
                                SEQUENCE LISTING

<110> Institute for Systems Biology
Zhang, Hui
      Aebersold, Rudolf H.

<120> TISSUE- AND SERUM-DERIVED GLYCOPROTEINS
  AND METHODS OF THEIR USE
  

<130> 460092.404PC

<140> PCT                  
<141> 2006-10-17  

<150> US 60/728,044       
<151> 2005-10-17  

<160> 14918

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1
Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile Asn
 1               5                  10                  15      
Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn
            20                  25      


<210> 2
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2
Lys Asn Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp
 1               5                  10                  15  


<210> 3
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3
Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu
 1               5                  10                  15      
Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu
            20                  25                  30          
Arg Thr
        


<210> 4
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4
Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly
 1               5                  10                  15      
Lys Leu
        


<210> 5
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5
Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala
 1               5                  10                  15      
Glu Val Asp Gly Thr Cys Tyr
            20              


<210> 6
<211> 18
<212> PRT
<213> Homo sapiens

<400> 6
Lys Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile
 1               5                  10                  15      
Lys Leu
        


<210> 7
<211> 23
<212> PRT
<213> Homo sapiens

<400> 7
Arg Gln Gln Gln His Leu Phe Gly Ser Asn Val Thr Asp Cys Ser Gly
 1               5                  10                  15      
Asn Phe Cys Leu Phe Arg Ser
            20              


<210> 8
<211> 23
<212> PRT
<213> Homo sapiens

<400> 8
Lys Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val Thr Phe
 1               5                  10                  15      
Thr Ile Pro Ala Asn Arg Glu
            20              


<210> 9
<211> 29
<212> PRT
<213> Homo sapiens

<400> 9
Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser
 1               5                  10                  15      
Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp
            20                  25                  


<210> 10
<211> 24
<212> PRT
<213> Homo sapiens

<400> 10
Lys Gly Cys Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser
 1               5                  10                  15      
Ala Ser Leu Glu Ser Val Arg Gly
            20                  


<210> 11
<211> 27
<212> PRT
<213> Homo sapiens

<400> 11
Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu Asn Asp Val
 1               5                  10                  15      
Leu His Cys Val Ala Phe Ala Val Pro Lys Ser
            20                  25          


<210> 12
<211> 9
<212> PRT
<213> Homo sapiens

<400> 12
Arg Glu Asn Gly Thr Ile Ser Arg Tyr
 1               5                  


<210> 13
<211> 37
<212> PRT
<213> Homo sapiens

<400> 13
Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp Glu His
 1               5                  10                  15      
Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly Thr Ser
            20                  25                  30          
Leu Thr Val Arg Val
        35          


<210> 14
<211> 11
<212> PRT
<213> Homo sapiens

<400> 14
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val
 1               5                  10      


<210> 15
<211> 34
<212> PRT
<213> Homo sapiens

<400> 15
Lys Ser Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu
 1               5                  10                  15      
Ser Gln Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly
            20                  25                  30          
Arg Lys
        


<210> 16
<211> 22
<212> PRT
<213> Homo sapiens

<400> 16
Lys Phe Asn Leu Thr Glu Thr Ser Glu Ala Glu Ile His Gln Ser Phe
 1               5                  10                  15      
Gln His Leu Leu Arg Thr
            20          


<210> 17
<211> 24
<212> PRT
<213> Homo sapiens

<400> 17
Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn Gly Ser Asn Phe
 1               5                  10                  15      
Gln Leu Glu Glu Ile Ser Arg Ala
            20                  


<210> 18
<211> 18
<212> PRT
<213> Homo sapiens

<400> 18
Lys Ser Val Gln Glu Ile Gln Ala Thr Phe Phe Tyr Phe Thr Pro Asn
 1               5                  10                  15      
Lys Thr
        


<210> 19
<211> 23
<212> PRT
<213> Homo sapiens

<400> 19
Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser Phe His Cys Tyr
 1               5                  10                  15      
Asp Gly Tyr Thr Leu Arg Gly
            20              


<210> 20
<211> 8
<212> PRT
<213> Homo sapiens

<400> 20
Arg Asn Glu Glu Tyr Asn Lys Ser
 1               5              


<210> 21
<211> 19
<212> PRT
<213> Homo sapiens

<400> 21
Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu
 1               5                  10                  15      
Asp Lys Gly
            


<210> 22
<211> 32
<212> PRT
<213> Homo sapiens

<400> 22
Arg Gln Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro
 1               5                  10                  15      
Val Ser Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala
            20                  25                  30          


<210> 23
<211> 14
<212> PRT
<213> Homo sapiens

<400> 23
Lys Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile
 1               5                  10                  


<210> 24
<211> 23
<212> PRT
<213> Homo sapiens

<400> 24
Lys Val Gly Gln Leu Gln Leu Ser His Asn Leu Ser Leu Val Ile Leu
 1               5                  10                  15      
Val Pro Gln Asn Leu Lys His
            20              


<210> 25
<211> 18
<212> PRT
<213> Homo sapiens

<400> 25
Arg Phe Ser Asp Gly Leu Glu Ser Asn Ser Ser Thr Gln Phe Glu Val
 1               5                  10                  15      
Lys Lys
        


<210> 26
<211> 21
<212> PRT
<213> Homo sapiens

<400> 26
Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp Ile Ser Glu Leu Val
 1               5                  10                  15      
Tyr Gly Ala Lys Leu
            20      


<210> 27
<211> 18
<212> PRT
<213> Homo sapiens

<400> 27
Lys Tyr Thr Gly Asn Ala Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp
 1               5                  10                  15      
Lys Met
        


<210> 28
<211> 22
<212> PRT
<213> Homo sapiens

<400> 28
Arg Thr Leu Asn Gln Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn
 1               5                  10                  15      
Ala Met Phe Val Lys Glu
            20          


<210> 29
<211> 18
<212> PRT
<213> Homo sapiens

<400> 29
Lys Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln
 1               5                  10                  15      
Arg Ala
        


<210> 30
<211> 11
<212> PRT
<213> Homo sapiens

<400> 30
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
 1               5                  10      


<210> 31
<211> 24
<212> PRT
<213> Homo sapiens

<400> 31
Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro Val
 1               5                  10                  15      
Asn Leu Thr Glu Pro Ala Lys Leu
            20                  


<210> 32
<211> 21
<212> PRT
<213> Homo sapiens

<400> 32
Arg Val Leu Ser Asn Asn Ser Asp Ala Asn Leu Glu Leu Ile Asn Thr
 1               5                  10                  15      
Trp Val Ala Lys Asn
            20      


<210> 33
<211> 14
<212> PRT
<213> Homo sapiens

<400> 33
Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys Glu
 1               5                  10                  


<210> 34
<211> 32
<212> PRT
<213> Homo sapiens

<400> 34
Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu Val Leu
 1               5                  10                  15      
Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly Ala Lys Lys
            20                  25                  30          


<210> 35
<211> 21
<212> PRT
<213> Homo sapiens

<400> 35
Lys Val Ser Asn Gln Thr Leu Ser Leu Phe Phe Thr Val Leu Gln Asp
 1               5                  10                  15      
Val Pro Val Arg Asp
            20      


<210> 36
<211> 17
<212> PRT
<213> Homo sapiens

<400> 36
Lys Ala Leu Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr
 1               5                  10                  15      
His
    


<210> 37
<211> 17
<212> PRT
<213> Homo sapiens

<400> 37
Lys Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg
 1               5                  10                  15      
Val
    


<210> 38
<211> 22
<212> PRT
<213> Homo sapiens

<400> 38
Lys Ala Phe Ile Thr Asn Phe Ser Met Asn Ile Asp Gly Met Thr Tyr
 1               5                  10                  15      
Pro Gly Ile Ile Lys Glu
            20          


<210> 39
<211> 27
<212> PRT
<213> Homo sapiens

<400> 39
Lys Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala
 1               5                  10                  15      
Glu Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr
            20                  25          


<210> 40
<211> 12
<212> PRT
<213> Homo sapiens

<400> 40
Thr Asn Ala Thr Leu Asp Gln Ile Thr Gly Lys Trp
 1               5                  10          


<210> 41
<211> 24
<212> PRT
<213> Homo sapiens

<400> 41
Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu
 1               5                  10                  15      
Phe Met Leu Asn Glu Val Lys Arg
            20                  


<210> 42
<211> 15
<212> PRT
<213> Homo sapiens

<400> 42
Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu Arg Trp
 1               5                  10                  15  


<210> 43
<211> 20
<212> PRT
<213> Homo sapiens

<400> 43
Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn
 1               5                  10                  15      
Ser Ser Arg Ser
            20  


<210> 44
<211> 25
<212> PRT
<213> Homo sapiens

<400> 44
Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu Ala Glu Ile His
 1               5                  10                  15      
Gln Ser Phe Gln His Leu Leu Arg Thr
            20                  25  


<210> 45
<211> 16
<212> PRT
<213> Homo sapiens

<400> 45
Lys Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr
 1               5                  10                  15      


<210> 46
<211> 35
<212> PRT
<213> Homo sapiens

<400> 46
Arg Glu Gly Asp His Glu Phe Leu Glu Val Pro Glu Ala Gln Glu Asp
 1               5                  10                  15      
Val Glu Ala Thr Phe Pro Val His Gln Pro Gly Asn Tyr Ser Cys Ser
            20                  25                  30          
Tyr Arg Thr
        35  


<210> 47
<211> 18
<212> PRT
<213> Homo sapiens

<400> 47
Lys Leu Gly Ala Cys Asn Asp Thr Leu Gln Gln Leu Met Glu Val Phe
 1               5                  10                  15      
Lys Phe
        


<210> 48
<211> 11
<212> PRT
<213> Homo sapiens

<400> 48
Arg Phe Gly Cys Glu Ile Glu Asn Asn Arg Ser
 1               5                  10      


<210> 49
<211> 31
<212> PRT
<213> Homo sapiens

<400> 49
Arg Asp Thr Ala Val Phe Glu Cys Leu Pro Gln His Ala Met Phe Gly
 1               5                  10                  15      
Asn Asp Thr Ile Thr Cys Thr Thr His Gly Asn Trp Thr Lys Leu
            20                  25                  30      


<210> 50
<211> 20
<212> PRT
<213> Homo sapiens

<400> 50
Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn Gly Ser His Val Leu
 1               5                  10                  15      
Gln Gly Arg Phe
            20  


<210> 51
<211> 16
<212> PRT
<213> Homo sapiens

<400> 51
Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val
 1               5                  10                  15      


<210> 52
<211> 10
<212> PRT
<213> Homo sapiens

<400> 52
Arg Asp Thr Phe Val Asn Ala Ser Arg Thr
 1               5                  10  


<210> 53
<211> 13
<212> PRT
<213> Homo sapiens

<400> 53
Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr
 1               5                  10              


<210> 54
<211> 15
<212> PRT
<213> Homo sapiens

<400> 54
Arg Val Tyr Lys Pro Ser Ala Gly Asn Asn Ser Leu Tyr Arg Asp
 1               5                  10                  15  


<210> 55
<211> 29
<212> PRT
<213> Homo sapiens

<400> 55
Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala
 1               5                  10                  15      
Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu
            20                  25                  


<210> 56
<211> 30
<212> PRT
<213> Homo sapiens

<400> 56
Arg Asn Pro Pro Met Gly Gly Asn Val Val Ile Phe Asp Thr Val Ile
 1               5                  10                  15      
Thr Asn Gln Glu Glu Pro Tyr Gln Asn His Ser Gly Arg Phe
            20                  25                  30  


<210> 57
<211> 25
<212> PRT
<213> Homo sapiens

<400> 57
Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro Ser Leu Thr
 1               5                  10                  15      
Ser Asp Leu Gln Ala Gln Ser Lys Gly
            20                  25  


<210> 58
<211> 15
<212> PRT
<213> Homo sapiens

<400> 58
Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr
 1               5                  10                  15  


<210> 59
<211> 15
<212> PRT
<213> Homo sapiens

<400> 59
Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn Lys Ser
 1               5                  10                  15  


<210> 60
<211> 13
<212> PRT
<213> Homo sapiens

<400> 60
Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg Asn
 1               5                  10              


<210> 61
<211> 19
<212> PRT
<213> Homo sapiens

<400> 61
Lys Leu His Ile Asn His Asn Asn Leu Thr Glu Ser Val Gly Pro Leu
 1               5                  10                  15      
Pro Lys Ser
            


<210> 62
<211> 23
<212> PRT
<213> Homo sapiens

<400> 62
Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln Asp Pro
 1               5                  10                  15      
Glu Ser Leu Gln Asp Arg Gly
            20              


<210> 63
<211> 35
<212> PRT
<213> Homo sapiens

<400> 63
Lys Ile Ile Thr Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly
 1               5                  10                  15      
Leu Tyr Thr Tyr Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile
            20                  25                  30          
Cys Arg Lys
        35  


<210> 64
<211> 22
<212> PRT
<213> Homo sapiens

<400> 64
Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe
 1               5                  10                  15      
Asn Trp Val Ser Arg Leu
            20          


<210> 65
<211> 34
<212> PRT
<213> Homo sapiens

<400> 65
Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser
 1               5                  10                  15      
Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu
            20                  25                  30          
Arg Phe
        


<210> 66
<211> 34
<212> PRT
<213> Homo sapiens

<400> 66
Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser
 1               5                  10                  15      
Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asp Ser Gly Glu
            20                  25                  30          
Arg Phe
        


<210> 67
<211> 25
<212> PRT
<213> Homo sapiens

<400> 67
Arg Val Glu Asn Thr Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu
 1               5                  10                  15      
Ser Asp Cys Ser Val Leu Ser Arg Lys
            20                  25  


<210> 68
<211> 24
<212> PRT
<213> Homo sapiens

<400> 68
Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser
 1               5                  10                  15      
Thr Val Ala Ser Val Tyr Lys Gly
            20                  


<210> 69
<211> 27
<212> PRT
<213> Homo sapiens

<400> 69
Lys Ile Cys Asp Leu Leu Val Ala Asn Asn His Phe Ala His Phe Phe
 1               5                  10                  15      
Ala Pro Gln Asn Leu Thr Asn Met Asn Lys Asn
            20                  25          


<210> 70
<211> 22
<212> PRT
<213> Homo sapiens

<400> 70
Lys Glu Asn Leu Thr Ala Pro Gly Ser Asp Ser Ala Val Phe Phe Glu
 1               5                  10                  15      
Gln Gly Thr Thr Arg Ile
            20          


<210> 71
<211> 23
<212> PRT
<213> Homo sapiens

<400> 71
Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe Asn Leu Thr Glu Leu Ser
 1               5                  10                  15      
Glu Ser Asp Val His Arg Gly
            20              


<210> 72
<211> 22
<212> PRT
<213> Homo sapiens

<400> 72
Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu Thr Asp Ser
 1               5                  10                  15      
Thr Val Leu Val Arg Trp
            20          


<210> 73
<211> 24
<212> PRT
<213> Homo sapiens

<400> 73
Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn
 1               5                  10                  15      
Gly Thr Met Leu Phe Phe Lys Gly
            20                  


<210> 74
<211> 16
<212> PRT
<213> Homo sapiens

<400> 74
Arg Ala Gln Leu Leu Gln Gly Leu Gly Phe Asn Leu Thr Glu Arg Ser
 1               5                  10                  15      


<210> 75
<211> 11
<212> PRT
<213> Homo sapiens

<400> 75
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val
 1               5                  10      


<210> 76
<211> 24
<212> PRT
<213> Homo sapiens

<400> 76
Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile Leu Asp His
 1               5                  10                  15      
Asn Leu Leu Glu Asn Ser Lys Ile
            20                  


<210> 77
<211> 15
<212> PRT
<213> Homo sapiens

<400> 77
Arg Cys Ile Gln Ala Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile
 1               5                  10                  15  


<210> 78
<211> 12
<212> PRT
<213> Homo sapiens

<400> 78
Leu Ala Asn Val Thr Leu Thr Cys Gln Ala Arg Leu
 1               5                  10          


<210> 79
<211> 17
<212> PRT
<213> Homo sapiens

<400> 79
Lys Tyr Asn Ser Gln Asn Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg
 1               5                  10                  15      
Ile
    


<210> 80
<211> 11
<212> PRT
<213> Homo sapiens

<400> 80
Lys Asn Asn Ser Asp Ile Ser Ser Thr Arg Gly
 1               5                  10      


<210> 81
<211> 24
<212> PRT
<213> Homo sapiens

<400> 81
Lys Val Thr Gln Asn Leu Thr Leu Ile Glu Glu Ser Leu Thr Ser Glu
 1               5                  10                  15      
Phe Ile His Asp Ile Asp Arg Glu
            20                  


<210> 82
<211> 23
<212> PRT
<213> Homo sapiens

<400> 82
Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly Glu Thr
 1               5                  10                  15      
Asp Pro Ser His Ser Lys Phe
            20              


<210> 83
<211> 23
<212> PRT
<213> Homo sapiens

<400> 83
Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu Ser Thr
 1               5                  10                  15      
Cys Glu Gln Leu Ala Lys Ala
            20              


<210> 84
<211> 21
<212> PRT
<213> Homo sapiens

<400> 84
Lys Leu Gly Ser Phe Glu Gly Leu Val Asn Leu Thr Phe Ile His Leu
 1               5                  10                  15      
Gln His Asn Arg Leu
            20      


<210> 85
<211> 23
<212> PRT
<213> Homo sapiens

<400> 85
Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp
 1               5                  10                  15      
Gln Asp Thr Ala Ile Arg Val
            20              


<210> 86
<211> 15
<212> PRT
<213> Homo sapiens

<400> 86
Lys Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp
 1               5                  10                  15  


<210> 87
<211> 23
<212> PRT
<213> Homo sapiens

<400> 87
Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser
 1               5                  10                  15      
Asp Thr Ala Gly Thr Cys Tyr
            20              


<210> 88
<211> 12
<212> PRT
<213> Homo sapiens

<400> 88
Lys His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser
 1               5                  10          


<210> 89
<211> 31
<212> PRT
<213> Homo sapiens

<400> 89
Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys Glu Thr Phe Gln Tyr
 1               5                  10                  15      
Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val Thr Glu Lys Glu
            20                  25                  30      


<210> 90
<211> 27
<212> PRT
<213> Homo sapiens

<400> 90
Arg Leu Glu Pro Val His Leu Gln Leu Gln Cys Met Ser Gln Glu Gln
 1               5                  10                  15      
Leu Ala Gln Val Ala Ala Asn Ala Thr Lys Glu
            20                  25          


<210> 91
<211> 11
<212> PRT
<213> Homo sapiens

<400> 91
Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys Ser
 1               5                  10      


<210> 92
<211> 21
<212> PRT
<213> Homo sapiens

<400> 92
Arg Val Ile Asp Phe Asn Cys Thr Thr Ser Ser Val Ser Ser Ala Leu
 1               5                  10                  15      
Ala Asn Thr Lys Asp
            20      


<210> 93
<211> 14
<212> PRT
<213> Homo sapiens

<400> 93
Arg Tyr Ala Glu Asp Lys Phe Asn Glu Thr Thr Glu Lys Ser
 1               5                  10                  


<210> 94
<211> 19
<212> PRT
<213> Homo sapiens

<400> 94
Arg Phe Glu Val Asp Ser Pro Val Tyr Asn Ala Thr Trp Ser Ala Ser
 1               5                  10                  15      
Leu Lys Asn
            


<210> 95
<211> 20
<212> PRT
<213> Homo sapiens

<400> 95
Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn Asp Thr
 1               5                  10                  15      
Phe His Lys Arg
            20  


<210> 96
<211> 11
<212> PRT
<213> Homo sapiens

<400> 96
Val Pro Ile Thr Asn Ala Thr Leu Asp Arg Ile
 1               5                  10      


<210> 97
<211> 12
<212> PRT
<213> Homo sapiens

<400> 97
Arg Asp Ile Glu Asn Phe Asn Ser Thr Gln Lys Phe
 1               5                  10          


<210> 98
<211> 14
<212> PRT
<213> Homo sapiens

<400> 98
Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe
 1               5                  10                  


<210> 99
<211> 15
<212> PRT
<213> Homo sapiens

<400> 99
Arg Ile Tyr Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp
 1               5                  10                  15  


<210> 100
<211> 10
<212> PRT
<213> Homo sapiens

<400> 100
Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu
 1               5                  10  


<210> 101
<211> 20
<212> PRT
<213> Homo sapiens

<400> 101
Arg Ala Val Asn Ile Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser
 1               5                  10                  15      
Leu Ile Arg Gly
            20  


<210> 102
<211> 15
<212> PRT
<213> Homo sapiens

<400> 102
Arg Ile Ser Glu Glu Asn Glu Thr Thr Cys Tyr Met Gly Lys Trp
 1               5                  10                  15  


<210> 103
<211> 36
<212> PRT
<213> Homo sapiens

<400> 103
Arg Trp Asp Pro Glu Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys
 1               5                  10                  15      
Pro Pro Pro Pro Gln Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu
            20                  25                  30          
Asn Tyr Arg Asp
        35      


<210> 104
<211> 23
<212> PRT
<213> Homo sapiens

<400> 104
Arg Gly Phe Gly Val Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro
 1               5                  10                  15      
Thr Glu Ala Ala Leu Arg Thr
            20              


<210> 105
<211> 27
<212> PRT
<213> Homo sapiens

<400> 105
Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn
 1               5                  10                  15      
Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp
            20                  25          


<210> 106
<211> 17
<212> PRT
<213> Homo sapiens

<400> 106
Lys Phe Val Glu Gly Ser His Asn Ser Thr Val Ser Leu Thr Thr Lys
 1               5                  10                  15      
Asn
    


<210> 107
<211> 20
<212> PRT
<213> Homo sapiens

<400> 107
Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly Glu Glu Leu Asn Val Thr
 1               5                  10                  15      
Phe Val Lys Gly
            20  


<210> 108
<211> 25
<212> PRT
<213> Homo sapiens

<400> 108
Arg Tyr Pro His Lys Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala
 1               5                  10                  15      
Asp Leu Gln Glu Asn Phe Cys Arg Asn
            20                  25  


<210> 109
<211> 11
<212> PRT
<213> Homo sapiens

<400> 109
Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val
 1               5                  10      


<210> 110
<211> 21
<212> PRT
<213> Homo sapiens

<400> 110
Lys Glu Gly Tyr Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly
 1               5                  10                  15      
Ile Ser Ser Arg Leu
            20      


<210> 111
<211> 13
<212> PRT
<213> Homo sapiens

<400> 111
Lys Leu Gly Asn Trp Ser Ala Met Pro Ser Cys Lys Ala
 1               5                  10              


<210> 112
<211> 14
<212> PRT
<213> Homo sapiens

<400> 112
Lys Phe Leu Asn Asp Thr Met Ala Val Tyr Glu Ala Lys Leu
 1               5                  10                  


<210> 113
<211> 29
<212> PRT
<213> Homo sapiens

<400> 113
Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser
 1               5                  10                  15      
Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu
            20                  25                  


<210> 114
<211> 19
<212> PRT
<213> Homo sapiens

<400> 114
Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr Glu Cys Leu His Val His
 1               5                  10                  15      
Cys Arg Gly
            


<210> 115
<211> 32
<212> PRT
<213> Homo sapiens

<400> 115
Arg Phe Ser Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn
 1               5                  10                  15      
Glu Thr Ile Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile
            20                  25                  30          


<210> 116
<211> 21
<212> PRT
<213> Homo sapiens

<400> 116
Lys Thr Leu Tyr Glu Thr Glu Val Phe Ser Thr Asp Phe Ser Asn Ile
 1               5                  10                  15      
Ser Ala Ala Lys Gln
            20      


<210> 117
<211> 17
<212> PRT
<213> Homo sapiens

<400> 117
Arg Phe Asn Ser Ser Tyr Leu Gln Gly Thr Asn Gln Ile Thr Gly Arg
 1               5                  10                  15      
Tyr
    


<210> 118
<211> 15
<212> PRT
<213> Homo sapiens

<400> 118
Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val Glu Arg Gly
 1               5                  10                  15  


<210> 119
<211> 11
<212> PRT
<213> Homo sapiens

<400> 119
Arg Glu Gln Gln Phe Asn Ser Thr Phe Arg Val
 1               5                  10      


<210> 120
<211> 21
<212> PRT
<213> Homo sapiens

<400> 120
Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His Gly Phe
 1               5                  10                  15      
Asn Phe Thr Arg Thr
            20      


<210> 121
<211> 17
<212> PRT
<213> Homo sapiens

<400> 121
Lys Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys
 1               5                  10                  15      
Thr
    


<210> 122
<211> 32
<212> PRT
<213> Homo sapiens

<400> 122
Lys Val Thr Ile Ser Gly Val Tyr Asp Leu Gly Asp Val Leu Glu Glu
 1               5                  10                  15      
Met Gly Ile Ala Asp Leu Phe Thr Asn Gln Ala Asn Phe Ser Arg Ile
            20                  25                  30          


<210> 123
<211> 25
<212> PRT
<213> Homo sapiens

<400> 123
Lys Thr Glu Leu Phe Ser Ser Ser Cys Pro Gly Gly Ile Met Leu Asn
 1               5                  10                  15      
Glu Thr Gly Gln Gly Tyr Gln Arg Phe
            20                  25  


<210> 124
<211> 17
<212> PRT
<213> Homo sapiens

<400> 124
Lys Val Thr Ala Cys His Ser Ser Gln Pro Asn Ala Thr Leu Tyr Lys
 1               5                  10                  15      
Met
    


<210> 125
<211> 27
<212> PRT
<213> Homo sapiens

<400> 125
Arg Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys
 1               5                  10                  15      
Pro Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala
            20                  25          


<210> 126
<211> 23
<212> PRT
<213> Homo sapiens

<400> 126
Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu
 1               5                  10                  15      
Phe Gln Asn Leu Ser Lys Leu
            20              


<210> 127
<211> 24
<212> PRT
<213> Homo sapiens

<400> 127
Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu
 1               5                  10                  15      
Glu Cys Lys Pro Cys Leu Lys Gln
            20                  


<210> 128
<211> 15
<212> PRT
<213> Homo sapiens

<400> 128
Lys Tyr Asp Phe Asn Ser Ser Met Leu Tyr Ser Thr Ala Lys Gly
 1               5                  10                  15  


<210> 129
<211> 19
<212> PRT
<213> Homo sapiens

<400> 129
Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val Leu Met Asn Gly Thr
 1               5                  10                  15      
Leu Lys Gln
            


<210> 130
<211> 16
<212> PRT
<213> Homo sapiens

<400> 130
Ser Pro Leu Asp Glu Glu Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly
 1               5                  10                  15      


<210> 131
<211> 22
<212> PRT
<213> Homo sapiens

<400> 131
Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp
 1               5                  10                  15      
Met Asn Gly Asp Arg Ile
            20          


<210> 132
<211> 23
<212> PRT
<213> Homo sapiens

<400> 132
Lys His Gly Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu Asn Gly
 1               5                  10                  15      
Ser Ser Val Glu Tyr Arg Cys
            20              


<210> 133
<211> 17
<212> PRT
<213> Homo sapiens

<400> 133
Lys Glu Tyr Glu Ser Tyr Ser Asp Phe Glu Arg Asn Val Thr Glu Lys
 1               5                  10                  15      
Met
    


<210> 134
<211> 32
<212> PRT
<213> Homo sapiens

<400> 134
Lys Ala Val Leu Gln Leu Asn Glu Glu Gly Val Asp Thr Ala Gly Ser
 1               5                  10                  15      
Thr Gly Val Thr Leu Asn Leu Thr Ser Lys Pro Ile Ile Leu Arg Phe
            20                  25                  30          


<210> 135
<211> 32
<212> PRT
<213> Homo sapiens

<400> 135
Arg Leu Ser His Asn Glu Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser
 1               5                  10                  15      
Phe Asn Val Ser Ser Leu Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu
            20                  25                  30          


<210> 136
<211> 12
<212> PRT
<213> Homo sapiens

<400> 136
Trp Ser Glu Ser Gly Gln Asn Val Thr Ala Arg Asn
 1               5                  10          


<210> 137
<211> 15
<212> PRT
<213> Homo sapiens

<400> 137
Lys Asn Leu Ser Met Pro Leu Leu Pro Ala Asp Phe His Lys Glu
 1               5                  10                  15  


<210> 138
<211> 10
<212> PRT
<213> Homo sapiens

<400> 138
Lys Asp Phe Val Asn Ala Ser Ser Lys Tyr
 1               5                  10  


<210> 139
<211> 12
<212> PRT
<213> Homo sapiens

<400> 139
Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile
 1               5                  10          


<210> 140
<211> 16
<212> PRT
<213> Homo sapiens

<400> 140
Arg Gly Gly Ser Ser Gly Trp Ser Gly Gly Leu Ala Gln Asn Arg Ser
 1               5                  10                  15      


<210> 141
<211> 21
<212> PRT
<213> Homo sapiens

<400> 141
Lys Leu Gln Ala Pro Leu Asn Tyr Thr Glu Phe Gln Lys Pro Ile Cys
 1               5                  10                  15      
Leu Pro Ser Lys Gly
            20      


<210> 142
<211> 22
<212> PRT
<213> Homo sapiens

<400> 142
Lys Glu His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn Gly Asn Tyr
 1               5                  10                  15      
Ser Thr Thr Gln Lys Thr
            20          


<210> 143
<211> 27
<212> PRT
<213> Homo sapiens

<400> 143
Arg Leu Gly His Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser
 1               5                  10                  15      
Ser Ser Gly Pro Val Asn Val Ser Asp Lys Ile
            20                  25          


<210> 144
<211> 13
<212> PRT
<213> Homo sapiens

<400> 144
Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly
 1               5                  10              


<210> 145
<211> 28
<212> PRT
<213> Homo sapiens

<400> 145
Arg Ala Asn Leu Ser Ser Gln Ala Leu Gln Met Ser Leu Asp Tyr Gly
 1               5                  10                  15      
Phe Val Thr Pro Leu Thr Ser Met Ser Ile Arg Gly
            20                  25              


<210> 146
<211> 22
<212> PRT
<213> Homo sapiens

<400> 146
Arg Met Ala Trp Pro Glu Asp His Val Phe Ile Ser Thr Pro Ser Phe
 1               5                  10                  15      
Asn Tyr Thr Gly Arg Asp
            20          


<210> 147
<211> 27
<212> PRT
<213> Homo sapiens

<400> 147
Lys Val Ser Glu His Ile Pro Val Tyr Gln Gln Glu Glu Asn Gln Thr
 1               5                  10                  15      
Asp Val Trp Thr Leu Leu Asn Gly Ser Lys Asp
            20                  25          


<210> 148
<211> 18
<212> PRT
<213> Homo sapiens

<400> 148
Arg Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser
 1               5                  10                  15      
Lys Lys
        


<210> 149
<211> 17
<212> PRT
<213> Homo sapiens

<400> 149
Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val Lys
 1               5                  10                  15      
Ala
    


<210> 150
<211> 32
<212> PRT
<213> Homo sapiens

<400> 150
Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu
 1               5                  10                  15      
Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu
            20                  25                  30          


<210> 151
<211> 10
<212> PRT
<213> Homo sapiens

<400> 151
Lys Asn Gly Ser Leu Phe Ala Phe Arg Gly
 1               5                  10  


<210> 152
<211> 26
<212> PRT
<213> Homo sapiens

<400> 152
Lys Glu His Glu Ala Gln Ser Asn Ala Ser Leu Asp Val Phe Leu Gly
 1               5                  10                  15      
His Thr Asn Val Glu Glu Leu Met Lys Leu
            20                  25      


<210> 153
<211> 16
<212> PRT
<213> Homo sapiens

<400> 153
Lys Asn Thr Thr Cys Gln Asp Leu Gln Ile Glu Val Thr Val Lys Gly
 1               5                  10                  15      


<210> 154
<211> 15
<212> PRT
<213> Homo sapiens

<400> 154
Arg Ala Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala
 1               5                  10                  15  


<210> 155
<211> 34
<212> PRT
<213> Homo sapiens

<400> 155
Lys Asn Cys Gly Val Asn Cys Ser Gly Asp Val Phe Thr Ala Leu Ile
 1               5                  10                  15      
Gly Glu Ile Ala Ser Pro Asn Tyr Pro Lys Pro Tyr Pro Glu Asn Ser
            20                  25                  30          
Arg Cys
        


<210> 156
<211> 12
<212> PRT
<213> Homo sapiens

<400> 156
Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg Glu
 1               5                  10          


<210> 157
<211> 25
<212> PRT
<213> Homo sapiens

<400> 157
Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp
 1               5                  10                  15      
Glu Tyr Ala Ile Phe Leu Thr Lys Lys
            20                  25  


<210> 158
<211> 23
<212> PRT
<213> Homo sapiens

<400> 158
Arg Ile Tyr Ser Asn His Ser Ala Leu Glu Ser Leu Ala Leu Ile Pro
 1               5                  10                  15      
Leu Gln Ala Pro Leu Lys Thr
            20              


<210> 159
<211> 20
<212> PRT
<213> Homo sapiens

<400> 159
Lys Val Asp Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser
 1               5                  10                  15      
Glu Ser Lys Arg
            20  


<210> 160
<211> 33
<212> PRT
<213> Homo sapiens

<400> 160
Arg Gln Asp Gly Glu Glu Val Leu Gln Cys Met Pro Val Cys Gly Arg
 1               5                  10                  15      
Pro Val Thr Pro Ile Ala Gln Asn Gln Thr Thr Leu Gly Ser Ser Arg
            20                  25                  30          
Ala
    


<210> 161
<211> 13
<212> PRT
<213> Homo sapiens

<400> 161
Leu Ala Leu Gly Ala Gln Asn His Thr Leu Gln Arg Leu
 1               5                  10              


<210> 162
<211> 21
<212> PRT
<213> Homo sapiens

<400> 162
Lys Gln Val Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His
 1               5                  10                  15      
Phe Thr Val Lys Thr
            20      


<210> 163
<211> 12
<212> PRT
<213> Homo sapiens

<400> 163
Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu
 1               5                  10          


<210> 164
<211> 18
<212> PRT
<213> Homo sapiens

<400> 164
Arg His Glu Glu Gly His Met Leu Asn Cys Thr Cys Phe Gly Gln Gly
 1               5                  10                  15      
Arg Gly
        


<210> 165
<211> 14
<212> PRT
<213> Homo sapiens

<400> 165
Lys Ile Asp Ser Thr Gly Asn Val Thr Asn Glu Leu Arg Val
 1               5                  10                  


<210> 166
<211> 20
<212> PRT
<213> Homo sapiens

<400> 166
Arg Phe Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr
 1               5                  10                  15      
Ser Ser Lys Lys
            20  


<210> 167
<211> 17
<212> PRT
<213> Homo sapiens

<400> 167
Phe Asn Leu Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys
 1               5                  10                  15      
Leu
    


<210> 168
<211> 23
<212> PRT
<213> Homo sapiens

<400> 168
Lys Met Leu Leu Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly
 1               5                  10                  15      
Thr Ile Met Phe Tyr Lys Gly
            20              


<210> 169
<211> 25
<212> PRT
<213> Homo sapiens

<400> 169
Arg Val Tyr Leu Gln Gly Leu Ile Asp Tyr Tyr Leu Phe Gly Asn Ser
 1               5                  10                  15      
Ser Thr Val Leu Glu Asp Ser Lys Ser
            20                  25  


<210> 170
<211> 23
<212> PRT
<213> Homo sapiens

<400> 170
Arg Val Val Gly Val Pro Tyr Gln Gly Asn Ala Thr Ala Leu Phe Ile
 1               5                  10                  15      
Leu Pro Ser Glu Gly Lys Met
            20              


<210> 171
<211> 13
<212> PRT
<213> Homo sapiens

<400> 171
Lys Asp Phe Tyr Val Asp Glu Asn Thr Thr Val Arg Val
 1               5                  10              


<210> 172
<211> 21
<212> PRT
<213> Homo sapiens

<400> 172
Arg Gly Thr Ala Gly Asn Ala Leu Met Asp Gly Ala Ser Gln Leu Met
 1               5                  10                  15      
Gly Glu Asn Arg Thr
            20      


<210> 173
<211> 16
<212> PRT
<213> Homo sapiens

<400> 173
Arg Asp Ser Val Ser Val Val Leu Gly Gln His Phe Phe Asn Arg Thr
 1               5                  10                  15      


<210> 174
<211> 16
<212> PRT
<213> Homo sapiens

<400> 174
Lys Ala Gly Leu Gln Ala Phe Phe Gln Val Gln Glu Cys Asn Lys Ser
 1               5                  10                  15      


<210> 175
<211> 14
<212> PRT
<213> Homo sapiens

<400> 175
Lys Glu Gly His Phe Tyr Tyr Asn Ile Ser Glu Val Lys Val
 1               5                  10                  


<210> 176
<211> 20
<212> PRT
<213> Homo sapiens

<400> 176
Lys Ile Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser
 1               5                  10                  15      
Tyr Val Lys His
            20  


<210> 177
<211> 10
<212> PRT
<213> Homo sapiens

<400> 177
Lys Thr Leu Phe Cys Asn Ala Ser Lys Glu
 1               5                  10  


<210> 178
<211> 23
<212> PRT
<213> Homo sapiens

<400> 178
Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly Glu Trp Pro Trp Gln
 1               5                  10                  15      
Val Ser Leu Gln Val Lys Leu
            20              


<210> 179
<211> 10
<212> PRT
<213> Homo sapiens

<400> 179
Lys Met Phe Ser Gln Asn Asp Thr Arg Cys
 1               5                  10  


<210> 180
<211> 20
<212> PRT
<213> Homo sapiens

<400> 180
Arg Tyr Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu
 1               5                  10                  15      
Val Asp Arg Tyr
            20  


<210> 181
<211> 19
<212> PRT
<213> Homo sapiens

<400> 181
Arg Asn Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr
 1               5                  10                  15      
Met Arg Cys
            


<210> 182
<211> 28
<212> PRT
<213> Homo sapiens

<400> 182
Arg Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro
 1               5                  10                  15      
Asn Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu
            20                  25              


<210> 183
<211> 11
<212> PRT
<213> Homo sapiens

<400> 183
Lys Trp Val Ser Asn Lys Thr Glu Gly Arg Ile
 1               5                  10      


<210> 184
<211> 21
<212> PRT
<213> Homo sapiens

<400> 184
Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly Leu Asn Leu Thr Ser
 1               5                  10                  15      
Thr Phe Leu Arg Lys
            20      


<210> 185
<211> 25
<212> PRT
<213> Homo sapiens

<400> 185
Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser
 1               5                  10                  15      
Trp Tyr Leu Asp Asp Asn Ile Lys Thr
            20                  25  


<210> 186
<211> 19
<212> PRT
<213> Homo sapiens

<400> 186
Arg Phe Gln Ser Pro Ala Gly Thr Glu Ala Leu Phe Glu Leu His Asn
 1               5                  10                  15      
Ile Ser Val
            


<210> 187
<211> 25
<212> PRT
<213> Homo sapiens

<400> 187
Asp Ser Ala Asn Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe
 1               5                  10                  15      
Gly Gly Ser Ala Pro Ser Glu Arg Leu
            20                  25  


<210> 188
<211> 13
<212> PRT
<213> Homo sapiens

<400> 188
Asn Ala Ala Tyr Val Asn Met Ser Asn His His Arg Gly
 1               5                  10              


<210> 189
<211> 15
<212> PRT
<213> Homo sapiens

<400> 189
Lys Asn Ala His Gly Glu Glu Lys Glu Asn Leu Thr Ala Arg Ala
 1               5                  10                  15  


<210> 190
<211> 16
<212> PRT
<213> Homo sapiens

<400> 190
Leu Asp Tyr Leu Asn Glu Thr Gln Gln Leu Thr Pro Glu Val Lys Ser
 1               5                  10                  15      


<210> 191
<211> 18
<212> PRT
<213> Homo sapiens

<400> 191
Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala Leu
 1               5                  10                  15      
Arg Asp
        


<210> 192
<211> 13
<212> PRT
<213> Homo sapiens

<400> 192
Arg Gly Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu
 1               5                  10              


<210> 193
<211> 18
<212> PRT
<213> Homo sapiens

<400> 193
Lys Phe Asn Pro Gly Ala Glu Ser Val Val Leu Ser Asn Ser Thr Leu
 1               5                  10                  15      
Lys Phe
        


<210> 194
<211> 10
<212> PRT
<213> Homo sapiens

<400> 194
Arg Gly Val Asn Phe Asn Val Ser Lys Val
 1               5                  10  


<210> 195
<211> 14
<212> PRT
<213> Homo sapiens

<400> 195
Lys Val Ser Asn Val Ser Cys Gln Ala Ser Val Ser Arg Met
 1               5                  10                  


<210> 196
<211> 12
<212> PRT
<213> Homo sapiens

<400> 196
Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val
 1               5                  10          


<210> 197
<211> 14
<212> PRT
<213> Homo sapiens

<400> 197
Lys Gly Leu Asn Leu Thr Glu Asp Thr Tyr Lys Pro Arg Ile
 1               5                  10                  


<210> 198
<211> 14
<212> PRT
<213> Homo sapiens

<400> 198
Arg Asp Asn Tyr Thr Asp Leu Val Ala Ile Gln Asn Lys Ala
 1               5                  10                  


<210> 199
<211> 33
<212> PRT
<213> Homo sapiens

<400> 199
Lys Asp Gln Tyr Val Glu Pro Glu Asn Val Thr Ile Gln Cys Asp Ser
 1               5                  10                  15      
Gly Tyr Gly Val Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn Arg
            20                  25                  30          
Thr
    


<210> 200
<211> 34
<212> PRT
<213> Homo sapiens

<400> 200
Lys Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr
 1               5                  10                  15      
Ser Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile
            20                  25                  30          
Arg Leu
        


<210> 201
<211> 13
<212> PRT
<213> Homo sapiens

<400> 201
Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly
 1               5                  10              


<210> 202
<211> 23
<212> PRT
<213> Homo sapiens

<400> 202
Lys Ala Gly Ala Phe Leu Gly Leu Thr Asn Val Ala Val Met Asn Leu
 1               5                  10                  15      
Ser Gly Asn Cys Leu Arg Asn
            20              


<210> 203
<211> 26
<212> PRT
<213> Homo sapiens

<400> 203
Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp Gly Glu Lys
 1               5                  10                  15      
Pro Asn Leu Ser Tyr Ile Ile Gly Lys Asp
            20                  25      


<210> 204
<211> 9
<212> PRT
<213> Homo sapiens

<400> 204
Lys Val Leu Asn Phe Thr Thr Lys Ala
 1               5                  


<210> 205
<211> 11
<212> PRT
<213> Homo sapiens

<400> 205
Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu
 1               5                  10      


<210> 206
<211> 16
<212> PRT
<213> Homo sapiens

<400> 206
Val Gly Asn Gly Thr Val Phe Phe Ile Leu Pro Asp Lys Gly Lys Met
 1               5                  10                  15      


<210> 207
<211> 21
<212> PRT
<213> Homo sapiens

<400> 207
Lys Val Val Asn Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val
 1               5                  10                  15      
Gln Ile Pro Lys Gly
            20      


<210> 208
<211> 21
<212> PRT
<213> Homo sapiens

<400> 208
Lys Phe Val Gln Gly Asn Ser Thr Glu Val Ala Cys His Pro Gly Tyr
 1               5                  10                  15      
Gly Leu Pro Lys Ala
            20      


<210> 209
<211> 33
<212> PRT
<213> Homo sapiens

<400> 209
Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu Ala Ser Val
 1               5                  10                  15      
Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp Asp Met Arg
            20                  25                  30          
Asp
    


<210> 210
<211> 22
<212> PRT
<213> Homo sapiens

<400> 210
Lys Leu Thr Asp Thr Ile Cys Gly Val Gly Asn Met Ser Ala Asn Ala
 1               5                  10                  15      
Ser Asp Gln Glu Arg Thr
            20          


<210> 211
<211> 33
<212> PRT
<213> Homo sapiens

<400> 211
Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His Gly Val Thr
 1               5                  10                  15      
Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr Ser Gly Arg
            20                  25                  30          
Asn
    


<210> 212
<211> 11
<212> PRT
<213> Homo sapiens

<400> 212
Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp
 1               5                  10      


<210> 213
<211> 25
<212> PRT
<213> Homo sapiens

<400> 213
Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe
 1               5                  10                  15      
Thr Ala Asn Asp Ser Gly Pro Arg Arg
            20                  25  


<210> 214
<211> 17
<212> PRT
<213> Homo sapiens

<400> 214
Arg Val Phe His Ile His Asn Glu Ser Trp Val Leu Leu Thr Pro Lys
 1               5                  10                  15      
Ala
    


<210> 215
<211> 23
<212> PRT
<213> Homo sapiens

<400> 215
Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Gly Pro Asp
 1               5                  10                  15      
Gln Asp Thr Ala Ile Arg Val
            20              


<210> 216
<211> 12
<212> PRT
<213> Homo sapiens

<400> 216
Arg Val Glu Leu Glu Asp Phe Asn Gly Asn Arg Thr
 1               5                  10          


<210> 217
<211> 22
<212> PRT
<213> Homo sapiens

<400> 217
Arg Ala Tyr Leu Leu Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu
 1               5                  10                  15      
Ser Glu Glu Asp Arg Ser
            20          


<210> 218
<211> 11
<212> PRT
<213> Homo sapiens

<400> 218
Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser
 1               5                  10      


<210> 219
<211> 25
<212> PRT
<213> Homo sapiens

<400> 219
Arg Phe Glu Gln Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp
 1               5                  10                  15      
Lys Asn Leu Thr Val Ser Val His Val
            20                  25  


<210> 220
<211> 15
<212> PRT
<213> Homo sapiens

<400> 220
Arg Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser
 1               5                  10                  15  


<210> 221
<211> 18
<212> PRT
<213> Homo sapiens

<400> 221
Arg Val Asn Gln Asn Leu Val Tyr Glu Ser Gly Ser Leu Asn Phe Ser
 1               5                  10                  15      
Lys Leu
        


<210> 222
<211> 18
<212> PRT
<213> Homo sapiens

<400> 222
Arg Asn Gln Ala Leu Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro
 1               5                  10                  15      
Leu Thr
        


<210> 223
<211> 24
<212> PRT
<213> Homo sapiens

<400> 223
Lys Gly Phe Leu Ala Leu Tyr Gln Thr Val Ala Val Asn Tyr Ser Gln
 1               5                  10                  15      
Pro Ile Ser Glu Ala Ser Arg Gly
            20                  


<210> 224
<211> 24
<212> PRT
<213> Homo sapiens

<400> 224
Lys Phe His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn
 1               5                  10                  15      
Ala Ser Val His Tyr Ile Arg Glu
            20                  


<210> 225
<211> 13
<212> PRT
<213> Homo sapiens

<400> 225
Asn Ile Gln Val Gln Glu Asn Phe Asn Ile Ser Arg Ile
 1               5                  10              


<210> 226
<211> 12
<212> PRT
<213> Homo sapiens

<400> 226
Arg Cys Phe Leu Gly Asn Gly Thr Gly Tyr Arg Gly
 1               5                  10          


<210> 227
<211> 16
<212> PRT
<213> Homo sapiens

<400> 227
Arg Thr Val Ile Arg Pro Phe Tyr Leu Thr Asn Ser Ser Gly Val Asp
 1               5                  10                  15      


<210> 228
<211> 21
<212> PRT
<213> Homo sapiens

<400> 228
Lys Leu Glu Thr Thr Val Asn Tyr Thr Asp Ser Gln Arg Pro Ile Cys
 1               5                  10                  15      
Leu Pro Ser Lys Gly
            20      


<210> 229
<211> 11
<212> PRT
<213> Homo sapiens

<400> 229
Arg Gly Ile Cys Asn Ser Ser Asp Val Arg Gly
 1               5                  10      


<210> 230
<211> 9
<212> PRT
<213> Homo sapiens

<400> 230
Arg Asn Tyr Thr Leu Thr Gly Arg Asp
 1               5                  


<210> 231
<211> 12
<212> PRT
<213> Homo sapiens

<400> 231
Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg
 1               5                  10          


<210> 232
<211> 22
<212> PRT
<213> Homo sapiens

<400> 232
Leu Val Ser Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp
 1               5                  10                  15      
Ser Thr Ser Glu Lys Ser
            20          


<210> 233
<211> 24
<212> PRT
<213> Homo sapiens

<400> 233
Arg Leu Ser Leu Leu Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile
 1               5                  10                  15      
Leu Asn Gln Leu Thr Ser Arg Asp
            20                  


<210> 234
<211> 17
<212> PRT
<213> Homo sapiens

<400> 234
Lys Gly Glu Leu Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys
 1               5                  10                  15      
Phe
    


<210> 235
<211> 12
<212> PRT
<213> Homo sapiens

<400> 235
Lys Cys Gly Asn Cys Ser Leu Thr Thr Leu Lys Asp
 1               5                  10          


<210> 236
<211> 14
<212> PRT
<213> Homo sapiens

<400> 236
Arg Leu Val Pro His Met Asn Val Ser Ala Val Glu Lys Gln
 1               5                  10                  


<210> 237
<211> 11
<212> PRT
<213> Homo sapiens

<400> 237
Lys Glu Leu Leu Glu Thr Val Val Asn Arg Thr
 1               5                  10      


<210> 238
<211> 20
<212> PRT
<213> Homo sapiens

<400> 238
His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro Glu
 1               5                  10                  15      
Leu Pro Lys Cys
            20  


<210> 239
<211> 19
<212> PRT
<213> Homo sapiens

<400> 239
Lys Tyr Asn Gln Asn Phe Ser Ala Gly Asn Asn Glu Asn Ile Met Glu
 1               5                  10                  15      
Ala His Val
            


<210> 240
<211> 19
<212> PRT
<213> Homo sapiens

<400> 240
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
 1               5                  10                  15      
Val Arg Ala
            


<210> 241
<211> 14
<212> PRT
<213> Homo sapiens

<400> 241
Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys Thr
 1               5                  10                  


<210> 242
<211> 24
<212> PRT
<213> Homo sapiens

<400> 242
Lys Ala Ala Thr Cys Ile Asn Pro Leu Asn Gly Ser Val Cys Glu Arg
 1               5                  10                  15      
Pro Ala Asn His Ser Ala Lys Gln
            20                  


<210> 243
<211> 9
<212> PRT
<213> Homo sapiens

<400> 243
Lys Asp Lys Asn Cys Thr Ser Arg Leu
 1               5                  


<210> 244
<211> 20
<212> PRT
<213> Homo sapiens

<400> 244
Lys Asn Gln Ser Val Asn Val Phe Leu Gly His Thr Ala Ile Asp Glu
 1               5                  10                  15      
Met Leu Lys Leu
            20  


<210> 245
<211> 22
<212> PRT
<213> Homo sapiens

<400> 245
Lys Phe Asn Thr Thr Tyr Ile Asn Ile Gly Ser Ser Tyr Phe Pro Glu
 1               5                  10                  15      
His Gly Tyr Phe Arg Ala
            20          


<210> 246
<211> 14
<212> PRT
<213> Homo sapiens

<400> 246
Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu
 1               5                  10                  


<210> 247
<211> 16
<212> PRT
<213> Homo sapiens

<400> 247
Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala
 1               5                  10                  15      


<210> 248
<211> 11
<212> PRT
<213> Homo sapiens

<400> 248
Lys His Asn Phe Ser His Cys Cys Ser Lys Val
 1               5                  10      


<210> 249
<211> 27
<212> PRT
<213> Homo sapiens

<400> 249
Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn Gly Gly Cys Thr
 1               5                  10                  15      
His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg
            20                  25          


<210> 250
<211> 26
<212> PRT
<213> Homo sapiens

<400> 250
Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val
 1               5                  10                  15      
Ile Ser Asn Gln Glu Cys Asn Ile Lys His
            20                  25      


<210> 251
<211> 10
<212> PRT
<213> Homo sapiens

<400> 251
Arg His Asn Ser Thr Gly Cys Leu Arg Met
 1               5                  10  


<210> 252
<211> 18
<212> PRT
<213> Homo sapiens

<400> 252
Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala
 1               5                  10                  15      
Lys Leu
        


<210> 253
<211> 20
<212> PRT
<213> Homo sapiens

<400> 253
Lys Asn Asn Phe Asn Gly Ser Leu Val Gln Ala Ser Tyr Gln His Glu
 1               5                  10                  15      
Glu Leu Arg Arg
            20  


<210> 254
<211> 24
<212> PRT
<213> Homo sapiens

<400> 254
Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro Gly Ala Pro
 1               5                  10                  15      
Pro Asn Val Ser Gly Arg Arg His
            20                  


<210> 255
<211> 28
<212> PRT
<213> Homo sapiens

<400> 255
Arg Trp Leu Asn Val Gln Leu Ser Pro Trp Gln Gly Ser Leu Gly Leu
 1               5                  10                  15      
Gln Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser
            20                  25              


<210> 256
<211> 21
<212> PRT
<213> Homo sapiens

<400> 256
Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser
 1               5                  10                  15      
Pro Asp Gly Lys Tyr
            20      


<210> 257
<211> 14
<212> PRT
<213> Homo sapiens

<400> 257
Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser
 1               5                  10                  


<210> 258
<211> 31
<212> PRT
<213> Homo sapiens

<400> 258
Arg Asn Cys Gln Asp Ile Asp Glu Cys Val Thr Gly Ile His Asn Cys
 1               5                  10                  15      
Ser Ile Asn Glu Thr Cys Phe Asn Ile Gln Gly Gly Phe Arg Cys
            20                  25                  30      


<210> 259
<211> 15
<212> PRT
<213> Homo sapiens

<400> 259
Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile
 1               5                  10                  15  


<210> 260
<211> 18
<212> PRT
<213> Homo sapiens

<400> 260
Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly Leu Gln
 1               5                  10                  15      
Arg Val
        


<210> 261
<211> 13
<212> PRT
<213> Homo sapiens

<400> 261
Lys Asn Val Thr Phe Trp Gly Arg Pro Leu Pro Arg Cys
 1               5                  10              


<210> 262
<211> 24
<212> PRT
<213> Homo sapiens

<400> 262
Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp Pro Asp Asp Val
 1               5                  10                  15      
Pro Pro Glu Gly Trp Asn Arg Thr
            20                  


<210> 263
<211> 16
<212> PRT
<213> Homo sapiens

<400> 263
Arg Trp Phe Ser Ala Gly Leu Ala Ser Asn Ser Ser Trp Leu Arg Glu
 1               5                  10                  15      


<210> 264
<211> 13
<212> PRT
<213> Homo sapiens

<400> 264
Lys Ala Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu
 1               5                  10              


<210> 265
<211> 9
<212> PRT
<213> Homo sapiens

<400> 265
Arg Glu Asn Gly Thr Val Ser Arg Tyr
 1               5                  


<210> 266
<211> 15
<212> PRT
<213> Homo sapiens

<400> 266
Arg Ser Ser Thr Ser Ser Ile Asp Ser Asn Ile Ser Ser Lys Ser
 1               5                  10                  15  


<210> 267
<211> 16
<212> PRT
<213> Homo sapiens

<400> 267
Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile
 1               5                  10                  15      


<210> 268
<211> 24
<212> PRT
<213> Homo sapiens

<400> 268
Arg Cys Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala
 1               5                  10                  15      
Gly Leu Glu Gln Val Pro Lys Gly
            20                  


<210> 269
<211> 37
<212> PRT
<213> Homo sapiens

<400> 269
Arg Phe Val Gln Ala Ile Cys Glu Gly Asp Asp Cys Gln Pro Pro Ala
 1               5                  10                  15      
Tyr Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro Pro Glu Val Val Gly
            20                  25                  30          
Leu Asp Leu Arg Asp
        35          


<210> 270
<211> 20
<212> PRT
<213> Homo sapiens

<400> 270
Arg Tyr Asn Trp Ser Phe Ile His Cys Pro Ala Cys Gln Cys Asn Gly
 1               5                  10                  15      
His Ser Lys Cys
            20  


<210> 271
<211> 11
<212> PRT
<213> Homo sapiens

<400> 271
Lys Trp Ser Asp Ile Trp Asn Ala Thr Lys Tyr
 1               5                  10      


<210> 272
<211> 16
<212> PRT
<213> Homo sapiens

<400> 272
Lys Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys Leu
 1               5                  10                  15      


<210> 273
<211> 22
<212> PRT
<213> Homo sapiens

<400> 273
Arg Ser His Glu Ile Trp Thr His Ser Cys Pro Gln Ser Pro Gly Asn
 1               5                  10                  15      
Gly Thr Asp Ala Ser His
            20          


<210> 274
<211> 28
<212> PRT
<213> Homo sapiens

<400> 274
Lys Met Pro Ser Gln Ala Pro Thr Gly Asn Phe Tyr Pro Gln Pro Leu
 1               5                  10                  15      
Leu Asn Ser Ser Met Cys Leu Glu Asp Ser Arg Tyr
            20                  25              


<210> 275
<211> 14
<212> PRT
<213> Homo sapiens

<400> 275
Arg Val Tyr Ser Gly Ile Leu Asn Gln Ser Glu Ile Lys Glu
 1               5                  10                  


<210> 276
<211> 25
<212> PRT
<213> Homo sapiens

<400> 276
Lys Val Ser Ala Ile Thr Leu Val Ser Ala Thr Ser Thr Thr Ala Asn
 1               5                  10                  15      
Met Thr Val Gly Pro Glu Gly Lys Trp
            20                  25  


<210> 277
<211> 16
<212> PRT
<213> Homo sapiens

<400> 277
Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly
 1               5                  10                  15      


<210> 278
<211> 35
<212> PRT
<213> Homo sapiens

<400> 278
Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala
 1               5                  10                  15      
Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser
            20                  25                  30          
Pro Arg Ala
        35  


<210> 279
<211> 18
<212> PRT
<213> Homo sapiens

<400> 279
Arg Ser Val Thr Leu Gln Ile Tyr Asn His Ser Leu Thr Leu Ser Ala
 1               5                  10                  15      
Arg Trp
        


<210> 280
<211> 28
<212> PRT
<213> Homo sapiens

<400> 280
Lys Gly His Phe Ile Tyr Lys Asn Val Ser Glu Asp Leu Pro Leu Pro
 1               5                  10                  15      
Thr Phe Ser Pro Thr Leu Leu Gly Asp Ser Arg Met
            20                  25              


<210> 281
<211> 24
<212> PRT
<213> Homo sapiens

<400> 281
Lys Gly Pro Ser Thr Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr
 1               5                  10                  15      
Glu Phe His Thr Thr Pro Lys Met
            20                  


<210> 282
<211> 15
<212> PRT
<213> Homo sapiens

<400> 282
Tyr Asn Asn His Asn Tyr Thr Asp Cys Thr Ser Glu Gly Arg Arg
 1               5                  10                  15  


<210> 283
<211> 12
<212> PRT
<213> Homo sapiens

<400> 283
Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys
 1               5                  10          


<210> 284
<211> 12
<212> PRT
<213> Homo sapiens

<400> 284
Lys Leu Asn Asp Thr Leu Asp Tyr Glu Cys His Asp
 1               5                  10          


<210> 285
<211> 13
<212> PRT
<213> Homo sapiens

<400> 285
Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg Ser
 1               5                  10              


<210> 286
<211> 16
<212> PRT
<213> Homo sapiens

<400> 286
Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys Gln Arg Trp
 1               5                  10                  15      


<210> 287
<211> 14
<212> PRT
<213> Homo sapiens

<400> 287
Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn
 1               5                  10                  


<210> 288
<211> 20
<212> PRT
<213> Homo sapiens

<400> 288
Arg Thr Asn Ile Asn Ser Ser Arg Asp Pro Asp Asn Ile Ala Ala Trp
 1               5                  10                  15      
Tyr Leu Arg Ser
            20  


<210> 289
<211> 28
<212> PRT
<213> Homo sapiens

<400> 289
Arg Gly Met Asn Leu Thr Val Phe Gly Gly Thr Val Thr Ala Phe Leu
 1               5                  10                  15      
Gly Ile Pro Tyr Ala Gln Pro Pro Leu Gly Arg Leu
            20                  25              


<210> 290
<211> 17
<212> PRT
<213> Homo sapiens

<400> 290
Lys Phe Val Gly Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg
 1               5                  10                  15      
Tyr
    


<210> 291
<211> 15
<212> PRT
<213> Homo sapiens

<400> 291
Asn Tyr Leu Asn Glu Thr Gln Gln Leu Thr Gln Glu Ile Lys Ala
 1               5                  10                  15  


<210> 292
<211> 28
<212> PRT
<213> Homo sapiens

<400> 292
Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr
 1               5                  10                  15      
Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu
            20                  25              


<210> 293
<211> 25
<212> PRT
<213> Homo sapiens

<400> 293
Arg Ser Asn Ser Thr Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp
 1               5                  10                  15      
Arg Met Ala Met Thr Leu Pro Arg Asn
            20                  25  


<210> 294
<211> 30
<212> PRT
<213> Homo sapiens

<400> 294
Arg Glu Val Asn Thr Ser Gly Phe Ala Pro Ala Arg Pro Pro Pro Gln
 1               5                  10                  15      
Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser Val Leu Arg Val
            20                  25                  30  


<210> 295
<211> 12
<212> PRT
<213> Homo sapiens

<400> 295
Lys Gly Ile Asn Tyr Asn Ser Ser Val Ala Lys Ser
 1               5                  10          


<210> 296
<211> 17
<212> PRT
<213> Homo sapiens

<400> 296
Lys Phe Gly Leu Tyr His Val Asp Phe Asn Asn Thr Asn Arg Pro Arg
 1               5                  10                  15      
Thr
    


<210> 297
<211> 14
<212> PRT
<213> Homo sapiens

<400> 297
Arg Gly Asp Val Leu His Asn Gly Asn Gly Thr Tyr Gln Ser
 1               5                  10                  


<210> 298
<211> 21
<212> PRT
<213> Homo sapiens

<400> 298
Lys Val Ala Ser Val Ile Asn Ile Asn Pro Asn Thr Thr His Ser Thr
 1               5                  10                  15      
Gly Ser Cys Arg Ser
            20      


<210> 299
<211> 23
<212> PRT
<213> Homo sapiens

<400> 299
Lys Ser His Ala Ala Ser Asp Ala Pro Glu Asn Leu Thr Leu Leu Ala
 1               5                  10                  15      
Glu Thr Ala Asp Ala Arg Gly
            20              


<210> 300
<211> 22
<212> PRT
<213> Homo sapiens

<400> 300
Lys Thr Asp Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val
 1               5                  10                  15      
Phe Leu Asn Met Arg Gly
            20          


<210> 301
<211> 19
<212> PRT
<213> Homo sapiens

<400> 301
Arg Cys Ala Thr Pro His Gly Asp Asn Ala Ser Leu Glu Ala Thr Phe
 1               5                  10                  15      
Val Lys Arg
            


<210> 302
<211> 14
<212> PRT
<213> Homo sapiens

<400> 302
Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg Cys
 1               5                  10                  


<210> 303
<211> 10
<212> PRT
<213> Homo sapiens

<400> 303
Arg Trp Glu Tyr Cys Asn Leu Thr Arg Cys
 1               5                  10  


<210> 304
<211> 22
<212> PRT
<213> Homo sapiens

<400> 304
Arg Ile Ser Ala Leu Gly Leu Pro Thr Asn Leu Thr His Ile Leu Leu
 1               5                  10                  15      
Phe Gly Met Gly Arg Gly
            20          


<210> 305
<211> 10
<212> PRT
<213> Homo sapiens

<400> 305
Lys Glu Thr Phe Phe Asn Leu Ser Lys Arg
 1               5                  10  


<210> 306
<211> 13
<212> PRT
<213> Homo sapiens

<400> 306
Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro Lys Asp
 1               5                  10              


<210> 307
<211> 15
<212> PRT
<213> Homo sapiens

<400> 307
Lys Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp
 1               5                  10                  15  


<210> 308
<211> 16
<212> PRT
<213> Homo sapiens

<400> 308
Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His Lys His
 1               5                  10                  15      


<210> 309
<211> 19
<212> PRT
<213> Homo sapiens

<400> 309
Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu Cys Ser Glu Asn
 1               5                  10                  15      
Trp Lys Gly
            


<210> 310
<211> 27
<212> PRT
<213> Homo sapiens

<400> 310
Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser Leu Pro Thr
 1               5                  10                  15      
Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile
            20                  25          


<210> 311
<211> 28
<212> PRT
<213> Homo sapiens

<400> 311
Lys Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr Ala Ala Leu Asn
 1               5                  10                  15      
Ser Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu
            20                  25              


<210> 312
<211> 20
<212> PRT
<213> Homo sapiens

<400> 312
Lys Tyr Gly Asn Pro Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp Pro
 1               5                  10                  15      
Val Phe Lys Ser
            20  


<210> 313
<211> 10
<212> PRT
<213> Homo sapiens

<400> 313
Arg Asn Val Thr Ala Glu Gln Ala Arg Asn
 1               5                  10  


<210> 314
<211> 15
<212> PRT
<213> Homo sapiens

<400> 314
Lys Leu Thr Gly Val Ala Gly Asn Tyr Thr Val Cys Gln Lys Asp
 1               5                  10                  15  


<210> 315
<211> 19
<212> PRT
<213> Homo sapiens

<400> 315
Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val
 1               5                  10                  15      
Cys Arg Glu
            


<210> 316
<211> 20
<212> PRT
<213> Homo sapiens

<400> 316
Arg Asn Glu Met Leu Glu Ile Gln Val Phe Asn Tyr Ser Lys Val Phe
 1               5                  10                  15      
Ser Asn Lys Leu
            20  


<210> 317
<211> 15
<212> PRT
<213> Homo sapiens

<400> 317
Lys Ala Ala Ile Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser
 1               5                  10                  15  


<210> 318
<211> 12
<212> PRT
<213> Homo sapiens

<400> 318
Arg Leu His Glu Ile Thr Asn Glu Thr Phe Arg Gly
 1               5                  10          


<210> 319
<211> 22
<212> PRT
<213> Homo sapiens

<400> 319
Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala Gln Gly
 1               5                  10                  15      
Val Trp Met Asn Lys Val
            20          


<210> 320
<211> 14
<212> PRT
<213> Homo sapiens

<400> 320
Lys Ile Gly Gly Ile Trp Thr Trp Val Gly Thr Asn Lys Ser
 1               5                  10                  


<210> 321
<211> 14
<212> PRT
<213> Homo sapiens

<400> 321
Met Met Leu Gln Asn Ile Leu Gln Ile Asn Arg Ser Lys Arg
 1               5                  10                  


<210> 322
<211> 19
<212> PRT
<213> Homo sapiens

<400> 322
Arg Val Val Leu Leu Asp Pro Lys Pro Val Ala Asn Val Thr Cys Val
 1               5                  10                  15      
Asn Lys His
            


<210> 323
<211> 18
<212> PRT
<213> Homo sapiens

<400> 323
Lys Thr Ile His Asp Leu His Leu Phe Ile Glu Asn Ile Asp Phe Asn
 1               5                  10                  15      
Lys Ser
        


<210> 324
<211> 14
<212> PRT
<213> Homo sapiens

<400> 324
Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala
 1               5                  10                  


<210> 325
<211> 13
<212> PRT
<213> Homo sapiens

<400> 325
Val Phe Gly Glu Leu Cys Gly Val Asn Glu Asn Arg Thr
 1               5                  10              


<210> 326
<211> 14
<212> PRT
<213> Homo sapiens

<400> 326
Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val
 1               5                  10                  


<210> 327
<211> 29
<212> PRT
<213> Homo sapiens

<400> 327
Arg Thr Glu Pro Met Gln Val Ala Leu His Cys Thr Asn Gly Ser Val
 1               5                  10                  15      
Val Tyr His Glu Val Leu Asn Ala Met Glu Cys Lys Cys
            20                  25                  


<210> 328
<211> 18
<212> PRT
<213> Homo sapiens

<400> 328
Arg Gly Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile
 1               5                  10                  15      
Lys Ser
        


<210> 329
<211> 10
<212> PRT
<213> Homo sapiens

<400> 329
Arg Met Asn Lys Thr Val Ala Val Arg Thr
 1               5                  10  


<210> 330
<211> 31
<212> PRT
<213> Homo sapiens

<400> 330
Lys His Gly Ser Asn Asn Val Gly Leu Ser Glu Asn Leu Thr Asp Gly
 1               5                  10                  15      
Ala Ala Ala Gly Asn Gly Asp Gly Gly Leu Val Pro Gln Arg Lys
            20                  25                  30      


<210> 331
<211> 18
<212> PRT
<213> Homo sapiens

<400> 331
Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Asn Thr Ser Leu Glu Thr
 1               5                  10                  15      
Arg Leu
        


<210> 332
<211> 16
<212> PRT
<213> Homo sapiens

<400> 332
Arg Lys Val His Leu Met Gly Tyr Asn Cys Asn Ala Thr Thr Lys Cys
 1               5                  10                  15      


<210> 333
<211> 36
<212> PRT
<213> Homo sapiens

<400> 333
Lys Val Leu Pro Ser Leu Gly Ile Ser Asn Val Phe Thr Ser His Ala
 1               5                  10                  15      
Asp Leu Ser Gly Ile Ser Asn His Ser Asn Ile Gln Val Ser Glu Met
            20                  25                  30          
Val His Lys Ala
        35      


<210> 334
<211> 13
<212> PRT
<213> Homo sapiens

<400> 334
Gly Gly Asn Thr Ser Thr Asp His Phe Ser Leu Arg Ala
 1               5                  10              


<210> 335
<211> 16
<212> PRT
<213> Homo sapiens

<400> 335
Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val
 1               5                  10                  15      


<210> 336
<211> 23
<212> PRT
<213> Homo sapiens

<400> 336
Arg Val Ala Val Val Gln His Ala Pro Ser Glu Ser Val Asp Asn Ala
 1               5                  10                  15      
Ser Met Pro Pro Val Lys Val
            20              


<210> 337
<211> 29
<212> PRT
<213> Homo sapiens

<400> 337
Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn
 1               5                  10                  15      
Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val
            20                  25                  


<210> 338
<211> 36
<212> PRT
<213> Homo sapiens

<400> 338
Lys Thr Thr Thr Val Gln Val Pro Met Met His Gln Met Glu Gln Tyr
 1               5                  10                  15      
Tyr His Leu Val Asp Met Glu Leu Asn Cys Thr Val Leu Gln Met Asp
            20                  25                  30          
Tyr Ser Lys Asn
        35      


<210> 339
<211> 16
<212> PRT
<213> Homo sapiens

<400> 339
Arg Ser Thr Ile Ile Ser Asn Thr Thr Asn Pro Ile Trp His Arg Glu
 1               5                  10                  15      


<210> 340
<211> 14
<212> PRT
<213> Homo sapiens

<400> 340
Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln Leu
 1               5                  10                  


<210> 341
<211> 27
<212> PRT
<213> Homo sapiens

<400> 341
Arg Ile Ala Ile His Ala Leu Ala Thr Asn Met Gly Ala Gly Thr Glu
 1               5                  10                  15      
Gly Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp
            20                  25          


<210> 342
<211> 18
<212> PRT
<213> Homo sapiens

<400> 342
Lys Leu Pro Tyr Gln Gly Asn Ala Thr Met Leu Val Val Leu Met Glu
 1               5                  10                  15      
Lys Met
        


<210> 343
<211> 15
<212> PRT
<213> Homo sapiens

<400> 343
Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys Glu
 1               5                  10                  15  


<210> 344
<211> 8
<212> PRT
<213> Homo sapiens

<400> 344
Lys Val Val Asn Pro Thr Gln Lys
 1               5              


<210> 345
<211> 15
<212> PRT
<213> Homo sapiens

<400> 345
Lys Val Val Asn Ser Thr Thr Gly Pro Gly Glu His Leu Arg Asn
 1               5                  10                  15  


<210> 346
<211> 20
<212> PRT
<213> Homo sapiens

<400> 346
Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn Ser Thr
 1               5                  10                  15      
Ala Asp Arg Glu
            20  


<210> 347
<211> 26
<212> PRT
<213> Homo sapiens

<400> 347
Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu Phe Ser Leu Gly Met Gly
 1               5                  10                  15      
Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg
            20                  25      


<210> 348
<211> 23
<212> PRT
<213> Homo sapiens

<400> 348
Lys Thr Ala Phe Ile Thr Asn Phe Thr Leu Thr Ile Asp Gly Val Thr
 1               5                  10                  15      
Tyr Pro Gly Asn Val Lys Glu
            20              


<210> 349
<211> 20
<212> PRT
<213> Homo sapiens

<400> 349
Lys Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser
 1               5                  10                  15      
Glu Pro Arg Ala
            20  


<210> 350
<211> 24
<212> PRT
<213> Homo sapiens

<400> 350
Arg Ser Asn Lys Thr Leu Ala Asp Ser Leu Asp Asn Ala Asn Asp Pro
 1               5                  10                  15      
His Asp Pro Ile Val Asn Arg Leu
            20                  


<210> 351
<211> 26
<212> PRT
<213> Homo sapiens

<400> 351
Lys Val Ser Pro Arg Gly Ile Ile Leu Thr Asp Asn Leu Thr Asn Gln
 1               5                  10                  15      
Leu Ile Glu Asn Val Ser Ile Tyr Arg Ile
            20                  25      


<210> 352
<211> 36
<212> PRT
<213> Homo sapiens

<400> 352
Arg Phe Asn Phe Gln Gly Thr Cys Glu Tyr Leu Leu Ser Ala Pro Cys
 1               5                  10                  15      
His Gly Pro Pro Leu Gly Ala Glu Asn Phe Thr Val Thr Val Ala Asn
            20                  25                  30          
Glu His Arg Gly
        35      


<210> 353
<211> 22
<212> PRT
<213> Homo sapiens

<400> 353
Lys Thr Phe Ser Ser Met Thr Cys Ala Ser Gly Ala Asn Val Ser Glu
 1               5                  10                  15      
Gln Leu Ser Leu Lys Leu
            20          


<210> 354
<211> 32
<212> PRT
<213> Homo sapiens

<400> 354
Arg Asp Tyr Lys Gln Thr Gly Asp Asn Leu Ser Ser Met Leu Leu Glu
 1               5                  10                  15      
Asn Leu Thr Asp Asn Glu Ser Glu Asn Thr Asn Leu Lys Lys Lys Val
            20                  25                  30          


<210> 355
<211> 35
<212> PRT
<213> Homo sapiens

<400> 355
Lys Ile Gln Ser Pro Leu Phe Thr Leu Asp Ala Asn Ala Asp Ile Gly
 1               5                  10                  15      
Asn Gly Thr Thr Ser Ala Asn Glu Ala Gly Ile Ala Ala Ser Ile Thr
            20                  25                  30          
Ala Lys Gly
        35  


<210> 356
<211> 27
<212> PRT
<213> Homo sapiens

<400> 356
Lys His Tyr Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro Val
 1               5                  10                  15      
Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu
            20                  25          


<210> 357
<211> 26
<212> PRT
<213> Homo sapiens

<400> 357
Ala Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro
 1               5                  10                  15      
Gly Asp Lys Val Asn Ile Ser Cys Lys Ala
            20                  25      


<210> 358
<211> 17
<212> PRT
<213> Homo sapiens

<400> 358
Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala Lys
 1               5                  10                  15      
Ala
    


<210> 359
<211> 35
<212> PRT
<213> Homo sapiens

<400> 359
Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys Thr Ser Gly Ala Tyr Ser
 1               5                  10                  15      
Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr Tyr Pro Leu Thr Gly Asp
            20                  25                  30          
Thr Arg Leu
        35  


<210> 360
<211> 16
<212> PRT
<213> Homo sapiens

<400> 360
Lys Asn Tyr His Gln Pro Ala Ile Leu Asn Ser Ser Ala Leu Arg Gln
 1               5                  10                  15      


<210> 361
<211> 18
<212> PRT
<213> Homo sapiens

<400> 361
Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser Val Thr Ala Thr
 1               5                  10                  15      
Arg Ser
        


<210> 362
<211> 23
<212> PRT
<213> Homo sapiens

<400> 362
Arg Ser Ile Leu Glu Leu Ser Pro Gln Pro Lys Asn Phe Asn Arg Thr
 1               5                  10                  15      
Ala Thr Gly Trp Arg Leu Gln
            20              


<210> 363
<211> 15
<212> PRT
<213> Homo sapiens

<400> 363
Lys Met Ala Ala Asn Ser Ser Gly Gln Gly Phe Gln Asn Lys Asn
 1               5                  10                  15  


<210> 364
<211> 10
<212> PRT
<213> Homo sapiens

<400> 364
Lys Leu Cys Asp Asn Leu Ser Thr Lys Asn
 1               5                  10  


<210> 365
<211> 14
<212> PRT
<213> Homo sapiens

<400> 365
Lys Ile Asp Val Asn Ser Trp Ile Glu Asn Phe Thr Lys Thr
 1               5                  10                  


<210> 366
<211> 13
<212> PRT
<213> Homo sapiens

<400> 366
Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser
 1               5                  10              


<210> 367
<211> 17
<212> PRT
<213> Homo sapiens

<400> 367
Arg Asp Asn Ala Asn Asn Ser Pro Tyr Leu Gln Met Asn Ser Leu Arg
 1               5                  10                  15      
Ala
    


<210> 368
<211> 26
<212> PRT
<213> Homo sapiens

<400> 368
Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu Leu Pro
 1               5                  10                  15      
Trp Thr Gln His Ser Pro His Thr Arg Leu
            20                  25      


<210> 369
<211> 27
<212> PRT
<213> Homo sapiens

<400> 369
Lys Gln Pro Thr Pro Ile Ala Asn Thr Ser Ser Gln Gln Ala Val Phe
 1               5                  10                  15      
Thr Ser Ala Arg Gln Leu Pro Ser Ala Arg Thr
            20                  25          


<210> 370
<211> 10
<212> PRT
<213> Homo sapiens

<400> 370
Lys Asp Asn Asn Ser Ile Ile Thr Arg Lys
 1               5                  10  


<210> 371
<211> 26
<212> PRT
<213> Homo sapiens

<400> 371
Arg Phe Met Gly Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly
 1               5                  10                  15      
Leu Gly Ser Leu Gly Asp Val Ser Lys Asn
            20                  25      


<210> 372
<211> 10
<212> PRT
<213> Homo sapiens

<400> 372
Arg Lys Met Ser Asn Ile Thr Phe Leu Asn
 1               5                  10  


<210> 373
<211> 31
<212> PRT
<213> Homo sapiens

<400> 373
Lys Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu
 1               5                  10                  15      
Phe His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu Val Lys Gly
            20                  25                  30      


<210> 374
<211> 18
<212> PRT
<213> Homo sapiens

<400> 374
Lys Asn Leu Thr Asp Phe Ala Glu Gln Tyr Ser Ile Gln Asp Trp Ala
 1               5                  10                  15      
Lys Arg
        


<210> 375
<211> 39
<212> PRT
<213> Homo sapiens

<400> 375
Arg Gln Pro Gln Pro Val His Leu Leu Pro Leu His Gly Ile Gln His
 1               5                  10                  15      
Leu Asn Met Val Phe Ser Asn Leu Thr Leu Glu His Ile Asn Ala Ile
            20                  25                  30          
Leu Leu Gly Ala Tyr Arg Gln
        35                  


<210> 376
<211> 29
<212> PRT
<213> Homo sapiens

<400> 376
Arg Gly Gly Leu Asn Leu Thr Ala Val Thr Val Ala Ala Glu Asn Asn
 1               5                  10                  15      
His Thr Val Ala Phe Leu Gly Thr Ser Asp Gly Arg Ile
            20                  25                  


<210> 377
<211> 20
<212> PRT
<213> Homo sapiens

<400> 377
Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln
 1               5                  10                  15      
Thr Leu Arg Glu
            20  


<210> 378
<211> 15
<212> PRT
<213> Homo sapiens

<400> 378
Lys Gly Thr Asn Ser Ser Ala Ser Ser Asn Phe Arg Cys Arg Ser
 1               5                  10                  15  


<210> 379
<211> 30
<212> PRT
<213> Homo sapiens

<400> 379
Arg Asn Leu Ser Ser Leu Glu Ser Val Gln Leu Asp His Asn Gln Leu
 1               5                  10                  15      
Glu Thr Leu Pro Gly Asp Val Phe Gly Ala Leu Pro Arg Leu
            20                  25                  30  


<210> 380
<211> 12
<212> PRT
<213> Homo sapiens

<400> 380
Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser
 1               5                  10          


<210> 381
<211> 16
<212> PRT
<213> Homo sapiens

<400> 381
Lys Ala Leu Tyr Ser Phe Ala Pro Ile Ser Met His Cys Asn Lys Ser
 1               5                  10                  15      


<210> 382
<211> 18
<212> PRT
<213> Homo sapiens

<400> 382
Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr Ile His
 1               5                  10                  15      
Arg Ala
        


<210> 383
<211> 12
<212> PRT
<213> Homo sapiens

<400> 383
Arg Phe Gly Tyr Ile Leu His Thr Asp Asn Arg Thr
 1               5                  10          


<210> 384
<211> 17
<212> PRT
<213> Homo sapiens

<400> 384
Arg Glu Asp Gln Tyr His Tyr Leu Leu Asp Arg Asn Leu Ser Cys Arg
 1               5                  10                  15      
Val
    


<210> 385
<211> 19
<212> PRT
<213> Homo sapiens

<400> 385
Lys Leu Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala Val
 1               5                  10                  15      
Cys Arg Glu
            


<210> 386
<211> 12
<212> PRT
<213> Homo sapiens

<400> 386
Lys Glu Val Phe Val His Pro Asn Tyr Ser Lys Ser
 1               5                  10          


<210> 387
<211> 21
<212> PRT
<213> Homo sapiens

<400> 387
Arg Ile Gln Met Leu Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser
 1               5                  10                  15      
Ser Met Ala Arg Gly
            20      


<210> 388
<211> 21
<212> PRT
<213> Homo sapiens

<400> 388
Lys Glu Pro Gly Ser Asn Val Thr Met Ser Val Asp Ala Glu Cys Val
 1               5                  10                  15      
Pro Met Val Arg Asp
            20      


<210> 389
<211> 23
<212> PRT
<213> Homo sapiens

<400> 389
Lys Val Ser Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp
 1               5                  10                  15      
Gly Glu Cys Cys Pro Arg Cys
            20              


<210> 390
<211> 17
<212> PRT
<213> Homo sapiens

<400> 390
Arg Met Glu Ala Cys Met Leu Asn Gly Thr Val Ile Gly Pro Gly Lys
 1               5                  10                  15      
Thr
    


<210> 391
<211> 18
<212> PRT
<213> Homo sapiens

<400> 391
Lys Gly Gln Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys
 1               5                  10                  15      
Arg Ser
        


<210> 392
<211> 12
<212> PRT
<213> Homo sapiens

<400> 392
Val Cys Leu Pro Asp Asn Glu Thr Leu Tyr Arg Ser
 1               5                  10          


<210> 393
<211> 17
<212> PRT
<213> Homo sapiens

<400> 393
Arg Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg
 1               5                  10                  15      
Ile
    


<210> 394
<211> 28
<212> PRT
<213> Homo sapiens

<400> 394
Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val
 1               5                  10                  15      
Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu
            20                  25              


<210> 395
<211> 10
<212> PRT
<213> Homo sapiens

<400> 395
Lys Trp Gln Met Asn Phe Thr Val Arg Tyr
 1               5                  10  


<210> 396
<211> 23
<212> PRT
<213> Homo sapiens

<400> 396
Lys Met Ser Gly Gly Ser Thr Met Ser Ser Gly Gly Gly Asn Thr Asn
 1               5                  10                  15      
Asn Ser Asn Ser Lys Lys Lys
            20              


<210> 397
<211> 21
<212> PRT
<213> Homo sapiens

<400> 397
Lys Thr Val Val Thr Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn
 1               5                  10                  15      
Val Asp Ser Arg Tyr
            20      


<210> 398
<211> 17
<212> PRT
<213> Homo sapiens

<400> 398
Arg Gln Ala Glu Glu Ala Glu Glu Gln Ser Asn Val Asn Leu Ser Lys
 1               5                  10                  15      
Phe
    


<210> 399
<211> 15
<212> PRT
<213> Homo sapiens

<400> 399
Lys Ala Phe Ser Gln Asn Ile Ser Leu Val Gln His Leu Arg Thr
 1               5                  10                  15  


<210> 400
<211> 23
<212> PRT
<213> Homo sapiens

<400> 400
Arg Pro Val Asp Lys Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr
 1               5                  10                  15      
Asn Ala Leu Gly Ala Arg Gln
            20              


<210> 401
<211> 30
<212> PRT
<213> Homo sapiens

<400> 401
Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp Thr
 1               5                  10                  15      
Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu
            20                  25                  30  


<210> 402
<211> 19
<212> PRT
<213> Homo sapiens

<400> 402
Arg Gln Gly Ser Leu Gly Leu Gln Tyr Asn Ala Ser Gln Glu Trp Asp
 1               5                  10                  15      
Leu Arg Arg
            


<210> 403
<211> 15
<212> PRT
<213> Homo sapiens

<400> 403
Lys Ser Leu Asn Val Ser Ser Ser Val Asn Gln Ala Ser Arg Leu
 1               5                  10                  15  


<210> 404
<211> 11
<212> PRT
<213> Homo sapiens

<400> 404
Lys Asn Ser Ser Asn Trp Lys Leu Phe Lys Glu
 1               5                  10      


<210> 405
<211> 23
<212> PRT
<213> Homo sapiens

<400> 405
Lys Asn Pro Thr Asp Glu Tyr Leu Asp Ala Met Met Asn Glu Ala Pro
 1               5                  10                  15      
Gly Pro Ile Asn Phe Thr Met
            20              


<210> 406
<211> 19
<212> PRT
<213> Homo sapiens

<400> 406
Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His Gln
 1               5                  10                  15      
Leu Arg Gln
            


<210> 407
<211> 22
<212> PRT
<213> Homo sapiens

<400> 407
Arg Ser Thr Glu Arg Asn Val Ser Val Glu Ala Leu Ala Ser Ala Leu
 1               5                  10                  15      
Gln Leu Leu Ala Arg Glu
            20          


<210> 408
<211> 28
<212> PRT
<213> Homo sapiens

<400> 408
Arg Glu His Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met
 1               5                  10                  15      
Cys Gly His Tyr Thr Gln Val Val Trp Ala Lys Thr
            20                  25              


<210> 409
<211> 20
<212> PRT
<213> Homo sapiens

<400> 409
Lys Ser Leu Pro Asn Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala Thr
 1               5                  10                  15      
Gly Gly Arg Ala
            20  


<210> 410
<211> 33
<212> PRT
<213> Homo sapiens

<400> 410
Ala Met Val Asn Thr Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr
 1               5                  10                  15      
Glu Gly Pro Val Ala Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys
            20                  25                  30          
Glu
    


<210> 411
<211> 21
<212> PRT
<213> Homo sapiens

<400> 411
Lys Glu Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser
 1               5                  10                  15      
Glu Asp Phe Lys Cys
            20      


<210> 412
<211> 21
<212> PRT
<213> Homo sapiens

<400> 412
Arg Asn His Pro Asn Ile Thr Phe Phe Val Tyr Val Ser Asn Phe Thr
 1               5                  10                  15      
Trp Pro Ile Lys Ile
            20      


<210> 413
<211> 32
<212> PRT
<213> Homo sapiens

<400> 413
Arg Tyr Leu His Thr Ala Val Ile Val Ser Gly Thr Met Leu Val Phe
 1               5                  10                  15      
Gly Gly Asn Thr His Asn Asp Thr Ser Met Ser His Gly Ala Lys Cys
            20                  25                  30          


<210> 414
<211> 32
<212> PRT
<213> Homo sapiens

<400> 414
Arg Asp Val Leu Gln Asn His Leu Thr Glu Val Leu Thr Leu Val Ala
 1               5                  10                  15      
Met Glu Leu Pro His Asn Val Ser Ser Ala Glu Ala Val Leu Arg His
            20                  25                  30          


<210> 415
<211> 28
<212> PRT
<213> Homo sapiens

<400> 415
Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu Pro Pro Ile
 1               5                  10                  15      
Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu
            20                  25              


<210> 416
<211> 22
<212> PRT
<213> Homo sapiens

<400> 416
Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu Asn Leu Thr Asn Ala
 1               5                  10                  15      
Val Ala Thr Ala Arg Gln
            20          


<210> 417
<211> 17
<212> PRT
<213> Homo sapiens

<400> 417
Arg Glu Asn Gln Ser Ile Leu Ile Thr Gly Glu Ser Gly Ala Gly Lys
 1               5                  10                  15      
Thr
    


<210> 418
<211> 15
<212> PRT
<213> Homo sapiens

<400> 418
Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Asn Leu Ser Gln Ile
 1               5                  10                  15  


<210> 419
<211> 17
<212> PRT
<213> Homo sapiens

<400> 419
Lys Met Ser Asn Tyr Ser Leu Leu Ser Val Asp Tyr Val Val Asp Lys
 1               5                  10                  15      
Ala
    


<210> 420
<211> 35
<212> PRT
<213> Homo sapiens

<400> 420
Lys Leu Asp Asp Ile Ser Ser Asn Tyr Thr Glu Ser Phe Ser Thr Leu
 1               5                  10                  15      
Asp Glu Asn Asp Leu Leu Asn Pro Ser Glu Asp Ile Ile Ala Val Gln
            20                  25                  30          
Leu Lys Phe
        35  


<210> 421
<211> 20
<212> PRT
<213> Homo sapiens

<400> 421
Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn
 1               5                  10                  15      
Thr Asn Gly Ser
            20  


<210> 422
<211> 24
<212> PRT
<213> Homo sapiens

<400> 422
Lys Gly Ser Thr Pro Arg Asn Asp Pro Ser Val Ser Val Asp Tyr Asn
 1               5                  10                  15      
Thr Thr Glu Pro Ala Val Arg Trp
            20                  


<210> 423
<211> 29
<212> PRT
<213> Homo sapiens

<400> 423
Lys Glu Asp Gly Ser Gly Ser Ala Tyr Asp Lys Glu Ser Met Ala Ile
 1               5                  10                  15      
Ile Lys Leu Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu
            20                  25                  


<210> 424
<211> 14
<212> PRT
<213> Homo sapiens

<400> 424
Arg Val Ile Thr Val Gln Val Ala Asn Phe Thr Leu Arg Leu
 1               5                  10                  


<210> 425
<211> 14
<212> PRT
<213> Homo sapiens

<400> 425
Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile
 1               5                  10                  


<210> 426
<211> 24
<212> PRT
<213> Homo sapiens

<400> 426
Leu Glu Asn Ser Gly Arg Ser Lys Asn Phe Ser Tyr Asn Leu Gln Ser
 1               5                  10                  15      
Ala Thr Gln Pro Lys Asn Lys Thr
            20                  


<210> 427
<211> 8
<212> PRT
<213> Homo sapiens

<400> 427
Lys Tyr Asn Phe Ser Phe Arg Tyr
 1               5              


<210> 428
<211> 17
<212> PRT
<213> Homo sapiens

<400> 428
Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Ser Ala Val Pro Arg
 1               5                  10                  15      
Phe
    


<210> 429
<211> 18
<212> PRT
<213> Homo sapiens

<400> 429
Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Ile Ser Ser Thr Val Pro
 1               5                  10                  15      
Lys Met
        


<210> 430
<211> 18
<212> PRT
<213> Homo sapiens

<400> 430
Arg Phe Val Ala Cys Gln Met Glu Leu Leu His Ser Asn Gly Ser Gln
 1               5                  10                  15      
Arg Thr
        


<210> 431
<211> 14
<212> PRT
<213> Homo sapiens

<400> 431
Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile
 1               5                  10                  


<210> 432
<211> 24
<212> PRT
<213> Homo sapiens

<400> 432
Ile Glu Leu Asn Asp Ser Val Asn Glu Asn Ser Asp Thr Val Gly Gln
 1               5                  10                  15      
Ile Val His Tyr Ile Met Lys Asn
            20                  


<210> 433
<211> 12
<212> PRT
<213> Homo sapiens

<400> 433
Lys Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys
 1               5                  10          


<210> 434
<211> 12
<212> PRT
<213> Homo sapiens

<400> 434
Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe
 1               5                  10          


<210> 435
<211> 37
<212> PRT
<213> Homo sapiens

<400> 435
Arg Lys Glu Glu Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp
 1               5                  10                  15      
Pro Trp Ala Pro Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr
            20                  25                  30          
Ile Ala Gly Lys Asp
        35          


<210> 436
<211> 17
<212> PRT
<213> Homo sapiens

<400> 436
Arg Val Asn Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Phe Leu Arg
 1               5                  10                  15      
Glu
    


<210> 437
<211> 17
<212> PRT
<213> Homo sapiens

<400> 437
Arg Val Val Thr Val Ala Ala Leu Gly Thr Asn Ile Ser Ile His Lys
 1               5                  10                  15      
Asp
    


<210> 438
<211> 18
<212> PRT
<213> Homo sapiens

<400> 438
Arg Phe Gln Ala Phe Ala Asn Gly Ser Leu Leu Ile Pro Asp Phe Gly
 1               5                  10                  15      
Lys Leu
        


<210> 439
<211> 17
<212> PRT
<213> Homo sapiens

<400> 439
Arg Met Lys Ser Asp Ser Phe Leu Gln Glu Met Pro Asn Val Thr Asn
 1               5                  10                  15      
Ile
    


<210> 440
<211> 9
<212> PRT
<213> Homo sapiens

<400> 440
Arg Asn Ile Asn Tyr Thr Glu Arg Gly
 1               5                  


<210> 441
<211> 31
<212> PRT
<213> Homo sapiens

<400> 441
Arg Ser Phe Thr Asp Leu Leu Leu Asp Asp Gly Gln Asp Asn Asn Thr
 1               5                  10                  15      
Gln Ile Glu Glu Asp Thr Asp His Asn Tyr Tyr Ile Ser Arg Ile
            20                  25                  30      


<210> 442
<211> 21
<212> PRT
<213> Homo sapiens

<400> 442
Arg Ser Met Gln Gln Gln Glu Thr Asn Leu Leu Ala Asn Leu Thr Thr
 1               5                  10                  15      
Asn Asp Ala Arg Asp
            20      


<210> 443
<211> 32
<212> PRT
<213> Homo sapiens

<400> 443
Arg Leu Pro Ala Ser Leu Ala Glu Tyr Thr Val Thr Gln Leu Arg Pro
 1               5                  10                  15      
Asn Ala Thr Tyr Ser Val Cys Val Met Pro Leu Gly Pro Gly Arg Val
            20                  25                  30          


<210> 444
<211> 15
<212> PRT
<213> Homo sapiens

<400> 444
Arg Phe Asn Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 1               5                  10                  15  


<210> 445
<211> 24
<212> PRT
<213> Homo sapiens

<400> 445
Lys Thr Thr Cys Asn Pro Cys Pro Leu Gly Tyr Lys Glu Glu Asn Asn
 1               5                  10                  15      
Thr Gly Glu Cys Cys Gly Arg Cys
            20                  


<210> 446
<211> 20
<212> PRT
<213> Homo sapiens

<400> 446
Arg Leu Asp Arg Glu Asn Ile Ser Glu Tyr His Leu Thr Ala Val Ile
 1               5                  10                  15      
Val Asp Lys Asp
            20  


<210> 447
<211> 20
<212> PRT
<213> Homo sapiens

<400> 447
Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser Phe Thr Met Ile
 1               5                  10                  15      
Gly His Arg Ser
            20  


<210> 448
<211> 28
<212> PRT
<213> Homo sapiens

<400> 448
Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn
 1               5                  10                  15      
Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr
            20                  25              


<210> 449
<211> 35
<212> PRT
<213> Homo sapiens

<400> 449
Lys Leu Leu Leu Ser Gln Leu Asp Ser His Pro Ser His Ser Ala Val
 1               5                  10                  15      
Val Asn Trp Thr Ser Tyr Ala Ser Ser Ile Glu Ala Leu Ser Ser Gly
            20                  25                  30          
Asn Lys Glu
        35  


<210> 450
<211> 22
<212> PRT
<213> Homo sapiens

<400> 450
Met Cys Asp Asn Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn
 1               5                  10                  15      
Val Asn Trp Ser Lys Val
            20          


<210> 451
<211> 28
<212> PRT
<213> Homo sapiens

<400> 451
Lys Met Asn Gly Thr Leu Thr Ala Val Glu Ser Phe Leu Thr Ile His
 1               5                  10                  15      
Ser Gly Pro Glu Gly Leu Ser Ile His Asp Gly Thr
            20                  25              


<210> 452
<211> 24
<212> PRT
<213> Homo sapiens

<400> 452
Tyr His Gly Asn Gly Thr His Ser Glu Ser Leu Glu His His Gly Tyr
 1               5                  10                  15      
His Gly Asn Gly Thr Asp Arg Glu
            20                  


<210> 453
<211> 22
<212> PRT
<213> Homo sapiens

<400> 453
Arg Thr Lys Ser Asn Ser Leu Ser Glu Gln Leu Ala Ile Asn Thr Ser
 1               5                  10                  15      
Pro Asp Ala Val Lys Ala
            20          


<210> 454
<211> 23
<212> PRT
<213> Homo sapiens

<400> 454
Arg Arg Gln Gly Ala Tyr Asn Ile Asp Val Val Ala Val Val Asn Asp
 1               5                  10                  15      
Thr Val Gly Thr Met Met Gly
            20              


<210> 455
<211> 12
<212> PRT
<213> Homo sapiens

<400> 455
Arg Arg Gly Ala Ser Val Asn Arg Thr Thr Arg Thr
 1               5                  10          


<210> 456
<211> 26
<212> PRT
<213> Homo sapiens

<400> 456
Arg His Glu Lys Met Gly Ser Asn Ile Ser Gln Leu Thr Asp Lys Asn
 1               5                  10                  15      
Glu Leu Leu Thr Glu Gln Val His Lys Ala
            20                  25      


<210> 457
<211> 24
<212> PRT
<213> Homo sapiens

<400> 457
Lys Val Glu Leu Pro Pro Pro Asp Leu Gly Pro Ser Ser Ala Leu Asn
 1               5                  10                  15      
Gln Thr Leu Met Leu Leu Arg Glu
            20                  


<210> 458
<211> 27
<212> PRT
<213> Homo sapiens

<400> 458
Lys Ser Ser Arg Met Glu Thr Val Gly Asn Ala Ser Ser Ser Ser Asn
 1               5                  10                  15      
Pro Ser Ser Pro Gly Arg Ile Lys Gly Arg Leu
            20                  25          


<210> 459
<211> 26
<212> PRT
<213> Homo sapiens

<400> 459
Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu Ala Arg Leu Gly
 1               5                  10                  15      
Val Gln Asp Leu Phe Asn Ser Ser Lys Ala
            20                  25      


<210> 460
<211> 26
<212> PRT
<213> Homo sapiens

<400> 460
Lys Ile Leu Pro Ile Ser Leu Glu Pro Ser Ser Ser Thr Glu Pro Thr
 1               5                  10                  15      
Gln Ser Asn Leu Ser Val Thr Ala Lys Ile
            20                  25      


<210> 461
<211> 28
<212> PRT
<213> Homo sapiens

<400> 461
Lys His Trp Thr Asn Phe Val Ile Thr Glu Asn Ala Asn Asp Ala Ile
 1               5                  10                  15      
Gly Ile Leu Asn Asn Ser Ala Ser Phe Asn Lys Met
            20                  25              


<210> 462
<211> 23
<212> PRT
<213> Homo sapiens

<400> 462
Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val Val Tyr Asn Gly
 1               5                  10                  15      
Ser Ile Tyr Phe Asn Lys Phe
            20              


<210> 463
<211> 29
<212> PRT
<213> Homo sapiens

<400> 463
Arg Leu Ala Ser Pro Pro Ser Gln Gly Glu Val Pro Pro Gly Pro Leu
 1               5                  10                  15      
Pro Glu Ala Val Leu Ala Leu Tyr Asn Ser Thr Arg Asp
            20                  25                  


<210> 464
<211> 18
<212> PRT
<213> Homo sapiens

<400> 464
Lys Val Thr Val Arg Pro Gly Glu Ser Val Met Val Asn Ile Ser Ala
 1               5                  10                  15      
Lys Ala
        


<210> 465
<211> 23
<212> PRT
<213> Homo sapiens

<400> 465
Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp Gln Asn
 1               5                  10                  15      
Leu Ser Asp Leu Tyr Arg Trp
            20              


<210> 466
<211> 33
<212> PRT
<213> Homo sapiens

<400> 466
Arg Asp Cys Asp Pro Pro Gly Asn Pro Val His Gly Tyr Phe Glu Gly
 1               5                  10                  15      
Asn Asn Phe Thr Leu Gly Ser Thr Ile Ser Tyr Tyr Cys Glu Asp Arg
            20                  25                  30          
Tyr
    


<210> 467
<211> 20
<212> PRT
<213> Homo sapiens

<400> 467
Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly
 1               5                  10                  15      
Pro Ser Lys Ala
            20  


<210> 468
<211> 21
<212> PRT
<213> Homo sapiens

<400> 468
Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile
 1               5                  10                  15      
Gly Met Ala His Tyr
            20      


<210> 469
<211> 26
<212> PRT
<213> Homo sapiens

<400> 469
Lys Val His Asn Gly Ser Glu Ile Leu Phe Ser Tyr Phe Gln Asp Leu
 1               5                  10                  15      
Val Ile Thr Leu Pro Phe Glu Leu Arg Lys
            20                  25      


<210> 470
<211> 28
<212> PRT
<213> Homo sapiens

<400> 470
Lys Ala Gln Asn Gly Ile Ala Ile Met Val Tyr Thr Asn Ser Ser Asn
 1               5                  10                  15      
Thr Leu Tyr Trp Glu Leu Asn Gln Ala Val Arg Thr
            20                  25              


<210> 471
<211> 30
<212> PRT
<213> Homo sapiens

<400> 471
Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp Ile Asn Ser Thr
 1               5                  10                  15      
Ser Thr Leu Asn Gln Gly Leu Thr Ser His Gly Leu Arg Ala
            20                  25                  30  


<210> 472
<211> 25
<212> PRT
<213> Homo sapiens

<400> 472
Met Asp Thr Thr Ile Ser Ile Asn Asn Thr Val Ile Thr Pro Met Leu
 1               5                  10                  15      
Asn Pro Ile Ile Tyr Ser Leu Arg Asn
            20                  25  


<210> 473
<211> 18
<212> PRT
<213> Homo sapiens

<400> 473
Lys Leu Asn Val Ser Asp Leu Tyr Lys Leu Thr Asp Thr Val Ala Ile
 1               5                  10                  15      
Arg Glu
        


<210> 474
<211> 25
<212> PRT
<213> Homo sapiens

<400> 474
Lys Gly Asp Tyr Asn Asp Ser Val Gln Val Val Asp Cys Gly Leu Ser
 1               5                  10                  15      
Leu Asn Asp Thr Ala Phe Glu Lys Met
            20                  25  


<210> 475
<211> 20
<212> PRT
<213> Homo sapiens

<400> 475
Lys Ala Met Asn Ala Ser Ala Asn Ile Thr Ser Asp Gly Val Glu Val
 1               5                  10                  15      
Leu Gly Lys Met
            20  


<210> 476
<211> 18
<212> PRT
<213> Homo sapiens

<400> 476
Lys Leu Asn Ile Thr Asn Ile Trp Val Leu Asp Tyr Phe Gly Gly Pro
 1               5                  10                  15      
Lys Ile
        


<210> 477
<211> 18
<212> PRT
<213> Homo sapiens

<400> 477
Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe Thr Asp Pro Gln Leu
 1               5                  10                  15      
Arg Arg
        


<210> 478
<211> 19
<212> PRT
<213> Homo sapiens

<400> 478
Lys Ile Ala Val Gln Phe Gly Pro Gly Phe Ser Trp Ile Ala Asn Phe
 1               5                  10                  15      
Thr Lys Ala
            


<210> 479
<211> 13
<212> PRT
<213> Homo sapiens

<400> 479
Arg Phe Asn Ser Thr Glu Tyr Gln Val Val Thr Arg Val
 1               5                  10              


<210> 480
<211> 28
<212> PRT
<213> Homo sapiens

<400> 480
Lys Asp Val Asp Lys Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu
 1               5                  10                  15      
Asn Glu Ser Leu Leu Leu Glu Asp Asn Ile Arg Met
            20                  25              


<210> 481
<211> 36
<212> PRT
<213> Homo sapiens

<400> 481
Lys Ala Leu Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile Ser Thr
 1               5                  10                  15      
Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu Thr Glu
            20                  25                  30          
Ile Leu Lys Ala
        35      


<210> 482
<211> 25
<212> PRT
<213> Homo sapiens

<400> 482
Lys Gln Leu Asn Val Gln Met Asn Met Ser Asn Val Met Gly Asn Thr
 1               5                  10                  15      
Thr Trp Thr Thr Ser Gly Leu Lys Ser
            20                  25  


<210> 483
<211> 17
<212> PRT
<213> Homo sapiens

<400> 483
Arg Ala Ala Tyr Asn Val Thr Leu Leu Asn Phe Met Asp Pro Gln Lys
 1               5                  10                  15      
Met
    


<210> 484
<211> 33
<212> PRT
<213> Homo sapiens

<400> 484
Ala Gly Met Asn Pro Gly Met Leu Ala Ala Gly Asn Gly Gln Gly Ile
 1               5                  10                  15      
Met Pro Asn Gln Val Met Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg
            20                  25                  30          
Gln
    


<210> 485
<211> 13
<212> PRT
<213> Homo sapiens

<400> 485
Lys Leu Phe Ser Asp Ile Glu Asn Ile Ser Glu Glu Thr
 1               5                  10              


<210> 486
<211> 19
<212> PRT
<213> Homo sapiens

<400> 486
Lys Tyr Glu Phe Cys Pro Phe His Asn Val Thr Gln His Glu Gln Thr
 1               5                  10                  15      
Phe Arg Trp
            


<210> 487
<211> 30
<212> PRT
<213> Homo sapiens

<400> 487
Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe Ala Ser Leu Gly
 1               5                  10                  15      
Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu Arg Val
            20                  25                  30  


<210> 488
<211> 23
<212> PRT
<213> Homo sapiens

<400> 488
Arg Leu Ala Leu Thr Pro Ala His Leu Leu Phe Thr Ala Asp Asn His
 1               5                  10                  15      
Thr Glu Pro Ala Ala Arg Phe
            20              


<210> 489
<211> 17
<212> PRT
<213> Homo sapiens

<400> 489
Gln Leu Met Asn Ile Thr Ala Gly Thr Ser His Val Met Ile Ser Arg
 1               5                  10                  15      
Arg
    


<210> 490
<211> 18
<212> PRT
<213> Homo sapiens

<400> 490
Arg Asn Arg Asn Leu Ser Gly Gly Val Leu Met Gly Phe Met Leu Asn
 1               5                  10                  15      
Arg Ile
        


<210> 491
<211> 23
<212> PRT
<213> Homo sapiens

<400> 491
Arg Gly Leu Gln Pro Thr Leu Thr Asn Pro Gly Glu Cys Arg Pro Asn
 1               5                  10                  15      
Phe Thr Cys Ala Cys Arg Lys
            20              


<210> 492
<211> 20
<212> PRT
<213> Homo sapiens

<400> 492
Lys Arg Ser Val Leu Pro Pro Asp Gly Asn Gly Ser Pro Val Leu Pro
 1               5                  10                  15      
Asp Lys Arg Asn
            20  


<210> 493
<211> 19
<212> PRT
<213> Homo sapiens

<400> 493
Arg Lys Val Glu Val Glu Pro Leu Asn Ser Thr Ala Val His Val Tyr
 1               5                  10                  15      
Trp Lys Leu
            


<210> 494
<211> 25
<212> PRT
<213> Homo sapiens

<400> 494
Asp Gly Glu Ser Cys Ser Asn Ser Ser His Gln Gln Ile Leu Glu Thr
 1               5                  10                  15      
Gly Glu Gly Ser Pro Ser Leu Lys Ile
            20                  25  


<210> 495
<211> 17
<212> PRT
<213> Homo sapiens

<400> 495
Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile Ala Leu Asn Glu Lys Arg
 1               5                  10                  15      
Val
    


<210> 496
<211> 23
<212> PRT
<213> Homo sapiens

<400> 496
Arg Tyr Thr Leu Val Phe Asn Ser Ser Ser Glu Arg Asn Val Ser Leu
 1               5                  10                  15      
Thr Glu His Lys Lys Lys Gln
            20              


<210> 497
<211> 23
<212> PRT
<213> Homo sapiens

<400> 497
Arg Val Gly Ser Ser Pro Lys Ile Asn Val Ser Pro Phe Tyr Gln Asn
 1               5                  10                  15      
Gln Thr Ser Thr Gln Arg Ser
            20              


<210> 498
<211> 36
<212> PRT
<213> Homo sapiens

<400> 498
Arg Arg Phe Ile Pro Pro Ala Arg Met Met Ser Thr Glu Ser Ala Asn
 1               5                  10                  15      
Ser Phe Thr Leu Ile Gly Glu Ala Ser Asp Gly Gly Thr Met Glu Asn
            20                  25                  30          
Leu Ser Arg Arg
        35      


<210> 499
<211> 17
<212> PRT
<213> Homo sapiens

<400> 499
Arg Leu Asn Val Asn Ala Thr Asp Ser Ser Ser Thr Ser Asn His Lys
 1               5                  10                  15      
Gln
    


<210> 500
<211> 14
<212> PRT
<213> Homo sapiens

<400> 500
Arg Gly Leu Ala Gly Val Glu Asn Val Thr Glu Leu Lys Lys
 1               5                  10                  


<210> 501
<211> 24
<212> PRT
<213> Homo sapiens

<400> 501
Arg Glu Pro Ser Asp Pro Thr Ser Asn Arg Ser Thr Phe His Pro Gly
 1               5                  10                  15      
Asp Ser Gln Lys Pro Val Lys Arg
            20                  


<210> 502
<211> 31
<212> PRT
<213> Homo sapiens

<400> 502
Arg Cys Gly Glu Pro Pro Ser Ile Met Asn Gly Tyr Ala Ser Gly Ser
 1               5                  10                  15      
Asn Tyr Ser Phe Gly Ala Met Val Ala Tyr Ser Cys Asn Lys Gly
            20                  25                  30      


<210> 503
<211> 37
<212> PRT
<213> Homo sapiens

<400> 503
Met Ser Ala Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly
 1               5                  10                  15      
Ser Met Asn Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu
            20                  25                  30          
Ala Gly Met Ser Pro
        35          


<210> 504
<211> 26
<212> PRT
<213> Homo sapiens

<400> 504
Met Met Asn Tyr Gly Gln Ser Met Ser Gly Gly Asn Gly Gln Ala Ala
 1               5                  10                  15      
Asn Gln Thr Leu Ser Pro Gln Met Trp Lys
            20                  25      


<210> 505
<211> 20
<212> PRT
<213> Homo sapiens

<400> 505
Met Asp Phe Asn Leu Ser Gly Asp Ser Asp Gly Ser Ala Gly Val Ser
 1               5                  10                  15      
Glu Ser Arg Ile
            20  


<210> 506
<211> 27
<212> PRT
<213> Homo sapiens

<400> 506
Lys Arg Val Tyr Ser Leu Met Glu Asn Asn Ser Tyr Pro Arg Phe Leu
 1               5                  10                  15      
Glu Ser Glu Phe Tyr Gln Asp Leu Cys Lys Lys
            20                  25          


<210> 507
<211> 12
<212> PRT
<213> Homo sapiens

<400> 507
Lys Gln Asn Thr Thr Leu Gly Leu Ser Glu Arg Pro
 1               5                  10          


<210> 508
<211> 27
<212> PRT
<213> Homo sapiens

<400> 508
Lys Asn Tyr Ser Pro Tyr Tyr Asn Thr Ile Asp Asp Leu Lys Asp Gln
 1               5                  10                  15      
Ile Val Asp Leu Thr Val Gly Asn Asn Lys Thr
            20                  25          


<210> 509
<211> 14
<212> PRT
<213> Homo sapiens

<400> 509
Lys Asn Leu Ser Gly Pro Asp Asp Leu Leu Ile Asp Lys Asn
 1               5                  10                  


<210> 510
<211> 20
<212> PRT
<213> Homo sapiens

<400> 510
Lys Asn Gly Thr Val Asp Gly Thr Ser Glu Asn Thr Glu Asp Gly Leu
 1               5                  10                  15      
Asp Arg Lys Asp
            20  


<210> 511
<211> 35
<212> PRT
<213> Homo sapiens

<400> 511
Lys Gly Gly Met Asn Gly Tyr His Val Asn Gly Ala Ile Asn Asp Thr
 1               5                  10                  15      
Glu Ser Val Asp Ser Leu Ser Glu Gly Leu Glu Thr Leu Ser Ile Asp
            20                  25                  30          
Ala Arg Glu
        35  


<210> 512
<211> 15
<212> PRT
<213> Homo sapiens

<400> 512
Lys Glu Val Leu Leu Lys Thr Asn Leu Ser Gly Arg Gln Ser Pro
 1               5                  10                  15  


<210> 513
<211> 25
<212> PRT
<213> Homo sapiens

<400> 513
Lys Glu Met Tyr Gln Pro Glu Asp Asp Asn Asn Ser Asp Val Thr Ser
 1               5                  10                  15      
Asp Asp Asp Met Thr Arg Asn Arg Arg
            20                  25  


<210> 514
<211> 31
<212> PRT
<213> Homo sapiens

<400> 514
Val Asn Leu Ser Leu Ile Phe Ile Ile Ala Leu Gly Ser Ile Ala Gly
 1               5                  10                  15      
Ile Leu Phe Val Thr Met Ile Phe Val Ala Ile Lys Cys Lys Arg
            20                  25                  30      


<210> 515
<211> 18
<212> PRT
<213> Homo sapiens

<400> 515
Arg Arg Thr Glu Lys Leu Phe Phe Thr Ile Leu Ser Pro Asn Gln Ser
 1               5                  10                  15      
Lys Pro
        


<210> 516
<211> 17
<212> PRT
<213> Homo sapiens

<400> 516
Arg Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys
 1               5                  10                  15      
Tyr
    


<210> 517
<211> 36
<212> PRT
<213> Homo sapiens

<400> 517
Arg Phe Asp Phe Gln Gly Thr Cys Glu Tyr Leu Leu Ser Ala Pro Cys
 1               5                  10                  15      
His Gly Pro Pro Leu Gly Ala Glu Asn Phe Thr Val Thr Val Ala Asn
            20                  25                  30          
Glu His Arg Gly
        35      


<210> 518
<211> 27
<212> PRT
<213> Homo sapiens

<400> 518
Arg Glu Cys Phe Asn Ile Gly Asn Phe Asn Ser Met Met Ala Ile Ile
 1               5                  10                  15      
Ser Gly Met Asn Leu Ser Pro Val Ala Arg Leu
            20                  25          


<210> 519
<211> 21
<212> PRT
<213> Homo sapiens

<400> 519
Met Val Asp Pro Glu Met Leu Pro Pro Lys Thr Ala Arg Gln Thr Glu
 1               5                  10                  15      
Asn Val Ser Arg Thr
            20      


<210> 520
<211> 15
<212> PRT
<213> Homo sapiens

<400> 520
Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp Arg Arg
 1               5                  10                  15  


<210> 521
<211> 19
<212> PRT
<213> Homo sapiens

<400> 521
Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp
 1               5                  10                  15      
Gly Arg Val
            


<210> 522
<211> 25
<212> PRT
<213> Homo sapiens

<400> 522
Lys Glu Ser Gly Leu Asp Asn Cys Thr Arg Ile Ser Gly Phe Leu Ala
 1               5                  10                  15      
Phe Lys Asn Phe Asp Tyr Gly Ala Met
            20                  25  


<210> 523
<211> 11
<212> PRT
<213> Homo sapiens

<400> 523
Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys
 1               5                  10      


<210> 524
<211> 8
<212> PRT
<213> Homo sapiens

<400> 524
Arg Cys Asn Tyr Ser Ile Arg Val
 1               5              


<210> 525
<211> 38
<212> PRT
<213> Homo sapiens

<400> 525
Lys Ser Ser Val Ile Thr Leu Asn Thr Asn Ala Glu Leu Phe Asn Gln
 1               5                  10                  15      
Ser Asp Ile Val Ala His Leu Leu Ser Ser Ser Ser Ser Val Ile Asp
            20                  25                  30          
Ala Leu Gln Tyr Lys Leu
        35              


<210> 526
<211> 15
<212> PRT
<213> Homo sapiens

<400> 526
Lys Leu Gln Asn Leu Thr Leu Pro Thr Asn Ala Ser Ile Lys Phe
 1               5                  10                  15  


<210> 527
<211> 22
<212> PRT
<213> Homo sapiens

<400> 527
Lys Glu Lys Pro Pro Asn Glu Asn Cys Asn Asn Asn Ser Pro Glu Ser
 1               5                  10                  15      
Ser Leu Leu Pro Arg Ala
            20          


<210> 528
<211> 24
<212> PRT
<213> Homo sapiens

<400> 528
Lys Glu His Ala Val Phe Thr Ser Asn Gln Glu Glu Gln Asp Pro Ala
 1               5                  10                  15      
Asn His Thr Cys Gly Val Lys Ser
            20                  


<210> 529
<211> 26
<212> PRT
<213> Homo sapiens

<400> 529
Glu Phe Ile His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr
 1               5                  10                  15      
Asp Asn Val Gln Phe His Val Asp Lys Lys
            20                  25      


<210> 530
<211> 18
<212> PRT
<213> Homo sapiens

<400> 530
Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser Ser Ser Asn Ser Thr
 1               5                  10                  15      
Arg Glu
        


<210> 531
<211> 25
<212> PRT
<213> Homo sapiens

<400> 531
Lys Leu Asn Asn Pro Lys Asp Phe Gln Glu Leu Asn Lys Gln Thr Lys
 1               5                  10                  15      
Lys Asn Met Thr Ile Asp Gly Lys Glu
            20                  25  


<210> 532
<211> 16
<212> PRT
<213> Homo sapiens

<400> 532
Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn Gln Thr Tyr Lys Met
 1               5                  10                  15      


<210> 533
<211> 16
<212> PRT
<213> Homo sapiens

<400> 533
Arg Val Asp Leu Glu Asp Phe Glu Asn Asn Thr Ala Tyr Ala Lys Tyr
 1               5                  10                  15      


<210> 534
<211> 32
<212> PRT
<213> Homo sapiens

<400> 534
Arg Thr Ala Gly Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu
 1               5                  10                  15      
Asn Trp Thr Gly Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe
            20                  25                  30          


<210> 535
<211> 25
<212> PRT
<213> Homo sapiens

<400> 535
Lys Leu Asp Ser Phe Gly Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr
 1               5                  10                  15      
Ser Phe Leu Thr Thr Phe Phe Lys Glu
            20                  25  


<210> 536
<211> 16
<212> PRT
<213> Homo sapiens

<400> 536
Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu His Val Lys Glu
 1               5                  10                  15      


<210> 537
<211> 18
<212> PRT
<213> Homo sapiens

<400> 537
Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser Ser Met Phe Leu
 1               5                  10                  15      
Lys Gly
        


<210> 538
<211> 18
<212> PRT
<213> Homo sapiens

<400> 538
Arg Ile Leu Ile Trp Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr
 1               5                  10                  15      
Arg Asn
        


<210> 539
<211> 12
<212> PRT
<213> Homo sapiens

<400> 539
Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile
 1               5                  10          


<210> 540
<211> 33
<212> PRT
<213> Homo sapiens

<400> 540
Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val Thr Gly Pro Ile
 1               5                  10                  15      
Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr Pro Leu Pro Lys
            20                  25                  30          
Ser
    


<210> 541
<211> 12
<212> PRT
<213> Homo sapiens

<400> 541
Arg Val Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr
 1               5                  10          


<210> 542
<211> 12
<212> PRT
<213> Homo sapiens

<400> 542
Arg Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn
 1               5                  10          


<210> 543
<211> 16
<212> PRT
<213> Homo sapiens

<400> 543
Arg Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr
 1               5                  10                  15      


<210> 544
<211> 20
<212> PRT
<213> Homo sapiens

<400> 544
Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu Ser Leu
 1               5                  10                  15      
Glu Val Arg Asn
            20  


<210> 545
<211> 23
<212> PRT
<213> Homo sapiens

<400> 545
Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn Val Ser Phe Glu Cys Glu
 1               5                  10                  15      
Asp Gly Phe Ile Leu Arg Gly
            20              


<210> 546
<211> 16
<212> PRT
<213> Homo sapiens

<400> 546
Arg Ala Gly Pro Asn Gly Thr Leu Phe Val Ala Asp Ala Tyr Lys Gly
 1               5                  10                  15      


<210> 547
<211> 16
<212> PRT
<213> Homo sapiens

<400> 547
Lys Glu Asp Ala Ala Val Asn Cys Thr Asp Ile Ser Val Gln Lys Thr
 1               5                  10                  15      


<210> 548
<211> 17
<212> PRT
<213> Homo sapiens

<400> 548
Arg Leu Met Ser Thr Glu Ala Ser Gln Asn Ile Thr Tyr His Cys Lys
 1               5                  10                  15      
Asn
    


<210> 549
<211> 14
<212> PRT
<213> Homo sapiens

<400> 549
Lys Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn
 1               5                  10                  


<210> 550
<211> 12
<212> PRT
<213> Homo sapiens

<400> 550
Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly
 1               5                  10          


<210> 551
<211> 18
<212> PRT
<213> Homo sapiens

<400> 551
Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val Lys Glu
 1               5                  10                  15      
Arg Gly
        


<210> 552
<211> 33
<212> PRT
<213> Homo sapiens

<400> 552
Lys Val Thr Glu Leu Gln Leu Thr Ser Ser Glu Leu Asp Phe Gln Pro
 1               5                  10                  15      
Gln Gln Glu Leu Met Leu Gln Ile Thr Asn Ala Ser Leu Gly Leu Arg
            20                  25                  30          
Phe
    


<210> 553
<211> 22
<212> PRT
<213> Homo sapiens

<400> 553
Arg Ser Tyr Ser Glu Ser Ser Ser Thr Ser Ser Ser Glu Ser Leu Asn
 1               5                  10                  15      
Ser Ser Ala Pro Arg Gly
            20          


<210> 554
<211> 18
<212> PRT
<213> Homo sapiens

<400> 554
Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu Gly Met Leu Asn
 1               5                  10                  15      
Arg Thr
        


<210> 555
<211> 10
<212> PRT
<213> Homo sapiens

<400> 555
Arg Val Leu Asn Val Ser Gln Asn Leu Leu
 1               5                  10  


<210> 556
<211> 22
<212> PRT
<213> Homo sapiens

<400> 556
Arg Ser Cys Leu Ser Cys Pro Glu Asn Thr Ser Thr Val Lys Arg Gly
 1               5                  10                  15      
Ala Val Asn Ile Ser Ala
            20          


<210> 557
<211> 16
<212> PRT
<213> Homo sapiens

<400> 557
Arg Ser Cys Leu Ser Cys Pro Glu Asn Thr Ser Thr Val Lys Arg Gly
 1               5                  10                  15      


<210> 558
<211> 30
<212> PRT
<213> Homo sapiens

<400> 558
Lys Ile Lys Arg Asn Phe Ser Ser Gly Thr Ile Pro Gly Thr Pro Gly
 1               5                  10                  15      
Pro Asn Gly Glu Asp Gly Val Glu Gln Thr Ala Ile Lys Val
            20                  25                  30  


<210> 559
<211> 21
<212> PRT
<213> Homo sapiens

<400> 559
Lys Gly Arg Asn Thr Ser Ser Ala Val Glu Met Pro Phe Arg Asn Ser
 1               5                  10                  15      
Lys Arg Ser Arg Leu
            20      


<210> 560
<211> 40
<212> PRT
<213> Homo sapiens

<400> 560
Met Pro Ser Ser Thr Leu Pro Gly Trp Pro Gly Ser Ser Gly Gly Pro
 1               5                  10                  15      
Val Ser Arg Pro Ser Ser Leu Glu Ser Ser Arg Asn Thr Ser Ser Asn
            20                  25                  30          
Ser Ser Pro Leu Asn Leu Lys Gly
        35                  40  


<210> 561
<211> 18
<212> PRT
<213> Homo sapiens

<400> 561
Arg Gly Ala Phe Phe Pro Leu Thr Glu Arg Asn Trp Ser Leu Pro Asn
 1               5                  10                  15      
Arg Ala
        


<210> 562
<211> 9
<212> PRT
<213> Homo sapiens

<400> 562
Lys Leu Ile Ser Asn Cys Ser Lys Phe
 1               5                  


<210> 563
<211> 18
<212> PRT
<213> Homo sapiens

<400> 563
Met Ser Leu Phe Leu Ser Asn Leu Ser Thr Asn Asp Ser Ser Leu Trp
 1               5                  10                  15      
Lys Glu
        


<210> 564
<211> 15
<212> PRT
<213> Homo sapiens

<400> 564
Ala Thr Leu Gly Thr Thr Ala Leu Asn Asn Ser Asn Pro Lys Asp
 1               5                  10                  15  


<210> 565
<211> 14
<212> PRT
<213> Homo sapiens

<400> 565
Arg Gly Asn Glu Thr Leu His Tyr Glu Thr Phe Gly Lys Ala
 1               5                  10                  


<210> 566
<211> 11
<212> PRT
<213> Homo sapiens

<400> 566
Arg Ala Asn Leu Thr Val Val Leu Leu Arg Gly
 1               5                  10      


<210> 567
<211> 15
<212> PRT
<213> Homo sapiens

<400> 567
Lys Glu Ala Pro Tyr Phe Tyr Asn Asp Thr Val Thr Phe Lys Cys
 1               5                  10                  15  


<210> 568
<211> 26
<212> PRT
<213> Homo sapiens

<400> 568
Lys Arg Lys Asn Ser Thr Ser Ser Thr Ser Asn Ser Ser Ala Gly Asn
 1               5                  10                  15      
Asn Ala Asn Ser Thr Gly Ser Lys Lys Lys
            20                  25      


<210> 569
<211> 29
<212> PRT
<213> Homo sapiens

<400> 569
Lys Glu Tyr Tyr Leu Met Glu Asn Pro Gln Glu Pro Asp Ala Pro Ile
 1               5                  10                  15      
Val Thr Phe Phe Pro Leu Ile Asn Asp Thr Phe Arg Lys
            20                  25                  


<210> 570
<211> 15
<212> PRT
<213> Homo sapiens

<400> 570
Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr Thr Val Lys Asp
 1               5                  10                  15  


<210> 571
<211> 9
<212> PRT
<213> Homo sapiens

<400> 571
Arg Gly His Val Asn Ile Thr Arg Ser
 1               5                  


<210> 572
<211> 9
<212> PRT
<213> Homo sapiens

<400> 572
Pro Gly Phe Asn Asn Thr Glu Arg Thr
 1               5                  


<210> 573
<211> 9
<212> PRT
<213> Homo sapiens

<400> 573
Arg Thr Leu Leu Asn Ala Ser Arg Ser
 1               5                  


<210> 574
<211> 29
<212> PRT
<213> Homo sapiens

<400> 574
Lys Ser Leu Asp Leu Ser His Asn Leu Ile Ser Asp Phe Ala Trp Ser
 1               5                  10                  15      
Asp Leu His Asn Leu Ser Ala Leu Gln Leu Leu Lys Met
            20                  25                  


<210> 575
<211> 26
<212> PRT
<213> Homo sapiens

<400> 575
Lys Ala Asn Tyr Asn Leu Pro Ile Met Val Thr Asp Ser Gly Lys Pro
 1               5                  10                  15      
Pro Met Thr Asn Ile Thr Asp Leu Arg Val
            20                  25      


<210> 576
<211> 21
<212> PRT
<213> Homo sapiens

<400> 576
Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn
 1               5                  10                  15      
Ser Thr Ser Val Ser
            20      


<210> 577
<211> 15
<212> PRT
<213> Homo sapiens

<400> 577
Arg Ile Val Ala Ala Arg Leu Asn Gly Ser Leu Asp Phe Phe Ser
 1               5                  10                  15  


<210> 578
<211> 18
<212> PRT
<213> Homo sapiens

<400> 578
Arg Val Glu Gly Leu Phe Leu Thr Leu Ser Gly Ser Asn Leu Thr Val
 1               5                  10                  15      
Lys Val
        


<210> 579
<211> 15
<212> PRT
<213> Homo sapiens

<400> 579
Arg Thr Thr Ala Ser Thr Asn Met Asn Ala Ser Ser Ser Arg Ser
 1               5                  10                  15  


<210> 580
<211> 16
<212> PRT
<213> Homo sapiens

<400> 580
Arg Thr Lys Ser Gln Ser Lys Leu Asp Arg Asn Thr Ser Phe Arg Leu
 1               5                  10                  15      


<210> 581
<211> 19
<212> PRT
<213> Homo sapiens

<400> 581
Arg Arg Gly Ala Ser Val Asn Arg Thr Thr Arg Thr Asn Ser Thr Pro
 1               5                  10                  15      
Leu Arg Ala
            


<210> 582
<211> 11
<212> PRT
<213> Homo sapiens

<400> 582
Arg Gln Asn Ser Ser Pro His Leu Pro Lys Leu
 1               5                  10      


<210> 583
<211> 25
<212> PRT
<213> Homo sapiens

<400> 583
Arg Gln Met Gly Gly Asn Thr Asn Thr Gly Ala Ala Leu Asn Phe Thr
 1               5                  10                  15      
Leu Ser Leu Leu Gln Lys Ala Lys Lys
            20                  25  


<210> 584
<211> 27
<212> PRT
<213> Homo sapiens

<400> 584
Arg Met Ser Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly
 1               5                  10                  15      
Asn Asn Gln Ser Gln Gly Asn Met Gln Arg Glu
            20                  25          


<210> 585
<211> 44
<212> PRT
<213> Homo sapiens

<400> 585
Arg Met Gly Met Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp
 1               5                  10                  15      
Gly Leu Gly Gly Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr
            20                  25                  30          
Gly Gln Gly Gly Met Ser Gly Gly Gly Trp Arg Gly
        35                  40                  


<210> 586
<211> 12
<212> PRT
<213> Homo sapiens

<400> 586
Arg Leu His Asn Gly Asn Ala Ser Pro Pro Arg Val
 1               5                  10          


<210> 587
<211> 25
<212> PRT
<213> Homo sapiens

<400> 587
Arg Leu Phe Cys Asp Pro Thr Phe Leu Pro Glu Asn Asp Ser Leu Phe
 1               5                  10                  15      
Tyr Asn Arg Leu Leu Pro Gly Lys Val
            20                  25  


<210> 588
<211> 29
<212> PRT
<213> Homo sapiens

<400> 588
Arg Ile Ser Glu Ser Gly Ile Lys Lys Met Cys Arg Asn Ile Phe Val
 1               5                  10                  15      
Leu Gln Gln Asn Leu Thr Asn Ile Thr Met Ser Arg Glu
            20                  25                  


<210> 589
<211> 19
<212> PRT
<213> Homo sapiens

<400> 589
Arg Ile Gly Val Ser Phe Ile Asp Asp Gly Ser Asn Ala Thr Asp Leu
 1               5                  10                  15      
Leu Arg Lys
            


<210> 590
<211> 27
<212> PRT
<213> Homo sapiens

<400> 590
Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu Glu
 1               5                  10                  15      
Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala
            20                  25          


<210> 591
<211> 26
<212> PRT
<213> Homo sapiens

<400> 591
Arg Gly Phe Asn Met Ser Ile Pro Met Pro Gly His Pro Val Asn Phe
 1               5                  10                  15      
Ser Ser Val Thr Leu Glu Gln Ala Arg Arg
            20                  25      


<210> 592
<211> 22
<212> PRT
<213> Homo sapiens

<400> 592
Arg Asp Gly Val Leu Leu Cys Gln Leu Leu His Asn Leu Ser Pro Gly
 1               5                  10                  15      
Ser Ile Asp Leu Lys Asp
            20          


<210> 593
<211> 15
<212> PRT
<213> Homo sapiens

<400> 593
Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys Asn
 1               5                  10                  15  


<210> 594
<211> 22
<212> PRT
<213> Homo sapiens

<400> 594
Met Thr Asn Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn
 1               5                  10                  15      
Thr Tyr Phe Leu Arg Lys
            20          


<210> 595
<211> 27
<212> PRT
<213> Homo sapiens

<400> 595
Met Ser Gln Ser Met Gly Gly Asp Asn Leu Ser Ser Leu Asp Thr Asn
 1               5                  10                  15      
Glu Ala Glu Ile Glu Pro Glu Asn Met Arg Glu
            20                  25          


<210> 596
<211> 24
<212> PRT
<213> Homo sapiens

<400> 596
Met Arg Ala Asn Gly Asn Thr Thr Ser Asn Lys Asn Ser Ala Ala Met
 1               5                  10                  15      
Asp Ala Glu Ile Val Leu Arg Ser
            20                  


<210> 597
<211> 18
<212> PRT
<213> Homo sapiens

<400> 597
Met Met Leu Gly Asp Ala Lys Ile Gly Asn Asn Ser Val Ser Ser Leu
 1               5                  10                  15      
Lys Asn
        


<210> 598
<211> 20
<212> PRT
<213> Homo sapiens

<400> 598
Met Lys Lys Val His Val Asn Ser Val Asn Pro Asn Tyr Thr Gly Gly
 1               5                  10                  15      
Glu Pro Lys Arg
            20  


<210> 599
<211> 16
<212> PRT
<213> Homo sapiens

<400> 599
Met Glu Val Cys Asn Asn Glu Thr Ile Ser Val Ser Ser Tyr Lys Ile
 1               5                  10                  15      


<210> 600
<211> 22
<212> PRT
<213> Homo sapiens

<400> 600
Met Ala Lys Ser Ala Leu Arg Glu Asn Gly Thr Asn Ser Glu Thr Phe
 1               5                  10                  15      
Arg Gln Arg Phe Arg Arg
            20          


<210> 601
<211> 19
<212> PRT
<213> Homo sapiens

<400> 601
Lys Tyr Asn Asn Gly Ser Thr Glu Leu His Ser Ser Ser Val Gly Leu
 1               5                  10                  15      
Ala Lys Ala
            


<210> 602
<211> 19
<212> PRT
<213> Homo sapiens

<400> 602
Lys Thr Asn Gln Gly Ile Pro Glu Leu Asn Ala Ser Ser Val Gly Met
 1               5                  10                  15      
Ala Lys Ala
            


<210> 603
<211> 31
<212> PRT
<213> Homo sapiens

<400> 603
Lys Thr Leu Ser Thr Lys Thr Pro Ser Ala Ala Gln Asn Pro Met Met
 1               5                  10                  15      
Thr Asn Ala Ser Ala Thr Gln Ala Thr Leu Thr Ala Gln Lys Phe
            20                  25                  30      


<210> 604
<211> 25
<212> PRT
<213> Homo sapiens

<400> 604
Lys Ser Val Ser Thr Ser Ser Pro Ala Gly Ala Ala Ile Ala Ser Thr
 1               5                  10                  15      
Ser Gly Ala Ser Asn Asn Ser Ser Ser
            20                  25  


<210> 605
<211> 26
<212> PRT
<213> Homo sapiens

<400> 605
Lys Ser Ala Met Pro Ile Glu Val Met Met Asn Glu Thr Ala Gln Gln
 1               5                  10                  15      
Asn Met Glu Asn His Pro Val Ile Arg Thr
            20                  25      


<210> 606
<211> 26
<212> PRT
<213> Homo sapiens

<400> 606
Lys Arg Glu Glu Glu Glu Glu Glu Glu Gly Ser Ile Met Asn Gly Ser
 1               5                  10                  15      
Thr Ala Glu Asp Glu Glu Gln Thr Arg Ser
            20                  25      


<210> 607
<211> 13
<212> PRT
<213> Homo sapiens

<400> 607
Lys Asn Pro Thr Thr Glu Glu Thr Val Leu Thr Lys Thr
 1               5                  10              


<210> 608
<211> 28
<212> PRT
<213> Homo sapiens

<400> 608
Lys Asn Lys Thr Ser Thr Ala Ser Ser Met Val Ala Ser Ala Glu Gln
 1               5                  10                  15      
Pro Ser Gly Ser Val Glu Glu Glu Leu Ser Lys Lys
            20                  25              


<210> 609
<211> 34
<212> PRT
<213> Homo sapiens

<400> 609
Lys Met Asn Met Asn Val Met Glu Glu Ala Ile Gly Tyr Phe Glu Gln
 1               5                  10                  15      
Gln Leu Ala Met Leu Gln Gln Leu Ser Gly Asn Glu Ser Val Leu Asp
            20                  25                  30          
Arg Gly
        


<210> 610
<211> 14
<212> PRT
<213> Homo sapiens

<400> 610
Lys Leu Gln Thr Thr Asn Thr Thr Arg Ser Val Leu Lys Asp
 1               5                  10                  


<210> 611
<211> 34
<212> PRT
<213> Homo sapiens

<400> 611
Lys Leu Leu Lys Gly Asp Ile Asp Ile Gly Ser Gln Asn Gly Thr Asp
 1               5                  10                  15      
Leu Phe Gly Phe Gly Asn Thr His Glu Tyr Pro Asp Leu Gln Met Ile
            20                  25                  30          
Leu Ser
        


<210> 612
<211> 17
<212> PRT
<213> Homo sapiens

<400> 612
Lys Leu Ala Leu Leu Asn Ala Ser Leu Val Lys Gly Asn Leu Ser Arg
 1               5                  10                  15      
Val
    


<210> 613
<211> 22
<212> PRT
<213> Homo sapiens

<400> 613
Lys Lys Asp Ala Glu Asn His Glu Ala Gln Leu Lys Asn Gly Ser Leu
 1               5                  10                  15      
Asp Gln Gly Ser Arg Ile
            20          


<210> 614
<211> 24
<212> PRT
<213> Homo sapiens

<400> 614
Lys His Pro Glu Asn Asn Gln Lys Ser Glu Asn Asn Gln Lys Leu Leu
 1               5                  10                  15      
Thr Gly Ala Asn Ser Ser Arg Phe
            20                  


<210> 615
<211> 22
<212> PRT
<213> Homo sapiens

<400> 615
Lys His Phe Gly Glu Phe Phe Asn Leu Asn Gln Thr Val Gln Ser Thr
 1               5                  10                  15      
Ile Glu Asp Ile Lys Val
            20          


<210> 616
<211> 22
<212> PRT
<213> Homo sapiens

<400> 616
Asp Arg Pro Pro Ser Pro Thr Asp Asn Ile Ser Arg Tyr Ser Phe Asp
 1               5                  10                  15      
Asn Leu Pro Glu Lys Tyr
            20          


<210> 617
<211> 17
<212> PRT
<213> Homo sapiens

<400> 617
Ala Leu Cys Asp Gln Glu Gly Trp Asp Thr Pro Ile Asn Tyr Ser Lys
 1               5                  10                  15      
Thr
    


<210> 618
<211> 25
<212> PRT
<213> Homo sapiens

<400> 618
Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly Thr Glu Gly
 1               5                  10                  15      
Gln Pro Gln Ala Ile Glu Phe Arg Thr
            20                  25  


<210> 619
<211> 18
<212> PRT
<213> Homo sapiens

<400> 619
Arg His Asp Tyr Ile Leu Leu Pro Glu Asp Ala Leu Thr Asn Thr Thr
 1               5                  10                  15      
Arg Leu
        


<210> 620
<211> 30
<212> PRT
<213> Homo sapiens

<400> 620
Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu
 1               5                  10                  15      
Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp
            20                  25                  30  


<210> 621
<211> 23
<212> PRT
<213> Homo sapiens

<400> 621
Met Gly Asn Ser Ser Glu Phe Gln Lys Ala Val Lys Leu Val Ile Asn
 1               5                  10                  15      
Thr Val Ser Phe Asp Lys Asp
            20              


<210> 622
<211> 23
<212> PRT
<213> Homo sapiens

<400> 622
Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His
 1               5                  10                  15      
Asp Leu Val Leu Ile Arg Leu
            20              


<210> 623
<211> 22
<212> PRT
<213> Homo sapiens

<400> 623
Lys Val Pro Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro
 1               5                  10                  15      
Glu Trp Glu Gly Arg Ala
            20          


<210> 624
<211> 22
<212> PRT
<213> Homo sapiens

<400> 624
Lys Val Leu Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr
 1               5                  10                  15      
Val Cys Tyr Tyr Lys Tyr
            20          


<210> 625
<211> 23
<212> PRT
<213> Homo sapiens

<400> 625
Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly Ser Glu
 1               5                  10                  15      
His Ser Ile Asn Gly Arg Arg
            20              


<210> 626
<211> 17
<212> PRT
<213> Homo sapiens

<400> 626
Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn Phe Thr Ser His Arg
 1               5                  10                  15      
Leu
    


<210> 627
<211> 16
<212> PRT
<213> Homo sapiens

<400> 627
Lys Asn Glu Glu Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu
 1               5                  10                  15      


<210> 628
<211> 17
<212> PRT
<213> Homo sapiens

<400> 628
Lys Asn Ala Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg
 1               5                  10                  15      
Gln
    


<210> 629
<211> 16
<212> PRT
<213> Homo sapiens

<400> 629
Lys Leu Leu Asp Leu Ser Gly Asn Asn Leu Thr His Leu Pro Lys Gly
 1               5                  10                  15      


<210> 630
<211> 24
<212> PRT
<213> Homo sapiens

<400> 630
Lys Gly Cys Val Leu Leu Ser His Leu Asn Glu Thr Val Thr Val Ser
 1               5                  10                  15      
Ala Ser Leu Glu Ser Gly Arg Glu
            20                  


<210> 631
<211> 30
<212> PRT
<213> Homo sapiens

<400> 631
Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu Asn Glu Leu Gln Glu
 1               5                  10                  15      
Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln Ser Arg Val
            20                  25                  30  


<210> 632
<211> 19
<212> PRT
<213> Homo sapiens

<400> 632
Lys Cys Ile Arg Cys Ala Val Val Gly Asn Gly Gly Ile Leu Asn Gly
 1               5                  10                  15      
Ser Arg Gln
            


<210> 633
<211> 19
<212> PRT
<213> Homo sapiens

<400> 633
Lys Cys Ile Asn Gln Ser Ile Cys Glu Lys Cys Glu Asn Leu Thr Thr
 1               5                  10                  15      
Gly Lys His
            


<210> 634
<211> 11
<212> PRT
<213> Homo sapiens

<400> 634
Lys Cys Ile Asn Gln Ser Ile Cys Glu Lys Cys
 1               5                  10      


<210> 635
<211> 34
<212> PRT
<213> Homo sapiens

<400> 635
Lys Ala Val Val Asn Gly Asn Ile Met Trp Val Val Gly Gly Tyr Met
 1               5                  10                  15      
Phe Asn His Ser Asp Tyr Asn Met Val Leu Ala Tyr Asp Leu Ala Ser
            20                  25                  30          
Arg Glu
        


<210> 636
<211> 13
<212> PRT
<213> Homo sapiens

<400> 636
Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu
 1               5                  10              


<210> 637
<211> 19
<212> PRT
<213> Homo sapiens

<400> 637
Asn Ile Val Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu
 1               5                  10                  15      
Ala Lys Val
            


<210> 638
<211> 27
<212> PRT
<213> Homo sapiens

<400> 638
Met Thr Tyr Leu Tyr Glu Asp Ser Asn Val Trp His Asp Ile Ser Asp
 1               5                  10                  15      
Phe Leu Val Tyr Asn Lys Ser Arg Pro Ser Asn
            20                  25          


<210> 639
<211> 10
<212> PRT
<213> Homo sapiens

<400> 639
Arg Tyr Phe Tyr Asn Asn Gln Thr Lys Gln
 1               5                  10  


<210> 640
<211> 25
<212> PRT
<213> Homo sapiens

<400> 640
Arg Val Thr Trp Lys Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu
 1               5                  10                  15      
Thr Val Thr Asn His Thr Leu Arg Val
            20                  25  


<210> 641
<211> 13
<212> PRT
<213> Homo sapiens

<400> 641
Arg Val Asn Ser Thr Glu Leu Phe His Val Asp Arg His
 1               5                  10              


<210> 642
<211> 11
<212> PRT
<213> Homo sapiens

<400> 642
Arg Val Phe Pro Gln Val Asn Val Thr Lys Met
 1               5                  10      


<210> 643
<211> 19
<212> PRT
<213> Homo sapiens

<400> 643
Arg Thr Val Tyr Leu Tyr Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu
 1               5                  10                  15      
Ser Arg His
            


<210> 644
<211> 13
<212> PRT
<213> Homo sapiens

<400> 644
Arg Ser Val Asn Ile Leu Phe Asn Leu Thr His Arg Val
 1               5                  10              


<210> 645
<211> 21
<212> PRT
<213> Homo sapiens

<400> 645
Arg Ser Gly Gln Val Glu Val Asn Ile Thr Ala Phe Cys Gln Leu Ile
 1               5                  10                  15      
Tyr Pro Gly Lys Gly
            20      


<210> 646
<211> 17
<212> PRT
<213> Homo sapiens

<400> 646
Arg Arg Arg Asn Ile Thr Val Gly Leu Ala Val Phe Ala Thr Gly Arg
 1               5                  10                  15      
Phe
    


<210> 647
<211> 10
<212> PRT
<213> Homo sapiens

<400> 647
Arg Asn Gly Thr Leu Val Ala Phe Arg Gly
 1               5                  10  


<210> 648
<211> 24
<212> PRT
<213> Homo sapiens

<400> 648
Arg Ile Val Glu Ser Tyr Phe Met Leu Asn Ser Thr Leu Tyr Phe Ser
 1               5                  10                  15      
Tyr Thr His Met Val Cys Arg Thr
            20                  


<210> 649
<211> 25
<212> PRT
<213> Homo sapiens

<400> 649
Arg Gly Leu Arg Gly Pro Asn Leu Thr Ser Pro Ala Ser Ile Thr Phe
 1               5                  10                  15      
Thr Thr Gly Leu Glu Ala Pro Arg Asp
            20                  25  


<210> 650
<211> 16
<212> PRT
<213> Homo sapiens

<400> 650
Arg Ala Val Gln Pro His Asn Gly Cys Phe Asn Trp Thr Ser Arg Ala
 1               5                  10                  15      


<210> 651
<211> 16
<212> PRT
<213> Homo sapiens

<400> 651
Arg Ala Leu Leu Thr Asn Val Ser Ser Val Ala Leu Gly Ser Arg Arg
 1               5                  10                  15      


<210> 652
<211> 29
<212> PRT
<213> Homo sapiens

<400> 652
Met Lys Lys Asp Ala Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp
 1               5                  10                  15      
Leu Leu Lys Glu Leu Leu Glu Thr Gly Asp Asn Arg Glu
            20                  25                  


<210> 653
<211> 28
<212> PRT
<213> Homo sapiens

<400> 653
Lys Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu Ser
 1               5                  10                  15      
Leu Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn
            20                  25              


<210> 654
<211> 34
<212> PRT
<213> Homo sapiens

<400> 654
Lys Thr Val Ser Asn Leu Thr Glu Ser Ser Ser Glu Ser Ile Gln Ser
 1               5                  10                  15      
Phe Leu Gln Ser Met Ile Thr Ala Val Gly Ile Pro Glu Val Met Ser
            20                  25                  30          
Arg Leu
        


<210> 655
<211> 12
<212> PRT
<213> Homo sapiens

<400> 655
Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp
 1               5                  10          


<210> 656
<211> 32
<212> PRT
<213> Homo sapiens

<400> 656
Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile Ser
 1               5                  10                  15      
Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg Leu
            20                  25                  30          


<210> 657
<211> 13
<212> PRT
<213> Homo sapiens

<400> 657
Lys Gly Val Val Val Asn Ser Ser Val Met Val Lys Phe
 1               5                  10              


<210> 658
<211> 20
<212> PRT
<213> Homo sapiens

<400> 658
Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr Asp Phe
 1               5                  10                  15      
Gly Glu Lys Val
            20  


<210> 659
<211> 29
<212> PRT
<213> Homo sapiens

<400> 659
Lys Glu Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly
 1               5                  10                  15      
Glu Lys Leu Phe His Gly Val Ser Met Ser Glu Arg Cys
            20                  25                  


<210> 660
<211> 11
<212> PRT
<213> Homo sapiens

<400> 660
Ile Arg Val Gly Asn Ala Thr Ile Asp Arg Glu
 1               5                  10      


<210> 661
<211> 14
<212> PRT
<213> Homo sapiens

<400> 661
Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe Arg Ile
 1               5                  10                  


<210> 662
<211> 21
<212> PRT
<213> Homo sapiens

<400> 662
Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu
 1               5                  10                  15      
Ser Asn Ile Arg Tyr
            20      


<210> 663
<211> 29
<212> PRT
<213> Homo sapiens

<400> 663
Arg Asn Leu Asp Pro Glu Asn Gly Ser Gly Met Ala Leu Gln Pro Leu
 1               5                  10                  15      
Gln Ala Ala Pro Glu Pro Gly Ala Gln Gly Gln Arg Glu
            20                  25                  


<210> 664
<211> 19
<212> PRT
<213> Homo sapiens

<400> 664
Arg Ile Asp Asp Leu Gln Met Val Leu Asn Gln Thr Glu Asp His Arg
 1               5                  10                  15      
Gln Arg Val
            


<210> 665
<211> 12
<212> PRT
<213> Homo sapiens

<400> 665
Arg Gly His Asn Leu Ser Arg Asp Glu Leu Arg Gly
 1               5                  10          


<210> 666
<211> 30
<212> PRT
<213> Homo sapiens

<400> 666
Arg Asp Asn Leu Ser Gly Leu Ser Ala Asp Met Gln Asp Tyr Gly Leu
 1               5                  10                  15      
Ile Ile Asp Gly Ala Ala Leu Ser Leu Ile Met Lys Pro Arg
            20                  25                  30  


<210> 667
<211> 20
<212> PRT
<213> Homo sapiens

<400> 667
Gln Thr Val Gln Arg Ser Met Ala Asn Leu Ser Val Leu Phe Gly Gln
 1               5                  10                  15      
Val Val Arg Gly
            20  


<210> 668
<211> 20
<212> PRT
<213> Homo sapiens

<400> 668
Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn Met Asn Ile Ser Asn
 1               5                  10                  15      
Lys Ile Arg Asn
            20  


<210> 669
<211> 17
<212> PRT
<213> Homo sapiens

<400> 669
Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala Asp Asn Asn Thr Lys
 1               5                  10                  15      
Ala
    


<210> 670
<211> 12
<212> PRT
<213> Homo sapiens

<400> 670
Met Ile Gln Asn Thr Phe Asn Phe Ser Leu Lys Gln
 1               5                  10          


<210> 671
<211> 18
<212> PRT
<213> Homo sapiens

<400> 671
Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val
 1               5                  10                  15      
Arg Leu
        


<210> 672
<211> 21
<212> PRT
<213> Homo sapiens

<400> 672
Lys Val Leu Gln Gln Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His
 1               5                  10                  15      
Ser Val Glu Arg Phe
            20      


<210> 673
<211> 18
<212> PRT
<213> Homo sapiens

<400> 673
Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr
 1               5                  10                  15      
Arg Ala
        


<210> 674
<211> 21
<212> PRT
<213> Homo sapiens

<400> 674
Lys Leu Ala Val Asp Glu Glu Glu Asn Ala Asp Asn Asn Thr Lys Ala
 1               5                  10                  15      
Asn Val Thr Lys Pro
            20      


<210> 675
<211> 30
<212> PRT
<213> Homo sapiens

<400> 675
Lys Glu Lys Asp Ser Asn Ser Ser Ser Gly Ser Phe Asn Gly Glu Gln
 1               5                  10                  15      
Glu Pro Ile Ile Gly Phe Gln Pro Met Asp Ser Thr Arg Ala
            20                  25                  30  


<210> 676
<211> 17
<212> PRT
<213> Homo sapiens

<400> 676
Lys Ala Ser Gly Gln Val Ile Asp Glu Ile Ala Gly Asn Phe Ser Arg
 1               5                  10                  15      
Ala
    


<210> 677
<211> 14
<212> PRT
<213> Homo sapiens

<400> 677
Glu Asp Asp Phe Gln His Ser Ser Asn Ser Thr Tyr Arg Thr
 1               5                  10                  


<210> 678
<211> 10
<212> PRT
<213> Homo sapiens

<400> 678
Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln
 1               5                  10  


<210> 679
<211> 30
<212> PRT
<213> Homo sapiens

<400> 679
Lys Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln
 1               5                  10                  15      
Glu Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys
            20                  25                  30  


<210> 680
<211> 17
<212> PRT
<213> Homo sapiens

<400> 680
Lys Leu Asn Asp Thr Thr Leu Gln Val Leu Asn Thr Trp Tyr Thr Lys
 1               5                  10                  15      
Gln
    


<210> 681
<211> 18
<212> PRT
<213> Homo sapiens

<400> 681
Arg Tyr Leu Pro Val Asn Ser Ser Leu Leu Thr Ser Asp Cys Ser Glu
 1               5                  10                  15      
Arg Cys
        


<210> 682
<211> 29
<212> PRT
<213> Homo sapiens

<400> 682
Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser
 1               5                  10                  15      
Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp
            20                  25                  


<210> 683
<211> 14
<212> PRT
<213> Homo sapiens

<400> 683
Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn Thr Ser Asp
 1               5                  10                  


<210> 684
<211> 17
<212> PRT
<213> Homo sapiens

<400> 684
Lys Ser Ser Ile Ser Asn Asn Tyr Leu Asn Leu Thr Phe Pro Arg Lys
 1               5                  10                  15      
Arg
    


<210> 685
<211> 19
<212> PRT
<213> Homo sapiens

<400> 685
Lys Leu Leu Asp Met Leu Gln Tyr Tyr Leu Asn Leu Thr Glu Ala Asn
 1               5                  10                  15      
Leu Lys Gly
            


<210> 686
<211> 11
<212> PRT
<213> Homo sapiens

<400> 686
Lys Val Ile Asn Glu Thr Trp Ala Trp Lys Asn
 1               5                  10      


<210> 687
<211> 20
<212> PRT
<213> Homo sapiens

<400> 687
Arg His Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala
 1               5                  10                  15      
Glu Leu Arg Arg
            20  


<210> 688
<211> 12
<212> PRT
<213> Homo sapiens

<400> 688
Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala
 1               5                  10          


<210> 689
<211> 27
<212> PRT
<213> Homo sapiens

<400> 689
Arg Met Ala Thr Pro Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu
 1               5                  10                  15      
Pro Gln Gly Pro Met Gln Asn Ala Thr Lys Tyr
            20                  25          


<210> 690
<211> 16
<212> PRT
<213> Homo sapiens

<400> 690
Arg Cys Asn Thr Thr Gln Gly Asn Glu Val Thr Ser Ile Leu Arg Trp
 1               5                  10                  15      


<210> 691
<211> 27
<212> PRT
<213> Homo sapiens

<400> 691
Arg Met Ser Gly Asp Leu Ser Ser Asn Val Thr Val Ser Val Thr Ser
 1               5                  10                  15      
Ser Thr Ile Ser Ser Asn Val Ala Ser Lys Ala
            20                  25          


<210> 692
<211> 29
<212> PRT
<213> Homo sapiens

<400> 692
Ser Arg Met Ser Gly Glu Cys Ala Pro Asn Val Ser Val Ser Val Ser
 1               5                  10                  15      
Thr Ser His Thr Thr Ile Ser Gly Gly Gly Ser Arg Gly
            20                  25                  


<210> 693
<211> 14
<212> PRT
<213> Homo sapiens

<400> 693
Lys Ala Phe Arg Asn His Ser Phe Leu Leu Ile His Gln Arg
 1               5                  10                  


<210> 694
<211> 31
<212> PRT
<213> Homo sapiens

<400> 694
Arg Cys Gly Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys
 1               5                  10                  15      
Thr Asp Val Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val
            20                  25                  30      


<210> 695
<211> 24
<212> PRT
<213> Homo sapiens

<400> 695
Met Pro Asn Asn Leu Thr Asp Cys Glu Asp Gly Asp Gly Gly Ala Asn
 1               5                  10                  15      
Pro Gly Asp Gly Asn Pro Lys Glu
            20                  


<210> 696
<211> 18
<212> PRT
<213> Homo sapiens

<400> 696
Ala Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala
 1               5                  10                  15      
Arg Gly
        


<210> 697
<211> 24
<212> PRT
<213> Homo sapiens

<400> 697
Arg Val Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser
 1               5                  10                  15      
Tyr Pro Asn Asn Leu Leu Arg Asn
            20                  


<210> 698
<211> 21
<212> PRT
<213> Homo sapiens

<400> 698
Lys Phe Leu Thr Glu Val Glu Lys Asn Ala Thr Ala Leu Tyr His Val
 1               5                  10                  15      
Glu Ala Phe Lys Thr
            20      


<210> 699
<211> 27
<212> PRT
<213> Homo sapiens

<400> 699
Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu Thr Leu Asp Asn Asn
 1               5                  10                  15      
Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr
            20                  25          


<210> 700
<211> 12
<212> PRT
<213> Homo sapiens

<400> 700
Ile Pro Ala Ala Asn Leu Ser Ala Asn Arg Lys Arg
 1               5                  10          


<210> 701
<211> 26
<212> PRT
<213> Homo sapiens

<400> 701
Arg Ser Leu Asp Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu
 1               5                  10                  15      
Asn His Thr Glu Val Gln Phe Gln Lys Glu
            20                  25      


<210> 702
<211> 16
<212> PRT
<213> Homo sapiens

<400> 702
Arg Ser Ile Asn Val Thr Gly Gln Gly Phe Ser Leu Ile Gln Arg Phe
 1               5                  10                  15      


<210> 703
<211> 20
<212> PRT
<213> Homo sapiens

<400> 703
Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln Leu Leu Asp
 1               5                  10                  15      
Phe Glu Arg Ser
            20  


<210> 704
<211> 20
<212> PRT
<213> Homo sapiens

<400> 704
Lys Asn Phe Ser Ser Leu His Thr Val Phe Cys Ala Thr Gly Gly Gly
 1               5                  10                  15      
Ala Tyr Lys Phe
            20  


<210> 705
<211> 12
<212> PRT
<213> Homo sapiens

<400> 705
Lys Gly Asn Lys Asn Gly Asp Asn Asn Ser Asn His
 1               5                  10          


<210> 706
<211> 20
<212> PRT
<213> Homo sapiens

<400> 706
Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln Leu Leu Asp
 1               5                  10                  15      
Phe Glu Arg Thr
            20  


<210> 707
<211> 16
<212> PRT
<213> Homo sapiens

<400> 707
Arg Arg Gln Ala Pro Ile Asn Phe Thr Ser Arg Leu Asn Arg Arg Ala
 1               5                  10                  15      


<210> 708
<211> 25
<212> PRT
<213> Homo sapiens

<400> 708
Arg Gln Asn Ala Ser Ser Ser Ser Gln Gln Asn Asn Gly Pro Met Asp
 1               5                  10                  15      
Val Ile Ser Pro His Ser Tyr Lys Ser
            20                  25  


<210> 709
<211> 25
<212> PRT
<213> Homo sapiens

<400> 709
Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala Leu
 1               5                  10                  15      
His Val Ala Val Met Arg Asn Arg Phe
            20                  25  


<210> 710
<211> 20
<212> PRT
<213> Homo sapiens

<400> 710
Lys Thr Ile Ala Gln Gly Asn Leu Ser Asn Thr Asp Val Gln Ala Ala
 1               5                  10                  15      
Lys Asn Lys Leu
            20  


<210> 711
<211> 17
<212> PRT
<213> Homo sapiens

<400> 711
Lys Ser Thr Arg Met Ile Leu Asn Leu Thr Gln Ser Ser Gly Phe Asn
 1               5                  10                  15      
Gly
    


<210> 712
<211> 25
<212> PRT
<213> Homo sapiens

<400> 712
Lys Ser Ser Glu Phe Ala Ser Ile Pro Ala Asn Ser Ser Arg Pro Leu
 1               5                  10                  15      
Ser Asn Ile Ser Lys Ser Gly Arg Met
            20                  25  


<210> 713
<211> 28
<212> PRT
<213> Homo sapiens

<400> 713
Lys Arg Ala Met Asn Lys Ser Phe Met Glu Ser Gly Gly Thr Val Leu
 1               5                  10                  15      
Ser Thr Asn Trp Ser Asp Val Gly Lys Arg Lys Val
            20                  25              


<210> 714
<211> 24
<212> PRT
<213> Homo sapiens

<400> 714
Lys Asn Ala Ser Met Asn Thr Gln His Gly Thr Ala Thr Glu Val Ala
 1               5                  10                  15      
Val Glu Thr Thr Thr Pro Lys Gln
            20                  


<210> 715
<211> 17
<212> PRT
<213> Homo sapiens

<400> 715
Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr Ala Met Leu Arg
 1               5                  10                  15      
Lys
    


<210> 716
<211> 23
<212> PRT
<213> Homo sapiens

<400> 716
Gly Thr Ala Gly Val Tyr Gln Thr Gln Gly Leu Val Gly Ser Ser Asn
 1               5                  10                  15      
Gly Ser Ser His Lys Lys Ser
            20              


<210> 717
<211> 19
<212> PRT
<213> Homo sapiens

<400> 717
Gly Asp Val Asn Leu Thr Asn Leu Asn Leu Asp Asp Ile Val His Ile
 1               5                  10                  15      
Arg Arg Lys
            


<210> 718
<211> 32
<212> PRT
<213> Homo sapiens

<400> 718
Asn Asn Phe Ser Thr Glu Ile Asn Thr Thr Ser Ile Leu Val Gly Pro
 1               5                  10                  15      
Leu Val Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Arg Val
            20                  25                  30          


<210> 719
<211> 20
<212> PRT
<213> Homo sapiens

<400> 719
Lys Thr Gly Gly Asp Asn Lys Thr Leu Leu His Leu Gly Ser Ser Ala
 1               5                  10                  15      
Pro Gly Lys Glu
            20  


<210> 720
<211> 10
<212> PRT
<213> Homo sapiens

<400> 720
Met Ile Ser Asn Met Asn Ala Ser Arg Ala
 1               5                  10  


<210> 721
<211> 24
<212> PRT
<213> Homo sapiens

<400> 721
Lys His Tyr Leu Val Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys
 1               5                  10                  15      
His Phe Thr Cys Ser Gly Lys Gln
            20                  


<210> 722
<211> 23
<212> PRT
<213> Homo sapiens

<400> 722
Lys Asn Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu
 1               5                  10                  15      
Gln Ile Asp Asn Ala Arg Leu
            20              


<210> 723
<211> 46
<212> PRT
<213> Homo sapiens

<400> 723
Arg Phe Gly Gly Phe Gly Gly Pro Gly Gly Val Gly Gly Leu Gly Gly
 1               5                  10                  15      
Pro Gly Gly Phe Gly Pro Gly Gly Tyr Pro Gly Gly Ile His Glu Val
            20                  25                  30          
Ser Val Asn Gln Ser Leu Leu Gln Pro Leu Asn Val Lys Val
        35                  40                  45      


<210> 724
<211> 17
<212> PRT
<213> Homo sapiens

<400> 724
Lys Leu Asn Ser Ser Ser Ser Ser Ser Ser Asn Ser Ser Asn Glu Arg
 1               5                  10                  15      
Glu
    


<210> 725
<211> 19
<212> PRT
<213> Homo sapiens

<400> 725
Arg Lys Ser Ile Asp Glu Met Asn Asn Ala Trp Glu Asn Leu Asn Lys
 1               5                  10                  15      
Thr Trp Lys
            


<210> 726
<211> 21
<212> PRT
<213> Homo sapiens

<400> 726
Arg Arg Ser Leu Asn Ser Ser Ser Ser Ser Pro Pro Ser Ser Pro Thr
 1               5                  10                  15      
Met Met Pro Arg Leu
            20      


<210> 727
<211> 39
<212> PRT
<213> Homo sapiens

<400> 727
Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly Gly Gly Gly
 1               5                  10                  15      
Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu Phe Gly Phe
            20                  25                  30          
Met Gly Asn Gln Ser Arg Ser
        35                  


<210> 728
<211> 26
<212> PRT
<213> Homo sapiens

<400> 728
Arg Asn Thr Phe Thr Pro Gly Glu Lys Val Val Phe Thr Thr Glu Ile
 1               5                  10                  15      
Asn Asn Gln Thr Ser Lys Cys Ile Lys Thr
            20                  25      


<210> 729
<211> 31
<212> PRT
<213> Homo sapiens

<400> 729
Arg Glu Lys Thr Ser Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln
 1               5                  10                  15      
Leu Ile Glu Leu Thr Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe
            20                  25                  30      


<210> 730
<211> 22
<212> PRT
<213> Homo sapiens

<400> 730
Arg Glu Phe Val Met Gln Val Lys Val Gly Asn His Thr Ala Glu Gly
 1               5                  10                  15      
Thr Gly Thr Asn Lys Lys
            20          


<210> 731
<211> 17
<212> PRT
<213> Homo sapiens

<400> 731
Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg
 1               5                  10                  15      
Ala
    


<210> 732
<211> 15
<212> PRT
<213> Homo sapiens

<400> 732
Leu Lys Phe Leu Met Ser Asn Glu Thr Val Leu Leu Ala Lys His
 1               5                  10                  15  


<210> 733
<211> 29
<212> PRT
<213> Homo sapiens

<400> 733
Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His Ala Gly
 1               5                  10                  15      
Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His
            20                  25                  


<210> 734
<211> 21
<212> PRT
<213> Homo sapiens

<400> 734
Thr Ala Thr His Pro Pro Gly Pro Ala Val Gln Leu Asn Lys Thr Pro
 1               5                  10                  15      
Ser Ser Ser Lys Lys
            20      


<210> 735
<211> 22
<212> PRT
<213> Homo sapiens

<400> 735
Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu
 1               5                  10                  15      
Gly Glu Gln Asn Arg Thr
            20          


<210> 736
<211> 26
<212> PRT
<213> Homo sapiens

<400> 736
Ser Ala Met Ile Asn Ser Asn Asp Asp Asn Gly Val Leu Ala Gly Asn
 1               5                  10                  15      
Trp Ser Gly Thr Tyr Thr Gly Gly Arg Asp
            20                  25      


<210> 737
<211> 18
<212> PRT
<213> Homo sapiens

<400> 737
Arg Tyr Met Leu Met Leu Ser Phe Asn Asn Ser Leu Asp Val Ala Ala
 1               5                  10                  15      
His Leu
        


<210> 738
<211> 20
<212> PRT
<213> Homo sapiens

<400> 738
Arg Tyr Ile Arg Thr Leu Met Ser Ser Gly Gln Met Ala Pro Ser Ser
 1               5                  10                  15      
Ser Asn Lys Ser
            20  


<210> 739
<211> 22
<212> PRT
<213> Homo sapiens

<400> 739
Arg Val Val Ser Asn Ser Ser Val Leu Ala Ser Gln Ser Val Gly Ile
 1               5                  10                  15      
Thr Asn Val Arg Thr Val
            20          


<210> 740
<211> 27
<212> PRT
<213> Homo sapiens

<400> 740
Arg Val Leu Thr Asn Met Thr His Glu Asp Asp Val Pro Ile Asn Cys
 1               5                  10                  15      
Thr Met Val Leu Leu His Ile Val Ser Lys Cys
            20                  25          


<210> 741
<211> 20
<212> PRT
<213> Homo sapiens

<400> 741
Arg Val Leu Asn Ala Ser Thr Leu Ala Leu Ala Leu Ala Asn Leu Asn
 1               5                  10                  15      
Gly Ser Arg Gln
            20  


<210> 742
<211> 24
<212> PRT
<213> Homo sapiens

<400> 742
Arg Val Lys Ala Ile Ser Asp Ser Asp Gly Val Ser Tyr Pro Trp Tyr
 1               5                  10                  15      
Gly Asn Thr Thr Glu Thr Val Thr
            20                  


<210> 743
<211> 22
<212> PRT
<213> Homo sapiens

<400> 743
Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe Asn Glu Lys Asn
 1               5                  10                  15      
Met Asn Ile Thr Lys Asp
            20          


<210> 744
<211> 20
<212> PRT
<213> Homo sapiens

<400> 744
Arg Val Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser
 1               5                  10                  15      
Ser Ala Arg Ala
            20  


<210> 745
<211> 15
<212> PRT
<213> Homo sapiens

<400> 745
Arg Thr His Gly Arg Asn Gly Thr Glu Asn Ile Asn His Arg Gly
 1               5                  10                  15  


<210> 746
<211> 33
<212> PRT
<213> Homo sapiens

<400> 746
Arg Thr Ala Ala Asp Asn Phe Ser Thr Gln Tyr Val Leu Asp Gly Ser
 1               5                  10                  15      
Gly His Ile Leu Ser Gln Lys Pro Ser His Leu Gly Gln Gly Lys Lys
            20                  25                  30          
Val
    


<210> 747
<211> 17
<212> PRT
<213> Homo sapiens

<400> 747
Arg Ser Ser Ser Phe Gly Ser Val Ser Thr Ser Ser Asn Ser Ser Lys
 1               5                  10                  15      
Gly
    


<210> 748
<211> 19
<212> PRT
<213> Homo sapiens

<400> 748
Arg Ser Ser Ile Asn Ser Val Asp Gly Glu Ser Pro Asn Gly Ser Ser
 1               5                  10                  15      
Asp Arg Gly
            


<210> 749
<211> 24
<212> PRT
<213> Homo sapiens

<400> 749
Arg Ser Pro Pro Gly Glu Asn Pro Ser Pro Gln Gly Glu Leu Pro Ser
 1               5                  10                  15      
Pro Glu Ser Ser Arg Arg Leu Phe
            20                  


<210> 750
<211> 27
<212> PRT
<213> Homo sapiens

<400> 750
Arg Ser Gly Thr Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala
 1               5                  10                  15      
Asn Gly Thr Asp Ser Ile Met Ala Asn Arg Gly
            20                  25          


<210> 751
<211> 21
<212> PRT
<213> Homo sapiens

<400> 751
Arg Ser Cys Arg Ala Ala Gln Ala Met Asp Cys Glu Val Asn Asn Gly
 1               5                  10                  15      
Ser Ser Leu Arg Asp
            20      


<210> 752
<211> 39
<212> PRT
<213> Homo sapiens

<400> 752
Arg Arg Ser Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser
 1               5                  10                  15      
Gln Leu Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr
            20                  25                  30          
Ser Pro Gly Ser Leu Arg Lys
        35                  


<210> 753
<211> 32
<212> PRT
<213> Homo sapiens

<400> 753
Arg Arg Arg Asn Val Ser Gly Asn Asn Gly Pro Phe Gly Gln Asp Lys
 1               5                  10                  15      
Asn Ile Ala Met Thr Gly Gln Ile Thr Ser Thr Lys Pro Lys Arg Thr
            20                  25                  30          


<210> 754
<211> 10
<212> PRT
<213> Homo sapiens

<400> 754
Arg Arg Leu Ser Leu Asn Gln Ser Arg Gly
 1               5                  10  


<210> 755
<211> 23
<212> PRT
<213> Homo sapiens

<400> 755
Arg Arg Leu Ser Ile Gly Leu Asp Asn Gly Thr Ile Ser Glu Phe Ile
 1               5                  10                  15      
Leu Ser Glu Asp Tyr Asn Lys
            20              


<210> 756
<211> 28
<212> PRT
<213> Homo sapiens

<400> 756
Arg Arg Gly Ser Glu Val Ile Ser Asn Thr Thr Glu Asp Thr Gln Leu
 1               5                  10                  15      
Thr Ser Glu Thr Gln Ser Leu Thr Gly Asn Lys Lys
            20                  25              


<210> 757
<211> 19
<212> PRT
<213> Homo sapiens

<400> 757
Arg Arg Gly Ala Ser Val Asn Cys Thr Thr Arg Thr Asn Ser Thr Pro
 1               5                  10                  15      
Leu Arg Ala
            


<210> 758
<211> 26
<212> PRT
<213> Homo sapiens

<400> 758
Arg Arg Gly Ala Ile Lys His Gln Val Asn Phe Ser Ser Gly Gly Val
 1               5                  10                  15      
Ala Pro Leu Gly Gly Ser Trp His Arg Leu
            20                  25      


<210> 759
<211> 13
<212> PRT
<213> Homo sapiens

<400> 759
Arg Arg Glu Asn Asn Ser Pro Ser Asn Leu Pro Arg Pro
 1               5                  10              


<210> 760
<211> 16
<212> PRT
<213> Homo sapiens

<400> 760
Arg Gln Ser Ser Ser Glu Gln Cys Ser Asn Leu Ser Ser Val Arg Arg
 1               5                  10                  15      


<210> 761
<211> 24
<212> PRT
<213> Homo sapiens

<400> 761
Arg Gln Asn Ser Ser Ser Ala Gln Gly Ser Ser Ser Asn Ser Gly Gly
 1               5                  10                  15      
Gly Ser Gly Ile Pro Gln Pro Pro
            20                  


<210> 762
<211> 16
<212> PRT
<213> Homo sapiens

<400> 762
Arg Gln His Asn Val Ile Asn Leu Ser Ser Leu Asp Ala Met Met Asp
 1               5                  10                  15      


<210> 763
<211> 23
<212> PRT
<213> Homo sapiens

<400> 763
Arg Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn Leu Glu
 1               5                  10                  15      
Ala Pro Gly Asn Glu Arg Lys
            20              


<210> 764
<211> 35
<212> PRT
<213> Homo sapiens

<400> 764
Arg Asn Ile Tyr Gln Pro Pro Glu Gly Asn Ala Ser Val Ile Gln Asp
 1               5                  10                  15      
Phe Thr Glu Asp Gly His Leu Leu His Thr Phe Tyr Leu Gly Thr Gly
            20                  25                  30          
Arg Arg Val
        35  


<210> 765
<211> 23
<212> PRT
<213> Homo sapiens

<400> 765
Arg Asn Tyr Ser Lys Ser Thr Glu Leu Pro Gly Lys Asn Glu Ser Thr
 1               5                  10                  15      
Ile Glu Gln Ile Asp Lys Lys
            20              


<210> 766
<211> 12
<212> PRT
<213> Homo sapiens

<400> 766
Arg Asn Leu Thr Gly Val Met Asn Val Ala Arg Pro
 1               5                  10          


<210> 767
<211> 36
<212> PRT
<213> Homo sapiens

<400> 767
Arg Asn Lys Ser Ser Met Val Val Ile Asp Val Lys Met Leu Ser Gly
 1               5                  10                  15      
Phe Thr Pro Thr Met Ser Ser Ile Glu Glu Leu Glu Asn Lys Gly Gln
            20                  25                  30          
Val Met Lys Thr
        35      


<210> 768
<211> 27
<212> PRT
<213> Homo sapiens

<400> 768
Arg Asn Asp Ser Glu Ser Ser Gly Val Leu Tyr Ser Arg Ala Pro Thr
 1               5                  10                  15      
Tyr Phe Cys Gly Gln Thr Leu Thr Phe Arg Gln
            20                  25          


<210> 769
<211> 11
<212> PRT
<213> Homo sapiens

<400> 769
Arg Asn Ala Ser Leu Ser Gln Ser Pro Arg Val
 1               5                  10      


<210> 770
<211> 31
<212> PRT
<213> Homo sapiens

<400> 770
Arg Met Gln Asn Asn Ser Ser Pro Ser Ile Ser Pro Asn Thr Ser Phe
 1               5                  10                  15      
Thr Ser Asp Gly Ser Pro Ser Pro Leu Gly Gly Ile Lys Arg Lys
            20                  25                  30      


<210> 771
<211> 36
<212> PRT
<213> Homo sapiens

<400> 771
Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala Ser Pro
 1               5                  10                  15      
Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly Trp Ser
            20                  25                  30          
Gln Pro Lys Thr
        35      


<210> 772
<211> 20
<212> PRT
<213> Homo sapiens

<400> 772
Arg Met Glu Thr Val Ser Asn Ala Ser Ser Ser Ser Asn Pro Ser Ser
 1               5                  10                  15      
Pro Gly Arg Ile
            20  


<210> 773
<211> 29
<212> PRT
<213> Homo sapiens

<400> 773
Arg Met Asp Val Ser Ser Asn Ser Ser Pro Ser Cys Gln Ala Ser Pro
 1               5                  10                  15      
Ser Gln Glu Asp Val Ser Ala Asp Met Gln Glu Arg Arg
            20                  25                  


<210> 774
<211> 28
<212> PRT
<213> Homo sapiens

<400> 774
Arg Leu Gln Glu Met Gly Phe Ile Ile Tyr Gly Asn Glu Asn Ala Ser
 1               5                  10                  15      
Val Val Pro Leu Leu Leu Tyr Met Pro Gly Lys Val
            20                  25              


<210> 775
<211> 30
<212> PRT
<213> Homo sapiens

<400> 775
Arg Leu Pro Ile Asn Gly Ala Asn Thr Val Ile Gly Ser Asn Asn Ser
 1               5                  10                  15      
Val Gln Asn Val Pro Thr Pro Gln Thr Phe Gly Gly Lys His
            20                  25                  30  


<210> 776
<211> 22
<212> PRT
<213> Homo sapiens

<400> 776
Arg Leu Met Glu Glu Ile Met Ser Glu Lys Glu Asn Lys Thr Ile Val
 1               5                  10                  15      
Phe Val Glu Thr Lys Arg
            20          


<210> 777
<211> 12
<212> PRT
<213> Homo sapiens

<400> 777
Arg Leu Leu Pro Gly Asn Ala Thr Ile Ser Lys Ala
 1               5                  10          


<210> 778
<211> 28
<212> PRT
<213> Homo sapiens

<400> 778
Arg Leu Lys Asn Ile Ser Glu Asn Ala Asp Phe Phe Ala Ser Leu Gln
 1               5                  10                  15      
Leu Ser Glu Ser Ala Ala Arg Leu Arg Glu Met Ile
            20                  25              


<210> 779
<211> 19
<212> PRT
<213> Homo sapiens

<400> 779
Arg Lys Thr Glu Asn Ala Tyr Asn Ala Ile Ile Asn Gly Glu Ala Asn
 1               5                  10                  15      
Val Thr Gly
            


<210> 780
<211> 26
<212> PRT
<213> Homo sapiens

<400> 780
Arg Lys Met Phe Leu Phe Gly Thr Tyr Leu Thr Lys Asn Gly Ser Glu
 1               5                  10                  15      
Ile Pro Ser Thr Met Gln Asp Ala Lys Asp
            20                  25      


<210> 781
<211> 27
<212> PRT
<213> Homo sapiens

<400> 781
Arg Lys Lys Lys Ile Asn Gly Ser Ser Pro Asp Thr Ala Thr Ser Gly
 1               5                  10                  15      
Gly Tyr His Ser Pro Gly Asp Ser Ala Thr Gly
            20                  25          


<210> 782
<211> 25
<212> PRT
<213> Homo sapiens

<400> 782
Arg Lys Gly Ala Leu Glu Thr Asp Asn Ser Asn Ser Ser Ala Gln Val
 1               5                  10                  15      
Ser Thr Val Gly Gln Thr Ser Arg Glu
            20                  25  


<210> 783
<211> 12
<212> PRT
<213> Homo sapiens

<400> 783
Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly
 1               5                  10          


<210> 784
<211> 28
<212> PRT
<213> Homo sapiens

<400> 784
Arg Ile Val Ala Glu Cys Asn Ala Val Arg Gln Ala Leu Gln Asp Leu
 1               5                  10                  15      
Leu Ser Glu Tyr Met Asn Asn Thr Gly Arg Lys Glu
            20                  25              


<210> 785
<211> 24
<212> PRT
<213> Homo sapiens

<400> 785
Arg Phe Val Arg Leu Gly Thr Ala Ser Met Leu Thr Ser Pro Asp Gly
 1               5                  10                  15      
Pro Phe Ile Asn Leu Ser Arg Leu
            20                  


<210> 786
<211> 33
<212> PRT
<213> Homo sapiens

<400> 786
Arg Phe His Asn His Thr Thr His Met Ser Leu Val Gly Thr Phe Pro
 1               5                  10                  15      
Trp Met Ala Pro Glu Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys
            20                  25                  30          
Asp
    


<210> 787
<211> 18
<212> PRT
<213> Homo sapiens

<400> 787
Arg Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro
 1               5                  10                  15      
Arg Gly
        


<210> 788
<211> 19
<212> PRT
<213> Homo sapiens

<400> 788
Arg Glu Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val
 1               5                  10                  15      
Ser Arg Leu
            


<210> 789
<211> 13
<212> PRT
<213> Homo sapiens

<400> 789
Arg Glu Gly Val Gln Leu Asn Leu Ser Phe Ile Arg Pro
 1               5                  10              


<210> 790
<211> 19
<212> PRT
<213> Homo sapiens

<400> 790
Arg Asp Leu His Asn Met Gln Asn Gly Ser Thr Leu Val Cys Thr Leu
 1               5                  10                  15      
Thr Arg Glu
            


<210> 791
<211> 27
<212> PRT
<213> Homo sapiens

<400> 791
Arg Cys Tyr Val Asn Gly Gln Leu Val Ser Tyr Gly Asp Met Ala Trp
 1               5                  10                  15      
His Val Asn Thr Asn Asp Ser Tyr Asp Lys Cys
            20                  25          


<210> 792
<211> 24
<212> PRT
<213> Homo sapiens

<400> 792
Arg Cys Thr Cys Gly Phe Ser Ala Val Met Asn Arg Lys Phe Gly Asn
 1               5                  10                  15      
Asn Ser Gly Leu Phe Leu Glu Asp
            20                  


<210> 793
<211> 18
<212> PRT
<213> Homo sapiens

<400> 793
Arg Cys Asp Lys Asp Ser Met Pro Asp Gly Asn Leu Ser Glu Glu Glu
 1               5                  10                  15      
Lys Leu
        


<210> 794
<211> 19
<212> PRT
<213> Homo sapiens

<400> 794
Arg Ala Tyr Tyr Gly Asn Ile Asn Phe Phe Gly Gly Pro Ser Asn Thr
 1               5                  10                  15      
Ser Val Lys
            


<210> 795
<211> 12
<212> PRT
<213> Homo sapiens

<400> 795
Arg Ala Phe Ser Gln Asn Ala Asn Leu Thr Lys His
 1               5                  10          


<210> 796
<211> 13
<212> PRT
<213> Homo sapiens

<400> 796
Gln Asn Leu Ser Glu Pro Ile Arg Pro Asn Arg Arg Thr
 1               5                  10              


<210> 797
<211> 18
<212> PRT
<213> Homo sapiens

<400> 797
Pro Pro Thr Leu His Ala Thr Ala Ala Ser Val Ala Val Pro Asn Lys
 1               5                  10                  15      
Thr Cys
        


<210> 798
<211> 34
<212> PRT
<213> Homo sapiens

<400> 798
Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly Met
 1               5                  10                  15      
Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn
            20                  25                  30          
Arg Lys
        


<210> 799
<211> 28
<212> PRT
<213> Homo sapiens

<400> 799
Pro Phe Lys Tyr Ile Tyr Glu Leu Asn Asn Val Thr Pro Leu Asp Asn
 1               5                  10                  15      
Leu Leu Asn Leu Ser Asn Glu Ile Leu Asn Ala Ser
            20                  25              


<210> 800
<211> 33
<212> PRT
<213> Homo sapiens

<400> 800
Met Val Ile Ser Pro Ser Gly Phe Thr Ala Ser Pro Tyr Glu Gly Glu
 1               5                  10                  15      
Asn Ser Ser Asn Ile Ile Pro Gln Gln Met Ala Ala His Met Leu Arg
            20                  25                  30          
Ser
    


<210> 801
<211> 15
<212> PRT
<213> Homo sapiens

<400> 801
Met Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys Glu
 1               5                  10                  15  


<210> 802
<211> 10
<212> PRT
<213> Homo sapiens

<400> 802
Met Ser Asn Ile Thr Val Thr Tyr Arg Asp
 1               5                  10  


<210> 803
<211> 19
<212> PRT
<213> Homo sapiens

<400> 803
Met Ser Phe Asn Cys Ser Thr Arg Asn Cys Ser Ser Arg Pro Ile Gly
 1               5                  10                  15      
Gly Arg Cys
            


<210> 804
<211> 28
<212> PRT
<213> Homo sapiens

<400> 804
Met Arg Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser
 1               5                  10                  15      
Val Ser Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp
            20                  25              


<210> 805
<211> 13
<212> PRT
<213> Homo sapiens

<400> 805
Met Arg Lys Leu Gly His Leu Asn Asn Phe Thr Lys Leu
 1               5                  10              


<210> 806
<211> 25
<212> PRT
<213> Homo sapiens

<400> 806
Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr Asn Asn
 1               5                  10                  15      
Thr Ala Glu Glu Tyr Val Cys Arg Leu
            20                  25  


<210> 807
<211> 31
<212> PRT
<213> Homo sapiens

<400> 807
Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met Gln Ile Asn Met
 1               5                  10                  15      
Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys Arg Arg Gly
            20                  25                  30      


<210> 808
<211> 28
<212> PRT
<213> Homo sapiens

<400> 808
Met Met Arg Gly Gln Gly Leu Asn Met Thr Pro Ser Met Val Ala Pro
 1               5                  10                  15      
Ser Gly Met Pro Ala Thr Met Ser Asn Pro Arg Ile
            20                  25              


<210> 809
<211> 14
<212> PRT
<213> Homo sapiens

<400> 809
Met Leu Gln Asp Ile Gln Glu Val Leu Asn Arg Ser Lys Ser
 1               5                  10                  


<210> 810
<211> 14
<212> PRT
<213> Homo sapiens

<400> 810
Met Leu Phe Asn Val Glu Asn Gly Thr Pro Ala Ser Arg Glu
 1               5                  10                  


<210> 811
<211> 28
<212> PRT
<213> Homo sapiens

<400> 811
Met Leu Glu Pro Glu Gly Met Ser Pro Met Glu Pro Ala Gly Val Ser
 1               5                  10                  15      
Pro Met Pro Gly Thr Gln Asn Asp Thr Gly Arg Thr
            20                  25              


<210> 812
<211> 18
<212> PRT
<213> Homo sapiens

<400> 812
Met Ile Phe Glu Thr Thr Thr Lys Asn Glu Thr Ile Ala Gln Glu Asp
 1               5                  10                  15      
Lys Ile
        


<210> 813
<211> 18
<212> PRT
<213> Homo sapiens

<400> 813
Met Ile Phe Glu Asn Pro Ser Leu Cys Ala Ser Asn Ser Glu Pro Leu
 1               5                  10                  15      
Lys Leu
        


<210> 814
<211> 20
<212> PRT
<213> Homo sapiens

<400> 814
Met His Val Leu Thr Ala Pro Leu Leu Ala Asn Thr Thr Glu Asp Lys
 1               5                  10                  15      
Pro Ser Lys Asp
            20  


<210> 815
<211> 12
<212> PRT
<213> Homo sapiens

<400> 815
Met Glu Asn Asn Asn Leu Asp Glu Leu Asn Lys Ser
 1               5                  10          


<210> 816
<211> 18
<212> PRT
<213> Homo sapiens

<400> 816
Met Glu Asn Tyr Ser Ser Leu Val Ser Leu Glu Thr His Thr Gly Glu
 1               5                  10                  15      
Lys Leu
        


<210> 817
<211> 13
<212> PRT
<213> Homo sapiens

<400> 817
Met Cys Val Lys Asn Ser Thr Gly Val Glu Ile Lys Arg
 1               5                  10              


<210> 818
<211> 23
<212> PRT
<213> Homo sapiens

<400> 818
Met Ala Ser Tyr Leu Glu Thr Met Asn Ile Thr Leu Lys Gln Gln Leu
 1               5                  10                  15      
Val Lys Val Tyr Glu Lys Tyr
            20              


<210> 819
<211> 18
<212> PRT
<213> Homo sapiens

<400> 819
Met Ala Ser Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe
 1               5                  10                  15      
Lys Arg
        


<210> 820
<211> 29
<212> PRT
<213> Homo sapiens

<400> 820
Met Ala Ser Phe Leu Lys Asn Val Ser Ala Thr Val Ser Ile Asn Gly
 1               5                  10                  15      
Ser Gly Ile Ser Gly Asn Thr Ala Ile Asn Tyr Lys His
            20                  25                  


<210> 821
<211> 26
<212> PRT
<213> Homo sapiens

<400> 821
Met Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala
 1               5                  10                  15      
Asp Met Met Ser Pro Gly Glu Ser Lys Leu
            20                  25      


<210> 822
<211> 20
<212> PRT
<213> Homo sapiens

<400> 822
Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Cys Phe Ile Cys
 1               5                  10                  15      
Thr Ala Lys Thr
            20  


<210> 823
<211> 13
<212> PRT
<213> Homo sapiens

<400> 823
Leu Ser Gln Phe Ala Asp Asn Thr Thr Tyr Ala Lys Val
 1               5                  10              


<210> 824
<211> 14
<212> PRT
<213> Homo sapiens

<400> 824
Leu Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu Ala Lys Lys
 1               5                  10                  


<210> 825
<211> 19
<212> PRT
<213> Homo sapiens

<400> 825
Lys Tyr Ser Thr Thr Thr Ala Gln Asn Ser Ser Ser Ser Ser Ser Gln
 1               5                  10                  15      
Ser Lys Met
            


<210> 826
<211> 20
<212> PRT
<213> Homo sapiens

<400> 826
Lys Tyr Phe Glu Glu Gly Leu Gln Asp Gly Asn Asp Thr Phe Ala Leu
 1               5                  10                  15      
Leu Gly Lys Ala
            20  


<210> 827
<211> 28
<212> PRT
<213> Homo sapiens

<400> 827
Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser Leu Ser
 1               5                  10                  15      
Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu
            20                  25              


<210> 828
<211> 13
<212> PRT
<213> Homo sapiens

<400> 828
Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser
 1               5                  10              


<210> 829
<211> 16
<212> PRT
<213> Homo sapiens

<400> 829
Lys Val Asp Thr Asn Thr Glu Asn Ser Val Asn Thr Met Asn Arg Ser
 1               5                  10                  15      


<210> 830
<211> 13
<212> PRT
<213> Homo sapiens

<400> 830
Lys Val Asp Glu Phe Asn Val Ser Ser Pro Gln Phe Val
 1               5                  10              


<210> 831
<211> 21
<212> PRT
<213> Homo sapiens

<400> 831
Lys Val Ala Ile Gln Leu Asn Asp Thr His Pro Ser Leu Ala Ile Pro
 1               5                  10                  15      
Glu Leu Met Arg Ile
            20      


<210> 832
<211> 25
<212> PRT
<213> Homo sapiens

<400> 832
Lys Thr Leu Ile Pro Asn Ala Ser Asn Glu Ala Ile Gln Leu Met Thr
 1               5                  10                  15      
Glu Met Leu Asn Trp Asp Pro Lys Lys
            20                  25  


<210> 833
<211> 26
<212> PRT
<213> Homo sapiens

<400> 833
Lys Thr Gly Glu Asp Glu Asp Glu Glu Asp Asn Asp Ala Leu Leu Lys
 1               5                  10                  15      
Glu Asn Glu Ser Pro Asp Val Arg Arg Asp
            20                  25      


<210> 834
<211> 32
<212> PRT
<213> Homo sapiens

<400> 834
Lys Ser Ser Ser Gly Asn Glu Asn Asp Glu Gln Asp Ser Asp Asn Ala
 1               5                  10                  15      
Asn Met Ser Thr Gln Ser Pro Val Ser Ser Glu Glu Tyr Asp Arg Thr
            20                  25                  30          


<210> 835
<211> 38
<212> PRT
<213> Homo sapiens

<400> 835
Lys Ser Ser Lys Asp Gly Asn Ser Val Met Ser Pro Leu Phe Ile Ser
 1               5                  10                  15      
Thr Phe Thr Leu Asn Ile Ser His Thr Ala Ser Glu Gly Ala Thr Gly
            20                  25                  30          
Glu Asn Leu Ala Lys Val
        35              


<210> 836
<211> 23
<212> PRT
<213> Homo sapiens

<400> 836
Lys Ser Arg Met Ala Ile Trp Ala Ala Thr Asp His Asn Val Asp Asn
 1               5                  10                  15      
Thr Thr Glu Ile Phe Arg Glu
            20              


<210> 837
<211> 28
<212> PRT
<213> Homo sapiens

<400> 837
Lys Ser Gln Leu Gly Phe Leu Asn Val Thr Asn Tyr Cys His Leu Ala
 1               5                  10                  15      
His Glu Leu Arg Leu Ser Cys Met Glu Arg Lys Lys
            20                  25              


<210> 838
<211> 20
<212> PRT
<213> Homo sapiens

<400> 838
Lys Ser Ile Met Glu Asn Ala Ser Ala Gly Val Glu His Leu Leu Leu
 1               5                  10                  15      
Gly Asn Lys Cys
            20  


<210> 839
<211> 21
<212> PRT
<213> Homo sapiens

<400> 839
Lys Ser Phe Ser Leu Asn Arg Thr Leu Thr Val His Gln Arg Ile His
 1               5                  10                  15      
Thr Gly Glu Lys Pro
            20      


<210> 840
<211> 15
<212> PRT
<213> Homo sapiens

<400> 840
Lys Gln Pro Lys Val Gly Phe Tyr Ser Ser Leu Asn Gln Thr His
 1               5                  10                  15  


<210> 841
<211> 16
<212> PRT
<213> Homo sapiens

<400> 841
Lys Asn Trp Ile Ala Leu Ile Pro Lys Gly Asn Cys Thr Tyr Arg Asp
 1               5                  10                  15      


<210> 842
<211> 21
<212> PRT
<213> Homo sapiens

<400> 842
Lys Asn Arg Val Gln Ser Lys Ile Ser Asn Leu Thr Asp Ala Lys Asn
 1               5                  10                  15      
Pro Asn Leu Arg Lys
            20      


<210> 843
<211> 15
<212> PRT
<213> Homo sapiens

<400> 843
Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val Ser Gly Arg Val
 1               5                  10                  15  


<210> 844
<211> 15
<212> PRT
<213> Homo sapiens

<400> 844
Lys Asn Leu Asn Leu Glu Leu Asn Pro Asn Gln Ser Val Lys Val
 1               5                  10                  15  


<210> 845
<211> 20
<212> PRT
<213> Homo sapiens

<400> 845
Lys Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn
 1               5                  10                  15      
Ile Ala Arg Gln
            20  


<210> 846
<211> 31
<212> PRT
<213> Homo sapiens

<400> 846
Lys Asn Glu Glu Ile Asp Glu Met Ile Lys Glu Ala Pro Gly Pro Ile
 1               5                  10                  15      
Asn Phe Thr Val Phe Leu Ser Met Phe Gly Glu Lys Leu Lys Gly
            20                  25                  30      


<210> 847
<211> 39
<212> PRT
<213> Homo sapiens

<400> 847
Lys Asn Asn Ser Pro Gly Thr Ala Glu Gly Cys Gly Gly Gly Gly Gly
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Gly
            20                  25                  30          
Gly Gly Gly Gly Asp Lys Ser
        35                  


<210> 848
<211> 29
<212> PRT
<213> Homo sapiens

<400> 848
Lys Asn Asn Ser Met Asn Ser Asn Met Gly Thr Gly Thr Phe Gly Pro
 1               5                  10                  15      
Val Gly Asn Gly Val His Thr Gly Pro Glu Ser Arg Glu
            20                  25                  


<210> 849
<211> 13
<212> PRT
<213> Homo sapiens

<400> 849
Lys Asn Leu Ser Ile Asn Asn Asp Leu Asn Leu Arg Tyr
 1               5                  10              


<210> 850
<211> 20
<212> PRT
<213> Homo sapiens

<400> 850
Lys Asn Ile Thr Asp Glu Leu Gly Val Leu Gly Val Ala Gly Pro Gln
 1               5                  10                  15      
Ala Arg Lys Val
            20  


<210> 851
<211> 19
<212> PRT
<213> Homo sapiens

<400> 851
Lys Met Ser Ala Thr Phe Ile Gly Asn Asn Thr Ala Ile Gln Glu Leu
 1               5                  10                  15      
Phe Lys Arg
            


<210> 852
<211> 20
<212> PRT
<213> Homo sapiens

<400> 852
Lys Met Asn Ser Ser Ile Met Ala Asn Val Thr Lys Ala Phe Val Gly
 1               5                  10                  15      
Asp Ser Lys Asp
            20  


<210> 853
<211> 16
<212> PRT
<213> Homo sapiens

<400> 853
Lys Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile
 1               5                  10                  15      


<210> 854
<211> 27
<212> PRT
<213> Homo sapiens

<400> 854
Lys Leu Tyr Asp Gln Cys His Asp Thr Leu Val Gln Phe Gly Gly Phe
 1               5                  10                  15      
Leu Ala Ser Asn Leu Ser Thr Glu Asp Tyr Ile
            20                  25          


<210> 855
<211> 20
<212> PRT
<213> Homo sapiens

<400> 855
Lys Leu Val Gly Leu Asn Leu Ser Pro Pro Met Ser Pro Val Gln Leu
 1               5                  10                  15      
Pro Leu Arg Ala
            20  


<210> 856
<211> 23
<212> PRT
<213> Homo sapiens

<400> 856
Lys Leu Ser Glu Leu His Asp Asn Gln Asp Gly Leu Val Asn Met Glu
 1               5                  10                  15      
Ser Leu Asn Ser Thr Arg Ser
            20              


<210> 857
<211> 20
<212> PRT
<213> Homo sapiens

<400> 857
Lys Leu Ser Asp Ser Asn Gln Thr Leu Lys Val Ile Gly Glu Phe Ile
 1               5                  10                  15      
Leu Glu Arg Asn
            20  


<210> 858
<211> 26
<212> PRT
<213> Homo sapiens

<400> 858
Lys Leu Met Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala
 1               5                  10                  15      
Gly Ala Gly Gly Gly Gly Met Phe Gly Ser
            20                  25      


<210> 859
<211> 24
<212> PRT
<213> Homo sapiens

<400> 859
Lys Leu Leu Met Glu Asn Pro Tyr Glu Gly Pro Asp Ser Gln Lys Glu
 1               5                  10                  15      
Lys Asp Ser Asn Ser Ser Lys Tyr
            20                  


<210> 860
<211> 27
<212> PRT
<213> Homo sapiens

<400> 860
Lys Leu Lys Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Ser
 1               5                  10                  15      
Gly Met Gln Asn Met Ser Ile His Thr Lys Thr
            20                  25          


<210> 861
<211> 19
<212> PRT
<213> Homo sapiens

<400> 861
Lys Leu Glu Thr Lys Phe Lys Ser Gly Leu Asn Gly Ser Ile Leu Ala
 1               5                  10                  15      
Glu Arg Glu
            


<210> 862
<211> 33
<212> PRT
<213> Homo sapiens

<400> 862
Lys Lys Val Asp Ala Gln Ser Ser Ala Gly Lys Glu Asp Met Leu Leu
 1               5                  10                  15      
Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn Ile Ser Ser Ser Pro Lys
            20                  25                  30          
Gly
    


<210> 863
<211> 24
<212> PRT
<213> Homo sapiens

<400> 863
Lys Lys Arg Gly Thr Phe Ile Glu Phe Arg Asn Gly Met Leu Asn Ile
 1               5                  10                  15      
Ser Pro Ile Gly Arg Ser Cys Thr
            20                  


<210> 864
<211> 22
<212> PRT
<213> Homo sapiens

<400> 864
Lys Lys Gln Ser Asn Asn Asp Leu Phe Gln Val Asn Ser Thr Ser Asp
 1               5                  10                  15      
Asp Glu Ile Pro Arg Lys
            20          


<210> 865
<211> 12
<212> PRT
<213> Homo sapiens

<400> 865
Lys Lys Gln Ile Asn Asp Ser Ala Asn Leu Arg Glu
 1               5                  10          


<210> 866
<211> 20
<212> PRT
<213> Homo sapiens

<400> 866
Lys Lys Asn Ile Thr Tyr Tyr Asp Ser Met Gly Gly Ile Asn Asn Glu
 1               5                  10                  15      
Ala Cys Arg Ile
            20  


<210> 867
<211> 29
<212> PRT
<213> Homo sapiens

<400> 867
Lys His Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Asp
 1               5                  10                  15      
Pro Ala Trp Thr Ser Ala Leu Ser Gly Asn Ser Ser Gly
            20                  25                  


<210> 868
<211> 11
<212> PRT
<213> Homo sapiens

<400> 868
Lys His Pro Leu Thr Ala Asn Ala Ser Arg Ser
 1               5                  10      


<210> 869
<211> 19
<212> PRT
<213> Homo sapiens

<400> 869
Lys Gly Arg Thr Phe Asn Leu Thr Ala Gly Asn Asp Asp Ser Ile Val
 1               5                  10                  15      
Met Lys Ala
            


<210> 870
<211> 19
<212> PRT
<213> Homo sapiens

<400> 870
Lys Gly Leu Gly Ala Gln Thr Gly Val Leu Arg Met Lys Gly Val Asn
 1               5                  10                  15      
Leu Ser Cys
            


<210> 871
<211> 18
<212> PRT
<213> Homo sapiens

<400> 871
Lys Gly Lys Arg Met Leu Ser Glu Tyr Leu Ser Pro Asn Leu Ser Leu
 1               5                  10                  15      
Arg Ala
        


<210> 872
<211> 39
<212> PRT
<213> Homo sapiens

<400> 872
Lys Gly His Pro Asn Arg Ser Ala Leu Ser Leu Pro Pro Gly Leu Arg
 1               5                  10                  15      
Ile Gly Pro Ser Gly Ile Pro Gln Ala Gly Leu Gly Val Trp Asn Glu
            20                  25                  30          
Ala Ser Asp Leu Pro Leu Gly
        35                  


<210> 873
<211> 33
<212> PRT
<213> Homo sapiens

<400> 873
Lys Gly Asp Ile Gly Ile Val Pro Leu Gly Leu Val Glu Thr Ala Ile
 1               5                  10                  15      
Leu Lys Pro Ser Met Trp Ser Thr Phe Ala Pro Val Asn Thr Thr Thr
            20                  25                  30          
Glu
    


<210> 874
<211> 19
<212> PRT
<213> Homo sapiens

<400> 874
Lys Gly Cys Arg Cys Asp Pro Gln Gly Val Asn Ala Thr Ala Thr Ala
 1               5                  10                  15      
Asp Arg Leu
            


<210> 875
<211> 16
<212> PRT
<213> Homo sapiens

<400> 875
Lys Phe Asn Val Ala Thr Gln Asn Val Ser Thr Leu Ser Ser Lys Val
 1               5                  10                  15      


<210> 876
<211> 23
<212> PRT
<213> Homo sapiens

<400> 876
Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu Thr Ile Ser Ala Ala
 1               5                  10                  15      
Arg Leu Tyr Tyr Tyr Arg Asp
            20              


<210> 877
<211> 22
<212> PRT
<213> Homo sapiens

<400> 877
Lys Phe Asp Val Asn Thr Ser Ala Val Gln Val Leu Ile Glu His Ile
 1               5                  10                  15      
Gly Asn Leu Asp Arg Ala
            20          


<210> 878
<211> 31
<212> PRT
<213> Homo sapiens

<400> 878
Lys Glu Arg Pro Ile Ser Met Ile Asn Glu Ala Ser Asn Tyr Asn Val
 1               5                  10                  15      
Thr Ser Asp Tyr Ala Val His Pro Met Ser Pro Val Gly Arg Thr
            20                  25                  30      


<210> 879
<211> 20
<212> PRT
<213> Homo sapiens

<400> 879
Lys Glu Asn Leu Pro Glu Asn Val Thr Ala Ser Glu Ser Asp Ala Glu
 1               5                  10                  15      
Val Glu Arg Ser
            20  


<210> 880
<211> 20
<212> PRT
<213> Homo sapiens

<400> 880
Lys Glu Asn Lys Gly Asp Asn Asn Cys Asn His Asn Asp Pro Leu Tyr
 1               5                  10                  15      
Glu Asn Ser Ser
            20  


<210> 881
<211> 12
<212> PRT
<213> Homo sapiens

<400> 881
Lys Glu Asn Pro Ser Thr Val Gly Val Glu Arg Val
 1               5                  10          


<210> 882
<211> 14
<212> PRT
<213> Homo sapiens

<400> 882
Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr Glu Glu Lys Ala
 1               5                  10                  


<210> 883
<211> 22
<212> PRT
<213> Homo sapiens

<400> 883
Lys Glu Ile Ala Phe Leu Ser Glu Lys Ile Ser Asn Leu Thr Ile Val
 1               5                  10                  15      
Gln Ala Glu Ile Lys Asp
            20          


<210> 884
<211> 22
<212> PRT
<213> Homo sapiens

<400> 884
Lys Asp Leu Tyr Arg Ser Asn Ile Ser Pro Leu Thr Ser Glu Lys Asp
 1               5                  10                  15      
Leu Asp Asp Phe Arg Arg
            20          


<210> 885
<211> 32
<212> PRT
<213> Homo sapiens

<400> 885
Lys Asp Leu Gln Arg Ser Leu Pro Pro Val Met Ala Gln Asn Leu Ser
 1               5                  10                  15      
Ile Pro Leu Ala Phe Ala Cys Leu Leu His Leu Ala Asn Glu Lys Asn
            20                  25                  30          


<210> 886
<211> 30
<212> PRT
<213> Homo sapiens

<400> 886
Lys Asp Gly Lys Asn Lys Thr Asp Lys Lys Asp His Ser Asn Ile Gly
 1               5                  10                  15      
Asn Asp Ser Lys Lys Thr Asp Gly Thr Lys Gln Arg Ser His
            20                  25                  30  


<210> 887
<211> 28
<212> PRT
<213> Homo sapiens

<400> 887
Lys Ala Val Val Val Phe Asp Glu Ala His Asn Ile Asp Asn Val Cys
 1               5                  10                  15      
Ile Asp Ser Met Ser Val Asn Leu Thr Arg Arg Thr
            20                  25              


<210> 888
<211> 17
<212> PRT
<213> Homo sapiens

<400> 888
Lys Ala Val Thr Val Met Met Asp Pro Asn Ser Thr Gln Arg Tyr Arg
 1               5                  10                  15      
Leu
    


<210> 889
<211> 25
<212> PRT
<213> Homo sapiens

<400> 889
Lys Ala Leu Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met
 1               5                  10                  15      
Val Glu Gln Asn Leu Met Glu Lys Leu
            20                  25  


<210> 890
<211> 24
<212> PRT
<213> Homo sapiens

<400> 890
Lys Ala Phe Ala Ala Asp Thr Gly Met Asn Arg Ser Gln Ser Glu Tyr
 1               5                  10                  15      
Cys Asn Val Gly Thr Lys Thr Tyr
            20                  


<210> 891
<211> 15
<212> PRT
<213> Homo sapiens

<400> 891
Gly Lys Val Phe Asn Asp Ser Gly Asn Leu Ser Asn His Lys Arg
 1               5                  10                  15  


<210> 892
<211> 19
<212> PRT
<213> Homo sapiens

<400> 892
Gly Phe Val Asn Ser Thr Met Glu Glu Ala Gly Leu Cys Gly Leu Arg
 1               5                  10                  15      
Glu Lys Ala
            


<210> 893
<211> 29
<212> PRT
<213> Homo sapiens

<400> 893
Gly Ala Glu Val Lys Phe Val Leu Lys His Gln Asn Val Ser Glu Phe
 1               5                  10                  15      
Ala Ser Ser Ser Gly Gly Ser Gln Leu Leu Phe Lys Gln
            20                  25                  


<210> 894
<211> 23
<212> PRT
<213> Homo sapiens

<400> 894
Phe Val Gln Asn Cys Thr Ser Leu Asn Ser Leu Asn Glu Val Ile Pro
 1               5                  10                  15      
Thr Asp Leu Gln Ser Lys Phe
            20              


<210> 895
<211> 20
<212> PRT
<213> Homo sapiens

<400> 895
Phe Gly Ser Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly
 1               5                  10                  15      
Asp Asn Lys Gln
            20  


<210> 896
<211> 24
<212> PRT
<213> Homo sapiens

<400> 896
Glu Gln Thr Tyr His Met Ala Leu Asn Ala Ala Thr Phe Pro Lys Asn
 1               5                  10                  15      
Ala Thr Trp Ile Gly Pro Leu Trp
            20                  


<210> 897
<211> 32
<212> PRT
<213> Homo sapiens

<400> 897
Glu Pro Cys Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu
 1               5                  10                  15      
Gly Ser Val Asp Gln Asn His Ser Trp Leu Gly Arg Lys Arg Arg Asn
            20                  25                  30          


<210> 898
<211> 25
<212> PRT
<213> Homo sapiens

<400> 898
Glu Glu Asn Thr Asp Asp Asn Ile Thr Val Gln Gly Glu Ile Arg Lys
 1               5                  10                  15      
Glu Asp Gly Met Glu Asn Leu Lys Asn
            20                  25  


<210> 899
<211> 18
<212> PRT
<213> Homo sapiens

<400> 899
Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser Gln Val Val Ala Glu Thr
 1               5                  10                  15      
Arg Lys
        


<210> 900
<211> 21
<212> PRT
<213> Homo sapiens

<400> 900
Asp Leu Gly Asn Val Pro Asn Gly Ser Ala Leu Thr Asp Gly Ser Gln
 1               5                  10                  15      
Leu Pro Ser Arg Asp
            20      


<210> 901
<211> 16
<212> PRT
<213> Homo sapiens

<400> 901
Ala Met Ala Tyr Asp Leu Leu Pro Ile Glu Asn Asp Thr Tyr Lys Gln
 1               5                  10                  15      


<210> 902
<211> 21
<212> PRT
<213> Homo sapiens

<400> 902
Ala Gly Leu Gly Asn Gly Val Leu Pro Asn Val Ser Glu Glu Thr Val
 1               5                  10                  15      
Ser Pro Thr Arg Ala
            20      


<210> 903
<211> 26
<212> PRT
<213> Homo sapiens

<400> 903
Ala Ala Glu Gly Gly Asn Thr Ser Asp Thr Gln Ser Ser Ser Ser Val
 1               5                  10                  15      
Asn Ile Val Met Gly Pro Ser Ala Arg Ala
            20                  25      


<210> 904
<211> 14
<212> PRT
<213> Homo sapiens

<400> 904
Met Asn Asn Thr Ala Ala Ser Pro Met Ser Thr Ala Thr Ser
 1               5                  10                  


<210> 905
<211> 27
<212> PRT
<213> Homo sapiens

<400> 905
Met Asp Ser Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu
 1               5                  10                  15      
Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Asn
            20                  25          


<210> 906
<211> 17
<212> PRT
<213> Homo sapiens

<400> 906
Met Ala Leu Asn Asn Val Ser Leu Ser Ser Gly Asp Gln Arg Ser Arg
 1               5                  10                  15      
Val
    


<210> 907
<211> 27
<212> PRT
<213> Homo sapiens

<400> 907
Met Ala Glu Ala Gly Ala Gly Leu Ser Glu Thr Val Thr Glu Thr Thr
 1               5                  10                  15      
Val Thr Val Thr Thr Glu Pro Glu Asn Arg Ser
            20                  25          


<210> 908
<211> 36
<212> PRT
<213> Homo sapiens

<400> 908
Val Tyr Asn Gly Ser Val Asp Glu Gly Ser Lys Pro Gly Thr Tyr Val
 1               5                  10                  15      
Met Thr Val Thr Ala Asn Asp Ala Asp Asp Ser Thr Thr Ala Asn Gly
            20                  25                  30          
Met Val Arg Tyr
        35      


<210> 909
<211> 23
<212> PRT
<213> Homo sapiens

<400> 909
Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp Ile Thr Phe
 1               5                  10                  15      
Thr Tyr Phe Gln Pro Lys Pro
            20              


<210> 910
<211> 26
<212> PRT
<213> Homo sapiens

<400> 910
Arg Val Ser Thr Val Tyr Ala Asn Asn Gly Ser Val Leu Gln Gly Thr
 1               5                  10                  15      
Ser Val Ala Ser Val Tyr His Gly Lys Ile
            20                  25      


<210> 911
<211> 16
<212> PRT
<213> Homo sapiens

<400> 911
Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys Tyr Arg Ala
 1               5                  10                  15      


<210> 912
<211> 25
<212> PRT
<213> Homo sapiens

<400> 912
Arg Gln Leu Cys Gly Leu Leu Leu Gly Gly Gly Gly Asn Arg Ser His
 1               5                  10                  15      
Ser Thr Pro Tyr Cys Gly Leu Arg Arg
            20                  25  


<210> 913
<211> 15
<212> PRT
<213> Homo sapiens

<400> 913
Arg Asn Ser Ser Ser Ser Gly Ser Ser Gly Ala Gly Gln Lys Arg
 1               5                  10                  15  


<210> 914
<211> 15
<212> PRT
<213> Homo sapiens

<400> 914
Arg Asn His Ser Cys Ser Glu Gly Gln Ile Ser Ile Phe Arg Tyr
 1               5                  10                  15  


<210> 915
<211> 34
<212> PRT
<213> Homo sapiens

<400> 915
Arg Gly Leu Asn Ile Ala Leu Val Asn Gly Thr Thr Gly Ala Val Leu
 1               5                  10                  15      
Gly Gln Lys Ala Phe Asp Met Tyr Ser Gly Asp Val Met His Leu Val
            20                  25                  30          
Lys Phe
        


<210> 916
<211> 17
<212> PRT
<213> Homo sapiens

<400> 916
Met Gly Ala Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn Gln Arg
 1               5                  10                  15      
Arg
    


<210> 917
<211> 18
<212> PRT
<213> Homo sapiens

<400> 917
Leu Phe Thr Met His Asn Asn Arg Ser Leu Thr Ile His Gln Ala Met
 1               5                  10                  15      
Arg Gly
        


<210> 918
<211> 23
<212> PRT
<213> Homo sapiens

<400> 918
Lys Val Met Val Val Leu Thr Asp Gly Gly Ile Phe Glu Asp Pro Leu
 1               5                  10                  15      
Asn Leu Thr Thr Val Ile Asn
            20              


<210> 919
<211> 23
<212> PRT
<213> Homo sapiens

<400> 919
Lys Arg Arg Lys Pro Gly Ser His Thr His Ser Ala Ser Glu Asp Asn
 1               5                  10                  15      
Thr Thr Asn Asn Val Arg Glu
            20              


<210> 920
<211> 26
<212> PRT
<213> Homo sapiens

<400> 920
Lys Asn Ala Ser Asp Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp
 1               5                  10                  15      
Gly Asp Glu Asp Leu Glu Thr Lys Lys Phe
            20                  25      


<210> 921
<211> 35
<212> PRT
<213> Homo sapiens

<400> 921
Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn Ser Ser Asp Ala Pro
 1               5                  10                  15      
Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly Arg Trp Val Ser Leu
            20                  25                  30          
His Arg Ser
        35  


<210> 922
<211> 22
<212> PRT
<213> Homo sapiens

<400> 922
Lys Met Leu Ala Gln Lys Ser Gly Asn Ile Ile Asn Met Ser Ser Val
 1               5                  10                  15      
Ala Ser Ser Val Lys Gly
            20          


<210> 923
<211> 27
<212> PRT
<213> Homo sapiens

<400> 923
Lys Gly Cys Val Leu Leu Ser His Leu Asn Glu Thr Val Thr Val Ser
 1               5                  10                  15      
Ala Ser Leu Glu Ser Gly Arg Glu Asn Arg Ser
            20                  25          


<210> 924
<211> 15
<212> PRT
<213> Homo sapiens

<400> 924
Lys Asp Asn Phe Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val
 1               5                  10                  15  


<210> 925
<211> 16
<212> PRT
<213> Homo sapiens

<400> 925
Lys Ala Ile His Leu Asp Leu Glu Glu Tyr Arg Asn Ser Ser Arg Val
 1               5                  10                  15      


<210> 926
<211> 24
<212> PRT
<213> Homo sapiens

<400> 926
Glu Asn Ala Pro Asn Gly Thr Leu Val Val Thr Val Asn Ala Thr Asp
 1               5                  10                  15      
Leu Asp Glu Gly Val Asn Lys Asp
            20                  


<210> 927
<211> 16
<212> PRT
<213> Homo sapiens

<400> 927
Ala Asn Arg Thr Gly Ser Val Glu Ala Gln Thr Ala Leu Lys Lys Arg
 1               5                  10                  15      


<210> 928
<211> 25
<212> PRT
<213> Homo sapiens

<400> 928
Arg Thr Ser Asn Gly Gln Pro Val Lys Thr Ala Gly Glu Ile Thr Gln
 1               5                  10                  15      
His Asn Val Thr Glu Leu Leu Arg Asp
            20                  25  


<210> 929
<211> 19
<212> PRT
<213> Homo sapiens

<400> 929
Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Pro
 1               5                  10                  15      
Met Leu Leu
            


<210> 930
<211> 28
<212> PRT
<213> Homo sapiens

<400> 930
Met Arg Asp Ser Glu Ala Thr Gly Ser Ala Ser Ser Ala Gln Asp Ser
 1               5                  10                  15      
Thr Ser Glu Asn Ser Ser Ser Val Gly Gly Arg Cys
            20                  25              


<210> 931
<211> 15
<212> PRT
<213> Homo sapiens

<400> 931
Val Phe Asn Ile Leu Phe Val Thr Ser Glu Asn Gly Ser Arg Asn
 1               5                  10                  15  


<210> 932
<211> 19
<212> PRT
<213> Homo sapiens

<400> 932
Arg Tyr Phe Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met
 1               5                  10                  15      
Ala Asn Leu
            


<210> 933
<211> 26
<212> PRT
<213> Homo sapiens

<400> 933
Arg Tyr Asp Gly Ala Val Gln Val Met Ala Thr Gln Asp Gly Ala Asn
 1               5                  10                  15      
Phe Thr Ala Ala Arg Gln Gly Tyr Arg Arg
            20                  25      


<210> 934
<211> 15
<212> PRT
<213> Homo sapiens

<400> 934
Arg Val Arg Ala Ser Ser Tyr Ser Ala Asn Gly Thr Ile Glu Tyr
 1               5                  10                  15  


<210> 935
<211> 32
<212> PRT
<213> Homo sapiens

<400> 935
Arg Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro
 1               5                  10                  15      
Glu Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys
            20                  25                  30          


<210> 936
<211> 18
<212> PRT
<213> Homo sapiens

<400> 936
Arg Asn Pro Ser Ala Ser Thr Phe Leu His Leu Ser Thr Asn Ser Phe
 1               5                  10                  15      
Arg Leu
        


<210> 937
<211> 31
<212> PRT
<213> Homo sapiens

<400> 937
Arg Asn Met Ser Gln Leu Met Glu Thr Gly Glu Val Ser Asp Asp Leu
 1               5                  10                  15      
Ala Ser Gln Leu Ile Tyr Gln Leu Val Ala Glu Leu Ala Lys Ala
            20                  25                  30      


<210> 938
<211> 11
<212> PRT
<213> Homo sapiens

<400> 938
Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr
 1               5                  10      


<210> 939
<211> 28
<212> PRT
<213> Homo sapiens

<400> 939
Arg Leu Phe Leu Gly Asn Tyr Thr Gly Asn Val Gly Asn Asp Ala Leu
 1               5                  10                  15      
Gln Tyr His Asn Asn Thr Ala Phe Ser Thr Lys Asp
            20                  25              


<210> 940
<211> 37
<212> PRT
<213> Homo sapiens

<400> 940
Arg Leu Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala
 1               5                  10                  15      
Gly Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser
            20                  25                  30          
Ser Gly Thr Arg Thr
        35          


<210> 941
<211> 40
<212> PRT
<213> Homo sapiens

<400> 941
Arg Ile Ala Gln Leu Arg Pro Glu Asp Leu Ala Gly Leu Ala Ala Leu
 1               5                  10                  15      
Gln Glu Leu Asp Val Ser Asn Leu Ser Leu Gln Ala Leu Pro Gly Asp
            20                  25                  30          
Leu Ser Gly Leu Phe Pro Arg Leu
        35                  40  


<210> 942
<211> 18
<212> PRT
<213> Homo sapiens

<400> 942
Arg His Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val
 1               5                  10                  15      
His Cys
        


<210> 943
<211> 18
<212> PRT
<213> Homo sapiens

<400> 943
Arg His Leu Thr Leu Ile Asp Leu Ser Asn Asn Ser Ile Ser Met Leu
 1               5                  10                  15      
Thr Asn
        


<210> 944
<211> 25
<212> PRT
<213> Homo sapiens

<400> 944
Arg His Cys Asp Gly Asn Val Ser Ser Cys Gly Asp His Pro Ser Glu
 1               5                  10                  15      
Gly Cys Phe Cys Pro Pro Asp Lys Val
            20                  25  


<210> 945
<211> 27
<212> PRT
<213> Homo sapiens

<400> 945
Arg Gly Asn Val Ala Val Thr Val Ser Gly His Thr Cys Gln His Trp
 1               5                  10                  15      
Ser Ala Gln Thr Pro His Thr His Asn Arg Thr
            20                  25          


<210> 946
<211> 21
<212> PRT
<213> Homo sapiens

<400> 946
Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala
 1               5                  10                  15      
Lys Asn Arg Lys Asp
            20      


<210> 947
<211> 33
<212> PRT
<213> Homo sapiens

<400> 947
Gln Arg His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser
 1               5                  10                  15      
Ala Val Gly Thr Phe Arg Met Arg His Met Pro Glu Val Pro Val Arg
            20                  25                  30          
Ile
    


<210> 948
<211> 19
<212> PRT
<213> Homo sapiens

<400> 948
Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu Ala Pro Asp Val
 1               5                  10                  15      
Trp Arg Ile
            


<210> 949
<211> 32
<212> PRT
<213> Homo sapiens

<400> 949
Asn Leu Leu Pro Ile Cys Leu Pro Asp Asn Asp Thr Phe Tyr Asp Leu
 1               5                  10                  15      
Gly Leu Met Gly Tyr Val Ser Gly Phe Gly Val Met Glu Glu Lys Ile
            20                  25                  30          


<210> 950
<211> 29
<212> PRT
<213> Homo sapiens

<400> 950
Met Met Ser Asn Gln Tyr Val Pro Val Lys Thr His Glu Glu Val Lys
 1               5                  10                  15      
Met Thr Leu Asn Asp Thr Leu Ala Lys Thr Asn Arg Glu
            20                  25                  


<210> 951
<211> 11
<212> PRT
<213> Homo sapiens

<400> 951
Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile
 1               5                  10      


<210> 952
<211> 19
<212> PRT
<213> Homo sapiens

<400> 952
Met Phe Glu His Phe Leu Leu His Arg Glu Gly Met Phe Asn Asp Thr
 1               5                  10                  15      
Leu Arg Leu
            


<210> 953
<211> 20
<212> PRT
<213> Homo sapiens

<400> 953
Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala Phe Gly Pro
 1               5                  10                  15      
Asn Leu Arg Tyr
            20  


<210> 954
<211> 34
<212> PRT
<213> Homo sapiens

<400> 954
Met Asp Asn Pro Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Val Ser
 1               5                  10                  15      
Phe Ser Pro Val Asp Thr Asn Ser Thr Ser Gly Asp Pro Val Glu Lys
            20                  25                  30          
Lys Asp
        


<210> 955
<211> 13
<212> PRT
<213> Homo sapiens

<400> 955
Leu Thr Phe Pro Asn Ser Ser Pro Gly Leu Arg Arg Gln
 1               5                  10              


<210> 956
<211> 25
<212> PRT
<213> Homo sapiens

<400> 956
Lys Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Phe Gln Glu Phe Gln
 1               5                  10                  15      
Thr Gln Asn Phe Asp Arg Phe Asp Asn
            20                  25  


<210> 957
<211> 35
<212> PRT
<213> Homo sapiens

<400> 957
Lys Val Glu Gly Ser Ser Ser His Leu Val Thr Phe Thr Val Leu Pro
 1               5                  10                  15      
Leu Glu Ile Gly Leu His Asn Ile Asn Phe Ser Leu Glu Thr Trp Phe
            20                  25                  30          
Gly Lys Glu
        35  


<210> 958
<211> 25
<212> PRT
<213> Homo sapiens

<400> 958
Lys Val Ala Ser His Leu Glu Val Asn Cys Asp Lys Arg Asn Leu Thr
 1               5                  10                  15      
Ala Leu Pro Pro Asp Leu Pro Lys Asp
            20                  25  


<210> 959
<211> 18
<212> PRT
<213> Homo sapiens

<400> 959
Lys Thr Gly Thr Asp Ser Asn Ser Thr Glu Ser Ser Glu Thr Ser Thr
 1               5                  10                  15      
Gly Ser
        


<210> 960
<211> 8
<212> PRT
<213> Homo sapiens

<400> 960
Lys Ser Tyr Asn Glu Thr Lys Ile
 1               5              


<210> 961
<211> 33
<212> PRT
<213> Homo sapiens

<400> 961
Lys Ser Asp Ser Ser Lys Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser
 1               5                  10                  15      
Lys Ser Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser Ser Asp Asn Ser
            20                  25                  30          
Asp
    


<210> 962
<211> 18
<212> PRT
<213> Homo sapiens

<400> 962
Lys Gln Met Asn Met Ser Pro Pro Pro Gly Asn Ala Gly Pro Val Ile
 1               5                  10                  15      
Met Ser
        


<210> 963
<211> 18
<212> PRT
<213> Homo sapiens

<400> 963
Lys Gln Ile Asn Ser Ser Ile Ser Gly Asn Leu Trp Asp Lys Asp Gln
 1               5                  10                  15      
Arg Ala
        


<210> 964
<211> 25
<212> PRT
<213> Homo sapiens

<400> 964
Lys Gln Phe Ser Leu Asn Trp Thr Tyr Gln Glu Cys Asn Asn Cys Ser
 1               5                  10                  15      
Glu Glu Met Phe Leu Gln Phe Arg Met
            20                  25  


<210> 965
<211> 24
<212> PRT
<213> Homo sapiens

<400> 965
Lys Asn Gly Asp Pro Glu Leu Asn Val Ile Gln Asn Tyr Asn Glu Gly
 1               5                  10                  15      
Ile Ile Asp Asn Leu Ser Lys Asp
            20                  


<210> 966
<211> 26
<212> PRT
<213> Homo sapiens

<400> 966
Lys Met Thr Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg Ile Ala
 1               5                  10                  15      
Glu Ala Met Leu Gln Thr Thr Thr Arg Pro
            20                  25      


<210> 967
<211> 14
<212> PRT
<213> Homo sapiens

<400> 967
Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala Gln Met
 1               5                  10                  


<210> 968
<211> 32
<212> PRT
<213> Homo sapiens

<400> 968
Lys Leu Tyr Gln Leu Gln Val Pro Leu Leu Gly Val Leu Asp Leu Ser
 1               5                  10                  15      
Thr Asn Val Tyr Ser Asn Leu Tyr Asn Trp Ser Ala Ser Tyr Ser Gly
            20                  25                  30          


<210> 969
<211> 21
<212> PRT
<213> Homo sapiens

<400> 969
Lys Leu Thr Lys Asn Met Leu Cys Ala Gly Tyr Lys Asn Glu Ser Tyr
 1               5                  10                  15      
Asp Ala Cys Lys Gly
            20      


<210> 970
<211> 23
<212> PRT
<213> Homo sapiens

<400> 970
Lys Lys Thr Leu Asp Glu Glu Arg Asn Ser Ser Ser Arg Ser Gly Ile
 1               5                  10                  15      
Thr Gly Thr Thr Asn Lys Lys
            20              


<210> 971
<211> 27
<212> PRT
<213> Homo sapiens

<400> 971
Lys His Leu Phe Glu Asp Ser Gln Asn Lys Leu Gly Ala Glu Met Val
 1               5                  10                  15      
Ile Asn Thr Ser Gly Lys Tyr Gly Tyr Lys Ser
            20                  25          


<210> 972
<211> 25
<212> PRT
<213> Homo sapiens

<400> 972
Lys Glu Pro His Leu Asn Tyr Ser Pro Thr Cys Leu Glu Pro Pro Val
 1               5                  10                  15      
Leu Ser Ile His Pro Gly Ala Ile Asp
            20                  25  


<210> 973
<211> 30
<212> PRT
<213> Homo sapiens

<400> 973
Lys Glu Glu Phe Val Ile His Thr Ile Phe Pro Pro Asn Gly Met Asn
 1               5                  10                  15      
Leu Tyr Lys Asn Asn His Ser Glu Ser Ser Ser Asn Arg Ser
            20                  25                  30  


<210> 974
<211> 21
<212> PRT
<213> Homo sapiens

<400> 974
Lys Glu Cys Met Glu Thr Leu Leu Ser Ser Asn Ala Ser Met Lys Glu
 1               5                  10                  15      
Glu Leu Glu Arg Val
            20      


<210> 975
<211> 15
<212> PRT
<213> Homo sapiens

<400> 975
Glu Tyr Asp Thr Ile Pro His Thr Asn Arg Thr Ile Leu Lys Glu
 1               5                  10                  15  


<210> 976
<211> 15
<212> PRT
<213> Homo sapiens

<400> 976
Ala Arg Asp Ser Asn Val Thr Leu Ala Pro Ser Gly Pro Lys Gly
 1               5                  10                  15  


<210> 977
<211> 16
<212> PRT
<213> Homo sapiens

<400> 977
Ala Glu Glu Glu Met Leu Glu Asn Val Ser Leu Val Cys Pro Lys Asp
 1               5                  10                  15      


<210> 978
<211> 13
<212> PRT
<213> Homo sapiens

<400> 978
Val Tyr Asn Pro Ser Gly Leu Asn Leu Ser Ile Lys Gly
 1               5                  10              


<210> 979
<211> 11
<212> PRT
<213> Homo sapiens

<400> 979
Arg Tyr Ser Gly Val Asn Met Thr Gly Phe Arg
 1               5                  10      


<210> 980
<211> 16
<212> PRT
<213> Homo sapiens

<400> 980
Arg Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe
 1               5                  10                  15      


<210> 981
<211> 28
<212> PRT
<213> Homo sapiens

<400> 981
Arg Val His Leu Thr Pro Val Glu Gly Val Pro Asp Ser Asp Tyr Ile
 1               5                  10                  15      
Asn Ala Ser Phe Ile Asn Gly Tyr Gln Glu Lys Asn
            20                  25              


<210> 982
<211> 17
<212> PRT
<213> Homo sapiens

<400> 982
Arg Val Glu Ser Asn Ser Ser Ala His Pro Trp Gly Leu Val Gly Lys
 1               5                  10                  15      
Ser
    


<210> 983
<211> 29
<212> PRT
<213> Homo sapiens

<400> 983
Arg Val Glu Ile Ile Ser Asn Asn Ser Ile Gln Ala Val Phe Asn Pro
 1               5                  10                  15      
Thr Gly Val Tyr Ala Pro Ser Gly Tyr Ser Tyr Arg Cys
            20                  25                  


<210> 984
<211> 14
<212> PRT
<213> Homo sapiens

<400> 984
Arg Thr Leu His Ser Thr Phe Gln Pro Asn Ile Ser Arg Tyr
 1               5                  10                  


<210> 985
<211> 16
<212> PRT
<213> Homo sapiens

<400> 985
Arg Ser Asn Ile Ser Ser Tyr Asp Gly Glu Tyr Ala Gln Pro Ser Thr
 1               5                  10                  15      


<210> 986
<211> 15
<212> PRT
<213> Homo sapiens

<400> 986
Arg Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu Val Arg Cys
 1               5                  10                  15  


<210> 987
<211> 29
<212> PRT
<213> Homo sapiens

<400> 987
Arg Arg Leu Cys Thr Asn Leu Val Val Asn Cys Trp Val Leu Gly Phe
 1               5                  10                  15      
Ile Trp Phe Leu Ile Pro Ile Val Asn Ile Ser Gln Met
            20                  25                  


<210> 988
<211> 20
<212> PRT
<213> Homo sapiens

<400> 988
Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala
 1               5                  10                  15      
Ala Gly Lys Arg
            20  


<210> 989
<211> 25
<212> PRT
<213> Homo sapiens

<400> 989
Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr Phe Asn
 1               5                  10                  15      
Glu Asn Gly Asp Ala Pro Gly Arg Tyr
            20                  25  


<210> 990
<211> 24
<212> PRT
<213> Homo sapiens

<400> 990
Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro Val Asn Val Thr Gln Gly
 1               5                  10                  15      
Gly Ala Arg Gln Glu Gln Arg Phe
            20                  


<210> 991
<211> 27
<212> PRT
<213> Homo sapiens

<400> 991
Arg Asn Pro Val Thr Ser Thr Asn Val Leu Gly Met Met Thr Ala Ile
 1               5                  10                  15      
Leu Gly Val Phe Leu Tyr Asn Lys Thr Lys Tyr
            20                  25          


<210> 992
<211> 13
<212> PRT
<213> Homo sapiens

<400> 992
Arg Lys Thr Thr Ser Asn Asn Phe Thr His Ser Arg Ala
 1               5                  10              


<210> 993
<211> 27
<212> PRT
<213> Homo sapiens

<400> 993
Arg Ile Ser Trp Glu Glu Tyr Asn Arg Thr Asn Thr Arg Val Thr His
 1               5                  10                  15      
Tyr Leu Pro Asn Val Thr Leu Glu Tyr Arg Val
            20                  25          


<210> 994
<211> 24
<212> PRT
<213> Homo sapiens

<400> 994
Arg Phe Gly Lys Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu
 1               5                  10                  15      
Leu Pro Asn Ser Thr Asp Lys Tyr
            20                  


<210> 995
<211> 27
<212> PRT
<213> Homo sapiens

<400> 995
Arg Glu Asn Leu Ser Ala Ala Phe Ser Arg Gln Leu Asn Val Asn Ala
 1               5                  10                  15      
Lys Pro Phe Val Pro Asn Val His Ala Ala Glu
            20                  25          


<210> 996
<211> 37
<212> PRT
<213> Homo sapiens

<400> 996
Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu Pro Gly Ile
 1               5                  10                  15      
Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu Ile Asp Ser
            20                  25                  30          
Leu Asn Ala Arg Asp
        35          


<210> 997
<211> 20
<212> PRT
<213> Homo sapiens

<400> 997
Arg Ala Ala Glu Asn Ala Ser Leu Gly Pro Thr Asn Gly Ser Lys Leu
 1               5                  10                  15      
Met Asn Arg Gln
            20  


<210> 998
<211> 27
<212> PRT
<213> Homo sapiens

<400> 998
Pro Trp Ala Ala Ala His Gly Gly Ala Met Met Asp Val Asn Ser Ser
 1               5                  10                  15      
Gly Arg Pro Asp Leu Tyr Gly His Leu Arg Ser
            20                  25          


<210> 999
<211> 22
<212> PRT
<213> Homo sapiens

<400> 999
Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val His Asp Cys Val
 1               5                  10                  15      
Asn Ile Thr Ile Lys Gln
            20          


<210> 1000
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1000
Met Thr Thr Glu Asn Pro Asn Gln Thr Val Val Ser His Phe Phe Leu
 1               5                  10                  15      
Glu Gly Leu Arg Tyr
            20      


<210> 1001
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1001
Met Gln Ser Gln Ala Gly Gly Asn Asn Thr Gly Ser Thr Pro Leu Arg
 1               5                  10                  15      
Lys
    


<210> 1002
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1002
Met Gly Met Ile Phe Thr Leu Phe Thr Ile Asn Val Ser Thr Asp Met
 1               5                  10                  15      
Arg His
        


<210> 1003
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1003
Lys Val Asn Ala Thr Asn Phe Gln Ala Leu Ala Ala Glu Phe Gly Gly
 1               5                  10                  15      
Glu Ser Phe Thr Ser Thr Phe Gln Thr Gln Ser Pro Pro Ser Phe Tyr
            20                  25                  30          
Arg Ala
        


<210> 1004
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1004
Lys Val Ala Asn Asn Val Thr Glu Phe Ile Phe Leu Gly Leu Ser Gln
 1               5                  10                  15      
Asp Ser Gly Met Arg Trp
            20          


<210> 1005
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1005
Lys Thr Pro Cys Met Pro Gln Ala Ala Ser Asn Thr Ser Leu Gly Leu
 1               5                  10                  15      
Gly Asp Leu Arg Val
            20      


<210> 1006
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1006
Lys Thr Ala Asn Ser Ser Pro Ile His Phe Ala Gly Ala Gln Thr Ser
 1               5                  10                  15      
Leu Pro Ala Phe Ser Pro Gly Arg Leu
            20                  25  


<210> 1007
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1007
Lys Ser Asn Gly Leu Met Phe Thr Asn Ile Met Met Gln Asn Thr Asn
 1               5                  10                  15      
Pro Ser Ala Ser Pro Glu Tyr Met Phe Ser Ser Asn Ile Glu Pro Glu
            20                  25                  30          
Pro Lys Asp
        35  


<210> 1008
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1008
Lys Ser Leu Met Asp Gln Leu Gln Gly Val Val Ser Asn Phe Ser Thr
 1               5                  10                  15      
Ala Ile Pro Asp Phe His Ala Val Leu Ala Gly Pro Gly Gly Pro Gly
            20                  25                  30          
Asn Gly Leu Arg Ser
        35          


<210> 1009
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1009
Lys Ser Ile Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser
 1               5                  10                  15      
Ser Ala Asp Leu Arg Ile
            20          


<210> 1010
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1010
Lys Ser Gly Lys Gly Asp Ser Thr Leu Gln Val Ser Ser Gly Leu Asn
 1               5                  10                  15      
Glu Asn Leu Thr Val Asn Gly Gly Gly Trp Asn Glu Lys Ser
            20                  25                  30  


<210> 1011
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1011
Lys Arg Thr Ile Tyr Leu Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn
 1               5                  10                  15      
Asn Asn Tyr Tyr Ser Val Glu Val
            20                  


<210> 1012
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1012
Lys Gln His Leu Gln Ile Asn Trp Thr Gly Leu Thr Asn Leu Leu Asp
 1               5                  10                  15      
Ala Pro Gly Ile Asn Asp Val Ser Asp Ser Leu
            20                  25          


<210> 1013
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1013
Lys Gln Asp Tyr Asn Met Asp Leu Glu Leu Asp Glu Tyr Tyr Asn Lys
 1               5                  10                  15      
Thr Leu Ala Thr Glu Asn Asn Thr
            20                  


<210> 1014
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1014
Lys Asn Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr
 1               5                  10                  15      
Gln Cys
        


<210> 1015
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1015
Lys Asn Lys Ile Ala Arg Leu Gly Asn Gly Ser Gln Asp Leu Asn His
 1               5                  10                  15      
Gly Val Asp Asn Glu Asn Gly Gly Arg Arg
            20                  25      


<210> 1016
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1016
Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly Gly Phe Gln Thr
 1               5                  10                  15      
Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe
            20                  25              


<210> 1017
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1017
Lys Met Pro Pro Gly Ile Asn Ser Ser Gln Ser Leu Pro Val Asp Asn
 1               5                  10                  15      
His Glu Lys
            


<210> 1018
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1018
Lys Met Glu Asn Glu Ser Ala Thr Glu Gly Glu Asp Ser Ala Met Thr
 1               5                  10                  15      
Asp Met Pro Pro Thr Glu Glu Val Thr Asp Ile Val Glu Met Arg Glu
            20                  25                  30          


<210> 1019
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1019
Lys Leu Arg Trp Asp Pro Ala Asp Tyr Glu Asn Val Thr Ser Ile Arg
 1               5                  10                  15      
Ile
    


<210> 1020
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1020
Lys Leu Gln Leu Trp Thr Asn Gly Ser Val Ala Tyr Ser Val Ala Arg
 1               5                  10                  15      
Glu
    


<210> 1021
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1021
Lys Leu Asn Thr Thr Ile Ser Thr Thr Ser Lys Gly Thr Leu Leu Pro
 1               5                  10                  15      
Asn Ser Ile Met Thr Ser Thr Leu Lys Asp Gln Gly Gly Ile Ser Arg
            20                  25                  30          
Thr
    


<210> 1022
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1022
Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser Asp Ala Tyr Leu
 1               5                  10                  15      
Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly
            20                  25              


<210> 1023
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1023
Lys Leu Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser
 1               5                  10                  15      
Thr Gln Arg Lys Arg Gln
            20          


<210> 1024
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1024
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala
 1               5                  10                  15      
Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met
            20                  25                  30          


<210> 1025
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1025
Lys Ile Asn Ser Ser Ser Val Cys Val Ser Ser Ile Ser Glu Asn Asp
 1               5                  10                  15      
Asn Gly Ile Ser Phe Thr Cys Arg Leu Gly Arg Asp
            20                  25              


<210> 1026
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1026
Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Ile Ile
 1               5                  10                  15      
Leu Ala Ile Ile Val Phe Val Phe Ala Leu Val Gly Lys Gln
            20                  25                  30  


<210> 1027
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1027
Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val Asn Phe Ser
 1               5                  10                  15      
Leu Ser Leu Leu Asn
            20      


<210> 1028
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1028
Lys Phe Arg Asn Pro Pro Leu Val Asn Gly Ser Leu Ala Leu Ala Phe
 1               5                  10                  15      
Gln Gly Thr Ala Pro Pro Pro Asn Trp Arg Arg Pro
            20                  25              


<210> 1029
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1029
Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile
 1               5                  10                  15      
Val Lys Ala
            


<210> 1030
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1030
Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser Gly
 1               5                  10                  15      
Leu Cys Ala Ile Ala
            20      


<210> 1031
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1031
Lys Ala Gly Asn Glu Thr Gln Ile Ser Glu Phe Leu Leu Leu Gly Phe
 1               5                  10                  15      
Ser Glu Lys Gln
            20  


<210> 1032
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1032
Lys Ala Glu Leu Ser Asn His Thr Arg Pro Val Ile Leu Val Pro Gly
 1               5                  10                  15      
Cys Leu Gly Asn Gln Leu Glu Ala Lys Leu
            20                  25      


<210> 1033
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1033
Ile Met Tyr Pro Ile Ala Val Met Gly Asn Ile Thr Ile Ile Leu Met
 1               5                  10                  15      
Ser Arg Leu
            


<210> 1034
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1034
Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr Arg Phe
 1               5                  10              


<210> 1035
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1035
Glu Asn Tyr Leu Glu Phe Gly Leu Glu Thr Gly Phe Thr Asn Phe Ser
 1               5                  10                  15      
Asp Ser Ala Met Gln Phe Leu Glu Lys Gln
            20                  25      


<210> 1036
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1036
Asp Lys Ala Lys Lys Glu His Glu Arg Ser Asn Ala Ser Pro Ala Ile
 1               5                  10                  15      
Phe Pro Glu Tyr Gln Leu Trp Glu Asp His Trp Ile Arg Cys
            20                  25                  30  


<210> 1037
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1037
Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr
 1               5                  10                  


<210> 1038
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1038
Met Gly Met Glu Gly Leu Leu Gln Asn Ser Thr Asn Phe Val Leu Thr
 1               5                  10                  15      
Gly Leu
        


<210> 1039
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1039
Met Glu Asn Gly Ser Tyr Thr Ser Tyr Phe Ile Leu Leu Gly
 1               5                  10                  


<210> 1040
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1040
Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala
 1               5                  10                  15      
Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser
            20                  25              


<210> 1041
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1041
Lys Ala Asn Asp Thr Ser Tyr Ile Arg Asp
 1               5                  10  


<210> 1042
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1042
Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu
 1               5                  10                  15      
Glu Arg Gln
            


<210> 1043
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1043
Lys Tyr Ser Val Ala Asn Asp Thr Gly Phe Val Asp Ile Pro Lys Gln
 1               5                  10                  15      


<210> 1044
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1044
Arg Leu Asn Leu Ser Glu Asn Tyr Thr Leu Ser Ile Ser Asn Ala Arg
 1               5                  10                  15      
Ile
    


<210> 1045
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1045
Arg Tyr Met Gln Asn Leu Thr Val Glu Gln Pro Ile Glu Val Lys Lys
 1               5                  10                  15      


<210> 1046
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1046
Arg Thr Val Asn Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His
 1               5                  10                  15      
Asp Glu Ala Asp Glu Ile Ser Asp Glu Asn Arg Glu
            20                  25              


<210> 1047
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1047
Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys Ser
 1               5                  10                  15      
Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp
            20                  25          


<210> 1048
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1048
Arg Asn Leu His Gln Ser Asn Thr Ser Arg Ala
 1               5                  10      


<210> 1049
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1049
Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu
 1               5                  10                  15      
Arg Leu
        


<210> 1050
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1050
Lys Phe Leu Tyr Asn Phe Thr Gln Ile Pro His Leu Ala Gly Thr Glu
 1               5                  10                  15      
Gln Asn Phe Gln Leu Ala Lys Gln
            20                  


<210> 1051
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1051
Arg Asn Cys Thr Thr Leu Gln Gly Leu Ala Pro Gly Thr Ala Tyr Leu
 1               5                  10                  15      
Val Thr Val Thr Ala Ala Phe Arg Ser Gly Arg Glu
            20                  25              


<210> 1052
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1052
Arg Val Gln Gly Cys Met Pro Gln Pro Gly Cys Asn Leu Leu Asn Gly
 1               5                  10                  15      
Thr Gln Glu Ile Gly Pro Val Gly Met Thr Glu Asn Cys Asn Arg Lys
            20                  25                  30          


<210> 1053
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1053
Arg Leu Leu Ala Asn Ser Ser Met Leu Gly Glu Gly Gln Val Leu Arg
 1               5                  10                  15      
Ser
    


<210> 1054
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1054
Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys
 1               5                  10  


<210> 1055
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1055
Lys Lys Leu Arg Leu Pro Asp Thr Gly Leu Tyr Asn Met Thr Asp Ser
 1               5                  10                  15      
Gly Thr
        


<210> 1056
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1056
Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val Gly His
 1               5                  10                  15      
Lys Leu
        


<210> 1057
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1057
Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr Tyr Arg
 1               5                  10                  15      
Phe
    


<210> 1058
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1058
Arg Thr Cys Val Ser Asn Cys Thr Ala Ser Gln Phe Val Cys Lys Asn
 1               5                  10                  15      


<210> 1059
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1059
Arg Met His Leu Asn Gly Ser Asn Val Gln Val Leu His Arg Thr
 1               5                  10                  15  


<210> 1060
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1060
Lys Ser Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His
 1               5                  10                  15      
Ser Gly Cys Glu Ala Lys Ser
            20              


<210> 1061
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1061
Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys Ile
 1               5                  10                  


<210> 1062
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1062
Arg Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys
 1               5                  10                  15      
Gly
    


<210> 1063
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1063
Arg Leu His Val Gly Asn Tyr Asn Gly Thr Ala Gly Asp Ala Leu Arg
 1               5                  10                  15      
Phe
    


<210> 1064
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1064
Met Leu Phe Thr Asn Glu Asp Asn Pro His Gly Asn Asp Ser Ala Lys
 1               5                  10                  15      
Ala Ser Arg Ala Arg Thr
            20          


<210> 1065
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1065
Lys Gln Met Glu Ser Ser Glu Gly Ser Ser Asn Thr Thr Glu Ala Thr
 1               5                  10                  15      
Ser Gly Ser Gly Val Arg Gly
            20              


<210> 1066
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1066
Lys His Met Gly Ser Ala Ser Glu Asp Ser Met Gly Pro Pro Arg Val
 1               5                  10                  15      
Gly Arg Val Leu Pro Thr Thr Asn Gly Thr Phe Pro Val Cys Ile Trp
            20                  25                  30          
Arg Gly
        


<210> 1067
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1067
Arg Gly Leu Cys Val Leu Ser Val Gly Ala Asn Leu Thr Thr Phe Asp
 1               5                  10                  15      
Gly Ala Arg Gly
            20  


<210> 1068
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1068
Lys Gly Gly Ala Val Ala Ala Asp Gly Arg Ile Glu Pro Gly Asp Met
 1               5                  10                  15      
Leu Leu Gln Val Asn Glu Ile Asn Phe Glu Asn Met Ser Asn Asp
            20                  25                  30      


<210> 1069
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1069
Arg Leu Val Ala Met Asn Met Pro Leu Asn Ser Asp Gly Thr Val Met
 1               5                  10                  15      
Phe Asn Ala Thr Leu Phe Ala Leu Val Arg Thr
            20                  25          


<210> 1070
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1070
Lys Ser Glu Tyr Met Val Ile Glu Glu Gly Gly Met Asn His Ser Ala
 1               5                  10                  15      
Phe Pro Gln Thr Pro Phe Lys Thr
            20                  


<210> 1071
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1071
Arg Glu Ala Glu Ser Leu Gln Pro Met Thr Val Val Gly Thr Asp Tyr
 1               5                  10                  15      
Val Phe His Asn Asp Thr Lys Val
            20                  


<210> 1072
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1072
Arg Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr
 1               5                  10                  15      
Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe
            20                  25              


<210> 1073
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1073
Lys Asp Leu Asn Gly Asn Val Phe Gln Asp Ala Val Phe Asn Gln Thr
 1               5                  10                  15      
Val Thr Val Ile Glu Arg Glu
            20              


<210> 1074
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1074
Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val
 1               5                  10                  15      
Ser Asn Lys Ala
            20  


<210> 1075
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1075
Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr
 1               5                  10                  15  


<210> 1076
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1076
Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met
 1               5                  10                  15      
Lys Leu
        


<210> 1077
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1077
Arg Leu Leu Ala Asn Tyr Ala Ser Gln Asn Ile Thr Tyr His Cys Lys
 1               5                  10                  15      
Asn
    


<210> 1078
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1078
Arg Leu Thr Phe Tyr Gly Asn Trp Ser Glu Lys Thr
 1               5                  10          


<210> 1079
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1079
Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu Leu Gln Asn
 1               5                  10                  15      
Ala Asp Pro Leu Lys Val
            20          


<210> 1080
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1080
Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu Asn Ser Lys
 1               5                  10                  15      
Ile
    


<210> 1081
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1081
Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu Pro Leu Arg
 1               5                  10                  15      
Met
    


<210> 1082
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1082
Lys Gln Asp Ile Leu Asn Asn Ser Leu Thr Thr Leu Ser Gln Asp Ile
 1               5                  10                  15      
Thr Lys Val
            


<210> 1083
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1083
Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu
 1               5                  10                  


<210> 1084
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1084
Lys Asn Thr Ser Val Gly Pro Leu Tyr
 1               5                  


<210> 1085
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1085
Met Leu Val Asn Gly Glu Asn Phe Gly Val Ser Leu Asn Ile Phe Pro
 1               5                  10                  15      
Ser Val Ala Ile Asn Lys Ser Ser Gly Ala Pro Arg Arg Val
            20                  25                  30  


<210> 1086
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1086
Lys Ile Thr Asn Ile Ser Ala Val Glu Met Thr Pro Leu Pro
 1               5                  10                  


<210> 1087
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1087
Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg Ile
 1               5                  10                  15  


<210> 1088
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1088
Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys
 1               5                  10                  15      
Ser Thr Thr Ala Met Lys Leu
            20              


<210> 1089
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1089
Lys Asn Ile Ser Leu Thr Lys Gln Ile Asp Gln Leu Ser Lys Asp
 1               5                  10                  15  


<210> 1090
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1090
Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn Gly Ser Glu Pro
 1               5                  10                  15      
Thr Gly Ala Tyr Pro Ile Lys Gly
            20                  


<210> 1091
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1091
Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly Phe Thr Val
 1               5                  10                  15      
Val Ala Pro Gly Lys Glu
            20          


<210> 1092
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1092
Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser
 1               5                  10                  15      
Gln Phe Leu Arg Gly
            20      


<210> 1093
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1093
Arg Leu Ser Thr Thr Glu Cys Val Asp Ala Gly Gly Glu Ser His Ala
 1               5                  10                  15      
Asn Asn Thr Lys Trp
            20      


<210> 1094
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1094
Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys Pro Ser Ala Gly
 1               5                  10                  15      
Thr Lys Cys
            


<210> 1095
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1095
Arg Lys Phe Asn Thr Thr Glu Arg Val
 1               5                  


<210> 1096
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1096
Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met
 1               5                  10                  15      
Glu Val Thr Val Tyr Arg Arg His
            20                  


<210> 1097
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1097
Lys Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys Val Phe Pro
 1               5                  10                  15      
Asp Lys Lys
            


<210> 1098
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1098
Lys Ser Glu Leu Val Asn Glu Thr Arg Trp
 1               5                  10  


<210> 1099
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1099
Phe Ser Val Thr Ser Asn Glu Thr Ile Thr Val Ser Pro Glu Tyr Val
 1               5                  10                  15      
Gly Ser Arg Leu
            20  


<210> 1100
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1100
Arg Ser Ser Ser Gly His Leu Phe Thr Leu Pro Gly Ala Thr Pro Gly
 1               5                  10                  15      
Gly Asp Pro Asn Ser Asn Asn Ser Asn Asn Lys Leu
            20                  25              


<210> 1101
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1101
Arg Tyr Met Leu Ala Ser Pro Asp Val Thr Ser Ile Leu Leu Thr Tyr
 1               5                  10                  15      
Asn Leu Ser Asn Thr Asn Ser Cys Asn Val Ser Pro Lys Lys Glu
            20                  25                  30      


<210> 1102
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1102
Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys
 1               5                  10                  


<210> 1103
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1103
Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser
 1               5                  10                  15      
Pro Ala Leu Lys Lys
            20      


<210> 1104
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1104
Pro Lys Trp Leu Asn Gly Ser Leu Leu Arg Ile Gly Pro Gly Lys Phe
 1               5                  10                  15      


<210> 1105
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1105
Lys Val Asp Ser Glu Glu Asn Thr Leu Asn Ser Gln Thr Asn Ala Thr
 1               5                  10                  15      
Ser Gly Met Asn Pro Asp Gly Val Leu Ser Lys Met
            20                  25              


<210> 1106
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1106
Arg Gln Asp Ala Val Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser
 1               5                  10                  15      
Pro Ala Leu Lys Lys Ala
            20          


<210> 1107
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1107
Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr
 1               5                  10  


<210> 1108
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1108
Thr Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu Arg Asn
 1               5                  10                  15  


<210> 1109
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1109
Lys Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg
 1               5                  10                  15      


<210> 1110
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1110
Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr Ser Asn
 1               5                  10                  15      
Thr Lys Val
            


<210> 1111
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1111
Arg Glu Leu Leu Leu His Leu Ile Asp Tyr Leu Val Thr Ser Asp Gly
 1               5                  10                  15      
Lys Asp Pro Glu Ile Thr Asn Leu Ile Asn Ser Thr Arg Ile
            20                  25                  30  


<210> 1112
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1112
Ile Met Asn Gly Thr Leu Tyr Ile Ala Ala Arg Asp
 1               5                  10          


<210> 1113
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1113
Lys Phe Asn Ser Thr Gln Ile Ala Ala Met Ala Pro Glu His Glu Glu
 1               5                  10                  15      
Pro Arg Ile
            


<210> 1114
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1114
Arg Ser Lys Lys Leu Gly Gly Ser Gly Gly Ser Asn Gly Ser Ser Ser
 1               5                  10                  15      
Gly Lys Thr Asp Ser Gly Gly Gly Ser Arg Arg Ser
            20                  25              


<210> 1115
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1115
Arg Met Ile Arg Thr Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn
 1               5                  10                  15      
Val Ser Gly Arg Ser Gly Arg Arg
            20                  


<210> 1116
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1116
Lys Gln Phe Ser Asn Met Gly Leu Leu Ser Gln Thr Glu Asp Asn Pro
 1               5                  10                  15      
Ser Ser Lys Met
            20  


<210> 1117
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1117
Ser Thr Ala Gln Leu Asn Leu Ser Asn Met Lys Ile
 1               5                  10          


<210> 1118
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1118
Arg Thr Ile Leu Glu Asn Asn Ser Gly Arg Ser Asn Ser Asn Pro Phe
 1               5                  10                  15      
Asn Lys Glu Glu Leu Thr Ala Ile Leu Lys Phe
            20                  25          


<210> 1119
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1119
Arg Ser Met Asn Pro Asn Val Ser Met Val Ser Ser Ala Ser Ser Ser
 1               5                  10                  15      
Pro Ser Ser Ser Arg Thr
            20          


<210> 1120
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1120
Lys Val Ala Pro Gln Asn Asp Ser Phe Gly Thr Gln Leu Pro Pro Met
 1               5                  10                  15      
His Gln
        


<210> 1121
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1121
Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser Ala Thr Glu Glu Thr
 1               5                  10                  15      
Leu Gln Glu Val Phe Glu Lys Ala
            20                  


<210> 1122
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1122
Lys Ser Val Val Glu Lys Met Lys Asn Ile Ser Asn His Leu Val Ile
 1               5                  10                  15      
Glu Ala Asn Leu Asp Gly Glu Leu Asn Leu Lys Ile
            20                  25              


<210> 1123
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1123
Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu Ala Asn Leu Val Gly
 1               5                  10                  15      
Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn
            20                  25          


<210> 1124
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1124
Lys Ile Ile Met Leu Pro Ser Ala Leu Asp Gln Leu Ser Gln Leu Asn
 1               5                  10                  15      
Ile Thr Tyr
            


<210> 1125
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1125
Lys His Tyr Gln Thr Val Phe Leu Met Arg Ser Asn Ser Thr Leu Asn
 1               5                  10                  15      
Lys His Asn Glu Asn Tyr Lys Gln Lys Lys
            20                  25      


<210> 1126
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1126
Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro
 1               5                  10                  15      
Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys
            20                  25              


<210> 1127
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1127
Lys Thr Gly Val Asn Ser Gly Val Met Leu Met Asn Met Thr Arg Met
 1               5                  10                  15      


<210> 1128
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1128
Val Phe Asp Asn Thr Thr Val Lys Thr
 1               5                  


<210> 1129
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1129
Arg Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly
 1               5                  10                  15      
Ser Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly
            20                  25                  30          


<210> 1130
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1130
Asn Ile Asp Gly Leu Asp Leu Asn Asn Leu Ser Glu Arg Ala Arg Gly
 1               5                  10                  15      


<210> 1131
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1131
Ala Gly Tyr Asn Val Ser Gly Ser Val Arg Ser
 1               5                  10      


<210> 1132
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1132
Lys Asn Val Thr Asn Lys Ala Ala Ser Gly Pro Lys Arg Thr Pro Gly
 1               5                  10                  15      
Ala Val His Thr
            20  


<210> 1133
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1133
Arg Ser Asn His Thr Gln Ala Thr Asn Asp Pro Pro Glu Val Thr Val
 1               5                  10                  15      
Phe Pro Lys Glu
            20  


<210> 1134
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1134
Lys Asn Leu Ser Cys Thr Asn Val Leu Gln Ser Asn Ser Thr Lys Lys
 1               5                  10                  15      


<210> 1135
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1135
Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser Asp Val
 1               5                  10                  15      
Glu Gln Asp Ala Glu Lys Lys Ala
            20                  


<210> 1136
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1136
Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro
 1               5                  10                  15      
Gln Gly Ser Arg Ser
            20      


<210> 1137
<211> 40
<212> PRT
<213> Homo sapiens

<400> 1137
Arg Glu Arg Glu Ala Ala Ser Lys Ser Asn Glu Val Val Ala Val Pro
 1               5                  10                  15      
Thr Asn Gly Thr Val Asn Asn Val Ala Gln Glu Pro Val Asn Thr Leu
            20                  25                  30          
Gly Asp Ile Ser Gly Asn Lys Thr
        35                  40  


<210> 1138
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1138
Ala Val Pro Thr Asn Gly Thr Val Asn Asn Val
 1               5                  10      


<210> 1139
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1139
Arg Ser Cys Cys Glu Gly Met Ile Cys Asn Val Glu Leu Pro Thr Asn
 1               5                  10                  15      
His Thr Asn Ala Val Phe Ala Val Met His Ala Gln Arg Thr
            20                  25                  30  


<210> 1140
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1140
Arg Gly Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn
 1               5                  10                  15      
Phe Ser Gly Arg Gly Gly Phe
            20              


<210> 1141
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1141
Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val
 1               5                  10              


<210> 1142
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1142
Val Asn Thr Ser Ser Val Ala Thr Ser Ser Met Lys Gly
 1               5                  10              


<210> 1143
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1143
Arg Thr Glu Asp Val Met Phe Ile Ser Asp Asn Glu Ser Phe Asn Pro
 1               5                  10                  15      
Ser Leu Trp Glu Glu Gln Arg Lys
            20                  


<210> 1144
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1144
Arg Arg Ser Tyr Ser Val Ser Gly Val Cys Gln Pro Ala Ile Pro Asn
 1               5                  10                  15      
Ser Ser Leu
            


<210> 1145
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1145
Arg Asn Asn Pro Val Ile Gln Ser Ser Thr Thr Thr Asn Thr Thr Thr
 1               5                  10                  15      
Thr Thr Thr Thr Thr Thr Ser Asn Thr Thr His Arg Val
            20                  25                  


<210> 1146
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1146
Arg Asn Leu Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu
 1               5                  10              


<210> 1147
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1147
Arg Asn Ile Thr Pro Leu Leu Leu Asp Met Val Val His Asn Asp Arg
 1               5                  10                  15      
Leu
    


<210> 1148
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1148
Arg Met Thr Asn Ser Ser Ser Ser Pro Ser Leu Leu Asn Asp Ser Ala
 1               5                  10                  15      
Lys Pro
        


<210> 1149
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1149
Arg Leu Met Pro Leu Glu Ala Gly Ile Pro Asp Pro Pro Asn Met Ser
 1               5                  10                  15      
Ala Glu Leu Ile Gln Leu Lys Ala Lys Glu Arg His
            20                  25              


<210> 1150
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1150
Arg Leu Ile Gly Glu Pro Asp Leu Val Val Ser Val Ile Pro Asn Asn
 1               5                  10                  15      
Ser Asn Glu Asn Ile Pro Arg Val
            20                  


<210> 1151
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1151
Arg Leu Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn
 1               5                  10              


<210> 1152
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1152
Arg Leu Ala Ser Ser Asn Ser Ser Gln Ser Leu Ala Pro Leu Met Met
 1               5                  10                  15      
Glu Val Pro Met Leu Ser Ser
            20              


<210> 1153
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1153
Arg Lys Arg Met Asn Thr Asn Pro Ser Arg Gly Pro Tyr His Phe Arg
 1               5                  10                  15      
Ala Pro Ser Arg Ile
            20      


<210> 1154
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1154
Arg Lys Cys Gln Leu Asn Leu Thr Asp Ser Glu Asn Arg Thr
 1               5                  10                  


<210> 1155
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1155
Arg Lys Ala Thr Met Ala Gly Gly Leu Ala Asn Leu Gln Asp Leu Glu
 1               5                  10                  15      
Asn Thr Thr Pro Ala Gln Pro Lys Asn
            20                  25  


<210> 1156
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1156
Arg Ile Tyr Ile Glu Asp Asn Leu Ser Asn Ser Asn Glu Val Glu Met
 1               5                  10                  15      
Glu Glu Lys Gly
            20  


<210> 1157
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1157
Arg Ile Asn Asp Ser Ala Val Met Leu Phe
 1               5                  10  


<210> 1158
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1158
Arg Ile Asp Arg Met Phe Pro Glu Met Ser Ile His Leu Ser Arg Pro
 1               5                  10                  15      
Asn Gly Thr Ser Ala Met Leu Leu Val Thr Leu Gly Lys Val
            20                  25                  30  


<210> 1159
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1159
Arg Asp Phe Asp Gln Asn Met Asn Asp Ser Cys Glu
 1               5                  10          


<210> 1160
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1160
Arg Cys Ser His Gly Met Val Glu Ala Asn Gly Leu Ile Tyr Val Cys
 1               5                  10                  15      
Gly Gly Ser Leu Gly Asn Asn Val Ser Gly Arg Val
            20                  25              


<210> 1161
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1161
Arg Ala Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser
 1               5                  10                  15      
Gln Met Gln Asp Thr Arg Gln
            20              


<210> 1162
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1162
Arg Ala Ser Leu Asn His Ser Thr Ala Phe
 1               5                  10  


<210> 1163
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1163
Leu Leu Leu Ser Asn Cys Ser Lys Ala
 1               5                  


<210> 1164
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1164
Lys Trp Arg Leu Ser Asn Asn Ser Val Val Glu Ile Ala Ser Leu Arg
 1               5                  10                  15      
Phe
    


<210> 1165
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1165
Lys Val Leu Asn His Ser Pro Met Ser Asp Ala Ser Val Asn Phe Asp
 1               5                  10                  15      
Tyr Lys Ser
            


<210> 1166
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1166
Lys Asn Met His Val Lys Glu Met His Thr Cys Thr Val Glu Gly Cys
 1               5                  10                  15      
Asn Ala Thr Phe
            20  


<210> 1167
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1167
Lys Met Ser Leu Val Met Pro Ala Met Ala Pro Asn Glu Thr Leu Ser
 1               5                  10                  15      
Gly Arg Gly
            


<210> 1168
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1168
Lys Met Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys
 1               5                  10                  15      
Ser
    


<210> 1169
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1169
Lys Leu Lys Gly Ala Ile Leu Thr Thr Met Leu Ala Thr Arg Asn Phe
 1               5                  10                  15      
Ser Ala Ala Lys Ser
            20      


<210> 1170
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1170
Lys Leu Gly Val Gly Ala Phe Asn Leu Thr Leu Ser Met Leu Pro
 1               5                  10                  15  


<210> 1171
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1171
Lys Leu Phe Lys Asn Ile Thr Val Glu Glu Met Asn Glu Leu Glu Arg
 1               5                  10                  15      


<210> 1172
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1172
Lys Lys Val Ala His Leu Ala Gly Cys Asn His Asn Ser Thr Gln Ile
 1               5                  10                  15      


<210> 1173
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1173
Lys Lys Ser Ser Leu Asp Ser Asn Ser Ser Glu Met Ala Ile Met Met
 1               5                  10                  15      
Gly Ala Asp Ala Lys Ile
            20          


<210> 1174
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1174
Lys Lys Leu Ser Asn Gly Ser Ile Val Pro Leu Glu Asp Ser Leu Asn
 1               5                  10                  15      
Leu Ile Glu Val Ala Thr Glu Val Pro Lys Arg Lys Thr
            20                  25                  


<210> 1175
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1175
Lys Lys Asp Gly Glu Asn Val Ser Met Lys Asp Pro Pro Asp Leu Leu
 1               5                  10                  15      
Asp Arg Gln Lys Cys
            20      


<210> 1176
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1176
Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu
 1               5                  10                  15      
Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp
            20                  25          


<210> 1177
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1177
Lys Gly Tyr Thr Pro Gly Glu Ser Ile Gln Ile Phe Ala Glu Ile Glu
 1               5                  10                  15      
Asn Cys Ser Ser Arg Met Val Val Pro Lys Ala
            20                  25          


<210> 1178
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1178
Lys Gly Val Ala Arg Val Val Asn Ile Thr Ser Pro Gly His Asp Ala
 1               5                  10                  15      
Ser Ser Arg Ser
            20  


<210> 1179
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1179
Lys Gly Ser Gly Gln Gln Ala Pro Ser Asn Val Ser Gly Gly Leu Leu
 1               5                  10                  15      
Val His Arg Gln
            20  


<210> 1180
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1180
Lys Gly Pro Val Thr Ser Ile Leu Pro Ser Gln Val Asn Ser Ser Pro
 1               5                  10                  15      
Val Ile Asn His Leu Leu Leu Gly Lys Lys
            20                  25      


<210> 1181
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1181
Lys Gly Phe Asn Trp Ser Ser Ala Leu Thr Lys His Lys Arg
 1               5                  10                  


<210> 1182
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1182
Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr Asp
 1               5                  10                  15      
Lys Ile
        


<210> 1183
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1183
Lys Asp Tyr Asn Ala Ser Ala Ser Thr Ile Ser Pro Pro Ser Ser Met
 1               5                  10                  15      
Glu Glu Asp Lys Phe
            20      


<210> 1184
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1184
Lys Asp Arg Asn Ala Ser Asn Asp Gly Phe Glu Met Cys Ser Leu Ser
 1               5                  10                  15      
Asp Phe Ser Ala Asn Glu Gln Lys Ser
            20                  25  


<210> 1185
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1185
Lys Asp Asn Ser Thr Ala Cys Ser His Pro Val Thr Lys His
 1               5                  10                  


<210> 1186
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1186
Glu Asn Val Ser Met Lys Asp Pro Pro Asp Leu Leu Asp Arg Gln Lys
 1               5                  10                  15      
Cys
    


<210> 1187
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1187
Asp Asn Met Ser Ser Leu Thr Ser Leu Ser Val Ser Thr Pro Lys Ser
 1               5                  10                  15      


<210> 1188
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1188
Cys Thr Leu His Pro Asn Asp Ser Leu Ala Met Glu Gly Pro Leu Ser
 1               5                  10                  15      
Arg Val Lys Ser
            20  


<210> 1189
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1189
Ala Val Ser Lys Gln Ser Ser Ser Thr Asn Tyr Thr Asn Glu Leu Lys
 1               5                  10                  15      
Ala
    


<210> 1190
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1190
Ala Gly Leu Asn Ser Ser Ala Thr Ser Thr Ala Asn Asn Ser Arg Cys
 1               5                  10                  15      


<210> 1191
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1191
Met Val Asn His Thr Met Phe Phe Asp Val Ala Val Asp Ser Glu Pro
 1               5                  10                  15      
Leu Asp His Val Ser Phe Glu Leu Phe Ala Glu Lys Phe
            20                  25                  


<210> 1192
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1192
Met Met Asn Asn Thr Asp Phe Leu Met Leu Asn
 1               5                  10      


<210> 1193
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1193
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala
 1               5                  10                  15      
Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys
            20                  25      


<210> 1194
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1194
Arg Val Leu Asn Ala Ser Ala Glu Ala Gln Arg Ala Ala Ala Arg Phe
 1               5                  10                  15      


<210> 1195
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1195
Arg Asn Arg His Asp Leu Leu Asn Val Ser Gln Gly Thr Val Phe Ile
 1               5                  10                  15      
Phe Trp Gly Pro Ser Ser Tyr Met Arg Arg
            20                  25      


<210> 1196
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1196
Arg Leu Met Asn Leu Thr Phe Leu Asp Leu Thr Arg
 1               5                  10          


<210> 1197
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1197
Arg Lys Val Leu Ile Asn Asn Ser Leu Asp Glu Pro Arg Ala
 1               5                  10                  


<210> 1198
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1198
Arg Ala Ser Ala Ser Ser Phe Leu Asn Met Ser Arg Cys Cys Ile Arg
 1               5                  10                  15      
Ala Leu Ala Glu His Lys Lys Lys Asn
            20                  25  


<210> 1199
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1199
Arg Ala Pro Ser Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro
 1               5                  10                  15      
Glu Asp Ala Lys Gly
            20      


<210> 1200
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1200
Arg Ala Met Leu Ala Ala Ile Tyr Asn Thr Thr Glu
 1               5                  10          


<210> 1201
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1201
Asn Ala Gln Phe Asp Gly Asn Asn Glu Thr Ile Lys Trp
 1               5                  10              


<210> 1202
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1202
Asp Ala Tyr Asn Thr Ser Asn Lys Glu
 1               5                  


<210> 1203
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1203
Asp Glu Asn Gly Thr Leu Asp Leu Ser Met Asn Lys Gln
 1               5                  10              


<210> 1204
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1204
Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser
 1               5                  10          


<210> 1205
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1205
Thr Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu
 1               5                  10                  15      
Lys Ala
        


<210> 1206
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1206
Thr Ser Glu Met Glu Glu Asn Leu Ala Asn Arg Ser
 1               5                  10          


<210> 1207
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1207
Arg Asn Ala Ser Val Gln Asp Ser Thr Asn Thr Pro Leu Gly
 1               5                  10                  


<210> 1208
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1208
Arg Glu Asn Met Ser Leu Pro Ser Asn Leu Gln Leu Asn Asp Leu Thr
 1               5                  10                  15      
Pro Asp Ser Arg Ala
            20      


<210> 1209
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1209
Lys Asn His Ser Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr
 1               5                  10                  15      


<210> 1210
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1210
Lys Leu Ala Ala Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser
 1               5                  10                  15      
Lys Leu
        


<210> 1211
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1211
Lys Ala Asn Phe Ser Ile Gly Pro Met Met Pro Val Leu
 1               5                  10              


<210> 1212
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1212
Arg Leu Gln Leu Asp Gly Asn Gln Ile Thr Asn Leu Thr Asp Ser Ser
 1               5                  10                  15      
Phe Gly
        


<210> 1213
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1213
Arg Leu Glu Gln Gln Met Asn Ser Ala Ser Gly Ser Ser Ser Asn Gly
 1               5                  10                  15      
Ser Ser Ile Asn Met Ser Gly Ile Asp Asn Gly Glu Gly Thr Arg Leu
            20                  25                  30          
Arg Asn
        


<210> 1214
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1214
Arg Asp Ala Thr Gly Asn Met Asn Asp Thr Ile Ile Ser Gly Met Asn
 1               5                  10                  15      
Cys Asn Gly Ser Ala Ala Cys Gly Leu Gly Tyr Asp Phe
            20                  25                  


<210> 1215
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1215
Arg Asp Ala Thr Gly Asn Met Asn Asp Thr Ile Ile Ser
 1               5                  10              


<210> 1216
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1216
Arg Ala Gly Val Leu Ser Ser Leu Ser Pro Val Asn Ser Ser Asn His
 1               5                  10                  15      


<210> 1217
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1217
Pro Gly Ala Tyr Asn Asn Thr Ala Leu Phe Glu Glu Ser Gly Leu Ile
 1               5                  10                  15      
Arg Ile
        


<210> 1218
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1218
Pro Gly Ala Pro Gly Gly Asn Ala Ser Ser Arg Thr
 1               5                  10          


<210> 1219
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1219
Met Ile Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser Thr Ile Ile Gly
 1               5                  10                  15      
Val Gly Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg Tyr
            20                  25                  


<210> 1220
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1220
Met Glu Gly Ala Gly Gly Asn Gly Ser Ser Asn Val His Val
 1               5                  10                  


<210> 1221
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1221
Lys Tyr Leu Lys Glu Ala Pro Leu Ala Ser Ser Ala Asn Gly Thr Glu
 1               5                  10                  15      
Lys Asn
        


<210> 1222
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1222
Lys Val Pro Thr Gly Thr Ile Thr Glu Val Ser Ser Thr Gly Val Asn
 1               5                  10                  15      
Ser Ser Ser Lys Ile
            20      


<210> 1223
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1223
Lys Ser Leu Lys His Gln Asn Ile Leu Leu Glu Val Asp Asp Phe Glu
 1               5                  10                  15      
Asn Arg Asn Gly Thr Asp Gly Leu Ser Tyr Asn Gly Ala Ile Ile Val
            20                  25                  30          
Ser Gly Lys Gln
        35      


<210> 1224
<211> 8
<212> PRT
<213> Homo sapiens

<400> 1224
Lys Asn Leu Ser Ser Val Ile Ile
 1               5              


<210> 1225
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1225
Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly Val Val
 1               5                  10                  15      
Val Phe Ser Leu Gly Ser Met Val Ser Asn Met Thr Ala Glu Arg Ala
            20                  25                  30          


<210> 1226
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1226
Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys
 1               5                  10  


<210> 1227
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1227
Gly Ser Met Ile Ser Asn Met Asn Ala Thr Arg Ala Glu Phe Gln Ala
 1               5                  10                  15      
Lys Ile
        


<210> 1228
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1228
Met Glu Asn Arg Asn Asn Met Thr Glu Phe Val Leu Leu Gly Leu Thr
 1               5                  10                  15      
Glu Asn Pro Lys Met Gln Lys Ile
            20                  


<210> 1229
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1229
Met Asp Gln Asn Gln His Leu Asn Lys Thr Ala Glu Ala Gln Pro Ser
 1               5                  10                  15      
Glu Asn Lys Lys
            20  


<210> 1230
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1230
Arg Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln Pro Asn Leu Thr
 1               5                  10                  15      
Val Ser Trp Asp Pro Arg Ile
            20              


<210> 1231
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1231
Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn Leu
 1               5                  10                  15      
Ser Glu Pro Thr Ala His Glu
            20              


<210> 1232
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1232
Arg Glu Ala Arg Glu Asn Leu Thr Val Phe Ser
 1               5                  10      


<210> 1233
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1233
Lys Gly Asn Met Ser Gly Asn Phe Thr Tyr Ile Ile Asp Lys Leu
 1               5                  10                  15  


<210> 1234
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1234
Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp
 1               5                  10                  15      
Tyr Val Gln Ala Gln Val Lys Cys
            20                  


<210> 1235
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1235
Lys Gln Glu Met Gly Gly Ile Val Thr Glu Pro Ile Arg Asp Tyr Asn
 1               5                  10                  15      
Ser Ser Arg Glu
            20  


<210> 1236
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1236
Arg Phe Gly Ser Gly Ala Ala Gly Gly Ser Gly Ser Ser Asn Ser Ser
 1               5                  10                  15      
Gly Asp Ala Leu Val Thr Arg Ile
            20                  


<210> 1237
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1237
Lys Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp
 1               5                  10                  15      
Gly Thr Thr Thr Ala Thr Val Leu Ala Arg Ser
            20                  25          


<210> 1238
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1238
Arg Ile Ile Asp Val Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg
 1               5                  10                  15      
Thr
    


<210> 1239
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1239
Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg
 1               5                  10                  15      
Ile
    


<210> 1240
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1240
Arg Ala Leu Trp Gln Ala Asp Thr Gln Val Thr Ser Gly Val Val Thr
 1               5                  10                  15      
Phe Thr Leu Gln Gln Leu Asn Ala Tyr Asn Arg Thr
            20                  25              


<210> 1241
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1241
Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile
 1               5                  10                  


<210> 1242
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1242
Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn Ser Met Ala
 1               5                  10                  15      
Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe Ser Pro Gln
            20                  25                  30          
Thr Asp Lys Leu
        35      


<210> 1243
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1243
Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile Tyr Ala Val Glu Glu Asn
 1               5                  10                  15      
Gln Glu Ser Thr Pro Val Val Ile Gln Gln Glu Thr Thr Gly Thr Pro
            20                  25                  30          
Arg Ser
        


<210> 1244
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1244
Lys Ile Met Asn Leu Thr Glu Phe Ser Met Val Asp Gly Met Trp Gln
 1               5                  10                  15      
Ala Gln Gly Tyr Pro Arg Asn Arg Leu
            20                  25  


<210> 1245
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1245
Met Glu Ser Tyr Asp Val Ile Ala Asn Gln Pro Val Val Ile Asp Asn
 1               5                  10                  15      
Gly Ser Gly Val Ile Lys Ala
            20              


<210> 1246
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1246
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
 1               5                  10                  15      
Cys Thr Lys Cys Ser His Phe Lys Asp
            20                  25  


<210> 1247
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1247
Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu Lys Asp
 1               5                  10                  


<210> 1248
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1248
Lys Phe Asp Leu Asn Lys Asn Cys Thr Val Thr
 1               5                  10      


<210> 1249
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1249
Arg Met Ile Glu Asn Gly Ser Leu Ser Phe Leu Pro Thr Leu Arg Glu
 1               5                  10                  15      


<210> 1250
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1250
Lys Glu Glu Lys Ala Asn Asp Ser Asn Pro Asn Glu Glu
 1               5                  10              


<210> 1251
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1251
Lys Gly Thr Glu Asn His Leu Leu Ala Ile Val Asn Gly Thr Lys Gly
 1               5                  10                  15      
Ser Arg Trp
            


<210> 1252
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1252
Arg Ala Gly Met Val Tyr Met Ala Gly Leu Val Phe Ala Val Gly Gly
 1               5                  10                  15      
Phe Asn Gly Ser Leu Arg Val Arg Thr
            20                  25  


<210> 1253
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1253
Lys Thr Lys Ala Thr Gln Ser Gln Arg Arg Asn Ser Ser Lys Thr
 1               5                  10                  15  


<210> 1254
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1254
Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val Thr Gln Pro
 1               5                  10                  15      
Lys Pro Lys Ile Glu Ser
            20          


<210> 1255
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1255
His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu
 1               5                  10                  15      


<210> 1256
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1256
Met Asn Gln Asn Thr Thr Glu Pro Val Ala Ala Thr Glu Thr Leu Ala
 1               5                  10                  15      
Glu Val Pro Glu His Val Leu Arg Gly
            20                  25  


<210> 1257
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1257
Met Ala Ala Gln Cys Val Thr Lys Val Ala Leu Asn Val Ser Cys Ala
 1               5                  10                  15      
Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser
            20                  25          


<210> 1258
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1258
Arg Leu Gln Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val
 1               5                  10                  15      
Lys Arg Asn
            


<210> 1259
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1259
Val Asn Ile Ser Tyr Val Asn Ile Phe Arg Met
 1               5                  10      


<210> 1260
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1260
Arg Thr Asn Val Leu Asn Asp Ala Tyr Glu Asn Leu Thr Arg Tyr Lys
 1               5                  10                  15      
Glu
    


<210> 1261
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1261
Arg Ser Val Gln Val Val Asn Leu Asp Pro Ala Ala Glu His Phe Asn
 1               5                  10                  15      
Tyr Ser Val Met Val Asp Ile Arg Glu Leu
            20                  25      


<210> 1262
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1262
Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu Ser Arg
 1               5                  10                  15      
Asn Lys Val
            


<210> 1263
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1263
Arg Arg His Asn Ser Ser Asp Gly Phe Asp Ser Ala Ile Gly Arg Pro
 1               5                  10                  15      
Asn Gly Gly Asn Phe Gly Arg Lys
            20                  


<210> 1264
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1264
Arg Asn Asn Gln Thr Ile Phe Glu Gln Thr Ile Asn Asp Leu Thr Phe
 1               5                  10                  15      
Asp Gly Ser Phe Val Lys Glu
            20              


<210> 1265
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1265
Arg Leu Thr Cys Asn Ala Thr Gly Ala Pro Ser Pro Thr Leu Met Trp
 1               5                  10                  15      
Leu Lys Asp
            


<210> 1266
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1266
Arg Lys Gln Glu Asn Ser Ser Gln Glu Asn Glu Asn Lys Thr
 1               5                  10                  


<210> 1267
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1267
Arg Lys His Thr Gly Ser Gly Ile Leu Ser Met Ala Asn Ala Gly Pro
 1               5                  10                  15      
Asn Thr Asn Gly Ser Gln Phe Phe
            20                  


<210> 1268
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1268
Arg Gly Val Ser Gly Asp Arg Asp Glu Asn Ser Phe Ser Leu Asn Ser
 1               5                  10                  15      
Ser Ile Ser Ser Ser Ala Arg Arg
            20                  


<210> 1269
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1269
Arg Phe Thr Leu Thr Gln Ser Glu Ala Asp Ala Asp Ile Leu Phe Asn
 1               5                  10                  15      
Phe Ser His Phe Lys Asp
            20          


<210> 1270
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1270
Arg Glu Phe Ser Ala Gly Thr Val Tyr Pro Glu Thr Asn Lys Thr Lys
 1               5                  10                  15      
Asn
    


<210> 1271
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1271
Arg Asp Asp Asn Ser Ala Ala Asn Asn Ser Ala Asn Glu Lys Glu
 1               5                  10                  15  


<210> 1272
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1272
Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala Val Phe Thr Asn
 1               5                  10                  15      
Asp Ile Asn Lys Ala
            20      


<210> 1273
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1273
Met Thr Leu Asn Asn Thr Ala Tyr Leu Leu Asp Lys Leu
 1               5                  10              


<210> 1274
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1274
Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln Glu
 1               5                  10                  15      
Glu Leu Lys Ser
            20  


<210> 1275
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1275
Lys Thr Met Asn Asn Ser Ala Glu Asn His Thr Ala Asn Ser Ser Met
 1               5                  10                  15      
Ala Tyr Pro Ser Leu Val Ala Met Ala Ser Gln Arg Gln
            20                  25                  


<210> 1276
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1276
Lys Arg Asp Phe Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln
 1               5                  10                  15      
Phe Ile Asn Leu Arg Glu
            20          


<210> 1277
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1277
Lys Gln Leu Phe Thr Leu Gln Thr Val Asn Ser Asn Gly Thr Ser Asp
 1               5                  10                  15      
Arg Thr
        


<210> 1278
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1278
Lys Asn Val Ser Gln Glu Asn Met Cys Ser Ala Ser Ala Ala Phe Lys
 1               5                  10                  15      
Ser
    


<210> 1279
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1279
Lys Glu Leu Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn
 1               5                  10                  15      
Lys Lys
        


<210> 1280
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1280
Lys Asp Val Pro Pro Ser Ile Asn Thr Thr Asn Ile Asp Thr Leu Leu
 1               5                  10                  15      
Val Ala Thr Asp Gln Thr Glu Arg Ile
            20                  25  


<210> 1281
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1281
Lys Ala Lys Arg Thr Ala Lys Val Leu Leu Asn Ser Ser Val Pro Pro
 1               5                  10                  15      
Ala Gly Ala Glu Glu Leu Ser
            20              


<210> 1282
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1282
Met Leu Asn Gly Thr Thr Leu Glu Ala Ala Met Leu Phe His
 1               5                  10                  


<210> 1283
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1283
Arg Arg Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser
 1               5                  10                  15      
Leu Gly Ser Arg Ile
            20      


<210> 1284
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1284
Lys Asp Asn Ala Thr Asp Ser Val Pro Leu Arg Thr
 1               5                  10          


<210> 1285
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1285
Lys Asn Leu Asn Tyr Ser Val Pro Glu Glu Gln Gly Ala Gly Thr Val
 1               5                  10                  15      
Ile Gly
        


<210> 1286
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1286
Lys Ile Asn Asn Thr His Ala Leu Val Ser Leu Leu Gln Asn Leu Asn
 1               5                  10                  15      
Lys Ala
        


<210> 1287
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1287
Lys Phe Ser Arg Asn Gln Ser Gln Leu Leu Gly His Leu Ser Val Asp
 1               5                  10                  15      
Met Ala Lys Ser
            20  


<210> 1288
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1288
Lys Glu Asn Glu Glu Phe Leu Ile Gly Phe Asn Ile Thr Ser Lys Gly
 1               5                  10                  15      
Arg Gln Leu Pro Lys Arg Arg
            20              


<210> 1289
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1289
Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met Thr Lys
 1               5                  10                  15      
Thr
    


<210> 1290
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1290
Arg Val Ile Asn Phe Tyr Ala Gly Ala Asn Gln Ser Met Asn Val Thr
 1               5                  10                  15      
Cys Ala Gly Lys Arg
            20      


<210> 1291
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1291
Arg Asn Ser Asn Tyr Thr Tyr Pro Ile Lys Pro Ala
 1               5                  10          


<210> 1292
<211> 39
<212> PRT
<213> Homo sapiens

<400> 1292
Arg Asn Leu Leu Glu Thr Gly Leu Asn Val Ser Asp Thr Val Thr Leu
 1               5                  10                  15      
Pro Thr Ala Pro Asn Met Asn Ser Glu Pro Thr Leu Gln Pro Gln Thr
            20                  25                  30          
Gly Glu Ile Thr Asn Arg Met
        35                  


<210> 1293
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1293
Arg Ala Thr Ala Asn Ser Gln Val Met Gly Ser Ala Asn Ser Thr Leu
 1               5                  10                  15      
Arg Ala
        


<210> 1294
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1294
Met Met Asn Asn Ser Tyr Gln Leu Ile Ala Arg Arg
 1               5                  10          


<210> 1295
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1295
Met Glu Arg Ala Pro Pro Asp Gly Pro Leu Asn Ala Ser Gly Ala Leu
 1               5                  10                  15      
Ala Gly Asp Ala Ala Ala Ala Gly Gly Ala Arg Gly
            20                  25              


<210> 1296
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1296
Lys Thr Thr Glu Phe Asp Thr Asn Ser Thr Asp Ile Ala Leu Lys Val
 1               5                  10                  15      


<210> 1297
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1297
Lys Met Asp Thr Glu Leu Ala Glu Ser Gly Ser Asn Phe Ser Val Gly
 1               5                  10                  15      
Gln Arg Gln
            


<210> 1298
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1298
Lys His Thr Gly Ser Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn
 1               5                  10                  15      
Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr
            20                  25                  


<210> 1299
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1299
Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr Ile Asn Lys Ser
 1               5                  10                  15      
Ala Leu Glu Thr Lys Thr
            20          


<210> 1300
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1300
Lys Ala Gln His Glu Phe Thr Glu Phe Val Gly Ala Thr Met Phe Gly
 1               5                  10                  15      
Thr Tyr Asn Val Ile Ser Leu Val Val Leu Leu Asn Met Leu Ile Ala
            20                  25                  30          
Met Met Asn Asn Ser Tyr
        35              


<210> 1301
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1301
Gly Thr Glu Ala Leu Ser Thr Asn His Ser Val Ile Val Asn Ser Pro
 1               5                  10                  15      
Val Ile Thr Ala Ala Ile Asn Lys Glu
            20                  25  


<210> 1302
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1302
Arg Lys Ile Gln Gln Glu Ser Leu Gly Ser Ala Pro Leu Met Gly Asp
 1               5                  10                  15      
Asp His Pro Asn Ala Ser Arg Asp
            20                  


<210> 1303
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1303
Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu
 1               5                  10          


<210> 1304
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1304
Arg Gly Ser Ala Asn Arg Thr Cys Gln Val Asn Gly Arg Trp
 1               5                  10                  


<210> 1305
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1305
Lys Val Val Met Asp Ile Pro Tyr Glu Leu Trp Asn Glu Thr Ser Ala
 1               5                  10                  15      
Glu Val Ala Asp Leu Lys Lys
            20              


<210> 1306
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1306
Lys Cys Val Val Glu Met Glu Gly Asn Gln Thr Val Leu His Pro Pro
 1               5                  10                  15      
Pro Ser Asn Thr Lys Gln
            20          


<210> 1307
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1307
Tyr Ile Ser Ala Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Glu
 1               5                  10                  15      
Arg Asp
        


<210> 1308
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1308
Lys Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile
 1               5                  10                  15      
Ser Leu Met Ala Thr Leu Lys Ala
            20                  


<210> 1309
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1309
Arg Val Met Ile Ser Ala Gly Asn Leu Gln Leu Pro Val Glu Ala Gly
 1               5                  10                  15      
Leu Val Glu Phe Thr Asn Ile Ser Gln Lys Leu
            20                  25          


<210> 1310
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1310
Arg Val Leu Gly Ser Ile Leu Asn Ala Ser Thr Val Ala Ala Ala Met
 1               5                  10                  15      
Cys Met Val Val Thr Arg Thr
            20              


<210> 1311
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1311
Arg Val Ile Ser Ala Met Val Asn Ser Leu Asp Asp Asn Gly Val Leu
 1               5                  10                  15      
Ile Gly Asn Trp Ser Gly Asp Tyr Ser Arg Gly
            20                  25          


<210> 1312
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1312
Arg Ser Pro Cys Ser Ile Asn Ala Ser Ile Ser Ser Ile Thr Ser Tyr
 1               5                  10                  15      
Thr Cys Phe
            


<210> 1313
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1313
Arg Met Glu Ser Gln Ala Thr Ser Ala Ser Ile Asn Asn Ser Asn Pro
 1               5                  10                  15      
Ser Thr Ser Glu Gln Ala Ser Asp Thr Ala Ser Ala Val Thr
            20                  25                  30  


<210> 1314
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1314
Arg Gly Ala Ala Ala Ala Pro Gly Asn Trp Ser Ser Arg Gln Arg Pro
 1               5                  10                  15      
Ala His Pro Arg Thr
            20      


<210> 1315
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1315
Arg Asp Gly Gly Glu Gly Cys Ser Trp Met Phe Gln Pro Met Asn Asn
 1               5                  10                  15      
Ser Lys Met Arg Val
            20      


<210> 1316
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1316
Pro Asp Thr Pro Pro Asp Thr Pro Pro Ala Met Lys Asn Ala Thr Ser
 1               5                  10                  15      
Ser Lys Gln
            


<210> 1317
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1317
Met Ser Ser Lys His Asn Met Ser Gly Gly Glu Phe Gln Gly Lys Arg
 1               5                  10                  15      
Glu
    


<210> 1318
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1318
Lys Val Leu Gly Ser Ser Thr Ser Ala Thr Asn Ser Thr Ser Val Ser
 1               5                  10                  15      
Ser Arg Lys
            


<210> 1319
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1319
Lys Gln Leu Leu Arg Asp Leu Ser Gly Leu Gln Gly Met Asn Gly Ser
 1               5                  10                  15      
Ile Gln Ala Lys Ser
            20      


<210> 1320
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1320
Lys Asn Thr Asn Gln Asn Ser Ser Ala His Pro Pro His Leu Asn Met
 1               5                  10                  15      
Asp Asp Thr Val Asn Gln Ser Asn Ile Glu Leu Lys Asn Val Asn Arg
            20                  25                  30          
Asn
    


<210> 1321
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1321
Lys Met Asn Asp Ser Asn Ser Ala Gly Ala Gly Gly Pro Val Lys Ile
 1               5                  10                  15      
Thr Glu Asn Arg Ser Lys Lys
            20              


<210> 1322
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1322
Lys Ile Asn Met Asn Gly Ile Asn Asn Ser Ser Gly Met Val Asp Ala
 1               5                  10                  15      
Arg Ser
        


<210> 1323
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1323
Lys Asp Tyr Pro Ser Asn Thr Thr Ser Ser Thr Ser Asn Ser Gly Asn
 1               5                  10                  15      
Glu Thr Ser Gly Ser Ser Thr Ile Gly Glu Thr Ser Lys Lys Lys Arg
            20                  25                  30          


<210> 1324
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1324
Lys Ala Ser Met Ile Ala Met Met Ala Gly Ser Asp Phe Ile Lys Thr
 1               5                  10                  15      
Ser Thr Gly Lys Glu Thr Val Asn Ala Thr Phe Pro Val Ala Ile Val
            20                  25                  30          
Met Leu Arg Ala
        35      


<210> 1325
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1325
Gly Asn Asn Met Ser Thr Pro Leu Pro Ala Ile Val Pro Ala Ala Arg
 1               5                  10                  15      
Lys
    


<210> 1326
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1326
Met Asp Pro Asn Cys Ser Cys Ala Ala Ser Asp Ser Cys Thr Cys Ala
 1               5                  10                  15      
Gly Ser Cys Lys Cys
            20      


<210> 1327
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1327
Met Ala Leu Tyr His Asn Ile Ser Gly Val Gly Leu Phe Leu His Pro
 1               5                  10                  15      
Val Gly Leu Glu Leu Leu Leu Asp His Arg Ala
            20                  25          


<210> 1328
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1328
Arg Gly Pro Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro
 1               5                  10                  15      
Lys Asn Gln Ser Tyr Met Val Arg Gly
            20                  25  


<210> 1329
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1329
Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu
 1               5                  10      


<210> 1330
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1330
Lys Met Tyr Ser Glu Gly Ser Asp Ile Val Pro Gln Ser Asn Glu Thr
 1               5                  10                  15      
Ala Leu His Tyr Phe Lys Lys
            20              


<210> 1331
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1331
Lys Leu Gln Asp Ile Phe Tyr Pro Asn Thr Ser Asn Cys Ala Lys Gly
 1               5                  10                  15      


<210> 1332
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1332
Arg Leu Val Leu Gly Thr Pro Gln Ser Asn Ser Pro Phe Gly Ala Ala
 1               5                  10                  15      
Val Gly Glu Gln Asn Glu Thr Leu Ile Arg Ile
            20                  25          


<210> 1333
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1333
Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
 1               5                  10                  


<210> 1334
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1334
Arg Glu Ser Trp Gly Gln Glu Ser Asn Ala Gly Asn Gln Thr Val Val
 1               5                  10                  15      
Arg Val
        


<210> 1335
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1335
Arg Asp Asn Leu Ser Glu Thr Ala Ser Thr Met Ala Leu Ala Gly Ala
 1               5                  10                  15      
Ser Ile Thr Gly Ser Leu Ser Gly Ser Ala Met Val Asn Cys Phe Asn
            20                  25                  30          
Arg Leu
        


<210> 1336
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1336
Arg Ala Leu Leu Ser Ile Thr Asp Asn Ser Ser Ser Ser Asp Ile Val
 1               5                  10                  15      
Glu Ser Ser Thr Ser Tyr Ile Lys Ile
            20                  25  


<210> 1337
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1337
Lys Asn Pro Glu Leu Ser Gly Ser Leu Met Thr Leu Ser Asn Val Ser
 1               5                  10                  15      
Cys Leu Ser Asn Thr Pro Ala Arg Lys Ile
            20                  25      


<210> 1338
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1338
Lys Ile Asn Ser Thr Ala Asp Leu Asp Phe Ile Gln Gln Ala Ile Ser
 1               5                  10                  15      
Tyr Ser Ser Phe Pro Phe Trp Met Gly Leu Ser Arg Arg Asn
            20                  25                  30  


<210> 1339
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1339
Met Met Gly His Gln Asn His Thr Phe Ser
 1               5                  10  


<210> 1340
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1340
Arg Met Ile Val Glu Ile His Leu Glu Glu Tyr Asn Asn Ile Ser Lys
 1               5                  10                  15      
Lys Pro Met Asn Leu Val Leu Phe Arg Phe
            20                  25      


<210> 1341
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1341
Lys Gly Gly Asn Asn Asp Ser Trp Met Asn Pro Leu Ala Lys Gln Phe
 1               5                  10                  15      
Ser Asn Met Gly Leu Leu Ser Gln Thr Glu Asp Asn Pro Ser
            20                  25                  30  


<210> 1342
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1342
Lys Glu Ser Leu Ile Met Asn His Val Leu Asn Thr Ser Gln Leu Ala
 1               5                  10                  15      
Ser Ser Tyr Gln Tyr Lys Lys Lys
            20                  


<210> 1343
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1343
Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser Gly Ser Gly Ser
 1               5                  10                  15      
Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala Arg Arg
            20                  25                  30  


<210> 1344
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1344
Lys Ile Lys Asp Gln Val Asn Gly Thr Ser Glu Asp Ser Ala Asp Gly
 1               5                  10                  15      
Ser Thr Val Gly Thr Ala Val Ser Ser Ser Asp
            20                  25          


<210> 1345
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1345
Tyr Pro Asp Pro Gln Ser Ala Asn His Met Asn Ser Ser Leu Leu Ser
 1               5                  10                  15      
Leu Tyr Arg Lys
            20  


<210> 1346
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1346
Tyr Asn Phe Thr Tyr Thr Gly Asp Gly Asp Ile Thr Leu Ile Thr Asp
 1               5                  10                  15      
Asn Asn Gly Asn Met Val Asn Val Arg Arg Asp
            20                  25          


<210> 1347
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1347
Tyr Lys Pro Leu Asn Asp Ser Val Arg Ala Gln Tyr Ser Asn Trp Leu
 1               5                  10                  15      
Leu Ala Gly Asn Leu Ala Leu Ser Pro Thr Gly Asn Ala Lys Lys Pro
            20                  25                  30          


<210> 1348
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1348
Tyr Asp Leu Lys Glu Gly Leu Leu Val Ser Pro Gly Ser Val Ile Met
 1               5                  10                  15      
Asn Gly Ser Asn Met Ala Asn Thr Ser Pro Ser Val Lys Ser Lys Glu
            20                  25                  30          


<210> 1349
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1349
Trp Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser
 1               5                  10                  15      
Ala Pro Arg Lys Asp
            20      


<210> 1350
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1350
Trp Asn Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile
 1               5                  10                  15      
Glu Gly Ala Ser Ala Leu Asn Arg Val Arg Trp
            20                  25          


<210> 1351
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1351
Trp Ala Gln Asn Gly Ser Met Ser Gln Pro Leu Gly Glu Ser Pro Ala
 1               5                  10                  15      
Thr Ala Thr Ala Thr Ala Thr Ala Thr Thr Arg Pro Ser Pro Thr Thr
            20                  25                  30          
Pro Ala Met Pro Lys Met
        35              


<210> 1352
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1352
Val Tyr Ile Val Gln Ser Gly Cys Gly Glu Ile Asn Asp Ser Leu Met
 1               5                  10                  15      
Glu Leu Leu Ile Met Ile Asn Ala Cys Lys Ile
            20                  25          


<210> 1353
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1353
Val Val Arg Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg His
 1               5                  10                  15  


<210> 1354
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1354
Val Thr Gln Gln Met Ser Asn Ile Ser Gly Ser Cys Ser Met Leu Gln
 1               5                  10                  15      
Gln Thr Ser Ile Ser Ser Pro Pro Thr Cys Ser Val Lys Ser
            20                  25                  30  


<210> 1355
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1355
Val Thr Ala Gly Ile Leu Glu Met Arg Asn Ala Leu Gly Asn Gln Ser
 1               5                  10                  15      
Thr Pro Ala Pro Pro Thr Gly Glu Val Ala Asp Thr Pro Leu Glu Pro
            20                  25                  30          
Gly Lys Val
        35  


<210> 1356
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1356
Val Ser Trp Glu Ile Leu Ser Asn Leu Ser Phe Leu Val Thr Ile Gln
 1               5                  10                  15      
Arg Ala
        


<210> 1357
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1357
Val Gln Asp Ser Val Asn Ile Ser Gly His Thr Asn Thr Asn Thr Leu
 1               5                  10                  15      
Lys Val
        


<210> 1358
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1358
Val Pro Thr Val Phe Ala Phe Gln Asp Pro Thr Gln Gln Val Arg Glu
 1               5                  10                  15      
Asn Thr Asp Pro Ala Ser Glu Arg Gly Asn Ala Ser Ser Ser Gln Lys
            20                  25                  30          
Glu
    


<210> 1359
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1359
Val Met Phe Leu Phe Gln Gly Asn Asn Gly Thr Val Leu Tyr Thr Gly
 1               5                  10                  15      
Asp Phe Arg Leu
            20  


<210> 1360
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1360
Val Leu Glu Met Glu Glu Ala Gly Ser Ile Phe Ala Cys Asn Met Glu
 1               5                  10                  15      
Gly Arg Ser Asn Ser Ser Gly Glu Val Lys Tyr
            20                  25          


<210> 1361
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1361
Val Lys Pro Tyr Val Asn Gly Thr Ser Pro Val Tyr Ser Arg Glu
 1               5                  10                  15  


<210> 1362
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1362
Val Ile Leu Ser Asn Asn Asn His Thr Glu Ile Gln Glu Ile Ser Leu
 1               5                  10                  15      
Ala Leu Arg Ser
            20  


<210> 1363
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1363
Val Ile His Asn Ala Ser Ile Met Asn Ala Glu Ala Ala Gly Gly Tyr
 1               5                  10                  15      
Arg Tyr
        


<210> 1364
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1364
Val His Ser Asp Phe Thr Ala Ala Ala Thr Arg Gly Ala Met Ala Val
 1               5                  10                  15      
Ile Asp Gly Asn Val Met Ala Ile Asn Pro Ser Glu Glu Thr Lys Met
            20                  25                  30          


<210> 1365
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1365
Val His Glu Glu Phe Asn Pro Asn Gln Ala Asn Gly Ser Tyr Ala Ser
 1               5                  10                  15      
Arg Arg
        


<210> 1366
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1366
Val Phe Asp Ala Ser Ala Pro Ala His Cys Gly Val Arg Val Gly Leu
 1               5                  10                  15      
Ser Ala Gln Pro Cys Pro Asn Lys Ser Ser Lys Ala
            20                  25              


<210> 1367
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1367
Val Glu Arg Pro Ser Ser Leu Leu Ser Leu Asn Thr Ser Asn Lys Gly
 1               5                  10                  15      


<210> 1368
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1368
Thr Val Thr Pro Val Ser Pro Ser Phe Ala His Asn Pro Lys Arg His
 1               5                  10                  15      
Asn Ser Ala Ser Val Glu Asn Val Ser Leu Arg Lys Ser
            20                  25                  


<210> 1369
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1369
Thr Val Ala Pro Gln Gly Gln Asp Met Ala Ser Ile Ala Pro Asp Asn
 1               5                  10                  15      
Arg Ser Lys Ser
            20  


<210> 1370
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1370
Thr Thr Asn Ser Thr Asn Pro Ser Pro Gln Gly Ser His Ser Ala Ile
 1               5                  10                  15      
Gly Leu Ser Gly Leu Asn Pro Ser Thr Gly
            20                  25      


<210> 1371
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1371
Thr Arg Gly Arg Ser Ile Ser Phe Pro Ala Leu Leu Pro Ile Pro Gly
 1               5                  10                  15      
Ser Asn Arg Ser Ser Val Ile Met Thr Ala Lys Pro
            20                  25              


<210> 1372
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1372
Thr Gln Ile Ile Asn Gly Ser Val Asp Val Asp Thr Glu Asp Arg Gln
 1               5                  10                  15      
Lys Arg
        


<210> 1373
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1373
Thr Pro Val Pro Gly Tyr Met Asn Asn Thr Val Asn Thr Met Arg Leu
 1               5                  10                  15      


<210> 1374
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1374
Thr Pro Lys Gly Asn Ser Ser Asn Gly Asn Ser Gly Ser Asn Ser Asn
 1               5                  10                  15      
Lys Ala
        


<210> 1375
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1375
Thr Pro Ala Asp Val Phe Ile Val Phe Thr Asp Asn Glu Thr Phe Ala
 1               5                  10                  15      
Gly Gly Val His Pro Ala Ile Ala Leu Arg Glu
            20                  25          


<210> 1376
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1376
Thr Asn Ala Ser Pro Glu Lys Thr Thr Tyr Asp Ser Ala Glu Glu Glu
 1               5                  10                  15      
Asn Lys Glu Asn Leu Tyr Ala Gly Lys Asn
            20                  25      


<210> 1377
<211> 41
<212> PRT
<213> Homo sapiens

<400> 1377
Thr Leu Met Ala Ala Phe Gln Gly Pro Gly Glu Asp Phe Ile Gly Gly
 1               5                  10                  15      
Ser Ile Phe Val Asn Val Thr Met Phe Ser Ser Gly Gly Glu Met Val
            20                  25                  30          
Gln Ala Glu Thr Ser Gly Val Lys Ile
        35                  40      


<210> 1378
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1378
Thr Lys Ser Arg Val Gly Met Gly Gly Met Glu Ala Lys Val Lys Ala
 1               5                  10                  15      
Ala Leu Trp Ala Leu Gln Gly Gly Thr Ser Val Val Ile Ala Asn Gly
            20                  25                  30          
Thr His Pro Lys Val
        35          


<210> 1379
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1379
Thr Lys Asn Val Asn Pro Asn Trp Ser Val Asn Val Lys Thr
 1               5                  10                  


<210> 1380
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1380
Thr Ile Leu Leu Asp Ala His Glu Ala Gly Ser Ala Glu Asn Asp Thr
 1               5                  10                  15      
Ala Asp Ala Glu Pro Pro Lys Ile
            20                  


<210> 1381
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1381
Thr Glu Arg Leu Leu Gly Glu Ala Ser Ser Asn Trp Ser Gln Ala Lys
 1               5                  10                  15      
Arg
    


<210> 1382
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1382
Thr Glu Leu Gln Leu Ala Ala Val Glu Thr Thr Ala Asn Ser Leu Met
 1               5                  10                  15      
Trp Ile Leu Tyr Asn Leu Ser Arg
            20                  


<210> 1383
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1383
Thr Asp Gly Thr Thr Ile Thr Glu Ser Ser Asn Leu Ser Glu Ile Glu
 1               5                  10                  15      
Ser Arg Leu
            


<210> 1384
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1384
Thr Asp Asp Thr Asn Val Thr Trp Leu Gln Leu Glu Thr Glu Ile Glu
 1               5                  10                  15      
Ala Leu Lys Glu Glu Leu Leu Leu Met Lys Lys Asn
            20                  25              


<210> 1385
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1385
Thr Ala Ala Asn Asn Leu Ser Val Ser Asn Ser Ala Ser Ser Leu Gln
 1               5                  10                  15      
Lys Asp
        


<210> 1386
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1386
Ser Tyr Gln Pro Trp Gly Asn Val Pro Asp Ala Asn Tyr Thr Ser Asp
 1               5                  10                  15      
Glu Glu Glu Glu Lys Gln
            20          


<210> 1387
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1387
Ser Tyr Phe Lys Cys Gly Glu Asn Val Ser Gln Lys Asn
 1               5                  10              


<210> 1388
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1388
Ser Val Pro Asp Asn Val Pro Gly Gln Asn Gly Ser Arg Arg
 1               5                  10                  


<210> 1389
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1389
Ser Val Asn Gly Ser Gly Ala Leu Gly Ser Thr Gly Gly Gly Gly Pro
 1               5                  10                  15      
Val Gly Ser Met Glu Asn Gly Lys Pro
            20                  25  


<210> 1390
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1390
Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu Ala His Ser Gly
 1               5                  10                  15      
Lys Val
        


<210> 1391
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1391
Ser Thr Ser Gly Leu Leu Asn Ser Thr Trp Pro Leu Pro Ser Ala Thr
 1               5                  10                  15      
Gln Arg Cys
            


<210> 1392
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1392
Ser Ser Ser Arg Glu Glu Asn Trp Ser Phe Leu Asp Trp Asp Ser Arg
 1               5                  10                  15      
Phe
    


<210> 1393
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1393
Ser Arg Gly Cys Asn Val Ser Arg Lys
 1               5                  


<210> 1394
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1394
Ser Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly
 1               5                  10              


<210> 1395
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1395
Ser Gln Glu Leu Asn Phe Val Met Asp Val Asn Ser Ser Lys Tyr
 1               5                  10                  15  


<210> 1396
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1396
Ser Gln Cys Gly Lys Met Ala Asn Lys Ala Asn Thr Ser Gly Asp Phe
 1               5                  10                  15      
Glu Lys Asp
            


<210> 1397
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1397
Ser Pro Gln Arg Ser Ser Met Asn Asn Gly Ser Pro Thr Ala Leu Ser
 1               5                  10                  15      
Gly Ser Lys Thr Asn Ser Pro Lys Asn
            20                  25  


<210> 1398
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1398
Ser Pro Lys Val Thr Lys Gln Asn Ser Leu Asn Asp Glu Gly Cys Gln
 1               5                  10                  15      
Ser Asp Leu Glu Asp Asn Val Ser Gln Gly Ser Ser Asp Ala Leu Leu
            20                  25                  30          
Leu Arg Gly
        35  


<210> 1399
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1399
Ser Pro Ala Arg Gln Asn Val Ser Ser Ala Ser Asn Pro Glu Asn Asp
 1               5                  10                  15      
Ser Ser His Val Arg Ile
            20          


<210> 1400
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1400
Ser Leu Ser Asn Pro Leu Asn Cys Ser Val Lys Thr
 1               5                  10          


<210> 1401
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1401
Ser Leu Ser Asn Ile Val Arg Asn Leu Thr Pro Ala Pro Leu Thr Ser
 1               5                  10                  15      
Thr Pro Pro Leu Arg Ser
            20          


<210> 1402
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1402
Ser Leu Arg Glu Asn Ser Ile Ser Pro Glu Gly Ala Gln Ala Ile Ala
 1               5                  10                  15      
His Ala Leu Cys Ala Asn Ser Thr Leu Lys Asn
            20                  25          


<210> 1403
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1403
Ser Leu Pro Ser Trp Lys Ser Leu Leu Asn Val Pro Met Glu Asp Val
 1               5                  10                  15      
Asn Leu Ser Ser Gly His Ile Ala Arg Val
            20                  25      


<210> 1404
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1404
Ser Leu Asn Gly Thr Ser Arg Gly Ser Ser Asp Leu Thr Ser Ala Arg
 1               5                  10                  15      
Asn
    


<210> 1405
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1405
Ser Lys Lys Glu His Ile Ser Ala Glu Asn Met Ser Leu Glu Thr Leu
 1               5                  10                  15      
Arg Asn
        


<210> 1406
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1406
Ser Ile Ser His Asp Asn Asn Asn Ile Ser Ser Thr Ser Glu Leu Gly
 1               5                  10                  15      
Thr Asp Leu Ala Asn Thr Lys Val
            20                  


<210> 1407
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1407
Ser Gly Asn Lys Val Ser Ile Thr Thr Thr Pro Phe Glu Asn Thr Ser
 1               5                  10                  15      
Ile Lys Thr Gly Pro Ala Arg Arg Asn
            20                  25  


<210> 1408
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1408
Ser Gly Glu Lys Asp Glu Ser Glu Val Ile Ser Gln Asn Glu Thr Cys
 1               5                  10                  15      
Ser Pro Ala Glu Val Glu Ser Asn Glu Lys Asp
            20                  25          


<210> 1409
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1409
Ser Phe Met Asn Val Ser Glu Ser His Phe Val Ser Ala Leu Thr Val
 1               5                  10                  15      
Val Phe Ile Asn Ser Lys Ser
            20              


<210> 1410
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1410
Ser Glu Glu Ser Asp Glu Asp Asp Gly Pro Ala Pro Val Ile Val Glu
 1               5                  10                  15      
Asn Glu Ser Tyr Val Asn Leu Lys Lys Lys Ile
            20                  25          


<210> 1411
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1411
Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn Ser Ser Ser
 1               5                  10                  15      
Gly Ile Ser Ser Pro Ser Arg Gln
            20                  


<210> 1412
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1412
Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln
 1               5                  10                  15      


<210> 1413
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1413
Arg Tyr Val Lys Thr Thr Gly Asn Ala Thr Val Asp His Leu Ser Lys
 1               5                  10                  15      
Tyr
    


<210> 1414
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1414
Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe Gly Ser Ser Pro Leu
 1               5                  10                  15      
Glu Pro Gly Ala Cys Asn Gly Ser Arg
            20                  25  


<210> 1415
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1415
Arg Tyr Thr Val Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg Phe
 1               5                  10                  15      
Lys Thr
        


<210> 1416
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1416
Arg Tyr Gln Gln Leu Ala Val Ala Leu Asp Ser Ser Tyr Val Thr Asn
 1               5                  10                  15      
Lys Gln Leu Asn Ile Thr Ile Glu Lys Leu
            20                  25      


<210> 1417
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1417
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
 1               5                  10                  15      
Ala Ala Ser Cys Phe Gly Ala Lys Lys
            20                  25  


<210> 1418
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1418
Arg Tyr Pro Asn Ser Ser Thr Glu Val Pro Glu Leu Pro Ile Ala Pro
 1               5                  10                  15      
Glu Ile Ala Leu Glu Leu Leu Met Asp Val Ser Phe Leu Asp Cys Glu
            20                  25                  30          
Ile Lys
        


<210> 1419
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1419
Arg Tyr Met Ile Tyr Glu Phe Trp Glu Asn Ser Ser Val Trp Asn Ser
 1               5                  10                  15      
His Leu Gln Thr Asn Tyr Ser Lys
            20                  


<210> 1420
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1420
Arg Tyr Leu Leu Gln Asn Thr Ala Leu Glu Val Phe Met Ala Asn Arg
 1               5                  10                  15      
Thr
    


<210> 1421
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1421
Arg Tyr Leu Phe Pro Glu Val Asp Met Thr Ser Thr Asn Phe Thr Gly
 1               5                  10                  15      
Leu Ser
        


<210> 1422
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1422
Arg Tyr His Thr Glu Ser Leu Gln Asn Met Ser Lys
 1               5                  10          


<210> 1423
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1423
Arg Tyr Gly Asn Thr Thr Gln Asn Val Pro His Asn Pro Arg Arg
 1               5                  10                  15  


<210> 1424
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1424
Arg Tyr Gly Asp Leu Leu Tyr Lys Ser Leu Val Pro Val Pro Asn Ser
 1               5                  10                  15      
Ser Ser Ser Ser Ser Ser Ser Asn Ser Leu Val Ser Ala Ala Glu Asn
            20                  25                  30          
Pro Pro Gln Arg Leu
        35          


<210> 1425
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1425
Arg Tyr Phe Asn Pro Val Asp Gln Glu Asn Ala Leu Ile Ala Ala Ile
 1               5                  10                  15      
Ala Asn Trp Ser Glu Leu Ala Ser Met Pro Val Gly Arg Ser
            20                  25                  30  


<210> 1426
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1426
Arg Tyr Asp Asn Val Thr Ile Leu Phe Ser Gly Ile Val Gly Phe Asn
 1               5                  10                  15      
Ala Phe Cys Ser Lys His Ala Ser Gly Glu Gly Ala Met Lys Ile Val
            20                  25                  30          
Asn Leu Leu
        35  


<210> 1427
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1427
Arg Tyr Asp Leu Thr Gly Trp Leu His Arg Ala Lys Pro Asn Leu Ser
 1               5                  10                  15      
Ala Leu Asp Ala Pro Gln Val Leu His Gln Ser Lys Arg
            20                  25                  


<210> 1428
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1428
Arg Tyr Asp Ala Gln Leu Ile Leu Glu Asn Asn Ser Gly Ile Pro Lys
 1               5                  10                  15      
Leu
    


<210> 1429
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1429
Arg Tyr Ala Thr Gln Ser Asn His Ser Gly Ile Ala Thr Ser Gln Lys
 1               5                  10                  15      


<210> 1430
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1430
Arg Trp Leu Gly Ser Thr Gly Val Thr Cys Gly Val Arg Arg Gln Ile
 1               5                  10                  15      
Ser Glu Met Asn Gly Asn Ile Ser Arg Leu
            20                  25      


<210> 1431
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1431
Arg Val Val Asn Leu Glu Ala Leu Gln Met Leu Ser Val Asn Thr Thr
 1               5                  10                  15      
Leu Glu Glu Leu Lys Ile
            20          


<210> 1432
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1432
Arg Val Thr Ala Leu Glu Gly Tyr Gln Ile Gly Gln Val Ala Cys Gly
 1               5                  10                  15      
Leu Asn His Thr Leu Ala Val
            20              


<210> 1433
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1433
Arg Val Ser Thr Asn Gly Ser Asp Asp Pro Glu Asp Ala Gly Ala Gly
 1               5                  10                  15      
Glu Asn Arg Arg Val
            20      


<210> 1434
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1434
Arg Val Ser Thr Met Asn His Pro Gln Met Gln Ala Pro Ser Gly Met
 1               5                  10                  15      
Asn Gly Thr Ser Leu Ser His Leu Ser Asn Gly Glu Ser Lys Ser
            20                  25                  30      


<210> 1435
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1435
Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile Ser Ser Leu
 1               5                  10                  15      
Phe Glu Arg Thr
            20  


<210> 1436
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1436
Arg Val Arg Arg Thr Asp Asp Thr Pro Val Val Leu Val Gly Asn Lys
 1               5                  10                  15      
Ser Asp Leu Lys Gln Leu Arg Gln Val Thr Lys Glu
            20                  25              


<210> 1437
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1437
Arg Val Gln Asn Thr Ser Leu Glu His Arg Gly Tyr His Gly Ser Gly
 1               5                  10                  15      
Thr Asp Gly Glu Ser Ser Gly Arg Arg Gly
            20                  25      


<210> 1438
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1438
Arg Val Gln Asn Thr Ser Leu Glu Ala Ile Val Gln Asn Ala Ser Ser
 1               5                  10                  15      
Asp Asn Gln Gly Ile Gln Leu Ser Ala Val Gln Ala Ala Arg Lys
            20                  25                  30      


<210> 1439
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1439
Arg Val Pro Pro Thr Leu Asn Ser Ser Pro Cys Gly Gly Phe Thr Leu
 1               5                  10                  15      
Cys Lys Ala
            


<210> 1440
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1440
Arg Val Pro Gly Gly Ser Pro Arg Thr Pro Asn Arg Ser Val Ser Ser
 1               5                  10                  15      
Asn Val Ala Ser Val Ser Pro Ile Pro Ala Gly Ser Lys Lys
            20                  25                  30  


<210> 1441
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1441
Arg Val Leu Asn Thr Ser Ser Leu Glu Ser Ala Thr Asp Glu Ala Gly
 1               5                  10                  15      
Ser Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Arg Cys
            20                  25                  30      


<210> 1442
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1442
Arg Val Leu Glu Leu Asn Ala Ser Asp Glu Arg Gly Ile Gln Val Val
 1               5                  10                  15      
Arg Glu Lys Val
            20  


<210> 1443
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1443
Arg Val Leu Ala Pro Ile Leu Pro Asp Asn Phe Ser Thr Pro Thr Gly
 1               5                  10                  15      
Ser Arg Thr
            


<210> 1444
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1444
Arg Val Lys Arg Asn Gln Glu Asn Phe Ser Ser Val Leu Tyr Lys Glu
 1               5                  10                  15      


<210> 1445
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1445
Arg Val Lys Asn Gly Ser Arg Val Val Ser Thr Ala Leu Leu Ser Ser
 1               5                  10                  15      
Tyr His Lys Gly Ile Ala
            20          


<210> 1446
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1446
Arg Val Phe Thr Glu Glu Ala Lys Asp Ser Leu Asn Thr Ser Glu Asn
 1               5                  10                  15      
Asp Ser Glu His Gln Thr
            20          


<210> 1447
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1447
Arg Val Phe Phe Ala Gly Phe Ser Asn Ala Thr Val Asp Asn Ser Ile
 1               5                  10                  15      
Leu Leu Arg Leu
            20  


<210> 1448
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1448
Arg Val Glu Asn Gly Ser Ser Asp Glu Asn Ala Thr Ala Leu Pro Gly
 1               5                  10                  15      
Thr Trp Arg Arg
            20  


<210> 1449
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1449
Arg Val Glu Phe Met Asp Asn Thr Ser Arg Ser
 1               5                  10      


<210> 1450
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1450
Arg Thr Thr Ser Thr Leu Ser Leu Ser Ala Glu Asp Ser Gln Ser Thr
 1               5                  10                  15      
Glu Ser Asn Met Ser Val Pro Lys Lys
            20                  25  


<210> 1451
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1451
Arg Thr Thr Gln Arg Ile Val Ala Pro Pro Gly Gly Arg Ala Asn Ile
 1               5                  10                  15      
Thr Ser Leu Gly
            20  


<210> 1452
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1452
Arg Thr Ser Arg Lys Ser Ala Leu Arg Ala Gly Asn Asp Ser Ala Met
 1               5                  10                  15      
Ala Asp Gly Glu Gly Tyr Arg Asn
            20                  


<210> 1453
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1453
Arg Thr Ser Glu His Gln Val Asp Leu Lys Val Asp Pro Ser Gln Pro
 1               5                  10                  15      
Ser Asn Val Ser His Lys Leu Trp Thr Ala Ala Gly
            20                  25              


<210> 1454
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1454
Arg Thr Gln Asn Leu Ser Gln Pro Ser Thr Gly Ile Pro Ser Gly Glu
 1               5                  10                  15      
Pro Gly His Ser Ala Gly Gly Ala Ala Gly Ser Arg Cys Thr Arg Ser
            20                  25                  30          
Met Phe Arg Lys
        35      


<210> 1455
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1455
Arg Thr Pro Tyr Arg Asp Met Met Leu Glu Asn Tyr Ser Leu Leu Leu
 1               5                  10                  15      
Ser Val
        


<210> 1456
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1456
Arg Thr Pro Gln Val Ile Gly Val Met Gln Ser Gln Asn Ser Ser Ala
 1               5                  10                  15      
Gly Asn Arg Gly
            20  


<210> 1457
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1457
Arg Thr Pro Asn Ser Ser Cys Ser Thr Pro Ser Arg Thr Ser Ser Gly
 1               5                  10                  15      
Leu Phe Pro Arg Ile
            20      


<210> 1458
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1458
Arg Thr Pro Met Asn Ser Ser Trp Leu Pro Gly Ser Pro Met Pro Gln
 1               5                  10                  15      
Ala Gln Ser Pro Glu Glu Gly Gln Arg Pro
            20                  25      


<210> 1459
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1459
Arg Thr Asn Ser Arg Leu Ser His Met Pro Pro Leu Pro Leu Asn Pro
 1               5                  10                  15      
Ser Ser Asn Pro Thr Ser Leu
            20              


<210> 1460
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1460
Arg Thr Asn Phe Thr Leu Ala Glu Leu Gly Ile Cys Glu Pro Ser Pro
 1               5                  10                  15      
His Arg Ser Gly Tyr Cys Ser Asp Met Gly Ile Leu His Gln Gly
            20                  25                  30      


<210> 1461
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1461
Arg Thr Leu Ile Ala Pro Gln Gly Tyr Pro Asn Pro Glu Asn Phe Ser
 1               5                  10                  15      
Trp Thr Glu
            


<210> 1462
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1462
Arg Thr Lys Asp Ala Gly Leu Gly Val Tyr Ser Leu Ala Leu Leu Asn
 1               5                  10                  15      
Asn Val Ser Tyr Asn Val Val Glu Phe Ser Lys Ser
            20                  25              


<210> 1463
<211> 39
<212> PRT
<213> Homo sapiens

<400> 1463
Arg Thr Ile Gly Ile Phe Trp Leu Asn Ala Ser Glu Thr Leu Val Glu
 1               5                  10                  15      
Ile Asn Thr Glu Pro Ala Val Glu Tyr Thr Leu Thr Gln Met Gly Pro
            20                  25                  30          
Val Ala Ala Lys Gln Lys Val
        35                  


<210> 1464
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1464
Arg Thr His Lys Met Asn Val Ser Pro Val Pro Pro Leu Arg Arg
 1               5                  10                  15  


<210> 1465
<211> 41
<212> PRT
<213> Homo sapiens

<400> 1465
Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly
 1               5                  10                  15      
Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro
            20                  25                  30          
Gly Thr Gly Gln Asn Pro Thr Arg Thr
        35                  40      


<210> 1466
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1466
Arg Thr Gly Leu Leu Lys Gln Thr His Ile Ala Pro Lys Pro Ala Ala
 1               5                  10                  15      
His Leu Ala Ala Pro Ala Asn Gly Ser Ala Pro Ser
            20                  25              


<210> 1467
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1467
Arg Thr Gly Gly Ile Gly Asp Ser Arg Pro Pro Ser Phe His Pro Asn
 1               5                  10                  15      
Val Ala Ser Ser Arg Asp Gly Met Asp Asn Glu Thr Gly Thr Glu Ser
            20                  25                  30          
Met Val Ser His Arg Arg
        35              


<210> 1468
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1468
Arg Thr Glu Ser Gln Leu Thr Pro Cys Ile Arg Asn Val Thr Ser Pro
 1               5                  10                  15      
Thr Arg Gln
            


<210> 1469
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1469
Arg Thr Glu Gly Asn Ile Phe Asp Ser Leu Ile Gly Gly Asn Ala Ser
 1               5                  10                  15      
Ala Glu Gly Pro Glu Gly Lys Gly
            20                  


<210> 1470
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1470
Arg Thr Ala Ser Ile Trp Val Pro Pro Leu Gln Glu Arg Asn Ser Ser
 1               5                  10                  15      
Trp Asp Arg Ile
            20  


<210> 1471
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1471
Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val Ala Ala Arg
 1               5                  10                  15      
Glu
    


<210> 1472
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1472
Arg Ser Tyr Phe Val Val Val Asn His Ser Gln Ser Gln Asp Thr Val
 1               5                  10                  15      
Thr Thr Gly Glu Ala Leu Asn Val Ile Pro Gly Ala Gln Glu Lys Lys
            20                  25                  30          
Ala
    


<210> 1473
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1473
Arg Ser Val Arg Lys Asn Leu Thr Tyr Ser Cys Arg Ser Asn Gln Asp
 1               5                  10                  15      
Cys Ile Ile Asn Lys His
            20          


<210> 1474
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1474
Arg Ser Thr Val Gly Leu Ser Leu Ile Ser Pro Asn Asn Met Ser Phe
 1               5                  10                  15      
Ala Thr Lys Lys
            20  


<210> 1475
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1475
Arg Ser Ser Thr Ser Ser Ile Asp Ser Asn Val Ser Ser Lys Ser
 1               5                  10                  15  


<210> 1476
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1476
Arg Ser Ser Asn Ser Ser Val Ser Gly Thr Lys Lys Glu Asp Ser Thr
 1               5                  10                  15      
Ala Lys Ile His Ala
            20      


<210> 1477
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1477
Arg Ser Ser Asp Met Asp Gln Gln Glu Asp Met Ile Ser Gly Val Glu
 1               5                  10                  15      
Asn Ser Asn Val Ser Glu Asn Asp Ile Pro Phe Asn Val Gln Tyr Pro
            20                  25                  30          
Gly Gln Thr Ser Lys Thr
        35              


<210> 1478
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1478
Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu Asn Ser Ser
 1               5                  10                  15      
Pro Arg Gly Arg Tyr
            20      


<210> 1479
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1479
Arg Ser Arg Asp Phe Ser Ala Ala Pro Gln Asn Thr Thr Gln Asn Phe
 1               5                  10                  15      
Leu Val Asn Gly Arg Ile Arg Lys
            20                  


<210> 1480
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1480
Arg Ser Arg Ala Thr Ile Phe Glu Ile Asn Ala Ser Ser Arg Asp Leu
 1               5                  10                  15      
Cys Ser Gln Val Met Arg Ala Lys Arg Gln
            20                  25      


<210> 1481
<211> 40
<212> PRT
<213> Homo sapiens

<400> 1481
Arg Ser Gln Ser Ser Ser Gln Ser Pro Ala Ser His Arg Asn Pro Thr
 1               5                  10                  15      
Gly Ala His Ser Ser Ser Gly His Gln Ser Gln Ser Pro Asn Thr Ser
            20                  25                  30          
Pro Pro Pro Lys Arg His Lys Lys
        35                  40  


<210> 1482
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1482
Arg Ser Gln Ser Leu Ile Phe Leu Asn Leu Ser Thr Asn Asn Leu Leu
 1               5                  10                  15      
Asp Asp
        


<210> 1483
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1483
Arg Ser Gln Ser Ala Asn Gln Val Cys Gly Tyr Val Lys Ser Asn Ser
 1               5                  10                  15      
Leu Leu Ser Ser Asn Cys Ser Thr Trp Lys Tyr Phe Ile Cys Glu Lys
            20                  25                  30          
Tyr
    


<210> 1484
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1484
Arg Ser Gln Ala Asn Gly Ala Gly Ala Leu Ser Tyr Val Ser Pro Asn
 1               5                  10                  15      
Thr Ser Lys Cys
            20  


<210> 1485
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1485
Arg Ser Pro Tyr Asn Ser His Met Gly Asn Asn Ala Ser Arg Pro His
 1               5                  10                  15      
Ser Ala Asn Gly Glu Val Tyr Gly Leu Leu Gly Ser Val Leu Thr Ile
            20                  25                  30          
Lys Lys Glu
        35  


<210> 1486
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1486
Arg Ser Pro Thr Gln Gly Tyr Arg Val Thr Pro Asp Ala Val His Ser
 1               5                  10                  15      
Val Gly Gly Asn Ser Ser Gln Ser Ser Ser Pro
            20                  25          


<210> 1487
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1487
Arg Ser Pro Ser Pro Ser Lys Asn Asp Ser Phe Phe Thr Pro Asp Ser
 1               5                  10                  15      
Asn His Asn Ser Leu Ser Gln Ser Thr Thr Gly His Leu Ser Leu Pro
            20                  25                  30          
Gln Lys Gln
        35  


<210> 1488
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1488
Arg Ser Pro Leu Gln Ala Cys Glu Asn Leu Ala Met Asn Glu Gly Gly
 1               5                  10                  15      
Pro Pro Thr Glu Asn Asn Ser Leu Ile Leu Glu Glu Asn Lys Ile
            20                  25                  30      


<210> 1489
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1489
Arg Ser Pro Ala Ser Glu Arg Arg Pro Leu Gly Asn Phe Thr Ala Pro
 1               5                  10                  15      
Pro Thr Tyr Thr Glu Thr Leu Ser Thr Ala Pro Leu Ala Ser Trp Val
            20                  25                  30          
Arg Ser
        


<210> 1490
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1490
Arg Ser Asn Thr Glu Asn Leu Ser Gln His Phe Arg Lys
 1               5                  10              


<210> 1491
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1491
Arg Ser Leu Thr Tyr Leu Ser Ile Asn Cys Thr Ser Ile Ser Leu Asn
 1               5                  10                  15      
Met Phe Ser Leu Leu His Asp Ile Leu His Glu Pro
            20                  25              


<210> 1492
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1492
Arg Ser Leu Ser Thr Pro Asn Ala Leu Ser Phe Gly Ser Pro Thr Ser
 1               5                  10                  15      
Ser Asp Asp Met Thr Leu Thr Ser Pro Ser Met Asp Asn Ser Ser Ala
            20                  25                  30          
Glu Leu
        


<210> 1493
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1493
Arg Ser Leu Cys Cys Gly Asp Ile Ser Gln Ser Ala Val Leu Phe Leu
 1               5                  10                  15      
Cys Gln Gly Thr Leu Ala Met Leu Asp Trp Gln Asn Gly Ser Met Gly
            20                  25                  30          
Arg Ser
        


<210> 1494
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1494
Arg Ser Leu Ala Glu Ala Asn Asn Leu Ser Phe Pro Leu Glu Pro Leu
 1               5                  10                  15      
Ser Arg Glu
            


<210> 1495
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1495
Arg Ser Lys Gly Ala Ile Ala Pro Pro Glu Val Thr Val Pro Ala Gln
 1               5                  10                  15      
Asn Thr Ser Leu Gly Pro Lys Lys
            20                  


<210> 1496
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1496
Arg Ser Ile Thr Lys Asn Pro Lys Ile Gly Gly Leu Pro Leu Ile Pro
 1               5                  10                  15      
Ile Gln His Glu Gly Asn Ala Thr Leu Ala Arg Lys
            20                  25              


<210> 1497
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1497
Arg Ser Ile Gln Lys Leu Gly Glu Leu Asn Ile Gly Met Asp Gly Leu
 1               5                  10                  15      
Gly Asn Glu Val Ser Ala Leu Asn Gln Gln Cys Asn Gly Ser Lys Gly
            20                  25                  30          


<210> 1498
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1498
Arg Ser His Asn Ala Ser Leu His Pro Thr Pro Glu Gln Cys Glu Ala
 1               5                  10                  15      
Val Ser Lys Phe Ile Gly Glu Cys Lys Ile
            20                  25      


<210> 1499
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1499
Arg Ser Phe Ser Cys Leu Asn Arg Ser Leu Ser Ser Gly Glu Ser Leu
 1               5                  10                  15      
Pro Gly Ser Pro Thr His Ser Leu Ser Pro Arg Ser
            20                  25              


<210> 1500
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1500
Arg Ser Phe Cys Lys Asp Gln Gln Gly Asp His Asn Gly Glu Asn Ser
 1               5                  10                  15      
Ser Lys Cys
            


<210> 1501
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1501
Arg Ser Glu Ala Ser Asn Gly Ser Thr Val Ala Ala Gly Thr Ser Lys
 1               5                  10                  15      
Ser Glu Glu Gly Leu Ser Ser Gly Leu Gly Ser Gly Val Gly Gly Lys
            20                  25                  30          
Pro
    


<210> 1502
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1502
Arg Ser Cys Asn Asp Phe Gly Ser Tyr Asn Asn Gln Ser Ser Asn Phe
 1               5                  10                  15      
Gly Pro Met Lys Ala
            20      


<210> 1503
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1503
Arg Ser Ala Ser Leu Ser Ser Leu Leu Ile Thr Pro Phe Pro Ser Pro
 1               5                  10                  15      
Asn Ser Ser Leu Thr Arg Ser Cys Ala Ser Ser Tyr Gln Arg Arg
            20                  25                  30      


<210> 1504
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1504
Arg Ser Ala Asn Leu Thr Asp Gln Pro Ser Trp Asn
 1               5                  10          


<210> 1505
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1505
Arg Arg Thr Ser Met His Ser Ser Leu Asn Thr Ser Pro Asn Gln Gln
 1               5                  10                  15      
Pro Asp Thr
            


<210> 1506
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1506
Arg Arg Thr Pro Glu Glu Ala Ala Ala Gly Glu Val Asn Leu Ser Ser
 1               5                  10                  15      


<210> 1507
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1507
Arg Arg Ser Ser Glu Asn Met Thr Ala Glu Pro Met Ser Glu Ser Lys
 1               5                  10                  15      
Leu Asn Thr Leu Val Gln Lys Leu
            20                  


<210> 1508
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1508
Arg Arg Ser Asn Val Ser Ser Pro Ala Thr Pro Thr Ala Ser Ser Ser
 1               5                  10                  15      
Ser Ser Thr Thr Pro Thr Arg Lys
            20                  


<210> 1509
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1509
Arg Arg Arg Lys Asn Met Ser Glu Phe Leu Gly Glu Ala Ser Ile Pro
 1               5                  10                  15      
Gly Gln Glu Pro Pro Thr
            20          


<210> 1510
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1510
Arg Arg Arg Ile Asn Ser Ser Val Thr Thr Glu Thr Ile Ser Glu Thr
 1               5                  10                  15      
Thr Glu Val Leu Asn Glu Pro Phe Asp Asn
            20                  25      


<210> 1511
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1511
Arg Arg Gln Ala Val Glu Leu Asn Val Val Ala Ile Val Asn Asp Thr
 1               5                  10                  15      
Val Gly Thr
            


<210> 1512
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1512
Arg Arg Pro Leu Val Leu Gln Leu Val Asn Ala Thr Thr Glu Tyr Ala
 1               5                  10                  15      
Glu Phe Leu His Cys Lys Gly
            20              


<210> 1513
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1513
Arg Arg Pro Ala Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr
 1               5                  10                  15      
Cys Tyr Val Asn Ala Ser Leu Gln Cys Leu
            20                  25      


<210> 1514
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1514
Arg Arg Pro Ala Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr
 1               5                  10                  15      
Cys Tyr Glu Asn Ala Ser Leu Gln Cys Leu Thr
            20                  25          


<210> 1515
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1515
Arg Arg Asn Ala Glu Trp His Val His Met Met Glu Tyr Tyr Ala Ala
 1               5                  10                  15      
Glu Asn Met Asn Asn Trp Ser His Gly Met Asn Glu Ala Glu Arg Phe
            20                  25                  30          


<210> 1516
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1516
Arg Arg Asn Thr Ser Gly Thr Pro Ser Ile Ala Val Ser Gly Thr Ser
 1               5                  10                  15      
Leu Ser Ser Asp Gln Ser Arg Ser
            20                  


<210> 1517
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1517
Arg Arg Asn Ala Ser Gly Leu Thr Asn Gly Leu Ser Ser Gln Glu Arg
 1               5                  10                  15      
Pro
    


<210> 1518
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1518
Arg Arg Met Glu Ser Asn Thr Ser Ser Ser Leu Glu Asn Leu Ala Thr
 1               5                  10                  15      
Ala Pro Val
            


<210> 1519
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1519
Arg Arg Leu Trp Gln Gly Leu Gly Asn Phe Ser Val Asn Thr Ser Lys
 1               5                  10                  15      
Gly Asn Thr Ala Lys Asn Gly Gly Leu Leu Leu Ser Thr Asn Met Lys
            20                  25                  30          
Trp
    


<210> 1520
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1520
Arg Arg Leu Thr Ile Glu Gly Val Leu Asp His Pro Trp Leu Asn Ser
 1               5                  10                  15      
Thr Glu Ala Leu Asp Asn Val Leu Pro Ser Ala Gln Leu Met Met Asp
            20                  25                  30          
Lys Ala
        


<210> 1521
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1521
Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp Leu Glu Ala
 1               5                  10                  15      
Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg Ser
            20                  25                  30  


<210> 1522
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1522
Arg Arg Leu Arg Ile His Asn Leu Gly Leu Asn Cys Ser Ser Gln Leu
 1               5                  10                  15      
Ala Asp Leu Tyr Lys Ser Cys Glu
            20                  


<210> 1523
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1523
Arg Arg Leu Arg Glu Leu Ala Gly Asn Ser Ser Thr Pro Pro Pro Val
 1               5                  10                  15      
Ser Pro Gly Arg Gly Asn Pro Met His Arg Leu Leu Asn Pro Phe
            20                  25                  30      


<210> 1524
<211> 30
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = Any Amino Acid

<400> 1524
Arg Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Xaa Leu Val Ser Val
 1               5                  10                  15      
Gly Ala Asn Ser Ala Val Asn Asn Thr Ala Glu Ser Lys Met
            20                  25                  30  


<210> 1525
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1525
Arg Arg Ile Asn Met Ser Phe Val Glu Val Lys Asp Lys Lys
 1               5                  10                  


<210> 1526
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1526
Arg Arg His Lys Asp Met Asp Val Asp Ile Leu Ala Leu Val Asn Asp
 1               5                  10                  15      
Thr Val Gly Thr Met Met Thr Cys Ala
            20                  25  


<210> 1527
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1527
Arg Arg Gly Gly Arg Phe Ser Ala Gln Gly Met Gly Thr Phe Asn Pro
 1               5                  10                  15      
Ala Asp Tyr Ala Glu Pro Ala Asn Thr Asp Asp Asn Tyr Gly Asn Ser
            20                  25                  30          
Ser Gly Asn Thr
        35      


<210> 1528
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1528
Arg Arg Glu Gln Met Ala Ala Ala Ala Ala Arg Pro Ile Asn Ala Ser
 1               5                  10                  15      
Met Lys Pro Gly Asn Val Gln Gln Ser Val Asn Arg Lys
            20                  25                  


<210> 1529
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1529
Arg Arg Asp Met Gly Asn Phe Ser Trp Gly Ser Glu Cys
 1               5                  10              


<210> 1530
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1530
Arg Arg Ala Arg His Asp Ser Pro Asp Pro Ser Pro Pro Arg Arg Pro
 1               5                  10                  15      
Gln His Asn Ser Ser Gly Asp Cys Gln Lys Ala
            20                  25          


<210> 1531
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1531
Arg Arg Ala Arg His Asp Ser Pro Asp Leu Ala Pro Asn Val Thr Tyr
 1               5                  10                  15      
Ser Leu Pro Arg Thr Lys Ser
            20              


<210> 1532
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1532
Arg Arg Ala Glu Met Ser Gln Thr Asn Phe Thr Pro Asp Thr Leu Ala
 1               5                  10                  15      
Gln Asn Glu Gly Lys Ala
            20          


<210> 1533
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1533
Arg Arg Ala Glu Leu Val Cys Leu Asn Asn Thr Glu Ile Ser Glu Asn
 1               5                  10                  15      
Ser Ser Asp Leu Ser Gln Lys Leu Lys Glu
            20                  25      


<210> 1534
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1534
Arg Gln Tyr Lys Asp Leu Trp Asn Met Ser Asp Asp Lys Pro Phe Leu
 1               5                  10                  15      
Cys Thr Ala Pro Gly Cys Gly Gln Arg
            20                  25  


<210> 1535
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1535
Arg Gln Val Tyr Asn Ala Thr Ile Ala Glu His Ala Pro Val Gly His
 1               5                  10                  15      


<210> 1536
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1536
Arg Gln Ser Leu Thr Ser Pro Asp Ser Gln Ser Ala Arg Pro Ala Asn
 1               5                  10                  15      
Arg Thr Ala Leu Ser Asp Pro Ser Ser Arg Leu
            20                  25          


<210> 1537
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1537
Arg Gln Ser Lys Ser Glu Ser Asp Tyr Ser Asp Gly Asp Asn Asp Ser
 1               5                  10                  15      
Ile Asn Ser Thr Ser Asn Ser Asn Asp Thr Ile Asn Cys Ser Ser Glu
            20                  25                  30          
Ser Ser Ser Arg Asp
        35          


<210> 1538
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1538
Arg Gln Pro Pro Pro Pro Tyr Pro Leu Thr Ala Ala Asn Gly Gln Ser
 1               5                  10                  15      
Pro Ser Ala Leu Gln Thr Gly Gly Ser Ala Ala Pro Ser Ser Tyr Thr
            20                  25                  30          
Asn Gly Ser Ile Pro Gln
        35              


<210> 1539
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1539
Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly
 1               5                  10                  15      
Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp
            20                  25                  30  


<210> 1540
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1540
Arg Gln Asn Ser Ser Asp Ser Ile Ser Ser Leu Asn Ser Ile Thr Ser
 1               5                  10                  15      
His Ser Ser Ile Gly Ser Ser Lys Asp Ala Asp Ala Lys Lys
            20                  25                  30  


<210> 1541
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1541
Arg Gln Met Ser Gln Gln Asn Leu Thr Lys Gln
 1               5                  10      


<210> 1542
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1542
Arg Gln Leu Val Glu Met Glu Tyr Thr Met Gln Gln Cys Asn Ala Ser
 1               5                  10                  15      
Val Tyr Met Glu Ala Lys Asn Arg Gly
            20                  25  


<210> 1543
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1543
Arg Gln Leu Asn Thr Ser Asp Glu Asn Gly Lys Glu Glu Leu Phe Ser
 1               5                  10                  15      
Leu Lys Asp
            


<210> 1544
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1544
Arg Gln Leu Glu Asp Pro Asn Gly Ser Phe Ser Asn Ala Glu Met Ser
 1               5                  10                  15      
Glu Leu Ser Val Ala Gln Lys Pro Glu Lys Leu
            20                  25          


<210> 1545
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1545
Arg Gln Lys Glu Asn Asp Thr Gln Ile Phe Asn Asp Ser Ala Val Asp
 1               5                  10                  15      
Asn His Ser Lys Cys
            20      


<210> 1546
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1546
Arg Gln Ile Arg Glu Ile Leu Ala Lys Ser Asn Ala Ser Asn
 1               5                  10                  


<210> 1547
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1547
Arg Gln His Asn Asn Thr Gly Tyr Ile Tyr Ser Arg Asp Gln Trp Asp
 1               5                  10                  15      
Pro Glu Val Ile Glu Asn His Arg Lys Lys Lys
            20                  25          


<210> 1548
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1548
Arg Gln Gly Asn Leu Ser Leu Pro Leu Asn Arg Glu Leu Val Glu Lys
 1               5                  10                  15      
Val Thr Asn Glu Tyr Asn Glu Ser Leu Leu Tyr Ser Pro Glu Glu Pro
            20                  25                  30          
Lys Ile
        


<210> 1549
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1549
Arg Gln Phe Pro Lys Leu Asn Ile Ser Glu Val Asp Glu Gln Val Arg
 1               5                  10                  15      
Leu
    


<210> 1550
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1550
Arg Gln Phe Asn Gln Thr Val Gln Ser Ser Gly Asn Met Thr Asp Lys
 1               5                  10                  15      
Ser
    


<210> 1551
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1551
Arg Gln Asp Asn Gly Thr Leu Leu Ser Leu Glu Asp Leu Asn Gly Gly
 1               5                  10                  15      
Ile Leu Val Asp Val Asn Thr Ala Glu His Ser Thr Val
            20                  25                  


<210> 1552
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1552
Arg Pro Gln Ser Asn Ser Ser Ala Val Thr Gly Thr Ser Gly Ser Ile
 1               5                  10                  15      
Met Glu Asn Gly Val Ser Ser Ser Asn Thr Ala Asp Lys Ser
            20                  25                  30  


<210> 1553
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1553
Arg Asn Tyr Gln Arg Ile Glu Gln Asn Leu Thr Ser Thr Ala Ser Ser
 1               5                  10                  15      
Gly Thr Asn Val His Gly Ser Pro
            20                  


<210> 1554
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1554
Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu Ser Ser Ala Ser Arg Met
 1               5                  10                  15      
Gln Val Glu Gln Asn Leu Ser Asp His Ile
            20                  25      


<210> 1555
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1555
Arg Asn Ser Arg Met Asn Phe Thr Tyr Gln Ile Ala Asp Cys Asn Arg
 1               5                  10                  15      
Asp
    


<210> 1556
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1556
Arg Asn Ser Ile Asn Val Phe Ala Ser Pro Ala His Tyr Thr Ser Thr
 1               5                  10                  15      
Thr Gly Ser Cys Asn Phe Glu Thr Ser Ser Gly Asn Trp Thr Thr Ala
            20                  25                  30          
Cys
    


<210> 1557
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1557
Arg Asn Arg Asp Leu Asn Asn Ser Ser Ile Asn Leu Thr Lys Val Lys
 1               5                  10                  15      
Ile
    


<210> 1558
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1558
Arg Asn Gln Gln Thr Ile Leu Gly Ser Pro Ala Ser Gly Ile Gln Asn
 1               5                  10                  15      
Thr Ile Gly Ser Val Gly Thr Gly Gln Gln Asn Ala Thr Ser
            20                  25                  30  


<210> 1559
<211> 39
<212> PRT
<213> Homo sapiens

<400> 1559
Arg Asn Pro Phe His His Ser Leu Pro Phe Ser Ile Pro Val His Phe
 1               5                  10                  15      
Thr Asn Gly Thr Tyr His Val Val Gly Phe Asp Gly Ser Ser Thr Val
            20                  25                  30          
Asp Glu Phe Leu Gln Arg Leu
        35                  


<210> 1560
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1560
Arg Asn Pro Ala Asp Gly Ile Pro Ala Pro Glu Ser Ser Ser Asp Ser
 1               5                  10                  15      
Asp Ser His Glu Ser Ser Leu Ala Gln Lys Trp Asn Met Thr Gly Arg
            20                  25                  30          
Ser
    


<210> 1561
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1561
Arg Asn Met Tyr Thr Val Gln Asn Asn Ser Gly Pro Tyr Phe Asn Pro
 1               5                  10                  15      
Arg Ser
        


<210> 1562
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1562
Arg Asn Leu Asn Gly Thr Leu His Glu Leu Leu Arg Met Asn Ile Val
 1               5                  10                  15      
Pro Ile Val Asn Thr Asn Asp Ala Val Val Pro
            20                  25          


<210> 1563
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1563
Arg Asn Leu Asn Asp Ser Ser Leu Phe Val Ser Ala Glu Glu Phe Gly
 1               5                  10                  15      
His Leu Leu Asp Glu Asn Met Gly Ser Lys Phe
            20                  25          


<210> 1564
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1564
Arg Asn Leu Phe Asn Gln Trp Lys Gln Asn Ala Thr Asp Ile Met Glu
 1               5                  10                  15      
Ala Met Leu Lys Arg
            20      


<210> 1565
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1565
Arg Asn Leu Ala Met Glu Ala Thr Tyr Ile Asn His Asn Phe Ser Gln
 1               5                  10                  15      
Gln Cys Leu Arg Met
            20      


<210> 1566
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1566
Arg Asn Lys Glu Ser Ser Asp Gln Thr Gly Ile Asn Ile Ser Gly Phe
 1               5                  10                  15      
Glu Asn Lys Ile
            20  


<210> 1567
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1567
Arg Asn Ile Asn Gly Leu Phe Leu Pro Pro Ser Ser Asn Ile Thr Leu
 1               5                  10                  15      
Gln Lys Glu
            


<210> 1568
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1568
Arg Asn His Glu Thr Thr Asn Leu Ser Ile Gln Gln Lys Arg
 1               5                  10                  


<210> 1569
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1569
Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp Val
 1               5                  10                  15      
Phe Val His Gln Thr Ala Ile Lys Lys
            20                  25  


<210> 1570
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1570
Arg Asn Gly Lys Pro Glu Asn Asn Thr Met Asn Ile Asn Ala Ser Ile
 1               5                  10                  15      
Tyr Asp Glu Ile Gln Gln Glu Met Lys Arg
            20                  25      


<210> 1571
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1571
Arg Asn Gly Gly Thr Asn Glu Glu Ser Asn Ser Ser Gly Asn Thr Asn
 1               5                  10                  15      
Thr Asp Pro Pro Ala Glu Asp Ser Gln Lys Ser
            20                  25          


<210> 1572
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1572
Arg Asn Gly Glu Ser Met Leu Asn Ala Ser Leu Val Asn Ala Ser Ser
 1               5                  10                  15      
Leu Ser Glu Ala Glu Gln Leu Gln Arg Glu
            20                  25      


<210> 1573
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1573
Arg Asn Gly Asp Pro Ser Thr Trp Val Lys Asn Ser Thr Ala Leu Ile
 1               5                  10                  15      
Ser Thr Ile Pro Gly Thr Tyr Val Gly Val Ala Asn
            20                  25              


<210> 1574
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1574
Arg Asn Phe Asn Tyr His Ile Leu Ser Pro Cys Asp Leu Ser Asn Tyr
 1               5                  10                  15      
Thr Asp Leu Ala Met Ser Thr Val Lys Gln
            20                  25      


<210> 1575
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1575
Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe Ile Phe Asn
 1               5                  10                  15      
Leu Tyr Ser Glu Glu Gly Lys Gly
            20                  


<210> 1576
<211> 39
<212> PRT
<213> Homo sapiens

<400> 1576
Arg Asn Asp Met Thr Tyr Asn Tyr Ala Asn Arg Gln Ser Thr Gly Ser
 1               5                  10                  15      
Ala Pro Gln Gly Pro Ala Tyr His Gly Val Asn Arg Thr Asp Glu Val
            20                  25                  30          
Leu His Thr Asp Gln Arg Ala
        35                  


<210> 1577
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1577
Arg Asn Cys Gln Ala Ile Gln Gln Asn His Ser Cys Ser Lys Ser
 1               5                  10                  15  


<210> 1578
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1578
Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln Ala
 1               5                  10                  15      
Ile Glu Ser
            


<210> 1579
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1579
Arg Asn Tyr Ser Ser Ile His Ser Gln Ser Arg Ser Thr Ser
 1               5                  10                  


<210> 1580
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1580
Arg Asn Ser Thr Glu Leu Ser Glu Met Phe Pro Val Leu Pro Gly Ser
 1               5                  10                  15      
His Leu
        


<210> 1581
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1581
Arg Asn Ser Thr Asp Glu Asn Phe His Ala Ser Leu Met Ser Glu Ile
 1               5                  10                  15      
Ser Pro Ile Ser Thr Ser Pro Glu Ile Ser Glu Ala Ser Leu Met Ser
            20                  25                  30          
Asn Leu Pro Leu
        35      


<210> 1582
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1582
Arg Asn Ser Ser Leu Val Leu His His Arg Thr
 1               5                  10      


<210> 1583
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1583
Arg Asn Ser Ser Leu Leu Glu Pro Gln Lys Ser Gly Asn Asn Glu Thr
 1               5                  10                  15      


<210> 1584
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1584
Arg Asn Arg Ser Phe Gln Pro Gly Leu Asp Asn Ile Ile Phe Val Val
 1               5                  10                  15      
Glu Thr Gly Pro Leu Pro
            20          


<210> 1585
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1585
Arg Asn Pro Ser Ser Ala Ala Pro Val Gln Ser Arg Gly Gly Ile Gly
 1               5                  10                  15      
Ala Ser Glu Asn Leu Glu Asn Pro Pro Lys Met Gly Glu Glu Glu Ala
            20                  25                  30          


<210> 1586
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1586
Arg Asn Pro Ser Gln Leu Pro Ala Leu Ser Ser Ser Pro Ala His Ser
 1               5                  10                  15      
Gly Met Met Gly Ile Asn Ser Tyr Gly Ser Gln Leu Gly Val Ser Ile
            20                  25                  30          
Ser
    


<210> 1587
<211> 41
<212> PRT
<213> Homo sapiens

<400> 1587
Arg Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp
 1               5                  10                  15      
Glu Ser Ala Ser Gly Asn Gly Phe Asn Gly Gly Ser Gly Ser Ser Met
            20                  25                  30          
Asp Ser Gln Ser Ser Gly Trp Glu Met
        35                  40      


<210> 1588
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1588
Arg Asn Met Thr Leu Leu Ala Thr Ile Met Ser Gly Ser Thr Met Ser
 1               5                  10                  15      
Leu Asn His Glu Ala
            20      


<210> 1589
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1589
Arg Asn Leu Thr Ala Leu Gly Leu Asn Leu Val Ala Ser Gly Gly Thr
 1               5                  10                  15      
Ala Lys Ala Leu Arg Asp
            20          


<210> 1590
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1590
Arg Asn Leu Thr Ala Gly Met Ala Met Ser Thr Cys Arg Glu
 1               5                  10                  


<210> 1591
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1591
Arg Asn Leu Ser Leu Gln Val Ala Phe Ser Gly Ala Thr Ala Cys Met
 1               5                  10                  15      
Ala His Val Asp Gly Ile His Leu His Val Ala Asn Ala Gly Asp Cys
            20                  25                  30          
Arg Ala
        


<210> 1592
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1592
Arg Asn Ile Thr Ile Met Ala Ser Gly Asn Thr Gly Gly Glu Lys Asp
 1               5                  10                  15      


<210> 1593
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1593
Arg Asn Phe Ser Leu Pro Asp Ile Cys Glu Glu Asp Pro Gly Ala Pro
 1               5                  10                  15      
Ala Gly Ala Val Glu Leu Pro Gly Ala Trp Val Pro Gly Ala Gly Gln
            20                  25                  30          
Arg His
        


<210> 1594
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1594
Arg Asn Cys Thr Ile Val Ser Pro Asp Ala Gly Gly Ala Lys Arg Val
 1               5                  10                  15      
Thr
    


<210> 1595
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1595
Arg Met Thr Gln Pro Met Met Asn Ser Ser Tyr His Ser Asn Pro Ala
 1               5                  10                  15      
Tyr Met Asn Gln Thr Ala Gln Tyr Pro Met Gln Met Gln
            20                  25                  


<210> 1596
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1596
Arg Met Gln Ser Pro Gln Asn Leu His Gly Gln Gln Asp Asp Asp Ser
 1               5                  10                  15      
Ala Ala Glu Ser Phe Asn Gly Asn Glu Thr Leu
            20                  25          


<210> 1597
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1597
Arg Met Ile Glu Gln Tyr His Asn His Ser Asp His Tyr Cys Leu Asn
 1               5                  10                  15      
Leu Asp Ser Gly Met Val Ile Asp Ser Tyr Arg Met
            20                  25              


<210> 1598
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1598
Arg Met Glu Asn Ala Asn Leu Pro Thr Lys Gln Glu Pro Ser Trp Ile
 1               5                  10                  15      
Asn Gln Ser Glu Gln Gly Ile Lys Glu
            20                  25  


<210> 1599
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1599
Arg Met Asp Asp Val Pro Ser His Ser Lys Ala Leu Ser Asp Gly Asn
 1               5                  10                  15      
Gly Ser Ser Gly Ile Glu Trp Ser Asn
            20                  25  


<210> 1600
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1600
Arg Leu Tyr Gln Gln Phe Asn Glu Asn Asn Ser Ile Gly Glu Thr Gln
 1               5                  10                  15      
Ala Arg Lys Leu Ser Lys Leu
            20              


<210> 1601
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1601
Arg Leu Val Lys Val Lys Asn Glu Gly Asp Asp Phe Gly Trp Gly Val
 1               5                  10                  15      
Val Val Asn Phe Ser Lys Lys Ser
            20                  


<210> 1602
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1602
Arg Leu Ser Ser Ser Gly Ser Asn Cys Ser Ser Gly Ser Glu Gly Glu
 1               5                  10                  15      
Pro Val Ala Leu His Ala Gly Ile Cys Val Arg Gln
            20                  25              


<210> 1603
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1603
Arg Leu Ser Gln Asn Gln Asn Asn Tyr Gln Ile Ser Gly Asn Leu Thr
 1               5                  10                  15      
Val Pro Trp Ile Thr Gly Cys Ser Arg Lys
            20                  25      


<210> 1604
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1604
Arg Leu Ser Asn Gly Ser Ile Asp Ser
 1               5                  


<210> 1605
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1605
Arg Leu Arg Asn Ser Ser Ser Phe Ser Met Asp Asp Pro Asp Ala Gly
 1               5                  10                  15      
Ala Met Gly Ala Ala Ala Ala Glu Gly Gln Ala
            20                  25          


<210> 1606
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1606
Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu Leu Lys
 1               5                  10                  15      
His Glu Asn Lys Ser
            20      


<210> 1607
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1607
Arg Leu Pro Asn Thr Tyr Pro Asn Ser Ser Ser Pro Gly Pro Gly Gly
 1               5                  10                  15      
Leu Gly Gly Ser Val His Tyr Ala Thr Met Ala Arg Ser Ala Val Arg
            20                  25                  30          
Pro Ala Ser
        35  


<210> 1608
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1608
Arg Leu Pro Leu Ala Asn Met Ser Tyr Tyr Val Ser Pro Gln Ala Val
 1               5                  10                  15      
Asp Ala Val His Arg Gly Leu Gly Leu Pro Leu Pro Arg Thr
            20                  25                  30  


<210> 1609
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1609
Arg Leu Asn Tyr Leu Leu Arg Val Asn Gly Ser Glu Gln Thr Val Val
 1               5                  10                  15      
Ala Phe Phe Ile Met Pro Ala Arg Thr Asn Asn Phe Asn Val
            20                  25                  30  


<210> 1610
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1610
Arg Leu Asn Thr Thr Asn Ala Trp Asp Ala Ala Pro Pro Ser Leu Gly
 1               5                  10                  15      
Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His
            20                  25          


<210> 1611
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1611
Arg Leu Asn Ser Ser Ser Val Ser Asn Leu Ala Ala Val Gly Asp Leu
 1               5                  10                  15      
Leu His Ser Ser Gln Ala Ser Leu Thr Ala Ala Leu Gly Leu Arg Pro
            20                  25                  30          


<210> 1612
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1612
Arg Leu Asn Met Thr Thr Glu Gln Phe Thr Gly Asp His Thr Gln His
 1               5                  10                  15      
Phe Leu Asp Gly Gly Glu Met
            20              


<210> 1613
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1613
Arg Leu Asn Gly Ser Ala Ala Gly His Val Leu
 1               5                  10      


<210> 1614
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1614
Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn Gly Glu Asp Val
 1               5                  10                  15      
Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu Lys Cys
            20                  25                  30  


<210> 1615
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1615
Arg Leu Met Leu Pro Asp Asp Thr Thr Asn His Ser Asn Ser Ser Lys
 1               5                  10                  15      
Glu
    


<210> 1616
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1616
Arg Leu Met Ala Phe Gly Cys Val Ser Gly Ser Val Gln Val Tyr Thr
 1               5                  10                  15      
Ile Asp Asn Ser Thr Gly Ala Met Leu Leu Ser His Lys Leu
            20                  25                  30  


<210> 1617
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1617
Arg Leu Leu Thr Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp Ile
 1               5                  10                  15      
Leu Ser Ser Ala Cys Tyr Thr Val Arg Asn
            20                  25      


<210> 1618
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1618
Arg Leu Leu Ser Asn Pro Leu Leu Gln Thr Tyr Leu Pro Asn Ser Thr
 1               5                  10                  15      
Lys Lys
        


<210> 1619
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1619
Arg Leu Leu Gln Met Pro Ser Val Val Asn Tyr Ser Gly Leu Arg Lys
 1               5                  10                  15      
Arg
    


<210> 1620
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1620
Arg Leu Leu Asn Leu Ser Phe Cys Gly Gly Ile Ser Asp Ala Gly Leu
 1               5                  10                  15      
Leu His Leu Ser His Met Gly Ser Leu Arg Ser Leu Asn Leu Arg Ser
            20                  25                  30          


<210> 1621
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1621
Arg Leu Leu Gly His Ser Pro Val Leu Arg Asn Ile Thr Asn Ser Gln
 1               5                  10                  15      
Ala Pro Asp Gly Arg Arg Lys
            20              


<210> 1622
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1622
Arg Leu Leu Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val
 1               5                  10                  15      
Ser Ser Ile Asn Arg Ile
            20          


<210> 1623
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1623
Arg Leu Lys Tyr Gln Ala Gln Asn Ile Thr Ser Gly Asp Thr Thr Thr
 1               5                  10                  15      
Ile Leu Pro Ala Ala Cys Cys Thr Met Lys Ser
            20                  25          


<210> 1624
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1624
Arg Leu Ile Asn Leu Tyr Ile Ile Gln Asn Asn Ser Phe Ser Gln
 1               5                  10                  15  


<210> 1625
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1625
Arg Leu Gly Thr Phe Thr Thr Gln Asn Ala Ser Ala Pro Arg Asn Pro
 1               5                  10                  15      
Glu Thr Pro Gly Ser Pro Val Pro Pro Ser Gly Arg Pro
            20                  25                  


<210> 1626
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1626
Arg Leu Gly Ser Thr Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser
 1               5                  10                  15      
Ser Pro Leu Val Gly Pro Glu Cys Asp His Pro Lys Ile
            20                  25                  


<210> 1627
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1627
Arg Leu Gly Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser Ser Leu Gly
 1               5                  10                  15      
Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro
            20                  25          


<210> 1628
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1628
Arg Leu Gly Pro Val Ser Thr Ala Asn Met Ser Arg Pro
 1               5                  10              


<210> 1629
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1629
Arg Leu Gly Lys Pro Ser Val Met Thr Pro Thr Glu Gly Leu Asp Thr
 1               5                  10                  15      
Gly Glu Met Ser Asn Ser Thr Ser Ser Leu Lys Arg
            20                  25              


<210> 1630
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1630
Arg Leu Glu Ser Gly Met Arg Asn Met Ser Ile His Ser Lys Thr
 1               5                  10                  15  


<210> 1631
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1631
Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val Ser
 1               5                  10                  15      
Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala
            20                  25              


<210> 1632
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1632
Arg Leu Glu Cys Asn Gly Thr Ile Ser Ala His Cys Asn Leu His Leu
 1               5                  10                  15      
Pro Gly Ser Ser Asp Ser Pro Ala Ser Ser Ser Arg Val Ala Gly Ile
            20                  25                  30          
Thr Gly Ile Lys Thr
        35          


<210> 1633
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1633
Arg Leu Asp Asn Ile Thr Gln Val Met Ser Leu His Thr Gln Tyr Leu
 1               5                  10                  15      
Glu Ser Phe Leu Arg Ser
            20          


<210> 1634
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1634
Arg Leu Ala Met Ala Tyr Gly Leu Asn Val Ser Phe Leu Glu Arg Leu
 1               5                  10                  15      


<210> 1635
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1635
Arg Lys Tyr Gly Ser Cys Ser Thr Ile Leu Leu Asp Asn Ser Thr Ala
 1               5                  10                  15      
Ser Gln Pro Asp Leu Arg His
            20              


<210> 1636
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1636
Arg Lys Thr Asp Asn Gly Thr Glu Ala Trp Gly Ser Ser Ala Thr Gln
 1               5                  10                  15      
Thr Phe Asn Ser Gly Ala Cys Ile Asp Lys Thr
            20                  25          


<210> 1637
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1637
Arg Lys Ser Glu Ile His Gly Ala Pro Val Leu Phe Gln Asn Leu Ser
 1               5                  10                  15      
Gly Val His Trp Gly Tyr Glu Glu Thr Lys Thr
            20                  25          


<210> 1638
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1638
Arg Lys Arg Asn Val Asp Ser Ser Gly Asn Lys Ser Val Leu Met Glu
 1               5                  10                  15      
Arg Leu Lys
            


<210> 1639
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1639
Arg Lys Gln Glu Glu Phe Asp Val Ala Asn Asn Gly Ser Ser Gln Ala
 1               5                  10                  15      
Asn Lys Leu
            


<210> 1640
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1640
Arg Lys Pro Ser Pro Gln Asp Ile Ala Gln Ala Val Leu Arg Asn Phe
 1               5                  10                  15      
Ser Gly Lys Asp
            20  


<210> 1641
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1641
Arg Lys Pro Pro Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His
 1               5                  10                  15      
Ile Ala Gln Asn Asp Ser Pro Thr Leu Gln Ser Asn Glu Trp Thr Asp
            20                  25                  30          
Ser Phe Arg Arg
        35      


<210> 1642
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1642
Arg Lys Asn Lys Pro Leu Ser Asp Met Glu Leu Asn Ser Ser Ser Glu
 1               5                  10                  15      
Asp Ser Lys Gly
            20  


<210> 1643
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1643
Arg Lys Asn Tyr Thr Ser Thr Glu Leu Thr Val Glu Pro Glu Glu Pro
 1               5                  10                  15      
Ser Asp Ser Ser Gly Ile Asn Leu Ser Gly Phe Gly Arg Asn
            20                  25                  30  


<210> 1644
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1644
Arg Lys Asn Ser Thr Phe Pro Gln Val Gln Met Arg
 1               5                  10          


<210> 1645
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1645
Arg Lys Asn Ile Thr Asn Asp Ile Arg Thr
 1               5                  10  


<210> 1646
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1646
Arg Lys Asn Cys Ser Gln Ile Ala Leu Phe Gln Lys Arg
 1               5                  10              


<210> 1647
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1647
Arg Lys Asn Ala Ser Ala Leu Tyr Glu Lys Ile Arg Gly
 1               5                  10              


<210> 1648
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1648
Arg Lys Met Pro Ser Asn Gln Asn Val Ser Pro Ser Gln Arg Asp
 1               5                  10                  15  


<210> 1649
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1649
Arg Lys Met Leu Leu Trp Ala Met Ser Val Thr Leu Glu Gln Asn Leu
 1               5                  10                  15      
Thr Cys Pro Gly Ser Asp Leu Lys Pro Phe Thr Thr Arg Leu
            20                  25                  30  


<210> 1650
<211> 43
<212> PRT
<213> Homo sapiens

<400> 1650
Arg Lys Met Ala His Pro Ala Met Phe Pro Arg Arg Gly Ser Gly Ser
 1               5                  10                  15      
Gly Ser Ala Ser Ala Leu Asn Ala Ala Gly Thr Gly Val Gly Ser Asn
            20                  25                  30          
Ala Thr Ser Ser Glu Asp Phe Pro Pro Pro Ser
        35                  40              


<210> 1651
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1651
Arg Lys Leu Gln Gly Asn Met Leu Leu Asn Ser Ser Met Glu Asp Lys
 1               5                  10                  15      
Met Leu Lys Glu Asn Pro Glu Glu Lys Leu
            20                  25      


<210> 1652
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1652
Arg Lys Leu Asn Pro Ser Gln Asn Ala Thr Gly Thr Ser Arg Ser Glu
 1               5                  10                  15      


<210> 1653
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1653
Arg Lys Leu Gly Tyr Ser Ser Leu Ile Leu Asp Ser Thr Gly Ser Thr
 1               5                  10                  15      
Leu Phe Ala Asn Cys Thr Asp Asp Asn Ile Tyr Met Phe Asn Met Thr
            20                  25                  30          
Gly
    


<210> 1654
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1654
Arg Lys Leu Phe Gln Glu Ile Leu Asn Thr Ser Arg Glu
 1               5                  10              


<210> 1655
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1655
Arg Lys Lys Val Thr Ala Gln Asn Leu Ser Asp Gly Asp Ile Lys Leu
 1               5                  10                  15      
Leu Val Asn Ile Val Arg Ala Tyr Asp Ile Pro Val Arg Lys
            20                  25                  30  


<210> 1656
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1656
Arg Lys Lys Asn Leu Thr Leu Ala Leu Glu Ala Leu Val Gln Leu Arg
 1               5                  10                  15      
Gly
    


<210> 1657
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1657
Arg Lys Lys Leu Ile Asn Gly Thr Gly Leu Ser Ala Val Lys Pro
 1               5                  10                  15  


<210> 1658
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1658
Arg Lys Phe Ser Phe Tyr Gly Asn Leu Ser Pro Arg Arg Ser
 1               5                  10                  


<210> 1659
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1659
Arg Lys Phe Lys Thr Asn Val Leu Pro Phe Arg Gln Asn Asp Ser Ser
 1               5                  10                  15      
Ser His Cys Gln Lys Ser Gly Ser Pro Ile Ser Ser Glu Glu Arg Arg
            20                  25                  30          
Arg
    


<210> 1660
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1660
Arg Lys Glu Asn Ser Phe Leu Thr His Gln His Gly Asn Asp Ser Glu
 1               5                  10                  15      
Ala Glu Gly Glu Val Val Cys Arg Leu
            20                  25  


<210> 1661
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1661
Arg Lys Glu Gly Asn Phe Ser Asp Leu Lys Glu
 1               5                  10      


<210> 1662
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1662
Arg Lys Asp Glu Asn Glu Ser Ser Ala Pro Ala Asp Gly Glu Gly Gly
 1               5                  10                  15      
Ser Glu Leu Gln Pro Lys Asn
            20              


<210> 1663
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1663
Arg Lys Ala Cys Lys Asn Cys Thr Cys Gly Leu Ala Glu Glu Leu Glu
 1               5                  10                  15      
Lys Glu
        


<210> 1664
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1664
Arg Lys Ala Ala Ser Thr Leu Ser Asp Thr Lys Asn Met Glu Ile Ile
 1               5                  10                  15      
Asn Ser Thr Ile Glu Thr Leu Ala Pro Asp Ser Pro Phe Asp His Lys
            20                  25                  30          


<210> 1665
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1665
Arg Ile Val Thr Thr Asn Val Thr Met Pro Glu Gly Pro Pro Gln Asn
 1               5                  10                  15      
Cys Val Thr Gly Asn Ile Thr Gly Lys Ser
            20                  25      


<210> 1666
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1666
Arg Ile Val Asn Asp Thr Tyr Arg Thr
 1               5                  


<210> 1667
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1667
Arg Ile Ser Lys Leu Ile Asn Ser Ser Asp Glu Leu Gln Asp Asn Phe
 1               5                  10                  15      
Arg Glu
        


<210> 1668
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1668
Arg Ile Ser Cys Arg Pro Gln Thr Gln Ile Ser Asn Asn Tyr Gly Asn
 1               5                  10                  15      
Asn Pro Leu Asn Ser Ser Leu Leu Pro Gln Lys Gln
            20                  25              


<210> 1669
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1669
Arg Ile Arg Val Asp Leu Pro Leu Gly Ser Pro Ala Val Asn Cys Thr
 1               5                  10                  15      
Val Leu Pro Gly Gly Ile Ser Val
            20                  


<210> 1670
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1670
Arg Ile Arg Thr Tyr Asn Phe Thr Gln Asp Arg Val Ser Asp His Arg
 1               5                  10                  15      
Ile Ala Tyr Glu Val Arg Asp
            20              


<210> 1671
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1671
Arg Ile Pro Arg Ala Asp Glu Leu Asn Gln Thr Gly Gln Ile Leu Val
 1               5                  10                  15      
Glu Gln Met Gly Lys Glu
            20          


<210> 1672
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1672
Arg Ile Asn Glu Val Gln Val Asn Leu Ser Leu Leu Gly Asp Asp Leu
 1               5                  10                  15      
Leu Leu Pro Ala Gln Ser Thr Leu Gln Thr Lys His
            20                  25              


<210> 1673
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1673
Arg Ile Leu Thr Asn Phe Thr Gly Val Met Pro Pro Gln Phe Lys Lys
 1               5                  10                  15      


<210> 1674
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1674
Arg Ile Leu Lys Val Ala Glu Phe Phe Asn Tyr Ser Lys Asn Arg Ile
 1               5                  10                  15      


<210> 1675
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1675
Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Gly Phe Thr Cys His
 1               5                  10                  15      
Asn Gly Thr Gly Gly Lys Ser
            20              


<210> 1676
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1676
Arg Ile Ile Lys Glu Ala Leu Pro Asp Gly Val Asn Ile Ser Lys Glu
 1               5                  10                  15      


<210> 1677
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1677
Arg Ile Ile Ile Met Cys Cys Ala Asn Ala Thr Gly Leu His Lys Leu
 1               5                  10                  15      


<210> 1678
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1678
Arg His Val Asn Leu Ser Ser Leu Val Ser Cys Leu Cys Val Asn Leu
 1               5                  10                  15      
Cys Ser Pro Tyr Leu Leu Leu Arg Arg Ala
            20                  25      


<210> 1679
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1679
Arg His Val Asn Leu Ser Ser Leu Val Pro Ser Leu Cys Val His Leu
 1               5                  10                  15      
Cys Ser Ser His Leu Leu Leu Arg Arg Ala Ala Val Ala Cys Leu Arg
            20                  25                  30          
Gln
    


<210> 1680
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1680
Arg His Arg Ala Gly Met Gln Asn Leu Thr Glu Phe Ile Gly Ser Glu
 1               5                  10                  15      
Pro Ser Lys Lys Arg Lys Arg Arg
            20                  


<210> 1681
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1681
Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His Val
 1               5                  10                  15      
Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg Pro
            20                  25                  30          
Val Met Lys
        35  


<210> 1682
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1682
Arg His Asn Leu Ser Leu His Ser Lys Phe Ile Lys Val His Asn Glu
 1               5                  10                  15      
Ala Thr Gly Lys Ser
            20      


<210> 1683
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1683
Arg His Asn Phe Thr Leu Ala Phe Ser Thr Ala Glu Lys Leu Ala Asp
 1               5                  10                  15      
Cys Ala Gln Leu Leu Asp Val
            20              


<210> 1684
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1684
Arg His Met Asp Met Leu Thr Ala Ala Asp Arg Leu Pro Thr Gln Ala
 1               5                  10                  15      
Pro Leu Ser Thr Ser Gln Ser Val Ser Gly Lys Asn Met Thr Ala Ser
            20                  25                  30          
Gln Gly Pro Cys
        35      


<210> 1685
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1685
Arg His Ile Lys Phe Tyr Asp Asn Asn Thr Gly Lys Leu
 1               5                  10              


<210> 1686
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1686
Arg His Ile Ala Asn Ser Ile Arg Thr His Gly Thr Gly Ile Met Asn
 1               5                  10                  15      
Thr Thr Lys Trp Ala Phe Thr Ala Trp Arg Gly Gly Pro
            20                  25                  


<210> 1687
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1687
Arg His Asp Gln Glu Asn Asp Thr Arg Trp
 1               5                  10  


<210> 1688
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1688
Arg His Cys Glu Ala Ala Ile Gly Asn Glu Thr Val Cys Thr Leu Trp
 1               5                  10                  15      
Gln Glu Gly Arg Cys
            20      


<210> 1689
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1689
Arg His Ala Gln Asn Val Thr Val Asp Glu Val Ile Gly Ala
 1               5                  10                  


<210> 1690
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1690
Arg Gly Tyr His Gly Asn Gly Thr His Ser Glu Ser Leu Glu His Arg
 1               5                  10                  15      
Gly
    


<210> 1691
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1691
Arg Gly Val Asn Gly Ser Pro Arg Ile Ser Val Thr Val Gly Asn Ile
 1               5                  10                  15      
Pro Lys Asn Ser Val Ser Ser Ser
            20                  


<210> 1692
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1692
Arg Gly Val Glu Gly Pro Gln Gly Ser Pro Arg Pro Pro Ala Pro Ile
 1               5                  10                  15      
Gln Gln Leu Asn Arg Ser Ser
            20              


<210> 1693
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1693
Arg Gly Thr Ser Gly Gln Pro Pro Glu Gly Cys Ala Ala Pro Thr Val
 1               5                  10                  15      
Ile Val Ser Asn His Asn Leu Thr Asp Thr Val Gln Asn Lys Gln
            20                  25                  30      


<210> 1694
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1694
Arg Gly Thr Glu Leu Asp Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile
 1               5                  10                  15      
Asn Asp Thr Asp Ala Asn Pro Arg Tyr
            20                  25  


<210> 1695
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1695
Arg Gly Ser Gln Ser Tyr Tyr Thr Val Ala His Ala Ile Ser Glu Trp
 1               5                  10                  15      
Val Glu Lys Gln Ser Ala Leu Leu Ile Asn Gly Thr Leu Lys His
            20                  25                  30      


<210> 1696
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1696
Arg Gly Ser Gly Ala Val Ala Glu Gly Asn Arg Thr Glu Ala Gly Ser
 1               5                  10                  15      
Gln Asp Tyr Ser Leu Leu Gln Ala Tyr Tyr Ser Gln Glu Ser Lys Val
            20                  25                  30          


<210> 1697
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1697
Arg Gly Arg Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn
 1               5                  10                  15      
Arg Thr
        


<210> 1698
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1698
Arg Gly Arg Pro Phe Pro Leu Ala Leu Leu Gly Trp Ala Pro Ser Asn
 1               5                  10                  15      
Ile Thr Phe Ala Leu Leu Phe Gly Arg Arg Phe
            20                  25          


<210> 1699
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1699
Arg Gly Arg Pro Ala Leu Pro Asn Pro Glu Gly Arg Ala Arg Glu Pro
 1               5                  10                  15      
Cys Pro Asn Arg Thr
            20      


<210> 1700
<211> 40
<212> PRT
<213> Homo sapiens

<400> 1700
Arg Gly Arg Gly Ala Ser Pro Arg Gly Gly Gly Pro Leu Ile Leu Leu
 1               5                  10                  15      
Asp Leu Asn Asp Glu Asn Ser Asn Gln Ser Phe His Ser Glu Gly Ser
            20                  25                  30          
Leu Pro Lys Gly Thr Glu Pro Ser
        35                  40  


<210> 1701
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1701
Arg Gly Pro Val Ser Ser Asp Val Glu Glu Asn Asp Ser Leu Asn Leu
 1               5                  10                  15      
Leu Gly Ile Leu Pro Asn Asn Ser Asp Ser Ala Lys Lys Asn
            20                  25                  30  


<210> 1702
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1702
Arg Gly Pro Ser His Pro Leu Asp Leu Gly Thr Ser Ser Pro Asn Thr
 1               5                  10                  15      
Ser Gln Ile His Trp Thr Pro Tyr Arg Ala
            20                  25      


<210> 1703
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1703
Arg Gly Pro Pro Ser Arg Gly Gly His Met Asp Asp Gly Gly Tyr Ser
 1               5                  10                  15      
Met Asn Phe Asn Met Ser Ser Ser Arg Gly Pro Leu Pro Val Lys Arg
            20                  25                  30          


<210> 1704
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1704
Arg Gly Pro His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser Glu
 1               5                  10                  15      
Ala Arg Gly Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala
            20                  25                  30      


<210> 1705
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1705
Arg Gly Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr
 1               5                  10                  15      
Ser Gly Gln Gln Gln Ser Asn Tyr Gly
            20                  25  


<210> 1706
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1706
Arg Gly Asn Thr Glu Leu Phe Gly Gly Gln Val Asp Gly Asp Asn Glu
 1               5                  10                  15      
Thr Leu Ser Val Val Ser Ala Ser Leu Ala
            20                  25      


<210> 1707
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1707
Arg Gly Asn Leu Asn Phe Thr Cys Asn Gly Asn Ser Val Ile Ser Pro
 1               5                  10                  15      
Val Gly Asn Arg Val
            20      


<210> 1708
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1708
Arg Gly Asn Glu Ala Thr Glu Gly Ser Gly Leu Leu Leu Asn Ser Thr
 1               5                  10                  15      
Gly Asp Leu Met Lys Lys
            20          


<210> 1709
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1709
Arg Gly Asn Cys Asp Ser Ser Gly Met Asn Leu Asn Asn Ile Ser Glu
 1               5                  10                  15      
Leu Ile Ile Ser Asn Arg Ser Ser
            20                  


<210> 1710
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1710
Arg Gly Met Tyr Leu Val Phe Asp Gly Ser Val Asp Leu His Tyr Asn
 1               5                  10                  15      
Cys Ser Ala Lys Cys Lys Ser
            20              


<210> 1711
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1711
Arg Gly Met Gly Pro Met Gly Thr Pro Ile Met Pro Ser Pro Ala Asp
 1               5                  10                  15      
Ser Thr Asn Ser Ser Asp Asn Ile Tyr Thr Met Thr Gly Gly Arg Ser
            20                  25                  30          


<210> 1712
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1712
Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val
 1               5                  10                  


<210> 1713
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1713
Arg Gly Leu Asp Ile Pro Leu Leu Asp Asn Val Ile Asn Tyr Ser Phe
 1               5                  10                  15      
Pro Ala Lys Gly Lys Leu
            20          


<210> 1714
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1714
Arg Gly Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn
 1               5                  10                  15      
Glu Arg Val
            


<210> 1715
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1715
Arg Gly Lys Arg Met Arg Pro Asn Ser Asn Thr Pro Val Asn Glu Thr
 1               5                  10                  15      
Ala Thr Ala Ser Asp Ser Lys Gly Thr Ser Asn
            20                  25          


<210> 1716
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1716
Arg Gly Lys Met Ala Asp Ser Ser Gly Arg Gly Ala Gly Lys Pro Ala
 1               5                  10                  15      
Thr Gly Pro Thr Asn Ser Ser Ser Ala Lys Lys
            20                  25          


<210> 1717
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1717
Arg Gly His Lys Ile Ser Asp Tyr Phe Glu Tyr Gln Gly Gly Asn Gly
 1               5                  10                  15      
Ser Ser Pro Val Arg Gly
            20          


<210> 1718
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1718
Arg Gly Gly Leu Gly Gly Gly Tyr Ser Gly Ala Ser Gly Met Gly Gly
 1               5                  10                  15      
Ile Thr Ala Val Met Val Asn Gln Ser Leu
            20                  25      


<210> 1719
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1719
Arg Gly Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly
 1               5                  10                  15      
Ile Thr Thr Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Asn Leu
            20                  25                  30          
Glu Val Asp Pro His
        35          


<210> 1720
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1720
Arg Gly Ala Thr Ala Ala Val Leu Ala Pro Asp Ser Ser Asn Ala Ser
 1               5                  10                  15      
Ser Glu Pro Ser Ser
            20      


<210> 1721
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1721
Arg Phe Val Glu Gly Thr Asn Ile Asn Arg Ser Leu Leu Ala Leu Gly
 1               5                  10                  15      
Asn Val Ile Asn Ala Leu Ala Asp Ser Lys Arg
            20                  25          


<210> 1722
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1722
Arg Phe Ser Gly Leu Leu Asn Cys Ser Pro Ala Ala Pro Pro Thr Ala
 1               5                  10                  15      
Pro Pro Ala Cys Glu Ala Lys Pro
            20                  


<210> 1723
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1723
Arg Phe Arg Ser Ser Gly Met Thr Leu Asp Asn Ile Ser Arg Ala
 1               5                  10                  15  


<210> 1724
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1724
Arg Phe Arg Gly Asn Leu Ser Gly Lys Arg Val Asp Phe Ser Gly Arg
 1               5                  10                  15      
Thr
    


<210> 1725
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1725
Arg Phe Gln Gly Asn Asp Thr Ser Pro Glu Ser Phe Leu Leu His Asn
 1               5                  10                  15      
Ala Leu Ala Arg Lys
            20      


<210> 1726
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1726
Arg Phe Asn Asn Ser Leu Leu Pro Thr Glu Pro Ser Gln Gln Leu Gln
 1               5                  10                  15      
Ala Tyr Val Ala Trp Val Asn Ala Gln Leu Lys Lys Arg Pro
            20                  25                  30  


<210> 1727
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1727
Arg Phe Leu Asn Asn Asp Ser Ser Gly Ala Glu Ala Asn Ser Glu Lys
 1               5                  10                  15      
Tyr
    


<210> 1728
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1728
Arg Phe Leu Leu Asn Asp Asn Leu Thr Leu Pro Pro Glu Met Tyr Val
 1               5                  10                  15      
Tyr Ser Thr Asn Ser Asp His Leu Pro Met Thr Ser Ser Phe Arg Lys
            20                  25                  30          


<210> 1729
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1729
Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr Phe
 1               5                  10                  15      
Ile Glu Asp Leu Lys Lys
            20          


<210> 1730
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1730
Arg Phe Leu Gly Thr Ser Gly Gln Asn Val Ser Asp Ile Phe Arg Tyr
 1               5                  10                  15      


<210> 1731
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1731
Arg Phe Ile Ile Val Ser Ala Phe Asp His Phe Ala Ser Val His Ser
 1               5                  10                  15      
Val Ser Ala Glu Gly Thr Val Val Ser Asn Leu Ser Ser
            20                  25                  


<210> 1732
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1732
Arg Phe Ile Gly Leu Thr Asn Ser Phe Gly Phe Gly Gly Thr Asn Ala
 1               5                  10                  15      
Thr
    


<210> 1733
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1733
Arg Phe His Phe Gln Gly Pro Cys Gly Arg Met Leu Pro Glu Pro Leu
 1               5                  10                  15      
Ala Gly His Glu Asn Glu Thr Val Ser
            20                  25  


<210> 1734
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1734
Arg Phe Gly Leu Leu Phe Asn Gln Glu Asn Thr Thr Tyr Ser Lys Thr
 1               5                  10                  15      


<210> 1735
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1735
Arg Phe Phe Val Glu Leu Val Gly His Tyr Ser Leu Asn Met Thr Val
 1               5                  10                  15      
Thr Glu
        


<210> 1736
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1736
Arg Phe Glu Lys Thr Asn Glu Met Leu Leu Asn Phe Asn Asn Leu Ser
 1               5                  10                  15      
Ser Ala Arg Leu Gln Gln Met Ser Glu Arg Phe
            20                  25          


<210> 1737
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1737
Arg Phe Cys Thr Gln Thr Leu Gly Val Asp Lys Gly Tyr Lys Asn Gln
 1               5                  10                  15      
Ser Phe Tyr Arg Lys His
            20          


<210> 1738
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1738
Arg Phe Ala Asn Gly Ser Ala Val Ile Gln Ser Gly Asp Thr Ala Val
 1               5                  10                  15      
Met Ala Thr Ala Val Ser Lys Thr
            20                  


<210> 1739
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1739
Arg Glu Tyr Asn Leu Asn Phe Ser Gly Ser Ser Thr Ile Gln Glu Val
 1               5                  10                  15      
Lys Arg
        


<210> 1740
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1740
Arg Glu Val Thr Asn Lys Asn Gly Thr Asn Val Phe Gln Glu Glu Ser
 1               5                  10                  15      
Arg Lys
        


<210> 1741
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1741
Arg Glu Val Asn Ser Thr Asp Trp Asp Ser Lys Met Gly Phe Trp Ala
 1               5                  10                  15      
Pro Leu Val Leu Ser His Ser Arg Arg
            20                  25  


<210> 1742
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1742
Arg Glu Thr Ala Leu Cys Ser Leu Asn Ser Ser His Gly Ile Val Ala
 1               5                  10                  15      
Phe Pro Ser Arg Ser Arg Ser
            20              


<210> 1743
<211> 38
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Any Amino Acid

<400> 1743
Arg Glu Ser Thr Gly Ala Gln Val Xaa Met Ala Gly Asp Met Leu Pro
 1               5                  10                  15      
Asn Ser Thr Glu Gln Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile
            20                  25                  30          
Ile Glu Cys Val Lys Gln
        35              


<210> 1744
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1744
Arg Glu Ser Ile Ala Ser Tyr Leu Ser Leu Thr Ser Glu Asp Asn Thr
 1               5                  10                  15      
Ser Phe Asp Arg Lys Lys Lys
            20              


<210> 1745
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1745
Arg Glu Ser Glu Glu Leu Glu Cys Asn Thr Gly Ser Asn Ile Thr Asn
 1               5                  10                  15      
Met His Gln Asp Lys Glu
            20          


<210> 1746
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1746
Arg Glu Gln Gln Asn Asp Thr Ser Ser Glu Leu Gln Asn Arg Glu
 1               5                  10                  15  


<210> 1747
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1747
Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr Glu Ser Gly Asp
 1               5                  10                  15      
Glu Val Pro Val
            20  


<210> 1748
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1748
Arg Glu Leu Ser Glu Met Arg Ala Pro Pro Ala Ala Thr Asn Ser Ser
 1               5                  10                  15      
Lys Lys
        


<210> 1749
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1749
Arg Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg
 1               5                  10                  15      
Pro
    


<210> 1750
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1750
Arg Glu Ile Val Ser Gln Thr Thr Ala Thr Gln Glu Lys Ser Gln Glu
 1               5                  10                  15      
Glu Leu Pro Thr Thr Asn Asn Ser Val Ser Lys Glu
            20                  25              


<210> 1751
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1751
Arg Glu Ile Thr Ala Ser Ser Ala Val Ser Ile Leu Ile Lys Pro Glu
 1               5                  10                  15      
Gln Glu Thr Asp Pro Leu Pro Val Val Ser Arg Asn Val Ser Ala Asp
            20                  25                  30          
Ala Lys Cys
        35  


<210> 1752
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1752
Arg Glu His Gly Ala Gln Ala Gly Glu Gly Ala Leu Lys Asp Ser Asn
 1               5                  10                  15      
Asn Asp Thr Asn
            20  


<210> 1753
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1753
Arg Glu His Glu Lys Leu Leu Met Glu Val Cys Arg Asn Cys Ser Ala
 1               5                  10                  15      
Val
    


<210> 1754
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1754
Arg Glu Gly Lys Glu Leu Leu Leu Tyr Phe Asp Ala Ser Leu Glu Ile
 1               5                  10                  15      
Thr Asn Val Thr Gln Lys Ile
            20              


<210> 1755
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1755
Arg Glu Gly Gly His Asp Val Pro Ser Asn Lys Asp Val Thr Ser Leu
 1               5                  10                  15      
Asp Trp Asn Thr Asn Gly Thr Leu Leu Ala Thr Gly Ser Tyr Asp Gly
            20                  25                  30          
Phe Ala Arg Ile
        35      


<210> 1756
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1756
Arg Glu Gly Glu Leu Cys Ser Leu Leu Lys Glu Asn Val Ser Glu Leu
 1               5                  10                  15      
Arg Ile Leu Ser Ser Gly Asn Asp His Gly Asn Trp Cys Ile Ile Ala
            20                  25                  30          
Glu Lys Lys Gly
        35      


<210> 1757
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1757
Arg Glu Glu Asn Asn Ile Ser Gly Leu Asn Gln Asp Ile Thr Asp Val
 1               5                  10                  15      
Cys Phe Ser Pro Glu Lys Asp
            20              


<210> 1758
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1758
Arg Glu Glu Asn Glu Gly Val Tyr Asn Gly Ser Trp Gly Gly Arg Gly
 1               5                  10                  15      


<210> 1759
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1759
Arg Glu Asp Gly Asp Gly Asp Glu Asp Gly Pro Ala Gln Gln Leu Ser
 1               5                  10                  15      
Gly Phe Asn Thr Asn Gln Ser Asn Asn Val Leu Gln Ala Pro Leu Pro
            20                  25                  30          
Pro Met Arg Leu
        35      


<210> 1760
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1760
Arg Glu Ala Tyr Ser Pro Leu Glu Leu Leu Asp Asn Leu Ser Gly Ala
 1               5                  10                  15      
Asp Val Arg Gln
            20  


<210> 1761
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1761
Arg Glu Ala Pro Gly Met Ala Leu Ala Met Leu Met Gly Ser Leu Asn
 1               5                  10                  15      
Val Thr Pro Leu
            20  


<210> 1762
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1762
Arg Glu Ala Phe Phe Gly Gly Asn Gly Lys Ile Asn Leu Thr Val Phe
 1               5                  10                  15      
Lys Leu
        


<210> 1763
<211> 41
<212> PRT
<213> Homo sapiens

<400> 1763
Arg Glu Ala Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Pro Asn
 1               5                  10                  15      
Ile Val Gly Val Tyr Gly Asn Thr Ala Val His Tyr Ala Val Asn Ser
            20                  25                  30          
Glu Asn Leu Ser Val Val Ala Lys Leu
        35                  40      


<210> 1764
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1764
Arg Asp Val Asn Ile Cys Asn Met Thr Ser His Leu Pro Ala Ala Ala
 1               5                  10                  15      
Ser Ala Ser Pro
            20  


<210> 1765
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1765
Arg Asp Val Met Trp Glu Asn Tyr Ser Asn Phe Ile Ser Leu Gly Pro
 1               5                  10                  15      
Ser Ile Ser Lys Pro Asp Val Ile Thr Leu Leu Asp Glu Glu Arg Lys
            20                  25                  30          


<210> 1766
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1766
Arg Asp Val Met Ser Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro
 1               5                  10                  15      
Ser Gln Glu Phe Val Asn Ile Thr Lys Tyr
            20                  25      


<210> 1767
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1767
Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Leu Gly Leu
 1               5                  10                  15      
Leu Gly Pro Lys Pro Asp Thr Phe Ser Gln Leu Glu Lys Arg Glu
            20                  25                  30      


<210> 1768
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1768
Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly Tyr
 1               5                  10                  15      
Leu Val Ala Lys Pro
            20      


<210> 1769
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1769
Arg Asp Ser Phe Gly Ala His Thr Tyr Glu Leu Leu Ala Lys Pro Gly
 1               5                  10                  15      
Gln Phe Ile His Thr Asn Trp Thr Gly His Gly Gly Ser Val Ser Ser
            20                  25                  30          
Ser Ser Tyr Asn Ala
        35          


<210> 1770
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1770
Arg Asp Pro Asn Ile Glu Ala Leu Asn Gly Asn Cys Ser Asp Thr Glu
 1               5                  10                  15      
Ile His Glu Lys Glu
            20      


<210> 1771
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1771
Arg Asp Asn Gly Pro Asp Gly Met Glu Pro Glu Cys Val Ile Glu Ser
 1               5                  10                  15      
Asn Trp Asn Glu Ile Val Asp Ser Phe Asp Asp Met Asn Leu Ser Glu
            20                  25                  30          
Ser Leu Leu Arg Asp
        35          


<210> 1772
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1772
Arg Asp Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys
 1               5                  10                  


<210> 1773
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1773
Arg Asp Met Ser Ile Ser Asn Thr Thr Met Asp Glu Phe Arg Gln
 1               5                  10                  15  


<210> 1774
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1774
Arg Asp Leu Asn Val Ser Val Thr His Leu Ile Ala Gly Glu Val Gly
 1               5                  10                  15      
Ser Lys Lys Tyr
            20  


<210> 1775
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1775
Arg Asp Leu Ala Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly
 1               5                  10                  15      
Ala Ala Gly Ser Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly
            20                  25                  30          
Ala Arg Gly
        35  


<210> 1776
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1776
Arg Asp Leu Ala Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly
 1               5                  10                  15      
Ala Ala Gly Gly Ala
            20      


<210> 1777
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1777
Arg Asp Lys Tyr Leu His Thr Asn Cys Leu Ala Ala Leu Ala Asn Met
 1               5                  10                  15      
Ser Ala Gln Phe Arg Ser
            20          


<210> 1778
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1778
Arg Asp Gly Asn Gly Thr Val Asp Phe Pro Glu Phe Leu Gly Met Met
 1               5                  10                  15      
Ala Arg Lys Met
            20  


<210> 1779
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1779
Arg Asp Gly Lys Asn Ala Thr Thr Asp Ala Leu Thr Ser Val Leu Thr
 1               5                  10                  15      
Lys Ile
        


<210> 1780
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1780
Arg Asp Gly Lys Glu Pro Gln Pro Ser Ala Glu Ala Ala Ala Ala Pro
 1               5                  10                  15      
Ser Leu Ala Asn Ile Ser Cys Phe Thr Gln Lys Leu
            20                  25              


<210> 1781
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1781
Arg Asp Gly Glu Gln Ser Pro Asn Val Ser Leu Met Gln Arg Met Ser
 1               5                  10                  15      
Asp Met Leu Ser Arg Trp
            20          


<210> 1782
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1782
Arg Asp Glu Asp Thr Leu Gln Asp Pro Ala Pro Leu Glu Thr Pro Met
 1               5                  10                  15      
Asn Ala Ser Ser Ser His Ser Cys
            20                  


<210> 1783
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1783
Arg Asp Asp Asn Met Asn Thr Ser Glu Asp Glu Asp Met Phe Pro Ile
 1               5                  10                  15      
Glu Met Ser Ser Asp Glu Ala Met Glu Leu Leu Glu Ser Ser Arg Thr
            20                  25                  30          


<210> 1784
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1784
Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala Arg
 1               5                  10                  15      
Leu Ser Leu Arg Lys
            20      


<210> 1785
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1785
Arg Cys Ser Val Gly Thr Tyr Asn Ser Ser Gly Ala Tyr Arg Phe
 1               5                  10                  15  


<210> 1786
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1786
Arg Cys Ser Ala Glu Glu Ala Thr Glu Gly Leu Met Asn Leu Ser Pro
 1               5                  10                  15      
Ser Ala Met Lys Asn
            20      


<210> 1787
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1787
Arg Cys Arg Glu Leu Arg Asn Phe Ser Ser Leu Arg Ala Ile Leu Ser
 1               5                  10                  15      
Ala Leu Gln Ser Asn Pro Ile Tyr Arg Leu
            20                  25      


<210> 1788
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1788
Arg Cys Asn Ser Ser Leu Ser Asn His Gln Arg Ile
 1               5                  10          


<210> 1789
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1789
Arg Cys Phe Leu Gln Leu Gln Pro Asp Asn Ser Thr Leu Thr Trp Val
 1               5                  10                  15      
Lys Pro Thr Thr Ala Ser Pro Ala Ser Ser Lys Ala Lys Leu
            20                  25                  30  


<210> 1790
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1790
Arg Cys Glu Gly Ser Gln Pro Trp Asn Leu Thr Pro Arg Gln
 1               5                  10                  


<210> 1791
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1791
Arg Cys Asp Arg Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser
 1               5                  10                  15      
Lys Ile
        


<210> 1792
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1792
Arg Cys Asp Lys Ala Phe Asn Gln Ser Ala Asn Leu Thr Lys His
 1               5                  10                  15  


<210> 1793
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1793
Arg Cys Cys Tyr Ser Leu Gly Asn Gly Ser Ser Gly Phe Arg Phe Leu
 1               5                  10                  15      
Lys Tyr Gly Gly Cys Gly Phe Pro Ser Leu Ser Tyr Gly Ser Arg Phe
            20                  25                  30          


<210> 1794
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1794
Arg Ala Val Asn Ala Leu Pro Gln Asn Met Thr Ser Gln Met Phe Ser
 1               5                  10                  15      


<210> 1795
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1795
Arg Ala Thr Pro Thr Pro Ser Pro Ala Asn Ala His Val Asn Gly Ser
 1               5                  10                  15      
Ala Asp Ala Pro Glu Asn Ala Leu His Leu Ala Glu Ala Gly Gly Leu
            20                  25                  30          
Cys Gly Glu Ser Arg Ala
        35              


<210> 1796
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1796
Arg Ala Ser Ser Pro Asn Ser Thr Val Ser Asn Thr Ser Thr Glu Gly
 1               5                  10                  15      
Phe Gly Gly Ile Met Ser Phe Ala Ser Ser Leu Tyr Arg Asn
            20                  25                  30  


<210> 1797
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1797
Arg Ala Arg Ala Gly His Thr Met Asn Thr Ser Pro Gly Thr Val Gly
 1               5                  10                  15      
Ser Asp Pro Val Ile Leu Ala Thr Ala Gly Tyr Asp His Thr Val Arg
            20                  25                  30          
Phe
    


<210> 1798
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1798
Arg Ala Gln Thr Glu Gly Ile Asn Ile Ser Glu Glu Ala Leu Asn His
 1               5                  10                  15      
Leu Gly Glu Ile Gly Thr Lys Thr Thr Leu Arg Tyr
            20                  25              


<210> 1799
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1799
Arg Ala Gln Pro Leu Ile Asn Leu Gln Met Val Asn Ala Ser Leu Tyr
 1               5                  10                  15      
Glu His Val Glu Arg Met
            20          


<210> 1800
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1800
Arg Ala Gln Ile Phe Ala Asn Thr Val Asp Asn Ser Ser Ile Ala Leu
 1               5                  10                  15      
Gln Thr Asp Asn Thr His Leu Ala Ala Asp Asp Leu Arg Val
            20                  25                  30  


<210> 1801
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1801
Arg Ala Pro Thr Phe Leu Met Asn Gln Thr Asp Thr His Ile Val Glu
 1               5                  10                  15      
Lys Met
        


<210> 1802
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1802
Arg Ala Asn His Thr Pro Glu Ser Cys Pro Glu Thr Lys Tyr Lys Val
 1               5                  10                  15      


<210> 1803
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1803
Arg Ala Asn Gly Thr Ala Gly Pro Thr Glu Asp His Thr Asp Asp Phe
 1               5                  10                  15      
Leu Gly Cys Leu Asn Ile Pro Val Arg Glu
            20                  25      


<210> 1804
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1804
Arg Ala Leu Ser Met Tyr Glu Glu Ala Phe Gln Asn Thr Ser Asp Ser
 1               5                  10                  15      
Asp Arg Tyr
            


<210> 1805
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1805
Arg Ala Ile Asn Met Gln Leu Asn Asn Gly Ser Ala Gly Gln Pro Ile
 1               5                  10                  15      
Arg Ser
        


<210> 1806
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1806
Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val Gly Gly
 1               5                  10                  15      
Phe Asn Gly Ser Leu Arg Val
            20              


<210> 1807
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1807
Arg Ala Phe Asp Met Leu Ser Glu Cys Gly Phe His Met Val Ala Cys
 1               5                  10                  15      
Asn Ser Ser Val Thr Ala Ser Phe Ile Asn Gln Tyr Thr Asp
            20                  25                  30  


<210> 1808
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1808
Arg Ala Glu Thr Gln Gly Ala Asn His Thr Pro Val Ile Ser Ala His
 1               5                  10                  15      
Gln Thr Arg Ser
            20  


<210> 1809
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1809
Arg Ala Cys Leu Gly Leu Ile Tyr Thr Val Tyr Val Asp Ser Leu Asn
 1               5                  10                  15      
Val Ser Leu Glu Ser Leu Ile Ala Asn Leu Cys Ala Cys Leu Val Pro
            20                  25                  30          
Ala Ala Gly
        35  


<210> 1810
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1810
Arg Ala Ala Gly Ser Ala Gln Gly Asn Asn Gln Ala Cys Asn Ser Thr
 1               5                  10                  15      
Ser Glu Val Lys Asp
            20      


<210> 1811
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1811
Gln Val Asn Gln Ser Ala Thr Ala Leu Lys His Val Phe Ala Ser Leu
 1               5                  10                  15      
Arg Leu
        


<210> 1812
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1812
Gln Thr Ile Ala Ala Ala Pro Ser Asn Gln Ser Leu Pro Pro Leu Pro
 1               5                  10                  15      
Ser Asn His Pro Ala Met Thr Lys Ser
            20                  25  


<210> 1813
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1813
Gln Arg Tyr Phe Val Ile Ser Asn Thr Thr Gly Tyr Asn Asp Arg Ala
 1               5                  10                  15      


<210> 1814
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1814
Gln Arg Asn Ala Glu Asn Thr Lys Ser Asn Val Thr His Lys
 1               5                  10                  


<210> 1815
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1815
Gln Gln Thr Thr Asn Thr Thr Ser Thr Gln Met Thr Asn Ile Gly Val
 1               5                  10                  15      
Tyr Val Ser Asn Met Thr Asp Lys Leu
            20                  25  


<210> 1816
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1816
Gln Asn Ser Glu Leu Gln Ala Lys Thr Asn Glu Thr Glu Lys Ala
 1               5                  10                  15  


<210> 1817
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1817
Gln Asn Ser Thr Gln Asp Ser Gly Pro Gln Glu Ser Glu Gly Ser Ala
 1               5                  10                  15      
Gly Asn Ser Leu Thr Val Ala Lys Asp
            20                  25  


<210> 1818
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1818
Gln Asn Ser Ser Gln Ser Ala Asp Gly Leu Arg Cys
 1               5                  10          


<210> 1819
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1819
Gln Lys Phe Asn Asp Ser Glu Gly Asp Asp Thr Glu Glu Thr Glu Asp
 1               5                  10                  15      
Tyr Arg Gln Phe Arg Lys Ser
            20              


<210> 1820
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1820
Gln Ile Val Ile Lys Met Phe Gln Asn Ile Ser Asn Ile Ile Lys Ser
 1               5                  10                  15      
Gly Lys Met
            


<210> 1821
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1821
Gln Gly Trp Pro Arg Pro Leu Thr Pro Pro Ala Ala Gly Gly Leu Gln
 1               5                  10                  15      
Asn His Thr Val Gly Ile Ile Val Lys Thr
            20                  25      


<210> 1822
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1822
Gln Glu Met Asn Val Ala Gln Phe Leu Met His Met Gly Phe Asp Met
 1               5                  10                  15      
Gln Thr Val Ala Gln Pro Gln Gly Leu Glu Pro Ser Glu Leu Leu Gly
            20                  25                  30          
Met Leu Ser Asn Gly Ser
        35              


<210> 1823
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1823
Gln Cys Ser Ser Leu Gly Ala Glu Ser Ile Leu Ser Gly Lys Glu Asn
 1               5                  10                  15      
Ser Ser Ala Leu Ser Pro Asn His Arg Ile
            20                  25      


<210> 1824
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1824
Pro Val Lys Leu Gly Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp
 1               5                  10                  15      
Ile Asn Asn Lys Lys Ser
            20          


<210> 1825
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1825
Pro Thr Ser Ser Met Asn Val Ser Met Met Thr Pro Ile Asn Asp Leu
 1               5                  10                  15      
His Thr Ala Asp Ser Leu Asn Leu Ala Lys Gly
            20                  25          


<210> 1826
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1826
Pro Thr Lys Ile Gly Ser Gly Arg Ser Ser Pro Val Thr Val Asn Gln
 1               5                  10                  15      
Thr Asp Lys Glu
            20  


<210> 1827
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1827
Pro Thr Phe Ser Leu Pro Leu Gln Leu Pro Pro Pro Val Asn Thr Ser
 1               5                  10                  15      
Lys Leu
        


<210> 1828
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1828
Pro Ser Arg Pro Ser Asn Ser Asn Ile Ser Lys Gly Glu Ser Arg Pro
 1               5                  10                  15      
Lys Trp
        


<210> 1829
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1829
Pro Ser Glu Thr Ser Pro Ile Ser Asn Ser Ser Ile Asn Glu Arg Met
 1               5                  10                  15      


<210> 1830
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1830
Pro Pro Asn Asn Val Ser Val Pro Leu Leu Met Pro Leu Val Thr Leu
 1               5                  10                  15      
Met Glu Arg Gln
            20  


<210> 1831
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1831
Pro Phe Arg Met Val Asn Glu Thr His Leu Asp Glu Ile Phe Ala Ser
 1               5                  10                  15      
Asn Thr Phe Ala Pro Ile Leu Leu Thr Lys Gly Leu Leu Ala Lys Lys
            20                  25                  30          


<210> 1832
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1832
Pro Phe Met Asn Ser Leu Gly Leu Val Thr Ser Asn Gly Leu Pro Glu
 1               5                  10                  15      
Val Glu Asn Leu Ser Lys Arg Tyr
            20                  


<210> 1833
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1833
Pro Phe Leu Ser Asp Ile His Asn Ile Ser Thr Leu Lys Ile
 1               5                  10                  


<210> 1834
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1834
Pro Glu Val Leu Ser Pro Leu Thr Leu Val Asn Thr Ser Gly Glu Ala
 1               5                  10                  15      
Gln Gly Thr Val Asp Arg Val
            20              


<210> 1835
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1835
Pro Ala Ser Ser Asp Phe Ser Asp Leu Asn Thr Gln Thr Asn Trp Thr
 1               5                  10                  15      
Lys Ser
        


<210> 1836
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1836
Asn Arg Asn Cys Ile Leu His Leu Leu Ser Lys Asn Trp Ser Arg Arg
 1               5                  10                  15      


<210> 1837
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1837
Asn Gln Gly Asn Phe Ser Val Val Gly Thr Val Leu Ala Ala Thr Gln
 1               5                  10                  15      
Ala Glu Lys Ala Val Ala Asn Phe Asp Arg Thr
            20                  25          


<210> 1838
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1838
Asn Asn Glu Ser Ser Ser Glu Gly Phe Ile Cys Pro Gln Cys Met Lys
 1               5                  10                  15      
Ser
    


<210> 1839
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1839
Asn Met Ile Asn Ala Thr Ile Lys Gln Asp Asp Pro Phe Asn Ile Asp
 1               5                  10                  15      
Leu Gly Gln Gln Ser Gln Arg Ser
            20                  


<210> 1840
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1840
Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr Asp Ala Val Pro
 1               5                  10                  15      
Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile Thr Lys Met
            20                  25                  30      


<210> 1841
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1841
Asn Ile Ser Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys Ser
 1               5                  10                  15  


<210> 1842
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1842
Asn Ile Ala Pro Asn Ile Ser Arg Ala Glu Ile Ile Ser Leu Cys Lys
 1               5                  10                  15      
Arg
    


<210> 1843
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1843
Asn Gly Pro Asp Thr Asn His Gln Asn Pro Gln Asn Lys Thr Ser Pro
 1               5                  10                  15      
Phe Ser Val Ser Pro Thr Gly Pro Ser Thr Lys Ile
            20                  25              


<210> 1844
<211> 38
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 22
<223> Xaa = Any Amino Acid

<400> 1844
Asn Gly Asn Ser Val Ala Leu Ser Leu Ser Asp Ile Leu Trp Asn Gly
 1               5                  10                  15      
Pro Val Gly Thr Val Xaa Ile Gly Met Thr Asp Gly Glu Cys Val Val
            20                  25                  30          
Asn Pro Thr Arg Lys Glu
        35              


<210> 1845
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1845
Asn Phe Ser Val Thr Asn Leu Ser Gln Thr Asp Glu Ile Pro Val Leu
 1               5                  10                  15      
Thr Leu Lys Asp
            20  


<210> 1846
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1846
Asn Phe Gly His Asn Asp Ser Thr Ser Gln Met Ser Leu Asn Ser Ala
 1               5                  10                  15      
Ala Val Thr Lys Thr
            20      


<210> 1847
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1847
Asn Glu Leu Cys Arg Leu Gly Ala Leu Asp Ile Leu Glu Glu Val Asn
 1               5                  10                  15      
Val Ser Gly Thr Arg Lys Asn
            20              


<210> 1848
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1848
Asn Asp Asn Phe Gly Ile Gly Gly Asn Phe Ser Gly Leu Gly Gly Phe
 1               5                  10                  15      
Gly Gly Ser Arg Gly
            20      


<210> 1849
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1849
Met Tyr Val Asp Asn Asn Arg Ser Trp Phe Met His Cys Asn Ser His
 1               5                  10                  15      
Thr Asn Arg Thr
            20  


<210> 1850
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1850
Met Val Tyr Asn Cys Thr Thr Gly Ser Thr Asn Pro Phe His Trp Gly
 1               5                  10                  15      
Glu Val Gly Met Ile Leu Pro Val Phe Leu Asn Val Arg Ile
            20                  25                  30  


<210> 1851
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1851
Met Val Val Leu Glu Trp Leu Ala Asn Pro Ser Asn Asp Met Tyr Ala
 1               5                  10                  15      
Asp Thr Val Thr Thr Val Ile Leu Glu Val Gln Ser Asn Pro Lys Ile
            20                  25                  30          
Arg Lys
        


<210> 1852
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1852
Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln
 1               5                  10                  15      
Gln Asn Asn Ala Thr Lys Thr
            20              


<210> 1853
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1853
Met Val Asn Gln Ser Leu Leu Asn Pro Leu Asn Leu Glu Val Asp Pro
 1               5                  10                  15      
Asn Ile Gln Ala Val Cys Thr Gln Glu Lys Lys
            20                  25          


<210> 1854
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1854
Met Val Asp Ala Ala Ser Tyr Ala Ala Asn Leu Thr Asp Ser Ala Glu
 1               5                  10                  15      
Ala Pro Lys Gly Ser Pro Gly Ser Trp Trp Lys Lys Glu
            20                  25                  


<210> 1855
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1855
Met Val Ala Gly Leu Leu Asn Ser Gly Asn Ser Asn Lys Thr Ile His
 1               5                  10                  15      
Thr Ser Ser Ser Ile Lys Leu
            20              


<210> 1856
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1856
Met Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile Gln
 1               5                  10                  15      
Asp Phe Leu Arg Lys Gly
            20          


<210> 1857
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1857
Met Thr Trp Ser Phe Gly Trp Asn Ser Ser Leu Pro Val Tyr Tyr Ile
 1               5                  10                  15      
Arg Glu
        


<210> 1858
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1858
Met Thr Arg Asp Gln Asn Gly Thr Trp Glu Met Glu Ser Asn Glu Asn
 1               5                  10                  15      
Phe Glu Gly Tyr Met Lys Ala
            20              


<210> 1859
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1859
Met Thr Asn Thr Ser Tyr Ser Glu Pro Ala Gln Asn Ser Lys Leu Ser
 1               5                  10                  15      
Leu Lys Gln
            


<210> 1860
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1860
Met Thr Asn Gly Thr Leu Glu Pro Ala Ala Glu Trp Ser Val Leu Leu
 1               5                  10                  15      
Gly Val His Ser Gln Asp Gly Pro Leu Asp Gly Ala His Thr Arg Ala
            20                  25                  30          


<210> 1861
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1861
Met Thr Asn Ala Ser Asn Ser Gln Gln Ser Ile Ser Met Gln Gln Phe
 1               5                  10                  15      
Ser Gln Thr Ser Asn Pro Ser Ala His Phe His Lys Cys
            20                  25                  


<210> 1862
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1862
Met Ser Val Thr Phe Ile Ser Asn Asn Thr Ala Ile Gln Glu Leu Phe
 1               5                  10                  15      
Arg Phe Arg Cys
            20  


<210> 1863
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1863
Met Ser Thr Ile Ser Cys His Gln Asp Val Ile Leu Ser Met Ser Phe
 1               5                  10                  15      
Asn Thr Asn Gly Ser Leu Leu Ala Thr Thr Cys Lys Asp Arg Lys
            20                  25                  30      


<210> 1864
<211> 38
<212> PRT
<213> Homo sapiens

<400> 1864
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser
 1               5                  10                  15      
Ser Ser Thr Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala
            20                  25                  30          
Gly Ala Ala Asp Lys Ser
        35              


<210> 1865
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1865
Met Ser Ser His Phe Tyr Ile Asn Asp Val Asn Phe Thr Arg Lys Met
 1               5                  10                  15      
Leu Leu Met Phe Phe Glu Val Ser Ala His Glu Ser
            20                  25              


<210> 1866
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1866
Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro Gly Thr Ala Ile Asn
 1               5                  10                  15      
Gly Thr Leu Pro Leu Ser His
            20              


<210> 1867
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1867
Met Ser Gln Gly Ala Val Ala Asn Ala Asn Ser Thr Pro Pro Pro Tyr
 1               5                  10                  15      
Glu Arg Thr Arg Leu
            20      


<210> 1868
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1868
Met Ser Asn Val Glu Gln Ala Leu Phe Ala Arg Leu Leu Leu Gln Asp
 1               5                  10                  15      
Pro Gly Asn His Leu Ile Asn Met Thr Ser Ser Thr Thr Leu Asn Leu
            20                  25                  30          
Ser Ala Asp Arg Asp
        35          


<210> 1869
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1869
Met Ser Asn Tyr Ser Ser Ser Ser Leu Leu Ser Gly Ala Gly Lys Asp
 1               5                  10                  15      


<210> 1870
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1870
Met Ser Leu Asp Phe Asn Ala Thr Gly Arg Ile Thr Ala Ala Gln Leu
 1               5                  10                  15      
Gln Thr Met Leu Leu Glu Lys Ser Arg Val
            20                  25      


<210> 1871
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1871
Met Ser His Phe Pro Asp Arg Gly Ser Glu Asn Gly Thr Pro Met Asp
 1               5                  10                  15      
Val Lys Ala Gly Val Arg Val
            20              


<210> 1872
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1872
Met Ser Gly Thr Thr Thr Ser Thr Asn Thr Phe Pro Gly Gly Pro Ile
 1               5                  10                  15      
Ala Thr Leu Phe Asn Met Ser Met Ser Ile Lys Asp
            20                  25              


<210> 1873
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1873
Met Ser Gly Arg Glu Glu Thr Glu Lys Val Asn Thr Ser Pro Ser Val
 1               5                  10                  15      
Asn Thr Lys Thr Thr Thr Glu Ser Lys Ala
            20                  25      


<210> 1874
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1874
Met Ser Asp His Leu Cys Ser Met Asn Glu Thr Leu Ser Lys Gln Arg
 1               5                  10                  15      
Glu
    


<210> 1875
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1875
Met Ser Ala Cys Asn Ile Ser Ile Gln Gly Pro Ser Ile Tyr Asn Lys
 1               5                  10                  15      
Glu
    


<210> 1876
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1876
Met Arg Val Asn Asn Ser Thr Met Leu Gly Ala Ser Gly Asp Tyr Ala
 1               5                  10                  15      
Asp Phe Gln Tyr Leu Lys Gln
            20              


<210> 1877
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1877
Met Arg Ser Phe Leu Gln Gln Asp Val Asn Lys Thr Lys Ser Arg Leu
 1               5                  10                  15      


<210> 1878
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1878
Met Arg Pro Arg Gly Gln Pro Ala Asp Ile Arg Gln Gln Pro Gly Met
 1               5                  10                  15      
Met Pro His Gly Gln Leu Thr Thr Ile Asn Gln Ser Gln Leu Ser Ala
            20                  25                  30          
Gln Leu Gly Leu
        35      


<210> 1879
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1879
Met Arg Asn Leu Gln Phe Thr Thr Ile Ser Leu Asn Phe Ser Thr Thr
 1               5                  10                  15      
Lys Thr
        


<210> 1880
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1880
Met Arg Gly Ile Glu Thr Val Leu Leu Ile Lys Asn Asn Ser Val Ala
 1               5                  10                  15      
Arg Ala Val Met Gln Ser Gln Lys Pro
            20                  25  


<210> 1881
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1881
Met Gln Thr Thr Asp Leu Glu Gln Thr Ser Pro Pro Val Asn Gln Ala
 1               5                  10                  15      
Pro Asn Gln Thr Lys Leu Glu Val Lys Ala
            20                  25      


<210> 1882
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1882
Met Gln Arg Leu Asn Ile Gly Tyr Val Ile Asn Val Thr Thr His Leu
 1               5                  10                  15      
Pro Leu Tyr His Tyr Glu Lys Gly
            20                  


<210> 1883
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1883
Met Gln Gln His Asn Met Ser Trp Ile Glu Val Gln Phe Leu Lys Lys
 1               5                  10                  15      


<210> 1884
<211> 24
<212> PRT
<213> Homo sapiens

<400> 1884
Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp Thr Leu Thr Asn
 1               5                  10                  15      
Ser Ser Ser Phe Glu Gly Tyr Ile
            20                  


<210> 1885
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1885
Met Gln Asn Asn Trp Cys Phe Pro Ala Cys Ser Phe Asn Gly Thr Ser
 1               5                  10                  15      
Ala Gln Glu Trp Phe Met Ala Gln Asp Cys Pro Tyr Arg Lys Arg
            20                  25                  30      


<210> 1886
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1886
Met Gln Lys Ser Thr Asn Ser Asp Thr Ser Val Glu Thr Leu Asn Ser
 1               5                  10                  15      
Thr Arg Gln
            


<210> 1887
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1887
Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro Pro
 1               5                  10                  15      
Asn Arg Glu
            


<210> 1888
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1888
Met Gln Glu Leu Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln
 1               5                  10                  


<210> 1889
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1889
Met Pro Val Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn Ala
 1               5                  10                  15      
Ile Asn Arg Tyr Thr Asn Thr Ser Lys Thr
            20                  25      


<210> 1890
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1890
Met Pro Ser Asn Ser Ser Ala Ser Ile Ser Lys Leu Arg Glu
 1               5                  10                  


<210> 1891
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1891
Met Pro Pro Val Ser Leu Asn His Asn Leu Thr Thr Pro Phe Thr Ser
 1               5                  10                  15      
Gln Ala Gly Glu Asn Ser Leu Phe Met
            20                  25  


<210> 1892
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1892
Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu Val Ser Ser
 1               5                  10                  15      
Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly Gly Tyr Asn
            20                  25                  30          
Leu Ser Ala Arg Cys
        35          


<210> 1893
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1893
Met Pro Asp Thr Pro Asp Ile Leu Leu Ala Lys Ser Asn Ser Ala Asn
 1               5                  10                  15      
Ile Ser Gln Lys Leu Tyr Thr Lys Gly
            20                  25  


<210> 1894
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1894
Met Asn Trp Val Val Gly Ser Ala Asp Leu Glu Ile Ile Asn Ala Thr
 1               5                  10                  15      
Thr Gly Arg Arg
            20  


<210> 1895
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1895
Met Asn Ser Glu Phe Asn Leu Ser Leu Leu Ala Pro Cys Leu Ser Leu
 1               5                  10                  15      
Gly Met Ser Glu Ile Ser Gly Gly Gln Lys Ser
            20                  25          


<210> 1896
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1896
Met Asn Gln Asn Ala Gln Leu Leu Ile Gln Gln Ser Ser Leu Glu Asn
 1               5                  10                  15      
Glu Asn Glu Ser Val Ile Lys Glu Arg Glu
            20                  25      


<210> 1897
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1897
Met Asn Lys Trp Ala Gly Leu Leu Gly Pro Ile Ser Asn His Ser Phe
 1               5                  10                  15      
Gly Gly Ser Phe Arg Thr Ala Ser Asn Lys Glu
            20                  25          


<210> 1898
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1898
Met Asn Glu Ile Leu Thr Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe
 1               5                  10                  15      
Asp Pro Asn Thr Glu Glu Asn Leu Thr Tyr Leu Gln Leu Met Glu Arg
            20                  25                  30          
Cys
    


<210> 1899
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1899
Met Asn Asp Gln Asp Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp
 1               5                  10                  15      
Arg Leu
        


<210> 1900
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1900
Met Asn Thr Ser Thr Val Asn Ser Ala Arg Glu
 1               5                  10      


<210> 1901
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1901
Met Asn Ser Thr Asp Ile Gln Trp Ser Ala Ile Leu Ser Trp Gly Tyr
 1               5                  10                  15      
Ala Asp Asn Ile Leu Arg Leu Lys Ser
            20                  25  


<210> 1902
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1902
Met Asn Arg Ser Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys
 1               5                  10                  15      
Ile
    


<210> 1903
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1903
Met Asn Asn Ser Gln Gly Arg Val Thr Phe Glu Asp Val Thr Val Asn
 1               5                  10                  15      
Phe Thr Gln Gly Glu Trp Gln Arg Leu
            20                  25  


<210> 1904
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1904
Met Asn Asn Ser Leu Asp Tyr Leu Ala Tyr Pro Val Ile Val Ser Asn
 1               5                  10                  15      
His Arg Gln Ser Thr Thr Phe Arg Lys
            20                  25  


<210> 1905
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1905
Met Asn Asn Ser Cys Leu Thr Asn Ala Val His Leu Asn Asn Val Ser
 1               5                  10                  15      
Val Val Ser Pro Val Asn Val His Ile Asn Thr Arg Thr
            20                  25                  


<210> 1906
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1906
Met Asn Ile Ser Leu Ala Phe Phe Leu Tyr Asp Leu Leu Ser Leu Met
 1               5                  10                  15      
Asp Arg Gly
            


<210> 1907
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1907
Met Asn Gly Thr Ser Ser Gln Pro Lys Lys Glu Glu Tyr Gly Ser
 1               5                  10                  15  


<210> 1908
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1908
Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys Gly Ile Leu His
 1               5                  10                  15      
Glu Ala Ala Met Gln Tyr Pro Lys Gln
            20                  25  


<210> 1909
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1909
Met Met Gln Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser
 1               5                  10                  15      
Leu Asn Ser Pro Ser Pro Asn Tyr Gln Lys Tyr
            20                  25          


<210> 1910
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1910
Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly
 1               5                  10                  15      
Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu
            20                  25          


<210> 1911
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1911
Met Leu Thr Thr His Pro Ser Leu Tyr Arg Val Asp Asn Leu Ser Asp
 1               5                  10                  15      
Glu Gly Ala Leu Asn Ile Ser Asp Arg Thr
            20                  25      


<210> 1912
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1912
Met Leu Ser Ser Ser Ser Glu Met Asn Glu Glu Phe Leu Lys Glu Asn
 1               5                  10                  15      
Asn Ser Val Glu Tyr Lys Lys Ser Lys Ala
            20                  25      


<210> 1913
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1913
Met Leu Arg Asn Val Thr Gln Met Ser Lys
 1               5                  10  


<210> 1914
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1914
Met Leu Gln Tyr Gly Gly Arg Asn Arg Thr Val Ala Thr Pro Ser His
 1               5                  10                  15      
Gly Val Trp Asp Met Arg Gly Lys Gln
            20                  25  


<210> 1915
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1915
Met Leu Gln Asp Asp Asn Thr Ser Ala Gly Leu His Phe Met Ala Ser
 1               5                  10                  15      
Val Lys Lys
            


<210> 1916
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1916
Met Leu Pro Asn Pro Ser His Leu Glu Ala Val Asn Pro Val Ala Val
 1               5                  10                  15      
Gly Lys Thr Arg Gly Arg Gln
            20              


<210> 1917
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1917
Met Leu Asn Leu Ser Ser Tyr Pro Ile Trp Val Ser Leu Phe Arg Gly
 1               5                  10                  15      
Ser Pro Arg Arg
            20  


<210> 1918
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1918
Met Leu Leu Asn Gly Thr Pro Phe Ala Phe Val Ile Asp Leu Ala Ala
 1               5                  10                  15      
Leu Ala Ser Arg Arg Glu
            20          


<210> 1919
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1919
Met Leu Ile Ser Val Glu Ser Pro Asn Leu Thr Thr Pro Ile Thr Ser
 1               5                  10                  15      
Asn Pro Thr Asp Thr Arg Lys
            20              


<210> 1920
<211> 32
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Any Amino Acid

<400> 1920
Met Leu Gly Ser Glu Met Xaa Gly Gln Asn Val Ser Asn Pro Ala Pro
 1               5                  10                  15      
Ser Pro Ser Leu Ser Gly Val Ser Trp Pro Asp Asn Val Pro Lys Ile
            20                  25                  30          


<210> 1921
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1921
Met Leu Gly Gly Tyr Gly His Ile Ser Ser Ser Ile Asp Ile Asn Ser
 1               5                  10                  15      
Ser Arg Lys
            


<210> 1922
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1922
Met Leu Glu Asn Pro Leu Asn Ser Thr Gln Trp Met Asn Asp Pro Glu
 1               5                  10                  15      
Thr Gly Pro Val Met Leu Gln Ile Ser Arg Ile
            20                  25          


<210> 1923
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1923
Met Leu Ala Ser Asn His Met Asn Gly Ser Asn Gly Glu Ser Pro Leu
 1               5                  10                  15      
Ala
    


<210> 1924
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1924
Met Leu Ala Gln Glu Gly Met Leu Ala Asn Leu Val Glu Gln Asn Ile
 1               5                  10                  15      
Ser Val Arg Arg Arg
            20      


<210> 1925
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1925
Met Lys Val Lys Thr Asn Ala Ser Gln Val Pro Ala Glu Pro Lys Glu
 1               5                  10                  15      


<210> 1926
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1926
Met Lys Thr Gln Glu Pro Ala Gly Ser Leu Glu Glu Asn Asn Ser Asp
 1               5                  10                  15      
Lys Asn
        


<210> 1927
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1927
Met Lys Pro Val Asn Gln Thr Ala Ala Ser Asn Lys Gly Leu Arg Gly
 1               5                  10                  15      


<210> 1928
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1928
Met Lys Asn Ser Cys Asn Val Leu His Pro Gln Ser Pro Asn Asn Ser
 1               5                  10                  15      
Asn Arg Gln
            


<210> 1929
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1929
Met Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys
 1               5                  10                  15      
Val Lys Arg
            


<210> 1930
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1930
Met Lys Met Tyr Ser Asp Ala Phe Leu Asn Asp Ser Tyr Leu Lys Tyr
 1               5                  10                  15      


<210> 1931
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1931
Met Lys Phe Arg Asn Ser Ser Val Ala Met Gly Ala Ser Leu Ser Cys
 1               5                  10                  15      
Ser Glu Tyr Ser Leu Lys Val
            20              


<210> 1932
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1932
Met Lys Phe Arg Gly Asn Gly Ala Leu Ser Asn Ile Ser Asp Leu Pro
 1               5                  10                  15      
Phe Leu Ala Glu Asn Ser Ala Phe Pro Lys Met
            20                  25          


<210> 1933
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1933
Met Lys Glu Asn Pro Ala Lys Glu Gln Leu Trp Ala Leu Glu Gln Asp
 1               5                  10                  15      
Asn Cys Ser Leu Ala Asn Leu Val Cys Lys Val
            20                  25          


<210> 1934
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1934
Met Lys Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly
 1               5                  10                  15      
Val Pro Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile
            20                  25                  30  


<210> 1935
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1935
Met Ile Thr Val Val Gln Thr Tyr Ser Thr Leu Ser Asn Ser Thr Ile
 1               5                  10                  15      
Glu Gly Ile Asp Ile Met Ala Ile Lys Phe Arg Asn
            20                  25              


<210> 1936
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1936
Met Ile Asn Asn Thr Lys Ala Phe Ile His His Glu Leu Leu Ala Tyr
 1               5                  10                  15      
Leu Tyr Ser Ser Ala Asp Gln Ser Ser Leu Met Glu Glu Ser Ala Asp
            20                  25                  30          
Gln Ala Gln Arg Arg
        35          


<210> 1937
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1937
Met Ile Leu Leu Asn Asn Ser Gln Lys Leu Leu Val Leu Tyr Lys Pro
 1               5                  10                  15      
Leu Ala Trp Ser Ile Pro Glu Ser Leu Lys Val
            20                  25          


<210> 1938
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1938
Met His Ser Ser Asn Phe Ser Ser Ser Asn Gly Ser Thr Glu Asp Leu
 1               5                  10                  15      
Phe Arg Asp
            


<210> 1939
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1939
Met His Leu Thr Thr Leu Cys Asn Thr Ser Leu Asp Asn Pro Thr Gln
 1               5                  10                  15      
Arg Asn
        


<210> 1940
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1940
Met Gly Tyr Leu Cys Thr His Gln Leu Leu Phe Leu Gln Leu Asn Gln
 1               5                  10                  15      
Ser Ser Phe Asn Ser Lys Asn
            20              


<210> 1941
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1941
Met Gly Val Tyr Gly Gln Glu Ser Gly Gly Phe Ser Gly Pro Gly Glu
 1               5                  10                  15      
Asn Arg Ser Met Ser Gly Pro Asp Asn Arg Gly Arg Gly
            20                  25                  


<210> 1942
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1942
Met Gly Thr Pro Ser Gln Thr Ser Gln Asp Thr Ser Leu Glu Thr Gly
 1               5                  10                  15      
Gln Gly Tyr Glu Asp Glu Gln Asp Gly Trp Asn Ser Ser Ser Lys Thr
            20                  25                  30          
Thr Arg Val
        35  


<210> 1943
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1943
Met Phe Arg Met Leu Asn Ser Ser Phe Glu Asp Asp Pro Phe Phe Ser
 1               5                  10                  15      
Glu Ser Ile Leu Ala His Arg Glu Asn Met Arg Gln
            20                  25              


<210> 1944
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1944
Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His Asp Val Tyr
 1               5                  10                  15      
His Met Ala Val Glu Met Gln Arg Asp
            20                  25  


<210> 1945
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1945
Met Phe Pro Val Leu Phe Pro Phe Asn Pro Ser Ser Leu Thr Met Asp
 1               5                  10                  15      
Ser Ile His Ile Pro Ala Cys Leu Asn Leu Glu Phe Leu Asn Glu Val
            20                  25                  30          


<210> 1946
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1946
Met Phe Asn Gln Asp Ile Glu Lys Leu Val Glu Gly Glu Glu Val Val
 1               5                  10                  15      
Arg Glu Asn Glu Thr Arg Leu
            20              


<210> 1947
<211> 11
<212> PRT
<213> Homo sapiens

<400> 1947
Met Phe Asn Ile Ser Pro Gly Ala Val Gln Phe
 1               5                  10      


<210> 1948
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1948
Met Phe Lys Met Ala Lys Asn Trp Ser Ala Ala Gly Asn Ala Phe Cys
 1               5                  10                  15      
Gln Ala Ala Lys Leu His Met Gln Leu Gln Ser Lys His
            20                  25                  


<210> 1949
<211> 35
<212> PRT
<213> Homo sapiens

<400> 1949
Met Phe Cys Asn Gln Gln Ser Val Cys Asp Pro Pro Ser Gln Asn Asn
 1               5                  10                  15      
Ala Ala Asn Ile Ser Met Val Gln Ala Ala Ser Ala Gly Pro Pro Ser
            20                  25                  30          
Leu Arg Lys
        35  


<210> 1950
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1950
Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr Phe Met Lys Ala
 1               5                  10                  15      


<210> 1951
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1951
Met Glu Thr Ser Ile Ser Thr Gly Gly Asn Ser Ala Cys Ser Pro Asp
 1               5                  10                  15      
Asn Met Ser Ser Ala Ser Gly Leu Asp Met Gly Lys Ile
            20                  25                  


<210> 1952
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1952
Met Glu Ser Leu Ala Leu Ser Asn Ala Thr Gly Leu Ser Ala Asp Gly
 1               5                  10                  15      
Gly Ala Lys Arg Gln
            20      


<210> 1953
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1953
Met Glu Arg Glu Ser Leu Lys Ser Pro Phe Thr Gly Asp Thr Ser Met
 1               5                  10                  15      
Asn Asn Leu Glu Thr Val His His Asn Asn Ser Lys Ala Asp Lys Leu
            20                  25                  30          
Lys Glu
        


<210> 1954
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1954
Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly Asp Ser Ala Gly
 1               5                  10                  15      
Arg Ser
        


<210> 1955
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1955
Met Glu Asn Ile Leu Ser Gly Asn Pro Leu Leu Asn Leu Thr Gly Pro
 1               5                  10                  15      
Ser Gln Pro Gln Ala Asn Phe Lys Val
            20                  25  


<210> 1956
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1956
Met Glu Gly Phe Asn Ser Gly Leu Asn Ser Gly Gly Ser Thr Asn Ser
 1               5                  10                  15      
Ser Pro Lys Val
            20  


<210> 1957
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1957
Met Asp Ser Ser Leu Val Ser Gln Gln Pro Pro Asp Asn Gln Glu Lys
 1               5                  10                  15      
Glu Arg Leu Asn Thr Ser Ile Pro Gln Lys Arg Lys
            20                  25              


<210> 1958
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1958
Met Asp Gln Met Ala Val Leu Leu Val Ser Asn Ile Asn Glu Ser Lys
 1               5                  10                  15      
Gly
    


<210> 1959
<211> 15
<212> PRT
<213> Homo sapiens

<400> 1959
Met Asp Leu Gln Asn Met Thr Met Gly Thr Leu Val Ser Lys Ala
 1               5                  10                  15  


<210> 1960
<211> 27
<212> PRT
<213> Homo sapiens

<400> 1960
Met Asp Gly Met Asn Ser Ser Gly Val Tyr Ala Ser Pro Thr Cys Ser
 1               5                  10                  15      
Asn Met Ala His His Ala Leu Ser Phe Arg Gly
            20                  25          


<210> 1961
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1961
Met Cys Tyr Ala Cys Asn Lys Ser Ile Thr Ala Lys Glu Ala Leu Ile
 1               5                  10                  15      
Cys Pro Thr Cys Asn Val Thr Ile His Asn Arg Cys
            20                  25              


<210> 1962
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1962
Met Cys Gln Glu Leu Glu Thr Gly Ile Val Asp Leu Leu Ile Pro Ser
 1               5                  10                  15      
Pro Asn Ala Thr Ala Glu Val Gly Tyr Asn Arg Asp
            20                  25              


<210> 1963
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1963
Met Ala Val Arg Gly Leu Ile Arg Pro Met Asn Lys Ser Pro Met Leu
 1               5                  10                  15      
Ile Thr Gly Ile Arg Cys
            20          


<210> 1964
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1964
Met Ala Thr Tyr Ser Ala Thr Cys Ala Asn Asn Ser Pro Ala Gln Gly
 1               5                  10                  15      
Ile Asn Met Ala Asn Ser Ile Ala Asn Leu Arg Leu Lys Ala
            20                  25                  30  


<210> 1965
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1965
Met Ala Thr Arg Thr Leu Asn Leu Ser Phe Phe Pro Arg Ser
 1               5                  10                  


<210> 1966
<211> 23
<212> PRT
<213> Homo sapiens

<400> 1966
Met Ala Asn Val Thr Trp Pro Gln Gly Pro Phe Thr Thr Trp Ser Thr
 1               5                  10                  15      
Thr Gly Asp Ala Pro Val Ile
            20              


<210> 1967
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1967
Met Ala Asn Arg Thr Asp Asn Thr Asn Arg Thr Gly Asp Ala Thr Val
 1               5                  10                  15      
Ile Lys Gln Glu Met Leu Thr Gly Gln Glu Met Pro Arg Glu
            20                  25                  30  


<210> 1968
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1968
Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn Gly Thr Ser
 1               5                  10                  15      
Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu
            20                  25      


<210> 1969
<211> 40
<212> PRT
<213> Homo sapiens

<400> 1969
Met Ala Ala Ala Asn Pro Trp Asp Pro Ala Ser Ala Pro Asn Gly Ala
 1               5                  10                  15      
Gly Leu Val Leu Gly His Phe Ile Ala Ser Gly Met Val Asn Gln Glu
            20                  25                  30          
Met Leu Asn Met Ser Lys Lys Thr
        35                  40  


<210> 1970
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1970
Leu Ser Met Leu Asn Gly Thr Lys Val Leu Ser Asp
 1               5                  10          


<210> 1971
<211> 20
<212> PRT
<213> Homo sapiens

<400> 1971
Leu Arg Thr Thr Asn Gly Arg Leu Asn Ile Asp Asn Leu Asn Leu Ser
 1               5                  10                  15      
Phe Arg Lys Glu
            20  


<210> 1972
<211> 12
<212> PRT
<213> Homo sapiens

<400> 1972
Leu Gln Leu Ala Asn His Ser Gly Tyr Ile Lys Val
 1               5                  10          


<210> 1973
<211> 13
<212> PRT
<213> Homo sapiens

<400> 1973
Leu Gln Gly Leu Pro Gly Ser Ser Gly Asn Met Thr Asn
 1               5                  10              


<210> 1974
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1974
Leu Pro Leu Asn Glu Ser Ala Asp Ile Thr Phe Ala Thr Leu Asn Thr
 1               5                  10                  15      
Lys Gly Asn Glu Gly Asp Ile Val Arg Asp
            20                  25      


<210> 1975
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1975
Leu Met Gln Asn Gln Ser Ser Thr Asn His Pro Gly Ala Ser Ile Ala
 1               5                  10                  15      
Leu Ser Arg Pro Ser Leu Asn Lys Asp Phe Arg Asp
            20                  25              


<210> 1976
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1976
Leu Leu Ser Pro Asn Leu Thr Asp Glu Gln Ala Met Leu Glu Asp Thr
 1               5                  10                  15      
Leu Val Ala Leu Phe Asp Leu Glu Lys Val
            20                  25      


<210> 1977
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1977
Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala
 1               5                  10                  


<210> 1978
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1978
Leu Leu Asn Phe Ser Gln Glu Glu Glu Asn Met Leu Lys Glu
 1               5                  10                  


<210> 1979
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1979
Leu Leu Leu Leu Leu Val Leu Ala Asn Leu Thr Asp Ala Ser Asp Ala
 1               5                  10                  15      
Pro Asn Pro Tyr Arg Gln
            20          


<210> 1980
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1980
Leu Leu Lys Ala Asn Asn Thr Leu Leu Lys Met Gly Tyr His Phe Glu
 1               5                  10                  15      
Leu Pro Gly Pro Arg Met Val Val Thr Asn Leu Leu Thr Arg Asn
            20                  25                  30      


<210> 1981
<211> 10
<212> PRT
<213> Homo sapiens

<400> 1981
Leu Lys Ser Asn Asn Ser Met Ala Gln Ala
 1               5                  10  


<210> 1982
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1982
Leu Lys Arg Lys Trp Asn Ser Leu Ser Val Ile Pro Val Leu Asn Ser
 1               5                  10                  15      
Ser Ser Tyr Thr Lys Glu
            20          


<210> 1983
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1983
Leu Lys Asp Glu Asn Thr Ile Ser Pro Tyr Glu Met Cys Ser Ser Gly
 1               5                  10                  15      
Leu Val Gln Ala Leu Leu Thr Val Leu Asn Asn Val Ser Ile Phe Arg
            20                  25                  30          
Ala Thr Lys Gln
        35      


<210> 1984
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1984
Leu Ile His Ala Leu Ala Thr Asn Ser Ser Ser Glu Leu Phe Arg Leu
 1               5                  10                  15      
Ala Ala His Pro Leu Asn Asn Arg Met
            20                  25  


<210> 1985
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1985
Leu Phe Asn Ser Asn Asn Phe Asp Leu Gly Cys Lys Gln Asn Gly Thr
 1               5                  10                  15      
Lys Leu
        


<210> 1986
<211> 17
<212> PRT
<213> Homo sapiens

<400> 1986
Leu Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys
 1               5                  10                  15      
Gln
    


<210> 1987
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1987
Leu Asp Thr Cys Pro Ser Ser Ser Thr Ala Ser Ser Ile Ser Ser Ser
 1               5                  10                  15      
Gly Gly Ser Ser Gly Ser Ser Ser Asp Asn Arg Thr Tyr Arg Tyr
            20                  25                  30      


<210> 1988
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1988
Leu Ala Thr Tyr Asn Asn Ser Leu Ser Pro Leu His Ala Ser His Gln
 1               5                  10                  15      
Glu Ala Cys Arg Ser
            20      


<210> 1989
<211> 36
<212> PRT
<213> Homo sapiens

<400> 1989
Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu Val Ala Ile Leu Asn
 1               5                  10                  15      
Ser Thr Thr Ile Glu Ile Ser Glu Leu Pro Val Arg Thr Trp Thr Gln
            20                  25                  30          
Thr Tyr Lys Glu
        35      


<210> 1990
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1990
Leu Ala Leu Ala Asn Ser Ser Gln Ala Asn Asp Cys Leu Asp Ser Phe
 1               5                  10                  15      
Ala Ser Pro Asn Lys Thr
            20          


<210> 1991
<211> 29
<212> PRT
<213> Homo sapiens

<400> 1991
Lys Tyr Thr Gly Ser Gly Ile Leu Ser Met Ala Asn Ala Val Leu Asn
 1               5                  10                  15      
Thr Asn Gly Ser His Phe Phe Ile Cys Thr Ala Lys Thr
            20                  25                  


<210> 1992
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1992
Lys Tyr Thr Glu Val Thr Asp Ile Asn Ser Val Asp Ala Asn Tyr Asn
 1               5                  10                  15      
Ser Ser Val Leu Val Ser Gly Asp Asp Phe Gly Leu Val Lys Leu Phe
            20                  25                  30          
Lys Phe
        


<210> 1993
<211> 25
<212> PRT
<213> Homo sapiens

<400> 1993
Lys Tyr Arg Thr Lys Ile Glu Thr Leu Asn Phe Thr Pro Val Asp Asp
 1               5                  10                  15      
Arg Val Asp Tyr Val Thr Ala Lys Gln
            20                  25  


<210> 1994
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1994
Lys Tyr Arg Glu Thr Lys Ser Gln Glu Ser Glu Glu Leu Val Val Thr
 1               5                  10                  15      
Gly Gly Gly Gly Leu Arg Arg Phe Lys Thr Ile Glu Leu Asn Ser Thr
            20                  25                  30          
Ile
    


<210> 1995
<211> 19
<212> PRT
<213> Homo sapiens

<400> 1995
Lys Tyr Pro Glu Ser Asn Arg Thr Pro Val Lys Pro Ser Ser Val Glu
 1               5                  10                  15      
Glu Glu Asp
            


<210> 1996
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1996
Lys Tyr Asn Leu Glu Lys Asp Leu Lys Asp Lys Phe Val Ala Leu Thr
 1               5                  10                  15      
Ile Asp Asp Ile Cys Phe Ser Leu Asn Asn Asn Ser Pro Asn Ile Arg
            20                  25                  30          
Tyr
    


<210> 1997
<211> 18
<212> PRT
<213> Homo sapiens

<400> 1997
Lys Tyr Leu Cys Ile Pro Ala Ala Asp Ser Pro Ser Gln Asn Leu Thr
 1               5                  10                  15      
Arg His
        


<210> 1998
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1998
Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala Thr Lys Glu
 1               5                  10                  


<210> 1999
<211> 22
<212> PRT
<213> Homo sapiens

<400> 1999
Lys Tyr Lys Glu Leu Thr Leu Thr Arg Asn Gln Gly Ile Cys Gly Lys
 1               5                  10                  15      
Asn Asn Ser Tyr Ile Glu
            20          


<210> 2000
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2000
Lys Tyr Lys Asp Gln Trp Gly Gln Gln Gly Leu Tyr His Cys Pro Asn
 1               5                  10                  15      
Phe Ser Asp Val Met Gly Asn Lys Thr
            20                  25  


<210> 2001
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2001
Lys Tyr Glu Tyr Leu Met Thr Leu His Gly Val Val Asn Glu Ser Thr
 1               5                  10                  15      
Val Cys Leu Met Gly His Glu Arg Arg
            20                  25  


<210> 2002
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2002
Lys Tyr Glu Arg Gly Leu Ile Phe Tyr Ile Asn His Ser Leu Tyr Glu
 1               5                  10                  15      
Asn Leu Asp Glu Glu Leu Asn Glu Glu Leu Ala Ala Lys Val
            20                  25                  30  


<210> 2003
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2003
Lys Tyr Glu Ile Tyr Leu Asn Ser Ser Leu Val Gln Phe Leu Leu Ser
 1               5                  10                  15      
Arg
    


<210> 2004
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2004
Lys Tyr Asp Tyr Leu Met Thr Leu His Gly Val Val Asn Glu Ser Thr
 1               5                  10                  15      
Val Cys Leu Met Ser Tyr Glu Arg Arg Gln
            20                  25      


<210> 2005
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2005
Lys Tyr Asp Asn Ser Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr
 1               5                  10                  15      
Asn Cys Leu Ala Pro Arg Ala
            20              


<210> 2006
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2006
Lys Tyr Cys Gly Leu Gly Leu Gln Ile Asn His Ser Ile Glu Ser Lys
 1               5                  10                  15      
Gly Asn
        


<210> 2007
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2007
Lys Tyr Ala Leu Ile Ile Val Met Met Thr Ile Met Thr Ala Thr Asp
 1               5                  10                  15      
Ile Gln Leu Leu Asn Gln Thr Met Glu Asn Thr Arg Gln
            20                  25                  


<210> 2008
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2008
Lys Trp Ser Pro Thr Gly Pro Ala Thr Ser Asn Pro Asn Ser Ser Ile
 1               5                  10                  15      
Met Leu Ala Ser Ala Ser Phe Asp Ser Thr Val Arg Leu
            20                  25                  


<210> 2009
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2009
Lys Trp Ser Met Val Cys Leu Leu Met Asn Gly Ser Ser His Ser Pro
 1               5                  10                  15      
Thr Ala Ile Asn
            20  


<210> 2010
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2010
Lys Trp Ser Cys Thr Glu Ala Ser Asn Thr Ser Pro Thr Met Ser Ala
 1               5                  10                  15      
Ala Gln Asn Ala Glu
            20      


<210> 2011
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2011
Lys Trp Arg Ser Asn Thr Ser Leu Leu Gln Gln Asn Leu Arg Gln
 1               5                  10                  15  


<210> 2012
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2012
Lys Trp Arg Arg Pro Asp Tyr Asp Gly Gly Ser Pro Asn Leu Ser Tyr
 1               5                  10                  15      
His Val Glu Arg Arg Leu
            20          


<210> 2013
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2013
Lys Trp Gln Ser Ala Ile Gln Asp Phe Arg Ser Asn Ala Thr Ala Leu
 1               5                  10                  15      
Cys His Ile Arg Asn
            20      


<210> 2014
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2014
Lys Trp Asn Phe Ser Ser Gly Phe Ile Glu Ala Val Phe Lys His
 1               5                  10                  15  


<210> 2015
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2015
Lys Trp Met Leu Lys Thr Gly Met Lys Asn Asn Ala Thr Lys Gln
 1               5                  10                  15  


<210> 2016
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2016
Lys Trp Leu Pro Asn Ser Thr Thr Thr Cys Ser Leu Ser Pro Asp Ser
 1               5                  10                  15      
Ala Ile Leu
            


<210> 2017
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2017
Lys Trp Ile His Thr Leu Thr Ser Leu Leu Gln Asn Ile Ser Ser Tyr
 1               5                  10                  15      
Tyr Thr Ser Leu Pro Arg Phe
            20              


<210> 2018
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2018
Lys Val Tyr Glu Asn Thr Thr Leu Gly Phe Ile Val Glu Val Glu Gly
 1               5                  10                  15      
Leu Pro Val Pro Gly Val
            20          


<210> 2019
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2019
Lys Val Thr Arg Asp Ala Leu Thr Glu Pro Leu Ala Ile Val Glu Gly
 1               5                  10                  15      
Tyr Asn Ser Tyr Phe Ser Phe Ser Arg Asn Arg Ser
            20                  25              


<210> 2020
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2020
Lys Val Thr Cys Asp Ile Asp Val Asn Ser Ser Leu Asn Ile Ser Ala
 1               5                  10                  15      
Val Gly Lys Ser Thr Glu Lys Glu
            20                  


<210> 2021
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2021
Lys Val Ser Ser Pro Leu Glu Asn Glu Lys Leu Lys Ser Met Thr Ile
 1               5                  10                  15      
Asn Phe Ser Ser Leu Asn Arg Lys
            20                  


<210> 2022
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2022
Lys Val Ser Asn Leu Ser Leu Phe Gly Gly Leu Pro Ala Asn His Val
 1               5                  10                  15      
Leu Val Asn Gln Tyr Leu Pro Gly
            20                  


<210> 2023
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2023
Lys Val Arg Arg Pro Ser Pro Asn Arg Ser Lys Leu Ser Asn Val Ala
 1               5                  10                  15      
Arg Lys Ala
            


<210> 2024
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2024
Lys Val Asn Arg Tyr Asp Ala Gly Lys Tyr Thr Ile Glu Ala Glu Asn
 1               5                  10                  15      
Gln Ser Gly Lys Lys Ser
            20          


<210> 2025
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2025
Lys Val Asn Ala Pro Ile Leu Thr Asn Thr Thr Leu Asn Val Ile Arg
 1               5                  10                  15      
Leu
    


<210> 2026
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2026
Lys Val Asn Pro Thr Leu Val Ile Gln Pro Thr Asn Leu Ser Ala Arg
 1               5                  10                  15      
Leu Glu Thr Asp Val Glu Cys Leu Lys Leu
            20                  25      


<210> 2027
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2027
Lys Val Asn Asn Ser Gly Ile Ser Leu Cys Asn Leu Ile Ser Ala Val
 1               5                  10                  15      
Thr Thr Pro Ala Lys Ala Ile Ala Ala Val Lys Ser
            20                  25              


<210> 2028
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2028
Lys Val Asn Lys Thr Leu Thr Ser Leu Asn Ile Glu Ser Asn Phe Ile
 1               5                  10                  15      
Thr Gly Thr Gly Ile Leu Ala Leu Val Glu Ala Leu Lys Glu
            20                  25                  30  


<210> 2029
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2029
Lys Val Leu Thr Pro Glu Glu Leu Leu Tyr Arg Ala Val Gln Ser Val
 1               5                  10                  15      
Asn Val Thr His Asp Ala Val His Ala
            20                  25  


<210> 2030
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2030
Lys Val Leu Glu Ala Asn Ala Thr Pro Leu Asp Arg Gly Asp Gly Val
 1               5                  10                  15      
Leu Arg Thr Cys Ala Leu Arg Pro
            20                  


<210> 2031
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2031
Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr Ile
 1               5                  10                  15      
Ala Lys Leu Thr Lys Glu
            20          


<210> 2032
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2032
Lys Val Lys Met Val Val Ser Arg Glu Glu Val Glu Leu Ala Tyr Gln
 1               5                  10                  15      
Glu Ala Met Phe Asn Met Ala Thr Leu Asn Arg Thr Ala Ala Gly Leu
            20                  25                  30          
Met His Thr Phe
        35      


<210> 2033
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2033
Lys Val Ile Gln Met Asp Val Ala Leu Phe Glu Met Asn Gln Ser Asp
 1               5                  10                  15      
Ser Lys Glu
            


<210> 2034
<211> 36
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 15
<223> Xaa = Any Amino Acid

<400> 2034
Lys Val His Thr Gly Thr His Met Trp Asn Ser Thr Pro Val Xaa Gln
 1               5                  10                  15      
Gly Arg Gln Leu Ser Gly Asp Gly Pro Met Thr Phe Leu Gly Gly Asn
            20                  25                  30          
Pro Ile Lys Phe
        35      


<210> 2035
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2035
Lys Val Gly Ala Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Asp Asp
 1               5                  10                  15      
Thr Phe Asn Val Ser Ile Leu Thr Thr Glu Asp Gly Ile Phe Glu Val
            20                  25                  30          
Lys Ser
        


<210> 2036
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2036
Lys Val Asp Ser Asn Asp Ser Leu Tyr Gly Gly Asp Ser Lys Phe Leu
 1               5                  10                  15      
Ala
    


<210> 2037
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2037
Lys Val Asp Pro Glu Thr Asn Lys Asn Ile Thr Arg Gly Gln Ser Leu
 1               5                  10                  15      
Asp Asn Leu Ile Lys Val
            20          


<210> 2038
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2038
Lys Val Asp Met His Asp Asp Ser Leu Asn Thr Thr Ala Asn Leu Ile
 1               5                  10                  15      
Trp Asn Lys Leu
            20  


<210> 2039
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2039
Lys Val Ala Arg Leu Glu Gln Asn Gly Ser Pro Met Gly Ala Arg Gly
 1               5                  10                  15      
Arg Pro Asn Gly Ala Val Ala Lys Ala
            20                  25  


<210> 2040
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2040
Lys Val Ala Pro Val Ile Asn Asn Gly Ser Pro Thr Ile Leu Gly Lys
 1               5                  10                  15      
Arg Ser
        


<210> 2041
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2041
Lys Val Ala Gly Ser Glu Glu Asn Gly Thr Ala Glu Thr Glu Glu Val
 1               5                  10                  15      
Glu Asp Glu Ser Ala Ser Gly Glu Leu Asp Leu Glu Ala Gln Phe His
            20                  25                  30          
Leu His Phe
        35  


<210> 2042
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2042
Lys Val Ala Asp Arg Thr Lys Ser Glu Asn Gly Leu Gln Asn Glu Ser
 1               5                  10                  15      
Leu Ser Ser Thr His His Thr Asp Gly Leu Ser Lys Ile
            20                  25                  


<210> 2043
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2043
Lys Thr Tyr Trp Glu Ser Asn Gly Ser Ala Gly Ser His Tyr Ile Thr
 1               5                  10                  15      
Leu His Met Arg Arg Gly
            20          


<210> 2044
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2044
Lys Thr Val Asn Leu Ser Val Thr Pro Ser Pro Ala Pro Arg Thr
 1               5                  10                  15  


<210> 2045
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2045
Lys Thr Thr Thr Arg Gln Leu Ser Ser Pro Asn His Ser Pro Ser Gln
 1               5                  10                  15      
Ser Pro Asn Gln Ser Pro Arg Ile
            20                  


<210> 2046
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2046
Lys Thr Ser Ile Ala Gln Ser Val Leu Gln Ser Leu Pro Ser Ser Gln
 1               5                  10                  15      
Trp Ser Val Leu Val Val Asn Met Ser Ala Gln Thr
            20                  25              


<210> 2047
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2047
Lys Thr Arg Pro Gln Asn Gly Ser Met Ile Leu Tyr Asn Arg Lys Lys
 1               5                  10                  15      


<210> 2048
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2048
Lys Thr Arg Gly Arg Gly Ala Ala Asn Asp Ser Thr Gln Phe Thr Val
 1               5                  10                  15      
Ala Gly Arg Met Val Lys Lys Gly
            20                  


<210> 2049
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2049
Lys Thr Gln Leu Asn Ser Ser Ser Leu Gln Lys Leu Phe Arg Glu
 1               5                  10                  15  


<210> 2050
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2050
Lys Thr Asn Asn Val Asn Val Ser Ser Arg Val
 1               5                  10      


<210> 2051
<211> 38
<212> PRT
<213> Homo sapiens

<400> 2051
Lys Thr Asn Leu Asp Asp Asp Val Pro Ile Leu Leu Phe Glu Ser Asn
 1               5                  10                  15      
Gly Ser Leu Ile Tyr Thr Pro Thr Ile Glu Ile Asn Ser Ser His His
            20                  25                  30          
Ser Ala Met Glu Lys Arg
        35              


<210> 2052
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2052
Lys Thr Asn Glu Ile Ser Val Ile Gln Ser Gly Gly Val Pro Thr Leu
 1               5                  10                  15      
Pro Val Ser Leu Gly Ala Thr Ser Val Val Asn Asn Ala Thr Val Ser
            20                  25                  30          
Lys Met
        


<210> 2053
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2053
Lys Thr Asn Val Thr His Glu Glu His Thr Ala Val Glu Lys Ile
 1               5                  10                  15  


<210> 2054
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2054
Lys Thr Asn Arg Ser Ser Val Lys Thr Pro Lys Pro Val Glu Pro Ala
 1               5                  10                  15      
Ala Ser Asp Leu Glu Pro
            20          


<210> 2055
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2055
Lys Thr Asn Gly Thr Leu Leu Arg Asn Gly Gly Leu Pro Gly Gly Pro
 1               5                  10                  15      
Asn Lys Ile Pro Asn Gly Asp Ile Cys Cys Ile Pro Asn Ser Asn Leu
            20                  25                  30          
Asp Lys Ala
        35  


<210> 2056
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2056
Lys Thr Met Ser Ile Val Ser Tyr Asn His Leu Gly Asn Asn Asp Gly
 1               5                  10                  15      
Glu Asn Leu Ser Ala Pro Leu Gln Phe Arg Ser
            20                  25          


<210> 2057
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2057
Lys Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr
 1               5                  10                  15      
Gly Pro Ala His Gln Pro Gly Arg Gly
            20                  25  


<210> 2058
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2058
Lys Thr Leu Pro Asp Ser Ala Gly Tyr Val Glu Gly Leu Gln Cys Met
 1               5                  10                  15      
Ser Val Glu Asn Ala Thr Thr Ile Arg Thr
            20                  25      


<210> 2059
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2059
Lys Thr Leu Asp Leu Gln Ser Gly Leu Lys Asp Ile Thr Gly Asn Lys
 1               5                  10                  15      
Ser Glu Met Ile Glu Lys Pro
            20              


<210> 2060
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2060
Lys Thr His Met Asn Val Leu Gly Val Leu Gly Pro Leu Asp Pro Gln
 1               5                  10                  15      
Trp Leu Val Glu Asn Asn Ile Thr Gly Cys Pro
            20                  25          


<210> 2061
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2061
Lys Thr Gly Thr Thr Leu Asn Thr Ser Ile Ile Phe Gly Pro Asn Leu
 1               5                  10                  15      
Ser
    


<210> 2062
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2062
Lys Thr Phe Val Glu Val Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala
 1               5                  10                  15      
Thr Gly Ala Val Val Ser Glu Arg Ser Leu Arg Ser
            20                  25              


<210> 2063
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2063
Lys Thr Phe Thr Met Met Gly Pro Ser Glu Ser Asp Asn Phe Ser His
 1               5                  10                  15      
Asn Leu Arg Gly
            20  


<210> 2064
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2064
Lys Thr Phe Ala Asn Ser Ser Tyr Leu Ala Gln His Ile Arg Ile
 1               5                  10                  15  


<210> 2065
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2065
Lys Thr Glu Pro Met Asp Ala Asp Asp Ser Asn Asn Cys Thr Gly
 1               5                  10                  15  


<210> 2066
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2066
Lys Ser Trp Asn Lys Ser Gln Asn Asp Cys Ala Ile Asn Asn Ser Tyr
 1               5                  10                  15      
Leu Met Val Ile Gln Asp Ile Thr Ala Met Val Arg Phe
            20                  25                  


<210> 2067
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2067
Lys Ser Val Asn Val Ser Ser Asn Leu Val Thr Gln Glu Pro Ser Pro
 1               5                  10                  15      
Glu Glu Thr Ser Thr Lys Arg Ser
            20                  


<210> 2068
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2068
Lys Ser Thr Asn Ile Ser Phe Thr Asp Met Val Ser Ala Asp Glu Arg
 1               5                  10                  15      
Leu
    


<210> 2069
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2069
Lys Ser Thr Lys Pro Ile Val Ala Ala Ile Asn Gly Ser Cys Leu Gly
 1               5                  10                  15      
Gly Gly Leu Glu Val Ala Ile Ser Cys Gln Tyr Arg Ile
            20                  25                  


<210> 2070
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2070
Lys Ser Ser Ser Thr Pro Phe Pro Phe Arg Thr Gly Leu Thr Ser Gly
 1               5                  10                  15      
Asn Val Thr Glu Asn Leu Gln Thr Tyr Ile Asp Lys Ser
            20                  25                  


<210> 2071
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2071
Lys Ser Ser Ser Ser Leu Gly Asn Ala Thr Ser Asp Glu Asp Pro Asn
 1               5                  10                  15      
Thr Asn Ile Met Asn Ile Asn Glu Asn Lys Asn
            20                  25          


<210> 2072
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2072
Lys Ser Ser Asn Leu Ser Glu His Gln Thr Leu His Thr Gly Gln Arg
 1               5                  10                  15      
Pro
    


<210> 2073
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2073
Lys Ser Ser Leu Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser
 1               5                  10                  15      
Asp Ser Glu Ala Glu Arg Arg Pro
            20                  


<210> 2074
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2074
Lys Ser Ser Leu Ser Ala Ser Thr Asn Pro Glu Leu Gly Ser Asn Val
 1               5                  10                  15      
Ser Gly Thr Gln Thr Tyr Pro Val Val Thr Gly Arg Asp
            20                  25                  


<210> 2075
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2075
Lys Ser Pro Thr Ser Pro Thr Gln Asn Leu Phe Pro Ala Ser Lys Thr
 1               5                  10                  15      
Ser Pro Val Asn Leu Pro Asn Lys Ser Ser Ile Pro
            20                  25              


<210> 2076
<211> 38
<212> PRT
<213> Homo sapiens

<400> 2076
Lys Ser Pro Ile Ile Pro Glu Cys Ser Thr Asn Val Gln Thr Ala Ala
 1               5                  10                  15      
Gly Gly Ser Asn Ser Ser Gln Tyr Asn Ser Asn Leu Thr Ile Arg Leu
            20                  25                  30          
Ser Val Ser Trp Lys Gly
        35              


<210> 2077
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2077
Lys Ser Pro Asp Thr Phe Met Ile Pro Met Ala Leu Pro Asn Asp Asn
 1               5                  10                  15      
Gly Ser Val Ser Gly Val
            20          


<210> 2078
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2078
Lys Ser Met Ile Asn Thr Thr Gly Ala Val Asp Ser Gly Ser Ser Ser
 1               5                  10                  15      
Ser Ser Ser Ser Ser Ser Phe Val Asn Gly Ala Thr Ser Lys Asn
            20                  25                  30      


<210> 2079
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2079
Lys Ser Leu Thr Thr Glu Cys His Leu Leu Asp Ser Pro Gly Leu Asn
 1               5                  10                  15      
Cys Ser Asn Pro Phe Thr Gln Leu Glu Arg Arg
            20                  25          


<210> 2080
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2080
Lys Ser Leu Thr Asn Leu Ser Gln Glu Glu Gln Ile Thr Lys Leu Leu
 1               5                  10                  15      
Ile Leu Lys Leu
            20  


<210> 2081
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2081
Lys Ser Leu Asn Asp Ser Ile Gln Pro Asp Pro Leu Cys Leu His Asn
 1               5                  10                  15      
Ser Ser Leu Phe Ala Leu Gln Asn Leu Gln Pro Trp
            20                  25              


<210> 2082
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2082
Lys Ser Leu Ile Glu Gly Val Ile Ser Gly Tyr Asn Ala Thr Val Phe
 1               5                  10                  15      
Ala Tyr Gly Pro Thr Gly Cys Gly Lys Thr
            20                  25      


<210> 2083
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2083
Lys Ser Lys Ser Asp Leu Ala Val Ser Asn Ile Ser Pro Pro Ser Pro
 1               5                  10                  15      
Asp Ser Lys Ser
            20  


<210> 2084
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2084
Lys Ser Ile Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu
 1               5                  10                  15      
Glu
    


<210> 2085
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2085
Lys Ser Ile His Glu Gln Asp Thr Asn Val Asn Asn Ser Val Leu Lys
 1               5                  10                  15      
Lys Val
        


<210> 2086
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2086
Lys Ser Ile Gly Pro Glu His Asn Gly Ser Met Val Arg Asn Lys Cys
 1               5                  10                  15      


<210> 2087
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2087
Lys Ser Ile Glu Asn Asp Ser Asp Glu Val Glu Glu Arg Ala Glu Asn
 1               5                  10                  15      
Phe Pro Arg Thr
            20  


<210> 2088
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2088
Lys Ser His Ile Ser Asn His Thr Ala Leu Glu Asn Cys Val Ser Leu
 1               5                  10                  15      
Leu Cys Ile Arg Ala Asp Glu Leu Gln
            20                  25  


<210> 2089
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2089
Lys Ser Gly Lys Leu Asn Ile Gly Asp Gln Ile Met Ser Ile Asn Gly
 1               5                  10                  15      
Thr Ser Leu Val Gly Leu Pro Leu Ser Thr Cys Gln Ser Ile Ile Lys
            20                  25                  30          
Gly
    


<210> 2090
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2090
Lys Ser Phe Asn Cys Asn Ser Ser Leu Ile Lys His Trp Arg Val His
 1               5                  10                  15      
Thr Gly Glu Arg Pro
            20      


<210> 2091
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2091
Lys Ser Phe Leu Asn Ala Phe Ser Glu Glu Ile Asn Asn Ser Met Ile
 1               5                  10                  15      
Ile Leu Ser Leu Ser Pro Thr Thr Phe Lys Asn
            20                  25          


<210> 2092
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2092
Lys Ser Phe Gly Ser Pro Pro Leu Ala Val Ser Asn Val Ser Ala Ala
 1               5                  10                  15      
Val Met Val Leu Met Ala Pro Arg Gly Arg
            20                  25      


<210> 2093
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2093
Lys Ser Glu Val Asn Glu Met Glu Asn Asn Leu Thr Arg Arg Arg
 1               5                  10                  15  


<210> 2094
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2094
Lys Ser Glu His Asn Pro Ser Thr Ser Gly Cys Ser Ser Asp Gln Ser
 1               5                  10                  15      
Ser Lys Val
            


<210> 2095
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2095
Lys Ser Glu Glu Asn Ser Thr Val Phe Ser His Leu Met Lys Tyr
 1               5                  10                  15  


<210> 2096
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2096
Lys Ser Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly
 1               5                  10              


<210> 2097
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2097
Lys Ser Cys Ser Ser His Ser Ser Ser Asn Thr Leu Ser Ser Asn Thr
 1               5                  10                  15      
Ser Ser Asn Ser Asp Asp Lys His
            20                  


<210> 2098
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2098
Lys Arg Tyr Asn Gln Ser Met Val Thr Ala Glu Leu Gln Arg Leu
 1               5                  10                  15  


<210> 2099
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2099
Lys Arg Tyr Glu Asp Gly Thr Ile Ser Ser Asn Ala Thr His Val Glu
 1               5                  10                  15      
His Pro Leu Cys Pro Pro Lys Pro
            20                  


<210> 2100
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2100
Lys Arg Thr Ile Asn Ser Ser Gln Glu Pro Ala Pro Gly Met Lys Pro
 1               5                  10                  15      
Asn Trp Pro Arg Ser Arg Tyr
            20              


<210> 2101
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2101
Lys Arg Ser Pro Ile Phe Phe Asn Tyr Leu Tyr Ser Pro Leu Glu Ile
 1               5                  10                  15      
Glu Ala Leu Lys Pro Asn Val Asn Val Ser Ser Leu Lys Lys
            20                  25                  30  


<210> 2102
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2102
Lys Arg Ser His Asn Ala Ser Ile Ile Asp Met Gly Glu Glu
 1               5                  10                  


<210> 2103
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2103
Lys Arg Ser Gly Val Lys Thr Ser Gly Ser Glu Gly Ser Ala Pro Ile
 1               5                  10                  15      
Asn Asn Ser Val Ile
            20      


<210> 2104
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2104
Lys Arg Arg Thr Thr Asn Arg Thr Ile Pro Ser Val Asp Asp Phe Gln
 1               5                  10                  15      
Asn Tyr Leu Arg Val Ala Phe Gln Glu Val Asn Ser Gly Cys Thr Gly
            20                  25                  30          
Lys Thr
        


<210> 2105
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2105
Lys Arg Arg Lys Glu Leu Gly Ala Met Ala Phe Ser Thr Thr Ala Ile
 1               5                  10                  15      
Asn Phe Ser Thr Val Asn Ser Ser Ala Gly Phe Arg Ser
            20                  25                  


<210> 2106
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2106
Lys Arg Gln Ala Glu Glu Ala Glu Glu Gln Ser Asn Ala Asn Leu Ser
 1               5                  10                  15      
Lys Phe Arg Lys
            20  


<210> 2107
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2107
Lys Arg Pro Asn Glu Asn Ser Ser Ala Asp Ile Ser Gly Lys Thr
 1               5                  10                  15  


<210> 2108
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2108
Lys Arg Pro Glu Thr Lys Leu Lys Pro Leu Pro Val Ala Pro Ser Gln
 1               5                  10                  15      
Pro Thr Leu Gly Ser Ser Asn Ile Asn Gly Ser Ile Asp Tyr Pro Ala
            20                  25                  30          
Lys Asn
        


<210> 2109
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2109
Lys Arg Asn Thr Glu Leu Glu Thr Leu Leu Ala Lys Leu Ile Gln Thr
 1               5                  10                  15      
Cys Gln His Val Glu Val Asn Ala Ser Arg Gln
            20                  25          


<210> 2110
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2110
Lys Arg Asn His Met Leu Leu Leu Tyr Pro Arg Glu Ile Leu Ile Leu
 1               5                  10                  15      
Asp Leu Glu Val Asn Gln Thr Val Gly Val Ile Ala Ile Glu Arg Thr
            20                  25                  30          
Gly Val Pro
        35  


<210> 2111
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2111
Lys Arg Asn Ser Ser Ser Ser Ser Thr Asp Ser Glu Thr Leu Arg Tyr
 1               5                  10                  15      
Asn His Asn Phe Glu Pro Lys Ser
            20                  


<210> 2112
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2112
Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu Gly Leu Gln
 1               5                  10                  15      
Glu Leu Lys Arg
            20  


<210> 2113
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2113
Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn
 1               5                  10                  15      
Leu Thr Glu Leu Val Pro Gln His Lys Ala
            20                  25      


<210> 2114
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2114
Lys Arg Phe Glu Ile Ser Cys Asn Leu Ser Leu Asp Ala Met Glu Glu
 1               5                  10                  15      
Phe Leu Asn Arg Arg Lys Met
            20              


<210> 2115
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2115
Lys Arg Ala Asp Lys Tyr Trp Glu Tyr Thr Phe Lys Val Asn Trp Ser
 1               5                  10                  15      
Asp Leu Ser Val Thr Thr Val Thr Lys Thr
            20                  25      


<210> 2116
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2116
Lys Gln Val Pro Leu Ile Pro Asp Leu Asn Gln Thr
 1               5                  10          


<210> 2117
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2117
Lys Gln Val Leu Leu Phe Asn Asn Ser His Leu Thr Tyr Val Ser Phe
 1               5                  10                  15      
Asp Phe His Glu His Cys Arg Gly
            20                  


<210> 2118
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2118
Lys Gln Ser Ser Asn Arg Pro Ala His Asn Ile Ser His Ile Leu Gly
 1               5                  10                  15      
His Asp Cys Ser Ser Ala Val
            20              


<210> 2119
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2119
Lys Gln Gln Phe Asn Thr Gln Asn Gln Ser Asn Val Met Pro Gly Pro
 1               5                  10                  15      
Ala Gln Ile Met Arg Gly Pro Thr Pro Asn Met
            20                  25          


<210> 2120
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2120
Lys Gln Pro Val Glu Ser Ser Glu Asp Ser Thr Asp Asp Ser Asn Ser
 1               5                  10                  15      
Ser Ser Gly Glu Glu Glu Arg
            20              


<210> 2121
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2121
Lys Gln Asn Ser Asp His Ser Asn Gly Ser Phe Asn Leu Lys Ala Leu
 1               5                  10                  15      


<210> 2122
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2122
Lys Gln Asn Ser Ala Tyr Asn Met His Ser Ile Leu Ser Asn Thr Ser
 1               5                  10                  15      
Ala Glu
        


<210> 2123
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2123
Lys Gln Asn Pro Met Ala Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met
 1               5                  10                  15      
Asp His Ser Ile Ser Pro Phe Met Arg Lys
            20                  25      


<210> 2124
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2124
Lys Gln Asn Asn Thr Asn Ala Asn Lys Pro Lys Lys
 1               5                  10          


<210> 2125
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2125
Lys Gln Asn Asn Ser Tyr Trp Arg Glu
 1               5                  


<210> 2126
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2126
Lys Gln Asn Lys Ser Pro Asp Thr Glu Lys Ile Asn Tyr Ala Gly Pro
 1               5                  10                  15      
Leu Glu Glu Thr Gly Ile Ser Asp Ile Thr Lys Lys Glu Lys Glu
            20                  25                  30      


<210> 2127
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2127
Lys Gln Met Leu Ile Val Ile Thr Asp Gly Glu Ser His Asp His Asp
 1               5                  10                  15      
Gln Leu Asn Asp Thr Ala Leu Glu Leu Arg Asn Lys Gly
            20                  25                  


<210> 2128
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2128
Lys Gln Leu Gly Ser Phe Pro Ser Asn Tyr Leu Ser Asn Asn Asn Gln
 1               5                  10                  15      
Thr Ser
        


<210> 2129
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2129
Lys Gln Lys Ser Leu Thr Asn Leu Ser Phe Leu Thr Asp Ser Glu Lys
 1               5                  10                  15      
Lys Leu
        


<210> 2130
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2130
Lys Gln Lys Pro Ser Gly Leu Thr Arg Ser Thr Ser Met Leu Ile Ser
 1               5                  10                  15      
Ser Gly His Asn Lys Ser Ser Asn Ser Leu Lys Leu
            20                  25              


<210> 2131
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2131
Lys Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser
 1               5                  10                  15      
Ser Gly His Arg Val Arg Leu
            20              


<210> 2132
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2132
Lys Gln Ile Lys Asn Ser Ser Leu Leu Ser Phe Asp Asn Glu Asp Glu
 1               5                  10                  15      
Asn Glu
        


<210> 2133
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2133
Lys Gln His Gly Val Asn Val Ser Val Asn Ala Ser Ala Thr Pro Phe
 1               5                  10                  15      
Gln Gln Pro Ser Gly Tyr
            20          


<210> 2134
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2134
Lys Gln Gly Ala Glu Asn Met Thr His Thr Cys Ala Ser Gly Thr Pro
 1               5                  10                  15      
Lys Glu Arg Lys
            20  


<210> 2135
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2135
Lys Gln Glu Asn Ser Ser Asn Ser Ser Pro Ala Pro Glu Pro Asn Ser
 1               5                  10                  15      
Ala Val Pro Ser Asp Gly Thr Glu Ala Lys Val
            20                  25          


<210> 2136
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2136
Lys Pro Leu Gly Pro Leu Gln Thr Leu Met Glu Asn Leu Ser Ser Asn
 1               5                  10                  15      
Arg Phe
        


<210> 2137
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2137
Lys Asn Tyr Asn Asp His Glu Asn Asn Leu Ser Ala Ile Cys Leu Val
 1               5                  10                  15      
Lys Leu
        


<210> 2138
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2138
Lys Asn Thr Asn Gln Gly Phe Ser Ser Ala Asn Val Ser Glu Glu Glu
 1               5                  10                  15      
Glu Arg Lys
            


<210> 2139
<211> 43
<212> PRT
<213> Homo sapiens

<400> 2139
Lys Asn Ser Leu Ser Gly Ile Ala Met Asn Val Pro Ala Ser Arg Gly
 1               5                  10                  15      
Ser Asn Leu Asn Ser Ser Gly Ala Asn Arg Thr Ser Leu Ser Gly Gly
            20                  25                  30          
Thr Gly Ser Gly Thr Gln Gly Ala Thr Lys Pro
        35                  40              


<210> 2140
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2140
Lys Asn Ser Asp Phe Tyr Met Gly Ala Gly Gly Pro Leu Glu His Val
 1               5                  10                  15      
Met Glu Thr Leu Asp Asn Glu Ser Phe Tyr Ser Lys Ala
            20                  25                  


<210> 2141
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2141
Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val Ser Asn Phe Lys
 1               5                  10                  15      
Arg Phe
        


<210> 2142
<211> 39
<212> PRT
<213> Homo sapiens

<400> 2142
Lys Asn Gln Glu Leu Lys Ala Gly Thr Ser Ile Met Gly Ser His Leu
 1               5                  10                  15      
Thr Ser Ala Glu Thr Val Thr Leu Asp Ser Leu Lys Ala Val Glu Val
            20                  25                  30          
Val Asn Leu Ser Val Ser Cys
        35                  


<210> 2143
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2143
Lys Asn Asn Tyr Gly Leu Leu Leu Asn Glu Asn Glu Ser Leu Phe Leu
 1               5                  10                  15      
Met Val Val Leu Trp Lys Ile
            20              


<210> 2144
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2144
Lys Asn Asn Arg Ser Asp Met Met Ser Ala Leu Gly Leu Gly Gln Glu
 1               5                  10                  15      
Glu Asp Ile Glu Ser Pro Trp Asp Ser Glu Ser Ile Ser Glu Asn Phe
            20                  25                  30          
Pro Gln Lys Tyr
        35      


<210> 2145
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2145
Lys Asn Asn Lys Ser Asp Thr Leu Pro Leu Ala Thr Arg Tyr Asn Val
 1               5                  10                  15      


<210> 2146
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2146
Lys Asn Met Leu Val Leu Asn Leu Ser His Asn Ser Ile Asp Thr Ile
 1               5                  10                  15      
Pro Asn Gln Leu Phe Ile Asn Leu Thr Asp Leu Leu Tyr Leu Asp Leu
            20                  25                  30          
Ser Glu Asn Arg Leu
        35          


<210> 2147
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2147
Lys Asn Met Ala Gln Glu Thr Asn Gln Thr Pro Gly Pro Met Leu Cys
 1               5                  10                  15      
Ser Thr Gly Cys Gly Phe Tyr Gly Asn
            20                  25  


<210> 2148
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2148
Lys Asn Leu Pro Phe Leu Glu His Leu Glu Leu Ile Gly Ser Asn Phe
 1               5                  10                  15      
Ser Ser Ala Met Pro Arg Asn
            20              


<210> 2149
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2149
Lys Asn Lys Ile Ser Ile Glu Asp Leu Leu Gln Ser Ser Met Gly Ser
 1               5                  10                  15      
Thr Gln Gln Ala Gln Asn Thr Thr Ser Ser Leu Met Asn Leu Val Met
            20                  25                  30          
Gln Phe Arg Lys
        35      


<210> 2150
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2150
Lys Asn Lys Ala Gln Asn Ile Thr Ala Pro Glu Ser Glu Ala Ile Cys
 1               5                  10                  15      
Trp Gln Leu
            


<210> 2151
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2151
Lys Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn
 1               5                  10                  15      
Leu Ala Arg Gln
            20  


<210> 2152
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2152
Lys Asn Ile Phe Val Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser
 1               5                  10                  15      
Val Ser
        


<210> 2153
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2153
Lys Asn Gly Gln Ser Leu Gly Asp Leu Asp Gly Ile Pro Ile Ala Val
 1               5                  10                  15      
Lys Asp Asn Phe Ser Thr Ser Gly Ile Glu Thr Thr Cys Ala Ser Asn
            20                  25                  30          
Met Leu Lys Gly
        35      


<210> 2154
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2154
Lys Asn Phe Ile Asn Gln Gly Pro Tyr Glu Asn Arg Ser Met Phe Glu
 1               5                  10                  15      
Ser Leu Asp Leu Ser Trp Lys Leu
            20                  


<210> 2155
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2155
Lys Asn Phe His Ser Met Gln Asn Leu Cys Pro Pro Gln Thr Asn Gly
 1               5                  10                  15      
Thr Pro Glu Gly Arg Gln
            20          


<210> 2156
<211> 39
<212> PRT
<213> Homo sapiens

<400> 2156
Lys Asn Phe Ala Gln Asn Arg Gly Ala Gly Asn Thr Ser Ser Leu Asn
 1               5                  10                  15      
Pro Leu Ala Val Gly Phe Val Gln Thr Pro Pro Val Ile Ser Ser Ala
            20                  25                  30          
His Ile Gln Asp Glu Arg Val
        35                  


<210> 2157
<211> 38
<212> PRT
<213> Homo sapiens

<400> 2157
Lys Asn Glu Asn Ser Ser Glu Gln Leu Asp Val Asp Gly Asp Ser Ser
 1               5                  10                  15      
Ser Glu Val Ser Ser Glu Val Asn Phe Asn Tyr Glu Tyr Ala Gln Met
            20                  25                  30          
Glu Val Thr Met Lys Ala
        35              


<210> 2158
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2158
Lys Asn Glu Asn Glu Thr Ile Leu Asn Pro Glu Glu Val Ala Leu Leu
 1               5                  10                  15      
Glu Glu Tyr Ile Pro Thr Arg His
            20                  


<210> 2159
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2159
Lys Asn Glu Lys Asn Gly Thr Asp Glu Leu Asp Asn Met Asn Ser Thr
 1               5                  10                  15      
Glu Arg Ile Ser Phe Leu Gln Glu Lys Leu Gln Glu Ile Arg Lys Tyr
            20                  25                  30          


<210> 2160
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2160
Lys Asn Glu Ile Gln Ser Phe Leu Val Ser Asp Pro Glu Asn Thr Thr
 1               5                  10                  15      
Trp Ala Asp Ile Glu Ala Met Val Ser Val Thr Leu
            20                  25              


<210> 2161
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2161
Lys Asn Cys Arg Asn Lys Ser Leu Leu Arg Ser Arg Arg Thr
 1               5                  10                  


<210> 2162
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2162
Lys Asn Cys Asn Thr Ser Gly Ile Gln Thr Glu Trp Ser Pro Pro Leu
 1               5                  10                  15      
Thr Met Leu Phe Leu Cys Ala Thr Lys Phe
            20                  25      


<210> 2163
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2163
Lys Asn Ala Pro Gln Asn Ser Thr Gln Ala His Ser Glu Asn Lys Cys
 1               5                  10                  15      


<210> 2164
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2164
Lys Asn Tyr Thr Ser Val Tyr Asp Lys Asn Asn Leu Leu Thr Asn Lys
 1               5                  10                  15      
Thr Val Met Ala His Gly Cys Tyr Leu
            20                  25  


<210> 2165
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2165
Lys Asn Trp Thr Phe Gly Pro Gln Asp Val Asp Glu Leu Ile Phe Met
 1               5                  10                  15      
Leu Ser Asp Ser Pro Gly Val Met Cys Arg Pro
            20                  25          


<210> 2166
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2166
Lys Asn Val Thr Leu Glu Glu Asp Gly Thr Arg Ala Val Arg Ala Ala
 1               5                  10                  15      
Gly Tyr Ala His Gly Leu Val Phe Ser Thr Lys Glu
            20                  25              


<210> 2167
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2167
Lys Asn Thr Ser Asn Lys Glu Ile Ser Arg Asp Thr Leu Leu Thr Ile
 1               5                  10                  15      
Glu Asn Asn Pro Cys
            20      


<210> 2168
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2168
Lys Asn Ser Ser Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn
 1               5                  10                  15      
Glu Lys Lys
            


<210> 2169
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2169
Lys Asn Ser Ser Glu Phe Pro Leu Phe Ser Tyr Asn Asn Gly Val Val
 1               5                  10                  15      
Met Thr Ser Cys Arg Glu
            20          


<210> 2170
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2170
Lys Asn Gln Ser Ala Ser Pro Pro Pro Lys Asp Arg Ser Ser Ser Pro
 1               5                  10                  15      
Ala Thr Glu Gln Ser Trp Thr Gln Asn
            20                  25  


<210> 2171
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2171
Lys Asn Pro Thr Asp Ala Cys Leu Asp Ala Val Met Asn Glu Ala Pro
 1               5                  10                  15      
Gly Pro Ile Asn Phe Thr Met Leu Leu Ala Met Phe Gly Lys Lys Leu
            20                  25                  30          


<210> 2172
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2172
Lys Asn Asn Thr Ile Cys Pro Gly Ala Leu Arg Phe
 1               5                  10          


<210> 2173
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2173
Lys Asn Asn Thr Ile Ala Pro Lys Lys Ala
 1               5                  10  


<210> 2174
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2174
Lys Asn Met Ser Val Thr Phe Ala Leu Asp Glu Pro Met Lys Glu Gly
 1               5                  10                  15      
Glu Cys Ser Arg Arg
            20      


<210> 2175
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2175
Lys Asn Leu Thr Gln Ser His Ser Thr Thr Trp Lys Leu Asn Asn Leu
 1               5                  10                  15      
Leu Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala
            20                  25                  


<210> 2176
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2176
Lys Asn Leu Thr Phe Asn Pro Pro Ile Tyr
 1               5                  10  


<210> 2177
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2177
Lys Asn Leu Thr Ala Val Lys Ser Gly Gly Thr Ser Asp Ser Phe Val
 1               5                  10                  15      
Lys Gly Tyr Leu Leu Pro Asp
            20              


<210> 2178
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2178
Lys Asn Leu Ser Glu Pro Ser Leu Glu Ala Thr Pro His Cys His Ile
 1               5                  10                  15      
Asn
    


<210> 2179
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2179
Lys Asn Leu Ser Asp Val Asn Ile Leu His Arg Leu
 1               5                  10          


<210> 2180
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2180
Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp Asn Pro Phe Gly
 1               5                  10                  15      
Glu Asp Asn Phe Ser Lys Leu
            20              


<210> 2181
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2181
Lys Asn Ile Ser Asn Asp Thr Phe Gly Thr Thr Tyr Gly Arg Ile His
 1               5                  10                  15      
Met
    


<210> 2182
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2182
Lys Asn His Thr His Gln Gln Asp Ile Asp Asp Leu Lys Arg Gln Asn
 1               5                  10                  15      
Ala Leu Leu Glu Gln Gln Val Arg Ala
            20                  25  


<210> 2183
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2183
Lys Asn Glu Thr Val Ser Ser Asn Ser Ser Asn Asn Thr Gly Asn Ser
 1               5                  10                  15      


<210> 2184
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2184
Lys Asn Glu Ser Ser Pro Ala Pro Pro Asp Ser Asp Ala Asp Lys Leu
 1               5                  10                  15      


<210> 2185
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2185
Lys Asn Glu Ser Asn Leu Gly Asp Leu Leu Leu Gly Phe Leu Lys Tyr
 1               5                  10                  15      


<210> 2186
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2186
Lys Asn Glu Ser Lys Glu Lys Ser Asn Lys Arg
 1               5                  10      


<210> 2187
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2187
Lys Asn Asp Thr Ala Ala Val Gln Leu His Phe Val Ser Gly Asn Asn
 1               5                  10                  15      
Val Leu Ala His Arg Ser Leu
            20              


<210> 2188
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2188
Lys Asn Asp Ser Leu Ile Gln Asn Asp Ser Ile Leu Glu Ser Leu Leu
 1               5                  10                  15      
Glu Val Leu Arg
            20  


<210> 2189
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2189
Lys Asn Asp Ser Asp Leu Phe Gly Leu Gly Leu Glu Glu Ala Gly Pro
 1               5                  10                  15      
Lys Glu
        


<210> 2190
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2190
Lys Asn Asp Ser Asp Cys Gly Val Phe Val Leu Gln Tyr Cys
 1               5                  10                  


<210> 2191
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2191
Lys Asn Ala Thr Leu Val Ser Pro Pro Ala Gln Thr Ile Asn Gln Thr
 1               5                  10                  15      
Pro Val Thr Leu Gln Val Pro Gly Leu
            20                  25  


<210> 2192
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2192
Lys Asn Ala Ser Gly Thr Lys Ala Val Ser Val Met Val Lys Val
 1               5                  10                  15  


<210> 2193
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2193
Lys Met Trp Lys Asn His Ile Ser Ser Arg Asn Thr Thr Pro Leu Pro
 1               5                  10                  15      
Arg Pro Pro Pro Gly Leu Thr Asn Pro
            20                  25  


<210> 2194
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2194
Lys Met Val Ala Trp Ser Ser Ser Glu Asn Met Ser Glu Glu Ser Val
 1               5                  10                  15      
Val Leu Ser Phe Pro Arg Phe
            20              


<210> 2195
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2195
Lys Met Pro Tyr Ile Gln Asn Leu Ser Ser Leu Pro Thr Arg Thr Glu
 1               5                  10                  15      
Leu Arg Thr
            


<210> 2196
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2196
Lys Met Asn Arg Thr Ala Leu His Leu Ala Cys Ala Asn Gly His Pro
 1               5                  10                  15      
Glu Val Val Thr Leu
            20      


<210> 2197
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2197
Lys Met Asn Leu Thr Gln Asn Thr Leu Gly Tyr Glu Gly Ile Val Lys
 1               5                  10                  15      
Leu Tyr Lys Val Leu Lys Ser
            20              


<210> 2198
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2198
Lys Met Met Asn Asp Ser Ile Leu Arg Leu Gln Thr Trp Asp Glu Ala
 1               5                  10                  15      
Val Phe Arg Glu
            20  


<210> 2199
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2199
Lys Met Leu Ser Leu Asn Asn Tyr Ser Val Pro Gln Ser Thr Arg Glu
 1               5                  10                  15      


<210> 2200
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2200
Lys Met Phe Leu Asn Asn Thr Thr Thr Asn Arg His Thr Ser Gly Glu
 1               5                  10                  15      
Gly Pro Gly Ser Lys Thr Gly Asp Lys Glu Glu Lys
            20                  25              


<210> 2201
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2201
Lys Met Phe Ile Leu Ser Asp Gly Glu Gly Lys Asn Gly Thr Ile Glu
 1               5                  10                  15      
Leu Met Glu Pro Leu
            20      


<210> 2202
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2202
Lys Met Phe Phe Glu Thr Asn Glu Asn Asn Asp Thr Thr Tyr Gln Asn
 1               5                  10                  15      
Leu Trp Asp Ala Phe
            20      


<210> 2203
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2203
Lys Met Glu Val Gly Ile Glu Asp Cys Leu His Ile Glu Phe Glu Tyr
 1               5                  10                  15      
Asn Lys Ser Lys Tyr
            20      


<210> 2204
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2204
Lys Met Glu Gln Lys Ala Lys Gln Asn Gln Val Ala Ser Pro Gln Pro
 1               5                  10                  15      
Pro His Pro Gly Glu Ile Thr Asn Ala His Asn Ser Ser Cys Ile Ser
            20                  25                  30          
Asn Lys Phe
        35  


<210> 2205
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2205
Lys Met Glu Asn Gly Gln Gln Ala Ala Asp Asn Ile Leu Ser Ala Val
 1               5                  10                  15      
Pro Pro Gly Leu Ile Asn Thr Ser Glu Ala Gly Ile Pro Ala Met Ser
            20                  25                  30          
Thr Asn Asp Leu
        35      


<210> 2206
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2206
Lys Met Ala Ala Ala Asn Leu Thr Phe Ser Gln Glu Val Val Trp Gln
 1               5                  10                  15      
Arg Gly
        


<210> 2207
<211> 38
<212> PRT
<213> Homo sapiens

<400> 2207
Lys Leu Val Gly Phe Pro Ala Tyr Gly His Ser Phe Leu Leu Ser Asn
 1               5                  10                  15      
Pro Ser Asn His Gly Ile Asp Ala Pro Thr Thr Gly Pro Gly Pro Ala
            20                  25                  30          
Gly Pro Tyr Thr Arg Gln
        35              


<210> 2208
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2208
Lys Leu Ser Thr Leu Leu Asn His Asn Asn Asp Thr Glu Glu Glu Glu
 1               5                  10                  15      
Arg Leu
        


<210> 2209
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2209
Lys Leu Ser Ser Gln Gly Asn Val Ser Gly Lys Arg Lys Asn
 1               5                  10                  


<210> 2210
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2210
Lys Leu Ser Pro Gly Asn Ser Gly Asn Tyr Ser Ser Gly Ala Ser Ser
 1               5                  10                  15      
Ala Ser Ala Ser Gly Ser Ser
            20              


<210> 2211
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2211
Lys Leu Ser Asn Asn Leu Asn Val Glu Gly Gly Ser Ser Glu Asn Asn
 1               5                  10                  15      
His Ser Ile Lys
            20  


<210> 2212
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2212
Lys Leu Arg Pro Val Thr Leu Thr Glu Met Asn Tyr Ser Lys Tyr Gly
 1               5                  10                  15      
Ala Lys Glu
            


<210> 2213
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2213
Lys Leu Arg Lys Glu Gln Leu Lys Glu Glu Leu Asn Glu Asn Gln Ser
 1               5                  10                  15      
Thr Pro Lys Lys Glu Lys Gln
            20              


<210> 2214
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2214
Lys Leu Arg Ile Phe Tyr Gln Phe Leu Tyr Asn Asn Asn Thr Arg Gln
 1               5                  10                  15      


<210> 2215
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2215
Lys Leu Gln Ile Asn Asn Leu Thr Met Asn Leu Ile Glu Leu Glu Asn
 1               5                  10                  15      


<210> 2216
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2216
Lys Leu Gln Glu Ser Ile Glu Tyr Glu Asp Leu Gly Lys Asn Asn Ser
 1               5                  10                  15      
Val Lys Thr
            


<210> 2217
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2217
Lys Leu Pro Leu Ser His Ser Ala Leu Pro Ser Gln Ala Leu Gly Gly
 1               5                  10                  15      
Ile Ala Ser Gly Leu Gly Met Gln Asn Leu Asn Ser Ser Arg
            20                  25                  30  


<210> 2218
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2218
Lys Leu Pro Lys Asn Glu Pro Gln Asn Ala Thr Gly Ala Pro Gly Arg
 1               5                  10                  15      
Asn
    


<210> 2219
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2219
Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu Asp Val Pro Trp
 1               5                  10                  15      
Ile Thr Leu Asn Ser Ser Ile Gln Lys Val
            20                  25      


<210> 2220
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2220
Lys Leu Asn Tyr Leu Pro Pro Asn Ala Ser Ala Leu Phe Arg Lys
 1               5                  10                  15  


<210> 2221
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2221
Lys Leu Asn Leu Asn Val Ala Pro Asp Ser His Gly Thr Leu Ile Pro
 1               5                  10                  15      
Asp Thr Asn Glu Thr Ile Thr Leu Ala Ser His
            20                  25          


<210> 2222
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2222
Lys Leu Met Leu Val Ser Ala Pro Ser Ile Leu Ser Ser Gly Asn Gly
 1               5                  10                  15      
Thr Ala Ile Asn Met Thr
            20          


<210> 2223
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2223
Lys Leu Leu Tyr Asn Leu Arg Ala Ser Leu Asn Lys Asn Gln Ser Ser
 1               5                  10                  15      
Arg His
        


<210> 2224
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2224
Lys Leu Leu Val Asn Leu Ala Asp His Asn Gly Asn Thr Ala Leu His
 1               5                  10                  15      
Tyr Ser Val Ser His Ser Asn Phe Ser Ile Val Lys Leu
            20                  25                  


<210> 2225
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2225
Lys Leu Leu Gln Thr Thr Asn Asn Ser Pro Met Asn Ser Lys Pro Gln
 1               5                  10                  15      


<210> 2226
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2226
Lys Leu Leu Asn Ser Asn Lys Ser Gly Ala Ala Phe Asn Gln Ser Lys
 1               5                  10                  15      
Ser Leu Thr Leu Pro Gln Thr Cys Asn Arg Glu
            20                  25          


<210> 2227
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2227
Lys Leu Leu Leu Lys Ile Lys Asn Gly Thr Pro Pro Met Arg Lys
 1               5                  10                  15  


<210> 2228
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2228
Lys Leu Lys Met Leu Thr Asn Pro Ser Thr Ala Asn Ser Asn Leu Leu
 1               5                  10                  15      
Leu His Gln Ser
            20  


<210> 2229
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2229
Lys Leu Lys Leu Phe Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu
 1               5                  10                  15      
Asp Ile Pro Val Lys Thr Leu Asn Met Lys Thr
            20                  25          


<210> 2230
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2230
Lys Leu Ile Pro Phe Ser Pro Ala Val Asn Thr Ser Val Ser Thr Val
 1               5                  10                  15      
Ala Ser Thr Val Ala Pro Met Tyr Ala Gly Asp Leu Arg Thr
            20                  25                  30  


<210> 2231
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2231
Lys Leu Ile Asn Tyr Asn Asn Ser Ile Thr Asn Ser Val Tyr Ser Arg
 1               5                  10                  15      
Phe
    


<210> 2232
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2232
Lys Leu Ile Leu Ser Gln Asn His Ser Asp Glu Glu Glu Glu Glu Glu
 1               5                  10                  15      
Glu Asn Glu Glu Glu Asn Leu Ala Met Ala Val Gly Met Gly Glu Arg
            20                  25                  30          


<210> 2233
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2233
Lys Leu Ile Lys Thr Asp Glu Ser Val Val Asp Arg Ala Lys Ala Asn
 1               5                  10                  15      
Ala Ser Leu Trp Glu Ala Arg Leu
            20                  


<210> 2234
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2234
Lys Leu His Pro Phe Gly Ser Leu Gln Gln Glu Met Gly Pro Val Asn
 1               5                  10                  15      
Ser Thr Asn Ala Thr Gln Asp Arg Ser
            20                  25  


<210> 2235
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2235
Lys Leu Gly Val Asn Asn Ile Ser Gly Ile Glu Glu Ala Ser Asn Met
 1               5                  10                  15      
Phe Thr Asn
            


<210> 2236
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2236
Lys Leu Phe Lys Glu Val Ala Ser Leu Gln Glu Asn Phe Glu Val Phe
 1               5                  10                  15      
Leu Ser Phe Glu Asp Tyr Ser Asn Ser Ser Leu Val Ala Asp Leu Arg
            20                  25                  30          
Glu
    


<210> 2237
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2237
Lys Leu Glu Val Glu Asp Leu Asp Glu Asn Phe Leu Asn Ser Ser Tyr
 1               5                  10                  15      
Gln Thr Val Phe Lys Thr
            20          


<210> 2238
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2238
Lys Leu Glu Leu Asn Pro His Thr Val Glu Asn Val Thr Lys Asn Glu
 1               5                  10                  15      
Asp Ser Met Thr Gly Ile Glu Val Glu Lys Trp Thr Gln Asn Lys Lys
            20                  25                  30          
Ser
    


<210> 2239
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2239
Lys Leu Glu Phe Leu Pro Glu Glu Ile Gly Gln Met Gln Lys Leu Arg
 1               5                  10                  15      
Val Leu Asn Leu Ser Asp Asn Arg Leu Lys
            20                  25      


<210> 2240
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2240
Lys Leu Glu Glu Tyr Lys Glu Ala Phe Ala Val Ala Leu Lys Ala Asn
 1               5                  10                  15      
Asn Ser Met Ser Lys Lys
            20          


<210> 2241
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2241
Lys Leu Asp Asn Leu Met Leu Glu Leu Asp Gly Thr Glu Asn Lys Ser
 1               5                  10                  15      
Lys Phe
        


<210> 2242
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2242
Lys Leu Asp Lys Leu Leu Lys Leu Arg Glu Leu Asn Leu Ser Tyr Asn
 1               5                  10                  15      
Lys Ile
        


<210> 2243
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2243
Lys Leu Ala Ser Asn Gly Thr Pro Met Gly Thr Phe Ala Pro Leu Trp
 1               5                  10                  15      
Glu Val Phe Arg Val
            20      


<210> 2244
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2244
Lys Leu Ala Leu Arg Asn Asn Ser Ala Ser Thr Thr Gln His Leu Arg
 1               5                  10                  15      
Leu
    


<210> 2245
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2245
Lys Leu Ala Lys Ile Arg Asp Asn Leu Ala Ile Ser Leu Asp Asn Gln
 1               5                  10                  15      
Ser Ser Pro Ser Pro Pro Val Leu Ile
            20                  25  


<210> 2246
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2246
Lys Lys Tyr Leu Trp Glu Asn Glu Thr Val Gly Ala Gln Asp Asp Pro
 1               5                  10                  15      
Leu Ala
        


<210> 2247
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2247
Lys Lys Trp Arg Val Glu Asn Gln Glu Asn Val Ser Asn Leu Val Ile
 1               5                  10                  15      
Glu Asp Thr Glu Leu Lys Gln
            20              


<210> 2248
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2248
Lys Lys Val Thr Cys Pro Pro Thr Val Thr Val Lys Asp Glu Gln Ser
 1               5                  10                  15      
Gly Gly Gly Asn Val Ser Ser Thr Leu Leu Lys Gln
            20                  25              


<210> 2249
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2249
Lys Lys Val Leu Ala Pro Arg Val Asn Leu Thr Phe Arg Lys
 1               5                  10                  


<210> 2250
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2250
Lys Lys Val Ile Phe Ser Glu Glu Ile Thr Asn Leu Ser Gln Met Thr
 1               5                  10                  15      
Leu Asn Val Gln Gly Pro Ser Cys Ile Leu Lys Lys
            20                  25              


<210> 2251
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2251
Lys Lys Ser Asn Gln Leu Glu Asn His Thr Ile Val Gly Thr Arg Ser
 1               5                  10                  15      


<210> 2252
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2252
Lys Lys Ser Phe Ala Cys Ser Ser Cys Asn Tyr Thr Phe Ala Lys Lys
 1               5                  10                  15      
Glu Gln Phe Asp
            20  


<210> 2253
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2253
Lys Lys Arg Gln Glu Glu Asn Ser Gln Asn Ser Ser Glu Lys Val Met
 1               5                  10                  15      
Phe Gln Ser Thr His Ile Leu Pro Asp Glu Glu Lys Met Val Lys Glu
            20                  25                  30          


<210> 2254
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2254
Lys Lys Arg Asn Arg Ser Ser Ser Val Ser Ser Ser Ala Ala Ser Ser
 1               5                  10                  15      
Pro Glu Arg Lys Lys
            20      


<210> 2255
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2255
Lys Lys Gln Pro Phe Ser Ser Ala Ser Ser Gln Asn Gly Ser Leu Ser
 1               5                  10                  15      
Pro His Tyr Leu Ser Ser Val Ile Lys Gln
            20                  25      


<210> 2256
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2256
Lys Lys Pro Tyr Val Ser Leu Ala Gln Gln Met Ala Pro Pro Ser Pro
 1               5                  10                  15      
Ser Asn Ser Thr Pro Asn Ser Ser Ser Gly Ser Asn Gly Asn Asp Gln
            20                  25                  30          
Leu Ser Lys Thr
        35      


<210> 2257
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2257
Lys Lys Pro Lys Gly Ile Asn Ser Asn Ser Thr Ala Asn Leu
 1               5                  10                  


<210> 2258
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2258
Lys Lys Asn Thr Phe Asn Phe Thr Leu Ile Ser Trp His Ser Gly Leu
 1               5                  10                  15      
Lys Asp
        


<210> 2259
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2259
Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr Val Leu Gln Leu Lys
 1               5                  10                  15      
Gln Pro Leu Asn Thr Thr Arg Ile
            20                  


<210> 2260
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2260
Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser Gln Ala Phe Leu Arg
 1               5                  10                  15      
His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg Asp
            20                  25              


<210> 2261
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2261
Lys Lys Met Asn Met Met Asn Arg Ser Tyr Asn Val Thr Leu Lys Arg
 1               5                  10                  15      
Gln
    


<210> 2262
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2262
Lys Lys Met Leu Tyr Arg Asp Phe Asn Met Thr Gly Trp Ala Tyr Lys
 1               5                  10                  15      
Thr
    


<210> 2263
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2263
Lys Lys Leu Ser Asn Phe Ser Phe Leu Thr His Arg Gln
 1               5                  10              


<210> 2264
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2264
Lys Lys Leu Cys Gly Glu Asn Asp Arg Leu Asn His Thr Tyr Ser Gln
 1               5                  10                  15      
Leu Leu Lys
            


<210> 2265
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2265
Lys Lys Leu Ala Glu Ile Leu Val Asn Thr Ser Ser Glu Asn Trp Ile
 1               5                  10                  15      
Arg Asn
        


<210> 2266
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2266
Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp Gly Ser
 1               5                  10                  15      
Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala Leu Gln
            20                  25                  30          
Lys Lys Leu
        35  


<210> 2267
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2267
Lys Lys Lys Pro Ser Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys
 1               5                  10                  15      
Leu Tyr Ala Thr Met Glu Lys His Lys Glu
            20                  25      


<210> 2268
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2268
Lys Lys Lys Lys Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr
 1               5                  10                  15      
Leu Ala Lys
            


<210> 2269
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2269
Lys Lys Lys Asp Ser Leu His Gly Ser Thr Gly Ala Val Asn Ala Thr
 1               5                  10                  15      
Arg Pro Thr Leu
            20  


<210> 2270
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2270
Lys Lys Ile Asn Leu Asn His Leu Leu Asn Phe Thr Phe Glu Pro Arg
 1               5                  10                  15      
Gly
    


<210> 2271
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2271
Lys Lys His His His His Ala Val Gly Leu Asn Leu Ser His Val Arg
 1               5                  10                  15      
Lys Arg Cys
            


<210> 2272
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2272
Lys Lys His Ala Tyr Cys Ser Asn Leu Ser Phe Arg Leu
 1               5                  10              


<210> 2273
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2273
Lys Lys Glu Tyr Asn Val Asn Asp Asp Ser Met Lys Leu Gly Gly Asn
 1               5                  10                  15      
Asn Thr Ser Glu Lys Ala
            20          


<210> 2274
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2274
Lys Lys Glu Trp Asn Asp Ser Thr Ser Val Gln Asn Pro Thr Arg Leu
 1               5                  10                  15      
Arg Glu
        


<210> 2275
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2275
Lys Lys Glu Asp Tyr Asn Glu Thr Ala Pro Met Leu Glu Gln Val
 1               5                  10                  15  


<210> 2276
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2276
Lys Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu
 1               5                  10                  15      
Gly Leu Ser Met Gly Asn Tyr Met Gly Leu Ile Asn Arg Ile Ala Gln
            20                  25                  30          
Lys Lys Arg Leu
        35      


<210> 2277
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2277
Lys Ile Thr Lys Asn Phe Ser Glu Val Gly Phe Pro Asp Ile Leu Lys
 1               5                  10                  15      
Ala
    


<210> 2278
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2278
Lys Ile Ser Asn Val Ala Leu Asp Ser Met His Trp Gln Asn Asp Ser
 1               5                  10                  15      
Val Gln Ile
            


<210> 2279
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2279
Lys Ile Ser Leu Lys Ile Gln Asn Cys Arg Asn Val Thr Ser Leu Pro
 1               5                  10                  15      
Cys Leu Ser Leu Arg Lys
            20          


<210> 2280
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2280
Lys Ile Asn Leu Leu Asn Leu Thr Phe Cys Leu Phe Val Trp Leu Thr
 1               5                  10                  15      
Phe Asn Leu Pro Phe Leu Lys Asn
            20                  


<210> 2281
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2281
Lys Ile Met Cys Leu Asp Glu Lys Ile Asp Asn Phe Thr Arg Gln
 1               5                  10                  15  


<210> 2282
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2282
Lys Ile Leu Gln Pro Asn Thr Thr Asp Glu Phe Val Ile Pro Leu Asp
 1               5                  10                  15      
Pro Arg Trp
            


<210> 2283
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2283
Lys Ile Leu His Asn Val Ser Glu Asp Pro Ser Phe Val Ile Ser Gln
 1               5                  10                  15      
His Ile Arg Lys
            20  


<210> 2284
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2284
Lys Ile Lys Asn Met Asn Ser Thr Leu Thr Phe Val Thr Leu Ser Gly
 1               5                  10                  15      
Glu Leu Arg Ala Arg Arg
            20          


<210> 2285
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2285
Lys Ile Lys Lys His Phe Asn Thr Gly Pro Lys Pro Asn Ser Thr Ala
 1               5                  10                  15      
Ala Gly Val Ser Val Ile Ala Thr Thr Ala Leu Asp Lys Glu
            20                  25                  30  


<210> 2286
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2286
Lys Ile Gly Leu Asn Ile Gly Gln Ala Ile Val Asn Thr Ser Gly Thr
 1               5                  10                  15      
Val Pro Ala Ile Pro Ser Ile Asn Ile Leu Gln Asn Val Thr Pro Lys
            20                  25                  30          
Gly Glu Asp Lys Ser
        35          


<210> 2287
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2287
Lys Ile Gly His Pro His Gly Leu Gln Val Thr Tyr Leu Lys Asp Asn
 1               5                  10                  15      
Ser Thr Arg Asn
            20  


<210> 2288
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2288
Lys Ile Glu Glu Glu Glu Glu Glu Glu Asn Gly Asp Ser Val Val Gln
 1               5                  10                  15      
Asn Asn Asn Thr Ser Gln Met Ser His Lys Lys Val
            20                  25              


<210> 2289
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2289
Lys Ile Asp Arg Leu Asp Gly Thr Pro Gln Glu Pro Leu Cys Gly Phe
 1               5                  10                  15      
Ser Lys Gln Met Val Glu Ile Val His Lys His Asn Ile Ser Leu Ala
            20                  25                  30          
Val Leu Met Ser Leu
        35          


<210> 2290
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2290
Lys His Val Thr Met Asp Gln Val Gly Thr Phe Ala Gly Leu Leu Ile
 1               5                  10                  15      
Gly Leu Ala Gln Leu Asn Cys Ser Glu Leu Lys Leu Lys Arg
            20                  25                  30  


<210> 2291
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2291
Lys His Val Glu Val Asn Gly Ser Lys Thr Ala Gly Ala Asn Thr Thr
 1               5                  10                  15      
Asp Lys Glu
            


<210> 2292
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2292
Lys His Thr Val Ser Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn
 1               5                  10                  15      
Ala Asn Ser Ser Gln Phe Phe Ile Cys Ala Ala Lys Thr
            20                  25                  


<210> 2293
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2293
Lys His Thr Gly Thr Ile Pro Gly Ala Gln Gly Leu Met Asn Ser Ser
 1               5                  10                  15      
Leu Leu His Gln Asp Ile
            20          


<210> 2294
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2294
Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn
 1               5                  10                  15      
Met Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr
            20                  25                  


<210> 2295
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2295
Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn
 1               5                  10                  15      
Ala Asn Gly Ser Gln Phe Phe Met Cys Pro Ala Lys
            20                  25              


<210> 2296
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2296
Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Ile
 1               5                  10                  15      
Thr Asn Ser Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr
            20                  25                  


<210> 2297
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2297
Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Leu Asn
 1               5                  10                  15      
Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr
            20                  25                  


<210> 2298
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2298
Lys His Ser Ser Gly Thr Ser Asn Thr Ser Thr Ala Asn Arg Ser Thr
 1               5                  10                  15      
His Asn Glu Leu Glu Lys Asn
            20              


<210> 2299
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2299
Lys His Ser Ser Gly Ser Ser Asn Thr Ser Thr Ala Asn Arg Arg Ala
 1               5                  10                  15      


<210> 2300
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2300
Lys His Ser Arg Ile Val Glu Leu Leu Asn Glu Thr Glu Lys Tyr Lys
 1               5                  10                  15      
Leu
    


<210> 2301
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2301
Lys His Ser Lys Ala Leu Asn Thr Leu Ser Ser Pro Gly Gln Ser Ser
 1               5                  10                  15      
Phe Ser His Gly Thr Arg Asn Asn Ser Ala Lys Glu
            20                  25              


<210> 2302
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2302
Lys His Asn Ser Ser Ser Ser Ala Leu Leu Asn Ser Pro Thr Val Thr
 1               5                  10                  15      
Thr Ser Ser Cys Ala Gly Ala Ser Glu Lys Lys Lys Phe
            20                  25                  


<210> 2303
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2303
Lys His Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val
 1               5                  10                  15  


<210> 2304
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2304
Lys His Leu Ser Asp Tyr Cys Ile Gly Pro Asn Ala Ser Ile Asn Val
 1               5                  10                  15      
Ile Met Gln Pro Leu Glu Lys Met
            20                  


<210> 2305
<211> 8
<212> PRT
<213> Homo sapiens

<400> 2305
Lys His Leu Lys Asn Asn Ser Ser
 1               5              


<210> 2306
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2306
Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile Asn Ile Thr Leu
 1               5                  10                  15      
Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu Asn Leu Arg Ala
            20                  25                  30          


<210> 2307
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2307
Lys His Lys Gly Leu Ile Glu Ile Pro Ser Leu Ser Glu Glu Asn Glu
 1               5                  10                  15      
Ile Asn Asp Thr Glu Val Asn Val Ser Lys Lys
            20                  25          


<210> 2308
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2308
Lys His Gly Asn Leu Arg Asn Val Leu Ile Leu Met Asp Gln Ser Ala
 1               5                  10                  15      
Trp Asp Ser Asn Ala Thr Leu Arg Gln
            20                  25  


<210> 2309
<211> 38
<212> PRT
<213> Homo sapiens

<400> 2309
Lys His Gly Ile Glu Ala Ala Phe Leu Ala Met Leu Gly Leu Gln Gly
 1               5                  10                  15      
Asn Lys Gln Val Leu Asp Leu Glu Ala Gly Phe Gly Ala Phe Tyr Ala
            20                  25                  30          
Asn Tyr Ser Pro Lys Val
        35              


<210> 2310
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2310
Lys Gly Val Ser Phe Asn Glu Ser Ala Ala Asp Asn Leu Lys Leu
 1               5                  10                  15  


<210> 2311
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2311
Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu Gly Asp Pro Ser Glu Asn
 1               5                  10                  15      
Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu
            20                  25      


<210> 2312
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2312
Lys Gly Thr Lys Asn Phe Ser Leu Leu Ser Phe Gly Glu Glu Ala Glu
 1               5                  10                  15      
Glu Glu Glu Glu Glu Val Asn
            20              


<210> 2313
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2313
Lys Gly Ser Cys Phe His Ser Ile Ile Pro Gly Phe Met Cys Gln Gly
 1               5                  10                  15      
Gly Asp Phe Thr Leu Leu Asn Gly Thr Gly Gly Lys Ser
            20                  25                  


<210> 2314
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2314
Lys Gly Arg Ile Gly Val Val Ile Ser Ser Tyr Met His Phe Thr Asn
 1               5                  10                  15      
Val Ser Ala Ser Ala Asp Gln Ala Leu Asp Arg Phe
            20                  25              


<210> 2315
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2315
Lys Gly Arg Gly Leu Asn Ala Met Ala Asn Glu Thr Pro Asp Phe Met
 1               5                  10                  15      
Arg Ala
        


<210> 2316
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2316
Lys Gly Arg Ala Asn His Ser Ala Phe Leu Phe Gly Phe Gly Asp Gly
 1               5                  10                  15      
Gly Gly Gly Pro Thr Gln Thr Met Leu Asp Arg Leu
            20                  25              


<210> 2317
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2317
Lys Gly Gln Ser Val Ser Ser Pro Pro Asn Asp Cys Asn Ile Ser Pro
 1               5                  10                  15      
Ala Arg Val
            


<210> 2318
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2318
Lys Gly Gln Asn Leu Asn Asn Tyr Ser Phe Ser Thr Asn Gly Phe Ser
 1               5                  10                  15      
Gly Ser Gly Gly Ser Gly Ser His Gly Ser Ser
            20                  25          


<210> 2319
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2319
Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr Leu Glu Asn Gln Lys Gly
 1               5                  10                  15      


<210> 2320
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2320
Lys Gly Asn Cys Glu Asp Tyr Leu Met Ile Ser Cys Asn Asn Ser Asp
 1               5                  10                  15      
Gly Ile Glu Asn Arg Asn
            20          


<210> 2321
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2321
Lys Gly Asn Met Thr Leu Ser Pro Glu Asn Gly Tyr Trp Val Val Ile
 1               5                  10                  15      
Met Met Lys Glu
            20  


<210> 2322
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2322
Lys Gly Leu Ser Asn His Phe Gln Val Asn His Thr Val Ala Leu Ser
 1               5                  10                  15      
Thr Ile Gly Glu Ser Asn Tyr His Phe Gly Val
            20                  25          


<210> 2323
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2323
Lys Gly Leu Arg Gly Pro Gly Ser Ile Gly Ser Glu Pro Asp Phe Trp
 1               5                  10                  15      
Asn Gly Ser Gly Ser Ser Arg Val Lys Gly
            20                  25      


<210> 2324
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2324
Lys Gly Leu Phe Lys Gly Gly Asp Met Ser Lys Asn Val Ser Gln Ser
 1               5                  10                  15      
Gln Met Ala Lys Leu
            20      


<210> 2325
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2325
Lys Gly Leu Ala Gln Pro Pro Gln Ala Tyr Phe Asn Gly Ser Leu Pro
 1               5                  10                  15      
Pro Gln Thr Val Gly His Gln Ala His Gly Arg Glu
            20                  25              


<210> 2326
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2326
Lys Gly Lys Asn Phe Asn Asp Asn His Ser Phe Leu Thr Asn Asp Glu
 1               5                  10                  15      
Leu Ala Val Leu Pro Val
            20          


<210> 2327
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2327
Lys Gly Lys Asn Leu Ser Leu Ser Leu Asp Ala Leu Phe Met Gly Lys
 1               5                  10                  15      
Ser
    


<210> 2328
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2328
Lys Gly Ile Val Val Leu Ile Asp Pro Leu Ala Ala Asn Gly Thr Thr
 1               5                  10                  15      
Asp Met His Thr Ser Val Pro Arg Val
            20                  25  


<210> 2329
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2329
Lys Gly Ile Asp Ile Ile Ile Glu Met Leu Ala Asn Val Asn Leu Ser
 1               5                  10                  15      
Lys Asp Leu Ser
            20  


<210> 2330
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2330
Lys Gly Phe Ser Gln Leu Ser Asn Leu Thr Lys His
 1               5                  10          


<210> 2331
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2331
Lys Gly Glu Thr Trp Ala Thr Pro Asn Cys Ser Glu Ala Thr Cys Glu
 1               5                  10                  15      
Gly Asn Asn Val Ile Ser Leu Ser Pro
            20                  25  


<210> 2332
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2332
Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala
 1               5                  10                  15      
Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys
            20                  25          


<210> 2333
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2333
Lys Gly Glu Glu Arg Ser Ser Cys Ile Ser Gly Asn Asn Phe Ser Trp
 1               5                  10                  15      
Ser Leu Gln Trp Asn Gly Lys Glu
            20                  


<210> 2334
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2334
Lys Gly Asp Phe Glu Ser Gln Asn Ser Ser Leu Glu Ser Ser Ile Ser
 1               5                  10                  15      
Gln Val Ile Asn Leu Glu Lys Asn
            20                  


<210> 2335
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2335
Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala Pro Asn
 1               5                  10                  15      
Asn Ser Cys Ser Glu Ile Lys Met Asn Lys Lys
            20                  25          


<210> 2336
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2336
Lys Gly Ala Met Gln Thr Gly Leu Asn Thr Thr Gln Asn Ile Ala Thr
 1               5                  10                  15      
Gly Thr Lys Asp
            20  


<210> 2337
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2337
Lys Gly Ala Glu Ile Glu Val Asp Glu Asn Gly Thr Leu Asp Leu Ser
 1               5                  10                  15      
Met Lys Lys Asn
            20  


<210> 2338
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2338
Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp Leu Val Gly Asn Asn Thr
 1               5                  10                  15      
Pro Ile Phe Phe Ile Arg Asp
            20              


<210> 2339
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2339
Lys Phe Ser Pro Ser Asp Thr Asp Glu Asn Ala Thr Asn Thr Gln Ser
 1               5                  10                  15      
Thr Thr
        


<210> 2340
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2340
Lys Phe Arg Met Val Tyr Asn Leu Thr Tyr Asn Thr Met Ala Thr His
 1               5                  10                  15      
Glu Asp Val Asp Thr Thr Met Leu Arg Arg
            20                  25      


<210> 2341
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2341
Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro
 1               5                  10                  15      
Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro
            20                  25                  


<210> 2342
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2342
Lys Phe Asn Gly Gly Gly His Ile Asn His Ser Ile Phe Trp Thr Asn
 1               5                  10                  15      
Leu Ser Pro Asn Gly
            20      


<210> 2343
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2343
Lys Phe Asn Leu Thr Glu Asp Met Tyr Ala Gln Asp Ser Ile Glu Leu
 1               5                  10                  15      
Leu Thr Thr Ser Gly Ile Gln Phe Lys Lys His
            20                  25          


<210> 2344
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2344
Lys Phe Asn Lys Ser Leu Gly His Gly Leu Ile Asn Lys Lys Arg
 1               5                  10                  15  


<210> 2345
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2345
Lys Phe Leu Val His Asp Ile Asn Glu Leu Glu Val Leu Met Met Cys
 1               5                  10                  15      
Asn Lys Ser Tyr Cys Ala Lys Ile Ala His Asn Val Ser Ser Lys Asn
            20                  25                  30          


<210> 2346
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2346
Lys Phe Ile Lys Asn Gln His Cys Thr Asn Ile Ser Glu Leu Ser Asn
 1               5                  10                  15      
Thr Ser Glu Asn Asp
            20      


<210> 2347
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2347
Lys Phe His His Leu Ile Pro Ala His Thr Phe Thr Asn Ile Ser Thr
 1               5                  10                  15      
Lys Asn Pro Gln Gly Ser Lys Ser
            20                  


<210> 2348
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2348
Lys Phe Glu Glu Asn Thr Ser Asn Ser Gln Trp His Val Ser Leu Ser
 1               5                  10                  15      
Val Ser Phe Lys Lys
            20      


<210> 2349
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2349
Lys Phe Glu Ala Leu Lys Glu Glu Asn Met Asp Leu Asn Asn Met Asn
 1               5                  10                  15      
Gln Ser Leu Thr Leu Glu
            20          


<210> 2350
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2350
Lys Phe Cys Asp Asn Ser Ser Ala Ile Gln Gly Lys Glu Val Arg Phe
 1               5                  10                  15      
Leu Arg Pro
            


<210> 2351
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2351
Lys Glu Tyr Pro Asn Leu Ser Thr Ser Leu Asp Asp Ala Phe Leu Leu
 1               5                  10                  15      
Arg Phe
        


<210> 2352
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2352
Lys Glu Val Thr Gln Ala Thr Gln Pro Glu Ala Ile Pro Gln Gly Thr
 1               5                  10                  15      
Asn Ile Thr Glu Glu Lys Pro Gly Arg Lys
            20                  25      


<210> 2353
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2353
Lys Glu Val Asn Ser Cys Thr Thr Gly Ser Ser Asn Ser Thr Ile Ile
 1               5                  10                  15      
Gly Ser Gln Gly Ser Glu Thr Pro Lys Glu
            20                  25      


<210> 2354
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2354
Lys Glu Val Asp Ile Glu Gly Thr Thr Val Ile Glu Val Gly Leu Asp
 1               5                  10                  15      
Pro Ser Asn Asn Met Thr Leu Ala Val Asp Cys Val Gly Ile Leu Lys
            20                  25                  30          
Leu Arg Asn
        35  


<210> 2355
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2355
Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser Pro Ala Pro Arg Leu Arg
 1               5                  10                  15      
Arg
    


<210> 2356
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2356
Lys Glu Arg Val Glu Asn Tyr Ser Asn Val Ser Ile His Leu Lys Asn
 1               5                  10                  15      
Pro Glu
        


<210> 2357
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2357
Lys Glu Arg Ile Ile Asn Tyr Ala Asn Ser Ser Asp Pro Thr Ser Gly
 1               5                  10                  15      
Val Ser Lys Arg Lys Ser
            20          


<210> 2358
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2358
Lys Glu Gln Asp Tyr Leu Cys His Val Tyr Val Arg Asn Asp Ser Leu
 1               5                  10                  15      
Ala Gly Val Val Ile Ala Asp Asn Glu Tyr Pro Ser Arg
            20                  25                  


<210> 2359
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2359
Lys Glu Pro Val Gly Cys Val Asn Asn Ile Ser Phe Leu Ala Ser Leu
 1               5                  10                  15      
Ala Gly Ser Thr Ser Arg Asn
            20              


<210> 2360
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2360
Lys Glu Asn Asn Leu Thr Glu Asp Asn Pro Asn Leu Ser Met Ala Gln
 1               5                  10                  15      
Arg Arg His
            


<210> 2361
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2361
Lys Glu Asn Met Asn Leu Ser Glu Ala Gln Val Gln Ala Leu Ala Leu
 1               5                  10                  15      
Ser Arg Gln
            


<210> 2362
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2362
Lys Glu Asn Ile Pro Gly Asp Phe Leu Cys Ile Ser Leu Val Asn Ser
 1               5                  10                  15      
Ser Val Gln Leu Arg Tyr Asn Leu Gly Asp Arg Thr
            20                  25              


<210> 2363
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2363
Lys Glu Asn Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys
 1               5                  10                  15      
Lys
    


<210> 2364
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2364
Lys Glu Asn Gln Ser Ile Arg Ala Phe Asn Ser Glu His Lys Ile
 1               5                  10                  15  


<210> 2365
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2365
Lys Glu Asn Asn Thr Gly Tyr Ile Asn Ala Ser His Ile Lys Val
 1               5                  10                  15  


<210> 2366
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2366
Lys Glu Met Asn Lys Ser Asp Leu Asn Thr Asn Asn Leu Leu Phe Lys
 1               5                  10                  15      
Pro Pro Val Glu Ser His Ile Gln Lys Asn Lys Lys
            20                  25              


<210> 2367
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2367
Lys Glu Leu Val Gln Val Gln Thr Leu Met Asp Asn Met Thr Leu Glu
 1               5                  10                  15      
Arg Glu
        


<210> 2368
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2368
Lys Glu Leu Val Asn Ala Gly Cys Asn Leu Ser Thr Leu Asn Ile Thr
 1               5                  10                  15      
Leu Leu Ser Trp Ser Lys Lys Arg
            20                  


<210> 2369
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2369
Lys Glu Leu Gln Gly Pro Gly Tyr Thr Ser Asn Ser Ser Leu Lys Pro
 1               5                  10                  15      


<210> 2370
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2370
Lys Glu Leu Leu Leu Thr Leu Asp Asp Ser Phe Asn Asp Val Gly Ser
 1               5                  10                  15      
Asp Asn Ser Asn Gln Ser Ser Pro Arg Leu Arg Leu Pro Ser Pro Ser
            20                  25                  30          
Met Asp Lys Ile
        35      


<210> 2371
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2371
Lys Glu Leu Phe Gly Asp Asp Ser Glu Asp Glu Gly Ala Ser His His
 1               5                  10                  15      
Ser Gly Ser Asp Asn His Ser Glu Arg Ser
            20                  25      


<210> 2372
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2372
Lys Glu Lys Ile Pro Ser Pro Glu Thr Leu Gln Pro Asp Thr His Asn
 1               5                  10                  15      
Ile Ser Lys Ser
            20  


<210> 2373
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2373
Lys Glu Ile Tyr His Gln Asn Val Gln Asn Leu Thr His Leu Gln Val
 1               5                  10                  15      
Val Glu Val Leu Lys Gln
            20          


<210> 2374
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2374
Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His Glu Val Tyr Glu
 1               5                  10                  15      
Asn Lys Thr
            


<210> 2375
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2375
Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr Val Phe Phe Ser Asn
 1               5                  10                  15      
Lys Thr Leu Ile Thr Glu Arg Glu
            20                  


<210> 2376
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2376
Lys Glu Ile Lys Gly Ile Gln Ile Gly Arg Glu Glu Val Asn Leu Ser
 1               5                  10                  15      
Leu Leu Ala Asp Asp Met Ile Leu Tyr Leu Glu Asn Pro Val Val Ser
            20                  25                  30          
Ala Gln Arg Pro
        35      


<210> 2377
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2377
Lys Glu His Ser Glu Met Ser Asn Asn Val Ser Asp Pro Lys Gly Pro
 1               5                  10                  15      
Pro Ala Lys Ile Ala Arg Leu
            20              


<210> 2378
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2378
Lys Glu His Lys Ala Glu Lys Val Pro Ala Val Ala Asn Tyr Ile Met
 1               5                  10                  15      
Lys Ile His Asn Phe Thr Ser Lys Cys
            20                  25  


<210> 2379
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2379
Lys Glu Gly Lys Glu Asn Thr Arg Ile Thr Asn Leu Thr Val Asn Thr
 1               5                  10                  15      
Gly Leu Asp Cys Ser Glu Lys Thr
            20                  


<210> 2380
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2380
Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly Gln Leu
 1               5                  10                  15      
Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val
            20                  25                  30  


<210> 2381
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2381
Lys Glu Phe Tyr Leu Thr Pro Asn Ser Pro Ala Glu Met Leu His Asn
 1               5                  10                  15      
Val Thr Leu Ala Leu Glu Leu Leu Lys Asp
            20                  25      


<210> 2382
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2382
Lys Glu Glu Gln His Ala Asn Thr Ser Ala Asn Tyr Asp Val Glu Leu
 1               5                  10                  15      
Leu His His Lys Asp
            20      


<210> 2383
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2383
Lys Glu Glu Glu Asn Lys Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn
 1               5                  10                  15      
Asp Thr Arg Asn
            20  


<210> 2384
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2384
Lys Glu Glu Glu Glu Leu Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn
 1               5                  10                  15      
Ile Ser Ala Lys Arg Asn
            20          


<210> 2385
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2385
Lys Glu Glu Asp Phe Met Gln Leu Ser Pro Gln Glu Leu Ile Ser Val
 1               5                  10                  15      
Ile Ser Asn Asp Ser Leu Asn Val Glu Lys Glu
            20                  25          


<210> 2386
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2386
Lys Glu Glu Cys Arg Leu Leu Asn Ala Pro Pro Val Pro Pro Arg Gly
 1               5                  10                  15      
Gly Asn Gly Ser Gly Arg Leu
            20              


<210> 2387
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2387
Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu Leu His Trp Met Pro Glu
 1               5                  10                  15      
Asp Ile Leu Pro Asp Val Trp Val Asn Glu Ser Glu Arg His
            20                  25                  30  


<210> 2388
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2388
Lys Glu Asp Gly Lys Thr Leu Tyr Ala Asn Thr Ile Asn Gly Ser Gly
 1               5                  10                  15      
Leu Ala Ile Asp Arg
            20      


<210> 2389
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2389
Lys Glu Cys Cys Asn Ala Phe Asn Gln Ser Ser Ala Leu Thr Asn His
 1               5                  10                  15      
Lys Arg
        


<210> 2390
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2390
Lys Glu Ala Thr Asn Thr Thr Ser Glu Pro Ser Ala Pro Ser Gln Asp
 1               5                  10                  15      
Leu Leu Asp Leu Ser Pro Ser Pro Arg Met
            20                  25      


<210> 2391
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2391
Lys Glu Ala Asn Ile Asn Ser Thr Ser Ile Ser Asp Asp Asn Ser Ala
 1               5                  10                  15      
Ser Leu Arg Cys
            20  


<210> 2392
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2392
Lys Glu Ala Asn Pro Thr Pro Leu Thr Pro Gly Ala Ser Ser Leu Ser
 1               5                  10                  15      
Gln Leu Gly Ala Tyr Leu Asp Ser Asp Asp Ser Asn Gly Ser Asn
            20                  25                  30      


<210> 2393
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2393
Lys Glu Ala Leu Arg Ala Gly Leu Asn Cys Ser Thr Glu Asn Met Pro
 1               5                  10                  15      
Ile Lys Ile
            


<210> 2394
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2394
Lys Glu Ala Leu Gly Ser Val Val Ala His Ser Thr Phe Ser Ala Met
 1               5                  10                  15      
Lys Ala Asn Thr Met Ser Asn Tyr Thr Leu Leu Pro Pro Ser Leu Leu
            20                  25                  30          
Asp His Arg Arg
        35      


<210> 2395
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2395
Lys Glu Ala Phe Ala Ala Ala Leu Asn Ala Asn Asn Ser Met Ser Lys
 1               5                  10                  15      
Lys
    


<210> 2396
<211> 42
<212> PRT
<213> Homo sapiens

<400> 2396
Lys Glu Ala Ala Ser Gln Arg Pro Leu Ser Ser Ser Ala Ser Asn Arg
 1               5                  10                  15      
Leu Ser Val Ser Ser Leu Leu Ala Ala Gly Ala Pro Met Ser Ser Ser
            20                  25                  30          
Ala Ser Val Pro Asn Leu Ser Ser Arg Glu
        35                  40          


<210> 2397
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2397
Lys Asp Val Thr Ala Leu Glu Asn Ala Thr Val Ala Phe Glu Val Ser
 1               5                  10                  15      
Val Ser His Asp Thr Val Pro Val Lys Trp
            20                  25      


<210> 2398
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2398
Lys Asp Val Ile Ser Asn Thr Ser Asp Val Ile Gly Thr Cys Glu Ala
 1               5                  10                  15      
Ala Asp Val Ala Gln Lys Val Asp Glu Asp Ser Ala Glu Asp Thr Gln
            20                  25                  30          
Ser Asn Asp Gly
        35      


<210> 2399
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2399
Lys Asp Thr Asn Val Gln Val Leu Met Val Leu Gly Ala Gly Arg Gly
 1               5                  10                  15      
Pro Leu Val Asn Ala Ser Leu Arg Ala
            20                  25  


<210> 2400
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2400
Lys Asp Ser Asn Ala Ser Gly Thr Thr Leu
 1               5                  10  


<210> 2401
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2401
Lys Asp Ser Glu Ser Met Ser Phe Ser Asp Leu Glu Asn Trp Ala Val
 1               5                  10                  15      
Ala Asn Ser Ser Glu Pro Gln Leu Glu Asp Ala Lys Arg Glu
            20                  25                  30  


<210> 2402
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2402
Lys Asp Arg Gly Val Thr Arg Phe Gln Glu Asn Ala Ser Glu Gly Lys
 1               5                  10                  15      
Ala Pro Ala Glu Asp Val Phe Lys Lys Pro
            20                  25      


<210> 2403
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2403
Lys Asp Pro Arg Asn Leu Leu Ala Asn Gln Thr Leu Val Tyr Ser Gln
 1               5                  10                  15      
Asp Leu Gly Glu Met Thr Lys Leu
            20                  


<210> 2404
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2404
Lys Asp Pro Pro Ser Glu Ala Asn Ser Ile Gln Ser Ala Asn Ala Thr
 1               5                  10                  15      
Thr Lys Thr Ser Glu Thr Asn His Thr Ser Arg Pro
            20                  25              


<210> 2405
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2405
Lys Asp Pro Lys Glu Lys Gln Ile Glu Pro Ala Met Thr Ser Gln Asn
 1               5                  10                  15      
Ser Lys Arg Asn Thr Ser
            20          


<210> 2406
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2406
Lys Asp Asn Lys Tyr Thr Leu Asn Gln Thr Ser Ala Val Phe Asp Ser
 1               5                  10                  15      
Ile Pro Glu Val Val His Tyr Tyr Ser Asn Glu Lys Leu
            20                  25                  


<210> 2407
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2407
Lys Asp Asn Ser Ser Leu Asn Pro Leu Asp Arg Leu Ile Ser Glu Asp
 1               5                  10                  15      
Lys Lys Glu Lys Met
            20      


<210> 2408
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2408
Lys Asp Asn Lys Ser Pro Leu His Leu Val Gln Met Pro Pro Val Ile
 1               5                  10                  15      
Val Glu Thr Ala
            20  


<210> 2409
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2409
Lys Asp Met Asn Leu Thr Leu Glu Pro Glu Ile Met Pro Ala Ala Thr
 1               5                  10                  15      
Asp Asn Arg Tyr Ile Arg Ala
            20              


<210> 2410
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2410
Lys Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg Cys Leu Lys Leu
 1               5                  10                  15      


<210> 2411
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2411
Lys Asp Ile Ser Ser Ser Glu Met Thr Asn Pro Ser Asp Thr Leu Asn
 1               5                  10                  15      
Ile Glu Thr Leu Leu Asn Gly Ser Val Lys Arg Val Ser Glu Asn Asn
            20                  25                  30          
Gly Asn Gly Lys Asn
        35          


<210> 2412
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2412
Lys Asp Ile Lys Lys Lys Asn Ile Asn Leu Gln Pro Met Trp Gln Leu
 1               5                  10                  15      
Leu Pro Val Glu Gln Asp Thr Ser Asn Val Thr Glu Met Lys Val
            20                  25                  30      


<210> 2413
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2413
Lys Asp His Pro Val Ser Cys Cys Leu Gly Leu Leu Leu Glu Ser Leu
 1               5                  10                  15      
Val Pro Phe Ile Val Asn Asp Asn Ile Thr Asn Asn Phe Phe Arg Phe
            20                  25                  30          


<210> 2414
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2414
Lys Asp Gly Asn Ala Ser Gly Thr Met Leu Leu Glu Ala Leu Asp Cys
 1               5                  10                  15      
Ile Leu Pro Pro Thr Arg Pro
            20              


<210> 2415
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2415
Lys Asp Phe Leu Asn Val Thr Thr Glu Ala Asn Ile Leu Pro
 1               5                  10                  


<210> 2416
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2416
Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp Ile Thr Val Glu Ile
 1               5                  10                  15      
Arg Glu
        


<210> 2417
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2417
Lys Asp Glu His Ala Gln Ser Asn Glu Ile Val Val Asn Asp Ser Gly
 1               5                  10                  15      
Ser Asp Asn Val Lys Lys
            20          


<210> 2418
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2418
Lys Asp Ala Ala His Met Leu Gln Ala Asn Lys Thr
 1               5                  10          


<210> 2419
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2419
Lys Cys Val Ala Glu Asn Asn Ser Gly Ala Val Glu Ser Val Ser Asp
 1               5                  10                  15      
Leu Thr Val Glu Pro Val Thr Tyr Arg Glu
            20                  25      


<210> 2420
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2420
Lys Cys Ser Val Ala Leu Leu Asn Glu Thr Glu Ser Val Leu Ser Tyr
 1               5                  10                  15      
Leu Asp Lys Glu Asp
            20      


<210> 2421
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2421
Lys Cys Ser Glu Asn Ala Thr Met Thr Leu Pro Gly Ile His Pro Pro
 1               5                  10                  15      
Thr Leu Asn Gln Ile Met Asp Trp Ile Cys Leu Leu Leu Asp Ala Asn
            20                  25                  30          
Phe Thr Val Val
        35      


<210> 2422
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2422
Lys Cys Arg Leu Asp Val Asn Thr Glu Leu Asn Ser Ser Ile Glu Asp
 1               5                  10                  15      
Leu Leu Glu Ala Ser Met Pro Ser Ser Asp Thr
            20                  25          


<210> 2423
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2423
Lys Cys Pro Tyr Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg
 1               5                  10                  15      
Cys Gln Asn Val Ser Ala Leu Pro Lys Gly
            20                  25      


<210> 2424
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2424
Lys Cys Pro Glu Cys Asp Gln Asn Phe Ser Asp His Ser Tyr Leu Val
 1               5                  10                  15      
Leu His Gln Lys Ile
            20      


<210> 2425
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2425
Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His Lys Cys
 1               5                  10                  15      
Ile Glu Asn Val Ser Arg Gln
            20              


<210> 2426
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2426
Lys Cys Leu Lys Asn Glu Tyr Val Glu Asn Arg Thr Lys Ser
 1               5                  10                  


<210> 2427
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2427
Lys Cys Gly Ser Ala Tyr Glu Pro Glu Asn Gln Ser Lys Asp
 1               5                  10                  


<210> 2428
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2428
Lys Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu Ser Pro
 1               5                  10                  15      
Gly Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro
            20                  25                  30  


<210> 2429
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2429
Lys Cys Glu Gln Ser Tyr Gly Thr Asn Ser Ser Asp Glu Ser Gly Ser
 1               5                  10                  15      
Phe Ser Glu Ala Asp Ser Glu Ser Cys Pro Val Gln Asp Arg Gly
            20                  25                  30      


<210> 2430
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2430
Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu Leu Asn Val
 1               5                  10                  15      
Ser Arg Arg Thr
            20  


<210> 2431
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2431
Lys Ala Tyr Thr Asp Phe Gln Asn Asn His Ser Ser Pro Lys Pro
 1               5                  10                  15  


<210> 2432
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2432
Lys Ala Tyr Ile His Ala Gln Ala Glu Asn Cys Ser His Thr Ala Glu
 1               5                  10                  15      
Leu Val Ser Trp Lys Arg
            20          


<210> 2433
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2433
Lys Ala Tyr Ala Gly Arg Lys Gln His Tyr Ile Ala Gly Asn Cys Ser
 1               5                  10                  15      
Ser Asn Gly Arg Gly
            20      


<210> 2434
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2434
Lys Ala Val Gln Glu Asp Glu Val Gly Val Pro Gly Ser Asn Ser Ala
 1               5                  10                  15      
Asp Leu Leu Arg Trp Thr Thr Ala Thr Thr Met Lys Val Leu Ser Asn
            20                  25                  30          
Thr Thr Thr Thr Thr
        35          


<210> 2435
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2435
Lys Ala Thr Met Gly Leu Leu Gln Asn Lys Glu Asn Asn Asn Thr Lys
 1               5                  10                  15      
Asp Ser Pro Ser Arg Gln
            20          


<210> 2436
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2436
Lys Ala Thr Glu Asn Gly Leu Val Asn Gly Glu Asn Ser Ile Pro Asn
 1               5                  10                  15      
Gly Thr Arg Ser
            20  


<210> 2437
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2437
Lys Ala Ser Pro Ser Glu Asn Asn Ala Gly Gly Gly Ser Pro Ser Ser
 1               5                  10                  15      
Gly Ser Gly Gly Asn Pro Thr Asn Thr Ser Gly
            20                  25          


<210> 2438
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2438
Lys Ala Ser Ala Ser Pro Gly Glu Asn Asp Ser Gly Thr Gly Gly Glu
 1               5                  10                  15      
Glu Pro Gln Arg Asp Lys Arg
            20              


<210> 2439
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2439
Lys Ala Arg Val Glu Thr Gln Asn His Trp Phe Thr Tyr Asn Glu Thr
 1               5                  10                  15      
Met Thr Val Glu Ser Val Thr Gln Ala Val Ser Asn Leu Ala Leu Gln
            20                  25                  30          
Phe Gly
        


<210> 2440
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2440
Lys Ala Arg Pro Asn Phe Ser Asn Gln Ala Asp His Pro Val Leu Ala
 1               5                  10                  15      
Gly Thr Gly Phe Trp Pro Ala Leu Pro Val Arg Gly
            20                  25              


<210> 2441
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2441
Lys Ala Arg Lys Ser Ile Ala Gln Ser Gly Val Asn Met Cys Asn Gln
 1               5                  10                  15      
Asn Ser Ser Pro His Lys Asn
            20              


<210> 2442
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2442
Lys Ala Gln Leu Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr
 1               5                  10                  15      
Arg Asp Glu Leu Gly Trp Lys Leu
            20                  


<210> 2443
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2443
Lys Ala Gln Gly Asn Ile Thr Ala Glu Val Met Met Gly Ile Leu Arg
 1               5                  10                  15      
Asp
    


<210> 2444
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2444
Lys Ala Gln Ala Glu Ala Asn Ala Thr Ala Ile Ser Asn Leu Leu Pro
 1               5                  10                  15      
Phe Met Glu Tyr Glu Val His Thr Gln Leu Met Asn Lys Leu
            20                  25                  30  


<210> 2445
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2445
Lys Ala Pro Leu Ser Thr Val Ser Ala Asn Thr Thr Asn Met Asp Glu
 1               5                  10                  15      
Val Pro Arg Pro Gln
            20      


<210> 2446
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2446
Lys Ala Pro Leu Asn Glu Thr Gly Glu Val Val Asn Glu Lys Ala Lys
 1               5                  10                  15      
Thr
    


<210> 2447
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2447
Lys Ala Asn Gln Glu Asn Gln Ala Leu Ser Lys Lys Leu Asn Asp Thr
 1               5                  10                  15      
His Asn Glu Leu Asn Asp Ile Lys Gln Lys Val
            20                  25          


<210> 2448
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2448
Lys Ala Asn Met Asp Asn Gly Asn Ala Thr Asp Ile Asn Asp Asn Arg
 1               5                  10                  15      
Ser
    


<210> 2449
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2449
Lys Ala Asn Gly Leu Leu Asp Phe Asp Ile Phe Tyr Asn Val Thr Gly
 1               5                  10                  15      
Cys Leu Arg Asn Met Ser Ser Ala Gly Ala Asp Gly Arg Lys Ala
            20                  25                  30      


<210> 2450
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2450
Lys Ala Asn Leu Thr Asp Met Glu Ser Gly Ser Ser Asn Ala Met Asn
 1               5                  10                  15      
Met Asn Val Gln His Glu Arg Glu
            20                  


<210> 2451
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2451
Lys Ala Asn Ala Thr Gly Gly Gly Gly His Val Gln Met Val Gln Arg
 1               5                  10                  15      
Ala
    


<210> 2452
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2452
Lys Ala Asn Ala Ser Glu Lys Leu Gly Val Leu Thr Ser Arg Glu
 1               5                  10                  15  


<210> 2453
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2453
Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala
 1               5                  10                  15      
Thr Gln Asp
            


<210> 2454
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2454
Lys Ala Met Glu Glu Phe Phe Ser Asp Ser Gly Glu Leu Val Gln Ile
 1               5                  10                  15      
Met Met Ala Thr Ala Asn Glu Asn Leu Ser Ala Lys
            20                  25              


<210> 2455
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2455
Lys Ala Leu Thr Asn Gly Ser Phe Ser Pro Ser Gly Asn Asn Gly Ser
 1               5                  10                  15      
Val Asn Trp Arg Thr
            20      


<210> 2456
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2456
Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp Ser
 1               5                  10                  15      
Ser Gly Pro Glu His Ile Leu Ser Ile Ser Ala Gly Ile Asp Thr Ile
            20                  25                  30          
Gly Glu Ile Leu Lys
        35          


<210> 2457
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2457
Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp Thr Ala Val
 1               5                  10                  15      
Leu Val Ile Asp Asn Gly Ser Gly Met Cys
            20                  25      


<210> 2458
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2458
Lys Ala Leu Phe Leu Glu His Glu Gly Tyr Phe Gly Ala Val Gly Ala
 1               5                  10                  15      
Leu Leu Gly Leu Pro Asn Phe Ser
            20                  


<210> 2459
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2459
Lys Ala Leu Asp Pro Ser Gln Pro Val Thr Phe Val Thr Asn Ser Thr
 1               5                  10                  15      
Tyr Ala Ala Asp Lys Gly Val Asn Lys Glu
            20                  25      


<210> 2460
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2460
Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn Ile Asn Leu Thr Glu Leu
 1               5                  10                  15      
Thr Leu Ala Leu Glu Tyr Glu Leu Leu Val Thr Lys Asn
            20                  25                  


<210> 2461
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2461
Lys Ala Leu Ala Thr Ser Met Leu Thr Gly Glu Ala Gly Ser Leu Pro
 1               5                  10                  15      
Ser Thr His Met Val Val Ala Gly Met Ala Asn Ser Thr Pro Gln Gln
            20                  25                  30          


<210> 2462
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2462
Lys Ala Lys Glu Val Ser Glu Asn Ser Ala Gly His Asn Ser Ser Trp
 1               5                  10                  15      
Phe Ser Arg Arg
            20  


<210> 2463
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2463
Lys Ala Lys Ala Val Ala Leu Asp Ser Asp Asn Ile Ser Leu Lys Ser
 1               5                  10                  15      


<210> 2464
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2464
Lys Ala Lys Ala Gly Phe Ser Glu Trp Leu Ala Val Asp Gly Leu Gly
 1               5                  10                  15      
Ser Pro Ser Asn Asn Ser Lys Glu Asp
            20                  25  


<210> 2465
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2465
Lys Ala Ile Asn Asn Ser Phe Ala Pro Glu Lys Leu Gln Glu Leu Ala
 1               5                  10                  15      
Phe Gln Thr Ile Gln Glu Ile Arg His
            20                  25  


<210> 2466
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2466
Lys Ala Ile Ile Asn Ser Thr Val Thr Pro Asn Met
 1               5                  10          


<210> 2467
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2467
Lys Ala Ile Glu Ser Gly Thr Glu Trp Asn Leu Ser Leu Leu Lys Leu
 1               5                  10                  15      


<210> 2468
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2468
Lys Ala Ile Glu Leu Leu Met Glu Thr Ala Glu Val Glu Gln Asn Gly
 1               5                  10                  15      
Gly Leu Phe Ile Met Asn Gly Ser Arg Arg
            20                  25      


<210> 2469
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2469
Lys Ala Gly Val Val Asn Gly Thr Gly Ala Pro Gly
 1               5                  10          


<210> 2470
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2470
Lys Ala Gly Met Asn Ile Ala Arg Leu Asn Phe Ser His Gly Ser His
 1               5                  10                  15      
Glu Tyr His Ala Glu Ser Ile Ala Asn Val Arg Glu Ala Val Glu Ser
            20                  25                  30          
Phe Ala
        


<210> 2471
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2471
Lys Ala Gly Lys Pro Val Val Ala Ala Pro Gly Ala Gly Asn Leu Thr
 1               5                  10                  15      
Lys Phe Glu Pro Arg Ala
            20          


<210> 2472
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2472
Lys Ala Gly His Gln Val Met Val Phe Val His Ala Arg Asn Ala Thr
 1               5                  10                  15      
Val Arg Thr Ala Met Ser Leu Ile Glu Arg Ala
            20                  25          


<210> 2473
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2473
Lys Ala Gly Gly Val Gly Leu Asn Leu Ser Ala Ala Ser Arg Val Phe
 1               5                  10                  15      
Leu Met Asp Pro Ala Trp Asn Pro Ala Ala Glu Asp Gln Cys
            20                  25                  30  


<210> 2474
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2474
Lys Ala Phe Ser Asn Ser Ser Thr Leu Ala Asn His Lys Ile Thr His
 1               5                  10                  15      
Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu
            20                  25      


<210> 2475
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2475
Lys Ala Glu Asn Ser Ala Ala Val Gln Ile Asn Leu Ser Pro Thr Met
 1               5                  10                  15      
Leu Glu Asn Val Lys Lys
            20          


<210> 2476
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2476
Lys Ala Glu Asn Asp Glu Asn Gly Gln Ala Glu Asn Phe Ser Met Asp
 1               5                  10                  15      
Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg Asn
            20                  25              


<210> 2477
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2477
Lys Ala Glu Asp Cys Glu Ile Ser Phe Leu Pro Phe Asn Ser Ser Asp
 1               5                  10                  15      
Asp Val Gln Glu Arg Arg
            20          


<210> 2478
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2478
Lys Ala Asp Asn His Thr Ala His Arg Ile Ala Asp Gln Thr Ala Leu
 1               5                  10                  15      
Arg Val Pro Ser Gln Ala Glu Ser Ser Ile Phe Ser Gln Ala Thr Asn
            20                  25                  30          
Gly
    


<210> 2479
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2479
Lys Ala Asp Ile Leu Leu Asp Cys Leu Leu Asp Glu Asp Pro Glu Asn
 1               5                  10                  15      
Gln Thr Leu Arg Lys Asp Tyr Glu Lys Thr
            20                  25      


<210> 2480
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2480
Lys Ala Asp Glu Thr Val Thr Glu Met Asn Phe Ser Asn Glu Tyr Asn
 1               5                  10                  15      
Lys Ser Glu Leu Met Leu Gln Glu Asn Gln Met Ile Ala Asp Gly Lys
            20                  25                  30          
Glu
    


<210> 2481
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2481
Lys Ala Ala His Asn Asn Ser Glu Asn Ile Pro Leu His Lys Ser
 1               5                  10                  15  


<210> 2482
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2482
Lys Ala Ala Ala Glu Lys Leu Ser Ser Leu Glu Asn Ser Ser Asn Lys
 1               5                  10                  15      
Asn Glu Lys Glu
            20  


<210> 2483
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2483
Ile Trp Glu Lys Ala Asn Leu Thr Leu Pro Arg Gly
 1               5                  10          


<210> 2484
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2484
Ile Gln Ile Arg Asn Val Ser Gln Leu Pro Ala Thr Trp Arg Met Lys
 1               5                  10                  15      
Glu
    


<210> 2485
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2485
Ile Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp
 1               5                  10                  15      
Ala Asn Thr Gly Asp Arg Gly
            20              


<210> 2486
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2486
Ile Phe Pro Leu Leu Tyr Val Glu Leu Asn Asp Ser Ala Lys Gln
 1               5                  10                  15  


<210> 2487
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2487
Ile Glu Val Asp Glu Asn Gly Thr Leu Asp Leu Ser Met His Lys His
 1               5                  10                  15      
Arg Lys
        


<210> 2488
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2488
His Ser Asp His Asp Asn Ser Thr Ser Leu Asn Gly Gly Lys Arg
 1               5                  10                  15  


<210> 2489
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2489
His Arg Val Leu His Asn Ser Leu Gly Asn Ile Ser Met Leu Pro Cys
 1               5                  10                  15      
Ser Ser Phe Thr Pro Asn Trp Pro Val Gln Asn Pro Asp Ser Arg Lys
            20                  25                  30          


<210> 2490
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2490
His Leu Arg Gln Met Gly Val Thr Glu Trp Ser Val Asn Gly Ser Pro
 1               5                  10                  15      
Ile Asp Thr Leu Arg Glu
            20          


<210> 2491
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2491
His Gly Arg Tyr Ile Ala Ser Ile Met Glu Asn Gly Ser Leu Asn Ile
 1               5                  10                  15      
Tyr Ser Val Gln Ala Leu Thr Gln Glu Ile Asn Lys Glu
            20                  25                  


<210> 2492
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2492
Gly Val Ser Leu Ser Ser Tyr Leu Glu Gly Leu Met Ala Ser Thr Ile
 1               5                  10                  15      
Ser Ser Asn Ala Ser Lys Gly Arg Glu Ala Met Glu Trp Val Ile His
            20                  25                  30          
Lys Leu
        


<210> 2493
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2493
Gly Val Leu Thr Leu Ala Asn Asn Val Thr Pro Ala Lys Asp
 1               5                  10                  


<210> 2494
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2494
Gly Asn Tyr Asn Asn Ser Ser Asn Phe Gly Thr Met Lys Val Gly Asn
 1               5                  10                  15      
Phe Gly Gly Arg Asn Ser Gly Ser Tyr Gly Val Gly Gly Gln Tyr Phe
            20                  25                  30          
Ala Lys Pro Arg His
        35          


<210> 2495
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2495
Gly Leu Asn Thr Thr Gly Val Pro Ala Ser Leu Pro Val Glu Phe Thr
 1               5                  10                  15      
Ile Asp Ala Lys Asp
            20      


<210> 2496
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2496
Gly Lys Gly Phe Ile Cys Glu Phe Cys Gln Asn Thr Thr Val Ile Phe
 1               5                  10                  15      
Pro Phe Gln Thr Ala Thr Cys Arg Arg Cys
            20                  25      


<210> 2497
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2497
Gly Ile Lys Val Lys Asn His Ser Gly Gly Gly Met Ser Leu Thr His
 1               5                  10                  15      
Asn Lys Asn Phe Arg Lys Leu
            20              


<210> 2498
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2498
Gly His Lys Gln Ile Ser Ser Ser Ser Thr Gly Cys Leu Ser Ser Pro
 1               5                  10                  15      
Asn Ala Thr Val Gln Ser Pro Lys His
            20                  25  


<210> 2499
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2499
Gly Phe Asp Glu Asp Met Val Ile Gln Ala Leu Gln Lys Thr Asn Asn
 1               5                  10                  15      
Arg Ser Ile Glu Ala Ala Ile Glu Phe Ile Ser Lys Met
            20                  25                  


<210> 2500
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2500
Gly Glu Asn Gly Thr Leu Ser Arg Glu
 1               5                  


<210> 2501
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2501
Gly Glu Cys Gly Lys Cys Phe Asn Asn Asn Ser Asn Leu Ser Lys His
 1               5                  10                  15      
Lys Lys
        


<210> 2502
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2502
Gly Asp Tyr Glu Pro Ile Asp Ala Thr Gly Phe Ile Asn Ile Ser Ser
 1               5                  10                  15      
Leu Arg Leu Lys Glu
            20      


<210> 2503
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2503
Gly Asp Ser Ser His Cys Ser Asn Ala Ser Thr His Ser Asn Gln Glu
 1               5                  10                  15      
Ala Gly Pro Ser Asn Lys Arg Thr
            20                  


<210> 2504
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2504
Gly Cys Gly Gly Gly Gly Ser Tyr Ser Ala Ser Ser Ser Ser Ala Ala
 1               5                  10                  15      
Leu Pro Val Asn Lys Ser Lys Met
            20                  


<210> 2505
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2505
Phe Thr Val Phe Thr Asn Asn Thr His
 1               5                  


<210> 2506
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2506
Phe Thr Gln Asn Leu Leu Leu Glu Tyr Thr Asn Gln Thr Thr Gln Ala
 1               5                  10                  15      
Arg Pro
        


<210> 2507
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2507
Phe Ser Tyr Ala Thr Ala Ala Gln Asn Asn Thr Val Thr Asp Pro Lys
 1               5                  10                  15      
Asn
    


<210> 2508
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2508
Phe Asn Glu His Met Thr Asn Ser Thr Met Ser Pro Gly Thr Val Gly
 1               5                  10                  15      
Gln Ser Leu Lys Ser
            20      


<210> 2509
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2509
Phe Ala Pro Phe Leu Asn Asn Ser Pro Gln Gln Asn Pro Ala Ala Gln
 1               5                  10                  15      
Ile Pro Ala Arg Gln
            20      


<210> 2510
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2510
Glu Val Phe Glu Asn Leu Asp Gly Asp Leu Gly Asn Ser Thr Glu Lys
 1               5                  10                  15      
Gln
    


<210> 2511
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2511
Glu Ser Phe Val Glu Met Ser Ser Ser Ser Phe Met Gly Ile Ser Asn
 1               5                  10                  15      
Met Thr Gln Leu Glu Ser Ser Thr Ser Lys Met
            20                  25          


<210> 2512
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2512
Glu Asn Asn Val Ser Lys Gly Asp Asn Gly Glu Leu Ala Lys Glu
 1               5                  10                  15  


<210> 2513
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2513
Glu Asn Asp Ser Glu Asp Gln Asp Val Ala Met Lys Ser
 1               5                  10              


<210> 2514
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2514
Glu Ile Leu Gly Phe Asn Ser Lys Gly Glu Val His Gly Ile Asn Gly
 1               5                  10                  15      
Thr Gln Trp Gly Gln Thr Leu Arg Met
            20                  25  


<210> 2515
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2515
Glu Ile Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp Val Leu Phe
 1               5                  10                  15      
Thr Gly Arg Glu
            20  


<210> 2516
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2516
Glu Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser
 1               5                  10                  15      
Ser Thr Ala Thr Val Val Ser
            20              


<210> 2517
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2517
Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro Asp Gly
 1               5                  10                  15      
Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg
            20                  25                  


<210> 2518
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2518
Glu Gly Glu Lys Asp Pro Trp Gly Val Ser Met Met Asn Thr Ser Phe
 1               5                  10                  15      
Ala Gly Gly Gln Ile His Gln Asp Ile
            20                  25  


<210> 2519
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2519
Glu Phe Lys Asn Asn Phe Leu Asn Ile Asp Pro Ile Thr Met Ala Tyr
 1               5                  10                  15      
Ser Leu Asn Ser Ser Ala Gln Glu Arg Leu
            20                  25      


<210> 2520
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2520
Glu Glu Asn Glu Thr Thr Thr Thr Ser Ala Phe Thr Ile Gln Glu Tyr
 1               5                  10                  15      
Phe Ala Lys Arg Met Ala Ala Leu Lys Asn
            20                  25      


<210> 2521
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2521
Glu Glu Ala Asp Val Asp Met Glu Pro Asn Val Ser Val Tyr Ser Gly
 1               5                  10                  15      
Leu Lys Glu
            


<210> 2522
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2522
Glu Ala Pro Met Phe Thr Gln Pro Leu Val Asn Thr Tyr Ala Ile Ala
 1               5                  10                  15      
Gly Tyr Asn Ala Thr Leu Asn Cys Ser Val Arg Gly
            20                  25              


<210> 2523
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2523
Asp Ser Phe Ser Gln Ala Ser Asn Val Thr Ser Gln Leu Pro Gly Phe
 1               5                  10                  15      
Pro Lys Tyr
            


<210> 2524
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2524
Asp Ser Asp Met Asp Pro Asn Ser Ser Gly Glu Gly Val Asn Ser Val
 1               5                  10                  15      
Ser Ser Ser Ile
            20  


<210> 2525
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2525
Asp Gln Tyr Gly Lys Asn Phe Ser Gln Ser
 1               5                  10  


<210> 2526
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2526
Asp Pro Leu Thr Phe Asn Phe Ile Ser Ser Leu Lys Ala Ile Cys Thr
 1               5                  10                  15      
Glu Ile Ala Asn Cys Ser Leu Lys Val
            20                  25  


<210> 2527
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2527
Asp Lys Met Ile Glu Asn His Asn Ile Ser Thr Pro Phe Ser Cys Gln
 1               5                  10                  15      
Phe Cys Lys Glu
            20  


<210> 2528
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2528
Asp Lys Ala Pro Val Asn Gly Thr Glu Gln Thr Gln Lys Thr
 1               5                  10                  


<210> 2529
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2529
Asp Asp Ser Thr Glu Ala His Glu Gly Asp Pro Thr Asn Gly Ser Gly
 1               5                  10                  15      
Glu Gln Ser Lys Thr
            20      


<210> 2530
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2530
Asp Asp Ser Gly Ala Thr Leu Leu Ser Ala Asn Gln Thr Leu Arg Arg
 1               5                  10                  15      
Leu His Asn Arg Arg Thr
            20          


<210> 2531
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2531
Asp Asp Arg Gly Ser Tyr Thr Ala Ser Ile Tyr Gln Asn Tyr Met Gly
 1               5                  10                  15      
Asn Ser Phe Ser Gly Tyr Ser His Ser Pro Pro Leu Leu Gln Val Asn
            20                  25                  30          
Arg Ser
        


<210> 2532
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2532
Asp Asp Asn Ser Thr Phe Asn Ser Thr Gln Ser His Met Asp Trp Gly
 1               5                  10                  15      
Lys Val
        


<210> 2533
<211> 41
<212> PRT
<213> Homo sapiens

<400> 2533
Asp Asp Asp Leu Ile Ile Ser Gln Asp Thr Asp Ile Ile Gln Asp Met
 1               5                  10                  15      
Val Ala Gly Glu Asn Thr Ser Glu Ala Gly Ser Glu Asp Glu Gly Glu
            20                  25                  30          
Val Ser Leu Pro Glu Gln Pro Lys Val
        35                  40      


<210> 2534
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2534
Asp Ala Lys Ala Gln Leu Ala Leu Ser Ser Ser Ala Asn Gln Ser Lys
 1               5                  10                  15      
Glu
    


<210> 2535
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2535
Cys Tyr Pro Asp Asn Pro Ala Asn Arg Ser Leu Val Leu Pro Trp Ser
 1               5                  10                  15      
Phe Pro Leu Glu Trp Ala Pro Gln Asn Leu Thr Arg Trp
            20                  25                  


<210> 2536
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2536
Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Thr Asp Lys
 1               5                  10                  15      
His
    


<210> 2537
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2537
Cys Gln Ala Glu Ala Ala Ala Ala Ala Asn Gly Thr Gly Gly Glu Glu
 1               5                  10                  15      
Asp Asp Gly Pro Ala Ala Glu Leu Leu Glu Lys Leu
            20                  25              


<210> 2538
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2538
Cys Leu Gln Lys Gly Ser Leu Thr Ile Gln Gln Val Asn Asp Leu Leu
 1               5                  10                  15      
Asp Ser Ile Ala Ser Asn Asn Ser Ala Lys Arg
            20                  25          


<210> 2539
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2539
Cys Leu Asn Leu Ser Asn Thr Thr Ile Thr Asn Arg Thr
 1               5                  10              


<210> 2540
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2540
Cys Leu Ile Pro Asn Glu Thr Lys Thr Pro Gly Val Met Asp His Tyr
 1               5                  10                  15      
Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg
            20                  25                  30          
Ile
    


<210> 2541
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2541
Cys Ile Ile Gln Met Gln Gly Asn Ser Thr Ser Ile Ile Asn Pro Lys
 1               5                  10                  15      
Asn
    


<210> 2542
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2542
Cys Phe Tyr Asn Leu Glu Leu Gly Asp Met Ser Leu Ser Asp Asn Ala
 1               5                  10                  15      
Ser Met Cys Leu Met Ser Ile Ile Lys Lys
            20                  25      


<210> 2543
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2543
Cys Phe Pro Thr Leu Ser Asp Phe Leu Thr Glu Ile Asn Ser Thr Val
 1               5                  10                  15      
Asp Lys Asp
            


<210> 2544
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2544
Cys Phe Glu Asn Val Thr Ser Ile Met Phe Leu Val Ala Leu Ser Glu
 1               5                  10                  15      
Tyr Asp Arg Val Leu Val Glu Ser Asp Asn Glu Asn Arg Met Glu Glu
            20                  25                  30          
Ser Lys Ala
        35  


<210> 2545
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2545
Cys Ala Leu Ser Leu Phe Leu Met Ala Val Asn Ile Lys Thr Pro Val
 1               5                  10                  15      
Val Val Glu Asn Ile Thr Leu Met Cys Leu Arg Ile
            20                  25              


<210> 2546
<211> 8
<212> PRT
<213> Homo sapiens

<400> 2546
Ala Tyr Ser Asn Glu Thr Lys Val
 1               5              


<210> 2547
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2547
Ala Tyr Leu Met Glu Pro Leu Cys Ile Ser Ser Asn Glu Ser Ser Glu
 1               5                  10                  15      
Gly Cys Cys Pro Pro Ser Gly Thr Arg Gln
            20                  25      


<210> 2548
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2548
Ala Val Ala Ala Gly Thr Pro Asn Thr Ser Gly Ser Ile His Glu Asn
 1               5                  10                  15      
Pro Pro Lys Ala
            20  


<210> 2549
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2549
Ala Thr Asn Glu Thr Asn Val Asn Ile Pro Gln
 1               5                  10      


<210> 2550
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2550
Ala Arg Thr Thr Phe Asn Phe Ser Ile Gly Val Leu Gln Ala Glu Cys
 1               5                  10                  15      
Leu Thr Ser Lys Gly Arg Glu
            20              


<210> 2551
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2551
Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met
 1               5                  10                  15  


<210> 2552
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2552
Ala Leu Leu Asn Asn Ser His Tyr Tyr His Met Ala His Gly Thr Asp
 1               5                  10                  15      
Phe Ala Ser Arg Gly
            20      


<210> 2553
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2553
Ala Lys Glu Asn Glu Asn Ser Ser Pro Val Ala Gly Ala Phe Gly Val
 1               5                  10                  15      
Phe Ser Thr Ile Ser Thr Ala Val Gln Ser Thr Gly Lys Ser
            20                  25                  30  


<210> 2554
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2554
Ala Lys Glu Ala Ala Gly Ala Ser Lys Ala Leu Asn Val Thr
 1               5                  10                  


<210> 2555
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2555
Ala Ile Tyr Phe Glu Asn Leu Gln Asn Ser Ser Asn Asp Leu Gly Asp
 1               5                  10                  15      
His Ser Met Lys Glu Arg Asp
            20              


<210> 2556
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2556
Ala His Val Cys Asn Asp Thr Asn Lys Met Thr Leu Ile Asn Pro Gln
 1               5                  10                  15      
Gly Ala Lys Leu Asn Ile Tyr Lys Arg Lys Val
            20                  25          


<210> 2557
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2557
Ala His Asn Met Ser Gly Pro Asn Ser Ser Ser Glu Trp Ser Ile Glu
 1               5                  10                  15      
Gly Arg Arg Leu
            20  


<210> 2558
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2558
Ala His Ala Ala Ser Thr Glu Glu Lys Glu Ala Gly Val Gly Asn Gly
 1               5                  10                  15      
Thr Cys Ala Pro Val Arg Leu
            20              


<210> 2559
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2559
Ala Gly Gln Val Leu Glu Asn Leu Pro Pro Ile Gly Val Phe Trp Asp
 1               5                  10                  15      
Ile Glu Asn Cys Ser Val Pro Ser Gly Arg Ser
            20                  25          


<210> 2560
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2560
Ala Gly Phe Gly Asn Asn Phe Thr Thr Val Asp Asn Lys Ser
 1               5                  10                  


<210> 2561
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2561
Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile Thr Val
 1               5                  10                  15      
Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln
            20                  25      


<210> 2562
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2562
Ala Asp Lys Ala Ser Asp Thr Ser Ser Glu Thr Val Phe Gly Lys Arg
 1               5                  10                  15      
Gly His Val Leu Gly Asn Gly Ser Gln Val Thr Gln Ala Ala Asn Ser
            20                  25                  30          
Gly Cys Ser Lys Ala
        35          


<210> 2563
<211> 38
<212> PRT
<213> Homo sapiens

<400> 2563
Ala Ala Ser Ser Ile Trp Ser Pro Ala Ser Ile Ser Pro Gly Ser Ala
 1               5                  10                  15      
Pro Ala Ser Val Ser Val Pro Glu Pro Leu Ala Ala Pro Ser Asn Thr
            20                  25                  30          
Ser Cys Met Gln Arg Ser
        35              


<210> 2564
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2564
Ala Ala Gln Asn Asn Thr Val Thr Val Pro Lys Asn
 1               5                  10          


<210> 2565
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2565
Ala Ala Lys Cys Ile Val Asn Asn Val Ser Ala Glu Thr Val Gln Thr
 1               5                  10                  15      
Val Arg Tyr
            


<210> 2566
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2566
Met Val Tyr Leu Thr Ser Tyr Leu Leu Pro Ser Leu Met Ser Asn Thr
 1               5                  10                  15      
Ser Leu Ser Ala Lys Asp Ile Lys Lys Ile
            20                  25      


<210> 2567
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2567
Met Val Thr Val Thr Leu Lys Asp Ile Asn Leu Ser Trp Leu Asp Val
 1               5                  10                  15      
Asp
    


<210> 2568
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2568
Met Val Asp Leu Leu Ser Met Ser Gln Asn Ile Ser Pro Tyr Lys Asn
 1               5                  10                  15      
Pro Met Arg Phe
            20  


<210> 2569
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2569
Met Thr Val Arg Asn Ile Ala Ser Ile Cys Asn Met Gly Thr Asn Ala
 1               5                  10                  15      
Ser Ala Leu Glu Lys Asp
            20          


<210> 2570
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2570
Met Thr Gly Ser Asn Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln
 1               5                  10                  15      
Arg Cys
        


<210> 2571
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2571
Met Ser Arg Ile Asn Lys Tyr Leu Phe Ser Asn Ser Asp Ser Asn Phe
 1               5                  10                  15      
Ser His Phe Ser Val Ser Asn Val Ser
            20                  25  


<210> 2572
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2572
Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu
 1               5                  10                  15      
Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln
            20                  25              


<210> 2573
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2573
Met Asn Arg Tyr Thr Thr Met Arg Gln Leu Gly Asp Gly Thr Tyr Gly
 1               5                  10                  15      
Ser Val Leu Met Gly Lys Ser Asn Glu Ser Gly Glu Leu Val Ala Ile
            20                  25                  30          
Lys Arg Met
        35  


<210> 2574
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2574
Met Asn Gln Phe Gly Pro Ser Ala Leu Ile Asn Leu Ser Asn Phe Ser
 1               5                  10                  15      
Ser Ile Lys Pro Glu Pro Ala Ser Thr Pro Pro Gln Gly Ser Met Ala
            20                  25                  30          
Asn Ser
        


<210> 2575
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2575
Met Asn Asn Pro Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp
 1               5                  10                  15      
Gly Asn Thr Gly Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln
            20                  25                  30      


<210> 2576
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2576
Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr
 1               5                  10                  15      
Ser Ser Asp Phe Lys Asp
            20          


<210> 2577
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2577
Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn
 1               5                  10                  15      
Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg
            20                  25                  30          
Asp
    


<210> 2578
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2578
Met Met Ala Thr Pro Asn Gln Thr Ala Cys Asn Ala Glu Ser Pro Val
 1               5                  10                  15      
Ala Leu Glu Glu Ala Lys Thr
            20              


<210> 2579
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2579
Met Leu Thr Gly Val Leu Leu Ala Asn Gly Thr Leu Asn Ala Ser Ile
 1               5                  10                  15      
Leu Asn Ser Leu Tyr Asn Glu Asn Leu Val Lys Glu
            20                  25              


<210> 2580
<211> 8
<212> PRT
<213> Homo sapiens

<400> 2580
Met Glu Asn Leu Thr Lys His Ser
 1               5              


<210> 2581
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2581
Met Glu Asn Phe Thr Ala Leu Phe Gly Ala Gln Ala Asp Pro Pro Pro
 1               5                  10                  15      
Pro Pro Thr Ala Leu Gly Phe Gly Pro Gly Lys Pro
            20                  25              


<210> 2582
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2582
Met Glu Asn Phe Ser Leu Leu Ser Ile Ser Gly Pro Pro Ile Ser Ser
 1               5                  10                  15      
Ser Ala Leu Ser Ala Phe Pro Asp Ile Met Phe Ser
            20                  25              


<210> 2583
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2583
Met Asp Ser Ser Cys His Asn Ala Thr Thr Lys Met Leu Ala Thr Ala
 1               5                  10                  15      
Pro Ala Arg Gly Asn Met Met Ser Thr Ser Lys Pro
            20                  25              


<210> 2584
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2584
Met Asp Pro Asn Cys Ser Cys Ser Thr Ser Ser Ser Cys Thr Cys Thr
 1               5                  10                  15      
Thr Ser Ser Lys Ser Arg Glu
            20              


<210> 2585
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2585
Met Asp Pro Asn Cys Ser Cys Ser Thr Ile Gly Ser Cys Ala Cys Ala
 1               5                  10                  15      
Gly Ser Cys Lys Cys
            20      


<210> 2586
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2586
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr Cys Ala
 1               5                  10                  15      
Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys
            20                  25      


<210> 2587
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2587
Met Asp Leu Ser Asn Asn Thr Met Ser Leu Ser Val Arg Thr Pro Gly
 1               5                  10                  15      
Leu Ser Arg Arg
            20  


<210> 2588
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2588
Met Asp Asp Leu Cys Glu Ala Asn Gly Thr Phe Ala Ile Ser Leu Phe
 1               5                  10                  15      
Lys Ile
        


<210> 2589
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2589
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met
 1               5                  10                  15      
Cys Lys Ala
            


<210> 2590
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2590
Met Ala Tyr Pro Gly Tyr Gly Gly Gly Phe Gly Asn Phe Ser Ile Gln
 1               5                  10                  15      
Val Pro Gly Met Gln Met Gly Gln
            20                  


<210> 2591
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2591
Met Ala Ser Gln Leu Gln Glu Lys Cys Ile Ala Phe Ile Val Asp Asn
 1               5                  10                  15      
Phe Ser Lys Ile
            20  


<210> 2592
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2592
Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser
 1               5                  10                  15      
Arg Val
        


<210> 2593
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2593
Met Ala His Ser Gln Asn Ser Leu Glu Leu Pro Ile Asn Ile Asn Ala
 1               5                  10                  15      
Thr Gln Ile Thr Thr Ala Tyr Gly His Arg Ala
            20                  25          


<210> 2594
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2594
Trp Thr Pro Val Asn Ile Ser Asp Asn Gly Asp His Tyr Glu Gln Arg
 1               5                  10                  15      
Phe
    


<210> 2595
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2595
Val Gln Val Cys Ser Leu Pro Ala Cys Gly Gly Asn His Gln Asn Ser
 1               5                  10                  15      
Thr Val Arg Ala
            20  


<210> 2596
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2596
Thr Thr Thr Ala Thr Phe Thr Thr Asn Thr Thr Thr Thr Ile Thr Ser
 1               5                  10                  15      
Gly Phe Thr Val Asn Gln Asn Gln Leu Leu Ser Arg Gly
            20                  25                  


<210> 2597
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2597
Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys Cys His Leu Thr
 1               5                  10                  15      
Tyr Lys Met Ser Glu Lys Arg Thr
            20                  


<210> 2598
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2598
Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser
 1               5                  10                  15      
Pro Thr Pro Ser Ser Pro Asn Arg Thr
            20                  25  


<210> 2599
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2599
Ser Phe Ser Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro Asn Met Ser
 1               5                  10                  15      
Pro Thr
        


<210> 2600
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2600
Ser Glu Glu Asn Ser Thr Phe Arg Asn
 1               5                  


<210> 2601
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2601
Arg Tyr Asp Pro Phe Pro Ala Gly Asp Pro Glu Pro Arg Ala Ala Pro
 1               5                  10                  15      
Asn Asn Ser Ala Asp Pro Arg Val Arg
            20                  25  


<210> 2602
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2602
Arg Trp Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser
 1               5                  10                  15      
Gln
    


<210> 2603
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2603
Arg Trp Gln Ala Leu Val Gln Val Gln Pro Ser Val Asp Pro Thr Asn
 1               5                  10                  15      
Ala Thr Gly Leu Asp Gly Arg Glu
            20                  


<210> 2604
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2604
Arg Val Val Asn Glu Ser Thr Val Cys Leu Met Asn His Glu Arg Arg
 1               5                  10                  15      
Gln
    


<210> 2605
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2605
Arg Val Arg Arg Ala Ser Cys Glu Pro Ala Asn Gly Ser Gly Arg Ser
 1               5                  10                  15      


<210> 2606
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2606
Arg Val Asn Arg Ser Val His Glu Trp Ala Gly Gly Gly Gly Gly Gly
 1               5                  10                  15      
Gly Gly Ala Thr Tyr Val Phe Lys Met
            20                  25  


<210> 2607
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2607
Arg Val Glu Tyr Thr Gly His Pro Leu Glu Ile Ala Val Phe Leu Asn
 1               5                  10                  15      
Tyr Cys Thr Val Cys Asn Val Thr Lys Lys
            20                  25      


<210> 2608
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2608
Arg Thr Leu Gln Gln Leu Tyr Glu Ala Tyr Ala Ser Lys Ser Asn Asn
 1               5                  10                  15      
Thr Ala Tyr Leu Ile Tyr Asn Asp Gly Val Pro Lys Pro
            20                  25                  


<210> 2609
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2609
Arg Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg
 1               5                  10                  15      
Leu
    


<210> 2610
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2610
Arg Thr Ile Asn Val Ser Asn Leu Tyr Val Gly Gly Ile Pro Glu Gly
 1               5                  10                  15      
Glu Gly Thr Ser Leu Leu Thr Met Arg Arg Ser
            20                  25          


<210> 2611
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2611
Arg Thr Cys Tyr Tyr Pro Thr Thr Val Cys Leu Pro Gly Cys Leu Asn
 1               5                  10                  15      
Gln Ser Cys Gly Ser Ser Cys
            20              


<210> 2612
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2612
Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu Val Thr
 1               5                  10                  15      
Ser Val Thr Asn Val
            20      


<210> 2613
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2613
Arg Ser Thr Glu Glu Pro Thr Ala Pro Ala Ser Pro Gln Pro Pro Asn
 1               5                  10                  15      
Asp Ser Arg Leu
            20  


<210> 2614
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2614
Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln Asn Gly
 1               5                  10                  15      
Ser Leu Gln Glu Leu His Tyr Leu Met Thr Val Met Glu Arg Leu
            20                  25                  30      


<210> 2615
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2615
Arg Ser Met Pro Glu Ala Ser Asp Gln Glu Glu His Leu Ser Pro Leu
 1               5                  10                  15      
Asp Phe Leu His Ser Ala Asn Phe Ser Leu Gly Ser Ile Asn Gln Arg
            20                  25                  30          
Leu Asn Lys Arg Glu
        35          


<210> 2616
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2616
Arg Ser Leu His Asn Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln
 1               5                  10                  15      
Thr Val Thr Ile Glu Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu
            20                  25                  30          
Ser Arg Glu
        35  


<210> 2617
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2617
Arg Ser Phe Asn Gln Ser Leu His Ser Leu Thr Gln Ala Ile Arg Asn
 1               5                  10                  15      


<210> 2618
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2618
Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu Gly Leu Asn
 1               5                  10                  15      
Leu Ser Phe Thr Ala Ile Cys
            20              


<210> 2619
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2619
Arg Ser Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr
 1               5                  10                  15      
Glu Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly
            20                  25                  30          
Ala Gln Arg Ser
        35      


<210> 2620
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2620
Arg Arg Ser Leu Glu Gln His Gly Leu Pro Trp Ala Ile Ile Ser Ile
 1               5                  10                  15      
Pro Val Asn Val Thr Ser Ile Pro Thr Phe Glu Leu Leu Gln Pro Pro
            20                  25                  30          
Trp Thr Phe Trp
        35      


<210> 2621
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2621
Arg Arg Gln Gln Ser Arg Asn Arg Ser
 1               5                  


<210> 2622
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2622
Arg Arg Leu Glu Gly Thr Asn Val Thr Val Asn Val Leu His Pro Gly
 1               5                  10                  15      
Ile Val Arg Thr
            20  


<210> 2623
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2623
Arg Arg Lys Phe Val Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr
 1               5                  10                  15      
Gln Ser Val Gln Leu Lys Glu Lys Arg
            20                  25  


<210> 2624
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2624
Arg Arg Phe Gly Ile Leu Ser Asn Cys Asn His Thr Tyr Cys Leu Lys
 1               5                  10                  15      
Cys Ile Arg Lys Trp
            20      


<210> 2625
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2625
Arg Gln Thr Asn Glu Ser Leu Leu Ile Leu Arg Ala Ile Pro Glu Gly
 1               5                  10                  15      
Ile Arg Asp Lys Gly
            20      


<210> 2626
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2626
Arg Pro Pro Ser Ala Pro Gln Asn Leu Ile Phe Asn Ile Asn Gln Thr
 1               5                  10                  15      
Thr Val Ser Leu Glu Trp Ser Pro Pro Ala Asp Asn Gly Gly Arg Asn
            20                  25                  30          


<210> 2627
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2627
Arg Asn Pro Pro Ala Phe Gly Asn Val Ser Val Ile Ala Leu Glu Leu
 1               5                  10                  15      
Leu Asn Ser Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Gln
            20                  25                  30          
Phe Lys Ser
        35  


<210> 2628
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2628
Arg Asn Asn Ile Ser Lys Leu Thr Asp Gly Ala Phe Trp Gly Leu Ser
 1               5                  10                  15      
Lys Met His Val Leu His Leu
            20              


<210> 2629
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2629
Arg Asn Met Ala Asn Gly Gln Pro His Ser Val Asn Ile Thr Arg His
 1               5                  10                  15      


<210> 2630
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2630
Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val Ala Asn Tyr
 1               5                  10                  15      
Val Asp Gln Val Val Asn Ser Ala Gly Asp Ala His Gly
            20                  25                  


<210> 2631
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2631
Arg Asn Lys Glu Val Asn Ile Ser Ala Val Val Trp Pro Ser Gln
 1               5                  10                  15  


<210> 2632
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2632
Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val Thr Val Thr
 1               5                  10                  15      
Met Lys Lys Cys
            20  


<210> 2633
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2633
Arg Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu
 1               5                  10                  15      
Thr Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu Gly Lys Ala
            20                  25                  30          


<210> 2634
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2634
Arg Asn Gly Ser Ala Asn Arg Asn Ser Ser His Arg Thr Ala Ala Gln
 1               5                  10                  15      
Pro Ala Glu Thr Pro Glu Asp Val Pro Gly Ser Leu Asp Asp Gly Ala
            20                  25                  30          
Asp Cys Glu Ala Val
        35          


<210> 2635
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2635
Arg Asn Asp Ser Ile Tyr Glu Ala Ser Ser Leu Tyr Gly Ile Ser Ala
 1               5                  10                  15      
Met Asp Gly Val Pro Phe Thr Leu His Pro Arg Phe
            20                  25              


<210> 2636
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2636
Arg Met Leu Arg Phe Ile Gln Glu Val Asn Thr Thr Thr Arg Ser
 1               5                  10                  15  


<210> 2637
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2637
Arg Leu Val Val Gly Asp Phe Ser Asp Tyr Asn Asn Ser Tyr Val Gly
 1               5                  10                  15      
Ala Phe Ala Asp Ala Arg Ser
            20              


<210> 2638
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2638
Arg Leu Pro Gln Asp Gly Asp Asn Val Thr Val Glu Asn Gly Gln Leu
 1               5                  10                  15      
Leu Leu Leu Asp Thr Asn Thr Ser Ile Leu Asn Leu Leu His Ile Lys
            20                  25                  30          
Gly
    


<210> 2639
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2639
Arg Leu Asn Asn Ile Thr Met Trp Leu Asn Asn Ser Asn Pro Pro Val
 1               5                  10                  15      
Thr
    


<210> 2640
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2640
Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro Ser Leu Gly
 1               5                  10                  15      
Ser Gln Pro Leu Tyr Arg Ser
            20              


<210> 2641
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2641
Arg Leu Leu Pro Ile Leu Ser Gln Gln Ser Thr Ile Asn Leu Ser His
 1               5                  10                  15      
Asn Pro Leu Asp Cys Thr Cys Ser Asn Ile His Phe Leu Thr Trp Tyr
            20                  25                  30          
Lys Glu
        


<210> 2642
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2642
Arg Leu Lys Thr Glu Tyr Asn Ile Thr Leu Arg Val
 1               5                  10          


<210> 2643
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2643
Arg Leu Glu Val His Tyr His Asn Pro Leu Val Ile Glu Gly Arg Asn
 1               5                  10                  15      
Asp Ser Ser Gly Ile Arg Leu
            20              


<210> 2644
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2644
Arg Leu Asp Leu Ser Gly Asn Ala Leu Thr Glu Asp Met Ala Ala Leu
 1               5                  10                  15      
Met Leu Gln Asn Leu Ser Ser Leu Arg Ser
            20                  25      


<210> 2645
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2645
Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val Ile Cys
 1               5                  10                  15      
Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala
            20                  25                  


<210> 2646
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2646
Arg Lys Met Ser Ala Pro Ala Gln Pro Pro Ala Glu Gly Thr Glu Gly
 1               5                  10                  15      
Thr Ala Pro Gly Gly Gly Pro Pro Gly Pro Pro Pro Asn Met Thr Ser
            20                  25                  30          
Asn Arg Arg
        35  


<210> 2647
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2647
Arg Lys Gly Asn Ser Leu Asp Ile Pro Val Ala Val Thr Ile Phe Phe
 1               5                  10                  15      
Gly Ala Asn Asp Ser Ala Leu Lys Asp
            20                  25  


<210> 2648
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2648
Arg Lys Asp Ile Asn Thr Thr Ala Gln Asn
 1               5                  10  


<210> 2649
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2649
Arg Lys Ala Val Pro Met Ala Pro Ala Pro Ala Ser Pro Gly Ser Ser
 1               5                  10                  15      
Asn Asp Ser Ser Ala Arg Ser
            20              


<210> 2650
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2650
Arg Ile Asn Asn Gly Gly Cys Gln Asp Leu Cys Leu Leu Thr His Gln
 1               5                  10                  15      
Gly His Val Asn Cys Ser Cys Arg Gly
            20                  25  


<210> 2651
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2651
Arg Ile Asn Lys Leu Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu
 1               5                  10                  15      
Asn Pro His Ile Gly Tyr Asp Lys Ala
            20                  25  


<210> 2652
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2652
Arg Ile Leu Val Asn Leu Ser Met Val Glu Asn Lys Leu Val Glu Leu
 1               5                  10                  15      
Glu His Thr Leu Leu Ser Lys Gly
            20                  


<210> 2653
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2653
Arg Ile Phe Val Gly Gly Ile Asp Phe Lys Thr Asn Glu Ser Asp Leu
 1               5                  10                  15      
Arg Lys
        


<210> 2654
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2654
Arg His Pro Gln Val Leu Gln Ala Thr Gln Glu Thr Leu Gln Arg His
 1               5                  10                  15      
Gly Val Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly
            20                  25              


<210> 2655
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2655
Arg His Leu Thr Ser Leu Asn Leu Val Gln Asn Asn Phe Ser Pro Lys
 1               5                  10                  15      
Gly
    


<210> 2656
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2656
Arg Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr
 1               5                  10                  15      
Pro Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr
            20                  25                  30  


<210> 2657
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2657
Arg Gly Glu Asn Ala Tyr Ser Thr Val Leu Asn Ile Ser Gln Ser Ala
 1               5                  10                  15      
Asn Leu Gln Phe Ala Ser Leu Ile Gln Lys Glu
            20                  25          


<210> 2658
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2658
Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro His Ala Thr Thr Ala
 1               5                  10                  15      
Asn Thr Ser Val Leu
            20      


<210> 2659
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2659
Arg Phe Ala Asn Leu Thr Pro Glu Glu Phe Val Gly Asp Tyr Trp Arg
 1               5                  10                  15      
Asn
    


<210> 2660
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2660
Arg Glu Arg Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp
 1               5                  10                  15      
Asn Ala Ser Ser Lys Glu
            20          


<210> 2661
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2661
Arg Glu Asn Phe Thr Gln Thr Leu Pro Lys Met
 1               5                  10      


<210> 2662
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2662
Arg Glu Leu Gln Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys
 1               5                  10                  15      
Val Pro Thr Leu Asp Gly Pro Thr Cys Tyr Cys
            20                  25          


<210> 2663
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2663
Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile
 1               5                  10                  15      
Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys
            20                  25                  


<210> 2664
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2664
Arg Asp Ala Gly Gly Glu Leu Ala Asn Leu Ser Gln Ala Glu Leu Val
 1               5                  10                  15      
Asp Leu Val Gln Trp Thr Asp Leu Ile Leu Phe Asp Tyr Leu Thr Ala
            20                  25                  30          
Asn Phe Asp Arg Leu
        35          


<210> 2665
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2665
Arg Cys Lys Asn Gln Asn Thr Phe Leu Leu Thr Thr Phe Ala Asn Val
 1               5                  10                  15      
Val Asn Val Cys Gly Asn Pro Asn Met Thr Cys Pro Ser Asn Lys Thr
            20                  25                  30          


<210> 2666
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2666
Arg Ala Asn Ser Thr Ser Asp Glu Leu
 1               5                  


<210> 2667
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2667
Gln Pro Gln Ala Val Pro Pro Tyr Ala Ser Glu Asn Gln Thr Cys Arg
 1               5                  10                  15      
Asp
    


<210> 2668
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2668
Gln Pro Ala Asn Ser Asn Asn Gly Thr Ser Thr Ala Thr Ser Thr Asn
 1               5                  10                  15      
Asn Asn Ala Lys Arg
            20      


<210> 2669
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2669
Met Val Asn Asn Val Thr Pro Ala Arg Ala Val Val Ser Leu Ile Asn
 1               5                  10                  15      
Gly Gly Gln Arg Tyr
            20      


<210> 2670
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2670
Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn Ser Asn Thr Phe Leu
 1               5                  10                  15      
Thr Arg Leu
            


<210> 2671
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2671
Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His Leu Met
 1               5                  10                  15      
Lys Pro Asn Ala Val Pro Lys Ala Cys Cys Ala Pro Thr Lys Leu
            20                  25                  30      


<210> 2672
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2672
Met Leu Arg Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr
 1               5                  10                  15      
Pro Glu Ser Thr Thr Val Glu Pro Ala Ala Arg Arg Ser
            20                  25                  


<210> 2673
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2673
Met Gly Ile Ile Ala Val Ala Asn Asp Thr Asn Ser Cys Glu Leu Ser
 1               5                  10                  15      
Pro Cys Ala Leu Leu Asn Gly Gly Cys His Asp Leu Cys Leu Leu Thr
            20                  25                  30          
Pro Asn Gly Arg Val
        35          


<210> 2674
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2674
Met Gly His Asn Phe Ser Leu Pro Val Tyr Lys Gly Glu Ile Gln Ala
 1               5                  10                  15      
Arg Asn
        


<210> 2675
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2675
Met Phe Thr Met Ala Thr Ala Glu His Arg Ser Asn Ser Ser Ile Ala
 1               5                  10                  15      
Gly Lys Met
            


<210> 2676
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2676
Met Phe Met Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn
 1               5                  10                  15      
Phe Ser Ala Ala Phe Ser Val Asn Tyr Asp Thr Lys Ser
            20                  25                  


<210> 2677
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2677
Met Asp Thr Arg Asn Leu Ser Leu Ala His Asn Arg Ile
 1               5                  10              


<210> 2678
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2678
Leu Pro Pro Lys Ser Leu Ser Pro Glu Ser Glu Trp Leu Val Thr Phe
 1               5                  10                  15      
Ala Thr Thr Asn Ser Ser Gly Ile Ile Leu Ala Ala Leu Gly Gly Asp
            20                  25                  30          
Val Glu Lys Arg
        35      


<210> 2679
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2679
Leu Phe Gln Asn Ile Thr Leu Glu Asp Ala Gly Ser Tyr Thr Leu Arg
 1               5                  10                  15      
Thr
    


<210> 2680
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2680
Lys Tyr Gln Leu Leu His His Ser Ala Asn Gln Leu Ser Ile Thr Val
 1               5                  10                  15      
Pro Asn Val Thr Leu Gln Asp Glu Gly Val Tyr Lys Cys
            20                  25                  


<210> 2681
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2681
Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp Ile Asn Gly Thr
 1               5                  10                  15      
Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp
            20                  25          


<210> 2682
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2682
Lys Val Val Asn Leu Ser Ile His Met Val Leu Ile
 1               5                  10          


<210> 2683
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2683
Lys Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp
 1               5                  10                  15      
Gly
    


<210> 2684
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2684
Lys Val Asn Gly Thr Ile Thr Phe Ile Asp Glu Ile His Asn Asp Asp
 1               5                  10                  15      
Gly Val Trp Leu Arg Leu Asn Asp
            20                  


<210> 2685
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2685
Lys Val Leu Asn Gly Thr Leu Leu Met Ala Pro Ser Gly Cys Lys Ser
 1               5                  10                  15      


<210> 2686
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2686
Lys Val Lys Phe Gly Met Asn Val Thr Ser Ser Glu Lys Val
 1               5                  10                  


<210> 2687
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2687
Lys Thr Trp Asn Gln Ser Ile Ala Leu Arg Leu
 1               5                  10      


<210> 2688
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2688
Lys Thr Pro Ala Ser Asn Ile Ser Thr Gln Val Ser His Thr Lys Leu
 1               5                  10                  15      
Ser Val Glu Ala Pro Asp Ser Lys Phe
            20                  25  


<210> 2689
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2689
Lys Thr Asp Glu Lys Leu Asn Val Ser Asp Glu Asn Thr Ala Ser Cys
 1               5                  10                  15      
Pro Leu Ser Pro Ile Lys Met
            20              


<210> 2690
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2690
Lys Ser Gly Asn Tyr Thr Val Leu Gln Val Val Glu Ala Leu Gly Ser
 1               5                  10                  15      
Ser Leu Glu Asn Pro Glu Pro Arg Thr Arg Ala
            20                  25          


<210> 2691
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2691
Lys Ser Glu Met Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr
 1               5                  10                  15      
Ala Thr Met Leu Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu
            20                  25                  30          
Gln Thr Arg Lys Leu
        35          


<210> 2692
<211> 41
<212> PRT
<213> Homo sapiens

<400> 2692
Lys Ser Asp Ala Leu Val Pro Val Ser Gly Thr Ser Leu Ala Val Gly
 1               5                  10                  15      
Ile Asp Phe His Ala Glu Asn Asp Thr Ile Tyr Trp Val Asp Met Gly
            20                  25                  30          
Leu Ser Thr Ile Ser Arg Ala Lys Arg
        35                  40      


<210> 2693
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2693
Lys Asn Tyr Glu Asp Glu Pro Asn Asn Tyr Arg Thr Met His Gly Arg
 1               5                  10                  15      
Ala Val Asn Gly Ser Gln Leu Gly Lys Asp
            20                  25      


<210> 2694
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2694
Lys Asn Val Asn Gln Ser Leu Leu Glu Leu His Ala Leu Ala Ser Asp
 1               5                  10                  15      
Lys Gly
        


<210> 2695
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2695
Lys Asn Arg Asn Ser Ser Val Val Pro Ser Glu Arg Ala Arg Val Gly
 1               5                  10                  15      
Leu Ala
        


<210> 2696
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2696
Lys Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln
 1               5                  10                  15      
Glu Gly Thr Tyr Thr Cys
            20          


<210> 2697
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2697
Lys Asn Val Thr Glu Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro
 1               5                  10                  15      
Val Leu Phe Ser Ser Asp Phe Arg Ile Ser
            20                  25      


<210> 2698
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2698
Lys Asn Val Ser Glu Ile Ile Ala Thr Ile Met Glu Thr Leu Lys Met
 1               5                  10                  15      
Lys
    


<210> 2699
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2699
Lys Asn Ile Thr Leu Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr Val
 1               5                  10                  15      
Thr Pro Ser Gly Gln
            20      


<210> 2700
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2700
Lys Asn Cys Thr Asn Asn Cys Thr Phe Val Tyr Ala Ala Glu Gln Pro
 1               5                  10                  15      
Pro Glu Ala Pro Gly Lys Ile
            20              


<210> 2701
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2701
Lys Met Asp Phe Leu Leu Phe Asn Tyr Ser Ala Pro Ser Tyr Leu Arg
 1               5                  10                  15      
Leu Leu
        


<210> 2702
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2702
Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu Ser Ala
 1               5                  10                  15      
Lys Gln Arg Leu
            20  


<210> 2703
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2703
Lys Leu Ala Asn Asn Gly Thr Val Leu Arg Ala
 1               5                  10      


<210> 2704
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2704
Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu
 1               5                  10  


<210> 2705
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2705
Lys Ile Ser Asp Asn Asn Thr Glu Phe Leu Leu Asn Phe Asn Glu Phe
 1               5                  10                  15      
Ile Asp Arg Lys
            20  


<210> 2706
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2706
Lys Ile Asn Pro Lys Asn Tyr Thr Glu Asn Glu Leu Glu Lys Ile Thr
 1               5                  10                  15      
Arg Arg
        


<210> 2707
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2707
Lys Ile Asn Cys Ile Arg Pro Asp Ala Phe Gln Asp Leu Gln Asn Leu
 1               5                  10                  15      
Ser Leu Leu Ser Leu Tyr Asp Asn Lys Ile
            20                  25      


<210> 2708
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2708
Lys Ile Lys Gly Ile Val Glu Asn Met Gly Ile Asn Ala Asn Asn Met
 1               5                  10                  15      
Ser Asp Phe Ile Met Lys Val Asp Ala Leu Met Ser Ser Val Pro Lys
            20                  25                  30          
Arg
    


<210> 2709
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2709
Lys His Ser Ala Gly Ser Gly Ala Glu Glu Ser Asn Ser Ser Ser Thr
 1               5                  10                  15      
Val Gln Lys Gln
            20  


<210> 2710
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2710
Lys Gly Arg Met Ser Thr Leu Thr Phe Phe Asn Val Ser Glu Lys Asp
 1               5                  10                  15      


<210> 2711
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2711
Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly Thr Pro Gly Gln Thr
 1               5                  10                  15      
Gly Ala Arg Gly
            20  


<210> 2712
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2712
Lys Gly Glu Gly Leu Asn Lys Thr Val Ile Gly Asp Tyr Leu Gly Glu
 1               5                  10                  15      
Arg Asp Glu Phe Asn Ile Lys Val
            20                  


<210> 2713
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2713
Lys Phe Val Leu Asn Ser Asn Ile Thr Asn Ile Pro Gln
 1               5                  10              


<210> 2714
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2714
Lys Glu Met Thr Asn Glu Glu Lys Asn Ile Ile Thr Asn Leu Ser Lys
 1               5                  10                  15      
Cys
    


<210> 2715
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2715
Lys Glu Glu Asn Leu Ser Met His Gln Met Leu Asp Gln Thr Leu Leu
 1               5                  10                  15      
Glu Leu Asn Asn Met
            20      


<210> 2716
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2716
Lys Asp Arg Cys Asn Val Glu Lys Val Pro Ser Asn Ser Gln Leu Glu
 1               5                  10                  15      
Ile Glu Gly Asn Ser Ser Gly Arg Gln
            20                  25  


<210> 2717
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2717
Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe Ala Thr Ile Pro
 1               5                  10                  15      
Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg
            20                  25      


<210> 2718
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2718
Lys Asp Gly Ser Asn Lys Ser Gly Ala Glu Glu Gln Gly Pro Ile Asp
 1               5                  10                  15      
Gly Pro Ser Lys Ser Gly Ala Glu Glu Gln Thr Ser Lys Asp
            20                  25                  30  


<210> 2719
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2719
Lys Cys Thr Leu His Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser
 1               5                  10                  15      
Tyr Ile Cys Arg Pro Lys Met Ile Lys Ser
            20                  25      


<210> 2720
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2720
Lys Cys Pro Lys Pro Met Glu Glu Asn His Ser Val Ser His Lys Lys
 1               5                  10                  15      
Ser Lys Lys Lys
            20  


<210> 2721
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2721
Lys Ala Met Ala Glu Thr Phe Tyr Leu Ser Asn Ile Val Pro Gln Asp
 1               5                  10                  15      
Phe Asp Asn Asn Ser Gly Tyr Trp Asn Arg Ile
            20                  25          


<210> 2722
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2722
Lys Ala Leu Trp Asn Leu Arg Ser Asn Asp Thr Gly Leu Leu Gly Asn
 1               5                  10                  15      
Val Val Asn Ile Gln Thr Gly His Trp Val Gly Lys Gln
            20                  25                  


<210> 2723
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2723
Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser Asn Gly Ser Asn
 1               5                  10                  15      
Ser
    


<210> 2724
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2724
Lys Ala Phe His Thr Glu Ile Ser Ser Ser Asp Asn Asn Thr Leu Thr
 1               5                  10                  15      
Ser Ser Asn Ala Tyr Asn Ser Arg Tyr
            20                  25  


<210> 2725
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2725
Ile Val Leu Asn Asn Leu Ser Val Asn Ala Glu Asn Gln
 1               5                  10              


<210> 2726
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2726
Ile Thr Asn Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu
 1               5                  10                  15      
Met Asn Pro Glu Gly Arg Lys Glu
            20                  


<210> 2727
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2727
Ile Asn Ser Thr Leu Lys Gly Arg Trp Arg Val
 1               5                  10      


<210> 2728
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2728
Ile Ile Ala Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr His
 1               5                  10                  15      
Gly Asn Leu Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln
            20                  25                  


<210> 2729
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2729
Ile Phe Asn Glu Thr Lys Asn Pro Thr Leu Thr Arg Arg
 1               5                  10              


<210> 2730
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2730
Gly Arg Val Pro Val Asn Val Thr Ser Thr Ala Leu Leu Ser Val Leu
 1               5                  10                  15      
Asp Ile Phe Pro Thr Val Val Ala Leu Ala Gln Ala Ser Leu Pro Gln
            20                  25                  30          
Gly Arg Arg
        35  


<210> 2731
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2731
Gly Lys Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp
 1               5                  10              


<210> 2732
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2732
Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn Ser Asn Ser
 1               5                  10                  15      
Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys Gly
            20                  25                  


<210> 2733
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2733
Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val Cys
 1               5                  10                  15      
Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp
            20                  25          


<210> 2734
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2734
Phe Gly Asn Phe Gln Gly Leu Met Glu Ala Asn Val Ser Leu Asp Leu
 1               5                  10                  15      
Gly Lys Leu
            


<210> 2735
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2735
Phe Glu Asn Lys Thr Asn Leu Lys Asn Gln Leu Ile Leu Gly Val Met
 1               5                  10                  15      
Gly Val Asp Val Ser Leu Glu Asp Ile Lys Arg Leu
            20                  25              


<210> 2736
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2736
Phe Glu Ala Phe Gln Asp Ala Leu Asn Gln Glu Thr Thr Tyr Val Ser
 1               5                  10                  15      
Asn Leu Thr Arg Ser
            20      


<210> 2737
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2737
Asp Asn Thr Leu Gln Gln Asn Ser Ser Ser Asn Ile Ser Tyr Ser Asn
 1               5                  10                  15      
Ala Met Gln Lys Glu
            20      


<210> 2738
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2738
Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met Asn Pro
 1               5                  10                  15      
Met Leu Leu Leu Thr Gly Arg Thr
            20                  


<210> 2739
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2739
Arg Val Lys Asn Ile Ser Asp Ala Asp Val His Asn Ala Met Asp Asn
 1               5                  10                  15      
Tyr Glu Cys
            


<210> 2740
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2740
Arg Val Gly Gly Phe Gly Phe Val Ala Thr Pro Ser Pro Ala Pro Gly
 1               5                  10                  15      
Val Asn Glu Ser Pro Met Met Thr Trp Gly Glu Val Glu Asn Thr Pro
            20                  25                  30          
Leu Arg Val
        35  


<210> 2741
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2741
Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg
 1               5                  10                  15      
Thr Arg Lys Arg Arg
            20      


<210> 2742
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2742
Arg Arg Arg Arg Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His
 1               5                  10                  15      


<210> 2743
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2743
Arg Asn Thr Gly Asn Gly Thr Gln Ser Ser Met Gly Ser Pro Leu Thr
 1               5                  10                  15      
Arg Pro
        


<210> 2744
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2744
Arg Asn Phe Asp Lys Asn Gly Asn Met Met Asp Trp Trp Ser Asn Phe
 1               5                  10                  15      
Ser Thr Gln His Phe Arg Glu
            20              


<210> 2745
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2745
Arg Asn Gly Ser Leu Gln Glu Lys Leu Trp Ala Ile Leu Gln Ala Thr
 1               5                  10                  15      
Tyr Ile His Ser Trp Asn Leu Ala Arg Phe Val Phe Thr Tyr Lys Gly
            20                  25                  30          


<210> 2746
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2746
Arg Asn Cys Ser His Trp Ala Val Gly Val Ala Ser Trp Glu Met Ser
 1               5                  10                  15      
Arg
    


<210> 2747
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2747
Arg Ile Arg Asn Ile Ser Asn Thr Val Met Lys Val Lys Gln Ile Leu
 1               5                  10                  15      
Gly Arg Ser
            


<210> 2748
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2748
Arg His Val Leu Ala Thr Ile Leu Ala Gln Leu Ser Asp Met Asp Leu
 1               5                  10                  15      
Ile Asn Val Ser Lys Val
            20          


<210> 2749
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2749
Arg Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Tyr Asn
 1               5                  10                  15      
Arg Ser
        


<210> 2750
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2750
Arg Gly Gly Asn Asn Ser Phe Thr His Glu Ala Leu Thr Leu Lys Tyr
 1               5                  10                  15      


<210> 2751
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2751
Arg Gly Glu Asn Val Ser Thr Thr Glu Val Glu Gly Val Leu Ser Arg
 1               5                  10                  15      
Leu Leu Gly Gln Thr Asp Val Ala Val Tyr Gly Val Ala Val Pro Gly
            20                  25                  30          
Lys Leu
        


<210> 2752
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2752
Arg Gly Cys Ala Ser Thr Gly Val Ile Met Ser Val Asn Asn Ser Leu
 1               5                  10                  15      
Tyr Leu Gly Pro Ile Leu Lys Phe Gly Ser Lys Glu
            20                  25              


<210> 2753
<211> 8
<212> PRT
<213> Homo sapiens

<400> 2753
Arg Phe Leu Leu Tyr Asn Arg Ser
 1               5              


<210> 2754
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2754
Arg Glu Thr Gln Ala Ile Asn Ser Ser Leu Ser Thr Leu Gly Leu Val
 1               5                  10                  15      
Ile Met Ala Leu Ser Asn Lys Glu
            20                  


<210> 2755
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2755
Pro Arg Met Ser Val Leu Arg Ser Ala Glu Thr Met Gln Ser Ala Leu
 1               5                  10                  15      
Ala Ala Met Gln Gln Phe Tyr Gly Ile Asn Met Thr Gly Lys Val
            20                  25                  30      


<210> 2756
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2756
Pro Pro Thr Leu Val Pro Leu Met Asn Gly Ser Ala Thr Pro Leu Pro
 1               5                  10                  15      
Thr Ala Leu Gly Leu Gly Gly Arg Ala
            20                  25  


<210> 2757
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2757
Pro Asn His Arg Pro Thr Gly Arg Gly Asn Asn Ile Ser Ser His His
 1               5                  10                  15      


<210> 2758
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2758
Asn Leu Thr Gln Asn Leu Met Gln Asn Leu Thr Gln Ser Leu Ser Gln
 1               5                  10                  15      
Lys Glu Asn Arg Glu
            20      


<210> 2759
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2759
Met Val Asp Lys Tyr Ile Pro Asn Ile Ser Met Cys Leu Lys Asp Ser
 1               5                  10                  15      
Asp Pro Phe Ile Arg Lys
            20          


<210> 2760
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2760
Met Thr Ala Met Asp Asn Ala Ser Lys Asn Ala Ser Glu Met Ile Asp
 1               5                  10                  15      
Lys Leu Thr Leu Thr Phe Asn Arg Thr
            20                  25  


<210> 2761
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2761
Met Gly Ile Asn Glu Cys Gln Tyr Gln Phe Arg Phe Gly Arg Trp Asn
 1               5                  10                  15      
Cys Ser Ala Leu Gly Glu Lys Thr
            20                  


<210> 2762
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2762
Met Asp Arg Trp Asn Glu Thr Val Gly Leu Glu Trp Glu Leu Glu Arg
 1               5                  10                  15      
Gln Leu Ala Leu Met Asn Ser Gln Phe Asn Arg Arg Val
            20                  25                  


<210> 2763
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2763
Met Ala Leu Val Leu Ser Asn Phe Ser Thr Leu Thr Leu Leu Leu Gly
 1               5                  10                  15      
Gln Arg Phe
            


<210> 2764
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2764
Lys Trp Tyr Leu Glu Asn Val Tyr Pro Glu Met Arg Val Tyr Asn Asn
 1               5                  10                  15      
Thr Leu Thr Tyr Gly Glu Val Arg Asn Ser Lys Ala
            20                  25              


<210> 2765
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2765
Lys Ser Tyr Arg Asn Ser Ser Tyr Glu Asn Ala Arg Glu Asn Ser Gln
 1               5                  10                  15      
Met Asn Glu Ser Ala Pro Gly Thr Tyr Val Val Gln Asn Pro His Ser
            20                  25                  30          


<210> 2766
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2766
Lys Ser Val Asn Lys Met Gln Glu Ala Thr Pro Ser Ala Gln Ala Thr
 1               5                  10                  15      
Asn Glu Thr Gln Met Cys Tyr Ala Ser Leu Asp His Ser Val Lys Gly
            20                  25                  30          


<210> 2767
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2767
Lys Asn Asn Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn Ser
 1               5                  10                  15      
Lys Val Glu Arg Ser Gln
            20          


<210> 2768
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2768
Lys Leu Leu Lys Ser Ile Pro Leu Asp Val Val Leu Ser Asn Asn Asn
 1               5                  10                  15      
His Thr Glu Ile Gln Glu Ile Ser Leu Ala Leu Arg Ser
            20                  25                  


<210> 2769
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2769
Lys Leu Leu Glu Glu Asn Glu Thr Glu Ala Val Thr Val Pro Thr Pro
 1               5                  10                  15      
Ser Pro Thr
            


<210> 2770
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2770
Lys Lys Leu Asn Cys Ser Pro Asp Ser Phe Arg Cys
 1               5                  10          


<210> 2771
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2771
Lys Lys His Glu Leu Lys Pro Asn Asn Pro Thr Glu Glu Gly Leu Ala
 1               5                  10                  15      
Ser Ile His Ser Val Leu Phe Arg Lys Asp Pro Phe
            20                  25              


<210> 2772
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2772
Lys Lys Glu Asn Val Ala Ala Asp Ile Pro Ile Thr Glu Thr Glu Ala
 1               5                  10                  15      
Tyr Gln Leu Leu Lys Lys Ala Thr Leu Gln Asp Asn Thr Asn Gln Thr
            20                  25                  30          
Glu Asn Arg
        35  


<210> 2773
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2773
Lys Ile Asn Phe Glu Asn Ala Asn Leu Ser Ala Leu Asn Leu Lys Ile
 1               5                  10                  15      


<210> 2774
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2774
Lys His Glu Leu Gly Ile Thr Ala Val Met Asn Phe Gln Thr Glu Trp
 1               5                  10                  15      
Asp Ile Val Gln Asn Ser Ser Gly Cys Asn Arg Tyr
            20                  25              


<210> 2775
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2775
Lys Gly Thr Val Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr Ala
 1               5                  10                  15      
Met Leu Met Ala Ala Ser Val Ala Arg Lys
            20                  25      


<210> 2776
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2776
Lys Glu Gln Gln Pro Asn Asp Leu Leu Ser Val Gln Phe Ile Asp Tyr
 1               5                  10                  15      
Gly Asn Val Ser Val Val His Thr Asn Lys Ile
            20                  25          


<210> 2777
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2777
Lys Asp Phe Leu Asp Val Tyr Tyr Asn Leu Thr Leu Lys Thr Met Met
 1               5                  10                  15      
Gly Ile Glu Trp Val
            20      


<210> 2778
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2778
Phe Ser Tyr Pro Asn Gly Leu Ser Glu Asn Thr Ser Val Val Glu Lys
 1               5                  10                  15      
Leu Lys His
            


<210> 2779
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2779
Met Asp Pro Asn Cys Ser Cys Ala Ala Ala Gly Val Ser Cys Thr Cys
 1               5                  10                  15      
Ala Ser Ser Cys Lys Cys
            20          


<210> 2780
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2780
Tyr Val Asn Glu Thr Leu Ala Asn Arg Thr
 1               5                  10  


<210> 2781
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2781
Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro Gln Asn Ala
 1               5                  10                  15      
Ser Leu Ile Ala His Leu Ala Arg Thr
            20                  25  


<210> 2782
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2782
Tyr Cys Gly Thr Trp Asn Asn Ser Leu Ser Gly Trp Val Phe Gly Gly
 1               5                  10                  15      
Gly Thr Lys Leu
            20  


<210> 2783
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2783
Trp Gly Lys Glu Leu Ile Glu Thr Leu Trp Asn Leu Gly Asp His Glu
 1               5                  10                  15      
Leu Leu His Met Tyr Pro Gly Asn Val Ser Lys Leu
            20                  25              


<210> 2784
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2784
Val Tyr Tyr Met Val Val Cys Leu Val Ala Phe Thr Ile Val Met Val
 1               5                  10                  15      
Leu Asn Ile Thr Arg Leu
            20          


<210> 2785
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2785
Val Asn Leu Thr Gly Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val
 1               5                  10                  15      
Thr Asn Ile Asn Val Lys Lys Met
            20                  


<210> 2786
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2786
Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly
 1               5                  10                  15      
Asn Val Thr Glu Ser Gly Cys Lys Glu
            20                  25  


<210> 2787
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2787
Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala Asp Gly Phe Ser Ser
 1               5                  10                  15      
Arg Val
        


<210> 2788
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2788
Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr
 1               5                  10                  15      
His Gly His Arg Gly
            20      


<210> 2789
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2789
Thr Thr Asp Phe Cys Ser Val Ser Thr Ala Thr Pro Val Pro Thr Ala
 1               5                  10                  15      
Asn Ser Thr Ala Lys Pro Thr Val Gln Pro Ser Pro Ser Thr Thr Ser
            20                  25                  30          
Lys Thr
        


<210> 2790
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2790
Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His Ser Pro
 1               5                  10                  15      
Ile Thr Met Tyr Val Ile Gln Ala Arg Thr
            20                  25      


<210> 2791
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2791
Ser Val Thr Gly Asn Pro Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro
 1               5                  10                  15      
Ser Ser Glu Thr Gly Asn Pro Arg His
            20                  25  


<210> 2792
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2792
Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser
 1               5                  10              


<210> 2793
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2793
Ser Leu Lys Asp Asn Ser Ser Cys Ser Val Met Ser Glu Glu Pro Glu
 1               5                  10                  15      
Gly Arg Ser
            


<210> 2794
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2794
Arg Tyr Val His Asp Gly Ser Glu Thr Leu Thr Asp Ser Phe Val Leu
 1               5                  10                  15      
Met Ala Asn Ala Ser Glu Met Asp Arg Gln
            20                  25      


<210> 2795
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2795
Arg Tyr Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro
 1               5                  10                  15      
Ala Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu
            20                  25              


<210> 2796
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2796
Arg Tyr Ser Trp Gln Cys Val Asn Gln Ser Val Leu Cys Gly Pro Ser
 1               5                  10                  15      
Gly Asn His Thr Asp Ile Glu Thr Lys Gln
            20                  25      


<210> 2797
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2797
Arg Tyr Leu Ser Leu Arg Asn Asn Ser Leu Arg Thr
 1               5                  10          


<210> 2798
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2798
Arg Tyr Leu Gln Ile Asn Asn Ala Asp Leu Gly Asp Thr Ala Asn Tyr
 1               5                  10                  15      
Thr Cys Val Ala Ser Asn Ile Ala Gly Lys Thr
            20                  25          


<210> 2799
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2799
Arg Tyr Asp Phe Asp Leu Phe Ala Asn Glu Ser Val Pro Asp His Val
 1               5                  10                  15      
Gly Tyr Ala Lys Val
            20      


<210> 2800
<211> 9
<212> PRT
<213> Homo sapiens

<400> 2800
Arg Trp Asn Thr Thr Tyr Arg Arg Tyr
 1               5                  


<210> 2801
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2801
Arg Val Gln Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln
 1               5                  10                  15      
Tyr Ser Leu Ser Asn Ser Thr Gln Ala Glu Leu Arg His
            20                  25                  


<210> 2802
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2802
Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly Ile Ser
 1               5                  10                  15      
Val Leu Asn Pro Asn Lys Thr
            20              


<210> 2803
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2803
Arg Val Leu Asp Ile Asn Asp Asn Asp Pro Val Leu Leu Asn Leu Pro
 1               5                  10                  15      
Met Asn Ile Thr Ile
            20      


<210> 2804
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2804
Arg Val Lys Val Gln Asp Leu Val Leu Glu Pro Thr Gln Asn Ile Thr
 1               5                  10                  15      
Thr Lys Gly Val Ser Val Arg Arg Lys Arg Gln
            20                  25          


<210> 2805
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2805
Arg Val Phe Ser Asn Val Ser Ile Ile Leu Phe Leu Asn Lys Thr
 1               5                  10                  15  


<210> 2806
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2806
Arg Thr Ser His Gly Glu Pro Lys Ser Ala Val Pro Phe Asn Gln Tyr
 1               5                  10                  15      
Leu Pro Asn Lys Ser Asn Gln Thr Ala Tyr Val Pro Ala Pro Leu Arg
            20                  25                  30          
Lys Lys
        


<210> 2807
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2807
Arg Thr Arg Ser Thr Ser Ser Ala Gly Ser Asn Asn Ser Ala Glu Gly
 1               5                  10                  15      
Ala Gly Leu Thr Asp Asn Gly Cys Arg Arg
            20                  25      


<210> 2808
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2808
Arg Thr Leu Pro Leu Ile Leu Ile Leu Leu Ala Leu Leu Ser Pro Gly
 1               5                  10                  15      
Ala Ala Asp Phe Asn Ile Ser Ser Leu Ser Gly Leu Leu Ser Pro Ala
            20                  25                  30          
Leu Thr Glu
        35  


<210> 2809
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2809
Arg Ser Thr Asn His Ser Thr Gln Ser Ala Leu Asn Gln Ser Leu His
 1               5                  10                  15      
Thr Val Gly Ala Gln Pro Ile Thr Ala His Ser Arg Arg
            20                  25                  


<210> 2810
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2810
Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg
 1               5                  10                  15      
Phe
    


<210> 2811
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2811
Arg Ser Ser Asn Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys
 1               5                  10                  15      
Pro
    


<210> 2812
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2812
Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro Pro Leu Glu Gln Cys
 1               5                  10                  15      
Val Pro Asp Arg Gly
            20      


<210> 2813
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2813
Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln Ile Asn Arg Thr
 1               5                  10                  15      


<210> 2814
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2814
Arg Arg Gln Arg Arg Met His Pro Asn Val Ser Gln Gly Cys Gln Gly
 1               5                  10                  15      
Gly Cys Ala Thr Cys Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro
            20                  25                  30          


<210> 2815
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2815
Arg Arg Gln Ile Ser Gln Lys Ala Phe Leu Phe Asn Ser Ser Glu Gln
 1               5                  10                  15      
Val Ala Glu Phe Val Ile Ser Arg Pro
            20                  25  


<210> 2816
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2816
Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro Ser Thr
 1               5                  10                  15      
Ala Gly Phe Leu Val Ala Trp Pro Met
            20                  25  


<210> 2817
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2817
Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr Tyr Glu Ile Val
 1               5                  10                  15      
Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys Lys
            20                  25                  


<210> 2818
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2818
Arg Gln Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp Pro Glu
 1               5                  10                  15      
Pro Gly Gly Leu Leu Thr Ser Gln Gly Phe Ile
            20                  25          


<210> 2819
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2819
Arg Gln Leu Gly Asn Gly Ser Leu Ala Ile Tyr Gly Thr Val Asn Glu
 1               5                  10                  15      
Asp Ala Gly Asp Tyr Thr Cys Val
            20                  


<210> 2820
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2820
Arg Gln Gly Gly Val Asn Ala Thr Gln Val Leu Ile Gln His Leu Arg
 1               5                  10                  15      
Gly
    


<210> 2821
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2821
Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys
 1               5                  10                  15      
Glu Thr Gln Lys Lys
            20      


<210> 2822
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2822
Arg Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr
 1               5                  10                  15      
His Asn Gln Glu Lys Lys
            20          


<210> 2823
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2823
Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr Leu Pro
 1               5                  10                  15      
Val Leu Glu Gly Gln Ala Leu Arg Leu
            20                  25  


<210> 2824
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2824
Arg Asn Phe Asp Asn Ser Ser Gln Asn Thr Thr Ala Ser Val Ser Ser
 1               5                  10                  15      
Lys Gly Pro Met Ile Leu Leu Gln Ala Thr Lys
            20                  25          


<210> 2825
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2825
Arg Asn Thr Thr Ser Thr Cys Ile Ala Thr Val Val Gly Leu Thr Gly
 1               5                  10                  15      
Ala Arg Leu
            


<210> 2826
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2826
Arg Asn Thr Thr Leu Phe Ile Asp Gln Val Glu Ala Lys Trp
 1               5                  10                  


<210> 2827
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2827
Arg Asn Ser Ser Leu Gly Asp Ala Ile Asn Lys Tyr Asp Val Val Ile
 1               5                  10                  15      
Arg Leu Asn Asn Ala Pro Val Ala Gly Tyr
            20                  25      


<210> 2828
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2828
Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile
 1               5                  10          


<210> 2829
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2829
Arg Asn Leu Ser Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys Arg
 1               5                  10                  15  


<210> 2830
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2830
Arg Asn Phe Ser Ser Val Ala Ala Ser Ser Gly Asn Thr Thr Leu Asn
 1               5                  10                  15      


<210> 2831
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2831
Arg Met Leu Trp Glu His Asn Ser Thr Ile Ile Val Met Leu Thr Lys
 1               5                  10                  15      
Leu
    


<210> 2832
<211> 42
<212> PRT
<213> Homo sapiens

<400> 2832
Arg Leu Val Arg Val Thr Tyr Val Ser Ser Glu Gly Gly His Ser Gly
 1               5                  10                  15      
Gln Thr Glu Ala Pro Gly Asn Ala Thr Ser Ala Met Leu Gly Pro Leu
            20                  25                  30          
Ser Ser Ser Thr Thr Tyr Thr Val Arg Val
        35                  40          


<210> 2833
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2833
Arg Leu Gln Asn Ser Gln Cys Tyr Asn Trp Thr Leu Leu Leu Gly Asn
 1               5                  10                  15      
Arg Trp
        


<210> 2834
<211> 41
<212> PRT
<213> Homo sapiens

<400> 2834
Arg Leu Leu Leu Thr Ala Ala His Leu Leu Phe Val Ala Pro His Asn
 1               5                  10                  15      
Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser Ser Gly Ser Gly Pro Pro
            20                  25                  30          
Ser Gly Gly Ala Leu Gly Pro Arg Ala
        35                  40      


<210> 2835
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2835
Arg Leu Phe Pro Asn Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr
 1               5                  10                  15      
Ala Pro Asn Pro Asp Lys His
            20              


<210> 2836
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2836
Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr
 1               5                  10                  15      
Phe Met Leu Ala
            20  


<210> 2837
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2837
Arg Lys Leu Tyr Lys Cys Pro Ala Cys Gly Glu Thr Leu Gln Asp Ser
 1               5                  10                  15      
Thr Gly Asn Phe Ser Ser Pro Glu Tyr Pro Asn Gly Tyr Ser Ala His
            20                  25                  30          
Met His
        


<210> 2838
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2838
Arg Lys Phe Ala Met Ser Pro Ser Asn Phe Ser Ser Ser Asp Cys Gln
 1               5                  10                  15      
Asp Glu Glu Gly Arg Lys
            20          


<210> 2839
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2839
Arg Lys Ala Leu Pro Met Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly
 1               5                  10                  15      
Glu His Gly Ile Val Val Phe Ser Leu Gly Ser Met Val Ser Glu
            20                  25                  30      


<210> 2840
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2840
Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 2841
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2841
Arg Ile Thr Val His Gly Asn Gly Ser Leu Asp Ile Arg Ser Leu Arg
 1               5                  10                  15      
Lys Ser
        


<210> 2842
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2842
Arg Ile Gln Leu Glu Asn Val Thr Leu Leu Asn Pro Asp Pro Ala Glu
 1               5                  10                  15      
Gly Pro Lys Pro Arg Pro
            20          


<210> 2843
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2843
Arg Ile Pro Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly
 1               5                  10                  15      
Ala Pro Pro Gly Ala Ala Val Gln Ala Arg Ser
            20                  25          


<210> 2844
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2844
Arg His Ser Ser Thr Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser
 1               5                  10                  15      
Pro Tyr Asp Asn Asn Ser Pro Val Leu Ser Glu Arg Ser
            20                  25                  


<210> 2845
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2845
Arg His Asn Asn Ile Thr Ser Ile Ser Thr Gly Ser Phe Ser Thr Thr
 1               5                  10                  15      
Pro Asn Leu Lys Cys
            20      


<210> 2846
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2846
Arg His Leu Thr Leu Ile Asp Leu Ser Asn Asn Ser Ile Ser Met Leu
 1               5                  10                  15      
Thr Asn Tyr Thr Phe Ser Asn Met Ser His
            20                  25      


<210> 2847
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2847
Arg Gly Val Asn Ala Ser Ala Val Val Asn Val Thr Val Arg Ala Leu
 1               5                  10                  15      
Leu His Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu Arg
            20                  25                  30          
Leu
    


<210> 2848
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2848
Arg Gly Val His Asn Ala Ser Leu Ala Leu Ser Ala Ser Ile Gly Arg
 1               5                  10                  15      
Val Arg Glu
            


<210> 2849
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2849
Arg Gly Thr Arg Ala Arg Leu Leu Ser Ser Phe Leu Ser Phe Leu Asn
 1               5                  10                  15      
Gly Ser Ser Ala Asn Gln Ala Val Gly Gln Gly Pro Glu Ala Gly Glu
            20                  25                  30          
Gly Arg Gly
        35  


<210> 2850
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2850
Arg Gly Ser Val Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile Ala
 1               5                  10                  15      
Phe Leu Asn Ala Thr Ile Thr Asp Ser Pro Asn Ser
            20                  25              


<210> 2851
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2851
Arg Gly Ser Ser Asn Pro Leu Leu Thr Thr Glu Glu Ala Asn Leu Thr
 1               5                  10                  15      
Glu Lys Glu
            


<210> 2852
<211> 41
<212> PRT
<213> Homo sapiens

<400> 2852
Arg Gly Ser His Ala Gly Asn Leu Thr Val Ala Val Val Leu Pro Leu
 1               5                  10                  15      
Ala Asn Thr Ser Tyr Pro Trp Ser Trp Ala Arg Val Gly Pro Ala Val
            20                  25                  30          
Glu Leu Ala Leu Ala Gln Val Lys Ala
        35                  40      


<210> 2853
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2853
Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro Asp Ser Gly Asn
 1               5                  10                  15      
Leu Thr Val Ala Arg Ser
            20          


<210> 2854
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2854
Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala Val Pro Val Phe Tyr
 1               5                  10                  15      
Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys Ser Gly Val Val Asn
            20                  25                  30          
Arg Asn
        


<210> 2855
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2855
Arg Phe Ala Arg His Pro Phe Tyr Gly Ser Ala Gly Val Asn Ser Gly
 1               5                  10                  15      
Val Met Leu Met Asn Leu Thr Arg Ile
            20                  25  


<210> 2856
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2856
Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp
 1               5                  10                  15  


<210> 2857
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2857
Arg Glu Gln Glu Cys Glu Ile Ile Ser Phe Ala Glu Thr Gly Leu Ser
 1               5                  10                  15      
Thr Ile Asn Gln Thr Arg Leu
            20              


<210> 2858
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2858
Arg Glu Cys Thr Cys Pro Pro Gly Met Phe Gln Ser Asn Ala Thr Cys
 1               5                  10                  15      
Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly
            20                  25                  30          


<210> 2859
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2859
Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser Val Thr Val Val
 1               5                  10                  15      
Ala Leu Leu Gln Ala Ser Cys Tyr Leu
            20                  25  


<210> 2860
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2860
Arg Asp His Gly Ser Pro Thr Leu Ser Ala Asn Val Ser Leu Arg Val
 1               5                  10                  15      
Leu Val Gly Asp Arg Asn Asp Asn Ala Pro Arg Val
            20                  25              


<210> 2861
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2861
Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val Gly
 1               5                  10                  15      
Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly
            20                  25              


<210> 2862
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2862
Arg Asp Asp Ala Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe
 1               5                  10                  15      
Val Leu Asp Arg Ile
            20      


<210> 2863
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2863
Arg Cys Asn Ile Ser Leu Pro Met Glu Asn Gly Leu Asn Ser Ile Glu
 1               5                  10                  15      
Trp Arg Leu
            


<210> 2864
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2864
Arg Cys Ile Pro Gln Ser Trp Val Cys Asp Gly Asp Val Asp Cys Thr
 1               5                  10                  15      
Asp Gly Tyr Asp Glu Asn Gln Asn Cys Thr Arg Arg Thr
            20                  25                  


<210> 2865
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2865
Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg Ser
 1               5                  10                  15      
Leu Pro Gly Leu Ile Gly Cys His Arg Lys
            20                  25      


<210> 2866
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2866
Arg Ala Trp His Asn Leu Thr Val Leu Ala Thr Glu Leu Asp Ser Ser
 1               5                  10                  15      
Ala Gln Ala Ser Arg Val
            20          


<210> 2867
<211> 38
<212> PRT
<213> Homo sapiens

<400> 2867
Arg Ala Ser Val Val Trp Met Ala Tyr Met Asn Ile Ser Phe His Val
 1               5                  10                  15      
Gly Asn His Val Leu Ser Glu Leu Gly Glu Thr Gly Val Phe Gly Arg
            20                  25                  30          
Ser Ser Thr Leu Lys Arg
        35              


<210> 2868
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2868
Arg Ala Leu Lys Gly Glu Thr Val Asn Thr Thr Ile Ser Phe Ser Phe
 1               5                  10                  15      
Lys Gly Ile Lys Phe Ser Lys Gly Lys Tyr
            20                  25      


<210> 2869
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2869
Arg Ala Lys Trp Asp Thr Ala Asn Asn Pro Leu Tyr Lys Glu Ala Thr
 1               5                  10                  15      
Ser Thr Phe Thr Asn Ile Thr Tyr Arg Gly
            20                  25      


<210> 2870
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2870
Arg Ala Ala Thr Ala Pro Leu Leu Glu Ala Val Asp Asn Leu Ser Ala
 1               5                  10                  15      


<210> 2871
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2871
Gln His Ser Leu Asn Leu Thr Glu Ser Thr Ser Leu Asp Met Leu Leu
 1               5                  10                  15      
Asp Asp Thr Gly Glu Cys Ser Ala Arg Lys
            20                  25      


<210> 2872
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2872
Pro Ser Leu Leu Leu Phe Ile Asn Ser Ser Ser Gln Asp Phe Val Val
 1               5                  10                  15      
Val Leu Leu Cys Lys Asn
            20          


<210> 2873
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2873
Pro Leu Leu Pro Lys Ser Ser Thr Ile Glu Glu Glu Glu Asn Met Ser
 1               5                  10                  15      
Gly His Lys Cys
            20  


<210> 2874
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2874
Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu
 1               5                  10                  15      
Glu Leu Thr Phe Arg Leu
            20          


<210> 2875
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2875
Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser Arg
 1               5                  10                  15      
Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala
            20                  25      


<210> 2876
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2876
Asn Pro Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser
 1               5                  10                  15      
Ile Leu Lys Leu
            20  


<210> 2877
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2877
Asn Ile Ser Arg Leu Asp Pro Gln Thr Asn Ser Ser Gln Ile Lys Asp
 1               5                  10                  15      
Glu Phe Gln Thr Leu Asn Ile Val Thr Pro Arg Val
            20                  25              


<210> 2878
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2878
Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro Glu Asp
 1               5                  10                  15      
Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln
            20                  25                  


<210> 2879
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2879
Met Val Ser Phe Val Ser Asn Tyr Ser His Thr Ala Asn Ile Leu Pro
 1               5                  10                  15      
Asp Ile Glu Asn Glu Asp Phe Ile Lys Asp Cys Val Arg Ile His Asn
            20                  25                  30          
Lys Phe Arg Ser
        35      


<210> 2880
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2880
Met Val His Met Pro Asp Ser Leu Gly Gly Gly Pro Glu Gly Pro Cys
 1               5                  10                  15      
Phe Cys Pro Thr Pro Cys Asn Leu Thr Arg Tyr
            20                  25          


<210> 2881
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2881
Met Thr Leu Ser Ile Thr Ser Gly Met Pro Asn Asn Phe Ser Glu Met
 1               5                  10                  15      
Pro Gln Gln Ser Thr Thr Leu Asn Leu Trp Arg Glu
            20                  25              


<210> 2882
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2882
Met Ser Ser Asp Asn Asp Ser Tyr His Ser Asp Glu Phe Leu Thr Asn
 1               5                  10                  15      
Ser Lys Ser
            


<210> 2883
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2883
Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr Pro
 1               5                  10                  15      
Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp
            20                  25                  30          


<210> 2884
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2884
Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro
 1               5                  10                  15      
Asn Lys Phe
            


<210> 2885
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2885
Met Pro Thr Phe Cys Ile Pro Glu Asn His Cys Gly Thr His Ala Pro
 1               5                  10                  15      
Val Trp Leu Asn Gly Ser His Pro Leu Glu Gly Asp Gly Ile Val Gln
            20                  25                  30          
Arg Gln
        


<210> 2886
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2886
Met Pro Asn Ser Ser Gly Leu Met Asn Arg Arg Asp
 1               5                  10          


<210> 2887
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2887
Met Asn Arg Arg Asn Ile Leu Val Met Lys His Asn Tyr Ser Gln Asp
 1               5                  10                  15      
Ala Ala Asp Ala Cys Asp Ile Asp Glu Ile Glu Glu Val Pro Thr Thr
            20                  25                  30          
Ser His Arg Leu
        35      


<210> 2888
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2888
Met Asn Leu Ser Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys
 1               5                  10                  15      
Phe Leu Thr Asp Lys Lys
            20          


<210> 2889
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2889
Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro Ile
 1               5                  10                  15      
Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp Leu
            20                  25                  30          
Arg Arg
        


<210> 2890
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2890
Met Met Ser Val Gln Ala Asn Thr Gly Pro Pro Trp Glu Ser Lys Asn
 1               5                  10                  15      
Ser Thr Ala Val Trp Arg Gly
            20              


<210> 2891
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2891
Met Leu Phe Leu Ser Met Asn Leu Thr Ile Ser Ala Gly Pro Ala Ser
 1               5                  10                  15      
Thr Leu Pro Thr Ala Thr Pro Ala Ala Gly Glu Leu Thr Met Arg Ser
            20                  25                  30          


<210> 2892
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2892
Met Ile Ser Asn Met Ser Glu Glu Ser Ala Asn Met Ile Ala Ser Ala
 1               5                  10                  15      
Leu Ala Gln Ile Pro Gln Lys Val Leu Trp Arg Phe
            20                  25              


<210> 2893
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2893
Met Gly Arg Val Leu Leu Gln Asn Thr Ser Phe Phe Ser Ser Leu Leu
 1               5                  10                  15      
Asn Glu Met Ala His Lys Phe
            20              


<210> 2894
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2894
Met Glu Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala
 1               5                  10                  15      
Gln Cys Ala His Phe Arg Asp
            20              


<210> 2895
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2895
Met Asp Gly Asn Asp Ser Asp Tyr Asp Pro Lys Lys
 1               5                  10          


<210> 2896
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2896
Met Ala Thr Phe Ala Gly Gln Ile Glu Glu Asn Ser Asn Ala Asn Thr
 1               5                  10                  15      
Leu Val Met Ile Leu Asn Ala Thr Asp Ala Asp Glu Pro Asn Asn Leu
            20                  25                  30          
Asn Ser Lys Ile
        35      


<210> 2897
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2897
Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu
 1               5                  10                  15      
Ile Gly Ala Val Ile Ala Gly Arg Asp
            20                  25  


<210> 2898
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2898
Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys Ser Val Ser Pro
 1               5                  10                  15      
Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu Arg Arg
            20                  25                  30  


<210> 2899
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2899
Leu Tyr Asn Asp Ser Thr Tyr Asn Gln Gln Leu Ile Ile Pro Ser Ile
 1               5                  10                  15      
Gly Leu Pro Leu Lys Thr
            20          


<210> 2900
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2900
Leu Thr Lys Arg Thr Asn Met Asp Phe Ser Ile Cys Ile Ser Asn Ile
 1               5                  10                  15      
Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe
            20                  25                  


<210> 2901
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2901
Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val Ser
 1               5                  10                  15      
Val Pro Asn Ala Lys Leu
            20          


<210> 2902
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2902
Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp Thr
 1               5                  10                  15      
Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala
            20                  25          


<210> 2903
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2903
Leu Phe Asn Gly Ser Leu Leu Leu Gln Asn Val Ser Leu Glu Asn Glu
 1               5                  10                  15      
Gly Thr Tyr Val Cys Ile Ala Thr Asn Ala Leu Gly Lys Ala
            20                  25                  30  


<210> 2904
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2904
Lys Tyr His Val Met Ala Pro Ala Leu Ser Phe His Met Ser Pro Trp
 1               5                  10                  15      
Ser Trp Ser Asn Cys Ser Arg Lys Tyr
            20                  25  


<210> 2905
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2905
Lys Tyr Asp Gly Ser Asn Arg Gln Thr Leu Val Asn Thr Thr His Arg
 1               5                  10                  15      
Pro Phe Asp Ile
            20  


<210> 2906
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2906
Lys Trp Thr Asn Leu Ser Asp Pro Met Pro Val Gly Gln Met Gly Thr
 1               5                  10                  15      
Val Lys Tyr
            


<210> 2907
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2907
Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro Val Leu Gly Glu
 1               5                  10                  15      
Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg Arg
            20                  25                  


<210> 2908
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2908
Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Thr Met Pro Thr Leu Asp
 1               5                  10                  15      
Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val
            20                  25              


<210> 2909
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2909
Lys Val Ser Arg Ile Pro Gln Gly Thr Phe Ser Asn Leu Glu Asn Leu
 1               5                  10                  15      
Thr Leu Leu Asp Leu Gln Asn Asn Lys Leu
            20                  25      


<210> 2910
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2910
Lys Val Ser Met Met Glu Lys Ser Glu Leu Val Asn Glu Thr Arg Trp
 1               5                  10                  15      
Gln Tyr Tyr Gly Thr Ala Asn Thr Ser Gly Asn Leu Ser Leu Thr Trp
            20                  25                  30          
His Val Lys Ser
        35      


<210> 2911
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2911
Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp His Leu Gly Asn
 1               5                  10                  15      
Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile
            20                  25      


<210> 2912
<211> 36
<212> PRT
<213> Homo sapiens

<400> 2912
Lys Val Asn Leu Asn Ser Val Ser Lys Ser Leu Thr Gly Leu Ser Asp
 1               5                  10                  15      
Ser Val Ser Gln Tyr Ser Asp Ala Phe Leu Ala Ala Asn Thr Ser Leu
            20                  25                  30          
Asp Glu Arg Glu
        35      


<210> 2913
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2913
Lys Val Asn Gly Ser His Glu Ala Asn Met Leu Ser Gln Val His Arg
 1               5                  10                  15      


<210> 2914
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2914
Lys Val Leu Ser Phe Tyr Asn Val Ser Gln Met Gly Ala Leu Leu Ala
 1               5                  10                  15      
Gly Val Ser Thr Gln Ala Phe Cys
            20                  


<210> 2915
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2915
Lys Val Leu Phe Ile Cys Thr Ala Asn Val Thr Asp Thr Ile Pro Glu
 1               5                  10                  15      
Pro Leu Arg Asp
            20  


<210> 2916
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2916
Lys Val Ile His Val Glu Glu Asn Pro Thr Ser
 1               5                  10      


<210> 2917
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2917
Lys Val Gly Met His Cys Ser Gly Pro Leu Gly Gly Leu Leu Gln Leu
 1               5                  10                  15      
Ala Ala Glu Val Asn Val Thr Ser Arg Val
            20                  25      


<210> 2918
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2918
Lys Thr Tyr Glu Asp Asp Ser Pro Glu Trp Phe Lys Glu Asp Asn Ala
 1               5                  10                  15      
Val Gln Pro Asn Ser Ser Tyr Thr Tyr Val Trp His Ala Thr Glu Arg
            20                  25                  30          
Ser
    


<210> 2919
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2919
Lys Thr Ser Lys Ser Glu Glu Asn Ser Ala Gly Ile Pro Glu Asp Asn
 1               5                  10                  15      
Gly Ser Gln Arg Ile Glu Asp Thr Gln Lys Leu
            20                  25          


<210> 2920
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2920
Lys Thr Pro Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg Phe Ser
 1               5                  10                  15      


<210> 2921
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2921
Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala
 1               5                  10                  15      
Tyr Glu Thr Thr Leu His Val Lys Leu
            20                  25  


<210> 2922
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2922
Lys Thr Lys Leu Pro Glu Tyr Thr Arg Glu Ala Leu Cys Pro Pro Ala
 1               5                  10                  15      
Cys Arg Gly Ser Thr Thr Leu Tyr Asn Cys Ser Thr Cys Lys Gly
            20                  25                  30      


<210> 2923
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2923
Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu Met
 1               5                  10                  15      
Tyr Arg Leu
            


<210> 2924
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2924
Lys Thr Gly Phe Thr Gln Leu Gly Thr Ser Cys Ile Thr Asn His Thr
 1               5                  10                  15      
Cys Ser Asn Ala Asp Glu Thr Phe Cys Glu Met Val Lys Ser
            20                  25                  30  


<210> 2925
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2925
Lys Ser Ser Val Thr Pro Ala Ile Ile Ser Ala Ala Leu Gln Gln Val
 1               5                  10                  15      
Val His Asn Lys Ser
            20      


<210> 2926
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2926
Lys Ser Ser Ile Asn Phe Thr Val Asn Cys Ser Trp Phe Ser Asp Thr
 1               5                  10                  15      
Asn Gly
        


<210> 2927
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2927
Lys Ser Met Ala Asp Val Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr
 1               5                  10                  15      
Ile Ser Glu Gly Pro Ile
            20          


<210> 2928
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2928
Lys Ser Glu Glu Gln Pro Met Asp Leu Glu Asn Arg Ser Thr Ala Asn
 1               5                  10                  15      
Val Leu Glu Glu Thr Thr Val Lys Lys
            20                  25  


<210> 2929
<211> 34
<212> PRT
<213> Homo sapiens

<400> 2929
Lys Arg Tyr Gly Phe Tyr Asn Asn Ser Val Ile Ile Phe Ser Ser Asp
 1               5                  10                  15      
Asn Gly Gly Gln Thr Phe Ser Gly Gly Ser Asn Trp Pro Leu Arg Gly
            20                  25                  30          
Arg Lys
        


<210> 2930
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2930
Lys Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser
 1               5                  10                  15      
Val Val Lys Phe Leu Leu Glu Lys Leu
            20                  25  


<210> 2931
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2931
Lys Gln Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu
 1               5                  10                  15      
Gly Arg Gly
            


<210> 2932
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2932
Lys Asn Gly Leu Ser Asn Ser Ser Ile Leu Leu Asp Lys Cys
 1               5                  10                  


<210> 2933
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2933
Lys Asn Gly Gly Ser Ile Leu Phe Tyr Thr Gly Asn Glu Gly Asp Ile
 1               5                  10                  15      
Ile Trp Phe Cys Asn Asn Thr Gly Phe Met Trp Asp Val Ala Glu Glu
            20                  25                  30          
Leu Lys Ala
        35  


<210> 2934
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2934
Lys Asn Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr
 1               5                  10              


<210> 2935
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2935
Lys Asn Ser Ser Thr Ala Glu Ile Asn Glu Thr Thr Thr Ser Ser Thr
 1               5                  10                  15      
Asp Phe Leu Ala Arg Ala Tyr Gly Phe Glu Met Ala Lys Glu Phe
            20                  25                  30      


<210> 2936
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2936
Lys Asn Arg Ser Thr Ala Ser Ile Gln Pro Thr Ser Asp Asp Leu Val
 1               5                  10                  15      
Ser Ser Ala Glu Cys Ser
            20          


<210> 2937
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2937
Lys Asn Glu Ser Gly Ile Ile Leu Leu Gly Ser Gly Gly Thr Pro Ala
 1               5                  10                  15      
Pro Pro Arg Arg
            20  


<210> 2938
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2938
Lys Met Ala Asp Ala Leu Leu Phe Gly Asn Phe Gly Val Gln Asn Ile
 1               5                  10                  15      
Thr Ala Ala Ile Gln Leu Tyr Glu Ser Leu Ala Lys Glu
            20                  25                  


<210> 2939
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2939
Lys Leu Val Ser Ser Ser Asn Ala Met Glu Asn Ala Ser His Gln Ala
 1               5                  10                  15      
Ser Val Gln Val Glu Ser Leu Gln Glu Gln Leu Asn Val Val
            20                  25                  30  


<210> 2940
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2940
Lys Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Thr Gly Asp
 1               5                  10                  15      
Gly Pro Thr Thr Ala Thr Val Leu Ala Arg Ser
            20                  25          


<210> 2941
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2941
Lys Leu Pro His Asn Gly Ser Thr Gly Ser Thr Pro Leu Leu Arg Asn
 1               5                  10                  15      


<210> 2942
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2942
Lys Leu Pro Gly Leu Ala Asn Thr Thr Leu Ser Thr Pro Asn Pro Asp
 1               5                  10                  15      
Thr Gln Ala Ser Ala Ser Pro Asp Pro Arg Pro
            20                  25          


<210> 2943
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2943
Lys Leu Met Ser Leu Ala Asn Ser Ser Glu Gly Lys Val Asp Lys Val
 1               5                  10                  15      
Leu Met Arg Asn
            20  


<210> 2944
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2944
Lys Leu Leu Lys Glu Gln Ala His Asn Leu Thr Ile Glu Met Lys Asn
 1               5                  10                  15      


<210> 2945
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2945
Lys Leu Glu Lys Asn Ala Thr Asp Asn Ile Ser Lys Leu
 1               5                  10              


<210> 2946
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2946
Lys Leu Cys Ser Ser Val Asn Val Ser Asn Glu Ile Lys Ser
 1               5                  10                  


<210> 2947
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2947
Lys Leu Cys Gly Met Leu Thr Ile Thr Ser Ile Phe Ser Ser Ser Asn
 1               5                  10                  15      
Met Thr Val Ile Tyr Phe Lys Ser
            20                  


<210> 2948
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2948
Lys Lys Asn Ala Asp Asn Asn Ser Ser Ala Phe Thr Ala Leu Ser Glu
 1               5                  10                  15      
Glu Arg Asp
            


<210> 2949
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2949
Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu Ala Pro
 1               5                  10                  15      
Ser Pro Val Asn Ala Met Asn Ser Phe Val
            20                  25      


<210> 2950
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2950
Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn Glu Gly Ser Asn
 1               5                  10                  15      
Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro
            20                  25          


<210> 2951
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2951
Lys Gly Leu Val Glu Gly Val Tyr Cys Asn Leu Thr Glu Ala Phe Glu
 1               5                  10                  15      
Ile Pro Ala Cys Lys Tyr
            20          


<210> 2952
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2952
Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
 1               5                  10                  15      
Tyr Asn Pro Ser Leu Lys Ser Arg Val
            20                  25  


<210> 2953
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2953
Lys Gly Phe Asn Trp Ser Ser Thr Leu Thr Lys His Arg Arg
 1               5                  10                  


<210> 2954
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2954
Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr Leu Ala Asp Ser
 1               5                  10                  15      
Gly Ile Tyr Cys Cys Arg Ile
            20              


<210> 2955
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2955
Lys Gly Ala Cys Asn Gly Ser Val Asp Cys Glu Asp Thr Thr Asn His
 1               5                  10                  15      
Asn Ile Leu Gln Ala Arg Asp
            20              


<210> 2956
<211> 19
<212> PRT
<213> Homo sapiens

<400> 2956
Lys Phe Val Ser Asp Ala Thr Asp Tyr Ala Ala Gly Phe Asn Leu Thr
 1               5                  10                  15      
Tyr Lys Ala
            


<210> 2957
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2957
Lys Phe Asp Ile Leu Met Thr Ser Asn Glu Ile Asn Ala Thr Gly His
 1               5                  10                  15      
Gln Gln Thr Leu Leu Val Pro Ser Glu Asp Gly Ala Thr
            20                  25                  


<210> 2958
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2958
Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu
 1               5                  10                  15      
Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu
            20                  25                  30      


<210> 2959
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2959
Lys Glu Ser Tyr Leu Gln Ile Pro Ser Ala Lys Val Arg Pro Gln Thr
 1               5                  10                  15      
Asn Ile Thr Leu Gln Ile Ala Thr Asp Glu Asp Ser Gly Ile Leu Leu
            20                  25                  30          
Tyr Lys Gly
        35  


<210> 2960
<211> 35
<212> PRT
<213> Homo sapiens

<400> 2960
Lys Glu Gln Tyr Gln Val Leu Ile Gln Ala Lys Asp Met Gly Gly Gln
 1               5                  10                  15      
Leu Gly Gly Leu Ala Gly Thr Thr Ile Val Asn Ile Thr Leu Thr Asp
            20                  25                  30          
Val Asn Asp
        35  


<210> 2961
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2961
Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala Phe Leu Lys Asn Val
 1               5                  10                  15      
Thr Ala Gln Ile Cys Ile Asp Lys Lys
            20                  25  


<210> 2962
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2962
Lys Glu Asn Ser Thr Leu Asn Cys Ala Ser Phe Thr Ala Gly Ile Val
 1               5                  10                  15      
Glu Ala Val Leu Thr His Ser Gly Phe Pro Ala Lys Val
            20                  25                  


<210> 2963
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2963
Lys Glu Ile Arg Val Leu Glu Phe Arg Ser Pro Lys Glu Asn Asp Ser
 1               5                  10                  15      
Gly Val Asp Val Tyr Tyr Ala Val Thr Phe Asn Gly Glu Ala
            20                  25                  30  


<210> 2964
<211> 32
<212> PRT
<213> Homo sapiens

<400> 2964
Lys Glu Gly Glu His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln
 1               5                  10                  15      
Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser
            20                  25                  30          


<210> 2965
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2965
Lys Glu Cys Gln His Gly Gly Gln Cys Gln Val Glu Asn Gly Ser Ala
 1               5                  10                  15      
Val Cys Val Cys Gln
            20      


<210> 2966
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2966
Lys Asp Gly Ser Thr Thr Ala Gly Asn Ser Ser Gln Val Ser Asp Gly
 1               5                  10                  15      
Ala Ala Ala Ile Leu Leu Ala Arg Arg Ser
            20                  25      


<210> 2967
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2967
Lys Asp Phe His Ser Glu Tyr Ile Val Ser Ala Ser Asn Phe Thr Ser
 1               5                  10                  15      
Gln Leu Ser Ser Gln Val Glu Gln Phe Leu His Arg Asn
            20                  25                  


<210> 2968
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2968
Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu Thr Leu Ser Arg
 1               5                  10                  15      
Asn
    


<210> 2969
<211> 17
<212> PRT
<213> Homo sapiens

<400> 2969
Lys Asp Ala Asn Ile Ser Gln Pro Glu Thr Thr Lys Glu Gly Leu Arg
 1               5                  10                  15      
Ala
    


<210> 2970
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2970
Lys Cys Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val
 1               5                  10                  15      


<210> 2971
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2971
Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser
 1               5                  10                  15      
Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Lys
            20                  25                  30          
Phe
    


<210> 2972
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2972
Lys Ala Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu
 1               5                  10                  15      
Asn Leu Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val
            20                  25                  30      


<210> 2973
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2973
Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro Thr Val Leu Arg
 1               5                  10                  15      
Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly Lys Glu
            20                  25                  30  


<210> 2974
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2974
Lys Ala Arg Glu Asp Ile Phe Met Glu Thr Leu Asn Asn Ile Met Glu
 1               5                  10                  15      
Tyr Tyr Asn Asp Ser Asn Gly Gln
            20                  


<210> 2975
<211> 28
<212> PRT
<213> Homo sapiens

<400> 2975
Lys Ala Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys
 1               5                  10                  15      
Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr
            20                  25              


<210> 2976
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2976
Lys Ala Lys Ser Asp Gln Leu Leu Ser Ser Asn Glu Asn Phe Thr Asn
 1               5                  10                  15      
Lys Val
        


<210> 2977
<211> 27
<212> PRT
<213> Homo sapiens

<400> 2977
Lys Ala Gly His Ser Asn Lys Tyr Leu Lys Met Ala Asn Asn Thr Lys
 1               5                  10                  15      
Glu Leu Glu Val Cys Glu Gln Ala Asn Lys Leu
            20                  25          


<210> 2978
<211> 24
<212> PRT
<213> Homo sapiens

<400> 2978
Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr Ile Asn Ala Ser Pro
 1               5                  10                  15      
Ile Met Asp His Asp Pro Arg Asn
            20                  


<210> 2979
<211> 23
<212> PRT
<213> Homo sapiens

<400> 2979
Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu
 1               5                  10                  15      
Gln Thr Asn Glu Thr Arg Thr
            20              


<210> 2980
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2980
Ile Ile Thr Glu Gly Asn Gly Thr Glu Ser Leu Asn Ser Val Ile Thr
 1               5                  10                  15      
Ser Met Lys Thr Gly Glu Leu Glu Lys Glu
            20                  25      


<210> 2981
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2981
His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser Gly Gln
 1               5                  10                  15      
Thr Thr Asn Ile Val Thr His Arg Ala
            20                  25  


<210> 2982
<211> 20
<212> PRT
<213> Homo sapiens

<400> 2982
Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser Leu Ser Asp Ile Gln Pro
 1               5                  10                  15      
Cys Leu Arg Glu
            20  


<210> 2983
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2983
Phe Lys Asn Phe Val Ile Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu
 1               5                  10                  15      
Glu Ala Arg Trp Arg Leu
            20          


<210> 2984
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2984
Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe Arg Gly
 1               5                  10              


<210> 2985
<211> 29
<212> PRT
<213> Homo sapiens

<400> 2985
Asp Leu Leu Arg Thr Leu Asn Asp Thr Leu Gly Lys Leu Ser Ala Ile
 1               5                  10                  15      
Pro Asn Asp Thr Ala Ala Lys Leu Gln Ala Val Lys Asp
            20                  25                  


<210> 2986
<211> 26
<212> PRT
<213> Homo sapiens

<400> 2986
Asp Ala Tyr Tyr Val Tyr Arg Leu Gln Val Ser Ser Ile Asn Val Ser
 1               5                  10                  15      
Val Asn Ala Val Gln Thr Val Val Arg Gln
            20                  25      


<210> 2987
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2987
Cys Asn Ala Thr Asn Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu
 1               5                  10                  15      
Arg Val
        


<210> 2988
<211> 37
<212> PRT
<213> Homo sapiens

<400> 2988
Ala Gln Pro Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn
 1               5                  10                  15      
Gly Ser Gly Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe
            20                  25                  30          
Cys Ala Val Arg Ala
        35          


<210> 2989
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2989
Ala Ile Met Asn Asn Met Ser Leu Ile Ile His Arg Ser
 1               5                  10              


<210> 2990
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2990
Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln Glu Asp Thr Gly Ser
 1               5                  10                  15      
Tyr Thr Leu His Ile Ile Lys Arg Gly
            20                  25  


<210> 2991
<211> 30
<212> PRT
<213> Homo sapiens

<400> 2991
Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr Thr Gly Glu
 1               5                  10                  15      
Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys Leu
            20                  25                  30  


<210> 2992
<211> 16
<212> PRT
<213> Homo sapiens

<400> 2992
Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala Pro Ser Pro Pro Arg Arg
 1               5                  10                  15      


<210> 2993
<211> 25
<212> PRT
<213> Homo sapiens

<400> 2993
Tyr Asn Gln Ser Thr Ala Thr Thr Leu Phe His Ser Leu Pro Leu Leu
 1               5                  10                  15      
Arg Tyr Ile Phe Val Arg Glu Arg Val
            20                  25  


<210> 2994
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2994
Trp Glu Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly
 1               5                  10                  15      
Leu Gly Leu Leu Arg Val
            20          


<210> 2995
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2995
Val Asn Ala Leu Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe Val Glu
 1               5                  10                  15      
Leu Asn Ala Ala Arg Tyr
            20          


<210> 2996
<211> 33
<212> PRT
<213> Homo sapiens

<400> 2996
Thr Gln His Phe Tyr Leu Asn Phe Thr Ile Thr Asn Leu Pro Tyr Ser
 1               5                  10                  15      
Gln Asp Lys Ala Gln Pro Gly Thr Thr Asn Tyr Gln Arg Asn Lys Arg
            20                  25                  30          
Asn
    


<210> 2997
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2997
Thr Asn Gln Thr Pro Pro Thr Tyr Asn Lys Thr Asn Lys Phe
 1               5                  10                  


<210> 2998
<211> 15
<212> PRT
<213> Homo sapiens

<400> 2998
Thr Asn Cys Thr Thr Glu Ala Ser Met Ala Ile Arg Pro Lys Thr
 1               5                  10                  15  


<210> 2999
<211> 12
<212> PRT
<213> Homo sapiens

<400> 2999
Thr Met Asn Pro Leu Ile Tyr Asn Ile Thr Arg Val
 1               5                  10          


<210> 3000
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3000
Thr Leu Thr His Ala Thr Asn Phe Leu Asn Val Met Leu Gln Ser Asn
 1               5                  10                  15      
Lys Ser
        


<210> 3001
<211> 39
<212> PRT
<213> Homo sapiens

<400> 3001
Thr Ile Thr Met Ile Pro Asn Thr Leu Thr Gly Met Gln Pro Leu His
 1               5                  10                  15      
Thr Phe Asn Thr Phe Ser Gly Gly Gln Asn Ser Thr Asn Leu Pro His
            20                  25                  30          
Gly His Ser Thr Thr Arg Val
        35                  


<210> 3002
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3002
Thr Asp Cys Gly His Thr Trp Asn Ser Pro Asn Cys Thr Asp Pro Lys
 1               5                  10                  15      
Leu Leu Asn Gly Ser Val Leu Gly Asn His Thr Lys Tyr
            20                  25                  


<210> 3003
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3003
Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val Met
 1               5                  10                  15      
Cys Pro Asn Met Pro Asn Lys Ser
            20                  


<210> 3004
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3004
Ser Gln Ile Ser Thr Ser Thr Met Thr Val Thr His Asn Ser Ser Val
 1               5                  10                  15      
Thr Ser Ala Ala Ser Ser Val Thr Ile Thr Thr Thr Met His Ser Glu
            20                  25                  30          
Ala Lys Lys
        35  


<210> 3005
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3005
Ser Leu Pro Met Ser Ile Asn Val Thr Asp Asp Ile Val Tyr Ile Ser
 1               5                  10                  15      
Thr His Pro Glu Ala Ser Ser Arg Thr
            20                  25  


<210> 3006
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3006
Ser Leu Glu Arg Phe Ile His Gly Gly Ala Asn Val Thr Gly Phe Gln
 1               5                  10                  15      
Leu Val Asp Phe Asn Thr Pro Met Val Thr Lys Leu
            20                  25              


<210> 3007
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3007
Arg Tyr Ser Lys Glu Thr Asn Ile Asp Pro Ser Glu Asn Ser Thr Ser
 1               5                  10                  15      
Asn Leu Pro Asn Cys Leu Ile Asn Gln Met Leu Ser Leu Asn Arg Thr
            20                  25                  30          


<210> 3008
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3008
Arg Tyr Pro Ile Ile Met Asn Lys Val Val Tyr Val Leu Leu Thr Ser
 1               5                  10                  15      
Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Thr Val Gln Thr Ser Leu
            20                  25                  30          
Ala Met Arg Trp
        35      


<210> 3009
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3009
Arg Tyr Leu Ile Asn Ser Tyr Asp Phe Val Asn Asp Thr Leu Ser Leu
 1               5                  10                  15      
Lys His
        


<210> 3010
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3010
Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val Val Leu Ser Glu Asn
 1               5                  10                  15      
Ile Pro Leu Asn Thr Lys Ile Ala
            20                  


<210> 3011
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3011
Arg Trp Leu Ser Ser Thr Gly Pro Glu Cys Asn Cys Ser Leu Gly Asn
 1               5                  10                  15      
Phe Asp Ser Gln Val Gly Ala Cys Gly Phe Asn Ser Arg Ile
            20                  25                  30  


<210> 3012
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3012
Arg Trp His Ile Asn Phe Thr Thr Phe Phe Ile Asp Cys Met Ala Ala
 1               5                  10                  15      
Phe Gly Leu Ala Tyr Asp Gln Lys Lys
            20                  25  


<210> 3013
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3013
Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg
 1               5                  10                  15      
Gly Lys Thr
            


<210> 3014
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3014
Arg Val Ser Gly Tyr Leu Asn Leu Ala Ala Asp Leu Ala His Asn Phe
 1               5                  10                  15      
Thr Asp Gly Leu Ala Ile Gly Ala Ser Phe Arg Gly Gly Arg Gly
            20                  25                  30      


<210> 3015
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3015
Arg Val Ser Gly Ala Val Ala Thr Ala Val Leu Trp Val Leu Ala Ala
 1               5                  10                  15      
Leu Leu Ala Met Pro Val Met Val Leu Arg Thr Thr Gly Asp Leu Glu
            20                  25                  30          
Asn Thr Thr Lys Val
        35          


<210> 3016
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3016
Arg Val Gln Pro Ala Gln Asn His Ser Ser Leu Ser Asn Val Ser Gln
 1               5                  10                  15      
Ala Val Ala Ser Thr Thr Pro Leu Pro Pro Pro Lys Pro
            20                  25                  


<210> 3017
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3017
Arg Val Met Val His Gly Arg Asn His Thr Pro Phe Leu Gly His His
 1               5                  10                  15      
Ser Phe
        


<210> 3018
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3018
Arg Val Lys Lys Met Ala Met Phe Val Val Ala Gly Phe Asn Leu Ser
 1               5                  10                  15      
Ser Ser Leu Phe Ile Ile Leu Leu Ser Tyr Leu Phe Ile Phe Ala Ala
            20                  25                  30          
Ile Phe Arg Ile
        35      


<210> 3019
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3019
Arg Val Gly Val Asp Pro Asp Gln Asp Pro Pro Pro Asn Asn Asp Ser
 1               5                  10                  15      
Phe Gln Val Leu Gln Gly Asp Ser Pro Asp Ser Ala Arg Gly
            20                  25                  30  


<210> 3020
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3020
Arg Val Gly Leu Phe Cys Gly Ile Phe Ile Val Leu Asn Ile Thr Leu
 1               5                  10                  15      
Val Leu Ala Ala Val Phe Lys Leu
            20                  


<210> 3021
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3021
Arg Val Phe Tyr Phe Met Val Gly Thr Ala Phe Ala Asn Ser Thr Cys
 1               5                  10                  15      
Gln Leu Ile Val Cys Gln Met Ser Ser Thr Arg Cys
            20                  25              


<210> 3022
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3022
Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser Asp Ala Tyr Leu
 1               5                  10                  15      
Asn Ala Ser
            


<210> 3023
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3023
Arg Thr Pro Arg Pro Ala Ser Thr His Asn Gly Ser Val Asp Thr Glu
 1               5                  10                  15      
Asn Asp Ser Cys Leu Gln Gln Thr His
            20                  25  


<210> 3024
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3024
Arg Thr Asn Gly Asp Ile Leu Val Leu Tyr Asn Leu Ser Lys His
 1               5                  10                  15  


<210> 3025
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3025
Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala Asp Gly Lys
 1               5                  10                  15      
Phe
    


<210> 3026
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3026
Arg Thr Ile Thr Asn Val Ser Asp Glu Val Ser Ser Glu Glu Gly Pro
 1               5                  10                  15      
Glu Thr Gly Tyr Ser Leu Arg Arg His
            20                  25  


<210> 3027
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3027
Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro Ser
 1               5                  10                  15      
Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser
            20                  25                  


<210> 3028
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3028
Arg Ser Asn Ser Ser Ala Ala Asn Leu Met Ala Lys Lys Arg
 1               5                  10                  


<210> 3029
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3029
Arg Ser Asn Leu Thr Ser Phe Gly Ala Asp Gln Val Met Asp Leu Gly
 1               5                  10                  15      
Arg Asp
        


<210> 3030
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3030
Arg Ser Leu Val Pro Thr Leu Arg Glu Met Val Ala Phe Leu Asn Val
 1               5                  10                  15      
Ser Val Ser Glu Glu Arg Leu
            20              


<210> 3031
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3031
Arg Ser Leu Lys Glu Ala Phe Ser Asn Phe Ser Ser Ser Thr Leu Thr
 1               5                  10                  15      
Glu Val Gln Ala Ile Ser Thr His Gly Gly Ser Val Gly Asp Lys Ile
            20                  25                  30          


<210> 3032
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3032
Arg Ser Leu Ile Ala Ser Gly Leu Tyr Gly Tyr Asn Ala Thr Leu Val
 1               5                  10                  15      
Gly Val Leu Met Ala Val Phe Ser Asp Lys Gly
            20                  25          


<210> 3033
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3033
Arg Ser Leu Ala Ile Thr Leu Pro Glu Pro Asn Gly Ser Ala Thr Gly
 1               5                  10                  15      
Leu Thr Val Trp Leu His
            20          


<210> 3034
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3034
Arg Ser Lys Asp Gly Pro Ser Tyr Phe Thr Val Ser Phe Asn Arg Thr
 1               5                  10                  15      
Phe Leu Met Met Ile Thr Asn Lys Ala
            20                  25  


<210> 3035
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3035
Arg Ser Ile Thr Asn Ala Ser Ala Ala Ile Ala Pro Lys Asp Asn Leu
 1               5                  10                  15      
Phe Ile Arg Phe Leu Lys Pro
            20              


<210> 3036
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3036
Arg Ser Glu His Thr Gly Ala Cys Asn Pro Cys Thr Glu Gly Val Asp
 1               5                  10                  15      
Tyr Thr Asn Ala Ser Asn Asn Glu Pro Ser Cys Phe Pro Cys Thr Val
            20                  25                  30          
Cys Lys Ser
        35  


<210> 3037
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3037
Arg Arg Tyr Thr Asn Ser Ser Ala Asp Asn Glu Glu Cys Arg Val Pro
 1               5                  10                  15      


<210> 3038
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3038
Arg Arg Val Tyr Asp Phe Val Gly Leu Leu Val Ser Pro Glu Met Glu
 1               5                  10                  15      
Gln Phe Ala Leu Asn Met Thr Ser
            20                  


<210> 3039
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3039
Arg Arg Arg Gly Arg Pro Arg Gly Asn Asn Leu Ser Thr Ile Ser Asp
 1               5                  10                  15      
Thr Ser Pro Met Lys Arg Ser
            20              


<210> 3040
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3040
Arg Arg Asn Ser Asn Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg
 1               5                  10                  15      


<210> 3041
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3041
Arg Arg Asn Asn Ser Ile Arg Arg Asn Asn Ser Ser Leu Met Val Pro
 1               5                  10                  15      
Lys Val
        


<210> 3042
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3042
Arg Arg Asn Cys Thr Leu Val Thr Glu Phe Ile Leu Leu Gly Leu Thr
 1               5                  10                  15      
Ser Arg
        


<210> 3043
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3043
Arg Arg Ile Trp Glu Glu Thr Gly Asn Tyr Thr Phe Ser Ser Asp
 1               5                  10                  15  


<210> 3044
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3044
Arg Arg Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu
 1               5                  10                  15      
Glu Ala Ser Val Leu Ser Ser His His Lys Lys
            20                  25          


<210> 3045
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3045
Arg Arg Asp Arg Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu
 1               5                  10                  15  


<210> 3046
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3046
Arg Gln Arg Asn Ala Ser Arg Asp Gln Val
 1               5                  10  


<210> 3047
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3047
Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu Ala
 1               5                  10                  


<210> 3048
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3048
Arg Gln Asn Ile Ala Ile Glu Val Asp Ala Phe Gly Thr Arg Asn Gly
 1               5                  10                  15      
Thr Asp Asp Pro Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Asp Glu
            20                  25                  30          
Lys Asp
        


<210> 3049
<211> 40
<212> PRT
<213> Homo sapiens

<400> 3049
Arg Gln Asn Asn Thr Ser Leu Arg Leu Gly Val Tyr Ala Ala Leu Gly
 1               5                  10                  15      
Ile Leu Gln Gly Phe Leu Val Met Leu Ala Ala Met Ala Met Ala Ala
            20                  25                  30          
Gly Gly Ile Gln Ala Ala Arg Val
        35                  40  


<210> 3050
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3050
Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Met Phe Asn
 1               5                  10                  15      
Lys Asn Gly Asp Ala Pro Gly Arg Tyr
            20                  25  


<210> 3051
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3051
Arg Asn Val Asp Ser Asn Leu Ala Asn Leu Ile Met Asn Glu Ile Val
 1               5                  10                  15      
Asp Asn Gly Thr Ala Val Lys Phe
            20                  


<210> 3052
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3052
Arg Asn Ser Asn Val Ser Gln Ala Ser Met Ser Ser Arg Met
 1               5                  10                  


<210> 3053
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3053
Arg Asn Ser Lys Asn Cys Thr Glu Pro Ala Leu His Glu Phe Pro Asn
 1               5                  10                  15      
Asp Ile Phe Thr Asn Glu Asp Arg Arg Gln
            20                  25      


<210> 3054
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3054
Arg Asn Val Thr Val Gly Pro Pro Glu Asn Ile Glu Val Thr Pro Gly
 1               5                  10                  15      
Glu Gly Ser Leu Ile Ile Arg Phe
            20                  


<210> 3055
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3055
Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu Tyr Tyr Trp His Arg
 1               5                  10                  15      
Ser
    


<210> 3056
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3056
Arg Asn Arg Ser Tyr Val Phe Ser Ser Leu Ala Thr Ser Ala Val Ser
 1               5                  10                  15      
Phe Ala Thr Gly Ala Leu Gly Met Trp Ile Pro Leu Tyr Leu His Arg
            20                  25                  30          
Ala
    


<210> 3057
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3057
Arg Asn Asn Ser Lys Gly Tyr Met Lys Leu Glu Asn Lys Glu Asp Pro
 1               5                  10                  15      
Met Asp Arg Leu Leu Val
            20          


<210> 3058
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3058
Arg Asn Leu Ser Val Asp Gly Lys Asn Val Asp Met Ala Gly Phe Ile
 1               5                  10                  15      
Ala Asn Asn Gly Thr Arg Glu Gly Cys
            20                  25  


<210> 3059
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3059
Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp Leu Phe
 1               5                  10              


<210> 3060
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3060
Arg Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ile Pro
 1               5                  10                  15      
Gln Met Leu Val
            20  


<210> 3061
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3061
Arg Asn Gly Ser Asp Asp Pro Ser Tyr Asn Gly Ala Ile Ile Val Ser
 1               5                  10                  15      
Gly Asp Gln Lys Asp
            20      


<210> 3062
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3062
Arg Met Trp Arg Arg Ala Thr Val Ala Ala Gly Asn Ser Val Val Gln
 1               5                  10                  15      
Val Val Asn Val Ser Arg Leu Glu Gly Asp Asp Asn Pro Val Gln Leu
            20                  25                  30          
Ile
    


<210> 3063
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3063
Arg Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val
 1               5                  10                  15      
Asn Glu Thr Asp Asp Thr Lys Met
            20                  


<210> 3064
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3064
Arg Met Phe Thr Asn Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg
 1               5                  10                  15      
Asn Leu
        


<210> 3065
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3065
Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile Met
 1               5                  10                  15      
Arg Glu
        


<210> 3066
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3066
Arg Met Cys Gln Ala Gly Asn Ala Thr Val Lys Gln Ser Arg Tyr Arg
 1               5                  10                  15      
Ile
    


<210> 3067
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3067
Arg Leu Tyr Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu Val Leu
 1               5                  10                  15      
Ile Arg Asn Leu Arg Ile Leu Thr Ile Phe Ser Met Leu Ala Asn Ile
            20                  25                  30          
Ser Met Leu Val
        35      


<210> 3068
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3068
Arg Leu Val Ser Asn Asp Ser Phe Ile Ser Ile Gln Pro Ser Leu Ser
 1               5                  10                  15      
Ser Cys Gly Gln Asp Leu Pro Arg Asp
            20                  25  


<210> 3069
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3069
Arg Leu Ser Tyr Asn Val Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg
 1               5                  10                  15      
Val Ala Asp Gln Leu Trp Val Pro Asp
            20                  25  


<210> 3070
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3070
Arg Leu Met Arg Gln Leu Leu Val Ile Asn Glu Ser Ile Glu Ser Ile
 1               5                  10                  15      
Lys Trp
        


<210> 3071
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3071
Arg Leu Leu Asn Leu Ser Leu Asn Ser Glu Val Val Leu Asp Gln Asp
 1               5                  10                  15      
Ala Ile Asp Val Ile Ile His Val Ala Arg Asn
            20                  25          


<210> 3072
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3072
Arg Leu Cys Gln Thr Cys Tyr Pro Leu Phe Gln Gln Val Val Ser Lys
 1               5                  10                  15      
Met Asp Asn Ile Ser Arg Ala
            20              


<210> 3073
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3073
Arg Leu Ala Val Thr Asn Leu Thr Ala Val Asn Leu Leu Ala Tyr Val
 1               5                  10                  15      
Gly Asp Leu Val Tyr Ser Ala His Leu Val Phe Val Lys Val
            20                  25                  30  


<210> 3074
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3074
Arg Leu Ala Glu Asn Ser Gly Asn Ala Ser Thr Glu Arg Asn
 1               5                  10                  


<210> 3075
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3075
Arg Lys Thr Asn Glu Leu Pro Ser Asp Ser Ser Ser Ser Ser Asp Leu
 1               5                  10                  15      
Ile Asn Thr Ser Ile Ala Ser Ser
            20                  


<210> 3076
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3076
Arg Lys Gln Pro Met Thr Leu Thr Val Thr Ser Phe Asn Ala Ser Thr
 1               5                  10                  15      
Gly Arg Val Asn Ala Thr Leu Ser Asn Ser Asn Met Glu Leu Leu Leu
            20                  25                  30          
Ser Gly Val Tyr Lys
        35          


<210> 3077
<211> 40
<212> PRT
<213> Homo sapiens

<400> 3077
Arg Lys Gln Ala Gly Pro Leu Leu Ser Gly Asp Pro His Leu Leu Pro
 1               5                  10                  15      
Pro Ala Ala Ser Pro Lys Gly Ala Ser Val Ser Ile Asn Val Asn Thr
            20                  25                  30          
Ser Leu Glu Asp Met Arg Ser Asn
        35                  40  


<210> 3078
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3078
Arg Lys Asn Lys Ser Val Trp Ile Thr Ile Ser Ser Thr
 1               5                  10              


<210> 3079
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3079
Arg Lys Leu Leu Phe Leu Ser Pro Asp Leu Glu Leu Asn Ser Ser Ser
 1               5                  10                  15      
Ser His Asn Thr Leu
            20      


<210> 3080
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3080
Arg Lys Gly Ile Ile Asp Val Asn Leu Tyr Asn Glu Thr Val Glu Thr
 1               5                  10                  15      
Leu Met Ala Gly Glu
            20      


<210> 3081
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3081
Arg Ile Tyr Pro Gly Pro Thr Arg Leu Ala Asn Ser Thr Ile Lys Asp
 1               5                  10                  15      
Glu Ser Pro Pro Arg Tyr
            20          


<210> 3082
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3082
Arg Ile Val Asp Gly Ile Glu Asp Gly Asn Ser Ser Glu Glu Ser Gln
 1               5                  10                  15      
Thr Phe Asp Phe Gly Ser Glu Arg Ile
            20                  25  


<210> 3083
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3083
Arg Ile Leu Ser Asn Met Thr Phe Leu Phe Val Ser Leu Ser Tyr Thr
 1               5                  10                  15      
Ala Glu Ser Ala Ile Val Thr Ala Phe Ile Thr Phe Ile Pro
            20                  25                  30  


<210> 3084
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3084
Arg Ile Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn
 1               5                  10                  15      
Leu Ser Phe Val Asp Val Cys Asn Ser Thr Thr Ile Thr Pro Lys Met
            20                  25                  30          


<210> 3085
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3085
Arg Ile Ala Gln Lys Gly Gly Ala Glu Ala Met Leu Val Val Asn Asn
 1               5                  10                  15      
Ser Val Leu Phe Pro Pro Ser Gly Asn Arg Ser
            20                  25          


<210> 3086
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3086
Arg Ile Ala Glu Asn Tyr Thr Ala Val Val Ser Pro Asp Ile Ala Ser
 1               5                  10                  15      
Ile Asp Leu Asn Thr Phe Glu Phe Asn Lys Pro
            20                  25          


<210> 3087
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3087
Arg His Cys Ser Val Asn Gly Thr Trp Thr Gly Ser Asp Pro Glu Cys
 1               5                  10                  15      
Leu Val Ile Asn Cys Gly Asp Pro Gly Ile Pro Ala Asn Gly Leu Arg
            20                  25                  30          
Leu
    


<210> 3088
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3088
Arg Gly Tyr Pro Gly Gln Val Cys Ala Asn Asp Ser Asp Thr Leu Glu
 1               5                  10                  15      
Leu Pro Asp Ser Ser Arg Ala Leu Leu Leu Gly Trp Val Pro Thr Arg
            20                  25                  30          
Leu
    


<210> 3089
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3089
Arg Gly Ser Asp Asp Gly Asp Gly Glu Ser Phe Asn Gly Ser Pro Thr
 1               5                  10                  15      
Gly Ser Ile Asn Leu Ser Leu Asp
            20                  


<210> 3090
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3090
Arg Gly Gln Gly Thr Ala Ser Ser Gly Asn Val Ser Asp Leu Ala Gln
 1               5                  10                  15      
Thr Val Lys Thr Phe Asp Asn Leu Lys Thr
            20                  25      


<210> 3091
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3091
Arg Gly Asn Ile Tyr Pro Gly Asn Asp Thr Phe Asp Ile Asp Pro Glu
 1               5                  10                  15      
Ile Glu Thr
            


<210> 3092
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3092
Arg Gly Glu Arg His Gly Asp Ile Phe Met Asn Arg Thr Glu Asn Trp
 1               5                  10                  15      
Ile Gly Ser Gln Tyr Lys Lys Val
            20                  


<210> 3093
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3093
Arg Phe Tyr Lys Phe Asn Thr Ser Leu Ala Gly Asp Leu Thr Asn Leu
 1               5                  10                  15      
Val His Gly Ser His Cys
            20          


<210> 3094
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3094
Arg Phe Tyr Ile Ser Lys Gly Ala Val Val Asp Gln Leu Gly Gly Asp
 1               5                  10                  15      
Leu Asn Ser Thr Pro Leu His Trp Ala Ile Arg Gln
            20                  25              


<210> 3095
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3095
Arg Phe Arg Asp Ile Pro Asn Thr Ser Ser Met Glu Asn Pro Ala Pro
 1               5                  10                  15      
Asn Lys Asn
            


<210> 3096
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3096
Arg Phe Pro Gly Val Met Glu Asn Leu Thr Ile Ser Ala Ala His Trp
 1               5                  10                  15      
Leu Thr Ala Pro Ala Pro Arg Pro Arg Pro Arg Arg
            20                  25              


<210> 3097
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3097
Arg Phe Leu Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala
 1               5                  10                  15      
Thr Val Ile Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys
            20                  25                  30          
Tyr
    


<210> 3098
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3098
Arg Phe Ile Asn Ser Thr Phe Leu Glu Gln Lys Glu
 1               5                  10          


<210> 3099
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3099
Arg Phe Ile Asp Ser Ser Asn Pro Gly Leu Gln Ile Ser Leu Asn Val
 1               5                  10                  15      
Asn Asn Thr Glu His Val Val Ser Ile
            20                  25  


<210> 3100
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3100
Arg Phe Asp Gly Ile Leu Ala Asp Ala Gly Gln Thr Val Glu Asn Met
 1               5                  10                  15      
Ser Trp Met Leu Val Cys Asp Arg Pro
            20                  25  


<210> 3101
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3101
Arg Phe Cys His Glu Val Lys Ile Asn Tyr Ser Pro Tyr Val Asn Tyr
 1               5                  10                  15      
Phe Thr Arg Val Tyr Trp Asn Arg Ser
            20                  25  


<210> 3102
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3102
Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr Thr Glu Lys
 1               5                  10                  15      


<210> 3103
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3103
Arg Glu Trp Asn Gly Thr Tyr His Cys Ile Phe Arg Tyr
 1               5                  10              


<210> 3104
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3104
Arg Glu Thr Pro Pro Leu Glu Asp Leu Ala Ala Asn Gln Ser Glu Asp
 1               5                  10                  15      
Pro Arg Asn Gln Arg Leu Ser Lys Asn
            20                  25  


<210> 3105
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3105
Arg Glu Thr Gly Asp Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile
 1               5                  10                  15      
Met Gly Ile Glu Ile
            20      


<210> 3106
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3106
Arg Glu Arg Glu Ser Phe Leu Ala Pro Ser Ser Gly Val Gln Pro Thr
 1               5                  10                  15      
Leu Ala Met Pro Asn Ile Ala Val Gly Gln Asn Val Thr Val Thr Glu
            20                  25                  30          
Arg Val
        


<210> 3107
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3107
Arg Glu Gln Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln
 1               5                  10                  15      
Ile Gln Lys Ala
            20  


<210> 3108
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3108
Arg Glu Pro Gly Thr Ser Ser Thr Ser Asn Leu Ser Ser Thr Ser His
 1               5                  10                  15      
Glu Arg Leu
            


<210> 3109
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3109
Arg Glu Pro Ala Gln Gly Leu Phe Gly Thr Val Thr Val Gln Phe Ile
 1               5                  10                  15      
Val Thr Glu Val Asn Ser Ser Asn Glu Ser Lys Asp
            20                  25              


<210> 3110
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3110
Arg Glu Asn Glu Thr Glu Ile Ile Lys Cys
 1               5                  10  


<210> 3111
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3111
Arg Glu Leu Gly Gly Ala Ile Asp Phe Gly Ala Ala Tyr Val Leu Glu
 1               5                  10                  15      
Gln Ala Ser Ser His Ile Gly Asn Ser Thr Gln Ala Thr Val Arg Asp
            20                  25                  30          


<210> 3112
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3112
Arg Glu Leu Asp Leu Pro Ser Gln Asp Asn Val Ser Leu Thr Ser Thr
 1               5                  10                  15      
Glu Thr Pro Pro Pro Leu Tyr Val Gly
            20                  25  


<210> 3113
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3113
Arg Glu Leu Ala Ile Thr Asp Ser Glu His Ser Asp Ala Glu Val Ser
 1               5                  10                  15      
Cys Thr Asp Asn Gly Thr Phe Asn Leu Ser Arg Gly
            20                  25              


<210> 3114
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3114
Arg Glu His Met Glu Ser Asn Leu Phe Leu Ser Cys Ala Thr Asn Gln
 1               5                  10                  15      
Ser Pro Val Glu Lys Asp
            20          


<210> 3115
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3115
Arg Glu Gly Asp Asn Arg Glu Arg Ala Leu Asn Thr Thr Gln Pro Gly
 1               5                  10                  15      
Ser Leu Gln Leu Thr Val Gly Asn Leu Lys Pro
            20                  25          


<210> 3116
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3116
Arg Glu Asp Phe His Tyr Asn Asp Thr Ala Gly Tyr Phe Ile Ile Gly
 1               5                  10                  15      
Gly Ser Arg Tyr Val Ala Gly Ile Glu Gly Phe Phe Gly Pro Leu Lys
            20                  25                  30          
Tyr
    


<210> 3117
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3117
Arg Glu Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys
 1               5                  10                  15      
Asn Leu Asn Leu Lys Leu Arg Pro
            20                  


<210> 3118
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3118
Arg Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser Glu Ser Gly Gly Leu
 1               5                  10                  15      
Asn Trp Lys Met Thr
            20      


<210> 3119
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3119
Arg Asp Arg Leu Ala Leu Ala Asn Glu Ser Gly Val Thr Leu Met Pro
 1               5                  10                  15      
Asp Gly Ser Leu His Leu Ala Ala Leu Pro Ser Arg Arg
            20                  25                  


<210> 3120
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3120
Arg Asp Leu Asp Gly Phe Leu Ala Gln Ala Ser Ile Val Leu Asn Glu
 1               5                  10                  15      
Thr Ala Thr Ser Leu Asp Asn Val Leu Arg Thr Met Leu Arg Arg Phe
            20                  25                  30          


<210> 3121
<211> 40
<212> PRT
<213> Homo sapiens

<400> 3121
Arg Asp Gly Thr Leu Glu Tyr Ala Pro Val Asp Ile Thr Val Asn Leu
 1               5                  10                  15      
Asp Ala Ser Gly Ser Gln Cys Gly Leu His Ser Pro Leu Gln Ser Asp
            20                  25                  30          
Asn Ala Thr Asp Ser Pro Lys Ser
        35                  40  


<210> 3122
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3122
Arg Cys Pro Gln Cys Asp Cys Ile Thr Leu Gln Asn Val Ser Ala Gly
 1               5                  10                  15      
Leu Asn His His Gln Thr Phe Ser
            20                  


<210> 3123
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3123
Arg Cys Ile Thr Cys Ala Val Val Gly Asn Gly Gly Ile Leu Asn Asn
 1               5                  10                  15      
Ser His Ile Gly Gln Glu Ile Asp Ser His Asp
            20                  25          


<210> 3124
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3124
Arg Cys Glu Ala Leu Cys Gly Gly Asn Ile Thr Ala Met Asn Gly Thr
 1               5                  10                  15      
Ile Tyr Ser
            


<210> 3125
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3125
Arg Ala Val Phe Ile Gln Gly Ala Glu Glu His Pro Ala Ala Phe Cys
 1               5                  10                  15      
Tyr Gln Val Asn Gly Ser Cys Pro Arg Thr
            20                  25      


<210> 3126
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3126
Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala
 1               5                  10                  15      
Gln Glu Ser Ile Ile Lys Gly
            20              


<210> 3127
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3127
Arg Ala Leu Gln Trp Asn Ala Gly Ser Gly Gly Leu Pro Glu Asn Glu
 1               5                  10                  15      
Thr Thr Phe Ala Arg Ile Leu Gln
            20                  


<210> 3128
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3128
Gln Val Gly Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys
 1               5                  10                  15      


<210> 3129
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3129
Gln Ser Thr Met Leu Asp Thr Asn Ser Trp Ile Phe Ala Cys Ile Asn
 1               5                  10                  15      
Ser Thr Ser Met Cys Leu Gln Gly Val Asp Leu Ser Trp Lys Ala
            20                  25                  30      


<210> 3130
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3130
Gln Asn Ile Thr Glu Glu Ile Pro Met Glu Val Phe Lys Glu
 1               5                  10                  


<210> 3131
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3131
Gln Lys Ala Met Phe Asp His Leu Ser Tyr Leu Leu Glu Asn Ser Ser
 1               5                  10                  15      
Val Gly Leu Ala Ser Pro Ala Met Arg Gly
            20                  25      


<210> 3132
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3132
Pro Thr Asn Glu Thr Thr Phe Ala Lys Leu
 1               5                  10  


<210> 3133
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3133
Pro Ser Ser Leu Ile Gln Ala Asn Val Thr Val Gly Thr Cys Ser Gly
 1               5                  10                  15      
Phe Cys Ser Gln Lys Glu Phe Pro Leu Ala Ile Leu Arg Gly
            20                  25                  30  


<210> 3134
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3134
Pro Ser Ser Glu Val Met Asn Lys Ser Arg Cys Glu Ser Leu Leu Phe
 1               5                  10                  15      
Asn Glu Ser Met Leu Trp Glu Asn Ala Lys Met
            20                  25          


<210> 3135
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3135
Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile Met Pro Gly Gly
 1               5                  10                  15      
Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val
            20                  25                  30          
Lys Trp
        


<210> 3136
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3136
Pro His Met Leu Pro Glu Asp Gly Ala Asn Leu Ser Ser Ala Arg Gly
 1               5                  10                  15      
Ile Leu Ser Leu Ile Gln Ser Ser Thr Arg Arg
            20                  25          


<210> 3137
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3137
Pro Gly Asn Leu Pro Pro Ser Met Asn Leu Ser Gln Leu Leu Gly Leu
 1               5                  10                  15      
Arg Lys Asn
            


<210> 3138
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3138
Pro Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val
 1               5                  10                  15      


<210> 3139
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3139
Asn Val Gly Gln Asn Thr Thr Arg Phe
 1               5                  


<210> 3140
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3140
Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu Ala
 1               5                  10                  15      
Pro Gly Lys Gly
            20  


<210> 3141
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3141
Asn Gln Ala Gly Asp Thr Ser Asn Gln Ser Ser Gly Pro His
 1               5                  10                  


<210> 3142
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3142
Asn Pro Asp Ala Ser Tyr Asn Leu Gly Val Leu His Leu Asp Gly Ile
 1               5                  10                  15      
Phe Pro Gly Val Pro Gly Arg Asn Gln Thr Leu Ala Gly Glu Ile Phe
            20                  25                  30          
His Lys Ala
        35  


<210> 3143
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3143
Asn Asn Tyr Thr Ala Val Phe Leu Gly Thr Val Asn Gly Arg Leu
 1               5                  10                  15  


<210> 3144
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3144
Asn Asn Ala Thr Asn Glu Ser Tyr Val Asp Thr Ala Ala Met Glu Ala
 1               5                  10                  15      
Glu Arg Leu
            


<210> 3145
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3145
Asn Glu Ile Asn Asn Met Ser Phe Leu Thr Ala Asp Asn Lys Ser
 1               5                  10                  15  


<210> 3146
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3146
Asn Asp Gln Leu Ser Glu Ile Glu Glu Phe Phe Tyr Ile Asn Leu Thr
 1               5                  10                  15      
Ser Val Glu Ile Arg Gly Leu Gln Lys Phe
            20                  25      


<210> 3147
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3147
Asn Cys Thr Cys Val Gly Ile Ala Ala Ser Lys Ser Gly Asn Ser Ser
 1               5                  10                  15      
Gly Ile Val Gly Arg Cys Gln Lys Asp
            20                  25  


<210> 3148
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3148
Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Ala Asp Ala Cys Phe Val
 1               5                  10                  15      
Ser Thr Thr Val Pro Lys Met
            20              


<210> 3149
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3149
Met Trp Ser His Met Gln Pro His Leu Phe His Asn Gln Ser Val Leu
 1               5                  10                  15      
Ala Glu Gln Met Ala Leu Asn Lys Lys Phe
            20                  25      


<210> 3150
<211> 38
<212> PRT
<213> Homo sapiens

<400> 3150
Met Val Val Thr Leu Thr Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly
 1               5                  10                  15      
Leu Glu Asn Lys Thr Val Val Val Thr Thr Ile Leu Glu Ser Pro Tyr
            20                  25                  30          
Val Met Met Lys Lys Asn
        35              


<210> 3151
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3151
Met Val Val Leu Cys Ala Ser Thr Leu Pro Asp Trp Arg Asn Ala Ala
 1               5                  10                  15      
Ala Asp Asn Arg Ser Leu Asp Asp Arg Ser
            20                  25      


<210> 3152
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3152
Met Thr Val Lys Val Asp Gly Val Ala Gln Asp Gly Thr Thr Met Tyr
 1               5                  10                  15      
Ile His Asn Lys Val His Asn Arg Thr Arg Thr
            20                  25          


<210> 3153
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3153
Met Thr Ser Trp Ile Ser Pro Ala Val Asn Asn Ser Asp Phe Trp Thr
 1               5                  10                  15      
Tyr Arg Lys Asn
            20  


<210> 3154
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3154
Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala
 1               5                  10                  15      
Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met
            20                  25                  


<210> 3155
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3155
Met Thr Leu Thr Asn Leu Ser Gly Pro Tyr Ser Tyr Cys Asn Thr Thr
 1               5                  10                  15      
Leu Asp Gln Ile Gly Thr Cys Trp Pro Arg Ser
            20                  25          


<210> 3156
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3156
Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Ile Asp Gly Met
 1               5                  10                  15      
Gly Asn Leu Arg Ile Thr Glu Lys Gly
            20                  25  


<210> 3157
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3157
Met Thr Gly Val Ala Asp Asn Gly Ser Val Leu Glu Ile Thr Pro Asp
 1               5                  10                  15      
Val Ala Glu Val Tyr Leu Val Arg Lys Asn
            20                  25      


<210> 3158
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3158
Met Thr Ala Thr His His Phe Ser Val Asp Leu Asn Ala Ser Arg Ser
 1               5                  10                  15      
Leu Ser Gln Val Ala Met Asp Leu His Glu Ala Val Ser Met Lys Leu
            20                  25                  30          
His Arg Val Arg Glu
        35          


<210> 3159
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3159
Met Ser Gly Thr Leu Val Met Leu Leu Asn Asp Ser Ala Asp Leu Arg
 1               5                  10                  15      
Asp Leu Ala Thr Ser Met Asp Ser Ile Val Lys Leu
            20                  25              


<210> 3160
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3160
Met Arg Pro His Glu Asp Leu Ser Glu Asp Asn Ser Ser Gly Glu Val
 1               5                  10                  15      
Val Met Arg Val Thr Ser Val
            20              


<210> 3161
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3161
Met Gln Thr Cys Gly Asn Val Ser Asn Gln Phe Gln Leu Gly Thr Cys
 1               5                  10                  15      
Arg Leu
        


<210> 3162
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3162
Met Gln Ala Pro Ala Phe Arg Asp Lys Lys Gln Gly Val Ser Ala Lys
 1               5                  10                  15      
Asn Gln Gly Ala His Asp Pro Asp Tyr Glu Asn Ile Thr Leu Ala Phe
            20                  25                  30          
Lys Asn
        


<210> 3163
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3163
Met Pro Arg Pro Asn Gln Thr Ile Leu Val Asp Val Ala Arg Asn
 1               5                  10                  15  


<210> 3164
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3164
Met Asn Asn Val Thr Leu Gly Asn Ala His Met Gly Tyr Tyr Glu Thr
 1               5                  10                  15      
Val Ala Gly Gly Ala Gly Ala Gly Pro Ser Trp His Gly Arg Ser
            20                  25                  30      


<210> 3165
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3165
Met Asn Asn Asn Ser Gly Ala Pro Ala Thr Ala Pro Asp Ser Ala Gly
 1               5                  10                  15      
Gln Pro Pro Ala Leu Gly Pro Val Phe Glu Leu Val Ser Lys Glu
            20                  25                  30      


<210> 3166
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3166
Met Asn Ile Met Ser Thr Leu Gln Trp Ala Val Asn Ser Ser Ile Asp
 1               5                  10                  15      
Val Asp Ser Leu Met Arg Ser Val Ser Arg Val
            20                  25          


<210> 3167
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3167
Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly
 1               5                  10                  15      
Phe Gln Lys Lys
            20  


<210> 3168
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3168
Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile
 1               5                  10                  15      
Pro
    


<210> 3169
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3169
Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu Ile Gly Met
 1               5                  10                  15      
Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys Ile
            20                  25                  30  


<210> 3170
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3170
Met Lys Asn Lys Arg Asn Val Thr Glu Phe Val Leu Thr Gly Leu Thr
 1               5                  10                  15      
Gln Asn Pro Lys Met Glu Lys Val
            20                  


<210> 3171
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3171
Met Ile Tyr Ile Pro Asn Ala Thr Ala Ser Leu Asn Leu Ala Leu Ser
 1               5                  10                  15      
Leu Leu Leu Phe Leu Glu Ile Tyr Asn Glu Arg Val
            20                  25              


<210> 3172
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3172
Met Ile Thr Met Val Cys Cys Ala His Ser Thr Asn Glu Pro Ser Asn
 1               5                  10                  15      
Met Ser Tyr Val Lys Glu
            20          


<210> 3173
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3173
Met Ile Gln Thr Ala His Val Gly Val Gly Ile Ser Gly Asn Glu Gly
 1               5                  10                  15      
Leu Gln Ala Ala Asn Ser Ser Asp Tyr Ser Ile Ala Gln Phe Lys Tyr
            20                  25                  30          


<210> 3174
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3174
Met Ile Asn Phe Ser Ala Phe Leu Gly Ala Ala Thr Met Tyr Thr Arg
 1               5                  10                  15      
Tyr Lys Ile
            


<210> 3175
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3175
Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser Leu Thr Val Ile
 1               5                  10                  15      
Ile Ile Ser Tyr Leu Phe Ile Leu Ile Ala Ile Leu Arg Met Arg Ser
            20                  25                  30          


<210> 3176
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3176
Met Ile His Asn Cys Ser Leu Ile Ala Ser Ala Leu Thr Ile Ser Asn
 1               5                  10                  15      
Ile Gln Ala Gly Ser Thr Gly Asn Trp Gly Cys His Val Gln Thr Lys
            20                  25                  30          
Arg
    


<210> 3177
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3177
Met Ile Phe Asp Phe Tyr Lys Gln Asn Lys Thr Thr Arg Asp
 1               5                  10                  


<210> 3178
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3178
Met His Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met
 1               5                  10                  15      


<210> 3179
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3179
Met Gly Asn Ser Thr Asp Pro Gly Pro Met Leu Ala Ile Pro Ala Met
 1               5                  10                  15      
Ala Thr Asn Pro Gln Asn Ala Ala Ser Arg Arg
            20                  25          


<210> 3180
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3180
Met Gly Asp Val Asn Gln Ser Val Ala Ser Asp Phe Ile Leu
 1               5                  10                  


<210> 3181
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3181
Met Phe Pro Lys Asn Phe Thr Asn Cys Thr Trp Thr Leu Glu Asn Pro
 1               5                  10                  15      
Asp Pro Thr Lys Tyr
            20      


<210> 3182
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3182
Met Phe Cys Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro
 1               5                  10                  15      
Ile His Ser Ser Asn Ser Thr Lys Lys
            20                  25  


<210> 3183
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3183
Met Glu Glu Val Arg Lys Val Asn Glu Ser Ile Lys Tyr
 1               5                  10              


<210> 3184
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3184
Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln
 1               5                  10              


<210> 3185
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3185
Met Asp Leu Thr Leu Asn Ser Ser Thr Ala Thr Pro Val Ser Pro Gly
 1               5                  10                  15      
Ser Val Thr Lys Glu
            20      


<210> 3186
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3186
Met Asp Phe Gly Asp Ser Ser Gly Val Glu Met Arg Leu His Asn Met
 1               5                  10                  15      
Ser Glu Ala Met Ala Val Thr Ala Tyr His Gln Tyr Ser Lys Gly
            20                  25                  30      


<210> 3187
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3187
Met Cys Val Glu Thr Phe Ser Asn Tyr Ser Leu Leu Gly His Phe Ala
 1               5                  10                  15      
Val Arg His
            


<210> 3188
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3188
Met Cys Pro Met Leu Leu Lys Asn Gly Tyr Asn Gly Asn Ala Thr Pro
 1               5                  10                  15      
Val Thr Thr Thr Ala Pro Trp Ala Ser Leu Gly Leu Ser Ala Lys Thr
            20                  25                  30          


<210> 3189
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3189
Met Ala Pro Met Asn Gln Ser Gln Val Leu Met Ser Gly Ser Pro Leu
 1               5                  10                  15      
Glu Leu Asn Ser Leu Gly Glu Glu Gln Arg Ile
            20                  25          


<210> 3190
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3190
Met Ala Ile Leu Phe Asn Asn Met Leu Ser Gly Gln Trp Thr Met Thr
 1               5                  10                  15      
Asn Thr Thr Asn Gln Tyr Ser Ser Leu Met Ile Met Met Ala Met Ala
            20                  25                  30          
Met Lys Leu
        35  


<210> 3191
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3191
Met Ala Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile
 1               5                  10                  15      
Thr Asn Leu Gln Tyr Gly Glu Asp Met Gly His Pro Gly Ser Arg Lys
            20                  25                  30          
Phe
    


<210> 3192
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3192
Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met Asn
 1               5                  10                  15      
Leu Leu Ile Ile Ser Phe Asp Arg Tyr
            20                  25  


<210> 3193
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3193
Leu Thr Ser Leu Ser Val Thr Asn Thr Asn Leu Ser Thr Val Pro Phe
 1               5                  10                  15      
Leu Ala Phe Lys His
            20      


<210> 3194
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3194
Leu Ser Ser Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser
 1               5                  10                  15      
Thr Gly Ser Leu Thr Asn Arg Ser
            20                  


<210> 3195
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3195
Leu Gln Val Glu Gln Gln Leu Ala Asn Ile Thr Val Ser
 1               5                  10              


<210> 3196
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3196
Leu Asn Arg Ile Pro Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp
 1               5                  10                  15      
Thr Gly Asn Leu Arg Ala
            20          


<210> 3197
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3197
Leu Met Asn Ser Ser Gly Leu Trp Val Leu Gly Gly Ser Ile Ala Gln
 1               5                  10                  15      
Gly Phe Arg Ser
            20  


<210> 3198
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3198
Leu Leu Glu Gly Gln Asp Ser Gly Asn Ser Asn Gly Asn Ala Ser Ile
 1               5                  10                  15      
Asn Ile Thr Asp Ile Ser Arg Asn
            20                  


<210> 3199
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3199
Leu Lys Leu Gly Val Val Pro Val Tyr Tyr Gly Ser Pro Ser Ile Thr
 1               5                  10                  15      
Asp Trp Leu Pro Ser Asn Lys Ser Ala Ile Leu Val Ser Glu Phe Ser
            20                  25                  30          
His Pro Arg Glu
        35      


<210> 3200
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3200
Leu Gly Asn Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu
 1               5                  10                  15      
Thr Asn Gly Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn
            20                  25                  30      


<210> 3201
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3201
Leu Gly Leu Asn Leu Ser Glu Gly Asp Gly Glu Glu Val Tyr His Phe
 1               5                  10                  15      


<210> 3202
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3202
Leu Phe Asp Asn Ala Ala Gln Pro Tyr Ser Asn Leu Ser Asn Leu Asp
 1               5                  10                  15      
Val Leu Asn Gln Val Ile Arg Glu Arg Asp Thr Lys Leu
            20                  25                  


<210> 3203
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3203
Leu Glu Glu Asp Ser Val Val His Ser Val Glu Asn Asp Ser Gln Asn
 1               5                  10                  15      
Met Met Glu Ser Leu Ser Pro Lys Lys Tyr
            20                  25      


<210> 3204
<211> 38
<212> PRT
<213> Homo sapiens

<400> 3204
Leu Asp Leu Ser Met Asn Asn Ile Ser Gln Leu Leu Pro Asn Pro Leu
 1               5                  10                  15      
Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg Leu Ala Gly Asn Ala Leu
            20                  25                  30          
Thr Tyr Ile Pro Lys Gly
        35              


<210> 3205
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3205
Leu Asp Cys Pro Ser Ser Ile Ile Gly Met Gly Leu Gly Asn Ala Ser
 1               5                  10                  15      
Thr Gly Tyr Gly Lys Ile
            20          


<210> 3206
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3206
Lys Tyr Asn Val Thr Val Ile Gln Tyr Ile Gly Glu Leu Leu Arg Tyr
 1               5                  10                  15      


<210> 3207
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3207
Lys Tyr Lys Ser Val Tyr Val Gly Glu Glu Thr Asn Ile Thr Leu Asn
 1               5                  10                  15      
Asp Leu Lys Pro Ala Met Asp Tyr His Ala Lys Val Gln Ala Glu Tyr
            20                  25                  30          
Asn Ser Ile Lys Gly
        35          


<210> 3208
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3208
Lys Tyr His Phe Ser Asn Leu Val Ser Pro Thr Asn Leu Ser Gln Phe
 1               5                  10                  15      
Asn Leu Pro Gly Pro Ser Met Met Arg Ser
            20                  25      


<210> 3209
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3209
Lys Tyr Phe Trp Asn Asp Thr Ile His Asn Phe Asp Phe Leu Lys Gly
 1               5                  10                  15      


<210> 3210
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3210
Lys Val Trp Lys Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn
 1               5                  10                  15      
Met Thr Asp Ser Asn Lys Asp
            20              


<210> 3211
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3211
Lys Val Val Asn Pro Gln Glu Tyr Ser Ser Asn Cys Thr Glu Pro Phe
 1               5                  10                  15      
Pro Asn Ser Thr Asn Leu Leu Pro Thr Glu
            20                  25      


<210> 3212
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3212
Lys Val Ser Gln Gln Leu Gly Leu Asp Ala Pro Asn Gly Ser Asp Ser
 1               5                  10                  15      
Ser Pro Gln Ala Pro Pro Pro Arg Arg
            20                  25  


<210> 3213
<211> 44
<212> PRT
<213> Homo sapiens

<400> 3213
Lys Val Ser Leu Gly Ala Val Tyr Phe Phe Met Asn Gly Thr Tyr Gly
 1               5                  10                  15      
Leu Ala Phe Trp Tyr Gly Thr Ser Leu Ile Leu Asn Gly Glu Pro Gly
            20                  25                  30          
Tyr Thr Ile Gly Thr Val Leu Ala Val Lys Arg Lys
        35                  40                  


<210> 3214
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3214
Lys Val Ser Lys Asn Asp Thr Glu Glu Glu Ser Asn Lys Ser
 1               5                  10                  


<210> 3215
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3215
Lys Val Ser Gly Tyr Leu Asn Leu Leu Ala Asn Thr Ile Asp Asn Phe
 1               5                  10                  15      
Thr His Gly Leu Ala Val Ala Ala Ser Phe Leu Val Ser Lys Lys
            20                  25                  30      


<210> 3216
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3216
Lys Val Pro Pro Thr Val Cys Pro Phe His Ser Leu Asn Asn Val Thr
 1               5                  10                  15      
Lys Ala Gly Glu Gly Ser Trp Leu Glu Ser Lys Arg
            20                  25              


<210> 3217
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3217
Lys Val Phe Ile Ser Asn Ser Thr Asn Ser Ser Asn Pro Cys Glu Arg
 1               5                  10                  15      
Arg Ser
        


<210> 3218
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3218
Lys Val Asp Asn Leu Val Val Asn Gly Thr Gly Thr Asn Ser Thr Asn
 1               5                  10                  15      
Ser Thr Thr Ala Val Pro Ser Leu Val Ala Leu Glu Lys Ile
            20                  25                  30  


<210> 3219
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3219
Lys Val Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn
 1               5                  10                  15      
Ser Gln Asn Phe Ala Thr Tyr Lys Glu
            20                  25  


<210> 3220
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3220
Lys Thr Val Arg Thr Thr Glu Glu Ala Pro Ser Ala Pro Pro Gln Ser
 1               5                  10                  15      
Val Thr Val Leu Thr Val Gly Ser Tyr Asn Ser Thr Ser Ile
            20                  25                  30  


<210> 3221
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3221
Lys Thr Ser Ala Thr Ser Val Asn Leu Ser Leu Leu Thr Ala Asp Leu
 1               5                  10                  15      
Tyr Ser Leu Phe Cys Gly Leu Phe Leu Phe
            20                  25      


<210> 3222
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3222
Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu Thr Ala
 1               5                  10                  15      
Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr
            20                  25      


<210> 3223
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3223
Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln
 1               5                  10                  15      


<210> 3224
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3224
Lys Thr Asn Arg Thr Asn Lys Pro Ser Thr Pro Thr Thr Ala Thr Arg
 1               5                  10                  15      
Lys Lys Lys Asp Leu Lys Asn Phe Arg Asn
            20                  25      


<210> 3225
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3225
Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu
 1               5                  10                  15      
Glu Ser Leu Asp Lys Glu His Arg Cys
            20                  25  


<210> 3226
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3226
Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu Ser Ala Glu Asn
 1               5                  10                  15      
Asn Arg Tyr
            


<210> 3227
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3227
Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro Val
 1               5                  10                  15      
Ser Pro Leu Gly Lys Lys Leu
            20              


<210> 3228
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3228
Lys Thr Phe Lys Asn Glu Ser Glu Asn Thr Cys Gln Asp Met Thr Phe
 1               5                  10                  15      
Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser Gln Thr Leu Ser Arg
            20                  25                  30          
Phe
    


<210> 3229
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3229
Lys Ser Val Thr Ile Gln Ala Pro Gly Glu Pro Leu Leu Asp Asn Glu
 1               5                  10                  15      
Ser Thr Arg Gly
            20  


<210> 3230
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3230
Lys Ser Val Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Thr Met
 1               5                  10                  15      
Gly Ala Val Thr Gly Val Asn Ala Asn Val Thr Lys Phe
            20                  25                  


<210> 3231
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3231
Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly Glu Met Gln Thr Leu Glu
 1               5                  10                  15      
Gly Lys Val His Trp Ser Asn Val Asn Glu Ser Glu Pro Ser Phe Glu
            20                  25                  30          
Ala Thr Arg Ser
        35      


<210> 3232
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3232
Lys Ser Pro Met Gln Trp Asp Asn Ser Ser Asn Ala Gly Phe Ser Glu
 1               5                  10                  15      
Ala Ser Asn Thr Trp Leu Pro Thr Asn Ser Asp Tyr His Thr Val Asn
            20                  25                  30          
Val Asp Val Gln
        35      


<210> 3233
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3233
Lys Ser Lys Glu Gln Asn Val Ser Asp Asp Pro Glu Ser Thr Gly Phe
 1               5                  10                  15      
Leu Tyr Pro Tyr Asn Asp Leu Leu Val Trp Ala Val Leu Met Lys Arg
            20                  25                  30          
Gln
    


<210> 3234
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3234
Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr Leu Ser Tyr Arg
 1               5                  10                  15      
Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys
            20                  25          


<210> 3235
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3235
Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr
 1               5                  10                  15      
Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser
            20                  25              


<210> 3236
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3236
Lys Arg Tyr Asn Gly Ser Asp Pro Ala Ser Gly Pro Ser Val Gln Asp
 1               5                  10                  15      
Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val
            20                  25                  30          
Gly
    


<210> 3237
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3237
Lys Arg Gln Pro Ala Thr Leu Thr Val Asp Trp Phe Asn Ala Thr Ser
 1               5                  10                  15      
Ser Lys Val Asn Ala Thr Phe Ser Glu Ala Ser Pro Val Glu Leu Lys
            20                  25                  30          
Leu
    


<210> 3238
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3238
Lys Arg Asn Glu Thr Leu Val Phe Ser His Asn Ala Val Ile Ala Met
 1               5                  10                  15      
Arg Asp
        


<210> 3239
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3239
Lys Arg Leu Val Ser Met Asn Met Pro Leu Asn Ser Asp Gly Thr Val
 1               5                  10                  15      
Met Phe Asn Ala Thr Leu Phe Ala Leu Val Arg Thr Ala Leu Arg Ile
            20                  25                  30          
Lys Thr
        


<210> 3240
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3240
Lys Arg Lys Glu Ala Glu Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser
 1               5                  10                  15      
Leu Trp Asp Arg Leu
            20      


<210> 3241
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3241
Lys Arg Gly Arg Gly Asn Phe Gly Gly Gln Ser Glu Gln Glu Asn Thr
 1               5                  10                  15      
Leu Asn Gln Leu Leu Val Glu Met Asp Gly Phe Asn Thr Thr
            20                  25                  30  


<210> 3242
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3242
Lys Arg Gly Asn Thr Thr Leu Glu Ser Thr Asp Thr
 1               5                  10          


<210> 3243
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3243
Lys Gln Thr Glu Ser Ser Phe Met Ala Gly Asp Ile Asn Ser Thr Pro
 1               5                  10                  15      
Thr Leu Asn Arg Gly
            20      


<210> 3244
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3244
Lys Gln Thr Asp Val Ile Asn Ala Ser Trp Trp Val Met Ser Asn Lys
 1               5                  10                  15      
Thr Arg Asp Glu Leu Glu Arg Ser
            20                  


<210> 3245
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3245
Lys Gln Ser Glu Ser Ser Phe Ile Thr Gly Asp Ile Asn Ser Ser Ala
 1               5                  10                  15      
Ser Leu Asn Arg Glu Gly Leu Leu Asn
            20                  25  


<210> 3246
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3246
Lys Gln Arg Met Glu Pro Leu Tyr Ser Leu Asn Val Ser Val Ser Asp
 1               5                  10                  15      
Gly Leu Phe Thr Ser Thr Ala Gln Val His Ile Arg Val
            20                  25                  


<210> 3247
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3247
Lys Gln Pro Ser Ser Pro Leu Ala Asn Thr Thr Tyr Asn Ile Phe Ile
 1               5                  10                  15      
Met Asp Gly Lys Thr
            20      


<210> 3248
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3248
Lys Gln Asn Ser Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala
 1               5                  10                  15      
Ile Asp Ser Gly Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser
            20                  25                  30  


<210> 3249
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3249
Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn
 1               5                  10                  15      
Cys Ser Pro Asn Arg Gln Lys Pro
            20                  


<210> 3250
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3250
Lys Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile
 1               5                  10                  


<210> 3251
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3251
Lys Asn Asn Gly Phe Phe Gln Lys Leu Asn Val Thr Glu Gly Ala Met
 1               5                  10                  15      
Gln Asp Leu Leu Lys Glu Ile Ile Lys Val
            20                  25      


<210> 3252
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3252
Lys Asn Asn Tyr Ser Pro Thr Ala Ala Gly Thr Glu Arg Arg Lys
 1               5                  10                  15  


<210> 3253
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3253
Lys Asn Met Ala Leu Phe Glu Glu Glu Met Asp Thr Ser Pro Met Val
 1               5                  10                  15      
Ser Ser Leu Leu Ser Gly Leu Ala Asn Tyr Thr Asn Leu Pro Gln Gly
            20                  25                  30          
Ser Arg Glu
        35  


<210> 3254
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3254
Lys Asn Leu Asp Leu Ile Leu Pro Thr Leu Arg Asn Tyr Thr Val Ile
 1               5                  10                  15      
Asn Ser Lys Ile Ile Val Val Thr Ile Arg Pro
            20                  25          


<210> 3255
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3255
Lys Asn Ile Gly Asp Asp Gly Gly Gly Asp Asp Asn Thr Phe Asn Phe
 1               5                  10                  15      
Ser Trp Lys Val
            20  


<210> 3256
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3256
Lys Asn Gly Arg Tyr Gln Pro Ser Ile Pro Pro His Ala Ala Val Ala
 1               5                  10                  15      
Ala Asn Gln Ser Arg Ala Arg Arg Gly
            20                  25  


<210> 3257
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3257
Lys Asn Trp Thr Ala Ala Leu Phe Thr Gly Asn Leu Leu Leu Ala Arg
 1               5                  10                  15      
Asp
    


<210> 3258
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3258
Lys Asn Trp Ser Ala Leu Leu Thr Ala Val Val Ile Ile Leu Thr Ile
 1               5                  10                  15      
Ala Gly Asn Ile Leu Val Ile Met Ala Val Ser Leu Glu Lys Lys Leu
            20                  25                  30          


<210> 3259
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3259
Lys Asn Ser Thr Phe Thr Tyr Phe Thr Ser Asp His Gly Gly His Leu
 1               5                  10                  15      
Glu Ala Arg Asp Gly His Ser Gln Leu Gly Gly Trp Asn Gly Ile Tyr
            20                  25                  30          
Lys Gly
        


<210> 3260
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3260
Lys Asn Leu Ser Glu Met Gln Asp Leu Glu Glu Ile Arg Lys Ile Thr
 1               5                  10                  15      
Gly Val Cys Pro Gln Phe Asn Val Gln Phe Asp
            20                  25          


<210> 3261
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3261
Lys Asn Lys Thr Thr Cys Leu Arg Gly Ser Asp Thr Ala Ala Leu Val
 1               5                  10                  15      
Pro Val Pro Leu Ala Thr Pro Leu Leu Leu Glu Gly Arg Ser
            20                  25                  30  


<210> 3262
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3262
Lys Asn Ile Ser Asn Pro Glu Ala Tyr Asp His Cys Phe Glu Lys Lys
 1               5                  10                  15      
Glu
    


<210> 3263
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3263
Lys Asn Gly Thr Ile Phe Thr Ile Ser Pro Val Leu Leu Leu Asp Thr
 1               5                  10                  15      
Ile Ser Thr Thr Arg Phe
            20          


<210> 3264
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3264
Lys Asn Gly Ser Gly Asn Ala Ile Ile Ile Val Val Gly Gly Ala Ala
 1               5                  10                  15      
Glu Ser Leu Ser Ser Met Pro Gly Lys Asn
            20                  25      


<210> 3265
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3265
Lys Met Ser His Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly
 1               5                  10                  15      
Thr Ser Asn Thr Thr Ser Val Ser Val Lys
            20                  25      


<210> 3266
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3266
Lys Met Pro Gly Asp Ile Lys Asn Trp Val Asp Ala His Met Asn Cys
 1               5                  10                  15      
Glu Asp Ile Ala Met Asn Phe Leu Val Ala Asn Val Thr Gly Lys Ala
            20                  25                  30          


<210> 3267
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3267
Lys Met Asn Glu Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu Cys
 1               5                  10                  15      
Ile Asp Val Glu Asp Ala Met Asn Ile Thr Arg Lys
            20                  25              


<210> 3268
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3268
Lys Met Asn Cys Asn Asn Arg Asn Val Ser Ser Leu Ala Asp Leu Lys
 1               5                  10                  15      
Pro Lys Leu
            


<210> 3269
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3269
Lys Met Leu Met Gly Ile Asn Val Thr Pro Ile Ala Ala Leu Leu Tyr
 1               5                  10                  15      
Thr Pro Val Leu Ile Arg Phe
            20              


<210> 3270
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3270
Lys Met Ala Ala Val Thr Leu Leu Ala Leu Ala Tyr Thr Gln Gly Pro
 1               5                  10                  15      
Val Leu Phe Asn Leu Thr Phe Lys Ile
            20                  25  


<210> 3271
<211> 39
<212> PRT
<213> Homo sapiens

<400> 3271
Lys Leu Val Pro Ser Ser Ser Tyr Val Ala Val Ala Pro Val Lys Ser
 1               5                  10                  15      
Ser Pro Thr Thr Ser Val Pro Ala Val Ser Ser Pro Pro Met Gly Asn
            20                  25                  30          
Gln Ser Gly Gln Ser Val Pro
        35                  


<210> 3272
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3272
Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys
 1               5                  10                  15      
Leu
    


<210> 3273
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3273
Lys Leu Arg Glu Gln Val Asn Ser Met Val Asp Ile Ser Lys Met His
 1               5                  10                  15      
Met Ile Leu Tyr Asp Leu Gln Gln Asn Leu Ser Ser Ser His Arg Ala
            20                  25                  30          


<210> 3274
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3274
Lys Leu Gln Asn Ala Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp
 1               5                  10                  15      
Ile Glu Glu Ala Gln Arg Ser
            20              


<210> 3275
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3275
Lys Leu Asn Gln Leu Tyr Asn Cys Ser Ser Ser Leu Ser Phe Met Asp
 1               5                  10                  15      
Ser Cys
        


<210> 3276
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3276
Lys Leu Asn Asn Thr Met Asn Ala Cys Ala Ala Ile Ala Ala Leu Glu
 1               5                  10                  15      
Arg Val Lys Ile
            20  


<210> 3277
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3277
Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu
 1               5                  10              


<210> 3278
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3278
Lys Leu Met Ile Ser Ser Tyr Ser Gly Ser Val Asp Ile Val Asn Thr
 1               5                  10                  15      
Thr Asp Gly Cys His Glu
            20          


<210> 3279
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3279
Lys Leu Leu Tyr Leu Thr Thr Thr Asn Glu Ser Gly Val Phe Ile Thr
 1               5                  10                  15      
Gly His
        


<210> 3280
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3280
Lys Leu Leu Leu Ile Arg Ala Gly Lys Leu Leu Val Ile Asn His Ser
 1               5                  10                  15      
Ser Pro Leu Pro Gly Asp
            20          


<210> 3281
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3281
Lys Leu Lys Thr Asn Val Thr Phe Pro Leu Asp Ile Leu Leu Leu Ser
 1               5                  10                  15      
Phe Lys Ala
            


<210> 3282
<211> 38
<212> PRT
<213> Homo sapiens

<400> 3282
Lys Leu His Cys Asn Ser Ala Cys Leu Thr Asn Thr Thr His Cys Pro
 1               5                  10                  15      
Glu Glu Ala Ser Val Gly Asn Pro Glu Gly Ala Phe Met Lys Val Leu
            20                  25                  30          
Gln Ala Arg Lys Asn Tyr
        35              


<210> 3283
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3283
Lys Leu Gly Val Ser Ser Val Pro Ser Cys Tyr Leu Ile Tyr Pro Asn
 1               5                  10                  15      
Gly Ser His Gly Leu Ile Asn Val Val Lys Pro Leu Arg Ala
            20                  25                  30  


<210> 3284
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3284
Lys Leu Glu Asn Ser Lys Asn Gly Thr Ala Gly Leu Ile Pro Ser Pro
 1               5                  10                  15      
Glu Leu Gln Glu Trp Arg Val
            20              


<210> 3285
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3285
Lys Lys Val Leu Val Ala Pro Pro Pro Asp Glu Glu Ala Asn Ala Thr
 1               5                  10                  15      
Ser Ala Val Val Ser Leu Leu Asn Glu Thr Val Thr Glu Val Pro Glu
            20                  25                  30          
Glu Thr Lys Met
        35      


<210> 3286
<211> 45
<212> PRT
<213> Homo sapiens

<400> 3286
Lys Lys Gln Pro Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser
 1               5                  10                  15      
Gly Ala Ala Ala Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala
            20                  25                  30          
Ala Ala Ile Ala Ser Thr Thr Ile Met Val Pro Phe Gly
        35                  40                  45  


<210> 3287
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3287
Lys Lys Gln Asn Asp Ser Val Ile Ala Glu Cys Ser Asn Arg Arg Leu
 1               5                  10                  15      


<210> 3288
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3288
Lys Lys Asn Ser Asp Gly Met Glu Ala Ala Gly Val Gln Ile Gln Met
 1               5                  10                  15      
Val Asn Glu Ser Leu Gly Tyr
            20              


<210> 3289
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3289
Lys Lys Asn Asn Leu Pro Phe Leu Thr Asn Val Thr Leu Pro Arg Ser
 1               5                  10                  15      


<210> 3290
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3290
Lys Lys Asn Lys Asn Ser Ser Lys Pro Gln Lys Asn Asn Gly Ser Thr
 1               5                  10                  15      
Trp Ala Asn Val Pro Leu Pro Pro Pro Pro Val
            20                  25          


<210> 3291
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3291
Lys Lys Glu Ile Tyr Met His Thr Gly Asn Ser Ser Thr Pro Arg Gly
 1               5                  10                  15      
Glu Gly Gly Ser Cys Tyr
            20          


<210> 3292
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3292
Lys Lys Asp Leu Ser Cys Ser Asn Phe Ser Leu Leu Ala Tyr Gln Phe
 1               5                  10                  15      
Asp His Phe Ser His Glu Lys Ile Lys Asp
            20                  25      


<210> 3293
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3293
Lys Lys Ala Ala Asp Thr Ala Val Gly Trp Ala Leu Gly Tyr Met Leu
 1               5                  10                  15      
Asn Leu Thr Asn Leu Ile Pro Ala Asp Pro Pro Gly Leu Arg Lys
            20                  25                  30      


<210> 3294
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3294
Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys Met Ser Ser Gln Thr
 1               5                  10                  15      
Lys Asn
        


<210> 3295
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3295
Lys Ile Asn Asn Ser Thr Asn Glu Gly Met Asn Val Lys Lys
 1               5                  10                  


<210> 3296
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3296
Lys Ile Lys Leu Arg Ser Ala Met Tyr Leu Ser Asn Thr Thr Val Thr
 1               5                  10                  15      
Ile Leu Ala Asn Leu Val Pro Phe Thr Leu Thr
            20                  25          


<210> 3297
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3297
Lys Ile Ile Leu Asn Ala Leu Val Ala Gln Gln Lys Asn Gly Ser Pro
 1               5                  10                  15      
Ala Gly Gly Asp Ala Lys Glu Leu Asp Ser Lys Ser Lys Gly
            20                  25                  30  


<210> 3298
<211> 39
<212> PRT
<213> Homo sapiens

<400> 3298
Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala Met Thr
 1               5                  10                  15      
Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp Ile Gly
            20                  25                  30          
Val Ala Met Gly Gln Thr Gly
        35                  


<210> 3299
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3299
Lys Ile His Gln Gly Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu
 1               5                  10                  15      
Leu Gly Tyr Tyr Gln Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val
            20                  25                  30          
Ser Gly
        


<210> 3300
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3300
Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn Leu Ser Ser Leu
 1               5                  10                  15      
Val Val Leu His Leu His Asn Asn Arg Ile His Ser Leu Gly Lys Lys
            20                  25                  30          


<210> 3301
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3301
Lys Ile Phe Gln Ile Tyr Lys Gly Asn Phe Thr Gly Ser Val Glu Pro
 1               5                  10                  15      
Glu Pro Ser Thr Leu Thr Pro Arg Thr
            20                  25  


<210> 3302
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3302
Lys Ile Glu Asn Tyr Ile Asn Glu Ser Thr Glu Ala Gln Ser Glu Gln
 1               5                  10                  15      
Lys Glu
        


<210> 3303
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3303
Lys Ile Ala Arg Leu Gly Asn Gly Ser Gln Asp Leu Asn His Gly Val
 1               5                  10                  15      
Asp Asn Glu Asn Gly Gly Arg Arg Gly Pro Asn Arg Thr
            20                  25                  


<210> 3304
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3304
Lys His Gln Val Glu Ala Leu Lys Asn Met Gln His Gln Asn Gln Ser
 1               5                  10                  15      
Leu Ser Met Leu Asp Glu Ile Leu Glu Asp Val Arg Lys Ala
            20                  25                  30  


<210> 3305
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3305
Lys His Pro Met Ala Asn Ile Thr Trp Met Ala Asn His Thr Gly Trp
 1               5                  10                  15      
Ser Asp Phe Ile Leu Leu Gly Leu Phe Arg Gln
            20                  25          


<210> 3306
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3306
Lys His Ala Ala Phe Phe Ala Asp Ala Glu Gly Tyr Phe Ala Ala Cys
 1               5                  10                  15      
Thr Thr Asp Thr Thr Met Asn Ser Ser Leu Ser Glu Pro Leu Tyr Val
            20                  25                  30          
Pro Val Lys Phe
        35      


<210> 3307
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3307
Lys Gly Thr Asn Val Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala
 1               5                  10                  15      
Trp Asn Arg Val
            20  


<210> 3308
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3308
Lys Gly Thr Gly Ser Trp Thr Gln Leu Tyr Leu Ile Thr Asp Tyr His
 1               5                  10                  15      
Glu Asn Gly Ser Leu Tyr Asp Tyr Leu Lys Ser
            20                  25          


<210> 3309
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3309
Lys Gly Pro Ile Gly Pro Gly Glu Pro Leu Glu Leu Leu Cys Asn Val
 1               5                  10                  15      
Ser Gly Ala Leu Pro Pro Ala Gly Arg His
            20                  25      


<210> 3310
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3310
Lys Gly Pro Gly Glu Val Ile Pro Gly Gly Asn His Ser Leu Tyr Ser
 1               5                  10                  15      
Leu Lys Gly
            


<210> 3311
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3311
Lys Gly Leu Tyr Gln Gly Phe Asn Met Ser Val Gln Gly Ile Ile Ile
 1               5                  10                  15      
Tyr Arg Ala
            


<210> 3312
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3312
Lys Gly Lys Pro Val Asn Met Thr Lys Ala Thr Val Asn Tyr Arg Gln
 1               5                  10                  15      
Glu Lys
        


<210> 3313
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3313
Lys Gly Ile Leu Tyr Gly Thr Met Thr Leu Glu Leu Gly Gly Thr Val
 1               5                  10                  15      
Asn Ile Thr Cys Gln Lys Thr
            20              


<210> 3314
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3314
Lys Gly Ile Ala Ile Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro
 1               5                  10                  15      
Phe Ile Tyr Thr Leu Arg Asn
            20              


<210> 3315
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3315
Lys Phe Ser Ile Ala Ile Leu Pro Phe Ser Ile Lys Ala Met Ala Glu
 1               5                  10                  15      
Ala Asn Val Ser Leu Arg Arg Met Lys Lys
            20                  25      


<210> 3316
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 7, 14, 16
<223> Xaa = Any Amino Acid

<400> 3316
Lys Phe Asn Thr Thr Glu Xaa Val Leu Gln Gly Leu Leu Xaa Pro Xaa
 1               5                  10                  15      
Phe
    


<210> 3317
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3317
Lys Phe Asn Pro Ser Leu Asn Val Val Asp Lys Ile
 1               5                  10          


<210> 3318
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3318
Lys Phe Leu Ala Leu Val Thr Met Asn Gln Ser Gly Trp Gly Thr Ser
 1               5                  10                  15      
Gly Arg Arg
            


<210> 3319
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3319
Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr Asn Val
 1               5                  10                  15      
Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Asn
            20                  25                  30          
Ser
    


<210> 3320
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3320
Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile Tyr Val Ile Thr
 1               5                  10                  15      
Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe
            20                  25                  


<210> 3321
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3321
Lys Glu Tyr Val Lys Ser Glu Val Ile Lys Leu Leu Pro Asn Ala Asn
 1               5                  10                  15      
Gly Ser Asn Val Gln Leu Gln Leu Lys Phe
            20                  25      


<210> 3322
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3322
Lys Glu Val Asn Ser Ser Leu His Leu Gly His Ala Gly Ser Ser Pro
 1               5                  10                  15      
His Ala Leu Ala Ser
            20      


<210> 3323
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3323
Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser
 1               5                  10                  15      
Val His Val Lys Pro Glu Asn Leu Arg Leu
            20                  25      


<210> 3324
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3324
Lys Glu Asn Ile Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn
 1               5                  10                  15      
Ile Trp Lys Thr Gly Pro Leu Phe Lys Arg
            20                  25      


<210> 3325
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3325
Lys Glu Asn Glu Thr Glu Ser Leu Gln Ile Leu Asn Ala Lys Thr
 1               5                  10                  15  


<210> 3326
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3326
Lys Glu Leu Gln Glu Gly Asn Glu Thr Asp Glu Ala Lys Thr
 1               5                  10                  


<210> 3327
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3327
Lys Glu Lys Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu
 1               5                  10                  15      
Leu Gln Pro Leu Leu Glu Gly Glu Val Lys Gly
            20                  25          


<210> 3328
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3328
Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln
 1               5                  10              


<210> 3329
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3329
Lys Glu Gly Leu Leu Ala Asn Thr Met Ser Lys Met Tyr Gly His Glu
 1               5                  10                  15      
Asn Gly Asn Ser Ser Ser Pro Ser Pro Glu Glu Lys Gly
            20                  25                  


<210> 3330
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3330
Lys Glu Phe Ala Glu Phe Leu Ser Lys Glu Ala Leu Asn Ala Ser Ala
 1               5                  10                  15      
Asp Gln Phe Val Thr Gln Lys Arg
            20                  


<210> 3331
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3331
Lys Asp Arg Ile Ala Thr Ile Asn Tyr Thr Val Leu Thr Ser Val Leu
 1               5                  10                  15      
Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp
            20                  25          


<210> 3332
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3332
Lys Asp Met Val Val Met Leu Leu Ser Met Leu Glu Gly Asn Val Val
 1               5                  10                  15      
Asn Gly Thr Ile Gly Lys Gln
            20              


<210> 3333
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3333
Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro Gly Phe Phe Phe
 1               5                  10                  15      
Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln
            20                  25          


<210> 3334
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3334
Lys Asp Asp Trp Ile Arg Pro Ala Leu Leu Ser Gly Pro Val Ala Ala
 1               5                  10                  15      
Asn Val Leu Asn Phe Ser Asp His His Val Ile Pro Met Pro Leu Leu
            20                  25                  30          
Lys Gly
        


<210> 3335
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3335
Lys Cys Val Pro Val Thr Leu Trp His Leu Gly Tyr Trp Leu Cys Tyr
 1               5                  10                  15      
Val Asn Ser Thr Val Asn Pro Ile Cys Tyr Ala Leu Cys Asn Arg Thr
            20                  25                  30          


<210> 3336
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3336
Lys Cys Thr Asn Leu Ser Glu Gly Val Leu Ser Val Arg Lys Arg
 1               5                  10                  15  


<210> 3337
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3337
Lys Cys Pro Gly Pro Thr Ser Gly Pro Ser Pro Gly Thr Asn Leu Ser
 1               5                  10                  15      
Gly Cys Ile Arg Met
            20      


<210> 3338
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3338
Lys Cys Glu Cys Val Ala Pro Asp Thr Val Asn Thr Thr Val Phe Asn
 1               5                  10                  15      
Ala Ser Ala Pro Leu Ala Pro Asp Thr
            20                  25  


<210> 3339
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3339
Lys Cys Ala Pro Glu Ser Glu Pro Ser Asn Ser Thr Glu Gly Glu Thr
 1               5                  10                  15      
Pro Cys
        


<210> 3340
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3340
Lys Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser
 1               5                  10      


<210> 3341
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3341
Lys Ala Thr Phe Val Lys Val Val Pro Thr Pro Asn Asn Gly Ser Thr
 1               5                  10                  15      
Glu Leu Val Ala Leu His Arg Asn
            20                  


<210> 3342
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3342
Lys Ala Ser Leu Cys Leu Pro Thr Thr Ser Ala Pro Ala Ser Ala Pro
 1               5                  10                  15      
Ser Asn Gly Asn Cys Ser Ser
            20              


<210> 3343
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3343
Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr
 1               5                  10                  15      
Tyr Arg
        


<210> 3344
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3344
Lys Ala Ala Ile Gln Gly Asn Gly Asp Val Gly Ala Ala Ala Ala Thr
 1               5                  10                  15      
Ala His Asn Gly Phe Ser Cys Ser Asn Cys Ser Met Leu Ser Glu Arg
            20                  25                  30          
Lys
    


<210> 3345
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3345
Ile Ser Asn Pro Leu His Cys Asn Met Thr Met Thr Pro Gly Thr Cys
 1               5                  10                  15      
Arg Val
        


<210> 3346
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3346
Ile Leu Gly Lys Asn Glu Glu Ala Asn Val Thr Ile Pro Leu Gln Gly
 1               5                  10                  15      
Phe Pro Arg Lys Glu
            20      


<210> 3347
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3347
Ile Leu Glu Ser Leu Met Cys Asn Glu Ser Ser Met Gln Ser Leu Arg
 1               5                  10                  15      
Gln Arg Lys
            


<210> 3348
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3348
Ile Phe Lys Asn Ala Thr Phe Thr Phe Thr Trp Ala Phe Gln Arg Thr
 1               5                  10                  15      


<210> 3349
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3349
Ile Glu Arg Ile Leu Asn Ser Val Gly Ser Arg Met Gly Ser Thr Asp
 1               5                  10                  15      
Ser Leu Asn Lys Thr
            20      


<210> 3350
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3350
Ile Asp Asn Thr Thr Asn Ser Met Lys Lys Thr Lys Ser
 1               5                  10              


<210> 3351
<211> 38
<212> PRT
<213> Homo sapiens

<400> 3351
His Ser Phe Leu Val His Leu Ile Gly Leu Leu Val Trp Gln Cys Asp
 1               5                  10                  15      
Ile Ser Val Ser Pro Val Ala Ala Ile Val Thr Asp Ile Phe Asn Thr
            20                  25                  30          
Ser Asp Gly Gly Arg Phe
        35              


<210> 3352
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3352
His Asp Val Thr Asn Ile Ser Thr Pro Thr His Val Val Phe Ser Ser
 1               5                  10                  15      
Ser Thr Ala Ser Thr Thr Val Gly Phe Glu Trp
            20                  25          


<210> 3353
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3353
Gly Leu Glu Ala Val Val Ile Gly Glu Val His Glu Asn Val Thr Leu
 1               5                  10                  15      
His Cys Gly Asn Ile Ser Gly Leu Arg Gly
            20                  25      


<210> 3354
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3354
Gly Ile Asp Thr Thr Ser Leu His Ser His Asn Gly Ser Pro Leu Thr
 1               5                  10                  15      
Ser Lys Asn
            


<210> 3355
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3355
Gly Asp Gln Leu Ser Asn Leu Ser Asn Leu Leu Gln Gln Tyr Lys Thr
 1               5                  10                  15      


<210> 3356
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3356
Gly Ala Ala Ser Tyr Phe Leu Ile Leu Asp Ser Thr Asn Thr Val Pro
 1               5                  10                  15      
Asp Ser Ala Gly Ser Gly Asn Val Thr Arg Cys
            20                  25          


<210> 3357
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3357
Phe Asn Gln Ile Met His Ala Phe Ser Val Ala Pro Phe Asp Gln Asn
 1               5                  10                  15      
Leu Ser Ile Asp Gly Lys Ile
            20              


<210> 3358
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3358
Phe His Gly Leu Tyr Glu Glu Lys Asn Leu Ser Pro Gly Phe Asn Phe
 1               5                  10                  15      
Arg Phe
        


<210> 3359
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3359
Phe Phe Leu Thr Thr Pro Ala Ile Ile Met Asn Thr Ile Asp Met Tyr
 1               5                  10                  15      
Asn Val Thr Arg Pro Ile Glu Lys Leu
            20                  25  


<210> 3360
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3360
Glu Gln Leu Asn Gln Thr Leu Ala Glu Met Lys Ala Gln Glu Val Ala
 1               5                  10                  15      
Glu Leu Lys Arg Lys Lys
            20          


<210> 3361
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3361
Glu Asn Ile Thr Ile Val Asp Ile Ser Arg Lys
 1               5                  10      


<210> 3362
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3362
Glu Asn Cys Thr Lys Ile Phe Glu Lys Asn
 1               5                  10  


<210> 3363
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3363
Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser Thr Thr Pro
 1               5                  10                  15      
Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr Leu Asp Gln
            20                  25                  30          
Ser Lys Ala
        35  


<210> 3364
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3364
Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val
 1               5                  10                  15      
Arg Arg
        


<210> 3365
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3365
Glu Asp Gly Leu Tyr Gly Ala Pro Glu Pro Asn Gly Ser Trp Thr Gly
 1               5                  10                  15      
Met Val Gly Glu Leu Ile Asn Arg Lys
            20                  25  


<210> 3366
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3366
Asp Tyr Asn Val Gln Thr Ser Asn Trp Thr Arg Thr
 1               5                  10          


<210> 3367
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3367
Asp Val Asn Leu Ser Lys Thr Glu Lys Met Gly Asn Thr Val Glu Ser
 1               5                  10                  15      
Glu His Leu Ser Glu Leu Thr Glu Glu Glu Tyr Glu Ala His Tyr Ile
            20                  25                  30          
Arg Arg
        


<210> 3368
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3368
Asp Ser Ser Pro Glu His Asn Leu Thr Lys Ile Ala Asn Gly Val Pro
 1               5                  10                  15      
Asn Ser Lys Gly
            20  


<210> 3369
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3369
Asp Met Val Val Met Leu Leu Ser Leu Leu Glu Gly Asn Val Val Asn
 1               5                  10                  15      
Gly Thr Ile Gly Lys Gln
            20          


<210> 3370
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3370
Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg
 1               5                  10                  15      
Leu Leu Asp Gly Tyr Asp Asn Arg Leu
            20                  25  


<210> 3371
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3371
Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro Asn
 1               5                  10                  15      
Leu Glu Leu Glu Ala Leu Phe Lys Arg
            20                  25  


<210> 3372
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3372
Cys Thr Ala Asp Asn Ser Tyr Gly Pro Val Gln Ser Met Val Leu Asn
 1               5                  10                  15      
Val Thr Val Arg Glu
            20      


<210> 3373
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3373
Cys Asp Lys Tyr Asn Ala Gln Pro Val Gly Asn Trp Ser Asp Cys Ile
 1               5                  10                  15      
Leu Pro Glu Gly Lys Val
            20          


<210> 3374
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3374
Ala Val Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Ser Gly Gln
 1               5                  10                  15      
Ala Ala Ala Asn Trp Leu Ala Gly Phe Gly Arg Gly
            20                  25              


<210> 3375
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3375
Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr
 1               5                  10                  15      
Tyr Ile Cys Met Gln Arg Thr
            20              


<210> 3376
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3376
Ala Ser Gly Pro Val Ile Leu Ser Glu Leu His Pro Ile Cys Asn Lys
 1               5                  10                  15      
Ser Ile Leu Arg Gln
            20      


<210> 3377
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3377
Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser Tyr Arg Arg
 1               5                  10                  


<210> 3378
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3378
Ala Met Asn Glu Pro Gln Cys Phe Tyr Asn Glu Ser Ile Ala Phe Phe
 1               5                  10                  15      
Tyr Asn Arg Ser
            20  


<210> 3379
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3379
Ala His Asn His His Gly Glu Asn Lys Thr Val Leu Arg Lys
 1               5                  10                  


<210> 3380
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3380
Ala Phe Asn Cys Pro Pro Asn Ser Thr Met Asn Arg Gly
 1               5                  10              


<210> 3381
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3381
Ala Glu Asn Arg Asn Pro Ser Cys Glu Val His Gln Glu Pro Val Thr
 1               5                  10                  15      
Tyr Thr Ala Ile Asp Pro Gly Leu Gln Asp Ala Leu His Gln Cys Val
            20                  25                  30          
Asn Ser Arg Cys
        35      


<210> 3382
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3382
Ala Asp Gly Ala Ala Ala Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser
 1               5                  10                  15      
Leu Val Asn Ala Lys Gln
            20          


<210> 3383
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3383
Asn Asn Phe Ser Thr Glu Ile Asn Thr Thr Ser Ile Leu Val Gly Pro
 1               5                  10                  15      


<210> 3384
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3384
Met Val Leu Ala Ser Gly Asn Ser Ser Ser His Pro Val Ser Phe Ile
 1               5                  10                  15      
Leu Leu Gly Ile Pro Gly Leu Glu Ser Phe Gln
            20                  25          


<210> 3385
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3385
Met Thr Leu Val Ser Phe Phe Ser Phe Leu Ser Lys Pro Leu Ile Met
 1               5                  10                  15      
Leu Leu Ser Asn Ser Ser Trp Arg Leu
            20                  25  


<210> 3386
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3386
Met Ser Tyr Gln Leu Tyr Asn Tyr Pro Asn Lys Thr Leu Leu Phe Ser
 1               5                  10                  15      
Lys His
        


<210> 3387
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3387
Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg
 1               5                  10                  15      
Arg
    


<210> 3388
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3388
Met Ser Ser Lys Pro Glu Pro Lys Asp Val His Gln Leu Asn Gly Thr
 1               5                  10                  15      
Gly Pro Ser Ala Ser Pro Cys Ser Ser Asp Gly Pro Gly Arg Glu
            20                  25                  30      


<210> 3389
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3389
Met Ser Asn Asn Ser Pro Glu Tyr Ala Leu Val Phe Thr Ile Ser Gly
 1               5                  10                  15      
Ala Met Ala
            


<210> 3390
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3390
Met Ser Phe Leu Asn Gly Thr Ser Leu Thr Pro Ala Ser Phe Ile Leu
 1               5                  10                  15      
Asn Gly Ile Pro Gly Leu Glu Asp
            20                  


<210> 3391
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3391
Met Ser Ala Gly Asn Gly Thr Pro Trp Gly Ser Ala Ala Gly Glu Glu
 1               5                  10                  15      
Val Trp Ala Gly
            20  


<210> 3392
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3392
Met Arg Gln Asn Asn Asn Ile Thr Glu Phe Val Leu Leu Gly Phe Ser
 1               5                  10                  15      
Gln Asp Leu Asp Val Gln Lys Ala
            20                  


<210> 3393
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3393
Met Asn Leu Asp Ser Phe Phe Ser Phe Leu Leu Lys Ser Leu Ile Met
 1               5                  10                  15      
Ala Leu Ser Asn Ser Ser Trp Arg Leu
            20                  25  


<210> 3394
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3394
Met Asn Val Ser Gly Cys Pro Gly Ala Gly Asn Ala Ser Gln Ala Gly
 1               5                  10                  15      
Gly Gly Gly Gly
            20  


<210> 3395
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3395
Met His Arg Leu Met Gly Val Asn Ser Thr Ala Ala Ala Ala
 1               5                  10                  


<210> 3396
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3396
Met Gly Leu Asn Thr Ser Ala Ser Thr Phe Gln Leu Thr Gly Phe Pro
 1               5                  10                  15      
Gly Met Glu Lys Ala
            20      


<210> 3397
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3397
Met Phe Pro Asn Gly Thr Ala Ser Ser Pro Ser Ser Ser Pro Ser Pro
 1               5                  10                  15      
Ser Pro Gly Ser Cys Gly Glu Gly Gly Gly Ser Arg
            20                  25              


<210> 3398
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3398
Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys
 1               5                  10                  15      
Lys
    


<210> 3399
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3399
Met Asp Gly Asp Asn Gln Ser Glu Asn Ser Gln Phe Leu Leu Leu Gly
 1               5                  10                  15      
Ile Ser Glu Ser Pro Glu Gln Gln Arg Ile
            20                  25      


<210> 3400
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3400
Arg Val Leu Pro Val Asn Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr
 1               5                  10                  15      


<210> 3401
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3401
Lys Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu
 1               5                  10                  15      
Pro Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu
            20                  25              


<210> 3402
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3402
Lys Phe Leu Asn Glu Ser Tyr Lys His
 1               5                  


<210> 3403
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3403
Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln Thr
 1               5                  10                  15      
Gly Ser Cys Lys Phe
            20      


<210> 3404
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3404
Arg Gly Glu Gly Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp Val
 1               5                  10                  15      
Trp Ala Phe Ala Asn Asn Ser Gly Phe Val Ala Glu Leu Ala Ala Glu
            20                  25                  30          
Arg Gly
        


<210> 3405
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3405
Arg Ala Leu Ala Gly Leu Val Tyr Asn Ala Ser Gly Ser Glu His Cys
 1               5                  10                  15      
Tyr Asp Ile Tyr Arg Leu
            20          


<210> 3406
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3406
Lys Asp Tyr Gly Ser Gln Glu Asp Phe Thr Gln Val Trp Asn Thr Thr
 1               5                  10                  15      
Met Lys Gly
            


<210> 3407
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3407
Lys Cys Cys Gly Phe Thr Asn Tyr Thr Asp Phe Glu Asp Ser Pro Tyr
 1               5                  10                  15      
Phe Lys Glu
            


<210> 3408
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3408
Arg Ser Leu Thr Gln Gly Ser Leu Ile Val Gly Asp Leu Ala Pro Val
 1               5                  10                  15      
Asn Gly Thr Ser Gln Gly Lys Phe
            20                  


<210> 3409
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3409
Arg Thr Leu Ala Gly Glu Asn Gln Thr Ala Phe Glu Ile Glu Glu Leu
 1               5                  10                  15      
Asn Arg Lys
            


<210> 3410
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3410
Arg Val Pro Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu
 1               5                  10                  15      
Tyr Leu Gln His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg Gly
            20                  25                  30          


<210> 3411
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3411
Arg Asn Cys Thr Asp Ile Asp Glu Cys Arg Ile
 1               5                  10      


<210> 3412
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3412
Arg Phe Asn Gly Ser Val Ser Phe Phe Arg Gly
 1               5                  10      


<210> 3413
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3413
Lys Thr Ala Val Asn Cys Ser Ser Asp Phe Asp Ala Cys Leu Ile Thr
 1               5                  10                  15      
Lys Ala
        


<210> 3414
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3414
Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Tyr Gln Asp Ser Tyr Gly
 1               5                  10                  15      
Thr Phe Thr Ile Asn Glu Ser Thr Ile Ile Asp Ser Pro Arg Phe
            20                  25                  30      


<210> 3415
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3415
Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr Asn Trp
 1               5                  10                  15      
Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg
            20                  25                  30  


<210> 3416
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3416
Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly
 1               5                  10                  15      
Glu Gly Cys Val Ile Thr Arg Asp
            20                  


<210> 3417
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3417
Arg Asn Tyr Tyr Ala Asp Asn Gln Thr Cys Asp Gly Glu Leu Leu Phe
 1               5                  10                  15      
Asn Met Thr Lys Lys
            20      


<210> 3418
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3418
Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys Ser
 1               5                  10                  


<210> 3419
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3419
Arg Ala Gln Gln Leu Leu Ala Asn Ser Thr Ala Leu Glu Glu Ala Met
 1               5                  10                  15      
Leu Gln Glu Gln Gln Arg Leu
            20              


<210> 3420
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3420
Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe
 1               5                  10                  15  


<210> 3421
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3421
Arg Asn Leu Gln Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys
 1               5                  10                  15      
Trp
    


<210> 3422
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3422
Lys Thr Ala Asn Asp Thr Ser Thr Glu Ala Tyr Asn Leu Leu Leu Arg
 1               5                  10                  15      
Thr
    


<210> 3423
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3423
Ala Ser Asn Asn Val Thr Asp Met Phe Pro Asp Leu Pro Phe Thr Asp
 1               5                  10                  15      
Glu Leu Arg Gln
            20  


<210> 3424
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3424
Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn Ile Gln
 1               5                  10                  15      
Ser Lys Ser
            


<210> 3425
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3425
Lys Ser Gln Gly Leu Asn Leu His Thr Leu Leu Tyr Leu Gly Gly Val
 1               5                  10                  15      
Glu Pro Ser Val Pro Leu Ser Pro Ala Thr Asn Met Ser Ala His Phe
            20                  25                  30          
Arg Gly
        


<210> 3426
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3426
Arg Leu Asn Thr Thr Gly Val Ser Ala Gly Cys Thr Ala Asp Leu Leu
 1               5                  10                  15      
Val Gly Arg Ala
            20  


<210> 3427
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3427
Lys Ile Pro Ala Ile Asn Gln Thr Ile Thr Glu Ala Asn Glu Lys Thr
 1               5                  10                  15      


<210> 3428
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3428
Ile Asn Leu Thr Phe Ala Ser Asn Asn Val Thr Asp Met Phe Pro Asp
 1               5                  10                  15      
Leu Pro Phe Thr Asp Glu Leu Arg Gln
            20                  25  


<210> 3429
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3429
Arg Ile Gln Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser
 1               5                  10                  15      
Ser Gly Arg Trp
            20  


<210> 3430
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3430
Lys Ala Trp Gly Thr Pro Cys Glu Met Cys Pro Ala Val Asn Thr Ser
 1               5                  10                  15      
Glu Tyr Lys Ile
            20  


<210> 3431
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3431
Arg Leu Gly Ala Leu Asn Ser Ser Leu Gln Leu Leu Glu Asp Arg Leu
 1               5                  10                  15      


<210> 3432
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3432
Arg Ile Gln Gly Glu Glu Ile Val Phe His Asp Leu Asn Leu Thr Ala
 1               5                  10                  15      
His Gly Ile Ser His Cys Pro Thr Cys Arg Asp
            20                  25          


<210> 3433
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3433
Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu Ser Gly
 1               5                  10                  15      
Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala Leu Ala
            20                  25                  30          
Arg Arg
        


<210> 3434
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3434
Lys Ile Ile Ile Ser Pro Glu Glu Asn Val Thr Leu Thr Cys Thr Ala
 1               5                  10                  15      
Glu Asn Gln Leu Glu Arg Thr
            20              


<210> 3435
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3435
Arg Ser Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys
 1               5                  10                  15      
Tyr
    


<210> 3436
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3436
Ile Ser Ala Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn Ala Tyr
 1               5                  10                  15      
Phe Thr Arg Val
            20  


<210> 3437
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3437
Lys Leu Asp Ala Phe Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn
 1               5                  10                  15      
Ser Ser Ser Arg Ala
            20      


<210> 3438
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3438
Arg Val Pro Val Ser His Ser Phe Pro His Pro Leu Tyr Asn Met Ser
 1               5                  10                  15      
Leu Leu Lys His
            20  


<210> 3439
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3439
Lys Glu Ala Gly Asn Ile Thr Thr Asp Gly Tyr Glu Ile Leu Gly Lys
 1               5                  10                  15      
Leu
    


<210> 3440
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3440
Lys Ile Val Val Tyr Asn Gln Pro Tyr Ile Asn Tyr Ser Arg Thr
 1               5                  10                  15  


<210> 3441
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3441
Arg Leu Val Glu Ala Ala Glu Ala His Ala Gln Gln Leu Gly Gln Leu
 1               5                  10                  15      
Ala Leu Asn Leu Ser Ser Ile Ile Leu Asp Val Asn Gln Asp Arg Leu
            20                  25                  30          


<210> 3442
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3442
Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile
 1               5                  10      


<210> 3443
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3443
Lys Leu Gly Asp Cys Ile Ser Glu Asp Ser Tyr Pro Asp Gly Asn Ile
 1               5                  10                  15      
Thr Trp Tyr Arg Asn
            20      


<210> 3444
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3444
Arg Val Ala Gln Gln Asp Ser Gly Gln Tyr Ile Cys Asn Ala Thr Ser
 1               5                  10                  15      
Pro Ala Gly His Ala Glu Ala Thr Ile
            20                  25  


<210> 3445
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3445
Lys Ala Ile Asn Gln Gly Asn Tyr Gly Trp Gln Ala Gly Asn His Ser
 1               5                  10                  15      
Ala Phe Trp Gly Met Thr Leu Asp Glu Gly Ile Arg Tyr
            20                  25                  


<210> 3446
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3446
Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg Thr
 1               5                  10                  15      


<210> 3447
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3447
Lys Val Ala Ala Ala Asn Val Ser Val Thr Gln Pro Glu Ser Thr Gly
 1               5                  10                  15      
Asp Pro Asn Asn Met Thr Leu Leu Ala Glu Glu Ala Arg Lys
            20                  25                  30  


<210> 3448
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3448
Arg Ile His Gln Asn Ile Thr Tyr Gln Val Cys Arg His
 1               5                  10              


<210> 3449
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3449
Lys Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile
 1               5                  10                  15      
Ser His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu
            20                  25                  30          
Glu Ala Phe Arg Arg
        35          


<210> 3450
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3450
Arg Glu Gln Met Glu Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp
 1               5                  10                  15      
Ser Leu Thr Thr Pro Arg Leu
            20              


<210> 3451
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3451
Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val Asn Tyr Val
 1               5                  10                  15      
Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg
            20                  25                  30          
Ile
    


<210> 3452
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3452
Lys Asp Asn Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr
 1               5                  10                  15      


<210> 3453
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3453
Arg Val Asn Asn Thr Leu Ser Ser Gln Ile Ser Arg Leu
 1               5                  10              


<210> 3454
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3454
Ala Asn Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile
 1               5                  10                  15      
Lys Met
        


<210> 3455
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3455
Arg Asp Ala Cys Gly Asn Gly Thr Cys Arg Asn
 1               5                  10      


<210> 3456
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3456
Arg Thr Ala Thr Glu Ser Phe Pro His Pro Gly Phe Asn Asn Ser Leu
 1               5                  10                  15      
Pro Asn Lys Asp
            20  


<210> 3457
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3457
Lys Leu Asn Asn Leu Thr Phe Leu Tyr Leu Asp His Asn Ala Leu Glu
 1               5                  10                  15      
Ser Val Pro Leu Asn Leu Pro Glu Ser Leu Arg Val
            20                  25              


<210> 3458
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3458
Asn Ala Pro Leu Val Asn Val Thr Leu Tyr Tyr Glu Ala Leu Cys Gly
 1               5                  10                  15      
Gly Cys Arg Ala
            20  


<210> 3459
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3459
Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln Ile
 1               5                  10                  15      
Arg Gln
        


<210> 3460
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3460
Arg Asp Asn Ala Thr Leu Gln Ala Thr Leu His Ala Ala Arg Asp
 1               5                  10                  15  


<210> 3461
<211> 38
<212> PRT
<213> Homo sapiens

<400> 3461
Lys Gly Val Asn Val Thr Met Pro Ala Gln Pro Gly Thr Pro Pro Leu
 1               5                  10                  15      
Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser Leu His Glu Phe Gln Leu
            20                  25                  30          
Val Asp Leu Ser Arg Arg
        35              


<210> 3462
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3462
Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys
 1               5                  10                  15      
Val
    


<210> 3463
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3463
Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr Glu Val Thr
 1               5                  10                  15      
Gly His Arg Trp
            20  


<210> 3464
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3464
Lys Leu Asp Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val
 1               5                  10                  15      
Lys Glu
        


<210> 3465
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3465
Lys Glu Asn Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly
 1               5                  10                  15      
Gly Phe Leu Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys
            20                  25                  


<210> 3466
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3466
Arg Phe Val Asn Val Thr Val Thr Pro Glu Asp Gln Cys Arg Pro Asn
 1               5                  10                  15      
Asn Val Cys Thr Gly Val Leu Thr Arg Arg
            20                  25      


<210> 3467
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3467
Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr
 1               5                  10                  15      
Tyr Thr Ala
            


<210> 3468
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3468
Thr Leu Tyr Leu Asn Val Thr Asp Leu Lys Thr
 1               5                  10      


<210> 3469
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3469
Arg Asn His Thr Cys Asn Leu Gln Gln Thr Cys Tyr Asn Leu Gln Gly
 1               5                  10                  15      
Gly Phe Lys Cys
            20  


<210> 3470
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3470
Lys Leu Asn Tyr Thr Leu Ser Gln Gly His Arg Val
 1               5                  10          


<210> 3471
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3471
Arg Thr Leu Ser Glu Leu Met Ser Gln Thr Gly His Leu Gly Leu Ala
 1               5                  10                  15      
Asn Ala Ser Ala Pro Ser Gly Glu Gln Leu Leu Arg Thr
            20                  25                  


<210> 3472
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3472
Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser Asn
 1               5                  10                  15      
Ser Thr Trp Asp Pro Pro Val Pro Lys Cys
            20                  25      


<210> 3473
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3473
Arg Leu Asn Ala Ser Ile Ala Asp Leu Gln Ser Gln Leu Arg Ser
 1               5                  10                  15  


<210> 3474
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3474
Arg Ser Gly Gly Asn Cys Thr Asp Val Asn Glu Cys Leu Asp Pro Thr
 1               5                  10                  15      
Thr
    


<210> 3475
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3475
Lys Gln Ala Asp Glu Asp Ile Gln Gly Thr Gln Asn Leu Leu Thr Ser
 1               5                  10                  15      
Ile Glu Ser Glu Thr Ala Ala Ser Glu Glu Thr Leu Phe Asn Ala Ser
            20                  25                  30          
Gln Arg Ile
        35  


<210> 3476
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3476
Arg Ile Ile Val His Pro Gln Phe Tyr Ile Ile Gln Thr Gly Ala Asp
 1               5                  10                  15      
Ile Ala Leu Leu Glu Leu Glu Glu Pro Val Asn Ile Ser Ser Arg Val
            20                  25                  30          


<210> 3477
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3477
Arg Asn Glu Thr Gln His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys
 1               5                  10                  15      
Ser Pro Ser Cys Pro Leu Glu Arg Phe
            20                  25  


<210> 3478
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3478
Arg Thr Val Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn
 1               5                  10                  15  


<210> 3479
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3479
Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala Phe
 1               5                  10                  15      
Arg Lys
        


<210> 3480
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3480
Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly Ile
 1               5                  10                  15      
Asn Phe Asn Glu Lys Ala
            20          


<210> 3481
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3481
Gln Gln Ile Gly Tyr Leu Pro Leu Asn Gly Thr Arg Leu
 1               5                  10              


<210> 3482
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3482
Lys Thr Gly Glu Ala Asn Leu Thr Gln Ile Tyr Leu Gln Glu Ala Leu
 1               5                  10                  15      
Asp Phe Ile Lys Arg
            20      


<210> 3483
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3483
Lys Leu Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala
 1               5                  10                  15      
Ile Asp His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg
            20                  25                  30          
Lys
    


<210> 3484
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3484
Val Ala Asn Phe Ser Gln Ile Glu Thr Leu Thr Ser Val Phe Gln Lys
 1               5                  10                  15      
Lys
    


<210> 3485
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3485
Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His
 1               5                  10      


<210> 3486
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3486
Arg Asn Pro Cys Thr Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr
 1               5                  10                  15      
Lys Asn
        


<210> 3487
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3487
Lys Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met
 1               5                  10          


<210> 3488
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3488
Val Leu Gln Ile Phe Asn Ala Thr Arg Glu
 1               5                  10  


<210> 3489
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3489
Lys Gln Val Leu Ser Tyr Gly Gln Asn Leu Ser Phe Ser Phe Arg Val
 1               5                  10                  15      


<210> 3490
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3490
Arg Arg Pro Tyr Val Ser Tyr Val Asn Asn Ser Ile Ala Arg Asn
 1               5                  10                  15  


<210> 3491
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3491
Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly
 1               5                  10                  15      
Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser
            20                  25      


<210> 3492
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3492
Arg Thr Pro Ala Asp Asn Gly Leu Ile Leu Leu Met Val Asn Gly Ser
 1               5                  10                  15      
Met Phe Phe Arg Leu
            20      


<210> 3493
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3493
Arg Val Thr Asn Asp Thr Glu Ser Asp Ile Asn Tyr Leu Leu Lys Met
 1               5                  10                  15      


<210> 3494
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3494
Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile
 1               5                  10                  


<210> 3495
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3495
Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr Val Gln
 1               5                  10                  15      
Ile Ile Ala Tyr Asn Lys Asp Lys Glu
            20                  25  


<210> 3496
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3496
Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val Glu
 1               5                  10                  15      
Ala Val Ala
            


<210> 3497
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3497
Arg Ala Leu Ala Tyr Gly Glu Lys Asn Leu Thr Phe Glu Gly Pro Leu
 1               5                  10                  15      
Pro Glu Lys Ile
            20  


<210> 3498
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3498
Arg Cys Asp Gln Cys Glu Glu Asn Tyr Phe Tyr Asn Arg Ser
 1               5                  10                  


<210> 3499
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3499
Lys Met Ser Ile Gln Gly Cys Val Ala Gln Pro Ser Ser Phe Leu Leu
 1               5                  10                  15      
Asn His Thr Arg Gln
            20      


<210> 3500
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3500
Arg Ser Asp Leu Asn Pro Ala Asn Gly Ser Tyr Pro Phe Lys Ala Leu
 1               5                  10                  15      
Arg Gln
        


<210> 3501
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3501
Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr
 1               5                  10          


<210> 3502
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3502
Lys Asp Thr Gly Glu Leu Asn Val Thr Ser Ile Leu Asp Arg Glu
 1               5                  10                  15  


<210> 3503
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3503
Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser
 1               5                  10                  15      
Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Ala
            20                  25                  30          


<210> 3504
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3504
Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys Glu Pro Gly
 1               5                  10                  15      
Trp Lys Gly
            


<210> 3505
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3505
Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile Gln
 1               5                  10                  15      
Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu Glu
            20                  25                  30          
Asn Gly Lys Leu
        35      


<210> 3506
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3506
Arg Leu Asn Tyr Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu
 1               5                  10                  15      
Pro Arg Asn
            


<210> 3507
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3507
Arg Ile Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro
 1               5                  10                  15      
Ser Leu Thr Glu Leu His Leu Asp Gly Asn Lys Ile
            20                  25              


<210> 3508
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3508
Lys Thr Asn Ile Gln Gly Gln Val Pro Tyr Val Pro Ala Asn Phe Thr
 1               5                  10                  15      
Ala His Ile Ser Pro Tyr Lys Glu
            20                  


<210> 3509
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3509
Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly Asn
 1               5                  10                  15      
Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly
            20                  25                  


<210> 3510
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3510
Val Ser Leu Val Asn Gly Arg Pro Gly Ala Met Asn Phe Ser Tyr Ser
 1               5                  10                  15      
Pro Leu Leu Arg Glu
            20      


<210> 3511
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3511
Arg Ile Ala Ser Ala Val Gln Lys Asn Ala Thr Ser Thr Lys Ala Glu
 1               5                  10                  15      
Ala Glu Arg Thr
            20  


<210> 3512
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3512
Lys Val Asn Gly Thr Trp Leu Gln Ala Gly Val Val Ser Trp Gly Glu
 1               5                  10                  15      
Gly Cys Ala Gln Pro Asn Arg Pro Gly Ile Tyr Thr Arg Val
            20                  25                  30  


<210> 3513
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3513
Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val Ser Pro Thr Phe
 1               5                  10                  15      
Gln Asp Leu Leu Asn Arg Thr
            20              


<210> 3514
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3514
Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro Ala
 1               5                  10                  15      
Glu Gly Ser Lys Asp
            20      


<210> 3515
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3515
Lys Asn Gln Thr Asn Leu Glu Arg Lys
 1               5                  


<210> 3516
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3516
Arg His Glu Asn Thr Ser Ser Ser Pro Ile Gln Tyr Glu Phe Ser Leu
 1               5                  10                  15      
Thr Arg Glu
            


<210> 3517
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3517
Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala Ala Ser Thr Tyr Leu
 1               5                  10                  15      
Asn Asn Pro Tyr Val Arg Lys
            20              


<210> 3518
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3518
Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu
 1               5                  10                  15      
Thr Arg Thr
            


<210> 3519
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3519
Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp
 1               5                  10                  15      
Val Leu Gly Arg Asn
            20      


<210> 3520
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3520
Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn
 1               5                  10                  15      


<210> 3521
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3521
Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu
 1               5                  10                  15  


<210> 3522
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3522
Lys Leu Gly Ile Tyr Ala Asp Met Gly Asn Phe Thr Cys Met Gly Tyr
 1               5                  10                  15      
Pro Gly Thr Thr Leu Asp Lys Val
            20                  


<210> 3523
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3523
Lys Met Ala Ala Ala Leu Asn Ala Thr Gly Arg Pro Ile Ala
 1               5                  10                  


<210> 3524
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3524
Arg Asp Leu Gln Gly Asn Pro Ile Ala Asn Ala Thr Ile Ser Val Glu
 1               5                  10                  15      
Gly Ile Asp His Asp Val Thr Ser Ala Lys Asp
            20                  25          


<210> 3525
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3525
Lys Met Glu Met Pro Ser Thr Pro Gln Gln Leu Gln Asn Leu Thr Glu
 1               5                  10                  15      
Asp Ile Arg Glu
            20  


<210> 3526
<211> 39
<212> PRT
<213> Homo sapiens

<400> 3526
Arg Val Thr Asp Glu Ala Gly His Pro Val Pro Ser Gln Ile Gln Asn
 1               5                  10                  15      
Ser Thr Glu Thr Pro Ser Ala Tyr Asp Leu Leu Ile Leu Thr Thr Ile
            20                  25                  30          
Pro Gly Leu Ser Tyr Arg His
        35                  


<210> 3527
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3527
Lys Thr Pro Leu Val Gln Glu Val His Gln Asn Phe Ser Ala Trp Cys
 1               5                  10                  15      
Ser Gln Val Val Arg Leu
            20          


<210> 3528
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3528
Arg Val Asn Tyr Ser Leu Leu Ala Asp Ile Cys Asn Leu Trp Arg Asn
 1               5                  10                  15      


<210> 3529
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3529
Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg
 1               5                  10                  15  


<210> 3530
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3530
Ile Ser Leu Asp Asn Gly Thr Val Ile Met Asp Val Lys Gly
 1               5                  10                  


<210> 3531
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3531
Arg Asn Ser Thr Val Glu Tyr Thr Leu Asn Lys Leu
 1               5                  10          


<210> 3532
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3532
Arg Ile Ile Val His Pro Gln Phe Tyr Thr Ala Gln Ile Gly Ala Asp
 1               5                  10                  15      
Ile Ala Leu Leu Glu Leu Glu Glu Pro Val Asn Val Ser Ser His Val
            20                  25                  30          
His Thr Val Thr
        35      


<210> 3533
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3533
Arg Gly Tyr Ser Gly Val Phe Pro Asp Cys Thr Pro Cys His Gln Cys
 1               5                  10                  15      
Phe Ala Leu Trp Asp Val Ile Ile Ala Glu Leu Thr Asn Arg Thr
            20                  25                  30      


<210> 3534
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3534
Lys Val Asn Gly Thr Trp Leu Gln Ala Gly Val Val Ser Trp Asp Glu
 1               5                  10                  15      
Gly Cys Ala Gln Pro Asn Arg Pro Gly Ile Tyr Thr Arg Val
            20                  25                  30  


<210> 3535
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3535
Arg Ser Cys Ile Asn Glu Ser Ala Ile Asp Ser Arg Gly
 1               5                  10              


<210> 3536
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3536
Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro Glu Leu Lys
 1               5                  10                  15      
Thr
    


<210> 3537
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3537
Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser
 1               5                  10                  15  


<210> 3538
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3538
Arg Leu Tyr Leu Asp His Asn Asn Leu Thr Arg Met
 1               5                  10          


<210> 3539
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3539
Lys Leu Thr Ser Cys Ala Thr Asn Ala Ser Ile Cys Gly Asp Glu Ala
 1               5                  10                  15      
Arg Cys
        


<210> 3540
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3540
Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile
 1               5                  10              


<210> 3541
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3541
Lys Asn Leu Thr Val Cys Pro Asp Gly Ala Leu Phe Glu Gln Lys Gly
 1               5                  10                  15      


<210> 3542
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3542
Lys Ile Glu Ser Ile Asn Gln Gln Leu Leu Pro Leu Gly Asn Ile Ser
 1               5                  10                  15      
Asp Asn Met Asp Arg Ile
            20          


<210> 3543
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3543
Lys Thr Val Gly Ile Leu Pro Ser Asn Cys Ser Asp Ile Trp Gln Val
 1               5                  10                  15      


<210> 3544
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3544
Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe
 1               5                  10          


<210> 3545
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3545
Arg Glu Leu Phe Pro Thr Trp Leu Leu Val Met Glu Ile Leu Asn Val
 1               5                  10                  15      
Thr Leu Val Pro Tyr Gly Asn Ala Gln Glu Gln Asn Val Ser Gly Arg
            20                  25                  30          
Trp
    


<210> 3546
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3546
Lys Asn Lys Asp Tyr Tyr Ile Ile Ser Thr Ser Asn Gly Ser Leu Glu
 1               5                  10                  15      
Gly Leu Asp Asn Gln Glu Gly Gly Val Cys Gln Thr Arg Ala
            20                  25                  30  


<210> 3547
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3547
Arg Asp Ala Gly Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser
 1               5                  10                  15      
Thr Tyr Asn Phe Arg Trp
            20          


<210> 3548
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3548
Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile
 1               5                  10                  15      
Thr Pro Arg Met
            20  


<210> 3549
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3549
Leu Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys Gln His
 1               5                  10                  15      
Asn Thr Met Gly Arg Asn
            20          


<210> 3550
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3550
Arg Asp Ala Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp
 1               5                  10                  15      
Asn Gly Ile Pro Phe Pro Ser Gly Arg Thr
            20                  25      


<210> 3551
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3551
Leu Asn Leu Asn Val Thr Gly Tyr Tyr Arg Val
 1               5                  10      


<210> 3552
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3552
Arg Asp Gly Tyr Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr
 1               5                  10                  15      
His Asn Gly Thr Gly Tyr Cys Lys Cys
            20                  25  


<210> 3553
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3553
Arg Leu Asn Leu Thr Ser Pro Asp Leu Phe Trp Leu Val Phe Arg Tyr
 1               5                  10                  15      


<210> 3554
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3554
Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro Glu Asn Gly Pro Val
 1               5                  10                  15      
Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu Tyr Ile Pro Phe Ala
            20                  25                  30          
Lys Asp
        


<210> 3555
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3555
His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro
 1               5                  10                  15      
Gly His Asn Thr Lys Lys
            20          


<210> 3556
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3556
Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn
 1               5                  10                  


<210> 3557
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3557
Arg Val Tyr Ser Leu Pro Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala
 1               5                  10                  15      
Asn Gly Ile Gln Ser Gln Met Leu Ser Arg Trp
            20                  25          


<210> 3558
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3558
Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile
 1               5                  10                  15  


<210> 3559
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3559
Lys Lys Ala Asp Ile Leu Asp Val Val Gly Met Leu Tyr Val Gly Gly
 1               5                  10                  15      
Leu Pro Ile Asn Tyr Thr Thr Arg Arg
            20                  25  


<210> 3560
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3560
Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr Leu Asp Gly Phe
 1               5                  10                  15      
Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser
            20                  25              


<210> 3561
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3561
Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys Ser Asp His
 1               5                  10                  15      
Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln Ser Lys
            20                  25                  30          
Cys
    


<210> 3562
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3562
Arg Glu Thr Asn Thr Thr Ser Gln Met Gln Ala Ala Leu Leu Glu Lys
 1               5                  10                  15      
Leu
    


<210> 3563
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3563
Val Gly Tyr Leu Pro Ser Ser Gln Asn Ile Thr Ala Met Arg Glu
 1               5                  10                  15  


<210> 3564
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3564
Arg Phe Gly Asn Lys Thr Phe Pro Gln Arg Phe
 1               5                  10      


<210> 3565
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3565
Arg Leu His Asn Lys Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn
 1               5                  10                  15      


<210> 3566
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3566
Lys Met Leu Glu Ala Tyr Asn Leu Thr Glu Lys Asn
 1               5                  10          


<210> 3567
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3567
Arg Ala Ser Glu Asp Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala
 1               5                  10                  15      
Ala Ala Phe Ile Thr Asn Phe Thr Met Leu Ile Gly Asp Lys Val
            20                  25                  30      


<210> 3568
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3568
Ile Asn Tyr Asn Thr Asp Leu Tyr Asn Cys Thr Phe Pro Ala Leu Ile
 1               5                  10                  15      
Glu Asp Trp Arg Glu
            20      


<210> 3569
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3569
Arg Leu Leu Leu Gly Gly Leu Pro Glu Ser Gly Thr Ile Tyr Asn Phe
 1               5                  10                  15      
Ser Gly Cys Ile Ser Asn Val Phe Val Gln Arg Leu
            20                  25              


<210> 3570
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3570
Arg Ala Asp Asp Cys Ala Leu Pro Tyr Leu Gly Ala Ile Cys Tyr Cys
 1               5                  10                  15      
Asp Leu Phe Cys Asn Arg Thr
            20              


<210> 3571
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3571
Arg Phe Gly Tyr Gln Met Asp Glu Ser Asn Gln Cys Val Asp Val Asp
 1               5                  10                  15      
Glu Cys Ala Thr Asp Ser His Gln Cys Asn Pro Thr Gln Ile Cys
            20                  25                  30      


<210> 3572
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3572
Arg Cys Ser Gly Asp Gly Leu Asp Ser Asp Gly Asn Gln Thr Leu His
 1               5                  10                  15      
Trp Gln Ala Ile Gly Asn Pro Arg Cys
            20                  25  


<210> 3573
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3573
Arg Cys Ala Pro Asn Phe Trp Asn Leu Thr Ser Gly His Gly Cys Gln
 1               5                  10                  15      
Pro Cys Ala Cys His Pro Ser Arg Ala
            20                  25  


<210> 3574
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3574
Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu Gly Cys
 1               5                  10                  15      
Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg
            20                  25          


<210> 3575
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3575
Arg Leu Glu Gln Met Val Met Ser Ile Asn Leu Thr Gly Pro Leu Pro
 1               5                  10                  15      
Ala Pro Tyr Lys Met
            20      


<210> 3576
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3576
Arg Gly Leu Glu Tyr Asn Glu Val Asn Val Thr Leu Asp Leu Gly Gln
 1               5                  10                  15      
Val Phe His Val Ala
            20      


<210> 3577
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3577
Leu Leu Thr Val Asn Ala Thr Asp Pro Asp Ser Leu Gln His Gln Thr
 1               5                  10                  15      
Ile Arg Tyr
            


<210> 3578
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3578
Lys Val Ile Ser Leu Leu Pro Lys Glu Asn Lys Thr Arg Gly
 1               5                  10                  


<210> 3579
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3579
Lys Gly Asn Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp
 1               5                  10                  15      
Ile Pro Asp Val Gly Ser Thr Trp Trp Pro Pro Lys Thr
            20                  25                  


<210> 3580
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3580
Lys Phe Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe
 1               5                  10                  15      
Gln Ser Glu Thr Lys Asn
            20          


<210> 3581
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3581
Lys Asp Ile Thr Ala Gln Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp
 1               5                  10                  15      
Gly Ser Asn Asn Thr Gly Ser Val Asn Phe Ala Val Ile
            20                  25                  


<210> 3582
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3582
Lys Cys Glu Asn Ala Tyr Pro Gly Asn Ile Thr Asp Thr Met Val Cys
 1               5                  10                  15      
Ala Ser Val Gln Glu Gly Gly Lys Asp
            20                  25  


<210> 3583
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3583
Arg Leu Pro Phe Gln Cys Ser Ala Ser Tyr Leu Gly Asn Asp Thr Arg
 1               5                  10                  15      
Ile
    


<210> 3584
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3584
Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser Gln Ile
 1               5                  10                  15      
Arg Glu
        


<210> 3585
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3585
Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala
 1               5                  10              


<210> 3586
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3586
Arg Met His Ile Phe Gln Asn Gly Ser Leu Val Ile His Asp Val Ala
 1               5                  10                  15      
Pro Glu Asp Ser Gly Arg Tyr
            20              


<210> 3587
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3587
Lys Ser Cys Val Ala Val Thr Ser Ala Gln Pro Gln Asn Met Ser Arg
 1               5                  10                  15      
Arg
    


<210> 3588
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3588
Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly Glu Arg Leu
 1               5                  10                  


<210> 3589
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3589
Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu Ala Arg Asp
 1               5                  10                  15      


<210> 3590
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3590
Lys Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile
 1               5                  10                  


<210> 3591
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3591
Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn Val
 1               5                  10                  15      
Thr Ser Leu Arg Gly
            20      


<210> 3592
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3592
Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His Arg Gln
 1               5                  10              


<210> 3593
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3593
Arg Ser Cys Pro Ala Cys Pro Gly Ser Asn Ile Thr Ile Arg Asn
 1               5                  10                  15  


<210> 3594
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3594
Lys Leu Glu Trp Leu Gly Asn Cys Ser Gly Leu Asn Asp Glu Thr Tyr
 1               5                  10                  15      
Gly Tyr Lys Glu
            20  


<210> 3595
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3595
Lys Gly Leu Leu Asn Leu Thr Tyr Tyr Gln Gln Ile Gln Val Gln Lys
 1               5                  10                  15      
Lys
    


<210> 3596
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3596
Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe
 1               5                  10  


<210> 3597
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3597
Lys Glu Val Ile Asp Thr Asn Leu Thr Thr Leu Arg Asp
 1               5                  10              


<210> 3598
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3598
Val Asp Val Ala Met Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser
 1               5                  10                  15      
Arg Met
        


<210> 3599
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3599
Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys Tyr Leu
 1               5                  10                  15      
Ser Thr Asp Asn Phe Thr Arg Ile
            20                  


<210> 3600
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3600
Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser
 1               5                  10  


<210> 3601
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3601
Arg Ser Ser Cys Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile
 1               5                  10                  15      
Ala Phe Gly Arg Gly
            20      


<210> 3602
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3602
Arg Tyr Phe Gln Asn Tyr Ser Tyr Gly Gly Val Ile Gln Asp Asp His
 1               5                  10                  15      
Ile Pro Phe Leu Arg Arg
            20          


<210> 3603
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3603
Arg Gly Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys
 1               5                  10                  15      
Ala Gln Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg
            20                  25                  30          
Gly
    


<210> 3604
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3604
Arg Asp Tyr Ser Leu Thr Phe Gly Ala Ile Asn Gln Thr Trp Ser Tyr
 1               5                  10                  15      
Arg Ile
        


<210> 3605
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3605
Lys Val Gly Asn Asn Thr Ile His Val His Arg Glu
 1               5                  10          


<210> 3606
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3606
Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp Ala Ser Leu Cys Asp Asn
 1               5                  10                  15      
Val Leu Ala Pro Asn Val Thr Lys Gln
            20                  25  


<210> 3607
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3607
Lys Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His
 1               5                  10                  15      
Asn Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val
            20                  25                  30          
His Arg Glu
        35  


<210> 3608
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3608
Lys Asn Gly Ile Tyr Asn Ile Thr Val Leu Ala Ser Asp Gln Gly Gly
 1               5                  10                  15      
Arg Thr
        


<210> 3609
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3609
Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly Ser Thr Cys Ala
 1               5                  10                  15      
Arg Ser
        


<210> 3610
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3610
Thr Asn Asn Cys Tyr Ser Asn Glu Thr Val Ile Leu Thr Pro Thr Met
 1               5                  10                  15      
Asp Ser Arg Leu
            20  


<210> 3611
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3611
Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr Ile
 1               5                  10                  15      
Asn Gly Arg Tyr
            20  


<210> 3612
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3612
Arg His Pro Asp Ala Val Ala Trp Ala Asn Leu Thr Asn Ala Ile Arg
 1               5                  10                  15      
Glu
    


<210> 3613
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3613
Lys Gln Tyr Asn Ser Thr Gly Asp Tyr Arg Ser
 1               5                  10      


<210> 3614
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3614
Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp Asn Trp Leu Ala Asn
 1               5                  10                  15      
Phe Thr Phe
            


<210> 3615
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3615
Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser Leu Leu Leu Glu Tyr
 1               5                  10                  15      
Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly Arg Gln
            20                  25                  


<210> 3616
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3616
Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala
 1               5                  10                  


<210> 3617
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3617
Lys Gly Thr Ser Pro Phe Met Asp Ala Leu Thr Ala Asn Gly Thr Thr
 1               5                  10                  15      
Asn Ile Gln Thr Ser Val Thr Gly Val Thr Ala Ser Lys Arg
            20                  25                  30  


<210> 3618
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3618
Met Asp Lys Gln Asn Ser Gln Met Asn Ala Ser His
 1               5                  10          


<210> 3619
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3619
Met Asp Ala Leu Thr Ala Asn Gly Thr Thr Asn
 1               5                  10      


<210> 3620
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3620
Tyr Phe Met Asn Tyr Asn Ser Ser Val Ser Phe Glu Glu Arg Leu
 1               5                  10                  15  


<210> 3621
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3621
Arg Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys Asp
 1               5                  10                  15      
Ser His Gly
            


<210> 3622
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3622
Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro Ser
 1               5                  10                  15      
Pro Lys Ile
            


<210> 3623
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3623
Val Asn Asn Ser Leu Ser Phe Phe Asp Leu Ser Glu Leu Gly Met Gly
 1               5                  10                  15      
Lys Ser
        


<210> 3624
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3624
Arg Asp Pro Leu Asn Gly Gln Ala Val Pro Ala Asn Gly Thr Tyr Glu
 1               5                  10                  15      
Phe Gly Tyr Gln Met His Phe
            20              


<210> 3625
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3625
Arg Val Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys
 1               5                  10                  15      
Gly
    


<210> 3626
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3626
Lys Val Tyr Val Tyr Ala Leu Asn Gln Thr Arg Phe
 1               5                  10          


<210> 3627
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3627
Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp Asp Pro Cys Leu Leu
 1               5                  10                  15      
Thr Asn Arg Ser
            20  


<210> 3628
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3628
Arg Cys Glu Cys Pro Phe Gly Tyr Thr Leu Ala Gly Asn Glu Cys Val
 1               5                  10                  15      
Asp Thr Asp Glu Cys Ser Val Gly Asn Pro Cys Gly Asn Gly Thr Cys
            20                  25                  30          
Lys Asn
        


<210> 3629
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3629
Arg Leu Leu Gly Thr Lys Asn Ala Ser Cys Leu Val Leu Ala Ala Gln
 1               5                  10                  15      
His Ala Ser Ala
            20  


<210> 3630
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3630
Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val Val Thr
 1               5                  10                  15      


<210> 3631
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3631
Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr Phe Tyr Glu Val
 1               5                  10                  15      
Glu Ser Ile Leu Lys Asn
            20          


<210> 3632
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3632
Lys Ser Thr Glu Gly Gln Ser Ser Leu Thr Val Thr Asn Val Thr Glu
 1               5                  10                  15      
Glu His Tyr Gly Asn Tyr Thr Cys Val Ala Ala Asn Lys Leu
            20                  25                  30  


<210> 3633
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3633
Lys Ala Cys Asn Cys Ser Thr Val Gly Ser Leu Asp Phe Gln Cys Asn
 1               5                  10                  15      
Val Asn Thr Gly Gln Cys Asn Cys His Pro Lys Phe
            20                  25              


<210> 3634
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3634
Arg Tyr Leu Tyr Leu Ala Ser Asn His Ser Asn Lys Trp
 1               5                  10              


<210> 3635
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3635
Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala Val Asp Asn Gly Ser
 1               5                  10                  15      
Leu Ala Asn Thr Pro His Leu Arg Glu
            20                  25  


<210> 3636
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3636
Lys Asp Val Asp Glu Cys Ala Leu Gly Thr His Asn Cys Ser Glu Ala
 1               5                  10                  15      
Glu Thr Cys His Asn Ile Gln Gly Ser Phe Arg Cys
            20                  25              


<210> 3637
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3637
Lys Met Tyr Asn His Ser Trp Pro Glu Ser Leu Ala Cys Asp Glu Leu
 1               5                  10                  15      
Pro Val Tyr Asp Arg Gly
            20          


<210> 3638
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3638
Arg Glu Ala Cys Gln Gly Thr Ser Pro Pro Val Val Ser Cys Tyr Asn
 1               5                  10                  15      
Ala Ser Asp His Val Tyr Lys Gly
            20                  


<210> 3639
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3639
Arg Leu Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile
 1               5                  10                  15      
Glu Gly Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val
            20                  25                  30          
Lys Asp
        


<210> 3640
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3640
Lys Gly Ala Asn Ala Ser Asn Pro Gly Pro Phe Gly Asp Val Leu Cys
 1               5                  10                  15      
Asp Ser Pro Tyr Gln Leu Ile Leu Ser Ala Phe Asp Phe Ile Lys Asn
            20                  25                  30          


<210> 3641
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3641
Arg Leu His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn
 1               5                  10                  15      


<210> 3642
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3642
Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu Tyr Pro Ile
 1               5                  10                  15      
Lys Asn
        


<210> 3643
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3643
Ser Ala Leu Asn Leu Pro Tyr His Met Pro Glu Asn Lys Thr Ile His
 1               5                  10                  15      
Asp Phe Phe Lys Arg Lys
            20          


<210> 3644
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3644
Arg Ser Pro Tyr Ala Ser Thr His Val Asn Val Ser Trp Glu Ser Ala
 1               5                  10                  15      
Ser Gly Ile Ala Thr Leu Trp Ala Asn Gly Lys Leu
            20                  25              


<210> 3645
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3645
Arg Ser Met Val Tyr Leu Thr Ile Lys Pro Leu Asn Leu Ser Gln Val
 1               5                  10                  15      
Glu Gly Lys Pro Ser Pro Trp Leu Ser Val Asp Thr
            20                  25              


<210> 3646
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3646
Arg Arg Asp Asn Ala Ser Gly Asp Ala Ala Lys Gly Lys Val Lys Ala
 1               5                  10                  15      


<210> 3647
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3647
Arg Pro Phe Pro Gly Asn Met Ser Ser Met Pro Pro Ser Ser Pro Gly
 1               5                  10                  15      
Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val
            20                  25                  30          
Asn Arg Lys
        35  


<210> 3648
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3648
Arg Asn Ser Glu Leu Ile Ala Asn Gly Ser Ser His Arg Ile
 1               5                  10                  


<210> 3649
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3649
Arg Asn Met Met Asn His Ser Gln Val Gly Gln Gly Ile Gly Ile Pro
 1               5                  10                  15      
Ser Arg Thr
            


<210> 3650
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3650
Arg Asn Leu Asn His Ser Leu Pro Ser Asp Phe Thr Phe Gln Asn Met
 1               5                  10                  15      
Asn Ser Lys Arg Lys Ala
            20          


<210> 3651
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3651
Arg Asn Cys Glu Asp Trp Gly Ala Gly Asn Ser Thr Leu Ala Ser Leu
 1               5                  10                  15      
Gln Pro Val Leu Gln Val Arg Ala
            20                  


<210> 3652
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3652
Arg Asn Ser Ser Val Ala Ser Asp Leu His Gly Glu Asp Met Ile Val
 1               5                  10                  15      
Thr Pro Phe Ala Gln Val Leu
            20              


<210> 3653
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3653
Arg Asn Asn Ser Pro Asp Gly Asn Thr Asp Ser Ser Ala Leu Asp Cys
 1               5                  10                  15      
Tyr Asn Pro Met Thr Asn Gln Trp Ser Pro Cys Ala Pro Met Ser Val
            20                  25                  30          
Pro Arg Asn
        35  


<210> 3654
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3654
Arg Met Lys Tyr Tyr Glu Leu Ile Val Asn Gly Ser Tyr Thr Pro
 1               5                  10                  15  


<210> 3655
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3655
Arg Ile Asn Asp Ser Gln Glu Gly Gly Cys Asn Ser Arg Gln
 1               5                  10                  


<210> 3656
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3656
Arg Gly Ser Cys Gln Arg Ser Gly Pro Leu Gly Asp Gln Pro Phe Ala
 1               5                  10                  15      
Gly Leu Leu Pro Lys Asn Leu Ser Arg Glu
            20                  25      


<210> 3657
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3657
Arg Gly His Asn Ser Ser Asn Ser Pro Ser Leu Gln Ala Gly Gly Ala
 1               5                  10                  15      
Glu Gly Ala Gly Asp Arg Gly Arg Asp
            20                  25  


<210> 3658
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3658
Arg Ala Leu Cys Thr Pro Gly Tyr Asn Ala Arg Ala Pro Leu His Tyr
 1               5                  10                  15      
Leu Ala Pro Leu Leu Ser Asn Leu Ser Gln Arg Pro Ala Ala Arg Ala
            20                  25                  30          
Phe
    


<210> 3659
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3659
Pro Gly Pro Asp Pro Ser Leu Asp Arg Met Leu Ser Ser Ser Ser Ser
 1               5                  10                  15      
Val Ser Ser Leu Asn Ser Ser Thr Val Arg Arg Glu
            20                  25              


<210> 3660
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3660
Asn His Thr Asn Met Gly Asn Leu Ala Val Leu Ser Gln Gly Asn Thr
 1               5                  10                  15      
Ser Ser Ser Arg Arg Lys Thr
            20              


<210> 3661
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3661
Met Thr Pro Asn Pro Gly Tyr Gln Pro Ser Met Asn Thr Ser Asp Met
 1               5                  10                  15      
Met Gly Arg Met Ser Tyr Glu Pro Asn Lys Asp Pro Tyr Gly Ser Met
            20                  25                  30          
Arg Lys Ala
        35  


<210> 3662
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3662
Met Met Leu Leu Gln Gln Asn Met Thr Gln Ile Gln His Asn His His
 1               5                  10                  15      
Arg Val
        


<210> 3663
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3663
Met Leu Val Ala Ala Ser Leu Ser Ile Asn Ala Thr Gly Ser Thr Met
 1               5                  10                  15      
Leu Leu Arg Glu
            20  


<210> 3664
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3664
Met Gly Gln Ile Ala Ile Val Ser Phe Gln Asn Ser Thr Pro Lys Val
 1               5                  10                  15      
Ile Glu Cys Phe Asn Val Glu Ser Arg Ile
            20                  25      


<210> 3665
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3665
Met Gly Asp Ser Asn Ile Ser Ser Pro Gly Leu Gln Pro Ser Thr Gln
 1               5                  10                  15      
Leu Ser Asn Leu Gly Ser Thr Glu Thr Leu Glu Glu Met Pro Ser Gly
            20                  25                  30          
Ser Gln Asp Lys Ser
        35          


<210> 3666
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3666
Met Phe Thr Arg Leu Ser Asn Cys Ala Asn Arg Thr Ile Leu Tyr Asp
 1               5                  10                  15      
Met Tyr Ser Tyr Val Trp Asp Ile Lys Ser Ile Met Ser Met Val Lys
            20                  25                  30          
Ser
    


<210> 3667
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3667
Met Glu Ile Phe Ser Pro Met Pro Gly Glu Ser Cys Glu Asn Ala Asn
 1               5                  10                  15      
Thr Ser Leu Gly Arg Arg Met
            20              


<210> 3668
<211> 40
<212> PRT
<213> Homo sapiens

<400> 3668
Leu Pro Leu Ala Ala Thr Gln Asp Thr Met Ser Gln Ser Gly Ala Val
 1               5                  10                  15      
Ser Cys Cys Pro Gly Ala Thr Asn Gly Ser Leu Gly Arg Ser Asp Gly
            20                  25                  30          
Val Ala Lys Met Ser Pro Lys Asp
        35                  40  


<210> 3669
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3669
Leu Cys Met Asn Glu Thr Gly Phe Val Ser Gly Leu Trp Ala Leu Asp
 1               5                  10                  15      
Leu Ser Lys Asn
            20  


<210> 3670
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3670
Lys Val Lys Ile Val Ala Cys Asp Gly Lys Asn Thr Gly Ser Asn Thr
 1               5                  10                  15      
Thr Glu
        


<210> 3671
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3671
Lys Ser Val Ser Ile Gln Asn Ile Thr Gly Val Gly Asn Asp Glu Asn
 1               5                  10                  15      
Met Ser
        


<210> 3672
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3672
Lys Ser Asn Gln Ser Tyr Pro Thr Pro Val Thr Val Glu Lys Asp Arg
 1               5                  10                  15      
Ile
    


<210> 3673
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3673
Lys Ser Phe Ser Glu Thr Ser Ser Glu Asn Asp Thr Glu Gly Val Ser
 1               5                  10                  15      
Val Ala
        


<210> 3674
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3674
Lys Ser Phe Arg Gln Asn Ser Thr Leu Ile Gln His Lys Lys
 1               5                  10                  


<210> 3675
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3675
Lys Ser Ala Leu Ala Asn Leu Ser Asp Glu Thr Glu Thr Leu Lys Asn
 1               5                  10                  15      


<210> 3676
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3676
Lys Gln Val Thr Asn Ser Ser Ser Val Asp Arg Gly Trp Val Thr His
 1               5                  10                  15      
Ser Val Cys Gly
            20  


<210> 3677
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3677
Lys Asn Leu Ala Gln Thr Tyr Leu Ala Arg Asn Met Ser Glu Arg Ser
 1               5                  10                  15      
Ala Met Ala Ala Val Leu Ala Met Arg Asp
            20                  25      


<210> 3678
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3678
Lys Met Glu Asp Leu Thr Asn Val Ser Ser Leu Leu Asn Met Glu Arg
 1               5                  10                  15      
Ala Arg Asp Lys Ala
            20      


<210> 3679
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3679
Lys Leu Val Leu Ser Leu Leu Ser Gly Leu Pro Asn Glu Val Asp Phe
 1               5                  10                  15      
Ala Ile Asn Val Cys Thr Leu Leu Ser Asn Glu Ser Lys His
            20                  25                  30  


<210> 3680
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3680
Lys Leu Thr His Leu Asn Phe Ser Ser Asn Lys Leu Gly Met Thr Val
 1               5                  10                  15      
Pro Leu Ile Leu Lys Ala Leu Arg His Ser Ala
            20                  25          


<210> 3681
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3681
Lys Leu Gln Arg Ala Gln Ala Glu Leu Glu Asn Val Ser Gly Ala Leu
 1               5                  10                  15      
Asn Glu Ala Glu
            20  


<210> 3682
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3682
Lys Leu Glu Trp Met Asn Asn Gly Tyr Ser Gly Val Gly Asn Ser Ser
 1               5                  10                  15      
Val Ser Gly His Gly Ile Leu Pro Ser Tyr Gln Glu Leu Val Glu Asp
            20                  25                  30          
Arg Phe
        


<210> 3683
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3683
Lys Lys Asn Ala Ser Ser Arg Pro Ala Ser Ala Ile Ser Gly Gln Asn
 1               5                  10                  15      
Asn Asn His Ser Gly Asn Lys
            20              


<210> 3684
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3684
Lys Lys Lys Leu Glu Arg Phe Asn Ser Thr Arg Phe Asn Leu Asp Asn
 1               5                  10                  15      
Leu Ala Asp Leu Glu Asn Leu Val Gln Arg Arg
            20                  25          


<210> 3685
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3685
Lys Lys Ile Asn Gln Thr Lys Gly Leu Val Pro Glu Cys Leu Asn Thr
 1               5                  10                  15      
Leu Cys Ser Pro Met His Ser Arg Leu
            20                  25  


<210> 3686
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3686
Lys Lys Phe Lys Asp Asp Ser Asn His Thr Ile Gly Val Glu Phe Gly
 1               5                  10                  15      
Ser Lys Ile
            


<210> 3687
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3687
Lys Lys Glu Asn Glu Thr Leu Lys Ser Asp Leu Asn Asn Leu Met Glu
 1               5                  10                  15      
Leu Leu
        


<210> 3688
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3688
Lys Ile Ser Leu Asp Asn Leu Ser Glu Asp Gly Ala Gln Leu Leu Tyr
 1               5                  10                  15      
Lys Thr
        


<210> 3689
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3689
Lys Phe Gln Asn Cys Ser Val Leu Pro Gly Gly Val Tyr Val Ser Glu
 1               5                  10                  15      
Thr Gln Asn Arg Val
            20      


<210> 3690
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3690
Lys Glu Asn Ile Gly Leu Asn Val Phe Leu Ser Asn Gln Ser Cys Phe
 1               5                  10                  15      
Pro Ala Ala Cys Glu Asn Pro Gln Arg Lys Ser
            20                  25          


<210> 3691
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3691
Lys Glu Cys Asp Glu Ala Ile Asn Asn Cys Ser His Phe Asn Ile Arg
 1               5                  10                  15      
Glu
    


<210> 3692
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3692
Lys Asp Gly Gln Ala Gln Thr Leu Gln Asn His Ser Gly Leu Ser Ala
 1               5                  10                  15      
Pro Val Pro Arg Gly
            20      


<210> 3693
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3693
Lys Cys Gly Lys Ala Phe Asn Ile Ser Ser Met Phe Thr Lys Cys Lys
 1               5                  10                  15      
Ile
    


<210> 3694
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3694
His Ser Met Asp Thr Asn Ser Ser Gly Met Ser Ser Leu Ile Asn Pro
 1               5                  10                  15      
Leu Ser Ser Pro Pro Ser Cys Asn Asn Asn Pro Lys Ile
            20                  25                  


<210> 3695
<211> 39
<212> PRT
<213> Homo sapiens

<400> 3695
Gly Thr Thr Ser Ala Tyr Pro Ser His Pro Met Pro Tyr Ser Ser Val
 1               5                  10                  15      
Leu Thr Gln Asn Ser Leu Gly Asn Asn His Ser Phe Ser Thr Ala Asn
            20                  25                  30          
Gly Leu Ser Val Asp Arg Leu
        35                  


<210> 3696
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3696
Met Pro Leu Ser Ser Pro Asn Ala Ala Ala Thr Ala Ser Asp Met Asp
 1               5                  10                  15      
Lys Asn Ser Gly Ser Asn Ser Ser Ser Ala Ser Ser Gly Ser Ser Lys
            20                  25                  30          
Gly Gln Gln Pro Pro
        35          


<210> 3697
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3697
Thr Val Phe Asn Ala Ser Gly Leu Gln Ala Leu Val Ala Gln Tyr Gly
 1               5                  10                  15      
Asp Trp Phe Ser Tyr Asp Gly Ser Pro Arg Ala
            20                  25          


<210> 3698
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3698
Ser Glu Ala Gln Gln Arg Ala Gln Ala Ala Leu Asp Lys Ala Asn Ala
 1               5                  10                  15      
Ser Arg Gly
            


<210> 3699
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3699
Arg Arg Ala Asn Thr Ser Ala Leu Ala Val Pro Ser Pro Val Ser Asn
 1               5                  10                  15      
Ser Ala Ser Ala Arg His
            20          


<210> 3700
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3700
Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu Thr Val Cys
 1               5                  10                  15      
Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu Lys Cys
            20                  25                  30      


<210> 3701
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3701
Arg Leu Glu Asp Arg Phe Asn Ser Thr Leu
 1               5                  10  


<210> 3702
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3702
Arg Gly Leu Asn Val Ser Cys Leu Ser Val Gln Gly Ser Ala Ser Ile
 1               5                  10                  15      
Val Ala Pro Leu Leu Leu Arg
            20              


<210> 3703
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3703
Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe Thr Gly Glu
 1               5                  10                  15      
Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr Gln Gly Arg
            20                  25                  30          
Cys
    


<210> 3704
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3704
Met Arg Arg Ser Glu Ser Thr Tyr Ser Val Asn Ser Thr Gly Arg Arg
 1               5                  10                  15      
Gly
    


<210> 3705
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3705
Lys Asn Ser Ser Cys Leu Pro Asn Pro Cys Val Asn Gly Gly Thr Cys
 1               5                  10                  15      
Val Gly Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg Asp
            20                  25                  


<210> 3706
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3706
Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His Asn Gly Arg
 1               5                  10                  15      
Glu Thr Ile Tyr
            20  


<210> 3707
<211> 35
<212> PRT
<213> Homo sapiens

<400> 3707
Lys Leu Val Asp Pro Gln Gly Pro Leu Lys Asp Cys Ile Phe Asp Leu
 1               5                  10                  15      
Cys Leu Gly Gly Gly Asn Leu Ser Ile Leu Cys Ser Asn Ile His Ala
            20                  25                  30          
Tyr Val Ser
        35  


<210> 3708
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3708
Lys His Ser Val Leu Trp Asn Ala Met Ile His Pro Leu Cys Asn Met
 1               5                  10                  15      
Thr Leu Lys Gly
            20  


<210> 3709
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3709
Lys Gly Ser Val Val Leu Thr Cys His Thr Asn Asn Thr Gly Thr Ser
 1               5                  10                  15      
Phe Gln Trp Ile Phe Asn Asn Gln Arg Leu
            20                  25      


<210> 3710
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3710
Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser Ser Asp
 1               5                  10                  15      
Glu Ser Tyr Thr Leu Leu Val Lys Glu
            20                  25  


<210> 3711
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3711
Ala Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn
 1               5                  10                  15      
Leu Ser Asp Cys Gly Cys Asp Lys Glu
            20                  25  


<210> 3712
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3712
Met Gly Ser Gly Trp Val Pro Trp Val Val Ala Leu Leu Val Asn Leu
 1               5                  10                  15      
Thr Arg Leu Asp Ser Ser Met Thr Gln Gly Thr Asp Ser Pro
            20                  25                  30  


<210> 3713
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3713
Lys Gly Ala Ser Leu Asp Gly Leu Pro Pro Val Ile Leu Gln Gly Pro
 1               5                  10                  15      
Ala Asn Gln Thr Leu Val Leu Gly Ser Ser
            20                  25      


<210> 3714
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3714
Thr Ile Ser Trp Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp
 1               5                  10                  15      
Pro Gln Arg Val
            20  


<210> 3715
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3715
Arg Tyr Asn Cys Thr Ala Thr Asn His Ile Gly Thr Arg Phe
 1               5                  10                  


<210> 3716
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3716
Arg Val Ser Ala Pro Asp Gly Pro Cys Pro Thr Gly Phe Glu Arg Val
 1               5                  10                  15      
Asn Gly Ser Cys Glu Asp Val Asp Glu Cys Ala Thr Gly Gly Arg Cys
            20                  25                  30          


<210> 3717
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3717
Arg Val Asn Leu Thr Thr Asn Thr Ile Ala Val Thr Gln Thr Leu Pro
 1               5                  10                  15      
Asn Ala Ala Tyr Asn Asn Arg Phe
            20                  


<210> 3718
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3718
Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala
 1               5                  10      


<210> 3719
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3719
Arg Val Phe Asp Leu Gln Gln Asn Leu Gly Ser Val Asn Val Ser Thr
 1               5                  10                  15      
Gly Cys Ala Pro Ala Leu Gln Ala Gln Thr Pro Gly Leu Gly Pro Arg
            20                  25                  30          
Gly
    


<210> 3720
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3720
Arg Ser Ile Leu Thr Val Thr Asn Val Thr Gln Glu His Phe Gly Asn
 1               5                  10                  15      
Tyr Thr Cys Val Ala Ala Asn Lys Leu
            20                  25  


<210> 3721
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3721
Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val Asn Ser Val Gly
 1               5                  10                  15      
Val Arg Arg
            


<210> 3722
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3722
Arg Asn Gln Glu Leu Glu Asp Asn Val His Ile Ser Pro Asn Gly Ser
 1               5                  10                  15      
Ile Ile Thr
            


<210> 3723
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3723
Arg Leu His Glu Ala His Ala Gln Val Gly Asn Leu Ser Gln Ala Ile
 1               5                  10                  15      
Glu Asn Val Leu Ser Val Leu Leu Phe Tyr Pro Glu Asp Glu Ala Ala
            20                  25                  30          
Lys Arg
        


<210> 3724
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3724
Arg Lys Cys Val Cys Asn Tyr Leu Gly Thr Val Gln Glu His Cys Asn
 1               5                  10                  15      
Gly Ser Asp Cys Gln Cys Asp Lys Ala
            20                  25  


<210> 3725
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3725
Arg Gly Asn Pro Pro His Ser Ala Pro Cys Val Pro Asn Gly Ser Ala
 1               5                  10                  15      
Leu Leu Leu Ser Asn Pro Ala Tyr Arg Leu
            20                  25      


<210> 3726
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3726
Arg Gly Lys Ala Asn Ser Thr Gly Thr Leu Val Ile Thr Asp Pro Thr
 1               5                  10                  15      
Arg Ile
        


<210> 3727
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3727
Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg
 1               5                  10                  15      
Pro Val
        


<210> 3728
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3728
Arg Cys Glu Ile Cys Ala Pro Gly Phe Tyr Gly Asn Ala Leu Leu Pro
 1               5                  10                  15      
Gly Asn Cys Thr Arg Cys
            20          


<210> 3729
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3729
Arg Ala Ala Ala Gln Val Leu Gly Ser Ser Gly Leu Phe Asn Asn His
 1               5                  10                  15      
Gly Leu Gln Val Gln Gln Gln Gln Gln Arg Asn Leu Ser Leu His Glu
            20                  25                  30          


<210> 3730
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3730
Met Val Gly Asn Thr Asp Ile Ser Cys Cys Tyr Asn Ser Ser Thr Gly
 1               5                  10                  15      
Ser Asp Ile His Gly Asp Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg
            20                  25                  30          
Gly
    


<210> 3731
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3731
Lys Val Asn Ile Ser Asn Tyr Ser Leu Val Met Glu Ser Asp Ala Gly
 1               5                  10                  15      
Thr Phe Leu Pro Thr Gly
            20          


<210> 3732
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3732
Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly Leu Glu Ser Leu Lys
 1               5                  10                  15      
Arg
    


<210> 3733
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3733
Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro Thr
 1               5                  10                  15      
Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro
            20                  25                  


<210> 3734
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3734
Lys Met Cys Ala Gln Gln Leu Gly Asp Asn Cys Thr Glu Ala Ala Ile
 1               5                  10                  15      
Cys Asp Pro His Arg Gly
            20          


<210> 3735
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3735
Lys Ile Trp Trp Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln
 1               5                  10                  15      


<210> 3736
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3736
Lys Ile Val Tyr Lys Pro Val Gly Ser Asn Glu Pro Met Glu Ala Phe
 1               5                  10                  15      
Val Gly Glu Met Thr Ser Tyr Thr Leu His Asn Leu Asn Pro Ser Thr
            20                  25                  30          


<210> 3737
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3737
Lys Gly Val Val Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr
 1               5                  10                  15      
Ile Ser Val Ser Gly Ile Asn His Gly Val Lys Thr
            20                  25              


<210> 3738
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3738
Lys Phe Phe Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu
 1               5                  10                  15      
Leu Val Thr Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr
            20                  25                  30      


<210> 3739
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3739
Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys Thr
 1               5                  10                  15      
Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile
            20                  25          


<210> 3740
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3740
Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr Gly Ile Asn
 1               5                  10                  15      
Cys Ser Ser Arg Cys
            20      


<210> 3741
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3741
Ala Asn Leu Ser Val Glu Ala Gln Pro Pro Trp Leu Pro Gly Leu Glu
 1               5                  10                  15      
Ala Arg Tyr
            


<210> 3742
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3742
Arg Ile Leu Gln Asn Leu Thr Thr Leu Ala Thr Asn Asn Gly Tyr Ile
 1               5                  10                  15      
Lys Phe
        


<210> 3743
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3743
Arg His Gln Asn Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe Thr
 1               5                  10                  15      
Gln Leu Ala Ser Asp Cys Ser Pro Lys Glu
            20                  25      


<210> 3744
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3744
Arg Gly Phe Val Val Leu Pro Ile Thr Glu Phe Leu Val Gly Asp Leu
 1               5                  10                  15      
Val Val Thr Gln Asn Thr Ser Leu Pro Trp Pro
            20                  25          


<210> 3745
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3745
Met Tyr Met Phe Leu Gly Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val
 1               5                  10                  15      
Ser Ser Thr Val Pro Lys Met
            20              


<210> 3746
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3746
Met Leu Met Leu Leu Leu Ala Val Pro Asn Ile Ile Leu Thr Asn Gln
 1               5                  10                  15      
Ser Val Arg Glu Val Thr Gln Ile Lys Cys
            20                  25      


<210> 3747
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3747
Met Phe Phe Ile Leu Leu Asn Met Phe Leu Ala Ile Ile Asn Asp Thr
 1               5                  10                  15      
Tyr Ser Glu Val Lys Ser Asp Leu Ala Gln Gln Lys Ala
            20                  25                  


<210> 3748
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3748
Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg Ser Lys Asp
 1               5                  10                  15      
Leu Arg His
            


<210> 3749
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3749
Leu Glu Leu Lys Asn Asn Ala Ser Lys Leu
 1               5                  10  


<210> 3750
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3750
Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr
 1               5                  10                  15      
Gln Lys Val
            


<210> 3751
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3751
Lys Ser Asn Ser Ser Phe Met Ser Arg Glu
 1               5                  10  


<210> 3752
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3752
Lys Arg Cys Asn Val Ser Asp Glu Val Gln Arg Gly Met Pro Gly Asn
 1               5                  10                  15      
Val Thr Pro Cys Thr Arg Leu
            20              


<210> 3753
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3753
Lys Gln Asn Thr Ala Val Asn Ser Ser Ser Arg Asn
 1               5                  10          


<210> 3754
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3754
Lys Asn Phe Ser Ala Ser Ser Ile Ala Lys Ile
 1               5                  10      


<210> 3755
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3755
Lys Glu Ser Asn Phe Ser Asp Val Asn Thr Asn Arg Ser Ala Phe Lys
 1               5                  10                  15      
Tyr
    


<210> 3756
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3756
Lys Glu Ala Asp Asp Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro
 1               5                  10                  15      
Pro Glu Phe Trp Asn Lys Ser
            20              


<210> 3757
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3757
Lys Ala Met Asn Gly Asn Leu Ser Asn Met Tyr Glu Val Leu Asn Asn
 1               5                  10                  15      
Asn Glu Glu Ser Leu Thr Cys Gly Ile Glu Gln His Thr Gly Glu Asn
            20                  25                  30          
Val Ser Arg Arg
        35      


<210> 3758
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3758
Glu Lys Ser Asn Glu Thr Asn Gly Tyr Leu Asp Ser Ala Gln Ala Gly
 1               5                  10                  15      
Pro Ala Ala Gly Pro Gly Ala Pro Gly Thr Ala Ala Gly Arg Ala
            20                  25                  30      


<210> 3759
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3759
Met Thr Arg Lys Arg Thr Tyr Trp Val Pro Asn Ser Ser Gly Gly Leu
 1               5                  10                  15      
Val Asn Arg Gly
            20  


<210> 3760
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3760
Met Asp Asn Ala Ser Phe Ser Glu Pro Trp Pro Ala Asn Ala Ser Gly
 1               5                  10                  15      
Pro Asp Pro
            


<210> 3761
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3761
Met Asp Leu Gly Asn Ser Gly Asn Asp Ser Val Val Thr Lys Phe
 1               5                  10                  15  


<210> 3762
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3762
Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His Ile
 1               5                  10                  15      
Asp Lys Glu
            


<210> 3763
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3763
Arg Val Phe Gly Ser Gln Asn Leu Thr Thr Val Lys Leu
 1               5                  10              


<210> 3764
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3764
Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp Thr
 1               5                  10                  15      
Ser Tyr Ser Lys Gly
            20      


<210> 3765
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3765
Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe
 1               5                  10      


<210> 3766
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3766
Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg
 1               5                  10                  15      
Leu
    


<210> 3767
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3767
Arg Thr Glu Ala Gly Ala Phe Glu Tyr Val Pro Asp Pro Thr Phe Glu
 1               5                  10                  15      
Asn Phe Thr Gly Gly Val Lys Lys
            20                  


<210> 3768
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3768
Lys His Asn Asn Asp Thr Gln His Ile Trp Glu Ser Asp Ser Asn Glu
 1               5                  10                  15      
Phe Ser Val Ile Ala Asp Pro Arg Gly
            20                  25  


<210> 3769
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3769
Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro Ile Leu Asn Gln Phe
 1               5                  10                  15      
Thr Pro Ala Asn Ile Ser Arg Gln
            20                  


<210> 3770
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3770
Arg Phe Thr Phe Thr Ser His Thr Pro Gly Glu His Gln Ile Cys Leu
 1               5                  10                  15      
His Ser Asn Ser Thr Lys Phe
            20              


<210> 3771
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3771
Arg Ile Ala Pro Ala Ser Asn Val Ser His Thr Val Val Leu Arg Pro
 1               5                  10                  15      
Leu Lys Ala
            


<210> 3772
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3772
Lys Phe Leu Ser Ser Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn
 1               5                  10                  15      
Ala Ser Gly Arg Ala
            20      


<210> 3773
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3773
Arg Thr Ser Leu Glu Leu Trp Met His Thr Asp Pro Val Ser Gln Lys
 1               5                  10                  15      
Asn Glu Ser Val Arg Asn
            20          


<210> 3774
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3774
Lys Tyr Leu Gln Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Met
 1               5                  10                  15      
Asp Thr Glu Ile Arg Ile
            20          


<210> 3775
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3775
Arg Ala Phe Ser Asn Ser Ser Tyr Val Leu Asn Pro Thr Thr Gly Glu
 1               5                  10                  15      
Leu Val Phe Asp Pro Leu Ser Ala Ser Asp Thr Gly Glu Tyr Ser Cys
            20                  25                  30          
Glu Ala Arg Asn
        35      


<210> 3776
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3776
Arg Leu Leu Asn Thr Thr Asp Val Tyr Leu Leu Pro Ser Leu Asn Pro
 1               5                  10                  15      
Asp Gly Phe Glu Arg Ala
            20          


<210> 3777
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3777
Arg Glu Ala Gly Asn His Thr Ser Gly Ala Gly Leu Val Gln Ile Asn
 1               5                  10                  15      
Lys Ser
        


<210> 3778
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3778
Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys Asn Glu Ser Leu Glu
 1               5                  10                  15      
Thr Tyr Pro Val Met Lys Tyr
            20              


<210> 3779
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3779
Arg Ala Glu Pro Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys
 1               5                  10                  15      
Val
    


<210> 3780
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3780
Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Leu Phe Asp Ser
 1               5                  10                  15      
Ser Tyr Ser Arg Asn
            20      


<210> 3781
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3781
Lys Asn Gly Thr Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp
 1               5                  10                  15      
Ser Tyr Leu Asn Phe Thr Lys Ile
            20                  


<210> 3782
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3782
Lys Ile Val Thr Pro Glu Glu Tyr Tyr Asn Val Thr Val Gln
 1               5                  10                  


<210> 3783
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3783
Lys Gln Val Ala Leu Gln Thr Phe Gly Asn Gln Thr Thr Ile Ile Pro
 1               5                  10                  15      
Ala Gly Gly Ala Gly Tyr Lys Val
            20                  


<210> 3784
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3784
Arg Tyr His Tyr Asn Gly Thr Phe Leu Asp Gly Thr Leu Phe Asp Ser
 1               5                  10                  15      
Ser His Asn Arg Met
            20      


<210> 3785
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3785
Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp Ser
 1               5                  10                  15      
Ser Tyr Ser Arg Asn
            20      


<210> 3786
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3786
Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys
 1               5                  10              


<210> 3787
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3787
Lys Asn Met Thr Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn
 1               5                  10                  15      
Arg Ser
        


<210> 3788
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3788
Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe
 1               5                  10                  15      
Gly Phe Tyr Arg Ser
            20      


<210> 3789
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3789
Lys Val Val Ala Asn Gly Thr Gly Thr Gln Gly Gln Leu Lys Val
 1               5                  10                  15  


<210> 3790
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3790
Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg Val
 1               5                  10      


<210> 3791
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3791
Lys Ile Phe Ile Phe Asn Gln Thr Gly Ile Glu Ala Lys Lys
 1               5                  10                  


<210> 3792
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3792
Arg Gly Leu Val Met Asn Tyr Pro His Ile Thr Asn Leu Thr Asn Leu
 1               5                  10                  15      
Gly Gln Ser Thr Glu Tyr Arg His
            20                  


<210> 3793
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3793
Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp
 1               5                  10                  


<210> 3794
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3794
Arg Tyr Pro Gln Asp Tyr Gln Phe Tyr Ile Gln Asn Phe Thr Ala Leu
 1               5                  10                  15      
Pro Leu Asn Thr Val Val Pro Pro Gln Arg Gln
            20                  25          


<210> 3795
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3795
Arg Gly Ile Leu Asn Ala Thr Ile Ser Val Ala Glu Ile Asn His Pro
 1               5                  10                  15      
Val Thr Thr Tyr Lys Thr
            20          


<210> 3796
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3796
Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg Asn
 1               5                  10                  


<210> 3797
<211> 36
<212> PRT
<213> Homo sapiens

<400> 3797
Arg Ile Gln Asn Ile Leu Ser Glu Lys Pro Thr Val Thr Thr Val Tyr
 1               5                  10                  15      
Ala Asn Asn Gly Ser Val Leu Gln Gly Ser Ser Val Ala Ser Val Tyr
            20                  25                  30          
Asp Gly Lys Leu
        35      


<210> 3798
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3798
Thr Thr Val Tyr Ala Asn Asn Gly Ser Val Leu Gln Gly Ser Ser Val
 1               5                  10                  15      
Ala Ser Val Tyr Asp Gly Lys Leu
            20                  


<210> 3799
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3799
Arg Ala Ala Cys Ala Val Lys Pro Gln Glu Val Gln Met Val Asn Gly
 1               5                  10                  15      
Thr Ile Thr Asn Pro Ile Asn Gly Lys Ser
            20                  25      


<210> 3800
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3800
Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu Phe Thr
 1               5                  10                  15      
Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala Asn Lys
            20                  25                  30          
Val
    


<210> 3801
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3801
Arg Asn Glu Leu Leu Gly Thr Ala Ser Val Asn Leu Ser Asn Val Leu
 1               5                  10                  15      
Lys Asn Asn Gly Gly Lys Met
            20              


<210> 3802
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3802
Arg Asp Cys Asn Asp Thr Leu Glu Glu Asp Asn Thr Asn Leu Glu Thr
 1               5                  10                  15      
Pro Thr Lys Arg
            20  


<210> 3803
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3803
Lys Met Lys Glu Leu Pro Leu Val Ser Leu Phe Cys Ser Cys Phe Leu
 1               5                  10                  15      
Ala Asp Pro Leu Asn Lys Ser
            20              


<210> 3804
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3804
Lys Arg Phe Pro Thr His Tyr Met Pro Tyr Asn Glu Ser Val Ser Phe
 1               5                  10                  15      
Glu Asp Arg Val
            20  


<210> 3805
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3805
Lys Leu Val Leu Pro Ala Lys Asn Thr Thr Asn Leu Lys Thr
 1               5                  10                  


<210> 3806
<211> 37
<212> PRT
<213> Homo sapiens

<400> 3806
Lys Gly Cys Gly Ile Asn Glu Cys His Asp Pro Ser Ile Ser Gly Cys
 1               5                  10                  15      
Asp His Asn Cys Thr Asp Thr Leu Thr Ser Phe Tyr Cys Ser Cys Arg
            20                  25                  30          
Pro Gly Tyr Lys Leu
        35          


<210> 3807
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3807
Arg Asn Val Ser Thr Gly Asp Val Asn Val Glu Met Asn Ala Ala Pro
 1               5                  10                  15      
Gly Val Asp Leu Thr Gln Leu Leu Asn Asn Met Arg Ser
            20                  25                  


<210> 3808
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3808
Gln Thr Gln Ile Ser Glu Thr Asn Val Ile Leu Ser Met Asp Asn Asn
 1               5                  10                  15      
Arg Ser
        


<210> 3809
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3809
Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Ser
 1               5                  10                  15      
Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu
            20                  25              


<210> 3810
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3810
Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln Ile
 1               5                  10                  15      
Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe
            20                  25              


<210> 3811
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3811
Arg Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu
 1               5                  10          


<210> 3812
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3812
Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp Val His Arg Tyr
 1               5                  10                  15  


<210> 3813
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3813
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln
 1               5                  10                  15      


<210> 3814
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3814
Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys Glu Val Thr
 1               5                  10                  15      
Glu Leu Thr Arg Glu
            20      


<210> 3815
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3815
Phe Ser Tyr Val Asn Gly Ser Gly Ala Tyr Ala Lys Asp
 1               5                  10              


<210> 3816
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3816
Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys Val
 1               5                  10                  15      


<210> 3817
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3817
Arg Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys
 1               5                  10                  15      
Gly
    


<210> 3818
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3818
Lys Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys
 1               5                  10                  15  


<210> 3819
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3819
Lys Asn Met Ser Phe Val Asn Asp Leu Thr Val Thr Gln Asp Gly Arg
 1               5                  10                  15      
Lys
    


<210> 3820
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3820
Arg Asp Leu Gln Ala Pro Leu Gly Gln Ser Phe Ser Cys Ser Asn Ser
 1               5                  10                  15      
Ser Ile Ile Leu Ser Pro Ala Val His Leu Asp Leu Leu Ser Leu Arg
            20                  25                  30          
Leu
    


<210> 3821
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3821
Arg Asn Pro Asn Pro Ser Ala Pro Arg Glu
 1               5                  10  


<210> 3822
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3822
Arg Asp Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser
 1               5                  10              


<210> 3823
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3823
Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp
 1               5                  10                  15      
Pro Arg Thr
            


<210> 3824
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3824
Lys Asp Leu Cys Gly Pro Asp Ala Gly Pro Ile Gly Asn Ala Thr Gly
 1               5                  10                  15      
Gln Ala Asp Cys Lys Ala
            20          


<210> 3825
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3825
Lys Asp Met Ser Asp Gly Phe Ile Ser Asn Leu Thr Ile Gln Arg Gln
 1               5                  10                  15      


<210> 3826
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3826
Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu His Asn
 1               5                  10                  15      
Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu
            20                  25      


<210> 3827
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3827
Arg Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala
 1               5                  10                  15      
Met Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp
            20                  25          


<210> 3828
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3828
Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn Ile Thr Val Cys
 1               5                  10                  15      
Glu Gln Lys Ile
            20  


<210> 3829
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3829
Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp
 1               5                  10                  15      


<210> 3830
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3830
Lys His Leu Leu Glu Asn Ser Thr Ala Ser Val Ser Glu Ala Glu Arg
 1               5                  10                  15      
Lys
    


<210> 3831
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3831
Arg Ser Thr Tyr Asn Asp Thr Glu Asp Val Ser Gln Ala Ser Pro Ser
 1               5                  10                  15      
Glu Ser Glu Ala Arg Phe
            20          


<210> 3832
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3832
Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val
 1               5                  10                  15      
Leu Thr Asn Ser Pro Val Glu Leu Arg Glu
            20                  25      


<210> 3833
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3833
Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn
 1               5                  10                  15      
Thr Ser Ala Pro Tyr Gln
            20          


<210> 3834
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3834
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro
 1               5                  10                  15      
Val Lys Gly
            


<210> 3835
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3835
Tyr Leu Arg Pro Gly Gln Ala Ala Ala Phe Asn Val Thr Phe Arg Arg
 1               5                  10                  15      


<210> 3836
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3836
Lys Gly Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr
 1               5                  10                  15      
Val Met Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala
            20                  25                  


<210> 3837
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3837
Lys Ser Val Glu Phe Thr Phe Cys Asn Asp Thr Val Val Ile Pro Cys
 1               5                  10                  15      
Phe Val Thr Asn Met Glu Ala Gln Asn Thr Thr Glu Val Tyr Val Lys
            20                  25                  30          
Trp
    


<210> 3838
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3838
Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr
 1               5                  10                  


<210> 3839
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3839
Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly
 1               5                  10                  15      
Asn Leu Thr Leu Glu Gly Val Thr Arg Gly
            20                  25      


<210> 3840
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3840
Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys
 1               5                  10                  15      
Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys
            20                  25                  30          


<210> 3841
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3841
Arg Ile Val Asp Val Asn Leu Thr Ser Glu Gly Lys Val
 1               5                  10              


<210> 3842
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3842
Lys Gly Gln Thr Glu Ile Gln Val Asn Cys Pro Pro Ala Val Thr Glu
 1               5                  10                  15      
Asn Lys Thr
            


<210> 3843
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3843
Lys Gln Leu Val Leu Asn Leu Thr Gly Asn Thr Leu Cys Ala Gly Gly
 1               5                  10                  15      
Ala Ser Asp Glu Lys Leu
            20          


<210> 3844
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3844
Arg Ile His Tyr Leu Tyr Leu Gln Asn Asn Phe Ile Thr Glu Leu Pro
 1               5                  10                  15      
Val Glu Ser Phe Gln Asn Ala Thr Gly Leu Arg Trp
            20                  25              


<210> 3845
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3845
Lys His Ser Asn Cys Thr His Gln Gln Asp Ala Gly Val Thr Cys Ser
 1               5                  10                  15      
Asp Gly Ser Asn Leu Glu Met Arg Leu
            20                  25  


<210> 3846
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3846
Arg Glu Leu Phe Asn Ile Thr Asn Gly Ala Arg Lys
 1               5                  10          


<210> 3847
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3847
Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln Arg
 1               5                  10                  15      
Met
    


<210> 3848
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3848
Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln Ile
 1               5                  10                  15      
Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe
            20                  25              


<210> 3849
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3849
Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln Arg
 1               5                  10                  15      
Met
    


<210> 3850
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3850
Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly Thr Ile
 1               5                  10                  15      
Val Glu Lys Tyr
            20  


<210> 3851
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3851
Leu Asn Val Tyr Tyr Asn Tyr Ser Gly Gln Val Lys Cys
 1               5                  10              


<210> 3852
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3852
Lys Asn Ile Thr Ile Val Thr Gly Ala Pro Arg His
 1               5                  10          


<210> 3853
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3853
Arg Phe Thr Phe Thr Ser His Thr Pro Gly Asp His Gln Ile Cys Leu
 1               5                  10                  15      
His Ser Asn Ser Thr Arg Met
            20              


<210> 3854
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3854
Arg Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met
 1               5                  10                  15      


<210> 3855
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3855
Lys Gly Trp Asn Trp Thr Ser Gly Phe Asn Lys Cys
 1               5                  10          


<210> 3856
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3856
Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu Asn Ser Ser His Pro
 1               5                  10                  15      
Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile Arg Glu
            20                  25                  


<210> 3857
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3857
Arg Leu Gln Val Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser
 1               5                  10                  15      


<210> 3858
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3858
Ile Ser Val Val Val His Leu Ala Asp Phe Asn Ser Ser Trp Arg Asp
 1               5                  10                  15      
Ala Met
        


<210> 3859
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3859
Arg Glu Asp Ala Gln Ile Asn Thr Thr Ile Gly Ser Val Thr Ala Gln
 1               5                  10                  15      
Asp Pro Asp Ala Ala Arg Asn
            20              


<210> 3860
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3860
Lys Ala Asn Thr Thr Gln Pro Gly Ile Val Glu Gly Gly Gln Val Leu
 1               5                  10                  15      
Lys Cys
        


<210> 3861
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3861
Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr Thr Gly Asn Ile Ser
 1               5                  10                  15      
Ser Phe Gln Gln Cys Tyr Ile Phe Asp
            20                  25  


<210> 3862
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3862
Arg Val Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp
 1               5                  10                  15  


<210> 3863
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3863
Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn Gly Glu Cys Val
 1               5                  10                  15      
Cys Gly Gln Cys Val Cys Arg Lys
            20                  


<210> 3864
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3864
Ala Leu Pro Glu Ile Cys Thr Gln Cys Pro Gly Ser Val Gln Asn Leu
 1               5                  10                  15      
Ser Lys Val
            


<210> 3865
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3865
Lys Phe Tyr Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu
 1               5                  10                  15      
Ala Leu Gln Asp Phe Phe Arg Leu
            20                  


<210> 3866
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3866
Arg Leu Ala Asn Tyr Thr Gly Gly Ile Tyr Ala Glu
 1               5                  10          


<210> 3867
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3867
Arg Thr Ile Leu Val Asp Asn Asn Thr Trp Asn Asn Thr His Ile Ser
 1               5                  10                  15      
Arg Val
        


<210> 3868
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3868
Arg Ser Tyr Ser Thr Thr Tyr Glu Glu Arg Asn Ile Thr Gly Thr Arg
 1               5                  10                  15      
Val
    


<210> 3869
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3869
Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr
 1               5                  10              


<210> 3870
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3870
Arg Gln Asn Ile Val Asn Ala Thr Ala Asn Leu Gly Gln Ser Val Thr
 1               5                  10                  15      
Leu
    


<210> 3871
<211> 25
<212> PRT
<213> Homo sapiens

<400> 3871
Tyr Trp Thr Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala
 1               5                  10                  15      
Gln Gln Gly Glu Glu Val Leu Arg Gln
            20                  25  


<210> 3872
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3872
Arg Asn His Thr Met Val Thr Glu Phe Ile Leu Leu Gly Ile Pro Glu
 1               5                  10                  15      
Thr Glu Gly Leu
            20  


<210> 3873
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3873
Lys Asn Ser Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu
 1               5                  10                  15      
Lys Val
        


<210> 3874
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3874
Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu Lys Ala
 1               5                  10                  15      


<210> 3875
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3875
Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg Phe
 1               5                  10                  15      


<210> 3876
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3876
Arg Val Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn
 1               5                  10                  15      
Val Thr Val Val Thr
            20      


<210> 3877
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3877
Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser Gly Glu Met
 1               5                  10                  15      
Gln Lys Val
            


<210> 3878
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3878
Arg Ile Thr Ser Ala Ser Val Asn Asp Ser Gly Glu Tyr Arg Cys
 1               5                  10                  15  


<210> 3879
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3879
Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys Arg Leu
 1               5                  10              


<210> 3880
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3880
Met Lys Ala Gly Asn Phe Ser Asp Thr Pro Glu Phe Phe Leu Leu Gly
 1               5                  10                  15      
Leu
    


<210> 3881
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3881
Arg Ile Gln Asn Leu Arg Gln Met Asn Glu Thr Ser Pro Asp Asn Val
 1               5                  10                  15      
Cys Tyr Glu Gly Gln Ser Ala Tyr Asp Val Ala Asp Leu Leu Lys Gln
            20                  25                  30          


<210> 3882
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3882
Arg Glu Leu Gln Cys Gln Ile Ser Asp Thr Ser Ala Val Leu Ser Met
 1               5                  10                  15      
Asp Asn Ser Ser Leu Asp Met
            20              


<210> 3883
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3883
Lys Asn Ala Ser Pro Ala Gly Asp Glu Asp Ser Ser Asp Ser Pro Asp
 1               5                  10                  15      
Ser Glu Val Gly Val Lys Ala
            20              


<210> 3884
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3884
Gln Ile Gln Ala Leu Asn Met Ser Ser Cys Pro Leu Asp Ser Lys Gly
 1               5                  10                  15      


<210> 3885
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3885
Arg Leu Gly Phe Leu Gly Asn Gln Ser Gln Gly Cys Leu Pro Ala Arg
 1               5                  10                  15      
Thr
    


<210> 3886
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3886
Arg His His Met Tyr Thr Asn Val Ser Gly Leu Thr Ser Phe Gly Glu
 1               5                  10                  15      
Lys Val
        


<210> 3887
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3887
Lys Tyr Leu Asn Phe Thr Ala Ser Glu Asn Thr Ser Arg Val
 1               5                  10                  


<210> 3888
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3888
Lys Arg Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val
 1               5                  10              


<210> 3889
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3889
Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro
 1               5                  10                  15      
Asp Asn Thr Ser Val Pro Thr Ala Lys Phe
            20                  25      


<210> 3890
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3890
Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln
 1               5                  10                  15      
Thr Ser Leu Ser Asp Pro Val His Leu Thr Val
            20                  25          


<210> 3891
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3891
Arg Leu Leu Leu Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg
 1               5                  10                  15      
Thr
    


<210> 3892
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3892
Ser Gly Ser Asn Phe Thr Ile Gln Asp Asn Lys Asp
 1               5                  10          


<210> 3893
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3893
Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly
 1               5                  10          


<210> 3894
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3894
Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln
 1               5                  10      


<210> 3895
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3895
Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met Lys Gln
 1               5                  10                  15  


<210> 3896
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3896
Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg Phe
 1               5                  10                  15      


<210> 3897
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3897
Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr
 1               5                  10      


<210> 3898
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3898
Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile
 1               5                  10                  15      


<210> 3899
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3899
Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val Asp Phe Gly Thr
 1               5                  10                  15      
Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg Lys
            20                  25                  


<210> 3900
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3900
Arg Tyr Ser Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr
 1               5                  10                  15      
His Leu Phe Pro Asn Ala Ser Ser Lys Glu
            20                  25      


<210> 3901
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3901
Arg Thr Gln Asp Glu Ile Leu Phe Ser Asn Ser Thr Arg Leu
 1               5                  10                  


<210> 3902
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3902
Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly Thr Val Leu Lys Met
 1               5                  10                  15      


<210> 3903
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3903
Arg Glu Leu Ala Val Pro Asp Gly Tyr Thr Asn Arg Thr
 1               5                  10              


<210> 3904
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3904
Lys Glu Ile Phe Val Ala Asn Gly Thr Gln Gly Lys Leu
 1               5                  10              


<210> 3905
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3905
Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly
 1               5                  10                  15      


<210> 3906
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3906
Arg Glu Ala Ser Ile Val Gly Glu Asn Glu Thr Tyr Pro Arg Ala
 1               5                  10                  15  


<210> 3907
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3907
Arg Tyr Val Gln Asn Gly Thr Tyr Thr Val Lys Ile
 1               5                  10          


<210> 3908
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3908
Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr
 1               5                  10      


<210> 3909
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3909
Arg Asp Ile Asn Ser Gln Gln Glu Leu Gln Asn Ile Thr Thr Asp Thr
 1               5                  10                  15      
Arg Phe
        


<210> 3910
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3910
Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu Thr Gln Val Arg
 1               5                  10                  15      
Pro Arg Asn
            


<210> 3911
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3911
Lys Thr Cys Asn Pro Glu Thr Phe Pro Ser Ser Asn Glu Ser Arg Gln
 1               5                  10                  15      


<210> 3912
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3912
Arg Phe Ile Asn Tyr Asn Gln Thr Val Ser Arg Met
 1               5                  10          


<210> 3913
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3913
Tyr Ile Ser Val Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Ser
 1               5                  10                  15      
Lys Asp
        


<210> 3914
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3914
Arg Val Pro Pro Met Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly
 1               5                  10                  15      
Asn Ile Thr Val Thr Cys Arg Ala
            20                  


<210> 3915
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3915
Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg
 1               5                  10                  


<210> 3916
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3916
Ala Ala Leu Pro Pro Ala Pro Gly Thr Glu Leu Ser Tyr Leu Asn Gly
 1               5                  10                  15      
Thr Phe Arg Leu
            20  


<210> 3917
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3917
Lys Asp Tyr Tyr Pro Ile Asn Glu Ser Leu Ala Ser Leu Pro Leu Arg
 1               5                  10                  15      
Val
    


<210> 3918
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3918
Lys Asp Glu Gly Leu Cys Ser Ala Asn Val Thr Arg Tyr
 1               5                  10              


<210> 3919
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3919
Lys Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala Gly
 1               5                  10                  15      
Gln Gly Glu Arg Asp
            20      


<210> 3920
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3920
Tyr Phe Met Asn Leu Ser Gln Ala Asn Ala Gln Gly Thr Pro Arg Trp
 1               5                  10                  15      


<210> 3921
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3921
Arg Asp Asp Ala Gly Asn Tyr Thr Cys Ile Ala Ser Asn Gly Pro Gln
 1               5                  10                  15      
Gly Gln Ile Arg Ala
            20      


<210> 3922
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3922
Lys Asn Ile Thr Asp Leu Val Glu Gly Ala Lys Lys
 1               5                  10          


<210> 3923
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3923
Lys Gly Glu Tyr Phe Val Asn Val Thr Thr Arg Ile
 1               5                  10          


<210> 3924
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3924
Arg Ser Ala Glu Phe Phe Asn Tyr Thr Val Arg Thr
 1               5                  10          


<210> 3925
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3925
Arg Tyr Asn Cys Ser Ile Glu Ser Pro Arg Lys
 1               5                  10      


<210> 3926
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3926
Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn
 1               5                  10          


<210> 3927
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3927
Gln Asn Ala Thr Val Glu Ala Gly Thr Arg Cys
 1               5                  10      


<210> 3928
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3928
Arg Ala Leu Val Asn Phe Thr Arg Ser
 1               5                  


<210> 3929
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3929
Arg Glu Gln Gln Leu Glu Ser Cys Ala Cys Asn Glu Thr Asp Asn Ser
 1               5                  10                  15      
Cys Lys Val
            


<210> 3930
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3930
Lys Phe Val Asn Ser Thr Gly Tyr Leu Thr Glu Ala Glu Lys Phe
 1               5                  10                  15  


<210> 3931
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3931
Arg Arg Pro Pro Leu Ala Glu Leu Ala Ala Leu Asn Leu Ser Gly Ser
 1               5                  10                  15      
Arg Leu
        


<210> 3932
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3932
Lys Thr Tyr Asn Ala Ser Val Leu Pro Val Arg Val
 1               5                  10          


<210> 3933
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3933
Arg Val Leu Gln Gln Gly Ala Pro Gly Cys Ala Leu Val Leu Asp Thr
 1               5                  10                  15      
Met Ala Asn Ser Ser Ser Ser Ala Tyr Gly Ala Tyr Phe Glu Arg Leu
            20                  25                  30          


<210> 3934
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3934
Arg Thr Asn Gln Asp Ile Pro Ala Pro Ala Asn Phe Ser Gln Arg Gly
 1               5                  10                  15      


<210> 3935
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3935
Lys Tyr Phe Asn Tyr Thr Val Lys Val
 1               5                  


<210> 3936
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3936
Arg Thr Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn
 1               5                  10                  15      
Thr Ser Ala Pro Arg Gln
            20          


<210> 3937
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3937
Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala Ala Pro Gly Gln
 1               5                  10                  15      
Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp Asp Gly Arg Ser
            20                  25                  30          


<210> 3938
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3938
Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu
 1               5                  10                  15  


<210> 3939
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3939
Lys Asn Ile Asn Gly Thr Asp Pro Ile Gln Lys Tyr
 1               5                  10          


<210> 3940
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3940
Lys Leu Asp Asn Tyr Ser Thr Gln Glu Leu Gly Lys Thr
 1               5                  10              


<210> 3941
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3941
Lys Asp Leu Val Val Gln Gln Ala Gly Thr Asn Lys Thr
 1               5                  10              


<210> 3942
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3942
Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg
 1               5                  10                  


<210> 3943
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3943
Lys Thr Phe Lys Asn Glu Ser Glu Asn Thr Cys Gln Asp Val Asp Glu
 1               5                  10                  15      
Cys Gln Gln Asn Pro Arg Leu
            20              


<210> 3944
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3944
Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu Asn Leu Ala Ser
 1               5                  10                  15      
Trp Arg Glu
            


<210> 3945
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3945
Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu
 1               5                  10          


<210> 3946
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3946
Arg Leu Leu Glu Thr Val Glu Tyr Asn Ile Ser Gly Ala Glu Arg Thr
 1               5                  10                  15      


<210> 3947
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3947
Arg His Met Pro Trp Asn Ile Thr Arg Met
 1               5                  10  


<210> 3948
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3948
Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val
 1               5                  10          


<210> 3949
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3949
Lys Ser Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val
 1               5                  10              


<210> 3950
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3950
Arg Ile Val Asn Glu Thr Leu Tyr Glu Asn Thr Lys Leu
 1               5                  10              


<210> 3951
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3951
Arg Val Leu Glu Ala Val Asn Gly Thr Asp Ala Arg Leu
 1               5                  10              


<210> 3952
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3952
Ala Lys Asn Tyr Ser Val Leu Tyr Phe Gln Gln Lys Val
 1               5                  10              


<210> 3953
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3953
Val Pro Tyr Ala Asn His Ser Ser Phe Arg Ser
 1               5                  10      


<210> 3954
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3954
Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly
 1               5                  10                  15      
Pro Met Met Gly Gly Asn
            20          


<210> 3955
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3955
Arg Val Gly Leu Ile Gly Ser Cys Thr Asn Ser Ser Tyr Glu Asp Met
 1               5                  10                  15      
Gly Arg Ser
            


<210> 3956
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3956
Arg Arg Asn Ser Ser Ser Ser Met Ser Ser Arg Leu
 1               5                  10          


<210> 3957
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3957
Arg Phe Ser Asn Leu Leu Asn Val Ser Thr Trp Gly Ile Leu Cys Asn
 1               5                  10                  15      
Leu Cys Asn Ser Pro Arg Ser Phe Pro Lys Lys Gly
            20                  25              


<210> 3958
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3958
Gln Ser Asn Leu Thr Asp Met Arg Cys Arg Thr Thr Phe Tyr Thr Ala
 1               5                  10                  15      
Leu Gly Arg Leu Leu
            20      


<210> 3959
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3959
Met Leu Lys Ser Pro Phe Ala Gly Ser Gly Ile Leu Ala Ala Thr Asn
 1               5                  10                  15      
Ser Thr Glu Leu
            20  


<210> 3960
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3960
Met Leu Asp Thr Trp Asn Glu Ser Ile Phe Ser Asn Ile Lys Asn Arg
 1               5                  10                  15      
Leu
    


<210> 3961
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3961
Lys Trp Pro Thr Asn Thr Thr Met Arg Thr
 1               5                  10  


<210> 3962
<211> 32
<212> PRT
<213> Homo sapiens

<400> 3962
Lys Val Phe Leu Ala Thr Asn Ser Ser Tyr Asn Tyr Thr Asn Ala Ile
 1               5                  10                  15      
Met Thr Tyr Leu Phe Ser Ile Ser Glu Ala Glu Ala Ser Gly Arg Pro
            20                  25                  30          


<210> 3963
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3963
Lys Asn Gly Asp Ala Tyr Gly Phe Tyr Asn Asn Ser Val Lys Thr
 1               5                  10                  15  


<210> 3964
<211> 20
<212> PRT
<213> Homo sapiens

<400> 3964
Lys Asn Met Ser Asn Leu Arg Thr Trp Leu Ala Arg Ile Glu Ser Glu
 1               5                  10                  15      
Leu Ser Lys Pro
            20  


<210> 3965
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3965
Lys Asn Phe Ser Glu Ile His Pro Gly Met Leu Leu Ile Gly Phe Val
 1               5                  10                  15      
Lys Ser
        


<210> 3966
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3966
Lys Met Leu Met Glu Leu Ser Ala Gly Ala Ala Asn Phe Thr Asp Gln
 1               5                  10                  15      
Lys Glu
        


<210> 3967
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3967
Lys Ile Tyr Asn Trp Ser Gly Tyr Pro Leu Leu Val Gln Lys Leu
 1               5                  10                  15  


<210> 3968
<211> 31
<212> PRT
<213> Homo sapiens

<400> 3968
Lys Asp Ser Leu Asn Glu Met Phe Pro Ser Ala Ile Leu Asn Gly Thr
 1               5                  10                  15      
Gly Ser Pro Thr Lys Phe Lys Met Pro Phe Asn Asn Ala Lys Lys
            20                  25                  30      


<210> 3969
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3969
Lys Ala Lys Ser Glu Glu Asn Gln Gly Asp Asn Ser Ser Glu Asn Gly
 1               5                  10                  15      
Asn Gly Lys Glu Lys Ile Arg Ile
            20                  


<210> 3970
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3970
Lys Ala Ile Phe Ser His Ala Ala Gly Asp Asn Ser Thr Leu Leu Ser
 1               5                  10                  15      
Phe Lys Glu
            


<210> 3971
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3971
Gly Met Glu Gly Asp Phe Asn Ala Ser Ser Gly Trp Leu Thr Arg Phe
 1               5                  10                  15      
Lys Gln
        


<210> 3972
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3972
Asp Phe Lys Leu Ser Gly Pro Ser Asn Ser Ser Met Glu Asp Phe Thr
 1               5                  10                  15      
Lys Arg Ser
            


<210> 3973
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3973
Val Met Ile Pro Pro Asn Asp Ser Arg Ala Arg Ser
 1               5                  10          


<210> 3974
<211> 17
<212> PRT
<213> Homo sapiens

<400> 3974
Arg Val Gln Cys Ser Pro Gly His Phe Tyr Asn Thr Thr Thr His Arg
 1               5                  10                  15      
Cys
    


<210> 3975
<211> 26
<212> PRT
<213> Homo sapiens

<400> 3975
Arg Ser Ala Cys Asn Cys Thr Ala Gly Ala Ala Cys Asp Ala Val Asn
 1               5                  10                  15      
Gly Ser Cys Leu Cys Pro Ala Gly Arg Arg
            20                  25      


<210> 3976
<211> 18
<212> PRT
<213> Homo sapiens

<400> 3976
Arg Asp Gln Leu Met Thr Val Leu Ala Asn Val Thr His Leu Leu Ile
 1               5                  10                  15      
Arg Ala
        


<210> 3977
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3977
Met Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln
 1               5                  10          


<210> 3978
<211> 33
<212> PRT
<213> Homo sapiens

<400> 3978
Phe Met Leu Glu Asn Gly Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro
 1               5                  10                  15      
Leu Phe Ile Ala Cys Gly Gly Gln Gln Asn His Thr Gln Gly Ser Lys
            20                  25                  30          
Met
    


<210> 3979
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3979
Arg Val Gln Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu
 1               5                  10                  15  


<210> 3980
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3980
Leu Thr Gly Glu Leu His Asp Gly Val Ser Lys Ala Asn Phe Ser Ile
 1               5                  10                  15      
Gly Arg Met Thr Gln Asp Leu Ala Gly Thr Tyr Arg Cys Tyr
            20                  25                  30  


<210> 3981
<211> 28
<212> PRT
<213> Homo sapiens

<400> 3981
Lys Arg Gly Thr Phe Ile Glu Phe Arg Asn Gly Met Leu Asn Val Ser
 1               5                  10                  15      
Pro Ile Gly Arg Ser Cys Ser Gln Glu Glu Arg Ile
            20                  25              


<210> 3982
<211> 27
<212> PRT
<213> Homo sapiens

<400> 3982
Tyr Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly
 1               5                  10                  15      
Thr Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln
            20                  25          


<210> 3983
<211> 22
<212> PRT
<213> Homo sapiens

<400> 3983
Trp Ile Val Gly Asn Trp Ser Glu Cys Ser Thr Thr Cys Gly Leu Gly
 1               5                  10                  15      
Ala Tyr Trp Lys Arg Val
            20          


<210> 3984
<211> 23
<212> PRT
<213> Homo sapiens

<400> 3984
Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser Gly Ala Leu Leu Cys
 1               5                  10                  15      
Ser Gln Ala Leu Cys Ser Gly
            20              


<210> 3985
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3985
Arg Trp Lys Ser Ala Asn Phe Ser Gly Val Lys Tyr
 1               5                  10          


<210> 3986
<211> 12
<212> PRT
<213> Homo sapiens

<400> 3986
Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg
 1               5                  10          


<210> 3987
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3987
Arg Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe Pro Ala Ala Cys
 1               5                  10                  15      
Ile Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr Arg Cys
            20                  25                  30  


<210> 3988
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3988
Arg Met Cys Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Glu
 1               5                  10                  15      
Gly Leu Asn Ser Ser Gln Lys Leu
            20                  


<210> 3989
<211> 19
<212> PRT
<213> Homo sapiens

<400> 3989
Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn Gly Thr
 1               5                  10                  15      
Glu Arg Val
            


<210> 3990
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3990
Lys Tyr Val Gly Ala Thr Phe Pro Gly Thr Val Cys Asn Lys Ser
 1               5                  10                  15  


<210> 3991
<211> 29
<212> PRT
<213> Homo sapiens

<400> 3991
Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr Pro Glu Gly
 1               5                  10                  15      
Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp
            20                  25                  


<210> 3992
<211> 10
<212> PRT
<213> Homo sapiens

<400> 3992
Lys Ser Thr Phe Ile Asn Met Thr Arg Val
 1               5                  10  


<210> 3993
<211> 24
<212> PRT
<213> Homo sapiens

<400> 3993
Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg
 1               5                  10                  15      
Ala Gly Met Phe Val Ser Lys Phe
            20                  


<210> 3994
<211> 13
<212> PRT
<213> Homo sapiens

<400> 3994
Lys His Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val
 1               5                  10              


<210> 3995
<211> 15
<212> PRT
<213> Homo sapiens

<400> 3995
Lys Phe Asn Leu Thr Asn Cys Cys Leu Gln Ile Asp Asp Gln Gly
 1               5                  10                  15  


<210> 3996
<211> 16
<212> PRT
<213> Homo sapiens

<400> 3996
Lys Cys His Glu Gly Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys
 1               5                  10                  15      


<210> 3997
<211> 30
<212> PRT
<213> Homo sapiens

<400> 3997
Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser Gly Ile Pro Asp Leu
 1               5                  10                  15      
Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp Thr Lys Gly
            20                  25                  30  


<210> 3998
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3998
Ser Glu Ile Cys Gly Ala Asn His Ser
 1               5                  


<210> 3999
<211> 34
<212> PRT
<213> Homo sapiens

<400> 3999
Arg Lys Glu Asn Ser Thr Leu Gln Glu Met Asn Ser Thr Thr Glu Ser
 1               5                  10                  15      
Asn Ile Ile Leu Ser Asn Val Ser Val Gly Ala Ile Thr Glu Ala Thr
            20                  25                  30          
Lys Met
        


<210> 4000
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4000
Met Ile Thr Ala Val Gly Leu Ser Asn Leu Gln Phe Val Asp Met Asn
 1               5                  10                  15      
Ser Ser Arg Asn
            20  


<210> 4001
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4001
Lys Glu Asn Ser Ala Phe Pro Pro Phe Cys Cys Asn Asp Asn Val Thr
 1               5                  10                  15      
Asn Thr Ala Asn Glu Thr Cys Thr Lys Gln Lys Ala
            20                  25              


<210> 4002
<211> 36
<212> PRT
<213> Homo sapiens

<400> 4002
Lys Asp Lys Val Ala Val Leu Ser Val Asp Asp Cys Asp Val Ala Val
 1               5                  10                  15      
Ala Leu Gln Phe Gly Ala Glu Ile Gly Asn Tyr Ser Cys Ala Ala Ala
            20                  25                  30          
Gly Val Gln Thr
        35      


<210> 4003
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4003
His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr
 1               5                  10                  15      
Asp Tyr Tyr Gln Glu Leu Gln Arg Asp
            20                  25  


<210> 4004
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4004
Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp Ala Glu Asp Lys Gly
 1               5                  10                  15  


<210> 4005
<211> 37
<212> PRT
<213> Homo sapiens

<400> 4005
Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp
 1               5                  10                  15      
Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro
            20                  25                  30          
Gly Gly Leu Arg Glu
        35          


<210> 4006
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4006
Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys
 1               5                  10                  


<210> 4007
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4007
Gln Phe Gly Met Asn Ala Ser Ser Ser Arg Phe
 1               5                  10      


<210> 4008
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4008
Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly
 1               5                  10              


<210> 4009
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4009
Lys Phe Val Glu Gln Asn Glu Thr Ala Ile Asn Ile Thr Thr Tyr Pro
 1               5                  10                  15      
Asp Gln Glu Asn Asn Lys Leu
            20              


<210> 4010
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4010
Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg Asp
 1               5                  10                  


<210> 4011
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4011
Lys Cys Ala Thr Val Thr Glu Asn Ala Thr Gly Asp Leu Ala Thr Ser
 1               5                  10                  15      
Arg Asn
        


<210> 4012
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4012
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
 1               5                  10                  15      
Ser Leu Leu Glu Ser Asn Lys Asp
            20                  


<210> 4013
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4013
Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
 1               5                  10              


<210> 4014
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4014
Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp
 1               5                  10  


<210> 4015
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4015
Lys Gly Ser Asn Tyr Ser Glu Ile Leu Asp Lys Tyr
 1               5                  10          


<210> 4016
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4016
Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu
 1               5                  10              


<210> 4017
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4017
Val Phe Glu Phe Asn Gly Thr Gln Ala Val Arg Ile
 1               5                  10          


<210> 4018
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4018
Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser Thr Leu
 1               5                  10              


<210> 4019
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4019
Ala Leu Ala Asn Leu Thr Gly Thr Val Val Asn Leu Thr Arg Glu
 1               5                  10                  15  


<210> 4020
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4020
Arg Trp Trp Tyr Asn Val Thr Asp Gly Ser
 1               5                  10  


<210> 4021
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4021
Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp Tyr Val Asp
 1               5                  10                  15      
Pro Val Thr Asn Gln Thr Lys Thr
            20                  


<210> 4022
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4022
Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro
 1               5                  10                  15      
Ser Lys Glu
            


<210> 4023
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4023
Arg Tyr Ala Val Tyr Trp Asn Ser Ser Asn Pro Arg Phe
 1               5                  10              


<210> 4024
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4024
Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg
 1               5                  10              


<210> 4025
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4025
Lys Gly Pro Leu Ala Asn Pro Ile Trp Asn Val Thr Gly Phe Thr Gly
 1               5                  10                  15      
Arg Asp
        


<210> 4026
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4026
Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile Ala Leu
 1               5                  10                  


<210> 4027
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4027
Lys Gln Asp Gln Gln Leu Gln Asn Cys Thr Glu Pro Gly Glu Gln Pro
 1               5                  10                  15      
Ser Pro Lys Gln
            20  


<210> 4028
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4028
Lys Asp Ile Trp Asn Val Thr Gly Ala Gln
 1               5                  10  


<210> 4029
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4029
Arg Ile Phe Asn Ile Asp Ser Gly Asn Gly Ser Ile Phe Thr Ser Lys
 1               5                  10                  15      
Leu
    


<210> 4030
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4030
Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu
 1               5                  10          


<210> 4031
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4031
Met Gly Leu Gln Leu Asn Ile Thr Gln Asp Lys Val
 1               5                  10          


<210> 4032
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4032
Lys Val Asn Glu Thr Glu Met Asp Ile Ala Lys His
 1               5                  10          


<210> 4033
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4033
Lys His Leu Asn Gly Thr Ile Thr Ala Lys Tyr
 1               5                  10      


<210> 4034
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4034
Arg Asn Phe Pro Asp Ala Phe Glu Tyr Asn Asn Val Ser Arg Gln
 1               5                  10                  15  


<210> 4035
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4035
Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu
 1               5                  10                  15      
Val Lys Trp
            


<210> 4036
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4036
Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys
 1               5                  10              


<210> 4037
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4037
Lys Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala
 1               5                  10                  15      
Met Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp
            20                  25          


<210> 4038
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4038
Phe Asp Val Thr Asn Leu Ser Gln Asp Met Leu Arg Ser
 1               5                  10              


<210> 4039
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4039
Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly
 1               5                  10                  


<210> 4040
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4040
Lys Asp Leu Asp Thr Asp Phe Thr Asn Asn Ala Ser Gln Pro Glu Thr
 1               5                  10                  15      
Lys Ala
        


<210> 4041
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4041
Arg Tyr His Ser Ser Leu Gly Gln Leu Asn Phe Thr Gly Ser Val Ile
 1               5                  10                  15      
Tyr
    


<210> 4042
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4042
Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser
 1               5                  10              


<210> 4043
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4043
Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr Ile Phe
 1               5                  10                  


<210> 4044
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4044
Tyr Gly Phe Glu Gly Ala Asn Ser Asn Asn Ser Lys Tyr
 1               5                  10              


<210> 4045
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4045
Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr
 1               5                  10      


<210> 4046
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4046
Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr
 1               5                  10          


<210> 4047
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4047
Arg Asp Met Asn Gln Thr Leu Gly Asp Asn Ile Thr Val Lys Met
 1               5                  10                  15  


<210> 4048
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4048
Arg His Thr Val Phe Trp Asn Ser Ser Asn Pro Lys Phe
 1               5                  10              


<210> 4049
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4049
Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr Ser Lys Glu
 1               5                  10              


<210> 4050
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4050
Lys Cys Ser Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu
 1               5                  10                  


<210> 4051
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4051
His His Val Asn Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr
 1               5                  10                  15      
Pro Lys Cys
            


<210> 4052
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4052
Ser Pro Glu Met Asn Ser Thr Ile Asn Ile His Arg Thr
 1               5                  10              


<210> 4053
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4053
Lys Tyr Pro His Asn His His Val Val Asn Asn Thr Leu Glu Gly Asn
 1               5                  10                  15      
Cys Ser Ser Lys Ser
            20      


<210> 4054
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4054
His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser
 1               5                  10      


<210> 4055
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4055
Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe Leu Glu Cys Ser
 1               5                  10                  15      
Pro Lys Ser
            


<210> 4056
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4056
Arg Ala Phe Gly Ile Val Glu Cys Val Leu Cys Thr Cys Asn Val Thr
 1               5                  10                  15      
Lys Gln
        


<210> 4057
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4057
Lys Gln Tyr Leu Ser Tyr Glu Thr Leu Tyr Ala Asn Gly Ser Arg Thr
 1               5                  10                  15      


<210> 4058
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4058
Arg Cys Met Lys Met Ala Tyr Asn Met Thr Phe Phe Pro
 1               5                  10              


<210> 4059
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4059
Lys Leu Pro Ser Gly Met Leu Val Ile Ser Asn Ala Thr Glu Gly Asp
 1               5                  10                  15      
Gly Gly Leu Tyr Arg Cys
            20          


<210> 4060
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4060
Arg Gln Val Val Glu Asn Met Thr Arg Ala
 1               5                  10  


<210> 4061
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4061
Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile
 1               5                  10                  15      
Gly Lys Ser
            


<210> 4062
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4062
Lys Thr Tyr Asn Gly Thr Asn Pro Asp Ala Ala Ser Arg Ala
 1               5                  10                  


<210> 4063
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4063
Arg Gln Gly Ile Asp Phe Cys Pro Gly Gln Asn Val Ser Gly Val Thr
 1               5                  10                  15      


<210> 4064
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4064
Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser
 1               5                  10                  15      
Arg Asn
        


<210> 4065
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4065
Lys Gly Ser Ala Thr Phe Asn Ser Thr Glu Gly Val Leu Gln His
 1               5                  10                  15  


<210> 4066
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4066
Lys Ala Ile Asn Asp Thr Ala Ala Arg Leu
 1               5                  10  


<210> 4067
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4067
Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys Glu
 1               5                  10      


<210> 4068
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4068
Arg Ser Leu Ser Asn Ser Thr Ala Arg Asn
 1               5                  10  


<210> 4069
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4069
Arg Gly Asn Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn
 1               5                  10                  15      
Ala Ser Gln Glu Asp Glu Gly Met Tyr Lys Cys
            20                  25          


<210> 4070
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4070
His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro Pro
 1               5                  10                  15      
Glu Asn Ile Ser Ala Thr Arg Asn
            20                  


<210> 4071
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4071
Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys Ser
 1               5                  10                  


<210> 4072
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4072
Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln Phe Pro Pro
 1               5                  10                  15      
Ser Arg Ser
            


<210> 4073
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4073
Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met
 1               5                  10                  15  


<210> 4074
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4074
Arg Phe Asp Asn Glu Thr Phe Arg Ile
 1               5                  


<210> 4075
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4075
Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu Lys Leu
 1               5                  10              


<210> 4076
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4076
Phe Thr Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe
 1               5                  10                  


<210> 4077
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4077
Arg Lys Phe Asn Ala Thr Glu Arg Glu
 1               5                  


<210> 4078
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4078
Lys Phe Asn Ile Thr Asp Asn Val Met Gln His Leu
 1               5                  10          


<210> 4079
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4079
Lys Asn Trp Gln Leu Thr Glu Glu Asp Phe Gly Asn Thr Ser Gly Arg
 1               5                  10                  15      
Leu
    


<210> 4080
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4080
Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser
 1               5                  10          


<210> 4081
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4081
Tyr Asn Gly Ser Ile Cys Gly Asp Asp Gln Asn Gly Pro Lys Ile
 1               5                  10                  15  


<210> 4082
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4082
Arg Val Gln Gln Val Gly His Tyr Pro Pro Ala Asn Ser Ser Leu Ser
 1               5                  10                  15      
Ser Arg Ser
            


<210> 4083
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4083
Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu
 1               5                  10                  15      
Arg Leu
        


<210> 4084
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4084
Ser Tyr Asn Val Thr Asn Leu Thr Asp Asp Leu Lys Ala
 1               5                  10              


<210> 4085
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4085
Thr Tyr Ile Asn Met Glu Asn Phe Thr Leu Ala Arg Asp
 1               5                  10              


<210> 4086
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4086
Arg Leu Gly Ala Asn Gly Ser His Ile Pro Gln Thr
 1               5                  10          


<210> 4087
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4087
Arg Glu Thr Leu Leu Trp His Asn Ile Thr Val Ile Ala Thr Glu Ile
 1               5                  10                  15      
Asn Asn Pro Lys Gln
            20      


<210> 4088
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4088
Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr
 1               5                  10      


<210> 4089
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4089
Phe Thr Leu Asn Phe Thr Ile Asn Asn Leu Arg Tyr
 1               5                  10          


<210> 4090
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4090
Arg Trp Thr Pro Leu Asn Ser Ser Thr Ile Ile Gly Tyr Arg Ile
 1               5                  10                  15  


<210> 4091
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4091
Lys Glu Ala Ser Gln Asn Ile Thr Tyr Ile Cys Lys Asn
 1               5                  10              


<210> 4092
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4092
Leu Thr Ile Leu Asn Gln Thr Ile Asp Ile Cys Lys His
 1               5                  10              


<210> 4093
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4093
Arg Asn Asn Val Ile Thr Leu Asn Ile Thr Gly Lys Ala
 1               5                  10              


<210> 4094
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4094
Ile Ala Phe Pro Gly Pro Ala Gly Pro Ser Phe Asn Ser Thr Glu Asp
 1               5                  10                  15      
His Ser Lys Trp
            20  


<210> 4095
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4095
Lys Ser Glu Asp Ile Lys Asn Val Ser Arg Leu
 1               5                  10      


<210> 4096
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4096
Lys Ala Asn Ala Thr Ile Glu Val Lys Ala
 1               5                  10  


<210> 4097
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4097
Arg Ile Ala Val Asp Trp Glu Ser Leu Gly Tyr Asn Ile Thr Arg Cys
 1               5                  10                  15      


<210> 4098
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4098
Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala Asn Ala Ser Ala Gln
 1               5                  10                  15      
Gln Pro Arg Thr
            20  


<210> 4099
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4099
Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His
 1               5                  10              


<210> 4100
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4100
Lys Gly His His Val Ser Gln Glu Pro Trp Asn Ser Ser Ile Thr Leu
 1               5                  10                  15      
Thr Ser Gln Ala Gly Ala Val Phe Gln Ser Phe Ala Lys Phe
            20                  25                  30  


<210> 4101
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4101
Arg Asp Glu Ile Gly Asn Val Ser Thr Ser His Leu Leu Ile Leu Asp
 1               5                  10                  15      
Asp Ser Val Glu Met Glu Ile Arg Pro Arg Phe
            20                  25          


<210> 4102
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4102
Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys Ile
 1               5                  10                  


<210> 4103
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4103
Lys Tyr Gln Pro Ile Asn Ser Thr His Glu Leu Gly Pro Leu Val
 1               5                  10                  15  


<210> 4104
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4104
Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp
 1               5                  10      


<210> 4105
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4105
Arg Leu Gly Gly Trp Asn Ile Thr Gly Pro Trp Ala Lys Asp
 1               5                  10                  


<210> 4106
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4106
Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His Asp Asn Gln Thr
 1               5                  10                  15      
Cys Cys Arg Asp
            20  


<210> 4107
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4107
Arg Leu Pro His Asp Cys Phe Gln Asn Ala Thr Asn Ser Phe Tyr Tyr
 1               5                  10                  15      
Asp Val Gly Arg Cys
            20      


<210> 4108
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4108
Arg Phe Ala Asn Glu Tyr Pro Asn Ile Thr Arg Leu
 1               5                  10          


<210> 4109
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4109
Arg His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser
 1               5                  10                  15      
Val Thr Cys
            


<210> 4110
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4110
Arg Leu Gly Asp Val Glu Val Asn Ala Gly Gln Asn Ala Thr Phe Gln
 1               5                  10                  15      
Cys Ile Ala Thr Gly Arg Asp
            20              


<210> 4111
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4111
Tyr Asp Ile Asp Gly Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn
 1               5                  10                  15      
Pro Leu Arg Ile
            20  


<210> 4112
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4112
Tyr Asn Phe Glu Asn Ala Ser Gln Thr Phe Asp Asp Leu Pro Ala Arg
 1               5                  10                  15      
Phe
    


<210> 4113
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4113
Tyr Val Val Thr Ser Asn Met Thr Leu Arg Asp
 1               5                  10      


<210> 4114
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4114
Arg Thr Val Leu Gln Phe Val Thr Asn Leu Thr Lys Glu
 1               5                  10              


<210> 4115
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4115
Arg Gly Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly
 1               5                  10                  15  


<210> 4116
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4116
Lys Val Leu Asn Ser Ser Asn Glu His Val Ile Ser Ile Gly Ala Ser
 1               5                  10                  15      


<210> 4117
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4117
Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr
 1               5                  10                  15      
Pro Gly Gly Arg Val
            20      


<210> 4118
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4118
Arg Gly Leu Leu His Leu Glu Asn Ala Ser Tyr Gly Ile Glu Pro Leu
 1               5                  10                  15      
Gln
    


<210> 4119
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4119
Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly
 1               5                  10                  15  


<210> 4120
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4120
Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly
 1               5                  10                  15      
Ser Leu Gln Gly
            20  


<210> 4121
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4121
Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys Gln
 1               5                  10                  15  


<210> 4122
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4122
Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp Pro
 1               5                  10                  15      
Val Pro Leu Lys Ser
            20      


<210> 4123
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4123
Arg Leu Leu His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp
 1               5                  10                  15      
Leu Asn Met Thr Arg Ser
            20          


<210> 4124
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4124
Ile Asn Thr Thr Gly Thr Leu Lys Pro Asp Asp Arg Val
 1               5                  10              


<210> 4125
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4125
Lys Gln Asn Gly Ser Ala Ser Ser Val Ala Gly Pro Ala Ser Gly Leu
 1               5                  10                  15      
Asp Lys Ser
            


<210> 4126
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4126
Arg Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu
 1               5                  10          


<210> 4127
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4127
Lys Asn Asn Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr
 1               5                  10                  15      
Glu
    


<210> 4128
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4128
Lys Ala Asn Leu Thr Trp Ser Val Lys His
 1               5                  10  


<210> 4129
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4129
Leu Ser Gly Asn Lys Thr Arg Ser
 1               5              


<210> 4130
<211> 31
<212> PRT
<213> Homo sapiens

<400> 4130
Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val Phe Ser Asp
 1               5                  10                  15      
Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr Lys Gly
            20                  25                  30      


<210> 4131
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4131
Arg Leu Ala Ser Ala Phe Gly Asp Pro His Phe Val Thr Phe Asp Gly
 1               5                  10                  15      
Thr Asn Phe Thr Phe Asn Gly Arg Gly
            20                  25  


<210> 4132
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4132
Arg Asn His Ser Gly Gly Gly Gly Gly Gly Gly Ser Gly Ala Ala Ala
 1               5                  10                  15      
Gly Val Gly Ala Ala Ala Ala Ala
            20                  


<210> 4133
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4133
Lys Tyr Ile His Gln Asn Tyr Thr Lys Ala
 1               5                  10  


<210> 4134
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4134
Lys Asn Gly Thr Ser Phe Asp Ile His Tyr
 1               5                  10  


<210> 4135
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4135
Lys Val Phe Val Gln Thr Pro Thr Ile Asn Tyr Thr Leu Arg Asp
 1               5                  10                  15  


<210> 4136
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4136
Arg Ile Leu Cys Asp Asn Ala Asp Asn Ile Thr Arg Val
 1               5                  10              


<210> 4137
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4137
Arg His Val Val Tyr Trp Asn Ser Ser Asn Pro Arg Leu
 1               5                  10              


<210> 4138
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4138
Arg Gly Ala Asn Asp Ser Thr Ser Ala Met Pro Glu Gln Met Lys Phe
 1               5                  10                  15      


<210> 4139
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4139
Lys Ser Ile Val Leu Glu Pro Ile Tyr Trp Asn Ser Ser Asn Ser Lys
 1               5                  10                  15      
Phe
    


<210> 4140
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4140
Lys His Thr Asn Met Asn Leu Thr Gln Leu Lys Val
 1               5                  10          


<210> 4141
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4141
Lys Glu Val Asn Ile Ser Met Tyr Leu Val Asn Gly Ser Val
 1               5                  10                  


<210> 4142
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4142
Lys Glu Val Asn Ile Ser Met Tyr Leu
 1               5                  


<210> 4143
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4143
Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp
 1               5                  10                  15  


<210> 4144
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4144
Val Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val
 1               5                  10                  15      
Asn Lys Ala
            


<210> 4145
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4145
Ser Ser Val Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe
 1               5                  10                  15      
Cys Glu Leu Gly Asn Pro Phe Lys Arg
            20                  25  


<210> 4146
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4146
Arg Ile Pro Glu Ile Ser Asn Ile Thr Thr Thr Pro His Thr
 1               5                  10                  


<210> 4147
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4147
Leu Glu Val Gly Trp Asn Asn Thr Ala Ser Ala Arg Asn
 1               5                  10              


<210> 4148
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4148
Lys Leu Leu Leu Ser Ile Asn Val Thr Asn Thr Arg Thr
 1               5                  10              


<210> 4149
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4149
Lys Gly Ser Trp Leu Leu Gly Asn Ile Asn Gln Thr Gly Tyr Phe Arg
 1               5                  10                  15      
Val
    


<210> 4150
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4150
Arg Ala Leu Ser Asn Ile Ser Leu Arg Leu
 1               5                  10  


<210> 4151
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4151
Arg Lys Thr Asn Glu Ser Val Ser Glu Pro Arg Lys
 1               5                  10          


<210> 4152
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4152
His Ile Pro Glu Ile Asn Asp Ser Ile Arg Ala
 1               5                  10      


<210> 4153
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4153
Lys Gln Leu Val His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala
 1               5                  10                  15      
Tyr Ala Asn Arg Thr
            20      


<210> 4154
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4154
Arg Leu Leu Asn Cys Thr Ala Pro Gly Pro Asp Ala Ala Ala Arg Cys
 1               5                  10                  15      


<210> 4155
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4155
Arg Leu Asn Glu Thr His Ile Phe Asn Gly Ser Asn Trp Ile Met
 1               5                  10                  15  


<210> 4156
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4156
Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp
 1               5                  10                  15      


<210> 4157
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4157
Lys His Gly Asn Leu Thr Val Asp His Ile Gln Asn Asn Ser Asp Ser
 1               5                  10                  15      
Gly
    


<210> 4158
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4158
Leu Glu Leu Phe Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu
 1               5                  10                  15  


<210> 4159
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4159
Thr Ala Leu Asn Asn His Thr Val Gly Arg Tyr
 1               5                  10      


<210> 4160
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4160
Arg Leu Leu Val Pro Gly Thr Tyr Asn Leu Thr Val Val Leu
 1               5                  10                  


<210> 4161
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4161
Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe
 1               5                  10              


<210> 4162
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4162
Arg Gly Ile Gly Asn Trp Ser Asp Ser Lys Ser
 1               5                  10      


<210> 4163
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4163
Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val
 1               5                  10      


<210> 4164
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4164
Phe Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp
 1               5                  10                  


<210> 4165
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4165
Ile Leu Gly Asn Thr Thr Ala Glu Asn Arg Ile
 1               5                  10      


<210> 4166
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4166
Arg Pro Gly Ala Cys Thr Asn Ile Thr Met Gly Val Val Cys Lys Leu
 1               5                  10                  15      


<210> 4167
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4167
Lys Gln Pro Val Ser Pro Val Ile His Pro Pro Val Ser Tyr Asn Asp
 1               5                  10                  15      
Thr Ala Pro Arg Ile
            20      


<210> 4168
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4168
Arg Leu Asn Ser Thr His Cys Gln Asp Ile Asn Glu Cys Ala Met Pro
 1               5                  10                  15      
Gly Val Cys Arg His
            20      


<210> 4169
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4169
Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val
 1               5                  10          


<210> 4170
<211> 31
<212> PRT
<213> Homo sapiens

<400> 4170
Arg Leu Leu Asn Leu Thr Asn Pro Glu Ala Ser Thr Ser Val Leu Met
 1               5                  10                  15      
Ala Val Thr His Thr Leu Thr Gln Tyr Pro Phe Asp Phe Arg Gly
            20                  25                  30      


<210> 4171
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4171
Lys Val Asn Asn Ser Ser Leu Ile Gly Val Gly Tyr Thr Gln Thr Leu
 1               5                  10                  15      
Arg Pro Gly Val Lys Leu
            20          


<210> 4172
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4172
Lys Asn Ile Glu Thr Asn Tyr Thr Arg Ile
 1               5                  10  


<210> 4173
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4173
Lys Ile Asn Asn Ile Thr Val Ser Phe Glu Gly Asn Pro Ser Gly Ser
 1               5                  10                  15      


<210> 4174
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4174
Lys Phe Gln Asn Ile Thr Asp Phe Trp Lys Arg
 1               5                  10      


<210> 4175
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4175
Arg Leu Tyr Pro Asn Glu Phe Val Asn Tyr Ser Asn Ala Val Thr
 1               5                  10                  15  


<210> 4176
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4176
Arg Ala Glu Cys Cys Ala Ser Gly Asn Ile Asp Thr Ala Trp Ser Asn
 1               5                  10                  15      
Leu Thr His Pro Gly Asn Lys Ile
            20                  


<210> 4177
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4177
Leu Val Glu Ala Trp Asp Ser Ser Asn Asp Thr Val Gln Pro Asp Ser
 1               5                  10                  15      
Ile Ile Glu Lys Ala
            20      


<210> 4178
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4178
Lys Asn Tyr Ile Ile Leu Asn Met Thr Glu Asn Ile Asp Cys Glu Val
 1               5                  10                  15      
Phe Arg Gln
            


<210> 4179
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4179
Val Asn Val Ser Asp Ile Asn Asp Asn Pro Pro Glu Phe Arg Gln
 1               5                  10                  15  


<210> 4180
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4180
Arg Gln Thr Leu Phe Phe Asn Gly Thr Arg Ala
 1               5                  10      


<210> 4181
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4181
Arg Asn Thr Thr Trp Gln Ala Gly His Asn
 1               5                  10  


<210> 4182
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4182
Arg Ile Gly Thr Phe Cys Ser Asn Gly Thr Val Ser Arg Ile
 1               5                  10                  


<210> 4183
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4183
Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys Gly
 1               5                  10                  15  


<210> 4184
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4184
Arg Ala Thr Val Pro Val Tyr Ile Asn Thr Thr Asn Ala Asn Lys Tyr
 1               5                  10                  15      


<210> 4185
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4185
Arg Ala Ala Ser Asn Phe Thr Glu Ile Lys Asn
 1               5                  10      


<210> 4186
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4186
Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp Cys
 1               5                  10                  15      
Glu Leu Gly Asn Pro Phe Lys Arg
            20                  


<210> 4187
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4187
Lys Asn Leu Asn Phe Ser Thr Arg Tyr
 1               5                  


<210> 4188
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4188
Lys Glu Asn Gln Asn His Ser Tyr Ser Leu Lys Ser
 1               5                  10          


<210> 4189
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4189
Arg Thr Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr
 1               5                  10              


<210> 4190
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4190
Arg Asn Thr Asn Glu Asn Pro Gln Glu Cys Phe Asn Ala Ser Lys Leu
 1               5                  10                  15      


<210> 4191
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4191
Arg Phe Gly Glu Phe Gly Asn Tyr Ser Leu Leu Val Lys Asn
 1               5                  10                  


<210> 4192
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4192
Lys Met Leu Val Asn Phe Leu Ser Glu Asn Lys Ser
 1               5                  10          


<210> 4193
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4193
Lys Glu Lys Gly Asp Asn Ser Thr Asp Thr Thr Gln Gly Asp Pro Leu
 1               5                  10                  15      
Ser
    


<210> 4194
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4194
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met
 1               5                  10                  15      
Arg His
        


<210> 4195
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4195
Lys Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr
 1               5                  10                  15  


<210> 4196
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4196
Lys Ser Pro Ser Val Asp Lys Tyr Asn Val Ser Gly Thr Asn Gly Thr
 1               5                  10                  15      
Cys
    


<210> 4197
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4197
Arg Asn Ile Ala Ala Phe Gly Gly Asp Pro Asn Asn Ile Thr Leu Phe
 1               5                  10                  15      
Gly Glu Ser Ala Gly Gly Ala
            20              


<210> 4198
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4198
Arg Leu Gly Gln Ala Pro Ala Asn Trp Tyr Asn Asp Thr Tyr Pro Leu
 1               5                  10                  15      
Ser Pro Pro Gln Arg Thr
            20          


<210> 4199
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4199
Lys Gly Thr Glu Val Asn Thr Thr Val Ile Gly Glu Asn Asp Pro Ile
 1               5                  10                  15      
Asp Glu Val Gln Gly Phe Leu Phe Gly Lys Leu
            20                  25          


<210> 4200
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4200
Arg Val Glu Thr Gly Val Leu Lys Pro Gly Met Val Val Thr Phe Ala
 1               5                  10                  15      
Pro Val Asn Val Thr Thr Glu Val Lys Ser
            20                  25      


<210> 4201
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4201
Arg Tyr Ala Ala Val Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Glu
 1               5                  10                  15      
Val Pro Thr Leu Arg Leu
            20          


<210> 4202
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4202
Lys Asn Phe Ser Ile Ile Leu Leu Val Thr Val Leu His Cys His Leu
 1               5                  10                  15      
Thr
    


<210> 4203
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4203
Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly
 1               5                  10                  15  


<210> 4204
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4204
Arg Ala Asp Met Thr Lys Asn Arg Thr Val
 1               5                  10  


<210> 4205
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4205
Lys Val Asn Asn Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu
 1               5                  10                  15      
Lys Pro Gly Ile Lys Leu
            20          


<210> 4206
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4206
Lys Thr Ala Val Pro Pro Leu Ser Glu Gly Asp Gly Tyr Ser Ser Glu
 1               5                  10                  15      
Asn Thr Ser Arg Ala His Thr Pro Leu Asn Thr Pro Asp Pro
            20                  25                  30  


<210> 4207
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4207
Lys Gly Ile Glu Tyr Ala Asp Ser Phe Thr Phe Asn Pro Ser Lys Trp
 1               5                  10                  15      


<210> 4208
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4208
Lys Glu Arg Leu Gly Gly Gly Leu Gly Val Ala Gly Gly Asn Ser Thr
 1               5                  10                  15      
Arg Glu Arg Leu
            20  


<210> 4209
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4209
Ala Leu Val Asn Thr Ser Asn Leu Ile Gly Tyr Gln Thr Asn His Ile
 1               5                  10                  15      
Arg Glu
        


<210> 4210
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4210
Arg Thr Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu
 1               5                  10                  15      


<210> 4211
<211> 40
<212> PRT
<213> Homo sapiens

<400> 4211
Arg Gly Ser Asp Gly Ser Val Gly Pro Val Gly Pro Ala Gly Pro Asn
 1               5                  10                  15      
Gly Ser Ala Gly Pro Pro Gly Phe Pro Gly Ala Pro Gly Pro Lys Gly
            20                  25                  30          
Glu Ile Gly Ala Val Gly Asn Ala
        35                  40  


<210> 4212
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4212
Arg Ala Ala Pro Cys Pro Val Pro Ser Ser Pro Gly Gln Glu Leu Cys
 1               5                  10                  15      
Gly Asn Asn Asn Val Thr Tyr Ile Ser
            20                  25  


<210> 4213
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4213
Lys Glu Lys Asp Leu Asn Glu Thr Leu Leu Arg Ser
 1               5                  10          


<210> 4214
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4214
Lys Asp Leu Gly Gln Gly Gln Gly Gln Val Gln Val Gln Asn Gly Thr
 1               5                  10                  15      
Leu Arg Ile
            


<210> 4215
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4215
His Leu Glu Cys Ser Cys His Asn Asn Ser Thr Cys Glu Pro Ala Thr
 1               5                  10                  15      
Gly Thr Cys Arg Cys
            20      


<210> 4216
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4216
Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met
 1               5                  10              


<210> 4217
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4217
Thr Ala Asn Phe Ser Thr Phe Tyr Gly Met Leu Leu Gly Tyr Ala Asn
 1               5                  10                  15      
Ala Thr Gln Arg Gly
            20      


<210> 4218
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4218
Arg Trp Trp His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp
 1               5                  10                  15      


<210> 4219
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4219
Arg Gln Thr Pro Glu Tyr Gln Asn Glu Ser Ser Arg Asn
 1               5                  10              


<210> 4220
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4220
Arg Ile Thr Cys Val Gly Asn Asp Ser Phe Ile Gly Leu Ser
 1               5                  10                  


<210> 4221
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4221
Arg Phe Glu Ala Glu His Ile Ser Asn Tyr Thr Ala Leu Leu Leu Ser
 1               5                  10                  15      
Arg Asp
        


<210> 4222
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4222
Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn Ala Thr Tyr Ala Ser
 1               5                  10                  15      


<210> 4223
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4223
Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val
 1               5                  10                  15      


<210> 4224
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4224
Arg Ser Leu Cys Asn Ser Ile Ile Ser Leu Asn Thr Thr Ile Ser Cys
 1               5                  10                  15      
Ser Glu Ala Gln Lys Ile
            20          


<210> 4225
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4225
Arg Asn Gly Thr Gln Leu Gln Asn Phe Thr Leu Asp Arg Ser
 1               5                  10                  


<210> 4226
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4226
Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala
 1               5                  10                  15      
Thr Val Trp Lys Leu
            20      


<210> 4227
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4227
Arg Glu Thr Ala Ser Asn Cys Asn Gly Ser Leu Ala His Pro Ser Asp
 1               5                  10                  15      


<210> 4228
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4228
Arg Glu Leu Leu Leu Asp Phe Ala Asn Ser Ser Ala Glu Leu Thr Gly
 1               5                  10                  15      


<210> 4229
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4229
Lys Asn Thr Ser Leu Val Thr Ile Phe Met Ile Trp Asn
 1               5                  10              


<210> 4230
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4230
Lys Asn Ser Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu
 1               5                  10                  


<210> 4231
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4231
Ile Phe Asn Ala Ala Gln Leu Asp Asn Tyr Thr Arg Ile
 1               5                  10              


<210> 4232
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4232
Phe Thr Ile Asn Phe Thr Ile Thr Asn Leu Arg Tyr
 1               5                  10          


<210> 4233
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4233
Ala Cys Lys Asn Val Thr Leu His Val Pro Ser Lys Leu
 1               5                  10              


<210> 4234
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4234
Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser
 1               5                  10                  


<210> 4235
<211> 35
<212> PRT
<213> Homo sapiens

<400> 4235
Lys Leu Leu Gly Gly Gly Asp Glu Glu Ala Ile Arg Pro Gln Met Gln
 1               5                  10                  15      
Gln Ile Leu Asp Phe Glu Thr Ala Leu Ala Asn Ile Thr Ile Pro Gln
            20                  25                  30          
Glu Lys Arg
        35  


<210> 4236
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4236
Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met
 1               5                  10          


<210> 4237
<211> 31
<212> PRT
<213> Homo sapiens

<400> 4237
Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu Ala
 1               5                  10                  15      
Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala
            20                  25                  30      


<210> 4238
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4238
Arg Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln
 1               5                  10                  15      
Ile Glu Ala Leu Leu Met Arg Ala
            20                  


<210> 4239
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4239
Arg Phe Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro
 1               5                  10                  15      
Gly Val Pro Gly Arg Glu
            20          


<210> 4240
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4240
Arg Glu Gln Arg Pro Gly Gln Asn Cys Ser Asn Tyr Thr Val Arg Phe
 1               5                  10                  15      


<210> 4241
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4241
Pro Asn Ser Asn Thr Asn Ser Ser Val Gln His Val Gln Ile Arg Val
 1               5                  10                  15      
Ala Arg Leu
            


<210> 4242
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4242
Lys Asn Phe Ser Ser Glu Ile Glu Asp Leu Glu Lys Glu
 1               5                  10              


<210> 4243
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4243
Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe Arg Val
 1               5                  10          


<210> 4244
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4244
Arg Glu Gly Ser Leu Pro Gly Asn Ser Thr Ile Ser Ile Arg Ala
 1               5                  10                  15  


<210> 4245
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4245
Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys
 1               5                  10                  15      
Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly
            20                  25          


<210> 4246
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4246
Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe
 1               5                  10                  15      
Gln Asn His Leu Gly Ser Cys Gln Lys Cys
            20                  25      


<210> 4247
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4247
Lys Leu Asn Gln Thr Glu Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn
 1               5                  10                  15      
Thr Arg Ile
            


<210> 4248
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4248
Lys Gly Gln Gly Asn Lys Val Gln Asn Gly Ser Val His Gln Lys Asp
 1               5                  10                  15      


<210> 4249
<211> 34
<212> PRT
<213> Homo sapiens

<400> 4249
Arg Cys Val Ser Gly Thr Gln Val His Met Asn Asn Val Thr Val Thr
 1               5                  10                  15      
Leu His Asp Ala Thr Ile Gln Ala Tyr Leu Ser Asn Ser Ser Phe Ser
            20                  25                  30          
Arg Gly
        


<210> 4250
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4250
Arg Leu Glu Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys
 1               5                  10                  15      
Glu
    


<210> 4251
<211> 29
<212> PRT
<213> Homo sapiens

<400> 4251
Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr Phe Gln Asn
 1               5                  10                  15      
Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys
            20                  25                  


<210> 4252
<211> 32
<212> PRT
<213> Homo sapiens

<400> 4252
Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser Ser Ser Val Gln Ser
 1               5                  10                  15      
Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu Ser Tyr Phe Lys Gly
            20                  25                  30          


<210> 4253
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4253
Leu Ala Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp
 1               5                  10                  15      
Arg Glu
        


<210> 4254
<211> 36
<212> PRT
<213> Homo sapiens

<400> 4254
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
 1               5                  10                  15      
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
            20                  25                  30          
Thr Ile Lys Trp
        35      


<210> 4255
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4255
Lys Asp Ser Ile Thr Gly Ser Gly Leu Glu Asn Ala Thr Ile Ser Val
 1               5                  10                  15      
Ala Gly Ile Asn His Asn Ile Thr Thr Gly Arg Phe
            20                  25              


<210> 4256
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4256
Arg Gly Val Asn Gly Leu Ile Asn Gly Lys Ala Asn Ser Asn Lys Ser
 1               5                  10                  15      
Leu Pro Thr
            


<210> 4257
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4257
Gln Ile Glu Gln Leu Asn Arg Thr Lys Lys
 1               5                  10  


<210> 4258
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4258
Lys Met Ile Ser Gly Leu Gln Ala Leu Leu Leu Asn Gly Ser Leu Pro
 1               5                  10                  15      
Glu Asp Glu Gln Glu Arg Pro Leu Ala Leu Cys
            20                  25          


<210> 4259
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4259
Lys Ile Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg
 1               5                  10                  15      


<210> 4260
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4260
Lys His Leu Asn Ser Ser His Pro Arg Ser
 1               5                  10  


<210> 4261
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4261
Lys Ala Val Glu Asn Gly Ser Glu Ala Leu Met Ile Leu Asp
 1               5                  10                  


<210> 4262
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4262
Val Ser Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala
 1               5                  10                  15      
Arg Asn
        


<210> 4263
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4263
Arg Gln Gly Glu His Leu Ser Asn Ser Thr Ser Ala Phe Ser
 1               5                  10                  


<210> 4264
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4264
Arg Lys Phe Thr Asn Ile Ser Asp Leu Gln Pro Lys Pro
 1               5                  10              


<210> 4265
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4265
Leu Ile Gln Leu Asn His Thr Arg Arg
 1               5                  


<210> 4266
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4266
Leu Cys Gln Cys Arg Pro Gly Glu Gly Asn Cys Ser Cys Cys Lys Glu
 1               5                  10                  15      


<210> 4267
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4267
Lys Val Asn Asn Gly Pro Leu Gly Asn Pro Ile Trp Asn Ile Ser Gly
 1               5                  10                  15      
Asp Pro Thr Arg Thr
            20      


<210> 4268
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4268
Lys Pro Cys Asn Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr
 1               5                  10                  15      


<210> 4269
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4269
Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe Ser
 1               5                  10              


<210> 4270
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4270
His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg Thr
 1               5                  10          


<210> 4271
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4271
Tyr Ser Thr Asp Cys Thr Asn Cys Thr Cys Ser Gly Gly Arg Trp
 1               5                  10                  15  


<210> 4272
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4272
Ser Ser Gln Ile Gly Phe Asn Cys Ser Trp Cys Ser Lys Leu
 1               5                  10                  


<210> 4273
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4273
Arg Tyr His Asn Gln Thr Leu Arg Tyr
 1               5                  


<210> 4274
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4274
Arg Val Gly Asn Asp Thr His Cys Gln Pro Thr Lys Ile
 1               5                  10              


<210> 4275
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4275
Arg Ser Leu Thr Leu Glu Pro Asp Pro Ile Val Val Pro Gly Asn Val
 1               5                  10                  15      
Thr Leu Ser Val
            20  


<210> 4276
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4276
Arg Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys Tyr
 1               5                  10              


<210> 4277
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4277
Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr
 1               5                  10                  15  


<210> 4278
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4278
Arg Met Asn Val Thr Trp Arg Leu
 1               5              


<210> 4279
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4279
Arg Leu Asn Asp Thr Val Gly Val Thr Lys Lys
 1               5                  10      


<210> 4280
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4280
Arg His Val Tyr Asn Asn Leu Thr Glu Glu Gln Lys Gly
 1               5                  10              


<210> 4281
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4281
Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn
 1               5                  10                  15      
Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val
            20                  25                  30  


<210> 4282
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4282
Arg Ala Gln Pro Gly Thr Met Ser Asn Gly Thr Glu Thr Arg Gly
 1               5                  10                  15  


<210> 4283
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4283
Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser
 1               5                  10                  15      
Leu Gln
        


<210> 4284
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4284
Gln Ser Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly
 1               5                  10              


<210> 4285
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4285
Leu Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro
 1               5                  10                  15      
Arg Gln
        


<210> 4286
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4286
Lys Val Arg Val Pro Glu Asn Ile Thr Leu Tyr Thr
 1               5                  10          


<210> 4287
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4287
Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Thr Met Glu Asn
 1               5                  10                  15      
Val
    


<210> 4288
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4288
Lys Arg Pro Phe Ile Asn Leu Thr Ala Gly Gln Pro Thr Ser
 1               5                  10                  


<210> 4289
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4289
Lys Met Asn Phe Thr Gly Gly Asp Thr Cys His Lys Val
 1               5                  10              


<210> 4290
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4290
His Val Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met
 1               5                  10          


<210> 4291
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4291
Ala Ala Leu Leu Pro Gln Asn Asp Thr Arg Leu
 1               5                  10      


<210> 4292
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4292
Arg Leu Cys Leu Asn Asn Asp Thr Lys Glu
 1               5                  10  


<210> 4293
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4293
Arg Glu Ala Cys Phe Asp Pro Gly Asn Ile Met Asn Gly Thr Arg Val
 1               5                  10                  15      


<210> 4294
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4294
Arg Asp Thr Phe Phe Asn Leu Ser Leu Lys Glu
 1               5                  10      


<210> 4295
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4295
Pro Ile Pro Ile Ile Val Asn Asn Phe Ser Glu Phe Tyr Lys Glu
 1               5                  10                  15  


<210> 4296
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4296
Lys Ser Thr Gln Gly Phe Leu Asn Gly Ser Glu Val Ser Glu Leu Leu
 1               5                  10                  15      
Arg Asn
        


<210> 4297
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4297
Lys Leu Gln Asn Asn Ser Tyr Leu Trp Gln Ile Pro Leu Thr
 1               5                  10                  


<210> 4298
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4298
Lys His Ile Glu Val Asn Gly Ser Lys Ile
 1               5                  10  


<210> 4299
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4299
Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Thr Glu Lys Ile
 1               5                  10                  


<210> 4300
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4300
Arg Tyr Gly Glu Asn Asn Ser Leu Ser Val Glu Gly Phe Arg Lys
 1               5                  10                  15  


<210> 4301
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4301
Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His Thr Val Ser
 1               5                  10                  15      
Ser Lys Glu
            


<210> 4302
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4302
Lys Ser Thr Gly Gly Ala Pro Thr Phe Asn Val Thr Val Thr Lys Thr
 1               5                  10                  15      


<210> 4303
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4303
Arg Arg Asn Ala Thr Gly Asp Tyr Lys Cys
 1               5                  10  


<210> 4304
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4304
Gly Ser Arg Pro Ala Ala Leu Pro Ser Asn Leu Ser His Leu Leu Asn
 1               5                  10                  15      
His Ser Leu Gln Arg Thr
            20          


<210> 4305
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4305
Lys Leu Val Tyr Ala Asn Glu Cys Ala Asn Phe Thr Thr Asn Val Ser
 1               5                  10                  15      
Ala Arg Phe
            


<210> 4306
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4306
Ser Pro Arg Thr Ala Gln Gly Leu Pro Gly Thr Ser Asn Ser Asn Ser
 1               5                  10                  15      
Ser Arg Ser
            


<210> 4307
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4307
Arg Gly His Ile Asn Asp Ser Gln Ala Ala Pro Ala Pro Leu Leu Pro
 1               5                  10                  15      
Val Tyr
        


<210> 4308
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4308
Leu Ala Pro Asn Pro Thr Asn Ala Thr Thr Lys Ala
 1               5                  10          


<210> 4309
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4309
Lys Cys His Ala Gly Tyr Ile Gly Asp Asn Cys Asn Cys Ser Thr Asp
 1               5                  10                  15      
Ile Ser Thr Cys Arg Gly
            20          


<210> 4310
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4310
Leu Gly Asp Val Tyr Gln Ser Pro Cys Thr Met Ala Gln Arg Pro Gln
 1               5                  10                  15      
Asn Phe Asn Ser Ser Ala Arg Val
            20                  


<210> 4311
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4311
Arg Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr
 1               5                  10                  


<210> 4312
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4312
Arg Leu Met Val Asp Ser Met Gly Asn Thr Ser Leu Val Val Pro Glu
 1               5                  10                  15      
Asn Cys Arg Gly
            20  


<210> 4313
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4313
Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr
 1               5                  10                  15      
Asp Gly Pro Ser Glu Gln Asn
            20              


<210> 4314
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4314
Arg Thr Ala Ser Gly Asn Ile Leu Ala Gln Asn Leu Ala Asn Gln Thr
 1               5                  10                  15      
Val
    


<210> 4315
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4315
Arg Cys Leu Pro Asn Pro Thr Pro Glu Gly Gly Ala Val Pro Gly Pro
 1               5                  10                  15      
Lys Gln
        


<210> 4316
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4316
Asn Gly Met Val Asn Ala Ile Ser Thr Gly Asn Trp Ser Leu Lys Arg
 1               5                  10                  15      
Phe Lys Met
            


<210> 4317
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4317
Lys Thr Asn Ser Ser His Tyr Gly Glu Phe Leu Pro Ile Pro
 1               5                  10                  


<210> 4318
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4318
Lys Arg Asn Val Pro Gln Asn Leu Ser Pro His Ser Gln Arg Pro
 1               5                  10                  15  


<210> 4319
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4319
Lys Asn Gly Thr Ala Asp Gly Pro His Ser Pro Thr
 1               5                  10          


<210> 4320
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4320
Phe Glu Asn Tyr Ser Leu Cys His Arg Cys
 1               5                  10  


<210> 4321
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4321
Arg Leu Phe Asn Leu Thr Ser Thr Phe Ser Arg His
 1               5                  10          


<210> 4322
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4322
Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn
 1               5                  10  


<210> 4323
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4323
Leu Gln Leu Asn Leu Thr Tyr Glu Arg Lys
 1               5                  10  


<210> 4324
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4324
Leu Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser
 1               5                  10                  15  


<210> 4325
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4325
Ile Gln Leu Glu Glu Asn Pro Trp Asn Cys Thr Cys Asp Leu Leu Pro
 1               5                  10                  15      
Leu Lys Ala
            


<210> 4326
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4326
Arg Val Asn Val Leu Ser Asn Asn Ser Leu Tyr Ile Ala Asp Ala Gln
 1               5                  10                  15      
Lys Glu
        


<210> 4327
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4327
Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val Trp Tyr Thr Ser Lys
 1               5                  10                  15      
Pro Lys Glu
            


<210> 4328
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4328
Arg Arg Gly Gln Phe Glu Ser Val Ala Pro Ser Gln Asn Phe Ser Asp
 1               5                  10                  15      
Ser Ser Glu Ser Asp Thr His Pro Phe Val
            20                  25      


<210> 4329
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4329
Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser Asp Gln Arg Gln
 1               5                  10                  15  


<210> 4330
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4330
Arg Leu Ser Asp Thr Ala Asn Tyr Thr Cys Val Ala Lys Asn
 1               5                  10                  


<210> 4331
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4331
Arg Ile Ile Ile Asp Gly Ala Asn Leu Thr Ile Ser Asn
 1               5                  10              


<210> 4332
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4332
Arg His Tyr Glu Asn His Ser Ala Ile Met
 1               5                  10  


<210> 4333
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4333
Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys Ala
 1               5                  10          


<210> 4334
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4334
Lys Val Trp Cys Leu Gly Asn Glu Thr Arg Tyr
 1               5                  10      


<210> 4335
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4335
Lys Val Leu Ala Lys Pro Glu Asn Leu Ser Ala Ser Phe
 1               5                  10              


<210> 4336
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4336
Lys Ser Cys Glu Tyr Asn Gly Thr Thr Tyr Gln
 1               5                  10      


<210> 4337
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4337
His Ser Gly Val Val Gln Val Pro Met Ala Asn Cys Ser Leu Tyr Arg
 1               5                  10                  15      
Ser
    


<210> 4338
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4338
Phe Val Met Asn Phe Ser Asn Gly Glu Ile Ile Asp Ile Phe Lys Pro
 1               5                  10                  15      
Val Arg Lys
            


<210> 4339
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4339
Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys Leu
 1               5                  10      


<210> 4340
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4340
Arg Arg Phe Asn Thr Thr Glu Arg Val
 1               5                  


<210> 4341
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4341
Arg Asn Tyr Glu Ile Ile Gln Gln Pro Met Ser Tyr Asp Asn Leu Thr
 1               5                  10                  15      
Gln Arg Leu
            


<210> 4342
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4342
Arg Gly Leu Glu Leu Thr Asn Thr Ser Ala Tyr Leu Thr
 1               5                  10              


<210> 4343
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4343
Arg Ala Asn Tyr Thr Ile Leu Lys Gly
 1               5                  


<210> 4344
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4344
Leu Leu Met Asn Gln Thr Val Met Ser Lys Asn
 1               5                  10      


<210> 4345
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4345
Leu His Asn Ser Ser Thr Glu Gly Arg Ser
 1               5                  10  


<210> 4346
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4346
Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly Thr Val Leu Leu Arg Trp
 1               5                  10                  15      


<210> 4347
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4347
Lys Tyr Pro Asn Cys Thr Gly Gly Ala Ala Gly Tyr Ile Asp Arg Leu
 1               5                  10                  15      


<210> 4348
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4348
Lys Thr Gln Gly Pro Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser
 1               5                  10                  15      
Val Ala Thr
            


<210> 4349
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4349
Lys Met Val Leu Trp Asn Asp Ser Val Val Arg His
 1               5                  10          


<210> 4350
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4350
Lys Ile Gln Cys Thr Leu Ser Asn Pro Leu Phe Asn Thr Thr Ser Ser
 1               5                  10                  15      
Ile Ile
        


<210> 4351
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4351
Lys Ala Phe Tyr Asn Glu Ser Trp Glu Arg Arg
 1               5                  10      


<210> 4352
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4352
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg Tyr
 1               5                  10          


<210> 4353
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4353
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Ala Met
 1               5                  10                  15      
Arg His
        


<210> 4354
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4354
Met Glu Pro Gln Asn Thr Ser Thr Val Thr Asn Phe Gln
 1               5                  10              


<210> 4355
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4355
Arg Leu Asp Met Ser Gln Asn Val Ser Leu Val Thr Ala Glu Leu Ser
 1               5                  10                  15      
Lys Asp
        


<210> 4356
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4356
Lys Leu His Val Gly Tyr Leu Gln Pro Leu Val Ala Val Gln Val Ser
 1               5                  10                  15      
Phe Ala Pro Asn Asn Thr Gly Lys Glu
            20                  25  


<210> 4357
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4357
Arg Ile Asn Tyr Thr Asp Pro Phe Ser Asn Gln Thr Val Lys Ser
 1               5                  10                  15  


<210> 4358
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4358
Lys Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr
 1               5                  10              


<210> 4359
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4359
Arg Asn Ala Thr Val Val Trp Met Lys Asp
 1               5                  10  


<210> 4360
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4360
Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asn Glu Ser Leu
 1               5                  10                  15      
Arg Ser
        


<210> 4361
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4361
Lys Asp Leu Tyr Glu Tyr Ser Trp Val Gln Gly Pro Leu His Ser Asn
 1               5                  10                  15      
Glu Thr Asp Arg Leu
            20      


<210> 4362
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4362
Lys His His Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu
 1               5                  10                  15      
Gly Leu Glu Asn Arg Glu
            20          


<210> 4363
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4363
Arg Tyr Ser Leu Asn Val Thr Tyr Asn Tyr Pro Val His Tyr Phe Asp
 1               5                  10                  15      
Gly Arg Lys
            


<210> 4364
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4364
Arg Gly Asn Glu Leu Ser Leu Val Leu Leu Asn Ala Ser Thr Gly Glu
 1               5                  10                  15      
Leu Lys Leu
            


<210> 4365
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4365
Arg Asp Pro Asn Ser Gly Phe Val Phe Asn Leu Asn Pro Leu Asn Ser
 1               5                  10                  15      
Ser Gln Gly Tyr Asn Val Ser Gly Ile Gly Lys Ile
            20                  25              


<210> 4366
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4366
Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu
 1               5                  10                  15  


<210> 4367
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4367
Arg Leu Ala Gly Ala Gly Asn Ser Thr Ala Arg Ile
 1               5                  10          


<210> 4368
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4368
Lys Val Asn Asp Ser Val Pro Phe His Leu Gly Trp Asn Ser Thr Glu
 1               5                  10                  15      
Arg Ser
        


<210> 4369
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4369
Phe Thr Phe Asn Phe Thr Ile Thr Asn Leu His Tyr Glu Glu Asn Met
 1               5                  10                  15      
Gln His Pro Gly Ser Arg Lys
            20              


<210> 4370
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4370
Arg Ser Leu Leu Glu Phe Asn Thr Thr Val Ser Cys Asp Gln Gln Gly
 1               5                  10                  15      
Thr Asn His Arg Val
            20      


<210> 4371
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4371
Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr
 1               5                  10      


<210> 4372
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4372
Arg Thr Tyr Leu Val Asn Ser Ser Asp Ser
 1               5                  10  


<210> 4373
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4373
Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Gly Leu Arg Ser
 1               5                  10                  15  


<210> 4374
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4374
Gln Ile Ser Glu His Ala Pro Glu Ala Ser Gln Pro Ala Glu Asn Ile
 1               5                  10                  15      
Ser Lys Asp
            


<210> 4375
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4375
Glu Ala Asn Ser Leu Ala Ser Ser Gly Pro His Asn Leu Thr Tyr Pro
 1               5                  10                  15      
Leu Gly Pro Arg Asn
            20      


<210> 4376
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4376
Arg Leu Thr Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg
 1               5                  10                  15      
Leu
    


<210> 4377
<211> 33
<212> PRT
<213> Homo sapiens

<400> 4377
Arg Phe Ser Ile Pro Pro Ser Ser Gln Glu Val Met Pro Gly Gly Ser
 1               5                  10                  15      
Val Asn Leu Thr Cys Val Ala Val Gly Ala Pro Met Pro Tyr Val Lys
            20                  25                  30          
Trp
    


<210> 4378
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4378
Arg Asp Trp Tyr Glu Gln Val Asn Gly Ser Asp Gly Met Phe Lys Tyr
 1               5                  10                  15      


<210> 4379
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4379
Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His Asn Val Ser
 1               5                  10                  15      
Arg Leu
        


<210> 4380
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4380
Arg Lys Leu Gly Leu Thr Tyr Asn Thr Thr Cys Cys Asn Lys Asp
 1               5                  10                  15  


<210> 4381
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4381
Leu Glu Phe Gln Gly Tyr Asn Leu Ser Ala Asn Lys Gln
 1               5                  10              


<210> 4382
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4382
Arg Arg Asn Gln Ser Leu Val Gln Asp Met Asp Ser Met Val Arg Leu
 1               5                  10                  15      


<210> 4383
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4383
Arg Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu Thr Gly Leu Thr
 1               5                  10                  15      


<210> 4384
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4384
Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys
 1               5                  10              


<210> 4385
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4385
Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn Lys Thr
 1               5                  10                  15      


<210> 4386
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4386
Phe Leu Leu Glu Asn Val Pro Cys Asn Asn Ala Ser Cys Glu Glu Ala
 1               5                  10                  15      
Arg Arg
        


<210> 4387
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4387
Arg Ile Leu Ala Ile Asn Ser Ser Ser Leu Lys Gly Lys Pro Leu Ser
 1               5                  10                  15      
Glu Ala Ile His Leu Leu
            20          


<210> 4388
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4388
Met Glu Glu Asn Glu Glu Ile Ser Ser Asp Glu Glu Glu Thr Asn Val
 1               5                  10                  15      
Thr Ala Gln Ala Met Gln Ser Asn Asn Gly Arg Gly
            20                  25              


<210> 4389
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4389
Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr Gln Gly Arg Leu Cys Asn
 1               5                  10                  15      
Lys Thr
        


<210> 4390
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4390
Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu
 1               5                  10      


<210> 4391
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4391
Lys Leu Val Ala Leu Ala Val Ile Asp Glu Lys Asn Thr Ser Val Glu
 1               5                  10                  15      
His Thr Arg Leu
            20  


<210> 4392
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4392
Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr Gln Gly Arg Leu
 1               5                  10                  


<210> 4393
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4393
Arg Gly His Glu Val Glu Asp Val Asp Leu Glu Leu Phe Asn Thr Ser
 1               5                  10                  15      
Val Gln Leu
            


<210> 4394
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4394
Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr Met Phe
 1               5                  10                  15      
Asn Lys Asp
            


<210> 4395
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4395
Thr Asn Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys
 1               5                  10                  15      
Ile
    


<210> 4396
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4396
Arg Val Glu Ile Leu Ala Asn Asp Gln Gly Asn Arg Thr
 1               5                  10              


<210> 4397
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4397
Arg Gln Pro Leu Met Asn Gln Ile Ser Asn Val Ser Asn Val
 1               5                  10                  


<210> 4398
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4398
Arg Met Glu Gln Met Ser Asn Met Thr Leu Met Lys Glu
 1               5                  10              


<210> 4399
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4399
Arg Lys Arg Val Leu Asn Val Thr Asn Leu Glu Phe Ser Asp Thr Arg
 1               5                  10                  15      
Met
    


<210> 4400
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4400
Arg Ile Met Gly Pro Asn Tyr Thr Pro Gly Lys Lys
 1               5                  10          


<210> 4401
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4401
Arg His Phe Asn Thr Ser Leu Val Phe Pro Arg Glu
 1               5                  10          


<210> 4402
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4402
Arg Gly Ala Asp Leu Met Asn Lys Ser
 1               5                  


<210> 4403
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4403
Arg Glu Asn Ser Thr Ser Ser Gly Pro Ser
 1               5                  10  


<210> 4404
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4404
Arg Ala Thr Asn Asn Ser Ser Pro Asp Ser
 1               5                  10  


<210> 4405
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4405
Gln Val Pro Pro Ser Leu Pro Arg Asn Ser Thr Met Met Gln Ala Val
 1               5                  10                  15      
Lys Thr
        


<210> 4406
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4406
Pro Pro Tyr Gly Pro Glu Asn Cys Ser Ser Ser Asn Glu Ile Ile Leu
 1               5                  10                  15      
Ser Arg Val
            


<210> 4407
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4407
Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Val Gln Leu Asn Ile Cys
 1               5                  10                  15      
Gln Lys Gly
            


<210> 4408
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4408
Met Arg Gly Asp Met Val Thr Glu Asp Ala Asp Pro Tyr Val Gln Pro
 1               5                  10                  15      
Glu Asp Glu Asn Tyr Glu Asn Asp Ser Val Arg Gln
            20                  25              


<210> 4409
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4409
Met Leu Val Asn Glu Leu Asn His Ser Lys Glu Lys Glu
 1               5                  10              


<210> 4410
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4410
Leu Tyr Met Glu Asn Asp Leu Ser Glu Gly Val Asn Pro Ser Val Gly
 1               5                  10                  15      
Arg Ser
        


<210> 4411
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4411
Leu Met Ser Cys Gly Glu Asn Ile Thr Arg Asn Lys Gly
 1               5                  10              


<210> 4412
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4412
Leu Ile Lys Tyr Asn Thr Cys Val Asn Ala Thr Asp Lys Trp
 1               5                  10                  


<210> 4413
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4413
Leu Ala Gly Thr Asn Ser Ser Ser Leu Lys Ala
 1               5                  10      


<210> 4414
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4414
Lys Asn Val Thr Gly Gln Ala Thr Leu Phe Gln Ala Ser Ser Met Lys
 1               5                  10                  15      
Ser
    


<210> 4415
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4415
Lys Asn Thr Ser Val Pro Val Ser Ala Val Phe Met Asp Lys Pro
 1               5                  10                  15  


<210> 4416
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4416
Lys Asn Ser Thr Gly Ser Ser Lys Leu Thr Pro
 1               5                  10      


<210> 4417
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4417
Lys Asn Ser Ser Thr Met Leu Tyr Ser Arg Gln
 1               5                  10      


<210> 4418
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4418
Lys Asn Leu Thr Thr Ile Leu Asn Glu Tyr Val Ala Met Lys Thr
 1               5                  10                  15  


<210> 4419
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4419
Lys Asn Leu Thr Phe Asp Gln Leu Ala Leu Asp Ser Pro Lys Val
 1               5                  10                  15  


<210> 4420
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4420
Gly Tyr Ala Glu Phe Pro Pro Ser Pro Ser Asn Pro Thr Lys Glu
 1               5                  10                  15  


<210> 4421
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4421
Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn Asn
 1               5                  10                  15      
Pro Ser Arg Met
            20  


<210> 4422
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4422
Ala Ser Tyr Phe Asn Asn Thr Lys Cys
 1               5                  


<210> 4423
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4423
Ala Glu Ala Ser Val His Leu Ser Ala Leu Glu Val Phe Asn Leu Ser
 1               5                  10                  15      
Trp Asn Lys Cys
            20  


<210> 4424
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4424
Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser
 1               5                  10  


<210> 4425
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4425
Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly Gln Ala Asn Tyr Ser
 1               5                  10                  15      
Ala Ala Lys Leu
            20  


<210> 4426
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4426
Arg Tyr Leu Thr Leu Asn Ala Ser Gln Ile Thr Asn Leu Arg Ser
 1               5                  10                  15  


<210> 4427
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4427
Arg Tyr Leu Asn Ser Leu Phe Pro Ser Glu Asn Ser Thr Ala Phe Tyr
 1               5                  10                  15      
Gly
    


<210> 4428
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4428
Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser
 1               5                  10      


<210> 4429
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4429
Arg Val Tyr Cys Asn Leu Ser Ala Ala His Thr
 1               5                  10      


<210> 4430
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4430
Arg Asn Tyr Ser Asp Thr Pro Pro Thr Ser Lys Ser
 1               5                  10          


<210> 4431
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4431
Arg Leu Leu Asn Ile Asn Pro Asn Lys Thr Ser
 1               5                  10      


<210> 4432
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4432
Arg Lys Val Asn Ala Ser Val Pro Arg Gly
 1               5                  10  


<210> 4433
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4433
Arg His Leu Asp Ala Thr Asn Ser Thr Ala Gly Tyr Ser
 1               5                  10              


<210> 4434
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4434
Arg Glu Gln Ile Asn Ile Thr Leu Asp His Arg Cys
 1               5                  10          


<210> 4435
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4435
Arg Glu Asp Asn Pro Asp Lys Asn Pro Glu Ala Pro Leu Asn Val Ser
 1               5                  10                  15      
Arg Val
        


<210> 4436
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4436
Gln Gln Ala Arg Gly Arg Val Ile Asn Ile Thr Ser Val Leu Gly Arg
 1               5                  10                  15      
Leu
    


<210> 4437
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4437
Gln Ala Thr Asp Gly His Asp Arg Pro Leu Thr Asn Cys Ser Ile Ile
 1               5                  10                  15      
Asn Ser Gly Lys Ile
            20      


<210> 4438
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4438
Leu Ser Gly Asp Leu Glu Asp Leu Glu Leu Ala Leu Asn Lys Thr
 1               5                  10                  15  


<210> 4439
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4439
Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp Val Tyr Ser Ser Pro
 1               5                  10                  15      
Gly Arg His
            


<210> 4440
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4440
Lys Tyr Phe Phe Asn Leu Ser Ser Met Thr Cys Glu Lys Phe
 1               5                  10                  


<210> 4441
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4441
Lys Val Val Val Leu Pro Thr Asn Asn Ser Val Ser Gly Glu Leu Ile
 1               5                  10                  15      
Leu
    


<210> 4442
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4442
Lys Ser Ser Gly Leu Trp Asn Asn Thr Val Phe Ile
 1               5                  10          


<210> 4443
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4443
Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly
 1               5                  10                  15      
Lys Cys
        


<210> 4444
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4444
Lys Gly Ala Asn Val Ser Trp Glu Pro Gly Phe Asp Gly Gly Tyr Leu
 1               5                  10                  15      
Gln Arg Phe
            


<210> 4445
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4445
Lys Glu Leu Ile Met Ile Ala Gly Gly Asn Gln Ser
 1               5                  10          


<210> 4446
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4446
Lys Ala Gly His Phe Gln Asn Thr Ser Ser Pro Ser Ala Arg Cys
 1               5                  10                  15  


<210> 4447
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4447
Ala Met Val Val Pro Asn Ala Thr Leu Leu Glu Lys Leu
 1               5                  10              


<210> 4448
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4448
Tyr Asn Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr
 1               5                  10                  15      


<210> 4449
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4449
Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly
 1               5                  10                  15      


<210> 4450
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4450
Lys Phe Phe Val Val Asn Thr Asp Ser Leu Ser Ser Val Thr Asn Ala
 1               5                  10                  15      
Thr Ser
        


<210> 4451
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4451
Val Ile Phe Ser Asp Trp Tyr Asn Thr Ser Val Met Arg Lys
 1               5                  10                  


<210> 4452
<211> 32
<212> PRT
<213> Homo sapiens

<400> 4452
Ser Gly Ser Leu Asn Trp Thr Met Gly Leu Pro Thr Asp Asn Gly His
 1               5                  10                  15      
Asp Ser Asp Gln Val Phe Glu Phe Asn Gly Thr Gln Ala Val Arg Ile
            20                  25                  30          


<210> 4453
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4453
Arg Val Leu Leu Gln Asn Leu Thr Met Ser Tyr Ser Gly Leu Tyr Gln
 1               5                  10                  15      
Cys Thr Ala Gly Asn Glu Ala Gly Lys Glu
            20                  25      


<210> 4454
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4454
Arg Thr Cys Ser Asp Ala Ala Tyr Asn His Thr Thr Phe Pro Asn Leu
 1               5                  10                  15      


<210> 4455
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4455
Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly
 1               5                  10              


<210> 4456
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4456
Arg Leu Glu Val Asp Ala Gln Ser Asn His Thr Val Gly Pro Leu Leu
 1               5                  10                  15      


<210> 4457
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4457
Arg Lys Ile Asn Ser Ser Leu Gln Leu Pro Asp Arg Val
 1               5                  10              


<210> 4458
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4458
Arg Ile His Val Glu Asn Gln Thr Arg Ala
 1               5                  10  


<210> 4459
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4459
Arg Gly Glu Asp Gly Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly
 1               5                  10                  15      
Phe Pro Gly Tyr Pro Gly Asn Arg Gly
            20                  25  


<210> 4460
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4460
Arg Phe Thr Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr Ser Lys
 1               5                  10                  15      
Tyr
    


<210> 4461
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4461
Arg Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp
 1               5                  10                  15      
Phe Asn Lys Phe
            20  


<210> 4462
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4462
Met Asp Val Asp Glu Cys Glu Arg His Pro Cys Gly Asn Gly Thr Cys
 1               5                  10                  15      
Lys Asn
        


<210> 4463
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4463
Lys Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys
 1               5                  10              


<210> 4464
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4464
Lys Trp Gly His Asn Ile Thr Glu Phe Gln Gln Arg Phe
 1               5                  10              


<210> 4465
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4465
Lys Val Leu Gln Cys Leu Asn Ile Ser Val Leu Ser
 1               5                  10          


<210> 4466
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4466
Lys Val Cys Asp Gly Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn
 1               5                  10                  15      
Asn Thr Ser Thr Gly Lys Tyr
            20              


<210> 4467
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4467
Lys Thr Phe Asn Leu Asn Thr Thr Glu Val Glu Pro Cys Arg Arg
 1               5                  10                  15  


<210> 4468
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4468
Lys Ser Ser Glu Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp
 1               5                  10                  15      


<210> 4469
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4469
Lys Ser Glu Gly Ala Ile Gln Val Asn Phe Thr Leu Val Arg Ser
 1               5                  10                  15  


<210> 4470
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4470
Lys Leu Gly Ala Ile Asn Ser Thr Leu Ser Asn Gln Ser Lys Glu
 1               5                  10                  15  


<210> 4471
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4471
Lys Leu Asp Arg Glu Asn Ser Thr Glu Arg Val
 1               5                  10      


<210> 4472
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4472
Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu Met
 1               5                  10          


<210> 4473
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4473
Lys Gly Thr Asn Phe Thr His Leu Val Ala Asp Arg Val
 1               5                  10              


<210> 4474
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4474
Lys Gly Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu
 1               5                  10                  15      
Ile Ser
        


<210> 4475
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4475
Lys Gly Asp Lys Gly Pro Pro Gly Pro Val Gly Ala Asn Gly Ser Pro
 1               5                  10                  15      
Gly Glu Arg Gly
            20  


<210> 4476
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4476
Lys Phe Leu Ser Tyr Asn Val Thr Arg Arg
 1               5                  10  


<210> 4477
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4477
Lys Asp Leu Ser Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu
 1               5                  10                  15      
His Gly
        


<210> 4478
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4478
Lys Asp Leu Gln Asn Val Asn Leu Thr Leu Arg Ile
 1               5                  10          


<210> 4479
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4479
Lys Asp Lys Leu Phe Thr Ala Ile Gly Tyr Ser Glu Ser Thr His Asn
 1               5                  10                  15      
Leu Thr Leu Pro Lys Gln
            20          


<210> 4480
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4480
Lys Cys Leu Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg
 1               5                  10                  15      
Leu
    


<210> 4481
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4481
Lys Cys Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp
 1               5                  10                  15      
Phe Ser
        


<210> 4482
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4482
Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser Cys Gln Ser
 1               5                  10                  15  


<210> 4483
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4483
His Ile Tyr Asn Gln Asn Val Ser Gln Lys Asp
 1               5                  10      


<210> 4484
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4484
Phe Val Ile Gly Gly Asn Phe Thr Gly Ser Gln Arg Ala
 1               5                  10              


<210> 4485
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4485
Tyr Gly Arg Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser
 1               5                  10                  15      


<210> 4486
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4486
Val Arg Glu Glu Thr Val Asn Leu Thr Thr Asp Ser Arg Thr
 1               5                  10                  


<210> 4487
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4487
Val Met Gln Ala Leu Asn Met Ser Ala Ala Leu Thr Ala Arg Lys
 1               5                  10                  15  


<210> 4488
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4488
Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr Leu
 1               5                  10                  15      
Lys Ser
        


<210> 4489
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4489
Thr Leu Gln Pro Asn Gln Asn Met Thr Ser Glu Glu Arg Gln
 1               5                  10                  


<210> 4490
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4490
Arg Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro
 1               5                  10                  15      
Ala Leu
        


<210> 4491
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4491
Arg Val Asp Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp
 1               5                  10                  15      
Pro Ala Cys
            


<210> 4492
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4492
Arg Thr Phe Leu Asn Thr Thr Val Glu Lys His
 1               5                  10      


<210> 4493
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4493
Arg Ser Phe Asp Cys Cys Gly Leu Phe Asn Leu Thr Thr
 1               5                  10              


<210> 4494
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4494
Arg Ser Ala Met Tyr His Ser Asn Met Thr
 1               5                  10  


<210> 4495
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4495
Arg Leu Ala Asn Asp Thr Leu Ile Tyr Phe Thr
 1               5                  10      


<210> 4496
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4496
Arg Ile Phe Thr Phe Met Asn Asp Ser Ser Asn Val Ala Met Leu Gln
 1               5                  10                  15      
Arg Leu
        


<210> 4497
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4497
Arg Gly Asn Ala Ser Gly Leu Gly Ala Gly Pro Arg Pro
 1               5                  10              


<210> 4498
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4498
Arg Asp Ser Leu Phe Ile Asn Gly Tyr Ala Pro Gln Asn Leu Ser Ile
 1               5                  10                  15      
Arg Gly
        


<210> 4499
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4499
Pro Leu Val Asn His Ser Ser Gly Met Leu Val Lys Cys
 1               5                  10              


<210> 4500
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4500
Asn Cys Leu Gly Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn
 1               5                  10                  15  


<210> 4501
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4501
Met Ala Gly Val Ala Ala Pro Pro Gly Asn Gly Thr Arg Gly
 1               5                  10                  


<210> 4502
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4502
Leu Ser Asn Leu Glu Glu Thr Leu Asn Leu Ser Lys Tyr
 1               5                  10              


<210> 4503
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4503
Leu Gly Ile Thr Glu Ser Ser Asn Met Thr Ile Ile Thr Arg Thr
 1               5                  10                  15  


<210> 4504
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4504
Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr Val
 1               5                  10                  15      
Lys Ala
        


<210> 4505
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4505
Leu Asp Gly Asn Gly Thr Thr Phe Asn Arg Thr
 1               5                  10      


<210> 4506
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4506
Lys Thr Thr Asn Ser Ser Ala Ala Asp Pro Arg Glu
 1               5                  10          


<210> 4507
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4507
Lys Thr Leu Ser Asn Ser Ser Gln Ser Glu Leu Glu Asn Arg Leu
 1               5                  10                  15  


<210> 4508
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4508
Lys Met Cys Pro Gln Asn Thr Ser Ile Pro Ile Arg Gly
 1               5                  10              


<210> 4509
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4509
Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val Lys Arg
 1               5                  10                  15      


<210> 4510
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4510
Lys Leu Phe Asn Thr Ser Val Glu Val Leu Pro Phe Asp
 1               5                  10              


<210> 4511
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4511
Lys Leu Phe Ile Tyr Asn Pro Thr Thr Gly Glu Phe Leu Gly Arg Thr
 1               5                  10                  15      


<210> 4512
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4512
Lys His Leu Asn Ala Ser Asn Pro Thr Glu Pro Ala Thr Ile Ile Phe
 1               5                  10                  15      
Thr Ala Ala Arg Glu
            20      


<210> 4513
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4513
Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe His Pro Leu
 1               5                  10                  15      
Ile
    


<210> 4514
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4514
Lys Ala Asn Asn Ser Trp Phe Gln Ser Ile Leu Arg Gln
 1               5                  10              


<210> 4515
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4515
Lys Ala Ala Glu Asn Phe Thr Leu Leu Val Lys Asn
 1               5                  10          


<210> 4516
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4516
Ile Asn Tyr Pro Gln Thr Tyr Pro Asn Ser Thr Val Cys Glu Trp Glu
 1               5                  10                  15      
Ile Arg Val
            


<210> 4517
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4517
Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr
 1               5                  10      


<210> 4518
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4518
Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr
 1               5                  10                  


<210> 4519
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4519
Asp Ser Ser Asn Glu Leu Ile Ser Asp Gln Asn His Ser Tyr Pro Arg
 1               5                  10                  15      
Lys
    


<210> 4520
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4520
Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu Glu Gly Lys
 1               5                  10                  15      
Ile
    


<210> 4521
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4521
Ala Ala His Asn Ala Ser Val Asp Met Cys Glu Leu Lys Arg Asp
 1               5                  10                  15  


<210> 4522
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4522
Met Asp Gly Val Asn Asp Ser Ser Leu Gln Gly Phe Val Leu Met Ser
 1               5                  10                  15      


<210> 4523
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4523
Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr
 1               5                  10                  15      
Ser Asp Asn Ser Met His Val Lys Cys
            20                  25  


<210> 4524
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4524
Arg Thr Pro Ala Ser Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val
 1               5                  10                  15      
Phe Tyr Thr Lys Glu
            20      


<210> 4525
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4525
Arg Tyr Lys Pro Asp Thr Leu Ala Val Ala Val Glu Asn Gly Thr Gly
 1               5                  10                  15      
Thr Asp Arg Gln
            20  


<210> 4526
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4526
Lys Asp Asn Ile Thr Ala His Asn Ile Ser Trp Arg Asn
 1               5                  10              


<210> 4527
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4527
Lys Tyr Asp Arg Glu Pro Ala Glu Phe Asn Leu Thr Lys Lys
 1               5                  10                  


<210> 4528
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4528
Lys Asp Gly His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys
 1               5                  10                  15      
Lys
    


<210> 4529
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4529
Arg Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu Ser Asn Leu Lys
 1               5                  10                  15      
Met
    


<210> 4530
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4530
Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr Ser Lys Leu
 1               5                  10                  


<210> 4531
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4531
Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His Asn Ser Arg Lys
 1               5                  10                  15      


<210> 4532
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4532
Arg Ser Asn Ser Ser Gly Ala Asp Gly Gly Asp Thr Pro Pro Leu Pro
 1               5                  10                  15      
Ser Pro Pro Asp Lys Gly
            20          


<210> 4533
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4533
Arg Ile Gly Pro Gly Glu Pro Leu Glu Leu Leu Cys Asn Val Ser Gly
 1               5                  10                  15      
Ala Leu Pro Pro Ala Gly Arg His
            20                  


<210> 4534
<211> 31
<212> PRT
<213> Homo sapiens

<400> 4534
Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser
 1               5                  10                  15      
Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly
            20                  25                  30      


<210> 4535
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4535
Arg Ala Asn His Ser Gly Ala Val Val Leu Leu Lys Arg
 1               5                  10              


<210> 4536
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4536
Arg Asp Tyr Tyr Leu Asn Lys Thr
 1               5              


<210> 4537
<211> 32
<212> PRT
<213> Homo sapiens

<400> 4537
Lys Ser Ile Asn Gly Leu Ile Asn Lys Val Asn Ile Ser Asn Ile Ser
 1               5                  10                  15      
Ile Ile Ile Gln Glu Leu Leu Gln Glu Asn Ile Val Arg Gly Arg Gly
            20                  25                  30          


<210> 4538
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4538
Lys Val Val Asn Ser Thr Thr Gly Thr Gly Glu His Leu Arg Asn
 1               5                  10                  15  


<210> 4539
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4539
Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr Lys Asp
 1               5                  10                  


<210> 4540
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4540
Lys His Asn Leu Met Thr Val Glu Gln Asn Asn Gly Ser Ser Gln Lys
 1               5                  10                  15      
Lys
    


<210> 4541
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4541
Arg Ser Asn Phe Ser Cys Ala Ser Thr Ser Gly Val Ser Gly Ala Ser
 1               5                  10                  15      
Ala Ser Ala Ser
            20  


<210> 4542
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4542
Arg Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Asn Gly Ser Ser Gly
 1               5                  10                  15      
Lys Lys Ser
            


<210> 4543
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4543
Lys Leu Ile Met Asn Gln Thr Ser Gln Lys Lys Asp
 1               5                  10          


<210> 4544
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4544
Arg Ile Leu Asn Trp Ser Ser Trp Ser Glu Ala Ile
 1               5                  10          


<210> 4545
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4545
Arg Val Ser Lys Asp Gly Asn Gly Ala Leu Pro Leu Asn Leu Thr Cys
 1               5                  10                  15      
Thr Val Ser
            


<210> 4546
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4546
Met Glu Asn Ser Ser Ala Trp Val Val Glu Ile Gln Met Leu Lys Cys
 1               5                  10                  15      


<210> 4547
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4547
Ala Ile Val Asp Met Val Asn Asn Ser Thr Ile His Arg Gly
 1               5                  10                  


<210> 4548
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4548
Lys Gly Asn Glu Thr Ile Val Asn Leu Ile His Ser Thr Arg Ile
 1               5                  10                  15  


<210> 4549
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4549
Arg His Leu Asn Ser Thr Asp Asp Ala Asp Arg Ile Pro Phe Gln Glu
 1               5                  10                  15      
Asp Trp Met Lys Met
            20      


<210> 4550
<211> 40
<212> PRT
<213> Homo sapiens

<400> 4550
Lys Ala Gly Tyr Phe Asn Phe Thr Ser Ala Thr Ile Thr Tyr Leu Ala
 1               5                  10                  15      
Gln Glu Asp Gly Pro Val Val Ile Gly Ser Thr Ser Ala Pro Gly Gln
            20                  25                  30          
Gly Gly Ile Leu Ala Gln Arg Glu
        35                  40  


<210> 4551
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4551
Arg Tyr Asn Leu Thr Ser Gln Asp
 1               5              


<210> 4552
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4552
Arg Lys Arg Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser
 1               5                  10                  15      
Asn Asn Ser Gln Ala Cys Ala Gln
            20                  


<210> 4553
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4553
Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys Val
 1               5                  10          


<210> 4554
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4554
Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His
 1               5                  10                  


<210> 4555
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4555
Lys Ser Tyr Ala Gly Phe Leu Thr Val Asn Lys Thr
 1               5                  10          


<210> 4556
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4556
Ile Asn Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro
 1               5                  10                  15      
Ser Asn Thr Ser His Lys Leu
            20              


<210> 4557
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4557
Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile Ser Val Arg Gly
 1               5                  10                  15  


<210> 4558
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4558
Arg Phe Phe Asn Phe Ser Trp Arg Val
 1               5                  


<210> 4559
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4559
Leu Ser Ile Ile Gly Tyr Asn Thr Thr Ser Thr Val Pro Lys Glu
 1               5                  10                  15  


<210> 4560
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4560
Arg Gly Met Gly Pro Cys Asn Leu Ser Ser Ala Ala Gly Pro Thr Ala
 1               5                  10                  15      
Glu Lys Ser
            


<210> 4561
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4561
Lys Ile Trp Asn Ser Ser Leu Gln Thr Asn Lys Glu Pro Val Gly Ile
 1               5                  10                  15      
Leu
    


<210> 4562
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4562
Ile Thr Leu Asn Ser Glu Glu Asp Tyr Pro Asn Gly Thr Trp Leu Gly
 1               5                  10                  15      
Asp Glu Asn Asn Pro Glu Met Arg Val Arg Cys
            20                  25          


<210> 4563
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4563
Glu Asn Ser Ser Ser Thr Asn Leu Cys Val Glu Asp Leu Gln Lys Asn
 1               5                  10                  15      
Lys Asp
        


<210> 4564
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4564
Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr Gln Gly Val Pro Lys
 1               5                  10                  15      
Asp
    


<210> 4565
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4565
Arg Thr Ile Phe Asn Cys Thr Leu Phe Asp Met Gly
 1               5                  10          


<210> 4566
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4566
Arg Gly Tyr Asn Val Thr Tyr Trp Arg Glu
 1               5                  10  


<210> 4567
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4567
Ala Ser Asn Ile Tyr Gly Thr Val Asn Asn Thr Val Thr Leu Arg Val
 1               5                  10                  15      


<210> 4568
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4568
Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro Pro Arg
 1               5                  10                  15      
Asn
    


<210> 4569
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4569
Arg Gly Gly Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn
 1               5                  10                  15      
Phe Ser Gly Arg Gly Gly Phe Gly Gly Ser Arg Gly
            20                  25              


<210> 4570
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4570
Lys Trp Thr Pro Asn Gln Leu Met Asn Gly Ser Val Gly Asp Leu Asp
 1               5                  10                  15      
Tyr Glu Lys Ser
            20  


<210> 4571
<211> 36
<212> PRT
<213> Homo sapiens

<400> 4571
Lys Lys Asn Gly Asn Val Ser Cys Tyr Asn Cys Gly Val Ser Gly His
 1               5                  10                  15      
Tyr Ala Gln Asp Cys Lys Gln Ser Ser Met Glu Ala Asn Gln Gln Gly
            20                  25                  30          
Thr Tyr Arg Leu
        35      


<210> 4572
<211> 32
<212> PRT
<213> Homo sapiens

<400> 4572
Arg Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser
 1               5                  10                  15      
Val Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val
            20                  25                  30          


<210> 4573
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4573
Tyr Ser Leu Asn Val Thr Tyr Gly Gly His Gln Val Pro Gly Ser Pro
 1               5                  10                  15      
Phe Lys Val
            


<210> 4574
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4574
Val Asn Gly Ser Leu Phe Ser Glu Thr Ala Glu Lys Ser
 1               5                  10              


<210> 4575
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4575
Thr Leu Lys Asn Leu Lys Asn Gly Ser Val Lys Lys Gly Gln Pro Val
 1               5                  10                  15      
Asp Pro Ala Ser Val Leu Leu Lys His
            20                  25  


<210> 4576
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4576
Ser His Pro Gln Gly Asn Tyr Ser Asn Ser Lys Leu
 1               5                  10          


<210> 4577
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4577
Arg Val Asn Glu Gln Asn Asn Asp Asn Glu Thr Ala Leu His Cys
 1               5                  10                  15  


<210> 4578
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4578
Arg Val Gly Glu Asn Leu Ser Ala Gly Gln Gly Gly Leu Gln Ile
 1               5                  10                  15  


<210> 4579
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4579
Arg Ser Thr Gly Tyr Cys Ser Val Thr Gly Asn Leu Ser Gly Cys Lys
 1               5                  10                  15      
Gly Ser
        


<210> 4580
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4580
Arg Asn Asn Arg Asn Gln Ser Ile Ile Val Ser Gly Glu Ser Gly Ala
 1               5                  10                  15      
Gly Lys Thr Val Ser Ala Arg Tyr Ala Met Arg Tyr
            20                  25              


<210> 4581
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4581
Arg Asn Ser Ser His Ala Gly Ala Phe Val Ile Val Thr Glu Glu Ala
 1               5                  10                  15      
Ile Ala Lys Gly
            20  


<210> 4582
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Any Amino Acid

<400> 4582
Arg Asn Phe Ser Val Trp Leu Gly Xaa Ser Val Cys Ser
 1               5                  10              


<210> 4583
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4583
Arg Asn Ala Ser Ile Trp Leu Gly Cys Gly His
 1               5                  10      


<210> 4584
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4584
Arg Glu Val Asp Pro Leu Ile Tyr Asn Met Ser His Glu Asp
 1               5                  10                  


<210> 4585
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4585
Pro Ala Asn Val Ser Ala Ser Lys Gly Arg Leu
 1               5                  10      


<210> 4586
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4586
Asn Tyr Asn Ser Ser Met Leu Ser Leu Ser Pro Glu Arg Thr
 1               5                  10                  


<210> 4587
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4587
Met Gln Glu Tyr Glu Glu Gln Leu Lys Glu Asn Ala Ser Glu Gly Lys
 1               5                  10                  15      
Gly
    


<210> 4588
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4588
Met Pro Lys Gly Ala Thr Cys Phe Glu Cys Asn Ile Thr Phe Asn Asn
 1               5                  10                  15      
Leu Asp Asn Tyr Leu Val His Lys Lys His
            20                  25      


<210> 4589
<211> 36
<212> PRT
<213> Homo sapiens

<400> 4589
Met Glu Phe Pro Cys Ser Thr Asp Glu Cys Ile Pro Ser Leu Leu Leu
 1               5                  10                  15      
Cys Asp Gly Val Pro Asp Cys His Phe Asn Glu Asp Glu Leu Ile Cys
            20                  25                  30          
Ser Asn Lys Ser
        35      


<210> 4590
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4590
Leu Gln Leu Glu Thr Ile Asn Val Thr Met Ala Gly Lys Glu
 1               5                  10                  


<210> 4591
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4591
Leu Leu Asp Val Val Asp Lys Asn Glu Ser Ala Val Ile Val Ala Pro
 1               5                  10                  15      
Thr Ser Ser Gly Lys Thr
            20          


<210> 4592
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4592
Leu Lys Asn Val Ser Asp Gly Asp Lys Trp
 1               5                  10  


<210> 4593
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4593
Leu Glu Asn Ser Thr Met Thr Ala Ala Ile Lys Asp
 1               5                  10          


<210> 4594
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4594
Lys Tyr Pro Asn Pro Met Asn Pro Ser Val Val Gly Val Asp Val Leu
 1               5                  10                  15      
Asp Arg His
            


<210> 4595
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4595
Lys Tyr Leu Ala Leu Glu Lys Asn Asp Ser Gln Asn Leu Pro Ile Tyr
 1               5                  10                  15      
Pro Ser Glu Asp Asp Ile Glu Lys Ser Ile Ile
            20                  25          


<210> 4596
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4596
Lys Val Thr Asp Asp Thr Asn Val Thr Arg
 1               5                  10  


<210> 4597
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4597
Lys Val Asn Asn Gly Ser Asn Val Glu Asn Asp Ile Gln
 1               5                  10              


<210> 4598
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4598
Lys Val Met Asn Met Glu Glu Ser Asn Asn Gly Ser Leu
 1               5                  10              


<210> 4599
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4599
Lys Val Leu Glu Val Gln Val Val Asn Gln Thr Ser Val His Val
 1               5                  10                  15  


<210> 4600
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4600
Lys Val Glu Lys Pro Ser Pro Ser Thr Thr Asn Pro His Met Asn Gln
 1               5                  10                  15      
Ser Ser Asn Tyr Leu
            20      


<210> 4601
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4601
Lys Val Ala Asn Cys Ser Leu Gly Thr Ala Thr
 1               5                  10      


<210> 4602
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4602
Lys Gln Asn Thr Ser Cys Ser Lys Asn
 1               5                  


<210> 4603
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4603
Lys Asn Lys Val Leu Ser Asn Asn Ala Ser Ser Gln Lys Pro
 1               5                  10                  


<210> 4604
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4604
Lys Asn Lys Gly Thr Ser Asp Ser Ser Ser Gly Asn Val Ser Glu Gly
 1               5                  10                  15      
Glu Ser Pro Pro Asp Ser
            20          


<210> 4605
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4605
Lys Asn Asn Thr Met Val Tyr Asn Gly Met Asn Met Glu Ala Ile His
 1               5                  10                  15      
Val Leu Leu Asn Phe
            20      


<210> 4606
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4606
Lys Asn Lys Ser Gly Ser Leu Glu Phe Ser Ile Ala Gly Gln Pro Asn
 1               5                  10                  15      
Asp Phe Phe
            


<210> 4607
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4607
Lys Met Asn Phe Ser Thr Leu Arg Asn Ile Gln Gly Leu Phe Ala
 1               5                  10                  15  


<210> 4608
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4608
Lys Leu Thr Phe Phe Asn Ser Thr Leu Asn Thr Ser Gly Leu Val Pro
 1               5                  10                  15      
Glu Gly Asp Ala Leu Pro Ile Pro Gly Ala His
            20                  25          


<210> 4609
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4609
Lys Leu Lys Leu Thr His Ser Glu Asn Ser Ser Leu Tyr Met Ala Leu
 1               5                  10                  15      
Asn Thr Leu Gln
            20  


<210> 4610
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4610
Lys Lys Arg Asn Leu Asp Thr Gly Gly Asn Lys Ser Val
 1               5                  10              


<210> 4611
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4611
Lys Lys Arg Asn Arg Thr Lys Ala
 1               5              


<210> 4612
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4612
Lys Lys Gln Ala Gln Ala Asn Gly Val Ser His Asn Ile Thr Phe Glu
 1               5                  10                  15      
Ser Pro
        


<210> 4613
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4613
Lys Lys Asn Val Thr Glu Met Ala Met Asn Pro His Ile Lys Gln
 1               5                  10                  15  


<210> 4614
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4614
Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe Asn Met Thr Lys Lys
 1               5                  10                  15      
Lys
    


<210> 4615
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4615
Lys Phe Ser Asn Glu Gln Gly Leu Pro Gly Ser Asn Ala Ser Leu Tyr
 1               5                  10                  15      
Leu
    


<210> 4616
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4616
Lys Glu Asn Arg Ser Leu Glu Thr Lys Tyr
 1               5                  10  


<210> 4617
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4617
Lys Ala Gln Ser Asn Gly Ser Gly Asn Gly Ser Asp Ser Glu Met Asp
 1               5                  10                  15      
Thr
    


<210> 4618
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4618
Lys Ala Asn Thr Thr Asp Phe Gly Leu
 1               5                  


<210> 4619
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4619
Lys Ala Asn Thr Ser Ser Ser Ser Ser Asn Ser Ser
 1               5                  10          


<210> 4620
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4620
Lys Ala Asn Asn Ser Gln Glu Pro Ser Pro Gln Leu Ala
 1               5                  10              


<210> 4621
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4621
Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu
 1               5                  10      


<210> 4622
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4622
Lys Ala Ile Asn Phe Ser Trp Arg Thr
 1               5                  


<210> 4623
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4623
Lys Ala Ala Asn Arg Thr Pro Pro Lys Ser
 1               5                  10  


<210> 4624
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4624
Ile Ser Gly Asn Gly Glu Cys Ser Asn Ser Ser Gly Thr Gly Lys Thr
 1               5                  10                  15      


<210> 4625
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4625
Ile Lys Ser Asn Ser Ser Gly Ser Thr Gly Gly Gly Asp Met Gln Pro
 1               5                  10                  15      
Ser Leu Arg Gly
            20  


<210> 4626
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4626
Ile Cys Ser Lys Thr Thr His Cys Val Leu Ala Phe Asn Ala Ser Asp
 1               5                  10                  15      
Lys Ile
        


<210> 4627
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4627
His Lys Asn Val Ser Ser Pro Phe Ile
 1               5                  


<210> 4628
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4628
Gly Tyr Asn Gln Glu Asp Ser Val Ile Met Asn Arg Ser Ala Val Asp
 1               5                  10                  15      
Arg Gly
        


<210> 4629
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4629
Gly Asn Tyr Ser Phe Gly Thr Gln Thr Ile Leu Asn Ser Met His Lys
 1               5                  10                  15      
Tyr
    


<210> 4630
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4630
Gly Asn Leu Ser Thr Tyr Phe Asp Met Asn Leu Phe Leu Asp Ile Ile
 1               5                  10                  15      
Leu Lys Thr
            


<210> 4631
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4631
Gly Gly Leu Ala Asn Asp Ser Glu Asp Pro Lys Asn
 1               5                  10          


<210> 4632
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4632
Glu Glu Ala Leu Ile Lys Asn Asn Asn Thr Cys Lys Asp
 1               5                  10              


<210> 4633
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4633
Asp Ala Gly Asn Asp Ser Ala Ser Thr Ala Pro Arg Ser
 1               5                  10              


<210> 4634
<211> 35
<212> PRT
<213> Homo sapiens

<400> 4634
Cys Leu Cys Cys Gly Cys Glu Val Arg Glu His Leu Ser His Gly Asn
 1               5                  10                  15      
Leu Thr Val Leu Tyr Gly Gly Leu Leu Glu His Leu Ala Ser Pro Glu
            20                  25                  30          
His Lys Lys
        35  


<210> 4635
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4635
Ser Asn Tyr Ser Val Ser Leu Val Gly Pro Ala Pro
 1               5                  10          


<210> 4636
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4636
Met Gly Asn Gly Thr Glu Glu Asp Tyr Asn Phe Val Phe Lys Val
 1               5                  10                  15  


<210> 4637
<211> 33
<212> PRT
<213> Homo sapiens

<400> 4637
Met Asp Ala Gly Val Thr Glu Ser Gly Leu Asn Val Thr Leu Thr Ile
 1               5                  10                  15      
Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys
            20                  25                  30          
Gly
    


<210> 4638
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4638
Thr Ala Pro Pro Leu Ile Asn Gly Thr Ala Glu Val Tyr Ile Pro Arg
 1               5                  10                  15      
Asn
    


<210> 4639
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4639
Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu Asn
 1               5                  10                  15      
Asn Arg Arg Thr
            20  


<210> 4640
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4640
Ser Ala Phe Asn Thr Ser Val His Ala Ala Ile Arg His
 1               5                  10              


<210> 4641
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4641
Arg Lys Leu Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu
 1               5                  10                  15      
Tyr Cys
        


<210> 4642
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4642
Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys
 1               5                  10              


<210> 4643
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4643
Arg His Asn Phe Thr Ala Ser Leu Leu Thr Leu Arg Ile
 1               5                  10              


<210> 4644
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4644
Met Ala Pro Gln Asn Val Ser Ala Ser Lys Lys Arg
 1               5                  10          


<210> 4645
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4645
Leu Asp Asp Leu Gly Thr Val Tyr Gly Asn Ile His Gln Gln Leu Asn
 1               5                  10                  15      
Glu Thr Met Arg Arg
            20      


<210> 4646
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4646
Lys Gln Ala Asp Asn Asp Thr Ile Asp Tyr Ser
 1               5                  10      


<210> 4647
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4647
Lys Gly Asn Ala Thr His Asp Asn Ile Cys Ser Gly Asn Ser Glu Ser
 1               5                  10                  15      
Thr Gln Lys Cys
            20  


<210> 4648
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4648
Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro
 1               5                  10                  15  


<210> 4649
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4649
Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe
 1               5                  10                  15      
Leu Phe Ile Leu Leu Thr Met Lys Gln
            20                  25  


<210> 4650
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4650
Leu Thr Asp Val Leu Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys
 1               5                  10                  15      
Ser
    


<210> 4651
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4651
Lys Ala Arg Gly Arg Val Val Asn Val Ser Ser Val Met Gly Arg Val
 1               5                  10                  15      
Ser Leu
        


<210> 4652
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4652
Arg Tyr Asn His Thr Gly Gln Val Ile Ile Tyr Arg Met
 1               5                  10              


<210> 4653
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4653
Arg Tyr Lys Glu Gly Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn
 1               5                  10                  15      
Val Thr Lys Tyr
            20  


<210> 4654
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4654
Arg Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp
 1               5                  10                  15      
Lys Glu
        


<210> 4655
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4655
Arg Val Glu Asn Thr Ser His Pro Gly Glu Met Gln Val Thr
 1               5                  10                  


<210> 4656
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4656
Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro Met Gly
 1               5                  10                  


<210> 4657
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4657
Arg Asn Ile Ser Thr Ala Thr Ala Ala Gln Thr Asp Leu Asn Phe
 1               5                  10                  15  


<210> 4658
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4658
Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala
 1               5                  10                  15  


<210> 4659
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4659
Arg Leu Asn Ser Ser Thr Ile Lys Tyr
 1               5                  


<210> 4660
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4660
Arg Ile Asn Tyr Ser Cys Thr Thr Gly Phe
 1               5                  10  


<210> 4661
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4661
Arg Gly Arg Pro Asn Ile Thr His Ala Val Pro Lys Ala
 1               5                  10              


<210> 4662
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4662
Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg
 1               5                  10                  15      
Lys
    


<210> 4663
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4663
Arg Phe Leu Val Thr Ala Pro Gly Ile Ile Arg Pro Gly Gly Asn Val
 1               5                  10                  15      
Thr Ile Gly Val Glu
            20      


<210> 4664
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4664
Arg Glu Asn Asn Asn Ile Thr Met Arg Val
 1               5                  10  


<210> 4665
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4665
Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly
 1               5                  10              


<210> 4666
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4666
Arg Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly
 1               5                  10                  


<210> 4667
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4667
Pro Asn Thr Phe Asn Val Thr Val Leu His Gly Ser Lys Ile
 1               5                  10                  


<210> 4668
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4668
Pro Leu Gly Pro Leu Gln Val Tyr Cys Asn Ile Thr Glu Asp Lys Ile
 1               5                  10                  15      


<210> 4669
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4669
Leu Asn Leu Glu Ala Asn Val Thr Ala Asp Gly Ala Leu Ala Met Glu
 1               5                  10                  15      
Lys Gly
        


<210> 4670
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4670
Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg
 1               5                  10          


<210> 4671
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4671
Lys Thr Val Thr Thr Ser Gly Thr Thr Asn Asn Thr Val Thr Pro Thr
 1               5                  10                  15      
Ser Gln Pro Val Arg Lys
            20          


<210> 4672
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4672
Lys Thr Cys Thr Glu Phe His Asn Cys Thr Glu Cys Arg Asp
 1               5                  10                  


<210> 4673
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4673
Lys Thr Cys Asp Trp Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys
 1               5                  10                  15      
Glu
    


<210> 4674
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4674
Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn Glu Cys Leu
 1               5                  10                  15  


<210> 4675
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4675
Lys Asn Leu Ser Leu Thr Phe Pro Thr Ser Gly Gly Ser Arg Cys
 1               5                  10                  15  


<210> 4676
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4676
Lys Leu Thr Gly Gly Gly Gly Asn Val Thr Leu
 1               5                  10      


<210> 4677
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4677
Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys Asn Leu Thr
 1               5                  10                  15      
Ile Thr Ser Arg Phe
            20      


<210> 4678
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4678
Lys Ile Val Tyr Asn Ile Thr Leu Pro Leu His Pro Asn Gln Gly Ile
 1               5                  10                  15      
Ile
    


<210> 4679
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4679
Lys Phe Asn Leu Ser His Leu Gly Ser Lys Glu
 1               5                  10      


<210> 4680
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4680
Lys Phe Phe Gln Ile Asn Gly Ser Thr Gly Glu Met Ser Thr Val Gln
 1               5                  10                  15      
Glu
    


<210> 4681
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4681
Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn
 1               5                  10  


<210> 4682
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4682
Ile Ser Tyr Val Pro Gln Leu Ser Asn Asp Thr Leu Ala Gly Arg Leu
 1               5                  10                  15      


<210> 4683
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4683
His Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg Val
 1               5                  10              


<210> 4684
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4684
His Met Gln Ser Cys Asn Phe Ser Ala Glu Lys Ala
 1               5                  10          


<210> 4685
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4685
Trp Tyr Asp Cys Thr Trp Asn Asn Asp Thr Lys Thr
 1               5                  10          


<210> 4686
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4686
Trp Val Ser Ile Asn Asn Met Val Asn Asn Ser Trp Gly Lys Gln
 1               5                  10                  15  


<210> 4687
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4687
Val Thr Tyr Glu Ile Glu Thr Asn Gly Thr Phe Gly Ile Gln Lys Val
 1               5                  10                  15      


<210> 4688
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4688
Val Ala Ala Val Gly Asn Gln Thr Ser Asp Phe Lys Asn
 1               5                  10              


<210> 4689
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4689
Arg Tyr Asn Lys Thr Val Thr Tyr Gln Cys
 1               5                  10  


<210> 4690
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4690
Arg Val Leu Gln Gly Leu Leu Met Pro Leu Phe Lys Asn Thr Ser Val
 1               5                  10                  15      
Ser Ser
        


<210> 4691
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4691
Arg Val Asp Phe His Asn Phe Ser Lys Thr
 1               5                  10  


<210> 4692
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4692
Arg Arg Pro Ala Gly Gly Asn Ser Ser Gly Gln Ser Asp Asn Cys Ser
 1               5                  10                  15      
Ser Ser Ser Glu Ala Asn Gly
            20              


<210> 4693
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4693
Arg Arg Asn Ile Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg
 1               5                  10                  15      
Arg
    


<210> 4694
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4694
Arg Arg Asn Glu Ser His Leu Ile Asp Phe Arg Glu
 1               5                  10          


<210> 4695
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4695
Arg Gln Asn Gly Gln Leu Val Arg Asn Asp Ser Leu Val Thr Pro Ser
 1               5                  10                  15      
Pro Gln Gln Ala Arg Val Cys Pro
            20                  


<210> 4696
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4696
Arg Asn Asn Thr Asn Asn Trp Arg Glu
 1               5                  


<210> 4697
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4697
Arg Asn Asn Ser Asp Cys Pro Arg Val
 1               5                  


<210> 4698
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4698
Arg Asn Ile Thr Ala Val Ala Gly Arg Asp
 1               5                  10  


<210> 4699
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4699
Arg Asn Gly Thr Glu Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro
 1               5                  10                  15      
Val Tyr
        


<210> 4700
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4700
Arg Asn Gly Ser Asn Asp Ala Ser Leu Asp Ser Gly Val Asp Met Asn
 1               5                  10                  15      
Glu Pro Lys Ser Ala
            20      


<210> 4701
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4701
Arg Leu Ser His Asn Cys Ile Ser Gln Ala Val Asn Gly Ser Gln Phe
 1               5                  10                  15      
Leu Pro Leu Thr Gly
            20      


<210> 4702
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4702
Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile Gln
 1               5                  10                  15      
Ser Tyr Phe Lys Ser Gln
            20          


<210> 4703
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4703
Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala Ile Arg Val
 1               5                  10                  15  


<210> 4704
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4704
Arg Ile Asn Leu Thr Val Pro Gln Gly Cys Leu Leu Ala Val Val Gly
 1               5                  10                  15      
Pro Val Gly
            


<210> 4705
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4705
Arg Ile Gly Glu Pro Ala Asn Val Thr Ala Ile Val Ser Leu Tyr Gly
 1               5                  10                  15      
Glu Asp
        


<210> 4706
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4706
Arg Gly Glu Pro Ser Asn Glu Pro Ser Thr Glu Thr Asn Lys Thr Gln
 1               5                  10                  15      
Glu Gln Ser
            


<210> 4707
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4707
Arg Glu Asn Asn Ser Pro Ala Leu Pro Ile Gly
 1               5                  10      


<210> 4708
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4708
Arg Glu Ala Arg Ala Glu Tyr Asn Ile Thr Leu Thr Val Thr Asp Met
 1               5                  10                  15      
Gly Thr Pro Arg Leu
            20      


<210> 4709
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4709
Arg Ala Ile Pro Phe Gly Thr Met Val Ser Cys Leu Asn Leu Thr Phe
 1               5                  10                  15      
Lys Leu
        


<210> 4710
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4710
Gln Met Ala Ala Leu Gln Gly Asn Gly Ser Glu Arg Thr
 1               5                  10              


<210> 4711
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4711
Gln Asp Phe Val Asp Ser Phe Tyr Asn Leu Thr Leu Lys Leu
 1               5                  10                  


<210> 4712
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4712
Pro Ser Arg Met Ala Thr Gln Ala Ser Thr Leu Tyr Ser Asn Asn Ile
 1               5                  10                  15      
Thr Lys Leu
            


<210> 4713
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4713
Asn Val Tyr Phe Asn Cys Ser Gly Ala Ser Tyr Ser Arg Glu
 1               5                  10                  


<210> 4714
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4714
Met Glu Leu Asn Ser Ser Ser Gly Gly Glu Gly Lys Thr
 1               5                  10              


<210> 4715
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4715
Leu Ser Leu Val Gly Cys Tyr Asn Leu Ser Phe Ile Pro Glu Gly Lys
 1               5                  10                  15      
Arg
    


<210> 4716
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4716
Leu Phe Met Ile Ile Leu Ser Gly Asn Leu Ser Ile Ile Ile Leu Ile
 1               5                  10                  15      
Arg Ile
        


<210> 4717
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4717
Leu Glu Asn Ala Thr Gly Gln Asp Cys Thr Ser Gln Pro Arg Leu
 1               5                  10                  15  


<210> 4718
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4718
Lys Trp Pro Ala Asp Lys Glu Asn Asp Thr Gly Ile Val Gly Gln His
 1               5                  10                  15      


<210> 4719
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4719
Lys Val Gly Ile Arg Lys Leu Ile Asn Asn Gly Ser Tyr Ile Ala Ala
 1               5                  10                  15      
Phe Pro Pro His Glu Gly
            20          


<210> 4720
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4720
Lys Thr Leu Asn Ala Ser Phe His Trp
 1               5                  


<210> 4721
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4721
Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His
 1               5                  10                  15      


<210> 4722
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4722
Lys Gln Ser Leu Thr His Gly Ser Ser Gly Tyr Ile Asn Ser Thr Gly
 1               5                  10                  15      
Ser Thr Arg Gly
            20  


<210> 4723
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4723
Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys
 1               5                  10          


<210> 4724
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4724
Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser Asn Gly Glu Leu Arg
 1               5                  10                  15      


<210> 4725
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4725
Lys Leu Gly Gly Phe Thr Gln Glu Asn Asn Thr Ile Asp Ser Gly Glu
 1               5                  10                  15      
Leu Asp Ile Gly Arg Arg Ala
            20              


<210> 4726
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4726
Lys Lys Ser Ile Ala His Asn Met Thr Thr Pro Asn Lys Leu
 1               5                  10                  


<210> 4727
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4727
Lys Ile Met Ala Leu Phe Ser Ala Asn Ser Ile Gly Ala Met Asn Asn
 1               5                  10                  15      
Ser Asp Thr
            


<210> 4728
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4728
Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His Val Ser
 1               5                  10                  15  


<210> 4729
<211> 33
<212> PRT
<213> Homo sapiens

<400> 4729
Lys Asp Asp Asp Ser Leu Leu His Pro Gly Asn Leu Thr Ser Thr Ser
 1               5                  10                  15      
Asp Asp Ala Ser Arg Leu Glu Ala Gly Gly Glu Thr Val Pro Glu Arg
            20                  25                  30          
Asn
    


<210> 4730
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4730
Lys Ala Phe Val Glu Ile Ile Asn Ser Thr His Ala
 1               5                  10          


<210> 4731
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4731
Phe Thr Val Gly Asp Asn Arg Thr Tyr Gln Gly Phe Trp Asn Pro Pro
 1               5                  10                  15      
Leu Ala Pro Arg Lys
            20      


<210> 4732
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4732
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Gly Glu Asp Met
 1               5                  10                  15      
Arg His
        


<210> 4733
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4733
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Lys Tyr
 1               5                  10          


<210> 4734
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4734
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu His Tyr Glu Glu Asn Met
 1               5                  10                  15      
Gln His Pro Gly Ser Arg Lys
            20              


<210> 4735
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4735
Ala Pro Trp Glu Ala Ala Gly Asn Arg Ser Asn Ser Ser Gly Ala Asp
 1               5                  10                  15      
Gly Gly Asp Thr Pro Pro Leu Pro Ser Pro Pro Asp Lys Gly
            20                  25                  30  


<210> 4736
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4736
Ala Asn Ser Gly Ser Asn Ser Ser Gly Ala Thr Arg Ala
 1               5                  10              


<210> 4737
<211> 32
<212> PRT
<213> Homo sapiens

<400> 4737
Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe Leu Gly Pro
 1               5                  10                  15      
Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val Asn Lys Ser
            20                  25                  30          


<210> 4738
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4738
Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys Glu
 1               5                  10                  


<210> 4739
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4739
Arg Val Glu Leu Ala Pro Leu Pro Pro Trp Gln Pro Val Gly Gln Asn
 1               5                  10                  15      
Phe Thr Leu Arg Cys
            20      


<210> 4740
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4740
Lys Glu Leu Val Ala Ser Gly Met Gly Trp Ala Ala Phe Asn Leu Ser
 1               5                  10                  15      
Asn Val Thr Gly Asn Ser Arg Ile
            20                  


<210> 4741
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4741
Arg Met Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln
 1               5                  10                  15      
Gly Ile Arg Phe
            20  


<210> 4742
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4742
Lys Val Val Thr Gln Asn Ser Ser Ser Gly Asn Val Thr His Glu Lys
 1               5                  10                  15      
Ile
    


<210> 4743
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4743
Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr
 1               5                  10                  15      
Ile Leu Asp Lys Val
            20      


<210> 4744
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4744
Lys Tyr Val Ile Asn Gly Thr Tyr Ala Asn Glu Thr Lys Leu
 1               5                  10                  


<210> 4745
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4745
Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro Arg
 1               5                  10                  15      
Gln
    


<210> 4746
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4746
Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr
 1               5                  10  


<210> 4747
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4747
Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn
 1               5                  10                  15      
Leu Phe Ile Asn Asn Leu Asn Lys Thr
            20                  25  


<210> 4748
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4748
Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu
 1               5                  10                  15      
Ser Val Asn Arg Thr
            20      


<210> 4749
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4749
Arg Asp Ala Thr Gly Asn Val Asn Asp Thr Ile Val Thr Glu Leu Thr
 1               5                  10                  15      
Asn Cys Thr Ser Ala Ala Cys Lys Leu
            20                  25  


<210> 4750
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4750
Lys Glu Leu Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn
 1               5                  10                  15      
Tyr Ser Arg Cys
            20  


<210> 4751
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4751
Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg Asn Glu
 1               5                  10                  15      
Ser His Lys Asn
            20  


<210> 4752
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4752
Arg Ala Ala Asn Tyr Thr Ser Ser Leu Asn Leu Pro Asp Lys Thr
 1               5                  10                  15  


<210> 4753
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4753
Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn Leu Thr Ile Thr Met His
 1               5                  10                  15      
Arg Leu
        


<210> 4754
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4754
Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr Ile Leu Asn Gly Ser Asp
 1               5                  10                  15      
Ile Arg Ser
            


<210> 4755
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4755
Lys Glu Thr Asn Phe Ser Leu Ala Ser Gly Leu Glu Ala Lys Asp
 1               5                  10                  15  


<210> 4756
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4756
Lys Glu Gly Lys Pro Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala
 1               5                  10                  15      
Phe Trp Thr Lys Gln
            20      


<210> 4757
<211> 31
<212> PRT
<213> Homo sapiens

<400> 4757
Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met
 1               5                  10                  15      
Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His
            20                  25                  30      


<210> 4758
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4758
Lys Ala Asp Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu
 1               5                  10                  15      
Asn Gly Ser Leu Pro Lys Gly
            20              


<210> 4759
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4759
Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His
 1               5                  10                  


<210> 4760
<211> 29
<212> PRT
<213> Homo sapiens

<400> 4760
Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser Leu Phe
 1               5                  10                  15      
Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile
            20                  25                  


<210> 4761
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4761
Arg Thr Asp Gly Leu Ala Trp Leu Gly Glu Leu Gln Thr His Ser Trp
 1               5                  10                  15      
Ser Asn Asp Ser Asp Thr Val Arg Ser
            20                  25  


<210> 4762
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4762
Arg Gly Asn Val Thr Gln His Val Gln Gly His Arg Asn
 1               5                  10              


<210> 4763
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4763
Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu Lys Gln
 1               5                  10                  15      


<210> 4764
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4764
Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn Gly Ser Ile Leu
 1               5                  10                  15      
Pro Ile Ser Trp Arg Trp
            20          


<210> 4765
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4765
Arg Ile Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser
 1               5                  10                  15      
Thr Glu Phe Val Ser Leu Ala Ser Lys Val
            20                  25      


<210> 4766
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4766
Lys Ala Pro Gln His Val Val Asn His Leu Pro Pro Tyr Thr Asn Val
 1               5                  10                  15      
Ser Leu Lys Met
            20  


<210> 4767
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4767
Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala
 1               5                  10                  15      
Lys Ile
        


<210> 4768
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4768
Arg Gln Asp Val Asn Ile Thr Val Ala Thr Val Pro Ser Trp Leu Lys
 1               5                  10                  15      
Lys
    


<210> 4769
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4769
Phe Leu Ile Gly Asn Asp Ser Tyr Pro Ile Pro Ile Ala Leu Lys Lys
 1               5                  10                  15      


<210> 4770
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4770
Lys Gly Asn Phe Ser Asn Glu Glu Leu Ser Asp Leu Glu Leu Leu Phe
 1               5                  10                  15      
Arg Phe
        


<210> 4771
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4771
Asp Thr Asn Thr Thr Ile Ile Gln Leu Gln Pro Leu Gln Glu Pro Glu
 1               5                  10                  15      
Ser Trp Ala Arg Thr
            20      


<210> 4772
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4772
Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp
 1               5                  10                  15  


<210> 4773
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4773
Arg Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn
 1               5                  10                  15      
Gly Thr Tyr Arg Cys
            20      


<210> 4774
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4774
Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
 1               5                  10              


<210> 4775
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4775
Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile
 1               5                  10      


<210> 4776
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4776
Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys
 1               5                  10                  15      


<210> 4777
<211> 31
<212> PRT
<213> Homo sapiens

<400> 4777
Lys Val Ser Ser Ile Val Val Asn Ile Thr Glu Leu Phe Ser Lys Pro
 1               5                  10                  15      
Glu Leu Glu Ser Ser Phe Thr His Leu Asp Gln Gly Glu Arg Leu
            20                  25                  30      


<210> 4778
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4778
Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val
 1               5                  10      


<210> 4779
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4779
Arg Leu Ser Ala Val Asn Ser Ile Phe Leu Ser His Asn Asn Thr Lys
 1               5                  10                  15      
Glu
    


<210> 4780
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4780
Arg Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp
 1               5                  10                  15      
Asn Gln Asn Leu Arg Gln
            20          


<210> 4781
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4781
Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser Met Ala Asp
 1               5                  10                  15      
Arg Lys
        


<210> 4782
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4782
Phe Ser Ser Gly Asp Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser
 1               5                  10                  15      
Arg Ile
        


<210> 4783
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4783
Lys Leu Ser His Asp Ala Asn Glu Thr Leu Pro Leu His Leu Tyr Val
 1               5                  10                  15      
Lys Ser
        


<210> 4784
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4784
Arg Asn Pro Asn Gly Thr Val Thr Val Ile Ser Arg Tyr
 1               5                  10              


<210> 4785
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4785
Arg Thr Asn Ala Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala
 1               5                  10                  15      
Ser Asn Ser Ser Ser Gln Leu Ile Val Lys Trp
            20                  25          


<210> 4786
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4786
Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile
 1               5                  10          


<210> 4787
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4787
Lys Cys Gln Asn Cys Phe Pro Leu Asn Trp Thr Trp Tyr Ser Ser Asn
 1               5                  10                  15      
Gly Ser Val Lys Val
            20      


<210> 4788
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4788
Arg Val Tyr Asn Val Thr Gln His Ala Val Gly Ile Val Val Asn Lys
 1               5                  10                  15      
Gln
    


<210> 4789
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4789
Lys Ile Asn Ser Ser Val Thr Asp Ile Glu Glu Ile Ile Gly Val Arg
 1               5                  10                  15      
Ile
    


<210> 4790
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4790
Lys Gly Glu Pro Ala Ile Phe Asn Leu Ser Ile Thr Glu Ala His Glu
 1               5                  10                  15      
Ser Gly Pro Tyr Lys Cys
            20          


<210> 4791
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4791
Arg Asn Ser Ser Phe His Leu Asn Ser Glu Thr Gly Thr Leu Val Phe
 1               5                  10                  15      
Thr Ala Val His Lys Asp
            20          


<210> 4792
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4792
Arg Ile Asp Pro Val Thr Gly Asn Ile Thr Leu Glu Glu Lys Pro Ala
 1               5                  10                  15      
Pro Thr Asp Val Gly Leu His Arg Leu
            20                  25  


<210> 4793
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4793
Arg Gly Asn Phe Ser Asn Glu Glu Trp Lys Glu
 1               5                  10      


<210> 4794
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4794
Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser
 1               5                  10                  15      
Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser
            20                  25              


<210> 4795
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4795
Lys Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val
 1               5                  10                  15      
Phe Glu Lys Gly
            20  


<210> 4796
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4796
Arg Tyr His Ser Asp Asn Ser Thr Lys Ala
 1               5                  10  


<210> 4797
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4797
Arg Leu Ala Thr Ile Ala Asn Phe Ser Ala Leu Gly Leu Glu Pro Gly
 1               5                  10                  15      
Arg Asp
        


<210> 4798
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4798
Asn Asn Ala Asn Val Thr Trp Trp Arg Val
 1               5                  10  


<210> 4799
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4799
Lys Gly Val Leu Met Val Gly Asn Glu Thr Thr Tyr Glu Asp Gly His
 1               5                  10                  15      
Gly Ser Arg Lys
            20  


<210> 4800
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4800
Arg Val Gln Gly Asn Ser Thr Leu Leu His Ile Thr Asp Leu Gln Ala
 1               5                  10                  15      
Arg Asp
        


<210> 4801
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4801
Lys Leu His Val Gly Tyr Leu Gln Pro Leu Val Ala Val Gln Val Ser
 1               5                  10                  15      
Phe Ala Pro Asn Asp Thr Gly Lys Glu
            20                  25  


<210> 4802
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4802
Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser Phe Leu Glu
 1               5                  10                  15      
Tyr Arg Thr
            


<210> 4803
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4803
Arg Asn Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg
 1               5                  10                  15      
Arg
    


<210> 4804
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4804
Lys Thr Ile Leu Ser Asn Gln Thr Val Asp Ile Pro Glu Asn Val Asp
 1               5                  10                  15      
Ile Thr Leu Lys Gly
            20      


<210> 4805
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4805
Arg Val Tyr Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu
 1               5                  10                  15      
Phe Phe Arg Asn
            20  


<210> 4806
<211> 36
<212> PRT
<213> Homo sapiens

<400> 4806
Arg Asn Ile Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn Met Thr
 1               5                  10                  15      
Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp Asn Val
            20                  25                  30          
Ser Phe Arg Trp
        35      


<210> 4807
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4807
Arg Leu Phe Ala Leu Asn Asn Thr Thr Gly Leu Ile Thr Val Gln Arg
 1               5                  10                  15      
Ser
    


<210> 4808
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4808
Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp Val Trp Thr Tyr
 1               5                  10                  15      
Ser Asp Thr Arg Cys
            20      


<210> 4809
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4809
Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile
 1               5                  10  


<210> 4810
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4810
Lys Leu Asn Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met
 1               5                  10                  15      
Lys Thr
        


<210> 4811
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4811
Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr
 1               5                  10          


<210> 4812
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4812
Phe Asn Glu Thr Ser Leu Ala Phe Ile Val Pro His Glu Thr Lys Ser
 1               5                  10                  15      


<210> 4813
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4813
Ser Ser Thr Asn Phe Thr Ser Pro Val Ile Glu Phe Trp Glu Arg Asn
 1               5                  10                  15      


<210> 4814
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4814
Arg Val Tyr Gly Gln Asn Ile Asn Asn Glu Thr Trp Ser Arg Ile
 1               5                  10                  15  


<210> 4815
<211> 40
<212> PRT
<213> Homo sapiens

<400> 4815
Arg Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu
 1               5                  10                  15      
Gly Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His
            20                  25                  30          
Cys Leu Pro Val Thr Leu Arg Gly
        35                  40  


<210> 4816
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4816
Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile
 1               5                  10          


<210> 4817
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4817
Asn Thr Ile Phe Tyr Pro Val Glu Ile Asn Glu Ser Glu Pro Ile Val
 1               5                  10                  15      
Val Tyr Asp Lys Glu
            20      


<210> 4818
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4818
Asn Pro Ser Asn Glu Thr Leu Ala Gln Trp Lys Lys
 1               5                  10          


<210> 4819
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4819
Met Gln Val Pro Asn Ser Thr Gly Pro Asp Asn Ala Thr Leu Gln Met
 1               5                  10                  15      
Leu Arg Asn
            


<210> 4820
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4820
Lys Asp Tyr Pro Ala Ser Thr Ser Gln Asp Ser Phe Glu Ala Ala Gly
 1               5                  10                  15      
Asn Ser Thr Ser Gly Ser Arg Ala
            20                  


<210> 4821
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4821
Lys Ala Ser Met Asn Thr Ser Ser Asn Pro Gly Thr Pro Leu Pro Leu
 1               5                  10                  15      
Pro Leu Arg Ile
            20  


<210> 4822
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4822
Arg Leu Ser Gln Ala Gln Gly Asn Leu Ser Val Leu Glu Thr Arg Gln
 1               5                  10                  15      


<210> 4823
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4823
Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly Thr Gln Ser Leu Pro
 1               5                  10                  15      
Thr Asp Val Met Thr Thr Val Phe Lys Val
            20                  25      


<210> 4824
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4824
Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile Leu
 1               5                  10                  15      
Gly Asn Leu Lys Asp
            20      


<210> 4825
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4825
Lys Thr Gly Ala Leu Thr Val Gln Asn Thr Thr Gln Leu Arg Ser
 1               5                  10                  15  


<210> 4826
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4826
Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly
 1               5                  10      


<210> 4827
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4827
Arg Tyr Ile Ile Ser Pro Ile Asn Gly Thr Val Tyr Leu Ser Glu Lys
 1               5                  10                  15      
Asp
    


<210> 4828
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4828
Arg Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser
 1               5                  10                  15  


<210> 4829
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4829
Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr
 1               5                  10  


<210> 4830
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4830
Lys Asn Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly
 1               5                  10                  15      
Gly Ala Tyr Glu Ala Glu Leu Arg Val
            20                  25  


<210> 4831
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4831
Lys Leu Gly Val Thr Asn Ala Ser Leu Val Leu Phe Arg Pro
 1               5                  10                  


<210> 4832
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4832
Lys Gly Asn Phe Ser Asp Lys Glu Val Ala Glu Leu Glu Glu Ile Phe
 1               5                  10                  15      
Arg Val
        


<210> 4833
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4833
Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys
 1               5                  10      


<210> 4834
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4834
Tyr Asn Leu Ser Thr Ala Glu Glu Val Phe Ser His Gly Lys Tyr
 1               5                  10                  15  


<210> 4835
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4835
Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu
 1               5                  10                  15      
Ile Lys Phe
            


<210> 4836
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4836
Arg Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln
 1               5                  10          


<210> 4837
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4837
Arg Leu Ile Asn Ser Thr Phe Leu His Asn Lys Glu
 1               5                  10          


<210> 4838
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4838
Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr Asn Tyr
 1               5                  10                  15      
Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp
            20                  25      


<210> 4839
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4839
Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala Lys Pro Thr Asn Trp
 1               5                  10                  15      
Ile Glu Gly Thr Gln Ala Val Leu Arg Ala
            20                  25      


<210> 4840
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4840
Arg Glu Leu Tyr Asn Gly Thr Ala Asp Ile Thr Leu Arg Phe
 1               5                  10                  


<210> 4841
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4841
Arg Asp Cys Ser Cys Ile Pro Gln Asn Leu Ser Ser Gly Phe Gly His
 1               5                  10                  15      
Ala Thr Ala Gly Lys Cys
            20          


<210> 4842
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4842
Leu Ala Asn Ala Ser Leu Asn Leu His Ser Lys Lys
 1               5                  10          


<210> 4843
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4843
Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys Val
 1               5                  10                  15      


<210> 4844
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4844
Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser
 1               5                  10          


<210> 4845
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4845
Lys Leu Asn Val Thr Thr Ala Trp Lys Ala
 1               5                  10  


<210> 4846
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4846
Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys
 1               5                  10                  15      
Leu
    


<210> 4847
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4847
Lys Glu Tyr Leu Glu Gln Ile Ser Thr Leu Ile Asn Thr Thr Asp Arg
 1               5                  10                  15      
Cys
    


<210> 4848
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4848
Lys Glu Phe Asn Asn Trp Phe Asn Val Thr Gly Ser Asp Lys Cys
 1               5                  10                  15  


<210> 4849
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4849
Ser Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn
 1               5                  10                  15      
Asn Ser Gln Asp Trp Arg Asp
            20              


<210> 4850
<211> 34
<212> PRT
<213> Homo sapiens

<400> 4850
Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser Ala Val Asp Gln
 1               5                  10                  15      
Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn Ser Gln Asp Trp
            20                  25                  30          
Arg Asp
        


<210> 4851
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4851
Lys Val Leu Gly Gln Ser Gln Glu Pro Asn Val Asn Pro Ala Ser Ala
 1               5                  10                  15      
Gly Asn Gln Thr Gln Lys Thr
            20              


<210> 4852
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4852
Arg Ala Pro Ala Asp Leu Pro His Gly Ser Tyr Leu Met Val Asn Thr
 1               5                  10                  15      
Ser Gln His Ala Pro Gly Gln Arg Ala
            20                  25  


<210> 4853
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4853
Arg Asn Ile Ser Gln Val Leu Glu Lys Lys
 1               5                  10  


<210> 4854
<211> 32
<212> PRT
<213> Homo sapiens

<400> 4854
Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn
 1               5                  10                  15      
Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys
            20                  25                  30          


<210> 4855
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4855
Gly Lys Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Thr
 1               5                  10                  


<210> 4856
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4856
Arg Asp Gly Asn Ser Ser Leu Ile Ala Ala Val Ala Glu Val Arg Val
 1               5                  10                  15      


<210> 4857
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4857
Arg Ala Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro
 1               5                  10                  15      
Glu Tyr Asn Lys Asn Thr Ser Lys Phe
            20                  25  


<210> 4858
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4858
Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His Asn
 1               5                  10                  15      
Gly Lys Glu
            


<210> 4859
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4859
Lys Tyr Thr Leu Asp Pro Asn Ile Thr Ser Ala Gly Pro Thr Lys Ser
 1               5                  10                  15      


<210> 4860
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4860
Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro
 1               5                  10          


<210> 4861
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4861
Lys Glu Leu Ser Glu Tyr Asn Ala Thr Ala Ile Lys Ser
 1               5                  10              


<210> 4862
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4862
Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
 1               5                  10      


<210> 4863
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4863
Tyr Leu Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu
 1               5                  10                  15      


<210> 4864
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4864
Ser Val Gly Pro Tyr Ser Phe Leu Val Val Ala Asn Thr Phe Asn Gly
 1               5                  10                  15      
Thr Ser Thr Lys Val
            20      


<210> 4865
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4865
Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro
 1               5                  10                  15      
Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val
            20                  25                  30  


<210> 4866
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4866
Arg Asn Val Ile Ser Asn Ile Asn Glu Thr Ser Val Ile Leu Asp Trp
 1               5                  10                  15      
Ser Trp Pro Leu Asp Thr Gly Gly Arg Lys
            20                  25      


<210> 4867
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4867
Arg Asn Ser Ser Val Gln Leu Arg Val
 1               5                  


<210> 4868
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4868
Arg Gly Thr Asn Val Thr Ile Ser Ser Leu Lys Pro Asp Thr Ile Tyr
 1               5                  10                  15      
Val Phe Gln Ile Arg Ala
            20          


<210> 4869
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4869
Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile Thr Gly Ser
 1               5                  10                  15      
Ile Gln Val Ser Ser Arg Glu
            20              


<210> 4870
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4870
Arg Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu
 1               5                  10          


<210> 4871
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4871
Lys Asn Ala Asp Ile Val Tyr Gln Leu Gly Pro Asn Ala Ser Phe Phe
 1               5                  10                  15      
Asp Leu Asp Arg Lys
            20      


<210> 4872
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4872
Arg Val Trp Asp Thr Ala Val Gly Leu Asn His Thr Ala Glu Pro Ser
 1               5                  10                  15      
Leu Gln Thr Leu Glu Arg Gln
            20              


<210> 4873
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4873
Arg Val Pro Asp Ala Ala Asn Leu Ser Ser Ala Trp Arg Asn
 1               5                  10                  


<210> 4874
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4874
Arg Ser Asn Val Thr Leu Thr Leu Arg Asn
 1               5                  10  


<210> 4875
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4875
Arg Ser Phe Asp Pro Ala Val Pro Val Ala Gly Pro Pro Gln Thr Val
 1               5                  10                  15      
Ser Asn Leu Trp Asn Ser Thr His His
            20                  25  


<210> 4876
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4876
Arg Leu His His His Leu Asp His Asn Asn Thr His His Phe His Asn
 1               5                  10                  15      
Asp Ser Ile Thr Pro Ser Glu Arg Gly
            20                  25  


<210> 4877
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4877
Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro Thr Tyr Pro Asn Ser Thr
 1               5                  10                  15      
Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr Gly Ile Lys Tyr
            20                  25                  30  


<210> 4878
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4878
Arg Ala Leu Tyr Glu Leu Ala Gly Gly Thr Asn Phe Ser Asp Thr Val
 1               5                  10                  15      
Gln Ala Asp Pro Gln Thr Val Thr Arg Leu
            20                  25      


<210> 4879
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4879
Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser
 1               5                  10                  15      
Asn Ala Glu Arg Lys
            20      


<210> 4880
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4880
Lys Val Val Trp Leu Phe Asn Thr Ser Ile Ile Ser Lys Glu
 1               5                  10                  


<210> 4881
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4881
Lys Val Gly Ser Thr Asn Val Ser Thr Leu Val Asn Val His Phe Ala
 1               5                  10                  15      
Pro Arg Ile
            


<210> 4882
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4882
Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met
 1               5                  10          


<210> 4883
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4883
Lys Met Thr Ala Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val
 1               5                  10                  15      
Asn Ile Thr Glu Phe Tyr Asn Lys Ser
            20                  25  


<210> 4884
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4884
Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu Ala Asp Asp Gly
 1               5                  10                  15      
Lys Arg
        


<210> 4885
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4885
Lys Glu Asn Thr Ser Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe
 1               5                  10                  15      
Arg Lys
        


<210> 4886
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4886
Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly
 1               5                  10                  


<210> 4887
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4887
Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg
 1               5                  10              


<210> 4888
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4888
Glu Asp Phe Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr
 1               5                  10                  15      
Lys Val
        


<210> 4889
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4889
Asp Ala Thr Asn Pro Ser Val Pro Leu Asp Pro Ile Ser Val Ser Asn
 1               5                  10                  15      
Ser Ser Ser Gln Ile Ile Leu Lys Trp
            20                  25  


<210> 4890
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4890
Arg Lys Asp Asn Thr Thr Val Thr Arg Leu
 1               5                  10  


<210> 4891
<211> 37
<212> PRT
<213> Homo sapiens

<400> 4891
Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu
 1               5                  10                  15      
Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr
            20                  25                  30          
Asp Thr Met Lys Phe
        35          


<210> 4892
<211> 29
<212> PRT
<213> Homo sapiens

<400> 4892
Lys His Phe His Ser His Asn His Gln His Ser His Asn His Leu Asn
 1               5                  10                  15      
Ser Glu Asn Gln Thr Val Thr Ser Val Ser Thr Lys Arg
            20                  25                  


<210> 4893
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4893
Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp Ser Ser Gly Pro
 1               5                  10                  15      
Glu Arg Ile
            


<210> 4894
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4894
Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala
 1               5                  10                  


<210> 4895
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4895
Arg Gly Ser Glu Gly Gly Asn Gly Ser Asn Pro Val Ala Gly Leu Glu
 1               5                  10                  15      
Thr Asp Asp His Gly Gly Lys Ala
            20                  


<210> 4896
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4896
Lys Ser Leu Glu Asp Leu Ile Phe Glu Ser Leu Pro Glu Asn Ala Ser
 1               5                  10                  15      
His Lys Leu
            


<210> 4897
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4897
Lys Val Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys
 1               5                  10                  15      
Trp
    


<210> 4898
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4898
Arg Glu Gly Ser Gly Tyr Phe Phe Leu Asn Thr Ser Thr Ala Asp Val
 1               5                  10                  15      
Val Lys Val
            


<210> 4899
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4899
Trp Asn Gly Lys Asn Leu Thr Thr Asn Gln Phe Leu
 1               5                  10          


<210> 4900
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4900
Ser Ala Pro Pro Pro Ser Asn Ser Ser Ser Ser Ser Ala Pro Arg Arg
 1               5                  10                  15      


<210> 4901
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4901
Arg Val Leu Ser Ala Pro Pro His Phe His Phe Gly Gln Thr Asn Arg
 1               5                  10                  15      
Thr
    


<210> 4902
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4902
Arg Thr Phe Asn Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr
 1               5                  10                  15      
Lys Arg
        


<210> 4903
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4903
Arg Gln Leu Asn Tyr Thr Ile Gly Glu Val Pro Ile Ser Phe Val Asp
 1               5                  10                  15      
Arg Val
        


<210> 4904
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4904
Arg Lys Lys Thr Thr Pro Thr Pro Ser Thr Asn Ser Val Leu Ser Thr
 1               5                  10                  15      
Ser Thr Asn Arg Ser
            20      


<210> 4905
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4905
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly
 1               5                  10                  15      
Ile Leu Asn Val Ser Ala Val Asp Lys Ser
            20                  25      


<210> 4906
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4906
Met Val Asn Phe Thr Val Asp Gln Ile Arg Ala
 1               5                  10      


<210> 4907
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4907
Lys Val Ala Asn Val Ser Leu Leu Ala Leu Tyr Lys Gly
 1               5                  10              


<210> 4908
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4908
Lys Thr Val Thr Asn Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp
 1               5                  10                  15      
Ser Gln Arg Gln
            20  


<210> 4909
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4909
Lys Ser Glu Leu Gly Asn Gln Ser Pro Ser Thr Ser Ser Arg Gln
 1               5                  10                  15  


<210> 4910
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4910
Lys Asn Gln Val Ala Met Asn Pro Thr Asn Thr Val Phe Asp Ala Lys
 1               5                  10                  15      
Arg
    


<210> 4911
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4911
Lys Asn Leu Met Asn Val Ser Asn Ala Arg Arg Pro
 1               5                  10          


<210> 4912
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4912
Lys Met Ala Val Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu Leu
 1               5                  10                  15      
Phe Lys Arg
            


<210> 4913
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4913
Lys Gly Pro Pro Gln Ser Pro Val Phe Glu Gly Val Tyr Asn Asn Ser
 1               5                  10                  15      
Arg Met
        


<210> 4914
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4914
Lys Gly Ala Lys Ala Ala Asn Val Thr Gly Pro Gly Gly Val Pro Val
 1               5                  10                  15      
Gln Gly Ser Lys Tyr
            20      


<210> 4915
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4915
Lys Asp Leu Leu Ala Arg Asn Met Ser Arg Met Leu Lys Met
 1               5                  10                  


<210> 4916
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4916
Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro
 1               5                  10                  15      
Asn Ser Gly Arg Ile
            20      


<210> 4917
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4917
Arg Ser Glu Ala Val Thr Leu Asn Phe Thr Val Pro Thr Gly Ala Arg
 1               5                  10                  15      
Ser
    


<210> 4918
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4918
Arg Ala Ser Val Asp Val Phe Gly Asn Arg Thr
 1               5                  10      


<210> 4919
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4919
Lys Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu
 1               5                  10              


<210> 4920
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4920
His Leu Asn Asp Ser Gly Gln Leu Gly Leu Arg Met
 1               5                  10          


<210> 4921
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4921
His Leu Leu Thr Gly Asn Gly Thr Glu Val Pro Leu Ser Gly Pro Ile
 1               5                  10                  15      
His Leu Ser Leu Pro Val Pro Ser Glu Thr Arg Ala
            20                  25              


<210> 4922
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4922
Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly
 1               5                  10      


<210> 4923
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4923
Arg Val Asp Ile Ile Val Ala Asn Leu Thr Val Thr Asp Lys Asp
 1               5                  10                  15  


<210> 4924
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4924
Arg Ser Glu Asn Ala Ser Leu Val Leu Ser Ser Ser Asn Gln Lys Arg
 1               5                  10                  15      


<210> 4925
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4925
Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu
 1               5                  10                  15      
Ala His Thr
            


<210> 4926
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4926
Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly Thr Leu Lys Leu
 1               5                  10                  15      


<210> 4927
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4927
Arg Asn Ile Thr Leu Thr Trp Arg Gln
 1               5                  


<210> 4928
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4928
Arg Asn Ala Thr Thr Ala His Asn Pro Val Arg Lys Pro
 1               5                  10              


<210> 4929
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4929
Arg Glu Val Pro Val Gly Ile Pro Phe Phe Val Asn Val Thr His Asn
 1               5                  10                  15      
Gly Thr Tyr Gln
            20  


<210> 4930
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4930
Arg Glu Phe Val Val Met Phe Ser Val Val Asp Glu Asn Phe Ser Trp
 1               5                  10                  15      
Tyr Leu Glu Asp Asn Ile Lys Thr
            20                  


<210> 4931
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4931
Lys Val Thr Ile Asn Val Met Asp Val Asn Asp Asn Ser Pro Val Val
 1               5                  10                  15      
Ile Ser Pro Pro Ser Asn Thr Ser Phe Lys Leu
            20                  25          


<210> 4932
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4932
Lys Val Leu Glu Asn Ser Thr Lys Asn
 1               5                  


<210> 4933
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4933
Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr
 1               5                  10                  15  


<210> 4934
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4934
Lys Leu Ser Pro Ile His Ile Ala Leu Asn Phe Ser
 1               5                  10          


<210> 4935
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4935
Lys Ile Tyr Leu Arg Asn Glu Ser Glu Phe Arg Asp
 1               5                  10          


<210> 4936
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4936
Lys Ile Val Ala Ser Asp Ser Gly Lys Pro Ser Leu Asn Gln Thr Ala
 1               5                  10                  15      
Leu Val Arg Val
            20  


<210> 4937
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4937
Lys Ile Ala Asn Ile Ser Gly Asp Gly Gln Lys Trp
 1               5                  10          


<210> 4938
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4938
Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg Glu
 1               5                  10                  15      


<210> 4939
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4939
Lys Gly Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile
 1               5                  10                  15  


<210> 4940
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4940
Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn
 1               5                  10                  15      
Tyr Asn Pro Ser Leu Lys Ser
            20              


<210> 4941
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4941
Lys Glu Leu Leu Leu Asn Thr Ser Glu Val Thr Val Arg Phe
 1               5                  10                  


<210> 4942
<211> 36
<212> PRT
<213> Homo sapiens

<400> 4942
Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val Tyr
 1               5                  10                  15      
Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu Phe
            20                  25                  30          
Asp Ser Lys Gly
        35      


<210> 4943
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4943
Ile Pro Gly Ala Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu
 1               5                  10                  


<210> 4944
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4944
His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser Glu
 1               5                  10                  15      
Leu Ser Ser Pro Pro Arg Gln
            20              


<210> 4945
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4945
Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu
 1               5                  10                  15  


<210> 4946
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4946
Tyr Thr Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys Val
 1               5                  10                  15      


<210> 4947
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4947
Trp Thr Asp Asp Pro Ile Val Asn Gly Thr Gln Glu His Thr Lys Val
 1               5                  10                  15      


<210> 4948
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4948
Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg
 1               5                  10      


<210> 4949
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4949
Arg Ser Asn Phe Thr Leu Thr Ala Ala Arg His
 1               5                  10      


<210> 4950
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4950
Arg Asn Ala Ser Ala Val Val Leu Tyr Asn Glu Glu Arg Tyr
 1               5                  10                  


<210> 4951
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4951
Arg Leu Tyr Asn Ala Glu Gln Val Leu Ser Trp Glu Pro Val Ala Leu
 1               5                  10                  15      
Ser Asn Ser Thr Arg Pro
            20          


<210> 4952
<211> 13
<212> PRT
<213> Homo sapiens

<400> 4952
Arg Leu Ile Val Leu His Tyr Asn His Ser Gly Arg Leu
 1               5                  10              


<210> 4953
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4953
Arg Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val
 1               5                  10          


<210> 4954
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4954
Arg Phe Gln Leu Ser Asn Ser Gly Pro Asn Ser Thr Ile Lys Met
 1               5                  10                  15  


<210> 4955
<211> 27
<212> PRT
<213> Homo sapiens

<400> 4955
Arg Cys Thr Leu Gln Gln Asp Cys Thr Asn Ser Ser Gln Gln His Phe
 1               5                  10                  15      
Trp Thr Ser Ala Ser Glu Gly Pro Ser Arg Cys
            20                  25          


<210> 4956
<211> 35
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 5, 6, 7, 11, 15, 17, 23, 24, 25, 26, 27, 29, 30
<223> Xaa = Any Amino Acid

<400> 4956
Pro Gly His Thr Xaa Xaa Xaa Pro Leu Leu Xaa Pro Phe Thr Xaa Asn
 1               5                  10                  15      
Xaa Thr Ile Thr Asn Leu Xaa Xaa Xaa Xaa Xaa Met Xaa Xaa Pro Gly
            20                  25                  30          
Ser Arg Lys
        35  


<210> 4957
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4957
Asn Gly Cys Gly Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn
 1               5                  10                  15      
His Gly Arg Ile
            20  


<210> 4958
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4958
Met Val Glu Gln Tyr Ser Asn Tyr Ser Val Asn Gly Glu Pro Val Asn
 1               5                  10                  15      
Gly Arg His
            


<210> 4959
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4959
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser
 1               5                  10          


<210> 4960
<211> 12
<212> PRT
<213> Homo sapiens

<400> 4960
Lys Val Val Asn Ile Thr Met Val Ala Leu Lys Leu
 1               5                  10          


<210> 4961
<211> 11
<212> PRT
<213> Homo sapiens

<400> 4961
Lys Val Gln Glu His Tyr Asn Tyr Thr Lys Glu
 1               5                  10      


<210> 4962
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4962
Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala Pro Asp
 1               5                  10                  15      
Lys Thr
        


<210> 4963
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4963
Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn
 1               5                  10                  15      
Gly Thr Lys Leu
            20  


<210> 4964
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4964
Lys Leu Pro Asn Asp Ser Arg Val
 1               5              


<210> 4965
<211> 23
<212> PRT
<213> Homo sapiens

<400> 4965
Lys Leu Asn Val Asn Glu Asn Val Glu Cys Gly Asn Asn Thr Cys Thr
 1               5                  10                  15      
Asn Asn Glu Val His Asn Leu
            20              


<210> 4966
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4966
Lys Ile Asn Leu Asn Glu Ser Met Gln Val Val Ser Arg Arg
 1               5                  10                  


<210> 4967
<211> 29
<212> PRT
<213> Homo sapiens

<400> 4967
Lys Glu Thr Met Ser Val Ser Leu Asn Gln Thr Val Thr Gln Leu Gln
 1               5                  10                  15      
Gln Leu Leu Gln Ala Val Asn Gln Gln Leu Thr Lys Glu
            20                  25                  


<210> 4968
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4968
His Gly Phe Ser Asn Ala Thr Gln Ile Thr Ser Ser Lys Phe
 1               5                  10                  


<210> 4969
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4969
Phe Ser Leu Glu Ser His Asn Ile Ser Leu Thr Glu His Ser Ser Met
 1               5                  10                  15      
Pro Val Glu Lys Asn
            20      


<210> 4970
<211> 8
<212> PRT
<213> Homo sapiens

<400> 4970
Asp Tyr Tyr Asn Leu Thr Lys Phe
 1               5              


<210> 4971
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4971
Cys Asp Thr Pro Ala Asn Cys Thr Tyr Leu Asp Leu Leu Gly Thr Trp
 1               5                  10                  15      
Val Phe Gln Val Gly Ser Ser Gly Ser Gln Arg Asp
            20                  25              


<210> 4972
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4972
Arg Leu Pro Asn Ser Thr Ile Tyr Val Val Glu Pro Gly Tyr Leu Gly
 1               5                  10                  15      
Phe Thr Val His Pro Gly Asp Arg Trp
            20                  25  


<210> 4973
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4973
Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu Ser Ala
 1               5                  10                  15      
Pro Val Leu Arg Thr
            20      


<210> 4974
<211> 17
<212> PRT
<213> Homo sapiens

<400> 4974
Lys Ala Ile Asn Gln Thr Ala Val Glu Cys Thr Trp Thr Gly Pro Arg
 1               5                  10                  15      
Asn
    


<210> 4975
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4975
Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asn Asp Ser Gly Glu Tyr
 1               5                  10                  15      
Arg Cys
        


<210> 4976
<211> 32
<212> PRT
<213> Homo sapiens

<400> 4976
Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu Tyr Gly Tyr
 1               5                  10                  15      
Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro Pro Arg Ile
            20                  25                  30          


<210> 4977
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4977
Asp Gly Pro Ser Gly Leu Val Thr Ala Asn Ile Thr Asp Ser Glu Ala
 1               5                  10                  15      
Leu Ala Arg Trp
            20  


<210> 4978
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4978
Arg Leu Ala Asn Arg Thr Gly Gly Leu Glu Val Leu Leu Asn Gln Glu
 1               5                  10                  15      
Val Leu Ser Phe Thr Glu Gln Ser Trp Met Asp Leu Lys Gly
            20                  25                  30  


<210> 4979
<211> 34
<212> PRT
<213> Homo sapiens

<400> 4979
Arg Ser Cys Gly Met Gly Ser Ile Thr Thr Val Thr Val Asn Gln Ser
 1               5                  10                  15      
Leu Leu Ser Pro Leu Asn Leu Glu Val Asp Pro Asn Ile Gln Ala Met
            20                  25                  30          
Arg Thr
        


<210> 4980
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4980
Arg Asn Thr Thr Thr Gly Ala Ser Ala Ala Ala Val Ala Ser Leu Val
 1               5                  10                  15      
Ser Gly Pro Leu Ser His Ser Ala
            20                  


<210> 4981
<211> 35
<212> PRT
<213> Homo sapiens

<400> 4981
Arg Asp Met Asn Leu Thr Gly Cys Leu Glu Ser Gly Gly Ser Glu Glu
 1               5                  10                  15      
Pro Gly Gly Ile Gly Val Gly Glu Lys Asp Trp Thr Ser Asp Val Asn
            20                  25                  30          
Val Lys Ser
        35  


<210> 4982
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4982
Met Gly Gly Met Glu Pro His His Met Asn Gly Ser Leu Gly Ser Gly
 1               5                  10                  15      
Asp Ile Asp Gly Leu Pro Lys Asn
            20                  


<210> 4983
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4983
Met Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Lys Glu Thr Gly Asp
 1               5                  10                  15      
Arg Asn Tyr Ala Ile Gly Tyr Tyr His Glu Glu Lys Lys Cys
            20                  25                  30  


<210> 4984
<211> 30
<212> PRT
<213> Homo sapiens

<400> 4984
Lys Gly His Gly Pro Gly Gly Gln Ala Thr Asn Lys Thr Ser Asn Cys
 1               5                  10                  15      
Val Val Leu Lys His Ile Pro Ser Gly Ile Val Val Lys Val
            20                  25                  30  


<210> 4985
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4985
Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala Lys
 1               5                  10                  15      
His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val
            20                  25              


<210> 4986
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4986
Lys Glu Asn Leu Ser Ser Ser Glu His Thr Gln Phe Asn Ser Arg Ser
 1               5                  10                  15      


<210> 4987
<211> 39
<212> PRT
<213> Homo sapiens

<400> 4987
Phe Pro Arg Leu Cys Pro Val Tyr Ser Asn Leu Leu Gly Gly Gly Ser
 1               5                  10                  15      
Leu Pro His Pro Met Leu Asn Pro Thr Ser Leu Pro Ser Ser Leu Pro
            20                  25                  30          
Ser Asp Gly Ala Arg Arg Leu
        35                  


<210> 4988
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4988
Glu Asn Ser Thr Asp Asn Pro Asp Leu Trp Phe Leu His Asp Gln Asn
 1               5                  10                  15      
Ser Ser Ala Phe Lys Phe Tyr Arg Lys Lys
            20                  25      


<210> 4989
<211> 35
<212> PRT
<213> Homo sapiens

<400> 4989
Cys Met Thr Val Val Gln Asn Leu Met Glu Arg Asn Asn Leu Ser Tyr
 1               5                  10                  15      
Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr Ile Ile Asp Lys
            20                  25                  30          
Ser Lys Ser
        35  


<210> 4990
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4990
Met Lys Asp Leu His Ser Asp Asp Asn Glu Glu Glu Ser Asp Glu Val
 1               5                  10                  15      
Glu Asp Asn Asp Asn Asp Ser Glu Met Glu Arg Pro
            20                  25              


<210> 4991
<211> 25
<212> PRT
<213> Homo sapiens

<400> 4991
Arg Leu Tyr Gly Asp Ile Leu Gln Trp Gly Phe Leu Asp Thr Phe Phe
 1               5                  10                  15      
Asn Leu Thr Leu Lys Glu Ile His Phe
            20                  25  


<210> 4992
<211> 20
<212> PRT
<213> Homo sapiens

<400> 4992
Lys Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr
 1               5                  10                  15      
Phe Pro Val Trp
            20  


<210> 4993
<211> 19
<212> PRT
<213> Homo sapiens

<400> 4993
Gly Ile Ile Ala Val Ala Asn Asp Thr Asn Ser Cys Glu Leu Ser Pro
 1               5                  10                  15      
Cys Arg Ile
            


<210> 4994
<211> 24
<212> PRT
<213> Homo sapiens

<400> 4994
Arg Gly Ile Ser Asp Asn Tyr Thr Leu Ala Leu Ile Thr Tyr Ala Leu
 1               5                  10                  15      
Ser Ser Val Gly Ser Pro Lys Ala
            20                  


<210> 4995
<211> 34
<212> PRT
<213> Homo sapiens

<400> 4995
Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp
 1               5                  10                  15      
Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser
            20                  25                  30          
Val Ser
        


<210> 4996
<211> 22
<212> PRT
<213> Homo sapiens

<400> 4996
Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala Ser Asn
 1               5                  10                  15      
Lys Glu Glu Leu Arg Gly
            20          


<210> 4997
<211> 26
<212> PRT
<213> Homo sapiens

<400> 4997
Lys Gly Ser Ala Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly
 1               5                  10                  15      
Thr Leu Glu Ile Pro Val Ala Gln Lys Asp
            20                  25      


<210> 4998
<211> 18
<212> PRT
<213> Homo sapiens

<400> 4998
Val Ala Leu Asp Glu Ala Leu Asp Asn Tyr Thr Ile Thr Phe Leu Ile
 1               5                  10                  15      
Arg Gly
        


<210> 4999
<211> 28
<212> PRT
<213> Homo sapiens

<400> 4999
Arg Leu His Asn Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Leu Val
 1               5                  10                  15      
Asp Ile Phe Phe Ser Ser Val Thr Ile Pro Lys Met
            20                  25              


<210> 5000
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5000
Arg Ile Glu Thr Val Leu Pro Ala Glu Phe Phe Glu Val Leu Ser Ser
 1               5                  10                  15      
Ser Gln Asn Gly Ser Tyr His Arg Ile
            20                  25  


<210> 5001
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5001
Arg Gly Asp Pro Ser Val Ile Ser Val Asn Gly Thr Asp Phe Thr Phe
 1               5                  10                  15      
Arg Ser
        


<210> 5002
<211> 34
<212> PRT
<213> Homo sapiens

<400> 5002
Lys Leu Leu Thr Ser His Gly Met Gly Ile Gln Val Pro Leu Asn Ala
 1               5                  10                  15      
Thr Glu Phe Asn Tyr Leu Cys Pro Ala Ile Ile Asn Gln Ile Asp Ala
            20                  25                  30          
Arg Ser
        


<210> 5003
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5003
Lys Glu Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala
 1               5                  10                  15      
Gly Glu Tyr Thr Cys
            20      


<210> 5004
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5004
Val Met Met Asn Ser Ser Asn Ile Gln Val Lys Gln
 1               5                  10          


<210> 5005
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5005
Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val Ser
 1               5                  10                  


<210> 5006
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5006
Lys Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys
 1               5                  10                  


<210> 5007
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5007
Arg Gly Pro Pro Gly Val Asn Gly Thr Gln Gly Phe Gln Gly Cys Pro
 1               5                  10                  15      
Gly Gln Arg Gly
            20  


<210> 5008
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5008
Lys Ile Thr Asp Ile Glu Asn Gly Ser Leu Ala Asn Ile Pro Arg Val
 1               5                  10                  15      


<210> 5009
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5009
Lys Ala Tyr Ile Asn Asn Ser Leu Ile Leu Ser Glu Asp Ile Asp Pro
 1               5                  10                  15      
His Lys
        


<210> 5010
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5010
Gln Val Phe Gly Asp Asn Glu Ser Gln Ala Thr Ile Arg Val Lys Cys
 1               5                  10                  15      


<210> 5011
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5011
Leu Phe Tyr Pro Tyr Asn Asn Thr Ala Asp Gly Val Tyr Lys Val
 1               5                  10                  15  


<210> 5012
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5012
Lys Tyr Pro Val Gly Asn Asn Gln Thr Ala Val Gln Asp Asn Val Lys
 1               5                  10                  15      
Val
    


<210> 5013
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5013
Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser Cys
 1               5                  10                  


<210> 5014
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5014
Lys Ala Leu Ser Pro Asn Ser Thr Ile Ser Ser Ala Pro Lys Asp
 1               5                  10                  15  


<210> 5015
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5015
Lys Val Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser Leu Arg Ala
 1               5                  10                  15      


<210> 5016
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5016
Lys Ser Asn Asn Ser Glu Ser Pro His Pro Ser Pro Phe Ser Arg Phe
 1               5                  10                  15      


<210> 5017
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5017
Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala
 1               5                  10                  15  


<210> 5018
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5018
Lys Ala Val Ser Ser Phe Asp Pro Glu Ile Asp Leu Ser Asn Gln Ser
 1               5                  10                  15      
Gly Arg Val
            


<210> 5019
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5019
Tyr Leu Ala Ser Gly Asn Val Ser Gly Gly Val Cys Asp Gly Cys Gln
 1               5                  10                  15      
His Asn Thr Ala Gly Arg His
            20              


<210> 5020
<211> 10
<212> PRT
<213> Homo sapiens

<400> 5020
Tyr Leu His Ser Asn Asn Ile Thr Lys Val
 1               5                  10  


<210> 5021
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5021
Lys Phe Asn Arg Glu Asn Ser Ser Asn Ile Leu Asp Asn Leu Leu
 1               5                  10                  15  


<210> 5022
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5022
Lys Glu Asn Met Val Leu Asn Leu Ser Cys Glu Ala Ser Gly His Pro
 1               5                  10                  15      
Arg Pro
        


<210> 5023
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5023
Ile Asp Ser Ser Glu Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys
 1               5                  10                  15      
Asn
    


<210> 5024
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5024
Met Ile Thr Leu Lys Val Asp Asn Leu Thr Tyr Arg Thr
 1               5                  10              


<210> 5025
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5025
Arg Leu Val Gln Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn
 1               5                  10                  


<210> 5026
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5026
Arg Lys Leu Ile His Val Asn Cys Ser Asn Leu Pro
 1               5                  10          


<210> 5027
<211> 10
<212> PRT
<213> Homo sapiens

<400> 5027
Lys Val His Asn Glu Ser Ile Leu Asp Gln
 1               5                  10  


<210> 5028
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5028
Arg Phe Gly Thr Cys Ser Gln Leu Cys Asn Asn Thr Lys Gly
 1               5                  10                  


<210> 5029
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5029
Lys Val Val Asn Glu Met Cys Pro Asn Ile Thr Arg Ile
 1               5                  10              


<210> 5030
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5030
Tyr Glu Glu Leu Val Asp Val Asn Cys Ser Ala Val Leu Arg Phe
 1               5                  10                  15  


<210> 5031
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5031
Arg Val Gln Asn Val Thr Glu Phe Asp Asp Ser Leu Leu Arg Asn
 1               5                  10                  15  


<210> 5032
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5032
Leu Gly Ala His Asn Ile Thr Glu Glu Glu Asp Thr Trp Gln Lys Leu
 1               5                  10                  15      


<210> 5033
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5033
Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser
 1               5                  10                  15      


<210> 5034
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5034
Arg Phe Ser Ala Asp Leu Gly Tyr Asn Gly Thr Arg Gln
 1               5                  10              


<210> 5035
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5035
Arg Trp Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg
 1               5                  10                  15      
Cys
    


<210> 5036
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5036
Lys Leu Phe Gln Asn Cys Ser Glu Leu Phe Lys Thr
 1               5                  10          


<210> 5037
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5037
Ser Asn Gly Ser Ile Phe Leu Asp Ile Leu Arg Ser
 1               5                  10          


<210> 5038
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5038
Arg Lys Arg Ser Asp Ser Ser Gly Gly Tyr Asn Leu Ser Asp Ile Ile
 1               5                  10                  15      
Gln Ser Pro
            


<210> 5039
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5039
Arg Phe Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala
 1               5                  10                  15  


<210> 5040
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5040
Gln Arg Asp Glu Thr Gly Asn Asn Ser Val Gln Thr Val Phe Gln Gly
 1               5                  10                  15      
Thr Leu Ala Ala Thr Lys Arg
            20              


<210> 5041
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5041
Lys Asp Ser Ser Gly Pro Ala Asn Ser Thr Ala Asp Leu Leu Lys Gln
 1               5                  10                  15      


<210> 5042
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5042
Glu Ser Asn Leu Thr Ser Thr Leu Ser Gly Gly Gly Gly Gly Ala Thr
 1               5                  10                  15      
Ala Asp Ser Met Gly Gly Lys Glu
            20                  


<210> 5043
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5043
Val Arg Asn Asp Thr Pro Cys Gly Thr Thr Ile Gly Pro Ile Leu Ala
 1               5                  10                  15      
Ser Arg Leu Gly Leu Arg Val
            20              


<210> 5044
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5044
Ile Tyr Leu Ala Asn Tyr Thr Leu Pro Asp Ser Pro Phe Leu Lys Ile
 1               5                  10                  15      


<210> 5045
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5045
Tyr Val Gly Ala Asp Cys Gly Tyr Pro Ala Cys Pro Glu Asn Cys Ser
 1               5                  10                  15      
Gly His Gly Glu Cys Val Arg Gly
            20                  


<210> 5046
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5046
Tyr Asn Ile Gly Asn Tyr Thr Gln Ala Val Glu Cys Ala Lys Thr
 1               5                  10                  15  


<210> 5047
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5047
Trp Gly Thr Phe Glu Glu Val Ser Gly Asn Val Ser Pro Gly Thr Arg
 1               5                  10                  15      
Arg
    


<210> 5048
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5048
Arg Val Asn Asp Asn Lys Thr Ala Ala Glu Glu Ala Leu Arg Lys
 1               5                  10                  15  


<210> 5049
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5049
Arg Ser Leu Glu Ala Gln Gly Asn Ser Ser His Leu Asp Ala Asp Thr
 1               5                  10                  15      
Val Arg His
            


<210> 5050
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5050
Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp
 1               5                  10                  


<210> 5051
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5051
Leu Thr Val Glu Thr Leu Glu His Asn Gln Thr Tyr Glu Cys Arg Ala
 1               5                  10                  15      


<210> 5052
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5052
His Ala Asp Leu Met Ser Asn Leu Ser Gln Asp Glu Leu Ala Arg Ile
 1               5                  10                  15      


<210> 5053
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5053
Arg Gln Glu Cys Tyr Ala Phe Asn Gly Thr Gln Arg Phe
 1               5                  10              


<210> 5054
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5054
Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp
 1               5                  10          


<210> 5055
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5055
Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp Leu Arg Ile
 1               5                  10                  


<210> 5056
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5056
Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His
 1               5                  10              


<210> 5057
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5057
Lys Leu Ser Asp Thr Thr Ser Gln Ser Asn Ser Thr Ala Lys Glu
 1               5                  10                  15  


<210> 5058
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5058
Lys Thr Phe Lys Asn Glu Ser Glu Asn Thr Cys Gln Asp Val Asp Glu
 1               5                  10                  15      
Cys Ser Ser Gly Gln His Gln Cys
            20                  


<210> 5059
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5059
Lys Asn Tyr Ser Val Asn Leu Glu Asn Leu Lys Asn
 1               5                  10          


<210> 5060
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5060
Phe Asp Val Leu Ile His Asp Pro Ser His Phe Leu Asn Tyr Ser Thr
 1               5                  10                  15      
Ile Asn Tyr Lys Trp
            20      


<210> 5061
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5061
Arg Ser Asp Glu Tyr Asn Cys Ser Ser Gly Met Cys Ile Arg Ser
 1               5                  10                  15  


<210> 5062
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5062
Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val
 1               5                  10                  15  


<210> 5063
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5063
Arg Trp Cys Pro Gln Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg
 1               5                  10                  15      
Cys
    


<210> 5064
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5064
Thr Ala Gln Val Gln Pro Leu Gln Asn Met Thr Gly Phe Pro Ala Leu
 1               5                  10                  15      
Ala Gly Pro Pro Ala His Ser Gln Leu Arg Ala
            20                  25          


<210> 5065
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5065
Arg Ser Ser Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr
 1               5                  10                  15      
Gly Lys Arg
            


<210> 5066
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5066
Arg Gln Ala Cys Ser Ser Ala Ser Asp Gly Asn Ile Ser Asn Arg Ser
 1               5                  10                  15      
Lys
    


<210> 5067
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5067
Arg Asn Gly Ser Pro Pro Pro Gly Ala Pro Ser Ser Arg Phe
 1               5                  10                  


<210> 5068
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5068
Arg Leu Asn Val Lys Asn Glu Glu Leu Asp Ala Met Met Lys Glu Ala
 1               5                  10                  15      
Ser Gly Pro Ile Asn Phe Thr Val Phe Leu
            20                  25      


<210> 5069
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5069
Arg Leu Glu Ala Asn Gln Thr Leu Glu Gly Ala Gly Gly Ser Ile Thr
 1               5                  10                  15      
Ser Val Asp Phe
            20  


<210> 5070
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5070
Arg Lys Gln Gln His Asn Leu Ser Ala Phe Pro Lys Glu
 1               5                  10              


<210> 5071
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5071
Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val Leu Lys Val
 1               5                  10                  15  


<210> 5072
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5072
Gln Ile Leu Phe Pro Lys Val Asn Leu Ser Pro Val Thr Pro Ala Lys
 1               5                  10                  15      
Asp Thr Gly Leu Thr Ala Ala Pro Gln Glu Pro Lys Ala
            20                  25                  


<210> 5073
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5073
Pro Glu Ala Asn Ser Ser Trp Met Asp Thr Val Ile Arg Gln
 1               5                  10                  


<210> 5074
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5074
Asn Arg Pro Leu Glu Asn Asp Ser Phe Leu Gln Val Thr Leu Gln Asp
 1               5                  10                  15      
Met Gly Ser Gln Lys Lys
            20          


<210> 5075
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5075
Lys Val Asp Ser Leu Asn Leu Gln Asn Ser Ser Gln Leu Asp
 1               5                  10                  


<210> 5076
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5076
Lys Gln Thr Cys Glu Asn Pro Asp Phe Glu Asn Gly Ser Glu Lys Thr
 1               5                  10                  15      


<210> 5077
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5077
Lys Asn Thr Ser Phe Ala Tyr Pro Ala Ile Arg Tyr
 1               5                  10          


<210> 5078
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5078
Lys Asn Ser Ser Ser Pro Val Ala Ala Thr Pro Ala Ser Val Asn Thr
 1               5                  10                  15      


<210> 5079
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5079
Lys Glu Glu Phe Gly Leu Thr Ser Leu Gly Asn Thr Ser Phe Thr Asp
 1               5                  10                  15      
Phe Ser Cys Lys His Pro Arg Glu Leu
            20                  25  


<210> 5080
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5080
Lys Cys Ser Leu Tyr Ala Asp Ser Asp Gly Glu Asn Asp Ser Thr Ser
 1               5                  10                  15      
Asp Ser Glu Ser Ser Ser Ser Ser
            20                  


<210> 5081
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5081
Lys Cys Gly Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Thr Leu Ile
 1               5                  10                  15      
Thr His Lys
            


<210> 5082
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5082
Ile Ser Arg Ile Lys Thr Ser Gln Ala Asp Phe Asn Lys Thr Glu Leu
 1               5                  10                  15      
Glu Arg Tyr Lys Glu
            20      


<210> 5083
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5083
His Val Asn Phe Glu Asp Asn Asp Asn Arg Ser
 1               5                  10      


<210> 5084
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5084
Glu Val Ile Ala Ser Thr Asn Cys Asn Leu Thr Met Ser Leu Leu Lys
 1               5                  10                  15      
Leu
    


<210> 5085
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5085
Glu Lys Asn Val Ser Glu Gln Met Thr Asn Glu Asp Lys Ser
 1               5                  10                  


<210> 5086
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5086
Met Gln Val Tyr Asn Leu Thr Phe Tyr Ser Thr Ser Asp Gly Lys Glu
 1               5                  10                  15      


<210> 5087
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5087
Arg Asn Asn Thr Gly Gly Ser Thr Gly Leu Pro Arg Arg Lys
 1               5                  10                  


<210> 5088
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5088
Arg Glu Gln Gln Asp Glu His Ile Leu Glu Val Thr Val Thr Asp Asn
 1               5                  10                  15      
Gly Ser Pro Pro Lys Ser
            20          


<210> 5089
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5089
Pro Lys Ser Ala Leu Asn Ala Ser Asp Asn Leu Lys Asn
 1               5                  10              


<210> 5090
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5090
Leu Ser Glu Lys Asn Thr Thr Ala Glu Cys Trp Asp Glu Lys Phe
 1               5                  10                  15  


<210> 5091
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5091
Lys Arg Ala Asn Glu Met Asn Ile Ser Pro Ala Ser Leu Ala Ser Leu
 1               5                  10                  15      
Tyr Glu
        


<210> 5092
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5092
Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly Asn Cys His Leu
 1               5                  10                  15      
Arg Gly
        


<210> 5093
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5093
Lys Glu Asn Ala Thr Ile Val Val Gly Gly Leu Glu Asp Ala Ala Ala
 1               5                  10                  15      
Val Asp Phe
            


<210> 5094
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5094
Tyr Thr Phe His Ala Asn Gly Ser Leu Thr Ile Asn Lys Val Lys Leu
 1               5                  10                  15      


<210> 5095
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5095
Arg Pro Gly Ala Ala Ser Asn Leu Ser Tyr Arg Ala
 1               5                  10          


<210> 5096
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5096
Arg Asn Ala Leu Gly Gln Val Glu Ala Pro Ala Ser Leu Thr Val Leu
 1               5                  10                  15      
Thr Pro Asp Gln Leu Asn Ser Thr
            20                  


<210> 5097
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5097
Arg Asn Lys Ser Phe Ser Leu Asp His Met Asn Ile Tyr Asp
 1               5                  10                  


<210> 5098
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5098
Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser Asp Glu Asp Phe Leu Leu
 1               5                  10                  15      
Leu Glu Leu Leu His
            20      


<210> 5099
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5099
Arg Ile Tyr Pro Leu Thr Trp Asn Gly Ser Leu Cys Met Arg Leu
 1               5                  10                  15  


<210> 5100
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5100
Arg Asp Cys Ser Ala Asn Thr Thr Ser Cys His Ile
 1               5                  10          


<210> 5101
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5101
Arg Ala Glu Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys
 1               5                  10                  


<210> 5102
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5102
Pro Thr Leu Asn Gly Ser Glu Asn Trp Gly Ser Pro Val Ser Thr Gln
 1               5                  10                  15      
Glu Glu Gly Pro Asp Thr Gly Trp Glu Arg Glu
            20                  25          


<210> 5103
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5103
Leu Ser Leu Glu Asn Asn Ser Ile Ser Ser Ile Pro Glu Lys Tyr
 1               5                  10                  15  


<210> 5104
<211> 10
<212> PRT
<213> Homo sapiens

<400> 5104
Lys Gln Asn Leu Thr Val Thr Asp Arg Val
 1               5                  10  


<210> 5105
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5105
Lys Met Tyr Gln Met Phe Asn Glu Thr Thr Ser Gln Val Arg Lys
 1               5                  10                  15  


<210> 5106
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5106
Lys Ile Val Gly Pro Glu Glu Asn Leu Ser Gln Ala Glu Ala Arg Asn
 1               5                  10                  15      
Met Gly
        


<210> 5107
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5107
Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln Leu Ser
 1               5                  10                  15      
Lys Gly
        


<210> 5108
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5108
Lys Glu Thr Ile Gly Asp Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys
 1               5                  10                  15      
Val His Leu
            


<210> 5109
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5109
His Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn
 1               5                  10                  


<210> 5110
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5110
His Leu Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val
 1               5                  10                  15  


<210> 5111
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5111
Phe Gly Ala Val Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala
 1               5                  10                  15      
Cys Asn Lys Leu
            20  


<210> 5112
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5112
Ala Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile
 1               5                  10                  15      


<210> 5113
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5113
Ala His Leu Tyr Tyr Asn Val Thr Glu Lys Val
 1               5                  10      


<210> 5114
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5114
Val Leu Phe Thr Ile Asn Cys Thr Ile Thr Asn Leu Gln Tyr Glu Glu
 1               5                  10                  15      
Asp Met Arg Arg Thr
            20      


<210> 5115
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5115
Ser Lys Cys Gly Ile Asn Phe Ser Ser Leu Arg Lys
 1               5                  10          


<210> 5116
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5116
Arg Ile Thr Ser Asn Ala Thr Ser Asp Leu Asn Ile Lys Val
 1               5                  10                  


<210> 5117
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5117
Leu Glu Val Asp Asn His Thr Val Thr Thr Arg Phe
 1               5                  10          


<210> 5118
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5118
Lys Thr Asn Glu Gln Val Val Glu Val Cys Thr Asn Thr Ser Ser Pro
 1               5                  10                  15      
His Ala
        


<210> 5119
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5119
Lys Gln Leu Glu Lys Ile Glu Ser Gly Glu Met Gly Leu Asn Lys Val
 1               5                  10                  15      
Trp Ile Asn Ile Thr Glu
            20          


<210> 5120
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5120
Lys Phe Ser Ile Met Asn Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro
 1               5                  10                  15      


<210> 5121
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5121
Phe Asn Lys Ser Ala Asn Ile Met Leu Asp Lys Trp
 1               5                  10          


<210> 5122
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5122
Met Ser Leu Asn Asn Ser Ser Asn Val Phe Leu Asp Ser Val Pro Ser
 1               5                  10                  15      


<210> 5123
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5123
Arg Lys Asn Leu Thr Leu Met Ala Thr Thr Ser Gln Leu Pro Lys Leu
 1               5                  10                  15      


<210> 5124
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5124
Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val
 1               5                  10                  15      
Leu Ser Thr Lys Gln
            20      


<210> 5125
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5125
Arg Met Ser Val Ile Asn Phe Glu Cys Asn Lys Thr Ala Gly Asn Asp
 1               5                  10                  15      
Gly Lys Gly
            


<210> 5126
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5126
Arg Met Asp Gly Cys Thr Leu Thr Asp Glu Gln Leu Leu Tyr Ser Phe
 1               5                  10                  15      
Asn Leu Ser Ser Leu Ser Thr Ser Thr Phe Lys Val
            20                  25              


<210> 5127
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5127
Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys
 1               5                  10                  15      
Val Ala Lys Ser
            20  


<210> 5128
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5128
Arg Gly Asn Val Ile Ser Ser His Gly Asn Pro Ile Leu Leu Asn Ser
 1               5                  10                  15      
Ser Ile Pro Glu Asp Pro Ser Ile Lys Ala
            20                  25      


<210> 5129
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5129
Val Phe Gln Pro Leu Ala Asn Leu Ser Asn Leu Asp Leu Thr Ala Asn
 1               5                  10                  15      
Arg Leu
        


<210> 5130
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5130
Lys Asn Ala Thr Tyr Gly Tyr Val Leu Asp Asp Pro Asp Pro Asp Asp
 1               5                  10                  15      
Gly Phe Asn Tyr Lys Gln
            20          


<210> 5131
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5131
Arg Ala Leu Glu Ser Ser Ala Pro Asn Leu Gln Leu Glu Thr Ser Asp
 1               5                  10                  15      
Val Leu Ala Asn Val Thr Tyr Leu Lys Gly
            20                  25      


<210> 5132
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5132
Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly Val Lys
 1               5                  10                  15      
Ser
    


<210> 5133
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5133
Lys Leu His Val Thr Leu Tyr Asn Cys Ser Phe Gly Arg Ser
 1               5                  10                  


<210> 5134
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5134
Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly Ile
 1               5                  10                  15      
Cys
    


<210> 5135
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5135
Ser Ser Ala Thr Thr Ser Thr Thr Thr Ser Thr Gly Ser Gly Ser Gly
 1               5                  10                  15      
Asn Ser Ser Ser Asn Ala Thr Gly Asn Thr Val Ala Ala
            20                  25                  


<210> 5136
<211> 31
<212> PRT
<213> Homo sapiens

<400> 5136
Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly Tyr Ile Ile Pro
 1               5                  10                  15      
Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly Glu Arg Arg
            20                  25                  30      


<210> 5137
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5137
Lys Val Val Phe Leu Ser Pro Ala Val Pro Glu Glu Pro Glu Ala Tyr
 1               5                  10                  15      
Asn Leu Thr Val Leu Ile Glu Met Asp Gly His Arg Ala
            20                  25                  


<210> 5138
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5138
Arg Thr Leu Thr Leu Val Glu Asn Lys Pro Ile Gln Leu Asn Cys Ser
 1               5                  10                  15      
Val Lys Ser
            


<210> 5139
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5139
Asn Met Glu Leu Asp Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr
 1               5                  10                  15      
Ser Ser Lys Trp
            20  


<210> 5140
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5140
Lys Met Gly His Asn Tyr Thr Phe Thr Val Gln Ala Arg Cys
 1               5                  10                  


<210> 5141
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5141
Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala
 1               5                  10                  15      
Ser Ser Glu Thr Leu Arg Cys
            20              


<210> 5142
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5142
Val Lys Asn Thr Ser Asn Glu Ala Phe Phe Lys Arg Lys Cys
 1               5                  10                  


<210> 5143
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5143
Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Cys
 1               5                  10                  15      
Ser Gln Cys Phe Ile Cys Thr Ala Lys Thr
            20                  25      


<210> 5144
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5144
Arg Ile Ser Val Ala Gly Arg Asn Cys Ser Phe Gln Pro Glu Arg Tyr
 1               5                  10                  15      


<210> 5145
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5145
Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro Ala Ser Asp
 1               5                  10                  15      
Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His
            20                  25          


<210> 5146
<211> 30
<212> PRT
<213> Homo sapiens

<400> 5146
Lys Gln Glu Glu Ala Gly Val Arg Pro Ser Ala Gly Asn Val Ser Thr
 1               5                  10                  15      
His Pro Ser Leu Ser Gln Arg Pro Gly Gly Ser Thr Lys Ser
            20                  25                  30  


<210> 5147
<211> 35
<212> PRT
<213> Homo sapiens

<400> 5147
Arg Ala Cys His Cys Pro Asp Ala Gly Gly Glu Leu Ile Cys Tyr Gln
 1               5                  10                  15      
Leu Pro Gly Cys His Gly Asn Phe Ser Asp Ala Glu Glu Gly Asp Pro
            20                  25                  30          
Glu Arg His
        35  


<210> 5148
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5148
Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala Lys Ser
 1               5                  10                  15  


<210> 5149
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5149
Arg Val Gly Tyr Gln Ser Gln Asn Ile Ser Cys Phe Phe Arg Leu
 1               5                  10                  15  


<210> 5150
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5150
Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu
 1               5                  10                  15      
Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe
            20                  25          


<210> 5151
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5151
Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys
 1               5                  10                  15      
Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly
            20                  25                  


<210> 5152
<211> 32
<212> PRT
<213> Homo sapiens

<400> 5152
Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe
 1               5                  10                  15      
Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe
            20                  25                  30          


<210> 5153
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5153
Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val Met
 1               5                  10                  15      
Tyr Phe Leu Thr Ala
            20      


<210> 5154
<211> 35
<212> PRT
<213> Homo sapiens

<400> 5154
Lys Ile Ser Val Asp Val Gln Arg Pro Thr Gly Ser Phe Ser Ile Asp
 1               5                  10                  15      
Phe Leu Gly Gly Phe Thr Ser Tyr Tyr Asp Asn Ile Thr Asn Val Val
            20                  25                  30          
Val Lys Leu
        35  


<210> 5155
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5155
Arg Lys Ser Gln Gly Asn Val Ile Asn Ile Ser Ser Leu Val Gly Ala
 1               5                  10                  15      
Ile Gly Gln Ala Gln Ala Val
            20              


<210> 5156
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5156
Arg Ile Gly Val Arg Asp Val Arg Leu Asn Gly Ser Ala Ala Ser His
 1               5                  10                  15      
Val Leu His Gln Asp Ser Gly
            20              


<210> 5157
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5157
Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe
 1               5                  10                  15      
Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu
            20                  25              


<210> 5158
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5158
Leu Val Ser Ala Val Ser Asn Ser Ser Gln Gly Thr Thr Ala Ala Ala
 1               5                  10                  15      
Gly Pro Glu Glu Lys Phe
            20          


<210> 5159
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5159
Leu Pro Arg Pro Ser Glu Val Asn Glu Thr Ile Leu Arg Pro
 1               5                  10                  


<210> 5160
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5160
Leu Met Lys Lys Leu Asp Ile Leu Gly Asp Asn Ala Asn Leu Thr Asn
 1               5                  10                  15      
Glu Glu Gln Val
            20  


<210> 5161
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5161
Leu Leu Tyr Gly Gly Asp Cys Ser His Trp Thr Glu Ser Ile Asn Leu
 1               5                  10                  15      
Thr Asn Asn Phe Lys
            20      


<210> 5162
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5162
Lys Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser
 1               5                  10                  15      
Cys Ser Ser Glu Cys Ile His Lys Leu
            20                  25  


<210> 5163
<211> 34
<212> PRT
<213> Homo sapiens

<400> 5163
Lys Val Gly Gly Thr Lys Pro Ala Gly Gly Asp Phe Gly Glu Val Leu
 1               5                  10                  15      
Asn Ser Ala Ala Asn Ala Ser Ala Thr Thr Thr Glu Pro Leu Pro Glu
            20                  25                  30          
Lys Thr
        


<210> 5164
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5164
Lys Thr Glu Ala Leu Leu Glu Ala Lys Thr Asn Glu Leu Ile Asn Ile
 1               5                  10                  15      
Ser Ser Ser Lys Thr
            20      


<210> 5165
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5165
Lys His Ser Asn Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp
 1               5                  10                  


<210> 5166
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5166
Lys His Phe Met Gln Asn Phe Ala Cys Ser Asn Val Ser Gln Val Gln
 1               5                  10                  15      
Leu Ile Thr Ser Lys Gly
            20          


<210> 5167
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5167
Lys Glu Phe His Pro Thr Phe Asp Pro Leu Ile Asn Asn Thr Trp Leu
 1               5                  10                  15      
Ser Arg Ser
            


<210> 5168
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5168
Lys Ala Phe Asn Asn Ser Ser Ile Leu Ala Lys His
 1               5                  10          


<210> 5169
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5169
Ala Pro Gly Glu Thr Pro Ala Ala Ile Ala Asn Ser Ser Gly Gln Pro
 1               5                  10                  15      
Tyr Gln Pro Leu Arg Glu
            20          


<210> 5170
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5170
Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe Ser Pro
 1               5                  10                  15      
Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser
            20                  25                  


<210> 5171
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5171
Met Val Asn Gln Ser Leu Leu Ser Pro Leu Asn Leu Glu Val Asp Pro
 1               5                  10                  15      
Asn Ile Gln Ala Val Cys
            20          


<210> 5172
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5172
Lys Thr Asp Pro Ala Asn Gln Phe Glu Trp Leu Glu Ser Thr Leu Asn
 1               5                  10                  15      
Asn Ser Gln Gln Asn Lys Glu
            20              


<210> 5173
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5173
Ala Ser Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly
 1               5                  10              


<210> 5174
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5174
Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser
 1               5                  10                  15      
Val Glu Asn Tyr Thr Leu Thr Ile Asn
            20                  25  


<210> 5175
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5175
Arg Gln Asn Arg Ser Phe Glu Gly Met Val Val Ala Ala Leu Leu Ala
 1               5                  10                  15      
Gly Arg Ala Leu Gln Gly Leu Arg Arg Leu
            20                  25      


<210> 5176
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5176
Arg Asn Val Thr Tyr Gly Thr Tyr Leu Asp Asp Pro Asp Pro Asp Asp
 1               5                  10                  15      
Gly Phe Asn Tyr Lys Gln
            20          


<210> 5177
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5177
Arg Asn Leu Thr Glu Val Pro Thr Asp Leu Pro Ala Tyr Val Arg Asn
 1               5                  10                  15      


<210> 5178
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5178
Arg Leu Thr Val Leu Gln Ala Ser Pro Gln Asp Thr Gly Asn Tyr Ser
 1               5                  10                  15      
Cys His Val Glu Glu Trp Leu Pro Ser Pro Gln Lys Glu
            20                  25                  


<210> 5179
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5179
Arg Cys Asn Ser Asp Leu Arg Asn Lys Thr Tyr Phe Ser Pro Arg Ile
 1               5                  10                  15      


<210> 5180
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5180
Arg Ala Ser Val Ser Phe Leu Asn Phe Asn Leu Ser Asn Cys Glu Arg
 1               5                  10                  15      
Lys
    


<210> 5181
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5181
Pro Gly Tyr Lys Leu Ala Ala Asp Asn Lys Ser Ser Ile Asp Leu Cys
 1               5                  10                  15      
Ala Glu Gly Thr His Gly Cys
            20              


<210> 5182
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5182
Lys Val Leu His Asn Gly Thr Leu Ala Glu Leu Gln Gly Leu Pro His
 1               5                  10                  15      
Ile Arg Val
            


<210> 5183
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5183
Lys Ser Met Ala Gly Ser Gly His Asn Val Ser Gln Glu Ala Leu Ala
 1               5                  10                  15      
Ile Lys Arg
            


<210> 5184
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5184
Lys Asn Phe Thr Ala Leu Ile Pro Gly Thr Thr Val Glu Ile Leu Asp
 1               5                  10                  15      
Gly Asp Ser Lys Asn
            20      


<210> 5185
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5185
Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met Ala Val Gln Gly Ser
 1               5                  10                  15      
Thr Ala Tyr Leu
            20  


<210> 5186
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5186
Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser
 1               5                  10                  15      
Ser Pro Asn Glu Thr Lys Tyr
            20              


<210> 5187
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5187
Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn Thr Thr Tyr
 1               5                  10              


<210> 5188
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5188
Arg Val Asn Ile Thr Tyr Asn Tyr Pro Val Arg Ala
 1               5                  10          


<210> 5189
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5189
Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile
 1               5                  10              


<210> 5190
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5190
Arg Ser Val Asn Pro Asn Asp Thr Cys Leu Ala Ser Cys Val Lys Ser
 1               5                  10                  15      


<210> 5191
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5191
Arg Leu Asn Asn Ile Ser Ile Ile Gly Pro Leu Asp Met Lys Gln
 1               5                  10                  15  


<210> 5192
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5192
Arg Phe Gly His Phe Thr Gly Phe Asn Ser Ser Thr Leu Lys Asp
 1               5                  10                  15  


<210> 5193
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5193
Arg Asp Cys Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala
 1               5                  10                  15      
Leu Asn His Phe Arg Ser
            20          


<210> 5194
<211> 34
<212> PRT
<213> Homo sapiens

<400> 5194
Leu Ser Phe Gly Glu Asp Tyr Pro Gly Ile Val Asn Pro Leu Asp His
 1               5                  10                  15      
Thr Asn Val Thr Ala Pro Gln Ala Ser Met Met Phe Gln Tyr Phe Val
            20                  25                  30          
Lys Val
        


<210> 5195
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5195
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
 1               5                  10                  15      
Lys Tyr
        


<210> 5196
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5196
Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg
 1               5                  10                  15      
Ala
    


<210> 5197
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5197
Lys Asp Leu Asn Glu Asp Asp His His His Glu Cys Leu Asn Val Thr
 1               5                  10                  15      
Gln Leu Leu Lys Tyr
            20      


<210> 5198
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5198
Lys Cys Ile Pro Val Met Glu Ala Gln Glu Tyr Ile Ala Asn Val Thr
 1               5                  10                  15      
Ser Ser Ser Ser Ala Lys Phe
            20              


<210> 5199
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5199
Thr Phe Gly Asn His Ser Ser Gly Asp Phe Asp Asp Gly Phe Leu Arg
 1               5                  10                  15      
Arg
    


<210> 5200
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5200
Ser Leu Leu Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser
 1               5                  10                  15      
Lys Val
        


<210> 5201
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5201
Ser Gly Lys Thr Val Glu Ile Asn Asn Thr Asp Ala Glu Gly Arg Leu
 1               5                  10                  15      
Val Leu Ala Asp Gly Val Ser Tyr Ala Cys Lys Asp
            20                  25              


<210> 5202
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5202
Ser Ala Phe Gly Asn Ile Leu Ser Cys Lys Val Val Cys Asp Asp Asn
 1               5                  10                  15      
Gly Ser Lys Gly
            20  


<210> 5203
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5203
Arg Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln Glu
 1               5                  10                  15      
Asp Ala Gly Ser Tyr Thr
            20          


<210> 5204
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5204
Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala Ile Asn Asn Thr Lys
 1               5                  10                  15      
Ser
    


<210> 5205
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5205
Arg Ser Val Gly Cys Ile Met Gly Glu Leu Leu Asn Gly Ser Pro Leu
 1               5                  10                  15      
Phe Pro Gly Lys Asn
            20      


<210> 5206
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5206
Arg Ser Arg Lys Pro Glu Asn Gln Gln Phe Pro Asp Thr Glu Asn Glu
 1               5                  10                  15      
Glu Tyr His Ser Asp Glu Gln Asn Asp Thr Arg Lys
            20                  25              


<210> 5207
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5207
Arg Gln Asp Cys Cys Gly Asn Cys Ser Asp Ser Glu Glu Glu Leu Pro
 1               5                  10                  15      
Thr Arg Leu
            


<210> 5208
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5208
Arg Asn Pro Thr Gln Phe Gln Leu Pro Asn Glu Leu Thr Cys Thr Thr
 1               5                  10                  15      
Ala Leu Pro Gly Ser Ser Lys Arg Arg
            20                  25  


<210> 5209
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5209
Arg Met Thr Arg Asn Lys Ala Asn Thr Met Ala Asn Gln Ser Lys Gln
 1               5                  10                  15      


<210> 5210
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5210
Arg Leu Glu Met Thr Ala Ala Lys Asn Thr Asn Asn Asn Gln Ser Pro
 1               5                  10                  15      
Ser Ala Pro Pro Ala Lys Pro
            20              


<210> 5211
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5211
Arg Lys Met Ala Ser Val Asn Gly Ser Ser Gln Asn Cys Val Ser Gly
 1               5                  10                  15      
Gln Glu Arg Gly
            20  


<210> 5212
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5212
Arg Lys Leu Leu Gly Asn Val Ser Leu Ser Leu Leu Tyr Lys Ser
 1               5                  10                  15  


<210> 5213
<211> 35
<212> PRT
<213> Homo sapiens

<400> 5213
Arg Lys Glu Met Asp Asn Val Ser Ile Leu Ser Ser Gln Pro Glu Gly
 1               5                  10                  15      
Ser Leu Gln Ser Trp Leu Ser Cys Thr Leu Ser Leu Ala Thr Asp Thr
            20                  25                  30          
Met Arg Thr
        35  


<210> 5214
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5214
Arg Phe Gln Leu Pro Gly Asn Ile Gly Phe Asp Cys His Leu Asn Gly
 1               5                  10                  15      
Thr Ala Ser Gln Lys Lys Ser
            20              


<210> 5215
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5215
Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met
 1               5                  10                  15      
Met
    


<210> 5216
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5216
Arg Asp Val Ala Cys Gly Ala Asn His Thr Leu Val Leu Asp Ser Gln
 1               5                  10                  15      
Lys Arg Val
            


<210> 5217
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5217
Arg Ala Trp Asn Trp Ser Asn Ser Ile Thr Ser Ser Pro Phe Val Ser
 1               5                  10                  15      
Phe Lys Pro
            


<210> 5218
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5218
Gln Ser Ser Met Ser Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln
 1               5                  10                  15      
Asp Asn Lys Ser
            20  


<210> 5219
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5219
Gln Glu Lys Asn Ile Thr Ala Leu Glu Lys Ala Ile Leu Asp Gln Glu
 1               5                  10                  15      
Gly Pro Ala Lys Val Ala His Thr Arg Leu
            20                  25      


<210> 5220
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5220
Pro Val Gly Gly Asn Val Thr Ser Ser Phe Ser Gly Asp Asp Leu Glu
 1               5                  10                  15      
Cys Arg Glu
            


<210> 5221
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5221
Pro Asn Ala Ser Trp Cys Ser Asp Met Leu Ser Leu Tyr Gln Glu Phe
 1               5                  10                  15      
Leu Glu Lys Thr Lys Ser
            20          


<210> 5222
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5222
Asn Gln Asn Arg Ser Met Glu Ala His Asn Ile Leu Ser Lys Arg
 1               5                  10                  15  


<210> 5223
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5223
Met Ser Glu Val Val Gln Thr Cys Arg Asn Phe Ile Lys Asp Ala Leu
 1               5                  10                  15      
Asn Ile Ser Ile Lys Ser
            20          


<210> 5224
<211> 9
<212> PRT
<213> Homo sapiens

<400> 5224
Met Asn Glu Thr Ile Phe Met Lys Phe
 1               5                  


<210> 5225
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5225
Met Met Ala Ala Ala Pro Ile Gln Gln Asn Gly Thr His Thr Gly Val
 1               5                  10                  15      
Pro Ile Asp Leu Asp Pro Pro Asp Ser Arg Lys
            20                  25          


<210> 5226
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5226
Leu Val Ser Pro Gly Ser Ala Asn Glu Thr Ser Ser Ile Leu Val Glu
 1               5                  10                  15      
Ser Val Thr Arg Ser
            20      


<210> 5227
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5227
Leu Leu Ala Ala Thr Ala Asn Thr Ser Ser Ser Gln Leu Ala Ala Leu
 1               5                  10                  15      
Leu Gln Leu Gln His Gln Leu Arg
            20                  


<210> 5228
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5228
Lys Tyr Ser Asn Met Ser Thr Leu Gly Asn Asn Gly Pro Thr His Lys
 1               5                  10                  15      
Lys Leu
        


<210> 5229
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5229
Lys Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr
 1               5                  10      


<210> 5230
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5230
Lys Tyr Ile Leu Thr Val Glu Asn Ser Ser Gly Ser Lys Ser
 1               5                  10                  


<210> 5231
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5231
Lys Val Glu Ser Met Ser Glu Ser Asp Thr Met Asn Val Ser Asn Leu
 1               5                  10                  15      
Ser Gln Gly Val Met Leu Ser
            20              


<210> 5232
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5232
Lys Arg Ile Gln Lys Glu Leu Ala Asp Ile Thr Leu Asp Pro Pro Pro
 1               5                  10                  15      
Asn Cys Ser Ala Gly Pro Lys Gly
            20                  


<210> 5233
<211> 10
<212> PRT
<213> Homo sapiens

<400> 5233
Lys Met Ser Ser Phe Asn Leu Ser Arg Ile
 1               5                  10  


<210> 5234
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5234
Lys Met Phe Phe Pro Asn Leu Thr Ala Tyr Met Ser Ser Gly Pro Leu
 1               5                  10                  15      
Val Ala Met Ile Leu Ala Arg His
            20                  


<210> 5235
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5235
Lys Leu Thr Leu Gln Pro Val Asp Asn Ser Thr Ile Ser Leu Gln Met
 1               5                  10                  15      
Gly Thr Asn Lys Val
            20      


<210> 5236
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5236
Lys Leu Leu Pro Ala Phe Asn Thr Thr Ser Gly Leu Pro Tyr Pro Arg
 1               5                  10                  15      
Ile
    


<210> 5237
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5237
Lys Lys Pro Lys Gly Gly Pro Asn Ala Ser Ser Ser Ser Ala Thr Ile
 1               5                  10                  15      
Ser Lys Gln
            


<210> 5238
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5238
Lys Lys Ala Lys Met Glu Pro Asn Ala Ser Glu Ser Ala Ile Pro Ala
 1               5                  10                  15      
Arg Arg Gln
            


<210> 5239
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5239
Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe Val Asn Tyr Ser Asp
 1               5                  10                  15      
Pro Asn Asp Ala Asp Lys Ala
            20              


<210> 5240
<211> 30
<212> PRT
<213> Homo sapiens

<400> 5240
Lys Gly Ser Gly Pro Ser Gly Gly Ser Gly Gly Gly Ala Asn Gly Thr
 1               5                  10                  15      
Ser Phe Ser Tyr Thr Phe His Gly Asp Pro His Ala Met Phe
            20                  25                  30  


<210> 5241
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5241
Lys Gly Asn Gly Ser Pro Val Asn Gly Ser Ser Gln Gln Gly Thr Ser
 1               5                  10                  15      
Asn Pro Ser Leu Gly Ser Asn Ile Pro Ser
            20                  25      


<210> 5242
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5242
Lys Phe His Lys Phe Asp Ser Cys Glu Asn Ser Leu Lys Ser Asn Ser
 1               5                  10                  15      
Asp Leu Leu Asn Tyr Asn Arg Ser
            20                  


<210> 5243
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5243
Lys Glu Asn Pro Gly Phe Asp Phe Ser Gly Ala Glu Ile Ser Gly Asn
 1               5                  10                  15      
Tyr Thr Lys Gly
            20  


<210> 5244
<211> 31
<212> PRT
<213> Homo sapiens

<400> 5244
Lys Asp Gln Lys Val Pro His Ser Gly Lys Thr Glu Gly Ser Thr Ala
 1               5                  10                  15      
Gly Ala Gln Ile Pro Ser Lys Val Ser Val Asn Val Ser Ser His
            20                  25                  30      


<210> 5245
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5245
Lys Cys Gly Lys Ala Phe Thr Gln Ser Ser Asn Leu Thr Val His Gln
 1               5                  10                  15      
Lys
    


<210> 5246
<211> 39
<212> PRT
<213> Homo sapiens

<400> 5246
Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr Ala Leu
 1               5                  10                  15      
Ile Asn Ser Thr Gly Glu Gly Ser His Cys Ser Ser Ser Gly Asp Pro
            20                  25                  30          
Ala Glu Tyr Asn Leu Arg Ser
        35                  


<210> 5247
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5247
Lys Ala Leu Trp Pro Gly Asp Leu Asn Gly Ser Gly Ser Gly Trp Ala
 1               5                  10                  15      
Thr Pro Ile Arg Pro
            20      


<210> 5248
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5248
Lys Ala Leu Gly Ile Tyr Val Ile Val Val Asn Cys Ser Glu Gly Leu
 1               5                  10                  15      
Asp Tyr Lys Ser Met Gly Arg Met Tyr Ser Gly
            20                  25          


<210> 5249
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5249
Gly Leu Thr Asn Leu Ser Lys Met Pro Ala Cys Asn Ile Met Leu Leu
 1               5                  10                  15      
Gly Ala Gln Arg Lys Thr
            20          


<210> 5250
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5250
Phe Met Lys Thr Leu Asn Tyr Thr Ala Arg Phe
 1               5                  10      


<210> 5251
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5251
Phe Gly Pro Lys Asn Arg Ser Ile Gly Ala Ala Ala Lys Ser Gln Val
 1               5                  10                  15      
Ile Ser Asn Ala Lys Asn
            20          


<210> 5252
<211> 40
<212> PRT
<213> Homo sapiens

<400> 5252
Glu Leu Asp Lys Ser Asn Ser Pro Leu Thr Met Ala Leu Cys Gly Ser
 1               5                  10                  15      
Lys Gly Ser Phe Ile Asn Ile Ser Gln Met Ile Ala Cys Val Gly Gln
            20                  25                  30          
Gln Ala Ile Ser Gly Ser Arg Val
        35                  40  


<210> 5253
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5253
Glu Glu Arg Met Phe Lys Glu Asn Gln Ser Leu Phe Ser Glu Val Ala
 1               5                  10                  15      
Ser Leu Lys Glu Gln Met
            20          


<210> 5254
<211> 27
<212> PRT
<213> Homo sapiens

<400> 5254
Glu Ala Arg Thr Glu Ser Ser Gln Ala Ser Asp Met Met Asp Thr Met
 1               5                  10                  15      
Asp Val Glu Asn Asn Ser Thr Leu Glu Lys His
            20                  25          


<210> 5255
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5255
Arg Val Cys Asn Leu Thr Ser Arg Gly Met Asp Ser Cys Glu Val Met
 1               5                  10                  15      
Cys Cys Gly Arg Gly Tyr Asp Thr
            20                  


<210> 5256
<211> 34
<212> PRT
<213> Homo sapiens

<400> 5256
Arg Thr Ile Asp Thr Thr Pro Ser Gly Gly Asn Thr Thr Pro Ser Gly
 1               5                  10                  15      
Thr Gly Ile Thr Leu Asp Thr Thr Leu Ser Ala Thr Glu Thr Thr Phe
            20                  25                  30          
Glu Tyr
        


<210> 5257
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5257
Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn Asp Gln Pro
 1               5                  10                  15      
Pro Gln Pro Ser
            20  


<210> 5258
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5258
Arg Ser Leu Glu Glu Ile Gly Ile Gln Asn Tyr Ser Thr Thr Ser Ser
 1               5                  10                  15      
Cys Gln Ala Arg
            20  


<210> 5259
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5259
Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp
 1               5                  10      


<210> 5260
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5260
Arg Leu Ile Asn Lys Phe Asn Ser Ser Ser Ser Ser Leu Glu Glu Lys
 1               5                  10                  15      
Ile
    


<210> 5261
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5261
Arg Ile Phe Met Asn Thr Cys Asn Pro Ser Ser Leu Thr Gln Gln Trp
 1               5                  10                  15      
Leu Phe Glu His Thr Asn Ser Thr Val Leu Glu Lys Phe
            20                  25                  


<210> 5262
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5262
Arg Gly Pro Gly Cys Asp Glu Leu Asp Cys Gly Pro Ser Asn Cys Ser
 1               5                  10                  15      
Gln His Gly Leu Cys Thr Glu Thr Gly Cys Arg Cys
            20                  25              


<210> 5263
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5263
Arg Asp Ser Ala Asn Ala Thr Ser Leu Pro Gly Ser Arg Arg Arg
 1               5                  10                  15  


<210> 5264
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5264
Pro Val Val Leu Ala Pro Asn His Thr Asp His Cys His Tyr Gln Gly
 1               5                  10                  15      
Arg Val Arg Gly
            20  


<210> 5265
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5265
Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu Lys Leu
 1               5                  10                  15  


<210> 5266
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5266
Lys Asn Ala Asn Gly Ser Tyr Thr Cys Glu Glu Cys Asp Ser Ser Cys
 1               5                  10                  15      
Val Gly Cys Thr Gly Glu Gly Pro Gly Asn Cys Lys Glu
            20                  25                  


<210> 5267
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5267
Gly Leu Gln Gln Thr Asn Phe Ser Ser Ala Phe Ser Ser Asp Ser Lys
 1               5                  10                  15      
Ser
    


<210> 5268
<211> 31
<212> PRT
<213> Homo sapiens

<400> 5268
Glu Arg Thr Gly Pro Ser Gly Thr Val Leu Val Phe Cys Asn Ser Ser
 1               5                  10                  15      
Ser Thr Val Asn Trp Leu Gly Tyr Ile Leu Asp Asp His Lys Ile
            20                  25                  30      


<210> 5269
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5269
Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr
 1               5                  10              


<210> 5270
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5270
Lys Leu Gln Asn Asn Ile Ser Tyr Gln Met Ala Asp Ile His His
 1               5                  10                  15  


<210> 5271
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5271
Thr Ala Ala Asn Val Thr Val Ser Leu Pro Val Arg Gly
 1               5                  10              


<210> 5272
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5272
Arg Val Ala Gly Thr Ala Val Ser Ile Ser Cys Asn Val Thr Gly Tyr
 1               5                  10                  15      
Glu Gly Pro Ala Gln Gln Asn
            20              


<210> 5273
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5273
Arg Thr Met Asn Ala Ser Leu Ala Gln Gln Leu Cys Arg Gln
 1               5                  10                  


<210> 5274
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5274
Arg Ser Met Ala Ile Met Asn Asn Val Ser Leu Ala Leu His Arg Cys
 1               5                  10                  15      


<210> 5275
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5275
Arg Ser Asp Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu
 1               5                  10                  15  


<210> 5276
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5276
Arg Met Leu Glu Met Gly Ala Ile Lys Asn Leu Thr Ser Phe
 1               5                  10                  


<210> 5277
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5277
Arg Leu Ser Cys Ala Phe Lys Thr Glu Asn Gln Thr Arg Gln
 1               5                  10                  


<210> 5278
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5278
Arg Leu Asn Pro Gly Asn Tyr Thr Ala Arg Ile
 1               5                  10      


<210> 5279
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5279
Arg Ile Val Ser Pro Glu Pro Gly Gly Ala Val Gly Pro Asn Leu Thr
 1               5                  10                  15      
Cys Arg Trp
            


<210> 5280
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5280
Arg Ile Ser Gly Ser Glu Val Glu Glu Leu Ser Glu Val Ser Asn Phe
 1               5                  10                  15      
Thr Met Glu Asp Ile Asn Asn Lys Lys Ile
            20                  25      


<210> 5281
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5281
Arg Glu Thr Asn Ala Ile His Asn Ile Thr Val Leu Ala Met Glu Ser
 1               5                  10                  15      
Gln Asn Pro Ser Gln Val Gly Arg Gly
            20                  25  


<210> 5282
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5282
Arg Glu His Val His Asn Ala Ser Ala His Leu Thr Phe Asn Lys Phe
 1               5                  10                  15      


<210> 5283
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5283
Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys Leu
 1               5                  10                  15      
Asn Asn
        


<210> 5284
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5284
Gln Val Asp Thr Val Val Pro Asn Ala Thr Val Ser Glu Lys Ala
 1               5                  10                  15  


<210> 5285
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5285
Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val Asn Cys Thr Lys
 1               5                  10                  15      
Ile
    


<210> 5286
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5286
Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn
 1               5                  10                  15  


<210> 5287
<211> 34
<212> PRT
<213> Homo sapiens

<400> 5287
Met Met Val Arg Lys Gly Asp Thr Ala Val Leu Arg Cys Tyr Leu Glu
 1               5                  10                  15      
Asp Gly Ala Ser Lys Gly Ala Trp Leu Asn Arg Ser Ser Ile Ile Phe
            20                  25                  30          
Ala Gly
        


<210> 5288
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5288
Leu Val Leu Gln Asp Ser Ala Ala Gly Phe Ile Ala Asn Leu Ser Val
 1               5                  10                  15      
Gln Arg Gln
            


<210> 5289
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5289
Lys Val Val Asn Thr Ser Asp Pro Asp Met Arg Arg Glu
 1               5                  10              


<210> 5290
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5290
Lys Thr Ser Asn Ser Ser Gln Val Ser Asn Glu Gln Asp Lys Ile Asp
 1               5                  10                  15      
Ala Tyr Lys Leu
            20  


<210> 5291
<211> 34
<212> PRT
<213> Homo sapiens

<400> 5291
Lys Ser Phe Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr
 1               5                  10                  15      
Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser
            20                  25                  30          
Arg Tyr
        


<210> 5292
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5292
Lys Lys Ser Gln Gly Ile Gln Asn Cys Ser Gln Ser Leu Leu Gly Cys
 1               5                  10                  15      
Ser Cys Pro Cys Ala Trp Ser Arg Cys
            20                  25  


<210> 5293
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5293
Lys Ala Lys Gln Cys Asn Gly Thr Ser Thr Cys Trp Cys Val Asn Thr
 1               5                  10                  15      
Ala Gly Val Arg Arg
            20      


<210> 5294
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5294
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
 1               5                  10                  15      
Thr Phe Pro Lys Gly
            20      


<210> 5295
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5295
His Ala Val Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr
 1               5                  10                  15      
Asn Ala Val Gly Met Gly Arg Ala
            20                  


<210> 5296
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5296
Phe Ala Ala Trp Asp Asp Asp Glu Pro Trp Gly Pro Trp Thr Gly Asn
 1               5                  10                  15      
Gly Thr Phe Trp Leu Pro Arg Val
            20                  


<210> 5297
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5297
Cys Ser Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu
 1               5                  10                  15      
Asn Asp Ser Lys Cys
            20      


<210> 5298
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5298
Ala Gln Asp Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser
 1               5                  10                  15      
Pro Asp Gly Pro Gly Gly Arg Cys
            20                  


<210> 5299
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5299
Tyr Leu Leu Gly Pro Asp Lys Asn Phe Thr Arg Glu
 1               5                  10          


<210> 5300
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5300
Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser
 1               5                  10          


<210> 5301
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5301
Arg Thr Thr Leu Val Asp Asn Asn Thr Trp Asn Asn Ser His Ile Ala
 1               5                  10                  15      
Leu Val Gly
            


<210> 5302
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5302
Arg Ser Cys Ile Leu Asn Gly Thr Val Met Leu Asp Met Arg Ala
 1               5                  10                  15  


<210> 5303
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5303
Arg Gln Thr Met Ile Asp Phe Leu Gln Asn His Thr Glu Gly Ser Arg
 1               5                  10                  15      
Pro Pro Ala Cys Pro Arg Leu
            20              


<210> 5304
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5304
Arg Leu Asn Trp Thr Ser Leu Leu Pro Ala Ser Phe Thr Lys Asn
 1               5                  10                  15  


<210> 5305
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5305
Arg Lys Thr Tyr Ala Ile Tyr Asp Leu Leu Asp Thr Ala Met Ile Asn
 1               5                  10                  15      
Asn Ser Arg Asn
            20  


<210> 5306
<211> 15
<212> PRT
<213> Homo sapiens

<400> 5306
Arg Lys Asn Ser Ser Thr Ser Thr Ser Ser Ser Gly Ser Arg Arg
 1               5                  10                  15  


<210> 5307
<211> 31
<212> PRT
<213> Homo sapiens

<400> 5307
Arg Ile Val Asn Ala Thr Trp Phe Thr Asn Phe Ile Leu Leu Phe Ile
 1               5                  10                  15      
Leu Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ala
            20                  25                  30      


<210> 5308
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5308
Arg Asp Arg Asn Leu Thr Asn Cys Ser Ser Val Met Leu Pro Ser Asn
 1               5                  10                  15      
Asp Asp Arg Ala
            20  


<210> 5309
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5309
Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Ala
 1               5                  10                  15      
Val Leu
        


<210> 5310
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5310
Pro Glu Gln Lys His Thr Ala Glu Tyr Ala Ala Asn Ile Thr Lys Ser
 1               5                  10                  15      


<210> 5311
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5311
Pro Glu Pro Leu Val Gly Asn Leu Ser Gly Ile Glu Lys Glu
 1               5                  10                  


<210> 5312
<211> 13
<212> PRT
<213> Homo sapiens

<400> 5312
Leu Arg Asn Leu Thr Ile Val Asp Ser Gly Leu Lys Phe
 1               5                  10              


<210> 5313
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5313
Leu Asp Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser
 1               5                  10                  15      
Pro Thr Val Arg Arg
            20      


<210> 5314
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5314
Lys Thr Gly Ser Ile Cys Ala Ser Glu Asn Ile Asn Asp Thr Leu Thr
 1               5                  10                  15      
Arg Tyr
        


<210> 5315
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5315
Lys Ser Asn Phe Ser Leu Glu Asp Phe Gln His Ser Lys Gly
 1               5                  10                  


<210> 5316
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5316
Lys Arg His Thr Asn Val Ser Ile Leu Tyr Ala
 1               5                  10      


<210> 5317
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5317
Lys Gln Asp Gly Pro Met Pro Lys Pro His Ser Val Ser Leu Asn Asp
 1               5                  10                  15      
Thr Glu Thr Arg Lys
            20      


<210> 5318
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5318
Lys Asn Phe Ile Ile Asn Met Thr Cys Arg Phe
 1               5                  10      


<210> 5319
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5319
Lys Ile Leu Gly Asp Lys Val Asn Asn Thr Ala Val Ile Glu Lys Gln
 1               5                  10                  15      


<210> 5320
<211> 21
<212> PRT
<213> Homo sapiens

<400> 5320
Lys His Leu Thr Asn Asp Thr Thr Thr Pro Glu Ser Thr Met Thr Ser
 1               5                  10                  15      
Gly Gln Ala Arg Ala
            20      


<210> 5321
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5321
Lys Glu Lys Arg Pro Val Thr Arg Pro Asp Cys Met Cys Asp Thr Phe
 1               5                  10                  15      
Asp Gln Cys Ala Glu Asn Ile Ser Lys Lys
            20                  25      


<210> 5322
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5322
Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile His Asn Gly
 1               5                  10                  15      
Thr Tyr Ile Cys Asp Val Lys Asn
            20                  


<210> 5323
<211> 12
<212> PRT
<213> Homo sapiens

<400> 5323
Ile Leu Thr Leu Asn Cys Thr Leu Leu Leu Lys Thr
 1               5                  10          


<210> 5324
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5324
Gly Asn Cys Thr Phe Ile Pro Gly Phe Thr Ala Met Thr Glu Lys Phe
 1               5                  10                  15      


<210> 5325
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5325
Glu Gly Ala Leu Arg Gly Pro His Gly Ser Leu Ser Ala Phe Leu Asn
 1               5                  10                  15      
Ala Ser Arg Val Arg Glu
            20          


<210> 5326
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5326
Asp Asp Cys Val Ser Ile Met Asn Gly Thr Asp Glu Gly Val Ser Ala
 1               5                  10                  15      
Trp
    


<210> 5327
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5327
Met Thr Leu Gly Ser Leu Gly Asn Ser Ser Ser Ser Val Ser Ala Thr
 1               5                  10                  15      
Phe Leu Leu Ser Gly Ile Pro Gly Leu Glu Arg Met
            20                  25              


<210> 5328
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5328
Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn His Ser Gly Gln
 1               5                  10                  15      
Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly
            20                  25      


<210> 5329
<211> 39
<212> PRT
<213> Homo sapiens

<400> 5329
Arg Ser Gln Gln Val Asn Asn Phe Thr Ser Asn Asp Val Asp Met Glu
 1               5                  10                  15      
Thr Asp His Tyr Ser Asn Gly Val Gly Glu Thr Ser Ser Asn Gly Phe
            20                  25                  30          
Leu Asn Gly Ser Ser Lys His
        35                  


<210> 5330
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5330
Arg Gln Thr His Phe Ser Thr Arg Leu His Thr Ala Ala Thr Glu Gly
 1               5                  10                  15      
Leu Pro Asn Ser Ser Ile Lys Asn Gln
            20                  25  


<210> 5331
<211> 19
<212> PRT
<213> Homo sapiens

<400> 5331
Arg Asn Asp Gly Asn Asp Ser Gly Thr Met Leu Pro Glu Ala Leu Asn
 1               5                  10                  15      
Tyr Ile Leu
            


<210> 5332
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5332
Arg Asn Ala Arg Gly Ala Pro Met Asp Pro Asn Glu Ser Pro Ala Ala
 1               5                  10                  15      
Pro Glu Ala Ala Leu Pro Lys Ala Gly Lys
            20                  25      


<210> 5333
<211> 28
<212> PRT
<213> Homo sapiens

<400> 5333
Arg Asn Thr Thr Ile Ser Leu Leu Thr Thr Asp Asp Ala Met Val Ser
 1               5                  10                  15      
Ile Asp Pro Thr Met Pro Ala Asn Ser Glu Arg Ala
            20                  25              


<210> 5334
<211> 35
<212> PRT
<213> Homo sapiens

<400> 5334
Arg Asn His Ser Leu Glu Pro Leu Ser Thr Phe Leu Thr Tyr Met Thr
 1               5                  10                  15      
Cys Ser Tyr Met Ile Asp Asn Val Ile Leu Leu Met Asn Gly Ala Leu
            20                  25                  30          
Gln Lys Lys
        35  


<210> 5335
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5335
Arg Lys Thr Leu Gln Asp Asn Gln Leu Cys Met Glu Glu Ala Met Asn
 1               5                  10                  15      
Ser Ser His Asp Lys Lys
            20          


<210> 5336
<211> 34
<212> PRT
<213> Homo sapiens

<400> 5336
Arg His Phe Thr Asn Asp Thr Ile Leu Asp Val Phe Phe Tyr Asn Ser
 1               5                  10                  15      
Pro Thr Tyr Cys Gln Thr Ile Val Asp Thr Val Ala Ser Glu Met Asn
            20                  25                  30          
Arg Ile
        


<210> 5337
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5337
Arg Phe Pro Ser Ala Met Val Val Thr Asp Thr Ser Ser Ile Ser Thr
 1               5                  10                  15      
Leu Thr Asn Met Ser Ser Ser Lys Gln
            20                  25  


<210> 5338
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5338
Arg Asp Asn His Ser Gly Gly Ser Arg Pro Pro Leu Leu Pro Pro Gly
 1               5                  10                  15      
Gly Arg
        


<210> 5339
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5339
Gln Glu Lys Gln Ile Lys Pro Asn Leu Thr Lys Leu Arg Lys
 1               5                  10                  


<210> 5340
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5340
Pro Glu Ser Ala Asp Met Phe Asp Asn Gly Ser Phe Leu Arg Arg Arg
 1               5                  10                  15      
Lys
    


<210> 5341
<211> 33
<212> PRT
<213> Homo sapiens

<400> 5341
Asn Leu Phe Gln Gln Gln Ala Ala Ala Ala Ala Asn Asn Thr Ala Ser
 1               5                  10                  15      
Gln Gln Ala Ala Ser Gln Ala Gln Pro Gly Gln Gln Gln Val Leu Arg
            20                  25                  30          
Ala
    


<210> 5342
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5342
Lys Val Met Pro Cys Leu Ala Pro Ile Ala Ala Lys Val Gly Ser Val
 1               5                  10                  15      
Gly His Lys Met Asn Leu Thr Gly Asn Asp
            20                  25      


<210> 5343
<211> 37
<212> PRT
<213> Homo sapiens

<400> 5343
Lys Thr Ser Thr Glu Cys Ala Ser Ser Thr Glu Asn Ser Phe Val Val
 1               5                  10                  15      
Ser Ser Ser Ser Val Ser Asn Thr Thr Val Ala Gly Thr Pro Pro Tyr
            20                  25                  30          
Pro Thr Ser Arg Arg
        35          


<210> 5344
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5344
Lys Gly Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala
 1               5                  10                  15      
Tyr Asp Glu Thr Leu Asn Val Leu Lys Phe
            20                  25      


<210> 5345
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5345
Lys Glu Ile Leu Tyr Trp Phe Ala Asn Ser Thr Gln Trp Thr Lys Ala
 1               5                  10                  15      


<210> 5346
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5346
Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val
 1               5                  10                  15      
Val Ala Asn Arg Ser Asn Asp
            20              


<210> 5347
<211> 30
<212> PRT
<213> Homo sapiens

<400> 5347
Gly Met Met Gly Val Asn Ser Phe Ser Gly Gln Leu Ala Val Asn Val
 1               5                  10                  15      
Ser Glu Ala Ser Gln Ala Thr Asn Gln Gly Phe Thr Arg Asn
            20                  25                  30  


<210> 5348
<211> 16
<212> PRT
<213> Homo sapiens

<400> 5348
Gly Lys Ser Phe Ser Gln Leu Cys Asn Leu Thr Arg His Gln Arg Ile
 1               5                  10                  15      


<210> 5349
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5349
Asp Asp Asp Leu Leu Asn Val Thr Leu Asp Ser Val Asn Glu Thr Gly
 1               5                  10                  15      
Ser Thr Ala Leu Ser Ile Ala Arg Ala
            20                  25  


<210> 5350
<211> 25
<212> PRT
<213> Homo sapiens

<400> 5350
Met Arg Lys Asn Glu Ser Tyr Leu Asn Gln Pro Ala Pro Pro Ile Pro
 1               5                  10                  15      
Ile Pro Thr Leu Ser Leu Met Gly Gly
            20                  25  


<210> 5351
<211> 17
<212> PRT
<213> Homo sapiens

<400> 5351
Val Ser Phe Phe Cys Asn Asn Ser Tyr Val Leu Ser Gly Asn Glu Lys
 1               5                  10                  15      
Arg
    


<210> 5352
<211> 30
<212> PRT
<213> Homo sapiens

<400> 5352
Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr
 1               5                  10                  15      
Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn
            20                  25                  30  


<210> 5353
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5353
Lys Thr Thr Val Ser Cys Thr Lys Ile Met Ser Lys Asn Ile Ser Ile
 1               5                  10                  15      
Val Asp Asn Glu Lys Cys Lys Tyr
            20                  


<210> 5354
<211> 23
<212> PRT
<213> Homo sapiens

<400> 5354
Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser Ser Ala Ser
 1               5                  10                  15      
Ala Asp Leu Val Val Arg Gly
            20              


<210> 5355
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5355
Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser Asn Ala Leu Ile
 1               5                  10                  15      
Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly
            20                  25      


<210> 5356
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5356
Lys Val Val Leu Ile Lys Asn Thr Leu Arg Ser Leu Glu Val Leu Asn
 1               5                  10                  15      
Leu Ser Ser Asn Lys Leu
            20          


<210> 5357
<211> 32
<212> PRT
<213> Homo sapiens

<400> 5357
Lys Arg Leu Thr Pro Asn Tyr Thr Leu Gly Ala Asn Gly Tyr Val Phe
 1               5                  10                  15      
Ala Ile Asp Leu Asn Gly Tyr Val Leu Leu His Pro Asn Leu Lys Pro
            20                  25                  30          


<210> 5358
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5358
Trp Asn Ala Ser Thr Thr Ile Leu Ser Leu Tyr Asp Val Ser Leu Ser
 1               5                  10                  15      
Arg Leu
        


<210> 5359
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5359
Arg Ala Arg Ala Met Gly Ile Asn Ala Thr Phe Ala Asn Ile Ala Gly
 1               5                  10                  15      
Ala Leu Ala Pro Leu Met Met Ile
            20                  


<210> 5360
<211> 24
<212> PRT
<213> Homo sapiens

<400> 5360
Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu Ser
 1               5                  10                  15      
Leu Thr Glu Ala Thr Glu Lys Ala
            20                  


<210> 5361
<211> 26
<212> PRT
<213> Homo sapiens

<400> 5361
Lys Met Val Asn His Ser Leu His Pro Thr Glu Pro Val Lys Val Thr
 1               5                  10                  15      
Leu Pro Asp Ala Phe Leu Pro Ala Gln Val
            20                  25      


<210> 5362
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5362
Lys Met Gly Asp Leu Tyr Tyr Tyr Gly His Gln Asn Gln Ser Gln Asp
 1               5                  10                  15      
Leu Glu Leu Ser
            20  


<210> 5363
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5363
Lys Glu Glu Glu Ile Phe Ser Leu Phe Asn Ser Ser Asp Thr Asn Leu
 1               5                  10                  15      
Gln Gly Gly Lys
            20  


<210> 5364
<211> 22
<212> PRT
<213> Homo sapiens

<400> 5364
Met Asp Leu Trp Asn Leu Ser Trp Phe Leu Phe Leu Asp Ala Leu Leu
 1               5                  10                  15      
Val Ile Ser Gly Leu Val
            20          


<210> 5365
<211> 385
<212> PRT
<213> Homo sapiens

<400> 5365
Met His Val Cys Val Cys Val Cys Val Cys Val Tyr Met Pro Val Cys
 1               5                  10                  15      
Val Asp Ala Cys Met Cys Cys Glu Ala Gly Arg Pro Ala Phe Arg Ser
            20                  25                  30          
Phe Leu Phe Ser Leu Cys Ser Asp Leu Gly Ala Val Ile Ser Leu Leu
        35                  40                  45              
Leu Trp Gly Arg Gln Leu Phe Ala Leu Tyr Ser Gly Asn Asp Val Thr
    50                  55                  60                  
Asp Ile Ser Asp Asp Arg Phe Pro Lys Pro Pro Glu Ile Ala Asn Gly
65                  70                  75                  80  
Tyr Val Glu His Leu Phe Arg Tyr Gln Cys Lys Asn Tyr Tyr Arg Leu
                85                  90                  95      
Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp
            100                 105                 110         
Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys Glu Ala Val Cys
        115                 120                 125             
Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln Arg Ile Leu Gly Gly
    130                 135                 140                 
His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln Ala Lys Met Val Ser
145                 150                 155                 160 
His His Asn Leu Thr Thr Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu
                165                 170                 175     
Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His Ser Glu Asn Ala Thr
            180                 185                 190         
Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln
        195                 200                 205             
Leu Val Glu Ile Glu Lys Val Val Leu His Pro Asn Tyr His Gln Val
    210                 215                 220                 
Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val Leu Val Asn Glu Arg
225                 230                 235                 240 
Val Met Pro Ile Cys Leu Pro Ser Lys Asn Tyr Ala Glu Val Gly Arg
                245                 250                 255     
Val Gly Tyr Val Ser Gly Trp Gly Gln Ser Asp Asn Phe Lys Leu Thr
            260                 265                 270         
Asp His Leu Lys Tyr Val Met Leu Pro Val Ala Asp Gln Tyr Asp Cys
        275                 280                 285             
Ile Thr His Tyr Glu Gly Ser Thr Cys Pro Lys Trp Lys Ala Pro Lys
    290                 295                 300                 
Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu His Thr Phe Cys Val
305                 310                 315                 320 
Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser
                325                 330                 335     
Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr Trp Tyr Ala Ala Gly
            340                 345                 350         
Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr
        355                 360                 365             
Val Lys Val Thr Ser Ile Gln His Trp Val Gln Lys Thr Ile Ala Glu
    370                 375                 380                 
Asn
385 


<210> 5366
<211> 416
<212> PRT
<213> Homo sapiens

<400> 5366
Thr Ala Leu Pro Glu Ala Arg Pro Thr Lys Met Ser Ala Leu Gly Ala
 1               5                  10                  15      
Val Ile Ala Leu Leu Leu Trp Gly Gln Leu Phe Ala Val Asp Ser Gly
            20                  25                  30          
Asn Asp Val Thr Asp Ile Ala Asp Asp Gly Cys Pro Lys Pro Pro Glu
        35                  40                  45              
Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys Asn
    50                  55                  60                  
Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn Asp
65                  70                  75                  80  
Lys Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys
                85                  90                  95      
Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr
            100                 105                 110         
Val Glu His Ser Val Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg
        115                 120                 125             
Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile
    130                 135                 140                 
Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly
145                 150                 155                 160 
Lys Pro Lys Asn Pro Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His
                165                 170                 175     
Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln Ala Lys Met Val Ser His
            180                 185                 190         
His Asn Leu Thr Thr Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu
        195                 200                 205             
Thr Thr Ala Lys Asn Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala
    210                 215                 220                 
Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu
225                 230                 235                 240 
Val Glu Ile Glu Lys Val Val Leu His Pro Asn Tyr Ser Gln Val Asp
                245                 250                 255     
Ile Gly Leu Ile Lys Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val
            260                 265                 270         
Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val
        275                 280                 285             
Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp
    290                 295                 300                 
His Leu Lys Tyr Val Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile
305                 310                 315                 320 
Arg His Tyr Glu Gly Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser
                325                 330                 335     
Pro Val Gly Val Gln Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly
            340                 345                 350         
Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala
        355                 360                 365             
Phe Ala Val His Asp Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile
    370                 375                 380                 
Leu Ser Phe Asp Lys Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val
385                 390                 395                 400 
Lys Val Thr Ser Ile Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn
                405                 410                 415     


<210> 5367
<211> 346
<212> PRT
<213> Homo sapiens

<400> 5367
Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu Phe
 1               5                  10                  15      
Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly Cys
            20                  25                  30          
Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg
        35                  40                  45              
Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val
    50                  55                  60                  
Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp
65                  70                  75                  80  
Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala
                85                  90                  95      
Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser
            100                 105                 110         
Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly
        115                 120                 125             
Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu
    130                 135                 140                 
Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr
145                 150                 155                 160 
Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val
                165                 170                 175     
Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu
            180                 185                 190         
Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro
        195                 200                 205             
Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp
    210                 215                 220                 
Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met
225                 230                 235                 240 
Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser
                245                 250                 255     
Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro
            260                 265                 270         
Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu
        275                 280                 285             
Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu
    290                 295                 300                 
Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser
305                 310                 315                 320 
Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln
                325                 330                 335     
Asp Trp Val Gln Lys Thr Ile Ala Glu Asn
            340                 345     


<210> 5368
<211> 418
<212> PRT
<213> Homo sapiens

<400> 5368
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys
        


<210> 5369
<211> 498
<212> PRT
<213> Homo sapiens

<400> 5369
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp
 1               5                  10                  15      
Val Leu Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
            20                  25                  30          
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile
        35                  40                  45              
Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr
65                  70                  75                  80  
Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys
                85                  90                  95      
Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Asp Thr Met Arg Gly Gly Thr Val Ser Leu
        115                 120                 125             
Cys Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
    130                 135                 140                 
Ser Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser
145                 150                 155                 160 
Thr Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe
                165                 170                 175     
Phe Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly
            180                 185                 190         
Val Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu
        195                 200                 205             
Tyr Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala
    210                 215                 220                 
Gly Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln
225                 230                 235                 240 
Asp Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser
                245                 250                 255     
Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu
            260                 265                 270         
Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala
        275                 280                 285             
Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr
    290                 295                 300                 
Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro
305                 310                 315                 320 
Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly
                325                 330                 335     
Cys Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala
            340                 345                 350         
Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly
        355                 360                 365             
Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu
    370                 375                 380                 
Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe
385                 390                 395                 400 
Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu
                405                 410                 415     
Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln
            420                 425                 430         
Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu
        435                 440                 445             
Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala
    450                 455                 460                 
Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys
465                 470                 475                 480 
Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr
                485                 490                 495     
Cys Tyr
        


<210> 5370
<211> 496
<212> PRT
<213> Homo sapiens

<400> 5370
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp
 1               5                  10                  15      
Val Leu Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
            20                  25                  30          
Ser Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile
        35                  40                  45              
Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Ile Ala Asn Thr Tyr Tyr Ser Gly Ile Thr Tyr Tyr
65                  70                  75                  80  
Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys
                85                  90                  95      
Asn Gln Leu Ser Leu Lys Val Arg Ser Val Thr Ala Ala Asp Thr Ala
            100                 105                 110         
Val Tyr Phe Cys Ala Arg His Gly Tyr Ser Arg Ser Gly Arg Thr Gly
        115                 120                 125             
Ala Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
    130                 135                 140                 
Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr Gln
145                 150                 155                 160 
Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro
                165                 170                 175     
Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr
            180                 185                 190         
Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr
        195                 200                 205             
Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys
    210                 215                 220                 
Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val
225                 230                 235                 240 
Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser
                245                 250                 255     
Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu
            260                 265                 270         
His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu
        275                 280                 285             
Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr
    290                 295                 300                 
Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg
305                 310                 315                 320 
Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala
                325                 330                 335     
Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro
            340                 345                 350         
Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr
        355                 360                 365             
Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala
    370                 375                 380                 
Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro
385                 390                 395                 400 
Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg
                405                 410                 415     
Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr
            420                 425                 430         
Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp
        435                 440                 445             
Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro
    450                 455                 460                 
Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr
465                 470                 475                 480 
His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr
                485                 490                 495     


<210> 5371
<211> 499
<212> PRT
<213> Homo sapiens

<400> 5371
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe
        35                  40                  45              
Asp Asp Ser Gly Ala Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Ser Ile Asn Trp Asn Gly Gly Ser Thr Asn Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
                85                  90                  95      
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Pro Thr Lys Tyr Cys Ser Gly Gly Ser Cys
        115                 120                 125             
Leu Gly Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val
    130                 135                 140                 
Ser Ser Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys
145                 150                 155                 160 
Ser Thr Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly
                165                 170                 175     
Phe Phe Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln
            180                 185                 190         
Gly Val Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp
        195                 200                 205             
Leu Tyr Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu
    210                 215                 220                 
Ala Gly Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser
225                 230                 235                 240 
Gln Asp Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro
                245                 250                 255     
Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg
            260                 265                 270         
Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu
        275                 280                 285             
Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val
    290                 295                 300                 
Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro
305                 310                 315                 320 
Pro Asp Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro
                325                 330                 335     
Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala
            340                 345                 350         
Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser
        355                 360                 365             
Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu
    370                 375                 380                 
Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly
385                 390                 395                 400 
Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu
                405                 410                 415     
Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser
            420                 425                 430         
Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala
        435                 440                 445             
Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu
    450                 455                 460                 
Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly
465                 470                 475                 480 
Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly
                485                 490                 495     
Thr Cys Tyr
            


<210> 5372
<211> 497
<212> PRT
<213> Homo sapiens

<400> 5372
Met Asp Trp Thr Trp Arg Leu Leu Phe Leu Val Ala Ala Val Thr Ser
 1               5                  10                  15      
Ala His Ser Gln Glu Gln Leu Glu Gln Ser Gly Ala Glu Val Thr Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Ile Ala Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Met Asn Pro Gln Thr Gly Asn Thr Glu Phe Ala
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Leu Thr Phe Ser Arg Asp Thr Ser Ile Asn
                85                  90                  95      
Thr Ala Tyr Met Val Leu Ser Ser Leu Ser Thr Glu Asp Ser Ala Ile
            100                 105                 110         
Tyr Phe Cys Ala Arg Gly Asn Leu Arg Gly Gly Arg Gly Phe Gly Tyr
        115                 120                 125             
Asn Trp Phe Asp Pro Trp Gly His Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140                 
Ala Ser Pro Thr Asn Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr
145                 150                 155                 160 
Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe
                165                 170                 175     
Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val
            180                 185                 190         
Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr
        195                 200                 205             
Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly
    210                 215                 220                 
Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp
225                 230                 235                 240 
Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro
                245                 250                 255     
Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser
            260                 265                 270         
Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn
        275                 280                 285             
Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe
    290                 295                 300                 
Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu
305                 310                 315                 320 
Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys
                325                 330                 335     
Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr
            340                 345                 350         
Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Pro Lys Ser Gly Asn
        355                 360                 365             
Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu
    370                 375                 380                 
Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser
385                 390                 395                 400 
Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro
                405                 410                 415     
Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly
            420                 425                 430         
Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp
        435                 440                 445             
Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu
    450                 455                 460                 
Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro
465                 470                 475                 480 
Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys
                485                 490                 495     
Tyr
    


<210> 5373
<211> 340
<212> PRT
<213> Homo sapiens

<400> 5373
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr
 1               5                  10                  15      
Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe
            20                  25                  30          
Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val
        35                  40                  45              
Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr
    50                  55                  60                  
Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly
65                  70                  75                  80  
Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp
                85                  90                  95      
Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro
            100                 105                 110         
Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser
        115                 120                 125             
Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly
    130                 135                 140                 
Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly
145                 150                 155                 160 
Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu
                165                 170                 175     
Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr
            180                 185                 190         
Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys
        195                 200                 205             
Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser
    210                 215                 220                 
Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg
225                 230                 235                 240 
Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln
                245                 250                 255     
Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro
            260                 265                 270         
Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala
        275                 280                 285             
Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His
    290                 295                 300                 
Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala
305                 310                 315                 320 
Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp
                325                 330                 335     
Gly Thr Cys Tyr
            340 


<210> 5374
<211> 494
<212> PRT
<213> Homo sapiens

<400> 5374
Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Phe Leu Glu Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe
        35                  40                  45              
Ser Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Ser Ile Ser Ser Arg Ser Asp Tyr Ile Tyr Tyr Arg
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
                85                  90                  95      
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Ser Cys Asn Gly Ala Ile Cys Tyr Gly Phe
        115                 120                 125             
Ser Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro
    130                 135                 140                 
Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr Gln Pro Asp
145                 150                 155                 160 
Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro Gln Glu
                165                 170                 175     
Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr Ala Arg
            180                 185                 190         
Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser
        195                 200                 205             
Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys Ser Val
    210                 215                 220                 
Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val Thr Val
225                 230                 235                 240 
Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro
                245                 250                 255     
Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu His Arg
            260                 265                 270         
Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys
        275                 280                 285             
Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr
    290                 295                 300                 
Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu
305                 310                 315                 320 
Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro
                325                 330                 335     
Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser
            340                 345                 350         
Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg
        355                 360                 365             
Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn
    370                 375                 380                 
Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp
385                 390                 395                 400 
Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys
                405                 410                 415     
Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr
            420                 425                 430         
Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys
        435                 440                 445             
Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala
    450                 455                 460                 
Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val
465                 470                 475                 480 
Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr
                485                 490                 


<210> 5375
<211> 492
<212> PRT
<213> Homo sapiens

<400> 5375
Cys Phe Leu Arg Val Met Asp Leu Met Cys Lys Lys Met Lys His Leu
 1               5                  10                  15      
Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp Val Leu Ser Gln
            20                  25                  30          
Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr
        35                  40                  45              
Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Asn Arg Asn
    50                  55                  60                  
Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp
65                  70                  75                  80  
Ile Gly Ser Ile Tyr Tyr Asn Glu Asn Thr Tyr Tyr Ser Pro Ser Leu
                85                  90                  95      
Lys Ser Arg Leu Thr Ile Phe Val Asp Thr Ser Lys Asn His Phe Ser
            100                 105                 110         
Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
        115                 120                 125             
Val Arg His Val Glu Gly Pro Tyr Gly Trp Phe Asp Pro Trp Gly Gln
    130                 135                 140                 
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Pro Thr Ser Pro Lys Val
145                 150                 155                 160 
Phe Pro Leu Ser Leu Asp Ser Thr Pro Gln Asp Gly Asn Val Val Val
                165                 170                 175     
Ala Cys Leu Val Gln Gly Phe Phe Pro Gln Glu Pro Leu Ser Val Thr
            180                 185                 190         
Trp Ser Glu Ser Gly Gln Asn Val Thr Ala Arg Asn Phe Pro Pro Ser
        195                 200                 205             
Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu Thr Leu
    210                 215                 220                 
Pro Ala Thr Gln Cys Pro Asp Gly Lys Ser Val Thr Cys His Val Lys
225                 230                 235                 240 
His Tyr Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro Val Pro
                245                 250                 255     
Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala
            260                 265                 270         
Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu
        275                 280                 285             
Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser
    290                 295                 300                 
Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly
305                 310                 315                 320 
Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Thr
                325                 330                 335     
His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr
            340                 345                 350         
Pro Leu Thr Ala Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg Pro Glu
        355                 360                 365             
Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu
    370                 375                 380                 
Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu
385                 390                 395                 400 
Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu
                405                 410                 415     
Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala
            420                 425                 430         
Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp
        435                 440                 445             
Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr
    450                 455                 460                 
Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val
465                 470                 475                 480 
Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr
                485                 490         


<210> 5376
<211> 496
<212> PRT
<213> Homo sapiens

<400> 5376
Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Val Thr Gly
 1               5                  10                  15      
Val Gln Ser Gln Val His Leu Val Gln Ser Gly Ala Glu Leu Lys Met
            20                  25                  30          
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Ala Asn Met Phe
        35                  40                  45              
Arg Ser Tyr Ala Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Gln Trp Met Gly Gly Ile Ile Pro Asn Phe Gly Ala Pro Asn Tyr Ala
65                  70                  75                  80  
Gln Asn Phe Gln Asp Arg Val Thr Ile Ser Ala Asp Asp Ser Thr Thr
                85                  90                  95      
Thr Val Tyr Met Glu Leu Thr Ser Leu Thr Phe Glu Asp Thr Ala Phe
            100                 105                 110         
Tyr Tyr Cys Gly Arg Gly Leu Thr Tyr Tyr Gly Ser Gly Ser Tyr Tyr
        115                 120                 125             
Tyr Leu Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
    130                 135                 140                 
Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr Gln
145                 150                 155                 160 
Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro
                165                 170                 175     
Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr
            180                 185                 190         
Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr
        195                 200                 205             
Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys
    210                 215                 220                 
Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val
225                 230                 235                 240 
Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser
                245                 250                 255     
Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu
            260                 265                 270         
His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu
        275                 280                 285             
Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr
    290                 295                 300                 
Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Asp Arg
305                 310                 315                 320 
Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala
                325                 330                 335     
Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro
            340                 345                 350         
Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr
        355                 360                 365             
Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala
    370                 375                 380                 
Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro
385                 390                 395                 400 
Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg
                405                 410                 415     
Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr
            420                 425                 430         
Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp
        435                 440                 445             
Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro
    450                 455                 460                 
Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr
465                 470                 475                 480 
His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr
                485                 490                 495     


<210> 5377
<211> 500
<212> PRT
<213> Homo sapiens

<400> 5377
Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
 1               5                  10                  15      
Ala Gln Ser Gln Val His Leu Val Gln Ser Gly Ala Glu Val Met Ser
            20                  25                  30          
Pro Gly Ala Ser Val Arg Val Ser Cys Lys Thr Ser Gly Tyr Ala Phe
        35                  40                  45              
His Thr Tyr Ser Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile Ser Pro Ser Ser Asp Asn Thr Arg Phe Ala
65                  70                  75                  80  
Lys Lys Phe Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Thr Ser
                85                  90                  95      
Thr Val Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Arg Tyr Cys Ser Tyr Ser Ser Cys Gln Asn Asp
        115                 120                 125             
Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr
    130                 135                 140                 
Val Ser Ser Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu
145                 150                 155                 160 
Cys Ser Thr Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln
                165                 170                 175     
Gly Phe Phe Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly
            180                 185                 190         
Gln Gly Val Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly
        195                 200                 205             
Asp Leu Tyr Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys
    210                 215                 220                 
Leu Ala Gly Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro
225                 230                 235                 240 
Ser Gln Asp Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr
                245                 250                 255     
Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro
            260                 265                 270         
Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser
        275                 280                 285             
Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly
    290                 295                 300                 
Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly
305                 310                 315                 320 
Pro Pro Asp Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu
                325                 330                 335     
Ser Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr
            340                 345                 350         
Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys
        355                 360                 365             
Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser
    370                 375                 380                 
Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg
385                 390                 395                 400 
Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln
                405                 410                 415     
Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro
            420                 425                 430         
Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala
        435                 440                 445             
Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His
    450                 455                 460                 
Glu Ala Leu Pro Leu Ala Phe Thr Gln Glu Thr Ile Asp Arg Leu Ala
465                 470                 475                 480 
Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp
                485                 490                 495     
Gly Thr Cys Tyr
            500 


<210> 5378
<211> 478
<212> PRT
<213> Homo sapiens

<400> 5378
Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp Val
 1               5                  10                  15      
Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro
            20                  25                  30          
Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Gly
        35                  40                  45              
Ser Gly Asp Tyr Phe Trp Ser Trp Ile Arg Gln Ala Pro Gly Arg Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn
65                  70                  75                  80  
Pro Ser Leu Glu Ser Arg Leu Ser Ile Ser Ile Asp Thr Ser Lys Asn
                85                  90                  95      
Gln Phe Ser Leu Arg Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Val
            100                 105                 110         
Tyr Phe Cys Ala Arg Gly Val Gly Leu Gly Thr Ala Phe Asp Ile Trp
        115                 120                 125             
Gly Gln Gly Thr Val Val Thr Val Ser Ser Ala Ser Pro Thr Ser Pro
    130                 135                 140                 
Lys Val Phe Pro Leu Ser Leu Asp Ser Thr Pro Gln Asp Gly Asn Val
145                 150                 155                 160 
Val Val Ala Cys Leu Val Gln Gly Phe Phe Pro Gln Glu Pro Leu Ser
                165                 170                 175     
Val Thr Trp Ser Glu Ser Gly Gln Asn Val Thr Ala Arg Asn Phe Pro
            180                 185                 190         
Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu
        195                 200                 205             
Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly Lys Ser Val Thr Cys His
    210                 215                 220                 
Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro
225                 230                 235                 240 
Val Pro Pro Pro Pro Pro Cys Cys His Pro Arg Leu Ser Leu His Arg
                245                 250                 255     
Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys
            260                 265                 270         
Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr
        275                 280                 285             
Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu
    290                 295                 300                 
Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Gln Pro
305                 310                 315                 320 
Trp Asn His Gly Glu Thr Phe Thr Cys Thr Ala Ala His Pro Glu Leu
                325                 330                 335     
Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys Ser Gly Asn Thr Phe Arg
            340                 345                 350         
Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn
        355                 360                 365             
Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp
    370                 375                 380                 
Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys
385                 390                 395                 400 
Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr
                405                 410                 415     
Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys
            420                 425                 430         
Gly Asp Thr Phe Ser Cys Met Val Ser His Glu Ala Leu Pro Leu Ala
        435                 440                 445             
Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val
    450                 455                 460                 
Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr
465                 470                 475             


<210> 5379
<211> 698
<212> PRT
<213> Homo sapiens

<400> 5379
Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu
 1               5                  10                  15      
Cys Leu Ala Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu
            20                  25                  30          
His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val
        35                  40                  45              
Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr
    50                  55                  60                  
Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr
65                  70                  75                  80  
Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu
                85                  90                  95      
Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr
            100                 105                 110         
Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met
        115                 120                 125             
Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser
    130                 135                 140                 
Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu
145                 150                 155                 160 
Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser
                165                 170                 175     
Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu
            180                 185                 190         
Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser
        195                 200                 205             
Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val
    210                 215                 220                 
Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp
225                 230                 235                 240 
Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu
                245                 250                 255     
Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala
            260                 265                 270         
Arg Ser Met Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln
        275                 280                 285             
Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe
    290                 295                 300                 
Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly
305                 310                 315                 320 
Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr
                325                 330                 335     
Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu
            340                 345                 350         
Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His
        355                 360                 365             
His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys
    370                 375                 380                 
Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile
385                 390                 395                 400 
Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr
                405                 410                 415     
Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn
            420                 425                 430         
Lys Ser Asp Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Val
        435                 440                 445             
Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys
    450                 455                 460                 
Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn
465                 470                 475                 480 
Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp
                485                 490                 495     
Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser
            500                 505                 510         
Leu Cys Lys Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn
        515                 520                 525             
Asn Lys Glu Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val
    530                 535                 540                 
Glu Lys Gly Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn
545                 550                 555                 560 
Thr Gly Gly Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys
                565                 570                 575     
Asp Tyr Glu Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu
            580                 585                 590         
Tyr Ala Asn Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr
        595                 600                 605             
Arg Lys Asp Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln
    610                 615                 620                 
His Leu Phe Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu
625                 630                 635                 640 
Phe Arg Ser Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys
                645                 650                 655     
Leu Ala Lys Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu
            660                 665                 670         
Glu Tyr Val Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser
        675                 680                 685             
Leu Leu Glu Ala Cys Thr Phe Arg Arg Pro
    690                 695             


<210> 5380
<211> 1664
<212> PRT
<213> Homo sapiens

<400> 5380
Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His
 1               5                  10                  15      
Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn
            20                  25                  30          
Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp
        35                  40                  45              
Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly
    50                  55                  60                  
Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr
65                  70                  75                  80  
Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe
                85                  90                  95      
Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe
            100                 105                 110         
Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly
        115                 120                 125             
Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr
    130                 135                 140                 
Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly
145                 150                 155                 160 
Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys
                165                 170                 175     
Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser
            180                 185                 190         
Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala
        195                 200                 205             
Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val
    210                 215                 220                 
Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu
225                 230                 235                 240 
Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr
                245                 250                 255     
Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile
            260                 265                 270         
Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu
        275                 280                 285             
Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg
    290                 295                 300                 
Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val
305                 310                 315                 320 
Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser
                325                 330                 335     
Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro
            340                 345                 350         
Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met
        355                 360                 365             
Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala
    370                 375                 380                 
Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu
385                 390                 395                 400 
Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser
                405                 410                 415     
Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser
            420                 425                 430         
Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr
        435                 440                 445             
Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu
    450                 455                 460                 
Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp
465                 470                 475                 480 
Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn
                485                 490                 495     
Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln
            500                 505                 510         
Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser
        515                 520                 525             
Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg
    530                 535                 540                 
Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val
545                 550                 555                 560 
Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val
                565                 570                 575     
Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg
            580                 585                 590         
Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys
        595                 600                 605             
Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp
    610                 615                 620                 
Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser
625                 630                 635                 640 
Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln
                645                 650                 655     
Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser
            660                 665                 670         
Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys
        675                 680                 685             
Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg
    690                 695                 700                 
Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys
705                 710                 715                 720 
Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg
                725                 730                 735     
Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp
            740                 745                 750         
Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro
        755                 760                 765             
Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn
    770                 775                 780                 
Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr
785                 790                 795                 800 
Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys
                805                 810                 815     
Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp
            820                 825                 830         
Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg
        835                 840                 845             
Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val
    850                 855                 860                 
Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg
865                 870                 875                 880 
Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val
                885                 890                 895     
Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val
            900                 905                 910         
Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser
        915                 920                 925             
Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val
    930                 935                 940                 
Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu
945                 950                 955                 960 
Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser
                965                 970                 975     
Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu
            980                 985                 990         
Asp Ala Val Asp Ala Glu Arg Leu Lys His Leu Ile Val Thr Pro Ser
        995                 1000                1005            
Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro Thr Val Ile Ala
    1010                1015                1020                
Val His Tyr Leu Asp Glu Thr Glu Gln Trp Glu Lys Phe Gly Leu Glu
1025                1030                1035                1040
Lys Arg Gln Gly Ala Leu Glu Leu Ile Lys Lys Gly Tyr Thr Gln Gln
                1045                1050                1055    
Leu Ala Phe Arg Gln Pro Ser Ser Ala Phe Ala Ala Phe Val Lys Arg
            1060                1065                1070        
Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys Val Phe Ser Leu
        1075                1080                1085            
Ala Val Asn Leu Ile Ala Ile Asp Ser Gln Val Leu Cys Gly Ala Val
    1090                1095                1100                
Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro Asp Gly Val Phe Gln Glu
1105                1110                1115                1120
Asp Ala Pro Val Ile His Gln Glu Met Ile Gly Gly Leu Arg Asn Asn
                1125                1130                1135    
Asn Glu Lys Asp Met Ala Leu Thr Ala Phe Val Leu Ile Ser Leu Gln
            1140                1145                1150        
Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser Leu Pro Gly Ser
        1155                1160                1165            
Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr Met Asn Leu Gln
    1170                1175                1180                
Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu Ala Gln Met Gly
1185                1190                1195                1200
Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Thr Thr Ala Lys Asp
                1205                1210                1215    
Lys Asn Arg Trp Glu Asp Pro Gly Lys Gln Leu Tyr Asn Val Glu Ala
            1220                1225                1230        
Thr Ser Tyr Ala Leu Leu Ala Leu Leu Gln Leu Lys Asp Phe Asp Phe
        1235                1240                1245            
Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg Tyr Tyr Gly Gly
    1250                1255                1260                
Gly Tyr Gly Ser Thr Gln Ala Ser Thr Phe Met Val Phe Gln Ala Leu
1265                1270                1275                1280
Ala Gln Tyr Gln Lys Asp Ala Pro Asp His Gln Glu Leu Asn Leu Asp
                1285                1290                1295    
Val Ser Leu Gln Leu Pro Ser Arg Ser Ser Lys Ile Thr His Arg Ile
            1300                1305                1310        
His Trp Glu Ser Ala Ser Leu Leu Arg Ser Glu Glu Thr Lys Glu Asn
        1315                1320                1325            
Glu Gly Phe Thr Val Thr Ala Glu Gly Lys Gly Gln Gly Thr Leu Ser
    1330                1335                1340                
Val Val Thr Met Tyr His Ala Lys Ala Lys Asp Gln Leu Thr Cys Asn
1345                1350                1355                1360
Lys Phe Asp Leu Lys Val Thr Ile Lys Pro Ala Pro Glu Thr Glu Lys
                1365                1370                1375    
Arg Pro Gln Asp Ala Lys Asn Thr Met Ile Leu Glu Ile Cys Thr Arg
            1380                1385                1390        
Tyr Arg Gly Asp Gln Asp Ala Thr Met Ser Ile Leu Asp Ile Ser Met
        1395                1400                1405            
Met Thr Gly Phe Ala Pro Asp Thr Asp Asp Leu Lys Gln Leu Ala Asn
    1410                1415                1420                
Gly Val Asp Arg Tyr Ile Ser Lys Tyr Glu Leu Asp Lys Ala Phe Ser
1425                1430                1435                1440
Asp Arg Asn Thr Leu Ile Ile Tyr Leu Asp Lys Val Ser His Ser Glu
                1445                1450                1455    
Asp Asp Cys Leu Ala Phe Lys Val His Gln Tyr Phe Asn Val Glu Leu
            1460                1465                1470        
Ile Gln Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn Leu Glu Glu
        1475                1480                1485            
Ser Cys Thr Arg Phe Tyr His Pro Glu Lys Glu Asp Gly Lys Leu Asn
    1490                1495                1500                
Lys Leu Cys Arg Asp Glu Leu Cys Arg Cys Ala Glu Glu Asn Cys Phe
1505                1510                1515                1520
Ile Gln Lys Ser Asp Asp Lys Val Thr Leu Glu Glu Arg Leu Asp Lys
                1525                1530                1535    
Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Thr Arg Leu Val Lys
            1540                1545                1550        
Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala Ile Glu Gln
        1555                1560                1565            
Thr Ile Lys Ser Gly Ser Asp Glu Val Gln Val Gly Gln Gln Arg Thr
    1570                1575                1580                
Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala Leu Lys Leu Glu Glu Lys
1585                1590                1595                1600
Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp Gly Glu Lys
                1605                1610                1615    
Pro Asn Leu Ser Tyr Ile Ile Gly Lys Asp Thr Trp Val Glu His Trp
            1620                1625                1630        
Pro Glu Glu Asp Glu Cys Gln Asp Glu Glu Asn Gln Lys Gln Cys Gln
        1635                1640                1645            
Asp Leu Gly Ala Phe Thr Glu Ser Met Val Val Phe Gly Cys Pro Asn
    1650                1655                1660                


<210> 5381
<211> 1474
<212> PRT
<213> Homo sapiens

<400> 5381
Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu
 1               5                  10                  15      
Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met
            20                  25                  30          
Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys
        35                  40                  45              
Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu
    50                  55                  60                  
Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu
65                  70                  75                  80  
Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser
                85                  90                  95      
Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln
            100                 105                 110         
Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu
        115                 120                 125             
Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val
    130                 135                 140                 
Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu
145                 150                 155                 160 
Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala
                165                 170                 175     
Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe
            180                 185                 190         
Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln
        195                 200                 205             
Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe
    210                 215                 220                 
Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr
225                 230                 235                 240 
Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr
                245                 250                 255     
Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr
            260                 265                 270         
Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu
        275                 280                 285             
Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val
    290                 295                 300                 
Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu
305                 310                 315                 320 
His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr
                325                 330                 335     
Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe
            340                 345                 350         
Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln
        355                 360                 365             
Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile
    370                 375                 380                 
Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp
385                 390                 395                 400 
Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly
                405                 410                 415     
Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr
            420                 425                 430         
Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala
        435                 440                 445             
Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met
    450                 455                 460                 
Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr
465                 470                 475                 480 
Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr
                485                 490                 495     
Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly
            500                 505                 510         
Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile
        515                 520                 525             
Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala
    530                 535                 540                 
Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val
545                 550                 555                 560 
Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln
                565                 570                 575     
Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln
            580                 585                 590         
Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys
        595                 600                 605             
Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu
    610                 615                 620                 
Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu
625                 630                 635                 640 
Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr
                645                 650                 655     
Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp
            660                 665                 670         
Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met
        675                 680                 685             
Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg
    690                 695                 700                 
Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu
705                 710                 715                 720 
Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro
                725                 730                 735     
Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala
            740                 745                 750         
Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly
        755                 760                 765             
Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala
    770                 775                 780                 
Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr
785                 790                 795                 800 
Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn
                805                 810                 815     
Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro
            820                 825                 830         
Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile
        835                 840                 845             
Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser
    850                 855                 860                 
Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln
865                 870                 875                 880 
Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys
                885                 890                 895     
Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys
            900                 905                 910         
Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser
        915                 920                 925             
Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala
    930                 935                 940                 
Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln
945                 950                 955                 960 
Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn
                965                 970                 975     
Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu
            980                 985                 990         
Thr Gln Gln Leu Thr Pro Glu Val Lys Ser Lys Ala Ile Gly Tyr Leu
        995                 1000                1005            
Asn Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Tyr Asp Gly Ser
    1010                1015                1020                
Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly Asn Thr Trp
1025                1030                1035                1040
Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln Ala Arg Ala Tyr Ile
                1045                1050                1055    
Phe Ile Asp Glu Ala His Ile Thr Gln Ala Leu Ile Trp Leu Ser Gln
            1060                1065                1070        
Arg Gln Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu Asn
        1075                1080                1085            
Asn Ala Ile Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala Tyr
    1090                1095                1100                
Ile Thr Ile Ala Leu Leu Glu Ile Pro Leu Thr Val Thr His Pro Val
1105                1110                1115                1120
Val Arg Asn Ala Leu Phe Cys Leu Glu Ser Ala Trp Lys Thr Ala Gln
                1125                1130                1135    
Glu Gly Asp His Gly Ser His Val Tyr Thr Lys Ala Leu Leu Ala Tyr
            1140                1145                1150        
Ala Phe Ala Leu Ala Gly Asn Gln Asp Lys Arg Lys Glu Val Leu Lys
        1155                1160                1165            
Ser Leu Asn Glu Glu Ala Val Lys Lys Asp Asn Ser Val His Trp Glu
    1170                1175                1180                
Arg Pro Gln Lys Pro Lys Ala Pro Val Gly His Phe Tyr Glu Pro Gln
1185                1190                1195                1200
Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu Leu Ala Tyr
                1205                1210                1215    
Leu Thr Ala Gln Pro Ala Pro Thr Ser Glu Asp Leu Thr Ser Ala Thr
            1220                1225                1230        
Asn Ile Val Lys Trp Ile Thr Lys Gln Gln Asn Ala Gln Gly Gly Phe
        1235                1240                1245            
Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys Tyr
    1250                1255                1260                
Gly Ala Ala Thr Phe Thr Arg Thr Gly Lys Ala Ala Gln Val Thr Ile
1265                1270                1275                1280
Gln Ser Ser Gly Thr Phe Ser Ser Lys Phe Gln Val Asp Asn Asn Asn
                1285                1290                1295    
Arg Leu Leu Leu Gln Gln Val Ser Leu Pro Glu Leu Pro Gly Glu Tyr
            1300                1305                1310        
Ser Met Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser Leu
        1315                1320                1325            
Lys Tyr Asn Ile Leu Pro Glu Lys Glu Glu Phe Pro Phe Ala Leu Gly
    1330                1335                1340                
Val Gln Thr Leu Pro Gln Thr Cys Asp Glu Pro Lys Ala His Thr Ser
1345                1350                1355                1360
Phe Gln Ile Ser Leu Ser Val Ser Tyr Thr Gly Ser Arg Ser Ala Ser
                1365                1370                1375    
Asn Met Ala Ile Val Asp Val Lys Met Val Ser Gly Phe Ile Pro Leu
            1380                1385                1390        
Lys Pro Thr Val Lys Met Leu Glu Arg Ser Asn His Val Ser Arg Thr
        1395                1400                1405            
Glu Val Ser Ser Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn
    1410                1415                1420                
Gln Thr Leu Ser Leu Phe Phe Thr Val Leu Gln Asp Val Pro Val Arg
1425                1430                1435                1440
Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr Glu Thr Asp
                1445                1450                1455    
Glu Phe Ala Ile Ala Glu Tyr Asn Ala Pro Cys Ser Lys Asp Leu Gly
            1460                1465                1470        
Asn Ala
        


<210> 5382
<211> 201
<212> PRT
<213> Homo sapiens

<400> 5382
Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu
 1               5                  10                  15      
Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr
            20                  25                  30          
Asn Ala Thr Leu Asp Gln Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser
        35                  40                  45              
Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala
    50                  55                  60                  
Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu
65                  70                  75                  80  
Arg Glu Tyr Gln Thr Arg Gln Asp Gln Cys Ile Tyr Asn Thr Thr Tyr
                85                  90                  95      
Leu Asn Val Gln Arg Glu Asn Gly Thr Ile Ser Arg Tyr Val Gly Gly
            100                 105                 110         
Gln Glu His Phe Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr
        115                 120                 125             
Met Leu Ala Phe Asp Val Asn Asp Glu Lys Asn Trp Gly Leu Ser Val
    130                 135                 140                 
Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr
145                 150                 155                 160 
Glu Ala Leu Asp Cys Leu Arg Ile Pro Lys Ser Asp Val Val Tyr Thr
                165                 170                 175     
Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys
            180                 185                 190         
Glu Arg Lys Gln Glu Glu Gly Glu Ser
        195                 200     


<210> 5383
<211> 521
<212> PRT
<213> Homo sapiens

<400> 5383
Met Glu Phe Gly Leu Ser Trp Val Leu Leu Val Val Phe Leu Gln Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val
        35                  40                  45              
Ser Asp His Tyr Val Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Pro
    50                  55                  60                  
Glu Trp Val Gly Cys Phe Arg Ser Lys Ala His Lys Ser Thr Thr Glu
65                  70                  75                  80  
Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Leu Arg Asp Asp Ser
                85                  90                  95      
Lys Asn Ser Val His Leu Gln Met Asn Ser Leu Lys Thr Asp Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Val Arg Asp Leu Glu Gly Ala Gly Lys Tyr Asp
        115                 120                 125             
Trp Tyr Phe Asp Ile Trp Gly Arg Gly Ile Leu Val Thr Val Ser Ser
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
        195                 200                 205             
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
    210                 215                 220                 
Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
225                 230                 235                 240 
Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro
                245                 250                 255     
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg
            260                 265                 270         
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys
        275                 280                 285             
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
    290                 295                 300                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
305                 310                 315                 320 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                325                 330                 335     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr
            340                 345                 350         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        355                 360                 365             
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
    370                 375                 380                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
385                 390                 395                 400 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
                405                 410                 415     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
            420                 425                 430         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        435                 440                 445             
Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn
    450                 455                 460                 
Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
465                 470                 475                 480 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile
                485                 490                 495     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln
            500                 505                 510         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        515                 520     


<210> 5384
<211> 509
<212> PRT
<213> Homo sapiens

<400> 5384
Leu Trp Leu Trp Gly Arg Glu Trp Ala Lys Val Thr Gln Val Ala Pro
 1               5                  10                  15      
Ala Arg Arg Thr Pro Asn Ala Arg Glu Pro Arg His Trp Thr Leu Pro
            20                  25                  30          
Gly Pro Ser Trp Ile Asp Lys Asn Gln Gly Ala Ser Ala Pro Trp Ala
        35                  40                  45              
Gln Leu Cys Pro Thr Pro Gln Ser His Gly Ala Ile Ser Leu Ala Ala
    50                  55                  60                  
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser
65                  70                  75                  80  
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                85                  90                  95      
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
            100                 105                 110         
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
        115                 120                 125             
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
    130                 135                 140                 
Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
145                 150                 155                 160 
Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg
                165                 170                 175     
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys
            180                 185                 190         
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
        195                 200                 205             
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala
    210                 215                 220                 
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
305                 310                 315                 320 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu
        435                 440                 445             
Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe
    450                 455                 460                 
Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val Thr Phe
465                 470                 475                 480 
Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr
                485                 490                 495     
Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala
            500                 505                 


<210> 5385
<211> 420
<212> PRT
<213> Homo sapiens

<400> 5385
Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly Phe Cys Pro
 1               5                  10                  15      
Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu Asn Leu Thr
            20                  25                  30          
Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly Leu Ala Ser
        35                  40                  45              
Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu Val Leu Lys
    50                  55                  60                  
Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile Ser Thr Ala
65                  70                  75                  80  
Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu Thr Glu Ile
                85                  90                  95      
Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu Ala Glu Ile
            100                 105                 110         
His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln Ser Ser Asp
        115                 120                 125             
Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys Glu Gln Leu
    130                 135                 140                 
Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu Tyr Gly Ser
145                 150                 155                 160 
Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala Lys Lys Leu
                165                 170                 175     
Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile Thr Asp Leu
            180                 185                 190         
Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val Asn Tyr Ile
        195                 200                 205             
Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln Asp Thr His
    210                 215                 220                 
Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met Val Pro Met
225                 230                 235                 240 
Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp Glu Glu Leu
                245                 250                 255     
Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala Ser Ala Leu
            260                 265                 270         
Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu Ala Met Leu
        275                 280                 285             
Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu Phe Arg Glu
    290                 295                 300                 
Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg Asp Tyr Asn
305                 310                 315                 320 
Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala Phe Thr Ser
                325                 330                 335     
Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu Ala Val Ser
            340                 345                 350         
Gln Val Thr His Lys Ala Met Met Thr Leu Asp Glu Arg Gly Ser Glu
        355                 360                 365             
Ala Ala Ala Ala Thr Ser Ile Gln Leu Thr Pro Gly Pro Arg Pro Asp
    370                 375                 380                 
Leu Asp Phe Pro Pro Thr Leu Gly Thr Glu Phe Ser Arg Pro Phe Leu
385                 390                 395                 400 
Val Met Thr Phe His Thr Glu Thr Gly Ser Met Leu Phe Leu Glu Lys
                405                 410                 415     
Ile Val Asn Pro
            420 


<210> 5386
<211> 367
<212> PRT
<213> Homo sapiens

<400> 5386
Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys
 1               5                  10                  15      
His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys
            20                  25                  30          
Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile
        35                  40                  45              
Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp
    50                  55                  60                  
Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile
65                  70                  75                  80  
Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro
                85                  90                  95      
Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly
            100                 105                 110         
Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val
        115                 120                 125             
Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys
    130                 135                 140                 
Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val
145                 150                 155                 160 
Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn
                165                 170                 175     
Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro
            180                 185                 190         
Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys
        195                 200                 205             
Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu
    210                 215                 220                 
Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly
225                 230                 235                 240 
Ala Glu Val Ala Val Thr Cys Thr Val Phe Gln Thr Gln Pro Val Thr
                245                 250                 255     
Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val
            260                 265                 270         
Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu
        275                 280                 285             
Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro
    290                 295                 300                 
Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe
305                 310                 315                 320 
Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro
                325                 330                 335     
Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly
            340                 345                 350         
Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val
        355                 360                 365         


<210> 5387
<211> 201
<212> PRT
<213> Homo sapiens

<400> 5387
Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu
 1               5                  10                  15      
Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr
            20                  25                  30          
Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser
        35                  40                  45              
Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala
    50                  55                  60                  
Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu
65                  70                  75                  80  
Arg Glu Tyr Gln Thr Arg Gln Asn Gln Cys Phe Tyr Asn Ser Ser Tyr
                85                  90                  95      
Leu Asn Val Gln Arg Glu Asn Gly Thr Val Ser Arg Tyr Glu Gly Gly
            100                 105                 110         
Arg Glu His Val Ala His Leu Leu Phe Leu Arg Asp Thr Lys Thr Leu
        115                 120                 125             
Met Phe Gly Ser Tyr Leu Asp Asp Glu Lys Asn Trp Gly Leu Ser Phe
    130                 135                 140                 
Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr
145                 150                 155                 160 
Glu Ala Leu Asp Cys Leu Cys Ile Pro Arg Ser Asp Val Met Tyr Thr
                165                 170                 175     
Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys
            180                 185                 190         
Glu Arg Lys Gln Glu Glu Gly Glu Ser
        195                 200     


<210> 5388
<211> 764
<212> PRT
<213> Homo sapiens

<400> 5388
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu
 1               5                  10                  15      
Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg
            20                  25                  30          
Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser
        35                  40                  45              
Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser
    50                  55                  60                  
Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly
65                  70                  75                  80  
Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala
                85                  90                  95      
Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly
            100                 105                 110         
Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser
        115                 120                 125             
Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr
    130                 135                 140                 
Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn
145                 150                 155                 160 
Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys
                165                 170                 175     
Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser
            180                 185                 190         
Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly
        195                 200                 205             
Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr
    210                 215                 220                 
Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu
225                 230                 235                 240 
Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln
                245                 250                 255     
Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr
            260                 265                 270         
Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly
        275                 280                 285             
Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly
    290                 295                 300                 
Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile
305                 310                 315                 320 
Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr
                325                 330                 335     
Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly
            340                 345                 350         
Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp
        355                 360                 365             
Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile
    370                 375                 380                 
Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr
385                 390                 395                 400 
Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys
                405                 410                 415     
Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro
            420                 425                 430         
Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn
        435                 440                 445             
Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val
    450                 455                 460                 
Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met
465                 470                 475                 480 
Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln
                485                 490                 495     
Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met
            500                 505                 510         
Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe
        515                 520                 525             
Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu
    530                 535                 540                 
Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn
545                 550                 555                 560 
Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp
                565                 570                 575     
Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile
            580                 585                 590         
Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg
        595                 600                 605             
Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro
    610                 615                 620                 
Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu
625                 630                 635                 640 
Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys
                645                 650                 655     
Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile
            660                 665                 670         
Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro
        675                 680                 685             
Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile
    690                 695                 700                 
Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly
705                 710                 715                 720 
Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala
                725                 730                 735     
His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu
            740                 745                 750         
Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu
        755                 760                 


<210> 5389
<211> 621
<212> PRT
<213> Homo sapiens

<400> 5389
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu
 1               5                  10                  15      
Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg
            20                  25                  30          
Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser
        35                  40                  45              
Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser
    50                  55                  60                  
Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly
65                  70                  75                  80  
Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala
                85                  90                  95      
Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly
            100                 105                 110         
Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser
        115                 120                 125             
Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr
    130                 135                 140                 
Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn
145                 150                 155                 160 
Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys
                165                 170                 175     
Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser
            180                 185                 190         
Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly
        195                 200                 205             
Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr
    210                 215                 220                 
Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu
225                 230                 235                 240 
Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln
                245                 250                 255     
Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr
            260                 265                 270         
Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly
        275                 280                 285             
Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly
    290                 295                 300                 
Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile
305                 310                 315                 320 
Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr
                325                 330                 335     
Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly
            340                 345                 350         
Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp
        355                 360                 365             
Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile
    370                 375                 380                 
Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr
385                 390                 395                 400 
Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys
                405                 410                 415     
Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro
            420                 425                 430         
Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn
        435                 440                 445             
Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val
    450                 455                 460                 
Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met
465                 470                 475                 480 
Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln
                485                 490                 495     
Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met
            500                 505                 510         
Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe
        515                 520                 525             
Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Lys Asp
    530                 535                 540                 
Ala Thr Glu Gly Pro Gly Leu His Leu Cys Ser Pro Gly Asn Thr Ser
545                 550                 555                 560 
His Phe Leu Gln Ile Leu His Ser Thr His Pro Gln Cys Ser Pro Ile
                565                 570                 575     
Pro Cys Thr Pro Asp Gln Ser Gly Met Gly Glu Asp Val Lys Leu Gly
            580                 585                 590         
Met Thr Arg Gly Gln Arg Gln Glu Ala Ala His Lys Glu Val Val Pro
        595                 600                 605             
Thr Leu Leu Leu Gln Glu Gly Arg Ser Gly Thr Trp Arg
    610                 615                 620     


<210> 5390
<211> 566
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 505
<223> Xaa = Any Amino Acid

<400> 5390
Met Thr Glu Arg Leu Leu Ile Lys Ala Leu Ser Gly Gly Lys Asn Thr
 1               5                  10                  15      
Lys Ile Ile Thr Leu Asn Gly Lys Lys Met Thr Lys Met Pro Ser Ala
            20                  25                  30          
Leu Gly Lys Leu Pro Gly Leu Lys Thr Leu Val Leu Gln Asn Asn Leu
        35                  40                  45              
Ile Pro Lys Val Cys Pro Glu Leu Cys Asn Leu Thr Gln Leu Thr Thr
    50                  55                  60                  
Leu Asn Leu Gly Asn Asn Leu Leu Glu Glu Val Pro Glu Glu Met Lys
65                  70                  75                  80  
Tyr Leu Thr Ser Leu Lys Asn Leu His Leu Ser Gly Asn Arg Ile Cys
                85                  90                  95      
Arg Phe Ala Pro Gly Ala Cys Gly Val Pro Pro Ser Ala Ser His Val
            100                 105                 110         
Ala Pro Thr Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val
        115                 120                 125             
Gly Pro Thr Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser
    130                 135                 140                 
Ala Val Asp Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met
145                 150                 155                 160 
Lys Ile Cys Lys Lys Gly Ser Leu His Ala Asn Trp Arg Gln Lys Asp
                165                 170                 175     
Val Asp Lys Glu Phe Tyr Leu Phe Pro Ile Val Phe Asn Glu Asn Glu
            180                 185                 190         
Gly Leu Leu Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp
        195                 200                 205             
Gln Val Asp Lys Ala Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His
    210                 215                 220                 
Trp Thr Phe Asn Val Asp Ala Leu Gln Leu Ala Asp His Tyr Thr Gly
225                 230                 235                 240 
Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Trp Gln Ser Glu
                245                 250                 255     
Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile Ala Ala Val
            260                 265                 270         
Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu Lys Glu Leu
        275                 280                 285             
His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu Asp Lys Gly
    290                 295                 300                 
Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr Arg Gln Tyr
305                 310                 315                 320 
Thr Asp Cys Thr Phe Arg Ile Pro Val Glu Arg Lys Ala Glu Glu Glu
                325                 330                 335     
His Leu Gly Ile Leu Gly Leu Gln Leu His Ala Asp Val Gly Asp Lys
            340                 345                 350         
Val Lys Ile Ile Phe Lys Asn Met Thr Thr Arg Pro Tyr Ser Ile His
        355                 360                 365             
Ala His Gly Val Gln Thr Glu Ser Ser Thr Phe Ile Pro Ala Leu Pro
    370                 375                 380                 
Gly Glu Thr Leu Thr Tyr Leu Trp Lys Ile Pro Glu Arg Ser Gly Ala
385                 390                 395                 400 
Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr Ser Thr Val
                405                 410                 415     
Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro Leu Ile Val
            420                 425                 430         
Cys Arg Arg His Tyr Leu Lys Val Phe Asn Pro Arg Lys Lys Leu Glu
        435                 440                 445             
Phe Thr Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser Trp Tyr Leu
    450                 455                 460                 
Asp Asp Asn Ile Lys Thr Asn Ser Asp His Pro Lys Lys Ala Ser Gln
465                 470                 475                 480 
Cys Thr Trp Glu Met Lys Pro Met Gly Asp Glu Ile Asp Leu His Thr
                485                 490                 495     
Val His Phe His Gly His Ser Phe Xaa Tyr Lys His Arg Gly Val Tyr
            500                 505                 510         
Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr Gln Thr Leu Glu
        515                 520                 525             
Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys His Val Thr
    530                 535                 540                 
Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Ile Val Leu Gln Asn
545                 550                 555                 560 
Glu Asp Thr Lys Ser Gly
                565     


<210> 5391
<211> 1065
<212> PRT
<213> Homo sapiens

<400> 5391
Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro
 1               5                  10                  15      
Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr
            20                  25                  30          
Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp
        35                  40                  45              
Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly
    50                  55                  60                  
Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe
65                  70                  75                  80  
Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile
                85                  90                  95      
Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu
            100                 105                 110         
Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys
        115                 120                 125             
Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg
    130                 135                 140                 
Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu
145                 150                 155                 160 
Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr
                165                 170                 175     
Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly
            180                 185                 190         
Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu
        195                 200                 205             
Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val
    210                 215                 220                 
Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys
225                 230                 235                 240 
Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser
                245                 250                 255     
Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly
            260                 265                 270         
Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met
        275                 280                 285             
Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu
    290                 295                 300                 
Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr
305                 310                 315                 320 
Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu
                325                 330                 335     
Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe
            340                 345                 350         
Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly
        355                 360                 365             
Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn
    370                 375                 380                 
Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala
385                 390                 395                 400 
Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile
                405                 410                 415     
Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser
            420                 425                 430         
Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile
        435                 440                 445             
Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr
    450                 455                 460                 
Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val
465                 470                 475                 480 
Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn
                485                 490                 495     
Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr
            500                 505                 510         
Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr
        515                 520                 525             
Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp
    530                 535                 540                 
Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys
545                 550                 555                 560 
Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys
                565                 570                 575     
Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu
            580                 585                 590         
Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp
        595                 600                 605             
Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn
    610                 615                 620                 
Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp
625                 630                 635                 640 
Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His
                645                 650                 655     
Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg
            660                 665                 670         
Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp
        675                 680                 685             
Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His
    690                 695                 700                 
Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg
705                 710                 715                 720 
Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile
                725                 730                 735     
Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu
            740                 745                 750         
Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu
        755                 760                 765             
Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr
    770                 775                 780                 
Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala
785                 790                 795                 800 
Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val
                805                 810                 815     
Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr
            820                 825                 830         
Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro
        835                 840                 845             
Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg
    850                 855                 860                 
Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr
865                 870                 875                 880 
Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro
                885                 890                 895     
Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg
            900                 905                 910         
Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser
        915                 920                 925             
Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys
    930                 935                 940                 
Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala
945                 950                 955                 960 
Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val
                965                 970                 975     
Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp
            980                 985                 990         
Leu His Thr Val His Phe His Gly His Ser Phe Gln Tyr Lys His Arg
        995                 1000                1005            
Gly Val Tyr Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr Gln
    1010                1015                1020                
Thr Leu Glu Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys
1025                1030                1035                1040
His Val Thr Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val
                1045                1050                1055    
Leu Gln Asn Glu Asp Thr Lys Ser Gly
            1060                1065


<210> 5392
<211> 644
<212> PRT
<213> Homo sapiens

<400> 5392
Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser
 1               5                  10                  15      
Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp
            20                  25                  30          
Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn
        35                  40                  45              
Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys
    50                  55                  60                  
Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu
65                  70                  75                  80  
Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr
                85                  90                  95      
Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly
            100                 105                 110         
Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile
        115                 120                 125             
Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly
    130                 135                 140                 
Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu
145                 150                 155                 160 
Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu
                165                 170                 175     
Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly
            180                 185                 190         
Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys
        195                 200                 205             
Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly
    210                 215                 220                 
Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg
225                 230                 235                 240 
Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe
                245                 250                 255     
Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro
            260                 265                 270         
Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys
        275                 280                 285             
Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val
    290                 295                 300                 
Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp
305                 310                 315                 320 
Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu
                325                 330                 335     
Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn
            340                 345                 350         
Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val
        355                 360                 365             
Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly
    370                 375                 380                 
Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr
385                 390                 395                 400 
Thr Val Ser Pro Pro His Thr Ser Met Ala Pro Ala Gln Asp Glu Glu
                405                 410                 415     
Arg Asp Ser Gly Lys Glu Gln Gly His Thr Arg Arg His Asp Trp Gly
            420                 425                 430         
His Glu Lys Gln Arg Lys His Asn Leu Gly His Gly His Lys His Glu
        435                 440                 445             
Arg Asp Gln Gly His Gly His Gln Arg Gly His Gly Leu Gly His Gly
    450                 455                 460                 
His Glu Gln Gln His Gly Leu Gly His Gly His Lys Phe Lys Leu Asp
465                 470                 475                 480 
Asp Asp Leu Glu His Gln Gly Gly His Val Leu Asp His Gly His Lys
                485                 490                 495     
His Lys His Gly His Gly His Gly Lys His Lys Asn Lys Gly Lys Lys
            500                 505                 510         
Asn Gly Lys His Asn Gly Trp Lys Thr Glu His Leu Ala Ser Ser Ser
        515                 520                 525             
Glu Asp Ser Thr Thr Pro Ser Ala Gln Thr Gln Glu Lys Thr Glu Gly
    530                 535                 540                 
Pro Thr Pro Ile Pro Ser Leu Ala Lys Pro Gly Val Thr Val Thr Phe
545                 550                 555                 560 
Ser Asp Phe Gln Asp Ser Asp Leu Ile Ala Thr Met Met Pro Pro Ile
                565                 570                 575     
Ser Pro Ala Pro Ile Gln Ser Asp Asp Asp Trp Ile Pro Asp Ile Gln
            580                 585                 590         
Thr Asp Pro Asn Gly Leu Ser Phe Asn Pro Ile Ser Asp Phe Pro Asp
        595                 600                 605             
Thr Thr Ser Pro Lys Cys Pro Gly Arg Pro Trp Lys Ser Val Ser Glu
    610                 615                 620                 
Ile Asn Pro Thr Thr Gln Met Lys Glu Ser Tyr Tyr Phe Asp Leu Thr
625                 630                 635                 640 
Asp Gly Leu Ser
                


<210> 5393
<211> 427
<212> PRT
<213> Homo sapiens

<400> 5393
Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser
 1               5                  10                  15      
Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp
            20                  25                  30          
Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn
        35                  40                  45              
Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys
    50                  55                  60                  
Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu
65                  70                  75                  80  
Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr
                85                  90                  95      
Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly
            100                 105                 110         
Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile
        115                 120                 125             
Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly
    130                 135                 140                 
Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu
145                 150                 155                 160 
Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu
                165                 170                 175     
Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly
            180                 185                 190         
Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys
        195                 200                 205             
Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly
    210                 215                 220                 
Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg
225                 230                 235                 240 
Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe
                245                 250                 255     
Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro
            260                 265                 270         
Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys
        275                 280                 285             
Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val
    290                 295                 300                 
Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp
305                 310                 315                 320 
Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu
                325                 330                 335     
Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn
            340                 345                 350         
Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val
        355                 360                 365             
Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly
    370                 375                 380                 
Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr
385                 390                 395                 400 
Thr Ser His Leu Arg Ser Cys Glu Tyr Lys Gly Arg Pro Pro Lys Ala
                405                 410                 415     
Gly Ala Glu Pro Ala Ser Glu Arg Glu Val Ser
            420                 425         


<210> 5394
<211> 500
<212> PRT
<213> Homo sapiens

<400> 5394
Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala
 1               5                  10                  15      
Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln
            20                  25                  30          
Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr
        35                  40                  45              
Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser
    50                  55                  60                  
Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala
65                  70                  75                  80  
Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr
                85                  90                  95      
Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp
            100                 105                 110         
Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr
        115                 120                 125             
Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp
    130                 135                 140                 
Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met
145                 150                 155                 160 
Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser
                165                 170                 175     
Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn
            180                 185                 190         
Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln
        195                 200                 205             
Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile
    210                 215                 220                 
Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser
225                 230                 235                 240 
Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp
                245                 250                 255     
Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn
            260                 265                 270         
Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val
        275                 280                 285             
Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp
    290                 295                 300                 
Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile
305                 310                 315                 320 
Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile
                325                 330                 335     
Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn
            340                 345                 350         
Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu
        355                 360                 365             
Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu
    370                 375                 380                 
Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg
385                 390                 395                 400 
Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu
                405                 410                 415     
Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu
            420                 425                 430         
Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu
        435                 440                 445             
Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val
    450                 455                 460                 
Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val
465                 470                 475                 480 
Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr
                485                 490                 495     
Asp Pro Arg Ala
            500 


<210> 5395
<211> 1744
<212> PRT
<213> Homo sapiens

<400> 5395
Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu
 1               5                  10                  15      
Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His
            20                  25                  30          
Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg
        35                  40                  45              
Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn
    50                  55                  60                  
Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg
65                  70                  75                  80  
Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser
                85                  90                  95      
Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala
            100                 105                 110         
His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln
        115                 120                 125             
Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln
    130                 135                 140                 
Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val
145                 150                 155                 160 
Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val
                165                 170                 175     
Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr
            180                 185                 190         
Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser
        195                 200                 205             
Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu
    210                 215                 220                 
Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn
225                 230                 235                 240 
Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro
                245                 250                 255     
Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr
            260                 265                 270         
Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp
        275                 280                 285             
Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys
    290                 295                 300                 
Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln
305                 310                 315                 320 
Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu
                325                 330                 335     
Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met
            340                 345                 350         
Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser
        355                 360                 365             
Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe
    370                 375                 380                 
Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly
385                 390                 395                 400 
Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro
                405                 410                 415     
Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser
            420                 425                 430         
Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val
        435                 440                 445             
Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala
    450                 455                 460                 
Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser
465                 470                 475                 480 
Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val
                485                 490                 495     
Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg
            500                 505                 510         
Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser
        515                 520                 525             
Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val
    530                 535                 540                 
Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val
545                 550                 555                 560 
Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp
                565                 570                 575     
Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu
            580                 585                 590         
Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu
        595                 600                 605             
Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val
    610                 615                 620                 
Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly
625                 630                 635                 640 
Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp
                645                 650                 655     
Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu
            660                 665                 670         
Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn
        675                 680                 685             
Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln
    690                 695                 700                 
Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala
705                 710                 715                 720 
Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys
                725                 730                 735     
Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala
            740                 745                 750         
Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp
        755                 760                 765             
Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp
    770                 775                 780                 
Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro
785                 790                 795                 800 
Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr
                805                 810                 815     
Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu
            820                 825                 830         
Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln
        835                 840                 845             
Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr
    850                 855                 860                 
Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly
865                 870                 875                 880 
Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro
                885                 890                 895     
Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys
            900                 905                 910         
Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser
        915                 920                 925             
Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu
    930                 935                 940                 
Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile
945                 950                 955                 960 
Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser
                965                 970                 975     
Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu
            980                 985                 990         
Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg
        995                 1000                1005            
Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala
    1010                1015                1020                
Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu
1025                1030                1035                1040
Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile
                1045                1050                1055    
Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg
            1060                1065                1070        
Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu
        1075                1080                1085            
Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser
    1090                1095                1100                
Asn Trp Leu Leu Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Pro
1105                1110                1115                1120
Cys Pro Val Leu Asp Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp
                1125                1130                1135    
Glu Thr Val Ala Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly
            1140                1145                1150        
Leu Ala Val Phe Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val
        1155                1160                1165            
Glu Ala Ser Ile Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser
    1170                1175                1180                
Ala Gly Leu Leu Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu
1185                1190                1195                1200
Ser Leu Thr Lys Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn
                1205                1210                1215    
Leu Met Ala Met Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser
            1220                1225                1230        
Val Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg
        1235                1240                1245            
Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr
    1250                1255                1260                
Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu
1265                1270                1275                1280
Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln
                1285                1290                1295    
Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu
            1300                1305                1310        
Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn
        1315                1320                1325            
Val Thr Leu Ser Ser Thr Gly Arg Asn Gly Phe Lys Ser His Ala Leu
    1330                1335                1340                
Gln Leu Asn Asn Arg Gln Ile Arg Gly Leu Glu Glu Glu Leu Gln Phe
1345                1350                1355                1360
Ser Leu Gly Ser Lys Ile Asn Val Lys Val Gly Gly Asn Ser Lys Gly
                1365                1370                1375    
Thr Leu Lys Val Leu Arg Thr Tyr Asn Val Leu Asp Met Lys Asn Thr
            1380                1385                1390        
Thr Cys Gln Asp Leu Gln Ile Glu Val Thr Val Lys Gly His Val Glu
        1395                1400                1405            
Tyr Thr Met Glu Ala Asn Glu Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu
    1410                1415                1420                
Leu Pro Ala Lys Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro
1425                1430                1435                1440
Leu Gln Leu Phe Glu Gly Arg Arg Asn Arg Arg Arg Arg Glu Ala Pro
                1445                1450                1455    
Lys Val Val Glu Glu Gln Glu Ser Arg Val His Tyr Thr Val Cys Ile
            1460                1465                1470        
Trp Arg Asn Gly Lys Val Gly Leu Ser Gly Met Ala Ile Ala Asp Val
        1475                1480                1485            
Thr Leu Leu Ser Gly Phe His Ala Leu Arg Ala Asp Leu Glu Lys Leu
    1490                1495                1500                
Thr Ser Leu Ser Asp Arg Tyr Val Ser His Phe Glu Thr Glu Gly Pro
1505                1510                1515                1520
His Val Leu Leu Tyr Phe Asp Ser Val Pro Thr Ser Arg Glu Cys Val
                1525                1530                1535    
Gly Phe Glu Ala Val Gln Glu Val Pro Val Gly Leu Val Gln Pro Ala
            1540                1545                1550        
Ser Ala Thr Leu Tyr Asp Tyr Tyr Asn Pro Glu Arg Arg Cys Ser Val
        1555                1560                1565            
Phe Tyr Gly Ala Pro Ser Lys Ser Arg Leu Leu Ala Thr Leu Cys Ser
    1570                1575                1580                
Ala Glu Val Cys Gln Cys Ala Glu Gly Lys Cys Pro Arg Gln Arg Arg
1585                1590                1595                1600
Ala Leu Glu Arg Gly Leu Gln Asp Glu Asp Gly Tyr Arg Met Lys Phe
                1605                1610                1615    
Ala Cys Tyr Tyr Pro Arg Val Glu Tyr Gly Phe Gln Val Lys Val Leu
            1620                1625                1630        
Arg Glu Asp Ser Arg Ala Ala Phe Arg Leu Phe Glu Thr Lys Ile Thr
        1635                1640                1645            
Gln Val Leu His Phe Thr Lys Asp Val Lys Ala Ala Ala Asn Gln Met
    1650                1655                1660                
Arg Asn Phe Leu Val Arg Ala Ser Cys Arg Leu Arg Leu Glu Pro Gly
1665                1670                1675                1680
Lys Glu Tyr Leu Ile Met Gly Leu Asp Gly Ala Thr Tyr Asp Leu Glu
                1685                1690                1695    
Gly His Pro Gln Tyr Leu Leu Asp Ser Asn Ser Trp Ile Glu Glu Met
            1700                1705                1710        
Pro Ser Glu Arg Leu Cys Arg Ser Thr Arg Gln Arg Ala Ala Cys Ala
        1715                1720                1725            
Gln Leu Asn Asp Phe Leu Gln Glu Tyr Gly Thr Gln Gly Cys Gln Val
    1730                1735                1740                


<210> 5396
<211> 1741
<212> PRT
<213> Homo sapiens

<400> 5396
Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu
 1               5                  10                  15      
Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His
            20                  25                  30          
Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg
        35                  40                  45              
Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn
    50                  55                  60                  
Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg
65                  70                  75                  80  
Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser
                85                  90                  95      
Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala
            100                 105                 110         
His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln
        115                 120                 125             
Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln
    130                 135                 140                 
Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val
145                 150                 155                 160 
Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val
                165                 170                 175     
Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr
            180                 185                 190         
Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser
        195                 200                 205             
Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu
    210                 215                 220                 
Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn
225                 230                 235                 240 
Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro
                245                 250                 255     
Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr
            260                 265                 270         
Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp
        275                 280                 285             
Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys
    290                 295                 300                 
Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln
305                 310                 315                 320 
Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu
                325                 330                 335     
Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met
            340                 345                 350         
Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser
        355                 360                 365             
Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe
    370                 375                 380                 
Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly
385                 390                 395                 400 
Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro
                405                 410                 415     
Glu Ala Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser
            420                 425                 430         
Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val
        435                 440                 445             
Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala
    450                 455                 460                 
Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser
465                 470                 475                 480 
Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val
                485                 490                 495     
Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg
            500                 505                 510         
Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser
        515                 520                 525             
Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val
    530                 535                 540                 
Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val
545                 550                 555                 560 
Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp
                565                 570                 575     
Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu
            580                 585                 590         
Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu
        595                 600                 605             
Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val
    610                 615                 620                 
Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly
625                 630                 635                 640 
Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp
                645                 650                 655     
Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu
            660                 665                 670         
Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn
        675                 680                 685             
Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln
    690                 695                 700                 
Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala
705                 710                 715                 720 
Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys
                725                 730                 735     
Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala
            740                 745                 750         
Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp
        755                 760                 765             
Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp
    770                 775                 780                 
Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro
785                 790                 795                 800 
Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr
                805                 810                 815     
Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu
            820                 825                 830         
Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln
        835                 840                 845             
Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr
    850                 855                 860                 
Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly
865                 870                 875                 880 
Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro
                885                 890                 895     
Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys
            900                 905                 910         
Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser
        915                 920                 925             
Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu
    930                 935                 940                 
Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile
945                 950                 955                 960 
Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser
                965                 970                 975     
Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu
            980                 985                 990         
Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg
        995                 1000                1005            
Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala
    1010                1015                1020                
Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu
1025                1030                1035                1040
Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile
                1045                1050                1055    
Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg
            1060                1065                1070        
Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu
        1075                1080                1085            
Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser
    1090                1095                1100                
Asn Trp Leu Leu Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Pro
1105                1110                1115                1120
Cys Pro Val Leu Asp Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp
                1125                1130                1135    
Glu Thr Val Ala Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly
            1140                1145                1150        
Leu Ala Val Phe Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val
        1155                1160                1165            
Glu Ala Ser Ile Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser
    1170                1175                1180                
Ala Gly Leu Leu Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu
1185                1190                1195                1200
Ser Leu Thr Lys Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn
                1205                1210                1215    
Leu Met Ala Met Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser
            1220                1225                1230        
Val Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg
        1235                1240                1245            
Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr
    1250                1255                1260                
Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu
1265                1270                1275                1280
Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln
                1285                1290                1295    
Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu
            1300                1305                1310        
Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn
        1315                1320                1325            
Val Thr Leu Ser Ser Thr Gly Arg Asn Gly Phe Lys Ser His Ala Leu
    1330                1335                1340                
Gln Leu Asn Asn Arg Gln Ile Arg Gly Leu Glu Glu Glu Leu Gln Phe
1345                1350                1355                1360
Ser Leu Gly Ser Lys Ile Asn Val Lys Val Gly Gly Asn Ser Lys Gly
                1365                1370                1375    
Thr Leu Lys Val Leu Arg Thr Tyr Asn Val Leu Asp Met Lys Asn Thr
            1380                1385                1390        
Thr Cys Gln Asp Leu Gln Ile Glu Val Thr Val Lys Gly His Val Glu
        1395                1400                1405            
Tyr Thr Met Glu Ala Asn Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala
    1410                1415                1420                
Lys Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu
1425                1430                1435                1440
Phe Glu Gly Arg Arg Asn Arg Arg Arg Arg Glu Ala Pro Lys Val Val
                1445                1450                1455    
Glu Glu Gln Glu Ser Arg Val His Tyr Thr Val Cys Ile Trp Arg Asn
            1460                1465                1470        
Gly Lys Val Gly Leu Ser Gly Met Ala Ile Ala Asp Val Thr Leu Leu
        1475                1480                1485            
Ser Gly Phe His Ala Leu Arg Ala Asp Leu Glu Lys Leu Thr Ser Leu
    1490                1495                1500                
Ser Asp Arg Tyr Val Ser His Phe Glu Thr Glu Gly Pro His Val Leu
1505                1510                1515                1520
Leu Tyr Phe Asp Ser Val Pro Thr Ser Arg Glu Cys Val Gly Phe Glu
                1525                1530                1535    
Ala Val Gln Glu Val Pro Val Gly Leu Val Gln Pro Ala Ser Ala Thr
            1540                1545                1550        
Leu Tyr Asp Tyr Tyr Asn Pro Glu Arg Arg Cys Ser Val Phe Tyr Gly
        1555                1560                1565            
Ala Pro Ser Lys Ser Arg Leu Leu Ala Thr Leu Cys Ser Ala Glu Val
    1570                1575                1580                
Cys Gln Cys Ala Glu Gly Lys Cys Pro Arg Gln Arg Arg Ala Leu Glu
1585                1590                1595                1600
Arg Gly Leu Gln Asp Glu Asp Gly Tyr Arg Met Lys Phe Ala Cys Tyr
                1605                1610                1615    
Tyr Pro Arg Val Glu Tyr Gly Phe Gln Val Lys Val Leu Arg Glu Asp
            1620                1625                1630        
Ser Arg Ala Ala Phe Arg Leu Phe Glu Thr Lys Ile Thr Gln Val Leu
        1635                1640                1645            
His Phe Thr Lys Asp Val Lys Ala Ala Ala Asn Gln Met Arg Asn Phe
    1650                1655                1660                
Leu Val Arg Ala Ser Cys Arg Leu Arg Leu Glu Pro Gly Lys Glu Tyr
1665                1670                1675                1680
Leu Ile Met Gly Leu Asp Gly Ala Thr Tyr Asp Leu Glu Gly His Pro
                1685                1690                1695    
Gln Tyr Leu Leu Asp Ser Asn Ser Trp Ile Glu Glu Met Pro Ser Glu
            1700                1705                1710        
Arg Leu Cys Arg Ser Thr Arg Gln Arg Ala Ala Cys Ala Gln Leu Asn
        1715                1720                1725            
Asp Phe Leu Gln Glu Tyr Gly Thr Gln Gly Cys Gln Val
    1730                1735                1740    


<210> 5397
<211> 464
<212> PRT
<213> Homo sapiens

<400> 5397
Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val
 1               5                  10                  15      
Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys
            20                  25                  30          
His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro
        35                  40                  45              
Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu
    50                  55                  60                  
Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val
65                  70                  75                  80  
Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln
                85                  90                  95      
His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro
            100                 105                 110         
Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn
        115                 120                 125             
Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser
    130                 135                 140                 
Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys
145                 150                 155                 160 
Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn
                165                 170                 175     
Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp
            180                 185                 190         
Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys
        195                 200                 205             
Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn
    210                 215                 220                 
Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn
225                 230                 235                 240 
Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu
                245                 250                 255     
Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr
            260                 265                 270         
Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly
        275                 280                 285             
Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu
    290                 295                 300                 
Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro
305                 310                 315                 320 
Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu
                325                 330                 335     
Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met
            340                 345                 350         
Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln
        355                 360                 365             
Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro
    370                 375                 380                 
Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe
385                 390                 395                 400 
His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala
                405                 410                 415     
Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val
            420                 425                 430         
Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile Arg Glu Val Pro
        435                 440                 445             
Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys
    450                 455                 460                 


<210> 5398
<211> 433
<212> PRT
<213> Homo sapiens

<400> 5398
Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly
 1               5                  10                  15      
Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu
            20                  25                  30          
Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly
        35                  40                  45              
Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu
    50                  55                  60                  
Val Leu Lys Ala Leu Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile
65                  70                  75                  80  
Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu
                85                  90                  95      
Thr Glu Ile Leu Lys Ala Ser Ser Ser Pro His Gly Asp Leu Leu Arg
            100                 105                 110         
Gln Lys Phe Thr Gln Ser Phe Gln His Leu Arg Ala Pro Ser Ile Ser
        115                 120                 125             
Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys
    130                 135                 140                 
Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu
145                 150                 155                 160 
Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala
                165                 170                 175     
Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile
            180                 185                 190         
Thr Asp Leu Ile Lys Asp Pro Asp Ser Gln Thr Met Met Val Leu Val
        195                 200                 205             
Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln
    210                 215                 220                 
Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met
225                 230                 235                 240 
Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp
                245                 250                 255     
Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala
            260                 265                 270         
Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu
        275                 280                 285             
Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu
    290                 295                 300                 
Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg
305                 310                 315                 320 
Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala
                325                 330                 335     
Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu
            340                 345                 350         
Ala Val Ser Gln Val Val His Lys Val Val Ser Asp Val Phe Glu Glu
        355                 360                 365             
Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser
    370                 375                 380                 
Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu
385                 390                 395                 400 
Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys
                405                 410                 415     
Val Thr Asn Pro Ser Lys Pro Arg Ala Cys Ile Lys Gln Trp Gly Ser
            420                 425                 430         
Gln
    


<210> 5399
<211> 679
<212> PRT
<213> Homo sapiens

<400> 5399
Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln
 1               5                  10                  15      
Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val
            20                  25                  30          
Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro
        35                  40                  45              
Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu
    50                  55                  60                  
Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile
65                  70                  75                  80  
Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly
                85                  90                  95      
Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro
            100                 105                 110         
Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile
        115                 120                 125             
Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr
    130                 135                 140                 
Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala
145                 150                 155                 160 
Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile
                165                 170                 175     
Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val
            180                 185                 190         
Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu
        195                 200                 205             
Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile
    210                 215                 220                 
Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg
225                 230                 235                 240 
Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly
                245                 250                 255     
Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr
            260                 265                 270         
Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln
        275                 280                 285             
Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg
    290                 295                 300                 
Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser
305                 310                 315                 320 
Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met
                325                 330                 335     
Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser
            340                 345                 350         
Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala
        355                 360                 365             
Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly
    370                 375                 380                 
Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val
385                 390                 395                 400 
Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr
                405                 410                 415     
Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu
            420                 425                 430         
Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Ser Ala Glu
        435                 440                 445             
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
    450                 455                 460                 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
465                 470                 475                 480 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
                485                 490                 495     
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
            500                 505                 510         
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
        515                 520                 525             
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
    530                 535                 540                 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
545                 550                 555                 560 
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
                565                 570                 575     
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
            580                 585                 590         
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        595                 600                 605             
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    610                 615                 620                 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
625                 630                 635                 640 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
                645                 650                 655     
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            660                 665                 670         
Leu Ser Leu Ser Pro Gly Lys
        675                 


<210> 5400
<211> 330
<212> PRT
<213> Homo sapiens

<400> 5400
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 5401
<211> 470
<212> PRT
<213> Homo sapiens

<400> 5401
Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Val Ile Leu Glu Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Leu
        35                  40                  45              
Asn Asn Tyr Asp Met His Trp Val Arg Gln Gly Ile Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Lys Ile Gly Thr Ala Gly Asp Arg Tyr Tyr Ala Gly
65                  70                  75                  80  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asp Ser
                85                  90                  95      
Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Gly Asp Ala Ala Val Tyr
            100                 105                 110         
Tyr Cys Ala Arg Gly Ala Gly Arg Trp Ala Pro Leu Gly Ala Phe Asp
        115                 120                 125             
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
                165                 170                 175     
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
        195                 200                 205             
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
    210                 215                 220                 
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
225                 230                 235                 240 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
                245                 250                 255     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
            260                 265                 270         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
        275                 280                 285             
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
    290                 295                 300                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
305                 310                 315                 320 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
                325                 330                 335     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
            340                 345                 350         
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
        355                 360                 365             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
    370                 375                 380                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
385                 390                 395                 400 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
                405                 410                 415     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
            420                 425                 430         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
    450                 455                 460                 
Ser Leu Ser Pro Gly Lys
465                 470 


<210> 5402
<211> 482
<212> PRT
<213> Homo sapiens

<400> 5402
Met Glu Phe Gly Leu Thr Trp Val Phe Val Val Ala Leu Leu Arg Gly
 1               5                  10                  15      
Val Gln Cys Gln Ala Gln Val Val Glu Ser Gly Gly Ser Val Val Gln
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Phe Ser Phe
        35                  40                  45              
Ser Gly Ser Ala Met His Trp Leu Arg Gln Ile Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Asn His Lys Leu Tyr Ser
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser
                85                  90                  95      
Leu Leu Phe Leu His Val Asn Ser Leu Thr Ser Ala Asp Thr Ala Ile
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Phe His Ser Lys Thr Thr Ser Ile Phe Gly
        115                 120                 125             
Leu Ile Pro Leu Tyr Phe Tyr Tyr Ser Ala Met Asp Thr Trp Gly Arg
    130                 135                 140                 
Gly Thr Thr Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
145                 150                 155                 160 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
                165                 170                 175     
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
            180                 185                 190         
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
        195                 200                 205             
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
    210                 215                 220                 
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
225                 230                 235                 240 
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
                245                 250                 255     
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
            260                 265                 270         
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
        275                 280                 285             
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
    290                 295                 300                 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
305                 310                 315                 320 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
                325                 330                 335     
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
            340                 345                 350         
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
        355                 360                 365             
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
    370                 375                 380                 
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
385                 390                 395                 400 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
                405                 410                 415     
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
            420                 425                 430         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
        435                 440                 445             
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
    450                 455                 460                 
Glu Gly Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
465                 470                 475                 480 
Gly Lys
        


<210> 5403
<211> 189
<212> PRT
<213> Homo sapiens

<400> 5403
Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly
 1               5                  10                  15      
Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro
            20                  25                  30          
Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu
        35                  40                  45              
Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala
    50                  55                  60                  
Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu
65                  70                  75                  80  
Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro
                85                  90                  95      
Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe
            100                 105                 110         
Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr
        115                 120                 125             
Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp
    130                 135                 140                 
Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val
145                 150                 155                 160 
Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys
                165                 170                 175     
Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser
            180                 185                 


<210> 5404
<211> 462
<212> PRT
<213> Homo sapiens

<400> 5404
Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu
 1               5                  10                  15      
Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His
            20                  25                  30          
Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu
        35                  40                  45              
Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn
    50                  55                  60                  
Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys
65                  70                  75                  80  
Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro
                85                  90                  95      
Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys
            100                 105                 110         
Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr
        115                 120                 125             
Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp
    130                 135                 140                 
Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu
145                 150                 155                 160 
Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr
                165                 170                 175     
Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu
            180                 185                 190         
Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg
        195                 200                 205             
Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val
    210                 215                 220                 
Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn
225                 230                 235                 240 
Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg
                245                 250                 255     
Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly
            260                 265                 270         
Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser
        275                 280                 285             
Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly
    290                 295                 300                 
Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu
305                 310                 315                 320 
Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr
                325                 330                 335     
Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro
            340                 345                 350         
His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly
        355                 360                 365             
Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp
    370                 375                 380                 
Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His
385                 390                 395                 400 
Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn
                405                 410                 415     
Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn
            420                 425                 430         
Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu
        435                 440                 445             
Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His
    450                 455                 460         


<210> 5405
<211> 930
<212> PRT
<213> Homo sapiens

<400> 5405
Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu
 1               5                  10                  15      
Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly
            20                  25                  30          
Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe
        35                  40                  45              
Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val
    50                  55                  60                  
Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr
65                  70                  75                  80  
Asn Phe Ser Met Asn Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys
                85                  90                  95      
Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly
            100                 105                 110         
Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe
        115                 120                 125             
Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu
    130                 135                 140                 
Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu
145                 150                 155                 160 
Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile
                165                 170                 175     
His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr
            180                 185                 190         
Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys
        195                 200                 205             
Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys
    210                 215                 220                 
Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg
225                 230                 235                 240 
Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn
                245                 250                 255     
Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro
            260                 265                 270         
Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg
        275                 280                 285             
Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu
    290                 295                 300                 
Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr
305                 310                 315                 320 
Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys
                325                 330                 335     
Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile
            340                 345                 350         
Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln
        355                 360                 365             
Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr
    370                 375                 380                 
Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn
385                 390                 395                 400 
Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly
                405                 410                 415     
Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp
            420                 425                 430         
Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu
        435                 440                 445             
Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala
    450                 455                 460                 
Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn
465                 470                 475                 480 
Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys
                485                 490                 495     
Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys
            500                 505                 510         
Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu
        515                 520                 525             
Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met
    530                 535                 540                 
Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr
545                 550                 555                 560 
Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu
                565                 570                 575     
Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val
            580                 585                 590         
Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro
        595                 600                 605             
Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Gly Ser Thr Phe
    610                 615                 620                 
Phe Lys Tyr Tyr Leu Gln Gly Ala Lys Ile Pro Lys Pro Glu Ala Ser
625                 630                 635                 640 
Phe Ser Pro Arg Arg Gly Trp Asn Arg Gln Ala Gly Ala Ala Gly Ser
                645                 650                 655     
Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu Gly Leu
            660                 665                 670         
Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg
        675                 680                 685             
Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser Asn Pro
    690                 695                 700                 
Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu Thr Thr
705                 710                 715                 720 
Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala Ile Leu
                725                 730                 735     
Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro Arg His
            740                 745                 750         
Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val Glu
        755                 760                 765             
Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu
    770                 775                 780                 
Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His
785                 790                 795                 800 
Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu
                805                 810                 815     
Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr
            820                 825                 830         
Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu
        835                 840                 845             
Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr
    850                 855                 860                 
Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln
865                 870                 875                 880 
Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr
                885                 890                 895     
Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu
            900                 905                 910         
Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val
        915                 920                 925             
Glu Leu
    930 


<210> 5406
<211> 914
<212> PRT
<213> Homo sapiens

<400> 5406
Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu
 1               5                  10                  15      
Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly
            20                  25                  30          
Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe
        35                  40                  45              
Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val
    50                  55                  60                  
Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr
65                  70                  75                  80  
Asn Phe Ser Met Asn Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys
                85                  90                  95      
Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly
            100                 105                 110         
Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe
        115                 120                 125             
Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu
    130                 135                 140                 
Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu
145                 150                 155                 160 
Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile
                165                 170                 175     
His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr
            180                 185                 190         
Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys
        195                 200                 205             
Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys
    210                 215                 220                 
Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg
225                 230                 235                 240 
Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn
                245                 250                 255     
Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro
            260                 265                 270         
Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg
        275                 280                 285             
Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu
    290                 295                 300                 
Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr
305                 310                 315                 320 
Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys
                325                 330                 335     
Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile
            340                 345                 350         
Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln
        355                 360                 365             
Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr
    370                 375                 380                 
Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn
385                 390                 395                 400 
Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly
                405                 410                 415     
Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp
            420                 425                 430         
Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu
        435                 440                 445             
Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala
    450                 455                 460                 
Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn
465                 470                 475                 480 
Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys
                485                 490                 495     
Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys
            500                 505                 510         
Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu
        515                 520                 525             
Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met
    530                 535                 540                 
Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr
545                 550                 555                 560 
Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu
                565                 570                 575     
Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val
            580                 585                 590         
Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro
        595                 600                 605             
Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Ala Gly Ala Ala
    610                 615                 620                 
Gly Ser Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu
625                 630                 635                 640 
Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro
                645                 650                 655     
Phe Arg Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser
            660                 665                 670         
Asn Pro Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu
        675                 680                 685             
Thr Thr Met Thr Thr Gln Thr Pro Ala Cys Pro Ser Cys Ser Arg Ser
    690                 695                 700                 
Arg Ala Pro Ala Val Pro Ala Pro Ile Gln Ala Pro Ser Ala Ile Leu
705                 710                 715                 720 
Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro Arg His
                725                 730                 735     
Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val Glu
            740                 745                 750         
Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu
        755                 760                 765             
Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His
    770                 775                 780                 
Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu
785                 790                 795                 800 
Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr
                805                 810                 815     
Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu
            820                 825                 830         
Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr
        835                 840                 845             
Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln
    850                 855                 860                 
Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr
865                 870                 875                 880 
Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu
                885                 890                 895     
Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val
            900                 905                 910         
Glu Leu
        


<210> 5407
<211> 1231
<212> PRT
<213> Homo sapiens

<400> 5407
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys
 1               5                  10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys
        435                 440                 445             
Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln
    450                 455                 460                 
Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly
465                 470                 475                 480 
Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Arg Cys Gly Lys
                485                 490                 495     
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro
            500                 505                 510         
Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu
        515                 520                 525             
Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr
    530                 535                 540                 
Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp
545                 550                 555                 560 
Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val
                565                 570                 575     
His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val
            580                 585                 590         
Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser
        595                 600                 605             
Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys
    610                 615                 620                 
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn
625                 630                 635                 640 
Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu
                645                 650                 655     
Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln
            660                 665                 670         
Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu
        675                 680                 685             
Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu
    690                 695                 700                 
Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser
705                 710                 715                 720 
Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly
                725                 730                 735     
Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys
            740                 745                 750         
Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys
        755                 760                 765             
Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys
    770                 775                 780                 
Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu
785                 790                 795                 800 
Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln
                805                 810                 815     
Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly
            820                 825                 830         
Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly
        835                 840                 845             
Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys
    850                 855                 860                 
Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr
865                 870                 875                 880 
Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys
                885                 890                 895     
Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu
            900                 905                 910         
Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly
        915                 920                 925             
Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His
    930                 935                 940                 
Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe
945                 950                 955                 960 
Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu
                965                 970                 975     
Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu
            980                 985                 990         
Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr
        995                 1000                1005            
Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met
    1010                1015                1020                
Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg
1025                1030                1035                1040
Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn
                1045                1050                1055    
Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg
            1060                1065                1070        
Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu
        1075                1080                1085            
Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp
    1090                1095                1100                
Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile
1105                1110                1115                1120
Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr
                1125                1130                1135    
Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys
            1140                1145                1150        
Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val
        1155                1160                1165            
Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr
    1170                1175                1180                
Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val
1185                1190                1195                1200
Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr
                1205                1210                1215    
Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg
            1220                1225                1230    


<210> 5408
<211> 947
<212> PRT
<213> Homo sapiens

<400> 5408
Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val
 1               5                  10                  15      
Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr
            20                  25                  30          
Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu
        35                  40                  45              
Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met
    50                  55                  60                  
Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr
65                  70                  75                  80  
Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn
                85                  90                  95      
Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys
            100                 105                 110         
Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe
        115                 120                 125             
Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln
    130                 135                 140                 
Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu
145                 150                 155                 160 
Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys
                165                 170                 175     
Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly
            180                 185                 190         
Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His
        195                 200                 205             
Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu
    210                 215                 220                 
His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile
225                 230                 235                 240 
Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala
                245                 250                 255     
Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr Ala Val Asp Gly Glu
            260                 265                 270         
Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu
        275                 280                 285             
Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu
    290                 295                 300                 
Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser
305                 310                 315                 320 
Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile
                325                 330                 335     
Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn
            340                 345                 350         
Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr
        355                 360                 365             
Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly
    370                 375                 380                 
Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn
385                 390                 395                 400 
Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile
                405                 410                 415     
Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Lys Cys Glu Leu Lys
            420                 425                 430         
Leu Ser Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile
        435                 440                 445             
Ser Leu Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu
    450                 455                 460                 
Lys Arg Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly
465                 470                 475                 480 
Asn Gln Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser
                485                 490                 495     
Thr Pro Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val
            500                 505                 510         
Thr Asp Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu
        515                 520                 525             
Ile Val Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu
    530                 535                 540                 
Ser Val Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr
545                 550                 555                 560 
Leu Ala Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His
                565                 570                 575     
Ala Asp Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn
            580                 585                 590         
Gln Leu Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg
        595                 600                 605             
Arg Ile Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val
    610                 615                 620                 
Thr Pro Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg
625                 630                 635                 640 
Met Leu Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala
                645                 650                 655     
Leu Tyr Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala
            660                 665                 670         
Asn Pro Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln
        675                 680                 685             
Val Leu Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp
    690                 695                 700                 
Pro His Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe
705                 710                 715                 720 
Asn Ile Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro
                725                 730                 735     
Glu Ser Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro
            740                 745                 750         
Asn Asn Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe
        755                 760                 765             
Gln Ser Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu
    770                 775                 780                 
Ser His Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln
785                 790                 795                 800 
Val Thr Asn Gln Arg Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr
                805                 810                 815     
Ile Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val
            820                 825                 830         
Trp Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro
        835                 840                 845             
Pro Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe
    850                 855                 860                 
Met Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp
865                 870                 875                 880 
Pro Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile
                885                 890                 895     
Ile Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly
            900                 905                 910         
Thr Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile
        915                 920                 925             
Asp Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu
    930                 935                 940                 
Lys Arg Pro
945         


<210> 5409
<211> 495
<212> PRT
<213> Homo sapiens

<400> 5409
Met Ser Met Leu Val Val Phe Leu Leu Leu Trp Gly Val Thr Trp Gly
 1               5                  10                  15      
Pro Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln Pro Ser Leu Trp
            20                  25                  30          
Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Asn Val Thr Leu Thr
        35                  40                  45              
Cys Gln Ala Arg Leu Glu Thr Pro Asp Phe Gln Leu Phe Lys Asn Gly
    50                  55                  60                  
Val Ala Gln Glu Pro Val His Leu Asp Ser Pro Ala Ile Lys His Gln
65                  70                  75                  80  
Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg Tyr Arg Cys Arg Ser Gly
                85                  90                  95      
Leu Ser Thr Gly Trp Thr Gln Leu Gly Lys Leu Leu Glu Leu Thr Gly
            100                 105                 110         
Pro Lys Ser Leu Pro Ala Pro Trp Leu Ser Met Ala Pro Val Pro Trp
        115                 120                 125             
Ile Thr Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val Leu Arg
    130                 135                 140                 
Gly Glu Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe Leu Glu
145                 150                 155                 160 
Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val His Gln
                165                 170                 175     
Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly Glu Gly Ala Leu
            180                 185                 190         
Ser Glu Pro Ser Ala Thr Val Thr Ile Glu Glu Leu Ala Ala Pro Pro
        195                 200                 205             
Pro Pro Val Leu Met His His Gly Glu Ser Ser Gln Val Leu His Pro
    210                 215                 220                 
Gly Asn Lys Val Thr Leu Thr Cys Val Ala Pro Leu Ser Gly Val Asp
225                 230                 235                 240 
Phe Gln Leu Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser
                245                 250                 255     
Thr Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly
            260                 265                 270         
Asp Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn
        275                 280                 285             
Gly Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser Asp Glu
    290                 295                 300                 
Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu Ser Gly Arg Ala
305                 310                 315                 320 
Leu Arg Leu Arg Cys Leu Ala Pro Leu Glu Gly Ala Arg Phe Ala Leu
                325                 330                 335     
Val Arg Glu Asp Arg Gly Gly Arg Arg Val His Arg Phe Gln Ser Pro
            340                 345                 350         
Ala Gly Thr Glu Ala Leu Phe Glu Leu His Asn Ile Ser Val Ala Asp
        355                 360                 365             
Ser Ala Asn Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe Gly
    370                 375                 380                 
Gly Ser Ala Pro Ser Glu Arg Leu Glu Leu His Val Asp Gly Pro Pro
385                 390                 395                 400 
Pro Arg Pro Gln Leu Arg Ala Thr Trp Ser Gly Ala Ala Leu Ala Gly
                405                 410                 415     
Arg Asp Ala Val Leu Arg Cys Glu Gly Pro Ile Pro Asp Val Thr Phe
            420                 425                 430         
Glu Leu Leu Arg Glu Gly Glu Thr Lys Ala Val Lys Thr Ile Pro Thr
        435                 440                 445             
Pro Gly Ala Ala Ala Asn Leu Glu Leu Ile Phe Val Gly Pro Gln His
    450                 455                 460                 
Ala Gly Asn Tyr Arg Cys Arg Tyr Arg Ser Trp Val Pro His Thr Phe
465                 470                 475                 480 
Glu Ser Glu Leu Ser Asp Pro Val Glu Leu Leu Val Ala Glu Ser
                485                 490                 495 


<210> 5410
<211> 495
<212> PRT
<213> Homo sapiens

<400> 5410
Met Ser Met Leu Val Val Phe Leu Leu Leu Trp Gly Val Thr Trp Gly
 1               5                  10                  15      
Pro Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln Pro Ser Leu Trp
            20                  25                  30          
Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Asn Val Thr Leu Thr
        35                  40                  45              
Cys Gln Ala His Leu Glu Thr Pro Asp Phe Gln Leu Phe Lys Asn Gly
    50                  55                  60                  
Val Ala Gln Glu Pro Val His Leu Asp Ser Pro Ala Ile Lys His Gln
65                  70                  75                  80  
Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg Tyr Arg Cys Arg Ser Gly
                85                  90                  95      
Leu Ser Thr Gly Trp Thr Gln Leu Ser Lys Leu Leu Glu Leu Thr Gly
            100                 105                 110         
Pro Lys Ser Leu Pro Ala Pro Trp Leu Ser Met Ala Pro Val Ser Trp
        115                 120                 125             
Ile Thr Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val Leu Arg
    130                 135                 140                 
Gly Val Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe Leu Glu
145                 150                 155                 160 
Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val His Gln
                165                 170                 175     
Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly Glu Gly Ala Leu
            180                 185                 190         
Ser Glu Pro Ser Ala Thr Val Thr Ile Glu Glu Leu Ala Ala Pro Pro
        195                 200                 205             
Pro Pro Val Leu Met His His Gly Glu Ser Ser Gln Val Leu His Pro
    210                 215                 220                 
Gly Asn Lys Val Thr Leu Thr Cys Val Ala Pro Leu Ser Gly Val Asp
225                 230                 235                 240 
Phe Gln Leu Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser
                245                 250                 255     
Thr Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly
            260                 265                 270         
Asp Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn
        275                 280                 285             
Gly Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser Asp Glu
    290                 295                 300                 
Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu Ser Gly Arg Ala
305                 310                 315                 320 
Leu Arg Leu Arg Cys Leu Ala Pro Leu Glu Gly Ala Arg Phe Ala Leu
                325                 330                 335     
Val Arg Glu Asp Arg Gly Gly Arg Arg Val His Arg Phe Gln Ser Pro
            340                 345                 350         
Ala Gly Thr Glu Ala Leu Phe Glu Leu His Asn Ile Ser Val Ala Asp
        355                 360                 365             
Ser Ala Asn Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe Gly
    370                 375                 380                 
Gly Ser Ala Pro Ser Glu Arg Leu Glu Leu His Val Asp Gly Pro Pro
385                 390                 395                 400 
Pro Arg Pro Gln Leu Arg Ala Thr Trp Ser Gly Ala Val Leu Ala Gly
                405                 410                 415     
Arg Asp Ala Val Leu Arg Cys Glu Gly Pro Ile Pro Asp Val Thr Phe
            420                 425                 430         
Glu Leu Leu Arg Glu Gly Glu Thr Lys Ala Val Lys Thr Val Arg Thr
        435                 440                 445             
Pro Gly Ala Ala Ala Asn Leu Glu Leu Ile Phe Val Gly Pro Gln His
    450                 455                 460                 
Ala Gly Asn Tyr Arg Cys Arg Tyr Arg Ser Trp Val Pro His Thr Phe
465                 470                 475                 480 
Glu Ser Glu Leu Ser Asp Pro Val Glu Leu Leu Val Ala Glu Ser
                485                 490                 495 


<210> 5411
<211> 260
<212> PRT
<213> Homo sapiens

<400> 5411
Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val
 1               5                  10                  15      
Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys
            20                  25                  30          
His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro
        35                  40                  45              
Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu
    50                  55                  60                  
Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val
65                  70                  75                  80  
Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln
                85                  90                  95      
His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro
            100                 105                 110         
Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn
        115                 120                 125             
Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser
    130                 135                 140                 
Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys
145                 150                 155                 160 
Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn
                165                 170                 175     
Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp
            180                 185                 190         
Ile Asn Ala Phe His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser
        195                 200                 205             
Glu Ala Ala Ala Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn
    210                 215                 220                 
Pro Asn Arg Val Thr Phe Lys Ala Asn Arg Pro Phe Leu Val Phe Ile
225                 230                 235                 240 
Arg Glu Val Pro Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn
                245                 250                 255     
Pro Cys Val Lys
            260 


<210> 5412
<211> 298
<212> PRT
<213> Homo sapiens

<400> 5412
Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly
 1               5                  10                  15      
Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr
            20                  25                  30          
Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln
        35                  40                  45              
Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys
    50                  55                  60                  
Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met
65                  70                  75                  80  
Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile
                85                  90                  95      
Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn
            100                 105                 110         
Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn
        115                 120                 125             
Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr
    130                 135                 140                 
Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala
145                 150                 155                 160 
Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln
                165                 170                 175     
Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys
            180                 185                 190         
Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser
        195                 200                 205             
Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys
    210                 215                 220                 
Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr
225                 230                 235                 240 
Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His
                245                 250                 255     
Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro
            260                 265                 270         
Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala
        275                 280                 285             
Gln Pro Leu Val Val Pro Trp Glu Ala Ser
    290                 295             


<210> 5413
<211> 345
<212> PRT
<213> Homo sapiens

<400> 5413
Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val
 1               5                  10                  15      
Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser
            20                  25                  30          
Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr
        35                  40                  45              
Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe
    50                  55                  60                  
Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr
65                  70                  75                  80  
Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg
                85                  90                  95      
Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr
            100                 105                 110         
Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly
        115                 120                 125             
Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro
    130                 135                 140                 
Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala
145                 150                 155                 160 
Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro
                165                 170                 175     
Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly
            180                 185                 190         
Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro
        195                 200                 205             
Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu
    210                 215                 220                 
Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu
225                 230                 235                 240 
Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala
                245                 250                 255     
Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr
            260                 265                 270         
Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn
        275                 280                 285             
Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu
    290                 295                 300                 
Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile
305                 310                 315                 320 
Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys
                325                 330                 335     
Thr Asp Ala Ser Asp Val Lys Pro Cys
            340                 345 


<210> 5414
<211> 476
<212> PRT
<213> Homo sapiens

<400> 5414
His Asn Ala Ala Ser Pro Gly Gly Ala Arg Gly His Arg Val Pro Leu
 1               5                  10                  15      
Thr Glu Ala Cys Lys Asp Ser Arg Ile Gly Gly Met Met Lys Thr Leu
            20                  25                  30          
Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu Ser Gly Gln Val Leu
        35                  40                  45              
Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn Gln
    50                  55                  60                  
Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly Val
65                  70                  75                  80  
Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys Thr
                85                  90                  95      
Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala Leu
            100                 105                 110         
Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val
        115                 120                 125             
Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu
    130                 135                 140                 
Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser
145                 150                 155                 160 
Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro
                165                 170                 175     
Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn
            180                 185                 190         
Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe Ser
        195                 200                 205             
Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr
    210                 215                 220                 
Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His
225                 230                 235                 240 
Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu
                245                 250                 255     
Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln
            260                 265                 270         
Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His
        275                 280                 285             
Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu
    290                 295                 300                 
Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr
305                 310                 315                 320 
Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu
                325                 330                 335     
Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg
            340                 345                 350         
Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr
        355                 360                 365             
Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser
    370                 375                 380                 
Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala
385                 390                 395                 400 
Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val
                405                 410                 415     
Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val
            420                 425                 430         
Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val
        435                 440                 445             
Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys
    450                 455                 460                 
Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu
465                 470                 475     


<210> 5415
<211> 159
<212> PRT
<213> Homo sapiens

<400> 5415
Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys
 1               5                  10                  15      
Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp
            20                  25                  30          
Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser
        35                  40                  45              
Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val
    50                  55                  60                  
Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg
65                  70                  75                  80  
Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro
                85                  90                  95      
Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn
            100                 105                 110         
Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg
        115                 120                 125             
Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr
    130                 135                 140                 
Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp
145                 150                 155                 


<210> 5416
<211> 478
<212> PRT
<213> Homo sapiens

<400> 5416
Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val
 1               5                  10                  15      
Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe
            20                  25                  30          
Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln
        35                  40                  45              
Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg
    50                  55                  60                  
Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp
65                  70                  75                  80  
Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro
                85                  90                  95      
Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln
            100                 105                 110         
Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly
        115                 120                 125             
Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro
    130                 135                 140                 
Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro
145                 150                 155                 160 
Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg
                165                 170                 175     
Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr
            180                 185                 190         
Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala
        195                 200                 205             
Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly
    210                 215                 220                 
Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro
225                 230                 235                 240 
Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala
                245                 250                 255     
Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr
            260                 265                 270         
Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro
        275                 280                 285             
Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His
    290                 295                 300                 
Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu
305                 310                 315                 320 
Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser
                325                 330                 335     
Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly
            340                 345                 350         
Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys
        355                 360                 365             
Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly
    370                 375                 380                 
His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr
385                 390                 395                 400 
Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn
                405                 410                 415     
Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro
            420                 425                 430         
Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn
        435                 440                 445             
Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser
    450                 455                 460                 
Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu
465                 470                 475             


<210> 5417
<211> 245
<212> PRT
<213> Homo sapiens

<400> 5417
Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser
 1               5                  10                  15      
Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys
            20                  25                  30          
Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys
        35                  40                  45              
Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln
    50                  55                  60                  
Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly
65                  70                  75                  80  
Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile
                85                  90                  95      
Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln
            100                 105                 110         
Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly
        115                 120                 125             
Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr
    130                 135                 140                 
Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr
145                 150                 155                 160 
Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val
                165                 170                 175     
Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr
            180                 185                 190         
Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln
        195                 200                 205             
Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly
    210                 215                 220                 
His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu
225                 230                 235                 240 
Ile Phe Pro Ser Ala
                245 


<210> 5418
<211> 347
<212> PRT
<213> Homo sapiens

<400> 5418
Met Ser Ser Trp Ser Arg Gln Arg Pro Lys Ser Pro Gly Gly Ile Gln
 1               5                  10                  15      
Pro His Val Ser Arg Thr Leu Phe Leu Leu Leu Leu Leu Ala Ala Ser
            20                  25                  30          
Ala Trp Gly Val Thr Leu Ser Pro Lys Asp Cys Gln Val Phe Arg Ser
        35                  40                  45              
Asp His Gly Ser Ser Ile Ser Cys Gln Pro Pro Ala Glu Ile Pro Gly
    50                  55                  60                  
Tyr Leu Pro Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu
65                  70                  75                  80  
Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys Leu Gln Glu
                85                  90                  95      
Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu
            100                 105                 110         
Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu
        115                 120                 125             
Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr Leu Asp Thr
    130                 135                 140                 
Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val Ser Trp Leu
145                 150                 155                 160 
His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu
                165                 170                 175     
Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr
            180                 185                 190         
Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro Asp Leu Leu
        195                 200                 205             
Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu
    210                 215                 220                 
Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg Tyr
225                 230                 235                 240 
Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe
                245                 250                 255     
Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu
            260                 265                 270         
Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp
        275                 280                 285             
Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp
    290                 295                 300                 
Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln Lys Asp Lys
305                 310                 315                 320 
Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys
                325                 330                 335     
Gly Gln Thr Leu Leu Ala Val Ala Lys Ser Gln
            340                 345         


<210> 5419
<211> 338
<212> PRT
<213> Homo sapiens

<400> 5419
Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr
 1               5                  10                  15      
Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln
            20                  25                  30          
Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro
        35                  40                  45              
Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val
    50                  55                  60                  
Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His
65                  70                  75                  80  
Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile
                85                  90                  95      
Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe
            100                 105                 110         
Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu
        115                 120                 125             
Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu
    130                 135                 140                 
Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn
145                 150                 155                 160 
Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val
                165                 170                 175     
Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser
            180                 185                 190         
Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu
        195                 200                 205             
Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr
    210                 215                 220                 
Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu
225                 230                 235                 240 
Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu
                245                 250                 255     
Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val
            260                 265                 270         
Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys
        275                 280                 285             
Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser
    290                 295                 300                 
Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser
305                 310                 315                 320 
Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr
                325                 330                 335     
Leu Asn
        


<210> 5420
<211> 111
<212> PRT
<213> Homo sapiens

<400> 5420
Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln Asp
 1               5                  10                  15      
Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr Val
            20                  25                  30          
Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser Leu
        35                  40                  45              
Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala Asn
    50                  55                  60                  
Thr Thr Glu Ala Val Leu Gly Asp Ala Leu Val Asp Phe Ser Leu Lys
65                  70                  75                  80  
Leu Tyr His Ala Phe Ser Ala Met Lys Lys Val Glu Thr Asn Met Ala
                85                  90                  95      
Phe Ser Pro Phe Ser Ile Ala Ser Leu Leu Thr Gln Val Leu Leu
            100                 105                 110     


<210> 5421
<211> 616
<212> PRT
<213> Homo sapiens

<400> 5421
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp
 1               5                  10                  15      
Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile
        35                  40                  45              
Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro
65                  70                  75                  80  
Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln
                85                  90                  95      
Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
            100                 105                 110         
Tyr Cys Ala Arg Asp Thr Val Arg Gly Gly Thr Val Ser Leu Cys Asp
        115                 120                 125             
Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
    130                 135                 140                 
Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn Ser
145                 150                 155                 160 
Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp Phe
                165                 170                 175     
Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser Asp
            180                 185                 190         
Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys Tyr
        195                 200                 205             
Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln Gly
    210                 215                 220                 
Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn Lys
225                 230                 235                 240 
Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys Val
                245                 250                 255     
Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys
            260                 265                 270         
Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln
        275                 280                 285             
Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr
    290                 295                 300                 
Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys
305                 310                 315                 320 
Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln Ser
                325                 330                 335     
Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn
            340                 345                 350         
Ala Ser Ser Met Cys Gly Pro Asp Gln Asp Thr Ala Ile Arg Val Phe
        355                 360                 365             
Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys
    370                 375                 380                 
Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr Ile
385                 390                 395                 400 
Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn Ile
                405                 410                 415     
Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser
            420                 425                 430         
Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr Val
        435                 440                 445             
Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro
    450                 455                 460                 
Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala
465                 470                 475                 480 
Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val
                485                 490                 495     
Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly
            500                 505                 510         
Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu
        515                 520                 525             
Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser
    530                 535                 540                 
Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His
545                 550                 555                 560 
Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr
                565                 570                 575     
Glu Gly Glu Val Ser Ala Asp Glu Glu Gly Phe Glu Asn Leu Trp Ala
            580                 585                 590         
Thr Ala Ser Thr Phe Ile Val Leu Phe Leu Leu Ser Leu Phe Tyr Ser
        595                 600                 605             
Thr Thr Val Thr Leu Phe Lys Val
    610                 615     


<210> 5422
<211> 597
<212> PRT
<213> Homo sapiens

<400> 5422
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe
        35                  40                  45              
Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asp
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Lys Asp Pro Arg Gly Tyr Ser Ala Ser Gly Asn Tyr
        115                 120                 125             
Thr Arg Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140                 
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn
145                 150                 155                 160 
Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp
                165                 170                 175     
Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser
            180                 185                 190         
Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys
        195                 200                 205             
Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln
    210                 215                 220                 
Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn
225                 230                 235                 240 
Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys
                245                 250                 255     
Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg
            260                 265                 270         
Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile
        275                 280                 285             
Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr
    290                 295                 300                 
Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr
305                 310                 315                 320 
Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln
                325                 330                 335     
Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln
            340                 345                 350         
Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val
        355                 360                 365             
Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr
    370                 375                 380                 
Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr
385                 390                 395                 400 
Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn
                405                 410                 415     
Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala
            420                 425                 430         
Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr
        435                 440                 445             
Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg
    450                 455                 460                 
Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro
465                 470                 475                 480 
Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu
                485                 490                 495     
Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg
            500                 505                 510         
Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro
        515                 520                 525             
Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val
    530                 535                 540                 
Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala
545                 550                 555                 560 
His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser
                565                 570                 575     
Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr
            580                 585                 590         
Ala Gly Thr Cys Tyr
        595         


<210> 5423
<211> 614
<212> PRT
<213> Homo sapiens

<400> 5423
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Asp
 1               5                  10                  15      
Ala Tyr Ser Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Thr Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Tyr Arg Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile Thr Pro Phe Asn Gly Asn Thr Asn Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Asn
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Tyr Ser Ser Ser Trp Asp Asp Ala Phe Asp
        115                 120                 125             
Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Ala Ser
    130                 135                 140                 
Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn Ser Pro Ser Asp
145                 150                 155                 160 
Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp Phe Leu Pro Asp
                165                 170                 175     
Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser Asp Ile Ser Ser
            180                 185                 190         
Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys Tyr Ala Ala Thr
        195                 200                 205             
Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln Gly Thr Asp Glu
    210                 215                 220                 
His Val Val Cys Lys Val Gln His Pro Asn Gly Asn Lys Glu Lys Asn
225                 230                 235                 240 
Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe
                245                 250                 255     
Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu
            260                 265                 270         
Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp
        275                 280                 285             
Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val
    290                 295                 300                 
Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser
305                 310                 315                 320 
Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln Ser Met Phe Thr
                325                 330                 335     
Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser
            340                 345                 350         
Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro
        355                 360                 365             
Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys
    370                 375                 380                 
Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr
385                 390                 395                 400 
Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser
                405                 410                 415     
His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu
            420                 425                 430         
Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr
        435                 440                 445             
Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly Val
    450                 455                 460                 
Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln
465                 470                 475                 480 
Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly Phe
                485                 490                 495     
Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro Leu
            500                 505                 510         
Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln Ala
        515                 520                 525             
Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu Glu
    530                 535                 540                 
Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu Ala Leu
545                 550                 555                 560 
Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Glu Gly Glu
                565                 570                 575     
Val Ser Ala Asp Glu Glu Gly Phe Glu Asn Leu Trp Ala Thr Ala Ser
            580                 585                 590         
Thr Phe Ile Val Leu Phe Leu Leu Ser Leu Phe Tyr Ser Thr Thr Val
        595                 600                 605             
Thr Leu Phe Lys Val Lys
    610                 


<210> 5424
<211> 618
<212> PRT
<213> Homo sapiens

<400> 5424
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp
 1               5                  10                  15      
Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys
            20                  25                  30          
Pro Ser Glu Thr Leu Ser Leu Thr Cys Gly Val Tyr Gly Gly Ser Phe
        35                  40                  45              
Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro
65                  70                  75                  80  
Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln
                85                  90                  95      
Leu Ser Leu Lys Leu Ser Ser Val Asn Ala Ala Asp Thr Ala Val Tyr
            100                 105                 110         
Tyr Cys Ala Arg Val Ile Thr Arg Ala Ser Pro Gly Thr Asp Gly Arg
        115                 120                 125             
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
    130                 135                 140                 
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn
145                 150                 155                 160 
Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp
                165                 170                 175     
Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser
            180                 185                 190         
Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys
        195                 200                 205             
Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln
    210                 215                 220                 
Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn
225                 230                 235                 240 
Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys
                245                 250                 255     
Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg
            260                 265                 270         
Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile
        275                 280                 285             
Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr
    290                 295                 300                 
Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr
305                 310                 315                 320 
Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln
                325                 330                 335     
Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln
            340                 345                 350         
Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val
        355                 360                 365             
Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr
    370                 375                 380                 
Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr
385                 390                 395                 400 
Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn
                405                 410                 415     
Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala
            420                 425                 430         
Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr
        435                 440                 445             
Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg
    450                 455                 460                 
Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro
465                 470                 475                 480 
Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu
                485                 490                 495     
Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg
            500                 505                 510         
Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro
        515                 520                 525             
Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val
    530                 535                 540                 
Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala
545                 550                 555                 560 
His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser
                565                 570                 575     
Thr Glu Gly Glu Val Ser Ala Asp Glu Glu Gly Phe Glu Asn Leu Trp
            580                 585                 590         
Ala Thr Ala Ser Thr Phe Ile Val Leu Phe Leu Leu Ser Leu Phe Tyr
        595                 600                 605             
Ser Thr Thr Val Thr Leu Phe Lys Val Lys
    610                 615             


<210> 5425
<211> 391
<212> PRT
<213> Homo sapiens

<400> 5425
Asp Ser Pro Leu Glu Gln Ser Gly His Glu Val Gly Ile Leu Lys Glu
 1               5                  10                  15      
Thr Glu Ala Glu Asp Arg Ile Ile Lys Glu Glu Glu Ala Arg Leu Ser
            20                  25                  30          
Gly Arg Asp Met Gln Val Thr Ser Gln Pro Val Ile Ala Glu Leu Pro
        35                  40                  45              
Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn
    50                  55                  60                  
Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg
65                  70                  75                  80  
Gln Ile Glu Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly
                85                  90                  95      
Val Thr Thr Asp Glu Val Glu Ala Glu Ala Lys Glu Ser Gly Pro Thr
            100                 105                 110         
Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu
        115                 120                 125             
Gly Gln Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe
    130                 135                 140                 
Gln Gln Asn Ala Ser Ser Met Cys Gly Pro Asp Gln Asp Thr Ala Ile
145                 150                 155                 160 
Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys
                165                 170                 175     
Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser
            180                 185                 190         
Val Thr Ile Ser Trp Thr Arg Gln Asp Gly Glu Ala Val Lys Thr His
        195                 200                 205             
Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly
    210                 215                 220                 
Glu Ala Ser Ile Cys Glu Asp Asp Trp Asp Ser Gly Glu Arg Phe Thr
225                 230                 235                 240 
Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile
                245                 250                 255     
Ser Arg Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu
            260                 265                 270         
Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr
        275                 280                 285             
Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met
    290                 295                 300                 
Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro
305                 310                 315                 320 
Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu
                325                 330                 335     
Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val
            340                 345                 350         
Val Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp
        355                 360                 365             
Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser
    370                 375                 380                 
Asp Thr Ala Gly Thr Cys Tyr
385                 390     


<210> 5426
<211> 525
<212> PRT
<213> Homo sapiens

<400> 5426
Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser
 1               5                  10                  15      
Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu
            20                  25                  30          
Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe
        35                  40                  45              
Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr
    50                  55                  60                  
Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val
65                  70                  75                  80  
Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg
                85                  90                  95      
Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His
            100                 105                 110         
Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr
        115                 120                 125             
Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu
    130                 135                 140                 
Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys
145                 150                 155                 160 
Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg
                165                 170                 175     
Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr
            180                 185                 190         
Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe
        195                 200                 205             
Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr
    210                 215                 220                 
Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn
225                 230                 235                 240 
Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro
                245                 250                 255     
Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser
            260                 265                 270         
Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His
        275                 280                 285             
Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg
    290                 295                 300                 
Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu
305                 310                 315                 320 
Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly
                325                 330                 335     
Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His
            340                 345                 350         
Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala
        355                 360                 365             
His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His
    370                 375                 380                 
His Pro His Gly His His Pro His Gly His His Pro His Gly His His
385                 390                 395                 400 
Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro
                405                 410                 415     
Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly
            420                 425                 430         
Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg
        435                 440                 445             
Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu
    450                 455                 460                 
Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe
465                 470                 475                 480 
Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe
                485                 490                 495     
Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe
            500                 505                 510         
Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys
        515                 520                 525 


<210> 5427
<211> 355
<212> PRT
<213> Homo sapiens

<400> 5427
Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu
 1               5                  10                  15      
Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg
            20                  25                  30          
Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile
        35                  40                  45              
Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe
    50                  55                  60                  
Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn
65                  70                  75                  80  
Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr
                85                  90                  95      
Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe
            100                 105                 110         
Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr
        115                 120                 125             
Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe
    130                 135                 140                 
Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg
145                 150                 155                 160 
His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu
                165                 170                 175     
His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln
            180                 185                 190         
Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr
        195                 200                 205             
Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn
    210                 215                 220                 
Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu
225                 230                 235                 240 
Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu
                245                 250                 255     
Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser
            260                 265                 270         
Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly
        275                 280                 285             
Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val
    290                 295                 300                 
Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val
305                 310                 315                 320 
Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val
                325                 330                 335     
Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr
            340                 345                 350         
Cys Glu Leu
        355 


<210> 5428
<211> 911
<212> PRT
<213> Homo sapiens

<400> 5428
Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu
 1               5                  10                  15      
Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr
            20                  25                  30          
Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val
        35                  40                  45              
Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser
    50                  55                  60                  
Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn
65                  70                  75                  80  
Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe
                85                  90                  95      
Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp
            100                 105                 110         
Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile
        115                 120                 125             
Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu
    130                 135                 140                 
Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe
145                 150                 155                 160 
Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu
                165                 170                 175     
Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile
            180                 185                 190         
Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln
        195                 200                 205             
Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser
    210                 215                 220                 
Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln
225                 230                 235                 240 
Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe
                245                 250                 255     
Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val
            260                 265                 270         
Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn
        275                 280                 285             
Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg
    290                 295                 300                 
Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly
305                 310                 315                 320 
Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg
                325                 330                 335     
Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu
            340                 345                 350         
Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr
        355                 360                 365             
Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val
    370                 375                 380                 
Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met
385                 390                 395                 400 
Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile
                405                 410                 415     
Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn
            420                 425                 430         
Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser
        435                 440                 445             
Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala
    450                 455                 460                 
Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu
465                 470                 475                 480 
Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr
                485                 490                 495     
Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala
            500                 505                 510         
Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln
        515                 520                 525             
Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu
    530                 535                 540                 
Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn
545                 550                 555                 560 
His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala
                565                 570                 575     
Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln
            580                 585                 590         
Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser
        595                 600                 605             
Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile
    610                 615                 620                 
Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg
625                 630                 635                 640 
Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser
                645                 650                 655     
Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp
            660                 665                 670         
Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe
        675                 680                 685             
Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro
    690                 695                 700                 
Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg
705                 710                 715                 720 
Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala
                725                 730                 735     
Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr
            740                 745                 750         
Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala
        755                 760                 765             
Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn
    770                 775                 780                 
Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His
785                 790                 795                 800 
Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr
                805                 810                 815     
Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly
            820                 825                 830         
Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly
        835                 840                 845             
Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg
    850                 855                 860                 
Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp
865                 870                 875                 880 
His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly
                885                 890                 895     
Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe
            900                 905                 910     


<210> 5429
<211> 427
<212> PRT
<213> Homo sapiens

<400> 5429
Met His Leu Ile Asp Tyr Leu Leu Leu Leu Leu Val Gly Leu Leu Ala
 1               5                  10                  15      
Leu Ser His Gly Gln Leu His Val Glu His Asp Gly Glu Ser Cys Ser
            20                  25                  30          
Asn Ser Ser His Gln Gln Ile Leu Glu Thr Gly Glu Gly Ser Pro Ser
        35                  40                  45              
Leu Lys Ile Ala Pro Ala Asn Ala Asp Phe Ala Phe Arg Phe Tyr Tyr
    50                  55                  60                  
Leu Ile Ala Ser Glu Thr Pro Gly Lys Asn Ile Phe Phe Ser Pro Leu
65                  70                  75                  80  
Ser Ile Ser Ala Ala Tyr Ala Met Leu Ser Leu Gly Ala Cys Ser His
                85                  90                  95      
Ser Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe Asn Leu Thr Glu Leu
            100                 105                 110         
Ser Glu Ser Asp Val His Arg Gly Phe Gln His Leu Leu His Thr Leu
        115                 120                 125             
Asn Leu Pro Gly His Gly Leu Glu Thr Arg Val Gly Ser Ala Leu Phe
    130                 135                 140                 
Leu Ser His Asn Leu Lys Phe Leu Ala Lys Phe Leu Asn Asp Thr Met
145                 150                 155                 160 
Ala Val Tyr Glu Ala Lys Leu Phe His Thr Asn Phe Tyr Asp Thr Val
                165                 170                 175     
Gly Thr Ile Gln Leu Ile Asn Asp His Val Lys Lys Glu Thr Arg Gly
            180                 185                 190         
Lys Ile Val Asp Leu Val Ser Glu Leu Lys Lys Asp Val Leu Met Val
        195                 200                 205             
Leu Val Asn Tyr Ile Tyr Phe Lys Ala Leu Trp Glu Lys Pro Phe Ile
    210                 215                 220                 
Ser Ser Arg Thr Thr Pro Lys Asp Phe Tyr Val Asp Glu Asn Thr Thr
225                 230                 235                 240 
Val Arg Val Pro Met Met Leu Gln Asp Gln Glu His His Trp Tyr Leu
                245                 250                 255     
His Asp Arg Tyr Leu Pro Cys Ser Val Leu Arg Met Asp Tyr Lys Gly
            260                 265                 270         
Asp Ala Thr Val Phe Phe Ile Leu Pro Asn Gln Gly Lys Met Arg Glu
        275                 280                 285             
Ile Glu Glu Val Leu Thr Pro Glu Met Leu Met Arg Trp Asn Asn Leu
    290                 295                 300                 
Leu Arg Lys Arg Asn Phe Tyr Lys Lys Leu Glu Leu His Leu Pro Lys
305                 310                 315                 320 
Phe Ser Ile Ser Gly Ser Tyr Val Leu Asp Gln Ile Leu Pro Arg Leu
                325                 330                 335     
Gly Phe Thr Asp Leu Phe Ser Lys Trp Ala Asp Leu Ser Gly Ile Thr
            340                 345                 350         
Lys Gln Gln Lys Leu Glu Ala Ser Lys Ser Phe His Lys Ala Thr Leu
        355                 360                 365             
Asp Val Asp Glu Ala Gly Thr Glu Ala Ala Ala Ala Thr Ser Phe Ala
    370                 375                 380                 
Ile Lys Phe Phe Ser Ala Gln Thr Asn Arg His Ile Leu Arg Phe Asn
385                 390                 395                 400 
Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln Ser Val Leu
                405                 410                 415     
Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro
            420                 425         


<210> 5430
<211> 445
<212> PRT
<213> Homo sapiens

<400> 5430
Ser His Pro Gly Gly Pro Leu Gln Asp Arg Leu Cys Arg Leu Arg Val
 1               5                  10                  15      
Gln Arg Met His Leu Ile Asp Tyr Leu Leu Leu Leu Leu Val Gly Leu
            20                  25                  30          
Leu Ala Leu Ser His Gly Gln Leu His Val Glu His Asp Gly Glu Ser
        35                  40                  45              
Cys Ser Asn Ser Ser His Gln Gln Ile Leu Glu Thr Gly Glu Gly Ser
    50                  55                  60                  
Pro Ser Leu Lys Ile Ala Pro Ala Asn Ala Asp Phe Ala Phe Arg Phe
65                  70                  75                  80  
Tyr Tyr Leu Ile Ala Ser Glu Thr Pro Gly Lys Asn Ile Phe Phe Ser
                85                  90                  95      
Pro Leu Ser Ile Ser Ala Ala Tyr Ala Met Leu Ser Leu Gly Ala Cys
            100                 105                 110         
Ser His Ser Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe Asn Leu Thr
        115                 120                 125             
Glu Leu Ser Glu Ser Asp Val His Arg Gly Phe Gln His Leu Leu His
    130                 135                 140                 
Thr Leu Asn Leu Pro Gly His Gly Leu Glu Thr Arg Val Gly Ser Ala
145                 150                 155                 160 
Leu Phe Leu Ser His Asn Leu Lys Phe Leu Ala Lys Phe Leu Asn Asp
                165                 170                 175     
Thr Met Ala Val Tyr Glu Ala Lys Leu Phe His Thr Asn Phe Tyr Asp
            180                 185                 190         
Thr Val Gly Thr Ile Gln Leu Ile Asn Asp His Val Lys Lys Glu Thr
        195                 200                 205             
Arg Gly Lys Ile Val Asp Leu Val Ser Glu Leu Lys Lys Asp Val Leu
    210                 215                 220                 
Met Val Leu Val Asn Tyr Ile Tyr Phe Lys Ala Leu Trp Glu Lys Pro
225                 230                 235                 240 
Phe Ile Ser Ser Arg Thr Thr Pro Lys Asp Phe Tyr Val Asp Glu Asn
                245                 250                 255     
Thr Thr Val Arg Val Pro Met Met Leu Gln Asp Gln Glu His His Trp
            260                 265                 270         
Tyr Leu His Asp Arg Tyr Leu Pro Cys Ser Val Leu Arg Met Asp Tyr
        275                 280                 285             
Lys Gly Asp Ala Thr Val Phe Phe Ile Leu Pro Asn Gln Gly Lys Met
    290                 295                 300                 
Arg Glu Ile Glu Glu Val Leu Thr Pro Glu Met Leu Met Arg Trp Asn
305                 310                 315                 320 
Asn Leu Leu Arg Lys Arg Asn Phe Tyr Lys Lys Leu Glu Leu His Leu
                325                 330                 335     
Pro Lys Phe Ser Ile Ser Gly Ser Tyr Val Leu Asp Gln Ile Leu Pro
            340                 345                 350         
Arg Leu Gly Phe Thr Asp Leu Phe Ser Lys Trp Ala Asp Leu Ser Gly
        355                 360                 365             
Ile Thr Lys Gln Gln Lys Leu Glu Ala Ser Lys Ser Phe His Lys Ala
    370                 375                 380                 
Thr Leu Asp Val Asp Glu Ala Gly Thr Glu Ala Ala Ala Ala Thr Ser
385                 390                 395                 400 
Phe Ala Ile Lys Phe Phe Ser Ala Gln Thr Asn Arg His Ile Leu Arg
                405                 410                 415     
Phe Asn Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln Ser
            420                 425                 430         
Val Leu Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro
        435                 440                 445 


<210> 5431
<211> 414
<212> PRT
<213> Homo sapiens

<400> 5431
Leu Leu Leu Val Gly Leu Leu Ala Leu Ser His Gly Gln Leu His Val
 1               5                  10                  15      
Glu His Asp Gly Glu Ser Cys Ser Asn Ser Ser His Gln Gln Ile Leu
            20                  25                  30          
Glu Thr Gly Glu Gly Ser Pro Ser Leu Lys Ile Ala Pro Ala Asn Ala
        35                  40                  45              
Asp Phe Ala Phe Arg Phe Tyr Tyr Leu Ile Ala Ser Glu Thr Pro Gly
    50                  55                  60                  
Lys Asn Ile Phe Phe Ser Pro Leu Ser Ile Ser Ala Ala Tyr Ala Met
65                  70                  75                  80  
Leu Ser Leu Gly Ala Cys Ser His Ser Arg Ser Gln Ile Leu Glu Gly
                85                  90                  95      
Leu Gly Phe Asn Leu Thr Glu Leu Ser Glu Ser Asp Val His Arg Gly
            100                 105                 110         
Phe Gln His Leu Leu His Thr Leu Asn Leu Pro Gly His Gly Leu Glu
        115                 120                 125             
Thr Arg Val Gly Ser Ala Leu Phe Leu Ser His Asn Leu Lys Phe Leu
    130                 135                 140                 
Ala Lys Phe Leu Asn Asp Thr Met Ala Val Tyr Glu Ala Lys Leu Phe
145                 150                 155                 160 
His Thr Asn Phe Tyr Asp Thr Val Gly Thr Ile Gln Leu Ile Asn Asp
                165                 170                 175     
His Val Lys Lys Glu Thr Arg Gly Lys Ile Val Asp Leu Val Ser Glu
            180                 185                 190         
Leu Lys Lys Asp Val Leu Met Val Leu Val Asn Tyr Ile Tyr Phe Lys
        195                 200                 205             
Ala Lys Trp Glu Thr Ser Phe Asn His Lys Gly Thr Gln Glu Gln Asp
    210                 215                 220                 
Phe Tyr Val Thr Ser Glu Thr Val Val Arg Val Pro Met Met Ser Arg
225                 230                 235                 240 
Glu Asp Gln Tyr His Tyr Leu Leu Asp Arg Asn Leu Ser Cys Arg Val
                245                 250                 255     
Val Gly Val Pro Tyr Gln Gly Asn Ala Thr Ala Leu Phe Ile Leu Pro
            260                 265                 270         
Ser Glu Gly Lys Met Gln Gln Val Glu Asn Gly Leu Ser Glu Lys Thr
        275                 280                 285             
Leu Arg Lys Trp Leu Lys Met Phe Lys Lys Arg Gln Leu Glu Leu Tyr
    290                 295                 300                 
Leu Pro Lys Phe Ser Ile Glu Gly Ser Tyr Gln Leu Glu Lys Val Leu
305                 310                 315                 320 
Pro Ser Leu Gly Ile Ser Asn Val Phe Thr Ser His Ala Asp Leu Ser
                325                 330                 335     
Gly Ile Ser Asn His Ser Asn Ile Gln Val Ser Glu Val Val His Lys
            340                 345                 350         
Ala Val Leu Asp Val Phe Glu Glu Gly Thr Glu Ala Ser Ala Ala Thr
        355                 360                 365             
Ala Val Lys Ile Thr Leu Leu Ser Ala Leu Val Glu Thr Arg Thr Ile
    370                 375                 380                 
Val Arg Phe Asn Arg Pro Phe Leu Met Ile Ile Val Pro Thr Asp Thr
385                 390                 395                 400 
Gln Asn Ile Phe Phe Met Ser Lys Val Thr Asn Pro Lys Gln
                405                 410                 


<210> 5432
<211> 2446
<212> PRT
<213> Homo sapiens

<400> 5432
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Glu Val Pro Gln Leu Thr Asp Leu Ser Phe Val Asp Ile Thr Asp
1265                1270                1275                1280
Ser Ser Ile Gly Leu Arg Trp Thr Pro Leu Asn Ser Ser Thr Ile Ile
                1285                1290                1295    
Gly Tyr Arg Ile Thr Val Val Ala Ala Gly Glu Gly Ile Pro Ile Phe
            1300                1305                1310        
Glu Asp Phe Val Asp Ser Ser Val Gly Tyr Tyr Thr Val Thr Gly Leu
        1315                1320                1325            
Glu Pro Gly Ile Asp Tyr Asp Ile Ser Val Ile Thr Leu Ile Asn Gly
    1330                1335                1340                
Gly Glu Ser Ala Pro Thr Thr Leu Thr Gln Gln Thr Ala Val Pro Pro
1345                1350                1355                1360
Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro Asp Thr Met Arg Val
                1365                1370                1375    
Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr Asn Phe Leu Val Arg
            1380                1385                1390        
Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala Glu Leu Ser Ile Ser
        1395                1400                1405            
Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu Leu Pro Gly Thr Glu
    1410                1415                1420                
Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln His Glu Ser Thr Pro
1425                1430                1435                1440
Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser Pro Thr Gly Ile Asp
                1445                1450                1455    
Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val His Trp Ile Ala Pro
            1460                1465                1470        
Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His His Pro Glu His Phe
        1475                1480                1485            
Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His Ser Arg Asn Ser Ile
    1490                1495                1500                
Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr Val Val Ser Ile Val
1505                1510                1515                1520
Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu Ile Gly Gln Gln Ser
                1525                1530                1535    
Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro
            1540                1545                1550        
Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr
        1555                1560                1565            
Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu
    1570                1575                1580                
Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys
1585                1590                1595                1600
Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly
                1605                1610                1615    
Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu
            1620                1625                1630        
Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp Val Gln Asp Asn Ser
        1635                1640                1645            
Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro Val Thr Gly Tyr Arg
    1650                1655                1660                
Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro Thr Lys Thr Lys Thr
1665                1670                1675                1680
Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu Gly Leu Gln Pro Thr
                1685                1690                1695    
Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn Pro Ser Gly Glu Ser
            1700                1705                1710        
Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile Asp Arg Pro Lys Gly
        1715                1720                1725            
Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile Lys Ile Ala Trp Glu
    1730                1735                1740                
Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val Thr Tyr Ser Ser Pro
1745                1750                1755                1760
Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro Asp Gly Glu Glu Asp
                1765                1770                1775    
Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser Glu Tyr Thr Val Ser
            1780                1785                1790        
Val Val Ala Leu His Asp Asp Met Glu Ser Gln Pro Leu Ile Gly Thr
        1795                1800                1805            
Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu Lys Phe Thr Gln Val
    1810                1815                1820                
Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro Pro Asn Val Gln Leu
1825                1830                1835                1840
Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu Lys Thr Gly Pro Met
                1845                1850                1855    
Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser Val Val Val Ser Gly
            1860                1865                1870        
Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp
        1875                1880                1885            
Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val Thr Thr Leu Glu Asn
    1890                1895                1900                
Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr
1905                1910                1915                1920
Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln
                1925                1930                1935    
Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile
            1940                1945                1950        
Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr
        1955                1960                1965            
Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser
    1970                1975                1980                
Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu
1985                1990                1995                2000
Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Pro
                2005                2010                2015    
Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly
            2020                2025                2030        
Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu
        2035                2040                2045            
Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val
    2050                2055                2060                
Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys
2065                2070                2075                2080
Lys Thr Asp Glu Leu Pro Gln Leu Val Thr Leu Pro His Pro Asn Leu
                2085                2090                2095    
His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr Val Gln Lys Thr Pro
            2100                2105                2110        
Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn Gly Ile Gln Leu Pro
        2115                2120                2125            
Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln Gln Met Ile Phe Glu
    2130                2135                2140                
Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr Thr Ala Thr Pro Ile
2145                2150                2155                2160
Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val Gly Gln Glu Ala Leu
                2165                2170                2175    
Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser Glu Tyr
            2180                2185                2190        
Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro Leu Gln Phe
        2195                2200                2205            
Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu Thr Arg
    2210                2215                2220                
Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys Asp Gln Gln Arg
2225                2230                2235                2240
His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn Ser Val Asn Glu
                2245                2250                2255    
Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp Pro Tyr Thr Val
            2260                2265                2270        
Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met Ser Glu Ser Gly
        2275                2280                2285            
Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser Gly His Phe Arg
    2290                2295                2300                
Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val Asn Tyr Lys Ile
2305                2310                2315                2320
Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met Met Ser Cys
                2325                2330                2335    
Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp Pro His Glu
            2340                2345                2350        
Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly Glu Gln Trp
        2355                2360                2365            
Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly
    2370                2375                2380                
Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Gly Glu Pro
2385                2390                2395                2400
Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr Ser Gln Arg
                2405                2410                2415    
Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile Glu Cys Phe
            2420                2425                2430        
Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser Arg Glu
        2435                2440                2445    


<210> 5433
<211> 2386
<212> PRT
<213> Homo sapiens

<400> 5433
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Glu Val Pro Gln Leu Thr Asp Leu Ser Phe Val Asp Ile Thr Asp
1265                1270                1275                1280
Ser Ser Ile Gly Leu Arg Trp Thr Pro Leu Asn Ser Ser Thr Ile Ile
                1285                1290                1295    
Gly Tyr Arg Ile Thr Val Val Ala Ala Gly Glu Gly Ile Pro Ile Phe
            1300                1305                1310        
Glu Asp Phe Val Asp Ser Ser Val Gly Tyr Tyr Thr Val Thr Gly Leu
        1315                1320                1325            
Glu Pro Gly Ile Asp Tyr Asp Ile Ser Val Ile Thr Leu Ile Asn Gly
    1330                1335                1340                
Gly Glu Ser Ala Pro Thr Thr Leu Thr Gln Gln Thr Ala Val Pro Pro
1345                1350                1355                1360
Pro Thr Asp Leu Arg Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile
            1620                1625                1630        
Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile
        1635                1640                1645            
Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val
    1650                1655                1660                
Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro
1665                1670                1675                1680
Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser
                1685                1690                1695    
Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln
            1700                1705                1710        
Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu
        1715                1720                1725            
Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro
    1730                1735                1740                
Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu
1745                1750                1755                1760
Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser
                1765                1770                1775    
Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val
            1780                1785                1790        
Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val
        1795                1800                1805            
Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp
    1810                1815                1820                
Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr
1825                1830                1835                1840
Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro
                1845                1850                1855    
Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly
            1860                1865                1870        
Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp
        1875                1880                1885            
Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp
    1890                1895                1900                
Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu
1905                1910                1915                1920
Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys
                1925                1930                1935    
Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg
            1940                1945                1950        
Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu
        1955                1960                1965            
Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro
    1970                1975                1980                
Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro Gln Leu Val Thr Leu
1985                1990                1995                2000
Pro His Pro Asn Leu His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr
                2005                2010                2015    
Val Gln Lys Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn
            2020                2025                2030        
Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln
        2035                2040                2045            
Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr
    2050                2055                2060                
Thr Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val
2065                2070                2075                2080
Gly Glu Glu Ile Gln Ile Gly His Ile Pro Arg Glu Asp Val Asp Tyr
                2085                2090                2095    
His Leu Tyr Pro His Gly Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly
            2100                2105                2110        
Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp
        2115                2120                2125            
Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu
    2130                2135                2140                
Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr
2145                2150                2155                2160
Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys
                2165                2170                2175    
Asp Gln Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn
            2180                2185                2190        
Ser Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp
        2195                2200                2205            
Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met
    2210                2215                2220                
Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser
2225                2230                2235                2240
Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val
                2245                2250                2255    
Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln
            2260                2265                2270        
Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys
        2275                2280                2285            
Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val
    2290                2295                2300                
Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr
2305                2310                2315                2320
Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro
                2325                2330                2335    
Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln
            2340                2345                2350        
Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro
        2355                2360                2365            
Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser
    2370                2375                2380                
Arg Glu
2385    


<210> 5434
<211> 2240
<212> PRT
<213> Homo sapiens

<400> 5434
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Thr Ile
            1620                1625                1630        
Pro Ala Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro Thr Ser Leu
        1635                1640                1645            
Ser Ala Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr Arg Val
    1650                1655                1660                
Arg Val Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile Asn Leu
1665                1670                1675                1680
Ala Pro Asp Ser Ser Ser Val Val Val Ser Gly Leu Met Val Ala Thr
                1685                1690                1695    
Lys Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg
            1700                1705                1710        
Pro Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro Pro Arg
        1715                1720                1725            
Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp
    1730                1735                1740                
Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala Val Pro
1745                1750                1755                1760
Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val Arg
                1765                1770                1775    
Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr
            1780                1785                1790        
Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile Asp
        1795                1800                1805            
Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr
    1810                1815                1820                
Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala Arg Ile
1825                1830                1835                1840
Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu
                1845                1850                1855    
Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile Thr Gly
            1860                1865                1870        
Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn
        1875                1880                1885            
Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr Val Gln Lys
    1890                1895                1900                
Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn Gly Ile Gln
1905                1910                1915                1920
Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln Gln Met Ile
                1925                1930                1935    
Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr Thr Ala Thr
            1940                1945                1950        
Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val Gly Gln Glu
        1955                1960                1965            
Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser
    1970                1975                1980                
Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro Leu
1985                1990                1995                2000
Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu
                2005                2010                2015    
Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys Asp Gln
            2020                2025                2030        
Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn Ser Val
        2035                2040                2045            
Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp Pro Tyr
    2050                2055                2060                
Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met Ser Glu
2065                2070                2075                2080
Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser Gly His
                2085                2090                2095    
Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val Asn Tyr
            2100                2105                2110        
Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met Met
        2115                2120                2125            
Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp Pro
    2130                2135                2140                
His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly Glu
2145                2150                2155                2160
Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys Phe
                2165                2170                2175    
Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Gly
            2180                2185                2190        
Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr Ser
        2195                2200                2205            
Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile Glu
    2210                2215                2220                
Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser Arg Glu
2225                2230                2235                2240


<210> 5435
<211> 2031
<212> PRT
<213> Homo sapiens

<400> 5435
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile
            1620                1625                1630        
Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile
        1635                1640                1645            
Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val
    1650                1655                1660                
Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro
1665                1670                1675                1680
Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser
                1685                1690                1695    
Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln
            1700                1705                1710        
Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu
        1715                1720                1725            
Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro
    1730                1735                1740                
Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu
1745                1750                1755                1760
Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser
                1765                1770                1775    
Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val
            1780                1785                1790        
Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val
        1795                1800                1805            
Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp
    1810                1815                1820                
Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr
1825                1830                1835                1840
Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro
                1845                1850                1855    
Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly
            1860                1865                1870        
Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp
        1875                1880                1885            
Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp
    1890                1895                1900                
Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu
1905                1910                1915                1920
Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys
                1925                1930                1935    
Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg
            1940                1945                1950        
Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu
        1955                1960                1965            
Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro
    1970                1975                1980                
Leu Ile Gly Arg Lys Lys Thr Gly Gln Glu Ala Leu Ser Gln Thr Thr
1985                1990                1995                2000
Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser Glu Tyr Ile Ile Ser Cys
                2005                2010                2015    
His Pro Val Gly Thr Asp Glu Glu Pro Leu Gln Ser Thr Lys Ala
            2020                2025                2030    


<210> 5436
<211> 2296
<212> PRT
<213> Homo sapiens

<400> 5436
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Thr Ile
            1620                1625                1630        
Pro Ala Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro Thr Ser Leu
        1635                1640                1645            
Ser Ala Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr Arg Val
    1650                1655                1660                
Arg Val Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile Asn Leu
1665                1670                1675                1680
Ala Pro Asp Ser Ser Ser Val Val Val Ser Gly Leu Met Val Ala Thr
                1685                1690                1695    
Lys Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg
            1700                1705                1710        
Pro Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro Pro Arg
        1715                1720                1725            
Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp
    1730                1735                1740                
Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala Val Pro
1745                1750                1755                1760
Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val Arg
                1765                1770                1775    
Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr
            1780                1785                1790        
Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile Asp
        1795                1800                1805            
Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr
    1810                1815                1820                
Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala Arg Ile
1825                1830                1835                1840
Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu
                1845                1850                1855    
Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile Thr Gly
            1860                1865                1870        
Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn
        1875                1880                1885            
Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu
    1890                1895                1900                
Pro Gln Leu Val Thr Leu Pro His Pro Asn Leu His Gly Pro Glu Ile
1905                1910                1915                1920
Leu Asp Val Pro Ser Thr Val Gln Lys Thr Pro Phe Val Thr His Pro
                1925                1930                1935    
Gly Tyr Asp Thr Gly Asn Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln
            1940                1945                1950        
Gln Pro Ser Val Gly Gln Gln Met Ile Phe Glu Glu His Gly Phe Arg
        1955                1960                1965            
Arg Thr Thr Pro Pro Thr Thr Ala Thr Pro Ile Arg His Arg Pro Arg
    1970                1975                1980                
Pro Tyr Pro Pro Asn Val Gly Glu Glu Ile Gln Ile Gly His Ile Pro
1985                1990                1995                2000
Arg Glu Asp Val Asp Tyr His Leu Tyr Pro His Gly Pro Gly Leu Asn
                2005                2010                2015    
Pro Asn Ala Ser Thr Gly Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser
            2020                2025                2030        
Trp Ala Pro Phe Gln Asp Thr Ser Glu Tyr Ile Ile Ser Cys His Pro
        2035                2040                2045            
Val Gly Thr Asp Glu Glu Pro Leu Gln Phe Arg Val Pro Gly Thr Ser
    2050                2055                2060                
Thr Ser Ala Thr Leu Thr Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile
2065                2070                2075                2080
Ile Val Glu Ala Leu Lys Asp Gln Gln Arg His Lys Val Arg Glu Glu
                2085                2090                2095    
Val Val Thr Val Gly Asn Ser Val Asn Glu Gly Leu Asn Gln Pro Thr
            2100                2105                2110        
Asp Asp Ser Cys Phe Asp Pro Tyr Thr Val Ser His Tyr Ala Val Gly
        2115                2120                2125            
Asp Glu Trp Glu Arg Met Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln
    2130                2135                2140                
Cys Leu Gly Phe Gly Ser Gly His Phe Arg Cys Asp Ser Ser Arg Trp
2145                2150                2155                2160
Cys His Asp Asn Gly Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg
                2165                2170                2175    
Gln Gly Glu Asn Gly Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly
            2180                2185                2190        
Lys Gly Glu Phe Lys Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp
        2195                2200                2205            
Gly Lys Thr Tyr His Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly
    2210                2215                2220                
Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys
2225                2230                2235                2240
Asp Asn Cys Arg Arg Pro Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr
                2245                2250                2255    
Gly Gln Ser Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn
            2260                2265                2270        
Thr Asn Val Asn Cys Pro Ile Glu Cys Phe Met Pro Leu Asp Val Gln
        2275                2280                2285            
Ala Asp Arg Glu Asp Ser Arg Glu
    2290                2295    


<210> 5437
<211> 2176
<212> PRT
<213> Homo sapiens

<400> 5437
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Thr Ile
            1620                1625                1630        
Pro Ala Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro Thr Ser Leu
        1635                1640                1645            
Ser Ala Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr Arg Val
    1650                1655                1660                
Arg Val Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile Asn Leu
1665                1670                1675                1680
Ala Pro Asp Ser Ser Ser Val Val Val Ser Gly Leu Met Val Ala Thr
                1685                1690                1695    
Lys Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg
            1700                1705                1710        
Pro Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro Pro Arg
        1715                1720                1725            
Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp
    1730                1735                1740                
Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala Val Pro
1745                1750                1755                1760
Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp Val Arg
                1765                1770                1775    
Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr
            1780                1785                1790        
Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile Asp
        1795                1800                1805            
Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr
    1810                1815                1820                
Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala Arg Ile
1825                1830                1835                1840
Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu
                1845                1850                1855    
Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile Thr Gly
            1860                1865                1870        
Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn
        1875                1880                1885            
Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr Gly Gln Glu
    1890                1895                1900                
Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser
1905                1910                1915                1920
Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro Leu
                1925                1930                1935    
Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu
            1940                1945                1950        
Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys Asp Gln
        1955                1960                1965            
Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn Ser Val
    1970                1975                1980                
Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp Pro Tyr
1985                1990                1995                2000
Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met Ser Glu
                2005                2010                2015    
Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser Gly His
            2020                2025                2030        
Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val Asn Tyr
        2035                2040                2045            
Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met Met
    2050                2055                2060                
Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys Asp Pro
2065                2070                2075                2080
His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val Gly Glu
                2085                2090                2095    
Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr Cys Phe
            2100                2105                2110        
Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Gly
        2115                2120                2125            
Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr Ser
    2130                2135                2140                
Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile Glu
2145                2150                2155                2160
Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser Arg Glu
                2165                2170                2175    


<210> 5438
<211> 2355
<212> PRT
<213> Homo sapiens

<400> 5438
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile
            1620                1625                1630        
Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile
        1635                1640                1645            
Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val
    1650                1655                1660                
Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro
1665                1670                1675                1680
Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser
                1685                1690                1695    
Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln
            1700                1705                1710        
Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu
        1715                1720                1725            
Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro
    1730                1735                1740                
Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu
1745                1750                1755                1760
Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser
                1765                1770                1775    
Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val
            1780                1785                1790        
Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val
        1795                1800                1805            
Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp
    1810                1815                1820                
Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr
1825                1830                1835                1840
Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro
                1845                1850                1855    
Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly
            1860                1865                1870        
Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp
        1875                1880                1885            
Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp
    1890                1895                1900                
Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu
1905                1910                1915                1920
Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys
                1925                1930                1935    
Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg
            1940                1945                1950        
Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu
        1955                1960                1965            
Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro
    1970                1975                1980                
Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro Gln Leu Val Thr Leu
1985                1990                1995                2000
Pro His Pro Asn Leu His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr
                2005                2010                2015    
Val Gln Lys Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn
            2020                2025                2030        
Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln
        2035                2040                2045            
Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr
    2050                2055                2060                
Thr Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val
2065                2070                2075                2080
Gly Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln
                2085                2090                2095    
Asp Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu
            2100                2105                2110        
Glu Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu
        2115                2120                2125            
Thr Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu
    2130                2135                2140                
Lys Asp Gln Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly
2145                2150                2155                2160
Asn Ser Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe
                2165                2170                2175    
Asp Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg
            2180                2185                2190        
Met Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly
        2195                2200                2205            
Ser Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly
    2210                2215                2220                
Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly
2225                2230                2235                2240
Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys
                2245                2250                2255    
Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His
            2260                2265                2270        
Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys
        2275                2280                2285            
Thr Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg
    2290                2295                2300                
Pro Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn
2305                2310                2315                2320
Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys
                2325                2330                2335    
Pro Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp
            2340                2345                2350        
Ser Arg Glu
        2355


<210> 5439
<211> 2386
<212> PRT
<213> Homo sapiens

<400> 5439
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile
            1620                1625                1630        
Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile
        1635                1640                1645            
Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val
    1650                1655                1660                
Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro
1665                1670                1675                1680
Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser
                1685                1690                1695    
Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln
            1700                1705                1710        
Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu
        1715                1720                1725            
Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro
    1730                1735                1740                
Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu
1745                1750                1755                1760
Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser
                1765                1770                1775    
Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val
            1780                1785                1790        
Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val
        1795                1800                1805            
Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp
    1810                1815                1820                
Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr
1825                1830                1835                1840
Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro
                1845                1850                1855    
Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly
            1860                1865                1870        
Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp
        1875                1880                1885            
Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp
    1890                1895                1900                
Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu
1905                1910                1915                1920
Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys
                1925                1930                1935    
Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg
            1940                1945                1950        
Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu
        1955                1960                1965            
Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro
    1970                1975                1980                
Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro Gln Leu Val Thr Leu
1985                1990                1995                2000
Pro His Pro Asn Leu His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr
                2005                2010                2015    
Val Gln Lys Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn
            2020                2025                2030        
Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln
        2035                2040                2045            
Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr
    2050                2055                2060                
Thr Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val
2065                2070                2075                2080
Gly Glu Glu Ile Gln Ile Gly His Ile Pro Arg Glu Asp Val Asp Tyr
                2085                2090                2095    
His Leu Tyr Pro His Gly Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly
            2100                2105                2110        
Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp
        2115                2120                2125            
Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu
    2130                2135                2140                
Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr
2145                2150                2155                2160
Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys
                2165                2170                2175    
Asp Gln Gln Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn
            2180                2185                2190        
Ser Val Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp
        2195                2200                2205            
Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met
    2210                2215                2220                
Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser
2225                2230                2235                2240
Gly His Phe Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val
                2245                2250                2255    
Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln
            2260                2265                2270        
Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys Cys
        2275                2280                2285            
Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His Val
    2290                2295                2300                
Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys Thr
2305                2310                2315                2320
Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg Pro
                2325                2330                2335    
Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln
            2340                2345                2350        
Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro
        2355                2360                2365            
Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp Ser
    2370                2375                2380                
Arg Glu
2385    


<210> 5440
<211> 2184
<212> PRT
<213> Homo sapiens

<400> 5440
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile
            1620                1625                1630        
Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile
        1635                1640                1645            
Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val
    1650                1655                1660                
Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro
1665                1670                1675                1680
Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser
                1685                1690                1695    
Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln
            1700                1705                1710        
Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu
        1715                1720                1725            
Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro
    1730                1735                1740                
Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu
1745                1750                1755                1760
Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser
                1765                1770                1775    
Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val
            1780                1785                1790        
Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val
        1795                1800                1805            
Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp
    1810                1815                1820                
Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr
1825                1830                1835                1840
Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro
                1845                1850                1855    
Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly
            1860                1865                1870        
Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp
        1875                1880                1885            
Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp
    1890                1895                1900                
Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu
1905                1910                1915                1920
Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys
                1925                1930                1935    
Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg
            1940                1945                1950        
Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu
        1955                1960                1965            
Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro
    1970                1975                1980                
Leu Ile Gly Arg Lys Lys Thr Val Asn Glu Gly Leu Asn Gln Pro Thr
1985                1990                1995                2000
Asp Asp Ser Cys Phe Asp Pro Tyr Thr Val Ser His Tyr Ala Val Gly
                2005                2010                2015    
Asp Glu Trp Glu Arg Met Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln
            2020                2025                2030        
Cys Leu Gly Phe Gly Ser Gly His Phe Arg Cys Asp Ser Ser Arg Trp
        2035                2040                2045            
Cys His Asp Asn Gly Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg
    2050                2055                2060                
Gln Gly Glu Asn Gly Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly
2065                2070                2075                2080
Lys Gly Glu Phe Lys Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp
                2085                2090                2095    
Gly Lys Thr Tyr His Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly
            2100                2105                2110        
Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys
        2115                2120                2125            
Asp Asn Cys Arg Arg Pro Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr
    2130                2135                2140                
Gly Gln Ser Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn
2145                2150                2155                2160
Thr Asn Val Asn Cys Pro Ile Glu Cys Phe Met Pro Leu Asp Val Gln
                2165                2170                2175    
Ala Asp Arg Glu Asp Ser Arg Glu
            2180                


<210> 5441
<211> 2211
<212> PRT
<213> Homo sapiens

<400> 5441
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly
        355                 360                 365             
Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu
    370                 375                 380                 
Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385                 390                 395                 400 
Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser Asn
                405                 410                 415     
Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr
            420                 425                 430         
Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr
        435                 440                 445             
Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala
    450                 455                 460                 
Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile
465                 470                 475                 480 
Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys
                485                 490                 495     
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser
            500                 505                 510         
Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn
        515                 520                 525             
Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr
    530                 535                 540                 
Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln
545                 550                 555                 560 
Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp
                565                 570                 575     
Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg
            580                 585                 590         
Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser
        595                 600                 605             
Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn
    610                 615                 620                 
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys
625                 630                 635                 640 
Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu
                645                 650                 655     
Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys
            660                 665                 670         
Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly
        675                 680                 685             
His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr
    690                 695                 700                 
Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro
705                 710                 715                 720 
Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe
                725                 730                 735     
Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val
            740                 745                 750         
Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
        755                 760                 765             
Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg
    770                 775                 780                 
Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser
785                 790                 795                 800 
Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp
                805                 810                 815     
Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser
            820                 825                 830         
Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser
        835                 840                 845             
Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser
    850                 855                 860                 
Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile
865                 870                 875                 880 
Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln
                885                 890                 895     
Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp
            900                 905                 910         
Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr
        915                 920                 925             
Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val
    930                 935                 940                 
Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr
945                 950                 955                 960 
Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys
                965                 970                 975     
Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln
            980                 985                 990         
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu
        995                 1000                1005            
Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln Ile
    1010                1015                1020                
Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg
1025                1030                1035                1040
Gln Tyr Asn Val Gly Pro Ser Val Ser Lys Tyr Pro Leu Arg Asn Leu
                1045                1050                1055    
Gln Pro Ala Ser Glu Tyr Thr Val Ser Leu Val Ala Ile Lys Gly Asn
            1060                1065                1070        
Gln Glu Ser Pro Lys Ala Thr Gly Val Phe Thr Thr Leu Gln Pro Gly
        1075                1080                1085            
Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val Thr Glu Thr Thr Ile Val
    1090                1095                1100                
Ile Thr Trp Thr Pro Ala Pro Arg Ile Gly Phe Lys Leu Gly Val Arg
1105                1110                1115                1120
Pro Ser Gln Gly Gly Glu Ala Pro Arg Glu Val Thr Ser Asp Ser Gly
                1125                1130                1135    
Ser Ile Val Val Ser Gly Leu Thr Pro Gly Val Glu Tyr Val Tyr Thr
            1140                1145                1150        
Ile Gln Val Leu Arg Asp Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
        1155                1160                1165            
Lys Val Val Thr Pro Leu Ser Pro Pro Thr Asn Leu His Leu Glu Ala
    1170                1175                1180                
Asn Pro Asp Thr Gly Val Leu Thr Val Ser Trp Glu Arg Ser Thr Thr
1185                1190                1195                1200
Pro Asp Ile Thr Gly Tyr Arg Ile Thr Thr Thr Pro Thr Asn Gly Gln
                1205                1210                1215    
Gln Gly Asn Ser Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys
            1220                1225                1230        
Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr
        1235                1240                1245            
Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile Ile
    1250                1255                1260                
Pro Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro
1265                1270                1275                1280
Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro Ser Ile Asp Leu Thr
                1285                1290                1295    
Asn Phe Leu Val Arg Tyr Ser Pro Val Lys Asn Glu Glu Asp Val Ala
            1300                1305                1310        
Glu Leu Ser Ile Ser Pro Ser Asp Asn Ala Val Val Leu Thr Asn Leu
        1315                1320                1325            
Leu Pro Gly Thr Glu Tyr Val Val Ser Val Ser Ser Val Tyr Glu Gln
    1330                1335                1340                
His Glu Ser Thr Pro Leu Arg Gly Arg Gln Lys Thr Gly Leu Asp Ser
1345                1350                1355                1360
Pro Thr Gly Ile Asp Phe Ser Asp Ile Thr Ala Asn Ser Phe Thr Val
                1365                1370                1375    
His Trp Ile Ala Pro Arg Ala Thr Ile Thr Gly Tyr Arg Ile Arg His
            1380                1385                1390        
His Pro Glu His Phe Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His
        1395                1400                1405            
Ser Arg Asn Ser Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
    1410                1415                1420                
Val Val Ser Ile Val Ala Leu Asn Gly Arg Glu Glu Ser Pro Leu Leu
1425                1430                1435                1440
Ile Gly Gln Gln Ser Thr Val Ser Asp Val Pro Arg Asp Leu Glu Val
                1445                1450                1455    
Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala
            1460                1465                1470        
Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn
        1475                1480                1485            
Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr
    1490                1495                1500                
Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala
1505                1510                1515                1520
Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile
                1525                1530                1535    
Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln Val Thr Asp
            1540                1545                1550        
Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser Ser Ser Pro
        1555                1560                1565            
Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro Gly Pro
    1570                1575                1580                
Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met Thr Ile Glu
1585                1590                1595                1600
Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr Ala Gln Asn
                1605                1610                1615    
Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val Thr Asn Ile
            1620                1625                1630        
Asp Arg Pro Lys Gly Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile
        1635                1640                1645            
Lys Ile Ala Trp Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr Arg Val
    1650                1655                1660                
Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro
1665                1670                1675                1680
Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Leu Arg Pro Gly Ser
                1685                1690                1695    
Glu Tyr Thr Val Ser Val Val Ala Leu His Asp Asp Met Glu Ser Gln
            1700                1705                1710        
Pro Leu Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp Leu
        1715                1720                1725            
Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro
    1730                1735                1740                
Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu
1745                1750                1755                1760
Lys Thr Gly Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser
                1765                1770                1775    
Val Val Val Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val
            1780                1785                1790        
Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val
        1795                1800                1805            
Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp
    1810                1815                1820                
Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr
1825                1830                1835                1840
Ile Thr Gly Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro
                1845                1850                1855    
Ile Gln Arg Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly
            1860                1865                1870        
Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp
        1875                1880                1885            
Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp
    1890                1895                1900                
Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu
1905                1910                1915                1920
Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys
                1925                1930                1935    
Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg
            1940                1945                1950        
Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu
        1955                1960                1965            
Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro
    1970                1975                1980                
Leu Ile Gly Arg Lys Lys Thr Gly Gln Glu Ala Leu Ser Gln Thr Thr
1985                1990                1995                2000
Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser Glu Tyr Ile Ile Ser Cys
                2005                2010                2015    
His Pro Val Gly Thr Asp Glu Glu Pro Leu Gln Phe Arg Val Pro Gly
            2020                2025                2030        
Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu Thr Arg Gly Ala Thr Tyr
        2035                2040                2045            
Asn Ile Ile Val Glu Ala Leu Lys Asp Gln Gln Arg His Lys Val Arg
    2050                2055                2060                
Glu Glu Val Val Thr Val Gly Asn Ser Arg Trp Cys His Asp Asn Gly
2065                2070                2075                2080
Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly
                2085                2090                2095    
Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu Phe Lys
            2100                2105                2110        
Cys Asp Pro His Glu Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His
        2115                2120                2125            
Val Gly Glu Gln Trp Gln Lys Glu Tyr Leu Gly Ala Ile Cys Ser Cys
    2130                2135                2140                
Thr Cys Phe Gly Gly Gln Arg Gly Trp Arg Cys Asp Asn Cys Arg Arg
2145                2150                2155                2160
Pro Gly Gly Glu Pro Ser Pro Glu Gly Thr Thr Gly Gln Ser Tyr Asn
                2165                2170                2175    
Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn Thr Asn Val Asn Cys
            2180                2185                2190        
Pro Ile Glu Cys Phe Met Pro Leu Asp Val Gln Ala Asp Arg Glu Asp
        2195                2200                2205            
Ser Arg Glu
    2210    


<210> 5442
<211> 405
<212> PRT
<213> Homo sapiens

<400> 5442
Met Pro Leu Leu Leu Tyr Thr Cys Leu Leu Trp Leu Pro Thr Ser Gly
 1               5                  10                  15      
Leu Trp Thr Val Gln Ala Met Asp Pro Asn Ala Ala Tyr Val Asn Met
            20                  25                  30          
Ser Asn His His Arg Gly Leu Ala Ser Ala Asn Val Asp Phe Ala Phe
        35                  40                  45              
Ser Leu Tyr Lys His Leu Val Ala Leu Ser Pro Lys Lys Asn Ile Phe
    50                  55                  60                  
Ile Ser Pro Val Ser Ile Ser Met Ala Leu Ala Met Leu Ser Leu Gly
65                  70                  75                  80  
Thr Cys Gly His Thr Arg Ala Gln Leu Leu Gln Gly Leu Gly Phe Asn
                85                  90                  95      
Leu Thr Glu Arg Ser Glu Thr Glu Ile His Gln Gly Phe Gln His Leu
            100                 105                 110         
His Gln Leu Phe Ala Lys Ser Asp Thr Ser Leu Glu Met Thr Met Gly
        115                 120                 125             
Asn Ala Leu Phe Leu Asp Gly Ser Leu Glu Leu Leu Glu Ser Phe Ser
    130                 135                 140                 
Ala Asp Ile Lys His Tyr Tyr Glu Ser Glu Val Leu Ala Met Asn Phe
145                 150                 155                 160 
Gln Asp Trp Ala Thr Ala Ser Arg Gln Ile Asn Ser Tyr Val Lys Asn
                165                 170                 175     
Lys Thr Gln Gly Lys Ile Val Asp Leu Phe Ser Gly Leu Asp Ser Pro
            180                 185                 190         
Ala Ile Leu Val Leu Val Asn Tyr Ile Phe Phe Lys Gly Thr Trp Thr
        195                 200                 205             
Gln Pro Phe Asp Leu Ala Ser Thr Arg Glu Glu Asn Phe Tyr Val Asp
    210                 215                 220                 
Glu Thr Thr Val Val Lys Val Pro Met Met Leu Gln Ser Ser Thr Ile
225                 230                 235                 240 
Ser Tyr Leu His Asp Ser Glu Leu Pro Cys Gln Leu Val Gln Met Asn
                245                 250                 255     
Tyr Val Gly Asn Gly Thr Val Phe Phe Ile Leu Pro Asp Lys Gly Lys
            260                 265                 270         
Met Asn Thr Val Ile Ala Ala Leu Ser Arg Asp Thr Ile Asn Arg Trp
        275                 280                 285             
Ser Ala Gly Leu Thr Ser Ser Gln Val Asp Leu Tyr Ile Pro Lys Val
    290                 295                 300                 
Thr Ile Ser Gly Val Tyr Asp Leu Gly Asp Val Leu Glu Glu Met Gly
305                 310                 315                 320 
Ile Ala Asp Leu Phe Thr Asn Gln Ala Asn Phe Ser Arg Ile Thr Gln
                325                 330                 335     
Asp Ala Gln Leu Lys Ser Ser Lys Val Val His Lys Ala Val Leu Gln
            340                 345                 350         
Leu Asn Glu Glu Gly Val Asp Thr Ala Gly Ser Thr Gly Val Thr Leu
        355                 360                 365             
Asn Leu Thr Ser Lys Pro Ile Ile Leu Arg Phe Asn Gln Pro Phe Ile
    370                 375                 380                 
Ile Met Ile Phe Asp His Phe Thr Trp Ser Ser Leu Phe Leu Ala Arg
385                 390                 395                 400 
Val Met Asn Pro Val
                405 


<210> 5443
<211> 327
<212> PRT
<213> Homo sapiens

<400> 5443
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 5444
<211> 418
<212> PRT
<213> Homo sapiens

<400> 5444
Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His
 1               5                  10                  15      
Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp
            20                  25                  30          
Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys
        35                  40                  45              
Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp
    50                  55                  60                  
Leu Tyr Arg Val Arg Ser Ser Met Ser Pro Thr Thr Asn Val Leu Leu
65                  70                  75                  80  
Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala
                85                  90                  95      
Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu
            100                 105                 110         
Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr
        115                 120                 125             
Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe
    130                 135                 140                 
Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys
145                 150                 155                 160 
Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp
                165                 170                 175     
Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu
            180                 185                 190         
Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu
        195                 200                 205             
Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg
    210                 215                 220                 
Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg
225                 230                 235                 240 
Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp
                245                 250                 255     
Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met
            260                 265                 270         
Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu
        275                 280                 285             
Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu
    290                 295                 300                 
Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser
305                 310                 315                 320 
Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser
                325                 330                 335     
Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys
            340                 345                 350         
Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly
        355                 360                 365             
Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe
    370                 375                 380                 
Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp
385                 390                 395                 400 
Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg
                405                 410                 415     
Gly Pro
        


<210> 5445
<211> 543
<212> PRT
<213> Homo sapiens

<400> 5445
Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe
 1               5                  10                  15      
Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu
            20                  25                  30          
Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser
        35                  40                  45              
Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu
    50                  55                  60                  
His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln
65                  70                  75                  80  
Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln
                85                  90                  95      
Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu
            100                 105                 110         
Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe
        115                 120                 125             
Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu
    130                 135                 140                 
Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys
145                 150                 155                 160 
Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys
                165                 170                 175     
Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr
            180                 185                 190         
Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp
        195                 200                 205             
Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro
    210                 215                 220                 
Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe
225                 230                 235                 240 
Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg
                245                 250                 255     
Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp
            260                 265                 270         
Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe
        275                 280                 285             
Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro
    290                 295                 300                 
Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe
305                 310                 315                 320 
Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln
                325                 330                 335     
Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly
            340                 345                 350         
Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp
        355                 360                 365             
Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr
    370                 375                 380                 
Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr
385                 390                 395                 400 
Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His
                405                 410                 415     
Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr
            420                 425                 430         
Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr
        435                 440                 445             
Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly
    450                 455                 460                 
Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly
465                 470                 475                 480 
Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe
                485                 490                 495     
Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu
            500                 505                 510         
Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser
        515                 520                 525             
Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp
    530                 535                 540             


<210> 5446
<211> 485
<212> PRT
<213> Homo sapiens

<400> 5446
Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser
 1               5                  10                  15      
Leu Arg Ala Thr Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala
            20                  25                  30          
Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu
        35                  40                  45              
Ser Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp
    50                  55                  60                  
Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp
65                  70                  75                  80  
Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp
                85                  90                  95      
Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe
            100                 105                 110         
Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val
        115                 120                 125             
His Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala
    130                 135                 140                 
Ser Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala
145                 150                 155                 160 
Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp
                165                 170                 175     
Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val
            180                 185                 190         
Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val
        195                 200                 205             
Val Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val
    210                 215                 220                 
Gln Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp
225                 230                 235                 240 
Phe Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln
                245                 250                 255     
Ala Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val
            260                 265                 270         
Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met
        275                 280                 285             
Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn
    290                 295                 300                 
Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln
305                 310                 315                 320 
His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Pro Phe
                325                 330                 335     
Thr Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp
            340                 345                 350         
Leu Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp
        355                 360                 365             
Met Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu
    370                 375                 380                 
Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu
385                 390                 395                 400 
Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn
                405                 410                 415     
Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu
            420                 425                 430         
Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys
        435                 440                 445             
Pro Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val
    450                 455                 460                 
Tyr Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn
465                 470                 475                 480 
Pro Leu Ser Thr Ala
                485 


<210> 5447
<211> 352
<212> PRT
<213> Homo sapiens

<400> 5447
Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala
 1               5                  10                  15      
Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln
            20                  25                  30          
Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala
        35                  40                  45              
Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr
    50                  55                  60                  
Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser
65                  70                  75                  80  
Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly
                85                  90                  95      
Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser
            100                 105                 110         
Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp
        115                 120                 125             
Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro
    130                 135                 140                 
Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr
145                 150                 155                 160 
Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu
                165                 170                 175     
Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu
            180                 185                 190         
Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu
        195                 200                 205             
Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val
    210                 215                 220                 
Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys
225                 230                 235                 240 
Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys
                245                 250                 255     
Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val
            260                 265                 270         
Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn
        275                 280                 285             
Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala
    290                 295                 300                 
Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys
305                 310                 315                 320 
Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr
                325                 330                 335     
Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn
            340                 345                 350         


<210> 5448
<211> 576
<212> PRT
<213> Homo sapiens

<400> 5448
Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser
 1               5                  10                  15      
Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln
            20                  25                  30          
Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His
        35                  40                  45              
Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn
    50                  55                  60                  
Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu
65                  70                  75                  80  
Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu
                85                  90                  95      
Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu
            100                 105                 110         
Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu
        115                 120                 125             
Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser
    130                 135                 140                 
Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala
145                 150                 155                 160 
Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly
                165                 170                 175     
Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala
            180                 185                 190         
Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala
        195                 200                 205             
Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala
    210                 215                 220                 
Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His
225                 230                 235                 240 
Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg
                245                 250                 255     
Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe
            260                 265                 270         
Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg
        275                 280                 285             
Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr
    290                 295                 300                 
Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg
305                 310                 315                 320 
Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val
                325                 330                 335     
Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln
            340                 345                 350         
Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala
        355                 360                 365             
Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro
    370                 375                 380                 
Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu
385                 390                 395                 400 
Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala
                405                 410                 415     
Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met
            420                 425                 430         
Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser
        435                 440                 445             
Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His
    450                 455                 460                 
Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val
465                 470                 475                 480 
Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu
                485                 490                 495     
Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu
            500                 505                 510         
Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr
        515                 520                 525             
Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His
    530                 535                 540                 
Phe Thr Ala Thr Val Lys Pro Arg Pro Ala Arg Ser Val Ser Lys Arg
545                 550                 555                 560 
Ser Arg Arg Glu Pro Pro Pro Arg Thr Leu Pro Ala Thr Asp Leu Gln
                565                 570                 575     


<210> 5449
<211> 634
<212> PRT
<213> Homo sapiens

<400> 5449
Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser
 1               5                  10                  15      
Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln
            20                  25                  30          
Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His
        35                  40                  45              
Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn
    50                  55                  60                  
Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu
65                  70                  75                  80  
Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu
                85                  90                  95      
Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu
            100                 105                 110         
Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu
        115                 120                 125             
Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser
    130                 135                 140                 
Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala
145                 150                 155                 160 
Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly
                165                 170                 175     
Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala
            180                 185                 190         
Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala
        195                 200                 205             
Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala
    210                 215                 220                 
Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His
225                 230                 235                 240 
Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg
                245                 250                 255     
Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe
            260                 265                 270         
Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg
        275                 280                 285             
Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr
    290                 295                 300                 
Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg
305                 310                 315                 320 
Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val
                325                 330                 335     
Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln
            340                 345                 350         
Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala
        355                 360                 365             
Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro
    370                 375                 380                 
Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu
385                 390                 395                 400 
Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala
                405                 410                 415     
Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met
            420                 425                 430         
Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser
        435                 440                 445             
Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His
    450                 455                 460                 
Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val
465                 470                 475                 480 
Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu
                485                 490                 495     
Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu
            500                 505                 510         
Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr
        515                 520                 525             
Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His
    530                 535                 540                 
Phe Thr Ala Val Ser Leu Arg Ser Leu His Tyr Thr Ala Arg Arg Pro
545                 550                 555                 560 
Ser Val Tyr Thr Ser Ser Thr Arg Pro Leu Pro Pro Ala Cys Asn Ser
                565                 570                 575     
Cys Ala Arg Thr Ala Ser Ala Arg Pro Pro Thr Ser Arg Arg His Val
            580                 585                 590         
Tyr Ser Gly Asn Leu Gly Pro Ala Phe Ala Gly His Ser Ala Gly Asn
        595                 600                 605             
Ile Pro Asp Pro Val Thr Ser Ala Tyr Ala Ala Ser Ala Gln Pro Gln
    610                 615                 620                 
Thr Gln Pro Ala Cys Pro Phe Pro Ser Ser
625                 630                 


<210> 5450
<211> 599
<212> PRT
<213> Homo sapiens

<400> 5450
Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu
 1               5                  10                  15      
Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe
            20                  25                  30          
Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile
        35                  40                  45              
Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu
    50                  55                  60                  
Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp
65                  70                  75                  80  
Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu
                85                  90                  95      
Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His
            100                 105                 110         
Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn
        115                 120                 125             
Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro
    130                 135                 140                 
Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn
145                 150                 155                 160 
His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro
                165                 170                 175     
Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys
            180                 185                 190         
Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro
        195                 200                 205             
Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys
    210                 215                 220                 
Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile
225                 230                 235                 240 
Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile
                245                 250                 255     
Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly
            260                 265                 270         
Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile
        275                 280                 285             
Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu
    290                 295                 300                 
Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp
305                 310                 315                 320 
Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser
                325                 330                 335     
Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala
            340                 345                 350         
Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro
        355                 360                 365             
Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys
    370                 375                 380                 
Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys
385                 390                 395                 400 
Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys
                405                 410                 415     
Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu
            420                 425                 430         
Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val
        435                 440                 445             
Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu
    450                 455                 460                 
Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly
465                 470                 475                 480 
Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp
                485                 490                 495     
His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser
            500                 505                 510         
Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu
        515                 520                 525             
Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln
    530                 535                 540                 
Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu
545                 550                 555                 560 
Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val
                565                 570                 575     
Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu
            580                 585                 590         
Glu Ser Pro Lys Ile Gly Asn
        595                 


<210> 5451
<211> 4563
<212> PRT
<213> Homo sapiens

<400> 5451
Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu
            20                  25                  30          
Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His
        35                  40                  45              
Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val
    50                  55                  60                  
Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val
65                  70                  75                  80  
Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln
                85                  90                  95      
Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu
            100                 105                 110         
Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg
        115                 120                 125             
Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr
    130                 135                 140                 
Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile
145                 150                 155                 160 
Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val
                165                 170                 175     
Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val
            180                 185                 190         
Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp
        195                 200                 205             
Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro
    210                 215                 220                 
Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser
225                 230                 235                 240 
Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val
                245                 250                 255     
Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr
            260                 265                 270         
Asn Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu
        275                 280                 285             
Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys
    290                 295                 300                 
Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys
305                 310                 315                 320 
Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr
                325                 330                 335     
Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val
            340                 345                 350         
Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro
        355                 360                 365             
Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln
    370                 375                 380                 
Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg
385                 390                 395                 400 
Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala
                405                 410                 415     
Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met
            420                 425                 430         
Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala
        435                 440                 445             
Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu
    450                 455                 460                 
Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly
465                 470                 475                 480 
Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly
                485                 490                 495     
Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys
            500                 505                 510         
Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile
        515                 520                 525             
Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu
    530                 535                 540                 
Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala
545                 550                 555                 560 
Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys
                565                 570                 575     
Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe
            580                 585                 590         
Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile
        595                 600                 605             
Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu
    610                 615                 620                 
Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr
625                 630                 635                 640 
Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu
                645                 650                 655     
Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met
            660                 665                 670         
Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile
        675                 680                 685             
Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu
    690                 695                 700                 
Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr
705                 710                 715                 720 
Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp
                725                 730                 735     
His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn
            740                 745                 750         
Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys
        755                 760                 765             
Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu
    770                 775                 780                 
Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu
785                 790                 795                 800 
Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val
                805                 810                 815     
Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met
            820                 825                 830         
Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile
        835                 840                 845             
Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu
    850                 855                 860                 
Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser
865                 870                 875                 880 
Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg
                885                 890                 895     
Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu
            900                 905                 910         
Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser
        915                 920                 925             
Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu
    930                 935                 940                 
Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg
945                 950                 955                 960 
Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys
                965                 970                 975     
Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr
            980                 985                 990         
Tyr Pro Leu Thr Gly Asp Thr Arg Leu Glu Leu Glu Leu Arg Pro Thr
        995                 1000                1005            
Gly Glu Ile Glu Gln Tyr Ser Val Ser Ala Thr Tyr Glu Leu Gln Arg
    1010                1015                1020                
Glu Asp Arg Ala Leu Val Asp Thr Leu Lys Phe Val Thr Gln Ala Glu
1025                1030                1035                1040
Gly Ala Lys Gln Thr Glu Ala Thr Met Thr Phe Lys Tyr Asn Arg Gln
                1045                1050                1055    
Ser Met Thr Leu Ser Ser Glu Val Gln Ile Pro Asp Phe Asp Val Asp
            1060                1065                1070        
Leu Gly Thr Ile Leu Arg Val Asn Asp Glu Ser Thr Glu Gly Lys Thr
        1075                1080                1085            
Ser Tyr Arg Leu Thr Leu Asp Ile Gln Asn Lys Lys Ile Thr Glu Val
    1090                1095                1100                
Ala Leu Met Gly His Leu Ser Cys Asp Thr Lys Glu Glu Arg Lys Ile
1105                1110                1115                1120
Lys Gly Val Ile Ser Ile Pro Arg Leu Gln Ala Glu Ala Arg Ser Glu
                1125                1130                1135    
Ile Leu Ala His Trp Ser Pro Ala Lys Leu Leu Leu Gln Met Asp Ser
            1140                1145                1150        
Ser Ala Thr Ala Tyr Gly Ser Thr Val Ser Lys Arg Val Ala Trp His
        1155                1160                1165            
Tyr Asp Glu Glu Lys Ile Glu Phe Glu Trp Asn Thr Gly Thr Asn Val
    1170                1175                1180                
Asp Thr Lys Lys Met Thr Ser Asn Phe Pro Val Asp Leu Ser Asp Tyr
1185                1190                1195                1200
Pro Lys Ser Leu His Met Tyr Ala Asn Arg Leu Leu Asp His Arg Val
                1205                1210                1215    
Pro Glu Thr Asp Met Thr Phe Arg His Val Gly Ser Lys Leu Ile Val
            1220                1225                1230        
Ala Met Ser Ser Trp Leu Gln Lys Ala Ser Gly Ser Leu Pro Tyr Thr
        1235                1240                1245            
Gln Thr Leu Gln Asp His Leu Asn Ser Leu Lys Glu Phe Asn Leu Gln
    1250                1255                1260                
Asn Met Gly Leu Pro Asp Phe His Ile Pro Glu Asn Leu Phe Leu Lys
1265                1270                1275                1280
Ser Asp Gly Arg Val Lys Tyr Thr Leu Asn Lys Asn Ser Leu Lys Ile
                1285                1290                1295    
Glu Ile Pro Leu Pro Phe Gly Gly Lys Ser Ser Arg Asp Leu Lys Met
            1300                1305                1310        
Leu Glu Thr Val Arg Thr Pro Ala Leu His Phe Lys Ser Val Gly Phe
        1315                1320                1325            
His Leu Pro Ser Arg Glu Phe Gln Val Pro Thr Phe Thr Ile Pro Lys
    1330                1335                1340                
Leu Tyr Gln Leu Gln Val Pro Leu Leu Gly Val Leu Asp Leu Ser Thr
1345                1350                1355                1360
Asn Val Tyr Ser Asn Leu Tyr Asn Trp Ser Ala Ser Tyr Ser Gly Gly
                1365                1370                1375    
Asn Thr Ser Thr Asp His Phe Ser Leu Arg Ala Arg Tyr His Met Lys
            1380                1385                1390        
Ala Asp Ser Val Val Asp Leu Leu Ser Tyr Asn Val Gln Gly Ser Gly
        1395                1400                1405            
Glu Thr Thr Tyr Asp His Lys Asn Thr Phe Thr Leu Ser Cys Asp Gly
    1410                1415                1420                
Ser Leu Arg His Lys Phe Leu Asp Ser Asn Ile Lys Phe Ser His Val
1425                1430                1435                1440
Glu Lys Leu Gly Asn Asn Pro Val Ser Lys Gly Leu Leu Ile Phe Asp
                1445                1450                1455    
Ala Ser Ser Ser Trp Gly Pro Gln Met Ser Ala Ser Val His Leu Asp
            1460                1465                1470        
Ser Lys Lys Lys Gln His Leu Phe Val Lys Glu Val Lys Ile Asp Gly
        1475                1480                1485            
Gln Phe Arg Val Ser Ser Phe Tyr Ala Lys Gly Thr Tyr Gly Leu Ser
    1490                1495                1500                
Cys Gln Arg Asp Pro Asn Thr Gly Arg Leu Asn Gly Glu Ser Asn Leu
1505                1510                1515                1520
Arg Phe Asn Ser Ser Tyr Leu Gln Gly Thr Asn Gln Ile Thr Gly Arg
                1525                1530                1535    
Tyr Glu Asp Gly Thr Leu Ser Leu Thr Ser Thr Ser Asp Leu Gln Ser
            1540                1545                1550        
Gly Ile Ile Lys Asn Thr Ala Ser Leu Lys Tyr Glu Asn Tyr Glu Leu
        1555                1560                1565            
Thr Leu Lys Ser Asp Thr Asn Gly Lys Tyr Lys Asn Phe Ala Thr Ser
    1570                1575                1580                
Asn Lys Met Asp Met Thr Phe Ser Lys Gln Asn Ala Leu Leu Arg Ser
1585                1590                1595                1600
Glu Tyr Gln Ala Asp Tyr Glu Ser Leu Arg Phe Phe Ser Leu Leu Ser
                1605                1610                1615    
Gly Ser Leu Asn Ser His Gly Leu Glu Leu Asn Ala Asp Ile Leu Gly
            1620                1625                1630        
Thr Asp Lys Ile Asn Ser Gly Ala His Lys Ala Thr Leu Arg Ile Gly
        1635                1640                1645            
Gln Asp Gly Ile Ser Thr Ser Ala Thr Thr Asn Leu Lys Cys Ser Leu
    1650                1655                1660                
Leu Val Leu Glu Asn Glu Leu Asn Ala Glu Leu Gly Leu Ser Gly Ala
1665                1670                1675                1680
Ser Met Lys Leu Thr Thr Asn Gly Arg Phe Arg Glu His Asn Ala Lys
                1685                1690                1695    
Phe Ser Leu Asp Gly Lys Ala Ala Leu Thr Glu Leu Ser Leu Gly Ser
            1700                1705                1710        
Ala Tyr Gln Ala Met Ile Leu Gly Val Asp Ser Lys Asn Ile Phe Asn
        1715                1720                1725            
Phe Lys Val Ser Gln Glu Gly Leu Lys Leu Ser Asn Asp Met Met Gly
    1730                1735                1740                
Ser Tyr Ala Glu Met Lys Phe Asp His Thr Asn Ser Leu Asn Ile Ala
1745                1750                1755                1760
Gly Leu Ser Leu Asp Phe Ser Ser Lys Leu Asp Asn Ile Tyr Ser Ser
                1765                1770                1775    
Asp Lys Phe Tyr Lys Gln Thr Val Asn Leu Gln Leu Gln Pro Tyr Ser
            1780                1785                1790        
Leu Val Thr Thr Leu Asn Ser Asp Leu Lys Tyr Asn Ala Leu Asp Leu
        1795                1800                1805            
Thr Asn Asn Gly Lys Leu Arg Leu Glu Pro Leu Lys Leu His Val Ala
    1810                1815                1820                
Gly Asn Leu Lys Gly Ala Tyr Gln Asn Asn Glu Ile Lys His Ile Tyr
1825                1830                1835                1840
Ala Ile Ser Ser Ala Ala Leu Ser Ala Ser Tyr Lys Ala Asp Thr Val
                1845                1850                1855    
Ala Lys Val Gln Gly Val Glu Phe Ser His Arg Leu Asn Thr Asp Ile
            1860                1865                1870        
Ala Gly Leu Ala Ser Ala Ile Asp Met Ser Thr Asn Tyr Asn Ser Asp
        1875                1880                1885            
Ser Leu His Phe Ser Asn Val Phe Arg Ser Val Met Ala Pro Phe Thr
    1890                1895                1900                
Met Thr Ile Asp Ala His Thr Asn Gly Asn Gly Lys Leu Ala Leu Trp
1905                1910                1915                1920
Gly Glu His Thr Gly Gln Leu Tyr Ser Lys Phe Leu Leu Lys Ala Glu
                1925                1930                1935    
Pro Leu Ala Phe Thr Phe Ser His Asp Tyr Lys Gly Ser Thr Ser His
            1940                1945                1950        
His Leu Val Ser Arg Lys Ser Ile Ser Ala Ala Leu Glu His Lys Val
        1955                1960                1965            
Ser Ala Leu Leu Thr Pro Ala Glu Gln Thr Gly Thr Trp Lys Leu Lys
    1970                1975                1980                
Thr Gln Phe Asn Asn Asn Glu Tyr Ser Gln Asp Leu Asp Ala Tyr Asn
1985                1990                1995                2000
Thr Lys Asp Lys Ile Gly Val Glu Leu Thr Gly Arg Thr Leu Ala Asp
                2005                2010                2015    
Leu Thr Leu Leu Asp Ser Pro Ile Lys Val Pro Leu Leu Leu Ser Glu
            2020                2025                2030        
Pro Ile Asn Ile Ile Asp Ala Leu Glu Met Arg Asp Ala Val Glu Lys
        2035                2040                2045            
Pro Gln Glu Phe Thr Ile Val Ala Phe Val Lys Tyr Asp Lys Asn Gln
    2050                2055                2060                
Asp Val His Ser Ile Asn Leu Pro Phe Phe Glu Thr Leu Gln Glu Tyr
2065                2070                2075                2080
Phe Glu Arg Asn Arg Gln Thr Ile Ile Val Val Val Glu Asn Val Gln
                2085                2090                2095    
Arg Asn Leu Lys His Ile Asn Ile Asp Gln Phe Val Arg Lys Tyr Arg
            2100                2105                2110        
Ala Ala Leu Gly Lys Leu Pro Gln Gln Ala Asn Asp Tyr Leu Asn Ser
        2115                2120                2125            
Phe Asn Trp Glu Arg Gln Val Ser His Ala Lys Glu Lys Leu Thr Ala
    2130                2135                2140                
Leu Thr Lys Lys Tyr Arg Ile Thr Glu Asn Asp Ile Gln Ile Ala Leu
2145                2150                2155                2160
Asp Asp Ala Lys Ile Asn Phe Asn Glu Lys Leu Ser Gln Leu Gln Thr
                2165                2170                2175    
Tyr Met Ile Gln Phe Asp Gln Tyr Ile Lys Asp Ser Tyr Asp Leu His
            2180                2185                2190        
Asp Leu Lys Ile Ala Ile Ala Asn Ile Ile Asp Glu Ile Ile Glu Lys
        2195                2200                2205            
Leu Lys Ser Leu Asp Glu His Tyr His Ile Arg Val Asn Leu Val Lys
    2210                2215                2220                
Thr Ile His Asp Leu His Leu Phe Ile Glu Asn Ile Asp Phe Asn Lys
2225                2230                2235                2240
Ser Gly Ser Ser Thr Ala Ser Trp Ile Gln Asn Val Asp Thr Lys Tyr
                2245                2250                2255    
Gln Ile Arg Ile Gln Ile Gln Glu Lys Leu Gln Gln Leu Lys Arg His
            2260                2265                2270        
Ile Gln Asn Ile Asp Ile Gln His Leu Ala Gly Lys Leu Lys Gln His
        2275                2280                2285            
Ile Glu Ala Ile Asp Val Arg Val Leu Leu Asp Gln Leu Gly Thr Thr
    2290                2295                2300                
Ile Ser Phe Glu Arg Ile Asn Asp Val Leu Glu His Val Lys His Phe
2305                2310                2315                2320
Val Ile Asn Leu Ile Gly Asp Phe Glu Val Ala Glu Lys Ile Asn Ala
                2325                2330                2335    
Phe Arg Ala Lys Val His Glu Leu Ile Glu Arg Tyr Glu Val Asp Gln
            2340                2345                2350        
Gln Ile Gln Val Leu Met Asp Lys Leu Val Glu Leu Thr His Gln Tyr
        2355                2360                2365            
Lys Leu Lys Glu Thr Ile Gln Lys Leu Ser Asn Val Leu Gln Gln Val
    2370                2375                2380                
Lys Ile Lys Asp Tyr Phe Glu Lys Leu Val Gly Phe Ile Asp Asp Ala
2385                2390                2395                2400
Val Lys Lys Leu Asn Glu Leu Ser Phe Lys Thr Phe Ile Glu Asp Val
                2405                2410                2415    
Asn Lys Phe Leu Asp Met Leu Ile Lys Lys Leu Lys Ser Phe Asp Tyr
            2420                2425                2430        
His Gln Phe Val Asp Glu Thr Asn Asp Lys Ile Arg Glu Val Thr Gln
        2435                2440                2445            
Arg Leu Asn Gly Glu Ile Gln Ala Leu Glu Leu Pro Gln Lys Ala Glu
    2450                2455                2460                
Ala Leu Lys Leu Phe Leu Glu Glu Thr Lys Ala Thr Val Ala Val Tyr
2465                2470                2475                2480
Leu Glu Ser Leu Gln Asp Thr Lys Ile Thr Leu Ile Ile Asn Trp Leu
                2485                2490                2495    
Gln Glu Ala Leu Ser Ser Ala Ser Leu Ala His Met Lys Ala Lys Phe
            2500                2505                2510        
Arg Glu Thr Leu Glu Asp Thr Arg Asp Arg Met Tyr Gln Met Asp Ile
        2515                2520                2525            
Gln Gln Glu Leu Gln Arg Tyr Leu Ser Leu Val Gly Gln Val Tyr Ser
    2530                2535                2540                
Thr Leu Val Thr Tyr Ile Ser Asp Trp Trp Thr Leu Ala Ala Lys Asn
2545                2550                2555                2560
Leu Thr Asp Phe Ala Glu Gln Tyr Ser Ile Gln Asp Trp Ala Lys Arg
                2565                2570                2575    
Met Lys Ala Leu Val Glu Gln Gly Phe Thr Val Pro Glu Ile Lys Thr
            2580                2585                2590        
Ile Leu Gly Thr Met Pro Ala Phe Glu Val Ser Leu Gln Ala Leu Gln
        2595                2600                2605            
Lys Ala Thr Phe Gln Thr Pro Asp Phe Ile Val Pro Leu Thr Asp Leu
    2610                2615                2620                
Arg Ile Pro Ser Val Gln Ile Asn Phe Lys Asp Leu Lys Asn Ile Lys
2625                2630                2635                2640
Ile Pro Ser Arg Phe Ser Thr Pro Glu Phe Thr Ile Leu Asn Thr Phe
                2645                2650                2655    
His Ile Pro Ser Phe Thr Ile Asp Phe Val Glu Met Lys Val Lys Ile
            2660                2665                2670        
Ile Arg Thr Ile Asp Gln Met Gln Asn Ser Glu Leu Gln Trp Pro Val
        2675                2680                2685            
Pro Asp Ile Tyr Leu Arg Asp Leu Lys Val Glu Asp Ile Pro Leu Ala
    2690                2695                2700                
Arg Ile Thr Leu Pro Asp Phe Arg Leu Pro Glu Ile Ala Ile Pro Glu
2705                2710                2715                2720
Phe Ile Ile Pro Thr Leu Asn Leu Asn Asp Phe Gln Val Pro Asp Leu
                2725                2730                2735    
His Ile Pro Glu Phe Gln Leu Pro His Ile Ser His Thr Ile Glu Val
            2740                2745                2750        
Pro Thr Phe Gly Lys Leu Tyr Ser Ile Leu Lys Ile Gln Ser Pro Leu
        2755                2760                2765            
Phe Thr Leu Asp Ala Asn Ala Asp Ile Gly Asn Gly Thr Thr Ser Ala
    2770                2775                2780                
Asn Glu Ala Gly Ile Ala Ala Ser Ile Thr Ala Lys Gly Glu Ser Lys
2785                2790                2795                2800
Leu Glu Val Leu Asn Phe Asp Phe Gln Ala Asn Ala Gln Leu Ser Asn
                2805                2810                2815    
Pro Lys Ile Asn Pro Leu Ala Leu Lys Glu Ser Val Lys Phe Ser Ser
            2820                2825                2830        
Lys Tyr Leu Arg Thr Glu His Gly Ser Glu Met Leu Phe Phe Gly Asn
        2835                2840                2845            
Ala Ile Glu Gly Lys Ser Asn Thr Val Ala Ser Leu His Thr Glu Lys
    2850                2855                2860                
Asn Thr Leu Glu Leu Ser Asn Gly Val Ile Val Lys Ile Asn Asn Gln
2865                2870                2875                2880
Leu Thr Leu Asp Ser Asn Thr Lys Tyr Phe His Lys Leu Asn Ile Pro
                2885                2890                2895    
Lys Leu Asp Phe Ser Ser Gln Ala Asp Leu Arg Asn Glu Ile Lys Thr
            2900                2905                2910        
Leu Leu Lys Ala Gly His Ile Ala Trp Thr Ser Ser Gly Lys Gly Ser
        2915                2920                2925            
Trp Lys Trp Ala Cys Pro Arg Phe Ser Asp Glu Gly Thr His Glu Ser
    2930                2935                2940                
Gln Ile Ser Phe Thr Ile Glu Gly Pro Leu Thr Ser Phe Gly Leu Ser
2945                2950                2955                2960
Asn Lys Ile Asn Ser Lys His Leu Arg Val Asn Gln Asn Leu Val Tyr
                2965                2970                2975    
Glu Ser Gly Ser Leu Asn Phe Ser Lys Leu Glu Ile Gln Ser Gln Val
            2980                2985                2990        
Asp Ser Gln His Val Gly His Ser Val Leu Thr Ala Lys Gly Met Ala
        2995                3000                3005            
Leu Phe Gly Glu Gly Lys Ala Glu Phe Thr Gly Arg His Asp Ala His
    3010                3015                3020                
Leu Asn Gly Lys Val Ile Gly Thr Leu Lys Asn Ser Leu Phe Phe Ser
3025                3030                3035                3040
Ala Gln Pro Phe Glu Ile Thr Ala Ser Thr Asn Asn Glu Gly Asn Leu
                3045                3050                3055    
Lys Val Arg Phe Pro Leu Arg Leu Thr Gly Lys Ile Asp Phe Leu Asn
            3060                3065                3070        
Asn Tyr Ala Leu Phe Leu Ser Pro Ser Ala Gln Gln Ala Ser Trp Gln
        3075                3080                3085            
Val Ser Ala Arg Phe Asn Gln Tyr Lys Tyr Asn Gln Asn Phe Ser Ala
    3090                3095                3100                
Gly Asn Asn Glu Asn Ile Met Glu Ala His Val Gly Ile Asn Gly Glu
3105                3110                3115                3120
Ala Asn Leu Asp Phe Leu Asn Ile Pro Leu Thr Ile Pro Glu Met Arg
                3125                3130                3135    
Leu Pro Tyr Thr Ile Ile Thr Thr Pro Pro Leu Lys Asp Phe Ser Leu
            3140                3145                3150        
Trp Glu Lys Thr Gly Leu Lys Glu Phe Leu Lys Thr Thr Lys Gln Ser
        3155                3160                3165            
Phe Asp Leu Ser Val Lys Ala Gln Tyr Lys Lys Asn Lys His Arg His
    3170                3175                3180                
Ser Ile Thr Asn Pro Leu Ala Val Leu Cys Glu Phe Ile Ser Gln Ser
3185                3190                3195                3200
Ile Lys Ser Phe Asp Arg His Phe Glu Lys Asn Arg Asn Asn Ala Leu
                3205                3210                3215    
Asp Phe Val Thr Lys Ser Tyr Asn Glu Thr Lys Ile Lys Phe Asp Lys
            3220                3225                3230        
Tyr Lys Ala Glu Lys Ser His Asp Glu Leu Pro Arg Thr Phe Gln Ile
        3235                3240                3245            
Pro Gly Tyr Thr Val Pro Val Val Asn Val Glu Val Ser Pro Phe Thr
    3250                3255                3260                
Ile Glu Met Ser Ala Phe Gly Tyr Val Phe Pro Lys Ala Val Ser Met
3265                3270                3275                3280
Pro Ser Phe Ser Ile Leu Gly Ser Asp Val Arg Val Pro Ser Tyr Thr
                3285                3290                3295    
Leu Ile Leu Pro Ser Leu Glu Leu Pro Val Leu His Val Pro Arg Asn
            3300                3305                3310        
Leu Lys Leu Ser Leu Pro His Phe Lys Glu Leu Cys Thr Ile Ser His
        3315                3320                3325            
Ile Phe Ile Pro Ala Met Gly Asn Ile Thr Tyr Asp Phe Ser Phe Lys
    3330                3335                3340                
Ser Ser Val Ile Thr Leu Asn Thr Asn Ala Glu Leu Phe Asn Gln Ser
3345                3350                3355                3360
Asp Ile Val Ala His Leu Leu Ser Ser Ser Ser Ser Val Ile Asp Ala
                3365                3370                3375    
Leu Gln Tyr Lys Leu Glu Gly Thr Thr Arg Leu Thr Arg Lys Arg Gly
            3380                3385                3390        
Leu Lys Leu Ala Thr Ala Leu Ser Leu Ser Asn Lys Phe Val Glu Gly
        3395                3400                3405            
Ser His Asn Ser Thr Val Ser Leu Thr Thr Lys Asn Met Glu Val Ser
    3410                3415                3420                
Val Ala Lys Thr Thr Lys Ala Glu Ile Pro Ile Leu Arg Met Asn Phe
3425                3430                3435                3440
Lys Gln Glu Leu Asn Gly Asn Thr Lys Ser Lys Pro Thr Val Ser Ser
                3445                3450                3455    
Ser Met Glu Phe Lys Tyr Asp Phe Asn Ser Ser Met Leu Tyr Ser Thr
            3460                3465                3470        
Ala Lys Gly Ala Val Asp His Lys Leu Ser Leu Glu Ser Leu Thr Ser
        3475                3480                3485            
Tyr Phe Ser Ile Glu Ser Ser Thr Lys Gly Asp Val Lys Gly Ser Val
    3490                3495                3500                
Leu Ser Arg Glu Tyr Ser Gly Thr Ile Ala Ser Glu Ala Asn Thr Tyr
3505                3510                3515                3520
Leu Asn Ser Lys Ser Thr Arg Ser Ser Val Lys Leu Gln Gly Thr Ser
                3525                3530                3535    
Lys Ile Asp Asp Ile Trp Asn Leu Glu Val Lys Glu Asn Phe Ala Gly
            3540                3545                3550        
Glu Ala Thr Leu Gln Arg Ile Tyr Ser Leu Trp Glu His Ser Thr Lys
        3555                3560                3565            
Asn His Leu Gln Leu Glu Gly Leu Phe Phe Thr Asn Gly Glu His Thr
    3570                3575                3580                
Ser Lys Ala Thr Leu Glu Leu Ser Pro Trp Gln Met Ser Ala Leu Val
3585                3590                3595                3600
Gln Val His Ala Ser Gln Pro Ser Ser Phe His Asp Phe Pro Asp Leu
                3605                3610                3615    
Gly Gln Glu Val Ala Leu Asn Ala Asn Thr Lys Asn Gln Lys Ile Arg
            3620                3625                3630        
Trp Lys Asn Glu Val Arg Ile His Ser Gly Ser Phe Gln Ser Gln Val
        3635                3640                3645            
Glu Leu Ser Asn Asp Gln Glu Lys Ala His Leu Asp Ile Ala Gly Ser
    3650                3655                3660                
Leu Glu Gly His Leu Arg Phe Leu Lys Asn Ile Ile Leu Pro Val Tyr
3665                3670                3675                3680
Asp Lys Ser Leu Trp Asp Phe Leu Lys Leu Asp Val Thr Thr Ser Ile
                3685                3690                3695    
Gly Arg Arg Gln His Leu Arg Val Ser Thr Ala Phe Val Tyr Thr Lys
            3700                3705                3710        
Asn Pro Asn Gly Tyr Ser Phe Ser Ile Pro Val Lys Val Leu Ala Asp
        3715                3720                3725            
Lys Phe Ile Thr Pro Gly Leu Lys Leu Asn Asp Leu Asn Ser Val Leu
    3730                3735                3740                
Val Met Pro Thr Phe His Val Pro Phe Thr Asp Leu Gln Val Pro Ser
3745                3750                3755                3760
Cys Lys Leu Asp Phe Arg Glu Ile Gln Ile Tyr Lys Lys Leu Arg Thr
                3765                3770                3775    
Ser Ser Phe Ala Leu Asn Leu Pro Thr Leu Pro Glu Val Lys Phe Pro
            3780                3785                3790        
Glu Val Asp Val Leu Thr Lys Tyr Ser Gln Pro Glu Asp Ser Leu Ile
        3795                3800                3805            
Pro Phe Phe Glu Ile Thr Val Pro Glu Ser Gln Leu Thr Val Ser Gln
    3810                3815                3820                
Phe Thr Leu Pro Lys Ser Val Ser Asp Gly Ile Ala Ala Leu Asp Leu
3825                3830                3835                3840
Asn Ala Val Ala Asn Lys Ile Ala Asp Phe Glu Leu Pro Thr Ile Ile
                3845                3850                3855    
Val Pro Glu Gln Thr Ile Glu Ile Pro Ser Ile Lys Phe Ser Val Pro
            3860                3865                3870        
Ala Gly Ile Val Ile Pro Ser Phe Gln Ala Leu Thr Ala Arg Phe Glu
        3875                3880                3885            
Val Asp Ser Pro Val Tyr Asn Ala Thr Trp Ser Ala Ser Leu Lys Asn
    3890                3895                3900                
Lys Ala Asp Tyr Val Glu Thr Val Leu Asp Ser Thr Cys Ser Ser Thr
3905                3910                3915                3920
Val Gln Phe Leu Glu Tyr Glu Leu Asn Val Leu Gly Thr His Lys Ile
                3925                3930                3935    
Glu Asp Gly Thr Leu Ala Ser Lys Thr Lys Gly Thr Leu Ala His Arg
            3940                3945                3950        
Asp Phe Ser Ala Glu Tyr Glu Glu Asp Gly Lys Phe Glu Gly Leu Gln
        3955                3960                3965            
Glu Trp Glu Gly Lys Ala His Leu Asn Ile Lys Ser Pro Ala Phe Thr
    3970                3975                3980                
Asp Leu His Leu Arg Tyr Gln Lys Asp Lys Lys Gly Ile Ser Thr Ser
3985                3990                3995                4000
Ala Ala Ser Pro Ala Val Gly Thr Val Gly Met Asp Met Asp Glu Asp
                4005                4010                4015    
Asp Asp Phe Ser Lys Trp Asn Phe Tyr Tyr Ser Pro Gln Ser Ser Pro
            4020                4025                4030        
Asp Lys Lys Leu Thr Ile Phe Lys Thr Glu Leu Arg Val Arg Glu Ser
        4035                4040                4045            
Asp Glu Glu Thr Gln Ile Lys Val Asn Trp Glu Glu Glu Ala Ala Ser
    4050                4055                4060                
Gly Leu Leu Thr Ser Leu Lys Asp Asn Val Pro Lys Ala Thr Gly Val
4065                4070                4075                4080
Leu Tyr Asp Tyr Val Asn Lys Tyr His Trp Glu His Thr Gly Leu Thr
                4085                4090                4095    
Leu Arg Glu Val Ser Ser Lys Leu Arg Arg Asn Leu Gln Asn Asn Ala
            4100                4105                4110        
Glu Trp Val Tyr Gln Gly Ala Ile Arg Gln Ile Asp Asp Ile Asp Val
        4115                4120                4125            
Arg Phe Gln Lys Ala Ala Ser Gly Thr Thr Gly Thr Tyr Gln Glu Trp
    4130                4135                4140                
Lys Asp Lys Ala Gln Asn Leu Tyr Gln Glu Leu Leu Thr Gln Glu Gly
4145                4150                4155                4160
Gln Ala Ser Phe Gln Gly Leu Lys Asp Asn Val Phe Asp Gly Leu Val
                4165                4170                4175    
Arg Val Thr Gln Lys Phe His Met Lys Val Lys His Leu Ile Asp Ser
            4180                4185                4190        
Leu Ile Asp Phe Leu Asn Phe Pro Arg Phe Gln Phe Pro Gly Lys Pro
        4195                4200                4205            
Gly Ile Tyr Thr Arg Glu Glu Leu Cys Thr Met Phe Ile Arg Glu Val
    4210                4215                4220                
Gly Thr Val Leu Ser Gln Val Tyr Ser Lys Val His Asn Gly Ser Glu
4225                4230                4235                4240
Ile Leu Phe Ser Tyr Phe Gln Asp Leu Val Ile Thr Leu Pro Phe Glu
                4245                4250                4255    
Leu Arg Lys His Lys Leu Ile Asp Val Ile Ser Met Tyr Arg Glu Leu
            4260                4265                4270        
Leu Lys Asp Leu Ser Lys Glu Ala Gln Glu Val Phe Lys Ala Ile Gln
        4275                4280                4285            
Ser Leu Lys Thr Thr Glu Val Leu Arg Asn Leu Gln Asp Leu Leu Gln
    4290                4295                4300                
Phe Ile Phe Gln Leu Ile Glu Asp Asn Ile Lys Gln Leu Lys Glu Met
4305                4310                4315                4320
Lys Phe Thr Tyr Leu Ile Asn Tyr Ile Gln Asp Glu Ile Asn Thr Ile
                4325                4330                4335    
Phe Asn Asp Tyr Ile Pro Tyr Val Phe Lys Leu Leu Lys Glu Asn Leu
            4340                4345                4350        
Cys Leu Asn Leu His Lys Phe Asn Glu Phe Ile Gln Asn Glu Leu Gln
        4355                4360                4365            
Glu Ala Ser Gln Glu Leu Gln Gln Ile His Gln Tyr Ile Met Ala Leu
    4370                4375                4380                
Arg Glu Glu Tyr Phe Asp Pro Ser Ile Val Gly Trp Thr Val Lys Tyr
4385                4390                4395                4400
Tyr Glu Leu Glu Glu Lys Ile Val Ser Leu Ile Lys Asn Leu Leu Val
                4405                4410                4415    
Ala Leu Lys Asp Phe His Ser Glu Tyr Ile Val Ser Ala Ser Asn Phe
            4420                4425                4430        
Thr Ser Gln Leu Ser Ser Gln Val Glu Gln Phe Leu His Arg Asn Ile
        4435                4440                4445            
Gln Glu Tyr Leu Ser Ile Leu Thr Asp Pro Asp Gly Lys Gly Lys Glu
    4450                4455                4460                
Lys Ile Ala Glu Leu Ser Ala Thr Ala Gln Glu Ile Ile Lys Ser Gln
4465                4470                4475                4480
Ala Ile Ala Thr Lys Lys Ile Ile Ser Asp Tyr His Gln Gln Phe Arg
                4485                4490                4495    
Tyr Lys Leu Gln Asp Phe Ser Asp Gln Leu Ser Asp Tyr Tyr Glu Lys
            4500                4505                4510        
Phe Ile Ala Glu Ser Lys Arg Leu Ile Asp Leu Ser Ile Gln Asn Tyr
        4515                4520                4525            
His Thr Phe Leu Ile Tyr Ile Thr Glu Leu Leu Lys Lys Leu Gln Ser
    4530                4535                4540                
Thr Thr Val Met Asn Pro Tyr Met Lys Leu Ala Pro Gly Glu Leu Thr
4545                4550                4555                4560
Ile Ile Leu
            


<210> 5452
<211> 642
<212> PRT
<213> Homo sapiens

<400> 5452
Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
 1               5                  10                  15      
Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln
            20                  25                  30          
Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser
        35                  40                  45              
Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln
    50                  55                  60                  
Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly
65                  70                  75                  80  
Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr
                85                  90                  95      
Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr
            100                 105                 110         
Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala
        115                 120                 125             
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly
    130                 135                 140                 
Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr
145                 150                 155                 160 
Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu
                165                 170                 175     
Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly
            180                 185                 190         
Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp
        195                 200                 205             
Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr
    210                 215                 220                 
Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr
225                 230                 235                 240 
Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu
                245                 250                 255     
Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
            260                 265                 270         
His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp
        275                 280                 285             
Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro
    290                 295                 300                 
Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met
305                 310                 315                 320 
Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu
                325                 330                 335     
Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly
            340                 345                 350         
Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Asp
        355                 360                 365             
Arg Thr Asp Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser
    370                 375                 380                 
Phe Cys Thr Asp His Thr Val Leu Val Gln Thr Gln Gly Gly Asn Ser
385                 390                 395                 400 
Asn Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr
                405                 410                 415     
Thr Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly
            420                 425                 430         
Thr Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met
        435                 440                 445             
Ala Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg
    450                 455                 460                 
Ile Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg
465                 470                 475                 480 
Cys Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr
                485                 490                 495     
Ser Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val
            500                 505                 510         
Asn Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys
        515                 520                 525             
Thr Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp
    530                 535                 540                 
Gln Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser
545                 550                 555                 560 
Trp Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly
                565                 570                 575     
Arg Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser
            580                 585                 590         
Ser Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro
        595                 600                 605             
Asn Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser
    610                 615                 620                 
Lys Tyr Ile Leu Arg Trp Arg Pro Val Ser Ile Pro Pro Arg Asn Leu
625                 630                 635                 640 
Gly Tyr
        


<210> 5453
<211> 583
<212> PRT
<213> Homo sapiens

<400> 5453
Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg
 1               5                  10                  15      
Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys
            20                  25                  30          
Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys
        35                  40                  45              
Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro
    50                  55                  60                  
Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg
65                  70                  75                  80  
Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro
                85                  90                  95      
Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe
            100                 105                 110         
Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu
        115                 120                 125             
Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser
    130                 135                 140                 
Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln
145                 150                 155                 160 
Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile
                165                 170                 175     
Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser
            180                 185                 190         
Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp
        195                 200                 205             
Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp
    210                 215                 220                 
Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala
225                 230                 235                 240 
Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys
                245                 250                 255     
Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile
            260                 265                 270         
Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu
        275                 280                 285             
Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Ala Gln Glu Glu Thr
    290                 295                 300                 
Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser
305                 310                 315                 320 
Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg
                325                 330                 335     
Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro
            340                 345                 350         
Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile
        355                 360                 365             
Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala
    370                 375                 380                 
Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile
385                 390                 395                 400 
His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile
                405                 410                 415     
Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu
            420                 425                 430         
Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg
        435                 440                 445             
Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn
    450                 455                 460                 
Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg
465                 470                 475                 480 
Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser
                485                 490                 495     
Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly
            500                 505                 510         
Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro
        515                 520                 525             
Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val
    530                 535                 540                 
Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr
545                 550                 555                 560 
Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro
                565                 570                 575     
Phe Ile Ser Gln Tyr Asn Val
            580             


<210> 5454
<211> 377
<212> PRT
<213> Homo sapiens

<400> 5454
Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg
 1               5                  10                  15      
Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys
            20                  25                  30          
Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys
        35                  40                  45              
Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro
    50                  55                  60                  
Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg
65                  70                  75                  80  
Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro
                85                  90                  95      
Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe
            100                 105                 110         
Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu
        115                 120                 125             
Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser
    130                 135                 140                 
Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln
145                 150                 155                 160 
Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile
                165                 170                 175     
Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser
            180                 185                 190         
Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp
        195                 200                 205             
Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp
    210                 215                 220                 
Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala
225                 230                 235                 240 
Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys
                245                 250                 255     
Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile
            260                 265                 270         
Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu
        275                 280                 285             
Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Ala Gln Glu Glu Thr
    290                 295                 300                 
Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser
305                 310                 315                 320 
Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg
                325                 330                 335     
Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Lys Met Lys
            340                 345                 350         
Gln Ile Ser Leu Asp Ile Phe Lys Gly Leu His Arg Val Tyr Ala Ile
        355                 360                 365             
Leu Glu Phe Cys Cys Ile Ile Leu Lys
    370                 375         


<210> 5455
<211> 638
<212> PRT
<213> Homo sapiens

<400> 5455
Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr
 1               5                  10                  15      
Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg
            20                  25                  30          
Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln
        35                  40                  45              
Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro
    50                  55                  60                  
Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys
65                  70                  75                  80  
Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val
                85                  90                  95      
Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His
            100                 105                 110         
Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val
        115                 120                 125             
Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Asn Asn
    130                 135                 140                 
Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala
145                 150                 155                 160 
Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro
                165                 170                 175     
Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys
            180                 185                 190         
Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His
        195                 200                 205             
Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala
    210                 215                 220                 
Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe
225                 230                 235                 240 
Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys
                245                 250                 255     
Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln
            260                 265                 270         
Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu
        275                 280                 285             
Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly
    290                 295                 300                 
Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu
305                 310                 315                 320 
Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu
                325                 330                 335     
Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser
            340                 345                 350         
Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser
        355                 360                 365             
Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr
    370                 375                 380                 
Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly
385                 390                 395                 400 
Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg
                405                 410                 415     
His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala
            420                 425                 430         
Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr
        435                 440                 445             
Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser
    450                 455                 460                 
Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly
465                 470                 475                 480 
Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr
                485                 490                 495     
Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr
            500                 505                 510         
Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys
        515                 520                 525             
Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr
    530                 535                 540                 
Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg
545                 550                 555                 560 
Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly
                565                 570                 575     
Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu
            580                 585                 590         
Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro
        595                 600                 605             
Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys
    610                 615                 620                 
Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala
625                 630                 635             


<210> 5456
<211> 559
<212> PRT
<213> Homo sapiens

<400> 5456
Met Ser Ala Cys Arg Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile
 1               5                  10                  15      
Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu Leu Thr
            20                  25                  30          
Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg Met Ser Pro Trp
        35                  40                  45              
Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu Arg Gln Met Phe Arg Ser
    50                  55                  60                  
Arg Ser Ile Glu Val Phe Gly Gln Phe Asn Gly Lys Arg Cys Thr Asp
65                  70                  75                  80  
Ala Val Gly Asp Arg Arg Gln Cys Val Pro Thr Glu Pro Cys Glu Asp
                85                  90                  95      
Ala Glu Asp Asp Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys
            100                 105                 110         
Ile Lys Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe
        115                 120                 125             
Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp
    130                 135                 140                 
Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly Ile
145                 150                 155                 160 
Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe Asp Asn Glu Phe
                165                 170                 175     
Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp Gly Asn Thr Leu Thr Tyr
            180                 185                 190         
Tyr Arg Arg Pro Trp Asn Val Ala Ser Leu Ile Tyr Glu Thr Lys Gly
        195                 200                 205             
Glu Lys Asn Phe Arg Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe
    210                 215                 220                 
Lys Ser Ile Ile Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser
225                 230                 235                 240 
Leu Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu
                245                 250                 255     
Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe
            260                 265                 270         
Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr Ser Ser
        275                 280                 285             
Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu Ile His Leu Gly
    290                 295                 300                 
Arg Phe Val Met Arg Asn Arg Asp Val Val Leu Thr Thr Thr Phe Val
305                 310                 315                 320 
Asp Asp Ile Lys Ala Leu Pro Thr Thr Tyr Glu Lys Gly Glu Tyr Phe
                325                 330                 335     
Ala Phe Leu Glu Thr Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu
            340                 345                 350         
Gly Gly Leu Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys
        355                 360                 365             
Arg Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His
    370                 375                 380                 
Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe
385                 390                 395                 400 
Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala Val Asn Ile
                405                 410                 415     
Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser Leu Ile Arg Gly Gly
            420                 425                 430         
Thr Arg Lys Tyr Ala Phe Glu Leu Lys Glu Lys Leu Leu Arg Gly Thr
        435                 440                 445             
Val Ile Asp Val Thr Asp Phe Val Asn Trp Ala Ser Ser Ile Asn Asp
    450                 455                 460                 
Ala Pro Val Leu Ile Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val
465                 470                 475                 480 
Pro Val Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg
                485                 490                 495     
Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr
            500                 505                 510         
Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu Cys
        515                 520                 525             
Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile Ser Lys Gln
    530                 535                 540                 
Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe Pro Asn Glu Lys
545                 550                 555                 


<210> 5457
<211> 330
<212> PRT
<213> Homo sapiens

<400> 5457
Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val
 1               5                  10                  15      
Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile
            20                  25                  30          
Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly
        35                  40                  45              
Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys
    50                  55                  60                  
Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr
65                  70                  75                  80  
Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His
                85                  90                  95      
Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile
            100                 105                 110         
Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser
        115                 120                 125             
Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp
    130                 135                 140                 
Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser
145                 150                 155                 160 
Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys
                165                 170                 175     
Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn
            180                 185                 190         
Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys
        195                 200                 205             
Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu
    210                 215                 220                 
Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu
225                 230                 235                 240 
Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp
                245                 250                 255     
Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile
            260                 265                 270         
Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu
        275                 280                 285             
Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr
    290                 295                 300                 
Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly
305                 310                 315                 320 
Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg
                325                 330 


<210> 5458
<211> 330
<212> PRT
<213> Homo sapiens

<400> 5458
Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val
 1               5                  10                  15      
Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile
            20                  25                  30          
Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly
        35                  40                  45              
Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys
    50                  55                  60                  
Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr
65                  70                  75                  80  
Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His
                85                  90                  95      
Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile
            100                 105                 110         
Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser
        115                 120                 125             
Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp
    130                 135                 140                 
Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser
145                 150                 155                 160 
Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys
                165                 170                 175     
Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn
            180                 185                 190         
Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys
        195                 200                 205             
Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu
    210                 215                 220                 
Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu
225                 230                 235                 240 
Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp
                245                 250                 255     
Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile
            260                 265                 270         
Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu
        275                 280                 285             
Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr
    290                 295                 300                 
Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly
305                 310                 315                 320 
Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg
                325                 330 


<210> 5459
<211> 272
<212> PRT
<213> Homo sapiens

<400> 5459
Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala
 1               5                  10                  15      
Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly
            20                  25                  30          
Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala
        35                  40                  45              
Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser
    50                  55                  60                  
Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro
65                  70                  75                  80  
Thr Val Pro Cys Leu Asn Thr Ser Cys Val Asn Pro Pro Thr Val Gln
                85                  90                  95      
Asn Ala His Ile Leu Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu
            100                 105                 110         
Arg Val Arg Tyr Glu Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu
        115                 120                 125             
Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys
    130                 135                 140                 
Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp
145                 150                 155                 160 
Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu
                165                 170                 175     
Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr
            180                 185                 190         
Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys
        195                 200                 205             
Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp
    210                 215                 220                 
Thr Ala Lys Gln Lys Leu Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe
225                 230                 235                 240 
Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg
                245                 250                 255     
Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg
            260                 265                 270         


<210> 5460
<211> 622
<212> PRT
<213> Homo sapiens

<400> 5460
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala
 1               5                  10                  15      
Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln
            20                  25                  30          
Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu
        35                  40                  45              
Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr
    50                  55                  60                  
Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr
65                  70                  75                  80  
Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro
                85                  90                  95      
Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu
            100                 105                 110         
Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu
        115                 120                 125             
Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser
    130                 135                 140                 
Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro
145                 150                 155                 160 
Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val
                165                 170                 175     
Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr
            180                 185                 190         
Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro
        195                 200                 205             
Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg
    210                 215                 220                 
Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala
225                 230                 235                 240 
Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln
                245                 250                 255     
Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val
            260                 265                 270         
Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu
        275                 280                 285             
Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp
    290                 295                 300                 
Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr
305                 310                 315                 320 
Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys
                325                 330                 335     
Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu
            340                 345                 350         
Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser
        355                 360                 365             
Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys
    370                 375                 380                 
Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp
385                 390                 395                 400 
Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn
                405                 410                 415     
Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr
            420                 425                 430         
Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr
        435                 440                 445             
Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala
    450                 455                 460                 
Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro
465                 470                 475                 480 
Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly
                485                 490                 495     
Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr
            500                 505                 510         
Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu
        515                 520                 525             
Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile
    530                 535                 540                 
Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg
545                 550                 555                 560 
Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser
                565                 570                 575     
Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu
            580                 585                 590         
Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg
        595                 600                 605             
Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu
    610                 615                 620         


<210> 5461
<211> 522
<212> PRT
<213> Homo sapiens

<400> 5461
Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
                85                  90                  95      
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Thr Val Arg Gly Arg Gly Gln Arg Leu Cys
        115                 120                 125             
Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser
    130                 135                 140                 
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
145                 150                 155                 160 
Arg Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
                165                 170                 175     
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
            180                 185                 190         
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
        195                 200                 205             
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
    210                 215                 220                 
Thr Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
225                 230                 235                 240 
Lys Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys
                245                 250                 255     
Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro
            260                 265                 270         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg
        275                 280                 285             
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys
    290                 295                 300                 
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
305                 310                 315                 320 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
                325                 330                 335     
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp
            340                 345                 350         
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
        355                 360                 365             
Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu
    370                 375                 380                 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
385                 390                 395                 400 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly
                405                 410                 415     
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
            420                 425                 430         
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
        435                 440                 445             
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn
    450                 455                 460                 
Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe
465                 470                 475                 480 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
                485                 490                 495     
Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr
            500                 505                 510         
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        515                 520         


<210> 5462
<211> 381
<212> PRT
<213> Homo sapiens

<400> 5462
Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser
 1               5                  10                  15      
Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro
            20                  25                  30          
Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser
        35                  40                  45              
Val Thr Val Val Ala Leu Leu Gln Ala Ser Cys Tyr Leu Cys Ile Ile
    50                  55                  60                  
Glu Ala Ser Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly
65                  70                  75                  80  
Tyr Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser
                85                  90                  95      
Arg Leu Lys Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro
            100                 105                 110         
Val Tyr Gln Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn
        115                 120                 125             
Gly Ser Lys Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val
    130                 135                 140                 
Tyr His Leu Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu
145                 150                 155                 160 
Glu Ala Ile Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser
                165                 170                 175     
Leu Thr Thr Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala
            180                 185                 190         
Thr Val Asp Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu
        195                 200                 205             
His His His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser
    210                 215                 220                 
Glu Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro
225                 230                 235                 240 
Pro Gly Leu His His His His Lys His Lys Gly Gln His Arg Gln Gly
                245                 250                 255     
His Pro Glu Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu
            260                 265                 270         
Gln Lys Lys Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys
        275                 280                 285             
Leu Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Cys Cys Cys His Cys
    290                 295                 300                 
Arg His Leu Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Cys Gln Cys
305                 310                 315                 320 
Lys Glu Asn Leu Pro Ser Leu Cys Ser Cys Gln Gly Leu Arg Ala Glu
                325                 330                 335     
Glu Asn Ile Thr Glu Ser Cys Gln Cys Arg Leu Pro Pro Ala Ala Cys
            340                 345                 350         
Gln Ile Ser Gln Gln Leu Ile Pro Thr Glu Ala Ser Ala Ser Cys Arg
        355                 360                 365             
Cys Lys Asn Gln Ala Lys Lys Cys Glu Cys Pro Ser Asn
    370                 375                 380     


<210> 5463
<211> 557
<212> PRT
<213> Homo sapiens

<400> 5463
Gly Gln Pro Gly Ala Thr Arg Ser Ala Leu Thr Lys Met Leu Pro Gly
 1               5                  10                  15      
Ala Trp Leu Leu Trp Thr Ser Leu Leu Leu Leu Ala Arg Pro Ala Gln
            20                  25                  30          
Pro Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser
        35                  40                  45              
Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys
    50                  55                  60                  
Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala
65                  70                  75                  80  
Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asn Thr Gln
                85                  90                  95      
Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu
            100                 105                 110         
Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile
        115                 120                 125             
Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met
    130                 135                 140                 
Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu
145                 150                 155                 160 
Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu
                165                 170                 175     
Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu
            180                 185                 190         
Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln
        195                 200                 205             
Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val
    210                 215                 220                 
Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn
225                 230                 235                 240 
Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu
                245                 250                 255     
Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile
            260                 265                 270         
Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met
        275                 280                 285             
Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val
    290                 295                 300                 
Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Ala Glu Gly Thr
305                 310                 315                 320 
Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala
                325                 330                 335     
Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val
            340                 345                 350         
Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu
        355                 360                 365             
Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln
    370                 375                 380                 
Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn Tyr Asn Leu Phe
385                 390                 395                 400 
Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp Cys His Leu Ala
                405                 410                 415     
Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg Leu Leu Asn Ile
            420                 425                 430         
Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly Gln Val Val Pro
        435                 440                 445             
Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr Arg Asp His Leu
    450                 455                 460                 
Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly Ser Trp
465                 470                 475                 480 
Asp Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln Cys Thr Tyr Ser
                485                 490                 495     
Asn Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln Ala Gln Cys Arg
            500                 505                 510         
Trp Leu Asn Val Gln Leu Ser Pro Trp Gln Gly Ser Leu Gly Leu Gln
        515                 520                 525             
Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser Cys Gly Ser Leu
    530                 535                 540                 
Arg Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly Pro
545                 550                 555         


<210> 5464
<211> 536
<212> PRT
<213> Homo sapiens

<400> 5464
Gln Pro Met Gly Cys Asp Cys Phe Val Gln Glu Val Phe Cys Ser Asp
 1               5                  10                  15      
Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro Pro Tyr Thr Lys Asn
            20                  25                  30          
Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu Glu Thr Arg Ala Phe
        35                  40                  45              
Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe Leu Asp Thr Gln Leu
    50                  55                  60                  
Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu Pro Arg Leu Glu Asp
65                  70                  75                  80  
Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu Ser Thr Asn Ile Phe
                85                  90                  95      
Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu Asn Phe Asn Met Leu
            100                 105                 110         
Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu Ala Ala Leu Glu Ser
        115                 120                 125             
Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu Pro Arg Arg Leu Phe
    130                 135                 140                 
Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu Ala Gln Asn Leu Leu
145                 150                 155                 160 
Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu Thr Ser Leu Gln Thr
                165                 170                 175     
Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe
            180                 185                 190         
Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu Asp Ser Asn Asn Ile
        195                 200                 205             
Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu Phe Cys Leu Glu Arg
    210                 215                 220                 
Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu Pro Leu Ser Ile Phe
225                 230                 235                 240 
Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu Gln Trp Asn Met Leu
                245                 250                 255     
Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr Pro Cys Leu Val Gly
            260                 265                 270         
Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val Thr Glu Gly Thr Phe
        275                 280                 285             
Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu Ser Tyr Asn Ala Ile
    290                 295                 300                 
Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu Glu Glu Leu Val Lys
305                 310                 315                 320 
Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu His Pro Ala Leu Phe
                325                 330                 335     
Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu Ser Lys Asn Gln Leu
            340                 345                 350         
Thr Thr Leu Pro Glu Ala Ser Ser Thr Pro Thr Thr Thr Cys Ser Thr
        355                 360                 365             
Trp Pro Cys Thr Val Thr Pro Gly Ser Ala Thr Ala Pro Gly Leu Pro
    370                 375                 380                 
Leu Gln Leu Ala Ala Ala Val His Arg Ser Ala Pro Glu His Pro Asp
385                 390                 395                 400 
Leu Leu Arg Cys Pro Ala Tyr Leu Lys Gly Gln Val Val His Ala Leu
                405                 410                 415     
Asn Glu Lys Gln Leu Val Ser Val Thr Arg Asp His Leu Gly Phe Gln
            420                 425                 430         
Val Thr Trp Pro Asp Glu Ser Lys Ala Gly Gly Ser Trp Asp Leu Ala
        435                 440                 445             
Val Gln Glu Arg Ala Ala Arg Ser Gln Cys Thr Tyr Ser Asn Pro Glu
    450                 455                 460                 
Gly Thr Val Val Leu Ala Cys Asp Gln Ala Gln Cys Arg Trp Leu Asn
465                 470                 475                 480 
Val Gln Leu Ser Pro Arg Gln Gly Ser Leu Gly Leu Gln Tyr Asn Ala
                485                 490                 495     
Ser Gln Glu Trp Asp Leu Arg Arg Ala Ala Val Leu Cys Gly Ser Pro
            500                 505                 510         
Cys Leu Ser Arg Leu Gly Gln Gln Gly Pro Ser Ser Ser His Thr Gly
        515                 520                 525             
Ala Gly Glu Gly Gly Leu Trp Gly
    530                 535     


<210> 5465
<211> 597
<212> PRT
<213> Homo sapiens

<400> 5465
Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys
 1               5                  10                  15      
Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile
            20                  25                  30          
Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly
        35                  40                  45              
Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile
    50                  55                  60                  
Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr
65                  70                  75                  80  
Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys
                85                  90                  95      
Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys Arg
            100                 105                 110         
Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys Thr
        115                 120                 125             
Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly Phe
    130                 135                 140                 
Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp Arg Gly
145                 150                 155                 160 
Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys Lys
                165                 170                 175     
Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn Phe
            180                 185                 190         
Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe Ser
        195                 200                 205             
Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu Thr Ile
    210                 215                 220                 
Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile Thr Cys Arg
225                 230                 235                 240 
Lys Pro Asp Val Ser His Gly Glu Met Val Ser Gly Phe Gly Pro Ile
                245                 250                 255     
Tyr Asn Tyr Lys Asp Thr Ile Val Phe Lys Cys Gln Lys Gly Phe Val
            260                 265                 270         
Leu Arg Gly Ser Ser Val Ile His Cys Asp Ala Asp Ser Lys Trp Asn
        275                 280                 285             
Pro Ser Pro Pro Ala Cys Glu Pro Asn Ser Cys Ile Asn Leu Pro Asp
    290                 295                 300                 
Ile Pro His Ala Ser Trp Glu Thr Tyr Pro Arg Pro Thr Lys Glu Asp
305                 310                 315                 320 
Val Tyr Val Val Gly Thr Val Leu Arg Tyr Arg Cys His Pro Gly Tyr
                325                 330                 335     
Lys Pro Thr Thr Asp Glu Pro Thr Thr Val Ile Cys Gln Lys Asn Leu
            340                 345                 350         
Arg Trp Thr Pro Tyr Gln Gly Cys Glu Ala Leu Cys Cys Pro Glu Pro
        355                 360                 365             
Lys Leu Asn Asn Gly Glu Ile Thr Gln His Arg Lys Ser Arg Pro Ala
    370                 375                 380                 
Asn His Cys Val Tyr Phe Tyr Gly Asp Glu Ile Ser Phe Ser Cys His
385                 390                 395                 400 
Glu Thr Ser Arg Phe Ser Ala Ile Cys Gln Gly Asp Gly Thr Trp Ser
                405                 410                 415     
Pro Arg Thr Pro Ser Cys Gly Asp Ile Cys Asn Phe Pro Pro Lys Ile
            420                 425                 430         
Ala His Gly His Tyr Lys Gln Ser Ser Ser Tyr Ser Phe Phe Lys Glu
        435                 440                 445             
Glu Ile Ile Tyr Glu Cys Asp Lys Gly Tyr Ile Leu Val Gly Gln Ala
    450                 455                 460                 
Lys Leu Ser Cys Ser Tyr Ser His Trp Ser Ala Pro Ala Pro Gln Cys
465                 470                 475                 480 
Lys Ala Leu Cys Arg Lys Pro Glu Leu Val Asn Gly Arg Leu Ser Val
                485                 490                 495     
Asp Lys Asp Gln Tyr Val Glu Pro Glu Asn Val Thr Ile Gln Cys Asp
            500                 505                 510         
Ser Gly Tyr Gly Val Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn
        515                 520                 525             
Arg Thr Trp Tyr Pro Glu Val Pro Lys Cys Glu Trp Glu Thr Pro Glu
    530                 535                 540                 
Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro
545                 550                 555                 560 
Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu
                565                 570                 575     
Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr
            580                 585                 590         
Leu Asp Lys Glu Leu
        595         


<210> 5466
<211> 415
<212> PRT
<213> Homo sapiens

<400> 5466
Met Ser Pro Phe Leu Tyr Leu Val Leu Leu Val Leu Gly Leu His Ala
 1               5                  10                  15      
Thr Ile His Cys Ala Ser Pro Glu Gly Lys Val Thr Ala Cys His Ser
            20                  25                  30          
Ser Gln Pro Asn Ala Thr Leu Tyr Lys Met Ser Ser Ile Asn Ala Asp
        35                  40                  45              
Phe Ala Phe Asn Leu Tyr Arg Arg Phe Thr Val Glu Thr Pro Asp Lys
    50                  55                  60                  
Asn Ile Phe Phe Ser Pro Val Ser Ile Ser Ala Ala Leu Val Met Leu
65                  70                  75                  80  
Ser Phe Gly Ala Cys Cys Ser Thr Gln Thr Glu Ile Val Glu Thr Leu
                85                  90                  95      
Gly Phe Asn Leu Thr Asp Thr Pro Met Val Glu Ile Gln His Gly Phe
            100                 105                 110         
Gln His Leu Ile Cys Ser Leu Asn Phe Pro Lys Lys Glu Leu Glu Leu
        115                 120                 125             
Gln Ile Gly Asn Ala Leu Phe Ile Gly Lys His Leu Lys Pro Leu Ala
    130                 135                 140                 
Lys Phe Leu Asn Asp Val Lys Thr Leu Tyr Glu Thr Glu Val Phe Ser
145                 150                 155                 160 
Thr Asp Phe Ser Asn Ile Ser Ala Ala Lys Gln Glu Ile Asn Ser His
                165                 170                 175     
Val Glu Met Gln Thr Lys Gly Lys Val Val Gly Leu Ile Gln Asp Leu
            180                 185                 190         
Lys Pro Asn Thr Ile Met Val Leu Val Asn Tyr Ile His Phe Lys Ala
        195                 200                 205             
Gln Trp Ala Asn Pro Phe Asp Pro Ser Lys Thr Glu Asp Ser Ser Ser
    210                 215                 220                 
Phe Leu Ile Asp Lys Thr Thr Thr Val Gln Val Pro Met Met His Gln
225                 230                 235                 240 
Met Glu Gln Tyr Tyr His Leu Val Asp Met Glu Leu Asn Cys Thr Val
                245                 250                 255     
Leu Gln Met Asp Tyr Ser Lys Asn Ala Leu Ala Leu Phe Val Leu Pro
            260                 265                 270         
Lys Glu Gly Gln Met Glu Ser Val Glu Ala Ala Met Ser Ser Lys Thr
        275                 280                 285             
Leu Lys Lys Trp Asn Arg Leu Leu Gln Lys Gly Trp Val Asp Leu Phe
    290                 295                 300                 
Val Pro Lys Phe Ser Ile Ser Ala Thr Tyr Asp Leu Gly Ala Thr Leu
305                 310                 315                 320 
Leu Lys Met Gly Ile Gln His Ala Tyr Ser Glu Asn Ala Asp Phe Ser
                325                 330                 335     
Gly Leu Thr Glu Asp Asn Gly Leu Lys Leu Ser Asn Ala Ala His Lys
            340                 345                 350         
Ala Val Leu His Ile Gly Glu Lys Gly Thr Glu Ala Ala Ala Val Pro
        355                 360                 365             
Glu Val Glu Leu Ser Asp Gln Pro Glu Asn Thr Phe Leu His Pro Ile
    370                 375                 380                 
Ile Gln Ile Asp Arg Ser Phe Met Leu Leu Ile Leu Glu Arg Ser Thr
385                 390                 395                 400 
Arg Ser Ile Leu Phe Leu Gly Lys Val Val Asn Pro Thr Glu Ala
                405                 410                 415 


<210> 5467
<211> 243
<212> PRT
<213> Homo sapiens

<400> 5467
Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val
 1               5                  10                  15      
Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile
            20                  25                  30          
Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly
        35                  40                  45              
Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys
    50                  55                  60                  
Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr
65                  70                  75                  80  
Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His
                85                  90                  95      
Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile
            100                 105                 110         
Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser
        115                 120                 125             
Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ser
    130                 135                 140                 
Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn
145                 150                 155                 160 
Asn Gln Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys
                165                 170                 175     
Leu Asp Pro Cys Val Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile
            180                 185                 190         
Lys Leu Lys Trp Thr Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp
        195                 200                 205             
Ile Val Glu Phe Val Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His
    210                 215                 220                 
Ser Phe Arg Ala Met Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys
225                 230                 235                 240 
Glu Glu Lys
            


<210> 5468
<211> 270
<212> PRT
<213> Homo sapiens

<400> 5468
Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val
 1               5                  10                  15      
Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile
            20                  25                  30          
Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly
        35                  40                  45              
Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys
    50                  55                  60                  
Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr
65                  70                  75                  80  
Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His
                85                  90                  95      
Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile
            100                 105                 110         
Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser
        115                 120                 125             
Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile
    130                 135                 140                 
Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile
145                 150                 155                 160 
Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr
                165                 170                 175     
Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys
            180                 185                 190         
Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val
        195                 200                 205             
Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr
    210                 215                 220                 
Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val
225                 230                 235                 240 
Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met
                245                 250                 255     
Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys
            260                 265                 270 


<210> 5469
<211> 290
<212> PRT
<213> Homo sapiens

<400> 5469
Gln Met Gln Gly Val Asn Cys Thr Val Ser Ser Glu Leu Lys Thr Pro
 1               5                  10                  15      
Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser
            20                  25                  30          
Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys
        35                  40                  45              
Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp
    50                  55                  60                  
Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly
65                  70                  75                  80  
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                85                  90                  95      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            100                 105                 110         
Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Gln Val His
        115                 120                 125             
Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Phe Asn Ser Thr Phe Arg
    130                 135                 140                 
Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly Lys
145                 150                 155                 160 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                165                 170                 175     
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            180                 185                 190         
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        195                 200                 205             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    210                 215                 220                 
Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met
225                 230                 235                 240 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                245                 250                 255     
Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His
            260                 265                 270         
Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro
        275                 280                 285             
Gly Lys
    290 


<210> 5470
<211> 437
<212> PRT
<213> Homo sapiens

<400> 5470
Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala
 1               5                  10                  15      
Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp
            20                  25                  30          
Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr
        35                  40                  45              
Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys
    50                  55                  60                  
Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr
65                  70                  75                  80  
Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro
                85                  90                  95      
Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser
            100                 105                 110         
Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr
        115                 120                 125             
His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn
    130                 135                 140                 
Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln
145                 150                 155                 160 
Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly
                165                 170                 175     
Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu
            180                 185                 190         
Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys
        195                 200                 205             
Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu
    210                 215                 220                 
Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly
225                 230                 235                 240 
Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn
                245                 250                 255     
Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu
            260                 265                 270         
Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr
        275                 280                 285             
Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr
    290                 295                 300                 
Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp
305                 310                 315                 320 
Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met
                325                 330                 335     
Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys
            340                 345                 350         
Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly
        355                 360                 365             
His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser
    370                 375                 380                 
Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr
385                 390                 395                 400 
Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn
                405                 410                 415     
Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys
            420                 425                 430         
Gln Ala Gly Asp Val
        435         


<210> 5471
<211> 453
<212> PRT
<213> Homo sapiens

<400> 5471
Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala
 1               5                  10                  15      
Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp
            20                  25                  30          
Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr
        35                  40                  45              
Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys
    50                  55                  60                  
Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr
65                  70                  75                  80  
Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro
                85                  90                  95      
Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser
            100                 105                 110         
Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr
        115                 120                 125             
His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn
    130                 135                 140                 
Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln
145                 150                 155                 160 
Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly
                165                 170                 175     
Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu
            180                 185                 190         
Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys
        195                 200                 205             
Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu
    210                 215                 220                 
Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly
225                 230                 235                 240 
Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn
                245                 250                 255     
Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu
            260                 265                 270         
Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr
        275                 280                 285             
Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr
    290                 295                 300                 
Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp
305                 310                 315                 320 
Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met
                325                 330                 335     
Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys
            340                 345                 350         
Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly
        355                 360                 365             
His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser
    370                 375                 380                 
Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr
385                 390                 395                 400 
Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn
                405                 410                 415     
Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys
            420                 425                 430         
Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr
        435                 440                 445             
Pro Glu Asp Asp Leu
    450             


<210> 5472
<211> 188
<212> PRT
<213> Homo sapiens

<400> 5472
Met Phe His Gln Ile Trp Ala Ala Leu Leu Tyr Phe Tyr Gly Ile Ile
 1               5                  10                  15      
Leu Asn Ser Ile Tyr Gln Cys Pro Glu His Ser Gln Leu Thr Thr Leu
            20                  25                  30          
Gly Val Asp Gly Lys Glu Phe Pro Glu Val His Leu Gly Gln Trp Tyr
        35                  40                  45              
Phe Ile Ala Gly Ala Ala Pro Thr Lys Glu Glu Leu Ala Thr Phe Asp
    50                  55                  60                  
Pro Val Asp Asn Ile Val Phe Asn Met Ala Ala Gly Ser Ala Pro Met
65                  70                  75                  80  
Gln Leu His Leu Arg Ala Thr Ile Arg Met Lys Asp Gly Leu Cys Val
                85                  90                  95      
Pro Arg Lys Trp Ile Tyr His Leu Thr Glu Gly Ser Thr Asp Leu Arg
            100                 105                 110         
Thr Glu Gly Arg Pro Asp Met Lys Thr Glu Leu Phe Ser Ser Ser Cys
        115                 120                 125             
Pro Gly Gly Ile Met Leu Asn Glu Thr Gly Gln Gly Tyr Gln Arg Phe
    130                 135                 140                 
Leu Leu Tyr Asn Arg Ser Pro His Pro Pro Glu Lys Cys Val Glu Glu
145                 150                 155                 160 
Phe Lys Ser Leu Thr Ser Cys Leu Asp Ser Lys Ala Phe Leu Leu Thr
                165                 170                 175     
Pro Arg Asn Gln Glu Ala Cys Glu Leu Ser Asn Asn
            180                 185             


<210> 5473
<211> 223
<212> PRT
<213> Homo sapiens

<400> 5473
Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu
 1               5                  10                  15      
Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg
            20                  25                  30          
Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro
        35                  40                  45              
Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg
    50                  55                  60                  
Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu
65                  70                  75                  80  
Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg
                85                  90                  95      
His Lys Val Thr Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His
            100                 105                 110         
Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile
        115                 120                 125             
Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val
    130                 135                 140                 
Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly
145                 150                 155                 160 
Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu
                165                 170                 175     
Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr
            180                 185                 190         
Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn
        195                 200                 205             
Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val
    210                 215                 220             


<210> 5474
<211> 840
<212> PRT
<213> Homo sapiens

<400> 5474
Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser
 1               5                  10                  15      
Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile
            20                  25                  30          
Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn
        35                  40                  45              
Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile
    50                  55                  60                  
Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe
65                  70                  75                  80  
His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser
                85                  90                  95      
Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr
            100                 105                 110         
Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala
        115                 120                 125             
Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr
    130                 135                 140                 
Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala
145                 150                 155                 160 
Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe Asn
                165                 170                 175     
Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly Ile
            180                 185                 190         
Tyr Glu Lys Leu Tyr Gly Arg Lys Val Ile Thr Glu Asn Val Ile Val
        195                 200                 205             
Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu Ala
    210                 215                 220                 
Val Ser Lys Leu Tyr Pro Thr Tyr Ser Thr Lys Ser Pro Phe Leu Val
225                 230                 235                 240 
Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala Phe
                245                 250                 255     
Trp Ser Thr Asn Ile Tyr His Leu Thr Ile Phe Met Leu Glu Asn Gly
            260                 265                 270         
Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys Gly
        275                 280                 285             
Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp Phe
    290                 295                 300                 
His Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn Ile
305                 310                 315                 320 
Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr Pro
                325                 330                 335     
Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Ile Arg Thr
            340                 345                 350         
Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Val Ser Ser Pro
        355                 360                 365             
Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp Ala
    370                 375                 380                 
Met Thr Ser Ala Asp Leu Asn Gln Asp Gly His Gly Asp Leu Val Val
385                 390                 395                 400 
Gly Ala Pro Gly Tyr Ser Arg Pro Gly His Ile His Ile Gly Arg Val
                405                 410                 415     
Tyr Leu Ile Tyr Gly Asn Asp Leu Gly Leu Pro Pro Val Asp Leu Asp
            420                 425                 430         
Leu Asp Lys Glu Ala His Arg Ile Leu Glu Gly Phe Gln Pro Ser Gly
        435                 440                 445             
Arg Phe Gly Ser Ala Leu Ala Val Leu Asp Phe Asn Val Asp Gly Val
    450                 455                 460                 
Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu Thr
465                 470                 475                 480 
Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Gly Met
                485                 490                 495     
Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys Asn
            500                 505                 510         
Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu Pro
        515                 520                 525             
Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln Lys
    530                 535                 540                 
Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asp Lys Glu
545                 550                 555                 560 
Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu Asp
                565                 570                 575     
Phe Ser Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn Arg
            580                 585                 590         
Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg Leu
        595                 600                 605             
Gly His Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg Val
    610                 615                 620                 
Tyr Gly Tyr Phe Pro Pro Asn Gly Gln Ser Trp Phe Thr Ile Ser Gly
625                 630                 635                 640 
Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val
                645                 650                 655     
Leu Met Asn Gly Thr Leu Lys Gln Val Leu Leu Val Gly Ala Pro Thr
            660                 665                 670         
Tyr Asp Asp Val Ser Lys Val Ala Phe Leu Thr Val Thr Leu His Gln
        675                 680                 685             
Gly Gly Ala Thr Arg Met Tyr Ala Leu Ile Ser Asp Ala Gln Pro Leu
    690                 695                 700                 
Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly Gly
705                 710                 715                 720 
Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Leu Asp Glu Ile Ile
                725                 730                 735     
Met Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile Gly
            740                 745                 750         
Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr Leu
        755                 760                 765             
Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Ile Thr Pro Cys Pro Glu
    770                 775                 780                 
Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg Phe
785                 790                 795                 800 
Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val Val
                805                 810                 815     
Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala Leu
            820                 825                 830         
His Val Tyr Ser Leu Gly Ser Asp
        835                 840 


<210> 5475
<211> 840
<212> PRT
<213> Homo sapiens

<400> 5475
Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser
 1               5                  10                  15      
Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile
            20                  25                  30          
Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn
        35                  40                  45              
Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile
    50                  55                  60                  
Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe
65                  70                  75                  80  
His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser
                85                  90                  95      
Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr
            100                 105                 110         
Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala
        115                 120                 125             
Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr
    130                 135                 140                 
Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala
145                 150                 155                 160 
Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe Asn
                165                 170                 175     
Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly Ile
            180                 185                 190         
Tyr Glu Lys Leu Tyr Gly Arg Lys Val Ile Thr Glu Asn Val Ile Val
        195                 200                 205             
Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu Ala
    210                 215                 220                 
Val Ser Lys Leu Tyr Pro Thr Tyr Ser Thr Lys Ser Pro Phe Leu Val
225                 230                 235                 240 
Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala Phe
                245                 250                 255     
Trp Ser Thr Asn Ile Tyr His Leu Thr Ser Phe Met Leu Glu Asn Gly
            260                 265                 270         
Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys Gly
        275                 280                 285             
Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp Phe
    290                 295                 300                 
His Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn Ile
305                 310                 315                 320 
Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr Pro
                325                 330                 335     
Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Ile Arg Thr
            340                 345                 350         
Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Val Ser Ser Pro
        355                 360                 365             
Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp Ala
    370                 375                 380                 
Met Thr Ser Ala Asp Leu Asn Gln Asp Gly His Gly Asp Leu Val Val
385                 390                 395                 400 
Gly Ala Pro Gly Tyr Ser Arg Pro Gly His Ile His Ile Gly Arg Val
                405                 410                 415     
Tyr Leu Ile Tyr Gly Asn Asp Leu Gly Leu Pro Pro Val Asp Leu Asp
            420                 425                 430         
Leu Asp Lys Glu Ala His Arg Ile Leu Glu Gly Phe Gln Pro Ser Gly
        435                 440                 445             
Arg Phe Gly Ser Ala Leu Ala Val Leu Asp Phe Asn Val Asp Gly Val
    450                 455                 460                 
Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu Thr
465                 470                 475                 480 
Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Gly Met
                485                 490                 495     
Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys Asn
            500                 505                 510         
Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu Pro
        515                 520                 525             
Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln Lys
    530                 535                 540                 
Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asp Lys Glu
545                 550                 555                 560 
Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu Asp
                565                 570                 575     
Phe Ser Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn Arg
            580                 585                 590         
Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg Leu
        595                 600                 605             
Gly His Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg Val
    610                 615                 620                 
Tyr Gly Tyr Phe Pro Pro Asn Gly Gln Ser Trp Phe Thr Ile Ser Gly
625                 630                 635                 640 
Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val
                645                 650                 655     
Leu Met Asn Gly Thr Leu Lys Gln Val Leu Leu Val Gly Ala Pro Thr
            660                 665                 670         
Tyr Asp Asp Val Ser Lys Val Ala Phe Leu Thr Val Thr Leu His Gln
        675                 680                 685             
Gly Gly Ala Thr Arg Met Tyr Ala Leu Ile Ser Asp Ala Gln Pro Leu
    690                 695                 700                 
Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly Gly
705                 710                 715                 720 
Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Leu Asp Glu Ile Ile
                725                 730                 735     
Met Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile Gly
            740                 745                 750         
Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr Leu
        755                 760                 765             
Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Ile Thr Pro Cys Pro Glu
    770                 775                 780                 
Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg Phe
785                 790                 795                 800 
Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val Val
                805                 810                 815     
Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala Leu
            820                 825                 830         
His Val Tyr Ser Leu Gly Ser Asp
        835                 840 


<210> 5476
<211> 661
<212> PRT
<213> Homo sapiens

<400> 5476
Met Arg Leu Lys Asn Leu Thr Phe Ile Ile Ile Leu Ile Ile Ser Gly
 1               5                  10                  15      
Glu Leu Tyr Ala Glu Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn
            20                  25                  30          
Gly Arg Ile Ala Gln Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro
        35                  40                  45              
Met Ser Ile Asp Lys Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr
    50                  55                  60                  
Thr Glu Ser Gly Arg Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly
65                  70                  75                  80  
Trp Ser Pro Glu Pro Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu
                85                  90                  95      
Ser Asn Gly Tyr Ile Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu
            100                 105                 110         
Asn Met His Tyr Gly Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys
        115                 120                 125             
Asp Glu Glu Val Val Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro
    130                 135                 140                 
Thr Cys Arg Lys Glu His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn
145                 150                 155                 160 
Gly Asn Tyr Ser Thr Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val
                165                 170                 175     
Gln Tyr Glu Cys Ala Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr
            180                 185                 190         
Glu Glu Val Glu Cys Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys
        195                 200                 205             
Thr Lys Leu Lys Cys Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe
    210                 215                 220                 
His Pro Val Lys Gln Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe
225                 230                 235                 240 
Cys His Glu Asn Tyr Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr
                245                 250                 255     
Asn Phe Gly Trp Tyr Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn
            260                 265                 270         
Arg Cys Pro Pro Pro Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His
        275                 280                 285             
Ser Thr Thr Tyr Arg His Gly Glu Ile Val His Ile Glu Cys Glu Leu
    290                 295                 300                 
Asn Phe Glu Ile His Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys
305                 310                 315                 320 
Trp Thr Glu Pro Pro Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys
                325                 330                 335     
Glu Glu Pro Pro Phe Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys
            340                 345                 350         
Ile Tyr Tyr Asn Gly Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr
        355                 360                 365             
Leu Leu His Gly Ser Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr
    370                 375                 380                 
Leu Pro Pro Glu Cys Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro
385                 390                 395                 400 
Val Val Met Asn Gly Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala
                405                 410                 415     
Thr Gly Ser Ser Val Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg
            420                 425                 430         
Gly Ser Lys Ile Ser Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro
        435                 440                 445             
Val Cys Leu Glu Pro Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn
    450                 455                 460                 
Asn Ile Glu Met Lys Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp
465                 470                 475                 480 
Leu Ile Asp Phe Val Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr
                485                 490                 495     
Pro Leu Ser Glu Leu Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr
            500                 505                 510         
Pro Leu Cys Thr Arg Lys Glu Ser Lys Gly Met Cys Thr Ser Pro Pro
        515                 520                 525             
Leu Ile Lys His Gly Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu
    530                 535                 540                 
Asn Gly Ser Ser Val Glu Tyr Arg Cys Phe Asp His His Phe Leu Glu
545                 550                 555                 560 
Gly Ser Arg Glu Ala Tyr Cys Leu Asp Gly Met Trp Thr Thr Pro Pro
                565                 570                 575     
Leu Cys Leu Glu Pro Cys Thr Leu Ser Phe Thr Glu Met Glu Lys Asn
            580                 585                 590         
Asn Leu Leu Leu Lys Trp Asp Phe Asp Asn Arg Pro His Ile Leu His
        595                 600                 605             
Gly Glu Tyr Ile Glu Phe Ile Cys Arg Gly Asp Thr Tyr Pro Ala Glu
    610                 615                 620                 
Leu Tyr Ile Thr Gly Ser Ile Leu Arg Met Gln Cys Asp Arg Gly Gln
625                 630                 635                 640 
Leu Lys Tyr Pro Arg Cys Ile Pro Arg Gln Ser Thr Leu Ser Tyr Gln
                645                 650                 655     
Glu Pro Leu Arg Thr
            660     


<210> 5477
<211> 591
<212> PRT
<213> Homo sapiens

<400> 5477
Met Lys Asn Ser Arg Thr Trp Ala Trp Arg Ala Pro Val Glu Leu Phe
 1               5                  10                  15      
Leu Leu Cys Ala Ala Leu Gly Cys Leu Ser Leu Pro Gly Ser Arg Gly
            20                  25                  30          
Glu Arg Pro His Ser Phe Gly Ser Asn Ala Val Asn Lys Ser Phe Ala
        35                  40                  45              
Lys Ser Arg Gln Met Arg Ser Val Asp Val Thr Leu Met Pro Ile Asp
    50                  55                  60                  
Cys Glu Leu Ser Ser Trp Ser Ser Trp Thr Thr Cys Asp Pro Cys Gln
65                  70                  75                  80  
Lys Lys Arg Tyr Arg Tyr Ala Tyr Leu Leu Gln Pro Ser Gln Phe His
                85                  90                  95      
Gly Glu Pro Cys Asn Phe Ser Asp Lys Glu Val Glu Asp Cys Val Thr
            100                 105                 110         
Asn Arg Pro Cys Arg Ser Gln Val Arg Cys Glu Gly Phe Val Cys Ala
        115                 120                 125             
Gln Thr Gly Arg Cys Val Asn Arg Arg Leu Leu Cys Asn Gly Asp Asn
    130                 135                 140                 
Asp Cys Gly Asp Gln Ser Asp Glu Ala Asn Cys Arg Arg Ile Tyr Lys
145                 150                 155                 160 
Lys Cys Gln His Glu Met Asp Gln Tyr Trp Gly Ile Gly Ser Leu Ala
                165                 170                 175     
Ser Gly Ile Asn Leu Phe Thr Asn Ser Phe Glu Gly Pro Val Leu Asp
            180                 185                 190         
His Arg Tyr Tyr Ala Gly Gly Cys Ser Pro His Tyr Ile Leu Asn Thr
        195                 200                 205             
Arg Phe Arg Lys Pro Tyr Asn Val Glu Ser Tyr Thr Pro Gln Thr Gln
    210                 215                 220                 
Gly Lys Tyr Glu Phe Ile Leu Lys Glu Tyr Glu Ser Tyr Ser Asp Phe
225                 230                 235                 240 
Glu Arg Asn Val Thr Glu Lys Met Ala Ser Lys Ser Gly Phe Ser Phe
                245                 250                 255     
Gly Phe Lys Ile Pro Gly Ile Phe Glu Leu Gly Ile Ser Ser Gln Ser
            260                 265                 270         
Asp Arg Gly Lys His Tyr Ile Arg Arg Thr Lys Arg Phe Ser His Thr
        275                 280                 285             
Lys Ser Val Phe Leu His Ala Arg Ser Asp Leu Glu Val Ala His Tyr
    290                 295                 300                 
Lys Leu Lys Pro Arg Ser Leu Met Leu His Tyr Glu Phe Leu Gln Arg
305                 310                 315                 320 
Val Lys Arg Leu Pro Leu Glu Tyr Ser Tyr Gly Glu Tyr Arg Asp Leu
                325                 330                 335     
Phe Arg Asp Phe Gly Thr His Tyr Ile Thr Glu Ala Val Leu Gly Gly
            340                 345                 350         
Ile Tyr Glu Tyr Thr Leu Val Met Asn Lys Glu Ala Met Glu Arg Gly
        355                 360                 365             
Asp Tyr Thr Leu Asn Asn Val His Ala Cys Ala Lys Asn Asp Phe Lys
    370                 375                 380                 
Ile Gly Gly Ala Ile Glu Glu Val Tyr Val Ser Leu Gly Val Ser Val
385                 390                 395                 400 
Gly Lys Cys Arg Gly Ile Leu Asn Glu Ile Lys Asp Arg Asn Lys Arg
                405                 410                 415     
Asp Thr Met Val Glu Asp Leu Val Val Leu Val Arg Gly Gly Ala Ser
            420                 425                 430         
Glu His Ile Thr Thr Leu Ala Tyr Gln Glu Leu Pro Thr Ala Asp Leu
        435                 440                 445             
Met Gln Glu Trp Gly Asp Ala Val Gln Tyr Asn Pro Ala Ile Ile Lys
    450                 455                 460                 
Val Lys Val Glu Pro Leu Tyr Glu Leu Val Thr Ala Thr Asp Phe Ala
465                 470                 475                 480 
Tyr Ser Ser Thr Val Arg Gln Asn Met Lys Gln Ala Leu Glu Glu Phe
                485                 490                 495     
Gln Lys Glu Val Ser Ser Cys His Cys Ala Pro Cys Gln Gly Asn Gly
            500                 505                 510         
Val Pro Val Leu Lys Gly Ser Arg Cys Asp Cys Ile Cys Pro Val Gly
        515                 520                 525             
Ser Gln Gly Leu Ala Cys Glu Val Ser Tyr Arg Lys Asn Thr Pro Ile
    530                 535                 540                 
Asp Gly Lys Trp Asn Cys Trp Ser Asn Trp Ser Ser Cys Ser Gly Arg
545                 550                 555                 560 
Arg Lys Thr Arg Gln Arg Gln Cys Asn Asn Pro Pro Pro Gln Asn Gly
                565                 570                 575     
Gly Ser Pro Cys Ser Gly Pro Ala Ser Glu Thr Leu Asp Cys Ser
            580                 585                 590     


<210> 5478
<211> 499
<212> PRT
<213> Homo sapiens

<400> 5478
Met Lys His Ser Leu Asn Ala Leu Leu Ile Phe Leu Ile Ile Thr Ser
 1               5                  10                  15      
Ala Trp Gly Gly Ser Lys Gly Pro Leu Asp Gln Leu Glu Lys Gly Gly
            20                  25                  30          
Glu Thr Ala Gln Ser Ala Asp Pro Gln Trp Glu Gln Leu Asn Asn Lys
        35                  40                  45              
Asn Leu Ser Met Pro Leu Leu Pro Ala Asp Phe His Lys Glu Asn Thr
    50                  55                  60                  
Val Thr Asn Asp Trp Ile Pro Glu Gly Glu Glu Asp Asp Asp Tyr Leu
65                  70                  75                  80  
Asp Leu Glu Lys Ile Phe Ser Glu Asp Asp Asp Tyr Ile Asp Ile Val
                85                  90                  95      
Asp Ser Leu Ser Val Ser Pro Thr Asp Ser Asp Val Ser Ala Gly Asn
            100                 105                 110         
Ile Leu Gln Leu Phe His Gly Lys Ser Arg Ile Gln Arg Leu Asn Ile
        115                 120                 125             
Leu Asn Ala Lys Phe Ala Phe Asn Leu Tyr Arg Val Leu Lys Asp Gln
    130                 135                 140                 
Val Asn Thr Phe Asp Asn Ile Phe Ile Ala Pro Val Gly Ile Ser Thr
145                 150                 155                 160 
Ala Met Gly Met Ile Ser Leu Gly Leu Lys Gly Glu Thr His Glu Gln
                165                 170                 175     
Val His Ser Ile Leu His Phe Lys Asp Phe Val Asn Ala Ser Ser Lys
            180                 185                 190         
Tyr Glu Ile Thr Thr Ile His Asn Leu Phe Arg Lys Leu Thr His Arg
        195                 200                 205             
Leu Phe Arg Arg Asn Phe Gly Tyr Thr Leu Arg Ser Val Asn Asp Leu
    210                 215                 220                 
Tyr Ile Gln Lys Gln Phe Pro Ile Leu Leu Asp Phe Lys Thr Lys Val
225                 230                 235                 240 
Arg Glu Tyr Tyr Phe Ala Glu Ala Gln Ile Ala Asp Phe Ser Asp Pro
                245                 250                 255     
Ala Phe Ile Ser Lys Thr Asn Asn His Ile Met Lys Leu Thr Lys Gly
            260                 265                 270         
Leu Ile Lys Asp Ala Leu Glu Asn Ile Asp Pro Ala Thr Gln Met Met
        275                 280                 285             
Ile Leu Asn Cys Ile Tyr Phe Lys Gly Ser Trp Val Asn Lys Phe Pro
    290                 295                 300                 
Val Glu Met Thr His Asn His Asn Phe Arg Leu Asn Glu Arg Glu Val
305                 310                 315                 320 
Val Lys Val Ser Met Met Gln Thr Lys Gly Asn Phe Leu Ala Ala Asn
                325                 330                 335     
Asp Gln Glu Leu Asp Cys Asp Ile Leu Gln Leu Glu Tyr Val Gly Gly
            340                 345                 350         
Ile Ser Met Leu Ile Val Val Pro His Lys Met Ser Gly Met Lys Thr
        355                 360                 365             
Leu Glu Ala Gln Leu Thr Pro Arg Val Val Glu Arg Trp Gln Lys Ser
    370                 375                 380                 
Met Thr Asn Arg Thr Arg Glu Val Leu Leu Pro Lys Phe Lys Leu Glu
385                 390                 395                 400 
Lys Asn Tyr Asn Leu Val Glu Ser Leu Lys Leu Met Gly Ile Arg Met
                405                 410                 415     
Leu Phe Asp Lys Asn Gly Asn Met Ala Gly Ile Ser Asp Gln Arg Ile
            420                 425                 430         
Ala Ile Asp Leu Phe Lys His Gln Gly Thr Ile Thr Val Asn Glu Glu
        435                 440                 445             
Gly Thr Gln Ala Thr Thr Val Thr Thr Val Gly Phe Met Pro Leu Ser
    450                 455                 460                 
Thr Gln Val Arg Phe Thr Val Asp Arg Pro Phe Leu Phe Leu Ile Tyr
465                 470                 475                 480 
Glu His Arg Thr Ser Cys Leu Leu Phe Met Gly Arg Val Ala Asn Pro
                485                 490                 495     
Ser Arg Ser
            


<210> 5479
<211> 584
<212> PRT
<213> Homo sapiens

<400> 5479
Met Phe Ala Val Val Phe Phe Ile Leu Ser Leu Met Thr Cys Gln Pro
 1               5                  10                  15      
Gly Val Thr Ala Gln Glu Lys Val Asn Gln Arg Val Arg Arg Ala Ala
            20                  25                  30          
Thr Pro Ala Ala Val Thr Cys Gln Leu Ser Asn Trp Ser Glu Trp Thr
        35                  40                  45              
Asp Cys Phe Pro Cys Gln Asp Lys Lys Tyr Arg His Arg Ser Leu Leu
    50                  55                  60                  
Gln Pro Asn Lys Phe Gly Gly Thr Ile Cys Ser Gly Asp Ile Trp Asp
65                  70                  75                  80  
Gln Ala Ser Cys Ser Ser Ser Thr Thr Cys Val Arg Gln Ala Gln Cys
                85                  90                  95      
Gly Gln Asp Phe Gln Cys Lys Glu Thr Gly Arg Cys Leu Lys Arg His
            100                 105                 110         
Leu Val Cys Asn Gly Asp Gln Asp Cys Leu Asp Gly Ser Asp Glu Asp
        115                 120                 125             
Asp Cys Glu Asp Val Arg Ala Ile Asp Glu Asp Cys Ser Gln Tyr Glu
    130                 135                 140                 
Pro Ile Pro Gly Ser Gln Lys Ala Ala Leu Gly Tyr Asn Ile Leu Thr
145                 150                 155                 160 
Gln Glu Asp Ala Gln Ser Val Tyr Asp Ala Ser Tyr Tyr Gly Gly Gln
                165                 170                 175     
Cys Glu Thr Val Tyr Asn Gly Glu Trp Arg Glu Leu Arg Tyr Asp Ser
            180                 185                 190         
Thr Cys Glu Arg Leu Tyr Tyr Gly Asp Asp Glu Lys Tyr Phe Arg Lys
        195                 200                 205             
Pro Tyr Asn Phe Leu Lys Tyr His Phe Glu Ala Leu Ala Asp Thr Gly
    210                 215                 220                 
Ile Ser Ser Glu Phe Tyr Asp Asn Ala Asn Asp Leu Leu Ser Lys Val
225                 230                 235                 240 
Lys Lys Asp Lys Ser Asp Ser Phe Gly Val Thr Ile Gly Ile Gly Pro
                245                 250                 255     
Ala Gly Ser Pro Leu Leu Val Gly Val Gly Val Ser His Ser Gln Asp
            260                 265                 270         
Thr Ser Phe Leu Asn Glu Leu Asn Lys Tyr Asn Glu Lys Lys Phe Ile
        275                 280                 285             
Phe Thr Arg Ile Phe Thr Lys Val Gln Thr Ala His Phe Lys Met Arg
    290                 295                 300                 
Lys Asp Asp Ile Met Leu Asp Glu Gly Met Leu Gln Ser Leu Met Glu
305                 310                 315                 320 
Leu Pro Asp Gln Tyr Asn Tyr Gly Met Tyr Ala Lys Phe Ile Asn Asp
                325                 330                 335     
Tyr Gly Thr His Tyr Ile Thr Ser Gly Ser Met Gly Gly Ile Tyr Glu
            340                 345                 350         
Tyr Ile Leu Val Ile Asp Lys Ala Lys Met Glu Ser Leu Gly Ile Thr
        355                 360                 365             
Ser Arg Asp Ile Thr Thr Cys Phe Gly Gly Ser Leu Gly Ile Gln Tyr
    370                 375                 380                 
Glu Asp Lys Ile Asn Val Gly Gly Gly Leu Ser Gly Asp His Cys Lys
385                 390                 395                 400 
Lys Phe Gly Gly Gly Lys Thr Glu Arg Ala Arg Lys Ala Met Ala Val
                405                 410                 415     
Glu Asp Ile Ile Ser Arg Val Arg Gly Gly Ser Ser Gly Trp Ser Gly
            420                 425                 430         
Gly Leu Ala Gln Asn Arg Ser Thr Ile Thr Tyr Arg Ser Trp Gly Arg
        435                 440                 445             
Ser Leu Lys Tyr Asn Pro Val Val Ile Asp Phe Glu Met Gln Pro Ile
    450                 455                 460                 
His Glu Val Leu Arg His Thr Ser Leu Gly Pro Leu Glu Ala Lys Arg
465                 470                 475                 480 
Gln Asn Leu Arg Arg Ala Leu Asp Gln Tyr Leu Met Glu Phe Asn Ala
                485                 490                 495     
Cys Arg Cys Gly Pro Cys Phe Asn Asn Gly Val Pro Ile Leu Glu Gly
            500                 505                 510         
Thr Ser Cys Arg Cys Gln Cys Arg Leu Gly Ser Leu Gly Ala Ala Cys
        515                 520                 525             
Glu Gln Thr Gln Thr Glu Gly Ala Lys Ala Asp Gly Ser Trp Ser Cys
    530                 535                 540                 
Trp Ser Ser Trp Ser Val Cys Arg Ala Gly Ile Gln Glu Arg Arg Arg
545                 550                 555                 560 
Glu Cys Asp Asn Pro Ala Pro Gln Asn Gly Gly Ala Ser Cys Pro Gly
                565                 570                 575     
Arg Lys Val Gln Thr Gln Ala Cys
            580                 


<210> 5480
<211> 252
<212> PRT
<213> Homo sapiens

<400> 5480
Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser
 1               5                  10                  15      
Ala Ser Asp Ala Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser
            20                  25                  30          
Ile Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val
        35                  40                  45              
Cys Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn
    50                  55                  60                  
Ala Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His
65                  70                  75                  80  
Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro
                85                  90                  95      
Val Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile
            100                 105                 110         
Leu Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala
        115                 120                 125             
Pro Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn
    130                 135                 140                 
Pro Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr
145                 150                 155                 160 
Ile Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu
                165                 170                 175     
Gln Gln Cys Val Asp Gly Glu Trp Ser Ser Ala Leu Pro Val Cys Lys
            180                 185                 190         
Leu Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala
        195                 200                 205             
Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln
    210                 215                 220                 
Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu
225                 230                 235                 240 
Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu
                245                 250         


<210> 5481
<211> 494
<212> PRT
<213> Homo sapiens

<400> 5481
Met Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln
 1               5                  10                  15      
Ile Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr
            20                  25                  30          
Asn Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met
        35                  40                  45              
Ser Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp
    50                  55                  60                  
Ala Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu
65                  70                  75                  80  
Leu Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu
                85                  90                  95      
Thr Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val
            100                 105                 110         
Ala Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val
        115                 120                 125             
Gln Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp
    130                 135                 140                 
Glu Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu
145                 150                 155                 160 
Asn His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu
                165                 170                 175     
Ala Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser
            180                 185                 190         
Gln Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr
        195                 200                 205             
Ser Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr
    210                 215                 220                 
Ile Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro
225                 230                 235                 240 
Arg Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser
                245                 250                 255     
Ser Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr
            260                 265                 270         
Asp Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys
        275                 280                 285             
Phe Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp
    290                 295                 300                 
Pro Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala
305                 310                 315                 320 
Arg Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile
                325                 330                 335     
Ala Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile
            340                 345                 350         
Thr Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln
        355                 360                 365             
Ala Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg
    370                 375                 380                 
Asn Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu
385                 390                 395                 400 
His Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe
                405                 410                 415     
Tyr Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu
            420                 425                 430         
Gly Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro
        435                 440                 445             
Gly Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Gly Phe Ala Lys
    450                 455                 460                 
Arg Leu Gln Gln Gly Pro Val Ala Trp Gly Arg Gly Val Leu Leu Val
465                 470                 475                 480 
His Ser Gln Gln Trp Gly Trp Thr His Arg Trp Cys Leu His
                485                 490                 


<210> 5482
<211> 440
<212> PRT
<213> Homo sapiens

<400> 5482
Met Gly Pro Pro Gly Ser Pro Trp Gln Trp Val Thr Leu Leu Leu Gly
 1               5                  10                  15      
Leu Leu Leu Pro Pro Ala Ala Pro Phe Trp Leu Leu Asn Val Leu Phe
            20                  25                  30          
Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro
        35                  40                  45              
Val Ile Leu Val Pro Gly Cys Leu Gly Asn Gln Leu Glu Ala Lys Leu
    50                  55                  60                  
Asp Lys Pro Asp Val Val Asn Trp Met Cys Tyr Arg Lys Thr Glu Asp
65                  70                  75                  80  
Phe Phe Thr Ile Trp Leu Asp Leu Asn Met Phe Leu Pro Leu Gly Val
                85                  90                  95      
Asp Cys Trp Ile Asp Asn Thr Arg Val Val Tyr Asn Arg Ser Ser Gly
            100                 105                 110         
Leu Val Ser Asn Ala Pro Gly Val Gln Ile Arg Val Pro Gly Phe Gly
        115                 120                 125             
Lys Thr Tyr Ser Val Glu Tyr Leu Asp Ser Ser Lys Leu Ala Gly Tyr
    130                 135                 140                 
Leu His Thr Leu Val Gln Asn Leu Val Asn Asn Gly Tyr Val Arg Asp
145                 150                 155                 160 
Glu Thr Val Arg Ala Ala Pro Tyr Asp Trp Arg Leu Glu Pro Gly Gln
                165                 170                 175     
Gln Glu Glu Tyr Tyr Arg Lys Leu Ala Gly Leu Val Glu Glu Met His
            180                 185                 190         
Ala Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys
        195                 200                 205             
Leu His Leu Leu Tyr Phe Leu Leu Arg Gln Pro Gln Ala Trp Lys Asp
    210                 215                 220                 
Arg Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser
225                 230                 235                 240 
Ile Lys Pro Met Leu Val Leu Ala Ser Gly Asp Asn Gln Gly Ile Pro
                245                 250                 255     
Ile Met Ser Ser Ile Lys Leu Lys Glu Glu Gln Arg Ile Thr Thr Thr
            260                 265                 270         
Ser Pro Trp Met Phe Pro Ser Arg Met Ala Trp Pro Glu Asp His Val
        275                 280                 285             
Phe Ile Ser Thr Pro Ser Phe Asn Tyr Thr Gly Arg Asp Phe Gln Arg
    290                 295                 300                 
Phe Phe Ala Asp Leu His Phe Glu Glu Gly Trp Tyr Met Trp Leu Gln
305                 310                 315                 320 
Ser Arg Asp Leu Leu Ala Gly Leu Pro Ala Pro Gly Val Glu Val Tyr
                325                 330                 335     
Cys Leu Tyr Gly Val Gly Leu Pro Thr Pro Arg Thr Tyr Ile Tyr Asp
            340                 345                 350         
His Gly Phe Pro Tyr Thr Asp Pro Val Gly Val Leu Tyr Glu Asp Gly
        355                 360                 365             
Asp Asp Thr Val Ala Thr Arg Ser Thr Glu Leu Cys Gly Leu Trp Gln
    370                 375                 380                 
Gly Arg Gln Pro Gln Pro Val His Leu Leu Pro Leu His Gly Ile Gln
385                 390                 395                 400 
His Leu Asn Met Val Phe Ser Asn Leu Thr Leu Glu His Ile Asn Ala
                405                 410                 415     
Ile Leu Leu Gly Ala Tyr Arg Gln Gly Pro Pro Ala Ser Pro Thr Ala
            420                 425                 430         
Ser Pro Glu Pro Pro Pro Pro Glu
        435                 440 


<210> 5483
<211> 382
<212> PRT
<213> Homo sapiens

<400> 5483
Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys
 1               5                  10                  15      
Gly Lys Leu Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu
            20                  25                  30          
Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala
        35                  40                  45              
Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu
    50                  55                  60                  
Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser
65                  70                  75                  80  
Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu
                85                  90                  95      
Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser
            100                 105                 110         
Val Tyr Gly Gln Cys Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg
        115                 120                 125             
Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys
    130                 135                 140                 
Lys Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr
145                 150                 155                 160 
Asp Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala
                165                 170                 175     
Lys Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val
            180                 185                 190         
Thr Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu
        195                 200                 205             
Tyr Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys
    210                 215                 220                 
Ser Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser
225                 230                 235                 240 
Leu Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe
                245                 250                 255     
Phe Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn
            260                 265                 270         
Gln Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn
        275                 280                 285             
Thr Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val
    290                 295                 300                 
Gln Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro
305                 310                 315                 320 
Gln Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly
                325                 330                 335     
Glu Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys
            340                 345                 350         
Leu Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys
        355                 360                 365             
Pro Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro
    370                 375                 380         


<210> 5484
<211> 423
<212> PRT
<213> Homo sapiens

<400> 5484
Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys
 1               5                  10                  15      
Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu
            20                  25                  30          
Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr
        35                  40                  45              
Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys
    50                  55                  60                  
Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val
65                  70                  75                  80  
Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala
                85                  90                  95      
Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser
            100                 105                 110         
Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu
        115                 120                 125             
Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu
    130                 135                 140                 
Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val
145                 150                 155                 160 
Leu Lys Val Ser Gly Lys Glu Gln Thr Ala Lys Asn Ala Ile Trp Ile
                165                 170                 175     
Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu
            180                 185                 190         
Trp Phe Ile Gly His Ile Thr Gln Phe Tyr Gly Ile Ile Gly Gln Tyr
        195                 200                 205             
Thr Asn Leu Leu Arg Leu Val Asp Phe Tyr Val Met Pro Val Val Asn
    210                 215                 220                 
Val Asp Gly Tyr Asp Tyr Ser Trp Lys Lys Asn Arg Met Trp Arg Lys
225                 230                 235                 240 
Asn Arg Ser Phe Tyr Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn
                245                 250                 255     
Arg Asn Phe Ala Ser Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser
            260                 265                 270         
Ser Cys Ser Glu Thr Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu
        275                 280                 285             
Val Lys Ala Val Ala Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys
    290                 295                 300                 
Ala Tyr Ile Ser Met His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr
305                 310                 315                 320 
Ser Tyr Thr Arg Ser Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val
                325                 330                 335     
Ala Ser Glu Ala Val Arg Ala Ile Glu Lys Thr Ser Lys Asn Thr Arg
            340                 345                 350         
Tyr Thr His Gly His Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly
        355                 360                 365             
Gly Asp Asp Trp Ile Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ile
    370                 375                 380                 
Glu Leu Arg Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Glu Arg Tyr
385                 390                 395                 400 
Ile Lys Pro Thr Cys Arg Glu Ala Phe Ala Ala Val Ser Lys Ile Ala
                405                 410                 415     
Trp His Val Ile Arg Asn Val
            420             


<210> 5485
<211> 360
<212> PRT
<213> Homo sapiens

<400> 5485
Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys
 1               5                  10                  15      
Glu Gln His Val Phe Ala Phe Gln Thr Gly Gln Val Leu Ala Ala Leu
            20                  25                  30          
Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr
        35                  40                  45              
Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys
    50                  55                  60                  
Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val
65                  70                  75                  80  
Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala
                85                  90                  95      
Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser
            100                 105                 110         
Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu
        115                 120                 125             
Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu
    130                 135                 140                 
Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val
145                 150                 155                 160 
Leu Lys Val Ser Gly Lys Glu Gln Ala Ala Lys Asn Ala Ile Trp Ile
                165                 170                 175     
Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu
            180                 185                 190         
Trp Phe Ile Gly His Asn Arg Met Trp Arg Lys Asn Arg Ser Phe Tyr
        195                 200                 205             
Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Ala Ser
    210                 215                 220                 
Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser Ser Cys Ser Glu Thr
225                 230                 235                 240 
Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu Val Lys Ala Val Ala
                245                 250                 255     
Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys Ala Tyr Ile Ser Met
            260                 265                 270         
His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr Ser Tyr Thr Arg Ser
        275                 280                 285             
Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val Ala Ser Glu Ala Val
    290                 295                 300                 
Arg Ala Ile Glu Lys Ile Ser Lys Asn Thr Arg Tyr Thr His Gly His
305                 310                 315                 320 
Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly Gly Asp Asp Trp Ile
                325                 330                 335     
Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ser Asn Pro Pro Val Glu
            340                 345                 350         
Lys Leu Leu Pro Leu Ser Leu Lys
        355                 360 


<210> 5486
<211> 705
<212> PRT
<213> Homo sapiens

<400> 5486
Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly
 1               5                  10                  15      
Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro
            20                  25                  30          
Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile
        35                  40                  45              
Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp
    50                  55                  60                  
Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Ile Ser Ala
65                  70                  75                  80  
Asp Lys Lys Ser Leu Gly Arg Phe Cys Gly Gln Leu Gly Ser Pro Leu
                85                  90                  95      
Gly Asn Pro Pro Gly Lys Lys Glu Phe Met Ser Gln Gly Asn Lys Met
            100                 105                 110         
Leu Leu Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly Thr Ile
        115                 120                 125             
Met Phe Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln Ala Val Asp Leu Asp
    130                 135                 140                 
Glu Cys Ala Ser Arg Ser Lys Ser Gly Glu Glu Asp Pro Gln Pro Gln
145                 150                 155                 160 
Cys Gln His Leu Cys His Asn Tyr Val Gly Gly Tyr Phe Cys Ser Cys
                165                 170                 175     
Arg Pro Gly Tyr Glu Leu Gln Glu Asp Arg His Ser Cys Gln Ala Glu
            180                 185                 190         
Cys Ser Ser Glu Leu Tyr Thr Glu Ala Ser Gly Tyr Ile Ser Ser Leu
        195                 200                 205             
Glu Tyr Pro Arg Ser Tyr Pro Pro Asp Leu Arg Cys Asn Tyr Ser Ile
    210                 215                 220                 
Arg Val Glu Arg Gly Leu Thr Leu His Leu Lys Phe Leu Glu Pro Phe
225                 230                 235                 240 
Asp Ile Asp Asp His Gln Gln Val His Cys Pro Tyr Asp Gln Leu Gln
                245                 250                 255     
Ile Tyr Ala Asn Gly Lys Asn Ile Gly Glu Phe Cys Gly Lys Gln Arg
            260                 265                 270         
Pro Pro Asp Leu Asp Thr Ser Ser Asn Ala Val Asp Leu Leu Phe Phe
        275                 280                 285             
Thr Asp Glu Ser Gly Asp Ser Arg Gly Trp Lys Leu Arg Tyr Thr Thr
    290                 295                 300                 
Glu Ile Ile Lys Cys Pro Gln Pro Lys Thr Leu Asp Glu Phe Thr Ile
305                 310                 315                 320 
Ile Gln Asn Leu Gln Pro Gln Tyr Gln Phe Arg Asp Tyr Phe Ile Ala
                325                 330                 335     
Thr Cys Lys Gln Gly Tyr Gln Leu Ile Glu Gly Asn Gln Val Leu His
            340                 345                 350         
Ser Phe Thr Ala Val Cys Gln Asp Asp Gly Thr Trp His Arg Ala Met
        355                 360                 365             
Pro Arg Cys Lys Ile Lys Asp Cys Gly Gln Pro Arg Asn Leu Pro Asn
    370                 375                 380                 
Gly Asp Phe Arg Tyr Thr Thr Thr Met Gly Val Asn Thr Tyr Lys Ala
385                 390                 395                 400 
Arg Ile Gln Tyr Tyr Cys His Glu Pro Tyr Tyr Lys Met Gln Thr Arg
                405                 410                 415     
Ala Gly Ser Arg Glu Ser Glu Gln Gly Val Tyr Thr Cys Thr Ala Gln
            420                 425                 430         
Gly Ile Trp Lys Asn Glu Gln Lys Gly Glu Lys Ile Pro Arg Cys Leu
        435                 440                 445             
Pro Val Cys Gly Lys Pro Val Asn Pro Val Glu Gln Arg Gln Arg Ile
    450                 455                 460                 
Ile Gly Gly Gln Lys Ala Lys Met Gly Asn Phe Pro Trp Gln Val Phe
465                 470                 475                 480 
Thr Asn Ile His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp
                485                 490                 495     
Ile Leu Thr Ala Ala His Thr Leu Tyr Pro Lys Glu His Glu Ala Gln
            500                 505                 510         
Ser Asn Ala Ser Leu Asp Val Phe Leu Gly His Thr Asn Val Glu Glu
        515                 520                 525             
Leu Met Lys Leu Gly Asn His Pro Ile Arg Arg Val Ser Val His Pro
    530                 535                 540                 
Asp Tyr Arg Gln Asp Glu Ser Tyr Asn Phe Glu Gly Asp Ile Ala Leu
545                 550                 555                 560 
Leu Glu Leu Glu Asn Ser Val Thr Leu Gly Pro Asn Leu Leu Pro Ile
                565                 570                 575     
Cys Leu Pro Asp Asn Asp Thr Phe Tyr Asp Leu Gly Leu Met Gly Tyr
            580                 585                 590         
Val Ser Gly Phe Gly Val Met Glu Glu Lys Ile Ala His Asp Leu Arg
        595                 600                 605             
Phe Val Arg Leu Pro Val Ala Asn Pro Gln Ala Cys Glu Asn Trp Leu
    610                 615                 620                 
Arg Gly Lys Asn Arg Met Asp Val Phe Ser Gln Asn Met Phe Cys Ala
625                 630                 635                 640 
Gly His Pro Ser Leu Lys Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly
                645                 650                 655     
Val Phe Ala Val Arg Asp Pro Asn Thr Asp Arg Trp Val Ala Thr Gly
            660                 665                 670         
Ile Val Ser Trp Gly Ile Gly Cys Ser Arg Gly Tyr Gly Phe Tyr Thr
        675                 680                 685             
Lys Val Leu Asn Tyr Val Asp Trp Ile Lys Lys Glu Met Glu Glu Glu
    690                 695                 700                 
Asp
705 


<210> 5487
<211> 585
<212> PRT
<213> Homo sapiens

<400> 5487
Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr
 1               5                  10                  15      
Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr
            20                  25                  30          
Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val
        35                  40                  45              
Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala
    50                  55                  60                  
Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly
65                  70                  75                  80  
Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr
                85                  90                  95      
Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn
            100                 105                 110         
Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg
        115                 120                 125             
Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly
    130                 135                 140                 
Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn
145                 150                 155                 160 
Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu
                165                 170                 175     
Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn
            180                 185                 190         
Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu
        195                 200                 205             
Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val
    210                 215                 220                 
Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln
225                 230                 235                 240 
Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser
                245                 250                 255     
Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp
            260                 265                 270         
Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu
        275                 280                 285             
Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu
    290                 295                 300                 
Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala
305                 310                 315                 320 
Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His
                325                 330                 335     
Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu
            340                 345                 350         
Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser
        355                 360                 365             
His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His
    370                 375                 380                 
Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr
385                 390                 395                 400 
Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala
                405                 410                 415     
Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr
            420                 425                 430         
Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln
        435                 440                 445             
Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro
    450                 455                 460                 
Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu
465                 470                 475                 480 
Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys
                485                 490                 495     
Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser
            500                 505                 510         
Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly
        515                 520                 525             
Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile
    530                 535                 540                 
Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro
545                 550                 555                 560 
Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe
                565                 570                 575     
Tyr Leu Thr Asn Ser Ser Gly Val Asp
            580                 585 


<210> 5488
<211> 688
<212> PRT
<213> Homo sapiens

<400> 5488
Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu
 1               5                  10                  15      
Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr
            20                  25                  30          
Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr
        35                  40                  45              
Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn
    50                  55                  60                  
Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly
65                  70                  75                  80  
Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val
                85                  90                  95      
Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser
            100                 105                 110         
Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val
        115                 120                 125             
Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser
    130                 135                 140                 
His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro
145                 150                 155                 160 
Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys Ser
                165                 170                 175     
Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn Tyr
            180                 185                 190         
Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg Leu
        195                 200                 205             
Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe Asp
    210                 215                 220                 
Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val Phe
225                 230                 235                 240 
Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro
                245                 250                 255     
Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe
            260                 265                 270         
Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His
        275                 280                 285             
Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val Trp
    290                 295                 300                 
Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile Thr
305                 310                 315                 320 
Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr Ser
                325                 330                 335     
Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys Leu
            340                 345                 350         
Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly
        355                 360                 365             
Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr
    370                 375                 380                 
Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu
385                 390                 395                 400 
Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro
                405                 410                 415     
Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro Phe
            420                 425                 430         
Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn
        435                 440                 445             
Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu
    450                 455                 460                 
Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly Asn
465                 470                 475                 480 
Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg
                485                 490                 495     
Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro
            500                 505                 510         
Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn
        515                 520                 525             
Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr
    530                 535                 540                 
Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met
545                 550                 555                 560 
Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg
                565                 570                 575     
Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro Leu
            580                 585                 590         
Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala Glu
        595                 600                 605             
Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly
    610                 615                 620                 
Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp
625                 630                 635                 640 
Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly
                645                 650                 655     
Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val
            660                 665                 670         
Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp
        675                 680                 685             


<210> 5489
<211> 752
<212> PRT
<213> Homo sapiens

<400> 5489
Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly
 1               5                  10                  15      
Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly
            20                  25                  30          
Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr
        35                  40                  45              
Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys
    50                  55                  60                  
Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser
65                  70                  75                  80  
Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu
                85                  90                  95      
Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn
            100                 105                 110         
Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val
        115                 120                 125             
Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys
    130                 135                 140                 
Asp Asn Gly Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala
145                 150                 155                 160 
Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg
                165                 170                 175     
Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln
            180                 185                 190         
Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr
        195                 200                 205             
Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe
    210                 215                 220                 
Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser
225                 230                 235                 240 
Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr
                245                 250                 255     
Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile
            260                 265                 270         
Phe Lys Glu Ser Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu
        275                 280                 285             
Ile Asn Val Ser Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val
    290                 295                 300                 
Leu Met Ser Val Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile
305                 310                 315                 320 
Ser Ser Leu Glu Asn Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly
                325                 330                 335     
Thr Asn Thr Tyr Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn
            340                 345                 350         
Gln Met Arg Leu Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg
        355                 360                 365             
His Ala Ile Ile Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser
    370                 375                 380                 
Pro Lys Thr Ala Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln
385                 390                 395                 400 
Lys Arg Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu
                405                 410                 415     
Asp Val Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly
            420                 425                 430         
Glu Arg His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val
        435                 440                 445             
Phe Glu His Met Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly
    450                 455                 460                 
Val Gly Asn Met Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp
465                 470                 475                 480 
His Val Thr Ile Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu
                485                 490                 495     
Ile Ser Asp Gln Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly
            500                 505                 510         
Asn Asp His Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln
        515                 520                 525             
Trp Gly Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe
    530                 535                 540                 
Asp Val Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp
545                 550                 555                 560 
Asp Ile Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His
                565                 570                 575     
Ala Arg Pro Ile Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu
            580                 585                 590         
Arg Arg Pro Gln Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu
        595                 600                 605             
Asn Lys Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys
    610                 615                 620                 
Leu Asn Ile Asn Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu
625                 630                 635                 640 
Val Val Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg
                645                 650                 655     
Glu Val Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu
            660                 665                 670         
Ser Pro Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg
        675                 680                 685             
Phe Arg Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro
    690                 695                 700                 
Cys Leu Gly Ser Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser
705                 710                 715                 720 
Lys Val Pro Pro Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln
                725                 730                 735     
Pro Trp Leu Arg Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu
            740                 745                 750         


<210> 5490
<211> 493
<212> PRT
<213> Homo sapiens

<400> 5490
Met Ala Leu Phe Gly Ala Leu Phe Leu Ala Leu Leu Ala Gly Ala His
 1               5                  10                  15      
Ala Glu Phe Pro Gly Cys Lys Ile Arg Val Thr Ser Lys Ala Leu Glu
            20                  25                  30          
Leu Val Lys Gln Glu Gly Leu Arg Phe Leu Glu Gln Glu Leu Glu Thr
        35                  40                  45              
Ile Thr Ile Pro Asp Leu Arg Gly Lys Glu Gly His Phe Tyr Tyr Asn
    50                  55                  60                  
Ile Ser Glu Val Lys Val Thr Glu Leu Gln Leu Thr Ser Ser Glu Leu
65                  70                  75                  80  
Asp Phe Gln Pro Gln Gln Glu Leu Met Leu Gln Ile Thr Asn Ala Ser
                85                  90                  95      
Leu Gly Leu Arg Phe Arg Arg Gln Leu Leu Tyr Trp Phe Phe Tyr Asp
            100                 105                 110         
Gly Gly Tyr Ile Asn Ala Ser Ala Glu Gly Val Ser Ile Arg Thr Gly
        115                 120                 125             
Leu Glu Leu Ser Arg Asp Pro Ala Gly Arg Met Lys Val Ser Asn Val
    130                 135                 140                 
Ser Cys Gln Ala Ser Val Ser Arg Met His Ala Ala Phe Gly Gly Thr
145                 150                 155                 160 
Phe Lys Lys Val Tyr Asp Phe Leu Ser Thr Phe Ile Thr Ser Gly Met
                165                 170                 175     
Arg Phe Leu Leu Asn Gln Gln Ile Cys Pro Val Leu Tyr His Ala Gly
            180                 185                 190         
Thr Val Leu Leu Asn Ser Leu Leu Asp Thr Val Pro Val Arg Ser Ser
        195                 200                 205             
Val Asp Glu Leu Val Gly Ile Asp Tyr Ser Leu Met Lys Asp Pro Val
    210                 215                 220                 
Ala Ser Thr Ser Asn Leu Asp Met Asp Phe Arg Gly Ala Phe Phe Pro
225                 230                 235                 240 
Leu Thr Glu Arg Asn Trp Ser Leu Pro Asn Arg Ala Val Glu Pro Gln
                245                 250                 255     
Leu Gln Glu Glu Glu Arg Met Val Tyr Val Ala Phe Ser Glu Phe Phe
            260                 265                 270         
Phe Asp Ser Ala Met Glu Ser Tyr Phe Arg Ala Gly Ala Leu Gln Leu
        275                 280                 285             
Leu Leu Val Gly Asp Lys Val Pro His Asp Leu Asp Met Leu Leu Arg
    290                 295                 300                 
Ala Thr Tyr Phe Gly Ser Ile Val Leu Leu Ser Pro Ala Val Ile Asp
305                 310                 315                 320 
Ser Pro Leu Lys Leu Glu Leu Arg Val Leu Ala Pro Pro Arg Cys Thr
                325                 330                 335     
Ile Lys Pro Ser Gly Thr Thr Ile Ser Val Thr Ala Ser Val Thr Ile
            340                 345                 350         
Ala Leu Val Pro Pro Asp Gln Pro Glu Val Gln Leu Ser Ser Met Thr
        355                 360                 365             
Met Asp Ala Arg Leu Ser Ala Lys Met Ala Leu Arg Gly Lys Ala Leu
    370                 375                 380                 
Arg Thr Gln Leu Asp Leu Arg Arg Phe Arg Ile Tyr Ser Asn His Ser
385                 390                 395                 400 
Ala Leu Glu Ser Leu Ala Leu Ile Pro Leu Gln Ala Pro Leu Lys Thr
                405                 410                 415     
Met Leu Gln Ile Gly Val Met Pro Met Leu Asn Glu Arg Thr Trp Arg
            420                 425                 430         
Gly Val Gln Ile Pro Leu Pro Glu Gly Ile Asn Phe Val His Glu Val
        435                 440                 445             
Val Thr Asn His Ala Gly Phe Leu Thr Ile Gly Ala Asp Leu His Phe
    450                 455                 460                 
Ala Lys Gly Leu Arg Glu Val Ile Glu Lys Asn Arg Pro Ala Asp Val
465                 470                 475                 480 
Arg Ala Ser Thr Ala Pro Thr Pro Ser Thr Ala Ala Val
                485                 490             


<210> 5491
<211> 441
<212> PRT
<213> Homo sapiens

<400> 5491
Met Ala Leu Phe Gly Ala Leu Phe Leu Ala Leu Leu Ala Gly Ala His
 1               5                  10                  15      
Ala Glu Phe Pro Gly Cys Lys Ile Arg Val Thr Ser Lys Ala Leu Glu
            20                  25                  30          
Leu Val Lys Gln Glu Gly Leu Arg Phe Leu Glu Gln Glu Leu Glu Thr
        35                  40                  45              
Ile Thr Ile Pro Asp Leu Arg Gly Lys Glu Gly His Phe Tyr Tyr Asn
    50                  55                  60                  
Ile Ser Glu Val Lys Val Thr Glu Leu Gln Leu Thr Ser Ser Glu Leu
65                  70                  75                  80  
Asp Phe Gln Pro Gln Gln Glu Leu Met Leu Gln Ile Thr Asn Ala Ser
                85                  90                  95      
Leu Gly Leu Arg Phe Arg Arg Gln Leu Leu Tyr Trp Phe Leu Lys Val
            100                 105                 110         
Tyr Asp Phe Leu Ser Thr Phe Ile Thr Ser Gly Met Arg Phe Leu Leu
        115                 120                 125             
Asn Gln Gln Ile Cys Pro Val Leu Tyr His Ala Gly Thr Val Leu Leu
    130                 135                 140                 
Asn Ser Leu Leu Asp Thr Val Pro Val Arg Ser Ser Val Asp Glu Leu
145                 150                 155                 160 
Val Gly Ile Asp Tyr Ser Leu Met Lys Asp Pro Val Ala Ser Thr Ser
                165                 170                 175     
Asn Leu Asp Met Asp Phe Arg Gly Ala Phe Phe Pro Leu Thr Glu Arg
            180                 185                 190         
Asn Trp Ser Leu Pro Asn Arg Ala Val Glu Pro Gln Leu Gln Glu Glu
        195                 200                 205             
Glu Arg Met Val Tyr Val Ala Phe Ser Glu Phe Phe Phe Asp Ser Ala
    210                 215                 220                 
Met Glu Ser Tyr Phe Arg Ala Gly Ala Leu Gln Leu Leu Leu Val Gly
225                 230                 235                 240 
Asp Lys Val Pro His Asp Leu Asp Met Leu Leu Arg Ala Thr Tyr Phe
                245                 250                 255     
Gly Ser Ile Val Leu Leu Ser Pro Ala Val Ile Asp Ser Pro Leu Lys
            260                 265                 270         
Leu Glu Leu Arg Val Leu Ala Pro Pro Arg Cys Thr Ile Lys Pro Ser
        275                 280                 285             
Gly Thr Thr Ile Ser Val Thr Ala Ser Val Thr Ile Ala Leu Val Pro
    290                 295                 300                 
Pro Asp Gln Pro Glu Val Gln Leu Ser Ser Met Thr Met Asp Ala Arg
305                 310                 315                 320 
Leu Ser Ala Lys Met Ala Leu Arg Gly Lys Ala Leu Arg Thr Gln Leu
                325                 330                 335     
Asp Leu Arg Arg Phe Arg Ile Tyr Ser Asn His Ser Ala Leu Glu Ser
            340                 345                 350         
Leu Ala Leu Ile Pro Leu Gln Ala Pro Leu Lys Thr Met Leu Gln Ile
        355                 360                 365             
Gly Val Met Pro Met Leu Asn Glu Arg Thr Trp Arg Gly Val Gln Ile
    370                 375                 380                 
Pro Leu Pro Glu Gly Ile Asn Phe Val His Glu Val Val Thr Asn His
385                 390                 395                 400 
Ala Gly Phe Leu Thr Ile Gly Ala Asp Leu His Phe Ala Lys Gly Leu
                405                 410                 415     
Arg Glu Val Ile Glu Lys Asn Arg Pro Ala Asp Val Arg Ala Ser Thr
            420                 425                 430         
Ala Pro Thr Pro Ser Thr Ala Ala Val
        435                 440     


<210> 5492
<211> 291
<212> PRT
<213> Homo sapiens

<400> 5492
Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu
 1               5                  10                  15      
Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Gly
            20                  25                  30          
Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu
        35                  40                  45              
Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu
    50                  55                  60                  
Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro
65                  70                  75                  80  
Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro
                85                  90                  95      
Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly
            100                 105                 110         
Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu
        115                 120                 125             
Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg
    130                 135                 140                 
Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val
145                 150                 155                 160 
Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys
                165                 170                 175     
Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser
            180                 185                 190         
Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr
        195                 200                 205             
Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu
    210                 215                 220                 
Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys
225                 230                 235                 240 
Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly
                245                 250                 255     
Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu
            260                 265                 270         
Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met
        275                 280                 285             
Gln Ser Lys
    290     


<210> 5493
<211> 487
<212> PRT
<213> Homo sapiens

<400> 5493
Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser Pro His
 1               5                  10                  15      
Ser Lys Gly Cys Pro Gly Ala Met Trp Trp Leu Leu Leu Trp Gly Val
            20                  25                  30          
Leu Gln Ala Cys Pro Thr Arg Gly Ser Val Leu Leu Ala Gln Glu Leu
        35                  40                  45              
Pro Gln Gln Leu Thr Ser Pro Gly Tyr Pro Glu Pro Tyr Gly Lys Gly
    50                  55                  60                  
Gln Glu Ser Ser Thr Asp Ile Lys Ala Pro Glu Gly Phe Ala Val Arg
65                  70                  75                  80  
Leu Val Phe Gln Asp Phe Asp Leu Glu Pro Ser Gln Asp Cys Ala Gly
                85                  90                  95      
Asp Ser Val Thr Ile Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys
            100                 105                 110         
Gly Gln Gln Gly Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe
        115                 120                 125             
Val Ser Ser Gly Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro Ser
    130                 135                 140                 
Ser Glu Asn Lys Thr Ala His Leu His Lys Gly Phe Leu Ala Leu Tyr
145                 150                 155                 160 
Gln Thr Val Ala Val Asn Tyr Ser Gln Pro Ile Ser Glu Ala Ser Arg
                165                 170                 175     
Gly Ser Glu Ala Ile Asn Ala Pro Gly Asp Asn Pro Ala Lys Val Gln
            180                 185                 190         
Asn His Cys Gln Glu Pro Tyr Tyr Gln Ala Ala Ala Ala Gly Ala Leu
        195                 200                 205             
Thr Cys Ala Thr Pro Gly Thr Trp Lys Asp Arg Gln Asp Gly Glu Glu
    210                 215                 220                 
Val Leu Gln Cys Met Pro Val Cys Gly Arg Pro Val Thr Pro Ile Ala
225                 230                 235                 240 
Gln Asn Gln Thr Thr Leu Gly Ser Ser Arg Ala Lys Leu Gly Asn Phe
                245                 250                 255     
Pro Trp Gln Ala Phe Thr Ser Ile His Gly Arg Gly Gly Gly Ala Leu
            260                 265                 270         
Leu Gly Asp Arg Trp Ile Leu Thr Ala Ala His Thr Val Tyr Pro Lys
        275                 280                 285             
Asp Ser Val Ser Leu Arg Lys Asn Gln Ser Val Asn Val Phe Leu Gly
    290                 295                 300                 
His Thr Ala Ile Asp Glu Met Leu Lys Leu Gly Asn His Pro Val His
305                 310                 315                 320 
Arg Val Val Val His Pro Asp Tyr Arg Gln Asn Glu Ser His Asn Phe
                325                 330                 335     
Ser Gly Asp Ile Ala Leu Leu Glu Leu Gln His Ser Ile Pro Leu Gly
            340                 345                 350         
Pro Asn Val Leu Pro Val Cys Leu Pro Asp Asn Glu Thr Leu Tyr Arg
        355                 360                 365             
Ser Gly Leu Leu Gly Tyr Val Ser Gly Phe Gly Met Glu Met Gly Trp
    370                 375                 380                 
Leu Thr Thr Glu Leu Lys Tyr Ser Arg Leu Pro Val Ala Pro Arg Glu
385                 390                 395                 400 
Ala Cys Asn Ala Trp Leu Gln Lys Arg Gln Arg Pro Glu Val Phe Ser
                405                 410                 415     
Asp Asn Met Phe Cys Val Gly Asp Glu Thr Gln Arg His Ser Val Cys
            420                 425                 430         
Gln Gly Asp Ser Gly Ser Val Tyr Val Val Trp Asp Asn His Ala His
        435                 440                 445             
His Trp Val Ala Thr Gly Ile Val Ser Trp Gly Ile Gly Cys Gly Glu
    450                 455                 460                 
Gly Tyr Asp Phe Tyr Thr Lys Val Leu Ser Tyr Val Asp Trp Ile Lys
465                 470                 475                 480 
Gly Val Met Asn Gly Lys Asn
                485         


<210> 5494
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5494
Met Ala Leu Leu Trp Gly Leu Leu Val Leu Ser Trp Ser Cys Leu Gln
 1               5                  10                  15      
Gly Pro Cys Ser Val Phe Ser Pro Val Ser Ala Met Glu Pro Leu Gly
            20                  25                  30          
Arg Gln Leu Thr Ser Gly Pro Asn Gln Glu Gln Val Ser Pro Leu Thr
        35                  40                  45              
Leu Leu Lys Leu Gly Asn Gln Glu Pro Gly Gly Gln Thr Ala Leu Lys
    50                  55                  60                  
Ser Pro Pro Gly Val Cys Ser Arg Asp Pro Thr Pro Glu Gln Thr His
65                  70                  75                  80  
Arg Leu Ala Arg Ala Met Met Ala Phe Thr Ala Asp Leu Phe Ser Leu
                85                  90                  95      
Val Ala Gln Thr Ser Thr Cys Pro Asn Leu Ile Leu Ser Pro Leu Ser
            100                 105                 110         
Val Ala Leu Ala Leu Ser His Leu Ala Leu Gly Ala Gln Asn His Thr
        115                 120                 125             
Leu Gln Arg Leu Gln Gln Val Leu His Ala Gly Ser Gly Pro Cys Leu
    130                 135                 140                 
Pro His Leu Leu Ser Arg Leu Cys Gln Asp Leu Gly Pro Gly Ala Phe
145                 150                 155                 160 
Arg Leu Ala Ala Arg Met Tyr Leu Gln Lys Gly Phe Pro Ile Lys Glu
                165                 170                 175     
Asp Phe Leu Glu Gln Ser Glu Gln Leu Phe Gly Ala Lys Pro Val Ser
            180                 185                 190         
Leu Thr Gly Lys Gln Glu Asp Asp Leu Ala Asn Ile Asn Gln Trp Val
        195                 200                 205             
Lys Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu Ser Gly Leu Pro
    210                 215                 220                 
Glu Asp Thr Val Leu Leu Leu Leu Asn Ala Ile His Phe Gln Gly Phe
225                 230                 235                 240 
Trp Arg Asn Lys Phe Asp Pro Ser Leu Thr Gln Arg Asp Ser Phe His
                245                 250                 255     
Leu Asp Glu Gln Phe Thr Val Pro Val Glu Met Met Gln Ala Arg Thr
            260                 265                 270         
Tyr Pro Leu Arg Trp Phe Leu Leu Glu Gln Pro Glu Ile Gln Val Ala
        275                 280                 285             
His Phe Pro Phe Lys Asn Asn Met Ser Phe Val Val Leu Val Pro Thr
    290                 295                 300                 
His Phe Glu Trp Asn Val Ser Gln Val Leu Ala Asn Leu Ser Trp Asp
305                 310                 315                 320 
Thr Leu His Pro Pro Leu Val Trp Glu Arg Pro Thr Lys Val Arg Leu
                325                 330                 335     
Pro Lys Leu Tyr Leu Lys His Gln Met Asp Leu Val Ala Thr Leu Ser
            340                 345                 350         
Gln Leu Gly Leu Gln Glu Leu Phe Gln Ala Pro Asp Leu Arg Gly Ile
        355                 360                 365             
Ser Glu Gln Ser Leu Val Val Ser Gly Val Gln His Gln Ser Thr Leu
    370                 375                 380                 
Glu Leu Ser Glu Val Gly Val Glu Ala Ala Ala Ala Thr Ser Ile Ala
385                 390                 395                 400 
Met Ser Arg Met Ser Leu Ser Ser Phe Ser Val Asn Arg Pro Phe Leu
                405                 410                 415     
Phe Phe Ile Phe Glu Asp Thr Thr Gly Leu Pro Leu Phe Val Gly Ser
            420                 425                 430         
Val Arg Asn Pro Asn Pro Ser Ala Pro Arg Glu Leu Lys Glu Gln Gln
        435                 440                 445             
Asp Ser Pro Gly Asn Lys Asp Phe Leu Gln Ser Leu Lys Gly Phe Pro
    450                 455                 460                 
Arg Gly Asp Lys Leu Phe Gly Pro Asp Leu Lys Leu Val Pro Pro Met
465                 470                 475                 480 
Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys
                485                 490     


<210> 5495
<211> 1236
<212> PRT
<213> Homo sapiens

<400> 5495
Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr
 1               5                  10                  15      
Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp
            20                  25                  30          
Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg
        35                  40                  45              
Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu
    50                  55                  60                  
Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu
65                  70                  75                  80  
Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala
                85                  90                  95      
Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn
            100                 105                 110         
Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln
        115                 120                 125             
Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe
    130                 135                 140                 
Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp
145                 150                 155                 160 
Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His
                165                 170                 175     
Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp
            180                 185                 190         
Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro
        195                 200                 205             
Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly
    210                 215                 220                 
Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly
225                 230                 235                 240 
Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly
                245                 250                 255     
Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu
            260                 265                 270         
Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr
        275                 280                 285             
Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val
    290                 295                 300                 
Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val
305                 310                 315                 320 
Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn
                325                 330                 335     
Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile
            340                 345                 350         
Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met
        355                 360                 365             
Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg
    370                 375                 380                 
Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr
385                 390                 395                 400 
Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn
                405                 410                 415     
Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val
            420                 425                 430         
Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser
        435                 440                 445             
Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile
    450                 455                 460                 
Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr
465                 470                 475                 480 
Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu
                485                 490                 495     
Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg
            500                 505                 510         
Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr
        515                 520                 525             
Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp
    530                 535                 540                 
Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val
545                 550                 555                 560 
Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp
                565                 570                 575     
Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala
            580                 585                 590         
Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu
        595                 600                 605             
His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser
    610                 615                 620                 
Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile
625                 630                 635                 640 
Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala
                645                 650                 655     
Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Leu Leu Thr Met Thr Asp
            660                 665                 670         
Val Thr Ser Thr Gln Ile Val Thr Ala Ala Gln Pro Thr Pro Met Thr
        675                 680                 685             
Ala Thr Gly Ala Met Thr Ile Val Ser Pro Gly Thr Thr Ala Ala Gln
    690                 695                 700                 
Lys Ala Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro Met Tyr Tyr Cys
705                 710                 715                 720 
Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp Gln Asn Cys Gln
                725                 730                 735     
Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro Glu Asn Ile Cys
            740                 745                 750         
Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu Lys Ile Thr Thr
        755                 760                 765             
Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys Arg Asn His Asn
    770                 775                 780                 
Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val Glu Phe Val Leu
785                 790                 795                 800 
Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met Ser Lys Leu Thr
                805                 810                 815     
Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val Ser Tyr Trp Cys
            820                 825                 830         
Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu Gln Trp Met Pro
        835                 840                 845             
Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu Ser Glu Pro Ser
    850                 855                 860                 
Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro Leu Asn Gly Ser
865                 870                 875                 880 
Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln Cys Arg Thr Pro
                885                 890                 895     
Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser Gly Ser Ser Glu
            900                 905                 910         
Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp Ser Asn Ala Tyr
        915                 920                 925             
Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp Tyr Thr Met Ser
    930                 935                 940                 
Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr Cys Ser His Cys
945                 950                 955                 960 
Leu Glu Gln Pro Gly Cys Gly Trp Cys Thr Asp Pro Ser Asn Thr Gly
                965                 970                 975     
Lys Gly Lys Cys Ile Glu Gly Ser Tyr Lys Gly Pro Val Lys Met Pro
            980                 985                 990         
Ser Gln Ala Pro Thr Gly Asn Phe Tyr Pro Gln Pro Leu Leu Asn Ser
        995                 1000                1005            
Ser Met Cys Leu Glu Asp Ser Arg Tyr Asn Trp Ser Phe Ile His Cys
    1010                1015                1020                
Pro Ala Cys Gln Cys Asn Gly His Ser Lys Cys Ile Asn Gln Ser Ile
1025                1030                1035                1040
Cys Glu Lys Cys Glu Asn Leu Thr Thr Gly Lys His Cys Glu Thr Cys
                1045                1050                1055    
Ile Ser Gly Phe Tyr Gly Asp Pro Thr Asn Gly Gly Lys Cys Gln Pro
            1060                1065                1070        
Cys Lys Cys Asn Gly His Ala Ser Leu Cys Asn Thr Asn Thr Gly Lys
        1075                1080                1085            
Cys Phe Cys Thr Thr Lys Gly Val Lys Gly Asp Glu Cys Gln Leu Cys
    1090                1095                1100                
Glu Val Glu Asn Arg Tyr Gln Gly Asn Pro Leu Arg Gly Thr Cys Tyr
1105                1110                1115                1120
Tyr Thr Leu Leu Ile Asp Tyr Gln Phe Thr Phe Ser Leu Ser Gln Glu
                1125                1130                1135    
Asp Asp Arg Tyr Tyr Thr Ala Ile Asn Phe Val Ala Thr Pro Asp Glu
            1140                1145                1150        
Gln Asn Arg Asp Leu Asp Met Phe Ile Asn Ala Ser Lys Asn Phe Asn
        1155                1160                1165            
Leu Asn Ile Thr Trp Ala Ala Ser Phe Ser Ala Gly Thr Gln Ala Gly
    1170                1175                1180                
Glu Glu Met Pro Val Val Ser Lys Thr Asn Ile Lys Glu Tyr Lys Asp
1185                1190                1195                1200
Ser Phe Ser Asn Glu Lys Phe Asp Phe Arg Asn His Pro Asn Ile Thr
                1205                1210                1215    
Phe Phe Val Tyr Val Ser Asn Phe Thr Trp Pro Ile Lys Ile Gln Val
            1220                1225                1230        
Gln Thr Glu Gln
        1235    


<210> 5496
<211> 1198
<212> PRT
<213> Homo sapiens

<400> 5496
Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr
 1               5                  10                  15      
Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Cys Val
            20                  25                  30          
Asn Gly Gly Arg Cys Asn Pro Gly Thr Gly Gln Cys Val Cys Pro Ala
        35                  40                  45              
Gly Trp Val Gly Glu Gln Cys Gln His Cys Gly Gly Arg Phe Arg Leu
    50                  55                  60                  
Thr Gly Ser Ser Gly Phe Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr
65                  70                  75                  80  
Lys Thr Lys Cys Thr Trp Leu Ile Glu Gly Gln Pro Asn Arg Ile Met
                85                  90                  95      
Arg Leu Arg Phe Asn His Phe Ala Thr Glu Cys Ser Trp Asp His Leu
            100                 105                 110         
Tyr Val Tyr Asp Gly Asp Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe
        115                 120                 125             
Ser Gly Leu Ile Val Pro Glu Arg Asp Gly Asn Glu Thr Val Pro Glu
    130                 135                 140                 
Val Val Ala Thr Ser Gly Tyr Ala Leu Leu His Phe Phe Ser Asp Ala
145                 150                 155                 160 
Ala Tyr Asn Leu Thr Gly Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys
                165                 170                 175     
Pro Asn Asn Cys Ser Gly Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser
            180                 185                 190         
Asp Thr Val Glu Cys Glu Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys
        195                 200                 205             
Asp Ile Pro His Cys Thr Asp Asn Cys Gly Phe Pro His Arg Gly Ile
    210                 215                 220                 
Cys Asn Ser Ser Asp Val Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln
225                 230                 235                 240 
Gly Pro Gly Cys Ser Val Pro Val Pro Ala Asn Gln Ser Phe Trp Thr
                245                 250                 255     
Arg Glu Glu Tyr Ser Asn Leu Lys Leu Pro Arg Ala Ser His Lys Ala
            260                 265                 270         
Val Val Asn Gly Asn Ile Met Trp Val Val Gly Gly Tyr Met Phe Asn
        275                 280                 285             
His Ser Asp Tyr Asn Met Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu
    290                 295                 300                 
Trp Leu Pro Leu Asn Arg Ser Val Asn Asn Val Val Val Arg Tyr Gly
305                 310                 315                 320 
His Ser Leu Ala Leu Tyr Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys
                325                 330                 335     
Ile Asp Ser Thr Gly Asn Val Thr Asn Glu Leu Arg Val Phe His Ile
            340                 345                 350         
His Asn Glu Ser Trp Val Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr
        355                 360                 365             
Ala Val Val Gly His Ser Ala His Ile Val Thr Leu Lys Asn Gly Arg
    370                 375                 380                 
Val Val Met Leu Val Ile Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile
385                 390                 395                 400 
Ser Asn Val Gln Glu Tyr Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu
                405                 410                 415     
His Thr Gln Gly Ala Leu Val Gln Gly Gly Tyr Gly His Ser Ser Val
            420                 425                 430         
Tyr Asp His Arg Thr Arg Ala Leu Tyr Val His Gly Gly Tyr Lys Ala
        435                 440                 445             
Phe Ser Ala Asn Lys Tyr Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp
    450                 455                 460                 
Val Asp Thr Gln Met Trp Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg
465                 470                 475                 480 
Tyr Leu His Thr Ala Val Ile Val Ser Gly Thr Met Leu Val Phe Gly
                485                 490                 495     
Gly Asn Thr His Asn Asp Thr Ser Met Ser His Gly Ala Lys Cys Phe
            500                 505                 510         
Ser Ser Asp Phe Met Ala Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val
        515                 520                 525             
Leu Pro Arg Pro Asp Ser Thr Met Met Ser Thr Asp Leu Ala Ile Pro
    530                 535                 540                 
Ala Val Leu His Asn Ser Thr Met Tyr Val Phe Gly Gly Phe Asn Ser
545                 550                 555                 560 
Leu Leu Leu Ser Asp Ile Leu Val Phe Thr Ser Glu Gln Cys Asp Ala
                565                 570                 575     
His Arg Ser Glu Ala Ala Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys
            580                 585                 590         
Val Trp Asn Thr Gly Ser Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr
        595                 600                 605             
Asp Glu Gln Glu Glu Lys Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr
    610                 615                 620                 
Leu Asp His Asp Arg Cys Asp Gln His Thr Asp Cys Tyr Ser Cys Thr
625                 630                 635                 640 
Ala Asn Thr Asn Asp Cys His Trp Cys Asn Asp His Cys Val Pro Arg
                645                 650                 655     
Asn His Ser Cys Ser Glu Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn
            660                 665                 670         
Cys Pro Lys Asp Asn Pro Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys
        675                 680                 685             
Arg Ser Cys Ala Leu Asp Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln
    690                 695                 700                 
Glu Cys Ile Ala Leu Pro Glu Asn Ile Cys Gly Ile Gly Trp His Leu
705                 710                 715                 720 
Val Gly Asn Ser Cys Leu Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp
                725                 730                 735     
Asn Ala Lys Leu Phe Cys Arg Asn His Asn Ala Leu Leu Ala Ser Leu
            740                 745                 750         
Thr Thr Gln Lys Lys Val Glu Phe Val Leu Lys Gln Leu Arg Ile Met
        755                 760                 765             
Gln Ser Ser Gln Ser Met Ser Lys Leu Thr Leu Thr Pro Trp Val Gly
    770                 775                 780                 
Leu Arg Lys Ile Asn Val Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro
785                 790                 795                 800 
Phe Thr Asn Ser Leu Leu Gln Trp Met Pro Ser Glu Pro Ser Asp Ala
                805                 810                 815     
Gly Phe Cys Gly Ile Leu Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala
            820                 825                 830         
Ala Thr Cys Ile Asn Pro Leu Asn Gly Ser Val Cys Glu Arg Pro Ala
        835                 840                 845             
Asn His Ser Ala Lys Gln Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala
    850                 855                 860                 
Cys Gly Asp Cys Thr Ser Gly Ser Ser Glu Cys Met Trp Cys Ser Asn
865                 870                 875                 880 
Met Lys Gln Cys Val Asp Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe
                885                 890                 895     
Gly Gln Cys Met Glu Trp Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn
            900                 905                 910         
Cys Ser Gly Tyr Cys Thr Cys Ser His Cys Leu Glu Gln Pro Gly Cys
        915                 920                 925             
Gly Trp Cys Thr Asp Pro Ser Asn Thr Gly Lys Gly Lys Cys Ile Glu
    930                 935                 940                 
Gly Ser Tyr Lys Gly Pro Val Lys Met Pro Ser Gln Ala Pro Thr Gly
945                 950                 955                 960 
Asn Phe Tyr Pro Gln Pro Leu Leu Asn Ser Ser Met Cys Leu Glu Asp
                965                 970                 975     
Ser Arg Tyr Asn Trp Ser Phe Ile His Cys Pro Ala Cys Gln Cys Asn
            980                 985                 990         
Gly His Ser Lys Cys Ile Asn Gln Ser Ile Cys Glu Lys Cys Glu Asn
        995                 1000                1005            
Leu Thr Thr Gly Lys His Cys Glu Thr Cys Ile Ser Gly Phe Tyr Gly
    1010                1015                1020                
Asp Pro Thr Asn Gly Gly Lys Cys Gln Pro Cys Lys Cys Asn Gly His
1025                1030                1035                1040
Ala Ser Leu Cys Asn Thr Asn Thr Gly Lys Cys Phe Cys Thr Thr Lys
                1045                1050                1055    
Gly Val Lys Gly Asp Glu Cys Gln Leu Cys Glu Val Glu Asn Arg Tyr
            1060                1065                1070        
Gln Gly Asn Pro Leu Arg Gly Thr Cys Tyr Tyr Thr Leu Leu Ile Asp
        1075                1080                1085            
Tyr Gln Phe Thr Phe Ser Leu Ser Gln Glu Asp Asp Arg Tyr Tyr Thr
    1090                1095                1100                
Ala Ile Asn Phe Val Ala Thr Pro Asp Glu Gln Asn Arg Asp Leu Asp
1105                1110                1115                1120
Met Phe Ile Asn Ala Ser Lys Asn Phe Asn Leu Asn Ile Thr Trp Ala
                1125                1130                1135    
Ala Ser Phe Ser Ala Gly Thr Gln Ala Gly Glu Glu Met Pro Val Val
            1140                1145                1150        
Ser Lys Thr Asn Ile Lys Glu Tyr Lys Asp Ser Phe Ser Asn Glu Lys
        1155                1160                1165            
Phe Asp Phe Arg Asn His Pro Asn Ile Thr Phe Phe Val Tyr Val Ser
    1170                1175                1180                
Asn Phe Thr Trp Pro Ile Lys Ile Gln Val Gln Thr Glu Gln
1185                1190                1195            


<210> 5497
<211> 1272
<212> PRT
<213> Homo sapiens

<400> 5497
Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr
 1               5                  10                  15      
Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp
            20                  25                  30          
Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg
        35                  40                  45              
Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu
    50                  55                  60                  
Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu
65                  70                  75                  80  
Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala
                85                  90                  95      
Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn
            100                 105                 110         
Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln
        115                 120                 125             
Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe
    130                 135                 140                 
Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp
145                 150                 155                 160 
Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His
                165                 170                 175     
Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp
            180                 185                 190         
Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro
        195                 200                 205             
Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly
    210                 215                 220                 
Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly
225                 230                 235                 240 
Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly
                245                 250                 255     
Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu
            260                 265                 270         
Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr
        275                 280                 285             
Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val
    290                 295                 300                 
Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val
305                 310                 315                 320 
Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn
                325                 330                 335     
Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile
            340                 345                 350         
Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met
        355                 360                 365             
Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg
    370                 375                 380                 
Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr
385                 390                 395                 400 
Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn
                405                 410                 415     
Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val
            420                 425                 430         
Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser
        435                 440                 445             
Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile
    450                 455                 460                 
Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr
465                 470                 475                 480 
Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu
                485                 490                 495     
Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg
            500                 505                 510         
Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr
        515                 520                 525             
Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp
    530                 535                 540                 
Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val
545                 550                 555                 560 
Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp
                565                 570                 575     
Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala
            580                 585                 590         
Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu
        595                 600                 605             
His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser
    610                 615                 620                 
Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile
625                 630                 635                 640 
Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala
                645                 650                 655     
Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser
            660                 665                 670         
Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys
        675                 680                 685             
Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys
    690                 695                 700                 
Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys
705                 710                 715                 720 
His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu
                725                 730                 735     
Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro
            740                 745                 750         
Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp
        755                 760                 765             
Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro
    770                 775                 780                 
Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu
785                 790                 795                 800 
Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys
                805                 810                 815     
Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val
            820                 825                 830         
Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met
        835                 840                 845             
Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val
    850                 855                 860                 
Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu
865                 870                 875                 880 
Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu
                885                 890                 895     
Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro
            900                 905                 910         
Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln
        915                 920                 925             
Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser
    930                 935                 940                 
Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp
945                 950                 955                 960 
Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp
                965                 970                 975     
Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr
            980                 985                 990         
Cys Ser His Cys Leu Glu Gln Pro Gly Cys Gly Trp Cys Thr Asp Pro
        995                 1000                1005            
Ser Asn Thr Gly Lys Gly Lys Cys Ile Glu Gly Ser Tyr Lys Gly Pro
    1010                1015                1020                
Val Lys Met Pro Ser Gln Ala Pro Thr Gly Asn Phe Tyr Pro Gln Pro
1025                1030                1035                1040
Leu Leu Asn Ser Ser Met Cys Leu Glu Asp Ser Arg Tyr Asn Trp Ser
                1045                1050                1055    
Phe Ile His Cys Pro Ala Cys Gln Cys Asn Gly His Ser Lys Cys Ile
            1060                1065                1070        
Asn Gln Ser Ile Cys Glu Lys Cys Glu Asn Leu Thr Thr Gly Lys His
        1075                1080                1085            
Cys Glu Thr Cys Ile Ser Gly Phe Tyr Gly Asp Pro Thr Asn Gly Gly
    1090                1095                1100                
Lys Cys Gln Pro Cys Lys Cys Asn Gly His Ala Ser Leu Cys Asn Thr
1105                1110                1115                1120
Asn Thr Gly Lys Cys Phe Cys Thr Thr Lys Gly Val Lys Gly Asp Glu
                1125                1130                1135    
Cys Gln Leu Cys Glu Val Glu Asn Arg Tyr Gln Gly Asn Pro Leu Arg
            1140                1145                1150        
Gly Thr Cys Tyr Tyr Thr Leu Leu Ile Asp Tyr Gln Phe Thr Phe Ser
        1155                1160                1165            
Leu Ser Gln Glu Asp Asp Arg Tyr Tyr Thr Ala Ile Asn Phe Val Ala
    1170                1175                1180                
Thr Pro Asp Glu Gln Asn Arg Asp Leu Asp Met Phe Ile Asn Ala Ser
1185                1190                1195                1200
Lys Asn Phe Asn Leu Asn Ile Thr Trp Ala Ala Ser Phe Ser Ala Gly
                1205                1210                1215    
Thr Gln Ala Gly Glu Glu Met Pro Val Val Ser Lys Thr Asn Ile Lys
            1220                1225                1230        
Glu Tyr Lys Asp Ser Phe Ser Asn Glu Lys Phe Asp Phe Arg Asn His
        1235                1240                1245            
Pro Asn Ile Thr Phe Phe Val Tyr Val Ser Asn Phe Thr Trp Pro Ile
    1250                1255                1260                
Lys Ile Gln Val Gln Thr Glu Gln
1265                1270        


<210> 5498
<211> 1393
<212> PRT
<213> Homo sapiens

<400> 5498
Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr
 1               5                  10                  15      
Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp
            20                  25                  30          
Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg
        35                  40                  45              
Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu
    50                  55                  60                  
Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu
65                  70                  75                  80  
Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala
                85                  90                  95      
Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn
            100                 105                 110         
Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln
        115                 120                 125             
Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe
    130                 135                 140                 
Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp
145                 150                 155                 160 
Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His
                165                 170                 175     
Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp
            180                 185                 190         
Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro
        195                 200                 205             
Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly
    210                 215                 220                 
Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly
225                 230                 235                 240 
Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly
                245                 250                 255     
Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu
            260                 265                 270         
Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr
        275                 280                 285             
Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val
    290                 295                 300                 
Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val
305                 310                 315                 320 
Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn
                325                 330                 335     
Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile
            340                 345                 350         
Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met
        355                 360                 365             
Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg
    370                 375                 380                 
Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr
385                 390                 395                 400 
Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn
                405                 410                 415     
Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val
            420                 425                 430         
Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser
        435                 440                 445             
Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile
    450                 455                 460                 
Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr
465                 470                 475                 480 
Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu
                485                 490                 495     
Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg
            500                 505                 510         
Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr
        515                 520                 525             
Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp
    530                 535                 540                 
Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val
545                 550                 555                 560 
Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp
                565                 570                 575     
Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala
            580                 585                 590         
Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu
        595                 600                 605             
His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser
    610                 615                 620                 
Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile
625                 630                 635                 640 
Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala
                645                 650                 655     
Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Leu Leu Thr Met Thr Asp
            660                 665                 670         
Val Thr Ser Thr Gln Ile Val Thr Ala Ala Gln Pro Thr Pro Met Thr
        675                 680                 685             
Ala Thr Gly Ala Met Thr Ile Val Ser Pro Gly Thr Thr Ala Ala Gln
    690                 695                 700                 
Lys Ala Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro Met Tyr Tyr Cys
705                 710                 715                 720 
Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp Gln Asn Cys Gln
                725                 730                 735     
Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro Glu Asn Ile Cys
            740                 745                 750         
Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu Lys Ile Thr Thr
        755                 760                 765             
Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys Arg Asn His Asn
    770                 775                 780                 
Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val Glu Phe Val Leu
785                 790                 795                 800 
Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met Ser Lys Leu Thr
                805                 810                 815     
Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val Ser Tyr Trp Cys
            820                 825                 830         
Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu Gln Trp Met Pro
        835                 840                 845             
Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu Ser Glu Pro Ser
    850                 855                 860                 
Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro Leu Asn Gly Ser
865                 870                 875                 880 
Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln Cys Arg Thr Pro
                885                 890                 895     
Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser Gly Ser Ser Glu
            900                 905                 910         
Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp Ser Asn Ala Tyr
        915                 920                 925             
Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp Tyr Thr Met Ser
    930                 935                 940                 
Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr Cys Ser His Cys
945                 950                 955                 960 
Leu Glu Gln Pro Gly Cys Gly Trp Cys Thr Asp Pro Ser Asn Thr Gly
                965                 970                 975     
Lys Gly Lys Cys Ile Glu Gly Ser Tyr Lys Gly Pro Val Lys Met Pro
            980                 985                 990         
Ser Gln Ala Pro Thr Gly Asn Phe Tyr Pro Gln Pro Leu Leu Asn Ser
        995                 1000                1005            
Ser Met Cys Leu Glu Asp Ser Arg Tyr Asn Trp Ser Phe Ile His Cys
    1010                1015                1020                
Pro Ala Cys Gln Cys Asn Gly His Ser Lys Cys Ile Asn Gln Ser Ile
1025                1030                1035                1040
Cys Glu Lys Cys Glu Asn Leu Thr Thr Gly Lys His Cys Glu Thr Cys
                1045                1050                1055    
Ile Ser Gly Phe Tyr Gly Asp Pro Thr Asn Gly Gly Lys Cys Gln Pro
            1060                1065                1070        
Cys Lys Cys Asn Gly His Ala Ser Leu Cys Asn Thr Asn Thr Gly Lys
        1075                1080                1085            
Cys Phe Cys Thr Thr Lys Gly Val Lys Gly Asp Glu Cys Gln Leu Cys
    1090                1095                1100                
Glu Val Glu Asn Arg Tyr Gln Gly Asn Pro Leu Arg Gly Thr Cys Tyr
1105                1110                1115                1120
Tyr Thr Leu Leu Ile Asp Tyr Gln Phe Thr Phe Ser Leu Ser Gln Glu
                1125                1130                1135    
Asp Asp Arg Tyr Tyr Thr Ala Ile Asn Phe Val Ala Thr Pro Asp Glu
            1140                1145                1150        
Gln Asn Arg Asp Leu Asp Met Phe Ile Asn Ala Ser Lys Asn Phe Asn
        1155                1160                1165            
Leu Asn Ile Thr Trp Ala Ala Ser Phe Ser Ala Gly Thr Gln Ala Gly
    1170                1175                1180                
Glu Glu Met Pro Val Val Ser Lys Thr Asn Ile Lys Glu Tyr Lys Asp
1185                1190                1195                1200
Ser Phe Ser Asn Glu Lys Phe Asp Phe Arg Asn His Pro Asn Ile Thr
                1205                1210                1215    
Phe Phe Val Tyr Val Ser Asn Phe Thr Trp Pro Ile Lys Ile Gln Ile
            1220                1225                1230        
Ala Phe Ser Gln His Ser Asn Phe Met Asp Leu Val Gln Phe Phe Val
        1235                1240                1245            
Thr Phe Phe Ser Cys Phe Leu Ser Leu Leu Leu Val Ala Ala Val Val
    1250                1255                1260                
Trp Lys Ile Lys Gln Ser Cys Trp Ala Ser Arg Arg Arg Glu Gln Leu
1265                1270                1275                1280
Leu Arg Glu Met Gln Gln Met Ala Ser Arg Pro Phe Ala Ser Val Asn
                1285                1290                1295    
Val Ala Leu Glu Thr Asp Glu Glu Pro Pro Asp Leu Ile Gly Gly Ser
            1300                1305                1310        
Ile Lys Thr Val Pro Lys Pro Ile Ala Leu Glu Pro Cys Phe Gly Asn
        1315                1320                1325            
Lys Ala Ala Val Leu Ser Val Phe Val Arg Leu Pro Arg Gly Leu Gly
    1330                1335                1340                
Gly Ile Pro Pro Pro Gly Gln Ser Gly Leu Ala Val Ala Ser Ala Leu
1345                1350                1355                1360
Val Asp Ile Ser Gln Gln Met Pro Ile Val Tyr Lys Glu Lys Ser Gly
                1365                1370                1375    
Ala Val Arg Asn Arg Lys Gln Gln Pro Pro Ala Gln Pro Gly Thr Cys
            1380                1385                1390        
Ile
    


<210> 5499
<211> 1429
<212> PRT
<213> Homo sapiens

<400> 5499
Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr
 1               5                  10                  15      
Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp
            20                  25                  30          
Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg
        35                  40                  45              
Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu
    50                  55                  60                  
Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu
65                  70                  75                  80  
Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala
                85                  90                  95      
Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn
            100                 105                 110         
Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln
        115                 120                 125             
Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe
    130                 135                 140                 
Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp
145                 150                 155                 160 
Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His
                165                 170                 175     
Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp
            180                 185                 190         
Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro
        195                 200                 205             
Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly
    210                 215                 220                 
Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly
225                 230                 235                 240 
Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly
                245                 250                 255     
Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu
            260                 265                 270         
Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr
        275                 280                 285             
Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val
    290                 295                 300                 
Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val
305                 310                 315                 320 
Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn
                325                 330                 335     
Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile
            340                 345                 350         
Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met
        355                 360                 365             
Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg
    370                 375                 380                 
Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr
385                 390                 395                 400 
Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn
                405                 410                 415     
Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val
            420                 425                 430         
Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser
        435                 440                 445             
Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile
    450                 455                 460                 
Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr
465                 470                 475                 480 
Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu
                485                 490                 495     
Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg
            500                 505                 510         
Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr
        515                 520                 525             
Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp
    530                 535                 540                 
Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val
545                 550                 555                 560 
Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp
                565                 570                 575     
Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala
            580                 585                 590         
Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu
        595                 600                 605             
His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser
    610                 615                 620                 
Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile
625                 630                 635                 640 
Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala
                645                 650                 655     
Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser
            660                 665                 670         
Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys
        675                 680                 685             
Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys
    690                 695                 700                 
Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys
705                 710                 715                 720 
His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu
                725                 730                 735     
Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro
            740                 745                 750         
Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp
        755                 760                 765             
Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro
    770                 775                 780                 
Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu
785                 790                 795                 800 
Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys
                805                 810                 815     
Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val
            820                 825                 830         
Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met
        835                 840                 845             
Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val
    850                 855                 860                 
Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu
865                 870                 875                 880 
Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu
                885                 890                 895     
Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro
            900                 905                 910         
Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln
        915                 920                 925             
Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser
    930                 935                 940                 
Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp
945                 950                 955                 960 
Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp
                965                 970                 975     
Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr
            980                 985                 990         
Cys Ser His Cys Leu Glu Gln Pro Gly Cys Gly Trp Cys Thr Asp Pro
        995                 1000                1005            
Ser Asn Thr Gly Lys Gly Lys Cys Ile Glu Gly Ser Tyr Lys Gly Pro
    1010                1015                1020                
Val Lys Met Pro Ser Gln Ala Pro Thr Gly Asn Phe Tyr Pro Gln Pro
1025                1030                1035                1040
Leu Leu Asn Ser Ser Met Cys Leu Glu Asp Ser Arg Tyr Asn Trp Ser
                1045                1050                1055    
Phe Ile His Cys Pro Ala Cys Gln Cys Asn Gly His Ser Lys Cys Ile
            1060                1065                1070        
Asn Gln Ser Ile Cys Glu Lys Cys Glu Asn Leu Thr Thr Gly Lys His
        1075                1080                1085            
Cys Glu Thr Cys Ile Ser Gly Phe Tyr Gly Asp Pro Thr Asn Gly Gly
    1090                1095                1100                
Lys Cys Gln Pro Cys Lys Cys Asn Gly His Ala Ser Leu Cys Asn Thr
1105                1110                1115                1120
Asn Thr Gly Lys Cys Phe Cys Thr Thr Lys Gly Val Lys Gly Asp Glu
                1125                1130                1135    
Cys Gln Leu Cys Glu Val Glu Asn Arg Tyr Gln Gly Asn Pro Leu Arg
            1140                1145                1150        
Gly Thr Cys Tyr Tyr Thr Leu Leu Ile Asp Tyr Gln Phe Thr Phe Ser
        1155                1160                1165            
Leu Ser Gln Glu Asp Asp Arg Tyr Tyr Thr Ala Ile Asn Phe Val Ala
    1170                1175                1180                
Thr Pro Asp Glu Gln Asn Arg Asp Leu Asp Met Phe Ile Asn Ala Ser
1185                1190                1195                1200
Lys Asn Phe Asn Leu Asn Ile Thr Trp Ala Ala Ser Phe Ser Ala Gly
                1205                1210                1215    
Thr Gln Ala Gly Glu Glu Met Pro Val Val Ser Lys Thr Asn Ile Lys
            1220                1225                1230        
Glu Tyr Lys Asp Ser Phe Ser Asn Glu Lys Phe Asp Phe Arg Asn His
        1235                1240                1245            
Pro Asn Ile Thr Phe Phe Val Tyr Val Ser Asn Phe Thr Trp Pro Ile
    1250                1255                1260                
Lys Ile Gln Ile Ala Phe Ser Gln His Ser Asn Phe Met Asp Leu Val
1265                1270                1275                1280
Gln Phe Phe Val Thr Phe Phe Ser Cys Phe Leu Ser Leu Leu Leu Val
                1285                1290                1295    
Ala Ala Val Val Trp Lys Ile Lys Gln Ser Cys Trp Ala Ser Arg Arg
            1300                1305                1310        
Arg Glu Gln Leu Leu Arg Glu Met Gln Gln Met Ala Ser Arg Pro Phe
        1315                1320                1325            
Ala Ser Val Asn Val Ala Leu Glu Thr Asp Glu Glu Pro Pro Asp Leu
    1330                1335                1340                
Ile Gly Gly Ser Ile Lys Thr Val Pro Lys Pro Ile Ala Leu Glu Pro
1345                1350                1355                1360
Cys Phe Gly Asn Lys Ala Ala Val Leu Ser Val Phe Val Arg Leu Pro
                1365                1370                1375    
Arg Gly Leu Gly Gly Ile Pro Pro Pro Gly Gln Ser Gly Leu Ala Val
            1380                1385                1390        
Ala Ser Ala Leu Val Asp Ile Ser Gln Gln Met Pro Ile Val Tyr Lys
        1395                1400                1405            
Glu Lys Ser Gly Ala Val Arg Asn Arg Lys Gln Gln Pro Pro Ala Gln
    1410                1415                1420                
Pro Gly Thr Cys Ile
1425                


<210> 5500
<211> 130
<212> PRT
<213> Homo sapiens

<400> 5500
Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val
 1               5                  10                  15      
Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val
            20                  25                  30          
Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln
        35                  40                  45              
Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln
    50                  55                  60                  
Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg
65                  70                  75                  80  
Val Tyr Leu Gln Gly Leu Ile Asp Tyr Tyr Leu Phe Gly Asn Ser Ser
                85                  90                  95      
Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly
            100                 105                 110         
Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys
        115                 120                 125             
Lys Tyr
    130 


<210> 5501
<211> 406
<212> PRT
<213> Homo sapiens

<400> 5501
Met Gln Leu Phe Leu Leu Leu Cys Leu Val Leu Leu Ser Pro Gln Gly
 1               5                  10                  15      
Ala Ser Leu His Arg His His Pro Arg Glu Met Lys Lys Arg Val Glu
            20                  25                  30          
Asp Leu His Val Gly Ala Thr Val Ala Pro Ser Ser Arg Arg Asp Phe
        35                  40                  45              
Thr Phe Asp Leu Tyr Arg Ala Leu Ala Ser Ala Ala Pro Ser Gln Asn
    50                  55                  60                  
Ile Phe Phe Ser Pro Val Ser Ile Ser Met Ser Leu Ala Met Leu Ser
65                  70                  75                  80  
Leu Gly Ala Gly Ser Ser Thr Lys Met Gln Ile Leu Glu Gly Leu Gly
                85                  90                  95      
Leu Asn Leu Gln Lys Ser Ser Glu Lys Glu Leu His Arg Gly Phe Gln
            100                 105                 110         
Gln Leu Leu Gln Glu Leu Asn Gln Pro Arg Asp Gly Phe Gln Leu Ser
        115                 120                 125             
Leu Gly Asn Ala Leu Phe Thr Asp Leu Val Val Asp Leu Gln Asp Thr
    130                 135                 140                 
Phe Val Ser Ala Met Lys Thr Leu Tyr Leu Ala Asp Thr Phe Pro Thr
145                 150                 155                 160 
Asn Phe Arg Asp Ser Ala Gly Ala Met Lys Gln Ile Asn Asp Tyr Val
                165                 170                 175     
Ala Lys Gln Thr Lys Gly Lys Ile Val Asp Leu Leu Lys Asn Leu Asp
            180                 185                 190         
Ser Asn Ala Val Val Ile Met Val Asn Tyr Ile Phe Phe Lys Ala Lys
        195                 200                 205             
Trp Glu Thr Ser Phe Asn His Lys Gly Thr Gln Glu Gln Asp Phe Tyr
    210                 215                 220                 
Val Thr Ser Glu Thr Val Val Arg Val Pro Met Met Ser Arg Glu Asp
225                 230                 235                 240 
Gln Tyr His Tyr Leu Leu Asp Arg Asn Leu Ser Cys Arg Val Val Gly
                245                 250                 255     
Val Pro Tyr Gln Gly Asn Ala Thr Ala Leu Phe Ile Leu Pro Ser Glu
            260                 265                 270         
Gly Lys Met Gln Gln Val Glu Asn Gly Leu Ser Glu Lys Thr Leu Arg
        275                 280                 285             
Lys Trp Leu Lys Met Phe Lys Lys Arg Gln Leu Glu Leu Tyr Leu Pro
    290                 295                 300                 
Lys Phe Ser Ile Glu Gly Ser Tyr Gln Leu Glu Lys Val Leu Pro Ser
305                 310                 315                 320 
Leu Gly Ile Ser Asn Val Phe Thr Ser His Ala Asp Leu Ser Gly Ile
                325                 330                 335     
Ser Asn His Ser Asn Ile Gln Val Ser Glu Met Val His Lys Ala Val
            340                 345                 350         
Val Glu Val Asp Glu Ser Gly Thr Arg Ala Ala Ala Ala Thr Gly Thr
        355                 360                 365             
Ile Phe Thr Phe Arg Ser Ala Arg Leu Asn Ser Gln Arg Leu Val Phe
    370                 375                 380                 
Asn Arg Pro Phe Leu Met Phe Ile Val Asp Asn Asn Ile Leu Phe Leu
385                 390                 395                 400 
Gly Lys Val Asn Arg Pro
                405     


<210> 5502
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5502
Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys
 1               5                  10                  15      
His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly
            20                  25                  30          
Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro
        35                  40                  45              
Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro
    50                  55                  60                  
Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala
65                  70                  75                  80  
Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu
                85                  90                  95      
His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu
            100                 105                 110         
Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp
        115                 120                 125             
Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser
    130                 135                 140                 
Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys
145                 150                 155                 160 
Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu
                165                 170                 175     
Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro
            180                 185                 190         
Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys
        195                 200                 205             
Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg
    210                 215                 220                 
Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu
225                 230                 235                 240 
Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu
                245                 250                 255     
Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met
            260                 265                 270         
Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly
        275                 280                 285             
Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly
    290                 295                 300                 
Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly
305                 310                 315                 320 
Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly
                325                 330                 335     
Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val
            340                 345                 350         
Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr
        355                 360                 365             
Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met
    370                 375                 380                 
Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His
385                 390                 395                 400 
Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu
                405                 410                 415     
Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp
            420                 425                 430         
Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp
        435                 440                 445             
Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly
    450                 455                 460                 
Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met
465                 470                 475                 480 
Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln
                485                 490     


<210> 5503
<211> 655
<212> PRT
<213> Homo sapiens

<400> 5503
Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu
 1               5                  10                  15      
Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly
            20                  25                  30          
Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn
        35                  40                  45              
Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr
    50                  55                  60                  
Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser
65                  70                  75                  80  
Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro
                85                  90                  95      
Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe
            100                 105                 110         
Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala
        115                 120                 125             
His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala
    130                 135                 140                 
Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala
145                 150                 155                 160 
Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser
                165                 170                 175     
Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe
            180                 185                 190         
Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr
        195                 200                 205             
Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His
    210                 215                 220                 
Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr
225                 230                 235                 240 
Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys
                245                 250                 255     
His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly
            260                 265                 270         
Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu
        275                 280                 285             
Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly
    290                 295                 300                 
Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His
305                 310                 315                 320 
Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala
                325                 330                 335     
Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val
            340                 345                 350         
Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Glu
        355                 360                 365             
Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu Pro
    370                 375                 380                 
Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys Lys
385                 390                 395                 400 
Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu Pro
                405                 410                 415     
Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe Cys
            420                 425                 430         
Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His Cys
        435                 440                 445             
Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly Gln
    450                 455                 460                 
His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile Glu
465                 470                 475                 480 
Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His
                485                 490                 495     
Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala Thr
            500                 505                 510         
Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser Thr
        515                 520                 525             
Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu Asp
    530                 535                 540                 
Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val Pro
545                 550                 555                 560 
Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala Asp
                565                 570                 575     
Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser Asp
            580                 585                 590         
Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn Gly
        595                 600                 605             
Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly Arg
    610                 615                 620                 
Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp Trp
625                 630                 635                 640 
Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser
                645                 650                 655 


<210> 5504
<211> 881
<212> PRT
<213> Homo sapiens

<400> 5504
Arg Glu Arg Gln Arg Gly Arg Gln Pro Ala Gly Leu Phe Leu Leu Leu
 1               5                  10                  15      
Lys Thr Tyr Pro Ala Leu Thr Glu Glu Ile Phe Leu Leu Ser Ser Ala
            20                  25                  30          
Leu Asn Val Phe Pro Asn Met Lys Val Ile Ser Leu Phe Ile Leu Val
        35                  40                  45              
Gly Phe Ile Gly Glu Phe Gln Ser Phe Ser Ser Ala Ser Ser Pro Val
    50                  55                  60                  
Asn Cys Gln Trp Asp Phe Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys
65                  70                  75                  80  
Thr Lys Thr Gln Thr Arg Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr
                85                  90                  95      
Gly Gly Gln Pro Cys Val Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu
            100                 105                 110         
Pro Thr Arg Gly Cys Pro Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg
        115                 120                 125             
Cys Phe Ser Gly Gln Cys Ile Ser Lys Ser Leu Val Cys Asn Gly Asp
    130                 135                 140                 
Ser Asp Cys Asp Glu Asp Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser
145                 150                 155                 160 
Glu Arg Arg Pro Ser Cys Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu
                165                 170                 175     
Leu Thr Gly Asn Gly Tyr Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg
            180                 185                 190         
Val Ile Asn Thr Lys Ser Phe Gly Gly Gln Cys Arg Lys Val Phe Ser
        195                 200                 205             
Gly Asp Gly Lys Asp Phe Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr
    210                 215                 220                 
Thr Phe Gln Val Lys Ile Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn
225                 230                 235                 240 
Ser Thr Trp Ser Tyr Val Lys His Thr Ser Thr Glu His Thr Ser Ser
                245                 250                 255     
Ser Arg Lys Arg Ser Phe Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser
            260                 265                 270         
Tyr Thr Ser His Thr Asn Glu Ile His Lys Gly Lys Ser Tyr Gln Leu
        275                 280                 285             
Leu Val Val Glu Asn Thr Val Glu Val Ala Gln Phe Ile Asn Asn Asn
    290                 295                 300                 
Pro Glu Phe Leu Gln Leu Ala Glu Pro Phe Trp Lys Glu Leu Ser His
305                 310                 315                 320 
Leu Pro Ser Leu Tyr Asp Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln
                325                 330                 335     
Tyr Gly Thr His Tyr Leu Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg
            340                 345                 350         
Val Leu Phe Tyr Val Asp Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn
        355                 360                 365             
Ser Val Glu Glu Lys Lys Cys Lys Ser Ser Gly Trp His Phe Val Val
    370                 375                 380                 
Lys Phe Ser Ser His Gly Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala
385                 390                 395                 400 
Ala Ser Gly Thr Gln Asn Asn Val Leu Arg Gly Glu Pro Phe Ile Arg
                405                 410                 415     
Gly Gly Gly Ala Gly Phe Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp
            420                 425                 430         
Asn Pro Ala Gly Asn Lys Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val
        435                 440                 445             
Thr Asn Leu Pro Gln Val Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu
    450                 455                 460                 
Leu Val Lys Glu Val Pro Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys
465                 470                 475                 480 
Trp Ala Leu Glu Glu Tyr Leu Asp Glu Phe Asp Pro Cys His Cys Arg
                485                 490                 495     
Pro Cys Gln Asn Gly Gly Leu Ala Thr Val Glu Gly Thr His Cys Leu
            500                 505                 510         
Cys His Cys Lys Pro Tyr Thr Phe Gly Ala Ala Cys Glu Gln Gly Val
        515                 520                 525             
Leu Val Gly Asn Gln Ala Gly Gly Val Asp Gly Gly Trp Ser Cys Trp
    530                 535                 540                 
Ser Ser Trp Ser Pro Cys Val Gln Gly Lys Lys Thr Arg Ser Arg Glu
545                 550                 555                 560 
Cys Asn Asn Pro Pro Pro Ser Gly Gly Gly Arg Ser Cys Val Gly Glu
                565                 570                 575     
Thr Thr Glu Ser Thr Gln Cys Glu Asp Glu Glu Leu Glu His Leu Arg
            580                 585                 590         
Leu Leu Glu Pro His Cys Phe Pro Leu Ser Leu Val Pro Thr Glu Phe
        595                 600                 605             
Cys Pro Ser Pro Pro Ala Leu Lys Asp Gly Phe Val Gln Asp Glu Gly
    610                 615                 620                 
Thr Met Phe Pro Val Gly Lys Asn Val Val Tyr Thr Cys Asn Glu Gly
625                 630                 635                 640 
Tyr Ser Leu Ile Gly Asn Pro Val Ala Arg Cys Gly Glu Asp Leu Arg
                645                 650                 655     
Trp Leu Val Gly Glu Met His Cys Gln Lys Ile Ala Cys Val Leu Pro
            660                 665                 670         
Val Leu Met Asp Gly Ile Gln Ser His Pro Gln Lys Pro Phe Tyr Thr
        675                 680                 685             
Val Gly Glu Lys Val Thr Val Ser Cys Ser Gly Gly Met Ser Leu Glu
    690                 695                 700                 
Gly Pro Ser Ala Phe Leu Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu
705                 710                 715                 720 
Met Lys Asn Ala Arg Cys Val Gln Lys Glu Asn Pro Leu Thr Gln Ala
                725                 730                 735     
Val Pro Lys Cys Gln Arg Trp Glu Lys Leu Gln Asn Ser Arg Cys Val
            740                 745                 750         
Cys Lys Met Pro Tyr Glu Cys Gly Pro Ser Leu Asp Val Cys Ala Gln
        755                 760                 765             
Asp Glu Arg Ser Lys Arg Ile Leu Pro Leu Thr Val Cys Lys Met His
    770                 775                 780                 
Val Leu His Cys Gln Gly Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser
785                 790                 795                 800 
Cys Thr Leu Pro Ala Ser Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu
                805                 810                 815     
Trp Gly Lys Cys Asp Ala Glu Ser Ser Lys Cys Val Cys Arg Glu Ala
            820                 825                 830         
Ser Glu Cys Glu Glu Glu Gly Phe Ser Ile Cys Val Glu Val Asn Gly
        835                 840                 845             
Lys Glu Gln Thr Met Ser Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg
    850                 855                 860                 
Gly Gln Ser Ile Ser Val Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr
865                 870                 875                 880 
Gln
    


<210> 5505
<211> 190
<212> PRT
<213> Homo sapiens

<400> 5505
Met Ala Thr His His Thr Leu Trp Met Gly Leu Ala Leu Leu Gly Val
 1               5                  10                  15      
Leu Gly Asp Leu Gln Ala Ala Pro Glu Ala Gln Val Ser Val Gln Pro
            20                  25                  30          
Asn Phe Gln Gln Asp Lys Phe Leu Gly Arg Trp Phe Ser Ala Gly Leu
        35                  40                  45              
Ala Ser Asn Ser Ser Trp Leu Arg Glu Lys Lys Ala Ala Leu Ser Met
    50                  55                  60                  
Cys Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly Leu Asn Leu Thr
65                  70                  75                  80  
Ser Thr Phe Leu Arg Lys Asn Gln Cys Glu Thr Arg Thr Met Leu Leu
                85                  90                  95      
Gln Pro Ala Gly Ser Leu Gly Ser Tyr Ser Tyr Arg Ser Pro His Trp
            100                 105                 110         
Gly Ser Thr Tyr Ser Val Ser Val Val Glu Thr Asp Tyr Asp Gln Tyr
        115                 120                 125             
Ala Leu Leu Tyr Ser Gln Gly Ser Lys Gly Pro Gly Glu Asp Phe Arg
    130                 135                 140                 
Met Ala Thr Leu Tyr Ser Arg Thr Gln Thr Pro Arg Ala Glu Leu Lys
145                 150                 155                 160 
Glu Lys Phe Thr Ala Phe Cys Lys Ala Gln Gly Phe Thr Glu Asp Thr
                165                 170                 175     
Ile Val Phe Leu Pro Gln Thr Asp Lys Cys Met Thr Glu Gln
            180                 185                 190 


<210> 5506
<211> 885
<212> PRT
<213> Homo sapiens

<400> 5506
Met Val Ala Leu Ser His Leu Gly Ser Ala Leu Gln Leu Gly Ser Leu
 1               5                  10                  15      
Cys Phe Pro Arg Ser Pro Phe Arg Leu Leu Gly Lys Arg Ser Leu Pro
            20                  25                  30          
Glu Gly Val Ala Asn Gly Ile Glu Val Tyr Ser Thr Lys Ile Asn Ser
        35                  40                  45              
Lys Val Thr Ser Arg Phe Ala His Asn Val Val Thr Met Arg Ala Val
    50                  55                  60                  
Asn Arg Ala Asp Thr Ala Lys Glu Val Ser Phe Asp Val Glu Leu Pro
65                  70                  75                  80  
Lys Thr Ala Phe Ile Thr Asn Phe Thr Leu Thr Ile Asp Gly Val Thr
                85                  90                  95      
Tyr Pro Gly Asn Val Lys Glu Lys Glu Val Ala Lys Lys Gln Tyr Glu
            100                 105                 110         
Lys Ala Val Ser Gln Gly Lys Thr Ala Gly Leu Val Lys Ala Ser Gly
        115                 120                 125             
Arg Lys Leu Glu Lys Phe Thr Val Ser Val Asn Val Ala Ala Gly Ser
    130                 135                 140                 
Lys Val Thr Phe Glu Leu Thr Tyr Glu Glu Leu Leu Lys Arg His Lys
145                 150                 155                 160 
Gly Lys Tyr Glu Met Tyr Leu Lys Val Gln Pro Lys Gln Leu Val Lys
                165                 170                 175     
His Phe Glu Ile Glu Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Met
            180                 185                 190         
Leu Asp Ala Glu Ala Ser Phe Ile Thr Asn Asp Leu Leu Gly Ser Ala
        195                 200                 205             
Leu Thr Lys Ser Phe Ser Gly Lys Lys Gly His Val Ser Phe Lys Pro
    210                 215                 220                 
Ser Leu Asp Gln Gln Arg Ser Cys Pro Thr Cys Thr Asp Ser Leu Leu
225                 230                 235                 240 
Asn Gly Asp Phe Thr Ile Thr Tyr Asp Val Asn Arg Glu Ser Pro Gly
                245                 250                 255     
Asn Val Gln Ile Val Asn Gly Tyr Phe Val His Phe Phe Ala Pro Gln
            260                 265                 270         
Gly Leu Pro Val Val Pro Lys Asn Val Ala Phe Val Ile Asp Ile Ser
        275                 280                 285             
Gly Ser Met Ala Gly Arg Lys Leu Glu Gln Thr Lys Glu Ala Leu Leu
    290                 295                 300                 
Arg Ile Leu Glu Asp Met Lys Glu Glu Asp Tyr Leu Asn Phe Ile Leu
305                 310                 315                 320 
Phe Ser Gly Asp Val Ser Thr Trp Lys Glu His Leu Val Gln Ala Thr
                325                 330                 335     
Pro Glu Asn Leu Gln Glu Ala Arg Thr Phe Val Lys Ser Met Glu Asp
            340                 345                 350         
Lys Gly Met Thr Asn Ile Asn Asp Gly Leu Leu Arg Gly Ile Ser Met
        355                 360                 365             
Leu Asn Lys Ala Arg Glu Glu His Arg Ile Pro Glu Arg Ser Thr Ser
    370                 375                 380                 
Ile Val Ile Met Leu Thr Asp Gly Asp Ala Asn Val Gly Glu Ser Arg
385                 390                 395                 400 
Pro Glu Lys Ile Gln Glu Asn Val Arg Asn Ala Ile Gly Gly Lys Phe
                405                 410                 415     
Pro Leu Tyr Asn Leu Gly Phe Gly Asn Asn Leu Asn Tyr Asn Phe Leu
            420                 425                 430         
Glu Asn Met Ala Leu Glu Asn His Gly Phe Ala Arg Arg Ile Tyr Glu
        435                 440                 445             
Asp Ser Asp Ala Asp Leu Gln Leu Gln Gly Phe Tyr Glu Glu Val Ala
    450                 455                 460                 
Asn Pro Leu Leu Thr Gly Val Glu Met Glu Tyr Pro Glu Asn Ala Ile
465                 470                 475                 480 
Leu Asp Leu Thr Gln Asn Thr Tyr Gln His Phe Tyr Asp Gly Ser Glu
                485                 490                 495     
Ile Val Val Ala Gly Arg Leu Val Asp Glu Asp Met Asn Ser Phe Lys
            500                 505                 510         
Ala Asp Val Lys Gly His Gly Ala Thr Asn Asp Leu Thr Phe Thr Glu
        515                 520                 525             
Glu Val Asp Met Lys Glu Met Glu Lys Ala Leu Gln Glu Arg Asp Tyr
    530                 535                 540                 
Ile Phe Gly Asn Tyr Ile Glu Arg Leu Trp Ala Tyr Leu Thr Ile Glu
545                 550                 555                 560 
Gln Leu Leu Glu Lys Arg Lys Asn Ala His Gly Glu Glu Lys Glu Asn
                565                 570                 575     
Leu Thr Ala Arg Ala Leu Asp Leu Ser Leu Lys Tyr His Phe Val Thr
            580                 585                 590         
Pro Leu Thr Ser Met Val Val Thr Lys Pro Glu Asp Asn Glu Asp Glu
        595                 600                 605             
Arg Ala Ile Ala Asp Lys Pro Gly Glu Asp Ala Glu Ala Thr Pro Val
    610                 615                 620                 
Ser Pro Ala Met Ser Tyr Leu Thr Ser Tyr Gln Pro Pro Gln Asn Pro
625                 630                 635                 640 
Tyr Tyr Tyr Val Asp Gly Asp Pro His Phe Ile Ile Gln Ile Pro Glu
                645                 650                 655     
Lys Asp Asp Ala Leu Cys Phe Asn Ile Asp Glu Ala Pro Gly Thr Val
            660                 665                 670         
Leu Arg Leu Ile Gln Asp Ala Val Thr Gly Leu Thr Val Asn Gly Gln
        675                 680                 685             
Ile Thr Gly Asp Lys Arg Gly Ser Pro Asp Ser Lys Thr Arg Lys Thr
    690                 695                 700                 
Tyr Phe Gly Lys Leu Gly Ile Arg Asn Ala Gln Met Asp Phe Gln Val
705                 710                 715                 720 
Glu Val Thr Thr Glu Lys Ile Thr Cys Gly Thr Gly Arg Ala Ser Thr
                725                 730                 735     
Phe Ser Trp Leu Asp Thr Val Thr Val Thr Gln Asp Gly Leu Ser Met
            740                 745                 750         
Met Ile Asn Arg Lys Asn Met Val Val Ser Phe Gly Asp Gly Val Thr
        755                 760                 765             
Phe Val Val Val Leu His Gln Val Trp Lys Lys His Pro Val His Arg
    770                 775                 780                 
Asp Phe Leu Gly Phe Tyr Val Val Asp Ser His Arg Met Ser Ala Gln
785                 790                 795                 800 
Thr His Gly Leu Leu Gly Gln Phe Phe Gln Pro Phe Asp Phe Lys Val
                805                 810                 815     
Ser Asp Ile Arg Pro Gly Ser Asp Pro Thr Lys Pro Asp Ala Thr Leu
            820                 825                 830         
Val Val Lys Asn His Gln Leu Ile Val Thr Arg Gly Ser Gln Lys Asp
        835                 840                 845             
Tyr Arg Lys Asp Ala Ser Ile Gly Thr Lys Val Val Cys Trp Phe Val
    850                 855                 860                 
His Asn Asn Gly Glu Gly Leu Ile Asp Gly Val His Thr Asp Tyr Ile
865                 870                 875                 880 
Val Pro Asn Leu Phe
                885 


<210> 5507
<211> 1228
<212> PRT
<213> Homo sapiens

<400> 5507
Met Lys Gly Ala Arg Leu Phe Val Leu Leu Ser Ser Leu Trp Ser Gly
 1               5                  10                  15      
Gly Ile Gly Leu Asn Asn Ser Lys His Ser Trp Thr Ile Pro Glu Asp
            20                  25                  30          
Gly Asn Ser Gln Lys Thr Met Pro Ser Ala Ser Val Pro Pro Asn Lys
        35                  40                  45              
Ile Gln Ser Leu Gln Ile Leu Pro Thr Thr Arg Val Met Ser Ala Glu
    50                  55                  60                  
Ile Ala Thr Thr Pro Glu Ala Arg Thr Ser Glu Asp Ser Leu Leu Lys
65                  70                  75                  80  
Ser Thr Leu Pro Pro Ser Glu Thr Ser Ala Pro Ala Glu Gly Val Arg
                85                  90                  95      
Asn Gln Thr Leu Thr Ser Thr Glu Lys Ala Glu Gly Val Val Lys Leu
            100                 105                 110         
Gln Asn Leu Thr Leu Pro Thr Asn Ala Ser Ile Lys Phe Asn Pro Gly
        115                 120                 125             
Ala Glu Ser Val Val Leu Ser Asn Ser Thr Leu Lys Phe Leu Gln Ser
    130                 135                 140                 
Phe Ala Arg Lys Ser Asn Glu Gln Ala Thr Ser Leu Asn Thr Val Gly
145                 150                 155                 160 
Gly Thr Gly Gly Ile Gly Gly Val Gly Gly Thr Gly Gly Val Gly Asn
                165                 170                 175     
Arg Ala Pro Arg Glu Thr Tyr Leu Ser Arg Gly Asp Ser Ser Ser Ser
            180                 185                 190         
Gln Arg Thr Asp Tyr Gln Lys Ser Asn Phe Glu Thr Thr Arg Gly Lys
        195                 200                 205             
Asn Trp Cys Ala Tyr Val His Thr Arg Leu Ser Pro Thr Val Thr Leu
    210                 215                 220                 
Asp Asn Gln Val Thr Tyr Val Pro Gly Gly Lys Gly Pro Cys Gly Trp
225                 230                 235                 240 
Thr Gly Gly Ser Cys Pro Gln Arg Ser Gln Lys Ile Ser Asn Pro Val
                245                 250                 255     
Tyr Arg Met Gln His Lys Ile Val Thr Ser Leu Asp Trp Arg Cys Cys
            260                 265                 270         
Pro Gly Tyr Ser Gly Pro Lys Cys Gln Leu Arg Ala Gln Glu Gln Gln
        275                 280                 285             
Ser Leu Ile His Thr Asn Gln Ala Glu Ser His Thr Ala Val Gly Arg
    290                 295                 300                 
Gly Val Ala Glu Gln Gln Gln Gln Gln Gly Cys Gly Asp Pro Glu Val
305                 310                 315                 320 
Met Gln Lys Met Thr Asp Gln Val Asn Tyr Gln Ala Met Lys Leu Thr
                325                 330                 335     
Leu Leu Gln Lys Lys Ile Asp Asn Ile Ser Leu Thr Val Asn Asp Val
            340                 345                 350         
Arg Asn Thr Tyr Ser Ser Leu Glu Gly Lys Val Ser Glu Asp Lys Ser
        355                 360                 365             
Arg Glu Phe Gln Ser Leu Leu Lys Gly Leu Lys Ser Lys Ser Ile Asn
    370                 375                 380                 
Val Leu Ile Arg Asp Ile Val Arg Glu Gln Phe Lys Ile Phe Gln Asn
385                 390                 395                 400 
Asp Met Gln Glu Thr Val Ala Gln Leu Phe Lys Thr Val Ser Ser Leu
                405                 410                 415     
Ser Glu Asp Leu Glu Ser Thr Arg Gln Ile Ile Gln Lys Val Asn Glu
            420                 425                 430         
Ser Val Val Ser Ile Ala Ala Gln Gln Lys Phe Val Leu Val Gln Glu
        435                 440                 445             
Asn Arg Pro Thr Leu Thr Asp Ile Val Glu Leu Arg Asn His Ile Val
    450                 455                 460                 
Asn Val Arg Gln Glu Met Thr Leu Thr Cys Glu Lys Pro Ile Lys Glu
465                 470                 475                 480 
Leu Glu Val Lys Gln Thr His Leu Glu Gly Ala Leu Glu Gln Glu His
                485                 490                 495     
Ser Arg Ser Ile Leu Tyr Tyr Glu Ser Leu Asn Lys Thr Leu Ser Lys
            500                 505                 510         
Leu Lys Glu Val His Glu Gln Leu Leu Ser Thr Glu Gln Val Ser Asp
        515                 520                 525             
Gln Lys Asn Ala Pro Ala Ala Glu Ser Val Ser Asn Asn Val Thr Glu
    530                 535                 540                 
Tyr Met Ser Thr Leu His Glu Asn Ile Lys Lys Gln Ser Leu Met Met
545                 550                 555                 560 
Leu Gln Met Phe Glu Asp Leu His Ile Gln Glu Ser Lys Ile Asn Asn
                565                 570                 575     
Leu Thr Val Ser Leu Glu Met Glu Lys Glu Ser Leu Arg Gly Glu Cys
            580                 585                 590         
Glu Asp Met Leu Ser Lys Cys Arg Asn Asp Phe Lys Phe Gln Leu Lys
        595                 600                 605             
Asp Thr Glu Glu Asn Leu His Val Leu Asn Gln Thr Leu Ala Glu Val
    610                 615                 620                 
Leu Phe Pro Met Asp Asn Lys Met Asp Lys Met Ser Glu Gln Leu Asn
625                 630                 635                 640 
Asp Leu Thr Tyr Asp Met Glu Ile Leu Gln Pro Leu Leu Glu Gln Gly
                645                 650                 655     
Ala Ser Leu Arg Gln Thr Met Thr Tyr Glu Gln Pro Lys Glu Ala Ile
            660                 665                 670         
Val Ile Arg Lys Lys Ile Glu Asn Leu Thr Ser Ala Val Asn Ser Leu
        675                 680                 685             
Asn Phe Ile Ile Lys Glu Leu Thr Lys Arg His Asn Leu Leu Arg Asn
    690                 695                 700                 
Glu Val Gln Gly Arg Asp Asp Ala Leu Glu Arg Arg Ile Asn Glu Tyr
705                 710                 715                 720 
Ala Leu Glu Met Glu Asp Gly Leu Asn Lys Thr Met Thr Ile Ile Asn
                725                 730                 735     
Asn Ala Ile Asp Phe Ile Gln Asp Asn Tyr Ala Leu Lys Glu Thr Leu
            740                 745                 750         
Ser Thr Ile Lys Asp Asn Ser Glu Ile His His Lys Cys Thr Ser Asp
        755                 760                 765             
Met Glu Thr Ile Leu Thr Phe Ile Pro Gln Phe His Arg Leu Asn Asp
    770                 775                 780                 
Ser Ile Gln Thr Leu Val Asn Asp Asn Gln Arg Tyr Asn Phe Val Leu
785                 790                 795                 800 
Gln Val Ala Lys Thr Leu Ala Gly Ile Pro Arg Asp Glu Lys Leu Asn
                805                 810                 815     
Gln Ser Asn Phe Gln Lys Met Tyr Gln Met Phe Asn Glu Thr Thr Ser
            820                 825                 830         
Gln Val Arg Lys Tyr Gln Gln Asn Met Ser His Leu Glu Glu Lys Leu
        835                 840                 845             
Leu Leu Thr Thr Lys Ile Ser Lys Asn Phe Glu Thr Arg Leu Gln Asp
    850                 855                 860                 
Ile Glu Ser Lys Val Thr Gln Thr Leu Ile Pro Tyr Tyr Ile Ser Val
865                 870                 875                 880 
Lys Lys Gly Ser Val Val Thr Asn Glu Arg Asp Gln Ala Leu Gln Leu
                885                 890                 895     
Gln Val Leu Asn Ser Arg Phe Lys Ala Leu Glu Ala Lys Ser Ile His
            900                 905                 910         
Leu Ser Ile Asn Phe Phe Ser Leu Asn Lys Thr Leu His Glu Val Leu
        915                 920                 925             
Thr Met Cys His Asn Ala Ser Thr Ser Val Ser Glu Leu Asn Ala Thr
    930                 935                 940                 
Ile Pro Lys Trp Ile Lys His Ser Leu Pro Asp Ile Gln Leu Leu Gln
945                 950                 955                 960 
Lys Gly Leu Thr Glu Phe Val Glu Pro Ile Ile Gln Ile Lys Thr Gln
                965                 970                 975     
Ala Ala Leu Ser Asn Ser Thr Cys Cys Ile Asp Arg Ser Leu Pro Gly
            980                 985                 990         
Ser Leu Ala Asn Val Val Lys Ser Gln Lys Gln Val Lys Ser Leu Pro
        995                 1000                1005            
Lys Lys Ile Asn Ala Leu Lys Lys Pro Thr Val Asn Leu Thr Thr Val
    1010                1015                1020                
Leu Ile Gly Arg Thr Gln Arg Asn Thr Asp Asn Ile Ile Tyr Pro Glu
1025                1030                1035                1040
Glu Tyr Ser Ser Cys Ser Arg His Pro Cys Gln Asn Gly Gly Thr Cys
                1045                1050                1055    
Ile Asn Gly Arg Thr Ser Phe Thr Cys Ala Cys Arg His Pro Phe Thr
            1060                1065                1070        
Gly Asp Asn Cys Thr Ile Lys Leu Val Glu Glu Asn Ala Leu Ala Pro
        1075                1080                1085            
Asp Phe Ser Lys Gly Ser Tyr Arg Tyr Ala Pro Met Val Ala Phe Phe
    1090                1095                1100                
Ala Ser His Thr Tyr Gly Met Thr Ile Pro Gly Pro Ile Leu Phe Asn
1105                1110                1115                1120
Asn Leu Asp Val Asn Tyr Gly Ala Ser Tyr Thr Pro Arg Thr Gly Lys
                1125                1130                1135    
Phe Arg Ile Pro Tyr Leu Gly Val Tyr Val Phe Lys Tyr Thr Ile Glu
            1140                1145                1150        
Ser Phe Ser Ala His Ile Ser Gly Phe Leu Val Val Asp Gly Ile Asp
        1155                1160                1165            
Lys Leu Ala Phe Glu Ser Glu Asn Ile Asn Ser Glu Ile His Cys Asp
    1170                1175                1180                
Arg Val Leu Thr Gly Asp Ala Leu Leu Glu Leu Asn Tyr Gly Gln Glu
1185                1190                1195                1200
Val Trp Leu Arg Leu Ala Lys Gly Thr Ile Pro Ala Lys Phe Pro Pro
                1205                1210                1215    
Val Thr Thr Phe Ser Gly Tyr Leu Leu Tyr Arg Thr
            1220                1225            


<210> 5508
<211> 385
<212> PRT
<213> Homo sapiens

<400> 5508
Met Gly Cys Arg Arg Thr Arg Glu Gly Pro Ser Lys Ala Met Ile Phe
 1               5                  10                  15      
Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn Ile Phe Lys
            20                  25                  30          
Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala His His Gly
        35                  40                  45              
Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met Asn Trp Gln
    50                  55                  60                  
Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu Val Ala Ile
65                  70                  75                  80  
Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu Pro Phe Ser
                85                  90                  95      
Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly Ile Trp Thr
            100                 105                 110         
Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu Asn Trp Gly
        115                 120                 125             
Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys Val Glu Ile
    130                 135                 140                 
Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp Asp Ala Cys
145                 150                 155                 160 
His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys Gln Pro Trp
                165                 170                 175     
Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn Asn Tyr Thr
            180                 185                 190         
Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln Phe Val Ile
        195                 200                 205             
Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met Asp Cys Thr
    210                 215                 220                 
His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala Phe Ser Cys
225                 230                 235                 240 
Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr Cys Gly Pro
                245                 250                 255     
Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val Ile Gln Cys
            260                 265                 270         
Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys Ser His Pro
        275                 280                 285             
Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile Cys Ser Glu
    290                 295                 300                 
Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu Ser Ser Gly
305                 310                 315                 320 
Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp Lys Ser Phe
                325                 330                 335     
Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile Pro Val Ala
            340                 345                 350         
Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile Trp Leu Ala
        355                 360                 365             
Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met Asn Asp Pro
    370                 375                 380                 
Tyr
385 


<210> 5509
<211> 2224
<212> PRT
<213> Homo sapiens

<400> 5509
Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr
 1               5                  10                  15      
Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg
            20                  25                  30          
Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu
        35                  40                  45              
Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile
    50                  55                  60                  
Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser
65                  70                  75                  80  
Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp
                85                  90                  95      
Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile
            100                 105                 110         
His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr
        115                 120                 125             
Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro
    130                 135                 140                 
Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro
145                 150                 155                 160 
Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu
                165                 170                 175     
Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile
            180                 185                 190         
Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp
        195                 200                 205             
Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp
    210                 215                 220                 
Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly
225                 230                 235                 240 
Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His
                245                 250                 255     
Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn
            260                 265                 270         
Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu
        275                 280                 285             
Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly
    290                 295                 300                 
Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met
305                 310                 315                 320 
Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu
                325                 330                 335     
Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr
            340                 345                 350         
Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro
        355                 360                 365             
Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser
    370                 375                 380                 
Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu
385                 390                 395                 400 
Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp
                405                 410                 415     
Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys
            420                 425                 430         
Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His
        435                 440                 445             
Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr
    450                 455                 460                 
Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr
465                 470                 475                 480 
Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn
                485                 490                 495     
Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met
            500                 505                 510         
Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser
        515                 520                 525             
Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln
    530                 535                 540                 
Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu
545                 550                 555                 560 
Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp
                565                 570                 575     
Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr Ile Asn Gly Tyr
            580                 585                 590         
Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe Asp Asp Thr Val
        595                 600                 605             
Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu Ile Leu Thr Ile
    610                 615                 620                 
His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg His Glu Asp Thr
625                 630                 635                 640 
Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr Val Thr Met Asp
                645                 650                 655     
Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser
            660                 665                 670         
Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys Ile Pro Asp Asp
        675                 680                 685             
Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu Ser Thr Val Met
    690                 695                 700                 
Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu Asp Glu Glu Ser
705                 710                 715                 720 
Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala Ala Leu Gly Ile
                725                 730                 735     
Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu Glu Glu Phe Asn
            740                 745                 750         
Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe Val Ser Ser Asn
        755                 760                 765             
Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro Ser Asn Ile Ser
    770                 775                 780                 
Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys Ala Pro Ser His
785                 790                 795                 800 
Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His Leu Ile Gly Lys
                805                 810                 815     
Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr Ser
            820                 825                 830         
Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile Arg
        835                 840                 845             
Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln Glu His Ala Lys
    850                 855                 860                 
His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala Lys His Arg Phe
865                 870                 875                 880 
Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg His Leu Ser Gln
                885                 890                 895     
Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu Asp Leu Pro Ser
            900                 905                 910         
Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp Lys Asp Pro Pro
        915                 920                 925             
Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser Lys Ile Leu Val
    930                 935                 940                 
Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr Glu Ile Ile Gln
945                 950                 955                 960 
Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu Ile Ser Pro Gln
                965                 970                 975     
Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu Ala Asn Lys Pro
            980                 985                 990         
Gly Lys Gln Ser Gly His Pro Lys Phe Pro Arg Val Arg His Lys Ser
        995                 1000                1005            
Leu Gln Val Arg Gln Asp Gly Gly Lys Ser Arg Leu Lys Lys Ser Gln
    1010                1015                1020                
Phe Leu Ile Lys Thr Arg Lys Lys Lys Lys Glu Lys His Thr His His
1025                1030                1035                1040
Ala Pro Leu Ser Pro Arg Thr Phe His Pro Leu Arg Ser Glu Ala Tyr
                1045                1050                1055    
Asn Thr Phe Ser Glu Arg Arg Leu Lys His Ser Leu Val Leu His Lys
            1060                1065                1070        
Ser Asn Glu Thr Ser Leu Pro Thr Asp Leu Asn Gln Thr Leu Pro Ser
        1075                1080                1085            
Met Asp Phe Gly Trp Ile Ala Ser Leu Pro Asp His Asn Gln Asn Ser
    1090                1095                1100                
Ser Asn Asp Thr Gly Gln Ala Ser Cys Pro Pro Gly Leu Tyr Gln Thr
1105                1110                1115                1120
Val Pro Pro Glu Glu His Tyr Gln Thr Phe Pro Ile Gln Asp Pro Asp
                1125                1130                1135    
Gln Met His Ser Thr Ser Asp Pro Ser His Arg Ser Ser Ser Pro Glu
            1140                1145                1150        
Leu Ser Glu Met Leu Glu Tyr Asp Arg Ser His Lys Ser Phe Pro Thr
        1155                1160                1165            
Asp Ile Ser Gln Met Ser Pro Ser Ser Glu His Glu Val Trp Gln Thr
    1170                1175                1180                
Val Ile Ser Pro Asp Leu Ser Gln Val Thr Leu Ser Pro Glu Leu Ser
1185                1190                1195                1200
Gln Thr Asn Leu Ser Pro Asp Leu Ser His Thr Thr Leu Ser Pro Glu
                1205                1210                1215    
Leu Ile Gln Arg Asn Leu Ser Pro Ala Leu Gly Gln Met Pro Ile Ser
            1220                1225                1230        
Pro Asp Leu Ser His Thr Thr Leu Ser Pro Asp Leu Ser His Thr Thr
        1235                1240                1245            
Leu Ser Leu Asp Leu Ser Gln Thr Asn Leu Ser Pro Glu Leu Ser Gln
    1250                1255                1260                
Thr Asn Leu Ser Pro Ala Leu Gly Gln Met Pro Leu Ser Pro Asp Leu
1265                1270                1275                1280
Ser His Thr Thr Leu Ser Leu Asp Phe Ser Gln Thr Asn Leu Ser Pro
                1285                1290                1295    
Glu Leu Ser His Met Thr Leu Ser Pro Glu Leu Ser Gln Thr Asn Leu
            1300                1305                1310        
Ser Pro Ala Leu Gly Gln Met Pro Ile Ser Pro Asp Leu Ser His Thr
        1315                1320                1325            
Thr Leu Ser Leu Asp Phe Ser Gln Thr Asn Leu Ser Pro Glu Leu Ser
    1330                1335                1340                
Gln Thr Asn Leu Ser Pro Ala Leu Gly Gln Met Pro Leu Ser Pro Asp
1345                1350                1355                1360
Pro Ser His Thr Thr Leu Ser Leu Asp Leu Ser Gln Thr Asn Leu Ser
                1365                1370                1375    
Pro Glu Leu Ser Gln Thr Asn Leu Ser Pro Asp Leu Ser Glu Met Pro
            1380                1385                1390        
Leu Phe Ala Asp Leu Ser Gln Ile Pro Leu Thr Pro Asp Leu Asp Gln
        1395                1400                1405            
Met Thr Leu Ser Pro Asp Leu Gly Glu Thr Asp Leu Ser Pro Asn Phe
    1410                1415                1420                
Gly Gln Met Ser Leu Ser Pro Asp Leu Ser Gln Val Thr Leu Ser Pro
1425                1430                1435                1440
Asp Ile Ser Asp Thr Thr Leu Leu Pro Asp Leu Ser Gln Ile Ser Pro
                1445                1450                1455    
Pro Pro Asp Leu Asp Gln Ile Phe Tyr Pro Ser Glu Ser Ser Gln Ser
            1460                1465                1470        
Leu Leu Leu Gln Glu Phe Asn Glu Ser Phe Pro Tyr Pro Asp Leu Gly
        1475                1480                1485            
Gln Met Pro Ser Pro Ser Ser Pro Thr Leu Asn Asp Thr Phe Leu Ser
    1490                1495                1500                
Lys Glu Phe Asn Pro Leu Val Ile Val Gly Leu Ser Lys Asp Gly Thr
1505                1510                1515                1520
Asp Tyr Ile Glu Ile Ile Pro Lys Glu Glu Val Gln Ser Ser Glu Asp
                1525                1530                1535    
Asp Tyr Ala Glu Ile Asp Tyr Val Pro Tyr Asp Asp Pro Tyr Lys Thr
            1540                1545                1550        
Asp Val Arg Thr Asn Ile Asn Ser Ser Arg Asp Pro Asp Asn Ile Ala
        1555                1560                1565            
Ala Trp Tyr Leu Arg Ser Asn Asn Gly Asn Arg Arg Asn Tyr Tyr Ile
    1570                1575                1580                
Ala Ala Glu Glu Ile Ser Trp Asp Tyr Ser Glu Phe Val Gln Arg Glu
1585                1590                1595                1600
Thr Asp Ile Glu Asp Ser Asp Asp Ile Pro Glu Asp Thr Thr Tyr Lys
                1605                1610                1615    
Lys Val Val Phe Arg Lys Tyr Leu Asp Ser Thr Phe Thr Lys Arg Asp
            1620                1625                1630        
Pro Arg Gly Glu Tyr Glu Glu His Leu Gly Ile Leu Gly Pro Ile Ile
        1635                1640                1645            
Arg Ala Glu Val Asp Asp Val Ile Gln Val Arg Phe Lys Asn Leu Ala
    1650                1655                1660                
Ser Arg Pro Tyr Ser Leu His Ala His Gly Leu Ser Tyr Glu Lys Ser
1665                1670                1675                1680
Ser Glu Gly Lys Thr Tyr Glu Asp Asp Ser Pro Glu Trp Phe Lys Glu
                1685                1690                1695    
Asp Asn Ala Val Gln Pro Asn Ser Ser Tyr Thr Tyr Val Trp His Ala
            1700                1705                1710        
Thr Glu Arg Ser Gly Pro Glu Ser Pro Gly Ser Ala Cys Arg Ala Trp
        1715                1720                1725            
Ala Tyr Tyr Ser Ala Val Asn Pro Glu Lys Asp Ile His Ser Gly Leu
    1730                1735                1740                
Ile Gly Pro Leu Leu Ile Cys Gln Lys Gly Ile Leu His Lys Asp Ser
1745                1750                1755                1760
Asn Met Pro Val Asp Met Arg Glu Phe Val Leu Leu Phe Met Thr Phe
                1765                1770                1775    
Asp Glu Lys Lys Ser Trp Tyr Tyr Glu Lys Lys Ser Arg Ser Ser Trp
            1780                1785                1790        
Arg Leu Thr Ser Ser Glu Met Lys Lys Ser His Glu Phe His Ala Ile
        1795                1800                1805            
Asn Gly Met Ile Tyr Ser Leu Pro Gly Leu Lys Met Tyr Glu Gln Glu
    1810                1815                1820                
Trp Val Arg Leu His Leu Leu Asn Ile Gly Gly Ser Gln Asp Ile His
1825                1830                1835                1840
Val Val His Phe His Gly Gln Thr Leu Leu Glu Asn Gly Asn Lys Gln
                1845                1850                1855    
His Gln Leu Gly Val Trp Pro Leu Leu Pro Gly Ser Phe Lys Thr Leu
            1860                1865                1870        
Glu Met Lys Ala Ser Lys Pro Gly Trp Trp Leu Leu Asn Thr Glu Val
        1875                1880                1885            
Gly Glu Asn Gln Arg Ala Gly Met Gln Thr Pro Phe Leu Ile Met Asp
    1890                1895                1900                
Arg Asp Cys Arg Met Pro Met Gly Leu Ser Thr Gly Ile Ile Ser Asp
1905                1910                1915                1920
Ser Gln Ile Lys Ala Ser Glu Phe Leu Gly Tyr Trp Glu Pro Arg Leu
                1925                1930                1935    
Ala Arg Leu Asn Asn Gly Gly Ser Tyr Asn Ala Trp Ser Val Glu Lys
            1940                1945                1950        
Leu Ala Ala Glu Phe Ala Ser Lys Pro Trp Ile Gln Val Asp Met Gln
        1955                1960                1965            
Lys Glu Val Ile Ile Thr Gly Ile Gln Thr Gln Gly Ala Lys His Tyr
    1970                1975                1980                
Leu Lys Ser Cys Tyr Thr Thr Glu Phe Tyr Val Ala Tyr Ser Ser Asn
1985                1990                1995                2000
Gln Ile Asn Trp Gln Ile Phe Lys Gly Asn Ser Thr Arg Asn Val Met
                2005                2010                2015    
Tyr Phe Asn Gly Asn Ser Asp Ala Ser Thr Ile Lys Glu Asn Gln Phe
            2020                2025                2030        
Asp Pro Pro Ile Val Ala Arg Tyr Ile Arg Ile Ser Pro Thr Arg Ala
        2035                2040                2045            
Tyr Asn Arg Pro Thr Leu Arg Leu Glu Leu Gln Gly Cys Glu Val Asn
    2050                2055                2060                
Gly Cys Ser Thr Pro Leu Gly Met Glu Asn Gly Lys Ile Glu Asn Lys
2065                2070                2075                2080
Gln Ile Thr Ala Ser Ser Phe Lys Lys Ser Trp Trp Gly Asp Tyr Trp
                2085                2090                2095    
Glu Pro Phe Arg Ala Arg Leu Asn Ala Gln Gly Arg Val Asn Ala Trp
            2100                2105                2110        
Gln Ala Lys Ala Asn Asn Asn Lys Gln Trp Leu Glu Ile Asp Leu Leu
        2115                2120                2125            
Lys Ile Lys Lys Ile Thr Ala Ile Ile Thr Gln Gly Cys Lys Ser Leu
    2130                2135                2140                
Ser Ser Glu Met Tyr Val Lys Ser Tyr Thr Ile His Tyr Ser Glu Gln
2145                2150                2155                2160
Gly Val Glu Trp Lys Pro Tyr Arg Leu Lys Ser Ser Met Val Asp Lys
                2165                2170                2175    
Ile Phe Glu Gly Asn Thr Asn Thr Lys Gly His Val Lys Asn Phe Phe
            2180                2185                2190        
Asn Pro Pro Ile Ile Ser Arg Phe Ile Arg Val Ile Pro Lys Thr Trp
        2195                2200                2205            
Asn Gln Ser Ile Thr Leu Arg Leu Glu Leu Phe Gly Cys Asp Ile Tyr
    2210                2215                2220                


<210> 5510
<211> 841
<212> PRT
<213> Homo sapiens

<400> 5510
Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Met Ile Val Met Ala
 1               5                  10                  15      
Ser Leu Cys His Arg Gly Ser Ser Cys Gly Leu Ser Thr His Ile Glu
            20                  25                  30          
Ile Gly His Arg Ala Leu Glu Phe Leu His Leu His Asn Gly His Val
        35                  40                  45              
Asn Tyr Lys Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly
    50                  55                  60                  
Thr Val Phe Pro Asp Cys Phe Tyr Pro Ser Leu Cys Lys Gly Gly Lys
65                  70                  75                  80  
Phe His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala
                85                  90                  95      
Ser Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp
            100                 105                 110         
Thr Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Val
        115                 120                 125             
Ala Asp Val Ser Trp His Ser Leu Gly Ile Glu Gln Gly Phe Leu Arg
    130                 135                 140                 
Thr Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser
145                 150                 155                 160 
Ala Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe
                165                 170                 175     
Asn Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly
            180                 185                 190         
Ile Tyr Glu Lys Leu Tyr Gly Arg Glu Val Ile Thr Glu Asn Val Ile
        195                 200                 205             
Val Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu
    210                 215                 220                 
Ala Val Ser Lys Leu Tyr Pro Ser Tyr Ser Thr Lys Ser Pro Phe Leu
225                 230                 235                 240 
Val Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala
                245                 250                 255     
Phe Trp Ser Thr Asn Ile Tyr His Leu Thr Ser Phe Met Leu Glu Asn
            260                 265                 270         
Gly Thr Ser Asp Cys Ser Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys
        275                 280                 285             
Gly Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp
    290                 295                 300                 
Phe His Arg Asn Leu Thr Ser Ser Leu Thr Glu Asn Ile Asp Arg Asn
305                 310                 315                 320 
Ile Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr
                325                 330                 335     
Pro Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Val Arg
            340                 345                 350         
Thr Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Ile Ser Ser
        355                 360                 365             
Pro Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp
    370                 375                 380                 
Ala Met Thr Ser Ala Asp Leu Asn Gln Asp Gly Tyr Gly Asp Leu Val
385                 390                 395                 400 
Val Gly Ala Pro Gly Tyr Ser Arg Pro Gly Arg Ile His Ile Gly Arg
                405                 410                 415     
Val Tyr Leu Ile Tyr Gly Asn Glu Leu Gly Leu Pro Pro Val Asp Leu
            420                 425                 430         
Asp Leu Asp Lys Glu Ala His Gly Ile Leu Glu Gly Phe Gln Pro Ser
        435                 440                 445             
Gly Arg Phe Gly Ser Ala Leu Ala Met Leu Asp Phe Asn Met Asp Gly
    450                 455                 460                 
Val Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu
465                 470                 475                 480 
Thr Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Arg
                485                 490                 495     
Met Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys
            500                 505                 510         
Asn Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu
        515                 520                 525             
Pro Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln
    530                 535                 540                 
Lys Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asn Lys
545                 550                 555                 560 
Glu Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu
                565                 570                 575     
Asp Phe Ala Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn
            580                 585                 590         
Arg Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg
        595                 600                 605             
Leu Gly Arg Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg
    610                 615                 620                 
Val Tyr Gly Tyr Phe Pro Pro Asn Ser Gln Ser Trp Phe Thr Ile Val
625                 630                 635                 640 
Gly Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His
                645                 650                 655     
Val Leu Met Asn Gly Thr Leu Thr Gln Val Leu Leu Val Gly Ala Pro
            660                 665                 670         
Thr Arg Asp Asp Val Ser Lys Met Ala Phe Leu Thr Met Thr Leu His
        675                 680                 685             
Gln Gly Gly Ala Thr Arg Met Tyr Ala Leu Thr Ser Asp Leu Gln Pro
    690                 695                 700                 
Pro Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly
705                 710                 715                 720 
Gly Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Val Asp Glu Ile
                725                 730                 735     
Ile Val Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile
            740                 745                 750         
Gly Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr
        755                 760                 765             
Leu Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Met Thr Pro Cys Pro
    770                 775                 780                 
Glu Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg
785                 790                 795                 800 
Phe Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val
                805                 810                 815     
Val Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala
            820                 825                 830         
Leu His Val Tyr Ser Phe Gly Ser Asp
        835                 840     


<210> 5511
<211> 605
<212> PRT
<213> Homo sapiens

<400> 5511
Met Ala Leu Arg Lys Gly Gly Leu Ala Leu Ala Leu Leu Leu Leu Ser
 1               5                  10                  15      
Trp Val Ala Leu Gly Pro Arg Ser Leu Glu Gly Ala Asp Pro Gly Thr
            20                  25                  30          
Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro Ala Ala Cys Val Cys Ser
        35                  40                  45              
Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val Phe Cys Ser Ser Arg Asn
    50                  55                  60                  
Leu Thr Arg Leu Pro Asp Gly Val Pro Gly Gly Thr Gln Ala Leu Trp
65                  70                  75                  80  
Leu Asp Gly Asn Asn Leu Ser Ser Val Pro Pro Ala Ala Phe Gln Asn
                85                  90                  95      
Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln Gly Gly Gln Leu Gly Ser
            100                 105                 110         
Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu Asn Leu Cys His Leu His
        115                 120                 125             
Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala Leu Gly Thr Phe Ala His
    130                 135                 140                 
Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser Asn Asn Arg Leu Ser Arg
145                 150                 155                 160 
Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly Ser Leu Trp Asp Leu Asn
                165                 170                 175     
Leu Gly Trp Asn Ser Leu Ala Val Leu Pro Asp Ala Ala Phe Arg Gly
            180                 185                 190         
Leu Gly Ser Leu Arg Glu Leu Val Leu Ala Gly Asn Arg Leu Ala Tyr
        195                 200                 205             
Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala Glu Leu Arg Glu Leu Asp
    210                 215                 220                 
Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys Ala Asn Val Phe Val Gln
225                 230                 235                 240 
Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp Arg Asn Leu Ile Ala Ala
                245                 250                 255     
Val Ala Pro Gly Ala Phe Leu Gly Leu Lys Ala Leu Arg Trp Leu Asp
            260                 265                 270         
Leu Ser His Asn Arg Val Ala Gly Leu Leu Glu Asp Thr Phe Pro Gly
        275                 280                 285             
Leu Leu Gly Leu Arg Val Leu Arg Leu Ser His Asn Ala Ile Ala Ser
    290                 295                 300                 
Leu Arg Pro Arg Thr Phe Lys Asp Leu His Phe Leu Glu Glu Leu Gln
305                 310                 315                 320 
Leu Gly His Asn Arg Ile Arg Gln Leu Ala Glu Arg Ser Phe Glu Gly
                325                 330                 335     
Leu Gly Gln Leu Glu Val Leu Thr Leu Asp His Asn Gln Leu Gln Glu
            340                 345                 350         
Val Lys Ala Gly Ala Phe Leu Gly Leu Thr Asn Val Ala Val Met Asn
        355                 360                 365             
Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro Glu Gln Val Phe Arg Gly
    370                 375                 380                 
Leu Gly Lys Leu His Ser Leu His Leu Glu Gly Ser Cys Leu Gly Arg
385                 390                 395                 400 
Ile Arg Pro His Thr Phe Thr Gly Leu Ser Gly Leu Arg Arg Leu Phe
                405                 410                 415     
Leu Lys Asp Asn Gly Leu Val Gly Ile Glu Glu Gln Ser Leu Trp Gly
            420                 425                 430         
Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr Ser Asn Gln Leu Thr His
        435                 440                 445             
Leu Pro His Arg Leu Phe Gln Gly Leu Gly Lys Leu Glu Tyr Leu Leu
    450                 455                 460                 
Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro Ala Asp Ala Leu Gly Pro
465                 470                 475                 480 
Leu Gln Arg Ala Phe Trp Leu Asp Val Ser His Asn Arg Leu Glu Ala
                485                 490                 495     
Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly Arg Leu Arg Tyr Leu Ser
            500                 505                 510         
Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr Pro Gln Pro Pro Gly Leu
        515                 520                 525             
Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp Asp Cys Gly Cys Pro Leu
    530                 535                 540                 
Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Ser Ala Val Pro Arg
545                 550                 555                 560 
Phe Val Gln Ala Ile Cys Glu Gly Asp Asp Cys Gln Pro Pro Ala Tyr
                565                 570                 575     
Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro Pro Glu Val Val Gly Leu
            580                 585                 590         
Asp Leu Arg Asp Leu Ser Glu Ala His Phe Ala Pro Cys
        595                 600                 605 


<210> 5512
<211> 934
<212> PRT
<213> Homo sapiens

<400> 5512
Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile
 1               5                  10                  15      
Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp
            20                  25                  30          
Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg
        35                  40                  45              
Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile
    50                  55                  60                  
Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile
65                  70                  75                  80  
Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys
                85                  90                  95      
Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe
            100                 105                 110         
Gly Gly Gln Pro Cys Thr Glu Pro Leu Val Ala Phe Gln Pro Cys Ile
        115                 120                 125             
Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe
    130                 135                 140                 
Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly
145                 150                 155                 160 
Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr
                165                 170                 175     
Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu
            180                 185                 190         
Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val
        195                 200                 205             
Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser
    210                 215                 220                 
Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly
225                 230                 235                 240 
Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys
                245                 250                 255     
Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser
            260                 265                 270         
Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys
        275                 280                 285             
Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln
    290                 295                 300                 
Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met
305                 310                 315                 320 
Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp
                325                 330                 335     
Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala
            340                 345                 350         
Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser
        355                 360                 365             
Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu
    370                 375                 380                 
Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val
385                 390                 395                 400 
Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val
                405                 410                 415     
Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser
            420                 425                 430         
Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg
        435                 440                 445             
Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu
    450                 455                 460                 
Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro
465                 470                 475                 480 
Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn
                485                 490                 495     
Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln
            500                 505                 510         
Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn
        515                 520                 525             
Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln
    530                 535                 540                 
Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys
545                 550                 555                 560 
Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr
                565                 570                 575     
Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro
            580                 585                 590         
Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu
        595                 600                 605             
Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile
    610                 615                 620                 
Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala
625                 630                 635                 640 
Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg
                645                 650                 655     
Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys
            660                 665                 670         
Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro
        675                 680                 685             
Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys
    690                 695                 700                 
Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg
705                 710                 715                 720 
Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe
                725                 730                 735     
Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr
            740                 745                 750         
Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys
        755                 760                 765             
Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys
    770                 775                 780                 
Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu
785                 790                 795                 800 
Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys
                805                 810                 815     
Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu
            820                 825                 830         
His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu
        835                 840                 845             
Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr
    850                 855                 860                 
Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys
865                 870                 875                 880 
Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr
                885                 890                 895     
Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys
            900                 905                 910         
Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His
        915                 920                 925             
Pro Gly Lys Cys Leu Ala
    930                 


<210> 5513
<211> 330
<212> PRT
<213> Homo sapiens

<400> 5513
Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala
 1               5                  10                  15      
Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly
            20                  25                  30          
Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly
        35                  40                  45              
Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly
    50                  55                  60                  
Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala
65                  70                  75                  80  
Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr
                85                  90                  95      
Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val
            100                 105                 110         
Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr
        115                 120                 125             
Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg
    130                 135                 140                 
Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu
145                 150                 155                 160 
Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys
                165                 170                 175     
Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys
            180                 185                 190         
Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn Ser Ser Glu
        195                 200                 205             
Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe
    210                 215                 220                 
Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln
225                 230                 235                 240 
Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly
                245                 250                 255     
Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu
            260                 265                 270         
Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg Ser Asp Arg
        275                 280                 285             
Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu
    290                 295                 300                 
Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala Val Cys Arg
305                 310                 315                 320 
Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu
                325                 330 


<210> 5514
<211> 147
<212> PRT
<213> Homo sapiens

<400> 5514
Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe
 1               5                  10                  15      
Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu
            20                  25                  30          
Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val
        35                  40                  45              
Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe
    50                  55                  60                  
Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr
65                  70                  75                  80  
Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys
                85                  90                  95      
Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu
            100                 105                 110         
Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala
        115                 120                 125             
Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn
    130                 135                 140                 
Pro Lys Glu
145         


<210> 5515
<211> 288
<212> PRT
<213> Homo sapiens

<400> 5515
Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly
 1               5                  10                  15      
Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro
            20                  25                  30          
Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly
        35                  40                  45              
Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro
    50                  55                  60                  
Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg
65                  70                  75                  80  
Asn Cys Arg Glu Leu Leu Ser Gln Gly Ala Thr Leu Ser Gly Trp Tyr
                85                  90                  95      
His Leu Cys Leu Pro Glu Gly Arg Ala Leu Pro Val Phe Cys Asp Met
            100                 105                 110         
Asp Thr Glu Gly Gly Gly Trp Leu Val Phe Gln Arg Arg Gln Asp Gly
        115                 120                 125             
Ser Val Asp Phe Phe Arg Ser Trp Ser Ser Tyr Arg Ala Gly Phe Gly
    130                 135                 140                 
Asn Gln Glu Ser Glu Phe Trp Leu Gly Asn Glu Asn Leu His Gln Leu
145                 150                 155                 160 
Thr Leu Gln Gly Asn Trp Glu Leu Arg Val Glu Leu Glu Asp Phe Asn
                165                 170                 175     
Gly Asn Arg Thr Phe Ala His Tyr Ala Thr Phe Arg Leu Leu Gly Glu
            180                 185                 190         
Val Asp His Tyr Gln Leu Ala Leu Gly Lys Phe Ser Glu Gly Thr Ala
        195                 200                 205             
Gly Asp Ser Leu Ser Leu His Ser Gly Arg Pro Phe Thr Thr Tyr Asp
    210                 215                 220                 
Ala Asp His Asp Ser Ser Asn Ser Asn Cys Ala Val Ile Val His Gly
225                 230                 235                 240 
Ala Trp Trp Tyr Ala Ser Cys Tyr Arg Ser Asn Leu Asn Gly Arg Tyr
                245                 250                 255     
Ala Val Ser Asp Ala Ala Ala His Lys Tyr Gly Ile Asp Trp Ala Ser
            260                 265                 270         
Gly Arg Gly Val Gly His Pro Tyr Arg Arg Val Arg Met Met Leu Arg
        275                 280                 285             


<210> 5516
<211> 299
<212> PRT
<213> Homo sapiens

<400> 5516
Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly
 1               5                  10                  15      
Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro
            20                  25                  30          
Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly
        35                  40                  45              
Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro
    50                  55                  60                  
Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Asp Pro
65                  70                  75                  80  
Val Asn Leu Leu Arg Cys Gln Glu Gly Pro Arg Asn Cys Arg Glu Leu
                85                  90                  95      
Leu Ser Gln Gly Ala Thr Leu Ser Gly Trp Tyr His Leu Cys Leu Pro
            100                 105                 110         
Glu Gly Arg Ala Leu Pro Val Phe Cys Asp Met Asp Thr Glu Gly Gly
        115                 120                 125             
Gly Trp Leu Val Phe Gln Arg Arg Gln Asp Gly Ser Val Asp Phe Phe
    130                 135                 140                 
Arg Ser Trp Ser Ser Tyr Arg Ala Gly Phe Gly Asn Gln Glu Ser Glu
145                 150                 155                 160 
Phe Trp Leu Gly Asn Glu Asn Leu His Gln Leu Thr Leu Gln Gly Asn
                165                 170                 175     
Trp Glu Leu Arg Val Glu Leu Glu Asp Phe Asn Gly Asn Arg Thr Phe
            180                 185                 190         
Ala His Tyr Ala Thr Phe Arg Leu Leu Gly Glu Val Asp His Tyr Gln
        195                 200                 205             
Leu Ala Leu Gly Lys Phe Ser Glu Gly Thr Ala Gly Asp Ser Leu Ser
    210                 215                 220                 
Leu His Ser Gly Arg Pro Phe Thr Thr Tyr Asp Ala Asp His Asp Ser
225                 230                 235                 240 
Ser Asn Ser Asn Cys Ala Val Ile Val His Gly Ala Trp Trp Tyr Ala
                245                 250                 255     
Ser Cys Tyr Arg Ser Asn Leu Asn Gly Arg Tyr Ala Val Ser Asp Ala
            260                 265                 270         
Ala Ala His Lys Tyr Gly Ile Asp Trp Ala Ser Gly Arg Gly Val Gly
        275                 280                 285             
His Pro Tyr Arg Arg Val Arg Met Met Leu Arg
    290                 295                 


<210> 5517
<211> 402
<212> PRT
<213> Homo sapiens

<400> 5517
Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp Ala Leu Arg Pro
            20                  25                  30          
Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val His Leu Ser
        35                  40                  45              
Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe Asp Leu Thr
    50                  55                  60                  
Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr Trp Asp Pro
65                  70                  75                  80  
Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe
                85                  90                  95      
Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His
            100                 105                 110         
Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg
        115                 120                 125             
Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu Glu
    130                 135                 140                 
Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser Gly Pro Leu
145                 150                 155                 160 
Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly Gly Leu Leu
                165                 170                 175     
Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala Leu Asp Gly
            180                 185                 190         
Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala
        195                 200                 205             
Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly
    210                 215                 220                 
Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile
225                 230                 235                 240 
Pro Gln Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu
                245                 250                 255     
Lys Gln Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly Thr Pro Glu
            260                 265                 270         
Asn Pro Ser Trp Leu Ser Leu His Leu Gln Asp Gln Lys Val Val Leu
        275                 280                 285             
Ser Ser Gly Ser Gly Pro Gly Leu Asp Leu Pro Leu Val Leu Gly Leu
    290                 295                 300                 
Pro Leu Gln Leu Lys Leu Ser Met Ser Arg Val Val Leu Ser Gln Gly
305                 310                 315                 320 
Ser Lys Met Lys Ala Leu Ala Leu Pro Pro Leu Gly Leu Ala Pro Leu
                325                 330                 335     
Leu Asn Leu Trp Ala Lys Pro Gln Gly Arg Leu Phe Leu Gly Ala Leu
            340                 345                 350         
Pro Gly Glu Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly Leu Trp Ala
        355                 360                 365             
Gln Gly Gln Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser His Glu
    370                 375                 380                 
Ile Trp Thr His Ser Cys Pro Gln Ser Pro Gly Asn Gly Thr Asp Ala
385                 390                 395                 400 
Ser His
        


<210> 5518
<211> 615
<212> PRT
<213> Homo sapiens

<400> 5518
Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser
 1               5                  10                  15      
Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys
            20                  25                  30          
Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His
        35                  40                  45              
Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys
    50                  55                  60                  
Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp
65                  70                  75                  80  
Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp
                85                  90                  95      
His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn
            100                 105                 110         
Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn
        115                 120                 125             
His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe
    130                 135                 140                 
His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg
145                 150                 155                 160 
Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln
                165                 170                 175     
Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val
            180                 185                 190         
Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Pro Phe
        195                 200                 205             
Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser
    210                 215                 220                 
Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro
225                 230                 235                 240 
Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg
                245                 250                 255     
Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp
            260                 265                 270         
Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu
        275                 280                 285             
Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro
    290                 295                 300                 
Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro
305                 310                 315                 320 
Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln
                325                 330                 335     
Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr
            340                 345                 350         
Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser
        355                 360                 365             
Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His
    370                 375                 380                 
Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser
385                 390                 395                 400 
Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp
                405                 410                 415     
Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg
            420                 425                 430         
Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg
        435                 440                 445             
Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu
    450                 455                 460                 
Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro
465                 470                 475                 480 
Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu
                485                 490                 495     
Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala
            500                 505                 510         
Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser
        515                 520                 525             
Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro
    530                 535                 540                 
Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln
545                 550                 555                 560 
Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg
                565                 570                 575     
Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp
            580                 585                 590         
Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp
        595                 600                 605             
Ile Arg Glu His Thr Val Ser
    610                 615 


<210> 5519
<211> 176
<212> PRT
<213> Homo sapiens

<400> 5519
Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser
 1               5                  10                  15      
Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile
            20                  25                  30          
Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn
        35                  40                  45              
Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile
    50                  55                  60                  
Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe
65                  70                  75                  80  
His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser
                85                  90                  95      
Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr
            100                 105                 110         
Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala
        115                 120                 125             
Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr
    130                 135                 140                 
Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala
145                 150                 155                 160 
Gly Asp Phe Gly Thr Val Tyr Leu His Leu Leu Asn Phe Leu Val Val
                165                 170                 175     


<210> 5520
<211> 625
<212> PRT
<213> Homo sapiens

<400> 5520
Met Ile Phe Leu Tyr Gln Val Val His Phe Ile Leu Phe Thr Ser Val
 1               5                  10                  15      
Ser Gly Glu Cys Val Thr Gln Leu Leu Lys Asp Thr Cys Phe Glu Gly
            20                  25                  30          
Gly Asp Ile Thr Thr Val Phe Thr Pro Ser Ala Lys Tyr Cys Gln Val
        35                  40                  45              
Val Cys Thr Tyr His Pro Arg Cys Leu Leu Phe Thr Phe Thr Ala Glu
    50                  55                  60                  
Ser Pro Ser Glu Asp Pro Thr Arg Trp Phe Thr Cys Val Leu Lys Asp
65                  70                  75                  80  
Ser Val Thr Glu Thr Leu Pro Arg Val Asn Arg Thr Ala Ala Ile Ser
                85                  90                  95      
Gly Tyr Ser Phe Lys Gln Cys Ser His Gln Ile Ser Ala Cys Asn Lys
            100                 105                 110         
Asp Ile Tyr Val Asp Leu Asp Met Lys Gly Ile Asn Tyr Asn Ser Ser
        115                 120                 125             
Val Ala Lys Ser Ala Gln Glu Cys Gln Glu Arg Cys Thr Asp Asp Val
    130                 135                 140                 
His Cys His Phe Phe Thr Tyr Ala Thr Arg Gln Phe Pro Ser Leu Glu
145                 150                 155                 160 
His Arg Asn Ile Cys Leu Leu Lys His Thr Gln Thr Gly Thr Pro Thr
                165                 170                 175     
Arg Ile Thr Lys Leu Asp Lys Val Val Ser Gly Phe Ser Leu Lys Ser
            180                 185                 190         
Cys Ala Leu Ser Asn Leu Ala Cys Ile Arg Asp Ile Phe Pro Asn Thr
        195                 200                 205             
Val Phe Ala Asp Ser Asn Ile Asp Ser Val Met Ala Pro Asp Ala Phe
    210                 215                 220                 
Val Cys Gly Arg Ile Cys Thr His His Pro Gly Cys Leu Phe Phe Thr
225                 230                 235                 240 
Phe Phe Ser Gln Glu Trp Pro Lys Glu Ser Gln Arg Asn Leu Cys Leu
                245                 250                 255     
Leu Lys Thr Ser Glu Ser Gly Leu Pro Ser Thr Arg Ile Lys Lys Ser
            260                 265                 270         
Lys Ala Leu Ser Gly Phe Ser Leu Gln Ser Cys Arg His Ser Ile Pro
        275                 280                 285             
Val Phe Cys His Ser Ser Phe Tyr His Asp Thr Asp Phe Leu Gly Glu
    290                 295                 300                 
Glu Leu Asp Ile Val Ala Ala Lys Ser His Glu Ala Cys Gln Lys Leu
305                 310                 315                 320 
Cys Thr Asn Ala Val Arg Cys Gln Phe Phe Thr Tyr Thr Pro Ala Gln
                325                 330                 335     
Ala Ser Cys Asn Glu Gly Lys Gly Lys Cys Tyr Leu Lys Leu Ser Ser
            340                 345                 350         
Asn Gly Ser Pro Thr Lys Ile Leu His Gly Arg Gly Gly Ile Ser Gly
        355                 360                 365             
Tyr Thr Leu Arg Leu Cys Lys Met Asp Asn Glu Cys Thr Thr Lys Ile
    370                 375                 380                 
Lys Pro Arg Ile Val Gly Gly Thr Ala Ser Val Arg Gly Glu Trp Pro
385                 390                 395                 400 
Trp Gln Val Thr Leu His Thr Thr Ser Pro Thr Gln Arg His Leu Cys
                405                 410                 415     
Gly Gly Ser Ile Ile Gly Asn Gln Trp Ile Leu Thr Ala Ala His Cys
            420                 425                 430         
Phe Tyr Gly Val Glu Ser Pro Lys Ile Leu Arg Val Tyr Ser Gly Ile
        435                 440                 445             
Leu Asn Gln Ser Glu Ile Lys Glu Asp Thr Ser Phe Phe Gly Val Gln
    450                 455                 460                 
Glu Ile Ile Ile His Asp Gln Tyr Lys Met Ala Glu Ser Gly Tyr Asp
465                 470                 475                 480 
Ile Ala Leu Leu Lys Leu Glu Thr Thr Val Asn Tyr Thr Asp Ser Gln
                485                 490                 495     
Arg Pro Ile Cys Leu Pro Ser Lys Gly Asp Arg Asn Val Ile Tyr Thr
            500                 505                 510         
Asp Cys Trp Val Thr Gly Trp Gly Tyr Arg Lys Leu Arg Asp Lys Ile
        515                 520                 525             
Gln Asn Thr Leu Gln Lys Ala Lys Ile Pro Leu Val Thr Asn Glu Glu
    530                 535                 540                 
Cys Gln Lys Arg Tyr Arg Gly His Lys Ile Thr His Lys Met Ile Cys
545                 550                 555                 560 
Ala Gly Tyr Arg Glu Gly Gly Lys Asp Ala Cys Lys Gly Asp Ser Gly
                565                 570                 575     
Gly Pro Leu Ser Cys Lys His Asn Glu Val Trp His Leu Val Gly Ile
            580                 585                 590         
Thr Ser Trp Gly Glu Gly Cys Ala Gln Arg Glu Arg Pro Gly Val Tyr
        595                 600                 605             
Thr Asn Val Val Glu Tyr Val Asp Trp Ile Leu Glu Lys Thr Gln Ala
    610                 615                 620                 
Val
625 


<210> 5521
<211> 571
<212> PRT
<213> Homo sapiens

<400> 5521
Met Ile Phe Leu Tyr Gln Val Val His Phe Ile Leu Phe Thr Ser Val
 1               5                  10                  15      
Ser Gly Glu Cys Val Thr Gln Leu Leu Lys Asp Thr Cys Phe Glu Gly
            20                  25                  30          
Gly Asp Ile Thr Thr Val Phe Thr Pro Ser Ala Lys Tyr Cys Gln Val
        35                  40                  45              
Val Cys Thr Tyr His Pro Arg Cys Leu Leu Phe Thr Phe Thr Ala Glu
    50                  55                  60                  
Ser Pro Ser Glu Asp Pro Thr Arg Trp Phe Thr Cys Val Leu Lys Asp
65                  70                  75                  80  
Ser Val Thr Glu Thr Leu Pro Arg Val Asn Arg Thr Ala Ala Ile Ser
                85                  90                  95      
Gly Tyr Ser Phe Lys Gln Cys Ser His Gln Ile Ser Asn Ile Cys Leu
            100                 105                 110         
Leu Lys His Thr Gln Thr Gly Thr Pro Thr Arg Ile Thr Lys Leu Asp
        115                 120                 125             
Lys Val Val Ser Gly Phe Ser Leu Lys Ser Cys Ala Leu Ser Asn Leu
    130                 135                 140                 
Ala Cys Ile Arg Asp Ile Phe Pro Asn Thr Val Phe Ala Asp Ser Asn
145                 150                 155                 160 
Ile Asp Ser Val Met Ala Pro Asp Ala Phe Val Cys Gly Arg Ile Cys
                165                 170                 175     
Thr His His Pro Gly Cys Leu Phe Phe Thr Phe Phe Ser Gln Glu Trp
            180                 185                 190         
Pro Lys Glu Ser Gln Arg Asn Leu Cys Leu Leu Lys Thr Ser Glu Ser
        195                 200                 205             
Gly Leu Pro Ser Thr Arg Ile Lys Lys Ser Lys Ala Leu Ser Gly Phe
    210                 215                 220                 
Ser Leu Gln Ser Cys Arg His Ser Ile Pro Val Phe Cys His Ser Ser
225                 230                 235                 240 
Phe Tyr His Asp Thr Asp Phe Leu Gly Glu Glu Leu Asp Ile Val Ala
                245                 250                 255     
Ala Lys Ser His Glu Ala Cys Gln Lys Leu Cys Thr Asn Ala Val Arg
            260                 265                 270         
Cys Gln Phe Phe Thr Tyr Thr Pro Ala Gln Ala Ser Cys Asn Glu Gly
        275                 280                 285             
Lys Gly Lys Cys Tyr Leu Lys Leu Ser Ser Asn Gly Ser Pro Thr Lys
    290                 295                 300                 
Ile Leu His Gly Arg Gly Gly Ile Ser Gly Tyr Thr Leu Arg Leu Cys
305                 310                 315                 320 
Lys Met Asp Asn Glu Cys Thr Thr Lys Ile Lys Pro Arg Ile Val Gly
                325                 330                 335     
Gly Thr Ala Ser Val Arg Gly Glu Trp Pro Trp Gln Val Thr Leu His
            340                 345                 350         
Thr Thr Ser Pro Thr Gln Arg His Leu Cys Gly Gly Ser Ile Ile Gly
        355                 360                 365             
Asn Gln Trp Ile Leu Thr Ala Ala His Cys Phe Tyr Gly Val Glu Ser
    370                 375                 380                 
Pro Lys Ile Leu Arg Val Tyr Ser Gly Ile Leu Asn Gln Ser Glu Ile
385                 390                 395                 400 
Lys Glu Asp Thr Ser Phe Phe Gly Val Gln Glu Ile Ile Ile His Asp
                405                 410                 415     
Gln Tyr Lys Met Ala Glu Ser Gly Tyr Asp Ile Ala Leu Leu Lys Leu
            420                 425                 430         
Glu Thr Thr Val Asn Tyr Thr Asp Ser Gln Arg Pro Ile Cys Leu Pro
        435                 440                 445             
Ser Lys Gly Asp Arg Asn Val Ile Tyr Thr Asp Cys Trp Val Thr Gly
    450                 455                 460                 
Trp Gly Tyr Arg Lys Leu Arg Asp Lys Ile Gln Asn Thr Leu Gln Lys
465                 470                 475                 480 
Ala Lys Ile Pro Leu Val Thr Asn Glu Glu Cys Gln Lys Arg Tyr Arg
                485                 490                 495     
Gly His Lys Ile Thr His Lys Met Ile Cys Ala Gly Tyr Arg Glu Gly
            500                 505                 510         
Gly Lys Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Ser Cys Lys
        515                 520                 525             
His Asn Glu Val Trp His Leu Val Gly Ile Thr Ser Trp Gly Glu Gly
    530                 535                 540                 
Cys Ala Gln Arg Glu Arg Pro Gly Val Tyr Thr Asn Val Val Glu Tyr
545                 550                 555                 560 
Val Asp Trp Ile Leu Glu Lys Thr Gln Ala Val
                565                 570     


<210> 5522
<211> 676
<212> PRT
<213> Homo sapiens

<400> 5522
Met Arg Val Leu Gly Gly Arg Cys Gly Ala Leu Leu Ala Cys Leu Leu
 1               5                  10                  15      
Leu Val Leu Pro Val Ser Glu Ala Asn Phe Leu Ser Lys Gln Gln Ala
            20                  25                  30          
Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu
        35                  40                  45              
Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn
    50                  55                  60                  
Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr
65                  70                  75                  80  
Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu
                85                  90                  95      
Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser
            100                 105                 110         
Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu
        115                 120                 125             
Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr
    130                 135                 140                 
Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu
145                 150                 155                 160 
Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp
                165                 170                 175     
Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met
            180                 185                 190         
Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys
        195                 200                 205             
Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe
    210                 215                 220                 
Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser
225                 230                 235                 240 
Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys
                245                 250                 255     
Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly
            260                 265                 270         
Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys
        275                 280                 285             
Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu
    290                 295                 300                 
Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile
305                 310                 315                 320 
Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly
                325                 330                 335     
Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile
            340                 345                 350         
Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr
        355                 360                 365             
Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn
    370                 375                 380                 
Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala
385                 390                 395                 400 
Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro
                405                 410                 415     
Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg
            420                 425                 430         
Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly
        435                 440                 445             
Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys
    450                 455                 460                 
Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu
465                 470                 475                 480 
Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp
                485                 490                 495     
Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu
            500                 505                 510         
Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser
        515                 520                 525             
Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser
    530                 535                 540                 
Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr
545                 550                 555                 560 
Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu
                565                 570                 575     
Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile
            580                 585                 590         
Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp
        595                 600                 605             
Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp
    610                 615                 620                 
Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met
625                 630                 635                 640 
Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser
                645                 650                 655     
Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys
            660                 665                 670         
Thr Lys Asn Ser
        675     


<210> 5523
<211> 764
<212> PRT
<213> Homo sapiens

<400> 5523
Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile
 1               5                  10                  15      
Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu
            20                  25                  30          
Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn
        35                  40                  45              
Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys
    50                  55                  60                  
Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly
65                  70                  75                  80  
Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn
                85                  90                  95      
Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu
            100                 105                 110         
Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser
        115                 120                 125             
Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu
    130                 135                 140                 
Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln
145                 150                 155                 160 
Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val
                165                 170                 175     
Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg
            180                 185                 190         
Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn
        195                 200                 205             
Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp
    210                 215                 220                 
Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro
225                 230                 235                 240 
Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His
                245                 250                 255     
Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg
            260                 265                 270         
Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys
        275                 280                 285             
Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys
    290                 295                 300                 
Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala
305                 310                 315                 320 
Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly
                325                 330                 335     
Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile
            340                 345                 350         
Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala
        355                 360                 365             
Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp
    370                 375                 380                 
Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp
385                 390                 395                 400 
Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu
                405                 410                 415     
Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr
            420                 425                 430         
Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu
        435                 440                 445             
Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu
    450                 455                 460                 
Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val
465                 470                 475                 480 
Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys
                485                 490                 495     
Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly
            500                 505                 510         
Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser
        515                 520                 525             
Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys
    530                 535                 540                 
Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val
545                 550                 555                 560 
Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala
                565                 570                 575     
Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg
            580                 585                 590         
Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu
        595                 600                 605             
Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser
    610                 615                 620                 
Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Ala Leu
625                 630                 635                 640 
Val Ser Thr Leu Val Pro Leu Gly Leu Val Leu Ala Val Gly Ala Val
                645                 650                 655     
Ala Val Gly Val Ala Arg Ala Arg His Arg Lys Asn Val Asp Arg Val
            660                 665                 670         
Ser Ile Arg Ser Tyr Arg Thr Asp Ile Ser Met Ser Asp Phe Glu Asn
        675                 680                 685             
Ser Arg Glu Phe Gly Ala Asn Asp Asn Met Gly Ala Ser Ser Ile Thr
    690                 695                 700                 
Gln Glu Thr Ser Leu Gly Gly Lys Glu Glu Phe Val Ala Thr Thr Glu
705                 710                 715                 720 
Ser Thr Thr Glu Thr Lys Glu Pro Lys Lys Ala Lys Arg Ser Ser Lys
                725                 730                 735     
Glu Glu Ala Glu Met Ala Tyr Lys Asp Phe Leu Leu Gln Ser Ser Thr
            740                 745                 750         
Val Ala Ala Glu Ala Gln Asp Gly Pro Gln Glu Ala
        755                 760                 


<210> 5524
<211> 764
<212> PRT
<213> Homo sapiens

<400> 5524
Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile
 1               5                  10                  15      
Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu
            20                  25                  30          
Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn
        35                  40                  45              
Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys
    50                  55                  60                  
Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly
65                  70                  75                  80  
Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn
                85                  90                  95      
Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu
            100                 105                 110         
Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser
        115                 120                 125             
Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu
    130                 135                 140                 
Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln
145                 150                 155                 160 
Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val
                165                 170                 175     
Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg
            180                 185                 190         
Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn
        195                 200                 205             
Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp
    210                 215                 220                 
Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro
225                 230                 235                 240 
Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His
                245                 250                 255     
Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg
            260                 265                 270         
Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys
        275                 280                 285             
Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys
    290                 295                 300                 
Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala
305                 310                 315                 320 
Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly
                325                 330                 335     
Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile
            340                 345                 350         
Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Ser Ser Val Ala
        355                 360                 365             
Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp
    370                 375                 380                 
Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp
385                 390                 395                 400 
Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu
                405                 410                 415     
Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr
            420                 425                 430         
Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu
        435                 440                 445             
Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu
    450                 455                 460                 
Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val
465                 470                 475                 480 
Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys
                485                 490                 495     
Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly
            500                 505                 510         
Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser
        515                 520                 525             
Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys
    530                 535                 540                 
Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val
545                 550                 555                 560 
Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala
                565                 570                 575     
Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg
            580                 585                 590         
Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu
        595                 600                 605             
Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser
    610                 615                 620                 
Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Ala Leu
625                 630                 635                 640 
Val Ser Thr Leu Val Pro Leu Gly Leu Val Leu Ala Val Gly Ala Val
                645                 650                 655     
Ala Val Gly Val Ala Arg Ala Arg His Arg Lys Asn Val Asp Arg Val
            660                 665                 670         
Ser Ile Arg Ser Tyr Arg Thr Asp Ile Ser Met Ser Asp Phe Glu Asn
        675                 680                 685             
Ser Arg Glu Phe Gly Ala Asn Asp Asn Met Gly Ala Ser Ser Ile Thr
    690                 695                 700                 
Gln Glu Thr Ser Leu Gly Gly Lys Glu Glu Phe Val Ala Thr Thr Glu
705                 710                 715                 720 
Ser Thr Thr Glu Thr Lys Glu Pro Lys Lys Ala Lys Arg Ser Ser Lys
                725                 730                 735     
Glu Glu Ala Glu Met Ala Tyr Lys Asp Phe Leu Leu Gln Ser Ser Thr
            740                 745                 750         
Val Ala Ala Glu Ala Gln Asp Gly Pro Gln Glu Ala
        755                 760                 


<210> 5525
<211> 505
<212> PRT
<213> Homo sapiens

<400> 5525
Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu Trp
 1               5                  10                  15      
Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg Ala
            20                  25                  30          
Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr Ser
        35                  40                  45              
Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile Asp
    50                  55                  60                  
Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met Val
65                  70                  75                  80  
Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu Asn
                85                  90                  95      
Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val Gln
            100                 105                 110         
Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val Phe
        115                 120                 125             
Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp Arg
    130                 135                 140                 
Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu Asp Val Leu
145                 150                 155                 160 
Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala Phe
                165                 170                 175     
Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu
            180                 185                 190         
Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly Phe
        195                 200                 205             
Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val Asn
    210                 215                 220                 
Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser Leu
225                 230                 235                 240 
Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys Leu
                245                 250                 255     
Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser Gly
            260                 265                 270         
Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Gly Asn
        275                 280                 285             
Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile Gly Thr Glu Thr Arg
    290                 295                 300                 
Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr Pro Leu Asn Arg Lys
305                 310                 315                 320 
Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu Phe
                325                 330                 335     
His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu Val Lys Gly Glu Leu
            340                 345                 350         
Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys Phe Gly Leu Asn
        355                 360                 365             
Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe Ile Asn Ser Ile Gly
    370                 375                 380                 
Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro Glu Pro Ser Thr Asp
385                 390                 395                 400 
Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu Thr Leu Thr Lys Ala
                405                 410                 415     
Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr Ala Val Lys Lys Pro
            420                 425                 430         
Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu Lys Cys Pro Ser Ile
        435                 440                 445             
Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly Ile Glu Cys Ala Ala
    450                 455                 460                 
Ser Ala Met Glu Met Ser Ala Ile Ala Ala His Asn Ala Ala Leu Leu
465                 470                 475                 480 
Ala Tyr His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp Gly
                485                 490                 495     
Leu Tyr Glu Lys Leu Lys Thr Glu Leu
            500                 505 


<210> 5526
<211> 505
<212> PRT
<213> Homo sapiens

<400> 5526
Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu Trp
 1               5                  10                  15      
Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg Ala
            20                  25                  30          
Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr Ser
        35                  40                  45              
Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile Asp
    50                  55                  60                  
Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met Val
65                  70                  75                  80  
Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu Asn
                85                  90                  95      
Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val Gln
            100                 105                 110         
Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val Phe
        115                 120                 125             
Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp Arg
    130                 135                 140                 
Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu Asp Val Leu
145                 150                 155                 160 
Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala Phe
                165                 170                 175     
Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu
            180                 185                 190         
Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly Phe
        195                 200                 205             
Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val Asn
    210                 215                 220                 
Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser Leu
225                 230                 235                 240 
Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys Leu
                245                 250                 255     
Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser Gly
            260                 265                 270         
Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Gly Asn
        275                 280                 285             
Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile Gly Thr Glu Thr Arg
    290                 295                 300                 
Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr Pro Leu Asn Arg Lys
305                 310                 315                 320 
Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu Phe
                325                 330                 335     
His Gln Tyr Tyr His His Ile Val Thr Thr Leu Val Lys Gly Glu Leu
            340                 345                 350         
Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys Phe Gly Leu Asn
        355                 360                 365             
Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe Ile Asn Ser Ile Gly
    370                 375                 380                 
Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro Glu Pro Ser Thr Asp
385                 390                 395                 400 
Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu Thr Leu Thr Lys Ala
                405                 410                 415     
Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr Ala Val Lys Lys Pro
            420                 425                 430         
Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu Lys Cys Pro Ser Ile
        435                 440                 445             
Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly Ile Glu Cys Ala Ala
    450                 455                 460                 
Ser Ala Met Glu Met Ser Ala Ile Ala Ala His Asn Ala Ala Leu Leu
465                 470                 475                 480 
Ala Tyr His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp Gly
                485                 490                 495     
Leu Tyr Glu Lys Leu Lys Thr Glu Leu
            500                 505 


<210> 5527
<211> 508
<212> PRT
<213> Homo sapiens

<400> 5527
Met Asp Pro Lys Leu Gly Arg Met Ala Ala Ser Leu Leu Ala Val Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Glu Arg Gly Met Phe Ser Ser Pro Ser Pro Pro
            20                  25                  30          
Pro Ala Leu Leu Glu Lys Val Phe Gln Tyr Ile Asp Leu His Gln Asp
        35                  40                  45              
Glu Phe Val Gln Thr Leu Lys Glu Trp Val Ala Ile Glu Ser Asp Ser
    50                  55                  60                  
Val Gln Pro Val Pro Arg Phe Arg Gln Glu Leu Phe Arg Met Met Ala
65                  70                  75                  80  
Val Ala Ala Asp Thr Leu Gln Arg Leu Gly Ala Arg Val Ala Ser Val
                85                  90                  95      
Asp Met Gly Pro Gln Gln Leu Pro Asp Gly Gln Ser Leu Pro Ile Pro
            100                 105                 110         
Pro Val Ile Leu Ala Glu Leu Gly Ser Asp Pro Thr Lys Gly Thr Val
        115                 120                 125             
Cys Phe Tyr Gly His Leu Asp Val Gln Pro Ala Asp Arg Gly Asp Gly
    130                 135                 140                 
Trp Leu Thr Asp Pro Tyr Val Leu Thr Glu Val Gly Gly Lys Leu Tyr
145                 150                 155                 160 
Gly Arg Gly Ala Thr Asp Asn Lys Gly Pro Val Leu Ala Trp Ile Asn
                165                 170                 175     
Ala Val Ser Ala Phe Arg Ala Leu Glu Gln Asp Leu Pro Val Asn Ile
            180                 185                 190         
Lys Phe Ile Ile Glu Gly Met Glu Glu Ala Gly Ser Val Ala Leu Glu
        195                 200                 205             
Glu Leu Val Glu Lys Glu Lys Asp Arg Phe Phe Ser Gly Val Asp Tyr
    210                 215                 220                 
Ile Val Ile Ser Asp Asn Leu Trp Ile Ser Gln Arg Lys Leu Ala Ile
225                 230                 235                 240 
Thr Tyr Gly Thr Arg Gly Asn Ser Tyr Phe Met Val Glu Val Lys Cys
                245                 250                 255     
Arg Asp Gln Asp Phe His Ser Gly Thr Phe Gly Gly Ile Leu His Glu
            260                 265                 270         
Leu Met Ala Asp Leu Val Ala Leu Leu Gly Ser Leu Val Asp Ser Ser
        275                 280                 285             
Gly His Ile Leu Val Pro Gly Ile Tyr Asp Glu Val Val Pro Leu Thr
    290                 295                 300                 
Glu Glu Glu Ile Asn Thr Tyr Lys Ala Ile His Leu Asp Leu Glu Glu
305                 310                 315                 320 
Tyr Arg Asn Ser Ser Arg Val Glu Lys Phe Leu Phe Asp Thr Lys Glu
                325                 330                 335     
Glu Ile Leu Met His Leu Trp Arg Tyr Pro Ser Leu Ser Ile His Gly
            340                 345                 350         
Ile Glu Gly Ala Phe Asp Glu Pro Gly Thr Lys Thr Val Ile Pro Gly
        355                 360                 365             
Arg Val Ile Gly Lys Phe Ser Ile Arg Leu Val Pro His Met Asn Val
    370                 375                 380                 
Ser Ala Val Glu Lys Gln Val Thr Arg His Leu Glu Asp Val Phe Ser
385                 390                 395                 400 
Lys Arg Asn Ser Ser Asn Lys Met Val Val Ser Met Thr Leu Gly Leu
                405                 410                 415     
His Pro Trp Ile Ala Asn Ile Asp Asp Thr Gln Tyr Leu Ala Ala Lys
            420                 425                 430         
Arg Ala Ile Arg Thr Val Phe Gly Thr Glu Pro Asp Met Ile Arg Asp
        435                 440                 445             
Gly Ser Thr Ile Pro Ile Ala Lys Met Phe Gln Glu Ile Val His Lys
    450                 455                 460                 
Ser Val Val Leu Ile Pro Leu Gly Ala Val Asp Asp Gly Glu His Ser
465                 470                 475                 480 
Gln Asn Glu Lys Ile Asn Arg Trp Asn Tyr Ile Glu Gly Thr Lys Leu
                485                 490                 495     
Phe Ala Ala Phe Phe Leu Glu Met Ala Gln Leu His
            500                 505             


<210> 5528
<211> 127
<212> PRT
<213> Homo sapiens

<400> 5528
Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu
 1               5                  10                  15      
Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln
            20                  25                  30          
Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser
        35                  40                  45              
Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg
    50                  55                  60                  
Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Pro Ser Thr Phe Arg Gly
65                  70                  75                  80  
Phe Met Gln Thr Tyr Tyr Asp Asp His Leu Arg Asp Leu Gly Pro Leu
                85                  90                  95      
Thr Lys Ala Trp Phe Leu Glu Ser Lys Asp Ser Leu Leu Lys Lys Thr
            100                 105                 110         
His Ser Leu Cys Pro Arg Leu Val Cys Gly Asp Lys Asp Gln Gly
        115                 120                 125         


<210> 5529
<211> 760
<212> PRT
<213> Homo sapiens

<400> 5529
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15      
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30          
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45              
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60                  
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80  
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95      
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110         
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125             
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile
    130                 135                 140                 
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160 
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175     
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190         
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205             
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220                 
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240 
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255     
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270         
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285             
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300                 
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320 
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335     
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350         
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365             
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380                 
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400 
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415     
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430         
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445             
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460                 
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480 
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495     
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510         
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525             
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540                 
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560 
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575     
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590         
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605             
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620                 
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640 
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655     
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670         
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685             
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700                 
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720 
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735     
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750         
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760 


<210> 5530
<211> 949
<212> PRT
<213> Homo sapiens

<400> 5530
Met Ile Leu Ser Leu Leu Phe Ser Leu Gly Gly Pro Leu Gly Trp Gly
 1               5                  10                  15      
Leu Leu Gly Ala Trp Ala Gln Ala Ser Ser Thr Ser Leu Ser Asp Leu
            20                  25                  30          
Gln Ser Ser Arg Thr Pro Gly Val Trp Lys Ala Glu Ala Glu Asp Thr
        35                  40                  45              
Ser Lys Asp Pro Val Gly Arg Asn Trp Cys Pro Tyr Pro Met Ser Lys
    50                  55                  60                  
Leu Val Thr Leu Leu Ala Leu Cys Lys Thr Glu Lys Phe Leu Ile His
65                  70                  75                  80  
Ser Gln Gln Pro Cys Pro Gln Gly Ala Pro Asp Cys Gln Lys Val Lys
                85                  90                  95      
Val Met Tyr Arg Met Ala His Lys Pro Val Tyr Gln Val Lys Gln Lys
            100                 105                 110         
Val Leu Thr Ser Leu Ala Trp Arg Cys Cys Pro Gly Tyr Thr Gly Pro
        115                 120                 125             
Asn Cys Glu His His Asp Ser Met Ala Ile Pro Glu Pro Ala Asp Pro
    130                 135                 140                 
Gly Asp Ser His Gln Glu Pro Gln Asp Gly Pro Val Ser Phe Lys Pro
145                 150                 155                 160 
Gly His Leu Ala Ala Val Ile Asn Glu Val Glu Val Gln Gln Glu Gln
                165                 170                 175     
Gln Glu His Leu Leu Gly Asp Leu Gln Asn Asp Val His Arg Val Ala
            180                 185                 190         
Asp Ser Leu Pro Gly Leu Trp Lys Ala Leu Pro Gly Asn Leu Thr Ala
        195                 200                 205             
Ala Val Met Glu Ala Asn Gln Thr Gly His Glu Phe Pro Asp Arg Ser
    210                 215                 220                 
Leu Glu Gln Val Leu Leu Pro His Val Asp Thr Phe Leu Gln Val His
225                 230                 235                 240 
Phe Ser Pro Ile Trp Arg Ser Phe Asn Gln Ser Leu His Ser Leu Thr
                245                 250                 255     
Gln Ala Ile Arg Asn Leu Ser Leu Asp Val Glu Ala Asn Arg Gln Ala
            260                 265                 270         
Ile Ser Arg Val Gln Asp Ser Ala Val Ala Arg Ala Asp Phe Gln Glu
        275                 280                 285             
Leu Gly Ala Lys Phe Glu Ala Lys Val Gln Glu Asn Thr Gln Arg Val
    290                 295                 300                 
Gly Gln Leu Arg Gln Asp Val Glu Asp Arg Leu His Ala Gln His Phe
305                 310                 315                 320 
Thr Leu His Arg Ser Ile Ser Glu Leu Gln Ala Asp Val Asp Thr Lys
                325                 330                 335     
Leu Lys Arg Leu His Lys Ala Gln Glu Ala Pro Gly Thr Asn Gly Ser
            340                 345                 350         
Leu Val Leu Ala Thr Pro Gly Ala Gly Ala Arg Pro Glu Pro Asp Ser
        355                 360                 365             
Leu Gln Ala Arg Leu Gly Gln Leu Gln Arg Asn Leu Ser Glu Leu His
    370                 375                 380                 
Met Thr Thr Ala Arg Arg Glu Glu Glu Leu Gln Tyr Thr Leu Glu Asp
385                 390                 395                 400 
Met Arg Ala Thr Leu Thr Arg His Val Asp Glu Ile Lys Glu Leu Tyr
                405                 410                 415     
Ser Glu Ser Asp Glu Thr Phe Asp Gln Ile Ser Lys Val Glu Arg Gln
            420                 425                 430         
Val Glu Glu Leu Gln Val Asn His Thr Ala Leu Arg Glu Leu Arg Val
        435                 440                 445             
Ile Leu Met Glu Lys Ser Leu Ile Met Glu Glu Asn Lys Glu Glu Val
    450                 455                 460                 
Glu Arg Gln Leu Leu Glu Leu Asn Leu Thr Leu Gln His Leu Gln Gly
465                 470                 475                 480 
Gly His Ala Asp Leu Ile Lys Tyr Val Lys Asp Cys Asn Cys Gln Lys
                485                 490                 495     
Leu Tyr Leu Asp Leu Asp Val Ile Arg Glu Gly Gln Arg Asp Ala Thr
            500                 505                 510         
Arg Ala Leu Glu Glu Thr Gln Val Ser Leu Asp Glu Arg Arg Gln Leu
        515                 520                 525             
Asp Gly Ser Ser Leu Gln Ala Leu Gln Asn Ala Val Asp Ala Val Ser
    530                 535                 540                 
Leu Ala Val Asp Ala His Lys Ala Glu Gly Glu Arg Ala Arg Ala Ala
545                 550                 555                 560 
Thr Ser Arg Leu Arg Ser Gln Val Gln Ala Leu Asp Asp Glu Val Gly
                565                 570                 575     
Ala Leu Lys Ala Ala Ala Ala Glu Ala Arg His Glu Val Arg Gln Leu
            580                 585                 590         
His Ser Ala Phe Ala Ala Leu Leu Glu Asp Ala Leu Arg His Glu Ala
        595                 600                 605             
Val Leu Ala Ala Leu Phe Gly Glu Glu Val Leu Glu Glu Met Ser Glu
    610                 615                 620                 
Gln Thr Pro Gly Pro Leu Pro Leu Ser Tyr Glu Gln Ile Arg Val Ala
625                 630                 635                 640 
Leu Gln Asp Ala Ala Ser Gly Leu Gln Glu Gln Ala Leu Gly Trp Asp
                645                 650                 655     
Glu Leu Ala Ala Arg Val Thr Ala Leu Glu Gln Ala Ser Glu Pro Pro
            660                 665                 670         
Arg Pro Ala Glu His Leu Glu Pro Ser His Asp Ala Gly Arg Glu Glu
        675                 680                 685             
Ala Ala Thr Thr Ala Leu Ala Gly Leu Ala Arg Glu Leu Gln Ser Leu
    690                 695                 700                 
Ser Asn Asp Val Lys Asn Val Gly Arg Cys Cys Glu Ala Glu Ala Gly
705                 710                 715                 720 
Ala Gly Ala Ala Ser Leu Asn Ala Ser Leu Asp Gly Leu His Asn Ala
                725                 730                 735     
Leu Phe Ala Thr Gln Arg Ser Leu Glu Gln His Gln Arg Leu Phe His
            740                 745                 750         
Ser Leu Phe Gly Asn Phe Gln Gly Leu Met Glu Ala Asn Val Ser Leu
        755                 760                 765             
Asp Leu Gly Lys Leu Gln Thr Met Leu Ser Arg Lys Gly Lys Lys Gln
    770                 775                 780                 
Gln Lys Asp Leu Glu Ala Pro Arg Lys Arg Asp Lys Lys Glu Ala Glu
785                 790                 795                 800 
Pro Leu Val Asp Ile Arg Val Thr Gly Pro Val Pro Gly Ala Leu Gly
                805                 810                 815     
Ala Ala Leu Trp Glu Ala Gly Ser Pro Val Ala Phe Tyr Ala Ser Phe
            820                 825                 830         
Ser Glu Gly Thr Ala Ala Leu Gln Thr Val Lys Phe Asn Thr Thr Tyr
        835                 840                 845             
Ile Asn Ile Gly Ser Ser Tyr Phe Pro Glu His Gly Tyr Phe Arg Ala
    850                 855                 860                 
Pro Glu Arg Gly Val Tyr Leu Phe Ala Val Ser Val Glu Phe Gly Pro
865                 870                 875                 880 
Gly Pro Gly Thr Gly Gln Leu Val Phe Gly Gly His His Arg Thr Pro
                885                 890                 895     
Val Cys Thr Thr Gly Gln Gly Ser Gly Ser Thr Ala Thr Val Phe Ala
            900                 905                 910         
Met Ala Glu Leu Gln Lys Gly Glu Arg Val Trp Phe Glu Leu Thr Gln
        915                 920                 925             
Gly Ser Ile Thr Lys Arg Ser Leu Ser Gly Thr Ala Phe Gly Gly Phe
    930                 935                 940                 
Leu Met Phe Lys Thr
945                 


<210> 5531
<211> 1676
<212> PRT
<213> Homo sapiens

<400> 5531
Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr
 1               5                  10                  15      
Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg
            20                  25                  30          
Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu
        35                  40                  45              
Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe
    50                  55                  60                  
Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln
65                  70                  75                  80  
Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln
                85                  90                  95      
Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser
            100                 105                 110         
Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile
        115                 120                 125             
His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg
    130                 135                 140                 
Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val
145                 150                 155                 160 
Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu
                165                 170                 175     
Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser
            180                 185                 190         
Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp
        195                 200                 205             
Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu
    210                 215                 220                 
Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr
225                 230                 235                 240 
Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr
                245                 250                 255     
Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg
            260                 265                 270         
Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln
        275                 280                 285             
Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu
    290                 295                 300                 
Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn
305                 310                 315                 320 
Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe
                325                 330                 335     
Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr
            340                 345                 350         
Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro
        355                 360                 365             
Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly
    370                 375                 380                 
Gly Val Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu
385                 390                 395                 400 
Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly
                405                 410                 415     
Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu
            420                 425                 430         
Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala
        435                 440                 445             
Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr
    450                 455                 460                 
Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu
465                 470                 475                 480 
His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile
                485                 490                 495     
Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe
            500                 505                 510         
Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile
        515                 520                 525             
Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr
    530                 535                 540                 
Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp
545                 550                 555                 560 
Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser
                565                 570                 575     
Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met
            580                 585                 590         
Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala
        595                 600                 605             
Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe
    610                 615                 620                 
Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu
625                 630                 635                 640 
Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn
                645                 650                 655     
Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile
            660                 665                 670         
Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala
        675                 680                 685             
Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys
    690                 695                 700                 
Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu
705                 710                 715                 720 
Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser
                725                 730                 735     
Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu
            740                 745                 750         
His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr
        755                 760                 765             
Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys
    770                 775                 780                 
Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln
785                 790                 795                 800 
Gly Ile Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys
                805                 810                 815     
Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser
            820                 825                 830         
Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr
        835                 840                 845             
Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly
    850                 855                 860                 
Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser
865                 870                 875                 880 
Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val
                885                 890                 895     
Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe
            900                 905                 910         
Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg
        915                 920                 925             
Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu
    930                 935                 940                 
Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro
945                 950                 955                 960 
Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile
                965                 970                 975     
Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu
            980                 985                 990         
Ser Gln Glu Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly Ser Ala
        995                 1000                1005            
Glu Ala Glu Leu Met Ser Val Val Pro Val Phe Tyr Val Phe His Tyr
    1010                1015                1020                
Leu Glu Thr Gly Asn His Trp Asn Ile Phe His Ser Asp Pro Leu Ile
1025                1030                1035                1040
Glu Lys Gln Lys Leu Lys Lys Lys Leu Lys Glu Gly Met Leu Ser Ile
                1045                1050                1055    
Met Ser Tyr Arg Asn Ala Asp Tyr Ser Tyr Ser Val Trp Lys Gly Gly
            1060                1065                1070        
Ser Ala Ser Thr Trp Leu Thr Ala Phe Ala Leu Arg Val Leu Gly Gln
        1075                1080                1085            
Val Asn Lys Tyr Val Glu Gln Asn Gln Asn Ser Ile Cys Asn Ser Leu
    1090                1095                1100                
Leu Trp Leu Val Glu Asn Tyr Gln Leu Asp Asn Gly Ser Phe Lys Glu
1105                1110                1115                1120
Asn Ser Gln Tyr Gln Pro Ile Lys Leu Gln Gly Thr Leu Pro Val Glu
                1125                1130                1135    
Ala Arg Glu Asn Ser Leu Tyr Leu Thr Ala Phe Thr Val Ile Gly Ile
            1140                1145                1150        
Arg Lys Ala Phe Asp Ile Cys Pro Leu Val Lys Ile Asp Thr Ala Leu
        1155                1160                1165            
Ile Lys Ala Asp Asn Phe Leu Leu Glu Asn Thr Leu Pro Ala Gln Ser
    1170                1175                1180                
Thr Phe Thr Leu Ala Ile Ser Ala Tyr Ala Leu Ser Leu Gly Asp Lys
1185                1190                1195                1200
Thr His Pro Gln Phe Arg Ser Ile Val Ser Ala Leu Lys Arg Glu Ala
                1205                1210                1215    
Leu Val Lys Gly Asn Pro Pro Ile Tyr Arg Phe Trp Lys Asp Asn Leu
            1220                1225                1230        
Gln His Lys Asp Ser Ser Val Pro Asn Thr Gly Thr Ala Arg Met Val
        1235                1240                1245            
Glu Thr Thr Ala Tyr Ala Leu Leu Thr Ser Leu Asn Leu Lys Asp Ile
    1250                1255                1260                
Asn Tyr Val Asn Pro Val Ile Lys Trp Leu Ser Glu Glu Gln Arg Tyr
1265                1270                1275                1280
Gly Gly Gly Phe Tyr Ser Thr Gln Asp Thr Ile Asn Ala Ile Glu Gly
                1285                1290                1295    
Leu Thr Glu Tyr Ser Leu Leu Val Lys Gln Leu Arg Leu Ser Met Asp
            1300                1305                1310        
Ile Asp Val Ser Tyr Lys His Lys Gly Ala Leu His Asn Tyr Lys Met
        1315                1320                1325            
Thr Asp Lys Asn Phe Leu Gly Arg Pro Val Glu Val Leu Leu Asn Asp
    1330                1335                1340                
Asp Leu Ile Val Ser Thr Gly Phe Gly Ser Gly Leu Ala Thr Val His
1345                1350                1355                1360
Val Thr Thr Val Val His Lys Thr Ser Thr Ser Glu Glu Val Cys Ser
                1365                1370                1375    
Phe Tyr Leu Lys Ile Asp Thr Gln Asp Ile Glu Ala Ser His Tyr Arg
            1380                1385                1390        
Gly Tyr Gly Asn Ser Asp Tyr Lys Arg Ile Val Ala Cys Ala Ser Tyr
        1395                1400                1405            
Lys Pro Ser Arg Glu Glu Ser Ser Ser Gly Ser Ser His Ala Val Met
    1410                1415                1420                
Asp Ile Ser Leu Pro Thr Gly Ile Ser Ala Asn Glu Glu Asp Leu Lys
1425                1430                1435                1440
Ala Leu Val Glu Gly Val Asp Gln Leu Phe Thr Asp Tyr Gln Ile Lys
                1445                1450                1455    
Asp Gly His Val Ile Leu Gln Leu Asn Ser Ile Pro Ser Ser Asp Phe
            1460                1465                1470        
Leu Cys Val Arg Phe Arg Ile Phe Glu Leu Phe Glu Val Gly Phe Leu
        1475                1480                1485            
Ser Pro Ala Thr Phe Thr Val Tyr Glu Tyr His Arg Pro Asp Lys Gln
    1490                1495                1500                
Cys Thr Met Phe Tyr Ser Thr Ser Asn Ile Lys Ile Gln Lys Val Cys
1505                1510                1515                1520
Glu Gly Ala Ala Cys Lys Cys Val Glu Ala Asp Cys Gly Gln Met Gln
                1525                1530                1535    
Glu Glu Leu Asp Leu Thr Ile Ser Ala Glu Thr Arg Lys Gln Thr Ala
            1540                1545                1550        
Cys Lys Pro Glu Ile Ala Tyr Ala Tyr Lys Val Ser Ile Thr Ser Ile
        1555                1560                1565            
Thr Val Glu Asn Val Phe Val Lys Tyr Lys Ala Thr Leu Leu Asp Ile
    1570                1575                1580                
Tyr Lys Thr Gly Glu Ala Val Ala Glu Lys Asp Ser Glu Ile Thr Phe
1585                1590                1595                1600
Ile Lys Lys Val Thr Cys Thr Asn Ala Glu Leu Val Lys Gly Arg Gln
                1605                1610                1615    
Tyr Leu Ile Met Gly Lys Glu Ala Leu Gln Ile Lys Tyr Asn Phe Ser
            1620                1625                1630        
Phe Arg Tyr Ile Tyr Pro Leu Asp Ser Leu Thr Trp Ile Glu Tyr Trp
        1635                1640                1645            
Pro Arg Asp Thr Thr Cys Ser Ser Cys Gln Ala Phe Leu Ala Asn Leu
    1650                1655                1660                
Asp Glu Phe Ala Glu Asp Ile Phe Leu Asn Gly Cys
1665                1670                1675    


<210> 5532
<211> 676
<212> PRT
<213> Homo sapiens

<400> 5532
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15      
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30          
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45              
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60                  
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80  
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95      
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110         
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125             
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140                 
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160 
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175     
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190         
Thr Asp Arg Ile Pro Ala Thr Ser Thr Ser Ser Asn Thr Ile Ser Ala
        195                 200                 205             
Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu
    210                 215                 220                 
Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser
225                 230                 235                 240 
Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln
                245                 250                 255     
Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu
            260                 265                 270         
Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr Thr Ala
        275                 280                 285             
Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile His His
    290                 295                 300                 
Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr Ile Gln
305                 310                 315                 320 
Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys Glu Gln
                325                 330                 335     
Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro Lys Glu
            340                 345                 350         
Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His Thr Ser
        355                 360                 365             
His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp
    370                 375                 380                 
Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly His Gln
385                 390                 395                 400 
Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln
                405                 410                 415     
Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr
            420                 425                 430         
Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser
        435                 440                 445             
Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser
    450                 455                 460                 
Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp
465                 470                 475                 480 
Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser
                485                 490                 495     
His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser
            500                 505                 510         
Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser
        515                 520                 525             
Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His
    530                 535                 540                 
Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His
545                 550                 555                 560 
Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile
                565                 570                 575     
Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu
            580                 585                 590         
Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg
        595                 600                 605             
Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala
    610                 615                 620                 
Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser
625                 630                 635                 640 
Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp
                645                 650                 655     
Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met
            660                 665                 670         
Lys Ile Gly Val
        675     


<210> 5533
<211> 361
<212> PRT
<213> Homo sapiens

<400> 5533
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15      
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30          
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45              
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60                  
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80  
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95      
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110         
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125             
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140                 
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160 
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175     
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190         
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205             
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp
    210                 215                 220                 
Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser
225                 230                 235                 240 
Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr
                245                 250                 255     
Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile
            260                 265                 270         
Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala
        275                 280                 285             
Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn
    290                 295                 300                 
Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ile Gly Leu Asn Gly
305                 310                 315                 320 
Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser
                325                 330                 335     
Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu
            340                 345                 350         
Gln Asn Val Asp Met Lys Ile Gly Val
        355                 360     


<210> 5534
<211> 742
<212> PRT
<213> Homo sapiens

<400> 5534
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15      
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30          
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45              
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60                  
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly
65                  70                  75                  80  
Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile
                85                  90                  95      
Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser
            100                 105                 110         
Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp
        115                 120                 125             
Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr
    130                 135                 140                 
Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu
145                 150                 155                 160 
Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp
                165                 170                 175     
Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly
            180                 185                 190         
Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp
        195                 200                 205             
Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu
    210                 215                 220                 
Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu
225                 230                 235                 240 
Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn
                245                 250                 255     
His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile
            260                 265                 270         
Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg
        275                 280                 285             
His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile
    290                 295                 300                 
Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln
305                 310                 315                 320 
Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val
                325                 330                 335     
Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr
            340                 345                 350         
Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile
        355                 360                 365             
His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr
    370                 375                 380                 
Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys
385                 390                 395                 400 
Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro
                405                 410                 415     
Arg Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His
            420                 425                 430         
Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser
        435                 440                 445             
Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly
    450                 455                 460                 
His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Thr Thr
465                 470                 475                 480 
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp
                485                 490                 495     
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
            500                 505                 510         
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
        515                 520                 525             
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
    530                 535                 540                 
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
545                 550                 555                 560 
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
                565                 570                 575     
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
            580                 585                 590         
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
        595                 600                 605             
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
    610                 615                 620                 
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
625                 630                 635                 640 
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
                645                 650                 655     
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
            660                 665                 670         
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
        675                 680                 685             
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
    690                 695                 700                 
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
705                 710                 715                 720 
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
                725                 730                 735     
Asp Met Lys Ile Gly Val
            740         


<210> 5535
<211> 470
<212> PRT
<213> Homo sapiens

<400> 5535
Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn
 1               5                  10                  15      
Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala
            20                  25                  30          
Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser
        35                  40                  45              
Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val
    50                  55                  60                  
Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly
65                  70                  75                  80  
Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe
                85                  90                  95      
Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu
            100                 105                 110         
Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp
        115                 120                 125             
Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp
    130                 135                 140                 
Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser
145                 150                 155                 160 
Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser
                165                 170                 175     
Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser
            180                 185                 190         
Thr Asp Arg Ile Pro Ala Thr Asn Met Asp Ser Ser His Ser Ile Thr
        195                 200                 205             
Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp
    210                 215                 220                 
Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser
225                 230                 235                 240 
Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr
                245                 250                 255     
Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg
            260                 265                 270         
Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr
        275                 280                 285             
Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val
    290                 295                 300                 
Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly
305                 310                 315                 320 
Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr
                325                 330                 335     
Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp
            340                 345                 350         
Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly
        355                 360                 365             
Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser
    370                 375                 380                 
Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser
385                 390                 395                 400 
Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn
                405                 410                 415     
Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser
            420                 425                 430         
Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr
        435                 440                 445             
Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val
    450                 455                 460                 
Asp Met Lys Ile Gly Val
465                 470 


<210> 5536
<211> 139
<212> PRT
<213> Homo sapiens

<400> 5536
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro
 1               5                  10                  15      
Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly
            20                  25                  30          
Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu
        35                  40                  45              
Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala
    50                  55                  60                  
Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His
65                  70                  75                  80  
Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp
                85                  90                  95      
Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln
            100                 105                 110         
Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly
        115                 120                 125             
Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser
    130                 135                 


<210> 5537
<211> 461
<212> PRT
<213> Homo sapiens

<400> 5537
Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile
 1               5                  10                  15      
Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg
            20                  25                  30          
Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu
        35                  40                  45              
Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys
    50                  55                  60                  
Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu
65                  70                  75                  80  
Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro
                85                  90                  95      
Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile
            100                 105                 110         
Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly
        115                 120                 125             
Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn
    130                 135                 140                 
Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys
145                 150                 155                 160 
Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His
                165                 170                 175     
Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys
            180                 185                 190         
Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val
        195                 200                 205             
Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro
    210                 215                 220                 
Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala
225                 230                 235                 240 
Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp
                245                 250                 255     
Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg
            260                 265                 270         
Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His
        275                 280                 285             
Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His
    290                 295                 300                 
Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu
305                 310                 315                 320 
Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu
                325                 330                 335     
Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala
            340                 345                 350         
Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val
        355                 360                 365             
Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn
    370                 375                 380                 
Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly
385                 390                 395                 400 
Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu
                405                 410                 415     
Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr
            420                 425                 430         
Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His
        435                 440                 445             
Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro
    450                 455                 460     


<210> 5538
<211> 286
<212> PRT
<213> Homo sapiens

<400> 5538
Ser His Gly Pro Trp Cys Tyr Thr Met Asp Pro Arg Thr Pro Phe Asp
 1               5                  10                  15      
Tyr Cys Ala Leu Arg Arg Cys Ala Asp Asp Gln Pro Pro Ser Ile Leu
            20                  25                  30          
Asp Pro Pro Asp Gln Val Gln Phe Glu Lys Cys Gly Lys Arg Val Asp
        35                  40                  45              
Arg Leu Asp Gln Arg Arg Ser Lys Leu Arg Val Ala Gly Gly His Pro
    50                  55                  60                  
Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn Arg Gln Gly Gln His
65                  70                  75                  80  
Phe Cys Ala Gly Ser Leu Val Lys Glu Gln Trp Ile Leu Thr Ala Arg
                85                  90                  95      
Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr Gly Tyr Glu Val Trp
            100                 105                 110         
Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly Glu Pro Gly Leu Gln
        115                 120                 125             
Arg Val Pro Val Ala Lys Met Leu Cys Gly Pro Ser Gly Ser Gln Leu
    130                 135                 140                 
Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu Asn Gln Arg Val Ala
145                 150                 155                 160 
Leu Ile Cys Leu Pro Pro Glu Trp Tyr Val Val Pro Pro Gly Thr Lys
                165                 170                 175     
Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly Thr Gly Asn Asp Thr
            180                 185                 190         
Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser Asn Gln Glu Cys Asn
        195                 200                 205             
Ile Lys His Arg Gly His Val Arg Glu Ser Glu Met Cys Thr Glu Gly
    210                 215                 220                 
Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp Tyr Gly Gly Pro Leu
225                 230                 235                 240 
Ala Cys Phe Thr His Asn Cys Trp Val Leu Lys Gly Ile Arg Ile Pro
                245                 250                 255     
Asn Arg Val Cys Thr Arg Ser Arg Trp Pro Ala Val Phe Thr Arg Val
            260                 265                 270         
Ser Val Phe Val Asp Trp Ile His Lys Val Met Arg Leu Gly
        275                 280                 285     


<210> 5539
<211> 726
<212> PRT
<213> Homo sapiens

<400> 5539
Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val
 1               5                  10                  15      
Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr
            20                  25                  30          
Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu
        35                  40                  45              
Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met
    50                  55                  60                  
Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu
65                  70                  75                  80  
Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly
                85                  90                  95      
Arg Cys Asp Leu Phe Gln Lys Lys Gly Lys Gly Pro Gln Pro Lys Leu
            100                 105                 110         
Ile Phe Cys Leu Leu Leu Pro Asp Tyr Val Arg Thr Cys Ile Met Asn
        115                 120                 125             
Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly Leu
    130                 135                 140                 
Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr Thr
145                 150                 155                 160 
Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro Asp
                165                 170                 175     
Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val Arg
            180                 185                 190         
Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val Trp
        195                 200                 205             
Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser Gly
    210                 215                 220                 
Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro Phe
225                 230                 235                 240 
Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys Arg
                245                 250                 255     
Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro Gln
            260                 265                 270         
Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala Gln
        275                 280                 285             
Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly Glu
    290                 295                 300                 
Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys Gln
305                 310                 315                 320 
Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu Lys
                325                 330                 335     
Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp Gly
            340                 345                 350         
Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala Ala
        355                 360                 365             
Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln Asp
    370                 375                 380                 
Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys Thr
385                 390                 395                 400 
Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His Lys
                405                 410                 415     
Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu Asn
            420                 425                 430         
Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr Thr
        435                 440                 445             
Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys Ala
    450                 455                 460                 
Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln Phe
465                 470                 475                 480 
Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser Lys
                485                 490                 495     
Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser
            500                 505                 510         
Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys
        515                 520                 525             
Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met
    530                 535                 540                 
Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro
545                 550                 555                 560 
Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val
                565                 570                 575     
Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser
            580                 585                 590         
Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu Trp
        595                 600                 605             
Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu
    610                 615                 620                 
Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn
625                 630                 635                 640 
Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg
                645                 650                 655     
Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys
            660                 665                 670         
Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys Trp
        675                 680                 685             
Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg
    690                 695                 700                 
Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His
705                 710                 715                 720 
Lys Val Met Arg Leu Gly
                725     


<210> 5540
<211> 648
<212> PRT
<213> Homo sapiens

<400> 5540
Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val
 1               5                  10                  15      
Pro Gly Ala Pro Gly His Arg Ala Thr Ala Pro Leu Gln Ala Val Val
            20                  25                  30          
Pro Gly Pro Trp Gln Glu Asp Val Ala Asp Ala Glu Glu Cys Ala Gly
        35                  40                  45              
Arg Cys Gly Pro Leu Met Asp Cys Arg Ala Phe His Tyr Asn Val Ser
    50                  55                  60                  
Ser His Gly Cys Gln Leu Leu Pro Trp Thr Gln His Ser Pro His Thr
65                  70                  75                  80  
Arg Leu Arg His Ser Gly Arg Cys Asp Leu Phe Gln Glu Lys Gly Glu
                85                  90                  95      
Trp Gly Tyr Met Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys
            100                 105                 110         
Arg Asn Pro Asp Gly Asp Pro Gly Gly Pro Trp Cys His Thr Thr Asp
        115                 120                 125             
Pro Ala Val Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Val Ala
    130                 135                 140                 
Ala Cys Val Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg
145                 150                 155                 160 
Thr Glu Ser Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His
                165                 170                 175     
Gln His Pro Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp
            180                 185                 190         
Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr
        195                 200                 205             
Thr Asp Pro Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly
    210                 215                 220                 
Ser Glu Ala Gln Pro Arg Gln Glu Ala Thr Ser Val Ser Cys Phe Arg
225                 230                 235                 240 
Gly Lys Gly Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly
                245                 250                 255     
Val Pro Cys Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe
            260                 265                 270         
Thr Pro Glu Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg
        275                 280                 285             
Asn Pro Asp Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly
    290                 295                 300                 
Met Arg Val Gly Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val
305                 310                 315                 320 
Arg Pro Gln Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr
                325                 330                 335     
Val Ser Lys Thr Arg Lys Gly Val Gln Cys Gln Arg Gly Ala Trp Lys
            340                 345                 350         
Trp Leu Arg Leu Pro Cys His Asp Phe Ala Pro Ala Pro Ala Ser Val
        355                 360                 365             
His Val Tyr Leu Arg Thr Ala Cys Thr Thr Gly Gly Glu Leu Leu Pro
    370                 375                 380                 
Asp Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr Thr Met Asp Pro
385                 390                 395                 400 
Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys Asp Gln Val Gln
                405                 410                 415     
Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Cys Ser
            420                 425                 430         
Lys Leu Arg Val Ala Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val
        435                 440                 445             
Ser Leu Arg Asn Trp Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val
    450                 455                 460                 
Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His
465                 470                 475                 480 
Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn
                485                 490                 495     
Pro Gln His Gly Glu Pro Gly Leu Gln Arg Val Pro Val Ala Lys Met
            500                 505                 510         
Leu Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg
        515                 520                 525             
Tyr Val Asp Asn Leu Gly Gly Trp Thr Lys Cys Glu Ile Ala Gly Arg
    530                 535                 540                 
Gly Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu
545                 550                 555                 560 
Leu Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly His
                565                 570                 575     
Val Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly
            580                 585                 590         
Ala Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn
        595                 600                 605             
Cys Trp Val Leu Lys Gly Ile Arg Ile Pro Asn Arg Val Cys Ala Arg
    610                 615                 620                 
Ser Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp
625                 630                 635                 640 
Ile His Lys Val Met Arg Leu Gly
                645             


<210> 5541
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 5541
Met Gly Glu Asp Asp Ala Ala Leu Arg Ala Gly Ser Arg Gly Leu Ser
 1               5                  10                  15      
Asp Pro Trp Ala Asp Ser Val Gly Val Arg Pro Arg Thr Thr Glu Arg
            20                  25                  30          
His Ile Ala Val His Lys Arg Leu Val Leu Ala Phe Ala Val Ser Leu
        35                  40                  45              
Val Ala Leu Leu Ala Val Thr Met Leu Ala Val Leu Leu Ser Leu Arg
    50                  55                  60                  
Phe Asp Glu Cys Gly Ala Ser Ala Thr Pro Gly Ala Asp Gly Gly Pro
65                  70                  75                  80  
Ser Gly Phe Pro Glu Arg Gly Gly Asn Gly Ser Leu Pro Gly Ser Ala
                85                  90                  95      
Arg Arg Asn His His Ala Gly Gly Asp Ser Trp Gln Pro Glu Ala Gly
            100                 105                 110         
Gly Val Ala Ser Pro Gly Thr Thr Ser Ala Gln Pro Pro Ser Glu Glu
        115                 120                 125             
Glu Arg Glu Pro Trp Glu Pro Trp Thr Gln Leu Arg Leu Ser Gly His
    130                 135                 140                 
Leu Lys Pro Leu His Tyr Asn Leu Met Leu Thr Ala Phe Met Glu Asn
145                 150                 155                 160 
Phe Thr Phe Ser Gly Glu Val Asn Val Glu Ile Ala Cys Arg Asn Ala
                165                 170                 175     
Thr Arg Tyr Val Val Leu His Ala Ser Arg Val Ala Val Glu Lys Val
            180                 185                 190         
Gln Leu Ala Glu Asp Arg Ala Phe Gly Ala Val Pro Val Ala Gly Phe
        195                 200                 205             
Phe Leu Tyr Pro Gln Thr Gln Val Leu Val Val Val Leu Asn Arg Thr
    210                 215                 220                 
Leu Asp Ala Gln Arg Asn Tyr Asn Leu Lys Ile Ile Tyr Asn Ala Leu
225                 230                 235                 240 
Ile Glu Asn Glu Leu Leu Gly Phe Phe Arg Ser Ser Tyr Val Leu His
                245                 250                 255     
Gly Glu Arg Arg Phe Leu Gly Val Thr Gln Phe Ser Pro Thr His Ala
            260                 265                 270         
Arg Lys Ala Phe Pro Cys Phe Asp Glu Pro Ile Tyr Lys Ala Thr Phe
        275                 280                 285             
Lys Ile Ser Ile Lys His Gln Ala Thr Tyr Leu Ser Leu Ser Asn Met
    290                 295                 300                 
Pro Val Glu Thr Ser Val Phe Glu Glu Asp Gly Trp Val Thr Asp His
305                 310                 315                 320 
Phe Ser Gln Thr Pro Leu Met Ser Thr Tyr Tyr Leu Ala Trp Ala Ile
                325                 330                 335     
Cys Asn Phe Thr Tyr Arg Glu Thr Thr Thr Lys Ser Gly Val Val Val
            340                 345                 350         
Arg Leu Tyr Ala Arg Pro Asp Ala Ile Arg Arg Gly Ser Gly Asp Tyr
        355                 360                 365             
Ala Leu His Ile Thr Lys Arg Leu Ile Glu Phe Tyr Glu Asp Tyr Phe
    370                 375                 380                 
Lys Val Pro Tyr Ser Leu Pro Lys Leu Asp Leu Leu Ala Val Pro Lys
385                 390                 395                 400 
His Pro Tyr Ala Ala Met Glu Asn Trp Gly Leu Ser Ile Phe Val Glu
                405                 410                 415     
Gln Arg Ile Leu Leu Asp Pro Ser Val Ser Ser Ile Ser Tyr Leu Leu
            420                 425                 430         
Asp Val Thr Met Val Ile Val His Glu Ile Cys His Gln Trp Phe Gly
        435                 440                 445             
Asp Leu Val Thr Pro Val Trp Trp Glu Asp Val Trp Leu Lys Glu Gly
    450                 455                 460                 
Phe Ala His Tyr Phe Glu Phe Val Gly Thr Asp Tyr Leu Tyr Pro Gly
465                 470                 475                 480 
Trp Asn Met Glu Lys Gln Arg Phe Leu Thr Asp Val Leu His Glu Val
                485                 490                 495     
Met Leu Leu Asp Gly Leu Ala Ser Ser His Pro Val Ser Gln Glu Val
            500                 505                 510         
Leu Gln Ala Thr Asp Ile Asp Arg Val Phe Asp Trp Ile Ala Tyr Lys
        515                 520                 525             
Lys Gly Ala Ala Leu Ile Arg Met Leu Ala Asn Phe Met Gly His Ser
    530                 535                 540                 
Val Phe Gln Arg Gly Leu Gln Asp Tyr Leu Thr Ile His Lys Tyr Gly
545                 550                 555                 560 
Asn Ala Ala Arg Asn Asp Leu Trp Asn Thr Leu Ser Glu Ala Leu Lys
                565                 570                 575     
Arg Asn Gly Lys Tyr Val Asn Ile Gln Glu Val Met Asp Gln Trp Thr
            580                 585                 590         
Leu Gln Met Gly Tyr Pro Val Ile Thr Ile Leu Gly Asn Thr Thr Ala
        595                 600                 605             
Glu Asn Arg Ile Ile Ile Thr Gln Gln His Phe Ile Tyr Asp Ile Ser
    610                 615                 620                 
Ala Lys Thr Lys Ala Leu Lys Leu Gln Asn Asn Ser Tyr Leu Trp Gln
625                 630                 635                 640 
Ile Pro Leu Thr Ile Val Val Gly Asn Arg Ser His Val Ser Ser Glu
                645                 650                 655     
Ala Ile Ile Trp Val Ser Asn Lys Ser Glu His His Arg Ile Thr Tyr
            660                 665                 670         
Leu Asp Lys Gly Ser Trp Leu Leu Gly Asn Ile Asn Gln Thr Gly Tyr
        675                 680                 685             
Phe Arg Val Asn Tyr Asp Leu Arg Asn Trp Arg Leu Leu Ile Asp Gln
    690                 695                 700                 
Leu Ile Arg Asn His Glu Val Leu Ser Val Ser Asn Arg Ala Gly Leu
705                 710                 715                 720 
Ile Asp Asp Ala Phe Ser Leu Ala Arg Ala Gly Tyr Leu Pro Gln Asn
                725                 730                 735     
Ile Pro Leu Glu Ile Ile Arg Tyr Leu Ser Glu Glu Lys Asp Phe Leu
            740                 745                 750         
Pro Trp His Ala Ala Ser Arg Ala Leu Tyr Pro Leu Asp Lys Leu Leu
        755                 760                 765             
Asp Arg Met Glu Asn Tyr Asn Ile Phe Asn Glu Tyr Ile Leu Lys Gln
    770                 775                 780                 
Val Ala Thr Thr Tyr Ile Lys Leu Gly Trp Pro Lys Asn Asn Phe Asn
785                 790                 795                 800 
Gly Ser Leu Val Gln Ala Ser Tyr Gln His Glu Glu Leu Arg Arg Glu
                805                 810                 815     
Val Ile Met Leu Ala Cys Ser Phe Gly Asn Lys His Cys His Gln Gln
            820                 825                 830         
Ala Ser Thr Leu Ile Ser Asp Trp Ile Ser Ser Asn Arg Asn Arg Ile
        835                 840                 845             
Pro Leu Asn Val Arg Asp Ile Val Tyr Cys Thr Gly Val Ser Leu Leu
    850                 855                 860                 
Asp Glu Asp Val Trp Glu Phe Ile Trp Met Lys Phe His Ser Thr Thr
865                 870                 875                 880 
Ala Val Ser Glu Lys Lys Ile Leu Leu Glu Ala Leu Thr Cys Ser Asp
                885                 890                 895     
Asp Arg Asn Leu Leu Asn Arg Leu Leu Asn Leu Ser Leu Asn Ser Glu
            900                 905                 910         
Val Val Leu Asp Gln Asp Ala Ile Asp Val Ile Ile His Val Ala Arg
        915                 920                 925             
Asn Pro His Gly Arg Asp Leu Ala Trp Lys Phe Phe Arg Asp Lys Trp
    930                 935                 940                 
Lys Ile Leu Asn Thr Arg Tyr Gly Glu Ala Leu Phe Met Asn Ser Lys
945                 950                 955                 960 
Leu Ile Ser Gly Val Thr Glu Phe Leu Asn Thr Glu Gly Glu Leu Lys
                965                 970                 975     
Glu Leu Lys Asn Phe Met Lys Asn Tyr Asp Gly Val Ala Ala Ala Ser
            980                 985                 990         
Phe Ser Arg Ala Val Glu Thr Val Glu Ala Asn Val Arg Trp Lys Met
        995                 1000                1005            
Leu Tyr Gln Asp Glu Leu Phe Gln Trp Leu Gly Lys Ala Leu Arg His
    1010                1015                1020                


<210> 5542
<211> 521
<212> PRT
<213> Homo sapiens

<400> 5542
Gly Lys Pro Pro Gly Ser Ala Leu Ala Arg Gly Thr Gly Ala Met Ala
 1               5                  10                  15      
Gln Lys Met Asp Cys Gly Ala Gly Leu Leu Gly Phe Gln Ala Glu Ala
            20                  25                  30          
Ser Val Glu Asp Ser Ala Leu Leu Met Gln Thr Leu Met Glu Ala Ile
        35                  40                  45              
Gln Ile Ser Glu Ala Pro Pro Thr Asn Gln Ala Thr Ala Ala Ala Ser
    50                  55                  60                  
Pro Gln Ser Ser Gln Pro Pro Thr Ala Asn Glu Met Ala Asp Ile Gln
65                  70                  75                  80  
Val Ser Ala Ala Ala Ala Arg Pro Lys Ser Ala Phe Lys Val Gln Asn
                85                  90                  95      
Ala Thr Thr Lys Gly Pro Asn Gly Val Tyr Asp Phe Ser Gln Ala His
            100                 105                 110         
Asn Ala Lys Asp Val Pro Asn Thr Gln Pro Lys Ala Ala Phe Lys Ser
        115                 120                 125             
Gln Asn Ala Thr Pro Lys Gly Pro Asn Ala Ala Tyr Asp Phe Ser Gln
    130                 135                 140                 
Ala Ala Thr Thr Gly Glu Leu Ala Ala Asn Lys Ser Glu Met Ala Phe
145                 150                 155                 160 
Lys Ala Gln Asn Ala Thr Thr Lys Val Gly Pro Asn Ala Thr Tyr Asn
                165                 170                 175     
Phe Ser Gln Ser Leu Asn Ala Asn Asp Leu Ala Asn Ser Arg Pro Lys
            180                 185                 190         
Thr Pro Phe Lys Ala Trp Asn Asp Thr Thr Lys Ala Pro Thr Ala Asp
        195                 200                 205             
Thr Gln Thr Gln Asn Val Asn Gln Ala Lys Met Ala Thr Ser Gln Ala
    210                 215                 220                 
Asp Ile Glu Thr Asp Pro Gly Ile Ser Glu Pro Asp Gly Ala Thr Ala
225                 230                 235                 240 
Gln Thr Ser Ala Asp Gly Ser Gln Ala Gln Asn Leu Glu Ser Arg Thr
                245                 250                 255     
Ile Ile Arg Gly Lys Arg Thr Arg Lys Ile Asn Asn Leu Asn Val Glu
            260                 265                 270         
Glu Asn Ser Ser Gly Asp Gln Arg Arg Ala Pro Leu Ala Ala Gly Thr
        275                 280                 285             
Trp Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro Gly Ala
    290                 295                 300                 
Pro Pro Asn Val Ser Gly Arg Arg His Trp Leu Gly Arg Thr Pro Gln
305                 310                 315                 320 
Gly Trp Gln Asn Gln Thr Ala Arg Gln Thr Gln Gln His Val Arg Ala
                325                 330                 335     
Leu Gln Leu Gly Arg Thr Gln Pro Ala Trp Gln Asn Pro Val Ala Trp
            340                 345                 350         
Gln Asn Pro Val Ile Trp Pro Asn Pro Val Ile Trp Gln Asn Pro Val
        355                 360                 365             
Ile Trp Pro Asn Pro Ile Val Trp Pro Gly Pro Val Val Trp Pro Asn
    370                 375                 380                 
Pro Leu Ala Trp Gln Asn Pro Pro Gly Trp Gln Thr Pro Pro Gly Trp
385                 390                 395                 400 
Gln Thr Pro Pro Gly Trp Gln Gly Pro Pro Asp Trp Gln Gly Pro Pro
                405                 410                 415     
Asp Trp Pro Leu Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp Pro Leu
            420                 425                 430         
Pro Thr Asp Trp Pro Leu Pro Pro Asp Trp Ile Pro Ala Asp Trp Pro
        435                 440                 445             
Ile Pro Pro Asp Trp Gln Asn Leu Arg Pro Ser Pro Asn Leu Arg Pro
    450                 455                 460                 
Ser Pro Asn Ser Arg Ala Ser Gln Asn Pro Gly Ala Ala Gln Pro Arg
465                 470                 475                 480 
Asp Val Ala Leu Leu Gln Glu Arg Val Arg Ala Val Thr Pro Gln Ser
                485                 490                 495     
Leu Phe Pro Ser Leu Ala Leu Phe Phe Val Ile Leu Ser Ser Val Ile
            500                 505                 510         
Gln Pro Ser Phe Phe Val Asn Ile Leu
        515                 520     


<210> 5543
<211> 602
<212> PRT
<213> Homo sapiens

<400> 5543
Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe
 1               5                  10                  15      
Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile
            20                  25                  30          
Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val
        35                  40                  45              
Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro
    50                  55                  60                  
Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp
65                  70                  75                  80  
Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn
                85                  90                  95      
Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro
            100                 105                 110         
Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro
        115                 120                 125             
Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly
    130                 135                 140                 
Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe
145                 150                 155                 160 
Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val
                165                 170                 175     
Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly
            180                 185                 190         
Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys
        195                 200                 205             
Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly
    210                 215                 220                 
Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly
225                 230                 235                 240 
Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn
                245                 250                 255     
Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu
            260                 265                 270         
Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile
        275                 280                 285             
Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu
    290                 295                 300                 
Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro
305                 310                 315                 320 
Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu
                325                 330                 335     
Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp
            340                 345                 350         
Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp
        355                 360                 365             
Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile
    370                 375                 380                 
Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His
385                 390                 395                 400 
Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala
                405                 410                 415     
Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu
            420                 425                 430         
Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr
        435                 440                 445             
Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val
    450                 455                 460                 
Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg
465                 470                 475                 480 
Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val
                485                 490                 495     
Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln
            500                 505                 510         
Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr
        515                 520                 525             
Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala
    530                 535                 540                 
Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met
545                 550                 555                 560 
Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His
                565                 570                 575     
Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr
            580                 585                 590         
Thr Ser Lys Lys Glu Ser Cys Val Gly Leu
        595                 600         


<210> 5544
<211> 683
<212> PRT
<213> Homo sapiens

<400> 5544
Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu
 1               5                  10                  15      
Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu
            20                  25                  30          
Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys
        35                  40                  45              
Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val
    50                  55                  60                  
Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr
65                  70                  75                  80  
Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly
                85                  90                  95      
Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys
            100                 105                 110         
Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr
        115                 120                 125             
Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys
    130                 135                 140                 
Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu
145                 150                 155                 160 
Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu
                165                 170                 175     
Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp
            180                 185                 190         
Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu
        195                 200                 205             
Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser
    210                 215                 220                 
His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe
225                 230                 235                 240 
Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu
                245                 250                 255     
Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn
            260                 265                 270         
Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys
        275                 280                 285             
Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly
    290                 295                 300                 
Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro
305                 310                 315                 320 
Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys
                325                 330                 335     
Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr
            340                 345                 350         
Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly
        355                 360                 365             
Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys
    370                 375                 380                 
Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val
385                 390                 395                 400 
Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu
                405                 410                 415     
Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu
            420                 425                 430         
Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser
        435                 440                 445             
Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr
    450                 455                 460                 
Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu
465                 470                 475                 480 
Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr
                485                 490                 495     
Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser
            500                 505                 510         
Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu
        515                 520                 525             
Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn
    530                 535                 540                 
Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr
545                 550                 555                 560 
Arg Arg Ser Ala Ala Thr Arg Cys Glu Arg Leu Pro Cys His Glu Asn
                565                 570                 575     
Arg Glu Cys Ser Lys Leu Pro Leu Arg Ile Thr Tyr Tyr His Leu Ser
            580                 585                 590         
Phe Pro Thr Asn Ile Gln Ala Pro Ala Val Val Phe Arg Met Gly Pro
        595                 600                 605             
Ser Ser Ala Val Pro Gly Asp Ser Met Gln Leu Ala Ile Thr Gly Gly
    610                 615                 620                 
Asn Glu Glu Gly Phe Phe Thr Thr Arg Lys Val Ser Pro His Ser Gly
625                 630                 635                 640 
Val Val Ala Leu Thr Lys Pro Val Pro Glu Pro Arg Asp Leu Leu Leu
                645                 650                 655     
Thr Val Lys Met Asp Leu Ser Arg His Gly Thr Val Ser Ser Phe Val
            660                 665                 670         
Ala Lys Leu Phe Ile Phe Val Ser Ala Glu Leu
        675                 680             


<210> 5545
<211> 703
<212> PRT
<213> Homo sapiens

<400> 5545
Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu
 1               5                  10                  15      
Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu
            20                  25                  30          
Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys
        35                  40                  45              
Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val
    50                  55                  60                  
Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr
65                  70                  75                  80  
Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly
                85                  90                  95      
Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys
            100                 105                 110         
Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr
        115                 120                 125             
Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys
    130                 135                 140                 
Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu
145                 150                 155                 160 
Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu
                165                 170                 175     
Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp
            180                 185                 190         
Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu
        195                 200                 205             
Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser
    210                 215                 220                 
His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe
225                 230                 235                 240 
Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu
                245                 250                 255     
Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn
            260                 265                 270         
Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys
        275                 280                 285             
Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly
    290                 295                 300                 
Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro
305                 310                 315                 320 
Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys
                325                 330                 335     
Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr
            340                 345                 350         
Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly
        355                 360                 365             
Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys
    370                 375                 380                 
Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val
385                 390                 395                 400 
Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu
                405                 410                 415     
Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu
            420                 425                 430         
Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser
        435                 440                 445             
Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr
    450                 455                 460                 
Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu
465                 470                 475                 480 
Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr
                485                 490                 495     
Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser
            500                 505                 510         
Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu
        515                 520                 525             
Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn
    530                 535                 540                 
Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr
545                 550                 555                 560 
Arg Arg Ser Ala Ala Thr Leu Gln Gln Glu Lys Thr Asp Thr Val Arg
                565                 570                 575     
Cys Ile Lys Ser Cys Arg Pro Asn Asp Val Thr Cys Val Phe Asp Pro
            580                 585                 590         
Val His Thr Ile Ser His Thr Val Ile Ser Leu Pro Thr Phe Arg Glu
        595                 600                 605             
Phe Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro
    610                 615                 620                 
His Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn
625                 630                 635                 640 
Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr
                645                 650                 655     
Val Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala
            660                 665                 670         
Val Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His
        675                 680                 685             
Arg Asn Val Val Asn Val Arg Ile Phe Val Ser Glu Tyr Trp Phe
    690                 695                 700             


<210> 5546
<211> 566
<212> PRT
<213> Homo sapiens

<400> 5546
Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu
 1               5                  10                  15      
Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu
            20                  25                  30          
Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys
        35                  40                  45              
Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val
    50                  55                  60                  
Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr
65                  70                  75                  80  
Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly
                85                  90                  95      
Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys
            100                 105                 110         
Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr
        115                 120                 125             
Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys
    130                 135                 140                 
Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu
145                 150                 155                 160 
Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu
                165                 170                 175     
Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp
            180                 185                 190         
Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu
        195                 200                 205             
Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser
    210                 215                 220                 
His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe
225                 230                 235                 240 
Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu
                245                 250                 255     
Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn
            260                 265                 270         
Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys
        275                 280                 285             
Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly
    290                 295                 300                 
Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro
305                 310                 315                 320 
Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys
                325                 330                 335     
Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr
            340                 345                 350         
Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly
        355                 360                 365             
Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys
    370                 375                 380                 
Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val
385                 390                 395                 400 
Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu
                405                 410                 415     
Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu
            420                 425                 430         
Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser
        435                 440                 445             
Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr
    450                 455                 460                 
Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu
465                 470                 475                 480 
Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr
                485                 490                 495     
Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser
            500                 505                 510         
Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu
        515                 520                 525             
Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn
    530                 535                 540                 
Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr
545                 550                 555                 560 
Arg Arg Ser Ala Ala Thr
                565     


<210> 5547
<211> 703
<212> PRT
<213> Homo sapiens

<400> 5547
Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu
 1               5                  10                  15      
Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu
            20                  25                  30          
Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys
        35                  40                  45              
Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val
    50                  55                  60                  
Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr
65                  70                  75                  80  
Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly
                85                  90                  95      
Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys
            100                 105                 110         
Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr
        115                 120                 125             
Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys
    130                 135                 140                 
Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu
145                 150                 155                 160 
Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu
                165                 170                 175     
Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp
            180                 185                 190         
Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu
        195                 200                 205             
Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser
    210                 215                 220                 
His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe
225                 230                 235                 240 
Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu
                245                 250                 255     
Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn
            260                 265                 270         
Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys
        275                 280                 285             
Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly
    290                 295                 300                 
Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro
305                 310                 315                 320 
Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys
                325                 330                 335     
Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr
            340                 345                 350         
Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly
        355                 360                 365             
Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys
    370                 375                 380                 
Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val
385                 390                 395                 400 
Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu
                405                 410                 415     
Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu
            420                 425                 430         
Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser
        435                 440                 445             
Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr
    450                 455                 460                 
Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu
465                 470                 475                 480 
Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr
                485                 490                 495     
Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser
            500                 505                 510         
Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu
        515                 520                 525             
Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn
    530                 535                 540                 
Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr
545                 550                 555                 560 
Arg Arg Ser Ala Ala Thr Gln Lys Ser Lys Lys Gly Arg Gln Asn Thr
                565                 570                 575     
Pro Ala Gly Ser Ser Lys Glu Asp Cys Arg Val Leu Pro Trp Lys Gln
            580                 585                 590         
Gly Leu Glu Asp Thr His Leu Asp Ala Ser Leu Pro Thr Phe Arg Glu
        595                 600                 605             
Phe Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro
    610                 615                 620                 
His Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn
625                 630                 635                 640 
Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr
                645                 650                 655     
Val Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala
            660                 665                 670         
Val Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His
        675                 680                 685             
Arg Asn Val Val Asn Val Arg Ile Phe Val Ser Glu Tyr Trp Phe
    690                 695                 700             


<210> 5548
<211> 535
<212> PRT
<213> Homo sapiens

<400> 5548
Gly Pro Cys Lys Gln Gln Cys Arg Asp Thr Gly Asp Glu Val Val Cys
 1               5                  10                  15      
Ser Cys Phe Val Gly Tyr Gln Leu Leu Ser Asp Gly Val Ser Cys Glu
            20                  25                  30          
Gly Glu Arg Asn His Cys Phe Arg Leu Arg Ala Val His Ser Pro Asp
        35                  40                  45              
Val His Met Val Asp Leu Ser Ser Asp Gly Ser Phe Leu Leu Val Thr
    50                  55                  60                  
Pro Ala Leu Pro Arg Ser Leu Leu Asp Val Asn Glu Cys Ile Thr Gly
65                  70                  75                  80  
Ser His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser
                85                  90                  95      
Phe Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr
            100                 105                 110         
Glu Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His
        115                 120                 125             
Asn Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg
    130                 135                 140                 
Cys Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu
145                 150                 155                 160 
Gly Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys
                165                 170                 175     
Pro Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln
            180                 185                 190         
Lys Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly
        195                 200                 205             
Thr Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys
    210                 215                 220                 
Gly Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu
225                 230                 235                 240 
Cys Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp
                245                 250                 255     
Val Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys
            260                 265                 270         
Glu Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg
        275                 280                 285             
Leu Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser
    290                 295                 300                 
Ser Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys
305                 310                 315                 320 
Tyr Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys
                325                 330                 335     
Glu Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser
            340                 345                 350         
Tyr Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser
        355                 360                 365             
Ser Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp
    370                 375                 380                 
Glu Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe
385                 390                 395                 400 
Asn Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn
                405                 410                 415     
Tyr Arg Arg Ser Ala Ala Thr Arg Cys Glu Arg Leu Pro Cys His Glu
            420                 425                 430         
Asn Arg Glu Cys Ser Lys Leu Pro Leu Arg Ile Thr Tyr Tyr His Leu
        435                 440                 445             
Ser Phe Pro Thr Asn Ile Gln Ala Pro Ala Val Val Phe Arg Met Gly
    450                 455                 460                 
Pro Ser Ser Ala Val Pro Gly Asp Ser Met Gln Leu Ala Ile Thr Gly
465                 470                 475                 480 
Gly Asn Glu Glu Gly Phe Phe Thr Thr Arg Lys Val Ser Pro His Ser
                485                 490                 495     
Gly Val Val Ala Leu Thr Lys Pro Val Pro Glu Pro Arg Asp Leu Leu
            500                 505                 510         
Leu Thr Val Lys Met Asp Leu Ser Arg His Gly Thr Val Ser Ser Phe
        515                 520                 525             
Val Ala Lys Leu Phe Ile Phe
    530                 535 


<210> 5549
<211> 638
<212> PRT
<213> Homo sapiens

<400> 5549
Met Ser Ser Trp Arg Pro Ala Val Arg Thr Asp Thr Gly Trp Pro Leu
 1               5                  10                  15      
Ile Arg Arg Thr Ala Arg Cys His Met Leu Arg Asn Pro Lys Asn Ala
            20                  25                  30          
Gly Trp Cys Arg Ser Ser Ala Ala Thr Ala Ser Trp Arg Ser Cys Thr
        35                  40                  45              
Val Pro Arg Ala Ser Ala Trp Pro Thr Ser Arg Thr Ala Val Pro Arg
    50                  55                  60                  
Pro Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys Val
65                  70                  75                  80  
Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu Thr
                85                  90                  95      
Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu Asn
            100                 105                 110         
Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp Thr
        115                 120                 125             
Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu Ser
    130                 135                 140                 
Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser His
145                 150                 155                 160 
Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe Arg
                165                 170                 175     
Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu Asp
            180                 185                 190         
Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn Cys
        195                 200                 205             
Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys Arg
    210                 215                 220                 
Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly Asn
225                 230                 235                 240 
Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro Ile
                245                 250                 255     
Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys Asn
            260                 265                 270         
Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr Arg
        275                 280                 285             
Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly Lys
    290                 295                 300                 
Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys Lys
305                 310                 315                 320 
Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val Asn
                325                 330                 335     
Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu Asn
            340                 345                 350         
Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu Ser
        355                 360                 365             
Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser Pro
    370                 375                 380                 
Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr Cys
385                 390                 395                 400 
Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu Asp
                405                 410                 415     
Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr Arg
            420                 425                 430         
Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser Gly
        435                 440                 445             
Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu Cys
    450                 455                 460                 
Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn Ile
465                 470                 475                 480 
Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr Arg
                485                 490                 495     
Arg Ser Ala Ala Thr Leu Gln Gln Glu Lys Thr Asp Thr Val Arg Cys
            500                 505                 510         
Ile Lys Ser Cys Arg Pro Asn Asp Val Thr Cys Val Phe Asp Pro Val
        515                 520                 525             
His Thr Ile Ser His Thr Val Ile Ser Leu Pro Thr Phe Arg Glu Phe
    530                 535                 540                 
Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro His
545                 550                 555                 560 
Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn Leu
                565                 570                 575     
Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr Val
            580                 585                 590         
Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala Val
        595                 600                 605             
Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His Arg
    610                 615                 620                 
Asn Val Val Asn Val His Ile Phe Val Ser Glu Tyr Trp Phe
625                 630                 635             


<210> 5550
<211> 449
<212> PRT
<213> Homo sapiens

<400> 5550
Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys
 1               5                  10                  15      
Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile
            20                  25                  30          
Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala
        35                  40                  45              
Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met
    50                  55                  60                  
Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys
65                  70                  75                  80  
Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe
                85                  90                  95      
Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr
            100                 105                 110         
Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu
        115                 120                 125             
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val
    130                 135                 140                 
Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser
145                 150                 155                 160 
Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe
                165                 170                 175     
Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys
            180                 185                 190         
Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile
        195                 200                 205             
Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys
    210                 215                 220                 
Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly
225                 230                 235                 240 
Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp
                245                 250                 255     
Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile
            260                 265                 270         
Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp
        275                 280                 285             
Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly
    290                 295                 300                 
Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys
305                 310                 315                 320 
Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr
                325                 330                 335     
His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr
            340                 345                 350         
Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr
        355                 360                 365             
Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro
    370                 375                 380                 
Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln
385                 390                 395                 400 
Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys
                405                 410                 415     
His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met
            420                 425                 430         
Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr
        435                 440                 445             
Leu
    


<210> 5551
<211> 603
<212> PRT
<213> Homo sapiens

<400> 5551
Met Arg Glu Ala Ala Phe Met Tyr Ser Thr Ala Val Ala Ile Phe Leu
 1               5                  10                  15      
Val Ile Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro
            20                  25                  30          
Leu Pro Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser
        35                  40                  45              
Trp Asn Val Ser Tyr Thr Gln Glu Ala Ile His Phe Gln Leu Leu Val
    50                  55                  60                  
Arg Arg Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu
65                  70                  75                  80  
Leu Glu Asn Ala Asp Leu Val Val Leu Trp Thr Asp Gly Asp Thr Ala
                85                  90                  95      
Tyr Phe Ala Asp Ala Trp Ser Asp Gln Lys Gly Gln Ile His Leu Asp
            100                 105                 110         
Pro Gln Gln Asp Tyr Gln Leu Leu Gln Val Gln Arg Thr Pro Glu Gly
        115                 120                 125             
Leu Thr Leu Leu Phe Lys Arg Pro Phe Gly Thr Cys Asp Pro Lys Asp
    130                 135                 140                 
Tyr Leu Ile Glu Asp Gly Thr Val His Leu Val Tyr Gly Ile Leu Glu
145                 150                 155                 160 
Glu Pro Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met
                165                 170                 175     
Gly Leu Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu
            180                 185                 190         
Leu Pro Ser Asp Ala Cys Thr Met Glu Val Gln Ala Pro Asn Ile Gln
        195                 200                 205             
Ile Pro Ser Gln Glu Thr Thr Tyr Trp Cys Tyr Ile Lys Glu Leu Pro
    210                 215                 220                 
Lys Gly Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Thr
225                 230                 235                 240 
Lys Gly Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala
                245                 250                 255     
Pro Glu Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys
            260                 265                 270         
Met Lys Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp
        275                 280                 285             
Ala Leu Gly Ala Lys Ala Phe Tyr Tyr Pro Glu Glu Ala Gly Leu Ala
    290                 295                 300                 
Phe Gly Gly Pro Gly Ser Ser Arg Tyr Leu Arg Leu Glu Val His Tyr
305                 310                 315                 320 
His Asn Pro Leu Val Ile Glu Gly Arg Asn Asp Ser Ser Gly Ile Arg
                325                 330                 335     
Leu Tyr Tyr Thr Ala Lys Leu Arg Arg Phe Asn Ala Gly Ile Met Glu
            340                 345                 350         
Leu Gly Leu Val Tyr Thr Pro Val Met Ala Ile Pro Pro Arg Glu Thr
        355                 360                 365             
Ala Phe Ile Leu Thr Gly Tyr Cys Thr Asp Lys Cys Thr Gln Leu Ala
    370                 375                 380                 
Leu Pro Pro Ser Gly Ile His Ile Phe Ala Ser Gln Leu His Thr His
385                 390                 395                 400 
Leu Thr Gly Arg Lys Val Val Thr Val Leu Val Arg Asp Gly Arg Glu
                405                 410                 415     
Trp Glu Ile Val Asn Gln Asp Asn His Tyr Ser Pro His Phe Gln Glu
            420                 425                 430         
Ile Arg Met Leu Lys Lys Val Val Ser Val His Pro Gly Asp Val Leu
        435                 440                 445             
Ile Thr Ser Cys Thr Tyr Asn Thr Glu Asp Arg Glu Leu Ala Thr Val
    450                 455                 460                 
Gly Gly Phe Gly Ile Leu Glu Glu Met Cys Val Asn Tyr Val His Tyr
465                 470                 475                 480 
Tyr Pro Gln Thr Gln Leu Glu Leu Cys Lys Thr Ala Val Asp Ala Gly
                485                 490                 495     
Phe Leu Gln Lys Tyr Phe His Leu Ile Asn Arg Phe Asn Asn Glu Asp
            500                 505                 510         
Val Cys Thr Cys Pro Gln Ala Ser Val Ser Gln Gln Phe Thr Ser Val
        515                 520                 525             
Pro Trp Asn Ser Phe Asn Arg Asp Val Leu Lys Ala Leu Tyr Ser Phe
    530                 535                 540                 
Ala Pro Ile Ser Met His Cys Asn Lys Ser Ser Ala Val Arg Phe Gln
545                 550                 555                 560 
Gly Glu Trp Asn Leu Gln Pro Leu Pro Lys Val Ile Ser Thr Leu Glu
                565                 570                 575     
Glu Pro Thr Pro Gln Cys Pro Thr Ser Gln Gly Arg Ser Pro Ala Gly
            580                 585                 590         
Pro Thr Val Val Ser Ile Gly Gly Gly Lys Gly
        595                 600             


<210> 5552
<211> 469
<212> PRT
<213> Homo sapiens

<400> 5552
Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu
 1               5                  10                  15      
Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys
            20                  25                  30          
Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly
        35                  40                  45              
Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr
    50                  55                  60                  
Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp
65                  70                  75                  80  
Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly
                85                  90                  95      
Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser
            100                 105                 110         
Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu
        115                 120                 125             
Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro
    130                 135                 140                 
Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg
145                 150                 155                 160 
Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly
                165                 170                 175     
Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr
            180                 185                 190         
His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser
        195                 200                 205             
Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys
    210                 215                 220                 
Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly
225                 230                 235                 240 
Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val
                245                 250                 255     
Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr
            260                 265                 270         
Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val
        275                 280                 285             
Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His
    290                 295                 300                 
Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser
305                 310                 315                 320 
Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser
                325                 330                 335     
Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly
            340                 345                 350         
Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg
        355                 360                 365             
His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu
    370                 375                 380                 
Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr
385                 390                 395                 400 
Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro
                405                 410                 415     
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp
            420                 425                 430         
Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val
        435                 440                 445             
Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro
    450                 455                 460                 
Glu Glu Glu Glu Leu
465                 


<210> 5553
<211> 322
<212> PRT
<213> Homo sapiens

<400> 5553
Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr
 1               5                  10                  15      
Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile
            20                  25                  30          
Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala
        35                  40                  45              
Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu
    50                  55                  60                  
Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala
65                  70                  75                  80  
Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val
                85                  90                  95      
Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly
            100                 105                 110         
Val Leu Ile Arg Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys
        115                 120                 125             
Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile
    130                 135                 140                 
Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr
145                 150                 155                 160 
Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser
                165                 170                 175     
Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser
            180                 185                 190         
Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu
        195                 200                 205             
Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala
    210                 215                 220                 
Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu
225                 230                 235                 240 
Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe
                245                 250                 255     
Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn
            260                 265                 270         
Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala
        275                 280                 285             
Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro
    290                 295                 300                 
Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala
305                 310                 315                 320 
Glu Val
        


<210> 5554
<211> 322
<212> PRT
<213> Homo sapiens

<400> 5554
Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr
 1               5                  10                  15      
Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile
            20                  25                  30          
Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala
        35                  40                  45              
Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu
    50                  55                  60                  
Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Asp Thr Ala Leu Lys Ala
65                  70                  75                  80  
Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val
                85                  90                  95      
Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly
            100                 105                 110         
Val Leu Ile Trp Lys Val Pro Val Ser Arg Gln Phe Gly Ala Tyr Cys
        115                 120                 125             
Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Arg Ile Pro Glu Ile Ile
    130                 135                 140                 
Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr
145                 150                 155                 160 
Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser
                165                 170                 175     
Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser
            180                 185                 190         
Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu
        195                 200                 205             
Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala
    210                 215                 220                 
Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu
225                 230                 235                 240 
Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe
                245                 250                 255     
Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn
            260                 265                 270         
Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala
        275                 280                 285             
Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro
    290                 295                 300                 
Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala
305                 310                 315                 320 
Glu Val
        


<210> 5555
<211> 1079
<212> PRT
<213> Homo sapiens

<400> 5555
Met Leu Trp Pro Arg Asn Leu Thr Ser Trp Asp Asp Ser Ser Ser Val
 1               5                  10                  15      
Ser Ser Gly Ile Ser Asp Thr Ile Asp Asn Leu Ser Thr Asp Asp Ile
            20                  25                  30          
Asn Thr Ser Ser Ser Ile Ser Ser Tyr Ala Asn Thr Pro Ala Ser Ser
        35                  40                  45              
Arg Lys Asn Leu Asp Val Gln Thr Asp Ala Glu Lys His Ser Gln Val
    50                  55                  60                  
Glu Arg Asn Ser Leu Trp Ser Gly Asp Asp Val Lys Lys Ser Asp Gly
65                  70                  75                  80  
Gly Ser Asp Ser Gly Ile Lys Met Glu Pro Gly Ser Lys Trp Arg Arg
                85                  90                  95      
Asn Pro Ser Asp Val Ser Asp Asp Ser Asp Lys Ser Met Ser Gly Lys
            100                 105                 110         
Lys Asn Pro Val Ile Ser Gln Thr Gly Ser Trp Arg Arg Gly Met Thr
        115                 120                 125             
Ala Gln Val Gly Ile Thr Met Pro Arg Thr Lys Ala Ser Ala Pro Ala
    130                 135                 140                 
Gly Ala Leu Lys Thr Pro Gly Thr Gly Lys Thr Asp Asp Ala Lys Val
145                 150                 155                 160 
Ser Glu Lys Gly Arg Leu Ser Pro Lys Ala Ser Gln Val Lys Arg Ser
                165                 170                 175     
Pro Ser Asp Ala Gly Arg Ser Ser Gly Asp Glu Ser Lys Lys Pro Leu
            180                 185                 190         
Pro Ser Ser Ser Arg Thr Pro Thr Ala Asn Ala Asn Ser Phe Gly Phe
        195                 200                 205             
Lys Lys Gln Ser Gly Ser Ala Ala Gly Leu Ala Met Ile Thr Ala Ser
    210                 215                 220                 
Gly Val Thr Val Thr Ser Arg Ser Ala Thr Leu Asp Lys Ile Pro Lys
225                 230                 235                 240 
Ser Ser Ala Leu Val Ser Arg Ser Ala Gly Arg Lys Ser Ser Met Asp
                245                 250                 255     
Gly Ala Gln Asn Gln Asp Asp Gly Tyr Leu Ala Leu Ser Ser Arg Thr
            260                 265                 270         
Asn Leu Gln Tyr Arg Ser Leu Pro Arg Pro Ser Lys Ser Asn Ser Arg
        275                 280                 285             
Asn Gly Ala Gly Asn Arg Ser Ser Thr Ser Ser Ile Asp Ser Asn Ile
    290                 295                 300                 
Ser Ser Lys Ser Ala Gly Leu Pro Val Pro Lys Leu Arg Glu Pro Ser
305                 310                 315                 320 
Lys Thr Ala Leu Gly Ser Ser Leu Pro Gly Leu Val Asn Gln Thr Asp
                325                 330                 335     
Lys Glu Lys Gly Ile Ser Ser Asp Asn Glu Ser Val Ala Ser Cys Asn
            340                 345                 350         
Ser Val Lys Val Asn Pro Ala Ala Gln Pro Val Ser Ser Pro Ala Gln
        355                 360                 365             
Thr Ser Leu Gln Pro Gly Ala Lys Tyr Pro Asp Val Ala Ser Pro Thr
    370                 375                 380                 
Leu Arg Arg Leu Phe Gly Gly Lys Pro Thr Lys Gln Val Pro Ile Ala
385                 390                 395                 400 
Thr Ala Glu Asn Met Lys Asn Ser Val Val Ile Ser Asn Pro His Ala
                405                 410                 415     
Thr Met Thr Gln Gln Gly Asn Leu Asp Ser Pro Ser Gly Ser Gly Val
            420                 425                 430         
Leu Ser Ser Gly Ser Ser Ser Pro Leu Tyr Ser Lys Asn Val Asp Leu
        435                 440                 445             
Asn Gln Ser Pro Leu Ala Ser Ser Pro Ser Ser Ala His Ser Ala Pro
    450                 455                 460                 
Ser Asn Ser Leu Thr Trp Gly Thr Asn Ala Ser Ser Ser Ser Ala Val
465                 470                 475                 480 
Ser Lys Asp Gly Leu Gly Phe Gln Ser Val Ser Ser Leu His Thr Ser
                485                 490                 495     
Cys Glu Ser Ile Asp Ile Ser Leu Ser Ser Gly Gly Val Pro Ser His
            500                 505                 510         
Asn Ser Ser Thr Gly Leu Ile Ala Ser Ser Lys Asp Asp Ser Leu Thr
        515                 520                 525             
Pro Phe Val Arg Thr Asn Ser Val Lys Thr Thr Leu Ser Glu Ser Asp
    530                 535                 540                 
Pro His Leu Asp Arg Asn Thr Leu Pro Lys Lys Gly Leu Arg Tyr Thr
545                 550                 555                 560 
Pro Thr Ser Gln Leu Arg Thr Gln Glu Asp Ala Lys Glu Trp Leu Arg
                565                 570                 575     
Ser His Ser Ala Gly Gly Leu Gln Asp Thr Ala Ala Asn Ser Pro Phe
            580                 585                 590         
Ser Ser Gly Ser Ser Val Thr Ser Pro Ser Gly Thr Arg Phe Asn Phe
        595                 600                 605             
Ser Gln Leu Ala Ser Pro Thr Thr Val Thr Gln Met Ser Leu Ser Asn
    610                 615                 620                 
Pro Thr Met Leu Arg Thr His Ser Leu Ser Asn Ala Asp Gly Gln Tyr
625                 630                 635                 640 
Asp Pro Tyr Thr Asp Ser Arg Phe Arg Asn Ser Ser Met Ser Leu Asp
                645                 650                 655     
Glu Lys Ser Arg Thr Met Ser Arg Ser Gly Ser Phe Arg Asp Gly Phe
            660                 665                 670         
Glu Glu Val His Gly Ser Ser Leu Ser Leu Val Ser Ser Thr Ser Ser
        675                 680                 685             
Val Tyr Ser Thr Pro Glu Glu Lys Cys Gln Ser Glu Ile Arg Lys Leu
    690                 695                 700                 
Arg Arg Glu Leu Asp Ala Ser Gln Glu Lys Val Ser Ala Leu Thr Thr
705                 710                 715                 720 
Gln Leu Thr Ala Asn Ala His Leu Val Ala Ala Phe Glu Gln Ser Leu
                725                 730                 735     
Gly Asn Met Thr Ile Arg Leu Gln Ser Leu Thr Met Thr Ala Glu Gln
            740                 745                 750         
Lys Asp Ser Glu Leu Asn Glu Leu Arg Lys Thr Ile Glu Leu Leu Lys
        755                 760                 765             
Lys Gln Asn Ala Ala Ala Gln Ala Ala Ile Asn Gly Val Ile Asn Thr
    770                 775                 780                 
Pro Glu Leu Asn Cys Lys Gly Asn Gly Thr Ala Gln Ser Ala Asp Leu
785                 790                 795                 800 
Arg Ile Arg Arg Gln His Ser Ser Asp Ser Val Ser Ser Ile Asn Ser
                805                 810                 815     
Ala Thr Ser His Ser Ser Val Gly Ser Asn Ile Glu Ser Asp Ser Lys
            820                 825                 830         
Lys Lys Lys Arg Lys Asn Trp Leu Arg Ser Ser Phe Lys Gln Ala Phe
        835                 840                 845             
Gly Lys Lys Lys Ser Pro Lys Ser Ala Ser Ser His Ser Asp Ile Glu
    850                 855                 860                 
Glu Met Thr Asp Ser Ser Leu Pro Ser Ser Pro Lys Leu Pro His Asn
865                 870                 875                 880 
Gly Ser Thr Gly Ser Thr Pro Leu Leu Arg Asn Ser His Ser Asn Ser
                885                 890                 895     
Leu Ile Ser Glu Cys Met Asp Ser Glu Ala Glu Thr Val Met Gln Leu
            900                 905                 910         
Arg Asn Glu Leu Arg Asp Lys Glu Met Lys Leu Thr Asp Ile Arg Leu
        915                 920                 925             
Glu Ala Leu Ser Ser Ala His Gln Leu Asp Gln Leu Arg Glu Ala Val
    930                 935                 940                 
Asn Arg Met Gln Ser Glu Ile Glu Lys Leu Lys Ala Glu Asn Asp Arg
945                 950                 955                 960 
Leu Lys Ser Glu Ser Gln Gly Ser Gly Cys Ser Arg Ala Pro Ser Gln
                965                 970                 975     
Val Ser Ile Ser Ala Ser Pro Arg Gln Ser Met Gly Leu Ser Gln His
            980                 985                 990         
Ser Leu Asn Leu Thr Glu Ser Thr Ser Leu Asp Met Leu Leu Asp Asp
        995                 1000                1005            
Thr Gly Glu Cys Ser Ala Arg Lys Glu Gly Gly Arg His Val Lys Ile
    1010                1015                1020                
Val Val Ser Phe Gln Glu Glu Met Lys Trp Lys Glu Asp Ser Arg Pro
1025                1030                1035                1040
His Leu Phe Leu Ile Gly Cys Ile Gly Val Ser Gly Lys Thr Lys Trp
                1045                1050                1055    
Asp Val Leu Asp Gly Val Val Arg Arg Leu Phe Lys Glu Tyr Ile Ile
            1060                1065                1070        
His Val Asp Pro Val Ser Gln
        1075                


<210> 5556
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 5556
Met Pro Ala Ile Leu Val Ala Ser Lys Met Lys Ser Gly Leu Pro Lys
 1               5                  10                  15      
Pro Val His Ser Ala Ala Pro Ile Leu His Val Pro Pro Ala Arg Ala
            20                  25                  30          
Gly Pro Gln Pro Cys Tyr Leu Lys Leu Gly Ser Lys Val Glu Val Ser
        35                  40                  45              
Lys Thr Thr Tyr Pro Ser Gln Ile Pro Leu Lys Ser Gln Val Leu Gln
    50                  55                  60                  
Gly Leu Gln Glu Pro Ala Gly Glu Gly Leu Pro Leu Arg Lys Ser Gly
65                  70                  75                  80  
Ser Val Glu Asn Gly Phe Asp Thr Gln Ile Tyr Thr Asp Trp Ala Asn
                85                  90                  95      
His Tyr Leu Ala Lys Ser Gly His Lys Arg Leu Ile Arg Asp Leu Gln
            100                 105                 110         
Gln Asp Val Thr Asp Gly Val Leu Leu Ala Gln Ile Ile Gln Val Val
        115                 120                 125             
Ala Asn Glu Lys Ile Glu Asp Ile Asn Gly Cys Pro Lys Asn Arg Ser
    130                 135                 140                 
Gln Met Ile Glu Asn Ile Asp Ala Cys Leu Asn Phe Leu Ala Ala Lys
145                 150                 155                 160 
Gly Ile Asn Ile Gln Gly Leu Ser Ala Glu Glu Ile Arg Asn Gly Asn
                165                 170                 175     
Leu Lys Ala Ile Leu Gly Leu Phe Phe Ser Leu Ser Arg Tyr Lys Gln
            180                 185                 190         
Gln Gln Gln Gln Pro Gln Lys Gln His Leu Ser Ser Pro Leu Pro Pro
        195                 200                 205             
Ala Val Ser Gln Val Ala Gly Ala Pro Ser Gln Cys Gln Ala Gly Thr
    210                 215                 220                 
Pro Gln Gln Gln Val Pro Val Thr Pro Gln Ala Pro Cys Gln Pro His
225                 230                 235                 240 
Gln Pro Ala Pro His Gln Gln Ser Lys Ala Gln Ala Glu Met Gln Ser
                245                 250                 255     
Ser Ala Ser Ser Lys Asp Ser Ser Gln Ser Lys Ile Ile Arg Phe Thr
            260                 265                 270         
Leu Gly Gln Lys Lys Ile Ser Arg Leu Pro Gly Pro Thr Ala Arg Val
        275                 280                 285             
Ser Ala Ala Gly Ser Glu Ala Lys Thr Arg Gly Gly Ser Thr Thr Ala
    290                 295                 300                 
Asn Asn Arg Arg Ser Gln Ser Phe Asn Asn Tyr Asp Lys Ser Lys Pro
305                 310                 315                 320 
Val Thr Ser Pro Pro Pro Pro Pro Ser Ser His Glu Lys Glu Pro Leu
                325                 330                 335     
Ala Ser Ser Ala Ser Ser His Pro Gly Met Ser Asp Asn Ala Pro Ala
            340                 345                 350         
Ser Leu Glu Ser Gly Ser Ser Ser Thr Pro Thr Asn Cys Ser Thr Ser
        355                 360                 365             
Ser Ala Ile Pro Gln Pro Gly Ala Ala Thr Lys Pro Trp Arg Ser Lys
    370                 375                 380                 
Ser Leu Ser Val Lys His Ser Ala Thr Val Ser Met Leu Ser Val Lys
385                 390                 395                 400 
Pro Pro Gly Pro Glu Ala Pro Arg Pro Thr Pro Glu Ala Met Lys Pro
                405                 410                 415     
Ala Pro Asn Asn Gln Lys Ser Met Leu Glu Lys Leu Lys Leu Phe Asn
            420                 425                 430         
Ser Lys Gly Gly Ser Lys Ala Gly Glu Gly Pro Gly Ser Arg Asp Thr
        435                 440                 445             
Ser Cys Glu Arg Leu Glu Thr Leu Pro Ser Phe Glu Glu Ser Glu Glu
    450                 455                 460                 
Leu Glu Ala Ala Ser Arg Met Leu Thr Thr Val Gly Pro Ala Ser Ser
465                 470                 475                 480 
Ser Pro Lys Ile Ala Leu Lys Gly Ile Ala Gln Arg Thr Phe Ser Arg
                485                 490                 495     
Ala Leu Thr Asn Lys Lys Ser Ser Leu Lys Gly Asn Glu Lys Glu Lys
            500                 505                 510         
Glu Lys Gln Gln Arg Glu Lys Asp Lys Glu Lys Ser Lys Asp Leu Ala
        515                 520                 525             
Lys Arg Ala Ser Val Thr Glu Arg Leu Asp Leu Lys Glu Glu Pro Lys
    530                 535                 540                 
Glu Asp Pro Ser Gly Ala Ala Val Pro Glu Met Pro Lys Lys Ser Ser
545                 550                 555                 560 
Lys Ile Ala Ser Phe Ile Pro Lys Gly Gly Lys Leu Asn Ser Ala Lys
                565                 570                 575     
Lys Glu Pro Met Ala Pro Ser His Ser Gly Ile Pro Lys Pro Gly Met
            580                 585                 590         
Lys Ser Met Pro Gly Lys Ser Pro Ser Ala Pro Ala Pro Ser Lys Glu
        595                 600                 605             
Gly Glu Arg Ser Arg Ser Gly Lys Leu Ser Ser Gly Leu Pro Gln Gln
    610                 615                 620                 
Lys Pro Gln Leu Asp Gly Arg His Ser Ser Ser Ser Ser Ser Leu Ala
625                 630                 635                 640 
Ser Ser Glu Gly Lys Gly Pro Gly Gly Thr Thr Leu Asn His Ser Ile
                645                 650                 655     
Ser Ser Gln Thr Val Ser Gly Ser Val Gly Thr Thr Gln Thr Thr Gly
            660                 665                 670         
Ser Asn Thr Val Ser Val Gln Leu Pro Gln Pro Gln Gln Gln Tyr Asn
        675                 680                 685             
His Pro Asn Thr Ala Thr Val Ala Pro Phe Leu Tyr Arg Ser Gln Thr
    690                 695                 700                 
Asp Thr Glu Gly Asn Val Thr Ala Glu Ser Ser Ser Thr Gly Val Ser
705                 710                 715                 720 
Val Glu Pro Ser His Phe Thr Lys Thr Gly Gln Pro Ala Leu Glu Glu
                725                 730                 735     
Leu Thr Gly Glu Asp Pro Glu Ala Arg Arg Leu Arg Thr Val Lys Asn
            740                 745                 750         
Ile Ala Asp Leu Arg Gln Asn Leu Glu Glu Thr Met Ser Ser Leu Arg
        755                 760                 765             
Gly Thr Gln Val Thr His Ser Thr Leu Glu Thr Thr Phe Asp Thr Asn
    770                 775                 780                 
Val Thr Thr Glu Met Ser Gly Arg Ser Ile Leu Ser Leu Thr Gly Arg
785                 790                 795                 800 
Pro Thr Pro Leu Ser Trp Arg Leu Gly Gln Ser Ser Pro Arg Leu Gln
                805                 810                 815     
Ala Gly Asp Ala Pro Ser Met Gly Asn Gly Tyr Pro Pro Arg Ala Asn
            820                 825                 830         
Ala Ser Arg Phe Ile Asn Thr Glu Ser Gly Arg Tyr Val Tyr Ser Ala
        835                 840                 845             
Pro Leu Arg Arg Gln Leu Ala Ser Arg Gly Ser Ser Val Cys His Val
    850                 855                 860                 
Asp Val Ser Asp Lys Ala Gly Asp Glu Met Asp Leu Glu Gly Ile Ser
865                 870                 875                 880 
Met Asp Ala Pro Gly Tyr Met Ser Asp Gly Asp Val Leu Ser Lys Asn
                885                 890                 895     
Ile Arg Thr Asp Asp Ile Thr Ser Gly Tyr Met Thr Asp Gly Gly Leu
            900                 905                 910         
Gly Leu Tyr Thr Arg Arg Leu Asn Arg Leu Pro Asp Gly Met Ala Val
        915                 920                 925             
Val Arg Glu Thr Leu Gln Arg Asn Thr Ser Leu Gly Leu Gly Asp Ala
    930                 935                 940                 
Asp Ser Trp Asp Asp Ser Ser Ser Val Ser Ser Gly Ile Ser Asp Thr
945                 950                 955                 960 
Ile Asp Asn Leu Ser Thr Asp Asp Ile Asn Thr Ser Ser Ser Ile Ser
                965                 970                 975     
Ser Tyr Ala Asn Thr Pro Ala Ser Ser Arg Lys Asn Leu Asp Val Gln
            980                 985                 990         
Thr Asp Ala Glu Lys His Ser Gln Val Glu Arg Asn Ser Leu Trp Ser
        995                 1000                1005            
Gly Asp Asp Val Lys Lys Ser Asp Gly Gly Ser Asp Ser Gly Ile Lys
    1010                1015                1020                
Met Glu Pro Gly Ser Lys Trp Arg Arg Asn Pro Ser Asp Val Ser Asp
1025                1030                1035                1040
Glu Ser Asp Lys Ser Thr Ser Gly Lys Lys Asn Pro Val Ile Ser Gln
                1045                1050                1055    
Thr Gly Ser Trp Arg Arg Gly Met Thr Ala Gln Val Gly Ile Thr Met
            1060                1065                1070        
Pro Arg Thr Lys Pro Ser Ala Pro Ala Gly Ala Leu Lys Thr Pro Gly
        1075                1080                1085            
Thr Gly Lys Thr Asp Asp Ala Lys Val Ser Glu Lys Gly Arg Leu Ser
    1090                1095                1100                
Pro Lys Ala Ser Gln Val Lys Arg Ser Pro Ser Asp Ala Gly Arg Ser
1105                1110                1115                1120
Ser Gly Asp Glu Ser Lys Lys Pro Leu Pro Ser Ser Ser Arg Thr Pro
                1125                1130                1135    
Thr Ala Asn Ala Asn Ser Phe Gly Phe Lys Lys Gln Ser Gly Ser Ala
            1140                1145                1150        
Ala Gly Leu Ala Met Ile Thr Ala Ser Gly Val Thr Val Thr Ser Arg
        1155                1160                1165            
Ser Ala Thr Leu Gly Lys Ile Pro Lys Ser Ser Ala Leu Val Ser Arg
    1170                1175                1180                
Ser Ala Gly Arg Lys Ser Ser Met Asp Gly Ala Gln Asn Gln Asp Asp
1185                1190                1195                1200
Gly Tyr Leu Ala Leu Ser Ser Arg Thr Asn Leu Gln Tyr Arg Ser Leu
                1205                1210                1215    
Pro Arg Pro Ser Lys Ser Asn Ser Arg Asn Gly Ala Gly Asn Arg Ser
            1220                1225                1230        
Ser Thr Ser Ser Ile Asp Ser Asn Ile Ser Ser Lys Ser Ala Gly Leu
        1235                1240                1245            
Pro Val Pro Lys Leu Arg Glu Pro Ser Lys Thr Ala Leu Gly Ser Ser
    1250                1255                1260                
Leu Pro Gly Leu Val Asn Gln Thr Asp Lys Glu Lys Gly Ile Ser Ser
1265                1270                1275                1280
Asp Asn Glu Ser Val Ala Ser Cys Asn Ser Val Lys Val Asn Pro Ala
                1285                1290                1295    
Ala Gln Pro Val Ser Ser Pro Ala Gln Thr Ser Leu Gln Pro Gly Ala
            1300                1305                1310        
Lys Tyr Pro Asp Val Ala Ser Pro Thr Leu Arg Arg Leu Phe Gly Gly
        1315                1320                1325            
Lys Pro Thr Lys Gln Val Pro Ile Ala Thr Ala Glu Asn Met Lys Asn
    1330                1335                1340                
Ser Val Val Ile Ser Asn Pro His Ala Thr Met Thr Gln Gln Gly Asn
1345                1350                1355                1360
Leu Asp Ser Pro Ser Gly Ser Gly Val Leu Ser Ser Gly Ser Ser Ser
                1365                1370                1375    
Pro Leu Tyr Ser Lys Asn Val Asp Leu Asn Gln Ser Pro Leu Ala Ser
            1380                1385                1390        
Ser Pro Ser Ser Ala His Ser Ala Pro Ser Asn Ser Leu Thr Trp Gly
        1395                1400                1405            
Thr Asn Ala Ser Ser Ser Ser Ala Val Ser Lys Asp Gly Leu Gly Phe
    1410                1415                1420                
Gln Ser Val Ser Ser Leu His Thr Ser Cys Glu Ser Ile Asp Ile Ser
1425                1430                1435                1440
Leu Ser Ser Gly Gly Val Pro Ser His Asn Ser Ser Thr Gly Leu Ile
                1445                1450                1455    
Ala Ser Ser Lys Asp Asp Ser Leu Thr Pro Phe Val Arg Thr Asn Ser
            1460                1465                1470        
Val Lys Thr Thr Leu Ser Glu Ser Pro Leu Ser Ser Pro Ala Ala Ser
        1475                1480                1485            
Pro Lys Phe Cys Arg Ser Thr Leu Pro Arg Lys Gln Asp Ser Asp Pro
    1490                1495                1500                
His Leu Asp Arg Asn Thr Leu Pro Lys Lys Gly Leu Arg Tyr Thr Pro
1505                1510                1515                1520
Thr Ser Gln Leu Arg Thr Gln Glu Asp Ala Lys Glu Trp Leu Arg Ser
                1525                1530                1535    
His Ser Ala Gly Gly Leu Gln Asp Thr Ala Ala Asn Ser Pro Phe Ser
            1540                1545                1550        
Ser Gly Ser Ser Val Thr Ser Pro Ser Gly Thr Arg Phe Asn Phe Ser
        1555                1560                1565            
Gln Leu Ala Ser Pro Thr Thr Val Thr Gln Met Ser Leu Ser Asn Pro
    1570                1575                1580                
Thr Met Leu Arg Thr His Ser Leu Ser Asn Ala Asp Gly Gln Tyr Asp
1585                1590                1595                1600
Pro Tyr Thr Asp Ser Arg Phe Arg Asn Ser Ser Met Ser Leu Asp Glu
                1605                1610                1615    
Lys Ser Arg Thr Met Ser Arg Ser Gly Ser Phe Arg Asp Gly Phe Glu
            1620                1625                1630        
Glu Glu Ser Trp Glu Lys Ser Ser Val Asp Asn Phe Val Ser Arg Leu
        1635                1640                1645            
His Ser Ser Leu His Phe Ser Leu Pro Leu Phe His His Ala Arg Tyr
    1650                1655                1660                
Glu Leu Val His Gly Ser Ser Leu Ser Leu Val Ser Ser Thr Ser Ser
1665                1670                1675                1680
Val Tyr Ser Thr Pro Glu Glu Lys Cys Gln Ser Glu Ile Arg Lys Leu
                1685                1690                1695    
Arg Arg Glu Leu Asp Ala Ser Gln Glu Lys Val Ser Ala Leu Thr Thr
            1700                1705                1710        
Gln Leu Thr Ala Asn Ala His Leu Val Ala Ala Phe Glu Gln Ser Leu
        1715                1720                1725            
Gly Asn Met Thr Ile Arg Leu Gln Ser Leu Thr Met Thr Ala Glu Gln
    1730                1735                1740                
Lys Asp Ser Glu Leu Asn Glu Leu Arg Lys Thr Ile Glu Leu Leu Lys
1745                1750                1755                1760
Lys Gln Asn Ala Ala Ala Gln Ala Ala Ile Asn Gly Val Ile Asn Thr
                1765                1770                1775    
Pro Glu Leu Asn Cys Lys Gly Asn Gly Thr Ala Gln Ser Ala Asp Leu
            1780                1785                1790        
Arg Ile Arg Arg Gln His Ser Ser Asp Ser Val Ser Ser Ile Asn Ser
        1795                1800                1805            
Ala Thr Ser His Ser Ser Val Gly Ser Asn Ile Glu Ser Asp Ser Lys
    1810                1815                1820                
Lys Lys Lys Arg Lys Asn Trp Val Ile Leu Tyr Ile Gln Leu Arg Ser
1825                1830                1835                1840
Ser Phe Lys Gln Ala Phe Gly Lys Lys Lys Ser Pro Lys Ser Ala Ser
                1845                1850                1855    
Ser His Ser Asp Ile Glu Glu Met Thr Asp Ser Ser Leu Pro Ser Ser
            1860                1865                1870        
Pro Lys Leu Pro His Asn Gly Ser Thr Gly Ser Thr Pro Leu Leu Arg
        1875                1880                1885            
Asn Ser His Ser Asn Ser Leu Ile Ser Glu Cys Met Asp Ser Glu Ala
    1890                1895                1900                
Glu Thr Val Met Gln Leu Arg Asn Glu Leu Arg Asp Lys Glu Met Lys
1905                1910                1915                1920
Leu Thr Asp Ile Arg Leu Glu Ala Leu Ser Ser Ala His Gln Leu Asp
                1925                1930                1935    
Gln Leu Arg Glu Ala Met Asn Arg Met Gln Ser Glu Ile Glu Lys Leu
            1940                1945                1950        
Lys Ala Glu Asn Asp Arg Leu Lys Ser Glu Ser Gln Gly Ser Gly Cys
        1955                1960                1965            
Ser Arg Ala Pro Ser Gln Val Ser Ile Ser Ala Ser Pro Arg Gln Ser
    1970                1975                1980                
Met Gly Leu Ser Gln His Ser Leu Asn Leu Thr Glu Ser Thr Ser Leu
1985                1990                1995                2000
Asp Met Leu Leu Asp Asp Thr Gly Glu Cys Ser Ala Arg Lys Glu Gly
                2005                2010                2015    
Gly Arg His Val Lys Ile Val Val Ser Phe Gln Glu Glu Met Lys Trp
            2020                2025                2030        
Lys Glu Asp Ser Arg Pro His Leu Phe Leu Ile Gly Cys Ile Gly Val
        2035                2040                2045            
Ser Gly Lys Thr Lys Trp Asp Val Leu Asp Gly Val Val Arg Arg Leu
    2050                2055                2060                
Phe Lys Glu Tyr Ile Ile His Val Asp Pro Val Ser Gln Leu Gly Leu
2065                2070                2075                2080
Asn Ser Asp Ser Val Leu Gly Tyr Ser Ile Gly Glu Ile Lys Arg Ser
                2085                2090                2095    
Asn Thr Ser Glu Thr Pro Glu Leu Leu Pro Cys Gly Tyr Leu Val Gly
            2100                2105                2110        
Glu Asn Thr Thr Ile Ser Val Thr Val Lys Gly Leu Ala Glu Asn Ser
        2115                2120                2125            
Leu Asp Ser Leu Val Phe Glu Ser Leu Ile Pro Lys Pro Ile Leu Gln
    2130                2135                2140                
Arg Tyr Val Ser Leu Leu Ile Glu His Arg Arg Ile Ile Leu Ser Gly
2145                2150                2155                2160
Pro Ser Gly Thr Gly Lys Thr Tyr Leu Ala Asn Arg Leu Ser Glu Tyr
                2165                2170                2175    
Ile Val Leu Arg Glu Gly Arg Glu Leu Thr Asp Gly Val Ile Ala Thr
            2180                2185                2190        
Phe Asn Val Asp His Lys Ser Ser Lys Glu Leu Arg Gln Tyr Leu Ser
        2195                2200                2205            
Asn Leu Ala Asp Gln Cys Asn Ser Glu Asn Asn Ala Val Asp Met Pro
    2210                2215                2220                
Leu Val Ile Ile Leu Asp Asn Leu His His Val Ser Ser Leu Gly Glu
2225                2230                2235                2240
Ile Phe Asn Gly Leu Leu Asn Cys Lys Tyr His Lys Cys Pro Tyr Ile
                2245                2250                2255    
Ile Gly Thr Met Asn Gln Ala Thr Ser Ser Thr Pro Asn Leu Gln Leu
            2260                2265                2270        
His His Asn Phe Arg Trp Val Leu Cys Ala Asn His Thr Glu Pro Val
        2275                2280                2285            
Lys Gly Phe Leu Gly Arg Phe Leu Arg Arg Lys Leu Met Glu Thr Glu
    2290                2295                2300                
Ile Ser Gly Arg Val Arg Asn Met Glu Leu Val Lys Ile Ile Asp Trp
2305                2310                2315                2320
Ile Pro Lys Val Trp His His Leu Asn Arg Phe Leu Glu Ala His Ser
                2325                2330                2335    
Ser Ser Asp Val Thr Ile Gly Pro Arg Leu Phe Leu Ser Cys Pro Ile
            2340                2345                2350        
Asp Val Asp Gly Ser Arg Val Trp Phe Thr Asp Leu Trp Asn Tyr Ser
        2355                2360                2365            
Ile Ile Pro Tyr Leu Leu Glu Ala Val Arg Glu Gly Leu Gln Leu Tyr
    2370                2375                2380                
Gly Arg Arg Ala Pro Trp Glu Asp Pro Ala Lys Trp Val Met Asp Thr
2385                2390                2395                2400
Tyr Pro Trp Ala Ala Ser Pro Gln Gln His Glu Trp Pro Pro Leu Leu
                2405                2410                2415    
Gln Leu Arg Pro Glu Asp Val Gly Phe Asp Gly Tyr Ser Met Pro Arg
            2420                2425                2430        
Glu Gly Ser Thr Ser Lys Gln Met Pro Pro Ser Asp Ala Glu Gly Asp
        2435                2440                2445            
Pro Leu Met Asn Met Leu Met Arg Leu Gln Glu Ala Ala Asn Tyr Ser
    2450                2455                2460                
Ser Pro Gln Ser Tyr Asp Ser Asp Ser Asn Ser Asn Ser His His Asp
2465                2470                2475                2480
Asp Ile Leu Asp Ser Ser Leu Glu Ser Thr Leu
                2485                2490    


<210> 5557
<211> 2429
<212> PRT
<213> Homo sapiens

<400> 5557
Met Pro Ala Ile Leu Val Ala Ser Lys Met Lys Ser Gly Leu Pro Lys
 1               5                  10                  15      
Pro Val His Ser Ala Ala Pro Ile Leu His Val Pro Pro Ala Arg Ala
            20                  25                  30          
Gly Pro Gln Pro Cys Tyr Leu Lys Leu Gly Ser Lys Val Glu Val Ser
        35                  40                  45              
Lys Thr Thr Tyr Pro Ser Gln Ile Pro Leu Lys Ser Gln Val Leu Gln
    50                  55                  60                  
Gly Leu Gln Glu Pro Ala Gly Glu Gly Leu Pro Leu Arg Lys Ser Gly
65                  70                  75                  80  
Ser Val Glu Asn Gly Phe Asp Thr Gln Ile Tyr Thr Asp Trp Ala Asn
                85                  90                  95      
His Tyr Leu Ala Lys Ser Gly His Lys Arg Leu Ile Arg Asp Leu Gln
            100                 105                 110         
Gln Asp Val Thr Asp Gly Val Leu Leu Ala Gln Ile Ile Gln Val Val
        115                 120                 125             
Ala Asn Glu Lys Ile Glu Asp Ile Asn Gly Cys Pro Lys Asn Arg Ser
    130                 135                 140                 
Gln Met Ile Glu Asn Ile Asp Ala Cys Leu Asn Phe Leu Ala Ala Lys
145                 150                 155                 160 
Gly Ile Asn Ile Gln Gly Leu Ser Ala Glu Glu Ile Arg Asn Gly Asn
                165                 170                 175     
Leu Lys Ala Ile Leu Gly Leu Phe Phe Ser Leu Ser Arg Tyr Lys Gln
            180                 185                 190         
Gln Gln Gln Gln Pro Gln Lys Gln His Leu Ser Ser Pro Leu Pro Pro
        195                 200                 205             
Ala Val Ser Gln Val Ala Gly Ala Pro Ser Gln Cys Gln Ala Gly Thr
    210                 215                 220                 
Pro Gln Gln Gln Val Pro Val Thr Pro Gln Ala Pro Cys Gln Pro His
225                 230                 235                 240 
Gln Pro Ala Pro His Gln Gln Ser Lys Ala Gln Ala Glu Met Gln Ser
                245                 250                 255     
Arg Leu Pro Gly Pro Thr Ala Arg Val Ser Ala Ala Gly Ser Glu Ala
            260                 265                 270         
Lys Thr Arg Gly Gly Ser Thr Thr Ala Asn Asn Arg Arg Ser Gln Ser
        275                 280                 285             
Phe Asn Asn Tyr Asp Lys Ser Lys Pro Val Thr Ser Pro Pro Pro Pro
    290                 295                 300                 
Pro Ser Ser His Glu Lys Glu Pro Leu Ala Ser Ser Ala Ser Ser His
305                 310                 315                 320 
Pro Gly Met Ser Asp Asn Ala Pro Ala Ser Leu Glu Ser Gly Ser Ser
                325                 330                 335     
Ser Thr Pro Thr Asn Cys Ser Thr Ser Ser Ala Ile Pro Gln Pro Gly
            340                 345                 350         
Ala Ala Thr Lys Pro Trp Arg Ser Lys Ser Leu Ser Val Lys His Ser
        355                 360                 365             
Ala Thr Val Ser Met Leu Ser Val Lys Pro Pro Gly Pro Glu Ala Pro
    370                 375                 380                 
Arg Pro Thr Pro Glu Ala Met Lys Pro Ala Pro Asn Asn Gln Lys Ser
385                 390                 395                 400 
Met Leu Glu Lys Leu Lys Leu Phe Asn Ser Lys Gly Gly Ser Lys Ala
                405                 410                 415     
Gly Glu Gly Pro Gly Ser Arg Asp Thr Ser Cys Glu Arg Leu Glu Thr
            420                 425                 430         
Leu Pro Ser Phe Glu Glu Ser Glu Glu Leu Glu Ala Ala Ser Arg Met
        435                 440                 445             
Leu Thr Thr Val Gly Pro Ala Ser Ser Ser Pro Lys Ile Ala Leu Lys
    450                 455                 460                 
Gly Ile Ala Gln Arg Thr Phe Ser Arg Ala Leu Thr Asn Lys Lys Ser
465                 470                 475                 480 
Ser Leu Lys Gly Asn Glu Lys Glu Lys Glu Lys Gln Gln Arg Glu Lys
                485                 490                 495     
Asp Lys Glu Lys Ser Lys Asp Leu Ala Lys Arg Ala Ser Val Thr Glu
            500                 505                 510         
Arg Leu Asp Leu Lys Glu Glu Pro Lys Glu Asp Pro Ser Gly Ala Ala
        515                 520                 525             
Val Pro Glu Met Pro Lys Lys Ser Ser Lys Ile Ala Ser Phe Ile Pro
    530                 535                 540                 
Lys Gly Gly Lys Leu Asn Ser Ala Lys Lys Glu Pro Met Ala Pro Ser
545                 550                 555                 560 
His Ser Gly Ile Pro Lys Pro Gly Met Lys Ser Met Pro Gly Lys Ser
                565                 570                 575     
Pro Ser Ala Pro Ala Pro Ser Lys Glu Gly Glu Arg Ser Arg Ser Gly
            580                 585                 590         
Lys Leu Ser Ser Gly Leu Pro Gln Gln Lys Pro Gln Leu Asp Gly Arg
        595                 600                 605             
His Ser Ser Ser Ser Ser Ser Leu Ala Ser Ser Glu Gly Lys Gly Pro
    610                 615                 620                 
Gly Gly Thr Thr Leu Asn His Ser Ile Ser Ser Gln Thr Val Ser Gly
625                 630                 635                 640 
Ser Val Gly Thr Thr Gln Thr Thr Gly Ser Asn Thr Val Ser Val Gln
                645                 650                 655     
Leu Pro Gln Pro Gln Gln Gln Tyr Asn His Pro Asn Thr Ala Thr Val
            660                 665                 670         
Ala Pro Phe Leu Tyr Arg Ser Gln Thr Asp Thr Glu Gly Asn Val Thr
        675                 680                 685             
Ala Glu Ser Ser Ser Thr Gly Val Ser Val Glu Pro Ser His Phe Thr
    690                 695                 700                 
Lys Thr Gly Gln Pro Ala Leu Glu Glu Leu Thr Gly Glu Asp Pro Glu
705                 710                 715                 720 
Ala Arg Arg Leu Arg Thr Val Lys Asn Ile Ala Asp Leu Arg Gln Asn
                725                 730                 735     
Leu Glu Glu Thr Met Ser Ser Leu Arg Gly Thr Gln Val Thr His Ser
            740                 745                 750         
Thr Leu Glu Thr Thr Phe Asp Thr Asn Val Thr Thr Glu Met Ser Gly
        755                 760                 765             
Arg Ser Ile Leu Ser Leu Thr Gly Arg Pro Thr Pro Leu Ser Trp Arg
    770                 775                 780                 
Leu Gly Gln Ser Ser Pro Arg Leu Gln Ala Gly Asp Ala Pro Ser Met
785                 790                 795                 800 
Gly Asn Gly Tyr Pro Pro Arg Ala Asn Ala Ser Arg Phe Ile Asn Thr
                805                 810                 815     
Glu Ser Gly Arg Tyr Val Tyr Ser Ala Pro Leu Arg Arg Gln Leu Ala
            820                 825                 830         
Ser Arg Gly Ser Ser Val Cys His Val Asp Val Ser Asp Lys Ala Gly
        835                 840                 845             
Asp Glu Met Asp Leu Glu Gly Ile Ser Met Asp Ala Pro Gly Tyr Met
    850                 855                 860                 
Ser Asp Gly Asp Val Leu Ser Lys Asn Ile Arg Thr Asp Asp Ile Thr
865                 870                 875                 880 
Ser Gly Tyr Met Thr Asp Gly Gly Leu Gly Leu Tyr Thr Arg Arg Leu
                885                 890                 895     
Asn Arg Leu Pro Asp Gly Met Ala Val Val Arg Glu Thr Leu Gln Arg
            900                 905                 910         
Asn Thr Ser Leu Gly Leu Gly Asp Ala Asp Ser Trp Asp Asp Ser Ser
        915                 920                 925             
Ser Val Ser Ser Gly Ile Ser Asp Thr Ile Asp Asn Leu Ser Thr Asp
    930                 935                 940                 
Asp Ile Asn Thr Ser Ser Ser Ile Ser Ser Tyr Ala Asn Thr Pro Ala
945                 950                 955                 960 
Ser Ser Arg Lys Asn Leu Asp Val Gln Thr Asp Ala Glu Lys His Ser
                965                 970                 975     
Gln Val Glu Arg Asn Ser Leu Trp Ser Gly Asp Asp Val Lys Lys Ser
            980                 985                 990         
Asp Gly Gly Ser Asp Ser Gly Ile Lys Met Glu Pro Gly Ser Lys Trp
        995                 1000                1005            
Arg Arg Asn Pro Ser Asp Val Ser Asp Glu Ser Asp Lys Ser Thr Ser
    1010                1015                1020                
Gly Lys Lys Asn Pro Val Ile Ser Gln Thr Gly Ser Trp Arg Arg Gly
1025                1030                1035                1040
Met Thr Ala Gln Val Gly Ile Thr Met Pro Arg Thr Lys Ala Ser Ala
                1045                1050                1055    
Pro Ala Gly Ala Leu Lys Thr Pro Gly Thr Gly Lys Thr Asp Asp Ala
            1060                1065                1070        
Lys Val Ser Glu Lys Gly Arg Leu Ser Pro Lys Ala Ser Gln Val Lys
        1075                1080                1085            
Arg Ser Pro Ser Asp Ala Gly Arg Ser Ser Gly Asp Glu Ser Lys Lys
    1090                1095                1100                
Pro Leu Pro Ser Ser Ser Arg Thr Pro Thr Ala Asn Ala Asn Ser Phe
1105                1110                1115                1120
Gly Phe Lys Lys Gln Ser Gly Ser Ala Ala Gly Leu Ala Met Ile Thr
                1125                1130                1135    
Ala Ser Gly Val Thr Val Thr Ser Arg Ser Ala Thr Leu Gly Lys Ile
            1140                1145                1150        
Pro Lys Ser Ser Ala Leu Val Ser Arg Ser Ala Gly Arg Lys Ser Ser
        1155                1160                1165            
Met Asp Gly Ala Gln Asn Gln Asp Asp Gly Tyr Leu Ala Leu Ser Ser
    1170                1175                1180                
Arg Thr Asn Leu Gln Tyr Arg Ser Leu Pro Arg Pro Ser Lys Ser Asn
1185                1190                1195                1200
Ser Arg Asn Gly Ala Gly Asn Arg Ser Ser Thr Ser Ser Ile Asp Ser
                1205                1210                1215    
Asn Ile Ser Ser Lys Ser Ala Gly Leu Pro Val Pro Lys Leu Arg Glu
            1220                1225                1230        
Pro Ser Lys Thr Ala Leu Gly Ser Ser Leu Pro Gly Leu Val Asn Gln
        1235                1240                1245            
Thr Asp Lys Glu Lys Gly Ile Ser Ser Asp Asn Glu Ser Val Ala Ser
    1250                1255                1260                
Cys Asn Ser Val Lys Val Asn Pro Ala Ala Gln Pro Val Ser Ser Pro
1265                1270                1275                1280
Ala Gln Thr Ser Leu Gln Pro Gly Ala Lys Tyr Pro Asp Val Ala Ser
                1285                1290                1295    
Pro Thr Leu Arg Arg Leu Phe Gly Gly Lys Pro Thr Lys Gln Val Pro
            1300                1305                1310        
Ile Ala Thr Ala Glu Asn Met Lys Asn Ser Val Val Ile Ser Asn Pro
        1315                1320                1325            
His Ala Thr Met Thr Gln Gln Gly Asn Leu Asp Ser Pro Ser Gly Ser
    1330                1335                1340                
Gly Val Leu Ser Ser Gly Ser Ser Ser Pro Leu Tyr Ser Lys Asn Val
1345                1350                1355                1360
Asp Leu Asn Gln Ser Pro Leu Ala Ser Ser Pro Ser Ser Ala His Ser
                1365                1370                1375    
Ala Pro Ser Asn Ser Leu Thr Trp Gly Thr Asn Ala Ser Ser Ser Ser
            1380                1385                1390        
Ala Val Ser Lys Asp Gly Leu Gly Phe Gln Ser Val Ser Ser Leu His
        1395                1400                1405            
Thr Ser Cys Glu Ser Ile Asp Ile Ser Leu Ser Ser Gly Gly Val Pro
    1410                1415                1420                
Ser His Asn Ser Ser Thr Gly Leu Ile Ala Ser Ser Lys Asp Asp Ser
1425                1430                1435                1440
Leu Thr Pro Phe Val Arg Thr Asn Ser Val Lys Thr Thr Leu Ser Glu
                1445                1450                1455    
Ser Pro Leu Ser Ser Pro Ala Ala Ser Pro Lys Phe Cys Arg Ser Thr
            1460                1465                1470        
Leu Pro Arg Lys Gln Asp Ser Asp Pro His Leu Asp Arg Asn Thr Leu
        1475                1480                1485            
Pro Lys Lys Gly Leu Arg Tyr Thr Pro Thr Ser Gln Leu Arg Thr Gln
    1490                1495                1500                
Glu Asp Ala Lys Glu Trp Leu Arg Ser His Ser Ala Gly Gly Leu Gln
1505                1510                1515                1520
Asp Thr Ala Ala Asn Ser Pro Phe Ser Ser Gly Ser Ser Val Thr Ser
                1525                1530                1535    
Pro Ser Gly Thr Arg Phe Asn Phe Ser Gln Leu Ala Ser Pro Thr Thr
            1540                1545                1550        
Val Thr Gln Met Ser Leu Ser Asn Pro Thr Met Leu Arg Thr His Ser
        1555                1560                1565            
Leu Ser Asn Ala Asp Gly Gln Tyr Asp Pro Tyr Thr Asp Ser Arg Phe
    1570                1575                1580                
Arg Asn Ser Ser Met Ser Leu Asp Glu Lys Ser Arg Thr Met Ser Arg
1585                1590                1595                1600
Ser Gly Ser Phe Arg Asp Gly Phe Glu Glu Val His Gly Ser Ser Leu
                1605                1610                1615    
Ser Leu Val Ser Ser Thr Ser Ser Val Tyr Ser Thr Pro Glu Glu Lys
            1620                1625                1630        
Cys Gln Ser Glu Ile Arg Lys Leu Arg Arg Glu Leu Asp Ala Ser Gln
        1635                1640                1645            
Glu Lys Val Ser Ala Leu Thr Thr Gln Leu Thr Ala Asn Ala His Leu
    1650                1655                1660                
Val Ala Ala Phe Glu Gln Ser Leu Gly Asn Met Thr Ile Arg Leu Gln
1665                1670                1675                1680
Ser Leu Thr Met Thr Ala Glu Gln Lys Asp Ser Glu Leu Asn Glu Leu
                1685                1690                1695    
Arg Lys Thr Ile Glu Leu Leu Lys Lys Gln Asn Ala Ala Ala Gln Ala
            1700                1705                1710        
Ala Ile Asn Gly Val Ile Asn Thr Pro Glu Leu Asn Cys Lys Gly Asn
        1715                1720                1725            
Gly Thr Ala Gln Ser Ala Asp Leu Arg Ile Arg Arg Gln His Ser Ser
    1730                1735                1740                
Asp Ser Val Ser Ser Ile Asn Ser Ala Thr Ser His Ser Ser Val Gly
1745                1750                1755                1760
Ser Asn Ile Glu Ser Asp Ser Lys Lys Lys Lys Arg Lys Asn Trp Leu
                1765                1770                1775    
Arg Ser Ser Phe Lys Gln Ala Phe Gly Lys Lys Lys Ser Pro Lys Ser
            1780                1785                1790        
Ala Ser Ser His Ser Asp Ile Glu Glu Met Thr Asp Ser Ser Leu Pro
        1795                1800                1805            
Ser Ser Pro Lys Leu Pro His Asn Gly Ser Thr Gly Ser Thr Pro Leu
    1810                1815                1820                
Leu Arg Asn Ser His Ser Asn Ser Leu Ile Ser Glu Cys Met Asp Ser
1825                1830                1835                1840
Glu Ala Glu Thr Val Met Gln Leu Arg Asn Glu Leu Arg Asp Lys Glu
                1845                1850                1855    
Met Lys Leu Thr Asp Ile Arg Leu Glu Ala Leu Ser Ser Ala His Gln
            1860                1865                1870        
Leu Asp Gln Leu Arg Glu Ala Met Asn Arg Met Gln Ser Glu Ile Glu
        1875                1880                1885            
Lys Leu Lys Ala Glu Asn Asp Arg Leu Lys Ser Glu Ser Gln Gly Ser
    1890                1895                1900                
Gly Cys Ser Arg Ala Pro Ser Gln Val Ser Ile Ser Ala Ser Pro Arg
1905                1910                1915                1920
Gln Ser Met Gly Leu Ser Gln His Ser Leu Asn Leu Thr Glu Ser Thr
                1925                1930                1935    
Ser Leu Asp Met Leu Leu Asp Asp Thr Gly Glu Cys Ser Ala Arg Lys
            1940                1945                1950        
Glu Gly Gly Arg His Val Lys Ile Val Val Ser Phe Gln Glu Glu Met
        1955                1960                1965            
Lys Trp Lys Glu Asp Ser Arg Pro His Leu Phe Leu Ile Gly Cys Ile
    1970                1975                1980                
Gly Val Ser Gly Lys Thr Lys Trp Asp Val Leu Asp Gly Val Val Arg
1985                1990                1995                2000
Arg Leu Phe Lys Glu Tyr Ile Ile His Val Asp Pro Val Ser Gln Leu
                2005                2010                2015    
Gly Leu Asn Ser Asp Ser Val Leu Gly Tyr Ser Ile Gly Glu Ile Lys
            2020                2025                2030        
Arg Ser Asn Thr Ser Glu Thr Pro Glu Leu Leu Pro Cys Gly Tyr Leu
        2035                2040                2045            
Val Gly Glu Asn Thr Thr Ile Ser Val Thr Val Lys Gly Leu Ala Glu
    2050                2055                2060                
Asn Ser Leu Asp Ser Leu Val Phe Glu Ser Leu Ile Pro Lys Pro Ile
2065                2070                2075                2080
Leu Gln Arg Tyr Val Ser Leu Leu Ile Glu His Arg Arg Ile Ile Leu
                2085                2090                2095    
Ser Gly Pro Ser Gly Thr Gly Lys Thr Tyr Leu Ala Asn Arg Leu Ser
            2100                2105                2110        
Glu Tyr Ile Val Leu Arg Glu Gly Arg Glu Leu Thr Asp Gly Val Ile
        2115                2120                2125            
Ala Thr Phe Asn Val Asp His Lys Ser Ser Lys Glu Leu Arg Gln Tyr
    2130                2135                2140                
Leu Ser Asn Leu Ala Asp Gln Cys Asn Ser Glu Asn Asn Ala Val Asp
2145                2150                2155                2160
Met Pro Leu Val Ile Ile Leu Asp Asn Leu His His Val Ser Ser Leu
                2165                2170                2175    
Gly Glu Ile Phe Asn Gly Leu Leu Asn Cys Lys Tyr His Lys Cys Pro
            2180                2185                2190        
Tyr Ile Ile Gly Thr Met Asn Gln Ala Thr Ser Ser Thr Pro Asn Leu
        2195                2200                2205            
Gln Leu His His Asn Phe Arg Trp Val Leu Cys Ala Asn His Thr Glu
    2210                2215                2220                
Pro Val Lys Gly Phe Leu Gly Arg Phe Leu Arg Arg Lys Leu Met Glu
2225                2230                2235                2240
Thr Glu Ile Ser Gly Arg Val Arg Asn Met Glu Leu Val Lys Ile Ile
                2245                2250                2255    
Asp Trp Ile Pro Lys Val Trp His His Leu Asn Arg Phe Leu Glu Ala
            2260                2265                2270        
His Ser Ser Ser Asp Val Thr Ile Gly Pro Arg Leu Phe Leu Ser Cys
        2275                2280                2285            
Pro Ile Asp Val Asp Gly Ser Arg Val Trp Phe Thr Asp Leu Trp Asn
    2290                2295                2300                
Tyr Ser Ile Ile Pro Tyr Leu Leu Glu Ala Val Arg Glu Gly Leu Gln
2305                2310                2315                2320
Leu Tyr Gly Arg Arg Ala Pro Trp Glu Asp Pro Ala Lys Trp Val Met
                2325                2330                2335    
Asp Thr Tyr Pro Trp Ala Ala Ser Pro Gln Gln His Glu Trp Pro Pro
            2340                2345                2350        
Leu Leu Gln Leu Arg Pro Glu Asp Val Gly Phe Asp Gly Tyr Ser Met
        2355                2360                2365            
Pro Arg Glu Gly Ser Thr Ser Lys Gln Met Pro Pro Ser Asp Ala Glu
    2370                2375                2380                
Gly Asp Pro Leu Met Asn Met Leu Met Arg Leu Gln Glu Ala Ala Asn
2385                2390                2395                2400
Tyr Ser Ser Pro Gln Ser Tyr Asp Ser Asp Ser Asn Ser Asn Ser His
                2405                2410                2415    
His Asp Asp Ile Leu Asp Ser Ser Leu Glu Ser Thr Leu
            2420                2425                


<210> 5558
<211> 761
<212> PRT
<213> Homo sapiens

<400> 5558
Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr
 1               5                  10                  15      
Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser
            20                  25                  30          
Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys
        35                  40                  45              
Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro
    50                  55                  60                  
Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr
65                  70                  75                  80  
Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys
                85                  90                  95      
Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val
            100                 105                 110         
Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu
        115                 120                 125             
Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser
    130                 135                 140                 
Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu
145                 150                 155                 160 
Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile
                165                 170                 175     
Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg
            180                 185                 190         
Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val
        195                 200                 205             
Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr
    210                 215                 220                 
Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe
225                 230                 235                 240 
Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln
                245                 250                 255     
Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu
            260                 265                 270         
Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile
        275                 280                 285             
Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val
    290                 295                 300                 
Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu
305                 310                 315                 320 
Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile
                325                 330                 335     
Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu
            340                 345                 350         
Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser
        355                 360                 365             
Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile
    370                 375                 380                 
Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu
385                 390                 395                 400 
Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr
                405                 410                 415     
Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro
            420                 425                 430         
Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser
        435                 440                 445             
Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu
    450                 455                 460                 
Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr
465                 470                 475                 480 
Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln
                485                 490                 495     
Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser
            500                 505                 510         
Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val
        515                 520                 525             
Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val
    530                 535                 540                 
Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile
545                 550                 555                 560 
Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu
                565                 570                 575     
Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu
            580                 585                 590         
Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser
        595                 600                 605             
Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu
    610                 615                 620                 
Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys Asn Ile Ala Gln Asn His
625                 630                 635                 640 
Cys Cys Asn Met Phe Gln Ala Gly Leu His Asn Ala Leu Met Lys Asn
                645                 650                 655     
Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val
            660                 665                 670         
Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro
        675                 680                 685             
Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu
    690                 695                 700                 
Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala
705                 710                 715                 720 
Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala
                725                 730                 735     
Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe
            740                 745                 750         
Ser Ala Val Thr Leu Leu Leu Leu Cys
        755                 760     


<210> 5559
<211> 604
<212> PRT
<213> Homo sapiens

<400> 5559
Ala Arg Gly Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser
 1               5                  10                  15      
Gln Leu Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile
            20                  25                  30          
Cys Ile Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu
        35                  40                  45              
Lys Val Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala
    50                  55                  60                  
Met Glu Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp
65                  70                  75                  80  
Pro Ile Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser
                85                  90                  95      
Glu Glu Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp
            100                 105                 110         
Gly His Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu
        115                 120                 125             
Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser
    130                 135                 140                 
Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr
145                 150                 155                 160 
Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn
                165                 170                 175     
Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile
            180                 185                 190         
Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn
        195                 200                 205             
Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro
    210                 215                 220                 
Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg
225                 230                 235                 240 
Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro
                245                 250                 255     
Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln
            260                 265                 270         
Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys
        275                 280                 285             
Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys
    290                 295                 300                 
Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val
305                 310                 315                 320 
Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn
                325                 330                 335     
Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln
            340                 345                 350         
Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly
        355                 360                 365             
Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly
    370                 375                 380                 
Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser
385                 390                 395                 400 
Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met
                405                 410                 415     
Leu Lys Ser Leu Asp Trp Asn Ala Asp Tyr Glu Val Tyr Val Val Ala
            420                 425                 430         
Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr
        435                 440                 445             
Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly
    450                 455                 460                 
Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu
465                 470                 475                 480 
Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly
                485                 490                 495     
Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly
            500                 505                 510         
Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp
        515                 520                 525             
Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr
    530                 535                 540                 
Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro
545                 550                 555                 560 
Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln
                565                 570                 575     
Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn
            580                 585                 590         
Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala
        595                 600                 


<210> 5560
<211> 848
<212> PRT
<213> Homo sapiens

<400> 5560
Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr
 1               5                  10                  15      
Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser
            20                  25                  30          
Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys
        35                  40                  45              
Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro
    50                  55                  60                  
Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr
65                  70                  75                  80  
Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys
                85                  90                  95      
Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val
            100                 105                 110         
Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu
        115                 120                 125             
Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser
    130                 135                 140                 
Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu
145                 150                 155                 160 
Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile
                165                 170                 175     
Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg
            180                 185                 190         
Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val
        195                 200                 205             
Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr
    210                 215                 220                 
Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe
225                 230                 235                 240 
Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln
                245                 250                 255     
Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu
            260                 265                 270         
Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile
        275                 280                 285             
Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val
    290                 295                 300                 
Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu
305                 310                 315                 320 
Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile
                325                 330                 335     
Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu
            340                 345                 350         
Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser
        355                 360                 365             
Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile
    370                 375                 380                 
Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu
385                 390                 395                 400 
Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr
                405                 410                 415     
Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro
            420                 425                 430         
Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser
        435                 440                 445             
Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu
    450                 455                 460                 
Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr
465                 470                 475                 480 
Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln
                485                 490                 495     
Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser
            500                 505                 510         
Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val
        515                 520                 525             
Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val
    530                 535                 540                 
Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile
545                 550                 555                 560 
Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu
                565                 570                 575     
Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu
            580                 585                 590         
Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu
        595                 600                 605             
Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys
    610                 615                 620                 
Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg
625                 630                 635                 640 
Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser
                645                 650                 655     
Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val
            660                 665                 670         
Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe
        675                 680                 685             
Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser
    690                 695                 700                 
Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val
705                 710                 715                 720 
Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu
                725                 730                 735     
Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys
            740                 745                 750         
Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala
        755                 760                 765             
Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu
    770                 775                 780                 
Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn
785                 790                 795                 800 
Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys
                805                 810                 815     
Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys
            820                 825                 830         
Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala
        835                 840                 845             


<210> 5561
<211> 761
<212> PRT
<213> Homo sapiens

<400> 5561
Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr
 1               5                  10                  15      
Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser
            20                  25                  30          
Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys
        35                  40                  45              
Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro
    50                  55                  60                  
Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr
65                  70                  75                  80  
Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys
                85                  90                  95      
Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val
            100                 105                 110         
Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu
        115                 120                 125             
Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser
    130                 135                 140                 
Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu
145                 150                 155                 160 
Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile
                165                 170                 175     
Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg
            180                 185                 190         
Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val
        195                 200                 205             
Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr
    210                 215                 220                 
Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe
225                 230                 235                 240 
Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln
                245                 250                 255     
Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu
            260                 265                 270         
Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile
        275                 280                 285             
Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val
    290                 295                 300                 
Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu
305                 310                 315                 320 
Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile
                325                 330                 335     
Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu
            340                 345                 350         
Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser
        355                 360                 365             
Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile
    370                 375                 380                 
Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu
385                 390                 395                 400 
Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr
                405                 410                 415     
Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro
            420                 425                 430         
Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser
        435                 440                 445             
Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu
    450                 455                 460                 
Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr
465                 470                 475                 480 
Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln
                485                 490                 495     
Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser
            500                 505                 510         
Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val
        515                 520                 525             
Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val
    530                 535                 540                 
Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile
545                 550                 555                 560 
Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu
                565                 570                 575     
Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu
            580                 585                 590         
Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser
        595                 600                 605             
Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu
    610                 615                 620                 
Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys Gly Glu Pro Ser Ala Pro
625                 630                 635                 640 
Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn
                645                 650                 655     
Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val
            660                 665                 670         
Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro
        675                 680                 685             
Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu
    690                 695                 700                 
Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala
705                 710                 715                 720 
Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala
                725                 730                 735     
Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe
            740                 745                 750         
Ser Ala Val Thr Leu Leu Leu Leu Cys
        755                 760     


<210> 5562
<211> 375
<212> PRT
<213> Homo sapiens

<400> 5562
Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His
 1               5                  10                  15      
Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe
            20                  25                  30          
Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala
        35                  40                  45              
Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu
    50                  55                  60                  
Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg
65                  70                  75                  80  
Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val
                85                  90                  95      
Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val
            100                 105                 110         
Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile
        115                 120                 125             
Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu
    130                 135                 140                 
Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp
145                 150                 155                 160 
Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser
                165                 170                 175     
Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala
            180                 185                 190         
Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly
        195                 200                 205             
Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile
    210                 215                 220                 
Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val
225                 230                 235                 240 
Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu
                245                 250                 255     
Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys
            260                 265                 270         
Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu
        275                 280                 285             
Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu
    290                 295                 300                 
Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu
305                 310                 315                 320 
Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr
                325                 330                 335     
Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys
            340                 345                 350         
Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu
        355                 360                 365             
Gln Gly Ala Arg Gly Phe Ala
    370                 375 


<210> 5563
<211> 529
<212> PRT
<213> Homo sapiens

<400> 5563
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu
 1               5                  10                  15      
Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met
            20                  25                  30          
Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala
        35                  40                  45              
Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser
    50                  55                  60                  
Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr
65                  70                  75                  80  
Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu
                85                  90                  95      
Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu
            100                 105                 110         
Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp
        115                 120                 125             
Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys
    130                 135                 140                 
Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu
145                 150                 155                 160 
Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu
                165                 170                 175     
Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu
            180                 185                 190         
Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr
        195                 200                 205             
Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr
    210                 215                 220                 
Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly
225                 230                 235                 240 
Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser
                245                 250                 255     
Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp
            260                 265                 270         
Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu
        275                 280                 285             
Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu
    290                 295                 300                 
Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln
305                 310                 315                 320 
Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln
                325                 330                 335     
Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr
            340                 345                 350         
Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly
        355                 360                 365             
Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu
    370                 375                 380                 
Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly
385                 390                 395                 400 
Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly
                405                 410                 415     
Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu
            420                 425                 430         
Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly
        435                 440                 445             
Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val
    450                 455                 460                 
Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser
465                 470                 475                 480 
Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu
                485                 490                 495     
Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg
            500                 505                 510         
Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala
        515                 520                 525             
Ala
    


<210> 5564
<211> 5405
<212> PRT
<213> Homo sapiens

<400> 5564
Met Gly Ala Leu Trp Ser Trp Trp Ile Leu Trp Ala Gly Ala Thr Leu
 1               5                  10                  15      
Leu Trp Gly Leu Thr Gln Glu Ala Ser Val Asp Leu Lys Asn Thr Gly
            20                  25                  30          
Arg Glu Glu Phe Leu Thr Ala Phe Leu Gln Asn Tyr Gln Leu Ala Tyr
        35                  40                  45              
Ser Lys Ala Tyr Pro Arg Leu Leu Ile Ser Ser Leu Ser Glu Ser Pro
    50                  55                  60                  
Ala Ser Val Ser Ile Leu Ser Gln Ala Asp Asn Thr Ser Lys Lys Val
65                  70                  75                  80  
Thr Val Arg Pro Gly Glu Ser Val Met Val Asn Ile Ser Ala Lys Ala
                85                  90                  95      
Glu Met Ile Gly Ser Lys Ile Phe Gln His Ala Val Val Ile His Ser
            100                 105                 110         
Asp Tyr Ala Ile Ser Val Gln Ala Leu Asn Ala Lys Pro Asp Thr Ala
        115                 120                 125             
Glu Leu Thr Leu Leu Arg Pro Ile Gln Ala Leu Gly Thr Glu Tyr Phe
    130                 135                 140                 
Val Leu Thr Pro Pro Gly Thr Ser Ala Arg Asn Val Lys Glu Phe Ala
145                 150                 155                 160 
Val Val Ala Gly Ala Ala Gly Ala Ser Val Ser Val Thr Leu Lys Gly
                165                 170                 175     
Ser Val Thr Phe Asn Gly Lys Phe Tyr Pro Ala Gly Asp Val Leu Arg
            180                 185                 190         
Val Thr Leu Gln Pro Tyr Asn Val Ala Gln Leu Gln Ser Ser Val Asp
        195                 200                 205             
Leu Ser Gly Ser Lys Val Thr Ala Ser Ser Pro Val Ala Val Leu Ser
    210                 215                 220                 
Gly His Ser Cys Ala Gln Lys His Thr Thr Cys Asn His Val Val Glu
225                 230                 235                 240 
Gln Leu Leu Pro Thr Ser Ala Trp Gly Thr His Tyr Val Val Pro Thr
                245                 250                 255     
Leu Ala Ser Gln Ser Arg Tyr Asp Leu Ala Phe Val Val Ala Ser Gln
            260                 265                 270         
Ala Thr Lys Leu Thr Tyr Asn His Gly Gly Ile Thr Gly Ser Arg Gly
        275                 280                 285             
Leu Gln Ala Gly Asp Val Val Glu Phe Glu Val Arg Pro Ser Trp Pro
    290                 295                 300                 
Leu Tyr Leu Ser Ala Asn Val Gly Ile Gln Val Leu Leu Phe Gly Thr
305                 310                 315                 320 
Gly Ala Ile Arg Asn Glu Val Thr Tyr Asp Pro Tyr Leu Val Leu Ile
                325                 330                 335     
Pro Asp Val Ala Ala Tyr Cys Pro Ala Tyr Val Val Lys Ser Val Pro
            340                 345                 350         
Gly Cys Glu Gly Val Ala Leu Val Val Ala Gln Thr Lys Ala Ile Ser
        355                 360                 365             
Gly Leu Thr Ile Asp Gly His Ala Val Gly Ala Lys Leu Thr Trp Glu
    370                 375                 380                 
Ala Val Pro Gly Ser Glu Phe Ser Tyr Ala Glu Val Glu Leu Gly Thr
385                 390                 395                 400 
Ala Asp Met Ile His Thr Ala Glu Ala Thr Thr Asn Leu Gly Leu Leu
                405                 410                 415     
Thr Phe Gly Leu Ala Lys Ala Ile Gly Tyr Ala Thr Ala Ala Asp Cys
            420                 425                 430         
Gly Arg Thr Val Leu Ser Pro Val Glu Pro Ser Cys Glu Gly Met Gln
        435                 440                 445             
Cys Ala Ala Gly Gln Arg Cys Gln Val Val Gly Gly Lys Ala Gly Cys
    450                 455                 460                 
Val Ala Glu Ser Thr Ala Val Cys Arg Ala Gln Gly Asp Pro His Tyr
465                 470                 475                 480 
Thr Thr Phe Asp Gly Arg Arg Tyr Asp Met Met Gly Thr Cys Ser Tyr
                485                 490                 495     
Thr Met Val Glu Leu Cys Ser Glu Asp Asp Thr Leu Pro Ala Phe Ser
            500                 505                 510         
Val Glu Ala Lys Asn Glu His Arg Gly Ser Arg Arg Val Ser Tyr Val
        515                 520                 525             
Gly Leu Val Thr Val Arg Ala Tyr Ser His Ser Val Ser Leu Thr Arg
    530                 535                 540                 
Gly Glu Val Gly Phe Val Leu Val Asp Asn Gln Arg Ser Arg Leu Pro
545                 550                 555                 560 
Val Ser Leu Ser Glu Gly Arg Leu Arg Val Tyr Gln Ser Gly Pro Arg
                565                 570                 575     
Ala Val Val Glu Leu Val Phe Gly Leu Val Val Thr Tyr Asp Trp Asp
            580                 585                 590         
Cys Gln Leu Ala Leu Ser Leu Pro Ala Arg Phe Gln Asp Gln Val Cys
        595                 600                 605             
Gly Leu Cys Gly Asn Tyr Asn Gly Asp Pro Ala Asp Asp Phe Leu Thr
    610                 615                 620                 
Pro Asp Gly Ala Leu Ala Pro Asp Ala Val Glu Phe Ala Ser Ser Trp
625                 630                 635                 640 
Lys Leu Asp Asp Gly Asp Tyr Leu Cys Glu Asp Gly Cys Gln Asn Asn
                645                 650                 655     
Cys Pro Ala Cys Thr Pro Gly Gln Ala Gln His Tyr Glu Gly Asp Arg
            660                 665                 670         
Leu Cys Gly Met Leu Thr Lys Leu Asp Gly Pro Phe Ala Val Cys His
        675                 680                 685             
Asp Thr Leu Asp Pro Arg Pro Phe Leu Glu Gln Cys Val Tyr Asp Leu
    690                 695                 700                 
Cys Val Val Gly Gly Glu Arg Leu Ser Leu Cys Arg Gly Leu Ser Ala
705                 710                 715                 720 
Tyr Ala Gln Ala Cys Leu Glu Leu Gly Ile Ser Val Gly Asp Trp Arg
                725                 730                 735     
Ser Pro Ala Asn Cys Pro Leu Ser Cys Pro Ala Asn Ser Arg Tyr Glu
            740                 745                 750         
Leu Cys Gly Pro Ala Cys Pro Thr Ser Cys Asn Gly Ala Ala Ala Pro
        755                 760                 765             
Ser Asn Cys Ser Gly Arg Pro Cys Val Glu Gly Cys Val Cys Leu Pro
    770                 775                 780                 
Gly Phe Val Ala Ser Gly Gly Ala Cys Val Pro Ala Ser Ser Cys Gly
785                 790                 795                 800 
Cys Thr Phe Gln Gly Leu Gln Leu Ala Pro Gly Gln Glu Val Trp Ala
                805                 810                 815     
Asp Glu Leu Cys Gln Arg Arg Cys Thr Cys Asn Gly Ala Thr His Gln
            820                 825                 830         
Val Thr Cys Arg Asp Lys Gln Ser Cys Pro Ala Gly Glu Arg Cys Ser
        835                 840                 845             
Val Gln Asn Gly Leu Leu Gly Cys Tyr Pro Asp Arg Phe Gly Thr Cys
    850                 855                 860                 
Gln Gly Ser Gly Asp Pro His Tyr Val Ser Phe Asp Gly Arg Arg Phe
865                 870                 875                 880 
Asp Phe Met Gly Thr Cys Thr Tyr Leu Leu Val Gly Ser Cys Gly Gln
                885                 890                 895     
Asn Ala Ala Leu Pro Ala Phe Arg Val Leu Val Glu Asn Glu His Arg
            900                 905                 910         
Gly Ser Gln Thr Val Ser Tyr Thr Arg Ala Val Arg Val Glu Ala Arg
        915                 920                 925             
Gly Val Lys Val Ala Val Arg Arg Glu Tyr Pro Gly Gln Val Leu Val
    930                 935                 940                 
Asp Asp Val Leu Gln Tyr Leu Pro Phe Gln Ala Ala Asp Gly Gln Val
945                 950                 955                 960 
Gln Val Phe Arg Gln Gly Arg Asp Ala Val Val Arg Thr Asp Phe Gly
                965                 970                 975     
Leu Thr Val Thr Tyr Asp Trp Asn Ala Arg Val Thr Ala Lys Val Pro
            980                 985                 990         
Ser Ser Tyr Ala Glu Ala Leu Cys Gly Leu Cys Gly Asn Phe Asn Gly
        995                 1000                1005            
Asp Pro Ala Asp Asp Leu Ala Leu Arg Gly Gly Gly Gln Ala Ala Asn
    1010                1015                1020                
Ala Leu Ala Phe Gly Asn Ser Trp Gln Glu Glu Thr Arg Pro Gly Cys
1025                1030                1035                1040
Gly Ala Thr Glu Pro Gly Asp Cys Pro Lys Leu Asp Ser Leu Val Ala
                1045                1050                1055    
Gln Gln Leu Gln Ser Lys Asn Glu Cys Gly Ile Leu Ala Asp Pro Lys
            1060                1065                1070        
Gly Pro Phe Arg Glu Cys His Ser Lys Leu Asp Pro Gln Gly Ala Val
        1075                1080                1085            
Arg Asp Cys Val Tyr Asp Arg Cys Leu Leu Pro Gly Gln Ser Gly Pro
    1090                1095                1100                
Leu Cys Asp Ala Leu Ala Thr Tyr Ala Ala Ala Cys Gln Ala Ala Gly
1105                1110                1115                1120
Ala Thr Val His Pro Trp Arg Ser Glu Glu Leu Cys Pro Leu Ser Cys
                1125                1130                1135    
Pro Pro His Ser His Tyr Glu Ala Cys Ser Tyr Gly Cys Pro Leu Ser
            1140                1145                1150        
Cys Gly Asp Leu Pro Val Pro Gly Gly Cys Gly Ser Glu Cys His Glu
        1155                1160                1165            
Gly Cys Val Cys Asp Glu Gly Phe Ala Leu Ser Gly Glu Ser Cys Leu
    1170                1175                1180                
Pro Leu Ala Ser Cys Gly Cys Val His Gln Gly Thr Tyr His Pro Pro
1185                1190                1195                1200
Gly Gln Thr Phe Tyr Pro Gly Pro Gly Cys Asp Ser Leu Cys His Cys
                1205                1210                1215    
Gln Glu Gly Gly Leu Val Ser Cys Glu Ser Ser Ser Cys Gly Pro His
            1220                1225                1230        
Glu Ala Cys Gln Pro Ser Gly Gly Ser Leu Gly Cys Val Ala Val Gly
        1235                1240                1245            
Ser Ser Thr Cys Gln Ala Ser Gly Asp Pro His Tyr Thr Thr Phe Asp
    1250                1255                1260                
Gly Arg Arg Phe Asp Phe Met Gly Thr Cys Val Tyr Val Leu Ala Gln
1265                1270                1275                1280
Thr Cys Gly Thr Arg Pro Gly Leu His Arg Phe Ala Val Leu Gln Glu
                1285                1290                1295    
Asn Val Ala Trp Gly Asn Gly Arg Val Ser Val Thr Arg Val Ile Thr
            1300                1305                1310        
Val Gln Val Ala Asn Phe Thr Leu Arg Leu Glu Gln Arg Gln Trp Lys
        1315                1320                1325            
Val Thr Val Asn Gly Val Asp Met Lys Leu Pro Val Val Leu Ala Asn
    1330                1335                1340                
Gly Gln Ile Arg Ala Ser Gln His Gly Ser Asp Val Val Ile Glu Thr
1345                1350                1355                1360
Asp Phe Gly Leu Arg Val Ala Tyr Asp Leu Val Tyr Tyr Val Arg Val
                1365                1370                1375    
Thr Val Pro Gly Asn Tyr Tyr Gln Gln Met Cys Gly Leu Cys Gly Asn
            1380                1385                1390        
Tyr Asn Gly Asp Pro Lys Asp Asp Phe Gln Lys Pro Asn Gly Ser Gln
        1395                1400                1405            
Ala Gly Asn Ala Asn Glu Phe Gly Asn Ser Trp Glu Glu Val Val Pro
    1410                1415                1420                
Asp Ser Pro Cys Leu Pro Pro Thr Pro Cys Pro Pro Gly Ser Glu Asp
1425                1430                1435                1440
Cys Ile Pro Ser His Lys Cys Pro Pro Glu Leu Glu Lys Lys Tyr Gln
                1445                1450                1455    
Lys Glu Glu Phe Cys Gly Leu Leu Ser Ser Pro Thr Gly Pro Leu Ser
            1460                1465                1470        
Ser Cys His Lys Leu Val Asp Pro Gln Gly Pro Leu Lys Asp Cys Ile
        1475                1480                1485            
Phe Asp Leu Cys Leu Gly Gly Gly Asn Leu Ser Ile Leu Cys Ser Asn
    1490                1495                1500                
Ile His Ala Tyr Val Ser Ala Cys Gln Ala Ala Gly Gly His Val Glu
1505                1510                1515                1520
Pro Trp Arg Thr Glu Thr Phe Cys Pro Met Glu Cys Pro Pro Asn Ser
                1525                1530                1535    
His Tyr Glu Leu Cys Ala Asp Thr Cys Ser Leu Gly Cys Ser Ala Leu
            1540                1545                1550        
Ser Ala Pro Pro Gln Cys Gln Asp Gly Cys Ala Glu Gly Cys Gln Cys
        1555                1560                1565            
Asp Ser Gly Phe Leu Tyr Asn Gly Gln Ala Cys Val Pro Ile Gln Gln
    1570                1575                1580                
Cys Gly Cys Tyr His Asn Gly Val Tyr Tyr Glu Pro Glu Gln Thr Val
1585                1590                1595                1600
Leu Ile Asp Asn Cys Arg Gln Gln Cys Thr Cys His Ala Gly Lys Gly
                1605                1610                1615    
Met Val Cys Gln Glu His Ser Cys Lys Pro Gly Gln Val Cys Gln Pro
            1620                1625                1630        
Ser Gly Gly Ile Leu Ser Cys Val Thr Lys Asp Pro Cys His Gly Val
        1635                1640                1645            
Thr Cys Arg Pro Gln Glu Thr Cys Lys Glu Gln Gly Gly Gln Gly Val
    1650                1655                1660                
Cys Leu Pro Asn Tyr Glu Ala Thr Cys Trp Leu Trp Gly Asp Pro His
1665                1670                1675                1680
Tyr His Ser Phe Asp Gly Arg Lys Phe Asp Phe Gln Gly Thr Cys Asn
                1685                1690                1695    
Tyr Val Leu Ala Thr Thr Gly Cys Pro Gly Val Ser Thr Gln Gly Leu
            1700                1705                1710        
Thr Pro Phe Thr Val Thr Thr Lys Asn Gln Asn Arg Gly Asn Pro Ala
        1715                1720                1725            
Val Ser Tyr Val Arg Val Val Thr Val Ala Ala Leu Gly Thr Asn Ile
    1730                1735                1740                
Ser Ile His Lys Asp Glu Ile Gly Lys Val Arg Val Asn Gly Val Leu
1745                1750                1755                1760
Thr Ala Leu Pro Val Ser Val Ala Asp Gly Arg Ile Ser Val Thr Gln
                1765                1770                1775    
Gly Ala Ser Lys Ala Leu Leu Val Ala Asp Phe Gly Leu Gln Val Ser
            1780                1785                1790        
Tyr Asp Trp Asn Trp Arg Val Asp Val Thr Leu Pro Ser Ser Tyr His
        1795                1800                1805            
Gly Ala Val Cys Gly Leu Cys Gly Asn Met Asp Arg Asn Pro Asn Asn
    1810                1815                1820                
Asp Gln Val Phe Pro Asn Gly Thr Leu Ala Pro Ser Ile Pro Ile Trp
1825                1830                1835                1840
Gly Gly Ser Trp Arg Ala Pro Gly Trp Asp Pro Leu Cys Trp Asp Glu
                1845                1850                1855    
Cys Arg Gly Ser Cys Pro Thr Cys Pro Glu Asp Arg Leu Glu Gln Tyr
            1860                1865                1870        
Glu Gly Pro Gly Phe Cys Gly Pro Leu Ala Pro Gly Thr Gly Gly Pro
        1875                1880                1885            
Phe Thr Thr Cys His Ala His Val Pro Pro Glu Ser Phe Phe Lys Gly
    1890                1895                1900                
Cys Val Leu Asp Val Cys Met Gly Gly Gly Asp Arg Asp Ile Leu Cys
1905                1910                1915                1920
Lys Ala Leu Ala Ser Tyr Val Ala Ala Cys Gln Ala Ala Gly Val Val
                1925                1930                1935    
Ile Glu Asp Trp Arg Ala Gln Val Gly Cys Glu Ile Thr Cys Pro Glu
            1940                1945                1950        
Asn Ser His Tyr Glu Val Cys Gly Pro Pro Cys Pro Ala Ser Cys Pro
        1955                1960                1965            
Ser Pro Ala Pro Leu Thr Thr Pro Ala Val Cys Glu Gly Pro Cys Val
    1970                1975                1980                
Glu Gly Cys Gln Cys Asp Ala Gly Phe Val Leu Ser Ala Asp Arg Cys
1985                1990                1995                2000
Val Pro Leu Asn Asn Gly Cys Gly Cys Trp Ala Asn Gly Thr Tyr His
                2005                2010                2015    
Glu Ala Gly Ser Glu Phe Trp Ala Asp Gly Thr Cys Ser Gln Trp Cys
            2020                2025                2030        
Arg Cys Gly Pro Gly Gly Gly Ser Leu Val Cys Thr Pro Ala Ser Cys
        2035                2040                2045            
Gly Leu Gly Glu Val Cys Gly Leu Leu Pro Ser Gly Gln His Gly Cys
    2050                2055                2060                
Gln Pro Val Ser Thr Ala Glu Cys Gln Ala Trp Gly Asp Pro His Tyr
2065                2070                2075                2080
Val Thr Leu Asp Gly His Arg Phe Asn Phe Gln Gly Thr Cys Glu Tyr
                2085                2090                2095    
Leu Leu Ser Ala Pro Cys His Gly Pro Pro Leu Gly Ala Glu Asn Phe
            2100                2105                2110        
Thr Val Thr Val Ala Asn Glu His Arg Gly Ser Gln Ala Val Ser Tyr
        2115                2120                2125            
Thr Arg Ser Val Thr Leu Gln Ile Tyr Asn His Ser Leu Thr Leu Ser
    2130                2135                2140                
Ala Arg Trp Pro Arg Lys Leu Gln Val Asp Gly Val Phe Val Thr Leu
2145                2150                2155                2160
Pro Phe Gln Leu Asp Ser Leu Leu His Ala His Leu Ser Gly Ala Asp
                2165                2170                2175    
Val Val Val Thr Thr Thr Ser Gly Leu Ser Leu Ala Phe Asp Gly Asp
            2180                2185                2190        
Ser Phe Val Arg Leu Arg Val Pro Ala Ala Tyr Ala Gly Ser Leu Cys
        2195                2200                2205            
Gly Leu Cys Gly Asn Tyr Asn Gln Asp Pro Ala Asp Asp Leu Lys Ala
    2210                2215                2220                
Val Gly Gly Lys Pro Ala Gly Trp Gln Val Gly Gly Ala Gln Gly Cys
2225                2230                2235                2240
Gly Glu Cys Val Ser Lys Pro Cys Pro Ser Pro Cys Thr Pro Glu Gln
                2245                2250                2255    
Gln Glu Ser Phe Gly Gly Pro Asp Ala Cys Gly Val Ile Ser Ala Thr
            2260                2265                2270        
Asp Gly Pro Leu Ala Pro Cys His Gly Leu Val Pro Pro Ala Gln Tyr
        2275                2280                2285            
Phe Gln Gly Cys Leu Leu Asp Ala Cys Gln Val Gln Gly His Pro Gly
    2290                2295                2300                
Gly Leu Cys Pro Ala Val Ala Thr Tyr Val Ala Ala Cys Gln Ala Ala
2305                2310                2315                2320
Gly Ala Gln Leu Arg Glu Trp Arg Arg Pro Asp Phe Cys Pro Phe Gln
                2325                2330                2335    
Cys Pro Ala His Ser His Tyr Glu Leu Cys Gly Asp Ser Cys Pro Gly
            2340                2345                2350        
Ser Cys Pro Ser Leu Ser Ala Pro Glu Gly Cys Glu Ser Ala Cys Arg
        2355                2360                2365            
Glu Gly Cys Val Cys Asp Ala Gly Phe Val Leu Ser Gly Asp Thr Cys
    2370                2375                2380                
Val Pro Val Gly Gln Cys Gly Cys Leu His Asp Asp Arg Tyr Tyr Pro
2385                2390                2395                2400
Leu Gly Gln Thr Phe Tyr Pro Gly Pro Gly Cys Asp Ser Leu Cys Arg
                2405                2410                2415    
Cys Arg Glu Gly Gly Glu Val Ser Cys Glu Pro Ser Ser Cys Gly Pro
            2420                2425                2430        
His Glu Thr Cys Arg Pro Ser Gly Gly Ser Leu Gly Cys Val Ala Val
        2435                2440                2445            
Gly Ser Thr Thr Cys Gln Ala Ser Gly Asp Pro His Tyr Thr Thr Phe
    2450                2455                2460                
Asp Gly Arg Arg Phe Asp Phe Met Gly Thr Cys Val Tyr Val Leu Ala
2465                2470                2475                2480
Gln Thr Cys Gly Thr Arg Pro Gly Leu His Arg Phe Ala Val Leu Gln
                2485                2490                2495    
Glu Asn Val Ala Trp Gly Asn Gly Arg Val Ser Val Thr Arg Val Ile
            2500                2505                2510        
Thr Val Gln Val Ala Asn Phe Thr Leu Arg Leu Glu Gln Arg Gln Trp
        2515                2520                2525            
Lys Val Thr Val Asn Gly Val Asp Met Lys Leu Pro Val Val Leu Ala
    2530                2535                2540                
Asn Gly Gln Ile Arg Ala Ser Gln His Gly Ser Asp Val Val Ile Glu
2545                2550                2555                2560
Thr Asp Phe Gly Leu Arg Val Ala Tyr Asp Leu Val Tyr Tyr Val Arg
                2565                2570                2575    
Val Thr Val Pro Gly Asn Tyr Tyr Gln Leu Met Cys Gly Leu Cys Gly
            2580                2585                2590        
Asn Tyr Asn Gly Asp Pro Lys Asp Asp Phe Gln Lys Pro Asn Gly Ser
        2595                2600                2605            
Gln Ala Gly Asn Ala Asn Glu Phe Gly Asn Ser Trp Glu Glu Val Val
    2610                2615                2620                
Pro Asp Ser Pro Cys Leu Pro Pro Pro Thr Cys Pro Pro Gly Ser Glu
2625                2630                2635                2640
Gly Cys Ile Pro Ser Glu Glu Cys Pro Pro Glu Leu Glu Lys Lys Tyr
                2645                2650                2655    
Gln Lys Glu Glu Phe Cys Gly Leu Leu Ser Ser Pro Thr Gly Pro Leu
            2660                2665                2670        
Ser Ser Cys His Lys Leu Val Asp Pro Gln Gly Pro Leu Lys Asp Cys
        2675                2680                2685            
Ile Phe Asp Leu Cys Leu Gly Gly Gly Asn Leu Ser Ile Leu Cys Ser
    2690                2695                2700                
Asn Ile His Ala Tyr Val Ser Ala Cys Gln Ala Ala Gly Gly His Val
2705                2710                2715                2720
Glu Pro Trp Arg Asn Glu Thr Phe Cys Pro Met Glu Cys Pro Gln Asn
                2725                2730                2735    
Ser His Tyr Glu Leu Cys Ala Asp Thr Cys Ser Leu Gly Cys Ser Ala
            2740                2745                2750        
Leu Ser Ala Pro Leu Gln Cys Pro Asp Gly Cys Ala Glu Gly Cys Gln
        2755                2760                2765            
Cys Asp Ser Gly Phe Leu Tyr Asn Gly Gln Ala Cys Val Pro Ile Gln
    2770                2775                2780                
Gln Cys Gly Cys Tyr His Asn Gly Ala Tyr Tyr Glu Pro Glu Gln Thr
2785                2790                2795                2800
Val Leu Ile Asp Asn Cys Arg Gln Gln Cys Thr Cys His Ala Gly Lys
                2805                2810                2815    
Val Val Val Cys Gln Glu His Ser Cys Lys Pro Gly Gln Val Cys Gln
            2820                2825                2830        
Pro Ser Gly Gly Ile Leu Ser Cys Val Thr Lys Asp Pro Cys His Gly
        2835                2840                2845            
Val Thr Cys Arg Pro Gln Glu Thr Cys Lys Glu Gln Gly Gly Gln Gly
    2850                2855                2860                
Val Cys Leu Pro Asn Tyr Glu Ala Thr Cys Trp Leu Trp Gly Asp Pro
2865                2870                2875                2880
His Tyr His Ser Phe Asp Gly Arg Lys Phe Asp Phe Gln Gly Thr Cys
                2885                2890                2895    
Asn Tyr Val Leu Ala Thr Thr Gly Cys Pro Gly Val Ser Thr Gln Gly
            2900                2905                2910        
Leu Thr Pro Phe Thr Val Thr Thr Lys Asn Gln Asn Arg Gly Asn Pro
        2915                2920                2925            
Ala Val Ser Tyr Val Arg Val Val Thr Val Ala Ala Leu Gly Thr Asn
    2930                2935                2940                
Ile Ser Ile His Lys Asp Glu Ile Gly Lys Val Arg Val Asn Gly Val
2945                2950                2955                2960
Leu Thr Ala Leu Pro Val Ser Val Ala Asp Gly Arg Ile Ser Val Ala
                2965                2970                2975    
Gln Gly Ala Ser Lys Ala Leu Leu Val Ala Asp Phe Gly Leu Gln Val
            2980                2985                2990        
Ser Tyr Asp Trp Asn Trp Arg Val Asp Val Thr Leu Pro Ser Ser Tyr
        2995                3000                3005            
His Gly Ala Val Cys Gly Leu Cys Gly Asn Met Asp Arg Asn Pro Asn
    3010                3015                3020                
Asn Asp Gln Val Phe Pro Asn Gly Thr Leu Ala Pro Ser Ile Pro Ile
3025                3030                3035                3040
Trp Gly Gly Ser Trp Arg Ala Pro Gly Trp Asp Pro Leu Cys Trp Asp
                3045                3050                3055    
Glu Cys Arg Gly Ser Cys Pro Thr Cys Pro Glu Asp Arg Leu Glu Gln
            3060                3065                3070        
Tyr Glu Gly Pro Gly Phe Cys Gly Pro Leu Ala Pro Gly Thr Gly Gly
        3075                3080                3085            
Pro Phe Thr Thr Cys His Ala His Val Pro Pro Glu Ser Phe Phe Lys
    3090                3095                3100                
Gly Cys Val Leu Asp Val Cys Met Gly Gly Gly Asp His Asp Ile Leu
3105                3110                3115                3120
Cys Lys Ala Leu Ala Ser Tyr Val Ala Ala Cys Gln Ala Ala Gly Val
                3125                3130                3135    
Val Ile Glu Asp Trp Arg Ala Gln Val Gly Cys Glu Ile Thr Cys Pro
            3140                3145                3150        
Glu Asn Ser His Tyr Glu Val Cys Gly Pro Pro Cys Pro Ala Ser Cys
        3155                3160                3165            
Pro Ser Pro Ala Pro Leu Thr Thr Pro Ala Val Cys Glu Gly Pro Cys
    3170                3175                3180                
Val Glu Gly Cys Gln Cys Asp Ala Gly Phe Val Leu Ser Ala Asp Arg
3185                3190                3195                3200
Cys Val Pro Leu Asn Asn Gly Cys Gly Cys Trp Ala Asn Gly Thr Tyr
                3205                3210                3215    
His Glu Ala Gly Ser Glu Phe Trp Ala Asp Gly Thr Cys Ser Gln Trp
            3220                3225                3230        
Cys Arg Cys Gly Pro Gly Gly Gly Ser Leu Val Cys Thr Pro Ala Ser
        3235                3240                3245            
Cys Gly Leu Gly Glu Val Cys Gly Leu Leu Pro Ser Gly Gln His Gly
    3250                3255                3260                
Cys Gln Pro Val Ser Thr Ala Glu Cys Gln Ala Trp Gly Asp Pro His
3265                3270                3275                3280
Tyr Val Thr Leu Asp Gly His Arg Phe Asp Phe Gln Gly Thr Cys Glu
                3285                3290                3295    
Tyr Leu Leu Ser Ala Pro Cys His Gly Pro Pro Leu Gly Ala Glu Asn
            3300                3305                3310        
Phe Thr Val Thr Val Ala Asn Glu His Arg Gly Ser Gln Ala Val Ser
        3315                3320                3325            
Tyr Thr Arg Ser Val Thr Leu Gln Ile Tyr Asn His Ser Leu Thr Leu
    3330                3335                3340                
Ser Ala Arg Trp Pro Arg Lys Leu Gln Val Asp Gly Val Phe Val Thr
3345                3350                3355                3360
Leu Pro Phe Gln Leu Asp Ser Leu Leu His Ala His Leu Ser Gly Ala
                3365                3370                3375    
Asp Val Val Val Thr Thr Thr Ser Gly Leu Ser Leu Ala Phe Asp Gly
            3380                3385                3390        
Asp Ser Phe Val Arg Leu Arg Val Pro Ala Ala Tyr Ala Gly Ser Leu
        3395                3400                3405            
Cys Gly Leu Cys Gly Asn Tyr Asn Gln Asp Pro Ala Asp Asp Leu Lys
    3410                3415                3420                
Ala Val Gly Gly Lys Pro Ala Gly Trp Gln Val Gly Gly Ala Gln Gly
3425                3430                3435                3440
Cys Gly Glu Cys Val Ser Lys Pro Cys Pro Ser Pro Cys Thr Pro Glu
                3445                3450                3455    
Gln Gln Glu Ser Phe Gly Gly Pro Asp Ala Cys Gly Val Ile Ser Ala
            3460                3465                3470        
Thr Asp Gly Pro Leu Ala Pro Cys His Gly Leu Val Pro Pro Ala Gln
        3475                3480                3485            
Tyr Phe Gln Gly Cys Leu Leu Asp Ala Cys Gln Val Gln Gly His Pro
    3490                3495                3500                
Gly Gly Leu Cys Pro Ala Val Ala Thr Tyr Val Ala Ala Cys Gln Ala
3505                3510                3515                3520
Ala Gly Ala Gln Leu Arg Glu Trp Arg Arg Pro Asp Phe Cys Pro Phe
                3525                3530                3535    
Gln Cys Pro Ala His Ser His Tyr Glu Leu Cys Gly Asp Ser Cys Pro
            3540                3545                3550        
Gly Ser Cys Pro Ser Leu Ser Ala Pro Glu Gly Cys Glu Ser Ala Cys
        3555                3560                3565            
Arg Glu Gly Cys Val Cys Asp Ala Gly Phe Val Leu Ser Gly Asp Thr
    3570                3575                3580                
Cys Val Pro Val Gly Gln Cys Gly Cys Leu His Asp Asp Arg Tyr Tyr
3585                3590                3595                3600
Pro Leu Gly Gln Thr Phe Tyr Pro Gly Pro Gly Cys Asp Ser Leu Cys
                3605                3610                3615    
Arg Cys Arg Glu Gly Gly Glu Val Ser Cys Glu Pro Ser Ser Cys Gly
            3620                3625                3630        
Pro His Glu Thr Cys Arg Pro Ser Gly Gly Ser Leu Gly Cys Val Ala
        3635                3640                3645            
Val Gly Ser Thr Thr Cys Gln Ala Ser Gly Asp Pro His Tyr Thr Thr
    3650                3655                3660                
Phe Asp Gly Arg Arg Phe Asp Phe Met Gly Thr Cys Val Tyr Val Leu
3665                3670                3675                3680
Ala Gln Thr Cys Gly Thr Arg Pro Gly Leu His Arg Phe Ala Val Leu
                3685                3690                3695    
Gln Glu Asn Val Ala Trp Gly Asn Gly Arg Val Ser Val Thr Arg Val
            3700                3705                3710        
Ile Thr Val Gln Val Ala Asn Phe Thr Leu Arg Leu Glu Gln Arg Gln
        3715                3720                3725            
Trp Lys Val Thr Val Asn Gly Val Asp Met Lys Leu Pro Val Val Leu
    3730                3735                3740                
Ala Asn Gly Gln Ile Arg Ala Ser Gln His Gly Ser Asp Val Val Ile
3745                3750                3755                3760
Glu Thr Asp Phe Gly Leu Arg Val Ala Tyr Asp Leu Val Tyr Tyr Val
                3765                3770                3775    
Arg Val Thr Val Pro Gly Asn Tyr Tyr Gln Leu Met Cys Gly Leu Cys
            3780                3785                3790        
Gly Asn Tyr Asn Gly Asp Pro Lys Asp Asp Phe Gln Lys Pro Asn Gly
        3795                3800                3805            
Ser Gln Ala Gly Asn Ala Asn Glu Phe Gly Asn Ser Trp Glu Glu Val
    3810                3815                3820                
Val Pro Asp Ser Pro Cys Leu Pro Pro Pro Thr Cys Pro Pro Gly Ser
3825                3830                3835                3840
Glu Gly Cys Ile Pro Ser Glu Glu Cys Pro Pro Glu Leu Glu Lys Lys
                3845                3850                3855    
Tyr Gln Lys Glu Glu Phe Cys Gly Leu Leu Ser Ser Pro Thr Gly Pro
            3860                3865                3870        
Leu Ser Ser Cys His Lys Leu Val Asp Pro Gln Gly Pro Leu Lys Asp
        3875                3880                3885            
Cys Ile Phe Asp Leu Cys Leu Gly Gly Gly Asn Leu Ser Ile Leu Cys
    3890                3895                3900                
Ser Asn Ile His Ala Tyr Val Ser Ala Cys Gln Ala Ala Gly Gly His
3905                3910                3915                3920
Val Glu Pro Trp Arg Asn Glu Thr Phe Cys Pro Met Glu Cys Pro Gln
                3925                3930                3935    
Asn Ser His Tyr Glu Leu Cys Ala Asp Thr Cys Ser Leu Gly Cys Ser
            3940                3945                3950        
Ala Leu Ser Ala Pro Leu Gln Cys Pro Asp Gly Cys Ala Glu Gly Cys
        3955                3960                3965            
Gln Cys Asp Ser Gly Phe Leu Tyr Asn Gly Gln Ala Cys Val Pro Ile
    3970                3975                3980                
Gln Gln Cys Gly Cys Tyr His Asn Gly Val Tyr Tyr Glu Pro Glu Gln
3985                3990                3995                4000
Thr Val Leu Ile Asp Asn Cys Arg Gln Gln Cys Thr Cys His Val Gly
                4005                4010                4015    
Lys Val Val Val Cys Gln Glu His Ser Cys Lys Pro Gly Gln Val Cys
            4020                4025                4030        
Gln Pro Ser Gly Gly Ile Leu Ser Cys Val Asn Lys Asp Pro Cys His
        4035                4040                4045            
Gly Val Thr Cys Arg Pro Gln Glu Thr Cys Lys Glu Gln Gly Gly Gln
    4050                4055                4060                
Gly Val Cys Leu Pro Asn Tyr Glu Ala Thr Cys Trp Leu Trp Gly Asp
4065                4070                4075                4080
Pro His Tyr His Ser Phe Asp Gly Arg Lys Phe Asp Phe Gln Gly Thr
                4085                4090                4095    
Cys Asn Tyr Val Leu Ala Thr Thr Gly Cys Pro Gly Val Ser Thr Gln
            4100                4105                4110        
Gly Leu Thr Pro Phe Thr Val Thr Thr Lys Asn Gln Asn Arg Gly Asn
        4115                4120                4125            
Pro Ala Val Ser Tyr Val Arg Val Val Thr Val Ala Ala Leu Gly Thr
    4130                4135                4140                
Asn Ile Ser Ile His Lys Asp Glu Ile Gly Lys Val Arg Val Asn Gly
4145                4150                4155                4160
Val Leu Thr Ala Leu Pro Val Ser Val Ala Asp Gly Arg Ile Ser Val
                4165                4170                4175    
Ala Gln Gly Ala Ser Lys Ala Leu Leu Val Ala Asp Phe Gly Leu Gln
            4180                4185                4190        
Val Ser Tyr Asp Trp Asn Trp Arg Val Asp Val Thr Leu Pro Ser Ser
        4195                4200                4205            
Tyr His Gly Ala Val Cys Gly Leu Cys Gly Asn Met Asp Arg Asn Pro
    4210                4215                4220                
Asn Asn Asp Gln Val Phe Pro Asn Gly Thr Leu Ala Pro Ser Ile Pro
4225                4230                4235                4240
Ile Trp Gly Gly Ser Trp Arg Ala Pro Gly Trp Asp Pro Leu Cys Trp
                4245                4250                4255    
Asp Glu Cys Arg Gly Ser Cys Pro Thr Cys Pro Glu Asp Arg Leu Glu
            4260                4265                4270        
Gln Tyr Glu Gly Pro Gly Phe Cys Gly Pro Leu Ala Ser Gly Thr Gly
        4275                4280                4285            
Gly Pro Phe Thr Thr Cys His Ala His Val Pro Pro Glu Ser Phe Phe
    4290                4295                4300                
Lys Gly Cys Val Leu Asp Val Cys Met Gly Gly Gly Asp His Asp Ile
4305                4310                4315                4320
Leu Cys Lys Ala Leu Ala Ser Tyr Val Ala Ala Cys Gln Ala Ala Gly
                4325                4330                4335    
Val Val Ile Glu Asp Trp Arg Ala Gln Val Gly Cys Glu Ile Thr Cys
            4340                4345                4350        
Pro Glu Asn Ser His Tyr Glu Val Cys Gly Pro Pro Cys Pro Ala Ser
        4355                4360                4365            
Cys Pro Ser Pro Ala Pro Leu Thr Thr Pro Ala Val Cys Glu Gly Pro
    4370                4375                4380                
Cys Val Glu Gly Cys Gln Cys Asp Ala Gly Phe Val Leu Ser Ala Asp
4385                4390                4395                4400
Arg Cys Val Pro Leu Asn Asn Gly Cys Gly Cys Trp Ala Asn Gly Thr
                4405                4410                4415    
Tyr His Glu Ala Gly Ser Glu Phe Trp Ala Asp Gly Thr Cys Ser Gln
            4420                4425                4430        
Trp Cys Arg Cys Gly Pro Gly Gly Gly Ser Leu Val Cys Thr Pro Ala
        4435                4440                4445            
Ser Cys Gly Leu Gly Glu Val Cys Gly Leu Leu Pro Ser Gly Gln His
    4450                4455                4460                
Ser Cys Gln Pro Val Ser Thr Ala Glu Cys Gln Ala Trp Gly Asp Pro
4465                4470                4475                4480
His Tyr Val Thr Leu Asp Gly His Arg Phe Asp Phe Gln Gly Thr Cys
                4485                4490                4495    
Glu Tyr Leu Leu Ser Ala Pro Cys His Gly Pro Pro Leu Gly Ala Glu
            4500                4505                4510        
Asn Phe Thr Val Thr Val Ala Asn Glu His Arg Gly Ser Gln Ala Val
        4515                4520                4525            
Ser Tyr Thr Arg Ser Val Thr Leu Gln Ile Tyr Asn His Ser Leu Thr
    4530                4535                4540                
Leu Ser Ala Arg Trp Pro Arg Lys Leu Gln Val Asp Gly Val Phe Val
4545                4550                4555                4560
Ala Leu Pro Phe Gln Leu Asp Ser Leu Leu His Ala His Leu Ser Gly
                4565                4570                4575    
Ala Asp Val Val Val Thr Thr Thr Ser Gly Leu Ser Leu Ala Phe Asp
            4580                4585                4590        
Gly Asp Ser Phe Val Arg Leu Arg Val Pro Ala Ala Tyr Ala Ala Ser
        4595                4600                4605            
Leu Cys Gly Leu Cys Gly Asn Tyr Asn Gln Asp Pro Ala Asp Asp Leu
    4610                4615                4620                
Lys Ala Val Gly Gly Lys Pro Ala Gly Trp Gln Val Gly Gly Ala Gln
4625                4630                4635                4640
Gly Cys Gly Glu Cys Val Ser Lys Pro Cys Pro Ser Pro Cys Thr Pro
                4645                4650                4655    
Glu Gln Gln Glu Ser Phe Gly Gly Pro Asp Ala Cys Gly Val Ile Ser
            4660                4665                4670        
Ala Thr Asp Gly Pro Leu Ala Pro Cys His Gly Leu Val Pro Pro Ala
        4675                4680                4685            
Gln Tyr Phe Gln Gly Cys Leu Leu Asp Ala Cys Gln Val Gln Gly His
    4690                4695                4700                
Pro Gly Gly Leu Cys Pro Ala Val Ala Thr Tyr Val Ala Ala Cys Gln
4705                4710                4715                4720
Ala Ala Gly Ala Gln Leu Gly Glu Trp Arg Arg Pro Asp Phe Cys Pro
                4725                4730                4735    
Leu Gln Cys Pro Ala His Ser His Tyr Glu Leu Cys Gly Asp Ser Cys
            4740                4745                4750        
Pro Val Ser Cys Pro Ser Leu Ser Ala Pro Glu Gly Cys Glu Ser Ala
        4755                4760                4765            
Cys Arg Glu Gly Cys Val Cys Asp Ala Gly Phe Val Leu Ser Gly Asp
    4770                4775                4780                
Thr Cys Val Pro Val Gly Gln Cys Gly Cys Leu His Asp Gly Arg Tyr
4785                4790                4795                4800
Tyr Pro Leu Gly Glu Val Phe Tyr Pro Gly Pro Glu Cys Glu Arg Arg
                4805                4810                4815    
Cys Glu Cys Gly Pro Gly Gly His Val Thr Cys Gln Glu Gly Ala Ala
            4820                4825                4830        
Cys Gly Pro His Glu Glu Cys Arg Leu Glu Asp Gly Val Gln Ala Cys
        4835                4840                4845            
His Ala Thr Gly Cys Gly Arg Cys Leu Ala Asn Gly Gly Ile His Tyr
    4850                4855                4860                
Ile Thr Leu Asp Gly Arg Val Tyr Asp Leu His Gly Ser Cys Ser Tyr
4865                4870                4875                4880
Val Leu Ala Gln Val Cys His Pro Lys Pro Gly Asp Glu Asp Phe Ser
                4885                4890                4895    
Ile Val Leu Glu Lys Asn Ala Ala Gly His Leu Gln Arg Leu Leu Val
            4900                4905                4910        
Thr Val Ala Gly Gln Val Val Ser Leu Ala Gln Gly Gln Gln Val Thr
        4915                4920                4925            
Val Asp Gly Glu Ala Val Ala Leu Pro Val Ala Val Gly Arg Val Arg
    4930                4935                4940                
Val Thr Ala Glu Gly Arg Asn Met Val Leu Gln Thr Thr Lys Gly Leu
4945                4950                4955                4960
Arg Leu Leu Phe Asp Gly Asp Ala His Leu Leu Met Ser Ile Pro Ser
                4965                4970                4975    
Pro Phe Arg Gly Arg Leu Cys Gly Leu Cys Gly Asn Phe Asn Gly Asn
            4980                4985                4990        
Trp Ser Asp Asp Phe Val Leu Pro Asn Gly Ser Ala Ala Ser Ser Val
        4995                5000                5005            
Glu Thr Phe Gly Ala Ala Trp Arg Val Pro Gly Ser Ser Lys Gly Cys
    5010                5015                5020                
Gly Glu Gly Cys Gly Pro Gln Gly Cys Pro Val Cys Leu Ala Glu Glu
5025                5030                5035                5040
Thr Ala Pro Tyr Glu Ser Asn Glu Ala Cys Gly Gln Leu Arg Asn Pro
                5045                5050                5055    
Gln Gly Pro Phe Ala Thr Cys Gln Ala Val Leu Ser Pro Ser Glu Tyr
            5060                5065                5070        
Phe Arg Gln Cys Val Tyr Asp Leu Cys Ala Gln Lys Gly Asp Lys Ala
        5075                5080                5085            
Phe Leu Cys Arg Ser Leu Ala Ala Tyr Thr Ala Ala Cys Gln Ala Ala
    5090                5095                5100                
Gly Val Ala Val Lys Pro Trp Arg Thr Asp Ser Phe Cys Pro Leu His
5105                5110                5115                5120
Cys Pro Ala His Ser His Tyr Ser Ile Cys Thr Arg Thr Cys Gln Gly
                5125                5130                5135    
Ser Cys Ala Ala Leu Ser Gly Leu Thr Gly Cys Thr Thr Arg Cys Phe
            5140                5145                5150        
Glu Gly Cys Glu Cys Asp Asp Arg Phe Leu Leu Ser Gln Gly Val Cys
        5155                5160                5165            
Ile Pro Val Gln Asp Cys Gly Cys Thr His Asn Gly Arg Tyr Leu Pro
    5170                5175                5180                
Val Asn Ser Ser Leu Leu Thr Ser Asp Cys Ser Glu Arg Cys Ser Cys
5185                5190                5195                5200
Ser Ser Ser Ser Gly Leu Thr Cys Gln Ala Ala Gly Cys Pro Pro Gly
                5205                5210                5215    
Arg Val Cys Glu Val Lys Ala Glu Ala Arg Asn Cys Trp Ala Thr Arg
            5220                5225                5230        
Gly Leu Cys Val Leu Ser Val Gly Ala Asn Leu Thr Thr Phe Asp Gly
        5235                5240                5245            
Ala Arg Gly Ala Thr Thr Ser Pro Gly Val Tyr Glu Leu Ser Ser Arg
    5250                5255                5260                
Cys Pro Gly Leu Gln Asn Thr Ile Pro Trp Tyr Arg Val Val Ala Glu
5265                5270                5275                5280
Val Gln Ile Cys His Gly Lys Thr Glu Ala Val Gly Gln Val His Ile
                5285                5290                5295    
Phe Phe Gln Asp Gly Met Val Thr Leu Thr Pro Asn Lys Gly Val Trp
            5300                5305                5310        
Val Asn Gly Leu Arg Val Asp Leu Pro Ala Glu Lys Leu Ala Ser Val
        5315                5320                5325            
Ser Val Ser Arg Thr Pro Asp Gly Ser Leu Leu Val Arg Gln Lys Ala
    5330                5335                5340                
Gly Val Gln Val Trp Leu Gly Ala Asn Gly Lys Val Ala Val Ile Val
5345                5350                5355                5360
Ser Asn Asp His Ala Gly Lys Leu Cys Gly Ala Cys Gly Asn Phe Asp
                5365                5370                5375    
Gly Asp Gln Thr Asn Asp Trp His Asp Ser Gln Glu Lys Pro Ala Met
            5380                5385                5390        
Glu Lys Trp Arg Ala Gln Asp Phe Ser Pro Cys Tyr Gly
        5395                5400                5405


<210> 5565
<211> 1202
<212> PRT
<213> Homo sapiens

<400> 5565
Val Asp Val Thr Leu Pro Ser Ser Tyr His Gly Ala Val Cys Gly Leu
 1               5                  10                  15      
Cys Gly Asn Met Asp Arg Asn Pro Asn Asn Asp Gln Val Phe Pro Asn
            20                  25                  30          
Gly Thr Leu Ala Pro Ser Ile Pro Ile Trp Gly Gly Ser Trp Arg Ala
        35                  40                  45              
Pro Gly Trp Asp Pro Leu Cys Trp Asp Glu Cys Arg Gly Ser Cys Pro
    50                  55                  60                  
Thr Cys Pro Glu Asp Arg Leu Glu Gln Tyr Glu Gly Pro Gly Phe Cys
65                  70                  75                  80  
Gly Pro Leu Ala Pro Gly Thr Gly Gly Pro Phe Thr Thr Cys His Ala
                85                  90                  95      
His Val Pro Pro Glu Ser Phe Phe Lys Gly Cys Val Leu Asp Val Cys
            100                 105                 110         
Met Gly Gly Gly Asp Arg Asp Ile Leu Cys Lys Ala Leu Ala Ser Tyr
        115                 120                 125             
Val Ala Ala Cys Gln Ala Ala Gly Val Val Ile Glu Asp Trp Arg Ala
    130                 135                 140                 
Gln Val Gly Cys Glu Ile Thr Cys Pro Glu Asn Ser His Tyr Glu Val
145                 150                 155                 160 
Cys Gly Pro Pro Cys Pro Ala Ser Cys Pro Ser Pro Ala Pro Leu Thr
                165                 170                 175     
Thr Pro Ala Val Cys Glu Gly Pro Cys Val Glu Gly Cys Gln Cys Asp
            180                 185                 190         
Ala Gly Phe Val Leu Ser Ala Asp Arg Cys Val Pro Leu Asn Asn Gly
        195                 200                 205             
Cys Gly Cys Trp Ala Asn Gly Thr Tyr His Glu Ala Gly Ser Glu Phe
    210                 215                 220                 
Trp Ala Asp Gly Thr Cys Ser Gln Trp Cys Arg Cys Gly Pro Gly Gly
225                 230                 235                 240 
Gly Ser Leu Val Cys Thr Pro Ala Ser Cys Gly Leu Gly Glu Val Cys
                245                 250                 255     
Gly Leu Leu Pro Ser Gly Gln His Gly Cys Gln Pro Val Ser Thr Ala
            260                 265                 270         
Glu Cys Gln Ala Trp Gly Asp Pro His Tyr Val Thr Leu Asp Gly His
        275                 280                 285             
Arg Phe Asp Phe Gln Gly Thr Cys Glu Tyr Leu Leu Ser Ala Pro Cys
    290                 295                 300                 
His Gly Pro Pro Leu Gly Ala Glu Asn Phe Thr Val Thr Val Ala Asn
305                 310                 315                 320 
Glu His Arg Gly Ser Gln Ala Val Ser Tyr Thr Arg Ser Val Thr Leu
                325                 330                 335     
Gln Ile Tyr Asn His Ser Leu Thr Leu Ser Ala Arg Trp Pro Arg Lys
            340                 345                 350         
Leu Gln Val Asp Gly Val Phe Val Ala Leu Pro Phe Gln Leu Asp Ser
        355                 360                 365             
Leu Leu His Ala His Leu Ser Gly Ala Asp Val Val Val Thr Thr Thr
    370                 375                 380                 
Ser Gly Leu Ser Leu Ala Phe Asp Gly Asp Ser Phe Val Arg Leu Arg
385                 390                 395                 400 
Val Pro Ala Ala Tyr Ala Ala Ser Leu Cys Gly Leu Cys Gly Asn Tyr
                405                 410                 415     
Asn Gln Asp Pro Ala Asp Asp Leu Lys Ala Val Gly Gly Lys Pro Ala
            420                 425                 430         
Gly Trp Gln Val Gly Gly Ala Gln Gly Cys Gly Glu Cys Val Ser Lys
        435                 440                 445             
Pro Cys Pro Ser Pro Cys Thr Pro Glu Gln Gln Glu Ser Phe Gly Gly
    450                 455                 460                 
Pro Asp Ala Cys Gly Val Ile Ser Ala Thr Asp Gly Pro Leu Ala Pro
465                 470                 475                 480 
Cys His Gly Leu Val Pro Pro Ala Gln Tyr Phe Gln Gly Cys Leu Leu
                485                 490                 495     
Asp Ala Cys Gln Val Gln Gly His Pro Gly Gly Leu Cys Pro Ala Val
            500                 505                 510         
Ala Thr Tyr Val Ala Ala Cys Gln Ala Ala Gly Ala Gln Leu Gly Glu
        515                 520                 525             
Trp Arg Arg Pro Asp Phe Cys Pro Leu Gln Cys Pro Ala His Ser His
    530                 535                 540                 
Tyr Glu Leu Cys Gly Asp Ser Cys Pro Val Ser Cys Pro Ser Leu Ser
545                 550                 555                 560 
Ala Pro Glu Gly Cys Glu Ser Ala Cys Arg Glu Gly Cys Val Cys Asp
                565                 570                 575     
Ala Gly Phe Val Leu Ser Gly Asp Thr Cys Val Pro Val Gly Gln Cys
            580                 585                 590         
Gly Cys Leu His Asp Gly Arg Tyr Tyr Pro Leu Gly Glu Val Phe Tyr
        595                 600                 605             
Pro Gly Pro Glu Cys Glu Arg Arg Cys Glu Cys Gly Pro Gly Gly His
    610                 615                 620                 
Val Thr Cys Gln Glu Gly Ala Ala Cys Gly Pro His Glu Glu Cys Arg
625                 630                 635                 640 
Leu Glu Asp Gly Val Gln Ala Cys His Ala Thr Gly Cys Gly Arg Cys
                645                 650                 655     
Leu Ala Asn Gly Gly Ile His Tyr Ile Thr Leu Asp Gly Arg Val Tyr
            660                 665                 670         
Asp Leu His Gly Ser Cys Ser Tyr Val Leu Ala Gln Val Cys His Pro
        675                 680                 685             
Lys Pro Gly Asp Glu Asp Phe Ser Ile Val Leu Glu Lys Asn Ala Ala
    690                 695                 700                 
Gly Asp Leu Gln Arg Leu Leu Val Thr Val Ala Gly Gln Val Val Ser
705                 710                 715                 720 
Leu Ala Gln Gly Gln Gln Val Thr Val Asp Gly Glu Ala Val Ala Leu
                725                 730                 735     
Pro Val Ala Val Gly Arg Val Arg Val Thr Ala Glu Gly Arg Asn Met
            740                 745                 750         
Val Leu Gln Thr Thr Lys Gly Leu Arg Leu Leu Phe Asp Gly Asp Ala
        755                 760                 765             
His Leu Leu Met Ser Ile Pro Ser Pro Phe Arg Gly Arg Leu Cys Gly
    770                 775                 780                 
Leu Cys Gly Asn Phe Asn Gly Asn Trp Ser Asp Asp Phe Val Leu Pro
785                 790                 795                 800 
Asn Gly Ser Ala Ala Ser Ser Val Glu Thr Phe Gly Ala Ala Trp Arg
                805                 810                 815     
Ala Pro Gly Ser Ser Lys Gly Cys Gly Glu Gly Cys Gly Pro Gln Gly
            820                 825                 830         
Cys Pro Val Cys Leu Ala Glu Glu Thr Ala Pro Tyr Glu Ser Asn Glu
        835                 840                 845             
Ala Cys Gly Gln Leu Arg Asn Pro Gln Gly Pro Phe Ala Thr Cys Gln
    850                 855                 860                 
Ala Val Leu Ser Pro Ser Glu Tyr Phe Arg Gln Cys Val Tyr Asp Leu
865                 870                 875                 880 
Cys Ala Gln Lys Gly Asp Lys Ala Phe Leu Cys Arg Ser Leu Ala Ala
                885                 890                 895     
Tyr Thr Ala Ala Cys Gln Ala Ala Gly Val Ala Val Lys Pro Trp Arg
            900                 905                 910         
Thr Asp Ser Phe Cys Pro Leu His Cys Pro Ala His Ser His Tyr Ser
        915                 920                 925             
Ile Cys Thr Arg Thr Cys Gln Gly Ser Cys Ala Ala Leu Ser Gly Leu
    930                 935                 940                 
Thr Gly Cys Thr Thr Arg Cys Phe Glu Gly Cys Glu Cys Asp Asp Arg
945                 950                 955                 960 
Phe Leu Leu Ser Gln Gly Val Cys Ile Pro Val Gln Asp Cys Gly Cys
                965                 970                 975     
Thr His Asn Gly Arg Tyr Leu Pro Val Asn Ser Ser Leu Leu Thr Ser
            980                 985                 990         
Asp Cys Ser Glu Arg Cys Ser Cys Ser Ser Ser Ser Gly Leu Thr Cys
        995                 1000                1005            
Gln Ala Ala Gly Cys Pro Pro Gly Arg Val Cys Glu Val Lys Ala Glu
    1010                1015                1020                
Ala Arg Asn Cys Trp Ala Thr Arg Gly Leu Cys Val Leu Ser Val Gly
1025                1030                1035                1040
Ala Asn Leu Thr Thr Phe Asp Gly Ala Arg Gly Ala Thr Thr Ser Pro
                1045                1050                1055    
Gly Val Tyr Glu Leu Ser Ser Arg Cys Pro Gly Leu Gln Asn Thr Ile
            1060                1065                1070        
Pro Trp Tyr Arg Val Val Ala Glu Val Gln Ile Cys His Gly Lys Thr
        1075                1080                1085            
Glu Ala Val Gly Gln Val His Ile Phe Phe Gln Asp Gly Met Val Thr
    1090                1095                1100                
Leu Thr Pro Asn Lys Gly Val Trp Val Asn Gly Leu Arg Val Asp Leu
1105                1110                1115                1120
Pro Ala Glu Lys Leu Ala Ser Val Ser Val Ser Arg Thr Pro Asp Gly
                1125                1130                1135    
Ser Leu Leu Val Arg Gln Lys Ala Gly Val Gln Val Trp Leu Gly Ala
            1140                1145                1150        
Asn Gly Lys Val Ala Val Ile Val Ser Asn Asp His Ala Gly Lys Leu
        1155                1160                1165            
Cys Gly Ala Cys Gly Asn Phe Asp Gly Asp Gln Thr Asn Asp Trp His
    1170                1175                1180                
Asp Ser Gln Glu Lys Pro Ala Met Glu Lys Trp Arg Ala Gln Asp Phe
1185                1190                1195                1200
Ser Pro
        


<210> 5566
<211> 493
<212> PRT
<213> Homo sapiens

<400> 5566
Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His
 1               5                  10                  15      
Ala Cys Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile
            20                  25                  30          
Thr Lys Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile
        35                  40                  45              
Gln Thr Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys
    50                  55                  60                  
Ala Met Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln
65                  70                  75                  80  
Ile Ser His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala
                85                  90                  95      
Lys Ser Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly
            100                 105                 110         
Thr Leu Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln
        115                 120                 125             
Ser Ile Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr
    130                 135                 140                 
Gln Leu Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys
145                 150                 155                 160 
Tyr Leu Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu
                165                 170                 175     
Pro Gly Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu
            180                 185                 190         
Lys Leu Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser
        195                 200                 205             
Asn Ile Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser
    210                 215                 220                 
Asp Gly Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile
225                 230                 235                 240 
Thr Ala Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys
                245                 250                 255     
Asn Val Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu
            260                 265                 270         
Gly Asp Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His
        275                 280                 285             
Ser Leu Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu
    290                 295                 300                 
Met Gly Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr
305                 310                 315                 320 
Asn Gln Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala
                325                 330                 335     
Gln Val Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn
            340                 345                 350         
Lys Gly Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro
        355                 360                 365             
Arg Pro Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile
    370                 375                 380                 
Val Thr Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser
385                 390                 395                 400 
Leu Leu Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu
                405                 410                 415     
Ser Ser Ser Glu Ser Ile Gln Ser Phe Leu Gln Ser Met Ile Thr Ala
            420                 425                 430         
Val Gly Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala
        435                 440                 445             
Leu Met Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu
    450                 455                 460                 
Ile Ile Thr Arg Asp Gly Phe Leu Leu Leu Gln Met Asp Phe Gly Phe
465                 470                 475                 480 
Pro Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu Ser
                485                 490             


<210> 5567
<211> 967
<212> PRT
<213> Homo sapiens

<400> 5567
Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile
 1               5                  10                  15      
Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val
            20                  25                  30          
Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser
        35                  40                  45              
Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr
    50                  55                  60                  
Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu
65                  70                  75                  80  
Lys Pro Asp Ser Tyr Gln Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn
                85                  90                  95      
Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr
            100                 105                 110         
Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn
        115                 120                 125             
Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly
    130                 135                 140                 
Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu
145                 150                 155                 160 
Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr
                165                 170                 175     
Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly
            180                 185                 190         
Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala
        195                 200                 205             
Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe
    210                 215                 220                 
Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro
225                 230                 235                 240 
Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr
                245                 250                 255     
Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr
            260                 265                 270         
Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp
        275                 280                 285             
Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala
    290                 295                 300                 
Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val
305                 310                 315                 320 
Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr
                325                 330                 335     
Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly
            340                 345                 350         
Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu
        355                 360                 365             
Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr
    370                 375                 380                 
Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr
385                 390                 395                 400 
Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr
                405                 410                 415     
Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys
            420                 425                 430         
Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala
        435                 440                 445             
Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr
    450                 455                 460                 
Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly
465                 470                 475                 480 
Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe
                485                 490                 495     
Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr
            500                 505                 510         
Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg
        515                 520                 525             
Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr
    530                 535                 540                 
Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr
545                 550                 555                 560 
Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg
                565                 570                 575     
Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg
            580                 585                 590         
Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln
        595                 600                 605             
Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu
    610                 615                 620                 
Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg
625                 630                 635                 640 
Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile
                645                 650                 655     
Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His
            660                 665                 670         
Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu
        675                 680                 685             
Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr
    690                 695                 700                 
Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn
705                 710                 715                 720 
Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn
                725                 730                 735     
Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser
            740                 745                 750         
Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys
        755                 760                 765             
Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn
    770                 775                 780                 
Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala
785                 790                 795                 800 
Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe
                805                 810                 815     
Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu
            820                 825                 830         
Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr
        835                 840                 845             
Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile
    850                 855                 860                 
Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val
865                 870                 875                 880 
Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe
                885                 890                 895     
Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu
            900                 905                 910         
Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr
        915                 920                 925             
Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr
    930                 935                 940                 
Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln
945                 950                 955                 960 
Trp Phe Thr Glu Asn Ser Lys
                965         


<210> 5568
<211> 198
<212> PRT
<213> Homo sapiens

<400> 5568
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro
            20                  25                  30          
Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln
        35                  40                  45              
Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu
    50                  55                  60                  
Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu
65                  70                  75                  80  
Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys
                85                  90                  95      
Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe
            100                 105                 110         
Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val
        115                 120                 125             
Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys
    130                 135                 140                 
Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg
145                 150                 155                 160 
Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser
                165                 170                 175     
Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile
            180                 185                 190         
Asp Gln Cys Ile Asp Gly
        195             


<210> 5569
<211> 567
<212> PRT
<213> Homo sapiens

<400> 5569
Met Thr Ser Arg Cys Ser Gly Ala Gln Ser Tyr Leu Leu His Ala Val
 1               5                  10                  15      
Val Pro Gly Pro Trp Gln Glu Asp Val Ala Asp Ala Glu Glu Cys Ala
            20                  25                  30          
Gly Arg Cys Gly Leu Leu Met Asp Cys Trp Ala Phe His Tyr Asn Val
        35                  40                  45              
Ser Ser His Gly Cys Gln Leu Leu Pro Trp Thr Gln His Ser Pro His
    50                  55                  60                  
Ser Arg Leu Arg His Ser Gly Arg Cys Asp Leu Phe Gln Lys Lys Asp
65                  70                  75                  80  
Tyr Ile Arg Thr Cys Ile Met Asn Asn Gly Val Gly Tyr Arg Asp Thr
                85                  90                  95      
Met Ala Thr Thr Val Gly Gly Leu Ser Cys Gln Ala Trp Ser His Lys
            100                 105                 110         
Phe Pro Asn Asp His Gln Tyr Met Pro Thr Leu Arg Asn Gly Leu Glu
        115                 120                 125             
Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Pro Gly Gly Pro Trp Cys
    130                 135                 140                 
His Thr Thr Asp Pro Ala Val Arg Phe Gln Ser Cys Gly Ile Lys Ser
145                 150                 155                 160 
Cys Leu Val Ala Ala Cys Val Trp Cys Asn Gly Glu Glu Tyr Arg Gly
                165                 170                 175     
Ala Val Asp Arg Thr Glu Ser Gly Arg Glu Cys Gln Arg Trp Asp Leu
            180                 185                 190         
Gln His Pro His Gln His Pro Phe Glu Pro Gly Lys Phe Leu Asp Gln
        195                 200                 205             
Gly Leu Asp Asp Asn Tyr Cys Arg Ser Pro Asp Gly Ser Gln Arg Pro
    210                 215                 220                 
Trp Cys Tyr Thr Thr Asp Pro Gln Ile Glu Arg Glu Phe Cys Asp Leu
225                 230                 235                 240 
Pro Arg Cys Gly Ser Glu Ala Gln Pro Arg Gln Glu Ala Thr Ser Val
                245                 250                 255     
Ser Cys Phe Arg Gly Lys Gly Glu Gly Tyr Arg Gly Thr Ala Asn Thr
            260                 265                 270         
Thr Thr Ala Gly Val Pro Cys Gln Arg Trp Asp Ala Gln Ile Pro His
        275                 280                 285             
Gln His Arg Phe Thr Pro Glu Lys Tyr Ala Cys Lys Asp Leu Arg Glu
    290                 295                 300                 
Asn Phe Cys Arg Asn Pro Asp Gly Ser Glu Ala Pro Trp Cys Phe Thr
305                 310                 315                 320 
Leu Arg Pro Gly Thr Arg Val Gly Phe Cys Tyr Gln Ile Arg Arg Cys
                325                 330                 335     
Thr Asp Asp Val Arg Pro Gln Asp Cys Tyr His Gly Ala Gly Glu Gln
            340                 345                 350         
Tyr Arg Gly Thr Val Ser Lys Thr Arg Lys Gly Val Gln Cys Gln Arg
        355                 360                 365             
Trp Ser Ala Glu Thr Pro His Lys Pro Gln Phe Thr Phe Thr Ser Glu
    370                 375                 380                 
Pro His Ala Gln Leu Glu Glu Asn Phe Cys Gln Asn Pro Asp Gly Asp
385                 390                 395                 400 
Ser His Gly Pro Trp Cys Tyr Thr Met Asp Pro Arg Thr Pro Phe Asp
                405                 410                 415     
Tyr Cys Ala Leu Arg Arg Cys Ala Asp Asp Gln Pro Pro Ser Ile Leu
            420                 425                 430         
Asp Pro Pro Asp Gln Val Gln Phe Glu Lys Cys Gly Lys Arg Val Asp
        435                 440                 445             
Arg Leu Asp Gln Arg Arg Ser Lys Leu Arg Val Ala Gly Gly His Pro
    450                 455                 460                 
Gly Asn Ser Pro Trp Thr Val Ser Leu Gly Asn Arg Gln Gly Gln His
465                 470                 475                 480 
Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp Ile Leu Thr Ala Arg
                485                 490                 495     
Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr Gly Tyr Glu Val Trp
            500                 505                 510         
Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly Glu Pro Gly Leu Gln
        515                 520                 525             
Arg Val Pro Val Ala Lys Met Leu Cys Gly Pro Ser Gly Ser Gln Leu
    530                 535                 540                 
Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu Asn Gln Arg Val Ala
545                 550                 555                 560 
Leu Ile Cys Leu Pro Pro Glu
                565         


<210> 5570
<211> 207
<212> PRT
<213> Homo sapiens

<400> 5570
Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln
            20                  25                  30          
Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly
        35                  40                  45              
Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys
    50                  55                  60                  
Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp
65                  70                  75                  80  
Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe
                85                  90                  95      
His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu
            100                 105                 110         
Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp
        115                 120                 125             
Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr
    130                 135                 140                 
Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys
145                 150                 155                 160 
Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln
                165                 170                 175     
Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg
            180                 185                 190         
Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala
        195                 200                 205         


<210> 5571
<211> 1482
<212> PRT
<213> Homo sapiens

<400> 5571
Met Arg Lys Asp Arg Leu Leu His Leu Cys Leu Val Leu Leu Leu Ile
 1               5                  10                  15      
Leu Leu Ser Ala Ser Asp Ser Asn Ser Thr Glu Pro Gln Tyr Met Val
            20                  25                  30          
Leu Val Pro Ser Leu Leu His Thr Glu Ala Pro Lys Lys Gly Cys Val
        35                  40                  45              
Leu Leu Ser His Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu Glu
    50                  55                  60                  
Ser Gly Arg Glu Asn Arg Ser Leu Phe Thr Asp Leu Val Ala Glu Lys
65                  70                  75                  80  
Asp Leu Phe His Cys Val Ser Phe Thr Leu Pro Arg Ile Ser Ala Ser
                85                  90                  95      
Ser Glu Val Ala Phe Leu Ser Ile Gln Ile Lys Gly Pro Thr Gln Asp
            100                 105                 110         
Phe Arg Lys Arg Asn Thr Val Leu Val Leu Asn Thr Gln Ser Leu Val
        115                 120                 125             
Phe Val Gln Thr Asp Lys Pro Met Tyr Lys Pro Gly Gln Thr Val Arg
    130                 135                 140                 
Phe Arg Val Val Ser Val Asp Glu Asn Phe Arg Pro Arg Asn Glu Leu
145                 150                 155                 160 
Ile Pro Leu Ile Tyr Leu Glu Asn Pro Arg Arg Asn Arg Ile Ala Gln
                165                 170                 175     
Trp Gln Ser Leu Lys Leu Glu Ala Gly Ile Asn Gln Leu Ser Phe Pro
            180                 185                 190         
Leu Ser Ser Glu Pro Ile Gln Gly Ser Tyr Arg Val Val Val Gln Thr
        195                 200                 205             
Glu Ser Gly Gly Arg Ile Gln His Pro Phe Thr Val Glu Glu Phe Val
    210                 215                 220                 
Leu Pro Lys Phe Glu Val Lys Val Gln Val Pro Lys Ile Ile Ser Ile
225                 230                 235                 240 
Met Asp Glu Lys Val Asn Ile Thr Val Cys Gly Glu Tyr Thr Tyr Gly
                245                 250                 255     
Lys Pro Val Pro Gly Leu Ala Thr Val Ser Leu Cys Arg Lys Leu Ser
            260                 265                 270         
Arg Val Leu Asn Cys Asp Lys Gln Glu Val Cys Glu Glu Phe Ser Gln
        275                 280                 285             
Gln Leu Asn Ser Asn Gly Cys Ile Thr Gln Gln Val His Thr Lys Met
    290                 295                 300                 
Leu Gln Ile Thr Asn Thr Gly Phe Glu Met Lys Leu Arg Val Glu Ala
305                 310                 315                 320 
Arg Ile Arg Glu Glu Gly Thr Asp Leu Glu Val Thr Ala Asn Arg Ile
                325                 330                 335     
Ser Glu Ile Thr Asn Ile Val Ser Lys Leu Lys Phe Val Lys Val Asp
            340                 345                 350         
Ser His Phe Arg Gln Gly Ile Pro Phe Phe Ala Gln Val Leu Leu Val
        355                 360                 365             
Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Leu Phe Phe Ile Ser Val
    370                 375                 380                 
Asn Asp Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asn Glu Gln Gly Leu
385                 390                 395                 400 
Ala Gln Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu Phe
                405                 410                 415     
Val Arg Val Phe Thr Val His Pro Asn Leu Cys Phe His Tyr Ser Trp
            420                 425                 430         
Val Ala Glu Asp His Gln Gly Ala Gln His Thr Ala Asn Arg Val Phe
        435                 440                 445             
Ser Leu Ser Gly Ser Tyr Ile His Leu Glu Pro Val Ala Gly Thr Leu
    450                 455                 460                 
Pro Cys Gly His Thr Glu Thr Ile Thr Ala His Tyr Thr Leu Asn Arg
465                 470                 475                 480 
Gln Ala Met Gly Glu Leu Ser Glu Leu Ser Phe His Tyr Leu Ile Met
                485                 490                 495     
Ala Lys Gly Val Ile Val Arg Ser Gly Thr His Thr Leu Pro Val Glu
            500                 505                 510         
Ser Gly Asp Met Lys Gly Ser Phe Ala Leu Ser Phe Pro Val Glu Ser
        515                 520                 525             
Asp Val Ala Pro Ile Ala Arg Met Phe Ile Phe Ala Ile Leu Pro Asp
    530                 535                 540                 
Gly Glu Val Val Gly Asp Ser Glu Lys Phe Glu Ile Glu Asn Cys Leu
545                 550                 555                 560 
Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ala Gln Ser Pro Pro Ala
                565                 570                 575     
Ser His Ala His Leu Gln Val Ala Ala Ala Pro Gln Ser Leu Cys Ala
            580                 585                 590         
Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys Pro Glu Ala Glu
        595                 600                 605             
Leu Ser Val Ser Ser Val Tyr Asn Leu Leu Thr Val Lys Asp Leu Thr
    610                 615                 620                 
Asn Phe Pro Asp Asn Val Asp Gln Gln Glu Glu Glu Gln Gly His Cys
625                 630                 635                 640 
Pro Arg Pro Phe Phe Ile His Asn Gly Ala Ile Tyr Val Pro Leu Ser
                645                 650                 655     
Ser Asn Glu Ala Asp Ile Tyr Ser Phe Leu Lys Gly Met Gly Leu Lys
            660                 665                 670         
Val Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Ser Cys Ser Val Ile
        675                 680                 685             
Pro Ser Val Ser Ala Gly Ala Val Gly Gln Gly Tyr Tyr Gly Ala Gly
    690                 695                 700                 
Leu Gly Val Val Glu Arg Pro Tyr Val Pro Gln Leu Gly Thr Tyr Asn
705                 710                 715                 720 
Val Ile Pro Leu Asn Asn Glu Gln Ser Ser Gly Pro Val Pro Glu Thr
                725                 730                 735     
Val Arg Ser Tyr Phe Pro Glu Thr Trp Ile Trp Glu Leu Val Ala Val
            740                 745                 750         
Asn Ser Ser Gly Val Ala Glu Val Gly Val Thr Val Pro Asp Thr Ile
        755                 760                 765             
Thr Glu Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu
    770                 775                 780                 
Gly Ile Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln Pro Phe Phe Val
785                 790                 795                 800 
Glu Leu Thr Met Pro Tyr Ser Val Ile Arg Gly Glu Val Phe Thr Leu
                805                 810                 815     
Lys Ala Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile Arg Val Ser Val
            820                 825                 830         
Gln Leu Lys Ala Ser Pro Ala Phe Leu Ala Ser Gln Asn Thr Lys Gly
        835                 840                 845             
Glu Glu Ser Tyr Cys Ile Cys Gly Ser Glu Arg Gln Thr Leu Ser Trp
    850                 855                 860                 
Thr Val Thr Pro Lys Thr Leu Gly Asn Val Asn Phe Ser Val Ser Ala
865                 870                 875                 880 
Glu Ala Met Gln Ser Leu Glu Leu Cys Gly Asn Glu Val Val Glu Val
                885                 890                 895     
Pro Glu Ile Lys Arg Lys Asp Thr Val Ile Lys Thr Leu Leu Val Glu
            900                 905                 910         
Ala Glu Gly Ile Glu Gln Glu Lys Thr Phe Ser Ser Met Thr Cys Ala
        915                 920                 925             
Ser Gly Ala Asn Val Ser Glu Gln Leu Ser Leu Lys Leu Pro Ser Asn
    930                 935                 940                 
Val Val Lys Glu Ser Ala Arg Ala Ser Phe Ser Val Leu Gly Asp Ile
945                 950                 955                 960 
Leu Gly Ser Ala Met Gln Asn Ile Gln Asn Leu Leu Gln Met Pro Tyr
                965                 970                 975     
Gly Cys Gly Glu Gln Asn Met Val Leu Phe Ala Pro Asn Ile Tyr Val
            980                 985                 990         
Leu Asn Tyr Leu Asn Glu Thr Gln Gln Leu Thr Gln Glu Ile Lys Ala
        995                 1000                1005            
Lys Ala Val Gly Tyr Leu Ile Thr Gly Tyr Gln Arg Gln Leu Asn Tyr
    1010                1015                1020                
Lys His Gln Asp Gly Ser Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg
1025                1030                1035                1040
Asn Gln Gly Asn Thr Trp Leu Thr Ala Phe Val Leu Lys Thr Phe Ala
                1045                1050                1055    
Gln Ala Arg Ser Tyr Ile Phe Ile Asp Glu Ala His Ile Thr Gln Ser
            1060                1065                1070        
Leu Thr Trp Leu Ser Gln Met Gln Lys Asp Asn Gly Cys Phe Arg Ser
        1075                1080                1085            
Ser Gly Ser Leu Leu Asn Asn Ala Ile Lys Gly Gly Val Glu Asp Glu
    1090                1095                1100                
Ala Thr Leu Ser Ala Tyr Val Thr Ile Ala Leu Leu Glu Ile Pro Leu
1105                1110                1115                1120
Pro Val Thr Asn Pro Ile Val Arg Asn Ala Leu Phe Cys Leu Glu Ser
                1125                1130                1135    
Ala Trp Asn Val Ala Lys Glu Gly Thr His Gly Ser His Val Tyr Thr
            1140                1145                1150        
Lys Ala Leu Leu Ala Tyr Ala Phe Ser Leu Leu Gly Lys Gln Asn Gln
        1155                1160                1165            
Asn Arg Glu Ile Leu Asn Ser Leu Asp Lys Glu Ala Val Lys Glu Asp
    1170                1175                1180                
Asn Leu Val His Trp Glu Arg Pro Gln Arg Pro Lys Ala Pro Val Gly
1185                1190                1195                1200
His Leu Tyr Gln Thr Gln Ala Pro Ser Ala Glu Val Glu Met Thr Ser
                1205                1210                1215    
Tyr Val Leu Leu Ala Tyr Leu Thr Ala Gln Pro Ala Pro Thr Ser Gly
            1220                1225                1230        
Asp Leu Thr Ser Ala Thr Asn Ile Val Lys Trp Ile Met Lys Gln Gln
        1235                1240                1245            
Asn Ala Gln Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu
    1250                1255                1260                
His Ala Leu Ser Arg Tyr Gly Ala Ala Thr Phe Thr Arg Thr Glu Lys
1265                1270                1275                1280
Thr Ala Gln Val Thr Val Gln Asp Ser Gln Thr Phe Ser Thr Asn Phe
                1285                1290                1295    
Gln Val Asp Asn Asn Asn Leu Leu Leu Leu Gln Gln Ile Ser Leu Pro
            1300                1305                1310        
Glu Leu Pro Gly Glu Tyr Val Ile Thr Val Thr Gly Glu Arg Cys Val
        1315                1320                1325            
Tyr Leu Gln Thr Ser Met Lys Tyr Asn Ile Leu Pro Glu Lys Glu Asp
    1330                1335                1340                
Ser Pro Phe Ala Leu Lys Val Gln Thr Val Pro Gln Thr Cys Asp Gly
1345                1350                1355                1360
His Lys Ala His Thr Ser Phe Gln Ile Ser Leu Thr Ile Ser Tyr Thr
                1365                1370                1375    
Gly Asn Arg Pro Ala Ser Asn Met Val Ile Val Asp Val Lys Met Val
            1380                1385                1390        
Ser Gly Phe Ile Pro Leu Lys Pro Thr Val Lys Met Leu Glu Arg Ser
        1395                1400                1405            
Ser Ser Val Ser Arg Thr Glu Val Ser Asn Asn His Val Leu Ile Tyr
    1410                1415                1420                
Val Glu Gln Val Thr Asn Gln Thr Leu Ser Phe Ser Phe Met Val Leu
1425                1430                1435                1440
Gln Asp Ile Pro Val Gly Asp Leu Lys Pro Ala Ile Val Lys Val Tyr
                1445                1450                1455    
Asp Tyr Tyr Glu Thr Asp Glu Ser Val Val Ala Glu Tyr Ile Ala Pro
            1460                1465                1470        
Cys Ser Thr Asp Thr Glu His Gly Asn Val
        1475                1480        


<210> 5572
<211> 1182
<212> PRT
<213> Homo sapiens

<400> 5572
Met Gly Gln Gln Val Gly Arg Val Gly Glu Ala Pro Gly Leu Gln Gln
 1               5                  10                  15      
Pro Gln Pro Arg Gly Ile Arg Gly Ser Ser Ala Ala Arg Pro Ser Gly
            20                  25                  30          
Arg Arg Arg Asp Pro Ala Gly Arg Thr Thr Glu Thr Gly Phe Asn Ile
        35                  40                  45              
Phe Thr Gln His Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe Glu
    50                  55                  60                  
Gly Asp Lys Thr Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro Tyr
65                  70                  75                  80  
Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser
                85                  90                  95      
Ser Lys Glu Asn Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe
            100                 105                 110         
Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile
        115                 120                 125             
Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu
    130                 135                 140                 
Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn
145                 150                 155                 160 
Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly
                165                 170                 175     
Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn
            180                 185                 190         
Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser
        195                 200                 205             
Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr
    210                 215                 220                 
Thr Ala Asp Gly Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr
225                 230                 235                 240 
Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly Leu Val
                245                 250                 255     
Thr Thr Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr
            260                 265                 270         
Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile
        275                 280                 285             
Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val
    290                 295                 300                 
Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys
305                 310                 315                 320 
Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met
                325                 330                 335     
Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr
            340                 345                 350         
Leu Glu Pro Pro Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn
        355                 360                 365             
Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val
    370                 375                 380                 
Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu
385                 390                 395                 400 
Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu
                405                 410                 415     
Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg
            420                 425                 430         
Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro
        435                 440                 445             
Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile
    450                 455                 460                 
Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr
465                 470                 475                 480 
Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp
                485                 490                 495     
Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro
            500                 505                 510         
Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp
        515                 520                 525             
Arg Pro Ser Phe Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His
    530                 535                 540                 
Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala
545                 550                 555                 560 
Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro
                565                 570                 575     
Ser Lys Thr Arg Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile
            580                 585                 590         
Glu Gly Ala Gln Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro
        595                 600                 605             
Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro
    610                 615                 620                 
Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys
625                 630                 635                 640 
Glu Thr Cys Phe Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe
                645                 650                 655     
Met Lys Lys Arg Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe
            660                 665                 670         
Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn
        675                 680                 685             
Phe Ser Ser Val Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr
    690                 695                 700                 
Pro Ala Gln Gln Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly
705                 710                 715                 720 
Ser Phe Ala Gln Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly
                725                 730                 735     
Gly Ser Gly Thr Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe
            740                 745                 750         
Thr Pro Arg Leu Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro
        755                 760                 765             
Thr Ala Ser Asp Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr
    770                 775                 780                 
Ser Ser Met Ser Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr
785                 790                 795                 800 
Leu Pro Arg Asn Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val
                805                 810                 815     
Ser Thr Ser Ser Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met
            820                 825                 830         
Leu Pro Lys Lys Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro
        835                 840                 845             
Lys Ala Lys Leu Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr
    850                 855                 860                 
Pro Ser Gly Asp Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly
865                 870                 875                 880 
Val Ala Gly Val Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly
                885                 890                 895     
Ala Arg Leu Gly Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly
            900                 905                 910         
Trp Pro Ser Pro Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn
        915                 920                 925             
His Lys Val Pro Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala
    930                 935                 940                 
Asp Val Gln Leu Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu
945                 950                 955                 960 
Leu Ser Glu His Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg
                965                 970                 975     
Arg Val Lys Pro Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu
            980                 985                 990         
Leu Gln His Pro Ser Ile Cys Ser Asp Pro Thr Glu Glu Pro Thr Ala
        995                 1000                1005            
Leu Thr Ala Gly Gln Ser Thr Ser Glu Thr Gln Glu Gly Gly Lys Lys
    1010                1015                1020                
Ala Ala Leu Gly Ala Val Pro Ile Ser Gly Lys Ala Gly Arg Pro Val
1025                1030                1035                1040
Met Pro Pro Pro Gln Val Pro Leu Pro Thr Ser Ser Ile Ser Pro Ala
                1045                1050                1055    
Lys Met Ala Asn Gly Thr Ala Gly Thr Lys Val Ala Leu Arg Lys Thr
            1060                1065                1070        
Lys Gln Ala Ala Glu Lys Ile Ser Ala Asp Lys Ile Ser Lys Glu Ala
        1075                1080                1085            
Leu Leu Glu Cys Ala Asp Leu Leu Ser Ser Ala Leu Thr Glu Pro Val
    1090                1095                1100                
Pro Asn Ser Gln Leu Val Asp Thr Gly His Gln Leu Leu Asp Tyr Cys
1105                1110                1115                1120
Ser Gly Tyr Val Asp Cys Ile Pro Gln Thr Arg Asn Lys Phe Ala Phe
                1125                1130                1135    
Arg Glu Ala Val Ser Lys Leu Glu Leu Ser Leu Gln Glu Leu Gln Val
            1140                1145                1150        
Ser Ser Ala Ala Ala Gly Val Pro Gly Thr Asn Pro Val Leu Asn Asn
        1155                1160                1165            
Leu Leu Ser Cys Val Gln Glu Ile Ser Asp Val Val Gln Arg
    1170                1175                1180        


<210> 5573
<211> 1146
<212> PRT
<213> Homo sapiens

<400> 5573
Met Val Leu Gly Thr Val Leu Leu Pro Pro Asn Thr Tyr Gly Arg Asp
 1               5                  10                  15      
Gln Asp Thr Ser Leu Cys Cys Leu Cys Thr Glu Ala Ser Glu Ser Ala
            20                  25                  30          
Leu Pro Asp Leu Thr Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val
        35                  40                  45              
Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn
    50                  55                  60                  
Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr
65                  70                  75                  80  
Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu
                85                  90                  95      
Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val
            100                 105                 110         
Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Thr Pro
        115                 120                 125             
Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg
    130                 135                 140                 
Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu
145                 150                 155                 160 
Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg
                165                 170                 175     
Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr Thr Ala Asp Gly
            180                 185                 190         
Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr Leu Ala Glu Leu
        195                 200                 205             
Val His His His Ser Thr Val Ala Asp Gly Leu Val Thr Thr Leu His
    210                 215                 220                 
Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr Gly Val Ser Pro
225                 230                 235                 240 
Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met Lys His
                245                 250                 255     
Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys
            260                 265                 270         
Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp Thr Met
        275                 280                 285             
Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys
    290                 295                 300                 
His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr Leu Glu Pro Pro
305                 310                 315                 320 
Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr
                325                 330                 335     
Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val Val Leu Leu Tyr
            340                 345                 350         
Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn
        355                 360                 365             
Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn
    370                 375                 380                 
His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Thr Gly
385                 390                 395                 400 
Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Thr
                405                 410                 415     
Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile Lys Ser Asp Val
            420                 425                 430         
Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly Met Ser
        435                 440                 445             
Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys
    450                 455                 460                 
Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu
465                 470                 475                 480 
Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe
                485                 490                 495     
Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His Asp Ser Ser Ile
            500                 505                 510         
Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala Ser Ser Ser Ser
        515                 520                 525             
Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro Ser Lys Thr Arg
    530                 535                 540                 
Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile Glu Gly Ala Gln
545                 550                 555                 560 
Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro Gly Phe Ile Arg
                565                 570                 575     
Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro Arg Lys Gln Arg
            580                 585                 590         
Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys Glu Thr Cys Phe
        595                 600                 605             
Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe Met Lys Lys Arg
    610                 615                 620                 
Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met Glu
625                 630                 635                 640 
Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn Phe Ser Ser Val
                645                 650                 655     
Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr Pro Ala Gln Gln
            660                 665                 670         
Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly Ser Phe Ala Gln
        675                 680                 685             
Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly Gly Ser Gly Thr
    690                 695                 700                 
Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe Thr Pro Arg Leu
705                 710                 715                 720 
Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro Thr Ala Ser Asp
                725                 730                 735     
Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr Ser Ser Met Ser
            740                 745                 750         
Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr Leu Pro Arg Asn
        755                 760                 765             
Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val Ser Thr Ser Ser
    770                 775                 780                 
Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys
785                 790                 795                 800 
Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu
                805                 810                 815     
Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr Pro Ser Gly Asp
            820                 825                 830         
Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val
        835                 840                 845             
Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly
    850                 855                 860                 
Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro
865                 870                 875                 880 
Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn His Lys Val Pro
                885                 890                 895     
Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala Asp Val Gln Leu
            900                 905                 910         
Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His
        915                 920                 925             
Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro
    930                 935                 940                 
Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro
945                 950                 955                 960 
Ser Ile Cys Ser Asp Pro Thr Glu Glu Pro Thr Ala Leu Thr Ala Gly
                965                 970                 975     
Gln Ser Thr Ser Glu Thr Gln Glu Gly Gly Lys Lys Ala Ala Leu Gly
            980                 985                 990         
Ala Val Pro Ile Ser Gly Lys Ala Gly Arg Pro Val Met Pro Pro Pro
        995                 1000                1005            
Gln Val Pro Leu Pro Thr Ser Ser Ile Ser Pro Ala Lys Met Ala Asn
    1010                1015                1020                
Gly Thr Ala Gly Thr Lys Val Ala Leu Arg Lys Thr Lys Gln Ala Ala
1025                1030                1035                1040
Glu Lys Ile Ser Ala Asp Lys Ile Ser Lys Glu Ala Leu Leu Glu Cys
                1045                1050                1055    
Ala Asp Leu Leu Ser Ser Ala Leu Thr Glu Pro Val Pro Asn Ser Gln
            1060                1065                1070        
Leu Val Asp Thr Gly His Gln Leu Leu Asp Tyr Cys Ser Gly Tyr Val
        1075                1080                1085            
Asp Cys Ile Pro Gln Thr Arg Asn Lys Phe Ala Phe Arg Glu Ala Val
    1090                1095                1100                
Ser Lys Leu Glu Leu Ser Leu Gln Glu Leu Gln Val Ser Ser Ala Ala
1105                1110                1115                1120
Ala Gly Val Pro Gly Thr Asn Pro Val Leu Asn Asn Leu Leu Ser Cys
                1125                1130                1135    
Val Gln Glu Ile Ser Asp Val Val Gln Arg
            1140                1145    


<210> 5574
<211> 573
<212> PRT
<213> Homo sapiens

<400> 5574
Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
                85                  90                  95      
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu
            100                 105                 110         
Tyr Tyr Cys Ala Lys His Gly Ser Gly Ser Tyr Ile Gly Tyr Tyr Tyr
        115                 120                 125             
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
    130                 135                 140                 
Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His
145                 150                 155                 160 
Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr
                165                 170                 175     
His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln
            180                 185                 190         
Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met
        195                 200                 205             
Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu
    210                 215                 220                 
Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile
225                 230                 235                 240 
Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr
                245                 250                 255     
Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro
            260                 265                 270         
Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu
        275                 280                 285             
Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys
    290                 295                 300                 
Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val
305                 310                 315                 320 
Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val
                325                 330                 335     
Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys
            340                 345                 350         
Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn
        355                 360                 365             
Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp
    370                 375                 380                 
Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro
385                 390                 395                 400 
Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val
                405                 410                 415     
Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala
            420                 425                 430         
Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu
        435                 440                 445             
Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala
    450                 455                 460                 
Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp
465                 470                 475                 480 
Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr
                485                 490                 495     
Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser
            500                 505                 510         
Arg Ser Leu Glu Val Ser Tyr Leu Ala Met Thr Pro Leu Ile Pro Gln
        515                 520                 525             
Ser Lys Asp Glu Asn Ser Asp Asp Tyr Thr Thr Phe Asp Asp Val Gly
    530                 535                 540                 
Ser Leu Trp Thr Thr Leu Ser Thr Phe Val Ala Leu Phe Ile Leu Thr
545                 550                 555                 560 
Leu Leu Tyr Ser Gly Ile Val Thr Phe Ile Lys Val Lys
                565                 570             


<210> 5575
<211> 1927
<212> PRT
<213> Homo sapiens

<400> 5575
Met Glu Leu Ser Trp His Val Val Phe Ile Ala Leu Leu Ser Phe Ser
 1               5                  10                  15      
Cys Trp Gly Ser Asp Trp Glu Ser Asp Arg Asn Phe Ile Ser Thr Ala
            20                  25                  30          
Gly Pro Leu Thr Asn Asp Leu Leu His Asn Leu Ser Gly Leu Leu Gly
        35                  40                  45              
Asp Gln Ser Ser Asn Phe Val Ala Gly Asp Lys Asp Met Tyr Val Cys
    50                  55                  60                  
His Gln Pro Leu Pro Thr Phe Leu Pro Glu Tyr Phe Ser Ser Leu His
65                  70                  75                  80  
Ala Ser Gln Ile Thr His Tyr Lys Val Phe Leu Ser Trp Ala Gln Leu
                85                  90                  95      
Leu Pro Ala Gly Ser Thr Gln Asn Pro Asp Glu Lys Thr Val Gln Cys
            100                 105                 110         
Tyr Arg Arg Leu Leu Lys Ala Leu Lys Thr Ala Arg Leu Gln Pro Met
        115                 120                 125             
Val Ile Leu His His Gln Thr Leu Pro Ala Ser Thr Leu Arg Arg Thr
    130                 135                 140                 
Glu Ala Phe Ala Asp Leu Phe Ala Asp Tyr Ala Thr Phe Ala Phe His
145                 150                 155                 160 
Ser Phe Gly Asp Leu Val Gly Ile Trp Phe Thr Phe Ser Asp Leu Glu
                165                 170                 175     
Glu Val Ile Lys Glu Leu Pro His Gln Glu Ser Arg Ala Ser Gln Leu
            180                 185                 190         
Gln Thr Leu Ser Asp Ala His Arg Lys Ala Tyr Glu Ile Tyr His Glu
        195                 200                 205             
Ser Tyr Ala Phe Gln Gly Gly Lys Leu Ser Val Val Leu Arg Ala Glu
    210                 215                 220                 
Asp Ile Pro Glu Leu Leu Leu Glu Pro Pro Ile Ser Ala Leu Ala Gln
225                 230                 235                 240 
Asp Thr Val Asp Phe Leu Ser Leu Asp Leu Ser Tyr Glu Cys Gln Asn
                245                 250                 255     
Glu Ala Ser Leu Arg Gln Lys Leu Ser Lys Leu Gln Thr Ile Glu Pro
            260                 265                 270         
Lys Val Lys Val Phe Ile Phe Asn Leu Lys Leu Pro Asp Cys Pro Ser
        275                 280                 285             
Thr Met Lys Asn Pro Ala Ser Leu Leu Phe Ser Leu Phe Glu Ala Ile
    290                 295                 300                 
Asn Lys Asp Gln Val Leu Thr Ile Gly Phe Asp Ile Asn Glu Phe Leu
305                 310                 315                 320 
Ser Cys Ser Ser Ser Ser Lys Lys Ser Met Ser Cys Ser Leu Thr Gly
                325                 330                 335     
Ser Leu Ala Leu Gln Pro Asp Gln Gln Gln Asp His Glu Thr Thr Asp
            340                 345                 350         
Ser Ser Pro Ala Ser Ala Tyr Gln Arg Val Trp Glu Ala Phe Ala Asn
        355                 360                 365             
Gln Ser Arg Ala Glu Arg Asp Ala Phe Leu Gln Asp Thr Phe Pro Glu
    370                 375                 380                 
Gly Phe Leu Trp Gly Ala Ser Thr Gly Ala Phe Asn Val Glu Gly Gly
385                 390                 395                 400 
Trp Ala Glu Gly Gly Arg Gly Val Ser Ile Trp Asp Pro Arg Arg Pro
                405                 410                 415     
Leu Asn Thr Thr Glu Gly Gln Ala Thr Leu Glu Val Ala Ser Asp Ser
            420                 425                 430         
Tyr His Lys Val Ala Ser Asp Val Ala Leu Leu Cys Gly Leu Arg Ala
        435                 440                 445             
Gln Val Tyr Lys Phe Ser Ile Ser Trp Ser Arg Ile Phe Pro Met Gly
    450                 455                 460                 
His Gly Ser Ser Pro Ser Leu Pro Gly Val Ala Tyr Tyr Asn Lys Leu
465                 470                 475                 480 
Ile Asp Arg Leu Gln Asp Ala Gly Ile Glu Pro Met Ala Thr Leu Phe
                485                 490                 495     
His Trp Asp Leu Pro Gln Ala Leu Gln Asp His Gly Gly Trp Gln Asn
            500                 505                 510         
Glu Ser Val Val Asp Ala Phe Leu Asp Tyr Ala Ala Phe Cys Phe Ser
        515                 520                 525             
Thr Phe Gly Asp Arg Val Lys Leu Trp Val Thr Phe His Glu Pro Trp
    530                 535                 540                 
Val Met Ser Tyr Ala Gly Tyr Gly Thr Gly Gln His Pro Pro Gly Ile
545                 550                 555                 560 
Ser Asp Pro Gly Val Ala Ser Phe Lys Val Ala His Leu Val Leu Lys
                565                 570                 575     
Ala His Ala Arg Thr Trp His His Tyr Asn Ser His His Arg Pro Gln
            580                 585                 590         
Gln Gln Gly His Val Gly Ile Val Leu Asn Ser Asp Trp Ala Glu Pro
        595                 600                 605             
Leu Ser Pro Glu Arg Pro Glu Asp Leu Arg Ala Ser Glu Arg Phe Leu
    610                 615                 620                 
His Phe Met Leu Gly Trp Phe Ala His Pro Val Phe Val Asp Gly Asp
625                 630                 635                 640 
Tyr Pro Ala Thr Leu Arg Thr Gln Ile Gln Gln Met Asn Arg Gln Cys
                645                 650                 655     
Ser His Pro Val Ala Gln Leu Pro Glu Phe Thr Glu Ala Glu Lys Gln
            660                 665                 670         
Leu Leu Lys Gly Ser Ala Asp Phe Leu Gly Leu Ser His Tyr Thr Ser
        675                 680                 685             
Arg Leu Ile Ser Asn Ala Pro Gln Asn Thr Cys Ile Pro Ser Tyr Asp
    690                 695                 700                 
Thr Ile Gly Gly Phe Ser Gln His Val Asn His Val Trp Pro Gln Thr
705                 710                 715                 720 
Ser Ser Ser Trp Ile Arg Val Val Pro Trp Gly Ile Arg Arg Leu Leu
                725                 730                 735     
Gln Phe Val Ser Leu Glu Tyr Thr Arg Gly Lys Val Pro Ile Tyr Leu
            740                 745                 750         
Ala Gly Asn Gly Met Pro Ile Gly Glu Ser Glu Asn Leu Phe Asp Asp
        755                 760                 765             
Ser Leu Arg Val Asp Tyr Phe Asn Gln Tyr Ile Asn Glu Val Leu Lys
    770                 775                 780                 
Ala Ile Lys Glu Asp Ser Val Asp Val Arg Ser Tyr Ile Ala Arg Ser
785                 790                 795                 800 
Leu Ile Asp Gly Phe Glu Gly Pro Ser Gly Tyr Ser Gln Arg Phe Gly
                805                 810                 815     
Leu His His Val Asn Phe Ser Asp Ser Ser Lys Ser Arg Thr Pro Arg
            820                 825                 830         
Lys Ser Ala Tyr Phe Phe Thr Ser Ile Ile Glu Lys Asn Gly Phe Leu
        835                 840                 845             
Thr Lys Gly Ala Lys Arg Leu Leu Pro Pro Asn Thr Val Asn Leu Pro
    850                 855                 860                 
Ser Lys Val Arg Ala Phe Thr Phe Pro Ser Glu Val Pro Ser Lys Ala
865                 870                 875                 880 
Lys Val Val Trp Glu Lys Phe Ser Ser Gln Pro Lys Phe Glu Arg Asp
                885                 890                 895     
Leu Phe Tyr His Gly Thr Phe Arg Asp Asp Phe Leu Trp Gly Val Ser
            900                 905                 910         
Ser Ser Ala Tyr Gln Ile Glu Gly Ala Trp Asp Ala Asp Gly Lys Gly
        915                 920                 925             
Pro Ser Ile Trp Asp Asn Phe Thr His Thr Pro Gly Ser Asn Val Lys
    930                 935                 940                 
Asp Asn Ala Thr Gly Asp Ile Ala Cys Asp Ser Tyr His Gln Leu Asp
945                 950                 955                 960 
Ala Asp Leu Asn Met Leu Arg Ala Leu Lys Val Lys Ala Tyr Arg Phe
                965                 970                 975     
Ser Ile Ser Trp Ser Arg Ile Phe Pro Thr Gly Arg Asn Ser Ser Ile
            980                 985                 990         
Asn Ser His Gly Val Asp Tyr Tyr Asn Arg Leu Ile Asn Gly Leu Val
        995                 1000                1005            
Ala Ser Asn Ile Phe Pro Met Val Thr Leu Phe His Trp Asp Leu Pro
    1010                1015                1020                
Gln Ala Leu Gln Asp Ile Gly Gly Trp Glu Asn Pro Ala Leu Ile Asp
1025                1030                1035                1040
Leu Phe Asp Ser Tyr Ala Asp Phe Cys Phe Gln Thr Phe Gly Asp Arg
                1045                1050                1055    
Val Lys Phe Trp Met Thr Phe Asn Glu Pro Met Tyr Leu Ala Trp Leu
            1060                1065                1070        
Gly Tyr Gly Ser Gly Glu Phe Pro Pro Gly Val Lys Asp Pro Gly Trp
        1075                1080                1085            
Ala Pro Tyr Arg Ile Ala His Thr Val Ile Lys Ala His Ala Arg Val
    1090                1095                1100                
Tyr His Thr Tyr Asp Glu Lys Tyr Arg Gln Glu Gln Lys Gly Val Ile
1105                1110                1115                1120
Ser Leu Ser Leu Ser Thr His Trp Ala Glu Pro Lys Ser Pro Gly Val
                1125                1130                1135    
Pro Arg Asp Val Glu Ala Ala Asp Arg Met Leu Gln Phe Ser Leu Gly
            1140                1145                1150        
Trp Phe Ala His Pro Ile Phe Arg Asn Gly Asp Tyr Pro Asp Thr Met
        1155                1160                1165            
Lys Trp Lys Val Gly Asn Arg Ser Glu Leu Gln His Leu Ala Thr Ser
    1170                1175                1180                
Arg Leu Pro Ser Phe Thr Glu Glu Glu Lys Arg Phe Ile Arg Ala Thr
1185                1190                1195                1200
Ala Asp Val Phe Cys Leu Asn Thr Tyr Tyr Ser Arg Ile Val Gln His
                1205                1210                1215    
Lys Thr Pro Arg Leu Asn Pro Pro Ser Tyr Glu Asp Asp Gln Glu Met
            1220                1225                1230        
Ala Glu Glu Glu Asp Pro Ser Trp Pro Ser Thr Ala Met Asn Arg Ala
        1235                1240                1245            
Ala Pro Trp Gly Thr Arg Arg Leu Leu Asn Trp Ile Lys Glu Glu Tyr
    1250                1255                1260                
Gly Asp Ile Pro Ile Tyr Ile Thr Glu Asn Gly Val Gly Leu Thr Asn
1265                1270                1275                1280
Pro Asn Thr Glu Asp Thr Asp Arg Ile Phe Tyr His Lys Thr Tyr Ile
                1285                1290                1295    
Asn Glu Ala Leu Lys Ala Tyr Arg Leu Asp Gly Ile Asp Leu Arg Gly
            1300                1305                1310        
Tyr Val Ala Trp Ser Leu Met Asp Asn Phe Glu Trp Leu Asn Gly Tyr
        1315                1320                1325            
Thr Val Lys Phe Gly Leu Tyr His Val Asp Phe Asn Asn Thr Asn Arg
    1330                1335                1340                
Pro Arg Thr Ala Arg Ala Ser Ala Arg Tyr Tyr Thr Glu Val Ile Thr
1345                1350                1355                1360
Asn Asn Gly Met Pro Leu Ala Arg Glu Asp Glu Phe Leu Tyr Gly Arg
                1365                1370                1375    
Phe Pro Glu Gly Phe Ile Trp Ser Ala Ala Ser Ala Ala Tyr Gln Ile
            1380                1385                1390        
Glu Gly Ala Trp Arg Ala Asp Gly Lys Gly Leu Ser Ile Trp Asp Thr
        1395                1400                1405            
Phe Ser His Thr Pro Leu Arg Val Glu Asn Asp Ala Ile Gly Asp Val
    1410                1415                1420                
Ala Cys Asp Ser Tyr His Lys Ile Ala Glu Asp Leu Val Thr Leu Gln
1425                1430                1435                1440
Asn Leu Gly Val Ser His Tyr Arg Phe Ser Ile Ser Trp Ser Arg Ile
                1445                1450                1455    
Leu Pro Asp Gly Thr Thr Arg Tyr Ile Asn Glu Ala Gly Leu Asn Tyr
            1460                1465                1470        
Tyr Val Arg Leu Ile Asp Thr Leu Leu Ala Ala Ser Ile Gln Pro Gln
        1475                1480                1485            
Val Thr Ile Tyr His Trp Asp Leu Pro Gln Thr Leu Gln Asp Val Gly
    1490                1495                1500                
Gly Trp Glu Asn Glu Thr Ile Val Gln Arg Phe Lys Glu Tyr Ala Asp
1505                1510                1515                1520
Val Leu Phe Gln Arg Leu Gly Asp Lys Val Lys Phe Trp Ile Thr Leu
                1525                1530                1535    
Asn Glu Pro Phe Val Ile Ala Tyr Gln Gly Tyr Gly Tyr Gly Thr Ala
            1540                1545                1550        
Ala Pro Gly Val Ser Asn Arg Pro Gly Thr Ala Pro Tyr Ile Val Gly
        1555                1560                1565            
His Asn Leu Ile Lys Ala His Ala Glu Ala Trp His Leu Tyr Asn Asp
    1570                1575                1580                
Val Tyr Arg Ala Ser Gln Gly Gly Val Ile Ser Ile Thr Ile Ser Ser
1585                1590                1595                1600
Asp Trp Ala Glu Pro Arg Asp Pro Ser Asn Gln Glu Asp Val Glu Ala
                1605                1610                1615    
Ala Arg Arg Tyr Val Gln Phe Met Gly Gly Trp Phe Ala His Pro Ile
            1620                1625                1630        
Phe Lys Asn Gly Asp Tyr Asn Glu Val Met Lys Thr Arg Ile Arg Asp
        1635                1640                1645            
Arg Ser Leu Ala Ala Gly Leu Asn Lys Ser Arg Leu Pro Glu Phe Thr
    1650                1655                1660                
Glu Ser Glu Lys Arg Arg Ile Asn Gly Thr Tyr Asp Phe Phe Gly Phe
1665                1670                1675                1680
Asn His Tyr Thr Thr Val Leu Ala Tyr Asn Leu Asn Tyr Ala Thr Ala
                1685                1690                1695    
Ile Ser Ser Phe Asp Ala Asp Arg Gly Val Ala Ser Ile Ala Asp Arg
            1700                1705                1710        
Ser Trp Pro Asp Ser Gly Ser Phe Trp Leu Lys Met Thr Pro Phe Gly
        1715                1720                1725            
Phe Arg Arg Ile Leu Asn Trp Leu Lys Glu Glu Tyr Asn Asp Pro Pro
    1730                1735                1740                
Ile Tyr Val Thr Glu Asn Gly Val Ser Gln Arg Glu Glu Thr Asp Leu
1745                1750                1755                1760
Asn Asp Thr Ala Arg Ile Tyr Tyr Leu Arg Thr Tyr Ile Asn Glu Ala
                1765                1770                1775    
Leu Lys Ala Val Gln Asp Lys Val Asp Leu Arg Gly Tyr Thr Val Trp
            1780                1785                1790        
Ser Ala Met Asp Asn Phe Glu Trp Ala Thr Gly Phe Ser Glu Arg Phe
        1795                1800                1805            
Gly Leu His Phe Val Asn Tyr Ser Asp Pro Ser Leu Pro Arg Ile Pro
    1810                1815                1820                
Lys Ala Ser Ala Lys Phe Tyr Ala Ser Val Val Arg Cys Asn Gly Phe
1825                1830                1835                1840
Pro Asp Pro Ala Thr Gly Pro His Ala Cys Leu His Gln Pro Asp Ala
                1845                1850                1855    
Gly Pro Thr Ile Ser Pro Val Arg Gln Glu Glu Val Gln Phe Leu Gly
            1860                1865                1870        
Leu Met Leu Gly Thr Thr Glu Ala Gln Thr Ala Leu Tyr Val Leu Phe
        1875                1880                1885            
Ser Leu Val Leu Leu Gly Val Cys Gly Leu Ala Phe Leu Ser Tyr Lys
    1890                1895                1900                
Tyr Cys Lys Arg Ser Lys Gln Gly Lys Thr Gln Arg Ser Gln Gln Glu
1905                1910                1915                1920
Leu Ser Pro Val Ser Ser Phe
                1925        


<210> 5576
<211> 410
<212> PRT
<213> Homo sapiens

<400> 5576
Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu
 1               5                  10                  15      
Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn
            20                  25                  30          
Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met
        35                  40                  45              
Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val
    50                  55                  60                  
Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly
65                  70                  75                  80  
Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe
                85                  90                  95      
Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp
            100                 105                 110         
Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp
        115                 120                 125             
Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg
    130                 135                 140                 
Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu
145                 150                 155                 160 
Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe
                165                 170                 175     
Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp
            180                 185                 190         
Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro
        195                 200                 205             
Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser
    210                 215                 220                 
Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln
225                 230                 235                 240 
Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro
                245                 250                 255     
Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu
            260                 265                 270         
Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val
        275                 280                 285             
Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr
    290                 295                 300                 
Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr
305                 310                 315                 320 
Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr
                325                 330                 335     
Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val
            340                 345                 350         
Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys
        355                 360                 365             
Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala
    370                 375                 380                 
Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu
385                 390                 395                 400 
Lys His His His Ala Gly Tyr Glu Gln Phe
                405                 410 


<210> 5577
<211> 410
<212> PRT
<213> Homo sapiens

<400> 5577
Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu
 1               5                  10                  15      
Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn
            20                  25                  30          
Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met
        35                  40                  45              
Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val
    50                  55                  60                  
Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly
65                  70                  75                  80  
Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe
                85                  90                  95      
Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp
            100                 105                 110         
Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp
        115                 120                 125             
Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg
    130                 135                 140                 
Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu
145                 150                 155                 160 
Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe
                165                 170                 175     
Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp
            180                 185                 190         
Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro
        195                 200                 205             
Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser
    210                 215                 220                 
Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln
225                 230                 235                 240 
Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro
                245                 250                 255     
Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu
            260                 265                 270         
Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val
        275                 280                 285             
Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr
    290                 295                 300                 
Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr
305                 310                 315                 320 
Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr
                325                 330                 335     
Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val
            340                 345                 350         
Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu Cys
        355                 360                 365             
Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala Gly
    370                 375                 380                 
Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr Val Ile Gly Arg
385                 390                 395                 400 
Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu
                405                 410 


<210> 5578
<211> 1399
<212> PRT
<213> Homo sapiens

<400> 5578
Met Ser Gln Asn Ile Pro Leu Leu Ala Thr Gly Leu Lys Ser Pro Ser
 1               5                  10                  15      
Ser Gly Gly Pro Leu Val Glu Asp Ala Ala Trp Lys His Trp Pro Glu
            20                  25                  30          
Ser Asn Thr Glu Ala His Val Glu Asn Ile Thr Phe Tyr Gln Asn Gln
        35                  40                  45              
Glu Asp Phe Ser Thr Val Ser Ser Lys Glu Gly Val Met Val Gln Thr
    50                  55                  60                  
Ser Gly Lys Ser His Ala Ala Ser Asp Ala Pro Glu Asn Leu Thr Leu
65                  70                  75                  80  
Leu Ala Glu Thr Ala Asp Ala Arg Gly Arg Ser Gly Ser Ser Ser Arg
                85                  90                  95      
Thr Asn Phe Thr Ile Leu Pro Val Gly Tyr Ser Leu Glu Ile Ala Thr
            100                 105                 110         
Ala Leu Thr Ser Gln Ser Gly Asn Leu Ala Ser Glu Ser Leu His Leu
        115                 120                 125             
Pro Ser Ser Ser Ser Glu Phe Asp Glu Arg Ile Ala Ala Phe Gln Thr
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Glu Met Gly Thr Glu Arg Ala Met Gly Leu
145                 150                 155                 160 
Ser Glu Glu Trp Thr Val His Ser Gln Glu Ala Thr Thr Ser Ala Trp
                165                 170                 175     
Ser Pro Ser Phe Leu Pro Ala Leu Glu Met Gly Glu Leu Thr Thr Pro
            180                 185                 190         
Ser Arg Lys Arg Asn Ser Ser Gly Pro Asp Leu Ser Trp Leu His Phe
        195                 200                 205             
Tyr Arg Thr Ala Ala Ser Ser Pro Leu Leu Asp Leu Ser Ser Ser Ser
    210                 215                 220                 
Glu Ser Thr Glu Lys Leu Asn Asn Ser Thr Gly Leu Gln Ser Ser Ser
225                 230                 235                 240 
Val Ser Gln Thr Lys Thr Met His Val Ala Thr Val Phe Thr Asp Gly
                245                 250                 255     
Gly Pro Arg Thr Leu Arg Ser Leu Thr Val Ser Leu Gly Pro Val Ser
            260                 265                 270         
Lys Thr Glu Gly Phe Pro Lys Asp Ser Arg Ile Ala Thr Thr Ser Ser
        275                 280                 285             
Ser Val Leu Leu Ser Pro Ser Ala Val Glu Ser Arg Arg Asn Ser Arg
    290                 295                 300                 
Val Thr Gly Asn Pro Gly Asp Glu Glu Phe Ile Glu Pro Ser Thr Glu
305                 310                 315                 320 
Asn Glu Phe Gly Leu Thr Ser Leu Arg Trp Gln Asn Asp Ser Pro Thr
                325                 330                 335     
Phe Gly Glu His Gln Leu Ala Ser Ser Ser Glu Val Gln Asn Gly Ser
            340                 345                 350         
Pro Met Ser Gln Thr Glu Thr Val Ser Arg Ser Val Ala Pro Met Arg
        355                 360                 365             
Gly Gly Glu Ile Thr Ala His Trp Leu Leu Thr Asn Ser Thr Thr Ser
    370                 375                 380                 
Ala Asp Val Thr Gly Ser Ser Ala Ser Tyr Pro Glu Gly Val Asn Ala
385                 390                 395                 400 
Ser Val Leu Thr Gln Phe Ser Asp Ser Thr Val Gln Ser Gly Gly Ser
                405                 410                 415     
His Thr Ala Leu Gly Asp Arg Ser Tyr Ser Glu Ser Ser Ser Thr Ser
            420                 425                 430         
Ser Ser Glu Ser Leu Asn Ser Ser Ala Pro Arg Gly Glu Arg Ser Thr
        435                 440                 445             
Leu Glu Asp Ser Arg Glu Pro Gly Gln Ala Leu Gly Asp Ser Ser Ala
    450                 455                 460                 
Asn Ala Glu Asp Arg Thr Ser Gly Val Pro Ser Leu Gly Thr His Thr
465                 470                 475                 480 
Leu Ala Thr Val Thr Gly Asn Gly Glu Arg Thr Leu Arg Ser Val Thr
                485                 490                 495     
Leu Thr Asn Thr Ser Met Ser Thr Thr Ser Gly Glu Ala Gly Ser Pro
            500                 505                 510         
Ala Ala Ala Met His Gln Glu Thr Glu Gly Ala Ser Leu His Val Asn
        515                 520                 525             
Val Thr Asp Asp Met Gly Leu Val Ser Arg Ser Leu Ala Ala Ser Ser
    530                 535                 540                 
Ala Leu Gly Val Ala Gly Ile Ser Tyr Gly Gln Val Arg Gly Thr Ala
545                 550                 555                 560 
Ile Glu Gln Arg Thr Ser Ser Asp His Thr Asp His Thr Tyr Leu Ser
                565                 570                 575     
Ser Thr Phe Thr Lys Gly Glu Arg Ala Leu Leu Ser Ile Thr Asp Asn
            580                 585                 590         
Ser Ser Ser Ser Asp Ile Val Glu Ser Ser Thr Ser Tyr Ile Lys Ile
        595                 600                 605             
Ser Asn Ser Ser His Ser Glu Tyr Ser Ser Phe Phe His Ala Gln Thr
    610                 615                 620                 
Glu Arg Ser Asn Ile Ser Ser Tyr Asp Gly Glu Tyr Ala Gln Pro Ser
625                 630                 635                 640 
Thr Glu Ser Pro Val Leu His Thr Ser Asn Leu Pro Ser Tyr Thr Pro
                645                 650                 655     
Thr Ile Asn Met Pro Asn Thr Ser Val Val Leu Asp Thr Asp Ala Glu
            660                 665                 670         
Phe Val Ser Asp Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
        675                 680                 685             
Ser Ser Gly Pro Pro Leu Pro Leu Pro Ser Val Ser Gln Ser His His
    690                 695                 700                 
Leu Phe Ser Ser Ile Leu Pro Ser Thr Arg Ala Ser Val His Leu Leu
705                 710                 715                 720 
Lys Ser Thr Ser Asp Ala Ser Thr Pro Trp Ser Ser Ser Pro Ser Pro
                725                 730                 735     
Leu Pro Val Ser Leu Thr Thr Ser Thr Ser Ala Pro Leu Ser Val Ser
            740                 745                 750         
Gln Thr Thr Leu Pro Gln Ser Ser Ser Thr Pro Val Leu Pro Arg Ala
        755                 760                 765             
Arg Glu Thr Pro Val Thr Ser Phe Gln Thr Ser Thr Met Thr Ser Phe
    770                 775                 780                 
Met Thr Met Leu His Ser Ser Gln Thr Ala Asp Leu Lys Ser Gln Ser
785                 790                 795                 800 
Thr Pro His Gln Glu Lys Val Ile Thr Glu Ser Lys Ser Pro Ser Leu
                805                 810                 815     
Val Ser Leu Pro Thr Glu Ser Thr Lys Ala Val Thr Thr Asn Ser Pro
            820                 825                 830         
Leu Pro Pro Ser Leu Thr Glu Ser Ser Thr Glu Gln Thr Leu Pro Ala
        835                 840                 845             
Thr Ser Thr Asn Leu Ala Gln Met Ser Pro Thr Phe Thr Thr Thr Ile
    850                 855                 860                 
Leu Lys Thr Ser Gln Pro Leu Met Thr Thr Pro Gly Thr Leu Ser Ser
865                 870                 875                 880 
Thr Ala Ser Leu Val Thr Gly Pro Ile Ala Val Gln Thr Thr Ala Gly
                885                 890                 895     
Lys Gln Leu Ser Leu Thr His Pro Glu Ile Leu Val Pro Gln Ile Ser
            900                 905                 910         
Thr Glu Gly Gly Ile Ser Thr Glu Arg Asn Arg Val Ile Val Asp Ala
        915                 920                 925             
Thr Thr Gly Leu Ile Pro Leu Thr Ser Val Pro Thr Ser Ala Lys Glu
    930                 935                 940                 
Met Thr Thr Lys Leu Gly Val Thr Ala Glu Tyr Ser Pro Ala Ser Arg
945                 950                 955                 960 
Ser Leu Gly Thr Ser Pro Ser Pro Gln Thr Thr Val Val Ser Thr Ala
                965                 970                 975     
Glu Asp Leu Ala Pro Lys Ser Ala Thr Phe Ala Val Gln Ser Ser Thr
            980                 985                 990         
Gln Ser Pro Thr Thr Val Ser Ser Ser Ala Ser Val Asn Ser Cys Ala
        995                 1000                1005            
Val Asn Pro Cys Leu His Asn Gly Glu Cys Val Ala Asp Asn Thr Ser
    1010                1015                1020                
Arg Gly Tyr His Cys Arg Cys Pro Pro Ser Trp Gln Gly Asp Asp Cys
1025                1030                1035                1040
Ser Val Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Pro Ser Thr Ala
                1045                1050                1055    
Met Cys Asn Asn Thr Gln Gly Ser Phe Ile Cys Lys Cys Pro Val Gly
            1060                1065                1070        
Tyr Gln Leu Glu Lys Gly Ile Cys Asn Leu Val Arg Thr Phe Val Thr
        1075                1080                1085            
Glu Phe Lys Leu Lys Arg Thr Phe Leu Asn Thr Thr Val Glu Lys His
    1090                1095                1100                
Ser Asp Leu Gln Glu Val Glu Asn Glu Ile Thr Lys Thr Leu Asn Met
1105                1110                1115                1120
Cys Phe Ser Ala Leu Pro Ser Tyr Ile Arg Ser Thr Val His Ala Ser
                1125                1130                1135    
Arg Glu Ser Asn Ala Val Val Ile Ser Leu Gln Thr Thr Phe Ser Leu
            1140                1145                1150        
Ala Ser Asn Val Thr Leu Phe Asp Leu Ala Asp Arg Met Gln Lys Cys
        1155                1160                1165            
Val Asn Ser Cys Lys Ser Ser Ala Glu Val Cys Gln Leu Leu Gly Ser
    1170                1175                1180                
Gln Arg Arg Ile Phe Arg Ala Gly Ser Leu Cys Lys Arg Lys Ser Pro
1185                1190                1195                1200
Glu Cys Asp Lys Asp Thr Ser Ile Cys Thr Asp Leu Asp Gly Val Ala
                1205                1210                1215    
Leu Cys Gln Cys Lys Ser Gly Tyr Phe Gln Phe Asn Lys Met Asp His
            1220                1225                1230        
Ser Cys Arg Ala Cys Glu Asp Gly Tyr Arg Leu Glu Asn Glu Thr Cys
        1235                1240                1245            
Met Ser Cys Pro Phe Gly Leu Gly Gly Leu Asn Cys Gly Asn Pro Tyr
    1250                1255                1260                
Gln Leu Ile Thr Val Val Ile Ala Ala Ala Gly Gly Gly Leu Leu Leu
1265                1270                1275                1280
Ile Leu Gly Ile Ala Leu Ile Val Thr Cys Cys Arg Lys Asn Lys Asn
                1285                1290                1295    
Asp Ile Ser Lys Leu Ile Phe Lys Ser Gly Asp Phe Gln Met Ser Pro
            1300                1305                1310        
Tyr Ala Glu Tyr Pro Lys Asn Pro Arg Ser Gln Glu Trp Gly Arg Glu
        1315                1320                1325            
Ala Ile Glu Met His Glu Asn Gly Ser Thr Lys Asn Leu Leu Gln Met
    1330                1335                1340                
Thr Asp Val Tyr Tyr Ser Pro Thr Ser Val Arg Asn Pro Glu Leu Glu
1345                1350                1355                1360
Arg Asn Gly Leu Tyr Pro Ala Tyr Thr Gly Leu Pro Gly Ser Arg His
                1365                1370                1375    
Ser Cys Ile Phe Pro Gly Gln Tyr Asn Pro Ser Phe Ile Ser Asp Glu
            1380                1385                1390        
Ser Arg Arg Arg Asp Tyr Phe
        1395                


<210> 5579
<211> 302
<212> PRT
<213> Homo sapiens

<400> 5579
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu
 1               5                  10                  15      
Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp
            20                  25                  30          
Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn
        35                  40                  45              
Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr
    50                  55                  60                  
Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr
65                  70                  75                  80  
Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe
                85                  90                  95      
Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His
            100                 105                 110         
Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val
        115                 120                 125             
Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser
    130                 135                 140                 
Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser
145                 150                 155                 160 
Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp
                165                 170                 175     
Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn
            180                 185                 190         
Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr
        195                 200                 205             
Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln
    210                 215                 220                 
Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp
225                 230                 235                 240 
Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr
                245                 250                 255     
Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala
            260                 265                 270         
Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly
        275                 280                 285             
Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val
    290                 295                 300         


<210> 5580
<211> 309
<212> PRT
<213> Homo sapiens

<400> 5580
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu
 1               5                  10                  15      
Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp
            20                  25                  30          
Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn
        35                  40                  45              
Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr
    50                  55                  60                  
Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr
65                  70                  75                  80  
Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe
                85                  90                  95      
Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His
            100                 105                 110         
Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val
        115                 120                 125             
Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser
    130                 135                 140                 
Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser
145                 150                 155                 160 
Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp
                165                 170                 175     
Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn
            180                 185                 190         
Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr
        195                 200                 205             
Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln
    210                 215                 220                 
Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp
225                 230                 235                 240 
Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr
                245                 250                 255     
Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala
            260                 265                 270         
Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly
        275                 280                 285             
Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Glu Ser Trp Asn Leu
    290                 295                 300                 
Leu Leu Leu Leu Ser
305                 


<210> 5581
<211> 540
<212> PRT
<213> Homo sapiens

<400> 5581
Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val
 1               5                  10                  15      
Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln
            20                  25                  30          
Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser
        35                  40                  45              
Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln
    50                  55                  60                  
His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser
65                  70                  75                  80  
Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu
                85                  90                  95      
Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro
            100                 105                 110         
Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu
        115                 120                 125             
Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser
    130                 135                 140                 
Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp
145                 150                 155                 160 
Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn
                165                 170                 175     
Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro
            180                 185                 190         
Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu
        195                 200                 205             
Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg
    210                 215                 220                 
Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala
225                 230                 235                 240 
Met Ser Arg Phe Cys Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His
                245                 250                 255     
Trp Cys Cys Thr Arg Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu
            260                 265                 270         
Glu Ala Pro Gln Pro His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln
        275                 280                 285             
Pro Asp Ile Ser Ser Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro
    290                 295                 300                 
Thr Leu Asp Asn Ile Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser
305                 310                 315                 320 
Val Pro Arg Asn Leu Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu
                325                 330                 335     
Ala Leu Ile Gln Leu Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly
            340                 345                 350         
Asn Asn His Thr Cys Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys
        355                 360                 365             
Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His Leu Cys Cys
    370                 375                 380                 
Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala
385                 390                 395                 400 
Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp Ile Ser Arg
                405                 410                 415     
Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln Arg Val Leu
            420                 425                 430         
Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg
        435                 440                 445             
Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu
    450                 455                 460                 
Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp
465                 470                 475                 480 
Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val
                485                 490                 495     
Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly
            500                 505                 510         
Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly
        515                 520                 525             
Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu
    530                 535                 540 


<210> 5582
<211> 415
<212> PRT
<213> Homo sapiens

<400> 5582
Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val
 1               5                  10                  15      
Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln
            20                  25                  30          
Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser
        35                  40                  45              
Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln
    50                  55                  60                  
His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser
65                  70                  75                  80  
Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu
                85                  90                  95      
Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro
            100                 105                 110         
Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu
        115                 120                 125             
Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser
    130                 135                 140                 
Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp
145                 150                 155                 160 
Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn
                165                 170                 175     
Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro
            180                 185                 190         
Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu
        195                 200                 205             
Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg
    210                 215                 220                 
Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Asp Thr
225                 230                 235                 240 
Leu Asp Lys Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His
                245                 250                 255     
Leu Cys Cys Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala
            260                 265                 270         
Arg Arg Ala Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp
        275                 280                 285             
Ile Ser Arg Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln
    290                 295                 300                 
Arg Val Leu Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met
305                 310                 315                 320 
Thr Ala Arg Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala
                325                 330                 335     
Glu Glu Glu Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg
            340                 345                 350         
Asn Ile Trp Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp
        355                 360                 365             
Glu Gln Val Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu
    370                 375                 380                 
Val Ser Gly Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser
385                 390                 395                 400 
Thr Gly Gly Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu
                405                 410                 415 


<210> 5583
<211> 4548
<212> PRT
<213> Homo sapiens

<400> 5583
Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser
 1               5                  10                  15      
Ala Ala Pro Glu Gln Ser His Val Val Gln Asp Cys Tyr His Gly Asp
            20                  25                  30          
Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr
        35                  40                  45              
Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Asn Arg Thr Thr
    50                  55                  60                  
Glu Asn Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro
65                  70                  75                  80  
Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg
                85                  90                  95      
Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala
            100                 105                 110         
Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser
        115                 120                 125             
Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His
    130                 135                 140                 
Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly
145                 150                 155                 160 
Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg
                165                 170                 175     
Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg
            180                 185                 190         
Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly
        195                 200                 205             
Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly
    210                 215                 220                 
Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala
225                 230                 235                 240 
Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys
                245                 250                 255     
Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val
            260                 265                 270         
Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His
        275                 280                 285             
Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr
    290                 295                 300                 
Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp
305                 310                 315                 320 
Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala
                325                 330                 335     
Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu
            340                 345                 350         
Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln
        355                 360                 365             
Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr
    370                 375                 380                 
Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His
385                 390                 395                 400 
Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met
                405                 410                 415     
Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr
            420                 425                 430         
Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser
        435                 440                 445             
Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro
    450                 455                 460                 
Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly
465                 470                 475                 480 
Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr
                485                 490                 495     
Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr
            500                 505                 510         
Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu
        515                 520                 525             
Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys
    530                 535                 540                 
Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln
545                 550                 555                 560 
Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro
                565                 570                 575     
Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg
            580                 585                 590         
Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly
        595                 600                 605             
Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser
    610                 615                 620                 
Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala
625                 630                 635                 640 
Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro
                645                 650                 655     
Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu
            660                 665                 670         
Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val
        675                 680                 685             
Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu
    690                 695                 700                 
Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr
705                 710                 715                 720 
Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp
                725                 730                 735     
Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro
            740                 745                 750         
Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala
        755                 760                 765             
Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys
    770                 775                 780                 
Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro
785                 790                 795                 800 
Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro
                805                 810                 815     
Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln
            820                 825                 830         
Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln
        835                 840                 845             
Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr
    850                 855                 860                 
Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala
865                 870                 875                 880 
Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu
                885                 890                 895     
Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala
            900                 905                 910         
Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln
        915                 920                 925             
Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn
    930                 935                 940                 
Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr
945                 950                 955                 960 
Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro
                965                 970                 975     
Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro
            980                 985                 990         
Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg
        995                 1000                1005            
Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala
    1010                1015                1020                
Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser
1025                1030                1035                1040
Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His
                1045                1050                1055    
Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly
            1060                1065                1070        
Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg
        1075                1080                1085            
Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg
    1090                1095                1100                
Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly
1105                1110                1115                1120
Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly
                1125                1130                1135    
Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala
            1140                1145                1150        
Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys
        1155                1160                1165            
Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val
    1170                1175                1180                
Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His
1185                1190                1195                1200
Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr
                1205                1210                1215    
Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp
            1220                1225                1230        
Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala
        1235                1240                1245            
Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu
    1250                1255                1260                
Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln
1265                1270                1275                1280
Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr
                1285                1290                1295    
Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His
            1300                1305                1310        
Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met
        1315                1320                1325            
Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr
    1330                1335                1340                
Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser
1345                1350                1355                1360
Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro
                1365                1370                1375    
Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly
            1380                1385                1390        
Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr
        1395                1400                1405            
Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr
    1410                1415                1420                
Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu
1425                1430                1435                1440
Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys
                1445                1450                1455    
Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln
            1460                1465                1470        
Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro
        1475                1480                1485            
Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg
    1490                1495                1500                
Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly
1505                1510                1515                1520
Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser
                1525                1530                1535    
Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala
            1540                1545                1550        
Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro
        1555                1560                1565            
Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu
    1570                1575                1580                
Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val
1585                1590                1595                1600
Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu
                1605                1610                1615    
Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr
            1620                1625                1630        
Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp
        1635                1640                1645            
Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro
    1650                1655                1660                
Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala
1665                1670                1675                1680
Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys
                1685                1690                1695    
Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro
            1700                1705                1710        
Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro
        1715                1720                1725            
Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln
    1730                1735                1740                
Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln
1745                1750                1755                1760
Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr
                1765                1770                1775    
Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala
            1780                1785                1790        
Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu
        1795                1800                1805            
Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala
    1810                1815                1820                
Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln
1825                1830                1835                1840
Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn
                1845                1850                1855    
Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr
            1860                1865                1870        
Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro
        1875                1880                1885            
Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro
    1890                1895                1900                
Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg
1905                1910                1915                1920
Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala
                1925                1930                1935    
Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser
            1940                1945                1950        
Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His
        1955                1960                1965            
Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly
    1970                1975                1980                
Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg
1985                1990                1995                2000
Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg
                2005                2010                2015    
Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly
            2020                2025                2030        
Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly
        2035                2040                2045            
Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala
    2050                2055                2060                
Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys
2065                2070                2075                2080
Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val
                2085                2090                2095    
Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His
            2100                2105                2110        
Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr
        2115                2120                2125            
Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp
    2130                2135                2140                
Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala
2145                2150                2155                2160
Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu
                2165                2170                2175    
Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln
            2180                2185                2190        
Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr
        2195                2200                2205            
Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His
    2210                2215                2220                
Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met
2225                2230                2235                2240
Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr
                2245                2250                2255    
Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser
            2260                2265                2270        
Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro
        2275                2280                2285            
Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly
    2290                2295                2300                
Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr
2305                2310                2315                2320
Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr
                2325                2330                2335    
Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu
            2340                2345                2350        
Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys
        2355                2360                2365            
Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln
    2370                2375                2380                
Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro
2385                2390                2395                2400
Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg
                2405                2410                2415    
Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly
            2420                2425                2430        
Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser
        2435                2440                2445            
Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala
    2450                2455                2460                
Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro
2465                2470                2475                2480
Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu
                2485                2490                2495    
Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val
            2500                2505                2510        
Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu
        2515                2520                2525            
Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr
    2530                2535                2540                
Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp
2545                2550                2555                2560
Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro
                2565                2570                2575    
Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala
            2580                2585                2590        
Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys
        2595                2600                2605            
Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro
    2610                2615                2620                
Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro
2625                2630                2635                2640
Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln
                2645                2650                2655    
Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln
            2660                2665                2670        
Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr
        2675                2680                2685            
Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala
    2690                2695                2700                
Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu
2705                2710                2715                2720
Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala
                2725                2730                2735    
Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln
            2740                2745                2750        
Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn
        2755                2760                2765            
Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr
    2770                2775                2780                
Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro
2785                2790                2795                2800
Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro
                2805                2810                2815    
Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg
            2820                2825                2830        
Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala
        2835                2840                2845            
Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser
    2850                2855                2860                
Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His
2865                2870                2875                2880
Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly
                2885                2890                2895    
Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg
            2900                2905                2910        
Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg
        2915                2920                2925            
Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly
    2930                2935                2940                
Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly
2945                2950                2955                2960
Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala
                2965                2970                2975    
Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys
            2980                2985                2990        
Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val
        2995                3000                3005            
Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His
    3010                3015                3020                
Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr
3025                3030                3035                3040
Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp
                3045                3050                3055    
Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala
            3060                3065                3070        
Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu
        3075                3080                3085            
Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln
    3090                3095                3100                
Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr
3105                3110                3115                3120
Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His
                3125                3130                3135    
Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met
            3140                3145                3150        
Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr
        3155                3160                3165            
Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser
    3170                3175                3180                
Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro
3185                3190                3195                3200
Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly
                3205                3210                3215    
Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr
            3220                3225                3230        
Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr
        3235                3240                3245            
Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu
    3250                3255                3260                
Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys
3265                3270                3275                3280
Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln
                3285                3290                3295    
Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro
            3300                3305                3310        
Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg
        3315                3320                3325            
Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly
    3330                3335                3340                
Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser
3345                3350                3355                3360
Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala
                3365                3370                3375    
Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Pro Val Ala Ala Pro
            3380                3385                3390        
Tyr Cys Tyr Thr Arg Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu
        3395                3400                3405            
Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Ile
    3410                3415                3420                
Thr Pro Ile Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu
3425                3430                3435                3440
Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr
                3445                3450                3455    
Gln Gly Thr Tyr Phe Ile Thr Val Thr Gly Arg Thr Cys Gln Ala Trp
            3460                3465                3470        
Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Ala Tyr Tyr Pro
        3475                3480                3485            
Asn Ala Gly Leu Ile Lys Asn Tyr Cys Arg Asn Pro Asp Pro Val Ala
    3490                3495                3500                
Ala Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys
3505                3510                3515                3520
Asn Leu Thr Arg Cys Ser Asp Ala Glu Trp Thr Ala Phe Val Pro Pro
                3525                3530                3535    
Asn Val Ile Leu Ala Pro Ser Leu Glu Ala Phe Phe Glu Gln Ala Leu
            3540                3545                3550        
Thr Glu Glu Thr Pro Gly Val Gln Asp Cys Tyr Tyr His Tyr Gly Gln
        3555                3560                3565            
Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln
    3570                3575                3580                
Ala Trp Ser Ser Met Thr Pro His Gln His Ser Arg Thr Pro Glu Asn
3585                3590                3595                3600
Tyr Pro Asn Ala Gly Leu Thr Arg Asn Tyr Cys Arg Asn Pro Asp Ala
                3605                3610                3615    
Glu Ile Arg Pro Trp Cys Tyr Thr Met Asp Pro Ser Val Arg Trp Glu
            3620                3625                3630        
Tyr Cys Asn Leu Thr Gln Cys Leu Val Thr Glu Ser Ser Val Leu Ala
        3635                3640                3645            
Thr Leu Thr Val Val Pro Asp Pro Ser Thr Glu Ala Ser Ser Glu Glu
    3650                3655                3660                
Ala Pro Thr Glu Gln Ser Pro Gly Val Gln Asp Cys Tyr His Gly Asp
3665                3670                3675                3680
Gly Gln Ser Tyr Arg Gly Ser Phe Ser Thr Thr Val Thr Gly Arg Thr
                3685                3690                3695    
Cys Gln Ser Trp Ser Ser Met Thr Pro His Trp His Gln Arg Thr Thr
            3700                3705                3710        
Glu Tyr Tyr Pro Asn Gly Gly Leu Thr Arg Asn Tyr Cys Arg Asn Pro
        3715                3720                3725            
Asp Ala Glu Ile Ser Pro Trp Cys Tyr Thr Met Asp Pro Asn Val Arg
    3730                3735                3740                
Trp Glu Tyr Cys Asn Leu Thr Gln Cys Pro Val Thr Glu Ser Ser Val
3745                3750                3755                3760
Leu Ala Thr Ser Thr Ala Val Ser Glu Gln Ala Pro Thr Glu Gln Ser
                3765                3770                3775    
Pro Thr Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly
            3780                3785                3790        
Ser Phe Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ser Trp Ser Ser
        3795                3800                3805            
Met Thr Pro His Trp His Gln Arg Thr Thr Glu Tyr Tyr Pro Asn Gly
    3810                3815                3820                
Gly Leu Thr Arg Asn Tyr Cys Arg Asn Pro Asp Ala Glu Ile Arg Pro
3825                3830                3835                3840
Trp Cys Tyr Thr Met Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu
                3845                3850                3855    
Thr Gln Cys Pro Val Met Glu Ser Thr Leu Leu Thr Thr Pro Thr Val
            3860                3865                3870        
Val Pro Val Pro Ser Thr Glu Leu Pro Ser Glu Glu Ala Pro Thr Glu
        3875                3880                3885            
Asn Ser Thr Gly Val Gln Asp Cys Tyr Arg Gly Asp Gly Gln Ser Tyr
    3890                3895                3900                
Arg Gly Thr Leu Ser Thr Thr Ile Thr Gly Arg Thr Cys Gln Ser Trp
3905                3910                3915                3920
Ser Ser Met Thr Pro His Trp His Arg Arg Ile Pro Leu Tyr Tyr Pro
                3925                3930                3935    
Asn Ala Gly Leu Thr Arg Asn Tyr Cys Arg Asn Pro Asp Ala Glu Ile
            3940                3945                3950        
Arg Pro Trp Cys Tyr Thr Met Asp Pro Ser Val Arg Trp Glu Tyr Cys
        3955                3960                3965            
Asn Leu Thr Arg Cys Pro Val Thr Glu Ser Ser Val Leu Thr Thr Pro
    3970                3975                3980                
Thr Val Ala Pro Val Pro Ser Thr Glu Ala Pro Ser Glu Gln Ala Pro
3985                3990                3995                4000
Pro Glu Lys Ser Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Arg
                4005                4010                4015    
Ser Tyr Arg Gly Ile Ser Ser Thr Thr Val Thr Gly Arg Thr Cys Gln
            4020                4025                4030        
Ser Trp Ser Ser Met Ile Pro His Trp His Gln Arg Thr Pro Glu Asn
        4035                4040                4045            
Tyr Pro Asn Ala Gly Leu Thr Glu Asn Tyr Cys Arg Asn Pro Asp Ser
    4050                4055                4060                
Gly Lys Gln Pro Trp Cys Tyr Thr Thr Asp Pro Cys Val Arg Trp Glu
4065                4070                4075                4080
Tyr Cys Asn Leu Thr Gln Cys Ser Glu Thr Glu Ser Gly Val Leu Glu
                4085                4090                4095    
Thr Pro Thr Val Val Pro Val Pro Ser Met Glu Ala His Ser Glu Ala
            4100                4105                4110        
Ala Pro Thr Glu Gln Thr Pro Val Val Arg Gln Cys Tyr His Gly Asn
        4115                4120                4125            
Gly Gln Ser Tyr Arg Gly Thr Phe Ser Thr Thr Val Thr Gly Arg Thr
    4130                4135                4140                
Cys Gln Ser Trp Ser Ser Met Thr Pro His Arg His Gln Arg Thr Pro
4145                4150                4155                4160
Glu Asn Tyr Pro Asn Asp Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro
                4165                4170                4175    
Asp Ala Asp Thr Gly Pro Trp Cys Phe Thr Met Asp Pro Ser Ile Arg
            4180                4185                4190        
Trp Glu Tyr Cys Asn Leu Thr Arg Cys Ser Asp Thr Glu Gly Thr Val
        4195                4200                4205            
Val Ala Pro Pro Thr Val Ile Gln Val Pro Ser Leu Gly Pro Pro Ser
    4210                4215                4220                
Glu Gln Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Lys
4225                4230                4235                4240
Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Glu Trp Ala Ala Gln Glu
                4245                4250                4255    
Pro His Arg His Ser Thr Phe Ile Pro Gly Thr Asn Lys Trp Ala Gly
            4260                4265                4270        
Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ile Asn Gly Pro
        4275                4280                4285            
Trp Cys Tyr Thr Met Asn Pro Arg Lys Leu Phe Asp Tyr Cys Asp Ile
    4290                4295                4300                
Pro Leu Cys Ala Ser Ser Ser Phe Asp Cys Gly Lys Pro Gln Val Glu
4305                4310                4315                4320
Pro Lys Lys Cys Pro Gly Ser Ile Val Gly Gly Cys Val Ala His Pro
                4325                4330                4335    
His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Lys His
            4340                4345                4350        
Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala
        4355                4360                4365            
His Cys Leu Lys Lys Ser Ser Arg Pro Ser Ser Tyr Lys Val Ile Leu
    4370                4375                4380                
Gly Ala His Gln Glu Val Asn Leu Glu Ser His Val Gln Glu Ile Glu
4385                4390                4395                4400
Val Ser Arg Leu Phe Leu Glu Pro Thr Gln Ala Asp Ile Ala Leu Leu
                4405                4410                4415    
Lys Leu Ser Arg Pro Ala Val Ile Thr Asp Lys Val Met Pro Ala Cys
            4420                4425                4430        
Leu Pro Ser Pro Asp Tyr Met Val Thr Ala Arg Thr Glu Cys Tyr Ile
        4435                4440                4445            
Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Thr Gly Leu Leu Lys
    4450                4455                4460                
Glu Ala Gln Leu Leu Val Ile Glu Asn Glu Val Cys Asn His Tyr Lys
4465                4470                4475                4480
Tyr Ile Cys Ala Glu His Leu Ala Arg Gly Thr Asp Ser Cys Gln Gly
                4485                4490                4495    
Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu
            4500                4505                4510        
Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro
        4515                4520                4525            
Gly Val Tyr Ala Arg Val Ser Arg Phe Val Thr Trp Ile Glu Gly Met
    4530                4535                4540                
Met Arg Asn Asn
4545            


<210> 5584
<211> 93
<212> PRT
<213> Homo sapiens

<400> 5584
Gly Leu Thr Arg Asn Tyr Cys Arg Asn Pro Asp Ala Glu Ile Arg Pro
 1               5                  10                  15      
Trp Cys Tyr Thr Met Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu
            20                  25                  30          
Thr Arg Cys Pro Val Thr Glu Ser Thr Pro Pro Glu Lys Ser Pro Val
        35                  40                  45              
Val Gln Asp Cys Tyr His Gly Asp Gly Arg Ser Tyr Arg Gly Ile Ser
    50                  55                  60                  
Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ser Trp Ser Ser Met Ile
65                  70                  75                  80  
Pro His Trp His Gln Arg Thr Pro Glu Asn Tyr Pro Asn
                85                  90              


<210> 5585
<211> 89
<212> PRT
<213> Homo sapiens

<400> 5585
Ile Ser Ser Gly Leu Ile Lys Asn Tyr Cys Arg Asn Pro Asp Pro Val
 1               5                  10                  15      
Ala Ala Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr
            20                  25                  30          
Cys Asn Leu Thr Arg Cys Ser Asp Ala Glu Trp Thr Ala Phe Asp Cys
        35                  40                  45              
Tyr Tyr His Tyr Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val
    50                  55                  60                  
Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His
65                  70                  75                  80  
Ser Arg Thr Pro Glu Asn Tyr Pro Asn
                85                  


<210> 5586
<211> 398
<212> PRT
<213> Homo sapiens

<400> 5586
Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr
 1               5                  10                  15      
Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr
            20                  25                  30          
Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu
        35                  40                  45              
Thr Glu Asn Tyr Cys Arg Asn Pro Asp Ser Gly Lys Gln Pro Trp Cys
    50                  55                  60                  
Tyr Thr Thr Asp Pro Cys Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln
65                  70                  75                  80  
Cys Ser Glu Thr Glu Ser Ala Pro Thr Glu Gln Thr Pro Val Val Arg
                85                  90                  95      
Gln Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Phe Ser Thr
            100                 105                 110         
Thr Val Thr Gly Arg Thr Cys Gln Ser Trp Ser Ser Met Thr Pro His
        115                 120                 125             
Arg His Gln Arg Thr Pro Glu Asn Tyr Pro Asn Asp Gly Leu Thr Met
    130                 135                 140                 
Asn Tyr Cys Arg Asn Pro Asp Ala Asp Thr Gly Pro Trp Cys Phe Thr
145                 150                 155                 160 
Met Asp Pro Ser Ile Arg Trp Glu Tyr Cys Asn Leu Thr Arg Cys Ser
                165                 170                 175     
Asp Thr Glu Gly Thr Val Val Ala Pro Pro Thr Val Ile Gln Val Pro
            180                 185                 190         
Ser Leu Gly Pro Pro Ser Glu Gln Gly Pro Ser Val Gln Glu Cys Tyr
        195                 200                 205             
His Ser Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Phe Thr Thr Val Thr
    210                 215                 220                 
Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Ser
225                 230                 235                 240 
Arg Thr Pro Glu Lys Tyr Pro Asn Asp Gly Leu Ile Ser Asn Tyr Cys
                245                 250                 255     
Arg Asn Pro Asp Cys Ser Ala Gly Pro Trp Cys Tyr Thr Thr Asp Pro
            260                 265                 270         
Lys Val Arg Trp Glu Tyr Cys Asn Leu Thr Gly Cys Ser Asp Lys Asn
        275                 280                 285             
Arg Ala Val Ala Ala Pro Leu Thr Ile Ile Pro Val Pro Arg Arg Glu
    290                 295                 300                 
Asp Thr Ser Lys Gln Ala Pro Thr Glu Gln Thr Pro Val Val Arg Gln
305                 310                 315                 320 
Cys Tyr His Gly Asn Gly Gln Ser Tyr Gln Gly Thr Phe Ser Thr Thr
                325                 330                 335     
Val Thr Gly Arg Thr Cys Gln Ser Trp Ser Ser Met Thr Pro His Arg
            340                 345                 350         
His Gln Arg Thr Pro Glu Asn Tyr Pro Asn Asp Gly Leu Thr Met Asn
        355                 360                 365             
Tyr Cys Arg Asn Pro Asp Ala Asp Thr Gly Pro Trp Cys Phe Thr Thr
    370                 375                 380                 
Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu Thr Arg Cys
385                 390                 395             


<210> 5587
<211> 113
<212> PRT
<213> Homo sapiens

<400> 5587
Pro Thr Glu Gln Ser Pro Thr Val Gln Asp Cys Tyr His Gly Asp Gly
 1               5                  10                  15      
Gln Ser Tyr Arg Gly Ser Phe Ser Thr Thr Val Thr Gly Arg Thr Cys
            20                  25                  30          
Gln Ser Trp Ser Ser Met Thr Pro His Trp His Gln Arg Thr Thr Glu
        35                  40                  45              
Tyr Tyr Pro Asn Gly Gly Leu Thr Arg Asn Tyr Cys Arg Asn Pro Asp
    50                  55                  60                  
Ala Glu Ile Arg Pro Trp Cys Tyr Thr Met Asp Pro Ser Val Arg Trp
65                  70                  75                  80  
Glu Tyr Cys Asn Leu Thr Arg Cys Pro Val Thr Glu Ser Ser Val Leu
                85                  90                  95      
Thr Thr Pro Thr Val Ala Pro Val Pro Ser Thr Glu Ala Pro Ser Glu
            100                 105                 110         
Gln
    


<210> 5588
<211> 132
<212> PRT
<213> Homo sapiens

<400> 5588
Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser
 1               5                  10                  15      
Ala Pro Thr Glu Thr Gly Pro Ser Val Gln Glu Cys Tyr His Ser Asn
            20                  25                  30          
Gly Gln Ser Tyr Arg Gly Thr Tyr Phe Thr Thr Val Thr Gly Arg Thr
        35                  40                  45              
Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Ser Arg Thr Pro
    50                  55                  60                  
Glu Lys Tyr Pro Asn Asp Gly Leu Ile Ser Asn Tyr Cys Arg Asn Pro
65                  70                  75                  80  
Asp Cys Ser Ala Gly Pro Trp Cys Tyr Thr Thr Asp Pro Asn Val Arg
                85                  90                  95      
Trp Glu Tyr Cys Asn Leu Thr Arg Cys Ser Asp Asp Glu Gly Thr Val
            100                 105                 110         
Phe Val Pro Leu Thr Val Ile Pro Val Pro Ser Leu Glu Asp Ser Phe
        115                 120                 125             
Ile Gln Val Ala
    130         


<210> 5589
<211> 560
<212> PRT
<213> Homo sapiens

<400> 5589
Met Leu Arg Gly Thr Leu Leu Cys Ala Val Leu Gly Leu Leu Arg Ala
 1               5                  10                  15      
Gln Pro Phe Pro Cys Pro Pro Ala Cys Lys Cys Val Phe Arg Asp Ala
            20                  25                  30          
Ala Gln Cys Ser Gly Gly Asp Val Ala Arg Ile Ser Ala Leu Gly Leu
        35                  40                  45              
Pro Thr Asn Leu Thr His Ile Leu Leu Phe Gly Met Gly Arg Gly Val
    50                  55                  60                  
Leu Gln Ser Gln Ser Phe Ser Gly Met Thr Val Leu Gln Arg Leu Met
65                  70                  75                  80  
Ile Ser Asp Ser His Ile Ser Ala Val Ala Pro Gly Thr Phe Ser Asp
                85                  90                  95      
Leu Ile Lys Leu Lys Thr Leu Arg Leu Ser Arg Asn Lys Ile Thr His
            100                 105                 110         
Leu Pro Gly Ala Leu Leu Asp Lys Met Val Leu Leu Glu Gln Leu Phe
        115                 120                 125             
Leu Asp His Asn Ala Leu Arg Gly Ile Asp Gln Asn Met Phe Gln Lys
    130                 135                 140                 
Leu Val Asn Leu Gln Glu Leu Ala Leu Asn Gln Asn Gln Leu Asp Phe
145                 150                 155                 160 
Leu Pro Ala Ser Leu Phe Thr Asn Leu Glu Asn Leu Lys Leu Leu Asp
                165                 170                 175     
Leu Ser Gly Asn Asn Leu Thr His Leu Pro Lys Gly Leu Leu Gly Ala
            180                 185                 190         
Gln Ala Lys Leu Glu Arg Leu Leu Leu His Ser Asn Arg Leu Val Ser
        195                 200                 205             
Leu Asp Ser Gly Leu Leu Asn Ser Leu Gly Ala Leu Thr Glu Leu Gln
    210                 215                 220                 
Phe His Arg Asn His Ile Arg Ser Ile Ala Pro Gly Ala Phe Asp Arg
225                 230                 235                 240 
Leu Pro Asn Leu Ser Ser Leu Thr Leu Ser Arg Asn His Leu Ala Phe
                245                 250                 255     
Leu Pro Ser Ala Leu Phe Leu His Ser His Asn Leu Thr Leu Leu Thr
            260                 265                 270         
Leu Phe Glu Asn Pro Leu Ala Glu Leu Pro Gly Val Leu Phe Gly Glu
        275                 280                 285             
Met Gly Gly Leu Gln Glu Leu Trp Leu Asn Arg Thr Gln Leu Arg Thr
    290                 295                 300                 
Leu Pro Ala Ala Ala Phe Arg Asn Leu Ser Arg Leu Arg Tyr Leu Gly
305                 310                 315                 320 
Val Thr Leu Ser Pro Arg Leu Ser Ala Leu Pro Gln Gly Ala Phe Gln
                325                 330                 335     
Gly Leu Gly Glu Leu Gln Val Leu Ala Leu His Ser Asn Gly Leu Thr
            340                 345                 350         
Ala Leu Pro Asp Gly Leu Leu Arg Gly Leu Gly Lys Leu Arg Gln Val
        355                 360                 365             
Ser Leu Arg Arg Asn Arg Leu Arg Ala Leu Pro Arg Ala Leu Phe Arg
    370                 375                 380                 
Asn Leu Ser Ser Leu Glu Ser Val Gln Leu Asp His Asn Gln Leu Glu
385                 390                 395                 400 
Thr Leu Pro Gly Asp Val Phe Gly Ala Leu Pro Arg Leu Thr Glu Val
                405                 410                 415     
Leu Leu Gly His Asn Ser Trp Arg Cys Asp Cys Gly Leu Gly Pro Phe
            420                 425                 430         
Leu Gly Trp Leu Arg Gln His Leu Gly Leu Val Gly Gly Glu Glu Pro
        435                 440                 445             
Pro Arg Cys Ala Gly Pro Gly Ala His Ala Gly Leu Pro Leu Trp Ala
    450                 455                 460                 
Leu Pro Gly Gly Asp Ala Glu Cys Pro Gly Pro Arg Gly Pro Pro Pro
465                 470                 475                 480 
Arg Pro Ala Ala Asp Ser Ser Ser Glu Ala Pro Val His Pro Ala Leu
                485                 490                 495     
Ala Pro Asn Ser Ser Glu Pro Trp Val Trp Ala Gln Pro Val Thr Thr
            500                 505                 510         
Gly Lys Gly Gln Asp His Ser Pro Phe Trp Gly Phe Tyr Phe Leu Leu
        515                 520                 525             
Leu Ala Val Gln Ala Met Ile Thr Val Ile Ile Val Phe Ala Met Ile
    530                 535                 540                 
Lys Ile Gly Gln Leu Phe Arg Lys Leu Ile Arg Glu Arg Ala Leu Gly
545                 550                 555                 560 


<210> 5590
<211> 444
<212> PRT
<213> Homo sapiens

<400> 5590
Met Lys Val Val Pro Ser Leu Leu Leu Ser Val Leu Leu Ala Gln Val
 1               5                  10                  15      
Trp Leu Val Pro Gly Leu Ala Pro Ser Pro Gln Ser Pro Glu Thr Pro
            20                  25                  30          
Ala Pro Gln Asn Gln Thr Ser Arg Val Val Gln Ala Pro Lys Glu Glu
        35                  40                  45              
Glu Glu Asp Glu Gln Glu Ala Ser Glu Glu Lys Ala Ser Glu Glu Glu
    50                  55                  60                  
Lys Ala Trp Leu Met Ala Ser Arg Gln Gln Leu Ala Lys Glu Thr Ser
65                  70                  75                  80  
Asn Phe Gly Phe Ser Leu Leu Arg Lys Ile Ser Met Arg His Asp Gly
                85                  90                  95      
Asn Met Val Phe Ser Pro Phe Gly Met Ser Leu Ala Met Thr Gly Leu
            100                 105                 110         
Met Leu Gly Ala Thr Gly Pro Thr Glu Thr Gln Ile Lys Arg Gly Leu
        115                 120                 125             
His Leu Gln Ala Leu Lys Pro Thr Lys Pro Gly Leu Leu Pro Ser Leu
    130                 135                 140                 
Phe Lys Gly Leu Arg Glu Thr Leu Ser Arg Asn Leu Glu Leu Gly Leu
145                 150                 155                 160 
Thr Gln Gly Ser Phe Ala Phe Ile His Lys Asp Phe Asp Val Lys Glu
                165                 170                 175     
Thr Phe Phe Asn Leu Ser Lys Arg Tyr Phe Asp Thr Glu Cys Val Pro
            180                 185                 190         
Met Asn Phe Arg Asn Ala Ser Gln Ala Lys Arg Leu Met Asn His Tyr
        195                 200                 205             
Ile Asn Lys Glu Thr Arg Gly Lys Ile Pro Lys Leu Phe Asp Glu Ile
    210                 215                 220                 
Asn Pro Glu Thr Lys Leu Ile Leu Val Asp Tyr Ile Leu Phe Lys Gly
225                 230                 235                 240 
Lys Trp Leu Thr Pro Phe Asp Pro Val Phe Thr Glu Val Asp Thr Phe
                245                 250                 255     
His Leu Asp Lys Tyr Lys Thr Ile Lys Val Pro Met Met Tyr Gly Ala
            260                 265                 270         
Gly Lys Phe Ala Ser Thr Phe Asp Lys Asn Phe Arg Cys His Val Leu
        275                 280                 285             
Lys Leu Pro Tyr Gln Gly Asn Ala Thr Met Leu Val Val Leu Met Glu
    290                 295                 300                 
Lys Met Gly Asp His Leu Ala Leu Glu Asp Tyr Leu Thr Thr Asp Leu
305                 310                 315                 320 
Val Glu Thr Trp Leu Arg Asn Met Lys Thr Arg Asn Met Glu Val Phe
                325                 330                 335     
Phe Pro Lys Phe Lys Leu Asp Gln Lys Tyr Glu Met His Glu Leu Leu
            340                 345                 350         
Arg Gln Met Gly Ile Arg Arg Ile Phe Ser Pro Phe Ala Asp Leu Ser
        355                 360                 365             
Glu Leu Ser Ala Thr Gly Arg Asn Leu Gln Val Ser Arg Val Leu Gln
    370                 375                 380                 
Arg Thr Val Ile Glu Val Asp Glu Arg Gly Thr Glu Ala Val Ala Gly
385                 390                 395                 400 
Ile Leu Ser Glu Ile Thr Ala Tyr Ser Met Pro Pro Val Ile Lys Val
                405                 410                 415     
Asp Arg Pro Phe His Phe Met Ile Tyr Glu Glu Thr Ser Gly Met Leu
            420                 425                 430         
Leu Phe Leu Gly Arg Val Val Asn Pro Thr Leu Leu
        435                 440                 


<210> 5591
<211> 513
<212> PRT
<213> Homo sapiens

<400> 5591
Met Thr Thr Gln Leu Pro Ala Tyr Val Ala Ile Leu Leu Phe Tyr Val
 1               5                  10                  15      
Ser Arg Ala Ser Cys Gln Asp Thr Phe Ile Ala Ala Val Tyr Glu His
            20                  25                  30          
Ala Ala Ile Leu Pro Asn Ala Thr Leu Thr Pro Val Ser Arg Glu Glu
        35                  40                  45              
Ala Leu Ala Leu Met Asn Arg Asn Leu Asp Ile Leu Glu Gly Ala Ile
    50                  55                  60                  
Thr Ser Ala Ala Asp Gln Gly Ala His Ile Ile Val Thr Pro Glu Asp
65                  70                  75                  80  
Ala Ile Tyr Gly Trp Asn Phe Asn Arg Asp Ser Leu Tyr Pro Tyr Leu
                85                  90                  95      
Glu Asp Ile Pro Asp Pro Glu Val Asn Trp Ile Pro Cys Asn Asn Arg
            100                 105                 110         
Asn Arg Phe Gly Gln Thr Pro Val Gln Glu Arg Leu Ser Cys Leu Ala
        115                 120                 125             
Lys Asn Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys Pro
    130                 135                 140                 
Cys Asp Thr Ser Asp Pro Gln Cys Pro Pro Asp Gly Arg Tyr Gln Tyr
145                 150                 155                 160 
Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Val Ala Arg Tyr
                165                 170                 175     
His Lys Gln Asn Leu Phe Met Gly Glu Asn Gln Phe Asn Val Pro Lys
            180                 185                 190         
Glu Pro Glu Ile Val Thr Phe Asn Thr Thr Phe Gly Ser Phe Gly Ile
        195                 200                 205             
Phe Thr Cys Phe Asp Ile Leu Phe His Asp Pro Ala Val Thr Leu Val
    210                 215                 220                 
Lys Asp Phe His Val Asp Thr Ile Val Phe Pro Thr Ala Trp Met Asn
225                 230                 235                 240 
Val Leu Pro His Leu Ser Ala Val Glu Phe His Ser Ala Trp Ala Met
                245                 250                 255     
Gly Met Arg Val Asn Phe Leu Ala Ser Asn Ile His Tyr Pro Ser Lys
            260                 265                 270         
Lys Met Thr Gly Ser Gly Ile Tyr Ala Pro Asn Ser Ser Arg Ala Phe
        275                 280                 285             
His Tyr Asp Met Lys Thr Glu Glu Gly Lys Leu Leu Leu Ser Gln Leu
    290                 295                 300                 
Asp Ser His Pro Ser His Ser Ala Val Val Asn Trp Thr Ser Tyr Ala
305                 310                 315                 320 
Ser Ser Ile Glu Ala Leu Ser Ser Gly Asn Lys Glu Phe Lys Gly Thr
                325                 330                 335     
Val Phe Phe Asp Glu Phe Thr Phe Val Lys Leu Thr Gly Val Ala Gly
            340                 345                 350         
Asn Tyr Thr Val Cys Gln Lys Asp Leu Cys Cys His Leu Ser Tyr Lys
        355                 360                 365             
Met Ser Glu Asn Ile Pro Asn Glu Val Tyr Ala Leu Gly Ala Phe Asp
    370                 375                 380                 
Gly Leu His Thr Val Glu Gly Arg Tyr Tyr Leu Gln Ile Cys Thr Leu
385                 390                 395                 400 
Leu Lys Cys Lys Thr Thr Asn Leu Asn Thr Cys Gly Asp Ser Ala Glu
                405                 410                 415     
Thr Ala Ser Thr Arg Phe Glu Met Phe Ser Leu Ser Gly Thr Phe Gly
            420                 425                 430         
Thr Gln Tyr Val Phe Pro Glu Val Leu Leu Ser Glu Asn Gln Leu Ala
        435                 440                 445             
Pro Gly Glu Phe Gln Val Ser Thr Asp Gly Arg Leu Phe Ser Leu Lys
    450                 455                 460                 
Pro Thr Ser Gly Pro Val Leu Thr Val Thr Leu Phe Gly Arg Leu Tyr
465                 470                 475                 480 
Glu Lys Asp Trp Ala Ser Asn Ala Ser Ser Gly Leu Thr Ala Gln Ala
                485                 490                 495     
Arg Ile Ile Met Leu Ile Val Ile Ala Pro Ile Val Cys Ser Leu Ser
            500                 505                 510         
Trp
    


<210> 5592
<211> 331
<212> PRT
<213> Homo sapiens

<400> 5592
Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala
 1               5                  10                  15      
Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly
            20                  25                  30          
Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala
        35                  40                  45              
Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser
    50                  55                  60                  
Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Leu Pro
65                  70                  75                  80  
Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu
                85                  90                  95      
Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu
            100                 105                 110         
Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser
        115                 120                 125             
Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile
    130                 135                 140                 
Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys
145                 150                 155                 160 
Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys
                165                 170                 175     
Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val
            180                 185                 190         
Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser
        195                 200                 205             
Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser
    210                 215                 220                 
Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys
225                 230                 235                 240 
Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn
                245                 250                 255     
Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr
            260                 265                 270         
Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp
        275                 280                 285             
Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys
    290                 295                 300                 
Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys
305                 310                 315                 320 
Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu
                325                 330     


<210> 5593
<211> 1997
<212> PRT
<213> Homo sapiens

<400> 5593
Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg
 1               5                  10                  15      
Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser
            20                  25                  30          
Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe
        35                  40                  45              
Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile
    50                  55                  60                  
Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr
65                  70                  75                  80  
Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val
                85                  90                  95      
Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu
            100                 105                 110         
Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp
        115                 120                 125             
Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys
    130                 135                 140                 
Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser
145                 150                 155                 160 
Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe
                165                 170                 175     
Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln
            180                 185                 190         
Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu
        195                 200                 205             
Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala
    210                 215                 220                 
Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro
225                 230                 235                 240 
Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val
                245                 250                 255     
Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp
            260                 265                 270         
Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met
        275                 280                 285             
Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp
    290                 295                 300                 
Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser
305                 310                 315                 320 
Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser
                325                 330                 335     
Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe
            340                 345                 350         
His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly
        355                 360                 365             
Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp
    370                 375                 380                 
Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile
385                 390                 395                 400 
Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp
                405                 410                 415     
Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met
            420                 425                 430         
Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn
        435                 440                 445             
Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys
    450                 455                 460                 
Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu
465                 470                 475                 480 
Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys
                485                 490                 495     
Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr
            500                 505                 510         
His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe
        515                 520                 525             
Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg
    530                 535                 540                 
Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly
545                 550                 555                 560 
Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu
                565                 570                 575     
Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln
            580                 585                 590         
Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu
        595                 600                 605             
Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg
    610                 615                 620                 
Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr
625                 630                 635                 640 
Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg
                645                 650                 655     
Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser
            660                 665                 670         
Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr
        675                 680                 685             
Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro
    690                 695                 700                 
Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp
705                 710                 715                 720 
Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp
                725                 730                 735     
Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu
            740                 745                 750         
Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser
        755                 760                 765             
Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His
    770                 775                 780                 
Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg
785                 790                 795                 800 
Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val
                805                 810                 815     
Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu
            820                 825                 830         
Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp
        835                 840                 845             
Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg
    850                 855                 860                 
Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly
865                 870                 875                 880 
Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys
                885                 890                 895     
Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu
            900                 905                 910         
Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly
        915                 920                 925             
Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu
    930                 935                 940                 
His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe
945                 950                 955                 960 
Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp
                965                 970                 975     
Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln
            980                 985                 990         
Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu Cys Pro Thr Trp Asp
        995                 1000                1005            
Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr Gly Glu Ala His Glu
    1010                1015                1020                
Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu Ile Tyr Asp Gln Asp
1025                1030                1035                1040
Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr Phe Ala Lys Pro Leu
                1045                1050                1055    
Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro Arg Phe Pro Pro Gln
            1060                1065                1070        
Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala Thr Ala Gly Asp Pro
        1075                1080                1085            
Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro Ala Gly Lys Ala Asp
    1090                1095                1100                
Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp Arg Gly Pro Ile Met
1105                1110                1115                1120
Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser Lys Tyr Arg Val Glu
                1125                1130                1135    
Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg Val Asn Leu Ala Gln
            1140                1145                1150        
Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala Gly Lys Gly Val Gln
        1155                1160                1165            
Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro Asn Phe Asn Thr Leu
    1170                1175                1180                
Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn Glu Leu Leu His Pro
1185                1190                1195                1200
Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala Phe Gly Arg Tyr Thr
                1205                1210                1215    
Leu Val Gly Ser His Ala Val Ser Ser Leu Arg Arg Phe Ile Tyr Arg
            1220                1225                1230        
Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr Thr Val Arg Leu Leu
        1235                1240                1245            
Arg Arg Cys Arg Val Leu Cys Asn Gly Gly Ser Ser Ser His Ser Thr
    1250                1255                1260                
Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys Leu
1265                1270                1275                1280
Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys Val
                1285                1290                1295    
Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly Thr
            1300                1305                1310        
Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp Trp
        1315                1320                1325            
Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu Arg
    1330                1335                1340                
Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val Asp
1345                1350                1355                1360
Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala Arg
                1365                1370                1375    
Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser Gly
            1380                1385                1390        
Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu Leu
        1395                1400                1405            
Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu Asp
    1410                1415                1420                
Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp Glu
1425                1430                1435                1440
Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly Ser
                1445                1450                1455    
Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu Ala
            1460                1465                1470        
Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn Asp
        1475                1480                1485            
Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp Leu
    1490                1495                1500                
His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile Arg
1505                1510                1515                1520
Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys Gln
                1525                1530                1535    
Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe Pro
            1540                1545                1550        
Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val Gly
        1555                1560                1565            
Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg Phe
    1570                1575                1580                
Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser Thr
1585                1590                1595                1600
His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile Leu
                1605                1610                1615    
Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly Pro
            1620                1625                1630        
Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser Glu
        1635                1640                1645            
Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val Ala
    1650                1655                1660                
Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys Arg
1665                1670                1675                1680
Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp Lys
                1685                1690                1695    
Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe Pro
            1700                1705                1710        
Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg Lys
        1715                1720                1725            
Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu Val
    1730                1735                1740                
Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp Ile
1745                1750                1755                1760
Phe Val Arg Gly Trp Leu Lys Gly Gln Gln Glu Asp Lys Gln Asp Thr
                1765                1770                1775    
Asp Val His Tyr His Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp Arg
            1780                1785                1790        
Tyr Leu Phe Pro Phe Asp Tyr Leu Ala Ala Glu Glu Lys Ile Val Ile
        1795                1800                1805            
Ser Lys Lys Glu Ser Met Phe Ser Trp Asp Glu Thr Glu Tyr Lys Ile
    1810                1815                1820                
Pro Ala Arg Leu Thr Leu Gln Ile Trp Asp Ala Asp His Phe Ser Ala
1825                1830                1835                1840
Asp Asp Phe Leu Gly Ala Ile Glu Leu Asp Leu Asn Arg Phe Pro Arg
                1845                1850                1855    
Gly Ala Lys Thr Ala Lys Gln Cys Thr Met Glu Met Ala Thr Gly Glu
            1860                1865                1870        
Val Asp Val Pro Leu Val Ser Ile Phe Lys Gln Lys Arg Val Lys Gly
        1875                1880                1885            
Trp Trp Pro Leu Leu Ala Arg Asn Glu Asn Asp Glu Phe Glu Leu Thr
    1890                1895                1900                
Gly Lys Val Glu Ala Glu Leu His Leu Leu Thr Ala Glu Glu Ala Glu
1905                1910                1915                1920
Lys Asn Pro Val Gly Leu Ala Arg Asn Glu Pro Asp Pro Leu Glu Lys
                1925                1930                1935    
Pro Asn Arg Pro Asp Thr Ser Phe Ile Trp Phe Leu Asn Pro Leu Lys
            1940                1945                1950        
Ser Ala Arg Tyr Phe Leu Trp His Thr Tyr Arg Trp Leu Leu Leu Lys
        1955                1960                1965            
Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Leu Phe Leu Tyr
    1970                1975                1980                
Ser Val Pro Gly Tyr Leu Val Lys Lys Ile Leu Gly Ala
1985                1990                1995        


<210> 5594
<211> 673
<212> PRT
<213> Homo sapiens

<400> 5594
Met Cys Ser Arg Val Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Ala
 1               5                  10                  15      
Leu Gly Pro Gly Val Gln Gly Cys Pro Ser Gly Cys Gln Cys Ser Gln
            20                  25                  30          
Pro Gln Thr Val Phe Cys Thr Ala Arg Gln Gly Thr Thr Val Pro Arg
        35                  40                  45              
Asp Val Pro Pro Asp Thr Val Gly Leu Tyr Val Phe Glu Asn Gly Ile
    50                  55                  60                  
Thr Met Leu Asp Ala Gly Ser Phe Ala Gly Leu Pro Gly Leu Gln Leu
65                  70                  75                  80  
Leu Asp Leu Ser Gln Asn Gln Ile Ala Ser Leu Pro Ser Gly Val Phe
                85                  90                  95      
Gln Pro Leu Ala Asn Leu Ser Asn Leu Asp Leu Thr Ala Asn Arg Leu
            100                 105                 110         
His Glu Ile Thr Asn Glu Thr Phe Arg Gly Leu Arg Arg Leu Glu Arg
        115                 120                 125             
Leu Tyr Leu Gly Lys Asn Arg Ile Arg His Ile Gln Pro Gly Ala Phe
    130                 135                 140                 
Asp Thr Leu Asp Arg Leu Leu Glu Leu Lys Leu Gln Asp Asn Glu Leu
145                 150                 155                 160 
Arg Ala Leu Pro Pro Leu Arg Leu Pro Arg Leu Leu Leu Leu Asp Leu
                165                 170                 175     
Ser His Asn Ser Leu Leu Ala Leu Glu Pro Gly Ile Leu Asp Thr Ala
            180                 185                 190         
Asn Val Glu Ala Leu Arg Leu Ala Gly Leu Gly Leu Gln Gln Leu Asp
        195                 200                 205             
Glu Gly Leu Phe Ser Arg Leu Arg Asn Leu His Asp Leu Asp Val Ser
    210                 215                 220                 
Asp Asn Gln Leu Glu Arg Val Pro Pro Val Ile Arg Gly Leu Arg Gly
225                 230                 235                 240 
Leu Thr Arg Leu Arg Leu Ala Gly Asn Thr Arg Ile Ala Gln Leu Arg
                245                 250                 255     
Pro Glu Asp Leu Ala Gly Leu Ala Ala Leu Gln Glu Leu Asp Val Ser
            260                 265                 270         
Asn Leu Ser Leu Gln Ala Leu Pro Gly Asp Leu Ser Gly Leu Phe Pro
        275                 280                 285             
Arg Leu Arg Leu Leu Ala Ala Ala Arg Asn Pro Phe Asn Cys Val Cys
    290                 295                 300                 
Pro Leu Ser Trp Phe Gly Pro Trp Val Arg Glu Ser His Val Thr Leu
305                 310                 315                 320 
Ala Ser Pro Glu Glu Thr Arg Cys His Phe Pro Pro Lys Asn Ala Gly
                325                 330                 335     
Arg Leu Leu Leu Glu Leu Asp Tyr Ala Asp Phe Gly Cys Pro Ala Thr
            340                 345                 350         
Thr Thr Thr Ala Thr Val Pro Thr Thr Arg Pro Val Val Arg Glu Pro
        355                 360                 365             
Thr Ala Leu Ser Ser Ser Leu Ala Pro Thr Trp Leu Ser Pro Thr Ala
    370                 375                 380                 
Pro Ala Thr Glu Ala Pro Ser Pro Pro Ser Thr Ala Pro Pro Thr Val
385                 390                 395                 400 
Gly Pro Val Pro Gln Pro Gln Asp Cys Pro Pro Ser Thr Cys Leu Asn
                405                 410                 415     
Gly Gly Thr Cys His Leu Gly Thr Arg His His Leu Ala Cys Leu Cys
            420                 425                 430         
Pro Glu Gly Phe Thr Gly Leu Tyr Cys Glu Ser Gln Met Gly Gln Gly
        435                 440                 445             
Thr Arg Pro Ser Pro Thr Pro Val Thr Pro Arg Pro Pro Arg Ser Leu
    450                 455                 460                 
Thr Leu Gly Ile Glu Pro Val Ser Pro Thr Ser Leu Arg Val Gly Leu
465                 470                 475                 480 
Gln Arg Tyr Leu Gln Gly Ser Ser Val Gln Leu Arg Ser Leu Arg Leu
                485                 490                 495     
Thr Tyr Arg Asn Leu Ser Gly Pro Asp Lys Arg Leu Val Thr Leu Arg
            500                 505                 510         
Leu Pro Ala Ser Leu Ala Glu Tyr Thr Val Thr Gln Leu Arg Pro Asn
        515                 520                 525             
Ala Thr Tyr Ser Val Cys Val Met Pro Leu Gly Pro Gly Arg Val Pro
    530                 535                 540                 
Glu Gly Glu Glu Ala Cys Gly Glu Ala His Thr Pro Pro Ala Val His
545                 550                 555                 560 
Ser Asn His Ala Pro Val Thr Gln Ala Arg Glu Gly Asn Leu Pro Leu
                565                 570                 575     
Leu Ile Ala Pro Ala Leu Ala Ala Val Leu Leu Ala Ala Leu Ala Ala
            580                 585                 590         
Val Gly Ala Ala Tyr Cys Val Arg Arg Gly Arg Ala Met Ala Ala Ala
        595                 600                 605             
Ala Gln Asp Lys Gly Gln Val Gly Pro Gly Ala Gly Pro Leu Glu Leu
    610                 615                 620                 
Glu Gly Val Lys Val Pro Leu Glu Pro Gly Pro Lys Ala Thr Glu Gly
625                 630                 635                 640 
Gly Gly Glu Ala Leu Pro Ser Gly Ser Glu Cys Glu Val Pro Leu Met
                645                 650                 655     
Gly Phe Pro Gly Pro Gly Leu Gln Ser Pro Leu His Ala Lys Pro Tyr
            660                 665                 670         
Ile
    


<210> 5595
<211> 728
<212> PRT
<213> Homo sapiens

<400> 5595
Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys
 1               5                  10                  15      
Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln
            20                  25                  30          
Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp
        35                  40                  45              
Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His
    50                  55                  60                  
Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val
65                  70                  75                  80  
Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr
                85                  90                  95      
Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser
            100                 105                 110         
Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe
        115                 120                 125             
Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys
    130                 135                 140                 
Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr
145                 150                 155                 160 
Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr
                165                 170                 175     
Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln
            180                 185                 190         
Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys
        195                 200                 205             
Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val
    210                 215                 220                 
Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val
225                 230                 235                 240 
Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu
                245                 250                 255     
Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser
            260                 265                 270         
His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg
        275                 280                 285             
Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu
    290                 295                 300                 
Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe
305                 310                 315                 320 
Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu
                325                 330                 335     
Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp
            340                 345                 350         
Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg
        355                 360                 365             
Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn
    370                 375                 380                 
Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro
385                 390                 395                 400 
Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala
                405                 410                 415     
Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys
            420                 425                 430         
Leu Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys
        435                 440                 445             
Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln
    450                 455                 460                 
Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp
465                 470                 475                 480 
Phe Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu Thr Ala Ala
                485                 490                 495     
His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser
            500                 505                 510         
Lys Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys
        515                 520                 525             
Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp
    530                 535                 540                 
Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln
545                 550                 555                 560 
Glu Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg
                565                 570                 575     
Leu Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala Gly
            580                 585                 590         
Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser
        595                 600                 605             
Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val
    610                 615                 620                 
Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn
625                 630                 635                 640 
Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly
                645                 650                 655     
Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Phe Asp
            660                 665                 670         
Asp Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly
        675                 680                 685             
Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val
    690                 695                 700                 
Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Leu Pro Gln Ser
705                 710                 715                 720 
Val Val Glu Pro Gln Val Glu Arg
                725             


<210> 5596
<211> 809
<212> PRT
<213> Homo sapiens

<400> 5596
Ser Gln Pro His Arg Ile Lys Glu Gly Arg Glu Gly Ala Asp Leu Phe
 1               5                  10                  15      
Gly Arg Lys Thr Asp Phe Val Val Arg Phe Leu Gly Val Gln Glu Gln
            20                  25                  30          
Val Lys Gly Glu Arg Glu Glu Arg Gly Lys Ala Arg Gly Arg Glu Gly
        35                  40                  45              
Glu Arg Gly Ser Val Ala Gly Arg Gly Arg Arg Asp Leu Asn Gly Glu
    50                  55                  60                  
Cys Gln Pro Ile Pro Glu Thr His Arg Asp Leu Arg Thr Lys Ile Arg
65                  70                  75                  80  
His His Gly His His Thr Gly His Glu Leu Thr Gly Lys Ser Ser Trp
                85                  90                  95      
Glu Asp Gln Gly Arg Ala Ala Gly Ser Thr Gln Gly Arg Lys Met Arg
            100                 105                 110         
Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys Ala Ser
        115                 120                 125             
Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln Ser Pro
    130                 135                 140                 
Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp Asn Ile
145                 150                 155                 160 
Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His Phe Asn
                165                 170                 175     
Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val Glu Thr
            180                 185                 190         
Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr Asp Thr
        195                 200                 205             
Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser Phe Met
    210                 215                 220                 
Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly
225                 230                 235                 240 
Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys Glu Arg
                245                 250                 255     
Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr Ile Gly
            260                 265                 270         
Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr Asp Asn
        275                 280                 285             
Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln Arg Thr
    290                 295                 300                 
Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys Ser Ser
305                 310                 315                 320 
Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val Asn Leu
                325                 330                 335     
Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val Pro Cys
            340                 345                 350         
Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu Gly Pro
        355                 360                 365             
Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser His Ser
    370                 375                 380                 
Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg Gly Trp
385                 390                 395                 400 
Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu Gln Pro
                405                 410                 415     
Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe Phe Lys
            420                 425                 430         
Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu Lys Asp
        435                 440                 445             
Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp Gly Thr
    450                 455                 460                 
Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg Ala Pro
465                 470                 475                 480 
Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn Asn Leu
                485                 490                 495     
Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro Tyr Tyr
            500                 505                 510         
Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala Gln Gly
        515                 520                 525             
Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys Leu Pro
    530                 535                 540                 
Val Cys Gly Leu Pro Lys Phe Ser Arg Lys Leu Met Ala Arg Ile Phe
545                 550                 555                 560 
Asn Gly Arg Pro Ala Gln Lys Gly Thr Thr Pro Trp Ile Ala Met Leu
                565                 570                 575     
Ser His Leu Asn Gly Gln Pro Phe Cys Gly Gly Ser Leu Leu Gly Ser
            580                 585                 590         
Ser Trp Ile Val Thr Ala Ala His Cys Leu His Gln Ser Leu Asp Pro
        595                 600                 605             
Glu Asp Pro Thr Leu Arg Asp Ser Asp Leu Leu Ser Pro Ser Asp Phe
    610                 615                 620                 
Lys Ile Ile Leu Gly Lys His Trp Arg Leu Arg Ser Asp Glu Asn Glu
625                 630                 635                 640 
Gln His Leu Gly Val Lys His Thr Thr Leu His Pro Gln Tyr Asp Pro
                645                 650                 655     
Asn Thr Phe Glu Asn Asp Val Ala Leu Val Glu Leu Leu Glu Ser Pro
            660                 665                 670         
Val Leu Asn Ala Phe Val Met Pro Ile Cys Leu Pro Glu Gly Pro Gln
        675                 680                 685             
Gln Glu Gly Ala Met Val Ile Val Ser Gly Trp Gly Lys Gln Phe Leu
    690                 695                 700                 
Gln Arg Phe Pro Glu Thr Leu Met Glu Ile Glu Ile Pro Ile Val Asp
705                 710                 715                 720 
His Ser Thr Cys Gln Lys Ala Tyr Ala Pro Leu Lys Lys Lys Val Thr
                725                 730                 735     
Arg Asp Met Ile Cys Ala Gly Glu Lys Glu Gly Gly Lys Asp Ala Cys
            740                 745                 750         
Ala Gly Asp Ser Gly Gly Pro Met Val Thr Leu Asn Arg Glu Arg Gly
        755                 760                 765             
Gln Trp Tyr Leu Val Gly Thr Val Ser Trp Gly Asp Asp Cys Gly Lys
    770                 775                 780                 
Lys Asp Arg Tyr Gly Val Tyr Ser Tyr Ile His His Asn Lys Asp Trp
785                 790                 795                 800 
Ile Gln Arg Val Thr Gly Val Arg Asn
                805                 


<210> 5597
<211> 465
<212> PRT
<213> Homo sapiens

<400> 5597
Met Lys Pro Thr Gly Thr Asp Pro Arg Ile Leu Ser Ile Ala Ala Glu
 1               5                  10                  15      
Val Ala Lys Ser Pro Glu Gln Asn Val Pro Val Ile Leu Leu Lys Leu
            20                  25                  30          
Lys Glu Ile Ile Asn Ile Thr Pro Leu Gly Ser Ser Glu Leu Lys Lys
        35                  40                  45              
Ile Lys Gln Asp Ile Tyr Cys Tyr Asp Leu Ile Gln Tyr Cys Leu Leu
    50                  55                  60                  
Val Leu Ser Gln Asp Tyr Ser Arg Ile Gln Gly Gly Trp Thr Thr Ile
65                  70                  75                  80  
Ser Gln Leu Thr Gln Ile Leu Ser His Cys Cys Val Gly Leu Glu Pro
                85                  90                  95      
Gly Glu Asp Ala Glu Glu Phe Tyr Asn Glu Leu Leu Pro Ser Ala Ala
            100                 105                 110         
Glu Asn Phe Leu Val Leu Gly Arg Gln Leu Gln Thr Cys Phe Ile Asn
        115                 120                 125             
Ala Ala Lys Ala Glu Glu Lys Asp Glu Leu Leu His Phe Phe Gln Ile
    130                 135                 140                 
Val Thr Asp Ser Leu Phe Trp Leu Leu Gly Gly His Val Glu Leu Ile
145                 150                 155                 160 
Gln Asn Val Leu Gln Ser Asp His Phe Leu His Leu Leu Gln Ala Asp
                165                 170                 175     
Asn Val Gln Ile Gly Ser Ala Val Met Met Met Leu Gln Asn Ile Leu
            180                 185                 190         
Gln Ile Asn Arg Ser Lys Arg Ser Lys Met Leu Leu Glu Ile Asn Arg
        195                 200                 205             
Gln Lys Glu Glu Glu Asp Leu Lys Leu Gln Leu Gln Leu Gln Arg Gln
    210                 215                 220                 
Arg Ala Met Arg Leu Ser Arg Glu Leu Gln Leu Ser Met Leu Glu Ile
225                 230                 235                 240 
Val His Pro Gly Gln Val Glu Lys His Tyr Arg Glu Met Glu Glu Lys
                245                 250                 255     
Ser Ala Leu Ile Ile Gln Lys His Trp Arg Gly Tyr Arg Glu Arg Lys
            260                 265                 270         
Asn Phe His Gln Gln Arg Gln Ser Leu Ile Glu Tyr Lys Ala Ala Val
        275                 280                 285             
Thr Leu Gln Arg Ala Ala Leu Lys Phe Leu Ala Lys Tyr Arg Lys Lys
    290                 295                 300                 
Lys Lys Leu Phe Ala Pro Trp Arg Gly Leu Gln Glu Leu Thr Asp Ala
305                 310                 315                 320 
Arg Arg Val Glu Leu Lys Lys Arg Val Asp Asp Tyr Val Arg Arg His
                325                 330                 335     
Leu Gly Ser Pro Met Ser Asp Val Val Ser Arg Glu Leu His Ala Gln
            340                 345                 350         
Ala Gln Glu Arg Leu Gln His Tyr Phe Met Gly Arg Ala Leu Glu Glu
        355                 360                 365             
Arg Ala Gln Gln His Arg Glu Ala Leu Ile Ala Gln Ile Ser Thr Asn
    370                 375                 380                 
Val Glu Gln Leu Met Lys Ala Pro Ser Leu Lys Glu Ala Glu Gly Lys
385                 390                 395                 400 
Glu Pro Glu Leu Phe Leu Ser Arg Ser Arg Pro Val Ala Ala Lys Ala
                405                 410                 415     
Lys Gln Ala His Leu Thr Thr Leu Lys His Ile Gln Ala Pro Trp Trp
            420                 425                 430         
Lys Lys Leu Gly Glu Glu Ser Gly Asp Glu Ile Asp Val Pro Lys Asp
        435                 440                 445             
Glu Leu Ser Ile Glu Leu Glu Asn Leu Phe Ile Gly Gly Thr Lys Pro
    450                 455                 460                 
Pro
465 


<210> 5598
<211> 5703
<212> PRT
<213> Homo sapiens

<400> 5598
Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala
 1               5                  10                  15      
Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val Glu Pro Ser
            20                  25                  30          
Trp Gly Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser
        35                  40                  45              
Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser
    50                  55                  60                  
Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp
65                  70                  75                  80  
Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro
                85                  90                  95      
Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu
            100                 105                 110         
Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val
        115                 120                 125             
Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu Glu Ala Ser
    130                 135                 140                 
Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser
145                 150                 155                 160 
Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser
                165                 170                 175     
Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu
            180                 185                 190         
Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly
        195                 200                 205             
Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala
    210                 215                 220                 
Arg Leu Thr Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro
225                 230                 235                 240 
Thr Glu Gln Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr
                245                 250                 255     
Asp Glu Glu Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala
            260                 265                 270         
Glu Cys His Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala
        275                 280                 285             
Gln Asp Leu Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu
    290                 295                 300                 
Tyr Ser Arg Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg
305                 310                 315                 320 
Cys Pro Glu Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln
                325                 330                 335     
Glu Cys Gly Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala
            340                 345                 350         
Gln Leu Cys Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly
        355                 360                 365             
Ser Thr Val Leu Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly
    370                 375                 380                 
Gln Cys Pro Cys Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser
385                 390                 395                 400 
Phe Asn Thr Thr Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln
                405                 410                 415     
Cys Gln Asp Leu Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala
            420                 425                 430         
His Ile Ser Thr Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys
        435                 440                 445             
Ser Tyr Val Leu Ser Lys Lys Cys Ala Asp Ser Ser Phe Thr Val Leu
    450                 455                 460                 
Ala Glu Leu Arg Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys
465                 470                 475                 480 
Ala Val Thr Leu Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln
                485                 490                 495     
Ala Asp Gly Gly Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu
            500                 505                 510         
Ser Ala Ala Asn Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val
        515                 520                 525             
Val Gln Thr Gly Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu
    530                 535                 540                 
Met Gln Val Phe Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys
545                 550                 555                 560 
Gly Leu Cys Gly Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala
                565                 570                 575     
Leu Ser Gly Val Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp
            580                 585                 590         
Lys Ala Gln Ala Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro
        595                 600                 605             
Cys Ser Leu Ser Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser
    610                 615                 620                 
Arg Leu Thr Asp Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile
625                 630                 635                 640 
Asn Pro Lys Pro Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys
                645                 650                 655     
Glu Arg Ser Glu Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His
            660                 665                 670         
Ala Cys Ala Ala Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val
        675                 680                 685             
Cys Thr Lys Tyr Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr
    690                 695                 700                 
Val Val Asp Ala Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp
705                 710                 715                 720 
Val Thr Cys Ser Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro
                725                 730                 735     
Ala Gly Thr Phe Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu
            740                 745                 750         
Cys Pro Cys Tyr Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val
        755                 760                 765             
His Asp Glu Gly Ala Val Cys Ser Cys Thr Gly Gly Lys Leu Ser Cys
    770                 775                 780                 
Leu Gly Ala Ser Leu Gln Lys Ser Thr Gly Cys Ala Ala Pro Met Val
785                 790                 795                 800 
Tyr Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro Gly Ala Glu Cys
                805                 810                 815     
Leu Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe Ser Thr His Cys
            820                 825                 830         
Val Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser Asp Gly Ser Gly
        835                 840                 845             
Gly Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His Asn Glu Ala Thr
    850                 855                 860                 
Tyr Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn Thr Cys Thr Cys
865                 870                 875                 880 
Arg Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys Leu Gly Thr Cys
                885                 890                 895     
Val Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp Gly Asp Arg Tyr
            900                 905                 910         
Ser Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln Asp Tyr Cys Gly
        915                 920                 925             
Asp Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr Glu Asn Ile Pro
    930                 935                 940                 
Cys Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile Lys Leu Phe Val
945                 950                 955                 960 
Glu Ser Tyr Glu Leu Ile Leu Gln Glu Gly Thr Phe Lys Ala Val Ala
                965                 970                 975     
Arg Gly Pro Gly Gly Asp Pro Pro Tyr Lys Ile Arg Tyr Met Gly Ile
            980                 985                 990         
Phe Leu Val Ile Glu Thr His Gly Met Ala Val Ser Trp Asp Arg Lys
        995                 1000                1005            
Thr Ser Val Phe Ile Arg Leu His Gln Asp Tyr Lys Gly Arg Val Cys
    1010                1015                1020                
Gly Leu Cys Gly Asn Phe Asp Asp Asn Ala Ile Asn Asp Phe Ala Thr
1025                1030                1035                1040
Arg Ser Arg Ser Val Val Gly Asp Ala Leu Glu Phe Gly Asn Ser Trp
                1045                1050                1055    
Lys Leu Ser Pro Ser Cys Pro Asp Ala Leu Ala Pro Lys Asp Pro Cys
            1060                1065                1070        
Thr Ala Asn Pro Phe Arg Lys Ser Trp Ala Gln Lys Gln Cys Ser Ile
        1075                1080                1085            
Leu His Gly Pro Thr Phe Ala Ala Cys Arg Ser Gln Val Asp Ser Thr
    1090                1095                1100                
Lys Tyr Tyr Glu Ala Cys Val Asn Asp Ala Cys Ala Cys Asp Ser Gly
1105                1110                1115                1120
Gly Asp Cys Glu Cys Phe Cys Thr Ala Val Ala Ala Tyr Ala Gln Ala
                1125                1130                1135    
Cys His Asp Ala Gly Leu Cys Val Ser Trp Arg Thr Pro Asp Thr Cys
            1140                1145                1150        
Pro Leu Phe Cys Asp Phe Tyr Asn Pro His Gly Gly Cys Glu Trp His
        1155                1160                1165            
Tyr Gln Pro Cys Gly Ala Pro Cys Leu Lys Thr Cys Arg Asn Pro Ser
    1170                1175                1180                
Gly His Cys Leu Val Asp Leu Pro Gly Leu Glu Gly Cys Tyr Pro Lys
1185                1190                1195                1200
Cys Pro Pro Ser Gln Pro Phe Phe Asn Glu Asp Gln Met Lys Cys Val
                1205                1210                1215    
Ala Gln Cys Gly Cys Tyr Asp Lys Asp Gly Asn Tyr Tyr Asp Val Gly
            1220                1225                1230        
Ala Arg Val Pro Thr Ala Glu Asn Cys Gln Ser Cys Asn Cys Thr Pro
        1235                1240                1245            
Ser Gly Ile Gln Cys Ala His Ser Leu Glu Ala Cys Thr Cys Thr Tyr
    1250                1255                1260                
Glu Asp Arg Thr Tyr Ser Tyr Gln Asp Val Ile Tyr Asn Thr Thr Asp
1265                1270                1275                1280
Gly Leu Gly Ala Cys Leu Ile Ala Ile Cys Gly Ser Asn Gly Thr Ile
                1285                1290                1295    
Ile Arg Lys Ala Val Ala Cys Pro Gly Thr Pro Ala Thr Thr Pro Phe
            1300                1305                1310        
Thr Phe Thr Thr Ala Trp Val Pro His Ser Thr Thr Ser Pro Ala Leu
        1315                1320                1325            
Pro Val Ser Thr Val Cys Val Arg Glu Val Cys Arg Trp Ser Ser Trp
    1330                1335                1340                
Tyr Asn Gly His Arg Pro Glu Pro Gly Leu Gly Gly Gly Asp Phe Glu
1345                1350                1355                1360
Thr Phe Glu Asn Leu Arg Gln Arg Gly Tyr Gln Val Cys Pro Val Leu
                1365                1370                1375    
Ala Asp Ile Glu Cys Arg Ala Ala Gln Leu Pro Asp Met Pro Leu Glu
            1380                1385                1390        
Glu Leu Gly Gln Gln Val Asp Cys Asp Arg Met Arg Gly Leu Met Cys
        1395                1400                1405            
Ala Asn Ser Gln Gln Ser Pro Pro Leu Cys His Asp Tyr Glu Leu Arg
    1410                1415                1420                
Val Leu Cys Cys Glu Tyr Val Pro Cys Gly Pro Ser Pro Ala Pro Gly
1425                1430                1435                1440
Thr Ser Pro Gln Pro Ser Leu Ser Ala Ser Thr Glu Pro Ala Val Pro
                1445                1450                1455    
Thr Pro Thr Gln Thr Thr Ala Thr Glu Lys Thr Thr Leu Trp Val Thr
            1460                1465                1470        
Pro Ser Ile Arg Ser Thr Ala Ala Leu Thr Ser Gln Thr Gly Ser Ser
        1475                1480                1485            
Ser Gly Pro Val Thr Val Thr Pro Ser Ala Pro Gly Thr Thr Thr Cys
    1490                1495                1500                
Gln Pro Arg Cys Gln Trp Thr Glu Trp Phe Asp Glu Asp Tyr Pro Lys
1505                1510                1515                1520
Ser Glu Gln Leu Gly Gly Asp Val Glu Ser Tyr Asp Lys Ile Arg Ala
                1525                1530                1535    
Ala Gly Gly His Leu Cys Gln Gln Pro Lys Asp Ile Glu Cys Gln Ala
            1540                1545                1550        
Glu Ser Phe Pro Asn Trp Thr Leu Ala Gln Val Gly Gln Lys Val His
        1555                1560                1565            
Cys Asp Val His Phe Gly Leu Val Cys Arg Asn Trp Glu Gln Glu Gly
    1570                1575                1580                
Val Phe Lys Met Cys Tyr Asn Tyr Arg Ile Arg Val Leu Cys Cys Ser
1585                1590                1595                1600
Asp Asp His Cys Arg Gly Arg Ala Thr Thr Pro Pro Pro Thr Thr Glu
                1605                1610                1615    
Leu Glu Thr Ala Thr Thr Thr Thr Thr Gln Ala Leu Phe Ser Thr Pro
            1620                1625                1630        
Gln Pro Thr Ser Ser Pro Gly Leu Thr Arg Ala Pro Pro Ala Ser Thr
        1635                1640                1645            
Thr Ala Val Pro Thr Leu Ser Glu Gly Leu Thr Ser Pro Arg Tyr Thr
    1650                1655                1660                
Ser Thr Leu Gly Thr Ala Thr Thr Gly Gly Pro Arg Gln Ser Ala Gly
1665                1670                1675                1680
Ser Thr Glu Pro Thr Val Pro Gly Val Ala Thr Ser Thr Leu Pro Thr
                1685                1690                1695    
Arg Ser Ala Leu Pro Gly Thr Thr Gly Ser Leu Gly Thr Trp Arg Pro
            1700                1705                1710        
Ser Gln Pro Pro Thr Leu Ala Pro Thr Thr Met Ala Thr Ser Arg Ala
        1715                1720                1725            
Arg Pro Thr Gly Thr Ala Ser Thr Ala Ser Lys Glu Pro Leu Thr Thr
    1730                1735                1740                
Ser Leu Ala Pro Thr Leu Thr Ser Glu Leu Ser Thr Ser Gln Ala Glu
1745                1750                1755                1760
Thr Ser Thr Pro Arg Thr Glu Thr Thr Met Ser Pro Leu Thr Asn Thr
                1765                1770                1775    
Thr Thr Ser Gln Gly Thr Thr Arg Cys Gln Pro Lys Cys Glu Trp Thr
            1780                1785                1790        
Glu Trp Phe Asp Val Asp Phe Pro Thr Ser Gly Val Ala Ser Gly Asp
        1795                1800                1805            
Met Glu Thr Phe Glu Asn Ile Arg Ala Ala Gly Gly Lys Met Cys Trp
    1810                1815                1820                
Ala Pro Lys Ser Ile Glu Cys Arg Ala Glu Asn Tyr Pro Glu Val Ser
1825                1830                1835                1840
Ile Asp Gln Val Gly Gln Val Leu Thr Cys Ser Leu Glu Thr Gly Leu
                1845                1850                1855    
Thr Cys Lys Asn Glu Asp Gln Thr Gly Arg Phe Asn Met Cys Phe Asn
            1860                1865                1870        
Tyr Asn Val Arg Val Leu Cys Cys Asp Asp Tyr Ser His Cys Pro Ser
        1875                1880                1885            
Thr Leu Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr
    1890                1895                1900                
Thr Trp Ile Leu Thr Lys Pro Thr Thr Thr Ala Thr Thr Thr Ala Ser
1905                1910                1915                1920
Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala Thr Ala Gly Thr
                1925                1930                1935    
Pro His Val Ser Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys
            1940                1945                1950        
Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu
        1955                1960                1965            
Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro
    1970                1975                1980                
Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr
1985                1990                1995                2000
Pro Met Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr
                2005                2010                2015    
Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Thr Thr Gly Ala
            2020                2025                2030        
Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr
        2035                2040                2045            
Thr Lys Val Leu Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser
    2050                2055                2060                
Ser Ser Pro Gly Arg Ala Arg Thr Leu Pro Val Trp Ile Ser Thr Thr
2065                2070                2075                2080
Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser Ile Pro
                2085                2090                2095    
Gly Thr Thr His Thr Pro Thr Val Leu Thr Thr Thr Thr Thr Thr Val
            2100                2105                2110        
Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly
        2115                2120                2125            
Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly
    2130                2135                2140                
Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro
2145                2150                2155                2160
Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser Ser Thr Val
                2165                2170                2175    
Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro Pro Val Pro Asn
            2180                2185                2190        
Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser Pro Ser Ser Pro His
        2195                2200                2205            
Thr Val Cys Thr Ala Trp Thr Ser Ala Thr Ser Gly Ile Leu Gly Thr
    2210                2215                2220                
Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His Thr Pro Ala Ala
2225                2230                2235                2240
Thr Thr Gly Thr Thr Gln His Ser Thr Pro Ala Leu Ser Ser Pro His
                2245                2250                2255    
Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr Thr
            2260                2265                2270        
Pro Gly His Thr Thr Ala Thr Ser Arg Thr Thr Ala Thr Ala Thr Pro
        2275                2280                2285            
Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Gln Pro Thr Ser Ala
    2290                2295                2300                
Pro Ile Thr Thr Val Val Thr Met Gly Cys Glu Pro Gln Cys Ala Trp
2305                2310                2315                2320
Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly Gly
                2325                2330                2335    
Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala Val Cys
            2340                2345                2350        
Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala Gln Pro Gly Val
        2355                2360                2365            
Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser Leu Asp Phe Gly
    2370                2375                2380                
Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe Lys Met Cys Phe
2385                2390                2395                2400
Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly His Cys Pro Ser
                2405                2410                2415    
Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr
            2420                2425                2430        
Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Glu Ser
        2435                2440                2445            
Thr Gly Ser Thr Ala Thr Pro Thr Ser Thr Leu Arg Thr Ala Pro Pro
    2450                2455                2460                
Pro Lys Val Leu Thr Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser
2465                2470                2475                2480
Lys Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala
                2485                2490                2495    
Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Val Thr Pro Ile
            2500                2505                2510        
Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr
        2515                2520                2525            
Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu
    2530                2535                2540                
Thr Ala His Thr Ser Thr Val Leu Thr Ala Thr Ala Thr Thr Thr Gly
2545                2550                2555                2560
Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His
                2565                2570                2575    
Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro
            2580                2585                2590        
Ser Ser Ser Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr
        2595                2600                2605            
Thr Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser Ile
    2610                2615                2620                
Pro Gly Thr Thr His Thr Ala Thr Val Leu Thr Thr Thr Thr Thr Thr
2625                2630                2635                2640
Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser
                2645                2650                2655    
Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr
            2660                2665                2670        
Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Arg Pro Ile Pro
        2675                2680                2685            
Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser Ser Thr
    2690                2695                2700                
Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro Pro Val Pro
2705                2710                2715                2720
Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu Ser Pro Ser Ser Pro
                2725                2730                2735    
His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr Ser Gly Thr Leu Gly
            2740                2745                2750        
Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr Ser His Thr Pro Ala
        2755                2760                2765            
Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro Ala Leu Ser Ser Pro
    2770                2775                2780                
His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr
2785                2790                2795                2800
Thr Pro Gly His Thr Thr Ala Thr Ser Arg Thr Thr Ala Thr Ala Thr
                2805                2810                2815    
Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Ser Pro Thr Ser
            2820                2825                2830        
Ala Pro Ile Thr Thr Val Val Thr Met Gly Cys Glu Pro Gln Cys Ala
        2835                2840                2845            
Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly
    2850                2855                2860                
Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala Val
2865                2870                2875                2880
Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala Gln Pro Gly
                2885                2890                2895    
Val Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser Leu Asp Phe
            2900                2905                2910        
Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe Lys Met Cys
        2915                2920                2925            
Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly His Cys Pro
    2930                2935                2940                
Ser Thr Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly
2945                2950                2955                2960
Thr Thr Trp Ile Leu Thr Glu Gln Thr Thr Ala Ala Thr Thr Thr Ala
                2965                2970                2975    
Thr Thr Gly Ser Thr Ala Ile Pro Ser Ser Thr Pro Gly Thr Ala Pro
            2980                2985                2990        
Pro Pro Lys Val Leu Thr Ser Gln Ala Thr Thr Pro Thr Ala Thr Ser
        2995                3000                3005            
Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro
    3010                3015                3020                
Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser Phe Thr Pro
3025                3030                3035                3040
Ile Pro Ser Ser Thr Leu Gly Thr Thr Gly Thr Ser Gln Asn Arg Pro
                3045                3050                3055    
Pro His Pro Met Ala Thr Met Ser Thr Ile His Pro Ser Ser Thr Pro
            3060                3065                3070        
Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Lys Ala Thr Thr Thr
        3075                3080                3085            
Arg Ala Thr Ser Ser Met Ser Thr Pro Ser Ser Thr Pro Gly Thr Thr
    3090                3095                3100                
Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr Thr Thr Ala Ala Leu
3105                3110                3115                3120
Pro His Gly Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr
                3125                3130                3135    
Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr Gly Ser Thr Ala
            3140                3145                3150        
Thr Ala Ser Ser Thr Arg Ala Thr Ala Gly Thr Leu Lys Val Leu Thr
        3155                3160                3165            
Ser Thr Ala Thr Thr Pro Thr Val Ile Ser Ser Arg Ala Thr Pro Ser
    3170                3175                3180                
Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala
3185                3190                3195                3200
Thr Thr Pro Thr Ala Thr Ser Val Thr Ala Ile Pro Ser Ser Ser Leu
                3205                3210                3215    
Gly Thr Ala Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr
            3220                3225                3230        
Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His Thr Ser
        3235                3240                3245            
Thr Val Leu Thr Thr Thr Ala Thr Thr Thr Arg Thr Gly Ser Val Ala
    3250                3255                3260                
Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr
3265                3270                3275                3280
Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr
                3285                3290                3295    
Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr
            3300                3305                3310        
Arg Gly Ser Thr Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His Thr
        3315                3320                3325            
Ala Thr Val Leu Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met
    3330                3335                3340                
Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu
3345                3350                3355                3360
Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro
                3365                3370                3375    
Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr
            3380                3385                3390        
Ala Thr Thr Pro Ala Ala Thr Ser Ser Thr Val Thr Pro Ser Ser Ala
        3395                3400                3405            
Leu Gly Thr Thr His Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr
    3410                3415                3420                
His Gly Arg Ser Leu Pro Pro Ser Ser Pro His Thr Val Pro Thr Ala
3425                3430                3435                3440
Trp Thr Ser Ala Thr Ser Gly Ile Leu Gly Thr Thr His Ile Thr Glu
                3445                3450                3455    
Pro Ser Thr Gly Thr Ser His Thr Pro Ala Ala Thr Thr Gly Thr Thr
            3460                3465                3470        
Gln Pro Ser Thr Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr
        3475                3480                3485            
Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Arg
    3490                3495                3500                
Gly Thr Ser Arg Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr
3505                3510                3515                3520
Ser Thr Leu Leu Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val
                3525                3530                3535    
Val Thr Thr Gly Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp
            3540                3545                3550        
Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr
        3555                3560                3565            
Ser Asn Ile Arg Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly
    3570                3575                3580                
Leu Glu Cys Arg Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu
3585                3590                3595                3600
Gly Gln Val Val Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn
                3605                3610                3615    
Arg Glu Gln Val Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg
            3620                3625                3630        
Val Phe Cys Cys Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser
        3635                3640                3645            
Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr
    3650                3655                3660                
Lys Leu Thr Thr Thr Ala Thr Thr Thr Glu Ser Thr Gly Ser Thr Ala
3665                3670                3675                3680
Thr Pro Ser Ser Thr Gln Gly Pro Pro Ala Gly Thr Pro His Val Ser
                3685                3690                3695    
Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys Ala Thr Pro Phe
            3700                3705                3710        
Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala
        3715                3720                3725            
Thr Thr Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro Ser Ser Ser Leu
    3730                3735                3740                
Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Met Ala Thr
3745                3750                3755                3760
Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His Thr Ser
                3765                3770                3775    
Thr Val Leu Thr Thr Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser Val
            3780                3785                3790        
Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro
        3795                3800                3805            
Thr Thr Thr Thr Thr Gly Phe Thr Val Thr Pro Ser Ser Ser Pro Gly
    3810                3815                3820                
Thr Ala Arg Thr Pro Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr
3825                3830                3835                3840
Thr Ser Gly Ser Thr Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His
                3845                3850                3855    
Thr Pro Thr Val Leu Thr Thr Thr Thr Gln Pro Val Ala Thr Gly Ser
            3860                3865                3870        
Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser
        3875                3880                3885            
Leu Ile Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn
    3890                3895                3900                
Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro Glu Leu Thr Thr
3905                3910                3915                3920
Thr Ala Thr Thr Pro Ala Ala Thr Ser Ser Thr Val Thr Pro Ser Ser
                3925                3930                3935    
Ala Leu Gly Thr Thr His Thr Pro Pro Val Pro Asn Thr Thr Ala Thr
            3940                3945                3950        
Thr His Gly Arg Ser Leu Ser Pro Ser Ser Pro His Thr Val Arg Thr
        3955                3960                3965            
Ala Trp Thr Ser Ala Thr Ser Gly Thr Leu Gly Thr Thr His Ile Thr
    3970                3975                3980                
Glu Pro Ser Thr Gly Thr Ser His Thr Pro Ala Ala Thr Thr Gly Thr
3985                3990                3995                4000
Thr Thr Thr Ser Thr Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg
                4005                4010                4015    
Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr
            4020                4025                4030        
Thr Ala Thr Ser Arg Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg
        4035                4040                4045            
Thr Ser Thr Leu Leu Pro Ser Gln Pro Thr Ser Ala Pro Ile Thr Thr
    4050                4055                4060                
Val Val Thr Thr Gly Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu
4065                4070                4075                4080
Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr
                4085                4090                4095    
Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu
            4100                4105                4110        
Gly Leu Glu Cys Arg Ala Gln Ala Gln Pro Gly Val Pro Leu Gly Glu
        4115                4120                4125            
Leu Gly Gln Val Val Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg
    4130                4135                4140                
Asn Arg Glu Gln Val Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile
4145                4150                4155                4160
Arg Val Phe Cys Cys Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr
                4165                4170                4175    
Ser Ser Thr Ala Met Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu
            4180                4185                4190        
Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr
        4195                4200                4205            
Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala Pro Pro Pro Lys Val Leu
    4210                4215                4220                
Thr Ser Pro Ala Thr Thr Pro Thr Ala Thr Ser Ser Lys Ala Thr Ser
4225                4230                4235                4240
Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro Val Leu Thr Ser Thr
                4245                4250                4255    
Ala Thr Lys Ser Thr Ala Thr Ser Val Thr Pro Ile Pro Ser Ser Thr
            4260                4265                4270        
Leu Gly Thr Thr Gly Thr Leu Pro Glu Gln Thr Thr Thr Pro Val Ala
        4275                4280                4285            
Thr Met Ser Thr Ile His Pro Ser Ser Thr Pro Glu Thr Thr His Thr
    4290                4295                4300                
Ser Thr Val Leu Thr Thr Lys Ala Thr Thr Arg Ala Thr Ser Ser Thr
4305                4310                4315                4320
Ser Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu
                4325                4330                4335    
Thr Thr Ala Ala Thr Thr Thr Ala Gly Thr Gly Pro Thr Ala Thr Pro
            4340                4345                4350        
Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr
        4355                4360                4365            
Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Leu Ser Ser Thr
    4370                4375                4380                
Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val
4385                4390                4395                4400
Thr Val Pro Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala Thr
                4405                4410                4415    
Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro Thr Val Thr
            4420                4425                4430        
Ser Ser Lys Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu
        4435                4440                4445            
Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr
    4450                4455                4460                
Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln
4465                4470                4475                4480
Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr
                4485                4490                4495    
Pro Glu Thr Val His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Thr
            4500                4505                4510        
Thr Gly Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr
        4515                4520                4525            
Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala
    4530                4535                4540                
Thr Pro Ser Ser Ser Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile
4545                4550                4555                4560
Ser Thr Thr Thr Thr Pro Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser
                4565                4570                4575    
Thr Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His Thr Ala Arg Val
            4580                4585                4590        
Leu Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro
        4595                4600                4605            
Ser Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr
    4610                4615                4620                
Ala Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr
4625                4630                4635                4640
Pro Gly Thr Thr Pro Ile Pro Pro Val Leu Thr Ser Met Ala Thr Thr
                4645                4650                4655    
Pro Ala Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr
            4660                4665                4670        
Ala Thr Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala
        4675                4680                4685            
Thr Ser Phe Thr Pro Ile Pro Ser Ser Thr Leu Trp Thr Thr Trp Thr
    4690                4695                4700                
Val Pro Ala Gln Thr Thr Thr Pro Met Ser Thr Met Ser Thr Ile His
4705                4710                4715                4720
Thr Ser Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr
                4725                4730                4735    
Thr Ala Thr Met Thr Arg Ala Thr Asn Ser Thr Ala Thr Pro Ser Ser
            4740                4745                4750        
Thr Leu Gly Thr Thr Arg Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr
        4755                4760                4765            
Thr Thr Ala Ala Thr Gly Ser Thr Ala Thr Leu Ser Ser Thr Pro Gly
    4770                4775                4780                
Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Ile Ala Thr Val Met Val
4785                4790                4795                4800
Pro Thr Gly Ser Thr Ala Thr Thr Ser Ser Thr Leu Gly Thr Ala His
                4805                4810                4815    
Thr Pro Lys Val Val Thr Ala Met Ala Thr Met Pro Thr Ala Thr Ala
            4820                4825                4830        
Ser Thr Val Pro Ser Ser Ser Thr Val Gly Thr Thr Arg Thr Pro Ala
        4835                4840                4845            
Val Leu Pro Ser Ser Leu Pro Thr Phe Ser Val Ser Thr Val Ser Ser
    4850                4855                4860                
Ser Val Leu Thr Thr Leu Arg Pro Thr Gly Phe Pro Ser Ser His Phe
4865                4870                4875                4880
Ser Thr Pro Cys Phe Cys Arg Ala Phe Gly Gln Phe Phe Ser Pro Gly
                4885                4890                4895    
Glu Val Ile Tyr Asn Lys Thr Asp Arg Ala Gly Cys His Phe Tyr Ala
            4900                4905                4910        
Val Cys Asn Gln His Cys Asp Ile Asp Arg Phe Gln Gly Ala Cys Pro
        4915                4920                4925            
Thr Ser Pro Pro Pro Val Ser Ser Ala Pro Leu Ser Ser Pro Ser Pro
    4930                4935                4940                
Ala Pro Gly Cys Asp Asn Ala Ile Pro Leu Arg Gln Val Asn Glu Thr
4945                4950                4955                4960
Trp Thr Leu Glu Asn Cys Thr Val Ala Arg Cys Val Gly Asp Asn Arg
                4965                4970                4975    
Val Val Leu Leu Asp Pro Lys Pro Val Ala Asn Val Thr Cys Val Asn
            4980                4985                4990        
Lys His Leu Pro Ile Lys Val Ser Asp Pro Ser Gln Pro Cys Asp Phe
        4995                5000                5005            
His Tyr Glu Cys Glu Cys Ile Cys Ser Met Trp Gly Gly Ser His Tyr
    5010                5015                5020                
Ser Thr Phe Asp Gly Thr Ser Tyr Thr Phe Arg Gly Asn Cys Thr Tyr
5025                5030                5035                5040
Val Leu Met Arg Glu Ile His Ala Arg Phe Gly Asn Leu Ser Leu Tyr
                5045                5050                5055    
Leu Asp Asn His Tyr Cys Thr Ala Ser Ala Thr Ala Ala Ala Ala Arg
            5060                5065                5070        
Cys Pro Arg Ala Leu Ser Ile His Tyr Lys Ser Met Asp Ile Val Leu
        5075                5080                5085            
Thr Val Thr Met Val His Gly Lys Glu Glu Gly Leu Ile Leu Phe Asp
    5090                5095                5100                
Gln Ile Pro Val Ser Ser Gly Phe Ser Lys Asn Gly Val Leu Val Ser
5105                5110                5115                5120
Val Leu Gly Thr Thr Thr Met Arg Val Asp Ile Pro Ala Leu Gly Val
                5125                5130                5135    
Thr Val Thr Phe Asn Gly Gln Val Phe Gln Ala Arg Leu Pro Tyr Ser
            5140                5145                5150        
Leu Phe His Asn Asn Thr Glu Gly Gln Cys Gly Thr Cys Thr Asn Asn
        5155                5160                5165            
Gln Arg Asp Asp Cys Leu Gln Arg Asp Gly Thr Thr Ala Ala Ser Cys
    5170                5175                5180                
Lys Asp Met Ala Lys Thr Trp Leu Val Pro Asp Ser Arg Lys Asp Gly
5185                5190                5195                5200
Cys Trp Ala Pro Thr Gly Thr Pro Pro Thr Ala Ser Pro Ala Ala Pro
                5205                5210                5215    
Val Ser Ser Thr Pro Thr Pro Thr Pro Cys Pro Pro Gln Pro Leu Cys
            5220                5225                5230        
Asp Leu Met Leu Ser Gln Val Phe Ala Glu Cys His Asn Leu Val Pro
        5235                5240                5245            
Pro Gly Pro Phe Phe Asn Ala Cys Ile Ser Asp His Cys Arg Gly Arg
    5250                5255                5260                
Leu Glu Val Pro Cys Gln Ser Leu Glu Ala Tyr Ala Glu Leu Cys Arg
5265                5270                5275                5280
Ala Arg Gly Val Cys Ser Asp Trp Arg Gly Ala Thr Gly Gly Leu Cys
                5285                5290                5295    
Asp Leu Thr Cys Pro Pro Thr Lys Val Tyr Lys Pro Cys Gly Pro Ile
            5300                5305                5310        
Gln Pro Ala Thr Cys Asn Ser Arg Asn Gln Ser Pro Gln Leu Glu Gly
        5315                5320                5325            
Met Ala Glu Gly Cys Phe Cys Pro Glu Asp Gln Ile Leu Phe Asn Ala
    5330                5335                5340                
His Met Gly Ile Cys Val Gln Ala Cys Pro Cys Val Gly Pro Asp Gly
5345                5350                5355                5360
Phe Pro Lys Phe Pro Gly Glu Arg Trp Val Ser Asn Cys Gln Ser Cys
                5365                5370                5375    
Val Cys Asp Glu Gly Ser Val Ser Val Gln Cys Lys Pro Leu Pro Cys
            5380                5385                5390        
Asp Ala Gln Gly Gln Pro Pro Pro Cys Asn Arg Pro Gly Phe Val Thr
        5395                5400                5405            
Val Thr Arg Pro Arg Ala Glu Asn Pro Cys Cys Pro Glu Thr Val Cys
    5410                5415                5420                
Val Cys Asn Thr Thr Thr Cys Pro Gln Ser Leu Pro Val Cys Pro Pro
5425                5430                5435                5440
Gly Gln Glu Ser Ile Cys Thr Gln Glu Glu Gly Asp Cys Cys Pro Thr
                5445                5450                5455    
Phe Arg Cys Arg Pro Gln Leu Cys Ser Tyr Asn Gly Thr Phe Tyr Gly
            5460                5465                5470        
Val Gly Ala Thr Phe Pro Gly Ala Leu Pro Cys His Met Cys Thr Cys
        5475                5480                5485            
Leu Ser Gly Asp Thr Gln Asp Pro Thr Val Gln Cys Gln Glu Asp Ala
    5490                5495                5500                
Cys Asn Asn Thr Thr Cys Pro Gln Gly Phe Glu Tyr Lys Arg Val Ala
5505                5510                5515                5520
Gly Gln Cys Cys Gly Glu Cys Val Gln Thr Ala Cys Leu Thr Pro Asp
                5525                5530                5535    
Gly Gln Pro Val Gln Leu Asn Glu Thr Trp Val Asn Ser His Val Asp
            5540                5545                5550        
Asn Cys Thr Val Tyr Leu Cys Glu Ala Glu Gly Gly Val His Leu Leu
        5555                5560                5565            
Thr Pro Gln Pro Ala Ser Cys Pro Asp Val Ser Ser Cys Arg Gly Ser
    5570                5575                5580                
Leu Arg Lys Thr Gly Cys Cys Tyr Ser Cys Glu Glu Asp Ser Cys Gln
5585                5590                5595                5600
Val Arg Ile Asn Thr Thr Ile Leu Trp His Gln Gly Cys Glu Thr Glu
                5605                5610                5615    
Val Asn Ile Thr Phe Cys Glu Gly Ser Cys Pro Gly Ala Ser Lys Tyr
            5620                5625                5630        
Ser Ala Glu Ala Gln Ala Met Gln His Gln Cys Thr Cys Cys Gln Glu
        5635                5640                5645            
Arg Arg Val His Glu Glu Thr Val Pro Leu His Cys Pro Asn Gly Ser
    5650                5655                5660                
Ala Ile Leu His Thr Tyr Thr His Val Asp Glu Cys Gly Cys Thr Pro
5665                5670                5675                5680
Phe Cys Val Pro Ala Pro Met Ala Pro Pro His Thr Arg Gly Phe Pro
                5685                5690                5695    
Ala Gln Glu Ala Thr Ala Val
            5700            


<210> 5599
<211> 442
<212> PRT
<213> Homo sapiens

<400> 5599
Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala
 1               5                  10                  15      
Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu
            20                  25                  30          
Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe
        35                  40                  45              
Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys
    50                  55                  60                  
Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn
65                  70                  75                  80  
Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg
                85                  90                  95      
Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr
            100                 105                 110         
Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr
        115                 120                 125             
Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro
    130                 135                 140                 
Arg Asn Leu Met Ile Asp Ile Gln Arg Asp Thr Ala Val Glu Gly Glu
145                 150                 155                 160 
Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr
                165                 170                 175     
Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val
            180                 185                 190         
Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys
        195                 200                 205             
Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His
    210                 215                 220                 
Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln
225                 230                 235                 240 
Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu
                245                 250                 255     
Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys
            260                 265                 270         
Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro
        275                 280                 285             
Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn
    290                 295                 300                 
Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly
305                 310                 315                 320 
Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr
                325                 330                 335     
Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr
            340                 345                 350         
Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser
        355                 360                 365             
Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val
    370                 375                 380                 
Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala
385                 390                 395                 400 
Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp
                405                 410                 415     
Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn
            420                 425                 430         
Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile
        435                 440         


<210> 5600
<211> 443
<212> PRT
<213> Homo sapiens

<400> 5600
Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala
 1               5                  10                  15      
Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu
            20                  25                  30          
Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe
        35                  40                  45              
Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys
    50                  55                  60                  
Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn
65                  70                  75                  80  
Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg
                85                  90                  95      
Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr
            100                 105                 110         
Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr
        115                 120                 125             
Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro
    130                 135                 140                 
Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu
145                 150                 155                 160 
Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr
                165                 170                 175     
Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val
            180                 185                 190         
Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys
        195                 200                 205             
Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His
    210                 215                 220                 
Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln
225                 230                 235                 240 
Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu
                245                 250                 255     
Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys
            260                 265                 270         
Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro
        275                 280                 285             
Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn
    290                 295                 300                 
Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly
305                 310                 315                 320 
Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Thr Thr Ala Thr
                325                 330                 335     
Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu
            340                 345                 350         
Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly
        355                 360                 365             
Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val
    370                 375                 380                 
Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe
385                 390                 395                 400 
Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp
                405                 410                 415     
Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln
            420                 425                 430         
Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile
        435                 440             


<210> 5601
<211> 2813
<212> PRT
<213> Homo sapiens

<400> 5601
Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile
 1               5                  10                  15      
Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr
            20                  25                  30          
Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly
        35                  40                  45              
Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly
    50                  55                  60                  
Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys
65                  70                  75                  80  
Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu
                85                  90                  95      
Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro
            100                 105                 110         
Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys
        115                 120                 125             
Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly
    130                 135                 140                 
Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly
145                 150                 155                 160 
Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln
                165                 170                 175     
Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala
            180                 185                 190         
Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser
        195                 200                 205             
Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln
    210                 215                 220                 
Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu
225                 230                 235                 240 
Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu
                245                 250                 255     
Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala
            260                 265                 270         
Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His
        275                 280                 285             
Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys
    290                 295                 300                 
Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met
305                 310                 315                 320 
Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu
                325                 330                 335     
Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His
            340                 345                 350         
Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn
        355                 360                 365             
Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys
    370                 375                 380                 
Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp
385                 390                 395                 400 
Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg
                405                 410                 415     
Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys
            420                 425                 430         
Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu
        435                 440                 445             
Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val
    450                 455                 460                 
Ala Met Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu
465                 470                 475                 480 
Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu
                485                 490                 495     
Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu
            500                 505                 510         
Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn
        515                 520                 525             
Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro
    530                 535                 540                 
Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln
545                 550                 555                 560 
Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met
                565                 570                 575     
Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe
            580                 585                 590         
Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys
        595                 600                 605             
Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly
    610                 615                 620                 
Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val
625                 630                 635                 640 
Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln
                645                 650                 655     
Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu
            660                 665                 670         
Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe
        675                 680                 685             
Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys
    690                 695                 700                 
Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp
705                 710                 715                 720 
Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met
                725                 730                 735     
His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val
            740                 745                 750         
Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg
        755                 760                 765             
Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu
    770                 775                 780                 
Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met
785                 790                 795                 800 
Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg
                805                 810                 815     
His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln
            820                 825                 830         
Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr
        835                 840                 845             
Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp
    850                 855                 860                 
Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly
865                 870                 875                 880 
Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp
                885                 890                 895     
Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys
            900                 905                 910         
Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu
        915                 920                 925             
Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys
    930                 935                 940                 
Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg
945                 950                 955                 960 
Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg
                965                 970                 975     
His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val
            980                 985                 990         
Cys Gly Leu Cys Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr
        995                 1000                1005            
Ser Ser Asn Leu Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser
    1010                1015                1020                
Trp Lys Val Ser Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp
1025                1030                1035                1040
Ser Ser Pro Ala Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val
                1045                1050                1055    
Asp Ser Ser Cys Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn
            1060                1065                1070        
Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp Thr
        1075                1080                1085            
Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp Thr Ile
    1090                1095                1100                
Ala Ala Tyr Ala His Val Cys Ala Gln His Gly Lys Val Val Thr Trp
1105                1110                1115                1120
Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu Glu Arg Asn Leu Arg
                1125                1130                1135    
Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn Ser Cys Ala Pro Ala
            1140                1145                1150        
Cys Gln Val Thr Cys Gln His Pro Glu Pro Leu Ala Cys Pro Val Gln
        1155                1160                1165            
Cys Val Glu Gly Cys His Ala His Cys Pro Pro Gly Lys Ile Leu Asp
    1170                1175                1180                
Glu Leu Leu Gln Thr Cys Val Asp Pro Glu Asp Cys Pro Val Cys Glu
1185                1190                1195                1200
Val Ala Gly Arg Arg Phe Ala Ser Gly Lys Lys Val Thr Leu Asn Pro
                1205                1210                1215    
Ser Asp Pro Glu His Cys Gln Ile Cys His Cys Asp Val Val Asn Leu
            1220                1225                1230        
Thr Cys Glu Ala Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr
        1235                1240                1245            
Asp Ala Pro Val Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu
    1250                1255                1260                
Pro Pro Leu His Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe
1265                1270                1275                1280
Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu
                1285                1290                1295    
Lys Ala Phe Val Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys
            1300                1305                1310        
Trp Val Arg Val Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr
        1315                1320                1325            
Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala
    1330                1335                1340                
Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val
1345                1350                1355                1360
Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu
                1365                1370                1375    
Ala Ser Arg Ile Ala Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg
            1380                1385                1390        
Met Ser Arg Asn Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys
        1395                1400                1405            
Val Ile Val Ile Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln
    1410                1415                1420                
Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu
1425                1430                1435                1440
Ser Ser Val Asp Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr
                1445                1450                1455    
Leu Cys Asp Leu Ala Pro Glu Ala Pro Pro Pro Thr Leu Pro Pro His
            1460                1465                1470        
Met Ala Gln Val Thr Val Gly Pro Gly Leu Leu Gly Val Ser Thr Leu
        1475                1480                1485            
Gly Pro Lys Arg Asn Ser Met Val Leu Asp Val Ala Phe Val Leu Glu
    1490                1495                1500                
Gly Ser Asp Lys Ile Gly Glu Ala Asp Phe Asn Arg Ser Lys Glu Phe
1505                1510                1515                1520
Met Glu Glu Val Ile Gln Arg Met Asp Val Gly Gln Asp Ser Ile His
                1525                1530                1535    
Val Thr Val Leu Gln Tyr Ser Tyr Met Val Thr Val Glu Tyr Pro Phe
            1540                1545                1550        
Ser Glu Ala Gln Ser Lys Gly Asp Ile Leu Gln Arg Val Arg Glu Ile
        1555                1560                1565            
Arg Tyr Gln Gly Gly Asn Arg Thr Asn Thr Gly Leu Ala Leu Arg Tyr
    1570                1575                1580                
Leu Ser Asp His Ser Phe Leu Val Ser Gln Gly Asp Arg Glu Gln Ala
1585                1590                1595                1600
Pro Asn Leu Val Tyr Met Val Thr Gly Asn Pro Ala Ser Asp Glu Ile
                1605                1610                1615    
Lys Arg Leu Pro Gly Asp Ile Gln Val Val Pro Ile Gly Val Gly Pro
            1620                1625                1630        
Asn Ala Asn Val Gln Glu Leu Glu Arg Ile Gly Trp Pro Asn Ala Pro
        1635                1640                1645            
Ile Leu Ile Gln Asp Phe Glu Thr Leu Pro Arg Glu Ala Pro Asp Leu
    1650                1655                1660                
Val Leu Gln Arg Cys Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu
1665                1670                1675                1680
Ser Pro Ala Pro Asp Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu
                1685                1690                1695    
Asp Gly Ser Ser Ser Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser
            1700                1705                1710        
Phe Ala Lys Ala Phe Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr
        1715                1720                1725            
Gln Val Ser Val Leu Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro
    1730                1735                1740                
Trp Asn Val Val Pro Glu Lys Ala His Leu Leu Ser Leu Val Asp Val
1745                1750                1755                1760
Met Gln Arg Glu Gly Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe
                1765                1770                1775    
Ala Val Arg Tyr Leu Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala
            1780                1785                1790        
Ser Lys Ala Val Val Ile Leu Val Thr Asp Val Ser Val Asp Ser Val
        1795                1800                1805            
Asp Ala Ala Ala Asp Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro
    1810                1815                1820                
Ile Gly Ile Gly Asp Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala
1825                1830                1835                1840
Gly Pro Ala Gly Asp Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp
                1845                1850                1855    
Leu Pro Thr Met Val Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys
            1860                1865                1870        
Ser Gly Phe Val Arg Ile Cys Met Asp Glu Asp Gly Asn Glu Lys Arg
        1875                1880                1885            
Pro Gly Asp Val Trp Thr Leu Pro Asp Gln Cys His Thr Val Thr Cys
    1890                1895                1900                
Gln Pro Asp Gly Gln Thr Leu Leu Lys Ser His Arg Val Asn Cys Asp
1905                1910                1915                1920
Arg Gly Leu Arg Pro Ser Cys Pro Asn Ser Gln Ser Pro Val Lys Val
                1925                1930                1935    
Glu Glu Thr Cys Gly Cys Arg Trp Thr Cys Pro Cys Val Cys Thr Gly
            1940                1945                1950        
Ser Ser Thr Arg His Ile Val Thr Phe Asp Gly Gln Asn Phe Lys Leu
        1955                1960                1965            
Thr Gly Ser Cys Ser Tyr Val Leu Phe Gln Asn Lys Glu Gln Asp Leu
    1970                1975                1980                
Glu Val Ile Leu His Asn Gly Ala Cys Ser Pro Gly Ala Arg Gln Gly
1985                1990                1995                2000
Cys Met Lys Ser Ile Glu Val Lys His Ser Ala Leu Ser Val Glu Leu
                2005                2010                2015    
His Ser Asp Met Glu Val Thr Val Asn Gly Arg Leu Val Ser Val Pro
            2020                2025                2030        
Tyr Val Gly Gly Asn Met Glu Val Asn Val Tyr Gly Ala Ile Met His
        2035                2040                2045            
Glu Val Arg Phe Asn His Leu Gly His Ile Phe Thr Phe Thr Pro Gln
    2050                2055                2060                
Asn Asn Glu Phe Gln Leu Gln Leu Ser Pro Lys Thr Phe Ala Ser Lys
2065                2070                2075                2080
Thr Tyr Gly Leu Cys Gly Ile Cys Asp Glu Asn Gly Ala Asn Asp Phe
                2085                2090                2095    
Met Leu Arg Asp Gly Thr Val Thr Thr Asp Trp Lys Thr Leu Val Gln
            2100                2105                2110        
Glu Trp Thr Val Gln Arg Pro Gly Gln Thr Cys Gln Pro Ile Leu Glu
        2115                2120                2125            
Glu Gln Cys Leu Val Pro Asp Ser Ser His Cys Gln Val Leu Leu Leu
    2130                2135                2140                
Pro Leu Phe Ala Glu Cys His Lys Val Leu Ala Pro Ala Thr Phe Tyr
2145                2150                2155                2160
Ala Ile Cys Gln Gln Asp Ser Cys His Gln Glu Gln Val Cys Glu Val
                2165                2170                2175    
Ile Ala Ser Tyr Ala His Leu Cys Arg Thr Asn Gly Val Cys Val Asp
            2180                2185                2190        
Trp Arg Thr Pro Asp Phe Cys Ala Met Ser Cys Pro Pro Ser Leu Val
        2195                2200                2205            
Tyr Asn His Cys Glu His Gly Cys Pro Arg His Cys Asp Gly Asn Val
    2210                2215                2220                
Ser Ser Cys Gly Asp His Pro Ser Glu Gly Cys Phe Cys Pro Pro Asp
2225                2230                2235                2240
Lys Val Met Leu Glu Gly Ser Cys Val Pro Glu Glu Ala Cys Thr Gln
                2245                2250                2255    
Cys Ile Gly Glu Asp Gly Val Gln His Gln Phe Leu Glu Ala Trp Val
            2260                2265                2270        
Pro Asp His Gln Pro Cys Gln Ile Cys Thr Cys Leu Ser Gly Arg Lys
        2275                2280                2285            
Val Asn Cys Thr Thr Gln Pro Cys Pro Thr Ala Lys Ala Pro Thr Cys
    2290                2295                2300                
Gly Leu Cys Glu Val Ala Arg Leu Arg Gln Asn Ala Asp Gln Cys Cys
2305                2310                2315                2320
Pro Glu Tyr Glu Cys Val Cys Asp Pro Val Ser Cys Asp Leu Pro Pro
                2325                2330                2335    
Val Pro His Cys Glu Arg Gly Leu Gln Pro Thr Leu Thr Asn Pro Gly
            2340                2345                2350        
Glu Cys Arg Pro Asn Phe Thr Cys Ala Cys Arg Lys Glu Glu Cys Lys
        2355                2360                2365            
Arg Val Ser Pro Pro Ser Cys Pro Pro His Arg Leu Pro Thr Leu Arg
    2370                2375                2380                
Lys Thr Gln Cys Cys Asp Glu Tyr Glu Cys Ala Cys Asn Cys Val Asn
2385                2390                2395                2400
Ser Thr Val Ser Cys Pro Leu Gly Tyr Leu Ala Ser Thr Ala Thr Asn
                2405                2410                2415    
Asp Cys Gly Cys Thr Thr Thr Thr Cys Leu Pro Asp Lys Val Cys Val
            2420                2425                2430        
His Arg Ser Thr Ile Tyr Pro Val Gly Gln Phe Trp Glu Glu Gly Cys
        2435                2440                2445            
Asp Val Cys Thr Cys Thr Asp Met Glu Asp Ala Val Met Gly Leu Arg
    2450                2455                2460                
Val Ala Gln Cys Ser Gln Lys Pro Cys Glu Asp Ser Cys Arg Ser Gly
2465                2470                2475                2480
Phe Thr Tyr Val Leu His Glu Gly Glu Cys Cys Gly Arg Cys Leu Pro
                2485                2490                2495    
Ser Ala Cys Glu Val Val Thr Gly Ser Pro Arg Gly Asp Ser Gln Ser
            2500                2505                2510        
Ser Trp Lys Ser Val Gly Ser Gln Trp Ala Ser Pro Glu Asn Pro Cys
        2515                2520                2525            
Leu Ile Asn Glu Cys Val Arg Val Lys Glu Glu Val Phe Ile Gln Gln
    2530                2535                2540                
Arg Asn Val Ser Cys Pro Gln Leu Glu Val Pro Val Cys Pro Ser Gly
2545                2550                2555                2560
Phe Gln Leu Ser Cys Lys Thr Ser Ala Cys Cys Pro Ser Cys Arg Cys
                2565                2570                2575    
Glu Arg Met Glu Ala Cys Met Leu Asn Gly Thr Val Ile Gly Pro Gly
            2580                2585                2590        
Lys Thr Val Met Ile Asp Val Cys Thr Thr Cys Arg Cys Met Val Gln
        2595                2600                2605            
Val Gly Val Ile Ser Gly Phe Lys Leu Glu Cys Arg Lys Thr Thr Cys
    2610                2615                2620                
Asn Pro Cys Pro Leu Gly Tyr Lys Glu Glu Asn Asn Thr Gly Glu Cys
2625                2630                2635                2640
Cys Gly Arg Cys Leu Pro Thr Ala Cys Thr Ile Gln Leu Arg Gly Gly
                2645                2650                2655    
Gln Ile Met Thr Leu Lys Arg Asp Glu Thr Leu Gln Asp Gly Cys Asp
            2660                2665                2670        
Thr His Phe Cys Lys Val Asn Glu Arg Gly Glu Tyr Phe Trp Glu Lys
        2675                2680                2685            
Arg Val Thr Gly Cys Pro Pro Phe Asp Glu His Lys Cys Leu Ala Glu
    2690                2695                2700                
Gly Gly Lys Ile Met Lys Ile Pro Gly Thr Cys Cys Asp Thr Cys Glu
2705                2710                2715                2720
Glu Pro Glu Cys Asn Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys Val
                2725                2730                2735    
Gly Ser Cys Lys Ser Glu Val Glu Val Asp Ile His Tyr Cys Gln Gly
            2740                2745                2750        
Lys Cys Ala Ser Lys Ala Met Tyr Ser Ile Asp Ile Asn Asp Val Gln
        2755                2760                2765            
Asp Gln Cys Ser Cys Cys Ser Pro Thr Arg Thr Glu Pro Met Gln Val
    2770                2775                2780                
Ala Leu His Cys Thr Asn Gly Ser Val Val Tyr His Glu Val Leu Asn
2785                2790                2795                2800
Ala Met Glu Cys Lys Cys Ser Pro Arg Lys Cys Ser Lys
                2805                2810            


<210> 5602
<211> 923
<212> PRT
<213> Homo sapiens

<400> 5602
Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu
 1               5                  10                  15      
Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys
            20                  25                  30          
Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr
        35                  40                  45              
His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr
    50                  55                  60                  
Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg
65                  70                  75                  80  
Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn
                85                  90                  95      
Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val
            100                 105                 110         
Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu
        115                 120                 125             
Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly
    130                 135                 140                 
Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser
145                 150                 155                 160 
Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile
                165                 170                 175     
Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe
            180                 185                 190         
Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr
        195                 200                 205             
Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile
    210                 215                 220                 
Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser
225                 230                 235                 240 
Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu
                245                 250                 255     
Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp
            260                 265                 270         
Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser
        275                 280                 285             
Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu
    290                 295                 300                 
Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp
305                 310                 315                 320 
Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val
                325                 330                 335     
Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys
            340                 345                 350         
Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp
        355                 360                 365             
Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn
    370                 375                 380                 
Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile
385                 390                 395                 400 
Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser
                405                 410                 415     
Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser
            420                 425                 430         
Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr
        435                 440                 445             
Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu
    450                 455                 460                 
Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr
465                 470                 475                 480 
Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg
                485                 490                 495     
Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met
            500                 505                 510         
Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met
        515                 520                 525             
Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn
    530                 535                 540                 
Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg
545                 550                 555                 560 
Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu
                565                 570                 575     
Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro
            580                 585                 590         
Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala
        595                 600                 605             
Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr
    610                 615                 620                 
Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln
625                 630                 635                 640 
Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser
                645                 650                 655     
His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys
            660                 665                 670         
Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly
        675                 680                 685             
Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys
    690                 695                 700                 
Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His
705                 710                 715                 720 
Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu
                725                 730                 735     
Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val
            740                 745                 750         
Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val
        755                 760                 765             
Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu
    770                 775                 780                 
Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile
785                 790                 795                 800 
Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp
                805                 810                 815     
Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly
            820                 825                 830         
Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly
        835                 840                 845             
Asn Val Leu Lys Thr Leu Glu Pro Ile Leu Ile Thr Ile Ile Ala Met
    850                 855                 860                 
Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr
865                 870                 875                 880 
Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu
                885                 890                 895     
Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp
            900                 905                 910         
Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala
        915                 920             


<210> 5603
<211> 609
<212> PRT
<213> Homo sapiens

<400> 5603
Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu
 1               5                  10                  15      
Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys
            20                  25                  30          
Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr
        35                  40                  45              
His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr
    50                  55                  60                  
Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg
65                  70                  75                  80  
Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn
                85                  90                  95      
Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val
            100                 105                 110         
Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu
        115                 120                 125             
Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly
    130                 135                 140                 
Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser
145                 150                 155                 160 
Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile
                165                 170                 175     
Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe
            180                 185                 190         
Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr
        195                 200                 205             
Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile
    210                 215                 220                 
Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser
225                 230                 235                 240 
Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu
                245                 250                 255     
Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp
            260                 265                 270         
Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser
        275                 280                 285             
Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu
    290                 295                 300                 
Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp
305                 310                 315                 320 
Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val
                325                 330                 335     
Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys
            340                 345                 350         
Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp
        355                 360                 365             
Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn
    370                 375                 380                 
Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile
385                 390                 395                 400 
Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser
                405                 410                 415     
Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser
            420                 425                 430         
Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr
        435                 440                 445             
Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu
    450                 455                 460                 
Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr
465                 470                 475                 480 
Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg
                485                 490                 495     
Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met
            500                 505                 510         
Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met
        515                 520                 525             
Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn
    530                 535                 540                 
Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg
545                 550                 555                 560 
Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu
                565                 570                 575     
Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu
            580                 585                 590         
Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile
        595                 600                 605             
Lys
    


<210> 5604
<211> 538
<212> PRT
<213> Homo sapiens

<400> 5604
Met Val Ala Glu Val Ser Pro Lys Leu Ala Ala Ser Pro Met Lys Lys
 1               5                  10                  15      
Pro Phe Gly Phe Arg Gly Lys Met Gly Lys Trp Cys Cys Cys Cys Phe
            20                  25                  30          
Pro Cys Cys Arg Gly Ser Gly Lys Asn Asn Met Gly Ala Trp Arg Asp
        35                  40                  45              
His Asp Asp Ser Ala Phe Thr Glu Pro Arg Tyr His Val Arg Arg Glu
    50                  55                  60                  
Asp Leu Gly Lys Leu His Arg Ala Ala Trp Trp Gly Glu Val Pro Arg
65                  70                  75                  80  
Ala Asp Leu Ile Val Met Leu Arg Gly Pro Gly Ile Asn Lys Arg Asp
                85                  90                  95      
Lys Lys Lys Arg Lys Lys Arg Phe Gly Arg Thr Ala Leu His Leu Ala
            100                 105                 110         
Cys Ala Asn Gly Asn Ser Glu Val Val Ser Leu Leu Leu Asp Arg Gln
        115                 120                 125             
Cys Gln Leu His Val Phe Asp Ser Lys Lys Arg Thr Ala Leu Ile Lys
    130                 135                 140                 
Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met Leu Leu Gln His
145                 150                 155                 160 
Gly Thr Asp Pro Asn Leu Pro Asp Met Tyr Gly Asn Thr Ala Leu His
                165                 170                 175     
Tyr Ala Val Tyr Asn Glu Asp Lys Leu Met Ala Lys Thr Leu Leu Leu
            180                 185                 190         
Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys Gly Gly Leu Thr Pro Leu
        195                 200                 205             
Leu Leu Ala Val His Gly Gln Lys Gln Arg Met Val Lys Phe Leu Ile
    210                 215                 220                 
Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Phe Gly Arg Thr Ala
225                 230                 235                 240 
Leu Ile Leu Ala Val Arg Cys Gly Ser Ala Ser Ile Val Ser Leu Leu
                245                 250                 255     
Leu Gln Gln Asn Ile Asp Val Phe Ser Gln Asp Val Phe Gly Gln Thr
            260                 265                 270         
Ala Glu Asp Tyr Ala Val Ser Ser His His Ser Ile Ile Cys Gln Leu
        275                 280                 285             
Leu Ser Asp Tyr Lys Glu Asn Gln Met Pro Asn Asn Ser Ser Gly Asn
    290                 295                 300                 
Ser Asn Pro Ala Ile Thr Val Leu Asn Ile Lys Leu Pro Leu Lys Val
305                 310                 315                 320 
Glu Glu Glu Met Gln Lys His Gly Ser Asn Asn Val Gly Leu Ser Glu
                325                 330                 335     
Asn Leu Thr Asp Gly Ala Ala Ala Gly Asn Gly Asp Gly Gly Leu Val
            340                 345                 350         
Pro Gln Arg Lys Ser Arg Lys His Glu Asn Gln Gln Phe Pro Asn Thr
        355                 360                 365             
Glu Ile Glu Glu Tyr His Ser Glu Glu Gln Asn Asp Thr Arg Lys Gln
    370                 375                 380                 
Leu Ser Lys Glu Gln Asn Ala Arg Ile Leu Gln Asp Glu Ile Leu Thr
385                 390                 395                 400 
Thr Lys Gln Lys Gln Ile Glu Val Ala Glu Lys Lys Met Asn Phe Glu
                405                 410                 415     
Ile Ser Leu Ser His Lys Glu Glu Lys Glu Leu Leu His Glu Asn Ser
            420                 425                 430         
Met Met Gln Glu Glu Ile Ala Met Leu Arg Ile Glu Leu Asp Thr Ile
        435                 440                 445             
Lys His Gln Asn Gln Leu Arg Glu Lys Lys Tyr Leu Glu Tyr Ile Lys
    450                 455                 460                 
Ser Val Lys Glu Lys Asn Asp Asn Leu Leu Lys Ala Ile Gln Leu Asn
465                 470                 475                 480 
Glu Glu Ala Leu Thr Lys Ala Val Val Gln Tyr Ser Gly Gln Leu Ser
                485                 490                 495     
Ile Leu Thr Thr Glu Asn Lys Met Leu Ser Phe Glu Leu Gln Asn Val
            500                 505                 510         
Arg His Asn Asn Glu Thr Leu Glu Met Glu Ile Gln Ser Cys His Phe
        515                 520                 525             
Arg Leu Ala Thr Ala Leu His Asp Cys Asp
    530                 535             


<210> 5605
<211> 120
<212> PRT
<213> Homo sapiens

<400> 5605
Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln
 1               5                  10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ser Thr
            20                  25                  30          
Gly Met Cys Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Asn Thr Ser
    50                  55                  60                  
Leu Glu Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val
65                  70                  75                  80  
Val Leu Thr Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg
                85                  90                  95      
Ile Thr Val Ile Pro Ala Pro Ala Gly Tyr Met Asp Val Trp Gly Arg
            100                 105                 110         
Gly Thr Pro Val Thr Val Ser Ser
        115                 120 


<210> 5606
<211> 739
<212> PRT
<213> Homo sapiens

<400> 5606
Met Phe Leu Leu Leu Ala Leu Leu Thr Glu Leu Gly Arg Leu Gln Ala
 1               5                  10                  15      
His Glu Gly Ser Glu Gly Ile Phe Leu His Val Thr Val Pro Arg Lys
            20                  25                  30          
Ile Lys Ser Asn Asp Ser Glu Val Ser Glu Arg Lys Met Ile Tyr Ile
        35                  40                  45              
Ile Thr Ile Asp Gly Gln Pro Tyr Thr Leu His Leu Gly Lys Gln Ser
    50                  55                  60                  
Phe Leu Pro Gln Asn Phe Leu Val Tyr Thr Tyr Asn Glu Thr Gly Ser
65                  70                  75                  80  
Leu His Ser Val Ser Pro Tyr Phe Met Met His Cys His Tyr Gln Gly
                85                  90                  95      
Tyr Ala Ala Glu Phe Pro Asn Ser Phe Val Thr Leu Ser Ile Cys Ser
            100                 105                 110         
Gly Leu Arg Gly Phe Leu Gln Phe Glu Asn Ile Ser Tyr Gly Ile Glu
        115                 120                 125             
Pro Val Glu Ser Ser Ala Arg Phe Glu His Ile Ile Tyr Gln Met Lys
    130                 135                 140                 
Asn Asn Asp Pro Asn Val Ser Ile Leu Ala Val Asn Tyr Ser His Ile
145                 150                 155                 160 
Trp Gln Lys Asp Gln Pro Tyr Lys Val Pro Leu Asn Ser Gln Ile Lys
                165                 170                 175     
Asn Leu Ser Lys Leu Leu Pro Gln Tyr Leu Glu Ile Tyr Ile Ile Val
            180                 185                 190         
Glu Lys Ala Leu Tyr Asp Tyr Met Gly Ser Glu Met Met Ala Val Thr
        195                 200                 205             
Gln Lys Ile Val Gln Val Ile Gly Leu Val Asn Thr Met Phe Thr Gln
    210                 215                 220                 
Phe Lys Leu Thr Val Ile Leu Ser Ser Leu Glu Leu Trp Ser Asn Glu
225                 230                 235                 240 
Asn Gln Ile Ser Thr Ser Gly Asp Ala Asp Asp Ile Leu Gln Arg Phe
                245                 250                 255     
Leu Ala Trp Lys Arg Asp Tyr Leu Ile Leu Arg Pro His Asp Ile Ala
            260                 265                 270         
Tyr Leu Leu Val Tyr Arg Lys His Pro Lys Tyr Val Gly Ala Thr Phe
        275                 280                 285             
Pro Gly Thr Val Cys Asn Lys Ser Tyr Asp Ala Gly Ile Ala Met Tyr
    290                 295                 300                 
Pro Asp Ala Ile Gly Leu Glu Gly Phe Ser Val Ile Ile Ala Gln Leu
305                 310                 315                 320 
Leu Gly Leu Asn Val Gly Leu Thr Tyr Asp Asp Ile Thr Gln Cys Phe
                325                 330                 335     
Cys Leu Arg Ala Thr Cys Ile Met Asn His Glu Ala Val Ser Ala Ser
            340                 345                 350         
Gly Arg Lys Ile Phe Ser Asn Cys Ser Met His Asp Tyr Arg Tyr Phe
        355                 360                 365             
Val Ser Lys Phe Glu Thr Lys Cys Leu Gln Lys Leu Ser Asn Leu Gln
    370                 375                 380                 
Pro Leu His Gln Asn Gln Pro Val Cys Gly Asn Gly Ile Leu Glu Ser
385                 390                 395                 400 
Asn Glu Glu Cys Asp Cys Gly Asn Lys Asn Glu Cys Gln Phe Lys Lys
                405                 410                 415     
Cys Cys Asp Tyr Asn Thr Cys Lys Leu Lys Gly Ser Val Lys Cys Gly
            420                 425                 430         
Ser Gly Pro Cys Cys Thr Ser Lys Cys Glu Leu Ser Ile Ala Gly Thr
        435                 440                 445             
Pro Cys Arg Lys Ser Ile Asp Pro Glu Cys Asp Phe Thr Glu Tyr Cys
    450                 455                 460                 
Asn Gly Thr Ser Ser Asn Cys Val Pro Asp Thr Tyr Ala Leu Asn Gly
465                 470                 475                 480 
Arg Leu Cys Lys Leu Gly Thr Ala Tyr Cys Tyr Asn Gly Gln Cys Gln
                485                 490                 495     
Thr Thr Asp Asn Gln Cys Ala Lys Ile Phe Gly Lys Gly Ala Gln Gly
            500                 505                 510         
Ala Pro Phe Ala Cys Phe Lys Glu Val Asn Ser Leu His Glu Arg Ser
        515                 520                 525             
Glu Asn Cys Gly Phe Lys Asn Ser Gln Pro Leu Pro Cys Glu Arg Lys
    530                 535                 540                 
Asp Val Leu Cys Gly Lys Leu Ala Cys Val Gln Pro His Lys Asn Ala
545                 550                 555                 560 
Asn Lys Ser Asp Ala Gln Ser Thr Val Tyr Ser Tyr Ile Gln Asp His
                565                 570                 575     
Val Cys Val Ser Ile Ala Thr Gly Ser Ser Met Arg Ser Asp Gly Thr
            580                 585                 590         
Asp Asn Ala Tyr Val Ala Asp Gly Thr Met Cys Gly Pro Glu Met Tyr
        595                 600                 605             
Cys Val Asn Lys Thr Cys Arg Lys Val His Leu Met Gly Tyr Asn Cys
    610                 615                 620                 
Asn Ala Thr Thr Lys Cys Lys Gly Lys Gly Ile Cys Asn Asn Phe Gly
625                 630                 635                 640 
Asn Cys Gln Cys Phe Pro Gly His Arg Pro Pro Asp Cys Lys Phe Gln
                645                 650                 655     
Phe Gly Ser Pro Gly Gly Ser Ile Asp Asp Gly Asn Phe Gln Lys Ser
            660                 665                 670         
Gly Asp Phe Tyr Thr Glu Lys Gly Tyr Asn Thr His Trp Asn Asn Trp
        675                 680                 685             
Phe Ile Leu Ser Phe Cys Ile Phe Leu Pro Phe Phe Ile Val Phe Thr
    690                 695                 700                 
Thr Val Ile Phe Lys Arg Asn Glu Ile Ser Lys Ser Cys Asn Arg Glu
705                 710                 715                 720 
Asn Ala Glu Tyr Asn Arg Asn Ser Ser Val Val Ser Glu Ser Asp Asp
                725                 730                 735     
Val Gly His
            


<210> 5607
<211> 2976
<212> PRT
<213> Homo sapiens

<400> 5607
Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe
 1               5                  10                  15      
Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val
            20                  25                  30          
Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp
        35                  40                  45              
Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp
    50                  55                  60                  
Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu
65                  70                  75                  80  
Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr
                85                  90                  95      
Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile
            100                 105                 110         
Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser
        115                 120                 125             
His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln
    130                 135                 140                 
Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu
145                 150                 155                 160 
Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly
                165                 170                 175     
Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro
            180                 185                 190         
Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp
        195                 200                 205             
Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu
    210                 215                 220                 
Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser
225                 230                 235                 240 
Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val
                245                 250                 255     
Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu
            260                 265                 270         
Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp
        275                 280                 285             
Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln
    290                 295                 300                 
Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala
305                 310                 315                 320 
Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg
                325                 330                 335     
Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu
            340                 345                 350         
Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala
        355                 360                 365             
Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala
    370                 375                 380                 
Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe
385                 390                 395                 400 
Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu
                405                 410                 415     
Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro
            420                 425                 430         
Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe
        435                 440                 445             
Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile
    450                 455                 460                 
Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp
465                 470                 475                 480 
Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu
                485                 490                 495     
Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val
            500                 505                 510         
Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala
        515                 520                 525             
Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg
    530                 535                 540                 
Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys
545                 550                 555                 560 
Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser
                565                 570                 575     
Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu
            580                 585                 590         
Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe
        595                 600                 605             
Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu
    610                 615                 620                 
Arg Thr Leu Ser Gly Thr Pro Glu Glu Ser Lys Arg Asp Ile Leu Phe
625                 630                 635                 640 
Leu Phe Asp Gly Ser Ala Asn Leu Val Gly Gln Phe Pro Val Val Arg
                645                 650                 655     
Asp Phe Leu Tyr Lys Ile Ile Asp Glu Leu Asn Val Lys Pro Glu Gly
            660                 665                 670         
Thr Arg Ile Ala Val Ala Gln Tyr Ser Asp Asp Val Lys Val Glu Ser
        675                 680                 685             
Arg Phe Asp Glu His Gln Ser Lys Pro Glu Ile Leu Asn Leu Val Lys
    690                 695                 700                 
Arg Met Lys Ile Lys Thr Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu
705                 710                 715                 720 
Asp Tyr Ala Gln Arg Tyr Ile Phe Val Lys Ser Ala Gly Ser Arg Ile
                725                 730                 735     
Glu Asp Gly Val Leu Gln Phe Leu Val Leu Leu Val Ala Gly Arg Ser
            740                 745                 750         
Ser Asp Arg Val Asp Gly Pro Ala Ser Asn Leu Lys Gln Ser Gly Val
        755                 760                 765             
Val Pro Phe Ile Phe Gln Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu
    770                 775                 780                 
Gln Ile Val Leu Ser Pro Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro
785                 790                 795                 800 
Lys Ile Gly Asp Leu His Pro Gln Ile Val Asn Leu Leu Lys Ser Val
                805                 810                 815     
His Asn Gly Ala Pro Ala Pro Val Ser Gly Glu Lys Asp Val Val Phe
            820                 825                 830         
Leu Leu Asp Gly Ser Glu Gly Val Arg Ser Gly Phe Pro Leu Leu Lys
        835                 840                 845             
Glu Phe Val Gln Arg Val Val Glu Ser Leu Asp Val Gly Gln Asp Arg
    850                 855                 860                 
Val Arg Val Ala Val Val Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe
865                 870                 875                 880 
Tyr Leu Asn Ser Tyr Met Asn Lys Gln Asp Val Val Asn Ala Val Arg
                885                 890                 895     
Gln Leu Thr Leu Leu Gly Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu
            900                 905                 910         
Glu Phe Val Leu Arg Asn Ile Leu Val Ser Ser Ala Gly Ser Arg Ile
        915                 920                 925             
Thr Glu Gly Val Pro Gln Leu Leu Ile Val Leu Thr Ala Asp Arg Ser
    930                 935                 940                 
Gly Asp Asp Val Arg Asn Pro Ser Val Val Val Lys Arg Gly Gly Ala
945                 950                 955                 960 
Val Pro Ile Gly Ile Gly Ile Gly Asn Ala Asp Ile Thr Glu Met Gln
                965                 970                 975     
Thr Ile Ser Phe Ile Pro Asp Phe Ala Val Ala Ile Pro Thr Phe Arg
            980                 985                 990         
Gln Leu Gly Thr Val Gln Gln Val Ile Ser Glu Arg Val Thr Gln Leu
        995                 1000                1005            
Thr Arg Glu Glu Leu Ser Arg Leu Gln Pro Val Leu Gln Pro Leu Pro
    1010                1015                1020                
Ser Pro Gly Val Gly Gly Lys Arg Asp Val Val Phe Leu Ile Asp Gly
1025                1030                1035                1040
Ser Gln Ser Ala Gly Pro Glu Phe Gln Tyr Val Arg Thr Leu Ile Glu
                1045                1050                1055    
Arg Leu Val Asp Tyr Leu Asp Val Gly Phe Asp Thr Thr Arg Val Ala
            1060                1065                1070        
Val Ile Gln Phe Ser Asp Asp Pro Lys Ala Glu Phe Leu Leu Asn Ala
        1075                1080                1085            
His Ser Ser Lys Asp Glu Val Gln Asn Ala Val Gln Arg Leu Arg Pro
    1090                1095                1100                
Lys Gly Gly Arg Gln Ile Asn Val Gly Asn Ala Leu Glu Tyr Val Ser
1105                1110                1115                1120
Arg Asn Ile Phe Lys Arg Pro Leu Gly Ser Arg Ile Glu Glu Gly Val
                1125                1130                1135    
Pro Gln Phe Leu Val Leu Ile Ser Ser Gly Lys Ser Asp Asp Glu Val
            1140                1145                1150        
Val Val Pro Ala Val Glu Leu Lys Gln Phe Gly Val Ala Pro Phe Thr
        1155                1160                1165            
Ile Ala Arg Asn Ala Asp Gln Glu Glu Leu Val Lys Ile Ser Leu Ser
    1170                1175                1180                
Pro Glu Tyr Val Phe Ser Val Ser Thr Phe Arg Glu Leu Pro Ser Leu
1185                1190                1195                1200
Glu Gln Lys Leu Leu Thr Pro Ile Thr Thr Leu Thr Ser Glu Gln Ile
                1205                1210                1215    
Gln Lys Leu Leu Ala Ser Thr Arg Tyr Pro Pro Pro Ala Val Glu Ser
            1220                1225                1230        
Asp Ala Ala Asp Ile Val Phe Leu Ile Asp Ser Ser Glu Gly Val Arg
        1235                1240                1245            
Pro Asp Gly Phe Ala His Ile Arg Asp Phe Val Ser Arg Ile Val Arg
    1250                1255                1260                
Arg Leu Asn Ile Gly Pro Ser Lys Val Arg Val Gly Val Val Gln Phe
1265                1270                1275                1280
Ser Asn Asp Val Phe Pro Glu Phe Tyr Leu Lys Thr Tyr Arg Ser Gln
                1285                1290                1295    
Ala Pro Val Leu Asp Ala Ile Arg Arg Leu Arg Leu Arg Gly Gly Ser
            1300                1305                1310        
Pro Leu Asn Thr Gly Lys Ala Leu Glu Phe Val Ala Arg Asn Leu Phe
        1315                1320                1325            
Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Pro Gln His Leu
    1330                1335                1340                
Val Leu Val Leu Gly Gly Lys Ser Gln Asp Asp Val Ser Arg Phe Ala
1345                1350                1355                1360
Gln Val Ile Arg Ser Ser Gly Ile Val Ser Leu Gly Val Gly Asp Arg
                1365                1370                1375    
Asn Ile Asp Arg Thr Glu Leu Gln Thr Ile Thr Asn Asp Pro Arg Leu
            1380                1385                1390        
Val Phe Thr Val Arg Glu Phe Arg Glu Leu Pro Asn Ile Glu Glu Arg
        1395                1400                1405            
Ile Met Asn Ser Phe Gly Pro Ser Ala Ala Thr Pro Ala Pro Pro Gly
    1410                1415                1420                
Val Asp Thr Pro Pro Pro Ser Arg Pro Glu Lys Lys Lys Ala Asp Ile
1425                1430                1435                1440
Val Phe Leu Leu Asp Gly Ser Ile Asn Phe Arg Arg Asp Ser Phe Gln
                1445                1450                1455    
Glu Val Leu Arg Phe Val Ser Glu Ile Val Asp Thr Val Tyr Glu Asp
            1460                1465                1470        
Gly Asp Ser Ile Gln Val Gly Leu Val Gln Tyr Asn Ser Asp Pro Thr
        1475                1480                1485            
Asp Glu Phe Phe Leu Lys Asp Phe Ser Thr Lys Arg Gln Ile Ile Asp
    1490                1495                1500                
Ala Ile Asn Lys Val Val Tyr Lys Gly Gly Arg His Ala Asn Thr Lys
1505                1510                1515                1520
Val Gly Leu Glu His Leu Arg Val Asn His Phe Val Pro Glu Ala Gly
                1525                1530                1535    
Ser Arg Leu Asp Gln Arg Val Pro Gln Ile Ala Phe Val Ile Thr Gly
            1540                1545                1550        
Gly Lys Ser Val Glu Asp Ala Gln Asp Val Ser Leu Ala Leu Thr Gln
        1555                1560                1565            
Arg Gly Val Lys Val Phe Ala Val Gly Val Arg Asn Ile Asp Ser Glu
    1570                1575                1580                
Glu Val Gly Lys Ile Ala Ser Asn Ser Ala Thr Ala Phe Arg Val Gly
1585                1590                1595                1600
Asn Val Gln Glu Leu Ser Glu Leu Ser Glu Gln Val Leu Glu Thr Leu
                1605                1610                1615    
His Asp Ala Met His Glu Thr Leu Cys Pro Gly Val Thr Asp Ala Ala
            1620                1625                1630        
Lys Ala Cys Asn Leu Asp Val Ile Leu Gly Phe Asp Gly Ser Arg Asp
        1635                1640                1645            
Gln Asn Val Phe Val Ala Gln Lys Gly Phe Glu Ser Lys Val Asp Ala
    1650                1655                1660                
Ile Leu Asn Arg Ile Ser Gln Met His Arg Val Ser Cys Ser Gly Gly
1665                1670                1675                1680
Arg Ser Pro Thr Val Arg Val Ser Val Val Ala Asn Thr Pro Ser Gly
                1685                1690                1695    
Pro Val Glu Ala Phe Asp Phe Asp Glu Tyr Gln Pro Glu Met Leu Glu
            1700                1705                1710        
Lys Phe Arg Asn Met Arg Ser Gln His Pro Tyr Val Leu Thr Glu Asp
        1715                1720                1725            
Thr Leu Lys Val Tyr Leu Asn Lys Phe Arg Gln Ser Ser Pro Asp Ser
    1730                1735                1740                
Val Lys Val Val Ile His Phe Thr Asp Gly Ala Asp Gly Asp Leu Ala
1745                1750                1755                1760
Asp Leu His Arg Ala Ser Glu Asn Leu Arg Gln Glu Gly Val Arg Ala
                1765                1770                1775    
Leu Ile Leu Val Gly Leu Glu Arg Val Val Asn Leu Glu Arg Leu Met
            1780                1785                1790        
His Leu Glu Phe Gly Arg Gly Phe Met Tyr Asp Arg Pro Leu Arg Leu
        1795                1800                1805            
Asn Leu Leu Asp Leu Asp Tyr Glu Leu Ala Glu Gln Leu Asp Asn Ile
    1810                1815                1820                
Ala Glu Lys Ala Cys Cys Gly Val Pro Cys Lys Cys Ser Gly Gln Arg
1825                1830                1835                1840
Gly Asp Arg Gly Pro Ile Gly Ser Ile Gly Pro Lys Gly Ile Pro Gly
                1845                1850                1855    
Glu Asp Gly Tyr Arg Gly Tyr Pro Gly Asp Glu Gly Gly Pro Gly Glu
            1860                1865                1870        
Arg Gly Pro Pro Gly Val Asn Gly Thr Gln Gly Phe Gln Gly Cys Pro
        1875                1880                1885            
Gly Gln Arg Gly Val Lys Gly Ser Arg Gly Phe Pro Gly Glu Lys Gly
    1890                1895                1900                
Glu Val Gly Glu Ile Gly Leu Asp Gly Leu Asp Gly Glu Asp Gly Asp
1905                1910                1915                1920
Lys Gly Leu Pro Gly Ser Ser Gly Glu Lys Gly Asn Pro Gly Arg Arg
                1925                1930                1935    
Gly Asp Lys Gly Pro Arg Gly Glu Lys Gly Glu Arg Gly Asp Val Gly
            1940                1945                1950        
Ile Arg Gly Asp Pro Gly Asn Pro Gly Gln Asp Ser Gln Glu Arg Gly
        1955                1960                1965            
Pro Lys Gly Glu Thr Gly Asp Leu Gly Pro Met Gly Val Pro Gly Arg
    1970                1975                1980                
Asp Gly Val Pro Gly Gly Pro Gly Glu Thr Gly Lys Asn Gly Gly Phe
1985                1990                1995                2000
Gly Arg Arg Gly Pro Pro Gly Ala Lys Gly Asn Lys Gly Gly Pro Gly
                2005                2010                2015    
Gln Pro Gly Phe Glu Gly Glu Gln Gly Thr Arg Gly Ala Gln Gly Pro
            2020                2025                2030        
Ala Gly Pro Ala Gly Pro Pro Gly Leu Ile Gly Glu Gln Gly Ile Ser
        2035                2040                2045            
Gly Pro Arg Gly Ser Gly Gly Ala Arg Gly Ala Pro Gly Glu Arg Gly
    2050                2055                2060                
Arg Thr Gly Pro Leu Gly Arg Lys Gly Glu Pro Gly Glu Pro Gly Pro
2065                2070                2075                2080
Lys Gly Gly Ile Gly Asn Pro Gly Pro Arg Gly Glu Thr Gly Asp Asp
                2085                2090                2095    
Gly Arg Asp Gly Val Gly Ser Glu Gly Arg Arg Gly Lys Lys Gly Glu
            2100                2105                2110        
Arg Gly Phe Pro Gly Tyr Pro Gly Pro Lys Gly Asn Pro Gly Glu Pro
        2115                2120                2125            
Gly Leu Asn Gly Thr Thr Gly Pro Lys Gly Ile Arg Gly Arg Arg Gly
    2130                2135                2140                
Asn Ser Gly Pro Pro Gly Ile Val Gly Gln Lys Gly Arg Pro Gly Tyr
2145                2150                2155                2160
Pro Gly Pro Ala Gly Pro Arg Gly Asn Arg Gly Asp Ser Ile Asp Gln
                2165                2170                2175    
Cys Ala Leu Ile Gln Ser Ile Lys Asp Lys Cys Pro Cys Cys Tyr Gly
            2180                2185                2190        
Pro Leu Glu Cys Pro Val Phe Pro Thr Glu Leu Ala Phe Ala Leu Asp
        2195                2200                2205            
Thr Ser Glu Gly Val Asn Gln Asp Thr Phe Gly Arg Met Arg Asp Val
    2210                2215                2220                
Val Leu Ser Ile Val Asn Val Leu Thr Ile Ala Glu Ser Asn Cys Pro
2225                2230                2235                2240
Thr Gly Ala Arg Val Ala Val Val Thr Tyr Asn Asn Glu Val Thr Thr
                2245                2250                2255    
Glu Ile Arg Phe Ala Asp Ser Lys Arg Lys Ser Val Leu Leu Asp Lys
            2260                2265                2270        
Ile Lys Asn Leu Gln Val Ala Leu Thr Ser Lys Gln Gln Ser Leu Glu
        2275                2280                2285            
Thr Ala Met Ser Phe Val Ala Arg Asn Thr Phe Lys Arg Val Arg Asn
    2290                2295                2300                
Gly Phe Leu Met Arg Lys Val Ala Val Phe Phe Ser Asn Thr Pro Thr
2305                2310                2315                2320
Arg Ala Ser Pro Gln Leu Arg Glu Ala Val Leu Lys Leu Ser Asp Ala
                2325                2330                2335    
Gly Ile Thr Pro Leu Phe Leu Thr Arg Gln Glu Asp Arg Gln Leu Ile
            2340                2345                2350        
Asn Ala Leu Gln Ile Asn Asn Thr Ala Val Gly His Ala Leu Val Leu
        2355                2360                2365            
Pro Ala Gly Arg Asp Leu Thr Asp Phe Leu Glu Asn Val Leu Thr Cys
    2370                2375                2380                
His Val Cys Leu Asp Ile Cys Asn Ile Asp Pro Ser Cys Gly Phe Gly
2385                2390                2395                2400
Ser Trp Arg Pro Ser Phe Arg Asp Arg Arg Ala Ala Gly Ser Asp Val
                2405                2410                2415    
Asp Ile Asp Met Ala Phe Ile Leu Asp Ser Ala Glu Thr Thr Thr Leu
            2420                2425                2430        
Phe Gln Phe Asn Glu Met Lys Lys Tyr Ile Ala Tyr Leu Val Arg Gln
        2435                2440                2445            
Leu Asp Met Ser Pro Asp Pro Lys Ala Ser Gln His Phe Ala Arg Val
    2450                2455                2460                
Ala Val Val Gln His Ala Pro Ser Glu Ser Val Asp Asn Ala Ser Met
2465                2470                2475                2480
Pro Pro Val Lys Val Glu Phe Ser Leu Thr Asp Tyr Gly Ser Lys Glu
                2485                2490                2495    
Lys Leu Val Asp Phe Leu Ser Arg Gly Met Thr Gln Leu Gln Gly Thr
            2500                2505                2510        
Arg Ala Leu Gly Ser Ala Ile Glu Tyr Thr Ile Glu Asn Val Phe Glu
        2515                2520                2525            
Ser Ala Pro Asn Pro Arg Asp Leu Lys Ile Val Val Leu Met Leu Thr
    2530                2535                2540                
Gly Glu Val Pro Glu Gln Gln Leu Glu Glu Ala Gln Arg Val Ile Leu
2545                2550                2555                2560
Gln Ala Lys Cys Lys Gly Tyr Phe Phe Val Val Leu Gly Ile Gly Arg
                2565                2570                2575    
Lys Val Asn Ile Lys Glu Val Tyr Thr Phe Ala Ser Glu Pro Asn Asp
            2580                2585                2590        
Val Phe Phe Lys Leu Val Asp Lys Ser Thr Glu Leu Asn Glu Glu Pro
        2595                2600                2605            
Leu Met Arg Phe Gly Arg Leu Leu Pro Ser Phe Val Ser Ser Glu Asn
    2610                2615                2620                
Ala Phe Tyr Leu Ser Pro Asp Ile Arg Lys Gln Cys Asp Trp Phe Gln
2625                2630                2635                2640
Gly Asp Gln Pro Thr Lys Asn Leu Val Lys Phe Gly His Lys Gln Val
                2645                2650                2655    
Asn Val Pro Asn Asn Val Thr Ser Ser Pro Thr Ser Asn Pro Val Thr
            2660                2665                2670        
Thr Thr Lys Pro Val Thr Thr Thr Lys Pro Val Thr Thr Thr Thr Lys
        2675                2680                2685            
Pro Val Thr Thr Thr Thr Lys Pro Val Thr Ile Ile Asn Gln Pro Ser
    2690                2695                2700                
Val Lys Pro Ala Ala Ala Lys Pro Ala Pro Ala Lys Pro Val Ala Ala
2705                2710                2715                2720
Lys Pro Val Ala Thr Lys Thr Ala Thr Val Arg Pro Pro Val Ala Val
                2725                2730                2735    
Lys Pro Ala Thr Ala Ala Lys Pro Val Ala Ala Lys Pro Ala Ala Val
            2740                2745                2750        
Arg Pro Pro Ala Ala Ala Ala Lys Pro Val Ala Thr Lys Pro Glu Val
        2755                2760                2765            
Pro Arg Pro Gln Ala Ala Lys Pro Ala Ala Thr Lys Pro Ala Thr Thr
    2770                2775                2780                
Lys Pro Val Val Lys Met Leu Arg Glu Val Gln Val Phe Glu Ile Thr
2785                2790                2795                2800
Glu Asn Ser Ala Lys Leu His Trp Glu Arg Pro Glu Pro Pro Gly Pro
                2805                2810                2815    
Tyr Phe Tyr Asp Leu Thr Val Thr Ser Ala His Asp Gln Ser Leu Val
            2820                2825                2830        
Leu Lys Gln Asn Leu Thr Val Thr Asp Arg Val Ile Gly Gly Leu Leu
        2835                2840                2845            
Ala Gly Gln Thr Tyr His Val Ala Val Val Cys Tyr Leu Arg Ser Gln
    2850                2855                2860                
Val Arg Ala Thr Tyr His Gly Ser Phe Ser Thr Lys Lys Ser Gln Pro
2865                2870                2875                2880
Pro Pro Pro Gln Pro Ala Arg Ser Ala Ser Ser Ser Thr Ile Asn Leu
                2885                2890                2895    
Met Val Ser Thr Glu Pro Leu Ala Leu Thr Glu Thr Asp Ile Cys Lys
            2900                2905                2910        
Leu Pro Lys Asp Glu Gly Thr Cys Arg Asp Phe Ile Leu Lys Trp Tyr
        2915                2920                2925            
Tyr Asp Pro Asn Thr Lys Ser Cys Ala Arg Phe Trp Tyr Gly Gly Cys
    2930                2935                2940                
Gly Gly Asn Glu Asn Lys Phe Gly Ser Gln Lys Glu Cys Glu Lys Val
2945                2950                2955                2960
Cys Ala Pro Val Leu Ala Lys Pro Gly Val Ile Ser Val Met Gly Thr
                2965                2970                2975    


<210> 5608
<211> 3176
<212> PRT
<213> Homo sapiens

<400> 5608
Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe
 1               5                  10                  15      
Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val
            20                  25                  30          
Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp
        35                  40                  45              
Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp
    50                  55                  60                  
Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu
65                  70                  75                  80  
Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr
                85                  90                  95      
Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile
            100                 105                 110         
Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser
        115                 120                 125             
His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln
    130                 135                 140                 
Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu
145                 150                 155                 160 
Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly
                165                 170                 175     
Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro
            180                 185                 190         
Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp
        195                 200                 205             
Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu
    210                 215                 220                 
Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser
225                 230                 235                 240 
Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val
                245                 250                 255     
Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu
            260                 265                 270         
Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp
        275                 280                 285             
Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln
    290                 295                 300                 
Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala
305                 310                 315                 320 
Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg
                325                 330                 335     
Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu
            340                 345                 350         
Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala
        355                 360                 365             
Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala
    370                 375                 380                 
Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe
385                 390                 395                 400 
Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu
                405                 410                 415     
Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro
            420                 425                 430         
Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe
        435                 440                 445             
Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile
    450                 455                 460                 
Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp
465                 470                 475                 480 
Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu
                485                 490                 495     
Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val
            500                 505                 510         
Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala
        515                 520                 525             
Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg
    530                 535                 540                 
Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys
545                 550                 555                 560 
Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser
                565                 570                 575     
Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu
            580                 585                 590         
Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe
        595                 600                 605             
Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu
    610                 615                 620                 
Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg Asp Ile
625                 630                 635                 640 
Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn Phe Pro
                645                 650                 655     
Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp Ile Gly
            660                 665                 670         
Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr Pro Val
        675                 680                 685             
Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile Leu Gly
    690                 695                 700                 
His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn Thr Gly
705                 710                 715                 720 
Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala Gly Gly
                725                 730                 735     
Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu Thr Ala
            740                 745                 750         
Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu Thr Arg
        755                 760                 765             
Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn Lys Ala
    770                 775                 780                 
Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu Met Asp
785                 790                 795                 800 
Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln Pro Leu
                805                 810                 815     
Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala Gln Pro
            820                 825                 830         
Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn Leu
        835                 840                 845             
Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile Asp
    850                 855                 860                 
Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln Tyr
865                 870                 875                 880 
Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser Lys
                885                 890                 895     
Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly Lys
            900                 905                 910         
Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile Phe
        915                 920                 925             
Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe Leu
    930                 935                 940                 
Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro Ala
945                 950                 955                 960 
Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala Lys
                965                 970                 975     
Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala Phe
            980                 985                 990         
Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His Pro Gln
        995                 1000                1005            
Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala Pro Val
    1010                1015                1020                
Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu Gly Val
1025                1030                1035                1040
Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val Val Glu
                1045                1050                1055    
Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val Gln Tyr
            1060                1065                1070        
Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met Asn Lys
        1075                1080                1085            
Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly Gly Pro
    1090                1095                1100                
Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn Ile Leu
1105                1110                1115                1120
Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln Leu Leu
                1125                1130                1135    
Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn Pro Ser
            1140                1145                1150        
Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly Ile Gly
        1155                1160                1165            
Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro Asp Phe
    1170                1175                1180                
Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln Gln Val
1185                1190                1195                1200
Ile Ser Glu Arg Val Thr Gln Leu Thr Arg Glu Glu Leu Ser Arg Leu
                1205                1210                1215    
Gln Pro Val Leu Gln Pro Leu Pro Ser Pro Gly Val Gly Gly Lys Arg
            1220                1225                1230        
Asp Val Val Phe Leu Ile Asp Gly Ser Gln Ser Ala Gly Pro Glu Phe
        1235                1240                1245            
Gln Tyr Val Arg Thr Leu Ile Glu Arg Leu Val Asp Tyr Leu Asp Val
    1250                1255                1260                
Gly Phe Asp Thr Thr Arg Val Ala Val Ile Gln Phe Ser Asp Asp Pro
1265                1270                1275                1280
Lys Ala Glu Phe Leu Leu Asn Ala His Ser Ser Lys Asp Glu Val Gln
                1285                1290                1295    
Asn Ala Val Gln Arg Leu Arg Pro Lys Gly Gly Arg Gln Ile Asn Val
            1300                1305                1310        
Gly Asn Ala Leu Glu Tyr Val Ser Arg Asn Ile Phe Lys Arg Pro Leu
        1315                1320                1325            
Gly Ser Arg Ile Glu Glu Gly Val Pro Gln Phe Leu Val Leu Ile Ser
    1330                1335                1340                
Ser Gly Lys Ser Asp Asp Glu Val Val Val Pro Ala Val Glu Leu Lys
1345                1350                1355                1360
Gln Phe Gly Val Ala Pro Phe Thr Ile Ala Arg Asn Ala Asp Gln Glu
                1365                1370                1375    
Glu Leu Val Lys Ile Ser Leu Ser Pro Glu Tyr Val Phe Ser Val Ser
            1380                1385                1390        
Thr Phe Arg Glu Leu Pro Ser Leu Glu Gln Lys Leu Leu Thr Pro Ile
        1395                1400                1405            
Thr Thr Leu Thr Ser Glu Gln Ile Gln Lys Leu Leu Ala Ser Thr Arg
    1410                1415                1420                
Tyr Pro Pro Pro Ala Val Glu Ser Asp Ala Ala Asp Ile Val Phe Leu
1425                1430                1435                1440
Ile Asp Ser Ser Glu Gly Val Arg Pro Asp Gly Phe Ala His Ile Arg
                1445                1450                1455    
Asp Phe Val Ser Arg Ile Val Arg Arg Leu Asn Ile Gly Pro Ser Lys
            1460                1465                1470        
Val Arg Val Gly Val Val Gln Phe Ser Asn Asp Val Phe Pro Glu Phe
        1475                1480                1485            
Tyr Leu Lys Thr Tyr Arg Ser Gln Ala Pro Val Leu Asp Ala Ile Arg
    1490                1495                1500                
Arg Leu Arg Leu Arg Gly Gly Ser Pro Leu Asn Thr Gly Lys Ala Leu
1505                1510                1515                1520
Glu Phe Val Ala Arg Asn Leu Phe Val Lys Ser Ala Gly Ser Arg Ile
                1525                1530                1535    
Glu Asp Gly Val Pro Gln His Leu Val Leu Val Leu Gly Gly Lys Ser
            1540                1545                1550        
Gln Asp Asp Val Ser Arg Phe Ala Gln Val Ile Arg Ser Ser Gly Ile
        1555                1560                1565            
Val Ser Leu Gly Val Gly Asp Arg Asn Ile Asp Arg Thr Glu Leu Gln
    1570                1575                1580                
Thr Ile Thr Asn Asp Pro Arg Leu Val Phe Thr Val Arg Glu Phe Arg
1585                1590                1595                1600
Glu Leu Pro Asn Ile Glu Glu Arg Ile Met Asn Ser Phe Gly Pro Ser
                1605                1610                1615    
Ala Ala Thr Pro Ala Pro Pro Gly Val Asp Thr Pro Pro Pro Ser Arg
            1620                1625                1630        
Pro Glu Lys Lys Lys Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ile
        1635                1640                1645            
Asn Phe Arg Arg Asp Ser Phe Gln Glu Val Leu Arg Phe Val Ser Glu
    1650                1655                1660                
Ile Val Asp Thr Val Tyr Glu Asp Gly Asp Ser Ile Gln Val Gly Leu
1665                1670                1675                1680
Val Gln Tyr Asn Ser Asp Pro Thr Asp Glu Phe Phe Leu Lys Asp Phe
                1685                1690                1695    
Ser Thr Lys Arg Gln Ile Ile Asp Ala Ile Asn Lys Val Val Tyr Lys
            1700                1705                1710        
Gly Gly Arg His Ala Asn Thr Lys Val Gly Leu Glu His Leu Arg Val
        1715                1720                1725            
Asn His Phe Val Pro Glu Ala Gly Ser Arg Leu Asp Gln Arg Val Pro
    1730                1735                1740                
Gln Ile Ala Phe Val Ile Thr Gly Gly Lys Ser Val Glu Asp Ala Gln
1745                1750                1755                1760
Asp Val Ser Leu Ala Leu Thr Gln Arg Gly Val Lys Val Phe Ala Val
                1765                1770                1775    
Gly Val Arg Asn Ile Asp Ser Glu Glu Val Gly Lys Ile Ala Ser Asn
            1780                1785                1790        
Ser Ala Thr Ala Phe Arg Val Gly Asn Val Gln Glu Leu Ser Glu Leu
        1795                1800                1805            
Ser Glu Gln Val Leu Glu Thr Leu His Asp Ala Met His Glu Thr Leu
    1810                1815                1820                
Cys Pro Gly Val Thr Asp Ala Ala Lys Ala Cys Asn Leu Asp Val Ile
1825                1830                1835                1840
Leu Gly Phe Asp Gly Ser Arg Asp Gln Asn Val Phe Val Ala Gln Lys
                1845                1850                1855    
Gly Phe Glu Ser Lys Val Asp Ala Ile Leu Asn Arg Ile Ser Gln Met
            1860                1865                1870        
His Arg Val Ser Cys Ser Gly Gly Arg Ser Pro Thr Val Arg Val Ser
        1875                1880                1885            
Val Val Ala Asn Thr Pro Ser Gly Pro Val Glu Ala Phe Asp Phe Asp
    1890                1895                1900                
Glu Tyr Gln Pro Glu Met Leu Glu Lys Phe Arg Asn Met Arg Ser Gln
1905                1910                1915                1920
His Pro Tyr Val Leu Thr Glu Asp Thr Leu Lys Val Tyr Leu Asn Lys
                1925                1930                1935    
Phe Arg Gln Ser Ser Pro Asp Ser Val Lys Val Val Ile His Phe Thr
            1940                1945                1950        
Asp Gly Ala Asp Gly Asp Leu Ala Asp Leu His Arg Ala Ser Glu Asn
        1955                1960                1965            
Leu Arg Gln Glu Gly Val Arg Ala Leu Ile Leu Val Gly Leu Glu Arg
    1970                1975                1980                
Val Val Asn Leu Glu Arg Leu Met His Leu Glu Phe Gly Arg Gly Phe
1985                1990                1995                2000
Met Tyr Asp Arg Pro Leu Arg Leu Asn Leu Leu Asp Leu Asp Tyr Glu
                2005                2010                2015    
Leu Ala Glu Gln Leu Asp Asn Ile Ala Glu Lys Ala Cys Cys Gly Val
            2020                2025                2030        
Pro Cys Lys Cys Ser Gly Gln Arg Gly Asp Arg Gly Pro Ile Gly Ser
        2035                2040                2045            
Ile Gly Pro Lys Gly Ile Pro Gly Glu Asp Gly Tyr Arg Gly Tyr Pro
    2050                2055                2060                
Gly Asp Glu Gly Gly Pro Gly Glu Arg Gly Pro Pro Gly Val Asn Gly
2065                2070                2075                2080
Thr Gln Gly Phe Gln Gly Cys Pro Gly Gln Arg Gly Val Lys Gly Ser
                2085                2090                2095    
Arg Gly Phe Pro Gly Glu Lys Gly Glu Val Gly Glu Ile Gly Leu Asp
            2100                2105                2110        
Gly Leu Asp Gly Glu Asp Gly Asp Lys Gly Leu Pro Gly Ser Ser Gly
        2115                2120                2125            
Glu Lys Gly Asn Pro Gly Arg Arg Gly Asp Lys Gly Pro Arg Gly Glu
    2130                2135                2140                
Lys Gly Glu Arg Gly Asp Val Gly Ile Arg Gly Asp Pro Gly Asn Pro
2145                2150                2155                2160
Gly Gln Asp Ser Gln Glu Arg Gly Pro Lys Gly Glu Thr Gly Asp Leu
                2165                2170                2175    
Gly Pro Met Gly Val Pro Gly Arg Asp Gly Val Pro Gly Gly Pro Gly
            2180                2185                2190        
Glu Thr Gly Lys Asn Gly Gly Phe Gly Arg Arg Gly Pro Pro Gly Ala
        2195                2200                2205            
Lys Gly Asn Lys Gly Gly Pro Gly Gln Pro Gly Phe Glu Gly Glu Gln
    2210                2215                2220                
Gly Thr Arg Gly Ala Gln Gly Pro Ala Gly Pro Ala Gly Pro Pro Gly
2225                2230                2235                2240
Leu Ile Gly Glu Gln Gly Ile Ser Gly Pro Arg Gly Ser Gly Gly Ala
                2245                2250                2255    
Arg Gly Ala Pro Gly Glu Arg Gly Arg Thr Gly Pro Leu Gly Arg Lys
            2260                2265                2270        
Gly Glu Pro Gly Glu Pro Gly Pro Lys Gly Gly Ile Gly Asn Pro Gly
        2275                2280                2285            
Pro Arg Gly Glu Thr Gly Asp Asp Gly Arg Asp Gly Val Gly Ser Glu
    2290                2295                2300                
Gly Arg Arg Gly Lys Lys Gly Glu Arg Gly Phe Pro Gly Tyr Pro Gly
2305                2310                2315                2320
Pro Lys Gly Asn Pro Gly Glu Pro Gly Leu Asn Gly Thr Thr Gly Pro
                2325                2330                2335    
Lys Gly Ile Arg Gly Arg Arg Gly Asn Ser Gly Pro Pro Gly Ile Val
            2340                2345                2350        
Gly Gln Lys Gly Arg Pro Gly Tyr Pro Gly Pro Ala Gly Pro Arg Gly
        2355                2360                2365            
Asn Arg Gly Asp Ser Ile Asp Gln Cys Ala Leu Ile Gln Ser Ile Lys
    2370                2375                2380                
Asp Lys Cys Pro Cys Cys Tyr Gly Pro Leu Glu Cys Pro Val Phe Pro
2385                2390                2395                2400
Thr Glu Leu Ala Phe Ala Leu Asp Thr Ser Glu Gly Val Asn Gln Asp
                2405                2410                2415    
Thr Phe Gly Arg Met Arg Asp Val Val Leu Ser Ile Val Asn Val Leu
            2420                2425                2430        
Thr Ile Ala Glu Ser Asn Cys Pro Thr Gly Ala Arg Val Ala Val Val
        2435                2440                2445            
Thr Tyr Asn Asn Glu Val Thr Thr Glu Ile Arg Phe Ala Asp Ser Lys
    2450                2455                2460                
Arg Lys Ser Val Leu Leu Asp Lys Ile Lys Asn Leu Gln Val Ala Leu
2465                2470                2475                2480
Thr Ser Lys Gln Gln Ser Leu Glu Thr Ala Met Ser Phe Val Ala Arg
                2485                2490                2495    
Asn Thr Phe Lys Arg Val Arg Asn Gly Phe Leu Met Arg Lys Val Ala
            2500                2505                2510        
Val Phe Phe Ser Asn Thr Pro Thr Arg Ala Ser Pro Gln Leu Arg Glu
        2515                2520                2525            
Ala Val Leu Lys Leu Ser Asp Ala Gly Ile Thr Pro Leu Phe Leu Thr
    2530                2535                2540                
Arg Gln Glu Asp Arg Gln Leu Ile Asn Ala Leu Gln Ile Asn Asn Thr
2545                2550                2555                2560
Ala Val Gly His Ala Leu Val Leu Pro Ala Gly Arg Asp Leu Thr Asp
                2565                2570                2575    
Phe Leu Glu Asn Val Leu Thr Cys His Val Cys Leu Asp Ile Cys Asn
            2580                2585                2590        
Ile Asp Pro Ser Cys Gly Phe Gly Ser Trp Arg Pro Ser Phe Arg Asp
        2595                2600                2605            
Arg Arg Ala Ala Gly Ser Asp Val Asp Ile Asp Met Ala Phe Ile Leu
    2610                2615                2620                
Asp Ser Ala Glu Thr Thr Thr Leu Phe Gln Phe Asn Glu Met Lys Lys
2625                2630                2635                2640
Tyr Ile Ala Tyr Leu Val Arg Gln Leu Asp Met Ser Pro Asp Pro Lys
                2645                2650                2655    
Ala Ser Gln His Phe Ala Arg Val Ala Val Val Gln His Ala Pro Ser
            2660                2665                2670        
Glu Ser Val Asp Asn Ala Ser Met Pro Pro Val Lys Val Glu Phe Ser
        2675                2680                2685            
Leu Thr Asp Tyr Gly Ser Lys Glu Lys Leu Val Asp Phe Leu Ser Arg
    2690                2695                2700                
Gly Met Thr Gln Leu Gln Gly Thr Arg Ala Leu Gly Ser Ala Ile Glu
2705                2710                2715                2720
Tyr Thr Ile Glu Asn Val Phe Glu Ser Ala Pro Asn Pro Arg Asp Leu
                2725                2730                2735    
Lys Ile Val Val Leu Met Leu Thr Gly Glu Val Pro Glu Gln Gln Leu
            2740                2745                2750        
Glu Glu Ala Gln Arg Val Ile Leu Gln Ala Lys Cys Lys Gly Tyr Phe
        2755                2760                2765            
Phe Val Val Leu Gly Ile Gly Arg Lys Val Asn Ile Lys Glu Val Tyr
    2770                2775                2780                
Thr Phe Ala Ser Glu Pro Asn Asp Val Phe Phe Lys Leu Val Asp Lys
2785                2790                2795                2800
Ser Thr Glu Leu Asn Glu Glu Pro Leu Met Arg Phe Gly Arg Leu Leu
                2805                2810                2815    
Pro Ser Phe Val Ser Ser Glu Asn Ala Phe Tyr Leu Ser Pro Asp Ile
            2820                2825                2830        
Arg Lys Gln Cys Asp Trp Phe Gln Gly Asp Gln Pro Thr Lys Asn Leu
        2835                2840                2845            
Val Lys Phe Gly His Lys Gln Val Asn Val Pro Asn Asn Val Thr Ser
    2850                2855                2860                
Ser Pro Thr Ser Asn Pro Val Thr Thr Thr Lys Pro Val Thr Thr Thr
2865                2870                2875                2880
Lys Pro Val Thr Thr Thr Thr Lys Pro Val Thr Thr Thr Thr Lys Pro
                2885                2890                2895    
Val Thr Ile Ile Asn Gln Pro Ser Val Lys Pro Ala Ala Ala Lys Pro
            2900                2905                2910        
Ala Pro Ala Lys Pro Val Ala Ala Lys Pro Val Ala Thr Lys Thr Ala
        2915                2920                2925            
Thr Val Arg Pro Pro Val Ala Val Lys Pro Ala Thr Ala Ala Lys Pro
    2930                2935                2940                
Val Ala Ala Lys Pro Ala Ala Val Arg Pro Pro Ala Ala Ala Ala Lys
2945                2950                2955                2960
Pro Val Ala Thr Lys Pro Glu Val Pro Arg Pro Gln Ala Ala Lys Pro
                2965                2970                2975    
Ala Ala Thr Lys Pro Ala Thr Thr Lys Pro Val Val Lys Met Leu Arg
            2980                2985                2990        
Glu Val Gln Val Phe Glu Ile Thr Glu Asn Ser Ala Lys Leu His Trp
        2995                3000                3005            
Glu Arg Pro Glu Pro Pro Gly Pro Tyr Phe Tyr Asp Leu Thr Val Thr
    3010                3015                3020                
Ser Ala His Asp Gln Ser Leu Val Leu Lys Gln Asn Leu Thr Val Thr
3025                3030                3035                3040
Asp Arg Val Ile Gly Gly Leu Leu Ala Gly Gln Thr Tyr His Val Ala
                3045                3050                3055    
Val Val Cys Tyr Leu Arg Ser Gln Val Arg Ala Thr Tyr His Gly Ser
            3060                3065                3070        
Phe Ser Thr Lys Lys Ser Gln Pro Pro Pro Pro Gln Pro Ala Arg Ser
        3075                3080                3085            
Ala Ser Ser Ser Thr Ile Asn Leu Met Val Ser Thr Glu Pro Leu Ala
    3090                3095                3100                
Leu Thr Glu Thr Asp Ile Cys Lys Leu Pro Lys Asp Glu Gly Thr Cys
3105                3110                3115                3120
Arg Asp Phe Ile Leu Lys Trp Tyr Tyr Asp Pro Asn Thr Lys Ser Cys
                3125                3130                3135    
Ala Arg Phe Trp Tyr Gly Gly Cys Gly Gly Asn Glu Asn Lys Phe Gly
            3140                3145                3150        
Ser Gln Lys Glu Cys Glu Lys Val Cys Ala Pro Val Leu Ala Lys Pro
        3155                3160                3165            
Gly Val Ile Ser Val Met Gly Thr
    3170                3175    


<210> 5609
<211> 2971
<212> PRT
<213> Homo sapiens

<400> 5609
Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe
 1               5                  10                  15      
Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Ala
            20                  25                  30          
Gln Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr
        35                  40                  45              
Gly Ser Val Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu
    50                  55                  60                  
Glu Lys Leu Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln
65                  70                  75                  80  
Phe Ser Asp Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr
                85                  90                  95      
Lys Ala Gln Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly
            100                 105                 110         
Glu Leu Ala Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His
        115                 120                 125             
Phe Thr Arg Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val
    130                 135                 140                 
Leu Val Leu Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly
145                 150                 155                 160 
Val Val Ala Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala
                165                 170                 175     
Gln Ala Ala Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn
            180                 185                 190         
Leu Val Phe Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu
        195                 200                 205             
Lys Leu Leu Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu
    210                 215                 220                 
Lys Pro Pro Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp
225                 230                 235                 240 
Ile Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe
                245                 250                 255     
Asn Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile
            260                 265                 270         
Gly Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val
        275                 280                 285             
Arg Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile
    290                 295                 300                 
Thr Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr
305                 310                 315                 320 
Gly Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala
                325                 330                 335     
Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr
            340                 345                 350         
Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys
        355                 360                 365             
Arg Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln
    370                 375                 380                 
Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro
385                 390                 395                 400 
Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu
                405                 410                 415     
Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys
            420                 425                 430         
Arg Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr
        435                 440                 445             
Asn Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu
    450                 455                 460                 
Asp Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp
465                 470                 475                 480 
Thr Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp
                485                 490                 495     
Ile Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu
            500                 505                 510         
Asn Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu
        515                 520                 525             
Ala Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu
    530                 535                 540                 
Leu Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala
545                 550                 555                 560 
Leu Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala
                565                 570                 575     
Asn Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr
            580                 585                 590         
Leu Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile
        595                 600                 605             
Gln Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu
    610                 615                 620                 
Ala Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser
625                 630                 635                 640 
Ala Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys
                645                 650                 655     
Ile Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val
            660                 665                 670         
Ala Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His
        675                 680                 685             
Gln Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys
    690                 695                 700                 
Thr Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg
705                 710                 715                 720 
Tyr Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu
                725                 730                 735     
Gln Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp
            740                 745                 750         
Gly Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe
        755                 760                 765             
Gln Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser
    770                 775                 780                 
Pro Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu
785                 790                 795                 800 
His Pro Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro
                805                 810                 815     
Ala Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser
            820                 825                 830         
Glu Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg
        835                 840                 845             
Val Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val
    850                 855                 860                 
Val Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr
865                 870                 875                 880 
Met Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu
                885                 890                 895     
Gly Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg
            900                 905                 910         
Asn Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro
        915                 920                 925             
Gln Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg
    930                 935                 940                 
Asn Pro Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile
945                 950                 955                 960 
Gly Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile
                965                 970                 975     
Pro Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val
            980                 985                 990         
Gln Gln Val Ile Ser Glu Arg Val Thr Gln Leu Thr Arg Glu Glu Leu
        995                 1000                1005            
Ser Arg Leu Gln Pro Val Leu Gln Pro Leu Pro Ser Pro Gly Val Gly
    1010                1015                1020                
Gly Lys Arg Asp Val Val Phe Leu Ile Asp Gly Ser Gln Ser Ala Gly
1025                1030                1035                1040
Pro Glu Phe Gln Tyr Val Arg Thr Leu Ile Glu Arg Leu Val Asp Tyr
                1045                1050                1055    
Leu Asp Val Gly Phe Asp Thr Thr Arg Val Ala Val Ile Gln Phe Ser
            1060                1065                1070        
Asp Asp Pro Lys Ala Glu Phe Leu Leu Asn Ala His Ser Ser Lys Asp
        1075                1080                1085            
Glu Val Gln Asn Ala Val Gln Arg Leu Arg Pro Lys Gly Gly Arg Gln
    1090                1095                1100                
Ile Asn Val Gly Asn Ala Leu Glu Tyr Val Ser Arg Asn Ile Phe Lys
1105                1110                1115                1120
Arg Pro Leu Gly Ser Arg Ile Glu Glu Gly Val Pro Gln Phe Leu Val
                1125                1130                1135    
Leu Ile Ser Ser Gly Lys Ser Asp Asp Glu Val Val Val Pro Ala Val
            1140                1145                1150        
Glu Leu Lys Gln Phe Gly Val Ala Pro Phe Thr Ile Ala Arg Asn Ala
        1155                1160                1165            
Asp Gln Glu Glu Leu Val Lys Ile Ser Leu Ser Pro Glu Tyr Val Phe
    1170                1175                1180                
Ser Val Ser Thr Phe Arg Glu Leu Pro Ser Leu Glu Gln Lys Leu Leu
1185                1190                1195                1200
Thr Pro Ile Thr Thr Leu Thr Ser Glu Gln Ile Gln Lys Leu Leu Ala
                1205                1210                1215    
Ser Thr Arg Tyr Pro Pro Pro Ala Val Glu Ser Asp Ala Ala Asp Ile
            1220                1225                1230        
Val Phe Leu Ile Asp Ser Ser Glu Gly Val Arg Pro Asp Gly Phe Ala
        1235                1240                1245            
His Ile Arg Asp Phe Val Ser Arg Ile Val Arg Arg Leu Asn Ile Gly
    1250                1255                1260                
Pro Ser Lys Val Arg Val Gly Val Val Gln Phe Ser Asn Asp Val Phe
1265                1270                1275                1280
Pro Glu Phe Tyr Leu Lys Thr Tyr Arg Ser Gln Ala Pro Val Leu Asp
                1285                1290                1295    
Ala Ile Arg Arg Leu Arg Leu Arg Gly Gly Ser Pro Leu Asn Thr Gly
            1300                1305                1310        
Lys Ala Leu Glu Phe Val Ala Arg Asn Leu Phe Val Lys Ser Ala Gly
        1315                1320                1325            
Ser Arg Ile Glu Asp Gly Val Pro Gln His Leu Val Leu Val Leu Gly
    1330                1335                1340                
Gly Lys Ser Gln Asp Asp Val Ser Arg Phe Ala Gln Val Ile Arg Ser
1345                1350                1355                1360
Ser Gly Ile Val Ser Leu Gly Val Gly Asp Arg Asn Ile Asp Arg Thr
                1365                1370                1375    
Glu Leu Gln Thr Ile Thr Asn Asp Pro Arg Leu Val Phe Thr Val Arg
            1380                1385                1390        
Glu Phe Arg Glu Leu Pro Asn Ile Glu Glu Arg Ile Met Asn Ser Phe
        1395                1400                1405            
Gly Pro Ser Ala Ala Thr Pro Ala Pro Pro Gly Val Asp Thr Pro Pro
    1410                1415                1420                
Pro Ser Arg Pro Glu Lys Lys Lys Ala Asp Ile Val Phe Leu Leu Asp
1425                1430                1435                1440
Gly Ser Ile Asn Phe Arg Arg Asp Ser Phe Gln Glu Val Leu Arg Phe
                1445                1450                1455    
Val Ser Glu Ile Val Asp Thr Val Tyr Glu Asp Gly Asp Ser Ile Gln
            1460                1465                1470        
Val Gly Leu Val Gln Tyr Asn Ser Asp Pro Thr Asp Glu Phe Phe Leu
        1475                1480                1485            
Lys Asp Phe Ser Thr Lys Arg Gln Ile Ile Asp Ala Ile Asn Lys Val
    1490                1495                1500                
Val Tyr Lys Gly Gly Arg His Ala Asn Thr Lys Val Gly Leu Glu His
1505                1510                1515                1520
Leu Arg Val Asn His Phe Val Pro Glu Ala Gly Ser Arg Leu Asp Gln
                1525                1530                1535    
Arg Val Pro Gln Ile Ala Phe Val Ile Thr Gly Gly Lys Ser Val Glu
            1540                1545                1550        
Asp Ala Gln Asp Val Ser Leu Ala Leu Thr Gln Arg Gly Val Lys Val
        1555                1560                1565            
Phe Ala Val Gly Val Arg Asn Ile Asp Ser Glu Glu Val Gly Lys Ile
    1570                1575                1580                
Ala Ser Asn Ser Ala Thr Ala Phe Arg Val Gly Asn Val Gln Glu Leu
1585                1590                1595                1600
Ser Glu Leu Ser Glu Gln Val Leu Glu Thr Leu His Asp Ala Met His
                1605                1610                1615    
Glu Thr Leu Cys Pro Gly Val Thr Asp Ala Ala Lys Ala Cys Asn Leu
            1620                1625                1630        
Asp Val Ile Leu Gly Phe Asp Gly Ser Arg Asp Gln Asn Val Phe Val
        1635                1640                1645            
Ala Gln Lys Gly Phe Glu Ser Lys Val Asp Ala Ile Leu Asn Arg Ile
    1650                1655                1660                
Ser Gln Met His Arg Val Ser Cys Ser Gly Gly Arg Ser Pro Thr Val
1665                1670                1675                1680
Arg Val Ser Val Val Ala Asn Thr Pro Ser Gly Pro Val Glu Ala Phe
                1685                1690                1695    
Asp Phe Asp Glu Tyr Gln Pro Glu Met Leu Glu Lys Phe Arg Asn Met
            1700                1705                1710        
Arg Ser Gln His Pro Tyr Val Leu Thr Glu Asp Thr Leu Lys Val Tyr
        1715                1720                1725            
Leu Asn Lys Phe Arg Gln Ser Ser Pro Asp Ser Val Lys Val Val Ile
    1730                1735                1740                
His Phe Thr Asp Gly Ala Asp Gly Asp Leu Ala Asp Leu His Arg Ala
1745                1750                1755                1760
Ser Glu Asn Leu Arg Gln Glu Gly Val Arg Ala Leu Ile Leu Val Gly
                1765                1770                1775    
Leu Glu Arg Val Val Asn Leu Glu Arg Leu Met His Leu Glu Phe Gly
            1780                1785                1790        
Arg Gly Phe Met Tyr Asp Arg Pro Leu Arg Leu Asn Leu Leu Asp Leu
        1795                1800                1805            
Asp Tyr Glu Leu Ala Glu Gln Leu Asp Asn Ile Ala Glu Lys Ala Cys
    1810                1815                1820                
Cys Gly Val Pro Cys Lys Cys Ser Gly Gln Arg Gly Asp Arg Gly Pro
1825                1830                1835                1840
Ile Gly Ser Ile Gly Pro Lys Gly Ile Pro Gly Glu Asp Gly Tyr Arg
                1845                1850                1855    
Gly Tyr Pro Gly Asp Glu Gly Gly Pro Gly Glu Arg Gly Pro Pro Gly
            1860                1865                1870        
Val Asn Gly Thr Gln Gly Phe Gln Gly Cys Pro Gly Gln Arg Gly Val
        1875                1880                1885            
Lys Gly Ser Arg Gly Phe Pro Gly Glu Lys Gly Glu Val Gly Glu Ile
    1890                1895                1900                
Gly Leu Asp Gly Leu Asp Gly Glu Asp Gly Asp Lys Gly Leu Pro Gly
1905                1910                1915                1920
Ser Ser Gly Glu Lys Gly Asn Pro Gly Arg Arg Gly Asp Lys Gly Pro
                1925                1930                1935    
Arg Gly Glu Lys Gly Glu Arg Gly Asp Val Gly Ile Arg Gly Asp Pro
            1940                1945                1950        
Gly Asn Pro Gly Gln Asp Ser Gln Glu Arg Gly Pro Lys Gly Glu Thr
        1955                1960                1965            
Gly Asp Leu Gly Pro Met Gly Val Pro Gly Arg Asp Gly Val Pro Gly
    1970                1975                1980                
Gly Pro Gly Glu Thr Gly Lys Asn Gly Gly Phe Gly Arg Arg Gly Pro
1985                1990                1995                2000
Pro Gly Ala Lys Gly Asn Lys Gly Gly Pro Gly Gln Pro Gly Phe Glu
                2005                2010                2015    
Gly Glu Gln Gly Thr Arg Gly Ala Gln Gly Pro Ala Gly Pro Ala Gly
            2020                2025                2030        
Pro Pro Gly Leu Ile Gly Glu Gln Gly Ile Ser Gly Pro Arg Gly Ser
        2035                2040                2045            
Gly Gly Ala Arg Gly Ala Pro Gly Glu Arg Gly Arg Thr Gly Pro Leu
    2050                2055                2060                
Gly Arg Lys Gly Glu Pro Gly Glu Pro Gly Pro Lys Gly Gly Ile Gly
2065                2070                2075                2080
Asn Pro Gly Pro Arg Gly Glu Thr Gly Asp Asp Gly Arg Asp Gly Val
                2085                2090                2095    
Gly Ser Glu Gly Arg Arg Gly Lys Lys Gly Glu Arg Gly Phe Pro Gly
            2100                2105                2110        
Tyr Pro Gly Pro Lys Gly Asn Pro Gly Glu Pro Gly Leu Asn Gly Thr
        2115                2120                2125            
Thr Gly Pro Lys Gly Ile Arg Gly Arg Arg Gly Asn Ser Gly Pro Pro
    2130                2135                2140                
Gly Ile Val Gly Gln Lys Gly Arg Pro Gly Tyr Pro Gly Pro Ala Gly
2145                2150                2155                2160
Pro Arg Gly Asn Arg Gly Asp Ser Ile Asp Gln Cys Ala Leu Ile Gln
                2165                2170                2175    
Ser Ile Lys Asp Lys Cys Pro Cys Cys Tyr Gly Pro Leu Glu Cys Pro
            2180                2185                2190        
Val Phe Pro Thr Glu Leu Ala Phe Ala Leu Asp Thr Ser Glu Gly Val
        2195                2200                2205            
Asn Gln Asp Thr Phe Gly Arg Met Arg Asp Val Val Leu Ser Ile Val
    2210                2215                2220                
Asn Val Leu Thr Ile Ala Glu Ser Asn Cys Pro Thr Gly Ala Arg Val
2225                2230                2235                2240
Ala Val Val Thr Tyr Asn Asn Glu Val Thr Thr Glu Ile Arg Phe Ala
                2245                2250                2255    
Asp Ser Lys Arg Lys Ser Val Leu Leu Asp Lys Ile Lys Asn Leu Gln
            2260                2265                2270        
Val Ala Leu Thr Ser Lys Gln Gln Ser Leu Glu Thr Ala Met Ser Phe
        2275                2280                2285            
Val Ala Arg Asn Thr Phe Lys Arg Val Arg Asn Gly Phe Leu Met Arg
    2290                2295                2300                
Lys Val Ala Val Phe Phe Ser Asn Thr Pro Thr Arg Ala Ser Pro Gln
2305                2310                2315                2320
Leu Arg Glu Ala Val Leu Lys Leu Ser Asp Ala Gly Ile Thr Pro Leu
                2325                2330                2335    
Phe Leu Thr Arg Gln Glu Asp Arg Gln Leu Ile Asn Ala Leu Gln Ile
            2340                2345                2350        
Asn Asn Thr Ala Val Gly His Ala Leu Val Leu Pro Ala Gly Arg Asp
        2355                2360                2365            
Leu Thr Asp Phe Leu Glu Asn Val Leu Thr Cys His Val Cys Leu Asp
    2370                2375                2380                
Ile Cys Asn Ile Asp Pro Ser Cys Gly Phe Gly Ser Trp Arg Pro Ser
2385                2390                2395                2400
Phe Arg Asp Arg Arg Ala Ala Gly Ser Asp Val Asp Ile Asp Met Ala
                2405                2410                2415    
Phe Ile Leu Asp Ser Ala Glu Thr Thr Thr Leu Phe Gln Phe Asn Glu
            2420                2425                2430        
Met Lys Lys Tyr Ile Ala Tyr Leu Val Arg Gln Leu Asp Met Ser Pro
        2435                2440                2445            
Asp Pro Lys Ala Ser Gln His Phe Ala Arg Val Ala Val Val Gln His
    2450                2455                2460                
Ala Pro Ser Glu Ser Val Asp Asn Ala Ser Met Pro Pro Val Lys Val
2465                2470                2475                2480
Glu Phe Ser Leu Thr Asp Tyr Gly Ser Lys Glu Lys Leu Val Asp Phe
                2485                2490                2495    
Leu Ser Arg Gly Met Thr Gln Leu Gln Gly Thr Arg Ala Leu Gly Ser
            2500                2505                2510        
Ala Ile Glu Tyr Thr Ile Glu Asn Val Phe Glu Ser Ala Pro Asn Pro
        2515                2520                2525            
Arg Asp Leu Lys Ile Val Val Leu Met Leu Thr Gly Glu Val Pro Glu
    2530                2535                2540                
Gln Gln Leu Glu Glu Ala Gln Arg Val Ile Leu Gln Ala Lys Cys Lys
2545                2550                2555                2560
Gly Tyr Phe Phe Val Val Leu Gly Ile Gly Arg Lys Val Asn Ile Lys
                2565                2570                2575    
Glu Val Tyr Thr Phe Ala Ser Glu Pro Asn Asp Val Phe Phe Lys Leu
            2580                2585                2590        
Val Asp Lys Ser Thr Glu Leu Asn Glu Glu Pro Leu Met Arg Phe Gly
        2595                2600                2605            
Arg Leu Leu Pro Ser Phe Val Ser Ser Glu Asn Ala Phe Tyr Leu Ser
    2610                2615                2620                
Pro Asp Ile Arg Lys Gln Cys Asp Trp Phe Gln Gly Asp Gln Pro Thr
2625                2630                2635                2640
Lys Asn Leu Val Lys Phe Gly His Lys Gln Val Asn Val Pro Asn Asn
                2645                2650                2655    
Val Thr Ser Ser Pro Thr Ser Asn Pro Val Thr Thr Thr Lys Pro Val
            2660                2665                2670        
Thr Thr Thr Lys Pro Val Thr Thr Thr Thr Lys Pro Val Thr Thr Thr
        2675                2680                2685            
Thr Lys Pro Val Thr Ile Ile Asn Gln Pro Ser Val Lys Pro Ala Ala
    2690                2695                2700                
Ala Lys Pro Ala Pro Ala Lys Pro Val Ala Ala Lys Pro Val Ala Thr
2705                2710                2715                2720
Lys Thr Ala Thr Val Arg Pro Pro Val Ala Val Lys Pro Ala Thr Ala
                2725                2730                2735    
Ala Lys Pro Val Ala Ala Lys Pro Ala Ala Val Arg Pro Pro Ala Ala
            2740                2745                2750        
Ala Ala Lys Pro Val Ala Thr Lys Pro Glu Val Pro Arg Pro Gln Ala
        2755                2760                2765            
Ala Lys Pro Ala Ala Thr Lys Pro Ala Thr Thr Lys Pro Val Val Lys
    2770                2775                2780                
Met Leu Arg Glu Val Gln Val Phe Glu Ile Thr Glu Asn Ser Ala Lys
2785                2790                2795                2800
Leu His Trp Glu Arg Pro Glu Pro Pro Gly Pro Tyr Phe Tyr Asp Leu
                2805                2810                2815    
Thr Val Thr Ser Ala His Asp Gln Ser Leu Val Leu Lys Gln Asn Leu
            2820                2825                2830        
Thr Val Thr Asp Arg Val Ile Gly Gly Leu Leu Ala Gly Gln Thr Tyr
        2835                2840                2845            
His Val Ala Val Val Cys Tyr Leu Arg Ser Gln Val Arg Ala Thr Tyr
    2850                2855                2860                
His Gly Ser Phe Ser Thr Lys Lys Ser Gln Pro Pro Pro Pro Gln Pro
2865                2870                2875                2880
Ala Arg Ser Ala Ser Ser Ser Thr Ile Asn Leu Met Val Ser Thr Glu
                2885                2890                2895    
Pro Leu Ala Leu Thr Glu Thr Asp Ile Cys Lys Leu Pro Lys Asp Glu
            2900                2905                2910        
Gly Thr Cys Arg Asp Phe Ile Leu Lys Trp Tyr Tyr Asp Pro Asn Thr
        2915                2920                2925            
Lys Ser Cys Ala Arg Phe Trp Tyr Gly Gly Cys Gly Gly Asn Glu Asn
    2930                2935                2940                
Lys Phe Gly Ser Gln Lys Glu Cys Glu Lys Val Cys Ala Pro Val Leu
2945                2950                2955                2960
Ala Lys Pro Gly Val Ile Ser Val Met Gly Thr
                2965                2970    


<210> 5610
<211> 2975
<212> PRT
<213> Homo sapiens

<400> 5610
Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe
 1               5                  10                  15      
Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val
            20                  25                  30          
Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp
        35                  40                  45              
Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp
    50                  55                  60                  
Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu
65                  70                  75                  80  
Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr
                85                  90                  95      
Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile
            100                 105                 110         
Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser
        115                 120                 125             
His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln
    130                 135                 140                 
Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu
145                 150                 155                 160 
Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly
                165                 170                 175     
Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro
            180                 185                 190         
Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp
        195                 200                 205             
Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu
    210                 215                 220                 
Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Val Ile Glu Val
225                 230                 235                 240 
Asn Lys Arg Asp Ile Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly
                245                 250                 255     
Leu Ala Asn Phe Asn Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln
            260                 265                 270         
Arg Leu Glu Ile Gly Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr
        275                 280                 285             
Ala Asp Thr Val Arg Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys
    290                 295                 300                 
Arg Glu Val Ile Thr Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser
305                 310                 315                 320 
Ala Leu Tyr Thr Gly Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe
                325                 330                 335     
Thr Ser Ser Ala Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu
            340                 345                 350         
Val Leu Ile Thr Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala
        355                 360                 365             
Gln Glu Leu Lys Arg Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys
    370                 375                 380                 
Gly Ala Asp Gln Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu
385                 390                 395                 400 
Val Phe Ile Pro Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu
                405                 410                 415     
Pro Gly Leu Leu Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val
            420                 425                 430         
His Ser Asn Lys Arg Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn
        435                 440                 445             
Val Gly Lys Thr Asn Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu
    450                 455                 460                 
Val Asn Ser Leu Asp Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val
465                 470                 475                 480 
Gln Phe Ser Asp Thr Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln
                485                 490                 495     
Thr Lys Ser Asp Ile Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly
            500                 505                 510         
Gly Ser Gly Leu Asn Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn
        515                 520                 525             
His Phe Thr Glu Ala Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln
    530                 535                 540                 
Leu Leu Leu Leu Leu Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln
545                 550                 555                 560 
Ala Ala Asn Ala Leu Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly
                565                 570                 575     
Ala Ser Gln Ala Asn Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro
            580                 585                 590         
Ser Leu Val Tyr Leu Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro
        595                 600                 605             
Gln Gln Leu Ile Gln Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu
    610                 615                 620                 
Glu Val Pro Leu Ala Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu
625                 630                 635                 640 
Phe Asp Gly Ser Ala Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp
                645                 650                 655     
Phe Leu Tyr Lys Ile Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr
            660                 665                 670         
Arg Ile Ala Val Ala Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg
        675                 680                 685             
Phe Asp Glu His Gln Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg
    690                 695                 700                 
Met Lys Ile Lys Thr Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp
705                 710                 715                 720 
Tyr Ala Gln Arg Tyr Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu
                725                 730                 735     
Asp Gly Val Leu Gln Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser
            740                 745                 750         
Asp Arg Val Asp Gly Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val
        755                 760                 765             
Pro Phe Ile Phe Gln Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln
    770                 775                 780                 
Ile Val Leu Ser Pro Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys
785                 790                 795                 800 
Ile Gly Asp Leu His Pro Gln Ile Val Asn Leu Leu Lys Ser Val His
                805                 810                 815     
Asn Gly Ala Pro Ala Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu
            820                 825                 830         
Leu Asp Gly Ser Glu Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu
        835                 840                 845             
Phe Val Gln Arg Val Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val
    850                 855                 860                 
Arg Val Ala Val Val Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr
865                 870                 875                 880 
Leu Asn Ser Tyr Met Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln
                885                 890                 895     
Leu Thr Leu Leu Gly Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu
            900                 905                 910         
Phe Val Leu Arg Asn Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr
        915                 920                 925             
Glu Gly Val Pro Gln Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly
    930                 935                 940                 
Asp Asp Val Arg Asn Pro Ser Val Val Val Lys Arg Gly Gly Ala Val
945                 950                 955                 960 
Pro Ile Gly Ile Gly Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr
                965                 970                 975     
Ile Ser Phe Ile Pro Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln
            980                 985                 990         
Leu Gly Thr Val Gln Gln Val Ile Ser Glu Arg Val Thr Gln Leu Thr
        995                 1000                1005            
Arg Glu Glu Leu Ser Arg Leu Gln Pro Val Leu Gln Pro Leu Pro Ser
    1010                1015                1020                
Pro Gly Val Gly Gly Lys Arg Asp Val Val Phe Leu Ile Asp Gly Ser
1025                1030                1035                1040
Gln Ser Ala Gly Pro Glu Phe Gln Tyr Val Arg Thr Leu Ile Glu Arg
                1045                1050                1055    
Leu Val Asp Tyr Leu Asp Val Gly Phe Asp Thr Thr Arg Val Ala Val
            1060                1065                1070        
Ile Gln Phe Ser Asp Asp Pro Lys Ala Glu Phe Leu Leu Asn Ala His
        1075                1080                1085            
Ser Ser Lys Asp Glu Val Gln Asn Ala Val Gln Arg Leu Arg Pro Lys
    1090                1095                1100                
Gly Gly Arg Gln Ile Asn Val Gly Asn Ala Leu Glu Tyr Val Ser Arg
1105                1110                1115                1120
Asn Ile Phe Lys Arg Pro Leu Gly Ser Arg Ile Glu Glu Gly Val Pro
                1125                1130                1135    
Gln Phe Leu Val Leu Ile Ser Ser Gly Lys Ser Asp Asp Glu Val Val
            1140                1145                1150        
Val Pro Ala Val Glu Leu Lys Gln Phe Gly Val Ala Pro Phe Thr Ile
        1155                1160                1165            
Ala Arg Asn Ala Asp Gln Glu Glu Leu Val Lys Ile Ser Leu Ser Pro
    1170                1175                1180                
Glu Tyr Val Phe Ser Val Ser Thr Phe Arg Glu Leu Pro Ser Leu Glu
1185                1190                1195                1200
Gln Lys Leu Leu Thr Pro Ile Thr Thr Leu Thr Ser Glu Gln Ile Gln
                1205                1210                1215    
Lys Leu Leu Ala Ser Thr Arg Tyr Pro Pro Pro Ala Val Glu Ser Asp
            1220                1225                1230        
Ala Ala Asp Ile Val Phe Leu Ile Asp Ser Ser Glu Gly Val Arg Pro
        1235                1240                1245            
Asp Gly Phe Ala His Ile Arg Asp Phe Val Ser Arg Ile Val Arg Arg
    1250                1255                1260                
Leu Asn Ile Gly Pro Ser Lys Val Arg Val Gly Val Val Gln Phe Ser
1265                1270                1275                1280
Asn Asp Val Phe Pro Glu Phe Tyr Leu Lys Thr Tyr Arg Ser Gln Ala
                1285                1290                1295    
Pro Val Leu Asp Ala Ile Arg Arg Leu Arg Leu Arg Gly Gly Ser Pro
            1300                1305                1310        
Leu Asn Thr Gly Lys Ala Leu Glu Phe Val Ala Arg Asn Leu Phe Val
        1315                1320                1325            
Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Pro Gln His Leu Val
    1330                1335                1340                
Leu Val Leu Gly Gly Lys Ser Gln Asp Asp Val Ser Arg Phe Ala Gln
1345                1350                1355                1360
Val Ile Arg Ser Ser Gly Ile Val Ser Leu Gly Val Gly Asp Arg Asn
                1365                1370                1375    
Ile Asp Arg Thr Glu Leu Gln Thr Ile Thr Asn Asp Pro Arg Leu Val
            1380                1385                1390        
Phe Thr Val Arg Glu Phe Arg Glu Leu Pro Asn Ile Glu Glu Arg Ile
        1395                1400                1405            
Met Asn Ser Phe Gly Pro Ser Ala Ala Thr Pro Ala Pro Pro Gly Val
    1410                1415                1420                
Asp Thr Pro Pro Pro Ser Arg Pro Glu Lys Lys Lys Ala Asp Ile Val
1425                1430                1435                1440
Phe Leu Leu Asp Gly Ser Ile Asn Phe Arg Arg Asp Ser Phe Gln Glu
                1445                1450                1455    
Val Leu Arg Phe Val Ser Glu Ile Val Asp Thr Val Tyr Glu Asp Gly
            1460                1465                1470        
Asp Ser Ile Gln Val Gly Leu Val Gln Tyr Asn Ser Asp Pro Thr Asp
        1475                1480                1485            
Glu Phe Phe Leu Lys Asp Phe Ser Thr Lys Arg Gln Ile Ile Asp Ala
    1490                1495                1500                
Ile Asn Lys Val Val Tyr Lys Gly Gly Arg His Ala Asn Thr Lys Val
1505                1510                1515                1520
Gly Leu Glu His Leu Arg Val Asn His Phe Val Pro Glu Ala Gly Ser
                1525                1530                1535    
Arg Leu Asp Gln Arg Val Pro Gln Ile Ala Phe Val Ile Thr Gly Gly
            1540                1545                1550        
Lys Ser Val Glu Asp Ala Gln Asp Val Ser Leu Ala Leu Thr Gln Arg
        1555                1560                1565            
Gly Val Lys Val Phe Ala Val Gly Val Arg Asn Ile Asp Ser Glu Glu
    1570                1575                1580                
Val Gly Lys Ile Ala Ser Asn Ser Ala Thr Ala Phe Arg Val Gly Asn
1585                1590                1595                1600
Val Gln Glu Leu Ser Glu Leu Ser Glu Gln Val Leu Glu Thr Leu His
                1605                1610                1615    
Asp Ala Met His Glu Thr Leu Cys Pro Gly Val Thr Asp Ala Ala Lys
            1620                1625                1630        
Ala Cys Asn Leu Asp Val Ile Leu Gly Phe Asp Gly Ser Arg Asp Gln
        1635                1640                1645            
Asn Val Phe Val Ala Gln Lys Gly Phe Glu Ser Lys Val Asp Ala Ile
    1650                1655                1660                
Leu Asn Arg Ile Ser Gln Met His Arg Val Ser Cys Ser Gly Gly Arg
1665                1670                1675                1680
Ser Pro Thr Val Arg Val Ser Val Val Ala Asn Thr Pro Ser Gly Pro
                1685                1690                1695    
Val Glu Ala Phe Asp Phe Asp Glu Tyr Gln Pro Glu Met Leu Glu Lys
            1700                1705                1710        
Phe Arg Asn Met Arg Ser Gln His Pro Tyr Val Leu Thr Glu Asp Thr
        1715                1720                1725            
Leu Lys Val Tyr Leu Asn Lys Phe Arg Gln Ser Ser Pro Asp Ser Val
    1730                1735                1740                
Lys Val Val Ile His Phe Thr Asp Gly Ala Asp Gly Asp Leu Ala Asp
1745                1750                1755                1760
Leu His Arg Ala Ser Glu Asn Leu Arg Gln Glu Gly Val Arg Ala Leu
                1765                1770                1775    
Ile Leu Val Gly Leu Glu Arg Val Val Asn Leu Glu Arg Leu Met His
            1780                1785                1790        
Leu Glu Phe Gly Arg Gly Phe Met Tyr Asp Arg Pro Leu Arg Leu Asn
        1795                1800                1805            
Leu Leu Asp Leu Asp Tyr Glu Leu Ala Glu Gln Leu Asp Asn Ile Ala
    1810                1815                1820                
Glu Lys Ala Cys Cys Gly Val Pro Cys Lys Cys Ser Gly Gln Arg Gly
1825                1830                1835                1840
Asp Arg Gly Pro Ile Gly Ser Ile Gly Pro Lys Gly Ile Pro Gly Glu
                1845                1850                1855    
Asp Gly Tyr Arg Gly Tyr Pro Gly Asp Glu Gly Gly Pro Gly Glu Arg
            1860                1865                1870        
Gly Pro Pro Gly Val Asn Gly Thr Gln Gly Phe Gln Gly Cys Pro Gly
        1875                1880                1885            
Gln Arg Gly Val Lys Gly Ser Arg Gly Phe Pro Gly Glu Lys Gly Glu
    1890                1895                1900                
Val Gly Glu Ile Gly Leu Asp Gly Leu Asp Gly Glu Asp Gly Asp Lys
1905                1910                1915                1920
Gly Leu Pro Gly Ser Ser Gly Glu Lys Gly Asn Pro Gly Arg Arg Gly
                1925                1930                1935    
Asp Lys Gly Pro Arg Gly Glu Lys Gly Glu Arg Gly Asp Val Gly Ile
            1940                1945                1950        
Arg Gly Asp Pro Gly Asn Pro Gly Gln Asp Ser Gln Glu Arg Gly Pro
        1955                1960                1965            
Lys Gly Glu Thr Gly Asp Leu Gly Pro Met Gly Val Pro Gly Arg Asp
    1970                1975                1980                
Gly Val Pro Gly Gly Pro Gly Glu Thr Gly Lys Asn Gly Gly Phe Gly
1985                1990                1995                2000
Arg Arg Gly Pro Pro Gly Ala Lys Gly Asn Lys Gly Gly Pro Gly Gln
                2005                2010                2015    
Pro Gly Phe Glu Gly Glu Gln Gly Thr Arg Gly Ala Gln Gly Pro Ala
            2020                2025                2030        
Gly Pro Ala Gly Pro Pro Gly Leu Ile Gly Glu Gln Gly Ile Ser Gly
        2035                2040                2045            
Pro Arg Gly Ser Gly Gly Ala Arg Gly Ala Pro Gly Glu Arg Gly Arg
    2050                2055                2060                
Thr Gly Pro Leu Gly Arg Lys Gly Glu Pro Gly Glu Pro Gly Pro Lys
2065                2070                2075                2080
Gly Gly Ile Gly Asn Pro Gly Pro Arg Gly Glu Thr Gly Asp Asp Gly
                2085                2090                2095    
Arg Asp Gly Val Gly Ser Glu Gly Arg Arg Gly Lys Lys Gly Glu Arg
            2100                2105                2110        
Gly Phe Pro Gly Tyr Pro Gly Pro Lys Gly Asn Pro Gly Glu Pro Gly
        2115                2120                2125            
Leu Asn Gly Thr Thr Gly Pro Lys Gly Ile Arg Gly Arg Arg Gly Asn
    2130                2135                2140                
Ser Gly Pro Pro Gly Ile Val Gly Gln Lys Gly Arg Pro Gly Tyr Pro
2145                2150                2155                2160
Gly Pro Ala Gly Pro Arg Gly Asn Arg Gly Asp Ser Ile Asp Gln Cys
                2165                2170                2175    
Ala Leu Ile Gln Ser Ile Lys Asp Lys Cys Pro Cys Cys Tyr Gly Pro
            2180                2185                2190        
Leu Glu Cys Pro Val Phe Pro Thr Glu Leu Ala Phe Ala Leu Asp Thr
        2195                2200                2205            
Ser Glu Gly Val Asn Gln Asp Thr Phe Gly Arg Met Arg Asp Val Val
    2210                2215                2220                
Leu Ser Ile Val Asn Val Leu Thr Ile Ala Glu Ser Asn Cys Pro Thr
2225                2230                2235                2240
Gly Ala Arg Val Ala Val Val Thr Tyr Asn Asn Glu Val Thr Thr Glu
                2245                2250                2255    
Ile Arg Phe Ala Asp Ser Lys Arg Lys Ser Val Leu Leu Asp Lys Ile
            2260                2265                2270        
Lys Asn Leu Gln Val Ala Leu Thr Ser Lys Gln Gln Ser Leu Glu Thr
        2275                2280                2285            
Ala Met Ser Phe Val Ala Arg Asn Thr Phe Lys Arg Val Arg Asn Gly
    2290                2295                2300                
Phe Leu Met Arg Lys Val Ala Val Phe Phe Ser Asn Thr Pro Thr Arg
2305                2310                2315                2320
Ala Ser Pro Gln Leu Arg Glu Ala Val Leu Lys Leu Ser Asp Ala Gly
                2325                2330                2335    
Ile Thr Pro Leu Phe Leu Thr Arg Gln Glu Asp Arg Gln Leu Ile Asn
            2340                2345                2350        
Ala Leu Gln Ile Asn Asn Thr Ala Val Gly His Ala Leu Val Leu Pro
        2355                2360                2365            
Ala Gly Arg Asp Leu Thr Asp Phe Leu Glu Asn Val Leu Thr Cys His
    2370                2375                2380                
Val Cys Leu Asp Ile Cys Asn Ile Asp Pro Ser Cys Gly Phe Gly Ser
2385                2390                2395                2400
Trp Arg Pro Ser Phe Arg Asp Arg Arg Ala Ala Gly Ser Asp Val Asp
                2405                2410                2415    
Ile Asp Met Ala Phe Ile Leu Asp Ser Ala Glu Thr Thr Thr Leu Phe
            2420                2425                2430        
Gln Phe Asn Glu Met Lys Lys Tyr Ile Ala Tyr Leu Val Arg Gln Leu
        2435                2440                2445            
Asp Met Ser Pro Asp Pro Lys Ala Ser Gln His Phe Ala Arg Val Ala
    2450                2455                2460                
Val Val Gln His Ala Pro Ser Glu Ser Val Asp Asn Ala Ser Met Pro
2465                2470                2475                2480
Pro Val Lys Val Glu Phe Ser Leu Thr Asp Tyr Gly Ser Lys Glu Lys
                2485                2490                2495    
Leu Val Asp Phe Leu Ser Arg Gly Met Thr Gln Leu Gln Gly Thr Arg
            2500                2505                2510        
Ala Leu Gly Ser Ala Ile Glu Tyr Thr Ile Glu Asn Val Phe Glu Ser
        2515                2520                2525            
Ala Pro Asn Pro Arg Asp Leu Lys Ile Val Val Leu Met Leu Thr Gly
    2530                2535                2540                
Glu Val Pro Glu Gln Gln Leu Glu Glu Ala Gln Arg Val Ile Leu Gln
2545                2550                2555                2560
Ala Lys Cys Lys Gly Tyr Phe Phe Val Val Leu Gly Ile Gly Arg Lys
                2565                2570                2575    
Val Asn Ile Lys Glu Val Tyr Thr Phe Ala Ser Glu Pro Asn Asp Val
            2580                2585                2590        
Phe Phe Lys Leu Val Asp Lys Ser Thr Glu Leu Asn Glu Glu Pro Leu
        2595                2600                2605            
Met Arg Phe Gly Arg Leu Leu Pro Ser Phe Val Ser Ser Glu Asn Ala
    2610                2615                2620                
Phe Tyr Leu Ser Pro Asp Ile Arg Lys Gln Cys Asp Trp Phe Gln Gly
2625                2630                2635                2640
Asp Gln Pro Thr Lys Asn Leu Val Lys Phe Gly His Lys Gln Val Asn
                2645                2650                2655    
Val Pro Asn Asn Val Thr Ser Ser Pro Thr Ser Asn Pro Val Thr Thr
            2660                2665                2670        
Thr Lys Pro Val Thr Thr Thr Lys Pro Val Thr Thr Thr Thr Lys Pro
        2675                2680                2685            
Val Thr Thr Thr Thr Lys Pro Val Thr Ile Ile Asn Gln Pro Ser Val
    2690                2695                2700                
Lys Pro Ala Ala Ala Lys Pro Ala Pro Ala Lys Pro Val Ala Ala Lys
2705                2710                2715                2720
Pro Val Ala Thr Lys Thr Ala Thr Val Arg Pro Pro Val Ala Val Lys
                2725                2730                2735    
Pro Ala Thr Ala Ala Lys Pro Val Ala Ala Lys Pro Ala Ala Val Arg
            2740                2745                2750        
Pro Pro Ala Ala Ala Ala Lys Pro Val Ala Thr Lys Pro Glu Val Pro
        2755                2760                2765            
Arg Pro Gln Ala Ala Lys Pro Ala Ala Thr Lys Pro Ala Thr Thr Lys
    2770                2775                2780                
Pro Val Val Lys Met Leu Arg Glu Val Gln Val Phe Glu Ile Thr Glu
2785                2790                2795                2800
Asn Ser Ala Lys Leu His Trp Glu Arg Pro Glu Pro Pro Gly Pro Tyr
                2805                2810                2815    
Phe Tyr Asp Leu Thr Val Thr Ser Ala His Asp Gln Ser Leu Val Leu
            2820                2825                2830        
Lys Gln Asn Leu Thr Val Thr Asp Arg Val Ile Gly Gly Leu Leu Ala
        2835                2840                2845            
Gly Gln Thr Tyr His Val Ala Val Val Cys Tyr Leu Arg Ser Gln Val
    2850                2855                2860                
Arg Ala Thr Tyr His Gly Ser Phe Ser Thr Lys Lys Ser Gln Pro Pro
2865                2870                2875                2880
Pro Pro Gln Pro Ala Arg Ser Ala Ser Ser Ser Thr Ile Asn Leu Met
                2885                2890                2895    
Val Ser Thr Glu Pro Leu Ala Leu Thr Glu Thr Asp Ile Cys Lys Leu
            2900                2905                2910        
Pro Lys Asp Glu Gly Thr Cys Arg Asp Phe Ile Leu Lys Trp Tyr Tyr
        2915                2920                2925            
Asp Pro Asn Thr Lys Ser Cys Ala Arg Phe Trp Tyr Gly Gly Cys Gly
    2930                2935                2940                
Gly Asn Glu Asn Lys Phe Gly Ser Gln Lys Glu Cys Glu Lys Val Cys
2945                2950                2955                2960
Ala Pro Val Leu Ala Lys Pro Gly Val Ile Ser Val Met Gly Thr
                2965                2970                2975


<210> 5611
<211> 3009
<212> PRT
<213> Homo sapiens

<400> 5611
Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe
 1               5                  10                  15      
Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val
            20                  25                  30          
Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp
        35                  40                  45              
Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp
    50                  55                  60                  
Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu
65                  70                  75                  80  
Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr
                85                  90                  95      
Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile
            100                 105                 110         
Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser
        115                 120                 125             
His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln
    130                 135                 140                 
Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu
145                 150                 155                 160 
Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly
                165                 170                 175     
Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro
            180                 185                 190         
Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp
        195                 200                 205             
Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu
    210                 215                 220                 
Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser
225                 230                 235                 240 
Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val
                245                 250                 255     
Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu
            260                 265                 270         
Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp
        275                 280                 285             
Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln
    290                 295                 300                 
Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala
305                 310                 315                 320 
Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg
                325                 330                 335     
Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu
            340                 345                 350         
Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala
        355                 360                 365             
Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala
    370                 375                 380                 
Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe
385                 390                 395                 400 
Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu
                405                 410                 415     
Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro
            420                 425                 430         
Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe
        435                 440                 445             
Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile
    450                 455                 460                 
Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp
465                 470                 475                 480 
Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu
                485                 490                 495     
Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val
            500                 505                 510         
Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala
        515                 520                 525             
Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg
    530                 535                 540                 
Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys
545                 550                 555                 560 
Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser
                565                 570                 575     
Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu
            580                 585                 590         
Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe
        595                 600                 605             
Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu
    610                 615                 620                 
Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg Asp Ile
625                 630                 635                 640 
Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn Phe Pro
                645                 650                 655     
Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp Ile Gly
            660                 665                 670         
Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr Pro Val
        675                 680                 685             
Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile Leu Gly
    690                 695                 700                 
His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn Thr Gly
705                 710                 715                 720 
Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala Gly Gly
                725                 730                 735     
Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu Thr Ala
            740                 745                 750         
Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu Thr Arg
        755                 760                 765             
Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn Lys Ala
    770                 775                 780                 
Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu Met Asp
785                 790                 795                 800 
Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln Pro Leu
                805                 810                 815     
Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala Gln Pro
            820                 825                 830         
Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn Leu
        835                 840                 845             
Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile Asp
    850                 855                 860                 
Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln Tyr
865                 870                 875                 880 
Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser Lys
                885                 890                 895     
Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly Lys
            900                 905                 910         
Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile Phe
        915                 920                 925             
Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe Leu
    930                 935                 940                 
Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro Ala
945                 950                 955                 960 
Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala Lys
                965                 970                 975     
Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala Phe
            980                 985                 990         
Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His Pro Gln
        995                 1000                1005            
Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala Pro Val
    1010                1015                1020                
Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu Gly Val
1025                1030                1035                1040
Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val Val Glu
                1045                1050                1055    
Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val Gln Tyr
            1060                1065                1070        
Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met Asn Lys
        1075                1080                1085            
Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly Gly Pro
    1090                1095                1100                
Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn Ile Leu
1105                1110                1115                1120
Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln Leu Leu
                1125                1130                1135    
Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn Pro Ser
            1140                1145                1150        
Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly Ile Gly
        1155                1160                1165            
Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro Asp Phe
    1170                1175                1180                
Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln Gln Val
1185                1190                1195                1200
Ile Ser Glu Arg Val Thr Gln Leu Thr Arg Glu Glu Leu Ser Arg Leu
                1205                1210                1215    
Gln Pro Val Leu Gln Pro Leu Pro Ser Pro Gly Val Gly Gly Lys Arg
            1220                1225                1230        
Asp Val Val Phe Leu Ile Asp Gly Ser Gln Ser Ala Gly Pro Glu Phe
        1235                1240                1245            
Gln Tyr Val Arg Thr Leu Ile Glu Arg Leu Val Asp Tyr Leu Asp Val
    1250                1255                1260                
Gly Phe Asp Thr Thr Arg Val Ala Val Ile Gln Phe Ser Asp Asp Pro
1265                1270                1275                1280
Lys Ala Glu Phe Leu Leu Asn Ala His Ser Ser Lys Asp Glu Val Gln
                1285                1290                1295    
Asn Ala Val Gln Arg Leu Arg Pro Lys Gly Gly Arg Gln Ile Asn Val
            1300                1305                1310        
Gly Asn Ala Leu Glu Tyr Val Ser Arg Asn Ile Phe Lys Arg Pro Leu
        1315                1320                1325            
Gly Ser Arg Ile Glu Glu Gly Val Pro Gln Phe Leu Val Leu Ile Ser
    1330                1335                1340                
Ser Gly Lys Ser Asp Asp Glu Val Val Val Pro Ala Val Glu Leu Lys
1345                1350                1355                1360
Gln Phe Gly Val Ala Pro Phe Thr Ile Ala Arg Asn Ala Asp Gln Glu
                1365                1370                1375    
Glu Leu Val Lys Ile Ser Leu Ser Pro Glu Tyr Val Phe Ser Val Ser
            1380                1385                1390        
Thr Phe Arg Glu Leu Pro Ser Leu Glu Gln Lys Leu Leu Thr Pro Ile
        1395                1400                1405            
Thr Thr Leu Thr Ser Glu Gln Ile Gln Lys Leu Leu Ala Ser Thr Arg
    1410                1415                1420                
Tyr Pro Pro Pro Val Arg Glu Phe Arg Glu Leu Pro Asn Ile Glu Glu
1425                1430                1435                1440
Arg Ile Met Asn Ser Phe Gly Pro Ser Ala Ala Thr Pro Ala Pro Pro
                1445                1450                1455    
Gly Val Asp Thr Pro Pro Pro Ser Arg Pro Glu Lys Lys Lys Ala Asp
            1460                1465                1470        
Ile Val Phe Leu Leu Asp Gly Ser Ile Asn Phe Arg Arg Asp Ser Phe
        1475                1480                1485            
Gln Glu Val Leu Arg Phe Val Ser Glu Ile Val Asp Thr Val Tyr Glu
    1490                1495                1500                
Asp Gly Asp Ser Ile Gln Val Gly Leu Val Gln Tyr Asn Ser Asp Pro
1505                1510                1515                1520
Thr Asp Glu Phe Phe Leu Lys Asp Phe Ser Thr Lys Arg Gln Ile Ile
                1525                1530                1535    
Asp Ala Ile Asn Lys Val Val Tyr Lys Gly Gly Arg His Ala Asn Thr
            1540                1545                1550        
Lys Val Gly Leu Glu His Leu Arg Val Asn His Phe Val Pro Glu Ala
        1555                1560                1565            
Gly Ser Arg Leu Asp Gln Arg Val Pro Gln Ile Ala Phe Val Ile Thr
    1570                1575                1580                
Gly Gly Lys Ser Val Glu Asp Ala Gln Asp Val Ser Leu Ala Leu Thr
1585                1590                1595                1600
Gln Arg Gly Val Lys Val Phe Ala Val Gly Val Arg Asn Ile Asp Ser
                1605                1610                1615    
Glu Glu Val Gly Lys Ile Ala Ser Asn Ser Ala Thr Ala Phe Arg Val
            1620                1625                1630        
Gly Asn Val Gln Glu Leu Ser Glu Leu Ser Glu Gln Val Leu Glu Thr
        1635                1640                1645            
Leu His Asp Ala Met His Glu Thr Leu Cys Pro Gly Val Thr Asp Ala
    1650                1655                1660                
Ala Lys Ala Cys Asn Leu Asp Val Ile Leu Gly Phe Asp Gly Ser Arg
1665                1670                1675                1680
Asp Gln Asn Val Phe Val Ala Gln Lys Gly Phe Glu Ser Lys Val Asp
                1685                1690                1695    
Ala Ile Leu Asn Arg Ile Ser Gln Met His Arg Val Ser Cys Ser Gly
            1700                1705                1710        
Gly Arg Ser Pro Thr Val Arg Val Ser Val Val Ala Asn Thr Pro Ser
        1715                1720                1725            
Gly Pro Val Glu Ala Phe Asp Phe Asp Glu Tyr Gln Pro Glu Met Leu
    1730                1735                1740                
Glu Lys Phe Arg Asn Met Arg Ser Gln His Pro Tyr Val Leu Thr Glu
1745                1750                1755                1760
Asp Thr Leu Lys Val Tyr Leu Asn Lys Phe Arg Gln Ser Ser Pro Asp
                1765                1770                1775    
Ser Val Lys Val Val Ile His Phe Thr Asp Gly Ala Asp Gly Asp Leu
            1780                1785                1790        
Ala Asp Leu His Arg Ala Ser Glu Asn Leu Arg Gln Glu Gly Val Arg
        1795                1800                1805            
Ala Leu Ile Leu Val Gly Leu Glu Arg Val Val Asn Leu Glu Arg Leu
    1810                1815                1820                
Met His Leu Glu Phe Gly Arg Gly Phe Met Tyr Asp Arg Pro Leu Arg
1825                1830                1835                1840
Leu Asn Leu Leu Asp Leu Asp Tyr Glu Leu Ala Glu Gln Leu Asp Asn
                1845                1850                1855    
Ile Ala Glu Lys Ala Cys Cys Gly Val Pro Cys Lys Cys Ser Gly Gln
            1860                1865                1870        
Arg Gly Asp Arg Gly Pro Ile Gly Ser Ile Gly Pro Lys Gly Ile Pro
        1875                1880                1885            
Gly Glu Asp Gly Tyr Arg Gly Tyr Pro Gly Asp Glu Gly Gly Pro Gly
    1890                1895                1900                
Glu Arg Gly Pro Pro Gly Val Asn Gly Thr Gln Gly Phe Gln Gly Cys
1905                1910                1915                1920
Pro Gly Gln Arg Gly Val Lys Gly Ser Arg Gly Phe Pro Gly Glu Lys
                1925                1930                1935    
Gly Glu Val Gly Glu Ile Gly Leu Asp Gly Leu Asp Gly Glu Asp Gly
            1940                1945                1950        
Asp Lys Gly Leu Pro Gly Ser Ser Gly Glu Lys Gly Asn Pro Gly Arg
        1955                1960                1965            
Arg Gly Asp Lys Gly Pro Arg Gly Glu Lys Gly Glu Arg Gly Asp Val
    1970                1975                1980                
Gly Ile Arg Gly Asp Pro Gly Asn Pro Gly Gln Asp Ser Gln Glu Arg
1985                1990                1995                2000
Gly Pro Lys Gly Glu Thr Gly Asp Leu Gly Pro Met Gly Val Pro Gly
                2005                2010                2015    
Arg Asp Gly Val Pro Gly Gly Pro Gly Glu Thr Gly Lys Asn Gly Gly
            2020                2025                2030        
Phe Gly Arg Arg Gly Pro Pro Gly Ala Lys Gly Asn Lys Gly Gly Pro
        2035                2040                2045            
Gly Gln Pro Gly Phe Glu Gly Glu Gln Gly Thr Arg Gly Ala Gln Gly
    2050                2055                2060                
Pro Ala Gly Pro Ala Gly Pro Pro Gly Leu Ile Gly Glu Gln Gly Ile
2065                2070                2075                2080
Ser Gly Pro Arg Gly Ser Gly Gly Ala Arg Gly Ala Pro Gly Glu Arg
                2085                2090                2095    
Gly Arg Thr Gly Pro Leu Gly Arg Lys Gly Glu Pro Gly Glu Pro Gly
            2100                2105                2110        
Pro Lys Gly Gly Ile Gly Asn Pro Gly Pro Arg Gly Glu Thr Gly Asp
        2115                2120                2125            
Asp Gly Arg Asp Gly Val Gly Ser Glu Gly Arg Arg Gly Lys Lys Gly
    2130                2135                2140                
Glu Arg Gly Phe Pro Gly Tyr Pro Gly Pro Lys Gly Asn Pro Gly Glu
2145                2150                2155                2160
Pro Gly Leu Asn Gly Thr Thr Gly Pro Lys Gly Ile Arg Gly Arg Arg
                2165                2170                2175    
Gly Asn Ser Gly Pro Pro Gly Ile Val Gly Gln Lys Gly Arg Pro Gly
            2180                2185                2190        
Tyr Pro Gly Pro Ala Gly Pro Arg Gly Asn Arg Gly Asp Ser Ile Asp
        2195                2200                2205            
Gln Cys Ala Leu Ile Gln Ser Ile Lys Asp Lys Cys Pro Cys Cys Tyr
    2210                2215                2220                
Gly Pro Leu Glu Cys Pro Val Phe Pro Thr Glu Leu Ala Phe Ala Leu
2225                2230                2235                2240
Asp Thr Ser Glu Gly Val Asn Gln Asp Thr Phe Gly Arg Met Arg Asp
                2245                2250                2255    
Val Val Leu Ser Ile Val Asn Val Leu Thr Ile Ala Glu Ser Asn Cys
            2260                2265                2270        
Pro Thr Gly Ala Arg Val Ala Val Val Thr Tyr Asn Asn Glu Val Thr
        2275                2280                2285            
Thr Glu Ile Arg Phe Ala Asp Ser Lys Arg Lys Ser Val Leu Leu Asp
    2290                2295                2300                
Lys Ile Lys Asn Leu Gln Val Ala Leu Thr Ser Lys Gln Gln Ser Leu
2305                2310                2315                2320
Glu Thr Ala Met Ser Phe Val Ala Arg Asn Thr Phe Lys Arg Val Arg
                2325                2330                2335    
Asn Gly Phe Leu Met Arg Lys Val Ala Val Phe Phe Ser Asn Thr Pro
            2340                2345                2350        
Thr Arg Ala Ser Pro Gln Leu Arg Glu Ala Val Leu Lys Leu Ser Asp
        2355                2360                2365            
Ala Gly Ile Thr Pro Leu Phe Leu Thr Arg Gln Glu Asp Arg Gln Leu
    2370                2375                2380                
Ile Asn Ala Leu Gln Ile Asn Asn Thr Ala Val Gly His Ala Leu Val
2385                2390                2395                2400
Leu Pro Ala Gly Arg Asp Leu Thr Asp Phe Leu Glu Asn Val Leu Thr
                2405                2410                2415    
Cys His Val Cys Leu Asp Ile Cys Asn Ile Asp Pro Ser Cys Gly Phe
            2420                2425                2430        
Gly Ser Trp Arg Pro Ser Phe Arg Asp Arg Arg Ala Ala Gly Ser Asp
        2435                2440                2445            
Val Asp Ile Asp Met Ala Phe Ile Leu Asp Ser Ala Glu Thr Thr Thr
    2450                2455                2460                
Leu Phe Gln Phe Asn Glu Met Lys Lys Tyr Ile Ala Tyr Leu Val Arg
2465                2470                2475                2480
Gln Leu Asp Met Ser Pro Asp Pro Lys Ala Ser Gln His Phe Ala Arg
                2485                2490                2495    
Val Ala Val Val Gln His Ala Pro Ser Glu Ser Val Asp Asn Ala Ser
            2500                2505                2510        
Met Pro Pro Val Lys Val Glu Phe Ser Leu Thr Asp Tyr Gly Ser Lys
        2515                2520                2525            
Glu Lys Leu Val Asp Phe Leu Ser Arg Gly Met Thr Gln Leu Gln Gly
    2530                2535                2540                
Thr Arg Ala Leu Gly Ser Ala Ile Glu Tyr Thr Ile Glu Asn Val Phe
2545                2550                2555                2560
Glu Ser Ala Pro Asn Pro Arg Asp Leu Lys Ile Val Val Leu Met Leu
                2565                2570                2575    
Thr Gly Glu Val Pro Glu Gln Gln Leu Glu Glu Ala Gln Arg Val Ile
            2580                2585                2590        
Leu Gln Ala Lys Cys Lys Gly Tyr Phe Phe Val Val Leu Gly Ile Gly
        2595                2600                2605            
Arg Lys Val Asn Ile Lys Glu Val Tyr Thr Phe Ala Ser Glu Pro Asn
    2610                2615                2620                
Asp Val Phe Phe Lys Leu Val Asp Lys Ser Thr Glu Leu Asn Glu Glu
2625                2630                2635                2640
Pro Leu Met Arg Phe Gly Arg Leu Leu Pro Ser Phe Val Ser Ser Glu
                2645                2650                2655    
Asn Ala Phe Tyr Leu Ser Pro Asp Ile Arg Lys Gln Cys Asp Trp Phe
            2660                2665                2670        
Gln Gly Asp Gln Pro Thr Lys Asn Leu Val Lys Phe Gly His Lys Gln
        2675                2680                2685            
Val Asn Val Pro Asn Asn Val Thr Ser Ser Pro Thr Ser Asn Pro Val
    2690                2695                2700                
Thr Thr Thr Lys Pro Val Thr Thr Thr Lys Pro Val Thr Thr Thr Thr
2705                2710                2715                2720
Lys Pro Val Thr Thr Thr Thr Lys Pro Val Thr Ile Ile Asn Gln Pro
                2725                2730                2735    
Ser Val Lys Pro Ala Ala Ala Lys Pro Ala Pro Ala Lys Pro Val Ala
            2740                2745                2750        
Ala Lys Pro Val Ala Thr Lys Thr Ala Thr Val Arg Pro Pro Val Ala
        2755                2760                2765            
Val Lys Pro Ala Thr Ala Ala Lys Pro Val Ala Ala Lys Pro Ala Ala
    2770                2775                2780                
Val Arg Pro Pro Ala Ala Ala Ala Lys Pro Val Ala Thr Lys Pro Glu
2785                2790                2795                2800
Val Pro Arg Pro Gln Ala Ala Lys Pro Ala Ala Thr Lys Pro Ala Thr
                2805                2810                2815    
Thr Lys Pro Val Val Lys Met Leu Arg Glu Val Gln Val Phe Glu Ile
            2820                2825                2830        
Thr Glu Asn Ser Ala Lys Leu His Trp Glu Arg Pro Glu Pro Pro Gly
        2835                2840                2845            
Pro Tyr Phe Tyr Asp Leu Thr Val Thr Ser Ala His Asp Gln Ser Leu
    2850                2855                2860                
Val Leu Lys Gln Asn Leu Thr Val Thr Asp Arg Val Ile Gly Gly Leu
2865                2870                2875                2880
Leu Ala Gly Gln Thr Tyr His Val Ala Val Val Cys Tyr Leu Arg Ser
                2885                2890                2895    
Gln Val Arg Ala Thr Tyr His Gly Ser Phe Ser Thr Lys Lys Ser Gln
            2900                2905                2910        
Pro Pro Pro Pro Gln Pro Ala Arg Ser Ala Ser Ser Ser Thr Ile Asn
        2915                2920                2925            
Leu Met Val Ser Thr Glu Pro Leu Ala Leu Thr Glu Thr Asp Ile Cys
    2930                2935                2940                
Lys Leu Pro Lys Asp Glu Gly Thr Cys Arg Asp Phe Ile Leu Lys Trp
2945                2950                2955                2960
Tyr Tyr Asp Pro Asn Thr Lys Ser Cys Ala Arg Phe Trp Tyr Gly Gly
                2965                2970                2975    
Cys Gly Gly Asn Glu Asn Lys Phe Gly Ser Gln Lys Glu Cys Glu Lys
            2980                2985                2990        
Val Cys Ala Pro Val Leu Ala Lys Pro Gly Val Ile Ser Val Met Gly
        2995                3000                3005            
Thr
    


<210> 5612
<211> 569
<212> PRT
<213> Homo sapiens

<400> 5612
Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val
 1               5                  10                  15      
Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe
            20                  25                  30          
Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly
        35                  40                  45              
Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys
    50                  55                  60                  
Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr
65                  70                  75                  80  
Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His
                85                  90                  95      
Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile
            100                 105                 110         
Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser
        115                 120                 125             
Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys
    130                 135                 140                 
Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro
145                 150                 155                 160 
Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg
                165                 170                 175     
Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe
            180                 185                 190         
Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys
        195                 200                 205             
Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys
    210                 215                 220                 
Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn
225                 230                 235                 240 
Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp
                245                 250                 255     
Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile
            260                 265                 270         
Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln
        275                 280                 285             
His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile
    290                 295                 300                 
Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro
305                 310                 315                 320 
Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val
                325                 330                 335     
Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn
            340                 345                 350         
Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser
        355                 360                 365             
Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys
    370                 375                 380                 
Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn
385                 390                 395                 400 
Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu
                405                 410                 415     
Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys
            420                 425                 430         
Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr
        435                 440                 445             
Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro
    450                 455                 460                 
Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser
465                 470                 475                 480 
Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln
                485                 490                 495     
Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu
            500                 505                 510         
Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys
        515                 520                 525             
Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro
    530                 535                 540                 
His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu
545                 550                 555                 560 
Gly Lys Phe Glu Tyr Pro Ile Cys Glu
                565                 


<210> 5613
<211> 1581
<212> PRT
<213> Homo sapiens

<400> 5613
Ala Ala Asn Pro Arg Glu Ala Asp Gly Met Ala Ser Ser Ala Arg Glu
 1               5                  10                  15      
His Leu Leu Phe Val Arg Arg Arg Asn Pro Gln Met Arg Tyr Thr Leu
            20                  25                  30          
Ser Pro Glu Asn Leu Gln Ser Leu Ala Ala Gln Ser Ser Met Pro Glu
        35                  40                  45              
Asn Met Thr Leu Gln Arg Ala Asn Ser Asp Thr Asp Leu Val Thr Ser
    50                  55                  60                  
Glu Ser Arg Ser Ser Leu Thr Ala Ser Met Tyr Glu Tyr Thr Leu Gly
65                  70                  75                  80  
Gln Ala Gln Asn Leu Ile Ile Phe Trp Asp Ile Lys Glu Glu Val Asp
                85                  90                  95      
Pro Ser Asp Trp Ile Gly Leu Tyr His Ile Asp Glu Asn Ser Pro Ala
            100                 105                 110         
Asn Phe Trp Asp Ser Lys Asn Arg Gly Val Thr Gly Thr Gln Lys Gly
        115                 120                 125             
Gln Ile Val Trp Arg Ile Glu Pro Gly Pro Tyr Phe Met Glu Pro Glu
    130                 135                 140                 
Ile Lys Ile Cys Phe Lys Tyr Tyr His Gly Ile Ser Gly Ala Leu Arg
145                 150                 155                 160 
Ala Thr Thr Pro Cys Ile Thr Val Lys Asn Pro Ala Val Met Met Gly
                165                 170                 175     
Ala Glu Gly Met Glu Gly Gly Ala Ser Gly Asn Leu His Ser Arg Lys
            180                 185                 190         
Leu Val Ser Phe Thr Leu Ser Asp Leu Arg Ala Val Gly Leu Lys Lys
        195                 200                 205             
Gly Met Phe Phe Asn Pro Asp Pro Tyr Leu Lys Met Ser Ile Gln Pro
    210                 215                 220                 
Gly Lys Lys Ser Ser Phe Pro Thr Cys Ala His His Gly Gln Glu Arg
225                 230                 235                 240 
Arg Ser Thr Ile Ile Ser Asn Thr Thr Asn Pro Ile Trp His Arg Glu
                245                 250                 255     
Lys Tyr Ser Phe Phe Ala Leu Leu Thr Asp Val Leu Glu Ile Glu Ile
            260                 265                 270         
Lys Asp Lys Phe Ala Lys Ser Arg Pro Ile Ile Lys Arg Phe Leu Gly
        275                 280                 285             
Lys Leu Thr Ile Pro Val Gln Arg Leu Leu Glu Arg Gln Ala Ile Gly
    290                 295                 300                 
Asp Gln Met Leu Ser Tyr Asn Leu Gly Arg Arg Leu Pro Ala Asp His
305                 310                 315                 320 
Val Ser Gly Tyr Leu Gln Phe Lys Val Glu Val Thr Ser Ser Val His
                325                 330                 335     
Glu Asp Ala Ser Pro Glu Ala Val Gly Thr Ile Leu Gly Val Asn Ser
            340                 345                 350         
Val Asn Gly Asp Leu Gly Ser Pro Ser Asp Asp Glu Asp Met Pro Gly
        355                 360                 365             
Ser His His Asp Ser Gln Val Cys Ser Asn Gly Pro Val Ser Glu Asp
    370                 375                 380                 
Ser Ala Ala Asp Gly Thr Pro Lys His Ser Phe Arg Thr Ser Ser Thr
385                 390                 395                 400 
Leu Glu Ile Asp Thr Glu Glu Leu Thr Ser Thr Ser Ser Arg Thr Ser
                405                 410                 415     
Pro Pro Arg Gly Arg Gln Asp Ser Leu Asn Asp Tyr Leu Asp Ala Ile
            420                 425                 430         
Glu His Asn Gly His Ser Arg Pro Gly Thr Ala Thr Cys Ser Glu Arg
        435                 440                 445             
Ser Met Gly Ala Ser Pro Lys Leu Arg Ser Ser Phe Pro Thr Asp Thr
    450                 455                 460                 
Arg Leu Asn Ala Met Leu His Ile Asp Ser Asp Glu Glu Asp His Glu
465                 470                 475                 480 
Phe Gln Gln Asp Leu Gly Tyr Pro Ser Ser Leu Glu Glu Glu Gly Gly
                485                 490                 495     
Leu Ile Met Phe Ser Arg Ala Ser Arg Ala Asp Asp Gly Ser Leu Thr
            500                 505                 510         
Ser Gln Thr Lys Leu Glu Asp Asn Pro Val Glu Asn Glu Glu Ala Ser
        515                 520                 525             
Thr His Glu Ala Ala Ser Phe Glu Asp Lys Pro Glu Asn Leu Pro Glu
    530                 535                 540                 
Leu Ala Glu Ser Ser Leu Pro Ala Gly Pro Ala Pro Glu Glu Gly Glu
545                 550                 555                 560 
Gly Gly Pro Glu Pro Gln Pro Ser Ala Asp Gln Gly Ser Ala Glu Leu
                565                 570                 575     
Cys Gly Ser Gln Glu Val Asp Gln Pro Thr Ser Gly Ala Asp Thr Gly
            580                 585                 590         
Thr Ser Asp Ala Ser Gly Gly Ser Arg Arg Ala Val Ser Glu Thr Glu
        595                 600                 605             
Ser Leu Asp Gln Gly Ser Glu Pro Ser Gln Val Ser Ser Glu Thr Glu
    610                 615                 620                 
Pro Ser Asp Pro Ala Arg Thr Glu Ser Val Ser Glu Ala Ser Thr Arg
625                 630                 635                 640 
Pro Glu Gly Glu Ser Asp Leu Glu Cys Ala Asp Ser Ser Cys Asn Glu
                645                 650                 655     
Ser Val Thr Thr Gln Leu Ser Ser Val Asp Thr Arg Cys Ser Ser Leu
            660                 665                 670         
Glu Ser Ala Arg Phe Pro Glu Thr Pro Ala Phe Ser Ser Gln Glu Glu
        675                 680                 685             
Glu Asp Gly Ala Cys Ala Ala Glu Pro Thr Ser Ser Gly Pro Ala Glu
    690                 695                 700                 
Gly Ser Gln Glu Ser Val Cys Thr Ala Gly Ser Leu Pro Val Val Gln
705                 710                 715                 720 
Val Pro Ser Gly Glu Asp Glu Gly Pro Gly Ala Glu Ser Ala Thr Val
                725                 730                 735     
Pro Asp Gln Glu Glu Leu Gly Glu Val Trp Gln Arg Arg Gly Ser Leu
            740                 745                 750         
Glu Gly Ala Ala Ala Ala Ala Glu Ser Pro Pro Gln Glu Glu Gly Ser
        755                 760                 765             
Ala Gly Glu Ala Gln Gly Thr Cys Glu Gly Ala Thr Ala Gln Glu Glu
    770                 775                 780                 
Gly Ala Thr Gly Gly Ser Gln Ala Asn Gly His Gln Pro Leu Arg Ser
785                 790                 795                 800 
Leu Pro Ser Val Arg Gln Asp Val Ser Arg Tyr Gln Arg Val Asp Glu
                805                 810                 815     
Ala Leu Pro Pro Asn Trp Glu Ala Arg Ile Asp Ser His Gly Arg Ile
            820                 825                 830         
Phe Tyr Val Asp His Val Asn Arg Thr Thr Thr Trp Gln Arg Pro Thr
        835                 840                 845             
Ala Pro Pro Ala Pro Gln Val Leu Gln Arg Ser Asn Ser Ile Gln Gln
    850                 855                 860                 
Met Glu Gln Leu Asn Arg Arg Tyr Gln Ser Ile Arg Arg Thr Met Thr
865                 870                 875                 880 
Asn Glu Arg Pro Glu Glu Asn Thr Asn Ala Ile Asp Gly Ala Gly Glu
                885                 890                 895     
Glu Ala Asp Phe His Gln Ala Ser Ala Asp Phe Arg Arg Glu Asn Ile
            900                 905                 910         
Leu Pro His Ser Thr Ser Arg Ser Arg Ile Thr Leu Leu Leu Gln Ser
        915                 920                 925             
Pro Pro Val Lys Phe Leu Ile Ser Pro Glu Phe Phe Thr Val Leu His
    930                 935                 940                 
Ser Asn Pro Ser Ala Tyr Arg Met Phe Thr Asn Asn Thr Cys Leu Lys
945                 950                 955                 960 
His Met Ile Thr Lys Val Arg Arg Asp Thr His His Phe Glu Arg Tyr
                965                 970                 975     
Gln His Asn Arg Asp Leu Val Gly Phe Leu Asn Met Phe Ala Asn Lys
            980                 985                 990         
Gln Leu Glu Leu Pro Arg Gly Trp Glu Met Lys His Asp His Gln Gly
        995                 1000                1005            
Lys Ala Phe Phe Val Asp His Asn Ser Arg Thr Thr Thr Phe Ile Asp
    1010                1015                1020                
Pro Arg Leu Pro Leu Gln Ser Ser Arg Pro Thr Ser Ala Leu Val His
1025                1030                1035                1040
Arg Gln His Leu Thr Arg Gln Arg Ser His Ser Ala Gly Glu Val Gly
                1045                1050                1055    
Glu Asp Ser Arg His Ala Gly Pro Pro Val Leu Pro Arg Pro Ser Ser
            1060                1065                1070        
Thr Phe Asn Thr Val Ser Arg Pro Gln Tyr Gln Asp Met Val Pro Val
        1075                1080                1085            
Ala Tyr Asn Asp Lys Ile Val Ala Phe Leu Arg Gln Pro Asn Ile Phe
    1090                1095                1100                
Glu Ile Leu Gln Glu Arg Gln Pro Asp Leu Thr Arg Asn His Ser Leu
1105                1110                1115                1120
Arg Glu Lys Ile Gln Phe Ile Arg Thr Glu Gly Thr Pro Gly Leu Val
                1125                1130                1135    
Arg Leu Ser Ser Asp Ala Asp Leu Val Met Leu Leu Ser Leu Phe Glu
            1140                1145                1150        
Glu Glu Ile Met Ser Tyr Val Pro Pro His Ala Leu Leu His Pro Ser
        1155                1160                1165            
Tyr Cys Gln Ser Pro Arg Gly Ser Pro Val Ser Ser Pro Gln Asn Ser
    1170                1175                1180                
Pro Gly Thr Gln Arg Ala Asn Ala Arg Ala Pro Ala Pro Tyr Lys Arg
1185                1190                1195                1200
Asp Phe Glu Ala Lys Leu Arg Asn Phe Tyr Arg Lys Leu Glu Thr Lys
                1205                1210                1215    
Gly Tyr Gly Gln Gly Pro Gly Lys Leu Lys Leu Ile Ile Arg Arg Asp
            1220                1225                1230        
His Leu Leu Glu Asp Ala Phe Asn Gln Ile Met Gly Tyr Ser Arg Lys
        1235                1240                1245            
Asp Leu Gln Arg Asn Lys Leu Tyr Val Thr Phe Val Gly Glu Glu Gly
    1250                1255                1260                
Leu Asp Tyr Ser Gly Pro Ser Arg Glu Phe Phe Phe Leu Val Ser Arg
1265                1270                1275                1280
Glu Leu Phe Asn Pro Tyr Tyr Gly Leu Phe Glu Tyr Ser Ala Asn Asp
                1285                1290                1295    
Thr Tyr Thr Val Gln Ile Ser Pro Met Ser Ala Phe Val Asp Asn His
            1300                1305                1310        
His Glu Trp Phe Arg Phe Ser Gly Arg Ile Leu Gly Leu Ala Leu Ile
        1315                1320                1325            
His Gln Tyr Leu Leu Asp Ala Phe Phe Thr Arg Pro Phe Tyr Lys Ala
    1330                1335                1340                
Leu Leu Arg Ile Leu Cys Asp Leu Ser Asp Leu Glu Tyr Leu Asp Glu
1345                1350                1355                1360
Glu Phe His Gln Ser Leu Gln Trp Met Lys Asp Asn Asp Ile His Asp
                1365                1370                1375    
Ile Leu Asp Leu Thr Phe Thr Val Asn Glu Glu Val Phe Gly Gln Ile
            1380                1385                1390        
Thr Glu Arg Glu Leu Lys Pro Gly Gly Ala Asn Ile Pro Val Thr Glu
        1395                1400                1405            
Lys Asn Lys Lys Glu Tyr Ile Glu Arg Met Val Lys Trp Arg Ile Glu
    1410                1415                1420                
Arg Gly Val Val Gln Gln Thr Glu Ser Leu Val Arg Gly Phe Tyr Glu
1425                1430                1435                1440
Val Val Asp Ala Arg Leu Val Ser Val Phe Asp Ala Arg Glu Leu Glu
                1445                1450                1455    
Leu Val Ile Ala Gly Thr Ala Glu Ile Asp Leu Ser Asp Trp Arg Asn
            1460                1465                1470        
Asn Thr Glu Tyr Arg Gly Gly Tyr His Asp Asn His Ile Val Ile Arg
        1475                1480                1485            
Trp Phe Trp Ala Ala Val Glu Arg Phe Asn Asn Glu Gln Arg Leu Arg
    1490                1495                1500                
Leu Leu Gln Phe Val Thr Gly Thr Ser Ser Ile Pro Tyr Glu Gly Phe
1505                1510                1515                1520
Ala Ser Leu Arg Gly Ser Asn Gly Pro Arg Arg Phe Cys Val Glu Lys
                1525                1530                1535    
Trp Gly Lys Ile Thr Ala Leu Pro Arg Ala His Thr Cys Phe Asn Arg
            1540                1545                1550        
Leu Asp Leu Pro Pro Tyr Pro Ser Phe Ser Met Leu Tyr Glu Lys Leu
        1555                1560                1565            
Leu Thr Ala Val Glu Glu Thr Ser Thr Phe Gly Leu Glu
    1570                1575                1580    


<210> 5614
<211> 575
<212> PRT
<213> Homo sapiens

<400> 5614
Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser
 1               5                  10                  15      
Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu
            20                  25                  30          
Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr
        35                  40                  45              
Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro
    50                  55                  60                  
Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile
65                  70                  75                  80  
Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val
                85                  90                  95      
Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val
            100                 105                 110         
Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu
        115                 120                 125             
Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu
    130                 135                 140                 
Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys
145                 150                 155                 160 
Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu
                165                 170                 175     
Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn
            180                 185                 190         
Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val
        195                 200                 205             
Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly
    210                 215                 220                 
Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln
225                 230                 235                 240 
Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp
                245                 250                 255     
Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp
            260                 265                 270         
Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val
        275                 280                 285             
Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu
    290                 295                 300                 
Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val
305                 310                 315                 320 
Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala
                325                 330                 335     
Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val
            340                 345                 350         
Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg
        355                 360                 365             
Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp
    370                 375                 380                 
Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala
385                 390                 395                 400 
Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln
                405                 410                 415     
Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln
            420                 425                 430         
Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu
        435                 440                 445             
Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn
    450                 455                 460                 
Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly
465                 470                 475                 480 
Met Lys Val Ile Leu Val Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val
                485                 490                 495     
Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg
            500                 505                 510         
Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe
        515                 520                 525             
Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe
    530                 535                 540                 
Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Cys Arg Thr Ala Gly
545                 550                 555                 560 
Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly
                565                 570                 575 


<210> 5615
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 5615
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala
 1               5                  10                  15      
Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His
            20                  25                  30          
Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser
        35                  40                  45              
Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly
    50                  55                  60                  
Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu
65                  70                  75                  80  
His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His
                85                  90                  95      
Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala
            100                 105                 110         
Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu
        115                 120                 125             
Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr
    130                 135                 140                 
Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr
145                 150                 155                 160 
Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu
                165                 170                 175     
Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val
            180                 185                 190         
Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys
        195                 200                 205             
Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His
    210                 215                 220                 
Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser
225                 230                 235                 240 
Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro
                245                 250                 255     
Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser
            260                 265                 270         
Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro
        275                 280                 285             
Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr
    290                 295                 300                 
Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val
305                 310                 315                 320 
Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser
                325                 330                 335     
Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val
            340                 345                 350         
Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys
        355                 360                 365             
Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His
    370                 375                 380                 
Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys
385                 390                 395                 400 
Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro
                405                 410                 415     
Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met
            420                 425                 430         
Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln
        435                 440                 445             
Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly
    450                 455                 460                 
Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp
465                 470                 475                 480 
Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met
                485                 490                 495     
Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly
            500                 505                 510         
Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg
        515                 520                 525             
Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg
    530                 535                 540                 
Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly
545                 550                 555                 560 
Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val
                565                 570                 575     
Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe
            580                 585                 590         
Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys
        595                 600                 605             
Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly
    610                 615                 620                 
Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu
625                 630                 635                 640 
Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln
                645                 650                 655     
Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp
            660                 665                 670         
Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp
        675                 680                 685             
Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg
    690                 695                 700                 
Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu
705                 710                 715                 720 
Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala
                725                 730                 735     
Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly
            740                 745                 750         
Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg
        755                 760                 765             
Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg
    770                 775                 780                 
Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn
785                 790                 795                 800 
Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys
                805                 810                 815     
Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val
            820                 825                 830         
Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser
        835                 840                 845             
Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys
    850                 855                 860                 
Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala
865                 870                 875                 880 
Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val
                885                 890                 895     
Trp Thr Pro Val Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu
            900                 905                 910         
Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val
        915                 920                 925             
Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu
    930                 935                 940                 
Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala
945                 950                 955                 960 
Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr
                965                 970                 975     
Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp
            980                 985                 990         
Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys Ser
        995                 1000                1005            
Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro Cys
    1010                1015                1020                
Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg Arg Ser Val Ala Cys Val
1025                1030                1035                1040
Gln Leu Asp Gln Gly Gln Asp Val Glu Val Asp Glu Ala Ala Cys Ala
                1045                1050                1055    
Ala Leu Val Arg Pro Glu Ala Ser Val Pro Cys Leu Ile Ala Asp Cys
            1060                1065                1070        
Thr Tyr Arg Trp His Val Gly Thr Trp Met Glu Cys Ser Val Ser Cys
        1075                1080                1085            
Gly Asp Gly Ile Gln Arg Arg Arg Asp Thr Cys Leu Gly Pro Gln Ala
    1090                1095                1100                
Gln Ala Pro Val Pro Ala Asp Phe Cys Gln His Leu Pro Lys Pro Val
1105                1110                1115                1120
Thr Val Arg Gly Cys Trp Ala Gly Pro Cys Val Gly Gln Gly Thr Pro
                1125                1130                1135    
Ser Leu Val Pro His Glu Glu Ala Ala Ala Pro Gly Arg Thr Thr Ala
            1140                1145                1150        
Thr Pro Ala Gly Ala Ser Leu Glu Trp Ser Gln Ala Arg Gly Leu Leu
        1155                1160                1165            
Phe Ser Pro Ala Pro Gln Pro Arg Arg Leu Leu Pro Gly Pro Gln Glu
    1170                1175                1180                
Asn Ser Val Gln Ser Ser Ala Cys Gly Arg Gln His Leu Glu Pro Thr
1185                1190                1195                1200
Gly Thr Ile Asp Met Arg Gly Pro Gly Gln Ala Asp Cys Ala Val Ala
                1205                1210                1215    
Ile Gly Arg Pro Leu Gly Glu Val Val Thr Leu Arg Val Leu Glu Ser
            1220                1225                1230        
Ser Leu Asn Cys Ser Ala Gly Asp Met Leu Leu Leu Trp Gly Arg Leu
        1235                1240                1245            
Thr Trp Arg Lys Met Cys Arg Lys Leu Leu Asp Met Thr Phe Ser Ser
    1250                1255                1260                
Lys Thr Asn Thr Leu Val Val Arg Gln Arg Cys Gly Arg Pro Gly Gly
1265                1270                1275                1280
Gly Val Leu Leu Arg Tyr Gly Ser Gln Leu Ala Pro Glu Thr Phe Tyr
                1285                1290                1295    
Arg Glu Cys Asp Met Gln Leu Phe Gly Pro Trp Gly Glu Ile Val Ser
            1300                1305                1310        
Pro Ser Leu Ser Pro Ala Thr Ser Asn Ala Gly Gly Cys Arg Leu Phe
        1315                1320                1325            
Ile Asn Val Ala Pro His Ala Arg Ile Ala Ile His Ala Leu Ala Thr
    1330                1335                1340                
Asn Met Gly Ala Gly Thr Glu Gly Ala Asn Ala Ser Tyr Ile Leu Ile
1345                1350                1355                1360
Arg Asp Thr His Ser Leu Arg Thr Thr Ala Phe His Gly Gln Gln Val
                1365                1370                1375    
Leu Tyr Trp Glu Ser Glu Ser Ser Gln Ala Glu Met Glu Phe Ser Glu
            1380                1385                1390        
Gly Phe Leu Lys Ala Gln Ala Ser Leu Arg Gly Gln Tyr Trp Thr Leu
        1395                1400                1405            
Gln Ser Trp Val Pro Glu Met Gln Asp Pro Gln Ser Trp Lys Gly Lys
    1410                1415                1420                
Glu Gly Thr
1425        


<210> 5616
<211> 1371
<212> PRT
<213> Homo sapiens

<400> 5616
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala
 1               5                  10                  15      
Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His
            20                  25                  30          
Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser
        35                  40                  45              
Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly
    50                  55                  60                  
Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu
65                  70                  75                  80  
His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His
                85                  90                  95      
Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala
            100                 105                 110         
Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu
        115                 120                 125             
Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr
    130                 135                 140                 
Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr
145                 150                 155                 160 
Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu
                165                 170                 175     
Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val
            180                 185                 190         
Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys
        195                 200                 205             
Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His
    210                 215                 220                 
Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser
225                 230                 235                 240 
Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro
                245                 250                 255     
Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser
            260                 265                 270         
Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro
        275                 280                 285             
Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr
    290                 295                 300                 
Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val
305                 310                 315                 320 
Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser
                325                 330                 335     
Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val
            340                 345                 350         
Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys
        355                 360                 365             
Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His
    370                 375                 380                 
Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys
385                 390                 395                 400 
Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro
                405                 410                 415     
Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met
            420                 425                 430         
Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln
        435                 440                 445             
Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly
    450                 455                 460                 
Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp
465                 470                 475                 480 
Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met
                485                 490                 495     
Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly
            500                 505                 510         
Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg
        515                 520                 525             
Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg
    530                 535                 540                 
Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly
545                 550                 555                 560 
Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val
                565                 570                 575     
Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe
            580                 585                 590         
Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys
        595                 600                 605             
Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly
    610                 615                 620                 
Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu
625                 630                 635                 640 
Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln
                645                 650                 655     
Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp
            660                 665                 670         
Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp
        675                 680                 685             
Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg
    690                 695                 700                 
Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu
705                 710                 715                 720 
Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala
                725                 730                 735     
Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly
            740                 745                 750         
Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg
        755                 760                 765             
Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg
    770                 775                 780                 
Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn
785                 790                 795                 800 
Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys
                805                 810                 815     
Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val
            820                 825                 830         
Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser
        835                 840                 845             
Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys
    850                 855                 860                 
Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala
865                 870                 875                 880 
Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val
                885                 890                 895     
Trp Thr Pro Val Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu
            900                 905                 910         
Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val
        915                 920                 925             
Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu
    930                 935                 940                 
Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala
945                 950                 955                 960 
Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr
                965                 970                 975     
Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp
            980                 985                 990         
Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys Ser
        995                 1000                1005            
Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro Cys
    1010                1015                1020                
Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg Arg Ser Val Ala Cys Val
1025                1030                1035                1040
Gln Leu Asp Gln Gly Gln Asp Val Glu Val Asp Glu Ala Ala Cys Ala
                1045                1050                1055    
Ala Leu Val Arg Pro Glu Ala Ser Val Pro Cys Leu Ile Ala Asp Cys
            1060                1065                1070        
Thr Tyr Arg Trp His Val Gly Thr Trp Met Glu Cys Ser Val Ser Cys
        1075                1080                1085            
Gly Asp Gly Ile Gln Arg Arg Arg Asp Thr Cys Leu Gly Pro Gln Ala
    1090                1095                1100                
Gln Ala Pro Val Pro Ala Asp Phe Cys Gln His Leu Pro Lys Pro Val
1105                1110                1115                1120
Thr Val Arg Gly Cys Trp Ala Gly Pro Cys Val Gly Gln Gly Ala Cys
                1125                1130                1135    
Gly Arg Gln His Leu Glu Pro Thr Gly Thr Ile Asp Met Arg Gly Pro
            1140                1145                1150        
Gly Gln Ala Asp Cys Ala Val Ala Ile Gly Arg Pro Leu Gly Glu Val
        1155                1160                1165            
Val Thr Leu Arg Val Leu Glu Ser Ser Leu Asn Cys Ser Ala Gly Asp
    1170                1175                1180                
Met Leu Leu Leu Trp Gly Arg Leu Thr Trp Arg Lys Met Cys Arg Lys
1185                1190                1195                1200
Leu Leu Asp Met Thr Phe Ser Ser Lys Thr Asn Thr Leu Val Val Arg
                1205                1210                1215    
Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu Arg Tyr Gly Ser
            1220                1225                1230        
Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu Cys Asp Met Gln Leu Phe
        1235                1240                1245            
Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu Ser Pro Ala Thr Ser
    1250                1255                1260                
Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn Val Ala Pro His Ala Arg
1265                1270                1275                1280
Ile Ala Ile His Ala Leu Ala Thr Asn Met Gly Ala Gly Thr Glu Gly
                1285                1290                1295    
Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp Thr His Ser Leu Arg Thr
            1300                1305                1310        
Thr Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu Ser Glu Ser Ser
        1315                1320                1325            
Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys Ala Gln Ala Ser
    1330                1335                1340                
Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser Trp Val Pro Glu Met Gln
1345                1350                1355                1360
Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Thr
                1365                1370    


<210> 5617
<211> 1340
<212> PRT
<213> Homo sapiens

<400> 5617
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala
 1               5                  10                  15      
Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His
            20                  25                  30          
Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser
        35                  40                  45              
Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly
    50                  55                  60                  
Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu
65                  70                  75                  80  
His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His
                85                  90                  95      
Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala
            100                 105                 110         
Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu
        115                 120                 125             
Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr
    130                 135                 140                 
Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr
145                 150                 155                 160 
Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu
                165                 170                 175     
Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val
            180                 185                 190         
Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys
        195                 200                 205             
Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His
    210                 215                 220                 
Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser
225                 230                 235                 240 
Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro
                245                 250                 255     
Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser
            260                 265                 270         
Leu Leu Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala
        275                 280                 285             
Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu
    290                 295                 300                 
Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu
305                 310                 315                 320 
Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser
                325                 330                 335     
Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val
            340                 345                 350         
His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser
        355                 360                 365             
Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg
    370                 375                 380                 
Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu
385                 390                 395                 400 
Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser
                405                 410                 415     
Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly
            420                 425                 430         
Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly
        435                 440                 445             
Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile
    450                 455                 460                 
Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser
465                 470                 475                 480 
Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys
                485                 490                 495     
Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp
            500                 505                 510         
Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys
        515                 520                 525             
Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr
    530                 535                 540                 
Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu
545                 550                 555                 560 
Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly
                565                 570                 575     
Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp
            580                 585                 590         
Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg
        595                 600                 605             
Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile
    610                 615                 620                 
Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro
625                 630                 635                 640 
Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val
                645                 650                 655     
Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu
            660                 665                 670         
Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val
        675                 680                 685             
Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu
    690                 695                 700                 
Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe
705                 710                 715                 720 
Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val
                725                 730                 735     
Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala
            740                 745                 750         
Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys
        755                 760                 765             
Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser
    770                 775                 780                 
Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys
785                 790                 795                 800 
Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly
                805                 810                 815     
Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser
            820                 825                 830         
Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys
        835                 840                 845             
Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His
    850                 855                 860                 
Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly
865                 870                 875                 880 
Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro
                885                 890                 895     
Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg
            900                 905                 910         
Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu
        915                 920                 925             
Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu
    930                 935                 940                 
Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu
945                 950                 955                 960 
Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys
                965                 970                 975     
Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro
            980                 985                 990         
Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg Arg Ser Val Ala Cys
        995                 1000                1005            
Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val Asp Glu Ala Ala Cys
    1010                1015                1020                
Ala Ala Leu Val Arg Pro Glu Ala Ser Val Pro Cys Leu Ile Ala Asp
1025                1030                1035                1040
Cys Thr Tyr Arg Trp His Val Gly Thr Trp Met Glu Cys Ser Val Ser
                1045                1050                1055    
Cys Gly Asp Gly Ile Gln Arg Arg Arg Asp Thr Cys Leu Gly Pro Gln
            1060                1065                1070        
Ala Gln Ala Pro Val Pro Ala Asp Phe Cys Gln His Leu Pro Lys Pro
        1075                1080                1085            
Val Thr Val Arg Gly Cys Trp Ala Gly Pro Cys Val Gly Gln Gly Ala
    1090                1095                1100                
Cys Gly Arg Gln His Leu Glu Pro Thr Gly Thr Ile Asp Met Arg Gly
1105                1110                1115                1120
Pro Gly Gln Ala Asp Cys Ala Val Ala Ile Gly Arg Pro Leu Gly Glu
                1125                1130                1135    
Val Val Thr Leu Arg Val Leu Glu Ser Ser Leu Asn Cys Ser Ala Gly
            1140                1145                1150        
Asp Met Leu Leu Leu Trp Gly Arg Leu Thr Trp Arg Lys Met Cys Arg
        1155                1160                1165            
Lys Leu Leu Asp Met Thr Phe Ser Ser Lys Thr Asn Thr Leu Val Val
    1170                1175                1180                
Arg Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu Arg Tyr Gly
1185                1190                1195                1200
Ser Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu Cys Asp Met Gln Leu
                1205                1210                1215    
Phe Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu Ser Pro Ala Thr
            1220                1225                1230        
Ser Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn Val Ala Pro His Ala
        1235                1240                1245            
Arg Ile Ala Ile His Ala Leu Ala Thr Asn Met Gly Ala Gly Thr Glu
    1250                1255                1260                
Gly Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp Thr His Ser Leu Arg
1265                1270                1275                1280
Thr Thr Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu Ser Glu Ser
                1285                1290                1295    
Ser Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys Ala Gln Ala
            1300                1305                1310        
Ser Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser Trp Val Pro Glu Met
        1315                1320                1325            
Gln Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Thr
    1330                1335                1340


<210> 5618
<211> 784
<212> PRT
<213> Homo sapiens

<400> 5618
Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly
 1               5                  10                  15      
Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln
            20                  25                  30          
Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp
        35                  40                  45              
Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu
    50                  55                  60                  
Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala
65                  70                  75                  80  
Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp
                85                  90                  95      
Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn
            100                 105                 110         
Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly
        115                 120                 125             
Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val
    130                 135                 140                 
Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val
145                 150                 155                 160 
Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val
                165                 170                 175     
Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln
            180                 185                 190         
Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile
        195                 200                 205             
Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu
    210                 215                 220                 
Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly
225                 230                 235                 240 
Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro
                245                 250                 255     
Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg
            260                 265                 270         
Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro
        275                 280                 285             
Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp
    290                 295                 300                 
Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys
305                 310                 315                 320 
Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile
                325                 330                 335     
Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro
            340                 345                 350         
Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu
        355                 360                 365             
Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn
    370                 375                 380                 
Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala
385                 390                 395                 400 
Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly
                405                 410                 415     
Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu
            420                 425                 430         
Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys
        435                 440                 445             
Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln
    450                 455                 460                 
Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala
465                 470                 475                 480 
Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu
                485                 490                 495     
Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val
            500                 505                 510         
Lys Phe Lys Phe Thr Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp
        515                 520                 525             
Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp
    530                 535                 540                 
Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn
545                 550                 555                 560 
Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys
                565                 570                 575     
Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala
            580                 585                 590         
Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile
        595                 600                 605             
Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu
    610                 615                 620                 
Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu
625                 630                 635                 640 
Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr
                645                 650                 655     
Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys
            660                 665                 670         
Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val
        675                 680                 685             
Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu
    690                 695                 700                 
Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly
705                 710                 715                 720 
Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser
                725                 730                 735     
Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp
            740                 745                 750         
Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys
        755                 760                 765             
Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr
    770                 775                 780                 


<210> 5619
<211> 420
<212> PRT
<213> Homo sapiens

<400> 5619
Met Pro Phe Ser Val Ser Trp Gly Val Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Ser Ser Leu Val Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Gly Asp Trp Glu Asp Leu
        35                  40                  45              
Ala Cys Gln Lys Ile Ser Tyr Asn Val Thr Asp Leu Ala Phe Asp Leu
    50                  55                  60                  
Tyr Lys Ser Trp Leu Ile Tyr His Asn Gln His Val Leu Val Thr Pro
65                  70                  75                  80  
Thr Ser Val Ala Met Ala Phe Arg Met Leu Ser Leu Gly Thr Lys Ala
                85                  90                  95      
Asp Thr Arg Thr Glu Ile Leu Glu Gly Leu Asn Val Asn Leu Thr Glu
            100                 105                 110         
Thr Pro Glu Ala Lys Ile His Glu Cys Phe Gln Gln Val Leu Gln Ala
        115                 120                 125             
Leu Ser Arg Pro Asp Thr Arg Leu Gln Leu Thr Thr Gly Ser Ser Leu
    130                 135                 140                 
Phe Val Asn Lys Ser Met Lys Leu Val Asp Thr Phe Leu Glu Asp Thr
145                 150                 155                 160 
Lys Lys Leu Tyr His Ser Glu Ala Ser Ser Ile Asn Phe Arg Asp Thr
                165                 170                 175     
Glu Glu Ala Lys Glu Gln Ile Asn Asn Tyr Val Glu Lys Arg Thr Gly
            180                 185                 190         
Arg Lys Val Val Asp Leu Val Lys His Leu Lys Lys Asp Thr Ser Leu
        195                 200                 205             
Ala Leu Val Asp Tyr Ile Ser Phe His Gly Lys Trp Lys Asp Lys Phe
    210                 215                 220                 
Lys Ala Glu Arg Ile Met Val Glu Gly Phe His Val Asp Asp Lys Thr
225                 230                 235                 240 
Ile Ile Arg Val Pro Met Ile Asn His Leu Gly Arg Phe Asp Ile His
                245                 250                 255     
Arg Asp Arg Glu Leu Ser Ser Trp Val Leu Ala Gln His Tyr Val Gly
            260                 265                 270         
Asn Ala Thr Ala Phe Phe Ile Leu Pro Asp Pro Lys Lys Met Trp Gln
        275                 280                 285             
Leu Glu Glu Lys Leu Thr Tyr Ser His Leu Glu Asn Ile Gln Arg Ala
    290                 295                 300                 
Phe Asp Ile Arg Ser Ile Asn Leu His Phe Pro Lys Leu Ser Ile Ser
305                 310                 315                 320 
Gly Thr Tyr Lys Leu Lys Arg Val Pro Arg Asn Leu Gly Ile Thr Lys
                325                 330                 335     
Ile Phe Ser Asn Glu Ala Asp Leu Ser Gly Val Ser Gln Glu Ala Pro
            340                 345                 350         
Leu Lys Leu Ser Lys Ala Val His Val Ala Val Leu Thr Ile Asp Glu
        355                 360                 365             
Lys Gly Thr Glu Ala Thr Gly Ala Pro His Leu Glu Glu Lys Ala Trp
    370                 375                 380                 
Ser Lys Tyr Gln Thr Val Met Phe Asn Arg Pro Phe Leu Val Ile Ile
385                 390                 395                 400 
Lys Glu Tyr Ile Thr Asn Phe Pro Leu Phe Ile Gly Lys Val Val Asn
                405                 410                 415     
Pro Thr Gln Lys
            420 


<210> 5620
<211> 120
<212> PRT
<213> Homo sapiens

<400> 5620
Met Gly Thr Asn Phe Pro Phe Trp Val Ser Gln Leu Thr Phe Phe Lys
 1               5                  10                  15      
Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu
            20                  25                  30          
Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly Val Thr
        35                  40                  45              
Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala Val Leu
    50                  55                  60                  
Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe Leu Glu
65                  70                  75                  80  
Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe
                85                  90                  95      
Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe Met Gly
            100                 105                 110         
Lys Val Val Asn Pro Thr Gln Lys
        115                 120 


<210> 5621
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 5621
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys
 1               5                  10                  15      
Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp
            20                  25                  30          
Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu
        35                  40                  45              
Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala
    50                  55                  60                  
Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp
65                  70                  75                  80  
Ala Val Arg Thr Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln
                85                  90                  95      
Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His
            100                 105                 110         
Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu
        115                 120                 125             
Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu
    130                 135                 140                 
Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val
145                 150                 155                 160 
Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn
                165                 170                 175     
Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala
            180                 185                 190         
Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe
        195                 200                 205             
Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu
    210                 215                 220                 
Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu
225                 230                 235                 240 
Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr
                245                 250                 255     
Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile
            260                 265                 270         
Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg
        275                 280                 285             
Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu
    290                 295                 300                 
Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His
305                 310                 315                 320 
Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys
                325                 330                 335     
Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser
            340                 345                 350         
Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys
        355                 360                 365             
Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro
    370                 375                 380                 
Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln
385                 390                 395                 400 
Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser
                405                 410                 415     
Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe
            420                 425                 430         
Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser
        435                 440                 445             
Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser
    450                 455                 460                 
Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu
465                 470                 475                 480 
Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly
                485                 490                 495     
Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val
            500                 505                 510         
Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly
        515                 520                 525             
Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln
    530                 535                 540                 
Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val
545                 550                 555                 560 
Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro
                565                 570                 575     
Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys
            580                 585                 590         
Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys
        595                 600                 605             
Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe
    610                 615                 620                 
Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn
625                 630                 635                 640 
Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp
                645                 650                 655     
Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro
            660                 665                 670         
Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile
        675                 680                 685             
Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val
    690                 695                 700                 
Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn
705                 710                 715                 720 
Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp
                725                 730                 735     
Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp
            740                 745                 750         
Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp
        755                 760                 765             
Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp
    770                 775                 780                 
Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp
785                 790                 795                 800 
Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val
                805                 810                 815     
Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln
            820                 825                 830         
Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp
        835                 840                 845             
Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu
    850                 855                 860                 
Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala
865                 870                 875                 880 
Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His
                885                 890                 895     
Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu
            900                 905                 910         
Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp
        915                 920                 925             
Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp
    930                 935                 940                 
Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe
945                 950                 955                 960 
Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn
                965                 970                 975     
Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys
            980                 985                 990         
Asp Pro Gly Leu Ala Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe
        995                 1000                1005            
Ser Gly Thr Phe Phe Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly
    1010                1015                1020                
Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp
1025                1030                1035                1040
Lys Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln
                1045                1050                1055    
Gly Tyr Ser Gly Leu Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro
            1060                1065                1070        
Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly
        1075                1080                1085            
Gln Val Arg Thr Leu Trp His Asp Pro Arg His Ile Gly Trp Lys Asp
    1090                1095                1100                
Phe Thr Ala Tyr Arg Trp Arg Leu Ser His Arg Pro Lys Thr Gly Phe
1105                1110                1115                1120
Ile Arg Val Val Met Tyr Glu Gly Lys Lys Ile Met Ala Asp Ser Gly
                1125                1130                1135    
Pro Ile Tyr Asp Lys Thr Tyr Ala Gly Gly Arg Leu Gly Leu Phe Val
            1140                1145                1150        
Phe Ser Gln Glu Met Val Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg
        1155                1160                1165            
Asp Pro
    1170


<210> 5622
<211> 275
<212> PRT
<213> Homo sapiens

<400> 5622
Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu
 1               5                  10                  15      
Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg
            20                  25                  30          
Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys
        35                  40                  45              
Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu
    50                  55                  60                  
Asn Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val
65                  70                  75                  80  
Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser
                85                  90                  95      
Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro
            100                 105                 110         
Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys
        115                 120                 125             
Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser
    130                 135                 140                 
Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr
145                 150                 155                 160 
Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn
                165                 170                 175     
Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala
            180                 185                 190         
Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser
        195                 200                 205             
Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met
    210                 215                 220                 
Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr
225                 230                 235                 240 
Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg
                245                 250                 255     
Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala
            260                 265                 270         
Phe Arg Pro
        275 


<210> 5623
<211> 1337
<212> PRT
<213> Homo sapiens

<400> 5623
Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly
 1               5                  10                  15      
Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln
            20                  25                  30          
Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val
        35                  40                  45              
Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr
    50                  55                  60                  
Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu
65                  70                  75                  80  
Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu
                85                  90                  95      
Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys
            100                 105                 110         
Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val
        115                 120                 125             
Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr
    130                 135                 140                 
Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu
145                 150                 155                 160 
Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu
                165                 170                 175     
Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn
            180                 185                 190         
Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile
        195                 200                 205             
Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala
    210                 215                 220                 
Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu
225                 230                 235                 240 
Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln
                245                 250                 255     
Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro
            260                 265                 270         
Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu
        275                 280                 285             
Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro
    290                 295                 300                 
Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser
305                 310                 315                 320 
Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu
                325                 330                 335     
Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly
            340                 345                 350         
Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln
        355                 360                 365             
Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu
    370                 375                 380                 
Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys
385                 390                 395                 400 
Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu
                405                 410                 415     
Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile
            420                 425                 430         
Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu
        435                 440                 445             
Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val
    450                 455                 460                 
Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu
465                 470                 475                 480 
Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val
                485                 490                 495     
Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly
            500                 505                 510         
Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu
        515                 520                 525             
Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe
    530                 535                 540                 
Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp
545                 550                 555                 560 
Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu
                565                 570                 575     
Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr
            580                 585                 590         
Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro
        595                 600                 605             
Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr
    610                 615                 620                 
Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala
625                 630                 635                 640 
Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser
                645                 650                 655     
Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln
            660                 665                 670         
Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile
        675                 680                 685             
Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly
    690                 695                 700                 
Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala
705                 710                 715                 720 
Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu
                725                 730                 735     
Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu
            740                 745                 750         
Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys
        755                 760                 765             
Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn
    770                 775                 780                 
Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys
785                 790                 795                 800 
Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro
                805                 810                 815     
Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser
            820                 825                 830         
Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys
        835                 840                 845             
Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala
    850                 855                 860                 
Asp Val Leu Lys Tyr Thr Tyr Asp Asp Phe Lys Lys Gly Ala Ser Asp
865                 870                 875                 880 
Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln
                885                 890                 895     
Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser
            900                 905                 910         
Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr
        915                 920                 925             
Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn
    930                 935                 940                 
Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr
945                 950                 955                 960 
Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly Ala
                965                 970                 975     
Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly Gly
            980                 985                 990         
Phe Ile Phe Trp Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu Val
        995                 1000                1005            
Ser Phe Ser Gln Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val Glu
    1010                1015                1020                
Asn Phe Glu Ala Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys Gly
1025                1030                1035                1040
Phe Ala Glu Glu Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln Pro
                1045                1050                1055    
Lys Tyr Ala Ala Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr Asn
            1060                1065                1070        
Asn Val Leu Pro Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln Thr
        1075                1080                1085            
His Ser Thr Asp Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr His
    1090                1095                1100                
Ser Lys Lys Asp Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr Leu
1105                1110                1115                1120
Lys Asp Phe Trp Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile Ile
                1125                1130                1135    
Met Leu Thr Lys Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu Tyr
            1140                1145                1150        
Trp Pro Ser Lys Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala Met
        1155                1160                1165            
Thr Ser Glu Ile Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr Val
    1170                1175                1180                
Lys Asn Ile Gln Thr Ser Glu Ser His Pro Leu Arg Gln Phe His Phe
1185                1190                1195                1200
Thr Ser Trp Pro Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu Ile
                1205                1210                1215    
Asn Phe Arg Tyr Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro Glu
            1220                1225                1230        
Ser Pro Ile Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr
        1235                1240                1245            
Phe Ile Ala Ile Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn Thr
    1250                1255                1260                
Val Asp Val Tyr Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro Leu
1265                1270                1275                1280
Met Val Gln Thr Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val Leu
                1285                1290                1295    
Asp Ile Val Arg Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr Gln
            1300                1305                1310        
Asn Thr Thr Ala Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr Thr
        1315                1320                1325            
Phe Gly Lys Thr Asn Gly Tyr Ile Ala
    1330                1335        


<210> 5624
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 5624
Ser Ser Leu Arg Leu Trp Asp Gly Lys Leu Leu Ser Ser Asp Val Thr
 1               5                  10                  15      
His Tyr Val Ile Pro Asp Trp Lys Val Val Gln Asp Tyr Leu Glu Ile
            20                  25                  30          
Leu Glu Phe Pro Glu Leu Lys Gly Ile Ile Phe Met Gln Thr Ala Cys
        35                  40                  45              
Gln Ala Val Gln His Gln Arg Gly Arg Arg Gln Tyr Asn Lys Leu Arg
    50                  55                  60                  
Asn Leu Leu Lys Asp Ala Arg His Asp Cys Ile Leu Phe Ala Asn Glu
65                  70                  75                  80  
Phe Gln Gln Cys Cys Tyr Leu Pro Arg Glu Arg Gly Glu Ser Met Glu
                85                  90                  95      
Lys Trp Gln Thr Arg Ser Ile Tyr Asn Ala Ala Val Trp Tyr Tyr His
            100                 105                 110         
His Cys Gln Asp Arg Met Pro Ile Val Met Val Thr Glu Asp Glu Glu
        115                 120                 125             
Ala Ile Gln Gln Tyr Gly Ser Glu Thr Glu Gly Val Phe Val Ile Thr
    130                 135                 140                 
Phe Lys Asn Tyr Leu Asp Asn Phe Trp Pro Asp Leu Lys Ala Ala His
145                 150                 155                 160 
Glu Leu Cys Asp Ser Ile Leu Gln Ser Arg Arg Glu Arg Glu Asn Glu
                165                 170                 175     
Ser Gln Glu Ser His Gly Lys Glu Tyr Pro Glu His Leu Pro Leu Glu
            180                 185                 190         
Val Leu Glu Ala Gly Ile Lys Ser Gly Arg Tyr Ile Gln Gly Ile Leu
        195                 200                 205             
Asn Val Asn Lys His Arg Ala Gln Ile Glu Ala Phe Val Arg Leu Gln
    210                 215                 220                 
Gly Ala Ser Ser Lys Asp Ser Asp Leu Val Ser Asp Ile Leu Ile His
225                 230                 235                 240 
Gly Met Lys Ala Arg Asn Arg Ser Ile His Gly Asp Val Val Val Val
                245                 250                 255     
Glu Leu Leu Pro Lys Asn Glu Trp Lys Gly Arg Thr Val Ala Leu Cys
            260                 265                 270         
Glu Asn Asp Cys Asp Asp Lys Ala Ser Gly Glu Ser Pro Ser Glu Pro
        275                 280                 285             
Met Pro Thr Gly Arg Val Val Gly Ile Leu Gln Lys Asn Trp Arg Asp
    290                 295                 300                 
Tyr Val Val Thr Phe Pro Ser Lys Glu Glu Val Gln Ser Gln Gly Lys
305                 310                 315                 320 
Asn Ala Gln Lys Ile Leu Val Thr Pro Trp Asp Tyr Arg Ile Pro Lys
                325                 330                 335     
Ile Arg Ile Ser Thr Gln Gln Ala Glu Thr Leu Gln Asp Phe Arg Val
            340                 345                 350         
Val Val Arg Ile Asp Ser Trp Glu Ser Thr Ser Val Tyr Pro Asn Gly
        355                 360                 365             
His Phe Val Arg Val Leu Gly Arg Ile Gly Asp Leu Glu Gly Glu Ile
    370                 375                 380                 
Ala Thr Ile Leu Val Glu Asn Ser Ile Ser Val Ile Pro Phe Ser Glu
385                 390                 395                 400 
Ala Gln Met Cys Glu Met Pro Val Asn Thr Pro Glu Ser Pro Trp Lys
                405                 410                 415     
Val Ser Pro Glu Glu Glu Gln Lys Arg Lys Asp Leu Arg Lys Ser His
            420                 425                 430         
Leu Val Phe Ser Ile Asp Pro Lys Gly Cys Glu Asp Val Asp Asp Thr
        435                 440                 445             
Leu Ser Val Arg Thr Leu Asn Asn Gly Asn Leu Glu Leu Gly Val His
    450                 455                 460                 
Ile Ala Asp Val Thr His Phe Val Ala Pro Asn Ser Tyr Ile Asp Ile
465                 470                 475                 480 
Glu Ala Arg Thr Arg Ala Thr Thr Tyr Tyr Leu Ala Asp Arg Arg Tyr
                485                 490                 495     
Asp Met Leu Pro Ser Val Leu Ser Ala Asp Leu Cys Ser Leu Leu Gly
            500                 505                 510         
Gly Val Asp Arg Tyr Ala Val Ser Ile Met Trp Glu Leu Asp Lys Ala
        515                 520                 525             
Ser Tyr Glu Ile Lys Lys Val Trp Tyr Gly Arg Thr Ile Ile Arg Ser
    530                 535                 540                 
Ala Tyr Lys Leu Phe Tyr Glu Ala Ala Gln Glu Leu Leu Asp Gly Asn
545                 550                 555                 560 
Leu Ser Val Val Asp Asp Ile Pro Glu Phe Lys Asp Leu Asp Glu Lys
                565                 570                 575     
Ser Arg Gln Ala Lys Leu Glu Glu Leu Val Trp Ala Ile Gly Lys Leu
            580                 585                 590         
Thr Asp Ile Ala Arg His Val Arg Ala Lys Arg Asp Gly Cys Gly Ala
        595                 600                 605             
Leu Glu Leu Glu Gly Val Glu Val Cys Val Gln Leu Asp Asp Lys Lys
    610                 615                 620                 
Asn Ile His Asp Leu Ile Pro Lys Gln Pro Leu Glu Val His Glu Thr
625                 630                 635                 640 
Val Ala Glu Cys Met Ile Leu Ala Asn His Trp Val Ala Lys Lys Ile
                645                 650                 655     
Trp Glu Ser Phe Pro His Gln Ala Leu Leu Arg Gln His Pro Pro Pro
            660                 665                 670         
His Gln Glu Phe Phe Ser Glu Leu Arg Glu Cys Ala Lys Ala Lys Gly
        675                 680                 685             
Phe Phe Ile Asp Thr Arg Ser Asn Lys Thr Leu Ala Asp Ser Leu Asp
    690                 695                 700                 
Asn Ala Asn Asp Pro His Asp Pro Ile Val Asn Arg Leu Leu Arg Ser
705                 710                 715                 720 
Met Ala Thr Gln Ala Met Ser Asn Ala Leu Tyr Phe Ser Thr Gly Ser
                725                 730                 735     
Cys Ala Glu Glu Glu Phe His His Tyr Gly Leu Ala Leu Asp Lys Tyr
            740                 745                 750         
Thr His Phe Thr Ser Pro Ile Arg Arg Tyr Ser Asp Ile Val Val His
        755                 760                 765             
Arg Leu Leu Met Ala Ala Ile Ser Lys Asp Lys Lys Met Glu Ile Lys
    770                 775                 780                 
Gly Asn Leu Phe Ser Asn Lys Asp Leu Glu Glu Leu Cys Arg His Ile
785                 790                 795                 800 
Asn Asn Arg Asn Gln Ala Ala Gln His Ser Gln Lys Gln Ser Thr Glu
                805                 810                 815     
Leu Phe Gln Cys Met Tyr Phe Lys Asp Lys Asp Pro Ala Thr Glu Glu
            820                 825                 830         
Arg Cys Ile Ser Asp Gly Val Ile Tyr Ser Ile Arg Thr Asn Gly Val
        835                 840                 845             
Leu Leu Phe Ile Pro Arg Phe Gly Ile Lys Gly Ala Ala Tyr Leu Lys
    850                 855                 860                 
Asn Lys Asp Gly Leu Val Ile Ser Cys Gly Pro Asp Ser Cys Ser Glu
865                 870                 875                 880 
Trp Lys Pro Gly Ser Leu Gln Arg Phe Gln Asn Lys Ile Thr Ser Thr
                885                 890                 895     
Thr Thr Asp Gly Glu Ser Val Thr Phe His Leu Phe Asp His Val Thr
            900                 905                 910         
Val Arg Ile Ser Ile Gln Ala Ser Arg Cys His Ser Asp Thr Ile Arg
        915                 920                 925             
Leu Glu Ile Ile Ser Asn Lys Pro Tyr Lys Ile Pro Asn Thr Glu Leu
    930                 935                 940                 
Ile His Gln Ser Ser Pro Leu Leu Lys Ser Glu Leu Val Lys Glu Val
945                 950                 955                 960 
Thr Lys Ser Val Glu Glu Ala Gln Leu Ala Gln Glu Val Lys Val Asn
                965                 970                 975     
Ile Ile Gln Glu Glu Tyr Gln Glu Tyr Arg Gln Thr Lys Gly Arg Ser
            980                 985                 990         
Leu Tyr Thr Leu Leu Glu Glu Ile Arg Asp Leu Ala Leu Leu Asp Val
        995                 1000                1005            
Ser Asn Asn Tyr Gly Ile
    1010                


<210> 5625
<211> 315
<212> PRT
<213> Homo sapiens

<400> 5625
Thr Arg Pro Pro Glu Arg Ala Met Asp Ala Leu Lys Ser Ala Gly Arg
 1               5                  10                  15      
Ala Leu Ile Arg Ser Pro Ser Leu Ala Lys Gln Ser Trp Gly Gly Gly
            20                  25                  30          
Gly Arg His Arg Lys Leu Pro Glu Asn Trp Thr Asp Thr Arg Glu Thr
        35                  40                  45              
Leu Leu Glu Gly Met Leu Phe Ser Leu Lys Tyr Leu Gly Met Thr Leu
    50                  55                  60                  
Val Glu Gln Pro Lys Gly Glu Glu Leu Ser Ala Ala Ala Ile Lys Arg
65                  70                  75                  80  
Ile Val Ala Thr Ala Lys Ala Ser Gly Lys Lys Leu Gln Lys Val Thr
                85                  90                  95      
Leu Lys Val Ser Pro Arg Gly Ile Ile Leu Thr Asp Asn Leu Thr Asn
            100                 105                 110         
Gln Leu Ile Glu Asn Val Ser Ile Tyr Arg Ile Ser Tyr Cys Thr Ala
        115                 120                 125             
Asp Lys Met His Asp Lys Val Phe Ala Tyr Ile Ala Gln Ser Gln His
    130                 135                 140                 
Asn Gln Ser Leu Glu Cys His Ala Phe Leu Cys Thr Lys Arg Lys Met
145                 150                 155                 160 
Ala Gln Ala Val Thr Leu Thr Val Ala Gln Ala Phe Lys Val Ala Phe
                165                 170                 175     
Glu Phe Trp Gln Val Ser Lys Glu Glu Lys Glu Lys Arg Asp Lys Ala
            180                 185                 190         
Ser Gln Glu Gly Gly Asp Val Leu Gly Ala Arg Gln Asp Cys Thr Pro
        195                 200                 205             
Pro Leu Lys Ser Leu Val Ala Thr Gly Asn Leu Leu Asp Leu Glu Glu
    210                 215                 220                 
Thr Ala Lys Ala Pro Leu Ser Thr Val Ser Ala Asn Thr Thr Asn Met
225                 230                 235                 240 
Asp Glu Val Pro Arg Pro Gln Ala Leu Ser Gly Ser Ser Val Val Trp
                245                 250                 255     
Glu Leu Asp Asp Gly Leu Asp Glu Ala Phe Ser Arg Leu Ala Gln Ser
            260                 265                 270         
Arg Thr Asn Pro Gln Val Leu Asp Thr Gly Leu Thr Ala Gln Asp Met
        275                 280                 285             
His Tyr Ala Gln Cys Leu Ser Pro Val Asp Trp Asp Lys Pro Asp Ser
    290                 295                 300                 
Ser Gly Thr Glu Gln Asp Asp Leu Phe Ser Phe
305                 310                 315 


<210> 5626
<211> 221
<212> PRT
<213> Homo sapiens

<400> 5626
Met Leu Phe Ser Leu Lys Tyr Leu Gly Met Thr Leu Val Glu Gln Pro
 1               5                  10                  15      
Lys Gly Glu Glu Leu Ser Ala Ala Ala Ile Lys Arg Ile Val Ala Thr
            20                  25                  30          
Ala Lys Ala Ser Gly Lys Lys Leu Gln Lys Val Thr Leu Lys Val Ser
        35                  40                  45              
Pro Arg Gly Ile Ile Leu Thr Asp Asn Leu Thr Asn Gln Leu Ile Glu
    50                  55                  60                  
Asn Val Ser Ile Tyr Arg Ile Ser Tyr Cys Thr Ala Asp Lys Met His
65                  70                  75                  80  
Asp Lys Val Phe Ala Tyr Ile Ala Gln Ser Gln His Asn Gln Ser Leu
                85                  90                  95      
Glu Cys His Ala Phe Leu Cys Thr Lys Arg Lys Met Ala Gln Ala Val
            100                 105                 110         
Thr Leu Thr Val Ala Gln Ala Phe Lys Val Ala Phe Glu Phe Trp Gln
        115                 120                 125             
Val Ser Lys Glu Glu Lys Glu Lys Arg Asp Lys Ala Ser Gln Glu Gly
    130                 135                 140                 
Gly Asp Val Leu Gly Ala Arg Gln Asp Cys Thr Pro Pro Leu Lys Ser
145                 150                 155                 160 
Leu Val Ala Thr Gly Asn Leu Leu Asp Leu Glu Glu Thr Ala Lys Ala
                165                 170                 175     
Pro Leu Ser Thr Val Ser Ala Asn Thr Thr Asn Met Asp Glu Val Pro
            180                 185                 190         
Arg Pro Gln Ala Leu Ser Gly Ser Ser Val Val Trp Val Ser Gly Cys
        195                 200                 205             
Val Ala Ser Arg Ser Val Ile Leu Ser Leu Thr Ser Gly
    210                 215                 220     


<210> 5627
<211> 696
<212> PRT
<213> Homo sapiens

<400> 5627
Pro Thr Gln Ser Thr Arg Arg Ile Ala Thr Val Ser Ile Ala Ala Ala
 1               5                  10                  15      
Val Ala Pro Leu Thr Leu Phe Leu Tyr Arg Gly Asp Gly Gly Leu Ser
            20                  25                  30          
Ser Arg Arg Arg Ala Asp Ala Ala Ala Gly Ala Leu Cys Gly Glu Val
        35                  40                  45              
Ala Val Lys Pro Pro Ile Asn Pro Phe Thr Glu Phe Met Glu Lys Ala
    50                  55                  60                  
Val Asn Asp Gly Ser His Ser Glu Glu Leu Phe Cys His Leu Lys Thr
65                  70                  75                  80  
Ile Ser Glu Lys Glu Asp Leu Pro Arg Cys Thr Ser Glu Ser His Leu
                85                  90                  95      
Ser Cys Leu Lys Gln Asp Ile Leu Asn Glu Lys Thr Glu Leu Glu Ala
            100                 105                 110         
Thr Leu Lys Glu Ala Glu Leu Val Thr His Ser Val Glu Leu Leu Leu
        115                 120                 125             
Pro Leu Phe Lys Asp Thr Ile Glu Lys Ile Asn Phe Glu Asn Ala Asn
    130                 135                 140                 
Leu Ser Ala Leu Asn Leu Lys Ile Ser Glu Gln Lys Glu Ile Leu Ile
145                 150                 155                 160 
Lys Glu Leu Asp Thr Phe Lys Ser Val Lys Leu Ala Leu Glu His Leu
                165                 170                 175     
Leu Arg Lys Arg Asp Tyr Lys Gln Thr Gly Asp Asn Leu Ser Ser Met
            180                 185                 190         
Leu Leu Glu Asn Leu Thr Asp Asn Glu Ser Glu Asn Thr Asn Leu Lys
        195                 200                 205             
Lys Lys Val Phe Glu Lys Glu Ala His Ile Gln Glu Leu Ser Cys Leu
    210                 215                 220                 
Phe Gln Ser Glu Lys Ala Asn Thr Leu Lys Ala Asn Arg Phe Ser Gln
225                 230                 235                 240 
Ser Val Lys Val Val His Glu Arg Leu Gln Ile Gln Ile His Lys Arg
                245                 250                 255     
Glu Ala Glu Asn Asp Lys Leu Lys Glu Tyr Val Lys Ser Leu Glu Thr
            260                 265                 270         
Lys Ile Ala Lys Trp Asn Leu Gln Ser Arg Met Asn Lys Asn Glu Ala
        275                 280                 285             
Ile Val Met Lys Glu Ala Ser Arg Gln Lys Thr Val Ala Leu Lys Lys
    290                 295                 300                 
Ala Ser Lys Val Tyr Lys Gln Arg Leu Asp His Phe Thr Gly Ala Ile
305                 310                 315                 320 
Glu Lys Leu Thr Ser Gln Ile Arg Asp Gln Glu Ala Lys Leu Ser Glu
                325                 330                 335     
Thr Ile Ser Ala Ser Asn Ala Trp Lys Ser His Tyr Glu Lys Ile Val
            340                 345                 350         
Ile Glu Lys Thr Glu Leu Glu Val Gln Ile Glu Thr Met Lys Lys Gln
        355                 360                 365             
Ile Ile Asn Leu Leu Glu Asp Leu Lys Lys Met Glu Asp His Gly Lys
    370                 375                 380                 
Asn Ser Cys Glu Glu Ile Leu Arg Lys Val His Ser Ile Glu His Glu
385                 390                 395                 400 
Asn Glu Thr Leu Asn Leu Glu Asn Thr Lys Leu Lys Leu Arg Phe Pro
                405                 410                 415     
Cys Arg Ile Thr Glu Ser Lys Asn Met Asn Ile Leu Ile Val Leu Asp
            420                 425                 430         
Met Leu Cys Tyr Ile Ser Ser Glu Lys Thr Thr Leu Ala Ala Leu Lys
        435                 440                 445             
Asp Glu Val Val Ser Val Glu Asn Glu Leu Ser Glu Leu Gln Glu Val
    450                 455                 460                 
Glu Lys Lys Gln Lys Thr Leu Ile Glu Met Tyr Lys Thr Gln Val Gln
465                 470                 475                 480 
Lys Leu Gln Glu Ala Ala Glu Ile Val Lys Ser Arg Cys Glu Asn Leu
                485                 490                 495     
Leu His Lys Asn Asn Gln Ile Thr Lys Thr Lys Asn Lys Asn Val Glu
            500                 505                 510         
Lys Met Arg Gly Gln Met Glu Ser His Leu Lys Glu Leu Glu Arg Val
        515                 520                 525             
Cys Asp Ser Leu Thr Ala Ala Glu Arg Arg Leu His Glu Cys Gln Glu
    530                 535                 540                 
Ser Leu Gln Cys Cys Lys Gly Lys Cys Ala Asp Gln Glu His Thr Ile
545                 550                 555                 560 
Arg Glu Leu Gln Gly Gln Val Asp Gly Asn His Asn Leu Leu Thr Lys
                565                 570                 575     
Leu Ser Leu Glu Glu Glu Asn Cys Leu Ile Gln Leu Lys Cys Glu Asn
            580                 585                 590         
Leu Gln Gln Lys Leu Glu Gln Met Asp Ala Glu Asn Lys Glu Leu Glu
        595                 600                 605             
Lys Lys Leu Ala Asn Gln Glu Glu Cys Leu Lys His Ser Asn Leu Lys
    610                 615                 620                 
Phe Lys Glu Lys Ser Ala Glu Tyr Thr Ala Leu Ala Arg Gln Leu Glu
625                 630                 635                 640 
Ala Ala Leu Glu Glu Gly Arg Gln Lys Val Ala Glu Glu Ile Glu Lys
                645                 650                 655     
Met Ser Ser Arg Glu Ser Ala Leu Gln Ile Lys Ile Leu Asp Leu Glu
            660                 665                 670         
Thr Glu Leu Arg Lys Lys Asn Glu Glu Gln Asn Gln Leu Val Cys Lys
        675                 680                 685             
Met Asn Ser Asp Pro Glu Thr Pro
    690                 695     


<210> 5628
<211> 115
<212> PRT
<213> Homo sapiens

<400> 5628
Met Gly Ser Gln Val His Leu Leu Ser Phe Leu Leu Leu Trp Ile Ser
 1               5                  10                  15      
Asp Thr Arg Ala Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser
            20                  25                  30          
Ala Thr Pro Gly Asp Lys Val Asn Ile Ser Cys Lys Ala Ser Gln Asp
        35                  40                  45              
Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala
    50                  55                  60                  
Ile Phe Ile Ile Gln Glu Ala Thr Thr Leu Val Pro Gly Ile Pro Pro
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn
                85                  90                  95      
Asn Ile Glu Ser Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln His Asp
            100                 105                 110         
Asn Phe Pro
        115 


<210> 5629
<211> 532
<212> PRT
<213> Homo sapiens

<400> 5629
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu
 1               5                  10                  15      
Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser
            20                  25                  30          
Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys
        35                  40                  45              
Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu
    50                  55                  60                  
Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu
65                  70                  75                  80  
Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys
                85                  90                  95      
Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr
            100                 105                 110         
Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly
        115                 120                 125             
Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala
    130                 135                 140                 
Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu
145                 150                 155                 160 
Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg
                165                 170                 175     
Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu
            180                 185                 190         
Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln
        195                 200                 205             
Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro
    210                 215                 220                 
Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp
225                 230                 235                 240 
Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp
                245                 250                 255     
Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala
            260                 265                 270         
Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu
        275                 280                 285             
Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr
    290                 295                 300                 
Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro
305                 310                 315                 320 
Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro
                325                 330                 335     
Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro
            340                 345                 350         
Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser
        355                 360                 365             
Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys
    370                 375                 380                 
Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu
385                 390                 395                 400 
Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr
                405                 410                 415     
Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu
            420                 425                 430         
Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr
        435                 440                 445             
Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly
    450                 455                 460                 
Glu Val Thr Arg Glu Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu
465                 470                 475                 480 
Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala
                485                 490                 495     
Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr
            500                 505                 510         
Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln
        515                 520                 525             
Ala Thr Pro Pro
    530         


<210> 5630
<211> 361
<212> PRT
<213> Homo sapiens

<400> 5630
Met Ala Gly Gly Arg His Arg Arg Val Val Gly Thr Leu His Leu Leu
 1               5                  10                  15      
Leu Leu Val Ala Ala Leu Pro Trp Ala Ser Arg Gly Val Ser Pro Ser
            20                  25                  30          
Ala Ser Ala Trp Pro Glu Glu Lys Asn Tyr His Gln Pro Ala Ile Leu
        35                  40                  45              
Asn Ser Ser Ala Leu Arg Gln Ile Ala Glu Gly Thr Ser Ile Ser Glu
    50                  55                  60                  
Met Trp Gln Asn Asp Leu Gln Pro Leu Leu Ile Glu Arg Tyr Pro Gly
65                  70                  75                  80  
Ser Pro Gly Ser Tyr Ala Ala Arg Gln His Ile Met Gln Arg Ile Gln
                85                  90                  95      
Arg Leu Gln Ala Asp Trp Val Leu Glu Ile Asp Thr Phe Leu Ser Gln
            100                 105                 110         
Thr Pro Tyr Gly Tyr Arg Ser Phe Ser Asn Ile Ile Ser Thr Leu Asn
        115                 120                 125             
Pro Thr Ala Lys Arg His Leu Val Leu Ala Cys His Tyr Asp Ser Lys
    130                 135                 140                 
Tyr Phe Ser His Trp Asn Asn Arg Val Phe Val Gly Ala Thr Asp Ser
145                 150                 155                 160 
Ala Val Pro Cys Ala Met Met Leu Glu Leu Ala Arg Ala Leu Asp Lys
                165                 170                 175     
Lys Leu Leu Ser Leu Lys Thr Val Ser Asp Ser Lys Pro Asp Leu Ser
            180                 185                 190         
Leu Gln Leu Ile Phe Phe Asp Gly Glu Glu Ala Phe Leu His Trp Ser
        195                 200                 205             
Pro Gln Asp Ser Leu Tyr Gly Ser Arg His Leu Ala Ala Lys Met Ala
    210                 215                 220                 
Ser Thr Pro His Pro Pro Gly Ala Arg Gly Thr Ser Gln Leu His Gly
225                 230                 235                 240 
Met Asp Leu Leu Val Leu Leu Asp Leu Ile Gly Ala Pro Asn Pro Thr
                245                 250                 255     
Phe Pro Asn Phe Phe Pro Asn Ser Ala Arg Trp Phe Glu Arg Leu Gln
            260                 265                 270         
Ala Ile Glu His Glu Leu His Glu Leu Gly Leu Leu Lys Asp His Ser
        275                 280                 285             
Leu Glu Gly Arg Tyr Phe Gln Asn Tyr Ser Tyr Gly Gly Val Ile Gln
    290                 295                 300                 
Asp Asp His Ile Pro Phe Leu Arg Arg Gly Val Pro Val Leu His Leu
305                 310                 315                 320 
Ile Pro Ser Pro Phe Pro Glu Val Trp His Thr Met Asp Asp Asn Glu
                325                 330                 335     
Glu Asn Leu Asp Glu Ser Thr Ile Asp Asn Leu Asn Lys Ile Leu Gln
            340                 345                 350         
Val Phe Val Leu Glu Tyr Leu His Leu
        355                 360     


<210> 5631
<211> 328
<212> PRT
<213> Homo sapiens

<400> 5631
Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr
 1               5                  10                  15      
Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu
            20                  25                  30          
Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp
        35                  40                  45              
Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg
    50                  55                  60                  
Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Glu Val Ala
65                  70                  75                  80  
Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg
                85                  90                  95      
Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn
            100                 105                 110         
Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn
        115                 120                 125             
Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro
    130                 135                 140                 
Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg
145                 150                 155                 160 
Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala
                165                 170                 175     
Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr
            180                 185                 190         
Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe
        195                 200                 205             
Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu
    210                 215                 220                 
Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly
225                 230                 235                 240 
Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr
                245                 250                 255     
Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln
            260                 265                 270         
Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg
        275                 280                 285             
Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu
    290                 295                 300                 
Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg
305                 310                 315                 320 
Lys Asn Pro Ser Lys Glu Cys Phe
                325             


<210> 5632
<211> 556
<212> PRT
<213> Homo sapiens

<400> 5632
Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr
 1               5                  10                  15      
Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu
            20                  25                  30          
Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp
        35                  40                  45              
Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg
    50                  55                  60                  
Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Glu Val Ala
65                  70                  75                  80  
Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg
                85                  90                  95      
Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn
            100                 105                 110         
Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn
        115                 120                 125             
Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro
    130                 135                 140                 
Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg
145                 150                 155                 160 
Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala
                165                 170                 175     
Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr
            180                 185                 190         
Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe
        195                 200                 205             
Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu
    210                 215                 220                 
Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly
225                 230                 235                 240 
Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr
                245                 250                 255     
Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln
            260                 265                 270         
Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg
        275                 280                 285             
Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu
    290                 295                 300                 
Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg
305                 310                 315                 320 
Lys Asn Pro Ile Asp His His Ser Ile Tyr Cys Ile Ile Ala Val Cys
                325                 330                 335     
Ser Val Phe Leu Met Leu Ile Asn Val Leu Val Ile Ile Leu Lys Met
            340                 345                 350         
Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala Lys Pro Tyr
        355                 360                 365             
Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val Val Tyr Pro
    370                 375                 380                 
Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val Glu His Phe
385                 390                 395                 400 
Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Thr
                405                 410                 415     
Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp Val Val Thr
            420                 425                 430         
Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile Phe Ile Leu
        435                 440                 445             
Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu Gln Glu Val
    450                 455                 460                 
Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val Ile Leu Ile
465                 470                 475                 480 
Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala Glu Ala Leu
                485                 490                 495     
Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr Ile Lys Trp
            500                 505                 510         
Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser Lys Phe Trp
        515                 520                 525             
Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile Pro Arg Lys
    530                 535                 540                 
Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln
545                 550                 555     


<210> 5633
<211> 259
<212> PRT
<213> Homo sapiens

<400> 5633
Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr
 1               5                  10                  15      
Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu
            20                  25                  30          
Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp
        35                  40                  45              
Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg
    50                  55                  60                  
Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Glu Val Ala
65                  70                  75                  80  
Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg
                85                  90                  95      
Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn
            100                 105                 110         
Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn
        115                 120                 125             
Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro
    130                 135                 140                 
Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg
145                 150                 155                 160 
Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala
                165                 170                 175     
Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr
            180                 185                 190         
Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Val Trp Cys Gln Ser
        195                 200                 205             
Phe Cys Lys Leu Lys Lys Ser Leu Ile Phe Ser Asn Thr His Trp Ile
    210                 215                 220                 
Gln Ser Leu Met Arg Gly Phe Val Met Val Tyr Tyr Gly Val His Lys
225                 230                 235                 240 
Cys Cys Arg Val Val Phe Asn Leu Cys Leu Gln Tyr Phe Gln His His
                245                 250                 255     
Gln Trp Pro
            


<210> 5634
<211> 271
<212> PRT
<213> Homo sapiens

<400> 5634
Asp Gly Asp Ala Thr Pro Ser Pro Pro Arg Ala Gln Pro Leu Val Pro
 1               5                  10                  15      
Val Ala His Ile Arg Pro Leu Pro Thr Thr Val Gln Ala Ala Ser Pro
            20                  25                  30          
Leu Pro Glu Glu Pro Pro Val Pro Arg Pro Pro Pro Gly Phe Gln Ala
        35                  40                  45              
Ser Val Pro Arg Glu Ala Ser Ala Arg Val Val Val Pro Ile Ala Pro
    50                  55                  60                  
Thr Cys Arg Ser Leu Glu Ser Ser Pro His Ser Leu Val Pro Met Gly
65                  70                  75                  80  
Pro Gly Arg Glu His Leu Glu Glu Pro Pro Met Ala Gly Pro Ala Ala
                85                  90                  95      
Glu Ala Glu Arg Val Ser Ser Pro Ala Trp Ala Ser Ser Pro Thr Pro
            100                 105                 110         
Pro Ser Gly Pro His Pro Cys Pro Val Pro Lys Val Ala Pro Lys Pro
        115                 120                 125             
Arg Leu Ser Gly Trp Thr Trp Leu Lys Lys Gln Leu Leu Glu Glu Ala
    130                 135                 140                 
Pro Glu Pro Pro Cys Pro Glu Pro Arg Gln Ser Leu Glu Pro Glu Val
145                 150                 155                 160 
Pro Thr Pro Thr Glu Gln Glu Val Pro Ala Pro Thr Glu Gln Glu Val
                165                 170                 175     
Pro Ala Leu Thr Ala Pro Arg Ala Pro Ala Ser Arg Thr Ser Arg Met
            180                 185                 190         
Trp Asp Ala Val Leu Tyr Arg Met Ser Val Ala Glu Ala Gln Gly Arg
        195                 200                 205             
Leu Ala Gly Pro Ser Gly Gly Glu His Thr Pro Ala Ser Leu Thr Arg
    210                 215                 220                 
Leu Pro Phe Leu Tyr Arg Pro Arg Phe Asn Ala Arg Lys Leu Gln Glu
225                 230                 235                 240 
Ala Thr Arg Pro Pro Pro Thr Val Arg Ser Ile Leu Glu Leu Ser Pro
                245                 250                 255     
Gln Pro Lys Asn Phe Asn Arg Thr Ala Thr Gly Trp Arg Leu Gln
            260                 265                 270     


<210> 5635
<211> 152
<212> PRT
<213> Homo sapiens

<400> 5635
Glu Leu Ser Ser Ser Cys Leu Ser Gly Arg Ala Pro Phe Lys Ser Ser
 1               5                  10                  15      
Asp Cys Lys Glu Arg Arg Ser Arg Cys Pro Arg Val Pro Gly Asp Cys
            20                  25                  30          
Glu Val Leu Thr Asn Cys His Trp Thr Tyr Leu Lys Gln Asn Arg Lys
        35                  40                  45              
Met Ala Ala Asn Ser Ser Gly Gln Gly Phe Gln Asn Lys Asn Arg Val
    50                  55                  60                  
Ala Ile Leu Ala Glu Leu Asp Lys Glu Lys Arg Lys Leu Leu Met Gln
65                  70                  75                  80  
Asn Gln Ser Ser Thr Asn His Pro Gly Ala Ser Ile Ala Leu Ser Arg
                85                  90                  95      
Pro Ser Leu Asn Lys Asp Phe Arg Asp His Ala Glu Gln Gln His Ile
            100                 105                 110         
Ala Ala Gln Gln Lys Ala Ala Leu Gln His Ala His Ala His Ser Ser
        115                 120                 125             
Gly Tyr Phe Ile Thr Gln Asp Ser Ala Phe Gly Asn Leu Ile Leu Pro
    130                 135                 140                 
Val Leu Pro Arg Leu Asp Pro Glu
145                 150         


<210> 5636
<211> 510
<212> PRT
<213> Homo sapiens

<400> 5636
Phe Ile Val Arg Asn Leu Cys Lys Lys Glu Thr Asn Tyr Phe Trp Leu
 1               5                  10                  15      
Pro Leu Leu His Gly His Leu Gln Glu Arg Gly Gly Ala Ala Arg Leu
            20                  25                  30          
Ser Gly Arg Lys Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala
        35                  40                  45              
Phe Gly His Ala Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val
    50                  55                  60                  
Cys Lys Glu Phe Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser
65                  70                  75                  80  
Leu Val Leu Tyr Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val
                85                  90                  95      
Ser Gln Leu Val Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala
            100                 105                 110         
Glu Gly Ala Asp Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser
        115                 120                 125             
Ala Lys Ser Cys Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr
    130                 135                 140                 
Ala Glu Cys Cys Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala
145                 150                 155                 160 
Ala Leu Lys His Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr
                165                 170                 175     
Asn Asp Glu Ile Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala
            180                 185                 190         
Asn Gln Phe Met Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu
        195                 200                 205             
Ser Leu Leu Val Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser
    210                 215                 220                 
Cys Cys Thr Ser Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu
225                 230                 235                 240 
Gln Leu Lys His Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys
                245                 250                 255     
Ser Gln Tyr Ala Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu
            260                 265                 270         
Ile Lys Leu Ala Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu
        275                 280                 285             
Pro Leu Ala Glu Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser
    290                 295                 300                 
Ala Ser Glu Asp Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys
305                 310                 315                 320 
Leu Cys Asp Asn Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys
                325                 330                 335     
Gln Glu Lys Thr Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro
            340                 345                 350         
Ala Ala Gln Leu Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys
        355                 360                 365             
Asp Val Cys Asp Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe
    370                 375                 380                 
Glu Leu Ser Arg Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val
385                 390                 395                 400 
Leu Glu Pro Thr Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp
                405                 410                 415     
Ser Thr Thr Cys Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu
            420                 425                 430         
Ser Ser Phe Ile Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu
        435                 440                 445             
Asn Thr Phe Thr Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala
    450                 455                 460                 
Lys Leu Pro Asp Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys
465                 470                 475                 480 
His Ser Asp Phe Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu
                485                 490                 495     
Tyr Cys Asp Ser Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu
            500                 505                 510 


<210> 5637
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 5637
Met Ala Ala Gly Cys Leu Leu Ala Leu Thr Leu Thr Leu Phe Gln Ser
 1               5                  10                  15      
Leu Leu Ile Gly Pro Ser Ser Glu Glu Pro Phe Pro Ser Ala Val Thr
            20                  25                  30          
Ile Lys Ser Trp Val Asp Lys Met Gln Glu Asp Leu Val Thr Leu Ala
        35                  40                  45              
Lys Thr Ala Ser Gly Val Asn Gln Leu Val Asp Ile Tyr Glu Lys Tyr
    50                  55                  60                  
Gln Asp Leu Tyr Thr Val Glu Pro Asn Asn Ala Arg Gln Leu Val Glu
65                  70                  75                  80  
Ile Ala Ala Arg Asp Ile Glu Lys Leu Leu Ser Asn Arg Ser Lys Ala
                85                  90                  95      
Leu Val Ser Leu Ala Leu Glu Ala Glu Lys Val Gln Ala Ala His Gln
            100                 105                 110         
Trp Arg Glu Asp Phe Ala Ser Asn Glu Val Val Tyr Tyr Asn Ala Lys
        115                 120                 125             
Asp Asp Leu Asp Pro Glu Lys Asn Asp Ser Glu Pro Gly Ser Gln Arg
    130                 135                 140                 
Ile Lys Pro Val Phe Ile Glu Asp Ala Asn Phe Gly Arg Gln Ile Ser
145                 150                 155                 160 
Tyr Gln His Ala Ala Val His Ile Pro Thr Asp Ile Tyr Glu Gly Ser
                165                 170                 175     
Thr Ile Val Leu Asn Glu Leu Asn Trp Thr Ser Ala Leu Asp Glu Val
            180                 185                 190         
Phe Lys Lys Asn Arg Glu Glu Asp Pro Ser Leu Leu Trp Gln Val Phe
        195                 200                 205             
Gly Ser Ala Thr Gly Leu Ala Arg Tyr Tyr Pro Ala Ser Pro Trp Val
    210                 215                 220                 
Asp Asn Ser Arg Thr Pro Asn Lys Ile Asp Leu Tyr Asp Val Arg Arg
225                 230                 235                 240 
Arg Pro Trp Tyr Ile Gln Gly Ala Ala Ser Pro Lys Asp Met Leu Ile
                245                 250                 255     
Leu Val Asp Val Ser Gly Ser Val Ser Gly Leu Thr Leu Lys Leu Ile
            260                 265                 270         
Arg Thr Ser Val Ser Glu Met Leu Glu Thr Leu Ser Asp Asp Asp Phe
        275                 280                 285             
Val Asn Val Ala Ser Phe Asn Ser Asn Ala Gln Asp Val Ser Cys Phe
    290                 295                 300                 
Gln His Leu Val Gln Ala Asn Val Arg Asn Lys Lys Val Leu Lys Asp
305                 310                 315                 320 
Ala Val Asn Asn Ile Thr Ala Lys Gly Ile Thr Asp Tyr Lys Lys Gly
                325                 330                 335     
Phe Ser Phe Ala Phe Glu Gln Leu Leu Asn Tyr Asn Val Ser Arg Ala
            340                 345                 350         
Asn Cys Asn Lys Ile Ile Met Leu Phe Thr Asp Gly Gly Glu Glu Arg
        355                 360                 365             
Ala Gln Glu Ile Phe Asn Lys Tyr Asn Lys Asp Lys Lys Val Arg Val
    370                 375                 380                 
Phe Arg Phe Ser Val Gly Gln His Asn Tyr Glu Arg Gly Pro Ile Gln
385                 390                 395                 400 
Trp Met Ala Cys Glu Asn Lys Gly Tyr Tyr Tyr Glu Ile Pro Ser Ile
                405                 410                 415     
Gly Ala Ile Arg Ile Asn Thr Gln Glu Tyr Leu Asp Val Leu Gly Arg
            420                 425                 430         
Pro Met Val Leu Ala Gly Asp Lys Ala Lys Gln Val Gln Trp Thr Asn
        435                 440                 445             
Val Tyr Leu Asp Ala Leu Glu Leu Gly Leu Val Ile Thr Gly Thr Leu
    450                 455                 460                 
Pro Val Phe Asn Ile Thr Gly Gln Phe Glu Asn Lys Thr Asn Leu Lys
465                 470                 475                 480 
Asn Gln Leu Ile Leu Gly Val Met Gly Val Asp Val Ser Leu Glu Asp
                485                 490                 495     
Ile Lys Arg Leu Thr Pro Arg Phe Thr Leu Cys Pro Asn Gly Tyr Tyr
            500                 505                 510         
Phe Ala Ile Asp Pro Asn Gly Tyr Val Leu Leu His Pro Asn Leu Gln
        515                 520                 525             
Pro Lys Asn Pro Lys Ser Gln Glu Pro Val Thr Leu Asp Phe Leu Asp
    530                 535                 540                 
Ala Glu Leu Glu Asn Asp Ile Lys Val Glu Ile Arg Asn Lys Met Ile
545                 550                 555                 560 
Asp Gly Glu Ser Gly Glu Lys Thr Phe Arg Thr Leu Val Lys Ser Gln
                565                 570                 575     
Asp Glu Arg Tyr Ile Asp Lys Gly Asn Arg Thr Tyr Thr Trp Thr Pro
            580                 585                 590         
Val Asn Gly Thr Asp Tyr Ser Leu Ala Leu Val Leu Pro Thr Tyr Ser
        595                 600                 605             
Phe Tyr Tyr Ile Lys Ala Lys Leu Glu Glu Thr Ile Thr Gln Ala Arg
    610                 615                 620                 
Ser Lys Lys Gly Lys Met Lys Asp Ser Glu Thr Leu Lys Pro Asp Asn
625                 630                 635                 640 
Phe Glu Glu Ser Gly Tyr Thr Phe Ile Ala Pro Arg Asp Tyr Cys Asn
                645                 650                 655     
Asp Leu Lys Ile Ser Asp Asn Asn Thr Glu Phe Leu Leu Asn Phe Asn
            660                 665                 670         
Glu Phe Ile Asp Arg Lys Thr Pro Asn Asn Pro Ser Cys Asn Ala Asp
        675                 680                 685             
Leu Ile Asn Arg Val Leu Leu Asp Ala Gly Phe Thr Asn Glu Leu Val
    690                 695                 700                 
Gln Asn Tyr Trp Ser Lys Gln Lys Asn Ile Lys Gly Val Lys Ala Arg
705                 710                 715                 720 
Phe Val Val Thr Asp Gly Gly Ile Thr Arg Val Tyr Pro Lys Glu Ala
                725                 730                 735     
Gly Glu Asn Trp Gln Glu Asn Pro Glu Thr Tyr Glu Asp Ser Phe Tyr
            740                 745                 750         
Lys Arg Ser Leu Asp Asn Asp Asn Tyr Val Phe Thr Ala Pro Tyr Phe
        755                 760                 765             
Asn Lys Ser Gly Pro Gly Ala Tyr Glu Ser Gly Ile Met Val Ser Lys
    770                 775                 780                 
Ala Val Glu Ile Tyr Ile Gln Gly Lys Leu Leu Lys Pro Ala Val Val
785                 790                 795                 800 
Gly Ile Lys Ile Asp Val Asn Ser Trp Ile Glu Asn Phe Thr Lys Thr
                805                 810                 815     
Ser Ile Arg Asp Pro Cys Ala Gly Pro Val Cys Asp Cys Lys Arg Asn
            820                 825                 830         
Ser Asp Val Met Asp Cys Val Ile Leu Asp Asp Gly Gly Phe Leu Leu
        835                 840                 845             
Met Ala Asn His Asp Asp Tyr Thr Asn Gln Ile Gly Arg Phe Phe Gly
    850                 855                 860                 
Glu Ile Asp Pro Ser Leu Met Arg His Leu Val Asn Ile Ser Val Tyr
865                 870                 875                 880 
Ala Phe Asn Lys Ser Tyr Asp Tyr Gln Ser Val Cys Glu Pro Gly Ala
                885                 890                 895     
Ala Pro Lys Gln Gly Ala Gly His Arg Ser Ala Tyr Val Pro Ser Val
            900                 905                 910         
Ala Asp Ile Leu Gln Ile Gly Trp Trp Ala Thr Ala Ala Ala Trp Ser
        915                 920                 925             
Ile Leu Gln Gln Phe Leu Leu Ser Leu Thr Phe Pro Arg Leu Leu Glu
    930                 935                 940                 
Ala Val Glu Met Glu Asp Asp Asp Phe Thr Ala Ser Leu Ser Lys Gln
945                 950                 955                 960 
Ser Cys Ile Thr Glu Gln Thr Gln Tyr Phe Phe Asp Asn Asp Ser Lys
                965                 970                 975     
Ser Phe Ser Gly Val Leu Asp Cys Gly Asn Cys Ser Arg Ile Phe His
            980                 985                 990         
Gly Glu Lys Leu Met Asn Thr Asn Leu Ile Phe Ile Met Val Glu Ser
        995                 1000                1005            
Lys Gly Thr Cys Pro Cys Asp Thr Arg Leu Leu Ile Gln Ala Glu Gln
    1010                1015                1020                
Thr Ser Asp Gly Pro Asn Pro Cys Asp Met Val Lys Gln Pro Arg Tyr
1025                1030                1035                1040
Arg Lys Gly Pro Asp Val Cys Phe Asp Asn Asn Val Leu Glu Asp Tyr
                1045                1050                1055    
Thr Asp Cys Gly Gly Val Ser Gly Leu Asn Pro Ser Leu Trp Tyr Ile
            1060                1065                1070        
Ile Gly Ile Gln Phe Leu Leu Leu Trp Leu Val Ser Gly Ser Thr His
        1075                1080                1085            
Arg Leu Leu
    1090    


<210> 5638
<211> 918
<212> PRT
<213> Homo sapiens

<400> 5638
Met Leu Thr Leu Gln Thr Trp Val Val Gln Ala Leu Phe Ile Phe Leu
 1               5                  10                  15      
Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser
            20                  25                  30          
Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys
        35                  40                  45              
Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr
    50                  55                  60                  
Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr
65                  70                  75                  80  
Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser
                85                  90                  95      
Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu
            100                 105                 110         
Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys
        115                 120                 125             
Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys
    130                 135                 140                 
Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu
145                 150                 155                 160 
Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg
                165                 170                 175     
Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val
            180                 185                 190         
Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr
        195                 200                 205             
Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro
    210                 215                 220                 
Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu
225                 230                 235                 240 
Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys
                245                 250                 255     
Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile
            260                 265                 270         
Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp
        275                 280                 285             
Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu
    290                 295                 300                 
Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile
305                 310                 315                 320 
Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile
                325                 330                 335     
Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys
            340                 345                 350         
Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val
        355                 360                 365             
Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala
    370                 375                 380                 
Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu
385                 390                 395                 400 
Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile
                405                 410                 415     
Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala
            420                 425                 430         
Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu
        435                 440                 445             
Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala
    450                 455                 460                 
Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr
465                 470                 475                 480 
Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val
                485                 490                 495     
Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala
            500                 505                 510         
Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys
        515                 520                 525             
Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val
    530                 535                 540                 
Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr
545                 550                 555                 560 
Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu
                565                 570                 575     
Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met
            580                 585                 590         
Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe
        595                 600                 605             
Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro
    610                 615                 620                 
Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys
625                 630                 635                 640 
Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro
                645                 650                 655     
Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro
            660                 665                 670         
Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe
        675                 680                 685             
Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe
    690                 695                 700                 
Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn
705                 710                 715                 720 
Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser
                725                 730                 735     
Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn
            740                 745                 750         
Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg
        755                 760                 765             
His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln
    770                 775                 780                 
Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp
785                 790                 795                 800 
His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys
                805                 810                 815     
Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu
            820                 825                 830         
Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu
        835                 840                 845             
Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln
    850                 855                 860                 
Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly
865                 870                 875                 880 
Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala
                885                 890                 895     
Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln
            900                 905                 910         
Gly Gly Tyr Met Pro Gln
        915             


<210> 5639
<211> 329
<212> PRT
<213> Homo sapiens

<400> 5639
Met Leu Thr Leu Gln Thr Trp Val Val Gln Ala Leu Phe Ile Phe Leu
 1               5                  10                  15      
Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser
            20                  25                  30          
Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys
        35                  40                  45              
Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr
    50                  55                  60                  
Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr
65                  70                  75                  80  
Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser
                85                  90                  95      
Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu
            100                 105                 110         
Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys
        115                 120                 125             
Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys
    130                 135                 140                 
Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu
145                 150                 155                 160 
Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg
                165                 170                 175     
Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val
            180                 185                 190         
Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr
        195                 200                 205             
Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro
    210                 215                 220                 
Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu
225                 230                 235                 240 
Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys
                245                 250                 255     
Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile
            260                 265                 270         
Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp
        275                 280                 285             
Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu
    290                 295                 300                 
Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile
305                 310                 315                 320 
Thr Tyr Glu Asp Asn Ile Ala Ser Phe
                325                 


<210> 5640
<211> 117
<212> PRT
<213> Homo sapiens

<400> 5640
Met Glu Phe Gly Leu Asn Trp Val Phe Leu Val Ala Ile Ile Lys Gly
 1               5                  10                  15      
Ala Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Asn His Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn
                85                  90                  95      
Ser Pro Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Val Lys
        115         


<210> 5641
<211> 123
<212> PRT
<213> Homo sapiens

<400> 5641
Ile Gly Trp Thr Cys Lys Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
 1               5                  10                  15      
Ala Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Asn His Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn
                85                  90                  95      
Ser Pro Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Val Lys His Thr Ala Arg Gly Ser
        115                 120             


<210> 5642
<211> 117
<212> PRT
<213> Homo sapiens

<400> 5642
Met Glu Phe Gly Leu Asn Trp Val Phe Leu Val Ala Ile Ile Lys Gly
 1               5                  10                  15      
Ala Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Pro Asp Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Asn His Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn
                85                  90                  95      
Ser Pro Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Val Lys
        115         


<210> 5643
<211> 123
<212> PRT
<213> Homo sapiens

<400> 5643
Ile Gly Trp Thr Cys Lys Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
 1               5                  10                  15      
Ala Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Pro Asp Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Asn His Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Ile Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn
                85                  90                  95      
Ser Pro Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Val Lys His Thr Ala Arg Gly Ser
        115                 120             


<210> 5644
<211> 112
<212> PRT
<213> Homo sapiens

<400> 5644
Trp Thr Cys Lys Ile Leu Phe Leu Val Ala Ala Ala Thr Gly Ala His
 1               5                  10                  15      
Phe Leu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
            20                  25                  30          
Ala Ser Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Thr Phe Thr Tyr
        35                  40                  45              
Cys Tyr Leu His Trp Val Arg Trp Ala Pro Gly Gln Gly Leu Glu Trp
    50                  55                  60                  
Thr Gly Phe Tyr Gly Asp Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val
65                  70                  75                  80  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Pro Tyr
                85                  90                  95      
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
            100                 105                 110         


<210> 5645
<211> 448
<212> PRT
<213> Homo sapiens

<400> 5645
Met Asp Pro Lys Tyr Phe Ile Leu Ile Leu Phe Cys Gly His Leu Asn
 1               5                  10                  15      
Asn Thr Phe Phe Ser Lys Thr Glu Thr Ile Thr Thr Glu Lys Gln Ser
            20                  25                  30          
Gln Pro Thr Leu Tyr Thr Ser Ser Met Ser Gln Val Leu Ala Asn Ser
        35                  40                  45              
Gln Asn Thr Thr Gly Asn Pro Leu Gly Gln Pro Thr Gln Phe Ser Asp
    50                  55                  60                  
Thr Phe Ser Gly Gln Ser Ile Ser Pro Ala Lys Val Thr Ala Gly Gln
65                  70                  75                  80  
Pro Thr Pro Ala Val Tyr Thr Ser Ser Glu Lys Pro Glu Ala His Thr
                85                  90                  95      
Ser Ala Gly Gln Pro Leu Ala Tyr Asn Thr Lys Gln Pro Thr Pro Ile
            100                 105                 110         
Ala Asn Thr Ser Ser Gln Gln Ala Val Phe Thr Ser Ala Arg Gln Leu
        115                 120                 125             
Pro Ser Ala Arg Thr Ser Thr Thr Gln Pro Pro Lys Ser Phe Val Tyr
    130                 135                 140                 
Thr Phe Thr Gln Gln Ser Ser Ser Val Gln Ile Pro Ser Arg Lys Gln
145                 150                 155                 160 
Ile Thr Val His Asn Pro Ser Thr Gln Pro Thr Ser Thr Val Lys Asn
                165                 170                 175     
Ser Pro Arg Ser Thr Pro Gly Phe Ile Leu Asp Thr Thr Ser Asn Lys
            180                 185                 190         
Gln Thr Pro Gln Lys Asn Asn Tyr Asn Ser Ile Ala Ala Ile Leu Ile
        195                 200                 205             
Gly Val Leu Leu Thr Ser Met Leu Val Ala Ile Ile Ile Ile Val Leu
    210                 215                 220                 
Trp Lys Cys Leu Arg Lys Pro Val Leu Asn Asp Gln Asn Trp Ala Gly
225                 230                 235                 240 
Arg Ser Pro Phe Ala Asp Gly Glu Thr Pro Asp Ile Cys Met Asp Asn
                245                 250                 255     
Ile Arg Glu Asn Glu Ile Ser Thr Lys Arg Thr Ser Ile Ile Ser Leu
            260                 265                 270         
Thr Pro Trp Lys Pro Ser Lys Ser Thr Leu Leu Ala Asp Asp Leu Glu
        275                 280                 285             
Ile Lys Leu Phe Glu Ser Ser Glu Asn Ile Glu Asp Ser Asn Asn Pro
    290                 295                 300                 
Lys Thr Glu Lys Ile Lys Asp Gln Val Asn Gly Thr Ser Glu Asp Ser
305                 310                 315                 320 
Ala Asp Gly Ser Thr Val Gly Thr Ala Val Ser Ser Ser Asp Asp Ala
                325                 330                 335     
Asp Leu Pro Pro Pro Pro Pro Leu Leu Asp Leu Glu Gly Gln Glu Ser
            340                 345                 350         
Asn Gln Ser Asp Lys Pro Thr Met Thr Ile Val Ser Pro Leu Pro Asn
        355                 360                 365             
Asp Ser Thr Ser Leu Pro Pro Ser Leu Asp Cys Leu Asn Gln Asp Cys
    370                 375                 380                 
Gly Asp His Lys Ser Glu Ile Ile Gln Ser Phe Pro Pro Leu Asp Ser
385                 390                 395                 400 
Leu Asn Leu Pro Leu Pro Pro Val Asp Phe Met Lys Asn Gln Glu Asp
                405                 410                 415     
Ser Asn Leu Glu Ile Gln Cys Gln Glu Phe Ser Ile Pro Pro Asn Ser
            420                 425                 430         
Asp Gln Asp Leu Asn Glu Ser Leu Pro Pro Pro Pro Ala Glu Leu Leu
        435                 440                 445             


<210> 5646
<211> 401
<212> PRT
<213> Homo sapiens

<400> 5646
Met Trp Ser Gly Gly Ser Gly Lys Ala Arg Gly Trp Glu Ala Ala Ala
 1               5                  10                  15      
Gly Gly Arg Ser Ser Pro Gly Arg Leu Ser Arg Arg Arg Ile Met Ser
            20                  25                  30          
Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile Leu Ser
        35                  40                  45              
Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly Gly Leu
    50                  55                  60                  
Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro Pro Thr
65                  70                  75                  80  
Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val Thr Ala
                85                  90                  95      
Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His Ser Ala
            100                 105                 110         
Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu Leu Pro
        115                 120                 125             
Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly Trp Tyr
    130                 135                 140                 
Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe Met Gly
145                 150                 155                 160 
Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly Ser Leu
                165                 170                 175     
Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro Arg Arg
            180                 185                 190         
Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg
        195                 200                 205             
Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu His Leu
    210                 215                 220                 
Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp Phe Gln
225                 230                 235                 240 
Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala Ala Gln
                245                 250                 255     
Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly Gly Thr
            260                 265                 270         
Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro Arg Arg Val
        275                 280                 285             
Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln Ala Gly Ala
    290                 295                 300                 
Pro Ala Pro Gly Ala Ala Ser Leu Gln Gly His Ala Gln Gln Gln Ala
305                 310                 315                 320 
Gln His Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala Ile Ser Val
                325                 330                 335     
Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His Gln Pro Gly
            340                 345                 350         
Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala Ser Pro Ala
        355                 360                 365             
Ala Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn Ser Ser Gly
    370                 375                 380                 
Ser Asp Tyr Gly Thr Met Ser Cys Ser Thr Leu Leu Tyr Gly Arg Thr
385                 390                 395                 400 
Trp
    


<210> 5647
<211> 371
<212> PRT
<213> Homo sapiens

<400> 5647
Met Ser Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile
 1               5                  10                  15      
Leu Ser Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly
            20                  25                  30          
Gly Leu Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro
        35                  40                  45              
Pro Thr Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val
    50                  55                  60                  
Thr Ala Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His
65                  70                  75                  80  
Ser Ala Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu
                85                  90                  95      
Leu Pro Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly
            100                 105                 110         
Trp Tyr Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe
        115                 120                 125             
Met Gly Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly
    130                 135                 140                 
Ser Leu Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro
145                 150                 155                 160 
Arg Arg Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu
                165                 170                 175     
Glu Arg Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu
            180                 185                 190         
His Leu Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp
        195                 200                 205             
Phe Gln Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala
    210                 215                 220                 
Ala Gln Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly
225                 230                 235                 240 
Gly Thr Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro Arg
                245                 250                 255     
Arg Val Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln Ala
            260                 265                 270         
Gly Ala Pro Ala Pro Gly Ala Ala Ser Leu Gln Gly His Ala Gln Gln
        275                 280                 285             
Gln Ala Gln His Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala Ile
    290                 295                 300                 
Ser Val Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His Gln
305                 310                 315                 320 
Pro Gly Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala Ser
                325                 330                 335     
Pro Ala Ala Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn Ser
            340                 345                 350         
Ser Gly Ser Asp Tyr Gly Thr Met Ser Cys Ser Thr Leu Leu Tyr Gly
        355                 360                 365             
Arg Thr Trp
    370     


<210> 5648
<211> 1841
<212> PRT
<213> Homo sapiens

<400> 5648
Arg Gly Ala Met Ala Leu Gln Leu Trp Ala Leu Thr Leu Leu Gly Leu
 1               5                  10                  15      
Leu Gly Ala Gly Ala Ser Leu Arg Pro Arg Lys Leu Asp Phe Phe Arg
            20                  25                  30          
Ser Glu Lys Glu Leu Asn His Leu Ala Val Asp Glu Ala Ser Gly Val
        35                  40                  45              
Val Tyr Leu Gly Ala Val Asn Ala Leu Tyr Gln Leu Asp Ala Lys Leu
    50                  55                  60                  
Gln Leu Glu Gln Gln Val Ala Thr Gly Pro Ala Leu Asp Asn Lys Lys
65                  70                  75                  80  
Cys Thr Pro Pro Ile Glu Ala Ser Gln Cys His Glu Ala Glu Met Thr
                85                  90                  95      
Asp Asn Val Asn Gln Leu Leu Leu Leu Asp Pro Pro Arg Lys Arg Leu
            100                 105                 110         
Val Glu Cys Gly Ser Leu Phe Lys Gly Ile Cys Ala Leu Arg Ala Leu
        115                 120                 125             
Ser Asn Ile Ser Leu Arg Leu Phe Tyr Glu Asp Gly Ser Gly Glu Lys
    130                 135                 140                 
Ser Phe Val Ala Ser Asn Asp Glu Gly Val Ala Thr Val Gly Leu Val
145                 150                 155                 160 
Ser Ser Thr Gly Pro Gly Gly Asp Arg Val Leu Phe Val Gly Lys Gly
                165                 170                 175     
Asn Gly Pro His Asp Asn Gly Ile Ile Val Ser Thr Arg Leu Leu Asp
            180                 185                 190         
Arg Thr Asp Ser Arg Glu Ala Phe Glu Ala Tyr Thr Asp His Ala Thr
        195                 200                 205             
Tyr Lys Ala Gly Tyr Leu Ser Thr Asn Thr Gln Gln Phe Val Ala Ala
    210                 215                 220                 
Phe Glu Asp Gly Pro Tyr Val Phe Phe Val Phe Asn Gln Gln Asp Lys
225                 230                 235                 240 
His Pro Ala Arg Asn Arg Thr Leu Leu Ala Arg Met Cys Arg Glu Asp
                245                 250                 255     
Pro Asn Tyr Tyr Ser Tyr Leu Glu Met Asp Leu Gln Cys Arg Asp Pro
            260                 265                 270         
Asp Ile His Ala Ala Ala Phe Gly Thr Cys Leu Ala Ala Ser Val Ala
        275                 280                 285             
Ala Pro Gly Ser Gly Arg Val Leu Tyr Ala Val Phe Ser Arg Asp Ser
    290                 295                 300                 
Arg Ser Ser Gly Gly Pro Gly Ala Gly Leu Cys Leu Phe Pro Leu Asp
305                 310                 315                 320 
Lys Val His Ala Lys Met Glu Ala Asn Arg Asn Ala Cys Tyr Thr Gly
                325                 330                 335     
Thr Arg Glu Ala Arg Asp Ile Phe Tyr Lys Pro Phe His Gly Asp Ile
            340                 345                 350         
Gln Cys Gly Gly His Ala Pro Gly Ser Ser Lys Ser Phe Pro Cys Gly
        355                 360                 365             
Ser Glu His Leu Pro Tyr Pro Leu Gly Ser Arg Asp Gly Leu Arg Gly
    370                 375                 380                 
Thr Ala Val Leu Gln Arg Gly Gly Leu Asn Leu Thr Ala Val Thr Val
385                 390                 395                 400 
Ala Ala Glu Asn Asn His Thr Val Ala Phe Leu Gly Thr Ser Asp Gly
                405                 410                 415     
Arg Ile Leu Lys Val Tyr Leu Thr Pro Asp Gly Thr Ser Ser Glu Tyr
            420                 425                 430         
Asp Ser Ile Leu Val Glu Ile Asn Lys Arg Val Lys Arg Asp Leu Val
        435                 440                 445             
Leu Ser Gly Asp Leu Gly Ser Leu Tyr Ala Met Thr Gln Asp Lys Val
    450                 455                 460                 
Phe Arg Leu Pro Val Gln Glu Cys Leu Ser Tyr Pro Thr Cys Thr Gln
465                 470                 475                 480 
Cys Arg Asp Ser Gln Asp Pro Tyr Cys Gly Trp Cys Val Val Glu Gly
                485                 490                 495     
Arg Cys Thr Arg Lys Ala Glu Cys Pro Arg Ala Glu Glu Ala Ser His
            500                 505                 510         
Trp Leu Trp Ser Arg Ser Lys Ser Cys Val Ala Val Thr Ser Ala Gln
        515                 520                 525             
Pro Gln Asn Met Ser Arg Arg Ala Gln Gly Glu Val Gln Leu Thr Val
    530                 535                 540                 
Ser Pro Leu Pro Ala Leu Ser Glu Glu Asp Glu Leu Leu Cys Leu Phe
545                 550                 555                 560 
Gly Glu Ser Pro Pro His Pro Ala Arg Val Glu Gly Glu Ala Val Ile
                565                 570                 575     
Cys Asn Ser Pro Ser Ser Ile Pro Val Thr Pro Pro Gly Gln Asp His
            580                 585                 590         
Val Ala Val Thr Ile Gln Leu Leu Leu Arg Arg Gly Asn Ile Phe Leu
        595                 600                 605             
Thr Ser Tyr Gln Tyr Pro Phe Tyr Asp Cys Arg Gln Ala Met Ser Leu
    610                 615                 620                 
Glu Glu Asn Leu Pro Cys Ile Ser Cys Val Ser Asn Arg Trp Thr Cys
625                 630                 635                 640 
Gln Trp Asp Leu Arg Tyr His Glu Cys Arg Glu Ala Ser Pro Asn Pro
                645                 650                 655     
Glu Asp Gly Ile Val Arg Ala His Met Glu Asp Ser Cys Pro Gln Phe
            660                 665                 670         
Leu Gly Pro Ser Pro Leu Val Ile Pro Met Asn His Glu Thr Asp Val
        675                 680                 685             
Asn Phe Gln Gly Lys Asn Leu Asp Thr Val Lys Gly Ser Ser Leu His
    690                 695                 700                 
Val Gly Ser Asp Leu Leu Lys Phe Met Glu Pro Val Thr Met Gln Glu
705                 710                 715                 720 
Ser Gly Thr Phe Ala Phe Arg Thr Pro Lys Leu Ser His Asp Ala Asn
                725                 730                 735     
Glu Thr Leu Pro Leu His Leu Tyr Val Lys Ser Tyr Gly Lys Asn Ile
            740                 745                 750         
Asp Ser Lys Leu His Val Thr Leu Tyr Asn Cys Ser Phe Gly Arg Ser
        755                 760                 765             
Asp Cys Ser Leu Cys Arg Ala Ala Asn Pro Asp Tyr Arg Cys Ala Trp
    770                 775                 780                 
Cys Gly Gly Gln Ser Arg Cys Val Tyr Glu Ala Leu Cys Asn Thr Thr
785                 790                 795                 800 
Ser Glu Cys Pro Pro Pro Val Ile Thr Arg Ile Gln Pro Glu Thr Gly
                805                 810                 815     
Pro Leu Gly Gly Gly Ile Arg Ile Thr Ile Leu Gly Ser Asn Leu Gly
            820                 825                 830         
Val Gln Ala Gly Asp Ile Gln Arg Ile Ser Val Ala Gly Arg Asn Cys
        835                 840                 845             
Ser Phe Gln Pro Glu Arg Tyr Ser Val Ser Thr Arg Ile Val Cys Val
    850                 855                 860                 
Ile Glu Ala Ala Glu Thr Pro Phe Thr Gly Gly Val Glu Val Asp Val
865                 870                 875                 880 
Phe Gly Lys Leu Gly Arg Ser Pro Pro Asn Val Gln Phe Thr Phe Gln
                885                 890                 895     
Gln Pro Lys Pro Leu Ser Val Glu Pro Gln Gln Gly Pro Gln Ala Gly
            900                 905                 910         
Gly Thr Thr Leu Thr Ile His Gly Thr His Leu Asp Thr Gly Ser Gln
        915                 920                 925             
Glu Asp Val Arg Val Thr Leu Asn Gly Val Pro Cys Lys Val Thr Lys
    930                 935                 940                 
Phe Gly Ala Gln Leu Gln Cys Val Thr Gly Pro Gln Ala Thr Arg Gly
945                 950                 955                 960 
Gln Met Leu Leu Glu Val Ser Tyr Gly Gly Ser Pro Val Pro Asn Pro
                965                 970                 975     
Gly Ile Phe Phe Thr Tyr Arg Glu Asn Pro Val Leu Arg Ala Phe Glu
            980                 985                 990         
Pro Leu Arg Ser Phe Ala Ser Gly Gly Arg Ser Ile Asn Val Thr Gly
        995                 1000                1005            
Gln Gly Phe Ser Leu Ile Gln Arg Phe Ala Met Val Val Ile Ala Glu
    1010                1015                1020                
Pro Leu Gln Ser Trp Gln Pro Pro Arg Glu Ala Glu Ser Leu Gln Pro
1025                1030                1035                1040
Met Thr Val Val Gly Thr Asp Tyr Val Phe His Asn Asp Thr Lys Val
                1045                1050                1055    
Val Phe Leu Ser Pro Ala Val Pro Glu Glu Pro Glu Ala Tyr Asn Leu
            1060                1065                1070        
Thr Val Leu Ile Glu Met Asp Gly His Arg Ala Leu Leu Arg Thr Glu
        1075                1080                1085            
Ala Gly Ala Phe Glu Tyr Val Pro Asp Pro Thr Phe Glu Asn Phe Thr
    1090                1095                1100                
Gly Gly Val Lys Lys Gln Val Asn Lys Leu Ile His Ala Arg Gly Thr
1105                1110                1115                1120
Asn Leu Asn Lys Ala Met Thr Leu Gln Glu Ala Glu Ala Phe Val Gly
                1125                1130                1135    
Ala Glu Arg Cys Thr Met Lys Thr Leu Thr Glu Thr Asp Leu Tyr Cys
            1140                1145                1150        
Glu Pro Pro Glu Val Gln Pro Pro Pro Lys Arg Arg Gln Lys Arg Asp
        1155                1160                1165            
Thr Thr His Asn Leu Pro Glu Phe Ile Val Lys Phe Gly Ser Arg Glu
    1170                1175                1180                
Trp Val Leu Gly Arg Val Glu Tyr Asp Thr Arg Val Ser Asp Val Pro
1185                1190                1195                1200
Leu Ser Leu Ile Leu Pro Leu Val Ile Val Pro Met Val Val Val Ile
                1205                1210                1215    
Ala Val Ser Val Tyr Cys Tyr Trp Arg Lys Ser Gln Gln Ala Glu Arg
            1220                1225                1230        
Glu Tyr Glu Lys Ile Lys Ser Gln Leu Glu Gly Leu Glu Glu Ser Val
        1235                1240                1245            
Arg Asp Arg Cys Lys Lys Glu Phe Thr Asp Leu Met Ile Glu Met Glu
    1250                1255                1260                
Asp Gln Thr Asn Asp Val His Glu Ala Gly Ile Pro Val Leu Asp Tyr
1265                1270                1275                1280
Lys Thr Tyr Thr Asp Arg Val Phe Phe Leu Pro Ser Lys Asp Gly Asp
                1285                1290                1295    
Lys Asp Val Met Ile Thr Gly Lys Leu Asp Ile Pro Glu Pro Arg Arg
            1300                1305                1310        
Pro Val Val Glu Gln Ala Leu Tyr Gln Phe Ser Asn Leu Leu Asn Ser
        1315                1320                1325            
Lys Ser Phe Leu Ile Asn Phe Ile His Thr Leu Glu Asn Gln Arg Glu
    1330                1335                1340                
Phe Ser Ala Arg Ala Lys Val Tyr Phe Ala Ser Leu Leu Thr Val Ala
1345                1350                1355                1360
Leu His Gly Lys Leu Glu Tyr Tyr Thr Asp Ile Met His Thr Leu Phe
                1365                1370                1375    
Leu Glu Leu Leu Glu Gln Tyr Val Val Ala Lys Asn Pro Lys Leu Met
            1380                1385                1390        
Leu Arg Arg Ser Glu Thr Val Val Glu Arg Met Leu Ser Asn Trp Met
        1395                1400                1405            
Ser Ile Cys Leu Tyr Gln Tyr Leu Lys Asp Ser Ala Gly Glu Pro Leu
    1410                1415                1420                
Tyr Lys Leu Phe Lys Ala Ile Lys His Gln Val Glu Lys Gly Pro Val
1425                1430                1435                1440
Asp Ala Val Gln Lys Lys Ala Lys Tyr Thr Leu Asn Asp Thr Gly Leu
                1445                1450                1455    
Leu Gly Asp Asp Val Glu Tyr Ala Pro Leu Thr Val Ser Val Ile Val
            1460                1465                1470        
Gln Asp Glu Gly Val Asp Ala Ile Pro Val Lys Val Leu Asn Cys Asp
        1475                1480                1485            
Thr Ile Ser Gln Val Lys Glu Lys Ile Ile Asp Gln Val Tyr Arg Gly
    1490                1495                1500                
Gln Pro Cys Ser Cys Trp Pro Arg Pro Asp Ser Val Val Leu Glu Trp
1505                1510                1515                1520
Arg Pro Gly Ser Thr Ala Gln Ile Leu Ser Asp Leu Asp Leu Thr Ser
                1525                1530                1535    
Gln Arg Glu Gly Arg Trp Lys Arg Val Asn Thr Leu Met His Tyr Asn
            1540                1545                1550        
Val Arg Asp Gly Ala Thr Leu Ile Leu Ser Lys Val Gly Val Ser Gln
        1555                1560                1565            
Gln Pro Glu Asp Ser Gln Gln Asp Leu Pro Gly Glu Arg His Ala Leu
    1570                1575                1580                
Leu Glu Glu Glu Asn Arg Val Trp His Leu Val Arg Pro Thr Asp Glu
1585                1590                1595                1600
Val Asp Glu Gly Lys Ser Lys Arg Gly Ser Val Lys Glu Lys Glu Arg
                1605                1610                1615    
Thr Lys Ala Ile Thr Glu Ile Tyr Leu Thr Arg Leu Leu Ser Val Lys
            1620                1625                1630        
Gly Thr Leu Gln Gln Phe Val Asp Asn Phe Phe Gln Ser Val Leu Ala
        1635                1640                1645            
Pro Gly His Ala Val Pro Pro Ala Val Lys Tyr Phe Phe Asp Phe Leu
    1650                1655                1660                
Asp Glu Gln Ala Glu Lys His Asn Ile Gln Asp Glu Asp Thr Ile His
1665                1670                1675                1680
Ile Trp Lys Thr Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu
                1685                1690                1695    
Lys Asn Pro His Phe Ile Phe Asp Val His Val His Glu Val Val Asp
            1700                1705                1710        
Ala Ser Leu Ser Val Ile Ala Gln Thr Phe Met Asp Ala Cys Thr Arg
        1715                1720                1725            
Thr Glu His Lys Leu Ser Arg Asp Ser Pro Ser Asn Lys Leu Leu Tyr
    1730                1735                1740                
Ala Lys Glu Ile Ser Thr Tyr Lys Lys Met Val Glu Asp Tyr Tyr Lys
1745                1750                1755                1760
Gly Ile Arg Gln Met Val Gln Val Ser Asp Gln Asp Met Asn Thr His
                1765                1770                1775    
Leu Ala Glu Ile Ser Arg Ala His Thr Asp Ser Leu Asn Thr Leu Val
            1780                1785                1790        
Ala Leu His Gln Leu Tyr Gln Tyr Thr Gln Lys Tyr Tyr Asp Glu Ile
        1795                1800                1805            
Ile Asn Ala Leu Glu Glu Asp Pro Ala Ala Gln Lys Met Gln Leu Ala
    1810                1815                1820                
Phe Arg Leu Gln Gln Ile Ala Ala Ala Leu Glu Asn Lys Val Thr Asp
1825                1830                1835                1840
Leu
    


<210> 5649
<211> 747
<212> PRT
<213> Homo sapiens

<400> 5649
Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg
            20                  25                  30          
Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp
        35                  40                  45              
Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu
    50                  55                  60                  
Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp
65                  70                  75                  80  
Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu
                85                  90                  95      
Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp
            100                 105                 110         
Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr
        115                 120                 125             
Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln
    130                 135                 140                 
Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr
145                 150                 155                 160 
Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile
                165                 170                 175     
Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe
            180                 185                 190         
Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser
        195                 200                 205             
Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn
    210                 215                 220                 
Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu
225                 230                 235                 240 
Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg
                245                 250                 255     
Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu
            260                 265                 270         
Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro
        275                 280                 285             
Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu
    290                 295                 300                 
Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro
305                 310                 315                 320 
Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val
                325                 330                 335     
Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His
            340                 345                 350         
Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr
        355                 360                 365             
Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu
    370                 375                 380                 
Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe
385                 390                 395                 400 
Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val
                405                 410                 415     
Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala
            420                 425                 430         
Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly
        435                 440                 445             
Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met
    450                 455                 460                 
His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser
465                 470                 475                 480 
His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro
                485                 490                 495     
Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys
            500                 505                 510         
His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu
        515                 520                 525             
Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe
    530                 535                 540                 
Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala
545                 550                 555                 560 
Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser
                565                 570                 575     
Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr
            580                 585                 590         
Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys
        595                 600                 605             
Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His
    610                 615                 620                 
Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp
625                 630                 635                 640 
His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg
                645                 650                 655     
Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly
            660                 665                 670         
Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala
        675                 680                 685             
Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly
    690                 695                 700                 
Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser
705                 710                 715                 720 
Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg
                725                 730                 735     
Ala Leu Lys Gly His Ala Gly His Pro Ala Ala
            740                 745         


<210> 5650
<211> 793
<212> PRT
<213> Homo sapiens

<400> 5650
Ala Glu Asp Glu Glu Val Gln Gln Arg Leu Arg Ala Ala Pro Ser Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala
            20                  25                  30          
Pro Arg Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln
        35                  40                  45              
Ala Asp Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala
    50                  55                  60                  
Val Glu Phe Phe Ala Ser Trp Cys Gly His Ser Ile Ala Phe Ala Pro
65                  70                  75                  80  
Thr Trp Lys Ala Leu Ala Glu Asp Val Lys Arg Trp Arg Pro Ala Leu
                85                  90                  95      
Tyr Leu Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys
            100                 105                 110         
Arg Asp Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala
        115                 120                 125             
Phe Thr Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp
    130                 135                 140                 
Val Gln Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His
145                 150                 155                 160 
Asp Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu
                165                 170                 175     
Glu Ile Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu
            180                 185                 190         
Ile Phe Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp
        195                 200                 205             
Leu Ser Gln His Lys Gly Val Ala Val Ala Arg Val Val Asn Thr Glu
    210                 215                 220                 
Ala Asn Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr
225                 230                 235                 240 
Leu Leu Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu
                245                 250                 255     
Ser Arg Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr
            260                 265                 270         
Arg Glu Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile
        275                 280                 285             
Ala Pro Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala
    290                 295                 300                 
Asp Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg
305                 310                 315                 320 
Phe Pro Val Leu Glu Gly Gln Arg Leu Gly Gly Pro Glu Lys Val Cys
                325                 330                 335     
Gly Ser Ser Gly Gln Val Phe Pro Gly Arg Pro Leu Val Gln Asn Phe
            340                 345                 350         
Leu His Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile
        355                 360                 365             
Pro Tyr Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala
    370                 375                 380                 
Val Leu Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro
385                 390                 395                 400 
His Phe Arg Gly Phe Pro Cys Ser Cys Gly Ser Ser Ser Thr Ser Arg
                405                 410                 415     
Leu Cys Arg Gln Leu Gly Ser Lys Cys Arg Pro Leu Thr Gly Ser Thr
            420                 425                 430         
Gln Gly Gln Gly Gly Pro Pro Ser His Pro Arg Leu Ala Ala Leu Leu
        435                 440                 445             
Leu Arg Leu Pro Arg Leu Arg Lys Pro Leu Arg Ala Asp Ala Ala Ala
    450                 455                 460                 
Ser Met His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp
465                 470                 475                 480 
Ser Ser His Asn Arg Val Asn Ala Arg Leu Gln Val Pro Pro Ala Arg
                485                 490                 495     
Thr Pro Ser Ser Pro Arg Cys Ser Gly His Pro Val Asn Phe Val Leu
            500                 505                 510         
Pro Ala Thr Met Asn Ala Trp Met Cys Pro Cys Gly Thr Trp Lys Pro
        515                 520                 525             
Pro Ser Thr Ser Ser Arg Pro Thr Ser Pro Gln Ala Thr Ser Ser Trp
    530                 535                 540                 
Thr Ser Leu Gln Leu Gly Gln Leu Pro Glu Gly Cys Ala Glu Cys Ala
545                 550                 555                 560 
Ala Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn
                565                 570                 575     
Ser Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn
            580                 585                 590         
Thr Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro
        595                 600                 605             
Lys Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu
    610                 615                 620                 
His Met Ala Asp Val Gln Arg Asn Glu Gln Asp Glu Pro Leu Gly Gln
625                 630                 635                 640 
Trp His Leu Arg Ser Glu Thr Gln Gly Leu His Cys Trp Leu Ser Pro
                645                 650                 655     
Gly Leu Arg Arg Thr Ala Ser Gly Ala Leu Trp Arg Ser Gly Ala Trp
            660                 665                 670         
Ala Ala Ala Pro Ser Ser Trp Ser Thr Ser Leu Arg Pro Ala Gly Gly
        675                 680                 685             
Pro Ser Trp Thr Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly
    690                 695                 700                 
Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Pro Cys Pro
705                 710                 715                 720 
Ser Trp Ala Cys Trp His Val His Leu Leu Pro Gly Gln Asp Lys Ala
                725                 730                 735     
Leu Asn Arg Met Leu Ala Thr Leu Gln Pro Glu Pro Pro Gly Glu Glu
            740                 745                 750         
Ala Gly Glu Gly Ala Ala Ile Ser Arg His Leu Lys Pro Pro Asp Pro
        755                 760                 765             
Ile Pro Ser Pro Pro Thr Pro Cys Ser Leu Ser Gly Leu Glu Val Trp
    770                 775                 780                 
Glu Ile Gln Glu Asn Glu Leu Leu Gln
785                 790             


<210> 5651
<211> 788
<212> PRT
<213> Homo sapiens

<400> 5651
Ala Glu Asp Glu Glu Val Gln Gln Arg Leu Arg Ala Pro Ser Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro
            20                  25                  30          
Arg Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala
        35                  40                  45              
Asp Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val
    50                  55                  60                  
Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr
65                  70                  75                  80  
Trp Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr
                85                  90                  95      
Leu Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg
            100                 105                 110         
Asp Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe
        115                 120                 125             
Thr Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val
    130                 135                 140                 
Gln Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp
145                 150                 155                 160 
Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu
                165                 170                 175     
Ile Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile
            180                 185                 190         
Phe Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu
        195                 200                 205             
Ser Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala
    210                 215                 220                 
Asn Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu
225                 230                 235                 240 
Leu Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser
                245                 250                 255     
Arg Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg
            260                 265                 270         
Glu Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala
        275                 280                 285             
Pro Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp
    290                 295                 300                 
Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe
305                 310                 315                 320 
Pro Val Leu Glu Gly Gln Arg Gly Gly Pro Glu Lys Val Cys Gly Ser
                325                 330                 335     
Ala Gly Gln Ala Ser Ala Cys Ser Ser Pro Gln Tyr Phe Pro Gly Arg
            340                 345                 350         
Pro Leu Val Gln Asn Phe Leu His Ser Val Asn Glu Trp Leu Lys Arg
        355                 360                 365             
Gln Lys Arg Asn Lys Ile Pro Tyr Ser Phe Phe Lys Thr Ala Leu Asp
    370                 375                 380                 
Asp Arg Lys Glu Gly Ala Val Leu Ala Lys Lys Val Asn Trp Ile Gly
385                 390                 395                 400 
Cys Gln Gly Ser Glu Pro His Phe Arg Gly Phe Pro Cys Cys Gly Ser
                405                 410                 415     
Ser Ser Thr Ser Asp Cys Ala Gly Ser Ser Ala Lys Cys Arg Pro Leu
            420                 425                 430         
Thr Gly Ser Ser Gln Gly Gln Gly Gly Pro Pro Ser His Pro Arg Leu
        435                 440                 445             
Arg Ala Leu Leu Leu Arg Leu Pro Arg Leu Arg His Phe Glu Gln Met
    450                 455                 460                 
Ala Ala Ala Ser Met His Arg Val Gly Ser Pro Asn Ala Ala Val Leu
465                 470                 475                 480 
Trp Leu Trp Ser Ser His Asn Arg Val Asn Ala Arg Leu Ala Gly Pro
                485                 490                 495     
Ala Arg Thr Pro Ser Ser Pro Arg Cys Ser Gly His Pro Val Asn Phe
            500                 505                 510         
Val Leu Pro Ala Thr Met Asn Ala Trp Met Cys Pro Cys Gly Thr Trp
        515                 520                 525             
Lys Pro Pro Ser Thr Ser Ser Arg Pro Thr Ser Pro Gln Ala Thr Ser
    530                 535                 540                 
Ser Trp Thr Ser Leu Gln Leu Gly Gln Leu Pro Gly Gly Met Cys Arg
545                 550                 555                 560 
Ala Ala Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg
                565                 570                 575     
Asn Ser Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr
            580                 585                 590         
Asn Thr Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro
        595                 600                 605             
Pro Lys Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro
    610                 615                 620                 
Glu His Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly
625                 630                 635                 640 
Gln Trp His Leu Ser Glu Thr Gln Gly Leu His Cys Trp Leu Ser Pro
                645                 650                 655     
Gly Leu Arg Arg Thr Ala Ser Gly Ala Leu Trp Arg Ser Gly Ala Trp
            660                 665                 670         
Ala Ala Ala Pro Ser Ser Trp Ser Thr Ser Leu Pro Ala Gly Gly Pro
        675                 680                 685             
Ser Trp Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly Phe Ser
    690                 695                 700                 
Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Cys Pro Ser Trp Ala
705                 710                 715                 720 
Cys Trp Val His Leu Leu Pro Gly Gln Asp Lys Gly Arg Ala Met Leu
                725                 730                 735     
Ala Thr Leu Gln Pro Glu Pro Pro Gly Glu Glu Ala Gly Glu Gly Ala
            740                 745                 750         
Ala Ile Ser Arg His Leu Lys Pro Pro Asp Pro Ile Pro Ser Pro Pro
        755                 760                 765             
Thr Pro Cys Ser Leu Ser Gly Leu Glu Val Trp Glu Ile Gln Glu Asn
    770                 775                 780                 
Glu Leu Leu Gln
785             


<210> 5652
<211> 852
<212> PRT
<213> Homo sapiens

<400> 5652
Met Leu Pro Gly Thr Ser Thr Gly Asn Asn Gln Ser Thr Ile Thr Leu
 1               5                  10                  15      
Ser Val Ala Ser Gln Asn Leu Thr Phe Thr Ser Ser Ser Ser Pro Pro
            20                  25                  30          
Asn Gly Asp Ser Ile Asn Lys Asp Pro Lys Leu Cys Thr Lys Ser Pro
        35                  40                  45              
Arg Lys Arg Leu Ser Ser Thr Leu Gln Glu Thr Gln Val Pro Pro Val
    50                  55                  60                  
Lys Lys Pro Ile Val Glu Gln Leu Ser Ala Ala Thr Ile Glu Gly Gln
65                  70                  75                  80  
Lys Gln Gly Ser Val Lys Lys Asp Gln Lys Val Pro His Ser Gly Lys
                85                  90                  95      
Thr Glu Gly Ser Thr Ala Gly Ala Gln Ile Pro Ser Lys Val Ser Val
            100                 105                 110         
Asn Val Ser Ser His Ile Gly Ala Asn Gln Pro Leu Asn Ser Ser Ala
        115                 120                 125             
Leu Val Ile Ser Asp Ser Ala Leu Glu Gln Gln Thr Thr Pro Ser Ser
    130                 135                 140                 
Ser Pro Asp Ile Lys Val Lys Leu Glu Gly Ser Val Phe Leu Leu Asp
145                 150                 155                 160 
Ser Asp Ser Lys Ser Val Gly Ser Phe Asn Pro Asn Gly Trp Gln Gln
                165                 170                 175     
Ile Thr Lys Asp Ser Glu Phe Ile Ser Ala Ser Cys Glu Gln Gln Gln
            180                 185                 190         
Asp Ile Ser Val Met Thr Ile Pro Glu His Ser Asp Ile Asn Asp Leu
        195                 200                 205             
Glu Lys Ser Val Trp Glu Leu Glu Gly Met Pro Gln Asp Thr Tyr Ser
    210                 215                 220                 
Gln Gln Leu His Ser Gln Ile Gln Glu Ser Ser Leu Asn Gln Ile Gln
225                 230                 235                 240 
Ala His Ser Ser Asp Gln Leu Pro Leu Gln Ser Glu Leu Lys Glu Phe
                245                 250                 255     
Glu Pro Ser Val Ser Gln Thr Asn Glu Ser Tyr Phe Pro Phe Asp Asp
            260                 265                 270         
Glu Leu Thr Gln Asp Ser Ile Val Glu Glu Leu Val Leu Met Glu Gln
        275                 280                 285             
Gln Met Ser Met Asn Asn Ser His Ser Tyr Gly Asn Cys Leu Gly Met
    290                 295                 300                 
Thr Leu Gln Ser Gln Ser Val Thr Pro Gly Ala Pro Met Ser Ser His
305                 310                 315                 320 
Thr Ser Ser Thr His Phe Tyr His Pro Ile His Ser Asn Gly Thr Pro
                325                 330                 335     
Ile His Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro
            340                 345                 350         
Thr Pro Thr Pro Thr Ser Glu Met Ile Ala Gly Ser Gln Ser Leu Ser
        355                 360                 365             
Arg Glu Ser Pro Cys Ser Arg Leu Ala Gln Thr Thr Pro Val Asp Ser
    370                 375                 380                 
Ala Leu Gly Ser Ser Arg His Thr Pro Ile Gly Thr Pro His Ser Asn
385                 390                 395                 400 
Cys Ser Ser Ser Val Pro Pro Ser Pro Val Glu Cys Arg Asn Pro Phe
                405                 410                 415     
Ala Phe Thr Pro Ile Ser Ser Ser Met Ala Tyr His Asp Ala Ser Ile
            420                 425                 430         
Val Ser Ser Ser Pro Val Lys Pro Met Gln Arg Pro Met Ala Thr His
        435                 440                 445             
Pro Asp Lys Thr Lys Leu Glu Trp Met Asn Asn Gly Tyr Ser Gly Val
    450                 455                 460                 
Gly Asn Ser Ser Val Ser Gly His Gly Ile Leu Pro Ser Tyr Gln Glu
465                 470                 475                 480 
Leu Val Glu Asp Arg Phe Arg Lys Pro His Ala Phe Ala Val Pro Gly
                485                 490                 495     
Gln Ser Tyr Gln Ser Gln Ser Arg His His Asp Thr His Phe Gly Arg
            500                 505                 510         
Leu Thr Pro Val Ser Pro Val Gln His Gln Gly Ala Thr Val Asn Asn
        515                 520                 525             
Thr Asn Lys Gln Glu Gly Phe Ala Val Pro Ala Pro Leu Asp Asn Lys
    530                 535                 540                 
Gly Thr Asn Ser Ser Ala Ser Ser Asn Phe Arg Cys Arg Ser Val Ser
545                 550                 555                 560 
Pro Ala Val His Arg Gln Arg Asn Leu Ser Gly Ser Thr Leu Tyr Pro
                565                 570                 575     
Val Ser Asn Ile Pro Arg Ser Asn Val Thr Pro Phe Gly Ser Pro Val
            580                 585                 590         
Thr Pro Glu Val His Val Phe Thr Asn Val His Thr Asp Ala Cys Ala
        595                 600                 605             
Asn Asn Ile Ala Gln Arg Ser Gln Ser Val Pro Leu Thr Val Met Met
    610                 615                 620                 
Gln Thr Ala Phe Pro Asn Ala Leu Gln Lys Gln Ala Asn Ser Lys Lys
625                 630                 635                 640 
Ile Thr Asn Val Leu Leu Ser Lys Leu Asp Ser Asp Asn Asp Asp Ala
                645                 650                 655     
Val Arg Gly Leu Gly Met Asn Asn Leu Pro Ser Asn Tyr Thr Ala Arg
            660                 665                 670         
Met Asn Leu Thr Gln Ile Leu Glu Pro Ser Thr Val Phe Pro Ser Ala
        675                 680                 685             
Asn Pro Gln Asn Met Ile Asp Ser Ser Thr Ser Val Tyr Glu Phe Gln
    690                 695                 700                 
Thr Pro Ser Tyr Leu Thr Lys Ser Asn Ser Thr Gly Gln Ile Asn Phe
705                 710                 715                 720 
Ser Pro Gly Asp Asn Gln Ala Gln Ser Glu Ile Gly Glu Gln Gln Leu
                725                 730                 735     
Asp Phe Asn Ser Thr Val Lys Asp Leu Leu Ser Gly Asp Ser Leu Gln
            740                 745                 750         
Thr Asn Gln Gln Leu Val Gly Gln Gly Ala Ser Asp Leu Thr Asn Thr
        755                 760                 765             
Ala Ser Asp Phe Ser Ser Asp Ile Arg Leu Ser Ser Glu Leu Ser Gly
    770                 775                 780                 
Ser Ile Asn Asp Leu Asn Thr Leu Asp Pro Asn Leu Leu Phe Asp Pro
785                 790                 795                 800 
Gly Arg Gln Gln Gly Gln Asp Asp Glu Ala Thr Leu Glu Glu Leu Lys
                805                 810                 815     
Asn Asp Pro Leu Phe Gln Gln Ile Cys Ser Glu Ser Met Asn Ser Met
            820                 825                 830         
Thr Ser Ser Gly Phe Glu Trp Ile Glu Ser Lys Asp His Pro Thr Val
        835                 840                 845             
Glu Met Leu Gly
    850         


<210> 5653
<211> 972
<212> PRT
<213> Homo sapiens

<400> 5653
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His
 1               5                  10                  15      
Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val
            20                  25                  30          
Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val
        35                  40                  45              
Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly
    50                  55                  60                  
Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly
65                  70                  75                  80  
Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala
                85                  90                  95      
Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala
            100                 105                 110         
Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu
        115                 120                 125             
Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg
    130                 135                 140                 
Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His
145                 150                 155                 160 
Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln
                165                 170                 175     
Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg
            180                 185                 190         
Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val
        195                 200                 205             
Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys
    210                 215                 220                 
Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn
225                 230                 235                 240 
Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg
                245                 250                 255     
Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His
            260                 265                 270         
Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser
        275                 280                 285             
Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser
    290                 295                 300                 
Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn
305                 310                 315                 320 
Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp
                325                 330                 335     
Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala
            340                 345                 350         
Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu
        355                 360                 365             
Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg
    370                 375                 380                 
Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr
385                 390                 395                 400 
Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr
                405                 410                 415     
Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu
            420                 425                 430         
Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln
        435                 440                 445             
Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His
    450                 455                 460                 
Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn
465                 470                 475                 480 
Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp
                485                 490                 495     
Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu
            500                 505                 510         
Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu
        515                 520                 525             
Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro
    530                 535                 540                 
Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser
545                 550                 555                 560 
Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu
                565                 570                 575     
Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala
            580                 585                 590         
Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp
        595                 600                 605             
Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala
    610                 615                 620                 
Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu
625                 630                 635                 640 
Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly
                645                 650                 655     
Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu
            660                 665                 670         
Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser
        675                 680                 685             
Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu
    690                 695                 700                 
Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val
705                 710                 715                 720 
Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser
                725                 730                 735     
Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu
            740                 745                 750         
Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe
        755                 760                 765             
Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val
    770                 775                 780                 
Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala
785                 790                 795                 800 
Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg
                805                 810                 815     
Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr
            820                 825                 830         
Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile
        835                 840                 845             
Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys
    850                 855                 860                 
Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe
865                 870                 875                 880 
Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu
                885                 890                 895     
Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu
            900                 905                 910         
Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser
        915                 920                 925             
Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu
    930                 935                 940                 
Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala
945                 950                 955                 960 
Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys
                965                 970         


<210> 5654
<211> 488
<212> PRT
<213> Homo sapiens

<400> 5654
Pro His Gly Ile Lys Glu Gly Arg Glu Gly Ala Asp Leu Phe Gly Arg
 1               5                  10                  15      
Lys Thr Asp Phe Val Val Arg Phe Leu Gly Val Gln Glu Gln Val Lys
            20                  25                  30          
Gly Glu Arg Glu Glu Arg Gly Lys Ala Arg Gly Arg Glu Gly Glu Arg
        35                  40                  45              
Gly Ser Val Ala Gly Arg Gly Arg Arg Asp Leu Asn Gly Glu Cys Gln
    50                  55                  60                  
Pro Ile Pro Glu Thr His Arg Asp Leu Arg Thr Lys Ile Arg His His
65                  70                  75                  80  
Gly His His Thr Gly His Glu Leu Thr Gly Lys Ser Ser Trp Glu Asp
                85                  90                  95      
Gln Gly Arg Ala Ala Gly Ser Thr Gln Gly Arg Lys Met Arg Trp Leu
            100                 105                 110         
Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys Ala Ser Ala His
        115                 120                 125             
Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln Ser Pro Gly Tyr
    130                 135                 140                 
Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp Asn Ile Thr Val
145                 150                 155                 160 
Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His Phe Asn Leu Glu
                165                 170                 175     
Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val Glu Thr Glu Asp
            180                 185                 190         
Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr Asp Thr Glu Gln
        195                 200                 205             
Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser Phe Met Ser Ile
    210                 215                 220                 
Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Asp
225                 230                 235                 240 
Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys Glu Arg Glu Asp
                245                 250                 255     
Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr Ile Gly Gly Tyr
            260                 265                 270         
Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr Asp Asn Arg Thr
        275                 280                 285             
Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln Arg Thr Gly Val
    290                 295                 300                 
Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys Ser Ser Glu Cys
305                 310                 315                 320 
Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val Asn Leu Gln Phe
                325                 330                 335     
Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val Pro Cys Pro Tyr
            340                 345                 350         
Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu Gly Pro Phe Cys
        355                 360                 365             
Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser His Ser Val Leu
    370                 375                 380                 
Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg Gly Trp Arg Leu
385                 390                 395                 400 
Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu Gln Pro Pro Val
                405                 410                 415     
His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe Phe Lys Asp Gln
            420                 425                 430         
Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu Lys Asp Asn Val
        435                 440                 445             
Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp Gly Thr Trp Ser
    450                 455                 460                 
Asn Lys Ile Pro Thr Cys Lys Lys Asn Glu Ile Asp Leu Glu Ser Glu
465                 470                 475                 480 
Leu Lys Ser Glu Gln Val Thr Glu
                485             


<210> 5655
<211> 211
<212> PRT
<213> Homo sapiens

<400> 5655
Glu Tyr Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile
 1               5                  10                  15      
Lys Glu Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn
            20                  25                  30          
Asp Ile Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr
        35                  40                  45              
Ile Val Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu
    50                  55                  60                  
Asn Gln Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His Ser
65                  70                  75                  80  
Ser Arg Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn Phe
                85                  90                  95      
Ile Lys Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met Ser
            100                 105                 110         
Asn Met Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Arg
        115                 120                 125             
Gln Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe
    130                 135                 140                 
His Gly Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys
145                 150                 155                 160 
Gly Leu Leu His Asn Tyr Gly Val Tyr Thr Ser Gln Pro Leu Pro Arg
                165                 170                 175     
Leu Asp Pro Trp Ala His Gln Arg Gln Gly Ser Pro Pro Glu Glu Leu
            180                 185                 190         
Gly Thr Leu Ala Thr Leu Pro Ala Gly Leu Gly Phe Cys Met Ala Met
        195                 200                 205             
Asp Gly Thr
    210     


<210> 5656
<211> 763
<212> PRT
<213> Homo sapiens

<400> 5656
Met Asn Gln Lys Thr Ile Leu Val Leu Leu Ile Leu Ala Val Ile Thr
 1               5                  10                  15      
Ile Phe Ala Leu Val Cys Val Leu Leu Val Gly Arg Gly Gly Asp Gly
            20                  25                  30          
Gly Glu Pro Ser Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala
        35                  40                  45              
Gln Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser
    50                  55                  60                  
Arg Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly
65                  70                  75                  80  
Pro Gly Leu Val Asp Ala Ala Gln Ala Arg Pro Ser Asp Asn Cys Val
                85                  90                  95      
Phe Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His
            100                 105                 110         
Leu Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val
        115                 120                 125             
Phe Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly
    130                 135                 140                 
Pro Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His
145                 150                 155                 160 
Gly Gly Pro Leu Pro Tyr His Arg Arg Pro Val Leu Phe Gln Glu Tyr
                165                 170                 175     
Leu Asp Ile Asp Gln Met Ile Phe Asn Arg Glu Leu Pro Gln Ala Ser
            180                 185                 190         
Gly Leu Leu His His Cys Cys Phe Tyr Lys His Arg Gly Arg Asn Leu
        195                 200                 205             
Val Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala
    210                 215                 220                 
Thr Trp Phe Gly Leu Tyr Tyr Asn Ile Ser Gly Ala Gly Phe Phe Leu
225                 230                 235                 240 
His His Val Gly Leu Glu Leu Leu Val Asn His Lys Ala Leu Asp Pro
                245                 250                 255     
Ala Arg Trp Thr Ile Gln Lys Val Phe Tyr Gln Gly Arg Tyr Tyr Asp
            260                 265                 270         
Ser Leu Ala Gln Leu Glu Ala Gln Phe Glu Ala Gly Leu Val Asn Val
        275                 280                 285             
Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser
    290                 295                 300                 
Pro Val Pro Pro Gly Pro Ala Pro Pro Leu Gln Phe Tyr Pro Gln Gly
305                 310                 315                 320 
Pro Arg Phe Ser Val Gln Gly Ser Arg Val Ala Ser Ser Leu Trp Thr
                325                 330                 335     
Phe Ser Phe Gly Leu Gly Ala Phe Ser Gly Pro Arg Ile Phe Asp Val
            340                 345                 350         
Arg Phe Gln Gly Glu Arg Leu Val Tyr Glu Ile Ser Leu Gln Glu Ala
        355                 360                 365             
Leu Ala Ile Tyr Gly Gly Asn Ser Pro Ala Ala Met Thr Thr Arg Tyr
    370                 375                 380                 
Val Asp Gly Gly Phe Gly Met Gly Lys Tyr Thr Thr Pro Leu Thr Arg
385                 390                 395                 400 
Gly Val Asp Cys Pro Tyr Leu Ala Thr Tyr Val Asp Trp His Phe Leu
                405                 410                 415     
Leu Glu Ser Gln Ala Pro Lys Thr Ile Arg Asp Ala Phe Cys Val Phe
            420                 425                 430         
Glu Gln Asn Gln Gly Leu Pro Leu Arg Arg His His Ser Asp Leu Tyr
        435                 440                 445             
Ser His Tyr Phe Gly Gly Leu Ala Glu Thr Val Leu Val Val Arg Ser
    450                 455                 460                 
Met Ser Thr Leu Leu Asn Tyr Asp Tyr Val Trp Asp Thr Val Phe His
465                 470                 475                 480 
Pro Ser Gly Ala Ile Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser
                485                 490                 495     
Ser Ala Phe Leu Phe Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser
            500                 505                 510         
Glu His Thr Leu Gly Thr Val His Thr His Ser Ala His Phe Lys Val
        515                 520                 525             
Asp Leu Asp Val Ala Gly Leu Glu Asn Trp Val Trp Ala Glu Asp Met
    530                 535                 540                 
Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu Gln
545                 550                 555                 560 
Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala Ala
                565                 570                 575     
Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser Asn
            580                 585                 590         
His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met Leu
        595                 600                 605             
Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg Gly
    610                 615                 620                 
Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu Glu
625                 630                 635                 640 
Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala Pro
                645                 650                 655     
Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly Lys
            660                 665                 670         
Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His Ala
        675                 680                 685             
Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe Phe
    690                 695                 700                 
Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser Ala
705                 710                 715                 720 
Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu Val
                725                 730                 735     
Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp Leu
            740                 745                 750         
Pro Ala Phe Ser His Gly Gly Phe Ser His Asn
        755                 760             


<210> 5657
<211> 1445
<212> PRT
<213> Homo sapiens

<400> 5657
Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile
 1               5                  10                  15      
Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu
            20                  25                  30          
Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln
        35                  40                  45              
Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly
    50                  55                  60                  
Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Ser
65                  70                  75                  80  
Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly
                85                  90                  95      
Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser
            100                 105                 110         
Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu
        115                 120                 125             
Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys
    130                 135                 140                 
Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly
145                 150                 155                 160 
Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile
                165                 170                 175     
Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser
            180                 185                 190         
Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro
        195                 200                 205             
Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val
    210                 215                 220                 
Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp
225                 230                 235                 240 
Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu
                245                 250                 255     
Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg
            260                 265                 270         
Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe
        275                 280                 285             
Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn
    290                 295                 300                 
Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser
305                 310                 315                 320 
Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn
                325                 330                 335     
Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His
            340                 345                 350         
Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser
        355                 360                 365             
Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser
    370                 375                 380                 
Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys
385                 390                 395                 400 
Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp
                405                 410                 415     
Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg
            420                 425                 430         
Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile
        435                 440                 445             
Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro
    450                 455                 460                 
Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp
465                 470                 475                 480 
Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met
                485                 490                 495     
Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr
            500                 505                 510         
Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser
        515                 520                 525             
Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala
    530                 535                 540                 
Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala
545                 550                 555                 560 
Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly
                565                 570                 575     
Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu
            580                 585                 590         
Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys
        595                 600                 605             
Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser
    610                 615                 620                 
Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr
625                 630                 635                 640 
Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr
                645                 650                 655     
Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr
            660                 665                 670         
Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser
        675                 680                 685             
Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly
    690                 695                 700                 
Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu
705                 710                 715                 720 
Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu
                725                 730                 735     
Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu
            740                 745                 750         
Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile
        755                 760                 765             
Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly
    770                 775                 780                 
Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe
785                 790                 795                 800 
Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile
                805                 810                 815     
Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln
            820                 825                 830         
Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe
        835                 840                 845             
Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile
    850                 855                 860                 
Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr
865                 870                 875                 880 
Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu
                885                 890                 895     
Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val
            900                 905                 910         
Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu
        915                 920                 925             
Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr
    930                 935                 940                 
Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys
945                 950                 955                 960 
Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile
                965                 970                 975     
Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg
            980                 985                 990         
Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln Lys Gly Asn
        995                 1000                1005            
Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr His Tyr Thr
    1010                1015                1020                
Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu Pro Val Leu Thr
1025                1030                1035                1040
Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu Thr Gly Pro Val
                1045                1050                1055    
Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val
            1060                1065                1070        
Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser Thr Val Asn Val
        1075                1080                1085            
Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn Tyr Leu Val Gln
    1090                1095                1100                
Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Ile
1105                1110                1115                1120
Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu His Ser Tyr Val
                1125                1130                1135    
Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr Arg Leu Glu Lys
            1140                1145                1150        
Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr Val Glu Cys Phe
        1155                1160                1165            
Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg Asn Ser Ser Val
    1170                1175                1180                
Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro Leu Pro Gly Met
1185                1190                1195                1200
Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Arg
                1205                1210                1215    
Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro His Thr Thr Lys
            1220                1225                1230        
Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln Ile Ile Val Met
        1235                1240                1245            
Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe Val Tyr Trp Pro
    1250                1255                1260                
Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr Val Thr Leu Ile
1265                1270                1275                1280
Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln Ile Ile Ile His
                1285                1290                1295    
Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val Leu Glu Val Arg
            1300                1305                1310        
His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala Pro Ile Ser Ser
        1315                1320                1325            
Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala Leu Thr Arg Asp
    1330                1335                1340                
Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val Ser Ala Gly Met
1345                1350                1355                1360
Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu Asn Glu Asn Ala
                1365                1370                1375    
Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu Met Arg Pro Gly
            1380                1385                1390        
Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr Lys Ala Arg Leu
        1395                1400                1405            
Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro Met Thr Val Asp
    1410                1415                1420                
Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp Pro Ala Glu Ser
1425                1430                1435                1440
Met Glu Ser Leu Val
                1445


<210> 5658
<211> 402
<212> PRT
<213> Homo sapiens

<400> 5658
Cys Ser Ser Lys Ser Phe Lys Leu Tyr Ser Pro Lys Glu Pro Pro Asn
 1               5                  10                  15      
Gly Asn Ala Phe Pro Pro Phe His Pro Gly Thr Met Leu Asp Arg Asp
            20                  25                  30          
Val Gly Pro Thr Pro Met Tyr Pro Pro Thr Tyr Leu Glu Pro Gly Ile
        35                  40                  45              
Gly Arg His Thr Pro Tyr Gly Asn Gln Thr Asp Tyr Arg Ile Phe Glu
    50                  55                  60                  
Leu Asn Lys Arg Leu Gln Asn Trp Thr Glu Glu Cys Asp Asn Leu Trp
65                  70                  75                  80  
Trp Asp Ala Phe Thr Thr Glu Phe Phe Glu Asp Asp Ala Met Leu Thr
                85                  90                  95      
Ile Thr Phe Cys Leu Glu Asp Gly Pro Lys Arg Tyr Thr Ile Gly Arg
            100                 105                 110         
Thr Leu Ile Pro Arg Tyr Phe Arg Ser Ile Phe Glu Gly Gly Ala Thr
        115                 120                 125             
Glu Leu Tyr Tyr Val Leu Lys His Pro Lys Glu Ala Phe His Ser Asn
    130                 135                 140                 
Phe Val Ser Leu Asp Cys Asp Gln Gly Ser Met Val Thr Gln His Gly
145                 150                 155                 160 
Lys Pro Met Phe Thr Gln Val Cys Val Glu Gly Arg Leu Tyr Leu Glu
                165                 170                 175     
Phe Met Phe Asp Asp Met Met Arg Ile Lys Thr Trp His Phe Ser Ile
            180                 185                 190         
Arg Gln His Arg Glu Leu Ile Pro Arg Ser Ile Leu Ala Met His Ala
        195                 200                 205             
Gln Asp Pro Gln Met Leu Asp Gln Leu Ser Lys Asn Ile Thr Arg Cys
    210                 215                 220                 
Gly Leu Ser Asn Ser Thr Leu Asn Tyr Leu Arg Leu Cys Val Ile Leu
225                 230                 235                 240 
Glu Pro Met Gln Glu Leu Met Ser Arg His Lys Thr Tyr Ser Leu Ser
                245                 250                 255     
Pro Arg Asp Cys Leu Lys Thr Cys Leu Phe Gln Lys Trp Gln Arg Met
            260                 265                 270         
Val Ala Pro Pro Ala Glu Pro Thr Arg Gln Gln Pro Ser Lys Arg Arg
        275                 280                 285             
Lys Arg Lys Met Ser Gly Gly Ser Thr Met Ser Ser Gly Gly Gly Asn
    290                 295                 300                 
Thr Asn Asn Ser Asn Ser Lys Lys Lys Ser Pro Ala Ser Thr Phe Ala
305                 310                 315                 320 
Leu Ser Ser Gln Val Pro Asp Val Met Val Val Gly Glu Pro Thr Leu
                325                 330                 335     
Met Gly Gly Glu Phe Gly Asp Glu Asp Glu Arg Leu Ile Thr Arg Leu
            340                 345                 350         
Glu Asn Thr Gln Phe Asp Ala Ala Asn Gly Ile Asp Asp Glu Asp Ser
        355                 360                 365             
Phe Asn Asn Ser Pro Ala Leu Gly Ala Asn Ser Pro Trp Asn Ser Lys
    370                 375                 380                 
Pro Pro Ser Ser Gln Glu Ser Lys Ser Glu Asn Pro Thr Ser Gln Ala
385                 390                 395                 400 
Ser Gln
        


<210> 5659
<211> 1939
<212> PRT
<213> Homo sapiens

<400> 5659
Met Ser Ser Asp Ser Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Phe
 1               5                  10                  15      
Leu Arg Lys Ser Glu Arg Glu Arg Ile Glu Ala Gln Asn Lys Pro Phe
            20                  25                  30          
Asp Ala Lys Thr Ser Val Phe Val Val Asp Pro Lys Glu Ser Phe Val
        35                  40                  45              
Lys Ala Thr Val Gln Ser Arg Glu Gly Gly Lys Val Thr Ala Lys Thr
    50                  55                  60                  
Glu Ala Gly Ala Thr Val Thr Val Lys Asp Asp Gln Val Phe Pro Met
65                  70                  75                  80  
Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His
                85                  90                  95      
Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Thr Ala Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu
        195                 200                 205             
Glu Val Thr Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile
    210                 215                 220                 
Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg
225                 230                 235                 240 
Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly
                245                 250                 255     
Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu
            260                 265                 270         
Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile
        275                 280                 285             
Phe Tyr Gln Ile Met Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu
    290                 295                 300                 
Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu
305                 310                 315                 320 
Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp
                325                 330                 335     
Ser Ala Ile Glu Ile Leu Gly Phe Thr Ser Asp Glu Arg Val Ser Ile
            340                 345                 350         
Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys
        355                 360                 365             
Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala
    370                 375                 380                 
Asp Lys Ala Ala Tyr Leu Gln Asn Leu Asn Ser Ala Asp Leu Leu Lys
385                 390                 395                 400 
Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys
                405                 410                 415     
Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys
            420                 425                 430         
Ala Val Tyr Asp Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln
        435                 440                 445             
Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp
    450                 455                 460                 
Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys
465                 470                 475                 480 
Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met
                485                 490                 495     
Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr
            500                 505                 510         
Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu
        515                 520                 525             
Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro
    530                 535                 540                 
Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Glu Gln His Leu
545                 550                 555                 560 
Gly Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Pro
                565                 570                 575     
Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn
            580                 585                 590         
Ile Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val
        595                 600                 605             
Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Leu Leu Phe
    610                 615                 620                 
Val Gly Ala Thr Gly Ala Glu Ala Glu Ala Gly Gly Gly Lys Lys Gly
625                 630                 635                 640 
Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg
                645                 650                 655     
Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His
            660                 665                 670         
Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met
        675                 680                 685             
Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu
    690                 695                 700                 
Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala
705                 710                 715                 720 
Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu
                725                 730                 735     
Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Gly Ser
            740                 745                 750         
Ile Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe
        755                 760                 765             
Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys
    770                 775                 780                 
Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Met Cys Arg Gly Phe Leu
785                 790                 795                 800 
Ala Arg Val Glu Tyr Gln Lys Met Val Glu Arg Arg Glu Ser Ile Phe
                805                 810                 815     
Cys Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro
            820                 825                 830         
Trp Met Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu
        835                 840                 845             
Thr Glu Lys Glu Met Ala Asn Met Lys Glu Glu Phe Glu Lys Thr Lys
    850                 855                 860                 
Glu Glu Leu Ala Lys Thr Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys
865                 870                 875                 880 
Met Val Thr Leu Met Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln
                885                 890                 895     
Ala Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu
            900                 905                 910         
Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu
        915                 920                 925             
Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys
    930                 935                 940                 
Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp
945                 950                 955                 960 
Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu
                965                 970                 975     
Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr
            980                 985                 990         
Ile Ala Lys Leu Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala His Gln
        995                 1000                1005            
Gln Thr Leu Asp Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Thr Leu
    1010                1015                1020                
Thr Lys Ala Lys Ile Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly
1025                1030                1035                1040
Ser Leu Glu Gln Glu Lys Lys Ile Arg Met Asp Leu Glu Arg Ala Lys
                1045                1050                1055    
Arg Lys Leu Glu Gly Asp Leu Lys Leu Ala Gln Glu Ser Ala Met Asp
            1060                1065                1070        
Ile Glu Asn Asp Lys Gln Gln Leu Asp Glu Lys Leu Lys Lys Lys Glu
        1075                1080                1085            
Phe Glu Met Ser Gly Leu Gln Ser Lys Ile Glu Asp Glu Gln Ala Leu
    1090                1095                1100                
Gly Met Gln Leu Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu
1105                1110                1115                1120
Glu Leu Glu Glu Glu Ile Glu Ala Glu Arg Ala Ser Arg Ala Lys Ala
                1125                1130                1135    
Glu Lys Gln Arg Ser Asp Leu Ser Arg Glu Leu Glu Glu Ile Ser Glu
            1140                1145                1150        
Arg Leu Glu Glu Ala Gly Gly Ala Thr Ser Ala Gln Ile Glu Met Asn
        1155                1160                1165            
Lys Lys Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu
    1170                1175                1180                
Ala Thr Leu Gln His Glu Ala Thr Ala Ala Thr Leu Arg Lys Lys His
1185                1190                1195                1200
Ala Asp Ser Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg
                1205                1210                1215    
Val Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Met Lys Met Glu Ile
            1220                1225                1230        
Asp Asp Leu Ala Ser Asn Met Glu Thr Val Ser Lys Ala Lys Gly Asn
        1235                1240                1245            
Leu Glu Lys Met Cys Arg Ala Leu Glu Asp Gln Leu Ser Glu Ile Lys
    1250                1255                1260                
Thr Lys Glu Glu Glu Gln Gln Arg Leu Ile Asn Asp Leu Thr Ala Gln
1265                1270                1275                1280
Arg Ala Arg Leu Gln Thr Glu Ser Gly Glu Tyr Ser Arg Gln Leu Asp
                1285                1290                1295    
Glu Lys Asp Thr Leu Val Ser Gln Leu Ser Arg Gly Lys Gln Ala Phe
            1300                1305                1310        
Thr Gln Gln Ile Glu Glu Leu Lys Arg Gln Leu Glu Glu Glu Ile Lys
        1315                1320                1325            
Ala Lys Ser Ala Leu Ala His Ala Leu Gln Ser Ser Arg His Asp Cys
    1330                1335                1340                
Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Ala Lys Ala Glu
1345                1350                1355                1360
Leu Gln Arg Ala Met Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg
                1365                1370                1375    
Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu
            1380                1385                1390        
Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln Asp Ala Glu Glu His Val
        1395                1400                1405            
Glu Ala Val Asn Ala Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg
    1410                1415                1420                
Leu Gln Asn Glu Val Glu Asp Leu Met Ile Asp Val Glu Arg Thr Asn
1425                1430                1435                1440
Ala Ala Cys Ala Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Ile
                1445                1450                1455    
Leu Ala Glu Trp Lys Gln Lys Cys Glu Glu Thr His Ala Glu Leu Glu
            1460                1465                1470        
Ala Ser Gln Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Ile
        1475                1480                1485            
Lys Asn Ala Tyr Glu Glu Ser Leu Asp Gln Leu Glu Thr Leu Lys Arg
    1490                1495                1500                
Glu Asn Lys Asn Leu Gln Gln Glu Ile Ser Asp Leu Thr Glu Gln Ile
1505                1510                1515                1520
Ala Glu Gly Gly Lys Arg Ile His Glu Leu Glu Lys Ile Lys Lys Gln
                1525                1530                1535    
Val Glu Gln Glu Lys Ser Glu Leu Gln Ala Ala Leu Glu Glu Ala Glu
            1540                1545                1550        
Ala Ser Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ile Gln Leu Glu
        1555                1560                1565            
Leu Asn Gln Val Lys Ser Glu Val Asp Arg Lys Ile Ala Glu Lys Asp
    1570                1575                1580                
Glu Glu Ile Asp Gln Met Lys Arg Asn His Ile Arg Ile Val Glu Ser
1585                1590                1595                1600
Met Gln Ser Thr Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp Ala Ile
                1605                1610                1615    
Arg Leu Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln
            1620                1625                1630        
Leu Asn His Ala Asn Arg Met Ala Ala Glu Ala Leu Arg Asn Tyr Arg
        1635                1640                1645            
Asn Thr Gln Ala Ile Leu Lys Asp Thr Gln Leu His Leu Asp Asp Ala
    1650                1655                1660                
Leu Arg Ser Gln Glu Asp Leu Lys Glu Gln Leu Ala Met Val Glu Arg
1665                1670                1675                1680
Arg Ala Asn Leu Leu Gln Ala Glu Ile Glu Glu Leu Arg Ala Thr Leu
                1685                1690                1695    
Glu Gln Thr Glu Arg Ser Arg Lys Ile Ala Glu Gln Glu Leu Leu Asp
            1700                1705                1710        
Ala Ser Glu Arg Val Gln Leu Leu His Thr Gln Asn Thr Ser Leu Ile
        1715                1720                1725            
Asn Thr Lys Lys Lys Leu Glu Thr Asp Ile Ser Gln Ile Gln Gly Glu
    1730                1735                1740                
Met Glu Asp Ile Ile Gln Glu Ala Arg Asn Ala Glu Glu Lys Ala Lys
1745                1750                1755                1760
Lys Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu
                1765                1770                1775    
Gln Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln
            1780                1785                1790        
Thr Val Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala
        1795                1800                1805            
Leu Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Ala Arg Val Arg
    1810                1815                1820                
Glu Leu Glu Gly Glu Val Glu Ser Glu Gln Lys Arg Asn Val Glu Ala
1825                1830                1835                1840
Val Lys Gly Leu Arg Lys His Glu Arg Lys Val Lys Glu Leu Thr Tyr
                1845                1850                1855    
Gln Thr Glu Glu Asp Arg Lys Asn Ile Leu Arg Leu Gln Asp Leu Val
            1860                1865                1870        
Asp Lys Leu Gln Ala Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu
        1875                1880                1885            
Ala Glu Glu Gln Ser Asn Val Asn Leu Ser Lys Phe Arg Arg Ile Gln
    1890                1895                1900                
His Glu Leu Glu Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln
1905                1910                1915                1920
Val Asn Lys Leu Arg Val Lys Ser Arg Glu Val His Thr Lys Ile Ile
                1925                1930                1935    
Ser Glu Glu
            


<210> 5660
<211> 585
<212> PRT
<213> Homo sapiens

<400> 5660
Glu Leu Leu Thr Phe Lys Asp Val Ser Val Asp Phe Thr Gln Glu Glu
 1               5                  10                  15      
Trp Gly Gln Leu Ala Pro Ala His Arg Asn Leu Tyr Arg Glu Val Met
            20                  25                  30          
Leu Glu Asn Tyr Gly Asn Leu Val Ser Val Gly Pro Ile Gly Leu Pro
        35                  40                  45              
Arg Lys Arg Asp Arg Lys Tyr Asp Thr Pro Gly Lys Arg Ser Arg Tyr
    50                  55                  60                  
Asn Ile Asp Leu Val Asn His Ser Arg Ser Tyr Thr Lys Met Lys Thr
65                  70                  75                  80  
Phe Glu Cys Asn Ile Cys Glu Lys Ile Phe Lys Gln Leu Ile His Leu
                85                  90                  95      
Thr Glu His Met Arg Ile His Thr Gly Glu Lys Pro Phe Arg Cys Lys
            100                 105                 110         
Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu Ile Pro His Gln
        115                 120                 125             
Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys
    130                 135                 140                 
Thr Phe Arg His Pro Ser Ser Leu Thr Gln His Val Arg Ile His Thr
145                 150                 155                 160 
Gly Glu Lys Pro Tyr Glu Cys Arg Val Cys Glu Lys Ala Phe Ser Gln
                165                 170                 175     
Ser Ile Gly Leu Ile Gln His Leu Arg Thr His Val Arg Glu Lys Pro
            180                 185                 190         
Phe Thr Cys Lys Asp Cys Gly Lys Ala Phe Phe Gln Ile Arg His Leu
        195                 200                 205             
Arg Gln His Glu Ile Ile His Thr Gly Val Lys Pro Tyr Ile Cys Asn
    210                 215                 220                 
Val Cys Ser Lys Thr Phe Ser His Ser Thr Tyr Leu Thr Gln His Gln
225                 230                 235                 240 
Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Lys Glu Cys Gly Lys
                245                 250                 255     
Ala Phe Ser Gln Arg Ile His Leu Ser Ile His Gln Arg Val His Thr
            260                 265                 270         
Gly Val Lys Pro Tyr Glu Cys Ser His Cys Gly Lys Ala Phe Arg His
        275                 280                 285             
Asp Ser Ser Phe Ala Lys His Gln Arg Ile His Thr Gly Glu Lys Pro
    290                 295                 300                 
Tyr Asp Cys Asn Glu Cys Lys Glu Cys Gly Arg Ala Phe Ser Gln Ser
305                 310                 315                 320 
Ala Ser Leu Ser Thr His Gln Arg Ile His Thr Gly Glu Lys Pro Phe
                325                 330                 335     
Glu Cys Glu Glu Cys Gly Lys Ala Phe Arg His Arg Ser Ser Leu Asn
            340                 345                 350         
Gln His His Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Asp Lys
        355                 360                 365             
Cys Gln Lys Ala Phe Ser Gln Asn Ile Ser Leu Val Gln His Leu Arg
    370                 375                 380                 
Thr His Ser Gly Glu Lys Pro Phe Thr Cys Asn Glu Cys Gly Lys Thr
385                 390                 395                 400 
Phe Arg Gln Ile Arg His Leu Ser Glu His Ile Arg Ile His Thr Gly
                405                 410                 415     
Glu Lys Pro Tyr Ala Cys Thr Ala Cys Cys Lys Thr Phe Ser His Arg
            420                 425                 430         
Ala Tyr Leu Thr His His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr
        435                 440                 445             
Lys Cys Lys Glu Cys Gly Lys Ala Phe Arg Gln Arg Ile His Leu Ser
    450                 455                 460                 
Asn His Lys Thr Val His Thr Gly Val Lys Ala Tyr Glu Cys Asn Arg
465                 470                 475                 480 
Cys Gly Lys Ala Tyr Arg His Asp Ser Ser Phe Lys Lys His Gln Arg
                485                 490                 495     
His His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala
            500                 505                 510         
Phe Ser Tyr Asn Ser Ser Leu Thr Gln Leu Val Val His Gln Arg Leu
        515                 520                 525             
His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Gln Cys Gly Lys Thr Phe
    530                 535                 540                 
Thr Trp Asn Ser Ser Phe Asn Gln His Val Lys Ser His Thr Leu Glu
545                 550                 555                 560 
Lys Ser Phe Glu Cys Lys Glu Cys Gly Lys Thr Phe Arg Tyr Ser Ser
                565                 570                 575     
Ser Leu Tyr Lys His Ser Arg Phe His
            580                 585 


<210> 5661
<211> 505
<212> PRT
<213> Homo sapiens

<400> 5661
Met Pro Gln Gln Leu Leu Ile Thr Leu Pro Thr Glu Ala Ser Thr Trp
 1               5                  10                  15      
Val Lys Leu Gln His Pro Lys Lys Ala Val Glu Gly Ala Pro Leu Trp
            20                  25                  30          
Glu Asp Val Thr Lys Met Phe Glu Gly Glu Ala Leu Leu Ser Gln Asp
        35                  40                  45              
Ala Glu Asp Val Lys Thr Gln Arg Glu Ser Leu Glu Asp Glu Val Thr
    50                  55                  60                  
Pro Gly Leu Pro Thr Ala Glu Ser Gln Glu Leu Leu Thr Phe Lys Asp
65                  70                  75                  80  
Ile Ser Ile Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Ala Pro Ala
                85                  90                  95      
His Gln Asn Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Ser Asn Leu
            100                 105                 110         
Val Ser Val Gly Tyr Gln Leu Ser Lys Pro Ser Val Ile Ser Gln Leu
        115                 120                 125             
Glu Lys Gly Glu Glu Pro Trp Met Ala Glu Lys Glu Gly Pro Gly Asp
    130                 135                 140                 
Pro Ser Ser Asp Leu Lys Ser Lys Ile Glu Thr Ile Glu Ser Thr Ala
145                 150                 155                 160 
Lys Ser Thr Ile Ser Gln Glu Arg Leu Tyr His Gly Ile Met Met Glu
                165                 170                 175     
Ser Phe Met Arg Asp Asp Ile Ile Tyr Ser Thr Leu Arg Lys Val Ser
            180                 185                 190         
Thr Tyr Asp Asp Val Leu Glu Arg His Gln Glu Thr Cys Met Arg Asp
        195                 200                 205             
Val Arg Gln Ala Ile Leu Thr His Lys Lys Arg Val Gln Glu Thr Asn
    210                 215                 220                 
Lys Phe Gly Glu Asn Ile Ile Val His Ser Asn Val Ile Ile Glu Gln
225                 230                 235                 240 
Arg His His Lys Tyr Asp Thr Pro Thr Lys Arg Asn Thr Tyr Lys Leu
                245                 250                 255     
Asp Leu Ile Asn His Pro Thr Ser Tyr Ile Arg Thr Lys Thr Tyr Glu
            260                 265                 270         
Cys Asn Ile Cys Glu Lys Ile Phe Lys Gln Pro Ile His Leu Thr Glu
        275                 280                 285             
His Met Arg Ile His Thr Gly Glu Lys Pro Phe Arg Cys Lys Glu Cys
    290                 295                 300                 
Gly Arg Ala Phe Ser Gln Ser Ala Ser Leu Ser Thr His Gln Arg Ile
305                 310                 315                 320 
His Thr Gly Glu Lys Pro Phe Glu Cys Glu Glu Cys Gly Lys Ala Phe
                325                 330                 335     
Arg His Arg Ser Ser Leu Asn Gln His His Arg Thr His Thr Gly Glu
            340                 345                 350         
Lys Pro Tyr Val Cys Asp Lys Cys Gln Lys Ala Phe Ser Gln Asn Ile
        355                 360                 365             
Ser Leu Val Gln His Leu Arg Thr His Ser Gly Glu Lys Pro Phe Thr
    370                 375                 380                 
Cys Asn Glu Cys Gly Lys Thr Phe Arg Gln Ile Arg His Leu Ser Glu
385                 390                 395                 400 
His Ile Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys Thr Ala Cys
                405                 410                 415     
Cys Lys Thr Phe Ser His Arg Ala Tyr Leu Thr His His Gln Arg Ile
            420                 425                 430         
His Thr Gly Glu Arg Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe
        435                 440                 445             
Arg Gln Arg Ile His Leu Ser Asn His Lys Thr Val His Thr Gly Val
    450                 455                 460                 
Lys Ala Tyr Glu Cys Asn Arg Cys Gly Lys Ala Tyr Arg His Asp Ser
465                 470                 475                 480 
Ser Phe Lys Lys His Gln Arg His His Thr Gly Glu Lys Pro Tyr Glu
                485                 490                 495     
Cys Asn Glu Cys Gly Lys Ala Phe Ser
            500                 505 


<210> 5662
<211> 611
<212> PRT
<213> Homo sapiens

<400> 5662
Leu Thr Phe Lys Asp Val Ser Val Asp Phe Thr Gln Glu Glu Trp Gly
 1               5                  10                  15      
Gln Leu Ala Pro Ala His Arg Asn Leu Tyr Arg Glu Val Met Leu Glu
            20                  25                  30          
Asn Tyr Gly Asn Leu Val Ser Val Gly Cys Gln Leu Ser Lys Pro Gly
        35                  40                  45              
Val Ile Ser Gln Leu Glu Lys Gly Glu Glu Pro Trp Leu Met Glu Arg
    50                  55                  60                  
Asp Ile Ser Gly Val Pro Ser Ser Gly Lys Cys Lys Ala Asp Leu Lys
65                  70                  75                  80  
Ser Lys Thr Lys Thr Lys Glu Ser Ala Leu Gln Asn Asp Ile Ser Trp
                85                  90                  95      
Glu Glu Leu His Cys Gly Leu Met Met Glu Arg Phe Thr Lys Gly Ser
            100                 105                 110         
Ser Met Tyr Ser Thr Leu Gly Arg Ile Ser Lys Cys Asn Lys Leu Glu
        115                 120                 125             
Ser Gln Gln Glu Asn Gln Arg Met Gly Lys Gly Gln Ile Pro Leu Met
    130                 135                 140                 
Cys Lys Lys Thr Phe Thr Gln Glu Arg Gly Gln Glu Ser Asn Arg Phe
145                 150                 155                 160 
Glu Lys Arg Ile Asn Val Lys Ser Glu Val Met Pro Gly Pro Ile Gly
                165                 170                 175     
Leu Pro Arg Lys Arg Asp Arg Lys Tyr Asp Thr Pro Gly Lys Arg Ser
            180                 185                 190         
Arg Tyr Asn Ile Asp Leu Val Asn His Ser Arg Ser Tyr Thr Lys Met
        195                 200                 205             
Lys Thr Phe Glu Cys Asn Ile Cys Glu Lys Ile Phe Lys Gln Leu Ile
    210                 215                 220                 
His Leu Thr Glu His Met Arg Ile His Thr Gly Glu Lys Pro Phe Arg
225                 230                 235                 240 
Cys Lys Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu Ile Pro
                245                 250                 255     
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys
            260                 265                 270         
Gly Lys Thr Phe Arg His Pro Ser Ser Leu Thr Gln His Val Arg Ile
        275                 280                 285             
His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Val Cys Glu Lys Ala Phe
    290                 295                 300                 
Ser Gln Ser Ile Gly Leu Ile Gln His Leu Arg Thr His Val Arg Glu
305                 310                 315                 320 
Lys Pro Phe Thr Cys Lys Asp Cys Gly Lys Ala Phe Phe Gln Ile Arg
                325                 330                 335     
His Leu Arg Gln His Glu Ile Ile His Thr Gly Val Lys Pro Tyr Ile
            340                 345                 350         
Cys Asn Val Cys Ser Lys Thr Phe Ser His Ser Thr Tyr Leu Thr Gln
        355                 360                 365             
His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Lys Glu Cys
    370                 375                 380                 
Gly Lys Ala Phe Ser Gln Arg Ile His Leu Ser Ile His Gln Arg Val
385                 390                 395                 400 
His Thr Gly Val Lys Pro Tyr Glu Cys Ser His Cys Gly Lys Ala Phe
                405                 410                 415     
Arg His Asp Ser Ser Phe Ala Lys His Gln Arg Ile His Thr Gly Glu
            420                 425                 430         
Lys Pro Tyr Asp Cys Asn Glu Cys Gly Lys Ala Phe Ser Cys Ser Ser
        435                 440                 445             
Ser Leu Ile Arg His Cys Lys Thr His Leu Arg Asn Thr Phe Ser Asn
    450                 455                 460                 
Val Val Ile His Thr Gly Glu Lys Pro Phe Arg Cys Lys Glu Cys Gly
465                 470                 475                 480 
Arg Ala Phe Ser Gln Ser Ala Ser Leu Ser Thr His Gln Arg Ile His
                485                 490                 495     
Thr Gly Glu Lys Pro Phe Glu Cys Glu Glu Cys Gly Lys Ala Phe Arg
            500                 505                 510         
His Arg Ser Ser Leu Asn Gln His His Arg Thr His Thr Gly Glu Lys
        515                 520                 525             
Pro Tyr Val Cys Asp Lys Cys Gln Lys Ala Phe Ser Gln Asn Ile Ser
    530                 535                 540                 
Leu Val Gln His Leu Arg Thr His Ser Gly Glu Lys Pro Phe Thr Cys
545                 550                 555                 560 
Asn Glu Cys Gly Lys Thr Phe Arg Gln Ile Arg His Leu Ser Glu His
                565                 570                 575     
Ile Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys Thr Ala Cys Cys
            580                 585                 590         
Lys Thr Phe Ser His Arg Ala Tyr Leu Thr His His Gln Arg Ile His
        595                 600                 605             
Thr Gly Glu
    610     


<210> 5663
<211> 526
<212> PRT
<213> Homo sapiens

<400> 5663
Met Pro Gln Gln Leu Leu Ile Thr Leu Pro Thr Glu Ala Ser Thr Trp
 1               5                  10                  15      
Val Lys Leu Gln His Pro Lys Lys Ala Val Glu Gly Ala Pro Leu Trp
            20                  25                  30          
Glu Asp Val Thr Lys Met Phe Glu Gly Glu Ala Leu Leu Ser Gln Asp
        35                  40                  45              
Ala Glu Asp Val Lys Thr Gln Arg Glu Ser Leu Glu Asp Glu Val Thr
    50                  55                  60                  
Pro Gly Leu Pro Thr Ala Glu Ser Gln Glu Leu Leu Thr Phe Lys Asp
65                  70                  75                  80  
Ile Ser Ile Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Ala Pro Ala
                85                  90                  95      
His Gln Asn Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Ser Asn Leu
            100                 105                 110         
Val Ser Val Gly Tyr Gln Leu Ser Lys Pro Ser Val Ile Ser Gln Leu
        115                 120                 125             
Glu Lys Gly Glu Glu Pro Trp Met Ala Glu Lys Glu Gly Pro Gly Asp
    130                 135                 140                 
Pro Ser Ser Asp Leu Lys Ser Lys Ile Glu Thr Ile Glu Ser Thr Ala
145                 150                 155                 160 
Lys Ser Thr Ile Ser Gln Glu Arg Leu Tyr His Gly Ile Met Met Glu
                165                 170                 175     
Ser Phe Met Arg Asp Asp Ile Ile Tyr Ser Thr Leu Arg Lys Val Ser
            180                 185                 190         
Thr Tyr Asp Asp Val Leu Glu Arg His Gln Glu Thr Cys Met Arg Asp
        195                 200                 205             
Val Arg Gln Ala Ile Leu Thr His Lys Lys Arg Val Gln Glu Thr Asn
    210                 215                 220                 
Lys Phe Gly Glu Asn Ile Ile Val His Ser Asn Val Ile Ile Glu Gln
225                 230                 235                 240 
Arg His His Lys Tyr Asp Thr Pro Thr Lys Arg Asn Thr Tyr Lys Leu
                245                 250                 255     
Asp Leu Ile Asn His Pro Thr Ser Tyr Ile Arg Thr Lys Thr Tyr Glu
            260                 265                 270         
Cys Asn Ile Cys Glu Lys Ile Phe Lys Gln Pro Ile His Leu Thr Glu
        275                 280                 285             
His Met Arg Ile His Thr Gly Glu Lys Pro Phe Arg Cys Lys Glu Cys
    290                 295                 300                 
Gly Arg Ala Phe Ser Gln Ser Ala Ser Leu Ser Thr His Gln Arg Ile
305                 310                 315                 320 
His Thr Gly Glu Lys Pro Phe Glu Cys Glu Glu Cys Gly Lys Ala Phe
                325                 330                 335     
Arg His Arg Ser Ser Leu Asn Gln His His Arg Thr His Thr Gly Glu
            340                 345                 350         
Lys Pro Tyr Val Cys Asp Lys Cys Gln Lys Ala Phe Ser Gln Asn Ile
        355                 360                 365             
Ser Leu Val Gln His Leu Arg Thr His Ser Gly Glu Lys Pro Phe Thr
    370                 375                 380                 
Cys Asn Glu Cys Gly Lys Thr Phe Arg Gln Ile Arg His Leu Ser Glu
385                 390                 395                 400 
His Ile Arg Ile His Thr Gly Glu Lys Pro Tyr Ala Cys Thr Ala Cys
                405                 410                 415     
Cys Lys Thr Phe Ser His Arg Ala Tyr Leu Thr His His Gln Arg Ile
            420                 425                 430         
His Thr Gly Glu Arg Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe
        435                 440                 445             
Arg Gln Arg Ile His Leu Ser Asn His Lys Thr Val His Thr Gly Val
    450                 455                 460                 
Lys Ala Tyr Glu Cys Asn Arg Cys Gly Lys Ala Tyr Arg His Asp Ser
465                 470                 475                 480 
Ser Phe Lys Lys His Gln Arg His His Thr Gly Glu Lys Pro Tyr Glu
                485                 490                 495     
Cys Asn Glu Cys Gly Lys Ala Phe Ser Tyr Asn Ser Ser Leu Ser Arg
            500                 505                 510         
His His Glu Ile His Arg Arg Asn Ala Phe Arg Asn Lys Val
        515                 520                 525     


<210> 5664
<211> 372
<212> PRT
<213> Homo sapiens

<400> 5664
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu
 1               5                  10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu
                325                 330                 335     
His Ser Gly Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser
            340                 345                 350         
Tyr Ser Ala Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr
        355                 360                 365             
Glu Gly Thr Arg
    370         


<210> 5665
<211> 364
<212> PRT
<213> Homo sapiens

<400> 5665
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu
 1               5                  10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Gly Thr Glu His Ala Ser
                325                 330                 335     
Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg Glu Asn
            340                 345                 350         
Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg
        355                 360                 


<210> 5666
<211> 417
<212> PRT
<213> Homo sapiens

<400> 5666
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu
 1               5                  10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu
                325                 330                 335     
His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile
            340                 345                 350         
Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser
        355                 360                 365             
Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser
    370                 375                 380                 
Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala
385                 390                 395                 400 
Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr
                405                 410                 415     
Arg
    


<210> 5667
<211> 392
<212> PRT
<213> Homo sapiens

<400> 5667
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu
 1               5                  10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu
                325                 330                 335     
His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile
            340                 345                 350         
Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser
        355                 360                 365             
Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser
    370                 375                 380                 
Glu His His Gln Ser Cys Arg Asn
385                 390         


<210> 5668
<211> 4834
<212> PRT
<213> Homo sapiens

<400> 5668
Met Pro Ser Glu Ser Phe Cys Leu Ala Ala Gln Ala Arg Leu Asp Ser
 1               5                  10                  15      
Lys Trp Leu Lys Thr Asp Ile Gln Leu Ala Phe Thr Arg Asp Gly Leu
            20                  25                  30          
Cys Gly Leu Trp Asn Glu Met Val Lys Asp Gly Glu Ile Val Tyr Thr
        35                  40                  45              
Gly Thr Glu Ser Thr Gln Asn Gly Glu Leu Pro Pro Arg Lys Asp Asp
    50                  55                  60                  
Ser Val Glu Pro Ser Gly Thr Lys Lys Glu Asp Leu Asn Asp Lys Glu
65                  70                  75                  80  
Lys Lys Asp Glu Glu Glu Thr Pro Ala Pro Ile Tyr Arg Ala Lys Ser
                85                  90                  95      
Ile Leu Asp Ser Trp Val Trp Gly Lys Gln Pro Asp Val Asn Glu Leu
            100                 105                 110         
Lys Glu Cys Leu Ser Val Leu Val Lys Glu Gln Gln Ala Leu Ala Val
        115                 120                 125             
Gln Ser Ala Thr Thr Thr Leu Ser Ala Leu Arg Leu Lys Gln Arg Leu
    130                 135                 140                 
Val Ile Leu Glu Arg Tyr Phe Ile Ala Leu Asn Arg Thr Val Phe Gln
145                 150                 155                 160 
Glu Asn Val Lys Val Lys Trp Lys Ser Ser Gly Ile Ser Leu Pro Pro
                165                 170                 175     
Val Asp Lys Lys Ser Ser Arg Pro Ala Gly Lys Gly Val Glu Gly Leu
            180                 185                 190         
Ala Arg Val Gly Ser Arg Ala Ala Leu Ser Phe Ala Phe Ala Phe Leu
        195                 200                 205             
Arg Arg Ala Trp Arg Ser Gly Glu Asp Ala Asp Leu Cys Ser Glu Leu
    210                 215                 220                 
Leu Gln Glu Ser Leu Asp Ala Leu Arg Ala Leu Pro Glu Ala Ser Leu
225                 230                 235                 240 
Phe Asp Glu Ser Thr Val Ser Ser Val Trp Leu Glu Val Val Glu Arg
                245                 250                 255     
Ala Thr Arg Phe Leu Arg Ser Val Val Thr Gly Asp Val His Gly Thr
            260                 265                 270         
Pro Ala Thr Lys Gly Pro Gly Ser Ile Pro Leu Gln Asp Gln His Leu
        275                 280                 285             
Ala Leu Ala Ile Leu Leu Glu Leu Ala Val Gln Arg Gly Thr Leu Ser
    290                 295                 300                 
Gln Met Leu Ser Ala Ile Leu Leu Leu Leu Gln Leu Trp Asp Ser Gly
305                 310                 315                 320 
Ala Gln Glu Thr Asp Asn Glu Arg Ser Ala Gln Gly Thr Ser Ala Pro
                325                 330                 335     
Leu Leu Pro Leu Leu Gln Arg Phe Gln Ser Ile Ile Cys Arg Lys Asp
            340                 345                 350         
Ala Pro His Ser Glu Gly Asp Met His Leu Leu Ser Gly Pro Leu Ser
        355                 360                 365             
Pro Asn Glu Ser Phe Leu Arg Tyr Leu Thr Leu Pro Gln Asp Asn Glu
    370                 375                 380                 
Leu Ala Ile Asp Leu Arg Gln Thr Ala Val Val Val Met Ala His Leu
385                 390                 395                 400 
Asp Arg Leu Ala Thr Pro Cys Met Pro Pro Leu Cys Ser Ser Pro Thr
                405                 410                 415     
Ser His Lys Gly Ser Leu Gln Glu Val Ile Gly Trp Gly Leu Ile Gly
            420                 425                 430         
Trp Lys Tyr Tyr Ala Asn Val Ile Gly Pro Ile Gln Cys Glu Gly Leu
        435                 440                 445             
Ala Asn Leu Gly Val Thr Gln Ile Ala Cys Ala Glu Lys Arg Phe Leu
    450                 455                 460                 
Ile Leu Ser Arg Asn Gly Arg Val Tyr Thr Gln Ala Tyr Asn Ser Asp
465                 470                 475                 480 
Thr Leu Ala Pro Gln Leu Val Gln Gly Leu Ala Ser Arg Asn Ile Val
                485                 490                 495     
Lys Ile Ala Ala His Ser Asp Gly His His Tyr Leu Ala Leu Ala Ala
            500                 505                 510         
Thr Gly Glu Val Tyr Ser Trp Gly Cys Gly Asp Gly Gly Arg Leu Gly
        515                 520                 525             
His Gly Asp Thr Val Pro Leu Glu Glu Pro Lys Val Ile Ser Ala Phe
    530                 535                 540                 
Ser Gly Lys Gln Ala Gly Lys His Val Val His Ile Ala Cys Gly Ser
545                 550                 555                 560 
Thr Tyr Ser Ala Ala Ile Thr Ala Glu Gly Glu Leu Tyr Thr Trp Gly
                565                 570                 575     
Arg Gly Asn Tyr Gly Arg Leu Gly His Gly Ser Ser Glu Asp Glu Ala
            580                 585                 590         
Ile Pro Met Leu Val Ala Gly Leu Lys Gly Leu Lys Val Ile Asp Val
        595                 600                 605             
Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Ala Val Thr Glu Asn Gly
    610                 615                 620                 
Gln Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly Arg Gly
625                 630                 635                 640 
Gly Ser Asp Gly Cys Lys Thr Pro Lys Leu Ile Glu Lys Leu Gln Asp
                645                 650                 655     
Leu Asp Val Val Lys Val Arg Cys Gly Ser Gln Phe Ser Ile Ala Leu
            660                 665                 670         
Thr Lys Asp Gly Gln Val Tyr Ser Trp Gly Lys Gly Asp Asn Gln Arg
        675                 680                 685             
Leu Gly His Gly Thr Glu Glu His Val Arg Tyr Pro Lys Leu Leu Glu
    690                 695                 700                 
Gly Leu Gln Gly Lys Lys Val Ile Asp Val Ala Ala Gly Ser Thr His
705                 710                 715                 720 
Cys Leu Ala Leu Thr Glu Asp Ser Glu Val His Ser Trp Gly Ser Asn
                725                 730                 735     
Asp Gln Cys Gln His Phe Asp Thr Leu Arg Val Thr Lys Pro Glu Pro
            740                 745                 750         
Ala Ala Leu Pro Gly Leu Asp Thr Lys His Ile Val Gly Ile Ala Cys
        755                 760                 765             
Gly Pro Ala Gln Ser Phe Ala Trp Ser Ser Cys Ser Glu Trp Ser Ile
    770                 775                 780                 
Gly Leu Arg Val Pro Phe Val Val Asp Ile Cys Ser Met Thr Phe Glu
785                 790                 795                 800 
Gln Leu Asp Leu Leu Leu Arg Gln Val Ser Glu Gly Met Asp Gly Ser
                805                 810                 815     
Ala Asp Trp Pro Pro Pro Gln Glu Lys Glu Cys Val Ala Val Ala Thr
            820                 825                 830         
Leu Asn Leu Leu Arg Leu Gln Leu His Ala Ala Ile Ser His Gln Val
        835                 840                 845             
Asp Pro Glu Phe Leu Gly Leu Gly Leu Gly Ser Ile Leu Leu Asn Ser
    850                 855                 860                 
Leu Lys Gln Thr Val Val Thr Leu Ala Ser Ser Ala Gly Val Leu Ser
865                 870                 875                 880 
Thr Val Gln Ser Ala Ala Gln Ala Val Leu Gln Ser Gly Trp Ser Val
                885                 890                 895     
Leu Leu Pro Thr Ala Glu Glu Arg Ala Arg Ala Leu Ser Ala Leu Leu
            900                 905                 910         
Pro Cys Ala Val Ser Gly Asn Glu Val Asn Ile Ser Pro Gly Arg Arg
        915                 920                 925             
Phe Met Ile Asp Leu Leu Val Gly Ser Leu Met Ala Asp Gly Gly Leu
    930                 935                 940                 
Glu Ser Ala Leu His Ala Ala Ile Thr Ala Glu Ile Gln Asp Ile Glu
945                 950                 955                 960 
Ala Lys Lys Glu Ala Gln Lys Glu Lys Glu Ile Asp Glu Gln Glu Ala
                965                 970                 975     
Asn Ala Ser Thr Phe His Arg Ser Arg Thr Pro Leu Asp Lys Asp Leu
            980                 985                 990         
Ile Asn Thr Gly Ile Cys Glu Ser Ser Gly Lys Gln Cys Leu Pro Leu
        995                 1000                1005            
Val Gln Leu Ile Gln Gln Leu Leu Arg Asn Ile Ala Ser Gln Thr Val
    1010                1015                1020                
Ala Arg Leu Lys Asp Val Ala Arg Arg Ile Ser Ser Cys Leu Asp Phe
1025                1030                1035                1040
Glu Gln His Ser Arg Glu Arg Ser Ala Ser Leu Asp Trp Leu Leu Arg
                1045                1050                1055    
Phe Gln Arg Leu Leu Ile Ser Lys Leu Tyr Pro Gly Glu Ser Ile Gly
            1060                1065                1070        
Gln Thr Ser Asp Ile Ser Ser Pro Glu Leu Met Gly Val Gly Ser Leu
        1075                1080                1085            
Leu Lys Lys Tyr Thr Ala Leu Leu Cys Thr His Ile Gly Asp Ile Leu
    1090                1095                1100                
Pro Val Ala Ala Ser Ile Ala Ser Thr Ser Trp Arg His Phe Ala Glu
1105                1110                1115                1120
Val Ala Tyr Ile Val Glu Gly Asp Phe Thr Gly Val Leu Leu Pro Glu
                1125                1130                1135    
Leu Val Val Ser Ile Val Leu Leu Leu Ser Lys Asn Ala Asp Leu Met
            1140                1145                1150        
Gln Glu Ala Gly Ala Val Pro Leu Leu Gly Gly Leu Leu Glu His Leu
        1155                1160                1165            
Asp Arg Phe Asn His Leu Ala Pro Gly Lys Glu Arg Asp Asp His Glu
    1170                1175                1180                
Glu Leu Ala Trp Pro Gly Ile Met Glu Ser Phe Phe Thr Gly Gln Asn
1185                1190                1195                1200
Cys Arg Asn Asn Glu Glu Val Thr Leu Ile Arg Lys Ala Asp Leu Glu
                1205                1210                1215    
Asn His Asn Lys Asp Gly Gly Phe Trp Thr Val Ile Asp Gly Lys Val
            1220                1225                1230        
Tyr Asp Ile Lys Asp Phe Gln Thr Gln Ser Leu Thr Gly Asn Ser Ile
        1235                1240                1245            
Leu Ala Gln Phe Ala Gly Glu Asp Pro Val Val Ala Leu Glu Ala Ala
    1250                1255                1260                
Leu Gln Phe Glu Asp Thr Arg Glu Ser Met His Ala Phe Cys Val Gly
1265                1270                1275                1280
Gln Tyr Leu Glu Pro Asp Gln Glu Ile Val Thr Ile Pro Asp Leu Gly
                1285                1290                1295    
Ser Leu Ser Ser Pro Leu Ile Asp Thr Glu Arg Asn Leu Gly Leu Leu
            1300                1305                1310        
Leu Gly Leu His Ala Ser Tyr Leu Ala Met Ser Thr Pro Leu Ser Pro
        1315                1320                1325            
Val Glu Ile Glu Cys Ala Lys Trp Leu Gln Ser Ser Ile Phe Ser Gly
    1330                1335                1340                
Gly Leu Gln Thr Ser Gln Ile His Tyr Arg Tyr Asn Glu Glu Lys Asp
1345                1350                1355                1360
Glu Asp His Cys Ser Ser Pro Gly Gly Thr Pro Ala Ser Lys Ser Arg
                1365                1370                1375    
Leu Cys Ser His Arg Arg Ala Leu Gly Asp His Ser Gln Ala Phe Leu
            1380                1385                1390        
Gln Ala Ile Ala Asp Asn Asn Ile Gln Asp His Asn Val Lys Asp Phe
        1395                1400                1405            
Leu Cys Gln Ile Glu Arg Tyr Cys Arg Gln Cys His Leu Thr Thr Pro
    1410                1415                1420                
Ile Met Phe Pro Pro Glu His Pro Val Glu Glu Val Gly Arg Leu Leu
1425                1430                1435                1440
Leu Cys Cys Leu Leu Lys His Glu Asp Leu Gly His Val Ala Leu Ser
                1445                1450                1455    
Leu Val His Ala Gly Ala Leu Gly Ile Glu Gln Val Lys His Arg Thr
            1460                1465                1470        
Leu Pro Lys Ser Val Val Asp Val Cys Arg Val Val Tyr Gln Ala Lys
        1475                1480                1485            
Cys Ser Leu Ile Lys Thr His Gln Glu Gln Gly Arg Ser Tyr Lys Glu
    1490                1495                1500                
Val Cys Ala Pro Val Ile Glu Arg Leu Arg Phe Leu Phe Asn Glu Leu
1505                1510                1515                1520
Arg Pro Ala Val Cys Asn Asp Leu Ser Ile Met Ser Lys Phe Lys Leu
                1525                1530                1535    
Leu Ser Ser Leu Pro Arg Trp Arg Arg Ile Ala Gln Lys Ile Ile Arg
            1540                1545                1550        
Glu Arg Arg Lys Lys Arg Val Pro Lys Lys Pro Glu Ser Met Asp Asp
        1555                1560                1565            
Glu Glu Lys Ile Gly Asn Glu Glu Ser Asp Leu Glu Glu Ala Cys Ile
    1570                1575                1580                
Leu Pro His Ser Pro Ile Asn Val Asp Lys Arg Pro Ile Ala Ile Lys
1585                1590                1595                1600
Ser Pro Lys Asp Lys Trp Gln Pro Leu Leu Ser Thr Val Thr Gly Val
                1605                1610                1615    
His Lys Tyr Lys Trp Leu Lys Gln Asn Val Gln Gly Leu Tyr Pro Gln
            1620                1625                1630        
Ser Pro Leu Leu Ser Thr Ile Ala Glu Phe Ala Leu Lys Glu Glu Pro
        1635                1640                1645            
Val Asp Val Glu Lys Met Arg Lys Cys Leu Leu Lys Gln Leu Glu Arg
    1650                1655                1660                
Ala Glu Val Arg Leu Glu Gly Ile Asp Thr Ile Leu Lys Leu Ala Ser
1665                1670                1675                1680
Lys Asn Phe Leu Leu Pro Ser Val Gln Tyr Ala Met Phe Cys Gly Trp
                1685                1690                1695    
Gln Arg Leu Ile Pro Glu Gly Ile Asp Ile Gly Glu Pro Leu Thr Asp
            1700                1705                1710        
Cys Leu Lys Asp Val Asp Leu Ile Pro Pro Phe Asn Arg Met Leu Leu
        1715                1720                1725            
Glu Val Thr Phe Gly Lys Leu Tyr Ala Trp Ala Val Gln Asn Ile Arg
    1730                1735                1740                
Asn Val Leu Met Asp Ala Ser Ala Thr Phe Lys Glu Leu Gly Ile Gln
1745                1750                1755                1760
Pro Val Pro Leu Gln Thr Ile Thr Asn Glu Asn Pro Ser Gly Pro Ser
                1765                1770                1775    
Leu Gly Thr Ile Pro Gln Ala Arg Phe Leu Leu Val Met Leu Ser Met
            1780                1785                1790        
Leu Thr Leu Gln His Gly Ala Asn Asn Leu Asp Leu Leu Leu Asn Ser
        1795                1800                1805            
Gly Met Leu Ala Leu Thr Gln Thr Ala Leu Arg Leu Ile Gly Pro Ser
    1810                1815                1820                
Cys Asp Asn Val Glu Glu Asp Met Asn Ala Ser Ala Gln Gly Ala Ser
1825                1830                1835                1840
Ala Thr Val Leu Glu Glu Thr Arg Lys Glu Thr Ala Pro Val Gln Leu
                1845                1850                1855    
Pro Val Ser Gly Pro Glu Leu Ala Ala Met Met Lys Ile Gly Thr Arg
            1860                1865                1870        
Val Met Arg Gly Val Asp Trp Lys Trp Gly Asp Gln Asp Gly Pro Pro
        1875                1880                1885            
Pro Gly Leu Gly Arg Val Ile Gly Glu Leu Gly Glu Asp Gly Trp Ile
    1890                1895                1900                
Arg Val Gln Trp Asp Thr Gly Ser Thr Asn Ser Tyr Arg Met Gly Lys
1905                1910                1915                1920
Glu Gly Lys Tyr Asp Leu Lys Leu Ala Glu Leu Pro Ala Ala Ala Gln
                1925                1930                1935    
Pro Ser Ala Glu Asp Ser Asp Thr Glu Asp Asp Ser Glu Ala Glu Gln
            1940                1945                1950        
Thr Glu Arg Asn Ile His Pro Thr Ala Met Met Phe Thr Ser Thr Ile
        1955                1960                1965            
Asn Leu Leu Gln Thr Leu Cys Leu Ser Ala Gly Val His Ala Glu Ile
    1970                1975                1980                
Met Gln Ser Glu Ala Thr Lys Thr Leu Cys Gly Leu Leu Arg Met Leu
1985                1990                1995                2000
Val Glu Ser Gly Thr Thr Asp Lys Thr Ser Ser Pro Asn Arg Leu Val
                2005                2010                2015    
Tyr Arg Glu Gln His Arg Ser Trp Cys Thr Leu Gly Phe Val Arg Ser
            2020                2025                2030        
Ile Ala Leu Thr Pro Gln Val Cys Gly Ala Leu Ser Ser Pro Gln Trp
        2035                2040                2045            
Ile Thr Leu Leu Met Lys Val Val Glu Gly His Ala Pro Phe Thr Ala
    2050                2055                2060                
Thr Ser Leu Gln Arg Gln Ile Leu Ala Val His Leu Leu Gln Ala Val
2065                2070                2075                2080
Leu Pro Ser Trp Asp Lys Thr Glu Arg Ala Arg Asp Met Lys Cys Leu
                2085                2090                2095    
Val Glu Lys Leu Phe Asp Phe Leu Gly Ser Leu Leu Thr Thr Cys Ser
            2100                2105                2110        
Ser Asp Val Pro Leu Leu Arg Glu Ser Thr Leu Arg Arg Arg Arg Val
        2115                2120                2125            
Arg Pro Gln Ala Ser Leu Thr Ala Thr His Ser Ser Thr Leu Ala Glu
    2130                2135                2140                
Glu Val Val Ala Leu Leu Arg Thr Leu His Ser Leu Thr Gln Trp Asn
2145                2150                2155                2160
Gly Leu Ile Asn Lys Tyr Ile Asn Ser Gln Leu Arg Ser Ile Thr His
                2165                2170                2175    
Ser Phe Val Gly Arg Pro Ser Glu Gly Ala Gln Leu Glu Asp Tyr Phe
            2180                2185                2190        
Pro Asp Ser Glu Asn Pro Glu Val Gly Gly Leu Met Ala Val Leu Ala
        2195                2200                2205            
Val Ile Gly Gly Ile Asp Gly Arg Leu Arg Leu Gly Gly Gln Val Met
    2210                2215                2220                
His Asp Glu Phe Gly Glu Gly Thr Val Thr Arg Ile Thr Pro Lys Gly
2225                2230                2235                2240
Lys Ile Thr Val Gln Phe Ser Asp Met Arg Thr Cys Arg Val Cys Pro
                2245                2250                2255    
Leu Asn Gln Leu Lys Pro Leu Pro Ala Val Ala Phe Asn Val Asn Asn
            2260                2265                2270        
Leu Pro Phe Thr Glu Pro Met Leu Ser Val Trp Ala Gln Leu Val Asn
        2275                2280                2285            
Leu Ala Gly Ser Lys Leu Glu Lys His Lys Ile Lys Lys Ser Thr Lys
    2290                2295                2300                
Gln Ala Phe Ala Gly Gln Val Asp Leu Asp Leu Leu Arg Cys Gln Gln
2305                2310                2315                2320
Leu Lys Leu Tyr Ile Leu Lys Ala Gly Arg Ala Leu Leu Ser His Gln
                2325                2330                2335    
Asp Lys Leu Arg Gln Ile Leu Ser Gln Pro Ala Val Gln Glu Thr Gly
            2340                2345                2350        
Thr Val His Thr Asp Asp Gly Ala Val Val Ser Pro Asp Leu Gly Asp
        2355                2360                2365            
Met Ser Pro Glu Gly Pro Gln Pro Pro Met Ile Leu Leu Gln Gln Leu
    2370                2375                2380                
Leu Ala Ser Ala Thr Gln Pro Ser Pro Val Lys Ala Ile Phe Asp Lys
2385                2390                2395                2400
Gln Glu Leu Glu Ala Ala Ala Leu Ala Val Cys Gln Cys Leu Ala Val
                2405                2410                2415    
Glu Ser Thr His Pro Ser Ser Pro Gly Phe Glu Asp Cys Ser Ser Ser
            2420                2425                2430        
Glu Ala Thr Thr Pro Val Ala Val Gln His Ile His Pro Ala Arg Val
        2435                2440                2445            
Lys Arg Arg Lys Gln Ser Pro Val Pro Ala Leu Pro Ile Val Val Gln
    2450                2455                2460                
Leu Met Glu Met Gly Phe Ser Arg Arg Asn Ile Glu Phe Ala Leu Lys
2465                2470                2475                2480
Ser Leu Thr Gly Ala Ser Gly Asn Ala Ser Ser Leu Pro Gly Val Glu
                2485                2490                2495    
Ala Leu Val Gly Trp Leu Leu Asp His Ser Asp Ile Gln Val Thr Glu
            2500                2505                2510        
Leu Ser Asp Ala Asp Thr Val Ser Asp Glu Tyr Ser Asp Glu Glu Val
        2515                2520                2525            
Val Glu Asp Val Asp Asp Ala Ala Tyr Ser Met Ser Thr Gly Ala Val
    2530                2535                2540                
Val Thr Glu Ser Gln Thr Tyr Lys Lys Arg Ala Asp Phe Leu Ser Asn
2545                2550                2555                2560
Asp Asp Tyr Ala Val Tyr Val Arg Glu Asn Ile Gln Val Gly Met Met
                2565                2570                2575    
Val Arg Cys Cys Arg Ala Tyr Glu Glu Val Cys Glu Gly Asp Val Gly
            2580                2585                2590        
Lys Val Ile Lys Leu Asp Arg Asp Gly Leu His Asp Leu Asn Val Gln
        2595                2600                2605            
Cys Asp Trp Gln Gln Lys Gly Gly Thr Tyr Trp Val Arg Tyr Ile His
    2610                2615                2620                
Val Glu Leu Ile Gly Tyr Pro Pro Pro Ser Ser Ser Ser His Ile Lys
2625                2630                2635                2640
Ile Gly Asp Lys Val Arg Val Lys Ala Ser Val Thr Thr Pro Lys Tyr
                2645                2650                2655    
Lys Trp Gly Ser Val Thr His Gln Ser Val Gly Val Val Lys Ala Phe
            2660                2665                2670        
Ser Ala Asn Gly Lys Asp Ile Ile Val Asp Phe Pro Gln Gln Ser His
        2675                2680                2685            
Trp Thr Gly Leu Leu Ser Glu Met Glu Leu Val Pro Ser Ile His Pro
    2690                2695                2700                
Gly Val Thr Cys Asp Gly Cys Gln Met Phe Pro Ile Asn Gly Ser Arg
2705                2710                2715                2720
Phe Lys Cys Arg Asn Cys Asp Asp Phe Asp Phe Cys Glu Thr Cys Phe
                2725                2730                2735    
Lys Thr Lys Lys His Asn Thr Arg His Thr Phe Gly Arg Ile Asn Glu
            2740                2745                2750        
Pro Gly Gln Ser Ala Val Phe Cys Gly Arg Ser Gly Lys Gln Leu Lys
        2755                2760                2765            
Arg Cys His Ser Ser Gln Pro Gly Met Leu Leu Asp Ser Trp Ser Arg
    2770                2775                2780                
Met Val Lys Ser Leu Asn Val Ser Ser Ser Val Asn Gln Ala Ser Arg
2785                2790                2795                2800
Leu Ile Asp Gly Ser Glu Pro Cys Trp Gln Ser Ser Gly Ser Gln Gly
                2805                2810                2815    
Lys His Trp Ile Arg Leu Glu Ile Phe Pro Asp Val Leu Val His Arg
            2820                2825                2830        
Leu Lys Met Ile Val Asp Pro Ala Asp Ser Ser Tyr Met Pro Ser Leu
        2835                2840                2845            
Val Val Val Ser Gly Gly Asn Ser Leu Asn Asn Leu Ile Glu Leu Lys
    2850                2855                2860                
Thr Ile Asn Ile Asn Pro Ser Asp Thr Thr Val Pro Leu Leu Asn Asp
2865                2870                2875                2880
Tyr Thr Glu Tyr His Arg Tyr Ile Glu Ile Ala Ile Lys Gln Cys Arg
                2885                2890                2895    
Ser Ser Gly Ile Asp Cys Lys Ile His Gly Leu Ile Leu Leu Gly Arg
            2900                2905                2910        
Ile Arg Ala Glu Glu Glu Asp Leu Ala Ala Val Pro Phe Leu Ala Ser
        2915                2920                2925            
Asp Asn Glu Glu Glu Glu Asp Glu Lys Gly Asn Ser Gly Ser Leu Ile
    2930                2935                2940                
Arg Lys Lys Ala Ala Gly Leu Glu Ser Ala Ala Thr Ile Arg Thr Lys
2945                2950                2955                2960
Val Phe Val Trp Gly Leu Asn Asp Lys Asp Gln Leu Gly Gly Leu Lys
                2965                2970                2975    
Gly Ser Lys Ile Lys Val Pro Ser Phe Ser Glu Thr Leu Ser Ala Leu
            2980                2985                2990        
Asn Val Val Gln Val Ala Gly Gly Ser Lys Ser Leu Phe Ala Val Thr
        2995                3000                3005            
Val Glu Gly Lys Val Tyr Ala Cys Gly Glu Ala Thr Asn Gly Arg Leu
    3010                3015                3020                
Gly Leu Gly Ile Ser Ser Gly Thr Val Pro Ile Pro Arg Gln Ile Thr
3025                3030                3035                3040
Ala Leu Ser Ser Tyr Val Val Lys Lys Val Ala Val His Ser Gly Gly
                3045                3050                3055    
Arg His Ala Thr Ala Leu Thr Val Asp Gly Lys Val Phe Ser Trp Gly
            3060                3065                3070        
Glu Gly Asp Asp Gly Lys Leu Gly His Phe Ser Arg Met Asn Cys Asp
        3075                3080                3085            
Lys Pro Arg Leu Ile Glu Ala Leu Lys Thr Lys Arg Ile Arg Asp Ile
    3090                3095                3100                
Ala Cys Gly Ser Ser His Ser Ala Ala Leu Thr Ser Ser Gly Glu Leu
3105                3110                3115                3120
Tyr Thr Trp Gly Leu Gly Glu Tyr Gly Arg Leu Gly His Gly Asp Asn
                3125                3130                3135    
Thr Thr Gln Leu Lys Pro Lys Met Val Lys Val Leu Leu Gly His Arg
            3140                3145                3150        
Val Ile Gln Val Ala Cys Gly Ser Arg Asp Ala Gln Thr Leu Ala Leu
        3155                3160                3165            
Thr Asp Glu Gly Leu Val Phe Ser Trp Gly Asp Gly Asp Phe Gly Lys
    3170                3175                3180                
Leu Gly Arg Gly Gly Ser Glu Gly Cys Asn Ile Pro Gln Asn Ile Glu
3185                3190                3195                3200
Arg Leu Asn Gly Gln Gly Val Cys Gln Ile Glu Cys Gly Ala Gln Phe
                3205                3210                3215    
Ser Leu Ala Leu Thr Lys Ser Gly Val Val Trp Thr Trp Gly Lys Gly
            3220                3225                3230        
Asp Tyr Phe Arg Leu Gly His Gly Ser Asp Val His Val Arg Lys Pro
        3235                3240                3245            
Gln Val Val Glu Gly Leu Arg Gly Lys Lys Ile Val His Val Ala Val
    3250                3255                3260                
Gly Ala Leu His Cys Leu Ala Val Thr Asp Ser Gly Gln Val Tyr Ala
3265                3270                3275                3280
Trp Gly Asp Asn Asp His Gly Gln Gln Gly Asn Gly Thr Thr Thr Val
                3285                3290                3295    
Asn Arg Lys Pro Thr Leu Val Gln Gly Leu Glu Gly Gln Lys Ile Thr
            3300                3305                3310        
Arg Val Ala Cys Gly Ser Ser His Ser Val Ala Trp Thr Thr Val Asp
        3315                3320                3325            
Val Ala Thr Pro Ser Val His Glu Pro Val Leu Phe Gln Thr Ala Arg
    3330                3335                3340                
Asp Pro Leu Gly Ala Ser Tyr Leu Gly Val Pro Ser Asp Ala Asp Ser
3345                3350                3355                3360
Ser Ala Ala Ser Asn Lys Ile Ser Gly Ala Ser Asn Ser Lys Pro Asn
                3365                3370                3375    
Arg Pro Ser Leu Ala Lys Ile Leu Leu Ser Leu Asp Gly Asn Leu Ala
            3380                3385                3390        
Lys Gln Gln Ala Leu Ser His Ile Leu Thr Ala Leu Gln Ile Met Tyr
        3395                3400                3405            
Ala Arg Asp Ala Val Val Gly Ala Leu Met Pro Ala Ala Met Ile Ala
    3410                3415                3420                
Pro Val Glu Cys Pro Ser Phe Ser Ser Ala Ala Pro Ser Asp Ala Ser
3425                3430                3435                3440
Ala Met Ala Ser Pro Met Asn Gly Glu Glu Cys Met Leu Ala Val Asp
                3445                3450                3455    
Ile Glu Asp Arg Leu Ser Pro Asn Pro Trp Gln Glu Lys Arg Glu Ile
            3460                3465                3470        
Val Ser Ser Glu Asp Ala Val Thr Pro Ser Ala Val Thr Pro Ser Ala
        3475                3480                3485            
Pro Ser Ala Ser Ala Arg Pro Phe Ile Pro Val Thr Asp Asp Leu Gly
    3490                3495                3500                
Ala Ala Ser Ile Ile Ala Glu Thr Met Thr Lys Thr Lys Glu Asp Val
3505                3510                3515                3520
Glu Ser Gln Asn Lys Ala Ala Gly Pro Glu Pro Gln Ala Leu Asp Glu
                3525                3530                3535    
Phe Thr Ser Leu Leu Ile Ala Asp Asp Thr Arg Val Val Val Asp Leu
            3540                3545                3550        
Leu Lys Leu Ser Val Cys Ser Arg Ala Gly Asp Arg Gly Arg Asp Val
        3555                3560                3565            
Leu Ser Ala Val Leu Ser Gly Met Gly Thr Ala Tyr Pro Gln Val Ala
    3570                3575                3580                
Asp Met Leu Leu Glu Leu Cys Val Thr Glu Leu Glu Asp Val Ala Thr
3585                3590                3595                3600
Asp Ser Gln Ser Gly Arg Leu Ser Ser Gln Pro Val Val Val Glu Ser
                3605                3610                3615    
Ser His Pro Tyr Thr Asp Asp Thr Ser Thr Ser Gly Thr Val Lys Ile
            3620                3625                3630        
Pro Gly Ala Glu Gly Leu Arg Val Glu Phe Asp Arg Gln Cys Ser Thr
        3635                3640                3645            
Glu Arg Arg His Asp Pro Leu Thr Val Met Asp Gly Val Asn Arg Ile
    3650                3655                3660                
Val Ser Val Arg Ser Gly Arg Glu Trp Ser Asp Trp Ser Ser Glu Leu
3665                3670                3675                3680
Arg Ile Pro Gly Asp Glu Leu Lys Trp Lys Phe Ile Ser Asp Gly Ser
                3685                3690                3695    
Val Asn Gly Trp Gly Trp Arg Phe Thr Val Tyr Pro Ile Met Pro Ala
            3700                3705                3710        
Ala Gly Pro Lys Glu Leu Leu Ser Asp Arg Cys Val Leu Ser Cys Pro
        3715                3720                3725            
Ser Met Asp Leu Val Thr Cys Leu Leu Asp Phe Arg Leu Asn Leu Ala
    3730                3735                3740                
Ser Asn Arg Ser Ile Val Pro Arg Leu Ala Ala Ser Leu Ala Ala Cys
3745                3750                3755                3760
Ala Gln Leu Ser Ala Leu Ala Ala Ser His Arg Met Trp Ala Leu Gln
                3765                3770                3775    
Arg Leu Arg Lys Leu Leu Thr Thr Glu Phe Gly Gln Ser Ile Asn Ile
            3780                3785                3790        
Asn Arg Leu Leu Gly Glu Asn Asp Gly Glu Thr Arg Ala Leu Ser Phe
        3795                3800                3805            
Thr Gly Ser Ala Leu Ala Ala Leu Val Lys Gly Leu Pro Glu Ala Leu
    3810                3815                3820                
Gln Arg Gln Phe Glu Tyr Glu Asp Pro Ile Val Arg Gly Gly Lys Gln
3825                3830                3835                3840
Leu Leu His Ser Pro Phe Phe Lys Val Leu Val Ala Leu Ala Cys Asp
                3845                3850                3855    
Leu Glu Leu Asp Thr Leu Pro Cys Cys Ala Glu Thr His Lys Trp Ala
            3860                3865                3870        
Trp Phe Arg Arg Tyr Cys Met Ala Ser Arg Val Ala Val Ala Leu Asp
        3875                3880                3885            
Lys Arg Thr Pro Leu Pro Arg Leu Phe Leu Asp Glu Val Ala Lys Lys
    3890                3895                3900                
Ile Arg Glu Leu Met Ala Asp Ser Glu Asn Met Asp Val Leu His Glu
3905                3910                3915                3920
Ser His Asp Ile Phe Lys Arg Glu Gln Asp Glu Gln Leu Val Gln Trp
                3925                3930                3935    
Met Asn Arg Arg Pro Asp Asp Trp Thr Leu Ser Ala Gly Gly Ser Gly
            3940                3945                3950        
Thr Ile Tyr Gly Trp Gly His Asn His Arg Gly Gln Leu Gly Gly Ile
        3955                3960                3965            
Glu Gly Ala Lys Val Lys Val Pro Thr Pro Cys Glu Ala Leu Ala Thr
    3970                3975                3980                
Leu Arg Pro Val Gln Leu Ile Gly Gly Glu Gln Thr Leu Phe Ala Val
3985                3990                3995                4000
Thr Ala Asp Gly Lys Leu Tyr Ala Thr Gly Tyr Gly Ala Gly Gly Arg
                4005                4010                4015    
Leu Gly Ile Gly Gly Thr Glu Ser Val Ser Thr Pro Thr Leu Leu Glu
            4020                4025                4030        
Ser Ile Gln His Val Phe Ile Lys Lys Val Ala Val Asn Ser Gly Gly
        4035                4040                4045            
Lys His Cys Leu Ala Leu Ser Ser Glu Gly Glu Val Tyr Ser Trp Gly
    4050                4055                4060                
Glu Ala Glu Asp Gly Lys Leu Gly His Gly Asn Arg Ser Pro Cys Asp
4065                4070                4075                4080
Arg Pro Arg Val Ile Glu Ser Leu Arg Gly Ile Glu Val Val Asp Val
                4085                4090                4095    
Ala Ala Gly Gly Ala His Ser Ala Cys Val Thr Ala Ala Gly Asp Leu
            4100                4105                4110        
Tyr Thr Trp Gly Lys Gly Arg Tyr Gly Arg Leu Gly His Ser Asp Ser
        4115                4120                4125            
Glu Asp Gln Leu Lys Pro Lys Leu Val Glu Ala Leu Gln Gly His Arg
    4130                4135                4140                
Val Val Asp Ile Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Cys Leu
4145                4150                4155                4160
Thr Asp Asp Asp Thr Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys
                4165                4170                4175    
Leu Gly Arg Gly Gly Ser Asp Gly Cys Lys Val Pro Met Lys Ile Asp
            4180                4185                4190        
Ser Leu Thr Gly Leu Gly Val Val Lys Val Glu Cys Gly Ser Gln Phe
        4195                4200                4205            
Ser Val Ala Leu Thr Lys Ser Gly Ala Val Tyr Thr Trp Gly Lys Gly
    4210                4215                4220                
Asp Tyr His Arg Leu Gly His Gly Ser Asp Asp His Val Arg Arg Pro
4225                4230                4235                4240
Arg Gln Val Gln Gly Leu Gln Gly Lys Lys Val Ile Ala Ile Ala Thr
                4245                4250                4255    
Gly Ser Leu His Cys Val Cys Cys Thr Glu Asp Gly Glu Val Tyr Thr
            4260                4265                4270        
Trp Gly Asp Asn Asp Glu Gly Gln Leu Gly Asp Gly Thr Thr Asn Ala
        4275                4280                4285            
Ile Gln Arg Pro Arg Leu Val Ala Ala Leu Gln Gly Lys Lys Val Asn
    4290                4295                4300                
Arg Val Ala Cys Gly Ser Ala His Thr Leu Ala Trp Ser Thr Ser Lys
4305                4310                4315                4320
Pro Ala Ser Ala Gly Lys Leu Pro Ala Gln Val Pro Met Glu Tyr Asn
                4325                4330                4335    
His Leu Gln Glu Ile Pro Ile Ile Ala Leu Arg Asn Arg Leu Leu Leu
            4340                4345                4350        
Leu His His Leu Ser Glu Leu Phe Cys Pro Cys Ile Pro Met Phe Asp
        4355                4360                4365            
Leu Glu Gly Ser Leu Asp Glu Thr Gly Leu Gly Pro Ser Val Gly Phe
    4370                4375                4380                
Asp Thr Leu Arg Gly Ile Leu Ile Ser Gln Gly Lys Glu Ala Ala Phe
4385                4390                4395                4400
Arg Lys Val Val Gln Ala Thr Met Val Arg Asp Arg Gln His Gly Pro
                4405                4410                4415    
Val Val Glu Leu Asn Arg Ile Gln Val Lys Arg Ser Arg Ser Lys Gly
            4420                4425                4430        
Gly Leu Ala Gly Pro Asp Gly Thr Lys Ser Val Phe Gly Gln Met Cys
        4435                4440                4445            
Ala Lys Met Ser Ser Phe Gly Pro Asp Ser Leu Leu Leu Pro His Arg
    4450                4455                4460                
Val Trp Lys Val Lys Phe Val Gly Glu Ser Val Asp Asp Cys Gly Gly
4465                4470                4475                4480
Gly Tyr Ser Glu Ser Ile Ala Glu Ile Cys Glu Glu Leu Gln Asn Gly
                4485                4490                4495    
Leu Thr Pro Leu Leu Ile Val Thr Pro Asn Gly Arg Asp Glu Ser Gly
            4500                4505                4510        
Ala Asn Arg Asp Cys Tyr Leu Leu Ser Pro Ala Ala Arg Ala Pro Val
        4515                4520                4525            
His Ser Ser Met Phe Arg Phe Leu Gly Val Leu Leu Gly Ile Ala Ile
    4530                4535                4540                
Arg Thr Gly Ser Pro Leu Ser Leu Asn Leu Ala Glu Pro Val Trp Lys
4545                4550                4555                4560
Gln Leu Ala Gly Met Ser Leu Thr Ile Ala Asp Leu Ser Glu Val Asp
                4565                4570                4575    
Lys Asp Phe Ile Pro Gly Leu Met Tyr Ile Arg Asp Asn Glu Ala Thr
            4580                4585                4590        
Ser Glu Glu Phe Glu Ala Met Ser Leu Pro Phe Thr Val Pro Ser Ala
        4595                4600                4605            
Ser Gly Gln Asp Ile Gln Leu Ser Ser Lys His Thr His Ile Thr Leu
    4610                4615                4620                
Asp Asn Arg Ala Glu Tyr Val Arg Leu Ala Ile Asn Tyr Arg Leu His
4625                4630                4635                4640
Glu Phe Asp Glu Gln Val Ala Ala Val Arg Glu Gly Met Ala Arg Val
                4645                4650                4655    
Val Pro Val Pro Leu Leu Ser Leu Phe Thr Gly Tyr Glu Leu Glu Thr
            4660                4665                4670        
Met Val Cys Gly Ser Pro Asp Ile Pro Leu His Leu Leu Lys Ser Val
        4675                4680                4685            
Ala Thr Tyr Lys Gly Ile Glu Pro Ser Ala Ser Leu Ile Gln Trp Phe
    4690                4695                4700                
Trp Glu Val Met Glu Ser Phe Ser Asn Thr Glu Arg Ser Leu Phe Leu
4705                4710                4715                4720
Arg Phe Val Trp Gly Arg Thr Arg Leu Pro Arg Thr Ile Ala Asp Phe
                4725                4730                4735    
Arg Gly Arg Asp Phe Val Ile Gln Val Leu Asp Lys Tyr Asn Pro Pro
            4740                4745                4750        
Asp His Phe Leu Pro Glu Ser Tyr Thr Cys Phe Phe Leu Leu Lys Leu
        4755                4760                4765            
Pro Arg Tyr Ser Cys Lys Gln Val Leu Glu Glu Lys Leu Lys Tyr Ala
    4770                4775                4780                
Ile His Phe Cys Lys Ser Ile Asp Thr Asp Asp Tyr Ala Arg Ile Ala
4785                4790                4795                4800
Leu Thr Gly Glu Pro Ala Ala Asp Asp Ser Ser Asp Asp Ser Asp Asn
                4805                4810                4815    
Glu Asp Val Asp Ser Phe Ala Ser Asp Ser Thr Gln Asp Tyr Leu Thr
            4820                4825                4830        
Gly His
        


<210> 5669
<211> 2162
<212> PRT
<213> Homo sapiens

<400> 5669
Ser Asp Ser Glu Asn Ser Asn Lys Arg Ile Ile Asp Asn Ser Ser Glu
 1               5                  10                  15      
Gln Lys Pro Glu Asn Glu Leu Lys Asn Lys Asn Thr Ser Lys Ile Asn
            20                  25                  30          
Gly Glu Glu Gly Lys Pro His Asn Asn Glu Lys Ala Gly Glu Glu Thr
        35                  40                  45              
Leu Lys Asn Ser Gln Pro Pro Trp Asp Gln Ile Gln Glu Asp Lys Lys
    50                  55                  60                  
His Glu Glu Ala Glu Lys Arg Lys Ser Val Asp Thr Gln Leu Gln Glu
65                  70                  75                  80  
Asp Met Ile Ile His Thr Ser Glu Gln Ser Thr Val Ser Asp His Asn
                85                  90                  95      
Ser Asn Asp Leu Leu Pro Gln Glu Cys Asn Met Asp Lys Thr His Thr
            100                 105                 110         
Met Glu Leu Leu Pro Lys Glu Lys Phe Val Ser Arg Pro Pro Thr Pro
        115                 120                 125             
Lys Cys Val Ile Asp Ile Thr Asn Asp Thr Asn Leu Glu Lys Val Ala
    130                 135                 140                 
Gln Glu Asn Ser Ser Thr Phe Gly Leu Gln Thr Leu Gln Lys Met Asp
145                 150                 155                 160 
Pro Asn Val Ser Asp Ser Lys His Ser Ile Ala Asn Ala Lys Phe Leu
                165                 170                 175     
Glu Thr Ala Lys Lys Asp Ser Asp Gln Ser Trp Val Ser Asp Val Val
            180                 185                 190         
Lys Val Asp Leu Thr Gln Ser Ser Val Thr Asn Ala Ser Ser Gly Asn
        195                 200                 205             
Asp His Leu Asn Met Glu Lys Glu Lys Tyr Val Ser Tyr Ile Ser Pro
    210                 215                 220                 
Leu Ser Ala Val Ser Val Met Glu Asp Lys Leu His Lys Arg Ser Pro
225                 230                 235                 240 
Pro Pro Glu Thr Ile Lys Ser Lys Leu Asn Thr Ser Val Asp Thr His
                245                 250                 255     
Lys Ile Lys Ser Ser Pro Ser Pro Glu Val Val Lys Pro Lys Ile Thr
            260                 265                 270         
His Ser Pro Asp Ser Val Lys Ser Lys Ala Thr Tyr Val Asn Ser Gln
        275                 280                 285             
Ala Thr Gly Glu Arg Arg Leu Ala Asn Lys Ile Glu His Glu Leu Ser
    290                 295                 300                 
Arg Cys Ser Phe His Pro Ile Pro Thr Arg Ser Ser Thr Leu Glu Thr
305                 310                 315                 320 
Thr Lys Ser Pro Leu Ile Ile Asp Lys Asn Glu His Phe Thr Val Tyr
                325                 330                 335     
Arg Asp Pro Ala Leu Ile Gly Ser Glu Thr Gly Ala Asn His Ile Ser
            340                 345                 350         
Pro Phe Leu Ser Gln His Pro Phe Pro Leu His Ser Ser Ser His Arg
        355                 360                 365             
Thr Cys Leu Asn Pro Gly Thr His His Pro Ala Leu Thr Pro Ala Pro
    370                 375                 380                 
His Leu Leu Ala Gly Ser Ser Ser Gln Thr Pro Leu Pro Thr Ile Asn
385                 390                 395                 400 
Thr His Pro Leu Thr Ser Gly Pro His His Ala Val His His Pro His
                405                 410                 415     
Leu Leu Pro Thr Val Leu Pro Gly Val Pro Thr Ala Ser Leu Leu Gly
            420                 425                 430         
Gly His Pro Arg Leu Glu Ser Ala His Ala Ser Ser Leu Ser His Leu
        435                 440                 445             
Ala Leu Ala His Gln Gln Gln Gln Gln Leu Leu Gln His Gln Ser Pro
    450                 455                 460                 
His Leu Leu Gly Gln Ala His Pro Ser Ala Ser Tyr Asn Gln Leu Gly
465                 470                 475                 480 
Leu Tyr Pro Ile Ile Trp Gln Tyr Pro Asn Gly Thr His Ala Tyr Ser
                485                 490                 495     
Gly Leu Gly Leu Pro Ser Ser Lys Trp Val His Pro Glu Asn Ala Val
            500                 505                 510         
Asn Ala Glu Ala Ser Leu Arg Arg Asn Ser Pro Ser Pro Trp Leu His
        515                 520                 525             
Gln Pro Thr Pro Val Thr Ser Ala Asp Gly Ile Gly Leu Leu Ser His
    530                 535                 540                 
Ile Pro Val Arg Pro Ser Ser Ala Glu Pro His Arg Pro Leu Lys Ile
545                 550                 555                 560 
Thr Ala His Ser Ser Pro Pro Leu Thr Lys Thr Leu Val Asp His His
                565                 570                 575     
Lys Glu Glu Leu Glu Arg Lys Ala Phe Met Glu Pro Leu Arg Ser Val
            580                 585                 590         
Ala Ser Thr Ser Ala Lys Asn Asp Leu Asp Leu Asn Arg Ser Gln Thr
        595                 600                 605             
Gly Lys Asp Cys His Leu His Arg His Phe Val Asp Pro Val Leu Asn
    610                 615                 620                 
Gln Leu Gln Arg Pro Pro Gln Glu Thr Gly Glu Arg Leu Asn Lys Tyr
625                 630                 635                 640 
Lys Glu Glu His Arg Arg Ile Leu Gln Glu Ser Ile Asp Val Ala Pro
                645                 650                 655     
Phe Thr Thr Lys Ile Lys Gly Leu Glu Gly Glu Arg Glu Asn Tyr Ser
            660                 665                 670         
Arg Val Ala Ser Ser Ser Ser Ser Pro Lys Ser His Ile Ile Lys Gln
        675                 680                 685             
Asp Met Asp Val Glu Arg Ser Val Ser Asp Leu Tyr Lys Met Lys His
    690                 695                 700                 
Ser Val Pro Gln Ser Leu Pro Gln Ser Asn Tyr Phe Thr Thr Leu Ser
705                 710                 715                 720 
Asn Ser Val Val Asn Glu Pro Pro Arg Ser Tyr Pro Ser Lys Glu Val
                725                 730                 735     
Ser Asn Ile Tyr Gly Asp Lys Gln Ser Asn Ala Leu Ala Ala Ala Ala
            740                 745                 750         
Ala Asn Pro Gln Thr Leu Thr Ser Phe Ile Thr Ser Leu Ser Lys Pro
        755                 760                 765             
Pro Pro Leu Ile Lys His Gln Pro Glu Ser Glu Gly Leu Val Gly Lys
    770                 775                 780                 
Ile Pro Glu His Leu Pro His Gln Ile Ala Ser His Ser Val Thr Thr
785                 790                 795                 800 
Phe Arg Asn Asp Cys Arg Ser Pro Thr His Leu Thr Val Ser Ser Thr
                805                 810                 815     
Asn Thr Leu Arg Ser Met Pro Ala Leu His Arg Ala Pro Val Phe His
            820                 825                 830         
Pro Pro Ile His His Ser Leu Glu Arg Lys Glu Gly Ser Tyr Ser Ser
        835                 840                 845             
Leu Ser Pro Pro Thr Leu Thr Pro Val Met Pro Val Asn Ala Gly Gly
    850                 855                 860                 
Lys Val Gln Glu Ser Gln Lys Pro Pro Thr Leu Ile Pro Glu Pro Lys
865                 870                 875                 880 
Asp Ser Gln Ala Asn Phe Lys Ser Ser Ser Glu Gln Ser Leu Thr Glu
                885                 890                 895     
Met Trp Arg Pro Asn Asn Asn Leu Ser Lys Glu Lys Thr Glu Trp His
            900                 905                 910         
Val Glu Lys Ser Ser Gly Lys Leu Gln Ala Ala Met Ala Ser Val Ile
        915                 920                 925             
Val Arg Pro Ser Ser Ser Thr Lys Thr Asp Ser Met Pro Ala Met Gln
    930                 935                 940                 
Leu Ala Ser Lys Asp Arg Val Ser Glu Arg Ser Ser Ala Gly Ala His
945                 950                 955                 960 
Lys Thr Asp Cys Leu Lys Leu Ala Glu Ala Gly Glu Thr Gly Arg Ile
                965                 970                 975     
Ile Leu Pro Asn Val Asn Ser Asp Ser Val His Thr Lys Ser Glu Lys
            980                 985                 990         
Asn Phe Gln Ala Val Ser Gln Gly Ser Val Pro Ser Ser Val Met Ser
        995                 1000                1005            
Ala Val Asn Thr Met Cys Asn Thr Lys Thr Asp Val Ile Thr Ser Ala
    1010                1015                1020                
Ala Asp Thr Thr Ser Val Ser Ser Trp Gly Gly Ser Glu Val Ile Ser
1025                1030                1035                1040
Ser Leu Ser Asn Thr Ile Leu Ala Ser Thr Ser Ser Glu Cys Val Ser
                1045                1050                1055    
Ser Lys Ser Val Ser Gln Pro Val Ala Gln Lys Gln Glu Cys Lys Val
            1060                1065                1070        
Ser Thr Thr Ala Pro Val Thr Leu Ala Ser Ser Lys Thr Gly Ser Val
        1075                1080                1085            
Val Gln Pro Ser Ser Gly Phe Ser Gly Thr Thr Asp Phe Ile His Leu
    1090                1095                1100                
Lys Lys His Lys Ala Ala Leu Ala Ala Ala Gln Tyr Lys Ser Ser Asn
1105                1110                1115                1120
Ala Ser Glu Thr Glu Pro Asn Ala Ile Lys Asn Gln Thr Leu Ser Ala
                1125                1130                1135    
Ser Leu Pro Leu Asp Ser Thr Val Ile Cys Ser Thr Ile Asn Lys Ala
            1140                1145                1150        
Asn Ser Val Gly Asn Gly Gln Ala Ser Gln Thr Ser Gln Pro Asn Tyr
        1155                1160                1165            
His Thr Lys Leu Lys Lys Ala Trp Leu Thr Arg His Ser Glu Glu Asp
    1170                1175                1180                
Lys Asn Thr Asn Lys Met Glu Asn Ser Gly Asn Ser Val Ser Glu Ile
1185                1190                1195                1200
Ile Lys Pro Cys Ser Val Asn Leu Ile Ala Ser Thr Ser Ser Asp Ile
                1205                1210                1215    
Gln Asn Ser Val Asp Ser Lys Ile Ile Val Asp Lys Tyr Val Lys Asp
            1220                1225                1230        
Asp Lys Val Asn Arg Arg Lys Ala Lys Arg Thr Tyr Glu Ser Gly Ser
        1235                1240                1245            
Glu Ser Gly Asp Ser Asp Glu Ser Glu Ser Lys Ser Glu Gln Arg Thr
    1250                1255                1260                
Lys Arg Gln Pro Lys Pro Thr Tyr Lys Lys Lys Gln Asn Asp Leu Gln
1265                1270                1275                1280
Lys Arg Lys Gly Glu Ile Glu Glu Asp Leu Lys Pro Asn Gly Val Leu
                1285                1290                1295    
Ser Arg Ser Ala Lys Glu Arg Ser Lys Leu Lys Leu Gln Ser Asn Ser
            1300                1305                1310        
Asn Thr Gly Ile Pro Arg Ser Val Leu Lys Asp Trp Arg Lys Val Lys
        1315                1320                1325            
Lys Leu Lys Gln Thr Gly Glu Ser Phe Leu Gln Asp Asp Ser Cys Cys
    1330                1335                1340                
Glu Ile Gly Pro Asn Leu Gln Lys Cys Arg Glu Cys Arg Leu Ile Arg
1345                1350                1355                1360
Ser Lys Lys Gly Glu Glu Pro Ala His Ser Pro Val Phe Cys Arg Phe
                1365                1370                1375    
Tyr Tyr Phe Arg Arg Leu Ser Phe Ser Lys Asn Gly Val Val Arg Ile
            1380                1385                1390        
Asp Gly Phe Ser Ser Pro Asp Gln Tyr Asp Asp Glu Ala Met Ser Leu
        1395                1400                1405            
Trp Thr His Glu Asn Phe Glu Asp Asp Glu Leu Asp Ile Glu Thr Ser
    1410                1415                1420                
Lys Tyr Ile Leu Asp Ile Ile Gly Asp Lys Phe Cys Gln Leu Val Thr
1425                1430                1435                1440
Ser Glu Lys Thr Ala Leu Ser Trp Val Lys Lys Asp Ala Lys Ile Ala
                1445                1450                1455    
Trp Lys Arg Ala Val Arg Gly Val Arg Glu Met Cys Asp Ala Cys Glu
            1460                1465                1470        
Ala Thr Leu Phe Asn Ile His Trp Val Cys Gln Lys Cys Gly Phe Val
        1475                1480                1485            
Val Cys Leu Asp Cys Tyr Lys Ala Lys Glu Arg Lys Ser Ser Arg Asp
    1490                1495                1500                
Lys Glu Leu Tyr Ala Trp Met Lys Cys Val Lys Gly Gln Pro His Asp
1505                1510                1515                1520
His Lys His Leu Met Pro Thr Gln Ile Ile Pro Gly Ser Val Leu Thr
                1525                1530                1535    
Asp Leu Leu Asp Ala Met His Thr Leu Arg Glu Lys Tyr Gly Ile Lys
            1540                1545                1550        
Ser His Cys His Cys Thr Asn Lys Gln Asn Leu Gln Val Gly Asn Phe
        1555                1560                1565            
Pro Thr Met Asn Gly Val Ser Gln Val Leu Gln Asn Val Leu Asn His
    1570                1575                1580                
Ser Asn Lys Ile Ser Leu Cys Met Pro Glu Ser Gln Gln Gln Asn Thr
1585                1590                1595                1600
Pro Pro Lys Ser Glu Lys Asn Gly Gly Ser Ser Pro Glu Ser Asp Val
                1605                1610                1615    
Gly Thr Asp Asn Lys Leu Thr Pro Pro Glu Ser Gln Ser Pro Leu His
            1620                1625                1630        
Trp Leu Ala Asp Leu Ala Glu Gln Lys Ala Arg Glu Glu Lys Lys Glu
        1635                1640                1645            
Asn Lys Glu Leu Thr Leu Glu Asn Gln Ile Lys Glu Glu Arg Glu Gln
    1650                1655                1660                
Asp Asn Ser Glu Ser Pro Asn Gly Arg Thr Ser Pro Leu Val Ser Gln
1665                1670                1675                1680
Asn Asn Glu Gln Gly Ser Thr Leu Arg Asp Leu Leu Thr Thr Thr Ala
                1685                1690                1695    
Gly Lys Leu Arg Val Gly Ser Thr Asp Ala Gly Ile Ala Phe Ala Pro
            1700                1705                1710        
Val Tyr Ser Met Gly Ala Pro Ser Ser Lys Ser Gly Arg Thr Met Pro
        1715                1720                1725            
Asn Ile Leu Asp Asp Ile Ile Ala Ser Val Val Glu Asn Lys Ile Pro
    1730                1735                1740                
Pro Ser Lys Thr Ser Lys Ile Asn Val Lys Pro Glu Leu Lys Glu Glu
1745                1750                1755                1760
Pro Glu Glu Ser Ile Ile Ser Ala Val Asp Glu Asn Asn Lys Leu Tyr
                1765                1770                1775    
Ser Asp Ile Pro His Ser Trp Ile Cys Glu Lys His Ile Leu Trp Leu
            1780                1785                1790        
Lys Asp Tyr Lys Asn Ser Ser Asn Trp Lys Leu Phe Lys Glu Cys Trp
        1795                1800                1805            
Lys Gln Gly Gln Pro Ala Val Val Ser Gly Val His Lys Lys Met Asn
    1810                1815                1820                
Ile Ser Leu Trp Lys Ala Glu Ser Ile Ser Leu Asp Phe Gly Asp His
1825                1830                1835                1840
Gln Ala Asp Leu Leu Asn Cys Lys Asp Ser Ile Ile Ser Asn Ala Asn
                1845                1850                1855    
Val Lys Glu Phe Trp Asp Gly Phe Glu Glu Val Ser Lys Arg Gln Lys
            1860                1865                1870        
Asn Lys Ser Gly Glu Thr Val Val Leu Lys Leu Lys Asp Trp Pro Ser
        1875                1880                1885            
Gly Glu Asp Phe Lys Thr Met Met Pro Ala Arg Tyr Glu Asp Leu Leu
    1890                1895                1900                
Lys Ser Leu Pro Leu Pro Glu Tyr Cys Asn Pro Glu Gly Lys Phe Asn
1905                1910                1915                1920
Leu Ala Ser His Leu Pro Gly Phe Phe Val Arg Pro Asp Leu Gly Pro
                1925                1930                1935    
Arg Leu Cys Ser Ala Tyr Gly Val Val Ala Ala Lys Asp His Asp Ile
            1940                1945                1950        
Gly Thr Thr Asn Leu His Ile Glu Val Ser Asp Val Val Asn Ile Leu
        1955                1960                1965            
Val Tyr Val Gly Ile Ala Lys Gly Asn Gly Ile Leu Ser Lys Ala Gly
    1970                1975                1980                
Ile Leu Lys Lys Phe Glu Glu Glu Asp Leu Asp Asp Ile Leu Arg Lys
1985                1990                1995                2000
Arg Leu Lys Asp Ser Ser Glu Ile Pro Gly Ala Leu Trp His Ile Tyr
                2005                2010                2015    
Ala Gly Lys Asp Val Asp Lys Ile Arg Glu Phe Leu Gln Lys Ile Ser
            2020                2025                2030        
Lys Glu Gln Gly Leu Glu Val Leu Pro Glu His Asp Pro Ile Arg Asp
        2035                2040                2045            
Gln Ser Trp Tyr Val Asn Lys Lys Leu Arg Gln Arg Leu Leu Glu Glu
    2050                2055                2060                
Tyr Gly Val Arg Thr Cys Thr Leu Ile Gln Phe Leu Gly Asp Ala Ile
2065                2070                2075                2080
Val Leu Pro Ala Gly Ala Leu His Gln Val Gln Asn Phe His Ser Cys
                2085                2090                2095    
Ile Gln Val Thr Glu Asp Phe Val Ser Pro Glu His Leu Val Glu Ser
            2100                2105                2110        
Phe His Leu Thr Gln Glu Leu Arg Leu Leu Lys Glu Glu Ile Asn Tyr
        2115                2120                2125            
Asp Asp Lys Leu Gln Val Lys Asn Ile Leu Tyr His Ala Val Lys Glu
    2130                2135                2140                
Met Val Arg Ala Leu Lys Ile His Glu Asp Glu Val Asp Asp Met Glu
2145                2150                2155                2160
Glu Asn
        


<210> 5670
<211> 2210
<212> PRT
<213> Homo sapiens

<400> 5670
Met Ile Val Met Asn Asp Gln Val Leu Glu Pro Gln Asn Val Asp Pro
 1               5                  10                  15      
Ser Met Val Gln Met Thr Phe Leu Asp Asp Val Val His Ser Leu Leu
            20                  25                  30          
Lys Gly Glu Asn Ile Gly Ile Thr Ser Arg Arg Arg Ser Arg Ala Asn
        35                  40                  45              
Gln Asn Val Asn Ala Val His Ser His Tyr Thr Arg Ala Gln Ala Asn
    50                  55                  60                  
Ser Pro Arg Pro Ala Met Asn Ser Gln Ala Ala Val Pro Lys Gln Asn
65                  70                  75                  80  
Thr His Gln Gln Gln Gln Gln Arg Ser Ile Arg Pro Asn Lys Arg Lys
                85                  90                  95      
Gly Ser Asp Ser Ser Ile Pro Asp Glu Glu Lys Met Lys Glu Glu Lys
            100                 105                 110         
Tyr Asp Tyr Ile Ser Arg Gly Glu Asn Pro Lys Gly Lys Asn Lys His
        115                 120                 125             
Leu Met Asn Lys Arg Arg Lys Pro Glu Glu Asp Glu Lys Lys Leu Asn
    130                 135                 140                 
Met Lys Arg Leu Arg Thr Asp Asn Val Ser Asp Phe Ser Glu Ser Ser
145                 150                 155                 160 
Asp Ser Glu Asn Ser Asn Lys Arg Ile Ile Asp Asn Ser Ser Glu Gln
                165                 170                 175     
Lys Pro Glu Asn Glu Leu Lys Asn Lys Asn Thr Ser Lys Ile Asn Gly
            180                 185                 190         
Glu Glu Gly Lys Pro His Asn Asn Glu Lys Ala Gly Glu Glu Thr Leu
        195                 200                 205             
Lys Asn Ser Gln Pro Pro Trp Asp Gln Ile Gln Glu Asp Lys Lys His
    210                 215                 220                 
Glu Glu Ala Glu Lys Arg Lys Ser Val Asp Thr Gln Leu Gln Glu Asp
225                 230                 235                 240 
Met Ile Ile His Ser Ser Glu Gln Ser Thr Val Ser Asp His Asn Ser
                245                 250                 255     
Asn Asp Leu Leu Pro Gln Glu Cys Asn Met Asp Lys Ala His Thr Met
            260                 265                 270         
Glu Leu Leu Pro Lys Glu Lys Phe Val Ser Arg Pro Pro Thr Pro Lys
        275                 280                 285             
Cys Val Ile Asp Ile Thr Asn Asp Thr Asn Leu Glu Lys Val Ala Gln
    290                 295                 300                 
Glu Asn Ser Ser Thr Phe Gly Leu Gln Thr Leu Gln Lys Met Asp Pro
305                 310                 315                 320 
Asn Val Ser Asp Ser Lys His Ser Ile Ala Asn Ala Lys Phe Leu Glu
                325                 330                 335     
Thr Ala Lys Lys Asp Ser Asp Gln Ser Trp Val Ser Asp Val Val Lys
            340                 345                 350         
Val Asp Leu Thr Gln Ser Ser Val Thr Asn Ala Ser Ser Gly Asn Asp
        355                 360                 365             
His Leu Asn Met Glu Lys Glu Lys Tyr Val Ser Tyr Ile Ser Pro Leu
    370                 375                 380                 
Ser Ala Val Ser Val Met Glu Asp Lys Leu His Lys Arg Ser Pro Pro
385                 390                 395                 400 
Pro Glu Thr Ile Lys Ser Lys Leu Asn Thr Ser Val Asp Thr His Lys
                405                 410                 415     
Ile Lys Ser Ser Pro Ser Pro Glu Val Val Lys Pro Lys Ile Thr His
            420                 425                 430         
Ser Pro Asp Ser Val Lys Ser Lys Ala Thr Tyr Val Asn Ser Gln Ala
        435                 440                 445             
Thr Gly Glu Arg Arg Leu Ala Asn Lys Ile Glu His Glu Leu Ser Arg
    450                 455                 460                 
Cys Ser Phe His Pro Ile Pro Thr Arg Ser Ser Thr Leu Glu Thr Thr
465                 470                 475                 480 
Lys Ser Pro Leu Ile Ile Asp Lys Asn Glu His Phe Thr Val Tyr Arg
                485                 490                 495     
Asp Pro Ala Leu Ile Gly Ser Glu Thr Gly Ala Asn His Ile Ser Pro
            500                 505                 510         
Phe Leu Ser Gln His Pro Phe Pro Leu His Ser Ser Ser His Arg Thr
        515                 520                 525             
Cys Leu Asn Pro Gly Thr His His Pro Ala Leu Thr Pro Ala Pro His
    530                 535                 540                 
Leu Leu Ala Gly Ser Ser Ser Gln Thr Pro Leu Pro Thr Ile Asn Ala
545                 550                 555                 560 
His Pro Leu Pro Ser Gly Pro His His Ala Val His His Pro His Leu
                565                 570                 575     
Leu Pro Thr Val Leu Pro Gly Val Pro Thr Ala Ser Leu Leu Gly Gly
            580                 585                 590         
His Pro Arg Leu Glu Ser Ala His Ala Ser Ser Leu Ser His Leu Ala
        595                 600                 605             
Leu Ala His Gln Gln Gln Gln Gln Leu Leu Gln His Gln Ser Pro His
    610                 615                 620                 
Leu Leu Gly Gln Ala His Pro Ser Ala Ser Tyr Asn Gln Leu Gly Leu
625                 630                 635                 640 
Tyr Pro Ile Ile Trp Gln Tyr Pro Asn Gly Thr His Ala Tyr Ser Gly
                645                 650                 655     
Leu Gly Leu Pro Ser Ser Lys Trp Val His Pro Glu Asn Ala Val Asn
            660                 665                 670         
Ala Glu Ala Ser Leu Arg Arg Asn Ser Pro Ser Pro Trp Leu His Gln
        675                 680                 685             
Pro Thr Pro Val Thr Ser Ala Asp Gly Ile Gly Leu Leu Ser His Ile
    690                 695                 700                 
Pro Val Arg Pro Ser Ser Ala Glu Pro His Arg Pro Leu Lys Ile Thr
705                 710                 715                 720 
Ala His Ser Ser Pro Pro Leu Thr Lys Thr Leu Val Asp His His Lys
                725                 730                 735     
Glu Glu Leu Glu Arg Lys Ala Phe Met Glu Pro Leu Arg Ser Val Ala
            740                 745                 750         
Ser Thr Ser Ala Lys Asn Asp Leu Asp Leu Asn Arg Ser Gln Thr Gly
        755                 760                 765             
Lys Asp Cys His Leu His Arg His Phe Val Asp Pro Val Leu Asn Gln
    770                 775                 780                 
Leu Gln Arg Pro Pro Gln Glu Thr Gly Glu Arg Leu Asn Lys Tyr Lys
785                 790                 795                 800 
Glu Glu His Arg Arg Ile Leu Gln Glu Ser Ile Asp Val Ala Pro Phe
                805                 810                 815     
Thr Thr Lys Ile Lys Gly Leu Glu Gly Glu Arg Glu Asn Tyr Ser Arg
            820                 825                 830         
Val Ala Ser Ser Ser Ser Ser Pro Lys Ser His Ile Ile Lys Gln Asp
        835                 840                 845             
Met Asp Val Glu Arg Ser Val Ser Asp Leu Tyr Lys Met Lys His Ser
    850                 855                 860                 
Val Pro Gln Ser Leu Pro Gln Ser Asn Tyr Phe Thr Thr Leu Ser Asn
865                 870                 875                 880 
Ser Val Val Asn Glu Pro Pro Arg Ser Tyr Pro Ser Lys Glu Val Ser
                885                 890                 895     
Asn Ile Tyr Gly Asp Lys Gln Ser Asn Ala Leu Ala Ala Ala Ala Ala
            900                 905                 910         
Asn Pro Gln Thr Leu Thr Ser Phe Ile Thr Ser Leu Ser Lys Pro Pro
        915                 920                 925             
Pro Leu Ile Lys His Gln Pro Glu Ser Glu Gly Leu Val Gly Lys Ile
    930                 935                 940                 
Pro Glu His Leu Pro His Gln Ile Ala Ser His Ser Val Thr Thr Phe
945                 950                 955                 960 
Arg Asn Asp Cys Arg Ser Pro Thr His Leu Thr Val Ser Ser Thr Asn
                965                 970                 975     
Thr Leu Arg Ser Met Pro Ala Leu His Arg Ala Pro Val Phe His Pro
            980                 985                 990         
Pro Ile His His Ser Leu Glu Arg Lys Glu Gly Ser Tyr Ser Ser Leu
        995                 1000                1005            
Ser Pro Pro Thr Leu Thr Pro Val Met Pro Val Asn Ala Gly Gly Lys
    1010                1015                1020                
Val Gln Glu Ser Gln Lys Pro Pro Thr Leu Ile Pro Glu Pro Lys Asp
1025                1030                1035                1040
Ser Gln Ala Asn Phe Lys Ser Ser Ser Glu Gln Ser Leu Thr Glu Met
                1045                1050                1055    
Trp Arg Pro Asn Asn Asn Leu Ser Lys Glu Lys Thr Glu Trp His Val
            1060                1065                1070        
Glu Lys Ser Ser Gly Lys Leu Gln Ala Ala Met Ala Ser Val Ile Val
        1075                1080                1085            
Arg Pro Ser Ser Ser Thr Lys Thr Asp Ser Met Pro Ala Met Gln Leu
    1090                1095                1100                
Ala Ser Lys Asp Arg Val Ser Glu Arg Ser Ser Ala Gly Ala His Lys
1105                1110                1115                1120
Thr Asp Cys Leu Lys Leu Ala Glu Ala Gly Glu Thr Gly Arg Ile Ile
                1125                1130                1135    
Leu Pro Asn Val Asn Ser Asp Ser Val His Thr Lys Ser Glu Lys Asn
            1140                1145                1150        
Phe Gln Ala Val Ser Gln Gly Ser Val Pro Ser Ser Val Met Ser Ala
        1155                1160                1165            
Val Asn Thr Met Cys Asn Thr Lys Thr Asp Val Ile Thr Ser Ala Ala
    1170                1175                1180                
Asp Thr Thr Ser Val Ser Ser Trp Gly Gly Ser Glu Val Ile Ser Ser
1185                1190                1195                1200
Leu Ser Asn Thr Ile Leu Ala Ser Thr Ser Ser Glu Cys Val Ser Ser
                1205                1210                1215    
Lys Ser Val Ser Gln Pro Val Ala Gln Lys Gln Glu Cys Lys Val Ser
            1220                1225                1230        
Thr Thr Ala Pro Val Thr Leu Ala Ser Ser Lys Thr Gly Ser Val Val
        1235                1240                1245            
Gln Pro Ser Ser Gly Phe Ser Gly Thr Thr Asp Phe Ile His Leu Lys
    1250                1255                1260                
Lys His Lys Ala Ala Leu Ala Ala Ala Gln Tyr Lys Ser Ser Asn Ala
1265                1270                1275                1280
Ser Glu Thr Glu Pro Asn Ala Ile Lys Asn Gln Thr Leu Ser Ala Ser
                1285                1290                1295    
Leu Pro Leu Asp Ser Thr Val Ile Cys Ser Thr Ile Asn Lys Ala Asn
            1300                1305                1310        
Ser Val Gly Asn Gly Gln Ala Ser Gln Thr Ser Gln Pro Asn Tyr His
        1315                1320                1325            
Thr Lys Leu Lys Lys Ala Trp Leu Thr Arg His Ser Glu Glu Asp Lys
    1330                1335                1340                
Asn Thr Asn Lys Met Glu Asn Ser Gly Asn Ser Val Ser Glu Ile Ile
1345                1350                1355                1360
Lys Pro Cys Ser Val Asn Leu Ile Ala Ser Thr Ser Ser Asp Ile Gln
                1365                1370                1375    
Asn Ser Val Asp Ser Lys Ile Ile Val Asp Lys Tyr Val Lys Asp Asp
            1380                1385                1390        
Lys Val Asn Arg Arg Lys Ala Lys Arg Thr Tyr Glu Ser Gly Ser Glu
        1395                1400                1405            
Ser Gly Asp Ser Asp Glu Ser Glu Ser Lys Ser Glu Gln Arg Thr Lys
    1410                1415                1420                
Arg Gln Pro Lys Pro Thr Tyr Lys Lys Lys Gln Asn Asp Leu Gln Lys
1425                1430                1435                1440
Arg Lys Gly Glu Ile Glu Glu Asp Leu Lys Pro Asn Gly Val Leu Ser
                1445                1450                1455    
Arg Ser Ala Lys Glu Arg Ser Lys Leu Lys Leu Gln Ser Asn Ser Asn
            1460                1465                1470        
Ser Cys His Leu Val Asn Gly Val Val Arg Ile Asp Gly Phe Ser Ser
        1475                1480                1485            
Pro Asp Gln Tyr Asp Asp Glu Ala Met Ser Leu Trp Thr His Glu Asn
    1490                1495                1500                
Phe Glu Asp Asp Glu Leu Asp Ile Glu Thr Ser Lys Tyr Ile Leu Asp
1505                1510                1515                1520
Ile Ile Gly Asp Lys Phe Cys Gln Leu Val Thr Ser Glu Lys Thr Ala
                1525                1530                1535    
Leu Pro Arg Val Lys Lys Asp Ala Lys Ile Ala Trp Lys Arg Ala Val
            1540                1545                1550        
Arg Gly Val Arg Glu Met Cys Asp Ala Cys Glu Ala Thr Leu Phe Asn
        1555                1560                1565            
Ile His Trp Val Cys Gln Lys Cys Gly Phe Val Val Cys Leu Asp Cys
    1570                1575                1580                
Tyr Lys Ala Lys Glu Arg Lys Ser Ser Arg Asp Lys Glu Leu Tyr Ala
1585                1590                1595                1600
Trp Met Lys Cys Val Lys Gly Gln Pro His Asp His Lys His Leu Met
                1605                1610                1615    
Pro Thr Gln Ile Ile Pro Gly Ser Val Leu Thr Asp Leu Leu Asp Ala
            1620                1625                1630        
Met His Thr Leu Arg Glu Lys Tyr Gly Ile Lys Ser His Cys His Cys
        1635                1640                1645            
Thr Asn Lys Gln Asn Leu Gln Val Gly Asn Phe Pro Thr Met Asn Gly
    1650                1655                1660                
Val Ser Gln Ser Gln Gln Gln Asn Thr Pro Pro Lys Ser Glu Lys Asn
1665                1670                1675                1680
Gly Gly Ser Ser Pro Glu Ser Asp Val Gly Thr Asp Asn Lys Leu Thr
                1685                1690                1695    
Pro Pro Glu Ser Gln Ser Pro Leu His Trp Leu Ala Asp Leu Ala Glu
            1700                1705                1710        
Gln Lys Ala Arg Glu Glu Lys Lys Glu Asn Lys Glu Leu Thr Leu Glu
        1715                1720                1725            
Asn Gln Ile Lys Glu Glu Arg Glu Gln Asp Asn Ser Glu Ser Pro Asn
    1730                1735                1740                
Gly Arg Thr Ser Pro Leu Val Ser Gln Asn Asn Glu Gln Gly Ser Thr
1745                1750                1755                1760
Leu Arg Asp Leu Leu Thr Thr Thr Ala Gly Lys Leu Arg Val Gly Ser
                1765                1770                1775    
Thr Asp Ala Gly Ile Ala Phe Ala Pro Val Tyr Ser Met Gly Ala Pro
            1780                1785                1790        
Ser Ser Lys Ser Gly Arg Thr Met Pro Asn Ile Leu Asp Asp Ile Ile
        1795                1800                1805            
Ala Ser Val Val Glu Asn Lys Ile Pro Pro Ser Lys Thr Ser Lys Ile
    1810                1815                1820                
Asn Val Lys Pro Glu Leu Lys Glu Glu Pro Glu Glu Ser Ile Ile Ser
1825                1830                1835                1840
Ala Val Asp Glu Asn Asn Lys Leu Tyr Ser Asp Ile Pro His Ser Trp
                1845                1850                1855    
Ile Cys Glu Lys His Ile Leu Trp Leu Lys Asp Tyr Lys Asn Ser Ser
            1860                1865                1870        
Asn Trp Lys Leu Phe Lys Glu Cys Trp Lys Gln Gly Gln Pro Ala Val
        1875                1880                1885            
Val Ser Gly Val His Lys Lys Met Asn Ile Ser Leu Trp Lys Ala Glu
    1890                1895                1900                
Ser Ile Ser Leu Asp Phe Gly Asp His Gln Ala Asp Leu Leu Asn Cys
1905                1910                1915                1920
Lys Asp Ser Ile Ile Ser Asn Ala Asn Val Lys Glu Phe Trp Asp Gly
                1925                1930                1935    
Phe Glu Glu Val Ser Lys Arg Gln Lys Asn Lys Ser Gly Glu Thr Val
            1940                1945                1950        
Val Leu Lys Leu Lys Asp Trp Pro Ser Gly Glu Asp Phe Lys Thr Met
        1955                1960                1965            
Met Pro Ala Arg Tyr Glu Asp Leu Leu Lys Ser Leu Pro Leu Pro Glu
    1970                1975                1980                
Tyr Cys Asn Pro Glu Gly Lys Phe Asn Leu Ala Ser His Leu Pro Gly
1985                1990                1995                2000
Phe Phe Val Arg Pro Asp Leu Gly Pro Arg Leu Cys Ser Ala Tyr Gly
                2005                2010                2015    
Val Val Ala Ala Lys Asp His Asp Ile Gly Thr Thr Asn Leu His Ile
            2020                2025                2030        
Glu Val Ser Asp Val Val Asn Ile Leu Val Tyr Val Gly Ile Ala Lys
        2035                2040                2045            
Gly Asn Gly Ile Leu Ser Lys Ala Gly Ile Leu Lys Lys Phe Glu Glu
    2050                2055                2060                
Glu Asp Leu Asp Asp Ile Leu Arg Lys Arg Leu Lys Asp Ser Ser Glu
2065                2070                2075                2080
Ile Pro Gly Ala Leu Trp His Ile Tyr Ala Gly Lys Asp Val Asp Lys
                2085                2090                2095    
Ile Arg Glu Phe Leu Gln Lys Ile Ser Lys Glu Gln Gly Leu Glu Val
            2100                2105                2110        
Leu Pro Glu His Asp Pro Ile Arg Asp Gln Ser Trp Tyr Val Asn Lys
        2115                2120                2125            
Lys Leu Arg Gln Arg Leu Leu Glu Glu Tyr Gly Val Arg Thr Cys Thr
    2130                2135                2140                
Leu Ile Gln Phe Leu Gly Asp Ala Ile Val Leu Pro Ala Gly Ala Leu
2145                2150                2155                2160
His Gln Val Gln Asn Phe His Ser Cys Ile Gln Val Thr Glu Asp Phe
                2165                2170                2175    
Val Ser Pro Glu His Leu Val Glu Ser Phe His Leu Thr Gln Glu Leu
            2180                2185                2190        
Arg Leu Leu Lys Glu Glu Ile Asn Tyr Asp Asp Lys Leu Gln Ser Lys
        2195                2200                2205            
Lys Trp
    2210


<210> 5671
<211> 171
<212> PRT
<213> Homo sapiens

<400> 5671
Met Ser Ser Lys Arg Thr Lys Thr Lys Thr Lys Lys Arg Pro Gln Arg
 1               5                  10                  15      
Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln Glu
            20                  25                  30          
Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe Ile
        35                  40                  45              
Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn Pro
    50                  55                  60                  
Thr Asp Glu Tyr Leu Asp Ala Met Met Asn Glu Ala Pro Gly Pro Ile
65                  70                  75                  80  
Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly Thr
                85                  90                  95      
Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu
            100                 105                 110         
Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg Glu Leu Leu Thr Thr
        115                 120                 125             
Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Leu Tyr Arg Glu
    130                 135                 140                 
Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Ile Glu Phe Thr Arg
145                 150                 155                 160 
Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp
                165                 170     


<210> 5672
<211> 757
<212> PRT
<213> Homo sapiens

<400> 5672
Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu
 1               5                  10                  15      
Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro
            20                  25                  30          
Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val
        35                  40                  45              
Arg Asp Trp Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn
    50                  55                  60                  
Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr
65                  70                  75                  80  
Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys
                85                  90                  95      
Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Gly Arg Cys Gly
            100                 105                 110         
Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val
        115                 120                 125             
Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn
    130                 135                 140                 
Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly
145                 150                 155                 160 
Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln
                165                 170                 175     
Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val
            180                 185                 190         
Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro
        195                 200                 205             
Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Gly
    210                 215                 220                 
Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His
225                 230                 235                 240 
Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Arg
                245                 250                 255     
Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu
            260                 265                 270         
Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Pro Gln Cys Arg
        275                 280                 285             
Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp
    290                 295                 300                 
Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly
305                 310                 315                 320 
Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln
                325                 330                 335     
Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg
            340                 345                 350         
Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly
        355                 360                 365             
Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala
    370                 375                 380                 
Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly
385                 390                 395                 400 
Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro
                405                 410                 415     
Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser
            420                 425                 430         
Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys
        435                 440                 445             
Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln
    450                 455                 460                 
Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser
465                 470                 475                 480 
Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp
                485                 490                 495     
Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys
            500                 505                 510         
Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu
        515                 520                 525             
Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp
    530                 535                 540                 
Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile
545                 550                 555                 560 
Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala
                565                 570                 575     
Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr
            580                 585                 590         
Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser
        595                 600                 605             
Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala
    610                 615                 620                 
Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val
625                 630                 635                 640 
Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His
                645                 650                 655     
Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg
            660                 665                 670         
Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His
        675                 680                 685             
Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu
    690                 695                 700                 
Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly
705                 710                 715                 720 
Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn
                725                 730                 735     
Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His
            740                 745                 750         
Gln Leu Arg Gln Ala
        755         


<210> 5673
<211> 326
<212> PRT
<213> Homo sapiens

<400> 5673
Met Thr Gly Leu Cys Gly Tyr Ser Ala Pro Asp Met Arg Gly Leu Arg
 1               5                  10                  15      
Leu Ile Met Ile Pro Val Glu Leu Leu Leu Cys Tyr Leu Leu Leu His
            20                  25                  30          
Pro Val Asp Ala Thr Ser Tyr Gly Lys Gln Thr Asn Val Leu Met His
        35                  40                  45              
Phe Pro Leu Ser Leu Glu Ser Gln Thr Pro Ser Ser Asp Pro Leu Ser
    50                  55                  60                  
Cys Gln Phe Leu His Pro Lys Ser Leu Pro Gly Phe Ser His Met Ala
65                  70                  75                  80  
Pro Leu Pro Lys Phe Leu Val Ser Leu Ala Leu Arg Asn Ala Leu Glu
                85                  90                  95      
Glu Ala Gly Cys Gln Ala Asp Val Trp Ala Leu Gln Leu Gln Leu Tyr
            100                 105                 110         
Arg Gln Gly Gly Val Asn Ala Thr Gln Val Leu Ile Gln His Leu Arg
        115                 120                 125             
Gly Leu Gln Lys Gly Arg Ser Thr Glu Arg Asn Val Ser Val Glu Ala
    130                 135                 140                 
Leu Ala Ser Ala Leu Gln Leu Leu Ala Arg Glu Gln Gln Ser Thr Gly
145                 150                 155                 160 
Arg Val Gly Arg Ser Leu Pro Thr Glu Asp Cys Glu Asn Glu Lys Glu
                165                 170                 175     
Gln Ala Val His Asn Val Val Gln Leu Leu Pro Gly Val Gly Thr Phe
            180                 185                 190         
Tyr Asn Leu Gly Thr Ala Leu Tyr Tyr Ala Thr Gln Asn Cys Leu Gly
        195                 200                 205             
Lys Ala Arg Glu Arg Gly Arg Asp Gly Ala Ile Asp Leu Gly Tyr Asp
    210                 215                 220                 
Leu Leu Met Thr Met Ala Gly Met Ser Gly Gly Pro Met Gly Leu Ala
225                 230                 235                 240 
Ile Ser Ala Ala Leu Lys Pro Ala Leu Arg Ser Gly Val Gln Gln Leu
                245                 250                 255     
Ile Gln Tyr Tyr Gln Asp Gln Lys Asp Ala Asn Ile Ser Gln Pro Glu
            260                 265                 270         
Thr Thr Lys Glu Gly Leu Arg Ala Ile Ser Asp Val Ser Asp Leu Glu
        275                 280                 285             
Glu Thr Thr Thr Leu Ala Ser Phe Ile Ser Glu Val Val Ser Ser Ala
    290                 295                 300                 
Pro Tyr Trp Gly Trp Ala Ile Ile Lys Ser Tyr Asp Leu Asp Pro Gly
305                 310                 315                 320 
Ala Gly Ser Leu Glu Ile
                325     


<210> 5674
<211> 463
<212> PRT
<213> Homo sapiens

<400> 5674
Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu
 1               5                  10                  15      
Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu
            20                  25                  30          
Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser
        35                  40                  45              
Pro Pro Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala
    50                  55                  60                  
Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys
65                  70                  75                  80  
Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly
                85                  90                  95      
Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His
            100                 105                 110         
Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His
        115                 120                 125             
Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser
    130                 135                 140                 
His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu
145                 150                 155                 160 
Leu Val Cys Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro
                165                 170                 175     
Tyr Gln Gly Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys
            180                 185                 190         
Lys Asn Ser Leu Cys Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp
        195                 200                 205             
Leu Pro Tyr Leu Val Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala
    210                 215                 220                 
Ser Asp Ser Arg Lys Met Gly Thr Pro Ser Ser Leu Ala Thr Gly Ile
225                 230                 235                 240 
Pro Ala Phe Leu Val Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala
                245                 250                 255     
Leu Pro Ala Val Glu Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp
            260                 265                 270         
Pro Pro Ser Met Ala Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Ala
        275                 280                 285             
Pro Ser Ile Leu Ala Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro
    290                 295                 300                 
Val Thr Phe Pro Lys Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp
305                 310                 315                 320 
Lys Val Thr Asp Lys Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser
                325                 330                 335     
Leu Asp Pro Lys Met Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His
            340                 345                 350         
Ala Gln Glu Glu Ala Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu
        355                 360                 365             
Val Leu Ala Ser Val Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln
    370                 375                 380                 
Ala Thr Leu Asp His Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn
385                 390                 395                 400 
Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu
                405                 410                 415     
Ala Leu Gln Ser Ser Leu Pro Gly Ala Glu Gly Pro Asp Lys Pro Ser
            420                 425                 430         
Val Val Ser Gly Leu Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu
        435                 440                 445             
Leu Gly Leu Leu Leu Leu Pro Pro Leu Val Leu Ala Gly Ile Phe
    450                 455                 460             


<210> 5675
<211> 436
<212> PRT
<213> Homo sapiens

<400> 5675
Met Asp Gly Lys Pro Ala Thr Arg Lys Gly Pro Asp Phe Cys Ser Leu
 1               5                  10                  15      
Arg Tyr Gly Leu Ala Leu Ile Met His Phe Ser Asn Phe Thr Met Ile
            20                  25                  30          
Thr Gln Arg Val Ser Leu Ser Ile Ala Ile Ile Ala Met Val Asn Thr
        35                  40                  45              
Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr Glu Gly Pro Val Ala
    50                  55                  60                  
Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys Glu Phe Asp Thr Lys
65                  70                  75                  80  
Ala Ser Val Tyr Gln Trp Ser Pro Glu Thr Gln Gly Ile Ile Phe Ser
                85                  90                  95      
Ser Ile Asn Tyr Gly Ile Ile Leu Thr Leu Ile Pro Ser Gly Tyr Leu
            100                 105                 110         
Ala Gly Ile Phe Gly Ala Lys Lys Met Leu Gly Ala Gly Leu Leu Ile
        115                 120                 125             
Ser Ser Leu Leu Thr Leu Phe Thr Pro Leu Ala Ala Asp Phe Gly Val
    130                 135                 140                 
Ile Leu Val Ile Met Val Arg Thr Val Gln Gly Met Ala Gln Gly Met
145                 150                 155                 160 
Ala Trp Thr Gly Gln Phe Thr Ile Trp Ala Lys Trp Ala Pro Pro Leu
                165                 170                 175     
Glu Arg Ser Lys Leu Thr Thr Ile Ala Gly Ser Gly Ser Ala Phe Gly
            180                 185                 190         
Ser Phe Ile Ile Leu Cys Val Gly Gly Leu Ile Ser Gln Ala Leu Ser
        195                 200                 205             
Trp Pro Phe Ile Phe Tyr Ile Phe Gly Ser Thr Gly Cys Val Cys Cys
    210                 215                 220                 
Leu Leu Trp Phe Thr Val Ile Tyr Asp Asp Pro Met His His Pro Cys
225                 230                 235                 240 
Ile Ser Val Arg Glu Lys Glu His Ile Leu Ser Ser Leu Ala Gln Gln
                245                 250                 255     
Pro Ser Ser Pro Gly Arg Ala Val Pro Ile Lys Ala Met Val Thr Cys
            260                 265                 270         
Leu Pro Leu Trp Ala Ile Phe Leu Gly Phe Phe Ser His Phe Trp Leu
        275                 280                 285             
Cys Thr Ile Ile Leu Thr Tyr Leu Pro Thr Tyr Ile Ser Thr Leu Leu
    290                 295                 300                 
His Val Asn Ile Arg Asp Ser Gly Val Leu Ser Ser Leu Pro Phe Ile
305                 310                 315                 320 
Ala Ala Ala Ser Cys Thr Ile Leu Gly Gly Gln Leu Ala Asp Phe Leu
                325                 330                 335     
Leu Ser Arg Asn Leu Leu Arg Leu Ile Thr Val Arg Lys Leu Phe Ser
            340                 345                 350         
Ser Leu Asp Met Gln Val Ser Ser Trp Glu Ser Gln Gly Asp Leu Gly
        355                 360                 365             
Ser Ser Gln Glu Ser Ser Leu Pro Leu Pro Leu Asp Ser Ser Ser Val
    370                 375                 380                 
Arg Ile Leu Ser Leu Val Gly Gly Met Ser Phe Ser Cys Leu Leu Gln
385                 390                 395                 400 
Ser Thr Cys Leu Ala Trp Ser Phe Thr Ser Arg Leu Asp Lys Gln Asn
                405                 410                 415     
Phe Lys Thr Gly Pro Lys Arg Gly Pro Leu Pro Ala Ser Glu Asp Ile
            420                 425                 430         
Lys Leu Gln Thr
        435     


<210> 5676
<211> 466
<212> PRT
<213> Homo sapiens

<400> 5676
Phe Cys Ser Leu Arg Tyr Gly Leu Ala Leu Ile Met His Phe Ser Asn
 1               5                  10                  15      
Phe Thr Met Ile Thr Gln Arg Val Ser Leu Ser Ile Ala Ile Ile Ala
            20                  25                  30          
Met Val Asn Thr Thr Gln Gln Gln Gly Leu Ser Asn Ala Ser Thr Glu
        35                  40                  45              
Gly Pro Val Ala Asp Ala Phe Asn Asn Ser Ser Ile Ser Ile Lys Glu
    50                  55                  60                  
Phe Asp Thr Lys Ala Ser Val Tyr Gln Trp Ser Pro Glu Thr Gln Gly
65                  70                  75                  80  
Ile Ile Phe Ser Ser Ile Asn Tyr Gly Ile Ile Leu Thr Leu Ile Pro
                85                  90                  95      
Ser Gly Tyr Leu Ala Gly Ile Phe Gly Ala Lys Lys Met Leu Gly Ala
            100                 105                 110         
Gly Leu Leu Ile Ser Ser Leu Leu Thr Leu Phe Thr Pro Leu Ala Ala
        115                 120                 125             
Asp Phe Gly Val Ile Leu Val Ile Met Val Arg Thr Val Gln Gly Met
    130                 135                 140                 
Ala Gln Gly Met Ala Trp Thr Gly Gln Phe Thr Ile Trp Ala Lys Trp
145                 150                 155                 160 
Ala Pro Pro Leu Glu Arg Ser Lys Leu Thr Thr Ile Ala Gly Ser Gly
                165                 170                 175     
Ser Ala Phe Gly Ser Phe Ile Ile Leu Cys Val Gly Gly Leu Ile Ser
            180                 185                 190         
Gln Ala Leu Ser Trp Pro Phe Ile Phe Tyr Ile Phe Gly Ser Thr Gly
        195                 200                 205             
Cys Val Cys Cys Leu Leu Trp Phe Thr Val Ile Tyr Asp Asp Pro Met
    210                 215                 220                 
His His Pro Cys Ile Ser Val Arg Glu Lys Glu His Ile Leu Ser Ser
225                 230                 235                 240 
Leu Ala Gln Gln Pro Ser Ser Pro Gly Arg Ala Val Pro Ile Lys Ala
                245                 250                 255     
Met Val Thr Cys Leu Pro Leu Trp Ala Ile Phe Leu Gly Phe Phe Ser
            260                 265                 270         
His Phe Trp Leu Cys Thr Ile Ile Leu Thr Tyr Leu Pro Thr Tyr Ile
        275                 280                 285             
Ser Thr Leu Leu His Val Asn Ile Arg Asp Ser Gly Val Leu Ser Ser
    290                 295                 300                 
Leu Pro Phe Ile Ala Ala Ala Ser Cys Thr Ile Leu Gly Gly Gln Leu
305                 310                 315                 320 
Ala Asp Phe Leu Leu Ser Arg Asn Leu Leu Arg Leu Ile Thr Val Arg
                325                 330                 335     
Lys Leu Phe Ser Ser Leu Gly Leu Leu Leu Pro Ser Ile Cys Ala Val
            340                 345                 350         
Ala Leu Pro Phe Val Ala Ser Ser Tyr Val Ile Thr Ile Ile Leu Leu
        355                 360                 365             
Ile Leu Ile Pro Gly Thr Ser Asn Leu Cys Asp Ser Gly Phe Ile Ile
    370                 375                 380                 
Asn Thr Leu Asp Ile Ala Pro Arg Tyr Ala Ser Phe Leu Met Gly Ile
385                 390                 395                 400 
Ser Arg Gly Phe Gly Leu Ile Ala Gly Ile Ile Ser Ser Thr Ala Thr
                405                 410                 415     
Gly Phe Leu Ile Ser Gln Asp Phe Glu Ser Gly Trp Arg Asn Val Phe
            420                 425                 430         
Phe Leu Ser Ala Ala Val Asn Met Phe Gly Leu Val Phe Tyr Leu Thr
        435                 440                 445             
Phe Gly Gln Ala Glu Leu Gln Asp Trp Ala Lys Glu Arg Thr Leu Thr
    450                 455                 460                 
Arg Leu
465     


<210> 5677
<211> 791
<212> PRT
<213> Homo sapiens

<400> 5677
Met Trp Asn Met Leu Ile Val Ala Met Cys Leu Ala Leu Leu Gly Cys
 1               5                  10                  15      
Leu Gln Ala Gln Glu Leu Gln Gly His Val Ser Ile Ile Leu Leu Gly
            20                  25                  30          
Ala Thr Gly Asp Leu Ala Lys Lys Tyr Leu Trp Gln Gly Leu Phe Gln
        35                  40                  45              
Leu Tyr Leu Asp Glu Ala Gly Arg Gly His Ser Phe Ser Phe His Gly
    50                  55                  60                  
Ala Ala Leu Thr Ala Pro Lys Gln Gly Gln Glu Leu Met Ala Lys Ala
65                  70                  75                  80  
Leu Glu Ser Leu Ser Cys Pro Lys Asp Met Ala Pro Ser His Cys Ala
                85                  90                  95      
Glu His Lys Asp Gln Phe Leu Gln Leu Ser Gln Tyr Arg Gln Leu Lys
            100                 105                 110         
Thr Ala Glu Asp Tyr Gln Ala Leu Asn Lys Asp Ile Glu Ala Gln Leu
        115                 120                 125             
Gln His Ala Gly Leu Arg Glu Ala Gly Arg Ile Phe Tyr Phe Ser Val
    130                 135                 140                 
Pro Pro Phe Ala Tyr Glu Asp Ile Ala Arg Asn Ile Asn Ser Ser Cys
145                 150                 155                 160 
Arg Pro Gly Pro Gly Ala Trp Leu Arg Val Val Leu Glu Lys Pro Phe
                165                 170                 175     
Gly His Asp His Phe Ser Ala Gln Gln Leu Ala Thr Glu Leu Gly Thr
            180                 185                 190         
Phe Phe Gln Glu Glu Glu Met Tyr Arg Val Asp His Tyr Leu Gly Lys
        195                 200                 205             
Gln Ala Val Ala Gln Ile Leu Pro Phe Arg Asp Gln Asn Arg Lys Ala
    210                 215                 220                 
Leu Asp Gly Leu Trp Asn Arg His His Val Glu Arg Val Glu Ile Ile
225                 230                 235                 240 
Met Lys Glu Thr Val Asp Ala Glu Gly Arg Thr Ser Phe Tyr Glu Glu
                245                 250                 255     
Tyr Gly Val Ile Arg Asp Val Leu Gln Asn His Leu Thr Glu Val Leu
            260                 265                 270         
Thr Leu Val Ala Met Glu Leu Pro His Asn Val Ser Ser Ala Glu Ala
        275                 280                 285             
Val Leu Arg His Lys Leu Gln Val Phe Gln Ala Leu Arg Gly Leu Gln
    290                 295                 300                 
Arg Gly Ser Ala Val Val Gly Gln Tyr Gln Ser Tyr Ser Glu Gln Val
305                 310                 315                 320 
Arg Arg Glu Leu Gln Lys Pro Asp Ser Phe His Ser Leu Thr Pro Thr
                325                 330                 335     
Phe Ala Gly Val Leu Val His Ile Asp Asn Leu Arg Trp Glu Gly Val
            340                 345                 350         
Pro Phe Ile Leu Met Ser Gly Lys Ala Leu Asp Glu Arg Val Gly Tyr
        355                 360                 365             
Ala Arg Ile Leu Phe Lys Asn Gln Ala Cys Cys Val Gln Ser Glu Lys
    370                 375                 380                 
His Trp Ala Ala Ala Gln Ser Gln Cys Leu Pro Arg Gln Leu Val Phe
385                 390                 395                 400 
His Ile Gly His Gly Asp Leu Gly Ser Pro Ala Val Leu Val Ser Arg
                405                 410                 415     
Asn Leu Phe Arg Pro Ser Leu Pro Ser Ser Trp Lys Glu Met Glu Gly
            420                 425                 430         
Pro Pro Gly Leu Arg Leu Phe Gly Ser Pro Leu Ser Asp Tyr Tyr Ala
        435                 440                 445             
Tyr Ser Pro Val Arg Glu Arg Asp Ala His Ser Val Leu Leu Ser His
    450                 455                 460                 
Ile Phe His Gly Arg Lys Asn Phe Phe Ile Thr Thr Glu Asn Leu Leu
465                 470                 475                 480 
Ala Ser Trp Asn Phe Trp Thr Pro Leu Leu Glu Ser Leu Ala His Lys
                485                 490                 495     
Ala Pro Arg Leu Tyr Pro Gly Gly Ala Glu Asn Gly Arg Leu Leu Asp
            500                 505                 510         
Phe Glu Phe Ser Ser Gly Arg Leu Phe Phe Ser Gln Gln Gln Pro Glu
        515                 520                 525             
Gln Leu Val Pro Gly Pro Gly Pro Ala Pro Met Pro Ser Asp Phe Gln
    530                 535                 540                 
Val Leu Arg Ala Lys Tyr Arg Glu Ser Pro Leu Val Ser Ala Trp Ser
545                 550                 555                 560 
Glu Glu Leu Ile Ser Lys Leu Ala Asn Asp Ile Glu Ala Thr Ala Val
                565                 570                 575     
Arg Ala Val Arg Arg Phe Gly Gln Phe His Leu Ala Leu Ser Gly Gly
            580                 585                 590         
Ser Ser Pro Val Ala Leu Phe Gln Gln Leu Ala Thr Ala His Tyr Gly
        595                 600                 605             
Phe Pro Trp Ala His Thr His Leu Trp Leu Val Asp Glu Arg Cys Val
    610                 615                 620                 
Pro Leu Ser Asp Pro Glu Ser Asn Phe Gln Gly Leu Gln Ala His Leu
625                 630                 635                 640 
Leu Gln His Val Arg Ile Pro Tyr Tyr Asn Ile His Pro Met Pro Val
                645                 650                 655     
His Leu Gln Gln Arg Leu Cys Ala Glu Glu Asp Gln Gly Ala Gln Ile
            660                 665                 670         
Tyr Ala Arg Glu Ile Ser Ala Leu Val Ala Asn Ser Ser Phe Asp Leu
        675                 680                 685             
Val Leu Leu Gly Met Gly Ala Asp Gly His Thr Ala Ser Leu Phe Pro
    690                 695                 700                 
Gln Ser Pro Thr Gly Leu Asp Gly Glu Gln Leu Val Val Leu Thr Thr
705                 710                 715                 720 
Ser Pro Ser Gln Pro His Arg Arg Met Ser Leu Ser Leu Pro Leu Ile
                725                 730                 735     
Asn Arg Ala Lys Lys Val Ala Val Leu Val Met Gly Arg Met Lys Arg
            740                 745                 750         
Glu Ile Thr Thr Leu Val Ser Arg Val Gly His Glu Pro Lys Lys Trp
        755                 760                 765             
Pro Ile Ser Gly Val Leu Pro His Ser Gly Gln Leu Val Trp Tyr Met
    770                 775                 780                 
Asp Tyr Asp Ala Phe Leu Gly
785                 790     


<210> 5678
<211> 1321
<212> PRT
<213> Homo sapiens

<400> 5678
Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu
 1               5                  10                  15      
Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly
            20                  25                  30          
Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg
        35                  40                  45              
Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val
    50                  55                  60                  
Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Thr Leu Pro
65                  70                  75                  80  
Asn Arg Thr Val Thr Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu
                85                  90                  95      
Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu
            100                 105                 110         
Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu
        115                 120                 125             
Ser Ser Leu Lys Arg Leu Asp Leu Thr Asn Asn Arg Ile Gly Cys Leu
    130                 135                 140                 
Asn Ala Asp Ile Phe Arg Gly Leu Thr Asn Leu Val Arg Leu Asn Leu
145                 150                 155                 160 
Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Thr Phe Asp Tyr Leu
                165                 170                 175     
Ala Ser Leu Arg Ser Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp
            180                 185                 190         
Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr
        195                 200                 205             
Val Arg Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro
    210                 215                 220                 
Val Thr Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu
225                 230                 235                 240 
Leu Pro Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu
                245                 250                 255     
Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp
            260                 265                 270         
Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu
        275                 280                 285             
Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu
    290                 295                 300                 
Ile Ala Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly
305                 310                 315                 320 
Asn Trp Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr
                325                 330                 335     
Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu
            340                 345                 350         
Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala
        355                 360                 365             
Gly Ile Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly
    370                 375                 380                 
Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys
385                 390                 395                 400 
Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr
                405                 410                 415     
Ala Asn Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu
            420                 425                 430         
Asn Leu Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr
        435                 440                 445             
Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala
    450                 455                 460                 
Glu Met Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys
465                 470                 475                 480 
Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala
                485                 490                 495     
Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser
            500                 505                 510         
Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly
        515                 520                 525             
Gly Ala His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala
    530                 535                 540                 
Tyr Val Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe
545                 550                 555                 560 
Gln Lys Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg
                565                 570                 575     
Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn
            580                 585                 590         
Val Ser Asn Thr Phe Ser Ser Leu Ala Leu Lys Asn Thr Ile Val Glu
        595                 600                 605             
Ala Ser Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg
    610                 615                 620                 
Glu Leu Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala
625                 630                 635                 640 
Phe Arg Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu
                645                 650                 655     
Ala Asp Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu Thr
            660                 665                 670         
Lys Ile Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn Val
        675                 680                 685             
Thr Leu Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp
    690                 695                 700                 
Asp Phe Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys
705                 710                 715                 720 
His Ile Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr Ser
                725                 730                 735     
Leu Ser Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu Tyr
            740                 745                 750         
Thr Gln Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala Ile
        755                 760                 765             
Ile Leu Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His
    770                 775                 780                 
His Ser Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn
785                 790                 795                 800 
Leu Cys Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly Ile
                805                 810                 815     
Thr Gln Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu
            820                 825                 830         
His Tyr Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala Arg
        835                 840                 845             
Asn Ile Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp Pro
    850                 855                 860                 
Asp Glu Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile
865                 870                 875                 880 
Gly Gly Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala Asn
                885                 890                 895     
Ile Lys Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala
            900                 905                 910         
Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ser Phe Ile Thr
        915                 920                 925             
Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg
    930                 935                 940                 
His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Glu Gln Gln
945                 950                 955                 960 
Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn His Gln Asp Ser Met
                965                 970                 975     
Ser Leu Ser Leu Ile Ser Thr Ser Ala Leu Glu Asn Glu His Thr Phe
            980                 985                 990         
His Ser Gln Leu Leu Gly Ala Ser Leu Thr Leu Leu Leu Tyr Val Ala
        995                 1000                1005            
Leu Trp Met Phe Gly Ala Leu Ala Val Ser Leu Tyr Tyr Pro Leu Asp
    1010                1015                1020                
Leu Val Phe Ser Phe Val Phe Gly Ala Thr Ser Leu Ser Phe Ser Ala
1025                1030                1035                1040
Phe Phe Val Val His His Cys Val Asn Arg Glu Asp Val Arg Leu Ala
                1045                1050                1055    
Trp Ile Met Thr Cys Cys Pro Gly Arg Ser Ser Tyr Ser Val Gln Val
            1060                1065                1070        
Asn Val Gln Pro Pro Asn Ser Asn Gly Thr Asn Gly Glu Ala Pro Lys
        1075                1080                1085            
Cys Pro Asn Ser Ser Ala Glu Ser Ser Cys Thr Asn Lys Ser Ala Ser
    1090                1095                1100                
Ser Phe Lys Asn Ser Ser Gln Gly Cys Lys Leu Thr Asn Leu Gln Ala
1105                1110                1115                1120
Ala Ala Ala Gln Cys His Ala Asn Ser Leu Pro Leu Asn Ser Thr Pro
                1125                1130                1135    
Gln Leu Asp Asn Ser Leu Thr Glu His Ser Met Asp Asn Asp Ile Lys
            1140                1145                1150        
Met His Val Ala Pro Leu Glu Val Gln Phe Arg Thr Asn Val His Ser
        1155                1160                1165            
Ser Arg His His Lys Asn Arg Ser Lys Gly His Arg Ala Ser Arg Leu
    1170                1175                1180                
Thr Val Leu Arg Glu Tyr Ala Tyr Asp Val Pro Thr Ser Val Glu Gly
1185                1190                1195                1200
Ser Val Gln Asn Gly Leu Pro Lys Ser Arg Leu Gly Asn Asn Glu Gly
                1205                1210                1215    
His Ser Arg Ser Arg Arg Ala Tyr Leu Ala Tyr Arg Glu Arg Gln Tyr
            1220                1225                1230        
Asn Pro Pro Gln Gln Asp Ser Ser Asp Ala Cys Ser Thr Leu Pro Lys
        1235                1240                1245            
Ser Ser Arg Asn Phe Glu Lys Pro Val Ser Thr Thr Ser Lys Lys Asp
    1250                1255                1260                
Ala Leu Arg Lys Pro Ala Val Val Glu Leu Glu Asn Gln Gln Lys Ser
1265                1270                1275                1280
Tyr Gly Leu Asn Leu Ala Ile Gln Asn Gly Pro Ile Lys Ser Asn Gly
                1285                1290                1295    
Gln Glu Gly Pro Leu Leu Gly Thr Asp Ser Thr Gly Asn Val Arg Thr
            1300                1305                1310        
Gly Leu Trp Lys His Glu Thr Thr Val
        1315                1320    


<210> 5679
<211> 1178
<212> PRT
<213> Homo sapiens

<400> 5679
Met Met Arg Val Met Pro Cys Gln Val Asp Leu Thr Asn Asn Arg Ile
 1               5                  10                  15      
Gly Cys Leu Asn Ala Asp Ile Phe Arg Gly Leu Thr Asn Leu Val Arg
            20                  25                  30          
Leu Asn Leu Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Thr Phe
        35                  40                  45              
Asp Tyr Leu Ala Ser Leu Arg Ser Leu Glu Phe Gln Thr Glu Tyr Leu
    50                  55                  60                  
Leu Cys Asp Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys
65                  70                  75                  80  
Asn Ile Thr Val Arg Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln
                85                  90                  95      
Ala Gln Pro Val Thr Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro
            100                 105                 110         
Pro Leu Glu Leu Pro Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val
        115                 120                 125             
Val Phe Glu Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile
    130                 135                 140                 
Asp Gln Asp Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu
145                 150                 155                 160 
Thr Asp Glu Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn
                165                 170                 175     
Cys Ser Leu Ile Ala Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly
            180                 185                 190         
Ser Thr Gly Asn Trp Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn
        195                 200                 205             
Thr Arg Thr Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys
    210                 215                 220                 
Pro Pro Glu Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg
225                 230                 235                 240 
Thr Leu Ala Gly Ile Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His
                245                 250                 255     
Gly Ser Gly Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp
            260                 265                 270         
Arg Arg Cys Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg
        275                 280                 285             
Cys Gln Tyr Ala Asn Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln
    290                 295                 300                 
Met Pro Leu Asn Leu Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu
305                 310                 315                 320 
Ala Tyr Thr Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile
                325                 330                 335     
Phe Val Ala Glu Met Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu
            340                 345                 350         
Lys Ser Lys Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile
        355                 360                 365             
Met Leu Ala Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys
    370                 375                 380                 
Ala Cys Ser Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg
385                 390                 395                 400 
Leu Ala Gly Gly Ala His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala
                405                 410                 415     
Leu Glu Ala Tyr Val Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys
            420                 425                 430         
Thr Val Phe Gln Lys Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp
        435                 440                 445             
Tyr Gly Arg Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe
    450                 455                 460                 
Lys Cys Asn Val Ser Asn Thr Phe Ser Ser Leu Ala Leu Lys Gln Lys
465                 470                 475                 480 
Arg Glu Leu Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile
                485                 490                 495     
Ala Phe Arg Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn
            500                 505                 510         
Leu Ala Asp Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu
        515                 520                 525             
Thr Lys Ile Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn
    530                 535                 540                 
Val Thr Leu Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg
545                 550                 555                 560 
Trp Asp Phe Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly
                565                 570                 575     
Cys His Ile Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr
            580                 585                 590         
Ser Leu Ser Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu
        595                 600                 605             
Tyr Thr Gln Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala
    610                 615                 620                 
Ile Ile Leu Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr
625                 630                 635                 640 
His His Ser Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val
                645                 650                 655     
Asn Leu Cys Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly
            660                 665                 670         
Ile Thr Gln Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile
        675                 680                 685             
Leu His Tyr Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala
    690                 695                 700                 
Arg Asn Ile Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp
705                 710                 715                 720 
Pro Asp Glu Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu
                725                 730                 735     
Ile Gly Gly Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala
            740                 745                 750         
Asn Ile Lys Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met
        755                 760                 765             
Ala Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ser Phe Ile
    770                 775                 780                 
Thr Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys
785                 790                 795                 800 
Arg His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Glu Gln
                805                 810                 815     
Gln Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn His Gln Asp Ser
            820                 825                 830         
Met Ser Leu Ser Leu Ile Ser Thr Ser Ala Leu Glu Asn Glu His Thr
        835                 840                 845             
Phe His Ser Gln Leu Leu Gly Ala Ser Leu Thr Leu Leu Leu Tyr Val
    850                 855                 860                 
Ala Leu Trp Met Phe Gly Ala Leu Ala Val Ser Leu Tyr Tyr Pro Leu
865                 870                 875                 880 
Asp Leu Val Phe Ser Phe Val Phe Gly Ala Thr Ser Leu Ser Phe Ser
                885                 890                 895     
Ala Phe Phe Val Val His His Cys Val Asn Arg Glu Asp Val Arg Leu
            900                 905                 910         
Ala Trp Ile Met Thr Cys Cys Pro Gly Arg Ser Ser Tyr Ser Val Gln
        915                 920                 925             
Val Asn Val Gln Pro Pro Asn Ser Asn Gly Thr Asn Gly Glu Ala Pro
    930                 935                 940                 
Lys Cys Pro Asn Ser Ser Ala Glu Ser Ser Cys Thr Asn Lys Ser Ala
945                 950                 955                 960 
Ser Ser Phe Lys Asn Ser Ser Gln Gly Cys Lys Leu Thr Asn Leu Gln
                965                 970                 975     
Ala Ala Ala Ala Gln Cys His Ala Asn Ser Leu Pro Leu Asn Ser Thr
            980                 985                 990         
Pro Gln Leu Asp Asn Ser Leu Thr Glu His Ser Met Asp Asn Asp Ile
        995                 1000                1005            
Lys Met His Val Ala Pro Leu Glu Val Gln Phe Arg Thr Asn Val His
    1010                1015                1020                
Ser Ser Arg His His Lys Asn Arg Ser Lys Gly His Arg Ala Ser Arg
1025                1030                1035                1040
Leu Thr Val Leu Arg Glu Tyr Ala Tyr Asp Val Pro Thr Ser Val Glu
                1045                1050                1055    
Gly Ser Val Gln Asn Gly Leu Pro Lys Ser Arg Leu Gly Asn Asn Glu
            1060                1065                1070        
Gly His Ser Arg Ser Arg Arg Ala Tyr Leu Ala Tyr Arg Glu Arg Gln
        1075                1080                1085            
Tyr Asn Pro Pro Gln Gln Asp Ser Ser Asp Ala Cys Ser Thr Leu Pro
    1090                1095                1100                
Lys Ser Ser Arg Asn Phe Glu Lys Pro Val Ser Thr Thr Ser Lys Lys
1105                1110                1115                1120
Asp Ala Leu Arg Lys Pro Ala Val Val Glu Leu Glu Asn Gln Gln Lys
                1125                1130                1135    
Ser Tyr Gly Leu Asn Leu Ala Ile Gln Asn Gly Pro Ile Lys Ser Asn
            1140                1145                1150        
Gly Gln Glu Gly Pro Leu Leu Gly Thr Asp Ser Thr Gly Asn Val Arg
        1155                1160                1165            
Thr Gly Leu Trp Lys His Glu Thr Thr Val
    1170                1175            


<210> 5680
<211> 1940
<212> PRT
<213> Homo sapiens

<400> 5680
Met Ser Ser Asp Thr Glu Met Glu Val Phe Gly Ile Ala Ala Pro Phe
 1               5                  10                  15      
Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Gln Pro Phe
            20                  25                  30          
Asp Ala Lys Thr Tyr Cys Phe Val Val Asp Ser Lys Glu Glu Tyr Ala
        35                  40                  45              
Lys Gly Lys Ile Lys Ser Ser Gln Asp Gly Lys Val Thr Val Glu Thr
    50                  55                  60                  
Glu Asp Asn Arg Thr Leu Val Val Lys Pro Glu Asp Val Tyr Ala Met
65                  70                  75                  80  
Asn Pro Pro Lys Phe Asp Arg Ile Glu Asp Met Ala Met Leu Thr His
                85                  90                  95      
Leu Asn Glu Pro Ala Val Leu Tyr Asn Leu Lys Asp Arg Tyr Thr Ser
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Asn Pro Glu Val Val Glu Gly Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Ala Thr Gly Asp Leu Ala Lys Lys
        195                 200                 205             
Lys Asp Ser Lys Met Lys Gly Thr Leu Glu Asp Gln Ile Ile Ser Ala
    210                 215                 220                 
Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp
225                 230                 235                 240 
Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Thr Thr
                245                 250                 255     
Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser
            260                 265                 270         
Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile Phe Tyr
        275                 280                 285             
Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Ile Glu Leu Leu Leu Ile
    290                 295                 300                 
Thr Thr Asn Pro Tyr Asp Tyr Pro Phe Ile Ser Gln Gly Glu Ile Leu
305                 310                 315                 320 
Val Ala Ser Ile Asp Asp Arg Glu Glu Leu Leu Ala Thr Asp Ser Ala
                325                 330                 335     
Ile Asp Ile Leu Gly Phe Thr Pro Glu Glu Lys Ser Gly Leu Tyr Lys
            340                 345                 350         
Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys Gln Lys
        355                 360                 365             
Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala Asp Lys
    370                 375                 380                 
Thr Ala Tyr Leu Met Gly Leu Asn Ser Ser Asp Leu Leu Lys Ala Leu
385                 390                 395                 400 
Cys Phe Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln
                405                 410                 415     
Thr Val Asp Gln Val His His Ala Val Asn Ala Leu Ser Lys Ser Val
            420                 425                 430         
Tyr Glu Lys Leu Phe Leu Trp Met Val Thr Arg Ile Asn Gln Gln Leu
        435                 440                 445             
Asp Thr Lys Leu Pro Arg Gln His Phe Ile Gly Val Leu Asp Ile Ala
    450                 455                 460                 
Gly Phe Glu Ile Phe Glu Tyr Asn Ser Leu Glu Gln Leu Cys Ile Asn
465                 470                 475                 480 
Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val
                485                 490                 495     
Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile
            500                 505                 510         
Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu Lys Pro
        515                 520                 525             
Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala
    530                 535                 540                 
Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu Gly Lys
545                 550                 555                 560 
Ser Asn Asn Phe Gln Lys Pro Lys Val Val Lys Gly Arg Ala Glu Ala
                565                 570                 575     
His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Ser Val Ser
            580                 585                 590         
Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly
        595                 600                 605             
Leu Tyr Gln Lys Ser Ser Asn Arg Leu Leu Ala His Leu Tyr Ala Thr
    610                 615                 620                 
Phe Ala Thr Ala Asp Ala Asp Ser Gly Lys Lys Lys Val Ala Lys Lys
625                 630                 635                 640 
Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu Asn Leu
                645                 650                 655     
Asn Lys Leu Met Ser Asn Leu Arg Thr Thr His Pro His Phe Val Arg
            660                 665                 670         
Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu His Ser
        675                 680                 685             
Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg
    690                 695                 700                 
Ile Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Lys
705                 710                 715                 720 
Gln Arg Tyr Arg Val Leu Asn Ala Ser Ala Ile Leu Glu Gly Gln Phe
                725                 730                 735     
Ile Asp Ser Lys Lys Ala Cys Glu Lys Leu Leu Ala Ser Ile Asp Ile
            740                 745                 750         
Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala
        755                 760                 765             
Gly Leu Leu Gly Thr Leu Glu Glu Met Arg Asp Asp Arg Leu Ala Lys
    770                 775                 780                 
Leu Ile Thr Arg Thr Gln Ala Val Cys Arg Gly Phe Leu Met Arg Val
785                 790                 795                 800 
Glu Phe Gln Lys Met Val Gln Arg Arg Glu Ser Ile Phe Cys Ile Gln
                805                 810                 815     
Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His Trp Pro Trp Met Lys
            820                 825                 830         
Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu Lys
        835                 840                 845             
Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys Thr Lys Asp Glu Leu
    850                 855                 860                 
Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Leu Val Thr
865                 870                 875                 880 
Leu Val Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Ser
                885                 890                 895     
Glu Asn Leu Leu Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Ala
            900                 905                 910         
Lys Phe Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu Arg Ala Glu
        915                 920                 925             
Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu
    930                 935                 940                 
Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu Leu
945                 950                 955                 960 
Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val
                965                 970                 975     
Lys Asn Leu Thr Glu Glu Leu Ser Gly Leu Asp Glu Thr Ile Ala Lys
            980                 985                 990         
Leu Thr Arg Glu Lys Lys Ala Leu Gln Glu Ala His Gln Gln Ala Leu
        995                 1000                1005            
Asp Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Ser Leu Asn Lys Thr
    1010                1015                1020                
Lys Ser Lys Leu Glu Gln Gln Val Glu Asp Leu Glu Ser Ser Leu Glu
1025                1030                1035                1040
Gln Glu Lys Lys Leu Arg Val Asp Leu Glu Arg Asn Lys Arg Lys Leu
                1045                1050                1055    
Glu Gly Asp Leu Lys Leu Ala Gln Glu Ser Ile Leu Asp Leu Glu Asn
            1060                1065                1070        
Asp Lys Gln Gln Leu Asp Glu Arg Leu Lys Lys Lys Asp Phe Glu Tyr
        1075                1080                1085            
Cys Gln Leu Gln Ser Lys Val Glu Asp Glu Gln Thr Leu Gly Leu Gln
    1090                1095                1100                
Phe Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu Glu Leu Glu
1105                1110                1115                1120
Glu Glu Ile Glu Ala Glu Arg Ala Thr Arg Ala Lys Thr Glu Lys Gln
                1125                1130                1135    
Arg Ser Asp Tyr Ala Arg Glu Leu Glu Glu Leu Ser Glu Arg Leu Glu
            1140                1145                1150        
Glu Ala Gly Gly Val Thr Ser Thr Gln Ile Glu Leu Asn Lys Lys Arg
        1155                1160                1165            
Glu Ala Glu Phe Leu Lys Leu Arg Arg Asp Leu Glu Glu Ala Thr Leu
    1170                1175                1180                
Gln His Glu Ala Met Val Ala Thr Leu Arg Lys Lys His Ala Asp Ser
1185                1190                1195                1200
Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg Val Lys Gln
                1205                1210                1215    
Lys Leu Glu Lys Glu Lys Ser Glu Phe Lys Leu Glu Ile Asp Asp Leu
            1220                1225                1230        
Ser Ser Ser Met Glu Ser Val Ser Lys Ser Lys Ala Asn Leu Glu Lys
        1235                1240                1245            
Ile Cys Arg Thr Leu Glu Asp Gln Leu Ser Glu Ala Arg Gly Lys Asn
    1250                1255                1260                
Glu Glu Ile Gln Arg Ser Leu Ser Glu Leu Thr Thr Gln Lys Ser Arg
1265                1270                1275                1280
Leu Gln Thr Glu Ala Gly Glu Leu Ser Arg Gln Leu Glu Glu Lys Glu
                1285                1290                1295    
Ser Ile Val Ser Gln Leu Ser Arg Ser Lys Gln Ala Phe Thr Gln Gln
            1300                1305                1310        
Thr Glu Glu Leu Lys Arg Gln Leu Glu Glu Glu Asn Lys Ala Lys Asn
        1315                1320                1325            
Ala Leu Ala His Ala Leu Gln Ser Ser Arg His Asp Cys Asp Leu Leu
    1330                1335                1340                
Arg Glu Gln Tyr Glu Glu Glu Gln Glu Gly Lys Ala Glu Leu Gln Arg
1345                1350                1355                1360
Ala Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg Thr Lys Tyr
                1365                1370                1375    
Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu Ala Lys Lys
            1380                1385                1390        
Lys Leu Ala Gln Arg Leu Gln Asp Ser Glu Glu Gln Val Glu Ala Val
        1395                1400                1405            
Asn Ala Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg Leu Gln Gly
    1410                1415                1420                
Glu Val Glu Asp Leu Met Val Asp Val Glu Arg Ala Asn Ser Leu Ala
1425                1430                1435                1440
Ala Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Val Leu Ala Glu
                1445                1450                1455    
Trp Lys Thr Lys Cys Glu Glu Ser Gln Ala Glu Leu Glu Ala Ser Leu
            1460                1465                1470        
Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Leu Lys Asn Ala
        1475                1480                1485            
Tyr Glu Glu Ala Leu Asp Gln Leu Glu Thr Val Lys Arg Glu Asn Lys
    1490                1495                1500                
Asn Leu Glu Gln Glu Ile Ala Asp Leu Thr Glu Gln Ile Ala Glu Asn
1505                1510                1515                1520
Gly Lys Thr Ile His Glu Leu Glu Lys Ser Arg Lys Gln Ile Glu Leu
                1525                1530                1535    
Glu Lys Ala Asp Ile Gln Leu Ala Leu Glu Glu Ala Glu Ala Ala Leu
            1540                1545                1550        
Glu His Glu Glu Ala Lys Ile Leu Arg Ile Gln Leu Glu Leu Thr Gln
        1555                1560                1565            
Val Lys Ser Glu Ile Asp Arg Lys Ile Ala Glu Lys Asp Glu Glu Ile
    1570                1575                1580                
Glu Gln Leu Lys Arg Asn Tyr Gln Arg Thr Val Glu Thr Met Gln Ser
1585                1590                1595                1600
Ala Leu Asp Ala Glu Val Arg Ser Arg Asn Glu Ala Ile Arg Leu Lys
                1605                1610                1615    
Lys Lys Met Glu Gly Asp Leu Asn Glu Ile Glu Ile Gln Leu Ser His
            1620                1625                1630        
Ala Asn Arg Gln Ala Ala Glu Thr Leu Lys His Leu Arg Ser Val Gln
        1635                1640                1645            
Gly Gln Leu Lys Asp Thr Gln Leu His Leu Asp Asp Ala Leu Arg Gly
    1650                1655                1660                
Gln Glu Asp Leu Lys Glu Gln Leu Ala Ile Val Glu Arg Arg Ala Asn
1665                1670                1675                1680
Leu Leu Gln Ala Glu Val Glu Glu Leu Arg Ala Thr Leu Glu Gln Thr
                1685                1690                1695    
Glu Arg Ala Arg Lys Leu Ala Glu Gln Glu Leu Leu Asp Ser Asn Glu
            1700                1705                1710        
Arg Val Gln Leu Leu His Thr Gln Asn Thr Ser Leu Ile His Thr Lys
        1715                1720                1725            
Lys Lys Leu Glu Thr Asp Leu Met Gln Leu Gln Ser Glu Val Glu Asp
    1730                1735                1740                
Ala Ser Arg Asp Ala Arg Asn Ala Glu Glu Lys Ala Lys Lys Ala Ile
1745                1750                1755                1760
Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu Gln Asp Thr
                1765                1770                1775    
Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln Thr Val Lys
            1780                1785                1790        
Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala Leu Lys Gly
        1795                1800                1805            
Gly Lys Lys Gln Ile Gln Lys Leu Glu Thr Arg Ile Arg Glu Leu Glu
    1810                1815                1820                
Phe Glu Leu Glu Gly Glu Gln Lys Lys Asn Thr Glu Ser Val Lys Gly
1825                1830                1835                1840
Leu Arg Lys Tyr Glu Arg Arg Val Lys Glu Leu Thr Tyr Gln Ser Glu
                1845                1850                1855    
Glu Asp Arg Lys Asn Val Leu Arg Leu Gln Asp Leu Val Asp Lys Leu
            1860                1865                1870        
Gln Val Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu Ala Asp Glu
        1875                1880                1885            
Gln Ala Asn Ala His Leu Thr Lys Phe Arg Lys Ala Gln His Glu Leu
    1890                1895                1900                
Glu Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln Val Asn Lys
1905                1910                1915                1920
Leu Arg Ala Lys Thr Arg Asp Phe Thr Ser Ser Arg Met Val Val His
                1925                1930                1935    
Glu Ser Glu Glu
            1940


<210> 5681
<211> 1937
<212> PRT
<213> Homo sapiens

<400> 5681
Met Ser Ala Ser Ser Asp Ala Glu Met Ala Val Phe Gly Glu Ala Ala
 1               5                  10                  15      
Pro Tyr Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Lys
            20                  25                  30          
Pro Phe Asp Ala Lys Thr Ser Val Phe Val Ala Glu Pro Lys Glu Ser
        35                  40                  45              
Tyr Val Lys Ser Thr Ile Gln Ser Lys Glu Gly Gly Lys Val Thr Val
    50                  55                  60                  
Lys Thr Glu Gly Gly Ala Thr Leu Thr Val Arg Glu Asp Gln Val Phe
65                  70                  75                  80  
Pro Met Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met
                85                  90                  95      
Thr His Leu His Glu Pro Gly Val Leu Tyr Asn Leu Lys Glu Arg Tyr
            100                 105                 110         
Ala Ala Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val
        115                 120                 125             
Asn Pro Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Ala Ala
    130                 135                 140                 
Tyr Arg Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile
145                 150                 155                 160 
Ser Asp Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser
                165                 170                 175     
Ile Leu Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys
            180                 185                 190         
Arg Val Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys
        195                 200                 205             
Lys Asp Glu Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile
    210                 215                 220                 
Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg
225                 230                 235                 240 
Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly
                245                 250                 255     
Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu
            260                 265                 270         
Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile
        275                 280                 285             
Phe Tyr Gln Ile Thr Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu
    290                 295                 300                 
Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu
305                 310                 315                 320 
Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp
                325                 330                 335     
Ser Ala Ile Asp Ile Leu Gly Phe Thr Pro Glu Glu Lys Val Ser Ile
            340                 345                 350         
Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys
        355                 360                 365             
Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala
    370                 375                 380                 
Asp Lys Ala Ala Tyr Leu Gln Ser Leu Asn Ser Ala Asp Leu Leu Lys
385                 390                 395                 400 
Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys
                405                 410                 415     
Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys
            420                 425                 430         
Ala Val Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln
        435                 440                 445             
Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp
    450                 455                 460                 
Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys
465                 470                 475                 480 
Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met
                485                 490                 495     
Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr
            500                 505                 510         
Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu
        515                 520                 525             
Lys Pro Leu Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro
    530                 535                 540                 
Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu
545                 550                 555                 560 
Gly Lys Ser Ala Asn Phe Gln Lys Pro Lys Val Val Lys Gly Lys Ala
                565                 570                 575     
Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn
            580                 585                 590         
Ile Thr Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Asp Thr Val
        595                 600                 605             
Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Ser Leu Phe
    610                 615                 620                 
Ser Thr Tyr Ala Ser Ala Glu Ala Asp Ser Ser Ala Lys Lys Gly Ala
625                 630                 635                 640 
Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu
                645                 650                 655     
Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe
            660                 665                 670         
Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu
        675                 680                 685             
His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly
    690                 695                 700                 
Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Gly Asp
705                 710                 715                 720 
Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu Gly
                725                 730                 735     
Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Ala Ser Ile
            740                 745                 750         
Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe
        755                 760                 765             
Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys Leu
    770                 775                 780                 
Ala Gln Ile Ile Thr Arg Thr Gln Ala Val Cys Arg Gly Phe Leu Met
785                 790                 795                 800 
Arg Val Glu Tyr Gln Lys Met Leu Gln Arg Arg Glu Ala Leu Phe Cys
                805                 810                 815     
Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro Trp
            820                 825                 830         
Met Lys Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr
        835                 840                 845             
Glu Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys Thr Lys Asp
    850                 855                 860                 
Glu Leu Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Met
865                 870                 875                 880 
Val Thr Leu Leu Lys Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ser
                885                 890                 895     
Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Glu Gln Leu Ile
            900                 905                 910         
Lys Asn Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu Arg
        915                 920                 925             
Ala Glu Glu Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg
    930                 935                 940                 
Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu
945                 950                 955                 960 
Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn
                965                 970                 975     
Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr Ile
            980                 985                 990         
Ala Lys Leu Ser Lys Glu Lys Lys Ala Leu Gln Glu Thr His Gln Gln
        995                 1000                1005            
Thr Leu Asp Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Ile Leu Thr
    1010                1015                1020                
Lys Ala Lys Thr Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly Ser
1025                1030                1035                1040
Leu Glu Gln Glu Lys Lys Leu Arg Met Asp Leu Glu Arg Ala Lys Arg
                1045                1050                1055    
Lys Leu Glu Gly Asp Leu Lys Leu Ala Gln Glu Ser Thr Met Asp Met
            1060                1065                1070        
Glu Asn Asp Lys Gln Gln Leu Asp Glu Lys Leu Glu Lys Lys Glu Phe
        1075                1080                1085            
Glu Ile Ser Asn Leu Ile Ser Lys Ile Glu Asp Glu Gln Ala Val Glu
    1090                1095                1100                
Ile Gln Leu Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu Glu
1105                1110                1115                1120
Leu Gly Glu Glu Ile Glu Ala Glu Arg Ala Ser Arg Ala Lys Ala Glu
                1125                1130                1135    
Lys Gln Arg Ser Asp Leu Ser Arg Glu Leu Glu Glu Ile Ser Glu Arg
            1140                1145                1150        
Leu Glu Glu Ala Gly Gly Ala Thr Ser Ala Gln Val Glu Leu Asn Lys
        1155                1160                1165            
Lys Arg Glu Ala Glu Phe Gln Lys Leu Arg Arg Asp Leu Glu Glu Ala
    1170                1175                1180                
Thr Leu Gln His Glu Ala Met Val Ala Ala Leu Arg Lys Lys His Ala
1185                1190                1195                1200
Asp Ser Met Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg Val
                1205                1210                1215    
Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Leu Lys Met Glu Thr Asp
            1220                1225                1230        
Asp Leu Ser Ser Asn Ala Glu Ala Ile Ser Lys Ala Lys Gly Asn Leu
        1235                1240                1245            
Glu Lys Met Cys Arg Ser Leu Glu Asp Gln Val Ser Glu Leu Lys Thr
    1250                1255                1260                
Lys Glu Glu Glu Gln Gln Arg Leu Ile Asn Asp Leu Thr Ala Gln Arg
1265                1270                1275                1280
Ala Arg Leu Gln Thr Glu Ala Gly Glu Tyr Ser Arg Gln Leu Asp Glu
                1285                1290                1295    
Lys Asp Ala Leu Val Ser Gln Leu Ser Arg Ser Lys Gln Ala Ser Thr
            1300                1305                1310        
Gln Gln Ile Glu Glu Leu Lys His Gln Leu Glu Glu Glu Thr Lys Ala
        1315                1320                1325            
Lys Asn Ala Leu Ala His Ala Leu Gln Ser Ser Arg His Asp Cys Asp
    1330                1335                1340                
Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Gly Lys Ala Glu Leu
1345                1350                1355                1360
Gln Arg Ala Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg Thr
                1365                1370                1375    
Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu Ala
            1380                1385                1390        
Lys Lys Lys Leu Ala Gln Arg Leu Gln Glu Ala Glu Glu His Val Glu
        1395                1400                1405            
Ala Val Asn Ala Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg Leu
    1410                1415                1420                
Gln Asn Glu Val Glu Asp Leu Met Leu Asp Val Glu Arg Ser Asn Ala
1425                1430                1435                1440
Ala Cys Ala Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Val Leu
                1445                1450                1455    
Ser Glu Trp Lys Gln Lys Tyr Glu Glu Thr Gln Ala Glu Leu Glu Ala
            1460                1465                1470        
Ser Gln Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Val Lys
        1475                1480                1485            
Asn Val Tyr Glu Glu Ser Leu Asp Gln Leu Glu Thr Leu Arg Arg Glu
    1490                1495                1500                
Asn Lys Asn Leu Gln Gln Glu Ile Ser Asp Leu Thr Glu Gln Ile Ala
1505                1510                1515                1520
Glu Gly Gly Lys Gln Ile His Glu Leu Glu Lys Ile Lys Lys Gln Val
                1525                1530                1535    
Glu Gln Glu Lys Cys Glu Ile Gln Ala Ala Leu Glu Glu Ala Glu Ala
            1540                1545                1550        
Ser Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ile Gln Leu Glu Leu
        1555                1560                1565            
Asn Gln Val Lys Ser Glu Val Asp Arg Lys Ile Ala Glu Lys Asp Glu
    1570                1575                1580                
Glu Ile Asp Gln Leu Lys Arg Asn His Thr Arg Val Val Glu Thr Met
1585                1590                1595                1600
Gln Ser Thr Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp Ala Leu Arg
                1605                1610                1615    
Val Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln Leu
            1620                1625                1630        
Asn His Ala Asn Arg Leu Ala Ala Glu Ser Leu Arg Asn Tyr Arg Asn
        1635                1640                1645            
Thr Gln Gly Ile Leu Lys Glu Thr Gln Leu His Leu Asp Asp Ala Leu
    1650                1655                1660                
Arg Gly Gln Glu Asp Leu Lys Glu Gln Leu Ala Ile Val Glu Arg Arg
1665                1670                1675                1680
Ala Asn Leu Leu Gln Ala Glu Ile Glu Glu Leu Trp Ala Thr Leu Glu
                1685                1690                1695    
Gln Thr Glu Arg Ser Arg Lys Ile Ala Glu Gln Glu Leu Leu Asp Ala
            1700                1705                1710        
Ser Glu Arg Val Gln Leu Leu His Thr Gln Asn Thr Ser Leu Ile Asn
        1715                1720                1725            
Thr Lys Lys Lys Leu Glu Asn Asp Val Ser Gln Leu Gln Ser Glu Val
    1730                1735                1740                
Glu Glu Val Ile Gln Glu Ser Arg Asn Ala Glu Glu Lys Ala Lys Lys
1745                1750                1755                1760
Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu Gln
                1765                1770                1775    
Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln Thr
            1780                1785                1790        
Val Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala Leu
        1795                1800                1805            
Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Ala Arg Val Arg Glu
    1810                1815                1820                
Leu Glu Gly Glu Val Glu Asn Glu Gln Lys Arg Asn Ala Glu Ala Val
1825                1830                1835                1840
Lys Gly Leu Arg Lys His Glu Arg Arg Val Lys Glu Leu Thr Tyr Gln
                1845                1850                1855    
Thr Glu Glu Asp Arg Lys Asn Val Leu Arg Leu Gln Asp Leu Val Asp
            1860                1865                1870        
Lys Leu Gln Ala Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu Ala
        1875                1880                1885            
Glu Glu Gln Ser Asn Ala Asn Leu Ser Lys Phe Arg Lys Leu Gln His
    1890                1895                1900                
Glu Leu Glu Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln Val
1905                1910                1915                1920
Asn Lys Leu Arg Val Lys Ser Arg Glu Val His Thr Lys Ile Ser Ala
                1925                1930                1935    
Glu
    


<210> 5682
<211> 1935
<212> PRT
<213> Homo sapiens

<400> 5682
Met Gly Asp Ser Glu Met Ala Val Phe Gly Ala Ala Ala Pro Tyr Leu
 1               5                  10                  15      
Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp
            20                  25                  30          
Leu Lys Lys Asp Val Phe Val Pro Asp Asp Lys Gln Glu Phe Val Lys
        35                  40                  45              
Ala Lys Ile Val Ser Arg Glu Gly Gly Lys Val Thr Ala Glu Thr Glu
    50                  55                  60                  
Tyr Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Met Gln Gln Asn
65                  70                  75                  80  
Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu
                85                  90                  95      
His Glu Pro Ala Val Leu Tyr Asn Leu Lys Asp Arg Tyr Gly Ser Trp
            100                 105                 110         
Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr
        115                 120                 125             
Lys Trp Leu Pro Val Tyr Thr Pro Glu Val Val Ala Ala Tyr Arg Gly
    130                 135                 140                 
Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn
145                 150                 155                 160 
Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile
                165                 170                 175     
Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile
            180                 185                 190         
Gln Tyr Phe Ala Val Ile Ala Ala Ile Gly Asp Arg Ser Lys Lys Asp
        195                 200                 205             
Gln Ser Pro Gly Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala Asn
    210                 215                 220                 
Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp Asn
225                 230                 235                 240 
Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr Gly
                245                 250                 255     
Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg
            260                 265                 270         
Val Ile Phe Gln Leu Lys Ala Glu Arg Asp Tyr His Ile Phe Tyr Gln
        275                 280                 285             
Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Ile Thr
    290                 295                 300                 
Asn Asn Pro Tyr Asp Tyr Ala Phe Ile Ser Gln Gly Glu Thr Thr Val
305                 310                 315                 320 
Ala Ser Ile Asp Asp Ala Glu Glu Leu Met Ala Thr Asp Asn Ala Phe
                325                 330                 335     
Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Asn Ser Met Tyr Lys Leu
            340                 345                 350         
Thr Gly Ala Ile Met His Phe Gly Asn Met Lys Phe Lys Leu Lys Gln
        355                 360                 365             
Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Glu Ala Asp Lys Ser
    370                 375                 380                 
Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu Cys
385                 390                 395                 400 
His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln Asn
                405                 410                 415     
Val Gln Gln Val Ile Tyr Ala Thr Gly Ala Leu Ala Lys Ala Val Tyr
            420                 425                 430         
Glu Arg Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu Glu
        435                 440                 445             
Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly
    450                 455                 460                 
Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe
465                 470                 475                 480 
Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val Leu
                485                 490                 495     
Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile Asp
            500                 505                 510         
Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met
        515                 520                 525             
Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr
    530                 535                 540                 
Asp Met Thr Phe Lys Ala Lys Leu Phe Asp Asn His Leu Gly Lys Ser
545                 550                 555                 560 
Ala Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Pro Glu Ala His
                565                 570                 575     
Phe Ser Leu Ile His Tyr Ala Gly Ile Val Asp Tyr Asn Ile Ile Gly
            580                 585                 590         
Trp Leu Gln Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly Leu
        595                 600                 605             
Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Thr Leu Phe Ala Asn Tyr
    610                 615                 620                 
Ala Gly Ala Asp Ala Pro Ile Glu Lys Gly Lys Gly Lys Ala Lys Lys
625                 630                 635                 640 
Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn Leu Asn
                645                 650                 655     
Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe Val Arg Cys
            660                 665                 670         
Ile Ile Pro Asn Glu Thr Lys Ser Pro Gly Val Met Asp Asn Pro Leu
        675                 680                 685             
Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile
    690                 695                 700                 
Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Arg Gln
705                 710                 715                 720 
Arg Tyr Arg Ile Leu Asn Pro Ala Ala Ile Pro Glu Gly Gln Phe Ile
                725                 730                 735     
Asp Ser Arg Lys Gly Ala Glu Lys Leu Leu Ser Ser Leu Asp Ile Asp
            740                 745                 750         
His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala Gly
        755                 760                 765             
Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser Arg Ile
    770                 775                 780                 
Ile Thr Arg Ile Gln Ala Gln Ser Arg Gly Val Leu Ala Arg Met Glu
785                 790                 795                 800 
Tyr Lys Lys Leu Leu Glu Arg Arg Asp Ser Leu Leu Val Ile Gln Trp
                805                 810                 815     
Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met Lys Leu
            820                 825                 830         
Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Arg Glu Lys Glu
        835                 840                 845             
Met Ala Ser Met Lys Glu Glu Phe Thr Arg Leu Lys Glu Ala Leu Glu
    850                 855                 860                 
Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val Ser Leu
865                 870                 875                 880 
Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Gln Asp
                885                 890                 895     
Asn Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Asn Lys
            900                 905                 910         
Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu Glu Asp
        915                 920                 925             
Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu Glu
    930                 935                 940                 
Asp Glu Cys Ser Glu Leu Lys Arg Asp Ile Asp Asp Leu Glu Leu Thr
945                 950                 955                 960 
Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val Lys
                965                 970                 975     
Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala Lys Leu
            980                 985                 990         
Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala His Gln Gln Ala Leu Asp
        995                 1000                1005            
Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Thr Leu Thr Lys Ala Lys
    1010                1015                1020                
Val Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly Ser Leu Glu Gln
1025                1030                1035                1040
Glu Lys Lys Val Arg Met Asp Leu Glu Arg Ala Lys Arg Lys Leu Glu
                1045                1050                1055    
Gly Asp Leu Lys Leu Thr Gln Glu Ser Ile Met Asp Leu Glu Asn Asp
            1060                1065                1070        
Lys Gln Gln Leu Asp Glu Arg Leu Lys Lys Lys Asp Phe Glu Leu Asn
        1075                1080                1085            
Ala Leu Asn Ala Arg Ile Glu Asp Glu Gln Ala Leu Gly Ser Gln Leu
    1090                1095                1100                
Gln Lys Lys Leu Lys Glu Leu Gln Ala Arg Ile Glu Glu Leu Glu Glu
1105                1110                1115                1120
Glu Leu Glu Ser Glu Arg Thr Ala Arg Ala Lys Val Glu Lys Leu Arg
                1125                1130                1135    
Ser Asp Leu Ser Arg Glu Leu Glu Glu Ile Ser Glu Arg Leu Glu Glu
            1140                1145                1150        
Ala Gly Gly Ala Thr Ser Val Gln Ile Glu Met Asn Lys Lys Arg Glu
        1155                1160                1165            
Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu Ala Thr Leu Gln
    1170                1175                1180                
His Glu Ala Thr Ala Ala Ala Leu Arg Lys Lys His Ala Asp Ser Val
1185                1190                1195                1200
Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg Val Lys Gln Lys
                1205                1210                1215    
Leu Glu Lys Glu Lys Ser Glu Phe Lys Leu Glu Leu Asp Asp Val Thr
            1220                1225                1230        
Ser Asn Met Glu Gln Ile Ile Lys Ala Lys Ala Asn Leu Glu Lys Met
        1235                1240                1245            
Cys Arg Thr Leu Glu Asp Gln Met Asn Glu His Arg Ser Lys Ala Glu
    1250                1255                1260                
Glu Thr Gln Arg Ser Val Asn Asp Leu Thr Ser Gln Arg Ala Lys Leu
1265                1270                1275                1280
Gln Thr Glu Asn Gly Glu Leu Ser Arg Gln Leu Asp Glu Lys Glu Ala
                1285                1290                1295    
Leu Ile Ser Gln Leu Thr Arg Gly Lys Leu Thr Tyr Thr Gln Gln Leu
            1300                1305                1310        
Glu Asp Leu Lys Arg Gln Leu Glu Glu Glu Val Lys Ala Lys Asn Ala
        1315                1320                1325            
Leu Ala His Ala Leu Gln Ser Ala Arg His Asp Cys Asp Leu Leu Arg
    1330                1335                1340                
Glu Gln Tyr Glu Glu Glu Thr Glu Ala Lys Ala Glu Leu Gln Arg Val
1345                1350                1355                1360
Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg Thr Lys Tyr Glu
                1365                1370                1375    
Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu Ala Lys Lys Lys
            1380                1385                1390        
Leu Ala Gln Arg Leu Gln Glu Ala Glu Glu Ala Val Glu Ala Val Asn
        1395                1400                1405            
Ala Lys Cys Ser Ser Leu Glu Lys Thr Lys His Arg Leu Gln Asn Glu
    1410                1415                1420                
Ile Glu Asp Leu Met Val Asp Val Glu Arg Ser Asn Ala Ala Ala Ala
1425                1430                1435                1440
Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Ile Leu Ala Glu Trp
                1445                1450                1455    
Lys Gln Lys Tyr Glu Glu Ser Gln Ser Glu Leu Glu Ser Ser Gln Lys
            1460                1465                1470        
Glu Ala Arg Ser Leu Ser Thr Glu Leu Phe Lys Leu Lys Asn Ala Tyr
        1475                1480                1485            
Glu Glu Ser Leu Glu His Leu Glu Thr Phe Lys Arg Glu Asn Lys Asn
    1490                1495                1500                
Leu Gln Glu Glu Ile Ser Asp Leu Thr Glu Gln Leu Gly Ser Ser Gly
1505                1510                1515                1520
Lys Thr Ile His Glu Leu Glu Lys Val Arg Lys Gln Leu Glu Ala Glu
                1525                1530                1535    
Lys Met Glu Leu Gln Ser Ala Leu Glu Glu Ala Glu Ala Ser Leu Glu
            1540                1545                1550        
His Glu Glu Gly Lys Ile Leu Arg Ala Gln Leu Glu Phe Asn Gln Ile
        1555                1560                1565            
Lys Ala Glu Ile Glu Arg Lys Leu Ala Glu Lys Asp Glu Glu Met Glu
    1570                1575                1580                
Gln Ala Lys Arg Asn His Leu Arg Val Val Asp Ser Leu Gln Thr Ser
1585                1590                1595                1600
Leu Asp Ala Glu Thr Arg Ser Arg Asn Glu Ala Leu Arg Val Lys Lys
                1605                1610                1615    
Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln Leu Ser His Ala
            1620                1625                1630        
Asn Arg Met Ala Ala Glu Ala Gln Lys Gln Val Lys Ser Leu Gln Ser
        1635                1640                1645            
Leu Leu Lys Asp Thr Gln Ile Gln Leu Asp Asp Ala Val Arg Ala Asn
    1650                1655                1660                
Asp Asp Leu Lys Glu Asn Ile Ala Ile Val Glu Arg Arg Asn Asn Leu
1665                1670                1675                1680
Leu Gln Ala Glu Leu Glu Glu Leu Arg Ala Val Val Glu Gln Thr Glu
                1685                1690                1695    
Arg Ser Arg Lys Leu Ala Glu Gln Glu Leu Ile Glu Thr Ser Glu Arg
            1700                1705                1710        
Val Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile Asn Gln Lys Lys
        1715                1720                1725            
Lys Met Asp Ala Asp Leu Ser Gln Leu Gln Thr Glu Val Glu Glu Ala
    1730                1735                1740                
Val Gln Glu Cys Arg Asn Ala Glu Glu Lys Ala Lys Lys Ala Ile Thr
1745                1750                1755                1760
Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu Gln Asp Thr Ser
                1765                1770                1775    
Ala His Leu Glu Arg Met Lys Lys Asn Met Glu Gln Thr Ile Lys Asp
            1780                1785                1790        
Leu Gln His Arg Leu Asp Glu Ala Glu Gln Ile Ala Leu Lys Gly Gly
        1795                1800                1805            
Lys Lys Gln Leu Gln Lys Leu Glu Ala Arg Val Arg Glu Leu Glu Asn
    1810                1815                1820                
Glu Leu Glu Ala Glu Gln Lys Arg Asn Ala Glu Ser Val Lys Gly Met
1825                1830                1835                1840
Arg Lys Ser Glu Arg Arg Ile Lys Glu Leu Thr Tyr Gln Thr Glu Glu
                1845                1850                1855    
Asp Arg Lys Asn Leu Leu Arg Leu Gln Asp Leu Val Asp Lys Leu Gln
            1860                1865                1870        
Leu Lys Val Lys Ala Tyr Lys Arg Gln Ala Glu Glu Ala Glu Glu Gln
        1875                1880                1885            
Ala Asn Thr Asn Leu Ser Lys Phe Arg Lys Val Gln His Glu Leu Asp
    1890                1895                1900                
Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln Val Asn Lys Leu
1905                1910                1915                1920
Arg Ala Lys Ser Arg Asp Ile Gly Thr Lys Gly Leu Asn Glu Glu
                1925                1930                1935


<210> 5683
<211> 1939
<212> PRT
<213> Homo sapiens

<400> 5683
Met Thr Asp Ala Gln Met Ala Asp Phe Gly Ala Ala Ala Gln Tyr Leu
 1               5                  10                  15      
Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp
            20                  25                  30          
Ile Arg Thr Glu Cys Phe Val Pro Asp Asp Lys Glu Glu Phe Val Lys
        35                  40                  45              
Ala Lys Ile Leu Ser Arg Glu Gly Gly Lys Val Ile Ala Glu Thr Glu
    50                  55                  60                  
Asn Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Leu Gln Gln Asn
65                  70                  75                  80  
Pro Pro Lys Phe Asp Lys Ile Gln Asp Met Ala Met Leu Thr Phe Leu
                85                  90                  95      
His Glu Pro Ala Val Leu Phe Asn Leu Lys Glu Arg Tyr Ala Ala Trp
            100                 105                 110         
Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr
        115                 120                 125             
Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Ala Ala Tyr Arg Gly
    130                 135                 140                 
Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn
145                 150                 155                 160 
Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile
                165                 170                 175     
Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile
            180                 185                 190         
Gln Tyr Phe Ala Ser Ile Ala Ala Ile Gly Asp Arg Gly Lys Lys Asp
        195                 200                 205             
Asn Ala Asn Ala Asn Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala
    210                 215                 220                 
Asn Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp
225                 230                 235                 240 
Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr
                245                 250                 255     
Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser
            260                 265                 270         
Arg Val Ile Phe Gln Leu Lys Ala Glu Arg Asn Tyr His Ile Phe Tyr
        275                 280                 285             
Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Val
    290                 295                 300                 
Thr Asn Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu Val Ser
305                 310                 315                 320 
Val Ala Ser Ile Asp Asp Ser Glu Glu Leu Met Ala Thr Asp Ser Ala
                325                 330                 335     
Phe Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Ala Gly Val Tyr Lys
            340                 345                 350         
Leu Thr Gly Ala Ile Met His Tyr Gly Asn Met Lys Phe Lys Gln Lys
        355                 360                 365             
Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Asp Ala Asp Lys
    370                 375                 380                 
Ser Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu
385                 390                 395                 400 
Cys His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln
                405                 410                 415     
Ser Val Gln Gln Val Tyr Tyr Ser Ile Gly Ala Leu Ala Lys Ala Val
            420                 425                 430         
Tyr Glu Lys Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu
        435                 440                 445             
Glu Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala
    450                 455                 460                 
Gly Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn
465                 470                 475                 480 
Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val
                485                 490                 495     
Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile
            500                 505                 510         
Asp Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro
        515                 520                 525             
Met Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala
    530                 535                 540                 
Thr Asp Met Thr Phe Lys Ala Lys Leu Tyr Asp Asn His Leu Gly Lys
545                 550                 555                 560 
Ser Asn Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Gln Glu Ala
                565                 570                 575     
His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn Ile Leu
            580                 585                 590         
Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Ala
        595                 600                 605             
Leu Tyr Gln Lys Ser Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Ser
    610                 615                 620                 
Tyr Ala Thr Ala Asp Thr Gly Asp Ser Gly Lys Ser Lys Gly Gly Lys
625                 630                 635                 640 
Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn
                645                 650                 655     
Leu Asn Lys Leu Met Thr Asn Leu Arg Thr Thr His Pro His Phe Val
            660                 665                 670         
Arg Cys Ile Ile Pro Asn Glu Arg Lys Ala Pro Gly Val Met Asp Asn
        675                 680                 685             
Pro Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile
    690                 695                 700                 
Arg Ile Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe
705                 710                 715                 720 
Arg Gln Arg Tyr Arg Ile Leu Asn Pro Val Ala Ile Pro Glu Gly Gln
                725                 730                 735     
Phe Ile Asp Ser Arg Lys Gly Thr Glu Lys Leu Leu Ser Ser Leu Asp
            740                 745                 750         
Ile Asp His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys
        755                 760                 765             
Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser
    770                 775                 780                 
Arg Ile Ile Thr Arg Met Gln Ala Gln Ala Arg Gly Gln Leu Met Arg
785                 790                 795                 800 
Ile Glu Phe Lys Lys Ile Val Glu Arg Arg Asp Ala Leu Leu Val Ile
                805                 810                 815     
Gln Trp Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met
            820                 825                 830         
Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu
        835                 840                 845             
Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gly Arg Ile Lys Glu Thr
    850                 855                 860                 
Leu Glu Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val
865                 870                 875                 880 
Ser Leu Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu
                885                 890                 895     
Gln Asp Asn Leu Asn Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys
            900                 905                 910         
Asn Lys Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu
        915                 920                 925             
Glu Asp Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys
    930                 935                 940                 
Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu
945                 950                 955                 960 
Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys
                965                 970                 975     
Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala
            980                 985                 990         
Lys Leu Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala His Gln Gln Ala
        995                 1000                1005            
Leu Asp Asp Leu Gln Val Glu Glu Asp Lys Val Asn Ser Leu Ser Lys
    1010                1015                1020                
Ser Lys Val Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly Ser Leu
1025                1030                1035                1040
Glu Gln Glu Lys Lys Val Arg Met Asp Leu Glu Arg Ala Lys Arg Lys
                1045                1050                1055    
Leu Glu Gly Asp Leu Lys Leu Thr Gln Glu Ser Ile Met Asp Leu Glu
            1060                1065                1070        
Asn Asp Lys Leu Gln Leu Glu Glu Lys Leu Lys Lys Lys Glu Phe Asp
        1075                1080                1085            
Ile Asn Gln Gln Asn Ser Lys Ile Glu Asp Glu Gln Ala Leu Ala Leu
    1090                1095                1100                
Gln Leu Gln Lys Lys Leu Lys Glu Asn Gln Ala Arg Ile Glu Glu Leu
1105                1110                1115                1120
Glu Glu Glu Leu Glu Ala Glu Arg Thr Ala Arg Ala Lys Val Glu Lys
                1125                1130                1135    
Leu Arg Ser Asp Leu Ser Arg Glu Leu Glu Glu Ile Ser Glu Arg Leu
            1140                1145                1150        
Glu Glu Ala Gly Gly Ala Thr Ser Val Gln Ile Glu Met Asn Lys Lys
        1155                1160                1165            
Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu Ala Thr
    1170                1175                1180                
Leu Gln His Glu Ala Thr Ala Ala Ala Leu Arg Lys Lys His Ala Asp
1185                1190                1195                1200
Ser Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg Val Lys
                1205                1210                1215    
Gln Lys Leu Glu Lys Glu Lys Ser Glu Phe Lys Leu Glu Leu Asp Asp
            1220                1225                1230        
Val Thr Ser Asn Met Glu Gln Ile Ile Lys Ala Lys Ala Asn Leu Glu
        1235                1240                1245            
Lys Val Ser Arg Thr Leu Glu Asp Gln Ala Asn Glu Tyr Arg Val Lys
    1250                1255                1260                
Leu Glu Glu Ala Gln Arg Ser Leu Asn Asp Phe Thr Thr Gln Arg Ala
1265                1270                1275                1280
Lys Leu Gln Thr Glu Asn Gly Glu Leu Ala Arg Gln Leu Glu Glu Lys
                1285                1290                1295    
Glu Ala Leu Ile Ser Gln Leu Thr Arg Gly Lys Leu Ser Tyr Thr Gln
            1300                1305                1310        
Gln Met Glu Asp Leu Lys Arg Gln Leu Glu Glu Glu Gly Lys Ala Lys
        1315                1320                1325            
Asn Ala Leu Ala His Ala Leu Gln Ser Ala Arg His Asp Cys Asp Leu
    1330                1335                1340                
Leu Arg Glu Gln Tyr Glu Glu Glu Thr Glu Ala Lys Ala Glu Leu Gln
1345                1350                1355                1360
Arg Val Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg Thr Lys
                1365                1370                1375    
Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu Ala Lys
            1380                1385                1390        
Lys Lys Leu Ala Gln Arg Leu Gln Asp Ala Glu Glu Ala Val Glu Ala
        1395                1400                1405            
Val Asn Ala Lys Cys Ser Ser Leu Glu Lys Thr Lys His Arg Leu Gln
    1410                1415                1420                
Asn Glu Ile Glu Asp Leu Met Val Asp Val Glu Arg Ser Asn Ala Ala
1425                1430                1435                1440
Ala Ala Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Ile Leu Ala
                1445                1450                1455    
Glu Trp Lys Gln Lys Tyr Glu Glu Ser Gln Ser Glu Leu Glu Ser Ser
            1460                1465                1470        
Gln Lys Glu Ala Arg Ser Leu Ser Thr Glu Leu Phe Lys Leu Lys Asn
        1475                1480                1485            
Ala Tyr Glu Glu Ser Leu Glu His Leu Glu Thr Phe Lys Arg Glu Asn
    1490                1495                1500                
Lys Asn Leu Gln Glu Glu Ile Ser Asp Leu Thr Glu Gln Leu Gly Glu
1505                1510                1515                1520
Gly Gly Lys Asn Val His Glu Leu Glu Lys Val Arg Lys Gln Leu Glu
                1525                1530                1535    
Val Glu Lys Leu Glu Leu Gln Ser Ala Leu Glu Glu Ala Glu Ala Ser
            1540                1545                1550        
Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ala Gln Leu Glu Phe Asn
        1555                1560                1565            
Gln Ile Lys Ala Glu Ile Glu Arg Lys Leu Ala Glu Lys Asp Glu Glu
    1570                1575                1580                
Met Glu Gln Ala Lys Arg Asn His Gln Arg Val Val Asp Ser Leu Gln
1585                1590                1595                1600
Thr Ser Leu Asp Ala Glu Thr Arg Ser Arg Asn Glu Val Leu Arg Val
                1605                1610                1615    
Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln Leu Ser
            1620                1625                1630        
His Ala Asn Arg Met Ala Ala Glu Ala Gln Lys Gln Val Lys Ser Leu
        1635                1640                1645            
Gln Ser Leu Leu Lys Asp Thr Gln Ile Gln Leu Asp Asp Ala Val Arg
    1650                1655                1660                
Ala Asn Asp Asp Leu Lys Glu Asn Ile Ala Ile Val Glu Arg Arg Asn
1665                1670                1675                1680
Asn Leu Leu Gln Ala Glu Leu Glu Glu Leu Arg Ala Val Val Glu Gln
                1685                1690                1695    
Thr Glu Arg Ser Arg Lys Leu Ala Glu Gln Glu Leu Ile Glu Thr Ser
            1700                1705                1710        
Glu Arg Val Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile Asn Gln
        1715                1720                1725            
Lys Lys Lys Met Glu Ala Asp Leu Thr Gln Leu Gln Ser Glu Val Glu
    1730                1735                1740                
Glu Ala Val Gln Glu Cys Arg Asn Ala Glu Glu Lys Ala Lys Lys Ala
1745                1750                1755                1760
Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu Gln Asp
                1765                1770                1775    
Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Met Glu Gln Thr Ile
            1780                1785                1790        
Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Ile Ala Leu Lys
        1795                1800                1805            
Gly Gly Lys Lys Gln Leu Gln Lys Leu Glu Ala Arg Val Arg Glu Leu
    1810                1815                1820                
Glu Gly Glu Leu Glu Ala Glu Gln Lys Arg Asn Ala Glu Ser Val Lys
1825                1830                1835                1840
Gly Met Arg Lys Ser Glu Arg Arg Ile Lys Glu Leu Thr Tyr Gln Thr
                1845                1850                1855    
Glu Glu Asp Lys Lys Asn Leu Leu Arg Leu Gln Asp Leu Val Asp Lys
            1860                1865                1870        
Leu Gln Leu Lys Val Lys Ala Tyr Lys Arg Gln Ala Glu Glu Ala Glu
        1875                1880                1885            
Glu Gln Ala Asn Thr Asn Leu Ser Lys Phe Arg Lys Val Gln His Glu
    1890                1895                1900                
Leu Asp Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln Val Asn
1905                1910                1915                1920
Lys Leu Arg Ala Lys Ser Arg Asp Ile Gly Ala Lys Gln Lys Met His
                1925                1930                1935    
Asp Glu Glu
            


<210> 5684
<211> 1941
<212> PRT
<213> Homo sapiens

<400> 5684
Met Ser Ser Asp Ser Glu Leu Ala Val Phe Gly Glu Ala Ala Pro Phe
 1               5                  10                  15      
Leu Arg Lys Ser Glu Arg Glu Arg Ile Glu Ala Gln Asn Arg Pro Phe
            20                  25                  30          
Asp Ala Lys Thr Ser Val Phe Val Ala Glu Pro Lys Glu Ser Phe Val
        35                  40                  45              
Lys Gly Thr Ile Gln Ser Arg Glu Gly Gly Lys Val Thr Val Lys Thr
    50                  55                  60                  
Glu Gly Gly Ala Thr Leu Thr Val Lys Asp Asp Gln Val Phe Pro Met
65                  70                  75                  80  
Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His
                85                  90                  95      
Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Thr Ala Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu
        195                 200                 205             
Glu Ile Thr Ser Gly Lys Ile Gln Gly Thr Leu Glu Asp Gln Ile Ile
    210                 215                 220                 
Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg
225                 230                 235                 240 
Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly
                245                 250                 255     
Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu
            260                 265                 270         
Lys Ser Arg Val Val Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile
        275                 280                 285             
Phe Tyr Gln Ile Thr Ser Asn Lys Lys Pro Glu Leu Ile Glu Met Leu
    290                 295                 300                 
Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Pro Phe Val Ser Gln Gly Glu
305                 310                 315                 320 
Ile Ser Val Ala Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp
                325                 330                 335     
Ser Ala Ile Asp Ile Leu Gly Phe Thr Asn Glu Glu Lys Val Ser Ile
            340                 345                 350         
Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Leu Lys Phe Lys
        355                 360                 365             
Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala
    370                 375                 380                 
Asp Lys Ala Ala Tyr Leu Gln Ser Leu Asn Ser Ala Asp Leu Leu Lys
385                 390                 395                 400 
Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys
                405                 410                 415     
Gly Gln Thr Val Glu Gln Val Ser Asn Ala Val Gly Ala Leu Ala Lys
            420                 425                 430         
Ala Val Tyr Glu Lys Met Phe Leu Trp Met Val Ala Arg Ile Asn Gln
        435                 440                 445             
Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp
    450                 455                 460                 
Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys
465                 470                 475                 480 
Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met
                485                 490                 495     
Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr
            500                 505                 510         
Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu
        515                 520                 525             
Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro
    530                 535                 540                 
Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu
545                 550                 555                 560 
Gly Lys Ser Ala Asn Phe Gln Lys Pro Lys Val Val Lys Gly Lys Ala
                565                 570                 575     
Glu Ala His Phe Ala Leu Ile His Tyr Ala Gly Val Val Asp Tyr Asn
            580                 585                 590         
Ile Thr Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val
        595                 600                 605             
Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Gln Leu Phe
    610                 615                 620                 
Ser Gly Ala Gln Thr Ala Glu Gly Glu Gly Ala Gly Gly Gly Ala Lys
625                 630                 635                 640 
Lys Gly Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu
                645                 650                 655     
Phe Arg Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His
            660                 665                 670         
Pro His Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly
        675                 680                 685             
Ala Met Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val
    690                 695                 700                 
Leu Glu Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu
705                 710                 715                 720 
Tyr Ala Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile
                725                 730                 735     
Pro Glu Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu
            740                 745                 750         
Ala Ser Ile Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys
        755                 760                 765             
Val Phe Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp
    770                 775                 780                 
Asp Lys Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Arg Cys Arg Gly
785                 790                 795                 800 
Phe Leu Ala Arg Val Glu Tyr Gln Arg Met Val Glu Arg Arg Glu Ala
                805                 810                 815     
Ile Phe Cys Ile Gln Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His
            820                 825                 830         
Trp Pro Trp Met Lys Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser
        835                 840                 845             
Ala Glu Thr Glu Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys
    850                 855                 860                 
Ile Lys Asp Glu Leu Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu
865                 870                 875                 880 
Glu Lys Met Val Thr Leu Leu Lys Glu Lys Asn Asp Leu Gln Leu Gln
                885                 890                 895     
Val Gln Ala Glu Ala Glu Gly Leu Ala Asp Ala Glu Glu Arg Cys Asp
            900                 905                 910         
Gln Leu Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val
        915                 920                 925             
Thr Glu Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala
    930                 935                 940                 
Lys Lys Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile
945                 950                 955                 960 
Asp Asp Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala
                965                 970                 975     
Thr Glu Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp
            980                 985                 990         
Glu Thr Ile Ala Lys Leu Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala
        995                 1000                1005            
His Gln Gln Thr Leu Asp Asp Leu Gln Ala Glu Glu Asp Lys Val Asn
    1010                1015                1020                
Thr Leu Thr Lys Ala Lys Ile Lys Leu Glu Gln Gln Val Asp Asp Leu
1025                1030                1035                1040
Glu Gly Ser Leu Glu Gln Glu Lys Lys Leu Arg Met Asp Leu Glu Arg
                1045                1050                1055    
Ala Lys Arg Lys Leu Glu Gly Asp Leu Lys Leu Ala Gln Glu Ser Ile
            1060                1065                1070        
Met Asp Ile Glu Asn Glu Lys Gln Gln Leu Asp Glu Lys Leu Lys Lys
        1075                1080                1085            
Lys Glu Phe Glu Ile Ser Asn Leu Gln Ser Lys Ile Glu Asp Glu Gln
    1090                1095                1100                
Ala Leu Gly Ile Gln Leu Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg
1105                1110                1115                1120
Ile Glu Glu Leu Glu Glu Glu Ile Glu Ala Glu Arg Ala Ser Arg Ala
                1125                1130                1135    
Lys Ala Glu Lys Gln Arg Ser Asp Leu Ser Arg Glu Leu Glu Glu Ile
            1140                1145                1150        
Ser Glu Arg Leu Glu Glu Ala Gly Gly Ala Thr Ser Ala Gln Ile Glu
        1155                1160                1165            
Met Asn Lys Lys Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu
    1170                1175                1180                
Glu Glu Ala Thr Leu Gln His Glu Ala Thr Ala Ala Thr Leu Arg Lys
1185                1190                1195                1200
Lys His Ala Asp Ser Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu
                1205                1210                1215    
Gln Arg Val Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Met Lys Met
            1220                1225                1230        
Glu Ile Asp Asp Leu Ala Ser Asn Val Glu Thr Val Ser Lys Ala Lys
        1235                1240                1245            
Gly Asn Leu Glu Lys Met Cys Arg Thr Leu Glu Asp Gln Leu Ser Glu
    1250                1255                1260                
Leu Lys Ser Lys Glu Glu Glu Gln Gln Arg Leu Ile Asn Asp Leu Thr
1265                1270                1275                1280
Ala Gln Arg Gly Arg Leu Gln Thr Glu Ser Gly Glu Phe Ser Arg Gln
                1285                1290                1295    
Leu Asp Glu Lys Glu Ala Leu Val Ser Gln Leu Ser Arg Gly Lys Gln
            1300                1305                1310        
Ala Phe Thr Gln Gln Ile Glu Glu Leu Lys Arg Gln Leu Glu Glu Glu
        1315                1320                1325            
Ile Lys Ala Lys Asn Ala Leu Ala His Ala Leu Gln Ser Ser Arg His
    1330                1335                1340                
Asp Cys Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Ser Lys
1345                1350                1355                1360
Ala Glu Leu Gln Arg Ala Leu Ser Lys Ala Asn Thr Glu Val Ala Gln
                1365                1370                1375    
Trp Arg Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu
            1380                1385                1390        
Glu Glu Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln Ala Ala Glu Glu
        1395                1400                1405            
His Val Glu Ala Val Asn Ala Lys Cys Ala Ser Leu Glu Lys Thr Lys
    1410                1415                1420                
Gln Arg Leu Gln Asn Glu Val Glu Asp Leu Met Leu Asp Val Glu Arg
1425                1430                1435                1440
Thr Asn Ala Ala Cys Ala Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp
                1445                1450                1455    
Lys Ile Leu Ala Glu Trp Lys Gln Lys Cys Glu Glu Thr His Ala Glu
            1460                1465                1470        
Leu Glu Ala Ser Gln Lys Glu Ala Arg Ser Leu Gly Thr Glu Leu Phe
        1475                1480                1485            
Lys Ile Lys Asn Ala Tyr Glu Glu Ser Leu Asp Gln Leu Glu Thr Leu
    1490                1495                1500                
Lys Arg Glu Asn Lys Asn Leu Gln Gln Glu Ile Ser Asp Leu Thr Glu
1505                1510                1515                1520
Gln Ile Ala Glu Gly Gly Lys Arg Ile His Glu Leu Glu Lys Ile Lys
                1525                1530                1535    
Lys Gln Val Glu Gln Glu Lys Cys Glu Leu Gln Ala Ala Leu Glu Glu
            1540                1545                1550        
Ala Glu Ala Ser Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ile Gln
        1555                1560                1565            
Leu Glu Leu Asn Gln Val Lys Ser Glu Val Asp Arg Lys Ile Ala Glu
    1570                1575                1580                
Lys Asp Glu Glu Ile Asp Gln Leu Lys Arg Asn His Ile Arg Ile Val
1585                1590                1595                1600
Glu Ser Met Gln Ser Thr Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp
                1605                1610                1615    
Ala Ile Arg Leu Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu
            1620                1625                1630        
Ile Gln Leu Asn His Ala Asn Arg Met Ala Ala Glu Ala Leu Arg Asn
        1635                1640                1645            
Tyr Arg Asn Thr Gln Gly Ile Leu Lys Asp Thr Gln Ile His Leu Asp
    1650                1655                1660                
Asp Ala Leu Arg Ser Gln Glu Asp Leu Lys Glu Gln Leu Ala Met Val
1665                1670                1675                1680
Glu Arg Arg Ala Asn Leu Leu Gln Ala Glu Ile Glu Glu Leu Arg Ala
                1685                1690                1695    
Thr Leu Glu Gln Thr Glu Arg Ser Arg Lys Ile Ala Glu Gln Glu Leu
            1700                1705                1710        
Leu Asp Ala Ser Glu Arg Val Gln Leu Leu His Thr Gln Asn Thr Ser
        1715                1720                1725            
Leu Ile Asn Thr Lys Lys Lys Leu Glu Thr Asp Ile Ser Gln Met Gln
    1730                1735                1740                
Gly Glu Met Glu Asp Ile Leu Gln Glu Ala Arg Asn Ala Glu Glu Lys
1745                1750                1755                1760
Ala Lys Lys Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys
                1765                1770                1775    
Lys Glu Gln Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Met
            1780                1785                1790        
Glu Gln Thr Val Lys Asp Leu Gln Leu Arg Leu Asp Glu Ala Glu Gln
        1795                1800                1805            
Leu Ala Leu Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Ala Arg
    1810                1815                1820                
Val Arg Glu Leu Glu Gly Glu Val Glu Ser Glu Gln Lys Arg Asn Ala
1825                1830                1835                1840
Glu Ala Val Lys Gly Leu Arg Lys His Glu Arg Arg Val Lys Glu Leu
                1845                1850                1855    
Thr Tyr Gln Thr Glu Glu Asp Arg Lys Asn Ile Leu Arg Leu Gln Asp
            1860                1865                1870        
Leu Val Asp Lys Leu Gln Ala Lys Val Lys Ser Tyr Lys Arg Gln Ala
        1875                1880                1885            
Glu Glu Ala Glu Glu Gln Ser Asn Thr Asn Leu Ala Lys Phe Arg Lys
    1890                1895                1900                
Leu Gln His Glu Leu Glu Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu
1905                1910                1915                1920
Ser Gln Val Asn Lys Leu Arg Val Lys Ser Arg Glu Val His Thr Lys
                1925                1930                1935    
Val Ile Ser Glu Glu
            1940    


<210> 5685
<211> 1939
<212> PRT
<213> Homo sapiens

<400> 5685
Met Ser Ser Asp Ser Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Phe
 1               5                  10                  15      
Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Lys Pro Phe
            20                  25                  30          
Asp Ala Lys Thr Ser Val Phe Val Val Asp Pro Lys Glu Ser Tyr Val
        35                  40                  45              
Lys Ala Ile Val Gln Ser Arg Glu Gly Gly Lys Val Thr Ala Lys Thr
    50                  55                  60                  
Glu Ala Gly Ala Thr Val Thr Val Lys Glu Asp Gln Val Phe Ser Met
65                  70                  75                  80  
Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His
                85                  90                  95      
Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Asn Pro Glu Val Val Thr Ala Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu
        195                 200                 205             
Glu Pro Ala Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile
    210                 215                 220                 
Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg
225                 230                 235                 240 
Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly
                245                 250                 255     
Ala Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu
            260                 265                 270         
Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile
        275                 280                 285             
Phe Tyr Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Ile Glu Met Leu
    290                 295                 300                 
Leu Ile Thr Thr Asn Pro Tyr Asp Phe Ala Phe Val Ser Gln Gly Glu
305                 310                 315                 320 
Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp
                325                 330                 335     
Ser Ala Val Asp Ile Leu Gly Phe Thr Ala Asp Glu Lys Val Ala Ile
            340                 345                 350         
Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys
        355                 360                 365             
Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala
    370                 375                 380                 
Asp Lys Ala Ala Tyr Leu Thr Ser Leu Asn Ser Ala Asp Leu Leu Lys
385                 390                 395                 400 
Ser Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Phe Val Thr Lys
                405                 410                 415     
Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys
            420                 425                 430         
Ala Ile Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln
        435                 440                 445             
Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp
    450                 455                 460                 
Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys
465                 470                 475                 480 
Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met
                485                 490                 495     
Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Glu
            500                 505                 510         
Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu
        515                 520                 525             
Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro
    530                 535                 540                 
Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Glu Gln His Leu
545                 550                 555                 560 
Gly Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Pro
                565                 570                 575     
Glu Ala His Phe Ser Leu Val His Tyr Ala Gly Thr Val Asp Tyr Asn
            580                 585                 590         
Ile Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val
        595                 600                 605             
Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Phe Leu Phe
    610                 615                 620                 
Ser Gly Ala Gln Thr Ala Glu Ala Glu Gly Gly Gly Gly Lys Lys Gly
625                 630                 635                 640 
Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg
                645                 650                 655     
Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His
            660                 665                 670         
Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met
        675                 680                 685             
Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu
    690                 695                 700                 
Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala
705                 710                 715                 720 
Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu
                725                 730                 735     
Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Gly Ser
            740                 745                 750         
Ile Glu Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe
        755                 760                 765             
Phe Lys Ala Gly Leu Leu Gly Thr Leu Glu Glu Met Arg Asp Glu Lys
    770                 775                 780                 
Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Ile Cys Arg Gly Phe Leu
785                 790                 795                 800 
Met Arg Val Glu Phe Arg Lys Met Met Glu Arg Arg Glu Ser Ile Phe
                805                 810                 815     
Cys Ile Gln Tyr Asn Ile Arg Ala Phe Met Asn Val Lys His Trp Pro
            820                 825                 830         
Trp Met Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu
        835                 840                 845             
Thr Glu Lys Glu Met Ala Asn Met Lys Glu Glu Phe Glu Lys Thr Lys
    850                 855                 860                 
Glu Glu Leu Ala Lys Thr Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys
865                 870                 875                 880 
Met Val Thr Leu Met Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln
                885                 890                 895     
Ala Glu Ala Asp Ala Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu
            900                 905                 910         
Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu
        915                 920                 925             
Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys
    930                 935                 940                 
Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp
945                 950                 955                 960 
Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu
                965                 970                 975     
Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr
            980                 985                 990         
Ile Ala Lys Leu Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala His Gln
        995                 1000                1005            
Gln Thr Leu Asp Asp Leu Gln Met Glu Glu Asp Lys Val Asn Thr Leu
    1010                1015                1020                
Thr Lys Ala Lys Thr Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly
1025                1030                1035                1040
Ser Leu Glu Gln Glu Lys Lys Leu Cys Met Asp Leu Glu Arg Ala Lys
                1045                1050                1055    
Arg Lys Leu Glu Gly Asp Leu Lys Leu Ala Gln Glu Ser Thr Met Asp
            1060                1065                1070        
Thr Glu Asn Asp Lys Gln Gln Leu Asn Glu Lys Leu Lys Lys Lys Glu
        1075                1080                1085            
Phe Glu Met Ser Asn Leu Gln Gly Lys Ile Glu Asp Glu Gln Ala Leu
    1090                1095                1100                
Ala Met Gln Leu Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu
1105                1110                1115                1120
Glu Leu Glu Glu Glu Ile Glu Ala Glu Arg Ala Ser Arg Ala Lys Ala
                1125                1130                1135    
Glu Lys Gln Arg Ser Asp Leu Ser Arg Glu Leu Glu Glu Ile Ser Glu
            1140                1145                1150        
Arg Leu Glu Glu Ala Gly Gly Ala Thr Ser Ala Gln Ile Glu Leu Asn
        1155                1160                1165            
Lys Lys Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu
    1170                1175                1180                
Ser Thr Leu Gln His Glu Ala Thr Ala Ala Ala Leu Arg Lys Lys His
1185                1190                1195                1200
Ala Asp Ser Val Ala Glu Leu Gly Lys Gln Ile Asp Ser Leu Gln Arg
                1205                1210                1215    
Val Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Leu Lys Met Glu Ile
            1220                1225                1230        
Asn Asp Leu Ala Ser Asn Met Glu Thr Val Ser Lys Ala Lys Ala Asn
        1235                1240                1245            
Phe Glu Lys Met Cys Arg Thr Leu Glu Asp Gln Leu Ser Glu Ile Lys
    1250                1255                1260                
Thr Lys Glu Glu Glu Gln Gln Arg Leu Ile Asn Glu Leu Ser Ala Gln
1265                1270                1275                1280
Lys Ala Arg Leu His Thr Glu Ser Gly Glu Phe Ser Arg Gln Leu Asp
                1285                1290                1295    
Glu Lys Asp Ala Met Val Ser Gln Leu Ser Arg Gly Lys Gln Ala Phe
            1300                1305                1310        
Thr Gln Gln Ile Glu Glu Leu Lys Arg Gln Leu Glu Glu Glu Thr Lys
        1315                1320                1325            
Ala Lys Ser Thr Leu Ala His Ala Leu Gln Ser Ala Arg His Asp Cys
    1330                1335                1340                
Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Ala Lys Ala Glu
1345                1350                1355                1360
Leu Gln Arg Gly Met Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg
                1365                1370                1375    
Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu
            1380                1385                1390        
Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln Asp Ala Glu Glu His Val
        1395                1400                1405            
Glu Ala Val Asn Ser Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg
    1410                1415                1420                
Leu Gln Asn Glu Val Glu Asp Leu Met Ile Asp Val Glu Arg Ser Asn
1425                1430                1435                1440
Ala Ala Cys Ile Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Val
                1445                1450                1455    
Leu Ala Glu Trp Lys Gln Lys Tyr Glu Glu Thr Gln Ala Glu Leu Glu
            1460                1465                1470        
Ala Ser Gln Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Val
        1475                1480                1485            
Lys Asn Ala Tyr Glu Glu Ser Leu Asp His Leu Glu Thr Leu Lys Arg
    1490                1495                1500                
Glu Asn Lys Asn Leu Gln Gln Glu Ile Ser Asp Leu Thr Glu Gln Ile
1505                1510                1515                1520
Ala Glu Gly Gly Lys His Ile His Glu Leu Glu Lys Val Lys Lys Gln
                1525                1530                1535    
Leu Asp His Glu Lys Ser Glu Leu Gln Thr Ser Leu Glu Glu Ala Glu
            1540                1545                1550        
Ala Ser Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ile Gln Leu Glu
        1555                1560                1565            
Leu Asn Gln Val Lys Ser Glu Ile Asp Arg Lys Ile Ala Glu Lys Asp
    1570                1575                1580                
Glu Glu Leu Asp Gln Leu Lys Arg Asn His Leu Arg Val Val Glu Ser
1585                1590                1595                1600
Met Gln Ser Thr Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp Ala Leu
                1605                1610                1615    
Arg Ile Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln
            1620                1625                1630        
Leu Asn His Ala Asn Arg Gln Ala Ala Glu Ala Leu Arg Asn Leu Arg
        1635                1640                1645            
Asn Thr Gln Gly Ile Leu Lys Asp Thr Gln Leu His Leu Asp Asp Ala
    1650                1655                1660                
Ile Arg Gly Gln Asp Asp Leu Lys Glu Gln Leu Ala Met Val Glu Arg
1665                1670                1675                1680
Arg Ala Asn Leu Met Gln Ala Glu Val Glu Glu Leu Arg Ala Ser Leu
                1685                1690                1695    
Glu Arg Thr Glu Arg Gly Arg Lys Met Ala Glu Gln Glu Leu Leu Asp
            1700                1705                1710        
Ala Ser Glu Arg Val Gln Leu Leu His Thr Gln Asn Thr Ser Leu Ile
        1715                1720                1725            
Asn Thr Lys Lys Lys Leu Glu Thr Asp Ile Ser Gln Ile Gln Gly Glu
    1730                1735                1740                
Met Glu Asp Ile Val Gln Glu Ala Arg Asn Ala Glu Glu Lys Ala Lys
1745                1750                1755                1760
Lys Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu
                1765                1770                1775    
Gln Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Met Glu Gln
            1780                1785                1790        
Thr Val Lys Asp Leu Gln Leu Arg Leu Gly Glu Ala Glu Gln Leu Ala
        1795                1800                1805            
Leu Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Ala Arg Val Arg
    1810                1815                1820                
Glu Leu Glu Ser Glu Val Glu Ser Glu Gln Lys His Asn Val Glu Ala
1825                1830                1835                1840
Val Lys Gly Leu Arg Lys His Glu Arg Arg Val Lys Glu Leu Thr Tyr
                1845                1850                1855    
Gln Thr Glu Glu Asp Arg Lys Asn Ile Leu Arg Leu Gln Asp Leu Val
            1860                1865                1870        
Asp Lys Leu Gln Thr Lys Val Lys Ala Tyr Lys Arg Gln Ala Glu Glu
        1875                1880                1885            
Ala Glu Glu Gln Ser Asn Val Asn Leu Ala Lys Phe Arg Lys Leu Gln
    1890                1895                1900                
His Glu Leu Glu Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln
1905                1910                1915                1920
Val Asn Lys Leu Arg Val Lys Ser Arg Glu Val His Thr Lys Val Ile
                1925                1930                1935    
Ser Glu Glu
            


<210> 5686
<211> 742
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 33, 64, 228, 293, 295, 349, 606
<223> Xaa = Any Amino Acid

<400> 5686
Met Asn Gln Gln Gln Gln Gln Gln Gln Lys Val Gly Lys Gln Gln Leu
 1               5                  10                  15      
Ser Glu Pro Glu Asp Val Glu Met Glu Ala Gly Asp Thr Asp Asp Pro
            20                  25                  30          
Xaa Arg Ile Thr Gln Asn Ala Val Ile Asn Gly Asn Val Ala Leu Arg
        35                  40                  45              
Asp Gly His Asn Asn Lys Glu Glu Gly Met Glu Asp Glu Thr Ser Xaa
    50                  55                  60                  
Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Leu Phe Ser Arg Leu
65                  70                  75                  80  
Ser Glu Ser Val Ile Ser Pro Pro Cys Phe Val Arg Asn Leu Pro Trp
                85                  90                  95      
Lys Ile Met Val Val Pro Arg Phe Tyr Pro Glu Arg Pro His Gln Lys
            100                 105                 110         
Ser Val Gly Phe Phe Leu Gln Ser Asn Ala Glu Ser Asp Ser Thr Ser
        115                 120                 125             
Arg Thr Cys His Ala Gln Ala Met Leu Lys Ile Ile Asn Tyr Gly Asp
    130                 135                 140                 
Asp Gly Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His Lys
145                 150                 155                 160 
Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val Thr
                165                 170                 175     
Asp Pro Glu Lys Gly Phe Ile Glu Asp Asp Lys Asn Gln Arg Ala Ile
            180                 185                 190         
Cys Tyr Ile Asn Ser Leu Leu Gln Thr Phe Phe Phe Thr Asn Gln Leu
        195                 200                 205             
Arg Lys Ser Val Tyr Met Met Gln Thr Glu Gly Asp Asp Ser Ser Lys
    210                 215                 220                 
Ser Val Pro Xaa Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln Arg Ser
225                 230                 235                 240 
Asp Lys Pro Val Gly Lys Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu
                245                 250                 255     
Ile Leu Asp Ser Phe Met Gln His Asp Val Gln Gln Leu Cys Gly Val
            260                 265                 270         
Leu Leu Asp Asn Val Glu Lys Lys Val Lys Gly Thr Cys Val Glu Gly
        275                 280                 285             
Thr Ile Pro Arg Xaa Phe Xaa Gly Lys Met Val Ser Tyr Ile Gln Arg
    290                 295                 300                 
Lys Glu Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile
305                 310                 315                 320 
Gln Leu Ser Ile Glu Gly Asn Lys Asn Ile Phe Glu Ser Phe Val Asn
                325                 330                 335     
Tyr Met Ala Glu Glu Gln Leu Ser Gly Asp Asn Lys Xaa Glu Ala Gly
            340                 345                 350         
Glu His Gly Ser Gln Glu Ala Glu Lys Val Leu Val His Ser Arg Asp
        355                 360                 365             
Asn His Gly Arg His Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly
    370                 375                 380                 
Lys Trp Cys Lys Phe Asp Asp Asp Val Val Ser Ser Trp Trp Asn Asp
385                 390                 395                 400 
Ser Lys Lys Arg Lys Gly Ser Thr Leu Arg Arg Trp Thr Glu Trp Gln
                405                 410                 415     
Glu Val His Leu Tyr Met Gln Ala Gln Val Ala Ser Glu Asp Gln Phe
            420                 425                 430         
Cys Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr
        435                 440                 445             
Thr Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln
    450                 455                 460                 
Asn Leu Ser Gln Ile Met Glu Phe Pro Gln Asp Gln Ile Gln Leu Trp
465                 470                 475                 480 
Pro Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp
                485                 490                 495     
Asn Glu Ala Asp Gly Asn Lys Ala Met Ile Glu Val Ser Asp Asn Glu
            500                 505                 510         
Asn Ser Trp Thr Ile Phe Leu Glu Thr Val Asp Leu Glu Leu Ala Ala
        515                 520                 525             
Ser Gly Val Thr Leu Pro Lys Phe Asp Lys Ala His Asp Val Met Phe
    530                 535                 540                 
Phe Leu Lys Met Tyr Asp Pro Lys Met Arg Ser Leu Asn Tyr Cys Gly
545                 550                 555                 560 
His Ile Tyr Thr Pro Ile Ser Cys Glu Ile Arg Asp Leu Leu Pro Val
                565                 570                 575     
Met Cys Asn Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr
            580                 585                 590         
Glu Glu Val Lys Leu Asn Leu Thr Glu Arg Ile Gln Asp Xaa Asp Val
        595                 600                 605             
Ser Leu Glu Lys Ala Leu Asp Glu Leu Met Asp Gly Pro Asn Leu Ser
    610                 615                 620                 
Gln Ser His Ser Ser Pro Trp Arg Lys Lys Phe His Phe Leu Pro Cys
625                 630                 635                 640 
Lys Asn Leu Val Met Gly Lys Cys Arg Asp Glu Arg Ala Leu Arg Glu
                645                 650                 655     
His Phe Glu Arg Thr Leu Trp Arg Arg Lys Ser Trp Glu Pro Leu Ser
            660                 665                 670         
His Gly Ile Asp Gln Glu Ser Phe Val Ala Lys Leu Asn Gly Lys Val
        675                 680                 685             
Arg Thr Leu Gln Glu Ala Cys Val Thr Glu Leu Ala Gly Thr Asp Ala
    690                 695                 700                 
Asp Ile Thr Ser His His Lys Phe Gln His Ile Gln Ser Lys Asp Glu
705                 710                 715                 720 
Gln Val Leu Gly Ala Gly Val Glu Arg Gly Gln Ser Cys Ser Cys Arg
                725                 730                 735     
Arg Gln Lys Val Val Leu
            740         


<210> 5687
<211> 285
<212> PRT
<213> Homo sapiens

<400> 5687
Met Ser Asp Asp Phe Leu Trp Phe Glu Gly Ile Ala Phe Pro Thr Met
 1               5                  10                  15      
Gly Phe Arg Ser Glu Thr Leu Arg Lys Val Arg Asp Glu Phe Val Ile
            20                  25                  30          
Arg Asp Glu Asp Val Ile Ile Leu Thr Tyr Pro Lys Ser Gly Thr Asn
        35                  40                  45              
Trp Leu Ala Glu Ile Leu Cys Leu Met His Ser Lys Gly Asp Ala Lys
    50                  55                  60                  
Trp Ile Gln Ser Val Pro Ile Trp Glu Arg Ser Pro Trp Val Glu Ser
65                  70                  75                  80  
Glu Ile Gly Tyr Thr Ala Leu Ser Glu Thr Glu Ser Pro Arg Leu Phe
                85                  90                  95      
Ser Ser His Leu Pro Ile Gln Leu Phe Pro Lys Ser Phe Phe Ser Ser
            100                 105                 110         
Lys Ala Lys Val Ile Tyr Leu Met Arg Asn Pro Arg Asp Val Leu Val
        115                 120                 125             
Ser Gly Tyr Phe Phe Trp Lys Asn Met Lys Phe Ile Lys Lys Pro Lys
    130                 135                 140                 
Ser Trp Glu Glu Tyr Phe Glu Trp Phe Cys Gln Gly Thr Val Leu Tyr
145                 150                 155                 160 
Gly Ser Trp Phe Asp His Ile His Gly Trp Met Pro Met Arg Glu Glu
                165                 170                 175     
Lys Asn Phe Leu Leu Leu Ser Tyr Glu Glu Leu Lys Gln Asp Thr Gly
            180                 185                 190         
Arg Thr Ile Glu Lys Ile Cys Gln Phe Leu Gly Lys Thr Leu Glu Pro
        195                 200                 205             
Glu Glu Leu Asn Leu Ile Leu Lys Asn Ser Ser Phe Gln Ser Met Lys
    210                 215                 220                 
Glu Asn Lys Met Ser Asn Tyr Ser Leu Leu Ser Val Asp Tyr Val Val
225                 230                 235                 240 
Asp Lys Ala Gln Leu Leu Arg Lys Gly Val Ser Gly Asp Trp Lys Asn
                245                 250                 255     
His Phe Thr Val Ala Gln Ala Glu Asp Phe Asp Lys Leu Phe Gln Glu
            260                 265                 270         
Lys Met Ala Asp Leu Pro Arg Glu Leu Phe Pro Trp Glu
        275                 280                 285 


<210> 5688
<211> 3027
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 2862
<223> Xaa = Any Amino Acid

<400> 5688
Met Asn Leu His Gln Val Leu Thr Gly Ala Val Asn Pro Gly Asp His
 1               5                  10                  15      
Cys Phe Ser Val Gly Ser Ile Gly Asp Gln Arg Phe Thr Ala Tyr Ala
            20                  25                  30          
Ser Gly Cys Asp Ile Val Ile Leu Gly Ser Asp Phe Glu Arg Leu Gln
        35                  40                  45              
Ile Ile Pro Gly Ala Lys His Gly Asn Ile Gln Val Gly Cys Val Asp
    50                  55                  60                  
Cys Ser Met Gln Gln Gly Lys Ile Ala Ala Ser Tyr Gly Asn Val Ile
65                  70                  75                  80  
Ser Ile Phe Glu Pro Val Asn Leu Pro Lys Gln Lys Lys Asn Leu Glu
                85                  90                  95      
Leu Tyr Ser Gln Trp Gln Lys Ser Gly Gln Phe Phe Leu Glu Ser Ile
            100                 105                 110         
Ala His Asn Ile Thr Trp Asp Pro Thr Gly Ser Arg Leu Leu Thr Gly
        115                 120                 125             
Ser Ser Tyr Leu Gln Leu Trp Ser Asn Thr Asn Leu Glu Lys Pro Thr
    130                 135                 140                 
Glu Asp Glu Asn Leu Asn Lys Thr Asp Leu Asn Phe Gly Asp Trp Lys
145                 150                 155                 160 
Cys Ile Trp His Cys Lys Thr Ala Ser Gln Val His Leu Met Lys Phe
                165                 170                 175     
Ser Pro Asp Gly Glu Phe Phe Ala Thr Ala Gly Lys Asp Asp Cys Leu
            180                 185                 190         
Leu Lys Val Trp Tyr Asn Val Glu Asn Trp Arg Thr Ala Val Thr Ser
        195                 200                 205             
Pro Asp Gly Ser Ser Glu Lys Gln Ser Gln Gly Glu Ile Asp Phe Ser
    210                 215                 220                 
Phe Val Tyr Leu Ala His Pro Arg Ala Val Asn Gly Phe Ser Trp Arg
225                 230                 235                 240 
Lys Thr Ser Lys Tyr Met Pro Arg Ala Ser Val Cys Asn Val Leu Leu
                245                 250                 255     
Thr Cys Cys Lys Asp Asn Val Cys Arg Leu Trp Val Glu Thr Phe Leu
            260                 265                 270         
Pro Asn Asp Cys Leu Leu Tyr Gly Gly Asp Cys Ser His Trp Thr Glu
        275                 280                 285             
Ser Ile Asn Leu Thr Asn Asn Phe Lys Arg Asn Ala Ser Ser Lys Glu
    290                 295                 300                 
Arg Val Gln Asn Ala Leu Glu Val Asn Leu Arg His Phe Arg Arg Gly
305                 310                 315                 320 
Arg Arg Arg Ser Leu Ala Leu Val Ala His Thr Gly Tyr Leu Pro His
                325                 330                 335     
Gln Gln Asp Pro His His Val His Arg Asn Thr Pro Leu His Ala Asn
            340                 345                 350         
Ala Leu Cys His Phe His Ile Ala Ala Ser Ile Asn Pro Ala Thr Asp
        355                 360                 365             
Ile Pro Leu Leu Pro Ser Ile Thr Ser Leu Ser Leu Asn Glu Asn Glu
    370                 375                 380                 
Glu Lys Thr Gly Pro Phe Val Val His Trp Leu Asn Asn Lys Glu Leu
385                 390                 395                 400 
His Phe Thr Leu Ser Met Glu Val Phe Leu Gln Gln Leu Arg Lys Ser
                405                 410                 415     
Phe Glu Gln Pro Ser Ser Glu Ala Ser Val Glu Asp Ser Asn Gln Ala
            420                 425                 430         
Asp Val Lys Ser Asp Glu Glu Thr Asp Asp Gly Val Asp Asp Leu Lys
        435                 440                 445             
Ile Asn Pro Glu Lys Lys Glu Leu Gly Cys Asp Lys Met Val Pro Asn
    450                 455                 460                 
Ser Ser Phe Thr Ser Leu Ser Ser Ala Ala Ile Asp His Gln Ile Glu
465                 470                 475                 480 
Val Leu Leu Ser Glu Trp Ser Lys Asn Ala Asp Met Leu Phe Ser Ile
                485                 490                 495     
His Pro Met Asp Gly Ser Leu Leu Val Trp His Val Asp Trp Leu Asp
            500                 505                 510         
Glu Tyr Gln Pro Gly Met Phe Arg Gln Val Gln Val Ser Phe Val Ser
        515                 520                 525             
Arg Ile Pro Val Ala Phe Pro Thr Gly Asp Ala Asn Ser Leu Cys Lys
    530                 535                 540                 
Ser Ile Met Met Tyr Ala Cys Thr Lys Asn Val Asp Leu Ala Ile Gln
545                 550                 555                 560 
Gln Gly Lys Gln Lys Pro Ser Gly Leu Thr Arg Ser Thr Ser Met Leu
                565                 570                 575     
Ile Ser Ser Gly His Asn Lys Ser Ser Asn Ser Leu Lys Leu Ser Ile
            580                 585                 590         
Phe Thr Pro Asn Val Met Met Ile Ser Lys His Ala Asp Gly Ser Leu
        595                 600                 605             
Asn Gln Trp Leu Val Ser Phe Ala Glu Glu Ser Ala Phe Ser Thr Val
    610                 615                 620                 
Leu Ser Ile Ser His Lys Ser Arg Tyr Cys Gly His Arg Phe His Leu
625                 630                 635                 640 
Asn Asp Leu Ala Cys His Ser Val Leu Pro Leu Leu Leu Thr Thr Ser
                645                 650                 655     
His His Asn Ala Leu Arg Thr Pro Asp Val Asp Asn Pro Glu Gln Pro
            660                 665                 670         
Phe Asp Ala Leu Asn Ile Glu Glu Cys Ser Leu Thr Gln Gln Asn Lys
        675                 680                 685             
Ser Thr Val Asp Val Ala Phe Gln Asp Pro Ser Ala Val Tyr Ser Glu
    690                 695                 700                 
Leu Ile Leu Trp Arg Val Asp Pro Val Gly Pro Leu Ser Phe Ser Gly
705                 710                 715                 720 
Gly Val Ser Glu Leu Ala Arg Ile Asn Ser Leu His Val Ser Ala Phe
                725                 730                 735     
Ser Asn Val Ala Trp Leu Pro Thr Leu Ile Pro Ser Tyr Cys Leu Gly
            740                 745                 750         
Ala Tyr Cys Asn Ser Pro Ser Ala Cys Phe Val Ala Ser Asp Gly Gln
        755                 760                 765             
Tyr Leu Arg Leu Tyr Glu Ala Val Ile Asp Ala Lys Lys Leu Leu Ser
    770                 775                 780                 
Glu Leu Ser Asn Pro Glu Ile Ser Lys Tyr Val Gly Glu Val Phe Asn
785                 790                 795                 800 
Ile Val Ser Gln Gln Ser Thr Ala Arg Pro Gly Cys Ile Ile Ala Leu
                805                 810                 815     
Asp Pro Ile Thr Lys Leu His Gly Arg Lys Thr Gln Leu Leu His Val
            820                 825                 830         
Phe Glu Glu Asp Phe Ile Leu Asn Asn Leu Glu Lys Lys Ser Leu Gly
        835                 840                 845             
Lys Asp Ser Ile Leu Ser Asn Ala Gly Ser Ser Pro Asn Gly Phe Ser
    850                 855                 860                 
Glu Lys Phe Tyr Leu Ile Val Ile Glu Cys Thr Gln Asp Asn Arg Ser
865                 870                 875                 880 
Leu Leu His Met Trp Asn Leu His Leu Lys Ser Ile Pro Val Ser Leu
                885                 890                 895     
Asp Glu Lys Val Asp Thr Lys Leu Ser Glu Ala Val Trp Gln Pro Glu
            900                 905                 910         
Glu His Tyr Ser Ser Ser Pro Glu Lys Ile Leu Ser Pro Phe Ser Gln
        915                 920                 925             
Lys Tyr Gln Ala Cys Arg Ala Asn Leu Gln Ser Thr Ser Arg Leu Thr
    930                 935                 940                 
Leu Phe Ser Glu Met Val Tyr Ser Gln Glu Leu His Leu Pro Glu Gly
945                 950                 955                 960 
Val Glu Ile Ile Ser Ile Lys Pro Ser Ala Gly His Leu Ser Ser Ser
                965                 970                 975     
Ser Ile Tyr Pro Ala Cys Ser Ala Pro Tyr Leu Leu Ala Thr Ser Cys
            980                 985                 990         
Ser Asp Glu Lys Val Arg Phe Trp Arg Cys Arg Val Thr Asp Gly Glu
        995                 1000                1005            
Ser Ala Thr Ser Lys Asn Gly Lys Ile Asp Leu Ala Tyr Ile Trp Glu
    1010                1015                1020                
Glu Trp Pro Leu Leu Ile Glu Asp Gly Leu Gln Ser Asn Ser Ser Ile
1025                1030                1035                1040
Thr Val Pro Gly Arg Pro Val Glu Val Ser Cys Ala His Thr Asn Arg
                1045                1050                1055    
Leu Ala Val Ala Tyr Lys Gln Pro Ala Ser Asn Ser Arg Ser Ser Gln
            1060                1065                1070        
Asp Phe Val Met His Val Ser Ile Phe Glu Cys Glu Ser Thr Gly Gly
        1075                1080                1085            
Ser Cys Trp Val Leu Glu Gln Thr Ile His Leu Asp Glu Leu Ser Thr
    1090                1095                1100                
Val Leu Asp Ser Gly Ile Ser Val Asp Ser Asn Leu Val Ala Tyr Asn
1105                1110                1115                1120
Lys Gln Asp Met Tyr Leu Ser Ser Lys Glu Asn Ile Thr Ser Asn Thr
                1125                1130                1135    
Lys His Leu Val His Leu Asp Trp Met Ser Arg Glu Asp Gly Ser His
            1140                1145                1150        
Ile Leu Thr Val Gly Ile Gly Ser Lys Leu Phe Met Tyr Gly Pro Leu
        1155                1160                1165            
Ala Gly Lys Val Gln Asp Gln Thr Gly Lys Glu Thr Leu Ala Phe Pro
    1170                1175                1180                
Leu Trp Glu Ser Thr Lys Val Val Pro Leu Ser Lys Phe Val Leu Leu
1185                1190                1195                1200
Arg Ser Val Asp Leu Val Ser Ser Val Asp Gly Ser Pro Pro Phe Pro
                1205                1210                1215    
Val Ser Leu Ser Trp Val Arg Asp Gly Ile Leu Val Val Gly Met Asp
            1220                1225                1230        
Cys Glu Met His Val Tyr Cys Gln Trp Gln Pro Ser Ser Lys Gln Glu
        1235                1240                1245            
Pro Val Ile Thr Asp Ser Tyr Ser Gly Ser Thr Pro Ser Ile Thr Ser
    1250                1255                1260                
Leu Ile Lys Gln Ser Asn Ser Ser Ser Gly Leu His Pro Pro Lys Lys
1265                1270                1275                1280
Thr Leu Thr Arg Ser Met Thr Ser Leu Ala Gln Lys Ile Cys Gly Lys
                1285                1290                1295    
Lys Thr Ala Phe Asp Pro Ser Val Asp Met Glu Asp Ser Gly Leu Phe
            1300                1305                1310        
Glu Ala Ala His Val Leu Ser Pro Thr Leu Pro Gln Tyr His Pro Leu
        1315                1320                1325            
Gln Leu Leu Glu Leu Met Asp Leu Gly Lys Val Arg Arg Ala Lys Ala
    1330                1335                1340                
Ile Leu Ser His Leu Val Lys Cys Ile Ala Gly Glu Val Val Ala Leu
1345                1350                1355                1360
Asn Glu Ala Glu Ser Asn His Glu Arg Arg Leu Arg Ser Leu Thr Ile
                1365                1370                1375    
Ser Ala Ser Gly Ser Thr Thr Arg Asp Pro Gln Ala Phe Asn Lys Ala
            1380                1385                1390        
Glu Asn Thr Asp Tyr Thr Glu Ile Asp Ser Val Pro Pro Leu Pro Leu
        1395                1400                1405            
Tyr Ala Leu Leu Ala Ala Asp Asp Asp Ser Cys Tyr Ser Ser Leu Glu
    1410                1415                1420                
Lys Ser Ser Asn Glu Ser Thr Leu Ser Lys Ser Asn Gln Leu Ser Lys
1425                1430                1435                1440
Glu Ser Tyr Asp Glu Leu Phe Gln Thr Gln Leu Leu Met Thr Asp Thr
                1445                1450                1455    
His Met Leu Glu Thr Asp Glu Glu Asn Thr Lys Pro Arg Val Ile Asp
            1460                1465                1470        
Leu Ser Gln Tyr Ser Pro Thr Tyr Phe Gly Pro Glu His Ala Gln Val
        1475                1480                1485            
Leu Ser Gly His Leu Leu His Ser Ser Leu Pro Gly Leu Ser Arg Met
    1490                1495                1500                
Glu Gln Met Ser Leu Met Ala Leu Ala Asp Thr Ile Ala Thr Thr Ser
1505                1510                1515                1520
Thr Asp Ile Gly Glu Ser Arg Asp Arg Ser Gln Gly Gly Glu Thr Leu
                1525                1530                1535    
Asp Glu Cys Gly Leu Lys Phe Leu Leu Ala Val Arg Leu His Thr Phe
            1540                1545                1550        
Leu Thr Thr Ser Leu Pro Ala Tyr Arg Ala Gln Leu Leu His Gln Gly
        1555                1560                1565            
Leu Ser Thr Ser His Phe Ala Trp Ala Phe His Ser Val Ala Glu Glu
    1570                1575                1580                
Glu Leu Leu Asn Met Leu Pro Ala Met Gln Lys Asp Asp Pro Thr Trp
1585                1590                1595                1600
Ser Glu Leu Arg Ala Met Gly Val Gly Trp Trp Val Arg Asn Thr Arg
                1605                1610                1615    
Ile Leu Arg Lys Cys Ile Glu Lys Val Ala Lys Ala Ala Phe Tyr Arg
            1620                1625                1630        
Lys Asn Asp Pro Leu Asp Ala Ala Ile Phe Tyr Leu Ala Met Lys Lys
        1635                1640                1645            
Lys Ala Val Ile Trp Gly Leu Tyr Arg Ala Glu Lys Asn Thr Arg Met
    1650                1655                1660                
Thr Gln Phe Phe Gly His Asn Phe Glu Asp Glu Arg Trp Arg Lys Ala
1665                1670                1675                1680
Ala Leu Lys Asn Ala Phe Ser Leu Leu Gly Lys Gln Arg Phe Glu His
                1685                1690                1695    
Ser Ala Ala Phe Phe Leu Leu Ala Gly Cys Leu Arg Asp Ala Ile Glu
            1700                1705                1710        
Val Cys Leu Glu Lys Leu Asn Asp Ile Gln Leu Ala Leu Val Ile Ala
        1715                1720                1725            
Arg Leu Tyr Glu Ser Glu Phe Asp Thr Ser Ala Ala Tyr Lys Ser Ile
    1730                1735                1740                
Leu Arg Lys Lys Val Leu Gly Ile Asp Ser Pro Val Ser Glu Leu Cys
1745                1750                1755                1760
Ser Leu Asn Ile Asn Met His His Asp Pro Phe Leu Arg Ser Met Ala
                1765                1770                1775    
Tyr Trp Ile Leu Glu Asp Tyr Ser Gly Ala Leu Glu Thr Leu Ile Lys
            1780                1785                1790        
Gln Pro Ile Arg Glu Asn Asp Asp Gln Val Leu Ser Ala Ser Asn Pro
        1795                1800                1805            
Thr Val Phe Asn Phe Tyr Asn Tyr Leu Arg Thr His Pro Leu Leu Leu
    1810                1815                1820                
Arg Arg His Phe Gly Ser Ser Asp Thr Phe Ser Thr His Met Ser Leu
1825                1830                1835                1840
Thr Gly Lys Ser Gly Leu Ala Gly Thr Ile Asn Leu Ser Glu Arg Arg
                1845                1850                1855    
Leu Phe Phe Thr Thr Ala Ser Ala His Leu Lys Ala Gly Cys Pro Met
            1860                1865                1870        
Leu Ala Leu Glu Val Leu Ser Lys Met Pro Lys Val Ile Lys Lys Thr
        1875                1880                1885            
Arg Pro Phe Tyr Arg Ala Ser Ser Phe Leu Asp Thr Ser Lys Asp Cys
    1890                1895                1900                
Ser Pro Ser Ser Pro Leu Lys Leu Asp Ala Arg Glu Asp Lys Ser Ser
1905                1910                1915                1920
Ala Val Asp Trp Ser Gln Ser Leu Ile Asn Gly Phe Gly Ser Ser Ser
                1925                1930                1935    
Glu Gly Ser Ser Glu Lys Gln Ser Asn Ser Thr Leu Ser Phe Asp Trp
            1940                1945                1950        
Ser Gln Pro Ser Val Val Phe Gln Asp Asp Ser Leu Glu Leu Lys Trp
        1955                1960                1965            
Asp Ser Asp Asn Asp Glu Glu Asn Glu Asp Val Pro Ile Ser Met Lys
    1970                1975                1980                
Glu Leu Lys Pro Leu Gln Arg Lys Thr Asp Lys Lys Leu Asp Asp Ile
1985                1990                1995                2000
Ser Ser Asn Tyr Thr Glu Ser Phe Ser Thr Leu Asp Glu Asn Asp Leu
                2005                2010                2015    
Leu Asn Pro Ser Glu Asp Ile Ile Ala Val Gln Leu Lys Phe Arg Ala
            2020                2025                2030        
Cys Leu Lys Ile Leu Thr Val Glu Leu Arg Thr Leu Ser Thr Gly Tyr
        2035                2040                2045            
Glu Ile Asp Gly Gly Lys Leu Arg Tyr Gln Leu Tyr His Trp Leu Glu
    2050                2055                2060                
Lys Glu Val Ile Ala Leu Gln Arg Thr Cys Asp Phe Cys Ser Asp Ala
2065                2070                2075                2080
Glu Glu Leu Gln Ser Ala Phe Gly Arg Asn Glu Asp Glu Phe Gly Leu
                2085                2090                2095    
Asn Glu Asp Ala Glu Asp Leu Pro His Gln Thr Lys Val Lys Gln Leu
            2100                2105                2110        
Arg Glu Asn Phe Gln Glu Lys Arg Gln Trp Leu Leu Lys Tyr Gln Ser
        2115                2120                2125            
Leu Leu Arg Met Phe Leu Ser Tyr Cys Ile Leu His Gly Ser His Gly
    2130                2135                2140                
Gly Gly Leu Ala Ser Val Arg Met Glu Leu Ile Leu Leu Leu Gln Glu
2145                2150                2155                2160
Ser Gln Gln Glu Thr Ser Glu Pro Leu Phe Ser Ser Leu Leu Ser Glu
                2165                2170                2175    
Gln Thr Ser Val Pro Leu Leu Phe Ala Cys Thr Ala Asn Ala Lys Thr
            2180                2185                2190        
Val Val Ala Asn Pro Leu Leu His Leu Ser Asn Leu Thr His Asp Ile
        2195                2200                2205            
Leu His Ala Ile Ile Asn Phe Asp Ser Pro Pro His Pro Asp Ile Gln
    2210                2215                2220                
Ser Asn Lys Val Tyr Val Met His Thr Leu Ala Ala Ser Leu Ser Ala
2225                2230                2235                2240
Cys Ile Tyr Gln Cys Leu Cys Gly Ser His Asn Tyr Ser Ser Phe Gln
                2245                2250                2255    
Thr Asn Gln Phe Thr Gly Met Val Tyr Gln Thr Val Leu Leu Pro His
            2260                2265                2270        
Arg Pro Ser Leu Lys Thr Gly Ser Leu Asp Glu Ala Leu Thr Pro Asn
        2275                2280                2285            
Thr Ser Pro Ala Gln Trp Pro Gly Ile Thr Cys Leu Ile Arg Leu Leu
    2290                2295                2300                
Asn Ser Ser Gly Glu Glu Ala Gln Ser Gly Leu Thr Val Leu Leu Cys
2305                2310                2315                2320
Glu Ile Leu Thr Ala Val Tyr Leu Ser Leu Phe Ile His Gly Leu Ala
                2325                2330                2335    
Thr His Ser Ser Asn Glu Leu Phe Arg Ile Val Ala His Pro Leu Asn
            2340                2345                2350        
Glu Lys Met Trp Ser Ala Val Phe Gly Gly Gly Ala His Val Pro Ser
        2355                2360                2365            
Lys Glu Gln Thr His Ser Lys Thr Leu Pro Val Ser Ser Leu Val Glu
    2370                2375                2380                
Glu Gly Glu Lys Gln Asn Lys Arg Phe Arg Pro Ser Lys Met Ser Cys
2385                2390                2395                2400
Arg Glu Ser Ala Pro Leu Thr Pro Ser Ser Ala Pro Val Ser Gln Glu
                2405                2410                2415    
Ser Leu Ala Val Lys Glu Lys Phe Ile Pro Pro Glu Leu Ser Ile Trp
            2420                2425                2430        
Asp Tyr Phe Ile Ala Lys Pro Phe Leu Pro Ser Ser Gln Ser Arg Ala
        2435                2440                2445            
Glu Tyr Asp Ser Glx Glu Ser Leu Gly Ser Asp Asp Asp Asp Asn Asp
    2450                2455                2460                
Asp Asp Asp Asp Val Leu Ala Ser Asp Phe His Leu Gln Glu His Ser
2465                2470                2475                2480
Asn Ser Asn Ser Tyr Ser Trp Ser Leu Met Arg Leu Ala Met Val Gln
                2485                2490                2495    
Leu Val Leu Asn Asn Leu Lys Thr Phe Tyr Pro Phe Ala Gly His Asp
            2500                2505                2510        
Leu Ala Glu Leu Pro Val Ser Ser Pro Leu Cys His Ala Val Leu Lys
        2515                2520                2525            
Thr Leu Gln Cys Trp Glu Gln Val Leu Leu Arg Arg Leu Glu Ile His
    2530                2535                2540                
Gly Gly Pro Pro Gln Asn Tyr Ile Ala Ser His Thr Ala Glu Glu Ser
2545                2550                2555                2560
Leu Ser Ala Gly Pro Ala Ile Leu Arg His Lys Ala Leu Leu Glu Pro
                2565                2570                2575    
Thr Asn Thr Pro Phe Lys Ser Lys His His Leu Ala Leu Ser Val Lys
            2580                2585                2590        
Arg Leu Trp Gln Tyr Leu Val Lys Gln Glu Glu Ile Gln Glu Thr Phe
        2595                2600                2605            
Ile Lys Asn Ile Phe Thr Lys Lys Arg Cys Leu Asn Glu Ile Glu Ala
    2610                2615                2620                
Asp Leu Gly Tyr Pro Gly Gly Lys Ala Arg Ile Ile His Lys Glu Ser
2625                2630                2635                2640
Asp Ile Ile Thr Ala Phe Ala Val Asn Lys Ala Asn Arg Asn Cys Ile
                2645                2650                2655    
Ala Ile Ala Ser Ser His Asp Val Gln Glu Leu Asp Val Ser Gly Ile
            2660                2665                2670        
Leu Ala Thr Gln Val Tyr Thr Trp Val Asp Asp Asp Ile Glu Val Glu
        2675                2680                2685            
Thr Lys Gly Ser Glu Asp Phe Leu Val Ile His Ala Arg Asp Asp Leu
    2690                2695                2700                
Thr Ala Val Gln Gly Thr Thr Pro Tyr Thr His Ser Asn Pro Gly Thr
2705                2710                2715                2720
Pro Ile Asn Met Pro Trp Leu Gly Ser Thr Gln Thr Gly Arg Gly Ala
                2725                2730                2735    
Ser Val Met Ile Lys Lys Ala Ile Asn Asn Val Arg Arg Met Thr Ser
            2740                2745                2750        
His Pro Thr Leu Pro Tyr Tyr Leu Thr Gly Ala Gln Asp Gly Ser Val
        2755                2760                2765            
Arg Met Phe Glu Trp Gly His Ser Gln Gln Ile Thr Cys Phe Arg Ser
    2770                2775                2780                
Gly Gly Asn Ser Arg Val Thr Arg Met Arg Phe Asn Tyr Gln Gly Asn
2785                2790                2795                2800
Lys Phe Gly Ile Val Asp Ala Asp Gly Tyr Leu Ser Leu Tyr Gln Thr
                2805                2810                2815    
Asn Trp Lys Cys Cys Pro Val Thr Gly Ser Met Pro Lys Pro Tyr Leu
            2820                2825                2830        
Thr Trp Gln Cys His Asn Lys Thr Ala Asn Asp Phe Val Phe Val Ser
        2835                2840                2845            
Ser Ser Ser Leu Ile Ala Thr Ala Gly Leu Ser Thr Asp Xaa Arg Asn
    2850                2855                2860                
Val Cys Leu Trp Asp Thr Leu Val Ala Pro Ala Asp Ser Leu Val His
2865                2870                2875                2880
Ala Phe Thr Cys His Asp Ser Gly Ala Thr Val Leu Ala Tyr Ala Pro
                2885                2890                2895    
Lys His Gln Leu Leu Ile Ser Gly Gly Arg Lys Gly Phe Thr Tyr Val
            2900                2905                2910        
Phe Asp Leu Cys Gln Arg Gln Gln Arg Gln Leu Phe Gln Ser His Asp
        2915                2920                2925            
Ser Pro Val Lys Ala Val Ala Val Asp Pro Thr Glu Glu Tyr Phe Val
    2930                2935                2940                
Thr Gly Ser Ala Glu Gly Asn Ile Lys Ile Trp Ser Leu Ser Thr Phe
2945                2950                2955                2960
Gly Leu Leu His Thr Phe Val Ser Glu His Ala Arg Gln Ser Ile Phe
                2965                2970                2975    
Arg Asn Ile Gly Thr Gly Val Met Gln Ile Glu Thr Gly Pro Ala Asn
            2980                2985                2990        
His Ile Phe Ser Cys Gly Ala Asp Gly Thr Met Lys Met Arg Ile Leu
        2995                3000                3005            
Pro Asp Gln Phe Ser Pro Leu Asn Glu Val Leu Lys Asn Asp Val Lys
    3010                3015                3020                
Phe Met Leu
3025        


<210> 5689
<211> 164
<212> PRT
<213> Homo sapiens

<400> 5689
Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu
 1               5                  10                  15      
Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala
            20                  25                  30          
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys
        35                  40                  45              
Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly
    50                  55                  60                  
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu
65                  70                  75                  80  
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile
                85                  90                  95      
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe
            100                 105                 110         
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe
        115                 120                 125             
Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe
    130                 135                 140                 
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys
145                 150                 155                 160 
Gly Gln Leu Glu
                


<210> 5690
<211> 167
<212> PRT
<213> Homo sapiens

<400> 5690
Leu Ala Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly
 1               5                  10                  15      
Glu Pro Leu Gly Arg Val Ser Phe Glu Leu Leu Ala Asp Lys Val Pro
            20                  25                  30          
Lys Thr Ala Glu Asn Phe His Ala Leu Ser Thr Gly Glu Lys Gly Phe
        35                  40                  45              
Gly Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys
    50                  55                  60                  
Gln Gly Gly Asp Phe Thr Arg His Asn Gly Thr Ser Gly Lys Ser Ile
65                  70                  75                  80  
Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly
                85                  90                  95      
Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser
            100                 105                 110         
Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Met His
        115                 120                 125             
Val Ile Cys Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Val Met
    130                 135                 140                 
Glu Cys Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile
145                 150                 155                 160 
Ala Asp Cys Gly Gln Leu Glu
                165         


<210> 5691
<211> 179
<212> PRT
<213> Homo sapiens

<400> 5691
Met Ser Gly Val Trp Glu Gly Arg Ser Pro Val Val Ser Ala Ile Val
 1               5                  10                  15      
Asn Pro Thr Val Phe Phe Asn Ile Ala Ile Asn Gly Glu Pro Leu Gly
            20                  25                  30          
Cys Ile Ser Phe Glu Leu Phe Ala Asp Lys Phe Pro Lys Thr Ala Glu
        35                  40                  45              
Asn Leu Arg Val Leu Gly Met Gly Glu Lys Gly Phe Gly Cys Lys Gly
    50                  55                  60                  
Ser Arg Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp
65                  70                  75                  80  
Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys
                85                  90                  95      
Phe Asp Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu
            100                 105                 110         
Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile
        115                 120                 125             
Cys Thr Ala Lys Ser Glu Trp Leu Asp Gly Lys His Val Val Phe Gly
    130                 135                 140                 
Lys Met Lys Glu Gly Ile Asn Ile Val Glu Ala Thr Gly Arg Phe Gly
145                 150                 155                 160 
Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly
                165                 170                 175     
Gln Leu Glu
            


<210> 5692
<211> 446
<212> PRT
<213> Homo sapiens

<400> 5692
Met Glu Gly Gln Glu Asn Lys Val Ser Lys Thr Ala Glu Asn Phe Arg
 1               5                  10                  15      
Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Cys Lys Gly Ser Cys Phe
            20                  25                  30          
His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Cys
        35                  40                  45              
His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Trp Glu Lys Phe Asp Asp
    50                  55                  60                  
Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala
65                  70                  75                  80  
Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala
                85                  90                  95      
Lys Thr Lys Trp Leu Asp Gly Lys His Val Ala Phe Gly Lys Val Ser
            100                 105                 110         
Ala Phe Ile Ser Ser Ser Val Leu Leu Asp Pro Tyr Asp Val Arg Tyr
        115                 120                 125             
Gly Leu Gly Asp Val Leu Phe Pro Leu Ala Asp Gly Ser Leu Gln Thr
    130                 135                 140                 
Leu Arg Gly Pro Gln Ala Trp Asn Val Arg Asn Leu Leu Gly Leu Pro
145                 150                 155                 160 
Ile Leu Gly Pro Lys Trp Pro Lys Pro Val Gly Phe Ser Gln Ile Lys
                165                 170                 175     
Glu Lys Val Gly Thr Lys Gly Val Lys Ser Lys Glu Ser Cys Arg Lys
            180                 185                 190         
Glu Arg Lys Ser Leu Gly Ser Lys Met Thr Ser Gly Glu Val Lys Thr
        195                 200                 205             
Ser Leu Lys Asn Ala Tyr Ser Ser Ala Lys Arg Leu Ser Pro Lys Met
    210                 215                 220                 
Glu Glu Glu Gly Glu Glu Glu Asp Tyr Cys Thr Pro Gly Ala Phe Glu
225                 230                 235                 240 
Leu Glu Arg Leu Phe Trp Lys Gly Ser Pro Gln Tyr Thr His Val Asn
                245                 250                 255     
Glu Val Trp Pro Lys Leu Tyr Ile Gly Asp Glu Ala Thr Ala Leu Asp
            260                 265                 270         
Arg Tyr Arg Leu Gln Lys Ala Gly Phe Thr His Val Leu Asn Ala Ala
        275                 280                 285             
His Gly Arg Trp Asn Val Asp Thr Gly Pro Asp Tyr Tyr Arg Asp Met
    290                 295                 300                 
Asp Ile Gln Tyr His Gly Val Glu Ala Asp Asp Leu Pro Thr Phe Asp
305                 310                 315                 320 
Leu Ser Val Phe Phe Tyr Pro Ala Ala Ala Phe Ile Asp Arg Ala Leu
                325                 330                 335     
Ser Asp Asp His Ser Arg Lys Arg Asp Val Arg Val Arg Asn Leu Cys
            340                 345                 350         
Arg Lys Ala Gly Pro Leu Gly Leu Leu Val Ala Glu Gly Lys Gly Lys
        355                 360                 365             
Ile Leu Val His Cys Val Met Gly Arg Ser Arg Ser Ala Thr Leu Val
    370                 375                 380                 
Leu Ala Tyr Leu Met Ile His Lys Asp Met Thr Leu Val Asp Ala Ile
385                 390                 395                 400 
Gln Gln Val Ala Lys Asn Arg Cys Val Leu Pro Asn Arg Gly Phe Leu
                405                 410                 415     
Lys Gln Leu Arg Glu Leu Asp Lys Gln Leu Val Gln Gln Arg Arg Arg
            420                 425                 430         
Ser Gln Arg Gln Asp Gly Glu Glu Glu Asp Gly Arg Glu Leu
        435                 440                 445     


<210> 5693
<211> 214
<212> PRT
<213> Homo sapiens

<400> 5693
Met Thr Phe Leu Leu Ile His Phe Ser Gly Gln Gln Gln Lys His Arg
 1               5                  10                  15      
Tyr Ala Ser Gly Gln Tyr Leu Arg Leu Asn Glu Phe Ser His Phe Ala
            20                  25                  30          
Pro Pro Gln Glu Ala Lys Asn Ala Ala Val Gly Ser Ser Val Leu Pro
        35                  40                  45              
Ala Met Val Asn Pro Thr Val Phe Phe His Ile Ser Val Asp Gly Glu
    50                  55                  60                  
Ser Leu Gly Arg Ile Ser Phe Glu Leu Phe Ala Asp Lys Phe Pro Lys
65                  70                  75                  80  
Thr Ala Glu Asn Phe Cys Ala Leu Asn Thr Gly Glu Lys Gly Phe Gly
                85                  90                  95      
Tyr Lys Gly Cys Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys His
            100                 105                 110         
Gly Gly Asp Phe Thr His His Asn Gly Thr Gly Gly Lys Ser Ile Tyr
        115                 120                 125             
Gly Glu Lys Val Asp Asp Asp Asn Phe Ile Leu Lys His Thr Gly Pro
    130                 135                 140                 
Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln
145                 150                 155                 160 
Phe Phe Ile Cys Thr Ala Lys Ser Glu Trp Leu Asp Ser Lys His Val
                165                 170                 175     
Val Ile Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu
            180                 185                 190         
His Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Val Thr Ile Pro
        195                 200                 205             
Asp Phe Gly Gln Leu Glu
    210                 


<210> 5694
<211> 172
<212> PRT
<213> Homo sapiens

<400> 5694
Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro
 1               5                  10                  15      
Leu Gly Arg Val Ser Phe Glu Val Gly Arg Ala Ala Ala Cys Gly Asn
            20                  25                  30          
Gly Ala Gln Lys Val Gly Arg Gly Arg Glu Asn Phe Arg Ala Leu Ser
        35                  40                  45              
Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His Arg Ile
    50                  55                  60                  
Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly
65                  70                  75                  80  
Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe
                85                  90                  95      
Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly
            100                 105                 110         
Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu
        115                 120                 125             
Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met
    130                 135                 140                 
Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr
145                 150                 155                 160 
Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu
                165                 170         


<210> 5695
<211> 141
<212> PRT
<213> Homo sapiens

<400> 5695
Leu Phe Ala Asp Lys Phe Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu
 1               5                  10                  15      
Ser Thr Gly Glu Lys Gly Phe Ser Tyr Lys Gly Ser Cys Phe His Arg
            20                  25                  30          
Ile Ile Pro Gly Phe Met Tyr Gln Gly Arg Asp Phe Thr Arg His Asn
        35                  40                  45              
Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn
    50                  55                  60                  
Phe Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala
65                  70                  75                  80  
Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr
                85                  90                  95      
Glu Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly
            100                 105                 110         
Met Asn Ile Met Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys
        115                 120                 125             
Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu
    130                 135                 140     


<210> 5696
<211> 189
<212> PRT
<213> Homo sapiens

<400> 5696
Met Ser Gln Arg Ala Gly His Glu Glu Asn Pro Val Glu Asn Tyr Asp
 1               5                  10                  15      
Lys Lys Phe Thr Thr Glu Leu Lys Gln Leu Leu Gly Phe Ala Asp Ala
            20                  25                  30          
Ala Ala Glu Glu Asn Arg Val Leu Leu Ala Met Val Asn Pro Thr Val
        35                  40                  45              
Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu Gly Arg Val Ser Phe
    50                  55                  60                  
Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala Gly Phe His Arg Ile
65                  70                  75                  80  
Ile Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr Arg His Asn Gly
                85                  90                  95      
Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe
            100                 105                 110         
Ile Leu Lys His Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly
        115                 120                 125             
Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu
    130                 135                 140                 
Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met
145                 150                 155                 160 
Asn Ile Val Glu Ala Met Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr
                165                 170                 175     
Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu Glu
            180                 185                 


<210> 5697
<211> 167
<212> PRT
<213> Homo sapiens

<400> 5697
Leu Ala Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly
 1               5                  10                  15      
Glu Pro Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro
            20                  25                  30          
Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe
        35                  40                  45              
Gly Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys
    50                  55                  60                  
Gln Gly Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile
65                  70                  75                  80  
Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly
                85                  90                  95      
Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser
            100                 105                 110         
Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His
        115                 120                 125             
Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met
    130                 135                 140                 
Glu Arg Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile
145                 150                 155                 160 
Ala Asp Cys Gly Gln Leu Glu
                165         


<210> 5698
<211> 1419
<212> PRT
<213> Homo sapiens

<400> 5698
Met Asp Gly Gly Gly Val Cys Val Gly Arg Gly Asp Leu Leu Ser Ser
 1               5                  10                  15      
Pro Gln Ala Leu Gly Gln Leu Leu Arg Lys Glu Ser Arg Pro Arg Arg
            20                  25                  30          
Ala Met Lys Pro Arg Lys Ala Glu Pro His Ser Phe Arg Glu Lys Val
        35                  40                  45              
Phe Arg Lys Lys Pro Pro Val Cys Ala Val Cys Lys Val Thr Ile Asp
    50                  55                  60                  
Gly Thr Gly Val Ser Cys Arg Val Cys Lys Val Ala Thr His Arg Lys
65                  70                  75                  80  
Cys Glu Ala Lys Val Thr Ser Ala Cys Gln Ala Leu Pro Pro Val Glu
                85                  90                  95      
Leu Arg Arg Asn Thr Ala Pro Val Arg Arg Ile Glu His Leu Gly Ser
            100                 105                 110         
Thr Lys Ser Leu Asn His Ser Lys Gln Arg Ser Thr Leu Pro Arg Ser
        115                 120                 125             
Phe Ser Leu Asp Pro Leu Met Glu Arg Arg Trp Asp Leu Asp Leu Thr
    130                 135                 140                 
Tyr Val Thr Glu Arg Ile Leu Ala Ala Ala Phe Pro Ala Arg Pro Asp
145                 150                 155                 160 
Glu Gln Arg His Arg Gly His Leu Arg Glu Leu Ala His Val Leu Gln
                165                 170                 175     
Ser Lys His Arg Asp Lys Tyr Leu Leu Phe Asn Leu Ser Glu Lys Arg
            180                 185                 190         
His Asp Leu Thr Arg Leu Asn Pro Lys Val Gln Asp Phe Gly Trp Pro
        195                 200                 205             
Glu Leu His Ala Pro Pro Leu Asp Lys Leu Cys Ser Ile Cys Lys Ala
    210                 215                 220                 
Met Glu Thr Trp Leu Ser Ala Asp Pro Gln His Val Val Val Leu Tyr
225                 230                 235                 240 
Cys Lys Gly Asn Lys Gly Lys Leu Gly Val Ile Val Ser Ala Tyr Met
                245                 250                 255     
His Tyr Ser Lys Ile Ser Ala Gly Ala Asp Gln Ala Leu Ala Thr Leu
            260                 265                 270         
Thr Met Arg Lys Phe Cys Glu Asp Lys Val Ala Thr Glu Leu Gln Pro
        275                 280                 285             
Ser Gln Arg Arg Tyr Ile Ser Tyr Phe Ser Gly Leu Leu Ser Gly Ser
    290                 295                 300                 
Ile Arg Met Asn Ser Ser Pro Leu Phe Leu His Tyr Val Leu Ile Pro
305                 310                 315                 320 
Met Leu Pro Ala Phe Glu Pro Gly Thr Gly Phe Gln Pro Phe Leu Lys
                325                 330                 335     
Ile Tyr Gln Ser Met Gln Leu Val Tyr Thr Ser Gly Val Tyr His Ile
            340                 345                 350         
Ala Gly Pro Gly Pro Gln Gln Leu Cys Ile Ser Leu Glu Pro Ala Leu
        355                 360                 365             
Leu Leu Lys Gly Asp Val Met Val Thr Cys Tyr His Lys Gly Gly Arg
    370                 375                 380                 
Gly Thr Asp Arg Thr Leu Val Phe Arg Val Gln Phe His Thr Cys Thr
385                 390                 395                 400 
Ile His Gly Pro Gln Leu Thr Phe Pro Lys Asp Gln Leu Asp Glu Ala
                405                 410                 415     
Trp Thr Asp Glu Arg Phe Pro Phe Gln Ala Ser Val Glu Phe Val Phe
            420                 425                 430         
Ser Ser Ser Pro Glu Lys Ile Lys Gly Ser Thr Pro Arg Asn Asp Pro
        435                 440                 445             
Ser Val Ser Val Asp Tyr Asn Thr Thr Glu Pro Ala Val Arg Trp Asp
    450                 455                 460                 
Ser Tyr Glu Asn Phe Asn Gln His His Glu Asp Ser Val Asp Gly Ser
465                 470                 475                 480 
Leu Thr His Thr Arg Gly Pro Leu Asp Gly Ser Pro Tyr Ala Gln Val
                485                 490                 495     
Gln Arg Pro Pro Arg Gln Thr Pro Pro Ala Pro Ser Pro Glu Pro Pro
            500                 505                 510         
Pro Pro Pro Met Leu Ser Val Ser Ser Asp Ser Gly His Ser Ser Thr
        515                 520                 525             
Leu Thr Thr Glu Pro Ala Ala Glu Ser Pro Gly Arg Pro Pro Pro Thr
    530                 535                 540                 
Ala Ala Glu Arg Gln Glu Leu Asp Arg Leu Leu Gly Gly Cys Gly Val
545                 550                 555                 560 
Ala Ser Gly Gly Arg Gly Ala Gly Arg Glu Thr Ala Ile Leu Asp Asp
                565                 570                 575     
Glu Glu Gln Pro Thr Val Gly Gly Gly Pro His Leu Gly Val Tyr Pro
            580                 585                 590         
Gly His Arg Pro Gly Leu Ser Arg His Cys Ser Cys Arg Gln Gly Tyr
        595                 600                 605             
Arg Glu Pro Cys Gly Val Pro Asn Gly Gly Tyr Tyr Arg Pro Glu Gly
    610                 615                 620                 
Thr Leu Glu Arg Arg Arg Leu Ala Tyr Gly Gly Tyr Glu Gly Ser Pro
625                 630                 635                 640 
Gln Gly Tyr Ala Glu Ala Ser Met Glu Lys Arg Arg Leu Cys Arg Ser
                645                 650                 655     
Leu Ser Glu Gly Leu Tyr Pro Tyr Pro Pro Glu Met Gly Lys Pro Ala
            660                 665                 670         
Thr Gly Asp Phe Gly Tyr Arg Ala Pro Gly Tyr Arg Glu Val Val Ile
        675                 680                 685             
Leu Glu Asp Pro Gly Leu Pro Ala Leu Tyr Pro Cys Pro Ala Cys Glu
    690                 695                 700                 
Glu Lys Leu Ala Leu Pro Thr Ala Ala Leu Tyr Gly Leu Arg Leu Glu
705                 710                 715                 720 
Arg Glu Ala Gly Glu Gly Trp Ala Ser Glu Ala Gly Lys Pro Leu Leu
                725                 730                 735     
His Pro Val Arg Pro Gly His Pro Leu Pro Leu Leu Leu Pro Ala Cys
            740                 745                 750         
Gly His His His Ala Pro Met Pro Asp Tyr Ser Cys Leu Lys Pro Pro
        755                 760                 765             
Lys Ala Gly Glu Glu Gly His Glu Gly Cys Ser Tyr Thr Met Cys Pro
    770                 775                 780                 
Glu Gly Arg Tyr Gly His Pro Gly Tyr Pro Ala Leu Val Thr Tyr Ser
785                 790                 795                 800 
Tyr Gly Gly Ala Val Pro Ser Tyr Cys Pro Ala Tyr Gly Arg Val Pro
                805                 810                 815     
His Ser Cys Gly Ser Pro Gly Glu Gly Arg Gly Tyr Pro Ser Pro Gly
            820                 825                 830         
Ala His Ser Pro Arg Ala Gly Ser Ile Ser Pro Gly Ser Pro Pro Tyr
        835                 840                 845             
Pro Gln Ser Arg Lys Leu Ser Tyr Glu Ile Pro Thr Glu Glu Gly Gly
    850                 855                 860                 
Asp Arg Tyr Pro Leu Pro Gly His Leu Ala Ser Ala Gly Pro Leu Ala
865                 870                 875                 880 
Ser Ala Glu Ser Leu Glu Pro Val Ser Trp Arg Glu Gly Pro Ser Gly
                885                 890                 895     
His Ser Thr Leu Pro Arg Ser Pro Arg Asp Ala Pro Cys Ser Ala Ser
            900                 905                 910         
Ser Glu Leu Ser Gly Pro Ser Thr Pro Leu His Thr Ser Ser Pro Val
        915                 920                 925             
Gln Gly Lys Glu Ser Thr Arg Arg Gln Asp Thr Arg Ser Pro Thr Ser
    930                 935                 940                 
Ala Pro Thr Gln Arg Leu Ser Pro Gly Glu Ala Leu Pro Pro Val Ser
945                 950                 955                 960 
Gln Ala Gly Thr Gly Lys Ala Pro Glu Leu Pro Ser Gly Ser Gly Pro
                965                 970                 975     
Glu Pro Leu Ala Pro Ser Pro Val Ser Pro Thr Phe Pro Pro Ser Ser
            980                 985                 990         
Pro Ser Asp Trp Pro Gln Glu Arg Ser Pro Gly Gly His Ser Asp Gly
        995                 1000                1005            
Ala Ser Pro Arg Ser Pro Val Pro Thr Thr Leu Pro Gly Leu Arg His
    1010                1015                1020                
Ala Pro Trp Gln Gly Pro Arg Gly Pro Pro Asp Ser Pro Asp Gly Ser
1025                1030                1035                1040
Pro Leu Thr Pro Val Pro Ser Gln Met Pro Trp Leu Val Ala Ser Pro
                1045                1050                1055    
Glu Pro Pro Gln Ser Ser Pro Thr Pro Ala Phe Pro Leu Ala Ala Ser
            1060                1065                1070        
Tyr Asp Thr Asn Gly Leu Ser Gln Pro Pro Leu Pro Glu Lys Arg His
        1075                1080                1085            
Leu Pro Gly Pro Gly Gln Gln Pro Gly Pro Trp Gly Pro Glu Gln Ala
    1090                1095                1100                
Ser Ser Pro Ala Arg Gly Ile Ser His His Val Thr Phe Ala Pro Leu
1105                1110                1115                1120
Leu Ser Asp Asn Val Pro Gln Thr Pro Glu Pro Pro Thr Gln Glu Ser
                1125                1130                1135    
Gln Ser Asn Val Lys Phe Val Gln Asp Thr Ser Lys Phe Trp Tyr Lys
            1140                1145                1150        
Pro His Leu Ser Arg Asp Gln Ala Ile Ala Leu Leu Lys Asp Lys Asp
        1155                1160                1165            
Pro Gly Ala Phe Leu Ile Arg Asp Ser His Ser Phe Gln Gly Ala Tyr
    1170                1175                1180                
Gly Leu Ala Leu Lys Val Ala Thr Pro Pro Pro Ser Ala Gln Pro Trp
1185                1190                1195                1200
Lys Gly Asp Pro Val Glu Gln Leu Val Arg His Phe Leu Ile Glu Thr
                1205                1210                1215    
Gly Pro Lys Gly Val Lys Ile Lys Gly Cys Pro Ser Glu Pro Tyr Phe
            1220                1225                1230        
Gly Ser Leu Ser Ala Leu Val Ser Gln His Ser Ile Ser Pro Ile Ser
        1235                1240                1245            
Leu Pro Cys Cys Leu Arg Ile Leu Ser Lys Asp Pro Leu Glu Glu Thr
    1250                1255                1260                
Pro Glu Ala Pro Val Pro Thr Asn Met Ser Thr Ala Ala Asp Leu Leu
1265                1270                1275                1280
Arg Gln Gly Ala Ala Cys Ser Val Leu Tyr Leu Thr Ser Val Glu Thr
                1285                1290                1295    
Glu Ser Leu Thr Gly Pro Gln Ala Val Ala Arg Ala Ser Ser Ala Ala
            1300                1305                1310        
Leu Ser Cys Ser Pro Arg Pro Thr Pro Ala Val Val His Phe Lys Val
        1315                1320                1325            
Ser Ala Gln Gly Ile Thr Leu Thr Asp Asn Gln Arg Lys Leu Phe Phe
    1330                1335                1340                
Arg Arg His Tyr Pro Val Asn Ser Ile Thr Phe Ser Ser Thr Asp Pro
1345                1350                1355                1360
Gln Asp Arg Arg Trp Thr Asn Pro Asp Gly Thr Thr Ser Lys Ile Phe
                1365                1370                1375    
Gly Phe Val Ala Lys Lys Pro Gly Ser Pro Trp Glu Asn Val Cys His
            1380                1385                1390        
Leu Phe Ala Glu Leu Asp Pro Asp Gln Pro Ala Gly Ala Ile Val Thr
        1395                1400                1405            
Phe Ile Thr Lys Val Leu Leu Gly Gln Arg Lys
    1410                1415                


<210> 5699
<211> 1285
<212> PRT
<213> Homo sapiens

<400> 5699
Met Glu Arg Arg Trp Asp Leu Asp Leu Thr Tyr Val Thr Glu Arg Ile
 1               5                  10                  15      
Leu Ala Ala Ala Phe Pro Ala Arg Pro Asp Glu Gln Arg His Arg Gly
            20                  25                  30          
His Leu Arg Glu Leu Ala His Val Leu Gln Ser Lys His Arg Asp Lys
        35                  40                  45              
Tyr Leu Leu Phe Asn Leu Ser Glu Lys Arg His Asp Leu Thr Arg Leu
    50                  55                  60                  
Asn Pro Lys Val Gln Asp Phe Gly Trp Pro Glu Leu His Ala Pro Pro
65                  70                  75                  80  
Leu Asp Lys Leu Cys Ser Ile Cys Lys Ala Met Glu Thr Trp Leu Ser
                85                  90                  95      
Ala Asp Pro Gln His Val Val Val Leu Tyr Cys Lys Gly Asn Lys Gly
            100                 105                 110         
Lys Leu Gly Val Ile Val Ser Ala Tyr Met His Tyr Ser Lys Ile Ser
        115                 120                 125             
Ala Gly Ala Asp Gln Ala Leu Ala Thr Leu Thr Met Arg Lys Phe Cys
    130                 135                 140                 
Glu Asp Lys Val Ala Thr Glu Leu Gln Pro Ser Gln Arg Arg Tyr Ile
145                 150                 155                 160 
Ser Tyr Phe Ser Gly Leu Leu Ser Gly Ser Ile Arg Met Asn Ser Ser
                165                 170                 175     
Pro Leu Phe Leu His Tyr Val Leu Ile Pro Met Leu Pro Ala Phe Glu
            180                 185                 190         
Pro Gly Thr Gly Phe Gln Pro Phe Leu Lys Ile Tyr Gln Ser Met Gln
        195                 200                 205             
Leu Val Tyr Thr Ser Gly Val Tyr His Ile Ala Gly Pro Gly Pro Gln
    210                 215                 220                 
Gln Leu Cys Ile Ser Leu Glu Pro Ala Leu Leu Leu Lys Gly Asp Val
225                 230                 235                 240 
Met Val Thr Cys Tyr His Lys Gly Gly Arg Gly Thr Asp Arg Thr Leu
                245                 250                 255     
Val Phe Arg Val Gln Phe His Thr Cys Thr Ile His Gly Pro Gln Leu
            260                 265                 270         
Thr Phe Pro Lys Asp Gln Leu Asp Glu Ala Trp Thr Asp Glu Arg Phe
        275                 280                 285             
Pro Phe Gln Ala Ser Val Glu Phe Val Phe Ser Ser Ser Pro Glu Lys
    290                 295                 300                 
Ile Lys Gly Ser Thr Pro Arg Asn Asp Pro Ser Val Ser Val Asp Tyr
305                 310                 315                 320 
Asn Thr Thr Glu Pro Ala Val Arg Trp Asp Ser Tyr Glu Asn Phe Asn
                325                 330                 335     
Gln His His Glu Asp Ser Val Asp Gly Ser Leu Thr His Thr Arg Gly
            340                 345                 350         
Pro Leu Asp Gly Ser Pro Tyr Ala Gln Val Gln Arg Pro Pro Arg Gln
        355                 360                 365             
Thr Pro Pro Ala Pro Ser Pro Glu Pro Pro Pro Pro Pro Met Leu Ser
    370                 375                 380                 
Val Ser Ser Asp Ser Gly His Ser Ser Thr Leu Thr Thr Glu Pro Ala
385                 390                 395                 400 
Ala Glu Ser Pro Gly Arg Pro Pro Pro Thr Ala Ala Glu Arg Gln Glu
                405                 410                 415     
Leu Asp Arg Leu Leu Gly Gly Cys Gly Val Ala Ser Gly Gly Arg Gly
            420                 425                 430         
Ala Gly Arg Glu Thr Ala Ile Leu Asp Asp Glu Glu Gln Pro Thr Val
        435                 440                 445             
Gly Gly Gly Pro His Leu Gly Val Tyr Pro Gly His Arg Pro Gly Leu
    450                 455                 460                 
Ser Arg His Cys Ser Cys Arg Gln Gly Tyr Arg Glu Pro Cys Gly Val
465                 470                 475                 480 
Pro Asn Gly Gly Tyr Tyr Arg Pro Glu Gly Thr Leu Glu Arg Arg Arg
                485                 490                 495     
Leu Ala Tyr Gly Gly Tyr Glu Gly Ser Pro Gln Gly Tyr Ala Glu Ala
            500                 505                 510         
Ser Met Glu Lys Arg Arg Leu Cys Arg Ser Leu Ser Glu Gly Leu Tyr
        515                 520                 525             
Pro Tyr Pro Pro Glu Met Gly Lys Pro Ala Thr Gly Asp Phe Gly Tyr
    530                 535                 540                 
Arg Ala Pro Gly Tyr Arg Glu Val Val Ile Leu Glu Asp Pro Gly Leu
545                 550                 555                 560 
Pro Ala Leu Tyr Pro Cys Pro Ala Cys Glu Glu Lys Leu Ala Leu Pro
                565                 570                 575     
Thr Ala Ala Leu Tyr Gly Leu Arg Leu Glu Arg Glu Ala Gly Glu Gly
            580                 585                 590         
Trp Ala Ser Glu Ala Gly Lys Pro Leu Leu His Pro Val Arg Pro Gly
        595                 600                 605             
His Pro Leu Pro Leu Leu Leu Pro Ala Cys Gly His His His Ala Pro
    610                 615                 620                 
Met Pro Asp Tyr Ser Cys Leu Lys Pro Pro Lys Ala Gly Glu Glu Gly
625                 630                 635                 640 
His Glu Gly Cys Ser Tyr Thr Met Cys Pro Glu Gly Arg Tyr Gly His
                645                 650                 655     
Pro Gly Tyr Pro Ala Leu Val Thr Tyr Ser Tyr Gly Gly Ala Val Pro
            660                 665                 670         
Ser Tyr Cys Pro Ala Tyr Gly Arg Val Pro His Ser Cys Gly Ser Pro
        675                 680                 685             
Gly Glu Gly Arg Gly Tyr Pro Ser Pro Gly Ala His Ser Pro Arg Ala
    690                 695                 700                 
Gly Ser Ile Ser Pro Gly Ser Pro Pro Tyr Pro Gln Ser Arg Lys Leu
705                 710                 715                 720 
Ser Tyr Glu Ile Pro Thr Glu Glu Gly Gly Asp Arg Tyr Pro Leu Pro
                725                 730                 735     
Gly His Leu Ala Ser Ala Gly Pro Leu Ala Ser Ala Glu Ser Leu Glu
            740                 745                 750         
Pro Val Ser Trp Arg Glu Gly Pro Ser Gly His Ser Thr Leu Pro Arg
        755                 760                 765             
Ser Pro Arg Asp Ala Pro Cys Ser Ala Ser Ser Glu Leu Ser Gly Pro
    770                 775                 780                 
Ser Thr Pro Leu His Thr Ser Ser Pro Val Gln Gly Lys Glu Ser Thr
785                 790                 795                 800 
Arg Arg Gln Asp Thr Arg Ser Pro Thr Ser Ala Pro Thr Gln Arg Leu
                805                 810                 815     
Ser Pro Gly Glu Ala Leu Pro Pro Val Ser Gln Ala Gly Thr Gly Lys
            820                 825                 830         
Ala Pro Glu Leu Pro Ser Gly Ser Gly Pro Glu Pro Leu Ala Pro Ser
        835                 840                 845             
Pro Val Ser Pro Thr Phe Pro Pro Ser Ser Pro Ser Asp Trp Pro Gln
    850                 855                 860                 
Glu Arg Ser Pro Gly Gly His Ser Asp Gly Ala Ser Pro Arg Ser Pro
865                 870                 875                 880 
Val Pro Thr Thr Leu Pro Gly Leu Arg His Ala Pro Trp Gln Gly Pro
                885                 890                 895     
Arg Gly Pro Pro Asp Ser Pro Asp Gly Ser Pro Leu Thr Pro Val Pro
            900                 905                 910         
Ser Gln Met Pro Trp Leu Val Ala Ser Pro Glu Pro Pro Gln Ser Ser
        915                 920                 925             
Pro Thr Pro Ala Phe Pro Leu Ala Ala Ser Tyr Asp Thr Asn Gly Leu
    930                 935                 940                 
Ser Gln Pro Pro Leu Pro Glu Lys Arg His Leu Pro Gly Pro Gly Gln
945                 950                 955                 960 
Gln Pro Gly Pro Trp Gly Pro Glu Gln Ala Ser Ser Pro Ala Arg Gly
                965                 970                 975     
Ile Ser His His Val Thr Phe Ala Pro Leu Leu Ser Asp Asn Val Pro
            980                 985                 990         
Gln Thr Pro Glu Pro Pro Thr Gln Glu Ser Gln Ser Asn Val Lys Phe
        995                 1000                1005            
Val Gln Asp Thr Ser Lys Phe Trp Tyr Lys Pro His Leu Ser Arg Asp
    1010                1015                1020                
Gln Ala Ile Ala Leu Leu Lys Asp Lys Asp Pro Gly Ala Phe Leu Ile
1025                1030                1035                1040
Arg Asp Ser His Ser Phe Gln Gly Ala Tyr Gly Leu Ala Leu Lys Val
                1045                1050                1055    
Ala Thr Pro Pro Pro Ser Ala Gln Pro Trp Lys Gly Asp Pro Val Glu
            1060                1065                1070        
Gln Leu Val Arg His Phe Leu Ile Glu Thr Gly Pro Lys Gly Val Lys
        1075                1080                1085            
Ile Lys Gly Cys Pro Ser Glu Pro Tyr Phe Gly Ser Leu Ser Ala Leu
    1090                1095                1100                
Val Ser Gln His Ser Ile Ser Pro Ile Ser Leu Pro Cys Cys Leu Arg
1105                1110                1115                1120
Ile Leu Ser Lys Asp Pro Leu Glu Glu Thr Pro Glu Ala Pro Val Pro
                1125                1130                1135    
Thr Asn Met Ser Thr Ala Ala Asp Leu Leu Arg Gln Gly Ala Ala Cys
            1140                1145                1150        
Ser Val Leu Tyr Leu Thr Ser Val Glu Thr Glu Ser Leu Thr Gly Pro
        1155                1160                1165            
Gln Ala Val Ala Arg Ala Ser Ser Ala Ala Leu Ser Cys Ser Pro Arg
    1170                1175                1180                
Pro Thr Pro Ala Val Val His Phe Lys Val Ser Ala Gln Gly Ile Thr
1185                1190                1195                1200
Leu Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Val
                1205                1210                1215    
Asn Ser Ile Thr Phe Ser Ser Thr Asp Pro Gln Asp Arg Arg Trp Thr
            1220                1225                1230        
Asn Pro Asp Gly Thr Thr Ser Lys Ile Phe Gly Phe Val Ala Lys Lys
        1235                1240                1245            
Pro Gly Ser Pro Trp Glu Asn Val Cys His Leu Phe Ala Glu Leu Asp
    1250                1255                1260                
Pro Asp Gln Pro Ala Gly Ala Ile Val Thr Phe Ile Thr Lys Val Leu
1265                1270                1275                1280
Leu Gly Gln Arg Lys
                1285


<210> 5700
<211> 949
<212> PRT
<213> Homo sapiens

<400> 5700
Val Met Val Thr Cys Tyr His Lys Gly Gly Arg Gly Thr Asp Arg Thr
 1               5                  10                  15      
Leu Val Phe Arg Val Gln Phe His Thr Cys Thr Ile His Gly Pro Gln
            20                  25                  30          
Leu Thr Phe Pro Lys Asp Gln Leu Asp Glu Ala Trp Thr Asp Glu Arg
        35                  40                  45              
Phe Pro Phe Gln Ala Ser Val Glu Phe Val Phe Ser Ser Ser Pro Glu
    50                  55                  60                  
Lys Ile Lys Gly Ser Thr Pro Arg Asn Asp Pro Ser Val Ser Val Asp
65                  70                  75                  80  
Tyr Asn Thr Thr Glu Pro Ala Val Arg Trp Asp Ser Tyr Glu Asn Phe
                85                  90                  95      
Asn Gln His His Glu Asp Ser Val Asp Gly Ser Leu Thr His Thr Arg
            100                 105                 110         
Gly Pro Leu Asp Gly Ser Pro Tyr Ala Gln Val Gln Arg Pro Pro Arg
        115                 120                 125             
Gln Thr Pro Pro Ala Pro Ser Pro Glu Pro Pro Pro Pro Pro Met Leu
    130                 135                 140                 
Ser Val Ser Ser Asp Ser Gly His Ser Ser Thr Leu Thr Thr Glu Pro
145                 150                 155                 160 
Ala Ala Glu Ser Pro Gly Arg Pro Pro Pro Thr Ala Ala Glu Arg Gln
                165                 170                 175     
Glu Leu Asp Arg Leu Leu Gly Gly Cys Gly Val Ala Ser Gly Gly Arg
            180                 185                 190         
Gly Ala Gly Arg Glu Thr Ala Ile Leu Asp Asp Glu Glu Gln Pro Thr
        195                 200                 205             
Val Gly Gly Gly Pro His Leu Gly Val Tyr Pro Gly His Arg Pro Gly
    210                 215                 220                 
Leu Ser Arg His Cys Ser Cys Arg Gln Gly Tyr Arg Glu Pro Cys Gly
225                 230                 235                 240 
Val Pro Asn Gly Gly Tyr Tyr Arg Pro Glu Gly Thr Leu Glu Arg Arg
                245                 250                 255     
Arg Leu Ala Tyr Gly Gly Tyr Glu Gly Ser Pro Gln Gly Tyr Ala Glu
            260                 265                 270         
Ala Ser Met Glu Lys Arg Arg Leu Cys Arg Ser Leu Ser Glu Gly Leu
        275                 280                 285             
Tyr Pro Tyr Pro Pro Glu Met Gly Lys Pro Ala Thr Gly Asp Phe Gly
    290                 295                 300                 
Tyr Arg Ala Pro Gly Tyr Arg Glu Val Val Ile Leu Glu Asp Pro Gly
305                 310                 315                 320 
Leu Pro Ala Leu Tyr Pro Cys Pro Ala Cys Glu Glu Lys Leu Ala Leu
                325                 330                 335     
Pro Thr Val Ala Leu Tyr Gly Leu Arg Leu Glu Arg Glu Ala Gly Glu
            340                 345                 350         
Gly Trp Ala Ser Glu Ala Gly Lys Pro Leu Leu His Pro Val Arg Pro
        355                 360                 365             
Gly His Pro Leu Pro Leu Leu Leu Pro Ala Cys Gly His His His Ala
    370                 375                 380                 
Pro Met Pro Asp Tyr Ser Cys Leu Lys Pro Pro Lys Ala Gly Glu Glu
385                 390                 395                 400 
Gly His Glu Gly Cys Ser Tyr Thr Met Cys Pro Glu Glu Ser Leu Glu
                405                 410                 415     
Pro Val Ser Trp Arg Glu Gly Pro Ser Gly His Ser Thr Leu Pro Arg
            420                 425                 430         
Ser Pro Arg Asp Ala Gln Cys Ser Ala Ser Ser Glu Leu Ser Gly Pro
        435                 440                 445             
Ser Thr Pro Leu His Thr Ser Ser Pro Val Gln Gly Lys Glu Ser Thr
    450                 455                 460                 
Arg Arg Gln Asp Thr Arg Ser Pro Thr Ser Ala Pro Thr Gln Arg Leu
465                 470                 475                 480 
Ser Pro Gly Glu Ala Leu Pro Pro Val Ser Gln Ala Gly Thr Gly Lys
                485                 490                 495     
Ala Pro Glu Leu Pro Ser Gly Ser Gly Pro Glu Pro Leu Ala Pro Ser
            500                 505                 510         
Pro Val Ser Pro Thr Phe Pro Pro Ser Ser Pro Ser Asp Trp Pro Gln
        515                 520                 525             
Glu Arg Ser Pro Gly Gly His Ser Asp Gly Ala Ser Pro Arg Ser Pro
    530                 535                 540                 
Val Pro Thr Thr Leu Pro Gly Leu Arg His Ala Pro Trp Gln Gly Pro
545                 550                 555                 560 
Arg Gly Pro Pro Asp Ser Pro Asp Gly Ser Pro Leu Thr Pro Val Pro
                565                 570                 575     
Ser Gln Met Pro Trp Leu Val Ala Ser Pro Glu Pro Pro Gln Ser Ser
            580                 585                 590         
Pro Thr Pro Ala Phe Pro Leu Ala Ala Ser Tyr Asp Thr Asn Gly Leu
        595                 600                 605             
Ser Gln Pro Pro Leu Pro Glu Lys Arg His Leu Pro Gly Pro Gly Gln
    610                 615                 620                 
Gln Pro Gly Pro Trp Gly Pro Glu Gln Ala Ser Ser Pro Ala Arg Gly
625                 630                 635                 640 
Ile Ser His His Val Thr Phe Ala Pro Leu Leu Ser Asp Asn Val Pro
                645                 650                 655     
Gln Thr Ser Glu Pro Pro Thr Gln Glu Ser Gln Ser Asn Val Lys Phe
            660                 665                 670         
Val Gln Asp Thr Ser Lys Phe Trp Tyr Lys Pro His Leu Ser Arg Gly
        675                 680                 685             
Gln Ala Ile Ala Leu Leu Lys Asp Lys Asp Pro Gly Ala Phe Leu Ile
    690                 695                 700                 
Arg Asp Ser His Ser Phe Gln Gly Ala Tyr Gly Leu Ala Leu Lys Val
705                 710                 715                 720 
Ala Thr Pro Pro Pro Ser Ala Gln Pro Trp Lys Gly Asp Pro Val Glu
                725                 730                 735     
Gln Leu Val Arg His Phe Leu Ile Glu Thr Gly Pro Lys Gly Val Lys
            740                 745                 750         
Ile Lys Gly Cys Pro Ser Glu Pro Tyr Phe Gly Ser Leu Ser Ala Leu
        755                 760                 765             
Val Ser Gln His Ser Ile Ser Pro Ile Ser Leu Pro Cys Cys Leu Arg
    770                 775                 780                 
Ile Pro Ser Lys Asp Pro Leu Glu Glu Thr Pro Glu Ala Pro Val Pro
785                 790                 795                 800 
Thr Asn Met Ser Thr Ala Ala Asp Leu Leu Arg Gln Gly Ala Ala Cys
                805                 810                 815     
Ser Val Leu Tyr Leu Thr Ser Val Glu Thr Glu Ser Leu Thr Gly Pro
            820                 825                 830         
Gln Ala Val Ala Arg Ala Ser Ser Ala Ala Leu Ser Cys Ser Pro Arg
        835                 840                 845             
Pro Thr Pro Ala Val Val His Phe Lys Val Ser Ala Gln Gly Ile Thr
    850                 855                 860                 
Leu Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Val
865                 870                 875                 880 
Asn Ser Ile Thr Phe Ser Ser Thr Asp Pro Gln Asp Arg Arg Trp Thr
                885                 890                 895     
Asn Pro Asp Gly Thr Thr Ser Lys Ile Phe Gly Phe Val Ala Lys Lys
            900                 905                 910         
Pro Gly Ser Pro Trp Glu Asn Val Cys His Leu Phe Ala Glu Leu Asp
        915                 920                 925             
Pro Asp Gln Pro Ala Gly Ala Ile Val Thr Phe Ile Thr Lys Val Leu
    930                 935                 940                 
Leu Gly Gln Arg Lys
945                 


<210> 5701
<211> 1409
<212> PRT
<213> Homo sapiens

<400> 5701
Met Lys Ser Ser Gly Pro Val Glu Arg Leu Leu Arg Ala Leu Gly Arg
 1               5                  10                  15      
Arg Asp Ser Ser Arg Ala Ala Ser Arg Pro Arg Lys Ala Glu Pro His
            20                  25                  30          
Ser Phe Arg Glu Lys Val Phe Arg Lys Lys Pro Pro Val Cys Ala Val
        35                  40                  45              
Cys Lys Val Thr Ile Asp Gly Thr Gly Val Ser Cys Arg Val Cys Lys
    50                  55                  60                  
Val Ala Thr His Arg Lys Cys Glu Ala Lys Val Thr Ser Ala Cys Gln
65                  70                  75                  80  
Ala Leu Pro Pro Val Glu Leu Arg Arg Asn Thr Ala Pro Val Arg Arg
                85                  90                  95      
Ile Glu His Leu Gly Ser Thr Lys Ser Leu Asn His Ser Lys Gln Arg
            100                 105                 110         
Ser Thr Leu Pro Arg Ser Phe Ser Leu Asp Pro Leu Met Glu Arg Arg
        115                 120                 125             
Trp Asp Leu Asp Leu Thr Tyr Val Thr Glu Arg Ile Leu Ala Ala Ala
    130                 135                 140                 
Phe Pro Ala Arg Pro Asp Glu Gln Arg His Arg Gly His Leu Arg Glu
145                 150                 155                 160 
Leu Ala His Val Leu Gln Ser Lys His Arg Asp Lys Tyr Leu Leu Phe
                165                 170                 175     
Asn Leu Ser Glu Lys Arg His Asp Leu Thr Arg Leu Asn Pro Lys Val
            180                 185                 190         
Gln Asp Phe Gly Trp Pro Glu Leu His Ala Pro Pro Leu Asp Lys Leu
        195                 200                 205             
Cys Ser Ile Cys Lys Ala Met Glu Thr Trp Leu Ser Ala Asp Pro Gln
    210                 215                 220                 
His Val Val Val Leu Tyr Cys Lys Gly Asn Lys Gly Lys Leu Gly Val
225                 230                 235                 240 
Ile Val Ser Ala Tyr Met His Tyr Ser Lys Ile Ser Ala Gly Ala Asp
                245                 250                 255     
Gln Ala Leu Ala Thr Leu Thr Met Arg Lys Phe Cys Glu Asp Lys Val
            260                 265                 270         
Ala Thr Glu Leu Gln Pro Ser Gln Arg Arg Tyr Ile Ser Tyr Phe Ser
        275                 280                 285             
Gly Leu Leu Ser Gly Ser Ile Arg Met Asn Ser Ser Pro Leu Phe Leu
    290                 295                 300                 
His Tyr Val Leu Ile Pro Met Leu Pro Ala Phe Glu Pro Gly Thr Gly
305                 310                 315                 320 
Phe Gln Pro Phe Leu Lys Ile Tyr Gln Ser Met Gln Leu Val Tyr Thr
                325                 330                 335     
Ser Gly Val Tyr His Ile Ala Gly Pro Gly Pro Gln Gln Leu Cys Ile
            340                 345                 350         
Ser Leu Glu Pro Ala Leu Leu Leu Lys Gly Asp Val Met Val Thr Cys
        355                 360                 365             
Tyr His Lys Gly Gly Arg Gly Thr Asp Arg Thr Leu Val Phe Arg Val
    370                 375                 380                 
Gln Phe His Thr Cys Thr Ile His Gly Pro Gln Leu Thr Phe Pro Lys
385                 390                 395                 400 
Asp Gln Leu Asp Glu Ala Trp Thr Asp Glu Arg Phe Pro Phe Gln Ala
                405                 410                 415     
Ser Val Glu Phe Val Phe Ser Ser Ser Pro Glu Lys Ile Lys Gly Ser
            420                 425                 430         
Thr Pro Arg Asn Asp Pro Ser Val Ser Val Asp Tyr Asn Thr Thr Glu
        435                 440                 445             
Pro Ala Val Arg Trp Asp Ser Tyr Glu Asn Phe Asn Gln His His Glu
    450                 455                 460                 
Asp Ser Val Asp Gly Ser Leu Thr His Thr Arg Gly Pro Leu Asp Gly
465                 470                 475                 480 
Ser Pro Tyr Ala Gln Val Gln Arg Pro Pro Arg Gln Thr Pro Pro Ala
                485                 490                 495     
Pro Ser Pro Glu Pro Pro Pro Pro Pro Met Leu Ser Val Ser Ser Asp
            500                 505                 510         
Ser Gly His Ser Ser Thr Leu Thr Thr Glu Pro Ala Ala Glu Ser Pro
        515                 520                 525             
Gly Arg Pro Pro Pro Thr Ala Ala Glu Arg Gln Glu Leu Asp Arg Leu
    530                 535                 540                 
Leu Gly Gly Cys Gly Val Ala Ser Gly Gly Arg Gly Ala Gly Arg Glu
545                 550                 555                 560 
Thr Ala Ile Leu Asp Asp Glu Glu Gln Pro Thr Val Gly Gly Gly Pro
                565                 570                 575     
His Leu Gly Val Tyr Pro Gly His Arg Pro Gly Leu Ser Arg His Cys
            580                 585                 590         
Ser Cys Arg Gln Gly Tyr Arg Glu Pro Cys Gly Val Pro Asn Gly Gly
        595                 600                 605             
Tyr Tyr Arg Pro Glu Gly Thr Leu Glu Arg Arg Arg Leu Ala Tyr Gly
    610                 615                 620                 
Gly Tyr Glu Gly Ser Pro Gln Gly Tyr Ala Glu Ala Ser Met Glu Lys
625                 630                 635                 640 
Arg Arg Leu Cys Arg Ser Leu Ser Glu Gly Leu Tyr Pro Tyr Pro Pro
                645                 650                 655     
Glu Met Gly Lys Pro Ala Thr Gly Asp Phe Gly Tyr Arg Ala Pro Gly
            660                 665                 670         
Tyr Arg Glu Val Val Ile Leu Glu Asp Pro Gly Leu Pro Ala Leu Tyr
        675                 680                 685             
Pro Cys Pro Ala Cys Glu Glu Lys Leu Ala Leu Pro Thr Ala Ala Leu
    690                 695                 700                 
Tyr Gly Leu Arg Leu Glu Arg Glu Ala Gly Glu Gly Trp Ala Ser Glu
705                 710                 715                 720 
Ala Gly Lys Pro Leu Leu His Pro Val Arg Pro Gly His Pro Leu Pro
                725                 730                 735     
Leu Leu Leu Pro Ala Cys Gly His His His Ala Pro Met Pro Asp Tyr
            740                 745                 750         
Ser Cys Leu Lys Pro Pro Lys Ala Gly Glu Glu Gly His Glu Gly Cys
        755                 760                 765             
Ser Tyr Thr Met Cys Pro Glu Gly Arg Tyr Gly His Pro Gly Tyr Pro
    770                 775                 780                 
Ala Leu Val Thr Tyr Ser Tyr Gly Gly Ala Val Pro Ser Tyr Cys Pro
785                 790                 795                 800 
Ala Tyr Gly Arg Val Pro His Ser Cys Gly Ser Pro Gly Glu Gly Arg
                805                 810                 815     
Gly Tyr Pro Ser Pro Gly Ala His Ser Pro Arg Ala Gly Ser Ile Ser
            820                 825                 830         
Pro Gly Ser Pro Pro Tyr Pro Gln Ser Arg Lys Leu Ser Tyr Glu Ile
        835                 840                 845             
Pro Thr Glu Glu Gly Gly Asp Arg Tyr Pro Leu Pro Gly His Leu Ala
    850                 855                 860                 
Ser Ala Gly Pro Leu Ala Ser Ala Glu Ser Leu Glu Pro Val Ser Trp
865                 870                 875                 880 
Arg Glu Gly Pro Ser Gly His Ser Thr Leu Pro Arg Ser Pro Arg Asp
                885                 890                 895     
Ala Pro Cys Ser Ala Ser Ser Glu Leu Ser Gly Pro Ser Thr Pro Leu
            900                 905                 910         
His Thr Ser Ser Pro Val Gln Gly Lys Glu Ser Thr Arg Arg Gln Asp
        915                 920                 925             
Thr Arg Ser Pro Thr Ser Ala Pro Thr Gln Arg Leu Ser Pro Gly Glu
    930                 935                 940                 
Ala Leu Pro Pro Val Ser Gln Ala Gly Thr Gly Lys Ala Pro Glu Leu
945                 950                 955                 960 
Pro Ser Gly Ser Gly Pro Glu Pro Leu Ala Pro Ser Pro Val Ser Pro
                965                 970                 975     
Thr Phe Pro Pro Ser Ser Pro Ser Asp Trp Pro Gln Glu Arg Ser Pro
            980                 985                 990         
Gly Gly His Ser Asp Gly Ala Ser Pro Arg Ser Pro Val Pro Thr Thr
        995                 1000                1005            
Leu Pro Gly Leu Arg His Ala Pro Trp Gln Gly Pro Arg Gly Pro Pro
    1010                1015                1020                
Asp Ser Pro Asp Gly Ser Pro Leu Thr Pro Val Pro Ser Gln Met Pro
1025                1030                1035                1040
Trp Leu Val Ala Ser Pro Glu Pro Pro Gln Ser Ser Pro Thr Pro Ala
                1045                1050                1055    
Phe Pro Leu Ala Ala Ser Tyr Asp Thr Asn Gly Leu Ser Gln Pro Pro
            1060                1065                1070        
Leu Pro Glu Lys Arg His Leu Pro Gly Pro Gly Gln Gln Pro Gly Pro
        1075                1080                1085            
Trp Gly Pro Glu Gln Ala Ser Ser Pro Ala Arg Gly Ile Ser His His
    1090                1095                1100                
Val Thr Phe Ala Pro Leu Leu Ser Asp Asn Val Pro Gln Thr Pro Glu
1105                1110                1115                1120
Pro Pro Thr Gln Glu Ser Gln Ser Asn Val Lys Phe Val Gln Asp Thr
                1125                1130                1135    
Ser Lys Phe Trp Tyr Lys Pro His Leu Ser Arg Asp Gln Ala Ile Ala
            1140                1145                1150        
Leu Leu Lys Asp Lys Asp Pro Gly Ala Phe Leu Ile Arg Asp Ser His
        1155                1160                1165            
Ser Phe Gln Gly Ala Tyr Gly Leu Ala Leu Lys Val Ala Thr Pro Pro
    1170                1175                1180                
Pro Ser Ala Gln Pro Trp Lys Gly Asp Pro Val Glu Gln Leu Val Arg
1185                1190                1195                1200
His Phe Leu Ile Glu Thr Gly Pro Lys Gly Val Lys Ile Lys Gly Cys
                1205                1210                1215    
Pro Ser Glu Pro Tyr Phe Gly Ser Leu Ser Ala Leu Val Ser Gln His
            1220                1225                1230        
Ser Ile Ser Pro Ile Ser Leu Pro Cys Cys Leu Arg Ile Leu Ser Lys
        1235                1240                1245            
Asp Pro Leu Glu Glu Thr Pro Glu Ala Pro Val Pro Thr Asn Met Ser
    1250                1255                1260                
Thr Ala Ala Asp Leu Leu Arg Gln Gly Ala Ala Cys Ser Val Leu Tyr
1265                1270                1275                1280
Leu Thr Ser Val Glu Thr Glu Ser Leu Thr Gly Pro Gln Ala Val Ala
                1285                1290                1295    
Arg Ala Ser Ser Ala Ala Leu Ser Cys Ser Pro Arg Pro Thr Pro Ala
            1300                1305                1310        
Val Val His Phe Lys Val Ser Ala Gln Gly Ile Thr Leu Thr Asp Asn
        1315                1320                1325            
Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Val Asn Ser Ile Thr
    1330                1335                1340                
Phe Ser Ser Thr Asp Pro Gln Asp Arg Arg Trp Thr Asn Pro Asp Gly
1345                1350                1355                1360
Thr Thr Ser Lys Ile Phe Gly Phe Val Ala Lys Lys Pro Gly Ser Pro
                1365                1370                1375    
Trp Glu Asn Val Cys His Leu Phe Ala Glu Leu Asp Pro Asp Gln Pro
            1380                1385                1390        
Ala Gly Ala Ile Val Thr Phe Ile Thr Lys Val Leu Leu Gly Gln Arg
        1395                1400                1405            
Lys
    


<210> 5702
<211> 399
<212> PRT
<213> Homo sapiens

<400> 5702
Met Ser Leu Gln Tyr Gly Ala Glu Glu Thr Pro Leu Ala Gly Ser Tyr
 1               5                  10                  15      
Gly Ala Ala Asp Ser Phe Pro Lys Asp Phe Gly Tyr Gly Val Glu Glu
            20                  25                  30          
Glu Glu Glu Glu Ala Ala Ala Ala Gly Gly Gly Val Gly Ala Gly Ala
        35                  40                  45              
Gly Gly Gly Cys Gly Pro Gly Gly Ala Asp Ser Ser Lys Pro Arg Ile
    50                  55                  60                  
Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser Ile Gln Lys Val
65                  70                  75                  80  
Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe Leu Glu Ser Thr
                85                  90                  95      
Asn Lys Ile Tyr Lys Asp Asp Ile Ser Asn Ser Ser Phe Val Asn Phe
            100                 105                 110         
Gln Ile Trp Asp Phe Pro Gly Gln Met Asp Phe Phe Asp Pro Thr Phe
        115                 120                 125             
Asp Tyr Glu Met Ile Phe Arg Gly Thr Gly Ala Leu Ile Tyr Val Ile
    130                 135                 140                 
Asp Ala Gln Asp Asp Tyr Met Glu Ala Leu Thr Arg Leu His Ile Thr
145                 150                 155                 160 
Val Ser Lys Ala Tyr Lys Val Asn Pro Asp Met Asn Phe Glu Val Phe
                165                 170                 175     
Ile His Lys Val Asp Gly Leu Ser Asp Asp His Lys Ile Glu Thr Gln
            180                 185                 190         
Arg Asp Ile His Gln Arg Ala Asn Asp Asp Leu Ala Asp Ser Gly Leu
        195                 200                 205             
Glu Lys Leu His Leu Ser Phe Tyr Leu Thr Ser Ile Tyr Asp His Ser
    210                 215                 220                 
Ile Phe Glu Ala Phe Ser Lys Val Val Gln Lys Leu Ile Pro Gln Leu
225                 230                 235                 240 
Pro Thr Leu Glu Asn Leu Leu Asn Ile Phe Ile Ser Asn Ser Gly Ile
                245                 250                 255     
Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys Ile Tyr Ile Ala Thr
            260                 265                 270         
Asp Ser Ser Pro Val Asp Met Gln Ser Tyr Glu Leu Cys Cys Asp Met
        275                 280                 285             
Ile Asp Val Val Ile Asp Val Ser Cys Ile Tyr Gly Leu Lys Glu Asp
    290                 295                 300                 
Gly Ser Gly Ser Ala Tyr Asp Lys Glu Ser Met Ala Ile Ile Lys Leu
305                 310                 315                 320 
Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr Lys Phe Leu Ala
                325                 330                 335     
Leu Val Cys Ile Leu Arg Glu Glu Ser Phe Glu Arg Lys Gly Leu Ile
            340                 345                 350         
Asp Tyr Asn Phe His Cys Phe Arg Lys Ala Ile His Glu Val Phe Glu
        355                 360                 365             
Val Gly Val Thr Ser His Arg Ser Cys Gly His Gln Thr Ser Ala Ser
    370                 375                 380                 
Ser Leu Lys Ala Leu Thr His Asn Gly Thr Pro Arg Asn Ala Ile
385                 390                 395                 


<210> 5703
<211> 399
<212> PRT
<213> Homo sapiens

<400> 5703
Met Ser Leu Gln Tyr Gly Ala Glu Glu Thr Pro Leu Ala Gly Ser Tyr
 1               5                  10                  15      
Gly Ala Ala Asp Ser Phe Pro Lys Asp Phe Gly Tyr Gly Val Glu Glu
            20                  25                  30          
Glu Glu Glu Glu Ala Ala Ala Ala Gly Gly Gly Val Gly Ala Gly Ala
        35                  40                  45              
Gly Gly Gly Cys Gly Pro Gly Gly Ala Asp Ser Ser Lys Pro Arg Ile
    50                  55                  60                  
Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser Ile Gln Lys Val
65                  70                  75                  80  
Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe Leu Glu Ser Thr
                85                  90                  95      
Asn Lys Ile Tyr Lys Asp Asp Ile Ser Asn Ser Ser Phe Val Asn Phe
            100                 105                 110         
Gln Ile Trp Asp Phe Pro Gly Gln Met Asp Phe Phe Asp Pro Thr Phe
        115                 120                 125             
Asp Tyr Glu Met Ile Phe Arg Gly Thr Gly Ala Leu Ile Tyr Val Ile
    130                 135                 140                 
Asp Ala Gln Asp Asp Tyr Met Glu Ala Leu Thr Arg Leu His Ile Thr
145                 150                 155                 160 
Val Ser Lys Ala Tyr Lys Val Asn Pro Asp Met Asn Phe Glu Val Phe
                165                 170                 175     
Ile His Lys Val Asp Gly Leu Ser Asp Asp His Lys Ile Glu Thr Gln
            180                 185                 190         
Arg Asp Ile His Gln Arg Ala Asn Asp Asp Leu Ala Asp Ala Gly Leu
        195                 200                 205             
Glu Lys Leu His Leu Ser Phe Tyr Leu Thr Ser Ile Tyr Asp His Ser
    210                 215                 220                 
Ile Phe Glu Ala Phe Ser Lys Val Val Gln Lys Leu Ile Pro Gln Leu
225                 230                 235                 240 
Pro Thr Leu Glu Asn Leu Leu Asn Ile Phe Ile Ser Asn Ser Gly Ile
                245                 250                 255     
Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys Ile Tyr Ile Ala Thr
            260                 265                 270         
Asp Ser Ser Pro Val Asp Met Gln Ser Tyr Glu Leu Cys Cys Asp Met
        275                 280                 285             
Ile Asp Val Val Ile Asp Val Ser Cys Ile Tyr Gly Leu Lys Glu Asp
    290                 295                 300                 
Gly Ser Gly Ser Ala Tyr Asp Lys Glu Ser Met Ala Ile Ile Lys Leu
305                 310                 315                 320 
Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr Lys Phe Leu Ala
                325                 330                 335     
Leu Val Cys Ile Leu Arg Glu Glu Ser Phe Glu Arg Lys Gly Leu Ile
            340                 345                 350         
Asp Tyr Asn Phe His Cys Phe Arg Lys Ala Ile His Glu Val Phe Glu
        355                 360                 365             
Val Gly Val Thr Ser His Arg Ser Cys Gly His Gln Thr Ser Ala Ser
    370                 375                 380                 
Ser Leu Lys Ala Leu Thr His Asn Gly Thr Pro Arg Asn Ala Ile
385                 390                 395                 


<210> 5704
<211> 270
<212> PRT
<213> Homo sapiens

<400> 5704
Met Asp Ser Leu Glu Trp Asn Trp Ala Leu Val Tyr Glu Leu Ser Gly
 1               5                  10                  15      
Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val Ala
            20                  25                  30          
Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile Ile
        35                  40                  45              
Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser Ile
    50                  55                  60                  
Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala Gly
65                  70                  75                  80  
Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu Arg Asp Tyr
                85                  90                  95      
Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro Tyr
            100                 105                 110         
Phe Phe His Ala Gly Gly Thr Asp Trp Gln Gly Thr Ser Ile Asp Arg
        115                 120                 125             
Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His Gly
    130                 135                 140                 
Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys Lys
145                 150                 155                 160 
Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys Leu
                165                 170                 175     
Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr Gly
            180                 185                 190         
His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala Lys
        195                 200                 205             
Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly Met
    210                 215                 220                 
Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile Lys
225                 230                 235                 240 
Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile Trp
                245                 250                 255     
Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys
            260                 265                 270 


<210> 5705
<211> 511
<212> PRT
<213> Homo sapiens

<400> 5705
Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu
 1               5                  10                  15      
Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu
            20                  25                  30          
Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly
        35                  40                  45              
Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met
    50                  55                  60                  
Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe
65                  70                  75                  80  
Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser
                85                  90                  95      
Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His
            100                 105                 110         
Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val
        115                 120                 125             
Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met
    130                 135                 140                 
Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser
145                 150                 155                 160 
Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr
                165                 170                 175     
Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His
            180                 185                 190         
Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu
        195                 200                 205             
Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe
    210                 215                 220                 
Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val
225                 230                 235                 240 
Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser
                245                 250                 255     
Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val
            260                 265                 270         
Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile
        275                 280                 285             
Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser
    290                 295                 300                 
Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala
305                 310                 315                 320 
Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu Arg Asp
                325                 330                 335     
Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro
            340                 345                 350         
Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp
        355                 360                 365             
Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His
    370                 375                 380                 
Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys
385                 390                 395                 400 
Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys
                405                 410                 415     
Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr
            420                 425                 430         
Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala
        435                 440                 445             
Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly
    450                 455                 460                 
Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile
465                 470                 475                 480 
Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile
                485                 490                 495     
Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys
            500                 505                 510     


<210> 5706
<211> 895
<212> PRT
<213> Homo sapiens

<400> 5706
Met Asn Lys Ser Glu Asn Leu Leu Phe Ala Gly Ser Ser Leu Ala Ser
 1               5                  10                  15      
Gln Val His Ala Ala Ala Val Asn Gly Asp Lys Gly Ala Leu Gln Arg
            20                  25                  30          
Leu Ile Val Gly Asn Ser Ala Leu Lys Asp Lys Glu Asp Gln Phe Gly
        35                  40                  45              
Arg Thr Pro Leu Met Tyr Cys Val Leu Ala Asp Arg Leu Asp Cys Ala
    50                  55                  60                  
Asp Ala Leu Leu Lys Ala Gly Ala Asp Val Asn Lys Thr Asp His Ser
65                  70                  75                  80  
Gln Arg Thr Ala Leu His Leu Ala Ala Gln Lys Gly Asn Tyr Arg Phe
                85                  90                  95      
Met Lys Leu Leu Leu Thr Arg Arg Ala Asn Trp Met Gln Lys Asp Leu
            100                 105                 110         
Glu Glu Met Thr Pro Leu His Leu Thr Thr Arg His Arg Ser Pro Lys
        115                 120                 125             
Cys Leu Ala Leu Leu Leu Lys Phe Met Ala Pro Gly Glu Val Asp Thr
    130                 135                 140                 
Gln Asp Lys Asn Lys Gln Thr Ala Leu His Trp Ser Ala Tyr Tyr Asn
145                 150                 155                 160 
Asn Pro Glu His Val Lys Leu Leu Ile Lys His Asp Ser Asn Ile Gly
                165                 170                 175     
Ile Pro Asp Val Glu Gly Lys Ile Pro Leu His Trp Ala Ala Asn His
            180                 185                 190         
Lys Asp Pro Ser Ala Val His Thr Val Arg Cys Ile Leu Asp Ala Ala
        195                 200                 205             
Pro Thr Glu Ser Leu Leu Asn Trp Gln Asp Tyr Glu Gly Arg Thr Pro
    210                 215                 220                 
Leu His Phe Ala Val Ala Asp Gly Asn Val Thr Val Val Asp Val Leu
225                 230                 235                 240 
Thr Ser Tyr Glu Ser Cys Asn Ile Thr Ser Tyr Asp Asn Leu Phe Arg
                245                 250                 255     
Thr Pro Leu His Trp Ala Ala Leu Leu Gly His Ala Gln Ile Val His
            260                 265                 270         
Leu Leu Leu Glu Arg Asn Lys Ser Gly Thr Ile Pro Ser Asp Ser Gln
        275                 280                 285             
Gly Ala Thr Pro Leu His Tyr Ala Ala Gln Ser Asn Phe Ala Glu Thr
    290                 295                 300                 
Val Lys Val Phe Leu Lys His Pro Ser Val Lys Asp Asp Ser Asp Leu
305                 310                 315                 320 
Glu Gly Arg Thr Ser Phe Met Trp Ala Ala Gly Lys Gly Ser Asp Asp
                325                 330                 335     
Val Leu Arg Thr Met Leu Ser Leu Lys Ser Asp Ile Asp Ile Asn Met
            340                 345                 350         
Ala Asp Lys Tyr Gly Gly Thr Ala Leu His Ala Ala Ala Leu Ser Gly
        355                 360                 365             
His Val Ser Thr Val Lys Leu Leu Leu Glu Asn Asn Ala Gln Val Asp
    370                 375                 380                 
Ala Thr Asp Val Met Lys His Thr Pro Leu Phe Arg Ala Cys Glu Met
385                 390                 395                 400 
Gly His Lys Asp Val Ile Gln Thr Leu Ile Lys Gly Gly Ala Arg Val
                405                 410                 415     
Asp Leu Val Asp Gln Asp Gly His Ser Leu Leu His Trp Ala Ala Leu
            420                 425                 430         
Gly Gly Asn Ala Asp Val Cys Gln Ile Leu Ile Glu Asn Lys Ile Asn
        435                 440                 445             
Pro Asn Val Gln Asp Tyr Ala Gly Arg Thr Pro Leu Gln Cys Ala Ala
    450                 455                 460                 
Tyr Gly Gly Tyr Ile Asn Cys Met Ala Val Leu Met Glu Asn Asn Ala
465                 470                 475                 480 
Asp Pro Asn Ile Gln Asp Lys Glu Gly Arg Thr Ala Leu His Trp Ser
                485                 490                 495     
Cys Asn Asn Gly Tyr Leu Asp Ala Ile Lys Leu Leu Leu Asp Phe Ala
            500                 505                 510         
Ala Phe Pro Asn Gln Met Glu Asn Asn Glu Glu Arg Tyr Thr Pro Leu
        515                 520                 525             
Asp Tyr Ala Leu Leu Gly Glu Arg His Glu Val Ile Gln Phe Met Leu
    530                 535                 540                 
Glu His Gly Ala Leu Ser Ile Ala Ala Ile Gln Asp Ile Ala Ala Phe
545                 550                 555                 560 
Lys Ile Gln Ala Val Tyr Lys Gly Tyr Lys Val Arg Lys Ala Phe Arg
                565                 570                 575     
Asp Arg Lys Asn Leu Leu Met Lys His Glu Gln Leu Arg Lys Asp Ala
            580                 585                 590         
Ala Ala Lys Lys Arg Glu Glu Glu Asn Lys Arg Lys Glu Ala Glu Gln
        595                 600                 605             
Gln Lys Gly Arg Arg Ser Pro Asp Ser Cys Arg Pro Gln Ala Leu Pro
    610                 615                 620                 
Cys Leu Pro Ser Thr Gln Asp Val Pro Ser Arg Gln Ser Arg Ala Pro
625                 630                 635                 640 
Ser Lys Gln Pro Pro Ala Gly Asn Val Ala Gln Gly Pro Glu Pro Arg
                645                 650                 655     
Asp Ser Arg Gly Ser Pro Gly Gly Ser Leu Gly Gly Ala Leu Gln Lys
            660                 665                 670         
Glu Gln His Val Ser Ser Asp Leu Gln Gly Thr Asn Ser Arg Arg Pro
        675                 680                 685             
Asn Glu Thr Ala Arg Glu His Ser Lys Gly Gln Ser Ala Cys Val His
    690                 695                 700                 
Phe Arg Pro Asn Glu Gly Ser Asp Gly Ser Arg His Pro Gly Val Pro
705                 710                 715                 720 
Ser Val Glu Lys Ser Arg Glu Leu Arg Leu Gln Ile Ile Gln Arg Glu
                725                 730                 735     
Arg Arg Arg Lys Glu Leu Phe Arg Lys Lys Asn Lys Ala Ala Ala Val
            740                 745                 750         
Ile Gln Arg Ala Trp Arg Ser Tyr Gln Leu Arg Lys His Leu Ser His
        755                 760                 765             
Leu Arg His Met Lys Gln Leu Gly Ala Gly Asp Val Asp Arg Trp Arg
    770                 775                 780                 
Gln Glu Ser Thr Ala Leu Leu Leu Gln Val Trp Arg Lys Glu Leu Glu
785                 790                 795                 800 
Leu Lys Phe Pro Gln Thr Thr Ala Val Ser Lys Ala Pro Lys Ser Pro
                805                 810                 815     
Ser Lys Gly Thr Ser Gly Thr Lys Ser Thr Lys His Ser Val Leu Lys
            820                 825                 830         
Gln Ile Tyr Gly Cys Ser His Glu Gly Lys Ile His His Pro Thr Arg
        835                 840                 845             
Ser Val Lys Ala Ser Ser Val Leu Arg Leu Asn Ser Val Ser Asn Leu
    850                 855                 860                 
Gln Cys Ile His Leu Leu Glu Asn Ser Gly Arg Ser Lys Asn Phe Ser
865                 870                 875                 880 
Tyr Asn Leu Gln Ser Ala Thr Gln Pro Lys Asn Lys Thr Lys Pro
                885                 890                 895 


<210> 5707
<211> 1065
<212> PRT
<213> Homo sapiens

<400> 5707
Met Asn Lys Ser Glu Asn Leu Leu Phe Ala Gly Ser Ser Leu Ala Ser
 1               5                  10                  15      
Gln Val His Ala Ala Ala Val Asn Gly Asp Lys Gly Ala Leu Gln Arg
            20                  25                  30          
Leu Ile Val Gly Asn Ser Ala Leu Lys Asp Lys Glu Asp Gln Phe Gly
        35                  40                  45              
Arg Thr Pro Leu Met Tyr Cys Val Leu Ala Asp Arg Leu Asp Cys Ala
    50                  55                  60                  
Asp Ala Leu Leu Lys Ala Gly Ala Asp Val Asn Lys Thr Asp His Ser
65                  70                  75                  80  
Gln Arg Thr Ala Leu His Leu Ala Ala Gln Lys Gly Asn Tyr Arg Phe
                85                  90                  95      
Met Lys Leu Leu Leu Thr Arg Arg Ala Asn Trp Met Gln Lys Asp Leu
            100                 105                 110         
Glu Glu Met Thr Pro Leu His Leu Thr Thr Arg His Arg Ser Pro Lys
        115                 120                 125             
Cys Leu Ala Leu Leu Leu Lys Phe Met Ala Pro Gly Glu Val Asp Thr
    130                 135                 140                 
Gln Asp Lys Asn Lys Gln Thr Ala Leu His Trp Ser Ala Tyr Tyr Asn
145                 150                 155                 160 
Asn Pro Glu His Val Lys Leu Leu Ile Lys His Asp Ser Asn Ile Gly
                165                 170                 175     
Ile Pro Asp Val Glu Gly Lys Ile Pro Leu His Trp Ala Ala Asn His
            180                 185                 190         
Lys Asp Pro Ser Ala Val His Thr Val Arg Cys Ile Leu Asp Ala Ala
        195                 200                 205             
Pro Thr Glu Ser Leu Leu Asn Trp Gln Asp Tyr Glu Gly Arg Thr Pro
    210                 215                 220                 
Leu His Phe Ala Val Ala Asp Gly Asn Val Thr Val Val Asp Val Leu
225                 230                 235                 240 
Thr Ser Tyr Glu Ser Cys Asn Ile Thr Ser Tyr Asp Asn Leu Phe Arg
                245                 250                 255     
Thr Pro Leu His Trp Ala Ala Leu Leu Gly His Ala Gln Ile Val His
            260                 265                 270         
Leu Leu Leu Glu Arg Asn Lys Ser Gly Thr Ile Pro Ser Asp Ser Gln
        275                 280                 285             
Gly Ala Thr Pro Leu His Tyr Ala Ala Gln Ser Asn Phe Ala Glu Thr
    290                 295                 300                 
Val Lys Val Phe Leu Lys His Pro Ser Val Lys Asp Asp Ser Asp Leu
305                 310                 315                 320 
Glu Gly Arg Thr Ser Phe Met Trp Ala Ala Gly Lys Gly Ser Asp Asp
                325                 330                 335     
Val Leu Arg Thr Met Leu Ser Leu Lys Ser Asp Ile Asp Ile Asn Met
            340                 345                 350         
Ala Asp Lys Tyr Gly Gly Thr Ala Leu His Ala Ala Ala Leu Ser Gly
        355                 360                 365             
His Val Ser Thr Val Lys Leu Leu Leu Glu Asn Asn Ala Gln Val Asp
    370                 375                 380                 
Ala Thr Asp Val Met Lys His Thr Pro Leu Phe Arg Ala Cys Glu Met
385                 390                 395                 400 
Gly His Lys Asp Val Ile Gln Thr Leu Ile Lys Gly Gly Ala Arg Val
                405                 410                 415     
Asp Leu Val Asp Gln Asp Gly His Ser Leu Leu His Trp Ala Ala Leu
            420                 425                 430         
Gly Gly Asn Ala Asp Val Cys Gln Ile Leu Ile Glu Asn Lys Ile Asn
        435                 440                 445             
Pro Asn Val Gln Asp Tyr Ala Gly Arg Thr Pro Leu Gln Cys Ala Ala
    450                 455                 460                 
Tyr Gly Gly Tyr Ile Asn Cys Met Ala Val Leu Met Glu Asn Asn Ala
465                 470                 475                 480 
Asp Pro Asn Ile Gln Asp Lys Glu Gly Arg Thr Ala Leu His Trp Ser
                485                 490                 495     
Cys Asn Asn Gly Tyr Leu Asp Ala Ile Lys Leu Leu Leu Asp Phe Ala
            500                 505                 510         
Ala Phe Pro Asn Gln Met Glu Asn Asn Glu Glu Arg Tyr Thr Pro Leu
        515                 520                 525             
Asp Tyr Ala Leu Leu Gly Glu Arg His Glu Val Ile Gln Phe Met Leu
    530                 535                 540                 
Glu His Gly Ala Leu Ser Ile Ala Ala Ile Gln Asp Ile Ala Ala Phe
545                 550                 555                 560 
Lys Ile Gln Ala Val Tyr Lys Gly Tyr Lys Val Arg Lys Ala Phe Arg
                565                 570                 575     
Asp Arg Lys Asn Leu Leu Met Lys His Glu Gln Leu Arg Lys Asp Ala
            580                 585                 590         
Ala Ala Lys Lys Arg Glu Glu Glu Asn Lys Arg Lys Glu Ala Glu Gln
        595                 600                 605             
Gln Lys Gly Arg Arg Ser Pro Asp Ser Cys Arg Pro Gln Ala Leu Pro
    610                 615                 620                 
Cys Leu Pro Ser Thr Gln Asp Val Pro Ser Arg Gln Ser Arg Ala Pro
625                 630                 635                 640 
Ser Lys Gln Pro Pro Ala Gly Asn Val Ala Gln Gly Pro Glu Pro Arg
                645                 650                 655     
Asp Ser Arg Gly Ser Pro Gly Gly Ser Leu Gly Gly Ala Leu Gln Lys
            660                 665                 670         
Glu Gln His Val Ser Ser Asp Leu Gln Gly Thr Asn Ser Arg Arg Pro
        675                 680                 685             
Asn Glu Thr Ala Arg Glu His Ser Lys Gly Gln Ser Ala Cys Val His
    690                 695                 700                 
Phe Arg Pro Asn Glu Gly Ser Asp Gly Ser Arg His Pro Gly Val Pro
705                 710                 715                 720 
Ser Val Glu Lys Ser Arg Gly Glu Thr Ala Gly Asp Glu Arg Cys Ala
                725                 730                 735     
Lys Gly Lys Gly Phe Val Lys Gln Pro Ser Cys Ile Arg Val Ala Gly
            740                 745                 750         
Pro Asp Glu Lys Gly Glu Asp Ser Arg Arg Ala Gly Ala Ser Leu Pro
        755                 760                 765             
Pro His Asp Ser His Trp Lys Pro Ser Arg Arg His Asp Thr Glu Pro
    770                 775                 780                 
Lys Ala Lys Cys Ala Pro Gln Lys Arg Arg Thr Gln Glu Leu Arg Gly
785                 790                 795                 800 
Gly Arg Cys Ser Pro Ala Gly Ser Ser Arg Pro Gly Ser Ala Arg Gly
                805                 810                 815     
Glu Ala Val His Ala Gly Gln Asn Pro Pro His His Arg Thr Pro Arg
            820                 825                 830         
Asn Lys Val Thr Gln Ala Lys Leu Thr Gly Gly Leu Tyr Ser His Leu
        835                 840                 845             
Pro Gln Ser Thr Glu Glu Leu Arg Ser Gly Ala Arg Arg Leu Glu Thr
    850                 855                 860                 
Ser Thr Leu Ser Glu Asp Phe Gln Val Ser Lys Glu Thr Asp Pro Ala
865                 870                 875                 880 
Pro Gly Pro Leu Ser Gly Gln Ser Val Asn Ile Asp Leu Leu Pro Val
                885                 890                 895     
Glu Leu Arg Leu Gln Ile Ile Gln Arg Glu Arg Arg Arg Lys Glu Leu
            900                 905                 910         
Phe Arg Lys Lys Asn Lys Ala Ala Ala Val Ile Gln Arg Ala Trp Arg
        915                 920                 925             
Ser Tyr Gln Leu Arg Lys His Leu Ser His Leu Arg His Met Lys Gln
    930                 935                 940                 
Leu Gly Ala Gly Asp Val Asp Arg Trp Arg Gln Glu Ser Thr Ala Leu
945                 950                 955                 960 
Leu Leu Gln Val Trp Arg Lys Glu Leu Glu Leu Lys Phe Pro Gln Thr
                965                 970                 975     
Thr Ala Val Ser Lys Ala Pro Lys Ser Pro Ser Lys Gly Thr Ser Gly
            980                 985                 990         
Thr Lys Ser Thr Lys His Ser Val Leu Lys Gln Ile Tyr Gly Cys Ser
        995                 1000                1005            
His Glu Gly Lys Ile His His Pro Thr Arg Ser Val Lys Ala Ser Ser
    1010                1015                1020                
Val Leu Arg Leu Asn Ser Val Ser Asn Leu Gln Cys Ile His Leu Leu
1025                1030                1035                1040
Glu Asn Ser Gly Arg Ser Lys Asn Phe Ser Tyr Asn Leu Gln Ser Ala
                1045                1050                1055    
Thr Gln Pro Lys Asn Lys Thr Lys Pro
            1060                1065


<210> 5708
<211> 311
<212> PRT
<213> Homo sapiens

<400> 5708
Met Thr Gly Gly Gly Asn Ile Thr Glu Ile Thr Tyr Phe Ile Leu Leu
 1               5                  10                  15      
Gly Phe Ser Asp Phe Pro Arg Ile Ile Lys Val Leu Phe Thr Ile Phe
            20                  25                  30          
Leu Val Ile Tyr Ile Thr Ser Leu Ala Trp Asn Leu Ser Leu Ile Val
        35                  40                  45              
Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu
    50                  55                  60                  
Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Ile Ser Ser Thr Val Pro
65                  70                  75                  80  
Lys Met Leu Ser Asn Leu Leu Gln Glu Gln Gln Thr Ile Thr Phe Val
                85                  90                  95      
Gly Cys Ile Ile Gln Tyr Phe Ile Phe Ser Thr Met Gly Leu Ser Glu
            100                 105                 110         
Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys
        115                 120                 125             
Asn Pro Leu Leu Tyr Ser Ser Ile Met Ser Pro Thr Leu Cys Val Trp
    130                 135                 140                 
Met Val Leu Gly Ala Tyr Met Thr Gly Leu Thr Ala Ser Leu Phe Gln
145                 150                 155                 160 
Ile Gly Ala Leu Leu Gln Leu His Phe Cys Gly Ser Asn Val Ile Arg
                165                 170                 175     
His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp
            180                 185                 190         
Thr Phe Phe Val Gln Val Met Thr Ala Ile Leu Thr Met Phe Phe Gly
        195                 200                 205             
Ile Ala Ser Ala Leu Val Ile Met Ile Ser Tyr Gly Tyr Ile Gly Ile
    210                 215                 220                 
Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn
225                 230                 235                 240 
Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Gly
                245                 250                 255     
Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp
            260                 265                 270         
Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro
        275                 280                 285             
Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg
    290                 295                 300                 
Leu Gln Lys Arg Lys Cys Cys
305                 310     


<210> 5709
<211> 292
<212> PRT
<213> Homo sapiens

<400> 5709
Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn
 1               5                  10                  15      
Asp His Pro Phe His Gln Gly Pro Pro Pro Ala Gln Pro Leu Ala Gln
            20                  25                  30          
Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu Ser Phe Asn
        35                  40                  45              
Ile Leu Leu Leu Val Val Ile Cys Val Thr Gly Ser Gln Ser Glu Gly
    50                  55                  60                  
His Arg Gly Ala Gln Leu Gln Ala Glu Leu Arg Ser Leu Lys Glu Ala
65                  70                  75                  80  
Phe Ser Asn Phe Ser Ser Ser Thr Leu Thr Glu Val Gln Ala Ile Ser
                85                  90                  95      
Thr His Gly Gly Ser Val Gly Asp Lys Ile Thr Ser Leu Gly Ala Lys
            100                 105                 110         
Leu Glu Lys Gln Gln Gln Asp Leu Lys Ala Asp His Asp Ala Leu Leu
        115                 120                 125             
Phe His Leu Lys His Phe Pro Val Asp Leu Arg Phe Val Ala Cys Gln
    130                 135                 140                 
Met Glu Leu Leu His Ser Asn Gly Ser Gln Arg Thr Cys Cys Pro Val
145                 150                 155                 160 
Asn Trp Val Glu His Gln Gly Ser Cys Tyr Trp Phe Ser His Ser Gly
                165                 170                 175     
Lys Ala Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Glu Asn Ala His
            180                 185                 190         
Leu Val Val Ile Asn Ser Trp Glu Glu Gln Lys Phe Ile Val Gln His
        195                 200                 205             
Thr Asn Pro Phe Asn Thr Trp Ile Gly Leu Thr Asp Ser Asp Gly Ser
    210                 215                 220                 
Trp Lys Trp Val Asp Gly Thr Asp Tyr Arg His Asn Tyr Lys Asn Trp
225                 230                 235                 240 
Ala Val Thr Gln Pro Asp Asn Trp His Gly His Glu Leu Gly Gly Ser
                245                 250                 255     
Glu Asp Cys Val Glu Val Gln Pro Asp Gly Arg Trp Asn Asp Asp Phe
            260                 265                 270         
Cys Leu Gln Val Tyr Arg Trp Val Cys Glu Lys Arg Arg Asn Ala Thr
        275                 280                 285             
Gly Glu Val Ala
    290         


<210> 5710
<211> 287
<212> PRT
<213> Homo sapiens

<400> 5710
Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn
 1               5                  10                  15      
Asp His Pro Phe His Gln Gly Pro Pro Pro Ala Gln Pro Leu Ala Gln
            20                  25                  30          
Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu Ser Phe Asn
        35                  40                  45              
Ile Leu Leu Leu Val Val Ile Cys Val Thr Gly Ser Gln Ser Ala Gln
    50                  55                  60                  
Leu Gln Ala Glu Leu Arg Ser Leu Lys Glu Ala Phe Ser Asn Phe Ser
65                  70                  75                  80  
Ser Ser Thr Leu Thr Glu Val Gln Ala Ile Ser Thr His Gly Gly Ser
                85                  90                  95      
Val Gly Asp Lys Ile Thr Ser Leu Gly Ala Lys Leu Glu Lys Gln Gln
            100                 105                 110         
Gln Asp Leu Lys Ala Asp His Asp Ala Leu Leu Phe His Leu Lys His
        115                 120                 125             
Phe Pro Val Asp Leu Arg Phe Val Ala Cys Gln Met Glu Leu Leu His
    130                 135                 140                 
Ser Asn Gly Ser Gln Arg Thr Cys Cys Pro Val Asn Trp Val Glu His
145                 150                 155                 160 
Gln Gly Ser Cys Tyr Trp Phe Ser His Ser Gly Lys Ala Trp Ala Glu
                165                 170                 175     
Ala Glu Lys Tyr Cys Gln Leu Glu Asn Ala His Leu Val Val Ile Asn
            180                 185                 190         
Ser Trp Glu Glu Gln Lys Phe Ile Val Gln His Thr Asn Pro Phe Asn
        195                 200                 205             
Thr Trp Ile Gly Leu Thr Asp Ser Asp Gly Ser Trp Lys Trp Val Asp
    210                 215                 220                 
Gly Thr Asp Tyr Arg His Asn Tyr Lys Asn Trp Ala Val Thr Gln Pro
225                 230                 235                 240 
Asp Asn Trp His Gly His Glu Leu Gly Gly Ser Glu Asp Cys Val Glu
                245                 250                 255     
Val Gln Pro Asp Gly Arg Trp Asn Asp Asp Phe Cys Leu Gln Val Tyr
            260                 265                 270         
Arg Trp Val Cys Glu Lys Arg Arg Asn Ala Thr Gly Glu Val Ala
        275                 280                 285         


<210> 5711
<211> 311
<212> PRT
<213> Homo sapiens

<400> 5711
Met Ala Lys Asp Phe Gln Asp Ile Gln Gln Leu Ser Ser Glu Glu Asn
 1               5                  10                  15      
Asp His Pro Phe His Gln Gly Glu Gly Pro Gly Thr Arg Arg Leu Asn
            20                  25                  30          
Pro Arg Arg Gly Asn Pro Phe Leu Lys Gly Pro Pro Pro Ala Gln Pro
        35                  40                  45              
Leu Ala Gln Arg Leu Cys Ser Met Val Cys Phe Ser Leu Leu Ala Leu
    50                  55                  60                  
Ser Phe Asn Ile Leu Leu Leu Val Val Ile Cys Val Thr Gly Ser Gln
65                  70                  75                  80  
Ser Glu Gly His Arg Gly Ala Gln Leu Gln Ala Glu Leu Arg Ser Leu
                85                  90                  95      
Lys Glu Ala Phe Ser Asn Phe Ser Ser Ser Thr Leu Thr Glu Val Gln
            100                 105                 110         
Ala Ile Ser Thr His Gly Gly Ser Val Gly Asp Lys Ile Thr Ser Leu
        115                 120                 125             
Gly Ala Lys Leu Glu Lys Gln Gln Gln Asp Leu Lys Ala Asp His Asp
    130                 135                 140                 
Ala Leu Leu Phe His Leu Lys His Phe Pro Val Asp Leu Arg Phe Val
145                 150                 155                 160 
Ala Cys Gln Met Glu Leu Leu His Ser Asn Gly Ser Gln Arg Thr Cys
                165                 170                 175     
Cys Pro Val Asn Trp Val Glu His Gln Gly Ser Cys Tyr Trp Phe Ser
            180                 185                 190         
His Ser Gly Lys Ala Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Glu
        195                 200                 205             
Asn Ala His Leu Val Val Ile Asn Ser Trp Glu Glu Gln Lys Phe Ile
    210                 215                 220                 
Val Gln His Thr Asn Pro Phe Asn Thr Trp Ile Gly Leu Thr Asp Ser
225                 230                 235                 240 
Asp Gly Ser Trp Lys Trp Val Asp Gly Thr Asp Tyr Arg His Asn Tyr
                245                 250                 255     
Lys Asn Trp Ala Val Thr Gln Pro Asp Asn Trp His Gly His Glu Leu
            260                 265                 270         
Gly Gly Ser Glu Asp Cys Val Glu Val Gln Pro Asp Gly Arg Trp Asn
        275                 280                 285             
Asp Asp Phe Cys Leu Gln Val Tyr Arg Trp Val Cys Glu Lys Arg Arg
    290                 295                 300                 
Asn Ala Thr Gly Glu Val Ala
305                 310     


<210> 5712
<211> 359
<212> PRT
<213> Homo sapiens

<400> 5712
Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp
 1               5                  10                  15      
Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro
            20                  25                  30          
Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu
        35                  40                  45              
Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser
    50                  55                  60                  
Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr
65                  70                  75                  80  
Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe
                85                  90                  95      
Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu
            100                 105                 110         
Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu
        115                 120                 125             
Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val
    130                 135                 140                 
Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser
145                 150                 155                 160 
Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn
                165                 170                 175     
Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro
            180                 185                 190         
Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe
        195                 200                 205             
Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys
    210                 215                 220                 
Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys
225                 230                 235                 240 
Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His
                245                 250                 255     
Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg
            260                 265                 270         
Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile
        275                 280                 285             
Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe
    290                 295                 300                 
Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile
305                 310                 315                 320 
Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr
                325                 330                 335     
Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro
            340                 345                 350         
Ala Pro Cys Phe Glu Val Glu
        355                 


<210> 5713
<211> 359
<212> PRT
<213> Homo sapiens

<400> 5713
Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp
 1               5                  10                  15      
Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro
            20                  25                  30          
Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu
        35                  40                  45              
Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser
    50                  55                  60                  
Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr
65                  70                  75                  80  
Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe
                85                  90                  95      
Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu
            100                 105                 110         
Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu
        115                 120                 125             
Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val
    130                 135                 140                 
Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser
145                 150                 155                 160 
Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn
                165                 170                 175     
Ile Thr Val Cys Ala Phe His Tyr Glu Ser Arg Asn Ser Thr Leu Pro
            180                 185                 190         
Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Ser Cys Phe Pro Phe
        195                 200                 205             
Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys
    210                 215                 220                 
Ala Tyr Glu Ile Gln Lys Asn Asn Pro Arg Asn Asp Asp Ile Phe Arg
225                 230                 235                 240 
Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His
                245                 250                 255     
Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Gln Gly Ile Ile Arg
            260                 265                 270         
Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile
        275                 280                 285             
Trp Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe
    290                 295                 300                 
Leu Gly Lys Lys Phe Lys Lys Asp Ile Leu Gln Leu Leu Lys Tyr Ile
305                 310                 315                 320 
Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr
                325                 330                 335     
Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro
            340                 345                 350         
Ala Pro Cys Phe Glu Val Glu
        355                 


<210> 5714
<211> 271
<212> PRT
<213> Homo sapiens

<400> 5714
Met Ala Pro Arg Ala Leu Pro Gly Ser Ala Val Leu Ala Ala Ala Val
 1               5                  10                  15      
Phe Val Gly Gly Ala Val Ser Ser Pro Leu Val Ala Pro Asp Asn Gly
            20                  25                  30          
Ser Ser Arg Thr Leu His Ser Arg Thr Glu Thr Thr Pro Ser Pro Ser
        35                  40                  45              
Asn Asp Thr Gly Asn Gly His Pro Glu Tyr Ile Ala Tyr Ala Leu Val
    50                  55                  60                  
Pro Val Phe Phe Ile Met Gly Leu Phe Gly Val Leu Ile Cys His Leu
65                  70                  75                  80  
Leu Lys Lys Lys Gly Tyr Arg Cys Thr Thr Glu Ala Glu Gln Asp Ile
                85                  90                  95      
Glu Glu Glu Lys Val Glu Lys Ile Glu Leu Asn Asp Ser Val Asn Glu
            100                 105                 110         
Asn Ser Asp Thr Val Gly Gln Ile Val His Tyr Ile Met Lys Asn Glu
        115                 120                 125             
Ala Asn Ala Asp Val Leu Lys Ala Met Val Ala Asp Asn Ser Leu Tyr
    130                 135                 140                 
Asp Pro Glu Ser Pro Val Thr Pro Ser Thr Pro Gly Ser Pro Pro Val
145                 150                 155                 160 
Ser Pro Gly Pro Leu Ser Pro Gly Gly Thr Pro Gly Lys His Val Cys
                165                 170                 175     
Gly His His Leu His Thr Val Gly Gly Val Val Glu Arg Asp Val Cys
            180                 185                 190         
His Arg Cys Arg His Lys Arg Trp His Phe Ile Lys Pro Thr Asn Lys
        195                 200                 205             
Ser Arg Glu Ser Arg Pro Arg Arg Gln Gly Glu Val Thr Val Leu Ser
    210                 215                 220                 
Val Gly Arg Phe Arg Val Thr Lys Val Glu His Lys Ser Asn Gln Lys
225                 230                 235                 240 
Glu Arg Arg Ser Leu Met Ser Val Ser Gly Ala Glu Thr Val Asn Gly
                245                 250                 255     
Glu Val Pro Ala Thr Pro Val Lys Arg Glu Arg Ser Gly Thr Glu
            260                 265                 270     


<210> 5715
<211> 412
<212> PRT
<213> Homo sapiens

<400> 5715
Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala
 1               5                  10                  15      
Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile
            20                  25                  30          
Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala
        35                  40                  45              
Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu
    50                  55                  60                  
Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr
65                  70                  75                  80  
Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe
                85                  90                  95      
Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu
            100                 105                 110         
Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser
        115                 120                 125             
Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser
    130                 135                 140                 
Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys
145                 150                 155                 160 
Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg
                165                 170                 175     
Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala
            180                 185                 190         
Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val
        195                 200                 205             
Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val
    210                 215                 220                 
Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln
225                 230                 235                 240 
Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys
                245                 250                 255     
Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val
            260                 265                 270         
His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu
        275                 280                 285             
Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro
    290                 295                 300                 
Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu
305                 310                 315                 320 
Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro
                325                 330                 335     
Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu
            340                 345                 350         
Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser
        355                 360                 365             
Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile
    370                 375                 380                 
Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp
385                 390                 395                 400 
Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu
                405                 410         


<210> 5716
<211> 766
<212> PRT
<213> Homo sapiens

<400> 5716
Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala
 1               5                  10                  15      
Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr
            20                  25                  30          
Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr
        35                  40                  45              
Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser
    50                  55                  60                  
Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn
65                  70                  75                  80  
Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp
                85                  90                  95      
Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln
            100                 105                 110         
Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr
        115                 120                 125             
Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr
    130                 135                 140                 
Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val
145                 150                 155                 160 
Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile
                165                 170                 175     
Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp
            180                 185                 190         
Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe
        195                 200                 205             
Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala
    210                 215                 220                 
Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe
225                 230                 235                 240 
Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr
                245                 250                 255     
Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn
            260                 265                 270         
Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr
        275                 280                 285             
Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr
    290                 295                 300                 
Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln
305                 310                 315                 320 
Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg
                325                 330                 335     
Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly
            340                 345                 350         
Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly
        355                 360                 365             
Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile
    370                 375                 380                 
Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly
385                 390                 395                 400 
Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr
                405                 410                 415     
Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr
            420                 425                 430         
Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu
        435                 440                 445             
Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu
    450                 455                 460                 
Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr
465                 470                 475                 480 
Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp
                485                 490                 495     
Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys
            500                 505                 510         
Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met
        515                 520                 525             
Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu
    530                 535                 540                 
Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg
545                 550                 555                 560 
Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala
                565                 570                 575     
Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His
            580                 585                 590         
Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu
        595                 600                 605             
Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile
    610                 615                 620                 
Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu
625                 630                 635                 640 
Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val
                645                 650                 655     
Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly
            660                 665                 670         
Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val
        675                 680                 685             
Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His
    690                 695                 700                 
Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser
705                 710                 715                 720 
Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr
                725                 730                 735     
Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr
            740                 745                 750         
Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro
        755                 760                 765     


<210> 5717
<211> 529
<212> PRT
<213> Homo sapiens

<400> 5717
Met Ala Arg Phe Pro Lys Ala Asp Leu Ala Ala Ala Gly Val Met Leu
 1               5                  10                  15      
Leu Cys His Phe Phe Thr Asp Gln Phe Gln Phe Ala Asp Gly Lys Pro
            20                  25                  30          
Gly Asp Gln Ile Leu Asp Trp Gln Tyr Gly Val Thr Gln Ala Phe Pro
        35                  40                  45              
His Thr Glu Glu Glu Val Glu Val Asp Ser His Ala Tyr Ser His Arg
    50                  55                  60                  
Trp Lys Arg Asn Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala
65                  70                  75                  80  
Ser Val Gly Gln Asp Ser Pro Glu Pro Arg Ser Phe Thr Asp Leu Leu
                85                  90                  95      
Leu Asp Asp Gly Gln Asp Asn Asn Thr Gln Ile Glu Glu Asp Thr Asp
            100                 105                 110         
His Asn Tyr Tyr Ile Ser Arg Ile Tyr Gly Pro Ser Asp Ser Ala Ser
        115                 120                 125             
Arg Asp Leu Trp Val Asn Ile Asp Gln Met Glu Lys Asp Lys Val Lys
    130                 135                 140                 
Ile His Gly Ile Leu Ser Asn Thr His Arg Gln Ala Ala Arg Val Asn
145                 150                 155                 160 
Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Phe Leu Arg Glu Ile Thr
                165                 170                 175     
Val Ala Thr Gly Gly Phe Ile Tyr Thr Gly Glu Val Val His Arg Met
            180                 185                 190         
Leu Thr Ala Thr Gln Tyr Ile Ala Pro Leu Met Ala Asn Phe Asp Pro
        195                 200                 205             
Ser Val Ser Arg Asn Ser Thr Val Arg Tyr Phe Asp Asn Gly Thr Ala
    210                 215                 220                 
Leu Val Val Gln Trp Asp His Val His Leu Gln Asp Asn Tyr Asn Leu
225                 230                 235                 240 
Gly Ser Phe Thr Phe Gln Ala Thr Leu Leu Met Asp Gly Arg Ile Ile
                245                 250                 255     
Phe Gly Tyr Lys Glu Ile Pro Val Leu Val Thr Gln Ile Ser Ser Thr
            260                 265                 270         
Asn His Pro Val Lys Val Gly Leu Ser Asp Ala Phe Val Val Val His
        275                 280                 285             
Arg Ile Gln Gln Ile Pro Asn Val Arg Arg Arg Thr Ile Tyr Glu Tyr
    290                 295                 300                 
His Arg Val Glu Leu Gln Met Ser Lys Ile Thr Asn Ile Ser Ala Val
305                 310                 315                 320 
Glu Met Thr Pro Leu Pro Thr Cys Leu Gln Phe Asn Arg Cys Gly Pro
                325                 330                 335     
Cys Val Ser Ser Gln Ile Gly Phe Asn Cys Ser Trp Cys Ser Lys Leu
            340                 345                 350         
Gln Arg Cys Ser Ser Gly Phe Asp Arg His Arg Gln Asp Trp Val Asp
        355                 360                 365             
Ser Gly Cys Pro Glu Glu Ser Lys Glu Lys Met Cys Glu Asn Thr Glu
    370                 375                 380                 
Pro Val Glu Thr Ser Ser Arg Thr Thr Thr Thr Ile Gly Ala Thr Thr
385                 390                 395                 400 
Thr Gln Phe Arg Val Leu Thr Thr Thr Arg Arg Ala Val Thr Ser Gln
                405                 410                 415     
Phe Pro Thr Ser Leu Pro Thr Glu Asp Asp Thr Lys Ile Ala Leu His
            420                 425                 430         
Leu Lys Asp Asn Gly Ala Ser Thr Asp Asp Ser Ala Ala Glu Lys Lys
        435                 440                 445             
Gly Gly Thr Leu His Ala Gly Leu Ile Val Gly Ile Leu Ile Leu Val
    450                 455                 460                 
Leu Ile Val Ala Thr Ala Ile Leu Val Thr Val Tyr Met Tyr His His
465                 470                 475                 480 
Pro Thr Ser Ala Ala Ser Ile Phe Phe Ile Glu Arg Arg Pro Ser Arg
                485                 490                 495     
Trp Pro Ala Met Lys Phe Arg Arg Gly Ser Gly His Pro Ala Tyr Ala
            500                 505                 510         
Glu Val Glu Pro Val Gly Glu Lys Glu Gly Phe Ile Val Ser Glu Gln
        515                 520                 525             
Cys
    


<210> 5718
<211> 480
<212> PRT
<213> Homo sapiens

<400> 5718
Met Ala Arg Phe Pro Lys Ala Asp Leu Ala Ala Ala Gly Val Met Leu
 1               5                  10                  15      
Leu Cys His Phe Phe Thr Asp Gln Phe Gln Phe Ala Asp Gly Lys Pro
            20                  25                  30          
Gly Asp Gln Ile Leu Asp Trp Gln Tyr Gly Val Thr Gln Ala Phe Pro
        35                  40                  45              
His Thr Glu Glu Glu Val Glu Val Asp Ser His Ala Tyr Ser His Arg
    50                  55                  60                  
Trp Lys Arg Asn Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala
65                  70                  75                  80  
Ser Val Gly Gln Asp Ser Pro Glu Pro Arg Ser Phe Thr Asp Leu Leu
                85                  90                  95      
Leu Asp Asp Gly Gln Asp Asn Asn Thr Gln Ile Glu Arg Val Asn Leu
            100                 105                 110         
Ser Phe Asp Phe Pro Phe Tyr Gly His Phe Leu Arg Glu Ile Thr Val
        115                 120                 125             
Ala Thr Gly Gly Phe Ile Tyr Thr Gly Glu Val Val His Arg Met Leu
    130                 135                 140                 
Thr Ala Thr Gln Tyr Ile Ala Pro Leu Met Ala Asn Phe Asp Pro Ser
145                 150                 155                 160 
Val Ser Arg Asn Ser Thr Val Arg Tyr Phe Asp Asn Gly Thr Ala Leu
                165                 170                 175     
Val Val Gln Trp Asp His Val His Leu Gln Asp Asn Tyr Asn Leu Gly
            180                 185                 190         
Ser Phe Thr Phe Gln Ala Thr Leu Leu Met Asp Gly Arg Ile Ile Phe
        195                 200                 205             
Gly Tyr Lys Glu Ile Pro Val Leu Val Thr Gln Ile Ser Ser Thr Asn
    210                 215                 220                 
His Pro Val Lys Val Gly Leu Ser Asp Ala Phe Val Val Val His Arg
225                 230                 235                 240 
Ile Gln Gln Ile Pro Asn Val Arg Arg Arg Thr Ile Tyr Glu Tyr His
                245                 250                 255     
Arg Val Glu Leu Gln Met Ser Lys Ile Thr Asn Ile Ser Ala Val Glu
            260                 265                 270         
Met Thr Pro Leu Pro Thr Cys Leu Gln Phe Asn Arg Cys Gly Pro Cys
        275                 280                 285             
Val Ser Ser Gln Ile Gly Phe Asn Cys Ser Trp Cys Ser Lys Leu Gln
    290                 295                 300                 
Arg Cys Ser Ser Gly Phe Asp Arg His Arg Gln Asp Trp Val Asp Ser
305                 310                 315                 320 
Gly Cys Pro Glu Glu Ser Lys Glu Lys Met Cys Glu Asn Thr Glu Pro
                325                 330                 335     
Val Glu Thr Ser Ser Arg Thr Thr Thr Thr Val Gly Ala Thr Thr Thr
            340                 345                 350         
Gln Phe Arg Val Leu Thr Thr Thr Arg Arg Ala Val Thr Ser Gln Phe
        355                 360                 365             
Pro Thr Ser Leu Pro Thr Glu Asp Asp Thr Lys Ile Ala Leu His Leu
    370                 375                 380                 
Lys Asp Asn Gly Ala Ser Thr Asp Asp Ser Ala Ala Glu Lys Lys Gly
385                 390                 395                 400 
Gly Thr Leu His Ala Gly Leu Ile Ile Gly Ile Leu Ile Leu Val Leu
                405                 410                 415     
Ile Val Ala Thr Ala Ile Leu Val Thr Val Tyr Met Tyr His His Pro
            420                 425                 430         
Thr Ser Ala Ala Ser Ile Phe Phe Ile Glu Arg Arg Pro Ser Arg Trp
        435                 440                 445             
Pro Ala Met Lys Phe Arg Arg Gly Ser Gly His Pro Ala Tyr Ala Glu
    450                 455                 460                 
Val Glu Pro Val Gly Glu Lys Glu Gly Phe Ile Val Ser Glu Gln Cys
465                 470                 475                 480 


<210> 5719
<211> 428
<212> PRT
<213> Homo sapiens

<400> 5719
Met Gln Glu Leu His Leu Leu Trp Trp Ala Leu Leu Leu Gly Leu Ala
 1               5                  10                  15      
Gln Ala Cys Pro Glu Pro Cys Asp Cys Gly Glu Lys Tyr Gly Phe Gln
            20                  25                  30          
Ile Ala Asp Cys Ala Tyr Arg Asp Leu Glu Ser Val Pro Pro Gly Phe
        35                  40                  45              
Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Arg Leu Pro Gly
    50                  55                  60                  
Leu Pro Glu Gly Ala Phe Arg Glu Val Pro Leu Leu Gln Ser Leu Trp
65                  70                  75                  80  
Leu Ala His Asn Glu Ile Arg Thr Val Ala Ala Gly Ala Leu Ala Ser
                85                  90                  95      
Leu Ser His Leu Lys Ser Leu Asp Leu Ser His Asn Leu Ile Ser Asp
            100                 105                 110         
Phe Ala Trp Ser Asp Leu His Asn Leu Ser Ala Leu Gln Leu Leu Lys
        115                 120                 125             
Met Asp Ser Asn Glu Leu Thr Phe Ile Pro Arg Asp Ala Phe Arg Ser
    130                 135                 140                 
Leu Arg Ala Leu Arg Ser Leu Gln Leu Asn His Asn Arg Leu His Thr
145                 150                 155                 160 
Leu Ala Glu Gly Thr Phe Thr Pro Leu Thr Ala Leu Ser His Leu Gln
                165                 170                 175     
Ile Asn Glu Asn Pro Phe Asp Cys Thr Cys Gly Ile Val Trp Leu Lys
            180                 185                 190         
Thr Trp Ala Leu Thr Thr Ala Val Ser Ile Pro Glu Gln Asp Asn Ile
        195                 200                 205             
Ala Cys Thr Ser Pro His Val Leu Lys Gly Thr Pro Leu Ser Arg Leu
    210                 215                 220                 
Pro Pro Leu Pro Cys Ser Ala Pro Ser Val Gln Leu Ser Tyr Gln Pro
225                 230                 235                 240 
Ser Gln Asp Gly Ala Glu Leu Arg Pro Gly Phe Val Leu Ala Leu His
                245                 250                 255     
Cys Asp Val Asp Gly Gln Pro Ala Pro Gln Leu His Trp His Ile Gln
            260                 265                 270         
Ile Pro Ser Gly Ile Val Glu Ile Thr Ser Pro Asn Val Gly Thr Asp
        275                 280                 285             
Gly Arg Ala Leu Pro Gly Thr Pro Val Ala Ser Ser Gln Pro Arg Phe
    290                 295                 300                 
Gln Ala Phe Ala Asn Gly Ser Leu Leu Ile Pro Asp Phe Gly Lys Leu
305                 310                 315                 320 
Glu Glu Gly Thr Tyr Ser Cys Leu Ala Thr Asn Glu Leu Gly Ser Ala
                325                 330                 335     
Glu Ser Ser Val Asp Val Ala Leu Ala Thr Pro Gly Glu Gly Gly Glu
            340                 345                 350         
Asp Thr Leu Gly Arg Arg Phe His Gly Lys Ala Val Glu Gly Lys Gly
        355                 360                 365             
Cys Tyr Thr Val Asp Asn Glu Val Gln Pro Ser Gly Pro Glu Asp Asn
    370                 375                 380                 
Val Val Ile Ile Tyr Leu Ser Arg Ala Gly Asn Pro Glu Ala Ala Val
385                 390                 395                 400 
Ala Glu Gly Val Pro Gly Gln Leu Pro Pro Gly Leu Leu Leu Leu Gly
                405                 410                 415     
Gln Ser Leu Leu Leu Phe Phe Phe Leu Thr Ser Phe
            420                 425             


<210> 5720
<211> 577
<212> PRT
<213> Homo sapiens

<400> 5720
Met Cys Lys Glu Gln Lys Ala Thr Lys Lys Ser Lys Val Gly Phe Leu
 1               5                  10                  15      
Asp Pro Leu Ala Thr Asp Asn Gln Lys Glu Cys Glu Ala Trp Pro Asp
            20                  25                  30          
Leu Arg Thr Ser Glu Glu Asp Ser Lys Ser Cys Ser Gly Ala Leu Ser
        35                  40                  45              
Thr Ala Leu Glu Glu Leu Ala Lys Val Ser Glu Glu Leu Cys Ser Phe
    50                  55                  60                  
Gln Glu Glu Ile Arg Lys Arg Ser Asn His Arg Arg Met Lys Ser Asp
65                  70                  75                  80  
Ser Phe Leu Gln Glu Met Pro Asn Val Thr Asn Ile Pro His Gly Asp
                85                  90                  95      
Pro Met Ile Asn Asn Asp Gln Cys Ile Leu Pro Ile Ser Leu Glu Lys
            100                 105                 110         
Glu Lys Gln Lys Asn Arg Lys Asn Leu Ser Cys Thr Asn Val Leu Gln
        115                 120                 125             
Ser Asn Ser Thr Lys Lys Cys Gly Ile Asp Thr Ile Asp Leu Lys Arg
    130                 135                 140                 
Asn Glu Thr Pro Pro Val Pro Pro Pro Arg Ser Thr Ser Arg Asn Phe
145                 150                 155                 160 
Pro Ser Ser Asp Ser Glu Gln Ala Tyr Glu Arg Trp Lys Glu Arg Leu
                165                 170                 175     
Asp His Asn Ser Trp Val Pro His Glu Gly Arg Ser Lys Arg Asn Tyr
            180                 185                 190         
Asn Pro His Phe Pro Leu Arg Gln Gln Glu Met Ser Met Leu Tyr Pro
        195                 200                 205             
Asn Glu Gly Lys Thr Ser Lys Asp Gly Ile Ile Phe Ser Ser Leu Val
    210                 215                 220                 
Pro Glu Val Lys Ile Asp Ser Lys Pro Pro Ser Asn Glu Asp Val Gly
225                 230                 235                 240 
Leu Ser Met Trp Ser Cys Asp Ile Gly Ile Gly Ala Lys Arg Ser Pro
                245                 250                 255     
Ser Thr Ser Trp Phe Gln Lys Thr Cys Ser Thr Pro Ser Asn Pro Lys
            260                 265                 270         
Tyr Glu Met Val Ile Pro Asp His Pro Ala Lys Ser His Pro Asp Leu
        275                 280                 285             
His Val Ser Asn Asp Cys Ser Ser Ser Val Ala Glu Ser Ser Ser Pro
    290                 295                 300                 
Leu Arg Asn Phe Ser Cys Gly Phe Glu Arg Thr Thr Arg Asn Glu Lys
305                 310                 315                 320 
Leu Ala Ala Lys Thr Asp Glu Phe Asn Arg Thr Val Phe Arg Thr Asp
                325                 330                 335     
Arg Asn Cys Gln Ala Ile Gln Gln Asn His Ser Cys Ser Lys Ser Ser
            340                 345                 350         
Glu Asp Leu Lys Pro Cys Asp Thr Ser Ser Thr His Thr Gly Ser Ile
        355                 360                 365             
Ser Gln Ser Asn Asp Val Ser Gly Ile Trp Lys Thr Asn Ala His Met
    370                 375                 380                 
Pro Val Pro Met Glu Asn Val Pro Asp Asn Pro Thr Lys Lys Ser Thr
385                 390                 395                 400 
Thr Gly Leu Val Arg Gln Met Gln Gly His Leu Ser Pro Arg Ser Tyr
                405                 410                 415     
Arg Asn Met Leu His Glu His Asp Trp Arg Pro Ser Asn Leu Ser Gly
            420                 425                 430         
Arg Pro Arg Ser Ala Asp Pro Arg Ser Asn Tyr Gly Val Val Glu Lys
        435                 440                 445             
Leu Leu Lys Thr Tyr Glu Thr Ala Thr Glu Ser Ala Leu Gln Asn Ser
    450                 455                 460                 
Lys Cys Phe Gln Asp Asn Trp Thr Lys Cys Asn Ser Asp Val Ser Gly
465                 470                 475                 480 
Gly Ala Thr Leu Ser Gln His Leu Glu Met Leu Gln Met Glu Gln Gln
                485                 490                 495     
Phe Gln Gln Lys Thr Ala Val Trp Gly Gly Gln Glu Val Lys Gln Gly
            500                 505                 510         
Ile Asp Pro Lys Lys Ile Thr Glu Glu Ser Met Ser Val Asn Ala Ser
        515                 520                 525             
His Gly Lys Gly Phe Ser Arg Pro Ala Arg Pro Ala Asn Arg Arg Leu
    530                 535                 540                 
Pro Ser Arg Trp Ala Ser Arg Ser Pro Ser Ala Pro Pro Ala Leu Arg
545                 550                 555                 560 
Arg Thr Thr His Asn Tyr Thr Ile Ser Leu Arg Ser Glu Ala Leu Met
                565                 570                 575     
Val
    


<210> 5721
<211> 86
<212> PRT
<213> Homo sapiens

<400> 5721
Met Val Arg His Pro Tyr Ser Val Gln Thr Gln Leu Ser Thr Glu Ala
 1               5                  10                  15      
Lys Ala Ile Trp Arg Ser Met Gln Gln Gln Glu Thr Asn Leu Leu Ala
            20                  25                  30          
Asn Leu Thr Thr Asn Asp Ala Arg Asp Asn Ser Lys Asp Phe Gln Asn
        35                  40                  45              
Ser Lys Val Gly Ala Ala Ala Thr Ser Arg Asp Glu Gly Cys Asn Cys
    50                  55                  60                  
Pro Ile Ile Gly Glu Ile Val Ile Ser Cys Tyr Trp Leu Phe Glu Ile
65                  70                  75                  80  
Pro Pro Leu Ile Ser Glu
                85      


<210> 5722
<211> 109
<212> PRT
<213> Homo sapiens

<400> 5722
Asp Ile Leu Leu Thr Gln Thr Pro Leu Ser Leu Ser Ile Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Cys Asp Gly Tyr Thr Tyr Ser Tyr Trp
        35                  40                  45              
Phe Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Phe Val
    50                  55                  60                  
Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Asn Gly Ser Gly Ser
65                  70                  75                  80  
Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Glu Asp Val Gly
                85                  90                  95      
Val Tyr Tyr Cys Met Gln Ala Leu Gln Leu Pro Pro Thr
            100                 105                 


<210> 5723
<211> 118
<212> PRT
<213> Homo sapiens

<400> 5723
Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Ser Gly Asp Ile Val Ile Ala Gln Thr Pro Leu Ser Trp Pro
            20                  25                  30          
Val Thr Ser Gly Glu Thr His Ile Ser Cys Arg Ser Ser Gln Ser Leu
        35                  40                  45              
Leu Ser Ser Asp Gly Tyr Thr Tyr Ser Tyr Trp Phe Leu Gln Lys Pro
    50                  55                  60                  
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Phe Val Ser Asn Arg Ala Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Asn Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95      
Leu Lys Ile Ser Arg Val Ala Glu Asp Val Gly Val Tyr Tyr Cys Met
            100                 105                 110         
Gln Ala Leu Gln Leu Pro
        115             


<210> 5724
<211> 986
<212> PRT
<213> Homo sapiens

<400> 5724
Cys Lys Lys Lys Ile Asp Val Met Pro Ile Gln Ile Leu Ala Asn Glu
 1               5                  10                  15      
Glu Met Lys Val Met Cys Asp Asn Asn Pro Val Ser Leu Asn Cys Cys
            20                  25                  30          
Ser Gln Gly Asn Val Asn Trp Ser Lys Val Glu Trp Lys Gln Glu Gly
        35                  40                  45              
Lys Ile Asn Ile Pro Gly Thr Pro Glu Thr Asp Ile Asp Ser Ser Cys
    50                  55                  60                  
Ser Arg Tyr Thr Leu Lys Ala Asp Gly Thr Gln Cys Pro Ser Gly Ser
65                  70                  75                  80  
Ser Gly Thr Thr Val Ile Tyr Thr Cys Glu Phe Ile Ser Ala Tyr Gly
                85                  90                  95      
Ala Arg Gly Ser Ala Asn Ile Lys Val Thr Phe Ile Ser Val Ala Asn
            100                 105                 110         
Leu Thr Ile Thr Pro Asp Pro Ile Ser Val Ser Glu Gly Gln Asn Phe
        115                 120                 125             
Ser Ile Lys Cys Ile Ser Asp Val Ser Asn Tyr Asp Glu Val Tyr Trp
    130                 135                 140                 
Asn Thr Ser Ala Gly Ile Lys Ile Tyr Gln Arg Phe Tyr Thr Thr Arg
145                 150                 155                 160 
Arg Tyr Leu Asp Gly Ala Glu Ser Val Leu Thr Val Lys Thr Ser Thr
                165                 170                 175     
Arg Glu Trp Asn Gly Thr Tyr His Cys Ile Phe Arg Tyr Lys Asn Ser
            180                 185                 190         
Tyr Ser Ile Ala Thr Lys Asp Val Ile Val His Pro Leu Pro Leu Lys
        195                 200                 205             
Leu Asn Ile Met Val Asp Pro Leu Glu Ala Thr Val Ser Cys Ser Gly
    210                 215                 220                 
Ser His His Ile Lys Cys Cys Ile Glu Glu Asp Gly Asp Tyr Lys Val
225                 230                 235                 240 
Thr Phe His Met Gly Ser Ser Ser Leu Pro Ala Ala Lys Glu Val Asn
                245                 250                 255     
Lys Lys Gln Val Cys Tyr Lys His Asn Phe Asn Ala Ser Ser Val Ser
            260                 265                 270         
Trp Cys Ser Lys Thr Val Asp Val Cys Cys His Phe Thr Asn Ala Ala
        275                 280                 285             
Asn Asn Ser Val Trp Ser Pro Ser Met Lys Leu Asn Leu Val Pro Gly
    290                 295                 300                 
Glu Asn Ile Thr Cys Gln Asp Pro Val Ile Gly Val Gly Glu Pro Gly
305                 310                 315                 320 
Lys Val Ile Gln Lys Leu Cys Arg Phe Ser Asn Val Pro Ser Ser Pro
                325                 330                 335     
Glu Ser Pro Ile Gly Gly Thr Ile Thr Tyr Lys Cys Val Gly Ser Gln
            340                 345                 350         
Trp Glu Glu Lys Arg Asn Asp Cys Ile Ser Ala Pro Ile Asn Ser Leu
        355                 360                 365             
Leu Gln Met Ala Lys Ala Leu Ile Lys Ser Pro Ser Gln Asp Glu Met
    370                 375                 380                 
Leu Pro Thr Tyr Leu Lys Asp Leu Ser Ile Ser Ile Asp Lys Ala Glu
385                 390                 395                 400 
His Glu Ile Ser Ser Ser Pro Gly Ser Leu Gly Ala Ile Ile Asn Ile
                405                 410                 415     
Leu Asp Leu Leu Ser Thr Val Pro Thr Gln Val Asn Ser Glu Met Met
            420                 425                 430         
Thr His Val Leu Ser Thr Val Asn Val Ile Leu Gly Lys Pro Val Leu
        435                 440                 445             
Asn Thr Trp Lys Val Leu Gln Gln Gln Trp Thr Asn Gln Ser Ser Gln
    450                 455                 460                 
Leu Leu His Ser Val Glu Arg Phe Ser Gln Ala Leu Gln Ser Gly Asp
465                 470                 475                 480 
Ser Pro Pro Leu Ser Phe Ser Gln Thr Asn Val Gln Met Ser Ser Thr
                485                 490                 495     
Val Ile Lys Ser Ser His Pro Glu Thr Tyr Gln Gln Arg Phe Val Phe
            500                 505                 510         
Pro Tyr Phe Asp Leu Trp Gly Asn Val Val Ile Asp Lys Ser Tyr Leu
        515                 520                 525             
Glu Asn Leu Gln Ser Asp Ser Ser Ile Val Thr Met Ala Phe Pro Thr
    530                 535                 540                 
Leu Gln Ala Ile Leu Ala Gln Asp Ile Gln Glu Asn Asn Phe Ala Glu
545                 550                 555                 560 
Ser Leu Val Met Thr Thr Thr Val Ser His Asn Thr Thr Met Pro Phe
                565                 570                 575     
Arg Ile Ser Met Thr Phe Lys Asn Asn Ser Pro Ser Gly Gly Glu Thr
            580                 585                 590         
Lys Cys Val Phe Trp Asn Phe Arg Leu Ala Asn Asn Thr Gly Gly Trp
        595                 600                 605             
Asp Ser Ser Gly Cys Tyr Val Glu Glu Gly Asp Gly Asp Asn Val Thr
    610                 615                 620                 
Cys Ile Cys Asp His Leu Thr Ser Phe Ser Ile Leu Met Ser Pro Asp
625                 630                 635                 640 
Ser Pro Asp Pro Ser Ser Leu Leu Gly Ile Leu Leu Asp Ile Ile Ser
                645                 650                 655     
Tyr Val Gly Val Gly Phe Ser Ile Leu Ser Leu Ala Ala Cys Leu Val
            660                 665                 670         
Val Glu Ala Val Val Trp Lys Ser Val Thr Lys Asn Arg Thr Ser Tyr
        675                 680                 685             
Met Arg His Thr Cys Ile Val Asn Ile Ala Ala Ser Leu Leu Val Ala
    690                 695                 700                 
Asn Thr Trp Phe Ile Val Val Ala Ala Ile Gln Asp Asn Arg Tyr Ile
705                 710                 715                 720 
Leu Cys Lys Thr Ala Cys Val Ala Ala Thr Phe Phe Ile His Phe Phe
                725                 730                 735     
Tyr Leu Ser Val Phe Phe Trp Met Leu Thr Leu Gly Leu Met Leu Phe
            740                 745                 750         
Tyr Arg Leu Val Phe Ile Leu His Glu Thr Ser Arg Ser Thr Gln Lys
        755                 760                 765             
Ala Ile Ala Phe Cys Leu Gly Tyr Gly Cys Pro Leu Ala Ile Ser Val
    770                 775                 780                 
Ile Thr Leu Gly Ala Thr Gln Pro Arg Glu Val Tyr Thr Arg Lys Asn
785                 790                 795                 800 
Val Cys Trp Leu Asn Trp Glu Asp Thr Lys Ala Leu Leu Ala Phe Ala
                805                 810                 815     
Ile Pro Ala Leu Ile Ile Val Val Val Asn Ile Thr Ile Thr Ile Val
            820                 825                 830         
Val Ile Thr Lys Ile Leu Arg Pro Ser Ile Gly Asp Lys Pro Cys Lys
        835                 840                 845             
Gln Glu Lys Ser Ser Leu Phe Gln Ile Ser Lys Ser Ile Gly Val Leu
    850                 855                 860                 
Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Leu Thr Thr Val Phe
865                 870                 875                 880 
Pro Gly Thr Asn Leu Val Phe His Ile Ile Phe Ala Ile Leu Asn Val
                885                 890                 895     
Phe Gln Gly Leu Phe Ile Leu Leu Phe Gly Cys Leu Trp Asp Leu Lys
            900                 905                 910         
Val Gln Glu Ala Leu Leu Asn Lys Phe Ser Leu Ser Arg Trp Ser Ser
        915                 920                 925             
Gln His Ser Lys Ser Thr Ser Leu Gly Ser Ser Thr Pro Val Phe Ser
    930                 935                 940                 
Met Ser Ser Pro Ile Ser Arg Arg Phe Asn Asn Leu Phe Gly Lys Thr
945                 950                 955                 960 
Gly Thr Tyr Asn Val Ser Thr Pro Glu Ala Thr Ser Ser Ser Leu Glu
                965                 970                 975     
Asn Ser Ser Ser Ala Ser Ser Leu Leu Asn
            980                 985     


<210> 5725
<211> 1301
<212> PRT
<213> Homo sapiens

<400> 5725
Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile
 1               5                  10                  15      
Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His
            20                  25                  30          
Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg
        35                  40                  45              
Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr
    50                  55                  60                  
Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile
65                  70                  75                  80  
Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr
                85                  90                  95      
Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg
            100                 105                 110         
Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp
        115                 120                 125             
Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val
    130                 135                 140                 
Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn
145                 150                 155                 160 
Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val
                165                 170                 175     
Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala
            180                 185                 190         
Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly
        195                 200                 205             
Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys
    210                 215                 220                 
Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser
225                 230                 235                 240 
Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn
                245                 250                 255     
Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn
            260                 265                 270         
Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr
        275                 280                 285             
Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp
    290                 295                 300                 
Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser
305                 310                 315                 320 
Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr
                325                 330                 335     
Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu
            340                 345                 350         
Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met
        355                 360                 365             
Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn
    370                 375                 380                 
Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser
385                 390                 395                 400 
Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro
                405                 410                 415     
Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp
            420                 425                 430         
Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr
        435                 440                 445             
Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys
    450                 455                 460                 
Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile
465                 470                 475                 480 
Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val
                485                 490                 495     
Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile
            500                 505                 510         
Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser
        515                 520                 525             
Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His
    530                 535                 540                 
Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val
545                 550                 555                 560 
Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu
                565                 570                 575     
Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile
            580                 585                 590         
Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Thr Gly Ser Ser Ser
        595                 600                 605             
Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His
    610                 615                 620                 
Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val
625                 630                 635                 640 
Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser
                645                 650                 655     
Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro
            660                 665                 670         
Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg
        675                 680                 685             
Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile
    690                 695                 700                 
Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys
705                 710                 715                 720 
Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile
                725                 730                 735     
Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu
            740                 745                 750         
Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly
        755                 760                 765             
Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro
    770                 775                 780                 
Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn
785                 790                 795                 800 
Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln
                805                 810                 815     
Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe
            820                 825                 830         
Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln
        835                 840                 845             
Thr Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu
    850                 855                 860                 
Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn
865                 870                 875                 880 
Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser
                885                 890                 895     
Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp
            900                 905                 910         
Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val
        915                 920                 925             
Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn
    930                 935                 940                 
Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg
945                 950                 955                 960 
Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu
                965                 970                 975     
Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser
            980                 985                 990         
Phe Ser Ile Leu Met Ser Pro Asp Ser Pro Asp Pro Ser Ser Leu Leu
        995                 1000                1005            
Gly Ile Leu Leu Asp Ile Ile Ser Tyr Val Gly Val Gly Phe Ser Ile
    1010                1015                1020                
Leu Ser Leu Ala Ala Cys Leu Val Val Glu Ala Val Val Trp Lys Ser
1025                1030                1035                1040
Val Thr Lys Asn Arg Thr Ser Tyr Met Arg His Thr Cys Ile Val Asn
                1045                1050                1055    
Ile Ala Ala Ser Leu Leu Val Ala Asn Thr Trp Phe Ile Val Val Ala
            1060                1065                1070        
Ala Ile Gln Asp Asn Arg Tyr Ile Leu Cys Lys Thr Ala Cys Val Ala
        1075                1080                1085            
Ala Thr Phe Phe Ile His Phe Phe Tyr Leu Ser Val Phe Phe Trp Met
    1090                1095                1100                
Leu Thr Leu Gly Leu Met Leu Phe Tyr Arg Leu Val Phe Ile Leu His
1105                1110                1115                1120
Glu Thr Ser Arg Ser Thr Gln Lys Ala Ile Ala Phe Cys Leu Gly Tyr
                1125                1130                1135    
Gly Cys Pro Leu Ala Ile Ser Val Ile Thr Leu Gly Ala Thr Gln Pro
            1140                1145                1150        
Arg Glu Val Tyr Thr Arg Lys Asn Val Cys Trp Leu Asn Trp Glu Asp
        1155                1160                1165            
Thr Lys Ala Leu Leu Ala Phe Ala Ile Pro Ala Leu Ile Ile Val Val
    1170                1175                1180                
Val Asn Ile Thr Ile Thr Ile Val Val Ile Thr Lys Ile Leu Arg Pro
1185                1190                1195                1200
Ser Ile Gly Asp Lys Pro Cys Lys Gln Glu Lys Ser Ser Leu Phe Gln
                1205                1210                1215    
Ile Ser Lys Ser Ile Gly Val Leu Thr Pro Leu Leu Gly Leu Thr Trp
            1220                1225                1230        
Gly Phe Gly Leu Thr Thr Val Phe Pro Gly Thr Asn Leu Val Phe His
        1235                1240                1245            
Ile Ile Phe Ala Ile Leu Asn Val Phe Gln Gly Leu Phe Ile Leu Leu
    1250                1255                1260                
Phe Gly Cys Leu Trp Asp Leu Lys Ser Thr Ser Leu Gly Ser Ser Thr
1265                1270                1275                1280
Pro Val Phe Ser Met Ser Ser Pro Ile Ser Arg Arg Phe Asn Asn Leu
                1285                1290                1295    
Phe Gly Lys Thr Gly
            1300    


<210> 5726
<211> 429
<212> PRT
<213> Homo sapiens

<400> 5726
Met Ala Thr Glu Gln Arg Pro Phe His Leu Val Val Phe Gly Ala Ser
 1               5                  10                  15      
Gly Phe Thr Gly Gln Phe Val Thr Glu Glu Val Ala Arg Glu Gln Val
            20                  25                  30          
Asp Pro Glu Arg Ser Ser Arg Leu Pro Trp Ala Val Ala Gly Arg Ser
        35                  40                  45              
Arg Glu Lys Leu Gln Arg Val Leu Glu Lys Ala Ala Leu Lys Leu Gly
    50                  55                  60                  
Arg Pro Thr Leu Ser Ser Glu Val Gly Ile Ile Ile Cys Asp Ile Ala
65                  70                  75                  80  
Asn Pro Ala Ser Leu Asp Glu Met Ala Lys Gln Ala Thr Val Val Leu
                85                  90                  95      
Asn Cys Val Gly Pro Tyr Arg Phe Tyr Gly Glu Pro Val Ile Lys Ala
            100                 105                 110         
Cys Ile Glu Asn Gly Ala Ser Cys Ile Asp Ile Ser Gly Glu Pro Gln
        115                 120                 125             
Phe Leu Glu Leu Met Gln Leu Lys Tyr His Glu Lys Ala Ala Asp Lys
    130                 135                 140                 
Gly Val Tyr Ile Ile Gly Ser Ser Gly Phe Asp Ser Ile Pro Ala Asp
145                 150                 155                 160 
Leu Gly Val Ile Tyr Thr Arg Asn Lys Met Asn Gly Thr Leu Thr Ala
                165                 170                 175     
Val Glu Ser Phe Leu Thr Ile His Ser Gly Pro Glu Gly Leu Ser Ile
            180                 185                 190         
His Asp Gly Thr Trp Lys Ser Ala Ile Tyr Gly Phe Gly Asp Gln Ser
        195                 200                 205             
Asn Leu Arg Lys Leu Arg Asn Val Ser Asn Leu Lys Pro Val Pro Leu
    210                 215                 220                 
Ile Gly Pro Lys Leu Lys Arg Arg Trp Pro Ile Ser Tyr Cys Arg Glu
225                 230                 235                 240 
Leu Lys Gly Tyr Ser Ile Pro Phe Met Gly Ser Asp Val Ser Val Val
                245                 250                 255     
Arg Arg Thr Gln Arg Tyr Leu Tyr Glu Asn Leu Glu Glu Ser Pro Val
            260                 265                 270         
Gln Tyr Ala Ala Tyr Val Thr Val Gly Gly Ile Thr Ser Val Ile Lys
        275                 280                 285             
Leu Met Phe Ala Gly Leu Phe Phe Leu Phe Phe Val Arg Phe Gly Ile
    290                 295                 300                 
Gly Arg Gln Leu Leu Ile Lys Phe Pro Trp Phe Phe Ser Phe Gly Tyr
305                 310                 315                 320 
Phe Ser Lys Gln Gly Pro Thr Gln Lys Gln Ile Asp Ala Ala Ser Phe
                325                 330                 335     
Thr Leu Thr Phe Phe Gly Gln Gly Tyr Ser Gln Gly Thr Gly Thr Asp
            340                 345                 350         
Lys Asn Lys Pro Asn Ile Lys Ile Cys Thr Gln Val Lys Gly Pro Glu
        355                 360                 365             
Ala Gly Tyr Val Ala Thr Pro Ile Ala Met Val Gln Ala Ala Met Thr
    370                 375                 380                 
Leu Leu Ser Asp Ala Ser His Leu Pro Lys Ala Gly Gly Val Phe Thr
385                 390                 395                 400 
Pro Gly Ala Ala Phe Ser Lys Thr Lys Leu Ile Asp Arg Leu Asn Lys
                405                 410                 415     
His Gly Ile Glu Phe Ser Val Ile Ser Ser Ser Glu Val
            420                 425                 


<210> 5727
<211> 973
<212> PRT
<213> Homo sapiens

<400> 5727
Met Gly Glu Ser Leu Gly His His Gly Tyr His Gly Asn Gly Thr Asp
 1               5                  10                  15      
Gly Glu Ser Ser Glu Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Gly
            20                  25                  30          
Glu Ser Leu Glu Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Arg Glu
        35                  40                  45              
Ser Leu Glu Arg Arg Gly Asp His Gly Asn Gly Thr Asp Gly Glu Ser
    50                  55                  60                  
Ser Glu Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Leu
65                  70                  75                  80  
Glu Arg Arg Gly Tyr His Gly Ser Asp Thr Asp Arg Glu Ser Leu Glu
                85                  90                  95      
Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser Glu His
            100                 105                 110         
Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Leu Gly Arg Pro
        115                 120                 125             
Gly Tyr His Arg Asn Gly Thr Asp Gly Glu Asn Ser Glu Arg Arg Gly
    130                 135                 140                 
Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser Glu Arg Arg Gly Tyr
145                 150                 155                 160 
His Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg Arg Gly Tyr His
                165                 170                 175     
Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg Arg Gly Tyr His Gly
            180                 185                 190         
Asn Gly Thr Asp Gly Glu Ser Ser Gly Cys Arg Gly Tyr His Gly Asn
        195                 200                 205             
Gly Thr Asp Gly Glu Ser Ser Glu Met Ala Pro Thr Gly Arg Val Gln
    210                 215                 220                 
Asn Thr Ser Leu Glu His Arg Gly Tyr His Gly Ser Gly Thr Asp Gly
225                 230                 235                 240 
Glu Ser Ser Gly Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu
                245                 250                 255     
Ser Ser Gly Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser
            260                 265                 270         
Ser Gly Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser
        275                 280                 285             
Gly Arg Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly
    290                 295                 300                 
Arg Pro Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg
305                 310                 315                 320 
Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg Arg
                325                 330                 335     
Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg Arg Gly
            340                 345                 350         
Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg Arg Gly Tyr
        355                 360                 365             
His Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg Arg Gly Tyr His
    370                 375                 380                 
Gly Asn Gly Thr Asp Gly Glu Ser Ser Gly Arg Arg Gly Tyr His Gly
385                 390                 395                 400 
Asn Gly Thr Asp Gly Glu Ser Ser Glu Met Ala Pro Thr Gly Arg Val
                405                 410                 415     
Gln Asn Thr Ser Leu Glu His Arg Gly Tyr His Gly Ser Gly Thr Asp
            420                 425                 430         
Gly Glu Ser Leu Glu Cys Arg Gly Tyr His Gly Asn Gly Thr Asp Arg
        435                 440                 445             
Glu Ser Leu Glu Arg Arg Ala Tyr His Gly Asn Gly Thr Asp Gly Glu
    450                 455                 460                 
Ser Leu Glu His His Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser
465                 470                 475                 480 
Leu Glu Arg His Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Leu
                485                 490                 495     
Gly His Cys Gly Tyr His Gly Asn Gly Thr Asp Ser Glu Ser Leu Glu
            500                 505                 510         
Cys Cys Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Leu Gly Arg
        515                 520                 525             
Arg Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Leu Glu Cys His
    530                 535                 540                 
Gly Tyr His Gly Asn Gly Thr Asp Gly Glu Ser Leu Glu Arg Arg Gly
545                 550                 555                 560 
Tyr Tyr Gly Asn Gly Thr Asp Gly Glu Ser Leu Glu Arg Arg Gly Tyr
                565                 570                 575     
His Gly Asn Val Thr Asp Gly Glu Ser Leu Glu Arg His Gly Tyr His
            580                 585                 590         
Gly Asn Gly Thr Asp Gly Glu Ser Leu Glu Arg Arg Gly Tyr His Gly
        595                 600                 605             
Asn Gly Thr Asp Arg Glu Ser Leu Glu Arg Arg Gly Tyr His Gly Asn
    610                 615                 620                 
Gly Thr His Ser Glu Ser Leu Glu His His Gly Tyr His Gly Asn Gly
625                 630                 635                 640 
Thr Asp Arg Glu Ser Leu Glu Arg His Gly Tyr His Gly Asn Gly Thr
                645                 650                 655     
Asp Arg Glu Ser Leu Glu Arg Arg Gly Tyr His Gly Asn Gly Thr Asn
            660                 665                 670         
Arg Glu Ser Leu Glu His Arg Gly Tyr His Gly Asn Gly Thr His Ser
        675                 680                 685             
Glu Ser Leu Glu His Arg Gly Tyr His Gly Asn Gly Thr His Ser Glu
    690                 695                 700                 
Ser Leu Glu His His Gly Tyr His Gly Asn Gly Thr Asp Arg Glu Ser
705                 710                 715                 720 
Leu Glu Arg Arg Gly Tyr His Gly Asn Gly Thr Asn Arg Glu Ser Leu
                725                 730                 735     
Glu His Arg Gly Tyr His Gly Asn Gly Thr His Ser Glu Ser Leu Glu
            740                 745                 750         
His Arg Gly Tyr His Gly Asn Gly Thr Asp Ser Glu Ser Leu Glu His
        755                 760                 765             
Arg Gly Tyr His Gly Asn Gly Thr Asp Ser Glu Ser Leu Glu His Arg
    770                 775                 780                 
Gly Tyr His Gly Asn Gly Thr Asn Arg Glu Ser Leu Glu His Cys Gly
785                 790                 795                 800 
Tyr His Gly Asn Gly Thr His Ser Glu Ser Leu Glu His Arg Gly Tyr
                805                 810                 815     
His Gly Asn Gly Thr Asp Ser Glu Ser Leu Glu His Arg Gly Tyr His
            820                 825                 830         
Gly Asn Gly Thr Asp Ser Glu Ser Leu Glu Arg Cys Gly Tyr His Gly
        835                 840                 845             
Asn Gly Thr His Ser Glu Ser Leu Glu His Arg Gly Tyr His Gly Asn
    850                 855                 860                 
Gly Thr Asp Gly Glu Ser Leu Glu Arg Arg Gly Tyr His Gly Asn Gly
865                 870                 875                 880 
Thr Asn Gly Glu Ser Leu Glu His His Gly Tyr Arg Gly Asn Gly Thr
                885                 890                 895     
Asp Gly Glu Ser Leu Glu His Arg Gly Tyr His Gly Asn Gly Thr His
            900                 905                 910         
Ser Glu Ser Leu Glu His His Gly Tyr His Gly Asn Gly Thr Asp Arg
        915                 920                 925             
Glu Thr Gln Gly Leu Cys Pro Ser Ser Leu Leu Val Asp Gln Ser Ser
    930                 935                 940                 
Gln Gly Lys Arg Pro Ile Pro Ala Leu Pro Pro Ala Ser Phe Ala Pro
945                 950                 955                 960 
Leu Asn Leu Trp Glu Ile Glu Gly Ile Ile Phe Gly Pro
                965                 970             


<210> 5728
<211> 1234
<212> PRT
<213> Homo sapiens

<400> 5728
Gly Asn Thr Gln Leu Pro Pro Arg Asn Pro Val Lys Ala Asn Ala Met
 1               5                  10                  15      
Phe Gly Ala Gly Asp Glu Asp Asp Thr Asp Phe Leu Ser Pro Ser Gly
            20                  25                  30          
Gly Ala Arg Leu Ala Ser Leu Phe Gly Leu Asp Gln Ala Ala Ala Gly
        35                  40                  45              
His Gly Asn Glu Phe Phe Gln Tyr Thr Ala Pro Lys Gln Pro Lys Lys
    50                  55                  60                  
Gly Gln Gly Thr Ala Ala Thr Gly Asn Gln Ala Thr Pro Lys Thr Ala
65                  70                  75                  80  
Pro Ala Thr Met Ser Thr Pro Thr Ile Leu Val Ala Thr Ala Val His
                85                  90                  95      
Ala Tyr Arg Tyr Thr Asn Gly Gln Tyr Val Lys Gln Gly Lys Phe Gly
            100                 105                 110         
Ala Ala Val Leu Gly Asn His Thr Ala Arg Glu Tyr Arg Ile Leu Leu
        115                 120                 125             
Tyr Ile Ser Gln Gln Gln Pro Val Thr Val Ala Arg Ile His Val Asn
    130                 135                 140                 
Phe Glu Leu Met Val Arg Pro Asn Asn Tyr Ser Thr Phe Tyr Asp Asp
145                 150                 155                 160 
Gln Arg Gln Asn Trp Ser Ile Met Phe Glu Ser Glu Lys Ala Ala Val
                165                 170                 175     
Glu Phe Asn Lys Gln Val Cys Ile Ala Lys Cys Asn Ser Thr Ser Ser
            180                 185                 190         
Leu Asp Ala Val Leu Ser Gln Asp Leu Ile Val Ala Asp Gly Pro Ala
        195                 200                 205             
Val Glu Val Gly Asp Ser Leu Glu Val Ala Tyr Thr Gly Trp Leu Phe
    210                 215                 220                 
Gln Asn His Val Leu Gly Gln Val Phe Asp Ser Thr Ala Asn Lys Asp
225                 230                 235                 240 
Lys Leu Leu Arg Leu Lys Leu Gly Ser Gly Lys Val Ile Lys Gly Trp
                245                 250                 255     
Glu Asp Gly Met Leu Gly Met Lys Lys Gly Gly Lys Arg Leu Leu Ile
            260                 265                 270         
Val Pro Pro Ala Cys Ala Val Gly Ser Glu Gly Val Ile Gly Trp Thr
        275                 280                 285             
Gln Ala Thr Asp Ser Ile Leu Val Phe Glu Val Glu Val Arg Arg Val
    290                 295                 300                 
Lys Phe Ala Arg Asp Ser Gly Ser Asp Gly His Ser Val Ser Ser Arg
305                 310                 315                 320 
Asp Ser Ala Ala Pro Ser Pro Ile Pro Gly Ala Asp Asn Leu Ser Ala
                325                 330                 335     
Asp Pro Val Val Ser Pro Pro Thr Ser Ile Pro Phe Lys Ser Gly Glu
            340                 345                 350         
Pro Ala Leu Arg Thr Lys Ser Asn Ser Leu Ser Glu Gln Leu Ala Ile
        355                 360                 365             
Asn Thr Ser Pro Asp Ala Val Lys Ala Lys Leu Ile Ser Arg Met Ala
    370                 375                 380                 
Lys Met Gly Gln Pro Met Leu Pro Ile Leu Pro Pro Gln Leu Asp Ser
385                 390                 395                 400 
Asn Asp Ser Glu Ile Glu Asp Val Asn Thr Leu Gln Gly Gly Gly Gln
                405                 410                 415     
Pro Val Val Thr Pro Ser Val Gln Pro Ser Leu Gln Pro Ala His Pro
            420                 425                 430         
Ala Leu Pro Gln Met Thr Ser Gln Ala Pro Gln Pro Ser Val Thr Gly
        435                 440                 445             
Leu Gln Ala Pro Ser Ala Ala Leu Met Gln Val Ser Ser Leu Asp Ser
    450                 455                 460                 
His Ser Ala Val Ser Gly Asn Ala Gln Ser Phe Gln Pro Tyr Ala Gly
465                 470                 475                 480 
Met Gln Ala Tyr Ala Tyr Pro Gln Ala Ser Ala Val Thr Ser Gln Leu
                485                 490                 495     
Gln Pro Val Arg Pro Leu Tyr Pro Ala Pro Leu Ser Gln Pro Pro His
            500                 505                 510         
Phe Gln Gly Ser Gly Asp Met Ala Ser Phe Leu Met Thr Glu Ala Arg
        515                 520                 525             
Gln His Asn Thr Glu Ile Arg Met Ala Val Ser Lys Val Ala Asp Lys
    530                 535                 540                 
Met Asp His Leu Met Thr Lys Val Glu Glu Leu Gln Lys His Ser Ala
545                 550                 555                 560 
Gly Asn Ser Met Leu Ile Pro Ser Met Ser Val Thr Met Glu Thr Ser
                565                 570                 575     
Met Ile Met Ser Asn Ile Gln Arg Ile Ile Gln Glu Asn Glu Arg Leu
            580                 585                 590         
Lys Gln Glu Ile Leu Glu Lys Ser Asn Arg Ile Glu Glu Gln Asn Asp
        595                 600                 605             
Lys Ile Ser Glu Leu Ile Glu Arg Asn Gln Arg Tyr Val Glu Gln Ser
    610                 615                 620                 
Asn Leu Met Met Glu Lys Arg Asn Asn Ser Leu Gln Thr Ala Thr Glu
625                 630                 635                 640 
Asn Thr Gln Ala Arg Val Leu His Ala Glu Gln Glu Lys Ala Lys Val
                645                 650                 655     
Thr Glu Glu Leu Ala Ala Ala Thr Ala Gln Val Ser His Leu Gln Leu
            660                 665                 670         
Lys Met Thr Ala His Gln Lys Lys Glu Thr Glu Leu Gln Met Gln Leu
        675                 680                 685             
Thr Glu Ser Leu Lys Glu Thr Asp Leu Leu Arg Gly Gln Leu Thr Lys
    690                 695                 700                 
Val Gln Ala Lys Leu Ser Glu Leu Gln Glu Thr Ser Glu Gln Ala Gln
705                 710                 715                 720 
Ser Lys Phe Lys Ser Glu Lys Gln Asn Arg Lys Gln Leu Glu Leu Lys
                725                 730                 735     
Val Thr Ser Leu Glu Glu Glu Leu Thr Asp Leu Arg Val Glu Lys Glu
            740                 745                 750         
Ser Leu Glu Lys Asn Leu Ser Glu Arg Lys Lys Lys Ser Ala Gln Glu
        755                 760                 765             
Arg Ser Gln Ala Glu Glu Glu Ile Asp Glu Ile Arg Lys Ser Tyr Gln
    770                 775                 780                 
Glu Glu Leu Asp Lys Leu Arg Gln Leu Leu Lys Lys Thr Arg Val Ser
785                 790                 795                 800 
Thr Asp Gln Ala Ala Ala Glu Gln Leu Ser Leu Val Gln Ala Glu Leu
                805                 810                 815     
Gln Thr Gln Trp Glu Ala Lys Cys Glu His Leu Leu Ala Ser Ala Lys
            820                 825                 830         
Asp Glu His Leu Gln Gln Tyr Gln Glu Val Cys Ala Gln Arg Asp Ala
        835                 840                 845             
Tyr Gln Gln Lys Leu Val Gln Leu Gln Glu Lys Cys Leu Ala Leu Gln
    850                 855                 860                 
Ala Gln Ile Thr Ala Leu Thr Lys Gln Asn Glu Gln His Ile Lys Glu
865                 870                 875                 880 
Leu Glu Lys Asn Lys Ser Gln Met Ser Gly Val Glu Ala Ala Ala Ser
                885                 890                 895     
Asp Pro Ser Glu Lys Val Lys Lys Ile Met Asn Gln Val Phe Gln Ser
            900                 905                 910         
Leu Arg Arg Glu Phe Glu Leu Glu Glu Ser Tyr Asn Gly Arg Thr Ile
        915                 920                 925             
Leu Gly Thr Ile Met Asn Thr Ile Lys Met Val Thr Leu Gln Leu Leu
    930                 935                 940                 
Asn Gln Gln Glu Gln Glu Lys Glu Glu Ser Ser Ser Glu Glu Glu Glu
945                 950                 955                 960 
Glu Lys Ala Glu Glu Arg Pro Arg Arg Pro Ser Gln Glu Gln Ser Ala
                965                 970                 975     
Ser Ala Ser Ser Gly Gln Pro Gln Ala Pro Leu Asn Arg Glu Arg Pro
            980                 985                 990         
Glu Ser Pro Met Val Pro Ser Glu Gln Val Val Glu Glu Ala Val Pro
        995                 1000                1005            
Leu Pro Pro Gln Ala Leu Thr Thr Ser Gln Asp Gly His Arg Arg Lys
    1010                1015                1020                
Gly Asp Ser Glu Ala Glu Ala Leu Ser Glu Ile Lys Asp Gly Ser Leu
1025                1030                1035                1040
Pro Pro Glu Leu Ser Cys Ile Pro Ser His Arg Val Leu Gly Pro Pro
                1045                1050                1055    
Thr Ser Ile Pro Pro Glu Pro Leu Gly Pro Val Ser Met Asp Ser Glu
            1060                1065                1070        
Cys Glu Glu Ser Leu Ala Ala Ser Pro Met Ala Ala Lys Pro Asp Asn
        1075                1080                1085            
Pro Ser Gly Lys Val Cys Val Arg Glu Val Ala Pro Asp Gly Pro Leu
    1090                1095                1100                
Gln Glu Ser Ser Thr Arg Leu Ser Leu Thr Ser Asp Pro Glu Glu Gly
1105                1110                1115                1120
Asp Pro Leu Ala Leu Gly Pro Glu Ser Pro Gly Glu Pro Gln Pro Pro
                1125                1130                1135    
Gln Leu Lys Lys Asp Asp Val Thr Ser Ser Thr Gly Pro His Lys Glu
            1140                1145                1150        
Leu Ser Ser Thr Glu Ala Gly Ser Thr Val Ala Gly Ala Ala Leu Arg
        1155                1160                1165            
Pro Ser His His Ser Gln Arg Ser Ser Leu Ser Gly Asp Glu Glu Asp
    1170                1175                1180                
Glu Leu Phe Lys Gly Ala Thr Leu Lys Ala Leu Arg Pro Lys Ala Gln
1185                1190                1195                1200
Pro Glu Glu Glu Asp Glu Asp Glu Val Ser Met Lys Gly Arg Pro Pro
                1205                1210                1215    
Pro Thr Pro Leu Phe Gly Asp Asp Asp Asp Asp Asp Asp Ile Asp Trp
            1220                1225                1230        
Leu Gly
        


<210> 5729
<211> 923
<212> PRT
<213> Homo sapiens

<400> 5729
Met Asp Ser Ile Gly Ser Ser Gly Leu Arg Gln Gly Glu Glu Thr Leu
 1               5                  10                  15      
Ser Cys Ser Glu Glu Gly Leu Pro Gly Pro Ser Asp Ser Ser Glu Leu
            20                  25                  30          
Val Gln Glu Cys Leu Gln Gln Phe Lys Val Thr Arg Ala Gln Leu Gln
        35                  40                  45              
Gln Ile Gln Ala Ser Leu Leu Gly Ser Met Glu Gln Ala Leu Arg Gly
    50                  55                  60                  
Gln Ala Ser Pro Ala Pro Ala Val Arg Met Leu Pro Thr Tyr Val Gly
65                  70                  75                  80  
Ser Thr Pro His Gly Thr Glu Gln Gly Asp Phe Val Val Leu Glu Leu
                85                  90                  95      
Gly Ala Thr Gly Ala Ser Leu Arg Val Leu Trp Val Thr Leu Thr Gly
            100                 105                 110         
Ile Glu Gly His Arg Val Glu Pro Arg Ser Gln Glu Phe Val Ile Pro
        115                 120                 125             
Gln Glu Val Met Leu Gly Ala Gly Gln Gln Leu Phe Asp Phe Ala Ala
    130                 135                 140                 
His Cys Leu Ser Glu Phe Leu Asp Ala Gln Pro Val Asn Lys Gln Gly
145                 150                 155                 160 
Leu Gln Leu Gly Phe Ser Phe Ser Phe Pro Cys His Gln Thr Gly Leu
                165                 170                 175     
Asp Arg Ser Thr Leu Ile Ser Trp Thr Lys Gly Phe Arg Cys Ser Gly
            180                 185                 190         
Val Glu Gly Gln Asp Val Val Gln Leu Leu Arg Asp Ala Ile Arg Arg
        195                 200                 205             
Gln Gly Ala Tyr Asn Ile Asp Val Val Ala Val Val Asn Asp Thr Val
    210                 215                 220                 
Gly Thr Met Met Gly Cys Glu Pro Gly Val Arg Pro Cys Glu Val Gly
225                 230                 235                 240 
Leu Val Val Asp Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu Ala Arg
                245                 250                 255     
His Val Ala Val Leu Asp Glu Asp Arg Gly Arg Val Cys Val Ser Val
            260                 265                 270         
Glu Trp Gly Ser Leu Ser Asp Asp Gly Ala Leu Gly Pro Val Leu Thr
        275                 280                 285             
Thr Phe Asp His Thr Leu Asp His Glu Ser Leu Asn Pro Gly Ala Gln
    290                 295                 300                 
Arg Phe Glu Lys Met Ile Gly Gly Leu Tyr Leu Gly Glu Leu Val Arg
305                 310                 315                 320 
Leu Val Leu Ala His Leu Ala Arg Cys Gly Val Leu Phe Gly Gly Cys
                325                 330                 335     
Thr Ser Pro Ala Leu Leu Ser Gln Gly Ser Ile Leu Leu Glu His Val
            340                 345                 350         
Ala Glu Met Glu Asp Pro Ser Thr Gly Ala Ala Arg Val His Ala Ile
        355                 360                 365             
Leu Gln Asp Leu Gly Leu Ser Pro Gly Ala Ser Asp Val Glu Leu Val
    370                 375                 380                 
Gln His Val Cys Ala Ala Val Cys Thr Arg Ala Ala Gln Leu Cys Ala
385                 390                 395                 400 
Ala Ala Leu Ala Ala Val Leu Ser Cys Leu Gln His Ser Arg Glu Gln
                405                 410                 415     
Gln Thr Leu Gln Val Ala Val Ala Thr Gly Gly Arg Val Cys Glu Arg
            420                 425                 430         
His Pro Arg Phe Cys Ser Val Leu Gln Gly Thr Val Met Leu Leu Ala
        435                 440                 445             
Pro Glu Cys Asp Val Ser Leu Ile Pro Ser Val Asp Gly Gly Gly Arg
    450                 455                 460                 
Gly Val Ala Met Val Thr Ala Val Ala Ala Arg Leu Ala Ala His Arg
465                 470                 475                 480 
Arg Leu Leu Glu Glu Thr Leu Ala Pro Phe Arg Leu Asn His Asp Gln
                485                 490                 495     
Leu Ala Ala Val Gln Ala Gln Met Arg Lys Ala Met Ala Lys Gly Leu
            500                 505                 510         
Arg Gly Glu Ala Ser Ser Leu Arg Met Leu Pro Thr Phe Val Arg Ala
        515                 520                 525             
Thr Pro Asp Gly Ser Glu Arg Gly Asp Phe Leu Ala Leu Asp Leu Gly
    530                 535                 540                 
Gly Thr Asn Phe Arg Val Leu Leu Val Arg Val Thr Thr Gly Val Gln
545                 550                 555                 560 
Ile Thr Ser Glu Ile Tyr Ser Ile Pro Glu Thr Val Ala Gln Gly Ser
                565                 570                 575     
Gly Gln Gln Leu Phe Asp His Ile Val Asp Cys Ile Val Asp Phe Gln
            580                 585                 590         
Gln Lys Gln Gly Leu Ser Gly Gln Ser Leu Pro Leu Gly Phe Thr Phe
        595                 600                 605             
Ser Phe Pro Cys Arg Gln Leu Gly Leu Asp Gln Gly Ile Leu Leu Asn
    610                 615                 620                 
Trp Thr Lys Gly Phe Lys Ala Ser Asp Cys Glu Gly Gln Asp Val Val
625                 630                 635                 640 
Ser Leu Leu Arg Glu Ala Ile Thr Arg Arg Gln Ala Val Glu Leu Asn
                645                 650                 655     
Val Val Ala Ile Val Asn Asp Thr Val Gly Thr Met Met Ser Cys Gly
            660                 665                 670         
Tyr Glu Asp Pro Arg Cys Glu Ile Gly Leu Ile Val Gly Thr Gly Thr
        675                 680                 685             
Asn Ala Cys Tyr Met Glu Glu Leu Arg Asn Val Ala Gly Val Pro Gly
    690                 695                 700                 
Asp Ser Gly Arg Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp
705                 710                 715                 720 
Asp Gly Ser Leu Ala Met Leu Ser Thr Arg Phe Asp Ala Ser Val Asp
                725                 730                 735     
Gln Ala Ser Ile Asn Pro Gly Lys Gln Arg Phe Glu Lys Met Ile Ser
            740                 745                 750         
Gly Met Tyr Leu Gly Glu Ile Val Arg His Ile Leu Leu His Leu Thr
        755                 760                 765             
Ser Leu Gly Val Leu Phe Arg Gly Gln Gln Ile Gln Arg Leu Gln Thr
    770                 775                 780                 
Arg Asp Ile Phe Lys Thr Lys Phe Leu Ser Glu Ile Glu Ser Asp Ser
785                 790                 795                 800 
Leu Ala Leu Arg Gln Val Arg Ala Ile Leu Glu Asp Leu Gly Leu Pro
                805                 810                 815     
Leu Thr Ser Asp Asp Ala Leu Met Val Leu Glu Val Cys Gln Ala Val
            820                 825                 830         
Ser Gln Arg Ala Ala Gln Leu Cys Gly Ala Gly Val Ala Ala Val Val
        835                 840                 845             
Glu Lys Ile Arg Gly Asn Arg Gly Leu Glu Glu Leu Ala Val Ser Val
    850                 855                 860                 
Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro Arg Phe Ser Ser Leu
865                 870                 875                 880 
Val Ala Ala Thr Val Arg Glu Leu Ala Pro Arg Cys Val Val Thr Phe
                885                 890                 895     
Leu Gln Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Val Thr Ala
            900                 905                 910         
Val Ala Cys Arg Leu Ala Gln Leu Thr Arg Val
        915                 920             


<210> 5730
<211> 657
<212> PRT
<213> Homo sapiens

<400> 5730
Met Ala Ala Arg Glu Thr Val Lys Ala Ala Ala Ala Pro Glu Ala Ala
 1               5                  10                  15      
Gln Arg Pro Glu Pro Gly Gly Thr Gly Arg Ala Asp Trp Leu Gly Gly
            20                  25                  30          
Arg Arg Gly Asp Ala Ala Ala His Arg Arg Leu Leu Arg Pro Pro Gly
        35                  40                  45              
Arg Gly Gly Val Pro Gly Gly Pro Val Arg Arg Glu Arg Gly Gly Arg
    50                  55                  60                  
Trp Leu Gly Ala Leu Arg Trp Arg Asp Arg Gly Gly Cys Ala Ala Ala
65                  70                  75                  80  
Val Gly Ala Asp His Leu Asp Val Val Arg Ser Leu Leu Arg Arg Gly
                85                  90                  95      
Ala Ser Val Asn Arg Thr Thr Arg Thr Asn Ser Thr Pro Leu Arg Ala
            100                 105                 110         
Ala Cys Phe Glu Gly Leu Leu Glu Val Val Pro Tyr Leu Val Gly Glu
        115                 120                 125             
His Gln Ala Asn Leu Glu Val Ala Asn Arg His Gly His Thr Cys Leu
    130                 135                 140                 
Met Ile Ser Cys Tyr Lys Gly His Arg Glu Ile Ala Arg Tyr Leu Leu
145                 150                 155                 160 
Glu Gln Gly Ala Gln Val Asn Trp Arg Ser Ala Lys Gly Asn Thr Ala
                165                 170                 175     
Leu His Asn Cys Ala Glu Thr Ser Ser Leu Glu Ile Leu Gln Leu Leu
            180                 185                 190         
Leu Gly Cys Lys Ala Ser Arg Glu Arg Asp Ser Tyr Gly Met Thr Pro
        195                 200                 205             
Leu Leu Pro Ala Arg Val Thr Gly His Thr Asn Ile Val Glu Tyr Leu
    210                 215                 220                 
Ile Gln Glu Gln Pro Gly Gln Glu Gln Val Thr Gly Val Glu Ala Gln
225                 230                 235                 240 
Pro Gly Leu Pro Gln Glu Gly Ser Ser Thr Ser Gln Gly Cys Arg Gln
                245                 250                 255     
Pro Gln Gly Ala Pro Cys Cys Ile Phe Ser Pro Glu Val Leu Asn Arg
            260                 265                 270         
Glu Ser Tyr Gln Ser Cys Cys Pro Thr Ser Arg Glu Ala Ala Val Glu
        275                 280                 285             
Ala Leu Glu Leu Leu Gly Ser Thr Tyr Val Asp Lys Lys Arg Asp Leu
    290                 295                 300                 
Leu Gly Ala Leu Lys His Trp Arg Arg Ala Met Glu Leu Arg His Gln
305                 310                 315                 320 
Arg Val Glu Tyr Leu Pro Lys Leu Glu Pro Pro Gln Leu Val Leu Ala
                325                 330                 335     
Tyr Asp Tyr Ser Arg Glu Val Asn Thr Thr Glu Glu Leu Glu Ala Leu
            340                 345                 350         
Ile Thr Asp Pro Asp Glu Met Arg Met Gln Ala Leu Leu Ile Arg Glu
        355                 360                 365             
Arg Ile Leu Ser Pro Ser His Pro Asp Ser Ser Tyr Cys Ile Arg Tyr
    370                 375                 380                 
Arg Gly Ala Val Tyr Ala Asp Ser Gly Asn Ile Glu Cys Tyr Ile Arg
385                 390                 395                 400 
Leu Trp Lys Tyr Ala Leu Asp Met Gln Gln Ser Asn Leu Glu Pro Leu
                405                 410                 415     
Ser Pro Met Thr Ala Ser Ser Phe Leu Ser Phe Ala Glu Leu Phe Ser
            420                 425                 430         
Tyr Val Leu Gln Asp Pro Ala Ala Lys Gly Ser Leu Gly Thr Gln Ile
        435                 440                 445             
Gly Phe Ala Asp Phe Met Gly Val Leu Thr Lys Gly Val Trp Glu Val
    450                 455                 460                 
Glu Trp Ala Leu Gln Leu Leu Arg Glu Pro Arg Asp Ser Ala Gln Phe
465                 470                 475                 480 
Asn Lys Ala Leu Ala Ile Ile Leu His Leu Leu Tyr Leu Leu Glu Lys
                485                 490                 495     
Val Glu Cys Thr Pro Ser Arg Glu His Leu Lys His Gln Thr Ile Tyr
            500                 505                 510         
Arg Leu Leu Lys Cys Ala Pro Arg Gly Lys Asn Gly Phe Thr Pro Leu
        515                 520                 525             
His Met Ala Val Asp Lys Asp Thr Thr Asn Val Gly Arg Tyr Ser Val
    530                 535                 540                 
Gly Arg Phe Pro Ser Leu His Val Val Lys Val Leu Phe Asp Cys Gly
545                 550                 555                 560 
Ala Asp Arg Asp Ser Arg Asp Phe Asp Asn Thr Pro Leu His Ile Ala
                565                 570                 575     
Ala Gln Asn Asn Cys Pro Ala Ile Val Asn Ala Leu Ile Glu Ala Gly
            580                 585                 590         
Ala His Met Asp Ala Thr Asn Ala Phe Lys Lys Thr Ala Tyr Glu Leu
        595                 600                 605             
Leu Glu Glu Lys Leu Leu Ala Arg Gly Thr Met Gln Pro Phe Asn Tyr
    610                 615                 620                 
Val Thr Leu Gln Cys Leu Ala Ala Gln Ala Leu Asp Lys Asn Lys Ile
625                 630                 635                 640 
Pro Tyr Lys Gly Phe Ile Pro Glu Asp Leu Lys Ala Phe Ile Glu Leu
                645                 650                 655     
His
    


<210> 5731
<211> 669
<212> PRT
<213> Homo sapiens

<400> 5731
Met Asp Leu Arg Thr Ala Val Tyr Asn Ala Ala Arg Asp Gly Lys Leu
 1               5                  10                  15      
Gln Leu Leu Gln Lys Leu Leu Ser Gly Arg Ser Arg Glu Glu Leu Asp
            20                  25                  30          
Glu Leu Thr Gly Glu Val Ala Gly Gly Gly Thr Pro Leu Leu Ile Ala
        35                  40                  45              
Ala Arg Tyr Gly His Leu Asp Val Val Glu Tyr Leu Val Asp Arg Cys
    50                  55                  60                  
Gly Ala Ser Val Glu Ala Gly Gly Ser Val His Phe Asp Gly Glu Thr
65                  70                  75                  80  
Ile Glu Gly Ala Pro Pro Leu Trp Ala Ala Ser Ala Ala Gly His Leu
                85                  90                  95      
Asp Val Val Arg Ser Leu Leu Arg Arg Gly Ala Ser Val Asn Arg Thr
            100                 105                 110         
Thr Arg Thr Asn Ser Thr Pro Leu Arg Ala Ala Cys Phe Asp Gly His
        115                 120                 125             
Leu Glu Val Val Arg Tyr Leu Val Gly Glu His Gln Ala Asp Leu Glu
    130                 135                 140                 
Val Ala Asn Arg His Gly His Thr Cys Leu Met Ile Ser Cys Tyr Lys
145                 150                 155                 160 
Gly His Arg Glu Ile Ala Arg Tyr Leu Leu Glu Gln Gly Ala Gln Val
                165                 170                 175     
Asn Arg Arg Ser Ala Lys Gly Asn Thr Ala Leu His Asp Cys Ala Glu
            180                 185                 190         
Ser Gly Ser Leu Glu Ile Leu Gln Leu Leu Leu Gly Cys Lys Ala Arg
        195                 200                 205             
Met Glu Arg Asp Gly Tyr Gly Met Thr Pro Leu Leu Ala Ala Ser Val
    210                 215                 220                 
Thr Gly His Thr Asn Ile Val Glu Tyr Leu Ile Gln Glu Gln Pro Gly
225                 230                 235                 240 
Gln Glu Gln Val Ala Gly Gly Glu Ala Gln Pro Gly Leu Pro Gln Glu
                245                 250                 255     
Asp Pro Ser Thr Ser Gln Gly Cys Ala Gln Pro Gln Gly Ala Pro Cys
            260                 265                 270         
Cys Ser Ser Ser Pro Glu Glu Pro Leu Asn Gly Glu Ser Tyr Glu Ser
        275                 280                 285             
Cys Cys Pro Thr Ser Arg Glu Ala Ala Val Glu Ala Leu Glu Leu Leu
    290                 295                 300                 
Gly Ala Thr Tyr Val Asp Lys Lys Arg Asp Leu Leu Gly Ala Leu Lys
305                 310                 315                 320 
His Trp Arg Arg Ala Met Glu Leu Arg His Gln Gly Gly Glu Tyr Leu
                325                 330                 335     
Pro Lys Pro Glu Pro Pro Gln Leu Val Leu Ala Tyr Asp Tyr Ser Arg
            340                 345                 350         
Glu Val Asn Thr Thr Glu Glu Leu Glu Ala Leu Ile Thr Asp Pro Asp
        355                 360                 365             
Glu Met Arg Met Gln Ala Leu Leu Ile Arg Glu Arg Ile Leu Gly Pro
    370                 375                 380                 
Ser His Pro Asp Thr Ser Tyr Tyr Ile Arg Tyr Arg Gly Ala Val Tyr
385                 390                 395                 400 
Ala Asp Ser Gly Asn Phe Glu Arg Cys Ile Arg Leu Trp Lys Tyr Ala
                405                 410                 415     
Leu Asp Met Gln Gln Ser Asn Leu Glu Pro Leu Ser Pro Met Thr Ala
            420                 425                 430         
Ser Ser Phe Leu Ser Phe Ala Glu Leu Phe Ser Tyr Val Leu Gln Asp
        435                 440                 445             
Arg Ala Ala Lys Gly Ser Leu Gly Thr Gln Ile Gly Phe Ala Asp Leu
    450                 455                 460                 
Met Gly Val Leu Thr Lys Gly Val Arg Glu Val Glu Arg Ala Leu Gln
465                 470                 475                 480 
Leu Pro Arg Glu Pro Gly Asp Ser Ala Gln Phe Thr Lys Ala Leu Ala
                485                 490                 495     
Ile Ile Leu His Leu Leu Tyr Leu Leu Glu Lys Val Glu Cys Thr Pro
            500                 505                 510         
Ser Gln Glu His Leu Lys His Gln Thr Val Tyr Arg Leu Leu Lys Cys
        515                 520                 525             
Ala Pro Arg Gly Lys Asn Gly Phe Thr Pro Leu His Met Ala Val Asp
    530                 535                 540                 
Lys Asp Thr Thr Asn Val Gly Arg Tyr Pro Val Gly Arg Phe Pro Ser
545                 550                 555                 560 
Leu His Val Val Lys Val Leu Leu Asp Cys Gly Ala Asp Pro Asp Ser
                565                 570                 575     
Arg Asp Phe Asp Asn Asn Thr Pro Leu His Ile Ala Ala Gln Asn Asn
            580                 585                 590         
Cys Pro Ala Ile Met Asn Ala Leu Ile Glu Ala Gly Ala His Met Asp
        595                 600                 605             
Ala Thr Asn Ala Phe Lys Lys Thr Ala Tyr Glu Leu Leu Asp Glu Lys
    610                 615                 620                 
Leu Leu Ala Arg Gly Thr Met Gln Pro Phe Asn Tyr Val Thr Leu Gln
625                 630                 635                 640 
Cys Leu Ala Ala Arg Ala Leu Asp Lys Asn Lys Ile Pro Tyr Lys Gly
                645                 650                 655     
Phe Ile Pro Glu Asp Leu Glu Ala Phe Ile Glu Leu His
            660                 665                 


<210> 5732
<211> 572
<212> PRT
<213> Homo sapiens

<400> 5732
Gly Gly Thr Pro Leu Leu Ile Ala Ala Cys Tyr Gly His Leu Asp Val
 1               5                  10                  15      
Val Glu Tyr Leu Val Asp Arg Cys Gly Ala Ser Val Glu Ala Gly Gly
            20                  25                  30          
Ser Val His Phe Asp Gly Glu Thr Val Glu Gly Ala Pro Pro Leu Trp
        35                  40                  45              
Ala Arg His Leu Asp Val Val Arg Ser Leu Leu Arg Arg Gly Ala Ser
    50                  55                  60                  
Val Asn Arg Thr Thr Arg Thr Asn Ser Thr Pro Leu Arg Ala Ala Cys
65                  70                  75                  80  
Phe Glu Gly Leu Leu Glu Val Val Pro Tyr Leu Val Gly Glu His Gln
                85                  90                  95      
Ala Asn Leu Glu Val Ala Asn Arg His Gly His Thr Cys Leu Met Ile
            100                 105                 110         
Ser Cys Tyr Lys Gly His Arg Glu Ile Ala Arg Tyr Leu Leu Glu Gln
        115                 120                 125             
Gly Ala Gln Val Asn Trp Arg Ser Ala Lys Gly Asn Thr Ala Leu His
    130                 135                 140                 
Asn Cys Ala Glu Thr Ser Ser Leu Glu Ile Leu Gln Leu Leu Leu Gly
145                 150                 155                 160 
Cys Lys Ala Ser Asn Val Asp Ser Tyr Gly Met Thr Pro Leu Leu Pro
                165                 170                 175     
Ala Arg Val Thr Gly His Thr Asn Ile Val Glu Glu Ser Tyr Gln Ser
            180                 185                 190         
Cys Cys Pro Thr Ser Arg Glu Ala Ala Val Glu Ala Leu Glu Leu Leu
        195                 200                 205             
Gly Ser Thr Tyr Val Asp Lys Lys Arg Asp Leu Leu Gly Ala Leu Lys
    210                 215                 220                 
His Trp Arg Arg Ala Met Glu Leu Arg His Gln Arg Val Glu Tyr Leu
225                 230                 235                 240 
Pro Lys Leu Glu Pro Pro Gln Leu Val Leu Ala Tyr Asp Tyr Ser Arg
                245                 250                 255     
Glu Val Asn Thr Thr Glu Glu Leu Glu Ala Leu Ile Thr Asp Pro Asp
            260                 265                 270         
Glu Met Arg Met Gln Ala Leu Leu Ile Arg Glu Arg Ile Leu Ser Pro
        275                 280                 285             
Ser His Pro Asp Ser Ser Tyr Cys Ile Arg Tyr Arg Gly Ala Val Tyr
    290                 295                 300                 
Ala Asp Ser Gly Asn Ile Glu Cys Tyr Ile Arg Leu Trp Lys Tyr Ala
305                 310                 315                 320 
Leu Asp Met Gln Gln Ser Asn Leu Glu Pro Leu Ser Pro Met Thr Ala
                325                 330                 335     
Ser Ser Phe Leu Ser Phe Ala Glu Leu Phe Ser Tyr Val Leu Gln Asp
            340                 345                 350         
Pro Ala Ala Lys Gly Ser Leu Gly Thr Gln Ile Gly Phe Ala Asp Phe
        355                 360                 365             
Met Gly Val Leu Thr Lys Gly Val Trp Glu Val Glu Trp Ala Leu Gln
    370                 375                 380                 
Leu Leu Arg Glu Pro Arg Asp Ser Ala Gln Phe Asn Lys Ala Leu Ala
385                 390                 395                 400 
Ile Ile Leu His Leu Leu Tyr Leu Leu Glu Lys Val Glu Cys Thr Pro
                405                 410                 415     
Ser Arg Glu His Leu Lys His Gln Thr Ile Tyr Arg Leu Leu Lys Cys
            420                 425                 430         
Ala Pro Arg Gly Lys Asn Gly Phe Thr Pro Leu His Met Ala Val Asp
        435                 440                 445             
Lys Asp Thr Thr Asn Val Gly Arg Tyr Ser Val Gly Arg Phe Pro Ser
    450                 455                 460                 
Leu His Val Val Lys Val Leu Phe Asp Cys Gly Ala Asp Arg Asp Ser
465                 470                 475                 480 
Arg Asp Phe Asp Asn Thr Pro Leu His Ile Ala Ala Gln Asn Asn Cys
                485                 490                 495     
Pro Ala Ile Val Asn Ala Leu Ile Glu Ala Gly Ala His Met Asp Ala
            500                 505                 510         
Thr Asn Ala Phe Lys Lys Thr Ala Tyr Glu Leu Leu Glu Glu Lys Leu
        515                 520                 525             
Leu Ala Arg Gly Thr Met Gln Pro Phe Asn Tyr Val Thr Leu Gln Cys
    530                 535                 540                 
Leu Ala Ala Gln Ala Leu Asp Lys Asn Lys Ile Pro Tyr Lys Gly Phe
545                 550                 555                 560 
Ile Pro Glu Asp Leu Lys Ala Phe Ile Glu Leu His
                565                 570         


<210> 5733
<211> 992
<212> PRT
<213> Homo sapiens

<400> 5733
Met Arg Lys Leu Phe Ser Phe Gly Arg Arg Leu Gly Gln Ala Leu Leu
 1               5                  10                  15      
Ser Ser Met Asp Gln Glu Tyr Ala Gly Pro Gly Tyr Asp Ile Arg Asp
            20                  25                  30          
Trp Glu Leu Arg Lys Ile His Arg Ala Ala Ile Lys Gly Asp Ala Ala
        35                  40                  45              
Glu Val Glu Arg Cys Leu Thr Arg Arg Phe Arg Asp Leu Asp Ala Arg
    50                  55                  60                  
Asp Arg Lys Asp Arg Thr Val Leu His Leu Ala Cys Ala His Gly Arg
65                  70                  75                  80  
Val Gln Val Val Thr Leu Leu Leu His Arg Arg Cys Gln Ile Asp Ile
                85                  90                  95      
Cys Asp Arg Leu Asn Arg Thr Pro Leu Met Lys Ala Val His Ser Gln
            100                 105                 110         
Glu Glu Ala Cys Ala Ile Val Leu Leu Glu Cys Gly Ala Asn Pro Asn
        115                 120                 125             
Ile Lys Asp Ile Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Asn
    130                 135                 140                 
Lys Gly Thr Ser Leu Ala Glu Arg Leu Leu Ser His His Ala Asn Ile
145                 150                 155                 160 
Glu Ala Leu Asn Lys Glu Gly Asn Thr Pro Leu Leu Phe Ala Ile Asn
                165                 170                 175     
Ser Arg Arg Gln His Met Val Glu Phe Leu Leu Lys Asn Gln Ala Asn
            180                 185                 190         
Ile His Ala Val Asp Asn Phe Lys Arg Thr Ala Leu Ile Leu Ala Val
        195                 200                 205             
Gln His Asn Leu Ser Ser Ile Val Thr Leu Leu Leu Gln Gln Asn Ile
    210                 215                 220                 
Arg Ile Ser Ser Gln Asp Met Phe Gly Gln Thr Ala Glu Asp Tyr Ala
225                 230                 235                 240 
Leu Cys Ser Asp Leu Arg Ser Ile Arg Gln Gln Ile Leu Glu His Lys
                245                 250                 255     
Asn Lys Met Leu Lys Asn His Leu Arg Asn Asp Asn Gln Glu Thr Ala
            260                 265                 270         
Ala Met Lys Pro Ala Asn Leu Lys Lys Arg Lys Glu Arg Ala Lys Ala
        275                 280                 285             
Glu His Asn Leu Lys Val Ala Ser Glu Glu Lys Gln Glu Arg Leu Gln
    290                 295                 300                 
Arg Ser Glu Asn Lys Gln Pro Gln Asp Ser Gln Ser Tyr Gly Lys Lys
305                 310                 315                 320 
Lys Asp Ala Met Tyr Gly Asn Phe Met Leu Lys Lys Asp Ile Ala Met
                325                 330                 335     
Leu Lys Glu Glu Leu Tyr Ala Ile Lys Asn Asp Ser Leu Arg Lys Glu
            340                 345                 350         
Lys Lys Tyr Ile Gln Glu Ile Lys Ser Ile Thr Glu Ile Asn Ala Asn
        355                 360                 365             
Phe Glu Lys Ser Val Arg Leu Asn Glu Lys Met Ile Thr Lys Thr Val
    370                 375                 380                 
Ala Arg Tyr Ser Gln Gln Leu Asn Asp Leu Lys Ala Glu Asn Ala Arg
385                 390                 395                 400 
Leu Asn Ser Glu Leu Glu Lys Glu Lys His Asn Lys Glu Arg Leu Glu
                405                 410                 415     
Ala Glu Val Glu Ser Leu His Ser Ser Leu Ala Thr Ala Ile Asn Glu
            420                 425                 430         
Tyr Asn Glu Ile Val Glu Arg Lys Asp Leu Glu Leu Val Leu Trp Arg
        435                 440                 445             
Ala Asp Asp Val Ser Arg His Glu Lys Met Gly Ser Asn Ile Ser Gln
    450                 455                 460                 
Leu Thr Asp Lys Asn Glu Leu Leu Thr Glu Gln Val His Lys Ala Arg
465                 470                 475                 480 
Val Lys Phe Asn Thr Leu Lys Gly Lys Leu Arg Glu Thr Arg Asp Ala
                485                 490                 495     
Leu Arg Glu Lys Thr Leu Ala Leu Gly Ser Val Gln Leu Asp Leu Arg
            500                 505                 510         
Gln Ala Gln His Arg Ile Lys Glu Met Lys Gln Met His Pro Asn Gly
        515                 520                 525             
Glu Ala Lys Glu Ser Gln Ser Ile Gly Lys Gln Asn Ser Leu Glu Glu
    530                 535                 540                 
Arg Ile Arg Gln Gln Glu Leu Glu Asn Leu Leu Leu Glu Arg Gln Leu
545                 550                 555                 560 
Glu Asp Ala Arg Lys Glu Gly Asp Asn Lys Glu Ile Val Ile Asn Ile
                565                 570                 575     
His Arg Asp Cys Leu Glu Asn Gly Lys Glu Asp Leu Leu Glu Glu Arg
            580                 585                 590         
Asn Lys Glu Leu Met Lys Glu Tyr Asn Tyr Leu Lys Glu Lys Leu Leu
        595                 600                 605             
Gln Cys Glu Lys Glu Lys Ala Glu Arg Glu Val Ile Val Arg Glu Phe
    610                 615                 620                 
Gln Glu Glu Leu Val Asp His Leu Lys Thr Phe Ser Ile Ser Glu Ser
625                 630                 635                 640 
Pro Leu Glu Gly Thr Ser His Cys His Ile Asn Leu Asn Glu Thr Trp
                645                 650                 655     
Thr Ser Lys Lys Lys Leu Phe Gln Val Glu Ile Gln Pro Glu Glu Lys
            660                 665                 670         
His Glu Glu Phe Arg Lys Leu Phe Glu Leu Ile Ser Leu Leu Asn Tyr
        675                 680                 685             
Thr Ala Asp Gln Ile Arg Lys Lys Asn Arg Glu Leu Glu Glu Glu Ala
    690                 695                 700                 
Thr Gly Tyr Lys Lys Cys Leu Glu Met Thr Ile Asn Met Leu Asn Ala
705                 710                 715                 720 
Phe Ala Asn Glu Asp Phe Asn Cys His Gly Asp Leu Asn Thr Asp Gln
                725                 730                 735     
Leu Lys Met Asp Ile Leu Phe Lys Lys Leu Lys Gln Lys Phe Asn Asp
            740                 745                 750         
Leu Val Ala Glu Lys Glu Ala Val Ser Ser Glu Cys Val Asn Leu Ala
        755                 760                 765             
Lys Asp Asn Glu Val Leu His Gln Glu Leu Leu Ser Met Arg Asn Val
    770                 775                 780                 
Gln Glu Lys Cys Glu Lys Leu Glu Lys Asp Lys Lys Met Leu Glu Glu
785                 790                 795                 800 
Glu Val Leu Asn Leu Lys Thr His Met Glu Lys Asp Met Val Glu Leu
                805                 810                 815     
Gly Lys Leu Gln Glu Tyr Lys Ser Glu Leu Asp Glu Arg Ala Val Gln
            820                 825                 830         
Glu Ile Glu Lys Leu Glu Glu Ile His Leu Gln Lys Gln Ala Glu Tyr
        835                 840                 845             
Glu Lys Gln Leu Glu Gln Leu Asn Lys Asp Asn Thr Ala Ser Leu Lys
    850                 855                 860                 
Lys Lys Glu Leu Thr Leu Lys Asp Val Glu Cys Lys Phe Ser Lys Met
865                 870                 875                 880 
Lys Thr Ala Tyr Glu Glu Val Thr Thr Glu Leu Glu Glu Phe Lys Glu
                885                 890                 895     
Val Phe Ala Ala Ala Val Lys Ala Asn Asn Ser Met Ser Lys Lys Leu
            900                 905                 910         
Met Lys Ser Asp Lys Lys Ile Ala Val Ile Ser Thr Lys Leu Phe Thr
        915                 920                 925             
Glu Lys Gln Arg Met Lys Tyr Phe Leu Ser Thr Leu Pro Thr Arg Pro
    930                 935                 940                 
Glu Pro Glu Leu Pro Cys Val Glu Asn Leu Asn Ser Ile Glu Leu Asn
945                 950                 955                 960 
Arg Lys Tyr Ile Pro Lys Thr Ala Ile Arg Ile Pro Thr Ser Asn Pro
                965                 970                 975     
Gln Thr Ser Asn Asn Cys Lys Asn Phe Leu Thr Glu Val Leu Leu Cys
            980                 985                 990         


<210> 5734
<211> 657
<212> PRT
<213> Homo sapiens

<400> 5734
Met Ala Glu Gly Ser Gly Glu Val Val Ala Val Ser Ala Thr Gly Ala
 1               5                  10                  15      
Ala Asn Gly Leu Asn Asn Gly Ala Gly Gly Thr Ser Ala Thr Thr Cys
            20                  25                  30          
Asn Pro Leu Ser Arg Lys Leu His Lys Ile Leu Glu Thr Arg Leu Asp
        35                  40                  45              
Asn Asp Lys Glu Met Leu Glu Ala Leu Lys Ala Leu Ser Thr Phe Phe
    50                  55                  60                  
Val Glu Asn Ser Leu Arg Thr Arg Arg Asn Leu Arg Gly Asp Ile Glu
65                  70                  75                  80  
Arg Lys Ser Leu Ala Ile Asn Glu Glu Phe Val Ser Ile Phe Lys Glu
                85                  90                  95      
Val Lys Glu Glu Leu Glu Ser Ile Ser Glu Asp Val Gln Ala Met Ser
            100                 105                 110         
Asn Cys Cys Gln Asp Met Thr Ser Arg Leu Gln Ala Ala Lys Glu Gln
        115                 120                 125             
Thr Gln Asp Leu Ile Val Lys Thr Thr Lys Leu Gln Ser Glu Ser Gln
    130                 135                 140                 
Lys Leu Glu Ile Arg Ala Gln Val Ala Asp Ala Phe Leu Ser Lys Phe
145                 150                 155                 160 
Gln Leu Thr Ser Asp Glu Met Ser Leu Leu Arg Gly Thr Arg Glu Gly
                165                 170                 175     
Pro Ile Thr Glu Asp Phe Phe Lys Ala Leu Gly Arg Val Lys Gln Ile
            180                 185                 190         
His Asn Asp Val Lys Val Leu Leu Arg Thr Asn Gln Gln Thr Ala Gly
        195                 200                 205             
Leu Glu Ile Met Glu Gln Met Ala Leu Leu Gln Glu Thr Ala Tyr Glu
    210                 215                 220                 
Arg Leu Tyr Arg Trp Ala Gln Ser Glu Cys Arg Thr Leu Thr Gln Glu
225                 230                 235                 240 
Ser Cys Asp Val Ser Pro Val Leu Thr Gln Ala Met Glu Ala Leu Gln
                245                 250                 255     
Asp Arg Pro Val Leu Tyr Lys Tyr Thr Leu Asp Glu Phe Gly Thr Ala
            260                 265                 270         
Arg Arg Ser Thr Val Val Arg Gly Phe Ile Asp Ala Leu Thr Arg Gly
        275                 280                 285             
Gly Pro Gly Gly Thr Pro Arg Pro Ile Glu Met His Ser His Asp Pro
    290                 295                 300                 
Leu Arg Tyr Val Gly Asp Met Leu Ala Trp Leu His Gln Ala Thr Ala
305                 310                 315                 320 
Ser Glu Lys Glu His Leu Glu Ala Leu Leu Lys His Val Thr Thr Gln
                325                 330                 335     
Gly Val Glu Glu Asn Ile Gln Glu Val Val Gly His Ile Thr Glu Gly
            340                 345                 350         
Val Cys Arg Pro Leu Lys Val Arg Ile Glu Gln Val Ile Val Ala Glu
        355                 360                 365             
Pro Gly Ala Val Leu Leu Tyr Lys Ile Ser Asn Leu Leu Lys Phe Tyr
    370                 375                 380                 
His His Thr Ile Ser Gly Ile Val Gly Asn Ser Ala Thr Ala Leu Leu
385                 390                 395                 400 
Thr Thr Ile Glu Glu Met His Leu Leu Ser Lys Lys Ile Phe Phe Asn
                405                 410                 415     
Ser Leu Ser Leu His Ala Ser Lys Leu Met Asp Lys Val Glu Leu Pro
            420                 425                 430         
Pro Pro Asp Leu Gly Pro Ser Ser Ala Leu Asn Gln Thr Leu Met Leu
        435                 440                 445             
Leu Arg Glu Val Leu Ala Ser His Asp Ser Ser Val Val Pro Leu Asp
    450                 455                 460                 
Ala Arg Gln Ala Asp Phe Val Gln Val Leu Ser Cys Val Leu Asp Pro
465                 470                 475                 480 
Leu Leu Gln Met Cys Thr Val Ser Ala Ser Asn Leu Gly Thr Ala Asp
                485                 490                 495     
Met Ala Thr Phe Met Val Asn Ser Leu Tyr Met Met Lys Thr Thr Leu
            500                 505                 510         
Ala Leu Phe Glu Phe Thr Asp Arg Arg Leu Glu Met Leu Gln Phe Gln
        515                 520                 525             
Ile Glu Ala His Leu Asp Thr Leu Ile Asn Glu Gln Ala Ser Tyr Val
    530                 535                 540                 
Leu Thr Arg Val Gly Leu Ser Tyr Ile Tyr Asn Thr Val Gln Gln His
545                 550                 555                 560 
Lys Pro Glu Gln Gly Ser Leu Ala Asn Met Pro Asn Leu Asp Ser Val
                565                 570                 575     
Thr Leu Lys Ala Ala Met Val Gln Phe Asp Arg Tyr Leu Ser Ala Pro
            580                 585                 590         
Asp Asn Leu Leu Ile Pro Gln Leu Asn Phe Leu Leu Ser Ala Thr Val
        595                 600                 605             
Lys Glu Gln Ile Val Lys Gln Ser Thr Glu Leu Val Cys Arg Ala Tyr
    610                 615                 620                 
Gly Glu Val Tyr Ala Ala Val Met Asn Pro Ile Asn Glu Tyr Lys Asp
625                 630                 635                 640 
Pro Glu Asn Ile Leu His Arg Ser Pro Gln Gln Val Gln Thr Leu Leu
                645                 650                 655     
Ser
    


<210> 5735
<211> 1391
<212> PRT
<213> Homo sapiens

<400> 5735
Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro
 1               5                  10                  15      
Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val
            20                  25                  30          
Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp
        35                  40                  45              
Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala
    50                  55                  60                  
Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val
65                  70                  75                  80  
Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro
                85                  90                  95      
Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg
            100                 105                 110         
Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr
        115                 120                 125             
Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys
    130                 135                 140                 
Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr
145                 150                 155                 160 
Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His
                165                 170                 175     
Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser
            180                 185                 190         
Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys
        195                 200                 205             
Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg
    210                 215                 220                 
Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val
225                 230                 235                 240 
Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Ser
                245                 250                 255     
Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser
            260                 265                 270         
Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu
        275                 280                 285             
Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp
    290                 295                 300                 
Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly
305                 310                 315                 320 
Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe
                325                 330                 335     
Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr
            340                 345                 350         
Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His
        355                 360                 365             
Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu
    370                 375                 380                 
Val Asn Asp His Leu Leu Asn Phe Val Gly Glu Arg Thr Leu Asp Lys
385                 390                 395                 400 
Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr
                405                 410                 415     
Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln
            420                 425                 430         
Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser
        435                 440                 445             
Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val
    450                 455                 460                 
Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu
465                 470                 475                 480 
Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp
                485                 490                 495     
Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu
            500                 505                 510         
Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys
        515                 520                 525             
Val Met Val Ile Thr Arg Ser Leu Pro Asp Pro Gly Lys Ala Gln Asp
    530                 535                 540                 
Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg
545                 550                 555                 560 
Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala
                565                 570                 575     
Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln
            580                 585                 590         
Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile
        595                 600                 605             
Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln
    610                 615                 620                 
Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val
625                 630                 635                 640 
Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu
                645                 650                 655     
Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser
            660                 665                 670         
Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala
        675                 680                 685             
Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro
    690                 695                 700                 
His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys
705                 710                 715                 720 
Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile
                725                 730                 735     
Phe Ser Ser Lys Glu Ala Gln Phe Ala Gln Ile Phe Glu Pro Leu His
            740                 745                 750         
Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val
        755                 760                 765             
Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro
    770                 775                 780                 
Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn
785                 790                 795                 800 
Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu
                805                 810                 815     
Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met
            820                 825                 830         
Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr
        835                 840                 845             
Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu
    850                 855                 860                 
Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu
865                 870                 875                 880 
Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His
                885                 890                 895     
Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn
            900                 905                 910         
Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys
        915                 920                 925             
Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala
    930                 935                 940                 
Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln
945                 950                 955                 960 
Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His
                965                 970                 975     
Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val
            980                 985                 990         
Pro Tyr Thr Ile His Leu Leu Ala His Asp Pro Asp Tyr Val Lys Val
        995                 1000                1005            
Gln Asp Ile Glu Gln Leu Lys Asp Val Lys Glu Cys Leu Trp Phe Val
    1010                1015                1020                
Leu Glu Ile Leu Met Ala Lys Asn Glu Asn Asn Ser His Ala Phe Ile
1025                1030                1035                1040
Arg Lys Met Val Glu Asn Ile Lys Gln Thr Lys Asp Ala Gln Gly Pro
                1045                1050                1055    
Asp Asp Ala Lys Met Asn Glu Lys Leu Tyr Thr Val Cys Asp Val Ala
            1060                1065                1070        
Met Asn Ile Ile Met Ser Lys Ser Thr Thr Tyr Ser Leu Glu Ser Pro
        1075                1080                1085            
Lys Asp Pro Val Leu Pro Ala Arg Phe Phe Thr Gln Pro Asp Lys Asn
    1090                1095                1100                
Phe Ser Asn Thr Lys Asn Tyr Leu Pro Pro Gly Met Lys Ser Phe Phe
1105                1110                1115                1120
Thr Pro Gly Lys Pro Lys Thr Thr Asn Val Leu Gly Ala Val Asn Lys
                1125                1130                1135    
Pro Leu Ser Ser Ala Gly Lys Gln Ser Gln Thr Lys Ser Ser Arg Met
            1140                1145                1150        
Glu Thr Val Gly Asn Ala Ser Ser Ser Ser Asn Pro Ser Ser Pro Gly
        1155                1160                1165            
Arg Ile Lys Gly Arg Leu Asp Ser Ser Glu Met Asp His Ser Glu Asn
    1170                1175                1180                
Glu Asp Tyr Thr Met Ser Ser Pro Leu Pro Gly Lys Arg Ser Asp Lys
1185                1190                1195                1200
Arg Asp Asp Ser Asp Leu Val Arg Ser Glu Leu Glu Lys Pro Arg Gly
                1205                1210                1215    
Arg Lys Lys Thr Pro Val Thr Glu Arg Glu Glu Lys Leu Gly Met Asp
            1220                1225                1230        
Asp Leu Thr Lys Leu Val Gln Glu Gln Arg Pro Lys Gly Ser Gln Arg
        1235                1240                1245            
Ser Arg Lys Arg Gly His Thr Ala Ser Glu Ser Asp Glu Gln Gln Trp
    1250                1255                1260                
Pro Glu Glu Lys Arg Leu Lys Glu Asp Ile Leu Glu Asn Glu Asp Glu
1265                1270                1275                1280
Gln Asn Ser Pro Pro Lys Lys Gly Lys Arg Gly Arg Pro Pro Lys Pro
                1285                1290                1295    
Leu Gly Gly Gly Thr Pro Lys Glu Glu Pro Thr Met Lys Thr Ser Lys
            1300                1305                1310        
Lys Gly Ser Lys Lys Lys Ser Gly Pro Pro Ala Pro Glu Glu Glu Glu
        1315                1320                1325            
Glu Glu Glu Arg Gln Ser Gly Asn Thr Glu Gln Lys Ser Lys Ser Lys
    1330                1335                1340                
Gln His Arg Val Ser Arg Arg Ala Gln Gln Arg Ala Glu Ser Ser Glu
1345                1350                1355                1360
Ser Ser Ala Ile Glu Ser Thr Gln Ser Thr Pro Gln Lys Gly Arg Gly
                1365                1370                1375    
Arg Pro Ser Lys Thr Pro Ser Pro Ser Gln Pro Lys Lys Asn Val
            1380                1385                1390    


<210> 5736
<211> 379
<212> PRT
<213> Homo sapiens

<400> 5736
Met Glu Gln Leu Ser Ser Ala Asn Thr Arg Phe Ala Leu Asp Leu Phe
 1               5                  10                  15      
Leu Ala Leu Ser Glu Asn Asn Pro Ala Gly Asn Ile Phe Ile Ser Pro
            20                  25                  30          
Phe Ser Ile Ser Ser Ala Met Ala Met Val Phe Leu Gly Thr Arg Gly
        35                  40                  45              
Asn Thr Ala Ala Gln Leu Ser Lys Thr Phe His Phe Asn Thr Val Glu
    50                  55                  60                  
Glu Val His Ser Arg Phe Gln Ser Leu Asn Ala Asp Ile Asn Lys Arg
65                  70                  75                  80  
Gly Ala Ser Tyr Ile Leu Lys Leu Ala Asn Arg Leu Tyr Gly Glu Lys
                85                  90                  95      
Thr Tyr Asn Phe Leu Pro Glu Phe Leu Val Ser Thr Gln Lys Thr Tyr
            100                 105                 110         
Gly Ala Asp Leu Ala Ser Val Asp Phe Gln His Ala Ser Glu Asp Ala
        115                 120                 125             
Arg Lys Thr Ile Asn Gln Trp Val Lys Gly Gln Thr Glu Gly Lys Ile
    130                 135                 140                 
Pro Glu Leu Leu Ala Ser Gly Met Val Asp Asn Met Thr Lys Leu Val
145                 150                 155                 160 
Leu Val Asn Ala Ile Tyr Phe Lys Gly Asn Trp Lys Asp Lys Phe Met
                165                 170                 175     
Lys Glu Ala Thr Thr Asn Ala Pro Phe Arg Leu Asn Lys Lys Asp Arg
            180                 185                 190         
Lys Thr Val Lys Met Met Tyr Gln Lys Lys Lys Phe Ala Tyr Gly Tyr
        195                 200                 205             
Ile Glu Asp Leu Lys Cys Arg Val Leu Glu Leu Pro Tyr Gln Gly Glu
    210                 215                 220                 
Glu Leu Ser Met Val Ile Leu Leu Pro Asp Asp Ile Glu Asp Glu Ser
225                 230                 235                 240 
Thr Gly Leu Lys Lys Ile Glu Glu Gln Leu Thr Leu Glu Lys Leu His
                245                 250                 255     
Glu Trp Thr Lys Pro Glu Asn Leu Asp Phe Ile Glu Val Asn Val Ser
            260                 265                 270         
Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu
        275                 280                 285             
Ala Arg Leu Gly Val Gln Asp Leu Phe Asn Ser Ser Lys Ala Asp Leu
    290                 295                 300                 
Ser Gly Met Ser Gly Ala Arg Asp Ile Phe Ile Ser Lys Ile Val His
305                 310                 315                 320 
Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala
                325                 330                 335     
Thr Ala Gly Ile Ala Thr Phe Cys Met Leu Met Pro Glu Glu Asn Phe
            340                 345                 350         
Thr Ala Asp His Pro Phe Leu Phe Phe Ile Arg His Asn Ser Ser Gly
        355                 360                 365             
Ser Ile Leu Phe Leu Gly Arg Phe Ser Ser Pro
    370                 375                 


<210> 5737
<211> 190
<212> PRT
<213> Homo sapiens

<400> 5737
Met Glu Ala Glu Thr Lys Thr Leu Pro Leu Glu Asn Ala Ser Ile Leu
 1               5                  10                  15      
Ser Glu Gly Ser Leu Gln Glu Gly His Arg Leu Trp Ile Gly Asn Leu
            20                  25                  30          
Asp Pro Lys Ile Thr Glu Tyr His Leu Leu Lys Leu Leu Gln Lys Phe
        35                  40                  45              
Gly Lys Val Lys Gln Phe Asp Phe Leu Phe His Lys Ser Gly Ala Leu
    50                  55                  60                  
Glu Gly Gln Pro Arg Gly Tyr Cys Phe Val Asn Phe Glu Thr Lys Gln
65                  70                  75                  80  
Glu Ala Glu Gln Ala Ile Gln Cys Leu Asn Gly Lys Leu Ala Leu Ser
                85                  90                  95      
Lys Lys Leu Val Val Arg Trp Ala His Ala Gln Val Lys Arg Tyr Asp
            100                 105                 110         
His Asn Lys Asn Asp Lys Ile Leu Pro Ile Ser Leu Glu Pro Ser Ser
        115                 120                 125             
Ser Thr Glu Pro Thr Gln Ser Asn Leu Ser Val Thr Ala Lys Ile Lys
    130                 135                 140                 
Ala Ile Glu Ala Lys Leu Lys Met Met Ala Glu Asn Pro Asp Ala Glu
145                 150                 155                 160 
Tyr Pro Ala Ala Pro Val Tyr Ser Tyr Phe Lys Pro Pro Asp Lys Lys
                165                 170                 175     
Arg Thr Thr Pro Tyr Ser Arg Thr Ala Trp Lys Ser Arg Arg
            180                 185                 190 


<210> 5738
<211> 690
<212> PRT
<213> Homo sapiens

<400> 5738
Met Glu Lys Ile Leu Gln Met Ala Glu Gly Ile Asp Ile Gly Glu Met
 1               5                  10                  15      
Pro Ser Tyr Asp Leu Val Leu Ser Lys Pro Ser Lys Gly Gln Lys Arg
            20                  25                  30          
His Leu Ser Thr Cys Asp Gly Gln Asn Pro Pro Lys Lys Gln Ala Gly
        35                  40                  45              
Ser Lys Phe His Ala Arg Pro Arg Phe Glu Pro Val His Phe Val Ala
    50                  55                  60                  
Ser Ser Ser Lys Asp Glu Arg Gln Glu Asp Pro Tyr Gly Pro Gln Thr
65                  70                  75                  80  
Lys Glu Val Asn Glu Gln Thr His Phe Ala Ser Met Pro Arg Asp Ile
                85                  90                  95      
Tyr Gln Asp Tyr Thr Gln Asp Ser Phe Ser Ile Gln Asp Gly Asn Ser
            100                 105                 110         
Gln Tyr Cys Asp Ser Ser Gly Phe Ile Leu Thr Lys Asp Gln Pro Val
        115                 120                 125             
Thr Ala Asn Met Tyr Phe Asp Ser Gly Asn Pro Ala Pro Ser Thr Thr
    130                 135                 140                 
Ser Gln Gln Ala Asn Ser Gln Ser Thr Pro Glu Pro Ser Pro Ser Gln
145                 150                 155                 160 
Thr Phe Pro Glu Ser Val Val Ala Glu Lys Gln Tyr Phe Ile Glu Lys
                165                 170                 175     
Leu Thr Ala Thr Ile Trp Lys Asn Leu Ser Asn Pro Glu Met Thr Ser
            180                 185                 190         
Gly Ser Asp Lys Ile Asn Tyr Thr Tyr Met Leu Thr Arg Cys Ile Gln
        195                 200                 205             
Ala Cys Lys Thr Asn Pro Glu Tyr Ile Tyr Ala Pro Leu Lys Glu Ile
    210                 215                 220                 
Pro Pro Ala Asp Ile Pro Lys Asn Lys Lys Leu Leu Thr Asp Gly Tyr
225                 230                 235                 240 
Ala Cys Glu Val Arg Cys Gln Asn Ile Tyr Leu Thr Thr Gly Tyr Ala
                245                 250                 255     
Gly Ser Lys Asn Gly Ser Arg Asp Arg Ala Thr Glu Leu Ala Val Lys
            260                 265                 270         
Leu Leu Gln Lys Arg Ile Glu Val Arg Val Val Arg Arg Lys Phe Lys
        275                 280                 285             
His Thr Phe Gly Glu Asp Leu Val Val Cys Gln Ile Gly Met Ser Ser
    290                 295                 300                 
Tyr Glu Phe Pro Pro Ala Leu Lys Pro Pro Glu Asp Leu Val Val Leu
305                 310                 315                 320 
Gly Lys Asp Ala Ser Gly Gln Pro Ile Phe Asn Ala Ser Ala Lys His
                325                 330                 335     
Trp Thr Asn Phe Val Ile Thr Glu Asn Ala Asn Asp Ala Ile Gly Ile
            340                 345                 350         
Leu Asn Asn Ser Ala Ser Phe Asn Lys Met Ser Ile Glu Tyr Lys Tyr
        355                 360                 365             
Glu Met Met Pro Asn Arg Thr Trp Arg Cys Arg Val Phe Leu Gln Asp
    370                 375                 380                 
His Cys Leu Ala Glu Gly Tyr Gly Thr Lys Lys Thr Ser Lys His Ala
385                 390                 395                 400 
Ala Ala Asp Glu Ala Leu Lys Ile Leu Gln Lys Thr Gln Pro Thr Tyr
                405                 410                 415     
Pro Ser Val Lys Ser Ser Gln Cys His Thr Gly Ser Ser Pro Arg Gly
            420                 425                 430         
Ser Gly Lys Lys Lys Asp Ile Lys Asp Leu Val Val Tyr Glu Asn Ser
        435                 440                 445             
Ser Asn Pro Val Cys Thr Leu Asn Asp Thr Ala Gln Phe Asn Arg Met
    450                 455                 460                 
Thr Val Glu Tyr Val Tyr Glu Arg Met Thr Gly Leu Arg Trp Lys Cys
465                 470                 475                 480 
Lys Val Ile Leu Glu Ser Glu Val Ile Ala Glu Ala Val Gly Val Lys
                485                 490                 495     
Lys Thr Val Lys Tyr Glu Ala Ala Gly Glu Ala Val Lys Thr Leu Lys
            500                 505                 510         
Lys Thr Gln Pro Thr Val Ile Asn Asn Leu Lys Lys Gly Ala Val Glu
        515                 520                 525             
Asp Val Ile Ser Arg Asn Glu Ile Gln Gly Arg Ser Ala Glu Glu Ala
    530                 535                 540                 
Tyr Lys Gln Gln Ile Lys Glu Asp Asn Ile Gly Asn Gln Leu Leu Arg
545                 550                 555                 560 
Lys Met Gly Trp Thr Gly Gly Gly Leu Gly Lys Ser Gly Glu Gly Ile
                565                 570                 575     
Arg Glu Pro Ile Ser Val Lys Glu Gln His Lys Arg Glu Gly Leu Gly
            580                 585                 590         
Leu Asp Val Glu Arg Val Asn Lys Ile Ala Lys Arg Asp Ile Glu Gln
        595                 600                 605             
Ile Ile Arg Asn Tyr Ala Arg Ser Glu Ser His Thr Asp Leu Thr Phe
    610                 615                 620                 
Ser Arg Glu Leu Thr Asn Asp Glu Arg Lys Gln Ile His Gln Ile Ala
625                 630                 635                 640 
Gln Lys Tyr Gly Leu Lys Ser Lys Ser His Gly Val Gly His Asp Arg
                645                 650                 655     
Tyr Leu Val Val Gly Arg Lys Arg Arg Lys Glu Asp Leu Leu Asp Gln
            660                 665                 670         
Leu Lys Gln Glu Gly Gln Val Gly His Tyr Glu Leu Val Met Pro Gln
        675                 680                 685             
Ala Asn
    690 


<210> 5739
<211> 467
<212> PRT
<213> Homo sapiens

<400> 5739
Met Pro Gly Arg Trp Arg Trp Gln Arg Asp Met His Pro Ala Arg Lys
 1               5                  10                  15      
Leu Leu Ser Leu Leu Phe Leu Ile Leu Met Gly Thr Glu Leu Thr Gln
            20                  25                  30          
Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser Ser Ala
        35                  40                  45              
Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro Gln Gln
    50                  55                  60                  
Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln Leu Leu
65                  70                  75                  80  
Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp Arg Arg
                85                  90                  95      
Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln Met Lys
            100                 105                 110         
Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys Gln His
        115                 120                 125             
Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu Leu Arg
    130                 135                 140                 
Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys Leu Val
145                 150                 155                 160 
Leu Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu Asn Glu
                165                 170                 175     
Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln Ser Arg
            180                 185                 190         
Val Ser Asn Leu Glu Glu Arg Leu Arg Ala Cys Met Gln Lys Leu Ala
        195                 200                 205             
Cys Gly Lys Leu Thr Gly Ile Ser Asp Pro Val Thr Val Lys Thr Ser
    210                 215                 220                 
Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Pro Leu Ala Pro Glu Gly
225                 230                 235                 240 
Asp Asn Arg Val Trp Tyr Met Asp Gly Tyr His Asn Asn Arg Phe Val
                245                 250                 255     
Arg Glu Tyr Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn Phe Thr
            260                 265                 270         
Ser His Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val Val Tyr
        275                 280                 285             
Asn Gly Ser Ile Tyr Phe Asn Lys Phe Gln Ser His Ile Ile Ile Arg
    290                 295                 300                 
Phe Asp Leu Lys Thr Glu Thr Ile Leu Lys Thr Arg Ser Leu Asp Tyr
305                 310                 315                 320 
Ala Gly Tyr Asn Asn Met Tyr His Tyr Ala Trp Gly Gly His Ser Asp
                325                 330                 335     
Ile Asp Leu Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr Ala Thr
            340                 345                 350         
Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro Val Ser
        355                 360                 365             
Leu Gln Thr Leu Gln Thr Trp Asn Thr Ser Tyr Pro Lys Arg Ser Ala
    370                 375                 380                 
Gly Glu Ala Phe Ile Ile Cys Gly Thr Leu Tyr Val Thr Asn Gly Tyr
385                 390                 395                 400 
Ser Gly Gly Thr Lys Val His Tyr Ala Tyr Gln Thr Asn Ala Ser Thr
                405                 410                 415     
Tyr Glu Tyr Ile Asp Ile Pro Phe Gln Asn Lys Tyr Ser His Ile Ser
            420                 425                 430         
Met Leu Asp Tyr Asn Pro Lys Asp Arg Ala Leu Tyr Ala Trp Asn Asn
        435                 440                 445             
Gly His Gln Ile Leu Tyr Asn Val Thr Leu Phe His Val Ile Arg Ser
    450                 455                 460                 
Asp Glu Leu
465         


<210> 5740
<211> 485
<212> PRT
<213> Homo sapiens

<400> 5740
Met Ser Val Pro Leu Leu Lys Ile Gly Val Val Leu Ser Thr Met Ala
 1               5                  10                  15      
Met Ile Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu
            20                  25                  30          
Asn Thr Thr Arg Leu Ser Ala Ala Ser Gly Gly Thr Leu Asp Arg Ser
        35                  40                  45              
Thr Gly Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser
    50                  55                  60                  
Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro
65                  70                  75                  80  
Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln
                85                  90                  95      
Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp
            100                 105                 110         
Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln
        115                 120                 125             
Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys
    130                 135                 140                 
Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu
145                 150                 155                 160 
Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys
                165                 170                 175     
Leu Val Leu Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu
            180                 185                 190         
Asn Glu Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln
        195                 200                 205             
Ser Arg Val Ser Asn Leu Glu Glu Arg Leu Arg Ala Cys Met Gln Lys
    210                 215                 220                 
Leu Ala Cys Gly Lys Leu Thr Gly Ile Ser Asp Pro Val Thr Val Lys
225                 230                 235                 240 
Thr Ser Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Pro Leu Ala Pro
                245                 250                 255     
Glu Gly Asp Asn Arg Val Trp Tyr Met Asp Gly Tyr His Asn Asn Arg
            260                 265                 270         
Phe Val Arg Glu Tyr Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn
        275                 280                 285             
Phe Thr Ser His Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val
    290                 295                 300                 
Val Tyr Asn Gly Ser Ile Tyr Phe Asn Lys Phe Gln Ser His Ile Ile
305                 310                 315                 320 
Ile Arg Phe Asp Leu Lys Thr Glu Thr Ile Leu Lys Thr Arg Ser Leu
                325                 330                 335     
Asp Tyr Ala Gly Tyr Asn Asn Met Tyr His Tyr Ala Trp Gly Gly His
            340                 345                 350         
Ser Asp Ile Asp Leu Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr
        355                 360                 365             
Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro
    370                 375                 380                 
Val Ser Leu Gln Thr Leu Gln Thr Trp Asn Thr Ser Tyr Pro Lys Arg
385                 390                 395                 400 
Ser Ala Gly Glu Ala Phe Ile Ile Cys Gly Thr Leu Tyr Val Thr Asn
                405                 410                 415     
Gly Tyr Ser Gly Gly Thr Lys Val His Tyr Ala Tyr Gln Thr Asn Ala
            420                 425                 430         
Ser Thr Tyr Glu Tyr Ile Asp Ile Pro Phe Gln Asn Lys Tyr Ser His
        435                 440                 445             
Ile Ser Met Leu Asp Tyr Asn Pro Lys Asp Arg Ala Leu Tyr Ala Trp
    450                 455                 460                 
Asn Asn Gly His Gln Ile Leu Tyr Asn Val Thr Leu Phe His Val Ile
465                 470                 475                 480 
Arg Ser Asp Glu Leu
                485 


<210> 5741
<211> 390
<212> PRT
<213> Homo sapiens

<400> 5741
Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu
 1               5                  10                  15      
Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr
            20                  25                  30          
Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala
        35                  40                  45              
Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser
    50                  55                  60                  
Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu
65                  70                  75                  80  
Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu
                85                  90                  95      
Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu
            100                 105                 110         
Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr
        115                 120                 125             
His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val
    130                 135                 140                 
Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu
145                 150                 155                 160 
Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn
                165                 170                 175     
Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser
            180                 185                 190         
Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu
        195                 200                 205             
Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser
    210                 215                 220                 
Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr
225                 230                 235                 240 
Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro
                245                 250                 255     
Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln
            260                 265                 270         
Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser
        275                 280                 285             
Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys
    290                 295                 300                 
Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn
305                 310                 315                 320 
Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr
                325                 330                 335     
Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala
            340                 345                 350         
Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr
        355                 360                 365             
Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val
    370                 375                 380                 
Arg Ser Cys Lys Cys Ser
385                 390 


<210> 5742
<211> 292
<212> PRT
<213> Homo sapiens

<400> 5742
Met Ala Leu Ala Ala Leu Met Ile Ala Leu Gly Ser Leu Gly Leu His
 1               5                  10                  15      
Thr Trp Gln Ala Gln Ala Val Pro Thr Ile Leu Pro Leu Gly Leu Ala
            20                  25                  30          
Pro Asp Thr Phe Asp Asp Thr Tyr Val Gly Cys Ala Glu Glu Met Glu
        35                  40                  45              
Glu Lys Ala Ala Pro Leu Leu Lys Glu Glu Met Ala His His Ala Leu
    50                  55                  60                  
Leu Arg Glu Ser Trp Glu Ala Ala Gln Glu Thr Trp Glu Asp Lys Arg
65                  70                  75                  80  
Arg Gly Leu Thr Leu Pro Pro Gly Phe Lys Ala Gln Asn Gly Ile Ala
                85                  90                  95      
Ile Met Val Tyr Thr Asn Ser Ser Asn Thr Leu Tyr Trp Glu Leu Asn
            100                 105                 110         
Gln Ala Val Arg Thr Gly Gly Gly Ser Arg Glu Leu Tyr Met Arg His
        115                 120                 125             
Phe Pro Phe Lys Ala Leu His Phe Tyr Leu Ile Arg Ala Leu Gln Leu
    130                 135                 140                 
Leu Arg Gly Ser Gly Gly Cys Ser Arg Gly Pro Gly Glu Val Val Phe
145                 150                 155                 160 
Arg Gly Val Gly Ser Leu Arg Phe Glu Pro Lys Arg Leu Gly Asp Ser
                165                 170                 175     
Val Arg Leu Gly Gln Phe Ala Ser Ser Ser Leu Asp Lys Ala Val Ala
            180                 185                 190         
His Arg Phe Gly Asn Ala Thr Leu Phe Ser Leu Thr Thr Cys Phe Gly
        195                 200                 205             
Ala Pro Ile Gln Ala Phe Ser Val Phe Pro Lys Glu Arg Glu Val Leu
    210                 215                 220                 
Ile Pro Pro His Glu Val Phe Leu Val Thr Arg Phe Ser Gln Asp Gly
225                 230                 235                 240 
Ala Gln Ser Leu Val Thr Leu Trp Ser Tyr Asn Gln Thr Cys Ser His
                245                 250                 255     
Phe Asn Cys Ala Tyr Leu Gly Gly Glu Lys Arg Arg Gly Cys Val Ser
            260                 265                 270         
Ala Pro Gly Ala Leu Gly Thr Gly Asp Leu His Met Thr Lys Arg His
        275                 280                 285             
Leu Gln Gln Pro
    290         


<210> 5743
<211> 292
<212> PRT
<213> Homo sapiens

<400> 5743
Met Ala Leu Ala Ala Leu Met Ile Ala Leu Gly Ser Leu Gly Leu His
 1               5                  10                  15      
Thr Trp Gln Ala Gln Ala Val Pro Thr Ile Leu Pro Leu Gly Leu Ala
            20                  25                  30          
Pro Asp Thr Phe Asp Asp Thr Tyr Val Gly Cys Val Glu Glu Met Glu
        35                  40                  45              
Glu Lys Ala Ala Pro Leu Leu Lys Glu Glu Met Ala His His Ala Leu
    50                  55                  60                  
Leu Arg Glu Ser Trp Glu Ala Ala Gln Glu Thr Trp Glu Asp Lys Arg
65                  70                  75                  80  
Arg Gly Leu Thr Leu Pro Pro Gly Phe Lys Ala Gln Asn Gly Ile Ala
                85                  90                  95      
Ile Met Val Tyr Thr Asn Ser Ser Asn Thr Leu Tyr Trp Glu Leu Asn
            100                 105                 110         
Gln Ala Val Arg Thr Gly Gly Gly Ser Arg Glu Leu Tyr Met Arg His
        115                 120                 125             
Phe Pro Phe Lys Ala Leu His Phe Tyr Leu Ile Arg Ala Leu Gln Leu
    130                 135                 140                 
Leu Arg Gly Ser Gly Gly Cys Ser Arg Gly Pro Gly Glu Val Val Phe
145                 150                 155                 160 
Arg Gly Val Gly Ser Leu Arg Phe Glu Pro Lys Arg Leu Gly Asp Ser
                165                 170                 175     
Val Arg Leu Gly Gln Phe Ala Ser Ser Ser Leu Asp Lys Ala Val Ala
            180                 185                 190         
His Arg Phe Gly Asn Ala Thr Leu Phe Ser Leu Thr Thr Cys Phe Gly
        195                 200                 205             
Ala Pro Ile Gln Ala Phe Ser Val Phe Pro Lys Glu Arg Glu Val Leu
    210                 215                 220                 
Ile Pro Pro His Glu Val Phe Leu Val Thr Arg Phe Ser Gln Asp Gly
225                 230                 235                 240 
Ala Gln Ser Leu Val Thr Leu Trp Ser Tyr Asn Gln Thr Cys Ser His
                245                 250                 255     
Phe Asn Cys Ala Tyr Leu Gly Gly Glu Lys Arg Arg Gly Cys Val Ser
            260                 265                 270         
Ala Pro Gly Ala Leu Gly Thr Gly Asp Leu His Met Thr Lys Arg His
        275                 280                 285             
Leu Gln Gln Pro
    290         


<210> 5744
<211> 1177
<212> PRT
<213> Homo sapiens

<400> 5744
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val
 1               5                  10                  15      
Ile Ser Phe Leu Pro Asn Thr Glu Gly Phe Ser Arg Ala Ala Leu Pro
            20                  25                  30          
Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp
        35                  40                  45              
Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr
    50                  55                  60                  
Gly Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu
65                  70                  75                  80  
Asn Thr Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Thr Gln Arg
                85                  90                  95      
Cys Asn Asn Arg Thr Gln Cys Ile Val Val Thr Gly Ser Asp Val Phe
            100                 105                 110         
Pro Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu
        115                 120                 125             
Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Thr Leu Lys Ala Ile Val
    130                 135                 140                 
Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys
145                 150                 155                 160 
Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Thr
                165                 170                 175     
Pro Tyr Arg Thr Asp Thr Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe
            180                 185                 190         
Gln Asn Ser Arg Gln Thr Thr Thr Tyr Lys Leu Pro Asn Arg Val Asp
        195                 200                 205             
Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu
    210                 215                 220                 
Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser
225                 230                 235                 240 
Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Thr Ser Pro Tyr
                245                 250                 255     
Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val Asp Glu Asn Gly
            260                 265                 270         
Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Met Ile Val Ile
        275                 280                 285             
Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Ala Thr Trp Glu Thr
    290                 295                 300                 
Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val
305                 310                 315                 320 
Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Thr Gly
                325                 330                 335     
Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Thr Arg Leu Asn Arg Gly Glu
            340                 345                 350         
Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val
        355                 360                 365             
Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe
    370                 375                 380                 
Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val
385                 390                 395                 400 
Pro Thr Thr Ala Val Thr Ile Thr Ser Ser Ala Glu Leu Phe Lys Thr
                405                 410                 415     
Ile Ile Ser Thr Thr Ser Thr Thr Ser Gln Lys Gly Pro Met Ser Thr
            420                 425                 430         
Thr Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro
        435                 440                 445             
Ala Val Ser Thr Thr Lys Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu
    450                 455                 460                 
Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro
465                 470                 475                 480 
Gln Thr Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Thr
                485                 490                 495     
Arg Gly Thr Ala Ser Tyr Leu Cys Met Ile Ser Thr Gly Thr Trp Asn
            500                 505                 510         
Pro Lys Gly Pro Asp Leu Ser Asn Cys Thr Ser His Trp Val Asn Gln
        515                 520                 525             
Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn
    530                 535                 540                 
Glu Leu Ala Lys His Thr Lys Gly Pro Val Phe Ala Gly Asp Val Ser
545                 550                 555                 560 
Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln
                565                 570                 575     
Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr
            580                 585                 590         
Asn Lys Ala Ile Val Asp Thr Val Asp Asn Leu Leu Arg Pro Glu Ala
        595                 600                 605             
Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His Thr Ala
    610                 615                 620                 
Thr Met Leu Leu Asp Thr Leu Glu Glu Gly Ala Phe Val Leu Ala Asp
625                 630                 635                 640 
Asn Leu Leu Glu Pro Thr Arg Val Ser Met Pro Thr Glu Asn Ile Val
                645                 650                 655     
Leu Glu Val Ala Val Leu Ser Thr Glu Gly Gln Ile Gln Asp Phe Lys
            660                 665                 670         
Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala
        675                 680                 685             
Asn Thr Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe
    690                 695                 700                 
Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Thr Glu Asn Ala Thr
705                 710                 715                 720 
Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Thr Ile Ala Val
                725                 730                 735     
Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val
            740                 745                 750         
Tyr Leu Thr Asp Pro Val Leu Phe Thr Leu Pro His Ile Asp Pro Asp
        755                 760                 765             
Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Thr
    770                 775                 780                 
Met Met Gly Tyr Trp Ser Thr Gln Gly Cys Lys Leu Val Asp Thr Asn
785                 790                 795                 800 
Lys Thr Arg Thr Thr Cys Ala Cys Ser His Leu Thr Asn Phe Ala Ile
                805                 810                 815     
Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu
            820                 825                 830         
Leu Leu Thr Val Ile Thr Trp Val Gly Ile Val Ile Ser Leu Val Cys
        835                 840                 845             
Leu Ala Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser
    850                 855                 860                 
Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala
865                 870                 875                 880 
Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Thr Lys Tyr Ala Ile Ala
                885                 890                 895     
Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe
            900                 905                 910         
Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu
        915                 920                 925             
Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly
    930                 935                 940                 
Tyr Leu Phe Pro Ala Thr Val Val Gly Val Ser Ala Ala Ile Asp Tyr
945                 950                 955                 960 
Lys Ser Tyr Gly Thr Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr
                965                 970                 975     
Phe Ile Trp Ser Phe Ile Gly Pro Val Thr Phe Ile Ile Leu Leu Asn
            980                 985                 990         
Ile Ile Phe Leu Val Ile Thr Leu Cys Lys Met Val Lys His Ser Asn
        995                 1000                1005            
Thr Leu Lys Pro Asp Ser Ser Arg Leu Glu Asn Ile Lys Ser Trp Val
    1010                1015                1020                
Leu Gly Ala Phe Ala Leu Leu Cys Leu Leu Gly Leu Thr Trp Ser Phe
1025                1030                1035                1040
Gly Leu Leu Phe Ile Asn Glu Glu Thr Ile Val Met Ala Tyr Leu Phe
                1045                1050                1055    
Thr Ile Phe Asn Ala Phe Gln Gly Val Phe Ile Phe Ile Phe His Cys
            1060                1065                1070        
Ala Leu Gln Lys Lys Val Arg Lys Glu Tyr Gly Lys Cys Phe Arg His
        1075                1080                1085            
Ser Tyr Cys Cys Gly Gly Leu Pro Thr Glu Ser Pro His Ser Ser Val
    1090                1095                1100                
Lys Ala Ser Thr Thr Arg Thr Ser Ala Arg Tyr Ser Ser Gly Thr Gln
1105                1110                1115                1120
Ser Arg Ile Arg Arg Met Trp Asn Asp Thr Val Arg Lys Gln Ser Glu
                1125                1130                1135    
Ser Ser Phe Ile Ser Gly Asp Ile Asn Ser Thr Ser Thr Leu Asn Gln
            1140                1145                1150        
Gly Leu Thr Ser His Gly Leu Arg Ala His Leu Gln Asp Leu Tyr His
        1155                1160                1165            
Leu Glu Leu Leu Leu Gly Gln Ile Ala
    1170                1175        


<210> 5745
<211> 314
<212> PRT
<213> Homo sapiens

<400> 5745
Met Asp Gln Ile Asn His Thr Asn Val Lys Glu Phe Phe Phe Leu Glu
 1               5                  10                  15      
Leu Thr Arg Ser Arg Glu Leu Glu Phe Phe Leu Phe Val Val Phe Phe
            20                  25                  30          
Ala Val Tyr Val Ala Thr Val Leu Gly Asn Ala Leu Ile Val Val Thr
        35                  40                  45              
Ile Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg
    50                  55                  60                  
Asn Lys Ser Val Leu Asp Ile Val Phe Ser Ser Ile Thr Val Pro Lys
65                  70                  75                  80  
Phe Leu Val Asp Leu Leu Ser Asp Arg Lys Thr Ile Ser Tyr Asn Asp
                85                  90                  95      
Cys Met Ala Gln Ile Phe Phe Phe His Phe Ala Gly Gly Ala Asp Ile
            100                 105                 110         
Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Ala Lys
        115                 120                 125             
Pro Leu His Tyr Val Thr Met Met Arg Lys Glu Val Trp Val Ala Leu
    130                 135                 140                 
Val Val Ala Ser Trp Val Ser Gly Gly Leu His Ser Ile Ile Gln Val
145                 150                 155                 160 
Ile Leu Met Leu Pro Phe Pro Phe Cys Gly Pro Asn Thr Leu Asp Ala
                165                 170                 175     
Phe Tyr Cys Tyr Val Leu Gln Val Val Lys Leu Ala Cys Thr Asp Thr
            180                 185                 190         
Phe Ala Leu Glu Leu Phe Met Ile Ser Asn Asn Gly Leu Val Thr Leu
        195                 200                 205             
Leu Trp Phe Leu Leu Leu Leu Gly Ser Tyr Thr Val Ile Leu Val Met
    210                 215                 220                 
Leu Arg Ser His Ser Gly Glu Gly Arg Asn Lys Ala Leu Ser Thr Cys
225                 230                 235                 240 
Thr Ser His Met Leu Val Val Thr Leu His Phe Val Pro Cys Val Tyr
                245                 250                 255     
Ile Tyr Cys Arg Pro Phe Met Thr Leu Pro Met Asp Thr Thr Ile Ser
            260                 265                 270         
Ile Asn Asn Thr Val Ile Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser
        275                 280                 285             
Leu Arg Asn Gln Glu Met Lys Ser Ala Met Gln Arg Leu Gln Arg Arg
    290                 295                 300                 
Leu Gly Pro Ser Glu Ser Arg Lys Trp Gly
305                 310                 


<210> 5746
<211> 1733
<212> PRT
<213> Homo sapiens

<400> 5746
Met Met Glu Gly Asn Gly Thr Glu Asn Ser Cys Ser Arg Thr Arg Gly
 1               5                  10                  15      
Trp Leu Gln Gln Asp Asn Asp Ala Lys Pro Trp Leu Trp Lys Phe Ser
            20                  25                  30          
Asn Cys Phe Ser Arg Pro Glu Gln Thr Leu Pro His Ser Pro Gln Thr
        35                  40                  45              
Lys Glu Tyr Met Glu Asn Lys Lys Val Ala Val Glu Leu Lys Asp Val
    50                  55                  60                  
Pro Ser Pro Leu His Ala Gly Ser Lys Leu Phe Pro Ala Val Pro Leu
65                  70                  75                  80  
Pro Asp Ile Arg Ser Leu Gln Gln Pro Lys Ile Gln Leu Ser Ser Val
                85                  90                  95      
Pro Lys Val Ser Cys Cys Ala His Cys Pro Asn Glu Pro Ser Thr Ser
            100                 105                 110         
Pro Met Arg Phe Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Ser Ser
        115                 120                 125             
Leu Ile His Pro Gly Ala Leu Leu Asp Ser Gln Ser Thr Arg Thr Ile
    130                 135                 140                 
Thr Cys Gln Val Gly Ser Gly Phe Ala Phe Gln Ser Ala Ser Ser Leu
145                 150                 155                 160 
Gln Asn Ala Ser Ala Arg Asn Asn Leu Ala Gly Ile Ala Ser Asp Phe
                165                 170                 175     
Pro Ser Met Cys Leu Glu Ser Asn Leu Ser Ser Cys Lys His Leu Pro
            180                 185                 190         
Cys Cys Gly Lys Leu His Phe Gln Ser Cys His Gly Asn Val His Lys
        195                 200                 205             
Leu His Gln Phe Pro Ser Leu Gln Gly Cys Thr Ser Ala Gly Tyr Phe
    210                 215                 220                 
Pro Cys Ser Asp Phe Thr Ser Gly Ala Pro Gly His Leu Glu Glu His
225                 230                 235                 240 
Ile Ser Gln Ser Glu Leu Thr Pro His Leu Cys Thr Asn Ser Leu His
                245                 250                 255     
Leu Asn Val Val Pro Pro Val Cys Leu Lys Gly Ser Leu Tyr Cys Glu
            260                 265                 270         
Asp Cys Leu Asn Lys Pro Ala Arg Asn Ser Ile Ile Asp Ala Ala Lys
        275                 280                 285             
Val Trp Pro Asn Ile Pro Pro Pro Asn Thr Gln Pro Ala Pro Leu Ala
    290                 295                 300                 
Val Pro Leu Cys Asn Gly Cys Gly Thr Lys Gly Thr Gly Lys Glu Thr
305                 310                 315                 320 
Thr Leu Leu Leu Ala Thr Ser Leu Gly Lys Ala Ala Ser Lys Phe Gly
                325                 330                 335     
Ser Pro Glu Val Ala Val Ala Gly Gln Val Leu Glu Asn Leu Pro Pro
            340                 345                 350         
Ile Gly Val Phe Trp Asp Ile Glu Asn Cys Ser Val Pro Ser Gly Arg
        355                 360                 365             
Ser Ala Thr Ala Val Val Gln Arg Ile Arg Glu Lys Phe Phe Lys Gly
    370                 375                 380                 
His Arg Glu Ala Glu Phe Ile Cys Val Cys Asp Ile Ser Lys Glu Asn
385                 390                 395                 400 
Lys Glu Val Ile Gln Glu Leu Asn Asn Cys Gln Val Thr Val Ala His
                405                 410                 415     
Ile Asn Ala Thr Ala Lys Asn Ala Ala Asp Asp Lys Leu Arg Gln Ser
            420                 425                 430         
Leu Arg Arg Phe Ala Asn Thr His Thr Ala Pro Ala Thr Val Val Leu
        435                 440                 445             
Val Ser Thr Asp Val Asn Phe Ala Leu Glu Leu Ser Asp Leu Arg His
    450                 455                 460                 
Arg His Gly Phe His Ile Ile Leu Val His Lys Asn Gln Ala Ser Glu
465                 470                 475                 480 
Ala Leu Leu His His Ala Asn Glu Leu Ile Arg Phe Glu Glu Phe Ile
                485                 490                 495     
Ser Asp Leu Pro Pro Arg Leu Pro Leu Lys Met Pro Gln Cys His Thr
            500                 505                 510         
Leu Leu Tyr Val Tyr Asn Leu Pro Ala Asn Lys Asp Gly Lys Ser Val
        515                 520                 525             
Ser Asn Arg Leu Arg Arg Leu Ser Asp Asn Cys Gly Gly Lys Val Leu
    530                 535                 540                 
Ser Ile Thr Gly Cys Ser Ala Ile Leu Arg Phe Ile Asn Gln Asp Ser
545                 550                 555                 560 
Ala Glu Arg Ala Gln Lys Arg Met Glu Asn Glu Asp Val Phe Gly Asn
                565                 570                 575     
Arg Ile Ile Val Ser Phe Thr Pro Lys Asn Arg Glu Leu Cys Glu Thr
            580                 585                 590         
Lys Ser Ser Asn Ala Ile Ala Asp Lys Val Lys Ser Pro Lys Lys Leu
        595                 600                 605             
Lys Asn Pro Lys Leu Cys Leu Ile Lys Asp Ala Ser Glu Gln Ser Ser
    610                 615                 620                 
Ser Ala Lys Ala Thr Pro Gly Lys Gly Ser Gln Ala Asn Ser Gly Ser
625                 630                 635                 640 
Ala Thr Lys Asn Thr Asn Val Lys Ser Leu Gln Glu Leu Cys Arg Met
                645                 650                 655     
Glu Ser Lys Thr Gly His Arg Asn Ser Glu His Gln Gln Gly His Leu
            660                 665                 670         
Arg Leu Val Val Pro Thr His Gly Asn Ser Ser Ala Ala Val Ser Thr
        675                 680                 685             
Pro Lys Asn Ser Gly Val Ala Glu Pro Val Tyr Lys Thr Ser Gln Lys
    690                 695                 700                 
Lys Glu Asn Leu Ser Ala Arg Ser Val Thr Ser Ser Pro Val Glu Lys
705                 710                 715                 720 
Lys Asp Lys Glu Glu Thr Val Phe Gln Val Ser Tyr Pro Ser Ala Phe
                725                 730                 735     
Ser Lys Leu Val Ala Ser Arg Gln Val Ser Pro Leu Leu Ala Ser Gln
            740                 745                 750         
Ser Trp Ser Ser Arg Ala Ser Pro Leu Ala Phe Asn Ile Ala Asn Ser
        755                 760                 765             
Ser Ser Glu Ala Asp Cys Pro Asp Pro Phe Ala Asn Gly Ala Asp Val
    770                 775                 780                 
Gln Val Ser Asn Ile Asp Tyr Arg Leu Ser Arg Lys Glu Leu Gln Gln
785                 790                 795                 800 
Leu Leu Gln Glu Ala Phe Ala Arg His Gly Lys Val Lys Ser Val Glu
                805                 810                 815     
Leu Ser Pro His Thr Asp Tyr Gln Leu Lys Ala Val Val Gln Met Glu
            820                 825                 830         
Asn Leu Gln Asp Ala Ile Gly Ala Val Asn Ser Leu His Arg Tyr Lys
        835                 840                 845             
Ile Gly Ser Lys Lys Ile Leu Val Ser Leu Ala Thr Gly Ala Ala Ser
    850                 855                 860                 
Lys Ser Leu Ser Leu Leu Ser Ala Glu Thr Met Ser Val Leu Gln Asp
865                 870                 875                 880 
Ala Pro Ala Cys Cys Leu Pro Leu Phe Lys Phe Thr Asp Ile Tyr Glu
                885                 890                 895     
Lys Lys Phe Gly His Lys Leu Asn Val Ser Asp Leu Tyr Lys Leu Thr
            900                 905                 910         
Asp Thr Val Ala Ile Arg Glu Gln Gly Asn Gly Arg Leu Val Cys Leu
        915                 920                 925             
Leu Pro Ser Ser Gln Ala Arg Gln Ser Pro Leu Gly Ser Ser Gln Ser
    930                 935                 940                 
His Asp Gly Ser Ser Thr Asn Cys Ser Pro Ile Ile Phe Glu Glu Leu
945                 950                 955                 960 
Glu Tyr His Glu Pro Val Cys Arg Gln His Cys Ser Asn Lys Asp Phe
                965                 970                 975     
Ser Glu His Glu Phe Asp Pro Asp Ser Tyr Lys Ile Pro Phe Val Ile
            980                 985                 990         
Leu Ser Leu Lys Thr Phe Ala Pro Gln Val His Ser Leu Leu Gln Thr
        995                 1000                1005            
His Glu Gly Thr Val Pro Leu Leu Ser Phe Pro Asp Cys Tyr Ile Ala
    1010                1015                1020                
Glu Phe Gly Asp Leu Glu Val Val Gln Glu Asn Gln Gly Gly Val Pro
1025                1030                1035                1040
Leu Glu His Phe Ile Thr Cys Val Pro Gly Val Asn Ile Ala Thr Ala
                1045                1050                1055    
Gln Asn Gly Ile Lys Val Val Lys Trp Ile His Asn Lys Pro Pro Pro
            1060                1065                1070        
Pro Asn Thr Asp Pro Trp Leu Leu Arg Ser Lys Ser Pro Val Gly Asn
        1075                1080                1085            
Pro Gln Leu Ile Gln Phe Ser Arg Glu Val Ile Asp Leu Leu Lys Ser
    1090                1095                1100                
Gln Pro Ser Cys Val Ile Pro Ile Ser His Phe Ile Pro Ser Tyr His
1105                1110                1115                1120
His His Phe Ala Lys Gln Cys Arg Val Ser Asp Tyr Gly Tyr Ser Lys
                1125                1130                1135    
Leu Ile Glu Leu Leu Glu Ala Val Pro His Val Leu Gln Ile Leu Gly
            1140                1145                1150        
Met Gly Ser Lys Arg Leu Leu Thr Leu Thr His Arg Ala Gln Val Lys
        1155                1160                1165            
Arg Phe Thr Gln Asp Leu Leu Lys Leu Leu Lys Ser Gln Ala Ser Lys
    1170                1175                1180                
Gln Val Ile Val Arg Glu Phe Ser Gln Ala Tyr His Trp Cys Phe Ser
1185                1190                1195                1200
Lys Asp Trp Asp Val Thr Glu Tyr Gly Val Cys Glu Leu Ile Asp Ile
                1205                1210                1215    
Val Ser Glu Ile Pro Asp Thr Thr Ile Cys Leu Ser Gln Gln Asp Asn
            1220                1225                1230        
Glu Met Val Ile Cys Ile Pro Lys Arg Glu Arg Thr Gln Asp Glu Ile
        1235                1240                1245            
Glu Arg Thr Lys Gln Phe Ser Lys Asp Val Val Asp Leu Leu Arg His
    1250                1255                1260                
Gln Pro His Phe Arg Met Pro Phe Asn Lys Phe Ile Pro Ser Tyr His
1265                1270                1275                1280
His His Phe Gly Arg Gln Cys Lys Leu Ala Tyr Tyr Gly Phe Thr Lys
                1285                1290                1295    
Leu Leu Glu Leu Phe Glu Ala Ile Pro Asp Thr Leu Gln Val Leu Glu
            1300                1305                1310        
Cys Gly Glu Glu Lys Ile Leu Thr Leu Thr Glu Val Glu Arg Phe Lys
        1315                1320                1325            
Ala Leu Ala Ala Gln Phe Val Lys Leu Leu Arg Ser Gln Lys Asp Asn
    1330                1335                1340                
Cys Leu Met Met Thr Asp Leu Leu Thr Glu Tyr Ala Lys Thr Phe Gly
1345                1350                1355                1360
Tyr Thr Phe Arg Leu Gln Asp Tyr Asp Val Ser Ser Ile Ser Ala Leu
                1365                1370                1375    
Thr Gln Lys Leu Cys His Val Val Lys Val Ala Asp Ile Glu Ser Gly
            1380                1385                1390        
Arg Gln Ile Gln Leu Ile Asn Arg Lys Ser Leu Arg Ser Leu Thr Ala
        1395                1400                1405            
Gln Leu Leu Val Leu Leu Met Ser Trp Glu Gly Thr Thr His Leu Ser
    1410                1415                1420                
Val Glu Glu Leu Lys Arg His Tyr Glu Ser Thr His Asn Thr Pro Leu
1425                1430                1435                1440
Asn Pro Cys Glu Tyr Gly Phe Met Thr Leu Thr Glu Leu Leu Lys Ser
                1445                1450                1455    
Leu Pro Tyr Leu Val Glu Val Phe Thr Asn Asp Lys Met Glu Glu Cys
            1460                1465                1470        
Val Lys Leu Thr Ser Leu Tyr Leu Phe Ala Lys Asn Val Arg Ser Leu
        1475                1480                1485            
Leu His Thr Tyr His Tyr Gln Gln Ile Phe Leu His Glu Phe Ser Met
    1490                1495                1500                
Ala Tyr Thr Lys Tyr Val Gly Glu Thr Leu Gln Pro Lys Thr Tyr Gly
1505                1510                1515                1520
His Ser Ser Val Glu Glu Leu Leu Gly Ala Ile Pro Gln Val Val Trp
                1525                1530                1535    
Ile Lys Gly His Gly His Lys Arg Ile Val Val Leu Lys Asn Asp Met
            1540                1545                1550        
Lys Ser Arg Leu Ser Ser Leu Ser Leu Ser Pro Ala Asn His Glu Asn
        1555                1560                1565            
Gln Pro Ser Glu Gly Glu Arg Ile Leu Glu Val Pro Glu Ser His Thr
    1570                1575                1580                
Ala Ser Glu Leu Lys Leu Gly Ala Asp Gly Ser Gly Pro Ser His Thr
1585                1590                1595                1600
Glu Gln Glu Leu Leu Arg Leu Thr Asp Asp Ser Pro Val Asp Leu Leu
                1605                1610                1615    
Cys Ala Pro Val Pro Ser Cys Leu Pro Ser Pro Gln Leu Arg Pro Asp
            1620                1625                1630        
Pro Val Ile Leu Gln Ser Ala Asp Leu Ile Gln Phe Glu Glu Arg Pro
        1635                1640                1645            
Gln Glu Pro Ser Glu Ile Met Ile Leu Asn Gln Glu Glu Lys Met Glu
    1650                1655                1660                
Ile Pro Ile Pro Gly Lys Ser Lys Thr Leu Thr Ser Asp Ser Ser Ser
1665                1670                1675                1680
Ser Cys Ile Ser Ala Ala Val Pro Val Pro Pro Cys Pro Ser Ser Glu
                1685                1690                1695    
Thr Ser Glu Ser Leu Leu Ser Lys Asp Pro Val Glu Ser Pro Ala Lys
            1700                1705                1710        
Lys Gln Pro Lys Asn Arg Val Lys Leu Ala Ala Asn Phe Ser Leu Ala
        1715                1720                1725            
Pro Ile Thr Lys Leu
    1730            


<210> 5747
<211> 1199
<212> PRT
<213> Homo sapiens

<400> 5747
Met Gln Val Thr Val Ala His Ile Asn Ala Thr Ala Lys Asn Ala Ala
 1               5                  10                  15      
Asp Asp Lys Leu Arg Gln Ser Leu Arg Arg Phe Ala Asn Thr His Thr
            20                  25                  30          
Ala Pro Ala Thr Val Val Leu Val Ser Thr Asp Val Asn Phe Ala Leu
        35                  40                  45              
Glu Leu Ser Asp Leu Arg His Arg His Gly Phe His Ile Ile Leu Val
    50                  55                  60                  
His Lys Asn Gln Ala Ser Glu Ala Leu Leu His His Ala Asn Glu Leu
65                  70                  75                  80  
Ile Arg Phe Glu Glu Phe Ile Ser Asp Leu Pro Pro Arg Leu Pro Leu
                85                  90                  95      
Lys Met Pro Gln Cys His Thr Leu Leu Tyr Val Tyr Asn Leu Pro Ala
            100                 105                 110         
Asn Lys Asp Gly Lys Ser Val Ser Asn Arg Leu Arg Arg Leu Ser Asp
        115                 120                 125             
Asn Cys Gly Gly Lys Val Leu Ser Ile Thr Gly Cys Ser Ala Ile Leu
    130                 135                 140                 
Arg Phe Ile Asn Gln Asp Ser Ala Glu Arg Ala Gln Lys Arg Met Glu
145                 150                 155                 160 
Asn Glu Asp Val Phe Glu Lys Lys Asp Lys Glu Glu Thr Val Phe Gln
                165                 170                 175     
Val Ser Tyr Pro Ser Ala Phe Ser Lys Leu Val Ala Ser Arg Gln Val
            180                 185                 190         
Ser Pro Leu Leu Ala Ser Gln Ser Trp Ser Ser Arg Ala Ser Pro Leu
        195                 200                 205             
Ala Phe Asn Ile Ala Asn Ser Ser Ser Glu Ala Asp Cys Pro Asp Pro
    210                 215                 220                 
Phe Ala Asn Gly Ala Asp Val Gln Val Ser Asn Ile Asp Tyr Arg Leu
225                 230                 235                 240 
Ser Arg Lys Glu Leu Gln Gln Leu Leu Gln Glu Ala Phe Ala Arg His
                245                 250                 255     
Gly Lys Val Lys Ser Val Glu Leu Ser Pro His Thr Asp Tyr Gln Leu
            260                 265                 270         
Lys Ala Val Val Gln Met Glu Asn Leu Gln Asp Ala Ile Gly Ala Val
        275                 280                 285             
Asn Ser Leu His Arg Tyr Lys Ile Gly Ser Lys Lys Ile Leu Val Ser
    290                 295                 300                 
Leu Ala Thr Gly Ala Ala Ser Lys Ser Leu Ser Leu Leu Arg Phe Gly
305                 310                 315                 320 
His Lys Leu Asn Val Ser Asp Leu Tyr Lys Leu Thr Asp Thr Val Ala
                325                 330                 335     
Ile Arg Glu Gln Gly Asn Gly Arg Leu Val Cys Leu Leu Pro Ser Ser
            340                 345                 350         
Gln Ala Arg Gln Ser Pro Leu Gly Ser Ser Gln Ser His Asp Gly Ser
        355                 360                 365             
Ser Thr Asn Cys Ser Pro Ile Ile Phe Glu Glu Leu Glu Tyr His Glu
    370                 375                 380                 
Pro Val Cys Arg Gln His Cys Ser Asn Lys Asp Phe Ser Phe Pro Asp
385                 390                 395                 400 
Cys Tyr Ile Ala Glu Phe Gly Asp Leu Glu Val Val Gln Glu Asn Gln
                405                 410                 415     
Gly Gly Val Pro Leu Glu His Phe Ile Thr Cys Val Pro Gly Val Asn
            420                 425                 430         
Ile Ala Thr Ala Gln Asn Gly Ile Lys Val Val Lys Trp Ile His Asn
        435                 440                 445             
Lys Pro Pro Pro Pro Asn Thr Asp Pro Trp Leu Leu Arg Ser Lys Ser
    450                 455                 460                 
Pro Val Gly Asn Pro Gln Leu Ile Gln Phe Ser Arg Glu Val Ile Asp
465                 470                 475                 480 
Leu Leu Lys Ser Gln Pro Ser Cys Val Ile Pro Ile Ser His Phe Ile
                485                 490                 495     
Pro Ser Tyr His His His Phe Ala Lys Gln Cys Arg Val Ser Asp Tyr
            500                 505                 510         
Gly Tyr Ser Lys Leu Ile Glu Leu Leu Glu Ala Val Pro His Val Leu
        515                 520                 525             
Gln Ile Leu Gly Met Gly Ser Lys Arg Leu Leu Thr Leu Thr His Arg
    530                 535                 540                 
Ala Gln Val Lys Arg Phe Thr Gln Asp Leu Leu Lys Leu Leu Lys Ser
545                 550                 555                 560 
Gln Ala Ser Lys Gln Val Ile Val Arg Glu Phe Ser Gln Ala Tyr His
                565                 570                 575     
Trp Cys Phe Ser Lys Asp Trp Asp Val Thr Glu Tyr Gly Val Cys Glu
            580                 585                 590         
Leu Ile Asp Ile Val Ser Glu Ile Pro Asp Thr Thr Ile Cys Leu Ser
        595                 600                 605             
Gln Gln Asp Asn Glu Met Val Ile Cys Ile Pro Lys Arg Glu Arg Thr
    610                 615                 620                 
Gln Asp Glu Ile Glu Arg Thr Lys Gln Phe Ser Lys Asp Val Val Asp
625                 630                 635                 640 
Leu Leu Arg His Gln Pro His Phe Arg Met Pro Phe Asn Lys Phe Ile
                645                 650                 655     
Pro Ser Tyr His His His Phe Gly Arg Gln Cys Lys Leu Ala Tyr Tyr
            660                 665                 670         
Gly Phe Thr Lys Leu Leu Glu Leu Phe Glu Ala Ile Pro Asp Thr Leu
        675                 680                 685             
Gln Val Leu Glu Cys Gly Glu Glu Lys Ile Leu Thr Leu Thr Glu Val
    690                 695                 700                 
Glu Arg Phe Lys Ala Leu Ala Ala Gln Phe Val Lys Leu Leu Arg Ser
705                 710                 715                 720 
Gln Lys Asp Asn Cys Leu Met Met Thr Asp Leu Leu Thr Glu Tyr Ala
                725                 730                 735     
Lys Thr Phe Gly Tyr Thr Phe Arg Leu Gln Asp Tyr Asp Val Ser Ser
            740                 745                 750         
Ile Ser Ala Leu Thr Gln Lys Leu Cys His Val Val Lys Val Ala Asp
        755                 760                 765             
Ile Glu Ser Gly Arg Gln Ile Gln Leu Ile Asn Arg Lys Ser Leu Arg
    770                 775                 780                 
Ser Leu Thr Ala Gln Leu Leu Val Leu Leu Met Ser Trp Glu Gly Thr
785                 790                 795                 800 
Thr His Leu Ser Val Glu Glu Leu Lys Arg His Tyr Glu Ser Thr His
                805                 810                 815     
Asn Thr Pro Leu Asn Pro Cys Glu Tyr Gly Phe Met Thr Leu Thr Glu
            820                 825                 830         
Leu Leu Lys Ser Leu Pro Tyr Leu Val Glu Thr Ala Ala Ala Phe Asp
        835                 840                 845             
Leu Gln Ile Glu Leu Lys Phe Ala Gly Gly Tyr Ser Leu Leu Leu Glu
    850                 855                 860                 
Glu Ile Leu Glu Tyr Ile Pro Pro Pro Phe Leu Ser Pro Leu Pro Ser
865                 870                 875                 880 
Phe Leu Pro Pro Pro Pro Phe Phe Phe Phe Val Phe Phe Val Ile Phe
                885                 890                 895     
Ile Phe Phe Ile Phe Val Phe Val Gln Phe Val Val Phe Val Phe Phe
            900                 905                 910         
Ile Val Val Phe Val Phe Phe Ile Val Val Phe Val Phe Thr Asn Asp
        915                 920                 925             
Lys Met Glu Glu Cys Val Lys Leu Thr Ser Leu Tyr Leu Phe Ala Lys
    930                 935                 940                 
Asn Val Arg Ser Leu Leu His Thr Tyr His Tyr Gln Gln Ile Phe Leu
945                 950                 955                 960 
His Glu Phe Ser Met Ala Tyr Thr Lys Tyr Val Gly Glu Thr Leu Gln
                965                 970                 975     
Pro Lys Thr Tyr Gly His Ser Ser Val Glu Glu Leu Leu Gly Ala Ile
            980                 985                 990         
Pro Gln Val Val Val Gln Phe Leu Gln Lys Asn Gly Lys Glu Leu Ser
        995                 1000                1005            
Cys Glu Asn Tyr Leu Asn Leu Tyr Ala Lys Ala Gly Arg Leu Ser Ser
    1010                1015                1020                
Leu Ser Leu Ser Pro Ala Asn His Glu Asn Gln Pro Ser Glu Gly Glu
1025                1030                1035                1040
Arg Ile Leu Glu Val Pro Glu Ser His Thr Ala Ser Glu Leu Lys Leu
                1045                1050                1055    
Gly Ala Asp Gly Ser Gly Pro Ser His Thr Glu Gln Glu Leu Leu Arg
            1060                1065                1070        
Leu Thr Asp Asp Ser Pro Val Asp Leu Leu Cys Ala Pro Val Pro Ser
        1075                1080                1085            
Cys Leu Pro Ser Pro Gln Leu Arg Pro Asp Pro Val Ile Leu Gln Ser
    1090                1095                1100                
Ala Asp Leu Ile Gln Phe Glu Glu Arg Pro Gln Glu Pro Ser Glu Ile
1105                1110                1115                1120
Met Ile Leu Asn Gln Glu Glu Lys Met Glu Ile Pro Ile Pro Gly Lys
                1125                1130                1135    
Ser Lys Thr Leu Thr Ser Asp Ser Ser Ser Ser Cys Ile Ser Ala Ala
            1140                1145                1150        
Val Pro Val Pro Pro Cys Pro Ser Ser Glu Thr Ser Glu Ser Leu Leu
        1155                1160                1165            
Ser Lys Asp Pro Val Glu Ser Pro Ala Lys Lys Gln Pro Lys Asn Arg
    1170                1175                1180                
Val Lys Leu Ala Ala Asn Phe Ser Leu Ala Pro Ile Thr Lys Leu
1185                1190                1195                


<210> 5748
<211> 1403
<212> PRT
<213> Homo sapiens

<400> 5748
Met Val Ser Ser Gly Cys Arg Met Arg Ser Leu Trp Phe Ile Ile Val
 1               5                  10                  15      
Ile Ser Phe Leu Pro Asn Thr Glu Gly Phe Ser Arg Ala Ala Leu Pro
            20                  25                  30          
Phe Gly Leu Val Arg Arg Glu Leu Ser Cys Glu Gly Tyr Ser Ile Asp
        35                  40                  45              
Leu Arg Cys Pro Gly Ser Asp Val Ile Met Ile Glu Ser Ala Asn Tyr
    50                  55                  60                  
Gly Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu
65                  70                  75                  80  
Asn Thr Asp Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Thr Gln Arg
                85                  90                  95      
Cys Asn Asn Arg Thr Gln Cys Ile Val Val Thr Gly Ser Asp Val Phe
            100                 105                 110         
Pro Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu
        115                 120                 125             
Cys Val Pro Tyr Ile Phe Val Cys Pro Gly Thr Leu Lys Ala Ile Val
    130                 135                 140                 
Asp Ser Pro Cys Ile Tyr Glu Ala Glu Gln Lys Ala Gly Ala Trp Cys
145                 150                 155                 160 
Lys Asp Pro Leu Gln Ala Ala Asp Lys Ile Tyr Phe Met Pro Trp Thr
                165                 170                 175     
Pro Tyr Arg Thr Asp Thr Leu Ile Glu Tyr Ala Ser Leu Glu Asp Phe
            180                 185                 190         
Gln Asn Ser Arg Gln Thr Thr Thr Tyr Lys Leu Pro Asn Arg Val Asp
        195                 200                 205             
Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe Phe Asn Lys Glu
    210                 215                 220                 
Arg Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser
225                 230                 235                 240 
Gly Glu Ala Ile Ile Asn Tyr Ala Asn Tyr His Asp Thr Ser Pro Tyr
                245                 250                 255     
Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val Asp Glu Asn Gly
            260                 265                 270         
Leu Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Met Ile Val Ile
        275                 280                 285             
Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Ala Thr Trp Glu Thr
    290                 295                 300                 
Val Tyr Asp Lys Arg Ala Ala Ser Asn Ala Phe Met Ile Cys Gly Val
305                 310                 315                 320 
Leu Tyr Val Val Arg Ser Val Tyr Gln Asp Asn Glu Ser Glu Thr Gly
                325                 330                 335     
Lys Asn Ser Ile Asp Tyr Ile Tyr Asn Thr Arg Leu Asn Arg Gly Glu
            340                 345                 350         
Tyr Val Asp Val Pro Phe Pro Asn Gln Tyr Gln Tyr Ile Ala Ala Val
        355                 360                 365             
Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp Asn Asn Asn Phe
    370                 375                 380                 
Ile Leu Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp Pro Ala Gln Val
385                 390                 395                 400 
Pro Thr Thr Ala Val Thr Ile Thr Ser Ser Ala Glu Leu Phe Lys Thr
                405                 410                 415     
Ile Ile Ser Thr Thr Ser Thr Thr Ser Gln Lys Gly Pro Met Ser Thr
            420                 425                 430         
Thr Val Ala Gly Ser Gln Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro
        435                 440                 445             
Ala Val Ser Thr Thr Lys Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu
    450                 455                 460                 
Pro Glu Arg Phe Cys Glu Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro
465                 470                 475                 480 
Gln Thr Gln Arg Gly Met Met Val Glu Arg Pro Cys Pro Lys Gly Thr
                485                 490                 495     
Arg Gly Thr Ala Ser Tyr Leu Cys Met Ile Ser Thr Gly Thr Trp Asn
            500                 505                 510         
Pro Lys Gly Pro Asp Leu Ser Asn Cys Thr Ser His Trp Val Asn Gln
        515                 520                 525             
Leu Ala Gln Lys Ile Arg Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn
    530                 535                 540                 
Glu Leu Ala Lys His Thr Lys Gly Pro Val Phe Ala Gly Asp Val Ser
545                 550                 555                 560 
Ser Ser Val Arg Leu Met Glu Gln Leu Val Asp Ile Leu Asp Ala Gln
                565                 570                 575     
Leu Gln Glu Leu Lys Pro Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr
            580                 585                 590         
Asn Lys Ala Ile Val Asp Thr Val Asp Asn Leu Leu Arg Pro Glu Ala
        595                 600                 605             
Leu Glu Ser Trp Lys His Met Asn Ser Ser Glu Gln Ala His Thr Ala
    610                 615                 620                 
Thr Met Leu Leu Asp Thr Leu Glu Glu Gly Ala Phe Val Leu Ala Asp
625                 630                 635                 640 
Asn Leu Leu Glu Pro Thr Arg Val Ser Met Pro Thr Glu Asn Ile Val
                645                 650                 655     
Leu Glu Val Ala Val Leu Ser Thr Glu Gly Gln Ile Gln Asp Phe Lys
            660                 665                 670         
Phe Pro Leu Gly Ile Lys Gly Ala Gly Ser Ser Ile Gln Leu Ser Ala
        675                 680                 685             
Asn Thr Val Lys Gln Asn Ser Arg Asn Gly Leu Ala Lys Leu Val Phe
    690                 695                 700                 
Ile Ile Tyr Arg Ser Leu Gly Gln Phe Leu Ser Thr Glu Asn Ala Thr
705                 710                 715                 720 
Ile Lys Leu Gly Ala Asp Phe Ile Gly Arg Asn Ser Thr Ile Ala Val
                725                 730                 735     
Asn Ser His Val Ile Ser Val Ser Ile Asn Lys Glu Ser Ser Arg Val
            740                 745                 750         
Tyr Leu Thr Asp Pro Val Leu Phe Thr Leu Pro His Ile Asp Pro Asp
        755                 760                 765             
Asn Tyr Phe Asn Ala Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Thr
    770                 775                 780                 
Met Met Gly Tyr Trp Ser Thr Gln Gly Cys Lys Leu Val Asp Thr Asn
785                 790                 795                 800 
Lys Thr Arg Thr Thr Cys Ala Cys Ser His Leu Thr Asn Phe Ala Ile
                805                 810                 815     
Leu Met Ala His Arg Glu Ile Ala Tyr Lys Asp Gly Val His Glu Leu
            820                 825                 830         
Leu Leu Thr Val Ile Thr Trp Val Gly Ile Val Ile Ser Leu Val Cys
        835                 840                 845             
Leu Ala Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser
    850                 855                 860                 
Asp Arg Asn Thr Ile His Lys Asn Leu Cys Ile Asn Leu Phe Ile Ala
865                 870                 875                 880 
Glu Phe Ile Phe Leu Ile Gly Ile Asp Lys Thr Lys Tyr Ala Ile Ala
                885                 890                 895     
Cys Pro Ile Phe Ala Gly Leu Leu His Phe Phe Phe Leu Ala Ala Phe
            900                 905                 910         
Ala Trp Met Cys Leu Glu Gly Val Gln Leu Tyr Leu Met Leu Val Glu
        915                 920                 925             
Val Phe Glu Ser Glu Tyr Ser Arg Lys Lys Tyr Tyr Tyr Val Ala Gly
    930                 935                 940                 
Tyr Leu Phe Pro Ala Thr Val Val Gly Val Ser Ala Ala Ile Asp Tyr
945                 950                 955                 960 
Lys Ser Tyr Gly Thr Glu Lys Ala Cys Trp Leu His Val Asp Asn Tyr
                965                 970                 975     
Phe Ile Trp Ser Phe Ile Gly Pro Val Thr Phe Ile Ile Leu Leu Asn
            980                 985                 990         
Ile Ile Phe Leu Val Ile Thr Leu Cys Lys Met Val Lys His Ser Asn
        995                 1000                1005            
Thr Leu Lys Pro Asp Ser Ser Arg Leu Glu Asn Ile Lys Ser Trp Val
    1010                1015                1020                
Leu Gly Ala Phe Ala Leu Leu Cys Leu Leu Gly Leu Thr Trp Ser Phe
1025                1030                1035                1040
Gly Leu Leu Phe Ile Asn Glu Glu Thr Ile Val Met Ala Tyr Leu Phe
                1045                1050                1055    
Thr Ile Phe Asn Ala Phe Gln Gly Val Phe Ile Phe Ile Phe His Cys
            1060                1065                1070        
Ala Leu Gln Lys Lys Val Arg Lys Glu Tyr Gly Lys Cys Phe Arg His
        1075                1080                1085            
Ser Tyr Cys Cys Gly Gly Leu Pro Thr Glu Ser Pro His Ser Ser Val
    1090                1095                1100                
Lys Ala Ser Thr Thr Arg Thr Ser Ala Arg Tyr Ser Ser Gly Thr Gln
1105                1110                1115                1120
Ser Arg Ile Arg Arg Met Trp Asn Asp Thr Val Arg Lys Gln Ser Glu
                1125                1130                1135    
Ser Ser Phe Ile Ser Gly Asp Ile Asn Ser Thr Ser Thr Leu Asn Gln
            1140                1145                1150        
Gly His Ser Leu Asn Asn Ala Arg Asp Thr Ser Ala Met Asp Thr Leu
        1155                1160                1165            
Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu His Lys Gly Asp
    1170                1175                1180                
Tyr Asn Asp Ser Val Gln Val Val Asp Cys Gly Leu Ser Leu Asn Asp
1185                1190                1195                1200
Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn Asn Leu
                1205                1210                1215    
Arg Gly Ser Ser Lys Thr His Asn Leu Glu Leu Thr Leu Pro Val Lys
            1220                1225                1230        
Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala Ile Val Ala Asp
        1235                1240                1245            
Ala Ser Ser Leu Met His Ser Asp Asn Pro Gly Leu Glu Leu His His
    1250                1255                1260                
Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr His Ser Leu Leu
1265                1270                1275                1280
Tyr Gln Pro Gln Lys Lys Val Lys Ser Glu Gly Thr Asp Ser Tyr Val
                1285                1290                1295    
Ser Gln Leu Thr Ala Glu Ala Glu Asp His Leu Gln Ser Pro Asn Arg
            1300                1305                1310        
Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp Ser Pro Tyr Pro
        1315                1320                1325            
Glu Ser Ser Pro Asp Met Glu Glu Asp Leu Ser Pro Ser Arg Arg Ser
    1330                1335                1340                
Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn Leu Gly Ala Gly
1345                1350                1355                1360
His Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly Asn Ser Asp Gly
                1365                1370                1375    
Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro Glu Gly Asp Val
            1380                1385                1390        
Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu
        1395                1400            


<210> 5749
<211> 1021
<212> PRT
<213> Homo sapiens

<400> 5749
Glu Gly Ser Lys Gly Thr Lys Pro Pro Pro Ala Val Ser Thr Thr Lys
 1               5                  10                  15      
Ile Pro Pro Ile Thr Asn Ile Phe Pro Leu Pro Glu Arg Phe Cys Glu
            20                  25                  30          
Ala Leu Asp Ser Lys Gly Ile Lys Trp Pro Gln Thr Gln Arg Gly Met
        35                  40                  45              
Met Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Thr Ala Ser Tyr
    50                  55                  60                  
Leu Cys Met Ile Ser Thr Gly Thr Trp Asn Pro Lys Gly Pro Asp Leu
65                  70                  75                  80  
Ser Asn Cys Thr Ser His Trp Val Asn Gln Leu Ala Gln Lys Ile Arg
                85                  90                  95      
Ser Gly Glu Asn Ala Ala Ser Leu Ala Asn Glu Leu Ala Lys His Thr
            100                 105                 110         
Lys Gly Pro Val Phe Ala Gly Asp Val Ser Ser Ser Val Arg Leu Met
        115                 120                 125             
Glu Gln Leu Val Asp Ile Leu Asp Ala Gln Leu Gln Glu Leu Lys Pro
    130                 135                 140                 
Ser Glu Lys Asp Ser Ala Gly Arg Ser Tyr Asn Lys Leu Gln Lys Arg
145                 150                 155                 160 
Glu Lys Thr Cys Arg Ala Tyr Leu Lys Ala Ile Val Asp Thr Val Asp
                165                 170                 175     
Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys His Met Asn Ser
            180                 185                 190         
Ser Glu Gln Ala His Thr Ala Thr Met Leu Leu Asp Thr Leu Glu Glu
        195                 200                 205             
Gly Ala Phe Val Leu Ala Asp Asn Leu Leu Glu Pro Thr Arg Val Ser
    210                 215                 220                 
Met Pro Thr Glu Asn Ile Val Leu Glu Val Ala Val Leu Ser Thr Glu
225                 230                 235                 240 
Gly Gln Ile Gln Asp Phe Lys Phe Pro Leu Gly Ile Lys Gly Ala Gly
                245                 250                 255     
Ser Ser Ile Gln Leu Ser Ala Asn Thr Val Lys Gln Asn Ser Arg Asn
            260                 265                 270         
Gly Leu Ala Lys Leu Val Phe Ile Ile Tyr Arg Ser Leu Gly Gln Phe
        275                 280                 285             
Leu Ser Thr Glu Asn Ala Thr Ile Lys Leu Gly Ala Asp Phe Ile Gly
    290                 295                 300                 
Arg Asn Ser Thr Ile Ala Val Asn Ser His Val Ile Ser Val Ser Ile
305                 310                 315                 320 
Asn Lys Glu Ser Ser Arg Val Tyr Leu Thr Asp Pro Val Leu Phe Thr
                325                 330                 335     
Leu Pro His Ile Asp Pro Asp Asn Tyr Phe Asn Ala Asn Cys Ser Phe
            340                 345                 350         
Trp Asn Tyr Ser Glu Arg Thr Met Met Gly Tyr Trp Ser Thr Gln Gly
        355                 360                 365             
Cys Lys Leu Val Asp Thr Asn Lys Thr Arg Thr Thr Cys Ala Cys Ser
    370                 375                 380                 
His Leu Thr Asn Phe Ala Ile Leu Met Ala His Arg Glu Ile Ala Tyr
385                 390                 395                 400 
Lys Asp Gly Val His Glu Leu Leu Leu Thr Val Ile Thr Trp Val Gly
                405                 410                 415     
Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Phe Thr Phe Cys
            420                 425                 430         
Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile His Lys Asn Leu
        435                 440                 445             
Cys Ile Asn Leu Phe Ile Ala Glu Phe Ile Phe Leu Ile Gly Ile Asp
    450                 455                 460                 
Lys Thr Lys Tyr Ala Ile Ala Cys Pro Ile Phe Ala Gly Leu Leu His
465                 470                 475                 480 
Phe Phe Phe Leu Ala Ala Phe Ala Trp Met Cys Leu Glu Gly Val Gln
                485                 490                 495     
Leu Tyr Leu Met Leu Val Glu Val Phe Glu Ser Glu Tyr Ser Arg Lys
            500                 505                 510         
Lys Tyr Tyr Tyr Val Ala Gly Tyr Leu Phe Pro Ala Thr Val Val Gly
        515                 520                 525             
Val Ser Ala Ala Ile Asp Tyr Lys Ser Tyr Gly Thr Glu Lys Ala Cys
    530                 535                 540                 
Trp Leu His Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile Gly Pro Val
545                 550                 555                 560 
Thr Phe Ile Ile Leu Leu Asn Ile Ile Phe Leu Val Ile Thr Leu Cys
                565                 570                 575     
Lys Met Val Lys His Ser Asn Thr Leu Lys Pro Asp Ser Ser Arg Leu
            580                 585                 590         
Glu Asn Ile Lys Ser Trp Val Leu Gly Ala Phe Ala Leu Leu Cys Leu
        595                 600                 605             
Leu Gly Leu Thr Trp Ser Phe Gly Leu Leu Phe Ile Asn Glu Glu Thr
    610                 615                 620                 
Ile Val Met Ala Tyr Leu Phe Thr Ile Phe Asn Ala Phe Gln Gly Val
625                 630                 635                 640 
Phe Ile Phe Ile Phe His Cys Ala Leu Gln Lys Lys Val Arg Lys Glu
                645                 650                 655     
Tyr Gly Lys Cys Phe Arg His Ser Tyr Cys Cys Gly Gly Leu Pro Thr
            660                 665                 670         
Glu Ser Pro His Ser Ser Val Lys Ala Ser Thr Thr Arg Thr Ser Ala
        675                 680                 685             
Arg Tyr Ser Ser Gly Thr Gln Ser Arg Ile Arg Arg Met Trp Asn Asp
    690                 695                 700                 
Thr Val Arg Lys Gln Ser Glu Ser Ser Phe Ile Ser Gly Asp Ile Asn
705                 710                 715                 720 
Ser Thr Ser Thr Leu Asn Gln Gly Met Thr Gly Asn Tyr Leu Leu Thr
                725                 730                 735     
Asn Pro Leu Leu Arg Pro His Gly Thr Asn Asn Pro Tyr Asn Thr Leu
            740                 745                 750         
Leu Ala Glu Thr Val Val Cys Asn Ala Pro Ser Ala Pro Val Phe Asn
        755                 760                 765             
Ser Pro Gly His Ser Leu Asn Asn Ala Arg Asp Thr Ser Ala Met Asp
    770                 775                 780                 
Thr Leu Pro Leu Asn Gly Asn Phe Asn Asn Ser Tyr Ser Leu His Lys
785                 790                 795                 800 
Gly Asp Tyr Asn Asp Ser Val Gln Val Val Asp Cys Gly Leu Ser Leu
                805                 810                 815     
Asn Asp Thr Ala Phe Glu Lys Met Ile Ile Ser Glu Leu Val His Asn
            820                 825                 830         
Asn Leu Arg Gly Ser Ser Lys Thr His Asn Leu Glu Leu Thr Leu Pro
        835                 840                 845             
Val Lys Pro Val Ile Gly Gly Ser Ser Ser Glu Asp Asp Ala Ile Val
    850                 855                 860                 
Ala Asp Ala Ser Ser Leu Met His Ser Asp Asn Pro Gly Leu Glu Leu
865                 870                 875                 880 
His His Lys Glu Leu Glu Ala Pro Leu Ile Pro Gln Arg Thr His Ser
                885                 890                 895     
Leu Leu Tyr Gln Pro Gln Lys Lys Val Lys Ser Glu Gly Thr Asp Ser
            900                 905                 910         
Tyr Val Ser Gln Leu Thr Ala Glu Ala Glu Asp His Leu Gln Ser Pro
        915                 920                 925             
Asn Arg Asp Ser Leu Tyr Thr Ser Met Pro Asn Leu Arg Asp Ser Pro
    930                 935                 940                 
Tyr Pro Glu Ser Ser Pro Asp Met Glu Glu Asp Leu Ser Pro Ser Arg
945                 950                 955                 960 
Arg Ser Glu Asn Glu Asp Ile Tyr Tyr Lys Ser Met Pro Asn Leu Gly
                965                 970                 975     
Ala Gly His Gln Leu Gln Met Cys Tyr Gln Ile Ser Arg Gly Asn Ser
            980                 985                 990         
Asp Gly Tyr Ile Ile Pro Ile Asn Lys Glu Gly Cys Ile Pro Glu Gly
        995                 1000                1005            
Asp Val Arg Glu Gly Gln Met Gln Leu Val Thr Ser Leu
    1010                1015                1020    


<210> 5750
<211> 759
<212> PRT
<213> Homo sapiens

<400> 5750
Met Asp Pro Gly Ala Leu Glu Met Lys Asn Phe Asn Lys Ile Ile Ser
 1               5                  10                  15      
Phe Leu Tyr Ser Thr Val Gly Ala Leu Asn Lys Ile Gly Thr Asp Gly
            20                  25                  30          
Thr Gln Val Ala Met Val Gln Phe Thr Asp Asp Pro Arg Thr Glu Phe
        35                  40                  45              
Lys Leu Asn Ala Tyr Lys Thr Lys Glu Thr Leu Leu Asp Ala Ile Lys
    50                  55                  60                  
His Ile Ser Tyr Lys Gly Gly Asn Thr Lys Thr Gly Lys Ala Ile Lys
65                  70                  75                  80  
Tyr Val Arg Asp Thr Leu Phe Thr Ala Glu Ser Gly Thr Arg Arg Gly
                85                  90                  95      
Ile Pro Lys Val Ile Val Val Ile Thr Asp Gly Arg Ser Gln Asp Asp
            100                 105                 110         
Val Asn Lys Ile Ser Arg Glu Met Gln Leu Asp Gly Tyr Ser Ile Phe
        115                 120                 125             
Ala Ile Gly Val Ala Asp Ala Asp Tyr Ser Glu Leu Val Ser Ile Gly
    130                 135                 140                 
Ser Lys Pro Ser Ala Arg His Val Phe Phe Val Asp Asp Phe Asp Ala
145                 150                 155                 160 
Phe Lys Lys Ile Glu Asp Glu Leu Ile Thr Phe Val Cys Glu Thr Ala
                165                 170                 175     
Ser Ala Thr Cys Pro Val Val His Lys Asp Gly Ile Asp Leu Ala Gly
            180                 185                 190         
Phe Lys Met Met Glu Met Phe Gly Leu Val Glu Lys Asp Phe Ser Ser
        195                 200                 205             
Val Glu Gly Val Ser Met Glu Pro Gly Thr Phe Asn Val Phe Pro Cys
    210                 215                 220                 
Tyr Gln Leu His Lys Asp Ala Leu Val Ser Gln Pro Thr Arg Tyr Leu
225                 230                 235                 240 
His Pro Glu Gly Leu Pro Ser Asp Tyr Thr Ile Ser Phe Leu Phe Arg
                245                 250                 255     
Ile Leu Pro Asp Thr Pro Gln Glu Pro Phe Ala Leu Trp Glu Ile Leu
            260                 265                 270         
Asn Lys Asn Ser Asp Pro Leu Val Gly Val Ile Leu Asp Asn Gly Gly
        275                 280                 285             
Lys Thr Leu Thr Tyr Phe Asn Tyr Asp Gln Ser Gly Asp Phe Gln Thr
    290                 295                 300                 
Leu Thr Phe Glu Gly Pro Glu Ile Arg Lys Ile Phe Tyr Gly Ser Phe
305                 310                 315                 320 
His Lys Leu His Ile Val Val Ser Glu Thr Leu Val Lys Val Val Ile
                325                 330                 335     
Asp Cys Lys Gln Val Gly Glu Lys Ala Met Asn Ala Ser Ala Asn Ile
            340                 345                 350         
Thr Ser Asp Gly Val Glu Val Leu Gly Lys Met Val Arg Ser Arg Gly
        355                 360                 365             
Pro Gly Gly Asn Ser Ala Pro Phe Gln Leu Gln Met Phe Asp Ile Val
    370                 375                 380                 
Cys Ser Thr Ser Trp Ala Asn Thr Asp Lys Cys Cys Glu Leu Pro Gly
385                 390                 395                 400 
Leu Arg Asp Asp Glu Ser Cys Pro Asp Leu Pro His Ser Cys Ser Cys
                405                 410                 415     
Ser Glu Thr Asn Glu Val Ala Leu Gly Pro Ala Gly Pro Pro Gly Gly
            420                 425                 430         
Pro Gly Leu Arg Gly Pro Lys Gly Gln Gln Gly Glu Pro Gly Pro Lys
        435                 440                 445             
Gly Pro Asp Gly Pro Arg Gly Glu Ile Gly Leu Pro Gly Pro Gln Gly
    450                 455                 460                 
Pro Pro Gly Pro Gln Gly Pro Ser Gly Leu Ser Ile Gln Gly Met Pro
465                 470                 475                 480 
Gly Met Pro Gly Glu Lys Gly Glu Lys Gly Asp Thr Gly Leu Pro Gly
                485                 490                 495     
Pro Gln Gly Ile Pro Gly Gly Val Gly Ser Pro Gly Arg Asp Gly Ser
            500                 505                 510         
Pro Gly Gln Arg Gly Leu Pro Gly Lys Asp Gly Ser Ser Gly Pro Pro
        515                 520                 525             
Gly Pro Pro Gly Pro Ile Gly Ile Pro Gly Thr Pro Gly Val Pro Gly
    530                 535                 540                 
Ile Thr Gly Ser Met Gly Pro Gln Gly Ala Leu Gly Pro Pro Gly Val
545                 550                 555                 560 
Pro Gly Ala Lys Gly Glu Arg Gly Glu Arg Gly Asp Leu Gln Ser Gln
                565                 570                 575     
Ala Met Val Arg Ser Val Ala Arg Gln Val Cys Glu Gln Leu Ile Gln
            580                 585                 590         
Ser His Met Ala Arg Tyr Thr Ala Ile Leu Asn Gln Ile Pro Ser His
        595                 600                 605             
Ser Ser Ser Ile Arg Thr Val Gln Gly Pro Pro Gly Glu Pro Gly Arg
    610                 615                 620                 
Pro Gly Ser Pro Gly Ala Pro Gly Glu Gln Gly Pro Pro Gly Thr Pro
625                 630                 635                 640 
Gly Phe Pro Gly Asn Ala Gly Val Pro Gly Thr Pro Gly Glu Arg Gly
                645                 650                 655     
Leu Thr Gly Ile Lys Gly Glu Lys Gly Asn Pro Gly Val Gly Thr Gln
            660                 665                 670         
Gly Pro Arg Gly Pro Pro Gly Pro Ala Gly Pro Ser Gly Glu Ser Arg
        675                 680                 685             
Pro Gly Ser Pro Gly Pro Pro Gly Ser Pro Gly Pro Arg Gly Pro Pro
    690                 695                 700                 
Gly His Leu Gly Val Pro Gly Pro Gln Gly Pro Ser Gly Gln Pro Gly
705                 710                 715                 720 
Tyr Cys Asp Pro Ser Ser Cys Ser Ala Tyr Gly Val Arg Ala Pro His
                725                 730                 735     
Pro Asp Gln Pro Glu Phe Thr Pro Val Gln Asp Glu Leu Glu Ala Met
            740                 745                 750         
Glu Leu Trp Gly Pro Gly Val
        755                 


<210> 5751
<211> 220
<212> PRT
<213> Homo sapiens

<400> 5751
Met Ala Gly Leu Ser Arg Gly Ser Ala Arg Ala Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Ala Ser Thr Leu Leu Ala Leu Leu Val Ser Pro Ala Arg Gly Arg
            20                  25                  30          
Gly Gly Arg Asp His Gly Asp Trp Asp Glu Ala Ser Arg Leu Pro Pro
        35                  40                  45              
Leu Pro Pro Arg Glu Asp Ala Ala Arg Val Ala Arg Phe Val Thr His
    50                  55                  60                  
Val Ser Asp Trp Gly Ala Leu Ala Thr Ile Ser Thr Leu Glu Ala Val
65                  70                  75                  80  
Arg Gly Arg Pro Phe Ala Asp Val Leu Ser Leu Ser Asp Gly Pro Pro
                85                  90                  95      
Gly Ala Gly Ser Gly Val Pro Tyr Phe Tyr Leu Ser Pro Leu Gln Leu
            100                 105                 110         
Ser Val Ser Asn Leu Gln Glu Asn Pro Tyr Ala Thr Leu Thr Met Thr
        115                 120                 125             
Leu Ala Gln Thr Asn Phe Cys Lys Lys His Gly Phe Asp Pro Gln Ser
    130                 135                 140                 
Pro Leu Cys Val His Ile Met Leu Ser Gly Thr Val Thr Lys Val Asn
145                 150                 155                 160 
Glu Thr Glu Met Asp Ile Ala Lys His Ser Leu Phe Ile Arg His Pro
                165                 170                 175     
Glu Met Lys Thr Trp Pro Ser Ser His Asn Trp Phe Phe Ala Lys Leu
            180                 185                 190         
Asn Ile Thr Asn Ile Trp Val Leu Asp Tyr Phe Gly Gly Pro Lys Ile
        195                 200                 205             
Val Thr Pro Glu Glu Tyr Tyr Asn Val Thr Val Gln
    210                 215                 220 


<210> 5752
<211> 1306
<212> PRT
<213> Homo sapiens

<400> 5752
Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu
 1               5                  10                  15      
Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro
            20                  25                  30          
Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu
        35                  40                  45              
Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser
    50                  55                  60                  
Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala
65                  70                  75                  80  
Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala
                85                  90                  95      
Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe
            100                 105                 110         
Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly
        115                 120                 125             
Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu
    130                 135                 140                 
Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn
145                 150                 155                 160 
Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu
                165                 170                 175     
Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp
            180                 185                 190         
His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr
        195                 200                 205             
Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly
    210                 215                 220                 
Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu
225                 230                 235                 240 
Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala
                245                 250                 255     
Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn
            260                 265                 270         
Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln
        275                 280                 285             
Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro
    290                 295                 300                 
Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr
305                 310                 315                 320 
His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser
                325                 330                 335     
Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala
            340                 345                 350         
Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn
        355                 360                 365             
Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln
    370                 375                 380                 
Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln
385                 390                 395                 400 
Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe
                405                 410                 415     
His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu
            420                 425                 430         
His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu
        435                 440                 445             
Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe
    450                 455                 460                 
Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser
465                 470                 475                 480 
Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg
                485                 490                 495     
Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His
            500                 505                 510         
Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile
        515                 520                 525             
Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu
    530                 535                 540                 
Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr
545                 550                 555                 560 
Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly
                565                 570                 575     
Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp
            580                 585                 590         
Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln
        595                 600                 605             
Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro
    610                 615                 620                 
Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile
625                 630                 635                 640 
Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr
                645                 650                 655     
Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp
            660                 665                 670         
Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln
        675                 680                 685             
Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala
    690                 695                 700                 
Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile
705                 710                 715                 720 
Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu
                725                 730                 735     
Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser
            740                 745                 750         
Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro
        755                 760                 765             
Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu
    770                 775                 780                 
Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln
785                 790                 795                 800 
Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn
                805                 810                 815     
Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro
            820                 825                 830         
Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu
        835                 840                 845             
Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr
    850                 855                 860                 
Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu
865                 870                 875                 880 
Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val
                885                 890                 895     
Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys
            900                 905                 910         
Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe
        915                 920                 925             
Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser
    930                 935                 940                 
Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser
945                 950                 955                 960 
Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr
                965                 970                 975     
Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His
            980                 985                 990         
Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala Leu Arg Glu
        995                 1000                1005            
Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu Ala Leu
    1010                1015                1020                
Ser Val Ser Thr Pro Lys His Leu His Ser Leu Asn Leu Leu Ser Ser
1025                1030                1035                1040
Glu Gly Gly Ser Asp Glu His Asp Ile Asn Phe Leu Met Lys Met Ala
                1045                1050                1055    
Leu Asp Lys Ile Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp Gln Trp
            1060                1065                1070        
Arg Trp Arg Val Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr Asn Gln
        1075                1080                1085            
Glu Trp Trp Ser Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro Pro Val
    1090                1095                1100                
Pro Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His Ile Pro
1105                1110                1115                1120
Ser Ser Val Pro Tyr Ile Arg Tyr Phe Val Ser Phe Ile Ile Gln Phe
                1125                1130                1135    
Gln Phe His Glu Ala Leu Cys Gln Ala Ala Gly His Thr Gly Pro Leu
            1140                1145                1150        
His Lys Cys Asp Ile Tyr Gln Ser Lys Glu Ala Gly Gln Arg Leu Ala
        1155                1160                1165            
Thr Ala Met Lys Leu Gly Phe Ser Arg Pro Trp Pro Glu Ala Met Gln
    1170                1175                1180                
Leu Ile Thr Gly Gln Pro Asn Met Ser Ala Ser Ala Met Leu Ser Tyr
1185                1190                1195                1200
Phe Lys Pro Leu Leu Asp Trp Leu Arg Thr Glu Asn Glu Leu His Gly
                1205                1210                1215    
Glu Lys Leu Gly Trp Pro Gln Tyr Asn Trp Thr Pro Asn Ser Ala Arg
            1220                1225                1230        
Ser Glu Gly Pro Leu Pro Asp Ser Gly Arg Val Ser Phe Leu Gly Leu
        1235                1240                1245            
Asp Leu Asp Ala Gln Gln Ala Arg Val Gly Gln Trp Leu Leu Leu Phe
    1250                1255                1260                
Leu Gly Ile Ala Leu Leu Val Ala Thr Leu Gly Leu Ser Gln Arg Leu
1265                1270                1275                1280
Phe Ser Ile Arg His Arg Ser Leu His Arg His Ser His Gly Pro Gln
                1285                1290                1295    
Phe Gly Ser Glu Val Glu Leu Arg His Ser
            1300                1305    


<210> 5753
<211> 4544
<212> PRT
<213> Homo sapiens

<400> 5753
Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu
 1               5                  10                  15      
Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe
            20                  25                  30          
Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp
        35                  40                  45              
Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys
    50                  55                  60                  
Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu
65                  70                  75                  80  
Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln
                85                  90                  95      
Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln
            100                 105                 110         
Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu
        115                 120                 125             
Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp
    130                 135                 140                 
Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys
145                 150                 155                 160 
Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val
                165                 170                 175     
Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn
            180                 185                 190         
Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn
        195                 200                 205             
Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro
    210                 215                 220                 
Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu
225                 230                 235                 240 
Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu
                245                 250                 255     
Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr
            260                 265                 270         
Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp
        275                 280                 285             
Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile
    290                 295                 300                 
Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu
305                 310                 315                 320 
Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys
                325                 330                 335     
Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp
            340                 345                 350         
Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe
        355                 360                 365             
Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala
    370                 375                 380                 
Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly
385                 390                 395                 400 
Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu
                405                 410                 415     
Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn
            420                 425                 430         
Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr
        435                 440                 445             
Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile
    450                 455                 460                 
Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn
465                 470                 475                 480 
Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala
                485                 490                 495     
Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu
            500                 505                 510         
Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu
        515                 520                 525             
Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly
    530                 535                 540                 
Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn
545                 550                 555                 560 
Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala
                565                 570                 575     
Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu
            580                 585                 590         
Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala
        595                 600                 605             
Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys
    610                 615                 620                 
Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys
625                 630                 635                 640 
Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp
                645                 650                 655     
Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys
            660                 665                 670         
Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His
        675                 680                 685             
Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu
    690                 695                 700                 
Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr
705                 710                 715                 720 
Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val
                725                 730                 735     
Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly
            740                 745                 750         
Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu
        755                 760                 765             
Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser
    770                 775                 780                 
Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln
785                 790                 795                 800 
Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser
                805                 810                 815     
Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp
            820                 825                 830         
Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr
        835                 840                 845             
Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser
    850                 855                 860                 
Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu
865                 870                 875                 880 
Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro
                885                 890                 895     
Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp
            900                 905                 910         
Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn
        915                 920                 925             
Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala
    930                 935                 940                 
Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp
945                 950                 955                 960 
Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys
                965                 970                 975     
Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile
            980                 985                 990         
Asn Trp Arg Cys Asp Asn Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu
        995                 1000                1005            
Ala Gly Cys Ser His Ser Cys Ser Ser Thr Gln Phe Lys Cys Asn Ser
    1010                1015                1020                
Gly Arg Cys Ile Pro Glu His Trp Thr Cys Asp Gly Asp Asn Asp Cys
1025                1030                1035                1040
Gly Asp Tyr Ser Asp Glu Thr His Ala Asn Cys Thr Asn Gln Ala Thr
                1045                1050                1055    
Arg Pro Pro Gly Gly Cys His Thr Asp Glu Phe Gln Cys Arg Leu Asp
            1060                1065                1070        
Gly Leu Cys Ile Pro Leu Arg Trp Arg Cys Asp Gly Asp Thr Asp Cys
        1075                1080                1085            
Met Asp Ser Ser Asp Glu Lys Ser Cys Glu Gly Val Thr His Val Cys
    1090                1095                1100                
Asp Pro Ser Val Lys Phe Gly Cys Lys Asp Ser Ala Arg Cys Ile Ser
1105                1110                1115                1120
Lys Ala Trp Val Cys Asp Gly Asp Asn Asp Cys Glu Asp Asn Ser Asp
                1125                1130                1135    
Glu Glu Asn Cys Glu Ser Leu Ala Cys Arg Pro Pro Ser His Pro Cys
            1140                1145                1150        
Ala Asn Asn Thr Ser Val Cys Leu Pro Pro Asp Lys Leu Cys Asp Gly
        1155                1160                1165            
Asn Asp Asp Cys Gly Asp Gly Ser Asp Glu Gly Glu Leu Cys Asp Gln
    1170                1175                1180                
Cys Ser Leu Asn Asn Gly Gly Cys Ser His Asn Cys Ser Val Ala Pro
1185                1190                1195                1200
Gly Glu Gly Ile Val Cys Ser Cys Pro Leu Gly Met Glu Leu Gly Pro
                1205                1210                1215    
Asp Asn His Thr Cys Gln Ile Gln Ser Tyr Cys Ala Lys His Leu Lys
            1220                1225                1230        
Cys Ser Gln Lys Cys Asp Gln Asn Lys Phe Ser Val Lys Cys Ser Cys
        1235                1240                1245            
Tyr Glu Gly Trp Val Leu Glu Pro Asp Gly Glu Ser Cys Arg Ser Leu
    1250                1255                1260                
Asp Pro Phe Lys Pro Phe Ile Ile Phe Ser Asn Arg His Glu Ile Arg
1265                1270                1275                1280
Arg Ile Asp Leu His Lys Gly Asp Tyr Ser Val Leu Val Pro Gly Leu
                1285                1290                1295    
Arg Asn Thr Ile Ala Leu Asp Phe His Leu Ser Gln Ser Ala Leu Tyr
            1300                1305                1310        
Trp Thr Asp Val Val Glu Asp Lys Ile Tyr Arg Gly Lys Leu Leu Asp
        1315                1320                1325            
Asn Gly Ala Leu Thr Ser Phe Glu Val Val Ile Gln Tyr Gly Leu Ala
    1330                1335                1340                
Thr Pro Glu Gly Leu Ala Val Asp Trp Ile Ala Gly Asn Ile Tyr Trp
1345                1350                1355                1360
Val Glu Ser Asn Leu Asp Gln Ile Glu Val Ala Lys Leu Asp Gly Thr
                1365                1370                1375    
Leu Arg Thr Thr Leu Leu Ala Gly Asp Ile Glu His Pro Arg Ala Ile
            1380                1385                1390        
Ala Leu Asp Pro Arg Asp Gly Ile Leu Phe Trp Thr Asp Trp Asp Ala
        1395                1400                1405            
Ser Leu Pro Arg Ile Glu Ala Ala Ser Met Ser Gly Ala Gly Arg Arg
    1410                1415                1420                
Thr Val His Arg Glu Thr Gly Ser Gly Gly Trp Pro Asn Gly Leu Thr
1425                1430                1435                1440
Val Asp Tyr Leu Glu Lys Arg Ile Leu Trp Ile Asp Ala Arg Ser Asp
                1445                1450                1455    
Ala Ile Tyr Ser Ala Arg Tyr Asp Gly Ser Gly His Met Glu Val Leu
            1460                1465                1470        
Arg Gly His Glu Phe Leu Ser His Pro Phe Ala Val Thr Leu Tyr Gly
        1475                1480                1485            
Gly Glu Val Tyr Trp Thr Asp Trp Arg Thr Asn Thr Leu Ala Lys Ala
    1490                1495                1500                
Asn Lys Trp Thr Gly His Asn Val Thr Val Val Gln Arg Thr Asn Thr
1505                1510                1515                1520
Gln Pro Phe Asp Leu Gln Val Tyr His Pro Ser Arg Gln Pro Met Ala
                1525                1530                1535    
Pro Asn Pro Cys Glu Ala Asn Gly Gly Gln Gly Pro Cys Ser His Leu
            1540                1545                1550        
Cys Leu Ile Asn Tyr Asn Arg Thr Val Ser Cys Ala Cys Pro His Leu
        1555                1560                1565            
Met Lys Leu His Lys Asp Asn Thr Thr Cys Tyr Glu Phe Lys Lys Phe
    1570                1575                1580                
Leu Leu Tyr Ala Arg Gln Met Glu Ile Arg Gly Val Asp Leu Asp Ala
1585                1590                1595                1600
Pro Tyr Tyr Asn Tyr Ile Ile Ser Phe Thr Val Pro Asp Ile Asp Asn
                1605                1610                1615    
Val Thr Val Leu Asp Tyr Asp Ala Arg Glu Gln Arg Val Tyr Trp Ser
            1620                1625                1630        
Asp Val Arg Thr Gln Ala Ile Lys Arg Ala Phe Ile Asn Gly Thr Gly
        1635                1640                1645            
Val Glu Thr Val Val Ser Ala Asp Leu Pro Asn Ala His Gly Leu Ala
    1650                1655                1660                
Val Asp Trp Val Ser Arg Asn Leu Phe Trp Thr Ser Tyr Asp Thr Asn
1665                1670                1675                1680
Lys Lys Gln Ile Asn Val Ala Arg Leu Asp Gly Ser Phe Lys Asn Ala
                1685                1690                1695    
Val Val Gln Gly Leu Glu Gln Pro His Gly Leu Val Val His Pro Leu
            1700                1705                1710        
Arg Gly Lys Leu Tyr Trp Thr Asp Gly Asp Asn Ile Ser Met Ala Asn
        1715                1720                1725            
Met Asp Gly Ser Asn Arg Thr Leu Leu Phe Ser Gly Gln Lys Gly Pro
    1730                1735                1740                
Val Gly Leu Ala Ile Asp Phe Pro Glu Ser Lys Leu Tyr Trp Ile Ser
1745                1750                1755                1760
Ser Gly Asn His Thr Ile Asn Arg Cys Asn Leu Asp Gly Ser Gly Leu
                1765                1770                1775    
Glu Val Ile Asp Ala Met Arg Ser Gln Leu Gly Lys Ala Thr Ala Leu
            1780                1785                1790        
Ala Ile Met Gly Asp Lys Leu Trp Trp Ala Asp Gln Val Ser Glu Lys
        1795                1800                1805            
Met Gly Thr Cys Ser Lys Ala Asp Gly Ser Gly Ser Val Val Leu Arg
    1810                1815                1820                
Asn Ser Thr Thr Leu Val Met His Met Lys Val Tyr Asp Glu Ser Ile
1825                1830                1835                1840
Gln Leu Asp His Lys Gly Thr Asn Pro Cys Ser Val Asn Asn Gly Asp
                1845                1850                1855    
Cys Ser Gln Leu Cys Leu Pro Thr Ser Glu Thr Thr Arg Ser Cys Met
            1860                1865                1870        
Cys Thr Ala Gly Tyr Ser Leu Arg Ser Gly Gln Gln Ala Cys Glu Gly
        1875                1880                1885            
Val Gly Ser Phe Leu Leu Tyr Ser Val His Glu Gly Ile Arg Gly Ile
    1890                1895                1900                
Pro Leu Asp Pro Asn Asp Lys Ser Asp Ala Leu Val Pro Val Ser Gly
1905                1910                1915                1920
Thr Ser Leu Ala Val Gly Ile Asp Phe His Ala Glu Asn Asp Thr Ile
                1925                1930                1935    
Tyr Trp Val Asp Met Gly Leu Ser Thr Ile Ser Arg Ala Lys Arg Asp
            1940                1945                1950        
Gln Thr Trp Arg Glu Asp Val Val Thr Asn Gly Ile Gly Arg Val Glu
        1955                1960                1965            
Gly Ile Ala Val Asp Trp Ile Ala Gly Asn Ile Tyr Trp Thr Asp Gln
    1970                1975                1980                
Gly Phe Asp Val Ile Glu Val Ala Arg Leu Asn Gly Ser Phe Arg Tyr
1985                1990                1995                2000
Val Val Ile Ser Gln Gly Leu Asp Lys Pro Arg Ala Ile Thr Val His
                2005                2010                2015    
Pro Glu Lys Gly Tyr Leu Phe Trp Thr Glu Trp Gly Gln Tyr Pro Arg
            2020                2025                2030        
Ile Glu Arg Ser Arg Leu Asp Gly Thr Glu Arg Val Val Leu Val Asn
        2035                2040                2045            
Val Ser Ile Ser Trp Pro Asn Gly Ile Ser Val Asp Tyr Gln Asp Gly
    2050                2055                2060                
Lys Leu Tyr Trp Cys Asp Ala Arg Thr Asp Lys Ile Glu Arg Ile Asp
2065                2070                2075                2080
Leu Glu Thr Gly Glu Asn Arg Glu Val Val Leu Ser Ser Asn Asn Met
                2085                2090                2095    
Asp Met Phe Ser Val Ser Val Phe Glu Asp Phe Ile Tyr Trp Ser Asp
            2100                2105                2110        
Arg Thr His Ala Asn Gly Ser Ile Lys Arg Gly Ser Lys Asp Asn Ala
        2115                2120                2125            
Thr Asp Ser Val Pro Leu Arg Thr Gly Ile Gly Val Gln Leu Lys Asp
    2130                2135                2140                
Ile Lys Val Phe Asn Arg Asp Arg Gln Lys Gly Thr Asn Val Cys Ala
2145                2150                2155                2160
Val Ala Asn Gly Gly Cys Gln Gln Leu Cys Leu Tyr Arg Gly Arg Gly
                2165                2170                2175    
Gln Arg Ala Cys Ala Cys Ala His Gly Met Leu Ala Glu Asp Gly Ala
            2180                2185                2190        
Ser Cys Arg Glu Tyr Ala Gly Tyr Leu Leu Tyr Ser Glu Arg Thr Ile
        2195                2200                2205            
Leu Lys Ser Ile His Leu Ser Asp Glu Arg Asn Leu Asn Ala Pro Val
    2210                2215                2220                
Gln Pro Phe Glu Asp Pro Glu His Met Lys Asn Val Ile Ala Leu Ala
2225                2230                2235                2240
Phe Asp Tyr Arg Ala Gly Thr Ser Pro Gly Thr Pro Asn Arg Ile Phe
                2245                2250                2255    
Phe Ser Asp Ile His Phe Gly Asn Ile Gln Gln Ile Asn Asp Asp Gly
            2260                2265                2270        
Ser Arg Arg Ile Thr Ile Val Glu Asn Val Gly Ser Val Glu Gly Leu
        2275                2280                2285            
Ala Tyr His Arg Gly Trp Asp Thr Leu Tyr Trp Thr Ser Tyr Thr Thr
    2290                2295                2300                
Ser Thr Ile Thr Arg His Thr Val Asp Gln Thr Arg Pro Gly Ala Phe
2305                2310                2315                2320
Glu Arg Glu Thr Val Ile Thr Met Ser Gly Asp Asp His Pro Arg Ala
                2325                2330                2335    
Phe Val Leu Asp Glu Cys Gln Asn Leu Met Phe Trp Thr Asn Trp Asn
            2340                2345                2350        
Glu Gln His Pro Ser Ile Met Arg Ala Ala Leu Ser Gly Ala Asn Val
        2355                2360                2365            
Leu Thr Leu Ile Glu Lys Asp Ile Arg Thr Pro Asn Gly Leu Ala Ile
    2370                2375                2380                
Asp His Arg Ala Glu Lys Leu Tyr Phe Ser Asp Ala Thr Leu Asp Lys
2385                2390                2395                2400
Ile Glu Arg Cys Glu Tyr Asp Gly Ser His Arg Tyr Val Ile Leu Lys
                2405                2410                2415    
Ser Glu Pro Val His Pro Phe Gly Leu Ala Val Tyr Gly Glu His Ile
            2420                2425                2430        
Phe Trp Thr Asp Trp Val Arg Arg Ala Val Gln Arg Ala Asn Lys His
        2435                2440                2445            
Val Gly Ser Asn Met Lys Leu Leu Arg Val Asp Ile Pro Gln Gln Pro
    2450                2455                2460                
Met Gly Ile Ile Ala Val Ala Asn Asp Thr Asn Ser Cys Glu Leu Ser
2465                2470                2475                2480
Pro Cys Arg Ile Asn Asn Gly Gly Cys Gln Asp Leu Cys Leu Leu Thr
                2485                2490                2495    
His Gln Gly His Val Asn Cys Ser Cys Arg Gly Gly Arg Ile Leu Gln
            2500                2505                2510        
Asp Asp Leu Thr Cys Arg Ala Val Asn Ser Ser Cys Arg Ala Gln Asp
        2515                2520                2525            
Glu Phe Glu Cys Ala Asn Gly Glu Cys Ile Asn Phe Ser Leu Thr Cys
    2530                2535                2540                
Asp Gly Val Pro His Cys Lys Asp Lys Ser Asp Glu Lys Pro Ser Tyr
2545                2550                2555                2560
Cys Asn Ser Arg Arg Cys Lys Lys Thr Phe Arg Gln Cys Ser Asn Gly
                2565                2570                2575    
Arg Cys Val Ser Asn Met Leu Trp Cys Asn Gly Ala Asp Asp Cys Gly
            2580                2585                2590        
Asp Gly Ser Asp Glu Ile Pro Cys Asn Lys Thr Ala Cys Gly Val Gly
        2595                2600                2605            
Glu Phe Arg Cys Arg Asp Gly Thr Cys Ile Gly Asn Ser Ser Arg Cys
    2610                2615                2620                
Asn Gln Phe Val Asp Cys Glu Asp Ala Ser Asp Glu Met Asn Cys Ser
2625                2630                2635                2640
Ala Thr Asp Cys Ser Ser Tyr Phe Arg Leu Gly Val Lys Gly Val Leu
                2645                2650                2655    
Phe Gln Pro Cys Glu Arg Thr Ser Leu Cys Tyr Ala Pro Ser Trp Val
            2660                2665                2670        
Cys Asp Gly Ala Asn Asp Cys Gly Asp Tyr Ser Asp Glu Arg Asp Cys
        2675                2680                2685            
Pro Gly Val Lys Arg Pro Arg Cys Pro Leu Asn Tyr Phe Ala Cys Pro
    2690                2695                2700                
Ser Gly Arg Cys Ile Pro Met Ser Trp Thr Cys Asp Lys Glu Asp Asp
2705                2710                2715                2720
Cys Glu His Gly Glu Asp Glu Thr His Cys Asn Lys Phe Cys Ser Glu
                2725                2730                2735    
Ala Gln Phe Glu Cys Gln Asn His Arg Cys Ile Ser Lys Gln Trp Leu
            2740                2745                2750        
Cys Asp Gly Ser Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ala His
        2755                2760                2765            
Cys Glu Gly Lys Thr Cys Gly Pro Ser Ser Phe Ser Cys Pro Gly Thr
    2770                2775                2780                
His Val Cys Val Pro Glu Arg Trp Leu Cys Asp Gly Asp Lys Asp Cys
2785                2790                2795                2800
Ala Asp Gly Ala Asp Glu Ser Ile Ala Ala Gly Cys Leu Tyr Asn Ser
                2805                2810                2815    
Thr Cys Asp Asp Arg Glu Phe Met Cys Gln Asn Arg Gln Cys Ile Pro
            2820                2825                2830        
Lys His Phe Val Cys Asp His Asp Arg Asp Cys Ala Asp Gly Ser Asp
        2835                2840                2845            
Glu Ser Pro Glu Cys Glu Tyr Pro Thr Cys Gly Pro Ser Glu Phe Arg
    2850                2855                2860                
Cys Ala Asn Gly Arg Cys Leu Ser Ser Arg Gln Trp Glu Cys Asp Gly
2865                2870                2875                2880
Glu Asn Asp Cys His Asp Gln Ser Asp Glu Ala Pro Lys Asn Pro His
                2885                2890                2895    
Cys Thr Ser Pro Glu His Lys Cys Asn Ala Ser Ser Gln Phe Leu Cys
            2900                2905                2910        
Ser Ser Gly Arg Cys Val Ala Glu Ala Leu Leu Cys Asn Gly Gln Asp
        2915                2920                2925            
Asp Cys Gly Asp Ser Ser Asp Glu Arg Gly Cys His Ile Asn Glu Cys
    2930                2935                2940                
Leu Ser Arg Lys Leu Ser Gly Cys Ser Gln Asp Cys Glu Asp Leu Lys
2945                2950                2955                2960
Ile Gly Phe Lys Cys Arg Cys Arg Pro Gly Phe Arg Leu Lys Asp Asp
                2965                2970                2975    
Gly Arg Thr Cys Ala Asp Val Asp Glu Cys Ser Thr Thr Phe Pro Cys
            2980                2985                2990        
Ser Gln Arg Cys Ile Asn Thr His Gly Ser Tyr Lys Cys Leu Cys Val
        2995                3000                3005            
Glu Gly Tyr Ala Pro Arg Gly Gly Asp Pro His Ser Cys Lys Ala Val
    3010                3015                3020                
Thr Asp Glu Glu Pro Phe Leu Ile Phe Ala Asn Arg Tyr Tyr Leu Arg
3025                3030                3035                3040
Lys Leu Asn Leu Asp Gly Ser Asn Tyr Thr Leu Leu Lys Gln Gly Leu
                3045                3050                3055    
Asn Asn Ala Val Ala Leu Asp Phe Asp Tyr Arg Glu Gln Met Ile Tyr
            3060                3065                3070        
Trp Thr Asp Val Thr Thr Gln Gly Ser Met Ile Arg Arg Met His Leu
        3075                3080                3085            
Asn Gly Ser Asn Val Gln Val Leu His Arg Thr Gly Leu Ser Asn Pro
    3090                3095                3100                
Asp Gly Leu Ala Val Asp Trp Val Gly Gly Asn Leu Tyr Trp Cys Asp
3105                3110                3115                3120
Lys Gly Arg Asp Thr Ile Glu Val Ser Lys Leu Asn Gly Ala Tyr Arg
                3125                3130                3135    
Thr Val Leu Val Ser Ser Gly Leu Arg Glu Pro Arg Ala Leu Val Val
            3140                3145                3150        
Asp Val Gln Asn Gly Tyr Leu Tyr Trp Thr Asp Trp Gly Asp His Ser
        3155                3160                3165            
Leu Ile Gly Arg Ile Gly Met Asp Gly Ser Ser Arg Ser Val Ile Val
    3170                3175                3180                
Asp Thr Lys Ile Thr Trp Pro Asn Gly Leu Thr Leu Asp Tyr Val Thr
3185                3190                3195                3200
Glu Arg Ile Tyr Trp Ala Asp Ala Arg Glu Asp Tyr Ile Glu Phe Ala
                3205                3210                3215    
Ser Leu Asp Gly Ser Asn Arg His Val Val Leu Ser Gln Asp Ile Pro
            3220                3225                3230        
His Ile Phe Ala Leu Thr Leu Phe Glu Asp Tyr Val Tyr Trp Thr Asp
        3235                3240                3245            
Trp Glu Thr Lys Ser Ile Asn Arg Ala His Lys Thr Thr Gly Thr Asn
    3250                3255                3260                
Lys Thr Leu Leu Ile Ser Thr Leu His Arg Pro Met Asp Leu His Val
3265                3270                3275                3280
Phe His Ala Leu Arg Gln Pro Asp Val Pro Asn His Pro Cys Lys Val
                3285                3290                3295    
Asn Asn Gly Gly Cys Ser Asn Leu Cys Leu Leu Ser Pro Gly Gly Gly
            3300                3305                3310        
His Lys Cys Ala Cys Pro Thr Asn Phe Tyr Leu Gly Ser Asp Gly Arg
        3315                3320                3325            
Thr Cys Val Ser Asn Cys Thr Ala Ser Gln Phe Val Cys Lys Asn Asp
    3330                3335                3340                
Lys Cys Ile Pro Phe Trp Trp Lys Cys Asp Thr Glu Asp Asp Cys Gly
3345                3350                3355                3360
Asp His Ser Asp Glu Pro Pro Asp Cys Pro Glu Phe Lys Cys Arg Pro
                3365                3370                3375    
Gly Gln Phe Gln Cys Ser Thr Gly Ile Cys Thr Asn Pro Ala Phe Ile
            3380                3385                3390        
Cys Asp Gly Asp Asn Asp Cys Gln Asp Asn Ser Asp Glu Ala Asn Cys
        3395                3400                3405            
Asp Ile His Val Cys Leu Pro Ser Gln Phe Lys Cys Thr Asn Thr Asn
    3410                3415                3420                
Arg Cys Ile Pro Gly Ile Phe Arg Cys Asn Gly Gln Asp Asn Cys Gly
3425                3430                3435                3440
Asp Gly Glu Asp Glu Arg Asp Cys Pro Glu Val Thr Cys Ala Pro Asn
                3445                3450                3455    
Gln Phe Gln Cys Ser Ile Thr Lys Arg Cys Ile Pro Arg Val Trp Val
            3460                3465                3470        
Cys Asp Arg Asp Asn Asp Cys Val Asp Gly Ser Asp Glu Pro Ala Asn
        3475                3480                3485            
Cys Thr Gln Met Thr Cys Gly Val Asp Glu Phe Arg Cys Lys Asp Ser
    3490                3495                3500                
Gly Arg Cys Ile Pro Ala Arg Trp Lys Cys Asp Gly Glu Asp Asp Cys
3505                3510                3515                3520
Gly Asp Gly Ser Asp Glu Pro Lys Glu Glu Cys Asp Glu Arg Thr Cys
                3525                3530                3535    
Glu Pro Tyr Gln Phe Arg Cys Lys Asn Asn Arg Cys Val Pro Gly Arg
            3540                3545                3550        
Trp Gln Cys Asp Tyr Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Glu
        3555                3560                3565            
Ser Cys Thr Pro Arg Pro Cys Ser Glu Ser Glu Phe Ser Cys Ala Asn
    3570                3575                3580                
Gly Arg Cys Ile Ala Gly Arg Trp Lys Cys Asp Gly Asp His Asp Cys
3585                3590                3595                3600
Ala Asp Gly Ser Asp Glu Lys Asp Cys Thr Pro Arg Cys Asp Met Asp
                3605                3610                3615    
Gln Phe Gln Cys Lys Ser Gly His Cys Ile Pro Leu Arg Trp Arg Cys
            3620                3625                3630        
Asp Ala Asp Ala Asp Cys Met Asp Gly Ser Asp Glu Glu Ala Cys Gly
        3635                3640                3645            
Thr Gly Val Arg Thr Cys Pro Leu Asp Glu Phe Gln Cys Asn Asn Thr
    3650                3655                3660                
Leu Cys Lys Pro Leu Ala Trp Lys Cys Asp Gly Glu Asp Asp Cys Gly
3665                3670                3675                3680
Asp Asn Ser Asp Glu Asn Pro Glu Glu Cys Ala Arg Phe Val Cys Pro
                3685                3690                3695    
Pro Asn Arg Pro Phe Arg Cys Lys Asn Asp Arg Val Cys Leu Trp Ile
            3700                3705                3710        
Gly Arg Gln Cys Asp Gly Thr Asp Asn Cys Gly Asp Gly Thr Asp Glu
        3715                3720                3725            
Glu Asp Cys Glu Pro Pro Thr Ala His Thr Thr His Cys Lys Asp Lys
    3730                3735                3740                
Lys Glu Phe Leu Cys Arg Asn Gln Arg Cys Leu Ser Ser Ser Leu Arg
3745                3750                3755                3760
Cys Asn Met Phe Asp Asp Cys Gly Asp Gly Ser Asp Glu Glu Asp Cys
                3765                3770                3775    
Ser Ile Asp Pro Lys Leu Thr Ser Cys Ala Thr Asn Ala Ser Ile Cys
            3780                3785                3790        
Gly Asp Glu Ala Arg Cys Val Arg Thr Glu Lys Ala Ala Tyr Cys Ala
        3795                3800                3805            
Cys Arg Ser Gly Phe His Thr Val Pro Gly Gln Pro Gly Cys Gln Asp
    3810                3815                3820                
Ile Asn Glu Cys Leu Arg Phe Gly Thr Cys Ser Gln Leu Cys Asn Asn
3825                3830                3835                3840
Thr Lys Gly Gly His Leu Cys Ser Cys Ala Arg Asn Phe Met Lys Thr
                3845                3850                3855    
His Asn Thr Cys Lys Ala Glu Gly Ser Glu Tyr Gln Val Leu Tyr Ile
            3860                3865                3870        
Ala Asp Asp Asn Glu Ile Arg Ser Leu Phe Pro Gly His Pro His Ser
        3875                3880                3885            
Ala Tyr Glu Gln Ala Phe Gln Gly Asp Glu Ser Val Arg Ile Asp Ala
    3890                3895                3900                
Met Asp Val His Val Lys Ala Gly Arg Val Tyr Trp Thr Asn Trp His
3905                3910                3915                3920
Thr Gly Thr Ile Ser Tyr Arg Ser Leu Pro Pro Ala Ala Pro Pro Thr
                3925                3930                3935    
Thr Ser Asn Arg His Arg Arg Gln Ile Asp Arg Gly Val Thr His Leu
            3940                3945                3950        
Asn Ile Ser Gly Leu Lys Met Pro Arg Gly Ile Ala Ile Asp Trp Val
        3955                3960                3965            
Ala Gly Asn Val Tyr Trp Thr Asp Ser Gly Arg Asp Val Ile Glu Val
    3970                3975                3980                
Ala Gln Met Lys Gly Glu Asn Arg Lys Thr Leu Ile Ser Gly Met Ile
3985                3990                3995                4000
Asp Glu Pro His Ala Ile Val Val Asp Pro Leu Arg Gly Thr Met Tyr
                4005                4010                4015    
Trp Ser Asp Trp Gly Asn His Pro Lys Ile Glu Thr Ala Ala Met Asp
            4020                4025                4030        
Gly Thr Leu Arg Glu Thr Leu Val Gln Asp Asn Ile Gln Trp Pro Thr
        4035                4040                4045            
Gly Leu Ala Val Asp Tyr His Asn Glu Arg Leu Tyr Trp Ala Asp Ala
    4050                4055                4060                
Lys Leu Ser Val Ile Gly Ser Ile Arg Leu Asn Gly Thr Asp Pro Ile
4065                4070                4075                4080
Val Ala Ala Asp Ser Lys Arg Gly Leu Ser His Pro Phe Ser Ile Asp
                4085                4090                4095    
Val Phe Glu Asp Tyr Ile Tyr Gly Val Thr Tyr Ile Asn Asn Arg Val
            4100                4105                4110        
Phe Lys Ile His Lys Phe Gly His Ser Pro Leu Val Asn Leu Thr Gly
        4115                4120                4125            
Gly Leu Ser His Ala Ser Asp Val Val Leu Tyr His Gln His Lys Gln
    4130                4135                4140                
Pro Glu Val Thr Asn Pro Cys Asp Arg Lys Lys Cys Glu Trp Leu Cys
4145                4150                4155                4160
Leu Leu Ser Pro Ser Gly Pro Val Cys Thr Cys Pro Asn Gly Lys Arg
                4165                4170                4175    
Leu Asp Asn Gly Thr Cys Val Pro Val Pro Ser Pro Thr Pro Pro Pro
            4180                4185                4190        
Asp Ala Pro Arg Pro Gly Thr Cys Asn Leu Gln Cys Phe Asn Gly Gly
        4195                4200                4205            
Ser Cys Phe Leu Asn Ala Arg Arg Gln Pro Lys Cys Arg Cys Gln Pro
    4210                4215                4220                
Arg Tyr Thr Gly Asp Lys Cys Glu Leu Asp Gln Cys Trp Glu His Cys
4225                4230                4235                4240
Arg Asn Gly Gly Thr Cys Ala Ala Ser Pro Ser Gly Met Pro Thr Cys
                4245                4250                4255    
Arg Cys Pro Thr Gly Phe Thr Gly Pro Lys Cys Thr Gln Gln Val Cys
            4260                4265                4270        
Ala Gly Tyr Cys Ala Asn Asn Ser Thr Cys Thr Val Asn Gln Gly Asn
        4275                4280                4285            
Gln Pro Gln Cys Arg Cys Leu Pro Gly Phe Leu Gly Asp Arg Cys Gln
    4290                4295                4300                
Tyr Arg Gln Cys Ser Gly Tyr Cys Glu Asn Phe Gly Thr Cys Gln Met
4305                4310                4315                4320
Ala Ala Asp Gly Ser Arg Gln Cys Arg Cys Thr Ala Tyr Phe Glu Gly
                4325                4330                4335    
Ser Arg Cys Glu Val Asn Lys Cys Ser Arg Cys Leu Glu Gly Ala Cys
            4340                4345                4350        
Val Val Asn Lys Gln Ser Gly Asp Val Thr Cys Asn Cys Thr Asp Gly
        4355                4360                4365            
Arg Val Ala Pro Ser Cys Leu Thr Cys Val Gly His Cys Ser Asn Gly
    4370                4375                4380                
Gly Ser Cys Thr Met Asn Ser Lys Met Met Pro Glu Cys Gln Cys Pro
4385                4390                4395                4400
Pro His Met Thr Gly Pro Arg Cys Glu Glu His Val Phe Ser Gln Gln
                4405                4410                4415    
Gln Pro Gly His Ile Ala Ser Ile Leu Ile Pro Leu Leu Leu Leu Leu
            4420                4425                4430        
Leu Leu Val Leu Val Ala Gly Val Val Phe Trp Tyr Lys Arg Arg Val
        4435                4440                4445            
Gln Gly Ala Lys Gly Phe Gln His Gln Arg Met Thr Asn Gly Ala Met
    4450                4455                4460                
Asn Val Glu Ile Gly Asn Pro Thr Tyr Lys Met Tyr Glu Gly Gly Glu
4465                4470                4475                4480
Pro Asp Asp Val Gly Gly Leu Leu Asp Ala Asp Phe Ala Leu Asp Pro
                4485                4490                4495    
Asp Lys Pro Thr Asn Phe Thr Asn Pro Val Tyr Ala Thr Leu Tyr Met
            4500                4505                4510        
Gly Gly His Gly Ser Arg His Ser Leu Ala Ser Thr Asp Glu Lys Arg
        4515                4520                4525            
Glu Leu Leu Gly Arg Gly Pro Glu Asp Glu Ile Gly Asp Pro Leu Ala
    4530                4535                4540                


<210> 5754
<211> 3086
<212> PRT
<213> Homo sapiens

<400> 5754
Gly Lys Ala Ser Asp Thr Glu Arg Gly Gly Val Leu Thr Ser Asn Asn
 1               5                  10                  15      
Ser Ser Asp Ser Pro Thr Gly Ser Gly Tyr Asn Thr Asp Val Ser Asp
            20                  25                  30          
Asp Asn Leu Pro Cys Asp Arg Thr Ser Pro Ser Ser Asp Leu Asn Gly
        35                  40                  45              
Asn Ser Val Ser Asp Glu Gln Asp Glu Gly Val Glu Ser Asp Asp Leu
    50                  55                  60                  
Lys Lys Asp Leu Pro Leu Met Pro Pro Pro Pro Asp Ser Cys Ser Met
65                  70                  75                  80  
Lys Leu Thr Ile Lys Glu Ile Trp Phe Ser Phe Ala Ala Pro Thr Asn
                85                  90                  95      
Val Arg Ser His Thr His Ala Phe Ser Arg Gln Leu Asn Leu Leu Ser
            100                 105                 110         
Thr Ala Thr Pro Ala Val Gly Ala Trp Leu Val Pro Ile Asp Gln Leu
        115                 120                 125             
Lys Ser Ser Leu Asn Lys Leu Glu Thr Glu Gly Thr Leu Arg Ile Cys
    130                 135                 140                 
Ala Val Met Gly Cys Ile Met Thr Glu Ala Leu Glu Asn Lys Ser Val
145                 150                 155                 160 
His Phe Pro Leu Arg Ser Lys Tyr Asn Arg Leu Thr Lys Val Ala Arg
                165                 170                 175     
Phe Leu Gln Glu Asn Pro Ser Cys Leu Leu Cys Asn Ile Leu His His
            180                 185                 190         
Tyr Leu His Gln Ala Asn Tyr Ser Ile Ile Asp Asp Ala Thr Met Ser
        195                 200                 205             
Asp Gly Leu Pro Ala Leu Val Thr Leu Lys Lys Gly Leu Val Ala Leu
    210                 215                 220                 
Ala Arg Gln Trp Met Lys Phe Ile Val Val Thr Pro Ala Phe Lys Gly
225                 230                 235                 240 
Val Ser Leu His Arg Pro Ala Gln Pro Leu Lys Pro Gln Ile Ala Met
                245                 250                 255     
Asp His Glu His Glu Asp Gly Leu Gly Leu Asp Asn Gly Gly Gly Leu
            260                 265                 270         
Gln Ser Asp Thr Ser Ala Asp Gly Ala Glu Phe Glu Phe Asp Ala Ala
        275                 280                 285             
Thr Val Ser Glu His Thr Met Leu Leu Glu Gly Thr Ala Asn Arg Pro
    290                 295                 300                 
Pro Pro Gly Ser Ser Gly Pro Val Thr Gly Ala Glu Ile Met Arg Lys
305                 310                 315                 320 
Leu Ser Lys Thr His Thr His Ser Asp Ser Ala Leu Lys Ile Lys Gly
                325                 330                 335     
Ile His Pro Tyr His Ser Leu Ser Tyr Thr Ser Gly Asp Thr Ala Thr
            340                 345                 350         
Asp Ser Pro Val His Val Gly Arg Ala Gly Met Pro Val Lys Asp Ser
        355                 360                 365             
Pro Arg Lys Glu Ser Leu Leu Ser Tyr Leu Thr Gly Ser Phe Pro Ser
    370                 375                 380                 
Leu His Asn Leu Leu Glu Gly Thr Pro Gln Arg Ser Ser Ala Ala Val
385                 390                 395                 400 
Lys Ser Ser Ser Leu Thr Arg Thr Gly Asn Thr Val Ala Thr Asp Met
                405                 410                 415     
Leu Ser Glu His Pro Leu Leu Ser Glu Pro Ser Ser Val Ser Phe Tyr
            420                 425                 430         
Asn Trp Met Ser Asn Ala Val Gly Asn Arg Gly Ser Val Leu Gln Glu
        435                 440                 445             
Ser Pro Val Thr Lys Ser Gly His Asn Ser Leu Pro Thr Gly Val Ala
    450                 455                 460                 
Pro Asn Leu Pro Thr Ile Pro Ser Ala Ser Asp Phe Asn Thr Val Leu
465                 470                 475                 480 
Ser Ser Asp Gln Asn Thr Leu Asp Gly Thr His Ser Gln His Ser Thr
                485                 490                 495     
Ser Gln Asp Asp Val Ala Gly Val Glu Glu Ala Asn Gln Gly Phe Pro
            500                 505                 510         
Ala Val Gln Leu Ala Asp Ala Gln Val Val Phe Lys Pro Leu Leu Ser
        515                 520                 525             
His Thr Gly Ile Gln Ser Gln Asp Thr Met Pro Phe Cys Tyr Arg Met
    530                 535                 540                 
Tyr Phe Gly Glu His Leu Ser Phe Ser Gly Thr Leu Asp Cys Leu Arg
545                 550                 555                 560 
Ala Asp Ile Val Asp Ser Asp Thr Ala Lys Glu Arg Lys Gly Lys Arg
                565                 570                 575     
Ala Arg Arg Gln Gly His Val Asn Leu Pro Pro Leu Glu Phe Lys Pro
            580                 585                 590         
Ala Leu Met Leu Gly Thr Phe Ser Ile Ser Ala Val Val Met Glu Lys
        595                 600                 605             
Ser Val Cys Thr Pro Gln Asn Ser Thr Ser Ala Leu Ser Phe His Asp
    610                 615                 620                 
Leu Ser Lys Arg Tyr Tyr Asn Thr Phe His Cys Asn Phe Thr Ile Ser
625                 630                 635                 640 
Cys Gln Ser Ile Ser Gln His Val Asp Met Ala Leu Val Arg Leu Ile
                645                 650                 655     
His Gln Phe Ser Thr Met Ile Asp Asp Ile Lys Ala Thr Gln Thr Asp
            660                 665                 670         
Ile Lys Leu Ser Arg Tyr Thr Ala Gly Ser Ala Ser Pro Thr Pro Thr
        675                 680                 685             
Phe Lys Thr Arg Lys His Arg Asp Phe Arg Ser Ser Asp Phe Ser Arg
    690                 695                 700                 
Ser Ser Arg Gly Ser Leu Asn Gly Gly Asn Arg Val Asn Asn Ala Lys
705                 710                 715                 720 
Asn Lys Arg Thr Asn Asn Glu Asn Asn Lys Lys Glu Ser Arg Asn Lys
                725                 730                 735     
Asn Ser Leu Gly Arg Ser Glu Arg Arg Thr Ser Lys Val Ser Arg Lys
            740                 745                 750         
Gly Ser Lys Asp Val Val Asp His Met Thr Ile His Met Asp Asp Ser
        755                 760                 765             
Asp Ser Ile Thr Val Ser Glu Gln Ser Glu Pro Ser Ala Glu Cys Trp
    770                 775                 780                 
Gln Asn Met Tyr Lys Leu Leu Asn Phe Tyr Ser Leu Ile Ser Asp Pro
785                 790                 795                 800 
Thr Gly Ile Leu Glu Lys Ser Ser Glu Thr Phe Gly Pro Ala Gly Val
                805                 810                 815     
Arg Ser Pro Thr Glu Pro Thr Cys Lys Val Val Phe Glu Asn Glu Gln
            820                 825                 830         
Asp Asn Ser Ser Leu Thr Lys Thr Gln Arg Lys Arg Ser Leu Val Thr
        835                 840                 845             
Ser Glu Pro Gln His Val Thr Leu Ile Val Phe Gly Ile Gly Met Val
    850                 855                 860                 
Asn Arg Thr His Leu Glu Ala Asp Ile Gly Gly Leu Thr Met Glu Ser
865                 870                 875                 880 
Glu Leu Lys Arg Ile His Gly Ser Phe Thr Leu Lys Glu Lys Met Lys
                885                 890                 895     
Asp Val Leu His Gln Lys Met Thr Glu Thr Cys Ala Thr Ala His Ile
            900                 905                 910         
Gly Gly Val Asn Ile Val Leu Leu Glu Gly Ile Thr Pro Asn Ile Gln
        915                 920                 925             
Leu Glu Asp Phe Pro Thr Ser Pro Thr Ser Thr Ala Lys Gln Glu Phe
    930                 935                 940                 
Leu Thr Val Val Lys Cys Ser Ile Ala Lys Ser Gln Ala Leu Tyr Ser
945                 950                 955                 960 
Ala Gln Arg Gly Leu Lys Thr Asn Asn Ala Ala Val Phe Lys Val Gly
                965                 970                 975     
Ala Ile Ser Ile Asn Ile Pro Gln His Pro Ala Thr Leu His Ser Met
            980                 985                 990         
Met Val Arg Ser Ser His Gln Leu Ser Lys Gln Ile Ser Asp Leu Ile
        995                 1000                1005            
Arg Gln Pro Ser Thr Ala Pro Gln Pro Val Lys Glu Asp Ile Ala Thr
    1010                1015                1020                
Pro Leu Pro Ser Glu Lys Thr Pro Thr Ser Val Asn Gln Thr Pro Val
1025                1030                1035                1040
Glu Thr Asn Glu Phe Pro Gln Leu Pro Glu Gly Leu Glu Lys Lys Pro
                1045                1050                1055    
Ile Val Leu Lys Phe Ser Ala Met Leu Asp Gly Ile Ala Ile Gly Ala
            1060                1065                1070        
Ala Leu Leu Pro Ser Leu Lys Ala Glu Tyr Lys Met Gly Arg Met Arg
        1075                1080                1085            
Ser His Gly Met Thr Gly Ala Gln Thr Arg Phe Thr Phe Glu Leu Pro
    1090                1095                1100                
Asn His Arg Leu Arg Phe Thr Ser Lys Val Ser Ala Thr Asp Met Ser
1105                1110                1115                1120
Thr Ile Pro Pro Ser Ala Ser Leu Asn Leu Pro Pro Val Thr Met Ser
                1125                1130                1135    
Gly Lys Tyr Ile Met Glu Glu His Asp Ser Tyr Ser Asp Gln Val Trp
            1140                1145                1150        
Ser Ile Asp Glu Leu Pro Ser Lys Gln Gly Tyr Tyr Leu Gln Gly Asn
        1155                1160                1165            
Tyr Leu Arg Cys Val Ala Glu Val Gly Ser Phe Glu His Asn Leu Thr
    1170                1175                1180                
Thr Asp Leu Leu Asn His Leu Val Phe Val Gln Lys Val Phe Met Lys
1185                1190                1195                1200
Glu Val Asn Glu Val Ile Gln Lys Val Ser Gly Gly Glu Gln Pro Ile
                1205                1210                1215    
Pro Leu Trp Asn Glu His Asp Gly Thr Ala Asp Gly Asp Lys Pro Lys
            1220                1225                1230        
Ile Leu Leu Tyr Ser Leu Asn Leu Gln Phe Lys Gly Ile Gln Val Thr
        1235                1240                1245            
Ala Thr Thr Pro Ser Met Arg Ala Val Arg Phe Glu Thr Gly Leu Ile
    1250                1255                1260                
Glu Leu Glu Leu Ser Asn Arg Leu Gln Thr Lys Ala Ser Pro Gly Ser
1265                1270                1275                1280
Ser Ser Tyr Leu Lys Leu Phe Gly Lys Cys Gln Val Asp Leu Asn Leu
                1285                1290                1295    
Ala Leu Gly Gln Ile Val Lys His Gln Val Tyr Glu Glu Ala Gly Ser
            1300                1305                1310        
Asp Phe His Gln Val Ala Tyr Phe Lys Thr Arg Ile Gly Leu Arg Asn
        1315                1320                1325            
Ala Leu Arg Glu Glu Ile Ser Gly Ser Ser Asp Arg Glu Ala Val Leu
    1330                1335                1340                
Ile Thr Leu Asn Arg Pro Ile Val Tyr Ala Gln Pro Val Ala Phe Asp
1345                1350                1355                1360
Arg Ala Val Leu Phe Trp Leu Asn Tyr Lys Ala Ala Tyr Asp Asn Trp
                1365                1370                1375    
Asn Glu Gln Arg Met Ala Leu His Lys Asp Ile His Met Ala Thr Lys
            1380                1385                1390        
Glu Val Val Asp Met Leu Pro Gly Ile Gln Gln Thr Ser Ala Gln Ala
        1395                1400                1405            
Phe Gly Thr Leu Phe Leu Gln Leu Thr Val Asn Asp Leu Gly Ile Cys
    1410                1415                1420                
Leu Pro Ile Thr Asn Thr Ala Gln Ser Asn His Thr Gly Asp Leu Asp
1425                1430                1435                1440
Thr Gly Ser Ala Leu Val Leu Thr Ile Glu Ser Thr Leu Ile Thr Ala
                1445                1450                1455    
Cys Ser Ser Glu Ser Leu Val Ser Lys Gly His Phe Lys Asn Phe Cys
            1460                1465                1470        
Ile Arg Phe Ala Asp Gly Phe Glu Thr Ser Trp Asp Asp Trp Lys Pro
        1475                1480                1485            
Glu Ile His Gly Asp Leu Val Met Asn Ala Cys Val Val Pro Asp Gly
    1490                1495                1500                
Thr Tyr Glu Val Cys Ser Arg Thr Thr Gly Gln Ala Ala Ala Glu Ser
1505                1510                1515                1520
Ser Ser Ala Gly Thr Trp Thr Leu Asn Val Leu Trp Lys Met Cys Gly
                1525                1530                1535    
Ile Asp Val His Met Asp Pro Asn Ile Gly Lys Arg Leu Asn Ala Leu
            1540                1545                1550        
Gly Asn Thr Leu Thr Thr Leu Thr Gly Glu Glu Asp Ile Asp Asp Ile
        1555                1560                1565            
Ala Asp Leu Asn Ser Val Asn Ile Ala Asp Leu Ser Asp Glu Asp Glu
    1570                1575                1580                
Val Asp Thr Met Ser Pro Thr Ile His Thr Glu Ala Thr Asp Tyr Arg
1585                1590                1595                1600
Arg Gln Ala Ala Ser Ala Ser Gln Pro Gly Glu Leu Arg Gly Arg Lys
                1605                1610                1615    
Ile Met Lys Arg Ile Val Asp Ile Arg Glu Leu Asn Glu Gln Ala Lys
            1620                1625                1630        
Val Ile Asp Asp Leu Lys Lys Leu Gly Ala Ser Glu Gly Thr Ile Asn
        1635                1640                1645            
Gln Glu Ile Gln Arg Tyr Gln Gln Leu Glu Ser Val Ala Val Asn Asp
    1650                1655                1660                
Ile Arg Arg Asp Val Arg Lys Lys Leu Arg Arg Ser Ser Met Arg Ala
1665                1670                1675                1680
Ala Ser Leu Lys Asp Lys Trp Gly Leu Ser Tyr Lys Pro Ser Tyr Ser
                1685                1690                1695    
Arg Ser Lys Ser Ile Ser Ala Ser Gly Arg Pro Pro Leu Lys Arg Met
            1700                1705                1710        
Glu Arg Ala Ser Ser Arg Val Gly Glu Thr Glu Glu Leu Pro Glu Ile
        1715                1720                1725            
Arg Val Asp Ala Ala Ser Pro Gly Pro Arg Val Thr Phe Asn Ile Gln
    1730                1735                1740                
Asp Thr Phe Pro Glu Glu Thr Glu Leu Asp Leu Leu Ser Val Thr Ile
1745                1750                1755                1760
Glu Gly Pro Ser His Tyr Ser Ser Asn Ser Glu Gly Ser Cys Ser Val
                1765                1770                1775    
Phe Ser Ser Pro Lys Thr Pro Gly Gly Phe Ser Pro Gly Ile Pro Phe
            1780                1785                1790        
Gln Thr Glu Glu Gly Arg Arg Asp Asp Ser Leu Ser Ser Thr Ser Glu
        1795                1800                1805            
Asp Ser Glu Lys Asp Glu Lys Asp Glu Asp His Glu Arg Glu Arg Phe
    1810                1815                1820                
Tyr Ile Tyr Arg Lys Pro Ser His Thr Ser Arg Lys Lys Ala Thr Gly
1825                1830                1835                1840
Phe Ala Ala Val His Gln Leu Phe Thr Glu Arg Trp Pro Thr Thr Pro
                1845                1850                1855    
Val Asn Arg Ser Leu Ser Gly Thr Ala Thr Glu Arg Asn Ile Asp Phe
            1860                1865                1870        
Glu Leu Asp Ile Arg Val Glu Ile Asp Ser Gly Lys Cys Val Leu His
        1875                1880                1885            
Pro Thr Thr Leu Leu Gln Glu His Asp Asp Ile Ser Leu Arg Arg Ser
    1890                1895                1900                
Tyr Asp Arg Ser Ser Arg Ser Leu Asp Gln Asp Ser Pro Ser Lys Lys
1905                1910                1915                1920
Lys Lys Phe Gln Thr Asn Tyr Ala Ser Thr Thr His Leu Met Thr Gly
                1925                1930                1935    
Lys Lys Val Pro Ser Ser Leu Gln Thr Lys Pro Ser Asp Leu Glu Thr
            1940                1945                1950        
Thr Val Phe Tyr Ile Pro Gly Val Asp Val Lys Leu His Tyr Asn Ser
        1955                1960                1965            
Lys Thr Leu Lys Thr Glu Ser Pro Asn Ala Ser Arg Gly Ser Ser Leu
    1970                1975                1980                
Pro Arg Thr Leu Ser Lys Glu Ser Lys Leu Tyr Gly Met Lys Asp Ser
1985                1990                1995                2000
Ala Thr Ser Pro Pro Ser Pro Pro Leu Pro Ser Thr Val Gln Ser Lys
                2005                2010                2015    
Thr Asn Thr Leu Leu Pro Pro Gln Pro Pro Pro Ile Pro Ala Ala Lys
            2020                2025                2030        
Gly Lys Gly Ser Gly Gly Val Lys Thr Ala Lys Leu Tyr Ala Trp Val
        2035                2040                2045            
Ala Leu Gln Ser Leu Pro Glu Glu Met Val Ile Ser Pro Cys Leu Leu
    2050                2055                2060                
Asp Phe Leu Glu Lys Ala Leu Glu Thr Ile Pro Ile Thr Pro Val Glu
2065                2070                2075                2080
Arg Asn Tyr Thr Ala Val Ser Ser Gln Asp Glu Asp Met Gly His Phe
                2085                2090                2095    
Glu Ile Pro Asp Pro Met Glu Glu Ser Thr Thr Ser Leu Val Ser Ser
            2100                2105                2110        
Ser Thr Ser Ala Tyr Ser Ser Phe Pro Val Asp Val Val Val Tyr Val
        2115                2120                2125            
Arg Val Gln Pro Ser Gln Ile Lys Phe Ser Cys Leu Pro Val Ser Arg
    2130                2135                2140                
Val Glu Cys Met Leu Lys Leu Pro Ser Leu Asp Leu Val Phe Ser Ser
2145                2150                2155                2160
Asn Arg Gly Glu Leu Glu Thr Leu Gly Thr Thr Tyr Pro Ala Glu Thr
                2165                2170                2175    
Leu Ser Pro Gly Gly Asn Ala Thr Gln Ser Gly Thr Lys Thr Ser Ala
            2180                2185                2190        
Ser Lys Thr Gly Ile Pro Gly Ser Ser Gly Leu Gly Ser Pro Leu Gly
        2195                2200                2205            
Arg Ser Arg His Ser Ser Ser Gln Ser Asp Leu Thr Ser Ser Ser Ser
    2210                2215                2220                
Ser Ser Ser Gly Leu Ser Phe Thr Ala Cys Met Ser Asp Phe Ser Leu
2225                2230                2235                2240
Tyr Val Phe His Pro Tyr Gly Ala Gly Lys Gln Lys Thr Ala Val Ser
                2245                2250                2255    
Gly Leu Thr Pro Gly Ser Gly Gly Leu Gly Asn Val Asp Glu Glu Pro
            2260                2265                2270        
Thr Ser Val Thr Gly Arg Lys Asp Ser Leu Ser Ile Asn Leu Glu Phe
        2275                2280                2285            
Val Lys Val Ser Leu Ser Arg Ile Arg Arg Ser Gly Gly Ala Ser Phe
    2290                2295                2300                
Phe Glu Ser Gln Ser Val Ser Lys Ser Ala Ser Lys Met Asp Thr Thr
2305                2310                2315                2320
Leu Ile Asn Ile Ser Ala Val Cys Asp Ile Gly Ser Ala Ser Phe Lys
                2325                2330                2335    
Tyr Asp Met Arg Arg Leu Ser Glu Ile Leu Ala Phe Pro Arg Ala Trp
            2340                2345                2350        
Tyr Arg Arg Ser Ile Ala Arg Arg Leu Phe Leu Gly Asp Gln Thr Ile
        2355                2360                2365            
Asn Leu Pro Thr Ser Gly Pro Gly Thr Pro Asp Ser Ile Glu Gly Val
    2370                2375                2380                
Ser Gln His Leu Ser Pro Glu Ser Ser Arg Lys Ala Tyr Cys Lys Thr
2385                2390                2395                2400
Trp Glu Gln Pro Ser Gln Ser Ala Ser Phe Thr His Met Pro Gln Ser
                2405                2410                2415    
Pro Asn Val Phe Asn Glu His Met Thr Asn Ser Thr Met Ser Pro Gly
            2420                2425                2430        
Thr Val Gly Gln Ser Leu Lys Ser Pro Ala Ser Ile Arg Ser Arg Ser
        2435                2440                2445            
Val Ser Asp Ser Ser Val Pro Arg Arg Asp Ser Leu Ser Lys Thr Ser
    2450                2455                2460                
Thr Pro Phe Asn Lys Ser Asn Lys Ala Ala Ser Gln Gln Gly Thr Pro
2465                2470                2475                2480
Trp Glu Thr Leu Val Val Phe Ala Ile Asn Leu Lys Gln Leu Asn Val
                2485                2490                2495    
Gln Met Asn Met Ser Asn Val Met Gly Asn Thr Thr Trp Thr Thr Ser
            2500                2505                2510        
Gly Leu Lys Ser Gln Gly Arg Leu Ser Val Gly Ser Asn Arg Asp Arg
        2515                2520                2525            
Glu Ile Ser Met Ser Val Gly Leu Gly Arg Ser Gln Leu Asp Ser Lys
    2530                2535                2540                
Gly Gly Val Val Gly Gly Thr Ile Asp Val Asn Ala Leu Glu Met Val
2545                2550                2555                2560
Ala His Ile Ser Glu His Pro Asn Gln Gln Pro Ser His Lys Ile Gln
                2565                2570                2575    
Ile Thr Met Gly Ser Thr Glu Ala Arg Val Asp Tyr Met Gly Ser Ser
            2580                2585                2590        
Ile Leu Met Gly Ile Phe Ser Asn Ala Asp Leu Lys Leu Gln Asp Glu
        2595                2600                2605            
Trp Lys Val Asn Leu Tyr Asn Thr Leu Asp Ser Ser Ile Thr Asp Lys
    2610                2615                2620                
Ser Glu Ile Phe Val His Gly Asp Leu Lys Trp Asp Ile Phe Gln Val
2625                2630                2635                2640
Met Ile Ser Arg Ser Thr Thr Pro Asp Leu Ile Lys Ile Gly Met Lys
                2645                2650                2655    
Leu Gln Glu Phe Phe Thr Gln Gln Phe Asp Thr Ser Lys Arg Ala Leu
            2660                2665                2670        
Ser Thr Trp Gly Pro Val Pro Tyr Leu Pro Pro Lys Thr Met Thr Ser
        2675                2680                2685            
Asn Leu Glu Lys Ser Ser Gln Glu Gln Leu Leu Asp Ala Ala His His
    2690                2695                2700                
Arg His Trp Pro Gly Val Leu Lys Val Val Ser Gly Cys His Ile Ser
2705                2710                2715                2720
Leu Phe Gln Ile Pro Leu Pro Glu Asp Gly Met Gln Phe Gly Gly Ser
                2725                2730                2735    
Met Ser Leu His Gly Asn His Met Thr Leu Ala Cys Phe His Gly Pro
            2740                2745                2750        
Asn Phe Arg Ser Lys Ser Trp Ala Leu Phe His Leu Glu Glu Pro Asn
        2755                2760                2765            
Ile Ala Phe Trp Thr Glu Ala Gln Lys Ile Trp Glu Asp Gly Ser Ser
    2770                2775                2780                
Asp His Ser Thr Tyr Ile Val Gln Thr Leu Asp Phe His Leu Gly His
2785                2790                2795                2800
Asn Thr Met Val Thr Lys Pro Cys Gly Ala Leu Glu Ser Pro Met Ala
                2805                2810                2815    
Thr Ile Thr Lys Ile Thr Arg Arg Arg His Glu Asn Pro Pro His Gly
            2820                2825                2830        
Val Ala Ser Val Lys Glu Trp Phe Asn Tyr Val Thr Ala Thr Arg Asn
        2835                2840                2845            
Glu Glu Leu Asn Leu Leu Arg Asn Val Asp Ala Asn Asn Thr Glu Asn
    2850                2855                2860                
Ser Thr Thr Val Lys Asn Ser Ser Leu Leu Ser Gly Phe Arg Gly Gly
2865                2870                2875                2880
Ser Ser Tyr Asn His Glu Thr Glu Thr Ile Phe Ala Leu Pro Arg Met
                2885                2890                2895    
Gln Leu Asp Phe Lys Ser Ile His Val Gln Glu Pro Gln Glu Pro Ser
            2900                2905                2910        
Leu Gln Asp Ala Ser Leu Lys Pro Lys Val Glu Cys Ser Val Val Thr
        2915                2920                2925            
Glu Phe Thr Asp His Ile Cys Val Thr Met Asp Ala Glu Leu Ile Met
    2930                2935                2940                
Phe Leu His Asp Leu Val Ser Ala Tyr Leu Lys Glu Lys Glu Lys Ala
2945                2950                2955                2960
Ile Phe Pro Pro Arg Ile Leu Ser Thr Arg Pro Gly Gln Lys Ser Pro
                2965                2970                2975    
Ile Ile Ile His Asp Asp Asn Ser Ser Asp Lys Asp Arg Glu Asp Ser
            2980                2985                2990        
Ile Thr Tyr Thr Thr Val Asp Trp Arg Asp Phe Met Cys Asn Thr Trp
        2995                3000                3005            
His Leu Glu Pro Thr Leu Arg Leu Ile Ser Trp Thr Gly Arg Lys Ile
    3010                3015                3020                
Asp Pro Val Gly Val Asp Tyr Ile Leu Gln Lys Leu Gly Phe His His
3025                3030                3035                3040
Ala Arg Thr Thr Ile Pro Lys Trp Leu Gln Arg Gly Val Met Asp Pro
                3045                3050                3055    
Leu Asp Lys Val Leu Ser Val Leu Ile Lys Lys Leu Gly Thr Ala Leu
            3060                3065                3070        
Gln Asp Glu Lys Glu Lys Lys Gly Lys Asp Lys Glu Glu His
        3075                3080                3085    


<210> 5755
<211> 538
<212> PRT
<213> Homo sapiens

<400> 5755
Met Gly Gly Ser Leu Cys Ala Gly Val Phe Ile Cys Pro Ser Cys Gln
 1               5                  10                  15      
Val Gly Glu Leu Arg Leu His Ala Leu Ser Gly Ser Pro Cys Gly Ile
            20                  25                  30          
Cys Glu Gln Leu Asp Val Phe Asp Thr Ser Val Thr Ala Lys Lys Cys
        35                  40                  45              
Lys Leu Arg Leu Leu Glu Glu Leu Glu Asp Thr Trp Leu Pro Tyr Leu
    50                  55                  60                  
Thr Pro Lys Asp Asp Glu Phe Tyr Gln Gln Trp Gln Leu Lys Tyr Pro
65                  70                  75                  80  
Lys Leu Ile Leu Arg Glu Ala Ser Ser Val Ser Glu Glu Leu His Lys
                85                  90                  95      
Glu Val Gln Glu Ala Phe Leu Thr Leu His Lys His Gly Cys Leu Phe
            100                 105                 110         
Arg Asp Leu Val Arg Ile Gln Gly Lys Asp Leu Leu Thr Pro Val Ser
        115                 120                 125             
Arg Ile Leu Ile Gly Asn Pro Gly Cys Thr Tyr Lys Tyr Leu Asn Thr
    130                 135                 140                 
Arg Leu Phe Thr Val Pro Trp Pro Val Lys Gly Ser Asn Ile Lys His
145                 150                 155                 160 
Thr Glu Ala Glu Ile Ala Ala Ala Cys Glu Thr Phe Leu Lys Leu Asn
                165                 170                 175     
Asp Tyr Leu Gln Ile Glu Thr Ile Gln Ala Leu Glu Glu Leu Ala Ala
            180                 185                 190         
Lys Glu Lys Ala Asn Glu Asp Ala Val Pro Leu Cys Met Ser Ala Asp
        195                 200                 205             
Phe Pro Arg Val Gly Met Gly Ser Ser Tyr Asn Gly Gln Asp Glu Val
    210                 215                 220                 
Asp Ile Lys Ser Arg Ala Ala Tyr Asn Val Thr Leu Leu Asn Phe Met
225                 230                 235                 240 
Asp Pro Gln Lys Met Pro Tyr Leu Lys Glu Glu Pro Tyr Phe Gly Met
                245                 250                 255     
Gly Lys Met Ala Val Ser Trp His His Asp Glu Asn Leu Val Asp Arg
            260                 265                 270         
Ser Ala Val Ala Val Tyr Ser Tyr Ser Cys Glu Gly Pro Glu Glu Glu
        275                 280                 285             
Ser Glu Asp Asp Ser His Leu Glu Gly Arg Asp Pro Asp Ile Trp His
    290                 295                 300                 
Val Gly Phe Lys Ile Ser Trp Asp Ile Glu Thr Pro Gly Leu Ala Ile
305                 310                 315                 320 
Pro Leu His Gln Gly Asp Cys Tyr Phe Met Leu Asp Asp Leu Asn Ala
                325                 330                 335     
Thr His Gln His Cys Val Leu Ala Gly Ser Gln Pro Arg Phe Ser Ser
            340                 345                 350         
Thr His Arg Val Ala Glu Cys Ser Thr Gly Thr Leu Asp Tyr Ile Leu
        355                 360                 365             
Gln Arg Cys Gln Leu Ala Leu Gln Asn Val Cys Asp Asp Val Asp Asn
    370                 375                 380                 
Asp Asp Val Ser Leu Lys Ser Phe Glu Pro Ala Val Leu Lys Gln Gly
385                 390                 395                 400 
Glu Glu Ile His Asn Glu Val Glu Phe Glu Trp Leu Arg Gln Phe Trp
                405                 410                 415     
Phe Gln Gly Asn Arg Tyr Arg Lys Cys Thr Asp Trp Trp Cys Gln Pro
            420                 425                 430         
Met Ala Gln Leu Glu Ala Leu Trp Lys Lys Met Glu Gly Val Thr Asn
        435                 440                 445             
Ala Val Leu His Glu Val Lys Arg Glu Gly Leu Pro Val Glu Gln Arg
    450                 455                 460                 
Asn Glu Ile Leu Thr Ala Ile Leu Ala Ser Leu Thr Ala Arg Gln Asn
465                 470                 475                 480 
Leu Arg Arg Glu Trp His Ala Arg Cys Gln Ser Arg Ile Ala Arg Thr
                485                 490                 495     
Leu Pro Ala Asp Gln Lys Pro Glu Cys Arg Pro Tyr Trp Glu Lys Asp
            500                 505                 510         
Asp Ala Ser Met Pro Leu Pro Phe Asp Leu Thr Asp Ile Val Ser Glu
        515                 520                 525             
Leu Arg Gly Gln Leu Leu Glu Ala Lys Pro
    530                 535             


<210> 5756
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 5756
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15      
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30          
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45              
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60                  
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80  
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95      
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110         
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125             
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140                 
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160 
Pro Ala Met Gly Met Asn Thr Gly Thr Asn Ala Gly Met Asn Pro Gly
                165                 170                 175     
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190         
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asp Met Gln Tyr Pro
        195                 200                 205             
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220                 
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240 
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255     
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270         
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285             
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln
    290                 295                 300                 
Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala
305                 310                 315                 320 
Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys
                325                 330                 335     
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
            340                 345                 350         
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His
        355                 360                 365             
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser
    370                 375                 380                 
Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
385                 390                 395                 400 
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
                405                 410                 415     
Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly
            420                 425                 430         
Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln
        435                 440                 445             
Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile
    450                 455                 460                 
Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met
465                 470                 475                 480 
Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro
                485                 490                 495     
Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser
            500                 505                 510         
Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu
        515                 520                 525             
Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met
    530                 535                 540                 
Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala
545                 550                 555                 560 
Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr
                565                 570                 575     
Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe
            580                 585                 590         
Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu
        595                 600                 605             
Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn
    610                 615                 620                 
Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile
625                 630                 635                 640 
Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn
                645                 650                 655     
Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly
            660                 665                 670         
Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu
        675                 680                 685             
Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro
    690                 695                 700                 
Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met
705                 710                 715                 720 
Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His
                725                 730                 735     
Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly
            740                 745                 750         
Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr
        755                 760                 765             
Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro
    770                 775                 780                 
Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser
785                 790                 795                 800 
Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His
                805                 810                 815     
Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro
            820                 825                 830         
Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser
        835                 840                 845             
Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro
    850                 855                 860                 
Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro
865                 870                 875                 880 
Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln
                885                 890                 895     
Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln
            900                 905                 910         
Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Asn
        915                 920                 925             
Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala
    930                 935                 940                 
Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr
945                 950                 955                 960 
Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val
                965                 970                 975     
Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr
            980                 985                 990         
Gln Pro Glu Asp Ile Ser Glu Ser Lys Val Glu Asp Cys Lys Met Glu
        995                 1000                1005            
Ser Thr Glu Thr Glu Glu Arg Ser Thr Glu Leu Lys Thr Glu Ile Lys
    1010                1015                1020                
Glu Glu Glu Asp Gln Pro Ser Thr Ser Ala Thr Gln Ser Ser Pro Ala
1025                1030                1035                1040
Pro Gly Gln Ser Lys Lys Lys Ile Phe Lys Pro Glu Glu Leu Arg Gln
                1045                1050                1055    
Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser
            1060                1065                1070        
Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp
        1075                1080                1085            
Tyr Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg
    1090                1095                1100                
Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp
1105                1110                1115                1120
Ile Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser
                1125                1130                1135    
Arg Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu
            1140                1145                1150        
Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu
        1155                1160                1165            
Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr
    1170                1175                1180                
Ile Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe
1185                1190                1195                1200
Cys Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly
                1205                1210                1215    
Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser
            1220                1225                1230        
Lys Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr
        1235                1240                1245            
Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile
    1250                1255                1260                
Ile Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala
1265                1270                1275                1280
Arg Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro Ser Thr
                1285                1290                1295    
Arg Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu Arg Arg
            1300                1305                1310        
Gln Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val His Ala
        1315                1320                1325            
Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg Phe Val
    1330                1335                1340                
Asp Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu
1345                1350                1355                1360
Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe Gly Met
                1365                1370                1375    
His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln Arg Arg
            1380                1385                1390        
Val Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro Lys Cys
        1395                1400                1405            
Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu Glu Tyr
    1410                1415                1420                
Val Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys Pro Pro
1425                1430                1435                1440
Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp Gln Lys
                1445                1450                1455    
Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met Leu Asp
            1460                1465                1470        
Lys Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile Phe Lys
        1475                1480                1485            
Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro Tyr Phe
    1490                1495                1500                
Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys Glu Leu
1505                1510                1515                1520
Glu Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser Asn Glu
                1525                1530                1535    
Ser Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys Lys Asn
            1540                1545                1550        
Asn Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly Asn Lys
        1555                1560                1565            
Lys Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys Leu
    1570                1575                1580                
Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile Arg Leu
1585                1590                1595                1600
Ile Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp Pro Asp
                1605                1610                1615    
Pro Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe Leu Thr
            1620                1625                1630        
Leu Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg Ala Gln
        1635                1640                1645            
Trp Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser Gln Asp
    1650                1655                1660                
Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg
1665                1670                1675                1680
Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu Cys Ile Thr Cys Tyr
                1685                1690                1695    
Asn Thr Lys Asn His Asp His Lys Met Glu Lys Leu Gly Leu Gly Leu
            1700                1705                1710        
Asp Asp Glu Ser Asn Asn Gln Gln Ala Ala Ala Thr Gln Ser Pro Gly
        1715                1720                1725            
Asp Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile Gln Ser Leu Val His
    1730                1735                1740                
Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu Pro Ser Cys Gln Lys
1745                1750                1755                1760
Met Lys Arg Val Val Gln His Thr Lys Gly Cys Lys Arg Lys Thr Asn
                1765                1770                1775    
Gly Gly Cys Pro Ile Cys Lys Gln Leu Ile Ala Leu Cys Cys Tyr His
            1780                1785                1790        
Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val Pro Phe Cys Leu Asn
        1795                1800                1805            
Ile Lys Gln Lys Leu Arg Gln Gln Gln Leu Gln His Arg Leu Gln Gln
    1810                1815                1820                
Ala Gln Met Leu Arg Arg Arg Met Ala Ser Met Gln Arg Thr Gly Val
1825                1830                1835                1840
Val Gly Gln Gln Gln Gly Leu Pro Ser Pro Thr Pro Ala Thr Pro Thr
                1845                1850                1855    
Thr Pro Thr Gly Gln Gln Pro Thr Thr Pro Gln Thr Pro Gln Pro Thr
            1860                1865                1870        
Ser Gln Pro Gln Pro Thr Pro Pro Asn Ser Met Pro Pro Tyr Leu Pro
        1875                1880                1885            
Arg Thr Gln Ala Ala Gly Pro Val Ser Gln Gly Lys Ala Ala Gly Gln
    1890                1895                1900                
Val Thr Pro Pro Thr Pro Pro Gln Thr Ala Gln Pro Pro Leu Pro Gly
1905                1910                1915                1920
Pro Pro Pro Thr Ala Val Glu Met Ala Met Gln Ile Gln Arg Ala Ala
                1925                1930                1935    
Glu Thr Gln Arg Gln Met Ala His Val Gln Ile Phe Gln Arg Pro Ile
            1940                1945                1950        
Gln His Gln Met Pro Pro Met Thr Pro Met Ala Pro Met Gly Met Asn
        1955                1960                1965            
Pro Pro Pro Met Thr Arg Gly Pro Ser Gly His Leu Glu Pro Gly Met
    1970                1975                1980                
Gly Pro Thr Gly Met Gln Gln Gln Pro Pro Trp Ser Gln Gly Gly Leu
1985                1990                1995                2000
Pro Gln Pro Gln Gln Leu Gln Ser Gly Met Pro Arg Pro Ala Met Met
                2005                2010                2015    
Ser Val Ala Gln His Gly Gln Pro Leu Asn Met Ala Pro Gln Pro Gly
            2020                2025                2030        
Leu Gly Gln Val Gly Ile Ser Pro Leu Lys Pro Gly Thr Val Ser Gln
        2035                2040                2045            
Gln Ala Leu Gln Asn Leu Leu Arg Thr Leu Arg Ser Pro Ser Ser Pro
    2050                2055                2060                
Leu Gln Gln Gln Gln Val Leu Ser Ile Leu His Ala Asn Pro Gln Leu
2065                2070                2075                2080
Leu Ala Ala Phe Ile Lys Gln Arg Ala Ala Lys Tyr Ala Asn Ser Asn
                2085                2090                2095    
Pro Gln Pro Ile Pro Gly Gln Pro Gly Met Pro Gln Gly Gln Pro Gly
            2100                2105                2110        
Leu Gln Pro Pro Thr Met Pro Gly Gln Gln Gly Val His Ser Asn Pro
        2115                2120                2125            
Ala Met Gln Asn Met Asn Pro Met Gln Ala Gly Val Gln Arg Ala Gly
    2130                2135                2140                
Leu Pro Gln Gln Gln Pro Gln Gln Gln Leu Gln Pro Pro Met Gly Gly
2145                2150                2155                2160
Met Ser Pro Gln Ala Gln Gln Met Asn Met Asn His Asn Thr Met Pro
                2165                2170                2175    
Ser Gln Phe Arg Asp Ile Leu Arg Arg Gln Gln Met Met Gln Gln Gln
            2180                2185                2190        
Gln Gln Gln Gly Ala Gly Pro Gly Ile Gly Pro Gly Met Ala Asn His
        2195                2200                2205            
Asn Gln Phe Gln Gln Pro Gln Gly Val Gly Tyr Pro Pro Gln Pro Gln
    2210                2215                2220                
Gln Arg Met Gln His His Met Gln Gln Met Gln Gln Gly Asn Met Gly
2225                2230                2235                2240
Gln Ile Gly Gln Leu Pro Gln Ala Leu Gly Ala Glu Ala Gly Ala Ser
                2245                2250                2255    
Leu Gln Ala Tyr Gln Gln Arg Leu Leu Gln Gln Gln Met Gly Ser Pro
            2260                2265                2270        
Val Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu Pro Asn Gln
        2275                2280                2285            
Ala Gln Ser Pro His Leu Gln Gly Gln Gln Ile Pro Asn Ser Leu Ser
    2290                2295                2300                
Asn Gln Val Arg Ser Pro Gln Pro Val Pro Ser Pro Arg Pro Gln Ser
2305                2310                2315                2320
Gln Pro Pro His Ser Ser Pro Ser Pro Arg Met Gln Pro Gln Pro Ser
                2325                2330                2335    
Pro His His Val Ser Pro Gln Thr Ser Ser Pro His Pro Gly Leu Val
            2340                2345                2350        
Ala Ala Gln Ala Asn Pro Met Glu Gln Gly His Phe Ala Ser Pro Asp
        2355                2360                2365            
Gln Asn Ser Met Leu Ser Gln Leu Ala Ser Asn Pro Gly Met Ala Asn
    2370                2375                2380                
Leu His Gly Ala Ser Ala Thr Asp Leu Gly Leu Ser Thr Asp Asn Ser
2385                2390                2395                2400
Asp Leu Asn Ser Asn Leu Ser Gln Ser Thr Leu Asp Ile His
                2405                2410                


<210> 5757
<211> 2327
<212> PRT
<213> Homo sapiens

<400> 5757
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro
 1               5                  10                  15      
Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp
            20                  25                  30          
Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile
        35                  40                  45              
Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu
    50                  55                  60                  
Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln
65                  70                  75                  80  
Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly
                85                  90                  95      
Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser
            100                 105                 110         
Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln
        115                 120                 125             
Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn
    130                 135                 140                 
Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln
145                 150                 155                 160 
Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly
                165                 170                 175     
Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met
            180                 185                 190         
Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro
        195                 200                 205             
Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln
    210                 215                 220                 
Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln
225                 230                 235                 240 
Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro
                245                 250                 255     
Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu
            260                 265                 270         
Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala
        275                 280                 285             
Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Val Gln
    290                 295                 300                 
Gln Pro Gly Leu Val Thr Pro Val Ala Gln Gly Met Gly Ser Gly Ala
305                 310                 315                 320 
His Thr Ala Asp Pro Glu Lys Arg Lys Leu Ile Gln Gln Gln Leu Val
                325                 330                 335     
Leu Leu Leu His Ala His Lys Cys Gln Arg Arg Glu Gln Ala Asn Gly
            340                 345                 350         
Glu Val Arg Gln Cys Asn Leu Pro His Cys Arg Thr Met Lys Asn Val
        355                 360                 365             
Leu Asn His Met Thr His Cys Gln Ser Gly Lys Ser Cys Gln Val Ala
    370                 375                 380                 
His Cys Ala Ser Ser Arg Gln Ile Ile Ser His Trp Lys Asn Cys Thr
385                 390                 395                 400 
Arg His Asp Cys Pro Val Cys Leu Pro Leu Lys Asn Ala Gly Asp Lys
                405                 410                 415     
Arg Asn Gln Gln Pro Ile Leu Thr Gly Ala Pro Val Gly Leu Gly Asn
            420                 425                 430         
Pro Ser Ser Leu Gly Val Gly Gln Gln Ser Ala Pro Asn Leu Ser Thr
        435                 440                 445             
Val Ser Gln Ile Asp Pro Ser Ser Ile Glu Arg Ala Tyr Ala Ala Leu
    450                 455                 460                 
Gly Leu Pro Tyr Gln Val Asn Gln Met Pro Thr Gln Pro Gln Val Gln
465                 470                 475                 480 
Ala Lys Asn Gln Gln Asn Gln Gln Pro Gly Gln Ser Pro Gln Gly Met
                485                 490                 495     
Arg Pro Met Ser Asn Met Ser Asn Pro Met Met Ser Glu Asn Ala Ser
            500                 505                 510         
Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala Gln Pro Ser Thr Thr
        515                 520                 525             
Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr Gln Asp Leu Arg Asn
    530                 535                 540                 
His Leu Val His Lys Leu Val Gln Ala Ile Phe Pro Thr Pro Asp Pro
545                 550                 555                 560 
Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu Val Ala Tyr Ala Arg
                565                 570                 575     
Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn Asn Arg Ala Glu Tyr
            580                 585                 590         
Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu
        595                 600                 605             
Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn Met Leu Pro Asn Ala
    610                 615                 620                 
Ala Gly Met Val Pro Val Ser Met Asn Pro Gly Pro Asn Met Gly Gln
625                 630                 635                 640 
Pro Gln Pro Gly Met Thr Ser Ser Asn Gln Leu Phe Tyr Asn Phe Leu
                645                 650                 655     
Pro Ser Pro Leu Gln Pro Ser Ser Pro Ile Leu Leu Ser Leu Ala Phe
            660                 665                 670         
Leu Tyr Leu Ile Ser Leu Thr Leu Gly Ala Phe Asp Asp Phe Ser Tyr
        675                 680                 685             
Ser Arg Ile Thr Ile Met Lys Gln Phe Gly Asp Leu Cys Phe Phe Phe
    690                 695                 700                 
Gln Pro Met Gly Tyr Gly Pro Arg Met Gln Gln Pro Ser Asn Gln Gly
705                 710                 715                 720 
Gln Phe Leu Pro Gln Thr Gln Phe Pro Ser Gln Gly Met Asn Val Thr
                725                 730                 735     
Asn Ile Pro Leu Ala Pro Ser Ser Gly Gln Ala Pro Val Ser Ser Cys
            740                 745                 750         
Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His Ile
        755                 760                 765             
His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro Ser
    770                 775                 780                 
Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser Ile
785                 790                 795                 800 
Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro Thr
                805                 810                 815     
Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro Pro
            820                 825                 830         
Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln Val
        835                 840                 845             
Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln Gln
    850                 855                 860                 
Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr Ala
865                 870                 875                 880 
Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala Val
                885                 890                 895     
Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr Glu
            900                 905                 910         
Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val Lys
        915                 920                 925             
Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr Gln
    930                 935                 940                 
Pro Glu Asp Ile Ser Glu Ser Lys Val Glu Asp Cys Lys Met Glu Ser
945                 950                 955                 960 
Thr Glu Thr Glu Glu Arg Ser Thr Glu Leu Lys Thr Glu Ile Lys Glu
                965                 970                 975     
Glu Glu Asp Gln Pro Ser Thr Ser Ala Thr Gln Ser Ser Pro Ala Pro
            980                 985                 990         
Gly Gln Ser Lys Lys Lys Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala
        995                 1000                1005            
Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu
    1010                1015                1020                
Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr
1025                1030                1035                1040
Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile Lys Arg Lys
                1045                1050                1055    
Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile
            1060                1065                1070        
Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg
        1075                1080                1085            
Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu Gln Glu Ile
    1090                1095                1100                
Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu
1105                1110                1115                1120
Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile
                1125                1130                1135    
Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys
            1140                1145                1150        
Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser Leu Gly Asp
        1155                1160                1165            
Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys
    1170                1175                1180                
Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu Cys Thr Glu
1185                1190                1195                1200
Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His Glu Ile Ile
                1205                1210                1215    
Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg
            1220                1225                1230        
Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg
        1235                1240                1245            
Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu Arg Arg Gln
    1250                1255                1260                
Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val His Ala Ser
1265                1270                1275                1280
Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg Phe Val Asp
                1285                1290                1295    
Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe
            1300                1305                1310        
Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe Gly Met His
        1315                1320                1325            
Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln Arg Arg Val
    1330                1335                1340                
Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro Lys Cys Leu
1345                1350                1355                1360
Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu Glu Tyr Val
                1365                1370                1375    
Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys Pro Pro Ser
            1380                1385                1390        
Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp Gln Lys Ile
        1395                1400                1405            
Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met Leu Asp Lys
    1410                1415                1420                
Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile Phe Lys Gln
1425                1430                1435                1440
Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu
                1445                1450                1455    
Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys Glu Leu Glu
            1460                1465                1470        
Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser
        1475                1480                1485            
Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn
    1490                1495                1500                
Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys
1505                1510                1515                1520
Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr
                1525                1530                1535    
Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile Arg Leu Ile
            1540                1545                1550        
Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp Pro Asp Pro
        1555                1560                1565            
Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe Leu Thr Leu
    1570                1575                1580                
Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg Ala Gln Trp
1585                1590                1595                1600
Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser Gln Asp Arg
                1605                1610                1615    
Phe Val Tyr Thr Cys Asn Glu Cys Lys His His Val Glu Thr Arg Trp
            1620                1625                1630        
His Cys Thr Val Cys Glu Asp Tyr Asp Leu Cys Ile Thr Cys Tyr Asn
        1635                1640                1645            
Thr Lys Asn His Asp His Lys Met Glu Lys Leu Gly Leu Gly Leu Asp
    1650                1655                1660                
Asp Glu Ser Asn Asn Gln Gln Ala Ala Ala Thr Gln Ser Pro Gly Asp
1665                1670                1675                1680
Ser Arg Arg Leu Ser Ile Gln Arg Cys Ile Gln Ser Leu Val His Ala
                1685                1690                1695    
Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu Pro Ser Cys Gln Lys Met
            1700                1705                1710        
Lys Arg Val Val Gln His Thr Lys Gly Cys Lys Arg Lys Thr Asn Gly
        1715                1720                1725            
Gly Cys Pro Ile Cys Lys Gln Leu Ile Ala Leu Cys Cys Tyr His Ala
    1730                1735                1740                
Lys His Cys Gln Glu Asn Lys Cys Pro Val Pro Phe Cys Leu Asn Ile
1745                1750                1755                1760
Lys Gln Lys Leu Arg Gln Gln Gln Leu Gln His Arg Leu Gln Gln Ala
                1765                1770                1775    
Gln Met Leu Arg Arg Arg Met Ala Ser Met Gln Arg Thr Gly Val Val
            1780                1785                1790        
Gly Gln Gln Gln Gly Leu Pro Ser Pro Thr Pro Ala Thr Pro Thr Thr
        1795                1800                1805            
Pro Thr Gly Gln Gln Pro Thr Thr Pro Gln Thr Pro Gln Pro Thr Ser
    1810                1815                1820                
Gln Pro Gln Pro Thr Pro Pro Asn Ser Met Pro Pro Tyr Leu Pro Arg
1825                1830                1835                1840
Thr Gln Ala Ala Gly Pro Val Ser Gln Gly Lys Ala Ala Gly Gln Val
                1845                1850                1855    
Thr Pro Pro Thr Pro Pro Gln Thr Ala Gln Pro Pro Leu Pro Gly Pro
            1860                1865                1870        
Pro Pro Ala Ala Val Glu Met Ala Met Gln Ile Gln Arg Ala Ala Glu
        1875                1880                1885            
Thr Gln Arg Gln Met Ala His Val Gln Ile Phe Gln Arg Pro Ile Gln
    1890                1895                1900                
His Gln Met Pro Pro Met Thr Pro Met Ala Pro Met Gly Met Asn Pro
1905                1910                1915                1920
Pro Pro Met Thr Arg Gly Pro Ser Gly His Leu Glu Pro Gly Met Gly
                1925                1930                1935    
Pro Thr Gly Met Gln Gln Gln Pro Pro Trp Ser Gln Gly Gly Leu Pro
            1940                1945                1950        
Gln Pro Gln Gln Leu Gln Ser Gly Met Pro Arg Pro Ala Met Met Ser
        1955                1960                1965            
Val Ala Gln His Gly Gln Pro Leu Asn Met Ala Pro Gln Pro Gly Leu
    1970                1975                1980                
Gly Gln Val Gly Ile Ser Pro Leu Lys Pro Gly Thr Val Ser Gln Gln
1985                1990                1995                2000
Ala Leu Gln Asn Leu Leu Arg Thr Leu Arg Ser Pro Ser Ser Pro Leu
                2005                2010                2015    
Gln Gln Gln Gln Val Leu Ser Ile Leu His Ala Asn Pro Gln Leu Leu
            2020                2025                2030        
Ala Ala Phe Ile Lys Gln Arg Ala Ala Lys Tyr Ala Asn Ser Asn Pro
        2035                2040                2045            
Gln Pro Ile Pro Gly Gln Pro Gly Met Pro Gln Gly Gln Pro Gly Leu
    2050                2055                2060                
Gln Pro Pro Thr Met Pro Gly Gln Gln Gly Val His Ser Asn Pro Ala
2065                2070                2075                2080
Met Gln Asn Met Asn Pro Met Gln Ala Gly Val Gln Arg Ala Gly Leu
                2085                2090                2095    
Pro Gln Gln Gln Pro Gln Gln Gln Leu Gln Pro Pro Met Gly Gly Met
            2100                2105                2110        
Ser Pro Gln Ala Gln Gln Met Asn Met Asn His Asn Thr Met Pro Ser
        2115                2120                2125            
Gln Phe Arg Asp Ile Leu Arg Arg Gln Gln Met Met Gln Gln Gln Gln
    2130                2135                2140                
Gln Gln Gly Ala Gly Pro Gly Ile Gly Pro Gly Met Ala Asn His Asn
2145                2150                2155                2160
Gln Phe Gln Gln Pro Gln Gly Val Gly Tyr Pro Pro Gln Gln Gln Gln
                2165                2170                2175    
Arg Met Gln His His Met Gln Gln Met Gln Gln Gly Asn Met Gly Gln
            2180                2185                2190        
Ile Gly Gln Leu Pro Gln Ala Leu Gly Ala Glu Ala Gly Ala Ser Leu
        2195                2200                2205            
Gln Ala Tyr Gln Gln Arg Leu Leu Gln Gln Gln Met Gly Ser Pro Val
    2210                2215                2220                
Gln Pro Asn Pro Met Ser Pro Gln Gln His Met Leu Pro Asn Gln Ala
2225                2230                2235                2240
Gln Ser Pro His Leu Gln Gly Gln Gln Ile Pro Asn Ser Leu Ser Asn
                2245                2250                2255    
Gln Val Arg Ser Pro Gln Pro Val Pro Ser Pro Arg Pro Gln Ser Gln
            2260                2265                2270        
Pro Pro His Ser Ser Pro Ser Pro Arg Met Gln Pro Gln Pro Ser Pro
        2275                2280                2285            
His His Val Ser Pro Gln Thr Ser Ser Pro His Pro Gly Leu Val Ala
    2290                2295                2300                
Ala Gln Ala Asn Pro Met Glu Gln Gly His Phe Ala Ser Pro Asp Gln
2305                2310                2315                2320
Asn Ser Met Leu Ser Gln Leu
                2325        


<210> 5758
<211> 3419
<212> PRT
<213> Homo sapiens

<400> 5758
Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys
 1               5                  10                  15      
Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe
            20                  25                  30          
Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu
        35                  40                  45              
Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr
    50                  55                  60                  
Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile
65                  70                  75                  80  
Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys
                85                  90                  95      
Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser
            100                 105                 110         
Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp
        115                 120                 125             
Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val
    130                 135                 140                 
Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val
145                 150                 155                 160 
Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr
                165                 170                 175     
Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met
            180                 185                 190         
Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val
        195                 200                 205             
Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp
    210                 215                 220                 
Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu
225                 230                 235                 240 
Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr
                245                 250                 255     
Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn
            260                 265                 270         
Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro
        275                 280                 285             
Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu
    290                 295                 300                 
Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu
305                 310                 315                 320 
Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala
                325                 330                 335     
Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr
            340                 345                 350         
Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser
        355                 360                 365             
Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser
    370                 375                 380                 
Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu
385                 390                 395                 400 
Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile
                405                 410                 415     
Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu
            420                 425                 430         
Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg
        435                 440                 445             
Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val
    450                 455                 460                 
Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys
465                 470                 475                 480 
Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser
                485                 490                 495     
Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro
            500                 505                 510         
Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn
        515                 520                 525             
Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr
    530                 535                 540                 
Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn
545                 550                 555                 560 
Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn
                565                 570                 575     
Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr
            580                 585                 590         
Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp
        595                 600                 605             
Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala
    610                 615                 620                 
Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His
625                 630                 635                 640 
Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr
                645                 650                 655     
Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg
            660                 665                 670         
Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr
        675                 680                 685             
Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro
    690                 695                 700                 
Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp
705                 710                 715                 720 
Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala
                725                 730                 735     
Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp
            740                 745                 750         
Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr
        755                 760                 765             
Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met
    770                 775                 780                 
Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly
785                 790                 795                 800 
Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu
                805                 810                 815     
Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu
            820                 825                 830         
Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys
        835                 840                 845             
Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln
    850                 855                 860                 
Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu
865                 870                 875                 880 
Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn
                885                 890                 895     
Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr
            900                 905                 910         
Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val
        915                 920                 925             
Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys
    930                 935                 940                 
Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys
945                 950                 955                 960 
Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser
                965                 970                 975     
Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys
            980                 985                 990         
Trp Ala Gly Leu Leu Gly Pro Ile Ser Asn His Ser Phe Gly Gly Ser
        995                 1000                1005            
Phe Arg Thr Ala Ser Asn Lys Glu Ile Lys Leu Ser Glu His Asn Ile
    1010                1015                1020                
Lys Lys Ser Lys Met Phe Phe Lys Asp Ile Glu Glu Gln Tyr Pro Thr
1025                1030                1035                1040
Ser Leu Ala Cys Val Glu Ile Val Asn Thr Leu Ala Leu Asp Asn Gln
                1045                1050                1055    
Lys Lys Leu Ser Lys Pro Gln Ser Ile Asn Thr Val Ser Ala His Leu
            1060                1065                1070        
Gln Ser Ser Val Val Val Ser Asp Cys Lys Asn Ser His Ile Thr Pro
        1075                1080                1085            
Gln Met Leu Phe Ser Lys Gln Asp Phe Asn Ser Asn His Asn Leu Thr
    1090                1095                1100                
Pro Ser Gln Lys Ala Glu Ile Thr Glu Leu Ser Thr Ile Leu Glu Glu
1105                1110                1115                1120
Ser Gly Ser Gln Phe Glu Phe Thr Gln Phe Arg Lys Pro Ser Tyr Ile
                1125                1130                1135    
Leu Gln Lys Ser Thr Phe Glu Val Pro Glu Asn Gln Met Thr Ile Leu
            1140                1145                1150        
Lys Thr Thr Ser Glu Glu Cys Arg Asp Ala Asp Leu His Val Ile Met
        1155                1160                1165            
Asn Ala Pro Ser Ile Gly Gln Val Asp Ser Ser Lys Gln Phe Glu Gly
    1170                1175                1180                
Thr Val Glu Ile Lys Arg Lys Phe Ala Gly Leu Leu Lys Asn Asp Cys
1185                1190                1195                1200
Asn Lys Ser Ala Ser Gly Tyr Leu Thr Asp Glu Asn Glu Val Gly Phe
                1205                1210                1215    
Arg Gly Phe Tyr Ser Ala His Gly Thr Lys Leu Asn Val Ser Thr Glu
            1220                1225                1230        
Ala Leu Gln Lys Ala Val Lys Leu Phe Ser Asp Ile Glu Asn Ile Ser
        1235                1240                1245            
Glu Glu Thr Ser Ala Glu Val His Pro Ile Ser Leu Ser Ser Ser Lys
    1250                1255                1260                
Cys His Asp Ser Val Val Ser Met Phe Lys Ile Glu Asn His Asn Asp
1265                1270                1275                1280
Lys Thr Val Ser Glu Lys Asn Asn Lys Cys Gln Leu Ile Leu Gln Asn
                1285                1290                1295    
Asn Ile Glu Met Thr Thr Gly Thr Phe Val Glu Glu Ile Thr Glu Asn
            1300                1305                1310        
Tyr Lys Arg Asn Thr Glu Asn Glu Asp Asn Lys Tyr Thr Ala Ala Ser
        1315                1320                1325            
Arg Asn Ser His Asn Leu Glu Phe Asp Gly Ser Asp Ser Ser Lys Asn
    1330                1335                1340                
Asp Thr Val Cys Ile His Lys Asp Glu Thr Asp Leu Leu Phe Thr Asp
1345                1350                1355                1360
Gln His Asn Ile Cys Leu Lys Leu Ser Gly Gln Phe Met Lys Glu Gly
                1365                1370                1375    
Asn Thr Gln Ile Lys Glu Asp Leu Ser Asp Leu Thr Phe Leu Glu Val
            1380                1385                1390        
Ala Lys Ala Gln Glu Ala Cys His Gly Asn Thr Ser Asn Lys Glu Gln
        1395                1400                1405            
Leu Thr Ala Thr Lys Thr Glu Gln Asn Ile Lys Asp Phe Glu Thr Ser
    1410                1415                1420                
Asp Thr Phe Phe Gln Thr Ala Ser Gly Lys Asn Ile Ser Val Ala Lys
1425                1430                1435                1440
Glu Ser Phe Asn Lys Ile Val Asn Phe Phe Asp Gln Lys Pro Glu Glu
                1445                1450                1455    
Leu His Asn Phe Ser Leu Asn Ser Glu Leu His Ser Asp Ile Arg Lys
            1460                1465                1470        
Asn Lys Met Asp Ile Leu Ser Tyr Glu Glu Thr Asp Ile Val Lys His
        1475                1480                1485            
Lys Ile Leu Lys Glu Ser Val Pro Val Gly Thr Gly Asn Gln Leu Val
    1490                1495                1500                
Thr Phe Gln Gly Gln Pro Glu Arg Asp Glu Lys Ile Lys Glu Pro Thr
1505                1510                1515                1520
Leu Leu Gly Phe His Thr Ala Ser Gly Lys Lys Val Lys Ile Ala Lys
                1525                1530                1535    
Glu Ser Leu Asp Lys Val Lys Asn Leu Phe Asp Glu Lys Glu Gln Gly
            1540                1545                1550        
Thr Ser Glu Ile Thr Ser Phe Ser His Gln Trp Ala Lys Thr Leu Lys
        1555                1560                1565            
Tyr Arg Glu Ala Cys Lys Asp Leu Glu Leu Ala Cys Glu Thr Ile Glu
    1570                1575                1580                
Ile Thr Ala Ala Pro Lys Cys Lys Glu Met Gln Asn Ser Leu Asn Asn
1585                1590                1595                1600
Asp Lys Asn Leu Val Ser Ile Glu Thr Val Val Pro Pro Lys Leu Leu
                1605                1610                1615    
Ser Asp Asn Leu Cys Arg Gln Thr Glu Asn Leu Lys Thr Ser Lys Ser
            1620                1625                1630        
Ile Phe Leu Lys Val Lys Val His Glu Asn Val Glu Lys Glu Thr Ala
        1635                1640                1645            
Lys Ser Pro Ala Thr Cys Tyr Thr Asn Gln Ser Pro Tyr Ser Val Ile
    1650                1655                1660                
Glu Asn Ser Ala Leu Ala Phe Tyr Thr Ser Cys Ser Arg Lys Thr Ser
1665                1670                1675                1680
Val Ser Gln Thr Ser Leu Leu Glu Ala Lys Lys Trp Leu Arg Glu Gly
                1685                1690                1695    
Ile Phe Asp Gly Gln Pro Glu Arg Ile Asn Thr Ala Asp Tyr Val Gly
            1700                1705                1710        
Asn Tyr Leu Tyr Glu Asn Asn Ser Asn Ser Thr Ile Ala Glu Asn Asp
        1715                1720                1725            
Lys Asn His Leu Ser Glu Lys Gln Asp Thr Tyr Leu Ser Asn Ser Ser
    1730                1735                1740                
Met Ser Asn Ser Tyr Ser Tyr His Ser Asp Glu Val Tyr Asn Asp Ser
1745                1750                1755                1760
Gly Tyr Leu Ser Lys Asn Lys Leu Asp Ser Gly Ile Glu Pro Val Leu
                1765                1770                1775    
Lys Asn Val Glu Asp Gln Lys Asn Thr Ser Phe Ser Lys Val Ile Ser
            1780                1785                1790        
Asn Val Lys Asp Ala Asn Ala Tyr Pro Gln Thr Val Asn Glu Asp Ile
        1795                1800                1805            
Cys Val Glu Glu Leu Val Thr Ser Ser Ser Pro Cys Lys Asn Lys Asn
    1810                1815                1820                
Ala Ala Ile Lys Leu Ser Ile Ser Asn Ser Asn Asn Phe Glu Val Gly
1825                1830                1835                1840
Pro Pro Ala Phe Arg Ile Ala Ser Gly Lys Ile Val Cys Val Ser His
                1845                1850                1855    
Glu Thr Ile Lys Lys Val Lys Asp Ile Phe Thr Asp Ser Phe Ser Lys
            1860                1865                1870        
Val Ile Lys Glu Asn Asn Glu Asn Lys Ser Lys Ile Cys Gln Thr Lys
        1875                1880                1885            
Ile Met Ala Gly Cys Tyr Glu Ala Leu Asp Asp Ser Glu Asp Ile Leu
    1890                1895                1900                
His Asn Ser Leu Asp Asn Asp Glu Cys Ser Thr His Ser His Lys Val
1905                1910                1915                1920
Phe Ala Asp Ile Gln Ser Glu Glu Ile Leu Gln His Asn Gln Asn Met
                1925                1930                1935    
Ser Gly Leu Glu Lys Val Ser Lys Ile Ser Pro Cys Asp Val Ser Leu
            1940                1945                1950        
Glu Thr Ser Asp Ile Cys Lys Cys Ser Ile Gly Lys Leu His Lys Ser
        1955                1960                1965            
Val Ser Ser Ala Asn Thr Cys Gly Ile Phe Ser Thr Ala Ser Gly Lys
    1970                1975                1980                
Ser Val Gln Val Ser Asp Ala Ser Leu Gln Asn Ala Arg Gln Val Phe
1985                1990                1995                2000
Ser Glu Ile Glu Asp Ser Thr Lys Gln Val Phe Ser Lys Val Leu Phe
                2005                2010                2015    
Lys Ser Asn Glu His Ser Asp Gln Leu Thr Arg Glu Glu Asn Thr Ala
            2020                2025                2030        
Ile Arg Thr Pro Glu His Leu Ile Ser Gln Lys Gly Phe Ser Tyr Asn
        2035                2040                2045            
Val Val Asn Ser Ser Ala Phe Ser Gly Phe Ser Thr Ala Ser Gly Lys
    2050                2055                2060                
Gln Val Ser Ile Leu Glu Ser Ser Leu His Lys Val Lys Gly Val Leu
2065                2070                2075                2080
Glu Glu Phe Asp Leu Ile Arg Thr Glu His Ser Leu His Tyr Ser Pro
                2085                2090                2095    
Thr Ser Arg Gln Asn Val Ser Lys Ile Leu Pro Arg Val Asp Lys Arg
            2100                2105                2110        
Asn Pro Glu His Cys Val Asn Ser Glu Met Glu Lys Thr Cys Ser Lys
        2115                2120                2125            
Glu Phe Lys Leu Ser Asn Asn Leu Asn Val Glu Gly Gly Ser Ser Glu
    2130                2135                2140                
Asn Asn His Ser Ile Lys Val Ser Pro Tyr Leu Ser Gln Phe Gln Gln
2145                2150                2155                2160
Asp Lys Gln Gln Leu Val Leu Gly Thr Lys Val Ser Leu Val Glu Asn
                2165                2170                2175    
Ile His Val Leu Gly Lys Glu Gln Ala Ser Pro Lys Asn Val Lys Met
            2180                2185                2190        
Glu Ile Gly Lys Thr Glu Thr Phe Ser Asp Val Pro Val Lys Thr Asn
        2195                2200                2205            
Ile Glu Val Cys Ser Thr Tyr Ser Lys Asp Ser Glu Asn Tyr Phe Glu
    2210                2215                2220                
Thr Glu Ala Val Glu Ile Ala Lys Ala Phe Met Glu Asp Asp Glu Leu
2225                2230                2235                2240
Thr Asp Ser Lys Leu Pro Ser His Ala Thr His Ser Leu Phe Thr Cys
                2245                2250                2255    
Pro Glu Asn Glu Glu Met Val Leu Ser Asn Ser Arg Ile Gly Lys Arg
            2260                2265                2270        
Arg Gly Glu Pro Leu Ile Leu Val Gly Glu Pro Ser Ile Lys Arg Asn
        2275                2280                2285            
Leu Leu Asn Glu Phe Asp Arg Ile Ile Glu Asn Gln Glu Lys Ser Leu
    2290                2295                2300                
Lys Ala Ser Lys Ser Thr Pro Asp Gly Thr Ile Lys Asp Arg Arg Leu
2305                2310                2315                2320
Phe Met His His Val Ser Leu Glu Pro Ile Thr Cys Val Pro Phe Arg
                2325                2330                2335    
Thr Thr Lys Glu Arg Gln Glu Ile Gln Asn Pro Asn Phe Thr Ala Pro
            2340                2345                2350        
Gly Gln Glu Phe Leu Ser Lys Ser His Leu Tyr Glu His Leu Thr Leu
        2355                2360                2365            
Glu Lys Ser Ser Ser Asn Leu Ala Val Ser Gly His Pro Phe Tyr Gln
    2370                2375                2380                
Val Ser Ala Thr Arg Asn Glu Lys Met Arg His Leu Ile Thr Thr Gly
2385                2390                2395                2400
Arg Pro Thr Lys Val Phe Val Pro Pro Phe Lys Thr Lys Ser His Phe
                2405                2410                2415    
His Arg Val Glu Gln Cys Val Arg Asn Ile Asn Leu Glu Glu Asn Arg
            2420                2425                2430        
Gln Lys Gln Asn Ile Asp Gly His Gly Ser Asp Asp Ser Lys Asn Lys
        2435                2440                2445            
Ile Asn Asp Asn Glu Ile His Gln Phe Asn Lys Asn Asn Ser Asn Gln
    2450                2455                2460                
Ala Val Ala Val Thr Phe Thr Lys Cys Glu Glu Glu Pro Leu Asp Leu
2465                2470                2475                2480
Ile Thr Ser Leu Gln Asn Ala Arg Asp Ile Gln Asp Met Arg Ile Lys
                2485                2490                2495    
Lys Lys Gln Arg Gln Arg Val Phe Pro Gln Pro Gly Ser Leu Tyr Leu
            2500                2505                2510        
Ala Lys Thr Ser Thr Leu Pro Arg Ile Ser Leu Lys Ala Ala Val Gly
        2515                2520                2525            
Gly Gln Val Pro Ser Ala Cys Ser His Lys Gln Leu Tyr Thr Tyr Gly
    2530                2535                2540                
Val Ser Lys His Cys Ile Lys Ile Asn Ser Lys Asn Ala Glu Ser Phe
2545                2550                2555                2560
Gln Phe His Thr Glu Asp Tyr Phe Gly Lys Glu Ser Leu Trp Thr Gly
                2565                2570                2575    
Lys Gly Ile Gln Leu Ala Asp Gly Gly Trp Leu Ile Pro Ser Asn Asp
            2580                2585                2590        
Gly Lys Ala Gly Lys Glu Glu Phe Tyr Arg Ala Leu Cys Asp Thr Pro
        2595                2600                2605            
Gly Val Asp Pro Lys Leu Ile Ser Arg Ile Trp Val Tyr Asn His Tyr
    2610                2615                2620                
Arg Trp Ile Ile Trp Lys Leu Ala Ala Met Glu Cys Ala Phe Pro Lys
2625                2630                2635                2640
Glu Phe Ala Asn Arg Cys Leu Ser Pro Glu Arg Val Leu Leu Gln Leu
                2645                2650                2655    
Lys Tyr Arg Gln Tyr Asp Thr Glu Ile Asp Arg Ser Arg Arg Ser Ala
            2660                2665                2670        
Ile Lys Lys Ile Met Glu Arg Asp Asp Thr Ala Ala Lys Thr Leu Val
        2675                2680                2685            
Leu Cys Val Ser Asp Ile Ile Ser Leu Ser Ala Asn Ile Ser Glu Thr
    2690                2695                2700                
Ser Ser Asn Lys Thr Ser Ser Ala Asp Thr Gln Lys Val Ala Ile Ile
2705                2710                2715                2720
Glu Leu Thr Asp Gly Trp Tyr Ala Val Lys Ala Gln Leu Asp Pro Pro
                2725                2730                2735    
Leu Leu Ala Val Leu Lys Asn Gly Arg Leu Thr Val Gly Gln Lys Ile
            2740                2745                2750        
Ile Leu His Gly Ala Glu Leu Val Gly Ser Pro Asp Ala Cys Thr Pro
        2755                2760                2765            
Leu Glu Ala Pro Glu Ser Leu Met Leu Lys Ile Ser Ala Asn Ser Thr
    2770                2775                2780                
Arg Pro Ala Arg Trp Tyr Thr Lys Leu Gly Phe Phe Pro Asp Pro Arg
2785                2790                2795                2800
Pro Phe Pro Leu Pro Leu Ser Ser Leu Phe Ser Asp Gly Gly Asn Val
                2805                2810                2815    
Gly Cys Val Asp Val Ile Ile Gln Arg Ala Tyr Pro Ile Gln Trp Met
            2820                2825                2830        
Glu Lys Thr Ser Ser Gly Leu Tyr Ile Phe Arg Asn Glu Arg Glu Glu
        2835                2840                2845            
Glu Lys Glu Ala Ala Lys Tyr Val Glu Ala Gln Gln Lys Arg Leu Glu
    2850                2855                2860                
Ala Leu Phe Thr Lys Ile Gln Glu Glu Phe Glu Glu His Glu Glu Asn
2865                2870                2875                2880
Thr Thr Lys Pro Tyr Leu Pro Ser Arg Ala Leu Thr Arg Gln Gln Val
                2885                2890                2895    
Arg Ala Leu Gln Asp Gly Ala Glu Leu Tyr Glu Ala Val Lys Asn Ala
            2900                2905                2910        
Ala Asp Pro Ala Tyr Leu Glu Gly Tyr Phe Ser Glu Glu Gln Leu Arg
        2915                2920                2925            
Ala Leu Asn Asn His Arg Gln Met Leu Asn Asp Lys Lys Gln Ala Gln
    2930                2935                2940                
Ile Gln Leu Glu Ile Arg Lys Ala Met Glu Ser Ala Glu Gln Lys Glu
2945                2950                2955                2960
Gln Gly Leu Ser Arg Asp Val Thr Thr Val Trp Lys Leu Arg Ile Val
                2965                2970                2975    
Ser Tyr Ser Lys Lys Glu Lys Asp Ser Val Ile Leu Ser Ile Trp Arg
            2980                2985                2990        
Pro Ser Ser Asp Leu Tyr Ser Leu Leu Thr Glu Gly Lys Arg Tyr Arg
        2995                3000                3005            
Ile Tyr His Leu Ala Thr Ser Lys Ser Lys Ser Lys Ser Glu Arg Ala
    3010                3015                3020                
Asn Ile Gln Leu Ala Ala Thr Lys Lys Thr Gln Tyr Gln Gln Leu Pro
3025                3030                3035                3040
Val Ser Asp Glu Ile Leu Phe Gln Ile Tyr Gln Pro Arg Glu Pro Leu
                3045                3050                3055    
His Phe Ser Lys Phe Leu Asp Pro Asp Phe Gln Pro Ser Cys Ser Glu
            3060                3065                3070        
Val Asp Leu Ile Gly Phe Val Val Ser Val Val Lys Lys Thr Gly Leu
        3075                3080                3085            
Ala Pro Phe Val Tyr Leu Ser Asp Glu Cys Tyr Asn Leu Leu Ala Ile
    3090                3095                3100                
Lys Phe Trp Ile Asp Leu Asn Glu Asp Ile Ile Lys Pro His Met Leu
3105                3110                3115                3120
Ile Ala Ala Ser Asn Leu Gln Trp Arg Pro Glu Ser Lys Ser Gly Leu
                3125                3130                3135    
Leu Thr Leu Phe Ala Gly Asp Phe Ser Val Phe Ser Ala Ser Pro Lys
            3140                3145                3150        
Glu Gly His Phe Gln Glu Thr Phe Asn Lys Met Lys Asn Thr Val Glu
        3155                3160                3165            
Asn Ile Asp Ile Leu Cys Asn Glu Ala Glu Asn Lys Leu Met His Ile
    3170                3175                3180                
Leu His Ala Asn Asp Pro Lys Trp Ser Thr Pro Thr Lys Asp Cys Thr
3185                3190                3195                3200
Ser Gly Pro Tyr Thr Ala Gln Ile Ile Pro Gly Thr Gly Asn Lys Leu
                3205                3210                3215    
Leu Met Ser Ser Pro Asn Cys Glu Ile Tyr Tyr Gln Ser Pro Leu Ser
            3220                3225                3230        
Leu Cys Met Ala Lys Arg Lys Ser Val Ser Thr Pro Val Ser Ala Gln
        3235                3240                3245            
Met Thr Ser Lys Ser Cys Lys Gly Glu Lys Glu Ile Asp Asp Gln Lys
    3250                3255                3260                
Asn Cys Lys Lys Arg Arg Ala Leu Asp Phe Leu Ser Arg Leu Pro Leu
3265                3270                3275                3280
Pro Pro Pro Val Ser Pro Ile Cys Thr Phe Val Ser Pro Ala Ala Gln
                3285                3290                3295    
Lys Ala Phe Gln Pro Pro Arg Ser Cys Gly Thr Lys Tyr Glu Thr Pro
            3300                3305                3310        
Ile Lys Lys Lys Glu Leu Asn Ser Pro Gln Met Thr Pro Phe Lys Lys
        3315                3320                3325            
Phe Asn Glu Ile Ser Leu Leu Glu Ser Asn Ser Ile Ala Asp Glu Glu
    3330                3335                3340                
Leu Ala Leu Ile Asn Thr Gln Ala Leu Leu Ser Gly Ser Thr Gly Glu
3345                3350                3355                3360
Lys Gln Phe Ile Ser Val Ser Glu Ser Thr Arg Thr Ala Pro Thr Ser
                3365                3370                3375    
Ser Glu Asp Tyr Leu Arg Leu Lys Arg Arg Cys Thr Thr Ser Leu Ile
            3380                3385                3390        
Lys Glu Gln Glu Ser Ser Gln Ala Ser Thr Glu Glu Cys Glu Lys Asn
        3395                3400                3405            
Lys Gln Asp Thr Ile Thr Thr Lys Lys Tyr Ile
    3410                3415                


<210> 5759
<211> 331
<212> PRT
<213> Homo sapiens

<400> 5759
Met Ala Ala Gly Leu Ala Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala
 1               5                  10                  15      
Gly Gly Pro Ala Pro Ala Gly Ala Ala Lys Met Lys Val Val Glu Glu
            20                  25                  30          
Pro Asn Ala Phe Gly Val Asn Asn Pro Phe Leu Pro Gln Ala Ser Arg
        35                  40                  45              
Leu Gln Ala Lys Arg Asp Pro Ser Pro Val Ser Asp Arg Phe Cys Ala
    50                  55                  60                  
Trp Thr Leu Gly Ile Ser Val Arg Ser Leu Pro Gly Pro Val His Leu
65                  70                  75                  80  
Phe Arg Leu Ser Gly Lys Cys Phe Ser Leu Val Glu Ser Thr Tyr Lys
                85                  90                  95      
Tyr Glu Phe Cys Pro Phe His Asn Val Thr Gln His Glu Gln Thr Phe
            100                 105                 110         
Arg Trp Asn Ala Tyr Ser Gly Ile Leu Gly Ile Trp His Glu Trp Glu
        115                 120                 125             
Ile Ala Asn Asn Thr Phe Thr Gly Met Trp Met Arg Asp Gly Asp Ala
    130                 135                 140                 
Cys Arg Ser Arg Ser Arg Gln Ser Lys Val Glu Leu Ala Cys Gly Lys
145                 150                 155                 160 
Ser Asn Arg Leu Ala His Val Ser Glu Pro Ser Thr Cys Val Tyr Ala
                165                 170                 175     
Leu Thr Phe Glu Thr Pro Leu Val Cys His Pro His Ala Leu Leu Val
            180                 185                 190         
Tyr Pro Thr Leu Pro Glu Ala Leu Gln Arg Gln Trp Asp Gln Val Glu
        195                 200                 205             
Gln Asp Leu Ala Asp Glu Leu Ile Thr Pro Gln Gly His Glu Lys Leu
    210                 215                 220                 
Leu Arg Thr Leu Phe Glu Asp Ala Gly Tyr Leu Lys Thr Pro Glu Glu
225                 230                 235                 240 
Asn Glu Pro Thr Gln Leu Glu Gly Gly Pro Asp Ser Leu Gly Phe Glu
                245                 250                 255     
Thr Leu Glu Asn Cys Arg Lys Ala His Lys Glu Leu Ser Lys Glu Ile
            260                 265                 270         
Lys Arg Leu Lys Gly Leu Leu Thr Gln His Gly Ile Pro Tyr Thr Arg
        275                 280                 285             
Pro Thr Gly Glu Asp Trp Pro Pro Gly Val Leu Ala Glu Thr Ser Asn
    290                 295                 300                 
Leu Glu His Leu Gly His Glu Thr Pro Arg Ala Lys Ser Pro Glu Gln
305                 310                 315                 320 
Leu Arg Gly Asp Pro Gly Leu Arg Gly Ser Leu
                325                 330     


<210> 5760
<211> 305
<212> PRT
<213> Homo sapiens

<400> 5760
Met Ala Ala Gly Leu Ala Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala
 1               5                  10                  15      
Gly Gly Pro Ala Pro Ala Gly Ala Ala Lys Met Lys Val Val Glu Glu
            20                  25                  30          
Pro Asn Ala Phe Gly Val Asn Asn Pro Phe Leu Pro Gln Ala Ser Arg
        35                  40                  45              
Leu Gln Ala Lys Arg Asp Pro Ser Pro Val Ser Gly Pro Val His Leu
    50                  55                  60                  
Phe Arg Leu Ser Gly Lys Cys Phe Ser Leu Val Glu Ser Thr Tyr Lys
65                  70                  75                  80  
Tyr Glu Phe Cys Pro Phe His Asn Val Thr Gln His Glu Gln Thr Phe
                85                  90                  95      
Arg Trp Asn Ala Tyr Ser Gly Ile Leu Gly Ile Trp His Glu Trp Glu
            100                 105                 110         
Ile Ala Asn Asn Thr Phe Thr Gly Met Trp Met Arg Asp Gly Asp Ala
        115                 120                 125             
Cys Arg Ser Arg Ser Arg Gln Ser Lys Val Glu Leu Ala Cys Gly Lys
    130                 135                 140                 
Ser Asn Arg Leu Ala His Val Ser Glu Pro Ser Thr Cys Val Tyr Ala
145                 150                 155                 160 
Leu Thr Phe Glu Thr Pro Leu Val Cys His Pro His Ala Leu Leu Val
                165                 170                 175     
Tyr Pro Thr Leu Pro Glu Ala Leu Gln Arg Gln Trp Asp Gln Val Glu
            180                 185                 190         
Gln Asp Leu Ala Asp Glu Leu Ile Thr Pro Gln Gly His Glu Lys Leu
        195                 200                 205             
Leu Arg Thr Leu Phe Glu Asp Ala Gly Tyr Leu Lys Thr Pro Glu Glu
    210                 215                 220                 
Asn Glu Pro Thr Gln Leu Glu Gly Gly Pro Asp Ser Leu Gly Phe Glu
225                 230                 235                 240 
Thr Leu Glu Asn Cys Arg Lys Ala His Lys Glu Leu Ser Lys Glu Ile
                245                 250                 255     
Lys Arg Leu Lys Gly Leu Leu Thr Gln His Gly Ile Pro Tyr Thr Arg
            260                 265                 270         
Pro Thr Glu Thr Ser Asn Leu Glu His Leu Gly His Glu Thr Pro Arg
        275                 280                 285             
Ala Lys Ser Pro Glu Gln Leu Arg Gly Asp Pro Gly Leu Arg Gly Ser
    290                 295                 300                 
Leu
305 


<210> 5761
<211> 411
<212> PRT
<213> Homo sapiens

<400> 5761
Met Ser Pro Ala Arg Leu Arg Pro Arg Leu His Phe Cys Leu Val Leu
 1               5                  10                  15      
Leu Leu Leu Leu Val Val Pro Ala Ala Trp Gly Cys Gly Pro Gly Arg
            20                  25                  30          
Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys Leu Val Pro Leu Ala
        35                  40                  45              
Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys Thr Leu Gly Ala Ser
    50                  55                  60                  
Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser Glu Arg Phe Lys Glu
65                  70                  75                  80  
Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn
                85                  90                  95      
Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys Asp Arg Leu Asn
            100                 105                 110         
Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg
        115                 120                 125             
Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser Glu Glu Ser Leu
    130                 135                 140                 
His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg
145                 150                 155                 160 
Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp
                165                 170                 175     
Trp Val Tyr Tyr Glu Ser Lys Ala His Val His Cys Ser Val Lys Ser
            180                 185                 190         
Glu His Ser Ala Ala Ala Lys Thr Gly Gly Cys Phe Pro Ala Gly Ala
        195                 200                 205             
Gln Val Arg Leu Glu Ser Gly Ala Arg Val Ala Leu Ser Ala Val Arg
    210                 215                 220                 
Pro Gly Asp Arg Val Leu Ala Met Gly Glu Asp Gly Ser Pro Thr Phe
225                 230                 235                 240 
Ser Asp Val Leu Ile Phe Leu Asp Arg Glu Pro His Arg Leu Arg Ala
                245                 250                 255     
Phe Gln Val Ile Glu Thr Gln Asp Pro Pro Arg Arg Leu Ala Leu Thr
            260                 265                 270         
Pro Ala His Leu Leu Phe Thr Ala Asp Asn His Thr Glu Pro Ala Ala
        275                 280                 285             
Arg Phe Arg Ala Thr Phe Ala Ser His Val Gln Pro Gly Gln Tyr Val
    290                 295                 300                 
Leu Val Ala Gly Val Pro Gly Leu Gln Pro Ala Arg Val Ala Ala Val
305                 310                 315                 320 
Ser Thr His Val Ala Leu Gly Ala Tyr Ala Pro Leu Thr Lys His Gly
                325                 330                 335     
Thr Leu Val Val Glu Asp Val Val Ala Ser Cys Phe Ala Ala Val Ala
            340                 345                 350         
Asp His His Leu Ala Gln Leu Ala Phe Trp Pro Leu Arg Leu Phe His
        355                 360                 365             
Ser Leu Ala Trp Gly Ser Trp Thr Pro Gly Glu Gly Val His Trp Tyr
    370                 375                 380                 
Pro Gln Leu Leu Tyr Arg Leu Gly Arg Leu Leu Leu Glu Glu Gly Ser
385                 390                 395                 400 
Phe His Pro Leu Gly Met Ser Gly Ala Gly Ser
                405                 410     


<210> 5762
<211> 6339
<212> PRT
<213> Homo sapiens

<400> 5762
Gly Ser Lys Asn Gln Gln Arg Gly Gln Gly Val Arg Thr Gly Val Arg
 1               5                  10                  15      
Gly Arg Ala Arg Val Cys Gly Gly Pro Ala Gly Thr Ala Gly Ser Ala
            20                  25                  30          
Arg Met Ser Val Phe Leu Gly Pro Gly Met Pro Ser Ala Ser Leu Leu
        35                  40                  45              
Val Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe Gly Glu Thr
    50                  55                  60                  
Glu Ile Arg Phe Thr Gly Gln Thr Glu Phe Val Val Asn Glu Thr Ser
65                  70                  75                  80  
Thr Thr Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu Pro Ala Asn
                85                  90                  95      
Val Thr Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly Asp Phe Phe
            100                 105                 110         
Asp Thr Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Thr Asn Arg Thr
        115                 120                 125             
Val Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro Asp Glu Thr
    130                 135                 140                 
Phe Ile Phe His Leu Thr Leu Gln Lys Pro Ser Ala Asn Val Lys Leu
145                 150                 155                 160 
Gly Trp Pro Arg Thr Val Thr Val Thr Ile Leu Ser Asn Asp Asn Ala
                165                 170                 175     
Phe Gly Ile Ile Ser Phe Asn Met Leu Pro Ser Ile Ala Val Ser Glu
            180                 185                 190         
Pro Lys Gly Arg Asn Glu Ser Met Pro Leu Thr Leu Ile Arg Glu Lys
        195                 200                 205             
Gly Thr Tyr Gly Met Val Met Val Thr Phe Glu Val Glu Gly Gly Pro
    210                 215                 220                 
Asn Pro Pro Asp Glu Asp Leu Ser Pro Val Lys Gly Asn Ile Thr Phe
225                 230                 235                 240 
Pro Pro Gly Arg Ala Thr Val Ile Tyr Asn Leu Thr Val Leu Asp Asp
                245                 250                 255     
Glu Val Pro Glu Asn Asp Glu Ile Phe Leu Ile Gln Leu Lys Ser Val
            260                 265                 270         
Glu Gly Gly Ala Glu Ile Asn Thr Ser Arg Asn Ser Ile Glu Ile Ile
        275                 280                 285             
Ile Lys Lys Asn Asp Ser Pro Val Arg Phe Leu Gln Ser Ile Tyr Leu
    290                 295                 300                 
Val Pro Glu Glu Asp His Ile Leu Ile Ile Pro Val Val Arg Gly Lys
305                 310                 315                 320 
Asp Asn Asn Gly Asn Leu Ile Gly Ser Asp Glu Tyr Glu Val Ser Ile
                325                 330                 335     
Ser Tyr Ala Val Thr Thr Gly Asn Ser Thr Ala His Ala Gln Gln Asn
            340                 345                 350         
Leu Asp Phe Ile Asp Leu Gln Pro Asn Thr Thr Val Val Phe Pro Pro
        355                 360                 365             
Phe Ile His Glu Ser His Leu Lys Phe Gln Ile Val Asp Asp Thr Ile
    370                 375                 380                 
Pro Glu Ile Ala Glu Ser Phe His Ile Met Leu Leu Lys Asp Thr Leu
385                 390                 395                 400 
Gln Gly Asp Ala Val Leu Ile Ser Pro Ser Val Val Gln Val Thr Ile
                405                 410                 415     
Lys Pro Asn Asp Lys Pro Tyr Gly Val Leu Ser Phe Asn Ser Val Leu
            420                 425                 430         
Phe Glu Arg Thr Val Ile Ile Asp Glu Asp Arg Ile Ser Arg Tyr Glu
        435                 440                 445             
Glu Ile Thr Val Val Arg Asn Gly Gly Thr His Gly Asn Val Ser Ala
    450                 455                 460                 
Asn Trp Val Leu Thr Arg Asn Ser Thr Asp Pro Ser Pro Val Thr Ala
465                 470                 475                 480 
Asp Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala Gln Gly Gln Met
                485                 490                 495     
Leu Ala Thr Ile Pro Leu Thr Val Val Asp Asp Asp Leu Pro Glu Glu
            500                 505                 510         
Ala Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Thr Ile Arg Gly Gly
        515                 520                 525             
Ala Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr Ile Gln Asp Ser
    530                 535                 540                 
Asp Asp Val Tyr Gly Leu Ile Thr Phe Phe Pro Met Glu Asn Gln Lys
545                 550                 555                 560 
Ile Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu Ser Phe Thr Arg
                565                 570                 575     
Leu Gly Gly Thr Lys Gly Asp Val Arg Leu Leu Tyr Ser Val Leu Tyr
            580                 585                 590         
Ile Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys Glu Gly Ile Leu
        595                 600                 605             
Asn Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu Gln Lys Thr Gln
    610                 615                 620                 
Val Thr Thr Lys Leu Pro Ile Arg Asn Asp Ala Phe Leu Gln Asn Gly
625                 630                 635                 640 
Ala His Phe Leu Val Gln Leu Glu Thr Val Glu Leu Leu Asn Ile Ile
                645                 650                 655     
Pro Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu Ile Cys Asn Ile
            660                 665                 670         
Ser Leu Leu Val Thr Pro Ala Ile Ala Asn Gly Glu Ile Gly Phe Leu
        675                 680                 685             
Ser Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp Phe Ala Ala Glu
    690                 695                 700                 
Val Val Tyr Ile Pro Leu His Arg Asp Gly Thr Asp Gly Gln Ala Thr
705                 710                 715                 720 
Val Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser Lys Ala Val Thr
                725                 730                 735     
Pro Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu Phe Leu Ser Gly
            740                 745                 750         
Gln Ser Asp Thr Thr Ile Asn Ile Thr Ile Lys Gly Asp Asp Ile Pro
        755                 760                 765             
Glu Met Asn Glu Thr Val Thr Leu Ser Leu Asp Arg Val Asn Val Glu
    770                 775                 780                 
Asn Gln Val Leu Lys Ser Gly Tyr Thr Ser Arg Asp Leu Ile Ile Leu
785                 790                 795                 800 
Glu Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser Pro Ala Ser Arg
                805                 810                 815     
Gly Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu Leu His Ile Ile
            820                 825                 830         
Arg Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His Tyr Arg Val Glu
        835                 840                 845             
Pro Arg Asp Ser Asn Glu Phe Tyr Gly Asn Thr Gly Val Leu Glu Phe
    850                 855                 860                 
Lys Pro Gly Glu Arg Glu Ile Val Ile Thr Leu Leu Ala Arg Leu Asp
865                 870                 875                 880 
Gly Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val Leu Ser Ser His
                885                 890                 895     
Gly Glu Arg Glu Ser Lys Leu Gly Ser Ala Thr Ile Val Asn Ile Thr
            900                 905                 910         
Ile Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu Phe Val Ser Asp
        915                 920                 925             
Gly Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser
    930                 935                 940                 
Ala Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser
945                 950                 955                 960 
Val Ser Trp Val Val Ser Pro Asp Phe Thr Gln Asp Val Phe Pro Val
                965                 970                 975     
Gln Gly Thr Val Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Thr
            980                 985                 990         
Ile Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Thr
        995                 1000                1005            
Val Ile Leu Leu Asn Gly Thr Gly Gly Ala Lys Val Gly Asn Arg Thr
    1010                1015                1020                
Thr Ala Thr Leu Arg Ile Arg Arg Asn Asp Asp Pro Ile Tyr Phe Ala
1025                1030                1035                1040
Glu Pro Arg Val Val Arg Val Gln Glu Gly Glu Thr Ala Asn Phe Thr
                1045                1050                1055    
Val Leu Arg Asn Gly Ser Val Asp Val Thr Cys Met Val Gln Tyr Ala
            1060                1065                1070        
Thr Lys Asp Gly Lys Ala Thr Ala Arg Glu Arg Asp Phe Ile Pro Val
        1075                1080                1085            
Glu Lys Gly Glu Thr Leu Ile Phe Glu Val Gly Ser Arg Gln Gln Ser
    1090                1095                1100                
Ile Ser Ile Phe Val Asn Glu Asp Gly Ile Pro Glu Thr Asp Glu Pro
1105                1110                1115                1120
Phe Tyr Ile Ile Leu Leu Asn Ser Thr Gly Asp Thr Val Val Tyr Gln
                1125                1130                1135    
Tyr Gly Val Ala Thr Val Ile Ile Glu Ala Asn Asp Asp Pro Asn Gly
            1140                1145                1150        
Ile Phe Ser Leu Glu Pro Ile Asp Lys Ala Val Glu Glu Gly Lys Thr
        1155                1160                1165            
Asn Ala Phe Trp Ile Leu Arg His Arg Gly Tyr Phe Gly Ser Val Ser
    1170                1175                1180                
Val Ser Trp Gln Leu Phe Gln Asn Asp Ser Ala Leu Gln Pro Gly Gln
1185                1190                1195                1200
Glu Phe Tyr Glu Thr Ser Gly Thr Val Asn Phe Met Asp Gly Glu Glu
                1205                1210                1215    
Ala Lys Pro Ile Ile Leu His Ala Phe Pro Asp Lys Ile Pro Glu Phe
            1220                1225                1230        
Asn Glu Phe Tyr Phe Leu Lys Leu Val Asn Ile Ser Gly Gly Ser Pro
        1235                1240                1245            
Gly Pro Gly Gly Gln Leu Ala Glu Thr Asn Leu Gln Val Thr Val Met
    1250                1255                1260                
Val Pro Phe Asn Asp Asp Pro Phe Gly Val Phe Ile Leu Asp Pro Glu
1265                1270                1275                1280
Cys Leu Glu Arg Glu Val Ala Glu Asp Val Leu Ser Glu Asp Asp Met
                1285                1290                1295    
Ser Tyr Ile Thr Asn Phe Thr Ile Leu Arg Gln Gln Gly Val Phe Gly
            1300                1305                1310        
Asp Val Gln Leu Gly Trp Glu Ile Leu Ser Ser Glu Phe Pro Ala Gly
        1315                1320                1325            
Leu Pro Pro Met Ile Asp Phe Leu Leu Val Gly Ile Phe Pro Thr Thr
    1330                1335                1340                
Val His Leu Gln Gln His Met Arg Arg His His Ser Gly Thr Asp Ala
1345                1350                1355                1360
Leu Tyr Phe Thr Gly Leu Glu Gly Ala Phe Gly Thr Val Asn Pro Lys
                1365                1370                1375    
Tyr His Pro Ser Arg Asn Asn Thr Ile Ala Asn Phe Thr Phe Ser Ala
            1380                1385                1390        
Trp Val Met Pro Asn Ala Asn Thr Asn Gly Phe Ile Ile Ala Lys Asp
        1395                1400                1405            
Asp Gly Asn Gly Ser Ile Tyr Tyr Gly Val Lys Ile Gln Thr Asn Glu
    1410                1415                1420                
Ser His Val Thr Leu Ser Leu His Tyr Lys Thr Leu Gly Ser Asn Ala
1425                1430                1435                1440
Thr Tyr Ile Ala Lys Thr Thr Val Met Lys Tyr Leu Glu Glu Ser Val
                1445                1450                1455    
Trp Leu His Leu Leu Ile Ile Leu Glu Asp Gly Ile Ile Glu Phe Tyr
            1460                1465                1470        
Leu Asp Gly Asn Ala Met Pro Arg Gly Ile Lys Ser Leu Lys Gly Glu
        1475                1480                1485            
Ala Ile Thr Asp Gly Pro Gly Ile Leu Arg Ile Gly Ala Gly Ile Asn
    1490                1495                1500                
Gly Asn Asp Arg Phe Thr Gly Leu Met Gln Asp Val Arg Ser Tyr Glu
1505                1510                1515                1520
Arg Lys Leu Thr Leu Glu Glu Ile Tyr Glu Leu His Ala Met Pro Ala
                1525                1530                1535    
Lys Ser Asp Leu His Pro Ile Ser Gly Tyr Leu Glu Phe Arg Gln Gly
            1540                1545                1550        
Glu Thr Asn Lys Ser Phe Ile Ile Ser Ala Arg Asp Asp Asn Asp Glu
        1555                1560                1565            
Glu Gly Glu Glu Leu Phe Ile Leu Lys Leu Val Ser Val Tyr Gly Gly
    1570                1575                1580                
Ala Arg Ile Ser Glu Glu Asn Thr Thr Ala Arg Leu Thr Ile Gln Lys
1585                1590                1595                1600
Ser Asp Asn Ala Asn Gly Leu Phe Gly Phe Thr Gly Ala Cys Ile Pro
                1605                1610                1615    
Glu Ile Ala Glu Glu Gly Ser Thr Ile Ser Cys Val Val Glu Arg Thr
            1620                1625                1630        
Arg Gly Ala Leu Asp Tyr Val His Val Phe Tyr Thr Ile Ser Gln Ile
        1635                1640                1645            
Glu Thr Asp Gly Ile Asn Tyr Leu Val Asp Asp Phe Ala Asn Ala Ser
    1650                1655                1660                
Gly Thr Ile Thr Phe Leu Pro Trp Gln Arg Ser Glu Val Leu Asn Ile
1665                1670                1675                1680
Tyr Val Leu Asp Asp Asp Ile Pro Glu Leu Asn Glu Tyr Phe Arg Val
                1685                1690                1695    
Thr Leu Val Ser Ala Ile Pro Gly Asp Gly Lys Leu Gly Ser Thr Pro
            1700                1705                1710        
Thr Ser Gly Ala Ser Ile Asp Pro Glu Lys Glu Thr Thr Asp Ile Thr
        1715                1720                1725            
Ile Lys Ala Ser Asp His Pro Tyr Gly Leu Leu Gln Phe Ser Thr Gly
    1730                1735                1740                
Leu Pro Pro Gln Pro Lys Asp Ala Met Thr Leu Pro Ala Ser Ser Val
1745                1750                1755                1760
Pro His Ile Thr Val Glu Glu Glu Asp Gly Glu Ile Arg Leu Leu Val
                1765                1770                1775    
Ile Arg Ala Gln Gly Leu Leu Gly Arg Val Thr Ala Glu Phe Arg Thr
            1780                1785                1790        
Val Ser Leu Thr Ala Phe Ser Pro Glu Asp Tyr Gln Asn Val Ala Gly
        1795                1800                1805            
Thr Leu Glu Phe Gln Pro Gly Glu Arg Tyr Lys Tyr Ile Phe Ile Asn
    1810                1815                1820                
Ile Thr Asp Asn Ser Ile Pro Glu Leu Glu Lys Ser Phe Lys Val Glu
1825                1830                1835                1840
Leu Leu Asn Leu Glu Gly Gly Val Ala Glu Leu Phe Arg Val Asp Gly
                1845                1850                1855    
Ser Gly Ser Gly Asp Gly Asp Met Glu Phe Phe Leu Pro Thr Ile His
            1860                1865                1870        
Lys Arg Ala Ser Leu Gly Val Ala Ser Gln Ile Leu Val Thr Ile Ala
        1875                1880                1885            
Ala Ser Asp His Ala His Gly Val Phe Glu Phe Ser Pro Glu Ser Leu
    1890                1895                1900                
Phe Val Ser Gly Thr Glu Pro Glu Asp Gly Tyr Ser Thr Val Thr Leu
1905                1910                1915                1920
Asn Val Ile Arg His His Gly Thr Leu Ser Pro Val Thr Leu His Trp
                1925                1930                1935    
Asn Ile Asp Ser Asp Pro Asp Gly Asp Leu Ala Phe Thr Ser Gly Asn
            1940                1945                1950        
Ile Thr Phe Glu Ile Gly Gln Thr Ser Ala Asn Ile Thr Val Glu Ile
        1955                1960                1965            
Leu Pro Asp Glu Asp Pro Glu Leu Asp Lys Ala Phe Ser Val Ser Val
    1970                1975                1980                
Leu Ser Val Ser Ser Gly Ser Leu Gly Ala His Ile Asn Ala Thr Leu
1985                1990                1995                2000
Thr Val Leu Ala Ser Asp Asp Pro Tyr Gly Ile Phe Ile Phe Ser Glu
                2005                2010                2015    
Lys Asn Arg Pro Val Lys Val Glu Glu Ala Thr Gln Asn Ile Thr Leu
            2020                2025                2030        
Ser Ile Ile Arg Leu Lys Gly Leu Met Gly Lys Val Leu Val Ser Tyr
        2035                2040                2045            
Ala Thr Leu Asp Asp Met Glu Lys Pro Pro Tyr Phe Pro Pro Asn Leu
    2050                2055                2060                
Ala Arg Ala Thr Gln Gly Arg Asp Tyr Ile Pro Ala Ser Gly Phe Ala
2065                2070                2075                2080
Leu Phe Gly Ala Asn Gln Ser Glu Ala Thr Ile Ala Ile Ser Ile Leu
                2085                2090                2095    
Asp Asp Asp Glu Pro Glu Arg Ser Glu Ser Val Phe Ile Glu Leu Leu
            2100                2105                2110        
Asn Ser Thr Leu Val Ala Lys Val Gln Ser Arg Ser Ile Pro Asn Ser
        2115                2120                2125            
Pro Arg Leu Gly Pro Lys Val Glu Thr Ile Ala Gln Leu Ile Ile Ile
    2130                2135                2140                
Ala Asn Asp Asp Ala Phe Gly Thr Leu Gln Leu Ser Ala Pro Ile Val
2145                2150                2155                2160
Arg Val Ala Glu Asn His Val Gly Pro Ile Ile Asn Val Thr Arg Thr
                2165                2170                2175    
Gly Gly Ala Phe Ala Asp Val Ser Val Lys Phe Lys Ala Val Pro Ile
            2180                2185                2190        
Thr Ala Ile Ala Gly Glu Asp Tyr Ser Ile Ala Ser Ser Asp Val Val
        2195                2200                2205            
Leu Leu Glu Gly Glu Thr Ser Lys Ala Val Pro Ile Tyr Val Ile Asn
    2210                2215                2220                
Asp Ile Tyr Pro Glu Leu Glu Glu Ser Phe Leu Val Gln Leu Met Asn
2225                2230                2235                2240
Glu Thr Thr Gly Gly Ala Arg Leu Gly Ala Leu Thr Glu Ala Val Ile
                2245                2250                2255    
Ile Ile Glu Ala Ser Asp Asp Pro Tyr Gly Leu Phe Gly Phe Gln Ile
            2260                2265                2270        
Thr Lys Leu Ile Val Glu Glu Pro Glu Phe Asn Ser Val Lys Val Asn
        2275                2280                2285            
Leu Pro Ile Ile Arg Asn Ser Gly Thr Leu Gly Asn Val Thr Val Gln
    2290                2295                2300                
Trp Val Ala Thr Ile Asn Gly Gln Leu Ala Thr Gly Asp Leu Arg Val
2305                2310                2315                2320
Val Ser Gly Asn Val Thr Phe Ala Pro Gly Glu Thr Ile Gln Thr Leu
                2325                2330                2335    
Leu Leu Glu Val Leu Ala Asp Asp Val Pro Glu Ile Glu Glu Val Ile
            2340                2345                2350        
Gln Val Gln Leu Thr Asp Ala Ser Gly Gly Gly Thr Ile Gly Leu Asp
        2355                2360                2365            
Arg Ile Ala Asn Ile Ile Ile Pro Ala Asn Asp Asp Pro Tyr Gly Thr
    2370                2375                2380                
Val Ala Phe Ala Gln Met Val Tyr Arg Val Gln Glu Pro Leu Glu Arg
2385                2390                2395                2400
Ser Ser Cys Ala Asn Ile Thr Val Arg Arg Ser Gly Gly His Phe Gly
                2405                2410                2415    
Arg Leu Leu Leu Phe Tyr Ser Thr Ser Asp Ile Asp Val Val Ala Leu
            2420                2425                2430        
Ala Met Glu Glu Gly Gln Asp Leu Leu Ser Tyr Tyr Glu Ser Pro Ile
        2435                2440                2445            
Gln Gly Val Pro Asp Pro Leu Trp Arg Thr Trp Met Asn Val Ser Ala
    2450                2455                2460                
Val Gly Glu Pro Leu Tyr Thr Cys Ala Thr Leu Cys Leu Lys Glu Gln
2465                2470                2475                2480
Ala Cys Ser Ala Phe Ser Phe Phe Ser Ala Ser Glu Gly Pro Gln Cys
                2485                2490                2495    
Phe Trp Met Thr Ser Trp Ile Ser Pro Ala Val Asn Asn Ser Asp Phe
            2500                2505                2510        
Trp Thr Tyr Arg Lys Asn Met Thr Arg Val Ala Ser Leu Phe Ser Gly
        2515                2520                2525            
Gln Ala Val Ala Gly Ser Asp Tyr Glu Pro Val Thr Arg Gln Trp Ala
    2530                2535                2540                
Ile Met Gln Glu Gly Asp Glu Phe Ala Asn Leu Thr Val Ser Ile Leu
2545                2550                2555                2560
Pro Asp Asp Phe Pro Glu Met Asp Glu Ser Phe Leu Ile Ser Leu Leu
                2565                2570                2575    
Glu Val His Leu Met Asn Ile Ser Ala Ser Leu Lys Asn Gln Pro Thr
            2580                2585                2590        
Ile Gly Gln Pro Asn Ile Ser Thr Val Val Ile Ala Leu Asn Gly Asp
        2595                2600                2605            
Ala Phe Gly Val Phe Val Ile Tyr Asn Ile Ser Pro Asn Thr Ser Glu
    2610                2615                2620                
Asp Gly Leu Phe Val Glu Val Gln Glu Gln Pro Gln Thr Leu Val Glu
2625                2630                2635                2640
Leu Met Ile His Arg Thr Gly Gly Ser Leu Gly Gln Val Ala Val Glu
                2645                2650                2655    
Trp Arg Val Val Gly Gly Thr Ala Thr Glu Gly Leu Asp Phe Ile Gly
            2660                2665                2670        
Ala Gly Glu Ile Leu Thr Phe Ala Glu Gly Glu Thr Lys Lys Thr Val
        2675                2680                2685            
Ile Leu Thr Ile Leu Asp Asp Ser Glu Pro Glu Asp Asp Glu Ser Ile
    2690                2695                2700                
Ile Val Ser Leu Val Tyr Thr Glu Gly Gly Ser Arg Ile Leu Pro Ser
2705                2710                2715                2720
Ser Asp Thr Val Arg Val Asn Ile Leu Ala Asn Asp Asn Val Ala Gly
                2725                2730                2735    
Ile Val Ser Phe Gln Thr Ala Ser Arg Ser Val Ile Gly His Glu Gly
            2740                2745                2750        
Glu Ile Leu Gln Phe His Val Ile Arg Thr Phe Pro Gly Arg Gly Asn
        2755                2760                2765            
Val Thr Val Asn Trp Lys Ile Ile Gly Gln Asn Leu Glu Leu Asn Phe
    2770                2775                2780                
Ala Asn Phe Ser Gly Gln Leu Phe Phe Pro Glu Gly Ser Leu Asn Thr
2785                2790                2795                2800
Thr Leu Phe Val His Leu Leu Asp Asp Asn Ile Pro Glu Glu Lys Glu
                2805                2810                2815    
Val Tyr Gln Val Ile Leu Tyr Asp Val Arg Thr Gln Gly Val Pro Pro
            2820                2825                2830        
Ala Gly Ile Ala Leu Leu Asp Ala Gln Gly Tyr Ala Ala Val Leu Thr
        2835                2840                2845            
Val Glu Ala Ser Asp Glu Pro His Gly Val Leu Asn Phe Ala Leu Ser
    2850                2855                2860                
Ser Arg Phe Val Leu Leu Gln Glu Ala Asn Ile Thr Ile Gln Leu Phe
2865                2870                2875                2880
Ile Asn Arg Glu Phe Gly Ser Leu Gly Ala Ile Asn Val Thr Tyr Thr
                2885                2890                2895    
Thr Val Pro Gly Met Leu Ser Leu Lys Asn Gln Thr Val Gly Asn Leu
            2900                2905                2910        
Ala Glu Pro Glu Val Asp Phe Val Pro Ile Ile Gly Phe Leu Ile Leu
        2915                2920                2925            
Glu Glu Gly Glu Thr Ala Ala Ala Ile Asn Ile Thr Ile Leu Glu Asp
    2930                2935                2940                
Asp Val Pro Glu Leu Glu Glu Tyr Phe Leu Val Asn Leu Thr Tyr Val
2945                2950                2955                2960
Gly Leu Thr Met Ala Ala Ser Thr Ser Phe Pro Pro Arg Leu Asp Ser
                2965                2970                2975    
Glu Gly Leu Thr Ala Gln Val Ile Ile Asp Ala Asn Asp Gly Ala Arg
            2980                2985                2990        
Gly Val Ile Glu Trp Gln Gln Ser Arg Phe Glu Val Asn Glu Thr His
        2995                3000                3005            
Gly Ser Leu Thr Leu Val Ala Gln Arg Ser Arg Glu Pro Leu Gly His
    3010                3015                3020                
Val Ser Leu Phe Val Tyr Ala Gln Asn Leu Glu Ala Gln Val Gly Leu
3025                3030                3035                3040
Asp Tyr Ile Phe Thr Pro Met Ile Leu His Phe Ala Asp Gly Glu Arg
                3045                3050                3055    
Tyr Lys Asn Val Asn Ile Met Ile Leu Asp Asp Asp Ile Pro Glu Gly
            3060                3065                3070        
Asp Glu Lys Phe Gln Leu Ile Leu Thr Asn Pro Ser Pro Gly Leu Glu
        3075                3080                3085            
Leu Gly Lys Asn Thr Ile Ala Leu Ile Ile Val Leu Ala Asn Asp Asp
    3090                3095                3100                
Gly Pro Gly Val Leu Ser Phe Asn Asn Ser Glu His Phe Phe Leu Arg
3105                3110                3115                3120
Glu Pro Thr Ala Leu Tyr Val Gln Glu Ser Val Ala Val Leu Tyr Ile
                3125                3130                3135    
Val Arg Glu Pro Ala Gln Gly Leu Phe Gly Thr Val Thr Val Gln Phe
            3140                3145                3150        
Ile Val Thr Glu Val Asn Ser Ser Asn Glu Ser Lys Asp Leu Thr Pro
        3155                3160                3165            
Ser Lys Gly Tyr Ile Val Leu Glu Glu Gly Val Arg Phe Lys Ala Leu
    3170                3175                3180                
Gln Ile Ser Ala Ile Leu Asp Thr Glu Pro Glu Met Asp Glu Tyr Phe
3185                3190                3195                3200
Val Cys Thr Leu Phe Asn Pro Thr Gly Gly Ala Arg Leu Gly Val His
                3205                3210                3215    
Val Gln Thr Leu Ile Thr Val Leu Gln Asn Gln Ala Pro Leu Gly Leu
            3220                3225                3230        
Phe Ser Ile Ser Ala Val Glu Asn Arg Ala Thr Ser Ile Asp Ile Glu
        3235                3240                3245            
Glu Ala Asn Arg Thr Val Tyr Leu Asn Val Ser Arg Thr Asn Gly Ile
    3250                3255                3260                
Asp Leu Ala Val Ser Val Gln Trp Glu Thr Val Ser Glu Thr Ala Phe
3265                3270                3275                3280
Gly Met Arg Gly Met Asp Val Val Phe Ser Val Phe Gln Ser Phe Leu
                3285                3290                3295    
Asp Glu Ser Ala Ser Gly Trp Cys Phe Phe Thr Leu Glu Asn Leu Ile
            3300                3305                3310        
Tyr Gly Ile Met Leu Arg Lys Ser Ser Val Thr Val Tyr Arg Trp Gln
        3315                3320                3325            
Gly Ile Phe Ile Pro Val Glu Asp Leu Asn Ile Glu Asn Pro Lys Thr
    3330                3335                3340                
Cys Glu Ala Phe Asn Ile Gly Phe Ser Pro Tyr Phe Val Ile Thr His
3345                3350                3355                3360
Glu Glu Arg Asn Glu Glu Lys Pro Ser Leu Asn Ser Val Phe Thr Phe
                3365                3370                3375    
Thr Ser Gly Phe Lys Leu Phe Leu Val Gln Thr Ile Ile Ile Leu Glu
            3380                3385                3390        
Ser Ser Gln Val Arg Tyr Phe Thr Ser Asp Ser Gln Asp Tyr Leu Ile
        3395                3400                3405            
Ile Ala Ser Gln Arg Asp Asp Ser Glu Leu Thr Gln Val Phe Arg Trp
    3410                3415                3420                
Asn Gly Gly Ser Phe Val Leu His Gln Lys Leu Pro Val Arg Gly Val
3425                3430                3435                3440
Leu Thr Val Ala Leu Phe Asn Lys Gly Gly Ser Val Phe Leu Ala Ile
                3445                3450                3455    
Ser Gln Ala Asn Ala Arg Leu Asn Ser Leu Leu Phe Arg Trp Ser Gly
            3460                3465                3470        
Ser Gly Phe Ile Asn Phe Gln Glu Val Pro Val Ser Gly Thr Thr Glu
        3475                3480                3485            
Val Glu Ala Leu Ser Ser Ala Asn Asp Ile Tyr Leu Ile Phe Ala Glu
    3490                3495                3500                
Asn Val Phe Leu Gly Asp Gln Asn Ser Ile Asp Ile Phe Ile Trp Glu
3505                3510                3515                3520
Met Gly Gln Ser Ser Phe Arg Tyr Phe Gln Ser Val Asp Phe Ala Ala
                3525                3530                3535    
Val Asn Arg Ile His Ser Phe Thr Pro Ala Ser Gly Ile Ala His Ile
            3540                3545                3550        
Leu Leu Ile Gly Gln Asp Met Ser Ala Leu Tyr Cys Trp Asn Ser Glu
        3555                3560                3565            
Arg Asn Gln Phe Ser Phe Val Leu Glu Val Pro Ser Ala Tyr Asp Val
    3570                3575                3580                
Ala Ser Val Thr Val Lys Ser Leu Asn Ser Ser Lys Asn Leu Ile Ala
3585                3590                3595                3600
Leu Val Gly Ala His Ser His Ile Tyr Glu Leu Ala Tyr Ile Ser Ser
                3605                3610                3615    
His Ser Asp Phe Ile Pro Ser Ser Gly Glu Leu Ile Phe Glu Pro Gly
            3620                3625                3630        
Glu Arg Glu Ala Thr Ile Ala Val Asn Ile Leu Asp Asp Thr Val Pro
        3635                3640                3645            
Glu Lys Glu Glu Ser Phe Lys Val Gln Leu Lys Asn Pro Lys Gly Gly
    3650                3655                3660                
Ala Glu Ile Gly Ile Asn Asp Ser Val Thr Ile Thr Ile Leu Ser Asn
3665                3670                3675                3680
Asp Asp Ala Tyr Gly Ile Val Ala Phe Ala Gln Asn Ser Leu Tyr Lys
                3685                3690                3695    
Gln Val Glu Glu Met Glu Gln Asp Ser Leu Val Thr Leu Asn Val Glu
            3700                3705                3710        
Arg Leu Lys Gly Thr Tyr Gly Arg Ile Thr Ile Ala Trp Glu Ala Asp
        3715                3720                3725            
Gly Ser Ile Ser Asp Ile Phe Pro Thr Ser Gly Val Ile Leu Phe Thr
    3730                3735                3740                
Glu Gly Gln Val Leu Ser Thr Ile Thr Leu Thr Ile Leu Ala Asp Asn
3745                3750                3755                3760
Ile Pro Glu Leu Ser Glu Val Val Ile Val Thr Leu Thr Arg Ile Thr
                3765                3770                3775    
Thr Glu Gly Val Glu Asp Ser Tyr Lys Gly Ala Thr Ile Asp Gln Asp
            3780                3785                3790        
Arg Ser Lys Ser Val Ile Thr Thr Leu Pro Asn Asp Ser Pro Phe Gly
        3795                3800                3805            
Leu Val Gly Trp Arg Ala Ala Ser Val Phe Ile Arg Val Ala Glu Pro
    3810                3815                3820                
Lys Glu Asn Thr Thr Thr Leu Gln Leu Gln Ile Ala Arg Asp Lys Gly
3825                3830                3835                3840
Leu Leu Gly Asp Ile Ala Ile His Leu Arg Ala Gln Pro Asn Phe Leu
                3845                3850                3855    
Leu His Val Asp Asn Gln Ala Thr Glu Asn Glu Asp Tyr Val Leu Gln
            3860                3865                3870        
Glu Thr Ile Ile Ile Met Lys Glu Asn Ile Lys Glu Ala His Ala Glu
        3875                3880                3885            
Val Ser Ile Leu Pro Asp Asp Leu Pro Glu Leu Glu Glu Gly Phe Ile
    3890                3895                3900                
Val Thr Ile Thr Glu Val Asn Leu Val Asn Ser Asp Phe Ser Thr Gly
3905                3910                3915                3920
Gln Pro Ser Val Arg Arg Pro Gly Met Glu Ile Ala Glu Ile Met Ile
                3925                3930                3935    
Glu Glu Asn Asp Asp Pro Arg Gly Ile Phe Met Phe His Val Thr Arg
            3940                3945                3950        
Gly Ala Gly Glu Val Ile Thr Ala Tyr Glu Val Pro Pro Pro Leu Asn
        3955                3960                3965            
Val Leu Gln Val Pro Val Val Arg Leu Ala Gly Ser Phe Gly Ala Val
    3970                3975                3980                
Asn Val Tyr Trp Lys Ala Ser Pro Asp Ser Ala Gly Leu Glu Asp Phe
3985                3990                3995                4000
Lys Pro Ser His Gly Ile Leu Glu Phe Ala Asp Lys Gln Val Thr Ala
                4005                4010                4015    
Met Ile Glu Ile Thr Ile Ile Asp Asp Ala Glu Phe Glu Leu Thr Glu
            4020                4025                4030        
Thr Phe Asn Ile Ser Leu Ile Ser Val Ala Gly Gly Gly Arg Leu Gly
        4035                4040                4045            
Asp Asp Val Val Val Thr Val Val Ile Pro Gln Asn Asp Ser Pro Phe
    4050                4055                4060                
Gly Val Phe Gly Phe Glu Glu Lys Thr Val Met Ile Asp Glu Ser Leu
4065                4070                4075                4080
Ser Ser Asp Asp Pro Asp Ser Tyr Val Thr Leu Thr Val Val Arg Ser
                4085                4090                4095    
Pro Gly Gly Lys Gly Thr Val Arg Leu Glu Trp Thr Ile Asp Glu Lys
            4100                4105                4110        
Ala Lys His Asn Leu Ser Pro Leu Asn Gly Thr Leu His Phe Asp Glu
        4115                4120                4125            
Thr Glu Ser Gln Lys Thr Ile Val Leu His Thr Leu Gln Asp Thr Val
    4130                4135                4140                
Leu Glu Glu Asp Arg Arg Phe Thr Ile Gln Leu Ile Ser Ile Asp Glu
4145                4150                4155                4160
Val Glu Ile Ser Pro Val Lys Gly Ser Ala Ser Ile Ile Ile Arg Gly
                4165                4170                4175    
Asp Lys Arg Ala Ser Gly Glu Val Gly Ile Ala Pro Ser Ser Arg His
            4180                4185                4190        
Ile Leu Ile Gly Glu Pro Ser Ala Lys Tyr Asn Gly Thr Ala Ile Ile
        4195                4200                4205            
Ser Leu Val Arg Gly Pro Gly Ile Leu Gly Glu Val Thr Val Phe Trp
    4210                4215                4220                
Arg Ile Phe Pro Pro Ser Val Gly Glu Phe Ala Glu Thr Ser Gly Lys
4225                4230                4235                4240
Leu Thr Met Arg Asp Glu Gln Ser Ala Val Ile Val Val Ile Gln Ala
                4245                4250                4255    
Leu Asn Asp Asp Ile Pro Glu Glu Lys Ser Phe Tyr Glu Phe Gln Leu
            4260                4265                4270        
Thr Ala Val Ser Glu Gly Gly Val Leu Ser Glu Ser Ser Ser Thr Ala
        4275                4280                4285            
Asn Ile Thr Val Val Ala Ser Asp Ser Pro Tyr Gly Arg Phe Ala Phe
    4290                4295                4300                
Ser His Glu Gln Leu Arg Val Ser Glu Ala Gln Arg Val Asn Ile Thr
4305                4310                4315                4320
Ile Ile Arg Ser Ser Gly Asp Phe Gly His Val Arg Leu Trp Tyr Lys
                4325                4330                4335    
Thr Met Ser Gly Thr Ala Glu Ala Gly Leu Asp Phe Val Pro Ala Ala
            4340                4345                4350        
Gly Glu Leu Leu Phe Glu Ala Gly Glu Met Arg Lys Ser Leu His Val
        4355                4360                4365            
Glu Ile Leu Asp Asp Asp Tyr Pro Glu Gly Pro Glu Glu Phe Ser Leu
    4370                4375                4380                
Thr Ile Thr Lys Val Glu Leu Gln Gly Arg Gly Tyr Asp Phe Thr Ile
4385                4390                4395                4400
Gln Glu Asn Gly Leu Gln Ile Asp Gln Pro Pro Glu Ile Gly Asn Ile
                4405                4410                4415    
Ser Ile Val Arg Ile Ile Ile Met Lys Asn Asp Asn Ala Glu Gly Ile
            4420                4425                4430        
Ile Glu Phe Asp Pro Lys Tyr Thr Ala Phe Glu Val Glu Glu Asp Val
        4435                4440                4445            
Gly Leu Ile Met Ile Pro Val Val Arg Leu His Gly Thr Tyr Gly Tyr
    4450                4455                4460                
Val Thr Ala Asp Phe Ile Ser Gln Ser Ser Ser Ala Ser Pro Gly Gly
4465                4470                4475                4480
Val Asp Tyr Ile Leu His Gly Ser Thr Val Thr Phe Gln His Gly Gln
                4485                4490                4495    
Asn Leu Ser Phe Ile Asn Ile Ser Ile Ile Asp Asp Asn Glu Ser Glu
            4500                4505                4510        
Phe Glu Glu Pro Ile Glu Ile Leu Leu Thr Gly Ala Thr Gly Gly Ala
        4515                4520                4525            
Val Leu Gly Arg His Leu Val Ser Arg Ile Ile Ile Ala Lys Ser Asp
    4530                4535                4540                
Ser Pro Phe Gly Val Ile Arg Phe Leu Asn Gln Ser Lys Ile Ser Ile
4545                4550                4555                4560
Ala Asn Pro Asn Ser Thr Met Ile Leu Ser Leu Val Leu Glu Arg Thr
                4565                4570                4575    
Gly Gly Leu Leu Gly Glu Ile Gln Val Asn Trp Glu Thr Val Gly Pro
            4580                4585                4590        
Asn Ser Gln Glu Ala Leu Leu Pro Gln Asn Arg Asp Ile Ala Asp Pro
        4595                4600                4605            
Val Ser Gly Leu Phe Tyr Phe Gly Glu Gly Glu Gly Gly Val Arg Thr
    4610                4615                4620                
Ile Ile Leu Thr Ile Tyr Pro His Glu Glu Ile Glu Val Glu Glu Thr
4625                4630                4635                4640
Phe Ile Ile Lys Leu His Leu Val Lys Gly Glu Ala Lys Leu Asp Ser
                4645                4650                4655    
Arg Ala Lys Asp Val Thr Leu Thr Ile Gln Glu Phe Gly Asp Pro Asn
            4660                4665                4670        
Gly Val Val Gln Phe Ala Pro Glu Thr Leu Ser Lys Lys Thr Tyr Ser
        4675                4680                4685            
Glu Pro Leu Ala Leu Glu Gly Pro Leu Leu Ile Thr Phe Phe Val Arg
    4690                4695                4700                
Arg Val Lys Gly Thr Phe Gly Glu Ile Met Val Tyr Trp Glu Leu Ser
4705                4710                4715                4720
Ser Glu Phe Asp Ile Thr Glu Asp Phe Leu Ser Thr Ser Gly Phe Phe
                4725                4730                4735    
Thr Ile Ala Asp Gly Glu Ser Glu Ala Ser Phe Asp Val His Leu Leu
            4740                4745                4750        
Pro Asp Glu Val Pro Glu Ile Glu Glu Asp Tyr Val Ile Gln Leu Val
        4755                4760                4765            
Ser Val Glu Gly Gly Ala Glu Leu Asp Leu Glu Lys Ser Ile Thr Trp
    4770                4775                4780                
Phe Ser Val Tyr Ala Asn Asp Asp Pro His Gly Val Phe Ala Leu Tyr
4785                4790                4795                4800
Ser Asp Arg Gln Ser Ile Leu Ile Gly Gln Asn Leu Ile Arg Ser Ile
                4805                4810                4815    
Gln Ile Asn Ile Thr Arg Leu Ala Gly Thr Phe Gly Asp Val Ala Val
            4820                4825                4830        
Gly Leu Arg Ile Ser Ser Asp His Lys Glu Gln Pro Ile Val Thr Glu
        4835                4840                4845            
Asn Ala Glu Arg Gln Leu Val Val Lys Asp Gly Ala Thr Tyr Lys Val
    4850                4855                4860                
Asp Val Val Pro Ile Lys Asn Gln Val Phe Leu Ser Leu Gly Ser Asn
4865                4870                4875                4880
Phe Thr Leu Gln Leu Val Thr Val Met Leu Val Gly Gly Arg Phe Tyr
                4885                4890                4895    
Gly Met Pro Thr Ile Leu Gln Glu Ala Lys Ser Ala Val Leu Pro Val
            4900                4905                4910        
Ser Glu Lys Ala Ala Asn Ser Gln Val Gly Phe Glu Ser Thr Ala Phe
        4915                4920                4925            
Gln Leu Met Asn Ile Thr Ala Gly Thr Ser His Val Met Ile Ser Arg
    4930                4935                4940                
Arg Gly Thr Tyr Gly Ala Leu Ser Val Ala Trp Thr Thr Gly Tyr Ala
4945                4950                4955                4960
Pro Gly Leu Glu Ile Pro Glu Phe Ile Val Val Gly Asn Met Thr Pro
                4965                4970                4975    
Thr Leu Gly Ser Leu Ser Phe Ser His Gly Glu Gln Arg Lys Gly Val
            4980                4985                4990        
Phe Leu Trp Thr Phe Pro Ser Pro Gly Trp Pro Glu Ala Phe Val Leu
        4995                5000                5005            
His Leu Ser Gly Val Gln Ser Ser Ala Pro Gly Gly Ala Gln Leu Arg
    5010                5015                5020                
Ser Gly Phe Ile Val Ala Glu Ile Glu Pro Met Gly Val Phe Gln Phe
5025                5030                5035                5040
Ser Thr Ser Ser Arg Asn Ile Ile Val Ser Glu Asp Thr Gln Met Ile
                5045                5050                5055    
Arg Leu His Val Gln Arg Leu Phe Gly Phe His Ser Asp Leu Ile Lys
            5060                5065                5070        
Val Ser Tyr Gln Thr Thr Ala Gly Ser Ala Lys Pro Leu Glu Asp Phe
        5075                5080                5085            
Glu Pro Val Gln Asn Gly Glu Leu Phe Phe Gln Lys Phe Gln Thr Glu
    5090                5095                5100                
Val Asp Phe Glu Ile Thr Ile Ile Asn Asp Gln Leu Ser Glu Ile Glu
5105                5110                5115                5120
Glu Phe Phe Tyr Ile Asn Leu Thr Ser Val Glu Ile Arg Gly Leu Gln
                5125                5130                5135    
Lys Phe Asp Val Asn Trp Ser Pro Arg Leu Asn Leu Asp Phe Ser Val
            5140                5145                5150        
Ala Val Ile Thr Ile Leu Asp Asn Asp Asp Leu Ala Gly Met Asp Ile
        5155                5160                5165            
Ser Phe Pro Glu Thr Thr Val Ala Val Ala Val Asp Thr Thr Leu Ile
    5170                5175                5180                
Pro Val Glu Thr Glu Ser Thr Thr Tyr Leu Ser Thr Ser Lys Thr Thr
5185                5190                5195                5200
Thr Ile Leu Gln Pro Thr Asn Val Val Ala Ile Val Thr Glu Ala Thr
                5205                5210                5215    
Gly Val Ser Ala Ile Pro Glu Lys Leu Val Thr Leu His Gly Thr Pro
            5220                5225                5230        
Ala Val Ser Glu Lys Pro Asp Val Ala Thr Val Thr Ala Asn Val Ser
        5235                5240                5245            
Ile His Gly Thr Phe Ser Leu Gly Pro Ser Ile Val Tyr Ile Glu Glu
    5250                5255                5260                
Glu Met Lys Asn Gly Thr Phe Asn Thr Ala Glu Val Leu Ile Arg Arg
5265                5270                5275                5280
Thr Gly Gly Phe Thr Gly Asn Val Ser Ile Thr Val Lys Thr Phe Gly
                5285                5290                5295    
Glu Arg Cys Ala Gln Met Glu Pro Asn Ala Leu Pro Phe Arg Gly Ile
            5300                5305                5310        
Tyr Gly Ile Ser Asn Leu Thr Trp Ala Val Glu Glu Glu Asp Phe Glu
        5315                5320                5325            
Glu Gln Thr Leu Thr Leu Ile Phe Leu Asp Gly Glu Arg Glu Arg Lys
    5330                5335                5340                
Val Ser Val Gln Ile Leu Asp Asp Asp Glu Pro Glu Gly Gln Glu Phe
5345                5350                5355                5360
Phe Tyr Val Phe Leu Thr Asn Pro Gln Gly Gly Ala Gln Ile Val Glu
                5365                5370                5375    
Glu Lys Asp Asp Thr Gly Phe Ala Ala Phe Ala Met Val Ile Ile Thr
            5380                5385                5390        
Gly Ser Asp Leu His Asn Gly Ile Ile Gly Phe Ser Glu Glu Ser Gln
        5395                5400                5405            
Ser Gly Leu Glu Leu Arg Glu Gly Ala Val Met Arg Arg Leu His Leu
    5410                5415                5420                
Ile Val Thr Arg Gln Pro Asn Arg Ala Phe Glu Asp Val Lys Val Phe
5425                5430                5435                5440
Trp Arg Val Thr Leu Asn Lys Thr Val Val Val Leu Gln Lys Asp Gly
                5445                5450                5455    
Val Asn Leu Val Glu Glu Leu Gln Ser Val Ser Gly Thr Thr Thr Cys
            5460                5465                5470        
Thr Met Gly Gln Thr Lys Cys Phe Ile Ser Ile Glu Leu Lys Pro Glu
        5475                5480                5485            
Lys Val Pro Gln Val Glu Val Tyr Phe Phe Val Glu Leu Tyr Glu Ala
    5490                5495                5500                
Thr Ala Gly Ala Ala Ile Asn Asn Ser Ala Arg Phe Ala Gln Ile Lys
5505                5510                5515                5520
Ile Leu Glu Ser Asp Glu Ser Gln Ser Leu Val Tyr Phe Ser Val Gly
                5525                5530                5535    
Ser Arg Leu Ala Val Ala His Lys Lys Ala Thr Leu Ile Ser Leu Gln
            5540                5545                5550        
Val Ala Arg Asp Ser Gly Thr Gly Leu Met Met Ser Val Asn Phe Ser
        5555                5560                5565            
Thr Gln Glu Leu Arg Ser Ala Glu Thr Ile Gly Arg Thr Ile Ile Ser
    5570                5575                5580                
Pro Ala Ile Ser Gly Lys Asp Phe Val Ile Thr Glu Gly Thr Leu Val
5585                5590                5595                5600
Phe Glu Pro Gly Gln Arg Ser Thr Val Leu Asp Val Ile Leu Thr Pro
                5605                5610                5615    
Glu Thr Gly Ser Leu Asn Ser Phe Pro Lys Arg Phe Gln Ile Val Leu
            5620                5625                5630        
Phe Asp Pro Lys Gly Gly Ala Arg Ile Asp Lys Val Tyr Gly Thr Ala
        5635                5640                5645            
Asn Ile Thr Leu Val Ser Asp Ala Asp Ser Gln Ala Ile Trp Gly Leu
    5650                5655                5660                
Ala Asp Gln Leu His Gln Pro Val Asn Asp Asp Ile Leu Asn Arg Val
5665                5670                5675                5680
Leu His Thr Ile Ser Met Lys Val Ala Thr Glu Asn Thr Asp Glu Gln
                5685                5690                5695    
Leu Ser Ala Met Met His Leu Ile Glu Lys Ile Thr Thr Glu Gly Lys
            5700                5705                5710        
Ile Gln Ala Phe Ser Val Ala Ser Arg Thr Leu Phe Tyr Glu Ile Leu
        5715                5720                5725            
Cys Ser Leu Ile Asn Pro Lys Arg Lys Asp Thr Arg Gly Phe Ser His
    5730                5735                5740                
Phe Ala Glu Val Thr Glu Asn Phe Ala Phe Ser Leu Leu Thr Asn Val
5745                5750                5755                5760
Thr Cys Gly Ser Pro Gly Glu Lys Ser Lys Thr Ile Leu Asp Ser Cys
                5765                5770                5775    
Pro Tyr Leu Ser Ile Leu Ala Leu His Trp Tyr Pro Gln Gln Ile Asn
            5780                5785                5790        
Gly His Lys Phe Glu Gly Lys Glu Gly Asp Tyr Ile Arg Ile Pro Glu
        5795                5800                5805            
Arg Leu Leu Asp Val Gln Asp Ala Glu Ile Met Ala Gly Lys Ser Thr
    5810                5815                5820                
Cys Lys Leu Val Gln Phe Thr Glu Tyr Ser Ser Gln Gln Trp Phe Ile
5825                5830                5835                5840
Ser Gly Asn Asn Leu Pro Thr Leu Lys Asn Lys Val Leu Ser Leu Ser
                5845                5850                5855    
Val Lys Gly Gln Ser Ser Gln Leu Leu Thr Asn Asp Asn Glu Val Leu
            5860                5865                5870        
Tyr Arg Ile Tyr Ala Ala Glu Pro Arg Ile Ile Pro Gln Thr Ser Leu
        5875                5880                5885            
Cys Leu Leu Trp Asn Gln Ala Ala Ala Ser Trp Leu Ser Asp Ser Gln
    5890                5895                5900                
Phe Cys Lys Val Val Glu Glu Thr Ala Asp Tyr Val Glu Cys Ala Cys
5905                5910                5915                5920
Ser His Met Ser Val Tyr Ala Val Tyr Ala Arg Thr Asp Asn Leu Ser
                5925                5930                5935    
Ser Tyr Asn Glu Ala Phe Phe Thr Ser Gly Phe Ile Cys Ile Ser Gly
            5940                5945                5950        
Leu Cys Leu Ala Val Leu Ser His Ile Phe Cys Ala Arg Tyr Ser Met
        5955                5960                5965            
Phe Ala Ala Lys Leu Leu Thr His Met Met Ala Ala Ser Leu Gly Thr
    5970                5975                5980                
Gln Ile Leu Phe Leu Ala Ser Ala Tyr Ala Ser Pro Gln Leu Ala Glu
5985                5990                5995                6000
Glu Ser Cys Ser Ala Met Ala Ala Val Thr His Tyr Leu Tyr Leu Cys
                6005                6010                6015    
Gln Phe Ser Trp Met Leu Ile Gln Ser Val Asn Phe Trp Tyr Val Leu
            6020                6025                6030        
Val Met Asn Asp Glu His Thr Glu Arg Arg Tyr Leu Leu Phe Phe Leu
        6035                6040                6045            
Leu Ser Trp Gly Leu Pro Ala Phe Val Val Ile Leu Leu Ile Val Ile
    6050                6055                6060                
Leu Lys Gly Ile Tyr His Gln Ser Met Ser Gln Ile Tyr Gly Leu Ile
6065                6070                6075                6080
His Gly Asp Leu Cys Phe Ile Pro Asn Val Tyr Ala Ala Leu Phe Thr
                6085                6090                6095    
Ala Ala Leu Val Pro Leu Thr Cys Leu Val Val Val Phe Val Val Phe
            6100                6105                6110        
Ile His Ala Tyr Gln Val Lys Pro Gln Trp Lys Ala Tyr Asp Asp Val
        6115                6120                6125            
Phe Arg Gly Arg Thr Asn Ala Ala Glu Ile Pro Leu Ile Leu Tyr Leu
    6130                6135                6140                
Phe Ala Leu Ile Ser Val Thr Trp Leu Trp Gly Gly Leu His Met Ala
6145                6150                6155                6160
Tyr Arg His Phe Trp Met Leu Val Leu Phe Val Ile Phe Asn Ser Leu
                6165                6170                6175    
Gln Gly Leu Tyr Val Phe Met Val Tyr Phe Ile Leu His Asn Gln Met
            6180                6185                6190        
Cys Cys Pro Met Lys Ala Ser Tyr Thr Val Glu Met Asn Gly His Pro
        6195                6200                6205            
Gly Pro Ser Thr Ala Phe Phe Thr Pro Gly Ser Gly Met Pro Pro Ala
    6210                6215                6220                
Gly Gly Glu Ile Ser Lys Ser Thr Gln Asn Leu Ile Gly Ala Met Glu
6225                6230                6235                6240
Glu Val Pro Pro Asp Trp Glu Arg Ala Ser Phe Gln Gln Gly Ser Gln
                6245                6250                6255    
Ala Ser Pro Asp Leu Lys Pro Ser Pro Gln Asn Gly Ala Thr Phe Pro
            6260                6265                6270        
Ser Ser Gly Gly Tyr Gly Gln Gly Ser Leu Ile Ala Asp Glu Glu Ser
        6275                6280                6285            
Gln Glu Phe Asp Asp Leu Ile Phe Ala Leu Lys Thr Gly Ala Gly Leu
    6290                6295                6300                
Ser Val Ser Asp Asn Glu Ser Gly Gln Gly Ser Gln Glu Gly Gly Thr
6305                6310                6315                6320
Leu Thr Asp Ser Gln Ile Val Glu Leu Arg Arg Ile Pro Ile Ala Asp
                6325                6330                6335    
Thr His Leu
            


<210> 5763
<211> 1865
<212> PRT
<213> Homo sapiens

<400> 5763
Met Ile Glu Asp Lys Gly Pro Arg Val Ala Asp Tyr Phe Val Val Ala
 1               5                  10                  15      
Gly Leu Thr Asp Val Ser Lys Pro Leu Glu Glu Glu Ile His Phe Asn
            20                  25                  30          
Asp Ala Cys His Lys Val Ala Lys Pro Lys Glu Pro Ile Thr Asp Val
        35                  40                  45              
Ser Val Ile Ile Lys Ser Leu Gly Glu Glu Val Pro Gln Asp Tyr Ile
    50                  55                  60                  
Cys Ile Asp Val Thr Pro Thr Gly Leu Ser Ala Asp Leu Asn Asn Gly
65                  70                  75                  80  
Ser Leu Val Gly Pro Gln Ile Tyr Leu Cys Tyr Arg Arg Gly Arg Asp
                85                  90                  95      
Lys Pro Pro Leu Thr Asp Leu Gly Val Leu Tyr Asp Trp Lys Glu Arg
            100                 105                 110         
Leu Lys Gln Gly Cys Glu Ile Ile Gln Ser Thr Pro Tyr Gly Arg Pro
        115                 120                 125             
Ala Asn Ile Ser Gly Ser Thr Ser Ser Gln Arg Ile Tyr Ile Thr Tyr
    130                 135                 140                 
Arg Arg Ala Ser Glu Asn Met Thr Gln Asn Thr Leu Ala Val Thr Asp
145                 150                 155                 160 
Ile Cys Ile Ile Ile Pro Ser Lys Gly Glu Ser Pro Pro His Thr Phe
                165                 170                 175     
Cys Lys Val Asp Lys Asn Leu Asn Asn Ser Met Trp Gly Ser Ala Val
            180                 185                 190         
Tyr Leu Cys Tyr Lys Lys Ser Val Ala Lys Thr Asn Thr Val Ser Tyr
        195                 200                 205             
Lys Ala Gly Leu Ile Cys Arg Tyr Pro Gln Glu Asp Tyr Glu Ser Phe
    210                 215                 220                 
Ser Leu Pro Glu Ser Val Pro Leu Phe Cys Leu Pro Met Gly Ala Thr
225                 230                 235                 240 
Ile Glu Cys Trp Pro Ser Asn Ser Lys Tyr Pro Leu Pro Val Phe Ser
                245                 250                 255     
Thr Phe Val Leu Thr Gly Ala Ser Ala Glu Lys Val Tyr Gly Ala Ala
            260                 265                 270         
Ile Gln Phe Tyr Glu Pro Tyr Ser Glu Glu Asn Leu Thr Glu Lys Gln
        275                 280                 285             
Arg Leu Leu Leu Gly Leu Thr Ser Ala Asp Gly Lys Ser Asp Ser Ser
    290                 295                 300                 
Lys Thr Ile His Thr Asn Lys Cys Ile Cys Leu Leu Ser His Trp Pro
305                 310                 315                 320 
Phe Phe Asp Ala Phe Arg Lys Phe Leu Thr Phe Leu Tyr Arg Tyr Ser
                325                 330                 335     
Ile Ser Gly Pro His Val Leu Pro Ile Glu Lys His Ile Ser His Phe
            340                 345                 350         
Met His Lys Val Pro Phe Pro Ser Pro Gln Arg Pro Arg Ile Leu Val
        355                 360                 365             
Gln Leu Ser Pro His Asp Asn Leu Ile Leu Ser Gln Pro Val Ser Ser
    370                 375                 380                 
Pro Leu Pro Leu Ser Gly Gly Lys Phe Ser Thr Leu Leu Gln Asn Leu
385                 390                 395                 400 
Gly Pro Glu Asn Ala Val Thr Leu Leu Val Phe Ala Val Thr Glu His
                405                 410                 415     
Lys Ile Leu Ile His Ser Leu Arg Pro Ser Val Leu Thr Ser Val Thr
            420                 425                 430         
Glu Ala Leu Val Ser Met Ile Phe Pro Phe His Trp Pro Cys Pro Tyr
        435                 440                 445             
Val Pro Leu Cys Pro Leu Ala Leu Ala Asp Val Leu Ser Ala Pro Cys
    450                 455                 460                 
Pro Phe Ile Val Gly Ile Asp Ser Arg Tyr Phe Asp Leu Tyr Asp Pro
465                 470                 475                 480 
Pro Pro Asp Val Ser Cys Val Asp Val Asp Thr Asn Thr Ile Ser Gln
                485                 490                 495     
Ile Gly Asp Lys Lys Asn Val Ala Trp Lys Ile Leu Pro Lys Lys Pro
            500                 505                 510         
Cys Lys Asn Leu Met Asn Thr Leu Asn Asn Leu His Gln Gln Leu Ala
        515                 520                 525             
Lys Leu Gln Gln Arg Pro Arg Asp Asp Gly Leu Met Asp Leu Ala Ile
    530                 535                 540                 
Asn Asp Tyr Asp Phe Asn Ser Gly Lys Arg Leu His Met Ile Asp Leu
545                 550                 555                 560 
Glu Ile Gln Glu Ala Phe Leu Phe Phe Met Ala Ser Ile Leu Lys Gly
                565                 570                 575     
Tyr Arg Ser Tyr Leu Arg Pro Ile Thr Gln Ala Pro Ser Glu Thr Ala
            580                 585                 590         
Thr Asp Ala Ala Ser Leu Phe Ala Leu Gln Ala Phe Leu Arg Ser Arg
        595                 600                 605             
Asp Arg Ser His Gln Lys Phe Tyr Asn Met Met Thr Lys Thr Gln Met
    610                 615                 620                 
Phe Ile Arg Phe Ile Glu Glu Cys Ser Phe Val Ser Asp Lys Asp Ala
625                 630                 635                 640 
Ser Leu Ala Phe Phe Asp Asp Cys Val Asp Lys Val Asp Met Asp Lys
                645                 650                 655     
Ser Gly Glu Val Arg Leu Ile Glu Leu Asp Glu Ser Phe Lys Ser Glu
            660                 665                 670         
His Thr Val Phe Val Thr Pro Pro Glu Ile Pro His Leu Pro Asn Gly
        675                 680                 685             
Glu Glu Pro Pro Leu Gln Tyr Ser Tyr Asn Gly Phe Pro Val Leu Arg
    690                 695                 700                 
Asn Asn Leu Phe Glu Arg Pro Glu Gly Phe Leu Gln Ala Lys Lys Asn
705                 710                 715                 720 
Lys Leu Pro Ser Lys Ser Ser Ser Pro Asn Ser Pro Leu Pro Met Phe
                725                 730                 735     
Arg Arg Thr Lys Gln Glu Ile Lys Ser Ala His Lys Ile Ala Lys Arg
            740                 745                 750         
Tyr Ser Ser Ile Pro Gln Met Trp Ser Arg Cys Leu Leu Arg His Cys
        755                 760                 765             
Tyr Gly Leu Trp Phe Ile Cys Leu Pro Ala Tyr Val Lys Val Cys His
    770                 775                 780                 
Ser Lys Val Arg Ala Leu Lys Thr Ala Tyr Asp Val Leu Lys Lys Met
785                 790                 795                 800 
Gln Ser Lys Lys Met Asp Pro Pro Asp Glu Val Cys Tyr Arg Ile Leu
                805                 810                 815     
Met Gln Leu Cys Gly Gln Tyr Asp Gln Pro Val Leu Ala Val Arg Val
            820                 825                 830         
Leu Phe Glu Met Gln Lys Ala Gly Ile Asp Pro Asn Ala Ile Thr Tyr
        835                 840                 845             
Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Thr Trp Pro Ser Arg Ser
    850                 855                 860                 
Arg Ser Gly Tyr Phe Leu Trp Thr Lys Val Arg Asn Val Val Leu Gly
865                 870                 875                 880 
Val Thr Gln Phe Lys Arg Ala Leu Lys Lys His Ala His Leu Ser Gln
                885                 890                 895     
Thr Thr Leu Ser Gly Gly Gln Ser Asp Leu Gly Tyr Asn Ser Leu Ser
            900                 905                 910         
Lys Asp Glu Val Arg Arg Gly Asp Thr Ser Thr Glu Asp Ile Gln Glu
        915                 920                 925             
Glu Lys Asp Lys Lys Gly Ser Asp Cys Ser Ser Leu Ser Glu Ser Glu
    930                 935                 940                 
Ser Thr Lys Gly Ser Ala Asp Cys Leu Pro Lys Leu Ser Tyr Gln Asn
945                 950                 955                 960 
Ser Ser Ser Ile Val Arg Leu Thr Gly Thr Ser Asn Asn Ser Ala Gly
                965                 970                 975     
Lys Ile Ser Gly Glu Ser Met Gly Lys Glu Ser Thr Pro Glu Leu Leu
            980                 985                 990         
Leu Ile Ser Ser Leu Glu Asp Thr Asn Glu Thr Arg Asn Ile Gln Ser
        995                 1000                1005            
Arg Cys Phe Arg Lys Arg His Lys Ser Asp Asn Glu Thr Asn Leu Gln
    1010                1015                1020                
Gln Gln Val Val Trp Gly Asn Arg Asn Arg Asn Leu Ser Gly Gly Val
1025                1030                1035                1040
Leu Met Gly Phe Met Leu Asn Arg Ile Asn Gln Glu Ala Thr Pro Gly
                1045                1050                1055    
Asp Ile Val Glu Lys Leu Gly Ala Asp Ala Lys Ile Leu Ser Asn Val
            1060                1065                1070        
Ile Ser Lys Ser Thr Arg Pro Asn Thr Leu Asp Ile Gly Lys Pro Pro
        1075                1080                1085            
Leu Arg Ser Lys Arg Asp Ser Leu Glu Lys Glu Ser Ser Asp Asp Asp
    1090                1095                1100                
Thr Pro Phe Asp Gly Ser Asn Tyr Leu Ala Asp Lys Val Asp Ser Pro
1105                1110                1115                1120
Val Ile Phe Asp Leu Glu Asp Leu Asp Ser Glu Thr Asp Val Ser Lys
                1125                1130                1135    
Ala Gly Cys Val Ala Thr Gln Asn Pro Lys Arg Ile Gln Arg Met Asn
            1140                1145                1150        
Ser Ser Phe Ser Val Lys Pro Phe Glu Lys Thr Asp Val Ala Thr Gly
        1155                1160                1165            
Phe Asp Pro Leu Ser Leu Leu Val Ala Glu Thr Glu Gln Gln Gln Lys
    1170                1175                1180                
Glu Glu Glu Glu Glu Asp Glu Asp Asp Ser Lys Ser Ile Ser Thr Pro
1185                1190                1195                1200
Ser Ala Arg Arg Asp Leu Ala Glu Glu Ile Val Met Tyr Met Asn Asn
                1205                1210                1215    
Met Ser Ser Pro Leu Thr Ser Arg Thr Pro Ser Ile Asp Leu Gln Arg
            1220                1225                1230        
Ala Cys Asp Asp Lys Leu Asn Lys Lys Ser Pro Pro Leu Val Lys Ala
        1235                1240                1245            
Cys Arg Arg Ser Ser Leu Pro Pro Asn Ser Pro Lys Pro Val Arg Leu
    1250                1255                1260                
Thr Lys Ser Lys Ser Tyr Thr Lys Ser Glu Glu Lys Pro Arg Asp Arg
1265                1270                1275                1280
Leu Trp Ser Ser Pro Ala Phe Ser Pro Thr Cys Pro Phe Arg Glu Glu
                1285                1290                1295    
Ser Gln Asp Thr Leu Thr His Ser Ser Pro Ser Phe Asn Leu Asp Thr
            1300                1305                1310        
Leu Leu Val Pro Lys Leu Asp Val Leu Arg Asn Ser Met Phe Thr Ala
        1315                1320                1325            
Gly Lys Gly Val Ala Glu Lys Ala Ser Lys Trp Tyr Ser Arg Phe Thr
    1330                1335                1340                
Met Tyr Thr Thr Ser Ser Lys Asp Gln Ser Ser Asp Arg Thr Ser Leu
1345                1350                1355                1360
Ser Ser Val Gly Ala Gln Asp Ser Glu Ser Thr Ser Leu Thr Asp Glu
                1365                1370                1375    
Asp Val Cys His Glu Leu Glu Gly Pro Ile Ser Ser Gln Glu Thr Ser
            1380                1385                1390        
Ala Thr Ser Gly Thr Lys Arg Ile Asp Leu Ser Arg Ile Ser Leu Glu
        1395                1400                1405            
Ser Ser Ala Ser Leu Glu Gly Ser Leu Ser Lys Phe Ala Leu Pro Gly
    1410                1415                1420                
Lys Ser Glu Val Thr Ser Ser Phe Asn Ala Ser Asn Thr Asn Ile Phe
1425                1430                1435                1440
Gln Asn Tyr Ala Met Glu Val Leu Ile Ser Ser Cys Ser Arg Cys Arg
                1445                1450                1455    
Thr Cys Asp Cys Leu Val His Asp Glu Glu Ile Met Ala Gly Trp Thr
            1460                1465                1470        
Ala Asp Asp Ser Asn Leu Asn Thr Thr Cys Pro Phe Cys Gly Asn Ile
        1475                1480                1485            
Phe Leu Pro Phe Leu Asn Ile Glu Ile Arg Asp Leu Arg Arg Pro Gly
    1490                1495                1500                
Arg Tyr Phe Leu Lys Ser Ser Pro Ser Thr Glu Asn Met His Phe Pro
1505                1510                1515                1520
Ser Ser Ile Ser Ser Gln Thr Arg Gln Ser Cys Ile Ser Thr Ser Ala
                1525                1530                1535    
Ser Gly Leu Asp Thr Ser Ala Leu Ser Val Gln Gly Asn Phe Asp Leu
            1540                1545                1550        
Asn Ser Lys Ser Lys Leu Gln Glu Asn Phe Cys Thr Arg Ser Ile Gln
        1555                1560                1565            
Ile Pro Ala Asn Arg Ser Lys Thr Ala Met Ser Lys Cys Pro Ile Phe
    1570                1575                1580                
Pro Met Ala Arg Ser Ile Ser Thr Ser Gly Pro Leu Asp Lys Glu Asp
1585                1590                1595                1600
Thr Gly Arg Gln Lys Leu Ile Ser Thr Gly Ser Leu Pro Ala Thr Leu
                1605                1610                1615    
Gln Gly Ala Thr Asp Ser Leu Gly Leu Glu Trp His Leu Pro Ser Pro
            1620                1625                1630        
Asp Pro Val Thr Val Pro Tyr Leu Ser Pro Leu Val Val Trp Lys Glu
        1635                1640                1645            
Leu Glu Ser Leu Leu Glu Asn Glu Gly Asp His Ala Ile Thr Val Ala
    1650                1655                1660                
Asp Phe Val Asp His His Pro Ile Val Phe Trp Asn Leu Val Trp Tyr
1665                1670                1675                1680
Phe Arg Arg Leu Asp Leu Pro Ser Asn Leu Pro Gly Leu Ile Leu Ser
                1685                1690                1695    
Ser Glu His Cys Asn Lys Tyr Ser Lys Ile Pro Arg His Cys Met Ser
            1700                1705                1710        
Glu Asp Ser Lys Tyr Val Leu Ile Gln Met Leu Trp Asp Asn Met Lys
        1715                1720                1725            
Leu His Gln Asp Pro Gly Gln Pro Leu Tyr Ile Leu Trp Asn Ala His
    1730                1735                1740                
Thr Gln Lys Tyr Pro Met Val His Leu Leu Gln Lys Ser Asp Asn Ser
1745                1750                1755                1760
Phe Asn Gln Glu Leu Leu Lys Ser Met Val Lys Ser Ile Lys Met Asn
                1765                1770                1775    
Asp Val Tyr Gly Pro Met Ser Gln Ile Leu Glu Thr Leu Asn Lys Cys
            1780                1785                1790        
Pro His Phe Lys Arg Gln Arg Ser Leu Tyr Arg Glu Ile Leu Phe Leu
        1795                1800                1805            
Ser Leu Val Ala Leu Gly Arg Glu Asn Ile Asp Ile Asp Ala Phe Asp
    1810                1815                1820                
Lys Glu Tyr Lys Met Ala Tyr Asp Arg Leu Thr Pro Ser Gln Val Lys
1825                1830                1835                1840
Ser Thr His Asn Cys Asp Arg Pro Pro Ser Thr Gly Val Met Glu Cys
                1845                1850                1855    
Arg Lys Thr Phe Gly Glu Pro Tyr Leu
            1860                1865


<210> 5764
<211> 1906
<212> PRT
<213> Homo sapiens

<400> 5764
Met Ile Glu Asp Lys Gly Pro Arg Val Ala Asp Tyr Phe Val Val Ala
 1               5                  10                  15      
Gly Leu Thr Asp Val Ser Lys Pro Leu Glu Glu Glu Ile His Phe Asn
            20                  25                  30          
Asp Ala Cys His Lys Val Ala Lys Pro Lys Glu Pro Ile Thr Asp Val
        35                  40                  45              
Ser Val Ile Ile Lys Ser Leu Gly Glu Glu Val Pro Gln Asp Tyr Ile
    50                  55                  60                  
Cys Ile Asp Val Thr Pro Thr Gly Leu Ser Ala Asp Leu Asn Asn Gly
65                  70                  75                  80  
Ser Leu Val Gly Pro Gln Ile Tyr Leu Cys Tyr Arg Arg Gly Arg Asp
                85                  90                  95      
Lys Pro Pro Leu Thr Asp Leu Gly Val Leu Tyr Asp Trp Lys Glu Arg
            100                 105                 110         
Leu Lys Gln Gly Cys Glu Ile Ile Gln Ser Thr Pro Tyr Gly Arg Pro
        115                 120                 125             
Ala Asn Ile Ser Gly Ser Thr Ser Ser Gln Arg Ile Tyr Ile Thr Tyr
    130                 135                 140                 
Arg Arg Ala Ser Glu Asn Met Thr Gln Asn Thr Leu Ala Val Thr Asp
145                 150                 155                 160 
Ile Cys Ile Ile Ile Pro Ser Lys Gly Glu Ser Pro Pro His Thr Phe
                165                 170                 175     
Cys Lys Val Asp Lys Asn Leu Asn Asn Ser Met Trp Gly Ser Ala Val
            180                 185                 190         
Tyr Leu Cys Tyr Lys Lys Ser Val Ala Lys Thr Asn Thr Val Ser Tyr
        195                 200                 205             
Lys Ala Gly Leu Ile Cys Arg Tyr Pro Gln Glu Asp Tyr Glu Ser Phe
    210                 215                 220                 
Ser Leu Pro Glu Ser Val Pro Leu Phe Cys Leu Pro Met Gly Ala Thr
225                 230                 235                 240 
Ile Glu Cys Trp Pro Ser Asn Ser Lys Tyr Pro Leu Pro Val Phe Ser
                245                 250                 255     
Thr Phe Val Leu Thr Gly Ala Ser Ala Glu Lys Val Tyr Gly Ala Ala
            260                 265                 270         
Ile Gln Phe Tyr Glu Pro Tyr Ser Glu Glu Asn Leu Thr Glu Lys Gln
        275                 280                 285             
Arg Leu Leu Leu Gly Leu Thr Ser Ala Asp Gly Lys Ser Asp Ser Ser
    290                 295                 300                 
Lys Thr Ile His Thr Asn Lys Cys Ile Cys Leu Leu Ser His Trp Pro
305                 310                 315                 320 
Phe Phe Asp Ala Phe Arg Lys Phe Leu Thr Phe Leu Tyr Arg Tyr Ser
                325                 330                 335     
Ile Ser Gly Pro His Val Leu Pro Ile Glu Lys His Ile Ser His Phe
            340                 345                 350         
Met His Lys Val Pro Phe Pro Ser Pro Gln Arg Pro Arg Ile Leu Val
        355                 360                 365             
Gln Leu Ser Pro His Asp Asn Leu Ile Leu Ser Gln Pro Val Ser Ser
    370                 375                 380                 
Pro Leu Pro Leu Ser Gly Gly Lys Phe Ser Thr Leu Leu Gln Asn Leu
385                 390                 395                 400 
Gly Pro Glu Asn Ala Val Thr Leu Leu Val Phe Ala Val Thr Glu His
                405                 410                 415     
Lys Ile Leu Ile His Ser Leu Arg Pro Ser Val Leu Thr Ser Val Thr
            420                 425                 430         
Glu Ala Leu Val Ser Met Ile Phe Pro Phe His Trp Pro Cys Pro Tyr
        435                 440                 445             
Val Pro Leu Cys Pro Leu Ala Leu Ala Asp Val Leu Ser Ala Pro Cys
    450                 455                 460                 
Pro Phe Ile Val Gly Ile Asp Ser Arg Tyr Phe Asp Leu Tyr Asp Pro
465                 470                 475                 480 
Pro Pro Asp Val Ser Cys Val Asp Val Asp Thr Asn Thr Ile Ser Gln
                485                 490                 495     
Ile Gly Asp Lys Lys Asn Val Ala Trp Lys Ile Leu Pro Lys Lys Pro
            500                 505                 510         
Cys Lys Asn Leu Met Asn Thr Leu Asn Asn Leu His Gln Gln Leu Ala
        515                 520                 525             
Lys Leu Gln Gln Arg Pro Arg Asp Asp Gly Leu Met Asp Leu Ala Ile
    530                 535                 540                 
Asn Asp Tyr Asp Phe Asn Ser Gly Lys Arg Leu His Met Ile Asp Leu
545                 550                 555                 560 
Glu Ile Gln Glu Ala Phe Leu Phe Phe Met Ala Ser Ile Leu Lys Gly
                565                 570                 575     
Tyr Arg Ser Tyr Leu Arg Pro Ile Thr Gln Ala Pro Ser Glu Thr Ala
            580                 585                 590         
Thr Asp Ala Ala Ser Leu Phe Ala Leu Gln Ala Phe Leu Arg Ser Arg
        595                 600                 605             
Asp Arg Ser His Gln Lys Phe Tyr Asn Met Met Thr Lys Thr Gln Met
    610                 615                 620                 
Phe Ile Arg Phe Ile Glu Glu Cys Ser Phe Val Ser Asp Lys Asp Ala
625                 630                 635                 640 
Ser Leu Ala Phe Phe Asp Asp Cys Val Asp Lys Val Asp Met Asp Lys
                645                 650                 655     
Ser Gly Glu Val Arg Leu Ile Glu Leu Asp Glu Ser Phe Lys Ser Glu
            660                 665                 670         
His Thr Val Phe Val Thr Pro Pro Glu Ile Pro His Leu Pro Asn Gly
        675                 680                 685             
Glu Glu Pro Pro Leu Gln Tyr Ser Tyr Asn Gly Phe Pro Val Leu Arg
    690                 695                 700                 
Asn Asn Leu Phe Glu Arg Pro Glu Gly Phe Leu Gln Ala Lys Lys Asn
705                 710                 715                 720 
Lys Leu Pro Ser Lys Ser Ser Ser Pro Asn Ser Pro Leu Pro Met Phe
                725                 730                 735     
Arg Arg Thr Lys Gln Glu Ile Lys Ser Ala His Lys Ile Ala Lys Arg
            740                 745                 750         
Tyr Ser Ser Ile Pro Gln Met Trp Ser Arg Cys Leu Leu Arg His Cys
        755                 760                 765             
Tyr Gly Leu Trp Phe Ile Cys Leu Pro Ala Tyr Val Lys Val Cys His
    770                 775                 780                 
Ser Lys Val Arg Ala Leu Lys Thr Ala Tyr Asp Val Leu Lys Lys Met
785                 790                 795                 800 
Gln Ser Lys Lys Met Asp Pro Pro Asp Glu Val Cys Tyr Arg Ile Leu
                805                 810                 815     
Met Gln Leu Cys Gly Gln Tyr Asp Gln Pro Val Leu Ala Val Arg Val
            820                 825                 830         
Leu Phe Glu Met Gln Lys Ala Gly Ile Asp Pro Asn Ala Ile Thr Tyr
        835                 840                 845             
Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Thr Trp Pro Ser Arg Ser
    850                 855                 860                 
Arg Ser Gly Tyr Phe Leu Trp Thr Lys Val Arg Asn Val Val Leu Gly
865                 870                 875                 880 
Val Thr Gln Phe Lys Arg Ala Leu Lys Lys His Ala His Leu Ser Gln
                885                 890                 895     
Thr Thr Leu Ser Asp Gly Ser Asp Leu Asp Ala Val Ser His Gly Ser
            900                 905                 910         
Met Asp Ser Gly His Gly Thr His Thr Val Glu Gln Ala Pro Phe Asn
        915                 920                 925             
Thr Gly Leu Ile Lys Val Tyr Ala Thr Asp Asp Arg Ser Ser Thr Gly
    930                 935                 940                 
Gly Gln Ser Asp Leu Gly Tyr Asn Ser Leu Ser Lys Asp Glu Val Arg
945                 950                 955                 960 
Arg Gly Asp Thr Ser Thr Glu Asp Ile Gln Glu Glu Lys Asp Lys Lys
                965                 970                 975     
Gly Ser Asp Cys Ser Ser Leu Ser Glu Ser Glu Ser Thr Lys Gly Ser
            980                 985                 990         
Ala Asp Cys Leu Pro Lys Leu Ser Tyr Gln Asn Ser Ser Ser Ile Val
        995                 1000                1005            
Arg Leu Thr Gly Thr Ser Asn Asn Ser Ala Gly Lys Ile Ser Gly Glu
    1010                1015                1020                
Ser Met Glu Ser Thr Pro Glu Leu Leu Leu Ile Ser Ser Leu Glu Asp
1025                1030                1035                1040
Thr Asn Glu Thr Arg Asn Ile Gln Ser Arg Cys Phe Arg Lys Arg His
                1045                1050                1055    
Lys Ser Asp Asn Glu Thr Asn Leu Gln Gln Gln Val Val Trp Gly Asn
            1060                1065                1070        
Arg Asn Arg Asn Leu Ser Gly Gly Val Leu Met Gly Phe Met Leu Asn
        1075                1080                1085            
Arg Ile Asn Gln Glu Ala Thr Pro Gly Asp Ile Val Glu Lys Leu Gly
    1090                1095                1100                
Ala Asp Ala Lys Ile Leu Ser Asn Val Ile Ser Lys Ser Thr Arg Pro
1105                1110                1115                1120
Asn Thr Leu Asp Ile Gly Lys Pro Pro Leu Arg Ser Lys Arg Asp Ser
                1125                1130                1135    
Leu Glu Lys Glu Ser Ser Asp Asp Asp Thr Pro Phe Asp Gly Ser Asn
            1140                1145                1150        
Tyr Leu Ala Asp Lys Val Asp Ser Pro Val Ile Phe Asp Leu Glu Asp
        1155                1160                1165            
Leu Asp Ser Glu Thr Asp Val Ser Lys Ala Gly Cys Val Ala Thr Gln
    1170                1175                1180                
Asn Pro Lys Arg Ile Gln Arg Met Asn Ser Ser Phe Ser Val Lys Pro
1185                1190                1195                1200
Phe Glu Lys Thr Asp Val Ala Thr Gly Phe Asp Pro Leu Ser Leu Leu
                1205                1210                1215    
Val Ala Glu Thr Glu Gln Gln Gln Lys Glu Glu Glu Glu Glu Asp Glu
            1220                1225                1230        
Asp Asp Ser Lys Ser Ile Ser Thr Pro Ser Ala Arg Arg Asp Leu Ala
        1235                1240                1245            
Glu Glu Ile Val Met Tyr Met Asn Asn Met Ser Ser Pro Leu Thr Ser
    1250                1255                1260                
Arg Thr Pro Ser Ile Asp Leu Gln Arg Ala Cys Asp Asp Lys Leu Asn
1265                1270                1275                1280
Lys Lys Ser Pro Pro Leu Val Lys Ala Cys Arg Arg Ser Ser Leu Pro
                1285                1290                1295    
Pro Asn Ser Pro Lys Pro Val Arg Leu Thr Lys Ser Lys Ser Tyr Thr
            1300                1305                1310        
Lys Ser Glu Glu Lys Pro Arg Asp Arg Leu Trp Ser Ser Pro Ala Phe
        1315                1320                1325            
Ser Pro Thr Cys Pro Phe Arg Glu Glu Ser Gln Asp Thr Leu Thr His
    1330                1335                1340                
Ser Ser Pro Ser Phe Asn Leu Asp Thr Leu Leu Val Pro Lys Leu Asp
1345                1350                1355                1360
Val Leu Arg Asn Ser Met Phe Thr Ala Gly Lys Gly Val Ala Glu Lys
                1365                1370                1375    
Ala Ser Lys Trp Tyr Ser Arg Phe Thr Met Tyr Thr Thr Ser Ser Lys
            1380                1385                1390        
Asp Gln Ser Ser Asp Arg Thr Ser Leu Ser Ser Val Gly Ala Gln Asp
        1395                1400                1405            
Ser Glu Ser Thr Ser Leu Thr Asp Glu Asp Val Cys His Glu Leu Glu
    1410                1415                1420                
Gly Pro Ile Ser Ser Gln Glu Thr Ser Ala Thr Ser Gly Thr Lys Arg
1425                1430                1435                1440
Ile Asp Leu Ser Arg Ile Ser Leu Glu Ser Ser Ala Ser Leu Glu Gly
                1445                1450                1455    
Ser Leu Ser Lys Phe Ala Leu Pro Gly Lys Ser Glu Val Thr Ser Ser
            1460                1465                1470        
Phe Asn Ala Ser Asn Thr Asn Ile Phe Gln Asn Tyr Ala Met Glu Val
        1475                1480                1485            
Leu Ile Ser Ser Cys Ser Arg Cys Arg Thr Cys Asp Cys Leu Val His
    1490                1495                1500                
Asp Glu Glu Ile Met Ala Gly Trp Thr Ala Asp Asp Ser Asn Leu Asn
1505                1510                1515                1520
Thr Thr Cys Pro Phe Cys Gly Asn Ile Phe Leu Pro Phe Leu Asn Ile
                1525                1530                1535    
Glu Ile Arg Asp Leu Arg Arg Pro Gly Arg Tyr Phe Leu Lys Ser Ser
            1540                1545                1550        
Pro Ser Thr Glu Asn Met His Phe Pro Ser Ser Ile Ser Ser Gln Thr
        1555                1560                1565            
Arg Gln Ser Cys Ile Ser Thr Ser Ala Ser Gly Leu Asp Thr Ser Ala
    1570                1575                1580                
Leu Ser Val Gln Gly Asn Phe Asp Leu Asn Ser Lys Ser Lys Leu Gln
1585                1590                1595                1600
Glu Asn Phe Cys Thr Arg Ser Ile Gln Ile Pro Ala Asn Arg Ser Lys
                1605                1610                1615    
Thr Ala Met Ser Lys Cys Pro Ile Phe Pro Met Ala Arg Ser Ile Ser
            1620                1625                1630        
Thr Ser Gly Pro Leu Asp Lys Glu Asp Thr Gly Arg Gln Lys Leu Ile
        1635                1640                1645            
Ser Thr Gly Ser Leu Pro Ala Thr Leu Gln Gly Ala Thr Asp Ser Leu
    1650                1655                1660                
Gly Leu Glu Trp His Leu Pro Ser Pro Asp Pro Val Thr Val Pro Tyr
1665                1670                1675                1680
Leu Ser Pro Leu Val Val Trp Lys Glu Leu Glu Ser Leu Leu Glu Asn
                1685                1690                1695    
Glu Gly Asp His Ala Ile Thr Val Ala Asp Phe Val Asp His His Pro
            1700                1705                1710        
Ile Val Phe Trp Asn Leu Val Trp Tyr Phe Arg Arg Leu Asp Leu Pro
        1715                1720                1725            
Ser Asn Leu Pro Gly Leu Ile Leu Ser Ser Glu His Cys Asn Lys Tyr
    1730                1735                1740                
Ser Lys Ile Pro Arg His Cys Met Ser Glu Asp Ser Lys Tyr Val Leu
1745                1750                1755                1760
Ile Gln Met Leu Trp Asp Asn Met Lys Leu His Gln Asp Pro Gly Gln
                1765                1770                1775    
Pro Leu Tyr Ile Leu Trp Asn Ala His Thr Gln Lys Tyr Pro Met Val
            1780                1785                1790        
His Leu Leu Gln Lys Ser Asp Asn Ser Phe Asn Gln Glu Leu Leu Lys
        1795                1800                1805            
Ser Met Val Lys Ser Ile Lys Met Asn Asp Val Tyr Gly Pro Met Ser
    1810                1815                1820                
Gln Ile Leu Glu Thr Leu Asn Lys Cys Pro His Phe Lys Arg Gln Arg
1825                1830                1835                1840
Ser Leu Tyr Arg Glu Ile Leu Phe Leu Ser Leu Val Ala Leu Gly Arg
                1845                1850                1855    
Glu Asn Ile Asp Ile Asp Ala Phe Asp Lys Glu Tyr Lys Met Ala Tyr
            1860                1865                1870        
Asp Arg Leu Thr Pro Ser Gln Val Lys Ser Thr His Asn Cys Asp Arg
        1875                1880                1885            
Pro Pro Ser Thr Gly Val Met Glu Cys Arg Lys Thr Phe Gly Glu Pro
    1890                1895                1900                
Tyr Leu
1905    


<210> 5765
<211> 226
<212> PRT
<213> Homo sapiens

<400> 5765
Met Ser Phe Ala Glu Ser Gly Trp Arg Ser Ala Leu Arg Arg Arg Gly
 1               5                  10                  15      
Pro Gly Thr Pro Gly Pro Val Ala Arg Pro Ser Tyr Ser Ser Phe Thr
            20                  25                  30          
Gln Gly Asp Ser Trp Gly Glu Gly Glu Val Asp Glu Glu Glu Gly Cys
        35                  40                  45              
Asp Gln Val Ala Arg Asp Leu Arg Ala Glu Phe Ser Ala Gly Ala Trp
    50                  55                  60                  
Ser Glu Pro Arg Lys Arg Ser Val Leu Pro Pro Asp Gly Asn Gly Ser
65                  70                  75                  80  
Pro Val Leu Pro Asp Lys Arg Asn Gly Ile Phe Pro Ala Ala Ala Gly
                85                  90                  95      
Ser Arg Ala Gln Pro Arg Arg Trp Pro Val Gln Val Leu Ser Ile Leu
            100                 105                 110         
Cys Ser Leu Leu Phe Ala Ile Leu Leu Ala Phe Leu Leu Ala Ile Ala
        115                 120                 125             
Tyr Leu Ile Val Lys Glu Leu His Ala Glu Asn Leu Lys Asn Glu Asp
    130                 135                 140                 
Asp Val Asp Thr Gly Leu Leu Gly Phe Trp Thr Leu Leu Ile Ile Ser
145                 150                 155                 160 
Leu Thr Ala Gly Phe Ser Cys Cys Ser Phe Ser Trp Thr Val Thr Tyr
                165                 170                 175     
Phe Asp Ser Phe Glu Pro Gly Met Phe Pro Pro Thr Pro Leu Ser Pro
            180                 185                 190         
Ala Arg Phe Lys Lys Leu Thr Gly His Ser Phe His Met Gly Tyr Ser
        195                 200                 205             
Met Ala Ile Leu Asn Gly Ile Val Ala Ala Leu Thr Val Ala Trp Cys
    210                 215                 220                 
Leu Met
225     


<210> 5766
<211> 1888
<212> PRT
<213> Homo sapiens

<400> 5766
Met Val Pro Leu Val Pro Ala Leu Val Met Leu Gly Leu Val Ala Gly
 1               5                  10                  15      
Ala His Gly Asp Ser Lys Pro Val Phe Ile Lys Val Pro Glu Asp Gln
            20                  25                  30          
Thr Gly Leu Ser Gly Gly Val Ala Ser Phe Val Cys Gln Ala Thr Gly
        35                  40                  45              
Glu Pro Lys Pro Arg Ile Thr Trp Met Lys Lys Gly Lys Lys Val Ser
    50                  55                  60                  
Ser Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ala Gly Ser Val
65                  70                  75                  80  
Leu Arg Ile Gln Pro Leu Arg Val Gln Arg Asp Glu Ala Ile Tyr Glu
                85                  90                  95      
Cys Thr Ala Thr Asn Ser Leu Gly Glu Ile Asn Thr Ser Ala Lys Leu
            100                 105                 110         
Ser Val Leu Glu Glu Glu Gln Leu Pro Pro Gly Phe Pro Ser Ile Asp
        115                 120                 125             
Met Gly Pro Gln Leu Lys Val Val Glu Lys Ala Arg Thr Ala Thr Met
    130                 135                 140                 
Leu Cys Ala Ala Gly Gly Asn Pro Asp Pro Glu Ile Ser Trp Phe Lys
145                 150                 155                 160 
Asp Phe Leu Pro Val Asp Pro Ala Thr Ser Asn Gly Arg Ile Lys Gln
                165                 170                 175     
Leu Arg Ser Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu Ser Asp Gln
            180                 185                 190         
Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser
        195                 200                 205             
Ala Pro Ala Asn Leu Tyr Val Arg Val Arg Arg Val Ala Pro Arg Phe
    210                 215                 220                 
Ser Ile Pro Pro Ser Ser Gln Glu Val Met Pro Gly Gly Ser Val Asn
225                 230                 235                 240 
Leu Thr Cys Val Ala Val Gly Ala Pro Met Pro Tyr Val Lys Trp Met
                245                 250                 255     
Met Gly Ala Glu Glu Leu Thr Lys Glu Asp Glu Met Pro Val Gly Arg
            260                 265                 270         
Asn Val Leu Glu Leu Ser Asn Val Val Arg Ser Ala Asn Tyr Thr Cys
        275                 280                 285             
Val Ala Ile Ser Ser Leu Gly Met Ile Glu Ala Thr Ala Gln Val Thr
    290                 295                 300                 
Val Lys Ala Leu Pro Lys Pro Pro Ile Asp Leu Val Val Thr Glu Thr
305                 310                 315                 320 
Thr Ala Thr Ser Val Thr Leu Thr Trp Asp Ser Gly Asn Ser Glu Pro
                325                 330                 335     
Val Thr Tyr Tyr Gly Ile Gln Tyr Arg Ala Ala Gly Thr Glu Gly Pro
            340                 345                 350         
Phe Gln Glu Val Asp Gly Val Ala Thr Thr Arg Tyr Ser Ile Gly Gly
        355                 360                 365             
Leu Ser Pro Phe Ser Glu Tyr Ala Phe Arg Val Leu Ala Val Asn Ser
    370                 375                 380                 
Ile Gly Arg Gly Pro Pro Ser Glu Ala Val Arg Ala Arg Thr Gly Glu
385                 390                 395                 400 
Gln Ala Pro Ser Ser Pro Pro Arg Arg Val Gln Ala Arg Met Leu Ser
                405                 410                 415     
Ala Ser Thr Met Leu Val Gln Trp Glu Pro Pro Glu Glu Pro Asn Gly
            420                 425                 430         
Leu Val Arg Gly Tyr Arg Val Tyr Tyr Thr Pro Asp Ser Arg Arg Pro
        435                 440                 445             
Pro Asn Ala Trp His Lys His Asn Thr Asp Ala Gly Leu Leu Thr Thr
    450                 455                 460                 
Val Gly Ser Leu Leu Pro Gly Ile Thr Tyr Ser Leu Arg Val Leu Ala
465                 470                 475                 480 
Phe Thr Ala Val Gly Asp Gly Pro Pro Ser Pro Thr Ile Gln Val Lys
                485                 490                 495     
Thr Gln Gln Gly Val Pro Ala Gln Pro Ala Asp Phe Gln Ala Glu Val
            500                 505                 510         
Glu Ser Asp Thr Arg Ile Gln Leu Ser Trp Leu Leu Pro Pro Gln Glu
        515                 520                 525             
Arg Ile Ile Met Tyr Glu Leu Val Tyr Trp Ala Ala Glu Asp Glu Asp
    530                 535                 540                 
Gln Gln His Lys Val Thr Phe Asp Pro Thr Ser Ser Tyr Thr Leu Glu
545                 550                 555                 560 
Asp Leu Lys Pro Asp Thr Leu Tyr Arg Phe Gln Leu Ala Ala Arg Ser
                565                 570                 575     
Asp Met Gly Val Gly Val Phe Thr Pro Thr Ile Glu Ala Arg Thr Ala
            580                 585                 590         
Gln Ser Thr Pro Ser Ala Pro Pro Gln Lys Val Met Cys Val Ser Met
        595                 600                 605             
Gly Ser Thr Thr Val Arg Val Ser Trp Val Pro Pro Pro Ala Asp Ser
    610                 615                 620                 
Arg Asn Gly Val Ile Thr Gln Tyr Ser Val Ala His Glu Ala Val Asp
625                 630                 635                 640 
Gly Glu Asp Arg Gly Arg His Val Val Asp Gly Ile Ser Arg Glu His
                645                 650                 655     
Ser Ser Trp Asp Leu Val Gly Leu Glu Lys Trp Thr Glu Tyr Arg Val
            660                 665                 670         
Trp Val Arg Ala His Thr Asp Val Gly Pro Gly Pro Glu Ser Ser Pro
        675                 680                 685             
Val Leu Val Arg Thr Asp Glu Asp Val Pro Ser Gly Pro Pro Arg Lys
    690                 695                 700                 
Val Glu Val Glu Pro Leu Asn Ser Thr Ala Val His Val Tyr Trp Lys
705                 710                 715                 720 
Leu Pro Val Pro Ser Lys Gln His Gly Gln Ile Arg Gly Tyr Gln Val
                725                 730                 735     
Thr Tyr Val Arg Leu Glu Asn Gly Glu Pro Arg Gly Leu Pro Ile Ile
            740                 745                 750         
Gln Asp Val Met Leu Ala Glu Ala Gln Glu Thr Thr Ile Ser Gly Leu
        755                 760                 765             
Thr Pro Glu Thr Thr Tyr Ser Val Thr Val Ala Ala Tyr Thr Thr Lys
    770                 775                 780                 
Gly Asp Gly Ala Arg Ser Lys Pro Lys Ile Val Thr Thr Thr Gly Ala
785                 790                 795                 800 
Val Pro Gly Arg Pro Thr Met Met Ile Ser Thr Thr Ala Met Asn Thr
                805                 810                 815     
Ala Leu Leu Gln Trp His Pro Pro Lys Glu Leu Pro Gly Glu Leu Leu
            820                 825                 830         
Gly Tyr Arg Leu Gln Tyr Cys Arg Ala Asp Glu Ala Arg Pro Asn Thr
        835                 840                 845             
Ile Asp Phe Gly Lys Asp Asp Gln His Phe Thr Val Thr Gly Leu His
    850                 855                 860                 
Lys Gly Thr Thr Tyr Ile Phe Arg Leu Ala Ala Lys Asn Arg Ala Gly
865                 870                 875                 880 
Leu Gly Glu Glu Phe Glu Lys Glu Ile Arg Thr Pro Glu Asp Leu Pro
                885                 890                 895     
Ser Gly Phe Pro Gln Asn Leu His Val Thr Gly Leu Thr Thr Ser Thr
            900                 905                 910         
Thr Glu Leu Ala Trp Asp Pro Pro Val Leu Ala Glu Arg Asn Gly Arg
        915                 920                 925             
Ile Ile Ser Tyr Thr Val Val Phe Arg Asp Ile Asn Ser Gln Gln Glu
    930                 935                 940                 
Leu Gln Asn Ile Thr Thr Asp Thr Arg Phe Thr Leu Thr Gly Leu Lys
945                 950                 955                 960 
Pro Asp Thr Thr Tyr Asp Ile Lys Val Arg Ala Trp Thr Ser Lys Gly
                965                 970                 975     
Ser Gly Pro Leu Ser Pro Ser Ile Gln Ser Arg Thr Met Pro Val Glu
            980                 985                 990         
Gln Val Phe Ala Lys Asn Phe Arg Val Ala Ala Ala Met Lys Thr Ser
        995                 1000                1005            
Val Leu Leu Ser Trp Glu Val Pro Asp Ser Tyr Lys Ser Ala Val Pro
    1010                1015                1020                
Phe Lys Ile Leu Tyr Asn Gly Gln Ser Val Glu Val Asp Gly His Ser
1025                1030                1035                1040
Met Arg Lys Leu Ile Ala Asp Leu Gln Pro Asn Thr Glu Tyr Ser Phe
                1045                1050                1055    
Val Leu Met Asn Arg Gly Ser Ser Ala Gly Gly Leu Gln His Leu Val
            1060                1065                1070        
Ser Ile Arg Thr Ala Pro Asp Leu Leu Pro His Lys Pro Leu Pro Ala
        1075                1080                1085            
Ser Ala Tyr Ile Glu Asp Gly Arg Phe Asp Leu Ser Met Pro His Val
    1090                1095                1100                
Gln Asp Pro Ser Leu Val Arg Trp Phe Tyr Ile Val Val Val Pro Ile
1105                1110                1115                1120
Asp Arg Val Gly Gly Ser Met Leu Thr Pro Arg Trp Ser Thr Pro Glu
                1125                1130                1135    
Glu Leu Glu Leu Asp Glu Leu Leu Glu Ala Ile Glu Gln Gly Gly Glu
            1140                1145                1150        
Glu Gln Arg Arg Arg Arg Arg Gln Ala Glu Arg Leu Lys Pro Tyr Val
        1155                1160                1165            
Ala Ala Gln Leu Asp Val Leu Pro Glu Thr Phe Thr Leu Gly Asp Lys
    1170                1175                1180                
Lys Asn Tyr Arg Gly Phe Tyr Asn Arg Pro Leu Ser Pro Asp Leu Ser
1185                1190                1195                1200
Tyr Gln Cys Phe Val Leu Ala Ser Leu Lys Glu Pro Met Asp Gln Lys
                1205                1210                1215    
Arg Tyr Ala Ser Ser Pro Tyr Ser Asp Glu Ile Val Val Gln Val Thr
            1220                1225                1230        
Pro Ala Gln Gln Gln Glu Glu Pro Glu Met Leu Trp Val Thr Gly Pro
        1235                1240                1245            
Val Leu Ala Val Ile Leu Ile Ile Leu Ile Val Ile Ala Ile Leu Leu
    1250                1255                1260                
Phe Lys Arg Lys Arg Thr His Ser Pro Ser Ser Lys Asp Glu Gln Ser
1265                1270                1275                1280
Ile Gly Leu Lys Asp Ser Leu Leu Ala His Ser Ser Asp Pro Val Glu
                1285                1290                1295    
Met Arg Arg Leu Asn Tyr Gln Thr Pro Gly Met Arg Asp His Pro Pro
            1300                1305                1310        
Ile Pro Ile Thr Asp Leu Ala Asp Asn Ile Glu Arg Leu Lys Ala Asn
        1315                1320                1325            
Asp Gly Leu Lys Phe Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln
    1330                1335                1340                
Gln Phe Thr Trp Glu Asn Ser Asn Leu Glu Val Asn Lys Pro Lys Asn
1345                1350                1355                1360
Arg Tyr Ala Asn Val Ile Ala Tyr Asp His Ser Arg Val Ile Leu Thr
                1365                1370                1375    
Ser Ile Asp Gly Val Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile
            1380                1385                1390        
Asp Gly Tyr Arg Lys Gln Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu
        1395                1400                1405            
Pro Glu Thr Met Gly Asp Phe Trp Arg Met Val Trp Glu Gln Arg Thr
    1410                1415                1420                
Ala Thr Val Val Met Met Thr Arg Leu Glu Glu Lys Ser Arg Val Lys
1425                1430                1435                1440
Cys Asp Gln Tyr Trp Pro Ala Arg Gly Thr Glu Thr Cys Gly Leu Ile
                1445                1450                1455    
Gln Val Thr Leu Leu Asp Thr Val Glu Leu Ala Thr Tyr Thr Val Arg
            1460                1465                1470        
Thr Phe Ala Leu His Lys Ser Gly Ser Ser Glu Lys Arg Glu Leu Arg
        1475                1480                1485            
Gln Phe Gln Phe Met Ala Trp Pro Asp His Gly Val Pro Glu Tyr Pro
    1490                1495                1500                
Thr Pro Ile Leu Ala Phe Leu Arg Arg Val Lys Ala Cys Asn Pro Leu
1505                1510                1515                1520
Asp Ala Gly Pro Met Val Val His Cys Ser Ala Gly Val Gly Arg Thr
                1525                1530                1535    
Gly Cys Phe Ile Val Ile Asp Ala Met Leu Glu Arg Met Lys His Glu
            1540                1545                1550        
Lys Thr Val Asp Ile Tyr Gly His Val Thr Cys Met Arg Ser Gln Arg
        1555                1560                1565            
Asn Tyr Met Val Gln Thr Glu Asp Gln Tyr Val Phe Ile His Glu Ala
    1570                1575                1580                
Leu Leu Glu Ala Ala Thr Cys Gly His Thr Glu Val Pro Ala Arg Asn
1585                1590                1595                1600
Leu Tyr Ala His Ile Gln Lys Leu Gly Gln Val Pro Pro Gly Glu Ser
                1605                1610                1615    
Val Thr Ala Met Glu Leu Glu Phe Lys Leu Leu Ala Ser Ser Lys Ala
            1620                1625                1630        
His Thr Ser Arg Phe Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys
        1635                1640                1645            
Asn Arg Leu Val Asn Ile Met Pro Tyr Glu Leu Thr Arg Val Cys Leu
    1650                1655                1660                
Gln Pro Ile Arg Gly Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe
1665                1670                1675                1680
Leu Asp Gly Tyr Arg Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro
                1685                1690                1695    
Leu Ala Glu Ser Thr Glu Asp Phe Trp Arg Met Leu Trp Glu His Asn
            1700                1705                1710        
Ser Thr Ile Ile Val Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu
        1715                1720                1725            
Lys Cys His Gln Tyr Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr
    1730                1735                1740                
Phe Val Val Asp Pro Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu
1745                1750                1755                1760
Arg Glu Phe Lys Val Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Ile
                1765                1770                1775    
Arg Gln Phe Gln Phe Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Thr
            1780                1785                1790        
Gly Glu Gly Phe Ile Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu
        1795                1800                1805            
Gln Phe Gly Gln Asp Gly Pro Ile Thr Val His Cys Ser Ala Gly Val
    1810                1815                1820                
Gly Arg Thr Gly Val Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met
1825                1830                1835                1840
Arg Tyr Glu Gly Val Val Asp Met Phe Gln Thr Val Lys Thr Leu Arg
                1845                1850                1855    
Thr Gln Arg Pro Ala Met Val Gln Thr Glu Asp Gln Tyr Gln Leu Cys
            1860                1865                1870        
Tyr Arg Ala Ala Leu Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr
        1875                1880                1885            


<210> 5767
<211> 1897
<212> PRT
<213> Homo sapiens

<400> 5767
Met Val Pro Leu Val Pro Ala Leu Val Met Leu Gly Leu Val Ala Gly
 1               5                  10                  15      
Ala His Gly Asp Ser Lys Pro Val Phe Ile Lys Val Pro Glu Asp Gln
            20                  25                  30          
Thr Gly Leu Ser Gly Gly Val Ala Ser Phe Val Cys Gln Ala Thr Gly
        35                  40                  45              
Glu Pro Lys Pro Arg Ile Thr Trp Met Lys Lys Gly Lys Lys Val Ser
    50                  55                  60                  
Ser Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ala Gly Ser Val
65                  70                  75                  80  
Leu Arg Ile Gln Pro Leu Arg Val Gln Arg Asp Glu Ala Ile Tyr Glu
                85                  90                  95      
Cys Thr Ala Thr Asn Ser Leu Gly Glu Ile Asn Thr Ser Ala Lys Leu
            100                 105                 110         
Ser Val Leu Glu Glu Glu Gln Leu Pro Pro Gly Phe Pro Ser Ile Asp
        115                 120                 125             
Met Gly Pro Gln Leu Lys Val Val Glu Lys Ala Arg Thr Ala Thr Met
    130                 135                 140                 
Leu Cys Ala Ala Gly Gly Asn Pro Asp Pro Glu Ile Ser Trp Phe Lys
145                 150                 155                 160 
Asp Phe Leu Pro Val Asp Pro Ala Thr Ser Asn Gly Arg Ile Lys Gln
                165                 170                 175     
Leu Arg Ser Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu Ser Asp Gln
            180                 185                 190         
Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser
        195                 200                 205             
Ala Pro Ala Asn Leu Tyr Val Arg Val Arg Arg Val Ala Pro Arg Phe
    210                 215                 220                 
Ser Ile Pro Pro Ser Ser Gln Glu Val Met Pro Gly Gly Ser Val Asn
225                 230                 235                 240 
Leu Thr Cys Val Ala Val Gly Ala Pro Met Pro Tyr Val Lys Trp Met
                245                 250                 255     
Met Gly Ala Glu Glu Leu Thr Lys Glu Asp Glu Met Pro Val Gly Arg
            260                 265                 270         
Asn Val Leu Glu Leu Ser Asn Val Val Arg Ser Ala Asn Tyr Thr Cys
        275                 280                 285             
Val Ala Ile Ser Ser Leu Gly Met Ile Glu Ala Thr Ala Gln Val Thr
    290                 295                 300                 
Val Lys Ala Leu Pro Lys Pro Pro Ile Asp Leu Val Val Thr Glu Thr
305                 310                 315                 320 
Thr Ala Thr Ser Val Thr Leu Thr Trp Asp Ser Gly Asn Ser Glu Pro
                325                 330                 335     
Val Thr Tyr Tyr Gly Ile Gln Tyr Arg Ala Ala Gly Thr Glu Gly Pro
            340                 345                 350         
Phe Gln Glu Val Asp Gly Val Ala Thr Thr Arg Tyr Ser Ile Gly Gly
        355                 360                 365             
Leu Ser Pro Phe Ser Glu Tyr Ala Phe Arg Val Leu Ala Val Asn Ser
    370                 375                 380                 
Ile Gly Arg Gly Pro Pro Ser Glu Ala Val Arg Ala Arg Thr Gly Glu
385                 390                 395                 400 
Gln Ala Pro Ser Ser Pro Pro Arg Arg Val Gln Ala Arg Met Leu Ser
                405                 410                 415     
Ala Ser Thr Met Leu Val Gln Trp Glu Pro Pro Glu Glu Pro Asn Gly
            420                 425                 430         
Leu Val Arg Gly Tyr Arg Val Tyr Tyr Thr Pro Asp Ser Arg Arg Pro
        435                 440                 445             
Pro Asn Ala Trp His Lys His Asn Thr Asp Ala Gly Leu Leu Thr Thr
    450                 455                 460                 
Val Gly Ser Leu Leu Pro Gly Ile Thr Tyr Ser Leu Arg Val Leu Ala
465                 470                 475                 480 
Phe Thr Ala Val Gly Asp Gly Pro Pro Ser Pro Thr Ile Gln Val Lys
                485                 490                 495     
Thr Gln Gln Gly Val Pro Ala Gln Pro Ala Asp Phe Gln Ala Glu Val
            500                 505                 510         
Glu Ser Asp Thr Arg Ile Gln Leu Ser Trp Leu Leu Pro Pro Gln Glu
        515                 520                 525             
Arg Ile Ile Met Tyr Glu Leu Val Tyr Trp Ala Ala Glu Asp Glu Asp
    530                 535                 540                 
Gln Gln His Lys Val Thr Phe Asp Pro Thr Ser Ser Tyr Thr Leu Glu
545                 550                 555                 560 
Asp Leu Lys Pro Asp Thr Leu Tyr Arg Phe Gln Leu Ala Ala Arg Ser
                565                 570                 575     
Asp Met Gly Val Gly Val Phe Thr Pro Thr Ile Glu Ala Arg Thr Ala
            580                 585                 590         
Gln Ser Thr Pro Ser Ala Pro Pro Gln Lys Val Met Cys Val Ser Met
        595                 600                 605             
Gly Ser Thr Thr Val Arg Val Ser Trp Val Pro Pro Pro Ala Asp Ser
    610                 615                 620                 
Arg Asn Gly Val Ile Thr Gln Tyr Ser Val Ala His Glu Ala Val Asp
625                 630                 635                 640 
Gly Glu Asp Arg Gly Arg His Val Val Asp Gly Ile Ser Arg Glu His
                645                 650                 655     
Ser Ser Trp Asp Leu Val Gly Leu Glu Lys Trp Thr Glu Tyr Arg Val
            660                 665                 670         
Trp Val Arg Ala His Thr Asp Val Gly Pro Gly Pro Glu Ser Ser Pro
        675                 680                 685             
Val Leu Val Arg Thr Asp Glu Asp Val Pro Ser Gly Pro Pro Arg Lys
    690                 695                 700                 
Val Glu Val Glu Pro Leu Asn Ser Thr Ala Val His Val Tyr Trp Lys
705                 710                 715                 720 
Leu Pro Val Pro Ser Lys Gln His Gly Gln Ile Arg Gly Tyr Gln Val
                725                 730                 735     
Thr Tyr Val Arg Leu Glu Asn Gly Glu Pro Arg Gly Leu Pro Ile Ile
            740                 745                 750         
Gln Asp Val Met Leu Ala Glu Ala Gln Trp Arg Pro Glu Glu Ser Glu
        755                 760                 765             
Asp Tyr Glu Thr Thr Ile Ser Gly Leu Thr Pro Glu Thr Thr Tyr Ser
    770                 775                 780                 
Val Thr Val Ala Ala Tyr Thr Thr Lys Gly Asp Gly Ala Arg Ser Lys
785                 790                 795                 800 
Pro Lys Ile Val Thr Thr Thr Gly Ala Val Pro Gly Arg Pro Thr Met
                805                 810                 815     
Met Ile Ser Thr Thr Ala Met Asn Thr Ala Leu Leu Gln Trp His Pro
            820                 825                 830         
Pro Lys Glu Leu Pro Gly Glu Leu Leu Gly Tyr Arg Leu Gln Tyr Cys
        835                 840                 845             
Arg Ala Asp Glu Ala Arg Pro Asn Thr Ile Asp Phe Gly Lys Asp Asp
    850                 855                 860                 
Gln His Phe Thr Val Thr Gly Leu His Lys Gly Thr Thr Tyr Ile Phe
865                 870                 875                 880 
Arg Leu Ala Ala Lys Asn Arg Ala Gly Leu Gly Glu Glu Phe Glu Lys
                885                 890                 895     
Glu Ile Arg Thr Pro Glu Asp Leu Pro Ser Gly Phe Pro Gln Asn Leu
            900                 905                 910         
His Val Thr Gly Leu Thr Thr Ser Thr Thr Glu Leu Ala Trp Asp Pro
        915                 920                 925             
Pro Val Leu Ala Glu Arg Asn Gly Arg Ile Ile Ser Tyr Thr Val Val
    930                 935                 940                 
Phe Arg Asp Ile Asn Ser Gln Gln Glu Leu Gln Asn Ile Thr Thr Asp
945                 950                 955                 960 
Thr Arg Phe Thr Leu Thr Gly Leu Lys Pro Asp Thr Thr Tyr Asp Ile
                965                 970                 975     
Lys Val Arg Ala Trp Thr Ser Lys Gly Ser Gly Pro Leu Ser Pro Ser
            980                 985                 990         
Ile Gln Ser Arg Thr Met Pro Val Glu Gln Val Phe Ala Lys Asn Phe
        995                 1000                1005            
Arg Val Ala Ala Ala Met Lys Thr Ser Val Leu Leu Ser Trp Glu Val
    1010                1015                1020                
Pro Asp Ser Tyr Lys Ser Ala Val Pro Phe Lys Ile Leu Tyr Asn Gly
1025                1030                1035                1040
Gln Ser Val Glu Val Asp Gly His Ser Met Arg Lys Leu Ile Ala Asp
                1045                1050                1055    
Leu Gln Pro Asn Thr Glu Tyr Ser Phe Val Leu Met Asn Arg Gly Ser
            1060                1065                1070        
Ser Ala Gly Gly Leu Gln His Leu Val Ser Ile Arg Thr Ala Pro Asp
        1075                1080                1085            
Leu Leu Pro His Lys Pro Leu Pro Ala Ser Ala Tyr Ile Glu Asp Gly
    1090                1095                1100                
Arg Phe Asp Leu Ser Met Pro His Val Gln Asp Pro Ser Leu Val Arg
1105                1110                1115                1120
Trp Phe Tyr Ile Val Val Val Pro Ile Asp Arg Val Gly Gly Ser Met
                1125                1130                1135    
Leu Thr Pro Arg Trp Ser Thr Pro Glu Glu Leu Glu Leu Asp Glu Leu
            1140                1145                1150        
Leu Glu Ala Ile Glu Gln Gly Gly Glu Glu Gln Arg Arg Arg Arg Arg
        1155                1160                1165            
Gln Ala Glu Arg Leu Lys Pro Tyr Val Ala Ala Gln Leu Asp Val Leu
    1170                1175                1180                
Pro Glu Thr Phe Thr Leu Gly Asp Lys Lys Asn Tyr Arg Gly Phe Tyr
1185                1190                1195                1200
Asn Arg Pro Leu Ser Pro Asp Leu Ser Tyr Gln Cys Phe Val Leu Ala
                1205                1210                1215    
Ser Leu Lys Glu Pro Met Asp Gln Lys Arg Tyr Ala Ser Ser Pro Tyr
            1220                1225                1230        
Ser Asp Glu Ile Val Val Gln Val Thr Pro Ala Gln Gln Gln Glu Glu
        1235                1240                1245            
Pro Glu Met Leu Trp Val Thr Gly Pro Val Leu Ala Val Ile Leu Ile
    1250                1255                1260                
Ile Leu Ile Val Ile Ala Ile Leu Leu Phe Lys Arg Lys Arg Thr His
1265                1270                1275                1280
Ser Pro Ser Ser Lys Asp Glu Gln Ser Ile Gly Leu Lys Asp Ser Leu
                1285                1290                1295    
Leu Ala His Ser Ser Asp Pro Val Glu Met Arg Arg Leu Asn Tyr Gln
            1300                1305                1310        
Thr Pro Gly Met Arg Asp His Pro Pro Ile Pro Ile Thr Asp Leu Ala
        1315                1320                1325            
Asp Asn Ile Glu Arg Leu Lys Ala Asn Asp Gly Leu Lys Phe Ser Gln
    1330                1335                1340                
Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu Asn Ser
1345                1350                1355                1360
Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala
                1365                1370                1375    
Tyr Asp His Ser Arg Val Ile Leu Thr Ser Ile Asp Gly Val Pro Gly
            1380                1385                1390        
Ser Asp Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr Arg Lys Gln Asn
        1395                1400                1405            
Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Met Gly Asp Phe
    1410                1415                1420                
Trp Arg Met Val Trp Glu Gln Arg Thr Ala Thr Val Val Met Met Thr
1425                1430                1435                1440
Arg Leu Glu Glu Lys Ser Arg Val Lys Cys Asp Gln Tyr Trp Pro Ala
                1445                1450                1455    
Arg Gly Thr Glu Thr Cys Gly Leu Ile Gln Val Thr Leu Leu Asp Thr
            1460                1465                1470        
Val Glu Leu Ala Thr Tyr Thr Val Arg Thr Phe Ala Leu His Lys Ser
        1475                1480                1485            
Gly Ser Ser Glu Lys Arg Glu Leu Arg Gln Phe Gln Phe Met Ala Trp
    1490                1495                1500                
Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Ile Leu Ala Phe Leu
1505                1510                1515                1520
Arg Arg Val Lys Ala Cys Asn Pro Leu Asp Ala Gly Pro Met Val Val
                1525                1530                1535    
His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile Asp
            1540                1545                1550        
Ala Met Leu Glu Arg Met Lys His Glu Lys Thr Val Asp Ile Tyr Gly
        1555                1560                1565            
His Val Thr Cys Met Arg Ser Gln Arg Asn Tyr Met Val Gln Thr Glu
    1570                1575                1580                
Asp Gln Tyr Val Phe Ile His Glu Ala Leu Leu Glu Ala Ala Thr Cys
1585                1590                1595                1600
Gly His Thr Glu Val Pro Ala Arg Asn Leu Tyr Ala His Ile Gln Lys
                1605                1610                1615    
Leu Gly Gln Val Pro Pro Gly Glu Ser Val Thr Ala Met Glu Leu Glu
            1620                1625                1630        
Phe Lys Leu Leu Ala Ser Ser Lys Ala His Thr Ser Arg Phe Ile Ser
        1635                1640                1645            
Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile Met
    1650                1655                1660                
Pro Tyr Glu Leu Thr Arg Val Cys Leu Gln Pro Ile Arg Gly Val Glu
1665                1670                1675                1680
Gly Ser Asp Tyr Ile Asn Ala Ser Phe Leu Asp Gly Tyr Arg Gln Gln
                1685                1690                1695    
Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Ser Thr Glu Asp
            1700                1705                1710        
Phe Trp Arg Met Leu Trp Glu His Asn Ser Thr Ile Ile Val Met Leu
        1715                1720                1725            
Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp Pro
    1730                1735                1740                
Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met Ala
1745                1750                1755                1760
Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp
                1765                1770                1775    
Ala Arg Asp Gly Gln Ser Arg Thr Ile Arg Gln Phe Gln Phe Thr Asp
            1780                1785                1790        
Trp Pro Glu Gln Gly Val Pro Lys Thr Gly Glu Gly Phe Ile Asp Phe
        1795                1800                1805            
Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro
    1810                1815                1820                
Ile Thr Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile
1825                1830                1835                1840
Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp
                1845                1850                1855    
Met Phe Gln Thr Val Lys Thr Leu Arg Thr Gln Arg Pro Ala Met Val
            1860                1865                1870        
Gln Thr Glu Asp Gln Tyr Gln Leu Cys Tyr Arg Ala Ala Leu Glu Tyr
        1875                1880                1885            
Leu Gly Ser Phe Asp His Tyr Ala Thr
    1890                1895        


<210> 5768
<211> 348
<212> PRT
<213> Homo sapiens

<400> 5768
Met Leu His Ser Ser Phe Pro Thr Ser His Pro His Pro Tyr Pro Ile
 1               5                  10                  15      
Pro Ser Ser Arg Pro Leu Pro Pro Ala Pro Cys Ser Cys Pro Val Leu
            20                  25                  30          
Ala Leu Pro Pro His Leu Pro Ala Ala Ser His Arg Ala Arg Lys Ala
        35                  40                  45              
Gly Thr Gln Thr Leu Ala Ser Ala Gln Ala Pro Val Gln Thr Pro Ala
    50                  55                  60                  
Pro Thr Leu Pro Gly Pro Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg
65                  70                  75                  80  
Val Val Arg Leu His Pro Val Leu Leu Ala Ser Thr Val Asp Ser Tyr
                85                  90                  95      
Glu Arg Arg Asn Lys Gly Ala Ala Arg Val Ile Gly Thr Leu Leu Gly
            100                 105                 110         
Thr Val Asn Lys His Ser Val Glu Val Thr Asn Cys Phe Ser Val Ser
        115                 120                 125             
Tyr Asn Glu Ser Asp Glu Val Val Val Asp Met Glu Phe Ala Lys Asn
    130                 135                 140                 
Met Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly
145                 150                 155                 160 
Trp Tyr Ala Ala Gly His Asp Ile Thr Glu His Ser Val Leu Ile His
                165                 170                 175     
Glu Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp
            180                 185                 190         
Thr Ser Leu Gln Asn Gly His Met Ser Ile Lys Ala Tyr Val Ser Thr
        195                 200                 205             
Leu Met Gly Val Pro Gly Arg Thr Val Gly Val Phe Thr Pro Leu Thr
    210                 215                 220                 
Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Cys Ile Arg Val Asp Leu Ile
225                 230                 235                 240 
Met Lys Thr Cys Phe Ser Pro Asn Arg Val Val Gly Leu Ser Ser Asp
                245                 250                 255     
Leu Gln Gln Val Gly Gly Ala Ser Ala His Ile Gln Asp Ala Leu Ser
            260                 265                 270         
Ile Val Leu Gln Tyr Ala Glu Asp Ile Leu Ser Ala Lys Val Ser Ala
        275                 280                 285             
Asp Asn Thr Ile Arg Lys Val Gly His Phe Leu Met Ser Leu Val Asn
    290                 295                 300                 
Gln Val Pro Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu His Ser
305                 310                 315                 320 
Asn Ile Asn Asp Leu Leu Met Val Ala Tyr Leu Ala Asn Leu Thr Gln
                325                 330                 335     
Ser Gln Ile Ala Leu Asn Glu Lys Arg Val Asn Leu
            340                 345             


<210> 5769
<211> 2351
<212> PRT
<213> Homo sapiens

<400> 5769
Met Phe Phe Lys Met Lys Asn Glu Ile Asp Asn Asp Pro Glu Ser Glu
 1               5                  10                  15      
Lys Cys Ile Lys Asp Ser Thr Ile Met Arg Arg Glu Pro Gln Asn Ile
            20                  25                  30          
Leu Ser Pro Leu Met Leu Pro Asn Leu Glu Ile Pro Phe Ser Val Lys
        35                  40                  45              
Asp Ile Ile Ser Arg Ile Glu Arg Ala Gln Leu His Arg Ala Arg Glu
    50                  55                  60                  
Asp Ile Asp Met Gln Leu Ser Glu Ile Met Asn Asn Val His Arg Ile
65                  70                  75                  80  
Met Thr Arg Tyr Thr Leu Val Phe Asn Ser Ser Ser Glu Arg Asn Val
                85                  90                  95      
Ser Leu Thr Glu His Lys Lys Lys Gln Arg Thr Asn Phe Leu Glu Lys
            100                 105                 110         
Met Ala Thr Tyr Ala Lys Thr Ile Glu Ile Arg Glu Lys Thr Leu Ala
        115                 120                 125             
Asn Ile Leu Ala Trp Leu Glu Glu Trp Asn Asp Val Leu Ser Glu Met
    130                 135                 140                 
Thr Leu Met Asp Val Asp Glu His His His Trp Ile Ala Gln Met Glu
145                 150                 155                 160 
Leu Leu Pro Asp Thr Leu Lys Ala Ile Glu Asn Asn Val Lys Ile Leu
                165                 170                 175     
Ser Arg Phe Ser Thr Ser Phe Leu Asp Glu Lys Lys Lys Gln Lys Lys
            180                 185                 190         
Lys Ile Leu Ser Arg Gly Thr Leu Trp Lys Ser Trp Lys Glu Arg Val
        195                 200                 205             
Ile Lys Arg Pro Ser Thr Ala Arg Ala Leu Arg Pro Asp Gln Met Ile
    210                 215                 220                 
Ser Asp Gln Leu Ala Thr Asn Thr Lys Val Ser Glu Ile Gln Gly Met
225                 230                 235                 240 
Leu Gln Glu Leu Ile Gly Thr Thr Met Phe Ser Thr Leu Glu Asn Asn
                245                 250                 255     
Ala Ile Lys Tyr Ile Ser Ser Thr Ile Val Asn Leu Ser Thr Ala Leu
            260                 265                 270         
Ser Met Leu Asn Asp Glu Leu Lys Cys Val Asn Phe Gln Ser Ser Thr
        275                 280                 285             
Val Tyr Ala His Glu Thr Ser Glu Ala Glu Lys Glu Leu Ser Leu Lys
    290                 295                 300                 
Ile Ile Arg Asp Leu Ser Asn Glu Asn Glu Met Leu Gln Gln Lys Leu
305                 310                 315                 320 
Gln Asp Ala Glu Glu Lys Cys Glu Gln Leu Ile Arg Ser Lys Ile Val
                325                 330                 335     
Ile Glu Gln Leu Tyr Ala Lys Leu Ser Thr Ser Ser Thr Leu Lys Val
            340                 345                 350         
Leu Pro Gly Pro Ser Pro Gln Ser Ser Arg Ala Ile Ile Lys Val Gly
        355                 360                 365             
Asp Thr Glu Asp Asn Met Asp Asn Ile Leu Asp Lys Glu Leu Glu Asn
    370                 375                 380                 
Ile Val Asp Glu Val Gln Arg Lys Glu Thr Lys Asp Ser Gly Ile Lys
385                 390                 395                 400 
Trp Asp Ser Thr Ile Ser Tyr Thr Ala Gln Ala Glu Arg Thr Pro Asp
                405                 410                 415     
Leu Thr Glu Leu Arg Gln Gln Pro Val Ala Ser Glu Asp Ile Ser Glu
            420                 425                 430         
Asp Ser Thr Lys Asp Asn Val Ser Leu Lys Lys Gly Asp Phe Tyr Gln
        435                 440                 445             
Glu Asp Glu Thr Asp Glu Tyr Gln Ser Trp Lys Arg Ser His Lys Lys
    450                 455                 460                 
Ala Thr Tyr Val Tyr Glu Thr Ser Gly Pro Asn Leu Ser Asp Asn Lys
465                 470                 475                 480 
Ser Gly Gln Lys Val Ser Glu Ala Lys Pro Ser Gln Tyr Tyr Glu Leu
                485                 490                 495     
Gln Val Leu Lys Lys Lys Arg Lys Glu Met Lys Ser Phe Ser Glu Asp
            500                 505                 510         
Lys Ser Lys Ser Pro Thr Glu Ala Lys Arg Lys His Leu Ser Leu Thr
        515                 520                 525             
Glu Thr Lys Ser Gln Gly Gly Lys Ser Gly Thr Ser Met Met Met Leu
    530                 535                 540                 
Glu Gln Phe Arg Lys Val Lys Arg Glu Ser Pro Phe Asp Lys Arg Pro
545                 550                 555                 560 
Thr Ala Ala Glu Ile Lys Val Glu Pro Thr Thr Glu Ser Leu Asp Lys
                565                 570                 575     
Glu Gly Lys Gly Glu Ile Arg Ser Leu Val Glu Pro Leu Ser Met Ile
            580                 585                 590         
Gln Phe Asp Asp Thr Ala Glu Pro Gln Lys Gly Lys Ile Lys Gly Lys
        595                 600                 605             
Lys His His Ile Ser Ser Gly Thr Ile Thr Ser Lys Glu Glu Lys Thr
    610                 615                 620                 
Glu Glu Lys Glu Glu Leu Thr Lys Gln Val Lys Ser His Gln Leu Val
625                 630                 635                 640 
Lys Ser Leu Ser Arg Val Ala Lys Glu Thr Ser Glu Ser Thr Arg Val
                645                 650                 655     
Leu Glu Ser Pro Asp Gly Lys Ser Glu Gln Ser Asn Leu Glu Glu Phe
            660                 665                 670         
Gln Glu Ala Ile Met Ala Phe Leu Lys Gln Lys Ile Asp Asn Ile Gly
        675                 680                 685             
Lys Ala Phe Asp Lys Lys Thr Val Pro Lys Glu Glu Glu Leu Leu Lys
    690                 695                 700                 
Arg Ala Glu Ala Glu Lys Leu Gly Ile Ile Lys Ala Lys Met Glu Glu
705                 710                 715                 720 
Tyr Phe Gln Lys Val Ala Glu Thr Val Thr Lys Ile Leu Arg Lys Tyr
                725                 730                 735     
Lys Asp Thr Lys Lys Glu Glu Gln Val Gly Glu Lys Pro Ile Lys Gln
            740                 745                 750         
Lys Lys Val Val Ser Phe Met Pro Gly Leu His Phe Gln Lys Ser Pro
        755                 760                 765             
Ile Ser Ala Lys Ser Glu Ser Ser Thr Leu Leu Ser Tyr Glu Ser Thr
    770                 775                 780                 
Asp Pro Val Ile Asn Asn Leu Ile Gln Met Ile Leu Ala Glu Ile Glu
785                 790                 795                 800 
Ser Glu Arg Asp Ile Pro Thr Val Ser Thr Val Gln Lys Asp His Lys
                805                 810                 815     
Glu Lys Glu Lys Gln Arg Gln Glu Gln Tyr Leu Gln Glu Gly Gln Glu
            820                 825                 830         
Gln Met Ser Gly Met Ser Leu Lys Gln Gln Leu Leu Gly Glu Arg Asn
        835                 840                 845             
Leu Leu Lys Glu His Tyr Glu Lys Ile Ser Glu Asn Trp Glu Glu Lys
    850                 855                 860                 
Lys Ala Trp Leu Gln Met Lys Glu Gly Lys Gln Glu Gln Gln Ser Gln
865                 870                 875                 880 
Lys Gln Trp Gln Glu Glu Glu Met Trp Lys Glu Glu Gln Lys Gln Ala
                885                 890                 895     
Thr Pro Lys Gln Ala Glu Gln Glu Glu Lys Gln Lys Gln Arg Gly Gln
            900                 905                 910         
Glu Glu Glu Glu Leu Pro Lys Ser Ser Leu Gln Arg Leu Glu Glu Gly
        915                 920                 925             
Thr Gln Lys Met Lys Thr Gln Gly Leu Leu Leu Glu Lys Glu Asn Gly
    930                 935                 940                 
Gln Met Arg Gln Ile Gln Lys Glu Ala Lys His Leu Gly Pro His Arg
945                 950                 955                 960 
Arg Arg Glu Lys Gly Lys Glu Lys Gln Lys Pro Glu Arg Gly Leu Glu
                965                 970                 975     
Asp Leu Glu Arg Gln Ile Lys Thr Lys Asp Gln Met Gln Met Lys Glu
            980                 985                 990         
Thr Gln Pro Lys Glu Leu Glu Lys Met Val Ile Gln Thr Pro Met Thr
        995                 1000                1005            
Leu Ser Pro Arg Trp Lys Ser Val Leu Lys Asp Val Gln Arg Ser Tyr
    1010                1015                1020                
Glu Gly Lys Glu Phe Gln Arg Asn Leu Lys Thr Leu Glu Asn Leu Pro
1025                1030                1035                1040
Asp Glu Lys Glu Pro Ile Ser Ile Thr Pro Pro Pro Ser Leu Gln Tyr
                1045                1050                1055    
Ser Leu Pro Gly Ala Leu Pro Ile Ser Gly Gln Pro Leu Thr Lys Cys
            1060                1065                1070        
Ile His Leu Thr Pro Gln Gln Ala Gln Glu Val Gly Ile Thr Leu Thr
        1075                1080                1085            
Pro Gln Gln Ala Gln Ala Gln Gly Ile Thr Leu Thr Leu Gln Gln Ala
    1090                1095                1100                
Gln Glu Leu Gly Ile Pro Leu Thr Pro Gln Gln Ala Gln Ala Leu Glu
1105                1110                1115                1120
Ile Leu Phe Thr Pro Gln Gln Ala Gln Ala Leu Gly Ile Pro Leu Thr
                1125                1130                1135    
Pro Gln Gln Thr Gln Val Gln Gly Ile Thr Leu Thr Pro Gln Gln Asp
            1140                1145                1150        
Gln Ala Pro Gly Ile Ser Leu Thr Thr Gln Gln Ala Gln Lys Leu Gly
        1155                1160                1165            
Ile Pro Leu Thr Pro Gln Gln Ala Gln Ala Leu Gly Ile Pro Leu Thr
    1170                1175                1180                
Pro Gln Gln Ala Gln Glu Leu Gly Ile Pro Leu Thr Pro Gln Gln Ala
1185                1190                1195                1200
Gln Ala Leu Arg Val Ser Leu Thr Pro Gln Gln Ala Gln Glu Leu Gly
                1205                1210                1215    
Ile Pro Leu Thr Pro Gln Gln Ala Gln Ala Leu Gly Ile Thr Leu Thr
            1220                1225                1230        
Leu Gln Gln Ala Gln Gln Leu Gly Ile Pro Leu Thr Pro Gln Gln Ala
        1235                1240                1245            
Gln Ala Leu Gly Ile Thr Leu Thr Pro Lys Gln Val Gln Glu Leu Gly
    1250                1255                1260                
Ile Pro Leu Thr Pro Gln Gln Ala Gln Ala Leu Gly Ile Thr Leu Thr
1265                1270                1275                1280
Pro Lys Gln Ala Gln Glu Leu Gly Ile Pro Leu Asn Pro Gln Gln Ala
                1285                1290                1295    
Gln Thr Leu Gly Ile Pro Leu Thr Pro Lys Gln Ala Gln Ala Leu Gly
            1300                1305                1310        
Ile Pro Phe Thr Pro Gln Gln Ala Gln Ala Leu Gly Ile Pro Leu Thr
        1315                1320                1325            
Pro Gln Gln Ala Gln Thr Gln Glu Ile Thr Leu Thr Pro Gln Gln Ala
    1330                1335                1340                
Gln Ala Leu Gly Met Pro Leu Thr Thr Gln Gln Ala Gln Glu Leu Gly
1345                1350                1355                1360
Ile Pro Leu Thr Pro Gln His Ala Gln Ala Leu Gly Met Pro Leu Thr
                1365                1370                1375    
Thr Gln Gln Ala Gln Glu Leu Gly Ile Pro Leu Thr Pro Gln Gln Ala
            1380                1385                1390        
Gln Ala Leu Gly Met Pro Leu Thr Thr Gln Gln Ala Gln Glu Leu Gly
        1395                1400                1405            
Ile Pro Leu Thr Pro Gln Gln Ala Gln Glu Leu Gly Ile Pro Phe Thr
    1410                1415                1420                
Pro Gln Gln Ala Gln Ala Gln Glu Ile Thr Leu Thr Pro Gln Gln Ala
1425                1430                1435                1440
Gln Ala Leu Gly Met Pro Leu Thr Ala Gln Gln Ala Gln Glu Leu Gly
                1445                1450                1455    
Ile Thr Leu Thr Pro Gln Gln Ala Gln Glu Leu Gly Ile Pro Leu Thr
            1460                1465                1470        
Pro Gln Gln Ala Gln Ala Leu Gly Ile Pro Leu Ile Pro Pro Gln Ala
        1475                1480                1485            
Gln Glu Leu Gly Ile Pro Leu Thr Pro Gln Gln Ala Gln Ala Leu Gly
    1490                1495                1500                
Ile Leu Leu Ile Pro Pro Gln Ala Gln Glu Leu Gly Ile Pro Leu Thr
1505                1510                1515                1520
Pro Gln Gln Ala Gln Ala Leu Gly Ile Pro Leu Ile Pro Pro Gln Ala
                1525                1530                1535    
Gln Glu Leu Gly Ile Pro Leu Thr Pro Gln Gln Val Gln Ala Leu Gly
            1540                1545                1550        
Ile Pro Leu Ile Pro Pro Gln Ala Gln Glu Leu Glu Ile Pro Leu Thr
        1555                1560                1565            
Pro Gln Gln Ala Gln Ala Leu Gly Ile Pro Leu Thr Pro Gln Gln Ala
    1570                1575                1580                
Gln Glu Leu Gly Ile Pro Leu Thr Pro Gln Gln Ala Gln Glu Leu Gly
1585                1590                1595                1600
Ile Pro Leu Thr Pro Gln Gln Ala Gln Ala Gln Gly Ile Pro Leu Thr
                1605                1610                1615    
Pro Gln Gln Ala Gln Ala Leu Gly Ile Ser Leu Thr Pro Gln Gln Ala
            1620                1625                1630        
Gln Ala Gln Gly Ile Thr Leu Thr Pro Gln Gln Ala Gln Ala Leu Gly
        1635                1640                1645            
Val Pro Ile Thr Pro Val Asn Ala Trp Val Ser Ala Val Thr Leu Thr
    1650                1655                1660                
Ser Glu Gln Thr His Ala Leu Glu Ser Pro Met Asn Leu Glu Gln Ala
1665                1670                1675                1680
Gln Glu Gln Leu Leu Lys Leu Gly Val Pro Leu Thr Leu Asp Lys Ala
                1685                1690                1695    
His Thr Leu Gly Ser Pro Leu Thr Leu Lys Gln Val Gln Trp Ser His
            1700                1705                1710        
Arg Pro Phe Gln Lys Ser Lys Ala Ser Leu Pro Thr Gly Gln Ser Ile
        1715                1720                1725            
Ile Ser Arg Leu Ser Pro Ser Leu Arg Leu Ser Leu Ala Ser Ser Ala
    1730                1735                1740                
Pro Thr Ala Glu Lys Ser Ser Ile Phe Gly Val Ser Ser Thr Pro Leu
1745                1750                1755                1760
Gln Ile Ser Arg Val Pro Leu Asn Gln Gly Pro Phe Ala Pro Gly Lys
                1765                1770                1775    
Pro Leu Glu Met Gly Ile Leu Ser Glu Pro Gly Lys Leu Gly Ala Pro
            1780                1785                1790        
Gln Thr Leu Arg Ser Ser Gly Gln Thr Leu Val Tyr Gly Gly Gln Ser
        1795                1800                1805            
Thr Ser Ala Gln Phe Pro Ala Pro Gln Ala Pro Pro Ser Pro Gly Gln
    1810                1815                1820                
Leu Pro Ile Ser Arg Ala Pro Pro Thr Pro Gly Gln Pro Phe Ile Ala
1825                1830                1835                1840
Gly Val Pro Pro Thr Ser Gly Gln Ile Pro Ser Leu Trp Ala Pro Leu
                1845                1850                1855    
Ser Pro Gly Gln Pro Leu Val Pro Glu Ala Ser Ser Ile Pro Gly Asp
            1860                1865                1870        
Leu Leu Glu Ser Gly Pro Leu Thr Phe Ser Glu Gln Leu Gln Glu Phe
        1875                1880                1885            
Gln Pro Pro Ala Thr Ala Glu Gln Ser Pro Tyr Leu Gln Ala Pro Ser
    1890                1895                1900                
Thr Pro Gly Gln His Leu Ala Thr Trp Thr Leu Pro Gly Arg Ala Ser
1905                1910                1915                1920
Ser Leu Trp Ile Pro Pro Thr Ser Arg His Pro Pro Thr Leu Trp Pro
                1925                1930                1935    
Ser Pro Ala Pro Gly Lys Pro Gln Lys Ser Trp Ser Pro Ser Val Ala
            1940                1945                1950        
Lys Lys Arg Leu Ala Ile Ile Ser Ser Leu Lys Ser Lys Ser Val Leu
        1955                1960                1965            
Ile His Pro Ser Ala Pro Asp Phe Lys Val Ala Gln Val Pro Phe Thr
    1970                1975                1980                
Thr Lys Lys Phe Gln Met Ser Glu Val Ser Asp Thr Ser Glu Glu Thr
1985                1990                1995                2000
Gln Ile Leu Arg Asp Thr Phe Ala Ile Glu Ser Phe Arg Thr Phe Gln
                2005                2010                2015    
Ser His Phe Thr Lys Tyr Arg Thr Pro Val Tyr Gln Thr Pro Tyr Thr
            2020                2025                2030        
Asp Glu Arg Ala Leu Leu Thr Leu Met Lys Pro Thr Thr Ser Pro Ser
        2035                2040                2045            
Ser Leu Thr Thr Leu Leu Arg Thr Ser Gln Ile Ser Pro Leu Glu Trp
    2050                2055                2060                
Tyr Gln Lys Ser Arg Phe Pro Pro Ile Asp Lys Pro Trp Ile Leu Ser
2065                2070                2075                2080
Ser Val Ser Asp Thr Lys Lys Pro Lys Val Met Val Pro Pro Ser Ser
                2085                2090                2095    
Pro Gln Glu Leu Glu Glu Lys Arg Tyr Phe Val Asp Val Glu Ala Gln
            2100                2105                2110        
Lys Lys Asn Leu Ile Leu Leu Asn Gln Ala Ile Lys Thr Cys Gly Leu
        2115                2120                2125            
Pro Ser Gln Leu His Thr Met Ala Arg Thr Leu Ile Ile Glu Ile Leu
    2130                2135                2140                
His Met Asp Thr Val Gln Leu Gly Tyr Leu Phe Arg Lys Tyr Ile Ala
2145                2150                2155                2160
Tyr Arg Leu Ile Gln His Ala Arg Asn Asn Ile Met Lys Arg Leu Lys
                2165                2170                2175    
Ala Ile Gln Asn Thr Gly Lys Gly Tyr Glu Ala Arg Asn Leu His Met
            2180                2185                2190        
Met Leu Ser Arg Leu Asp Asp Tyr Gly Lys Lys Val Met Gln Val Trp
        2195                2200                2205            
Thr Glu Lys Gln Lys Ser Leu Gly Gln Lys Arg Asn Gln Cys Leu Lys
    2210                2215                2220                
Lys Met Ile His Val Phe Asn Gln Leu Lys Lys Ile His Glu Leu Asn
2225                2230                2235                2240
Leu Ser Gln Pro Ile Pro Leu Ile Ile Glu Glu Lys Gln Ile Pro Ala
                2245                2250                2255    
Ser Thr Thr Phe Val Gln Lys Pro Phe Leu Lys Leu Leu Met Glu Glu
            2260                2265                2270        
Asp Arg Thr Ser Asp Ile Cys Lys Lys Phe Arg Gln Gln Glu Asp Gln
        2275                2280                2285            
Thr Glu Ala Ile Trp Asn Val Asp Leu Ser Thr Ser Ser Tyr Pro Ile
    2290                2295                2300                
Ala Glu Lys Thr Ser Met His Ser Leu Trp Ala Gln Leu Gly Gly Tyr
2305                2310                2315                2320
Pro Asp Ile Pro Arg Leu Leu Gln Leu Glu Val Gln Ser Thr Phe Arg
                2325                2330                2335    
Lys Ser Leu Ala Ser Leu Gln Ser Arg Val Lys Lys Ile Pro Lys
            2340                2345                2350    


<210> 5770
<211> 141
<212> PRT
<213> Homo sapiens

<400> 5770
Met Ala Cys Thr Tyr Val Ser Asn Leu Gly Lys Lys Gln Arg Ser Val
 1               5                  10                  15      
Ser Phe Leu Ala Ser Gly Leu Met Arg Val Ser Thr Gly Pro Glu Leu
            20                  25                  30          
Arg Leu His His Ser Phe Val Leu Thr Gly Asp Val Gly Arg Arg Ile
        35                  40                  45              
Cys Arg Leu Leu Val Gly Leu Phe Thr Lys Gly Asp Thr Ser Ser Lys
    50                  55                  60                  
Arg Val His Pro Phe Ser Pro Gly Pro Cys Phe Leu Leu Cys Asp Leu
65                  70                  75                  80  
Ala Arg Val Gly Ser Ser Pro Lys Ile Asn Val Ser Pro Phe Tyr Gln
                85                  90                  95      
Asn Gln Thr Ser Thr Gln Arg Ser Cys Thr Val Phe Val Trp Gln Arg
            100                 105                 110         
Cys Ser Leu Val Gly Pro Phe Gln Val Thr Val Phe Thr Met Tyr Phe
        115                 120                 125             
His His Ser Leu Arg Ser Ile Ser Arg Phe Ser Ser Gly
    130                 135                 140     


<210> 5771
<211> 461
<212> PRT
<213> Homo sapiens

<400> 5771
Met Glu Gly Ser Lys Thr Ser Asn Asn Ser Thr Met Gln Val Ser Phe
 1               5                  10                  15      
Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Thr Ser Phe Lys
            20                  25                  30          
Ile Leu Asp Arg Val Thr Ile Gln Glu Leu Thr Ala Pro Leu Leu Thr
        35                  40                  45              
Thr Ala Gln Ala Lys Pro Gly Glu Thr Gln Glu Glu Glu Thr Asn Ser
    50                  55                  60                  
Gly Glu Glu Pro Phe Ile Glu Thr Pro Arg Gln Asp Gly Val Ser Arg
65                  70                  75                  80  
Arg Phe Ile Pro Pro Ala Arg Met Met Ser Thr Glu Ser Ala Asn Ser
                85                  90                  95      
Phe Thr Leu Ile Gly Glu Ala Ser Asp Gly Gly Thr Met Glu Asn Leu
            100                 105                 110         
Ser Arg Arg Leu Lys Ala Ser Pro Thr Leu Thr Leu Pro His Phe Gln
        115                 120                 125             
Val Thr Gly Asp Leu Phe Asp Ile Met Ser Gly Gln Thr Asp Val Asp
    130                 135                 140                 
His Pro Leu Cys Glu Glu Cys Thr Asp Thr Leu Leu Asp Gln Leu Asp
145                 150                 155                 160 
Thr Gln Leu Asn Val Thr Glu Asn Glu Cys Gln Asn Tyr Lys Arg Cys
                165                 170                 175     
Leu Glu Ile Leu Glu Gln Met Asn Glu Asp Asp Ser Glu Gln Leu Gln
            180                 185                 190         
Met Glu Leu Lys Glu Leu Ala Leu Glu Glu Glu Arg Leu Ile Gln Glu
        195                 200                 205             
Leu Glu Asp Val Glu Lys Asn Arg Lys Ile Val Ala Glu Asn Leu Glu
    210                 215                 220                 
Lys Val Gln Ala Glu Ala Glu Arg Leu Asp Gln Glu Glu Ala Gln Tyr
225                 230                 235                 240 
Gln Arg Glu Tyr Ser Glu Phe Lys Arg Gln Gln Leu Glu Leu Asp Asp
                245                 250                 255     
Glu Leu Lys Ser Val Glu Asn Gln Met Arg Tyr Ala Gln Thr Gln Leu
            260                 265                 270         
Asp Lys Leu Lys Lys Thr Asn Val Phe Asn Ala Thr Phe His Ile Trp
        275                 280                 285             
His Ser Gly Gln Phe Gly Thr Ile Asn Asn Phe Arg Leu Gly Arg Leu
    290                 295                 300                 
Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn Ala Ala Trp Gly Gln
305                 310                 315                 320 
Thr Val Leu Leu Leu His Ala Leu Ala Asn Lys Met Gly Leu Lys Phe
                325                 330                 335     
Gln Arg Tyr Arg Leu Val Pro Tyr Gly Asn His Ser Tyr Leu Glu Ser
            340                 345                 350         
Leu Thr Asp Lys Ser Lys Glu Leu Pro Leu Tyr Cys Ser Gly Gly Leu
        355                 360                 365             
Arg Phe Phe Trp Asp Asn Lys Phe Asp His Ala Met Val Ala Phe Leu
    370                 375                 380                 
Asp Cys Val Gln Gln Phe Lys Glu Glu Val Glu Lys Gly Glu Thr Arg
385                 390                 395                 400 
Phe Cys Leu Pro Tyr Arg Met Asp Val Glu Lys Gly Lys Ile Glu Asp
                405                 410                 415     
Thr Gly Gly Ser Gly Gly Ser Tyr Ser Ile Lys Thr Gln Phe Asn Ser
            420                 425                 430         
Glu Glu Gln Trp Thr Lys Ala Leu Lys Phe Met Leu Thr Asn Leu Lys
        435                 440                 445             
Trp Gly Leu Ala Trp Val Ser Ser Gln Phe Tyr Asn Lys
    450                 455                 460     


<210> 5772
<211> 548
<212> PRT
<213> Homo sapiens

<400> 5772
Met Ala Thr Ser Ser Glu Glu Val Leu Leu Ile Val Lys Lys Val Arg
 1               5                  10                  15      
Gln Lys Lys Gln Asp Gly Ala Leu Tyr Leu Met Ala Glu Arg Ile Ala
            20                  25                  30          
Trp Ala Pro Glu Gly Lys Asp Arg Phe Thr Ile Ser His Met Tyr Ala
        35                  40                  45              
Asp Ile Lys Cys Gln Lys Ile Ser Pro Glu Gly Lys Ala Lys Ile Gln
    50                  55                  60                  
Leu Gln Leu Val Leu His Ala Gly Asp Thr Thr Asn Phe His Phe Ser
65                  70                  75                  80  
Asn Glu Ser Thr Ala Val Lys Glu Arg Asp Ala Val Lys Asp Leu Leu
                85                  90                  95      
Gln Gln Leu Leu Pro Lys Phe Lys Arg Lys Ala Asn Lys Glu Leu Glu
            100                 105                 110         
Glu Lys Asn Arg Met Leu Gln Glu Asp Pro Val Leu Phe Gln Leu Tyr
        115                 120                 125             
Lys Asp Leu Val Val Ser Gln Val Ile Ser Ala Glu Glu Phe Trp Ala
    130                 135                 140                 
Asn Arg Leu Asn Val Asn Ala Thr Asp Ser Ser Ser Thr Ser Asn His
145                 150                 155                 160 
Lys Gln Asp Val Gly Ile Ser Ala Ala Phe Leu Ala Asp Val Arg Pro
                165                 170                 175     
Gln Thr Asp Gly Cys Asn Gly Leu Arg Tyr Asn Leu Thr Ser Asp Ile
            180                 185                 190         
Ile Glu Ser Ile Phe Arg Thr Tyr Pro Ala Val Lys Met Lys Tyr Ala
        195                 200                 205             
Glu Asn Val Pro His Asn Met Thr Glu Lys Glu Phe Trp Thr Arg Phe
    210                 215                 220                 
Phe Gln Ser His Tyr Phe His Arg Asp Arg Leu Asn Thr Gly Ser Lys
225                 230                 235                 240 
Asp Leu Phe Ala Glu Cys Ala Lys Ile Asp Glu Lys Gly Leu Lys Thr
                245                 250                 255     
Met Val Ser Leu Gly Val Lys Asn Pro Leu Leu Asp Leu Thr Ala Leu
            260                 265                 270         
Glu Asp Lys Pro Leu Asp Glu Gly Tyr Gly Ile Ser Ser Val Pro Ser
        275                 280                 285             
Ala Ser Asn Ser Lys Ser Ile Lys Glu Asn Ser Asn Ala Ala Ile Ile
    290                 295                 300                 
Lys Arg Phe Asn His His Ser Ala Met Val Leu Ala Ala Gly Leu Arg
305                 310                 315                 320 
Lys Gln Glu Ala Gln Asn Glu Gln Thr Ser Glu Pro Ser Asn Met Asp
                325                 330                 335     
Gly Asn Ser Gly Asp Ala Asp Cys Phe Gln Pro Ala Val Lys Arg Ala
            340                 345                 350         
Lys Leu Gln Glu Ser Ile Glu Tyr Glu Asp Leu Gly Lys Asn Asn Ser
        355                 360                 365             
Val Lys Thr Ile Ala Leu Asn Leu Lys Lys Ser Asp Arg Tyr Tyr His
    370                 375                 380                 
Gly Pro Thr Pro Ile Gln Ser Leu Gln Tyr Ala Thr Ser Gln Asp Ile
385                 390                 395                 400 
Ile Asn Ser Phe Gln Ser Ile Arg Gln Glu Met Glu Ala Tyr Thr Pro
                405                 410                 415     
Lys Leu Thr Gln Val Leu Ser Ser Ser Ala Ala Ser Ser Thr Ile Thr
            420                 425                 430         
Ala Leu Ser Pro Gly Gly Ala Leu Met Gln Gly Gly Thr Gln Gln Ala
        435                 440                 445             
Ile Asn Gln Met Val Pro Asn Asp Ile Gln Ser Glu Leu Lys His Leu
    450                 455                 460                 
Tyr Val Ala Val Gly Glu Leu Leu Arg His Phe Trp Ser Cys Phe Pro
465                 470                 475                 480 
Val Asn Thr Pro Phe Leu Glu Glu Lys Val Val Lys Met Lys Ser Asn
                485                 490                 495     
Leu Glu Arg Phe Gln Val Thr Lys Leu Cys Pro Phe Gln Glu Lys Ile
            500                 505                 510         
Arg Arg Gln Tyr Leu Ser Thr Asn Leu Val Ser His Ile Glu Glu Met
        515                 520                 525             
Leu Gln Thr Ala Tyr Asn Lys Leu His Thr Trp Gln Ser Arg Arg Leu
    530                 535                 540                 
Met Lys Lys Thr
545             


<210> 5773
<211> 842
<212> PRT
<213> Homo sapiens

<400> 5773
Met Ser Arg Pro Leu Ser Asp Gln Glu Lys Arg Lys Gln Ile Ser Val
 1               5                  10                  15      
Arg Gly Leu Ala Gly Val Glu Asn Val Thr Glu Leu Lys Lys Asn Phe
            20                  25                  30          
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr
        35                  40                  45              
Pro Arg Asp Tyr Tyr Phe Ala Leu Ala His Thr Val Arg Asp His Leu
    50                  55                  60                  
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Lys Asp Pro
65                  70                  75                  80  
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu
                85                  90                  95      
Gln Asn Thr Met Val Asn Leu Ala Leu Glu Asn Ala Cys Asp Glu Ala
            100                 105                 110         
Thr Tyr Gln Leu Gly Leu Asp Met Glu Glu Leu Glu Glu Ile Glu Glu
        115                 120                 125             
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe
    130                 135                 140                 
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile
145                 150                 155                 160 
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Ser Gly Gly Trp Gln
                165                 170                 175     
Met Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys
            180                 185                 190         
Ala Arg Pro Glu Phe Thr Leu Pro Val His Phe Tyr Gly His Val Glu
        195                 200                 205             
His Thr Ser Gln Gly Ala Lys Trp Val Asp Thr Gln Val Val Leu Ala
    210                 215                 220                 
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Arg Asn Asn Val Val Asn
225                 230                 235                 240 
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Asn Leu Lys
                245                 250                 255     
Asp Phe Asn Val Gly Gly Tyr Ile Gln Ala Val Leu Asp Arg Asn Leu
            260                 265                 270         
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu
        275                 280                 285             
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr
    290                 295                 300                 
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg
305                 310                 315                 320 
Asp Pro Val Arg Thr Asn Phe Asp Ala Phe Pro Asp Lys Val Ala Ile
                325                 330                 335     
Gln Leu Asn Asp Thr His Pro Ser Leu Ala Ile Pro Glu Leu Met Arg
            340                 345                 350         
Ile Leu Val Asp Leu Glu Arg Met Asp Trp Asp Lys Ala Trp Asp Val
        355                 360                 365             
Thr Val Arg Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala
    370                 375                 380                 
Leu Glu Arg Trp Pro Val His Leu Leu Glu Thr Leu Leu Pro Arg His
385                 390                 395                 400 
Leu Gln Ile Ile Tyr Glu Ile Asn Gln Arg Phe Leu Asn Arg Val Ala
                405                 410                 415     
Ala Ala Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Leu Val
            420                 425                 430         
Glu Glu Gly Ala Val Lys Arg Ile Asn Met Ala His Leu Cys Ile Ala
        435                 440                 445             
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Leu
    450                 455                 460                 
Lys Lys Thr Ile Phe Lys Asp Phe Tyr Glu Leu Glu Pro His Lys Phe
465                 470                 475                 480 
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Val Leu Cys
                485                 490                 495     
Asn Pro Gly Leu Ala Glu Val Ile Ala Glu Arg Ile Gly Glu Asp Phe
            500                 505                 510         
Ile Ser Asp Leu Asp Gln Leu Arg Lys Leu Leu Ser Phe Val Asp Asp
        515                 520                 525             
Glu Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu
    530                 535                 540                 
Lys Phe Ala Ala Tyr Leu Glu Arg Glu Tyr Lys Val His Ile Asn Pro
545                 550                 555                 560 
Asn Ser Leu Phe Asp Ile Gln Val Lys Arg Ile His Glu Tyr Lys Arg
                565                 570                 575     
Gln Leu Leu Asn Cys Leu His Val Ile Thr Leu Tyr Asn Arg Ile Lys
            580                 585                 590         
Arg Glu Pro Asn Lys Phe Phe Val Pro Arg Thr Val Met Ile Gly Gly
        595                 600                 605             
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Arg Leu Val
    610                 615                 620                 
Thr Ala Ile Gly Asp Val Val Asn His Asp Pro Ala Val Gly Asp Arg
625                 630                 635                 640 
Leu Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys
                645                 650                 655     
Val Ile Pro Ala Ala Asp Leu Ser Glu Gln Ile Ser Thr Ala Gly Thr
            660                 665                 670         
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu
        675                 680                 685             
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala
    690                 695                 700                 
Gly Glu Glu Asn Phe Phe Ile Phe Gly Met Arg Val Glu Asp Val Asp
705                 710                 715                 720 
Lys Leu Asp Gln Arg Gly Tyr Asn Ala Gln Glu Tyr Tyr Asp Arg Ile
                725                 730                 735     
Pro Glu Leu Arg Gln Val Ile Glu Gln Leu Ser Ser Gly Phe Phe Ser
            740                 745                 750         
Pro Lys Gln Pro Asp Leu Phe Lys Asp Ile Val Asn Met Leu Met His
        755                 760                 765             
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Asp Tyr Ile Lys Cys
    770                 775                 780                 
Gln Glu Lys Val Ser Ala Leu Tyr Lys Asn Pro Arg Glu Trp Thr Arg
785                 790                 795                 800 
Met Val Ile Arg Asn Ile Ala Thr Ser Gly Lys Phe Ser Ser Asp Arg
                805                 810                 815     
Thr Ile Ala Gln Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Arg
            820                 825                 830         
Gln Arg Leu Pro Ala Pro Asp Glu Ala Ile
        835                 840         


<210> 5774
<211> 126
<212> PRT
<213> Homo sapiens

<400> 5774
Met Val Glu Ile Ser Leu Lys Ser Val Ile Ser His Arg Ala Ser Lys
 1               5                  10                  15      
Gly Asp Cys Ile Pro Val Val His Ser Leu Gln Ala Ala Pro Gln Val
            20                  25                  30          
Ser Glu Pro Gln Ser Val Val Ile Gly Glu Ser Ser Asp Cys Glu Arg
        35                  40                  45              
Trp Trp Arg Pro Leu Ser Met Val Glu Ala Arg Gly Ser Leu Ser Thr
    50                  55                  60                  
Gly Ser Cys Val Pro Ser Asn Ser Ser His Pro Ala Trp Phe Thr Pro
65                  70                  75                  80  
Arg Glu Pro Ser Asp Pro Thr Ser Asn Arg Ser Thr Phe His Pro Gly
                85                  90                  95      
Asp Ser Gln Lys Pro Val Lys Arg Pro Gly Ala Thr Ser Ile Ser Arg
            100                 105                 110         
Thr Ala Ser Leu Pro Leu Leu Gln Ser Pro Leu Cys Pro Ser
        115                 120                 125     


<210> 5775
<211> 1638
<212> PRT
<213> Homo sapiens

<400> 5775
Ser Arg Ser Leu Gln Gly Pro Ser Ile Ile Glu Cys Thr Ala Ser Gly
 1               5                  10                  15      
Ile Trp Asp Arg Ala Pro Pro Ala Cys His Leu Val Phe Cys Gly Glu
            20                  25                  30          
Pro Pro Ala Ile Lys Asp Ala Val Ile Thr Gly Asn Asn Phe Thr Phe
        35                  40                  45              
Arg Asn Thr Val Thr Tyr Thr Cys Lys Glu Gly Tyr Thr Leu Ala Gly
    50                  55                  60                  
Leu Asp Thr Ile Glu Cys Leu Ala Asp Gly Lys Trp Ser Arg Ser Asp
65                  70                  75                  80  
Gln Gln Cys Leu Ala Val Ser Cys Asp Glu Pro Pro Ile Val Asp His
                85                  90                  95      
Ala Ser Pro Glu Thr Ala His Arg Leu Phe Gly Asp Ile Ala Phe Tyr
            100                 105                 110         
Tyr Cys Ser Asp Gly Tyr Ser Leu Ala Asp Asn Ser Gln Leu Leu Cys
        115                 120                 125             
Asn Ala Gln Gly Lys Trp Val Pro Pro Glu Gly Gln Asp Met Pro Arg
    130                 135                 140                 
Cys Ile Ala His Phe Cys Glu Lys Pro Pro Ser Val Ser Tyr Ser Ile
145                 150                 155                 160 
Leu Glu Ser Val Ser Lys Ala Lys Phe Ala Ala Gly Ser Val Val Ser
                165                 170                 175     
Phe Lys Cys Met Glu Gly Phe Val Leu Asn Thr Ser Ala Lys Ile Glu
            180                 185                 190         
Cys Met Arg Gly Gly Gln Trp Asn Pro Ser Pro Met Ser Ile Gln Cys
        195                 200                 205             
Ile Pro Val Arg Cys Gly Glu Pro Pro Ser Ile Met Asn Gly Tyr Ala
    210                 215                 220                 
Ser Gly Ser Asn Tyr Ser Phe Gly Ala Met Val Ala Tyr Ser Cys Asn
225                 230                 235                 240 
Lys Gly Phe Tyr Ile Lys Gly Glu Lys Lys Ser Thr Cys Glu Ala Thr
                245                 250                 255     
Gly Gln Trp Ser Ser Pro Ile Pro Thr Cys His Pro Val Ser Cys Gly
            260                 265                 270         
Glu Pro Pro Lys Val Glu Asn Gly Phe Leu Glu His Thr Thr Gly Arg
        275                 280                 285             
Ile Phe Glu Ser Glu Val Arg Tyr Gln Cys Asn Pro Gly Tyr Lys Ser
    290                 295                 300                 
Val Gly Ser Pro Val Phe Val Cys Gln Ala Asn Arg His Trp His Ser
305                 310                 315                 320 
Glu Ser Pro Leu Met Cys Val Pro Leu Asp Cys Gly Lys Pro Pro Pro
                325                 330                 335     
Ile Gln Asn Gly Phe Met Lys Gly Glu Asn Phe Glu Val Gly Ser Lys
            340                 345                 350         
Val Gln Phe Phe Cys Asn Glu Gly Tyr Glu Leu Val Gly Asp Ser Ser
        355                 360                 365             
Trp Thr Cys Gln Lys Ser Gly Lys Trp Asn Lys Lys Ser Asn Pro Lys
    370                 375                 380                 
Cys Met Pro Ala Lys Cys Pro Glu Pro Pro Leu Leu Glu Asn Gln Leu
385                 390                 395                 400 
Val Leu Lys Glu Leu Thr Thr Glu Val Gly Val Val Thr Phe Ser Cys
                405                 410                 415     
Lys Glu Gly His Val Leu Gln Gly Pro Ser Val Leu Lys Cys Leu Pro
            420                 425                 430         
Ser Gln Gln Trp Asn Asp Ser Phe Pro Val Cys Lys Ile Val Leu Cys
        435                 440                 445             
Thr Pro Pro Pro Leu Ile Ser Phe Gly Val Pro Ile Pro Ser Ser Ala
    450                 455                 460                 
Leu His Phe Gly Ser Thr Val Lys Tyr Ser Cys Val Gly Gly Phe Phe
465                 470                 475                 480 
Leu Arg Gly Asn Ser Thr Thr Leu Cys Gln Pro Asp Gly Thr Trp Ser
                485                 490                 495     
Ser Pro Leu Pro Glu Cys Val Pro Val Glu Cys Pro Gln Pro Glu Glu
            500                 505                 510         
Ile Pro Asn Gly Ile Ile Asp Val Gln Gly Leu Ala Tyr Leu Ser Thr
        515                 520                 525             
Ala Leu Tyr Thr Cys Lys Pro Gly Phe Glu Leu Val Gly Asn Thr Thr
    530                 535                 540                 
Thr Leu Cys Gly Glu Asn Gly His Trp Leu Gly Gly Lys Pro Thr Cys
545                 550                 555                 560 
Lys Ala Ile Glu Cys Leu Lys Pro Lys Glu Ile Leu Asn Gly Lys Phe
                565                 570                 575     
Ser Tyr Thr Asp Leu His Tyr Gly Gln Thr Val Thr Tyr Ser Cys Asn
            580                 585                 590         
Arg Gly Phe Arg Leu Glu Gly Pro Ser Ala Leu Thr Cys Leu Glu Thr
        595                 600                 605             
Gly Asp Trp Asp Val Asp Ala Pro Ser Cys Asn Ala Ile His Cys Asp
    610                 615                 620                 
Ser Pro Gln Pro Ile Glu Asn Gly Phe Val Glu Gly Ala Asp Tyr Ser
625                 630                 635                 640 
Tyr Gly Ala Ile Ile Ile Tyr Ser Cys Phe Pro Gly Phe Gln Val Ala
                645                 650                 655     
Gly His Ala Met Gln Thr Cys Glu Glu Ser Gly Trp Ser Ser Ser Ile
            660                 665                 670         
Pro Thr Cys Met Pro Ile Asp Cys Gly Leu Pro Pro His Ile Asp Phe
        675                 680                 685             
Gly Asp Cys Thr Lys Leu Lys Asp Asp Gln Gly Tyr Phe Glu Gln Glu
    690                 695                 700                 
Asp Asp Met Met Glu Val Pro Tyr Val Thr Pro His Pro Pro Tyr His
705                 710                 715                 720 
Leu Gly Ala Val Ala Lys Thr Trp Glu Asn Thr Lys Glu Ser Pro Ala
                725                 730                 735     
Thr His Ser Ser Asn Phe Leu Tyr Gly Thr Met Val Ser Tyr Thr Cys
            740                 745                 750         
Asn Pro Gly Tyr Glu Leu Leu Gly Asn Pro Val Leu Ile Cys Gln Glu
        755                 760                 765             
Asp Gly Thr Trp Asn Gly Ser Ala Pro Ser Cys Ile Ser Ile Glu Cys
    770                 775                 780                 
Asp Leu Pro Thr Ala Pro Glu Asn Gly Phe Leu Arg Phe Thr Glu Thr
785                 790                 795                 800 
Ser Met Gly Ser Ala Val Gln Tyr Ser Cys Lys Pro Gly His Ile Leu
                805                 810                 815     
Ala Gly Ser Asp Leu Arg Leu Cys Leu Glu Asn Arg Lys Trp Ser Gly
            820                 825                 830         
Ala Ser Pro Arg Cys Glu Ala Ile Ser Cys Lys Lys Pro Asn Pro Val
        835                 840                 845             
Met Asn Gly Ser Ile Lys Gly Ser Asn Tyr Thr Tyr Leu Ser Thr Leu
    850                 855                 860                 
Tyr Tyr Glu Cys Asp Pro Gly Tyr Val Leu Asn Gly Thr Glu Arg Arg
865                 870                 875                 880 
Thr Cys Gln Asp Asp Lys Asn Trp Asp Glu Asp Glu Pro Ile Cys Ile
                885                 890                 895     
Pro Val Asp Cys Ser Ser Pro Pro Val Ser Ala Asn Gly Gln Val Arg
            900                 905                 910         
Gly Asp Glu Tyr Thr Phe Gln Lys Glu Ile Glu Tyr Thr Cys Asn Glu
        915                 920                 925             
Gly Phe Leu Leu Glu Gly Ala Arg Ser Arg Val Cys Leu Ala Asn Gly
    930                 935                 940                 
Ser Trp Ser Gly Ala Thr Pro Asp Cys Val Pro Val Arg Cys Ala Thr
945                 950                 955                 960 
Pro Pro Gln Leu Ala Asn Gly Val Thr Glu Gly Leu Asp Tyr Gly Phe
                965                 970                 975     
Met Lys Glu Val Thr Phe His Cys His Glu Gly Tyr Ile Leu His Gly
            980                 985                 990         
Ala Pro Lys Leu Thr Cys Gln Ser Asp Gly Asn Trp Asp Ala Glu Ile
        995                 1000                1005            
Pro Leu Cys Lys Pro Val Asn Cys Gly Pro Pro Glu Asp Leu Ala His
    1010                1015                1020                
Gly Phe Pro Asn Gly Phe Ser Phe Ile His Gly Gly His Ile Gln Tyr
1025                1030                1035                1040
Gln Cys Phe Pro Gly Tyr Lys Leu His Gly Asn Ser Ser Arg Arg Cys
                1045                1050                1055    
Leu Ser Asn Gly Ser Trp Ser Gly Ser Ser Pro Ser Cys Leu Pro Cys
            1060                1065                1070        
Arg Cys Ser Thr Pro Val Ile Glu Tyr Gly Thr Val Asn Gly Thr Asp
        1075                1080                1085            
Phe Asp Cys Gly Lys Ala Ala Arg Ile Gln Cys Phe Lys Gly Phe Lys
    1090                1095                1100                
Leu Leu Gly Leu Ser Glu Ile Thr Cys Glu Ala Asp Gly Gln Trp Ser
1105                1110                1115                1120
Ser Gly Phe Pro His Cys Glu His Thr Ser Cys Gly Ser Leu Pro Met
                1125                1130                1135    
Ile Pro Asn Ala Phe Ile Ser Glu Thr Ser Ser Trp Lys Glu Asn Val
            1140                1145                1150        
Ile Thr Tyr Ser Cys Arg Ser Gly Tyr Val Ile Gln Gly Ser Ser Asp
        1155                1160                1165            
Leu Ile Cys Thr Glu Lys Gly Val Trp Ser Gln Pro Tyr Pro Val Cys
    1170                1175                1180                
Glu Pro Leu Ser Cys Gly Ser Pro Pro Ser Val Ala Asn Ala Val Ala
1185                1190                1195                1200
Thr Gly Glu Ala His Thr Tyr Glu Ser Glu Val Lys Leu Arg Cys Leu
                1205                1210                1215    
Glu Gly Tyr Thr Met Asp Thr Asp Thr Asp Thr Phe Thr Cys Gln Lys
            1220                1225                1230        
Asp Gly Arg Trp Phe Pro Glu Arg Ile Ser Cys Ser Pro Lys Lys Cys
        1235                1240                1245            
Pro Leu Pro Glu Asn Ile Thr His Ile Leu Val His Gly Asp Asp Phe
    1250                1255                1260                
Ser Val Asn Arg Gln Val Ser Val Ser Cys Ala Glu Gly Tyr Thr Phe
1265                1270                1275                1280
Glu Gly Val Asn Ile Ser Val Cys Gln Leu Asp Gly Thr Trp Glu Pro
                1285                1290                1295    
Pro Phe Ser Asp Glu Ser Cys Ser Pro Val Ser Cys Gly Lys Pro Glu
            1300                1305                1310        
Ser Pro Glu His Gly Phe Val Val Gly Ser Lys Tyr Thr Phe Glu Ser
        1315                1320                1325            
Thr Ile Ile Tyr Gln Cys Glu Pro Gly Tyr Glu Leu Glu Gly Asn Arg
    1330                1335                1340                
Glu Arg Val Cys Gln Glu Asn Arg Gln Trp Ser Gly Gly Val Ala Ile
1345                1350                1355                1360
Cys Lys Glu Thr Arg Cys Glu Thr Pro Leu Glu Phe Leu Asn Gly Lys
                1365                1370                1375    
Ala Asp Ile Glu Asn Arg Thr Thr Gly Pro Asn Val Val Tyr Ser Cys
            1380                1385                1390        
Asn Arg Gly Tyr Ser Leu Glu Gly Pro Ser Glu Ala His Cys Thr Glu
        1395                1400                1405            
Asn Gly Thr Trp Ser His Pro Val Pro Leu Cys Lys Pro Asn Pro Cys
    1410                1415                1420                
Pro Val Pro Phe Val Ile Pro Glu Asn Ala Leu Leu Ser Glu Lys Glu
1425                1430                1435                1440
Phe Tyr Val Asp Gln Asn Val Ser Ile Lys Cys Arg Glu Gly Phe Leu
                1445                1450                1455    
Leu Gln Gly His Gly Ile Ile Thr Cys Asn Pro Asp Glu Thr Trp Thr
            1460                1465                1470        
Gln Thr Ser Ala Lys Cys Glu Lys Ile Ser Cys Gly Pro Pro Ala His
        1475                1480                1485            
Val Glu Asn Ala Ile Ala Arg Gly Val His Tyr Gln Tyr Gly Asp Met
    1490                1495                1500                
Ile Thr Tyr Ser Cys Tyr Ser Gly Tyr Met Leu Glu Gly Phe Leu Arg
1505                1510                1515                1520
Ser Val Cys Leu Glu Asn Gly Thr Trp Thr Ser Pro Pro Ile Cys Arg
                1525                1530                1535    
Ala Val Cys Arg Phe Pro Cys Gln Asn Gly Gly Ile Cys Gln Arg Pro
            1540                1545                1550        
Asn Ala Cys Ser Cys Pro Glu Gly Trp Met Gly Arg Leu Cys Glu Glu
        1555                1560                1565            
Pro Ile Cys Ile Leu Pro Cys Leu Asn Gly Gly Arg Cys Val Ala Pro
    1570                1575                1580                
Tyr Gln Cys Asp Cys Pro Pro Gly Trp Thr Gly Ser Arg Cys His Thr
1585                1590                1595                1600
Ala Val Cys Gln Ser Pro Cys Leu Asn Gly Gly Lys Cys Val Arg Pro
                1605                1610                1615    
Asn Arg Cys His Cys Leu Ser Ser Trp Thr Gly His Asn Cys Ser Arg
            1620                1625                1630        
Lys Arg Arg Thr Gly Phe
        1635            


<210> 5776
<211> 457
<212> PRT
<213> Homo sapiens

<400> 5776
Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser
 1               5                  10                  15      
Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn
            20                  25                  30          
Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala
        35                  40                  45              
Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn
    50                  55                  60                  
Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met
65                  70                  75                  80  
Ser Pro Gly Ala Gly Ala Met Ala Gly Met Gly Gly Ser Ala Gly Ala
                85                  90                  95      
Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro
            100                 105                 110         
Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala
        115                 120                 125             
Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg
    130                 135                 140                 
Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro
145                 150                 155                 160 
Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro
                165                 170                 175     
Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu
            180                 185                 190         
Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg
        195                 200                 205             
His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro
    210                 215                 220                 
Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly
225                 230                 235                 240 
Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys
                245                 250                 255     
Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Gly Ser
            260                 265                 270         
Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala Ser Gln Ala Gln Leu Gly
        275                 280                 285             
Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro
    290                 295                 300                 
His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Gly
305                 310                 315                 320 
Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu Ser Pro Pro Glu Pro Ala
                325                 330                 335     
Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro
            340                 345                 350         
Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His
        355                 360                 365             
His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser
    370                 375                 380                 
Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met
385                 390                 395                 400 
Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Tyr Gly Ser
                405                 410                 415     
Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Thr Gly
            420                 425                 430         
Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly Val
        435                 440                 445             
Tyr Ser Arg Pro Ile Met Asn Ser Ser
    450                 455         


<210> 5777
<211> 429
<212> PRT
<213> Homo sapiens

<400> 5777
Met Thr Gly Lys Ser Val Lys Asp Val Asp Arg Tyr Gln Ala Val Leu
 1               5                  10                  15      
Ala Asn Leu Leu Leu Glu Glu Asp Asn Lys Phe Cys Ala Asp Cys Gln
            20                  25                  30          
Ser Lys Gly Pro Arg Trp Ala Ser Trp Asn Ile Gly Val Phe Ile Cys
        35                  40                  45              
Ile Arg Cys Ala Gly Ile His Arg Asn Leu Gly Val His Ile Ser Arg
    50                  55                  60                  
Val Lys Ser Val Asn Leu Asp Gln Trp Thr Gln Glu Gln Ile Gln Cys
65                  70                  75                  80  
Met Gln Glu Met Gly Asn Gly Lys Ala Asn Arg Leu Tyr Glu Ala Tyr
                85                  90                  95      
Leu Pro Glu Thr Phe Arg Arg Pro Gln Ile Asp Pro Ala Val Glu Gly
            100                 105                 110         
Phe Ile Arg Asp Lys Tyr Glu Lys Lys Lys Tyr Met Asp Arg Ser Leu
        115                 120                 125             
Asp Ile Asn Ala Phe Arg Lys Glu Lys Asp Asp Lys Trp Lys Arg Gly
    130                 135                 140                 
Ser Glu Pro Val Pro Glu Lys Lys Leu Glu Pro Val Val Phe Glu Lys
145                 150                 155                 160 
Val Lys Met Pro Gln Lys Lys Glu Asp Pro Gln Leu Pro Arg Lys Ser
                165                 170                 175     
Ser Pro Lys Ser Thr Ala Pro Val Met Asp Leu Leu Gly Leu Asp Ala
            180                 185                 190         
Pro Val Ala Cys Ser Ile Ala Asn Ser Lys Thr Ser Asn Thr Leu Glu
        195                 200                 205             
Lys Asp Leu Asp Leu Leu Ala Ser Val Pro Ser Pro Ser Ser Ser Gly
    210                 215                 220                 
Ser Arg Lys Val Val Gly Ser Met Pro Thr Ala Gly Ser Ala Gly Ser
225                 230                 235                 240 
Val Pro Glu Asn Leu Asn Leu Phe Pro Glu Pro Gly Ser Lys Ser Glu
                245                 250                 255     
Glu Ile Gly Lys Lys Gln Leu Ser Lys Asp Ser Ile Leu Ser Leu Tyr
            260                 265                 270         
Gly Ser Gln Thr Pro Gln Met Pro Thr Gln Ala Met Phe Met Ala Pro
        275                 280                 285             
Ala Gln Met Ala Tyr Pro Thr Ala Tyr Pro Ser Phe Pro Gly Val Thr
    290                 295                 300                 
Pro Pro Asn Ser Ile Met Gly Ser Met Met Pro Pro Pro Val Gly Met
305                 310                 315                 320 
Val Ala Gln Pro Gly Ala Ser Gly Met Val Ala Pro Met Ala Met Pro
                325                 330                 335     
Ala Gly Tyr Met Gly Gly Met Gln Ala Ser Met Met Gly Val Pro Asn
            340                 345                 350         
Gly Met Met Thr Thr Gln Gln Ala Gly Tyr Met Ala Gly Met Ala Ala
        355                 360                 365             
Met Pro Gln Thr Val Tyr Gly Val Gln Pro Ala Gln Gln Leu Gln Trp
    370                 375                 380                 
Asn Leu Thr Gln Met Thr Gln Gln Met Ala Gly Met Asn Phe Tyr Gly
385                 390                 395                 400 
Ala Asn Gly Met Met Asn Tyr Gly Gln Ser Met Ser Gly Gly Asn Gly
                405                 410                 415     
Gln Ala Ala Asn Gln Thr Leu Ser Pro Gln Met Trp Lys
            420                 425                 


<210> 5778
<211> 750
<212> PRT
<213> Homo sapiens

<400> 5778
Met Ser Ser Lys Arg Pro Ala Ser Pro Tyr Gly Glu Ala Asp Gly Glu
 1               5                  10                  15      
Val Ala Met Val Thr Ser Arg Gln Lys Val Glu Glu Glu Glu Ser Asp
            20                  25                  30          
Gly Leu Pro Ala Phe His Leu Pro Leu His Val Ser Phe Pro Asn Lys
        35                  40                  45              
Pro His Ser Glu Glu Phe Gln Pro Val Ser Leu Leu Thr Gln Glu Thr
    50                  55                  60                  
Cys Gly His Arg Thr Pro Thr Ser Gln His Asn Thr Met Glu Val Asp
65                  70                  75                  80  
Gly Asn Lys Val Met Ser Ser Phe Ala Pro His Asn Ser Ser Thr Ser
                85                  90                  95      
Pro Gln Lys Ala Glu Glu Gly Gly Arg Gln Ser Gly Glu Ser Leu Ser
            100                 105                 110         
Ser Thr Ala Leu Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala Asp
        115                 120                 125             
Val Val Asp Thr Leu Lys Gln Arg Lys Met Glu Glu Leu Ile Lys Asn
    130                 135                 140                 
Glu Pro Glu Glu Thr Pro Ser Ile Glu Lys Leu Leu Ser Lys Asp Trp
145                 150                 155                 160 
Lys Asp Lys Leu Leu Ala Met Gly Ser Gly Asn Phe Gly Glu Ile Lys
                165                 170                 175     
Gly Thr Pro Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Met Gly Met
            180                 185                 190         
Ile Asn Gln Leu Thr Ser Leu Arg Glu Gln Leu Leu Ala Ala His Asp
        195                 200                 205             
Glu Gln Lys Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg Gln Gln
    210                 215                 220                 
Met Glu Leu Ala Lys Gln Gln Gln Glu Gln Ile Ala Arg Gln Gln Gln
225                 230                 235                 240 
Gln Leu Leu Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln Gln Ile
                245                 250                 255     
Gln Val Gln Gly Gln Leu Pro Pro Leu Met Ile Pro Val Phe Pro Pro
            260                 265                 270         
Asp Gln Arg Thr Leu Ala Ala Ala Ala Gln Gln Gly Phe Leu Leu Pro
        275                 280                 285             
Pro Gly Phe Ser Tyr Lys Ala Gly Cys Ser Asp Pro Tyr Pro Val Gln
    290                 295                 300                 
Leu Ile Pro Thr Thr Met Ala Ala Ala Ala Ala Ala Thr Pro Gly Leu
305                 310                 315                 320 
Gly Pro Leu Gln Leu Gln Gln Leu Tyr Ala Ala Gln Leu Ala Ala Met
                325                 330                 335     
Gln Val Ser Pro Gly Gly Lys Leu Pro Gly Ile Pro Gln Gly Asn Leu
            340                 345                 350         
Gly Ala Ala Val Ser Pro Thr Ser Ile His Thr Asp Lys Ser Thr Asn
        355                 360                 365             
Ser Pro Pro Pro Lys Ser Lys Asp Glu Val Ala Gln Pro Leu Asn Leu
    370                 375                 380                 
Ser Ala Lys Pro Lys Thr Ser Asp Gly Lys Ser Pro Thr Ser Pro Thr
385                 390                 395                 400 
Ser Pro His Met Pro Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu
                405                 410                 415     
Lys Ala Ser Val Pro Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser
            420                 425                 430         
Thr Ile Gly Tyr Leu Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln
        435                 440                 445             
Glu Ala Arg Gln Met Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu
    450                 455                 460                 
Asp Gly Lys Val Ala Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg
465                 470                 475                 480 
Thr Glu Lys Glu Lys Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala
                485                 490                 495     
Val Lys Gln Asn Glu Glu Gly Lys Phe Ser His Ala Met Met Asp Phe
            500                 505                 510         
Asn Leu Ser Gly Asp Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg
        515                 520                 525             
Ile Tyr Arg Glu Ser Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys
    530                 535                 540                 
Arg Pro Met Asn Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys
545                 550                 555                 560 
Ile Leu Gln Ala Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile
                565                 570                 575     
Leu Gly Ser Arg Trp Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr
            580                 585                 590         
Tyr Glu Glu Gln Ala Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro
        595                 600                 605             
Asp Tyr Lys Tyr Lys Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly
    610                 615                 620                 
Lys Lys Leu Arg Ile Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg
625                 630                 635                 640 
Gln Glu Met Arg Gln Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro
                645                 650                 655     
Ile Ala Thr Ala Gly Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly
            660                 665                 670         
Met Pro Ser Pro His Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser
        675                 680                 685             
Pro Glu Pro Gly Met Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly
    690                 695                 700                 
Glu Glu Pro His Ile Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly
705                 710                 715                 720 
Glu Ile Tyr Asp Glu Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp
                725                 730                 735     
Tyr Gly Ser Asp Ser Glu Asn His Ile Ala Gly Gln Ala Asn
            740                 745                 750 


<210> 5779
<211> 763
<212> PRT
<213> Homo sapiens

<400> 5779
Met Leu Thr Asp Pro Asp Leu Pro Gln Glu Phe Glu Arg Met Ser Ser
 1               5                  10                  15      
Lys Arg Pro Ala Ser Pro Tyr Gly Glu Ala Asp Gly Glu Val Ala Met
            20                  25                  30          
Val Thr Ser Arg Gln Lys Val Glu Glu Glu Glu Ser Asp Gly Leu Pro
        35                  40                  45              
Ala Phe His Leu Pro Leu His Val Ser Phe Pro Asn Lys Pro His Ser
    50                  55                  60                  
Glu Glu Phe Gln Pro Val Ser Leu Leu Thr Gln Glu Thr Cys Gly His
65                  70                  75                  80  
Arg Thr Pro Thr Ser Gln His Asn Thr Met Glu Val Asp Gly Asn Lys
                85                  90                  95      
Val Met Ser Ser Phe Ala Pro His Asn Ser Ser Thr Ser Pro Gln Lys
            100                 105                 110         
Ala Glu Glu Gly Gly Arg Gln Ser Gly Glu Ser Leu Ser Ser Thr Ala
        115                 120                 125             
Leu Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala Asp Val Val Asp
    130                 135                 140                 
Thr Leu Lys Gln Arg Lys Met Glu Glu Leu Ile Lys Asn Glu Pro Glu
145                 150                 155                 160 
Glu Thr Pro Ser Ile Glu Lys Leu Leu Ser Lys Asp Trp Lys Asp Lys
                165                 170                 175     
Leu Leu Ala Met Gly Ser Gly Asn Phe Gly Glu Ile Lys Gly Thr Pro
            180                 185                 190         
Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Met Gly Met Ile Asn Gln
        195                 200                 205             
Leu Thr Ser Leu Arg Glu Gln Leu Leu Ala Ala His Asp Glu Gln Lys
    210                 215                 220                 
Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg Gln Gln Met Glu Leu
225                 230                 235                 240 
Ala Lys Gln Gln Gln Glu Gln Ile Ala Arg Gln Gln Gln Gln Leu Leu
                245                 250                 255     
Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln Gln Ile Gln Val Gln
            260                 265                 270         
Gly Gln Leu Pro Pro Leu Met Ile Pro Val Phe Pro Pro Asp Gln Arg
        275                 280                 285             
Thr Leu Ala Ala Ala Ala Gln Gln Gly Phe Leu Leu Pro Pro Gly Phe
    290                 295                 300                 
Ser Tyr Lys Ala Gly Cys Ser Asp Pro Tyr Pro Val Gln Leu Ile Pro
305                 310                 315                 320 
Thr Thr Met Ala Ala Ala Ala Ala Ala Thr Pro Gly Leu Gly Pro Leu
                325                 330                 335     
Gln Leu Gln Gln Leu Tyr Ala Ala Gln Leu Ala Ala Met Gln Val Ser
            340                 345                 350         
Pro Gly Gly Lys Leu Pro Gly Ile Pro Gln Gly Asn Leu Gly Ala Ala
        355                 360                 365             
Val Ser Pro Thr Ser Ile His Thr Asp Lys Ser Thr Asn Ser Pro Pro
    370                 375                 380                 
Pro Lys Ser Lys Asp Glu Val Ala Gln Pro Leu Asn Leu Ser Ala Lys
385                 390                 395                 400 
Pro Lys Thr Ser Asp Gly Lys Ser Pro Thr Ser Pro Thr Ser Pro His
                405                 410                 415     
Met Pro Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu Lys Ala Ser
            420                 425                 430         
Val Pro Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser Thr Ile Gly
        435                 440                 445             
Tyr Leu Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln Glu Ala Arg
    450                 455                 460                 
Gln Met Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu Asp Gly Lys
465                 470                 475                 480 
Val Ala Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg Thr Glu Lys
                485                 490                 495     
Glu Lys Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln
            500                 505                 510         
Asn Glu Glu Gly Lys Phe Ser His Ala Met Met Asp Phe Asn Leu Ser
        515                 520                 525             
Gly Asp Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg
    530                 535                 540                 
Glu Ser Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met
545                 550                 555                 560 
Asn Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln
                565                 570                 575     
Ala Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser
            580                 585                 590         
Arg Trp Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu
        595                 600                 605             
Gln Ala Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys
    610                 615                 620                 
Tyr Lys Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu
625                 630                 635                 640 
Arg Ile Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met
                645                 650                 655     
Arg Gln Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr
            660                 665                 670         
Ala Gly Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly Met Pro Ser
        675                 680                 685             
Pro His Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro
    690                 695                 700                 
Gly Met Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly Glu Glu Pro
705                 710                 715                 720 
His Ile Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr
                725                 730                 735     
Asp Glu Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp Tyr Gly Ser
            740                 745                 750         
Asp Ser Glu Asn His Ile Ala Gly Gln Ala Asn
        755                 760             


<210> 5780
<211> 377
<212> PRT
<213> Homo sapiens

<400> 5780
Met His Asp Glu Val Ala Gln Pro Leu Asn Leu Ser Ala Lys Pro Lys
 1               5                  10                  15      
Thr Ser Asp Gly Lys Ser Pro Thr Ser Pro Thr Ser Pro His Met Pro
            20                  25                  30          
Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu Lys Ala Ser Val Pro
        35                  40                  45              
Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser Thr Ile Gly Tyr Leu
    50                  55                  60                  
Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln Glu Ala Arg Gln Met
65                  70                  75                  80  
Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu Asp Gly Lys Val Ala
                85                  90                  95      
Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg Thr Glu Lys Glu Lys
            100                 105                 110         
Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln Asn Glu
        115                 120                 125             
Glu Gly Lys Phe Ser His Ala Met Met Asp Phe Asn Leu Ser Gly Asp
    130                 135                 140                 
Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg Glu Ser
145                 150                 155                 160 
Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met Asn Ala
                165                 170                 175     
Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln Ala Phe
            180                 185                 190         
Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser Arg Trp
        195                 200                 205             
Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu Gln Ala
    210                 215                 220                 
Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys Tyr Lys
225                 230                 235                 240 
Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu Arg Ile
                245                 250                 255     
Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met Arg Gln
            260                 265                 270         
Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr Ala Gly
        275                 280                 285             
Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly Met Pro Ser Pro His
    290                 295                 300                 
Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro Gly Met
305                 310                 315                 320 
Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly Glu Glu Pro His Ile
                325                 330                 335     
Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr Asp Glu
            340                 345                 350         
Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp Tyr Gly Ser Asp Ser
        355                 360                 365             
Glu Asn His Ile Ala Gly Gln Ala Asn
    370                 375         


<210> 5781
<211> 347
<212> PRT
<213> Homo sapiens

<400> 5781
Met Pro Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu Lys Ala Ser
 1               5                  10                  15      
Val Pro Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser Thr Ile Gly
            20                  25                  30          
Tyr Leu Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln Glu Ala Arg
        35                  40                  45              
Gln Met Lys Glu Gln Leu Arg Arg Glu Gln Gln Val Leu Asp Gly Lys
    50                  55                  60                  
Val Ala Val Val Asn Ser Leu Gly Leu Asn Asn Cys Arg Thr Glu Lys
65                  70                  75                  80  
Glu Lys Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln
                85                  90                  95      
Asn Glu Glu Gly Lys Phe Ser His Ala Met Met Asp Phe Asn Leu Ser
            100                 105                 110         
Gly Asp Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg
        115                 120                 125             
Glu Ser Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met
    130                 135                 140                 
Asn Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln
145                 150                 155                 160 
Ala Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser
                165                 170                 175     
Arg Trp Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu
            180                 185                 190         
Gln Ala Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys
        195                 200                 205             
Tyr Lys Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu
    210                 215                 220                 
Arg Ile Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met
225                 230                 235                 240 
Arg Gln Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr
                245                 250                 255     
Ala Gly Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly Met Pro Ser
            260                 265                 270         
Pro His Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro
        275                 280                 285             
Gly Met Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly Glu Glu Pro
    290                 295                 300                 
His Ile Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr
305                 310                 315                 320 
Asp Glu Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp Tyr Gly Ser
                325                 330                 335     
Asp Ser Glu Asn His Ile Ala Gly Gln Ala Asn
            340                 345         


<210> 5782
<211> 211
<212> PRT
<213> Homo sapiens

<400> 5782
Met Gln Ser Ala Met Phe Leu Ala Val Gln His Asp Cys Arg Pro Met
 1               5                  10                  15      
Asp Lys Ser Ala Gly Ser Gly His Lys Ser Glu Glu Lys Arg Glu Lys
            20                  25                  30          
Met Lys Arg Thr Leu Leu Lys Asp Trp Lys Thr Arg Leu Ser Tyr Phe
        35                  40                  45              
Leu Gln Asn Ser Ser Thr Pro Gly Lys Pro Lys Thr Gly Lys Lys Ser
    50                  55                  60                  
Lys Gln Gln Ala Phe Ile Lys Pro Ser Pro Glu Glu Ala Gln Leu Trp
65                  70                  75                  80  
Ser Glu Ala Phe Asp Glu Leu Leu Ala Ser Lys Tyr Gly Leu Ala Ala
                85                  90                  95      
Phe Arg Ala Phe Leu Lys Ser Glu Phe Cys Glu Glu Asn Ile Glu Phe
            100                 105                 110         
Trp Leu Ala Cys Glu Asp Phe Lys Lys Thr Lys Ser Pro Gln Lys Leu
        115                 120                 125             
Ser Ser Lys Ala Arg Lys Ile Tyr Thr Asp Phe Ile Glu Lys Glu Ala
    130                 135                 140                 
Pro Lys Glu Ile Asn Ile Asp Phe Gln Thr Lys Thr Leu Ile Ala Gln
145                 150                 155                 160 
Asn Ile Gln Glu Ala Thr Ser Gly Cys Phe Thr Thr Ala Gln Lys Arg
                165                 170                 175     
Val Tyr Ser Leu Met Glu Asn Asn Ser Tyr Pro Arg Phe Leu Glu Ser
            180                 185                 190         
Glu Phe Tyr Gln Asp Leu Cys Lys Lys Pro Gln Ile Thr Thr Glu Pro
        195                 200                 205             
His Ala Thr
    210     


<210> 5783
<211> 1345
<212> PRT
<213> Homo sapiens

<400> 5783
Leu Thr Arg Arg Leu Pro Pro Ile Lys Glu Ala Lys Pro Arg Leu Gln
 1               5                  10                  15      
Lys Leu Phe Arg Asp Phe Trp Leu Tyr Ser Val Leu Met Gly Phe Ala
            20                  25                  30          
Val Glu Gly Ser Gly Leu Trp Pro Glu Glu Trp Tyr Glu Gly Val Cys
        35                  40                  45              
Glu Ile Ala Thr Lys Ser Pro Leu Leu Thr Phe Pro Ser Lys Glu Pro
    50                  55                  60                  
Leu Arg Ser Val Leu Gln Tyr Asn Ser Ala Met Lys Asn Asp Thr Val
65                  70                  75                  80  
Thr Pro Ala Glu Leu Ser Glu Leu Arg Ser Thr Ile Ile Asn Leu Leu
                85                  90                  95      
Asp Pro Pro Pro Glu Val Ser Ala Leu Ile Asn Lys Leu Asp Phe Ala
            100                 105                 110         
Met Ser Thr Tyr Leu Leu Ser Val Tyr Arg Leu Glu Tyr Met Arg Val
        115                 120                 125             
Leu Arg Ser Thr Asp Pro Asp Arg Phe Gln Val Met Phe Cys Tyr Phe
    130                 135                 140                 
Glu Asp Lys Ala Ile Gln Lys Asp Lys Ser Gly Met Met Gln Cys Val
145                 150                 155                 160 
Ile Ala Val Ala Asp Lys Val Phe Asp Ala Phe Leu Asn Met Met Ala
                165                 170                 175     
Asp Lys Ala Lys Thr Lys Glu Asn Glu Glu Glu Leu Glu Arg His Ala
            180                 185                 190         
Gln Phe Leu Leu Val Asn Phe Asn His Ile His Lys Arg Ile Arg Arg
        195                 200                 205             
Val Ala Asp Lys Tyr Leu Ser Gly Leu Val Asp Lys Phe Pro His Leu
    210                 215                 220                 
Leu Trp Ser Gly Thr Val Leu Lys Thr Met Leu Asp Ile Leu Gln Thr
225                 230                 235                 240 
Leu Ser Leu Ser Leu Ser Ala Asp Ile His Lys Asp Gln Pro Tyr Tyr
                245                 250                 255     
Asp Ile Pro Asp Ala Pro Tyr Arg Ile Thr Val Pro Asp Thr Tyr Glu
            260                 265                 270         
Ala Arg Glu Ser Ile Val Lys Asp Phe Ala Ala Arg Cys Gly Met Ile
        275                 280                 285             
Leu Gln Glu Ala Met Lys Trp Ala Pro Thr Val Thr Lys Ser His Leu
    290                 295                 300                 
Gln Glu Tyr Leu Asn Lys His Gln Asn Trp Val Ser Gly Leu Ser Gln
305                 310                 315                 320 
His Thr Gly Leu Ala Met Ala Thr Glu Ser Ile Leu His Phe Ala Gly
                325                 330                 335     
Tyr Asn Lys Gln Asn Thr Thr Leu Gly Leu Ser Glu Arg Pro Ala Cys
            340                 345                 350         
Val Lys Lys Asp Tyr Ser Asn Phe Met Ala Ser Leu Asn Leu Arg Asn
        355                 360                 365             
Arg Tyr Ala Gly Glu Val Leu Leu Leu Gly Val Ser Leu Met Ser Gly
    370                 375                 380                 
Lys Ser Ile Lys Gly His His Trp Pro Gln Leu Val Asn Ser Cys Trp
385                 390                 395                 400 
Pro Arg Glu Ala Val Leu Gly Phe Ser Cys Cys Trp Arg Pro Leu Thr
                405                 410                 415     
Asp Val Cys Leu Val Pro Asp Cys Asp Pro Gln Leu Leu His His Leu
            420                 425                 430         
Cys Trp Gly Pro Leu Arg Met Phe Asn Glu His Gly Met Glu Thr Ala
        435                 440                 445             
Leu Ala Cys Trp Glu Trp Leu Leu Ala Gly Lys Asp Gly Val Glu Val
    450                 455                 460                 
Pro Phe Met Arg Glu Met Ala Gly Ala Trp His Met Thr Val Glu Gln
465                 470                 475                 480 
Lys Phe Gly Leu Phe Ser Ala Glu Ile Lys Glu Ala Asp Pro Leu Ala
                485                 490                 495     
Ala Ser Glu Ala Ser Gln Pro Lys Pro Cys Pro Pro Glu Val Thr Pro
            500                 505                 510         
His Tyr Ile Trp Ile Asp Phe Leu Val Gln Arg Phe Glu Ile Ala Lys
        515                 520                 525             
Tyr Cys Ser Ser Asp Gln Val Glu Ile Phe Ser Ser Leu Leu Gln Arg
    530                 535                 540                 
Ser Met Ser Leu Asn Ile Gly Gly Ala Lys Gly Ser Met Asn Arg His
545                 550                 555                 560 
Val Ala Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr Leu Gly Leu Ser
                565                 570                 575     
Leu Leu His Ala Asp Val Val Pro Asn Ala Thr Ile Arg Asn Val Leu
            580                 585                 590         
Arg Glu Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe Ser Cys Pro Pro
        595                 600                 605             
Lys Phe Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu Asp Ile Ser Ile
    610                 615                 620                 
Met Ile Lys Phe Trp Thr Ala Met Phe Ser Asp Lys Lys Tyr Leu Thr
625                 630                 635                 640 
Ala Ser Gln Leu Val Pro Pro Gly Arg Trp Glu Val Cys Cys Trp Gly
                645                 650                 655     
His His Met Gln Ala Ile Ile Leu Val Ala Ser Cys Leu Met Asp Thr
            660                 665                 670         
Cys Ser Asp Ser Arg Thr Glu His Cys Lys Leu Pro Leu Gly Leu Glu
        675                 680                 685             
Ser Gln Gly Arg Gln Val Ala Ser Glu Asp Tyr Thr Cys Ala Leu Ser
    690                 695                 700                 
Phe Leu Leu Gly Met Ser Lys Lys Thr Asn Arg Gly Ser Gln Leu His
705                 710                 715                 720 
Lys Tyr Tyr Met Lys Arg Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr
                725                 730                 735     
Glu Ile Glu Arg Leu Ile Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu
            740                 745                 750         
Leu Glu Leu Asp Gln Ala Gly Glu Asn Ser Val Ala Asn Trp Arg Ser
        755                 760                 765             
Lys Tyr Ile Ser Leu Ser Glu Lys Gln Trp Lys Asp Asn Val Asn Leu
    770                 775                 780                 
Ala Trp Ser Ile Ser Pro Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe
785                 790                 795                 800 
Lys Asn Thr Glu Ala Ile Gly Asn Glu Val Thr Arg Leu Val Arg Leu
                805                 810                 815     
Asp Pro Gly Ala Val Ser Asp Val Pro Glu Ala Ile Lys Phe Leu Val
            820                 825                 830         
Thr Trp His Thr Ile Asp Ala Asp Ala Pro Glu Leu Ser His Val Leu
        835                 840                 845             
Cys Trp Ala Pro Thr Asp Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser
    850                 855                 860                 
Met Tyr Pro Pro His Pro Leu Thr Ala Gln Tyr Gly Val Lys Val Leu
865                 870                 875                 880 
Arg Ser Phe Pro Pro Asp Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val
                885                 890                 895     
Gln Ala Leu Arg Tyr Asp Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu
            900                 905                 910         
Trp Ala Ala Ser Lys Ser Gln Leu Leu Ala His Gln Phe Ile Trp Asn
        915                 920                 925             
Met Lys Thr Asn Ile Tyr Leu Asp Glu Glu Gly His Gln Lys Asp Pro
    930                 935                 940                 
Asp Ile Gly Asp Leu Leu Asp Gln Leu Val Glu Glu Ile Thr Gly Ser
945                 950                 955                 960 
Leu Ser Gly Pro Ala Lys Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe
                965                 970                 975     
Asn Lys Ile Thr Asn Val Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly
            980                 985                 990         
Asp Glu Arg Lys Lys Ala Cys Leu Ser Ala Leu Ser Glu Val Lys Val
        995                 1000                1005            
Gln Pro Gly Cys Tyr Leu Pro Ser Asn Pro Glu Ala Ile Val Leu Asp
    1010                1015                1020                
Ile Asp Tyr Lys Ser Gly Thr Pro Met Gln Ser Ala Ala Lys Ala Pro
1025                1030                1035                1040
Tyr Leu Ala Lys Phe Lys Val Lys Arg Cys Gly Val Ser Glu Leu Glu
                1045                1050                1055    
Lys Glu Gly Leu Arg Cys Arg Ser Asp Ser Glu Asp Glu Cys Ser Thr
            1060                1065                1070        
Gln Glu Ala Asp Gly Gln Lys Ile Ser Trp Gln Ala Ala Ile Phe Lys
        1075                1080                1085            
Val Gly Asp Asp Cys Arg Gln Asp Met Leu Ala Leu Gln Ile Ile Asp
    1090                1095                1100                
Leu Phe Lys Asn Ile Phe Gln Leu Val Gly Leu Asp Leu Phe Val Phe
1105                1110                1115                1120
Pro Tyr Arg Val Val Ala Thr Ala Pro Gly Cys Gly Val Ile Glu Cys
                1125                1130                1135    
Ile Pro Asp Cys Thr Ser Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe
            1140                1145                1150        
Gly Met Tyr Asp Tyr Phe Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu
        1155                1160                1165            
Ala Phe Gln Gln Ala Arg Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr
    1170                1175                1180                
Ser Leu Leu Leu Phe Leu Leu Gln Ile Lys Asp Arg His Asn Gly Asn
1185                1190                1195                1200
Ile Met Leu Asp Lys Lys Gly His Ile Ile His Ile Asp Phe Gly Phe
                1205                1210                1215    
Met Phe Glu Ser Ser Pro Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile
            1220                1225                1230        
Lys Leu Thr Asp Glu Met Val Met Ile Met Gly Gly Lys Met Glu Ala
        1235                1240                1245            
Thr Pro Phe Lys Trp Phe Met Glu Met Cys Val Arg Gly Tyr Leu Ala
    1250                1255                1260                
Val Arg Pro Tyr Met Asp Ala Val Val Ser Leu Val Thr Leu Met Leu
1265                1270                1275                1280
Asp Thr Gly Leu Pro Cys Phe Arg Gly Gln Thr Ile Lys Leu Leu Asn
                1285                1290                1295    
His Lys Gly Leu Ile Gly Gln Val Gly Leu Pro Val Gly Arg Asp Pro
            1300                1305                1310        
Arg Pro Cys Trp Leu Leu Glu Ser Pro Phe Thr Leu Pro Trp Pro Phe
        1315                1320                1325            
Arg Ser Arg Thr Tyr Asp Met Ile Gln Tyr Tyr Gln Asn Asp Ile Pro
    1330                1335                1340                
Tyr
1345


<210> 5784
<211> 623
<212> PRT
<213> Homo sapiens

<400> 5784
Met Ser Cys Arg Gln Phe Ser Ser Ser Tyr Leu Ser Arg Ser Gly Gly
 1               5                  10                  15      
Gly Gly Gly Gly Gly Leu Gly Ser Gly Gly Ser Ile Arg Ser Ser Tyr
            20                  25                  30          
Ser Arg Phe Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Arg Phe Ser
        35                  40                  45              
Ser Ser Ser Gly Tyr Gly Gly Gly Ser Ser Arg Val Cys Gly Arg Gly
    50                  55                  60                  
Gly Gly Gly Ser Phe Gly Tyr Ser Tyr Gly Gly Gly Ser Gly Gly Gly
65                  70                  75                  80  
Phe Ser Ala Ser Ser Leu Gly Gly Gly Phe Gly Gly Gly Ser Arg Gly
                85                  90                  95      
Phe Gly Gly Ala Ser Gly Gly Gly Tyr Ser Ser Ser Gly Gly Phe Gly
            100                 105                 110         
Gly Gly Phe Gly Gly Gly Ser Gly Gly Gly Phe Gly Gly Gly Tyr Gly
        115                 120                 125             
Ser Gly Phe Gly Gly Phe Gly Gly Phe Gly Gly Gly Ala Gly Gly Gly
    130                 135                 140                 
Asp Gly Gly Ile Leu Thr Ala Asn Glu Lys Ser Thr Met Gln Glu Leu
145                 150                 155                 160 
Asn Ser Arg Leu Ala Ser Tyr Leu Asp Lys Val Gln Ala Leu Glu Glu
                165                 170                 175     
Ala Asn Asn Asp Leu Glu Asn Lys Ile Gln Asp Trp Tyr Asp Lys Lys
            180                 185                 190         
Gly Pro Ala Ala Ile Gln Lys Asn Tyr Ser Pro Tyr Tyr Asn Thr Ile
        195                 200                 205             
Asp Asp Leu Lys Asp Gln Ile Val Asp Leu Thr Val Gly Asn Asn Lys
    210                 215                 220                 
Thr Leu Leu Asp Ile Asp Asn Thr Arg Met Thr Leu Asp Asp Phe Arg
225                 230                 235                 240 
Ile Lys Phe Glu Met Glu Gln Asn Leu Arg Gln Gly Val Asp Ala Asp
                245                 250                 255     
Ile Asn Gly Leu Arg Gln Val Leu Asp Asn Leu Thr Met Glu Lys Ser
            260                 265                 270         
Asp Leu Glu Met Gln Tyr Glu Thr Leu Gln Glu Glu Leu Met Ala Leu
        275                 280                 285             
Lys Lys Asn His Lys Glu Glu Met Ser Gln Leu Thr Gly Gln Asn Ser
    290                 295                 300                 
Gly Asp Val Asn Val Glu Ile Asn Val Ala Pro Gly Lys Asp Leu Thr
305                 310                 315                 320 
Lys Thr Leu Asn Asp Met Arg Gln Glu Tyr Glu Gln Leu Ile Ala Lys
                325                 330                 335     
Asn Arg Lys Asp Ile Glu Asn Gln Tyr Glu Thr Gln Ile Thr Gln Ile
            340                 345                 350         
Glu His Glu Val Ser Ser Ser Gly Gln Glu Val Gln Ser Ser Ala Lys
        355                 360                 365             
Glu Val Thr Gln Leu Arg His Gly Val Gln Glu Leu Glu Ile Glu Leu
    370                 375                 380                 
Gln Ser Gln Leu Ser Lys Lys Ala Ala Leu Glu Lys Ser Leu Glu Asp
385                 390                 395                 400 
Thr Lys Asn Arg Tyr Cys Gly Gln Leu Gln Met Ile Gln Glu Gln Ile
                405                 410                 415     
Ser Asn Leu Glu Ala Gln Ile Thr Asp Val Arg Gln Glu Ile Glu Cys
            420                 425                 430         
Gln Asn Gln Glu Tyr Ser Leu Leu Leu Ser Ile Lys Met Arg Leu Glu
        435                 440                 445             
Lys Glu Ile Glu Thr Tyr His Asn Leu Leu Glu Gly Gly Gln Glu Asp
    450                 455                 460                 
Phe Glu Ser Ser Gly Ala Gly Lys Ile Gly Leu Gly Gly Arg Gly Gly
465                 470                 475                 480 
Ser Gly Gly Ser Tyr Gly Arg Gly Ser Arg Gly Gly Ser Gly Gly Ser
                485                 490                 495     
Tyr Gly Gly Gly Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Ser
            500                 505                 510         
Arg Gly Gly Ser Gly Gly Ser Tyr Gly Gly Gly Ser Gly Ser Gly Gly
        515                 520                 525             
Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Gly Gly His Ser Gly
    530                 535                 540                 
Gly Ser Gly Gly Gly His Ser Gly Gly Ser Gly Gly Asn Tyr Gly Gly
545                 550                 555                 560 
Gly Ser Gly Ser Gly Gly Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser
                565                 570                 575     
Gly Ser Arg Gly Gly Ser Gly Gly Ser His Gly Gly Gly Ser Gly Phe
            580                 585                 590         
Gly Gly Glu Ser Gly Gly Ser Tyr Gly Gly Gly Glu Glu Ala Ser Gly
        595                 600                 605             
Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Lys Ser Ser His Ser
    610                 615                 620             


<210> 5785
<211> 1243
<212> PRT
<213> Homo sapiens

<400> 5785
Met Glu Asn Cys Ser Ala Ala Ser Thr Phe Leu Thr Asp Ser Leu Glu
 1               5                  10                  15      
Leu Glu Leu Gly Thr Glu Trp Cys Lys Pro Pro Tyr Phe Ser Cys Ala
            20                  25                  30          
Val Asp Asn Arg Gly Gly Gly Lys His Phe Ser Gly Glu Ser Tyr Leu
        35                  40                  45              
Cys Ser Gly Ala Leu Lys Arg Leu Ile Leu Asn Leu Asp Pro Leu Pro
    50                  55                  60                  
Thr Asn Phe Glu Glu Asp Thr Leu Glu Ile Phe Gly Ile Gln Trp Val
65                  70                  75                  80  
Thr Glu Thr Ala Leu Val Asn Ser Ser Arg Glu Leu Phe His Leu Phe
                85                  90                  95      
Arg Gln Gln Leu Tyr Asn Leu Glu Thr Leu Leu Gln Ser Ser Cys Asp
            100                 105                 110         
Phe Gly Lys Val Ser Thr Leu His Cys Lys Ala Asp Asn Ile Arg Gln
        115                 120                 125             
Gln Cys Val Leu Phe Leu His Tyr Val Lys Val Phe Ile Phe Arg Tyr
    130                 135                 140                 
Leu Lys Val Gln Asn Ala Glu Ser His Val Pro Val His Pro Tyr Glu
145                 150                 155                 160 
Ala Leu Glu Ala Gln Leu Pro Ser Val Leu Ile Asp Glu Leu His Gly
                165                 170                 175     
Leu Leu Leu Tyr Ile Gly His Leu Ser Glu Leu Pro Ser Val Asn Ile
            180                 185                 190         
Gly Ala Phe Val Asn Gln Asn Gln Ile Lys Leu Phe Pro Pro Ser Trp
        195                 200                 205             
His Leu Leu His Leu His Leu Asp Ile His Trp Leu Val Leu Glu Ile
    210                 215                 220                 
Leu Tyr Met Leu Gly Glu Lys Leu Lys Gln Val Val Tyr Gly His Gln
225                 230                 235                 240 
Phe Met Asn Leu Ala Ser Asp Asn Leu Thr Asn Ile Ser Leu Phe Glu
                245                 250                 255     
Glu His Cys Glu Thr Leu Leu Cys Asp Leu Ile Ser Leu Ser Leu Asn
            260                 265                 270         
Arg Tyr Asp Lys Val Arg Ser Ser Glu Ser Leu Met Ser Asp Gln Cys
        275                 280                 285             
Pro Cys Leu Arg Ile Lys Glu Leu Trp Val Leu Leu Ile His Leu Leu
    290                 295                 300                 
Asp His Arg Ser Lys Trp Phe Val Ser Glu Ser Phe Trp Asn Trp Leu
305                 310                 315                 320 
Asn Lys Leu Leu Lys Thr Leu Leu Glu Lys Ser Ser Asp Arg Arg Arg
                325                 330                 335     
Ser Ser Met Pro Val Ile Gln Ser Arg Asp Pro Leu Gly Phe Ser Trp
            340                 345                 350         
Trp Ile Ile Thr His Val Ala Ser Phe Tyr Lys Phe Asp Arg His Gly
        355                 360                 365             
Val Pro Asp Glu Met Arg Lys Val Glu Ser Asn Trp Asn Phe Val Glu
    370                 375                 380                 
Glu Leu Leu Lys Lys Ser Ile Ser Val Gln Gly Val Ile Leu Glu Glu
385                 390                 395                 400 
Gln Leu Arg Met Tyr Leu His Cys Cys Leu Thr Leu Cys Asp Phe Trp
                405                 410                 415     
Glu Pro Asn Ile Ala Ile Val Thr Ile Leu Trp Glu Tyr Tyr Ser Lys
            420                 425                 430         
Asn Leu Asn Ser Ser Phe Ser Ile Ser Trp Leu Pro Phe Lys Gly Leu
        435                 440                 445             
Ala Asn Thr Met Lys Ser Pro Leu Ser Met Leu Glu Met Val Lys Thr
    450                 455                 460                 
Cys Cys Cys Asp Lys Gln Asp Gln Glu Leu Tyr Lys Ser Ser Ser Ser
465                 470                 475                 480 
Tyr Thr Ile Phe Leu Cys Ile Leu Ala Lys Val Val Lys Lys Ala Met
                485                 490                 495     
Lys Ser Asn Gly Pro His Pro Trp Lys Gln Val Lys Gly Arg Ile Tyr
            500                 505                 510         
Ser Lys Phe His Gln Lys Arg Met Glu Glu Leu Thr Glu Val Gly Leu
        515                 520                 525             
Gln Asn Phe Phe Ser Leu Phe Leu Leu Leu Ala Ala Val Ala Glu Val
    530                 535                 540                 
Glu Asp Val Ala Ser His Val Leu Asp Leu Leu Asn Phe Leu Lys Pro
545                 550                 555                 560 
Ala Phe Val Met Ser Gln Arg Ala Leu Ile Trp Lys Gly His Met Ala
                565                 570                 575     
Phe Leu Leu Met Tyr Ala Gln Lys Asn Leu Asp Ile Gly Val Leu Ala
            580                 585                 590         
Glu Lys Phe Ser Cys Ala Phe Arg Glu Lys Ala Lys Glu Phe Leu Val
        595                 600                 605             
Ser Lys Asn Glu Glu Met Val Gln Arg Gln Thr Ile Trp Thr Leu Leu
    610                 615                 620                 
Ser Ile Tyr Ile Asp Gly Val Gln Glu Val Phe Glu Thr Ser Tyr Cys
625                 630                 635                 640 
Leu Tyr Pro Ser His Glu Lys Leu Leu Asn Asp Gly Phe Ser Met Leu
                645                 650                 655     
Leu Arg Ala Cys Arg Glu Ser Glu Leu Arg Thr Val Leu Ser Phe Leu
            660                 665                 670         
Gln Ala Val Leu Ala Arg Ile Arg Ser Met His Gln Gln Leu Cys Gln
        675                 680                 685             
Glu Leu Gln Arg Asp Asn Val Asp Leu Phe Val Gln Ser Ser Leu Ser
    690                 695                 700                 
Ala Lys Glu Arg His Leu Ala Ala Val Ala Ser Ala Leu Trp Arg His
705                 710                 715                 720 
Phe Phe Ser Phe Leu Lys Ser Gln Arg Met Ser Gln Val Val Pro Phe
                725                 730                 735     
Ser Gln Leu Ala Asp Ala Ala Ala Asp Phe Thr Leu Leu Ala Met Asp
            740                 745                 750         
Met Pro Ser Thr Ala Pro Ser Asp Phe Gln Pro Gln Pro Val Ile Ser
        755                 760                 765             
Ile Ile Gln Leu Phe Gly Trp Asp Asp Ile Ile Cys Pro Gln Val Val
    770                 775                 780                 
Ala Arg Tyr Leu Ser His Val Leu Gln Asn Ser Thr Leu Cys Glu Ala
785                 790                 795                 800 
Leu Ser His Ser Gly Tyr Val Ser Phe Gln Ala Leu Thr Val Arg Ser
                805                 810                 815     
Trp Ile Arg Cys Val Leu Gln Met Tyr Ile Lys Asn Leu Ser Gly Pro
            820                 825                 830         
Asp Asp Leu Leu Ile Asp Lys Asn Leu Glu Glu Ala Val Glu Lys Glu
        835                 840                 845             
Tyr Met Lys Gln Leu Val Lys Leu Thr Arg Leu Leu Phe Asn Leu Ser
    850                 855                 860                 
Glu Val Lys Ser Ile Phe Ser Lys Ala Gln Ala Glu Tyr Leu Ser Ile
865                 870                 875                 880 
Ser Glu Asp Pro Lys Lys Ala Leu Val Arg Phe Phe Glu Ala Val Gly
                885                 890                 895     
Val Thr Tyr Gly Asn Val Gln Thr Leu Ser Asp Lys Ser Ala Met Val
            900                 905                 910         
Thr Lys Ser Leu Glu Tyr Leu Gly Glu Val Leu Lys Tyr Ile Lys Pro
        915                 920                 925             
Tyr Leu Gly Lys Lys Val Phe Ser Ala Gly Leu Gln Leu Thr Tyr Gly
    930                 935                 940                 
Met Met Gly Ile Leu Val Lys Ser Trp Ala Gln Ile Phe Ala Thr Ser
945                 950                 955                 960 
Lys Ala Gln Lys Leu Leu Phe Arg Ile Ile Asp Cys Leu Leu Leu Pro
                965                 970                 975     
His Ala Val Leu Gln Gln Glu Lys Glu Leu Pro Ala Pro Met Leu Ser
            980                 985                 990         
Ala Ile Gln Lys Ser Leu Pro Leu Tyr Leu Gln Gly Met Cys Ile Val
        995                 1000                1005            
Cys Cys Gln Ser Gln Asn Pro Asn Ala Tyr Leu Asn Gln Leu Leu Gly
    1010                1015                1020                
Asn Val Ile Glu Gln Tyr Ile Gly Arg Phe Leu Pro Ala Ser Pro Tyr
1025                1030                1035                1040
Val Ser Asp Leu Gly Gln His Pro Val Leu Leu Ala Leu Arg Asn Thr
                1045                1050                1055    
Ala Thr Ile Pro Pro Ile Ser Ser Leu Lys Lys Cys Ile Val Gln Val
            1060                1065                1070        
Ile Arg Lys Ser Tyr Leu Glu Tyr Lys Gly Ser Ser Pro Pro Pro Arg
        1075                1080                1085            
Leu Ala Ser Ile Leu Ala Phe Ile Leu Gln Leu Phe Lys Glu Thr Asn
    1090                1095                1100                
Thr Asp Ile Tyr Glu Val Glu Leu Leu Leu Pro Gly Ile Leu Lys Cys
1105                1110                1115                1120
Leu Val Leu Val Ser Glu Pro Gln Val Lys Arg Leu Ala Thr Glu Asn
                1125                1130                1135    
Leu Gln Tyr Met Val Lys Ala Cys Gln Val Gly Ser Glu Glu Glu Pro
            1140                1145                1150        
Ser Ser Gln Leu Thr Ser Val Phe Arg Gln Phe Ile Gln Asp Tyr Gly
        1155                1160                1165            
Met Arg Tyr Tyr Tyr Gln Val Tyr Ser Ile Leu Glu Thr Val Ala Thr
    1170                1175                1180                
Leu Asp Gln Gln Val Val Ile His Leu Ile Ser Thr Leu Thr Gln Ser
1185                1190                1195                1200
Leu Lys Asp Ser Glu Gln Lys Trp Gly Leu Gly Arg Asn Ile Ala Gln
                1205                1210                1215    
Arg Glu Ala Tyr Ser Lys Leu Leu Ser His Leu Gly Gln Met Gly Gln
            1220                1225                1230        
Asp Glu Met Gln Arg Leu Glu Asn Asp Asn Thr
        1235                1240            


<210> 5786
<211> 853
<212> PRT
<213> Homo sapiens

<400> 5786
Met Phe Leu Glu Gly Val Ile Leu Glu Glu Gln Leu Arg Met Tyr Leu
 1               5                  10                  15      
His Cys Cys Leu Thr Leu Cys Asp Phe Trp Glu Pro Asn Ile Ala Ile
            20                  25                  30          
Val Thr Ile Leu Trp Glu Tyr Tyr Ser Lys Asn Leu Asn Ser Ser Phe
        35                  40                  45              
Ser Ile Ser Trp Leu Pro Phe Lys Gly Leu Ala Asn Thr Met Lys Ser
    50                  55                  60                  
Pro Leu Ser Met Leu Glu Met Val Lys Thr Cys Cys Cys Asp Lys Gln
65                  70                  75                  80  
Asp Gln Glu Leu Tyr Lys Ser Ser Ser Ser Tyr Thr Ile Phe Leu Cys
                85                  90                  95      
Ile Leu Ala Lys Val Val Lys Lys Ala Met Lys Ser Asn Gly Pro His
            100                 105                 110         
Pro Trp Lys Gln Val Lys Gly Arg Ile Tyr Ser Lys Phe His Gln Lys
        115                 120                 125             
Arg Met Glu Glu Leu Thr Glu Val Gly Leu Gln Asn Phe Phe Ser Leu
    130                 135                 140                 
Phe Leu Leu Leu Ala Ala Val Ala Glu Val Glu Asp Val Ala Ser His
145                 150                 155                 160 
Val Leu Asp Leu Leu Asn Phe Leu Lys Pro Ala Phe Val Thr Ser Gln
                165                 170                 175     
Arg Ala Leu Ile Trp Lys Gly His Met Ala Phe Leu Leu Met Tyr Ala
            180                 185                 190         
Gln Lys Asn Leu Asp Ile Gly Val Leu Ala Glu Lys Phe Ser Cys Ala
        195                 200                 205             
Phe Arg Glu Lys Ala Lys Glu Phe Leu Val Ser Lys Asn Glu Glu Met
    210                 215                 220                 
Val Gln Arg Gln Thr Ile Trp Thr Leu Leu Ser Ile Tyr Ile Asp Gly
225                 230                 235                 240 
Val Gln Glu Val Phe Glu Thr Ser Tyr Cys Leu Tyr Pro Ser His Glu
                245                 250                 255     
Lys Leu Leu Asn Asp Gly Phe Ser Met Leu Leu Arg Ala Cys Arg Glu
            260                 265                 270         
Ser Glu Leu Arg Thr Val Leu Ser Phe Leu Gln Ala Val Leu Ala Arg
        275                 280                 285             
Ile Arg Ser Met His Gln Gln Leu Cys Gln Glu Leu Gln Arg Asp Asn
    290                 295                 300                 
Val Asp Leu Phe Val Gln Ser Ser Leu Ser Ala Lys Glu Arg His Leu
305                 310                 315                 320 
Ala Ala Val Ala Ser Ala Leu Trp Arg His Phe Phe Ser Phe Leu Lys
                325                 330                 335     
Ser Gln Arg Met Ser Gln Val Val Pro Phe Ser Gln Leu Ala Asp Ala
            340                 345                 350         
Ala Ala Asp Phe Thr Leu Leu Ala Met Asp Met Pro Ser Thr Ala Pro
        355                 360                 365             
Ser Asp Phe Gln Pro Gln Pro Val Ile Ser Ile Ile Gln Leu Phe Gly
    370                 375                 380                 
Trp Asp Asp Ile Ile Cys Pro Gln Val Val Ala Arg Tyr Leu Ser His
385                 390                 395                 400 
Val Leu Gln Asn Ser Thr Leu Cys Glu Ala Leu Ser His Ser Gly Tyr
                405                 410                 415     
Val Ser Phe Gln Ala Leu Thr Val Arg Ser Trp Ile Arg Cys Val Leu
            420                 425                 430         
Gln Met Tyr Ile Lys Asn Leu Ser Gly Pro Asp Asp Leu Leu Ile Asp
        435                 440                 445             
Lys Asn Leu Glu Glu Ala Val Glu Lys Glu Tyr Met Lys Gln Leu Val
    450                 455                 460                 
Lys Leu Thr Arg Leu Leu Phe Asn Leu Ser Glu Val Lys Ser Ile Phe
465                 470                 475                 480 
Ser Lys Ala Gln Val Glu Tyr Leu Ser Ile Ser Glu Asp Pro Lys Lys
                485                 490                 495     
Ala Leu Val Arg Phe Phe Glu Ala Val Gly Val Thr Tyr Gly Asn Val
            500                 505                 510         
Gln Thr Leu Ser Asp Lys Ser Ala Met Val Thr Lys Ser Leu Glu Tyr
        515                 520                 525             
Leu Gly Glu Val Leu Lys Tyr Ile Lys Pro Tyr Leu Gly Lys Lys Val
    530                 535                 540                 
Phe Ser Ala Gly Leu Gln Leu Thr Tyr Gly Met Met Gly Ile Leu Val
545                 550                 555                 560 
Lys Ser Trp Ala Gln Ile Phe Ala Thr Ser Lys Ala Gln Lys Leu Leu
                565                 570                 575     
Phe Arg Ile Ile Asp Cys Leu Leu Leu Pro His Ala Val Leu Gln Gln
            580                 585                 590         
Glu Lys Glu Leu Pro Ala Pro Met Leu Ser Ala Ile Gln Lys Ser Leu
        595                 600                 605             
Pro Leu Tyr Leu Gln Gly Met Cys Ile Val Cys Cys Gln Ser Gln Asn
    610                 615                 620                 
Pro Asn Ala Tyr Leu Asn Gln Leu Leu Gly Asn Val Ile Glu Gln Tyr
625                 630                 635                 640 
Ile Gly Arg Phe Leu Pro Ala Ser Pro Tyr Val Ser Asp Leu Gly Gln
                645                 650                 655     
His Pro Val Leu Leu Ala Leu Arg Asn Thr Ala Thr Ile Pro Pro Ile
            660                 665                 670         
Ser Ser Leu Lys Lys Cys Ile Val Gln Val Ile Arg Lys Ser Tyr Leu
        675                 680                 685             
Glu Tyr Lys Gly Ser Ser Pro Pro Pro Arg Leu Ala Ser Ile Leu Ala
    690                 695                 700                 
Phe Ile Leu Gln Leu Phe Lys Glu Thr Asn Thr Asp Ile Tyr Glu Val
705                 710                 715                 720 
Glu Leu Leu Leu Pro Gly Ile Leu Lys Cys Leu Val Leu Val Ser Glu
                725                 730                 735     
Pro Gln Val Lys Arg Leu Ala Thr Glu Asn Leu Gln Tyr Met Val Lys
            740                 745                 750         
Ala Cys Gln Val Gly Ser Glu Glu Glu Pro Ser Ser Gln Leu Thr Ser
        755                 760                 765             
Val Phe Arg Gln Phe Ile Gln Asp Tyr Gly Met Arg Tyr Tyr Tyr Gln
    770                 775                 780                 
Val Tyr Ser Ile Leu Glu Thr Val Ala Thr Leu Asp Gln Gln Val Val
785                 790                 795                 800 
Ile His Leu Ile Ser Thr Leu Thr Gln Ser Leu Lys Asp Ser Glu Gln
                805                 810                 815     
Lys Trp Gly Leu Gly Arg Asn Ile Ala Gln Arg Glu Ala Tyr Ser Lys
            820                 825                 830         
Leu Leu Ser His Leu Gly Gln Met Gly Gln Asp Glu Met Gln Arg Leu
        835                 840                 845             
Glu Asn Asp Asn Thr
    850             


<210> 5787
<211> 213
<212> PRT
<213> Homo sapiens

<400> 5787
Met Val Thr Gln Phe Lys Glu Lys Asn Glu Ser Leu Gln Tyr Glu Thr
 1               5                  10                  15      
Ser Ser Pro Thr Val Gln Leu Lys Ile Pro Gln Leu Arg Val Ser Ser
            20                  25                  30          
Val Ser Lys Ser Gln Pro Asp Gly Ser Gly Leu Leu Asp Val Met Tyr
        35                  40                  45              
Gln Val Ser Lys Thr Ser Ser Val Leu Glu Gly Ser Ala Leu Gln Lys
    50                  55                  60                  
Leu Lys Asn Ile Leu Pro Lys Gln Asn Lys Ile Glu Cys Ser Gly Pro
65                  70                  75                  80  
Val Thr His Ser Ser Val Asp Ser Tyr Phe Leu His Gly Asp Leu Ser
                85                  90                  95      
Pro Leu Cys Leu Asn Ser Lys Asn Gly Thr Val Asp Gly Thr Ser Glu
            100                 105                 110         
Asn Thr Glu Asp Gly Leu Asp Arg Lys Asp Ser Lys Gln Pro Arg Lys
        115                 120                 125             
Lys Arg Gly Arg Tyr Arg Gln Tyr Asp His Glu Ile Met Glu Glu Ala
    130                 135                 140                 
Ile Ala Met Val Met Ser Gly Lys Met Ser Val Ser Lys Ala Gln Gly
145                 150                 155                 160 
Ile Tyr Gly Val Pro His Ser Thr Leu Glu Tyr Lys Val Lys Glu Arg
                165                 170                 175     
Ser Gly Thr Leu Lys Thr Pro Pro Lys Lys Lys Leu Arg Leu Pro Asp
            180                 185                 190         
Thr Gly Leu Tyr Asn Met Thr Asp Ser Gly Thr Gly Ser Cys Lys Asn
        195                 200                 205             
Ser Ser Lys Pro Val
    210             


<210> 5788
<211> 572
<212> PRT
<213> Homo sapiens

<400> 5788
Ile Arg Asp Thr Tyr Thr Gln Asn Pro Asp Lys Ala Lys Gly Tyr Phe
 1               5                  10                  15      
Ser Cys Ile Phe Phe Glu Ile Glu Glu Thr Thr Met Ser Arg Lys Gln
            20                  25                  30          
Asn Gln Lys Asp Ser Ser Gly Phe Ile Phe Asp Leu Gln Ser Asn Thr
        35                  40                  45              
Val Leu Ala Gln Gly Gly Ala Phe Glu Asn Met Lys Glu Lys Ile Asn
    50                  55                  60                  
Ala Val Arg Ala Ile Val Pro Asn Lys Ser Asn Asn Glu Ile Ile Leu
65                  70                  75                  80  
Val Leu Gln His Phe Asp Asn Cys Val Asp Lys Thr Val Gln Ala Phe
                85                  90                  95      
Met Glu Gly Ser Ala Ser Glu Val Leu Lys Glu Trp Thr Val Thr Gly
            100                 105                 110         
Lys Lys Lys Asn Lys Lys Lys Lys Asn Lys Pro Lys Pro Ala Ala Glu
        115                 120                 125             
Pro Ser Asn Gly Ile Pro Asp Ser Ser Lys Ser Val Ser Ile Gln Glu
    130                 135                 140                 
Glu Gln Ser Ala Pro Ser Ser Glu Lys Gly Gly Met Asn Gly Tyr His
145                 150                 155                 160 
Val Asn Gly Ala Ile Asn Asp Thr Glu Ser Val Asp Ser Leu Ser Glu
                165                 170                 175     
Gly Leu Glu Thr Leu Ser Ile Asp Ala Arg Glu Leu Glu Asp Pro Glu
            180                 185                 190         
Ser Ala Met Leu Asp Thr Leu Asp Arg Thr Gly Ser Met Leu Gln Asn
        195                 200                 205             
Gly Val Ser Asp Phe Glu Thr Lys Ser Leu Thr Met His Ser Ile His
    210                 215                 220                 
Asn Ser Gln Gln Pro Arg Asn Ala Ala Lys Ser Leu Ser Arg Pro Thr
225                 230                 235                 240 
Thr Glu Thr Gln Phe Ser Asn Met Gly Met Glu Asp Val Pro Leu Ala
                245                 250                 255     
Thr Ser Lys Lys Leu Ser Ser Asn Ile Glu Lys Ser Val Lys Asp Leu
            260                 265                 270         
Gln Arg Cys Thr Val Ser Leu Ala Arg Tyr Arg Val Val Val Lys Glu
        275                 280                 285             
Glu Met Asp Ala Ser Ile Lys Lys Met Lys Gln Ala Phe Ala Glu Leu
    290                 295                 300                 
Glu Ser Cys Leu Met Asp Arg Glu Val Ala Leu Leu Ala Glu Met Asp
305                 310                 315                 320 
Lys Val Lys Ala Glu Ala Met Glu Ile Leu Leu Ser Arg Gln Lys Lys
                325                 330                 335     
Ala Glu Leu Leu Lys Lys Met Thr His Val Ala Val Gln Met Ser Glu
            340                 345                 350         
Gln Gln Leu Val Glu Leu Arg Ala Asp Ile Lys His Phe Val Ser Glu
        355                 360                 365             
Arg Lys Tyr Asp Glu Asp Leu Gly Arg Val Ala Arg Phe Thr Cys Asp
    370                 375                 380                 
Val Glu Thr Leu Lys Lys Ser Ile Asp Ser Phe Gly Gln Val Ser His
385                 390                 395                 400 
Pro Lys Asn Ser Tyr Ser Thr Arg Ser Arg Cys Ser Ser Val Thr Ser
                405                 410                 415     
Val Ser Leu Ser Ser Pro Ser Asp Ala Ser Ala Ala Ser Ser Ser Thr
            420                 425                 430         
Cys Ala Ser Pro Pro Ser Leu Thr Ser Ala Asn Lys Lys Asn Phe Ala
        435                 440                 445             
Pro Gly Glu Thr Pro Ala Ala Ile Ala Asn Ser Ser Gly Gln Pro Tyr
    450                 455                 460                 
Gln Pro Leu Arg Glu Val Leu Pro Gly Asn Arg Arg Gly Gly Gln Gly
465                 470                 475                 480 
Tyr Arg Pro Gln Gly Gln Lys Ser Asn Asp Pro Met Asn Gln Gly Arg
                485                 490                 495     
His Asp Ser Met Gly Arg Tyr Arg Asn Ser Ser Trp Tyr Ser Ser Gly
            500                 505                 510         
Ser Arg Tyr Gln Ser Ala Pro Ser Gln Ala Pro Gly Asn Thr Ile Glu
        515                 520                 525             
Arg Gly Gln Thr His Ser Ala Gly Thr Asn Gly Thr Gly Val Ser Met
    530                 535                 540                 
Glu Pro Ser Pro Pro Thr Pro Ser Phe Lys Lys Gly Leu Pro Gln Arg
545                 550                 555                 560 
Lys Pro Arg Thr Ser Gln Thr Glu Ala Val Asn Ser
                565                 570         


<210> 5789
<211> 920
<212> PRT
<213> Homo sapiens

<400> 5789
Arg Cys Gly Ala Gly Gly Tyr Glu Ala Leu Arg Gly Pro Leu Gly Ala
 1               5                  10                  15      
Ala Gly Arg Arg Ala Arg Gln Ala Trp Thr Ile Ala Pro Gly Ser Arg
            20                  25                  30          
Arg Arg Gly Lys Ala Ala Ala Gln Ser Ser Val Pro Gly Ala Gly His
        35                  40                  45              
Ala Gly Gly Gly Ala Ala Pro Arg Arg Pro Ala Ala Ala Val Arg Pro
    50                  55                  60                  
Gly Ser Pro Pro Leu Ala Gly Ala Leu Thr Pro Arg Pro Ser Pro Leu
65                  70                  75                  80  
Gln Gly Pro Phe Pro Gly Arg Leu Leu Ala Gly Pro Pro Pro Arg Phe
                85                  90                  95      
Pro Gly Gly Thr Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr
            100                 105                 110         
Leu Asn Glu Asp Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser
        115                 120                 125             
Ser Gly Tyr Val Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala
    130                 135                 140                 
Glu Ser Asp Gly Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr
145                 150                 155                 160 
Ala Tyr Gln Lys Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu
                165                 170                 175     
Asn Tyr Asp Leu Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu
            180                 185                 190         
Ile Trp Glu Lys Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Asp
        195                 200                 205             
Ile Thr Gln Asp Leu Val Asp Glu Ser Glu Glu Glu Arg Phe Asp Asp
    210                 215                 220                 
Met Ser Ser Pro Gly Leu Glu Leu Pro Ser Cys Glu Leu Ser Arg Leu
225                 230                 235                 240 
Glu Glu Ile Ala Glu Leu Val Ala Ser Ser Leu Pro Ser Pro Leu Arg
                245                 250                 255     
Arg Glu Lys Leu Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys
            260                 265                 270         
Leu Leu Glu Leu Phe His Val Cys Glu Asp Leu Glu Asn Ile Glu Gly
        275                 280                 285             
Leu His His Leu Tyr Glu Ile Ile Lys Gly Ile Phe Leu Leu Asn Arg
    290                 295                 300                 
Thr Ala Leu Phe Glu Val Met Phe Ser Glu Glu Cys Ile Met Asp Val
305                 310                 315                 320 
Ile Gly Cys Leu Glu Tyr Asp Pro Ala Leu Ser Gln Pro Arg Lys His
                325                 330                 335     
Arg Glu Phe Leu Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile
            340                 345                 350         
Ser Asp Pro Glu Leu Lys Gln Lys Ile His Gln Thr Tyr Arg Val Gln
        355                 360                 365             
Tyr Ile Gln Asp Met Val Leu Pro Thr Pro Ser Val Phe Glu Glu Asn
    370                 375                 380                 
Met Leu Ser Thr Leu His Ser Phe Ile Phe Phe Asn Lys Val Glu Ile
385                 390                 395                 400 
Val Gly Met Leu Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala
                405                 410                 415     
Gln Leu Thr Asp Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Val
            420                 425                 430         
Asn Phe Leu Lys Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln
        435                 440                 445             
Asn Arg Asp Ala Phe Phe Lys Thr Leu Ser Asn Met Gly Ile Leu Pro
    450                 455                 460                 
Ala Leu Glu Val Ile Leu Gly Met Asp Asp Thr Gln Val Arg Ser Ala
465                 470                 475                 480 
Ala Thr Asp Ile Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met Val
                485                 490                 495     
Arg Glu Phe Val Met Gln Glu Ala Gln Gln Asn Asp Asp Asp Ile Leu
            500                 505                 510         
Leu Ile Asn Leu Ile Ile Glu His Met Ile Cys Asp Thr Asp Pro Glu
        515                 520                 525             
Leu Gly Gly Ala Val Gln Leu Met Gly Leu Leu Arg Thr Leu Val Asp
    530                 535                 540                 
Pro Glu Asn Met Leu Ala Thr Ala Asn Lys Thr Glu Lys Thr Glu Phe
545                 550                 555                 560 
Leu Gly Phe Phe Tyr Lys His Cys Met His Val Leu Thr Ala Pro Leu
                565                 570                 575     
Leu Ala Asn Thr Thr Glu Asp Lys Pro Ser Lys Asp Asp Phe Gln Thr
            580                 585                 590         
Ala Gln Leu Leu Ala Leu Val Leu Glu Leu Leu Thr Phe Cys Val Glu
        595                 600                 605             
His His Thr Tyr His Ile Lys Asn Tyr Ile Ile Asn Lys Asp Ile Leu
    610                 615                 620                 
Arg Arg Val Leu Val Leu Met Ala Ser Lys His Ala Phe Leu Ala Leu
625                 630                 635                 640 
Cys Ala Leu Arg Phe Lys Arg Lys Ile Ile Gly Leu Lys Asp Glu Phe
                645                 650                 655     
Tyr Asn Arg Tyr Ile Met Lys Ser Phe Leu Phe Glu Pro Val Val Lys
            660                 665                 670         
Ala Phe Leu Asn Asn Gly Ser Arg Tyr Asn Leu Met Asn Ser Ala Ile
        675                 680                 685             
Ile Glu Met Phe Glu Phe Ile Arg Val Glu Asp Ile Lys Ser Leu Thr
    690                 695                 700                 
Ala His Val Ile Glu Asn Tyr Trp Lys Ala Leu Glu Asp Val Asp Tyr
705                 710                 715                 720 
Val Gln Thr Phe Lys Gly Leu Lys Leu Arg Phe Glu Gln Gln Arg Glu
                725                 730                 735     
Arg Gln Asp Asn Pro Lys Leu Asp Ser Met Arg Ser Ile Leu Arg Asn
            740                 745                 750         
His Arg Tyr Arg Arg Asp Ala Arg Thr Leu Glu Asp Glu Glu Glu Met
        755                 760                 765             
Trp Phe Asn Thr Asp Glu Asp Asp Met Glu Asp Gly Glu Ala Val Val
    770                 775                 780                 
Ser Pro Ser Asp Lys Thr Lys Asn Asp Asp Asp Ile Met Asp Pro Ile
785                 790                 795                 800 
Ser Lys Phe Met Glu Arg Lys Lys Leu Lys Glu Ser Glu Glu Lys Glu
                805                 810                 815     
Val Leu Leu Lys Thr Asn Leu Ser Gly Arg Gln Ser Pro Ser Phe Lys
            820                 825                 830         
Leu Ser Leu Ser Ser Gly Thr Lys Thr Asn Leu Thr Ser Gln Ser Ser
        835                 840                 845             
Thr Thr Asn Leu Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser
    850                 855                 860                 
Pro Gly Ser Pro Gly Ser Val Pro Lys Asn Thr Ser Gln Thr Ala Ala
865                 870                 875                 880 
Ile Thr Thr Lys Gly Gly Leu Val Gly Leu Val Asp Tyr Pro Asp Asp
                885                 890                 895     
Asp Glu Asp Asp Asp Glu Asp Glu Asp Lys Glu Asp Thr Leu Pro Leu
            900                 905                 910         
Ser Lys Lys Ala Lys Phe Asp Ser
        915                 920 


<210> 5790
<211> 594
<212> PRT
<213> Homo sapiens

<400> 5790
Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp
 1               5                  10                  15      
Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val
            20                  25                  30          
Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly
        35                  40                  45              
Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys
    50                  55                  60                  
Gln Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr
65                  70                  75                  80  
Asp Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Val Asn Phe Leu
                85                  90                  95      
Lys Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg Asp
            100                 105                 110         
Ala Phe Phe Lys Thr Leu Ser Asn Met Gly Ile Leu Pro Ala Leu Glu
        115                 120                 125             
Val Ile Leu Gly Met Asp Asp Thr Gln Val Arg Ser Ala Ala Thr Asp
    130                 135                 140                 
Ile Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met Val Arg Glu Phe
145                 150                 155                 160 
Val Met Gln Glu Ala Gln Gln Asn Asp Asp Val Ser Lys Lys Leu Thr
                165                 170                 175     
Glu Gln Lys Ile Thr Ser Lys Asp Ile Leu Leu Ile Asn Leu Ile Ile
            180                 185                 190         
Glu His Met Ile Cys Asp Thr Asp Pro Glu Leu Gly Gly Ala Val Gln
        195                 200                 205             
Leu Met Gly Leu Leu Arg Thr Leu Val Asp Pro Glu Asn Met Leu Ala
    210                 215                 220                 
Thr Ala Asn Lys Thr Glu Lys Thr Glu Phe Leu Gly Phe Phe Tyr Lys
225                 230                 235                 240 
His Cys Met His Val Leu Thr Ala Pro Leu Leu Ala Asn Thr Thr Glu
                245                 250                 255     
Asp Lys Pro Ser Lys Asp Asp Phe Gln Thr Ala Gln Leu Leu Ala Leu
            260                 265                 270         
Val Leu Glu Leu Leu Thr Phe Cys Val Glu His His Thr Tyr His Ile
        275                 280                 285             
Lys Asn Tyr Ile Ile Asn Lys Asp Ile Leu Arg Arg Val Leu Val Leu
    290                 295                 300                 
Met Ala Ser Lys His Ala Phe Leu Ala Leu Cys Ala Leu Arg Phe Lys
305                 310                 315                 320 
Arg Lys Ile Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr Ile Met
                325                 330                 335     
Lys Ser Phe Leu Phe Glu Pro Val Val Lys Ala Phe Leu Asn Asn Gly
            340                 345                 350         
Ser Arg Tyr Asn Leu Met Asn Ser Ala Ile Ile Glu Met Phe Glu Phe
        355                 360                 365             
Ile Arg Val Glu Asp Ile Lys Ser Leu Thr Ala His Val Ile Glu Asn
    370                 375                 380                 
Tyr Trp Lys Ala Leu Glu Asp Val Asp Tyr Val Gln Thr Phe Lys Gly
385                 390                 395                 400 
Leu Lys Leu Arg Phe Glu Gln Gln Arg Glu Arg Gln Asp Asn Pro Lys
                405                 410                 415     
Leu Asp Ser Met Arg Ser Ile Leu Arg Asn His Arg Tyr Arg Arg Asp
            420                 425                 430         
Ala Arg Thr Leu Glu Asp Glu Glu Glu Met Trp Phe Asn Thr Asp Glu
        435                 440                 445             
Asp Asp Met Glu Asp Gly Glu Ala Val Val Ser Pro Ser Asp Lys Thr
    450                 455                 460                 
Lys Asn Asp Asp Asp Ile Met Asp Pro Ile Ser Lys Phe Met Glu Arg
465                 470                 475                 480 
Lys Lys Leu Lys Glu Ser Glu Glu Lys Glu Val Leu Leu Lys Thr Asn
                485                 490                 495     
Leu Ser Gly Arg Gln Ser Pro Ser Phe Lys Leu Ser Leu Ser Ser Gly
            500                 505                 510         
Thr Lys Thr Asn Leu Thr Ser Gln Ser Ser Thr Thr Asn Leu Pro Gly
        515                 520                 525             
Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser Pro Gly Ser
    530                 535                 540                 
Val Pro Lys Asn Thr Ser Gln Thr Ala Ala Ile Thr Thr Lys Gly Gly
545                 550                 555                 560 
Leu Val Gly Leu Val Asp Tyr Pro Asp Asp Asp Glu Asp Asp Asp Glu
                565                 570                 575     
Asp Glu Asp Lys Glu Asp Thr Leu Pro Leu Ser Lys Lys Ala Lys Phe
            580                 585                 590         
Asp Ser
        


<210> 5791
<211> 1523
<212> PRT
<213> Homo sapiens

<400> 5791
Val Gln Thr Leu Gly Gly Trp Val Gln Pro Glu Thr Arg Thr Lys Glu
 1               5                  10                  15      
Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr Ile Ile Pro
            20                  25                  30          
Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu Asn Cys Glu
        35                  40                  45              
Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr Gln Pro Glu
    50                  55                  60                  
Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met Thr Arg Asn
65                  70                  75                  80  
Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe Ser Gly Asp
                85                  90                  95      
Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu Pro Arg Asp
            100                 105                 110         
Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro Pro Arg Asp
        115                 120                 125             
Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met Asp Arg Glu
    130                 135                 140                 
Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln Asp Ala Glu
145                 150                 155                 160 
Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys Pro His Asn
                165                 170                 175     
Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu Ser Leu Gly
            180                 185                 190         
Val Gln Leu Ala Glu Asp Asp Gly His Ser His Met Thr Gln Gly His
        195                 200                 205             
Ser Ser Arg Ser Lys Arg Ser Ala Tyr Pro Ser Thr Ser Arg Gly Leu
    210                 215                 220                 
Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His Arg Arg Gly Ile Cys
225                 230                 235                 240 
Glu Asp Glu Ser Ser His Gly Val Ile Met Glu Lys Phe Ile Lys Asp
                245                 250                 255     
Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg Glu Ser Ser Asp Arg
            260                 265                 270         
Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn Trp Lys Asp Ile Ser
        275                 280                 285             
Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg Val Tyr Glu Gly Asn
    290                 295                 300                 
Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr Leu Val Ser Arg Lys
305                 310                 315                 320 
Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe Asp Thr Asp Gly Lys
                325                 330                 335     
Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg Lys Lys Pro Phe Glu
            340                 345                 350         
Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val Ser Ser Leu Ser Ser
        355                 360                 365             
Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro Ile Asp Phe Gly Ala
    370                 375                 380                 
Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser Phe Ser Val Ile Ser
385                 390                 395                 400 
Glu Phe Val Glu His Gln Ile Met His Thr Arg Glu Asn Leu Tyr Glu
                405                 410                 415     
Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val Ser Glu Val Gln Lys
            420                 425                 430         
Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys Asp Cys Gly Glu Thr
        435                 440                 445             
Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg Lys Ile His Ala Arg
    450                 455                 460                 
Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys Glu Glu Ala Phe Met
465                 470                 475                 480 
Pro Ser Pro Thr Phe Ser Glu Leu Gln Lys Ile Tyr Gly Lys Asp Lys
                485                 490                 495     
Phe Tyr Glu Cys Arg Val Cys Lys Glu Thr Phe Leu His Ser Ser Ala
            500                 505                 510         
Leu Ile Glu His Gln Lys Ile His Phe Gly Asp Asp Lys Asp Asn Glu
        515                 520                 525             
Arg Glu His Glu Arg Glu Arg Glu Arg Glu Arg Gly Glu Thr Phe Arg
    530                 535                 540                 
Pro Ser Pro Ala Leu Asn Glu Phe Gln Lys Met Tyr Gly Lys Glu Lys
545                 550                 555                 560 
Met Tyr Glu Cys Lys Val Cys Gly Glu Thr Phe Leu His Ser Ser Ser
                565                 570                 575     
Leu Lys Glu His Gln Lys Ile His Thr Arg Gly Asn Pro Phe Glu Asn
            580                 585                 590         
Lys Gly Lys Val Cys Glu Glu Thr Phe Ile Pro Gly Gln Ser Leu Lys
        595                 600                 605             
Arg Arg Gln Lys Thr Tyr Asn Lys Glu Lys Leu Cys Asp Phe Thr Asp
    610                 615                 620                 
Gly Arg Asp Ala Phe Met Gln Ser Ser Glu Leu Ser Glu His Gln Lys
625                 630                 635                 640 
Ile His Ser Arg Lys Asn Leu Phe Glu Gly Arg Gly Tyr Glu Lys Ser
                645                 650                 655     
Val Ile His Ser Gly Pro Phe Thr Glu Ser Gln Lys Ser His Thr Ile
            660                 665                 670         
Thr Arg Pro Leu Glu Ser Asp Glu Asp Glu Lys Ala Phe Thr Ile Ser
        675                 680                 685             
Ser Asn Pro Tyr Glu Asn Gln Lys Ile Pro Thr Lys Glu Asn Val Tyr
    690                 695                 700                 
Glu Ala Lys Ser Tyr Glu Arg Ser Val Ile His Ser Leu Ala Ser Val
705                 710                 715                 720 
Glu Ala Gln Lys Ser His Ser Val Ala Gly Pro Ser Lys Pro Lys Val
                725                 730                 735     
Met Ala Glu Ser Thr Ile Gln Ser Phe Asp Ala Ile Asn His Gln Arg
            740                 745                 750         
Val Arg Ala Gly Gly Asn Thr Ser Glu Gly Arg Glu Tyr Ser Arg Ser
        755                 760                 765             
Val Ile His Ser Leu Val Ala Ser Lys Pro Pro Arg Ser His Asn Gly
    770                 775                 780                 
Asn Glu Leu Val Glu Ser Asn Glu Lys Gly Glu Ser Ser Ile Tyr Ile
785                 790                 795                 800 
Ser Asp Leu Asn Asp Lys Arg Gln Lys Ile Pro Ala Arg Glu Asn Pro
                805                 810                 815     
Cys Glu Gly Gly Ser Lys Asn Arg Asn Tyr Glu Asp Ser Val Ile Gln
            820                 825                 830         
Ser Val Phe Arg Ala Lys Pro Gln Lys Ser Val Pro Gly Glu Gly Ser
        835                 840                 845             
Gly Glu Phe Lys Lys Asp Gly Glu Phe Ser Val Pro Ser Ser Asn Val
    850                 855                 860                 
Arg Glu Tyr Gln Lys Ala Arg Ala Lys Lys Lys Tyr Ile Glu His Arg
865                 870                 875                 880 
Ser Asn Glu Thr Ser Val Ile His Ser Leu Pro Phe Gly Glu Gln Thr
                885                 890                 895     
Phe Arg Pro Arg Gly Met Leu Tyr Glu Cys Gln Glu Cys Gly Glu Cys
            900                 905                 910         
Phe Ala His Ser Ser Asp Leu Thr Glu His Gln Lys Ile His Asp Arg
        915                 920                 925             
Glu Lys Pro Ser Gly Ser Arg Asn Tyr Glu Trp Ser Val Ile Arg Ser
    930                 935                 940                 
Leu Ala Pro Thr Asp Pro Gln Thr Ser Tyr Ala Gln Glu Gln Tyr Ala
945                 950                 955                 960 
Lys Glu Gln Ala Arg Asn Lys Cys Lys Asp Phe Arg Gln Phe Phe Ala
                965                 970                 975     
Thr Ser Glu Asp Leu Asn Thr Asn Gln Lys Ile Tyr Asp Gln Glu Lys
            980                 985                 990         
Ser His Gly Glu Glu Ser Gln Gly Glu Asn Thr Asp Gly Glu Glu Thr
        995                 1000                1005            
His Ser Glu Glu Thr His Gly Gln Glu Thr Ile Glu Asp Pro Val Ile
    1010                1015                1020                
Gln Gly Ser Asp Met Glu Asp Pro Gln Lys Asp Asp Pro Asp Asp Lys
1025                1030                1035                1040
Ile Tyr Glu Cys Glu Asp Cys Gly Leu Gly Phe Val Asp Leu Thr Asp
                1045                1050                1055    
Leu Thr Asp His Gln Lys Val His Ser Arg Lys Cys Leu Val Asp Ser
            1060                1065                1070        
Arg Glu Tyr Thr His Ser Val Ile His Thr His Ser Ile Ser Glu Tyr
        1075                1080                1085            
Gln Arg Asp Tyr Thr Gly Glu Gln Leu Tyr Glu Cys Pro Lys Cys Gly
    1090                1095                1100                
Glu Ser Phe Ile His Ser Ser Phe Leu Phe Glu His Gln Arg Ile His
1105                1110                1115                1120
Glu Gln Asp Gln Leu Tyr Ser Met Lys Gly Cys Asp Asp Gly Phe Ile
                1125                1130                1135    
Ala Leu Leu Pro Met Lys Pro Arg Arg Asn Arg Ala Ala Glu Arg Asn
            1140                1145                1150        
Pro Ala Leu Ala Gly Ser Ala Ile Arg Cys Leu Leu Cys Gly Gln Gly
        1155                1160                1165            
Phe Ile His Ser Ser Ala Leu Asn Glu His Met Arg Leu His Arg Glu
    1170                1175                1180                
Asp Asp Leu Leu Glu Gln Ser Gln Met Ala Glu Glu Ala Ile Ile Pro
1185                1190                1195                1200
Gly Leu Ala Leu Thr Glu Phe Gln Arg Ser Gln Thr Glu Glu Arg Leu
                1205                1210                1215    
Phe Glu Cys Ala Val Cys Gly Glu Ser Phe Val Asn Pro Ala Glu Leu
            1220                1225                1230        
Ala Asp His Val Thr Val His Lys Asn Glu Pro Tyr Glu Tyr Gly Ser
        1235                1240                1245            
Ser Tyr Thr His Thr Ser Phe Leu Thr Glu Pro Leu Lys Gly Ala Ile
    1250                1255                1260                
Pro Phe Tyr Glu Cys Lys Asp Cys Gly Lys Ser Phe Ile His Ser Thr
1265                1270                1275                1280
Val Leu Thr Lys His Lys Glu Leu His Leu Glu Glu Glu Glu Glu Asp
                1285                1290                1295    
Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Glu Val Glu Ala Asn
            1300                1305                1310        
Val His Val Pro Gln Val Val Leu Arg Ile Gln Gly Leu Asn Val Glu
        1315                1320                1325            
Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Glu Val Glu Ala Ala
    1330                1335                1340                
Glu Pro Glu Val Glu Ala Ala Glu Pro Asn Gly Glu Ala Glu Gly Pro
1345                1350                1355                1360
Asp Gly Glu Ala Ala Glu Pro Ile Gly Glu Ala Gly Gln Pro Asn Gly
                1365                1370                1375    
Glu Ala Glu Gln Pro Asn Gly Asp Ala Asp Glu Pro Asp Gly Ala Gly
            1380                1385                1390        
Ile Glu Asp Pro Glu Glu Arg Ala Glu Glu Pro Glu Gly Lys Ala Glu
        1395                1400                1405            
Glu Pro Glu Gly Asp Ala Asp Glu Pro Asp Gly Val Gly Ile Glu Asp
    1410                1415                1420                
Pro Glu Glu Gly Glu Asp Gln Glu Ile Gln Val Glu Glu Pro Tyr Tyr
1425                1430                1435                1440
Asp Cys His Glu Cys Thr Glu Thr Phe Thr Ser Ser Thr Ala Phe Ser
                1445                1450                1455    
Glu His Leu Lys Thr His Ala Ser Met Ile Ile Phe Glu Pro Ala Asn
            1460                1465                1470        
Ala Phe Gly Glu Cys Ser Gly Tyr Ile Glu Arg Ala Ser Thr Ser Thr
        1475                1480                1485            
Gly Gly Ala Asn Gln Ala Asp Glu Lys Tyr Phe Lys Cys Asp Val Cys
    1490                1495                1500                
Gly Gln Leu Phe Asn Asp Arg Leu Ser Leu Ala Arg His Gln Asn Thr
1505                1510                1515                1520
His Thr Gly
            


<210> 5792
<211> 518
<212> PRT
<213> Homo sapiens

<400> 5792
Pro Lys His Leu Ser Ala Thr Lys Pro Lys Lys Ser Trp Ala Pro Asn
 1               5                  10                  15      
Leu Tyr Glu Leu Asp Ser Asp Leu Thr Lys Glu Pro Asp Val Ile Ile
            20                  25                  30          
Gly Glu Gly Pro Thr Asp Ser Glu Phe Phe His Gln Arg Phe Arg Asn
        35                  40                  45              
Leu Ile Tyr Val Glu Phe Val Gly Pro Arg Lys Thr Leu Ile Lys Leu
    50                  55                  60                  
Arg Asn Leu Cys Leu Asp Trp Leu Gln Pro Glu Thr Arg Thr Lys Glu
65                  70                  75                  80  
Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr Ile Ile Pro
                85                  90                  95      
Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu Asn Cys Glu
            100                 105                 110         
Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr Gln Pro Glu
        115                 120                 125             
Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met Thr Arg Asn
    130                 135                 140                 
Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe Ser Gly Asp
145                 150                 155                 160 
Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu Pro Arg Asp
                165                 170                 175     
Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro Pro Arg Asp
            180                 185                 190         
Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met Asp Arg Glu
        195                 200                 205             
Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln Asp Ala Glu
    210                 215                 220                 
Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys Pro His Asn
225                 230                 235                 240 
Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu Ser Leu Gly
                245                 250                 255     
Leu Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His Arg Arg Gly Ile
            260                 265                 270         
Cys Glu Asp Glu Ser Ser His Gly Val Ile Met Glu Lys Phe Ile Lys
        275                 280                 285             
Asp Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg Glu Ser Ser Asp
    290                 295                 300                 
Arg Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn Trp Lys Asp Ile
305                 310                 315                 320 
Ser Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg Val Tyr Glu Gly
                325                 330                 335     
Asn Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr Leu Val Ser Arg
            340                 345                 350         
Lys Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe Asp Thr Asp Gly
        355                 360                 365             
Lys Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg Lys Lys Pro Phe
    370                 375                 380                 
Glu Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val Ser Ser Leu Ser
385                 390                 395                 400 
Ser Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro Ile Asp Phe Gly
                405                 410                 415     
Ala Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser Phe Ser Val Ile
            420                 425                 430         
Ser Glu Phe Val Glu His Gln Ile Met His Thr Arg Glu Asn Leu Tyr
        435                 440                 445             
Glu Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val Ser Glu Val Gln
    450                 455                 460                 
Lys Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys Asp Cys Gly Glu
465                 470                 475                 480 
Thr Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg Lys Ile His Ala
                485                 490                 495     
Arg Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys Glu Glu Ala Phe
            500                 505                 510         
Met Pro Asn Pro Cys Leu
        515             


<210> 5793
<211> 1590
<212> PRT
<213> Homo sapiens

<400> 5793
Met Leu Pro Pro Lys His Leu Ser Ala Thr Lys Pro Lys Lys Ser Trp
 1               5                  10                  15      
Ala Pro Asn Leu Tyr Glu Leu Asp Ser Asp Leu Thr Lys Glu Pro Asp
            20                  25                  30          
Val Ile Ile Gly Glu Gly Pro Thr Asp Ser Glu Phe Phe His Gln Arg
        35                  40                  45              
Phe Arg Asn Leu Ile Tyr Val Glu Phe Val Gly Pro Arg Lys Thr Leu
    50                  55                  60                  
Ile Lys Leu Arg Asn Leu Cys Leu Asp Trp Leu Gln Pro Glu Thr Arg
65                  70                  75                  80  
Thr Lys Glu Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr
                85                  90                  95      
Ile Ile Pro Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu
            100                 105                 110         
Asn Cys Glu Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr
        115                 120                 125             
Gln Pro Glu Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met
    130                 135                 140                 
Thr Arg Asn Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe
145                 150                 155                 160 
Ser Gly Asp Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu
                165                 170                 175     
Pro Arg Asp Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro
            180                 185                 190         
Pro Arg Asp Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met
        195                 200                 205             
Asp Arg Glu Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln
    210                 215                 220                 
Asp Ala Glu Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys
225                 230                 235                 240 
Pro His Asn Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu
                245                 250                 255     
Ser Leu Gly Val Gln Leu Ala Glu Asp Asp Gly His Ser His Met Thr
            260                 265                 270         
Gln Gly His Ser Ser Arg Ser Lys Arg Ser Ala Tyr Pro Ser Thr Ser
        275                 280                 285             
Arg Gly Leu Lys Thr Met Pro Glu Ala Lys Lys Ser Thr His Arg Arg
    290                 295                 300                 
Gly Ile Cys Glu Asp Glu Ser Ser His Gly Val Ile Met Glu Lys Phe
305                 310                 315                 320 
Ile Lys Asp Val Ser Arg Ser Ser Lys Ser Gly Arg Ala Arg Glu Ser
                325                 330                 335     
Ser Asp Arg Ser Gln Arg Phe Pro Arg Met Ser Asp Asp Asn Trp Lys
            340                 345                 350         
Asp Ile Ser Leu Asn Lys Arg Glu Ser Val Ile Gln Gln Arg Val Tyr
        355                 360                 365             
Glu Gly Asn Ala Phe Arg Gly Gly Phe Arg Phe Asn Ser Thr Leu Val
    370                 375                 380                 
Ser Arg Lys Arg Val Leu Glu Arg Lys Arg Arg Tyr His Phe Asp Thr
385                 390                 395                 400 
Asp Gly Lys Gly Ser Ile His Asp Gln Lys Gly Cys Pro Arg Lys Lys
                405                 410                 415     
Pro Phe Glu Cys Gly Ser Glu Met Arg Lys Ala Met Ser Val Ser Ser
            420                 425                 430         
Leu Ser Ser Leu Ser Ser Pro Ser Phe Thr Glu Ser Gln Pro Ile Asp
        435                 440                 445             
Phe Gly Ala Met Pro Tyr Val Cys Asp Glu Cys Gly Arg Ser Phe Ser
    450                 455                 460                 
Val Ile Ser Glu Phe Val Glu His Gln Ile Met His Thr Arg Glu Asn
465                 470                 475                 480 
Leu Tyr Glu Tyr Gly Glu Ser Phe Ile His Ser Val Ala Val Ser Glu
                485                 490                 495     
Val Gln Lys Ser Gln Val Gly Gly Lys Arg Phe Glu Cys Lys Asp Cys
            500                 505                 510         
Gly Glu Thr Phe Asn Lys Ser Ala Ala Leu Ala Glu His Arg Lys Ile
        515                 520                 525             
His Ala Arg Gly Tyr Leu Val Glu Cys Lys Asn Gln Glu Cys Glu Glu
    530                 535                 540                 
Ala Phe Met Pro Ser Pro Thr Phe Ser Glu Leu Gln Lys Ile Tyr Gly
545                 550                 555                 560 
Lys Asp Lys Phe Tyr Glu Cys Arg Val Cys Lys Glu Thr Phe Leu His
                565                 570                 575     
Ser Ser Ala Leu Ile Glu His Gln Lys Ile His Phe Gly Asp Asp Lys
            580                 585                 590         
Asp Asn Glu Arg Glu His Glu Arg Glu Arg Glu Arg Glu Arg Gly Glu
        595                 600                 605             
Thr Phe Arg Pro Ser Pro Ala Leu Asn Glu Phe Gln Lys Met Tyr Gly
    610                 615                 620                 
Lys Glu Lys Met Tyr Glu Cys Lys Val Cys Gly Glu Thr Phe Leu His
625                 630                 635                 640 
Ser Ser Ser Leu Lys Glu His Gln Lys Ile His Thr Arg Gly Asn Pro
                645                 650                 655     
Phe Glu Asn Lys Gly Lys Val Cys Glu Glu Thr Phe Ile Pro Gly Gln
            660                 665                 670         
Ser Leu Lys Arg Arg Gln Lys Thr Tyr Asn Lys Glu Lys Leu Cys Asp
        675                 680                 685             
Phe Thr Asp Gly Arg Asp Ala Phe Met Gln Ser Ser Glu Leu Ser Glu
    690                 695                 700                 
His Gln Lys Ile His Ser Arg Lys Asn Leu Phe Glu Gly Arg Gly Tyr
705                 710                 715                 720 
Glu Lys Ser Val Ile His Ser Gly Pro Phe Thr Glu Ser Gln Lys Ser
                725                 730                 735     
His Thr Ile Thr Arg Pro Leu Glu Ser Asp Glu Asp Glu Lys Ala Phe
            740                 745                 750         
Thr Ile Ser Ser Asn Pro Tyr Glu Asn Gln Lys Ile Pro Thr Lys Glu
        755                 760                 765             
Asn Val Tyr Glu Ala Lys Ser Tyr Glu Arg Ser Val Ile His Ser Leu
    770                 775                 780                 
Ala Ser Val Glu Ala Gln Lys Ser His Ser Val Ala Gly Pro Ser Lys
785                 790                 795                 800 
Pro Lys Val Met Ala Glu Ser Thr Ile Gln Ser Phe Asp Ala Ile Asn
                805                 810                 815     
His Gln Arg Val Arg Ala Gly Gly Asn Thr Ser Glu Gly Arg Glu Tyr
            820                 825                 830         
Ser Arg Ser Val Ile His Ser Leu Val Ala Ser Lys Pro Pro Arg Ser
        835                 840                 845             
His Asn Gly Asn Glu Leu Val Glu Ser Asn Glu Lys Gly Glu Ser Ser
    850                 855                 860                 
Ile Tyr Ile Ser Asp Leu Asn Asp Lys Arg Gln Lys Ile Pro Ala Arg
865                 870                 875                 880 
Glu Asn Pro Cys Glu Gly Gly Ser Lys Asn Arg Asn Tyr Glu Asp Ser
                885                 890                 895     
Val Ile Gln Ser Val Phe Arg Ala Lys Pro Gln Lys Ser Val Pro Gly
            900                 905                 910         
Glu Gly Ser Gly Glu Phe Lys Lys Asp Gly Glu Phe Ser Val Pro Ser
        915                 920                 925             
Ser Asn Val Arg Glu Tyr Gln Lys Ala Arg Ala Lys Lys Lys Tyr Ile
    930                 935                 940                 
Glu His Arg Ser Asn Glu Thr Ser Val Ile His Ser Leu Pro Phe Gly
945                 950                 955                 960 
Glu Gln Thr Phe Arg Pro Arg Gly Met Leu Tyr Glu Cys Gln Glu Cys
                965                 970                 975     
Gly Glu Cys Phe Ala His Ser Ser Asp Leu Thr Glu His Gln Lys Ile
            980                 985                 990         
His Asp Arg Glu Lys Pro Ser Gly Ser Arg Asn Tyr Glu Trp Ser Val
        995                 1000                1005            
Ile Arg Ser Leu Ala Pro Thr Asp Pro Gln Thr Ser Tyr Ala Gln Glu
    1010                1015                1020                
Gln Tyr Ala Lys Glu Gln Ala Arg Asn Lys Cys Lys Asp Phe Arg Gln
1025                1030                1035                1040
Phe Phe Ala Thr Ser Glu Asp Leu Asn Thr Asn Gln Lys Ile Tyr Asp
                1045                1050                1055    
Gln Glu Lys Ser His Gly Glu Glu Ser Gln Gly Glu Asn Thr Asp Gly
            1060                1065                1070        
Glu Glu Thr His Ser Glu Glu Thr His Gly Gln Glu Thr Ile Glu Asp
        1075                1080                1085            
Pro Val Ile Gln Gly Ser Asp Met Glu Asp Pro Gln Lys Asp Asp Pro
    1090                1095                1100                
Asp Asp Lys Ile Tyr Glu Cys Glu Asp Cys Gly Leu Gly Phe Val Asp
1105                1110                1115                1120
Leu Thr Asp Leu Thr Asp His Gln Lys Val His Ser Arg Lys Cys Leu
                1125                1130                1135    
Val Asp Ser Arg Glu Tyr Thr His Ser Val Ile His Thr His Ser Ile
            1140                1145                1150        
Ser Glu Tyr Gln Arg Asp Tyr Thr Gly Glu Gln Leu Tyr Glu Cys Pro
        1155                1160                1165            
Lys Cys Gly Glu Ser Phe Ile His Ser Ser Phe Leu Phe Glu His Gln
    1170                1175                1180                
Arg Ile His Glu Gln Asp Gln Leu Tyr Ser Met Lys Gly Cys Asp Asp
1185                1190                1195                1200
Gly Phe Ile Ala Leu Leu Pro Met Lys Pro Arg Arg Asn Arg Ala Ala
                1205                1210                1215    
Glu Arg Asn Pro Ala Leu Ala Gly Ser Ala Ile Arg Cys Leu Leu Cys
            1220                1225                1230        
Gly Gln Gly Phe Ile His Ser Ser Ala Leu Asn Glu His Met Arg Leu
        1235                1240                1245            
His Arg Glu Asp Asp Leu Leu Glu Gln Ser Gln Met Ala Glu Glu Ala
    1250                1255                1260                
Ile Ile Pro Gly Leu Ala Leu Thr Glu Phe Gln Arg Ser Gln Thr Glu
1265                1270                1275                1280
Glu Arg Leu Phe Glu Cys Ala Val Cys Gly Glu Ser Phe Val Asn Pro
                1285                1290                1295    
Ala Glu Leu Ala Asp His Val Thr Val His Lys Asn Glu Pro Tyr Glu
            1300                1305                1310        
Tyr Gly Ser Ser Tyr Thr His Thr Ser Phe Leu Thr Glu Pro Leu Lys
        1315                1320                1325            
Gly Ala Ile Pro Phe Tyr Glu Cys Lys Asp Cys Gly Lys Ser Phe Ile
    1330                1335                1340                
His Ser Thr Val Leu Thr Lys His Lys Glu Leu His Leu Glu Glu Glu
1345                1350                1355                1360
Glu Glu Asp Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Glu Val
                1365                1370                1375    
Glu Ala Asn Val His Val Pro Gln Val Val Leu Arg Ile Gln Gly Leu
            1380                1385                1390        
Asn Val Glu Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Glu Val
        1395                1400                1405            
Glu Ala Ala Glu Pro Glu Val Glu Ala Ala Glu Pro Asn Gly Glu Ala
    1410                1415                1420                
Glu Gly Pro Asp Gly Glu Ala Ala Glu Pro Ile Gly Glu Ala Gly Gln
1425                1430                1435                1440
Pro Asn Gly Glu Ala Glu Gln Pro Asn Gly Asp Ala Asp Glu Pro Asp
                1445                1450                1455    
Gly Ala Gly Ile Glu Asp Pro Glu Glu Arg Ala Glu Glu Pro Glu Gly
            1460                1465                1470        
Lys Ala Glu Glu Pro Glu Gly Asp Ala Asp Glu Pro Asp Gly Val Gly
        1475                1480                1485            
Ile Glu Asp Pro Glu Glu Gly Glu Asp Gln Glu Ile Gln Val Glu Glu
    1490                1495                1500                
Pro Tyr Tyr Asp Cys His Glu Cys Thr Glu Thr Phe Thr Ser Ser Thr
1505                1510                1515                1520
Ala Phe Ser Glu His Leu Lys Thr His Ala Ser Met Ile Ile Phe Glu
                1525                1530                1535    
Pro Ala Asn Ala Phe Gly Glu Cys Ser Gly Tyr Ile Glu Arg Ala Ser
            1540                1545                1550        
Thr Ser Thr Gly Gly Ala Asn Gln Ala Asp Glu Lys Tyr Phe Lys Cys
        1555                1560                1565            
Asp Val Cys Gly Gln Leu Phe Asn Asp Arg Leu Ser Leu Ala Arg His
    1570                1575                1580                
Gln Asn Thr His Thr Gly
1585                1590


<210> 5794
<211> 586
<212> PRT
<213> Homo sapiens

<400> 5794
Val Gln Thr Leu Gly Gly Trp Val Gln Pro Glu Thr Arg Thr Lys Glu
 1               5                  10                  15      
Glu Ile Ile Glu Leu Leu Val Leu Glu Gln Tyr Leu Thr Ile Ile Pro
            20                  25                  30          
Glu Lys Leu Lys Pro Trp Val Arg Ala Lys Lys Pro Glu Asn Cys Glu
        35                  40                  45              
Lys Leu Val Thr Leu Leu Glu Asn Tyr Lys Glu Met Tyr Gln Pro Glu
    50                  55                  60                  
Asp Asp Asn Asn Ser Asp Val Thr Ser Asp Asp Asp Met Thr Arg Asn
65                  70                  75                  80  
Arg Arg Glu Ser Ser Pro Pro His Ser Val His Ser Phe Ser Gly Asp
                85                  90                  95      
Arg Asp Trp Asp Arg Arg Gly Arg Ser Arg Asp Met Glu Pro Arg Asp
            100                 105                 110         
Arg Trp Ser His Thr Arg Asn Pro Arg Ser Arg Met Pro Pro Arg Asp
        115                 120                 125             
Leu Ser Leu Pro Val Val Ala Lys Thr Ser Phe Glu Met Asp Arg Glu
    130                 135                 140                 
Asp Asp Arg Asp Ser Arg Ala Tyr Glu Ser Arg Ser Gln Asp Ala Glu
145                 150                 155                 160 
Ser Tyr Gln Asn Val Val Asp Leu Ala Glu Asp Arg Lys Pro His Asn
                165                 170                 175     
Thr Ile Gln Asp Asn Met Glu Asn Tyr Arg Lys Leu Leu Ser Leu Gly
            180                 185                 190         
Phe Leu Ala Gln Asp Ser Val Pro Ala Glu Lys Arg Asn Thr Glu Met
        195                 200                 205             
Leu Asp Asn Leu Pro Ser Ala Gly Ser Gln Phe Pro Asp Phe Lys His
    210                 215                 220                 
Leu Gly Thr Phe Leu Val Phe Glu Glu Leu Val Thr Phe Glu Asp Val
225                 230                 235                 240 
Leu Val Asp Phe Ser Pro Glu Glu Leu Ser Ser Leu Ser Ala Ala Gln
                245                 250                 255     
Arg Asn Leu Tyr Arg Glu Val Met Leu Glu Asn Tyr Arg Asn Leu Val
            260                 265                 270         
Ser Leu Gly His Gln Phe Ser Lys Pro Asp Ile Ile Ser Arg Leu Glu
        275                 280                 285             
Glu Glu Glu Ser Tyr Ala Met Glu Thr Asp Ser Arg His Thr Val Ile
    290                 295                 300                 
Cys Gln Gly Glu Ser His Asp Asp Pro Leu Glu Pro His Gln Gly Asn
305                 310                 315                 320 
Gln Glu Lys Leu Leu Thr Pro Ile Thr Met Asn Asp Pro Lys Thr Leu
                325                 330                 335     
Thr Pro Glu Arg Ser Tyr Gly Ser Asp Glu Phe Glu Arg Ser Ser Asn
            340                 345                 350         
Leu Ser Lys Gln Ser Lys Asp Pro Leu Gly Lys Asp Pro Gln Glu Gly
        355                 360                 365             
Thr Ala Pro Gly Ile Cys Thr Ser Pro Gln Ser Ala Ser Gln Glu Asn
    370                 375                 380                 
Lys His Asn Arg Cys Glu Phe Cys Lys Arg Thr Phe Ser Thr Gln Val
385                 390                 395                 400 
Ala Leu Arg Arg His Glu Arg Ile His Thr Gly Lys Lys Pro Tyr Glu
                405                 410                 415     
Cys Lys Gln Cys Ala Glu Ala Phe Tyr Leu Met Pro His Leu Asn Arg
            420                 425                 430         
His Gln Lys Thr His Ser Gly Arg Lys Thr Ser Gly Cys Asn Glu Gly
        435                 440                 445             
Arg Lys Pro Ser Val Gln Cys Ala Asn Leu Cys Glu Arg Val Arg Ile
    450                 455                 460                 
His Ser Gln Glu Asp Tyr Phe Glu Cys Phe Gln Cys Gly Lys Ala Phe
465                 470                 475                 480 
Leu Gln Asn Val His Leu Leu Gln His Leu Lys Ala His Glu Ala Ala
                485                 490                 495     
Arg Val Leu Pro Pro Gly Leu Ser His Ser Lys Thr Tyr Leu Ile Arg
            500                 505                 510         
Tyr Gln Arg Lys His Asp Tyr Val Gly Glu Arg Ala Cys Gln Cys Cys
        515                 520                 525             
Asp Cys Gly Arg Val Phe Ser Arg Asn Ser Tyr Leu Ile Gln His Tyr
    530                 535                 540                 
Arg Thr His Thr Gln Glu Arg Pro Tyr Gln Cys Gln Leu Cys Gly Lys
545                 550                 555                 560 
Cys Phe Gly Arg Pro Ser Tyr Leu Thr Gln His Tyr Gln Leu His Ser
                565                 570                 575     
Gln Glu Lys Thr Val Glu Cys Asp His Cys
            580                 585     


<210> 5795
<211> 1148
<212> PRT
<213> Homo sapiens

<400> 5795
Met Glu Ser Leu Leu Leu Pro Val Leu Leu Leu Leu Ala Ile Leu Trp
 1               5                  10                  15      
Thr Gln Ala Ala Ala Leu Ile Asn Leu Lys Tyr Ser Val Glu Glu Glu
            20                  25                  30          
Gln Arg Ala Gly Thr Val Ile Ala Asn Val Ala Lys Asp Ala Arg Glu
        35                  40                  45              
Ala Gly Phe Ala Leu Asp Pro Arg Gln Ala Ser Ala Phe Arg Val Val
    50                  55                  60                  
Ser Asn Ser Ala Pro His Leu Val Asp Ile Asn Pro Ser Ser Gly Leu
65                  70                  75                  80  
Leu Val Thr Lys Gln Lys Ile Asp Arg Asp Leu Leu Cys Arg Gln Ser
                85                  90                  95      
Pro Lys Cys Ile Ile Ser Leu Glu Val Met Ser Ser Ser Met Glu Ile
            100                 105                 110         
Cys Val Ile Lys Val Glu Ile Lys Asp Leu Asn Asp Asn Ala Pro Ser
        115                 120                 125             
Phe Pro Ala Ala Gln Ile Glu Leu Glu Ile Ser Glu Ala Ala Ser Pro
    130                 135                 140                 
Gly Thr Arg Ile Pro Leu Asp Ser Ala Tyr Asp Pro Asp Ser Gly Ser
145                 150                 155                 160 
Phe Gly Val Gln Thr Tyr Glu Leu Thr Pro Asn Glu Leu Phe Gly Leu
                165                 170                 175     
Glu Ile Lys Thr Arg Gly Asp Gly Ser Arg Phe Ala Glu Leu Val Val
            180                 185                 190         
Glu Lys Ser Leu Asp Arg Glu Thr Gln Ser His Tyr Ser Phe Arg Ile
        195                 200                 205             
Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Leu Gly Thr Val Gly Leu
    210                 215                 220                 
Ser Ile Lys Val Thr Asp Ser Asn Asp Asn Asn Pro Val Phe Ser Glu
225                 230                 235                 240 
Ser Thr Tyr Ala Val Ser Val Pro Glu Asn Ser Pro Pro Asn Thr Pro
                245                 250                 255     
Val Ile Arg Leu Asn Ala Ser Asp Pro Asp Glu Gly Thr Asn Gly Gln
            260                 265                 270         
Val Val Tyr Ser Phe Tyr Gly Tyr Val Asn Asp Arg Thr Arg Glu Leu
        275                 280                 285             
Phe Gln Ile Asp Pro His Ser Gly Leu Val Thr Val Thr Gly Ala Leu
    290                 295                 300                 
Asp Tyr Glu Glu Gly His Val Tyr Glu Leu Asp Val Gln Ala Lys Asp
305                 310                 315                 320 
Leu Gly Pro Asn Ser Ile Pro Ala His Cys Lys Val Thr Val Ser Val
                325                 330                 335     
Leu Asp Thr Asn Asp Asn Pro Pro Val Ile Asn Leu Leu Ser Val Asn
            340                 345                 350         
Ser Glu Leu Val Glu Val Ser Glu Ser Ala Pro Pro Gly Tyr Val Ile
        355                 360                 365             
Ala Leu Val Arg Val Ser Asp Arg Asp Ser Gly Leu Asn Gly Arg Val
    370                 375                 380                 
Gln Cys Arg Leu Leu Gly Asn Val Pro Phe Arg Leu Gln Glu Tyr Glu
385                 390                 395                 400 
Ser Phe Ser Thr Ile Leu Val Asp Gly Arg Leu Asp Arg Glu Gln His
                405                 410                 415     
Asp Gln Tyr Asn Leu Thr Ile Gln Ala Arg Asp Gly Gly Val Pro Met
            420                 425                 430         
Leu Gln Ser Ala Lys Ser Phe Thr Val Leu Ile Thr Asp Glu Asn Asp
        435                 440                 445             
Asn His Pro His Phe Ser Lys Pro Tyr Tyr Gln Val Ile Val Gln Glu
    450                 455                 460                 
Asn Asn Thr Pro Gly Ala Tyr Leu Leu Ser Val Ser Ala Arg Asp Pro
465                 470                 475                 480 
Asp Leu Gly Leu Asn Gly Ser Val Ser Tyr Gln Ile Val Pro Ser Gln
                485                 490                 495     
Val Arg Asp Met Pro Val Phe Thr Tyr Val Ser Ile Asn Pro Asn Ser
            500                 505                 510         
Gly Asp Ile Tyr Ala Leu Arg Ser Phe Asn His Glu Gln Thr Lys Ala
        515                 520                 525             
Phe Glu Phe Lys Val Leu Ala Lys Asp Gly Gly Leu Pro Ser Leu Gln
    530                 535                 540                 
Ser Asn Ala Thr Val Arg Val Ile Ile Leu Asp Val Asn Asp Asn Thr
545                 550                 555                 560 
Pro Val Ile Thr Ala Pro Pro Leu Ile Asn Gly Thr Ala Glu Val Tyr
                565                 570                 575     
Ile Pro Arg Asn Ser Gly Ile Gly Tyr Leu Val Thr Val Val Lys Ala
            580                 585                 590         
Glu Asp Tyr Asp Glu Gly Glu Asn Gly Arg Val Thr Tyr Asp Met Thr
        595                 600                 605             
Glu Gly Asp Arg Gly Phe Phe Glu Ile Asp Gln Val Asn Gly Glu Val
    610                 615                 620                 
Arg Thr Thr Arg Thr Phe Gly Glu Ser Ser Lys Ser Ser Tyr Glu Leu
625                 630                 635                 640 
Ile Val Val Ala His Asp His Gly Lys Thr Ser Leu Ser Ala Ser Ala
                645                 650                 655     
Leu Val Leu Ile Tyr Leu Ser Pro Ala Leu Asp Ala Gln Glu Ser Met
            660                 665                 670         
Gly Ser Val Asn Leu Ser Leu Ile Phe Ile Ile Ala Leu Gly Ser Ile
        675                 680                 685             
Ala Gly Ile Leu Phe Val Thr Met Ile Phe Val Ala Ile Lys Cys Lys
    690                 695                 700                 
Arg Asp Asn Lys Glu Ile Arg Thr Tyr Asn Cys Ser Asn Cys Leu Thr
705                 710                 715                 720 
Ile Thr Cys Leu Leu Gly Cys Phe Ile Lys Gly Gln Asn Ser Lys Cys
                725                 730                 735     
Leu His Cys Ile Ser Val Ser Pro Ile Ser Glu Glu Gln Asp Lys Lys
            740                 745                 750         
Thr Glu Glu Lys Val Ser Leu Arg Gly Lys Arg Ile Ala Glu Tyr Ser
        755                 760                 765             
Tyr Gly His Gln Lys Lys Ser Ser Lys Lys Lys Lys Ile Ser Lys Asn
    770                 775                 780                 
Asp Ile Arg Leu Val Pro Arg Asp Val Glu Glu Thr Asp Lys Met Asn
785                 790                 795                 800 
Val Val Ser Cys Ser Ser Leu Thr Ser Ser Leu Asn Tyr Phe Asp Tyr
                805                 810                 815     
His Gln Gln Thr Leu Pro Leu Gly Cys Arg Arg Ser Glu Ser Thr Phe
            820                 825                 830         
Leu Asn Val Glu Asn Gln Asn Thr Arg Asn Thr Ser Ala Asn His Ile
        835                 840                 845             
Tyr His His Ser Phe Asn Ser Gln Gly Pro Gln Gln Pro Asp Leu Ile
    850                 855                 860                 
Ile Asn Gly Val Pro Leu Pro Glu Thr Glu Asn Tyr Ser Phe Asp Ser
865                 870                 875                 880 
Asn Tyr Val Asn Ser Arg Ala His Leu Ile Lys Ser Ser Ser Thr Phe
                885                 890                 895     
Lys Asp Leu Glu Gly Asn Ser Leu Lys Asp Ser Gly His Glu Glu Ser
            900                 905                 910         
Asp Gln Thr Asp Ser Glu His Asp Val Gln Arg Ser Leu Tyr Cys Asp
        915                 920                 925             
Thr Ala Val Asn Asp Val Leu Asn Thr Ser Val Thr Ser Met Gly Ser
    930                 935                 940                 
Gln Met Pro Asp His Asp Gln Asn Glu Gly Phe His Cys Arg Glu Glu
945                 950                 955                 960 
Cys Arg Ile Leu Gly His Ser Asp Arg Cys Trp Met Pro Arg Asn Pro
                965                 970                 975     
Met Pro Ile Arg Ser Lys Ser Pro Glu His Val Arg Asn Ile Ile Ala
            980                 985                 990         
Leu Ser Ile Glu Ala Thr Ala Ala Asp Val Glu Ala Tyr Asp Asp Cys
        995                 1000                1005            
Gly Pro Thr Lys Arg Thr Phe Ala Thr Phe Gly Lys Asp Val Ser Asp
    1010                1015                1020                
His Pro Ala Glu Glu Arg Pro Thr Leu Lys Gly Lys Arg Thr Val Asp
1025                1030                1035                1040
Val Thr Ile Cys Ser Pro Lys Val Asn Ser Val Ile Arg Glu Ala Gly
                1045                1050                1055    
Asn Gly Cys Glu Ala Ile Ser Pro Val Thr Ser Pro Leu His Leu Lys
            1060                1065                1070        
Ser Ser Leu Pro Thr Lys Pro Ser Val Ser Tyr Thr Ile Ala Leu Ala
        1075                1080                1085            
Pro Pro Ala Arg Asp Leu Glu Gln Tyr Val Asn Asn Val Asn Asn Gly
    1090                1095                1100                
Pro Thr Arg Pro Ser Glu Ala Glu Pro Arg Gly Ala Asp Ser Glu Lys
1105                1110                1115                1120
Val Met His Glu Val Ser Pro Ile Leu Lys Glu Gly Arg Asn Lys Glu
                1125                1130                1135    
Ser Pro Gly Val Lys Arg Leu Lys Asp Ile Val Leu
            1140                1145            


<210> 5796
<211> 144
<212> PRT
<213> Homo sapiens

<400> 5796
Met Thr Arg Met Thr Arg Pro Leu Lys Ser His Val Gln Val Val Pro
 1               5                  10                  15      
Ser Thr Leu Met Trp Gln Ser Gln Ala Arg Thr Gln Pro Ala Pro Leu
            20                  25                  30          
Cys Cys Lys Leu Leu Thr Pro Arg Trp Leu Pro Leu Leu Leu Pro Thr
        35                  40                  45              
His Pro His Ser His Cys Leu Ala Gly His Leu Phe Phe Pro Ala Arg
    50                  55                  60                  
Tyr Ser Cys Ser Ser Glu Trp Lys Gln Gln Leu Thr Cys His Leu Cys
65                  70                  75                  80  
Val Thr Asp Ser Ala Pro Pro Arg His Thr Gly Val Val Val Ser Glu
                85                  90                  95      
His Leu Arg Arg Thr Glu Lys Leu Phe Phe Thr Ile Leu Ser Pro Asn
            100                 105                 110         
Gln Ser Lys Pro Phe Thr Thr Trp Lys Met Leu Lys Ala Thr Ile Pro
        115                 120                 125             
Ile Phe Val Cys Phe Leu Leu Asn Leu Ala Gln Lys Lys Lys Lys Lys
    130                 135                 140                 


<210> 5797
<211> 460
<212> PRT
<213> Homo sapiens

<400> 5797
Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser
 1               5                  10                  15      
Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu
            20                  25                  30          
Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn
        35                  40                  45              
Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr
    50                  55                  60                  
Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln
65                  70                  75                  80  
Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu
                85                  90                  95      
Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu
            100                 105                 110         
Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu
        115                 120                 125             
Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln
    130                 135                 140                 
Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu
145                 150                 155                 160 
Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys
                165                 170                 175     
Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln
            180                 185                 190         
His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile
        195                 200                 205             
Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg
    210                 215                 220                 
Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp
225                 230                 235                 240 
Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr
                245                 250                 255     
Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val
            260                 265                 270         
Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg
        275                 280                 285             
Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr
    290                 295                 300                 
Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile
305                 310                 315                 320 
Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu
                325                 330                 335     
Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly
            340                 345                 350         
Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn
        355                 360                 365             
Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp
    370                 375                 380                 
Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly
385                 390                 395                 400 
Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys
                405                 410                 415     
Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu
            420                 425                 430         
Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys
        435                 440                 445             
Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu
    450                 455                 460 


<210> 5798
<211> 509
<212> PRT
<213> Homo sapiens

<400> 5798
Ala Gly Ala Gly Arg Ala Leu Leu Gly Ala Arg Leu Arg Arg Glu Gly
 1               5                  10                  15      
Gly Ala Gly Ala Thr Leu Ala Arg Thr Glu Glu Thr Met Pro Gln Thr
            20                  25                  30          
Ser Val Val Phe Ser Ser Ile Leu Gly Pro Ser Cys Ser Gly Gln Val
        35                  40                  45              
Gln Pro Gly Met Gly Glu Arg Gly Gly Gly Ala Gly Gly Gly Ser Gly
    50                  55                  60                  
Asp Leu Ile Phe Gln Asp Gly His Leu Ile Ser Gly Ser Leu Glu Ala
65                  70                  75                  80  
Leu Met Glu His Leu Val Pro Thr Val Asp Tyr Tyr Pro Asp Arg Thr
                85                  90                  95      
Tyr Ile Phe Thr Phe Leu Leu Ser Ser Arg Val Phe Met Pro Pro His
            100                 105                 110         
Asp Leu Leu Ala Arg Val Gly Gln Ile Cys Val Glu Gln Lys Gln Gln
        115                 120                 125             
Leu Glu Ala Gly Pro Glu Lys Ala Lys Leu Lys Ser Phe Ser Ala Lys
    130                 135                 140                 
Ile Val Gln Leu Leu Lys Glu Trp Thr Glu Ala Phe Pro Tyr Asp Phe
145                 150                 155                 160 
Gln Asp Glu Lys Ala Met Ala Glu Leu Lys Ala Ile Thr His Arg Val
                165                 170                 175     
Thr Gln Cys Asp Glu Glu Asn Gly Thr Val Lys Lys Ala Ile Ala Gln
            180                 185                 190         
Met Thr Gln Ser Leu Leu Leu Ser Leu Ala Ala Arg Ser Gln Leu Gln
        195                 200                 205             
Glu Leu Arg Glu Lys Leu Arg Pro Pro Ala Val Asp Lys Gly Pro Ile
    210                 215                 220                 
Leu Lys Thr Lys Pro Pro Ala Ala Gln Lys Asp Ile Leu Gly Val Cys
225                 230                 235                 240 
Cys Asp Pro Leu Val Leu Ala Gln Gln Leu Thr His Ile Glu Leu Asp
                245                 250                 255     
Arg Val Ser Ser Ile Tyr Pro Glu Asp Leu Met Gln Ile Val Ser His
            260                 265                 270         
Met Asp Ser Leu Asp Asn His Arg Cys Arg Gly Asp Leu Thr Lys Thr
        275                 280                 285             
Tyr Ser Leu Glu Ala Tyr Asp Asn Trp Phe Asn Cys Leu Ser Met Leu
    290                 295                 300                 
Val Ala Thr Glu Val Cys Arg Val Val Lys Lys Lys His Arg Thr Arg
305                 310                 315                 320 
Met Leu Glu Phe Phe Ile Asp Val Ala Arg Glu Cys Phe Asn Ile Gly
                325                 330                 335     
Asn Phe Asn Ser Met Met Ala Ile Ile Ser Gly Met Asn Leu Ser Pro
            340                 345                 350         
Val Ala Arg Leu Lys Lys Thr Trp Ser Lys Val Lys Thr Ala Lys Phe
        355                 360                 365             
Asp Val Leu Glu His His Met Asp Pro Ser Ser Asn Phe Cys Asn Tyr
    370                 375                 380                 
Arg Thr Ala Leu Gln Gly Ala Thr Gln Arg Ser Gln Met Ala Asn Ser
385                 390                 395                 400 
Ser Arg Glu Lys Ile Val Ile Pro Val Phe Asn Leu Phe Val Lys Asp
                405                 410                 415     
Ile Tyr Phe Leu His Lys Ile His Thr Asn His Leu Pro Asn Gly His
            420                 425                 430         
Ile Asn Phe Lys Lys Phe Trp Glu Ile Ser Arg Gln Ile His Glu Phe
        435                 440                 445             
Met Thr Trp Thr Gln Val Glu Cys Pro Phe Glu Lys Asp Lys Lys Ile
    450                 455                 460                 
Gln Ser Tyr Leu Leu Thr Ala Pro Ile Tyr Ser Glu Glu Ala Leu Phe
465                 470                 475                 480 
Val Ala Ser Phe Glu Ser Glu Gly Pro Glu Asn His Met Glu Lys Asp
                485                 490                 495     
Ser Trp Lys Thr Leu Arg Thr Thr Leu Leu Asn Arg Ala
            500                 505                 


<210> 5799
<211> 519
<212> PRT
<213> Homo sapiens

<400> 5799
Glu Trp Val Leu Ala Trp Leu Ala Gly Arg Gly Ala Ala Ala Arg Trp
 1               5                  10                  15      
Thr Pro Asp Arg Ala Gly Arg Arg Gly Glu Pro Ala Ala Arg Met Phe
            20                  25                  30          
Leu Glu Pro Gln Glu Thr Met Pro Gln Thr Ser Val Val Phe Ser Ser
        35                  40                  45              
Ile Leu Gly Pro Ser Cys Ser Gly Gln Val Gln Pro Gly Met Gly Glu
    50                  55                  60                  
Arg Gly Gly Gly Ala Gly Gly Gly Ser Gly Asp Leu Ile Phe Gln Asp
65                  70                  75                  80  
Gly His Leu Ile Ser Gly Ser Leu Glu Ala Leu Met Glu His Leu Val
                85                  90                  95      
Pro Thr Val Asp Tyr Tyr Pro Asp Arg Thr Tyr Ile Phe Thr Phe Leu
            100                 105                 110         
Leu Ser Ser Arg Val Phe Met Pro Pro His Asp Leu Leu Ala Arg Val
        115                 120                 125             
Gly Gln Ile Cys Val Glu Gln Lys Gln Gln Leu Glu Ala Gly Pro Glu
    130                 135                 140                 
Lys Ala Lys Leu Lys Ser Phe Ser Ala Lys Ile Val Gln Leu Leu Lys
145                 150                 155                 160 
Glu Trp Thr Glu Ala Phe Pro Tyr Asp Phe Gln Asp Glu Lys Ala Met
                165                 170                 175     
Ala Glu Leu Lys Ala Ile Thr His Arg Val Thr Gln Cys Asp Glu Glu
            180                 185                 190         
Asn Gly Thr Val Lys Lys Ala Ile Ala Gln Met Thr Gln Ser Leu Leu
        195                 200                 205             
Leu Ser Leu Ala Ala Arg Ser Gln Leu Gln Glu Leu Arg Glu Lys Leu
    210                 215                 220                 
Arg Pro Pro Ala Val Asp Lys Gly Pro Ile Leu Lys Thr Lys Pro Pro
225                 230                 235                 240 
Ala Ala Gln Lys Asp Ile Leu Gly Val Cys Cys Asp Pro Leu Val Leu
                245                 250                 255     
Ala Gln Gln Leu Thr His Ile Glu Leu Asp Arg Val Ser Ser Ile Tyr
            260                 265                 270         
Pro Glu Asp Leu Met Gln Ile Val Ser His Met Asp Ser Leu Asp Asn
        275                 280                 285             
His Arg Cys Arg Gly Asp Leu Thr Lys Thr Tyr Ser Leu Glu Ala Tyr
    290                 295                 300                 
Asp Asn Trp Phe Asn Cys Leu Ser Met Leu Val Ala Thr Glu Val Cys
305                 310                 315                 320 
Arg Val Val Lys Lys Lys His Arg Thr Arg Met Leu Glu Phe Phe Ile
                325                 330                 335     
Asp Val Ala Arg Glu Cys Phe Asn Ile Gly Asn Phe Asn Ser Met Met
            340                 345                 350         
Ala Ile Ile Ser Gly Met Asn Leu Ser Pro Val Ala Arg Leu Lys Lys
        355                 360                 365             
Thr Trp Ser Lys Val Lys Thr Ala Lys Phe Asp Val Leu Glu His His
    370                 375                 380                 
Met Asp Pro Ser Ser Asn Phe Cys Asn Tyr Arg Thr Ala Leu Gln Gly
385                 390                 395                 400 
Ala Thr Gln Arg Ser Gln Met Ala Asn Ser Ser Arg Glu Lys Ile Val
                405                 410                 415     
Ile Pro Val Phe Asn Leu Phe Val Lys Asp Ile Tyr Phe Leu His Lys
            420                 425                 430         
Ile His Thr Asn His Leu Pro Asn Gly His Ile Asn Phe Lys Lys Phe
        435                 440                 445             
Trp Glu Ile Ser Arg Gln Ile His Glu Phe Met Thr Trp Thr Gln Val
    450                 455                 460                 
Glu Cys Pro Phe Glu Lys Asp Lys Lys Ile Gln Ser Tyr Leu Leu Thr
465                 470                 475                 480 
Ala Pro Ile Tyr Ser Glu Glu Ala Leu Phe Val Ala Ser Phe Glu Ser
                485                 490                 495     
Glu Gly Pro Glu Asn His Met Glu Lys Asp Ser Trp Lys Thr Leu Arg
            500                 505                 510         
Thr Thr Leu Leu Asn Arg Ala
        515                 


<210> 5800
<211> 1061
<212> PRT
<213> Homo sapiens

<400> 5800
Pro Lys Met Ala Ala Val Ala Gly Ser Gly Ala Ala Ala Ala Pro Ser
 1               5                  10                  15      
Ser Leu Leu Leu Val Val Gly Ser Glu Phe Gly Ser Pro Gly Leu Leu
            20                  25                  30          
Thr Tyr Val Leu Glu Glu Leu Glu Arg Gly Ile Arg Ser Trp Asp Val
        35                  40                  45              
Asp Pro Gly Val Cys Asn Leu Asp Glu Gln Leu Lys Val Phe Val Ser
    50                  55                  60                  
Arg His Ser Ala Thr Phe Ser Ser Ile Val Lys Gly Gln Arg Ser Leu
65                  70                  75                  80  
His His Arg Gly Asp Asn Leu Glu Thr Leu Val Leu Leu Asn Pro Ser
                85                  90                  95      
Asp Lys Ser Leu Tyr Asp Glu Leu Arg Asn Leu Leu Leu Asp Pro Ala
            100                 105                 110         
Ser His Lys Leu Leu Val Leu Ala Gly Pro Cys Leu Glu Glu Thr Gly
        115                 120                 125             
Glu Leu Leu Leu Gln Thr Gly Gly Phe Ser Pro His His Phe Leu Gln
    130                 135                 140                 
Val Leu Lys Asp Arg Glu Ile Arg Asp Ile Leu Ala Thr Thr Pro Pro
145                 150                 155                 160 
Pro Val Gln Pro Pro Ile Leu Thr Ile Thr Cys Pro Thr Phe Gly Asp
                165                 170                 175     
Trp Ala Gln Leu Ala Pro Ala Val Pro Gly Leu Gln Gly Ala Leu Arg
            180                 185                 190         
Leu Gln Leu Arg Leu Asn Pro Pro Ala Gln Leu Pro Asn Ser Glu Gly
        195                 200                 205             
Leu Cys Glu Phe Leu Glu Tyr Val Ala Glu Ser Leu Glu Pro Pro Ser
    210                 215                 220                 
Pro Phe Glu Leu Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Arg Leu
225                 230                 235                 240 
Gly Arg Pro Cys Cys Tyr Ile Phe Pro Gly Gly Leu Gly Asp Ala Ala
                245                 250                 255     
Phe Phe Ala Val Asn Gly Phe Thr Val Leu Val Asn Gly Gly Ser Asn
            260                 265                 270         
Pro Lys Ser Ser Phe Trp Lys Leu Val Arg His Leu Asp Arg Val Asp
        275                 280                 285             
Ala Val Leu Val Thr His Pro Gly Ala Asp Ser Leu Pro Gly Leu Asn
    290                 295                 300                 
Ser Leu Leu Arg Arg Lys Leu Ala Glu Arg Ser Glu Val Ala Ala Gly
305                 310                 315                 320 
Gly Gly Ser Trp Asp Asp Arg Leu Arg Arg Leu Ile Ser Pro Asn Leu
                325                 330                 335     
Gly Val Val Phe Phe Asn Ala Cys Glu Ala Ala Ser Arg Leu Ala Arg
            340                 345                 350         
Gly Glu Asp Glu Ala Glu Leu Ala Leu Ser Leu Leu Ala Gln Leu Gly
        355                 360                 365             
Ile Thr Pro Leu Pro Leu Ser Arg Gly Pro Val Pro Ala Lys Pro Thr
    370                 375                 380                 
Val Leu Phe Glu Lys Met Gly Val Gly Arg Leu Asp Met Tyr Val Leu
385                 390                 395                 400 
His Pro Pro Ser Ala Gly Ala Glu Arg Thr Leu Ala Ser Val Cys Ala
                405                 410                 415     
Leu Leu Val Trp His Pro Ala Gly Pro Gly Glu Lys Val Val Arg Val
            420                 425                 430         
Leu Phe Pro Gly Cys Thr Pro Pro Ala Tyr Leu Leu Asp Gly Leu Val
        435                 440                 445             
Arg Leu Gln His Leu Arg Phe Leu Arg Glu Pro Val Val Thr Pro Gln
    450                 455                 460                 
Asp Leu Glu Gly Pro Gly Arg Ala Glu Ser Lys Glu Ser Val Gly Ser
465                 470                 475                 480 
Arg Asp Ser Ser Lys Arg Glu Gly Leu Leu Ala Thr His Pro Arg Pro
                485                 490                 495     
Gly Gln Glu Arg Pro Gly Val Ala Arg Lys Glu Pro Ala Arg Ala Glu
            500                 505                 510         
Ala Pro Arg Lys Thr Glu Lys Glu Ala Lys Thr Pro Arg Glu Leu Lys
        515                 520                 525             
Lys Asp Pro Lys Pro Ser Val Ser Arg Thr Gln Pro Arg Glu Val Arg
    530                 535                 540                 
Arg Ala Ala Ser Ser Val Pro Asn Leu Lys Lys Thr Asn Ala Gln Ala
545                 550                 555                 560 
Ala Pro Lys Pro Arg Lys Ala Pro Ser Thr Ser His Ser Gly Phe Pro
                565                 570                 575     
Pro Val Ala Asn Gly Pro Arg Ser Pro Pro Ser Leu Arg Cys Gly Glu
            580                 585                 590         
Ala Ser Pro Pro Ser Ala Ala Cys Gly Ser Pro Ala Ser Gln Leu Val
        595                 600                 605             
Ala Thr Pro Ser Leu Glu Leu Gly Pro Ile Pro Ala Gly Glu Glu Lys
    610                 615                 620                 
Ala Leu Glu Leu Pro Leu Ala Ala Ser Ser Ile Pro Arg Pro Arg Thr
625                 630                 635                 640 
Pro Ser Pro Glu Ser His Arg Ser Pro Ala Glu Gly Ser Glu Arg Leu
                645                 650                 655     
Ser Leu Ser Pro Leu Arg Gly Gly Glu Ala Gly Pro Asp Ala Ser Pro
            660                 665                 670         
Thr Val Thr Thr Pro Thr Val Thr Thr Pro Ser Leu Pro Ala Glu Val
        675                 680                 685             
Gly Ser Pro His Ser Thr Glu Val Asp Glu Ser Leu Ser Val Ser Phe
    690                 695                 700                 
Glu Gln Val Leu Pro Pro Ser Ala Pro Thr Ser Glu Ala Gly Leu Ser
705                 710                 715                 720 
Leu Pro Leu Arg Gly Pro Arg Ala Arg Arg Ser Ala Ser Pro His Asp
                725                 730                 735     
Val Asp Leu Cys Leu Val Ser Pro Cys Glu Phe Glu His Arg Lys Ala
            740                 745                 750         
Val Pro Met Ala Pro Ala Pro Ala Ser Pro Gly Ser Ser Asn Asp Ser
        755                 760                 765             
Ser Ala Arg Ser Gln Glu Arg Ala Gly Gly Leu Gly Ala Glu Glu Thr
    770                 775                 780                 
Pro Pro Thr Ser Val Ser Glu Ser Leu Pro Thr Leu Ser Asp Ser Asp
785                 790                 795                 800 
Pro Val Pro Leu Ala Pro Gly Ala Ala Asp Ser Asp Glu Asp Thr Glu
                805                 810                 815     
Gly Phe Gly Val Pro Arg His Asp Pro Leu Pro Asp Pro Leu Lys Val
            820                 825                 830         
Pro Pro Pro Leu Pro Asp Pro Ser Ser Ile Cys Met Val Asp Pro Glu
        835                 840                 845             
Met Leu Pro Pro Lys Thr Ala Arg Gln Thr Glu Asn Val Ser Arg Thr
    850                 855                 860                 
Arg Lys Pro Leu Ala Arg Pro Asn Ser Arg Ala Ala Ala Pro Lys Ala
865                 870                 875                 880 
Thr Pro Val Ala Ala Ala Lys Thr Lys Gly Leu Ala Gly Gly Asp Arg
                885                 890                 895     
Ala Ser Arg Pro Leu Ser Ala Arg Ser Glu Pro Ser Glu Lys Gly Gly
            900                 905                 910         
Arg Ala Pro Leu Ser Arg Lys Ser Ser Thr Pro Lys Thr Ala Thr Arg
        915                 920                 925             
Gly Pro Ser Gly Ser Ala Ser Ser Arg Pro Gly Val Ser Ala Thr Pro
    930                 935                 940                 
Pro Lys Ser Pro Val Tyr Leu Asp Leu Ala Tyr Leu Pro Ser Gly Ser
945                 950                 955                 960 
Ser Ala His Leu Val Asp Glu Glu Phe Phe Gln Arg Val Arg Ala Leu
                965                 970                 975     
Cys Tyr Val Ile Ser Gly Gln Asp Gln Arg Lys Glu Glu Gly Met Arg
            980                 985                 990         
Ala Val Leu Asp Ala Leu Leu Ala Ser Lys Gln His Trp Asp Arg Asp
        995                 1000                1005            
Leu Gln Val Thr Leu Ile Pro Thr Phe Asp Ser Val Ala Met His Thr
    1010                1015                1020                
Trp Tyr Ala Glu Thr His Ala Arg His Gln Ala Leu Gly Ile Thr Val
1025                1030                1035                1040
Leu Gly Ser Asn Ser Met Val Ser Met Gln Asp Asp Ala Phe Pro Ala
                1045                1050                1055    
Cys Lys Val Glu Phe
            1060    


<210> 5801
<211> 125
<212> PRT
<213> Homo sapiens

<400> 5801
Met His Pro Ala Arg Lys Leu Leu Ser Leu Leu Phe Leu Ile Leu Met
 1               5                  10                  15      
Gly Thr Glu Leu Thr Gln Val Leu Pro Thr Asn Pro Glu Glu Ser Trp
            20                  25                  30          
Gln Val Tyr Ser Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr
        35                  40                  45              
Val Val Ala Pro Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys
    50                  55                  60                  
Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile
65                  70                  75                  80  
Glu Val Leu Asp Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys
                85                  90                  95      
Met Glu Asn Gln Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val Glu
            100                 105                 110         
Glu Ser His Lys Gln His Leu Ala Arg Gln Phe Lys Gly
        115                 120                 125 


<210> 5802
<211> 153
<212> PRT
<213> Homo sapiens

<400> 5802
Met Ser Val Pro Leu Leu Lys Ile Gly Val Val Leu Ser Thr Met Ala
 1               5                  10                  15      
Met Ile Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu
            20                  25                  30          
Asn Thr Thr Arg Leu Ser Ala Ala Ser Gly Gly Thr Leu Asp Arg Ser
        35                  40                  45              
Thr Gly Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser
    50                  55                  60                  
Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro
65                  70                  75                  80  
Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln
                85                  90                  95      
Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp
            100                 105                 110         
Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln
        115                 120                 125             
Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys
    130                 135                 140                 
Gln His Leu Ala Arg Gln Phe Lys Gly
145                 150             


<210> 5803
<211> 364
<212> PRT
<213> Homo sapiens

<400> 5803
Met Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln
 1               5                  10                  15      
Ser Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys
            20                  25                  30          
Gly Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu
        35                  40                  45              
Leu Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro
    50                  55                  60                  
Arg Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg
65                  70                  75                  80  
Arg Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val
                85                  90                  95      
Gly Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys
            100                 105                 110         
Thr Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln
        115                 120                 125             
Pro Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala
    130                 135                 140                 
Ala Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg
145                 150                 155                 160 
Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp
                165                 170                 175     
Gly Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser
            180                 185                 190         
Leu Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met
        195                 200                 205             
Asp Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn
    210                 215                 220                 
Ser Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg
225                 230                 235                 240 
Glu Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr
                245                 250                 255     
Ile Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly
            260                 265                 270         
Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr
        275                 280                 285             
Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu
    290                 295                 300                 
Thr Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro
305                 310                 315                 320 
Leu Gln Glu Asp Ala Asp Ile Gln Val Gly Gly Val Arg Ala Gln Leu
                325                 330                 335     
Met His Ile Ser Trp Trp Ser Arg Pro Gly Leu Gly Glu Arg Asp Leu
            340                 345                 350         
Cys Ala Arg Gly Arg Trp Pro Gly Gly Ser Ser Asp
        355                 360                 


<210> 5804
<211> 3396
<212> PRT
<213> Homo sapiens

<400> 5804
Met Thr Ala Trp Leu Ile Ser Leu Met Ser Ile Glu Val Leu Leu Leu
 1               5                  10                  15      
Ala Val Arg His Leu Ser Leu His Ile Glu Pro Glu Glu Gly Ser Leu
            20                  25                  30          
Ala Gly Gly Thr Trp Ile Thr Val Ile Phe Asp Gly Leu Glu Leu Gly
        35                  40                  45              
Val Leu Tyr Pro Asn Asn Gly Ser Gln Leu Glu Ile His Leu Val Asn
    50                  55                  60                  
Val Asn Met Val Val Pro Ala Leu Arg Ser Val Pro Cys Asp Val Phe
65                  70                  75                  80  
Pro Val Phe Leu Asp Leu Pro Val Val Thr Cys Arg Thr Arg Ser Val
                85                  90                  95      
Leu Ser Glu Ala His Glu Gly Leu Tyr Phe Leu Glu Ala Tyr Phe Gly
            100                 105                 110         
Gly Gln Leu Val Ser Ser Pro Asn Pro Gly Pro Arg Asp Ser Cys Thr
        115                 120                 125             
Phe Lys Phe Ser Lys Ala Gln Thr Pro Ile Val His Gln Val Tyr Pro
    130                 135                 140                 
Pro Ser Gly Val Pro Gly Lys Leu Ile His Val Tyr Gly Trp Ile Ile
145                 150                 155                 160 
Thr Gly Arg Leu Glu Thr Phe Asp Phe Asp Ala Glu Tyr Ile Asp Ser
                165                 170                 175     
Pro Val Ile Leu Glu Ala Gln Gly Asp Lys Trp Val Thr Pro Cys Ser
            180                 185                 190         
Leu Ile Asn Arg Gln Met Gly Ser Cys Tyr Pro Ile Gln Glu Asp His
        195                 200                 205             
Gly Leu Gly Thr Leu Gln Cys His Val Glu Gly Asp Tyr Ile Gly Ser
    210                 215                 220                 
Gln Asn Val Ser Phe Ser Val Phe Asn Lys Gly Lys Ser Met Val His
225                 230                 235                 240 
Lys Lys Ala Trp Leu Ile Ser Ala Lys Gln Asp Leu Phe Leu Tyr Gln
                245                 250                 255     
Thr His Ser Glu Ile Leu Ser Val Phe Pro Glu Thr Gly Ser Leu Gly
            260                 265                 270         
Gly Arg Thr Asn Ile Thr Ile Thr Gly Asp Phe Phe Asp Asn Ser Ala
        275                 280                 285             
Gln Val Thr Ile Ala Gly Ile Pro Cys Asp Ile Arg His Val Ser Pro
    290                 295                 300                 
Arg Lys Ile Glu Cys Thr Thr Arg Ala Pro Gly Lys Asp Val Arg Leu
305                 310                 315                 320 
Thr Thr Pro Gln Pro Gly Asn Arg Gly Leu Leu Phe Glu Val Gly Asp
                325                 330                 335     
Ala Val Glu Gly Leu Glu Leu Thr Glu Ala Thr Pro Gly Tyr Arg Trp
            340                 345                 350         
Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser Gln Glu
        355                 360                 365             
Gly Gln Pro Phe Arg Ala Arg Leu Ser Gly Phe Phe Val Ala Pro Glu
    370                 375                 380                 
Thr Asn Asn Tyr Thr Phe Trp Ile Gln Ala Asp Ser Gln Ala Ser Leu
385                 390                 395                 400 
His Phe Ser Trp Ser Glu Glu Pro Arg Thr Lys Val Lys Val Ala Ser
                405                 410                 415     
Ile Ser Val Gly Thr Ala Asp Trp Phe Asp Ser Trp Glu Gln Asn Arg
            420                 425                 430         
Asp Glu Gly Thr Trp Gln Gln Lys Thr Pro Lys Leu Glu Leu Leu Gly
        435                 440                 445             
Gly Ala Met Tyr Tyr Leu Glu Ala Glu His His Gly Ile Ala Pro Ser
    450                 455                 460                 
Arg Gly Met Arg Ile Gly Val Gln Ile His Asn Thr Trp Leu Asn Pro
465                 470                 475                 480 
Asp Val Val Thr Thr Tyr Leu Arg Glu Lys His Gln Ile Arg Val Arg
                485                 490                 495     
Ala Gln Arg Leu Pro Glu Val Gln Val Leu Asn Val Ser Gly Arg Gly
            500                 505                 510         
Asn Phe Phe Leu Thr Trp Asp Asn Val Ser Ser Gln Pro Ile Pro Ala
        515                 520                 525             
Asn Ala Thr Ala His Leu Ile Gln Thr Thr Ile Glu Glu Leu Leu Ala
    530                 535                 540                 
Val Lys Cys Lys Leu Glu Pro Leu Trp Ser Asn Ile Leu Leu Arg Leu
545                 550                 555                 560 
Gly Phe Glu Arg Gly Pro Glu Val Ser Asn Ser Asp Gly Asp Leu Thr
                565                 570                 575     
Ser Gly Thr Glu Pro Phe Cys Gly Arg Phe Ser Leu Arg Gln Pro Arg
            580                 585                 590         
His Leu Val Leu Thr Pro Pro Ala Ala Gln Lys Gly Tyr Arg Leu Asp
        595                 600                 605             
Gln Tyr Thr His Leu Cys Leu Ala Tyr Lys Gly His Met Asn Lys Ile
    610                 615                 620                 
Leu Lys Met Ile Val Ser Phe Thr Ile Gly Phe Gln Asn Met Val Lys
625                 630                 635                 640 
Asn Thr Thr Cys Asp Trp Ser Leu Thr Arg Thr Ser Pro Glu Ser Trp
                645                 650                 655     
Gln Phe Asp Cys Thr Asp Leu Trp Glu Thr Cys Val Arg Cys Phe Gly
            660                 665                 670         
Asp Leu Gln Pro Pro Pro Ala Asn Ser Pro Val Leu Val His Gln Ile
        675                 680                 685             
Asn Leu Leu Pro Leu Ala Gln Glu Thr Gly Leu Phe Tyr Val Asp Glu
    690                 695                 700                 
Ile Ile Ile Ala Asp Thr Asn Val Thr Val Ser Gln Ala Asp Ser Gly
705                 710                 715                 720 
Thr Ala Arg Pro Gly Gly Asn Leu Val Glu Ser Val Ser Val Val Gly
                725                 730                 735     
Ser Pro Pro Val Tyr Ser Val Thr Ser Trp Leu Ala Gly Cys Gly Thr
            740                 745                 750         
Glu Leu Pro Leu Ile Thr Ala Arg Ser Val Pro Thr Glu Gly Thr Glu
        755                 760                 765             
Glu Gly Ser Gly Leu Val Leu Val Thr Thr Gln Arg Arg Gln Arg Thr
    770                 775                 780                 
Ser Pro Pro Leu Gly Gly His Phe Arg Ile Gln Leu Pro Asn Thr Val
785                 790                 795                 800 
Ile Ser Asp Val Pro Val Gln Ile Ser Ala His His Leu His Gln Leu
                805                 810                 815     
Leu Gln Asn Asn Ala Asp Asp Phe Thr Ser Arg Tyr Leu Asn Ala Ser
            820                 825                 830         
Asp Phe Thr Val Lys Glu Asp Leu Tyr Thr Cys Tyr Glu His Val Trp
        835                 840                 845             
Thr Leu Ser Trp Ser Thr Gln Ile Gly Asp Leu Pro Asn Phe Ile Arg
    850                 855                 860                 
Val Ser Asp Glu Asn Leu Thr Gly Val Asn Pro Ala Ala Ala Thr Arg
865                 870                 875                 880 
Val Val Tyr Asp Gly Gly Val Phe Leu Gly Pro Ile Phe Gly Asp Met
                885                 890                 895     
Leu Ala Thr Ala Asn Gln His Thr Gln Val Val Val Arg Val Asn Asp
            900                 905                 910         
Val Pro Ala His Cys Pro Gly Ser Cys Ser Phe Gln Tyr Leu Gln Gly
        915                 920                 925             
Ser Thr Pro Cys Val His Ser Val Trp Tyr Ser Ile Asp Gly Asp Ile
    930                 935                 940                 
Asn Leu Met Ile Tyr Ile Thr Gly Thr Gly Phe Ser Gly Asp Ser Gln
945                 950                 955                 960 
Phe Leu Gln Val Thr Val Asn Lys Thr Ser Cys Lys Val Ile Phe Ser
                965                 970                 975     
Asn Gln Thr Asn Val Val Cys Gln Thr Asp Leu Leu Pro Val Gly Met
            980                 985                 990         
His Arg Ile Leu Met Leu Val Arg Pro Ser Gly Leu Ala Ile Ser Ala
        995                 1000                1005            
Thr Gly Glu Asp Leu Phe Leu Asn Val Lys Pro Arg Leu Asp Met Val
    1010                1015                1020                
Glu Pro Ser Arg Ala Ala Asp Ile Gly Gly Leu Trp Ala Thr Ile Arg
1025                1030                1035                1040
Gly Ser Ser Leu Glu Gly Val Ser Leu Ile Leu Phe Gly Ser Tyr Ser
                1045                1050                1055    
Cys Ala Ile Asn Val Ala Thr Ser Asn Ser Ser Arg Ile Gln Cys Lys
            1060                1065                1070        
Val Pro Pro Arg Gly Lys Asp Gly Arg Ile Val Asn Val Thr Val Ile
        1075                1080                1085            
Arg Gly Asp Tyr Ser Ala Val Leu Pro Arg Ala Phe Thr Tyr Val Ser
    1090                1095                1100                
Ser Leu Asn Pro Val Ile Val Thr Leu Ser Arg Asn Ile Ser Asn Ile
1105                1110                1115                1120
Ala Gly Gly Glu Thr Leu Val Ile Gly Val Ala Arg Leu Met Asn Tyr
                1125                1130                1135    
Thr Asp Leu Asp Val Glu Val His Val Gln Asp Ala Leu Ala Pro Val
            1140                1145                1150        
His Thr Gln Ser Ala Trp Gly Leu Glu Val Ala Leu Pro Pro Leu Pro
        1155                1160                1165            
Ala Gly Leu His Arg Ile Ser Val Ser Ile Asn Gly Val Ser Ile His
    1170                1175                1180                
Ser Gln Gly Val Asp Leu His Ile Gln Tyr Leu Thr Glu Val Phe Ser
1185                1190                1195                1200
Ile Glu Pro Cys Cys Gly Ser Leu Leu Gly Gly Thr Ile Leu Ser Ile
                1205                1210                1215    
Ser Gly Ile Gly Phe Ser Arg Asp Pro Ala Leu Val Trp Val Leu Val
            1220                1225                1230        
Gly Asn Arg Ser Cys Asp Ile Val Asn Leu Thr Glu Ala Ser Ile Trp
        1235                1240                1245            
Cys Glu Thr Leu Pro Ala Pro Gln Ile Pro Asp Ala Gly Ala Pro Thr
    1250                1255                1260                
Val Pro Ala Ala Val Glu Val Trp Ala Gly Asn Arg Phe Phe Ala Arg
1265                1270                1275                1280
Gly Pro Ser Pro Ser Leu Val Gly Lys Gly Phe Thr Phe Met Tyr Glu
                1285                1290                1295    
Ala Ala Ala Thr Pro Val Val Thr Ala Met Gln Gly Glu Ile Thr Asn
            1300                1305                1310        
Ser Ser Leu Ser Leu His Val Gly Gly Ser Asn Leu Ser Asn Ser Val
        1315                1320                1325            
Ile Leu Leu Gly Asn Leu Asn Cys Asp Val Glu Thr Gln Ser Phe Gln
    1330                1335                1340                
Gly Asn Val Ser Leu Ser Gly Cys Ser Ile Pro Leu His Ser Leu Glu
1345                1350                1355                1360
Ala Gly Ile Tyr Pro Leu Gln Val Arg Gln Lys Gln Met Gly Phe Ala
                1365                1370                1375    
Asn Met Ser Val Val Leu Gln Gln Phe Ala Val Met Pro Arg Ile Met
            1380                1385                1390        
Ala Ile Phe Pro Ser Gln Gly Ser Ala Cys Gly Gly Thr Ile Leu Thr
        1395                1400                1405            
Val Arg Gly Leu Leu Leu Asn Ser Arg Arg Arg Ser Val Arg Val Asp
    1410                1415                1420                
Leu Ser Gly Pro Phe Thr Cys Val Ile Leu Ser Leu Gly Asp His Thr
1425                1430                1435                1440
Ile Leu Cys Gln Val Ser Leu Glu Gly Asp Pro Leu Pro Gly Ala Ser
                1445                1450                1455    
Phe Ser Leu Asn Val Thr Val Leu Val Asn Gly Leu Thr Ser Glu Cys
            1460                1465                1470        
Gln Gly Asn Cys Thr Leu Phe Ile Arg Glu Glu Ala Ser Pro Val Met
        1475                1480                1485            
Asp Ala Leu Ser Thr Asn Thr Ser Gly Ser Leu Thr Thr Val Leu Ile
    1490                1495                1500                
Arg Gly Gln Arg Leu Ala Thr Thr Ala Asp Glu Pro Met Val Phe Val
1505                1510                1515                1520
Asp Asp Gln Leu Pro Cys Asn Val Thr Phe Phe Asn Ala Ser His Val
                1525                1530                1535    
Val Cys Gln Thr Arg Asp Leu Ala Pro Gly Pro His Tyr Leu Ser Val
            1540                1545                1550        
Phe Tyr Thr Arg Asn Gly Tyr Ala Cys Ser Gly Asn Val Ser Arg His
        1555                1560                1565            
Phe Tyr Ile Met Pro Gln Val Phe His Tyr Phe Pro Lys Asn Phe Ser
    1570                1575                1580                
Leu His Gly Gly Ser Leu Leu Thr Ile Glu Gly Thr Gly Leu Arg Gly
1585                1590                1595                1600
Gln Asn Thr Thr Ser Val Tyr Ile Asp Gln Gln Thr Cys Leu Thr Val
                1605                1610                1615    
Asn Ile Gly Ala Glu Leu Ile Arg Cys Ile Val Pro Thr Gly Asn Gly
            1620                1625                1630        
Ser Val Ala Leu Glu Ile Glu Val Asp Gly Leu Trp Tyr His Ile Gly
        1635                1640                1645            
Val Ile Gly Tyr Asn Lys Ala Phe Thr Pro Glu Leu Ile Ser Ile Ser
    1650                1655                1660                
Gln Ser Asp Asp Ile Leu Thr Phe Ala Val Ala Gln Ile Ser Gly Ala
1665                1670                1675                1680
Ala Asn Ile Asp Ile Phe Ile Gly Met Ser Pro Cys Val Gly Val Ser
                1685                1690                1695    
Gly Asn His Thr Val Leu Gln Cys Val Val Pro Ser Leu Pro Ala Gly
            1700                1705                1710        
Glu Tyr His Val Arg Gly Tyr Asp Cys Ile Arg Gly Trp Ala Ser Ser
        1715                1720                1725            
Ala Leu Val Phe Thr Ser Arg Val Ile Ile Thr Ala Val Thr Glu Asn
    1730                1735                1740                
Phe Gly Cys Leu Gly Gly Arg Leu Val His Val Phe Gly Ala Gly Phe
1745                1750                1755                1760
Ser Pro Gly Asn Val Ser Ala Ala Val Cys Gly Ala Pro Cys Arg Val
                1765                1770                1775    
Leu Ala Asn Ala Thr Val Ser Ala Phe Ser Cys Leu Val Leu Pro Leu
            1780                1785                1790        
Asp Val Ser Leu Ala Phe Leu Cys Gly Leu Lys Arg Glu Glu Asp Ser
        1795                1800                1805            
Cys Glu Ala Ala Arg His Thr Tyr Val Gln Cys Asp Leu Thr Val Ala
    1810                1815                1820                
Met Ala Thr Glu Gln Leu Leu Glu Ser Trp Pro Tyr Leu Tyr Ile Cys
1825                1830                1835                1840
Glu Glu Ser Ser Gln Cys Leu Phe Val Pro Asp His Trp Ala Glu Ser
                1845                1850                1855    
Met Phe Pro Ser Phe Ser Gly Leu Phe Ile Ser Pro Lys Leu Glu Arg
            1860                1865                1870        
Asp Glu Val Leu Ile Tyr Asn Ser Ser Cys Asn Ile Thr Met Glu Thr
        1875                1880                1885            
Glu Ala Glu Met Glu Cys Glu Thr Pro Asn Gln Pro Ile Thr Val Lys
    1890                1895                1900                
Ile Thr Glu Ile Arg Lys Arg Trp Gly Gln Asn Thr Gln Gly Asn Phe
1905                1910                1915                1920
Ser Leu Gln Phe Cys Arg Arg Trp Ser Arg Thr His Ser Trp Phe Pro
                1925                1930                1935    
Glu Arg Leu Pro Gln Asp Gly Asp Asn Val Thr Val Glu Asn Gly Gln
            1940                1945                1950        
Leu Leu Leu Leu Asp Thr Asn Thr Ser Ile Leu Asn Leu Leu His Ile
        1955                1960                1965            
Lys Gly Gly Lys Leu Ile Phe Met Ala Pro Gly Pro Ile Glu Leu Arg
    1970                1975                1980                
Ala His Ala Ile Leu Val Ser Asp Gly Gly Glu Leu Arg Ile Gly Ser
1985                1990                1995                2000
Glu Asp Lys Pro Phe Gln Gly Arg Ala Gln Ile Thr Leu Tyr Gly Ser
                2005                2010                2015    
Ser Tyr Ser Thr Pro Phe Phe Pro Tyr Gly Val Lys Phe Leu Ala Val
            2020                2025                2030        
Arg Asn Gly Thr Leu Ser Leu His Gly Ser Leu Pro Glu Val Ile Val
        2035                2040                2045            
Thr Cys Leu Arg Ala Thr Ala His Ala Leu Asp Thr Val Leu Ala Leu
    2050                2055                2060                
Glu Asp Ala Val Asp Trp Asn Pro Gly Asp Glu Val Val Ile Ile Ser
2065                2070                2075                2080
Gly Thr Gly Val Lys Gly Ala Lys Pro Met Glu Glu Ile Val Thr Val
                2085                2090                2095    
Glu Thr Val Gln Asp Thr Asp Leu Tyr Leu Lys Ser Pro Leu Arg Tyr
            2100                2105                2110        
Ser His Asn Phe Thr Glu Asn Trp Val Ala Gly Glu His His Ile Leu
        2115                2120                2125            
Lys Ala Thr Val Ala Leu Leu Ser Arg Ser Ile Thr Ile Gln Gly Asn
    2130                2135                2140                
Leu Thr Asn Glu Arg Glu Lys Leu Leu Val Ser Cys Gln Glu Ala Asn
2145                2150                2155                2160
Ala Pro Glu Gly Asn Leu Gln His Cys Leu Tyr Ser Met Ser Glu Lys
                2165                2170                2175    
Met Leu Gly Ser Arg Asp Met Gly Ala Arg Val Ile Val Gln Ser Phe
            2180                2185                2190        
Pro Glu Glu Pro Ser Gln Val Gln Leu Lys Gly Val Gln Phe Gln Val
        2195                2200                2205            
Leu Gly Gln Ala Phe His Lys His Leu Ser Ser Leu Thr Leu Val Gly
    2210                2215                2220                
Ala Met Arg Glu Ser Phe Ile Gln Gly Cys Thr Val Arg Asn Ser Phe
2225                2230                2235                2240
Ser Arg Gly Leu Ser Met Cys Gly Thr Leu Gly Leu Lys Val Asp Ser
                2245                2250                2255    
Asn Val Phe Tyr Asn Ile Leu Gly His Ala Leu Leu Val Gly Thr Cys
            2260                2265                2270        
Thr Glu Met Arg Tyr Ile Ser Trp Glu Ala Ile His Gly Arg Lys Asp
        2275                2280                2285            
Asp Trp Ser Gly His Gly Asn Ile Ile Arg Asn Asn Val Ile Ile Gln
    2290                2295                2300                
Val Ser Gly Ala Glu Gly Leu Ser Asn Pro Glu Met Leu Thr Pro Ser
2305                2310                2315                2320
Gly Ile Tyr Ile Cys Ser Pro Thr Asn Val Ile Glu Gly Asn Arg Val
                2325                2330                2335    
Cys Gly Ala Gly Tyr Gly Tyr Phe Phe His Leu Met Thr Asn Gln Thr
            2340                2345                2350        
Ser Gln Ala Pro Leu Leu Ser Phe Thr Gln Asn Ile Ala His Ser Cys
        2355                2360                2365            
Thr Arg Tyr Gly Leu Phe Val Tyr Pro Lys Phe Gln Pro Pro Trp Asp
    2370                2375                2380                
Asn Val Thr Gly Thr Thr Leu Phe Gln Ser Phe Thr Val Trp Glu Ser
2385                2390                2395                2400
Ala Gly Gly Ala Gln Ile Phe Arg Ser Ser Asn Leu Arg Leu Lys Asn
                2405                2410                2415    
Phe Lys Val Tyr Ser Cys Arg Asp Phe Gly Ile Asp Val Leu Glu Ser
            2420                2425                2430        
Asp Ala Asn Thr Ser Val Thr Asp Ser Leu Leu Leu Gly His Phe Ala
        2435                2440                2445            
His Lys Gly Ser Leu Cys Met Ser Ser Gly Ile Lys Thr Pro Lys Arg
    2450                2455                2460                
Trp Glu Leu Met Val Ser Asn Thr Thr Phe Val Asn Phe Asp Leu Ile
2465                2470                2475                2480
Asn Cys Val Ala Ile Arg Thr Cys Ser Asp Cys Ser Gln Gly Gln Gly
                2485                2490                2495    
Gly Phe Thr Val Lys Thr Ser Gln Leu Lys Phe Thr Asn Ser Ser Asn
            2500                2505                2510        
Leu Val Ala Phe Pro Phe Pro His Ala Ala Ile Leu Glu Asp Leu Asp
        2515                2520                2525            
Gly Ser Leu Ser Gly Lys Asn Arg Ser His Ile Leu Ala Ser Met Glu
    2530                2535                2540                
Thr Leu Ser Ala Ser Cys Leu Val Asn Ser Ser Phe Gly Arg Val Val
2545                2550                2555                2560
His Gly Ser Ala Cys Gly Gly Gly Val Leu Phe His Arg Met Ser Ile
                2565                2570                2575    
Gly Leu Ala Asn Thr Pro Glu Val Ser Tyr Asp Leu Thr Met Thr Asp
            2580                2585                2590        
Ser Arg Asn Lys Thr Thr Thr Val Asn Tyr Val Arg Asp Thr Leu Ser
        2595                2600                2605            
Asn Pro Arg Gly Trp Met Ala Leu Leu Leu Asp Gln Glu Thr Tyr Ser
    2610                2615                2620                
Leu Gln Ser Glu Asn Leu Trp Ile Asn Arg Ser Leu Gln Tyr Ser Ala
2625                2630                2635                2640
Thr Phe Asp Asn Phe Ala Pro Gly Asn Tyr Leu Leu Leu Val His Thr
                2645                2650                2655    
Asp Leu Pro Pro Tyr Pro Asp Ile Leu Leu Arg Cys Gly Ser Arg Val
            2660                2665                2670        
Gly Leu Ser Phe Pro Phe Leu Pro Ser Pro Gly Gln Asn Gln Gly Cys
        2675                2680                2685            
Asp Trp Phe Phe Asn Ser Gln Leu Arg Gln Leu Thr Tyr Leu Val Ser
    2690                2695                2700                
Gly Glu Gly Gln Val Gln Val Ile Leu Arg Val Lys Glu Gly Met Pro
2705                2710                2715                2720
Pro Thr Ile Ser Ala Ser Thr Ser Ala Pro Glu Ser Ala Leu Lys Trp
                2725                2730                2735    
Ser Leu Pro Glu Thr Trp Gln Gly Val Glu Glu Gly Trp Gly Gly Tyr
            2740                2745                2750        
Asn Asn Thr Ile Pro Gly Pro Gly Asp Asp Val Leu Ile Leu Pro Asn
        2755                2760                2765            
Arg Thr Val Leu Val Asp Thr Asp Leu Pro Phe Phe Lys Gly Leu Tyr
    2770                2775                2780                
Val Met Gly Thr Leu Asp Phe Pro Val Asp Arg Ser Asn Val Leu Ser
2785                2790                2795                2800
Val Ala Cys Met Val Ile Ala Gly Gly Glu Leu Lys Val Gly Thr Leu
                2805                2810                2815    
Glu Asn Pro Leu Glu Lys Glu Gln Lys Leu Leu Ile Leu Leu Arg Ala
            2820                2825                2830        
Ser Glu Gly Val Phe Cys Asp Arg Met Asn Gly Ile His Ile Asp Pro
        2835                2840                2845            
Gly Thr Ile Gly Val Tyr Gly Lys Val His Leu Tyr Ser Ala Tyr Pro
    2850                2855                2860                
Lys Asn Ser Trp Thr His Leu Gly Ala Asp Ile Ala Ser Gly Asn Glu
2865                2870                2875                2880
Arg Ile Ile Val Glu Asp Ala Val Asp Trp Arg Pro His Asp Lys Ile
                2885                2890                2895    
Val Leu Ser Ser Ser Ser Tyr Glu Pro His Glu Ala Glu Val Leu Thr
            2900                2905                2910        
Val Lys Glu Val Lys Gly His His Val Arg Ile Tyr Glu Arg Leu Lys
        2915                2920                2925            
His Arg His Ile Gly Ser Val His Val Thr Glu Asp Gly Arg His Ile
    2930                2935                2940                
Arg Leu Ala Ala Glu Val Gly Leu Leu Thr Arg Asn Ile Gln Ile Gln
2945                2950                2955                2960
Pro Asp Val Ser Cys Arg Gly Arg Leu Phe Val Gly Ser Phe Arg Lys
                2965                2970                2975    
Ser Ser Arg Glu Glu Phe Ser Gly Val Leu Gln Leu Leu Asn Val Glu
            2980                2985                2990        
Ile Gln Asn Phe Gly Ser Pro Leu Tyr Ser Ser Val Glu Phe Ser Asn
        2995                3000                3005            
Val Ser Ala Gly Ser Trp Ile Ile Ser Ser Thr Leu His Gln Ser Cys
    3010                3015                3020                
Gly Gly Gly Ile His Ala Ala Ala Ser His Gly Val Leu Leu Asn Asp
3025                3030                3035                3040
Asn Ile Val Phe Gly Thr Ala Gly His Gly Ile Asp Leu Glu Gly Gln
                3045                3050                3055    
Ala Tyr Thr Val Thr Asn Asn Leu Val Val Leu Met Thr Gln Pro Ala
            3060                3065                3070        
Trp Ser Thr Ile Trp Val Ala Gly Ile Lys Val Asn Gln Val Lys Asp
        3075                3080                3085            
Ile Asn Leu His Gly Asn Val Val Ala Gly Ser Glu Arg Leu Gly Phe
    3090                3095                3100                
His Ile Arg Gly His Lys Cys Ser Ser Cys Glu Leu Leu Trp Ser Asp
3105                3110                3115                3120
Asn Val Ala His Ser Ser Leu His Gly Leu His Leu Tyr Lys Glu Ser
                3125                3130                3135    
Gly Leu Asp Asn Cys Thr Arg Ile Ser Gly Phe Leu Ala Phe Lys Asn
            3140                3145                3150        
Phe Asp Tyr Gly Ala Met Leu His Val Glu Asn Ser Val Glu Ile Glu
        3155                3160                3165            
Asn Ile Thr Leu Val Asp Asn Thr Ile Gly Leu Leu Ala Val Val Tyr
    3170                3175                3180                
Val Phe Ser Ala Pro Gln Asn Ser Val Lys Lys Val Gln Ile Val Leu
3185                3190                3195                3200
Arg Asn Ser Val Ile Val Ala Thr Ser Ser Ser Phe Asp Cys Ile Gln
                3205                3210                3215    
Asp Lys Val Lys Pro His Ser Ala Asn Leu Thr Ser Thr Asp Arg Ala
            3220                3225                3230        
Pro Ser Asn Pro Arg Gly Gly Arg Ile Gly Ile Leu Trp Pro Val Phe
        3235                3240                3245            
Thr Ser Glu Pro Asn Gln Trp Pro Gln Glu Pro Trp His Lys Val Arg
    3250                3255                3260                
Asn Asp His Ser Ile Ser Gly Ile Met Lys Leu Gln Asp Val Thr Phe
3265                3270                3275                3280
Ser Ser Phe Val Lys Ser Cys Tyr Ser Asp Asp Leu Asp Val Cys Ile
                3285                3290                3295    
Leu Pro Asn Ala Glu Asn Ser Gly Ile Met His Pro Ile Thr Ala Glu
            3300                3305                3310        
Arg Thr Arg Met Leu Lys Ile Lys Asp Lys Asn Lys Phe Tyr Phe Pro
        3315                3320                3325            
Ser Leu Gln Pro Arg Lys Asp Leu Gly Lys Val Val Cys Pro Glu Leu
    3330                3335                3340                
Asp Cys Ala Ser Pro Arg Lys Tyr Leu Phe Lys Asp Leu Asp Gly Arg
3345                3350                3355                3360
Ala Leu Gly Leu Pro Pro Pro Val Ser Val Phe Pro Lys Thr Glu Ala
                3365                3370                3375    
Glu Trp Thr Ala Ser Phe Phe Asn Ala Val Thr Thr Glu Gln Ala Leu
            3380                3385                3390        
Lys Ile Ser Glu
        3395    


<210> 5805
<211> 4074
<212> PRT
<213> Homo sapiens

<400> 5805
Met Thr Ala Trp Leu Ile Ser Leu Met Ser Ile Glu Val Leu Leu Leu
 1               5                  10                  15      
Ala Val Arg His Leu Ser Leu His Ile Glu Pro Glu Glu Gly Ser Leu
            20                  25                  30          
Ala Gly Gly Thr Trp Ile Thr Val Ile Phe Asp Gly Leu Glu Leu Gly
        35                  40                  45              
Val Leu Tyr Pro Asn Asn Gly Ser Gln Leu Glu Ile His Leu Val Asn
    50                  55                  60                  
Val Asn Met Val Val Pro Ala Leu Arg Ser Val Pro Cys Asp Val Phe
65                  70                  75                  80  
Pro Val Phe Leu Asp Leu Pro Val Val Thr Cys Arg Thr Arg Ser Val
                85                  90                  95      
Leu Ser Glu Ala His Glu Gly Leu Tyr Phe Leu Glu Ala Tyr Phe Gly
            100                 105                 110         
Gly Gln Leu Val Ser Ser Pro Asn Pro Gly Pro Arg Asp Ser Cys Thr
        115                 120                 125             
Phe Lys Phe Ser Lys Ala Gln Thr Pro Ile Val His Gln Val Tyr Pro
    130                 135                 140                 
Pro Ser Gly Val Pro Gly Lys Leu Ile His Val Tyr Gly Trp Ile Ile
145                 150                 155                 160 
Thr Gly Arg Leu Glu Thr Phe Asp Phe Asp Ala Glu Tyr Ile Asp Ser
                165                 170                 175     
Pro Val Ile Leu Glu Ala Gln Gly Asp Lys Trp Val Thr Pro Cys Ser
            180                 185                 190         
Leu Ile Asn Arg Gln Met Gly Ser Cys Tyr Pro Ile Gln Glu Asp His
        195                 200                 205             
Gly Leu Gly Thr Leu Gln Cys His Val Glu Gly Asp Tyr Ile Gly Ser
    210                 215                 220                 
Gln Asn Val Ser Phe Ser Val Phe Asn Lys Gly Lys Ser Met Val His
225                 230                 235                 240 
Lys Lys Ala Trp Leu Ile Ser Ala Lys Gln Asp Leu Phe Leu Tyr Gln
                245                 250                 255     
Thr His Ser Glu Ile Leu Ser Val Phe Pro Glu Thr Gly Ser Leu Gly
            260                 265                 270         
Gly Arg Thr Asn Ile Thr Ile Thr Gly Asp Phe Phe Asp Asn Ser Ala
        275                 280                 285             
Gln Val Thr Ile Ala Gly Ile Pro Cys Asp Ile Arg His Val Ser Pro
    290                 295                 300                 
Arg Lys Ile Glu Cys Thr Thr Arg Ala Pro Gly Lys Asp Val Arg Leu
305                 310                 315                 320 
Thr Thr Pro Gln Pro Gly Asn Arg Gly Leu Leu Phe Glu Val Gly Asp
                325                 330                 335     
Ala Val Glu Gly Leu Glu Leu Thr Glu Ala Thr Pro Gly Tyr Arg Trp
            340                 345                 350         
Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser Gln Glu
        355                 360                 365             
Gly Gln Pro Phe Arg Ala Arg Leu Ser Gly Phe Phe Val Ala Pro Glu
    370                 375                 380                 
Thr Asn Asn Tyr Thr Phe Trp Ile Gln Ala Asp Ser Gln Ala Ser Leu
385                 390                 395                 400 
His Phe Ser Trp Ser Glu Glu Pro Arg Thr Lys Val Lys Val Ala Ser
                405                 410                 415     
Ile Ser Val Gly Thr Ala Asp Trp Phe Asp Ser Trp Glu Gln Asn Arg
            420                 425                 430         
Asp Glu Gly Thr Trp Gln Gln Lys Thr Pro Lys Leu Glu Leu Leu Gly
        435                 440                 445             
Gly Ala Met Tyr Tyr Leu Glu Ala Glu His His Gly Ile Ala Pro Ser
    450                 455                 460                 
Arg Gly Met Arg Ile Gly Val Gln Ile His Asn Thr Trp Leu Asn Pro
465                 470                 475                 480 
Asp Val Val Thr Thr Tyr Leu Arg Glu Lys His Gln Ile Arg Val Arg
                485                 490                 495     
Ala Gln Arg Leu Pro Glu Val Gln Val Leu Asn Val Ser Gly Arg Gly
            500                 505                 510         
Asn Phe Phe Leu Thr Trp Asp Asn Val Ser Ser Gln Pro Ile Pro Ala
        515                 520                 525             
Asn Ala Thr Ala His Leu Ile Gln Thr Thr Ile Glu Glu Leu Leu Ala
    530                 535                 540                 
Val Lys Cys Lys Leu Glu Pro Leu Trp Ser Asn Ile Leu Leu Arg Leu
545                 550                 555                 560 
Gly Phe Glu Arg Gly Pro Glu Val Ser Asn Ser Asp Gly Asp Leu Thr
                565                 570                 575     
Ser Gly Thr Glu Pro Phe Cys Gly Arg Phe Ser Leu Arg Gln Pro Arg
            580                 585                 590         
His Leu Val Leu Thr Pro Pro Ala Ala Gln Lys Gly Tyr Arg Leu Asp
        595                 600                 605             
Gln Tyr Thr His Leu Cys Leu Ala Tyr Lys Gly His Met Asn Lys Ile
    610                 615                 620                 
Leu Lys Met Ile Val Ser Phe Thr Ile Gly Phe Gln Asn Met Val Lys
625                 630                 635                 640 
Asn Thr Thr Cys Asp Trp Ser Leu Thr Arg Thr Ser Pro Glu Ser Trp
                645                 650                 655     
Gln Phe Asp Cys Thr Asp Leu Trp Glu Thr Cys Val Arg Cys Phe Gly
            660                 665                 670         
Asp Leu Gln Pro Pro Pro Ala Asn Ser Pro Val Leu Val His Gln Ile
        675                 680                 685             
Asn Leu Leu Pro Leu Ala Gln Glu Thr Gly Leu Phe Tyr Val Asp Glu
    690                 695                 700                 
Ile Ile Ile Ala Asp Thr Asn Val Thr Val Ser Gln Ala Asp Ser Gly
705                 710                 715                 720 
Thr Ala Arg Pro Gly Gly Asn Leu Val Glu Ser Val Ser Val Val Gly
                725                 730                 735     
Ser Pro Pro Val Tyr Ser Val Thr Ser Trp Leu Ala Gly Cys Gly Thr
            740                 745                 750         
Glu Leu Pro Leu Ile Thr Ala Arg Ser Val Pro Thr Glu Gly Thr Glu
        755                 760                 765             
Glu Gly Ser Gly Leu Val Leu Val Thr Thr Gln Arg Arg Gln Arg Thr
    770                 775                 780                 
Ser Pro Pro Leu Gly Gly His Phe Arg Ile Gln Leu Pro Asn Thr Val
785                 790                 795                 800 
Ile Ser Asp Val Pro Val Gln Ile Ser Ala His His Leu His Gln Leu
                805                 810                 815     
Leu Gln Asn Asn Ala Asp Asp Phe Thr Ser Arg Tyr Leu Asn Ala Ser
            820                 825                 830         
Asp Phe Thr Val Lys Glu Asp Leu Tyr Thr Cys Tyr Glu His Val Trp
        835                 840                 845             
Thr Leu Ser Trp Ser Thr Gln Ile Gly Asp Leu Pro Asn Phe Ile Arg
    850                 855                 860                 
Val Ser Asp Glu Asn Leu Thr Gly Val Asn Pro Ala Ala Ala Thr Arg
865                 870                 875                 880 
Val Val Tyr Asp Gly Gly Val Phe Leu Gly Pro Ile Phe Gly Asp Met
                885                 890                 895     
Leu Ala Thr Ala Asn Gln His Thr Gln Val Val Val Arg Val Asn Asp
            900                 905                 910         
Val Pro Ala His Cys Pro Gly Ser Cys Ser Phe Gln Tyr Leu Gln Gly
        915                 920                 925             
Ser Thr Pro Cys Val His Ser Val Trp Tyr Ser Ile Asp Gly Asp Ile
    930                 935                 940                 
Asn Leu Met Ile Tyr Ile Thr Gly Thr Gly Phe Ser Gly Asp Ser Gln
945                 950                 955                 960 
Phe Leu Gln Val Thr Val Asn Lys Thr Ser Cys Lys Val Ile Phe Ser
                965                 970                 975     
Asn Gln Thr Asn Val Val Cys Gln Thr Asp Leu Leu Pro Val Gly Met
            980                 985                 990         
His Arg Ile Leu Met Leu Val Arg Pro Ser Gly Leu Ala Ile Ser Ala
        995                 1000                1005            
Thr Gly Glu Asp Leu Phe Leu Asn Val Lys Pro Arg Leu Asp Met Val
    1010                1015                1020                
Glu Pro Ser Arg Ala Ala Asp Ile Gly Gly Leu Trp Ala Thr Ile Arg
1025                1030                1035                1040
Gly Ser Ser Leu Glu Gly Val Ser Leu Ile Leu Phe Gly Ser Tyr Ser
                1045                1050                1055    
Cys Ala Ile Asn Val Ala Thr Ser Asn Ser Ser Arg Ile Gln Cys Lys
            1060                1065                1070        
Val Pro Pro Arg Gly Lys Asp Gly Arg Ile Val Asn Val Thr Val Ile
        1075                1080                1085            
Arg Gly Asp Tyr Ser Ala Val Leu Pro Arg Ala Phe Thr Tyr Val Ser
    1090                1095                1100                
Ser Leu Asn Pro Val Ile Val Thr Leu Ser Arg Asn Ile Ser Asn Ile
1105                1110                1115                1120
Ala Gly Gly Glu Thr Leu Val Ile Gly Val Ala Arg Leu Met Asn Tyr
                1125                1130                1135    
Thr Asp Leu Asp Val Glu Val His Val Gln Asp Ala Leu Ala Pro Val
            1140                1145                1150        
His Thr Gln Ser Ala Trp Gly Leu Glu Val Ala Leu Pro Pro Leu Pro
        1155                1160                1165            
Ala Gly Leu His Arg Ile Ser Val Ser Ile Asn Gly Val Ser Ile His
    1170                1175                1180                
Ser Gln Gly Val Asp Leu His Ile Gln Tyr Leu Thr Glu Val Phe Ser
1185                1190                1195                1200
Ile Glu Pro Cys Cys Gly Ser Leu Leu Gly Gly Thr Ile Leu Ser Ile
                1205                1210                1215    
Ser Gly Ile Gly Phe Ser Arg Asp Pro Ala Leu Val Trp Val Leu Val
            1220                1225                1230        
Gly Asn Arg Ser Cys Asp Ile Val Asn Leu Thr Glu Ala Ser Ile Trp
        1235                1240                1245            
Cys Glu Thr Leu Pro Ala Pro Gln Ile Pro Asp Ala Gly Ala Pro Thr
    1250                1255                1260                
Val Pro Ala Ala Val Glu Val Trp Ala Gly Asn Arg Phe Phe Ala Arg
1265                1270                1275                1280
Gly Pro Ser Pro Ser Leu Val Gly Lys Gly Phe Thr Phe Met Tyr Glu
                1285                1290                1295    
Ala Ala Ala Thr Pro Val Val Thr Ala Met Gln Gly Glu Ile Thr Asn
            1300                1305                1310        
Ser Ser Leu Ser Leu His Val Gly Gly Ser Asn Leu Ser Asn Ser Val
        1315                1320                1325            
Ile Leu Leu Gly Asn Leu Asn Cys Asp Val Glu Thr Gln Ser Phe Gln
    1330                1335                1340                
Gly Asn Val Ser Leu Ser Gly Cys Ser Ile Pro Leu His Ser Leu Glu
1345                1350                1355                1360
Ala Gly Ile Tyr Pro Leu Gln Val Arg Gln Lys Gln Met Gly Phe Ala
                1365                1370                1375    
Asn Met Ser Val Val Leu Gln Gln Phe Ala Val Met Pro Arg Ile Met
            1380                1385                1390        
Ala Ile Phe Pro Ser Gln Gly Ser Ala Cys Gly Gly Thr Ile Leu Thr
        1395                1400                1405            
Val Arg Gly Leu Leu Leu Asn Ser Arg Arg Arg Ser Val Arg Val Asp
    1410                1415                1420                
Leu Ser Gly Pro Phe Thr Cys Val Ile Leu Ser Leu Gly Asp His Thr
1425                1430                1435                1440
Ile Leu Cys Gln Val Ser Leu Glu Gly Asp Pro Leu Pro Gly Ala Ser
                1445                1450                1455    
Phe Ser Leu Asn Val Thr Val Leu Val Asn Gly Leu Thr Ser Glu Cys
            1460                1465                1470        
Gln Gly Asn Cys Thr Leu Phe Ile Arg Glu Glu Ala Ser Pro Val Met
        1475                1480                1485            
Asp Ala Leu Ser Thr Asn Thr Ser Gly Ser Leu Thr Thr Val Leu Ile
    1490                1495                1500                
Arg Gly Gln Arg Leu Ala Thr Thr Ala Asp Glu Pro Met Val Phe Val
1505                1510                1515                1520
Asp Asp Gln Leu Pro Cys Asn Val Thr Phe Phe Asn Ala Ser His Val
                1525                1530                1535    
Val Cys Gln Thr Arg Asp Leu Ala Pro Gly Pro His Tyr Leu Ser Val
            1540                1545                1550        
Phe Tyr Thr Arg Asn Gly Tyr Ala Cys Ser Gly Asn Val Ser Arg His
        1555                1560                1565            
Phe Tyr Ile Met Pro Gln Val Phe His Tyr Phe Pro Lys Asn Phe Ser
    1570                1575                1580                
Leu His Gly Gly Ser Leu Leu Thr Ile Glu Gly Thr Gly Leu Arg Gly
1585                1590                1595                1600
Gln Asn Thr Thr Ser Val Tyr Ile Asp Gln Gln Thr Cys Leu Thr Val
                1605                1610                1615    
Asn Ile Gly Ala Glu Leu Ile Arg Cys Ile Val Pro Thr Gly Asn Gly
            1620                1625                1630        
Ser Val Ala Leu Glu Ile Glu Val Asp Gly Leu Trp Tyr His Ile Gly
        1635                1640                1645            
Val Ile Gly Tyr Asn Lys Ala Phe Thr Pro Glu Leu Ile Ser Ile Ser
    1650                1655                1660                
Gln Ser Asp Asp Ile Leu Thr Phe Ala Val Ala Gln Ile Ser Gly Ala
1665                1670                1675                1680
Ala Asn Ile Asp Ile Phe Ile Gly Met Ser Pro Cys Val Gly Val Ser
                1685                1690                1695    
Gly Asn His Thr Val Leu Gln Cys Val Val Pro Ser Leu Pro Ala Gly
            1700                1705                1710        
Glu Tyr His Val Arg Gly Tyr Asp Cys Ile Arg Gly Trp Ala Ser Ser
        1715                1720                1725            
Ala Leu Val Phe Thr Ser Arg Val Ile Ile Thr Ala Val Thr Glu Asn
    1730                1735                1740                
Phe Gly Cys Leu Gly Gly Arg Leu Val His Val Phe Gly Ala Gly Phe
1745                1750                1755                1760
Ser Pro Gly Asn Val Ser Ala Ala Val Cys Gly Ala Pro Cys Arg Val
                1765                1770                1775    
Leu Ala Asn Ala Thr Val Ser Ala Phe Ser Cys Leu Val Leu Pro Leu
            1780                1785                1790        
Asp Val Ser Leu Ala Phe Leu Cys Gly Leu Lys Arg Glu Glu Asp Ser
        1795                1800                1805            
Cys Glu Ala Ala Arg His Thr Tyr Val Gln Cys Asp Leu Thr Val Ala
    1810                1815                1820                
Met Ala Thr Glu Gln Leu Leu Glu Ser Trp Pro Tyr Leu Tyr Ile Cys
1825                1830                1835                1840
Glu Glu Ser Ser Gln Cys Leu Phe Val Pro Asp His Trp Ala Glu Ser
                1845                1850                1855    
Met Phe Pro Ser Phe Ser Gly Leu Phe Ile Ser Pro Lys Leu Glu Arg
            1860                1865                1870        
Asp Glu Val Leu Ile Tyr Asn Ser Ser Cys Asn Ile Thr Met Glu Thr
        1875                1880                1885            
Glu Ala Glu Met Glu Cys Glu Thr Pro Asn Gln Pro Ile Thr Val Lys
    1890                1895                1900                
Ile Thr Glu Ile Arg Lys Arg Trp Gly Gln Asn Thr Gln Gly Asn Phe
1905                1910                1915                1920
Ser Leu Gln Phe Cys Arg Arg Trp Ser Arg Thr His Ser Trp Phe Pro
                1925                1930                1935    
Glu Arg Leu Pro Gln Asp Gly Asp Asn Val Thr Val Glu Asn Gly Gln
            1940                1945                1950        
Leu Leu Leu Leu Asp Thr Asn Thr Ser Ile Leu Asn Leu Leu His Ile
        1955                1960                1965            
Lys Gly Gly Lys Leu Ile Phe Met Ala Pro Gly Pro Ile Glu Leu Arg
    1970                1975                1980                
Ala His Ala Ile Leu Val Ser Asp Gly Gly Glu Leu Arg Ile Gly Ser
1985                1990                1995                2000
Glu Asp Lys Pro Phe Gln Gly Arg Ala Gln Ile Thr Leu Tyr Gly Ser
                2005                2010                2015    
Ser Tyr Ser Thr Pro Phe Phe Pro Tyr Gly Val Lys Phe Leu Ala Val
            2020                2025                2030        
Arg Asn Gly Thr Leu Ser Leu His Gly Ser Leu Pro Glu Val Ile Val
        2035                2040                2045            
Thr Cys Leu Arg Ala Thr Ala His Ala Leu Asp Thr Val Leu Ala Leu
    2050                2055                2060                
Glu Asp Ala Val Asp Trp Asn Pro Gly Asp Glu Val Val Ile Ile Ser
2065                2070                2075                2080
Gly Thr Gly Val Lys Gly Ala Lys Pro Met Glu Glu Ile Val Thr Val
                2085                2090                2095    
Glu Thr Val Gln Asp Thr Asp Leu Tyr Leu Lys Ser Pro Leu Arg Tyr
            2100                2105                2110        
Ser His Asn Phe Thr Glu Asn Trp Val Ala Gly Glu His His Ile Leu
        2115                2120                2125            
Lys Ala Thr Val Ala Leu Leu Ser Arg Ser Ile Thr Ile Gln Gly Asn
    2130                2135                2140                
Leu Thr Asn Glu Arg Glu Lys Leu Leu Val Ser Cys Gln Glu Ala Asn
2145                2150                2155                2160
Ala Pro Glu Gly Asn Leu Gln His Cys Leu Tyr Ser Met Ser Glu Lys
                2165                2170                2175    
Met Leu Gly Ser Arg Asp Met Gly Ala Arg Val Ile Val Gln Ser Phe
            2180                2185                2190        
Pro Glu Glu Pro Ser Gln Val Gln Leu Lys Gly Val Gln Phe Gln Val
        2195                2200                2205            
Leu Gly Gln Ala Phe His Lys His Leu Ser Ser Leu Thr Leu Val Gly
    2210                2215                2220                
Ala Met Arg Glu Ser Phe Ile Gln Gly Cys Thr Val Arg Asn Ser Phe
2225                2230                2235                2240
Ser Arg Gly Leu Ser Met Cys Gly Thr Leu Gly Leu Lys Val Asp Ser
                2245                2250                2255    
Asn Val Phe Tyr Asn Ile Leu Gly His Ala Leu Leu Val Gly Thr Cys
            2260                2265                2270        
Thr Glu Met Arg Tyr Ile Ser Trp Glu Ala Ile His Gly Arg Lys Asp
        2275                2280                2285            
Asp Trp Ser Gly His Gly Asn Ile Ile Arg Asn Asn Val Ile Ile Gln
    2290                2295                2300                
Val Ser Gly Ala Glu Gly Leu Ser Asn Pro Glu Met Leu Thr Pro Ser
2305                2310                2315                2320
Gly Ile Tyr Ile Cys Ser Pro Thr Asn Val Ile Glu Gly Asn Arg Val
                2325                2330                2335    
Cys Gly Ala Gly Tyr Gly Tyr Phe Phe His Leu Met Thr Asn Gln Thr
            2340                2345                2350        
Ser Gln Ala Pro Leu Leu Ser Phe Thr Gln Asn Ile Ala His Ser Cys
        2355                2360                2365            
Thr Arg Tyr Gly Leu Phe Val Tyr Pro Lys Phe Gln Pro Pro Trp Asp
    2370                2375                2380                
Asn Val Thr Gly Thr Thr Leu Phe Gln Ser Phe Thr Val Trp Glu Ser
2385                2390                2395                2400
Ala Gly Gly Ala Gln Ile Phe Arg Ser Ser Asn Leu Arg Leu Lys Asn
                2405                2410                2415    
Phe Lys Val Tyr Ser Cys Arg Asp Phe Gly Ile Asp Val Leu Glu Ser
            2420                2425                2430        
Asp Ala Asn Thr Ser Val Thr Asp Ser Leu Leu Leu Gly His Phe Ala
        2435                2440                2445            
His Lys Gly Ser Leu Cys Met Ser Ser Gly Ile Lys Thr Pro Lys Arg
    2450                2455                2460                
Trp Glu Leu Met Val Ser Asn Thr Thr Phe Val Asn Phe Asp Leu Ile
2465                2470                2475                2480
Asn Cys Val Ala Ile Arg Thr Cys Ser Asp Cys Ser Gln Gly Gln Gly
                2485                2490                2495    
Gly Phe Thr Val Lys Thr Ser Gln Leu Lys Phe Thr Asn Ser Ser Asn
            2500                2505                2510        
Leu Val Ala Phe Pro Phe Pro His Ala Ala Ile Leu Glu Asp Leu Asp
        2515                2520                2525            
Gly Ser Leu Ser Gly Lys Asn Arg Ser His Ile Leu Ala Ser Met Glu
    2530                2535                2540                
Thr Leu Ser Ala Ser Cys Leu Val Asn Ser Ser Phe Gly Arg Val Val
2545                2550                2555                2560
His Gly Ser Ala Cys Gly Gly Gly Val Leu Phe His Arg Met Ser Ile
                2565                2570                2575    
Gly Leu Ala Asn Thr Pro Glu Val Ser Tyr Asp Leu Thr Met Thr Asp
            2580                2585                2590        
Ser Arg Asn Lys Thr Thr Thr Val Asn Tyr Val Arg Asp Thr Leu Ser
        2595                2600                2605            
Asn Pro Arg Gly Trp Met Ala Leu Leu Leu Asp Gln Glu Thr Tyr Ser
    2610                2615                2620                
Leu Gln Ser Glu Asn Leu Trp Ile Asn Arg Ser Leu Gln Tyr Ser Ala
2625                2630                2635                2640
Thr Phe Asp Asn Phe Ala Pro Gly Asn Tyr Leu Leu Leu Val His Thr
                2645                2650                2655    
Asp Leu Pro Pro Tyr Pro Asp Ile Leu Leu Arg Cys Gly Ser Arg Val
            2660                2665                2670        
Gly Leu Ser Phe Pro Phe Leu Pro Ser Pro Gly Gln Asn Gln Gly Cys
        2675                2680                2685            
Asp Trp Phe Phe Asn Ser Gln Leu Arg Gln Leu Thr Tyr Leu Val Ser
    2690                2695                2700                
Gly Glu Gly Gln Val Gln Val Ile Leu Arg Val Lys Glu Gly Met Pro
2705                2710                2715                2720
Pro Thr Ile Ser Ala Ser Thr Ser Ala Pro Glu Ser Ala Leu Lys Trp
                2725                2730                2735    
Ser Leu Pro Glu Thr Trp Gln Gly Val Glu Glu Gly Trp Gly Gly Tyr
            2740                2745                2750        
Asn Asn Thr Ile Pro Gly Pro Gly Asp Asp Val Leu Ile Leu Pro Asn
        2755                2760                2765            
Arg Thr Val Leu Val Asp Thr Asp Leu Pro Phe Phe Lys Gly Leu Tyr
    2770                2775                2780                
Val Met Gly Thr Leu Asp Phe Pro Val Asp Arg Ser Asn Val Leu Ser
2785                2790                2795                2800
Val Ala Cys Met Val Ile Ala Gly Gly Glu Leu Lys Val Gly Thr Leu
                2805                2810                2815    
Glu Asn Pro Leu Glu Lys Glu Gln Lys Leu Leu Ile Leu Leu Arg Ala
            2820                2825                2830        
Ser Glu Gly Val Phe Cys Asp Arg Met Asn Gly Ile His Ile Asp Pro
        2835                2840                2845            
Gly Thr Ile Gly Val Tyr Gly Lys Val His Leu Tyr Ser Ala Tyr Pro
    2850                2855                2860                
Lys Asn Ser Trp Thr His Leu Gly Ala Asp Ile Ala Ser Gly Asn Glu
2865                2870                2875                2880
Arg Ile Ile Val Glu Asp Ala Val Asp Trp Arg Pro His Asp Lys Ile
                2885                2890                2895    
Val Leu Ser Ser Ser Ser Tyr Glu Pro His Glu Ala Glu Val Leu Thr
            2900                2905                2910        
Val Lys Glu Val Lys Gly His His Val Arg Ile Tyr Glu Arg Leu Lys
        2915                2920                2925            
His Arg His Ile Gly Ser Val His Val Thr Glu Asp Gly Arg His Ile
    2930                2935                2940                
Arg Leu Ala Ala Glu Val Gly Leu Leu Thr Arg Asn Ile Gln Ile Gln
2945                2950                2955                2960
Pro Asp Val Ser Cys Arg Gly Arg Leu Phe Val Gly Ser Phe Arg Lys
                2965                2970                2975    
Ser Ser Arg Glu Glu Phe Ser Gly Val Leu Gln Leu Leu Asn Val Glu
            2980                2985                2990        
Ile Gln Asn Phe Gly Ser Pro Leu Tyr Ser Ser Val Glu Phe Ser Asn
        2995                3000                3005            
Val Ser Ala Gly Ser Trp Ile Ile Ser Ser Thr Leu His Gln Ser Cys
    3010                3015                3020                
Gly Gly Gly Ile His Ala Ala Ala Ser His Gly Val Leu Leu Asn Asp
3025                3030                3035                3040
Asn Ile Val Phe Gly Thr Ala Gly His Gly Ile Asp Leu Glu Gly Gln
                3045                3050                3055    
Ala Tyr Thr Val Thr Asn Asn Leu Val Val Leu Met Thr Gln Pro Ala
            3060                3065                3070        
Trp Ser Thr Ile Trp Val Ala Gly Ile Lys Val Asn Gln Val Lys Asp
        3075                3080                3085            
Ile Asn Leu His Gly Asn Val Val Ala Gly Ser Glu Arg Leu Gly Phe
    3090                3095                3100                
His Ile Arg Gly His Lys Cys Ser Ser Cys Glu Leu Leu Trp Ser Asp
3105                3110                3115                3120
Asn Val Ala His Ser Ser Leu His Gly Leu His Leu Tyr Lys Glu Ser
                3125                3130                3135    
Gly Leu Asp Asn Cys Thr Arg Ile Ser Gly Phe Leu Ala Phe Lys Asn
            3140                3145                3150        
Phe Asp Tyr Gly Ala Met Leu His Val Glu Asn Ser Val Glu Ile Glu
        3155                3160                3165            
Asn Ile Thr Leu Val Asp Asn Thr Ile Gly Leu Leu Ala Val Val Tyr
    3170                3175                3180                
Val Phe Ser Ala Pro Gln Asn Ser Val Lys Lys Val Gln Ile Val Leu
3185                3190                3195                3200
Arg Asn Ser Val Ile Val Ala Thr Ser Ser Ser Phe Asp Cys Ile Gln
                3205                3210                3215    
Asp Lys Val Lys Pro His Ser Ala Asn Leu Thr Ser Thr Asp Arg Ala
            3220                3225                3230        
Pro Ser Asn Pro Arg Gly Gly Arg Ile Gly Ile Leu Trp Pro Val Phe
        3235                3240                3245            
Thr Ser Glu Pro Asn Gln Trp Pro Gln Glu Pro Trp His Lys Val Arg
    3250                3255                3260                
Asn Asp His Ser Ile Ser Gly Ile Met Lys Leu Gln Asp Val Thr Phe
3265                3270                3275                3280
Ser Ser Phe Val Lys Ser Cys Tyr Ser Asp Asp Leu Asp Val Cys Ile
                3285                3290                3295    
Leu Pro Asn Ala Glu Asn Ser Gly Ile Met His Pro Ile Thr Ala Glu
            3300                3305                3310        
Arg Thr Arg Met Leu Lys Ile Lys Asp Lys Asn Lys Phe Tyr Phe Pro
        3315                3320                3325            
Ser Leu Gln Pro Arg Lys Asp Leu Gly Lys Val Val Cys Pro Glu Leu
    3330                3335                3340                
Asp Cys Ala Ser Pro Arg Lys Tyr Leu Phe Lys Asp Leu Asp Gly Arg
3345                3350                3355                3360
Ala Leu Gly Leu Pro Pro Pro Val Ser Val Phe Pro Lys Thr Glu Ala
                3365                3370                3375    
Glu Trp Thr Ala Ser Phe Phe Asn Ala Gly Thr Phe Arg Glu Glu Gln
            3380                3385                3390        
Lys Cys Thr Tyr Gln Phe Leu Met Gln Gly Phe Ile Cys Lys Gln Thr
        3395                3400                3405            
Asp Gln Val Val Leu Ile Leu Asp Ser Ala Asp Ala Ile Trp Ala Ile
    3410                3415                3420                
Gln Lys Leu Tyr Pro Val Val Ser Val Thr Ser Gly Phe Val Asp Val
3425                3430                3435                3440
Phe Ser Ser Val Asn Ala Asn Ile Pro Cys Ser Thr Ser Gly Ser Val
                3445                3450                3455    
Ser Thr Phe Tyr Ser Ile Leu Pro Ile Arg Gln Ile Thr Lys Val Cys
            3460                3465                3470        
Phe Met Asp Gln Thr Pro Gln Val Leu Arg Phe Phe Leu Leu Gly Asn
        3475                3480                3485            
Lys Ser Thr Ser Lys Leu Leu Leu Ala Val Phe Tyr His Glu Leu Gln
    3490                3495                3500                
Ser Pro His Val Phe Leu Gly Glu Ser Phe Ile Pro Pro Thr Leu Val
3505                3510                3515                3520
Gln Ser Ala Ser Leu Leu Leu Asn Glu Ser Ile Gly Ala Asn Tyr Phe
                3525                3530                3535    
Asn Ile Met Asp Asn Leu Leu Tyr Val Val Leu Gln Gly Glu Glu Pro
            3540                3545                3550        
Ile Glu Ile Arg Ser Gly Val Ser Ile His Leu Ala Leu Thr Val Met
        3555                3560                3565            
Val Ser Val Leu Glu Lys Gly Trp Glu Ile Val Ile Leu Glu Arg Leu
    3570                3575                3580                
Thr Asn Phe Leu Gln Ile Gly Gln Asn Gln Ile Arg Phe Ile His Glu
3585                3590                3595                3600
Met Pro Gly His Glu Glu Thr Leu Lys Ala Ile Ala Asp Ser Arg Ala
                3605                3610                3615    
Lys Arg Lys Arg Asn Cys Pro Thr Val Thr Cys Thr Ser His Tyr Arg
            3620                3625                3630        
Arg Val Gly Gln Arg Arg Pro Leu Met Met Glu Met Asn Ser His Arg
        3635                3640                3645            
Ala Ser Pro Pro Met Thr Val Glu Thr Ile Ser Lys Val Ile Val Ile
    3650                3655                3660                
Glu Ile Gly Asp Ser Pro Thr Val Arg Ser Thr Gly Met Ile Ser Ser
3665                3670                3675                3680
Leu Ser Ser Asn Lys Leu Gln Asn Leu Ala His Arg Val Ile Thr Ala
                3685                3690                3695    
Gln Gln Thr Gly Val Leu Glu Asn Val Leu Asn Met Thr Ile Gly Ala
            3700                3705                3710        
Leu Leu Val Thr Gln Ser Lys Gly Val Ile Gly Tyr Gly Asn Thr Ser
        3715                3720                3725            
Ser Phe Lys Thr Gly Asn Leu Ile Tyr Ile Arg Pro Tyr Ala Leu Ser
    3730                3735                3740                
Ile Leu Val Gln Pro Ser Asp Gly Glu Val Gly Asn Glu Leu Pro Val
3745                3750                3755                3760
Gln Pro Gln Leu Val Phe Leu Asp Glu Gln Asn Arg Arg Val Glu Ser
                3765                3770                3775    
Leu Gly Pro Pro Ser Glu Pro Trp Thr Ile Ser Ala Ser Leu Glu Gly
            3780                3785                3790        
Ala Ser Asp Ser Val Leu Lys Gly Cys Thr Gln Ala Glu Thr Gln Asp
        3795                3800                3805            
Gly Tyr Val Ser Phe Tyr Asn Leu Ala Val Leu Ile Ser Gly Ser Asn
    3810                3815                3820                
Trp His Phe Ile Phe Thr Val Thr Ser Pro Pro Gly Val Asn Phe Thr
3825                3830                3835                3840
Ala Arg Ser Lys Pro Phe Ala Val Leu Pro Val Thr Arg Lys Glu Lys
                3845                3850                3855    
Ser Thr Ile Ile Leu Ala Ala Ser Leu Ser Ser Val Ala Ser Trp Leu
            3860                3865                3870        
Ala Leu Ser Cys Leu Val Cys Cys Trp Leu Lys Arg Ser Lys Ser Arg
        3875                3880                3885            
Lys Thr Lys Pro Glu Glu Ile Pro Glu Ser Gln Thr Asn Asn Gln Asn
    3890                3895                3900                
Ile His Ile His Ile Ser Ser Lys Arg Arg Glu Ser Gln Gly Pro Lys
3905                3910                3915                3920
Lys Glu Asp Thr Val Val Gly Glu Asp Met Arg Met Lys Val Met Leu
                3925                3930                3935    
Gly Lys Val Asn Gln Cys Pro His Gln Leu Met Asn Gly Val Ser Arg
            3940                3945                3950        
Arg Lys Val Ser Arg His Ile Val Arg Glu Glu Glu Ala Ala Val Pro
        3955                3960                3965            
Ala Pro Gly Thr Thr Gly Ile Thr Ser His Gly His Ile Cys Ala Pro
    3970                3975                3980                
Gly Ala Pro Ala Gln Gln Val Tyr Leu Gln Glu Thr Gly Asn Trp Lys
3985                3990                3995                4000
Glu Gly Gln Glu Gln Leu Leu Arg Tyr Gln Leu Ala Gly Gln Asn Gln
                4005                4010                4015    
Leu Leu Leu Leu Cys Pro Asp Phe Arg Gln Glu Arg Gln Gln Leu Pro
            4020                4025                4030        
Gly Gln Ser Arg Leu Ser Lys Gln Ser Gly Ser Leu Gly Leu Ser Gln
        4035                4040                4045            
Glu Lys Lys Ala Ser Cys Gly Ala Thr Glu Ala Phe Cys Leu His Ser
    4050                4055                4060                
Val His Pro Glu Thr Ile Gln Glu Gln Leu
4065                4070                


<210> 5806
<211> 866
<212> PRT
<213> Homo sapiens

<400> 5806
Met Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu
 1               5                  10                  15      
Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val
            20                  25                  30          
Gly Ser Thr Asn Gly Asn Met Ala Leu Phe Ser Leu Pro Glu Asp Thr
        35                  40                  45              
Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly
    50                  55                  60                  
Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val
65                  70                  75                  80  
Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu
                85                  90                  95      
Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp
            100                 105                 110         
Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala
        115                 120                 125             
Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val
    130                 135                 140                 
Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val
145                 150                 155                 160 
Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn
                165                 170                 175     
Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu
            180                 185                 190         
Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile
        195                 200                 205             
Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val
    210                 215                 220                 
Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln
225                 230                 235                 240 
Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr
                245                 250                 255     
Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp
            260                 265                 270         
Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly
        275                 280                 285             
Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile
    290                 295                 300                 
Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val
305                 310                 315                 320 
Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr
                325                 330                 335     
Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr
            340                 345                 350         
Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn
        355                 360                 365             
Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val
    370                 375                 380                 
Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln Leu Val
385                 390                 395                 400 
Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu
                405                 410                 415     
Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu
            420                 425                 430         
Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val Glu Val Asn Thr
        435                 440                 445             
Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp
    450                 455                 460                 
Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg
465                 470                 475                 480 
Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Val
                485                 490                 495     
Gly Leu Phe Leu Phe Gln Ala Val Asp Pro Asp Thr Gly Pro Trp Gly
            500                 505                 510         
Glu Val Lys Tyr Ser Thr Tyr Gly Thr Gly Ala Asp Leu Phe Leu Ile
        515                 520                 525             
His Pro Ser Thr Gly Leu Ile Tyr Thr Gln Pro Trp Ala Ser Leu Asp
    530                 535                 540                 
Ala Glu Ala Thr Ala Arg Tyr Asn Phe Tyr Val Lys Ala Glu Asp Met
545                 550                 555                 560 
Glu Gly Lys Tyr Ser Val Ala Glu Val Phe Ile Thr Leu Leu Asp Val
                565                 570                 575     
Asn Asp His Pro Pro Gln Phe Gly Lys Ser Val Gln Lys Lys Thr Met
            580                 585                 590         
Val Leu Gly Thr Pro Val Lys Ile Glu Ala Ile Asp Glu Asp Ala Glu
        595                 600                 605             
Glu Pro Asn Asn Leu Val Asp Tyr Ser Ile Thr His Ala Glu Pro Ala
    610                 615                 620                 
Asn Val Phe Asp Ile Asn Ser His Thr Gly Glu Ile Trp Leu Lys Asn
625                 630                 635                 640 
Ser Ile Arg Ser Leu Asp Ala Leu His Asn Ile Thr Pro Gly Arg Asp
                645                 650                 655     
Cys Leu Trp Ser Leu Glu Val Gln Ala Lys Asp Arg Gly Ser Pro Ser
            660                 665                 670         
Phe Ser Thr Thr Ala Leu Leu Lys Ile Asp Ile Thr Asp Ala Glu Thr
        675                 680                 685             
Leu Ser Arg Ser Pro Met Ala Ala Phe Leu Ile Gln Thr Lys Asp Asn
    690                 695                 700                 
Pro Met Lys Ala Val Gly Val Leu Ala Gly Thr Met Ala Thr Val Val
705                 710                 715                 720 
Ala Ile Thr Val Leu Ile Ser Thr Ala Thr Phe Trp Arg Asn Lys Lys
                725                 730                 735     
Ser Asn Lys Val Leu Pro Met Arg Arg Val Leu Arg Lys Arg Pro Ser
            740                 745                 750         
Pro Ala Pro Arg Thr Ile Arg Ile Glu Trp Leu Lys Ser Lys Ser Thr
        755                 760                 765             
Lys Ala Ala Thr Lys Phe Met Leu Lys Glu Lys Pro Pro Asn Glu Asn
    770                 775                 780                 
Cys Asn Asn Asn Ser Pro Glu Ser Ser Leu Leu Pro Arg Ala Pro Ala
785                 790                 795                 800 
Leu Pro Pro Pro Pro Ser Val Ala Pro Ser Thr Gly Ala Ala Gln Trp
                805                 810                 815     
Thr Val Pro Thr Val Ser Gly Ser Leu Thr Pro Gln Pro Thr Gln Pro
            820                 825                 830         
Pro Pro Lys Pro Lys Thr Met Gly Ser Pro Val Gln Ser Thr Leu Ile
        835                 840                 845             
Ser Glu Leu Lys Gln Lys Phe Glu Lys Lys Ser Val His Asn Lys Ala
    850                 855                 860                 
Tyr Phe
865     


<210> 5807
<211> 470
<212> PRT
<213> Homo sapiens

<400> 5807
Met Leu Arg Gly Ile Ser Gln Leu Pro Ala Val Ala Thr Met Ser Trp
 1               5                  10                  15      
Val Leu Leu Pro Val Leu Trp Leu Ile Val Gln Thr Gln Ala Ile Ala
            20                  25                  30          
Ile Lys Gln Thr Pro Glu Leu Thr Leu His Glu Ile Val Cys Pro Lys
        35                  40                  45              
Lys Leu His Ile Leu His Lys Arg Glu Ile Lys Asn Asn Gln Thr Glu
    50                  55                  60                  
Lys His Gly Lys Glu Glu Arg Tyr Glu Pro Glu Val Gln Tyr Gln Met
65                  70                  75                  80  
Ile Leu Asn Gly Glu Glu Ile Ile Leu Ser Leu Gln Lys Thr Lys His
                85                  90                  95      
Leu Leu Gly Pro Asp Tyr Thr Glu Thr Leu Tyr Ser Pro Arg Gly Glu
            100                 105                 110         
Glu Ile Thr Thr Lys Pro Glu Asn Met Glu His Cys Tyr Tyr Lys Gly
        115                 120                 125             
Asn Ile Leu Asn Glu Lys Asn Ser Val Ala Ser Ile Ser Thr Cys Asp
    130                 135                 140                 
Gly Leu Arg Gly Tyr Phe Thr His His His Gln Arg Tyr Gln Ile Lys
145                 150                 155                 160 
Pro Leu Lys Ser Thr Asp Glu Lys Glu His Ala Val Phe Thr Ser Asn
                165                 170                 175     
Gln Glu Glu Gln Asp Pro Ala Asn His Thr Cys Gly Val Lys Ser Thr
            180                 185                 190         
Asp Gly Lys Gln Gly Pro Ile Arg Ile Ser Arg Ser Leu Lys Ser Pro
        195                 200                 205             
Glu Lys Glu Asp Phe Leu Arg Ala Gln Lys Tyr Ile Asp Leu Tyr Leu
    210                 215                 220                 
Val Leu Asp Asn Ala Phe Tyr Lys Asn Tyr Asn Glu Asn Leu Thr Leu
225                 230                 235                 240 
Ile Arg Ser Phe Val Phe Asp Val Met Asn Leu Leu Asn Val Ile Tyr
                245                 250                 255     
Asn Thr Ile Asp Val Gln Val Ala Leu Val Gly Met Glu Ile Trp Ser
            260                 265                 270         
Asp Gly Asp Lys Ile Lys Val Val Pro Ser Ala Ser Thr Thr Phe Asp
        275                 280                 285             
Asn Phe Leu Arg Trp His Ser Ser Asn Leu Gly Lys Lys Ile His Asp
    290                 295                 300                 
His Ala Gln Leu Leu Ser Gly Ile Ser Phe Asn Asn Arg Arg Val Gly
305                 310                 315                 320 
Leu Ala Ala Ser Asn Ser Leu Cys Ser Pro Ser Ser Val Ala Val Ile
                325                 330                 335     
Glu Ala Lys Lys Lys Asn Asn Val Ala Leu Val Gly Val Met Ser His
            340                 345                 350         
Glu Leu Gly His Val Leu Gly Met Pro Asp Val Pro Phe Asn Thr Lys
        355                 360                 365             
Cys Pro Ser Gly Ser Cys Val Met Asn Gln Tyr Leu Ser Ser Lys Phe
    370                 375                 380                 
Pro Lys Asp Phe Ser Thr Ser Cys Arg Ala His Phe Glu Arg Tyr Leu
385                 390                 395                 400 
Leu Ser Gln Lys Pro Lys Cys Leu Leu Gln Ala Pro Ile Pro Thr Asn
                405                 410                 415     
Ile Met Thr Thr Pro Val Cys Gly Asn His Leu Leu Glu Val Gly Glu
            420                 425                 430         
Asp Cys Asp Cys Gly Ser Pro Lys Glu Cys Thr Asn Leu Cys Cys Glu
        435                 440                 445             
Ala Leu Thr Cys Lys Leu Lys Pro Gly Thr Asp Cys Gly Gly Asp Ala
    450                 455                 460                 
Pro Asn His Thr Thr Glu
465                 470 


<210> 5808
<211> 3319
<212> PRT
<213> Homo sapiens

<400> 5808
Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val
 1               5                  10                  15      
Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr
            20                  25                  30          
Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val
        35                  40                  45              
Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro
    50                  55                  60                  
Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val
65                  70                  75                  80  
Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu
                85                  90                  95      
Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly
            100                 105                 110         
Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn
        115                 120                 125             
Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn
    130                 135                 140                 
Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp
145                 150                 155                 160 
Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln
                165                 170                 175     
Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu
            180                 185                 190         
Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr
        195                 200                 205             
Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile
    210                 215                 220                 
Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro
225                 230                 235                 240 
Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg
                245                 250                 255     
Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly
            260                 265                 270         
Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr
        275                 280                 285             
Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro
    290                 295                 300                 
Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn
305                 310                 315                 320 
Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile
                325                 330                 335     
Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu
            340                 345                 350         
Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro
        355                 360                 365             
Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser
    370                 375                 380                 
Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile
385                 390                 395                 400 
Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala
                405                 410                 415     
Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe
            420                 425                 430         
Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile
        435                 440                 445             
Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu
    450                 455                 460                 
Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu
465                 470                 475                 480 
Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser
                485                 490                 495     
Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr
            500                 505                 510         
Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg
        515                 520                 525             
Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr
    530                 535                 540                 
Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr
545                 550                 555                 560 
Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser
                565                 570                 575     
Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro
            580                 585                 590         
Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser
        595                 600                 605             
Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser
    610                 615                 620                 
Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr
625                 630                 635                 640 
Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro
                645                 650                 655     
Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser
            660                 665                 670         
Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala
        675                 680                 685             
Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr
    690                 695                 700                 
Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg
705                 710                 715                 720 
Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg
                725                 730                 735     
Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly
            740                 745                 750         
Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu
        755                 760                 765             
Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr
    770                 775                 780                 
Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val
785                 790                 795                 800 
Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser
                805                 810                 815     
Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys
            820                 825                 830         
Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His
        835                 840                 845             
Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly
    850                 855                 860                 
Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu
865                 870                 875                 880 
Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val
                885                 890                 895     
Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val
            900                 905                 910         
Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg
        915                 920                 925             
Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser
    930                 935                 940                 
Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu
945                 950                 955                 960 
Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser
                965                 970                 975     
Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr
            980                 985                 990         
Pro Thr Phe Phe Pro Ala Val Tyr Asn Val Ser Val Ser Glu Asp Val
        995                 1000                1005            
Pro Arg Glu Phe Arg Val Val Trp Leu Asn Cys Thr Asp Asn Asp Val
    1010                1015                1020                
Gly Leu Asn Ala Glu Leu Ser Tyr Phe Ile Thr Gly Gly Asn Val Asp
1025                1030                1035                1040
Gly Lys Phe Ser Val Gly Tyr Arg Asp Ala Val Val Arg Thr Val Val
                1045                1050                1055    
Gly Leu Asp Arg Glu Thr Thr Ala Ala Tyr Met Leu Ile Leu Glu Ala
            1060                1065                1070        
Ile Asp Asn Gly Pro Val Gly Lys Arg His Thr Gly Thr Ala Thr Val
        1075                1080                1085            
Phe Val Thr Val Leu Asp Val Asn Asp Asn Arg Pro Ile Phe Leu Gln
    1090                1095                1100                
Ser Ser Tyr Glu Ala Ser Val Pro Glu Asp Ile Pro Glu Gly His Ser
1105                1110                1115                1120
Ile Leu Gln Leu Lys Ala Thr Asp Ala Asp Glu Gly Glu Phe Gly Arg
                1125                1130                1135    
Val Trp Tyr Arg Ile Leu His Gly Asn His Gly Asn Asn Phe Arg Ile
            1140                1145                1150        
His Val Ser Asn Gly Leu Leu Met Arg Gly Pro Arg Pro Leu Asp Arg
        1155                1160                1165            
Glu Arg Asn Ser Ser His Val Leu Ile Val Glu Ala Tyr Asn His Asp
    1170                1175                1180                
Leu Gly Pro Met Arg Ser Ser Val Arg Val Ile Val Tyr Val Glu Asp
1185                1190                1195                1200
Ile Asn Asp Glu Ala Pro Val Phe Thr Gln Gln Gln Tyr Ser Arg Leu
                1205                1210                1215    
Gly Leu Arg Glu Thr Ala Gly Ile Gly Thr Ser Val Ile Val Val Gln
            1220                1225                1230        
Ala Thr Asp Arg Asp Ser Gly Asp Gly Gly Leu Val Asn Tyr Arg Ile
        1235                1240                1245            
Leu Ser Gly Ala Glu Gly Lys Phe Glu Ile Asp Glu Ser Thr Gly Leu
    1250                1255                1260                
Ile Ile Thr Val Asn Tyr Leu Asp Tyr Glu Thr Lys Thr Ser Tyr Met
1265                1270                1275                1280
Met Asn Val Ser Ala Thr Asp Gln Ala Pro Pro Phe Asn Gln Gly Phe
                1285                1290                1295    
Cys Ser Val Tyr Ile Thr Leu Leu Asn Glu Leu Asp Glu Ala Val Gln
            1300                1305                1310        
Phe Ser Asn Ala Ser Tyr Glu Ala Ala Ile Leu Glu Asn Leu Ala Leu
        1315                1320                1325            
Gly Thr Glu Ile Val Arg Val Gln Ala Tyr Ser Ile Asp Asn Leu Asn
    1330                1335                1340                
Gln Ile Thr Tyr Arg Phe Asp Ala Tyr Thr Ser Thr Gln Ala Lys Ala
1345                1350                1355                1360
Leu Phe Lys Ile Asp Ala Ile Thr Gly Val Ile Thr Val Gln Gly Leu
                1365                1370                1375    
Val Asp Arg Glu Lys Gly Asp Phe Tyr Thr Leu Thr Val Val Ala Asp
            1380                1385                1390        
Asp Gly Gly Pro Lys Val Asp Ser Thr Val Lys Val Tyr Ile Thr Val
        1395                1400                1405            
Leu Asp Glu Asn Asp Asn Ser Pro Arg Phe Asp Phe Thr Ser Asp Ser
    1410                1415                1420                
Ala Val Ser Ile Pro Glu Asp Cys Pro Val Gly Gln Arg Val Ala Thr
1425                1430                1435                1440
Val Lys Ala Trp Asp Pro Asp Ala Gly Ser Asn Gly Gln Val Val Phe
                1445                1450                1455    
Ser Leu Ala Ser Gly Asn Ile Ala Gly Ala Phe Glu Ile Val Thr Thr
            1460                1465                1470        
Asn Asp Ser Ile Gly Glu Val Phe Val Ala Arg Pro Leu Asp Arg Glu
        1475                1480                1485            
Glu Leu Asp His Tyr Ile Leu Gln Val Val Ala Ser Asp Arg Gly Thr
    1490                1495                1500                
Pro Pro Arg Lys Lys Asp His Ile Leu Gln Val Thr Ile Leu Asp Ile
1505                1510                1515                1520
Asn Asp Asn Pro Pro Val Ile Glu Ser Pro Phe Gly Tyr Asn Val Ser
                1525                1530                1535    
Val Asn Glu Asn Val Gly Gly Gly Thr Ala Val Val Gln Val Arg Ala
            1540                1545                1550        
Thr Asp Arg Asp Ile Gly Ile Asn Ser Val Leu Ser Tyr Tyr Ile Thr
        1555                1560                1565            
Glu Gly Asn Lys Asp Met Thr Phe Arg Met Asp Arg Ile Ser Gly Glu
    1570                1575                1580                
Ile Ala Thr Arg Pro Ala Pro Pro Asp Arg Glu Arg Gln Ser Phe Tyr
1585                1590                1595                1600
His Leu Val Ala Thr Val Glu Asp Glu Gly Thr Pro Thr Leu Ser Ala
                1605                1610                1615    
Thr Thr His Val Tyr Val Thr Ile Val Asp Glu Asn Asp Asn Ala Pro
            1620                1625                1630        
Met Phe Gln Gln Pro His Tyr Glu Val Leu Leu Asp Glu Gly Pro Asp
        1635                1640                1645            
Thr Leu Asn Thr Ser Leu Ile Thr Ile Gln Ala Leu Asp Leu Asp Glu
    1650                1655                1660                
Gly Pro Asn Gly Thr Val Thr Tyr Ala Ile Val Ala Gly Asn Ile Val
1665                1670                1675                1680
Asn Thr Phe Arg Ile Asp Arg His Met Gly Val Ile Thr Ala Ala Lys
                1685                1690                1695    
Glu Leu Asp Tyr Glu Ile Ser His Gly Arg Tyr Thr Leu Ile Val Thr
            1700                1705                1710        
Ala Thr Asp Gln Cys Pro Ile Leu Ser His Arg Leu Thr Ser Thr Thr
        1715                1720                1725            
Thr Val Leu Val Asn Val Asn Asp Ile Asn Asp Asn Val Pro Thr Phe
    1730                1735                1740                
Pro Arg Asp Tyr Glu Gly Pro Phe Glu Val Thr Glu Gly Gln Pro Gly
1745                1750                1755                1760
Pro Arg Val Trp Thr Phe Leu Ala His Asp Arg Asp Ser Gly Pro Asn
                1765                1770                1775    
Gly Gln Val Glu Tyr Ser Ile Met Asp Gly Asp Pro Leu Gly Glu Phe
            1780                1785                1790        
Val Ile Ser Pro Val Glu Gly Val Leu Arg Val Arg Lys Asp Val Glu
        1795                1800                1805            
Leu Asp Arg Glu Thr Ile Ala Phe Tyr Asn Leu Thr Ile Cys Ala Arg
    1810                1815                1820                
Asp Arg Gly Met Pro Pro Leu Ser Ser Thr Met Leu Val Gly Ile Arg
1825                1830                1835                1840
Val Leu Asp Ile Asn Asp Asn Asp Pro Val Leu Leu Asn Leu Pro Met
                1845                1850                1855    
Asn Ile Thr Ile Ser Glu Asn Ser Pro Val Ser Ser Phe Val Ala His
            1860                1865                1870        
Val Leu Ala Ser Asp Ala Asp Ser Gly Cys Asn Ala Arg Leu Thr Phe
        1875                1880                1885            
Asn Ile Thr Ala Gly Asn Arg Glu Arg Ala Phe Phe Ile Asn Ala Thr
    1890                1895                1900                
Thr Gly Ile Val Thr Val Asn Arg Pro Leu Asp Arg Glu Arg Ile Pro
1905                1910                1915                1920
Glu Tyr Lys Leu Thr Ile Ser Val Lys Asp Asn Pro Glu Asn Pro Arg
                1925                1930                1935    
Ile Ala Arg Arg Asp Tyr Asp Leu Leu Leu Ile Phe Leu Ser Asp Glu
            1940                1945                1950        
Asn Asp Asn His Pro Leu Phe Thr Lys Ser Thr Tyr Gln Ala Glu Val
        1955                1960                1965            
Met Glu Asn Ser Pro Ala Gly Thr Pro Leu Thr Val Leu Asn Gly Pro
    1970                1975                1980                
Ile Leu Ala Leu Asp Ala Asp Gln Asp Ile Tyr Ala Val Val Thr Tyr
1985                1990                1995                2000
Gln Leu Leu Gly Ala Gln Ser Gly Leu Phe Asp Ile Asn Ser Ser Thr
                2005                2010                2015    
Gly Val Val Thr Val Arg Ser Gly Val Ile Ile Asp Arg Glu Ala Phe
            2020                2025                2030        
Ser Pro Pro Ile Leu Glu Leu Leu Leu Leu Ala Glu Asp Ile Gly Leu
        2035                2040                2045            
Leu Asn Ser Thr Ala His Leu Leu Ile Thr Ile Leu Asp Asp Asn Asp
    2050                2055                2060                
Asn Arg Pro Thr Phe Ser Pro Ala Thr Leu Thr Val His Leu Leu Glu
2065                2070                2075                2080
Asn Cys Pro Pro Gly Phe Ser Val Leu Gln Val Thr Ala Thr Asp Glu
                2085                2090                2095    
Asp Ser Gly Leu Asn Gly Glu Leu Val Tyr Arg Ile Glu Ala Gly Ala
            2100                2105                2110        
Gln Asp Arg Phe Leu Ile His Leu Val Thr Gly Val Ile Arg Val Gly
        2115                2120                2125            
Asn Ala Thr Ile Asp Arg Glu Glu Gln Glu Ser Tyr Arg Leu Thr Val
    2130                2135                2140                
Val Ala Thr Asp Arg Gly Thr Val Pro Leu Ser Gly Thr Ala Ile Val
2145                2150                2155                2160
Thr Ile Leu Ile Asp Asp Ile Asn Asp Ser Arg Pro Glu Phe Leu Asn
                2165                2170                2175    
Pro Ile Gln Thr Val Ser Val Leu Glu Ser Ala Glu Pro Gly Thr Val
            2180                2185                2190        
Ile Ala Asn Ile Thr Ala Ile Asp His Asp Leu Asn Pro Lys Leu Glu
        2195                2200                2205            
Tyr His Ile Val Gly Ile Val Ala Lys Asp Asp Thr Asp Arg Leu Val
    2210                2215                2220                
Pro Asn Gln Glu Asp Ala Phe Ala Val Asn Ile Asn Thr Gly Ser Val
2225                2230                2235                2240
Met Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr Glu Val
                2245                2250                2255    
Thr Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val
            2260                2265                2270        
Ser Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val Asn Asp
        2275                2280                2285            
Asn Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met Glu Arg
    2290                2295                2300                
Ile Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val Ala Ala
2305                2310                2315                2320
Val Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr Leu Leu
                2325                2330                2335    
Asp Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser Ala Gly
            2340                2345                2350        
Lys Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His Trp Leu
        2355                2360                2365            
Asn Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg Ala Ala
    2370                2375                2380                
Glu Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn Asn Pro
2385                2390                2395                2400
Ile Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp Val Pro
                2405                2410                2415    
Val Gly Thr Ile Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Ser Gly
            2420                2425                2430        
Asn Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser Lys Phe
        2435                2440                2445            
Ala Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser Leu Asp
    2450                2455                2460                
Arg Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys Asp Asn
2465                2470                2475                2480
Pro Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln Val Val
                2485                2490                2495    
Ile Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser Lys Pro
            2500                2505                2510        
Gln Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr Ser Val
        2515                2520                2525            
Ile Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly Glu Leu
    2530                2535                2540                
Thr Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val Asp Met
2545                2550                2555                2560
Asp Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr Glu Lys
                2565                2570                2575    
Phe Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro Leu Trp
            2580                2585                2590        
Gly Thr Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp Asn Arg
        2595                2600                2605            
Pro Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile Arg Glu
    2610                2615                2620                
Glu Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr Asp Lys
2625                2630                2635                2640
Asp Glu Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe Leu Lys Thr Ala
                2645                2650                2655    
Gly Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser Gly Leu
            2660                2665                2670        
Ile Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val Tyr Ser
        2675                2680                2685            
Leu Ile Leu Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr Glu Thr
    2690                2695                2700                
Met Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn Glu Pro
2705                2710                2715                2720
Leu Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu Leu Thr
                2725                2730                2735    
Val Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val Thr Gly
            2740                2745                2750        
Ala Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr Phe Ile
        2755                2760                2765            
Ala Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp Gly Cys
    2770                2775                2780                
Leu Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile Phe Ser
2785                2790                2795                2800
Phe Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro Arg Gly
                2805                2810                2815    
Pro Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln Glu Val
            2820                2825                2830        
Arg Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe Thr Lys
        2835                2840                2845            
Ala Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly Ser Glu
    2850                2855                2860                
Leu Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn Ser Leu
2865                2870                2875                2880
Val Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu Ala Asn
                2885                2890                2895    
Asp Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met Asp Gly
            2900                2905                2910        
Ile Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly Tyr Phe
        2915                2920                2925            
Val Val Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp Thr Ala
    2930                2935                2940                
Ile Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lys Ile Val
2945                2950                2955                2960
Ile Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Phe Ile
                2965                2970                2975    
His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp Asn Val
            2980                2985                2990        
Gln Phe His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln Thr Glu
        2995                3000                3005            
Leu Leu Ile His Val Val Asn Arg Asp Thr Asn Arg Ile Leu Asp Val
    3010                3015                3020                
Asp Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu Arg Asn
3025                3030                3035                3040
Leu Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile Ser Val
                3045                3050                3055    
Arg Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile Val Leu
            3060                3065                3070        
Ala Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met Asn Trp
        3075                3080                3085            
Tyr Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val Ala Gly
    3090                3095                3100                
Ser Ala Gly Asn Arg Gly Phe Ile Asp Ile Met Asp Met Pro Asn Thr
3105                3110                3115                3120
Asn Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp Pro Phe
                3125                3130                3135    
Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp Leu
            3140                3145                3150        
Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr Arg
        3155                3160                3165            
Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp Asp
    3170                3175                3180                
Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala Lys
3185                3190                3195                3200
Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Leu Ile Gln Thr Glu
                3205                3210                3215    
Leu Asp Glu Glu Pro Gly Asp His Ser Pro Gly Gln Gly Ser Leu Arg
            3220                3225                3230        
Phe Arg His Lys Pro Pro Val Glu Leu Lys Gly Pro Asp Gly Ile His
        3235                3240                3245            
Val Val His Gly Ser Thr Gly Thr Leu Leu Ala Thr Asp Leu Asn Ser
    3250                3255                3260                
Leu Pro Glu Glu Asp Gln Lys Gly Leu Gly Arg Ser Leu Glu Thr Leu
3265                3270                3275                3280
Thr Ala Ala Glu Ala Thr Ala Phe Glu Arg Asn Ala Arg Thr Glu Ser
                3285                3290                3295    
Ala Lys Ser Thr Pro Leu His Lys Leu Arg Asp Val Ile Met Glu Thr
            3300                3305                3310        
Pro Leu Glu Ile Thr Glu Leu
        3315                


<210> 5809
<211> 3358
<212> PRT
<213> Homo sapiens

<400> 5809
Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val
 1               5                  10                  15      
Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr
            20                  25                  30          
Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val
        35                  40                  45              
Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro
    50                  55                  60                  
Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val
65                  70                  75                  80  
Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu
                85                  90                  95      
Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly
            100                 105                 110         
Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn
        115                 120                 125             
Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn
    130                 135                 140                 
Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp
145                 150                 155                 160 
Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln
                165                 170                 175     
Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu
            180                 185                 190         
Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr
        195                 200                 205             
Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile
    210                 215                 220                 
Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro
225                 230                 235                 240 
Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg
                245                 250                 255     
Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly
            260                 265                 270         
Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr
        275                 280                 285             
Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro
    290                 295                 300                 
Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn
305                 310                 315                 320 
Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile
                325                 330                 335     
Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu
            340                 345                 350         
Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro
        355                 360                 365             
Leu Phe Ile Gln Val Val Asp Lys Asp Glu Gly Leu Asn Ser Met Phe
    370                 375                 380                 
Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile Ser Pro
385                 390                 395                 400 
Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala Ile Pro
                405                 410                 415     
Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe Ala Asn
            420                 425                 430         
Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile Thr Leu
        435                 440                 445             
Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu Tyr Asn
    450                 455                 460                 
Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu Thr Val
465                 470                 475                 480 
Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser Tyr Phe
                485                 490                 495     
Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr Gly Leu
            500                 505                 510         
Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg Phe Thr
        515                 520                 525             
Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr Gly Arg
    530                 535                 540                 
Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr Phe Gln
545                 550                 555                 560 
Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser Val Thr
                565                 570                 575     
Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro Asn Asn
            580                 585                 590         
Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser Tyr Phe
        595                 600                 605             
Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser Arg Pro
    610                 615                 620                 
Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr Val Met
625                 630                 635                 640 
Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro Val Thr
                645                 650                 655     
Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser Lys Pro
            660                 665                 670         
Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala Thr Val
        675                 680                 685             
Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr Gly Gln
    690                 695                 700                 
Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg Ile Asn
705                 710                 715                 720 
Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg Glu Thr
                725                 730                 735     
Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly Val Gly
            740                 745                 750         
His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu Leu Asp
        755                 760                 765             
Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr Ile Asn
    770                 775                 780                 
Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val Val Ala
785                 790                 795                 800 
Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser Ile Gln
                805                 810                 815     
Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys Ile Arg
            820                 825                 830         
Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His Glu Ala
        835                 840                 845             
Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly Arg Pro
    850                 855                 860                 
Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu Leu Asp
865                 870                 875                 880 
Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val Ala Glu
                885                 890                 895     
Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val Val Ala
            900                 905                 910         
Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg Met Pro
        915                 920                 925             
Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser Gly Val
    930                 935                 940                 
Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu Tyr Gln
945                 950                 955                 960 
Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser Ser Thr
                965                 970                 975     
Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr Pro Thr
            980                 985                 990         
Phe Phe Pro Ala Val Tyr Asn Val Ser Val Ser Glu Asp Val Pro Arg
        995                 1000                1005            
Glu Phe Arg Val Val Trp Leu Asn Cys Thr Asp Asn Asp Val Gly Leu
    1010                1015                1020                
Asn Ala Glu Leu Ser Tyr Phe Ile Thr Gly Gly Asn Val Asp Gly Lys
1025                1030                1035                1040
Phe Ser Val Gly Tyr Arg Asp Ala Val Val Arg Thr Val Val Gly Leu
                1045                1050                1055    
Asp Arg Glu Thr Thr Ala Ala Tyr Met Leu Ile Leu Glu Ala Ile Asp
            1060                1065                1070        
Asn Gly Pro Val Gly Lys Arg His Thr Gly Thr Ala Thr Val Phe Val
        1075                1080                1085            
Thr Val Leu Asp Val Asn Asp Asn Arg Pro Ile Phe Leu Gln Ser Ser
    1090                1095                1100                
Tyr Glu Ala Ser Val Pro Glu Asp Ile Pro Glu Gly His Ser Ile Leu
1105                1110                1115                1120
Gln Ala Ala Thr Asp Ala Asp Glu Gly Glu Phe Gly Arg Val Trp Tyr
                1125                1130                1135    
Arg Ile Leu His Gly Asn His Gly Asn Asn Phe Arg Ile His Val Ser
            1140                1145                1150        
Asn Gly Leu Leu Met Arg Gly Pro Arg Pro Leu Asp Arg Glu Arg Asn
        1155                1160                1165            
Ser Ser His Val Leu Ile Val Glu Ala Tyr Asn His Asp Leu Gly Pro
    1170                1175                1180                
Met Arg Ser Ser Val Arg Val Ile Val Tyr Val Glu Asp Ile Asn Asp
1185                1190                1195                1200
Glu Ala Pro Val Phe Thr Gln Gln Gln Tyr Ser Arg Leu Gly Leu Arg
                1205                1210                1215    
Glu Thr Ala Gly Ile Gly Thr Ser Val Ile Val Val Gln Ala Thr Asp
            1220                1225                1230        
Arg Asp Ser Gly Asp Gly Gly Leu Val Asn Tyr Arg Ile Leu Ser Gly
        1235                1240                1245            
Ala Glu Gly Lys Phe Glu Ile Asp Glu Ser Thr Gly Leu Ile Ile Thr
    1250                1255                1260                
Val Asn Tyr Leu Asp Tyr Glu Thr Lys Thr Ser Tyr Met Met Asn Val
1265                1270                1275                1280
Ser Ala Thr Asp Gln Ala Pro Pro Phe Asn Gln Gly Phe Cys Ser Val
                1285                1290                1295    
Tyr Ile Thr Leu Leu Asn Glu Leu Asp Glu Ala Val Gln Phe Ser Asn
            1300                1305                1310        
Ala Ser Tyr Glu Ala Ala Ile Leu Glu Asn Leu Ala Leu Gly Thr Glu
        1315                1320                1325            
Ile Val Arg Val Gln Ala Tyr Ser Ile Asp Asn Leu Asn Gln Ile Thr
    1330                1335                1340                
Tyr Arg Phe Asn Ala Tyr Thr Ser Thr Gln Ala Lys Ala Leu Phe Lys
1345                1350                1355                1360
Ile Asp Ala Ile Thr Gly Val Ile Thr Val Gln Gly Leu Val Asp Arg
                1365                1370                1375    
Glu Lys Gly Asp Phe Tyr Thr Leu Thr Val Val Ala Asp Asp Gly Gly
            1380                1385                1390        
Pro Lys Val Asp Ser Thr Val Val Ser Asp His Val His Pro Gln Val
        1395                1400                1405            
Tyr Ile Thr Val Leu Asp Glu Asn Asp Asn Ser Pro Arg Phe Asp Phe
    1410                1415                1420                
Thr Ser Asp Ser Ala Val Ser Ile Pro Glu Asp Cys Pro Val Gly Gln
1425                1430                1435                1440
Arg Val Ala Thr Val Lys Ala Trp Asp Pro Asp Ala Gly Ser Asn Gly
                1445                1450                1455    
Gln Val Val Phe Ser Leu Ala Ser Gly Asn Ile Ala Gly Ala Phe Glu
            1460                1465                1470        
Ile Val Thr Thr Asn Asp Ser Ile Gly Glu Val Phe Val Ala Arg Pro
        1475                1480                1485            
Leu Asp Arg Glu Glu Leu Asp His Tyr Ile Leu Gln Val Val Ala Ser
    1490                1495                1500                
Asp Arg Gly Thr Pro Pro Arg Lys Lys Asp His Ile Leu Gln Val Thr
1505                1510                1515                1520
Ile Leu Asp Ile Asn Asp Asn Pro Pro Val Ile Glu Ser Pro Phe Gly
                1525                1530                1535    
Tyr Asn Val Ser Val Asn Glu Asn Val Gly Gly Gly Thr Ala Val Val
            1540                1545                1550        
Gln Val Arg Ala Thr Asp Arg Asp Ile Gly Ile Asn Ser Val Leu Ser
        1555                1560                1565            
Tyr Tyr Ile Thr Glu Gly Asn Lys Asp Met Ala Phe Arg Met Asp Arg
    1570                1575                1580                
Ile Ser Gly Glu Ile Ala Thr Arg Pro Ala Pro Pro Asp Arg Glu Arg
1585                1590                1595                1600
Gln Ser Phe Tyr His Leu Val Ala Thr Val Glu Asp Glu Gly Thr Pro
                1605                1610                1615    
Thr Leu Ser Ala Thr Thr His Val Tyr Val Thr Ile Val Asp Glu Asn
            1620                1625                1630        
Asp Asn Ala Pro Met Phe Gln Gln Pro His Tyr Glu Val Leu Leu Asp
        1635                1640                1645            
Glu Gly Pro Asp Thr Leu Asn Thr Ser Leu Ile Thr Ile Gln Ala Leu
    1650                1655                1660                
Asp Leu Asp Glu Gly Pro Asn Gly Thr Val Thr Tyr Ala Ile Val Ala
1665                1670                1675                1680
Gly Asn Ile Val Asn Thr Phe Arg Ile Asp Arg His Met Gly Val Ile
                1685                1690                1695    
Thr Ala Ala Lys Glu Leu Asp Tyr Glu Ile Ser His Gly Arg Tyr Thr
            1700                1705                1710        
Leu Ile Val Thr Ala Thr Asp Gln Cys Pro Ile Leu Ser His Arg Leu
        1715                1720                1725            
Thr Ser Thr Thr Thr Val Leu Val Asn Val Asn Asp Ile Asn Asp Asn
    1730                1735                1740                
Val Pro Thr Phe Pro Arg Asp Tyr Glu Gly Pro Phe Glu Val Thr Glu
1745                1750                1755                1760
Gly Gln Pro Gly Pro Arg Val Trp Thr Phe Leu Ala His Asp Arg Asp
                1765                1770                1775    
Ser Gly Pro Asn Gly Gln Val Glu Tyr Ser Ile Met Asp Gly Asp Pro
            1780                1785                1790        
Leu Gly Glu Phe Val Ile Ser Pro Val Glu Gly Val Leu Arg Val Arg
        1795                1800                1805            
Lys Asp Val Glu Leu Asp Arg Glu Thr Ile Ala Phe Tyr Asn Leu Thr
    1810                1815                1820                
Ile Cys Ala Arg Asp Arg Gly Met Pro Pro Leu Ser Ser Thr Met Leu
1825                1830                1835                1840
Val Gly Ile Arg Val Leu Asp Ile Asn Asp Asn Asp Pro Val Leu Leu
                1845                1850                1855    
Asn Leu Pro Met Asn Ile Thr Ile Ser Glu Asn Ser Pro Val Ser Ser
            1860                1865                1870        
Phe Val Ala His Val Leu Ala Ser Asp Ala Asp Ser Gly Cys Asn Ala
        1875                1880                1885            
Arg Leu Thr Phe Asn Ile Thr Ala Gly Asn Arg Glu Arg Ala Phe Phe
    1890                1895                1900                
Ile Asn Ala Thr Thr Gly Ile Val Thr Val Asn Arg Pro Leu Asp Arg
1905                1910                1915                1920
Glu Arg Ile Pro Glu Tyr Lys Leu Thr Ile Ser Val Lys Asp Asn Pro
                1925                1930                1935    
Glu Asn Pro Arg Ile Ala Arg Arg Asp Tyr Asp Leu Leu Leu Ile Phe
            1940                1945                1950        
Leu Ser Asp Glu Asn Asp Asn His Pro Leu Phe Thr Lys Ser Thr Tyr
        1955                1960                1965            
Gln Ala Glu Val Met Glu Asn Ser Pro Ala Gly Thr Pro Leu Thr Val
    1970                1975                1980                
Leu Asn Gly Pro Ile Leu Ala Leu Asp Ala Asp Gln Asp Ile Tyr Ala
1985                1990                1995                2000
Val Val Thr Tyr Gln Leu Leu Gly Ala Gln Ser Gly Leu Phe Asp Ile
                2005                2010                2015    
Asn Ser Ser Thr Gly Val Val Thr Val Arg Ser Gly Val Ile Ile Asp
            2020                2025                2030        
Arg Glu Ala Phe Ser Pro Pro Ile Leu Glu Leu Leu Leu Leu Ala Glu
        2035                2040                2045            
Asp Ile Gly Leu Leu Asn Ser Thr Ala His Leu Leu Ile Thr Ile Leu
    2050                2055                2060                
Asp Asp Asn Asp Asn Arg Pro Thr Phe Ser Pro Ala Thr Leu Thr Val
2065                2070                2075                2080
His Leu Leu Glu Asn Cys Pro Pro Gly Phe Ser Val Leu Gln Val Thr
                2085                2090                2095    
Ala Thr Asp Glu Asp Ser Gly Leu Asn Gly Glu Leu Val Tyr Arg Ile
            2100                2105                2110        
Glu Ala Gly Ala Gln Asp Arg Phe Leu Ile His Leu Val Thr Gly Val
        2115                2120                2125            
Ile Arg Val Gly Asn Ala Thr Ile Asp Arg Glu Glu Gln Glu Ser Tyr
    2130                2135                2140                
Arg Leu Thr Val Val Ala Thr Asp Arg Gly Thr Val Pro Leu Ser Gly
2145                2150                2155                2160
Thr Ala Ile Val Thr Ile Leu Ile Asp Asp Ile Asn Asp Ser Arg Pro
                2165                2170                2175    
Glu Phe Leu Asn Pro Ile Gln Thr Val Ser Val Leu Glu Ser Ala Glu
            2180                2185                2190        
Pro Gly Thr Val Ile Ala Asn Ile Thr Ala Ile Asp His Asp Leu Asn
        2195                2200                2205            
Pro Lys Leu Glu Tyr His Ile Val Gly Ile Val Ala Lys Asp Asp Thr
    2210                2215                2220                
Asp Arg Leu Val Pro Asn Gln Glu Asp Ala Phe Ala Val Asn Ile Asn
2225                2230                2235                2240
Thr Gly Ser Val Met Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala
                2245                2250                2255    
Thr Tyr Glu Val Thr Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro
            2260                2265                2270        
Glu Arg Ser Val Ser Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu
        2275                2280                2285            
Asp Val Asn Asp Asn Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr
    2290                2295                2300                
Tyr Met Glu Arg Ile Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile
2305                2310                2315                2320
Ala Val Ala Ala Val Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr
                2325                2330                2335    
Tyr Thr Leu Leu Asp Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp
            2340                2345                2350        
Ser Ser Ala Gly Lys Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu
        2355                2360                2365            
Val His Trp Leu Asn Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro
    2370                2375                2380                
Pro Arg Ala Ala Glu Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn
2385                2390                2395                2400
Asp Asn Asn Pro Ile Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe
                2405                2410                2415    
Glu Asp Val Pro Val Gly Thr Ile Ile Leu Thr Val Thr Ala Thr Asp
            2420                2425                2430        
Ala Asp Ser Gly Asn Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly
        2435                2440                2445            
Glu Ser Lys Phe Ala Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu
    2450                2455                2460                
Ser Ser Leu Asp Arg Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu
2465                2470                2475                2480
Ala Lys Asp Asn Pro Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser
                2485                2490                2495    
Val Gln Val Val Ile Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln
            2500                2505                2510        
Phe Ser Lys Pro Gln Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala
        2515                2520                2525            
Gly Thr Ser Val Ile Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro
    2530                2535                2540                
Asn Gly Glu Leu Thr Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe
2545                2550                2555                2560
His Val Asp Met Asp Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln
                2565                2570                2575    
Ser Tyr Glu Lys Phe Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu
            2580                2585                2590        
Pro Pro Leu Trp Gly Thr Thr Met Leu Leu Val Glu Val Ile Asp Val
        2595                2600                2605            
Asn Asp Asn Arg Pro Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu
    2610                2615                2620                
His Ile Arg Glu Glu Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr
2625                2630                2635                2640
Ala Thr Asp Lys Asp Glu Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe
                2645                2650                2655    
Leu Lys Thr Ala Gly Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro
            2660                2665                2670        
Ile Ser Gly Leu Ile Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln
        2675                2680                2685            
Ala Val Tyr Ser Leu Ile Leu Val Ala Ser Asp Leu Gly Gln Pro Val
    2690                2695                2700                
Pro Tyr Glu Thr Met Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp
2705                2710                2715                2720
Asp Asn Glu Pro Leu Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr
                2725                2730                2735    
Gln Leu Leu Thr Val Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly
            2740                2745                2750        
Asn Val Thr Gly Ala Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val
        2755                2760                2765            
Tyr Tyr Phe Ile Ala Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln
    2770                2775                2780                
Pro Asp Gly Cys Leu Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu
2785                2790                2795                2800
Ala Ile Phe Ser Phe Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr
                2805                2810                2815    
Pro Pro Arg Gly Pro Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr
            2820                2825                2830        
Leu Gln Glu Val Arg Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro
        2835                2840                2845            
Arg Phe Thr Lys Ala Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys
    2850                2855                2860                
Val Gly Ser Glu Leu Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly
2865                2870                2875                2880
Asn Asn Ser Leu Val Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg
                2885                2890                2895    
Ala Leu Ala Asn Asp Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly
            2900                2905                2910        
Ser Met Asp Gly Ile Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser
        2915                2920                2925            
Pro Gly Tyr Phe Val Val Asp Ile Val Ala Arg Asp Leu Ala Gly His
    2930                2935                2940                
Asn Asp Thr Ala Ile Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg
2945                2950                2955                2960
Val Lys Ile Val Ile Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu
                2965                2970                2975    
Glu Glu Phe Ile His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn
            2980                2985                2990        
Thr Asp Asn Val Gln Phe His Val Asp Lys Lys Gly Arg Val Asn Phe
        2995                3000                3005            
Ala Gln Thr Glu Leu Leu Ile His Val Val Asn Arg Asp Thr Asn Arg
    3010                3015                3020                
Ile Leu Asp Val Asp Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu
3025                3030                3035                3040
Gln Leu Arg Asn Leu Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro
                3045                3050                3055    
Ala Ile Ser Val Arg Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala
            3060                3065                3070        
Ile Ile Val Leu Ala Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val
        3075                3080                3085            
Leu Met Asn Trp Tyr Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala
    3090                3095                3100                
Ile Val Ala Gly Ser Ala Gly Asn Arg Gly Phe Ile Asp Ile Met Asp
3105                3110                3115                3120
Met Pro Asn Thr Asn Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp
                3125                3130                3135    
Leu Asp Pro Phe Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His
            3140                3145                3150        
Glu Asp Asp Leu Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn
        3155                3160                3165            
Ser Pro Thr Arg Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val
    3170                3175                3180                
Lys Pro Asp Asp Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp
3185                3190                3195                3200
Asn Ile Ala Lys Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Gly
                3205                3210                3215    
Ser Leu Leu Lys Val Val Leu Glu Asp Tyr Leu Arg Leu Lys Lys Leu
            3220                3225                3230        
Phe Ala Gln Arg Met Val Gln Lys Ala Ser Ser Cys His Ser Ser Ile
        3235                3240                3245            
Ser Glu Leu Ile Gln Thr Glu Leu Asp Glu Glu Pro Gly Asp His Ser
    3250                3255                3260                
Pro Gly Gln Gly Ser Leu Arg Phe Arg His Lys Pro Pro Val Glu Leu
3265                3270                3275                3280
Lys Gly Pro Asp Gly Ile His Val Val His Gly Ser Thr Gly Thr Leu
                3285                3290                3295    
Leu Ala Thr Asp Leu Asn Ser Leu Pro Glu Glu Asp Gln Lys Gly Leu
            3300                3305                3310        
Gly Arg Ser Leu Glu Thr Leu Thr Ala Ala Glu Ala Thr Ala Phe Glu
        3315                3320                3325            
Arg Asn Ala Arg Thr Glu Ser Ala Lys Ser Thr Pro Leu His Lys Leu
    3330                3335                3340                
Arg Asp Val Ile Met Glu Thr Pro Leu Glu Ile Thr Glu Leu
3345                3350                3355            


<210> 5810
<211> 3353
<212> PRT
<213> Homo sapiens

<400> 5810
Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val
 1               5                  10                  15      
Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr
            20                  25                  30          
Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val
        35                  40                  45              
Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro
    50                  55                  60                  
Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val
65                  70                  75                  80  
Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu
                85                  90                  95      
Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly
            100                 105                 110         
Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn
        115                 120                 125             
Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn
    130                 135                 140                 
Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp
145                 150                 155                 160 
Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln
                165                 170                 175     
Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu
            180                 185                 190         
Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr
        195                 200                 205             
Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile
    210                 215                 220                 
Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro
225                 230                 235                 240 
Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg
                245                 250                 255     
Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly
            260                 265                 270         
Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr
        275                 280                 285             
Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro
    290                 295                 300                 
Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn
305                 310                 315                 320 
Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile
                325                 330                 335     
Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu
            340                 345                 350         
Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro
        355                 360                 365             
Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser
    370                 375                 380                 
Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile
385                 390                 395                 400 
Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala
                405                 410                 415     
Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe
            420                 425                 430         
Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile
        435                 440                 445             
Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu
    450                 455                 460                 
Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu
465                 470                 475                 480 
Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser
                485                 490                 495     
Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr
            500                 505                 510         
Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg
        515                 520                 525             
Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr
    530                 535                 540                 
Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr
545                 550                 555                 560 
Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser
                565                 570                 575     
Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro
            580                 585                 590         
Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser
        595                 600                 605             
Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser
    610                 615                 620                 
Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr
625                 630                 635                 640 
Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro
                645                 650                 655     
Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser
            660                 665                 670         
Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala
        675                 680                 685             
Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr
    690                 695                 700                 
Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg
705                 710                 715                 720 
Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg
                725                 730                 735     
Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly
            740                 745                 750         
Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu
        755                 760                 765             
Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr
    770                 775                 780                 
Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val
785                 790                 795                 800 
Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser
                805                 810                 815     
Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys
            820                 825                 830         
Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His
        835                 840                 845             
Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly
    850                 855                 860                 
Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu
865                 870                 875                 880 
Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val
                885                 890                 895     
Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val
            900                 905                 910         
Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg
        915                 920                 925             
Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser
    930                 935                 940                 
Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu
945                 950                 955                 960 
Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser
                965                 970                 975     
Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr
            980                 985                 990         
Pro Thr Phe Phe Pro Ala Val Tyr Asn Val Ser Val Ser Glu Asp Val
        995                 1000                1005            
Pro Arg Glu Phe Arg Val Val Trp Leu Asn Cys Thr Asp Asn Asp Val
    1010                1015                1020                
Gly Leu Asn Ala Glu Leu Ser Tyr Phe Ile Thr Gly Gly Asn Val Asp
1025                1030                1035                1040
Gly Lys Phe Ser Val Gly Tyr Arg Asp Ala Val Val Arg Thr Val Val
                1045                1050                1055    
Gly Leu Asp Arg Glu Thr Thr Ala Ala Tyr Met Leu Ile Leu Glu Ala
            1060                1065                1070        
Ile Asp Asn Gly Pro Val Gly Lys Arg His Thr Gly Thr Ala Thr Val
        1075                1080                1085            
Phe Val Thr Val Leu Asp Val Asn Asp Asn Arg Pro Ile Phe Leu Gln
    1090                1095                1100                
Ser Ser Tyr Glu Ala Ser Val Pro Glu Asp Ile Pro Glu Gly His Ser
1105                1110                1115                1120
Ile Leu Gln Leu Lys Ala Thr Asp Ala Asp Glu Gly Glu Phe Gly Arg
                1125                1130                1135    
Val Trp Tyr Arg Ile Leu His Gly Asn His Gly Asn Asn Phe Arg Ile
            1140                1145                1150        
His Val Ser Asn Gly Leu Leu Met Arg Gly Pro Arg Pro Leu Asp Arg
        1155                1160                1165            
Glu Arg Asn Ser Ser His Val Leu Ile Val Glu Ala Tyr Asn His Asp
    1170                1175                1180                
Leu Gly Pro Met Arg Ser Ser Val Arg Val Ile Val Tyr Val Glu Asp
1185                1190                1195                1200
Ile Asn Asp Glu Ala Pro Val Phe Thr Gln Gln Gln Tyr Ser Arg Leu
                1205                1210                1215    
Gly Leu Arg Glu Thr Ala Gly Ile Gly Thr Ser Val Ile Val Val Gln
            1220                1225                1230        
Ala Thr Asp Arg Asp Ser Gly Asp Gly Gly Leu Val Asn Tyr Arg Ile
        1235                1240                1245            
Leu Ser Gly Ala Glu Gly Lys Phe Glu Ile Asp Glu Ser Thr Gly Leu
    1250                1255                1260                
Ile Ile Thr Val Asn Tyr Leu Asp Tyr Glu Thr Lys Thr Ser Tyr Met
1265                1270                1275                1280
Met Asn Val Ser Ala Thr Asp Gln Ala Pro Pro Phe Asn Gln Gly Phe
                1285                1290                1295    
Cys Ser Val Tyr Ile Thr Leu Leu Asn Glu Leu Asp Glu Ala Val Gln
            1300                1305                1310        
Phe Ser Asn Ala Ser Tyr Glu Ala Ala Ile Leu Glu Asn Leu Ala Leu
        1315                1320                1325            
Gly Thr Glu Ile Val Arg Val Gln Ala Tyr Ser Ile Asp Asn Leu Asn
    1330                1335                1340                
Gln Ile Thr Tyr Arg Phe Asp Ala Tyr Thr Ser Thr Gln Ala Lys Ala
1345                1350                1355                1360
Leu Phe Lys Ile Asp Ala Ile Thr Gly Val Ile Thr Val Gln Gly Leu
                1365                1370                1375    
Val Asp Arg Glu Lys Gly Asp Phe Tyr Thr Leu Thr Val Val Ala Asp
            1380                1385                1390        
Asp Gly Gly Pro Lys Val Asp Ser Thr Val Val Tyr Ile Thr Val Leu
        1395                1400                1405            
Asp Glu Asn Asp Asn Ser Pro Arg Phe Asp Phe Thr Ser Asp Ser Ala
    1410                1415                1420                
Val Ser Ile Pro Glu Asp Cys Pro Val Gly Gln Arg Val Ala Thr Val
1425                1430                1435                1440
Lys Ala Trp Asp Pro Asp Ala Gly Ser Asn Gly Gln Val Val Phe Ser
                1445                1450                1455    
Leu Ala Ser Gly Asn Ile Ala Gly Ala Phe Glu Ile Val Thr Thr Asn
            1460                1465                1470        
Asp Ser Ile Gly Glu Val Phe Val Ala Arg Pro Leu Asp Arg Glu Glu
        1475                1480                1485            
Leu Asp His Tyr Ile Leu Gln Val Val Ala Ser Asp Arg Gly Thr Pro
    1490                1495                1500                
Pro Arg Lys Lys Asp His Ile Leu Gln Val Thr Ile Leu Asp Ile Asn
1505                1510                1515                1520
Asp Asn Pro Pro Val Ile Glu Ser Pro Phe Gly Tyr Asn Val Ser Val
                1525                1530                1535    
Asn Glu Asn Val Gly Gly Gly Thr Ala Val Val Gln Val Arg Ala Thr
            1540                1545                1550        
Asp Arg Asp Ile Gly Ile Asn Ser Val Leu Ser Tyr Tyr Ile Thr Glu
        1555                1560                1565            
Gly Asn Lys Asp Met Thr Phe Arg Met Asp Arg Ile Ser Gly Glu Ile
    1570                1575                1580                
Ala Thr Arg Pro Ala Pro Pro Asp Arg Glu Arg Gln Ser Phe Tyr His
1585                1590                1595                1600
Leu Val Ala Thr Val Glu Asp Glu Gly Thr Pro Thr Leu Ser Ala Thr
                1605                1610                1615    
Thr His Val Tyr Val Thr Ile Val Asp Glu Asn Asp Asn Ala Pro Met
            1620                1625                1630        
Phe Gln Gln Pro His Tyr Glu Val Leu Leu Asp Glu Gly Pro Asp Thr
        1635                1640                1645            
Leu Asn Thr Ser Leu Ile Thr Ile Gln Ala Leu Asp Leu Asp Glu Gly
    1650                1655                1660                
Pro Asn Gly Thr Val Thr Tyr Ala Ile Val Ala Gly Asn Ile Val Asn
1665                1670                1675                1680
Thr Phe Arg Ile Asp Arg His Met Gly Val Ile Thr Ala Ala Lys Glu
                1685                1690                1695    
Leu Asp Tyr Glu Ile Ser His Gly Arg Tyr Thr Leu Ile Val Thr Ala
            1700                1705                1710        
Thr Asp Gln Cys Pro Ile Leu Ser His Arg Leu Thr Ser Thr Thr Thr
        1715                1720                1725            
Val Leu Val Asn Val Asn Asp Ile Asn Asp Asn Val Pro Thr Phe Pro
    1730                1735                1740                
Arg Asp Tyr Glu Gly Pro Phe Glu Val Thr Glu Gly Gln Pro Gly Pro
1745                1750                1755                1760
Arg Val Trp Thr Phe Leu Ala His Asp Arg Asp Ser Gly Pro Asn Gly
                1765                1770                1775    
Gln Val Glu Tyr Ser Ile Met Asp Gly Asp Pro Leu Gly Glu Phe Val
            1780                1785                1790        
Ile Ser Pro Val Glu Gly Val Leu Arg Val Arg Lys Asp Val Glu Leu
        1795                1800                1805            
Asp Arg Glu Thr Ile Ala Phe Tyr Asn Leu Thr Ile Cys Ala Arg Asp
    1810                1815                1820                
Arg Gly Met Pro Pro Leu Ser Ser Thr Met Leu Val Gly Ile Arg Val
1825                1830                1835                1840
Leu Asp Ile Asn Asp Asn Asp Pro Val Leu Leu Asn Leu Pro Met Asn
                1845                1850                1855    
Ile Thr Ile Ser Glu Asn Ser Pro Val Ser Ser Phe Val Ala His Val
            1860                1865                1870        
Leu Ala Ser Asp Ala Asp Ser Gly Cys Asn Ala Arg Leu Thr Phe Asn
        1875                1880                1885            
Ile Thr Ala Gly Asn Arg Glu Arg Ala Phe Phe Ile Asn Ala Thr Thr
    1890                1895                1900                
Gly Ile Val Thr Val Asn Arg Pro Leu Asp Arg Glu Arg Ile Pro Glu
1905                1910                1915                1920
Tyr Lys Leu Thr Ile Ser Val Lys Asp Asn Pro Glu Asn Pro Arg Ile
                1925                1930                1935    
Ala Arg Arg Asp Tyr Asp Leu Leu Leu Ile Phe Leu Ser Asp Glu Asn
            1940                1945                1950        
Asp Asn His Pro Leu Phe Thr Lys Ser Thr Tyr Gln Ala Glu Val Met
        1955                1960                1965            
Glu Asn Ser Pro Ala Gly Thr Pro Leu Thr Val Leu Asn Gly Pro Ile
    1970                1975                1980                
Leu Ala Leu Asp Ala Asp Gln Asp Ile Tyr Ala Val Val Thr Tyr Gln
1985                1990                1995                2000
Leu Leu Gly Ala Gln Ser Gly Leu Phe Asp Ile Asn Ser Ser Thr Gly
                2005                2010                2015    
Val Val Thr Val Arg Ser Gly Val Ile Ile Asp Arg Glu Ala Phe Ser
            2020                2025                2030        
Pro Pro Ile Leu Glu Leu Leu Leu Leu Ala Glu Asp Ile Gly Leu Leu
        2035                2040                2045            
Asn Ser Thr Ala His Leu Leu Ile Thr Ile Leu Asp Asp Asn Asp Asn
    2050                2055                2060                
Arg Pro Thr Phe Ser Pro Ala Thr Leu Thr Val His Leu Leu Glu Asn
2065                2070                2075                2080
Cys Pro Pro Gly Phe Ser Val Leu Gln Val Thr Ala Thr Asp Glu Asp
                2085                2090                2095    
Ser Gly Leu Asn Gly Glu Leu Val Tyr Arg Ile Glu Ala Gly Ala Gln
            2100                2105                2110        
Asp Arg Phe Leu Ile His Leu Val Thr Gly Val Ile Arg Val Gly Asn
        2115                2120                2125            
Ala Thr Ile Asp Arg Glu Glu Gln Glu Ser Tyr Arg Leu Thr Val Val
    2130                2135                2140                
Ala Thr Asp Arg Gly Thr Val Pro Leu Ser Gly Thr Ala Ile Val Thr
2145                2150                2155                2160
Ile Leu Ile Asp Asp Ile Asn Asp Ser Arg Pro Glu Phe Leu Asn Pro
                2165                2170                2175    
Ile Gln Thr Val Ser Val Leu Glu Ser Ala Glu Pro Gly Thr Val Ile
            2180                2185                2190        
Ala Asn Ile Thr Ala Ile Asp His Asp Leu Asn Pro Lys Leu Glu Tyr
        2195                2200                2205            
His Ile Val Gly Ile Val Ala Lys Asp Asp Thr Asp Arg Leu Val Pro
    2210                2215                2220                
Asn Gln Glu Asp Ala Phe Ala Val Asn Ile Asn Thr Gly Ser Val Met
2225                2230                2235                2240
Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr Glu Val Thr
                2245                2250                2255    
Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val Ser
            2260                2265                2270        
Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val Asn Asp Asn
        2275                2280                2285            
Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met Glu Arg Ile
    2290                2295                2300                
Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val Ala Ala Val
2305                2310                2315                2320
Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr Leu Leu Asp
                2325                2330                2335    
Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser Ala Gly Lys
            2340                2345                2350        
Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His Trp Leu Asn
        2355                2360                2365            
Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg Ala Ala Glu
    2370                2375                2380                
Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn Asn Pro Ile
2385                2390                2395                2400
Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp Val Pro Val
                2405                2410                2415    
Gly Thr Ile Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Ser Gly Asn
            2420                2425                2430        
Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser Lys Phe Ala
        2435                2440                2445            
Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser Leu Asp Arg
    2450                2455                2460                
Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys Asp Asn Pro
2465                2470                2475                2480
Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln Val Val Ile
                2485                2490                2495    
Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser Lys Pro Gln
            2500                2505                2510        
Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr Ser Val Ile
        2515                2520                2525            
Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly Glu Leu Thr
    2530                2535                2540                
Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val Asp Met Asp
2545                2550                2555                2560
Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr Glu Lys Phe
                2565                2570                2575    
Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro Leu Trp Gly
            2580                2585                2590        
Thr Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp Asn Arg Pro
        2595                2600                2605            
Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile Arg Glu Glu
    2610                2615                2620                
Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr Asp Lys Asp
2625                2630                2635                2640
Glu Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe Leu Lys Thr Ala Gly
                2645                2650                2655    
Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser Gly Leu Ile
            2660                2665                2670        
Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val Tyr Ser Leu
        2675                2680                2685            
Ile Leu Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr Glu Thr Met
    2690                2695                2700                
Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn Glu Pro Leu
2705                2710                2715                2720
Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu Leu Thr Val
                2725                2730                2735    
Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val Thr Gly Ala
            2740                2745                2750        
Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr Phe Ile Ala
        2755                2760                2765            
Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp Gly Cys Leu
    2770                2775                2780                
Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile Phe Ser Phe
2785                2790                2795                2800
Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro Arg Gly Pro
                2805                2810                2815    
Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln Glu Val Arg
            2820                2825                2830        
Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe Thr Lys Ala
        2835                2840                2845            
Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly Ser Glu Leu
    2850                2855                2860                
Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn Ser Leu Val
2865                2870                2875                2880
Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu Ala Asn Asp
                2885                2890                2895    
Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met Asp Gly Ile
            2900                2905                2910        
Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly Tyr Phe Val
        2915                2920                2925            
Val Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp Thr Ala Ile
    2930                2935                2940                
Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lys Ile Val Ile
2945                2950                2955                2960
Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Phe Ile His
                2965                2970                2975    
Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp Asn Val Gln
            2980                2985                2990        
Phe His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln Thr Glu Leu
        2995                3000                3005            
Leu Ile His Val Val Asn Arg Asp Thr Asn Arg Ile Leu Asp Val Asp
    3010                3015                3020                
Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu Arg Asn Leu
3025                3030                3035                3040
Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile Ser Val Arg
                3045                3050                3055    
Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile Val Leu Ala
            3060                3065                3070        
Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met Asn Trp Tyr
        3075                3080                3085            
Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val Ala Gly Ser
    3090                3095                3100                
Ala Gly Asn Arg Gly Phe Ile Asp Ile Met Asp Met Pro Asn Thr Asn
3105                3110                3115                3120
Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp Pro Phe Cys
                3125                3130                3135    
Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp Leu Pro
            3140                3145                3150        
Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr Arg Thr
        3155                3160                3165            
His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp Asp Asp
    3170                3175                3180                
Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala Lys Leu
3185                3190                3195                3200
Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Gly Ser Leu Leu Lys Val
                3205                3210                3215    
Val Leu Glu Asp Tyr Leu Arg Leu Lys Lys Leu Phe Ala Gln Arg Met
            3220                3225                3230        
Val Gln Lys Ala Ser Ser Cys His Ser Ser Ile Ser Glu Leu Ile Gln
        3235                3240                3245            
Thr Glu Leu Asp Glu Glu Pro Gly Asp His Ser Pro Gly Gln Gly Ser
    3250                3255                3260                
Leu Arg Phe Arg His Lys Pro Pro Val Glu Leu Lys Gly Pro Asp Gly
3265                3270                3275                3280
Ile His Val Val His Gly Ser Thr Gly Thr Leu Leu Ala Thr Asp Leu
                3285                3290                3295    
Asn Ser Leu Pro Glu Glu Asp Gln Lys Gly Leu Gly Arg Ser Leu Glu
            3300                3305                3310        
Thr Leu Thr Ala Ala Glu Ala Thr Ala Phe Glu Arg Asn Ala Arg Thr
        3315                3320                3325            
Glu Ser Ala Lys Ser Thr Pro Leu His Lys Leu Arg Asp Val Ile Met
    3330                3335                3340                
Glu Thr Pro Leu Glu Ile Thr Glu Leu
3345                3350            


<210> 5811
<211> 3352
<212> PRT
<213> Homo sapiens

<400> 5811
Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val
 1               5                  10                  15      
Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr
            20                  25                  30          
Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val
        35                  40                  45              
Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro
    50                  55                  60                  
Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val
65                  70                  75                  80  
Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu
                85                  90                  95      
Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly
            100                 105                 110         
Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn
        115                 120                 125             
Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn
    130                 135                 140                 
Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp
145                 150                 155                 160 
Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln
                165                 170                 175     
Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu
            180                 185                 190         
Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr
        195                 200                 205             
Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile
    210                 215                 220                 
Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro
225                 230                 235                 240 
Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg
                245                 250                 255     
Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly
            260                 265                 270         
Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr
        275                 280                 285             
Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro
    290                 295                 300                 
Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn
305                 310                 315                 320 
Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile
                325                 330                 335     
Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu
            340                 345                 350         
Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro
        355                 360                 365             
Leu Phe Ile Gln Val Val Asp Lys Asp Glu Gly Leu Asn Ser Met Phe
    370                 375                 380                 
Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile Ser Pro
385                 390                 395                 400 
Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala Ile Pro
                405                 410                 415     
Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe Ala Asn
            420                 425                 430         
Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile Thr Leu
        435                 440                 445             
Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu Tyr Asn
    450                 455                 460                 
Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu Thr Val
465                 470                 475                 480 
Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser Tyr Phe
                485                 490                 495     
Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr Gly Leu
            500                 505                 510         
Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg Phe Thr
        515                 520                 525             
Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr Gly Arg
    530                 535                 540                 
Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr Phe Gln
545                 550                 555                 560 
Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser Val Thr
                565                 570                 575     
Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro Asn Asn
            580                 585                 590         
Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser Tyr Phe
        595                 600                 605             
Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser Arg Pro
    610                 615                 620                 
Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr Val Met
625                 630                 635                 640 
Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro Val Thr
                645                 650                 655     
Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser Lys Pro
            660                 665                 670         
Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala Thr Val
        675                 680                 685             
Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr Gly Gln
    690                 695                 700                 
Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg Ile Asn
705                 710                 715                 720 
Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg Glu Thr
                725                 730                 735     
Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly Val Gly
            740                 745                 750         
His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu Leu Asp
        755                 760                 765             
Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr Ile Asn
    770                 775                 780                 
Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val Val Ala
785                 790                 795                 800 
Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser Ile Gln
                805                 810                 815     
Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys Ile Arg
            820                 825                 830         
Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His Glu Ala
        835                 840                 845             
Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly Arg Pro
    850                 855                 860                 
Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu Leu Asp
865                 870                 875                 880 
Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val Ala Glu
                885                 890                 895     
Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val Val Ala
            900                 905                 910         
Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg Met Pro
        915                 920                 925             
Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser Gly Val
    930                 935                 940                 
Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu Tyr Gln
945                 950                 955                 960 
Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser Ser Thr
                965                 970                 975     
Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr Pro Thr
            980                 985                 990         
Phe Phe Pro Ala Val Tyr Asn Val Ser Val Ser Glu Asp Val Pro Arg
        995                 1000                1005            
Glu Phe Arg Val Val Trp Leu Asn Cys Thr Asp Asn Asp Val Gly Leu
    1010                1015                1020                
Asn Ala Glu Leu Ser Tyr Phe Ile Thr Gly Gly Asn Val Asp Gly Lys
1025                1030                1035                1040
Phe Ser Val Gly Tyr Arg Asp Ala Val Val Arg Thr Val Val Gly Leu
                1045                1050                1055    
Asp Arg Glu Thr Thr Ala Ala Tyr Met Leu Ile Leu Glu Ala Ile Asp
            1060                1065                1070        
Asn Gly Pro Val Gly Lys Arg His Thr Gly Thr Ala Thr Val Phe Val
        1075                1080                1085            
Thr Val Leu Asp Val Asn Asp Asn Arg Pro Ile Phe Leu Gln Ser Ser
    1090                1095                1100                
Tyr Glu Ala Ser Val Pro Glu Asp Ile Pro Glu Gly His Ser Ile Leu
1105                1110                1115                1120
Gln Leu Lys Ala Thr Asp Ala Asp Glu Gly Glu Phe Gly Arg Val Trp
                1125                1130                1135    
Tyr Arg Ile Leu His Gly Asn His Gly Asn Asn Phe Arg Ile His Val
            1140                1145                1150        
Ser Asn Gly Leu Leu Met Arg Gly Pro Arg Pro Leu Asp Arg Glu Arg
        1155                1160                1165            
Asn Ser Ser His Val Leu Ile Val Glu Ala Tyr Asn His Asp Leu Gly
    1170                1175                1180                
Pro Met Arg Ser Ser Val Arg Val Ile Val Tyr Val Glu Asp Ile Asn
1185                1190                1195                1200
Asp Glu Ala Pro Val Phe Thr Gln Gln Gln Tyr Ser Arg Leu Gly Leu
                1205                1210                1215    
Arg Glu Thr Ala Gly Ile Gly Thr Ser Val Ile Val Val Gln Ala Thr
            1220                1225                1230        
Asp Arg Asp Ser Gly Asp Gly Gly Leu Val Asn Tyr Arg Ile Leu Ser
        1235                1240                1245            
Gly Ala Glu Gly Lys Phe Glu Ile Asp Glu Ser Thr Gly Leu Ile Ile
    1250                1255                1260                
Thr Val Asn Tyr Leu Asp Tyr Glu Thr Lys Thr Ser Tyr Met Met Asn
1265                1270                1275                1280
Val Ser Ala Thr Asp Gln Ala Pro Pro Phe Asn Gln Gly Phe Cys Ser
                1285                1290                1295    
Val Tyr Ile Thr Leu Leu Asn Glu Leu Asp Glu Ala Val Gln Phe Ser
            1300                1305                1310        
Asn Ala Ser Tyr Glu Ala Ala Ile Leu Glu Asn Leu Ala Leu Gly Thr
        1315                1320                1325            
Glu Ile Val Arg Val Gln Ala Tyr Ser Ile Asp Asn Leu Asn Gln Ile
    1330                1335                1340                
Thr Tyr Arg Phe Asp Ala Tyr Thr Ser Thr Gln Ala Lys Ala Leu Phe
1345                1350                1355                1360
Lys Ile Asp Ala Ile Thr Gly Val Ile Thr Val Gln Gly Leu Val Asp
                1365                1370                1375    
Arg Glu Lys Gly Asp Phe Tyr Thr Leu Thr Val Val Ala Asp Asp Gly
            1380                1385                1390        
Gly Pro Lys Val Asp Ser Thr Val Lys Val Tyr Ile Thr Val Leu Asp
        1395                1400                1405            
Glu Asn Asp Asn Ser Pro Arg Phe Asp Phe Thr Ser Asp Ser Ala Val
    1410                1415                1420                
Ser Ile Pro Glu Asp Cys Pro Val Gly Gln Arg Val Ala Thr Val Lys
1425                1430                1435                1440
Ala Trp Asp Pro Asp Ala Gly Ser Asn Gly Gln Val Val Phe Ser Leu
                1445                1450                1455    
Ala Ser Gly Asn Ile Ala Gly Ala Phe Glu Ile Val Thr Thr Asn Asp
            1460                1465                1470        
Ser Ile Gly Glu Val Phe Val Ala Arg Pro Leu Asp Arg Glu Glu Leu
        1475                1480                1485            
Asp His Tyr Ile Leu Gln Val Val Ala Ser Asp Arg Gly Thr Pro Pro
    1490                1495                1500                
Arg Lys Lys Asp His Ile Leu Gln Val Thr Ile Leu Asp Ile Asn Asp
1505                1510                1515                1520
Asn Pro Pro Val Ile Glu Ser Pro Phe Gly Tyr Asn Val Ser Val Asn
                1525                1530                1535    
Glu Asn Val Gly Gly Gly Thr Ala Val Val Gln Val Arg Ala Thr Asp
            1540                1545                1550        
Arg Asp Ile Gly Ile Asn Ser Val Leu Ser Tyr Tyr Ile Thr Glu Gly
        1555                1560                1565            
Asn Lys Asp Met Thr Phe Arg Met Asp Arg Ile Ser Gly Glu Ile Ala
    1570                1575                1580                
Thr Arg Pro Ala Pro Pro Asp Arg Glu Arg Gln Ser Phe Tyr His Leu
1585                1590                1595                1600
Val Ala Thr Val Glu Asp Glu Gly Thr Pro Thr Leu Ser Ala Thr Thr
                1605                1610                1615    
His Val Tyr Val Thr Ile Val Asp Glu Asn Asp Asn Ala Pro Met Phe
            1620                1625                1630        
Gln Gln Pro His Tyr Glu Val Leu Leu Asp Glu Gly Pro Asp Thr Leu
        1635                1640                1645            
Asn Thr Ser Leu Ile Thr Ile Gln Ala Leu Asp Leu Asp Glu Gly Pro
    1650                1655                1660                
Asn Gly Thr Val Thr Tyr Ala Ile Val Ala Gly Asn Ile Val Asn Thr
1665                1670                1675                1680
Phe Arg Ile Asp Arg His Met Gly Val Ile Thr Ala Ala Lys Glu Leu
                1685                1690                1695    
Asp Tyr Glu Ile Ser His Gly Arg Tyr Thr Leu Ile Val Thr Ala Thr
            1700                1705                1710        
Asp Gln Cys Pro Ile Leu Ser His Arg Leu Thr Ser Thr Thr Thr Val
        1715                1720                1725            
Leu Val Asn Val Asn Asp Ile Asn Asp Asn Val Pro Thr Phe Pro Arg
    1730                1735                1740                
Asp Tyr Glu Gly Pro Phe Glu Val Thr Glu Gly Gln Pro Gly Pro Arg
1745                1750                1755                1760
Val Trp Thr Phe Leu Ala His Asp Arg Asp Ser Gly Pro Asn Gly Gln
                1765                1770                1775    
Val Glu Tyr Ser Ile Met Asp Gly Asp Pro Leu Gly Glu Phe Val Ile
            1780                1785                1790        
Ser Pro Val Glu Gly Val Leu Arg Val Arg Lys Asp Val Glu Leu Asp
        1795                1800                1805            
Arg Glu Thr Ile Ala Phe Tyr Asn Leu Thr Ile Cys Ala Arg Asp Arg
    1810                1815                1820                
Gly Met Pro Pro Leu Ser Ser Thr Met Leu Val Gly Ile Arg Val Leu
1825                1830                1835                1840
Asp Ile Asn Asp Asn Asp Pro Val Leu Leu Asn Leu Pro Met Asn Ile
                1845                1850                1855    
Thr Ile Ser Glu Asn Ser Pro Val Ser Ser Phe Val Ala His Val Leu
            1860                1865                1870        
Ala Ser Asp Ala Asp Ser Gly Cys Asn Ala Arg Leu Thr Phe Asn Ile
        1875                1880                1885            
Thr Ala Gly Asn Arg Glu Arg Ala Phe Phe Ile Asn Ala Thr Thr Gly
    1890                1895                1900                
Ile Val Thr Val Asn Arg Pro Leu Asp Arg Glu Arg Ile Pro Glu Tyr
1905                1910                1915                1920
Lys Leu Thr Ile Ser Val Lys Asp Asn Pro Glu Asn Pro Arg Ile Ala
                1925                1930                1935    
Arg Arg Asp Tyr Asp Leu Leu Leu Ile Phe Leu Ser Asp Glu Asn Asp
            1940                1945                1950        
Asn His Pro Leu Phe Thr Lys Ser Thr Tyr Gln Ala Glu Val Met Glu
        1955                1960                1965            
Asn Ser Pro Ala Gly Thr Pro Leu Thr Val Leu Asn Gly Pro Ile Leu
    1970                1975                1980                
Ala Leu Asp Ala Asp Gln Asp Ile Tyr Ala Val Val Thr Tyr Gln Leu
1985                1990                1995                2000
Leu Gly Ala Gln Ser Gly Leu Phe Asp Ile Asn Ser Ser Thr Gly Val
                2005                2010                2015    
Val Thr Val Arg Ser Gly Val Ile Ile Asp Arg Glu Ala Phe Ser Pro
            2020                2025                2030        
Pro Ile Leu Glu Leu Leu Leu Leu Ala Glu Asp Ile Gly Leu Leu Asn
        2035                2040                2045            
Ser Thr Ala His Leu Leu Ile Thr Ile Leu Asp Asp Asn Asp Asn Arg
    2050                2055                2060                
Pro Thr Phe Ser Pro Ala Thr Leu Thr Val His Leu Leu Glu Asn Cys
2065                2070                2075                2080
Pro Pro Gly Phe Ser Val Leu Gln Val Thr Ala Thr Asp Glu Asp Ser
                2085                2090                2095    
Gly Leu Asn Gly Glu Leu Val Tyr Arg Ile Glu Ala Gly Ala Gln Asp
            2100                2105                2110        
Arg Phe Leu Ile His Leu Val Thr Gly Val Ile Arg Val Gly Asn Ala
        2115                2120                2125            
Thr Ile Asp Arg Glu Glu Gln Glu Ser Tyr Arg Leu Thr Val Val Ala
    2130                2135                2140                
Thr Asp Arg Gly Thr Val Pro Leu Ser Gly Thr Ala Ile Val Thr Ile
2145                2150                2155                2160
Leu Ile Asp Asp Ile Asn Asp Ser Arg Pro Glu Phe Leu Asn Pro Ile
                2165                2170                2175    
Gln Thr Val Ser Val Leu Glu Ser Ala Glu Pro Gly Thr Val Ile Ala
            2180                2185                2190        
Asn Ile Thr Ala Ile Asp His Asp Leu Asn Pro Lys Leu Glu Tyr His
        2195                2200                2205            
Ile Val Gly Ile Val Ala Lys Asp Asp Thr Asp Arg Leu Val Pro Asn
    2210                2215                2220                
Gln Glu Asp Ala Phe Ala Val Asn Ile Asn Thr Gly Ser Val Met Val
2225                2230                2235                2240
Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr Glu Val Thr Leu
                2245                2250                2255    
Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val Ser Val
            2260                2265                2270        
Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val Asn Asp Asn Thr
        2275                2280                2285            
Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met Glu Arg Ile Leu
    2290                2295                2300                
Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val Ala Ala Val Asp
2305                2310                2315                2320
Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr Leu Leu Asp Leu
                2325                2330                2335    
Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser Ala Gly Lys Val
            2340                2345                2350        
Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His Trp Leu Asn Phe
        2355                2360                2365            
Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg Ala Ala Glu Ile
    2370                2375                2380                
Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn Asn Pro Ile Phe
2385                2390                2395                2400
Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp Val Pro Val Gly
                2405                2410                2415    
Thr Ile Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Ser Gly Asn Phe
            2420                2425                2430        
Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser Lys Phe Ala Ile
        2435                2440                2445            
Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser Leu Asp Arg Glu
    2450                2455                2460                
Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys Asp Asn Pro Gly
2465                2470                2475                2480
Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln Val Val Ile Gln
                2485                2490                2495    
Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser Lys Pro Gln Phe
            2500                2505                2510        
Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr Ser Val Ile Thr
        2515                2520                2525            
Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly Glu Leu Thr Tyr
    2530                2535                2540                
Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val Asp Met Asp Ser
2545                2550                2555                2560
Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr Glu Lys Phe Ser
                2565                2570                2575    
Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro Leu Trp Gly Thr
            2580                2585                2590        
Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp Asn Arg Pro Val
        2595                2600                2605            
Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile Arg Glu Glu Ile
    2610                2615                2620                
Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr Asp Lys Asp Glu
2625                2630                2635                2640
Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe Leu Lys Thr Ala Gly Asn
                2645                2650                2655    
Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser Gly Leu Ile Gln
            2660                2665                2670        
Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val Tyr Ser Leu Ile
        2675                2680                2685            
Leu Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr Glu Thr Met Gln
    2690                2695                2700                
Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn Glu Pro Leu Phe
2705                2710                2715                2720
Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu Leu Thr Val Pro
                2725                2730                2735    
Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val Thr Gly Ala Val
            2740                2745                2750        
Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr Phe Ile Ala Ala
        2755                2760                2765            
Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp Gly Cys Leu Leu
    2770                2775                2780                
Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile Phe Ser Phe Ile
2785                2790                2795                2800
Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro Arg Gly Pro Ser
                2805                2810                2815    
Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln Glu Val Arg Val
            2820                2825                2830        
Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe Thr Lys Ala Glu
        2835                2840                2845            
Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly Ser Glu Leu Ile
    2850                2855                2860                
Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn Ser Leu Val Phe
2865                2870                2875                2880
Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu Ala Asn Asp Ser
                2885                2890                2895    
Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met Asp Gly Ile Leu
            2900                2905                2910        
Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly Tyr Phe Val Val
        2915                2920                2925            
Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp Thr Ala Ile Ile
    2930                2935                2940                
Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lys Ile Val Ile Asn
2945                2950                2955                2960
Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Phe Ile His Leu
                2965                2970                2975    
Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp Asn Val Gln Phe
            2980                2985                2990        
His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln Thr Glu Leu Leu
        2995                3000                3005            
Ile His Val Val Asn Arg Asp Thr Asn Arg Ile Leu Asp Val Asp Arg
    3010                3015                3020                
Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu Arg Asn Leu Phe
3025                3030                3035                3040
Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile Ser Val Arg Leu
                3045                3050                3055    
Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile Val Leu Ala Ile
            3060                3065                3070        
Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met Asn Trp Tyr Tyr
        3075                3080                3085            
Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val Ala Gly Ser Ala
    3090                3095                3100                
Gly Asn Arg Gly Phe Ile Asp Ile Met Asp Met Pro Asn Thr Asn Lys
3105                3110                3115                3120
Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp Pro Phe Cys Arg
                3125                3130                3135    
Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp Leu Pro Glu
            3140                3145                3150        
Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr Arg Thr His
        3155                3160                3165            
Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp Asp Asp Arg
    3170                3175                3180                
Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala Lys Leu Gly
3185                3190                3195                3200
Gln Ile Ile Arg Glu Gly Pro Ile Lys Gly Ser Leu Leu Lys Val Val
                3205                3210                3215    
Leu Glu Asp Tyr Leu Arg Leu Lys Lys Leu Phe Ala Gln Arg Met Val
            3220                3225                3230        
Gln Lys Ala Ser Ser Cys His Ser Ser Ile Ser Glu Leu Ile Gln Thr
        3235                3240                3245            
Glu Leu Asp Glu Glu Pro Gly Asp His Ser Pro Gly Gln Gly Ser Leu
    3250                3255                3260                
Arg Phe Arg His Lys Pro Pro Val Glu Leu Lys Gly Pro Asp Gly Ile
3265                3270                3275                3280
His Val Val His Gly Ser Thr Gly Thr Leu Leu Ala Thr Asp Leu Asn
                3285                3290                3295    
Ser Leu Pro Glu Glu Asp Gln Lys Gly Leu Gly Arg Ser Leu Glu Thr
            3300                3305                3310        
Leu Thr Ala Ala Glu Ala Thr Ala Phe Glu Arg Asn Ala Arg Thr Glu
        3315                3320                3325            
Ser Ala Lys Ser Thr Pro Leu His Lys Leu Arg Asp Val Ile Met Glu
    3330                3335                3340                
Thr Pro Leu Glu Ile Thr Glu Leu
3345                3350        


<210> 5812
<211> 426
<212> PRT
<213> Homo sapiens

<400> 5812
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys
 1               5                  10                  15      
Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg
            20                  25                  30          
Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg
        35                  40                  45              
Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu
    50                  55                  60                  
Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg
65                  70                  75                  80  
Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp
                85                  90                  95      
Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys
            100                 105                 110         
Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro
        115                 120                 125             
Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser
    130                 135                 140                 
Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu
145                 150                 155                 160 
Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg
                165                 170                 175     
Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln
            180                 185                 190         
Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys
        195                 200                 205             
Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu
    210                 215                 220                 
Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys
225                 230                 235                 240 
Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys
                245                 250                 255     
Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys
            260                 265                 270         
Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly
        275                 280                 285             
Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu
    290                 295                 300                 
Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp
305                 310                 315                 320 
Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser
                325                 330                 335     
Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr
            340                 345                 350         
Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu
        355                 360                 365             
Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys
    370                 375                 380                 
Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Ser Val Leu Trp
385                 390                 395                 400 
Asp Thr Pro Gly Thr Gly Val Ser Ser Ser Gln Trp Ser Thr Ser Pro
                405                 410                 415     
Lys Pro Arg Ser Cys Thr Arg Arg Gly Ser
            420                 425     


<210> 5813
<211> 852
<212> PRT
<213> Homo sapiens

<400> 5813
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys
 1               5                  10                  15      
Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg
            20                  25                  30          
Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg
        35                  40                  45              
Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu
    50                  55                  60                  
Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg
65                  70                  75                  80  
Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp
                85                  90                  95      
Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys
            100                 105                 110         
Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro
        115                 120                 125             
Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser
    130                 135                 140                 
Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu
145                 150                 155                 160 
Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg
                165                 170                 175     
Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln
            180                 185                 190         
Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys
        195                 200                 205             
Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu
    210                 215                 220                 
Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys
225                 230                 235                 240 
Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys
                245                 250                 255     
Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys
            260                 265                 270         
Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly
        275                 280                 285             
Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu
    290                 295                 300                 
Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp
305                 310                 315                 320 
Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser
                325                 330                 335     
Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr
            340                 345                 350         
Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu
        355                 360                 365             
Ser Cys Lys Cys Pro Val Gly Tyr Thr Gly Asp Arg Cys Gln Gln Phe
    370                 375                 380                 
Ala Met Val Asn Phe Ser Lys His Leu Gly Phe Glu Leu Lys Glu Ala
385                 390                 395                 400 
Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val
                405                 410                 415     
Ala Leu Leu Val Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr
            420                 425                 430         
Lys Lys Gln Arg Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys
        435                 440                 445             
Pro Ala His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg
    450                 455                 460                 
Leu Asp Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val
465                 470                 475                 480 
Pro Ala Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser
                485                 490                 495     
Gly Ser His Ser Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro
            500                 505                 510         
Thr Ser Ser His Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser
        515                 520                 525             
Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val
    530                 535                 540                 
Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg
545                 550                 555                 560 
Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro
                565                 570                 575     
Pro Tyr His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu
            580                 585                 590         
Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp
        595                 600                 605             
Phe His Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser
    610                 615                 620                 
Pro Asn Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser
625                 630                 635                 640 
Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro
                645                 650                 655     
Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met
            660                 665                 670         
Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro
        675                 680                 685             
Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala
    690                 695                 700                 
Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu
705                 710                 715                 720 
Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg
                725                 730                 735     
Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly
            740                 745                 750         
Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser
        755                 760                 765             
Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp
    770                 775                 780                 
Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu
785                 790                 795                 800 
Arg Gly Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro
                805                 810                 815     
Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg
            820                 825                 830         
Ala Ser Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp
        835                 840                 845             
Ser Ala Pro Leu
    850         


<210> 5814
<211> 850
<212> PRT
<213> Homo sapiens

<400> 5814
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys
 1               5                  10                  15      
Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg
            20                  25                  30          
Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg
        35                  40                  45              
Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu
    50                  55                  60                  
Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg
65                  70                  75                  80  
Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp
                85                  90                  95      
Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys
            100                 105                 110         
Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro
        115                 120                 125             
Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser
    130                 135                 140                 
Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu
145                 150                 155                 160 
Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg
                165                 170                 175     
Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln
            180                 185                 190         
Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys
        195                 200                 205             
Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu
    210                 215                 220                 
Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys
225                 230                 235                 240 
Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys
                245                 250                 255     
Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys
            260                 265                 270         
Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly
        275                 280                 285             
Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu
    290                 295                 300                 
Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp
305                 310                 315                 320 
Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser
                325                 330                 335     
Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr
            340                 345                 350         
Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu
        355                 360                 365             
Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys
    370                 375                 380                 
Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys Ala Glu Glu
385                 390                 395                 400 
Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val Ala Leu
                405                 410                 415     
Leu Val Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr Lys Lys
            420                 425                 430         
Gln Arg Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys Pro Ala
        435                 440                 445             
His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg Leu Asp
    450                 455                 460                 
Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala
465                 470                 475                 480 
Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser
                485                 490                 495     
His Ser Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro Thr Ser
            500                 505                 510         
Ser His Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser Glu Ser
        515                 520                 525             
Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val Gly Thr
    530                 535                 540                 
Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg Arg Ala
545                 550                 555                 560 
Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr
                565                 570                 575     
His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu Arg Tyr
            580                 585                 590         
Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp Phe His
        595                 600                 605             
Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser Pro Asn
    610                 615                 620                 
Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg
625                 630                 635                 640 
Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro Gly Pro
                645                 650                 655     
Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met Gln Arg
            660                 665                 670         
Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg
        675                 680                 685             
Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro
    690                 695                 700                 
Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala
705                 710                 715                 720 
Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr
                725                 730                 735     
Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala
            740                 745                 750         
Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly
        755                 760                 765             
Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala
    770                 775                 780                 
Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly
785                 790                 795                 800 
Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala
                805                 810                 815     
Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg Ala Ser
            820                 825                 830         
Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala
        835                 840                 845             
Pro Leu
    850 


<210> 5815
<211> 422
<212> PRT
<213> Homo sapiens

<400> 5815
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys
 1               5                  10                  15      
Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg
            20                  25                  30          
Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg
        35                  40                  45              
Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu
    50                  55                  60                  
Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg
65                  70                  75                  80  
Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp
                85                  90                  95      
Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys
            100                 105                 110         
Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro
        115                 120                 125             
Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser
    130                 135                 140                 
Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu
145                 150                 155                 160 
Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg
                165                 170                 175     
Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln
            180                 185                 190         
Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys
        195                 200                 205             
Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu
    210                 215                 220                 
Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys
225                 230                 235                 240 
Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys
                245                 250                 255     
Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys
            260                 265                 270         
Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly
        275                 280                 285             
Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu
    290                 295                 300                 
Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp
305                 310                 315                 320 
Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser
                325                 330                 335     
Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr
            340                 345                 350         
Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu
        355                 360                 365             
Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys
    370                 375                 380                 
Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Ser Val Leu Trp
385                 390                 395                 400 
Asp Thr Pro Gly Thr Gly Val Ser Ser Ser Gln Trp Ser Thr Ser Pro
                405                 410                 415     
Ser Thr Leu Asp Leu Asn
            420         


<210> 5816
<211> 844
<212> PRT
<213> Homo sapiens

<400> 5816
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys
 1               5                  10                  15      
Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg
            20                  25                  30          
Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg
        35                  40                  45              
Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu
    50                  55                  60                  
Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg
65                  70                  75                  80  
Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp
                85                  90                  95      
Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys
            100                 105                 110         
Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro
        115                 120                 125             
Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser
    130                 135                 140                 
Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu
145                 150                 155                 160 
Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg
                165                 170                 175     
Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln
            180                 185                 190         
Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys
        195                 200                 205             
Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu
    210                 215                 220                 
Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys
225                 230                 235                 240 
Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys
                245                 250                 255     
Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys
            260                 265                 270         
Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly
        275                 280                 285             
Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu
    290                 295                 300                 
Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp
305                 310                 315                 320 
Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser
                325                 330                 335     
Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr
            340                 345                 350         
Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu
        355                 360                 365             
Ser Cys Lys Cys Pro Val Gly Tyr Thr Gly Asp Arg Cys Gln Gln Phe
    370                 375                 380                 
Ala Met Val Asn Phe Ser Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val
385                 390                 395                 400 
Leu Thr Ile Thr Gly Ile Cys Val Ala Leu Leu Val Val Gly Ile Val
                405                 410                 415     
Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His
            420                 425                 430         
Asn His Leu Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu
        435                 440                 445             
Ala Asn Gly Pro Ser His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met
    450                 455                 460                 
Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala Thr Asp His Val Ile Arg
465                 470                 475                 480 
Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser
                485                 490                 495     
His His Cys Ser Thr Ala Thr Pro Thr Ser Ser His Arg His Glu Ser
            500                 505                 510         
His Thr Trp Ser Leu Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln
        515                 520                 525             
Ser Gly Ile Met Leu Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro
    530                 535                 540                 
Ala Cys Val Glu Ala Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu
545                 550                 555                 560 
Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser
                565                 570                 575     
Leu Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr
            580                 585                 590         
Pro Ala Arg Leu Ser Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln
        595                 600                 605             
Val Pro Thr Phe Glu Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser
    610                 615                 620                 
Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro
625                 630                 635                 640 
Leu Leu Arg His Pro Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro
                645                 650                 655     
Gly Pro Gly Pro Gly Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr
            660                 665                 670         
Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly
        675                 680                 685             
Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp
    690                 695                 700                 
Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg
705                 710                 715                 720 
Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg
                725                 730                 735     
Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala
            740                 745                 750         
Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala
        755                 760                 765             
Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala
    770                 775                 780                 
Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg
785                 790                 795                 800 
Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr
                805                 810                 815     
Ser Leu Asp Ser His Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly
            820                 825                 830         
Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala Pro Leu
        835                 840                 


<210> 5817
<211> 858
<212> PRT
<213> Homo sapiens

<400> 5817
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys
 1               5                  10                  15      
Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg
            20                  25                  30          
Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg
        35                  40                  45              
Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu
    50                  55                  60                  
Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg
65                  70                  75                  80  
Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp
                85                  90                  95      
Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys
            100                 105                 110         
Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro
        115                 120                 125             
Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser
    130                 135                 140                 
Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu
145                 150                 155                 160 
Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg
                165                 170                 175     
Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln
            180                 185                 190         
Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys
        195                 200                 205             
Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu
    210                 215                 220                 
Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys
225                 230                 235                 240 
Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys
                245                 250                 255     
Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys
            260                 265                 270         
Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly
        275                 280                 285             
Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu
    290                 295                 300                 
Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp
305                 310                 315                 320 
Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser
                325                 330                 335     
Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr
            340                 345                 350         
Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu
        355                 360                 365             
Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys
    370                 375                 380                 
Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys His Leu Gly
385                 390                 395                 400 
Phe Glu Leu Lys Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr
                405                 410                 415     
Ile Thr Gly Ile Cys Val Ala Leu Leu Val Val Gly Ile Val Cys Val
            420                 425                 430         
Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His Asn His
        435                 440                 445             
Leu Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu Ala Asn
    450                 455                 460                 
Gly Pro Ser His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met Ala Asp
465                 470                 475                 480 
Tyr Ile Ser Lys Asn Val Pro Ala Thr Asp His Val Ile Arg Arg Glu
                485                 490                 495     
Thr Glu Thr Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser His His
            500                 505                 510         
Cys Ser Thr Ala Thr Pro Thr Ser Ser His Arg His Glu Ser His Thr
        515                 520                 525             
Trp Ser Leu Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly
    530                 535                 540                 
Ile Met Leu Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys
545                 550                 555                 560 
Val Glu Ala Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg
                565                 570                 575     
Arg Arg Ala Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser Leu Arg
            580                 585                 590         
Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala
        595                 600                 605             
Arg Leu Ser Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln Val Pro
    610                 615                 620                 
Thr Phe Glu Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser Leu Pro
625                 630                 635                 640 
Pro Ala Ala Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu
                645                 650                 655     
Arg His Pro Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro
            660                 665                 670         
Gly Pro Gly Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro
        675                 680                 685             
Ala Ala Gly Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser
    690                 695                 700                 
Leu Gly Ser Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu
705                 710                 715                 720 
Tyr Glu Thr Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg
                725                 730                 735     
Ala Arg Gly Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg
            740                 745                 750         
Arg Ser Arg Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg
        755                 760                 765             
Asp Ser Leu Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala
    770                 775                 780                 
Ser Asp Asp Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser
785                 790                 795                 800 
Thr Pro Phe Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg Ser Asp
                805                 810                 815     
Ser Pro Pro Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu
            820                 825                 830         
Asp Ser His Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly Pro Pro
        835                 840                 845             
Pro Arg Ala Lys Gln Asp Ser Ala Pro Leu
    850                 855             


<210> 5818
<211> 847
<212> PRT
<213> Homo sapiens

<400> 5818
Met Leu Phe Lys Leu Leu Gln Arg Gln Thr Tyr Thr Cys Leu Ser His
 1               5                  10                  15      
Arg Tyr Gly Leu Tyr Val Cys Phe Leu Gly Val Val Val Thr Ile Val
            20                  25                  30          
Ser Ala Phe Gln Phe Gly Glu Val Val Leu Glu Trp Ser Arg Asp Gln
        35                  40                  45              
Tyr His Val Leu Phe Asp Ser Tyr Arg Asp Asn Ile Ala Gly Lys Ser
    50                  55                  60                  
Phe Gln Asn Arg Leu Cys Leu Pro Met Pro Ile Asp Val Val Tyr Thr
65                  70                  75                  80  
Trp Val Asn Gly Thr Asp Leu Glu Leu Leu Lys Glu Leu Gln Gln Val
                85                  90                  95      
Arg Glu Gln Met Glu Glu Glu Gln Lys Ala Met Arg Glu Ile Leu Gly
            100                 105                 110         
Lys Asn Thr Thr Glu Pro Thr Lys Lys Ser Glu Lys Gln Leu Glu Cys
        115                 120                 125             
Leu Leu Thr His Cys Ile Lys Val Pro Met Leu Val Leu Asp Pro Ala
    130                 135                 140                 
Leu Pro Ala Asn Ile Thr Leu Lys Asp Leu Pro Ser Leu Tyr Pro Ser
145                 150                 155                 160 
Phe His Ser Ala Ser Asp Ile Phe Asn Val Ala Lys Pro Lys Asn Pro
                165                 170                 175     
Ser Thr Asn Val Ser Val Val Val Phe Asp Ser Thr Lys Asp Val Glu
            180                 185                 190         
Asp Ala His Ser Gly Leu Leu Lys Gly Asn Ser Arg Gln Thr Val Trp
        195                 200                 205             
Arg Gly Tyr Leu Thr Thr Asp Lys Glu Val Pro Gly Leu Val Leu Met
    210                 215                 220                 
Gln Asp Leu Ala Phe Leu Ser Gly Phe Pro Pro Thr Phe Lys Glu Thr
225                 230                 235                 240 
Asn Gln Leu Lys Thr Lys Leu Pro Glu Asn Leu Ser Ser Lys Val Lys
                245                 250                 255     
Leu Leu Gln Leu Tyr Ser Glu Ala Ser Val Ala Leu Leu Lys Leu Asn
            260                 265                 270         
Asn Pro Lys Asp Phe Gln Glu Leu Asn Lys Gln Thr Lys Lys Asn Met
        275                 280                 285             
Thr Ile Asp Gly Lys Glu Leu Thr Ile Ser Pro Ala Tyr Leu Leu Trp
    290                 295                 300                 
Asp Leu Ser Ala Ile Ser Gln Ser Lys Gln Asp Glu Asp Ile Ser Ala
305                 310                 315                 320 
Ser Arg Phe Glu Asp Asn Glu Glu Leu Arg Tyr Ser Leu Arg Ser Ile
                325                 330                 335     
Glu Arg His Ala Pro Trp Val Arg Asn Ile Phe Ile Val Thr Asn Gly
            340                 345                 350         
Gln Ile Pro Ser Trp Leu Asn Leu Asp Asn Pro Arg Val Thr Ile Val
        355                 360                 365             
Thr His Gln Asp Val Phe Arg Asn Leu Ser His Leu Pro Thr Phe Ser
    370                 375                 380                 
Ser Pro Ala Ile Glu Ser His Ile His Arg Ile Glu Gly Leu Ser Gln
385                 390                 395                 400 
Lys Phe Ile Tyr Leu Asn Asp Asp Val Met Phe Gly Lys Asp Val Trp
                405                 410                 415     
Pro Asp Asp Phe Tyr Ser His Ser Lys Gly Gln Lys Val Tyr Leu Thr
            420                 425                 430         
Trp Pro Val Pro Asn Cys Ala Glu Gly Cys Pro Gly Ser Trp Ile Lys
        435                 440                 445             
Asp Gly Tyr Cys Asp Lys Ala Cys Asn Asn Ser Ala Cys Asp Trp Asp
    450                 455                 460                 
Gly Gly Asp Cys Ser Gly Asn Ser Gly Gly Ser Arg Tyr Ile Ala Gly
465                 470                 475                 480 
Gly Gly Gly Thr Gly Ser Ile Gly Val Gly Gln Pro Trp Gln Phe Gly
                485                 490                 495     
Gly Gly Ile Asn Ser Val Ser Tyr Cys Asn Gln Gly Cys Ala Asn Ser
            500                 505                 510         
Trp Leu Ala Asp Lys Phe Cys Asp Gln Ala Cys Asn Val Leu Ser Cys
        515                 520                 525             
Gly Phe Asp Ala Gly Asp Cys Gly Gln Asp His Phe His Glu Leu Tyr
    530                 535                 540                 
Lys Val Ile Leu Leu Pro Asn Gln Thr His Tyr Ile Ile Pro Lys Gly
545                 550                 555                 560 
Glu Cys Leu Pro Tyr Phe Ser Phe Ala Glu Val Ala Lys Arg Gly Val
                565                 570                 575     
Glu Gly Ala Tyr Ser Asp Asn Pro Ile Ile Arg His Ala Ser Ile Ala
            580                 585                 590         
Asn Lys Trp Lys Thr Ile His Leu Ile Met His Ser Gly Met Asn Ala
        595                 600                 605             
Thr Thr Ile His Phe Asn Leu Thr Phe Gln Asn Thr Asn Asp Glu Glu
    610                 615                 620                 
Phe Lys Met Gln Ile Thr Val Glu Val Asp Thr Arg Glu Gly Pro Lys
625                 630                 635                 640 
Leu Asn Ser Thr Ala Gln Lys Gly Tyr Glu Asn Leu Val Ser Pro Ile
                645                 650                 655     
Thr Leu Leu Pro Glu Ala Glu Ile Leu Phe Glu Asp Ile Pro Lys Glu
            660                 665                 670         
Lys Arg Phe Pro Lys Phe Lys Arg His Asp Val Asn Ser Thr Arg Arg
        675                 680                 685             
Ala Gln Glu Glu Val Lys Ile Pro Leu Val Asn Ile Ser Leu Leu Pro
    690                 695                 700                 
Lys Asp Ala Gln Leu Ser Leu Asn Thr Leu Asp Leu Gln Leu Glu His
705                 710                 715                 720 
Gly Asp Ile Thr Leu Lys Gly Tyr Asn Leu Ser Lys Ser Ala Leu Leu
                725                 730                 735     
Arg Ser Phe Leu Met Asn Ser Gln His Ala Lys Ile Lys Asn Gln Ala
            740                 745                 750         
Ile Ile Thr Asp Glu Thr Asn Asp Ser Leu Val Ala Pro Gln Glu Lys
        755                 760                 765             
Gln Val His Lys Ser Ile Leu Pro Asn Ser Leu Gly Val Ser Glu Arg
    770                 775                 780                 
Leu Gln Arg Leu Thr Phe Pro Ala Val Ser Val Lys Val Asn Gly His
785                 790                 795                 800 
Asp Gln Gly Gln Asn Pro Pro Leu Asp Leu Glu Thr Thr Ala Arg Phe
                805                 810                 815     
Arg Val Glu Thr His Thr Gln Lys Thr Ile Gly Gly Asn Val Thr Lys
            820                 825                 830         
Glu Lys Pro Pro Ser Leu Ile Val Pro Leu Glu Ser Gln Met Thr
        835                 840                 845         


<210> 5819
<211> 1256
<212> PRT
<213> Homo sapiens

<400> 5819
Met Leu Phe Lys Leu Leu Gln Arg Gln Thr Tyr Thr Cys Leu Ser His
 1               5                  10                  15      
Arg Tyr Gly Leu Tyr Val Cys Phe Leu Gly Val Val Val Thr Ile Val
            20                  25                  30          
Ser Ala Phe Gln Phe Gly Glu Val Val Leu Glu Trp Ser Arg Asp Gln
        35                  40                  45              
Tyr His Val Leu Phe Asp Ser Tyr Arg Asp Asn Ile Ala Gly Lys Ser
    50                  55                  60                  
Phe Gln Asn Arg Leu Cys Leu Pro Met Pro Ile Asp Val Val Tyr Thr
65                  70                  75                  80  
Trp Val Asn Gly Thr Asp Leu Glu Leu Leu Lys Glu Leu Gln Gln Val
                85                  90                  95      
Arg Glu Gln Met Glu Glu Glu Gln Lys Ala Met Arg Glu Ile Leu Gly
            100                 105                 110         
Lys Asn Thr Thr Glu Pro Thr Lys Lys Ser Glu Lys Gln Leu Glu Cys
        115                 120                 125             
Leu Leu Thr His Cys Ile Lys Val Pro Met Leu Val Leu Asp Pro Ala
    130                 135                 140                 
Leu Pro Ala Asn Ile Thr Leu Lys Asp Leu Pro Ser Leu Tyr Pro Ser
145                 150                 155                 160 
Phe His Ser Ala Ser Asp Ile Phe Asn Val Ala Lys Pro Lys Asn Pro
                165                 170                 175     
Ser Thr Asn Val Ser Val Val Val Phe Asp Ser Thr Lys Asp Val Glu
            180                 185                 190         
Asp Ala His Ser Gly Leu Leu Lys Gly Asn Ser Arg Gln Thr Val Trp
        195                 200                 205             
Arg Gly Tyr Leu Thr Thr Asp Lys Glu Val Pro Gly Leu Val Leu Met
    210                 215                 220                 
Gln Asp Leu Ala Phe Leu Ser Gly Phe Pro Pro Thr Phe Lys Glu Thr
225                 230                 235                 240 
Asn Gln Leu Lys Thr Lys Leu Pro Glu Asn Leu Ser Ser Lys Val Lys
                245                 250                 255     
Leu Leu Gln Leu Tyr Ser Glu Ala Ser Val Ala Leu Leu Lys Leu Asn
            260                 265                 270         
Asn Pro Lys Asp Phe Gln Glu Leu Asn Lys Gln Thr Lys Lys Asn Met
        275                 280                 285             
Thr Ile Asp Gly Lys Glu Leu Thr Ile Ser Pro Ala Tyr Leu Leu Trp
    290                 295                 300                 
Asp Leu Ser Ala Ile Ser Gln Ser Lys Gln Asp Glu Asp Ile Ser Ala
305                 310                 315                 320 
Ser Arg Phe Glu Asp Asn Glu Glu Leu Arg Tyr Ser Leu Arg Ser Ile
                325                 330                 335     
Glu Arg His Ala Pro Trp Val Arg Asn Ile Phe Ile Val Thr Asn Gly
            340                 345                 350         
Gln Ile Pro Ser Trp Leu Asn Leu Asp Asn Pro Arg Val Thr Ile Val
        355                 360                 365             
Thr His Gln Asp Val Phe Arg Asn Leu Ser His Leu Pro Thr Phe Ser
    370                 375                 380                 
Ser Pro Ala Ile Glu Ser His Ile His Arg Ile Glu Gly Leu Ser Gln
385                 390                 395                 400 
Lys Phe Ile Tyr Leu Asn Asp Asp Val Met Phe Gly Lys Asp Val Trp
                405                 410                 415     
Pro Asp Asp Phe Tyr Ser His Ser Lys Gly Gln Lys Val Tyr Leu Thr
            420                 425                 430         
Trp Pro Val Pro Asn Cys Ala Glu Gly Cys Pro Gly Ser Trp Ile Lys
        435                 440                 445             
Asp Gly Tyr Cys Asp Lys Ala Cys Asn Asn Ser Ala Cys Asp Trp Asp
    450                 455                 460                 
Gly Gly Asp Cys Ser Gly Asn Ser Gly Gly Ser Arg Tyr Ile Ala Gly
465                 470                 475                 480 
Gly Gly Gly Thr Gly Ser Ile Gly Val Gly Gln Pro Trp Gln Phe Gly
                485                 490                 495     
Gly Gly Ile Asn Ser Val Ser Tyr Cys Asn Gln Gly Cys Ala Asn Ser
            500                 505                 510         
Trp Leu Ala Asp Lys Phe Cys Asp Gln Ala Cys Asn Val Leu Ser Cys
        515                 520                 525             
Gly Phe Asp Ala Gly Asp Cys Gly Gln Asp His Phe His Glu Leu Tyr
    530                 535                 540                 
Lys Val Ile Leu Leu Pro Asn Gln Thr His Tyr Ile Ile Pro Lys Gly
545                 550                 555                 560 
Glu Cys Leu Pro Tyr Phe Ser Phe Ala Glu Val Ala Lys Arg Gly Val
                565                 570                 575     
Glu Gly Ala Tyr Ser Asp Asn Pro Ile Ile Arg His Ala Ser Ile Ala
            580                 585                 590         
Asn Lys Trp Lys Thr Ile His Leu Ile Met His Ser Gly Met Asn Ala
        595                 600                 605             
Thr Thr Ile His Phe Asn Leu Thr Phe Gln Asn Thr Asn Asp Glu Glu
    610                 615                 620                 
Phe Lys Met Gln Ile Thr Val Glu Val Asp Thr Arg Glu Gly Pro Lys
625                 630                 635                 640 
Leu Asn Ser Thr Ala Gln Lys Gly Tyr Glu Asn Leu Val Ser Pro Ile
                645                 650                 655     
Thr Leu Leu Pro Glu Ala Glu Ile Leu Phe Glu Asp Ile Pro Lys Glu
            660                 665                 670         
Lys Arg Phe Pro Lys Phe Lys Arg His Asp Val Asn Ser Thr Arg Arg
        675                 680                 685             
Ala Gln Glu Glu Val Lys Ile Pro Leu Val Asn Ile Ser Leu Leu Pro
    690                 695                 700                 
Lys Asp Ala Gln Leu Ser Leu Asn Thr Leu Asp Leu Gln Leu Glu His
705                 710                 715                 720 
Gly Asp Ile Thr Leu Lys Gly Tyr Asn Leu Ser Lys Ser Ala Leu Leu
                725                 730                 735     
Arg Ser Phe Leu Met Asn Ser Gln His Ala Lys Ile Lys Asn Gln Ala
            740                 745                 750         
Ile Ile Thr Asp Glu Thr Asn Asp Ser Leu Val Ala Pro Gln Glu Lys
        755                 760                 765             
Gln Val His Lys Ser Ile Leu Pro Asn Ser Leu Gly Val Ser Glu Arg
    770                 775                 780                 
Leu Gln Arg Leu Thr Phe Pro Ala Val Ser Val Lys Val Asn Gly His
785                 790                 795                 800 
Asp Gln Gly Gln Asn Pro Pro Leu Asp Leu Glu Thr Thr Ala Arg Phe
                805                 810                 815     
Arg Val Glu Thr His Thr Gln Lys Thr Ile Gly Gly Asn Val Thr Lys
            820                 825                 830         
Glu Lys Pro Pro Ser Leu Ile Val Pro Leu Glu Ser Gln Met Thr Lys
        835                 840                 845             
Glu Lys Lys Ile Thr Gly Lys Glu Lys Glu Asn Ser Arg Met Glu Glu
    850                 855                 860                 
Asn Ala Glu Asn His Ile Gly Val Thr Glu Val Leu Leu Gly Arg Lys
865                 870                 875                 880 
Leu Gln His Tyr Thr Asp Ser Tyr Leu Gly Phe Leu Pro Trp Glu Lys
                885                 890                 895     
Lys Lys Tyr Phe Gln Asp Leu Leu Asp Glu Glu Glu Ser Leu Lys Thr
            900                 905                 910         
Gln Leu Ala Tyr Phe Thr Asp Ser Lys Asn Thr Gly Arg Gln Leu Lys
        915                 920                 925             
Asp Thr Phe Ala Asp Ser Leu Arg Tyr Val Asn Lys Ile Leu Asn Ser
    930                 935                 940                 
Lys Phe Gly Phe Thr Ser Arg Lys Val Pro Ala His Met Pro His Met
945                 950                 955                 960 
Ile Asp Arg Ile Val Met Gln Glu Leu Gln Asp Met Phe Pro Glu Glu
                965                 970                 975     
Phe Asp Lys Thr Ser Phe His Lys Val Arg His Ser Glu Asp Met Gln
            980                 985                 990         
Phe Ala Phe Ser Tyr Phe Tyr Tyr Leu Met Ser Ala Val Gln Pro Leu
        995                 1000                1005            
Asn Ile Ser Gln Val Phe Asp Glu Val Asp Thr Asp Gln Ser Gly Val
    1010                1015                1020                
Leu Ser Asp Arg Glu Ile Arg Thr Leu Ala Thr Arg Ile His Glu Leu
1025                1030                1035                1040
Pro Leu Ser Leu Gln Asp Leu Thr Gly Leu Glu His Met Leu Ile Asn
                1045                1050                1055    
Cys Ser Lys Met Leu Pro Ala Asp Ile Thr Gln Leu Asn Asn Ile Pro
            1060                1065                1070        
Pro Thr Gln Glu Ser Tyr Tyr Asp Pro Asn Leu Pro Pro Val Thr Lys
        1075                1080                1085            
Ser Leu Val Thr Asn Cys Lys Pro Val Thr Asp Lys Ile His Lys Ala
    1090                1095                1100                
Tyr Lys Asp Lys Asn Lys Tyr Arg Phe Glu Ile Met Gly Glu Glu Glu
1105                1110                1115                1120
Ile Ala Phe Lys Met Ile Arg Thr Asn Val Ser His Val Val Gly Gln
                1125                1130                1135    
Leu Asp Asp Ile Arg Lys Asn Pro Arg Lys Phe Val Cys Leu Asn Asp
            1140                1145                1150        
Asn Ile Asp His Asn His Lys Asp Ala Gln Thr Val Lys Ala Val Leu
        1155                1160                1165            
Arg Asp Phe Tyr Glu Ser Met Phe Pro Ile Pro Ser Gln Phe Glu Leu
    1170                1175                1180                
Pro Arg Glu Tyr Arg Asn Arg Phe Leu His Met His Glu Leu Gln Glu
1185                1190                1195                1200
Trp Arg Ala Tyr Arg Asp Lys Leu Lys Phe Trp Thr His Cys Val Leu
                1205                1210                1215    
Ala Thr Leu Ile Met Phe Thr Ile Phe Ser Phe Phe Ala Glu Gln Leu
            1220                1225                1230        
Ile Ala Leu Lys Arg Lys Ile Phe Pro Arg Arg Arg Ile His Lys Glu
        1235                1240                1245            
Ala Ser Pro Asn Arg Ile Arg Val
    1250                1255    


<210> 5820
<211> 255
<212> PRT
<213> Homo sapiens

<400> 5820
Met Lys Ala Leu Leu Ala Leu Pro Leu Leu Leu Leu Leu Ser Thr Pro
 1               5                  10                  15      
Pro Cys Ala Pro Gln Val Ser Gly Ile Arg Gly Asp Ala Leu Glu Arg
            20                  25                  30          
Phe Cys Leu Gln Gln Pro Leu Asp Cys Asp Asp Ile Tyr Ala Gln Gly
        35                  40                  45              
Tyr Gln Ser Asp Gly Val Tyr Leu Ile Tyr Pro Ser Gly Pro Ser Val
    50                  55                  60                  
Pro Val Pro Val Phe Cys Asp Met Thr Thr Glu Gly Gly Lys Trp Thr
65                  70                  75                  80  
Val Phe Gln Lys Arg Phe Asn Gly Ser Val Ser Phe Phe Arg Gly Trp
                85                  90                  95      
Asn Asp Tyr Lys Leu Gly Phe Gly Arg Ala Asp Gly Glu Tyr Trp Leu
            100                 105                 110         
Gly Leu Gln Asn Met His Leu Leu Thr Leu Lys Gln Lys Tyr Glu Leu
        115                 120                 125             
Arg Val Asp Leu Glu Asp Phe Glu Asn Asn Thr Ala Tyr Ala Lys Tyr
    130                 135                 140                 
Ala Asp Phe Ser Ile Ser Pro Asn Ala Val Ser Ala Glu Glu Asp Gly
145                 150                 155                 160 
Tyr Thr Leu Phe Val Ala Gly Phe Glu Asp Gly Gly Ala Gly Asp Ser
                165                 170                 175     
Leu Ser Tyr His Ser Gly Gln Lys Phe Ser Thr Phe Asp Arg Asp Gln
            180                 185                 190         
Asp Leu Phe Val Gln Asn Cys Ala Ala Leu Ser Ser Gly Ala Phe Trp
        195                 200                 205             
Phe Arg Ser Cys His Phe Ala Asn Leu Asn Gly Phe Tyr Leu Gly Gly
    210                 215                 220                 
Ser His Leu Ser Tyr Ala Asn Gly Ile Asn Trp Ala Gln Trp Lys Gly
225                 230                 235                 240 
Phe Tyr Tyr Ser Leu Lys Arg Thr Glu Met Lys Ile Arg Arg Ala
                245                 250                 255 


<210> 5821
<211> 711
<212> PRT
<213> Homo sapiens

<400> 5821
Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu
 1               5                  10                  15      
Cys Leu Ala Gly Arg Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser
            20                  25                  30          
Gln Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys
        35                  40                  45              
Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln
    50                  55                  60                  
Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp
65                  70                  75                  80  
Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro
                85                  90                  95      
Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr
            100                 105                 110         
Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu
        115                 120                 125             
Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly
    130                 135                 140                 
Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly
145                 150                 155                 160 
Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser
                165                 170                 175     
Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu
            180                 185                 190         
Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro
        195                 200                 205             
Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly
    210                 215                 220                 
Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp
225                 230                 235                 240 
Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg
                245                 250                 255     
Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser
            260                 265                 270         
His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp
        275                 280                 285             
Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro
    290                 295                 300                 
Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe
305                 310                 315                 320 
Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser
                325                 330                 335     
Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg
            340                 345                 350         
Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys
        355                 360                 365             
Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu
    370                 375                 380                 
Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys
385                 390                 395                 400 
Ile Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly
                405                 410                 415     
Gly Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala
            420                 425                 430         
Glu Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val
        435                 440                 445             
Asp Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser
    450                 455                 460                 
Asp Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His
465                 470                 475                 480 
Thr Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu
                485                 490                 495     
Phe Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser
            500                 505                 510         
Cys Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile
        515                 520                 525             
Gly Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg
    530                 535                 540                 
Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly
545                 550                 555                 560 
Asp Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly
                565                 570                 575     
Asn Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala
            580                 585                 590         
Leu Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser
        595                 600                 605             
Cys His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp
    610                 615                 620                 
Lys Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe
625                 630                 635                 640 
Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser
                645                 650                 655     
Glu Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg
            660                 665                 670         
Leu His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val
        675                 680                 685             
Ala Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu
    690                 695                 700                 
Ala Cys Glu Phe Leu Arg Lys
705                 710     


<210> 5822
<211> 556
<212> PRT
<213> Homo sapiens

<400> 5822
Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala
 1               5                  10                  15      
Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln
            20                  25                  30          
Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val
        35                  40                  45              
Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Ser Val Lys
    50                  55                  60                  
Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser
65                  70                  75                  80  
His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu
                85                  90                  95      
Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His
            100                 105                 110         
His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu
        115                 120                 125             
Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser
    130                 135                 140                 
Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu
145                 150                 155                 160 
Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser
                165                 170                 175     
Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser
            180                 185                 190         
Thr Ile Ile Asp Ser Pro Arg Phe Ser His Arg Gly Ile Leu Ile Asp
        195                 200                 205             
Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp
    210                 215                 220                 
Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp
225                 230                 235                 240 
Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn
                245                 250                 255     
Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg
            260                 265                 270         
Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu
        275                 280                 285             
Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp
    290                 295                 300                 
Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly
305                 310                 315                 320 
Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe
                325                 330                 335     
Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly
            340                 345                 350         
Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro Lys Ile Gln
        355                 360                 365             
Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu
    370                 375                 380                 
Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys
385                 390                 395                 400 
Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala
                405                 410                 415     
Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu
            420                 425                 430         
Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro
        435                 440                 445             
Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr
    450                 455                 460                 
Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu
465                 470                 475                 480 
Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr
                485                 490                 495     
Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg
            500                 505                 510         
Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg
        515                 520                 525             
Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln
    530                 535                 540                 
Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met
545                 550                 555     


<210> 5823
<211> 526
<212> PRT
<213> Homo sapiens

<400> 5823
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15      
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30          
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45              
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60                  
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80  
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95      
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110         
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125             
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140                 
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160 
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175     
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190         
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205             
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220                 
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240 
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255     
Met His Met Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe
            260                 265                 270         
Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys
        275                 280                 285             
Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile
    290                 295                 300                 
Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys
305                 310                 315                 320 
Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr
                325                 330                 335     
Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro
            340                 345                 350         
Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser
        355                 360                 365             
Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys
    370                 375                 380                 
Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val
385                 390                 395                 400 
His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys
                405                 410                 415     
Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln
            420                 425                 430         
Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro
        435                 440                 445             
Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu
    450                 455                 460                 
Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys
465                 470                 475                 480 
Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys
                485                 490                 495     
Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala
            500                 505                 510         
Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 525     


<210> 5824
<211> 527
<212> PRT
<213> Homo sapiens

<400> 5824
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15      
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30          
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45              
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60                  
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80  
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95      
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110         
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125             
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140                 
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160 
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175     
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190         
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205             
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220                 
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240 
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255     
Met His Met Gln Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly
            260                 265                 270         
Phe Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala
        275                 280                 285             
Lys Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro
    290                 295                 300                 
Ile Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val
305                 310                 315                 320 
Cys Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys
                325                 330                 335     
Thr Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu
            340                 345                 350         
Pro Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly
        355                 360                 365             
Ser Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val
    370                 375                 380                 
Cys Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr
385                 390                 395                 400 
Val His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys
                405                 410                 415     
Lys Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys
            420                 425                 430         
Gln Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp
        435                 440                 445             
Pro Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val
    450                 455                 460                 
Leu Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu
465                 470                 475                 480 
Lys Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu
                485                 490                 495     
Lys Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala
            500                 505                 510         
Ala Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 525         


<210> 5825
<211> 524
<212> PRT
<213> Homo sapiens

<400> 5825
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15      
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30          
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45              
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60                  
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80  
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95      
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110         
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125             
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140                 
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160 
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175     
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190         
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205             
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220                 
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240 
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255     
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270         
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285             
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300                 
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320 
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335     
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350         
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365             
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380                 
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400 
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415     
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430         
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445             
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460                 
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480 
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495     
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510         
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 


<210> 5826
<211> 999
<212> PRT
<213> Homo sapiens

<400> 5826
Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp
 1               5                  10                  15      
Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr
            20                  25                  30          
Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala
        35                  40                  45              
Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser
    50                  55                  60                  
Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe
65                  70                  75                  80  
Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr
                85                  90                  95      
Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His
            100                 105                 110         
Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp
        115                 120                 125             
Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe
    130                 135                 140                 
Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu
145                 150                 155                 160 
Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val
                165                 170                 175     
Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala
            180                 185                 190         
Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala
        195                 200                 205             
Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr
    210                 215                 220                 
Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys
225                 230                 235                 240 
Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln
                245                 250                 255     
Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly
            260                 265                 270         
Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn
        275                 280                 285             
Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg
    290                 295                 300                 
Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu
305                 310                 315                 320 
Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp
                325                 330                 335     
Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys
            340                 345                 350         
Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln
        355                 360                 365             
Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly
    370                 375                 380                 
Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val
385                 390                 395                 400 
Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala
                405                 410                 415     
Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val
            420                 425                 430         
Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu
        435                 440                 445             
Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His
    450                 455                 460                 
Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys
465                 470                 475                 480 
Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn
                485                 490                 495     
Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly
            500                 505                 510         
Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe
        515                 520                 525             
Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn
    530                 535                 540                 
Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe
545                 550                 555                 560 
Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys
                565                 570                 575     
Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp
            580                 585                 590         
Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro
        595                 600                 605             
Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu
    610                 615                 620                 
Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu
625                 630                 635                 640 
Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu
                645                 650                 655     
Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala
            660                 665                 670         
Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys
        675                 680                 685             
Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val
    690                 695                 700                 
Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val
705                 710                 715                 720 
Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg
                725                 730                 735     
Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp
            740                 745                 750         
Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg
        755                 760                 765             
Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp
    770                 775                 780                 
Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu
785                 790                 795                 800 
Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys
                805                 810                 815     
Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser
            820                 825                 830         
Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile
        835                 840                 845             
Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr
    850                 855                 860                 
Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala
865                 870                 875                 880 
Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met
                885                 890                 895     
Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr
            900                 905                 910         
Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro
        915                 920                 925             
Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro
    930                 935                 940                 
Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val
945                 950                 955                 960 
Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly
                965                 970                 975     
Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg
            980                 985                 990         
Pro Leu Lys Asn Asp Glu Leu
        995                 


<210> 5827
<211> 1007
<212> PRT
<213> Homo sapiens

<400> 5827
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr
 1               5                  10                  15      
Thr Cys Leu Ala Val Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe
            20                  25                  30          
Glu Glu Gln Pro Ile Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly
        35                  40                  45              
Lys Val Ser Leu Asn Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr
    50                  55                  60                  
Lys Trp Arg Met Asn Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr
65                  70                  75                  80  
Ser Met Val Gly Gly Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys
                85                  90                  95      
Asp Ala Gly Ile Tyr Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val
            100                 105                 110         
Arg Ser Thr Glu Ala Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro
        115                 120                 125             
Pro Glu Glu Arg Pro Glu Val Arg Val Lys Glu Gly Lys Gly Met Val
    130                 135                 140                 
Leu Leu Cys Asp Pro Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg
145                 150                 155                 160 
Trp Leu Leu Asn Glu Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg
                165                 170                 175     
Phe Val Ser Gln Thr Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala
            180                 185                 190         
Ser Asp Lys Gly Asn Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr
        195                 200                 205             
Lys Ser Val Phe Ser Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg
    210                 215                 220                 
Thr Thr Lys Pro Tyr Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val
225                 230                 235                 240 
Tyr Ala Leu Met Gly Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly
                245                 250                 255     
Asn Pro Val Pro Asp Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro
            260                 265                 270         
Ser Thr Ala Glu Ile Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn
        275                 280                 285             
Ile Gln Leu Glu Asp Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile
    290                 295                 300                 
Arg Gly Lys Asp Lys His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro
305                 310                 315                 320 
Glu Trp Val Glu His Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp
                325                 330                 335     
Leu Tyr Trp Pro Cys Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg
            340                 345                 350         
Trp Leu Lys Asn Gly Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr
        355                 360                 365             
Asp Val Thr Phe Glu Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn
    370                 375                 380                 
Thr Tyr Gly Ala Ile Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu
385                 390                 395                 400 
Ala Pro Thr Phe Glu Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala
                405                 410                 415     
Lys Gly Gly Arg Val Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys
            420                 425                 430         
Pro Lys Phe Ser Trp Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser
        435                 440                 445             
Arg Ile Leu Ile Trp Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr
    450                 455                 460                 
Arg Asn Asp Gly Gly Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly
465                 470                 475                 480 
Lys Ala Asn Ser Thr Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile
                485                 490                 495     
Ile Leu Ala Pro Ile Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr
            500                 505                 510         
Met Gln Cys Ala Ala Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val
        515                 520                 525             
Trp Ser Phe Asn Gly Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His
    530                 535                 540                 
Tyr Gln Arg Asn Phe Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg
545                 550                 555                 560 
Asn Ala Gln Leu Lys His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr
                565                 570                 575     
Ile Val Asp Asn Ser Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro
            580                 585                 590         
Pro Gly Pro Pro Gly Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser
        595                 600                 605             
Val Ala Leu Thr Trp Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser
    610                 615                 620                 
Lys Tyr Thr Ile Gln Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp
625                 630                 635                 640 
Ala Lys Thr Asp Pro Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg
                645                 650                 655     
Ala Val Asp Leu Ile Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala
            660                 665                 670         
Thr Asn Thr Leu Gly Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile
        675                 680                 685             
Lys Thr Asp Gly Ala Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly
    690                 695                 700                 
Gly Gly Gly Arg Asn Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser
705                 710                 715                 720 
Arg Glu Tyr His Tyr Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys
                725                 730                 735     
Pro Phe Asp Gly Glu Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp
            740                 745                 750         
Thr Gly Arg Tyr Val His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala
        755                 760                 765             
Phe Gln Val Lys Val Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr
    770                 775                 780                 
Ser Leu Val Ala Val Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala
785                 790                 795                 800 
Pro Thr Glu Val Gly Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val
                805                 810                 815     
His Trp Glu His Val Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg
            820                 825                 830         
Tyr Trp Ala Ala His Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val
        835                 840                 845             
Thr Ser Gln Glu Tyr Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr
    850                 855                 860                 
Gln Tyr Phe Ile Glu Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro
865                 870                 875                 880 
Pro Ser Asp Met Ile Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln
                885                 890                 895     
Pro Pro Arg Ile Ile Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile
            900                 905                 910         
Thr Trp Asp His Val Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly
        915                 920                 925             
Tyr Lys Val Leu Tyr Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr
    930                 935                 940                 
Ser Thr His Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu
945                 950                 955                 960 
Tyr Val Val Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val
                965                 970                 975     
Ser Gln Val Lys Ile Ser Gly Ala Pro Thr Leu Ser Pro Ser Leu Leu
            980                 985                 990         
Gly Leu Leu Leu Pro Ala Phe Gly Ile Leu Val Tyr Leu Glu Phe
        995                 1000                1005        


<210> 5828
<211> 1018
<212> PRT
<213> Homo sapiens

<400> 5828
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr
 1               5                  10                  15      
Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val
            20                  25                  30          
Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile
        35                  40                  45              
Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn
    50                  55                  60                  
Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn
65                  70                  75                  80  
Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr Ser Met Val Gly Gly
                85                  90                  95      
Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr
            100                 105                 110         
Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala
        115                 120                 125             
Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro
    130                 135                 140                 
Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro
145                 150                 155                 160 
Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu
                165                 170                 175     
Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr
            180                 185                 190         
Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn
        195                 200                 205             
Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser
    210                 215                 220                 
Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr
225                 230                 235                 240 
Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly
                245                 250                 255     
Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp
            260                 265                 270         
Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Thr Ala Glu Ile
        275                 280                 285             
Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp
    290                 295                 300                 
Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys
305                 310                 315                 320 
His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His
                325                 330                 335     
Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys
            340                 345                 350         
Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly
        355                 360                 365             
Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu
    370                 375                 380                 
Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Thr Tyr Gly Ala Ile
385                 390                 395                 400 
Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu
                405                 410                 415     
Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val
            420                 425                 430         
Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp
        435                 440                 445             
Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp
    450                 455                 460                 
Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly
465                 470                 475                 480 
Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr
                485                 490                 495     
Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile Ile Leu Ala Pro Ile
            500                 505                 510         
Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala
        515                 520                 525             
Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly
    530                 535                 540                 
Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe
545                 550                 555                 560 
Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys
                565                 570                 575     
His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser
            580                 585                 590         
Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro Pro Gly Pro Pro Gly
        595                 600                 605             
Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser Val Ala Leu Thr Trp
    610                 615                 620                 
Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser Lys Tyr Thr Ile Gln
625                 630                 635                 640 
Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp Ala Lys Thr Asp Pro
                645                 650                 655     
Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg Ala Val Asp Leu Ile
            660                 665                 670         
Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala Thr Asn Thr Leu Gly
        675                 680                 685             
Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile Lys Thr Asp Gly Ala
    690                 695                 700                 
Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly Gly Gly Gly Arg Asn
705                 710                 715                 720 
Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser Arg Glu Tyr His Tyr
                725                 730                 735     
Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys Pro Phe Asp Gly Glu
            740                 745                 750         
Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp Thr Gly Arg Tyr Val
        755                 760                 765             
His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala Phe Gln Val Lys Val
    770                 775                 780                 
Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr Ser Leu Val Ala Val
785                 790                 795                 800 
Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala Pro Thr Glu Val Gly
                805                 810                 815     
Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val His Trp Glu His Val
            820                 825                 830         
Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg Tyr Trp Ala Ala His
        835                 840                 845             
Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val Thr Ser Gln Glu Tyr
    850                 855                 860                 
Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr Gln Tyr Phe Ile Glu
865                 870                 875                 880 
Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro Pro Ser Asp Met Ile
                885                 890                 895     
Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln Pro Pro Arg Ile Ile
            900                 905                 910         
Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile Thr Trp Asp His Val
        915                 920                 925             
Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly Tyr Lys Val Leu Tyr
    930                 935                 940                 
Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr Ser Thr His Lys His
945                 950                 955                 960 
Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val Glu Val
                965                 970                 975     
Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val Lys Ile
            980                 985                 990         
Ser Gly Ala Pro Thr Leu Ser Pro Ser Leu Leu Gly Leu Leu Leu Pro
        995                 1000                1005            
Ala Phe Gly Ile Leu Val Tyr Leu Glu Phe
    1010                1015            


<210> 5829
<211> 416
<212> PRT
<213> Homo sapiens

<400> 5829
Met Ala Pro Arg Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Pro Val
 1               5                  10                  15      
Ala Ala Ala Arg Pro His Ala Leu Ser Ser Ala Ala Met Phe Met Val
            20                  25                  30          
Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala
        35                  40                  45              
Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr Phe
    50                  55                  60                  
Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys Gly
65                  70                  75                  80  
Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg Gly
                85                  90                  95      
His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val
            100                 105                 110         
Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe Pro
        115                 120                 125             
Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp Ile
    130                 135                 140                 
Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln Val
145                 150                 155                 160 
His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln Ala
                165                 170                 175     
Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu Gln
            180                 185                 190         
Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro Ser
        195                 200                 205             
Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val Ser
    210                 215                 220                 
Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn
225                 230                 235                 240 
Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu Asn
                245                 250                 255     
Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His Leu
            260                 265                 270         
Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe Gln
        275                 280                 285             
Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile Gln
    290                 295                 300                 
Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala Ala
305                 310                 315                 320 
Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr Lys
                325                 330                 335     
Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val Asn
            340                 345                 350         
Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln Phe
        355                 360                 365             
Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Thr Leu Ile Pro
    370                 375                 380                 
Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile
385                 390                 395                 400 
Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile
                405                 410                 415     


<210> 5830
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 5830
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
 1               5                  10                  15      
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
            20                  25                  30          
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
        35                  40                  45              
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
    50                  55                  60                  
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65                  70                  75                  80  
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
                85                  90                  95      
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
            100                 105                 110         
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
        115                 120                 125             
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
    130                 135                 140                 
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145                 150                 155                 160 
Ser Ser Val Tyr Ala Gly Asn Gly Ala Ile Leu Asn Cys Glu Val Asn
                165                 170                 175     
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
            180                 185                 190         
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
        195                 200                 205             
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
    210                 215                 220                 
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225                 230                 235                 240 
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
                245                 250                 255     
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
            260                 265                 270         
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
        275                 280                 285             
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
    290                 295                 300                 
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305                 310                 315                 320 
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
                325                 330                 335     
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
            340                 345                 350         
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
        355                 360                 365             
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
    370                 375                 380                 
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385                 390                 395                 400 
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
                405                 410                 415     
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
            420                 425                 430         
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
        435                 440                 445             
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
    450                 455                 460                 
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465                 470                 475                 480 
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
                485                 490                 495     
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
            500                 505                 510         
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
        515                 520                 525             
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
    530                 535                 540                 
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545                 550                 555                 560 
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
                565                 570                 575     
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
            580                 585                 590         
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
        595                 600                 605             
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
    610                 615                 620                 
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625                 630                 635                 640 
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
                645                 650                 655     
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
            660                 665                 670         
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
        675                 680                 685             
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
    690                 695                 700                 
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705                 710                 715                 720 
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
                725                 730                 735     
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
            740                 745                 750         
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
        755                 760                 765             
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
    770                 775                 780                 
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785                 790                 795                 800 
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
                805                 810                 815     
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
            820                 825                 830         
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
        835                 840                 845             
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
    850                 855                 860                 
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865                 870                 875                 880 
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
                885                 890                 895     
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
            900                 905                 910         
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
        915                 920                 925             
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
    930                 935                 940                 
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945                 950                 955                 960 
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
                965                 970                 975     
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
            980                 985                 990         
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
        995                 1000                1005            
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu
    1010                1015                1020                
Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met
1025                1030                1035                1040
Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser
                1045                1050                1055    
Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly
            1060                1065                1070        
Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly
        1075                1080                1085            
Ser Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met
    1090                1095                1100                
Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val
1105                1110                1115                1120
Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys
                1125                1130                1135    
Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys
            1140                1145                1150        
Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu
        1155                1160                1165            
Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile
    1170                1175                1180                
Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val
1185                1190                1195                1200
Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg
                1205                1210                1215    
Gly His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly
            1220                1225                1230        
Met Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Glu
        1235                1240                1245            
Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met Pro Ala Ser Ser Ser
    1250                1255                1260                
Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu Gly Ala Thr Ser Ser
1265                1270                1275                1280
Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser Gly Gln Ser Leu Pro
                1285                1290                1295    
Thr Ala His Val Arg Pro Ser His Pro Leu Lys Ser Phe Ala Val Pro
            1300                1305                1310        
Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp Pro Ala Leu Pro Ser
        1315                1320                1325            
Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His His Ile His Ser Val
    1330                1335                1340                
Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser Arg Pro Pro Met Pro
1345                1350                1355                1360
Val Val Val Pro Ser Ala Pro Glu Val Gln Glu Thr Thr Arg Met Leu
                1365                1370                1375    
Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu Leu Thr Lys Glu Met
            1380                1385                1390        
Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn Ala Ile Thr Thr Ala
        1395                1400                1405            


<210> 5831
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 5831
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
 1               5                  10                  15      
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
            20                  25                  30          
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
        35                  40                  45              
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
    50                  55                  60                  
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65                  70                  75                  80  
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
                85                  90                  95      
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
            100                 105                 110         
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
        115                 120                 125             
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
    130                 135                 140                 
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145                 150                 155                 160 
Ser Ser Val Tyr Ala Gly Asn Gly Ala Ile Leu Asn Cys Glu Val Asn
                165                 170                 175     
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
            180                 185                 190         
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
        195                 200                 205             
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
    210                 215                 220                 
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225                 230                 235                 240 
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
                245                 250                 255     
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
            260                 265                 270         
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
        275                 280                 285             
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
    290                 295                 300                 
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305                 310                 315                 320 
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
                325                 330                 335     
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
            340                 345                 350         
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
        355                 360                 365             
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
    370                 375                 380                 
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385                 390                 395                 400 
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
                405                 410                 415     
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
            420                 425                 430         
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
        435                 440                 445             
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
    450                 455                 460                 
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465                 470                 475                 480 
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
                485                 490                 495     
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
            500                 505                 510         
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
        515                 520                 525             
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
    530                 535                 540                 
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545                 550                 555                 560 
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
                565                 570                 575     
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
            580                 585                 590         
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
        595                 600                 605             
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
    610                 615                 620                 
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625                 630                 635                 640 
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
                645                 650                 655     
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
            660                 665                 670         
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
        675                 680                 685             
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
    690                 695                 700                 
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705                 710                 715                 720 
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
                725                 730                 735     
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
            740                 745                 750         
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
        755                 760                 765             
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
    770                 775                 780                 
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785                 790                 795                 800 
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
                805                 810                 815     
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
            820                 825                 830         
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
        835                 840                 845             
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
    850                 855                 860                 
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865                 870                 875                 880 
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
                885                 890                 895     
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
            900                 905                 910         
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
        915                 920                 925             
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
    930                 935                 940                 
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945                 950                 955                 960 
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
                965                 970                 975     
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
            980                 985                 990         
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
        995                 1000                1005            
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu
    1010                1015                1020                
Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met
1025                1030                1035                1040
Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser
                1045                1050                1055    
Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly
            1060                1065                1070        
Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly
        1075                1080                1085            
Ser Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met
    1090                1095                1100                
Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val
1105                1110                1115                1120
Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys
                1125                1130                1135    
Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys
            1140                1145                1150        
Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu
        1155                1160                1165            
Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile
    1170                1175                1180                
Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val
1185                1190                1195                1200
Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg
                1205                1210                1215    
Gly His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly
            1220                1225                1230        
Met Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro
        1235                1240                1245            
Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His His
    1250                1255                1260                
Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu Tyr His
1265                1270                1275                1280
Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu Ser Asp Arg
                1285                1290                1295    
Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met
            1300                1305                1310        
Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu
        1315                1320                1325            
Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser
    1330                1335                1340                
Gly Gln Ser Leu Pro Thr Ala His Val Arg Pro Ser His Pro Leu Lys
1345                1350                1355                1360
Ser Phe Ala Val Pro Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp
                1365                1370                1375    
Pro Ala Leu Pro Ser Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His
            1380                1385                1390        
His Ile His Ser Val Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser
        1395                1400                1405            
Arg Pro Pro Met Pro Val Val Val Pro Ser Ala Pro Glu Val Gln Glu
    1410                1415                1420                
Thr Thr Arg Met Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu
1425                1430                1435                1440
Leu Thr Lys Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn
                1445                1450                1455    
Ala Ile Thr Thr Ala
            1460    


<210> 5832
<211> 416
<212> PRT
<213> Homo sapiens

<400> 5832
Met Ser Glu Ala Asp Gly Leu Arg Gln Arg Arg Pro Leu Arg Pro Gln
 1               5                  10                  15      
Val Val Thr Asp Asp Asp Gly Gln Ala Pro Glu Ala Lys Asp Gly Ser
            20                  25                  30          
Ser Phe Ser Gly Arg Val Phe Arg Val Thr Phe Leu Met Leu Ala Val
        35                  40                  45              
Ser Leu Thr Val Pro Leu Leu Gly Ala Met Met Leu Leu Glu Ser Pro
    50                  55                  60                  
Ile Asp Pro Gln Pro Leu Ser Phe Lys Glu Pro Pro Leu Leu Leu Gly
65                  70                  75                  80  
Val Leu His Pro Asn Thr Lys Leu Arg Gln Ala Glu Arg Leu Phe Glu
                85                  90                  95      
Asn Gln Leu Val Gly Pro Glu Ser Ile Ala His Ile Gly Asp Val Met
            100                 105                 110         
Phe Thr Gly Thr Ala Asp Gly Arg Val Val Lys Leu Glu Asn Gly Glu
        115                 120                 125             
Ile Glu Thr Ile Ala Arg Phe Gly Ser Gly Pro Cys Lys Thr Arg Asp
    130                 135                 140                 
Asp Glu Pro Val Cys Gly Arg Pro Leu Gly Ile Arg Ala Gly Pro Asn
145                 150                 155                 160 
Gly Thr Leu Phe Val Ala Asp Ala Tyr Lys Gly Leu Phe Glu Val Asn
                165                 170                 175     
Pro Trp Lys Arg Glu Val Lys Leu Leu Leu Ser Ser Glu Thr Pro Ile
            180                 185                 190         
Glu Gly Lys Asn Met Ser Phe Val Asn Asp Leu Thr Val Thr Gln Asp
        195                 200                 205             
Gly Arg Lys Ile Tyr Phe Thr Asp Ser Ser Ser Lys Trp Gln Arg Arg
    210                 215                 220                 
Asp Tyr Leu Leu Leu Val Met Glu Gly Thr Asp Asp Gly Arg Leu Leu
225                 230                 235                 240 
Glu Tyr Asp Thr Val Thr Arg Glu Val Lys Val Leu Leu Asp Gln Leu
                245                 250                 255     
Arg Phe Pro Asn Gly Val Gln Leu Ser Pro Ala Glu Asp Phe Val Leu
            260                 265                 270         
Val Ala Glu Thr Thr Met Ala Arg Ile Arg Arg Val Tyr Val Ser Gly
        275                 280                 285             
Leu Met Lys Gly Gly Ala Asp Leu Phe Val Glu Asn Met Pro Gly Phe
    290                 295                 300                 
Pro Asp Asn Ile Arg Pro Ser Ser Ser Gly Gly Tyr Trp Val Gly Met
305                 310                 315                 320 
Ser Thr Ile Arg Pro Asn Pro Gly Phe Ser Met Leu Asp Phe Leu Ser
                325                 330                 335     
Glu Arg Pro Trp Ile Lys Arg Met Ile Phe Lys Leu Phe Ser Gln Glu
            340                 345                 350         
Thr Val Met Lys Phe Val Pro Arg Tyr Ser Leu Val Leu Glu Leu Ser
        355                 360                 365             
Asp Ser Gly Ala Phe Arg Arg Ser Leu His Asp Pro Asp Gly Leu Val
    370                 375                 380                 
Ala Thr Tyr Ile Ser Glu Val His Glu His Asp Gly His Leu Tyr Leu
385                 390                 395                 400 
Gly Ser Phe Arg Ser Pro Phe Leu Cys Arg Leu Ser Leu Gln Ala Val
                405                 410                 415     


<210> 5833
<211> 1156
<212> PRT
<213> Homo sapiens

<400> 5833
Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp Phe Arg Arg His Phe
 1               5                  10                  15      
Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val Leu Leu Leu Ser Ala
            20                  25                  30          
Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg Leu
        35                  40                  45              
Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val Glu Val Lys Val Gln
    50                  55                  60                  
Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu Ala Val
65                  70                  75                  80  
Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr Ala Ile Lys Ala Pro
                85                  90                  95      
Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg Ile Trp Met Asp His
            100                 105                 110         
Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp Asp Cys Lys His Asp
        115                 120                 125             
Gly Trp Gly Lys His Ser Asn Cys Thr His Gln Gln Asp Ala Gly Val
    130                 135                 140                 
Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg Leu Thr Arg Gly Gly
145                 150                 155                 160 
Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe Gln Gly Arg Trp Gly
                165                 170                 175     
Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His Ala Ser Val Ile Cys
            180                 185                 190         
Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe Ser Gly Ser Ser Asn
        195                 200                 205             
Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp Asp Leu Ile Cys Asn
    210                 215                 220                 
Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His Gln Gly Trp Gly Lys
225                 230                 235                 240 
His Asn Cys Asp His Ala Glu Asp Ala Gly Val Ile Cys Ser Lys Gly
                245                 250                 255     
Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val Thr Glu Cys Ser Gly
            260                 265                 270         
Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly Thr Ile Cys Asp Asp
        275                 280                 285             
Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys Lys Gln Leu Gly Cys
    290                 295                 300                 
Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn Ala Ser Lys Gly Phe
305                 310                 315                 320 
Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln Gly His Glu Pro Ala
                325                 330                 335     
Val Trp Gln Cys Lys His His Glu Trp Gly Lys His Tyr Cys Asn His
            340                 345                 350         
Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asp Leu Glu Leu
        355                 360                 365             
Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly Thr Val Glu Val Glu
    370                 375                 380                 
Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg Gly Trp Gly Leu Lys
385                 390                 395                 400 
Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys Gly Ser Ala Leu Lys
                405                 410                 415     
Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala Thr Asn Thr Trp Leu
            420                 425                 430         
Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser Leu Trp Asp Cys Lys
        435                 440                 445             
Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His Tyr Glu Glu Ala Lys
    450                 455                 460                 
Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu Val Gly Gly Asp Ile
465                 470                 475                 480 
Pro Cys Ser Gly Arg Val Glu Val Lys His Gly Asp Thr Trp Gly Ser
                485                 490                 495     
Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala Ser Val Leu Cys Arg
            500                 505                 510         
Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu Gly Gly Ala His Phe
        515                 520                 525             
Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu Phe Gln Cys Glu Gly
    530                 535                 540                 
His Glu Ser His Leu Ser Leu Cys Pro Val Ala Pro Arg Pro Glu Gly
545                 550                 555                 560 
Thr Cys Ser His Ser Arg Asp Val Gly Val Val Cys Ser Arg Tyr Thr
                565                 570                 575     
Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys Glu Gly Arg Val Glu
            580                 585                 590         
Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys Asn Ser His Trp Asp
        595                 600                 605             
Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu Lys Cys Gly Val Ala
    610                 615                 620                 
Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys Gly Asn Gly Gln Ile
625                 630                 635                 640 
Trp Arg His Met Phe His Cys Thr Gly Thr Glu Gln His Met Gly Asp
                645                 650                 655     
Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys Pro Ser Glu Gln Val
            660                 665                 670         
Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln Thr Leu Ser Ser Cys
        675                 680                 685             
Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr Ile Pro Glu Glu Ser
    690                 695                 700                 
Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg Leu Val Asn Gly Gly
705                 710                 715                 720 
Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His Glu Gly Ser Trp Gly
                725                 730                 735     
Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp Ala His Val Val Cys
            740                 745                 750         
Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala Thr Gly Ser Ala His
        755                 760                 765             
Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp Glu Met Lys Cys Asn
    770                 775                 780                 
Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser His Gly Trp Gly Gln
785                 790                 795                 800 
Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val Ile Cys Ser Glu Phe
                805                 810                 815     
Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg Glu Ala Cys Ala Gly
            820                 825                 830         
Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly Thr Val Gly Lys Ser
        835                 840                 845             
Ser Met Ser Glu Thr Thr Val Gly Val Val Cys Arg Gln Leu Gly Cys
    850                 855                 860                 
Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu Asp Lys Ala Met Ser
865                 870                 875                 880 
Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro Lys Gly Pro Asp Thr
                885                 890                 895     
Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys Arg Leu Ala Ser Pro
            900                 905                 910         
Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys Ile Arg Leu Gln Glu
        915                 920                 925             
Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile Trp His Gly Gly Ser
    930                 935                 940                 
Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu Asp Asp Ala Gln Val
945                 950                 955                 960 
Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu Lys Ala Phe Lys Glu
                965                 970                 975     
Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu Val Lys
            980                 985                 990         
Cys Lys Gly Asn Glu Ser Ser Leu Trp Asp Cys Pro Ala Arg Arg Trp
        995                 1000                1005            
Gly His Ser Glu Cys Gly His Lys Glu Asp Ala Ala Val Asn Cys Thr
    1010                1015                1020                
Asp Ile Ser Val Gln Lys Thr Pro Gln Lys Ala Thr Thr Gly Arg Ser
1025                1030                1035                1040
Ser Arg Gln Ser Ser Phe Ile Ala Val Gly Ile Leu Gly Val Val Leu
                1045                1050                1055    
Leu Ala Ile Phe Val Ala Leu Phe Phe Leu Thr Lys Lys Arg Arg Gln
            1060                1065                1070        
Arg Gln Arg Leu Ala Val Ser Ser Arg Gly Glu Asn Leu Val His Gln
        1075                1080                1085            
Ile Gln Tyr Arg Glu Met Asn Ser Cys Leu Asn Ala Asp Asp Leu Asp
    1090                1095                1100                
Leu Met Asn Ser Ser Gly Leu Trp Val Leu Gly Gly Ser Ile Ala Gln
1105                1110                1115                1120
Gly Phe Arg Ser Val Ala Ala Val Glu Ala Gln Thr Phe Tyr Phe Asp
                1125                1130                1135    
Lys Gln Leu Lys Lys Ser Lys Asn Val Ile Gly Ser Leu Asp Ala Tyr
            1140                1145                1150        
Asn Gly Gln Glu
        1155    


<210> 5834
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 5834
Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr
 1               5                  10                  15      
Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp
            20                  25                  30          
Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His
        35                  40                  45              
Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp
    50                  55                  60                  
Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn
65                  70                  75                  80  
Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro
                85                  90                  95      
Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly
            100                 105                 110         
Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro
        115                 120                 125             
Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro
    130                 135                 140                 
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala
145                 150                 155                 160 
Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser
                165                 170                 175     
Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro
            180                 185                 190         
Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro
        195                 200                 205             
Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly
    210                 215                 220                 
Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg
225                 230                 235                 240 
Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro
                245                 250                 255     
Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly
            260                 265                 270         
Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu
        275                 280                 285             
Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg
    290                 295                 300                 
Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly
305                 310                 315                 320 
Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro
                325                 330                 335     
Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys
            340                 345                 350         
Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly
        355                 360                 365             
Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro
    370                 375                 380                 
Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn
385                 390                 395                 400 
Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly
                405                 410                 415     
Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn
            420                 425                 430         
Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys
        435                 440                 445             
Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly
    450                 455                 460                 
Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu
465                 470                 475                 480 
Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro
                485                 490                 495     
Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly
            500                 505                 510         
Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg
        515                 520                 525             
Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro
    530                 535                 540                 
Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly
545                 550                 555                 560 
Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln
                565                 570                 575     
Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro
            580                 585                 590         
Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly
        595                 600                 605             
Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro
    610                 615                 620                 
Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro
625                 630                 635                 640 
Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly
                645                 650                 655     
Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro
            660                 665                 670         
Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln
        675                 680                 685             
Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly
    690                 695                 700                 
Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser
705                 710                 715                 720 
Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala
                725                 730                 735     
Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly
            740                 745                 750         
Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro
        755                 760                 765             
Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser
    770                 775                 780                 
Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly
785                 790                 795                 800 
Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro
                805                 810                 815     
Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala
            820                 825                 830         
Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly
        835                 840                 845             
Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala
    850                 855                 860                 
Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala
865                 870                 875                 880 
Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly
                885                 890                 895     
Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu
            900                 905                 910         
Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro
        915                 920                 925             
Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly
    930                 935                 940                 
Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val
945                 950                 955                 960 
Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro
                965                 970                 975     
Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly
            980                 985                 990         
Glu Arg Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Ala Gly Pro
        995                 1000                1005            
Pro Gly Glu Ser Gly Arg Glu Gly Ala Pro Gly Ala Glu Gly Ser Pro
    1010                1015                1020                
Gly Arg Asp Gly Ser Pro Gly Ala Lys Gly Asp Arg Gly Glu Thr Gly
1025                1030                1035                1040
Pro Ala Gly Pro Pro Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly Pro
                1045                1050                1055    
Val Gly Pro Ala Gly Lys Ser Gly Asp Arg Gly Glu Thr Gly Pro Ala
            1060                1065                1070        
Gly Pro Ala Gly Pro Val Gly Pro Ala Gly Ala Arg Gly Pro Ala Gly
        1075                1080                1085            
Pro Gln Gly Pro Arg Gly Asp Lys Gly Glu Thr Gly Glu Gln Gly Asp
    1090                1095                1100                
Arg Gly Ile Lys Gly His Arg Gly Phe Ser Gly Leu Gln Gly Pro Pro
1105                1110                1115                1120
Gly Pro Pro Gly Ser Pro Gly Glu Gln Gly Pro Ser Gly Ala Ser Gly
                1125                1130                1135    
Pro Ala Gly Pro Arg Gly Pro Pro Gly Ser Ala Gly Ala Pro Gly Lys
            1140                1145                1150        
Asp Gly Leu Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg
        1155                1160                1165            
Gly Arg Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly
    1170                1175                1180                
Pro Pro Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe
1185                1190                1195                1200
Leu Pro Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr
                1205                1210                1215    
Arg Ala Asp Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp
            1220                1225                1230        
Thr Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro
        1235                1240                1245            
Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met
    1250                1255                1260                
Cys His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln
1265                1270                1275                1280
Gly Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly
                1285                1290                1295    
Glu Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp
            1300                1305                1310        
Tyr Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu
        1315                1320                1325            
Ser Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp
    1330                1335                1340                
Pro Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr
1345                1350                1355                1360
Glu Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr
                1365                1370                1375    
Met Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly
            1380                1385                1390        
Ser Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr
        1395                1400                1405            
Ser Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys
    1410                1415                1420                
Thr Val Ile Glu Tyr Lys Thr Thr Lys Thr Ser Arg Leu Pro Ile Ile
1425                1430                1435                1440
Asp Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe
                1445                1450                1455    
Asp Val Gly Pro Val Cys Phe Leu
            1460                


<210> 5835
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 5835
Met Leu Val Gly Gln Gly Ala Gly Pro Leu Gly Pro Ala Val Val Thr
 1               5                  10                  15      
Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser
            20                  25                  30          
Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu
        35                  40                  45              
Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr
    50                  55                  60                  
Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile
65                  70                  75                  80  
Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu
                85                  90                  95      
Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val
            100                 105                 110         
Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly
        115                 120                 125             
Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro
    130                 135                 140                 
Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile
145                 150                 155                 160 
Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val
                165                 170                 175     
Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu
            180                 185                 190         
Lys Glu Ala Ser Thr Thr Val Arg Val Thr Asn Ser Asn Ala Asn Ala
        195                 200                 205             
Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg
    210                 215                 220                 
Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser
225                 230                 235                 240 
Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro
                245                 250                 255     
Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val
            260                 265                 270         
Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly
        275                 280                 285             
Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val
    290                 295                 300                 
Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile
305                 310                 315                 320 
Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu
                325                 330                 335     
Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn
            340                 345                 350         
Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu
        355                 360                 365             
Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu
    370                 375                 380                 
Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu
385                 390                 395                 400 
Ala Asp Ile Ile Ala Thr Gly Phe Ser Val Cys Gly Gln Ile Ser Ile
                405                 410                 415     
Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val
            420                 425                 430         
Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp
        435                 440                 445             
Ala His Gly Ser Phe Cys Phe Lys Ala Lys Pro Gly Thr Tyr Lys Val
    450                 455                 460                 
Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys
465                 470                 475                 480 
Pro Gln Thr Phe Pro Leu Thr Val Thr Asn Arg Pro Val Met Asp Val
                485                 490                 495     
Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu
            500                 505                 510         
Asp Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln
        515                 520                 525             
Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr
    530                 535                 540                 
Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met
545                 550                 555                 560 
His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu
                565                 570                 575     
Glu Asp Asp Val Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu
            580                 585                 590         
Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly
        595                 600                 605             
Asn Gly Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly Val Asn
    610                 615                 620                 
Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser
625                 630                 635                 640 
Cys His Arg Phe Glu Gln Ala Phe Tyr Thr Tyr Asp Thr Ser Ser Pro
                645                 650                 655     
Ser Ile Leu Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile
            660                 665                 670         
Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile
        675                 680                 685             
Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu
    690                 695                 700                 
Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu
705                 710                 715                 720 
Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro
                725                 730                 735     
Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp
            740                 745                 750         
Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser
        755                 760                 765             
Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser
    770                 775                 780                 
Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly
785                 790                 795                 800 
Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile
                805                 810                 815     
Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr
            820                 825                 830         
Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu
        835                 840                 845             
Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu
    850                 855                 860                 
Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe
865                 870                 875                 880 
Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser
                885                 890                 895     
Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly
            900                 905                 910         
Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro
        915                 920                 925             
Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val
    930                 935                 940                 
Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala
945                 950                 955                 960 
Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln
                965                 970                 975     
Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly
            980                 985                 990         
Glu Asp Thr Val Thr Asp Glu Glu Gly Lys Phe Arg Leu Arg Gly Leu
        995                 1000                1005            
Leu Pro Gly Cys Val Tyr His Val Gln Leu Lys Ala Glu Gly Asn Asp
    1010                1015                1020                
His Ile Glu Arg Ala Leu Pro His His Arg Val Ile Glu Val Gly Asn
1025                1030                1035                1040
Asn Asp Ile Asp Asp Val Asn Ile Ile Val Phe Arg Gln Ile Asn Gln
                1045                1050                1055    
Phe Asp Leu Ser Gly Asn Val Ile Thr Ser Ser Glu Tyr Leu Pro Thr
            1060                1065                1070        
Leu Trp Val Lys Leu Tyr Lys Ser Glu Asn Leu Asp Asn Pro Ile Gln
        1075                1080                1085            
Thr Val Ser Leu Gly Gln Ser Leu Phe Phe His Phe Pro Pro Leu Leu
    1090                1095                1100                
Arg Asp Gly Glu Asn Tyr Val Val Leu Leu Asp Ser Thr Leu Pro Arg
1105                1110                1115                1120
Ser Gln Tyr Asp Tyr Ile Leu Pro Gln Val Ser Phe Thr Ala Val Gly
                1125                1130                1135    
Tyr His Lys His Phe Thr Leu Ile Phe Asn Pro Thr Arg Lys Leu Pro
            1140                1145                1150        
Glu Gln Asp Ile Ala Gln Gly Ser Tyr Ile Ala Leu Pro Leu Thr Leu
        1155                1160                1165            
Leu Val Leu Leu Ala Gly Tyr Asn His Asp Lys Leu Ile Pro Leu Leu
    1170                1175                1180                
Leu Gln Leu Thr Ser Arg Leu Gln Gly Val Arg Ala Leu Gly Gln Ala
1185                1190                1195                1200
Ala Ser Asp Asn Ser Gly Pro Glu Asp Ala Lys Arg Gln Ala Lys Lys
                1205                1210                1215    
Gln Lys Thr Arg Arg Thr
            1220        


<210> 5836
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 5836
Met Leu Val Gly Gln Gly Ala Gly Leu Leu Gly Pro Ala Val Val Thr
 1               5                  10                  15      
Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser
            20                  25                  30          
Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu
        35                  40                  45              
Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr
    50                  55                  60                  
Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile
65                  70                  75                  80  
Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu
                85                  90                  95      
Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val
            100                 105                 110         
Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly
        115                 120                 125             
Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro
    130                 135                 140                 
Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile
145                 150                 155                 160 
Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val
                165                 170                 175     
Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu
            180                 185                 190         
Lys Glu Ala Ser Thr Thr Val Arg Val Thr Asn Ser Asn Ala Asn Ala
        195                 200                 205             
Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg
    210                 215                 220                 
Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser
225                 230                 235                 240 
Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro
                245                 250                 255     
Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val
            260                 265                 270         
Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly
        275                 280                 285             
Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val
    290                 295                 300                 
Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile
305                 310                 315                 320 
Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu
                325                 330                 335     
Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn
            340                 345                 350         
Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu
        355                 360                 365             
Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu
    370                 375                 380                 
Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu
385                 390                 395                 400 
Ala Asp Ile Val Ala Thr Gly Phe Ser Val Cys Gly Arg Ile Ser Ile
                405                 410                 415     
Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val
            420                 425                 430         
Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp
        435                 440                 445             
Ala His Gly Ser Phe Cys Phe Lys Ala Lys Pro Gly Thr Tyr Lys Val
    450                 455                 460                 
Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys
465                 470                 475                 480 
Pro Gln Thr Phe Pro Leu Thr Val Thr Asp Arg Pro Val Met Asp Val
                485                 490                 495     
Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu
            500                 505                 510         
Asp Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln
        515                 520                 525             
Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr
    530                 535                 540                 
Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met
545                 550                 555                 560 
His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu
                565                 570                 575     
Glu Asp Asp Val Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu
            580                 585                 590         
Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly
        595                 600                 605             
Asn Gly Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly Val Asn
    610                 615                 620                 
Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser
625                 630                 635                 640 
Cys His Arg Phe Glu Gln Ala Phe Tyr Thr Tyr Asp Thr Ser Ser Pro
                645                 650                 655     
Ser Ile Leu Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile
            660                 665                 670         
Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile
        675                 680                 685             
Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu
    690                 695                 700                 
Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu
705                 710                 715                 720 
Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro
                725                 730                 735     
Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp
            740                 745                 750         
Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser
        755                 760                 765             
Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser
    770                 775                 780                 
Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly
785                 790                 795                 800 
Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile
                805                 810                 815     
Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr
            820                 825                 830         
Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu
        835                 840                 845             
Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu
    850                 855                 860                 
Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe
865                 870                 875                 880 
Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser
                885                 890                 895     
Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly
            900                 905                 910         
Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro
        915                 920                 925             
Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val
    930                 935                 940                 
Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala
945                 950                 955                 960 
Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln
                965                 970                 975     
Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly
            980                 985                 990         
Glu Asp Thr Val Thr Asp Glu Glu Gly Lys Phe Arg Leu Arg Gly Leu
        995                 1000                1005            
Leu Pro Gly Cys Val Tyr His Val Gln Leu Lys Ala Glu Gly Asn Asp
    1010                1015                1020                
His Ile Glu Arg Ala Leu Pro His His Arg Val Ile Glu Val Gly Asn
1025                1030                1035                1040
Asn Asp Ile Asp Asp Val Asn Ile Ile Val Phe Arg Gln Ile Asn Gln
                1045                1050                1055    
Phe Asp Leu Ser Gly Asn Val Ile Thr Ser Ser Glu Tyr Leu Pro Thr
            1060                1065                1070        
Leu Trp Val Lys Leu Tyr Lys Ser Glu Asn Leu Asp Asn Pro Ile Gln
        1075                1080                1085            
Thr Val Ser Leu Gly Gln Ser Leu Phe Phe His Phe Pro Pro Leu Leu
    1090                1095                1100                
Arg Asp Gly Glu Asn Tyr Val Val Leu Leu Asp Ser Thr Leu Pro Arg
1105                1110                1115                1120
Ser Gln Tyr Asp Tyr Ile Leu Pro Gln Val Ser Phe Thr Ala Val Gly
                1125                1130                1135    
Tyr His Lys His Ile Thr Leu Ile Phe Asn Pro Thr Arg Lys Leu Pro
            1140                1145                1150        
Glu Gln Asp Ile Ala Gln Gly Ser Tyr Ile Ala Leu Pro Leu Thr Leu
        1155                1160                1165            
Leu Val Leu Leu Ala Gly Tyr Asn His Asp Lys Leu Ile Pro Leu Leu
    1170                1175                1180                
Leu Gln Leu Thr Ser Arg Leu Gln Gly Val Gly Ala Leu Gly Gln Ala
1185                1190                1195                1200
Ala Ser Asp Asn Ser Gly Pro Glu Asp Ala Lys Arg Gln Ala Lys Lys
                1205                1210                1215    
Gln Lys Thr Arg Arg Thr
            1220        


<210> 5837
<211> 2537
<212> PRT
<213> Homo sapiens

<400> 5837
Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys
 1               5                  10                  15      
Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys
            20                  25                  30          
Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu
        35                  40                  45              
Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg
    50                  55                  60                  
Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val
65                  70                  75                  80  
Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser
                85                  90                  95      
Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly
            100                 105                 110         
Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp
        115                 120                 125             
Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg
    130                 135                 140                 
Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn
145                 150                 155                 160 
Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp
                165                 170                 175     
Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln
            180                 185                 190         
Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp
        195                 200                 205             
Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp
    210                 215                 220                 
Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala
225                 230                 235                 240 
Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys
                245                 250                 255     
Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys
            260                 265                 270         
Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp
        275                 280                 285             
Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln
    290                 295                 300                 
Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu
305                 310                 315                 320 
Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln
                325                 330                 335     
His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly
            340                 345                 350         
Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly
        355                 360                 365             
Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala
    370                 375                 380                 
Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn
385                 390                 395                 400 
Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys
                405                 410                 415     
Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe
            420                 425                 430         
Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu
        435                 440                 445             
Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro
    450                 455                 460                 
Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys
465                 470                 475                 480 
Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly
                485                 490                 495     
Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala
            500                 505                 510         
Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr
        515                 520                 525             
Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly
    530                 535                 540                 
Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His
545                 550                 555                 560 
Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly
                565                 570                 575     
Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala
            580                 585                 590         
Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr
        595                 600                 605             
Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp
    610                 615                 620                 
Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr
625                 630                 635                 640 
Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu
                645                 650                 655     
Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro
            660                 665                 670         
Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu
        675                 680                 685             
Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr
    690                 695                 700                 
Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val
705                 710                 715                 720 
Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile
                725                 730                 735     
Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val
            740                 745                 750         
Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp
        755                 760                 765             
Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp
    770                 775                 780                 
Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile
785                 790                 795                 800 
His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala
                805                 810                 815     
Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala
            820                 825                 830         
Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val
        835                 840                 845             
Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys
    850                 855                 860                 
Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu
865                 870                 875                 880 
Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu
                885                 890                 895     
Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro
            900                 905                 910         
Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro
        915                 920                 925             
Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu
    930                 935                 940                 
Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys
945                 950                 955                 960 
Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys
                965                 970                 975     
Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu
            980                 985                 990         
Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro
        995                 1000                1005            
Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro
    1010                1015                1020                
Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro
1025                1030                1035                1040
Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly
                1045                1050                1055    
Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly
            1060                1065                1070        
Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser
        1075                1080                1085            
Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro
    1090                1095                1100                
Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly
1105                1110                1115                1120
Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val
                1125                1130                1135    
Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly
            1140                1145                1150        
Leu Leu Ser Val Asn Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu
        1155                1160                1165            
Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn
    1170                1175                1180                
Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly
1185                1190                1195                1200
Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe
                1205                1210                1215    
Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys
            1220                1225                1230        
Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr
        1235                1240                1245            
Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp
    1250                1255                1260                
His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys
1265                1270                1275                1280
Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro
                1285                1290                1295    
Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro
            1300                1305                1310        
Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro
        1315                1320                1325            
Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn
    1330                1335                1340                
Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly
1345                1350                1355                1360
Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg
                1365                1370                1375    
Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro
            1380                1385                1390        
Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly
        1395                1400                1405            
Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val
    1410                1415                1420                
Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu
1425                1430                1435                1440
Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu
                1445                1450                1455    
Val Arg Val Leu Gly Pro Arg Gly Leu Val Glu Pro Val Asn Met Val
            1460                1465                1470        
Asp Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu
        1475                1480                1485            
Gly Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg
    1490                1495                1500                
Ser Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val
1505                1510                1515                1520
Thr Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu
                1525                1530                1535    
Pro Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu
            1540                1545                1550        
Ala Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val
        1555                1560                1565            
His Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys
    1570                1575                1580                
Thr Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro
1585                1590                1595                1600
Leu Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys
                1605                1610                1615    
Cys Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu
            1620                1625                1630        
Glu Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val
        1635                1640                1645            
Thr Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val
    1650                1655                1660                
Ile Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys
1665                1670                1675                1680
Pro Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro
                1685                1690                1695    
Asn Ser Pro Phe Thr Val Met Val Thr Glu Glu Ala Tyr Val Pro Val
            1700                1705                1710        
Ser Asp Met Asn Gly Leu Gly Phe Lys Pro Phe Asp Leu Val Ile Pro
        1715                1720                1725            
Phe Ala Val Arg Lys Gly Glu Ile Thr Gly Glu Val His Met Pro Ser
    1730                1735                1740                
Gly Lys Thr Ala Thr Pro Glu Ile Val Asp Asn Lys Asp Gly Thr Val
1745                1750                1755                1760
Thr Val Arg Tyr Ala Pro Thr Glu Val Gly Leu His Glu Met His Ile
                1765                1770                1775    
Lys Tyr Met Gly Ser His Ile Pro Glu Ser Pro Leu Gln Phe Tyr Val
            1780                1785                1790        
Asn Tyr Pro Asn Ser Gly Ser Val Ser Ala Tyr Gly Pro Gly Leu Val
        1795                1800                1805            
Tyr Gly Val Ala Asn Lys Thr Ala Thr Phe Thr Ile Val Thr Glu Asp
    1810                1815                1820                
Ala Gly Glu Gly Gly Leu Asp Leu Ala Ile Glu Gly Pro Ser Lys Ala
1825                1830                1835                1840
Glu Ile Ser Cys Ile Asp Asn Lys Asp Gly Thr Cys Thr Val Thr Tyr
                1845                1850                1855    
Leu Pro Thr Leu Pro Gly Asp Tyr Ser Ile Leu Val Lys Tyr Asn Asp
            1860                1865                1870        
Lys His Ile Pro Gly Ser Pro Phe Thr Ala Lys Ile Thr Asp Asp Ser
        1875                1880                1885            
Arg Arg Cys Ser Gln Val Lys Leu Gly Ser Ala Ala Asp Phe Leu Leu
    1890                1895                1900                
Asp Ile Ser Glu Thr Asp Leu Ser Ser Leu Thr Ala Ser Ile Lys Ala
1905                1910                1915                1920
Pro Ser Gly Arg Asp Glu Pro Cys Leu Leu Lys Arg Leu Pro Asn Asn
                1925                1930                1935    
His Ile Gly Ile Ser Phe Ile Pro Arg Glu Val Gly Glu His Leu Val
            1940                1945                1950        
Ser Ile Lys Lys Asn Gly Asn His Val Ala Asn Ser Pro Val Ser Ile
        1955                1960                1965            
Met Val Val Gln Ser Glu Ile Gly Asp Ala Arg Arg Ala Lys Val Tyr
    1970                1975                1980                
Gly Arg Gly Leu Ser Glu Gly Arg Thr Phe Glu Met Ser Asp Phe Ile
1985                1990                1995                2000
Val Asp Thr Arg Asp Ala Gly Tyr Gly Gly Ile Ser Leu Ala Val Glu
                2005                2010                2015    
Gly Pro Ser Lys Val Asp Ile Gln Thr Glu Asp Leu Glu Asp Gly Thr
            2020                2025                2030        
Cys Lys Val Ser Tyr Phe Pro Thr Val Pro Gly Val Tyr Ile Val Ser
        2035                2040                2045            
Thr Lys Phe Ala Asp Glu His Val Pro Glu Ile Asn Ser Ser Asp Met
    2050                2055                2060                
Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu Ile
2065                2070                2075                2080
Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln Glu
                2085                2090                2095    
Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val Thr
            2100                2105                2110        
Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala
        2115                2120                2125            
His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala Gly
    2130                2135                2140                
Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly
2145                2150                2155                2160
Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe Asp
                2165                2170                2175    
Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu Pro
            2180                2185                2190        
Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro Glu
        2195                2200                2205            
Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg Arg
    2210                2215                2220                
Leu Thr Val Met Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln Pro
2225                2230                2235                2240
Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp Ala
                2245                2250                2255    
Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser Glu
            2260                2265                2270        
Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn Gly
        2275                2280                2285            
Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly Ser
    2290                2295                2300                
Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro Ala
2305                2310                2315                2320
Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly Ile
                2325                2330                2335    
Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr Leu
            2340                2345                2350        
Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu
        2355                2360                2365            
Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro Met Ala Pro Gly Asn
    2370                2375                2380                
Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn His Ile Val Gly Ser
2385                2390                2395                2400
Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu Val Ser Pro Gly Ser
                2405                2410                2415    
Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser Val Thr Arg Ser Ser
            2420                2425                2430        
Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala Ser Ser Asp Ala Ser
        2435                2440                2445            
Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys Ala Phe Val Gly Gln
    2450                2455                2460                
Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala Gly Ser Asn Met Leu
2465                2470                2475                2480
Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val Ser Met
                2485                2490                2495    
Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val Lys Glu
            2500                2505                2510        
Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His Ile Pro
        2515                2520                2525            
Gly Ser Pro Phe His Val Thr Val Pro
    2530                2535        


<210> 5838
<211> 2578
<212> PRT
<213> Homo sapiens

<400> 5838
Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys
 1               5                  10                  15      
Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys
            20                  25                  30          
Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu
        35                  40                  45              
Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg
    50                  55                  60                  
Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val
65                  70                  75                  80  
Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser
                85                  90                  95      
Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly
            100                 105                 110         
Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp
        115                 120                 125             
Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg
    130                 135                 140                 
Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn
145                 150                 155                 160 
Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp
                165                 170                 175     
Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln
            180                 185                 190         
Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp
        195                 200                 205             
Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp
    210                 215                 220                 
Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala
225                 230                 235                 240 
Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys
                245                 250                 255     
Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys
            260                 265                 270         
Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp
        275                 280                 285             
Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln
    290                 295                 300                 
Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu
305                 310                 315                 320 
Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln
                325                 330                 335     
His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly
            340                 345                 350         
Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly
        355                 360                 365             
Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala
    370                 375                 380                 
Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn
385                 390                 395                 400 
Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys
                405                 410                 415     
Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe
            420                 425                 430         
Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu
        435                 440                 445             
Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro
    450                 455                 460                 
Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys
465                 470                 475                 480 
Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly
                485                 490                 495     
Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala
            500                 505                 510         
Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr
        515                 520                 525             
Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly
    530                 535                 540                 
Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His
545                 550                 555                 560 
Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly
                565                 570                 575     
Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala
            580                 585                 590         
Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr
        595                 600                 605             
Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp
    610                 615                 620                 
Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr
625                 630                 635                 640 
Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu
                645                 650                 655     
Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro
            660                 665                 670         
Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu
        675                 680                 685             
Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr
    690                 695                 700                 
Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val
705                 710                 715                 720 
Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile
                725                 730                 735     
Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val
            740                 745                 750         
Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp
        755                 760                 765             
Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp
    770                 775                 780                 
Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile
785                 790                 795                 800 
His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala
                805                 810                 815     
Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala
            820                 825                 830         
Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val
        835                 840                 845             
Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys
    850                 855                 860                 
Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu
865                 870                 875                 880 
Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu
                885                 890                 895     
Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro
            900                 905                 910         
Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro
        915                 920                 925             
Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu
    930                 935                 940                 
Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys
945                 950                 955                 960 
Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys
                965                 970                 975     
Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu
            980                 985                 990         
Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro
        995                 1000                1005            
Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro
    1010                1015                1020                
Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro
1025                1030                1035                1040
Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly
                1045                1050                1055    
Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly
            1060                1065                1070        
Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser
        1075                1080                1085            
Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro
    1090                1095                1100                
Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly
1105                1110                1115                1120
Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val
                1125                1130                1135    
Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly
            1140                1145                1150        
Leu Leu Ser Val Asn Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu
        1155                1160                1165            
Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn
    1170                1175                1180                
Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly
1185                1190                1195                1200
Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe
                1205                1210                1215    
Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys
            1220                1225                1230        
Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr
        1235                1240                1245            
Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp
    1250                1255                1260                
His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys
1265                1270                1275                1280
Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro
                1285                1290                1295    
Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro
            1300                1305                1310        
Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro
        1315                1320                1325            
Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn
    1330                1335                1340                
Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly
1345                1350                1355                1360
Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg
                1365                1370                1375    
Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro
            1380                1385                1390        
Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly
        1395                1400                1405            
Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val
    1410                1415                1420                
Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu
1425                1430                1435                1440
Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu
                1445                1450                1455    
Val Arg Val Leu Gly Pro Arg Gly Leu Val Glu Pro Val Asn Met Val
            1460                1465                1470        
Asp Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu
        1475                1480                1485            
Gly Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg
    1490                1495                1500                
Ser Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val
1505                1510                1515                1520
Thr Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu
                1525                1530                1535    
Pro Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu
            1540                1545                1550        
Ala Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val
        1555                1560                1565            
His Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys
    1570                1575                1580                
Thr Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro
1585                1590                1595                1600
Leu Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys
                1605                1610                1615    
Cys Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu
            1620                1625                1630        
Glu Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val
        1635                1640                1645            
Thr Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val
    1650                1655                1660                
Ile Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys
1665                1670                1675                1680
Pro Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro
                1685                1690                1695    
Asn Ser Pro Phe Thr Val Met Val Thr Glu Glu Ala Tyr Val Pro Val
            1700                1705                1710        
Ser Asp Met Asn Gly Leu Gly Phe Lys Pro Phe Asp Leu Val Ile Pro
        1715                1720                1725            
Phe Ala Val Arg Lys Gly Glu Ile Thr Gly Glu Val His Met Pro Ser
    1730                1735                1740                
Gly Lys Thr Ala Thr Pro Glu Ile Val Asp Asn Lys Asp Gly Thr Val
1745                1750                1755                1760
Thr Val Arg Tyr Ala Pro Thr Glu Val Gly Leu His Glu Met His Ile
                1765                1770                1775    
Lys Tyr Met Gly Ser His Ile Pro Glu Ser Pro Leu Gln Phe Tyr Val
            1780                1785                1790        
Asn Tyr Pro Asn Ser Gly Ser Val Ser Ala Tyr Gly Pro Gly Leu Val
        1795                1800                1805            
Tyr Gly Val Ala Asn Lys Thr Ala Thr Phe Thr Ile Val Thr Glu Asp
    1810                1815                1820                
Ala Gly Glu Gly Gly Leu Asp Leu Ala Ile Glu Gly Pro Ser Lys Ala
1825                1830                1835                1840
Glu Ile Ser Cys Ile Asp Asn Lys Asp Gly Thr Cys Thr Val Thr Tyr
                1845                1850                1855    
Leu Pro Thr Leu Pro Gly Asp Tyr Ser Ile Leu Val Lys Tyr Asn Asp
            1860                1865                1870        
Lys His Ile Pro Gly Ser Pro Phe Thr Ala Lys Ile Thr Asp Asp Ser
        1875                1880                1885            
Arg Arg Cys Ser Gln Val Lys Leu Gly Ser Ala Ala Asp Phe Leu Leu
    1890                1895                1900                
Asp Ile Ser Glu Thr Asp Leu Ser Ser Leu Thr Ala Ser Ile Lys Ala
1905                1910                1915                1920
Pro Ser Gly Arg Asp Glu Pro Cys Leu Leu Lys Arg Leu Pro Asn Asn
                1925                1930                1935    
His Ile Gly Ile Ser Phe Ile Pro Arg Glu Val Gly Glu His Leu Val
            1940                1945                1950        
Ser Ile Lys Lys Asn Gly Asn His Val Ala Asn Ser Pro Val Ser Ile
        1955                1960                1965            
Met Val Val Gln Ser Glu Ile Gly Asp Ala Arg Arg Ala Lys Val Tyr
    1970                1975                1980                
Gly Arg Gly Leu Ser Glu Gly Arg Thr Phe Glu Met Ser Asp Phe Ile
1985                1990                1995                2000
Val Asp Thr Arg Asp Ala Gly Tyr Gly Gly Ile Ser Leu Ala Val Glu
                2005                2010                2015    
Gly Pro Ser Lys Val Asp Ile Gln Thr Glu Asp Leu Glu Asp Gly Thr
            2020                2025                2030        
Cys Lys Val Ser Tyr Phe Pro Thr Val Pro Gly Val Tyr Ile Val Ser
        2035                2040                2045            
Thr Lys Phe Ala Asp Glu His Val Pro Gly Ser Pro Phe Thr Val Lys
    2050                2055                2060                
Ile Ser Gly Glu Gly Arg Val Lys Glu Ser Ile Thr Arg Thr Ser Arg
2065                2070                2075                2080
Ala Pro Ser Val Ala Thr Val Gly Ser Ile Cys Asp Leu Asn Leu Lys
                2085                2090                2095    
Ile Pro Glu Ile Asn Ser Ser Asp Met Ser Ala His Val Thr Ser Pro
            2100                2105                2110        
Ser Gly Arg Val Thr Glu Ala Glu Ile Val Pro Met Gly Lys Asn Ser
        2115                2120                2125            
His Cys Val Arg Phe Val Pro Gln Glu Met Gly Val His Thr Val Ser
    2130                2135                2140                
Val Lys Tyr Arg Gly Gln His Val Thr Gly Ser Pro Phe Gln Phe Thr
2145                2150                2155                2160
Val Gly Pro Leu Gly Glu Gly Gly Ala His Lys Val Arg Ala Gly Gly
                2165                2170                2175    
Pro Gly Leu Glu Arg Gly Glu Ala Gly Val Pro Ala Glu Phe Ser Ile
            2180                2185                2190        
Trp Thr Arg Glu Ala Gly Ala Gly Gly Leu Ser Ile Ala Val Glu Gly
        2195                2200                2205            
Pro Ser Lys Ala Glu Ile Thr Phe Asp Asp His Lys Asn Gly Ser Cys
    2210                2215                2220                
Gly Val Ser Tyr Ile Ala Gln Glu Pro Gly Asn Tyr Glu Val Ser Ile
2225                2230                2235                2240
Lys Phe Asn Asp Glu His Ile Pro Glu Ser Pro Tyr Leu Val Pro Val
                2245                2250                2255    
Ile Ala Pro Ser Asp Asp Ala Arg Arg Leu Thr Val Met Ser Leu Gln
            2260                2265                2270        
Glu Ser Gly Leu Lys Val Asn Gln Pro Ala Ser Phe Ala Ile Arg Leu
        2275                2280                2285            
Asn Gly Ala Lys Gly Lys Ile Asp Ala Lys Val His Ser Pro Ser Gly
    2290                2295                2300                
Ala Val Glu Glu Cys His Val Ser Glu Leu Glu Pro Asp Lys Tyr Ala
2305                2310                2315                2320
Val Arg Phe Ile Pro His Glu Asn Gly Val His Thr Ile Asp Val Lys
                2325                2330                2335    
Phe Asn Gly Ser His Val Val Gly Ser Pro Phe Lys Val Arg Val Gly
            2340                2345                2350        
Glu Pro Gly Gln Ala Gly Asn Pro Ala Leu Val Ser Ala Tyr Gly Thr
        2355                2360                2365            
Gly Leu Glu Gly Gly Thr Thr Gly Ile Gln Ser Glu Phe Phe Ile Asn
    2370                2375                2380                
Thr Thr Arg Ala Gly Pro Gly Thr Leu Ser Val Thr Ile Glu Gly Pro
2385                2390                2395                2400
Ser Lys Val Lys Met Asp Cys Gln Glu Thr Pro Glu Gly Tyr Lys Val
                2405                2410                2415    
Met Tyr Thr Pro Met Ala Pro Gly Asn Tyr Leu Ile Ser Val Lys Tyr
            2420                2425                2430        
Gly Gly Pro Asn His Ile Val Gly Ser Pro Phe Lys Ala Lys Val Thr
        2435                2440                2445            
Gly Gln Arg Leu Val Ser Pro Gly Ser Ala Asn Glu Thr Ser Ser Ile
    2450                2455                2460                
Leu Val Glu Ser Val Thr Arg Ser Ser Thr Glu Thr Cys Tyr Ser Ala
2465                2470                2475                2480
Ile Pro Lys Ala Ser Ser Asp Ala Ser Lys Val Thr Ser Lys Gly Ala
                2485                2490                2495    
Gly Leu Ser Lys Ala Phe Val Gly Gln Lys Ser Ser Phe Leu Val Asp
            2500                2505                2510        
Cys Ser Lys Ala Gly Ser Asn Met Leu Leu Ile Gly Val His Gly Pro
        2515                2520                2525            
Thr Thr Pro Cys Glu Glu Val Ser Met Lys His Val Gly Asn Gln Gln
    2530                2535                2540                
Tyr Asn Val Thr Tyr Val Val Lys Glu Arg Gly Asp Tyr Val Leu Ala
2545                2550                2555                2560
Val Lys Trp Gly Glu Glu His Ile Pro Gly Ser Pro Phe His Val Thr
                2565                2570                2575    
Val Pro
        


<210> 5839
<211> 2561
<212> PRT
<213> Homo sapiens

<400> 5839
Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys
 1               5                  10                  15      
Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys
            20                  25                  30          
Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu
        35                  40                  45              
Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg
    50                  55                  60                  
Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val
65                  70                  75                  80  
Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser
                85                  90                  95      
Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly
            100                 105                 110         
Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp
        115                 120                 125             
Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg
    130                 135                 140                 
Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn
145                 150                 155                 160 
Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp
                165                 170                 175     
Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln
            180                 185                 190         
Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp
        195                 200                 205             
Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp
    210                 215                 220                 
Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala
225                 230                 235                 240 
Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys
                245                 250                 255     
Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys
            260                 265                 270         
Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp
        275                 280                 285             
Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln
    290                 295                 300                 
Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu
305                 310                 315                 320 
Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln
                325                 330                 335     
His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly
            340                 345                 350         
Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly
        355                 360                 365             
Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala
    370                 375                 380                 
Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn
385                 390                 395                 400 
Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys
                405                 410                 415     
Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe
            420                 425                 430         
Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu
        435                 440                 445             
Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro
    450                 455                 460                 
Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys
465                 470                 475                 480 
Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly
                485                 490                 495     
Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala
            500                 505                 510         
Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr
        515                 520                 525             
Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly
    530                 535                 540                 
Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His
545                 550                 555                 560 
Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly
                565                 570                 575     
Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala
            580                 585                 590         
Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr
        595                 600                 605             
Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp
    610                 615                 620                 
Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr
625                 630                 635                 640 
Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu
                645                 650                 655     
Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro
            660                 665                 670         
Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu
        675                 680                 685             
Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr
    690                 695                 700                 
Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val
705                 710                 715                 720 
Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile
                725                 730                 735     
Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val
            740                 745                 750         
Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp
        755                 760                 765             
Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp
    770                 775                 780                 
Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile
785                 790                 795                 800 
His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala
                805                 810                 815     
Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala
            820                 825                 830         
Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val
        835                 840                 845             
Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys
    850                 855                 860                 
Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu
865                 870                 875                 880 
Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu
                885                 890                 895     
Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro
            900                 905                 910         
Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro
        915                 920                 925             
Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu
    930                 935                 940                 
Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys
945                 950                 955                 960 
Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys
                965                 970                 975     
Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu
            980                 985                 990         
Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro
        995                 1000                1005            
Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro
    1010                1015                1020                
Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro
1025                1030                1035                1040
Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly
                1045                1050                1055    
Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly
            1060                1065                1070        
Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser
        1075                1080                1085            
Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro
    1090                1095                1100                
Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly
1105                1110                1115                1120
Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val
                1125                1130                1135    
Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly
            1140                1145                1150        
Leu Leu Ser Val Asn Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu
        1155                1160                1165            
Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn
    1170                1175                1180                
Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly
1185                1190                1195                1200
Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe
                1205                1210                1215    
Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys
            1220                1225                1230        
Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr
        1235                1240                1245            
Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp
    1250                1255                1260                
His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys
1265                1270                1275                1280
Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro
                1285                1290                1295    
Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro
            1300                1305                1310        
Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro
        1315                1320                1325            
Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn
    1330                1335                1340                
Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly
1345                1350                1355                1360
Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg
                1365                1370                1375    
Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro
            1380                1385                1390        
Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly
        1395                1400                1405            
Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val
    1410                1415                1420                
Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu
1425                1430                1435                1440
Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu
                1445                1450                1455    
Val Arg Val Leu Gly Pro Arg Gly Leu Val Glu Pro Val Asn Met Val
            1460                1465                1470        
Asp Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu
        1475                1480                1485            
Gly Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg
    1490                1495                1500                
Ser Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val
1505                1510                1515                1520
Thr Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu
                1525                1530                1535    
Pro Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu
            1540                1545                1550        
Ala Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val
        1555                1560                1565            
His Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys
    1570                1575                1580                
Thr Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro
1585                1590                1595                1600
Leu Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys
                1605                1610                1615    
Cys Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu
            1620                1625                1630        
Glu Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val
        1635                1640                1645            
Thr Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val
    1650                1655                1660                
Ile Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys
1665                1670                1675                1680
Pro Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro
                1685                1690                1695    
Asn Ser Pro Phe Thr Val Met Ala Thr Asp Gly Glu Val Thr Ala Val
            1700                1705                1710        
Glu Glu Ala Pro Val Asn Ala Cys Pro Pro Gly Phe Arg Pro Trp Val
        1715                1720                1725            
Thr Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe
    1730                1735                1740                
Lys Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile
1745                1750                1755                1760
Thr Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile
                1765                1770                1775    
Val Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu
            1780                1785                1790        
Val Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro
        1795                1800                1805            
Glu Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val
    1810                1815                1820                
Ser Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala
1825                1830                1835                1840
Thr Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu
                1845                1850                1855    
Ala Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys
            1860                1865                1870        
Asp Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr
        1875                1880                1885            
Ser Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe
    1890                1895                1900                
Thr Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu
1905                1910                1915                1920
Gly Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser
                1925                1930                1935    
Ser Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys
            1940                1945                1950        
Leu Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro
        1955                1960                1965            
Arg Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His
    1970                1975                1980                
Val Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly
1985                1990                1995                2000
Asp Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg
                2005                2010                2015    
Thr Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr
            2020                2025                2030        
Gly Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln
        2035                2040                2045            
Thr Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr
    2050                2055                2060                
Val Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val
2065                2070                2075                2080
Pro Glu Ile Asn Ser Ser Asp Met Ser Ala His Val Thr Ser Pro Ser
                2085                2090                2095    
Gly Arg Val Thr Glu Ala Glu Ile Val Pro Met Gly Lys Asn Ser His
            2100                2105                2110        
Cys Val Arg Phe Val Pro Gln Glu Met Gly Val His Thr Val Ser Val
        2115                2120                2125            
Lys Tyr Arg Gly Gln His Val Thr Gly Ser Pro Phe Gln Phe Thr Val
    2130                2135                2140                
Gly Pro Leu Gly Glu Gly Gly Ala His Lys Val Arg Ala Gly Gly Pro
2145                2150                2155                2160
Gly Leu Glu Arg Gly Glu Ala Gly Val Pro Ala Glu Phe Ser Ile Trp
                2165                2170                2175    
Thr Arg Glu Ala Gly Ala Gly Gly Leu Ser Ile Ala Val Glu Gly Pro
            2180                2185                2190        
Ser Lys Ala Glu Ile Thr Phe Asp Asp His Lys Asn Gly Ser Cys Gly
        2195                2200                2205            
Val Ser Tyr Ile Ala Gln Glu Pro Gly Asn Tyr Glu Val Ser Ile Lys
    2210                2215                2220                
Phe Asn Asp Glu His Ile Pro Glu Ser Pro Tyr Leu Val Pro Val Ile
2225                2230                2235                2240
Ala Pro Ser Asp Asp Ala Arg Arg Leu Thr Val Met Ser Leu Gln Glu
                2245                2250                2255    
Ser Gly Leu Lys Val Asn Gln Pro Ala Ser Phe Ala Ile Arg Leu Asn
            2260                2265                2270        
Gly Ala Lys Gly Lys Ile Asp Ala Lys Val His Ser Pro Ser Gly Ala
        2275                2280                2285            
Val Glu Glu Cys His Val Ser Glu Leu Glu Pro Asp Lys Tyr Ala Val
    2290                2295                2300                
Arg Phe Ile Pro His Glu Asn Gly Val His Thr Ile Asp Val Lys Phe
2305                2310                2315                2320
Asn Gly Ser His Val Val Gly Ser Pro Phe Lys Val Arg Val Gly Glu
                2325                2330                2335    
Pro Gly Gln Ala Gly Asn Pro Ala Leu Val Ser Ala Tyr Gly Thr Gly
            2340                2345                2350        
Leu Glu Gly Gly Thr Thr Gly Ile Gln Ser Glu Phe Phe Ile Asn Thr
        2355                2360                2365            
Thr Arg Ala Gly Pro Gly Thr Leu Ser Val Thr Ile Glu Gly Pro Ser
    2370                2375                2380                
Lys Val Lys Met Asp Cys Gln Glu Thr Pro Glu Gly Tyr Lys Val Met
2385                2390                2395                2400
Tyr Thr Pro Met Ala Pro Gly Asn Tyr Leu Ile Ser Val Lys Tyr Gly
                2405                2410                2415    
Gly Pro Asn His Ile Val Gly Ser Pro Phe Lys Ala Lys Val Thr Gly
            2420                2425                2430        
Gln Arg Leu Val Ser Pro Gly Ser Ala Asn Glu Thr Ser Ser Ile Leu
        2435                2440                2445            
Val Glu Ser Val Thr Arg Ser Ser Thr Glu Thr Cys Tyr Ser Ala Ile
    2450                2455                2460                
Pro Lys Ala Ser Ser Asp Ala Ser Lys Val Thr Ser Lys Gly Ala Gly
2465                2470                2475                2480
Leu Ser Lys Ala Phe Val Gly Gln Lys Ser Ser Phe Leu Val Asp Cys
                2485                2490                2495    
Ser Lys Ala Gly Ser Asn Met Leu Leu Ile Gly Val His Gly Pro Thr
            2500                2505                2510        
Thr Pro Cys Glu Glu Val Ser Met Lys His Val Gly Asn Gln Gln Tyr
        2515                2520                2525            
Asn Val Thr Tyr Val Val Lys Glu Arg Gly Asp Tyr Val Leu Ala Val
    2530                2535                2540                
Lys Trp Gly Glu Glu His Ile Pro Gly Ser Pro Phe His Val Thr Val
2545                2550                2555                2560
Pro
    


<210> 5840
<211> 91
<212> PRT
<213> Homo sapiens

<400> 5840
Met Pro Leu Ile Ala Thr Ser Ser Gln Gly Leu Ser Lys Ala Phe Val
 1               5                  10                  15      
Gly Gln Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala Ser Ser Asn
            20                  25                  30          
Met Leu Leu Ile Arg Val His Gly Pro Thr Thr Ala Cys Glu Lys Val
        35                  40                  45              
Ser Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val
    50                  55                  60                  
Lys Glu Arg Gly His Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His
65                  70                  75                  80  
Ile Pro Gly Ser Pro Phe His Val Thr Val Pro
                85                  90      


<210> 5841
<211> 2602
<212> PRT
<213> Homo sapiens

<400> 5841
Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys
 1               5                  10                  15      
Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys
            20                  25                  30          
Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu
        35                  40                  45              
Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg
    50                  55                  60                  
Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val
65                  70                  75                  80  
Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser
                85                  90                  95      
Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly
            100                 105                 110         
Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp
        115                 120                 125             
Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg
    130                 135                 140                 
Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn
145                 150                 155                 160 
Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp
                165                 170                 175     
Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln
            180                 185                 190         
Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp
        195                 200                 205             
Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp
    210                 215                 220                 
Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala
225                 230                 235                 240 
Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys
                245                 250                 255     
Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys
            260                 265                 270         
Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp
        275                 280                 285             
Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln
    290                 295                 300                 
Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu
305                 310                 315                 320 
Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln
                325                 330                 335     
His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly
            340                 345                 350         
Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly
        355                 360                 365             
Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala
    370                 375                 380                 
Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn
385                 390                 395                 400 
Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys
                405                 410                 415     
Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe
            420                 425                 430         
Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu
        435                 440                 445             
Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro
    450                 455                 460                 
Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys
465                 470                 475                 480 
Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly
                485                 490                 495     
Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala
            500                 505                 510         
Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr
        515                 520                 525             
Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly
    530                 535                 540                 
Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His
545                 550                 555                 560 
Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly
                565                 570                 575     
Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala
            580                 585                 590         
Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr
        595                 600                 605             
Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp
    610                 615                 620                 
Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr
625                 630                 635                 640 
Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu
                645                 650                 655     
Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro
            660                 665                 670         
Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu
        675                 680                 685             
Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr
    690                 695                 700                 
Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val
705                 710                 715                 720 
Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile
                725                 730                 735     
Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val
            740                 745                 750         
Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp
        755                 760                 765             
Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp
    770                 775                 780                 
Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile
785                 790                 795                 800 
His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala
                805                 810                 815     
Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala
            820                 825                 830         
Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val
        835                 840                 845             
Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys
    850                 855                 860                 
Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu
865                 870                 875                 880 
Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu
                885                 890                 895     
Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro
            900                 905                 910         
Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro
        915                 920                 925             
Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu
    930                 935                 940                 
Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys
945                 950                 955                 960 
Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys
                965                 970                 975     
Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu
            980                 985                 990         
Val Thr Pro Val Thr Gly Arg Glu Asn Ser Thr Ala Lys Phe Ile Pro
        995                 1000                1005            
Arg Glu Glu Gly Leu Tyr Ala Val Asp Val Thr Tyr Asp Gly His Pro
    1010                1015                1020                
Val Pro Gly Ser Pro Tyr Thr Val Glu Ala Ser Leu Pro Pro Asp Pro
1025                1030                1035                1040
Ser Lys Val Lys Ala His Gly Pro Gly Leu Glu Gly Gly Leu Val Gly
                1045                1050                1055    
Lys Pro Ala Glu Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly
            1060                1065                1070        
Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu Cys Ser
        1075                1080                1085            
Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Thr Lys Pro
    1090                1095                1100                
Gly Glu Tyr Phe Val Asn Ile Leu Phe Glu Glu Val His Ile Pro Gly
1105                1110                1115                1120
Ser Pro Phe Lys Ala Asp Ile Glu Met Pro Phe Asp Pro Ser Lys Val
                1125                1130                1135    
Val Ala Ser Gly Pro Gly Leu Glu His Gly Lys Val Gly Glu Ala Gly
            1140                1145                1150        
Leu Leu Ser Val Asn Cys Ser Glu Ala Gly Pro Gly Ala Leu Gly Leu
        1155                1160                1165            
Glu Ala Val Ser Asp Ser Gly Thr Lys Ala Glu Val Ser Ile Gln Asn
    1170                1175                1180                
Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Val Pro Leu Thr Ala Gly
1185                1190                1195                1200
Met Tyr Thr Leu Thr Met Lys Tyr Gly Gly Glu Leu Val Pro His Phe
                1205                1210                1215    
Pro Ala Arg Val Lys Val Glu Pro Ala Val Asp Thr Ser Arg Ile Lys
            1220                1225                1230        
Val Phe Gly Pro Gly Ile Glu Gly Lys Asp Val Phe Arg Glu Ala Thr
        1235                1240                1245            
Thr Asp Phe Thr Val Asp Ser Arg Pro Leu Thr Gln Val Gly Gly Asp
    1250                1255                1260                
His Ile Lys Ala His Ile Ala Asn Pro Ser Gly Ala Ser Thr Glu Cys
1265                1270                1275                1280
Phe Val Thr Asp Asn Ala Asp Gly Thr Tyr Gln Val Glu Tyr Thr Pro
                1285                1290                1295    
Phe Glu Lys Gly Leu His Val Val Glu Val Thr Tyr Asp Asp Val Pro
            1300                1305                1310        
Ile Pro Asn Ser Pro Phe Lys Val Ala Val Thr Glu Gly Cys Gln Pro
        1315                1320                1325            
Ser Arg Val Gln Ala Gln Gly Pro Gly Leu Lys Glu Ala Phe Thr Asn
    1330                1335                1340                
Lys Pro Asn Val Phe Thr Val Val Thr Arg Gly Ala Gly Ile Gly Gly
1345                1350                1355                1360
Leu Gly Ile Thr Val Glu Gly Pro Ser Glu Ser Lys Ile Asn Cys Arg
                1365                1370                1375    
Asp Asn Lys Asp Gly Ser Cys Ser Ala Glu Tyr Ile Pro Phe Ala Pro
            1380                1385                1390        
Gly Asp Tyr Asp Val Asn Ile Thr Tyr Gly Gly Ala His Ile Pro Gly
        1395                1400                1405            
Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Ser Lys Val
    1410                1415                1420                
Lys Ile Ala Gly Pro Gly Leu Gly Ser Gly Val Arg Ala Arg Val Leu
1425                1430                1435                1440
Gln Ser Phe Thr Val Asp Ser Ser Lys Ala Gly Leu Ala Pro Leu Glu
                1445                1450                1455    
Val Arg Val Leu Gly Pro Arg Gly Leu Val Glu Pro Val Asn Met Val
            1460                1465                1470        
Asp Asn Gly Asp Gly Thr His Thr Val Thr Tyr Thr Pro Ser Gln Glu
        1475                1480                1485            
Gly Pro Tyr Met Val Ser Val Lys Tyr Ala Asp Glu Glu Ile Pro Arg
    1490                1495                1500                
Ser Pro Phe Lys Val Lys Val Leu Pro Thr Tyr Asp Ala Ser Lys Val
1505                1510                1515                1520
Thr Ala Ser Gly Pro Gly Leu Ser Ser Tyr Gly Val Pro Ala Ser Leu
                1525                1530                1535    
Pro Val Asp Phe Ala Ile Asp Ala Arg Asp Ala Gly Glu Gly Leu Leu
            1540                1545                1550        
Ala Val Gln Ile Thr Asp Gln Glu Gly Lys Pro Lys Arg Ala Ile Val
        1555                1560                1565            
His Asp Asn Lys Asp Gly Thr Tyr Ala Val Thr Tyr Ile Pro Asp Lys
    1570                1575                1580                
Thr Gly Arg Tyr Met Ile Gly Val Thr Tyr Gly Gly Asp Asp Ile Pro
1585                1590                1595                1600
Leu Ser Pro Tyr Arg Ile Arg Ala Thr Gln Thr Gly Asp Ala Ser Lys
                1605                1610                1615    
Cys Leu Ala Thr Gly Pro Gly Ile Ala Ser Thr Val Lys Thr Gly Glu
            1620                1625                1630        
Glu Val Gly Phe Val Val Asp Ala Lys Thr Ala Gly Lys Gly Lys Val
        1635                1640                1645            
Thr Cys Thr Val Leu Thr Pro Asp Gly Thr Glu Ala Glu Ala Asp Val
    1650                1655                1660                
Ile Glu Asn Glu Asp Gly Thr Tyr Asp Ile Phe Tyr Thr Ala Ala Lys
1665                1670                1675                1680
Pro Gly Thr Tyr Val Ile Tyr Val Arg Phe Gly Gly Val Asp Ile Pro
                1685                1690                1695    
Asn Ser Pro Phe Thr Val Met Ala Thr Asp Gly Glu Val Thr Ala Val
            1700                1705                1710        
Glu Glu Ala Pro Val Asn Ala Cys Pro Pro Gly Phe Arg Pro Trp Val
        1715                1720                1725            
Thr Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe
    1730                1735                1740                
Lys Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile
1745                1750                1755                1760
Thr Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile
                1765                1770                1775    
Val Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu
            1780                1785                1790        
Val Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro
        1795                1800                1805            
Glu Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val
    1810                1815                1820                
Ser Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala
1825                1830                1835                1840
Thr Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu
                1845                1850                1855    
Ala Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys
            1860                1865                1870        
Asp Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr
        1875                1880                1885            
Ser Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe
    1890                1895                1900                
Thr Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu
1905                1910                1915                1920
Gly Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser
                1925                1930                1935    
Ser Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys
            1940                1945                1950        
Leu Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro
        1955                1960                1965            
Arg Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His
    1970                1975                1980                
Val Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly
1985                1990                1995                2000
Asp Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg
                2005                2010                2015    
Thr Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr
            2020                2025                2030        
Gly Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln
        2035                2040                2045            
Thr Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr
    2050                2055                2060                
Val Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val
2065                2070                2075                2080
Pro Gly Ser Pro Phe Thr Val Lys Ile Ser Gly Glu Gly Arg Val Lys
                2085                2090                2095    
Glu Ser Ile Thr Arg Thr Ser Arg Ala Pro Ser Val Ala Thr Val Gly
            2100                2105                2110        
Ser Ile Cys Asp Leu Asn Leu Lys Ile Pro Glu Ile Asn Ser Ser Asp
        2115                2120                2125            
Met Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu
    2130                2135                2140                
Ile Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln
2145                2150                2155                2160
Glu Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val
                2165                2170                2175    
Thr Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly
            2180                2185                2190        
Ala His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala
        2195                2200                2205            
Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly
    2210                2215                2220                
Gly Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe
2225                2230                2235                2240
Asp Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu
                2245                2250                2255    
Pro Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro
            2260                2265                2270        
Glu Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg
        2275                2280                2285            
Arg Leu Thr Val Met Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln
    2290                2295                2300                
Pro Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp
2305                2310                2315                2320
Ala Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser
                2325                2330                2335    
Glu Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn
            2340                2345                2350        
Gly Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly
        2355                2360                2365            
Ser Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro
    2370                2375                2380                
Ala Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly
2385                2390                2395                2400
Ile Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr
                2405                2410                2415    
Leu Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln
            2420                2425                2430        
Glu Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro Met Ala Pro Gly
        2435                2440                2445            
Asn Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn His Ile Val Gly
    2450                2455                2460                
Ser Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu Val Ser Pro Gly
2465                2470                2475                2480
Ser Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser Val Thr Arg Ser
                2485                2490                2495    
Ser Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala Ser Ser Asp Ala
            2500                2505                2510        
Ser Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys Ala Phe Val Gly
        2515                2520                2525            
Gln Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala Gly Ser Asn Met
    2530                2535                2540                
Leu Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val Ser
2545                2550                2555                2560
Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val Lys
                2565                2570                2575    
Glu Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His Ile
            2580                2585                2590        
Pro Gly Ser Pro Phe His Val Thr Val Pro
        2595                2600        


<210> 5842
<211> 194
<212> PRT
<213> Homo sapiens

<400> 5842
Met Tyr Thr Pro Met Ala Pro Gly Asn Tyr Leu Ile Ser Val Lys Tyr
 1               5                  10                  15      
Gly Gly Pro Asn His Ile Val Gly Ser Pro Phe Lys Ala Lys Val Thr
            20                  25                  30          
Gly Gln Arg Leu Val Ser Pro Gly Ser Ala Asn Glu Thr Ser Ser Ile
        35                  40                  45              
Leu Val Glu Ser Val Thr Arg Ser Ser Thr Glu Thr Cys Tyr Ser Ala
    50                  55                  60                  
Ile Pro Lys Ala Ser Ser Asp Ala Ser Lys Val Thr Ser Lys Gly Ala
65                  70                  75                  80  
Gly Leu Ser Lys Ala Phe Val Gly Gln Lys Ser Ser Phe Leu Val Asp
                85                  90                  95      
Cys Ser Lys Ala Gly Ser Asn Met Leu Leu Ile Gly Val His Gly Pro
            100                 105                 110         
Thr Thr Pro Cys Glu Glu Val Ser Met Lys His Val Gly Asn Gln Gln
        115                 120                 125             
Tyr Asn Val Thr Tyr Val Val Lys Glu Arg Gly Asp Tyr Val Leu Ala
    130                 135                 140                 
Val Lys Trp Gly Asn Thr Ser Leu Ala Ala Leu Phe Met Ser Gln Cys
145                 150                 155                 160 
Leu Lys Thr Val Phe Ser Asn Pro Gly Glu Ser Ser Cys Gly Cys Phe
                165                 170                 175     
Cys Cys Leu Phe Val Ile His Phe Ile Gln Ser Pro Pro Ala Cys Leu
            180                 185                 190         
Trp Gly
        


<210> 5843
<211> 606
<212> PRT
<213> Homo sapiens

<400> 5843
Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu Ala
 1               5                  10                  15      
Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys
            20                  25                  30          
Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu
        35                  40                  45              
Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu
    50                  55                  60                  
Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser Tyr
65                  70                  75                  80  
Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val
                85                  90                  95      
Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu
            100                 105                 110         
Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu
        115                 120                 125             
Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu
    130                 135                 140                 
Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val
145                 150                 155                 160 
Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu
                165                 170                 175     
Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val
            180                 185                 190         
Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His Leu
        195                 200                 205             
Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu
    210                 215                 220                 
Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met
225                 230                 235                 240 
Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Val
                245                 250                 255     
Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu
            260                 265                 270         
Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile
        275                 280                 285             
Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile
    290                 295                 300                 
Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu
305                 310                 315                 320 
Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu
                325                 330                 335     
Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile
            340                 345                 350         
Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu Gln
        355                 360                 365             
Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly
    370                 375                 380                 
Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala
385                 390                 395                 400 
Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys
                405                 410                 415     
Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys
            420                 425                 430         
Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg
        435                 440                 445             
Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly
    450                 455                 460                 
Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met
465                 470                 475                 480 
Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala
                485                 490                 495     
Ser Leu Thr Val Lys Gly Phe Ala Ser Asp Arg Phe Leu Tyr Ala Asn
            500                 505                 510         
Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Ile Ser Asn Gly
        515                 520                 525             
Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser
    530                 535                 540                 
Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe
545                 550                 555                 560 
Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser
                565                 570                 575     
Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val Glu
            580                 585                 590         
Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile
        595                 600                 605     


<210> 5844
<211> 1317
<212> PRT
<213> Homo sapiens

<400> 5844
Met Ala Ser Thr Pro Lys Glu Glu His Cys Tyr Leu Leu His Ser Phe
 1               5                  10                  15      
Glu Glu Phe Glu Ala Leu Ala Arg Arg Ala Leu His Glu Asp Leu Pro
            20                  25                  30          
Ser Gly Ser Phe Ile Gln Asp Asp Met Val His Cys Ser Tyr Leu Cys
        35                  40                  45              
Asp Glu Gly Lys Asp Cys Cys Asp Arg Met Gly Ser Cys Lys Cys Gly
    50                  55                  60                  
Thr His Thr Gly His Phe Glu Cys Ile Cys Glu Lys Gly Tyr Tyr Gly
65                  70                  75                  80  
Lys Gly Leu Gln Tyr Glu Cys Thr Ala Cys Pro Ser Gly Thr Tyr Lys
                85                  90                  95      
Pro Glu Gly Ser Pro Gly Gly Ile Ser Ser Cys Ile Pro Cys Pro Asp
            100                 105                 110         
Glu Asn His Thr Ser Pro Pro Gly Ser Thr Ser Pro Glu Asp Cys Val
        115                 120                 125             
Cys Arg Glu Gly Tyr Arg Ala Ser Gly Gln Thr Cys Glu Leu Val His
    130                 135                 140                 
Cys Pro Ala Leu Lys Pro Pro Glu Asn Gly Tyr Phe Ile Gln Asn Thr
145                 150                 155                 160 
Cys Asn Asn His Phe Asn Ala Ala Cys Gly Val Arg Cys His Pro Gly
                165                 170                 175     
Phe Asp Leu Val Gly Ser Ser Ile Ile Leu Cys Leu Pro Asn Gly Leu
            180                 185                 190         
Trp Ser Gly Ser Glu Ser Tyr Cys Arg Val Arg Thr Cys Pro His Leu
        195                 200                 205             
Arg Gln Pro Lys His Gly His Ile Ser Cys Ser Thr Arg Glu Met Leu
    210                 215                 220                 
Tyr Lys Thr Thr Cys Leu Val Ala Cys Asp Glu Gly Tyr Arg Leu Glu
225                 230                 235                 240 
Gly Ser Asp Lys Leu Thr Cys Gln Gly Asn Ser Gln Trp Asp Gly Pro
                245                 250                 255     
Glu Pro Arg Cys Val Glu Arg His Cys Ser Thr Phe Gln Met Pro Lys
            260                 265                 270         
Asp Val Ile Ile Ser Pro His Asn Cys Gly Lys Gln Pro Ala Lys Phe
        275                 280                 285             
Gly Thr Ile Cys Tyr Val Ser Cys Arg Gln Gly Phe Ile Leu Ser Gly
    290                 295                 300                 
Val Lys Glu Met Leu Arg Cys Thr Thr Ser Gly Lys Trp Asn Val Gly
305                 310                 315                 320 
Val Gln Ala Ala Val Cys Lys Asp Val Glu Ala Pro Gln Ile Asn Cys
                325                 330                 335     
Pro Lys Asp Ile Glu Ala Lys Thr Leu Glu Gln Gln Asp Ser Ala Asn
            340                 345                 350         
Val Thr Trp Gln Ile Pro Thr Ala Lys Asp Asn Ser Gly Glu Lys Val
        355                 360                 365             
Ser Val His Val His Pro Ala Phe Thr Pro Pro Tyr Leu Phe Pro Ile
    370                 375                 380                 
Gly Asp Val Ala Ile Val Tyr Thr Ala Thr Asp Leu Ser Gly Asn Gln
385                 390                 395                 400 
Ala Ser Cys Ile Phe His Ile Lys Val Ile Asp Ala Glu Pro Pro Val
                405                 410                 415     
Ile Asp Trp Cys Arg Ser Pro Pro Pro Val Gln Val Ser Glu Lys Val
            420                 425                 430         
His Ala Ala Ser Trp Asp Glu Pro Gln Phe Ser Asp Asn Ser Gly Ala
        435                 440                 445             
Glu Leu Val Ile Thr Arg Ser His Thr Gln Gly Asp Leu Phe Pro Gln
    450                 455                 460                 
Gly Glu Thr Ile Val Gln Tyr Thr Ala Thr Asp Pro Ser Gly Asn Asn
465                 470                 475                 480 
Arg Thr Cys Asp Ile His Ile Val Ile Lys Gly Ser Pro Cys Glu Ile
                485                 490                 495     
Pro Phe Thr Pro Val Asn Gly Asp Phe Ile Cys Thr Pro Asp Asn Thr
            500                 505                 510         
Gly Val Asn Cys Thr Leu Thr Cys Leu Glu Gly Tyr Asp Phe Thr Glu
        515                 520                 525             
Gly Ser Thr Asp Lys Tyr Tyr Cys Ala Tyr Glu Asp Gly Val Trp Lys
    530                 535                 540                 
Pro Thr Tyr Thr Thr Glu Trp Pro Asp Cys Ala Lys Lys Arg Phe Ala
545                 550                 555                 560 
Asn His Gly Phe Lys Ser Phe Glu Met Phe Tyr Lys Ala Ala Arg Cys
                565                 570                 575     
Asp Asp Thr Asp Leu Met Lys Lys Phe Ser Glu Ala Phe Glu Thr Thr
            580                 585                 590         
Leu Gly Lys Met Val Pro Ser Phe Cys Ser Asp Ala Glu Asp Ile Asp
        595                 600                 605             
Cys Arg Leu Glu Glu Asn Leu Thr Lys Lys Tyr Cys Leu Glu Tyr Asn
    610                 615                 620                 
Tyr Asp Tyr Glu Asn Gly Phe Ala Ile Gly Pro Gly Gly Trp Gly Ala
625                 630                 635                 640 
Ala Asn Arg Leu Asp Tyr Ser Tyr Asp Asp Phe Leu Asp Thr Val Gln
                645                 650                 655     
Glu Thr Ala Thr Ser Ile Gly Asn Ala Lys Ser Ser Arg Ile Lys Arg
            660                 665                 670         
Ser Ala Pro Leu Ser Asp Tyr Lys Ile Lys Leu Ile Phe Asn Ile Thr
        675                 680                 685             
Ala Ser Val Pro Leu Pro Asp Glu Arg Asn Asp Thr Leu Glu Trp Glu
    690                 695                 700                 
Asn Gln Gln Arg Leu Leu Gln Thr Leu Glu Thr Ile Thr Asn Lys Leu
705                 710                 715                 720 
Lys Arg Thr Leu Asn Lys Asp Pro Met Tyr Ser Phe Gln Leu Ala Ser
                725                 730                 735     
Glu Ile Leu Ile Ala Asp Ser Asn Ser Leu Glu Thr Lys Lys Ala Ser
            740                 745                 750         
Pro Phe Cys Arg Pro Gly Ser Val Leu Arg Gly Arg Met Cys Val Asn
        755                 760                 765             
Cys Pro Leu Gly Thr Tyr Tyr Asn Leu Glu His Phe Thr Cys Glu Ser
    770                 775                 780                 
Cys Arg Ile Gly Ser Tyr Gln Asp Glu Glu Gly Gln Leu Glu Cys Lys
785                 790                 795                 800 
Leu Cys Pro Ser Gly Met Tyr Thr Glu Tyr Ile His Ser Arg Asn Ile
                805                 810                 815     
Ser Asp Cys Lys Ala Gln Cys Lys Gln Gly Thr Tyr Ser Tyr Ser Gly
            820                 825                 830         
Leu Glu Thr Cys Glu Ser Cys Pro Leu Gly Thr Tyr Gln Pro Lys Phe
        835                 840                 845             
Gly Ser Arg Ser Cys Leu Ser Cys Pro Glu Asn Thr Ser Thr Val Lys
    850                 855                 860                 
Arg Gly Ala Val Asn Ile Ser Ala Cys Gly Val Pro Cys Pro Glu Gly
865                 870                 875                 880 
Lys Phe Ser Arg Ser Gly Leu Met Pro Cys His Pro Cys Pro Arg Asp
                885                 890                 895     
Tyr Tyr Gln Pro Asn Ala Gly Lys Ala Phe Cys Leu Ala Cys Pro Phe
            900                 905                 910         
Tyr Gly Thr Thr Pro Phe Ala Gly Ser Arg Ser Ile Thr Glu Cys Ser
        915                 920                 925             
Ser Phe Ser Ser Thr Phe Ser Ala Ala Glu Glu Ser Val Val Pro Pro
    930                 935                 940                 
Ala Ser Leu Gly His Ile Lys Lys Arg His Glu Ile Ser Ser Gln Ala
945                 950                 955                 960 
Ser Phe His Glu Cys Phe Phe Asn Pro Cys His Asn Ser Gly Thr Cys
                965                 970                 975     
Gln Gln Leu Gly Arg Gly Tyr Val Cys Leu Cys Pro Leu Gly Tyr Thr
            980                 985                 990         
Gly Leu Lys Cys Glu Thr Asp Ile Asp Glu Cys Ser Pro Leu Pro Cys
        995                 1000                1005            
Leu Asn Asn Gly Val Cys Lys Asp Leu Val Gly Glu Phe Ile Cys Glu
    1010                1015                1020                
Cys Pro Ser Gly Tyr Thr Gly Gln Arg Cys Glu Glu Asn Ile Asn Glu
1025                1030                1035                1040
Cys Ser Ser Ser Pro Cys Leu Asn Lys Gly Ile Cys Val Asp Gly Val
                1045                1050                1055    
Ala Gly Tyr Arg Cys Thr Cys Val Lys Gly Phe Val Gly Leu His Cys
            1060                1065                1070        
Glu Thr Glu Val Asn Glu Cys Gln Ser Asn Pro Cys Leu Asn Asn Ala
        1075                1080                1085            
Val Cys Glu Asp Gln Val Gly Gly Phe Leu Cys Lys Cys Pro Pro Gly
    1090                1095                1100                
Phe Leu Gly Thr Arg Cys Gly Lys Asn Val Asp Glu Cys Leu Ser Gln
1105                1110                1115                1120
Pro Cys Lys Asn Gly Ala Thr Cys Lys Asp Gly Ala Asn Ser Phe Arg
                1125                1130                1135    
Cys Leu Cys Ala Ala Gly Phe Thr Gly Ser His Cys Glu Leu Asn Ile
            1140                1145                1150        
Asn Glu Cys Gln Ser Asn Pro Cys Arg Asn Gln Ala Thr Cys Val Asp
        1155                1160                1165            
Glu Leu Asn Ser Tyr Ser Cys Lys Cys Gln Pro Gly Phe Ser Gly Lys
    1170                1175                1180                
Arg Cys Glu Thr Glu Gln Ser Thr Gly Phe Asn Leu Asp Phe Glu Val
1185                1190                1195                1200
Ser Gly Ile Tyr Gly Tyr Val Met Leu Asp Gly Met Leu Pro Ser Leu
                1205                1210                1215    
His Ala Leu Thr Cys Thr Phe Trp Met Lys Ser Ser Asp Asp Met Asn
            1220                1225                1230        
Tyr Gly Thr Pro Ile Ser Tyr Ala Val Asp Asn Gly Ser Asp Asn Thr
        1235                1240                1245            
Leu Leu Leu Thr Asp Tyr Asn Gly Trp Val Leu Tyr Val Asn Gly Arg
    1250                1255                1260                
Glu Lys Ile Thr Asn Cys Pro Ser Val Asn Asp Gly Arg Trp His His
1265                1270                1275                1280
Ile Ala Ile Thr Trp Thr Ser Ala Asn Gly Ile Trp Lys Val Tyr Ile
                1285                1290                1295    
Asp Gly Lys Leu Ser Asp Gly Gly Ala Gly Leu Ser Val Gly Leu Pro
            1300                1305                1310        
Ile Pro Gly Met Phe
        1315        


<210> 5845
<211> 925
<212> PRT
<213> Homo sapiens

<400> 5845
Ala Ala Pro Leu Pro Met Asn Ser Met Asn Pro Met Lys Pro Ala Leu
 1               5                  10                  15      
Pro Pro Ala Pro His Gly Asp Gly Ser Phe Ala Tyr Glu Ser Val Pro
            20                  25                  30          
Trp Gln Gln Ser Ala Thr Gln Pro Ala Gly Ser Leu Ser Val Val Thr
        35                  40                  45              
Thr Val Trp Gly Val Gly Asn Ala Thr Gln Ser Gln Val Leu Gly Asn
    50                  55                  60                  
Pro Met Gly Pro Ala Gly Ser Pro Ser Gly Ser Ser Met Met Pro Gly
65                  70                  75                  80  
Val Ala Gly Gly Ser Ser Ala Leu Thr Ser Pro Gln Cys Leu Gly Gln
                85                  90                  95      
Gln Ala Phe Ala Glu Gly Gly Ala Asn Lys Gly Tyr Val Gln Gln Gly
            100                 105                 110         
Val Tyr Ser Arg Gly Gly Tyr Pro Gly Ala Pro Gly Phe Thr Thr Gly
        115                 120                 125             
Tyr Ala Gly Gly Pro Gly Gly Leu Gly Leu Pro Ser His Ala Ala Arg
    130                 135                 140                 
Pro Ser Thr Asp Phe Thr Gln Ala Ala Ala Ala Ala Ala Val Ala Ala
145                 150                 155                 160 
Ala Ala Ala Thr Ala Thr Ala Thr Ala Thr Ala Thr Val Ala Ala Leu
                165                 170                 175     
Gln Glu Lys Gln Ser Gln Glu Leu Ser Gln Tyr Gly Ala Met Gly Ala
            180                 185                 190         
Gly Gln Ser Phe Asn Ser Gln Phe Leu Gln His Gly Gly Pro Arg Gly
        195                 200                 205             
Pro Ser Val Pro Ala Gly Met Asn Pro Thr Gly Ile Gly Gly Val Met
    210                 215                 220                 
Gly Pro Ser Gly Leu Ser Pro Leu Ala Met Asn Pro Thr Arg Ala Ala
225                 230                 235                 240 
Gly Met Thr Pro Leu Tyr Ala Gly Gln Arg Leu Pro Gln His Gly Tyr
                245                 250                 255     
Pro Gly Pro Pro Gln Ala Gln Pro Leu Pro Arg Gln Gly Val Lys Arg
            260                 265                 270         
Thr Tyr Ser Glu Val Tyr Pro Gly Gln Gln Tyr Leu Gln Gly Gly Gln
        275                 280                 285             
Tyr Ala Pro Ser Thr Ala Gln Phe Ala Pro Ser Pro Gly Gln Pro Pro
    290                 295                 300                 
Ala Pro Ser Pro Ser Tyr Pro Gly His Arg Leu Pro Leu Gln Gln Gly
305                 310                 315                 320 
Met Thr Gln Ser Leu Ser Val Pro Gly Pro Thr Gly Leu His Tyr Lys
                325                 330                 335     
Pro Thr Glu Gln Phe Asn Gly Gln Gly Ala Ser Phe Asn Gly Gly Ser
            340                 345                 350         
Val Ser Tyr Ser Gln Pro Gly Leu Ser Gly Pro Thr Arg Ser Ile Pro
        355                 360                 365             
Gly Tyr Pro Ser Ser Pro Leu Pro Gly Asn Pro Thr Pro Pro Met Thr
    370                 375                 380                 
Pro Ser Ser Ser Val Pro Tyr Met Ser Pro Asn Gln Glu Val Lys Ser
385                 390                 395                 400 
Pro Phe Leu Pro Asp Leu Lys Pro Asn Leu Asn Ser Phe His Ser Ser
                405                 410                 415     
Pro Ser Gly Ser Gly Pro Cys Asp Glu Leu Arg Leu Thr Phe Pro Val
            420                 425                 430         
Arg Asp Gly Val Val Leu Glu Pro Phe Arg Leu Gln His Asn Leu Ala
        435                 440                 445             
Val Ser Asn His Val Phe Gln Leu Arg Asp Ser Val Tyr Lys Thr Leu
    450                 455                 460                 
Ile Met Arg Pro Asp Leu Glu Leu Gln Phe Lys Cys Tyr His His Glu
465                 470                 475                 480 
Asp Arg Gln Met Asn Thr Asn Trp Pro Ala Ser Val Gln Val Ser Val
                485                 490                 495     
Asn Ala Thr Pro Leu Thr Ile Glu Arg Gly Asp Asn Lys Thr Ser His
            500                 505                 510         
Lys Pro Leu Tyr Leu Lys His Val Cys Gln Pro Gly Arg Asn Thr Ile
        515                 520                 525             
Gln Ile Thr Val Thr Ala Cys Cys Cys Ser His Leu Phe Val Leu Gln
    530                 535                 540                 
Leu Val His Arg Pro Ser Val Arg Ser Val Leu Gln Gly Leu Leu Lys
545                 550                 555                 560 
Lys Arg Leu Leu Pro Ala Glu His Cys Ile Thr Lys Ile Lys Arg Asn
                565                 570                 575     
Phe Ser Ser Gly Thr Ile Pro Gly Thr Pro Gly Pro Asn Gly Glu Asp
            580                 585                 590         
Gly Val Glu Gln Thr Ala Ile Lys Val Ser Leu Lys Cys Pro Ile Thr
        595                 600                 605             
Phe Arg Arg Ile Gln Leu Pro Ala Arg Gly His Asp Cys Arg His Ile
    610                 615                 620                 
Gln Cys Phe Asp Leu Glu Ser Tyr Leu Gln Leu Asn Cys Glu Arg Gly
625                 630                 635                 640 
Thr Trp Arg Cys Pro Val Cys Asn Lys Thr Ala Leu Leu Glu Gly Leu
                645                 650                 655     
Glu Val Asp Gln Tyr Met Leu Gly Ile Leu Ile Tyr Ile Gln Asn Ser
            660                 665                 670         
Asp Tyr Glu Glu Ile Thr Ile Asp Pro Thr Cys Ser Trp Lys Pro Val
        675                 680                 685             
Pro Val Lys Pro Asp Met His Ile Lys Glu Glu Pro Asp Gly Pro Ala
    690                 695                 700                 
Leu Lys Arg Cys Arg Thr Val Ser Pro Ala His Val Leu Met Pro Ser
705                 710                 715                 720 
Val Met Glu Met Ile Ala Ala Leu Gly Pro Gly Ala Ala Pro Phe Ala
                725                 730                 735     
Pro Leu Gln Pro Pro Ser Val Pro Ala Pro Ser Asp Tyr Pro Gly Gln
            740                 745                 750         
Gly Ser Ser Phe Leu Gly Pro Gly Thr Phe Pro Glu Ser Phe Pro Pro
        755                 760                 765             
Thr Thr Pro Ser Thr Pro Thr Leu Ala Glu Phe Thr Pro Gly Pro Pro
    770                 775                 780                 
Pro Ile Ser Tyr Gln Ser Asp Ile Pro Ser Ser Leu Leu Thr Ser Glu
785                 790                 795                 800 
Lys Ser Thr Ala Cys Leu Pro Ser Gln Met Ala Pro Ala Gly His Leu
                805                 810                 815     
Asp Pro Thr His Asn Pro Gly Thr Pro Gly Leu His Thr Ser Asn Leu
            820                 825                 830         
Gly Ala Pro Pro Gly Pro Gln Leu His His Ser Asn Pro Pro Pro Ala
        835                 840                 845             
Ser Arg Gln Ser Leu Gly Gln Ala Ser Leu Gly Pro Thr Gly Glu Leu
    850                 855                 860                 
Ala Phe Ser Pro Ala Thr Gly Val Met Gly Pro Pro Ser Met Ser Gly
865                 870                 875                 880 
Ala Gly Glu Ala Pro Glu Pro Ala Leu Asp Leu Leu Pro Glu Leu Thr
                885                 890                 895     
Asn Pro Asp Glu Leu Leu Ser Tyr Leu Gly Pro Pro Asp Leu Pro Thr
            900                 905                 910         
Asn Asn Asn Asp Asp Leu Leu Ser Leu Phe Glu Asn Asn
        915                 920                 925 


<210> 5846
<211> 655
<212> PRT
<213> Homo sapiens

<400> 5846
Leu Tyr Ala Gly Gln Arg Leu Pro Gln His Gly Tyr Pro Gly Pro Pro
 1               5                  10                  15      
Gln Ala Gln Pro Leu Pro Arg Gln Gly Val Lys Arg Thr Tyr Ser Glu
            20                  25                  30          
Val Tyr Pro Gly Gln Gln Tyr Leu Gln Gly Gly Gln Tyr Ala Pro Ser
        35                  40                  45              
Thr Ala Gln Phe Ala Pro Ser Pro Gly Gln Pro Pro Ala Pro Ser Pro
    50                  55                  60                  
Ser Tyr Pro Gly His Arg Leu Pro Leu Gln Gln Gly Met Thr Gln Ser
65                  70                  75                  80  
Leu Ser Val Pro Gly Pro Thr Gly Leu His Tyr Lys Pro Thr Arg Ser
                85                  90                  95      
Ile Pro Gly Tyr Pro Ser Ser Pro Leu Pro Gly Asn Pro Thr Pro Pro
            100                 105                 110         
Met Thr Pro Ser Ser Ser Val Pro Tyr Met Ser Pro Asn Gln Glu Val
        115                 120                 125             
Lys Ser Pro Phe Leu Pro Asp Leu Lys Pro Asn Leu Asn Ser Leu His
    130                 135                 140                 
Ser Ser Pro Ser Gly Ser Gly Pro Cys Asp Glu Leu Arg Leu Thr Phe
145                 150                 155                 160 
Pro Val Arg Asp Gly Val Val Leu Glu Pro Phe Arg Leu Gln His Asn
                165                 170                 175     
Leu Ala Val Ser Asn His Val Phe Gln Leu Arg Asp Ser Val Tyr Lys
            180                 185                 190         
Thr Leu Ile Met Arg Pro Asp Leu Glu Leu Gln Phe Lys Cys Tyr His
        195                 200                 205             
His Glu Asp Arg Gln Met Asn Thr Asn Trp Pro Ala Ser Val Gln Val
    210                 215                 220                 
Ser Val Asn Ala Thr Pro Leu Thr Ile Glu Arg Gly Asp Asn Lys Thr
225                 230                 235                 240 
Ser His Lys Pro Leu Tyr Leu Lys His Val Cys Gln Pro Gly Arg Asn
                245                 250                 255     
Thr Ile Gln Ile Thr Val Thr Ala Cys Cys Cys Ser His Leu Phe Val
            260                 265                 270         
Leu Gln Leu Val His Arg Pro Ser Val Arg Ser Val Leu Gln Gly Leu
        275                 280                 285             
Leu Lys Lys Arg Leu Leu Pro Ala Glu His Cys Ile Thr Lys Ile Lys
    290                 295                 300                 
Arg Asn Phe Ser Ser Gly Thr Ile Pro Gly Thr Pro Gly Pro Asn Gly
305                 310                 315                 320 
Glu Asp Gly Val Glu Gln Thr Ala Ile Lys Val Ser Leu Lys Cys Pro
                325                 330                 335     
Ile Thr Phe Arg Arg Ile Gln Leu Pro Ala Arg Gly His Asp Cys Arg
            340                 345                 350         
His Ile Gln Cys Phe Asp Leu Glu Ser Tyr Leu Gln Leu Asn Cys Glu
        355                 360                 365             
Arg Gly Thr Trp Arg Cys Pro Val Cys Asn Lys Thr Ala Leu Leu Glu
    370                 375                 380                 
Gly Leu Glu Val Asp Gln Tyr Met Leu Gly Ile Leu Ile Tyr Ile Gln
385                 390                 395                 400 
Asn Ser Asp Tyr Glu Glu Ile Thr Ile Asp Pro Thr Cys Ser Trp Lys
                405                 410                 415     
Pro Val Pro Val Lys Pro Asp Met His Ile Lys Glu Glu Pro Asp Gly
            420                 425                 430         
Pro Ala Leu Lys Arg Cys Arg Thr Val Ser Pro Ala His Val Leu Met
        435                 440                 445             
Pro Ser Val Met Glu Met Ile Ala Ala Leu Gly Pro Gly Ala Ala Pro
    450                 455                 460                 
Phe Ala Pro Leu Gln Pro Pro Ser Val Pro Ala Pro Ser Asp Tyr Pro
465                 470                 475                 480 
Gly Gln Gly Ser Ser Phe Leu Gly Pro Gly Thr Phe Pro Glu Ser Phe
                485                 490                 495     
Pro Pro Thr Met Pro Ser Thr Pro Thr Leu Ala Glu Phe Thr Pro Gly
            500                 505                 510         
Pro Pro Pro Ile Ser Tyr Gln Ser Asp Ile Pro Ser Ser Leu Leu Thr
        515                 520                 525             
Ser Glu Lys Ser Thr Ala Cys Leu Pro Ser Gln Met Ala Pro Ala Gly
    530                 535                 540                 
His Leu Asp Pro Thr His Asn Pro Gly Thr Pro Gly Leu His Thr Ser
545                 550                 555                 560 
Asn Leu Gly Ala Pro Pro Gly Pro Gln Leu His His Ser Asn Pro Pro
                565                 570                 575     
Pro Ala Ser Arg Gln Ser Leu Gly Gln Ala Ser Leu Gly Pro Thr Gly
            580                 585                 590         
Glu Leu Ala Phe Ser Pro Ala Thr Gly Val Met Gly Pro Pro Ser Met
        595                 600                 605             
Ser Gly Ala Gly Glu Ala Pro Glu Pro Ala Leu Asp Leu Leu Pro Glu
    610                 615                 620                 
Leu Thr Asn Pro Asp Glu Leu Leu Ser Tyr Leu Gly Pro Pro Asp Leu
625                 630                 635                 640 
Pro Thr Asn Asn Asn Asp Asp Leu Leu Ser Leu Phe Glu Asn Asn
                645                 650                 655 


<210> 5847
<211> 546
<212> PRT
<213> Homo sapiens

<400> 5847
Met Arg Pro Arg Thr Glu Gly Phe Phe Pro Pro Ala Gly Ala Ser Leu
 1               5                  10                  15      
Pro Phe Ser Thr Arg Asn Lys Gln Pro Ala Val Pro Ala Ala Ala Ala
            20                  25                  30          
Arg Ala Ala Glu His Ala Pro Gly Ala Gly Pro Gly Arg Asp Ser Gly
        35                  40                  45              
Ala Gly Thr Ala Pro Pro Ala Leu Arg Arg Arg Ala Ser Pro Cys Gly
    50                  55                  60                  
Leu Leu Pro Pro Phe Leu Pro Pro Gly Ser Ala Gly Gly Gly Gly Gly
65                  70                  75                  80  
Gly Ala Arg Arg Gly Pro Pro Ser Ala Ala Pro Pro Pro Arg Ala Gly
                85                  90                  95      
Ala Gly Gly Ala Gly Pro Ala Ser Ala Ser Arg Gly Gly Ser Ser Ala
            100                 105                 110         
Ala Arg Arg Arg Gly Gln Arg Ala Pro His Ser Asn Leu Pro Arg Lys
        115                 120                 125             
Asp Ser Leu Arg Pro Thr Met His Arg Gly Gly Gln Pro Leu Lys Lys
    130                 135                 140                 
Arg Arg Gly Ser Ser Lys Met Ala Glu Leu Asp Gln Leu Pro Asp Glu
145                 150                 155                 160 
Ser Ser Ser Ala Lys Ala Leu Val Ser Leu Lys Glu Gly Ser Leu Ser
                165                 170                 175     
Asn Thr Trp Asn Glu Lys Tyr Ser Ser Leu Gln Lys Thr Pro Val Trp
            180                 185                 190         
Lys Gly Arg Asn Thr Ser Ser Ala Val Glu Met Pro Phe Arg Asn Ser
        195                 200                 205             
Lys Arg Ser Arg Leu Phe Ser Asp Glu Asp Asp Arg Gln Ile Asn Thr
    210                 215                 220                 
Arg Ser Pro Lys Arg Asn Gln Arg Val Ala Met Val Pro Gln Lys Phe
225                 230                 235                 240 
Thr Ala Thr Met Ser Thr Pro Asp Lys Lys Ala Ser Gln Lys Ile Gly
                245                 250                 255     
Phe Arg Leu Arg Asn Leu Leu Lys Leu Pro Lys Ala His Lys Trp Cys
            260                 265                 270         
Ile Tyr Glu Trp Phe Tyr Ser Asn Ile Asp Lys Pro Leu Phe Glu Gly
        275                 280                 285             
Asp Asn Asp Phe Cys Val Cys Leu Lys Glu Ser Phe Pro Asn Leu Lys
    290                 295                 300                 
Thr Arg Lys Leu Thr Arg Val Glu Trp Gly Lys Ile Arg Arg Leu Met
305                 310                 315                 320 
Gly Lys Pro Arg Arg Cys Ser Ser Ala Phe Phe Glu Glu Glu Arg Ser
                325                 330                 335     
Ala Leu Lys Gln Lys Arg Gln Lys Ile Arg Leu Leu Gln Gln Arg Lys
            340                 345                 350         
Val Ala Asp Val Ser Gln Phe Lys Asp Leu Pro Asp Glu Ile Pro Leu
        355                 360                 365             
Pro Leu Val Ile Gly Thr Lys Val Thr Ala Arg Leu Arg Gly Val His
    370                 375                 380                 
Asp Gly Leu Phe Thr Gly Gln Ile Asp Ala Val Asp Thr Leu Asn Ala
385                 390                 395                 400 
Thr Tyr Arg Val Thr Phe Asp Arg Thr Gly Leu Gly Thr His Thr Ile
                405                 410                 415     
Pro Asp Tyr Glu Val Leu Ser Asn Glu Pro His Glu Thr Met Pro Ile
            420                 425                 430         
Ala Ala Leu Gly Gln Lys Gln Arg Pro Ser Arg Phe Phe Met Thr Pro
        435                 440                 445             
Pro Arg Leu His Tyr Thr Pro Pro Leu Gln Ser Pro Ile Ile Asp Asn
    450                 455                 460                 
Asp Pro Leu Leu Gly Gln Ser Pro Trp Arg Ser Lys Ile Ser Gly Ser
465                 470                 475                 480 
Asp Thr Glu Thr Leu Gly Gly Phe Pro Val Glu Phe Leu Ile Gln Val
                485                 490                 495     
Thr Arg Leu Ser Lys Ile Leu Met Ile His Gln Gly Thr Tyr Gln Glu
            500                 505                 510         
His Gln Gly His Glu His Arg Ser Arg Asn Thr Gly Asn His Ile Ala
        515                 520                 525             
Cys Gln Ser Ala Leu Asp Ser Arg Gly Asp Leu Arg Gln Ser Val Ser
    530                 535                 540                 
Gly Thr
545     


<210> 5848
<211> 692
<212> PRT
<213> Homo sapiens

<400> 5848
Met Arg Pro Arg Thr Glu Gly Phe Phe Pro Pro Ala Gly Ala Ser Leu
 1               5                  10                  15      
Pro Phe Ser Thr Arg Asn Lys Gln Pro Ala Val Pro Ala Ala Ala Ala
            20                  25                  30          
Arg Ala Ala Glu His Ala Pro Gly Ala Gly Pro Gly Arg Asp Ser Gly
        35                  40                  45              
Ala Gly Thr Ala Pro Pro Ala Leu Arg Arg Arg Ala Ser Pro Cys Gly
    50                  55                  60                  
Leu Leu Pro Pro Phe Leu Pro Pro Gly Ser Ala Gly Gly Gly Gly Gly
65                  70                  75                  80  
Gly Ala Arg Arg Gly Pro Pro Ser Ala Ala Pro Pro Pro Arg Ala Gly
                85                  90                  95      
Ala Gly Gly Ala Gly Pro Ala Ser Ala Ser Arg Gly Gly Ser Ser Ala
            100                 105                 110         
Ala Arg Arg Arg Gly Gln Arg Ala Pro His Ser Asn Leu Pro Arg Lys
        115                 120                 125             
Asp Ser Leu Arg Pro Thr Met His Arg Gly Gly Gln Pro Leu Lys Lys
    130                 135                 140                 
Arg Arg Gly Ser Phe Lys Met Ala Glu Leu Asp Gln Leu Pro Asp Glu
145                 150                 155                 160 
Ser Ser Ser Ala Lys Ala Leu Val Ser Leu Lys Glu Gly Ser Leu Ser
                165                 170                 175     
Asn Thr Trp Asn Glu Lys Tyr Ser Ser Leu Gln Lys Thr Pro Val Trp
            180                 185                 190         
Lys Gly Arg Asn Thr Ser Ser Ala Val Glu Met Pro Phe Arg Asn Ser
        195                 200                 205             
Lys Arg Ser Arg Leu Phe Ser Asp Glu Asp Asp Arg Gln Ile Asn Thr
    210                 215                 220                 
Arg Ser Pro Lys Arg Asn Gln Arg Val Ala Met Val Pro Gln Lys Phe
225                 230                 235                 240 
Thr Ala Thr Met Ser Thr Pro Asp Lys Lys Ala Ser Gln Lys Ile Gly
                245                 250                 255     
Phe Arg Leu Arg Asn Leu Leu Lys Leu Pro Lys Ala His Lys Trp Cys
            260                 265                 270         
Ile Tyr Glu Trp Phe Tyr Ser Asn Ile Asp Lys Pro Leu Phe Glu Gly
        275                 280                 285             
Asp Asn Asp Phe Cys Val Cys Leu Lys Glu Ser Phe Pro Asn Leu Lys
    290                 295                 300                 
Thr Arg Lys Leu Thr Arg Val Glu Trp Gly Lys Ile Arg Arg Leu Met
305                 310                 315                 320 
Gly Lys Pro Arg Arg Cys Ser Ser Ala Phe Phe Glu Glu Glu Arg Ser
                325                 330                 335     
Ala Leu Lys Gln Lys Arg Gln Lys Ile Arg Leu Leu Gln Gln Arg Lys
            340                 345                 350         
Val Ala Asp Val Ser Gln Phe Lys Asp Leu Pro Asp Glu Ile Pro Leu
        355                 360                 365             
Pro Leu Val Ile Gly Thr Lys Val Thr Ala Arg Leu Arg Gly Val His
    370                 375                 380                 
Asp Gly Leu Phe Thr Gly Gln Ile Asp Ala Val Asp Thr Leu Asn Ala
385                 390                 395                 400 
Thr Tyr Arg Val Thr Phe Asp Arg Thr Gly Leu Gly Thr His Thr Ile
                405                 410                 415     
Pro Asp Tyr Glu Val Leu Ser Asn Glu Pro His Glu Thr Met Pro Ile
            420                 425                 430         
Ala Ala Phe Gly Gln Lys Gln Arg Pro Ser Arg Phe Phe Met Thr Pro
        435                 440                 445             
Pro Arg Leu His Tyr Thr Pro Pro Leu Gln Ser Pro Ile Ile Asp Asn
    450                 455                 460                 
Asp Pro Leu Leu Gly Gln Ser Pro Trp Arg Ser Lys Ile Ser Gly Ser
465                 470                 475                 480 
Asp Thr Glu Thr Leu Gly Gly Phe Pro Val Glu Phe Leu Ile Gln Val
                485                 490                 495     
Thr Arg Leu Ser Lys Ile Leu Met Ile Lys Lys Glu His Ile Lys Lys
            500                 505                 510         
Leu Arg Glu Met Asn Thr Glu Ala Glu Lys Leu Lys Ser Tyr Ser Met
        515                 520                 525             
Pro Ile Ser Ile Glu Phe Gln Arg Arg Tyr Ala Thr Ile Val Leu Glu
    530                 535                 540                 
Leu Glu Gln Leu Asn Lys Asp Leu Asn Lys Val Leu His Lys Val Gln
545                 550                 555                 560 
Gln Tyr Cys Tyr Glu Leu Ala Pro Asp Gln Gly Leu Gln Pro Ala Asp
                565                 570                 575     
Gln Pro Thr Asp Met Arg Arg Arg Cys Glu Glu Glu Ala Gln Glu Ile
            580                 585                 590         
Val Arg His Ala Asn Ser Ser Thr Gly Gln Pro Cys Val Glu Asn Glu
        595                 600                 605             
Asn Leu Thr Asp Leu Ile Ser Arg Leu Thr Ala Ile Leu Leu Gln Ile
    610                 615                 620                 
Lys Cys Leu Ala Glu Gly Gly Asp Leu Asn Ser Phe Glu Phe Lys Ser
625                 630                 635                 640 
Leu Thr Asp Ser Leu Asn Asp Ile Lys Ser Thr Ile Asp Ala Ser Asn
                645                 650                 655     
Ile Ser Cys Phe Gln Asn Asn Val Glu Ile His Val Ala His Ile Gln
            660                 665                 670         
Ser Gly Leu Ser Gln Met Gly Asn Leu His Ala Phe Ala Ala Asn Asn
        675                 680                 685             
Thr Asn Arg Asp
    690         


<210> 5849
<211> 198
<212> PRT
<213> Homo sapiens

<400> 5849
Met Pro Ser Ser Thr Leu Pro Gly Trp Pro Gly Ser Ser Gly Gly Pro
 1               5                  10                  15      
Val Ser Arg Pro Ser Ser Leu Glu Ser Ser Arg Asn Thr Ser Ser Asn
            20                  25                  30          
Ser Ser Pro Leu Asn Leu Lys Gly Ser Ser Glu Gln Leu His Gly Arg
        35                  40                  45              
Ser Glu Ser Phe Ser Ser Glu Asp Leu Ile Pro Ser Arg Asp Leu Ala
    50                  55                  60                  
Thr Leu Pro Arg Glu Ala Ser Thr Pro Gly Arg Asn Ala Leu Gly Arg
65                  70                  75                  80  
His Glu Tyr Pro Leu Pro Arg Asn Gly Pro Leu Pro Gln Glu Gly Ala
                85                  90                  95      
Gln Lys Arg Gly Thr Ala Pro Pro Tyr Val Gly Val Arg Pro Cys Ser
            100                 105                 110         
Ala Ser Pro Ser Ser Glu Met Val Thr Leu Glu Glu Phe Leu Glu Glu
        115                 120                 125             
Ser Asn Arg Ser Ser Pro Thr His Asp Thr Pro Ser Cys Arg Asp Asp
    130                 135                 140                 
Leu Leu Ser Asp Tyr Phe Arg Lys Ala Ser Asp Pro Pro Ala Ile Gly
145                 150                 155                 160 
Gly Gln Pro Gly Pro Pro Ala Lys Lys Glu Gly Ala Lys Met Pro Thr
                165                 170                 175     
Asn Phe Val Ala Pro Thr Val Lys Met Ala Ala Pro Thr Ser Glu Gly
            180                 185                 190         
Arg Pro Leu Lys Pro Gly
        195             


<210> 5850
<211> 731
<212> PRT
<213> Homo sapiens

<400> 5850
Met Ser Leu Phe Leu Ser Asn Leu Ser Thr Asn Asp Ser Ser Leu Trp
 1               5                  10                  15      
Lys Glu Asn His Asn Ser Thr Asp Leu Leu Asn Pro Pro Gly Thr Leu
            20                  25                  30          
Asn Ile Tyr Leu Phe Cys Leu Thr Cys Leu Met Thr Phe Ala Ala Leu
        35                  40                  45              
Val Gly Ser Ile Tyr Ser Leu Ile Ser Leu Leu Lys Met Gln Asn Arg
    50                  55                  60                  
Thr Val Val Ser Met Leu Val Ala Ser Trp Ser Val Asp Asp Leu Met
65                  70                  75                  80  
Ser Val Leu Ser Val Thr Ile Phe Met Phe Leu Gln Trp Pro Asn Glu
                85                  90                  95      
Val Pro Gly Tyr Phe Gln Phe Leu Cys Thr Thr Ser Ala Leu Met Tyr
            100                 105                 110         
Leu Cys Gln Gly Leu Ser Ser Asn Leu Lys Ala Thr Leu Leu Val Ser
        115                 120                 125             
Tyr Asn Phe Tyr Thr Met His Arg Gly Val Gly Ser Gln Thr Ala Ser
    130                 135                 140                 
Arg Arg Ser Gly Gln Val Leu Gly Val Val Leu Thr Val Trp Ala Ala
145                 150                 155                 160 
Ser Leu Leu Leu Ser Ala Leu Pro Leu Cys Gly Trp Gly Ala Phe Val
                165                 170                 175     
Arg Thr Pro Trp Gly Cys Leu Val Asp Cys Ser Ser Ser Tyr Val Leu
            180                 185                 190         
Phe Leu Ser Ile Val Tyr Ala Leu Ala Phe Gly Leu Leu Val Gly Leu
        195                 200                 205             
Ser Val Pro Leu Thr His Arg Leu Leu Cys Ser Glu Glu Pro Pro Arg
    210                 215                 220                 
Leu His Ser Asn Tyr Gln Glu Ile Ser Arg Gly Ala Ser Ile Pro Gly
225                 230                 235                 240 
Thr Pro Pro Thr Ala Gly Arg Val Val Ser Leu Ser Pro Glu Asp Ala
                245                 250                 255     
Pro Gly Pro Ser Leu Arg Arg Ser Gly Gly Cys Ser Pro Ser Ser Asp
            260                 265                 270         
Thr Val Phe Gly Pro Gly Ala Pro Ala Ala Ala Gly Ala Glu Ala Cys
        275                 280                 285             
Arg Arg Glu Asn Arg Gly Thr Leu Tyr Gly Thr Arg Ser Phe Thr Val
    290                 295                 300                 
Ser Val Ala Gln Lys Arg Phe Ala Leu Ile Leu Ala Leu Thr Lys Val
305                 310                 315                 320 
Val Leu Trp Leu Pro Met Met Met His Met Val Val Gln Asn Val Val
                325                 330                 335     
Gly Phe Gln Ser Leu Pro Leu Glu Thr Phe Ser Phe Leu Leu Thr Leu
            340                 345                 350         
Leu Ala Thr Thr Val Thr Pro Val Phe Val Leu Ser Lys Arg Trp Thr
        355                 360                 365             
His Leu Pro Cys Gly Cys Ile Ile Asn Cys Arg Gln Asn Ala Tyr Ala
    370                 375                 380                 
Val Ala Ser Asp Gly Lys Lys Ile Lys Arg Lys Gly Phe Glu Phe Asn
385                 390                 395                 400 
Leu Ser Phe Gln Lys Ser Tyr Gly Ile Tyr Lys Ile Ala His Glu Asp
                405                 410                 415     
Tyr Tyr Asp Asp Asp Glu Asn Ser Ile Phe Tyr His Asn Leu Met Asn
            420                 425                 430         
Ser Glu Cys Glu Thr Thr Lys Asp Pro Gln Arg Asp Asn Arg Asn Ile
        435                 440                 445             
Phe Asn Ala Ile Lys Val Glu Ile Ser Thr Thr Pro Ser Leu Asp Ser
    450                 455                 460                 
Ser Thr Gln Arg Gly Ile Asn Lys Cys Thr Asn Thr Asp Ile Thr Glu
465                 470                 475                 480 
Ala Lys Gln Asp Ser Asn Asn Lys Lys Asp Ala Phe Ser Asp Lys Thr
                485                 490                 495     
Gly Gly Asp Ile Asn Tyr Glu Glu Thr Thr Phe Ser Glu Gly Pro Glu
            500                 505                 510         
Arg Arg Leu Ser His Glu Glu Ser Gln Lys Pro Asp Leu Ser Asp Trp
        515                 520                 525             
Glu Trp Cys Arg Ser Lys Ser Glu Arg Thr Pro Arg Gln Arg Ser Gly
    530                 535                 540                 
Tyr Ala Leu Ala Ile Pro Leu Cys Ala Phe Gln Gly Thr Val Ser Leu
545                 550                 555                 560 
His Ala Pro Thr Gly Lys Thr Leu Ser Leu Ser Thr Tyr Glu Val Ser
                565                 570                 575     
Ala Glu Gly Gln Lys Ile Thr Pro Ala Ser Lys Lys Ile Glu Val Tyr
            580                 585                 590         
Arg Ser Lys Ser Val Gly His Glu Pro Asn Ser Glu Asp Ser Ser Ser
        595                 600                 605             
Thr Phe Val Asp Thr Ser Val Lys Ile His Leu Glu Val Leu Glu Ile
    610                 615                 620                 
Cys Asp Asn Glu Glu Ala Leu Asp Thr Val Ser Ile Ile Ser Asn Ile
625                 630                 635                 640 
Ser Gln Ser Ser Thr Gln Val Arg Ser Pro Ser Leu Arg Tyr Ser Arg
                645                 650                 655     
Lys Glu Asn Arg Phe Val Ser Cys Asp Leu Gly Glu Thr Ala Ser Tyr
            660                 665                 670         
Ser Leu Phe Leu Pro Thr Ser Asn Pro Asp Gly Asp Ile Asn Ile Ser
        675                 680                 685             
Ile Pro Asp Thr Val Glu Ala His Arg Gln Asn Ser Lys Arg Gln His
    690                 695                 700                 
Gln Glu Arg Asp Gly Tyr Gln Glu Glu Ile Gln Leu Leu Asn Lys Ala
705                 710                 715                 720 
Tyr Arg Lys Arg Glu Glu Glu Ser Lys Gly Ser
                725                 730     


<210> 5851
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5851
Met Leu Pro Phe Leu Leu Ala Thr Leu Gly Thr Thr Ala Leu Asn Asn
 1               5                  10                  15      
Ser Asn Pro Lys Asp Tyr Cys Tyr Ser Ala Arg Ile Arg Ser Thr Val
            20                  25                  30          
Leu Gln Gly Leu Pro Phe Gly Gly Val Pro Thr Val Leu Ala Leu Asp
        35                  40                  45              
Phe Met Cys Phe Leu Ala Leu Leu Phe Leu Phe Ser Ile Leu Arg Lys
    50                  55                  60                  
Val Ala Trp Asp Tyr Gly Arg Leu Ala Leu Val Thr Asp Ala Asp Arg
65                  70                  75                  80  
Leu Arg Arg Gln Glu Arg Asp Arg Val Glu Gln Glu Tyr Val Ala Ser
                85                  90                  95      
Ala Met His Gly Asp Ser His Asp Arg Tyr Glu Arg Leu Thr Ser Val
            100                 105                 110         
Ser Ser Ser Val Asp Phe Asp Gln Arg Asp Asn Gly Phe Cys Ser Trp
        115                 120                 125             
Leu Thr Ala Ile Phe Arg Ile Lys Asp Asp Glu Ile Arg Asp Lys Cys
    130                 135                 140                 
Gly Gly Asp Ala Val His Tyr Leu Ser Phe Gln Arg His Ile Ile Gly
145                 150                 155                 160 
Leu Leu Val Val Val Gly Val Leu Ser Val Gly Ile Val Leu Pro Val
                165                 170                 175     
Asn Phe Ser Gly Asp Leu Leu Glu Asn Asn Ala Tyr Ser Phe Gly Arg
            180                 185                 190         
Thr Thr Ile Ala Asn Leu Lys Ser Gly Asn Asn Leu Leu Trp Leu His
        195                 200                 205             
Thr Ser Phe Ala Phe Leu Tyr Leu Leu Leu Thr Val Tyr Ser Met Arg
    210                 215                 220                 
Arg His Thr Ser Lys Met Arg Tyr Lys Glu Asp Asp Leu Val Lys Arg
225                 230                 235                 240 
Thr Leu Phe Ile Asn Gly Ile Ser Lys Tyr Ala Glu Ser Glu Lys Ile
                245                 250                 255     
Lys Lys His Phe Glu Glu Ala Tyr Pro Asn Cys Thr Val Leu Glu Ala
            260                 265                 270         
Arg Pro Cys Tyr Asn Val Ala Arg Leu Met Phe Leu Asp Ala Glu Arg
        275                 280                 285             
Lys Lys Ala Glu Arg Gly Lys Leu Tyr Leu Thr Asn Leu Gln Ser Lys
    290                 295                 300                 
Glu Asn Val Pro Thr Met Ile Asn Pro Lys Pro Cys Gly His Leu Cys
305                 310                 315                 320 
Cys Cys Val Val Arg Gly Cys Glu Gln Val Glu Ala Ile Glu Tyr Tyr
                325                 330                 335     
Thr Lys Leu Glu Gln Lys Leu Lys Glu Asp Tyr Lys Arg Glu Lys Glu
            340                 345                 350         
Lys Val Asn Glu Lys Pro Leu Gly Met Ala Phe Val Thr Phe His Asn
        355                 360                 365             
Glu Thr Ile Thr Ala Ile Ile Leu Lys Asp Phe Asn Val Cys Lys Cys
    370                 375                 380                 
Gln Gly Cys Thr Cys Arg Gly Glu Pro Arg Pro Ser Ser Cys Ser Glu
385                 390                 395                 400 
Ser Leu His Ile Ser Asn Trp Thr Val Ser Tyr Ala Pro Asp Pro Gln
                405                 410                 415     
Asn Ile Tyr Trp Glu His Leu Ser Ile Arg Gly Phe Ile Trp Trp Leu
            420                 425                 430         
Arg Cys Leu Val Ile Asn Val Val Leu Phe Ile Leu Leu Phe Phe Leu
        435                 440                 445             
Thr Thr Pro Ala Ile Ile Ile Thr Thr Met Asp Lys Phe Asn Val Thr
    450                 455                 460                 
Lys Pro Val Glu Tyr Leu Asn Val Arg Pro His Ala Pro Val Thr Phe
465                 470                 475                 480 
His Ala Gly Ser Gln His Thr Asp Thr Arg Pro
                485                 490     


<210> 5852
<211> 819
<212> PRT
<213> Homo sapiens

<400> 5852
Met Leu Pro Phe Leu Leu Ala Thr Leu Gly Thr Thr Ala Leu Asn Asn
 1               5                  10                  15      
Ser Asn Pro Lys Asp Tyr Cys Tyr Ser Ala Arg Ile Arg Ser Thr Val
            20                  25                  30          
Leu Gln Gly Leu Pro Phe Gly Gly Val Pro Thr Val Leu Ala Leu Asp
        35                  40                  45              
Phe Met Cys Phe Leu Ala Leu Leu Phe Leu Phe Ser Ile Leu Arg Lys
    50                  55                  60                  
Val Ala Trp Asp Tyr Gly Arg Leu Ala Leu Val Thr Asp Ala Asp Ser
65                  70                  75                  80  
Val Ala Ser Ala Met His Gly Asp Ser His Asp Arg Tyr Glu Arg Leu
                85                  90                  95      
Thr Ser Val Ser Ser Ser Val Asp Phe Asp Gln Arg Asp Asn Gly Phe
            100                 105                 110         
Cys Ser Trp Leu Thr Ala Ile Phe Arg Ile Lys Asp Asp Glu Ile Arg
        115                 120                 125             
Asp Lys Cys Gly Gly Asp Ala Val His Tyr Leu Ser Phe Gln Arg His
    130                 135                 140                 
Ile Ile Gly Leu Leu Val Val Val Gly Val Leu Ser Val Gly Ile Val
145                 150                 155                 160 
Leu Pro Val Asn Phe Ser Gly Asp Leu Leu Glu Asn Asn Ala Tyr Ser
                165                 170                 175     
Phe Gly Arg Thr Thr Ile Ala Asn Leu Lys Ser Gly Asn Asn Leu Leu
            180                 185                 190         
Trp Leu His Thr Ser Phe Ala Phe Leu Tyr Leu Leu Leu Thr Val Tyr
        195                 200                 205             
Ser Met Arg Arg His Thr Ser Lys Met Arg Tyr Lys Glu Asp Asp Leu
    210                 215                 220                 
Val Lys Arg Thr Leu Phe Ile Asn Gly Ile Ser Lys Tyr Ala Glu Ser
225                 230                 235                 240 
Glu Lys Ile Lys Lys His Phe Glu Glu Ala Tyr Pro Asn Cys Thr Val
                245                 250                 255     
Leu Glu Ala Arg Pro Cys Tyr Asn Val Ala Arg Leu Met Phe Leu Asp
            260                 265                 270         
Ala Glu Arg Lys Lys Ala Glu Arg Gly Lys Leu Tyr Phe Thr Asn Leu
        275                 280                 285             
Gln Ser Lys Glu Asn Val Pro Thr Met Ile Asn Pro Lys Pro Cys Gly
    290                 295                 300                 
His Leu Cys Cys Cys Val Val Arg Gly Cys Glu Gln Val Glu Ala Ile
305                 310                 315                 320 
Glu Tyr Tyr Thr Lys Leu Glu Gln Lys Leu Lys Glu Asp Tyr Lys Arg
                325                 330                 335     
Glu Lys Glu Lys Val Asn Glu Lys Pro Leu Gly Met Ala Phe Val Thr
            340                 345                 350         
Phe His Asn Glu Thr Ile Thr Ala Ile Ile Leu Lys Asp Phe Asn Val
        355                 360                 365             
Cys Lys Cys Gln Gly Cys Thr Cys Arg Gly Glu Pro Arg Pro Ser Ser
    370                 375                 380                 
Cys Ser Glu Ser Leu His Ile Ser Asn Trp Thr Val Ser Tyr Ala Pro
385                 390                 395                 400 
Asp Pro Gln Asn Ile Tyr Trp Glu His Leu Ser Ile Arg Gly Phe Ile
                405                 410                 415     
Trp Trp Leu Arg Cys Leu Val Ile Asn Val Val Leu Phe Ile Leu Leu
            420                 425                 430         
Phe Phe Leu Thr Thr Pro Ala Ile Ile Ile Thr Thr Met Asp Lys Phe
        435                 440                 445             
Asn Val Thr Lys Pro Val Glu Tyr Leu Asn Asn Pro Ile Ile Thr Gln
    450                 455                 460                 
Phe Phe Pro Thr Leu Leu Leu Trp Cys Phe Ser Ala Leu Leu Pro Thr
465                 470                 475                 480 
Ile Val Tyr Tyr Ser Ala Phe Phe Glu Ala His Trp Thr Arg Ser Gly
                485                 490                 495     
Glu Asn Arg Thr Thr Met His Lys Cys Tyr Thr Phe Leu Ile Phe Met
            500                 505                 510         
Val Leu Leu Leu Pro Ser Leu Gly Leu Ser Ser Leu Asp Leu Phe Phe
        515                 520                 525             
Arg Trp Leu Phe Asp Lys Lys Phe Leu Ala Glu Ala Ala Ile Arg Phe
    530                 535                 540                 
Glu Cys Val Phe Leu Pro Asp Asn Gly Ala Phe Phe Val Asn Tyr Val
545                 550                 555                 560 
Ile Ala Ser Ala Phe Ile Gly Asn Ala Met Asp Leu Leu Arg Ile Pro
                565                 570                 575     
Gly Leu Leu Met Tyr Met Ile Arg Leu Cys Leu Ala Arg Ser Ala Ala
            580                 585                 590         
Glu Arg Arg Asn Val Lys Arg His Gln Ala Tyr Glu Phe Gln Phe Gly
        595                 600                 605             
Ala Ala Tyr Ala Trp Met Met Cys Val Phe Thr Val Val Met Thr Tyr
    610                 615                 620                 
Ser Ile Thr Cys Pro Ile Ile Val Pro Phe Gly Leu Met Tyr Met Leu
625                 630                 635                 640 
Leu Lys His Leu Val Asp Arg Tyr Asn Leu Tyr Tyr Ala Tyr Leu Pro
                645                 650                 655     
Ala Lys Leu Asp Lys Lys Ile His Ser Gly Ala Val Asn Gln Val Val
            660                 665                 670         
Ala Ala Pro Ile Leu Cys Leu Phe Trp Leu Leu Phe Phe Ser Thr Met
        675                 680                 685             
Arg Thr Gly Phe Leu Ala Pro Thr Ser Met Phe Thr Phe Val Val Leu
    690                 695                 700                 
Val Ile Thr Ile Val Ile Cys Leu Cys His Val Cys Phe Gly His Phe
705                 710                 715                 720 
Lys Tyr Leu Ser Ala His Asn Tyr Lys Ile Glu His Thr Glu Thr Asp
                725                 730                 735     
Thr Val Asp Pro Arg Ser Asn Gly Arg Pro Pro Thr Ala Ala Ala Val
            740                 745                 750         
Pro Lys Ser Ala Lys Tyr Ile Ala Gln Val Leu Gln Asp Ser Glu Val
        755                 760                 765             
Asp Gly Asp Gly Asp Gly Ala Pro Gly Ser Ser Gly Asp Glu Pro Pro
    770                 775                 780                 
Ser Ser Ser Ser Gln Asp Glu Glu Leu Leu Met Pro Pro Asp Ala Leu
785                 790                 795                 800 
Thr Asp Thr Asp Phe Gln Ser Cys Glu Asp Ser Leu Ile Glu Asn Glu
                805                 810                 815     
Ile His Gln
            


<210> 5853
<211> 151
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 12, 77, 78, 79, 80, 81, 132, 145, 146, 147
<223> Xaa = Any Amino Acid

<400> 5853
Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys Xaa Asp Gly Gln Ser
 1               5                  10                  15      
Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr Pro Glu Arg Val Glu
            20                  25                  30          
Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly Lys Asn Leu Thr Leu
        35                  40                  45              
Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val
    50                  55                  60                  
Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu Pro Xaa Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Ala Glu Val Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly
                85                  90                  95      
Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu
            100                 105                 110         
Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln Leu Gln Thr Phe Val
        115                 120                 125             
Leu Pro Ala Xaa Pro Pro Gln Leu Val Ser Pro Arg Val Leu Glu Val
    130                 135                 140                 
Xaa Xaa Xaa Gly Thr Val Val
145                 150     


<210> 5854
<211> 1007
<212> PRT
<213> Homo sapiens

<400> 5854
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro
 1               5                  10                  15      
Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly
            20                  25                  30          
Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg
        35                  40                  45              
Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu
    50                  55                  60                  
Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro
65                  70                  75                  80  
Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val
                85                  90                  95      
Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp
            100                 105                 110         
Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys
        115                 120                 125             
Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro
    130                 135                 140                 
Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile
145                 150                 155                 160 
His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly
                165                 170                 175     
Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu
            180                 185                 190         
Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro
        195                 200                 205             
Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly
    210                 215                 220                 
Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe
225                 230                 235                 240 
Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys
                245                 250                 255     
Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu
            260                 265                 270         
Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile
        275                 280                 285             
Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr
    290                 295                 300                 
Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu
305                 310                 315                 320 
Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser
                325                 330                 335     
Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro
            340                 345                 350         
His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg
        355                 360                 365             
Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr
    370                 375                 380                 
Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu
385                 390                 395                 400 
Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile
                405                 410                 415     
Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly
            420                 425                 430         
Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu
        435                 440                 445             
Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro
    450                 455                 460                 
Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr
465                 470                 475                 480 
Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly
                485                 490                 495     
Glu Gly Asn His Leu Pro Thr Thr Pro Cys Tyr Leu Gln Trp Gly Thr
            500                 505                 510         
His Arg Glu Phe Leu Arg Arg Phe Ser Ile Trp Asn His Gly His Leu
        515                 520                 525             
His Met Asn Pro Gly Pro Glu Arg Gly Val Glu Phe Ser Leu Ile Gly
    530                 535                 540                 
Glu Ser Thr Ile Arg Cys Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp
545                 550                 555                 560 
Ser Gly Pro Ala Pro Leu Cys Lys Leu Ser Leu Leu Ala Val Gln Cys
                565                 570                 575     
Ser His Val His Ile Ala Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala
            580                 585                 590         
Pro Tyr Phe Tyr Asn Asp Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe
        595                 600                 605             
Thr Leu Lys Gly Ser Ser Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp
    610                 615                 620                 
Asp Pro Glu Ile Pro Val Cys Glu Lys Glu Thr Cys Gln His Val Arg
625                 630                 635                 640 
Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg Val Glu Leu Val Asn
                645                 650                 655     
Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly His Ala Tyr Gln Met
            660                 665                 670         
Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys
        675                 680                 685             
Lys Val Ile His Cys His Pro Pro Pro Val Ile Val Asn Gly Lys His
    690                 695                 700                 
Thr Gly Met Met Ala Glu Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr
705                 710                 715                 720 
Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys
                725                 730                 735     
Arg Ser Asp Ser Lys Gly His Gly Ser Trp Ser Gly Pro Ser Pro Gln
            740                 745                 750         
Cys Leu Arg Ser Pro Pro Val Thr Arg Cys Pro Asn Pro Glu Val Lys
        755                 760                 765             
His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala Tyr Ser His Asn Asp
    770                 775                 780                 
Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile Met Asn Gly Ser Arg
785                 790                 795                 800 
Val Ile Arg Cys His Thr Asp Asn Thr Trp Val Pro Gly Val Pro Thr
                805                 810                 815     
Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro
            820                 825                 830         
Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg Phe Ser Pro Gly Met
        835                 840                 845             
Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu Leu Val Gly Glu Ala
    850                 855                 860                 
Leu Leu Leu Cys Thr His Glu Gly Thr Trp Ser Gln Pro Ala Pro His
865                 870                 875                 880 
Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp Met Asp Gly Ile Gln
                885                 890                 895     
Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr Gly Ala Val Val Thr
            900                 905                 910         
Leu Glu Cys Glu Asp Gly Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln
        915                 920                 925             
Cys Gln Ser Asp His Gln Trp Asn Pro Pro Leu Ala Val Cys Arg Ser
    930                 935                 940                 
Arg Ser Leu Ala Pro Val Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu
945                 950                 955                 960 
Leu Thr Phe Leu Ile Val Ile Thr Leu Tyr Val Ile Ser Lys His Arg
                965                 970                 975     
Glu Arg Asn Tyr Tyr Thr Asp Thr Ser Gln Lys Glu Ala Phe His Leu
            980                 985                 990         
Glu Ala Arg Glu Val Tyr Ser Val Asp Pro Tyr Asn Pro Ala Ser
        995                 1000                1005        


<210> 5855
<211> 1033
<212> PRT
<213> Homo sapiens

<400> 5855
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro
 1               5                  10                  15      
Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly
            20                  25                  30          
Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg
        35                  40                  45              
Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu
    50                  55                  60                  
Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro
65                  70                  75                  80  
Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val
                85                  90                  95      
Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp
            100                 105                 110         
Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys
        115                 120                 125             
Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro
    130                 135                 140                 
Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile
145                 150                 155                 160 
His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly
                165                 170                 175     
Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu
            180                 185                 190         
Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro
        195                 200                 205             
Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly
    210                 215                 220                 
Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe
225                 230                 235                 240 
Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys
                245                 250                 255     
Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu
            260                 265                 270         
Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile
        275                 280                 285             
Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr
    290                 295                 300                 
Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu
305                 310                 315                 320 
Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser
                325                 330                 335     
Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro
            340                 345                 350         
His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg
        355                 360                 365             
Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr
    370                 375                 380                 
Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu
385                 390                 395                 400 
Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile
                405                 410                 415     
Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly
            420                 425                 430         
Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu
        435                 440                 445             
Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro
    450                 455                 460                 
Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr
465                 470                 475                 480 
Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly
                485                 490                 495     
Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr
            500                 505                 510         
Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro
        515                 520                 525             
Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu
    530                 535                 540                 
Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro
545                 550                 555                 560 
Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys
                565                 570                 575     
Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu
            580                 585                 590         
Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala
        595                 600                 605             
Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp
    610                 615                 620                 
Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser
625                 630                 635                 640 
Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val
                645                 650                 655     
Cys Glu Lys Glu Thr Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu
            660                 665                 670         
Pro Ala Gly Ser Arg Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly
        675                 680                 685             
Tyr Gln Leu Thr Gly His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn
    690                 695                 700                 
Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys Lys Val Ile His Cys His
705                 710                 715                 720 
Pro Pro Pro Val Ile Val Asn Gly Lys His Thr Gly Met Met Ala Glu
                725                 730                 735     
Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe
            740                 745                 750         
Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly
        755                 760                 765             
His Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro
    770                 775                 780                 
Val Thr Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn
785                 790                 795                 800 
Lys Thr His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys
                805                 810                 815     
Asn Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg Cys His Thr
            820                 825                 830         
Asp Asn Thr Trp Val Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe
        835                 840                 845             
Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly
    850                 855                 860                 
Gly Asn Ile Ala Arg Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys
865                 870                 875                 880 
Asp Gln Gly Tyr Leu Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His
                885                 890                 895     
Glu Gly Thr Trp Ser Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys
            900                 905                 910         
Ser Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg
        915                 920                 925             
Lys Met Tyr Gln Tyr Gly Ala Val Val Thr Leu Glu Cys Glu Asp Gly
    930                 935                 940                 
Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser Asp His Gln
945                 950                 955                 960 
Trp Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu Ala Pro Val
                965                 970                 975     
Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Thr Phe Leu Ile Val
            980                 985                 990         
Ile Thr Leu Tyr Val Ile Ser Lys His Arg Glu Arg Asn Tyr Tyr Thr
        995                 1000                1005            
Asp Thr Ser Gln Lys Glu Ala Phe His Leu Glu Ala Arg Glu Val Tyr
    1010                1015                1020                
Ser Val Asp Pro Tyr Asn Pro Ala Ser
1025                1030            


<210> 5856
<211> 1092
<212> PRT
<213> Homo sapiens

<400> 5856
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro
 1               5                  10                  15      
Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly
            20                  25                  30          
Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg
        35                  40                  45              
Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu
    50                  55                  60                  
Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro
65                  70                  75                  80  
Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val
                85                  90                  95      
Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp
            100                 105                 110         
Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys
        115                 120                 125             
Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro
    130                 135                 140                 
Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile
145                 150                 155                 160 
His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly
                165                 170                 175     
Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu
            180                 185                 190         
Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro
        195                 200                 205             
Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly
    210                 215                 220                 
Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe
225                 230                 235                 240 
Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys
                245                 250                 255     
Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu
            260                 265                 270         
Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile
        275                 280                 285             
Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr
    290                 295                 300                 
Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu
305                 310                 315                 320 
Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser
                325                 330                 335     
Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro
            340                 345                 350         
His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg
        355                 360                 365             
Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr
    370                 375                 380                 
Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu
385                 390                 395                 400 
Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile
                405                 410                 415     
Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly
            420                 425                 430         
Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu
        435                 440                 445             
Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro
    450                 455                 460                 
Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr
465                 470                 475                 480 
Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly
                485                 490                 495     
Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr
            500                 505                 510         
Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro
        515                 520                 525             
Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu
    530                 535                 540                 
Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro
545                 550                 555                 560 
Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys
                565                 570                 575     
Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu
            580                 585                 590         
Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala
        595                 600                 605             
Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp
    610                 615                 620                 
Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser
625                 630                 635                 640 
Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val
                645                 650                 655     
Cys Glu Lys Gly Cys Gln Pro Pro Pro Gly Leu His His Gly Arg His
            660                 665                 670         
Thr Gly Gly Asn Thr Val Phe Phe Val Ser Gly Met Thr Val Asp Tyr
        675                 680                 685             
Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys
    690                 695                 700                 
Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Thr
705                 710                 715                 720 
Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg
                725                 730                 735     
Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly
            740                 745                 750         
His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys
        755                 760                 765             
Lys Ile Pro Leu Cys Lys Val Ile His Cys His Pro Pro Pro Val Ile
    770                 775                 780                 
Val Asn Gly Lys His Thr Gly Met Met Ala Glu Asn Phe Leu Tyr Gly
785                 790                 795                 800 
Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu
                805                 810                 815     
Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly His Gly Ser Trp Ser
            820                 825                 830         
Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro Val Thr Arg Cys Pro
        835                 840                 845             
Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala
    850                 855                 860                 
Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile
865                 870                 875                 880 
Met Asn Gly Ser Arg Val Ile Arg Cys His Thr Asp Asn Thr Trp Val
                885                 890                 895     
Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro
            900                 905                 910         
Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg
        915                 920                 925             
Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu
    930                 935                 940                 
Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His Glu Gly Thr Trp Ser
945                 950                 955                 960 
Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp
                965                 970                 975     
Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr
            980                 985                 990         
Gly Ala Val Val Thr Leu Glu Cys Glu Asp Gly Tyr Met Leu Glu Gly
        995                 1000                1005            
Ser Pro Gln Ser Gln Cys Gln Ser Asp His Gln Trp Asn Pro Pro Leu
    1010                1015                1020                
Ala Val Cys Arg Ser Arg Ser Leu Ala Pro Val Leu Cys Gly Ile Ala
1025                1030                1035                1040
Ala Gly Leu Ile Leu Leu Thr Phe Leu Ile Val Ile Thr Leu Tyr Val
                1045                1050                1055    
Ile Ser Lys His Arg Glu Arg Asn Tyr Tyr Thr Asp Thr Ser Gln Lys
            1060                1065                1070        
Glu Ala Phe His Leu Glu Ala Arg Glu Val Tyr Ser Val Asp Pro Tyr
        1075                1080                1085            
Asn Pro Ala Ser
    1090        


<210> 5857
<211> 1084
<212> PRT
<213> Homo sapiens

<400> 5857
Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro
 1               5                  10                  15      
Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly
            20                  25                  30          
Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg
        35                  40                  45              
Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu
    50                  55                  60                  
Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro
65                  70                  75                  80  
Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val
                85                  90                  95      
Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp
            100                 105                 110         
Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys
        115                 120                 125             
Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro
    130                 135                 140                 
Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile
145                 150                 155                 160 
His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly
                165                 170                 175     
Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu
            180                 185                 190         
Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro
        195                 200                 205             
Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly
    210                 215                 220                 
Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe
225                 230                 235                 240 
Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys
                245                 250                 255     
Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu
            260                 265                 270         
Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile
        275                 280                 285             
Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr
    290                 295                 300                 
Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu
305                 310                 315                 320 
Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser
                325                 330                 335     
Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro
            340                 345                 350         
His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg
        355                 360                 365             
Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr
    370                 375                 380                 
Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu
385                 390                 395                 400 
Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile
                405                 410                 415     
Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly
            420                 425                 430         
Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu
        435                 440                 445             
Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro
    450                 455                 460                 
Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr
465                 470                 475                 480 
Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly
                485                 490                 495     
Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr
            500                 505                 510         
Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro
        515                 520                 525             
Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu
    530                 535                 540                 
Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro
545                 550                 555                 560 
Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys
                565                 570                 575     
Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu
            580                 585                 590         
Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala
        595                 600                 605             
Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp
    610                 615                 620                 
Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser
625                 630                 635                 640 
Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val
                645                 650                 655     
Cys Glu Lys Gly Cys Gln Pro Pro Pro Gly Leu His His Gly Arg His
            660                 665                 670         
Thr Gly Gly Asn Thr Val Phe Phe Val Ser Gly Met Thr Val Asp Tyr
        675                 680                 685             
Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys
    690                 695                 700                 
Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Thr
705                 710                 715                 720 
Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg
                725                 730                 735     
Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly
            740                 745                 750         
His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys
        755                 760                 765             
Lys Ile Pro Leu Cys Lys Val Ile Val Asn Gly Lys His Thr Gly Met
    770                 775                 780                 
Met Ala Glu Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr Glu Cys Asp
785                 790                 795                 800 
Gln Gly Phe Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp
                805                 810                 815     
Ser Lys Gly His Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg
            820                 825                 830         
Ser Pro Pro Val Thr Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr
        835                 840                 845             
Lys Leu Asn Lys Thr His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr
    850                 855                 860                 
Val Asp Cys Asn Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg
865                 870                 875                 880 
Cys His Thr Asp Asn Thr Trp Val Pro Gly Val Pro Thr Cys Ile Lys
                885                 890                 895     
Lys Ala Phe Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro Asn Gly Asn
            900                 905                 910         
His Thr Gly Gly Asn Ile Ala Arg Phe Ser Pro Gly Met Ser Ile Leu
        915                 920                 925             
Tyr Ser Cys Asp Gln Gly Tyr Leu Leu Val Gly Glu Ala Leu Leu Leu
    930                 935                 940                 
Cys Thr His Glu Gly Thr Trp Ser Gln Pro Ala Pro His Cys Lys Glu
945                 950                 955                 960 
Val Asn Cys Ser Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu
                965                 970                 975     
Glu Pro Arg Lys Met Tyr Gln Tyr Gly Ala Val Val Thr Leu Glu Cys
            980                 985                 990         
Glu Asp Gly Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser
        995                 1000                1005            
Asp His Gln Trp Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu
    1010                1015                1020                
Ala Pro Val Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Thr Phe
1025                1030                1035                1040
Leu Ile Val Ile Thr Leu Tyr Val Ile Ser Lys His Arg Glu Arg Asn
                1045                1050                1055    
Tyr Tyr Thr Asp Thr Ser Gln Lys Glu Ala Phe His Leu Glu Ala Arg
            1060                1065                1070        
Glu Val Tyr Ser Val Asp Pro Tyr Asn Pro Ala Ser
        1075                1080                


<210> 5858
<211> 331
<212> PRT
<213> Homo sapiens

<400> 5858
Met Ser Ser Thr Pro His Asp Pro Phe Tyr Ser Ser Pro Phe Gly Pro
 1               5                  10                  15      
Phe Tyr Arg Arg His Thr Pro Tyr Met Val Gln Pro Glu Tyr Arg Ile
            20                  25                  30          
Tyr Glu Met Asn Lys Arg Leu Gln Ser Arg Thr Glu Asp Ser Asp Asn
        35                  40                  45              
Leu Trp Trp Asp Ala Phe Ala Thr Glu Phe Phe Glu Asp Asp Ala Thr
    50                  55                  60                  
Leu Thr Leu Ser Phe Cys Leu Glu Asp Gly Pro Lys Arg Tyr Thr Ile
65                  70                  75                  80  
Gly Arg Thr Leu Ile Pro Arg Tyr Phe Ser Thr Val Phe Glu Gly Gly
                85                  90                  95      
Val Thr Asp Leu Tyr Tyr Ile Leu Lys His Ser Lys Glu Ser Tyr His
            100                 105                 110         
Asn Ser Ser Ile Thr Val Asp Cys Asp Gln Cys Thr Met Val Thr Gln
        115                 120                 125             
His Gly Lys Pro Met Phe Thr Lys Val Cys Thr Glu Gly Arg Leu Ile
    130                 135                 140                 
Leu Glu Phe Thr Phe Asp Asp Leu Met Arg Ile Lys Thr Trp His Phe
145                 150                 155                 160 
Thr Ile Arg Gln Tyr Arg Glu Leu Val Pro Arg Ser Ile Leu Ala Met
                165                 170                 175     
His Ala Gln Asp Pro Gln Val Leu Asp Gln Leu Ser Lys Asn Ile Thr
            180                 185                 190         
Arg Met Gly Leu Thr Asn Phe Thr Leu Asn Tyr Leu Arg Leu Cys Val
        195                 200                 205             
Ile Leu Glu Pro Met Gln Glu Leu Met Ser Arg His Lys Thr Tyr Asn
    210                 215                 220                 
Leu Ser Pro Arg Asp Cys Leu Lys Thr Cys Leu Phe Gln Lys Trp Gln
225                 230                 235                 240 
Arg Met Val Ala Pro Pro Ala Glu Pro Thr Arg Gln Pro Thr Thr Lys
                245                 250                 255     
Arg Arg Lys Arg Lys Asn Ser Thr Ser Ser Thr Ser Asn Ser Ser Ala
            260                 265                 270         
Gly Asn Asn Ala Asn Ser Thr Gly Ser Lys Lys Lys Thr Thr Ala Ala
        275                 280                 285             
Asn Leu Ser Leu Ser Ser Gln Val Pro Gly Leu Gly Ala Ile Pro Asn
    290                 295                 300                 
Cys Ser Leu Asn Pro Gly Arg Asp Gly Asp Leu Cys His Ser Thr Ala
305                 310                 315                 320 
Val Thr Pro Ser Gly Gln Phe Lys Glu Lys His
                325                 330     


<210> 5859
<211> 373
<212> PRT
<213> Homo sapiens

<400> 5859
Met Ser Ser Thr Pro His Asp Pro Phe Tyr Ser Ser Pro Phe Gly Pro
 1               5                  10                  15      
Phe Tyr Arg Arg His Thr Pro Tyr Met Val Gln Pro Glu Tyr Arg Ile
            20                  25                  30          
Tyr Glu Met Asn Lys Arg Leu Gln Ser Arg Thr Glu Asp Ser Asp Asn
        35                  40                  45              
Leu Trp Trp Asp Ala Phe Ala Thr Glu Phe Phe Glu Asp Asp Ala Thr
    50                  55                  60                  
Leu Thr Leu Ser Phe Cys Leu Glu Asp Gly Pro Lys Arg Tyr Thr Ile
65                  70                  75                  80  
Gly Arg Thr Leu Ile Pro Arg Tyr Phe Ser Thr Val Phe Glu Gly Gly
                85                  90                  95      
Val Thr Asp Leu Tyr Tyr Ile Leu Lys His Ser Lys Glu Ser Tyr His
            100                 105                 110         
Asn Ser Ser Ile Thr Val Asp Cys Asp Gln Cys Thr Met Val Thr Gln
        115                 120                 125             
His Gly Lys Pro Met Phe Thr Lys Val Cys Thr Glu Gly Arg Leu Ile
    130                 135                 140                 
Leu Glu Phe Thr Phe Asp Asp Leu Met Arg Ile Lys Thr Trp His Phe
145                 150                 155                 160 
Thr Ile Arg Gln Tyr Arg Glu Leu Val Pro Arg Ser Ile Leu Ala Met
                165                 170                 175     
His Ala Gln Asp Pro Gln Val Leu Asp Gln Leu Ser Lys Asn Ile Thr
            180                 185                 190         
Arg Met Gly Leu Thr Asn Phe Thr Leu Asn Tyr Leu Arg Leu Cys Val
        195                 200                 205             
Ile Leu Glu Pro Met Gln Glu Leu Met Ser Arg His Lys Thr Tyr Asn
    210                 215                 220                 
Leu Ser Pro Arg Asp Cys Leu Lys Thr Cys Leu Phe Gln Lys Trp Gln
225                 230                 235                 240 
Arg Met Val Ala Pro Pro Ala Glu Pro Thr Arg Gln Pro Thr Thr Lys
                245                 250                 255     
Arg Arg Lys Arg Lys Asn Ser Thr Ser Ser Thr Ser Asn Ser Ser Ala
            260                 265                 270         
Gly Asn Asn Ala Asn Ser Thr Gly Ser Lys Lys Lys Thr Thr Ala Ala
        275                 280                 285             
Asn Leu Ser Leu Ser Ser Gln Val Pro Asp Val Met Val Val Gly Glu
    290                 295                 300                 
Pro Thr Leu Met Gly Gly Glu Phe Gly Asp Glu Asp Glu Arg Leu Ile
305                 310                 315                 320 
Thr Arg Leu Glu Asn Thr Gln Tyr Asp Ala Ala Asn Gly Met Asp Asp
                325                 330                 335     
Glu Glu Asp Phe Asn Asn Ser Pro Ala Leu Gly Asn Asn Ser Pro Trp
            340                 345                 350         
Asn Ser Lys Pro Pro Ala Thr Gln Glu Thr Lys Ser Glu Asn Pro Pro
        355                 360                 365             
Pro Gln Ala Ser Gln
    370             


<210> 5860
<211> 492
<212> PRT
<213> Homo sapiens

<400> 5860
Met Ala Thr Gly Gly Gly Thr Arg Ser Met Thr Ser Val Tyr Gly His
 1               5                  10                  15      
Leu Leu Gly Leu Gln Lys Leu Asn Leu Leu Asp Cys Ala Ser Tyr Ile
            20                  25                  30          
Thr Gly Leu Ser Gly Ala Thr Trp Thr Met Ala Thr Leu Tyr Arg Asp
        35                  40                  45              
Pro Asp Trp Ser Ser Lys Asn Leu Glu Pro Ala Ile Phe Glu Ala Arg
    50                  55                  60                  
Arg His Val Val Lys Asp Lys Leu Pro Ser Leu Phe Pro Asp Gln Leu
65                  70                  75                  80  
Arg Lys Phe Gln Glu Glu Leu Arg Gln Arg Ser Gln Glu Gly Tyr Arg
                85                  90                  95      
Val Thr Phe Thr Asp Phe Trp Gly Leu Leu Ile Glu Thr Cys Leu Gly
            100                 105                 110         
Asp Glu Arg Asn Glu Cys Lys Leu Ser Asp Gln Arg Ala Pro Leu Ser
        115                 120                 125             
Cys Gly Gln Asn Pro Leu Pro Ile Tyr Leu Thr Ile Asn Val Lys Asp
    130                 135                 140                 
Asp Val Ser Asn Gln Asp Phe Arg Glu Trp Phe Glu Phe Ser Pro Tyr
145                 150                 155                 160 
Glu Val Gly Leu Gln Lys Tyr Gly Ala Phe Ile Pro Ser Glu Leu Phe
                165                 170                 175     
Gly Ser Glu Phe Phe Met Gly Arg Leu Val Lys Arg Ile Pro Glu Ser
            180                 185                 190         
Arg Ile Cys Tyr Met Leu Gly Leu Trp Ser Ser Ile Phe Ser Leu Asn
        195                 200                 205             
Leu Leu Asp Ala Trp Asn Leu Ser His Thr Ser Glu Glu Phe Phe His
    210                 215                 220                 
Arg Trp Thr Arg Glu Lys Val Gln Asp Ile Glu Asp Glu Pro Ile Leu
225                 230                 235                 240 
Pro Glu Ile Pro Lys Cys Asp Ala Asn Ile Leu Glu Thr Thr Val Val
                245                 250                 255     
Ile Pro Gly Ser Trp Leu Ser Asn Ser Phe Arg Glu Ile Leu Thr His
            260                 265                 270         
Arg Ser Phe Val Ser Glu Phe His Asn Phe Leu Ser Gly Leu Gln Leu
        275                 280                 285             
His Thr Asn Tyr Leu Gln Asn Gly Gln Phe Ser Arg Trp Lys Asp Thr
    290                 295                 300                 
Val Leu Asp Gly Phe Pro Asn Gln Leu Ala Glu Ser Ala Asn His Leu
305                 310                 315                 320 
Cys Leu Leu Asp Thr Ala Phe Phe Val Asn Ser Ser Tyr Pro Pro Leu
                325                 330                 335     
Leu Arg Pro Glu Arg Lys Ala Asp Leu Ile Ile His Leu Asn Tyr Cys
            340                 345                 350         
Ala Gly Ser Gln Thr Lys Pro Leu Lys Gln Thr Cys Glu Tyr Cys Thr
        355                 360                 365             
Val Gln Asn Ile Pro Phe Pro Lys Tyr Glu Leu Pro Asp Glu Asn Glu
    370                 375                 380                 
Asn Leu Lys Glu Tyr Tyr Leu Met Glu Asn Pro Gln Glu Pro Asp Ala
385                 390                 395                 400 
Pro Ile Val Thr Phe Phe Pro Leu Ile Asn Asp Thr Phe Arg Lys Tyr
                405                 410                 415     
Lys Ala Pro Gly Val Glu Arg Ser Pro Glu Glu Leu Glu Gln Gly Gln
            420                 425                 430         
Val Asp Ile Tyr Gly Pro Lys Thr Pro Tyr Ala Thr Lys Glu Leu Thr
        435                 440                 445             
Tyr Thr Glu Ala Thr Phe Asp Lys Leu Val Lys Leu Ser Glu Tyr Asn
    450                 455                 460                 
Ile Leu Asn Asn Lys Asp Thr Leu Leu Gln Ala Leu Arg Leu Ala Val
465                 470                 475                 480 
Glu Lys Lys Lys Arg Leu Lys Gly Gln Cys Pro Ser
                485                 490         


<210> 5861
<211> 147
<212> PRT
<213> Homo sapiens

<400> 5861
Cys Thr Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val
 1               5                  10                  15      
Tyr Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr Ile
            20                  25                  30          
Ile Pro Glu Val Pro Gln Leu Thr Asp Leu Ser Phe Val Asp Ile Thr
        35                  40                  45              
Asp Ser Ser Ile Gly Leu Arg Trp Thr Pro Leu Asn Ser Ser Thr Ile
    50                  55                  60                  
Ile Gly Tyr Arg Ile Thr Val Val Ala Ala Gly Glu Gly Ile Pro Ile
65                  70                  75                  80  
Phe Glu Asp Phe Val Asp Ser Ser Val Gly Tyr Tyr Thr Val Thr Gly
                85                  90                  95      
Leu Glu Pro Gly Ile Asp Tyr Asp Ile Ser Val Ile Thr Leu Ile Asn
            100                 105                 110         
Gly Gly Glu Ser Ala Pro Thr Thr Leu Thr Gln Gln Thr Ala Val Pro
        115                 120                 125             
Pro Pro Thr Asp Leu Arg Phe Thr Asn Ile Gly Pro Asp Thr Met Arg
    130                 135                 140                 
Val Thr Trp
145         


<210> 5862
<211> 1237
<212> PRT
<213> Homo sapiens

<400> 5862
Met Gln Lys Ser Val Arg Tyr Asn Glu Gly His Ala Leu Tyr Leu Ala
 1               5                  10                  15      
Phe Leu Ala Arg Lys Glu Gly Thr Lys Arg Gly Phe Leu Ser Lys Lys
            20                  25                  30          
Thr Ala Glu Ala Ser Arg Trp His Glu Lys Trp Phe Ala Leu Tyr Gln
        35                  40                  45              
Asn Val Leu Phe Tyr Phe Glu Gly Glu Gln Ser Cys Arg Pro Ala Gly
    50                  55                  60                  
Met Tyr Leu Leu Glu Gly Cys Ser Cys Glu Arg Thr Pro Ala Pro Pro
65                  70                  75                  80  
Arg Ala Gly Ala Gly Gln Gly Gly Val Arg Asp Ala Leu Asp Lys Gln
                85                  90                  95      
Tyr Tyr Phe Thr Val Leu Phe Gly His Glu Gly Gln Lys Pro Leu Glu
            100                 105                 110         
Leu Arg Cys Glu Glu Glu Gln Asp Gly Lys Glu Trp Met Glu Ala Ile
        115                 120                 125             
His Gln Ala Ser Tyr Ala Asp Ile Leu Ile Glu Arg Glu Val Leu Met
    130                 135                 140                 
Gln Lys Tyr Ile His Leu Val Gln Ile Val Glu Thr Glu Lys Ile Ala
145                 150                 155                 160 
Ala Asn Gln Leu Arg His Gln Leu Glu Asp Gln Asp Thr Glu Ile Glu
                165                 170                 175     
Arg Leu Lys Ser Glu Ile Ile Ala Leu Asn Lys Thr Lys Glu Arg Met
            180                 185                 190         
Arg Pro Tyr Gln Ser Asn Gln Glu Asp Glu Asp Pro Asp Ile Lys Lys
        195                 200                 205             
Ile Lys Lys Val Gln Ser Phe Met Arg Gly Trp Leu Cys Arg Arg Lys
    210                 215                 220                 
Trp Lys Thr Ile Val Gln Asp Tyr Ile Cys Ser Pro His Ala Glu Ser
225                 230                 235                 240 
Met Arg Lys Arg Asn Gln Ile Val Phe Thr Met Val Glu Ala Glu Ser
                245                 250                 255     
Glu Tyr Val His Gln Leu Tyr Ile Leu Val Asn Gly Phe Leu Arg Pro
            260                 265                 270         
Leu Arg Met Ala Ala Ser Ser Lys Lys Pro Pro Ile Ser His Asp Asp
        275                 280                 285             
Val Ser Ser Ile Phe Leu Asn Ser Glu Thr Ile Met Phe Leu His Glu
    290                 295                 300                 
Ile Phe His Gln Gly Leu Lys Ala Arg Ile Ala Asn Trp Pro Thr Leu
305                 310                 315                 320 
Ile Leu Ala Asp Leu Phe Asp Ile Leu Leu Pro Met Leu Asn Ile Tyr
                325                 330                 335     
Gln Glu Phe Val Arg Asn His Gln Tyr Ser Leu Gln Val Leu Ala Asn
            340                 345                 350         
Cys Lys Gln Asn Arg Asp Phe Asp Lys Leu Leu Lys Gln Tyr Glu Ala
        355                 360                 365             
Asn Pro Ala Cys Glu Gly Arg Met Leu Glu Thr Phe Leu Thr Tyr Pro
    370                 375                 380                 
Met Phe Gln Ile Pro Arg Tyr Ile Ile Thr Leu His Glu Leu Leu Ala
385                 390                 395                 400 
His Thr Pro His Glu His Val Glu Arg Lys Ser Leu Glu Phe Ala Lys
                405                 410                 415     
Ser Lys Leu Glu Glu Leu Ser Arg Val Met His Asp Glu Val Ser Asp
            420                 425                 430         
Thr Glu Asn Ile Arg Lys Asn Leu Ala Ile Glu Arg Met Ile Val Glu
        435                 440                 445             
Gly Cys Asp Ile Leu Leu Asp Thr Ser Gln Thr Phe Ile Arg Gln Gly
    450                 455                 460                 
Ser Leu Ile Gln Val Pro Ser Val Glu Arg Gly Lys Leu Ser Lys Val
465                 470                 475                 480 
Arg Leu Gly Ser Leu Ser Leu Lys Lys Glu Gly Glu Arg Gln Cys Phe
                485                 490                 495     
Leu Phe Thr Lys His Phe Leu Ile Cys Thr Arg Ser Ser Gly Gly Lys
            500                 505                 510         
Leu His Leu Leu Lys Thr Gly Gly Val Leu Ser Leu Ile Asp Cys Thr
        515                 520                 525             
Leu Ile Glu Glu Pro Asp Ala Ser Asp Asp Asp Ser Lys Gly Ser Gly
    530                 535                 540                 
Gln Val Phe Gly His Leu Asp Phe Lys Ile Val Val Glu Pro Pro Asp
545                 550                 555                 560 
Arg Ala Ala Phe Thr Val Val Leu Leu Ala Pro Ser Arg Gln Glu Lys
                565                 570                 575     
Ala Ala Trp Met Ser Asp Ile Ser Gln Cys Val Asp Asn Ile Arg Cys
            580                 585                 590         
Asn Gly Leu Met Thr Ile Val Phe Glu Glu Asn Ser Lys Val Thr Val
        595                 600                 605             
Pro His Met Ile Lys Ser Asp Ala Arg Leu His Lys Asp Asp Thr Asp
    610                 615                 620                 
Ile Cys Phe Ser Lys Thr Leu Asn Ser Cys Lys Val Pro Gln Ile Arg
625                 630                 635                 640 
Tyr Ala Ser Val Glu Arg Leu Leu Glu Arg Leu Thr Asp Leu Arg Phe
                645                 650                 655     
Leu Ser Ile Asp Phe Leu Asn Thr Phe Leu His Thr Tyr Arg Ile Phe
            660                 665                 670         
Thr Thr Ala Ala Val Val Leu Gly Lys Leu Ser Asp Ile Tyr Lys Arg
        675                 680                 685             
Pro Phe Thr Ser Ile Pro Val Arg Ser Leu Glu Leu Phe Phe Ala Thr
    690                 695                 700                 
Ser Gln Asn Asn Arg Gly Glu His Leu Val Asp Gly Lys Ser Pro Arg
705                 710                 715                 720 
Leu Cys Arg Lys Phe Ser Ser Pro Pro Pro Leu Ala Val Ser Arg Thr
                725                 730                 735     
Ser Ser Pro Val Arg Ala Arg Lys Leu Ser Leu Thr Ser Pro Leu Asn
            740                 745                 750         
Ser Lys Ile Gly Ala Leu Asp Leu Thr Thr Ser Ser Ser Pro Thr Thr
        755                 760                 765             
Thr Thr Gln Ser Pro Ala Ala Ser Pro Pro Pro His Thr Gly Gln Ile
    770                 775                 780                 
Pro Leu Asp Leu Ser Arg Gly Leu Ser Ser Pro Glu Gln Ser Pro Gly
785                 790                 795                 800 
Thr Val Glu Glu Asn Val Asp Asn Pro Arg Val Asp Leu Cys Asn Lys
                805                 810                 815     
Leu Lys Arg Ser Ile Gln Lys Ala Val Leu Glu Ser Ala Pro Ala Asp
            820                 825                 830         
Arg Ala Gly Val Glu Ser Ser Pro Ala Ala Asp Thr Thr Glu Leu Ser
        835                 840                 845             
Pro Cys Arg Ser Pro Ser Thr Pro Arg His Leu Arg Tyr Arg Gln Pro
    850                 855                 860                 
Gly Gly Gln Thr Ala Asp Asn Ala His Cys Ser Val Ser Pro Ala Ser
865                 870                 875                 880 
Ala Phe Ala Ile Ala Thr Ala Ala Ala Gly His Gly Ser Pro Pro Gly
                885                 890                 895     
Phe Asn Asn Thr Glu Arg Thr Cys Asp Lys Glu Phe Ile Ile Arg Arg
            900                 905                 910         
Thr Ala Thr Asn Arg Val Leu Asn Val Leu Arg His Trp Val Ser Lys
        915                 920                 925             
His Ala Gln Asp Phe Glu Leu Asn Asn Glu Leu Lys Met Asn Val Leu
    930                 935                 940                 
Asn Leu Leu Glu Glu Val Leu Arg Asp Pro Asp Leu Leu Pro Gln Glu
945                 950                 955                 960 
Arg Lys Ala Ala Ala Asn Ile Leu Arg Ala Leu Ser Gln Asp Asp Gln
                965                 970                 975     
Asp Asp Ile His Leu Lys Leu Glu Asp Ile Ile Gln Met Thr Asp Cys
            980                 985                 990         
Met Lys Ala Glu Cys Phe Glu Ser Leu Ser Ala Met Glu Leu Ala Glu
        995                 1000                1005            
Gln Ile Thr Leu Leu Asp His Val Ile Phe Arg Ser Ile Pro Tyr Glu
    1010                1015                1020                
Glu Phe Leu Gly Gln Gly Trp Met Lys Leu Asp Lys Asn Glu Arg Thr
1025                1030                1035                1040
Pro Tyr Ile Met Lys Thr Ser Gln His Phe Asn Asp Met Ser Asn Leu
                1045                1050                1055    
Val Ala Ser Gln Ile Met Asn Tyr Ala Asp Val Ser Ser Arg Ala Asn
            1060                1065                1070        
Ala Ile Glu Lys Trp Val Ala Val Ala Asp Ile Cys Arg Cys Leu His
        1075                1080                1085            
Asn Tyr Asn Gly Val Leu Glu Ile Thr Ser Ala Leu Asn Arg Ser Ala
    1090                1095                1100                
Ile Tyr Arg Leu Lys Lys Thr Trp Ala Lys Val Ser Lys Gln Thr Lys
1105                1110                1115                1120
Ala Leu Met Asp Lys Leu Gln Lys Thr Val Ser Ser Glu Gly Arg Phe
                1125                1130                1135    
Lys Asn Leu Arg Glu Thr Leu Lys Asn Cys Asn Pro Pro Ala Val Pro
            1140                1145                1150        
Tyr Leu Gly Met Tyr Leu Thr Asp Leu Ala Phe Ile Glu Glu Gly Thr
        1155                1160                1165            
Pro Asn Phe Thr Glu Glu Gly Leu Val Asn Phe Ser Lys Met Arg Met
    1170                1175                1180                
Ile Ser His Ile Ile Arg Glu Ile Arg Gln Phe Gln Gln Thr Ser Tyr
1185                1190                1195                1200
Arg Ile Asp His Gln Pro Lys Val Ala Gln Tyr Leu Leu Asp Lys Asp
                1205                1210                1215    
Leu Ile Ile Asp Glu Asp Thr Leu Tyr Glu Leu Ser Leu Lys Ile Glu
            1220                1225                1230        
Pro Arg Leu Pro Ala
        1235        


<210> 5863
<211> 1237
<212> PRT
<213> Homo sapiens

<400> 5863
Met Gln Lys Ser Val Arg Tyr Asn Glu Gly His Ala Leu Tyr Leu Ala
 1               5                  10                  15      
Phe Leu Ala Arg Lys Glu Gly Thr Lys Arg Gly Phe Leu Ser Lys Lys
            20                  25                  30          
Thr Ala Glu Ala Ser Arg Trp His Glu Lys Trp Phe Ala Leu Tyr Gln
        35                  40                  45              
Asn Val Leu Phe Tyr Phe Glu Gly Glu Gln Ser Cys Arg Pro Ala Gly
    50                  55                  60                  
Met Tyr Leu Leu Glu Gly Cys Ser Cys Glu Arg Thr Pro Ala Pro Pro
65                  70                  75                  80  
Arg Ala Gly Ala Gly Gln Gly Gly Val Arg Asp Ala Leu Asp Lys Gln
                85                  90                  95      
Tyr Tyr Phe Thr Val Leu Phe Gly His Glu Gly Gln Lys Pro Leu Glu
            100                 105                 110         
Leu Arg Cys Glu Glu Glu Gln Asp Gly Lys Glu Trp Met Glu Ala Ile
        115                 120                 125             
His Gln Ala Ser Tyr Ala Asp Ile Leu Ile Glu Arg Glu Val Leu Met
    130                 135                 140                 
Gln Lys Tyr Ile His Leu Val Gln Ile Val Glu Thr Glu Lys Ile Ala
145                 150                 155                 160 
Ala Asn Gln Leu Arg His Gln Leu Glu Asp Gln Asp Thr Glu Ile Glu
                165                 170                 175     
Arg Leu Lys Ser Glu Ile Ile Ala Leu Asn Lys Thr Lys Glu Arg Met
            180                 185                 190         
Arg Pro Tyr Gln Ser Asn Gln Glu Asp Glu Asp Pro Asp Ile Lys Lys
        195                 200                 205             
Ile Lys Lys Val Gln Ser Phe Met Arg Gly Trp Leu Cys Arg Arg Lys
    210                 215                 220                 
Trp Lys Thr Ile Val Gln Asp Tyr Ile Cys Ser Pro His Ala Glu Ser
225                 230                 235                 240 
Met Arg Lys Arg Asn Gln Ile Val Phe Thr Met Val Glu Ala Glu Ser
                245                 250                 255     
Glu Tyr Val His Gln Leu Tyr Ile Leu Val Asn Gly Phe Leu Arg Pro
            260                 265                 270         
Leu Arg Met Ala Ala Ser Ser Lys Lys Pro Pro Ile Ser His Asp Asp
        275                 280                 285             
Val Ser Ser Ile Phe Leu Asn Ser Glu Thr Ile Met Phe Leu His Glu
    290                 295                 300                 
Ile Phe His Gln Gly Leu Lys Ala Arg Ile Ala Asn Trp Pro Thr Leu
305                 310                 315                 320 
Ile Leu Ala Asp Leu Phe Asp Ile Leu Leu Pro Met Leu Asn Ile Tyr
                325                 330                 335     
Gln Glu Phe Val Arg Asn His Gln Tyr Ser Leu Gln Val Leu Ala Asn
            340                 345                 350         
Cys Lys Gln Asn Arg Asp Phe Asp Lys Leu Leu Lys Gln Tyr Glu Ala
        355                 360                 365             
Asn Pro Ala Cys Glu Gly Arg Met Leu Glu Thr Phe Leu Thr Tyr Pro
    370                 375                 380                 
Met Phe Gln Ile Pro Arg Tyr Ile Ile Thr Leu His Glu Leu Leu Ala
385                 390                 395                 400 
His Thr Pro His Glu His Val Glu Arg Lys Ser Leu Glu Phe Ala Lys
                405                 410                 415     
Ser Lys Leu Glu Glu Leu Ser Arg Val Met His Asp Glu Val Ser Asp
            420                 425                 430         
Thr Glu Asn Ile Arg Lys Asn Leu Ala Ile Glu Arg Met Ile Val Glu
        435                 440                 445             
Gly Cys Asp Ile Leu Leu Asp Thr Ser Gln Thr Phe Ile Arg Gln Gly
    450                 455                 460                 
Ser Leu Ile Gln Val Pro Ser Val Glu Arg Gly Lys Leu Ser Lys Val
465                 470                 475                 480 
Arg Leu Gly Ser Leu Ser Leu Lys Lys Glu Gly Glu Arg Gln Cys Phe
                485                 490                 495     
Leu Phe Thr Lys His Phe Leu Ile Cys Thr Arg Ser Ser Gly Gly Lys
            500                 505                 510         
Leu His Leu Leu Lys Thr Gly Gly Val Leu Ser Leu Ile Asp Cys Thr
        515                 520                 525             
Leu Ile Glu Glu Pro Asp Ala Ser Asp Asp Asp Ser Lys Gly Ser Gly
    530                 535                 540                 
Gln Val Phe Gly His Leu Asp Phe Lys Ile Val Val Glu Pro Pro Asp
545                 550                 555                 560 
Ala Ala Ala Phe Thr Val Val Leu Leu Ala Pro Ser Arg Gln Glu Lys
                565                 570                 575     
Ala Ala Trp Met Ser Asp Ile Ser Gln Cys Val Asp Asn Ile Arg Cys
            580                 585                 590         
Asn Gly Leu Met Thr Ile Val Phe Glu Glu Asn Ser Lys Val Thr Val
        595                 600                 605             
Pro His Met Ile Lys Ser Asp Ala Arg Leu His Lys Asp Asp Thr Asp
    610                 615                 620                 
Ile Cys Phe Ser Lys Thr Leu Asn Ser Cys Lys Val Pro Gln Ile Arg
625                 630                 635                 640 
Tyr Ala Ser Val Glu Arg Leu Leu Glu Arg Leu Thr Asp Leu Arg Phe
                645                 650                 655     
Leu Ser Ile Asp Phe Leu Asn Thr Phe Leu His Thr Tyr Arg Ile Phe
            660                 665                 670         
Thr Thr Ala Ala Val Val Leu Gly Lys Leu Ser Asp Ile Tyr Lys Arg
        675                 680                 685             
Pro Phe Thr Ser Ile Pro Val Arg Ser Leu Glu Leu Phe Phe Ala Thr
    690                 695                 700                 
Ser Gln Asn Asn Arg Gly Glu His Leu Val Asp Gly Lys Ser Pro Arg
705                 710                 715                 720 
Leu Cys Arg Lys Phe Ser Ser Pro Pro Pro Leu Ala Val Ser Arg Thr
                725                 730                 735     
Ser Ser Pro Val Arg Ala Arg Lys Leu Ser Leu Thr Ser Pro Leu Asn
            740                 745                 750         
Ser Lys Ile Gly Ala Leu Asp Leu Thr Thr Ser Ser Ser Pro Thr Thr
        755                 760                 765             
Thr Thr Gln Ser Pro Ala Ala Ser Pro Pro Pro His Thr Gly Gln Ile
    770                 775                 780                 
Pro Leu Asp Leu Ser Arg Gly Leu Ser Ser Pro Glu Gln Ser Pro Gly
785                 790                 795                 800 
Thr Val Glu Glu Asn Val Asp Asn Pro Arg Val Asp Leu Cys Asn Lys
                805                 810                 815     
Leu Lys Arg Ser Ile Gln Lys Ala Val Leu Glu Ser Ala Pro Ala Asp
            820                 825                 830         
Arg Ala Gly Val Glu Ser Ser Pro Ala Ala Asp Thr Thr Glu Leu Ser
        835                 840                 845             
Pro Cys Arg Ser Pro Ser Thr Pro Arg His Leu Arg Tyr Arg Gln Pro
    850                 855                 860                 
Gly Gly Gln Thr Ala Asp Asn Ala His Cys Ser Val Ser Pro Ala Ser
865                 870                 875                 880 
Ala Phe Ala Ile Ala Thr Ala Ala Ala Gly His Gly Ser Pro Pro Gly
                885                 890                 895     
Phe Asn Asn Thr Glu Arg Thr Cys Asp Lys Glu Phe Ile Ile Arg Arg
            900                 905                 910         
Thr Ala Thr Asn Arg Val Leu Asn Val Leu Arg His Trp Val Ser Lys
        915                 920                 925             
His Ala Gln Asp Phe Glu Leu Asn Asn Glu Leu Lys Met Asn Val Leu
    930                 935                 940                 
Asn Leu Leu Glu Glu Val Leu Arg Asp Pro Asp Leu Leu Pro Gln Glu
945                 950                 955                 960 
Arg Lys Ala Ala Ala Asn Ile Leu Arg Ala Leu Ser Gln Asp Asp Gln
                965                 970                 975     
Asp Asp Ile His Leu Lys Leu Glu Asp Ile Ile Gln Met Thr Asp Cys
            980                 985                 990         
Met Lys Ala Glu Cys Phe Glu Ser Leu Ser Ala Met Glu Leu Ala Glu
        995                 1000                1005            
Gln Ile Thr Leu Leu Asp His Val Ile Phe Arg Ser Ile Pro Tyr Glu
    1010                1015                1020                
Glu Phe Leu Gly Gln Gly Trp Met Lys Leu Asp Lys Asn Glu Arg Thr
1025                1030                1035                1040
Pro Tyr Ile Met Lys Thr Ser Gln His Phe Asn Asp Met Ser Asn Leu
                1045                1050                1055    
Val Ala Ser Gln Ile Met Asn Tyr Ala Asp Val Ser Ser Arg Ala Asn
            1060                1065                1070        
Ala Ile Glu Lys Trp Val Ala Val Ala Asp Ile Cys Arg Cys Leu His
        1075                1080                1085            
Asn Tyr Asn Gly Val Leu Glu Ile Thr Ser Ala Leu Asn Arg Ser Ala
    1090                1095                1100                
Ile Tyr Arg Leu Lys Lys Thr Trp Ala Lys Val Ser Lys Gln Thr Lys
1105                1110                1115                1120
Ala Leu Met Asp Lys Leu Gln Lys Thr Val Ser Ser Glu Gly Arg Phe
                1125                1130                1135    
Lys Asn Leu Arg Glu Thr Leu Lys Asn Cys Asn Pro Pro Ala Val Pro
            1140                1145                1150        
Tyr Leu Gly Met Tyr Leu Thr Asp Leu Ala Phe Ile Glu Glu Gly Thr
        1155                1160                1165            
Pro Asn Phe Thr Glu Glu Gly Leu Val Asn Phe Ser Lys Met Arg Met
    1170                1175                1180                
Ile Ser His Ile Ile Arg Glu Ile Arg Gln Phe Gln Gln Thr Ser Tyr
1185                1190                1195                1200
Arg Ile Asp His Gln Pro Lys Val Ala Gln Tyr Leu Leu Asp Lys Asp
                1205                1210                1215    
Leu Ile Ile Asp Glu Asp Thr Leu Tyr Glu Leu Ser Leu Lys Ile Glu
            1220                1225                1230        
Pro Arg Leu Pro Ala
        1235        


<210> 5864
<211> 713
<212> PRT
<213> Homo sapiens

<400> 5864
Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val
 1               5                  10                  15      
Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln
            20                  25                  30          
Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln
        35                  40                  45              
Ser Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu
    50                  55                  60                  
Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly
65                  70                  75                  80  
Leu Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val
                85                  90                  95      
His Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val
            100                 105                 110         
Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala
        115                 120                 125             
Arg Thr Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro
    130                 135                 140                 
Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly
145                 150                 155                 160 
Lys Val Val Asp Ser Asp Arg Pro Glu Arg Ser Lys Phe Arg Leu Thr
                165                 170                 175     
Gly Lys Gly Val Asp Gln Glu Pro Lys Gly Ile Phe Arg Ile Asn Glu
            180                 185                 190         
Asn Thr Gly Ser Val Ser Val Thr Arg Thr Leu Asp Arg Glu Val Ile
        195                 200                 205             
Ala Val Tyr Gln Leu Phe Val Glu Thr Thr Asp Val Asn Gly Lys Thr
    210                 215                 220                 
Leu Glu Gly Pro Val Pro Leu Glu Val Ile Val Ile Asp Gln Asn Asp
225                 230                 235                 240 
Asn Arg Pro Ile Phe Arg Glu Gly Pro Tyr Ile Gly His Val Met Glu
                245                 250                 255     
Gly Ser Pro Thr Gly Thr Thr Val Met Arg Met Thr Ala Phe Asp Ala
            260                 265                 270         
Asp Asp Pro Ala Thr Asp Asn Ala Leu Leu Arg Tyr Asn Ile Arg Gln
        275                 280                 285             
Gln Thr Pro Asp Lys Pro Ser Pro Asn Met Phe Tyr Ile Asp Pro Glu
    290                 295                 300                 
Lys Gly Asp Ile Val Thr Val Val Ser Pro Ala Leu Leu Asp Arg Glu
305                 310                 315                 320 
Thr Leu Glu Asn Pro Lys Tyr Glu Leu Ile Ile Glu Ala Gln Asp Met
                325                 330                 335     
Ala Gly Leu Asp Val Gly Leu Thr Gly Thr Ala Thr Ala Thr Ile Met
            340                 345                 350         
Ile Asp Asp Lys Asn Asp His Ser Pro Lys Phe Thr Lys Lys Glu Phe
        355                 360                 365             
Gln Ala Thr Val Glu Glu Gly Ala Val Gly Val Ile Val Asn Leu Thr
    370                 375                 380                 
Val Glu Asp Lys Asp Asp Pro Thr Thr Gly Ala Trp Arg Ala Ala Tyr
385                 390                 395                 400 
Thr Ile Ile Asn Gly Asn Pro Gly Gln Ser Phe Glu Ile His Thr Asn
                405                 410                 415     
Pro Gln Thr Asn Glu Gly Met Leu Ser Val Val Lys Pro Leu Asp Tyr
            420                 425                 430         
Glu Ile Ser Ala Phe His Thr Leu Leu Ile Lys Val Glu Asn Glu Asp
        435                 440                 445             
Pro Leu Val Pro Asp Val Ser Tyr Gly Pro Ser Ser Thr Ala Thr Val
    450                 455                 460                 
His Ile Thr Val Leu Asp Val Asn Glu Gly Pro Val Phe Tyr Pro Asp
465                 470                 475                 480 
Pro Met Met Val Thr Arg Gln Glu Asp Leu Ser Val Gly Ser Val Leu
                485                 490                 495     
Leu Thr Val Asn Ala Thr Asp Pro Asp Ser Leu Gln His Gln Thr Ile
            500                 505                 510         
Arg Tyr Ser Val Tyr Lys Asp Pro Ala Gly Trp Leu Asn Ile Asn Pro
        515                 520                 525             
Ile Asn Gly Thr Val Asp Thr Thr Ala Val Leu Asp Arg Glu Ser Pro
    530                 535                 540                 
Phe Val Asp Asn Ser Val Tyr Thr Ala Leu Phe Leu Ala Ile Asp Ser
545                 550                 555                 560 
Gly Asn Pro Pro Ala Thr Gly Thr Gly Thr Leu Leu Ile Thr Leu Glu
                565                 570                 575     
Asp Val Asn Asp Asn Ala Pro Phe Ile Tyr Pro Thr Val Ala Glu Val
            580                 585                 590         
Cys Asp Asp Ala Lys Asn Leu Ser Val Val Ile Leu Gly Ala Ser Asp
        595                 600                 605             
Lys Asp Leu His Pro Asn Thr Asp Pro Phe Lys Phe Glu Ile His Lys
    610                 615                 620                 
Gln Ala Val Pro Asp Lys Val Trp Lys Ile Ser Lys Ile Asn Asn Thr
625                 630                 635                 640 
His Ala Leu Val Ser Leu Leu Gln Asn Leu Asn Lys Ala Asn Tyr Asn
                645                 650                 655     
Leu Pro Ile Met Val Thr Asp Ser Gly Lys Pro Pro Met Thr Asn Ile
            660                 665                 670         
Thr Asp Leu Arg Val Gln Val Cys Ser Cys Arg Asn Ser Lys Val Asp
        675                 680                 685             
Cys Asn Ala Ala Gly Ala Leu Arg Phe Ser Leu Pro Ser Val Leu Leu
    690                 695                 700                 
Leu Ser Leu Phe Ser Leu Ala Cys Leu
705                 710             


<210> 5865
<211> 1278
<212> PRT
<213> Homo sapiens

<400> 5865
Met Thr Leu Thr Glu Arg Leu Arg Glu Lys Ile Ser Arg Ala Phe Tyr
 1               5                  10                  15      
Asn His Gly Leu Leu Cys Ala Ser Tyr Pro Ile Pro Ile Ile Leu Phe
            20                  25                  30          
Thr Gly Phe Cys Ile Leu Ala Cys Cys Tyr Pro Leu Leu Lys Leu Pro
        35                  40                  45              
Leu Pro Gly Thr Gly Pro Val Glu Phe Thr Thr Pro Val Lys Asp Tyr
    50                  55                  60                  
Ser Pro Pro Pro Val Asp Ser Asp Arg Lys Gln Gly Glu Pro Thr Glu
65                  70                  75                  80  
Gln Pro Glu Trp Tyr Val Gly Ala Pro Val Ala Tyr Val Gln Gln Ile
                85                  90                  95      
Phe Val Lys Ser Ser Val Phe Pro Trp His Lys Asn Leu Leu Ala Val
            100                 105                 110         
Asp Val Phe Arg Ser Pro Leu Ser Arg Ala Phe Gln Leu Val Glu Glu
        115                 120                 125             
Ile Arg Asn His Val Leu Arg Asp Ser Ser Gly Ile Arg Ser Leu Glu
    130                 135                 140                 
Glu Leu Cys Leu Gln Val Thr Asp Leu Leu Pro Gly Leu Arg Lys Leu
145                 150                 155                 160 
Arg Asn Leu Leu Pro Glu His Gly Cys Leu Leu Leu Ser Pro Gly Asn
                165                 170                 175     
Phe Trp Gln Asn Asp Trp Glu Arg Phe His Ala Asp Pro Asp Ile Ile
            180                 185                 190         
Gly Thr Ile His Gln His Glu Pro Lys Thr Leu Gln Thr Ser Ala Thr
        195                 200                 205             
Leu Lys Asp Leu Leu Phe Gly Val Pro Gly Lys Tyr Ser Gly Val Ser
    210                 215                 220                 
Leu Tyr Thr Arg Lys Arg Met Val Ser Tyr Thr Ile Thr Leu Val Phe
225                 230                 235                 240 
Gln His Tyr His Ala Lys Phe Leu Gly Ser Leu Arg Ala Arg Leu Met
                245                 250                 255     
Leu Leu His Pro Ser Pro Asn Cys Ser Leu Arg Ala Glu Ser Leu Val
            260                 265                 270         
His Val His Phe Lys Glu Glu Ile Gly Val Ala Glu Leu Ile Pro Leu
        275                 280                 285             
Val Thr Thr Tyr Ile Ile Leu Phe Ala Tyr Ile Tyr Phe Ser Thr Arg
    290                 295                 300                 
Lys Ile Asp Met Val Lys Ser Lys Trp Gly Leu Ala Leu Ala Ala Val
305                 310                 315                 320 
Val Thr Val Leu Ser Ser Leu Leu Met Ser Val Gly Leu Cys Thr Leu
                325                 330                 335     
Phe Gly Leu Thr Pro Thr Leu Asn Gly Gly Glu Ile Phe Pro Tyr Leu
            340                 345                 350         
Val Val Val Ile Gly Leu Glu Asn Val Leu Val Leu Thr Lys Ser Val
        355                 360                 365             
Val Ser Thr Pro Val Asp Leu Glu Val Lys Leu Arg Ile Ala Gln Gly
    370                 375                 380                 
Leu Ser Ser Glu Ser Trp Ser Ile Met Lys Asn Met Ala Thr Glu Leu
385                 390                 395                 400 
Gly Ile Ile Leu Ile Gly Tyr Phe Thr Leu Val Pro Ala Ile Gln Glu
                405                 410                 415     
Phe Cys Leu Phe Ala Val Val Gly Leu Val Ser Asp Phe Phe Leu Gln
            420                 425                 430         
Met Leu Phe Phe Thr Thr Val Leu Ser Ile Asp Ile Arg Arg Met Glu
        435                 440                 445             
Leu Ala Asp Leu Asn Lys Arg Leu Pro Pro Glu Ala Cys Leu Pro Ser
    450                 455                 460                 
Ala Lys Pro Val Gly Gln Pro Thr Arg Tyr Glu Arg Gln Leu Ala Val
465                 470                 475                 480 
Arg Pro Ser Thr Pro His Thr Ile Thr Leu Gln Pro Ser Ser Phe Arg
                485                 490                 495     
Asn Leu Arg Leu Pro Lys Arg Leu Arg Val Val Tyr Phe Leu Ala Arg
            500                 505                 510         
Thr Arg Leu Ala Gln Arg Leu Ile Met Ala Gly Thr Val Val Trp Ile
        515                 520                 525             
Gly Ile Leu Val Tyr Thr Asp Pro Ala Gly Leu Arg Asn Tyr Leu Ala
    530                 535                 540                 
Ala Gln Val Thr Glu Gln Ser Pro Leu Gly Glu Gly Ala Leu Ala Pro
545                 550                 555                 560 
Met Pro Val Pro Ser Gly Met Leu Pro Pro Ser His Pro Asp Pro Ala
                565                 570                 575     
Phe Ser Ile Phe Pro Pro Asp Ala Pro Lys Leu Pro Glu Asn Gln Thr
            580                 585                 590         
Ser Pro Gly Glu Ser Pro Glu Arg Gly Gly Pro Ala Glu Val Val His
        595                 600                 605             
Asp Ser Pro Val Pro Glu Val Thr Trp Gly Pro Glu Asp Glu Glu Leu
    610                 615                 620                 
Trp Arg Lys Leu Ser Phe Arg His Trp Pro Thr Leu Phe Ser Tyr Tyr
625                 630                 635                 640 
Asn Ile Thr Leu Ala Lys Arg Tyr Ile Ser Leu Leu Pro Val Ile Pro
                645                 650                 655     
Val Thr Leu Arg Leu Asn Pro Arg Glu Ala Leu Glu Gly Arg His Pro
            660                 665                 670         
Gln Asp Gly Arg Ser Ala Trp Pro Pro Pro Gly Pro Ile Pro Ala Gly
        675                 680                 685             
His Trp Glu Ala Gly Pro Lys Gly Pro Gly Gly Val Gln Ala His Gly
    690                 695                 700                 
Asp Val Thr Leu Tyr Lys Val Ala Ala Leu Gly Leu Ala Thr Gly Ile
705                 710                 715                 720 
Val Leu Val Leu Leu Leu Leu Cys Leu Tyr Arg Val Leu Cys Pro Arg
                725                 730                 735     
Asn Tyr Gly Gln Leu Gly Gly Gly Pro Gly Arg Arg Arg Arg Gly Glu
            740                 745                 750         
Leu Pro Cys Asp Asp Tyr Gly Tyr Ala Pro Pro Glu Thr Glu Ile Val
        755                 760                 765             
Pro Leu Val Leu Arg Gly His Leu Met Asp Ile Glu Cys Leu Ala Ser
    770                 775                 780                 
Asp Gly Met Leu Leu Val Ser Cys Cys Leu Ala Gly His Val Cys Val
785                 790                 795                 800 
Trp Asp Ala Gln Thr Gly Asp Cys Leu Thr Arg Ile Pro Arg Pro Gly
                805                 810                 815     
Gln Arg Arg Asp Ser Gly Val Gly Ser Gly Leu Glu Ala Gln Glu Ser
            820                 825                 830         
Trp Glu Arg Leu Ser Asp Gly Gly Lys Ala Gly Pro Glu Glu Pro Gly
        835                 840                 845             
Asp Ser Pro Pro Leu Arg His Arg Pro Arg Gly Pro Pro Pro Pro Ser
    850                 855                 860                 
Leu Phe Gly Asp Gln Pro Asp Leu Thr Cys Leu Ile Asp Thr Asn Phe
865                 870                 875                 880 
Ser Ala Gln Pro Arg Ser Ser Gln Pro Thr Gln Pro Glu Pro Arg His
                885                 890                 895     
Arg Ala Val Cys Gly Arg Ser Arg Asp Ser Pro Gly Tyr Asp Phe Ser
            900                 905                 910         
Cys Leu Val Gln Arg Val Tyr Gln Glu Glu Gly Leu Ala Ala Val Cys
        915                 920                 925             
Thr Pro Ala Leu Arg Pro Pro Ser Pro Gly Pro Val Leu Ser Gln Ala
    930                 935                 940                 
Pro Glu Asp Glu Gly Gly Ser Pro Glu Lys Gly Ser Pro Ser Leu Ala
945                 950                 955                 960 
Trp Ala Pro Ser Ala Glu Gly Ser Ile Trp Ser Leu Glu Leu Gln Gly
                965                 970                 975     
Asn Leu Ile Val Val Gly Arg Ser Ser Gly Arg Leu Glu Val Trp Asp
            980                 985                 990         
Ala Ile Glu Gly Val Leu Cys Cys Ser Ser Glu Glu Val Ser Ser Gly
        995                 1000                1005            
Ile Thr Ala Leu Val Phe Leu Asp Lys Arg Ile Val Ala Ala Arg Leu
    1010                1015                1020                
Asn Gly Ser Leu Asp Phe Phe Ser Leu Glu Thr His Thr Ala Leu Ser
1025                1030                1035                1040
Pro Leu Gln Phe Arg Gly Thr Pro Gly Arg Gly Ser Ser Pro Ala Ser
                1045                1050                1055    
Pro Val Tyr Ser Ser Ser Asp Thr Val Ala Cys His Leu Thr His Thr
            1060                1065                1070        
Val Pro Cys Ala His Gln Lys Pro Ile Thr Ala Leu Lys Ala Ala Ala
        1075                1080                1085            
Gly Arg Leu Val Thr Gly Ser Gln Asp His Thr Leu Arg Val Phe Arg
    1090                1095                1100                
Leu Glu Asp Ser Cys Cys Leu Phe Thr Leu Gln Gly His Ser Gly Ala
1105                1110                1115                1120
Ile Thr Thr Val Tyr Ile Asp Gln Thr Met Val Leu Ala Ser Gly Gly
                1125                1130                1135    
Gln Asp Gly Ala Ile Cys Leu Trp Asp Val Leu Thr Gly Ser Arg Val
            1140                1145                1150        
Ser His Val Phe Ala His Arg Gly Asp Val Thr Ser Leu Thr Cys Thr
        1155                1160                1165            
Thr Ser Cys Val Ile Ser Ser Gly Leu Asp Asp Leu Ile Ser Ile Trp
    1170                1175                1180                
Asp Arg Ser Thr Gly Ile Lys Phe Tyr Ser Ile Gln Gln Asp Leu Gly
1185                1190                1195                1200
Cys Gly Ala Ser Leu Gly Val Ile Ser Asp Asn Leu Leu Val Thr Gly
                1205                1210                1215    
Gly Gln Gly Cys Val Ser Phe Trp Asp Leu Asn Tyr Gly Asp Leu Leu
            1220                1225                1230        
Gln Thr Val Tyr Leu Gly Lys Asn Ser Glu Ala Gln Pro Ala Arg Gln
        1235                1240                1245            
Ile Leu Val Leu Asp Asn Ala Ala Ile Val Cys Asn Phe Gly Ser Glu
    1250                1255                1260                
Leu Ser Leu Val Tyr Val Pro Ser Val Leu Glu Lys Leu Asp
1265                1270                1275            


<210> 5866
<211> 905
<212> PRT
<213> Homo sapiens

<400> 5866
Met Thr Leu Thr Glu Arg Leu Arg Glu Lys Ile Ser Arg Ala Phe Tyr
 1               5                  10                  15      
Asn His Gly Leu Leu Cys Ala Ser Tyr Pro Ile Pro Ile Ile Leu Ile
            20                  25                  30          
Gly Tyr Phe Thr Leu Val Pro Ala Ile Gln Glu Phe Cys Leu Phe Ala
        35                  40                  45              
Val Val Gly Leu Val Ser Asp Phe Phe Leu Gln Met Leu Phe Phe Thr
    50                  55                  60                  
Thr Val Leu Ser Ile Asp Ile Arg Arg Met Glu Leu Ala Asp Leu Asn
65                  70                  75                  80  
Lys Arg Leu Pro Pro Glu Ala Cys Leu Pro Ser Ala Lys Pro Val Gly
                85                  90                  95      
Gln Pro Thr Arg Tyr Glu Arg Gln Leu Ala Val Arg Pro Ser Thr Pro
            100                 105                 110         
His Thr Ile Thr Leu Gln Pro Ser Ser Phe Arg Asn Leu Arg Leu Pro
        115                 120                 125             
Lys Arg Leu Arg Val Val Tyr Phe Leu Ala Arg Thr Arg Leu Ala Gln
    130                 135                 140                 
Arg Leu Ile Met Ala Gly Thr Val Val Trp Ile Gly Ile Leu Val Tyr
145                 150                 155                 160 
Thr Asp Pro Ala Gly Leu Arg Asn Tyr Leu Ala Ala Gln Val Thr Glu
                165                 170                 175     
Gln Ser Pro Leu Gly Glu Gly Ala Leu Ala Pro Met Pro Val Pro Ser
            180                 185                 190         
Gly Met Leu Pro Pro Ser His Pro Asp Pro Ala Phe Ser Ile Phe Pro
        195                 200                 205             
Pro Asp Ala Pro Lys Leu Pro Glu Asn Gln Thr Ser Pro Gly Glu Ser
    210                 215                 220                 
Pro Glu Arg Gly Gly Pro Ala Glu Val Val His Asp Ser Pro Val Pro
225                 230                 235                 240 
Glu Val Thr Trp Gly Pro Glu Asp Glu Glu Leu Trp Arg Lys Leu Ser
                245                 250                 255     
Phe Arg His Trp Pro Thr Leu Phe Ser Tyr Tyr Asn Ile Thr Leu Ala
            260                 265                 270         
Lys Arg Tyr Ile Ser Leu Leu Pro Val Ile Pro Val Thr Leu Arg Leu
        275                 280                 285             
Asn Pro Arg Glu Ala Leu Glu Gly Arg His Pro Gln Asp Gly Arg Ser
    290                 295                 300                 
Ala Trp Pro Pro Pro Gly Pro Ile Pro Ala Gly His Trp Glu Ala Gly
305                 310                 315                 320 
Pro Lys Gly Pro Gly Gly Val Gln Ala His Gly Asp Val Thr Leu Tyr
                325                 330                 335     
Lys Val Ala Ala Leu Gly Leu Ala Thr Gly Ile Val Leu Val Leu Leu
            340                 345                 350         
Leu Leu Cys Leu Tyr Arg Val Leu Cys Pro Arg Asn Tyr Gly Gln Leu
        355                 360                 365             
Gly Gly Gly Pro Gly Arg Arg Arg Arg Gly Glu Leu Pro Cys Asp Asp
    370                 375                 380                 
Tyr Gly Tyr Ala Pro Pro Glu Thr Glu Ile Val Pro Leu Val Leu Arg
385                 390                 395                 400 
Gly His Leu Met Asp Ile Glu Cys Leu Ala Ser Asp Gly Met Leu Leu
                405                 410                 415     
Val Ser Cys Cys Leu Ala Gly His Val Cys Val Trp Asp Ala Gln Thr
            420                 425                 430         
Gly Asp Cys Leu Thr Arg Ile Pro Arg Pro Gly Gln Arg Arg Asp Ser
        435                 440                 445             
Gly Val Gly Ser Gly Leu Glu Ala Gln Glu Ser Trp Glu Arg Leu Ser
    450                 455                 460                 
Asp Gly Gly Lys Ala Gly Pro Glu Glu Pro Gly Asp Ser Pro Pro Leu
465                 470                 475                 480 
Arg His Arg Pro Arg Gly Pro Pro Pro Pro Ser Leu Phe Gly Asp Gln
                485                 490                 495     
Pro Asp Leu Thr Cys Leu Ile Asp Thr Asn Phe Ser Ala Gln Pro Arg
            500                 505                 510         
Ser Ser Gln Pro Thr Gln Pro Glu Pro Arg His Arg Ala Val Cys Gly
        515                 520                 525             
Arg Ser Arg Asp Ser Pro Gly Tyr Asp Phe Ser Cys Leu Val Gln Arg
    530                 535                 540                 
Val Tyr Gln Glu Glu Gly Leu Ala Ala Val Cys Thr Pro Ala Leu Arg
545                 550                 555                 560 
Pro Pro Ser Pro Gly Pro Val Leu Ser Gln Ala Pro Glu Asp Glu Gly
                565                 570                 575     
Gly Ser Pro Glu Lys Gly Ser Pro Ser Leu Ala Trp Ala Pro Ser Ala
            580                 585                 590         
Glu Gly Ser Ile Trp Ser Leu Glu Leu Gln Gly Asn Leu Ile Val Val
        595                 600                 605             
Gly Arg Ser Ser Gly Arg Leu Glu Val Trp Asp Ala Ile Glu Gly Val
    610                 615                 620                 
Leu Cys Cys Ser Ser Glu Glu Val Ser Ser Gly Ile Thr Ala Leu Val
625                 630                 635                 640 
Phe Leu Asp Lys Arg Ile Val Ala Ala Arg Leu Asn Gly Ser Leu Asp
                645                 650                 655     
Phe Phe Ser Leu Glu Thr His Thr Ala Leu Ser Pro Leu Gln Phe Arg
            660                 665                 670         
Gly Thr Pro Gly Arg Gly Ser Ser Pro Ala Ser Pro Val Tyr Ser Ser
        675                 680                 685             
Ser Asp Thr Val Ala Cys His Leu Thr His Thr Val Pro Cys Ala His
    690                 695                 700                 
Gln Lys Pro Ile Thr Ala Leu Lys Ala Ala Ala Gly Arg Leu Val Thr
705                 710                 715                 720 
Gly Ser Gln Asp His Thr Leu Arg Val Phe Arg Leu Glu Asp Ser Cys
                725                 730                 735     
Cys Leu Phe Thr Leu Gln Gly His Ser Gly Ala Ile Thr Thr Val Tyr
            740                 745                 750         
Ile Asp Gln Thr Met Val Leu Ala Ser Gly Gly Gln Asp Gly Ala Ile
        755                 760                 765             
Cys Leu Trp Asp Val Leu Thr Gly Ser Arg Val Ser His Val Phe Ala
    770                 775                 780                 
His Arg Gly Asp Val Thr Ser Leu Thr Cys Thr Thr Ser Cys Val Ile
785                 790                 795                 800 
Ser Ser Gly Leu Asp Asp Leu Ile Ser Ile Trp Asp Arg Ser Thr Gly
                805                 810                 815     
Ile Lys Phe Tyr Ser Ile Gln Gln Asp Leu Gly Cys Gly Ala Ser Leu
            820                 825                 830         
Gly Val Ile Ser Asp Asn Leu Leu Val Thr Gly Gly Gln Gly Cys Val
        835                 840                 845             
Ser Phe Trp Asp Leu Asn Tyr Gly Asp Leu Leu Gln Thr Val Tyr Leu
    850                 855                 860                 
Gly Lys Asn Ser Glu Ala Gln Pro Ala Arg Gln Ile Leu Val Leu Asp
865                 870                 875                 880 
Asn Ala Ala Ile Val Cys Asn Phe Gly Ser Glu Leu Ser Leu Val Tyr
                885                 890                 895     
Val Pro Ser Val Leu Glu Lys Leu Asp
            900                 905 


<210> 5867
<211> 886
<212> PRT
<213> Homo sapiens

<400> 5867
Met Lys Asn Met Ala Thr Glu Leu Gly Ile Ile Leu Ile Gly Tyr Phe
 1               5                  10                  15      
Thr Leu Val Pro Ala Ile Gln Glu Phe Cys Leu Phe Ala Val Val Gly
            20                  25                  30          
Leu Val Ser Asp Phe Phe Leu Gln Met Leu Phe Phe Thr Thr Val Leu
        35                  40                  45              
Ser Ile Asp Ile Arg Arg Met Glu Leu Ala Asp Leu Asn Lys Arg Leu
    50                  55                  60                  
Pro Pro Glu Ala Cys Leu Pro Ser Ala Lys Pro Val Gly Gln Pro Thr
65                  70                  75                  80  
Arg Tyr Glu Arg Gln Leu Ala Val Arg Pro Ser Thr Pro His Thr Ile
                85                  90                  95      
Thr Leu Gln Pro Ser Ser Phe Arg Asn Leu Arg Leu Pro Lys Arg Leu
            100                 105                 110         
Arg Val Val Tyr Phe Leu Ala Arg Thr Arg Leu Ala Gln Arg Leu Ile
        115                 120                 125             
Met Ala Gly Thr Val Val Trp Ile Gly Ile Leu Val Tyr Thr Asp Pro
    130                 135                 140                 
Ala Gly Leu Arg Asn Tyr Leu Ala Ala Gln Val Thr Glu Gln Ser Pro
145                 150                 155                 160 
Leu Gly Glu Gly Ala Leu Ala Pro Met Pro Val Pro Ser Gly Met Leu
                165                 170                 175     
Pro Pro Ser His Pro Asp Pro Ala Phe Ser Ile Phe Pro Pro Asp Ala
            180                 185                 190         
Pro Lys Leu Pro Glu Asn Gln Thr Ser Pro Gly Glu Ser Pro Glu Arg
        195                 200                 205             
Gly Gly Pro Ala Glu Val Val His Asp Ser Pro Val Pro Glu Val Thr
    210                 215                 220                 
Arg Gly Pro Glu Asp Glu Glu Leu Trp Arg Lys Leu Ser Phe Arg His
225                 230                 235                 240 
Trp Pro Thr Leu Phe Ser Tyr Tyr Asn Ile Thr Leu Ala Lys Arg Tyr
                245                 250                 255     
Ile Ser Leu Leu Pro Val Ile Pro Val Thr Leu Arg Leu Asn Pro Arg
            260                 265                 270         
Glu Ala Leu Glu Gly Arg His Pro Gln Asp Gly Arg Ser Ala Trp Pro
        275                 280                 285             
Pro Pro Gly Pro Ile Pro Ala Gly His Trp Glu Ala Gly Pro Lys Gly
    290                 295                 300                 
Pro Gly Gly Val Gln Ala His Gly Asp Val Thr Leu Tyr Lys Val Ala
305                 310                 315                 320 
Ala Leu Gly Leu Ala Thr Gly Ile Val Leu Val Leu Leu Leu Leu Cys
                325                 330                 335     
Leu Tyr Arg Val Leu Cys Pro Arg Asn Tyr Gly Gln Leu Gly Gly Gly
            340                 345                 350         
Pro Gly Arg Arg Arg Arg Gly Glu Gln Pro Cys Asp Asp Tyr Gly Tyr
        355                 360                 365             
Ala Pro Pro Glu Thr Glu Ile Val Pro Leu Val Leu Arg Gly His Leu
    370                 375                 380                 
Met Asp Ile Glu Cys Leu Ala Ser Asp Gly Met Leu Leu Val Ser Cys
385                 390                 395                 400 
Cys Leu Ala Gly His Ile Cys Val Trp Asp Ala Gln Thr Gly Asp Cys
                405                 410                 415     
Leu Thr Arg Ile Pro Arg Pro Gly Gln Arg Arg Asp Ser Gly Val Gly
            420                 425                 430         
Ser Gly Leu Glu Ala Gln Glu Ser Trp Glu Arg Leu Ser Asp Gly Gly
        435                 440                 445             
Lys Ala Gly Pro Glu Glu Pro Gly Asp Ser Pro Pro Leu Arg His Arg
    450                 455                 460                 
Pro Arg Gly Pro Pro Pro Pro Ser Leu Phe Gly Asp Gln Pro Asp Leu
465                 470                 475                 480 
Thr Cys Leu Ile Asp Thr Asn Phe Ser Ala Gln Pro Arg Ser Ser Gln
                485                 490                 495     
Pro Thr Gln Pro Glu Pro Arg His Arg Ala Val Cys Gly Arg Ser Arg
            500                 505                 510         
Asp Ser Pro Gly Tyr Asp Phe Ser Cys Leu Val Gln Arg Val Tyr Gln
        515                 520                 525             
Glu Glu Gly Leu Ala Ala Val Cys Thr Pro Ala Leu Arg Pro Pro Ser
    530                 535                 540                 
Pro Gly Pro Ala Leu Ser Gln Ala Pro Glu Asp Glu Gly Gly Ser Pro
545                 550                 555                 560 
Glu Lys Gly Ser Pro Ser Leu Ala Trp Ala Pro Ser Ala Glu Gly Ser
                565                 570                 575     
Ile Trp Ser Leu Glu Leu Gln Gly Asn Leu Ile Val Val Gly Arg Ser
            580                 585                 590         
Ser Gly Arg Leu Glu Val Trp Asp Ala Ile Glu Gly Val Leu Cys Cys
        595                 600                 605             
Ser Ser Glu Glu Val Ser Ser Gly Ile Thr Ala Leu Val Phe Leu Asp
    610                 615                 620                 
Lys Arg Ile Val Ala Ala Arg Leu Asn Gly Ser Leu Asp Phe Phe Ser
625                 630                 635                 640 
Leu Gly Thr His Thr Ala Leu Ser Pro Leu Gln Phe Arg Gly Thr Pro
                645                 650                 655     
Gly Arg Gly Ser Ser Pro Ala Ser Pro Val Tyr Ser Ser Ser Asp Thr
            660                 665                 670         
Val Ala Cys His Leu Thr His Thr Val Pro Cys Ala His Gln Glu Pro
        675                 680                 685             
Ile Thr Ala Leu Lys Ala Ala Ala Gly Arg Leu Val Thr Gly Ser Gln
    690                 695                 700                 
Asp His Thr Leu Arg Val Phe Arg Leu Glu Asp Ser Cys Cys Leu Phe
705                 710                 715                 720 
Thr Leu Gln Gly His Ser Gly Ala Ile Thr Thr Val Tyr Ile Asp Gln
                725                 730                 735     
Thr Met Val Leu Ala Ser Gly Gly Gln Asp Gly Ala Ile Cys Leu Trp
            740                 745                 750         
Asp Val Leu Thr Gly Ser Arg Val Ser His Val Phe Ala His Arg Gly
        755                 760                 765             
Asp Val Thr Ser Leu Thr Cys Thr Thr Ser Cys Val Ile Ser Ser Gly
    770                 775                 780                 
Leu Asp Asp Leu Ile Ser Ile Trp Asp Arg Ser Thr Gly Ile Lys Phe
785                 790                 795                 800 
Tyr Ser Ile Gln Gln Asp Leu Gly Cys Gly Ala Ser Leu Gly Val Ile
                805                 810                 815     
Ser Asp Asn Leu Leu Val Thr Gly Gly Gln Gly Cys Val Ser Phe Trp
            820                 825                 830         
Asp Leu Asn Tyr Gly Asp Leu Leu Gln Thr Val Tyr Leu Gly Lys Asn
        835                 840                 845             
Ser Glu Ala Gln Pro Ala Arg Gln Ile Leu Val Leu Asp Asn Ala Ala
    850                 855                 860                 
Ile Val Cys Asn Phe Gly Ser Glu Leu Ser Leu Val Tyr Val Pro Ser
865                 870                 875                 880 
Val Leu Glu Lys Leu Asp
                885     


<210> 5868
<211> 771
<212> PRT
<213> Homo sapiens

<400> 5868
Met Thr Leu Thr Glu Arg Leu Arg Glu Lys Ile Ser Arg Ala Phe Tyr
 1               5                  10                  15      
Asn His Gly Leu Leu Cys Ala Ser Tyr Pro Ile Pro Ile Ile Leu Phe
            20                  25                  30          
Thr Gly Phe Cys Ile Leu Ala Cys Cys Tyr Pro Leu Leu Lys Leu Pro
        35                  40                  45              
Leu Pro Gly Thr Gly Pro Val Glu Phe Thr Thr Pro Val Lys Asp Tyr
    50                  55                  60                  
Ser Pro Pro Pro Val Asp Ser Asp Arg Lys Gln Gly Glu Pro Thr Glu
65                  70                  75                  80  
Gln Pro Glu Trp Tyr Val Gly Ala Pro Val Ala Tyr Val Gln Gln Ile
                85                  90                  95      
Phe Val Lys Ser Ser Val Phe Pro Trp His Lys Asn Leu Leu Ala Val
            100                 105                 110         
Asp Val Phe Arg Ser Pro Leu Ser Arg Ala Phe Gln Leu Val Glu Glu
        115                 120                 125             
Ile Arg Asn His Val Leu Arg Asp Ser Ser Gly Ile Arg Ser Leu Glu
    130                 135                 140                 
Glu Leu Cys Leu Gln Val Thr Asp Leu Leu Pro Gly Leu Arg Lys Leu
145                 150                 155                 160 
Arg Asn Leu Leu Pro Glu His Gly Cys Leu Leu Leu Ser Pro Gly Asn
                165                 170                 175     
Phe Trp Gln Asn Asp Trp Glu Arg Phe His Ala Asp Pro Asp Ile Ile
            180                 185                 190         
Gly Thr Ile His Gln His Glu Pro Lys Thr Leu Gln Thr Ser Ala Thr
        195                 200                 205             
Leu Lys Asp Leu Leu Phe Gly Val Pro Gly Lys Tyr Ser Gly Val Ser
    210                 215                 220                 
Leu Tyr Thr Arg Lys Arg Met Val Ser Tyr Thr Ile Thr Leu Val Phe
225                 230                 235                 240 
Gln His Tyr His Ala Lys Phe Leu Gly Ser Leu Arg Ala Arg Leu Met
                245                 250                 255     
Leu Leu His Pro Ser Pro Asn Cys Ser Leu Arg Ala Glu Ser Leu Val
            260                 265                 270         
His Val His Phe Lys Glu Glu Ile Gly Val Ala Glu Leu Ile Pro Leu
        275                 280                 285             
Val Thr Thr Tyr Ile Ile Leu Phe Ala Tyr Ile Tyr Phe Ser Thr Arg
    290                 295                 300                 
Lys Ile Asp Met Val Lys Ser Lys Trp Gly Leu Ala Leu Ala Ala Val
305                 310                 315                 320 
Val Thr Val Leu Ser Ser Leu Leu Met Ser Val Gly Leu Cys Thr Leu
                325                 330                 335     
Phe Gly Leu Thr Pro Thr Leu Asn Gly Gly Glu Ile Phe Pro Tyr Leu
            340                 345                 350         
Val Val Val Ile Gly Leu Glu Asn Val Leu Val Leu Thr Lys Ser Val
        355                 360                 365             
Val Ser Thr Pro Val Asp Leu Glu Val Lys Leu Arg Ile Ala Gln Gly
    370                 375                 380                 
Leu Ser Ser Glu Ser Trp Ser Ile Met Lys Asn Met Ala Thr Glu Leu
385                 390                 395                 400 
Gly Ile Ile Leu Ile Gly Tyr Phe Thr Leu Val Pro Ala Ile Gln Glu
                405                 410                 415     
Phe Cys Leu Phe Ala Val Val Gly Leu Val Ser Asp Phe Phe Leu Gln
            420                 425                 430         
Met Leu Phe Phe Thr Thr Val Leu Ser Ile Asp Ile Arg Arg Met Glu
        435                 440                 445             
Leu Ala Asp Leu Asn Lys Arg Leu Pro Pro Glu Ala Cys Leu Pro Ser
    450                 455                 460                 
Ala Lys Pro Val Gly Gln Pro Thr Arg Tyr Glu Arg Ser Ser Gly Arg
465                 470                 475                 480 
Leu Glu Val Trp Asp Ala Ile Glu Gly Val Leu Cys Cys Ser Ser Glu
                485                 490                 495     
Glu Val Ser Ser Gly Ile Thr Ala Leu Val Phe Leu Asp Lys Arg Ile
            500                 505                 510         
Val Ala Ala Arg Leu Asn Gly Ser Leu Asp Phe Phe Ser Leu Glu Thr
        515                 520                 525             
His Thr Ala Leu Ser Pro Leu Gln Phe Arg Gly Thr Pro Gly Arg Gly
    530                 535                 540                 
Ser Ser Pro Ala Ser Pro Val Tyr Ser Ser Ser Asp Thr Val Ala Cys
545                 550                 555                 560 
His Leu Thr His Thr Val Pro Cys Ala His Gln Lys Pro Ile Thr Ala
                565                 570                 575     
Leu Lys Ala Ala Ala Gly Arg Leu Val Thr Gly Ser Gln Asp His Thr
            580                 585                 590         
Leu Arg Val Phe Arg Leu Glu Asp Ser Cys Cys Leu Phe Thr Leu Gln
        595                 600                 605             
Gly His Ser Gly Ala Ile Thr Thr Val Tyr Ile Asp Gln Thr Met Val
    610                 615                 620                 
Leu Ala Ser Gly Gly Gln Asp Gly Ala Ile Cys Leu Trp Asp Val Leu
625                 630                 635                 640 
Thr Gly Ser Arg Val Ser His Val Phe Ala His Arg Gly Asp Val Thr
                645                 650                 655     
Ser Leu Thr Cys Thr Thr Ser Cys Val Ile Ser Ser Gly Leu Asp Asp
            660                 665                 670         
Leu Ile Ser Ile Trp Asp Arg Ser Thr Gly Ile Lys Phe Tyr Ser Ile
        675                 680                 685             
Gln Gln Asp Leu Gly Cys Gly Ala Ser Leu Gly Val Ile Ser Asp Asn
    690                 695                 700                 
Leu Leu Val Thr Gly Gly Gln Gly Cys Val Ser Phe Trp Asp Leu Asn
705                 710                 715                 720 
Tyr Gly Asp Leu Leu Gln Thr Val Tyr Leu Gly Lys Asn Ser Glu Ala
                725                 730                 735     
Gln Pro Ala Arg Gln Ile Leu Val Leu Asp Asn Ala Ala Ile Val Cys
            740                 745                 750         
Asn Phe Gly Ser Glu Leu Ser Leu Val Tyr Val Pro Ser Val Leu Glu
        755                 760                 765             
Lys Leu Asp
    770     


<210> 5869
<211> 152
<212> PRT
<213> Homo sapiens

<400> 5869
Met Glu Glu Leu Asp Arg Gln Lys Ile Gly Gly Phe Trp Arg Glu Val
 1               5                  10                  15      
Gly Val Ala Ser Asp Gln Ser Leu Val Leu Thr Ala Pro Lys Arg Val
            20                  25                  30          
Glu Gly Leu Phe Leu Thr Leu Ser Gly Ser Asn Leu Thr Val Lys Val
        35                  40                  45              
Ala Tyr Asn Ser Ser Gly Ser Cys Glu Ile Glu Lys Ile Val Gly Ser
    50                  55                  60                  
Glu Ile Asp Ser Thr Gly Lys Phe Ala Phe Pro Gly His Arg Glu Ile
65                  70                  75                  80  
His Val Leu Asp Thr Asp Tyr Glu Gly Tyr Ala Ile Leu Arg Val Ser
                85                  90                  95      
Leu Met Trp Arg Gly Arg Asn Phe Arg Val Leu Lys Tyr Phe Thr Arg
            100                 105                 110         
Ser Leu Glu Asp Lys Asp Arg Leu Gly Phe Trp Lys Phe Arg Glu Leu
        115                 120                 125             
Thr Ala Asp Thr Gly Leu Tyr Leu Ala Ala Arg Pro Gly Arg Cys Ala
    130                 135                 140                 
Glu Leu Leu Lys Glu Glu Leu Ile
145                 150         


<210> 5870
<211> 126
<212> PRT
<213> Homo sapiens

<400> 5870
Met Glu Glu Leu Asp Arg Gln Lys Ile Gly Gly Phe Trp Arg Glu Val
 1               5                  10                  15      
Gly Val Ala Ser Asp Gln Ser Leu Val Leu Thr Ala Pro Lys Arg Val
            20                  25                  30          
Glu Gly Leu Phe Leu Thr Leu Ser Gly Ser Asn Leu Thr Val Lys Val
        35                  40                  45              
Ala Tyr Asn Ser Ser Gly Ser Cys Glu Ile Glu Lys Ile Val Gly Ser
    50                  55                  60                  
Glu Ile Asp Ser Thr Gly Lys Phe Ala Phe Pro Gly Lys Cys Ser Cys
65                  70                  75                  80  
Pro Val Met Ala Gly Gly Thr Arg Leu Cys Thr Gln Leu Gly Leu Ile
                85                  90                  95      
Val Pro His Ala Val Pro Cys Thr Val Pro His Ala Val Pro Cys Thr
            100                 105                 110         
Val Leu Cys Ala Val Pro Cys Thr Val Pro His Ala Val Pro
        115                 120                 125     


<210> 5871
<211> 224
<212> PRT
<213> Homo sapiens

<400> 5871
Met His Ser Arg Thr Thr Thr Thr Thr Gln Asp Pro Lys Asn Pro Glu
 1               5                  10                  15      
His Val Lys Thr Phe Thr Phe Asp Leu Ala Tyr Trp Ser His Asn Gly
            20                  25                  30          
Phe Gln Arg Asp Lys Asp Gly Val Leu Ile Ser Ala Asp Pro Ser Arg
        35                  40                  45              
Lys Phe Ala Gly Gln Arg Asp Val Phe His Asp Leu Gly Arg Gly Ile
    50                  55                  60                  
Leu Asp Ser Ala Trp Gln Gly Tyr Asn Ala Thr Leu Leu Ala Tyr Gly
65                  70                  75                  80  
Gln Thr Gly Ser Gly Lys Ser Tyr Ser Met Ile Gly Phe Gly Ala Asn
                85                  90                  95      
Arg Ile Arg Asp Leu Leu Ser Arg Thr Lys Lys Pro Gly Gly Leu Arg
            100                 105                 110         
Ile Arg Glu Asp Gln Gln Leu Gly Phe Tyr Val Glu Gly Leu Lys Ser
        115                 120                 125             
Val Pro Cys Glu Asn Tyr Ala Gln Ile Glu Arg Leu Met Glu Gln Gly
    130                 135                 140                 
Thr Lys Ile Arg Thr Thr Ala Ser Thr Asn Met Asn Ala Ser Ser Ser
145                 150                 155                 160 
Arg Ser His Leu Val Ile Thr Ile Gln Phe Lys Gln Val Phe Leu Asp
                165                 170                 175     
Arg Asp Leu Thr Lys Gln Ser Ser Ile Asn Leu Val Asp Leu Ala Arg
            180                 185                 190         
Ser Glu Arg Gln Lys Ser Ser Gly Ser Glu Gly Asp Arg Leu Arg Glu
        195                 200                 205             
Gly Ser Cys Val Asn Leu Ser Leu Thr Asn Leu Gly Ser Val Ile Arg
    210                 215                 220                 


<210> 5872
<211> 1139
<212> PRT
<213> Homo sapiens

<400> 5872
Met Gln Thr Pro Glu Val Pro Ala Glu Arg Ser Pro Arg Arg Arg Ser
 1               5                  10                  15      
Ile Ser Gly Thr Ser Thr Ser Glu Lys Pro Asn Ser Met Asp Thr Ala
            20                  25                  30          
Asn Thr Ser Pro Phe Lys Val Pro Gly Phe Phe Ser Lys Arg Leu Lys
        35                  40                  45              
Gly Ser Ile Lys Arg Thr Lys Ser Gln Ser Lys Leu Asp Arg Asn Thr
    50                  55                  60                  
Ser Phe Arg Leu Pro Ser Leu Arg Ser Thr Asp Asp Arg Ser Arg Gly
65                  70                  75                  80  
Leu Pro Lys Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser Pro
                85                  90                  95      
Cys Ser Thr Val Glu Cys Leu Asp Leu Gly Arg Gly Glu Pro Val Ser
            100                 105                 110         
Val Lys Pro Leu His Ser Ser Ile Leu Gly Gln Asp Phe Cys Phe Glu
        115                 120                 125             
Val Thr Tyr Leu Ser Gly Ser Lys Cys Phe Ser Cys Asn Ser Ala Ser
    130                 135                 140                 
Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Thr Val Gln Pro Asn
145                 150                 155                 160 
Lys Asp Asn Cys Arg Arg Ala Glu Asn Val Leu Arg Leu Trp Ile Ile
                165                 170                 175     
Glu Ala Lys Asp Leu Ala Pro Lys Lys Lys Tyr Phe Cys Glu Leu Cys
            180                 185                 190         
Leu Asp Asp Thr Leu Phe Ala Arg Thr Thr Ser Lys Thr Lys Ala Asp
        195                 200                 205             
Asn Ile Phe Trp Gly Glu His Phe Glu Phe Phe Ser Leu Pro Pro Leu
    210                 215                 220                 
His Ser Ile Thr Val His Ile Tyr Lys Asp Val Glu Lys Lys Lys Lys
225                 230                 235                 240 
Lys Asp Lys Asn Asn Tyr Val Gly Leu Val Asn Ile Pro Thr Ala Ser
                245                 250                 255     
Val Thr Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Ser Thr Pro
            260                 265                 270         
Thr Pro Asn Lys Gly Lys Thr Gly Gly Pro Ser Ile Arg Ile Lys Ser
        275                 280                 285             
Arg Phe Gln Thr Ile Thr Ile Leu Pro Met Glu Gln Tyr Lys Glu Phe
    290                 295                 300                 
Ala Glu Phe Val Thr Ser Asn Tyr Thr Met Leu Cys Ser Val Leu Glu
305                 310                 315                 320 
Pro Val Ile Ser Val Arg Asn Lys Glu Glu Leu Ala Cys Ala Leu Val
                325                 330                 335     
His Ile Leu Gln Ser Thr Gly Arg Ala Lys Asp Phe Leu Thr Asp Leu
            340                 345                 350         
Val Met Ser Glu Val Asp Arg Cys Gly Glu His Asp Val Leu Ile Phe
        355                 360                 365             
Arg Glu Asn Thr Ile Ala Thr Lys Ser Ile Glu Glu Tyr Leu Lys Leu
    370                 375                 380                 
Val Gly Gln Gln Tyr Leu His Asp Ala Leu Gly Glu Phe Ile Lys Ala
385                 390                 395                 400 
Leu Tyr Glu Ser Asp Glu Asn Cys Glu Val Asp Pro Ser Lys Cys Ser
                405                 410                 415     
Ser Ser Glu Leu Ile Asp His Gln Ser Asn Leu Lys Met Cys Cys Glu
            420                 425                 430         
Leu Ala Phe Cys Lys Ile Ile Asn Ser Tyr Cys Val Phe Pro Arg Glu
        435                 440                 445             
Leu Lys Glu Val Phe Ala Ser Trp Lys Gln Gln Cys Leu Asn Arg Gly
    450                 455                 460                 
Lys Gln Asp Ile Ser Glu Arg Leu Ile Ser Ala Ser Leu Phe Leu Arg
465                 470                 475                 480 
Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe Asn Leu Met Gln
                485                 490                 495     
Glu Tyr Pro Asp Asp Arg Thr Ser Arg Thr Leu Thr Leu Ile Ala Lys
            500                 505                 510         
Val Ile Gln Asn Leu Ala Asn Phe Ala Lys Phe Gly Asn Lys Glu Glu
        515                 520                 525             
Tyr Met Ala Phe Met Asn Asp Phe Leu Glu His Glu Trp Gly Gly Met
    530                 535                 540                 
Lys Arg Phe Leu Leu Glu Ile Ser Asn Pro Asp Thr Ile Ser Asn Thr
545                 550                 555                 560 
Pro Gly Phe Asp Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser Val Leu
                565                 570                 575     
His Ser Leu Leu Trp Glu Val Val Ser Gln Leu Asp Lys Gly Glu Asn
            580                 585                 590         
Ser Phe Leu Gln Ala Thr Val Ala Lys Leu Gly Pro Leu Pro Arg Val
        595                 600                 605             
Leu Ala Asp Ile Thr Lys Ser Leu Thr Asn Pro Thr Pro Ile Gln Gln
    610                 615                 620                 
Gln Leu Arg Arg Phe Thr Glu His Asn Ser Ser Pro Asn Val Ser Gly
625                 630                 635                 640 
Ser Leu Ser Ser Gly Leu Gln Lys Ile Phe Glu Asp Pro Thr Asp Ser
                645                 650                 655     
Asp Leu His Lys Leu Lys Ser Pro Ser Gln Asp Asn Thr Asp Ser Tyr
            660                 665                 670         
Phe Arg Gly Lys Thr Leu Leu Leu Val Gln Gln Ala Ser Ser Gln Ser
        675                 680                 685             
Met Thr Tyr Ser Glu Lys Asp Glu Arg Glu Ser Ser Leu Pro Asn Gly
    690                 695                 700                 
Arg Ser Val Ser Leu Met Asp Leu Gln Asp Thr His Ala Ala Gln Val
705                 710                 715                 720 
Glu His Ala Ser Val Met Leu Asp Val Pro Ile Arg Leu Thr Gly Ser
                725                 730                 735     
Gln Leu Ser Ile Thr Gln Val Ala Ser Ile Lys Gln Leu Arg Glu Thr
            740                 745                 750         
Gln Ser Thr Pro Gln Ser Ala Pro Gln Val Arg Arg Pro Leu His Pro
        755                 760                 765             
Ala Leu Asn Gln Pro Gly Gly Leu Gln Pro Leu Ser Phe Gln Asn Pro
    770                 775                 780                 
Val Tyr His Leu Asn Asn Pro Ile Pro Ala Met Pro Lys Ala Ser Ile
785                 790                 795                 800 
Asp Ser Ser Leu Glu Asn Leu Ser Thr Ala Ser Ser Arg Ser Gln Ser
                805                 810                 815     
Asn Ser Glu Asp Phe Lys Leu Ser Gly Pro Ser Asn Ser Ser Met Glu
            820                 825                 830         
Asp Phe Thr Lys Arg Ser Thr Gln Ser Glu Asp Phe Ser Arg Arg His
        835                 840                 845             
Thr Val Pro Asp Arg His Ile Pro Leu Ala Leu Pro Arg Gln Asn Ser
    850                 855                 860                 
Thr Gly Gln Ala Gln Ile Arg Lys Val Asp Gln Gly Gly Leu Gly Ala
865                 870                 875                 880 
Arg Ala Lys Ala Pro Pro Ser Leu Pro His Ser Ala Ser Leu Arg Ser
                885                 890                 895     
Thr Gly Ser Met Ser Val Val Ser Ala Ala Leu Val Ala Glu Pro Val
            900                 905                 910         
Gln Asn Gly Ser Arg Ser Arg Gln Gln Ser Ser Ser Ser Arg Glu Ser
        915                 920                 925             
Pro Val Pro Lys Val Arg Ala Ile Gln Arg Gln Gln Thr Gln Gln Val
    930                 935                 940                 
Gln Ser Pro Val Asp Ser Ala Thr Met Ser Pro Val Glu Arg Thr Ala
945                 950                 955                 960 
Ala Trp Val Leu Asn Asn Gly Gln Tyr Glu Glu Asp Val Glu Glu Thr
                965                 970                 975     
Glu Gln Asn Leu Asp Glu Ala Lys His Ala Glu Lys Tyr Glu Gln Glu
            980                 985                 990         
Ile Thr Lys Leu Lys Glu Arg Leu Arg Val Ser Ser Arg Arg Leu Glu
        995                 1000                1005            
Glu Tyr Glu Arg Arg Leu Leu Val Gln Glu Gln Gln Met Gln Lys Leu
    1010                1015                1020                
Leu Leu Glu Tyr Lys Ala Arg Leu Glu Asp Ser Glu Glu Arg Leu Arg
1025                1030                1035                1040
Arg Gln Gln Glu Glu Lys Asp Ser Gln Met Lys Ser Ile Ile Ser Arg
                1045                1050                1055    
Leu Met Ala Val Glu Glu Glu Leu Lys Lys Asp His Ala Glu Met Gln
            1060                1065                1070        
Ala Val Ile Asp Ala Lys Gln Lys Ile Ile Asp Ala Gln Glu Lys Arg
        1075                1080                1085            
Ile Val Ser Leu Asp Ser Ala Asn Thr Arg Leu Met Ser Ala Leu Thr
    1090                1095                1100                
Gln Val Lys Glu Arg Tyr Ser Met Gln Val Arg Asn Gly Ile Ser Pro
1105                1110                1115                1120
Thr Asn Pro Thr Lys Leu Ser Ile Thr Glu Asn Gly Glu Phe Lys Asn
                1125                1130                1135    
Ser Ser Cys
            


<210> 5873
<211> 1269
<212> PRT
<213> Homo sapiens

<400> 5873
Met Phe Pro Ala Leu Glu Ser Asp Ser Pro Leu Pro Pro Glu Asp Leu
 1               5                  10                  15      
Asp Ala Val Val Pro Val Ser Gly Ala Val Ala Gly Gly Met Leu Asp
            20                  25                  30          
Arg Ile Leu Leu Glu Ser Val Cys Gln Gln Gln Ser Trp Val Arg Val
        35                  40                  45              
Tyr Asp Gly Lys Gly Pro Pro Thr His Arg Leu Ser Cys Gly Gln Ser
    50                  55                  60                  
Pro Tyr Thr Glu Thr Thr Thr Trp Glu Arg Lys Tyr Cys Ile Leu Thr
65                  70                  75                  80  
Asp Ser Gln Leu Val Leu Leu Asn Lys Glu Lys Glu Ile Pro Val Glu
                85                  90                  95      
Gly Gly Gln Glu Gln Gln Thr Asp Ser Thr Lys Gly Arg Cys Leu Arg
            100                 105                 110         
Arg Thr Val Ser Val Pro Ser Glu Gly Gln Phe Pro Glu Tyr Pro Pro
        115                 120                 125             
Glu Gly Ala Thr Lys Leu Glu Val Pro Ala Glu Arg Ser Pro Arg Arg
    130                 135                 140                 
Arg Ser Ile Ser Gly Thr Ser Thr Ser Glu Lys Pro Asn Ser Met Asp
145                 150                 155                 160 
Thr Ala Asn Thr Ser Pro Phe Lys Val Pro Gly Phe Phe Ser Lys Arg
                165                 170                 175     
Leu Lys Gly Ser Ile Lys Arg Thr Lys Ser Gln Ser Lys Leu Asp Arg
            180                 185                 190         
Asn Thr Ser Phe Arg Leu Pro Ser Leu Arg Ser Thr Asp Asp Arg Ser
        195                 200                 205             
Arg Gly Leu Pro Lys Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu
    210                 215                 220                 
Ser Pro Cys Ser Thr Val Glu Cys Leu Asp Leu Gly Arg Gly Glu Pro
225                 230                 235                 240 
Val Ser Val Lys Pro Leu His Ser Ser Ile Leu Gly Gln Asp Phe Cys
                245                 250                 255     
Phe Glu Val Thr Tyr Leu Ser Gly Ser Lys Cys Phe Ser Cys Asn Ser
            260                 265                 270         
Ala Ser Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Thr Val Gln
        275                 280                 285             
Pro Asn Lys Asp Asn Cys Arg Arg Ala Glu Asn Val Leu Arg Leu Trp
    290                 295                 300                 
Ile Ile Glu Ala Lys Asp Leu Ala Pro Lys Lys Lys Tyr Phe Cys Glu
305                 310                 315                 320 
Leu Cys Leu Asp Asp Thr Leu Phe Ala Arg Thr Thr Ser Lys Thr Lys
                325                 330                 335     
Ala Asp Asn Ile Phe Trp Gly Glu His Phe Glu Phe Phe Ser Leu Pro
            340                 345                 350         
Pro Leu His Ser Ile Thr Val His Ile Tyr Lys Asp Val Glu Lys Lys
        355                 360                 365             
Lys Lys Lys Asp Lys Asn Asn Tyr Val Gly Leu Val Asn Ile Pro Thr
    370                 375                 380                 
Ala Ser Val Thr Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Ser
385                 390                 395                 400 
Thr Pro Thr Pro Asn Lys Gly Lys Thr Gly Gly Pro Ser Ile Arg Ile
                405                 410                 415     
Lys Ser Arg Phe Gln Thr Ile Thr Ile Leu Pro Met Glu Gln Tyr Lys
            420                 425                 430         
Glu Phe Ala Glu Phe Val Thr Ser Asn Tyr Thr Met Leu Cys Ser Val
        435                 440                 445             
Leu Glu Pro Val Ile Ser Val Arg Asn Lys Glu Glu Leu Ala Cys Ala
    450                 455                 460                 
Leu Val His Ile Leu Gln Ser Thr Gly Arg Ala Lys Asp Phe Leu Thr
465                 470                 475                 480 
Asp Leu Val Met Ser Glu Val Asp Arg Cys Gly Glu His Asp Val Leu
                485                 490                 495     
Ile Phe Arg Glu Asn Thr Ile Ala Thr Lys Ser Ile Glu Glu Tyr Leu
            500                 505                 510         
Lys Leu Val Gly Gln Gln Tyr Leu His Asp Ala Leu Gly Glu Phe Ile
        515                 520                 525             
Lys Ala Leu Tyr Glu Ser Asp Glu Asn Cys Glu Val Asp Pro Ser Lys
    530                 535                 540                 
Cys Ser Ser Ser Glu Leu Ile Asp His Gln Ser Asn Leu Lys Met Cys
545                 550                 555                 560 
Cys Glu Leu Ala Phe Cys Lys Ile Ile Asn Ser Tyr Cys Val Phe Pro
                565                 570                 575     
Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Lys Gln Gln Cys Leu Asn
            580                 585                 590         
Arg Gly Lys Gln Asp Ile Ser Glu Arg Leu Ile Ser Ala Ser Leu Phe
        595                 600                 605             
Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe Asn Leu
    610                 615                 620                 
Met Gln Glu Tyr Pro Asp Asp Arg Thr Ser Arg Thr Leu Thr Leu Ile
625                 630                 635                 640 
Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ala Lys Phe Gly Asn Lys
                645                 650                 655     
Glu Glu Tyr Met Ala Phe Met Asn Asp Phe Leu Glu His Glu Trp Gly
            660                 665                 670         
Gly Met Lys Arg Phe Leu Leu Glu Ile Ser Asn Pro Asp Thr Ile Ser
        675                 680                 685             
Asn Thr Pro Gly Phe Asp Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser
    690                 695                 700                 
Val Leu His Ser Leu Leu Trp Glu Val Val Ser Gln Leu Asp Lys Gly
705                 710                 715                 720 
Glu Asn Ser Phe Leu Gln Ala Thr Val Ala Lys Leu Gly Pro Leu Pro
                725                 730                 735     
Arg Val Leu Ala Asp Ile Thr Lys Ser Leu Thr Asn Pro Thr Pro Ile
            740                 745                 750         
Gln Gln Gln Leu Arg Arg Phe Thr Glu His Asn Ser Ser Pro Asn Val
        755                 760                 765             
Ser Gly Ser Leu Ser Ser Gly Leu Gln Lys Ile Phe Glu Asp Pro Thr
    770                 775                 780                 
Asp Ser Asp Leu His Lys Leu Lys Ser Pro Ser Gln Asp Asn Thr Asp
785                 790                 795                 800 
Ser Tyr Phe Arg Gly Lys Thr Leu Leu Leu Val Gln Gln Ala Ser Ser
                805                 810                 815     
Gln Ser Met Thr Tyr Ser Glu Lys Asp Glu Arg Glu Ser Ser Leu Pro
            820                 825                 830         
Asn Gly Arg Ser Val Ser Leu Met Asp Leu Gln Asp Thr His Ala Ala
        835                 840                 845             
Gln Val Glu His Ala Ser Val Met Leu Asp Val Pro Ile Arg Leu Thr
    850                 855                 860                 
Gly Ser Gln Leu Ser Ile Thr Gln Val Ala Ser Ile Lys Gln Leu Arg
865                 870                 875                 880 
Glu Thr Gln Ser Thr Pro Gln Ser Ala Pro Gln Val Arg Arg Pro Leu
                885                 890                 895     
His Pro Ala Leu Asn Gln Pro Gly Gly Leu Gln Pro Leu Ser Phe Gln
            900                 905                 910         
Asn Pro Val Tyr His Leu Asn Asn Pro Ile Pro Ala Met Pro Lys Ala
        915                 920                 925             
Ser Ile Asp Ser Ser Leu Glu Asn Leu Ser Thr Ala Ser Ser Arg Ser
    930                 935                 940                 
Gln Ser Asn Ser Glu Asp Phe Lys Leu Ser Gly Pro Ser Asn Ser Ser
945                 950                 955                 960 
Met Glu Asp Phe Thr Lys Arg Ser Thr Gln Ser Glu Asp Phe Ser Arg
                965                 970                 975     
Arg His Thr Val Pro Asp Arg His Ile Pro Leu Ala Leu Pro Arg Gln
            980                 985                 990         
Asn Ser Thr Gly Gln Ala Gln Ile Arg Lys Val Asp Gln Gly Gly Leu
        995                 1000                1005            
Gly Ala Arg Ala Lys Ala Pro Pro Ser Leu Pro His Ser Ala Ser Leu
    1010                1015                1020                
Arg Ser Thr Gly Ser Met Ser Val Val Ser Ala Ala Leu Val Ala Glu
1025                1030                1035                1040
Pro Val Gln Asn Gly Ser Arg Ser Arg Gln Gln Ser Ser Ser Ser Arg
                1045                1050                1055    
Glu Ser Pro Val Pro Lys Val Arg Ala Ile Gln Arg Gln Gln Thr Gln
            1060                1065                1070        
Gln Val Gln Ser Pro Val Asp Ser Ala Thr Met Ser Pro Val Glu Arg
        1075                1080                1085            
Thr Ala Ala Trp Val Leu Asn Asn Gly Gln Tyr Glu Glu Asp Val Glu
    1090                1095                1100                
Glu Thr Glu Gln Asn Leu Asp Glu Ala Lys His Ala Glu Lys Tyr Glu
1105                1110                1115                1120
Gln Glu Ile Thr Lys Leu Lys Glu Arg Leu Arg Val Ser Ser Arg Arg
                1125                1130                1135    
Leu Glu Glu Tyr Glu Arg Arg Leu Leu Val Gln Glu Gln Gln Met Gln
            1140                1145                1150        
Lys Leu Leu Leu Glu Tyr Lys Ala Arg Leu Glu Asp Ser Glu Glu Arg
        1155                1160                1165            
Leu Arg Arg Gln Gln Glu Glu Lys Asp Ser Gln Met Lys Ser Ile Ile
    1170                1175                1180                
Ser Arg Leu Met Ala Val Glu Glu Glu Leu Lys Lys Asp His Ala Glu
1185                1190                1195                1200
Met Gln Ala Val Ile Asp Ala Lys Gln Lys Ile Ile Asp Ala Gln Glu
                1205                1210                1215    
Lys Arg Ile Val Ser Leu Asp Ser Ala Asn Thr Arg Leu Met Ser Ala
            1220                1225                1230        
Leu Thr Gln Val Lys Glu Arg Tyr Ser Met Gln Val Arg Asn Gly Ile
        1235                1240                1245            
Ser Pro Thr Asn Pro Thr Lys Leu Ser Ile Thr Glu Asn Gly Glu Phe
    1250                1255                1260                
Lys Asn Ser Ser Cys
1265                


<210> 5874
<211> 1297
<212> PRT
<213> Homo sapiens

<400> 5874
Met Gln Gln Ala Pro Gln Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ser
 1               5                  10                  15      
Pro Lys Trp Arg Gly Leu Leu Val Ser Ala Leu Arg Lys Val Gln Glu
            20                  25                  30          
Gln Val His Pro Thr Leu Ser Ala Asn Glu Glu Ser Leu Tyr Tyr Ile
        35                  40                  45              
Glu Glu Leu Ile Phe Gln Leu Leu Asn Lys Leu Cys Met Ala Gln Pro
    50                  55                  60                  
Arg Thr Val Gln Asp Val Glu Glu Arg Val Gln Lys Thr Phe Pro His
65                  70                  75                  80  
Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys
                85                  90                  95      
Arg Lys Arg Arg Asn Pro Leu Leu Leu Pro Val Asp Lys Ile His Pro
            100                 105                 110         
Ser Leu Lys Glu Val Leu Gly Tyr Lys Val Asp Tyr His Val Ser Leu
        115                 120                 125             
Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu
    130                 135                 140                 
Ala Gly Asn Tyr Val Phe Asn Ile Arg His Tyr Glu Ile Ser Gln Gln
145                 150                 155                 160 
Asp Ile Lys Val Ser Met Cys Ala Asp Lys Val Leu Met Asp Met Phe
                165                 170                 175     
Asp Gln Asp Asp Ile Gly Leu Val Ser Leu Cys Glu Asp Glu Pro Ser
            180                 185                 190         
Ser Ser Gly Glu Leu Asn Tyr Tyr Asp Leu Val Arg Thr Glu Ile Ala
        195                 200                 205             
Glu Glu Arg Gln Tyr Leu Arg Glu Leu Asn Met Ile Ile Lys Val Phe
    210                 215                 220                 
Arg Glu Ala Phe Leu Ser Asp Arg Lys Leu Phe Lys Pro Ser Asp Ile
225                 230                 235                 240 
Glu Lys Ile Phe Ser Asn Ile Ser Asp Ile His Glu Leu Thr Val Lys
                245                 250                 255     
Leu Leu Gly Leu Ile Glu Asp Thr Val Glu Met Thr Asp Glu Ser Ser
            260                 265                 270         
Pro His Pro Leu Ala Gly Ser Cys Phe Glu Asp Leu Ala Glu Glu Gln
        275                 280                 285             
Ala Phe Asp Pro Tyr Glu Thr Leu Ser Gln Asp Ile Leu Ser Pro Glu
    290                 295                 300                 
Phe His Glu His Phe Asn Lys Leu Met Ala Arg Pro Ala Val Ala Leu
305                 310                 315                 320 
His Phe Gln Ser Ile Ala Asp Gly Phe Lys Glu Ala Val Arg Tyr Val
                325                 330                 335     
Leu Pro Arg Leu Met Leu Val Pro Val Tyr His Cys Trp His Tyr Phe
            340                 345                 350         
Glu Leu Leu Lys Gln Leu Lys Ala Cys Ser Glu Glu Gln Glu Asp Arg
        355                 360                 365             
Glu Cys Leu Asn Gln Ala Ile Thr Ala Leu Met Asn Leu Gln Gly Ser
    370                 375                 380                 
Met Asp Arg Ile Tyr Lys Gln Tyr Ser Pro Arg Arg Arg Pro Gly Asp
385                 390                 395                 400 
Pro Val Cys Pro Phe Tyr Ser His Gln Leu Arg Ser Lys His Leu Ala
                405                 410                 415     
Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp Glu Gly
            420                 425                 430         
Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly Pro Leu
        435                 440                 445             
Thr Arg Ile Gly Ala Lys His Glu Arg His Ile Phe Leu Phe Asp Gly
    450                 455                 460                 
Leu Met Ile Ser Cys Lys Pro Asn His Gly Gln Thr Arg Leu Pro Gly
465                 470                 475                 480 
Tyr Ser Ser Ala Glu Tyr Arg Leu Lys Glu Lys Phe Val Met Arg Lys
                485                 490                 495     
Ile Gln Ile Cys Asp Lys Glu Asp Thr Cys Glu His Lys His Ala Phe
            500                 505                 510         
Glu Leu Val Ser Lys Asp Glu Asn Ser Ile Ile Phe Ala Ala Lys Ser
        515                 520                 525             
Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu His Tyr
    530                 535                 540                 
Arg Ser Thr Leu Asp Arg Met Leu Asp Ser Val Leu Leu Lys Glu Glu
545                 550                 555                 560 
Asn Glu Gln Pro Leu Arg Leu Pro Ser Pro Glu Val Tyr Arg Phe Val
                565                 570                 575     
Val Lys Asp Ser Glu Glu Asn Ile Val Phe Glu Asp Asn Leu Gln Ser
            580                 585                 590         
Arg Ser Gly Ile Pro Ile Ile Lys Gly Gly Thr Val Val Lys Leu Ile
        595                 600                 605             
Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val Arg Thr
    610                 615                 620                 
Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu Leu Ser
625                 630                 635                 640 
Leu Leu Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr Asp Ala
                645                 650                 655     
Asp Lys Leu Ala Ile Glu Lys Gly Glu Gln Pro Ile Ser Ala Asp Leu
            660                 665                 670         
Lys Arg Phe Arg Lys Glu Tyr Val Gln Pro Val Gln Leu Arg Ile Leu
        675                 680                 685             
Asn Val Phe Arg His Trp Val Glu His His Phe Tyr Asp Phe Glu Arg
    690                 695                 700                 
Asp Leu Glu Leu Leu Glu Arg Leu Glu Ser Phe Ile Ser Ser Val Arg
705                 710                 715                 720 
Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Ala Lys Ile Ile Arg
                725                 730                 735     
Arg Lys Lys Gln Ala Gln Ala Asn Gly Val Ser His Asn Ile Thr Phe
            740                 745                 750         
Glu Ser Pro Pro Pro Pro Ile Glu Trp His Ile Ser Lys Pro Gly Gln
        755                 760                 765             
Phe Glu Thr Phe Asp Leu Met Thr Leu His Pro Ile Glu Ile Ala Arg
    770                 775                 780                 
Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Lys Val Gln Pro Ser
785                 790                 795                 800 
Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile Asn Ser
                805                 810                 815     
Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr Leu Trp
            820                 825                 830         
Phe Glu Lys Cys Ile Val Glu Ala Glu Asn Phe Glu Glu Arg Val Ala
        835                 840                 845             
Val Leu Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Asp Leu Asn
    850                 855                 860                 
Asn Phe Asn Gly Val Leu Glu Ile Val Ser Ala Val Asn Ser Val Ser
865                 870                 875                 880 
Val Tyr Arg Leu Asp His Thr Phe Glu Ala Leu Gln Glu Arg Lys Arg
                885                 890                 895     
Lys Ile Leu Asp Glu Ala Val Glu Leu Ser Gln Asp His Phe Lys Lys
            900                 905                 910         
Tyr Leu Val Lys Leu Lys Ser Ile Asn Pro Pro Cys Val Pro Phe Phe
        915                 920                 925             
Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn Asn Asp
    930                 935                 940                 
Phe Leu Lys Lys Lys Gly Lys Asp Leu Ile Asn Phe Ser Lys Arg Arg
945                 950                 955                 960 
Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn Gln Pro
                965                 970                 975     
Tyr Cys Leu Arg Ile Glu Pro Asp Met Arg Arg Phe Phe Glu Asn Leu
            980                 985                 990         
Asn Pro Met Gly Ser Ala Ser Glu Lys Glu Phe Thr Asp Tyr Leu Phe
        995                 1000                1005            
Asn Lys Ser Leu Glu Ile Glu Pro Arg Asn Cys Lys Gln Pro Pro Arg
    1010                1015                1020                
Phe Pro Arg Lys Ser Thr Phe Ser Leu Lys Ser Pro Gly Ile Arg Pro
1025                1030                1035                1040
Asn Thr Gly Arg His Gly Ser Thr Ser Gly Thr Leu Arg Gly His Pro
                1045                1050                1055    
Thr Pro Leu Glu Arg Glu Pro Cys Lys Ile Ser Phe Ser Arg Ile Ala
            1060                1065                1070        
Glu Thr Glu Leu Glu Ser Thr Val Ser Ala Pro Thr Ser Pro Asn Thr
        1075                1080                1085            
Pro Ser Thr Pro Pro Val Ser Ala Ser Ser Asp Leu Ser Val Phe Leu
    1090                1095                1100                
Asp Val Asp Leu Asn Ser Ser Cys Glu Ser Phe Phe Ser Ser Cys Gly
1105                1110                1115                1120
Ser Leu His Lys Leu Ser Glu Glu Pro Leu Ile Pro Pro Pro Leu Pro
                1125                1130                1135    
Pro Arg Lys Lys Phe Asp His Asp Ala Ser Asn Ser Lys Val Lys Pro
            1140                1145                1150        
Arg Val Pro Val Pro Thr Gly Ala Phe Asp Gly Pro Leu His Ser Pro
        1155                1160                1165            
Pro Pro Pro Pro Pro Arg Asp Pro Leu Pro Asp Thr Pro Pro Pro Val
    1170                1175                1180                
Pro Leu Arg Pro Pro Glu His Phe Ile Asn Cys Pro Phe Asn Leu Gln
1185                1190                1195                1200
Pro Pro Pro Leu Gly His Leu His Arg Asp Ser Asp Trp Leu Arg Asp
                1205                1210                1215    
Ile Ser Thr Cys Pro Asn Ser Pro Ser Thr Pro Pro Ser Thr Pro Ser
            1220                1225                1230        
Pro Arg Val Pro Arg Arg Cys Tyr Val Leu Ser Ser Ser Gln Asn Asn
        1235                1240                1245            
Leu Ala His Pro Pro Ala Pro Pro Val Pro Pro Arg Gln Asn Ser Ser
    1250                1255                1260                
Pro His Leu Pro Lys Leu Pro Pro Lys Thr Tyr Lys Arg Glu Leu Ser
1265                1270                1275                1280
His Pro Pro Leu Tyr Arg Leu Pro Leu Leu Glu Asn Ala Glu Thr Pro
                1285                1290                1295    
Gln
    


<210> 5875
<211> 1332
<212> PRT
<213> Homo sapiens

<400> 5875
Met Gln Gln Ala Pro Gln Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ser
 1               5                  10                  15      
Pro Lys Trp Arg Gly Leu Leu Val Ser Ala Leu Arg Lys Val Gln Val
            20                  25                  30          
Gln Val His Pro Thr Leu Ser Ala Asn Glu Glu Ser Leu Tyr Tyr Ile
        35                  40                  45              
Glu Glu Leu Ile Phe Gln Leu Leu Asn Lys Leu Cys Met Ala Gln Pro
    50                  55                  60                  
Arg Thr Val Gln Asp Val Glu Glu Arg Val Gln Lys Thr Phe Pro His
65                  70                  75                  80  
Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys
                85                  90                  95      
Arg Lys Arg Arg Asn Pro Leu Leu Leu Pro Val Asp Lys Ile His Pro
            100                 105                 110         
Ser Leu Lys Glu Val Leu Gly Tyr Lys Val Asp Tyr His Val Ser Leu
        115                 120                 125             
Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu
    130                 135                 140                 
Ala Gly Asn Tyr Val Phe Asn Ile Arg His Tyr Glu Ile Ser Gln Gln
145                 150                 155                 160 
Asp Ile Lys Val Ser Met Cys Ala Asp Lys Val Leu Met Asp Met Phe
                165                 170                 175     
Asp Gln Asp Asp Ile Gly Leu Val Ser Leu Cys Glu Asp Glu Pro Cys
            180                 185                 190         
Ser Ser Gly Glu Leu Asn Tyr Tyr Asp Leu Val Arg Thr Glu Ile Ala
        195                 200                 205             
Glu Glu Arg Gln Tyr Leu Arg Glu Leu Asn Met Ile Ile Lys Val Phe
    210                 215                 220                 
Arg Glu Ala Phe Leu Ser Asp Arg Lys Leu Phe Lys Pro Ser Val Tyr
225                 230                 235                 240 
Glu Lys Ile Phe Ser Asn Ile Ser Asp Ile His Glu Leu Thr Val Lys
                245                 250                 255     
Leu Leu Gly Leu Ile Glu Asp Thr Val Glu Met Thr Asp Glu Ser Ser
            260                 265                 270         
Pro His Pro Leu Ala Gly Ser Cys Phe Glu Asp Leu Ala Glu Glu Gln
        275                 280                 285             
Ala Phe Asp Pro Tyr Glu Thr Leu Ser Gln Asp Ile Leu Ser Pro Glu
    290                 295                 300                 
Phe His Glu His Phe Asn Lys Leu Met Ala Arg Pro Ala Val Ala Leu
305                 310                 315                 320 
His Phe Gln Ser Ile Ala Asp Gly Phe Lys Glu Ala Val Arg Tyr Val
                325                 330                 335     
Leu Pro Arg Leu Met Leu Val Pro Val Tyr His Cys Trp His Tyr Phe
            340                 345                 350         
Glu Leu Leu Lys Gln Leu Lys Ala Cys Ser Glu Glu Gln Glu Asp Arg
        355                 360                 365             
Glu Cys Leu Asn Gln Ala Ile Thr Ala Leu Met Asn His Gln Gly Ser
    370                 375                 380                 
Met Asp Arg Ile Tyr Lys Gln Tyr Ser Pro Arg Arg Arg Pro Gly Asp
385                 390                 395                 400 
Pro Val Cys Pro Phe Tyr Ser His Gln Leu Arg Ser Lys His Leu Ala
                405                 410                 415     
Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp Glu Gly
            420                 425                 430         
Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly Pro Leu
        435                 440                 445             
Thr Arg Ile Gly Ala Lys His Glu Arg His Ile Phe Leu Phe Asp Gly
    450                 455                 460                 
Leu Met Ile Ser Cys Lys Pro Asn His Gly Gln Thr Arg Leu Pro Gly
465                 470                 475                 480 
Tyr Thr Ser Ala Glu Tyr Arg Leu Lys Glu Lys Phe Val Met Arg Lys
                485                 490                 495     
Ile Gln Ile Cys Asp Lys Glu Asp Thr Cys Glu His Lys His Ala Phe
            500                 505                 510         
Glu Leu Val Ser Lys Asp Glu Asn Ser Ile Ile Phe Ala Ala Lys Ser
        515                 520                 525             
Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu His Tyr
    530                 535                 540                 
Arg Ser Thr Leu Asp Arg Met Leu Asp Ser Val Leu Leu Lys Glu Glu
545                 550                 555                 560 
Asn Glu Gln Pro Leu Arg Leu Pro Ser Pro Glu Val Tyr Arg Phe Val
                565                 570                 575     
Val Lys Asp Ser Glu Glu Asn Ile Val Phe Glu Asp Asn Leu Gln Ser
            580                 585                 590         
Arg Ser Gly Ile Pro Ile Ile Lys Gly Gly Thr Val Val Lys Leu Ile
        595                 600                 605             
Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val Arg Thr
    610                 615                 620                 
Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu Leu Ser
625                 630                 635                 640 
Leu Leu Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr Asp Ala
                645                 650                 655     
Asp Lys Leu Ala Ile Glu Lys Gly Glu Gln Pro Ile Ser Ala Asp Leu
            660                 665                 670         
Lys Arg Phe Arg Lys Glu Tyr Val Gln Pro Val Gln Leu Arg Val Leu
        675                 680                 685             
Asn Val Phe Arg His Trp Val Asp His His Tyr Tyr Asp Phe Glu Arg
    690                 695                 700                 
Asp Leu Glu Leu Leu Glu Arg Leu Glu Ser Phe Ile Ser Ser Val Arg
705                 710                 715                 720 
Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Ala Lys Ile Ile Arg
                725                 730                 735     
Arg Lys Lys Gln Ala Gln Ala Asn Gly Val Ser His Asn Ile Thr Phe
            740                 745                 750         
Glu Ser Pro Pro Pro Pro Ile Glu Trp His Ile Ser Lys Pro Gly Gln
        755                 760                 765             
Phe Glu Thr Phe Asp Leu Met Thr Leu Asp Pro Ile Glu Ile Ala Arg
    770                 775                 780                 
Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Lys Val Gln Pro Ser
785                 790                 795                 800 
Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile Asn Ser
                805                 810                 815     
Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr Leu Trp
            820                 825                 830         
Phe Glu Lys Cys Ile Val Glu Ala Glu Asn Phe Glu Glu Arg Val Ala
        835                 840                 845             
Val Leu Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Asp Leu Asn
    850                 855                 860                 
Asn Phe Asn Gly Val Leu Glu Ile Val Ser Ala Val Asn Ser Val Ser
865                 870                 875                 880 
Val Tyr Arg Leu Asp His Thr Phe Glu Ala Leu Gln Glu Arg Lys Arg
                885                 890                 895     
Lys Ile Leu Asp Glu Ala Val Glu Leu Ser Gln Asp His Phe Lys Lys
            900                 905                 910         
Tyr Leu Val Lys Leu Lys Ser Ile Asn Pro Pro Cys Val Pro Phe Phe
        915                 920                 925             
Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn Asn Asp
    930                 935                 940                 
Phe Leu Lys Arg Lys Gly Lys Asp Leu Ile Asn Phe Ser Lys Arg Arg
945                 950                 955                 960 
Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn Gln Pro
                965                 970                 975     
Tyr Cys Leu Arg Ile Glu Pro Asp Met Arg Arg Phe Phe Glu Asn Leu
            980                 985                 990         
Asn Pro Met Gly Ser Ala Ser Glu Lys Glu Phe Thr Asp Tyr Leu Phe
        995                 1000                1005            
Asn Lys Ser Leu Glu Ile Glu Pro Arg Asn Cys Lys Gln Pro Pro Arg
    1010                1015                1020                
Phe Pro Arg Lys Ser Thr Phe Ser Leu Lys Ser Pro Gly Ile Arg Pro
1025                1030                1035                1040
Asn Thr Gly Arg His Gly Ser Thr Ser Gly Thr Leu Arg Gly His Pro
                1045                1050                1055    
Thr Pro Leu Glu Arg Glu Pro Cys Lys Ile Ser Phe Ser Arg Ile Ala
            1060                1065                1070        
Glu Thr Glu Leu Glu Ser Thr Val Ser Ala Pro Thr Ser Pro Asn Thr
        1075                1080                1085            
Pro Ser Thr Pro Pro Val Ser Ala Ser Ser Asp Leu Ser Val Phe Leu
    1090                1095                1100                
Asp Val Asp Leu Asn Ser Ser Cys Gly Ser Asn Ser Ile Phe Ala Pro
1105                1110                1115                1120
Val Leu Leu Pro His Ser Lys Ser Phe Phe Ser Ser Cys Gly Ser Leu
                1125                1130                1135    
His Lys Leu Ser Glu Glu Pro Leu Ile Pro Pro Pro Leu Pro Pro Arg
            1140                1145                1150        
Lys Lys Phe Asp His Asp Ala Ser Asn Ser Lys Gly Asn Met Lys Ser
        1155                1160                1165            
Asp Asp Asp Pro Pro Ala Ile Pro Pro Arg Gln Pro Pro Pro Pro Lys
    1170                1175                1180                
Val Lys Pro Arg Val Pro Val Pro Thr Gly Ala Phe Asp Gly Pro Leu
1185                1190                1195                1200
His Ser Pro Pro Pro Pro Pro Pro Arg Asp Pro Leu Pro Asp Thr Pro
                1205                1210                1215    
Pro Pro Val Pro Leu Arg Pro Pro Glu His Phe Ile Asn Cys Pro Phe
            1220                1225                1230        
Asn Leu Gln Pro Pro Pro Leu Gly His Leu His Arg Asp Ser Asp Trp
        1235                1240                1245            
Leu Arg Asp Ile Ser Thr Cys Pro Asn Ser Pro Ser Thr Pro Pro Ser
    1250                1255                1260                
Thr Pro Ser Pro Arg Val Pro Arg Arg Cys Tyr Val Leu Ser Ser Ser
1265                1270                1275                1280
Gln Asn Asn Leu Ala His Pro Pro Ala Pro Pro Val Pro Pro Arg Gln
                1285                1290                1295    
Asn Ser Ser Pro His Leu Pro Lys Leu Pro Pro Lys Thr Tyr Lys Arg
            1300                1305                1310        
Glu Leu Ser His Pro Pro Leu Tyr Arg Leu Pro Leu Leu Glu Asn Ala
        1315                1320                1325            
Glu Thr Pro Gln
    1330        


<210> 5876
<211> 2205
<212> PRT
<213> Homo sapiens

<400> 5876
Met Ala Val Asn Phe Leu Lys Phe Leu Val Arg Ser Tyr Val Cys Gly
 1               5                  10                  15      
Phe Ala Gly Pro Glu Tyr Ala Asp Val Val Phe Leu Val Asp Ser Ser
            20                  25                  30          
Asp Arg Leu Gly Ser Lys Ser Phe Pro Phe Val Lys Met Phe Ile Thr
        35                  40                  45              
Lys Met Ile Ser Ser Leu Pro Ile Glu Ala Asp Lys Tyr Arg Val Ala
    50                  55                  60                  
Leu Ala Gln Tyr Ser Asp Lys Leu His Ser Glu Phe His Leu Ser Thr
65                  70                  75                  80  
Phe Lys Gly Arg Ser Pro Met Leu Asn His Leu Arg Lys Asn Phe Gly
                85                  90                  95      
Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys Ala Leu Gln Glu Ala His
            100                 105                 110         
Arg Thr Tyr Phe Ser Ala Pro Ala Asn Gly Arg Asp Lys Lys Gln Phe
        115                 120                 125             
Pro Pro Ile Leu Val Val Leu Ala Ser Ser Glu Ser Glu Asp Asn Val
    130                 135                 140                 
Glu Glu Ala Ser Lys Ala Leu Arg Lys Asp Gly Val Lys Ile Ile Ser
145                 150                 155                 160 
Val Gly Val Gln Lys Ala Ser Glu Glu Asn Leu Lys Ala Met Ala Thr
                165                 170                 175     
Ser Gln Phe His Phe Asn Leu Arg Thr Val Arg Asp Leu Ser Met Phe
            180                 185                 190         
Ser Gln Asn Met Thr His Ile Ile Lys Asp Val Ile Lys Tyr Lys Glu
        195                 200                 205             
Gly Ala Val Asp Asp Ile Phe Val Glu Ala Cys Gln Gly Pro Ser Met
    210                 215                 220                 
Ala Asp Val Val Phe Leu Leu Asp Met Ser Ile Asn Gly Ser Glu Glu
225                 230                 235                 240 
Asn Phe Asp Tyr Leu Lys Gly Phe Leu Glu Glu Ser Val Ser Ala Leu
                245                 250                 255     
Asp Ile Lys Glu Asn Cys Met Arg Val Gly Leu Val Ala Tyr Ser Asn
            260                 265                 270         
Glu Thr Lys Val Ile Asn Ser Leu Ser Met Gly Ile Asn Lys Ser Glu
        275                 280                 285             
Val Leu Gln His Ile Gln Asn Leu Ser Pro Arg Thr Gly Lys Ala Tyr
    290                 295                 300                 
Thr Gly Ala Ala Ile Lys Lys Leu Arg Lys Glu Val Phe Ser Ala Arg
305                 310                 315                 320 
Asn Gly Ser Arg Lys Asn Gln Gly Val Pro Gln Ile Ala Val Leu Val
                325                 330                 335     
Thr His Arg Asp Ser Glu Asp Asn Val Thr Lys Ala Ala Val Asn Leu
            340                 345                 350         
Arg Arg Glu Gly Val Thr Ile Phe Thr Leu Gly Ile Glu Gly Ala Ser
        355                 360                 365             
Asp Thr Gln Leu Glu Lys Ile Ala Ser His Pro Ala Glu Gln Tyr Val
    370                 375                 380                 
Ser Lys Leu Lys Thr Phe Ala Asp Leu Ala Ala His Asn Gln Thr Phe
385                 390                 395                 400 
Leu Lys Lys Leu Arg Asn Gln Ile Thr His Thr Val Ser Val Phe Ser
                405                 410                 415     
Glu Arg Thr Glu Thr Leu Lys Ser Gly Cys Val Asp Thr Glu Glu Ala
            420                 425                 430         
Asp Ile Tyr Leu Leu Ile Asp Gly Ser Gly Ser Thr Gln Ala Thr Asp
        435                 440                 445             
Phe His Glu Met Lys Thr Phe Leu Ser Glu Val Val Gly Met Phe Asn
    450                 455                 460                 
Ile Ala Pro His Lys Val Arg Val Gly Ala Val Gln Tyr Ala Asp Ser
465                 470                 475                 480 
Trp Asp Leu Glu Phe Glu Ile Asn Lys Tyr Ser Asn Lys Gln Asp Leu
                485                 490                 495     
Gly Lys Ala Ile Glu Asn Ile Arg Gln Met Gly Gly Asn Thr Asn Thr
            500                 505                 510         
Gly Ala Ala Leu Asn Phe Thr Leu Ser Leu Leu Gln Lys Ala Lys Lys
        515                 520                 525             
Gln Arg Gly Asn Lys Val Pro Cys His Leu Val Val Leu Thr Asn Gly
    530                 535                 540                 
Met Ser Lys Asp Ser Ile Leu Glu Pro Ala Asn Arg Leu Arg Glu Glu
545                 550                 555                 560 
His Ile Arg Val Tyr Ala Ile Gly Ile Lys Glu Ala Asn Gln Thr Gln
                565                 570                 575     
Leu Arg Glu Ile Ala Gly Glu Glu Lys Arg Val Tyr Tyr Val His Asp
            580                 585                 590         
Phe Asp Ala Leu Lys Asp Ile Arg Asn Gln Val Val Gln Glu Ile Cys
        595                 600                 605             
Thr Glu Glu Ala Cys Lys Glu Met Lys Ala Asp Ile Met Phe Leu Val
    610                 615                 620                 
Asp Ser Ser Gly Ser Ile Gly Pro Glu Asn Phe Ser Lys Met Lys Thr
625                 630                 635                 640 
Phe Met Lys Asn Leu Val Ser Lys Ser Gln Ile Gly Pro Asp Arg Val
                645                 650                 655     
Gln Ile Gly Val Val Gln Phe Ser Asp Ile Asn Lys Glu Glu Phe Gln
            660                 665                 670         
Leu Asn Arg Phe Met Ser Gln Ser Asp Ile Ser Asn Ala Ile Asp Gln
        675                 680                 685             
Met Ala His Ile Gly Gln Thr Thr Leu Thr Gly Ser Ala Leu Ser Phe
    690                 695                 700                 
Val Ser Gln Tyr Phe Ser Pro Thr Lys Gly Ala Arg Pro Asn Ile Arg
705                 710                 715                 720 
Lys Phe Leu Ile Leu Ile Thr Asp Gly Glu Ala Gln Asp Ile Val Lys
                725                 730                 735     
Glu Pro Ala Val Val Leu Arg Gln Glu Gly Val Ile Ile Tyr Ser Val
            740                 745                 750         
Gly Val Phe Gly Ser Asn Val Thr Gln Leu Glu Glu Ile Ser Gly Arg
        755                 760                 765             
Pro Glu Met Val Phe Tyr Val Glu Asn Phe Asp Ile Leu Gln Arg Ile
    770                 775                 780                 
Glu Asp Asp Leu Val Phe Gly Ile Cys Ser Pro Arg Glu Glu Cys Lys
785                 790                 795                 800 
Arg Ile Glu Val Leu Asp Val Val Phe Val Ile Asp Ser Ser Gly Ser
                805                 810                 815     
Ile Asp Tyr Asp Glu Tyr Asn Ile Met Lys Asp Phe Met Ile Gly Leu
            820                 825                 830         
Val Lys Lys Ala Asp Val Gly Lys Asn Gln Val Arg Phe Gly Ala Leu
        835                 840                 845             
Lys Tyr Ala Asp Asp Pro Glu Val Leu Phe Tyr Leu Asp Asp Phe Gly
    850                 855                 860                 
Thr Lys Leu Glu Val Ile Ser Val Leu Gln Asn Asp Gln Ala Met Gly
865                 870                 875                 880 
Gly Ser Thr Tyr Thr Ala Glu Ala Leu Gly Phe Ser Asp His Met Phe
                885                 890                 895     
Thr Glu Ala Arg Gly Ser Arg Leu Asn Lys Gly Val Pro Gln Val Leu
            900                 905                 910         
Ile Val Ile Thr Asp Gly Glu Ser His Asp Ala Asp Lys Leu Asn Ala
        915                 920                 925             
Thr Ala Lys Ala Leu Arg Asp Lys Gly Ile Leu Val Leu Ala Val Gly
    930                 935                 940                 
Ile Asp Gly Ala Asn Pro Val Glu Leu Leu Ala Met Ala Gly Ser Ser
945                 950                 955                 960 
Asp Lys Tyr Phe Phe Val Glu Thr Phe Gly Gly Leu Lys Gly Ile Phe
                965                 970                 975     
Ser Asp Val Thr Ala Ser Val Cys Asn Ser Ser Lys Val Asp Cys Glu
            980                 985                 990         
Ile Asp Lys Val Asp Leu Val Phe Leu Met Asp Gly Ser Thr Ser Ile
        995                 1000                1005            
Gln Pro Asn Asp Phe Lys Lys Met Lys Glu Phe Leu Ala Ser Val Val
    1010                1015                1020                
Gln Asp Phe Asp Val Ser Leu Asn Arg Val Arg Ile Gly Ala Ala Gln
1025                1030                1035                1040
Phe Ser Asp Thr Tyr His Pro Glu Phe Pro Leu Gly Thr Phe Ile Gly
                1045                1050                1055    
Glu Lys Glu Ile Ser Phe Gln Ile Glu Asn Ile Lys Gln Ile Phe Gly
            1060                1065                1070        
Asn Thr His Ile Gly Ala Ala Leu Arg Glu Val Glu His Tyr Phe Arg
        1075                1080                1085            
Pro Asp Met Gly Ser Arg Ile Asn Thr Gly Thr Pro Gln Val Leu Leu
    1090                1095                1100                
Val Leu Thr Asp Gly Gln Ser Gln Asp Glu Val Ala Gln Ala Ala Glu
1105                1110                1115                1120
Ala Leu Arg His Arg Gly Ile Asp Ile Tyr Ser Val Gly Ile Gly Asp
                1125                1130                1135    
Val Asp Asp Gln Gln Leu Ile Gln Ile Thr Gly Thr Ala Glu Lys Lys
            1140                1145                1150        
Leu Thr Val His Asn Phe Asp Glu Leu Lys Lys Val Asn Lys Arg Ile
        1155                1160                1165            
Val Arg Asn Ile Cys Thr Thr Ala Gly Glu Ser Ser Val Arg Lys Arg
    1170                1175                1180                
Pro Leu Phe Ala Ile Trp Leu Val Ser Glu Val Glu Glu Gln Cys Leu
1185                1190                1195                1200
Lys Glu Arg Lys Tyr Leu Thr Asp Phe Trp Leu Leu Gly Asn Thr Ala
                1205                1210                1215    
Tyr Arg Ala Ala Lys Ser Cys Gly Thr Asp Cys Phe Val Asp Val Val
            1220                1225                1230        
Val Gly Phe Asp Val Ser Thr Gln Glu Lys Gly Gln Thr Leu Leu Glu
        1235                1240                1245            
Gly Gln Pro Trp Met Glu Thr Tyr Leu Gln Asp Ile Leu Arg Ala Ile
    1250                1255                1260                
Ser Ser Leu Asn Gly Val Ser Cys Glu Val Gly Thr Glu Thr Gln Val
1265                1270                1275                1280
Ser Val Ala Phe Gln Val Thr Asn Ala Met Glu Lys Tyr Ser Pro Lys
                1285                1290                1295    
Phe Glu Ile Tyr Ser Glu Asn Ile Leu Asn Ser Leu Lys Asp Ile Thr
            1300                1305                1310        
Val Lys Gly Pro Ser Leu Leu Asn Ala Asn Leu Leu Asp Ser Leu Trp
        1315                1320                1325            
Asp Thr Phe Gln Asn Lys Ser Ala Ala Arg Gly Lys Val Val Leu Leu
    1330                1335                1340                
Phe Ser Asp Gly Leu Asp Asp Asp Val Glu Lys Leu Glu Gln Lys Ser
1345                1350                1355                1360
Asp Glu Leu Arg Lys Glu Gly Leu Asn Ala Leu Ile Thr Val Ala Leu
                1365                1370                1375    
Asp Gly Pro Ala Asp Ser Ser Asp Leu Ala Asp Leu Pro Tyr Ile Glu
            1380                1385                1390        
Phe Gly Lys Gly Phe Glu Tyr Arg Thr Gln Leu Ser Ile Gly Met Arg
        1395                1400                1405            
Glu Leu Gly Ser Arg Leu Ser Lys Gln Leu Gly Pro Pro Gly Phe Lys
    1410                1415                1420                
Gly Ser Glu Gly Tyr Leu Gly Glu Glu Gly Ile Ala Gly Glu Arg Gly
1425                1430                1435                1440
Ala Pro Gly Pro Val Gly Glu Gln Gly Thr Lys Gly Cys Tyr Gly Thr
                1445                1450                1455    
Lys Gly Pro Lys Gly Asn Arg Gly Leu Asn Gly Gln Glu Gly Glu Val
            1460                1465                1470        
Gly Glu Asn Gly Ile Asp Gly Leu Asn Gly Glu Gln Gly Asp Asn Gly
        1475                1480                1485            
Leu Pro Gly Arg Lys Gly Glu Lys Gly Asp Glu Gly Ser Gln Gly Ser
    1490                1495                1500                
Pro Gly Lys Arg Gly Thr Pro Gly Asp Arg Gly Ala Lys Gly Leu Arg
1505                1510                1515                1520
Gly Asp Pro Gly Ala Pro Gly Val Asp Ser Ser Ile Glu Gly Pro Thr
                1525                1530                1535    
Gly Leu Lys Gly Glu Arg Gly Arg Gln Gly Thr Ala Gly Ile Pro Gly
            1540                1545                1550        
Pro Asp Gly Leu Glu Gly Ser Leu Gly Leu Lys Gly Pro Gln Gly Pro
        1555                1560                1565            
Arg Gly Glu Ala Gly Val Lys Gly Glu Lys Gly Gly Val Gly Ser Lys
    1570                1575                1580                
Gly Pro Gln Gly Glu Pro Gly Asp Leu Gly Glu Lys Gly Ala Val Gly
1585                1590                1595                1600
Phe Pro Gly Pro Arg Gly Leu Gln Gly Asn Asp Gly Ser Pro Gly Tyr
                1605                1610                1615    
Gly Ser Val Gly Arg Lys Gly Ala Lys Gly Gln Glu Gly Phe Pro Gly
            1620                1625                1630        
Glu Ser Gly Pro Lys Gly Glu Ile Gly Asp Pro Gly Gly Pro Gly Glu
        1635                1640                1645            
Thr Gly Leu Lys Gly Ala Arg Gly Lys Met Gly Tyr Gly Leu Leu Gly
    1650                1655                1660                
Lys Pro Glu Cys Pro Val His Pro Thr Glu Leu Val Phe Ala Leu Asp
1665                1670                1675                1680
His Ser Arg Asp Val Thr Glu Gln Glu Phe Glu Arg Met Lys Glu Met
                1685                1690                1695    
Met Ala Phe Leu Val Arg Asp Ile Lys Val Arg Glu Asn Ser Cys Pro
            1700                1705                1710        
Val Gly Ala His Ile Ala Ile Leu Ser Tyr Asn Ser His Ala Arg His
        1715                1720                1725            
Leu Val Arg Phe Ser Asp Ala Tyr Lys Lys Ser Gln Leu Leu Arg Glu
    1730                1735                1740                
Ile Glu Thr Ile Pro Tyr Glu Arg Ser Ser Ala Ser Arg Glu Ile Gly
1745                1750                1755                1760
Arg Ala Met Arg Phe Ile Ser Arg Asn Val Phe Lys Arg Thr Leu Pro
                1765                1770                1775    
Gly Ala His Thr Arg Lys Ile Ala Thr Phe Phe Ser Ser Gly Gln Ser
            1780                1785                1790        
Ala Asp Ala His Ser Ile Thr Thr Ala Ala Met Glu Phe Gly Ala Leu
        1795                1800                1805            
Glu Ile Ile Pro Val Val Ile Thr Phe Ser Asn Val Pro Ser Ile Asp
    1810                1815                1820                
Asp Thr Gly Thr Phe Gln Val Ile Val Val Pro Ser Gly Ala Asp Tyr
1825                1830                1835                1840
Ile Pro Ala Leu Glu Arg Leu Gln Arg Cys Thr Phe Cys Tyr Val Thr
                1845                1850                1855    
Gln Ser Asn Phe Trp Phe Thr Asp Val Cys Lys Pro Asp Ala Ser Cys
            1860                1865                1870        
Asp Gln Ala Arg Pro Pro Pro Val Gln Ser Tyr Met Asp Ala Ala Phe
        1875                1880                1885            
Leu Leu Asp Ala Ser Arg Asn Met Gly Ser Ala Glu Phe Glu Asp Ile
    1890                1895                1900                
Arg Ala Phe Leu Gly Ala Leu Leu Asp His Phe Glu Ile Thr Pro Glu
1905                1910                1915                1920
Pro Glu Thr Ser Val Thr Gly Asp Arg Val Ala Leu Leu Ser His Ala
                1925                1930                1935    
Pro Pro Asp Phe Leu Pro Asn Thr Gln Lys Ser Pro Val Arg Ala Glu
            1940                1945                1950        
Phe Asn Leu Thr Thr Tyr Arg Ser Lys Arg Leu Met Lys Arg His Val
        1955                1960                1965            
His Glu Ser Val Lys Gln Leu Asn Gly Asp Ala Phe Ile Gly His Ala
    1970                1975                1980                
Leu Gln Trp Thr Leu Asp Asn Val Phe Leu Ser Thr Pro Asn Leu Arg
1985                1990                1995                2000
Arg Asn Lys Val Ile Phe Val Ile Ser Ala Gly Glu Thr Ser His Leu
                2005                2010                2015    
Asp Gly Glu Ile Leu Lys Lys Glu Ser Leu Arg Ala Lys Cys Gln Gly
            2020                2025                2030        
Tyr Ala Leu Phe Val Phe Ser Leu Gly Pro Ile Trp Asp Asp Lys Glu
        2035                2040                2045            
Leu Glu Asp Leu Ala Ser His Pro Leu Asp His His Leu Val Gln Leu
    2050                2055                2060                
Gly Arg Ile His Lys Pro Asp His Ser Tyr Gly Val Lys Phe Val Lys
2065                2070                2075                2080
Ser Phe Ile Asn Ser Ile Arg Arg Ala Ile Asn Lys Tyr Pro Pro Ile
                2085                2090                2095    
Asn Leu Lys Ile Lys Cys Asn Arg Leu Asn Ser Ile Asp Pro Lys Gln
            2100                2105                2110        
Pro Pro Arg Pro Phe Arg Arg Arg Ala Gly Leu Pro Val Leu Gln Val
        2115                2120                2125            
Ser Gly Ser Leu Glu Lys Gly His Arg Gln Asp Ala Val His Val Thr
    2130                2135                2140                
Leu Ala Glu Asp Ser Ile Phe Gly Met Glu Glu Lys Tyr Glu Trp Glu
2145                2150                2155                2160
Glu Gly Ile His Ser Ala Phe Gly Gln Glu Val Ser Ser Ser Phe Val
                2165                2170                2175    
Thr Leu Pro Gln Ile His Trp Met Leu Ser Phe Ser Tyr Val Phe Glu
            2180                2185                2190        
Met Val Lys Cys Gln Gln Met Ala Gly Ala Ser Arg Asn
        2195                2200                2205


<210> 5877
<211> 389
<212> PRT
<213> Homo sapiens

<400> 5877
Met Ser Glu Tyr Thr Arg Val Ser Glu Val Glu Asn Lys Glu Leu Val
 1               5                  10                  15      
Glu Ile Ser Ser Glu Asp Asn Gly Val Val Leu Leu Ser Thr Val Thr
            20                  25                  30          
Ala Gln Phe Pro Gly Ala Cys Gly Leu His Tyr Lys Asn Pro Val Ser
        35                  40                  45              
Gln Cys Met Arg Gly Ile Gln Leu Val Glu Gly Ile Leu His Pro Asp
    50                  55                  60                  
Ala Asp Cys Gly Asn Leu Val Tyr Val Val Asn Cys Pro Lys Asp Asn
65                  70                  75                  80  
Lys Arg Lys Met Gly Glu Thr Ala Val Lys Val Lys Ser Ser Pro Glu
                85                  90                  95      
Asn Ile Leu Phe Asn Ser Val Gly Asn Tyr Leu Phe Phe Leu Leu Trp
            100                 105                 110         
Lys Gln Asp Leu Lys Glu Tyr Phe Ser Thr Ser Gly Glu Val Gln Val
        115                 120                 125             
Lys Ile Asp Ile Lys Thr Gly Lys Gly Phe Gly Phe Val His Phe Met
    130                 135                 140                 
Glu Tyr Glu Arg His Val Lys Val Met Ser Gln Thr Tyr Asp Arg Trp
145                 150                 155                 160 
Trp Tyr Asp Cys Lys Phe Pro Asn Ser Lys Gln Ser Pro Asp Glu Pro
                165                 170                 175     
Leu Arg Ser Arg Glu Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr
            180                 185                 190         
Ala Asp Glu Leu Trp Gln Phe Phe Cys Gln Tyr Lys Glu Val Val Asp
        195                 200                 205             
Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala
    210                 215                 220                 
Val Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys
225                 230                 235                 240 
Gly Leu Ser Met His Ile Ser Ser Ala Lys Pro Asn His Thr Thr Ala
                245                 250                 255     
Ile Ile Glu Arg Ser Gly Arg Phe Gly Asn Leu Ser Gly Phe Gly Asn
            260                 265                 270         
Ser Arg Gly Gly Ser Gly Leu Glu Asn Asn Arg Gly Thr Asn Thr Gly
        275                 280                 285             
Gly Met Asn Phe Gly Val Leu Ser Ile Asn Pro Ala Met Met Ala Ala
    290                 295                 300                 
Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Arg Met Ser Met Leu Ala
305                 310                 315                 320 
Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Ser Gln Gly
                325                 330                 335     
Asn Met Gln Arg Glu Pro Asn Gln Val Phe Gly Ser Arg Asn Asn Ser
            340                 345                 350         
Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Glu Ser Ala Ser
        355                 360                 365             
Gly Asn Gly Phe Asn Gly Gly Ser Gly Ser Ser Met Asp Ser Gln Ser
    370                 375                 380                 
Ser Gly Trp Glu Met
385                 


<210> 5878
<211> 331
<212> PRT
<213> Homo sapiens

<400> 5878
Met Asp Trp Val Met Lys His Asn Gly Pro Asn Asp Ala Ser Asp Gly
 1               5                  10                  15      
Thr Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile
            20                  25                  30          
Val Gln Phe Phe Gln Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu
        35                  40                  45              
Thr Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe
    50                  55                  60                  
Ala Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg
65                  70                  75                  80  
Ile Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile
                85                  90                  95      
Lys Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly
            100                 105                 110         
Pro Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly
        115                 120                 125             
Arg Gly Ser Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr
    130                 135                 140                 
Gly Tyr Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly
145                 150                 155                 160 
Met Gly Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe
                165                 170                 175     
His Gly Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr
            180                 185                 190         
Glu Asn Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val
        195                 200                 205             
His Ile Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val
    210                 215                 220                 
Glu Phe Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys
225                 230                 235                 240 
Asn Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro
                245                 250                 255     
Gly Gly Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg
            260                 265                 270         
Asp Gly Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly
        275                 280                 285             
Met Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly
    290                 295                 300                 
Gly Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly
305                 310                 315                 320 
Gly Met Ser Gly Gly Gly Trp Arg Gly Met Tyr
                325                 330     


<210> 5879
<211> 346
<212> PRT
<213> Homo sapiens

<400> 5879
Met Asp Trp Val Met Lys His Asn Gly Pro Asn Asp Ala Ser Asp Gly
 1               5                  10                  15      
Thr Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile
            20                  25                  30          
Val Gln Phe Phe Gln Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu
        35                  40                  45              
Thr Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe
    50                  55                  60                  
Ala Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg
65                  70                  75                  80  
Ile Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile
                85                  90                  95      
Lys Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly
            100                 105                 110         
Pro Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly
        115                 120                 125             
Arg Gly Ser Met Tyr Asp Arg Met Arg Arg Gly Gly Asp Gly Tyr Asp
    130                 135                 140                 
Gly Gly Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr Gly
145                 150                 155                 160 
Tyr Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly Met
                165                 170                 175     
Gly Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe His
            180                 185                 190         
Gly Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr Glu
        195                 200                 205             
Asn Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val His
    210                 215                 220                 
Ile Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val Glu
225                 230                 235                 240 
Phe Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Asn
                245                 250                 255     
Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro Gly
            260                 265                 270         
Gly Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg Asp
        275                 280                 285             
Gly Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly Met
    290                 295                 300                 
Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly Gly
305                 310                 315                 320 
Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly Gly
                325                 330                 335     
Met Ser Gly Gly Gly Trp Arg Gly Met Tyr
            340                 345     


<210> 5880
<211> 297
<212> PRT
<213> Homo sapiens

<400> 5880
Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala
 1               5                  10                  15      
Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg Ile
            20                  25                  30          
Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile Lys
        35                  40                  45              
Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly Pro
    50                  55                  60                  
Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly Arg
65                  70                  75                  80  
Gly Ser Met Tyr Asp Arg Met Arg Arg Gly Gly Asp Gly Tyr Asp Gly
                85                  90                  95      
Gly Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr Gly Tyr
            100                 105                 110         
Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly Met Gly
        115                 120                 125             
Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe His Gly
    130                 135                 140                 
Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr Glu Asn
145                 150                 155                 160 
Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val His Ile
                165                 170                 175     
Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val Glu Phe
            180                 185                 190         
Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Asn Asn
        195                 200                 205             
Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro Gly Gly
    210                 215                 220                 
Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg Asp Gly
225                 230                 235                 240 
Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly Met Gly
                245                 250                 255     
Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly Gly Tyr
            260                 265                 270         
Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly Gly Met
        275                 280                 285             
Ser Gly Gly Gly Trp Arg Gly Met Tyr
    290                 295         


<210> 5881
<211> 215
<212> PRT
<213> Homo sapiens

<400> 5881
Met Tyr Asp Arg Met Arg Arg Gly Gly Asp Gly Tyr Asp Gly Gly Tyr
 1               5                  10                  15      
Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr Gly Tyr Gly Asn
            20                  25                  30          
Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly Met Gly Gly His
        35                  40                  45              
Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe His Gly Gly His
    50                  55                  60                  
Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr Glu Asn Asp Ile
65                  70                  75                  80  
Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val His Ile Asp Ile
                85                  90                  95      
Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val Glu Phe Val Thr
            100                 105                 110         
His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Asn Asn Met Gln
        115                 120                 125             
His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro Gly Gly Gly Ser
    130                 135                 140                 
Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg Asp Gly Met Asp
145                 150                 155                 160 
Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly Met Gly Asn Asn
                165                 170                 175     
Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly Gly Tyr Gly Arg
            180                 185                 190         
Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly Gly Met Ser Gly
        195                 200                 205             
Gly Gly Trp Arg Gly Met Tyr
    210                 215 


<210> 5882
<211> 724
<212> PRT
<213> Homo sapiens

<400> 5882
Gly Glu Lys Gly Gly Met Lys Pro Pro Ala His Trp Thr Gly Gly Leu
 1               5                  10                  15      
Gln Pro Glu Leu Gln Gly Ser Pro Ala Gly Trp Asp Ser Thr Glu Gly
            20                  25                  30          
Trp Thr Trp Gly Asp Gly Glu His Gly Leu Gly Ala Ala Ala Met Pro
        35                  40                  45              
Thr Trp Gly Ala Arg Pro Ala Ser Pro Asp Arg Phe Ala Val Ser Ala
    50                  55                  60                  
Glu Ala Glu Asn Lys Val Arg Glu Gln Gln Pro His Val Glu Arg Ile
65                  70                  75                  80  
Phe Ser Val Gly Val Ser Val Leu Pro Lys Asp Cys Pro Asp Asn Pro
                85                  90                  95      
His Ile Trp Leu Gln Leu Glu Gly Pro Lys Glu Asn Ala Ser Arg Ala
            100                 105                 110         
Lys Glu Tyr Leu Lys Gly Leu Cys Ser Pro Glu Leu Gln Asp Glu Ile
        115                 120                 125             
His Tyr Pro Pro Lys Leu His Cys Ile Phe Leu Gly Ala Gln Gly Phe
    130                 135                 140                 
Phe Leu Asp Cys Leu Ala Trp Ser Thr Ser Ala His Leu Val Pro Arg
145                 150                 155                 160 
Ala Pro Gly Ser Leu Met Ile Ser Gly Leu Thr Glu Ala Phe Val Met
                165                 170                 175     
Ala Gln Ser Arg Val Glu Glu Leu Ala Glu Arg Leu Ser Trp Asp Phe
            180                 185                 190         
Thr Pro Gly Pro Ser Ser Gly Ala Ser Gln Cys Thr Gly Val Leu Arg
        195                 200                 205             
Asp Phe Ser Ala Leu Leu Gln Ser Pro Gly Asp Ala His Arg Glu Ala
    210                 215                 220                 
Leu Leu Gln Leu Pro Leu Ala Val Gln Glu Glu Leu Leu Ser Leu Val
225                 230                 235                 240 
Gln Glu Ala Ser Ser Gly Gln Gly Pro Gly Ala Leu Ala Ser Trp Glu
                245                 250                 255     
Gly Arg Ser Ser Ala Leu Leu Gly Ala Gln Cys Gln Gly Val Arg Ala
            260                 265                 270         
Pro Pro Ser Asp Gly Arg Glu Ser Leu Asp Thr Gly Ser Met Gly Pro
        275                 280                 285             
Gly Asp Cys Arg Gly Ala Arg Gly Asp Thr Tyr Ala Val Glu Lys Glu
    290                 295                 300                 
Gly Gly Thr Gln Gly Gly Pro Arg Glu Met Asp Leu Gly Trp Lys Glu
305                 310                 315                 320 
Leu Pro Gly Glu Glu Ala Trp Glu Arg Glu Val Ala Leu Arg Pro Gln
                325                 330                 335     
Ser Val Gly Gly Gly Ala Arg Glu Ser Ala Pro Leu Lys Gly Lys Ala
            340                 345                 350         
Leu Gly Lys Glu Glu Ile Ala Leu Gly Gly Gly Gly Phe Cys Val His
        355                 360                 365             
Arg Glu Pro Pro Gly Ala His Gly Ser Cys His Arg Ala Ala Gln Ser
    370                 375                 380                 
Arg Gly Ala Ser Leu Leu Gln Arg Leu His Asn Gly Asn Ala Ser Pro
385                 390                 395                 400 
Pro Arg Val Pro Ser Pro Pro Pro Ala Pro Glu Pro Pro Trp His Cys
                405                 410                 415     
Gly Asp Arg Gly Asp Cys Gly Asp Arg Gly Asp Val Gly Asp Arg Gly
            420                 425                 430         
Asp Lys Gln Gln Gly Met Ala Arg Gly Arg Gly Pro Gln Trp Lys Arg
        435                 440                 445             
Gly Ala Arg Gly Gly Asn Leu Val Thr Gly Thr Gln Arg Phe Lys Glu
    450                 455                 460                 
Ala Leu Gln Asp Pro Phe Thr Leu Cys Leu Ala Asn Val Pro Gly Gln
465                 470                 475                 480 
Pro Asp Leu Arg His Ile Val Ile Asp Gly Ser Asn Val Ala Met Val
                485                 490                 495     
His Gly Leu Gln His Tyr Phe Ser Ser Arg Gly Ile Ala Ile Ala Val
            500                 505                 510         
Gln Tyr Phe Trp Asp Arg Gly His Arg Asp Ile Thr Val Phe Val Pro
        515                 520                 525             
Gln Trp Arg Phe Ser Lys Asp Ala Lys Val Arg Glu Ser His Phe Leu
    530                 535                 540                 
Gln Lys Leu Tyr Ser Leu Ser Leu Leu Ser Leu Thr Pro Ser Arg Val
545                 550                 555                 560 
Met Asp Gly Lys Arg Ile Ser Ser Tyr Asp Asp Arg Phe Met Val Lys
                565                 570                 575     
Leu Ala Glu Glu Thr Asp Gly Ile Ile Val Ser Asn Asp Gln Phe Arg
            580                 585                 590         
Asp Leu Ala Glu Glu Ser Glu Lys Trp Met Ala Ile Ile Arg Glu Arg
        595                 600                 605             
Leu Leu Pro Phe Thr Phe Val Gly Asn Leu Phe Met Val Pro Asp Asp
    610                 615                 620                 
Pro Leu Gly Arg Asn Gly Pro Thr Leu Asp Glu Phe Leu Lys Lys Pro
625                 630                 635                 640 
Ala Arg Thr Gln Gly Ser Ser Lys Ala Gln His Pro Ser Arg Gly Phe
                645                 650                 655     
Ala Glu His Gly Lys Gln Gln Gln Gly Arg Glu Glu Glu Lys Gly Ser
            660                 665                 670         
Gly Gly Ile Arg Lys Thr Arg Glu Thr Glu Arg Leu Arg Arg Gln Leu
        675                 680                 685             
Leu Glu Val Phe Trp Gly Gln Asp His Lys Val Asp Phe Ile Leu Gln
    690                 695                 700                 
Arg Glu Pro Tyr Cys Arg Asp Ile Asn Gln Leu Ser Glu Ala Leu Leu
705                 710                 715                 720 
Ser Leu Asn Phe
                


<210> 5883
<211> 641
<212> PRT
<213> Homo sapiens

<400> 5883
Met Gly Pro Pro Leu Lys Leu Phe Lys Asn Gln Lys Tyr Gln Glu Leu
 1               5                  10                  15      
Lys Gln Glu Cys Ile Lys Asp Ser Arg Leu Phe Cys Asp Pro Thr Phe
            20                  25                  30          
Leu Pro Glu Asn Asp Ser Leu Phe Tyr Asn Arg Leu Leu Pro Gly Lys
        35                  40                  45              
Val Val Trp Lys Arg Pro Gln Asp Ile Cys Asp Asp Pro His Leu Ile
    50                  55                  60                  
Val Gly Asn Ile Ser Asn His Gln Leu Thr Gln Gly Arg Leu Gly His
65                  70                  75                  80  
Lys Pro Met Val Ser Ala Phe Ser Cys Leu Ala Val Gln Glu Ser His
                85                  90                  95      
Trp Thr Lys Thr Ile Pro Asn His Lys Glu Gln Glu Trp Asp Pro Gln
            100                 105                 110         
Lys Thr Glu Lys Tyr Ala Gly Ile Phe His Phe Arg Phe Trp His Phe
        115                 120                 125             
Gly Glu Trp Thr Glu Val Val Ile Asp Asp Leu Leu Pro Thr Ile Asn
    130                 135                 140                 
Gly Asp Leu Val Phe Ser Phe Ser Thr Ser Met Asn Glu Phe Trp Asn
145                 150                 155                 160 
Ala Leu Leu Glu Lys Ala Tyr Ala Lys Leu Leu Gly Cys Tyr Glu Ala
                165                 170                 175     
Leu Asp Gly Leu Thr Ile Thr Asp Ile Ile Val Asp Phe Thr Gly Thr
            180                 185                 190         
Leu Ala Glu Thr Val Asp Met Gln Lys Gly Arg Tyr Thr Glu Leu Val
        195                 200                 205             
Glu Glu Lys Tyr Lys Leu Phe Gly Glu Leu Tyr Lys Thr Phe Thr Lys
    210                 215                 220                 
Gly Gly Leu Ile Cys Cys Ser Ile Glu Ser Pro Asn Gln Glu Glu Gln
225                 230                 235                 240 
Glu Val Glu Thr Asp Trp Gly Leu Leu Lys Gly His Thr Tyr Thr Met
                245                 250                 255     
Thr Asp Ile Arg Lys Ile Arg Leu Gly Glu Arg Leu Val Glu Val Phe
            260                 265                 270         
Ser Ala Glu Lys Val Tyr Met Val Arg Leu Arg Asn Pro Leu Gly Arg
        275                 280                 285             
Gln Glu Trp Ser Gly Pro Trp Ser Glu Ile Ser Glu Glu Trp Gln Gln
    290                 295                 300                 
Leu Thr Ala Ser Asp Arg Lys Asn Leu Gly Leu Val Met Ser Asp Asp
305                 310                 315                 320 
Gly Glu Phe Trp Met Ser Leu Glu Asp Phe Cys Arg Asn Phe His Lys
                325                 330                 335     
Leu Asn Val Cys Arg Asn Val Asn Asn Pro Ile Phe Gly Arg Lys Glu
            340                 345                 350         
Leu Glu Ser Val Leu Gly Cys Trp Thr Val Asp Asp Asp Pro Leu Met
        355                 360                 365             
Asn Arg Ser Gly Gly Cys Tyr Asn Asn Arg Asp Thr Phe Leu Gln Asn
    370                 375                 380                 
Pro Gln Tyr Ile Phe Thr Val Pro Glu Asp Gly His Lys Val Ile Met
385                 390                 395                 400 
Ser Leu Gln Gln Lys Asp Leu Arg Thr Tyr Arg Arg Met Gly Arg Pro
                405                 410                 415     
Asp Asn Tyr Ile Ile Gly Phe Glu Leu Phe Lys Val Glu Met Asn Arg
            420                 425                 430         
Lys Phe Arg Leu His His Leu Tyr Ile Gln Glu Arg Ala Gly Thr Ser
        435                 440                 445             
Thr Tyr Ile Asp Thr Arg Thr Val Phe Leu Ser Lys Tyr Leu Lys Lys
    450                 455                 460                 
Gly Asn Tyr Val Leu Val Pro Thr Met Phe Gln His Gly Arg Thr Ser
465                 470                 475                 480 
Glu Phe Leu Leu Arg Ile Phe Ser Glu Val Pro Val Gln Leu Arg Glu
                485                 490                 495     
Leu Thr Leu Asp Met Pro Lys Met Ser Cys Trp Asn Leu Ala Arg Gly
            500                 505                 510         
Tyr Pro Lys Val Val Thr Gln Ile Thr Val His Ser Ala Glu Asp Leu
        515                 520                 525             
Glu Lys Lys Tyr Ala Asn Glu Thr Val Asn Pro Tyr Leu Val Ile Lys
    530                 535                 540                 
Cys Gly Lys Glu Glu Val Arg Ser Pro Val Gln Lys Asn Thr Val His
545                 550                 555                 560 
Ala Ile Phe Asp Thr Gln Ala Ile Phe Tyr Arg Arg Thr Thr Asp Ile
                565                 570                 575     
Pro Ile Ile Val Gln Val Trp Asn Ser Arg Lys Phe Cys Asp Gln Phe
            580                 585                 590         
Leu Gly Gln Val Thr Leu Asp Ala Asp Pro Ser Asp Cys Arg Asp Leu
        595                 600                 605             
Lys Ser Leu Tyr Leu Arg Lys Lys Gly Gly Pro Thr Ala Lys Val Lys
    610                 615                 620                 
Gln Gly His Ile Ser Phe Lys Val Ile Ser Ser Asp Asp Leu Thr Glu
625                 630                 635                 640 
Leu
    


<210> 5884
<211> 974
<212> PRT
<213> Homo sapiens

<400> 5884
Met Ala Ala Glu Ala Ala Gly Gly Lys Tyr Arg Ser Thr Val Ser Lys
 1               5                  10                  15      
Ser Lys Asp Pro Ser Gly Leu Leu Ile Ser Val Ile Arg Thr Leu Ser
            20                  25                  30          
Thr Ser Asp Asp Val Glu Asp Arg Glu Asn Glu Lys Gly Arg Leu Glu
        35                  40                  45              
Glu Ala Tyr Glu Lys Cys Asp Arg Asp Leu Asp Glu Leu Ile Val Gln
    50                  55                  60                  
His Tyr Thr Glu Leu Thr Thr Ala Ile Arg Thr Tyr Gln Ser Ile Thr
65                  70                  75                  80  
Glu Arg Ile Thr Asn Ser Arg Asn Lys Ile Lys Gln Val Lys Glu Asn
                85                  90                  95      
Leu Leu Ser Cys Lys Met Leu Leu His Cys Lys Arg Asp Glu Leu Arg
            100                 105                 110         
Lys Leu Trp Ile Glu Gly Ile Glu His Lys His Val Leu Asn Leu Leu
        115                 120                 125             
Asp Glu Ile Glu Asn Ile Lys Gln Val Pro Gln Lys Leu Glu Gln Cys
    130                 135                 140                 
Met Ala Ser Lys His Tyr Leu Ser Ala Thr Asp Met Leu Val Ser Ala
145                 150                 155                 160 
Val Glu Ser Leu Glu Gly Pro Leu Leu Gln Val Glu Gly Leu Ser Asp
                165                 170                 175     
Leu Arg Leu Glu Leu His Ser Lys Lys Met Asn Leu His Leu Val Leu
            180                 185                 190         
Ile Asp Glu Leu His Arg His Leu Tyr Ile Lys Ser Thr Ser Arg Val
        195                 200                 205             
Val Gln Arg Asn Lys Glu Lys Gly Lys Ile Ser Ser Leu Val Lys Asp
    210                 215                 220                 
Ala Ser Val Pro Leu Ile Asp Val Thr Asn Leu Pro Thr Pro Arg Lys
225                 230                 235                 240 
Phe Leu Asp Thr Ser His Tyr Ser Thr Ala Gly Ser Ser Ser Val Arg
                245                 250                 255     
Glu Ile Asn Leu Gln Asp Ile Lys Glu Asp Leu Glu Leu Asp Pro Glu
            260                 265                 270         
Glu Asn Ser Thr Leu Phe Met Gly Ile Leu Ile Lys Gly Leu Ala Lys
        275                 280                 285             
Leu Lys Lys Ile Pro Glu Thr Val Lys Ala Ile Ile Glu Arg Leu Glu
    290                 295                 300                 
Gln Glu Leu Lys Gln Ile Val Lys Arg Ser Thr Thr Gln Val Ala Asp
305                 310                 315                 320 
Ser Gly Tyr Gln Arg Gly Glu Asn Val Thr Val Glu Asn Gln Pro Arg
                325                 330                 335     
Leu Leu Leu Glu Leu Leu Glu Leu Leu Phe Asp Lys Phe Asn Ala Val
            340                 345                 350         
Ala Ala Ala His Ser Val Val Leu Gly Tyr Leu Gln Asp Thr Val Val
        355                 360                 365             
Thr Pro Leu Thr Gln Gln Glu Asp Ile Lys Leu Tyr Asp Met Ala Asp
    370                 375                 380                 
Val Trp Val Lys Ile Gln Asp Val Leu Gln Met Leu Leu Thr Glu Tyr
385                 390                 395                 400 
Leu Asp Met Lys Asn Thr Arg Thr Ala Ser Glu Pro Ser Ala Gln Leu
                405                 410                 415     
Ser Tyr Ala Ser Thr Gly Arg Glu Phe Ala Ala Phe Phe Ala Lys Lys
            420                 425                 430         
Lys Pro Gln Arg Pro Lys Asn Ser Leu Phe Lys Phe Glu Ser Ser Ser
        435                 440                 445             
His Ala Ile Ser Met Ser Ala Tyr Leu Arg Glu Gln Arg Arg Glu Leu
    450                 455                 460                 
Tyr Ser Arg Ser Gly Glu Leu Gln Gly Gly Pro Asp Asp Asn Leu Ile
465                 470                 475                 480 
Glu Gly Gly Gly Thr Lys Phe Val Cys Lys Pro Gly Ala Arg Asn Ile
                485                 490                 495     
Thr Val Ile Phe His Pro Leu Leu Arg Phe Ile Gln Glu Ile Glu His
            500                 505                 510         
Ala Leu Gly Leu Gly Pro Ala Lys Gln Cys Pro Leu Arg Glu Phe Leu
        515                 520                 525             
Thr Val Tyr Ile Lys Asn Ile Phe Leu Asn Gln Val Leu Ala Glu Ile
    530                 535                 540                 
Asn Lys Glu Ile Glu Gly Val Thr Lys Thr Ser Asp Pro Leu Lys Ile
545                 550                 555                 560 
Leu Ala Asn Ala Asp Thr Met Lys Val Leu Gly Val Gln Arg Pro Leu
                565                 570                 575     
Leu Gln Ser Thr Ile Ile Val Glu Lys Thr Val Gln Asp Leu Leu Asn
            580                 585                 590         
Leu Met His Asp Leu Ser Ala Tyr Ser Asp Gln Phe Leu Asn Met Val
        595                 600                 605             
Cys Val Lys Leu Gln Glu Tyr Lys Asp Thr Cys Thr Ala Ala Tyr Arg
    610                 615                 620                 
Gly Ile Val Gln Ser Glu Glu Lys Leu Val Ile Ser Ala Ser Trp Ala
625                 630                 635                 640 
Lys Asp Asp Asp Ile Ser Arg Leu Leu Lys Ser Leu Pro Asn Trp Met
                645                 650                 655     
Asn Met Ala Gln Pro Lys Gln Leu Arg Pro Lys Arg Glu Glu Glu Glu
            660                 665                 670         
Asp Phe Ile Arg Ala Ala Phe Gly Lys Glu Ser Glu Val Leu Ile Gly
        675                 680                 685             
Asn Leu Gly Asp Lys Leu Ile Pro Pro Gln Asp Ile Leu Arg Asp Val
    690                 695                 700                 
Ser Asp Leu Lys Ala Leu Ala Asn Met His Glu Ser Leu Glu Trp Leu
705                 710                 715                 720 
Ala Ser Arg Thr Lys Ser Ala Phe Ser Asn Leu Ser Thr Ser Gln Met
                725                 730                 735     
Leu Ser Pro Ala Gln Asp Ser His Thr Asn Thr Asp Leu Pro Pro Val
            740                 745                 750         
Ser Glu Gln Ile Met Gln Thr Leu Ser Glu Leu Ala Lys Ser Phe Gln
        755                 760                 765             
Asp Met Ala Asp Arg Cys Leu Leu Val Leu His Leu Glu Val Arg Val
    770                 775                 780                 
His Cys Phe His Tyr Leu Ile Pro Leu Ala Lys Glu Gly Asn Tyr Ala
785                 790                 795                 800 
Ile Val Ala Asn Val Glu Ser Met Asp Tyr Asp Pro Leu Val Val Lys
                805                 810                 815     
Leu Asn Lys Asp Ile Ser Ala Ile Glu Glu Ala Met Ser Ala Ser Leu
            820                 825                 830         
Gln Gln His Lys Phe Gln Tyr Ile Phe Glu Gly Leu Gly His Leu Ile
        835                 840                 845             
Ser Cys Ile Leu Ile Asn Gly Ala Gln Tyr Phe Arg Arg Ile Ser Glu
    850                 855                 860                 
Ser Gly Ile Lys Lys Met Cys Arg Asn Ile Phe Val Leu Gln Gln Asn
865                 870                 875                 880 
Leu Thr Asn Ile Thr Met Ser Arg Glu Ala Asp Leu Asp Phe Ala Arg
                885                 890                 895     
Gln Tyr Tyr Glu Met Leu Tyr Asn Thr Ala Asp Glu Leu Leu Asn Leu
            900                 905                 910         
Val Val Asp Gln Gly Val Lys Tyr Thr Glu Leu Glu Tyr Ile His Ala
        915                 920                 925             
Leu Thr Leu Leu His Arg Ser Gln Thr Gly Val Gly Glu Leu Thr Thr
    930                 935                 940                 
Gln Asn Thr Arg Leu Gln Arg Leu Lys Glu Ile Ile Cys Glu Gln Ala
945                 950                 955                 960 
Ala Ile Lys Gln Ala Thr Lys Asp Lys Lys Ile Thr Thr Val
                965                 970                 


<210> 5885
<211> 476
<212> PRT
<213> Homo sapiens

<400> 5885
Met Asp Glu Ala Gly Ser Ser Ala Ser Gly Gly Gly Phe Arg Pro Gly
 1               5                  10                  15      
Val Asp Ser Leu Asp Glu Pro Pro Asn Ser Arg Ile Phe Leu Val Ile
            20                  25                  30          
Ser Lys Tyr Thr Pro Glu Ser Val Leu Arg Glu Arg Phe Ser Pro Phe
        35                  40                  45              
Gly Asp Ile Gln Asp Ile Trp Val Val Arg Asp Lys His Thr Lys Glu
    50                  55                  60                  
Ser Lys Gly Ile Ala Phe Val Lys Phe Ala Arg Ser Ser Gln Ala Cys
65                  70                  75                  80  
Arg Ala Met Glu Glu Met His Gly Gln Cys Leu Gly Pro Asn Asp Thr
                85                  90                  95      
Lys Pro Ile Lys Val Phe Ile Ala Gln Ser Arg Ser Ser Gly Ser His
            100                 105                 110         
Arg Asp Val Glu Asp Glu Glu Leu Thr Arg Ile Phe Val Met Ile Pro
        115                 120                 125             
Lys Ser Tyr Thr Glu Glu Asp Leu Arg Glu Lys Phe Lys Val Tyr Gly
    130                 135                 140                 
Asp Ile Glu Tyr Cys Ser Ile Ile Lys Asn Lys Val Thr Gly Glu Ser
145                 150                 155                 160 
Lys Gly Leu Gly Tyr Val Arg Tyr Leu Lys Pro Ser Gln Ala Ala Gln
                165                 170                 175     
Ala Ile Glu Asn Cys Asp Arg Ser Phe Arg Ala Ile Leu Ala Glu Pro
            180                 185                 190         
Lys Asn Lys Ala Ser Glu Ser Ser Glu Gln Asp Tyr Tyr Ser Asn Met
        195                 200                 205             
Arg Gln Glu Ala Leu Gly His Glu Pro Arg Val Asn Met Phe Pro Phe
    210                 215                 220                 
Val Gly Glu Gln Gln Ser Glu Phe Ser Ser Phe Asp Lys Asn Asp Ser
225                 230                 235                 240 
Arg Gly Gln Glu Ala Ile Ser Lys Arg Leu Ser Val Val Ser Arg Val
                245                 250                 255     
Pro Phe Thr Glu Glu Gln Leu Phe Ser Ile Phe Asp Ile Val Pro Gly
            260                 265                 270         
Leu Glu Tyr Cys Glu Val Gln Arg Asp Pro Tyr Ser Asn Tyr Gly His
        275                 280                 285             
Gly Val Val Gln Tyr Phe Asn Val Ala Ser Ala Ile Tyr Ala Lys Tyr
    290                 295                 300                 
Lys Leu His Gly Phe Gln Tyr Pro Pro Gly Asn Arg Ile Gly Val Ser
305                 310                 315                 320 
Phe Ile Asp Asp Gly Ser Asn Ala Thr Asp Leu Leu Arg Lys Met Ala
                325                 330                 335     
Thr Gln Met Val Ala Ala Gln Leu Ala Ser Met Val Trp Asn Asn Pro
            340                 345                 350         
Ser Gln Gln Gln Phe Met Gln Phe Gly Gly Ser Ser Gly Ser Gln Leu
        355                 360                 365             
Pro Gln Ile Gln Thr Asp Val Val Leu Pro Ser Cys Lys Lys Lys Ala
    370                 375                 380                 
Pro Ala Glu Thr Pro Val Lys Glu Arg Leu Phe Ile Val Phe Asn Pro
385                 390                 395                 400 
His Pro Leu Pro Leu Asp Val Leu Glu Asp Ile Phe Cys Arg Phe Gly
                405                 410                 415     
Asn Leu Ile Glu Val Tyr Leu Val Ser Gly Lys Asn Val Gly Tyr Ala
            420                 425                 430         
Lys Tyr Ala Asp Arg Ile Ser Ala Asn Asp Ala Ile Ala Thr Leu His
        435                 440                 445             
Gly Lys Ile Leu Asn Gly Val Arg Leu Lys Val Met Leu Ala Asp Ser
    450                 455                 460                 
Pro Arg Glu Glu Ser Asn Lys Arg Gln Arg Thr Tyr
465                 470                 475     


<210> 5886
<211> 1719
<212> PRT
<213> Homo sapiens

<400> 5886
Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp
 1               5                  10                  15      
Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu
            20                  25                  30          
Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg
        35                  40                  45              
Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr
    50                  55                  60                  
Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu
65                  70                  75                  80  
Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu
                85                  90                  95      
Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu
            100                 105                 110         
Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val
        115                 120                 125             
Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe
    130                 135                 140                 
Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly
145                 150                 155                 160 
Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp
                165                 170                 175     
Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val
            180                 185                 190         
His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu
        195                 200                 205             
Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu
    210                 215                 220                 
Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr
225                 230                 235                 240 
Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys
                245                 250                 255     
Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met
            260                 265                 270         
Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val
        275                 280                 285             
Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro
    290                 295                 300                 
Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg
305                 310                 315                 320 
Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp
                325                 330                 335     
Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg
            340                 345                 350         
Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr
        355                 360                 365             
Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met
    370                 375                 380                 
Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val
385                 390                 395                 400 
Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu
                405                 410                 415     
Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln
            420                 425                 430         
Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile
        435                 440                 445             
Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu
    450                 455                 460                 
Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro
465                 470                 475                 480 
Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile
                485                 490                 495     
Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln
            500                 505                 510         
Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg
        515                 520                 525             
Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg
    530                 535                 540                 
Glu Asp Leu Asn Lys Glu Leu Val Gln Ala Ser Glu Arg Leu Lys Asn
545                 550                 555                 560 
Gln Ser Lys Glu Leu Lys Asp Ala His Cys Gln Arg Lys Leu Ala Met
                565                 570                 575     
Gln Glu Phe Met Glu Ile Asn Glu Arg Leu Thr Glu Leu His Thr Gln
            580                 585                 590         
Lys Gln Lys Leu Ala Arg His Val Arg Asp Lys Glu Glu Glu Val Asp
        595                 600                 605             
Leu Val Met Gln Lys Val Glu Ser Leu Arg Gln Glu Leu Arg Arg Thr
    610                 615                 620                 
Glu Arg Ala Lys Lys Glu Leu Glu Val His Thr Glu Ala Leu Ala Ala
625                 630                 635                 640 
Glu Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser
                645                 650                 655     
Lys Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser
            660                 665                 670         
Tyr Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys
        675                 680                 685             
Leu Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu
    690                 695                 700                 
Ser Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys
705                 710                 715                 720 
Glu Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile
                725                 730                 735     
Met Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser
            740                 745                 750         
Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu
        755                 760                 765             
Lys Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp
    770                 775                 780                 
Lys Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu
785                 790                 795                 800 
Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His
                805                 810                 815     
Trp Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys
            820                 825                 830         
Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu
        835                 840                 845             
Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met
    850                 855                 860                 
Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu
865                 870                 875                 880 
Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile
                885                 890                 895     
Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys
            900                 905                 910         
Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile
        915                 920                 925             
Glu Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile
    930                 935                 940                 
Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro
945                 950                 955                 960 
Thr Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser
                965                 970                 975     
Val His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly
            980                 985                 990         
Phe Pro Pro Lys Arg Lys Thr His Gln Phe Phe Val Lys Ser Phe Thr
        995                 1000                1005            
Thr Pro Thr Lys Cys His Gln Cys Thr Ser Leu Met Val Gly Leu Ile
    1010                1015                1020                
Arg Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Thr
1025                1030                1035                1040
Cys Val Asn Lys Ala Pro Thr Thr Cys Pro Val Pro Pro Glu Gln Thr
                1045                1050                1055    
Lys Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Thr Ala Tyr
            1060                1065                1070        
Glu Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly Trp
        1075                1080                1085            
Gln Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr Asp
    1090                1095                1100                
Ile Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln Val
1105                1110                1115                1120
Ile Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala Ser
                1125                1130                1135    
Asp Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg Val
            1140                1145                1150        
Thr Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu Met
        1155                1160                1165            
Leu Ala Asp Thr Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu Ser
    1170                1175                1180                
Glu Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser Val
1185                1190                1195                1200
Tyr Val Pro Lys Glu Ala Tyr Asp Ser Thr Leu Pro Leu Ile Lys Thr
                1205                1210                1215    
Thr Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly Asn
            1220                1225                1230        
Glu Glu Gly Leu Phe Val Val His Val Thr Lys Asp Glu Ile Ile Arg
        1235                1240                1245            
Val Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn Asp
    1250                1255                1260                
Gln Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu Phe
1265                1270                1275                1280
Pro Met Ser Ala Leu Asp Gly Arg Glu Thr Asp Phe Tyr Lys Leu Ser
                1285                1290                1295    
Glu Thr Lys Gly Cys Gln Thr Val Thr Ser Gly Lys Val Arg His Gly
            1300                1305                1310        
Ala Leu Thr Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys Tyr
        1315                1320                1325            
Glu Leu Phe Gln Ser Lys Thr Arg His Arg Lys Phe Lys Glu Ile Gln
    1330                1335                1340                
Val Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu Cys
1345                1350                1355                1360
Val Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu Gly
                1365                1370                1375    
Asn Pro Tyr Ser Met Leu His Ser Asn Asp His Thr Leu Ser Phe Ile
            1380                1385                1390        
Ala His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser Lys
        1395                1400                1405            
Glu Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Thr Asp Cys Gln
    1410                1415                1420                
Gly Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro Ser
1425                1430                1435                1440
Ser Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn Ala
                1445                1450                1455    
Val Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Thr Leu Pro
            1460                1465                1470        
Leu Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu Leu
        1475                1480                1485            
Gly Leu Glu Thr Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala Glu
    1490                1495                1500                
Gly Asp Glu Leu Val Val Pro Glu Thr Ser Asp Asn Ser Arg Lys Gln
1505                1510                1515                1520
Met Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val Pro
                1525                1530                1535    
Glu Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu
            1540                1545                1550        
Met Arg Asn Lys Leu Ile Ser Asn Pro Thr Asn Phe Asn His Ile Ala
        1555                1560                1565            
His Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro Met
    1570                1575                1580                
Asn Pro Arg Pro Gln Glu Ser Arg Thr Val Phe Ser Gly Ser Val Ser
1585                1590                1595                1600
Ile Pro Ser Ile Thr Lys Ser Arg Pro Glu Pro Gly Arg Ser Met Ser
                1605                1610                1615    
Ala Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser Ala
            1620                1625                1630        
Leu Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln Pro
        1635                1640                1645            
Met Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp Gln
    1650                1655                1660                
Gly Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp Ser
1665                1670                1675                1680
Pro Arg His Ser Thr Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro Pro
                1685                1690                1695    
Ser Pro Val Ser Pro Arg Lys Thr Lys Ser Leu Ser Leu Glu Ser Thr
            1700                1705                1710        
Asp Arg Gly Ser Trp Asp Pro
        1715                


<210> 5887
<211> 1638
<212> PRT
<213> Homo sapiens

<400> 5887
Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp
 1               5                  10                  15      
Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu
            20                  25                  30          
Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg
        35                  40                  45              
Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr
    50                  55                  60                  
Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu
65                  70                  75                  80  
Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu
                85                  90                  95      
Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu
            100                 105                 110         
Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val
        115                 120                 125             
Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe
    130                 135                 140                 
Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly
145                 150                 155                 160 
Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp
                165                 170                 175     
Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val
            180                 185                 190         
His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu
        195                 200                 205             
Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu
    210                 215                 220                 
Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr
225                 230                 235                 240 
Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys
                245                 250                 255     
Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met
            260                 265                 270         
Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val
        275                 280                 285             
Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro
    290                 295                 300                 
Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Pro Ile Arg Arg
305                 310                 315                 320 
Leu Ile Cys Gly Arg Glu His Arg Leu Gly Gln Ser Gly Ile Glu Asp
                325                 330                 335     
Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg
            340                 345                 350         
Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr
        355                 360                 365             
Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met
    370                 375                 380                 
Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val
385                 390                 395                 400 
Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu
                405                 410                 415     
Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln
            420                 425                 430         
Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile
        435                 440                 445             
Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu
    450                 455                 460                 
Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro
465                 470                 475                 480 
Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Val Ile
                485                 490                 495     
Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln
            500                 505                 510         
Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg
        515                 520                 525             
Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg
    530                 535                 540                 
Glu Asp Leu Asn Lys Leu Glu Val His Thr Glu Ala Leu Ala Ala Glu
545                 550                 555                 560 
Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser Lys
                565                 570                 575     
Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser Tyr
            580                 585                 590         
Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys Leu
        595                 600                 605             
Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu Ser
    610                 615                 620                 
Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys Glu
625                 630                 635                 640 
Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile Met
                645                 650                 655     
Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser Glu
            660                 665                 670         
Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu Lys
        675                 680                 685             
Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp Lys
    690                 695                 700                 
Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu Glu
705                 710                 715                 720 
Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His Trp
                725                 730                 735     
Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp
            740                 745                 750         
Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu
        755                 760                 765             
Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met Pro
    770                 775                 780                 
Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu Glu
785                 790                 795                 800 
Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile Gln
                805                 810                 815     
Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys Lys
            820                 825                 830         
Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile Glu
        835                 840                 845             
Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile Glu
    850                 855                 860                 
His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro Thr
865                 870                 875                 880 
Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser Val
                885                 890                 895     
His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly Phe
            900                 905                 910         
Pro Pro Lys Arg Lys Thr His Gln Phe Phe Val Lys Ser Phe Thr Thr
        915                 920                 925             
Pro Thr Lys Cys His Gln Cys Thr Ser Leu Met Val Gly Leu Ile Arg
    930                 935                 940                 
Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Thr Cys
945                 950                 955                 960 
Val Asn Lys Ala Pro Thr Thr Cys Pro Val Pro Pro Glu Gln Thr Lys
                965                 970                 975     
Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Thr Ala Tyr Glu
            980                 985                 990         
Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly Trp Gln
        995                 1000                1005            
Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr Asp Ile
    1010                1015                1020                
Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln Val Ile
1025                1030                1035                1040
Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala Ser Asp
                1045                1050                1055    
Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg Val Thr
            1060                1065                1070        
Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu Met Leu
        1075                1080                1085            
Ala Asp Thr Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu Ser Glu
    1090                1095                1100                
Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser Val Tyr
1105                1110                1115                1120
Val Pro Lys Glu Ala Tyr Asp Ser Thr Leu Pro Leu Ile Lys Thr Thr
                1125                1130                1135    
Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly Asn Glu
            1140                1145                1150        
Glu Gly Leu Phe Val Val His Val Thr Lys Asp Glu Ile Ile Arg Val
        1155                1160                1165            
Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn Asp Gln
    1170                1175                1180                
Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu Phe Pro
1185                1190                1195                1200
Met Ser Ala Leu Asp Gly Arg Glu Thr Asp Phe Tyr Lys Leu Ser Glu
                1205                1210                1215    
Thr Lys Gly Cys Gln Thr Val Thr Ser Gly Lys Val Arg His Gly Ala
            1220                1225                1230        
Leu Thr Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys Tyr Glu
        1235                1240                1245            
Leu Phe Gln Ser Lys Thr Arg His Arg Lys Phe Lys Glu Ile Gln Val
    1250                1255                1260                
Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu Cys Val
1265                1270                1275                1280
Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu Gly Asn
                1285                1290                1295    
Pro Tyr Ser Met Leu His Ser Asn Asp His Thr Leu Ser Phe Ile Ala
            1300                1305                1310        
His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser Lys Glu
        1315                1320                1325            
Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Thr Asp Cys Gln Gly
    1330                1335                1340                
Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro Ser Ser
1345                1350                1355                1360
Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn Ala Val
                1365                1370                1375    
Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Thr Leu Pro Leu
            1380                1385                1390        
Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu Leu Gly
        1395                1400                1405            
Leu Glu Thr Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala Glu Gly
    1410                1415                1420                
Asp Glu Leu Val Val Pro Glu Thr Ser Asp Asn Ser Arg Lys Gln Met
1425                1430                1435                1440
Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val Pro Glu
                1445                1450                1455    
Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu Met
            1460                1465                1470        
Arg Asn Lys Leu Ile Ser Asn Pro Thr Asn Phe Asn His Ile Ala His
        1475                1480                1485            
Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro Met Asn
    1490                1495                1500                
Pro Arg Pro Gln Glu Ser Arg Thr Val Phe Ser Gly Ser Val Ser Ile
1505                1510                1515                1520
Pro Ser Ile Thr Lys Ser Arg Pro Glu Pro Gly Arg Ser Met Ser Ala
                1525                1530                1535    
Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser Ala Leu
            1540                1545                1550        
Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln Pro Met
        1555                1560                1565            
Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp Gln Gly
    1570                1575                1580                
Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp Ser Pro
1585                1590                1595                1600
Arg His Ser Thr Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro Pro Ser
                1605                1610                1615    
Pro Val Ser Pro Arg Lys Thr Lys Ser Leu Ser Leu Glu Ser Thr Asp
            1620                1625                1630        
Arg Gly Ser Trp Asp Pro
        1635            


<210> 5888
<211> 1638
<212> PRT
<213> Homo sapiens

<400> 5888
Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp
 1               5                  10                  15      
Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu
            20                  25                  30          
Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg
        35                  40                  45              
Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr
    50                  55                  60                  
Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu
65                  70                  75                  80  
Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu
                85                  90                  95      
Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu
            100                 105                 110         
Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val
        115                 120                 125             
Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe
    130                 135                 140                 
Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly
145                 150                 155                 160 
Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp
                165                 170                 175     
Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val
            180                 185                 190         
His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu
        195                 200                 205             
Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu
    210                 215                 220                 
Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr
225                 230                 235                 240 
Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys
                245                 250                 255     
Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met
            260                 265                 270         
Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val
        275                 280                 285             
Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro
    290                 295                 300                 
Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg
305                 310                 315                 320 
Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp
                325                 330                 335     
Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg
            340                 345                 350         
Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr
        355                 360                 365             
Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met
    370                 375                 380                 
Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val
385                 390                 395                 400 
Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu
                405                 410                 415     
Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln
            420                 425                 430         
Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile
        435                 440                 445             
Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu
    450                 455                 460                 
Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro
465                 470                 475                 480 
Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile
                485                 490                 495     
Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln
            500                 505                 510         
Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg
        515                 520                 525             
Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg
    530                 535                 540                 
Glu Asp Leu Asn Lys Leu Glu Val His Thr Glu Ala Leu Ala Ala Glu
545                 550                 555                 560 
Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser Lys
                565                 570                 575     
Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser Tyr
            580                 585                 590         
Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys Leu
        595                 600                 605             
Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu Ser
    610                 615                 620                 
Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys Glu
625                 630                 635                 640 
Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile Met
                645                 650                 655     
Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser Glu
            660                 665                 670         
Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu Lys
        675                 680                 685             
Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp Lys
    690                 695                 700                 
Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu Glu
705                 710                 715                 720 
Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His Trp
                725                 730                 735     
Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp
            740                 745                 750         
Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu
        755                 760                 765             
Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met Pro
    770                 775                 780                 
Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu Glu
785                 790                 795                 800 
Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile Gln
                805                 810                 815     
Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys Lys
            820                 825                 830         
Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile Glu
        835                 840                 845             
Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile Glu
    850                 855                 860                 
His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro Thr
865                 870                 875                 880 
Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser Val
                885                 890                 895     
His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly Phe
            900                 905                 910         
Pro Pro Lys Arg Lys Thr His Gln Phe Phe Val Lys Ser Phe Thr Thr
        915                 920                 925             
Pro Thr Lys Cys His Gln Cys Thr Ser Leu Met Val Gly Leu Ile Arg
    930                 935                 940                 
Gln Gly Cys Ser Cys Glu Val Cys Gly Phe Ser Cys His Ile Thr Cys
945                 950                 955                 960 
Val Asn Lys Ala Pro Thr Thr Cys Pro Val Pro Pro Glu Gln Thr Lys
                965                 970                 975     
Gly Pro Leu Gly Ile Asp Pro Gln Lys Gly Ile Gly Thr Ala Tyr Glu
            980                 985                 990         
Gly His Val Arg Ile Pro Lys Pro Ala Gly Val Lys Lys Gly Trp Gln
        995                 1000                1005            
Arg Ala Leu Ala Ile Val Cys Asp Phe Lys Leu Phe Leu Tyr Asp Ile
    1010                1015                1020                
Ala Glu Gly Lys Ala Ser Gln Pro Ser Val Val Ile Ser Gln Val Ile
1025                1030                1035                1040
Asp Met Arg Asp Glu Glu Phe Ser Val Ser Ser Val Leu Ala Ser Asp
                1045                1050                1055    
Val Ile His Ala Ser Arg Lys Asp Ile Pro Cys Ile Phe Arg Val Thr
            1060                1065                1070        
Ala Ser Gln Leu Ser Ala Ser Asn Asn Lys Cys Ser Ile Leu Met Leu
        1075                1080                1085            
Ala Asp Thr Glu Asn Glu Lys Asn Lys Trp Val Gly Val Leu Ser Glu
    1090                1095                1100                
Leu His Lys Ile Leu Lys Lys Asn Lys Phe Arg Asp Arg Ser Val Tyr
1105                1110                1115                1120
Val Pro Lys Glu Ala Tyr Asp Ser Thr Leu Pro Leu Ile Lys Thr Thr
                1125                1130                1135    
Gln Ala Ala Ala Ile Ile Asp His Glu Arg Ile Ala Leu Gly Asn Glu
            1140                1145                1150        
Glu Gly Leu Phe Val Val His Val Thr Lys Asp Glu Ile Ile Arg Val
        1155                1160                1165            
Gly Asp Asn Lys Lys Ile His Gln Ile Glu Leu Ile Pro Asn Asp Gln
    1170                1175                1180                
Leu Val Ala Val Ile Ser Gly Arg Asn Arg His Val Arg Leu Phe Pro
1185                1190                1195                1200
Met Ser Ala Leu Asp Gly Arg Glu Thr Asp Phe Tyr Lys Leu Ser Glu
                1205                1210                1215    
Thr Lys Gly Cys Gln Thr Val Thr Ser Gly Lys Val Arg His Gly Ala
            1220                1225                1230        
Leu Thr Cys Leu Cys Val Ala Met Lys Arg Gln Val Leu Cys Tyr Glu
        1235                1240                1245            
Leu Phe Gln Ser Lys Thr Arg His Arg Lys Phe Lys Glu Ile Gln Val
    1250                1255                1260                
Pro Tyr Asn Val Gln Trp Met Ala Ile Phe Ser Glu Gln Leu Cys Val
1265                1270                1275                1280
Gly Phe Gln Ser Gly Phe Leu Arg Tyr Pro Leu Asn Gly Glu Gly Asn
                1285                1290                1295    
Pro Tyr Ser Met Leu His Ser Asn Asp His Thr Leu Ser Phe Ile Ala
            1300                1305                1310        
His Gln Pro Met Asp Ala Ile Cys Ala Val Glu Ile Ser Ser Lys Glu
        1315                1320                1325            
Tyr Leu Leu Cys Phe Asn Ser Ile Gly Ile Tyr Thr Asp Cys Gln Gly
    1330                1335                1340                
Arg Arg Ser Arg Gln Gln Glu Leu Met Trp Pro Ala Asn Pro Ser Ser
1345                1350                1355                1360
Cys Cys Tyr Asn Ala Pro Tyr Leu Ser Val Tyr Ser Glu Asn Ala Val
                1365                1370                1375    
Asp Ile Phe Asp Val Asn Ser Met Glu Trp Ile Gln Thr Leu Pro Leu
            1380                1385                1390        
Lys Lys Val Arg Pro Leu Asn Asn Glu Gly Ser Leu Asn Leu Leu Gly
        1395                1400                1405            
Leu Glu Thr Ile Arg Leu Ile Tyr Phe Lys Asn Lys Met Ala Glu Gly
    1410                1415                1420                
Asp Glu Leu Val Val Pro Glu Thr Ser Asp Asn Ser Arg Lys Gln Met
1425                1430                1435                1440
Val Arg Asn Ile Asn Asn Lys Arg Arg Tyr Ser Phe Arg Val Pro Glu
                1445                1450                1455    
Glu Glu Arg Met Gln Gln Arg Arg Glu Met Leu Arg Asp Pro Glu Met
            1460                1465                1470        
Arg Asn Lys Leu Ile Ser Asn Pro Thr Asn Phe Asn His Ile Ala His
        1475                1480                1485            
Met Gly Pro Gly Asp Gly Ile Gln Ile Leu Lys Asp Leu Pro Met Asn
    1490                1495                1500                
Pro Arg Pro Gln Glu Ser Arg Thr Val Phe Ser Gly Ser Val Ser Ile
1505                1510                1515                1520
Pro Ser Ile Thr Lys Ser Arg Pro Glu Pro Gly Arg Ser Met Ser Ala
                1525                1530                1535    
Ser Ser Gly Leu Ser Ala Arg Ser Ser Ala Gln Asn Gly Ser Ala Leu
            1540                1545                1550        
Lys Arg Glu Phe Ser Gly Gly Ser Tyr Ser Ala Lys Arg Gln Pro Met
        1555                1560                1565            
Pro Ser Pro Ser Glu Gly Ser Leu Ser Ser Gly Gly Met Asp Gln Gly
    1570                1575                1580                
Ser Asp Ala Pro Ala Arg Asp Phe Asp Gly Glu Asp Ser Asp Ser Pro
1585                1590                1595                1600
Arg His Ser Thr Ala Ser Asn Ser Ser Asn Leu Ser Ser Pro Pro Ser
                1605                1610                1615    
Pro Val Ser Pro Arg Lys Thr Lys Ser Leu Ser Leu Glu Ser Thr Asp
            1620                1625                1630        
Arg Gly Ser Trp Asp Pro
        1635            


<210> 5889
<211> 703
<212> PRT
<213> Homo sapiens

<400> 5889
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala
 1               5                  10                  15      
Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln
            20                  25                  30          
Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys
        35                  40                  45              
Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr
    50                  55                  60                  
Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys
65                  70                  75                  80  
Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe
                85                  90                  95      
Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile
            100                 105                 110         
Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu
        115                 120                 125             
Asn Lys Phe Leu Leu Leu Thr Phe Ala Asp Leu Lys Lys Tyr His Phe
    130                 135                 140                 
Tyr Tyr Trp Phe Cys Tyr Pro Ala Leu Cys Leu Pro Glu Ser Leu Pro
145                 150                 155                 160 
Leu Ile Gln Gly Pro Val Gly Leu Asp Gln Arg Phe Ser Leu Lys Gln
                165                 170                 175     
Ile Glu Ala Leu Glu Cys Ala Tyr Asp Asn Leu Cys Gln Thr Glu Gly
            180                 185                 190         
Val Thr Ala Leu Pro Tyr Phe Leu Ile Lys Tyr Asp Glu Asn Met Val
        195                 200                 205             
Leu Val Ser Leu Leu Lys His Tyr Ser Asp Phe Phe Gln Gly Gln Arg
    210                 215                 220                 
Thr Lys Ile Thr Ile Gly Val Tyr Asp Pro Cys Asn Leu Ala Gln Tyr
225                 230                 235                 240 
Pro Gly Trp Pro Leu Arg Asn Phe Leu Val Leu Ala Ala His Arg Trp
                245                 250                 255     
Ser Ser Ser Phe Gln Ser Val Glu Val Val Cys Phe Arg Asp Arg Thr
            260                 265                 270         
Met Gln Gly Ala Arg Asp Val Ala His Ser Ile Ile Phe Glu Val Lys
        275                 280                 285             
Leu Pro Glu Met Ala Phe Ser Pro Asp Cys Pro Lys Ala Val Gly Trp
    290                 295                 300                 
Glu Lys Asn Gln Lys Gly Gly Met Gly Pro Arg Met Val Asn Leu Ser
305                 310                 315                 320 
Glu Cys Met Asp Pro Lys Arg Leu Ala Glu Ser Ser Val Asp Leu Asn
                325                 330                 335     
Leu Lys Leu Met Cys Trp Arg Leu Val Pro Thr Leu Asp Leu Asp Lys
            340                 345                 350         
Val Val Ser Val Lys Cys Leu Leu Leu Gly Ala Gly Thr Leu Gly Cys
        355                 360                 365             
Asn Val Ala Arg Thr Leu Met Gly Trp Gly Val Arg His Ile Thr Phe
    370                 375                 380                 
Val Asp Asn Ala Lys Ile Ser Tyr Ser Asn Pro Val Arg Gln Pro Leu
385                 390                 395                 400 
Tyr Glu Phe Glu Asp Cys Leu Gly Gly Gly Lys Pro Lys Ala Leu Ala
                405                 410                 415     
Ala Ala Asp Arg Leu Gln Lys Ile Phe Pro Gly Val Asn Ala Arg Gly
            420                 425                 430         
Phe Asn Met Ser Ile Pro Met Pro Gly His Pro Val Asn Phe Ser Ser
        435                 440                 445             
Val Thr Leu Glu Gln Ala Arg Arg Asp Val Glu Gln Leu Glu Gln Leu
    450                 455                 460                 
Ile Glu Ser His Asp Val Val Phe Leu Leu Met Asp Thr Arg Glu Ser
465                 470                 475                 480 
Arg Trp Leu Pro Ala Val Ile Ala Ala Ser Lys Arg Lys Leu Val Ile
                485                 490                 495     
Asn Ala Ala Leu Gly Phe Asp Thr Phe Val Val Met Arg His Gly Leu
            500                 505                 510         
Lys Lys Pro Lys Gln Gln Gly Ala Gly Asp Leu Cys Pro Asn His Pro
        515                 520                 525             
Val Ala Ser Ala Asp Leu Leu Gly Ser Ser Leu Phe Ala Asn Ile Pro
    530                 535                 540                 
Gly Tyr Lys Leu Gly Cys Tyr Phe Cys Asn Asp Val Val Ala Pro Gly
545                 550                 555                 560 
Asp Ser Thr Arg Asp Arg Thr Leu Asp Gln Gln Cys Thr Val Ser Arg
                565                 570                 575     
Pro Gly Leu Ala Val Ile Ala Gly Ala Leu Ala Val Glu Leu Met Val
            580                 585                 590         
Ser Val Leu Gln His Pro Glu Gly Gly Tyr Ala Ile Ala Ser Ser Ser
        595                 600                 605             
Asp Asp Arg Met Asn Glu Pro Pro Thr Ser Leu Gly Leu Val Pro His
    610                 615                 620                 
Gln Ile Arg Gly Phe Leu Ser Arg Phe Asp Asn Val Leu Pro Val Ser
625                 630                 635                 640 
Leu Ala Phe Asp Lys Cys Thr Ala Cys Ser Ser Lys Val Leu Asp Gln
                645                 650                 655     
Tyr Glu Arg Glu Gly Phe Asn Phe Leu Ala Lys Val Phe Asn Ser Ser
            660                 665                 670         
His Ser Phe Leu Glu Asp Leu Thr Gly Leu Thr Leu Leu His Gln Glu
        675                 680                 685             
Thr Gln Ala Ala Glu Ile Trp Asp Met Ser Asp Asp Glu Thr Ile
    690                 695                 700             


<210> 5890
<211> 676
<212> PRT
<213> Homo sapiens

<400> 5890
Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala
 1               5                  10                  15      
Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln
            20                  25                  30          
Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys
        35                  40                  45              
Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr
    50                  55                  60                  
Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys
65                  70                  75                  80  
Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe
                85                  90                  95      
Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile
            100                 105                 110         
Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu
        115                 120                 125             
Asn Lys Phe Leu Leu Leu Thr Phe Ala Asp Leu Lys Lys Tyr His Phe
    130                 135                 140                 
Tyr Tyr Trp Phe Cys Tyr Pro Ala Leu Cys Leu Pro Glu Ser Leu Pro
145                 150                 155                 160 
Leu Ile Gln Gly Pro Val Gly Leu Asp Gln Arg Phe Ser Leu Lys Gln
                165                 170                 175     
Ile Glu Ala Leu Glu Cys Ala Tyr Asp Asn Leu Cys Gln Thr Glu Gly
            180                 185                 190         
Val Thr Ala Leu Pro Tyr Phe Leu Ile Lys Tyr Asp Glu Asn Met Val
        195                 200                 205             
Leu Val Ser Leu Leu Lys His Tyr Ser Asp Phe Phe Gln Gly Gln Arg
    210                 215                 220                 
Thr Lys Ile Thr Ile Gly Val Tyr Asp Pro Cys Asn Leu Ala Gln Tyr
225                 230                 235                 240 
Pro Gly Trp Pro Leu Arg Asn Phe Leu Val Leu Ala Ala His Arg Trp
                245                 250                 255     
Ser Ser Ser Phe Gln Ser Val Glu Val Val Cys Phe Arg Asp Arg Thr
            260                 265                 270         
Met Gln Gly Ala Arg Asp Val Ala His Ser Ile Ile Phe Glu Val Lys
        275                 280                 285             
Leu Pro Glu Met Ala Phe Ser Pro Asp Cys Pro Lys Ala Val Gly Trp
    290                 295                 300                 
Glu Lys Asn Gln Lys Gly Gly Met Gly Pro Arg Met Val Asn Leu Ser
305                 310                 315                 320 
Glu Cys Met Asp Pro Lys Arg Leu Ala Glu Ser Ser Val Asp Leu Asn
                325                 330                 335     
Leu Lys Leu Met Cys Trp Arg Leu Val Pro Thr Leu Asp Leu Asp Lys
            340                 345                 350         
Val Val Ser Val Lys Cys Leu Leu Leu Gly Ala Gly Thr Leu Gly Cys
        355                 360                 365             
Asn Val Ala Arg Thr Leu Met Gly Trp Gly Val Arg His Ile Thr Phe
    370                 375                 380                 
Val Asp Asn Ala Lys Ile Ser Tyr Ser Asn Pro Val Arg Gln Pro Leu
385                 390                 395                 400 
Tyr Glu Phe Glu Asp Cys Leu Gly Gly Gly Lys Pro Lys Ala Leu Ala
                405                 410                 415     
Ala Ala Asp Arg Leu Gln Lys Ile Phe Pro Gly Val Asn Ala Arg Gly
            420                 425                 430         
Phe Asn Met Ser Ile Pro Met Pro Gly His Pro Val Asn Phe Ser Ser
        435                 440                 445             
Val Thr Leu Glu Gln Ala Arg Arg Asp Val Glu Gln Leu Glu Gln Leu
    450                 455                 460                 
Ile Glu Ser His Asp Val Val Phe Leu Leu Met Asp Thr Arg Glu Ser
465                 470                 475                 480 
Arg Trp Leu Pro Ala Val Ile Ala Ala Ser Lys Arg Lys Leu Val Ile
                485                 490                 495     
Asn Ala Ala Leu Gly Phe Asp Thr Phe Val Val Met Arg His Gly Leu
            500                 505                 510         
Lys Lys Pro Lys Gln Gln Gly Ala Gly Asp Leu Cys Pro Asn His Pro
        515                 520                 525             
Val Ala Ser Ala Asp Leu Leu Gly Ser Ser Leu Phe Ala Asn Ile Pro
    530                 535                 540                 
Gly Tyr Lys Leu Gly Cys Tyr Phe Cys Asn Asp Val Val Ala Pro Gly
545                 550                 555                 560 
Asp Ser Thr Arg Asp Arg Thr Leu Asp Gln Gln Cys Thr Val Ser Arg
                565                 570                 575     
Pro Gly Leu Ala Val Ile Ala Gly Ala Leu Ala Val Glu Leu Met Val
            580                 585                 590         
Ser Val Leu Gln His Pro Glu Gly Gly Tyr Ala Ile Ala Ser Ser Ser
        595                 600                 605             
Asp Asp Arg Met Asn Glu Pro Pro Thr Ser Leu Gly Leu Val Pro His
    610                 615                 620                 
Gln Val Leu Asp Gln Tyr Glu Arg Glu Gly Phe Asn Phe Leu Ala Lys
625                 630                 635                 640 
Val Phe Asn Ser Ser His Ser Phe Leu Glu Asp Leu Thr Gly Leu Thr
                645                 650                 655     
Leu Leu His Gln Glu Thr Gln Ala Ala Glu Ile Trp Asp Met Ser Asp
            660                 665                 670         
Asp Glu Thr Ile
        675     


<210> 5891
<211> 878
<212> PRT
<213> Homo sapiens

<400> 5891
Met Glu Gln Trp Arg Gln Cys Gly Arg Trp Leu Ile Asp Cys Lys Val
 1               5                  10                  15      
Leu Pro Pro Asn His Arg Val Val Trp Pro Ser Ala Val Val Phe Asp
            20                  25                  30          
Leu Ala Gln Ala Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu His
        35                  40                  45              
Asn Leu Ser Pro Gly Ser Ile Asp Leu Lys Asp Ile Asn Phe Arg Pro
    50                  55                  60                  
Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Lys
65                  70                  75                  80  
Val Cys His Asp Lys Phe Gly Leu Arg Asn Ser Glu Leu Phe Asp Pro
                85                  90                  95      
Phe Asp Leu Phe Asp Val Arg Asp Phe Gly Lys Val Ile Ser Ala Val
            100                 105                 110         
Ser Arg Leu Ser Leu His Ser Ile Ala Gln Asn Lys Gly Ile Arg Pro
        115                 120                 125             
Phe Pro Ser Glu Glu Thr Thr Glu Asn Asp Asp Asp Val Tyr Arg Ser
    130                 135                 140                 
Leu Glu Glu Leu Ala Asp Glu His Asp Leu Gly Glu Asp Ile Tyr Asp
145                 150                 155                 160 
Cys Val Pro Cys Glu Asp Gly Gly Asp Asp Ile Tyr Glu Asp Ile Ile
                165                 170                 175     
Lys Val Glu Val Gln Gln Pro Met Ile Arg Tyr Met Gln Lys Met Gly
            180                 185                 190         
Met Thr Glu Asp Asp Lys Arg Asn Cys Cys Leu Leu Glu Ile Gln Glu
        195                 200                 205             
Thr Glu Ala Lys Tyr Tyr Arg Thr Leu Glu Asp Ile Glu Lys Asn Tyr
    210                 215                 220                 
Met Ser Pro Leu Arg Leu Val Leu Ser Pro Ala Asp Met Ala Ala Val
225                 230                 235                 240 
Phe Ile Asn Leu Glu Asp Leu Ile Lys Val His His Ser Phe Leu Arg
                245                 250                 255     
Ala Ile Asp Val Ser Val Met Val Gly Gly Ser Thr Leu Ala Lys Val
            260                 265                 270         
Phe Leu Asp Phe Lys Glu Arg Leu Leu Ile Tyr Gly Glu Tyr Cys Ser
        275                 280                 285             
His Met Glu His Ala Gln Asn Thr Leu Asn Gln Leu Leu Ala Ser Arg
    290                 295                 300                 
Glu Asp Phe Arg Gln Lys Val Glu Glu Cys Thr Leu Lys Val Gln Asp
305                 310                 315                 320 
Gly Lys Phe Lys Leu Gln Asp Leu Leu Val Val Pro Met Gln Arg Val
                325                 330                 335     
Leu Lys Tyr His Leu Leu Leu Lys Glu Leu Leu Ser His Ser Ala Glu
            340                 345                 350         
Arg Pro Glu Arg Gln Gln Leu Lys Glu Ala Leu Glu Ala Met Gln Asp
        355                 360                 365             
Leu Ala Met Tyr Ile Asn Glu Val Lys Arg Asp Lys Glu Thr Leu Arg
    370                 375                 380                 
Lys Ile Ser Glu Phe Gln Ser Ser Ile Glu Asn Leu Gln Val Lys Leu
385                 390                 395                 400 
Glu Glu Phe Gly Arg Pro Lys Ile Asp Gly Glu Leu Lys Val Arg Ser
                405                 410                 415     
Ile Val Asn His Thr Lys Gln Asp Arg Tyr Leu Phe Leu Phe Asp Lys
            420                 425                 430         
Val Val Ile Val Cys Lys Arg Lys Gly Tyr Ser Tyr Glu Leu Lys Glu
        435                 440                 445             
Ile Ile Glu Leu Leu Phe His Lys Met Thr Asp Asp Pro Met Asn Asn
    450                 455                 460                 
Lys Asp Val Lys Lys Ser His Gly Lys Met Trp Ser Tyr Gly Phe Tyr
465                 470                 475                 480 
Leu Ile His Leu Gln Gly Lys Gln Gly Phe Gln Phe Phe Cys Lys Thr
                485                 490                 495     
Glu Asp Met Lys Arg Lys Trp Met Glu Gln Phe Glu Met Ala Met Ser
            500                 505                 510         
Asn Ile Lys Pro Asp Lys Ala Asn Ala Asn His His Ser Phe Gln Met
        515                 520                 525             
Tyr Thr Phe Asp Lys Thr Thr Asn Cys Lys Ala Cys Lys Met Phe Leu
    530                 535                 540                 
Arg Gly Thr Phe Tyr Gln Gly Tyr Met Cys Thr Lys Cys Gly Val Gly
545                 550                 555                 560 
Ala His Lys Glu Cys Leu Glu Val Ile Pro Pro Cys Lys Phe Thr Ser
                565                 570                 575     
Pro Ala Asp Leu Asp Ala Ser Gly Ala Gly Pro Gly Pro Lys Met Val
            580                 585                 590         
Ala Val Gln Asn Tyr His Gly Asn Pro Ala Pro Pro Gly Lys Pro Val
        595                 600                 605             
Leu Thr Phe Gln Thr Gly Asp Val Leu Glu Leu Leu Arg Gly Asp Pro
    610                 615                 620                 
Glu Ser Pro Trp Trp Glu Gly Arg Leu Val Gln Thr Arg Lys Ser Gly
625                 630                 635                 640 
Tyr Phe Pro Ser Ser Ser Val Lys Pro Cys Pro Val Asp Gly Arg Pro
                645                 650                 655     
Pro Ile Ser Arg Pro Pro Ser Arg Glu Ile Asp Tyr Thr Ala Tyr Pro
            660                 665                 670         
Trp Phe Ala Gly Asn Met Glu Arg Gln Gln Thr Asp Asn Leu Leu Lys
        675                 680                 685             
Ser His Ala Ser Gly Thr Tyr Leu Ile Arg Glu Arg Pro Ala Glu Ala
    690                 695                 700                 
Glu Arg Phe Ala Ile Ser Ile Lys Phe Asn Asp Glu Val Lys His Ile
705                 710                 715                 720 
Lys Val Val Glu Lys Asp Asn Trp Ile His Ile Thr Glu Ala Lys Lys
                725                 730                 735     
Phe Asp Ser Leu Leu Glu Leu Val Glu Tyr Tyr Gln Cys His Ser Leu
            740                 745                 750         
Lys Glu Ser Phe Lys Gln Leu Asp Thr Thr Leu Lys Tyr Pro Tyr Lys
        755                 760                 765             
Ser Arg Glu Arg Ser Ala Ser Arg Ala Ser Ser Arg Ser Pro Ala Ser
    770                 775                 780                 
Cys Ala Ser Tyr Asn Phe Ser Phe Leu Ser Pro Gln Gly Leu Ser Phe
785                 790                 795                 800 
Ala Ser Gln Gly Pro Ser Ala Pro Phe Trp Ser Val Phe Thr Pro Arg
                805                 810                 815     
Val Ile Gly Thr Ala Val Ala Arg Tyr Asn Phe Ala Ala Arg Asp Met
            820                 825                 830         
Arg Glu Leu Ser Leu Arg Glu Gly Asp Val Val Arg Ile Tyr Ser Arg
        835                 840                 845             
Ile Gly Gly Asp Gln Gly Trp Trp Lys Gly Glu Thr Asn Gly Arg Ile
    850                 855                 860                 
Gly Trp Phe Pro Ser Thr Tyr Val Glu Glu Glu Gly Ile Gln
865                 870                 875             


<210> 5892
<211> 332
<212> PRT
<213> Homo sapiens

<400> 5892
Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr
 1               5                  10                  15      
Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala
            20                  25                  30          
Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro
        35                  40                  45              
Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys
    50                  55                  60                  
Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp
65                  70                  75                  80  
Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val
                85                  90                  95      
Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly
            100                 105                 110         
Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu
        115                 120                 125             
Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys
    130                 135                 140                 
Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly
145                 150                 155                 160 
Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu
                165                 170                 175     
Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn
            180                 185                 190         
Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val
        195                 200                 205             
Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys
    210                 215                 220                 
Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr
225                 230                 235                 240 
Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly
                245                 250                 255     
Gly Gly Gly Gly Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr
            260                 265                 270         
Gly Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro
        275                 280                 285             
Gly Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly
    290                 295                 300                 
Pro Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln
305                 310                 315                 320 
Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr
                325                 330         


<210> 5893
<211> 285
<212> PRT
<213> Homo sapiens

<400> 5893
Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr
 1               5                  10                  15      
Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala
            20                  25                  30          
Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro
        35                  40                  45              
Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys
    50                  55                  60                  
Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp
65                  70                  75                  80  
Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val
                85                  90                  95      
Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly
            100                 105                 110         
Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu
        115                 120                 125             
Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys
    130                 135                 140                 
Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly
145                 150                 155                 160 
Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu
                165                 170                 175     
Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn
            180                 185                 190         
Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val
        195                 200                 205             
Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys
    210                 215                 220                 
Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr
225                 230                 235                 240 
Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly
                245                 250                 255     
Gly Gly Gly Gly Gly Gly Gly Gln Gly Ser Thr Asn Tyr Gly Lys Ser
            260                 265                 270         
Gln Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr
        275                 280                 285 


<210> 5894
<211> 628
<212> PRT
<213> Homo sapiens

<400> 5894
Met Ala Ala Ala Gly Ala Gly Pro Gly Gln Glu Ala Gly Ala Gly Pro
 1               5                  10                  15      
Gly Pro Gly Ala Val Ala Asn Ala Thr Gly Ala Glu Glu Gly Glu Met
            20                  25                  30          
Lys Pro Val Ala Ala Gly Ala Ala Ala Pro Pro Gly Glu Gly Ile Ser
        35                  40                  45              
Ala Ala Pro Thr Val Glu Pro Ser Ser Gly Glu Ala Glu Gly Gly Glu
    50                  55                  60                  
Ala Asn Leu Val Asp Val Ser Gly Gly Leu Glu Thr Glu Ser Ser Asn
65                  70                  75                  80  
Gly Lys Asp Thr Leu Glu Gly Ala Gly Asp Thr Ser Glu Val Met Asp
                85                  90                  95      
Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu Gly Glu
            100                 105                 110         
Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala Asp Thr
        115                 120                 125             
Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn Tyr Ser
    130                 135                 140                 
Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe Leu Arg
145                 150                 155                 160 
Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala Asn Leu
                165                 170                 175     
Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met Phe Ser
            180                 185                 190         
Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu Cys Met
        195                 200                 205             
Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn Ile Val
    210                 215                 220                 
Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu His Pro
225                 230                 235                 240 
Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe Gly Leu
                245                 250                 255     
Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn Gln Lys
            260                 265                 270         
Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly Ile Ala
        275                 280                 285             
Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln Gln Asp
    290                 295                 300                 
Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro Leu Phe
305                 310                 315                 320 
Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His Pro Phe
                325                 330                 335     
Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro His Ala
            340                 345                 350         
Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys Pro Ile
        355                 360                 365             
Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu Leu Ala
    370                 375                 380                 
Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg Leu Thr
385                 390                 395                 400 
Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His Gly Val
                405                 410                 415     
Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met Pro Pro
            420                 425                 430         
Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn Leu Gln
        435                 440                 445             
Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser Lys Lys
    450                 455                 460                 
Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser Gly Tyr
465                 470                 475                 480 
Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu Asp Thr
                485                 490                 495     
Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala Leu Ile
            500                 505                 510         
Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val Asp Lys
        515                 520                 525             
Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile Phe Tyr
    530                 535                 540                 
Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe Glu Gly
545                 550                 555                 560 
Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val Ser Ile
                565                 570                 575     
Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr Arg
            580                 585                 590         
Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu Ala
        595                 600                 605             
Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser Pro
    610                 615                 620                 
Pro Trp Glu Pro
625             


<210> 5895
<211> 534
<212> PRT
<213> Homo sapiens

<400> 5895
Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu
 1               5                  10                  15      
Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala
            20                  25                  30          
Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn
        35                  40                  45              
Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe
    50                  55                  60                  
Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala
65                  70                  75                  80  
Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met
                85                  90                  95      
Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu
            100                 105                 110         
Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn
        115                 120                 125             
Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu
    130                 135                 140                 
His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe
145                 150                 155                 160 
Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn
                165                 170                 175     
Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly
            180                 185                 190         
Ile Ala Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln
        195                 200                 205             
Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro
    210                 215                 220                 
Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His
225                 230                 235                 240 
Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro
                245                 250                 255     
His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys
            260                 265                 270         
Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu
        275                 280                 285             
Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg
    290                 295                 300                 
Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His
305                 310                 315                 320 
Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met
                325                 330                 335     
Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn
            340                 345                 350         
Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser
        355                 360                 365             
Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser
    370                 375                 380                 
Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu
385                 390                 395                 400 
Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala
                405                 410                 415     
Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val
            420                 425                 430         
Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile
        435                 440                 445             
Phe Tyr Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe
    450                 455                 460                 
Glu Gly Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val
465                 470                 475                 480 
Ser Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr
                485                 490                 495     
Tyr Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr
            500                 505                 510         
Leu Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg
        515                 520                 525             
Ser Pro Pro Trp Glu Pro
    530                 


<210> 5896
<211> 501
<212> PRT
<213> Homo sapiens

<400> 5896
Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu
 1               5                  10                  15      
Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala
            20                  25                  30          
Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn
        35                  40                  45              
Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe
    50                  55                  60                  
Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala
65                  70                  75                  80  
Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met
                85                  90                  95      
Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu
            100                 105                 110         
Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn
        115                 120                 125             
Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu
    130                 135                 140                 
His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe
145                 150                 155                 160 
Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn
                165                 170                 175     
Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly
            180                 185                 190         
Ile Ala Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln
        195                 200                 205             
Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro
    210                 215                 220                 
Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His
225                 230                 235                 240 
Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro
                245                 250                 255     
His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys
            260                 265                 270         
Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu
        275                 280                 285             
Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg
    290                 295                 300                 
Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His
305                 310                 315                 320 
Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met
                325                 330                 335     
Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn
            340                 345                 350         
Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser
        355                 360                 365             
Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser
    370                 375                 380                 
Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu
385                 390                 395                 400 
Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala
                405                 410                 415     
Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val
            420                 425                 430         
Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Val Ser
        435                 440                 445             
Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr Tyr
    450                 455                 460                 
Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr Leu
465                 470                 475                 480 
Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg Ser
                485                 490                 495     
Pro Pro Trp Glu Pro
            500     


<210> 5897
<211> 1147
<212> PRT
<213> Homo sapiens

<400> 5897
Glu Ser Pro Glu Pro His Pro Leu Gln Asp Asn Gly Ser Phe Leu Trp
 1               5                  10                  15      
Phe Ser Met Met Ser Gln Ser Met Gly Gly Asp Asn Leu Ser Ser Leu
            20                  25                  30          
Asp Thr Asn Glu Ala Glu Ile Glu Pro Glu Asn Met Arg Glu Lys Phe
        35                  40                  45              
Phe Arg Ser Leu Ala Arg Leu Leu Glu Asn Lys Ser Asn Asn Thr Lys
    50                  55                  60                  
Ile Phe Ser Lys Ala Lys Tyr Cys Gln Leu Ile Lys Glu Val Lys Glu
65                  70                  75                  80  
Ala Lys Ala Lys Ala Lys Lys Glu Ser Val Asp Tyr Arg Arg Leu Ala
                85                  90                  95      
Arg Phe Asp Val Ile Leu Val Gln Gly Asn Glu Lys Leu Ile Glu Ala
            100                 105                 110         
Val Asn Gly Glu Thr Asp Lys Ile Arg Tyr Tyr Leu His Ser Glu Asp
        115                 120                 125             
Leu Phe Asp Ile Leu His Asn Thr His Leu Ser Ile Gly His Gly Gly
    130                 135                 140                 
Arg Thr Arg Met Glu Lys Glu Leu Gln Ala Lys Tyr Lys Asn Ile Thr
145                 150                 155                 160 
Lys Glu Val Ile Met Leu Tyr Leu Thr Leu Cys Lys Pro Cys Gln Gln
                165                 170                 175     
Lys Asn Ser Lys Leu Lys Lys Val Leu Thr Ser Lys Ser Ile Lys Glu
            180                 185                 190         
Val Ser Ser Arg Cys Gln Val Asp Leu Ile Asp Met Gln Leu Asn Pro
        195                 200                 205             
Asp Gly Glu Tyr Arg Phe Ile Leu His Tyr Gln Asp Leu Cys Thr Lys
    210                 215                 220                 
Leu Thr Phe Leu Arg Ser Leu Lys Ser Lys Arg Pro Thr Glu Val Ala
225                 230                 235                 240 
His Ala Leu Leu Asp Ile Phe Thr Ile Ile Gly Ala Pro Ser Val Leu
                245                 250                 255     
Gln Ser Asp Asn Gly Arg Glu Phe Ser Ser Gln Val Val Ser Glu Leu
            260                 265                 270         
Ser Asn Ile Trp Pro Glu Leu Lys Ile Val His Gly Lys Ser Gln Thr
        275                 280                 285             
Cys Gln Ser Gln Ser Ser Ala Glu Gln Thr Glu Asp Ile Arg Lys Arg
    290                 295                 300                 
Ile Phe Ser Trp Met Gln Thr Asn Asn Ser Ser His Trp Thr Glu Phe
305                 310                 315                 320 
Leu Trp Phe Ile Gln Met Ser Gln Asn Gln Pro Tyr His Arg Ser Met
                325                 330                 335     
Gln Gln Thr Pro Cys Glu Ser Ala Phe Ser Ser Glu Ala Lys Leu Gly
            340                 345                 350         
Leu Ser His Ser Gln Leu Thr Glu Glu Leu Val Ala Ser Leu His Thr
        355                 360                 365             
Glu Asn Glu Leu Asp Gln Ala Asp Lys Glu Leu Glu Asn Thr Leu Arg
    370                 375                 380                 
Ala Gln Tyr Glu Glu Asn Ile Glu Thr Gly Thr Asp Ser Ser Asp Ile
385                 390                 395                 400 
Glu Glu Asn Leu Ser Val Thr Pro Lys Val Ala Glu Lys Ser Pro Pro
                405                 410                 415     
Glu Ser Arg Leu Arg Phe Leu Ser Cys Val Val Cys Glu Lys Glu Cys
            420                 425                 430         
Thr Gly Val Asn Ser Cys Ile Ser Cys Asp Gly Asn Ile His Ala Ile
        435                 440                 445             
Cys Gly Val Pro Ser Gln His Gly Thr Glu Gly Cys Gly Arg Gln Ile
    450                 455                 460                 
Thr Cys Ser Leu Cys Tyr Glu Thr Ser Thr Met Lys Arg Lys His Asp
465                 470                 475                 480 
Glu Ile Gln Arg Ser Leu Pro Val Lys Pro Ser Lys Met Leu Lys Pro
                485                 490                 495     
Ser Gly Thr Pro Phe Ser Pro Asp Lys Val Gly Asp Trp Met Ala Lys
            500                 505                 510         
Gln Ala Ser Leu Asp Phe Phe Val Lys Lys Arg His Ala Phe Ser Glu
        515                 520                 525             
His Ser Ser Ser Asn Lys Arg Asn Val Asn Asn Arg Ser Tyr Pro Glu
    530                 535                 540                 
Glu Gly Lys Thr Lys Arg Val His Ala Ser Phe Thr Arg Lys Tyr Asp
545                 550                 555                 560 
Pro Ser Tyr Ile Glu Phe Gly Phe Val Ala Val Ile Asp Gly Glu Val
                565                 570                 575     
Leu Lys Pro Gln Cys Ile Ile Cys Gly Asp Val Leu Ala Asn Glu Ala
            580                 585                 590         
Met Lys Pro Ser Lys Leu Lys Arg His Leu Tyr Ser Lys His Lys Glu
        595                 600                 605             
Ile Ser Ser Gln Pro Lys Glu Phe Phe Glu Arg Lys Ser Ser Glu Leu
    610                 615                 620                 
Lys Ser Gln Pro Lys Gln Val Phe Asn Val Ser His Ile Asn Ile Ser
625                 630                 635                 640 
Ala Leu Arg Ala Ser Tyr Lys Val Ala Leu Pro Val Ala Lys Ser Lys
                645                 650                 655     
Thr Pro Tyr Thr Ile Ala Glu Thr Leu Val Lys Asp Cys Ile Lys Glu
            660                 665                 670         
Val Cys Leu Glu Met Leu Gly Glu Ser Ala Ala Lys Lys Val Ala Gln
        675                 680                 685             
Val Pro Leu Ser Asn Asp Thr Ile Ala Arg Arg Ile Gln Glu Leu Ala
    690                 695                 700                 
Asn Asp Met Glu Asp Gln Leu Ile Glu Gln Ile Lys Leu Ala Lys Tyr
705                 710                 715                 720 
Phe Ser Leu Gln Leu Asp Glu Cys Arg Asp Ile Ala Asn Met Ile Ile
                725                 730                 735     
Leu Leu Val Tyr Val Arg Phe Glu His Asp Asp Asp Ile Lys Glu Glu
            740                 745                 750         
Phe Phe Phe Ser Ala Ser Leu Pro Thr Asn Thr Thr Ser Ser Glu Leu
        755                 760                 765             
Tyr Glu Ala Val Lys Asn Tyr Ile Val Asn Lys Cys Gly Leu Glu Phe
    770                 775                 780                 
Lys Phe Cys Val Gly Val Cys Ser Asp Gly Ala Ala Ser Met Thr Gly
785                 790                 795                 800 
Lys His Ser Glu Val Val Thr Gln Ile Lys Glu Leu Ala Pro Glu Cys
                805                 810                 815     
Lys Thr Thr His Cys Phe Ile His Arg Glu Ser Leu Ala Met Lys Lys
            820                 825                 830         
Ile Ser Ala Glu Leu Asn Ser Val Leu Asn Asp Ile Val Lys Ile Val
        835                 840                 845             
Asn Tyr Ile Lys Ser Asn Ser Leu Asn Ser Arg Leu Phe Ser Leu Leu
    850                 855                 860                 
Cys Asp Asn Met Glu Ala Asp His Lys Gln Leu Leu Leu His Ala Glu
865                 870                 875                 880 
Ile Arg Trp Leu Ser Arg Gly Lys Val Leu Ser Arg Met Phe Glu Ile
                885                 890                 895     
Arg Asn Glu Leu Leu Val Phe Leu Gln Gly Lys Lys Pro Met Trp Ser
            900                 905                 910         
Gln Leu Phe Lys Asp Val Asn Trp Thr Ala Arg Leu Ala Tyr Leu Ser
        915                 920                 925             
Asp Ile Phe Ser Ile Phe Asn Asp Leu Asn Ala Ser Met Gln Gly Lys
    930                 935                 940                 
Asn Ala Thr Tyr Phe Ser Met Ala Asp Lys Val Glu Gly Gln Lys Gln
945                 950                 955                 960 
Lys Leu Glu Ala Trp Lys Asn Arg Ile Ser Thr Asp Cys Tyr Asp Met
                965                 970                 975     
Phe His Asn Leu Thr Thr Ile Ile Asn Glu Val Gly Asn Asp Leu Asp
            980                 985                 990         
Ile Ala His Leu Arg Lys Val Ile Ser Glu His Leu Thr Asn Leu Leu
        995                 1000                1005            
Glu Cys Phe Glu Phe Tyr Phe Pro Ser Lys Glu Asp Pro Arg Ile Gly
    1010                1015                1020                
Asn Leu Trp Ile Gln Asn Pro Phe Leu Ser Ser Lys Asp Asn Leu Asn
1025                1030                1035                1040
Leu Thr Val Thr Leu Gln Asp Lys Leu Leu Lys Leu Ala Thr Asp Glu
                1045                1050                1055    
Gly Leu Lys Ile Ser Phe Glu Asn Thr Ala Ser Leu Pro Ser Phe Trp
            1060                1065                1070        
Ile Lys Ala Lys Asn Asp Tyr Pro Glu Leu Ala Glu Ile Ala Leu Lys
        1075                1080                1085            
Leu Leu Leu Leu Phe Pro Ser Thr Tyr Leu Cys Glu Thr Gly Phe Ser
    1090                1095                1100                
Thr Leu Ser Val Ile Lys Thr Lys His Arg Asn Ser Leu Asn Ile His
1105                1110                1115                1120
Tyr Pro Leu Arg Val Ala Leu Ser Ser Ile Gln Pro Arg Leu Asp Lys
                1125                1130                1135    
Leu Thr Ser Lys Lys Gln Ala His Leu Ser His
            1140                1145        


<210> 5898
<211> 782
<212> PRT
<213> Homo sapiens

<400> 5898
Met Glu Ala Val Ser Arg Val Phe Pro Ala Leu Ala Gly Gln Ala Pro
 1               5                  10                  15      
Glu Glu Gln Gly Glu Ile Ile Lys Val Lys Val Lys Glu Glu Asp His
            20                  25                  30          
Thr Trp Asp Gln Glu Ser Ala Leu Arg Arg Asn Leu Ser Tyr Thr Arg
        35                  40                  45              
Glu Leu Ser Arg Gln Arg Phe Arg Gln Phe Cys Tyr Gln Glu Thr Pro
    50                  55                  60                  
Gly Pro Arg Glu Ala Leu Ser Gln Leu Arg Glu Leu Cys Arg Gln Trp
65                  70                  75                  80  
Leu Asn Pro Glu Ile His Thr Lys Glu Gln Ile Leu Glu Leu Leu Val
                85                  90                  95      
Leu Glu Gln Phe Leu Thr Ile Leu Pro Glu Glu Leu Gln Ser Trp Val
            100                 105                 110         
Arg Glu His Asn Pro Glu Ser Gly Glu Glu Val Val Thr Leu Leu Glu
        115                 120                 125             
Asp Leu Glu Arg Glu Leu Asp Glu Pro Arg Gln Gln Val Ser Gln Gly
    130                 135                 140                 
Thr Tyr Gly Gln Glu Val Ser Met Glu Glu Met Ile Pro Leu Asp Ser
145                 150                 155                 160 
Ala Lys Glu Ser Leu Gly Thr Gln Leu Gln Ser Met Glu Asp Arg Met
                165                 170                 175     
Glu Cys Glu Ser Pro Glu Pro His Pro Leu Gln Asp Asn Gly Ser Phe
            180                 185                 190         
Leu Trp Phe Ser Met Met Ser Gln Ser Met Gly Gly Asp Asn Leu Ser
        195                 200                 205             
Ser Leu Asp Thr Asn Glu Ala Glu Ile Glu Pro Glu Asn Met Arg Glu
    210                 215                 220                 
Lys Phe Phe Arg Ser Leu Ala Arg Leu Leu Glu Asn Lys Ser Asn Asn
225                 230                 235                 240 
Thr Lys Ile Phe Ser Lys Ala Lys Tyr Cys Gln Leu Ile Lys Glu Val
                245                 250                 255     
Lys Glu Ala Lys Ala Lys Ala Lys Lys Glu Ser Val Asp Tyr Arg Arg
            260                 265                 270         
Leu Ala Arg Phe Asp Val Ile Leu Val Gln Gly Asn Glu Lys Leu Ile
        275                 280                 285             
Glu Ala Val Asn Gly Glu Thr Asp Lys Ile Arg Tyr Tyr Leu His Ser
    290                 295                 300                 
Glu Asp Leu Phe Asp Ile Leu His Asn Thr His Leu Ser Ile Gly His
305                 310                 315                 320 
Gly Gly Arg Thr Arg Met Glu Lys Glu Leu Gln Ala Lys Tyr Lys Asn
                325                 330                 335     
Ile Thr Lys Glu Val Ile Met Leu Tyr Leu Thr Leu Cys Lys Pro Cys
            340                 345                 350         
Gln Gln Lys Asn Ser Lys Leu Lys Lys Val Leu Thr Ser Lys Ser Ile
        355                 360                 365             
Lys Glu Val Ser Ser Arg Cys Gln Val Asp Leu Ile Asp Met Gln Leu
    370                 375                 380                 
Asn Pro Asp Gly Glu Tyr Arg Phe Ile Leu His Tyr Gln Asp Leu Cys
385                 390                 395                 400 
Thr Lys Leu Thr Phe Leu Arg Ser Leu Lys Ser Lys Arg Pro Thr Glu
                405                 410                 415     
Val Ala His Ala Leu Leu Asp Ile Phe Thr Ile Ile Gly Ala Pro Ser
            420                 425                 430         
Val Leu Gln Ser Asp Asn Gly Arg Glu Phe Ser Ser Gln Val Val Ser
        435                 440                 445             
Glu Leu Ser Asn Ile Trp Pro Glu Leu Lys Ile Val His Gly Lys Ser
    450                 455                 460                 
Gln Thr Cys Gln Ser Gln Ser Ser Ala Glu Gln Thr Glu Asp Ile Arg
465                 470                 475                 480 
Lys Arg Ile Phe Ser Trp Met Gln Thr Asn Asn Ser Ser His Trp Thr
                485                 490                 495     
Glu Phe Leu Trp Phe Ile Gln Met Ser Gln Asn Gln Pro Tyr His Arg
            500                 505                 510         
Ser Met Gln Gln Thr Pro Cys Glu Ser Ala Phe Ser Ser Glu Ala Lys
        515                 520                 525             
Leu Gly Leu Ser His Ser Gln Leu Thr Glu Glu Leu Val Ala Ser Leu
    530                 535                 540                 
His Thr Glu Asn Glu Leu Asp Gln Ala Asp Lys Glu Leu Glu Asn Thr
545                 550                 555                 560 
Leu Arg Ala Gln Tyr Glu Glu Asn Ile Glu Thr Gly Thr Asp Ser Ser
                565                 570                 575     
Asp Ile Glu Glu Asn Leu Ser Val Thr Pro Lys Val Ala Glu Lys Ser
            580                 585                 590         
Pro Pro Glu Ser Arg Leu Arg Phe Leu Ser Cys Val Val Cys Glu Lys
        595                 600                 605             
Glu Cys Thr Gly Val Asn Ser Cys Ile Ser Cys Asp Gly Asn Ile His
    610                 615                 620                 
Ala Ile Cys Gly Val Pro Ser Gln His Gly Thr Glu Gly Cys Gly Arg
625                 630                 635                 640 
Gln Ile Thr Cys Ser Leu Cys Tyr Glu Thr Ser Thr Met Lys Arg Lys
                645                 650                 655     
His Asp Glu Ile Gln Arg Ser Leu Pro Val Lys Pro Ser Lys Met Leu
            660                 665                 670         
Lys Pro Ser Gly Thr Pro Phe Ser Pro Asp Lys Val Gly Asp Trp Met
        675                 680                 685             
Ala Lys Gln Ala Ser Leu Asp Phe Phe Val Lys Lys Arg His Ala Phe
    690                 695                 700                 
Ser Glu His Ser Ser Ser Asn Lys Arg Asn Val Asn Asn Arg Ser Tyr
705                 710                 715                 720 
Pro Glu Glu Gly Lys Thr Lys Arg Val His Ala Ser Phe Thr Arg Lys
                725                 730                 735     
Tyr Asp Pro Ser Tyr Ile Glu Phe Gly Phe Val Ala Val Ile Asp Gly
            740                 745                 750         
Glu Val Leu Lys Pro Gln Cys Ile Ile Cys Gly Asp Val Leu Ala Asn
        755                 760                 765             
Glu Ala Met Lys Pro Ser Lys Leu Lys Arg His Leu Tyr Ser
    770                 775                 780         


<210> 5899
<211> 891
<212> PRT
<213> Homo sapiens

<400> 5899
Met Pro Asp Leu Arg Arg Lys Lys Thr Leu Pro Ile Val Arg Asp Val
 1               5                  10                  15      
Ala Met Thr Leu Ala Ala Arg Lys Ser Gly Leu Ser Leu Ala Met Val
            20                  25                  30          
Ile Arg Thr Ser Leu Asn Asn Glu Glu Leu Lys Met His Val Phe Lys
        35                  40                  45              
Lys Thr Leu Gln Ala Leu Ile Tyr Pro Met Ser Ser Thr Ile Pro His
    50                  55                  60                  
Asn Phe Glu Val Trp Thr Ala Thr Thr Pro Thr Tyr Cys Tyr Glu Cys
65                  70                  75                  80  
Glu Gly Leu Leu Trp Gly Ile Ala Arg Gln Gly Met Lys Cys Leu Glu
                85                  90                  95      
Cys Gly Val Lys Cys His Glu Lys Cys Gln Asp Leu Leu Asn Ala Asp
            100                 105                 110         
Cys Leu Gln Arg Ala Ala Glu Lys Ser Ser Lys His Gly Ala Glu Asp
        115                 120                 125             
Lys Thr Gln Thr Ile Ile Thr Ala Met Lys Glu Arg Met Lys Ile Arg
    130                 135                 140                 
Glu Lys Asn Arg Pro Glu Val Phe Glu Val Ile Gln Glu Met Phe Gln
145                 150                 155                 160 
Ile Ser Lys Glu Asp Phe Val Gln Phe Thr Lys Ala Ala Lys Gln Ser
                165                 170                 175     
Val Leu Asp Gly Thr Ser Lys Trp Ser Ala Lys Ile Thr Ile Thr Val
            180                 185                 190         
Val Ser Ala Gln Gly Leu Gln Ala Lys Asp Lys Thr Gly Ser Ser Asp
        195                 200                 205             
Pro Tyr Val Thr Val Gln Val Gly Lys Asn Lys Arg Arg Thr Lys Thr
    210                 215                 220                 
Ile Phe Gly Asn Leu Asn Pro Val Trp Asp Glu Lys Phe Tyr Phe Glu
225                 230                 235                 240 
Cys His Asn Ser Thr Asp Arg Ile Lys Val Arg Val Trp Asp Glu Asp
                245                 250                 255     
Asp Asp Ile Lys Ser Arg Val Lys Gln His Phe Lys Lys Glu Ser Asp
            260                 265                 270         
Asp Phe Leu Gly Gln Thr Ile Val Glu Val Arg Thr Leu Ser Gly Glu
        275                 280                 285             
Met Asp Val Trp Tyr Asn Leu Glu Lys Arg Thr Asp Lys Ser Ala Val
    290                 295                 300                 
Ser Gly Ala Ile Arg Leu Lys Ile Asn Val Glu Ile Lys Gly Glu Glu
305                 310                 315                 320 
Lys Val Ala Pro Tyr His Ile Gln Tyr Thr Cys Leu His Glu Asn Leu
                325                 330                 335     
Phe His Tyr Leu Thr Glu Val Lys Ser Asn Gly Gly Val Lys Ile Pro
            340                 345                 350         
Glu Val Lys Gly Asp Glu Ala Trp Lys Val Phe Phe Asp Asp Ala Ser
        355                 360                 365             
Gln Glu Ile Val Asp Glu Phe Ala Met Arg Tyr Gly Ile Glu Ser Ile
    370                 375                 380                 
Tyr Gln Ala Met Thr His Phe Ser Cys Leu Ser Ser Lys Tyr Met Cys
385                 390                 395                 400 
Pro Gly Val Pro Ala Val Met Ser Thr Leu Leu Ala Asn Ile Asn Ala
                405                 410                 415     
Phe Tyr Ala His Thr Thr Val Ser Thr Asn Ile Gln Val Ser Ala Ser
            420                 425                 430         
Asp Arg Phe Ala Ala Thr Asn Phe Gly Arg Glu Lys Phe Ile Lys Leu
        435                 440                 445             
Leu Asp Gln Leu His Asn Ser Leu Arg Ile Asp Leu Ser Lys Tyr Arg
    450                 455                 460                 
Glu Asn Phe Pro Ala Ser Asn Thr Glu Arg Leu Gln Asp Leu Lys Ser
465                 470                 475                 480 
Thr Val Asp Leu Leu Thr Ser Ile Thr Phe Phe Arg Met Lys Val Leu
                485                 490                 495     
Glu Leu Gln Ser Pro Pro Lys Ala Ser Met Val Val Lys Asp Cys Val
            500                 505                 510         
Arg Ala Cys Leu Asp Ser Thr Tyr Lys Tyr Ile Phe Asp Asn Cys His
        515                 520                 525             
Glu Leu Tyr Ser Gln Leu Thr Asp Pro Ser Lys Lys Gln Asp Ile Pro
    530                 535                 540                 
Arg Glu Asp Gln Gly Pro Thr Thr Lys Asn Leu Asp Phe Trp Pro Gln
545                 550                 555                 560 
Leu Ile Thr Leu Met Val Thr Ile Ile Asp Glu Asp Lys Thr Ala Tyr
                565                 570                 575     
Thr Pro Val Leu Asn Gln Phe Pro Gln Glu Leu Asn Met Gly Lys Ile
            580                 585                 590         
Ser Ala Glu Ile Met Trp Thr Leu Phe Ala Leu Asp Met Lys Tyr Ala
        595                 600                 605             
Leu Glu Glu His Glu Asn Gln Arg Leu Cys Lys Ser Thr Asp Tyr Met
    610                 615                 620                 
Asn Leu His Phe Lys Val Lys Trp Phe Tyr Asn Glu Tyr Val Arg Glu
625                 630                 635                 640 
Leu Pro Ala Phe Lys Asp Ala Val Pro Glu Tyr Ser Leu Trp Phe Glu
                645                 650                 655     
Pro Phe Val Met Gln Trp Leu Asp Glu Asn Glu Asp Val Ser Met Glu
            660                 665                 670         
Phe Leu His Gly Ala Leu Gly Arg Asp Lys Lys Asp Gly Phe Gln Gln
        675                 680                 685             
Thr Ser Glu His Ala Leu Phe Ser Cys Ser Val Val Asp Val Phe Ala
    690                 695                 700                 
Gln Leu Asn Gln Ser Phe Glu Ile Ile Lys Lys Leu Glu Cys Pro Asn
705                 710                 715                 720 
Pro Glu Ala Leu Ser His Leu Met Arg Arg Phe Ala Lys Thr Ile Asn
                725                 730                 735     
Lys Val Leu Leu Gln Tyr Ala Ala Ile Val Ser Ser Asp Phe Ser Ser
            740                 745                 750         
His Cys Asp Lys Glu Asn Val Pro Cys Ile Leu Met Asn Asn Ile Gln
        755                 760                 765             
Gln Leu Arg Val Gln Leu Glu Lys Met Phe Glu Ser Met Gly Gly Lys
    770                 775                 780                 
Glu Leu Asp Ser Glu Ala Ser Thr Ile Leu Lys Glu Leu Gln Val Lys
785                 790                 795                 800 
Leu Ser Gly Val Leu Asp Glu Leu Ser Val Thr Tyr Gly Glu Ser Phe
                805                 810                 815     
Gln Val Ile Ile Glu Glu Cys Ile Lys Gln Met Ser Phe Glu Leu Asn
            820                 825                 830         
Gln Met Arg Ala Asn Gly Asn Thr Thr Ser Asn Lys Asn Ser Ala Ala
        835                 840                 845             
Met Asp Ala Glu Ile Val Leu Arg Ser Leu Met Asp Phe Leu Asp Lys
    850                 855                 860                 
Thr Leu Ser Leu Ser Ala Lys Ile Cys Glu Lys Thr Val Leu Lys Arg
865                 870                 875                 880 
Val Leu Lys Glu Leu Trp Lys Leu Val Leu Asn
                885                 890     


<210> 5900
<211> 892
<212> PRT
<213> Homo sapiens

<400> 5900
Met Asp Val Trp Tyr Asn Leu Glu Lys Arg Thr Asp Lys Ser Ala Val
 1               5                  10                  15      
Ser Gly Ala Ile Arg Leu Lys Ile Asn Val Glu Ile Lys Gly Glu Glu
            20                  25                  30          
Lys Val Ala Pro Tyr His Ile Gln Tyr Thr Cys Leu His Glu Asn Leu
        35                  40                  45              
Phe His Tyr Leu Thr Glu Val Lys Ser Asn Gly Gly Val Lys Ile Pro
    50                  55                  60                  
Glu Val Lys Gly Asp Glu Ala Trp Lys Val Phe Phe Asp Asp Ala Ser
65                  70                  75                  80  
Gln Glu Ile Val Asp Glu Phe Ala Met Arg Tyr Gly Ile Glu Ser Ile
                85                  90                  95      
Tyr Gln Ala Met Thr His Phe Ser Cys Leu Ser Ser Lys Tyr Met Cys
            100                 105                 110         
Pro Gly Val Pro Ala Val Met Ser Thr Leu Leu Ala Asn Ile Asn Ala
        115                 120                 125             
Phe Tyr Ala His Thr Thr Val Ser Thr Asn Ile Gln Val Ser Ala Ser
    130                 135                 140                 
Asp Arg Phe Ala Ala Thr Asn Phe Gly Arg Glu Lys Phe Ile Lys Leu
145                 150                 155                 160 
Leu Asp Gln Leu His Asn Ser Leu Arg Ile Asp Leu Ser Lys Tyr Arg
                165                 170                 175     
Glu Asn Phe Pro Ala Ser Asn Thr Glu Arg Leu Gln Asp Leu Lys Ser
            180                 185                 190         
Thr Val Asp Leu Leu Thr Ser Ile Thr Phe Phe Arg Met Lys Val Leu
        195                 200                 205             
Glu Leu Gln Ser Pro Pro Lys Ala Ser Met Val Val Lys Asp Cys Val
    210                 215                 220                 
Arg Ala Cys Leu Asp Ser Thr Tyr Lys Tyr Ile Phe Asp Asn Cys His
225                 230                 235                 240 
Glu Leu Tyr Ser Gln Leu Thr Asp Pro Ser Lys Lys Gln Asp Ile Pro
                245                 250                 255     
Arg Glu Asp Gln Gly Pro Thr Thr Lys Asn Leu Asp Phe Trp Pro Gln
            260                 265                 270         
Leu Ile Thr Leu Met Val Thr Ile Ile Asp Glu Asp Lys Thr Ala Tyr
        275                 280                 285             
Thr Pro Val Leu Asn Gln Phe Pro Gln Glu Leu Asn Met Gly Lys Ile
    290                 295                 300                 
Ser Ala Glu Ile Met Trp Thr Leu Phe Ala Leu Asp Met Lys Tyr Ala
305                 310                 315                 320 
Leu Glu Glu His Glu Asn Gln Arg Leu Cys Lys Ser Thr Asp Tyr Met
                325                 330                 335     
Asn Leu His Phe Lys Val Lys Trp Phe Tyr Asn Glu Tyr Val Arg Glu
            340                 345                 350         
Leu Pro Ala Phe Lys Asp Ala Val Pro Glu Tyr Ser Leu Trp Phe Glu
        355                 360                 365             
Pro Phe Val Met Gln Trp Leu Asp Glu Asn Glu Asp Val Ser Met Glu
    370                 375                 380                 
Phe Leu His Gly Ala Leu Gly Arg Asp Lys Lys Asp Gly Phe Gln Gln
385                 390                 395                 400 
Thr Ser Glu His Ala Leu Phe Ser Cys Ser Val Val Asp Val Phe Ala
                405                 410                 415     
Gln Leu Asn Gln Ser Phe Glu Ile Ile Lys Lys Leu Glu Cys Pro Asn
            420                 425                 430         
Pro Glu Ala Leu Ser His Leu Met Arg Arg Phe Ala Lys Thr Ile Asn
        435                 440                 445             
Lys Val Leu Leu Gln Tyr Ala Ala Ile Val Ser Ser Asp Phe Ser Ser
    450                 455                 460                 
His Cys Asp Lys Glu Asn Val Pro Cys Ile Leu Met Asn Asn Ile Gln
465                 470                 475                 480 
Gln Leu Arg Val Gln Leu Glu Lys Met Phe Glu Ser Met Gly Gly Lys
                485                 490                 495     
Glu Leu Asp Ser Glu Ala Ser Thr Ile Leu Lys Glu Leu Gln Val Lys
            500                 505                 510         
Leu Ser Gly Val Leu Asp Glu Leu Ser Val Thr Tyr Gly Glu Ser Phe
        515                 520                 525             
Gln Val Ile Ile Glu Glu Cys Ile Lys Gln Met Ser Phe Glu Leu Asn
    530                 535                 540                 
Gln Met Arg Ala Asn Gly Asn Thr Thr Ser Asn Lys Asn Ser Ala Ala
545                 550                 555                 560 
Met Asp Ala Glu Ile Val Leu Arg Ser Leu Met Asp Phe Leu Asp Lys
                565                 570                 575     
Thr Leu Ser Leu Ser Ala Lys Ile Cys Glu Lys Thr Val Leu Lys Arg
            580                 585                 590         
Val Leu Lys Glu Leu Trp Lys Leu Val Leu Asn Lys Ile Glu Lys Gln
        595                 600                 605             
Ile Val Leu Pro Pro Leu Thr Asp Gln Thr Gly Pro Gln Met Ile Phe
    610                 615                 620                 
Ile Ala Ala Lys Asp Leu Gly Gln Leu Ser Lys Leu Lys Glu His Met
625                 630                 635                 640 
Ile Arg Glu Asp Ala Arg Gly Leu Thr Pro Arg Gln Cys Ala Ile Met
                645                 650                 655     
Glu Val Val Leu Ala Thr Ile Lys Gln Tyr Phe His Ala Gly Gly Asn
            660                 665                 670         
Gly Leu Lys Lys Asn Phe Leu Glu Lys Ser Pro Asp Leu Gln Ser Leu
        675                 680                 685             
Arg Tyr Ala Leu Ser Leu Tyr Thr Gln Thr Thr Asp Ala Leu Ile Lys
    690                 695                 700                 
Lys Phe Ile Asp Thr Gln Thr Ser Gln Ser Arg Ser Ser Lys Asp Ala
705                 710                 715                 720 
Val Gly Gln Ile Ser Val His Val Asp Ile Thr Ala Thr Pro Gly Thr
                725                 730                 735     
Gly Asp His Lys Val Thr Val Lys Val Ile Ala Ile Asn Asp Leu Asn
            740                 745                 750         
Trp Gln Thr Thr Ala Met Phe Arg Pro Phe Val Glu Val Cys Ile Leu
        755                 760                 765             
Gly Pro Asn Leu Gly Asp Lys Lys Arg Lys Gln Gly Thr Lys Thr Lys
    770                 775                 780                 
Ser Asn Thr Trp Ser Pro Lys Tyr Asn Glu Thr Phe Gln Phe Ile Leu
785                 790                 795                 800 
Gly Lys Glu Asn Arg Pro Gly Ala Tyr Glu Leu His Leu Ser Val Lys
                805                 810                 815     
Asp Tyr Cys Phe Ala Arg Glu Asp Arg Ile Ile Gly Met Thr Val Ile
            820                 825                 830         
Gln Leu Gln Asn Ile Ala Glu Lys Gly Ser Tyr Gly Ala Trp Tyr Pro
        835                 840                 845             
Leu Leu Lys Asn Ile Ser Met Asp Glu Thr Gly Leu Thr Ile Leu Arg
    850                 855                 860                 
Ile Leu Ser Gln Arg Thr Ser Asp Asp Val Ala Lys Glu Phe Val Arg
865                 870                 875                 880 
Leu Lys Ser Glu Thr Arg Ser Thr Glu Glu Ser Ala
                885                 890         


<210> 5901
<211> 2147
<212> PRT
<213> Homo sapiens

<400> 5901
Met Ala Ala Phe Gly Leu Leu Ser Tyr Glu Gln Arg Pro Leu Lys Arg
 1               5                  10                  15      
Pro Arg Leu Gly Pro Pro Asp Val Tyr Pro Gln Asp Pro Lys Gln Lys
            20                  25                  30          
Glu Asp Glu Leu Thr Ala Val Asn Val Lys Gln Gly Phe Asn Asn Gln
        35                  40                  45              
Pro Ala Phe Thr Gly Asp Glu His Gly Ser Ala Arg Asn Ile Val Ile
    50                  55                  60                  
Asn Pro Ser Lys Ile Gly Ala Tyr Phe Ser Ser Ile Leu Ala Glu Lys
65                  70                  75                  80  
Leu Lys Leu Asn Thr Phe Gln Asp Thr Gly Lys Lys Lys Pro Gln Val
                85                  90                  95      
Asn Ala Lys Asp Asn Tyr Trp Leu Val Thr Ala Arg Ser Gln Ser Ala
            100                 105                 110         
Ile His Ser Trp Phe Ser Asp Leu Ala Gly Asn Lys Pro Leu Ser Ile
        115                 120                 125             
Leu Ala Lys Lys Val Pro Ile Leu Ser Lys Lys Glu Asp Val Phe Ala
    130                 135                 140                 
Tyr Leu Ala Lys Tyr Ser Val Pro Met Val Arg Ala Thr Trp Leu Ile
145                 150                 155                 160 
Lys Met Thr Cys Ala Tyr Tyr Ser Ala Ile Ser Glu Ala Lys Ile Lys
                165                 170                 175     
Lys Arg Gln Ala Pro Asp Pro Asn Leu Glu Trp Thr Gln Ile Ser Thr
            180                 185                 190         
Arg Tyr Leu Arg Glu Gln Leu Ala Lys Ile Ser Asp Phe Tyr His Met
        195                 200                 205             
Ala Ser Ser Thr Gly Asp Gly Pro Val Pro Val Pro Pro Glu Val Glu
    210                 215                 220                 
Gln Ala Met Lys Gln Trp Glu Tyr Asn Glu Lys Leu Ala Phe His Met
225                 230                 235                 240 
Phe Gln Glu Gly Met Leu Glu Lys His Glu Tyr Leu Thr Trp Ile Leu
                245                 250                 255     
Asp Val Leu Glu Lys Ile Arg Pro Met Asp Asp Asp Leu Leu Lys Leu
            260                 265                 270         
Leu Leu Pro Leu Met Leu Gln Tyr Ser Asp Glu Phe Val Gln Ser Ala
        275                 280                 285             
Tyr Leu Ser Arg Arg Leu Ala Tyr Phe Cys Ala Arg Arg Leu Ser Leu
    290                 295                 300                 
Leu Leu Ser Asp Ser Pro Asn Leu Leu Ala Ala His Ser Pro His Met
305                 310                 315                 320 
Met Ile Gly Pro Asn Asn Ser Ser Ile Gly Ala Pro Ser Pro Gly Pro
                325                 330                 335     
Pro Gly Pro Gly Met Ser Pro Val Gln Leu Ala Phe Ser Asp Phe Leu
            340                 345                 350         
Ser Cys Ala Gln His Gly Pro Leu Val Tyr Gly Leu Ser Cys Met Leu
        355                 360                 365             
Gln Thr Val Thr Leu Cys Cys Pro Ser Ala Leu Val Trp Asn Tyr Ser
    370                 375                 380                 
Thr Asn Glu Asn Lys Ser Ala Asn Pro Gly Ser Pro Leu Asp Leu Leu
385                 390                 395                 400 
Gln Val Ala Pro Ser Ser Leu Pro Met Pro Gly Gly Asn Thr Ala Phe
                405                 410                 415     
Asn Gln Gln Val Arg Ala Arg Ile Tyr Glu Val Glu Gln Gln Ile Lys
            420                 425                 430         
Gln Arg Gly Arg Ala Val Glu Val Arg Trp Ser Phe Asp Lys Cys Gln
        435                 440                 445             
Glu Ser Thr Ala Gly Val Thr Ile Ser Arg Val Leu His Thr Leu Glu
    450                 455                 460                 
Val Leu Asp Arg His Cys Phe Asp Arg Thr Asp Ser Ser Asn Ser Met
465                 470                 475                 480 
Glu Thr Leu Tyr His Lys Ile Phe Trp Ala Asn Gln Asn Lys Asp Asn
                485                 490                 495     
Gln Glu Val Ala Pro Asn Asp Glu Ala Val Val Thr Leu Leu Cys Glu
            500                 505                 510         
Trp Ala Val Ser Cys Lys Arg Ser Gly Lys His Arg Ala Met Ala Val
        515                 520                 525             
Ala Lys Leu Leu Glu Lys Arg Gln Ala Glu Ile Glu Ala Glu Arg Cys
    530                 535                 540                 
Gly Glu Ser Glu Val Leu Asp Glu Lys Glu Ser Ile Ser Ser Ser Ser
545                 550                 555                 560 
Leu Ala Gly Ser Ser Leu Pro Val Phe Gln Asn Val Leu Leu Arg Phe
                565                 570                 575     
Leu Asp Thr Gln Ala Pro Ser Leu Ser Asp Pro Asn Ser Glu Cys Glu
            580                 585                 590         
Lys Val Glu Phe Val Asn Leu Val Leu Leu Phe Cys Glu Phe Ile Arg
        595                 600                 605             
His Asp Val Phe Ser His Asp Ala Tyr Met Cys Thr Leu Ile Ser Arg
    610                 615                 620                 
Gly Asp Leu Ser Val Thr Ala Ser Thr Arg Pro Arg Ser Pro Val Gly
625                 630                 635                 640 
Glu Asn Ala Asp Glu His Tyr Ser Lys Asp His Asp Val Lys Met Glu
                645                 650                 655     
Ile Phe Ser Pro Met Pro Gly Glu Ser Cys Glu Asn Ala Asn Thr Ser
            660                 665                 670         
Leu Gly Arg Arg Met Ser Val Asn Cys Glu Lys Leu Val Lys Arg Glu
        675                 680                 685             
Lys Pro Arg Glu Leu Ile Phe Pro Ser Asn Tyr Asp Leu Leu Arg His
    690                 695                 700                 
Leu Gln Tyr Ala Thr His Phe Pro Ile Pro Leu Asp Glu Ser Ser Ser
705                 710                 715                 720 
His Glu Cys Asn Gln Arg Thr Ile Leu Leu Tyr Gly Val Gly Lys Glu
                725                 730                 735     
Arg Asp Glu Ala Arg His Gln Leu Lys Lys Ile Thr Lys Asp Ile Leu
            740                 745                 750         
Lys Ile Leu Asn Lys Lys Ser Thr Thr Glu Thr Gly Val Gly Asp Glu
        755                 760                 765             
Gly Gln Lys Ala Arg Lys Asn Lys Gln Glu Thr Phe Pro Thr Leu Glu
    770                 775                 780                 
Thr Val Phe Thr Lys Leu Gln Leu Leu Ser Tyr Phe Asp Gln His Gln
785                 790                 795                 800 
Val Thr Ser Gln Ile Ser Asn Asn Val Leu Glu Gln Ile Thr Ser Phe
                805                 810                 815     
Ala Ser Gly Thr Ser Tyr His Leu Pro Leu Ala His His Ile Gln Leu
            820                 825                 830         
Ile Phe Asp Leu Met Glu Pro Ala Leu Asn Ile Asn Gly Leu Ile Asp
        835                 840                 845             
Phe Ala Ile Gln Leu Leu Asn Glu Leu Ser Val Val Glu Ala Glu Leu
    850                 855                 860                 
Leu Leu Lys Ser Ser Ser Leu Ala Gly Ser Tyr Thr Thr Gly Leu Cys
865                 870                 875                 880 
Val Cys Ile Val Ala Val Leu Arg Arg Tyr His Ser Cys Leu Ile Leu
                885                 890                 895     
Asn Pro Asp Gln Thr Ala Gln Val Phe Glu Gly Leu Cys Gly Val Val
            900                 905                 910         
Lys His Val Val Asn Pro Ser Glu Cys Ser Ser Pro Glu Arg Cys Ile
        915                 920                 925             
Leu Ala Tyr Leu Tyr Asp Leu Tyr Val Ser Cys Ser His Leu Arg Ser
    930                 935                 940                 
Lys Phe Gly Asp Leu Phe Ser Ser Ala Cys Ser Lys Val Lys Gln Thr
945                 950                 955                 960 
Ile Tyr Asn Asn Val Met Pro Ala Asn Ser Asn Leu Arg Trp Asp Pro
                965                 970                 975     
Asp Phe Met Met Asp Phe Ile Glu Asn Pro Ser Ala Arg Ser Ile Asn
            980                 985                 990         
Tyr Ser Met Leu Gly Lys Ile Leu Ser Asp Asn Ala Ala Asn Arg Tyr
        995                 1000                1005            
Ser Phe Val Cys Asn Thr Leu Met Asn Val Cys Met Gly His Gln Asp
    1010                1015                1020                
Ala Gly Arg Ile Asn Asp Ile Ala Asn Phe Ser Ser Glu Leu Thr Ala
1025                1030                1035                1040
Cys Cys Thr Val Leu Ser Ser Glu Trp Leu Gly Val Leu Lys Ala Leu
                1045                1050                1055    
Cys Cys Ser Ser Asn His Val Trp Gly Phe Asn Asp Val Leu Cys Thr
            1060                1065                1070        
Val Asp Val Ser Asp Leu Ser Phe His Asp Ser Leu Ala Thr Phe Ile
        1075                1080                1085            
Ala Ile Leu Ile Ala Arg Gln Cys Phe Ser Leu Glu Asp Val Val Gln
    1090                1095                1100                
His Val Ala Leu Pro Ser Leu Leu Ala Ala Ala Cys Gly Asp Ala Asp
1105                1110                1115                1120
Ala Glu Pro Gly Ala Arg Met Thr Cys Arg Leu Leu Leu His Leu Phe
                1125                1130                1135    
Arg Ala Pro Gln Ala Cys Phe Leu Pro Gln Ala Thr Gly Lys Pro Phe
            1140                1145                1150        
Pro Gly Ile Arg Ser Ser Cys Asp Arg His Leu Leu Ala Ala Ala His
        1155                1160                1165            
Asn Ser Ile Glu Val Gly Ala Val Phe Ala Val Leu Lys Ala Ile Met
    1170                1175                1180                
Met Leu Gly Asp Ala Lys Ile Gly Asn Asn Ser Val Ser Ser Leu Lys
1185                1190                1195                1200
Asn Asp Asp Phe Thr Met Arg Gly Leu Arg Cys Asp Gly Asn Ala Asp
                1205                1210                1215    
Asp Ile Trp Thr Ala Ser Gln Asn Pro Lys Ser Cys Gly Lys Ser Ile
            1220                1225                1230        
Ser Ile Glu Thr Ala Asn Leu Arg Glu Tyr Ala Arg Tyr Val Leu Arg
        1235                1240                1245            
Thr Ile Cys Gln Gln Glu Trp Val Gly Glu His Cys Leu Lys Glu Pro
    1250                1255                1260                
Glu Arg Leu Cys Thr Asp Lys Glu Leu Ile Leu Asp Pro Val Leu Ser
1265                1270                1275                1280
Asn Met Gln Ala Gln Lys Leu Leu Gln Leu Ile Cys Tyr Pro His Gly
                1285                1290                1295    
Ile Lys Glu Cys Thr Glu Gly Asp Asn Leu Gln Arg Gln His Ile Lys
            1300                1305                1310        
Arg Ile Leu Gln Asn Leu Glu Gln Trp Thr Leu Arg Gln Ser Trp Leu
        1315                1320                1325            
Glu Leu Gln Leu Met Ile Lys Gln Cys Leu Lys Asp Pro Gly Ser Gly
    1330                1335                1340                
Ser Val Ala Glu Met Asn Asn Leu Leu Asp Asn Ile Ala Lys Ala Thr
1345                1350                1355                1360
Ile Glu Val Phe Gln Gln Ser Ala Asp Leu Asn Asn Ser Ser Asn Ser
                1365                1370                1375    
Gly Met Ser Leu Phe Asn Pro Asn Ser Ile Gly Ser Ala Asp Thr Ser
            1380                1385                1390        
Ser Thr Arg Gln Asn Gly Ile Lys Thr Phe Leu Ser Ser Ser Glu Arg
        1395                1400                1405            
Arg Gly Val Trp Leu Val Ala Pro Leu Ile Ala Arg Leu Pro Thr Ser
    1410                1415                1420                
Val Gln Gly Arg Val Leu Lys Ala Ala Gly Glu Glu Leu Glu Lys Gly
1425                1430                1435                1440
Gln His Leu Gly Ser Ser Ser Lys Lys Glu Arg Asp Arg Gln Lys Gln
                1445                1450                1455    
Lys Ser Met Ser Leu Leu Ser Gln Gln Pro Phe Leu Ser Leu Val Leu
            1460                1465                1470        
Thr Cys Leu Lys Gly Gln Asp Glu Gln Arg Glu Gly Leu Leu Thr Ser
        1475                1480                1485            
Leu Gln Asn Gln Val Asn Gln Ile Leu Ser Asn Trp Arg Glu Glu Arg
    1490                1495                1500                
Tyr Gln Asp Asp Ile Lys Ala Arg Gln Met Met His Glu Ala Leu Gln
1505                1510                1515                1520
Leu Arg Leu Asn Leu Val Gly Gly Met Phe Asp Thr Val Gln Arg Ser
                1525                1530                1535    
Thr Gln Trp Thr Thr Asp Trp Ala Leu Leu Leu Leu Gln Ile Ile Thr
            1540                1545                1550        
Ser Gly Thr Val Asp Met His Thr Asn Asn Glu Leu Phe Thr Thr Val
        1555                1560                1565            
Leu Asp Met Leu Gly Val Leu Ile Asn Gly Thr Leu Ala Ser Asp Leu
    1570                1575                1580                
Ser Asn Ala Ser Pro Gly Gly Ser Glu Glu Asn Lys Arg Ala Tyr Met
1585                1590                1595                1600
Asn Leu Val Lys Lys Leu Lys Lys Glu Leu Gly Asp Lys Arg Ser Glu
                1605                1610                1615    
Ser Ile Asp Lys Val Arg Gln Leu Leu Pro Leu Pro Lys Gln Thr Cys
            1620                1625                1630        
Asp Val Ile Thr Cys Glu Pro Met Gly Ser Leu Ile Asp Thr Lys Gly
        1635                1640                1645            
Asn Lys Ile Ala Gly Phe Asp Ser Ile Asp Lys Lys Gln Ala Arg Gly
    1650                1655                1660                
Leu Gln Val Ser Thr Lys Gln Lys Val Ser Pro Trp Asp Leu Phe Glu
1665                1670                1675                1680
Gly Gln Lys Asn Pro Ala Pro Leu Ser Trp Ala Trp Phe Gly Thr Val
                1685                1690                1695    
Arg Val Asp Arg Arg Val Ile Lys Tyr Glu Glu Gln His His Leu Leu
            1700                1705                1710        
Leu Tyr His Thr His Pro Met Pro Lys Pro Arg Ser Tyr Tyr Leu Gln
        1715                1720                1725            
Pro Leu Pro Leu Pro Pro Glu Glu Glu Glu Glu Glu Pro Thr Ser Pro
    1730                1735                1740                
Val Ser Gln Glu Pro Glu Arg Lys Ser Ala Glu Leu Ser Asp Gln Gly
1745                1750                1755                1760
Lys Thr Thr Thr Asp Glu Glu Lys Lys Thr Lys Gly Arg Lys Arg Lys
                1765                1770                1775    
Thr Lys Ser Ser Ser Arg Val Asp Glu Tyr Pro Gln Ser Asn Ile Tyr
            1780                1785                1790        
Arg Val Pro Pro Asn Tyr Ser Pro Ile Ser Ser Gln Met Met His His
        1795                1800                1805            
Pro Gln Ser Thr Leu Trp Gly Tyr Asn Leu Val Gly Gln Pro Gln Gln
    1810                1815                1820                
Pro Gly Phe Phe Leu Gln Asn Gln Ser Leu Thr Pro Gly Gly Ser Arg
1825                1830                1835                1840
Leu Asp Pro Ala Gly Ser Phe Val Pro Thr Asn Thr Lys Gln Ala Leu
                1845                1850                1855    
Ser Asn Met Leu Gln Arg Arg Ser Gly Ala Met Met Gln Pro Pro Ser
            1860                1865                1870        
Leu His Ala Ile Thr Ser Gln Gln Gln Leu Ile Gln Met Lys Leu Leu
        1875                1880                1885            
Gln Gln Gln Gln Gln Gln Arg Leu Leu Arg Gln Ala Gln Thr Arg Pro
    1890                1895                1900                
Phe Gln Gln Gly Gln Pro Gly Asp Gln Ala Ala Leu Phe Ala Ala Gln
1905                1910                1915                1920
Ala Arg Pro Ser Pro Gln Leu Pro Gln Tyr Pro Gly Leu Gln Gln Ala
                1925                1930                1935    
Gln Thr Met Pro Gln Gly Tyr Thr Met Tyr Gly Thr Gln Met Pro Leu
            1940                1945                1950        
Gln Gln Thr Ser Gln Gln Gln Ala Gly Ser Val Val Leu Ser Pro Ser
        1955                1960                1965            
Tyr Asn Ser Arg Ala Tyr Pro Ala Ala His Ser Asn Pro Val Leu Met
    1970                1975                1980                
Glu Arg Leu Arg Gln Ile Gln Gln Gln Pro Ser Gly Tyr Val Gln Gln
1985                1990                1995                2000
Gln Ala Ser Pro Tyr Leu Gln Pro Leu Thr Gly Ser Gln Arg Leu Asn
                2005                2010                2015    
His Gln Ala Leu Gln Gln Ser Pro Leu Val Gly Gly Gly Ile Asp Ala
            2020                2025                2030        
Val Leu Thr Ser Ala His Pro Asn Leu Pro Ser Val Pro Leu Pro Gln
        2035                2040                2045            
Asp Pro Met Arg Pro Arg Gln Pro Gln Val Arg Gln Gln Gln Arg Leu
    2050                2055                2060                
Leu Gln Met Gln Gln Pro Gln Gln Pro Gln Pro Gln Gln Pro Pro Gln
2065                2070                2075                2080
Pro Gln Gln Ser Ser Gln Ser Gln Ser Gln Thr Leu Gly Leu Gln Ala
                2085                2090                2095    
Met Gln Pro Gln Gln Pro Leu Phe Pro Arg Gln Gly Leu Gln Gln Thr
            2100                2105                2110        
Gln Gln Gln Gln Gln Thr Ala Ala Leu Val Arg Gln Leu Gln Lys Gln
        2115                2120                2125            
Leu Ser Ser Asn Gln Pro Gln Gln Gly Val Thr Pro Tyr Gly His Pro
    2130                2135                2140                
Ser His Phe
2145        


<210> 5902
<211> 255
<212> PRT
<213> Homo sapiens

<400> 5902
Met Val Met Ser Ser Tyr Met Val Asn Ser Lys Tyr Val Asp Pro Lys
 1               5                  10                  15      
Phe Pro Pro Cys Glu Glu Tyr Leu Gln Gly Gly Tyr Leu Gly Glu Gln
            20                  25                  30          
Gly Ala Asp Tyr Tyr Gly Gly Gly Ala Gln Gly Ala Asp Phe Gln Pro
        35                  40                  45              
Pro Gly Leu Tyr Pro Arg Pro Asp Phe Gly Glu Gln Pro Phe Gly Gly
    50                  55                  60                  
Ser Gly Pro Gly Pro Gly Ser Ala Leu Pro Ala Arg Gly His Gly Gln
65                  70                  75                  80  
Glu Pro Gly Gly Pro Gly Gly His Tyr Ala Ala Pro Gly Glu Pro Cys
                85                  90                  95      
Pro Ala Pro Pro Ala Pro Pro Pro Ala Pro Leu Pro Gly Ala Arg Ala
            100                 105                 110         
Tyr Ser Gln Ser Asp Pro Lys Gln Pro Pro Ser Gly Thr Ala Leu Lys
        115                 120                 125             
Gln Pro Ala Val Val Tyr Pro Trp Met Lys Lys Val His Val Asn Ser
    130                 135                 140                 
Val Asn Pro Asn Tyr Thr Gly Gly Glu Pro Lys Arg Ser Arg Thr Ala
145                 150                 155                 160 
Tyr Thr Arg Gln Gln Val Leu Glu Leu Glu Lys Glu Phe His Phe Asn
                165                 170                 175     
Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Thr Leu Cys
            180                 185                 190         
Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys
        195                 200                 205             
Trp Lys Lys Asp His Lys Leu Pro Asn Thr Lys Gly Arg Ser Ser Ser
    210                 215                 220                 
Ser Ser Ser Ser Ser Ser Cys Ser Ser Ser Val Ala Pro Ser Gln His
225                 230                 235                 240 
Leu Gln Pro Met Ala Lys Asp His His Thr Asp Leu Thr Thr Leu
                245                 250                 255 


<210> 5903
<211> 1137
<212> PRT
<213> Homo sapiens

<400> 5903
Met Ser Asp Ile Val Glu Lys Thr Leu Thr Ala Leu Pro Gly Leu Phe
 1               5                  10                  15      
Leu Gln Asn Gln Pro Gly Gly Gly Pro Ala Ala Ala Lys Ala Ser Phe
            20                  25                  30          
Ser Ser Arg Leu Gly Ser Leu Val Arg Gly Ile Thr Ala Leu Thr Ser
        35                  40                  45              
Lys His Glu Glu Glu Lys Leu Ile Gln Gln Glu Leu Ser Ser Leu Lys
    50                  55                  60                  
Ala Thr Val Ser Ala Pro Thr Thr Thr Leu Lys Met Met Lys Glu Cys
65                  70                  75                  80  
Met Val Arg Leu Ile Tyr Cys Glu Met Leu Gly Tyr Asp Ala Ser Phe
                85                  90                  95      
Gly Tyr Ile His Ala Ile Lys Leu Ala Gln Gln Gly Asn Leu Leu Glu
            100                 105                 110         
Lys Arg Val Gly Tyr Leu Ala Val Ser Leu Phe Leu His Glu Ser His
        115                 120                 125             
Glu Leu Leu Leu Leu Leu Val Asn Thr Val Val Lys Asp Leu Gln Ser
    130                 135                 140                 
Thr Asn Leu Val Glu Val Cys Met Ala Leu Thr Val Val Ser Gln Ile
145                 150                 155                 160 
Phe Pro Arg Glu Met Ile Pro Ala Val Leu Pro Leu Ile Glu Asp Lys
                165                 170                 175     
Leu Gln His Ser Lys Glu Ile Val Arg Arg Lys Ala Val Leu Ala Leu
            180                 185                 190         
Tyr Lys Phe His Leu Ile Ala Pro Asn Gln Val Gln His Ile His Ile
        195                 200                 205             
Lys Phe Arg Lys Ala Leu Cys Asp Arg Asp Val Gly Val Met Ala Ala
    210                 215                 220                 
Ser Leu His Ile Tyr Leu Arg Met Ile Lys Glu Asn Ser Ser Gly Tyr
225                 230                 235                 240 
Lys Asp Leu Thr Gly Ser Phe Val Thr Ile Leu Lys Gln Val Val Gly
                245                 250                 255     
Gly Lys Leu Pro Val Glu Phe Asn Tyr His Ser Val Pro Ala Pro Trp
            260                 265                 270         
Leu Gln Ile Gln Leu Leu Arg Ile Leu Gly Leu Leu Gly Lys Asp Asp
        275                 280                 285             
Gln Arg Thr Ser Glu Leu Met Tyr Asp Val Leu Asp Glu Ser Leu Arg
    290                 295                 300                 
Arg Ala Glu Leu Asn His Asn Val Thr Tyr Ala Ile Leu Phe Glu Cys
305                 310                 315                 320 
Val His Thr Val Tyr Ser Ile Tyr Pro Lys Ser Glu Leu Leu Glu Lys
                325                 330                 335     
Ala Ala Lys Cys Ile Gly Lys Phe Val Leu Ser Pro Lys Ile Asn Leu
            340                 345                 350         
Lys Tyr Leu Gly Leu Lys Ala Leu Thr Tyr Val Ile Gln Gln Asp Pro
        355                 360                 365             
Thr Leu Ala Leu Gln His Gln Met Thr Ile Ile Glu Cys Leu Asp His
    370                 375                 380                 
Pro Asp Pro Ile Ile Lys Arg Glu Thr Leu Glu Leu Leu Tyr Arg Ile
385                 390                 395                 400 
Thr Asn Ala Gln Asn Ile Thr Val Ile Val Gln Lys Met Leu Glu Tyr
                405                 410                 415     
Leu His Gln Ser Lys Glu Glu Tyr Val Ile Val Asn Leu Val Gly Lys
            420                 425                 430         
Ile Ala Glu Leu Ala Glu Lys Tyr Ala Pro Asp Asn Ala Trp Phe Ile
        435                 440                 445             
Gln Thr Met Asn Ala Val Phe Ser Val Gly Gly Asp Val Met His Pro
    450                 455                 460                 
Asp Ile Pro Asn Asn Phe Leu Arg Leu Leu Ala Glu Gly Phe Asp Asp
465                 470                 475                 480 
Glu Thr Glu Asp Gln Gln Leu Arg Leu Tyr Ala Val Gln Ser Tyr Leu
                485                 490                 495     
Thr Leu Leu Asp Met Glu Asn Val Phe Tyr Pro Gln Arg Phe Leu Gln
            500                 505                 510         
Val Met Ser Trp Val Leu Gly Glu Tyr Ser Tyr Leu Leu Asp Lys Glu
        515                 520                 525             
Thr Pro Glu Glu Val Ile Ala Lys Leu Tyr Lys Leu Leu Met Asn Asp
    530                 535                 540                 
Ser Val Ser Ser Glu Thr Lys Ala Trp Leu Ile Ala Ala Val Thr Lys
545                 550                 555                 560 
Leu Thr Ser Gln Ala His Ser Ser Asn Thr Val Glu Arg Leu Ile His
                565                 570                 575     
Glu Phe Thr Ile Ser Leu Asp Thr Cys Met Arg Gln His Ala Phe Glu
            580                 585                 590         
Leu Lys His Leu His Glu Asn Val Glu Leu Met Lys Ser Leu Leu Pro
        595                 600                 605             
Val Asp Arg Ser Cys Glu Asp Leu Val Val Asp Ala Ser Leu Ser Phe
    610                 615                 620                 
Leu Asp Gly Phe Val Ala Glu Gly Leu Ser Gln Gly Ala Ala Pro Tyr
625                 630                 635                 640 
Lys Pro Pro His Gln Arg Gln Glu Glu Lys Leu Ser Gln Glu Lys Val
                645                 650                 655     
Leu Asn Phe Glu Pro Tyr Gly Leu Ser Phe Ser Ser Ser Gly Phe Thr
            660                 665                 670         
Gly Arg Gln Ser Pro Ala Gly Ile Ser Leu Gly Ser Asp Val Ser Gly
        675                 680                 685             
Asn Ser Ala Glu Thr Gly Leu Lys Glu Thr Asn Ser Leu Lys Leu Glu
    690                 695                 700                 
Gly Ile Lys Lys Leu Trp Gly Lys Glu Gly Tyr Leu Pro Lys Lys Glu
705                 710                 715                 720 
Ser Lys Thr Gly Asp Glu Ser Gly Ala Leu Pro Val Pro Gln Glu Ser
                725                 730                 735     
Ile Met Glu Asn Val Asp Gln Ala Ile Thr Lys Lys Asp Gln Ser Gln
            740                 745                 750         
Val Leu Thr Gln Ser Lys Glu Glu Lys Glu Lys Gln Leu Leu Ala Ser
        755                 760                 765             
Ser Leu Phe Val Gly Leu Gly Ser Glu Ser Thr Ile Asn Leu Leu Gly
    770                 775                 780                 
Lys Ala Asp Thr Val Ser His Lys Phe Arg Arg Lys Ser Lys Val Lys
785                 790                 795                 800 
Glu Ala Lys Ser Gly Glu Thr Thr Ser Thr His Asn Met Thr Cys Ser
                805                 810                 815     
Ser Phe Ser Ser Leu Ser Asn Val Ala Tyr Glu Asp Asp Tyr Tyr Ser
            820                 825                 830         
Asn Thr Leu His Asp Thr Gly Asp Lys Glu Leu Lys Lys Phe Ser Leu
        835                 840                 845             
Thr Ser Glu Leu Leu Asp Ser Glu Ser Leu Thr Glu Leu Pro Leu Val
    850                 855                 860                 
Glu Lys Phe Ser Tyr Cys Ser Leu Ser Thr Pro Ser Leu Phe Ala Asn
865                 870                 875                 880 
Asn Asn Met Glu Ile Phe His Pro Pro Gln Ser Thr Ala Ala Ser Val
                885                 890                 895     
Ala Lys Glu Ser Ser Leu Ala Ser Ser Phe Leu Glu Glu Thr Thr Glu
            900                 905                 910         
Tyr Ile His Ser Asn Ala Met Glu Val Cys Asn Asn Glu Thr Ile Ser
        915                 920                 925             
Val Ser Ser Tyr Lys Ile Trp Lys Asp Asp Cys Leu Leu Met Val Trp
    930                 935                 940                 
Ser Val Thr Asn Lys Ser Gly Leu Glu Leu Lys Ser Ala Asp Leu Glu
945                 950                 955                 960 
Ile Phe Pro Ala Glu Asn Phe Lys Val Thr Glu Gln Pro Gly Cys Cys
                965                 970                 975     
Leu Pro Val Met Glu Ala Glu Ser Thr Lys Ser Phe Gln Tyr Ser Val
            980                 985                 990         
Gln Ile Glu Lys Pro Phe Thr Glu Gly Asn Leu Thr Gly Phe Ile Ser
        995                 1000                1005            
Tyr His Met Met Asp Thr His Ser Ala Gln Leu Glu Phe Ser Val Asn
    1010                1015                1020                
Leu Ser Leu Leu Asp Phe Ile Arg Pro Leu Lys Ile Ser Ser Asp Asp
1025                1030                1035                1040
Phe Gly Lys Leu Trp Leu Ser Phe Ala Asn Asp Val Lys Gln Asn Val
                1045                1050                1055    
Lys Met Ser Glu Ser Gln Ala Ala Leu Pro Ser Ala Leu Lys Thr Leu
            1060                1065                1070        
Gln Gln Lys Leu Arg Leu His Ile Ile Glu Ile Ile Gly Asn Glu Gly
        1075                1080                1085            
Leu Leu Ala Cys Gln Leu Leu Pro Ser Ile Pro Cys Leu Leu His Cys
    1090                1095                1100                
Arg Val His Ala Asp Val Leu Ala Leu Trp Phe Arg Ser Ser Cys Ser
1105                1110                1115                1120
Thr Leu Pro Asp Tyr Leu Leu Tyr Gln Cys Gln Lys Val Met Glu Gly
                1125                1130                1135    
Ser
    


<210> 5904
<211> 851
<212> PRT
<213> Homo sapiens

<400> 5904
Met Ala Lys Ser Ala Leu Arg Glu Asn Gly Thr Asn Ser Glu Thr Phe
 1               5                  10                  15      
Arg Gln Arg Phe Arg Arg Phe His Tyr Gln Glu Val Ala Gly Pro Arg
            20                  25                  30          
Glu Ala Phe Ser Gln Leu Trp Glu Leu Cys Cys Arg Trp Leu Arg Pro
        35                  40                  45              
Glu Val Arg Thr Lys Glu Gln Ile Val Glu Leu Leu Val Leu Glu Gln
    50                  55                  60                  
Phe Leu Thr Val Leu Pro Gly Glu Ile Gln Asn Trp Val Gln Glu Gln
65                  70                  75                  80  
Cys Pro Glu Asn Gly Glu Glu Ala Val Thr Leu Val Glu Asp Leu Glu
                85                  90                  95      
Arg Glu Pro Gly Arg Pro Arg Ser Ser Val Thr Val Ser Val Lys Gly
            100                 105                 110         
Gln Glu Val Arg Leu Glu Lys Met Thr Pro Pro Lys Ser Ser Gln Glu
        115                 120                 125             
Leu Leu Ser Val Arg Gln Glu Ser Val Glu Pro Gln Pro Arg Gly Val
    130                 135                 140                 
Pro Lys Lys Glu Arg Ala Arg Ser Pro Asp Leu Gly Pro Gln Glu Gln
145                 150                 155                 160 
Met Asn Pro Lys Glu Lys Leu Lys Pro Phe Gln Arg Ser Gly Leu Pro
                165                 170                 175     
Phe Pro Lys Ser Gly Val Val Ser Arg Leu Glu Gln Gly Glu Pro Trp
            180                 185                 190         
Ile Pro Asp Leu Leu Gly Ser Lys Glu Lys Glu Leu Pro Ser Gly Ser
        195                 200                 205             
His Ile Gly Asp Arg Arg Val His Ala Asp Leu Leu Pro Ser Lys Lys
    210                 215                 220                 
Asp Arg Arg Ser Trp Val Glu Gln Asp His Trp Ser Phe Glu Asp Glu
225                 230                 235                 240 
Lys Val Ala Gly Val His Trp Gly Tyr Glu Glu Thr Arg Thr Leu Leu
                245                 250                 255     
Ala Ile Leu Ser Gln Thr Glu Phe Tyr Glu Ala Leu Arg Asn Cys His
            260                 265                 270         
Arg Asn Ser Gln Val Tyr Gly Ala Val Ala Glu Arg Leu Arg Glu Tyr
        275                 280                 285             
Gly Phe Leu Arg Thr Leu Glu Gln Cys Arg Thr Lys Phe Lys Gly Leu
    290                 295                 300                 
Gln Lys Ser Tyr Arg Lys Val Lys Ser Gly His Pro Pro Glu Thr Cys
305                 310                 315                 320 
Pro Phe Phe Glu Glu Met Glu Ala Leu Met Ser Ala Gln Val Ile Ala
                325                 330                 335     
Leu Pro Ser Asn Gly Leu Glu Ala Ala Ala Ser His Ser Gly Leu Val
            340                 345                 350         
Gly Ser Asp Ala Glu Thr Glu Glu Pro Gly Gln Arg Gly Trp Gln His
        355                 360                 365             
Glu Glu Gly Ala Glu Glu Ala Val Ala Gln Glu Ser Asp Ser Asp Asp
    370                 375                 380                 
Met Asp Leu Glu Ala Thr Pro Gln Asp Pro Asn Ser Ala Ala Pro Val
385                 390                 395                 400 
Val Phe Arg Ser Pro Gly Gly Val His Trp Gly Tyr Glu Glu Thr Lys
                405                 410                 415     
Thr Tyr Leu Ala Ile Leu Ser Glu Thr Gln Phe Tyr Glu Ala Leu Arg
            420                 425                 430         
Asn Cys His Arg Asn Ser Gln Leu Tyr Gly Ala Val Ala Glu Arg Leu
        435                 440                 445             
Trp Glu Tyr Gly Phe Leu Arg Thr Pro Glu Gln Cys Arg Thr Lys Phe
    450                 455                 460                 
Lys Ser Leu Gln Thr Ser Tyr Arg Lys Val Lys Asn Gly Gln Ala Pro
465                 470                 475                 480 
Glu Thr Cys Pro Phe Phe Glu Glu Met Asp Ala Leu Val Ser Val Arg
                485                 490                 495     
Val Ala Ala Pro Pro Asn Asp Gly Gln Glu Glu Thr Ala Ser Cys Pro
            500                 505                 510         
Val Gln Gly Thr Ser Glu Ala Glu Ala Gln Lys Gln Ala Glu Glu Ala
        515                 520                 525             
Asp Glu Ala Thr Glu Glu Asp Ser Asp Asp Asp Glu Glu Asp Thr Glu
    530                 535                 540                 
Ile Pro Pro Gly Ala Val Ile Thr Arg Ala Pro Val Leu Phe Gln Ser
545                 550                 555                 560 
Pro Arg Gly Phe Glu Ala Gly Phe Glu Asn Glu Asp Asn Ser Lys Arg
                565                 570                 575     
Asp Ile Ser Glu Glu Val Gln Leu His Arg Thr Leu Leu Ala Arg Ser
            580                 585                 590         
Glu Arg Lys Ile Pro Arg Tyr Leu His Gln Gly Lys Gly Asn Glu Ser
        595                 600                 605             
Asp Cys Arg Ser Gly Arg Gln Trp Ala Lys Thr Ser Gly Glu Lys Arg
    610                 615                 620                 
Gly Lys Leu Thr Leu Pro Glu Lys Ser Leu Ser Glu Val Leu Ser Gln
625                 630                 635                 640 
Gln Arg Pro Cys Leu Gly Glu Arg Pro Tyr Lys Tyr Leu Lys Tyr Ser
                645                 650                 655     
Lys Ser Phe Gly Pro Asn Ser Leu Leu Met His Gln Val Ser His Gln
            660                 665                 670         
Val Glu Asn Pro Tyr Lys Cys Ala Asp Cys Gly Lys Ser Phe Ser Arg
        675                 680                 685             
Ser Ala Arg Leu Ile Arg His Arg Arg Ile His Thr Gly Glu Lys Pro
    690                 695                 700                 
Tyr Lys Cys Leu Asp Cys Gly Lys Ser Phe Arg Asp Ser Ser Asn Phe
705                 710                 715                 720 
Ile Thr His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Gly
                725                 730                 735     
Glu Cys Gly Lys Cys Phe Asn Gln Ser Ser Ser Leu Ile Ile His Gln
            740                 745                 750         
Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys
        755                 760                 765             
Ser Phe Asn Asn Ser Ser His Phe Ser Ala His Arg Arg Ile His Thr
    770                 775                 780                 
Gly Glu Arg Pro His Val Cys Pro Asp Cys Gly Lys Ser Phe Ser Lys
785                 790                 795                 800 
Ser Ser Asp Leu Arg Ala His His Arg Thr His Thr Gly Glu Lys Pro
                805                 810                 815     
Tyr Gly Cys His Asp Cys Gly Lys Cys Phe Ser Lys Ser Ser Ala Leu
            820                 825                 830         
Asn Lys His Gly Glu Ile His Ala Arg Glu Lys Leu Leu Thr Gln Ser
        835                 840                 845             
Ala Pro Lys
    850     


<210> 5905
<211> 1093
<212> PRT
<213> Homo sapiens

<400> 5905
Met Ala Gly Ala Ala Gly Leu Thr Ala Glu Val Ser Trp Lys Val Leu
 1               5                  10                  15      
Glu Arg Arg Ala Arg Thr Lys Arg Ser Gly Ser Val Tyr Glu Pro Leu
            20                  25                  30          
Lys Ser Ile Asn Leu Pro Arg Pro Asp Asn Glu Thr Leu Trp Asp Lys
        35                  40                  45              
Leu Asp His Tyr Tyr Arg Ile Val Lys Ser Thr Leu Leu Leu Tyr Gln
    50                  55                  60                  
Ser Pro Thr Thr Gly Leu Phe Pro Thr Lys Thr Cys Gly Gly Asp Gln
65                  70                  75                  80  
Lys Ala Lys Ile Gln Asp Ser Leu Tyr Cys Ala Ala Gly Ala Trp Ala
                85                  90                  95      
Leu Ala Leu Ala Tyr Arg Arg Ile Asp Asp Asp Lys Gly Arg Thr His
            100                 105                 110         
Glu Leu Glu His Ser Ala Ile Lys Cys Met Arg Gly Ile Leu Tyr Cys
        115                 120                 125             
Tyr Met Arg Gln Ala Asp Lys Val Gln Gln Phe Lys Gln Asp Pro Arg
    130                 135                 140                 
Pro Thr Thr Cys Leu His Ser Val Phe Asn Val His Thr Gly Asp Glu
145                 150                 155                 160 
Leu Leu Ser Tyr Glu Glu Tyr Gly His Leu Gln Ile Asn Ala Val Ser
                165                 170                 175     
Leu Tyr Leu Leu Tyr Leu Val Glu Met Ile Ser Ser Gly Leu Gln Ile
            180                 185                 190         
Ile Tyr Asn Thr Asp Glu Val Ser Phe Ile Gln Asn Leu Val Phe Cys
        195                 200                 205             
Val Glu Arg Val Tyr Arg Val Pro Asp Phe Gly Val Trp Glu Arg Gly
    210                 215                 220                 
Ser Lys Tyr Asn Asn Gly Ser Thr Glu Leu His Ser Ser Ser Val Gly
225                 230                 235                 240 
Leu Ala Lys Ala Ala Leu Glu Ala Ile Asn Gly Phe Asn Leu Phe Gly
                245                 250                 255     
Asn Gln Gly Cys Ser Trp Ser Val Ile Phe Val Asp Leu Asp Ala His
            260                 265                 270         
Asn Arg Asn Arg Gln Thr Leu Cys Ser Leu Leu Pro Arg Glu Ser Arg
        275                 280                 285             
Ser His Asn Thr Asp Ala Ala Leu Leu Pro Cys Ile Ser Tyr Pro Ala
    290                 295                 300                 
Phe Ala Leu Asp Asp Glu Val Leu Phe Ser Gln Thr Leu Asp Lys Val
305                 310                 315                 320 
Val Arg Lys Leu Lys Gly Lys Tyr Gly Phe Lys Arg Phe Leu Arg Asp
                325                 330                 335     
Gly Tyr Arg Thr Ser Leu Glu Asp Pro Asn Arg Cys Tyr Tyr Lys Pro
            340                 345                 350         
Ala Glu Ile Lys Leu Phe Asp Gly Ile Glu Cys Glu Phe Pro Ile Phe
        355                 360                 365             
Phe Leu Tyr Met Met Ile Asp Gly Val Phe Arg Gly Asn Pro Lys Gln
    370                 375                 380                 
Val Gln Glu Tyr Gln Asp Leu Leu Thr Pro Val Leu His His Thr Thr
385                 390                 395                 400 
Glu Gly Tyr Pro Val Val Pro Lys Tyr Tyr Tyr Val Pro Ala Asp Phe
                405                 410                 415     
Val Glu Tyr Glu Lys Asn Asn Pro Gly Ser Gln Lys Arg Phe Pro Ser
            420                 425                 430         
Asn Cys Gly Arg Asp Gly Lys Leu Phe Leu Trp Gly Gln Ala Leu Tyr
        435                 440                 445             
Ile Ile Ala Lys Leu Leu Ala Asp Glu Leu Ile Ser Pro Lys Asp Ile
    450                 455                 460                 
Asp Pro Val Gln Arg Tyr Val Pro Leu Lys Asp Gln Arg Asn Val Ser
465                 470                 475                 480 
Met Arg Phe Ser Asn Gln Gly Pro Leu Glu Asn Asp Leu Val Val His
                485                 490                 495     
Val Ala Leu Ile Ala Glu Ser Gln Arg Leu Gln Val Phe Leu Asn Thr
            500                 505                 510         
Tyr Gly Ile Gln Thr Gln Thr Pro Gln Gln Val Glu Pro Ile Gln Ile
        515                 520                 525             
Trp Pro Gln Gln Glu Leu Val Lys Ala Tyr Leu Gln Leu Gly Ile Asn
    530                 535                 540                 
Glu Lys Leu Gly Leu Ser Gly Arg Pro Asp Arg Pro Ile Gly Cys Leu
545                 550                 555                 560 
Gly Thr Ser Lys Ile Tyr Arg Ile Leu Gly Lys Thr Val Val Cys Tyr
                565                 570                 575     
Pro Ile Ile Phe Asp Leu Ser Asp Phe Tyr Met Ser Gln Asp Val Phe
            580                 585                 590         
Leu Leu Ile Asp Asp Ile Lys Asn Ala Leu Gln Phe Ile Lys Gln Tyr
        595                 600                 605             
Trp Lys Met His Gly Arg Pro Leu Phe Leu Val Leu Ile Arg Glu Asp
    610                 615                 620                 
Asn Ile Arg Gly Ser Arg Phe Asn Pro Ile Leu Asp Met Leu Ala Ala
625                 630                 635                 640 
Leu Lys Lys Gly Ile Ile Gly Gly Val Lys Val His Val Asp Arg Leu
                645                 650                 655     
Gln Thr Leu Ile Ser Gly Ala Val Val Glu Gln Leu Asp Phe Leu Arg
            660                 665                 670         
Ile Ser Asp Thr Glu Glu Leu Pro Glu Phe Lys Ser Phe Glu Glu Leu
        675                 680                 685             
Glu Pro Pro Lys His Ser Lys Val Lys Arg Gln Ser Ser Thr Pro Ser
    690                 695                 700                 
Ala Pro Glu Leu Gly Gln Gln Pro Asp Val Asn Ile Ser Glu Trp Lys
705                 710                 715                 720 
Asp Lys Pro Thr His Glu Ile Leu Gln Lys Leu Asn Asp Cys Ser Cys
                725                 730                 735     
Leu Ala Ser Gln Ala Ile Leu Leu Gly Ile Leu Leu Lys Arg Glu Gly
            740                 745                 750         
Pro Asn Phe Ile Thr Lys Glu Gly Thr Val Ser Asp His Ile Glu Arg
        755                 760                 765             
Val Tyr Arg Arg Ala Gly Ser Gln Lys Leu Trp Leu Ala Val Arg Tyr
    770                 775                 780                 
Gly Ala Ala Phe Thr Gln Lys Phe Ser Ser Ser Ile Ala Pro His Ile
785                 790                 795                 800 
Thr Thr Phe Leu Val His Gly Lys Gln Val Thr Leu Gly Ala Phe Gly
                805                 810                 815     
His Glu Glu Glu Val Ile Ser Asn Pro Leu Ser Pro Arg Val Ile Gln
            820                 825                 830         
Asn Ile Ile Tyr Tyr Lys Cys Asn Thr His Asp Glu Arg Glu Ala Val
        835                 840                 845             
Ile Gln Gln Glu Leu Val Ile His Ile Gly Trp Ile Ile Ser Asn Asn
    850                 855                 860                 
Pro Glu Leu Phe Ser Gly Met Leu Lys Ile Arg Ile Gly Trp Ile Ile
865                 870                 875                 880 
His Ala Met Glu Tyr Glu Leu Gln Ile Arg Gly Gly Asp Lys Pro Ala
                885                 890                 895     
Leu Asp Leu Tyr Gln Leu Ser Pro Ser Glu Val Lys Gln Leu Leu Leu
            900                 905                 910         
Asp Ile Leu Gln Pro Gln Gln Asn Gly Arg Cys Trp Leu Asn Arg Arg
        915                 920                 925             
Gln Ile Asp Gly Ser Leu Asn Arg Thr Pro Thr Gly Phe Tyr Asp Arg
    930                 935                 940                 
Val Trp Gln Ile Leu Glu Arg Thr Pro Asn Gly Ile Ile Val Ala Gly
945                 950                 955                 960 
Lys His Leu Pro Gln Gln Pro Thr Leu Ser Asp Met Thr Met Tyr Glu
                965                 970                 975     
Met Asn Phe Ser Leu Leu Val Glu Asp Thr Leu Gly Asn Ile Asp Gln
            980                 985                 990         
Pro Gln Tyr Arg Gln Ile Val Val Glu Leu Leu Met Val Val Ser Ile
        995                 1000                1005            
Val Leu Glu Arg Asn Pro Glu Leu Glu Phe Gln Asp Lys Val Asp Leu
    1010                1015                1020                
Asp Arg Leu Val Lys Glu Ala Phe Asn Glu Phe Gln Lys Asp Gln Ser
1025                1030                1035                1040
Arg Leu Lys Glu Ile Glu Lys Gln Asp Asp Met Thr Ser Phe Tyr Asn
                1045                1050                1055    
Thr Pro Pro Leu Gly Lys Arg Gly Thr Cys Ser Tyr Leu Thr Lys Ala
            1060                1065                1070        
Val Met Asn Leu Leu Leu Glu Gly Glu Val Lys Pro Asn Asn Asp Asp
        1075                1080                1085            
Pro Cys Leu Ile Ser
    1090            


<210> 5906
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 5906
Met Ala Cys Ser Pro Asp Ala Val Val Ser Pro Ser Ser Ala Phe Leu
 1               5                  10                  15      
Arg Ser Gly Ser Val Tyr Glu Pro Leu Lys Ser Ile Asn Leu Pro Arg
            20                  25                  30          
Pro Asp Asn Glu Thr Leu Trp Asp Lys Leu Asp His Tyr Tyr Arg Ile
        35                  40                  45              
Val Lys Ser Thr Leu Leu Leu Tyr Gln Ser Pro Thr Thr Gly Leu Phe
    50                  55                  60                  
Pro Thr Lys Thr Cys Gly Gly Asp Gln Lys Ala Lys Ile Gln Asp Ser
65                  70                  75                  80  
Leu Tyr Cys Ala Ala Gly Ala Trp Ala Leu Ala Leu Ala Tyr Arg Arg
                85                  90                  95      
Ile Asp Asp Asp Lys Gly Arg Thr His Glu Leu Glu His Ser Ala Ile
            100                 105                 110         
Lys Cys Met Arg Gly Ile Leu Tyr Cys Tyr Met Arg Gln Ala Asp Lys
        115                 120                 125             
Val Gln Gln Phe Lys Gln Asp Pro Arg Pro Thr Thr Cys Leu His Ser
    130                 135                 140                 
Val Phe Asn Val His Thr Gly Asp Glu Leu Leu Ser Tyr Glu Glu Tyr
145                 150                 155                 160 
Gly His Leu Gln Ile Asn Ala Val Ser Leu Tyr Leu Leu Tyr Leu Val
                165                 170                 175     
Glu Met Ile Ser Ser Gly Leu Gln Ile Ile Tyr Asn Thr Asp Glu Val
            180                 185                 190         
Ser Phe Ile Gln Asn Leu Val Phe Cys Val Glu Arg Val Tyr Arg Val
        195                 200                 205             
Pro Asp Phe Gly Val Trp Glu Arg Gly Ser Lys Tyr Asn Asn Gly Ser
    210                 215                 220                 
Thr Glu Leu His Ser Ser Ser Val Gly Leu Ala Lys Ala Ala Leu Glu
225                 230                 235                 240 
Ala Ile Asn Gly Phe Asn Leu Phe Gly Asn Gln Gly Cys Ser Trp Ser
                245                 250                 255     
Val Ile Phe Val Asp Leu Asp Ala His Asn Arg Asn Arg Gln Thr Leu
            260                 265                 270         
Cys Ser Leu Leu Pro Arg Glu Ser Arg Ser His Asn Thr Asp Ala Ala
        275                 280                 285             
Leu Leu Pro Cys Ile Ser Tyr Pro Ala Phe Ala Leu Asp Asp Glu Val
    290                 295                 300                 
Leu Phe Ser Gln Thr Leu Asp Lys Val Val Arg Lys Leu Lys Gly Lys
305                 310                 315                 320 
Tyr Gly Phe Lys Arg Phe Leu Arg Asp Gly Tyr Arg Thr Ser Leu Glu
                325                 330                 335     
Asp Pro Asn Arg Cys Tyr Tyr Lys Pro Ala Glu Ile Lys Leu Phe Asp
            340                 345                 350         
Gly Ile Glu Cys Glu Phe Pro Ile Phe Phe Leu Tyr Met Met Ile Asp
        355                 360                 365             
Gly Val Phe Arg Gly Asn Pro Lys Gln Val Gln Glu Tyr Gln Asp Leu
    370                 375                 380                 
Leu Thr Pro Val Leu His His Thr Thr Glu Gly Tyr Pro Val Val Pro
385                 390                 395                 400 
Lys Tyr Tyr Tyr Val Pro Ala Asp Phe Val Glu Tyr Glu Lys Asn Asn
                405                 410                 415     
Pro Gly Ser Gln Lys Arg Phe Pro Ser Asn Cys Gly Arg Asp Gly Lys
            420                 425                 430         
Leu Phe Leu Trp Gly Gln Ala Leu Tyr Ile Ile Ala Lys Leu Leu Ala
        435                 440                 445             
Asp Glu Leu Ile Ser Pro Lys Asp Ile Asp Pro Val Gln Arg Tyr Val
    450                 455                 460                 
Pro Leu Lys Asp Gln Arg Asn Val Ser Met Arg Phe Ser Asn Gln Gly
465                 470                 475                 480 
Pro Leu Glu Asn Asp Leu Val Val His Val Ala Leu Ile Ala Glu Ser
                485                 490                 495     
Gln Arg Leu Gln Val Phe Leu Asn Thr Tyr Gly Ile Gln Thr Gln Thr
            500                 505                 510         
Pro Gln Gln Val Glu Pro Ile Gln Ile Trp Pro Gln Gln Glu Leu Val
        515                 520                 525             
Lys Ala Tyr Leu Gln Leu Gly Ile Asn Glu Lys Leu Gly Leu Ser Gly
    530                 535                 540                 
Arg Pro Asp Arg Pro Ile Gly Cys Leu Gly Thr Ser Lys Ile Tyr Arg
545                 550                 555                 560 
Ile Leu Gly Lys Thr Val Val Cys Tyr Pro Ile Ile Phe Asp Leu Ser
                565                 570                 575     
Asp Phe Tyr Met Ser Gln Asp Val Phe Leu Leu Ile Asp Asp Ile Lys
            580                 585                 590         
Asn Ala Leu Gln Phe Ile Lys Gln Tyr Trp Lys Met His Gly Arg Pro
        595                 600                 605             
Leu Phe Leu Val Leu Ile Arg Glu Asp Asn Ile Arg Gly Ser Arg Phe
    610                 615                 620                 
Asn Pro Ile Leu Asp Met Leu Ala Ala Leu Lys Lys Gly Ile Ile Gly
625                 630                 635                 640 
Gly Val Lys Val His Val Asp Arg Leu Gln Thr Leu Ile Ser Gly Ala
                645                 650                 655     
Val Val Glu Gln Leu Asp Phe Leu Arg Ile Ser Asp Thr Glu Glu Leu
            660                 665                 670         
Pro Glu Phe Lys Ser Phe Glu Glu Leu Glu Pro Pro Lys His Ser Lys
        675                 680                 685             
Val Lys Arg Gln Ser Ser Thr Pro Ser Ala Pro Glu Leu Gly Gln Gln
    690                 695                 700                 
Pro Asp Val Asn Ile Ser Glu Trp Lys Asp Lys Pro Thr His Glu Ile
705                 710                 715                 720 
Leu Gln Lys Leu Asn Asp Cys Ser Cys Leu Ala Ser Gln Ala Ile Leu
                725                 730                 735     
Leu Gly Ile Leu Leu Lys Arg Glu Gly Pro Asn Phe Ile Thr Lys Glu
            740                 745                 750         
Gly Thr Val Ser Asp His Ile Glu Arg Val Tyr Arg Arg Ala Gly Ser
        755                 760                 765             
Gln Lys Leu Trp Ser Val Val Arg Arg Ala Ala Ser Leu Leu Ser Lys
    770                 775                 780                 
Val Val Asp Ser Leu Ala Pro Ser Ile Thr Asn Val Leu Val Gln Gly
785                 790                 795                 800 
Lys Gln Val Thr Leu Gly Ala Phe Gly His Glu Glu Glu Val Ile Ser
                805                 810                 815     
Asn Pro Leu Ser Pro Arg Val Ile Gln Asn Ile Ile Tyr Tyr Lys Cys
            820                 825                 830         
Asn Thr His Asp Glu Arg Glu Ala Val Ile Gln Gln Glu Leu Val Ile
        835                 840                 845             
His Ile Gly Trp Ile Ile Ser Asn Asn Pro Glu Leu Phe Ser Gly Met
    850                 855                 860                 
Leu Lys Ile Arg Ile Gly Trp Ile Ile His Ala Met Glu Tyr Glu Leu
865                 870                 875                 880 
Gln Ile Arg Gly Gly Asp Lys Pro Ala Leu Asp Leu Tyr Gln Leu Ser
                885                 890                 895     
Pro Ser Glu Val Lys Gln Leu Leu Leu Asp Ile Leu Gln Pro Gln Gln
            900                 905                 910         
Asn Gly Arg Cys Trp Leu Asn Arg Arg Gln Ile Asp Gly Ser Leu Asn
        915                 920                 925             
Arg Thr Pro Thr Gly Phe Tyr Asp Arg Val Trp Gln Ile Leu Glu Arg
    930                 935                 940                 
Thr Pro Asn Gly Ile Ile Val Ala Gly Lys His Leu Pro Gln Gln Pro
945                 950                 955                 960 
Thr Leu Ser Asp Met Thr Met Tyr Glu Met Asn Phe Ser Leu Leu Val
                965                 970                 975     
Glu Asp Thr Leu Gly Asn Ile Asp Gln Pro Gln Tyr Arg Gln Ile Val
            980                 985                 990         
Val Glu Leu Leu Met Val Val Ser Ile Val Leu Glu Arg Asn Pro Glu
        995                 1000                1005            
Leu Glu Phe Gln Asp Lys Val Asp Leu Asp Arg Leu Val Lys Glu Ala
    1010                1015                1020                
Phe Asn Glu Phe Gln Lys Asp Gln Ser Arg Leu Lys Glu Ile Glu Lys
1025                1030                1035                1040
Gln Asp Asp Met Thr Ser Phe Tyr Asn Thr Pro Pro Leu Gly Lys Arg
                1045                1050                1055    
Gly Thr Cys Ser Tyr Leu Thr Lys Ala Val Met Asn Leu Leu Leu Glu
            1060                1065                1070        
Gly Glu Val Lys Pro Asn Asn Asp Asp Pro Cys Leu Ile Ser
        1075                1080                1085    


<210> 5907
<211> 1235
<212> PRT
<213> Homo sapiens

<400> 5907
Met Arg Ser Arg Ser Asn Ser Gly Val Arg Leu Asp Gly Tyr Ala Arg
 1               5                  10                  15      
Leu Val Gln Gln Thr Ile Leu Cys Tyr Gln Asn Pro Val Thr Gly Leu
            20                  25                  30          
Leu Ser Ala Ser His Glu Gln Lys Asp Ala Trp Val Arg Asp Asn Ile
        35                  40                  45              
Tyr Ser Ile Leu Ala Val Trp Gly Leu Gly Met Ala Tyr Arg Lys Asn
    50                  55                  60                  
Ala Asp Arg Asp Glu Asp Lys Ala Lys Ala Tyr Glu Leu Glu Gln Asn
65                  70                  75                  80  
Val Val Lys Leu Met Arg Gly Leu Leu Gln Cys Met Met Arg Gln Val
                85                  90                  95      
Ala Lys Val Glu Lys Phe Lys His Thr Gln Ser Thr Lys Asp Ser Leu
            100                 105                 110         
His Ala Lys Tyr Asn Thr Ala Thr Cys Gly Thr Val Val Gly Asp Asp
        115                 120                 125             
Gln Trp Gly His Leu Gln Val Asp Ala Thr Ser Leu Phe Leu Leu Phe
    130                 135                 140                 
Leu Ala Gln Met Thr Ala Ser Gly Leu Arg Ile Ile Phe Thr Leu Asp
145                 150                 155                 160 
Glu Val Ala Phe Ile Gln Asn Leu Val Phe Tyr Ile Glu Ala Ala Tyr
                165                 170                 175     
Lys Val Ala Asp Tyr Gly Met Trp Glu Arg Gly Asp Lys Thr Asn Gln
            180                 185                 190         
Gly Ile Pro Glu Leu Asn Ala Ser Ser Val Gly Met Ala Lys Ala Ala
        195                 200                 205             
Leu Glu Ala Ile Asp Glu Leu Asp Leu Phe Gly Ala His Gly Gly Arg
    210                 215                 220                 
Lys Ser Val Ile His Val Leu Pro Asp Glu Val Glu His Cys Gln Ser
225                 230                 235                 240 
Ile Leu Phe Ser Met Leu Pro Arg Ala Ser Thr Ser Lys Glu Ile Asp
                245                 250                 255     
Ala Gly Leu Leu Ser Ile Ile Ser Phe Pro Ala Phe Ala Val Glu Asp
            260                 265                 270         
Val Asn Leu Val Asn Val Thr Lys Asn Glu Ile Ile Ser Lys Leu Gln
        275                 280                 285             
Gly Arg Tyr Gly Cys Cys Arg Phe Leu Arg Asp Gly Tyr Lys Thr Pro
    290                 295                 300                 
Arg Glu Asp Pro Asn Arg Leu His Tyr Asp Pro Ala Glu Leu Lys Leu
305                 310                 315                 320 
Phe Glu Asn Ile Glu Cys Glu Trp Pro Val Phe Trp Thr Tyr Phe Ile
                325                 330                 335     
Ile Asp Gly Val Phe Ser Gly Asp Ala Val Gln Val Gln Glu Tyr Arg
            340                 345                 350         
Glu Ala Leu Glu Gly Ile Leu Ile Arg Gly Lys Asn Gly Ile Arg Leu
        355                 360                 365             
Val Pro Glu Leu Tyr Ala Val Pro Pro Asn Lys Val Asp Glu Glu Tyr
    370                 375                 380                 
Lys Asn Pro His Thr Val Asp Arg Val Pro Met Gly Lys Val Pro His
385                 390                 395                 400 
Leu Trp Gly Gln Ser Leu Tyr Ile Leu Ser Ser Leu Leu Ala Glu Gly
                405                 410                 415     
Phe Leu Ala Ala Gly Glu Ile Asp Pro Leu Asn Arg Arg Phe Ser Thr
            420                 425                 430         
Ser Val Lys Pro Asp Val Val Val Gln Val Thr Val Leu Ala Glu Asn
        435                 440                 445             
Asn His Ile Lys Asp Leu Leu Arg Lys His Gly Val Asn Val Gln Ser
    450                 455                 460                 
Ile Ala Asp Ile His Pro Ile Gln Val Gln Pro Gly Arg Ile Leu Ser
465                 470                 475                 480 
His Ile Tyr Ala Lys Leu Gly Arg Asn Lys Asn Met Asn Leu Ser Gly
                485                 490                 495     
Arg Pro Tyr Arg His Ile Gly Val Leu Gly Thr Ser Lys Leu Tyr Val
            500                 505                 510         
Ile Arg Asn Gln Ile Phe Thr Phe Thr Pro Gln Phe Thr Asp Gln His
        515                 520                 525             
His Phe Tyr Leu Ala Leu Asp Asn Glu Met Ile Val Glu Met Leu Arg
    530                 535                 540                 
Ile Glu Leu Ala Tyr Leu Cys Thr Cys Trp Arg Met Thr Gly Arg Pro
545                 550                 555                 560 
Thr Leu Thr Phe Pro Ile Ser Arg Thr Met Leu Thr Asn Asp Gly Ser
                565                 570                 575     
Asp Ile His Ser Ala Val Leu Ser Thr Ile Arg Lys Leu Glu Asp Gly
            580                 585                 590         
Tyr Phe Gly Gly Ala Arg Val Lys Leu Gly Asn Leu Ser Glu Phe Leu
        595                 600                 605             
Thr Thr Ser Phe Tyr Thr Tyr Leu Thr Phe Leu Asp Pro Asp Cys Asp
    610                 615                 620                 
Glu Lys Leu Phe Asp Asn Ala Ser Glu Gly Thr Phe Ser Pro Asp Ser
625                 630                 635                 640 
Asp Ser Asp Leu Val Gly Tyr Leu Glu Asp Thr Cys Asn Gln Glu Ser
                645                 650                 655     
Gln Asp Glu Leu Asp His Tyr Ile Asn His Leu Leu Gln Ser Thr Ser
            660                 665                 670         
Leu Arg Ser Tyr Leu Pro Pro Leu Cys Lys Asn Thr Glu Asp Arg His
        675                 680                 685             
Val Phe Ser Ala Ile His Ser Thr Arg Asp Ile Leu Ser Val Met Ala
    690                 695                 700                 
Lys Ala Lys Gly Leu Glu Val Pro Phe Val Pro Met Thr Leu Pro Thr
705                 710                 715                 720 
Lys Val Leu Ser Ala His Arg Lys Ser Leu Asn Leu Val Asp Ser Pro
                725                 730                 735     
Gln Pro Leu Leu Glu Lys Val Pro Glu Ser Asp Phe Gln Trp Pro Arg
            740                 745                 750         
Asp Asp His Gly Asp Val Asp Cys Glu Lys Leu Val Glu Gln Leu Lys
        755                 760                 765             
Asp Cys Ser Asn Leu Gln Asp Gln Ala Asp Ile Leu Tyr Ile Leu Tyr
    770                 775                 780                 
Val Ile Lys Gly Pro Ser Trp Asp Thr Asn Leu Ser Gly Gln His Gly
785                 790                 795                 800 
Val Thr Val Gln Asn Leu Leu Gly Glu Leu Tyr Gly Lys Ala Gly Leu
                805                 810                 815     
Asn Gln Glu Trp Gly Leu Ile Arg Tyr Ile Ser Gly Leu Leu Arg Lys
            820                 825                 830         
Lys Val Glu Val Leu Ala Glu Ala Cys Thr Asp Leu Leu Ser His Gln
        835                 840                 845             
Lys Gln Leu Thr Val Gly Leu Pro Pro Glu Pro Arg Glu Lys Ile Ile
    850                 855                 860                 
Ser Ala Pro Leu Pro Pro Glu Glu Leu Thr Lys Leu Ile Tyr Glu Ala
865                 870                 875                 880 
Ser Gly Gln Asp Ile Ser Ile Ala Val Leu Thr Gln Glu Ile Val Val
                885                 890                 895     
Tyr Leu Ala Met Tyr Val Arg Ala Gln Pro Ser Leu Phe Val Glu Met
            900                 905                 910         
Leu Arg Leu Arg Ile Gly Leu Ile Ile Gln Val Met Ala Thr Glu Leu
        915                 920                 925             
Ala Arg Ser Leu Asn Cys Ser Gly Glu Glu Ala Ser Glu Ser Leu Met
    930                 935                 940                 
Asn Leu Ser Pro Phe Asp Met Lys Asn Leu Leu His His Ile Leu Ser
945                 950                 955                 960 
Gly Lys Glu Phe Gly Val Glu Arg Ser Val Arg Pro Ile His Ser Ser
                965                 970                 975     
Thr Ser Ser Pro Thr Ile Ser Ile His Glu Val Gly His Thr Gly Val
            980                 985                 990         
Thr Lys Thr Glu Arg Ser Gly Ile Asn Arg Leu Arg Ser Glu Met Lys
        995                 1000                1005            
Gln Met Thr Arg Arg Phe Ser Ala Asp Glu Gln Phe Phe Ser Val Gly
    1010                1015                1020                
Gln Ala Ala Ser Ser Ser Ala His Ser Ser Lys Ser Ala Arg Ser Ser
1025                1030                1035                1040
Thr Pro Ser Ser Pro Thr Gly Thr Ser Ser Ser Asp Ser Gly Gly His
                1045                1050                1055    
His Ile Gly Trp Gly Glu Arg Gln Gly Gln Trp Leu Arg Arg Arg Arg
            1060                1065                1070        
Leu Asp Gly Ala Ile Asn Arg Val Pro Val Gly Phe Tyr Gln Arg Val
        1075                1080                1085            
Trp Lys Ile Leu Gln Lys Cys His Gly Leu Ser Ile Asp Gly Tyr Val
    1090                1095                1100                
Leu Pro Ser Ser Thr Thr Arg Glu Met Thr Pro His Glu Ile Lys Phe
1105                1110                1115                1120
Ala Val His Val Glu Ser Val Leu Asn Arg Val Pro Gln Pro Glu Tyr
                1125                1130                1135    
Arg Gln Leu Leu Val Glu Ala Ile Met Val Leu Thr Leu Leu Ser Asp
            1140                1145                1150        
Thr Glu Met Thr Ser Ile Gly Gly Ile Ile His Val Asp Gln Ile Val
        1155                1160                1165            
Gln Met Ala Ser Gln Leu Phe Leu Gln Asp Gln Val Ser Ile Gly Ala
    1170                1175                1180                
Met Asp Thr Leu Glu Lys Asp Gln Ala Thr Gly Ile Cys His Phe Phe
1185                1190                1195                1200
Tyr Asp Ser Ala Pro Ser Gly Ala Tyr Gly Thr Met Thr Tyr Leu Thr
                1205                1210                1215    
Arg Ala Val Ala Ser Tyr Leu Gln Glu Leu Leu Pro Asn Ser Gly Cys
            1220                1225                1230        
Gln Met Gln
        1235


<210> 5908
<211> 316
<212> PRT
<213> Homo sapiens

<400> 5908
Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys
 1               5                  10                  15      
Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp
            20                  25                  30          
His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe
        35                  40                  45              
Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu
    50                  55                  60                  
Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr
65                  70                  75                  80  
Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro
                85                  90                  95      
Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr
            100                 105                 110         
Thr Pro Asn Ala Gln Gly Thr Glu Thr Pro Ser Val Leu Gln Lys His
        115                 120                 125             
Thr Thr Glu Asn Val Ser Ala Thr Arg Thr Pro Pro Thr Pro Gln Lys
    130                 135                 140                 
Pro Thr Thr Val Asn Val Pro Ala Thr Ile Val Thr Pro Thr Pro Gln
145                 150                 155                 160 
Lys Pro Thr Thr Ile Asn Val Pro Ala Thr Gly Val Ser Ser Thr Pro
                165                 170                 175     
Gln Arg His Thr Ile Val Asn Val Ser Ala Thr Gly Thr Leu Pro Thr
            180                 185                 190         
Leu Gln Lys Pro Thr Arg Ala Asn Asp Ser Ala Thr Lys Ser Pro Ala
        195                 200                 205             
Ala Ala Gln Thr Ser Phe Ile Ser Lys Thr Leu Ser Thr Lys Thr Pro
    210                 215                 220                 
Ser Ala Ala Gln Asn Pro Met Met Thr Asn Ala Ser Ala Thr Gln Ala
225                 230                 235                 240 
Thr Leu Thr Ala Gln Lys Phe Thr Thr Ala Lys Val Ala Phe Thr Gln
                245                 250                 255     
Ser Pro Ser Ala Ala Pro Thr Arg Ser Thr Pro Val Ser Arg Thr Thr
            260                 265                 270         
Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser
        275                 280                 285             
Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly
    290                 295                 300                 
Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr
305                 310                 315     


<210> 5909
<211> 750
<212> PRT
<213> Homo sapiens

<400> 5909
Met Met Glu Glu Leu His Ser Leu Asp Pro Arg Arg Gln Glu Leu Leu
 1               5                  10                  15      
Glu Ala Arg Phe Thr Gly Val Gly Val Ser Lys Gly Pro Leu Asn Ser
            20                  25                  30          
Glu Ser Ser Asn Gln Ser Leu Cys Ser Val Gly Ser Leu Ser Asp Lys
        35                  40                  45              
Glu Val Glu Thr Pro Glu Lys Lys Gln Asn Asp Gln Arg Asn Arg Lys
    50                  55                  60                  
Arg Lys Ala Glu Pro Tyr Glu Thr Ser Gln Gly Lys Gly Thr Pro Arg
65                  70                  75                  80  
Gly His Lys Ile Ser Asp Tyr Phe Glu Phe Ala Gly Gly Ser Ala Pro
                85                  90                  95      
Gly Thr Ser Pro Gly Arg Ser Val Pro Pro Val Ala Arg Ser Ser Pro
            100                 105                 110         
Gln His Ser Leu Ser Asn Pro Leu Pro Arg Arg Val Glu Gln Pro Leu
        115                 120                 125             
Tyr Gly Leu Asp Gly Ser Ala Ala Lys Glu Ala Thr Glu Glu Gln Ser
    130                 135                 140                 
Ala Leu Pro Thr Leu Met Ser Val Met Leu Ala Lys Pro Arg Leu Asp
145                 150                 155                 160 
Thr Glu Gln Leu Ala Gln Arg Gly Ala Gly Leu Cys Phe Thr Phe Val
                165                 170                 175     
Ser Ala Gln Gln Asn Ser Pro Ser Ser Thr Gly Ser Gly Asn Thr Glu
            180                 185                 190         
His Ser Cys Ser Ser Gln Lys Gln Ile Ser Ile Gln His Arg Gln Thr
        195                 200                 205             
Gln Ser Asp Leu Thr Ile Glu Lys Ile Ser Ala Leu Glu Asn Ser Lys
    210                 215                 220                 
Asn Ser Asp Leu Glu Lys Lys Glu Gly Arg Ile Asp Asp Leu Leu Arg
225                 230                 235                 240 
Ala Asn Cys Asp Leu Arg Arg Gln Ile Asp Glu Gln Gln Lys Met Leu
                245                 250                 255     
Glu Lys Tyr Lys Glu Arg Leu Asn Arg Cys Val Thr Met Ser Lys Lys
            260                 265                 270         
Leu Leu Ile Glu Lys Ser Lys Gln Glu Lys Met Ala Cys Arg Asp Lys
        275                 280                 285             
Ser Met Gln Asp Arg Leu Arg Leu Gly His Phe Thr Thr Val Arg His
    290                 295                 300                 
Gly Ala Ser Phe Thr Glu Gln Trp Thr Asp Gly Tyr Ala Phe Gln Asn
305                 310                 315                 320 
Leu Ile Lys Gln Gln Glu Arg Ile Asn Ser Gln Arg Glu Glu Ile Glu
                325                 330                 335     
Arg Gln Arg Lys Met Leu Ala Lys Arg Lys Pro Pro Ala Met Gly Gln
            340                 345                 350         
Ala Pro Pro Ala Thr Asn Glu Gln Lys Gln Arg Lys Ser Lys Thr Asn
        355                 360                 365             
Gly Ala Glu Asn Glu Thr Leu Thr Leu Ala Glu Tyr His Glu Gln Glu
    370                 375                 380                 
Glu Ile Phe Lys Leu Arg Leu Gly His Leu Lys Lys Glu Glu Ala Glu
385                 390                 395                 400 
Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg Val Arg Asn Leu His Ile
                405                 410                 415     
Arg Glu Leu Lys Arg Ile His Asn Glu Asp Asn Ser Gln Phe Lys Asp
            420                 425                 430         
His Pro Thr Leu Asn Asp Arg Tyr Leu Leu Leu His Leu Leu Gly Arg
        435                 440                 445             
Gly Gly Phe Ser Glu Val Tyr Lys Ala Phe Asp Leu Thr Glu Gln Arg
    450                 455                 460                 
Tyr Val Ala Val Lys Ile His Gln Leu Asn Lys Asn Trp Arg Asp Glu
465                 470                 475                 480 
Lys Lys Glu Asn Tyr His Lys His Ala Cys Arg Glu Tyr Arg Ile His
                485                 490                 495     
Lys Glu Leu Asp His Pro Arg Ile Val Lys Leu Tyr Asp Tyr Phe Ser
            500                 505                 510         
Leu Asp Thr Asp Ser Phe Cys Thr Val Leu Glu Tyr Cys Glu Gly Asn
        515                 520                 525             
Asp Leu Asp Phe Tyr Leu Lys Gln His Lys Leu Met Ser Glu Lys Glu
    530                 535                 540                 
Ala Arg Ser Ile Ile Met Gln Ile Val Asn Ala Leu Lys Tyr Leu Asn
545                 550                 555                 560 
Glu Ile Lys Pro Pro Ile Ile His Tyr Asp Leu Lys Pro Gly Asn Ile
                565                 570                 575     
Leu Leu Val Asn Gly Thr Ala Cys Gly Glu Ile Lys Ile Thr Asp Phe
            580                 585                 590         
Gly Leu Ser Lys Ile Met Asp Asp Asp Ser Tyr Asn Ser Val Asp Gly
        595                 600                 605             
Met Glu Leu Thr Ser Gln Gly Ala Gly Thr Tyr Trp Tyr Leu Pro Pro
    610                 615                 620                 
Glu Cys Phe Val Val Gly Lys Glu Pro Pro Lys Ile Ser Asn Lys Val
625                 630                 635                 640 
Asp Val Trp Ser Val Gly Val Ile Phe Tyr Gln Cys Leu Tyr Gly Arg
                645                 650                 655     
Lys Pro Phe Gly His Asn Gln Ser Gln Gln Asp Ile Leu Gln Glu Asn
            660                 665                 670         
Thr Ile Leu Lys Ala Thr Glu Val Gln Phe Pro Pro Lys Pro Val Val
        675                 680                 685             
Thr Pro Glu Ala Lys Ala Phe Ile Arg Arg Cys Leu Ala Tyr Arg Lys
    690                 695                 700                 
Glu Asp Arg Ile Asp Val Gln Gln Leu Ala Cys Asp Pro Tyr Leu Leu
705                 710                 715                 720 
Pro His Ile Arg Lys Ser Val Ser Thr Ser Ser Pro Ala Gly Ala Ala
                725                 730                 735     
Ile Ala Ser Thr Ser Gly Ala Ser Asn Asn Ser Ser Ser Asn
            740                 745                 750 


<210> 5910
<211> 772
<212> PRT
<213> Homo sapiens

<400> 5910
Met Met Glu Glu Leu His Ser Leu Asp Pro Arg Arg Gln Glu Leu Leu
 1               5                  10                  15      
Glu Ala Arg Phe Thr Gly Val Gly Val Ser Lys Gly Pro Leu Asn Ser
            20                  25                  30          
Glu Ser Ser Asn Gln Ser Leu Cys Ser Val Gly Ser Leu Ser Asp Lys
        35                  40                  45              
Glu Val Glu Thr Pro Glu Lys Lys Gln Asn Asp Gln Arg Asn Arg Lys
    50                  55                  60                  
Arg Lys Ala Glu Pro Tyr Glu Thr Ser Gln Gly Lys Gly Thr Pro Arg
65                  70                  75                  80  
Gly His Lys Ile Ser Asp Tyr Phe Glu Phe Ala Gly Gly Ser Ala Pro
                85                  90                  95      
Gly Thr Ser Pro Gly Arg Ser Val Pro Pro Val Ala Arg Ser Ser Pro
            100                 105                 110         
Gln His Ser Leu Ser Asn Pro Leu Pro Arg Arg Val Glu Gln Pro Leu
        115                 120                 125             
Tyr Gly Leu Asp Gly Ser Ala Ala Lys Glu Ala Thr Glu Glu Gln Ser
    130                 135                 140                 
Ala Leu Pro Thr Leu Met Ser Val Met Leu Ala Lys Pro Arg Leu Asp
145                 150                 155                 160 
Thr Glu Gln Leu Ala Gln Arg Gly Ala Gly Leu Cys Phe Thr Phe Val
                165                 170                 175     
Ser Ala Gln Gln Asn Ser Pro Ser Ser Thr Gly Ser Gly Asn Thr Glu
            180                 185                 190         
His Ser Cys Ser Ser Gln Lys Gln Ile Ser Ile Gln His Arg Gln Thr
        195                 200                 205             
Gln Ser Asp Leu Thr Ile Glu Lys Ile Ser Ala Leu Glu Asn Ser Lys
    210                 215                 220                 
Asn Ser Asp Leu Glu Lys Lys Glu Gly Arg Ile Asp Asp Leu Leu Arg
225                 230                 235                 240 
Ala Asn Cys Asp Leu Arg Arg Gln Ile Asp Glu Gln Gln Lys Met Leu
                245                 250                 255     
Glu Lys Tyr Lys Glu Arg Leu Asn Arg Cys Val Thr Met Ser Lys Lys
            260                 265                 270         
Leu Leu Ile Glu Lys Ser Lys Gln Glu Lys Met Ala Cys Arg Asp Lys
        275                 280                 285             
Ser Met Gln Asp Arg Leu Arg Leu Gly His Phe Thr Thr Val Arg His
    290                 295                 300                 
Gly Ala Ser Phe Thr Glu Gln Trp Thr Asp Gly Tyr Ala Phe Gln Asn
305                 310                 315                 320 
Leu Ile Lys Gln Gln Glu Arg Ile Asn Ser Gln Arg Glu Glu Ile Glu
                325                 330                 335     
Arg Gln Arg Lys Met Leu Ala Lys Arg Lys Pro Pro Ala Met Gly Gln
            340                 345                 350         
Ala Pro Pro Ala Thr Asn Glu Gln Lys Gln Arg Lys Ser Lys Thr Asn
        355                 360                 365             
Gly Ala Glu Asn Glu Thr Pro Ser Ser Gly Asn Thr Glu Leu Lys Asp
    370                 375                 380                 
Thr Ala Pro Ala Leu Gly Ala His Ser Leu Leu Arg Leu Thr Leu Ala
385                 390                 395                 400 
Glu Tyr His Glu Gln Glu Glu Ile Phe Lys Leu Arg Leu Gly His Leu
                405                 410                 415     
Lys Lys Glu Glu Ala Glu Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg
            420                 425                 430         
Val Arg Asn Leu His Ile Arg Glu Leu Lys Arg Ile His Asn Glu Asp
        435                 440                 445             
Asn Ser Gln Phe Lys Asp His Pro Thr Leu Asn Asp Arg Tyr Leu Leu
    450                 455                 460                 
Leu His Leu Leu Gly Arg Gly Gly Phe Ser Glu Val Tyr Lys Ala Phe
465                 470                 475                 480 
Asp Leu Thr Glu Gln Arg Tyr Val Ala Val Lys Ile His Gln Leu Asn
                485                 490                 495     
Lys Asn Trp Arg Asp Glu Lys Lys Glu Asn Tyr His Lys His Ala Cys
            500                 505                 510         
Arg Glu Tyr Arg Ile His Lys Glu Leu Asp His Pro Arg Ile Val Lys
        515                 520                 525             
Leu Tyr Asp Tyr Phe Ser Leu Asp Thr Asp Ser Phe Cys Thr Val Leu
    530                 535                 540                 
Glu Tyr Cys Glu Gly Asn Asp Leu Asp Phe Tyr Leu Lys Gln His Lys
545                 550                 555                 560 
Leu Met Ser Glu Lys Glu Ala Arg Ser Ile Ile Met Gln Ile Val Asn
                565                 570                 575     
Ala Leu Lys Tyr Leu Asn Glu Ile Lys Pro Pro Ile Ile His Tyr Asp
            580                 585                 590         
Leu Lys Pro Gly Asn Ile Leu Leu Val Asn Gly Thr Ala Cys Gly Glu
        595                 600                 605             
Ile Lys Ile Thr Asp Phe Gly Leu Ser Lys Ile Met Asp Asp Asp Ser
    610                 615                 620                 
Tyr Asn Ser Val Asp Gly Met Glu Leu Thr Ser Gln Gly Ala Gly Thr
625                 630                 635                 640 
Tyr Trp Tyr Leu Pro Pro Glu Cys Phe Val Val Gly Lys Glu Pro Pro
                645                 650                 655     
Lys Ile Ser Asn Lys Val Asp Val Trp Ser Val Gly Val Ile Phe Tyr
            660                 665                 670         
Gln Cys Leu Tyr Gly Arg Lys Pro Phe Gly His Asn Gln Ser Gln Gln
        675                 680                 685             
Asp Ile Leu Gln Glu Asn Thr Ile Leu Lys Ala Thr Glu Val Gln Phe
    690                 695                 700                 
Pro Pro Lys Pro Val Val Thr Pro Glu Ala Lys Ala Phe Ile Arg Arg
705                 710                 715                 720 
Cys Leu Ala Tyr Arg Lys Glu Asp Arg Ile Asp Val Gln Gln Leu Ala
                725                 730                 735     
Cys Asp Pro Tyr Leu Leu Pro His Ile Arg Lys Ser Val Ser Thr Ser
            740                 745                 750         
Ser Pro Ala Gly Ala Ala Ile Ala Ser Thr Ser Gly Ala Ser Asn Asn
        755                 760                 765             
Ser Ser Ser Asn
    770         


<210> 5911
<211> 750
<212> PRT
<213> Homo sapiens

<400> 5911
Met Met Glu Glu Leu His Ser Leu Asp Pro Arg Arg Gln Lys Leu Leu
 1               5                  10                  15      
Glu Ala Arg Phe Thr Gly Val Gly Val Ser Lys Gly Pro Leu Asn Ser
            20                  25                  30          
Glu Ser Ser Asn Gln Ser Leu Cys Ser Val Gly Ser Leu Ser Asp Lys
        35                  40                  45              
Glu Val Glu Thr Pro Lys Lys Lys Gln Asn Asp Gln Arg Asn Arg Lys
    50                  55                  60                  
Arg Lys Ala Glu Pro Tyr Glu Ser Ser Gln Gly Lys Gly Thr Pro Arg
65                  70                  75                  80  
Gly His Lys Ile Ser Asp Tyr Phe Glu Phe Ala Gly Gly Ser Gly Pro
                85                  90                  95      
Gly Thr Ser Pro Gly Arg Ser Val Pro Pro Val Ala Arg Ser Ser Leu
            100                 105                 110         
Gln His Ser Leu Ser Asn Pro Leu Pro Arg Arg Val Glu Gln Pro Leu
        115                 120                 125             
Tyr Gly Leu Asp Gly Ser Ala Ala Lys Glu Ala Thr Glu Glu Gln Ser
    130                 135                 140                 
Ala Leu Pro Thr Leu Met Ser Val Met Leu Ala Lys Pro Arg Leu Asp
145                 150                 155                 160 
Thr Glu Gln Leu Ala Gln Arg Gly Ala Gly Leu Cys Phe Thr Phe Val
                165                 170                 175     
Ser Ala Gln Gln Asn Ser Pro Ser Ser Thr Gly Ser Gly Asn Thr Glu
            180                 185                 190         
His Ser Cys Ser Ser Gln Lys Gln Ile Ser Ile Gln His Arg Gln Thr
        195                 200                 205             
Gln Ser Asp Leu Thr Ile Glu Lys Ile Ser Ala Leu Glu Asn Ser Lys
    210                 215                 220                 
Asn Ser Asp Leu Glu Lys Lys Glu Gly Arg Ile Asp Asp Leu Leu Arg
225                 230                 235                 240 
Ala Ile Cys Asp Leu Arg Arg Gln Ile Asp Glu Gln Gln Lys Met Leu
                245                 250                 255     
Glu Lys Tyr Lys Glu Arg Leu Asn Arg Cys Val Thr Met Ser Lys Lys
            260                 265                 270         
Leu Leu Ile Glu Lys Ser Lys Gln Glu Lys Met Ala Cys Arg Asp Lys
        275                 280                 285             
Ser Met Gln Asp Arg Leu Arg Leu Gly Tyr Phe Thr Thr Phe Arg His
    290                 295                 300                 
Gly Ala Lys Phe Thr Glu Gln Trp Thr Asp Gly Tyr Ala Phe Gln Asn
305                 310                 315                 320 
Leu Ile Lys Gln Gln Glu Arg Ile Asn Ser Gln Arg Glu Glu Ile Glu
                325                 330                 335     
Arg Gln Arg Lys Met Leu Ala Lys Arg Lys Pro Pro Ala Met Gly Gln
            340                 345                 350         
Ala Pro Pro Ala Thr Asn Glu Gln Lys Gln Trp Lys Ser Lys Thr Asn
        355                 360                 365             
Gly Ala Glu Asn Glu Thr Leu Thr Leu Lys Glu Tyr His Glu Gln Glu
    370                 375                 380                 
Glu Ile Phe Lys Leu Arg Leu Gly His Leu Lys Lys Glu Glu Ala Glu
385                 390                 395                 400 
Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg Val Arg Lys Leu His Ile
                405                 410                 415     
Arg Glu Val Lys Arg Ile His Asn Glu Asp Asn Ser Gln Phe Lys Tyr
            420                 425                 430         
His Pro Thr Leu Asn Asp Arg Tyr Leu Leu Leu His Leu Leu Gly Arg
        435                 440                 445             
Gly Gly Phe Ser Glu Val Tyr Lys Ala Phe Asp Leu Thr Glu Gln Arg
    450                 455                 460                 
Tyr Val Ala Val Lys Ile His Gln Leu Asn Lys Asn Trp Arg Asp Glu
465                 470                 475                 480 
Lys Lys Glu Asn Tyr His Lys His Ala Cys Arg Glu Tyr Arg Ile His
                485                 490                 495     
Lys Glu Leu Asp His Pro Arg Ile Val Lys Leu Tyr Asp Tyr Phe Ser
            500                 505                 510         
Leu Asp Thr Asp Ser Phe Cys Thr Val Leu Glu Tyr Cys Glu Gly Asn
        515                 520                 525             
Asp Leu Asp Phe Tyr Leu Lys Gln His Lys Leu Met Ser Glu Lys Glu
    530                 535                 540                 
Ala Arg Ser Ile Ile Met Gln Ile Val Asn Ala Leu Lys Tyr Leu Asn
545                 550                 555                 560 
Glu Ile Lys Pro Pro Ile Ile His Tyr Asp Leu Lys Pro Gly Asn Ile
                565                 570                 575     
Leu Leu Glu Asn Gly Thr Gly Cys Gly Glu Ile Lys Ile Thr Asp Phe
            580                 585                 590         
Gly Leu Ser Lys Ile Met Asp Asp Asp Ser Tyr Asn Ser Val Asp Gly
        595                 600                 605             
Met Glu Leu Thr Ser Gln Gly Ala Gly Thr Tyr Trp Tyr Leu Pro Pro
    610                 615                 620                 
Glu Cys Phe Val Val Gly Lys Glu Pro Pro Lys Ile Ser Asn Lys Val
625                 630                 635                 640 
Asp Val Trp Ser Val Gly Val Ile Phe Tyr Gln Cys Leu Tyr Gly Arg
                645                 650                 655     
Lys Pro Phe Gly His Asn Gln Ser Gln Gln Asp Ile Leu Gln Glu Asn
            660                 665                 670         
Thr Ile Leu Lys Ala Thr Glu Val Gln Phe Pro Pro Lys Pro Val Val
        675                 680                 685             
Thr Pro Glu Ala Lys Ala Leu Ile Arg Arg Cys Leu Ala Tyr Arg Lys
    690                 695                 700                 
Glu Asp Arg Ile Asp Val Gln Gln Leu Ala Cys Asp Pro Tyr Leu Leu
705                 710                 715                 720 
Pro His Ile Gln Lys Ser Val Ser Thr Ser Ser Pro Ala Gly Ala Ala
                725                 730                 735     
Ile Ala Ser Thr Ser Gly Ala Ser Asn Asn Ser Ser Ser Asn
            740                 745                 750 


<210> 5912
<211> 718
<212> PRT
<213> Homo sapiens

<400> 5912
Met Met Glu Glu Leu His Ser Leu Asp Pro Arg Arg Gln Glu Leu Leu
 1               5                  10                  15      
Glu Ala Arg Phe Thr Gly Val Gly Val Ser Lys Gly Pro Leu Asn Ser
            20                  25                  30          
Glu Ser Ser Asn Gln Ser Leu Cys Ser Val Gly Ser Leu Ser Asp Lys
        35                  40                  45              
Glu Val Glu Thr Pro Glu Lys Lys Gln Asn Asp Gln Arg Asn Arg Lys
    50                  55                  60                  
Arg Lys Ala Glu Pro Tyr Glu Thr Ser Gln Gly Lys Gly Thr Pro Arg
65                  70                  75                  80  
Gly His Lys Ile Ser Asp Tyr Phe Glu Arg Arg Val Glu Gln Pro Leu
                85                  90                  95      
Tyr Gly Leu Asp Gly Ser Ala Ala Lys Glu Ala Thr Glu Glu Gln Ser
            100                 105                 110         
Ala Leu Pro Thr Leu Met Ser Val Met Leu Ala Lys Pro Arg Leu Asp
        115                 120                 125             
Thr Glu Gln Leu Ala Gln Arg Gly Ala Gly Leu Cys Phe Thr Phe Val
    130                 135                 140                 
Ser Ala Gln Gln Asn Ser Pro Ser Ser Thr Gly Ser Gly Asn Thr Glu
145                 150                 155                 160 
His Ser Cys Ser Ser Gln Lys Gln Ile Ser Ile Gln His Arg Gln Thr
                165                 170                 175     
Gln Ser Asp Leu Thr Ile Glu Lys Ile Ser Ala Leu Glu Asn Ser Lys
            180                 185                 190         
Asn Ser Asp Leu Glu Lys Lys Glu Gly Arg Ile Asp Asp Leu Leu Arg
        195                 200                 205             
Ala Asn Cys Asp Leu Arg Arg Gln Ile Asp Glu Gln Gln Lys Met Leu
    210                 215                 220                 
Glu Lys Tyr Lys Glu Arg Leu Asn Arg Cys Val Thr Met Ser Lys Lys
225                 230                 235                 240 
Leu Leu Ile Glu Lys Ser Lys Gln Glu Lys Met Ala Cys Arg Asp Lys
                245                 250                 255     
Ser Met Gln Asp Arg Leu Arg Leu Gly His Phe Thr Thr Val Arg His
            260                 265                 270         
Gly Ala Ser Phe Thr Glu Gln Trp Thr Asp Gly Tyr Ala Phe Gln Asn
        275                 280                 285             
Leu Ile Lys Gln Gln Glu Arg Ile Asn Ser Gln Arg Glu Glu Ile Glu
    290                 295                 300                 
Arg Gln Arg Lys Met Leu Ala Lys Arg Lys Pro Pro Ala Met Gly Gln
305                 310                 315                 320 
Ala Pro Pro Ala Thr Asn Glu Gln Lys Gln Arg Lys Ser Lys Thr Asn
                325                 330                 335     
Gly Ala Glu Asn Glu Thr Leu Thr Leu Ala Glu Tyr His Glu Gln Glu
            340                 345                 350         
Glu Ile Phe Lys Leu Arg Leu Gly His Leu Lys Lys Glu Glu Ala Glu
        355                 360                 365             
Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg Val Arg Asn Leu His Ile
    370                 375                 380                 
Arg Glu Leu Lys Arg Ile His Asn Glu Asp Asn Ser Gln Phe Lys Asp
385                 390                 395                 400 
His Pro Thr Leu Asn Asp Arg Tyr Leu Leu Leu His Leu Leu Gly Arg
                405                 410                 415     
Gly Gly Phe Ser Glu Val Tyr Lys Ala Phe Asp Leu Thr Glu Gln Arg
            420                 425                 430         
Tyr Val Ala Val Lys Ile His Gln Leu Asn Lys Asn Trp Arg Asp Glu
        435                 440                 445             
Lys Lys Glu Asn Tyr His Lys His Ala Cys Arg Glu Tyr Arg Ile His
    450                 455                 460                 
Lys Glu Leu Asp His Pro Arg Ile Val Lys Leu Tyr Asp Tyr Phe Ser
465                 470                 475                 480 
Leu Asp Thr Asp Ser Phe Cys Thr Val Leu Glu Tyr Cys Glu Gly Asn
                485                 490                 495     
Asp Leu Asp Phe Tyr Leu Lys Gln His Lys Leu Met Ser Glu Lys Glu
            500                 505                 510         
Ala Arg Ser Ile Ile Met Gln Ile Val Asn Ala Leu Lys Tyr Leu Asn
        515                 520                 525             
Glu Ile Lys Pro Pro Ile Ile His Tyr Asp Leu Lys Pro Gly Asn Ile
    530                 535                 540                 
Leu Leu Val Asn Gly Thr Ala Cys Gly Glu Ile Lys Ile Thr Asp Phe
545                 550                 555                 560 
Gly Leu Ser Lys Ile Met Asp Asp Asp Ser Tyr Asn Ser Val Asp Gly
                565                 570                 575     
Met Glu Leu Thr Ser Gln Gly Ala Gly Thr Tyr Trp Tyr Leu Pro Pro
            580                 585                 590         
Glu Cys Phe Val Val Gly Lys Glu Pro Pro Lys Ile Ser Asn Lys Val
        595                 600                 605             
Asp Val Trp Ser Val Gly Val Ile Phe Tyr Gln Cys Leu Tyr Gly Arg
    610                 615                 620                 
Lys Pro Phe Gly His Asn Gln Ser Gln Gln Asp Ile Leu Gln Glu Asn
625                 630                 635                 640 
Thr Ile Leu Lys Ala Thr Glu Val Gln Phe Pro Pro Lys Pro Val Val
                645                 650                 655     
Thr Pro Glu Ala Lys Ala Phe Ile Arg Arg Cys Leu Ala Tyr Arg Lys
            660                 665                 670         
Glu Asp Arg Ile Asp Val Gln Gln Leu Ala Cys Asp Pro Tyr Leu Leu
        675                 680                 685             
Pro His Ile Arg Lys Ser Val Ser Thr Ser Ser Pro Ala Gly Ala Ala
    690                 695                 700                 
Ile Ala Ser Thr Ser Gly Ala Ser Asn Asn Ser Ser Ser Asn
705                 710                 715             


<210> 5913
<211> 431
<212> PRT
<213> Homo sapiens

<400> 5913
Met Tyr Arg Thr Lys Val Gly Leu Lys Asp Arg Gln Gln Leu Tyr Lys
 1               5                  10                  15      
Leu Ile Ile Ser Gln Leu Leu Tyr Asp Gly Tyr Ile Ser Ile Ala Asn
            20                  25                  30          
Gly Leu Ile Asn Glu Ile Lys Pro Gln Ser Val Cys Ala Pro Ser Glu
        35                  40                  45              
Gln Leu Leu His Leu Ile Lys Leu Gly Met Glu Asn Asp Asp Thr Ala
    50                  55                  60                  
Val Gln Tyr Ala Ile Gly Arg Ser Asp Thr Val Ala Pro Gly Thr Gly
65                  70                  75                  80  
Ile Asp Leu Glu Phe Asp Ala Asp Val Gln Thr Met Ser Pro Glu Ala
                85                  90                  95      
Ser Glu Tyr Glu Thr Cys Tyr Val Thr Ser His Lys Gly Pro Cys Arg
            100                 105                 110         
Val Ala Thr Tyr Ser Arg Asp Gly Gln Leu Ile Ala Thr Gly Ser Ala
        115                 120                 125             
Asp Ala Ser Ile Lys Ile Leu Asp Thr Glu Arg Met Leu Ala Lys Ser
    130                 135                 140                 
Ala Met Pro Ile Glu Val Met Met Asn Glu Thr Ala Gln Gln Asn Met
145                 150                 155                 160 
Glu Asn His Pro Val Ile Arg Thr Leu Tyr Asp His Val Asp Glu Val
                165                 170                 175     
Thr Cys Leu Ala Phe His Pro Thr Glu Gln Ile Leu Ala Ser Gly Ser
            180                 185                 190         
Arg Asp Tyr Thr Leu Lys Leu Phe Asp Tyr Ser Lys Pro Ser Ala Lys
        195                 200                 205             
Arg Ala Phe Lys Tyr Ile Gln Glu Ala Glu Met Leu Arg Ser Ile Ser
    210                 215                 220                 
Phe His Pro Ser Gly Asp Phe Ile Leu Val Gly Thr Gln His Pro Thr
225                 230                 235                 240 
Leu Arg Leu Tyr Asp Ile Asn Thr Phe Gln Cys Phe Val Ser Cys Asn
                245                 250                 255     
Pro Gln Asp Gln His Thr Asp Ala Ile Cys Ser Val Asn Tyr Asn Ser
            260                 265                 270         
Ser Ala Asn Met Tyr Val Thr Gly Ser Lys Asp Gly Cys Ile Lys Leu
        275                 280                 285             
Trp Asp Gly Val Ser Asn Arg Cys Ile Thr Thr Phe Glu Lys Ala His
    290                 295                 300                 
Asp Gly Ala Glu Val Cys Ser Ala Ile Phe Ser Lys Asn Ser Lys Tyr
305                 310                 315                 320 
Ile Leu Ser Ser Gly Lys Asp Ser Val Ala Lys Leu Trp Glu Ile Ser
                325                 330                 335     
Thr Gly Arg Thr Leu Val Arg Tyr Thr Gly Ala Gly Leu Ser Gly Arg
            340                 345                 350         
Gln Val His Arg Thr Gln Ala Val Phe Asn His Thr Glu Asp Tyr Val
        355                 360                 365             
Leu Leu Pro Asp Glu Arg Thr Ile Ser Leu Cys Cys Trp Asp Ser Arg
    370                 375                 380                 
Thr Ala Glu Arg Arg Asn Leu Leu Ser Leu Gly His Asn Asn Ile Val
385                 390                 395                 400 
Arg Cys Ile Val His Ser Pro Thr Asn Pro Gly Phe Met Thr Cys Ser
                405                 410                 415     
Asp Asp Phe Arg Ala Arg Phe Trp Tyr Arg Arg Ser Thr Thr Asp
            420                 425                 430     


<210> 5914
<211> 508
<212> PRT
<213> Homo sapiens

<400> 5914
Met Glu Lys Gln Arg Gln Glu Glu Gln Arg Lys Arg Thr Glu Glu Glu
 1               5                  10                  15      
Arg Lys Arg Arg Ile Glu Gln Asp Met Leu Glu Lys Arg Lys Ile Gln
            20                  25                  30          
Arg Glu Leu Ala Lys Arg Ala Glu Gln Ile Glu Asp Ile Asn Asn Thr
        35                  40                  45              
Gly Thr Glu Ser Ala Ser Glu Glu Gly Asp Asp Ser Leu Leu Ile Thr
    50                  55                  60                  
Val Val Pro Val Lys Ser Tyr Lys Thr Ser Gly Lys Met Lys Lys Asn
65                  70                  75                  80  
Phe Glu Asp Leu Glu Lys Glu Arg Glu Glu Lys Glu Arg Ile Lys Tyr
                85                  90                  95      
Glu Glu Asp Lys Arg Ile Arg Tyr Glu Glu Gln Arg Pro Ser Leu Lys
            100                 105                 110         
Glu Ala Lys Cys Leu Ser Leu Val Met Val Asn Glu Asp Glu Glu Asn
        115                 120                 125             
Gln Asp Thr Ala Lys Ile Phe Lys Gly Tyr Arg Pro Gly Lys Leu Lys
    130                 135                 140                 
Leu Ser Phe Glu Glu Met Glu Arg Gln Arg Arg Glu Asp Glu Lys Arg
145                 150                 155                 160 
Lys Ala Glu Glu Glu Ala Arg Arg Arg Ile Glu Glu Glu Lys Lys Ala
                165                 170                 175     
Phe Ala Glu Ala Arg Arg Asn Met Val Val Asp Asp Asp Ser Pro Glu
            180                 185                 190         
Met Tyr Lys Thr Ile Ser Gln Glu Phe Leu Thr Pro Gly Lys Leu Glu
        195                 200                 205             
Ile Asn Phe Glu Glu Leu Leu Lys Gln Lys Met Glu Glu Glu Lys Arg
    210                 215                 220                 
Arg Thr Glu Glu Glu Arg Lys His Lys Leu Glu Met Glu Lys Gln Glu
225                 230                 235                 240 
Phe Glu Gln Leu Arg Gln Glu Met Gly Glu Glu Glu Glu Glu Asn Glu
                245                 250                 255     
Thr Phe Gly Leu Ser Arg Glu Tyr Glu Glu Leu Ile Lys Leu Lys Arg
            260                 265                 270         
Ser Gly Ser Ile Gln Ala Lys Asn Leu Lys Ser Lys Phe Glu Lys Ile
        275                 280                 285             
Gly Gln Leu Ser Glu Lys Glu Ile Gln Lys Lys Ile Glu Glu Glu Arg
    290                 295                 300                 
Ala Arg Arg Arg Ala Ile Asp Leu Glu Ile Lys Glu Arg Glu Ala Glu
305                 310                 315                 320 
Asn Phe His Glu Glu Asp Asp Val Asp Val Arg Pro Ala Arg Lys Ser
                325                 330                 335     
Glu Ala Pro Phe Thr His Lys Val Asn Met Lys Ala Arg Phe Glu Gln
            340                 345                 350         
Met Ala Lys Ala Arg Glu Glu Glu Glu Gln Arg Arg Ile Glu Glu Gln
        355                 360                 365             
Lys Leu Leu Arg Met Gln Phe Glu Gln Arg Glu Ile Asp Ala Ala Leu
    370                 375                 380                 
Gln Lys Lys Arg Glu Glu Glu Glu Glu Glu Glu Gly Ser Ile Met Asn
385                 390                 395                 400 
Gly Ser Thr Ala Glu Asp Glu Glu Gln Thr Arg Ser Gly Ala Pro Trp
                405                 410                 415     
Phe Lys Lys Pro Leu Lys Asn Thr Ser Val Val Asp Ser Glu Pro Val
            420                 425                 430         
Arg Phe Thr Val Lys Val Thr Gly Glu Pro Lys Pro Glu Ile Thr Trp
        435                 440                 445             
Trp Phe Glu Gly Glu Ile Leu Gln Asp Gly Glu Asp Tyr Gln Tyr Ile
    450                 455                 460                 
Glu Arg Gly Glu Thr Tyr Cys Leu Tyr Leu Pro Glu Thr Phe Pro Glu
465                 470                 475                 480 
Asp Gly Gly Glu Tyr Met Cys Lys Ala Val Asn Asn Lys Gly Ser Ala
                485                 490                 495     
Ala Ser Thr Cys Ile Leu Thr Ile Glu Ser Lys Asn
            500                 505             


<210> 5915
<211> 448
<212> PRT
<213> Homo sapiens

<400> 5915
Met Asp Asp Glu Ile Glu Ser Glu Ala Lys Lys Glu Ser Leu Ser Pro
 1               5                  10                  15      
Arg Lys Leu Lys Leu Thr Phe Glu Glu Leu Glu Arg Gln Arg Gln Glu
            20                  25                  30          
Asn Arg Lys Lys Gln Ala Glu Glu Glu Ala Arg Lys Arg Leu Glu Glu
        35                  40                  45              
Glu Lys Arg Ala Phe Glu Glu Ala Arg Arg Gln Met Val Asn Glu Asp
    50                  55                  60                  
Glu Glu Asn Gln Asp Thr Ala Lys Ile Phe Lys Gly Tyr Arg Pro Gly
65                  70                  75                  80  
Lys Leu Lys Leu Ser Phe Glu Glu Met Glu Arg Gln Arg Arg Glu Asp
                85                  90                  95      
Glu Lys Arg Lys Ala Glu Glu Glu Ala Arg Arg Arg Ile Glu Glu Glu
            100                 105                 110         
Lys Lys Ala Phe Ala Glu Ala Arg Arg Asn Met Val Val Asp Asp Asp
        115                 120                 125             
Ser Pro Glu Met Tyr Lys Thr Ile Ser Gln Glu Phe Leu Thr Pro Gly
    130                 135                 140                 
Lys Leu Glu Ile Asn Phe Glu Glu Leu Leu Lys Gln Lys Met Glu Glu
145                 150                 155                 160 
Glu Lys Arg Arg Thr Glu Glu Glu Arg Lys His Lys Leu Glu Met Glu
                165                 170                 175     
Lys Gln Glu Phe Glu Gln Leu Arg Gln Glu Met Gly Glu Glu Glu Glu
            180                 185                 190         
Glu Asn Glu Thr Phe Gly Leu Ser Lys Glu Tyr Glu Glu Leu Ile Lys
        195                 200                 205             
Leu Lys Arg Ser Gly Ser Ile Gln Ala Lys Asn Leu Lys Ser Lys Phe
    210                 215                 220                 
Glu Lys Ile Gly Gln Leu Ser Glu Lys Glu Ile Gln Lys Lys Ile Glu
225                 230                 235                 240 
Glu Glu Arg Ala Arg Arg Arg Ala Ile Asp Leu Glu Ile Lys Glu Arg
                245                 250                 255     
Glu Ala Glu Asn Phe His Glu Glu Asp Asp Val Asp Val Arg Pro Ala
            260                 265                 270         
Arg Lys Ser Glu Ala Pro Phe Thr His Lys Val Asn Met Lys Ala Arg
        275                 280                 285             
Phe Glu Gln Met Ala Lys Ala Arg Glu Glu Glu Glu Gln Arg Arg Ile
    290                 295                 300                 
Glu Glu Gln Lys Leu Leu Arg Met Gln Phe Glu Gln Arg Glu Ile Asp
305                 310                 315                 320 
Ala Ala Leu Gln Lys Lys Arg Glu Glu Glu Glu Glu Glu Glu Gly Ser
                325                 330                 335     
Ile Met Asn Gly Ser Thr Ala Glu Asp Glu Glu Gln Thr Arg Ser Gly
            340                 345                 350         
Ala Pro Trp Phe Lys Lys Pro Leu Lys Asn Thr Ser Val Val Asp Ser
        355                 360                 365             
Glu Pro Val Arg Phe Thr Val Lys Val Thr Gly Glu Pro Lys Pro Glu
    370                 375                 380                 
Ile Thr Trp Trp Phe Glu Gly Glu Ile Leu Gln Asp Gly Glu Asp Tyr
385                 390                 395                 400 
Gln Tyr Ile Glu Arg Gly Glu Thr Tyr Cys Leu Tyr Leu Pro Glu Thr
                405                 410                 415     
Phe Pro Glu Asp Gly Gly Glu Tyr Met Cys Lys Ala Val Asn Asn Lys
            420                 425                 430         
Gly Ser Ala Ala Ser Thr Cys Ile Leu Thr Ile Glu Thr Asp Asp Tyr
        435                 440                 445             


<210> 5916
<211> 1395
<212> PRT
<213> Homo sapiens

<400> 5916
Met Leu Leu Pro Leu Pro Pro Gln Ser Ser Lys Pro Val Pro Lys Lys
 1               5                  10                  15      
Ser Gln Ser Ser Lys Ile Val Pro Ser His His Asp Pro Ser Glu Lys
            20                  25                  30          
Thr Gly Glu Asn Cys Gln Thr Lys Ile Ser Pro Ser Ser Leu Gln Glu
        35                  40                  45              
Ser Pro Ser Ser Leu Gln Gly Ala Leu Lys Lys Arg Ser Ala Phe Glu
    50                  55                  60                  
Asp Leu Thr Asn Ala Ser Gln Cys Gln Pro Val Gln Pro Lys Lys Glu
65                  70                  75                  80  
Ala Asn Lys Glu Phe Val Lys Val Val Ser Lys Lys Ile Asn Arg Asn
                85                  90                  95      
Thr His Ala Leu Gly Leu Ala Lys Lys Asn Lys Arg Asn Leu Lys Trp
            100                 105                 110         
His Lys Leu Glu Val Thr Pro Val Val Ala Ser Thr Thr Val Val Pro
        115                 120                 125             
Asn Ile Met Glu Lys Pro Leu Ile Leu Asp Ile Ser Thr Thr Ser Lys
    130                 135                 140                 
Thr Pro Asn Thr Glu Glu Ala Ser Leu Phe Arg Lys Pro Leu Val Leu
145                 150                 155                 160 
Lys Glu Glu Pro Thr Ile Glu Asp Glu Thr Leu Ile Asn Lys Ser Leu
                165                 170                 175     
Ser Leu Lys Lys Cys Ser Asn His Glu Glu Val Ser Leu Leu Glu Lys
            180                 185                 190         
Leu Gln Pro Leu Gln Glu Glu Ser Asp Ser Asp Asp Ala Phe Val Ile
        195                 200                 205             
Glu Pro Met Thr Phe Lys Lys Thr His Lys Thr Glu Glu Ala Ala Ile
    210                 215                 220                 
Thr Lys Lys Thr Leu Ser Leu Lys Lys Lys Met Cys Ala Ser Gln Arg
225                 230                 235                 240 
Lys Gln Ser Cys Gln Glu Glu Ser Leu Ala Val Gln Asp Val Asn Met
                245                 250                 255     
Glu Glu Asp Ser Phe Phe Met Glu Ser Met Ser Phe Lys Lys Lys Pro
            260                 265                 270         
Lys Thr Glu Glu Ser Ile Pro Thr His Lys Leu Ser Ser Leu Lys Lys
        275                 280                 285             
Lys Cys Thr Ile Tyr Gly Lys Ile Cys His Phe Arg Lys Pro Pro Val
    290                 295                 300                 
Leu Gln Thr Thr Ile Cys Gly Ala Met Ser Ser Ile Lys Lys Pro Thr
305                 310                 315                 320 
Thr Glu Lys Glu Thr Leu Phe Gln Glu Leu Phe Val Leu Gln Glu Lys
                325                 330                 335     
His Thr Thr Glu His Glu Met Ser Ile Leu Lys Lys Ser Leu Ala Leu
            340                 345                 350         
Gln Lys Thr Asn Phe Lys Glu Asp Ser Leu Val Lys Glu Ser Leu Ala
        355                 360                 365             
Phe Lys Lys Lys Pro Ser Thr Glu Glu Ala Ile Met Met Pro Val Ile
    370                 375                 380                 
Leu Lys Glu Gln Cys Met Thr Glu Gly Lys Arg Ser Arg Leu Lys Pro
385                 390                 395                 400 
Leu Val Leu Gln Glu Ile Thr Ser Gly Glu Lys Ser Leu Ile Met Lys
                405                 410                 415     
Pro Leu Ser Ile Lys Glu Lys Pro Ser Thr Glu Lys Glu Ser Phe Ser
            420                 425                 430         
Gln Glu Pro Ser Ala Leu Gln Lys Lys His Thr Thr Gln Glu Glu Val
        435                 440                 445             
Ser Ile Leu Lys Glu Pro Ser Ser Leu Leu Lys Ser Pro Thr Glu Glu
    450                 455                 460                 
Ser Pro Phe Asp Glu Ala Leu Ala Phe Thr Lys Lys Cys Thr Ile Glu
465                 470                 475                 480 
Glu Ala Pro Pro Thr Lys Lys Pro Leu Ile Leu Lys Arg Lys His Ala
                485                 490                 495     
Thr Gln Gly Thr Met Ser His Leu Lys Lys Pro Leu Ile Leu Gln Thr
            500                 505                 510         
Thr Ser Gly Glu Lys Ser Leu Ile Lys Glu Pro Leu Pro Phe Lys Glu
        515                 520                 525             
Glu Lys Val Ser Leu Lys Lys Lys Cys Thr Thr Gln Glu Met Met Ser
    530                 535                 540                 
Ile Cys Pro Glu Leu Leu Asp Phe Gln Asp Met Ile Gly Glu Asp Lys
545                 550                 555                 560 
Asn Ser Phe Phe Met Glu Pro Met Ser Phe Arg Lys Asn Pro Thr Thr
                565                 570                 575     
Glu Glu Thr Val Leu Thr Lys Thr Ser Leu Ser Leu Gln Glu Lys Lys
            580                 585                 590         
Ile Thr Gln Gly Lys Met Ser His Leu Lys Lys Pro Leu Val Leu Gln
        595                 600                 605             
Lys Ile Thr Ser Glu Glu Glu Ser Phe Tyr Lys Lys Leu Leu Pro Phe
    610                 615                 620                 
Lys Met Lys Ser Thr Thr Glu Glu Lys Phe Leu Ser Gln Glu Pro Ser
625                 630                 635                 640 
Ala Leu Lys Glu Lys His Thr Thr Leu Gln Glu Val Ser Leu Ser Lys
                645                 650                 655     
Glu Ser Leu Ala Ile Gln Glu Lys Ala Thr Thr Glu Glu Glu Phe Ser
            660                 665                 670         
Gln Glu Leu Phe Ser Leu His Val Lys His Thr Asn Lys Ser Gly Ser
        675                 680                 685             
Leu Phe Gln Glu Ala Leu Val Leu Gln Glu Lys Thr Asp Ala Glu Glu
    690                 695                 700                 
Asp Ser Leu Lys Asn Leu Leu Ala Leu Gln Glu Lys Ser Thr Met Glu
705                 710                 715                 720 
Glu Glu Ser Leu Ile Asn Lys Leu Leu Ala Leu Lys Glu Glu Leu Ser
                725                 730                 735     
Ala Glu Ala Ala Thr Asn Ile Gln Thr Gln Leu Ser Leu Lys Lys Lys
            740                 745                 750         
Ser Thr Ser His Gly Lys Val Phe Phe Leu Lys Lys Gln Leu Ala Leu
        755                 760                 765             
Asn Glu Thr Ile Asn Lys Glu Glu Phe Leu Asn Lys Gln Pro Leu Ala
    770                 775                 780                 
Leu Glu Gly Tyr Pro Ser Ile Ala Glu Gly Glu Thr Leu Phe Lys Lys
785                 790                 795                 800 
Leu Leu Ala Met Gln Glu Glu Pro Ser Ile Glu Lys Glu Ala Val Leu
                805                 810                 815     
Lys Glu Pro Thr Ile Asp Thr Glu Ala His Phe Lys Glu Pro Leu Ala
            820                 825                 830         
Leu Gln Glu Glu Pro Ser Thr Glu Lys Glu Ala Val Leu Lys Glu Pro
        835                 840                 845             
Ser Val Asp Thr Glu Ala His Phe Lys Glu Thr Leu Ala Leu Gln Glu
    850                 855                 860                 
Lys Pro Ser Ile Glu Gln Glu Ala Leu Phe Lys Arg His Ser Ala Leu
865                 870                 875                 880 
Trp Glu Lys Pro Ser Thr Glu Lys Glu Thr Ile Phe Lys Glu Ser Leu
                885                 890                 895     
Asp Leu Gln Glu Lys Pro Ser Ile Lys Lys Glu Thr Leu Leu Lys Lys
            900                 905                 910         
Pro Leu Ala Leu Lys Met Ser Thr Ile Asn Glu Ala Val Leu Phe Glu
        915                 920                 925             
Asp Met Ile Ala Leu Asn Glu Lys Pro Thr Thr Gly Lys Glu Leu Ser
    930                 935                 940                 
Phe Lys Glu Pro Leu Ala Leu Gln Glu Ser Pro Thr Tyr Lys Glu Asp
945                 950                 955                 960 
Thr Phe Leu Lys Thr Leu Leu Val Pro Gln Val Gly Thr Ser Pro Asn
                965                 970                 975     
Val Ser Ser Thr Ala Pro Glu Ser Ile Thr Ser Lys Ser Ser Ile Ala
            980                 985                 990         
Thr Met Thr Ser Val Gly Lys Ser Gly Thr Ile Asn Glu Ala Phe Leu
        995                 1000                1005            
Phe Glu Asp Met Ile Thr Leu Asn Glu Lys Pro Thr Thr Gly Lys Glu
    1010                1015                1020                
Leu Ser Phe Lys Glu Pro Leu Ala Leu Gln Glu Ser Pro Thr Cys Lys
1025                1030                1035                1040
Glu Asp Thr Phe Leu Glu Thr Phe Leu Ile Pro Gln Ile Gly Thr Ser
                1045                1050                1055    
Pro Tyr Val Phe Ser Thr Thr Pro Glu Ser Ile Thr Glu Lys Ser Ser
            1060                1065                1070        
Ile Ala Thr Met Thr Ser Val Gly Lys Ser Arg Thr Thr Thr Glu Ser
        1075                1080                1085            
Ser Ala Cys Glu Ser Ala Ser Asp Lys Pro Val Ser Pro Gln Ala Lys
    1090                1095                1100                
Gly Thr Pro Lys Glu Ile Thr Pro Arg Glu Asp Ile Asp Glu Asp Ser
1105                1110                1115                1120
Ser Asp Pro Ser Phe Asn Pro Met Tyr Ala Lys Glu Ile Phe Ser Tyr
                1125                1130                1135    
Met Lys Glu Arg Glu Glu Gln Phe Ile Leu Thr Asp Tyr Met Asn Arg
            1140                1145                1150        
Gln Ile Glu Ile Thr Ser Asp Met Arg Ala Ile Leu Val Asp Trp Leu
        1155                1160                1165            
Val Glu Val Gln Val Ser Phe Glu Met Thr His Glu Thr Leu Tyr Leu
    1170                1175                1180                
Ala Val Lys Leu Val Asp Leu Tyr Leu Met Lys Ala Val Cys Lys Lys
1185                1190                1195                1200
Asp Lys Leu Gln Leu Leu Gly Ala Thr Ala Phe Met Ile Ala Ala Lys
                1205                1210                1215    
Phe Glu Glu His Asn Ser Pro Arg Val Asp Asp Phe Val Tyr Ile Cys
            1220                1225                1230        
Asp Asp Asn Tyr Gln Arg Ser Glu Val Leu Ser Met Glu Ile Asn Ile
        1235                1240                1245            
Leu Asn Val Leu Lys Cys Asp Ile Asn Ile Pro Ile Ala Tyr His Phe
    1250                1255                1260                
Leu Arg Arg Tyr Ala Arg Cys Ile His Thr Asn Met Lys Thr Leu Thr
1265                1270                1275                1280
Leu Ser Arg Tyr Ile Cys Glu Met Thr Leu Gln Glu Tyr His Tyr Val
                1285                1290                1295    
Gln Glu Lys Ala Ser Lys Leu Ala Ala Ala Ser Leu Leu Leu Ala Leu
            1300                1305                1310        
Tyr Met Lys Lys Leu Gly Tyr Trp Val Pro Phe Leu Glu His Tyr Ser
        1315                1320                1325            
Gly Tyr Ser Ile Ser Glu Leu His Pro Leu Val Arg Gln Leu Asn Lys
    1330                1335                1340                
Leu Leu Thr Phe Ser Ser Tyr Asp Ser Leu Lys Ala Val Tyr Tyr Lys
1345                1350                1355                1360
Tyr Ser His Pro Val Phe Phe Glu Val Ala Lys Ile Pro Ala Leu Asp
                1365                1370                1375    
Met Leu Lys Leu Glu Glu Ile Leu Asn Cys Asp Cys Glu Ala Gln Gly
            1380                1385                1390        
Leu Val Leu
        1395


<210> 5917
<211> 387
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 332
<223> Xaa = Any Amino Acid

<400> 5917
Met Ala Thr Thr Gly Ser Ser Ser His Phe Pro Glu Val Tyr Lys Leu
 1               5                  10                  15      
Gln Asp Thr Gln Asp Ala Gln Met Leu Ser Thr Gly Asn Leu His Lys
            20                  25                  30          
Gln Leu Lys Val Asn Ser Gly Glu Lys Ile Asn Leu Gly Lys His Asp
        35                  40                  45              
Phe Phe Ser Ala Tyr Ala Cys Gly Ile Ile Glu Ile Ala Asp Phe Ser
    50                  55                  60                  
Met Pro Ala Phe Pro His Phe Leu Glu Asp His Gly Phe Lys Lys Val
65                  70                  75                  80  
Lys Pro Ser Leu Leu Cys Glu Asn Met Arg Leu Lys Cys Trp Arg Leu
                85                  90                  95      
Arg Ala Arg Glu Gln Pro Pro Leu Leu Arg Arg Trp Leu Leu Arg Arg
            100                 105                 110         
Gly Arg Cys Phe Val Thr Thr Thr Gln Val Ala Val Ser Glu Thr Ala
        115                 120                 125             
Asp Ala Ala Ala Leu Ala Leu Ser Gly Leu Arg Gly Ser Leu Asp Gly
    130                 135                 140                 
Leu Cys Gln Cys Pro Thr Leu Leu Phe Arg Thr Pro Arg Gln Ala Ala
145                 150                 155                 160 
Thr Leu Ser Gln Gln Pro Glu Arg Pro Glu Met Ala Ala Trp Thr Ala
                165                 170                 175     
Ser His Trp Pro Val Lys Gly Ile Leu Lys Asn Lys Thr Ser Thr Ala
            180                 185                 190         
Ser Ser Met Val Ala Ser Ala Glu Gln Pro Ser Gly Ser Val Glu Glu
        195                 200                 205             
Glu Leu Ser Lys Lys Ser Gln Lys Trp Glu Glu Met Asn Ile Leu Ala
    210                 215                 220                 
Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly Leu Met Lys Ile Val Glu
225                 230                 235                 240 
Pro Ser Thr Pro Ser Cys Arg Lys Met Gly Asp Gly Glu Asp Ala Cys
                245                 250                 255     
Ser Gly Ile Glu Thr Thr Glu Ala Val Ala Pro Asp Ile Leu Ala Lys
            260                 265                 270         
Lys Leu Ala Val Ala Glu Gly Leu Asn Pro Lys Tyr Arg Val Gln Glu
        275                 280                 285             
Gln Glu Ser Ser Gly Glu Glu Ala Ser Asp Leu Ser Pro Glu Glu Arg
    290                 295                 300                 
Glu Lys Arg Arg Gln Phe Gln Met Lys Arg Lys Leu His Tyr Asn Glu
305                 310                 315                 320 
Gly Leu Asn Ile Lys Leu Ala Arg Glu Leu Ile Xaa Lys Asp Leu His
                325                 330                 335     
Asp Asp Lys Asp Glu Glu Met Leu Lys Thr Ala Gly Gly Glu Ser Met
            340                 345                 350         
Lys Thr Glu Glu Ser Asn Gln Ser Ser Thr Thr Ser Asp Gln Arg Gln
        355                 360                 365             
Asn Thr Phe Ser Lys Phe Ile Glu Glu Leu Cys Ser Thr Leu Gln Leu
    370                 375                 380                 
Phe Ala Arg
385         


<210> 5918
<211> 1642
<212> PRT
<213> Homo sapiens

<400> 5918
Met Gly Ile Thr Lys Met Asn Met Asn Val Met Glu Glu Ala Ile Gly
 1               5                  10                  15      
Tyr Phe Glu Gln Gln Leu Ala Met Leu Gln Gln Leu Ser Gly Asn Glu
            20                  25                  30          
Ser Val Leu Asp Arg Gly Arg Ala Tyr Gly Asn Leu Gly Asp Cys Tyr
        35                  40                  45              
Glu Ala Leu Gly Asp Tyr Glu Glu Ala Ile Lys Tyr Tyr Glu Gln Tyr
    50                  55                  60                  
Leu Ser Val Ala Gln Ser Leu Asn Arg Met Gln Asp Gln Ala Lys Ala
65                  70                  75                  80  
Tyr Arg Gly Leu Gly Asn Gly His Arg Ala Met Gly Ser Leu Gln Gln
                85                  90                  95      
Ala Leu Val Cys Phe Glu Lys Arg Leu Val Val Ala His Glu Leu Gly
            100                 105                 110         
Glu Ala Phe Asn Lys Ala Gln Ala Tyr Gly Glu Leu Gly Ser Leu His
        115                 120                 125             
Ser Gln Leu Gly Asn Tyr Glu Gln Ala Ile Ser Cys Leu Glu Arg Gln
    130                 135                 140                 
Leu Asn Ile Ala Arg Asp Met Lys Asp Arg Ala Leu Glu Ser Asp Ala
145                 150                 155                 160 
Ala Cys Gly Leu Gly Gly Val Tyr Gln Gln Met Gly Glu Tyr Asp Thr
                165                 170                 175     
Ala Leu Gln Tyr His Gln Leu Asp Leu Gln Ile Ala Glu Glu Thr Asn
            180                 185                 190         
Asn Pro Thr Cys Gln Gly Arg Ala Tyr Gly Asn Leu Gly Leu Thr Tyr
        195                 200                 205             
Glu Ser Leu Gly Thr Phe Glu Arg Ala Val Val Tyr Gln Glu Gln His
    210                 215                 220                 
Leu Ser Ile Ala Ala Gln Met Asn Asp Leu Ala Ala Lys Thr Val Ser
225                 230                 235                 240 
Tyr Ser Ser Leu Gly Arg Thr His His Ala Leu Gln Asn Tyr Ser Gln
                245                 250                 255     
Ala Val Met Tyr Leu Gln Glu Gly Leu Arg Leu Ala Glu Gln Leu Gly
            260                 265                 270         
Arg Arg Glu Asp Glu Ala Lys Ile Arg His Gly Leu Gly Leu Ser Leu
        275                 280                 285             
Trp Ala Ser Gly Asn Leu Glu Glu Ala Gln His Gln Leu Tyr Arg Ala
    290                 295                 300                 
Ser Ala Leu Phe Glu Thr Ile Arg His Glu Ala Gln Leu Ser Thr Asp
305                 310                 315                 320 
Tyr Lys Leu Ser Leu Phe Asp Leu Gln Thr Ser Ser Tyr Gln Ala Leu
                325                 330                 335     
Gln Arg Val Leu Val Ser Leu Gly His His Asp Glu Ala Leu Ala Val
            340                 345                 350         
Ala Glu Arg Gly Arg Thr Arg Ala Phe Ala Asp Leu Leu Val Glu Arg
        355                 360                 365             
Gln Thr Gly Gln Gln Asp Ser Asp Pro Tyr Ser Pro Val Thr Ile Asp
    370                 375                 380                 
Gln Ile Leu Glu Met Val Asn Gly Gln Arg Gly Leu Val Leu Tyr Tyr
385                 390                 395                 400 
Ser Leu Ala Ala Gly Tyr Leu Tyr Ser Trp Leu Leu Ala Pro Gly Ala
                405                 410                 415     
Gly Ile Val Lys Phe His Glu His Tyr Leu Gly Glu Asn Thr Val Glu
            420                 425                 430         
Asn Ser Ser Asp Phe Gln Ala Ser Ser Ser Val Thr Leu Pro Thr Ala
        435                 440                 445             
Thr Gly Ser Ala Leu Glu Gln His Ile Ala Ser Val Arg Glu Ala Leu
    450                 455                 460                 
Gly Val Glu Ser His Tyr Ser Arg Ala Cys Ala Ser Ser Glu Thr Glu
465                 470                 475                 480 
Ser Glu Ala Gly Asp Ile Met Asp Gln Gln Phe Glu Glu Met Asn Asn
                485                 490                 495     
Lys Leu Asn Ser Val Thr Asp Pro Thr Gly Phe Leu Arg Met Val Arg
            500                 505                 510         
Arg Asn Asn Leu Phe Asn Arg Ser Cys Gln Ser Met Thr Ser Leu Phe
        515                 520                 525             
Ser Asn Thr Val Ser Pro Thr Gln Asp Gly Thr Ser Ser Leu Pro Arg
    530                 535                 540                 
Arg Gln Ser Ser Phe Ala Lys Pro Pro Leu Arg Ala Leu Tyr Asp Leu
545                 550                 555                 560 
Leu Ile Ala Pro Met Glu Gly Gly Leu Met His Ser Ser Gly Pro Val
                565                 570                 575     
Gly Arg His Arg Gln Leu Ile Leu Val Leu Glu Gly Glu Leu Tyr Leu
            580                 585                 590         
Ile Pro Phe Ala Leu Leu Lys Gly Ser Ser Ser Asn Glu Tyr Leu Tyr
        595                 600                 605             
Glu Arg Phe Gly Leu Leu Ala Val Pro Ser Ile Arg Ser Leu Ser Val
    610                 615                 620                 
Gln Ser Lys Ser His Leu Arg Lys Asn Pro Pro Thr Tyr Ser Ser Ser
625                 630                 635                 640 
Thr Ser Met Ala Ala Val Ile Gly Asn Pro Lys Leu Pro Ser Ala Val
                645                 650                 655     
Met Asp Arg Trp Leu Trp Gly Pro Met Pro Ser Ala Glu Glu Glu Ala
            660                 665                 670         
Tyr Met Val Ser Glu Leu Leu Gly Cys Gln Pro Leu Val Gly Ser Val
        675                 680                 685             
Ala Thr Lys Glu Arg Val Met Ser Ala Leu Thr Gln Ala Glu Cys Val
    690                 695                 700                 
His Phe Ala Thr His Ile Ser Trp Lys Leu Ser Ala Leu Val Leu Thr
705                 710                 715                 720 
Pro Ser Met Asp Gly Asn Pro Ala Ser Ser Lys Ser Ser Phe Gly His
                725                 730                 735     
Pro Tyr Thr Ile Pro Glu Ser Leu Arg Val Gln Asp Asp Ala Ser Asp
            740                 745                 750         
Gly Glu Ser Ile Ser Asp Cys Pro Pro Leu Gln Glu Leu Leu Leu Thr
        755                 760                 765             
Ala Ala Asp Val Leu Asp Leu Gln Leu Pro Val Lys Leu Val Val Leu
    770                 775                 780                 
Gly Ser Ser Gln Glu Ser Asn Ser Lys Val Thr Ala Asp Gly Val Ile
785                 790                 795                 800 
Ala Leu Thr Arg Ala Phe Leu Ala Ala Gly Ala Gln Cys Val Leu Val
                805                 810                 815     
Ser Leu Trp Pro Val Pro Val Ala Ala Ser Lys Met Phe Ile His Ala
            820                 825                 830         
Phe Tyr Ser Ser Leu Leu Asn Gly Leu Lys Ala Ser Ala Ala Leu Gly
        835                 840                 845             
Glu Ala Met Lys Val Val Gln Ser Ser Lys Ala Phe Ser His Pro Ser
    850                 855                 860                 
Asn Trp Ala Gly Phe Met Leu Ile Gly Ser Asp Val Lys Leu Asn Ser
865                 870                 875                 880 
Pro Ser Ser Leu Ile Gly Gln Ala Leu Thr Glu Ile Leu Gln His Pro
                885                 890                 895     
Glu Arg Ala Arg Asp Ala Leu Arg Val Leu Leu His Leu Val Glu Lys
            900                 905                 910         
Ser Leu Gln Arg Ile Gln Asn Gly Gln Arg Asn Ala Met Tyr Thr Ser
        915                 920                 925             
Gln Gln Ser Val Glu Asn Lys Val Gly Gly Ile Pro Gly Trp Gln Ala
    930                 935                 940                 
Leu Leu Thr Ala Val Gly Phe Arg Leu Asp Pro Pro Thr Ser Gly Leu
945                 950                 955                 960 
Pro Ala Ala Val Phe Phe Pro Thr Ser Asp Pro Gly Asp Arg Leu Gln
                965                 970                 975     
Gln Cys Ser Ser Thr Leu Gln Ser Leu Leu Gly Leu Pro Asn Pro Ala
            980                 985                 990         
Leu Gln Ala Leu Cys Lys Leu Ile Thr Ala Ser Glu Thr Gly Glu Gln
        995                 1000                1005            
Leu Ile Ser Arg Ala Val Lys Asn Met Val Gly Met Leu His Gln Val
    1010                1015                1020                
Leu Val Gln Leu Gln Ala Gly Glu Lys Glu Gln Asp Leu Ala Ser Ala
1025                1030                1035                1040
Pro Ile Gln Val Ser Ile Ser Val Gln Leu Trp Arg Leu Pro Gly Cys
                1045                1050                1055    
His Glu Phe Leu Ala Ala Leu Gly Phe Asp Leu Cys Glu Val Gly Gln
            1060                1065                1070        
Glu Glu Val Ile Leu Lys Thr Gly Lys Gln Ala Asn Arg Arg Thr Val
        1075                1080                1085            
His Phe Ala Leu Gln Ser Leu Leu Ser Leu Phe Asp Ser Thr Glu Leu
    1090                1095                1100                
Pro Lys Arg Leu Ser Leu Asp Ser Ser Ser Ser Leu Glu Ser Leu Ala
1105                1110                1115                1120
Ser Ala Gln Ser Val Ser Asn Ala Leu Pro Leu Gly Tyr Gln Gln Pro
                1125                1130                1135    
Pro Phe Ser Pro Thr Gly Ala Asp Ser Ile Ala Ser Asp Ala Ile Ser
            1140                1145                1150        
Val Tyr Ser Leu Ser Ser Ile Ala Ser Ser Met Ser Phe Val Ser Lys
        1155                1160                1165            
Pro Glu Gly Gly Ser Glu Gly Gly Gly Pro Gly Gly Arg Gln Asp His
    1170                1175                1180                
Asp Arg Ser Lys Asn Ala Tyr Leu Gln Arg Ser Thr Leu Pro Arg Ser
1185                1190                1195                1200
Gln Leu Pro Pro Gln Thr Arg Pro Ala Gly Asn Lys Asp Glu Glu Glu
                1205                1210                1215    
Tyr Glu Gly Phe Ser Ile Ile Ser Asn Glu Pro Leu Ala Thr Tyr Gln
            1220                1225                1230        
Glu Asn Arg Asn Thr Cys Phe Ser Pro Asp His Lys Gln Pro Gln Pro
        1235                1240                1245            
Gly Thr Ala Gly Gly Met Arg Val Ser Val Ser Ser Lys Gly Ser Ile
    1250                1255                1260                
Ser Thr Pro Asn Ser Pro Val Lys Met Thr Leu Ile Pro Ser Pro Asn
1265                1270                1275                1280
Ser Pro Phe Gln Lys Val Gly Lys Leu Ala Ser Ser Asp Thr Gly Glu
                1285                1290                1295    
Ser Asp Gln Ser Ser Thr Glu Thr Asp Ser Thr Val Lys Ser Gln Glu
            1300                1305                1310        
Glu Ser Asn Pro Lys Leu Asp Pro Gln Glu Leu Ala Gln Lys Ile Leu
        1315                1320                1325            
Glu Glu Thr Gln Ser His Leu Ile Ala Val Glu Arg Leu Gln Arg Ser
    1330                1335                1340                
Gly Gly Gln Val Ser Lys Ser Asn Asn Pro Glu Asp Gly Val Gln Ala
1345                1350                1355                1360
Pro Ser Ser Thr Ala Val Phe Arg Ala Ser Glu Thr Ser Ala Phe Ser
                1365                1370                1375    
Arg Pro Val Leu Ser His Gln Lys Ser Gln Pro Ser Pro Val Thr Val
            1380                1385                1390        
Lys Pro Lys Pro Pro Ala Arg Ser Ser Ser Leu Pro Lys Val Ser Ser
        1395                1400                1405            
Gly Tyr Ser Ser Pro Thr Thr Ser Glu Met Ser Ile Lys Asp Ser Pro
    1410                1415                1420                
Ser Gln His Ser Gly Arg Pro Ser Pro Gly Cys Asp Ser Gln Thr Ser
1425                1430                1435                1440
Gln Leu Asp Gln Pro Leu Phe Lys Leu Lys Tyr Pro Ser Ser Pro Tyr
                1445                1450                1455    
Ser Ala His Ile Ser Lys Ser Pro Arg Asn Met Ser Pro Ser Ser Gly
            1460                1465                1470        
His Gln Ser Pro Ala Gly Ser Ala Pro Ser Pro Ala Leu Ser Tyr Ser
        1475                1480                1485            
Ser Ala Gly Ser Ala Arg Ser Ser Pro Ala Asp Ala Pro Asp Ile Asp
    1490                1495                1500                
Lys Leu Lys Met Ala Ala Ile Asp Glu Lys Val Gln Ala Val His Asn
1505                1510                1515                1520
Leu Lys Met Phe Trp Gln Ser Thr Pro Gln His Ser Thr Gly Pro Met
                1525                1530                1535    
Lys Ile Phe Arg Gly Ala Pro Gly Thr Met Thr Ser Lys Arg Asp Val
            1540                1545                1550        
Leu Ser Leu Leu Asn Leu Ser Pro Arg His Asn Lys Lys Glu Glu Gly
        1555                1560                1565            
Val Asp Lys Leu Glu Leu Lys Glu Leu Ser Leu Gln Gln His Asp Gly
    1570                1575                1580                
Ala Pro Pro Lys Ala Pro Pro Asn Gly His Trp Arg Thr Glu Thr Thr
1585                1590                1595                1600
Ser Leu Gly Ser Leu Pro Leu Pro Ala Gly Pro Pro Ala Thr Ala Pro
                1605                1610                1615    
Ala Arg Pro Leu Arg Leu Pro Ser Gly Asn Gly Tyr Lys Phe Leu Ser
            1620                1625                1630        
Pro Gly Arg Phe Phe Pro Ser Ser Lys Cys
        1635                1640        


<210> 5919
<211> 1533
<212> PRT
<213> Homo sapiens

<400> 5919
Met Pro Val Lys Arg Leu Arg Glu Val Val Ser Gln Asn His Gly Asp
 1               5                  10                  15      
His Leu Val Leu Leu Lys Asp Glu Leu Pro Cys Val Pro Pro Ala Leu
            20                  25                  30          
Ser Ala Asn Lys Arg Leu Pro Val Gly Thr Gly Thr Ser Leu Asn Gly
        35                  40                  45              
Thr Ser Arg Gly Ser Ser Asp Leu Thr Ser Ala Arg Asn Cys Tyr Gln
    50                  55                  60                  
Pro Leu Leu Glu Asn Pro Met Val Ser Glu Ser Asp Phe Ser Lys Asp
65                  70                  75                  80  
Val Ala Val Gln Val Leu Pro Leu Asp Lys Ile Glu Glu Asn Asn Lys
                85                  90                  95      
Gln Lys Ala Asn Asp Ile Phe Ile Ser Gln Tyr Thr Met Gly Gln Lys
            100                 105                 110         
Asp Ala Leu Arg Thr Val Leu Lys Gln Lys Ala Gln Ser Met Pro Val
        115                 120                 125             
Phe Lys Glu Val Lys Val His Leu Leu Glu Asp Ala Gly Ile Glu Lys
    130                 135                 140                 
Asp Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser Gly Ile Asp Ser
145                 150                 155                 160 
Ala Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile Ala Thr Ala Ala
                165                 170                 175     
Pro Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys Val Asn Ser Val
            180                 185                 190         
Thr Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys His Leu Gln Arg
        195                 200                 205             
Val Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln Glu Lys Leu His
    210                 215                 220                 
Cys His Asp His Glu Lys Gln Met Asn Val Phe Met Glu Gln His Ile
225                 230                 235                 240 
Arg His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp Ile Gln Thr His
                245                 250                 255     
Phe Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln Pro Val Ser Met
            260                 265                 270         
Pro Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys Pro Glu His Pro
        275                 280                 285             
Asn Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr Phe Ala Ser Lys
    290                 295                 300                 
Gln Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe Asp Lys Gln Lys
305                 310                 315                 320 
Ser Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala Pro Val Pro Val
                325                 330                 335     
Ser Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu Leu Glu Glu Lys
            340                 345                 350         
Glu Asn Met Glu Val Ser Cys His Arg Gly Asn Val Arg Leu Leu Glu
        355                 360                 365             
Gln Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys Ser Glu Ser Ser
    370                 375                 380                 
Asn Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp Thr Pro Glu Lys
385                 390                 395                 400 
Thr Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr Thr Lys Val Thr
                405                 410                 415     
Met Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly Gln Lys Glu Lys
            420                 425                 430         
Glu Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu Ser Met Leu Lys
        435                 440                 445             
Leu Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln Thr Thr Asn Thr
    450                 455                 460                 
Thr Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu Arg Gly Val Gln
465                 470                 475                 480 
Asn Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala Ile Ile Arg Ala
                485                 490                 495     
Lys Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala Leu Ser Thr Asn
            500                 505                 510         
Arg Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr Val Asp Glu Trp
        515                 520                 525             
Ile Lys Thr Ile Ser Ala Glu Ile Gln Asp Glu Leu Ser Arg Thr Asp
    530                 535                 540                 
Tyr Glu Gln Lys Arg Phe Asp Gln Lys Asn Gln Arg Thr Lys Lys Gly
545                 550                 555                 560 
Gln Asn Met Thr Lys Asp Ile Arg Thr Asn Thr Gln Asp Lys Thr Val
                565                 570                 575     
Asn Lys Ser Val Ile Pro Arg Lys His Ser Gln Lys Gln Ile Glu Glu
            580                 585                 590         
His Phe Arg Asn Leu Pro Met Arg Gly Met Pro Ala Ser Ser Leu Gln
        595                 600                 605             
Lys Glu Arg Lys Glu Gly Leu Leu Lys Ala Thr Thr Val Ile Gln Asp
    610                 615                 620                 
Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val Tyr Gln Gly His
625                 630                 635                 640 
Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe Asn Ser Pro Ser
                645                 650                 655     
Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu Arg Val Lys Gly
            660                 665                 670         
Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe Tyr Ala Thr Lys
        675                 680                 685             
Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val Pro Val Leu Pro
    690                 695                 700                 
His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg Glu Met Pro Thr
705                 710                 715                 720 
Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met Ala Ile Leu Leu
                725                 730                 735     
Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro Ala Gly Val Ile
            740                 745                 750         
Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser Ile Pro Pro Ser
        755                 760                 765             
Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn Ile Ala Ile Val
    770                 775                 780                 
Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu Thr Val Gln Val
785                 790                 795                 800 
Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser Ser Ala Asp Val
                805                 810                 815     
Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Pro Pro Pro Val Gln
            820                 825                 830         
Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp Glu Glu Glu Val
        835                 840                 845             
Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp Val Ile Gln Glu
    850                 855                 860                 
Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro Ile Leu Glu Phe
865                 870                 875                 880 
Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn Gly Pro Pro Phe
                885                 890                 895     
Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp Ile Leu Asp Lys
            900                 905                 910         
Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu Ile Gln Trp Val
        915                 920                 925             
Glu Gln Glu Ile Met Ser Arg Ile Ile Ser Gly Leu Phe Pro Val Gln
    930                 935                 940                 
Gln Gln Ile Ala Pro Ser Ile Ser Val Ser Val Ser Glu Thr Ser Glu
945                 950                 955                 960 
Pro Leu Thr Ser Asp Ile Val Glu Gly Thr Ser Ser Gly Ala Leu Gln
                965                 970                 975     
Leu Phe Val Asp Ala Gly Val Pro Val Asn Ser Asn Val Ile Lys His
            980                 985                 990         
Phe Val Asn Glu Ala Leu Ala Glu Thr Ile Ala Val Met Leu Gly Asp
        995                 1000                1005            
Arg Glu Ala Lys Lys Gln Gly Pro Val Ala Thr Gly Val Ser Gly Asp
    1010                1015                1020                
Ala Ser Thr Asn Glu Thr Tyr Leu Pro Ala Arg Val Cys Thr Pro Leu
1025                1030                1035                1040
Ala Thr Pro Gln Pro Thr Pro Pro Cys Ser Pro Ser Ser Pro Ala Lys
                1045                1050                1055    
Glu Cys Val Leu Val Lys Thr Pro Asp Ser Ser Pro Cys Asp Ser Asp
            1060                1065                1070        
His Asp Met Ala Phe Pro Val Lys Glu Ile Cys Ala Glu Lys Gly Asp
        1075                1080                1085            
Asp Met Pro Ala Ile Met Leu Val Asn Thr Pro Thr Val Thr Pro Thr
    1090                1095                1100                
Thr Thr Pro Pro Pro Ala Ala Ala Val Phe Thr Pro Thr Leu Ser Asp
1105                1110                1115                1120
Ile Ser Ile Asp Lys Leu Lys Val Ser Ser Pro Glu Leu Pro Lys Pro
                1125                1130                1135    
Trp Gly Asp Gly Asp Leu Pro Leu Glu Glu Glu Asn Pro Asn Ser Pro
            1140                1145                1150        
Gln Glu Glu Leu His Pro Arg Ala Ile Val Met Ser Val Ala Lys Asp
        1155                1160                1165            
Glu Glu Pro Glu Ser Met Asp Phe Pro Ala Gln Pro Pro Pro Pro Glu
    1170                1175                1180                
Pro Val Pro Phe Met Pro Phe Pro Ala Gly Thr Lys Ala Pro Ser Pro
1185                1190                1195                1200
Ser Gln Met Pro Gly Ser Asp Ser Ser Thr Leu Glu Ser Thr Leu Ser
                1205                1210                1215    
Val Thr Val Thr Glu Thr Glu Thr Leu Asp Lys Pro Ile Ser Glu Gly
            1220                1225                1230        
Glu Ile Leu Phe Ser Cys Gly Gln Lys Leu Ala Pro Lys Ile Leu Glu
        1235                1240                1245            
Asp Ile Gly Leu Tyr Leu Thr Asn Leu Asn Asp Ser Leu Ser Ser Thr
    1250                1255                1260                
Leu His Asp Ala Val Glu Met Glu Asp Asp Pro Pro Ser Glu Gly Gln
1265                1270                1275                1280
Val Ile Arg Met Ser His Lys Lys Phe His Ala Asp Ala Ile Leu Ser
                1285                1290                1295    
Phe Ala Lys Gln Asn Gln Glu Ser Ala Val Ser Gln Gln Ala Val Tyr
            1300                1305                1310        
His Ser Glu Asp Leu Glu Asn Ser Val Gly Glu Leu Ser Glu Gly Gln
        1315                1320                1325            
Arg Pro Gln Leu Thr Ala Ala Ala Glu Asn Ile Leu Met Gly His Ser
    1330                1335                1340                
Leu Tyr Met Gln Pro Pro Val Thr Asn Thr Gln Ser Leu Asp Gln Gln
1345                1350                1355                1360
Cys Asp Pro Lys Pro Leu Ser Arg Gln Phe Asp Thr Val Ser Gly Ser
                1365                1370                1375    
Ile Tyr Glu Asp Ser Cys Ala Ser His Gly Pro Met Ser Leu Gly Glu
            1380                1385                1390        
Leu Glu Leu Glu Pro Asn Ser Lys Leu Val Leu Pro Thr Thr Leu Leu
        1395                1400                1405            
Thr Ala Gln Glu Asn Asp Val Asn Leu Pro Val Ala Ala Glu Asp Phe
    1410                1415                1420                
Ser Gln Tyr Gln Leu Lys Gln Asn Gln Asp Val Lys Gln Val Glu His
1425                1430                1435                1440
Lys Pro Ser Gln Ser Tyr Leu Arg Val Arg Asn Lys Ser Asp Ile Ala
                1445                1450                1455    
Pro Ser Gln Gln Gln Val Ser Pro Gly Asp Met Asp Arg Thr Gln Ile
            1460                1465                1470        
Glu Leu Asn Pro Tyr Leu Thr Cys Val Phe Ser Gly Gly Lys Ala Val
        1475                1480                1485            
Pro Leu Ser Ala Ser Gln Met Pro Pro Ala Lys Met Ser Val Met Leu
    1490                1495                1500                
Pro Ser Val Asn Leu Glu Asp Cys Ser Gln Ser Leu Ser Leu Ser Thr
1505                1510                1515                1520
Met Gln Glu Asp Met Glu Ser Ser Gly Ala Asp Thr Phe
                1525                1530            


<210> 5920
<211> 625
<212> PRT
<213> Homo sapiens

<400> 5920
Met Pro Arg Asn Lys Met Ser Phe Ser Ser Pro Gly Gln Gln Val Met
 1               5                  10                  15      
Tyr Pro Pro Gly Tyr Lys Thr Gln Gly His Gly Ala Glu Pro Ser Thr
            20                  25                  30          
Ser Pro Leu Ser Ser Ile Asn Tyr Ile Ile Gln Ser Thr Glu Thr Arg
        35                  40                  45              
Arg Ser Leu Asp Lys Leu Leu Lys Gly Asp Ile Asp Ile Gly Ser Gln
    50                  55                  60                  
Asn Gly Thr Asp Leu Phe Gly Phe Gly Asn Thr His Glu Tyr Pro Asp
65                  70                  75                  80  
Leu Gln Met Ile Leu Ser Gly Ala Leu Trp Cys Asn Ile His Lys Val
                85                  90                  95      
Ser Gly Lys Ala Cys Leu Ile Phe Pro His Arg Gly Tyr Asn Ser Ser
            100                 105                 110         
Lys Leu His Asn Arg Gly Ile Cys Leu Ser Leu Arg Ser Arg Ser Thr
        115                 120                 125             
Val Pro Leu Val Thr Arg Asn Ile Glu Pro Arg His Leu Cys Arg Gln
    130                 135                 140                 
Thr Leu Pro Ser Val Arg Ser Glu Leu Glu Cys Val Thr Asn Ile Thr
145                 150                 155                 160 
Leu Ala Asn Val Ile Arg Gln Leu Gly Ser Leu Ser Lys Tyr Ala Glu
                165                 170                 175     
Asp Ile Phe Gly Glu Leu Phe Thr Gln Ala Asn Thr Phe Ala Ser Pro
            180                 185                 190         
Val Ser Ser Leu Ala Glu Arg Val Asp Gly Leu Gln Val Lys Val Thr
        195                 200                 205             
Gln Leu Asp Pro Lys Glu Glu Glu Val Ser Leu Gln Val Ile Asn Thr
    210                 215                 220                 
Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Lys Leu Phe Asp
225                 230                 235                 240 
Arg Asn Ser Leu Pro Val Pro Val Leu Glu Thr Tyr Asn Thr Cys Asp
                245                 250                 255     
Thr Pro Pro Pro Leu Asn Asn Leu Thr Pro Tyr Arg Asp Asp Gly Thr
            260                 265                 270         
Glu Ala Leu Lys Phe Tyr Thr Asp Pro Ser Tyr Phe Phe Asp Leu Trp
        275                 280                 285             
Lys Lys Lys Met Leu Gln Asp Thr Arg Asp Ile Met Lys Glu Lys Arg
    290                 295                 300                 
Lys His Arg Lys Glu Lys Lys Asp Asn Pro Asn Arg Gly Asn Val Asn
305                 310                 315                 320 
Pro Arg Lys Ile Lys Thr Arg Lys Glu Glu Trp Glu Lys Ile Lys Met
                325                 330                 335     
Gly Gln Glu Phe Val Glu Ser Lys Glu Lys Leu Gly Pro Phe Gly Tyr
            340                 345                 350         
Pro Pro Thr Leu Val Tyr Gln Asn Gly Ser Ile Gly Cys Val Glu Asn
        355                 360                 365             
Val Asp Ala Ser Ser Tyr Pro Pro Pro Ser Gln Ser Asp Ser Ala Ser
    370                 375                 380                 
Ser Pro Ser Pro Ser Phe Ser Glu Asp Asn Leu Pro Pro Pro Pro Ala
385                 390                 395                 400 
Glu Phe Ser Tyr Pro Val Asp Asn Gln Arg Gly Ser Gly Leu Ala Gly
                405                 410                 415     
Pro Lys Arg Ser Ser Val Val Ser Pro Ser His Pro Pro Pro Ala Pro
            420                 425                 430         
Pro Leu Gly Ser Pro Pro Ser Ser Lys Pro Gly Phe Ala Pro Pro Pro
        435                 440                 445             
Ala Pro Pro Pro Pro Pro Pro Pro Met Ile Gly Ile Pro Pro Pro Pro
    450                 455                 460                 
Pro Pro Ile Gly Phe Gly Ser Pro Gly Thr Pro Pro Pro Pro Ser Ser
465                 470                 475                 480 
Pro Ser Phe Pro Pro His Pro Asp Phe Ala Ala Pro Pro Pro Leu Pro
                485                 490                 495     
Pro Pro Pro Ala Ala Asp Tyr Pro Thr Leu Pro Pro Pro Pro Leu Ser
            500                 505                 510         
Gln Pro Thr Arg Gly Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly
        515                 520                 525             
Pro Pro Pro Pro Pro Phe Thr Gly Ala Asp Gly Gln Pro Ala Val Pro
    530                 535                 540                 
Pro Pro Leu Ser Asp Thr Thr Lys Pro Lys Ser Ser Leu Pro Ala Ile
545                 550                 555                 560 
Ser Asp Ala His Ser Asp Leu Leu Ser Ala Ile Cys Gln Gly Phe Gln
                565                 570                 575     
Leu Arg Arg Val Glu Glu Gln Gln Glu Gln Glu Lys Trp Asp Val Val
            580                 585                 590         
Gly Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr
        595                 600                 605             
Ser Asp Ser Glu Asp Asp Ser Ser Glu Phe Asp Gly Asp Asp Trp Ser
    610                 615                 620                 
Asn
625 


<210> 5921
<211> 1187
<212> PRT
<213> Homo sapiens

<400> 5921
Met Arg Pro Arg Gly Ala Ala Phe Ala Ala Gly Pro Pro Gly Asp Leu
 1               5                  10                  15      
His Leu Gly Thr Ala Ile Gly Phe Ala Gly Ala Ile Trp Arg Ser Arg
            20                  25                  30          
Ser Pro Ala Met Ser Thr Leu Leu Asp Ile Lys Ser Ser Val Leu Arg
        35                  40                  45              
Gln Val Gln Val Cys Pro Ser Phe Arg Arg Arg Thr Glu Gln Asp Pro
    50                  55                  60                  
Gly Ser Ala Ser Ala Asp Pro Gln Glu Pro Ala Thr Gly Ala Trp Lys
65                  70                  75                  80  
Pro Gly Asp Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys
                85                  90                  95      
Lys Gly Glu Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg
            100                 105                 110         
Ser Gly Ser Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu
        115                 120                 125             
Arg Ala Leu Ala Pro Glu Glu Val Glu Met Leu Tyr Glu Glu Ala Leu
    130                 135                 140                 
Tyr Thr Val Leu Tyr Arg Ala Gly Thr Met Gly Pro Asp Gln Val Asp
145                 150                 155                 160 
Asp Glu Glu Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Thr Ser
                165                 170                 175     
Leu Glu Glu His Thr Glu Ala Ile Glu Arg Val Arg Lys Ala Lys Ala
            180                 185                 190         
Pro Thr Tyr Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu Leu
        195                 200                 205             
Ala Lys Asp Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly Ile
    210                 215                 220                 
Leu Pro Ala Ser Asp Ala Thr Arg Glu Pro Arg Ala Gln Lys Glu Gln
225                 230                 235                 240 
Arg Phe Gly Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro Ala
                245                 250                 255     
Lys Cys Ile Gln Val Thr Glu Val Lys Ser Ser Thr Leu Asn Pro Val
            260                 265                 270         
Trp Lys Glu His Phe Leu Phe Glu Ile Glu Asp Val Ser Thr Asp Gln
        275                 280                 285             
Leu His Leu Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val Glu
    290                 295                 300                 
Ala Cys Arg Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly Arg
305                 310                 315                 320 
Tyr Phe Lys Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Thr Ala Gly
                325                 330                 335     
Pro Thr Glu Asp His Thr Asp Asp Phe Leu Gly Cys Leu Asn Ile Pro
            340                 345                 350         
Val Arg Glu Val Pro Val Ala Gly Val Asp Arg Trp Phe Lys Leu Glu
        355                 360                 365             
Pro Arg Ser Ser Ala Ser Arg Val Gln Gly His Cys His Leu Val Leu
    370                 375                 380                 
Lys Leu Ile Thr Thr Gln Arg Asp Thr Ala Met Ser Gln Arg Gly Arg
385                 390                 395                 400 
Ser Gly Phe Leu Ser His Leu Leu Leu Leu Ser His Leu Leu Arg Leu
                405                 410                 415     
Glu His Ser Ala Glu Glu Pro Asn Ser Ser Ser Trp Arg Gly Glu Leu
            420                 425                 430         
Ser Thr Pro Ala Ala Thr Ile Leu Cys Leu His Gly Ala Gln Ser Asn
        435                 440                 445             
Leu Ser Pro Leu Gln Leu Ala Val Leu His Trp Gln Val Ser Ser Arg
    450                 455                 460                 
His His Gln Thr Cys Thr Leu Asp Tyr Ser Tyr Leu Leu Gly Leu Leu
465                 470                 475                 480 
Glu Asp Met Gln Ala His Trp Glu Glu Ala Pro Ser Leu Pro Gln Glu
                485                 490                 495     
Gln Glu Glu Ser Leu Ala Asp Ser Leu Ser Ala Phe Ser Glu Phe Gly
            500                 505                 510         
Leu Gln Leu Leu Arg Gln Leu Arg Asp Tyr Phe Pro Ala Thr Asn Ser
        515                 520                 525             
Thr Ala Val His Arg Leu Glu Leu Leu Leu Lys Cys Leu Gly Lys Leu
    530                 535                 540                 
Gln Leu Phe Gln Pro Ser Phe Glu Ile Cys Pro Phe Glu Ser Glu Leu
545                 550                 555                 560 
Asn Met Asp Ile Ala Ala Ala Leu Lys Arg Gly Asn Arg Glu Trp Tyr
                565                 570                 575     
Asp Arg Ile Leu Asn Asp Lys Ser Pro Arg Glu Gln Pro Gly Pro Gln
            580                 585                 590         
Arg Leu Pro Gly Leu Val Val Leu Ala Asp Ala Val Tyr Asp Asp Leu
        595                 600                 605             
Gln Phe Cys Tyr Ser Val Tyr Ala Ser Leu Phe His Ser Ile Leu Asn
    610                 615                 620                 
Val Asp Val Phe Thr Leu Thr Phe Arg Gln Leu Glu Arg Leu Val Ala
625                 630                 635                 640 
Glu Glu Ala Trp Val Leu Thr Glu Glu Leu Ser Pro Lys Met Thr Leu
                645                 650                 655     
Glu Val Ala Ser Gly Leu Phe Glu Leu Tyr Leu Thr Leu Ala Asp Leu
            660                 665                 670         
Gln Arg Phe Trp Asp Ser Ile Pro Gly Arg Asp Ser Arg Ser Leu Ala
        675                 680                 685             
Leu Ala Gly Ile His Ala Pro Phe Leu Pro Ala Val Lys Leu Trp Phe
    690                 695                 700                 
Gln Val Leu Arg Asp Gln Ala Lys Trp Arg Leu Gln Gly Ala Val Asp
705                 710                 715                 720 
Met Asp Thr Leu Glu Pro Val Asp Ala Ser Ser Arg His Ser Ser Ser
                725                 730                 735     
Ala Ala Thr Ala Gly Leu Cys Leu Ser His Ile Gln Glu Leu Trp Val
            740                 745                 750         
Arg Leu Ala Trp Pro Asp Pro Ala Gln Ala Gln Gly Leu Gly Thr Gln
        755                 760                 765             
Leu Gly Gln Asp Val Cys Glu Ala Thr Leu Phe Tyr Thr Glu Leu Leu
    770                 775                 780                 
Arg Lys Lys Val Asp Thr Gln Pro Gly Ala Ala Gly Glu Ala Val Ser
785                 790                 795                 800 
Glu Ala Leu Cys Val Val Leu Asn Asn Val Glu Leu Val Arg Lys Ala
                805                 810                 815     
Ala Gly Gln Ala Leu Lys Gly Leu Ala Trp Pro Glu Gly Ala Thr Gly
            820                 825                 830         
Pro Glu Gly Val Leu Pro Arg Pro Leu Leu Ser Cys Thr Gln Ala Leu
        835                 840                 845             
Asp Asp Asp Leu Gln Arg Glu Ala His Thr Val Thr Ala His Leu Thr
    850                 855                 860                 
Ser Lys Met Val Gly Asp Ile Arg Lys Tyr Val Gln His Ile Ser Leu
865                 870                 875                 880 
Ser Pro Asp Ser Ile Gln Asn Asp Glu Ala Val Ala Pro Leu Met Lys
                885                 890                 895     
Tyr Leu Asp Glu Lys Leu Ala Leu Leu Asn Ala Ser Leu Val Lys Gly
            900                 905                 910         
Asn Leu Ser Arg Val Leu Glu Ala Leu Trp Glu Leu Leu Leu Gln Ala
        915                 920                 925             
Ile Leu Gln Ala Leu Gly Ala Asn Arg Asp Val Ser Ala Asp Phe Tyr
    930                 935                 940                 
Ser Arg Phe His Phe Thr Leu Glu Ala Leu Val Ser Phe Phe His Ala
945                 950                 955                 960 
Glu Gly Gln Gly Leu Pro Leu Glu Ser Leu Arg Asp Gly Ser Tyr Lys
                965                 970                 975     
Arg Leu Lys Glu Glu Leu Arg Leu His Lys Cys Ser Thr Arg Glu Cys
            980                 985                 990         
Ile Glu Gln Phe Tyr Leu Asp Lys Leu Lys Gln Arg Thr Leu Glu Gln
        995                 1000                1005            
Asn Arg Phe Gly Arg Leu Ser Val Arg Cys His Tyr Glu Ala Ala Glu
    1010                1015                1020                
Gln Arg Leu Ala Val Glu Val Leu His Ala Ala Asp Leu Leu Pro Leu
1025                1030                1035                1040
Asp Ala Asn Gly Leu Ser Asp Pro Phe Val Ile Val Glu Leu Gly Pro
                1045                1050                1055    
Pro His Leu Phe Pro Leu Val Arg Ser Gln Arg Thr Gln Val Lys Thr
            1060                1065                1070        
Arg Thr Leu His Pro Val Tyr Asp Glu Leu Phe Tyr Phe Ser Val Pro
        1075                1080                1085            
Ala Glu Ala Cys Arg Arg Arg Ala Ala Cys Val Leu Phe Thr Val Met
    1090                1095                1100                
Asp His Asp Trp Leu Ser Thr Asn Asp Phe Ala Gly Glu Ala Ala Leu
1105                1110                1115                1120
Gly Leu Gly Gly Val Thr Gly Val Ala Arg Pro Gln Val Gly Gly Gly
                1125                1130                1135    
Ala Arg Ala Gly Gln Pro Val Thr Leu His Leu Cys Arg Pro Arg Ala
            1140                1145                1150        
Gln Val Arg Ser Ala Leu Arg Arg Leu Glu Gly Arg Thr Ser Lys Glu
        1155                1160                1165            
Ala Gln Glu Phe Val Lys Lys Leu Lys Glu Leu Glu Lys Cys Met Glu
    1170                1175                1180                
Ala Asp Pro
1185        


<210> 5922
<211> 1187
<212> PRT
<213> Homo sapiens

<400> 5922
Met Arg Pro Arg Gly Ala Ala Phe Ala Ala Gly Pro Pro Gly Asp Leu
 1               5                  10                  15      
His Leu Gly Thr Ala Ile Gly Phe Ala Gly Ala Ile Trp Arg Ser Arg
            20                  25                  30          
Ser Pro Ala Met Ser Thr Leu Leu Asp Ile Lys Ser Ser Val Leu Arg
        35                  40                  45              
Gln Val Gln Val Cys Pro Ser Phe Arg Arg Arg Thr Glu Gln Asp Pro
    50                  55                  60                  
Gly Ser Ala Ser Ala Asp Pro Gln Glu Pro Ala Thr Gly Ala Trp Lys
65                  70                  75                  80  
Pro Gly Asp Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys
                85                  90                  95      
Lys Gly Glu Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg
            100                 105                 110         
Ser Gly Ser Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu
        115                 120                 125             
Arg Ala Leu Ala Pro Glu Glu Val Glu Met Leu Tyr Glu Glu Ala Leu
    130                 135                 140                 
Tyr Thr Val Leu Tyr Arg Ala Gly Thr Met Gly Pro Asp Gln Val Asp
145                 150                 155                 160 
Asp Glu Glu Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Thr Ser
                165                 170                 175     
Leu Glu Glu His Thr Glu Ala Ile Glu Arg Val Arg Lys Ala Lys Ala
            180                 185                 190         
Pro Thr Tyr Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu Leu
        195                 200                 205             
Ala Lys Asp Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly Ile
    210                 215                 220                 
Leu Pro Ala Ser Asp Ala Thr Arg Glu Pro Arg Ala Gln Lys Glu Gln
225                 230                 235                 240 
Arg Phe Gly Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro Ala
                245                 250                 255     
Lys Cys Ile Gln Val Thr Glu Val Lys Ser Ser Thr Leu Asn Pro Val
            260                 265                 270         
Trp Lys Glu His Phe Leu Phe Glu Ile Glu Asp Val Ser Thr Asp Gln
        275                 280                 285             
Leu His Leu Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val Glu
    290                 295                 300                 
Ala Cys Arg Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly Arg
305                 310                 315                 320 
Tyr Phe Lys Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Thr Ala Gly
                325                 330                 335     
Pro Thr Glu Asp His Thr Asp Asp Phe Leu Gly Cys Leu Asn Ile Pro
            340                 345                 350         
Val Arg Glu Val Pro Val Ala Gly Val Asp Arg Trp Phe Lys Leu Glu
        355                 360                 365             
Pro Arg Ser Ser Ala Ser Arg Val Gln Gly His Cys His Leu Val Leu
    370                 375                 380                 
Lys Leu Ile Thr Thr Gln Arg Asp Thr Ala Met Ser Gln Arg Gly Arg
385                 390                 395                 400 
Ser Gly Phe Leu Ser His Leu Leu Leu Leu Ser His Leu Leu Arg Leu
                405                 410                 415     
Glu His Ser Ala Glu Glu Pro Asn Ser Ser Ser Trp Arg Gly Glu Leu
            420                 425                 430         
Ser Thr Pro Ala Ala Thr Ile Leu Cys Leu His Gly Ala Gln Ser Asn
        435                 440                 445             
Leu Ser Pro Leu Gln Leu Ala Val Leu His Trp Gln Val Ser Ser Arg
    450                 455                 460                 
His His Gln Thr Cys Thr Leu Asp Tyr Ser Tyr Leu Leu Gly Leu Leu
465                 470                 475                 480 
Glu Asp Met Gln Ala His Trp Glu Glu Ala Pro Ser Leu Pro Gln Glu
                485                 490                 495     
Gln Glu Glu Ser Leu Ala Asp Ser Leu Ser Ala Phe Ser Glu Phe Gly
            500                 505                 510         
Leu Gln Leu Leu Arg Gln Leu Arg Asp Tyr Phe Pro Ala Thr Asn Ser
        515                 520                 525             
Thr Ala Val His Arg Leu Glu Leu Leu Leu Lys Cys Leu Gly Lys Leu
    530                 535                 540                 
Gln Leu Phe Gln Pro Ser Phe Glu Ile Cys Pro Phe Glu Ser Glu Leu
545                 550                 555                 560 
Asn Met Asp Ile Ala Ala Ala Leu Lys Arg Gly Asn Arg Glu Trp Tyr
                565                 570                 575     
Asp Arg Ile Leu Asn Ala Lys Ser Pro Arg Glu Gln Pro Gly Pro Gln
            580                 585                 590         
Arg Leu Pro Gly Leu Val Val Leu Ala Asp Ala Val Tyr Asp Asp Leu
        595                 600                 605             
Gln Phe Cys Tyr Ser Val Tyr Ala Ser Leu Phe His Ser Ile Leu Asn
    610                 615                 620                 
Val Asp Val Phe Thr Leu Thr Phe Arg Gln Leu Glu Arg Leu Val Ala
625                 630                 635                 640 
Glu Glu Ala Trp Val Leu Thr Glu Glu Leu Ser Pro Lys Met Thr Leu
                645                 650                 655     
Glu Val Ala Ser Gly Leu Phe Glu Leu Tyr Leu Thr Leu Ala Asp Leu
            660                 665                 670         
Gln Arg Phe Trp Asp Ser Ile Pro Gly Arg Asp Ser Arg Ser Leu Ala
        675                 680                 685             
Leu Ala Gly Ile His Ala Pro Phe Leu Pro Ala Val Lys Leu Trp Phe
    690                 695                 700                 
Gln Val Leu Arg Asp Gln Ala Lys Trp Arg Leu Gln Gly Ala Val Asp
705                 710                 715                 720 
Met Asp Thr Leu Glu Pro Val Asp Ala Ser Ser Arg His Ser Ser Ser
                725                 730                 735     
Ala Ala Thr Ala Gly Leu Cys Leu Ser His Ile Gln Glu Leu Trp Val
            740                 745                 750         
Arg Leu Ala Trp Pro Asp Pro Ala Gln Ala Gln Gly Leu Gly Thr Gln
        755                 760                 765             
Leu Gly Gln Asp Val Cys Glu Ala Thr Leu Phe Tyr Thr Glu Leu Leu
    770                 775                 780                 
Arg Lys Lys Val Asp Thr Gln Pro Gly Ala Ala Gly Glu Ala Val Ser
785                 790                 795                 800 
Glu Ala Leu Cys Val Val Leu Asn Asn Val Glu Leu Val Arg Lys Ala
                805                 810                 815     
Ala Gly Gln Ala Leu Lys Gly Leu Ala Trp Pro Glu Gly Ala Thr Gly
            820                 825                 830         
Pro Glu Gly Val Leu Pro Arg Pro Leu Leu Ser Cys Thr Gln Ala Leu
        835                 840                 845             
Asp Asp Asp Leu Gln Arg Glu Ala His Thr Val Thr Ala His Leu Thr
    850                 855                 860                 
Ser Lys Met Val Gly Asp Ile Arg Lys Tyr Val Gln His Ile Ser Leu
865                 870                 875                 880 
Ser Pro Asp Ser Ile Gln Asn Asp Glu Ala Val Ala Pro Leu Met Lys
                885                 890                 895     
Tyr Leu Asp Glu Lys Leu Ala Leu Leu Asn Ala Ser Leu Val Lys Gly
            900                 905                 910         
Asn Leu Ser Arg Val Leu Glu Ala Leu Trp Glu Leu Leu Leu Gln Ala
        915                 920                 925             
Ile Leu Gln Ala Leu Gly Ala Asn Arg Asp Val Ser Ala Asp Phe Tyr
    930                 935                 940                 
Ser Arg Phe His Phe Thr Leu Glu Ala Leu Val Ser Phe Phe His Ala
945                 950                 955                 960 
Glu Gly Gln Gly Leu Pro Leu Glu Ser Leu Arg Asp Gly Ser Tyr Lys
                965                 970                 975     
Arg Leu Lys Glu Glu Leu Arg Leu His Lys Cys Ser Thr Arg Glu Cys
            980                 985                 990         
Ile Glu Gln Phe Tyr Leu Asp Lys Leu Lys Gln Arg Thr Leu Glu Gln
        995                 1000                1005            
Asn Arg Phe Gly Arg Leu Ser Val Arg Cys His Tyr Glu Ala Ala Glu
    1010                1015                1020                
Gln Arg Leu Ala Val Glu Val Leu His Ala Ala Asp Leu Leu Pro Leu
1025                1030                1035                1040
Asp Ala Asn Gly Leu Ser Asp Pro Phe Val Ile Val Glu Leu Gly Pro
                1045                1050                1055    
Pro His Leu Phe Pro Leu Val Arg Ser Gln Arg Thr Gln Val Lys Thr
            1060                1065                1070        
Arg Thr Leu His Pro Val Tyr Asp Glu Leu Phe Tyr Phe Ser Val Pro
        1075                1080                1085            
Ala Glu Ala Cys Arg Arg Arg Ala Ala Cys Val Leu Phe Thr Val Met
    1090                1095                1100                
Asp His Asp Trp Leu Ser Thr Asn Asp Phe Ala Gly Glu Ala Ala Leu
1105                1110                1115                1120
Gly Leu Gly Gly Val Thr Gly Val Ala Arg Pro Gln Val Gly Gly Gly
                1125                1130                1135    
Ala Arg Ala Gly Gln Pro Val Thr Leu His Leu Cys Arg Pro Arg Ala
            1140                1145                1150        
Gln Val Arg Ser Ala Leu Arg Arg Leu Glu Gly Arg Thr Ser Lys Glu
        1155                1160                1165            
Ala Gln Glu Phe Val Lys Lys Leu Lys Glu Leu Glu Lys Cys Met Glu
    1170                1175                1180                
Ala Asp Pro
1185        


<210> 5923
<211> 157
<212> PRT
<213> Homo sapiens

<400> 5923
Met Gly Gly Glu Gln Glu Glu Glu Arg Phe Asp Gly Met Leu Leu Ala
 1               5                  10                  15      
Met Ala Gln Gln His Glu Gly Gly Val Gln Glu Leu Val Asn Thr Phe
            20                  25                  30          
Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile Gly Gly Glu Glu
        35                  40                  45              
Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln
    50                  55                  60                  
Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu
65                  70                  75                  80  
Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys
                85                  90                  95      
Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala
            100                 105                 110         
Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His
        115                 120                 125             
Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Gln Gly Ser Arg Ile Leu
    130                 135                 140                 
Arg Lys Met Arg Arg Lys Met Arg Arg Thr Lys Glu Asn
145                 150                 155         


<210> 5924
<211> 546
<212> PRT
<213> Homo sapiens

<400> 5924
Met Ser Ser Ala Trp Lys Thr Pro Arg Gly Ser Asp Ala Met Pro Glu
 1               5                  10                  15      
Ile Met Val Lys Ile Ile Gly Ser Lys His Phe Gln Tyr Leu Val Glu
            20                  25                  30          
Lys Pro Lys Ile Lys Glu Asn Asp Ser Leu Lys Thr Glu Thr Gln Thr
        35                  40                  45              
Met His Gln Lys Pro Met Thr Asp Asn Ala Arg Gln Met Ser Arg Asp
    50                  55                  60                  
Thr Pro Val Pro Ile Asn Phe Thr Asp Gln Gln Thr Thr Asp Asn Pro
65                  70                  75                  80  
Asp Asp Val Lys Glu Lys Lys His Pro Glu Asn Asn Gln Lys Ser Glu
                85                  90                  95      
Asn Asn Gln Lys Leu Leu Thr Gly Ala Asn Ser Ser Arg Phe Leu Asp
            100                 105                 110         
Gly Asn Ile Pro Ser Gln Ala Asn Val His Cys Ser Ser Val Pro Thr
        115                 120                 125             
Gly Asp Gln Ser Leu Ser Tyr Val His Gly Ile Pro Arg Arg Lys Leu
    130                 135                 140                 
Arg Asp Trp Ser Leu Glu Gln Met Val Arg Gly Ser Ser Asp Gln Pro
145                 150                 155                 160 
Glu Asp Ile Gly Gln Ser Pro Ser Gly Thr Thr Asn Glu Asp Ala Phe
                165                 170                 175     
Leu Leu Ala Leu Val Arg Arg Glu Leu Lys Ser Arg Pro Leu Ser Ser
            180                 185                 190         
Asn Leu Leu Glu Lys Leu Gln Lys Glu Leu Lys Ile Leu Asp Pro Ile
        195                 200                 205             
Ser Ser Gly Phe Leu Leu Gln Ser Gln Leu Ser Arg Leu Phe Leu Lys
    210                 215                 220                 
His Glu Val Pro Leu Gln Leu Pro Thr Val Lys Ile Leu Cys Gln Arg
225                 230                 235                 240 
Phe Ser Lys Arg Gly Ser Pro Glu Met Val Asn Tyr Glu Lys Leu Leu
                245                 250                 255     
Trp Phe Leu Asn Ser Ala Ala Ser Asp Tyr Pro Gln Gln Asn Lys Ala
            260                 265                 270         
Ala Ala Asp Leu Arg Lys Thr Glu Ser His Gly Thr His Ser Gln Ser
        275                 280                 285             
Thr Pro Pro Gln His Ser Ser Ser Gln Pro Glu Val Asn Arg Ser Leu
    290                 295                 300                 
Leu Glu Ile Leu Lys Met Ala Leu Arg Thr Thr Asn Gly Arg Leu Asn
305                 310                 315                 320 
Ile Asp Asn Leu Asn Leu Ser Phe Arg Lys Glu Asp Arg Ser Phe Ser
                325                 330                 335     
Gly Cys Leu Pro Leu Pro Lys Val Arg Ala Ile Cys Gly Lys His Gly
            340                 345                 350         
Leu Tyr Leu Thr Leu Ser Leu Leu Glu Thr Leu Leu Asn His Gln Asp
        355                 360                 365             
Leu Gly Tyr Gln Asn Glu Ile Lys Trp Gln Asn Phe Val Glu Met Leu
    370                 375                 380                 
Thr Arg Ala Ser Ser Asp Leu Leu Ser Asp Leu Pro Thr Gly Lys Asn
385                 390                 395                 400 
Glu Lys Lys Ala Pro Ala Pro Pro Met Glu Pro Glu Val Pro Glu Met
                405                 410                 415     
Ser Gln Ser Lys Thr Glu His Met Lys Thr Pro Glu Glu Glu Leu Gln
            420                 425                 430         
Pro Glu Ser Ser Pro Ala Glu Thr Ser Ala Cys Lys Asp Pro Leu Lys
        435                 440                 445             
Pro Leu Lys Ile Arg Pro Val Ser Gln Pro Phe Val Asn Pro Ala Val
    450                 455                 460                 
Lys Asn Lys Ala Glu Glu Cys Glu Thr Trp Ile Asp Arg Phe Arg Lys
465                 470                 475                 480 
Leu Glu Asn Ala Leu Tyr Leu Cys Asp Leu Ser Asn Thr Gly Val Leu
                485                 490                 495     
Glu Lys Glu Arg Ala Arg Arg Leu Ile His Asn Tyr Asn Leu Ile Tyr
            500                 505                 510         
Asn Leu Ser Leu Ser Pro Gln Lys Ile Asp Gln Ala Leu Arg Arg Phe
        515                 520                 525             
Arg Ser Gly Glu Asn Met Leu Leu Glu Pro Ala Leu Arg Tyr Leu Lys
    530                 535                 540                 
Glu Leu
545     


<210> 5925
<211> 715
<212> PRT
<213> Homo sapiens

<400> 5925
Met Ser Lys Ala His Lys Pro Trp Pro Tyr Arg Arg Arg Ser Gln Phe
 1               5                  10                  15      
Ser Ser Arg Lys Tyr Leu Lys Lys Glu Met Asn Ser Phe Gln Gln Gln
            20                  25                  30          
Pro Pro Pro Phe Gly Thr Val Pro Pro Gln Met Met Phe Pro Pro Asn
        35                  40                  45              
Trp Gln Gly Ala Glu Lys Asp Ala Ala Phe Leu Ala Lys Asp Phe Asn
    50                  55                  60                  
Phe Leu Thr Leu Asn Asn Gln Pro Pro Pro Gly Asn Arg Ser Gln Pro
65                  70                  75                  80  
Arg Ala Met Gly Pro Glu Asn Asn Leu Tyr Ser Gln Tyr Glu Gln Lys
                85                  90                  95      
Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val
            100                 105                 110         
Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser
        115                 120                 125             
Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro
    130                 135                 140                 
Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys
145                 150                 155                 160 
Lys Gln Pro Cys Glu Ala Trp Ala Gly Arg Ile Ser Tyr Arg Asn Thr
                165                 170                 175     
Glu Leu Glu Leu Gln Asp Pro Gly Gln Val Glu Lys Glu Ile His Lys
            180                 185                 190         
Ala Gln Asn Val Met Ala Gly Asn Gly Arg Gly Ile Ser His Glu Leu
        195                 200                 205             
Ile Ser Leu Glu Ile Thr Ser Pro Glu Val Pro Asp Leu Thr Ile Ile
    210                 215                 220                 
Asp Leu Pro Gly Ile Thr Arg Val Ala Val Asp Asn Gln Pro Arg Asp
225                 230                 235                 240 
Ile Gly Leu Gln Ile Lys Ala Leu Ile Lys Lys Tyr Ile Gln Arg Gln
                245                 250                 255     
Gln Thr Ile Asn Leu Val Val Val Pro Cys Asn Val Asp Ile Ala Thr
            260                 265                 270         
Thr Glu Ala Leu Ser Met Ala His Glu Val Asp Pro Glu Gly Asp Arg
        275                 280                 285             
Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Met Asp Arg Gly Thr Glu
    290                 295                 300                 
Lys Ser Val Met Asn Val Val Arg Asn Leu Thr Tyr Pro Leu Lys Lys
305                 310                 315                 320 
Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Thr Asn Arg
                325                 330                 335     
Leu Ser Leu Ala Glu Ala Thr Lys Lys Glu Ile Thr Phe Phe Gln Thr
            340                 345                 350         
His Pro Tyr Phe Arg Val Leu Leu Glu Glu Gly Ser Ala Thr Val Pro
        355                 360                 365             
Arg Leu Ala Glu Arg Leu Thr Thr Glu Leu Ile Met His Ile Gln Lys
    370                 375                 380                 
Ser Leu Pro Leu Leu Glu Gly Gln Ile Arg Glu Ser His Gln Lys Ala
385                 390                 395                 400 
Thr Glu Glu Leu Arg Arg Cys Gly Ala Asp Ile Pro Ser Gln Glu Ala
                405                 410                 415     
Asp Lys Met Phe Phe Leu Ile Glu Lys Ile Lys Met Phe Asn Gln Asp
            420                 425                 430         
Ile Glu Lys Leu Val Glu Gly Glu Glu Val Val Arg Glu Asn Glu Thr
        435                 440                 445             
Arg Leu Tyr Asn Lys Ile Arg Glu Asp Phe Lys Asn Trp Val Gly Ile
    450                 455                 460                 
Leu Ala Thr Asn Thr Gln Lys Val Lys Asn Ile Ile His Glu Glu Val
465                 470                 475                 480 
Glu Lys Tyr Glu Lys Gln Tyr Arg Gly Lys Glu Leu Leu Gly Phe Val
                485                 490                 495     
Asn Tyr Lys Thr Phe Glu Ile Ile Val His Gln Tyr Ile Gln Gln Leu
            500                 505                 510         
Val Glu Pro Ala Leu Ser Met Leu Gln Lys Ala Met Glu Ile Ile Gln
        515                 520                 525             
Gln Ala Phe Ile Asn Val Ala Lys Lys His Phe Gly Glu Phe Phe Asn
    530                 535                 540                 
Leu Asn Gln Thr Val Gln Ser Thr Ile Glu Asp Ile Lys Val Lys His
545                 550                 555                 560 
Thr Ala Lys Ala Glu Asn Met Ile Gln Leu Gln Phe Arg Met Glu Gln
                565                 570                 575     
Met Val Phe Cys Gln Asp Gln Ile Tyr Ser Val Val Leu Lys Lys Val
            580                 585                 590         
Arg Glu Glu Ile Phe Asn Pro Leu Gly Thr Pro Ser Gln Asn Met Lys
        595                 600                 605             
Leu Asn Ser His Phe Pro Ser Asn Glu Ser Ser Val Ser Ser Phe Thr
    610                 615                 620                 
Glu Ile Gly Ile His Leu Asn Ala Tyr Phe Leu Glu Thr Ser Lys Arg
625                 630                 635                 640 
Leu Ala Asn Gln Ile Pro Phe Ile Ile Gln Tyr Phe Met Leu Arg Glu
                645                 650                 655     
Asn Gly Asp Ser Leu Gln Lys Ala Met Met Gln Ile Leu Gln Glu Lys
            660                 665                 670         
Asn Arg Tyr Ser Trp Leu Leu Gln Glu Gln Ser Glu Thr Ala Thr Lys
        675                 680                 685             
Arg Arg Ile Leu Lys Glu Arg Ile Tyr Arg Leu Thr Gln Ala Arg His
    690                 695                 700                 
Ala Leu Cys Gln Phe Ser Ser Lys Glu Ile His
705                 710                 715 


<210> 5926
<211> 970
<212> PRT
<213> Homo sapiens

<400> 5926
Met Ala Thr Cys Ile Gly Glu Lys Ile Glu Asp Phe Lys Val Gly Asn
 1               5                  10                  15      
Leu Leu Gly Lys Gly Ser Phe Ala Gly Val Tyr Arg Ala Glu Ser Ile
            20                  25                  30          
His Ser Gly Leu Glu Val Ala Ile Lys Met Ile Asp Lys Lys Ala Met
        35                  40                  45              
Tyr Lys Ala Gly Met Val Gln Arg Val Gln Asn Glu Val Lys Ile His
    50                  55                  60                  
Cys Gln Leu Lys His Pro Ser Ile Leu Glu Leu Tyr Asn Tyr Phe Glu
65                  70                  75                  80  
Asp Ser Asn Tyr Val Tyr Leu Val Leu Glu Met Cys His Asn Gly Glu
                85                  90                  95      
Met Asn Arg Tyr Leu Lys Asn Arg Val Lys Pro Phe Ser Glu Asn Glu
            100                 105                 110         
Ala Arg His Phe Met His Gln Ile Ile Thr Gly Met Leu Tyr Leu His
        115                 120                 125             
Ser His Gly Ile Leu His Arg Asp Leu Thr Leu Ser Asn Leu Leu Leu
    130                 135                 140                 
Thr Arg Asn Met Asn Ile Lys Ile Ala Asp Phe Gly Leu Ala Thr Gln
145                 150                 155                 160 
Leu Lys Met Pro His Glu Lys His Tyr Thr Leu Cys Gly Thr Pro Asn
                165                 170                 175     
Tyr Ile Ser Pro Glu Ile Ala Thr Arg Ser Ala His Gly Leu Glu Ser
            180                 185                 190         
Asp Val Trp Ser Leu Gly Cys Met Phe Tyr Thr Leu Leu Ile Gly Arg
        195                 200                 205             
Pro Pro Phe Asp Thr Asp Thr Val Lys Asn Thr Leu Asn Lys Val Val
    210                 215                 220                 
Leu Ala Asp Tyr Glu Met Pro Thr Phe Leu Ser Ile Glu Ala Lys Asp
225                 230                 235                 240 
Leu Ile His Gln Leu Leu Arg Arg Asn Pro Ala Asp Arg Leu Ser Leu
                245                 250                 255     
Ser Ser Val Leu Asp His Pro Phe Met Ser Arg Asn Ser Ser Thr Lys
            260                 265                 270         
Ser Lys Asp Leu Gly Thr Val Glu Asp Ser Ile Asp Ser Gly His Ala
        275                 280                 285             
Thr Ile Ser Thr Ala Ile Thr Ala Ser Ser Ser Thr Ser Ile Ser Gly
    290                 295                 300                 
Ser Leu Phe Asp Lys Arg Arg Leu Leu Ile Gly Gln Pro Leu Pro Asn
305                 310                 315                 320 
Lys Met Thr Val Phe Pro Lys Asn Lys Ser Ser Thr Asp Phe Ser Ser
                325                 330                 335     
Ser Gly Asp Gly Asn Ser Phe Tyr Thr Gln Trp Gly Asn Gln Glu Thr
            340                 345                 350         
Ser Asn Ser Gly Arg Gly Arg Val Ile Gln Asp Ala Glu Glu Arg Pro
        355                 360                 365             
His Ser Arg Tyr Leu Arg Arg Ala Tyr Ser Ser Asp Arg Ser Gly Thr
    370                 375                 380                 
Ser Asn Arg Gln Ser Gln Ala Lys Thr Tyr Thr Met Glu Arg Cys His
385                 390                 395                 400 
Ser Ala Glu Met Leu Ser Val Ser Lys Arg Ser Gly Gly Gly Glu Asn
                405                 410                 415     
Glu Glu Arg Tyr Ser Pro Thr Asp Asn Asn Ala Asn Ile Phe Asn Phe
            420                 425                 430         
Phe Lys Glu Lys Thr Ser Ser Ser Ser Gly Ser Phe Glu Arg Pro Asp
        435                 440                 445             
Asn Asn Gln Ala Leu Ser Asn His Leu Cys Pro Gly Lys Thr Pro Phe
    450                 455                 460                 
Pro Phe Ala Asp Pro Thr Pro Gln Thr Glu Thr Val Gln Gln Trp Phe
465                 470                 475                 480 
Gly Asn Leu Gln Ile Asn Ala His Leu Arg Lys Thr Thr Glu Tyr Asp
                485                 490                 495     
Ser Ile Ser Pro Asn Arg Asp Phe Gln Gly His Pro Asp Leu Gln Lys
            500                 505                 510         
Asp Thr Ser Lys Asn Ala Trp Thr Asp Thr Lys Val Lys Lys Asn Ser
        515                 520                 525             
Asp Ala Ser Asp Asn Ala His Ser Val Lys Gln Gln Asn Thr Met Lys
    530                 535                 540                 
Tyr Met Thr Ala Leu His Ser Lys Pro Glu Ile Ile Gln Gln Glu Cys
545                 550                 555                 560 
Val Phe Gly Ser Asp Pro Leu Ser Glu Gln Ser Lys Thr Arg Gly Met
                565                 570                 575     
Glu Pro Pro Trp Gly Tyr Gln Asn Arg Thr Leu Arg Ser Ile Thr Ser
            580                 585                 590         
Pro Leu Val Ala His Arg Leu Lys Pro Ile Arg Gln Lys Thr Lys Lys
        595                 600                 605             
Ala Val Val Ser Ile Leu Asp Ser Glu Glu Val Cys Val Glu Leu Val
    610                 615                 620                 
Lys Glu Tyr Ala Ser Gln Glu Tyr Val Lys Glu Val Leu Gln Ile Ser
625                 630                 635                 640 
Ser Asp Gly Asn Thr Ile Thr Ile Tyr Tyr Pro Asn Gly Gly Arg Gly
                645                 650                 655     
Phe Pro Leu Ala Asp Arg Pro Pro Ser Pro Thr Asp Asn Ile Ser Arg
            660                 665                 670         
Tyr Ser Phe Asp Asn Leu Pro Glu Lys Tyr Trp Arg Lys Tyr Gln Tyr
        675                 680                 685             
Ala Ser Arg Phe Val Gln Leu Leu Arg Ser Lys Ser Pro Lys Ile Thr
    690                 695                 700                 
Tyr Phe Thr Arg Tyr Ala Lys Cys Ile Leu Met Glu Asn Ser Pro Gly
705                 710                 715                 720 
Ala Asp Phe Glu Val Trp Phe Tyr Asp Gly Val Lys Ile His Lys Thr
                725                 730                 735     
Glu Asp Phe Ile Gln Val Ile Glu Lys Thr Gly Lys Ser Tyr Thr Leu
            740                 745                 750         
Lys Ser Glu Ser Glu Val Asn Ser Leu Lys Glu Glu Ile Lys Met Tyr
        755                 760                 765             
Met Asp His Ala Asn Glu Gly His Arg Ile Cys Leu Ala Leu Glu Ser
    770                 775                 780                 
Ile Ile Ser Glu Glu Glu Arg Lys Thr Arg Ser Ala Pro Phe Phe Pro
785                 790                 795                 800 
Ile Ile Ile Gly Arg Lys Pro Gly Ser Thr Ser Ser Pro Lys Ala Leu
                805                 810                 815     
Ser Pro Pro Pro Ser Val Asp Ser Asn Tyr Pro Thr Arg Asp Arg Ala
            820                 825                 830         
Ser Phe Asn Arg Met Val Met His Ser Asp Ala Ser Pro Thr Gln Ala
        835                 840                 845             
Pro Ile Leu Asn Pro Ser Met Val Thr Asn Glu Gly Leu Gly Leu Thr
    850                 855                 860                 
Thr Thr Ala Ser Gly Thr Asp Ile Ser Ser Asn Ser Leu Lys Asp Cys
865                 870                 875                 880 
Leu Pro Lys Ser Ala Gln Leu Leu Lys Ser Val Phe Val Lys Asn Val
                885                 890                 895     
Gly Trp Ala Thr Gln Leu Thr Ser Gly Ala Val Trp Val Gln Phe Asn
            900                 905                 910         
Asp Gly Ser Gln Leu Val Val Gln Ala Gly Val Ser Ser Ile Ser Tyr
        915                 920                 925             
Thr Ser Pro Asn Gly Gln Thr Thr Arg Tyr Gly Glu Asn Glu Lys Leu
    930                 935                 940                 
Pro Asp Tyr Ile Lys Gln Lys Leu Gln Cys Leu Ser Ser Ile Leu Leu
945                 950                 955                 960 
Met Phe Ser Asn Pro Thr Pro Asn Phe His
                965                 970 


<210> 5927
<211> 970
<212> PRT
<213> Homo sapiens

<400> 5927
Met Ala Thr Cys Ile Gly Glu Lys Ile Glu Asp Phe Lys Val Gly Asn
 1               5                  10                  15      
Leu Leu Gly Lys Gly Ser Phe Ala Gly Val Tyr Arg Ala Glu Ser Ile
            20                  25                  30          
His Thr Gly Leu Glu Val Ala Ile Lys Met Ile Asp Lys Lys Ala Met
        35                  40                  45              
Tyr Lys Ala Gly Met Val Gln Arg Val Lys Asn Glu Val Lys Ile His
    50                  55                  60                  
Cys Gln Leu Lys His Pro Ser Ile Leu Glu Leu Tyr Asn Tyr Phe Glu
65                  70                  75                  80  
Asp Ser Asn Tyr Val Tyr Leu Val Leu Glu Met Cys His Asn Gly Glu
                85                  90                  95      
Met Asn Arg Tyr Leu Lys Asn Arg Val Lys Pro Phe Ser Glu Asn Glu
            100                 105                 110         
Ala Arg His Phe Met His Gln Ile Ile Thr Gly Met Leu Tyr Leu His
        115                 120                 125             
Ser His Gly Ile Leu His Arg Asp Leu Thr Leu Ser Asn Leu Leu Leu
    130                 135                 140                 
Thr Arg Asn Met Asn Ile Lys Ile Ala Asp Phe Gly Leu Ala Thr Gln
145                 150                 155                 160 
Leu Lys Met Pro His Glu Lys His Tyr Thr Leu Cys Gly Thr Pro Asn
                165                 170                 175     
Tyr Ile Ser Pro Glu Ile Ala Thr Arg Ser Ala His Gly Leu Glu Ser
            180                 185                 190         
Asp Val Trp Ser Leu Gly Cys Met Phe Tyr Thr Leu Leu Ile Gly Arg
        195                 200                 205             
Pro Pro Phe Asp Thr Asp Thr Val Lys Asn Thr Leu Asn Lys Val Val
    210                 215                 220                 
Leu Ala Asp Tyr Glu Met Pro Thr Phe Leu Ser Ile Glu Ala Lys Asp
225                 230                 235                 240 
Leu Ile His Gln Leu Leu Arg Arg Asn Pro Ala Asp Arg Leu Ser Leu
                245                 250                 255     
Ser Ser Val Leu Asp His Pro Phe Met Ser Arg Asn Ser Ser Thr Lys
            260                 265                 270         
Ser Lys Asp Leu Gly Thr Val Glu Asp Ser Ile Asp Ser Gly His Ala
        275                 280                 285             
Thr Ile Ser Thr Ala Ile Thr Ala Ser Ser Ser Thr Ser Ile Ser Gly
    290                 295                 300                 
Ser Leu Phe Asp Lys Arg Arg Leu Leu Ile Gly Gln Pro Leu Pro Asn
305                 310                 315                 320 
Lys Met Thr Val Phe Pro Lys Asn Lys Ser Ser Thr Asp Phe Ser Ser
                325                 330                 335     
Ser Gly Asp Gly Asn Ser Phe Tyr Thr Gln Trp Gly Asn Gln Glu Thr
            340                 345                 350         
Ser Asn Ser Gly Arg Gly Arg Val Ile Gln Asp Ala Glu Glu Arg Pro
        355                 360                 365             
His Ser Arg Tyr Leu Arg Arg Ala Tyr Ser Ser Asp Arg Ser Gly Thr
    370                 375                 380                 
Ser Asn Ser Gln Ser Gln Ala Lys Thr Tyr Thr Met Glu Arg Cys His
385                 390                 395                 400 
Ser Ala Glu Met Leu Ser Val Ser Lys Arg Ser Gly Gly Gly Glu Asn
                405                 410                 415     
Glu Glu Arg Tyr Ser Pro Thr Asp Asn Asn Ala Asn Ile Phe Asn Phe
            420                 425                 430         
Phe Lys Glu Lys Thr Ser Ser Ser Ser Gly Ser Phe Glu Arg Pro Asp
        435                 440                 445             
Asn Asn Gln Ala Leu Ser Asn His Leu Cys Pro Gly Lys Thr Pro Phe
    450                 455                 460                 
Pro Phe Ala Asp Pro Thr Pro Gln Thr Glu Thr Val Gln Gln Trp Phe
465                 470                 475                 480 
Gly Asn Leu Gln Ile Asn Ala His Leu Arg Lys Thr Thr Glu Tyr Asp
                485                 490                 495     
Ser Ile Ser Pro Asn Arg Asp Phe Gln Gly His Pro Asp Leu Gln Lys
            500                 505                 510         
Asp Thr Ser Lys Asn Ala Trp Thr Asp Thr Lys Val Lys Lys Asn Ser
        515                 520                 525             
Asp Ala Ser Asp Asn Ala His Ser Val Lys Gln Gln Asn Thr Met Lys
    530                 535                 540                 
Tyr Met Thr Ala Leu His Ser Lys Pro Glu Ile Ile Gln Gln Glu Cys
545                 550                 555                 560 
Val Phe Gly Ser Asp Pro Leu Ser Glu Gln Ser Lys Thr Arg Gly Met
                565                 570                 575     
Glu Pro Pro Trp Gly Tyr Gln Asn Arg Thr Leu Arg Ser Ile Thr Ser
            580                 585                 590         
Pro Leu Val Ala His Arg Leu Lys Pro Ile Arg Gln Lys Thr Lys Lys
        595                 600                 605             
Ala Val Val Ser Ile Leu Asp Ser Glu Glu Val Cys Val Glu Leu Val
    610                 615                 620                 
Lys Glu Tyr Ala Ser Gln Glu Tyr Val Lys Glu Val Leu Gln Ile Ser
625                 630                 635                 640 
Ser Asp Gly Asn Thr Ile Thr Ile Tyr Tyr Pro Asn Gly Gly Arg Gly
                645                 650                 655     
Phe Pro Leu Ala Asp Arg Pro Pro Ser Pro Thr Asp Asn Ile Ser Arg
            660                 665                 670         
Tyr Ser Phe Asp Asn Leu Pro Glu Lys Tyr Trp Arg Lys Tyr Gln Tyr
        675                 680                 685             
Ala Ser Arg Phe Val Gln Leu Val Arg Ser Lys Ser Pro Lys Ile Thr
    690                 695                 700                 
Tyr Phe Thr Arg Tyr Ala Lys Cys Ile Leu Met Glu Asn Ser Pro Gly
705                 710                 715                 720 
Ala Asp Phe Glu Val Trp Phe Tyr Asp Gly Val Lys Ile His Lys Thr
                725                 730                 735     
Glu Asp Phe Ile Gln Val Ile Glu Lys Thr Gly Lys Ser Tyr Thr Leu
            740                 745                 750         
Lys Ser Glu Ser Glu Val Asn Ser Leu Lys Glu Glu Ile Lys Met Phe
        755                 760                 765             
Met Asp His Ala Asn Glu Gly His Arg Ile Cys Leu Ala Leu Glu Ser
    770                 775                 780                 
Ile Ile Ser Glu Glu Glu Arg Lys Thr Arg Ser Ala Pro Phe Phe Pro
785                 790                 795                 800 
Ile Ile Ile Gly Arg Lys Pro Gly Ser Thr Ser Ser Pro Lys Ala Leu
                805                 810                 815     
Ser Pro Pro Pro Ser Val Asp Ser Asn Tyr Pro Thr Arg Asp Arg Ala
            820                 825                 830         
Ser Phe Asn Arg Met Val Met His Ser Ala Ala Ser Pro Thr Gln Ala
        835                 840                 845             
Pro Ile Leu Asn Pro Ser Met Val Thr Asn Glu Gly Leu Gly Leu Thr
    850                 855                 860                 
Thr Thr Ala Ser Gly Thr Asp Ile Ser Ser Asn Ser Leu Lys Asp Cys
865                 870                 875                 880 
Leu Pro Lys Ser Ala Gln Leu Leu Lys Ser Val Phe Val Lys Asn Val
                885                 890                 895     
Gly Trp Ala Thr Gln Leu Thr Ser Gly Ala Val Trp Val Gln Phe Asn
            900                 905                 910         
Asp Gly Ser Gln Leu Val Val Gln Ala Gly Val Ser Ser Ile Ser Tyr
        915                 920                 925             
Thr Ser Pro Asn Gly Gln Thr Thr Arg Tyr Gly Glu Asn Glu Lys Leu
    930                 935                 940                 
Pro Asp Tyr Ile Lys Gln Lys Leu Gln Cys Leu Ser Ser Ile Leu Leu
945                 950                 955                 960 
Met Phe Ser Asn Pro Thr Pro Asn Phe His
                965                 970 


<210> 5928
<211> 1047
<212> PRT
<213> Homo sapiens

<400> 5928
Met Asp Ala Glu Ala Glu Asp Lys Thr Leu Arg Thr Arg Ser Lys Gly
 1               5                  10                  15      
Thr Glu Val Pro Met Asp Ser Leu Ile Gln Glu Leu Ser Val Ala Tyr
            20                  25                  30          
Asp Cys Ser Met Ala Lys Lys Arg Thr Ala Glu Asp Gln Ala Leu Gly
        35                  40                  45              
Val Pro Val Asn Lys Arg Lys Ser Leu Leu Met Lys Pro Arg His Tyr
    50                  55                  60                  
Ser Pro Lys Ala Asp Cys Gln Glu Asp Arg Ser Asp Arg Thr Glu Asp
65                  70                  75                  80  
Asp Gly Pro Leu Glu Thr His Gly His Ser Thr Ala Glu Glu Ile Met
                85                  90                  95      
Ile Lys Pro Met Asp Glu Ser Leu Leu Ser Thr Ala Gln Glu Asn Ser
            100                 105                 110         
Ser Arg Lys Glu Asp Arg Tyr Ser Cys Tyr Gln Glu Leu Met Val Lys
        115                 120                 125             
Ser Leu Met His Leu Gly Lys Phe Glu Lys Asn Val Ser Val Gln Thr
    130                 135                 140                 
Val Ser Glu Asn Leu Asn Asp Ser Gly Ile Gln Ser Leu Lys Ala Glu
145                 150                 155                 160 
Ser Asp Glu Ala Asp Glu Cys Phe Leu Ile His Ser Asp Asp Gly Arg
                165                 170                 175     
Asp Lys Ile Asp Asp Ser Gln Pro Pro Phe Cys Ser Ser Asp Asp Asn
            180                 185                 190         
Glu Ser Asn Ser Glu Ser Ala Glu Asn Gly Trp Asp Ser Gly Ser Asn
        195                 200                 205             
Phe Ser Glu Glu Thr Lys Pro Pro Arg Val Pro Lys Tyr Val Leu Thr
    210                 215                 220                 
Asp His Lys Lys Asp Leu Leu Glu Val Pro Glu Ile Lys Thr Glu Gly
225                 230                 235                 240 
Asp Lys Phe Ile Pro Cys Glu Asn Arg Cys Asp Ser Glu Thr Glu Arg
                245                 250                 255     
Lys Asp Pro Gln Asn Ala Leu Ala Glu Pro Leu Asp Gly Asn Ala Gln
            260                 265                 270         
Pro Ser Phe Pro Asp Val Glu Glu Glu Asp Ser Glu Ser Leu Ala Val
        275                 280                 285             
Met Thr Glu Glu Gly Ser Asp Leu Glu Lys Ala Lys Gly Asn Leu Ser
    290                 295                 300                 
Leu Leu Glu Gln Ala Ile Ala Leu Gln Ala Glu Arg Gly Cys Val Phe
305                 310                 315                 320 
His Asn Thr Tyr Lys Glu Leu Asp Arg Phe Leu Leu Glu His Leu Ala
                325                 330                 335     
Gly Glu Arg Arg Gln Thr Lys Val Ile Asp Met Gly Gly Arg Gln Ile
            340                 345                 350         
Phe Asn Asn Lys His Ser Pro Arg Pro Glu Lys Arg Glu Thr Lys Cys
        355                 360                 365             
Pro Ile Pro Gly Cys Asp Gly Thr Gly His Val Thr Gly Leu Tyr Pro
    370                 375                 380                 
His His Arg Ser Leu Ser Gly Cys Pro His Lys Val Arg Val Pro Leu
385                 390                 395                 400 
Glu Ile Leu Ala Met His Glu Asn Val Leu Lys Cys Pro Thr Pro Gly
                405                 410                 415     
Cys Thr Gly Arg Gly His Val Asn Ser Asn Arg Asn Thr His Arg Ser
            420                 425                 430         
Leu Ser Gly Cys Pro Ile Ala Ala Ala Glu Lys Leu Ala Met Ser Gln
        435                 440                 445             
Asp Lys Asn Gln Leu Asp Ser Pro Gln Thr Gly Gln Cys Pro Asp Gln
    450                 455                 460                 
Ala His Arg Thr Ser Leu Val Lys Gln Ile Glu Phe Asn Phe Pro Ser
465                 470                 475                 480 
Gln Ala Ile Thr Ser Pro Arg Ala Thr Val Ser Lys Glu Gln Glu Lys
                485                 490                 495     
Phe Gly Lys Val Pro Phe Asp Tyr Ala Ser Phe Asp Ala Gln Val Phe
            500                 505                 510         
Gly Lys Arg Pro Leu Ile Gln Thr Val Gln Gly Arg Lys Thr Pro Pro
        515                 520                 525             
Phe Pro Glu Ser Lys His Phe Pro Asn Pro Val Lys Phe Pro Asn Arg
    530                 535                 540                 
Leu Pro Ser Ala Gly Ala His Thr Gln Ser Pro Gly Arg Ala Ser Ser
545                 550                 555                 560 
Tyr Ser Tyr Gly Gln Cys Ser Glu Asp Thr His Ile Ala Ala Ala Ala
                565                 570                 575     
Ala Ile Leu Asn Leu Ser Thr Arg Cys Arg Glu Ala Thr Asp Ile Leu
            580                 585                 590         
Ser Asn Lys Pro Gln Ser Leu His Ala Lys Gly Ala Glu Ile Glu Val
        595                 600                 605             
Asp Glu Asn Gly Thr Leu Asp Leu Ser Met Lys Lys Asn Arg Ile Leu
    610                 615                 620                 
Asp Lys Ser Ala Pro Leu Thr Ser Ser Asn Thr Ser Ile Pro Thr Pro
625                 630                 635                 640 
Ser Ser Ser Pro Phe Lys Thr Ser Ser Ile Leu Val Asn Ala Ala Phe
                645                 650                 655     
Tyr Gln Ala Leu Cys Asp Gln Glu Gly Trp Asp Thr Pro Ile Asn Tyr
            660                 665                 670         
Ser Lys Thr His Gly Lys Thr Glu Glu Glu Lys Glu Lys Asp Pro Val
        675                 680                 685             
Ser Ser Leu Glu Asn Leu Glu Glu Lys Lys Phe Pro Gly Glu Ala Ser
    690                 695                 700                 
Ile Pro Ser Pro Lys Pro Lys Leu His Ala Arg Asp Leu Lys Lys Glu
705                 710                 715                 720 
Leu Ile Thr Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His Val Thr
                725                 730                 735     
Gly Asn Tyr Ala Ser His Arg Ser Val Ser Gly Cys Pro Leu Ala Asp
            740                 745                 750         
Lys Thr Leu Lys Ser Leu Met Ala Ala Asn Ser Gln Glu Leu Lys Cys
        755                 760                 765             
Pro Thr Pro Gly Cys Asp Gly Ser Gly His Val Thr Gly Asn Tyr Ala
    770                 775                 780                 
Ser His Arg Ser Leu Ser Gly Cys Pro Arg Ala Arg Lys Gly Gly Val
785                 790                 795                 800 
Lys Met Thr Pro Thr Lys Glu Glu Lys Glu Asp Pro Glu Leu Lys Cys
                805                 810                 815     
Pro Val Ile Gly Cys Asp Gly Gln Gly His Ile Ser Gly Lys Tyr Thr
            820                 825                 830         
Ser His Arg Thr Ala Ser Gly Cys Pro Leu Ala Ala Lys Arg Gln Lys
        835                 840                 845             
Glu Asn Pro Leu Asn Gly Ala Ser Leu Ser Trp Lys Leu Asn Lys Gln
    850                 855                 860                 
Glu Leu Pro His Cys Pro Leu Pro Gly Cys Asn Gly Leu Gly His Val
865                 870                 875                 880 
Asn Asn Val Phe Val Thr His Arg Ser Leu Ser Gly Cys Pro Leu Asn
                885                 890                 895     
Ala Gln Val Ile Lys Lys Gly Lys Val Ser Glu Glu Leu Met Thr Ile
            900                 905                 910         
Lys Leu Lys Ala Thr Gly Gly Ile Glu Ser Asp Glu Glu Ile Arg His
        915                 920                 925             
Leu Asp Glu Glu Ile Lys Glu Leu Asn Glu Ser Asn Leu Lys Ile Glu
    930                 935                 940                 
Ala Asp Met Met Lys Leu Gln Thr Gln Ile Thr Ser Met Glu Ser Asn
945                 950                 955                 960 
Leu Lys Thr Ile Glu Glu Glu Asn Lys Leu Ile Glu Gln Asn Asn Glu
                965                 970                 975     
Ser Leu Leu Lys Glu Leu Ala Gly Leu Ser Gln Ala Leu Ile Ser Ser
            980                 985                 990         
Leu Ala Asp Ile Gln Leu Pro Gln Met Gly Pro Ile Ser Glu Gln Asn
        995                 1000                1005            
Phe Glu Ala Tyr Val Asn Thr Leu Thr Asp Met Tyr Ser Asn Leu Glu
    1010                1015                1020                
Arg Asp Tyr Ser Pro Glu Cys Lys Ala Leu Leu Glu Ser Ile Lys Gln
1025                1030                1035                1040
Ala Val Lys Gly Ile His Val
                1045        


<210> 5929
<211> 3427
<212> PRT
<213> Homo sapiens

<400> 5929
Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg
            20                  25                  30          
Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly
        35                  40                  45              
Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn
    50                  55                  60                  
Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr
65                  70                  75                  80  
Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr
                85                  90                  95      
Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe
            100                 105                 110         
Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val
        115                 120                 125             
Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile
    130                 135                 140                 
Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr
145                 150                 155                 160 
Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln
                165                 170                 175     
Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu
            180                 185                 190         
Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser
        195                 200                 205             
Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn
    210                 215                 220                 
Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val
225                 230                 235                 240 
Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu
                245                 250                 255     
Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser
            260                 265                 270         
Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys
        275                 280                 285             
Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser
    290                 295                 300                 
Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys
305                 310                 315                 320 
Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly
                325                 330                 335     
Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn
            340                 345                 350         
Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp
        355                 360                 365             
Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys
    370                 375                 380                 
Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu
385                 390                 395                 400 
Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile
                405                 410                 415     
Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp
            420                 425                 430         
Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly
        435                 440                 445             
Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro
    450                 455                 460                 
Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met
465                 470                 475                 480 
Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu
                485                 490                 495     
Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu
            500                 505                 510         
Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn
        515                 520                 525             
Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn
    530                 535                 540                 
His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val
545                 550                 555                 560 
Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile
                565                 570                 575     
Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu
            580                 585                 590         
Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys
        595                 600                 605             
Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr
    610                 615                 620                 
Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro
625                 630                 635                 640 
Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly
                645                 650                 655     
Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro
            660                 665                 670         
Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly
        675                 680                 685             
Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser
    690                 695                 700                 
Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu
705                 710                 715                 720 
Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe
                725                 730                 735     
Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Glu
            740                 745                 750         
Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg
        755                 760                 765             
Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr
    770                 775                 780                 
Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser
785                 790                 795                 800 
Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu
                805                 810                 815     
Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala
            820                 825                 830         
Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser
        835                 840                 845             
Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val
    850                 855                 860                 
Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr
865                 870                 875                 880 
Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His
                885                 890                 895     
Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met
            900                 905                 910         
Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile
        915                 920                 925             
Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met
    930                 935                 940                 
Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp
945                 950                 955                 960 
His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu
                965                 970                 975     
Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg
            980                 985                 990         
Arg Val Ile Val Leu Leu Pro Gln Lys Thr Trp Ser Ser Ala Thr Arg
        995                 1000                1005            
Phe Arg Trp Ser Gln Ser Tyr Tyr Thr Ala Gln Asp Glu Trp Ala Leu
    1010                1015                1020                
Asp Ser Ile Tyr Ile Gly Gln Gln Cys Pro Asn Met Cys Ser Gly His
1025                1030                1035                1040
Gly Ser Cys Asp His Gly Ile Cys Arg Cys Asp Gln Gly Tyr Gln Gly
                1045                1050                1055    
Thr Glu Cys His Pro Glu Ala Ala Leu Pro Ser Thr Ile Met Ser Asp
            1060                1065                1070        
Phe Glu Asn Gln Asn Gly Trp Glu Ser Asp Trp Gln Glu Val Ile Gly
        1075                1080                1085            
Gly Glu Ile Val Lys Pro Glu Gln Gly Cys Gly Val Ile Ser Ser Gly
    1090                1095                1100                
Ser Ser Leu Tyr Phe Ser Lys Ala Gly Lys Arg Gln Leu Val Ser Trp
1105                1110                1115                1120
Asp Leu Asp Thr Ser Trp Val Asp Phe Val Gln Phe Tyr Ile Gln Ile
                1125                1130                1135    
Gly Gly Glu Ser Ala Ser Cys Asn Lys Pro Asp Ser Arg Glu Glu Gly
            1140                1145                1150        
Val Leu Leu Gln Tyr Ser Asn Asn Gly Gly Ile Gln Trp His Leu Leu
        1155                1160                1165            
Ala Glu Met Tyr Phe Ser Asp Phe Ser Lys Pro Arg Phe Val Tyr Leu
    1170                1175                1180                
Glu Leu Pro Ala Ala Ala Lys Thr Pro Cys Thr Arg Phe Arg Trp Trp
1185                1190                1195                1200
Gln Pro Val Phe Ser Gly Glu Asp Tyr Asp Gln Trp Ala Val Asp Asp
                1205                1210                1215    
Ile Ile Ile Leu Ser Glu Lys Gln Lys Gln Ile Ile Pro Val Ile Asn
            1220                1225                1230        
Pro Thr Leu Pro Gln Asn Phe Tyr Glu Lys Pro Ala Phe Asp Tyr Pro
        1235                1240                1245            
Met Asn Gln Met Ser Val Trp Leu Met Leu Ala Asn Glu Gly Met Val
    1250                1255                1260                
Lys Asn Glu Thr Phe Cys Ala Ala Thr Pro Ser Ala Met Ile Phe Gly
1265                1270                1275                1280
Lys Ser Asp Gly Asp Arg Phe Ala Val Thr Arg Asp Leu Thr Leu Lys
                1285                1290                1295    
Pro Gly Tyr Val Leu Gln Phe Lys Leu Asn Ile Gly Cys Ala Asn Gln
            1300                1305                1310        
Phe Ser Ser Thr Ala Pro Val Leu Leu Gln Tyr Ser His Asp Ala Gly
        1315                1320                1325            
Met Ser Trp Phe Leu Val Lys Glu Gly Cys Tyr Pro Ala Ser Ala Gly
    1330                1335                1340                
Lys Gly Cys Glu Gly Asn Ser Arg Glu Leu Ser Glu Pro Thr Met Tyr
1345                1350                1355                1360
His Thr Gly Asp Phe Glu Glu Trp Thr Arg Ile Thr Ile Val Ile Pro
                1365                1370                1375    
Arg Ser Leu Ala Ser Ser Lys Thr Arg Phe Arg Trp Ile Gln Glu Ser
            1380                1385                1390        
Ser Ser Gln Lys Asn Val Pro Pro Phe Gly Leu Asp Gly Val Tyr Ile
        1395                1400                1405            
Ser Glu Pro Cys Pro Ser Tyr Cys Ser Gly His Gly Asp Cys Ile Ser
    1410                1415                1420                
Gly Val Cys Phe Cys Asp Leu Gly Tyr Thr Ala Ala Gln Gly Thr Cys
1425                1430                1435                1440
Val Ser Asn Val Pro Asn His Asn Glu Met Phe Asp Arg Phe Glu Gly
                1445                1450                1455    
Lys Leu Ser Pro Leu Trp Tyr Lys Ile Thr Gly Ala Gln Val Gly Thr
            1460                1465                1470        
Gly Cys Gly Thr Leu Asn Asp Gly Lys Ser Leu Tyr Phe Asn Gly Pro
        1475                1480                1485            
Gly Lys Arg Glu Ala Arg Thr Val Pro Leu Asp Thr Arg Asn Ile Arg
    1490                1495                1500                
Leu Val Gln Phe Tyr Ile Gln Ile Gly Ser Lys Thr Ser Gly Ile Thr
1505                1510                1515                1520
Cys Ile Lys Pro Arg Thr Arg Asn Glu Gly Leu Ile Val Gln Tyr Ser
                1525                1530                1535    
Asn Asp Asn Gly Ile Leu Trp His Leu Leu Arg Glu Leu Asp Phe Met
            1540                1545                1550        
Ser Phe Leu Glu Pro Gln Ile Ile Ser Ile Asp Leu Pro Gln Asp Ala
        1555                1560                1565            
Lys Thr Pro Ala Thr Ala Phe Arg Trp Trp Gln Pro Gln His Gly Lys
    1570                1575                1580                
His Ser Ala Gln Trp Ala Leu Asp Asp Val Leu Ile Gly Met Asn Asp
1585                1590                1595                1600
Ser Ser Gln Thr Gly Phe Gln Asp Lys Phe Asp Gly Ser Ile Asp Leu
                1605                1610                1615    
Gln Ala Asn Trp Tyr Arg Ile Gln Gly Gly Gln Val Asp Ile Asp Cys
            1620                1625                1630        
Leu Ser Met Asp Thr Ala Leu Ile Phe Thr Glu Asn Ile Gly Lys Pro
        1635                1640                1645            
Arg Tyr Ala Glu Thr Trp Asp Phe His Val Ser Ala Ser Thr Phe Leu
    1650                1655                1660                
Gln Phe Glu Met Ser Met Gly Cys Ser Lys Pro Phe Ser Asn Ser His
1665                1670                1675                1680
Ser Val Gln Leu Gln Tyr Ser Leu Asn Asn Gly Lys Asp Trp His Leu
                1685                1690                1695    
Val Thr Glu Glu Cys Val Pro Pro Thr Ile Gly Cys Leu His Tyr Thr
            1700                1705                1710        
Glu Ser Ser Ile Tyr Thr Ser Glu Arg Phe Gln Asn Trp Lys Arg Ile
        1715                1720                1725            
Thr Val Tyr Leu Pro Leu Ser Thr Ile Ser Pro Arg Thr Arg Phe Arg
    1730                1735                1740                
Trp Ile Gln Ala Asn Tyr Thr Val Gly Ala Asp Ser Trp Ala Ile Asp
1745                1750                1755                1760
Asn Val Val Leu Ala Ser Gly Cys Pro Trp Met Cys Ser Gly Arg Gly
                1765                1770                1775    
Ile Cys Asp Ala Gly Arg Cys Val Cys Asp Arg Gly Phe Gly Gly Pro
            1780                1785                1790        
Tyr Cys Val Pro Val Val Pro Leu Pro Ser Ile Leu Lys Asp Asp Phe
        1795                1800                1805            
Asn Gly Asn Leu His Pro Asp Leu Trp Pro Glu Val Tyr Gly Ala Glu
    1810                1815                1820                
Arg Gly Asn Leu Asn Gly Glu Thr Ile Lys Ser Gly Thr Ser Leu Ile
1825                1830                1835                1840
Phe Lys Gly Glu Gly Leu Arg Met Leu Ile Ser Arg Asp Leu Asp Cys
                1845                1850                1855    
Thr Asn Thr Met Tyr Val Gln Phe Ser Leu Arg Phe Ile Ala Lys Ser
            1860                1865                1870        
Thr Pro Glu Arg Ser His Ser Ile Leu Leu Gln Phe Ser Ile Ser Gly
        1875                1880                1885            
Gly Ile Thr Trp His Leu Met Asp Glu Phe Tyr Phe Pro Gln Thr Thr
    1890                1895                1900                
Asn Ile Leu Phe Ile Asn Val Pro Leu Pro Tyr Thr Ala Gln Thr Asn
1905                1910                1915                1920
Ala Thr Arg Phe Arg Leu Trp Gln Pro Tyr Asn Asn Gly Lys Lys Glu
                1925                1930                1935    
Glu Ile Trp Ile Val Asp Asp Phe Ile Ile Asp Gly Asn Asn Val Asn
            1940                1945                1950        
Asn Pro Val Met Leu Leu Asp Thr Phe Asp Phe Gly Pro Arg Glu Asp
        1955                1960                1965            
Asn Trp Phe Phe Tyr Pro Gly Gly Asn Ile Gly Leu Tyr Cys Pro Tyr
    1970                1975                1980                
Ser Ser Lys Gly Ala Pro Glu Glu Asp Ser Ala Met Val Phe Val Ser
1985                1990                1995                2000
Asn Glu Val Gly Glu His Ser Ile Thr Thr Arg Asp Leu Asn Val Asn
                2005                2010                2015    
Glu Asn Thr Ile Ile Gln Phe Glu Ile Asn Val Gly Cys Ser Thr Asp
            2020                2025                2030        
Ser Ser Ser Ala Asp Pro Val Arg Leu Glu Phe Ser Arg Asp Phe Gly
        2035                2040                2045            
Ala Thr Trp His Leu Leu Leu Pro Leu Cys Tyr His Ser Ser Ser His
    2050                2055                2060                
Val Ser Ser Leu Cys Ser Thr Glu His His Pro Ser Ser Thr Tyr Tyr
2065                2070                2075                2080
Ala Gly Thr Met Gln Gly Trp Arg Arg Glu Val Val His Phe Gly Lys
                2085                2090                2095    
Leu His Leu Cys Gly Ser Val Arg Phe Arg Trp Tyr Gln Gly Phe Tyr
            2100                2105                2110        
Pro Ala Gly Ser Gln Pro Val Thr Trp Ala Ile Asp Asn Val Tyr Ile
        2115                2120                2125            
Gly Pro Gln Cys Glu Glu Met Cys Asn Gly Gln Gly Ser Cys Ile Asn
    2130                2135                2140                
Gly Thr Lys Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro Thr Cys Lys
2145                2150                2155                2160
Ile Ser Thr Lys Asn Pro Asp Phe Leu Lys Asp Asp Phe Glu Gly Gln
                2165                2170                2175    
Leu Glu Ser Asp Arg Phe Leu Leu Met Ser Gly Gly Lys Pro Ser Arg
            2180                2185                2190        
Lys Cys Gly Ile Leu Ser Ser Gly Asn Asn Leu Phe Phe Asn Glu Asp
        2195                2200                2205            
Gly Leu Arg Met Leu Met Thr Arg Asp Leu Asp Leu Ser His Ala Arg
    2210                2215                2220                
Phe Val Gln Phe Phe Met Arg Leu Gly Cys Gly Lys Gly Val Pro Asp
2225                2230                2235                2240
Pro Arg Ser Gln Pro Val Leu Leu Gln Tyr Ser Leu Asn Gly Gly Leu
                2245                2250                2255    
Ser Trp Ser Leu Leu Gln Glu Phe Leu Phe Ser Asn Ser Ser Asn Val
            2260                2265                2270        
Gly Arg Tyr Ile Ala Leu Glu Ile Pro Leu Lys Ala Arg Ser Gly Ser
        2275                2280                2285            
Thr Arg Leu Arg Trp Trp Gln Pro Ser Glu Asn Gly His Phe Tyr Ser
    2290                2295                2300                
Pro Trp Val Ile Asp Gln Ile Leu Ile Gly Gly Asn Ile Ser Gly Asn
2305                2310                2315                2320
Thr Val Leu Glu Asp Asp Phe Thr Thr Leu Asp Ser Arg Lys Trp Leu
                2325                2330                2335    
Leu His Pro Gly Gly Thr Lys Met Pro Val Cys Gly Ser Thr Gly Asp
            2340                2345                2350        
Ala Leu Val Phe Ile Glu Lys Ala Ser Thr Arg Tyr Val Val Ser Thr
        2355                2360                2365            
Asp Val Ala Val Asn Glu Asp Ser Phe Leu Gln Ile Asp Phe Ala Ala
    2370                2375                2380                
Ser Cys Ser Val Thr Asp Ser Cys Tyr Ala Ile Glu Leu Glu Tyr Ser
2385                2390                2395                2400
Val Asp Leu Gly Leu Ser Trp His Pro Leu Val Arg Asp Cys Leu Pro
                2405                2410                2415    
Thr Asn Val Glu Cys Ser Arg Tyr His Leu Gln Arg Ile Leu Val Ser
            2420                2425                2430        
Asp Thr Phe Asn Lys Trp Thr Arg Ile Thr Leu Pro Leu Pro Pro Tyr
        2435                2440                2445            
Thr Arg Ser Gln Ala Thr Arg Phe Arg Trp His Gln Pro Ala Pro Phe
    2450                2455                2460                
Asp Lys Gln Gln Thr Trp Ala Ile Asp Asn Val Tyr Ile Gly Asp Gly
2465                2470                2475                2480
Cys Ile Asp Met Cys Ser Gly His Gly Arg Cys Ile Gln Gly Asn Cys
                2485                2490                2495    
Val Cys Asp Glu Gln Trp Gly Gly Leu Tyr Cys Asp Asp Pro Glu Thr
            2500                2505                2510        
Ser Leu Pro Thr Gln Leu Lys Asp Asn Phe Asn Arg Ala Pro Ser Ser
        2515                2520                2525            
Gln Asn Trp Leu Thr Val Asn Gly Gly Lys Leu Ser Thr Val Cys Gly
    2530                2535                2540                
Ala Val Ala Ser Gly Met Ala Leu His Phe Ser Gly Gly Cys Ser Arg
2545                2550                2555                2560
Leu Leu Val Thr Val Asp Leu Asn Leu Thr Asn Ala Glu Phe Ile Gln
                2565                2570                2575    
Phe Tyr Phe Met Tyr Gly Cys Leu Ile Thr Pro Asn Asn Arg Asn Gln
            2580                2585                2590        
Gly Val Leu Leu Glu Tyr Ser Val Asn Gly Gly Ile Thr Trp Asn Leu
        2595                2600                2605            
Leu Met Glu Ile Phe Tyr Asp Gln Tyr Ser Lys Pro Gly Phe Val Asn
    2610                2615                2620                
Ile Leu Leu Pro Pro Asp Ala Lys Glu Ile Ala Thr Arg Phe Arg Trp
2625                2630                2635                2640
Trp Gln Pro Arg His Asp Gly Leu Asp Gln Asn Asp Trp Ala Ile Asp
                2645                2650                2655    
Asn Val Leu Ile Ser Gly Ser Ala Asp Gln Arg Thr Val Met Leu Asp
            2660                2665                2670        
Thr Phe Ser Ser Ala Pro Val Pro Gln His Glu Arg Ser Pro Ala Asp
        2675                2680                2685            
Ala Gly Pro Val Gly Arg Ile Ala Phe Asp Met Phe Met Glu Asp Lys
    2690                2695                2700                
Thr Ser Val Asn Glu His Trp Leu Phe His Asp Asp Cys Thr Val Glu
2705                2710                2715                2720
Arg Phe Cys Asp Ser Pro Asp Gly Val Met Leu Cys Gly Ser His Asp
                2725                2730                2735    
Gly Arg Glu Val Tyr Ala Val Thr His Asp Leu Thr Pro Thr Glu Gly
            2740                2745                2750        
Trp Ile Met Gln Phe Lys Ile Ser Val Gly Cys Lys Val Ser Glu Lys
        2755                2760                2765            
Ile Ala Gln Asn Gln Ile His Val Gln Tyr Ser Thr Asp Phe Gly Val
    2770                2775                2780                
Ser Trp Asn Tyr Leu Val Pro Gln Cys Leu Pro Ala Asp Pro Lys Cys
2785                2790                2795                2800
Ser Gly Ser Val Ser Gln Pro Ser Val Phe Phe Pro Thr Lys Gly Trp
                2805                2810                2815    
Lys Arg Ile Thr Tyr Pro Leu Pro Glu Ser Leu Val Gly Asn Pro Val
            2820                2825                2830        
Arg Phe Arg Phe Tyr Gln Lys Tyr Ser Asp Met Gln Trp Ala Ile Asp
        2835                2840                2845            
Asn Phe Tyr Leu Gly Pro Gly Cys Leu Asp Asn Cys Arg Gly His Gly
    2850                2855                2860                
Asp Cys Leu Arg Glu Gln Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro
2865                2870                2875                2880
Asn Cys Tyr Leu Thr His Thr Leu Lys Thr Phe Leu Lys Glu Arg Phe
                2885                2890                2895    
Asp Ser Glu Glu Ile Lys Pro Asp Leu Trp Met Ser Leu Glu Gly Gly
            2900                2905                2910        
Ser Thr Cys Thr Glu Cys Gly Ile Leu Ala Glu Asp Thr Ala Leu Tyr
        2915                2920                2925            
Phe Gly Gly Ser Thr Val Arg Gln Ala Val Thr Gln Asp Leu Asp Leu
    2930                2935                2940                
Arg Gly Ala Lys Phe Leu Gln Tyr Trp Gly Arg Ile Gly Ser Glu Asn
2945                2950                2955                2960
Asn Met Thr Ser Cys His Arg Pro Ile Cys Arg Lys Glu Gly Val Leu
                2965                2970                2975    
Leu Asp Tyr Ser Thr Asp Gly Gly Ile Thr Trp Thr Leu Leu His Glu
            2980                2985                2990        
Met Asp Tyr Gln Lys Tyr Ile Ser Val Arg His Asp Tyr Ile Leu Leu
        2995                3000                3005            
Pro Glu Asp Ala Leu Thr Asn Thr Thr Arg Leu Arg Trp Trp Gln Pro
    3010                3015                3020                
Phe Val Ile Ser Asn Gly Ile Val Val Ser Gly Val Glu Arg Ala Gln
3025                3030                3035                3040
Trp Ala Leu Asp Asn Ile Leu Ile Gly Gly Ala Glu Ile Asn Pro Ser
                3045                3050                3055    
Gln Leu Val Asp Thr Phe Asp Asp Glu Gly Thr Ser His Glu Glu Asn
            3060                3065                3070        
Trp Ser Phe Tyr Pro Asn Ala Val Arg Thr Ala Gly Phe Cys Gly Asn
        3075                3080                3085            
Pro Ser Phe His Leu Tyr Trp Pro Asn Lys Lys Lys Asp Lys Thr His
    3090                3095                3100                
Asn Ala Leu Ser Ser Arg Glu Leu Ile Ile Gln Pro Gly Tyr Met Met
3105                3110                3115                3120
Gln Phe Lys Ile Val Val Gly Cys Glu Ala Thr Ser Cys Gly Asp Leu
                3125                3130                3135    
His Ser Val Met Leu Glu Tyr Thr Lys Asp Ala Arg Ser Asp Ser Trp
            3140                3145                3150        
Gln Leu Val Gln Thr Gln Cys Leu Pro Ser Ser Ser Asn Ser Ile Gly
        3155                3160                3165            
Cys Ser Pro Phe Gln Phe His Glu Ala Thr Ile Tyr Asn Ser Val Asn
    3170                3175                3180                
Ser Ser Ser Trp Lys Arg Ile Thr Ile Gln Leu Pro Asp His Val Ser
3185                3190                3195                3200
Ser Ser Ala Thr Gln Phe Arg Trp Ile Gln Lys Gly Glu Glu Thr Glu
                3205                3210                3215    
Lys Gln Ser Trp Ala Ile Asp His Val Tyr Ile Gly Glu Ala Cys Pro
            3220                3225                3230        
Lys Leu Cys Ser Gly His Gly Tyr Cys Thr Thr Gly Ala Ile Cys Ile
        3235                3240                3245            
Cys Asp Glu Ser Phe Gln Gly Asp Asp Cys Ser Val Phe Ser His Asp
    3250                3255                3260                
Leu Pro Ser Tyr Ile Lys Asp Asn Phe Glu Ser Ala Arg Val Thr Glu
3265                3270                3275                3280
Ala Asn Trp Glu Thr Ile Gln Gly Gly Val Ile Gly Ser Gly Cys Gly
                3285                3290                3295    
Gln Leu Ala Pro Tyr Ala His Gly Asp Ser Leu Tyr Phe Asn Gly Cys
            3300                3305                3310        
Gln Ile Arg Gln Ala Ala Thr Lys Pro Leu Asp Leu Thr Arg Ala Ser
        3315                3320                3325            
Lys Ile Met Phe Val Leu Gln Ile Gly Ser Met Ser Gln Thr Asp Ser
    3330                3335                3340                
Cys Asn Ser Asp Leu Ser Gly Pro His Ala Val Asp Lys Ala Val Leu
3345                3350                3355                3360
Leu Gln Tyr Ser Val Asn Asn Gly Ile Thr Trp His Val Ile Ala Gln
                3365                3370                3375    
His Gln Pro Lys Asp Phe Thr Gln Ala Gln Arg Val Ser Tyr Asn Val
            3380                3385                3390        
Pro Leu Glu Ala Arg Met Lys Gly Val Leu Leu Arg Trp Trp Gln Pro
        3395                3400                3405            
Arg His Asn Gly Thr Gly His Asp Gln Trp Ala Leu Asp His Val Glu
    3410                3415                3420                
Val Val Leu
3425        


<210> 5930
<211> 3458
<212> PRT
<213> Homo sapiens

<400> 5930
Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg
            20                  25                  30          
Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly
        35                  40                  45              
Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn
    50                  55                  60                  
Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr
65                  70                  75                  80  
Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr
                85                  90                  95      
Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe
            100                 105                 110         
Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val
        115                 120                 125             
Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile
    130                 135                 140                 
Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr
145                 150                 155                 160 
Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln
                165                 170                 175     
Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu
            180                 185                 190         
Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser
        195                 200                 205             
Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn
    210                 215                 220                 
Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val
225                 230                 235                 240 
Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu
                245                 250                 255     
Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser
            260                 265                 270         
Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys
        275                 280                 285             
Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser
    290                 295                 300                 
Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys
305                 310                 315                 320 
Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly
                325                 330                 335     
Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn
            340                 345                 350         
Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp
        355                 360                 365             
Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys
    370                 375                 380                 
Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu
385                 390                 395                 400 
Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile
                405                 410                 415     
Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp
            420                 425                 430         
Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly
        435                 440                 445             
Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro
    450                 455                 460                 
Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met
465                 470                 475                 480 
Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu
                485                 490                 495     
Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu
            500                 505                 510         
Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn
        515                 520                 525             
Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn
    530                 535                 540                 
His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val
545                 550                 555                 560 
Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile
                565                 570                 575     
Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu
            580                 585                 590         
Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys
        595                 600                 605             
Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr
    610                 615                 620                 
Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro
625                 630                 635                 640 
Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly
                645                 650                 655     
Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro
            660                 665                 670         
Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly
        675                 680                 685             
Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser
    690                 695                 700                 
Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu
705                 710                 715                 720 
Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe
                725                 730                 735     
Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Glu
            740                 745                 750         
Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg
        755                 760                 765             
Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr
    770                 775                 780                 
Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser
785                 790                 795                 800 
Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu
                805                 810                 815     
Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala
            820                 825                 830         
Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser
        835                 840                 845             
Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val
    850                 855                 860                 
Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr
865                 870                 875                 880 
Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His
                885                 890                 895     
Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met
            900                 905                 910         
Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile
        915                 920                 925             
Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met
    930                 935                 940                 
Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp
945                 950                 955                 960 
His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu
                965                 970                 975     
Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg
            980                 985                 990         
Arg Val Ile Val Leu Leu Pro Gln Lys Thr Trp Ser Ser Ala Thr Arg
        995                 1000                1005            
Phe Arg Trp Ser Gln Ser Tyr Tyr Thr Ala Gln Asp Glu Trp Ala Leu
    1010                1015                1020                
Asp Ser Ile Tyr Ile Gly Gln Gln Cys Pro Asn Met Cys Ser Gly His
1025                1030                1035                1040
Gly Ser Cys Asp His Gly Ile Cys Arg Cys Asp Gln Gly Tyr Gln Gly
                1045                1050                1055    
Thr Glu Cys His Pro Glu Ala Ala Leu Pro Ser Thr Ile Met Ser Asp
            1060                1065                1070        
Phe Glu Asn Gln Asn Gly Trp Glu Ser Asp Trp Gln Glu Val Ile Gly
        1075                1080                1085            
Gly Glu Ile Val Lys Pro Glu Gln Gly Cys Gly Val Ile Ser Ser Gly
    1090                1095                1100                
Ser Ser Leu Tyr Phe Ser Lys Ala Gly Lys Arg Gln Leu Val Ser Trp
1105                1110                1115                1120
Asp Leu Asp Thr Ser Trp Val Asp Phe Val Gln Phe Tyr Ile Gln Ile
                1125                1130                1135    
Gly Gly Glu Ser Ala Ser Cys Asn Lys Pro Asp Ser Arg Glu Glu Gly
            1140                1145                1150        
Val Leu Leu Gln Tyr Ser Asn Asn Gly Gly Ile Gln Trp His Leu Leu
        1155                1160                1165            
Ala Glu Met Tyr Phe Ser Asp Phe Ser Lys Pro Arg Phe Val Tyr Leu
    1170                1175                1180                
Glu Leu Pro Ala Ala Ala Lys Thr Pro Cys Thr Arg Phe Arg Trp Trp
1185                1190                1195                1200
Gln Pro Val Phe Ser Gly Glu Asp Tyr Asp Gln Trp Ala Val Asp Asp
                1205                1210                1215    
Ile Ile Ile Leu Ser Glu Lys Gln Lys Gln Ile Ile Pro Val Ile Asn
            1220                1225                1230        
Pro Thr Leu Pro Gln Asn Phe Tyr Glu Lys Pro Ala Phe Asp Tyr Pro
        1235                1240                1245            
Met Asn Gln Met Ser Val Trp Leu Met Leu Ala Asn Glu Gly Met Val
    1250                1255                1260                
Lys Asn Glu Thr Phe Cys Ala Ala Thr Pro Ser Ala Met Ile Phe Gly
1265                1270                1275                1280
Lys Ser Asp Gly Asp Arg Phe Ala Val Thr Arg Asp Leu Thr Leu Lys
                1285                1290                1295    
Pro Gly Tyr Val Leu Gln Phe Lys Leu Asn Ile Gly Cys Ala Asn Gln
            1300                1305                1310        
Phe Ser Ser Thr Ala Pro Val Leu Leu Gln Tyr Ser His Asp Ala Gly
        1315                1320                1325            
Met Ser Trp Phe Leu Val Lys Glu Gly Cys Tyr Pro Ala Ser Ala Gly
    1330                1335                1340                
Lys Gly Cys Glu Gly Asn Ser Arg Glu Leu Ser Glu Pro Thr Met Tyr
1345                1350                1355                1360
His Thr Gly Asp Phe Glu Glu Trp Thr Arg Ile Thr Ile Val Ile Pro
                1365                1370                1375    
Arg Ser Leu Ala Ser Ser Lys Thr Arg Phe Arg Trp Ile Gln Glu Ser
            1380                1385                1390        
Ser Ser Gln Lys Asn Val Pro Pro Phe Gly Leu Asp Gly Val Tyr Ile
        1395                1400                1405            
Ser Glu Pro Cys Pro Ser Tyr Cys Ser Gly His Gly Asp Cys Ile Ser
    1410                1415                1420                
Gly Val Cys Phe Cys Asp Leu Gly Tyr Thr Ala Ala Gln Gly Thr Cys
1425                1430                1435                1440
Val Ser Asn Val Pro Asn His Asn Glu Met Phe Asp Arg Phe Glu Gly
                1445                1450                1455    
Lys Leu Ser Pro Leu Trp Tyr Lys Ile Thr Gly Ala Gln Val Gly Thr
            1460                1465                1470        
Gly Cys Gly Thr Leu Asn Asp Gly Lys Ser Leu Tyr Phe Asn Gly Pro
        1475                1480                1485            
Gly Lys Arg Glu Ala Arg Thr Val Pro Leu Asp Thr Arg Asn Ile Arg
    1490                1495                1500                
Leu Val Gln Phe Tyr Ile Gln Ile Gly Ser Lys Thr Ser Gly Ile Thr
1505                1510                1515                1520
Cys Ile Lys Pro Arg Thr Arg Asn Glu Gly Leu Ile Val Gln Tyr Ser
                1525                1530                1535    
Asn Asp Asn Gly Ile Leu Trp His Leu Leu Arg Glu Leu Asp Phe Met
            1540                1545                1550        
Ser Phe Leu Glu Pro Gln Ile Ile Ser Ile Asp Leu Pro Gln Asp Ala
        1555                1560                1565            
Lys Thr Pro Ala Thr Ala Phe Arg Trp Trp Gln Pro Gln His Gly Lys
    1570                1575                1580                
His Ser Ala Gln Trp Ala Leu Asp Asp Val Leu Ile Gly Met Asn Asp
1585                1590                1595                1600
Ser Ser Gln Thr Gly Phe Gln Asp Lys Phe Asp Gly Ser Ile Asp Leu
                1605                1610                1615    
Gln Ala Asn Trp Tyr Arg Ile Gln Gly Gly Gln Val Asp Ile Asp Cys
            1620                1625                1630        
Leu Ser Met Asp Thr Ala Leu Ile Phe Thr Glu Asn Ile Gly Lys Pro
        1635                1640                1645            
Arg Tyr Ala Glu Thr Trp Asp Phe His Val Ser Ala Ser Thr Phe Leu
    1650                1655                1660                
Gln Phe Glu Met Ser Met Gly Cys Ser Lys Pro Phe Ser Asn Ser His
1665                1670                1675                1680
Ser Val Gln Leu Gln Tyr Ser Leu Asn Asn Gly Lys Asp Trp His Leu
                1685                1690                1695    
Val Thr Glu Glu Cys Val Pro Pro Thr Ile Gly Cys Leu His Tyr Thr
            1700                1705                1710        
Glu Ser Ser Ile Tyr Thr Ser Glu Arg Phe Gln Asn Trp Lys Arg Ile
        1715                1720                1725            
Thr Val Tyr Leu Pro Leu Ser Thr Ile Ser Pro Arg Thr Arg Phe Arg
    1730                1735                1740                
Trp Ile Gln Ala Asn Tyr Thr Val Gly Ala Asp Ser Trp Ala Ile Asp
1745                1750                1755                1760
Asn Val Val Leu Ala Ser Gly Cys Pro Trp Met Cys Ser Gly Arg Gly
                1765                1770                1775    
Ile Cys Asp Ala Gly Arg Cys Val Cys Asp Arg Gly Phe Gly Gly Pro
            1780                1785                1790        
Tyr Cys Val Pro Val Val Pro Leu Pro Ser Ile Leu Lys Asp Asp Phe
        1795                1800                1805            
Asn Gly Asn Leu His Pro Asp Leu Trp Pro Glu Val Tyr Gly Ala Glu
    1810                1815                1820                
Arg Gly Asn Leu Asn Gly Glu Thr Ile Lys Ser Gly Thr Ser Leu Ile
1825                1830                1835                1840
Phe Lys Gly Glu Gly Leu Arg Met Leu Ile Ser Arg Asp Leu Asp Cys
                1845                1850                1855    
Thr Asn Thr Met Tyr Val Gln Phe Ser Leu Arg Phe Ile Ala Lys Ser
            1860                1865                1870        
Thr Pro Glu Arg Ser His Ser Ile Leu Leu Gln Phe Ser Ile Ser Gly
        1875                1880                1885            
Gly Ile Thr Trp His Leu Met Asp Glu Phe Tyr Phe Pro Gln Thr Thr
    1890                1895                1900                
Asn Ile Leu Phe Ile Asn Val Pro Leu Pro Tyr Thr Ala Gln Thr Asn
1905                1910                1915                1920
Ala Thr Arg Phe Arg Leu Trp Gln Pro Tyr Asn Asn Gly Lys Lys Glu
                1925                1930                1935    
Glu Ile Trp Ile Val Asp Asp Phe Ile Ile Asp Gly Asn Asn Val Asn
            1940                1945                1950        
Asn Pro Val Met Leu Leu Asp Thr Phe Asp Phe Gly Pro Arg Glu Asp
        1955                1960                1965            
Asn Trp Phe Phe Tyr Pro Gly Gly Asn Ile Gly Leu Tyr Cys Pro Tyr
    1970                1975                1980                
Ser Ser Lys Gly Ala Pro Glu Glu Asp Ser Ala Met Val Phe Val Ser
1985                1990                1995                2000
Asn Glu Val Gly Glu His Ser Ile Thr Thr Arg Asp Leu Asn Val Asn
                2005                2010                2015    
Glu Asn Thr Ile Ile Gln Phe Glu Ile Asn Val Gly Cys Ser Thr Asp
            2020                2025                2030        
Ser Ser Ser Ala Asp Pro Val Arg Leu Glu Phe Ser Arg Asp Phe Gly
        2035                2040                2045            
Ala Thr Trp His Leu Leu Leu Pro Leu Cys Tyr His Ser Ser Ser His
    2050                2055                2060                
Val Ser Ser Leu Cys Ser Thr Glu His His Pro Ser Ser Thr Tyr Tyr
2065                2070                2075                2080
Ala Gly Thr Met Gln Gly Trp Arg Arg Glu Val Val His Phe Gly Lys
                2085                2090                2095    
Leu His Leu Cys Gly Ser Val Arg Phe Arg Trp Tyr Gln Gly Phe Tyr
            2100                2105                2110        
Pro Ala Gly Ser Gln Pro Val Thr Trp Ala Ile Asp Asn Val Tyr Ile
        2115                2120                2125            
Gly Pro Gln Cys Glu Glu Met Cys Asn Gly Gln Gly Ser Cys Ile Asn
    2130                2135                2140                
Gly Thr Lys Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro Thr Cys Lys
2145                2150                2155                2160
Ile Ser Thr Lys Asn Pro Asp Phe Leu Lys Asp Asp Phe Glu Gly Gln
                2165                2170                2175    
Leu Glu Ser Asp Arg Phe Leu Leu Met Ser Gly Gly Lys Pro Ser Arg
            2180                2185                2190        
Lys Cys Gly Ile Leu Ser Ser Gly Asn Asn Leu Phe Phe Asn Glu Asp
        2195                2200                2205            
Gly Leu Arg Met Leu Met Thr Arg Asp Leu Asp Leu Ser His Ala Arg
    2210                2215                2220                
Phe Val Gln Phe Phe Met Arg Leu Gly Cys Gly Lys Gly Val Pro Asp
2225                2230                2235                2240
Pro Arg Ser Gln Pro Val Leu Leu Gln Tyr Ser Leu Asn Gly Gly Leu
                2245                2250                2255    
Ser Trp Ser Leu Leu Gln Glu Phe Leu Phe Ser Asn Ser Ser Asn Val
            2260                2265                2270        
Gly Arg Tyr Ile Ala Leu Glu Ile Pro Leu Lys Ala Arg Ser Gly Ser
        2275                2280                2285            
Thr Arg Leu Arg Trp Trp Gln Pro Ser Glu Asn Gly His Phe Tyr Ser
    2290                2295                2300                
Pro Trp Val Ile Asp Gln Ile Leu Ile Gly Gly Asn Ile Ser Gly Asn
2305                2310                2315                2320
Thr Val Leu Glu Asp Asp Phe Thr Thr Leu Asp Ser Arg Lys Trp Leu
                2325                2330                2335    
Leu His Pro Gly Gly Thr Lys Met Pro Val Cys Gly Ser Thr Gly Asp
            2340                2345                2350        
Ala Leu Val Phe Ile Glu Lys Ala Ser Thr Arg Tyr Val Val Ser Thr
        2355                2360                2365            
Asp Val Ala Val Asn Glu Asp Ser Phe Leu Gln Ile Asp Phe Ala Ala
    2370                2375                2380                
Ser Cys Ser Val Thr Asp Ser Cys Tyr Ala Ile Glu Leu Glu Tyr Ser
2385                2390                2395                2400
Val Asp Leu Gly Leu Ser Trp His Pro Leu Val Arg Asp Cys Leu Pro
                2405                2410                2415    
Thr Asn Val Glu Cys Ser Arg Tyr His Leu Gln Arg Ile Leu Val Ser
            2420                2425                2430        
Asp Thr Phe Asn Lys Trp Thr Arg Ile Thr Leu Pro Leu Pro Pro Tyr
        2435                2440                2445            
Thr Arg Ser Gln Ala Thr Arg Phe Arg Trp His Gln Pro Ala Pro Phe
    2450                2455                2460                
Asp Lys Gln Gln Thr Trp Ala Ile Asp Asn Val Tyr Ile Gly Asp Gly
2465                2470                2475                2480
Cys Ile Asp Met Cys Ser Gly His Gly Arg Cys Ile Gln Gly Asn Cys
                2485                2490                2495    
Val Cys Asp Glu Gln Trp Gly Gly Leu Tyr Cys Asp Asp Pro Glu Thr
            2500                2505                2510        
Ser Leu Pro Thr Gln Leu Lys Asp Asn Phe Asn Arg Ala Pro Ser Ser
        2515                2520                2525            
Gln Asn Trp Leu Thr Val Asn Gly Gly Lys Leu Ser Thr Val Cys Gly
    2530                2535                2540                
Ala Val Ala Ser Gly Met Ala Leu His Phe Ser Gly Gly Cys Ser Arg
2545                2550                2555                2560
Leu Leu Val Thr Val Asp Leu Asn Leu Thr Asn Ala Glu Phe Ile Gln
                2565                2570                2575    
Phe Tyr Phe Met Tyr Gly Cys Leu Ile Thr Pro Asn Asn Arg Asn Gln
            2580                2585                2590        
Gly Val Leu Leu Glu Tyr Ser Val Asn Gly Gly Ile Thr Trp Asn Leu
        2595                2600                2605            
Leu Met Glu Ile Phe Tyr Asp Gln Tyr Ser Lys Pro Gly Phe Val Asn
    2610                2615                2620                
Ile Leu Leu Pro Pro Asp Ala Lys Glu Ile Ala Thr Arg Phe Arg Trp
2625                2630                2635                2640
Trp Gln Pro Arg His Asp Gly Leu Asp Gln Asn Asp Trp Ala Ile Asp
                2645                2650                2655    
Asn Val Leu Ile Ser Gly Ser Ala Asp Gln Arg Thr Val Met Leu Asp
            2660                2665                2670        
Thr Phe Ser Ser Ala Pro Val Pro Gln His Glu Arg Ser Pro Ala Asp
        2675                2680                2685            
Ala Gly Pro Val Gly Arg Ile Ala Phe Asp Met Phe Met Glu Asp Lys
    2690                2695                2700                
Thr Ser Val Asn Glu His Trp Leu Phe His Asp Asp Cys Thr Val Glu
2705                2710                2715                2720
Arg Phe Cys Asp Ser Pro Asp Gly Val Met Leu Cys Gly Ser His Asp
                2725                2730                2735    
Gly Arg Glu Val Tyr Ala Val Thr His Asp Leu Thr Pro Thr Glu Gly
            2740                2745                2750        
Trp Ile Met Gln Phe Lys Ile Ser Val Gly Cys Lys Val Ser Glu Lys
        2755                2760                2765            
Ile Ala Gln Asn Gln Ile His Val Gln Tyr Ser Thr Asp Phe Gly Val
    2770                2775                2780                
Ser Trp Asn Tyr Leu Val Pro Gln Cys Leu Pro Ala Asp Pro Lys Cys
2785                2790                2795                2800
Ser Gly Ser Val Ser Gln Pro Ser Val Phe Phe Pro Thr Lys Gly Trp
                2805                2810                2815    
Lys Arg Ile Thr Tyr Pro Leu Pro Glu Ser Leu Val Gly Asn Pro Val
            2820                2825                2830        
Arg Phe Arg Phe Tyr Gln Lys Tyr Ser Asp Met Gln Trp Ala Ile Asp
        2835                2840                2845            
Asn Phe Tyr Leu Gly Pro Gly Cys Leu Asp Asn Cys Arg Gly His Gly
    2850                2855                2860                
Asp Cys Leu Arg Glu Gln Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro
2865                2870                2875                2880
Asn Cys Tyr Leu Thr His Thr Leu Lys Thr Phe Leu Lys Glu Arg Phe
                2885                2890                2895    
Asp Ser Glu Glu Ile Lys Pro Asp Leu Trp Met Ser Leu Glu Gly Gly
            2900                2905                2910        
Ser Thr Cys Thr Glu Cys Gly Ile Leu Ala Glu Asp Thr Ala Leu Tyr
        2915                2920                2925            
Phe Gly Gly Ser Thr Val Arg Gln Ala Val Thr Gln Asp Leu Asp Leu
    2930                2935                2940                
Arg Gly Ala Lys Phe Leu Gln Tyr Trp Gly Arg Ile Gly Ser Glu Asn
2945                2950                2955                2960
Asn Met Thr Ser Cys His Arg Pro Ile Cys Arg Lys Glu Gly Val Leu
                2965                2970                2975    
Leu Asp Tyr Ser Thr Asp Gly Gly Ile Thr Trp Thr Leu Leu His Glu
            2980                2985                2990        
Met Asp Tyr Gln Lys Tyr Ile Ser Val Arg His Asp Tyr Ile Leu Leu
        2995                3000                3005            
Pro Glu Asp Ala Leu Thr Asn Thr Thr Arg Leu Arg Trp Trp Gln Pro
    3010                3015                3020                
Phe Val Ile Ser Asn Gly Ile Val Val Ser Gly Val Glu Arg Ala Gln
3025                3030                3035                3040
Trp Ala Leu Asp Asn Ile Leu Ile Gly Gly Ala Glu Ile Asn Pro Ser
                3045                3050                3055    
Gln Leu Val Asp Thr Phe Asp Asp Glu Gly Thr Ser His Glu Glu Asn
            3060                3065                3070        
Trp Ser Phe Tyr Pro Asn Ala Val Arg Thr Ala Gly Phe Cys Gly Asn
        3075                3080                3085            
Pro Ser Phe His Leu Tyr Trp Pro Asn Lys Lys Lys Asp Lys Thr His
    3090                3095                3100                
Asn Ala Leu Ser Ser Arg Glu Leu Ile Ile Gln Pro Gly Tyr Met Met
3105                3110                3115                3120
Gln Phe Lys Ile Val Val Gly Cys Glu Ala Thr Ser Cys Gly Asp Leu
                3125                3130                3135    
His Ser Val Met Leu Glu Tyr Thr Lys Asp Ala Arg Ser Asp Ser Trp
            3140                3145                3150        
Gln Leu Val Gln Thr Gln Cys Leu Pro Ser Ser Ser Asn Ser Ile Gly
        3155                3160                3165            
Cys Ser Pro Phe Gln Phe His Glu Ala Thr Ile Tyr Asn Ser Val Asn
    3170                3175                3180                
Ser Ser Ser Trp Lys Arg Ile Thr Ile Gln Leu Pro Asp His Val Ser
3185                3190                3195                3200
Ser Ser Ala Thr Gln Phe Arg Trp Ile Gln Lys Gly Glu Glu Thr Glu
                3205                3210                3215    
Lys Gln Ser Trp Ala Ile Asp His Val Tyr Ile Gly Glu Ala Cys Pro
            3220                3225                3230        
Lys Leu Cys Ser Gly His Gly Tyr Cys Thr Thr Gly Ala Ile Cys Ile
        3235                3240                3245            
Cys Asp Glu Ser Phe Gln Gly Asp Asp Cys Ser Val Phe Ser His Asp
    3250                3255                3260                
Leu Pro Ser Tyr Ile Lys Asp Asn Phe Glu Ser Ala Arg Val Thr Glu
3265                3270                3275                3280
Ala Asn Trp Glu Thr Ile Gln Gly Gly Val Ile Gly Ser Gly Cys Gly
                3285                3290                3295    
Gln Leu Ala Pro Tyr Ala His Gly Asp Ser Leu Tyr Phe Asn Gly Cys
            3300                3305                3310        
Gln Ile Arg Gln Ala Ala Thr Lys Pro Leu Asp Leu Thr Arg Ala Ser
        3315                3320                3325            
Lys Ile Met Phe Val Leu Gln Ile Gly Ser Met Ser Gln Thr Asp Ser
    3330                3335                3340                
Cys Asn Ser Asp Leu Ser Gly Pro His Ala Val Asp Lys Ala Val Leu
3345                3350                3355                3360
Leu Gln Tyr Ser Val Asn Asn Gly Ile Thr Trp His Val Ile Ala Gln
                3365                3370                3375    
His Gln Pro Lys Asp Phe Thr Gln Ala Gln Arg Val Ser Tyr Asn Val
            3380                3385                3390        
Pro Leu Glu Ala Arg Met Lys Gly Val Leu Leu Arg Trp Trp Gln Pro
        3395                3400                3405            
Arg His Asn Gly Thr Gly His Asp Gln Trp Ala Leu Asp His Val Glu
    3410                3415                3420                
Val Val Leu Thr Arg Lys Gln Asn Tyr Met Met Asn Phe Ser Arg Gln
3425                3430                3435                3440
His Gly Leu Arg His Phe Tyr Asn Arg Arg Arg Arg Ser Leu Arg Arg
                3445                3450                3455    
Tyr Pro
        


<210> 5931
<211> 3460
<212> PRT
<213> Homo sapiens

<400> 5931
Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg
            20                  25                  30          
Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly
        35                  40                  45              
Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn
    50                  55                  60                  
Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr
65                  70                  75                  80  
Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr
                85                  90                  95      
Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe
            100                 105                 110         
Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val
        115                 120                 125             
Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile
    130                 135                 140                 
Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr
145                 150                 155                 160 
Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln
                165                 170                 175     
Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu
            180                 185                 190         
Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser
        195                 200                 205             
Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn
    210                 215                 220                 
Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val
225                 230                 235                 240 
Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu
                245                 250                 255     
Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser
            260                 265                 270         
Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys
        275                 280                 285             
Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser
    290                 295                 300                 
Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys
305                 310                 315                 320 
Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly
                325                 330                 335     
Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn
            340                 345                 350         
Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp
        355                 360                 365             
Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys
    370                 375                 380                 
Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu
385                 390                 395                 400 
Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile
                405                 410                 415     
Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp
            420                 425                 430         
Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly
        435                 440                 445             
Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro
    450                 455                 460                 
Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met
465                 470                 475                 480 
Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu
                485                 490                 495     
Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu
            500                 505                 510         
Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn
        515                 520                 525             
Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn
    530                 535                 540                 
His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val
545                 550                 555                 560 
Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile
                565                 570                 575     
Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu
            580                 585                 590         
Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys
        595                 600                 605             
Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr
    610                 615                 620                 
Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro
625                 630                 635                 640 
Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly
                645                 650                 655     
Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro
            660                 665                 670         
Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly
        675                 680                 685             
Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser
    690                 695                 700                 
Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu
705                 710                 715                 720 
Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe
                725                 730                 735     
Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Glu
            740                 745                 750         
Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg
        755                 760                 765             
Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr
    770                 775                 780                 
Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser
785                 790                 795                 800 
Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu
                805                 810                 815     
Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala
            820                 825                 830         
Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser
        835                 840                 845             
Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val
    850                 855                 860                 
Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr
865                 870                 875                 880 
Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His
                885                 890                 895     
Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met
            900                 905                 910         
Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile
        915                 920                 925             
Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met
    930                 935                 940                 
Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp
945                 950                 955                 960 
His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu
                965                 970                 975     
Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg
            980                 985                 990         
Arg Val Ile Val Leu Leu Pro Gln Lys Thr Trp Ser Ser Ala Thr Arg
        995                 1000                1005            
Phe Arg Trp Ser Gln Ser Tyr Tyr Thr Ala Gln Asp Glu Trp Ala Leu
    1010                1015                1020                
Asp Ser Ile Tyr Ile Gly Gln Gln Cys Pro Asn Met Cys Ser Gly His
1025                1030                1035                1040
Gly Ser Cys Asp His Gly Ile Cys Arg Cys Asp Gln Gly Tyr Gln Gly
                1045                1050                1055    
Thr Glu Cys His Pro Glu Ala Ala Leu Pro Ser Thr Ile Met Ser Asp
            1060                1065                1070        
Phe Glu Asn Gln Asn Gly Trp Glu Ser Asp Trp Gln Glu Val Ile Gly
        1075                1080                1085            
Gly Glu Ile Val Lys Pro Glu Gln Gly Cys Gly Val Ile Ser Ser Gly
    1090                1095                1100                
Ser Ser Leu Tyr Phe Ser Lys Ala Gly Lys Arg Gln Leu Val Ser Trp
1105                1110                1115                1120
Asp Leu Asp Thr Ser Trp Val Asp Phe Val Gln Phe Tyr Ile Gln Ile
                1125                1130                1135    
Gly Gly Glu Ser Ala Ser Cys Asn Lys Pro Asp Ser Arg Glu Glu Gly
            1140                1145                1150        
Val Leu Leu Gln Tyr Ser Asn Asn Gly Gly Ile Gln Trp His Leu Leu
        1155                1160                1165            
Ala Glu Met Tyr Phe Ser Asp Phe Ser Lys Pro Arg Phe Val Tyr Leu
    1170                1175                1180                
Glu Leu Pro Ala Ala Ala Lys Thr Pro Cys Thr Arg Phe Arg Trp Trp
1185                1190                1195                1200
Gln Pro Val Phe Ser Gly Glu Asp Tyr Asp Gln Trp Ala Val Asp Asp
                1205                1210                1215    
Ile Ile Ile Leu Ser Glu Lys Gln Lys Gln Ile Ile Pro Val Ile Asn
            1220                1225                1230        
Pro Thr Leu Pro Gln Asn Phe Tyr Glu Lys Pro Ala Phe Asp Tyr Pro
        1235                1240                1245            
Met Asn Gln Met Ser Val Trp Leu Met Leu Ala Asn Glu Gly Met Val
    1250                1255                1260                
Lys Asn Glu Thr Phe Cys Ala Ala Thr Pro Ser Ala Met Ile Phe Gly
1265                1270                1275                1280
Lys Ser Asp Gly Asp Arg Phe Ala Val Thr Arg Asp Leu Thr Leu Lys
                1285                1290                1295    
Pro Gly Tyr Val Leu Gln Phe Lys Leu Asn Ile Gly Cys Ala Asn Gln
            1300                1305                1310        
Phe Ser Ser Thr Ala Pro Val Leu Leu Gln Tyr Ser His Asp Ala Gly
        1315                1320                1325            
Met Ser Trp Phe Leu Val Lys Glu Gly Cys Tyr Pro Ala Ser Ala Gly
    1330                1335                1340                
Lys Gly Cys Glu Gly Asn Ser Arg Glu Leu Ser Glu Pro Thr Met Tyr
1345                1350                1355                1360
His Thr Gly Asp Phe Glu Glu Trp Thr Arg Ile Thr Ile Val Ile Pro
                1365                1370                1375    
Arg Ser Leu Ala Ser Ser Lys Thr Arg Phe Arg Trp Ile Gln Glu Ser
            1380                1385                1390        
Ser Ser Gln Lys Asn Val Pro Pro Phe Gly Leu Asp Gly Val Tyr Ile
        1395                1400                1405            
Ser Glu Pro Cys Pro Ser Tyr Cys Ser Gly His Gly Asp Cys Ile Ser
    1410                1415                1420                
Gly Val Cys Phe Cys Asp Leu Gly Tyr Thr Ala Ala Gln Gly Thr Cys
1425                1430                1435                1440
Val Ser Asn Val Pro Asn His Asn Glu Met Phe Asp Arg Phe Glu Gly
                1445                1450                1455    
Lys Leu Ser Pro Leu Trp Tyr Lys Ile Thr Gly Ala Gln Val Gly Thr
            1460                1465                1470        
Gly Cys Gly Thr Leu Asn Asp Gly Lys Ser Leu Tyr Phe Asn Gly Pro
        1475                1480                1485            
Gly Lys Arg Glu Ala Arg Thr Val Pro Leu Asp Thr Arg Asn Ile Arg
    1490                1495                1500                
Leu Val Gln Phe Tyr Ile Gln Ile Gly Ser Lys Thr Ser Gly Ile Thr
1505                1510                1515                1520
Cys Ile Lys Pro Arg Thr Arg Asn Glu Gly Leu Ile Val Gln Tyr Ser
                1525                1530                1535    
Asn Asp Asn Gly Ile Leu Trp His Leu Leu Arg Glu Leu Asp Phe Met
            1540                1545                1550        
Ser Phe Leu Glu Pro Gln Ile Ile Ser Ile Asp Leu Pro Gln Asp Ala
        1555                1560                1565            
Lys Thr Pro Ala Thr Ala Phe Arg Trp Trp Gln Pro Gln His Gly Lys
    1570                1575                1580                
His Ser Ala Gln Trp Ala Leu Asp Asp Val Leu Ile Gly Met Asn Asp
1585                1590                1595                1600
Ser Ser Gln Thr Gly Phe Gln Asp Lys Phe Asp Gly Ser Ile Asp Leu
                1605                1610                1615    
Gln Ala Asn Trp Tyr Arg Ile Gln Gly Gly Gln Val Asp Ile Asp Cys
            1620                1625                1630        
Leu Ser Met Asp Thr Ala Leu Ile Phe Thr Glu Asn Ile Gly Lys Pro
        1635                1640                1645            
Arg Tyr Ala Glu Thr Trp Asp Phe His Val Ser Ala Ser Thr Phe Leu
    1650                1655                1660                
Gln Phe Glu Met Ser Met Gly Cys Ser Lys Pro Phe Ser Asn Ser His
1665                1670                1675                1680
Ser Val Gln Leu Gln Tyr Ser Leu Asn Asn Gly Lys Asp Trp His Leu
                1685                1690                1695    
Val Thr Glu Glu Cys Val Pro Pro Thr Ile Gly Cys Leu His Tyr Thr
            1700                1705                1710        
Glu Ser Ser Ile Tyr Thr Ser Glu Arg Phe Gln Asn Trp Lys Arg Ile
        1715                1720                1725            
Thr Val Tyr Leu Pro Leu Ser Thr Ile Ser Pro Arg Thr Arg Phe Arg
    1730                1735                1740                
Trp Ile Gln Ala Asn Tyr Thr Val Gly Ala Asp Ser Trp Ala Ile Asp
1745                1750                1755                1760
Asn Val Val Leu Ala Ser Gly Cys Pro Trp Met Cys Ser Gly Arg Gly
                1765                1770                1775    
Ile Cys Asp Ala Gly Arg Cys Val Cys Asp Arg Gly Phe Gly Gly Pro
            1780                1785                1790        
Tyr Cys Val Pro Val Val Pro Leu Pro Ser Ile Leu Lys Asp Asp Phe
        1795                1800                1805            
Asn Gly Asn Leu His Pro Asp Leu Trp Pro Glu Val Tyr Gly Ala Glu
    1810                1815                1820                
Arg Gly Asn Leu Asn Gly Glu Thr Ile Lys Ser Gly Thr Ser Leu Ile
1825                1830                1835                1840
Phe Lys Gly Glu Gly Leu Arg Met Leu Ile Ser Arg Asp Leu Asp Cys
                1845                1850                1855    
Thr Asn Thr Met Tyr Val Gln Phe Ser Leu Arg Phe Ile Ala Lys Ser
            1860                1865                1870        
Thr Pro Glu Arg Ser His Ser Ile Leu Leu Gln Phe Ser Ile Ser Gly
        1875                1880                1885            
Gly Ile Thr Trp His Leu Met Asp Glu Phe Tyr Phe Pro Gln Thr Thr
    1890                1895                1900                
Asn Ile Leu Phe Ile Asn Val Pro Leu Pro Tyr Thr Ala Gln Thr Asn
1905                1910                1915                1920
Ala Thr Arg Phe Arg Leu Trp Gln Pro Tyr Asn Asn Gly Lys Lys Glu
                1925                1930                1935    
Glu Ile Trp Ile Val Asp Asp Phe Ile Ile Asp Gly Asn Asn Val Asn
            1940                1945                1950        
Asn Pro Val Met Leu Leu Asp Thr Phe Asp Phe Gly Pro Arg Glu Asp
        1955                1960                1965            
Asn Trp Phe Phe Tyr Pro Gly Gly Asn Ile Gly Leu Tyr Cys Pro Tyr
    1970                1975                1980                
Ser Ser Lys Gly Ala Pro Glu Glu Asp Ser Ala Met Val Phe Val Ser
1985                1990                1995                2000
Asn Glu Val Gly Glu His Ser Ile Thr Thr Arg Asp Leu Asn Val Asn
                2005                2010                2015    
Glu Asn Thr Ile Ile Gln Phe Glu Ile Asn Val Gly Cys Ser Thr Asp
            2020                2025                2030        
Ser Ser Ser Ala Asp Pro Val Arg Leu Glu Phe Ser Arg Asp Phe Gly
        2035                2040                2045            
Ala Thr Trp His Leu Leu Leu Pro Leu Cys Tyr His Ser Ser Ser His
    2050                2055                2060                
Val Ser Ser Leu Cys Ser Thr Glu His His Pro Ser Ser Thr Tyr Tyr
2065                2070                2075                2080
Ala Gly Thr Met Gln Gly Trp Arg Arg Glu Val Val His Phe Gly Lys
                2085                2090                2095    
Leu His Leu Cys Gly Ser Val Arg Phe Arg Trp Tyr Gln Gly Phe Tyr
            2100                2105                2110        
Pro Ala Gly Ser Gln Pro Val Thr Trp Ala Ile Asp Asn Val Tyr Ile
        2115                2120                2125            
Gly Pro Gln Cys Glu Glu Met Cys Asn Gly Gln Gly Ser Cys Ile Asn
    2130                2135                2140                
Gly Thr Lys Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro Thr Cys Lys
2145                2150                2155                2160
Ile Ser Thr Lys Asn Pro Asp Phe Leu Lys Asp Asp Phe Glu Gly Gln
                2165                2170                2175    
Leu Glu Ser Asp Arg Phe Leu Leu Met Ser Gly Gly Lys Pro Ser Arg
            2180                2185                2190        
Lys Cys Gly Ile Leu Ser Ser Gly Asn Asn Leu Phe Phe Asn Glu Asp
        2195                2200                2205            
Gly Leu Arg Met Leu Met Thr Arg Asp Leu Asp Leu Ser His Ala Arg
    2210                2215                2220                
Phe Val Gln Phe Phe Met Arg Leu Gly Cys Gly Lys Gly Val Pro Asp
2225                2230                2235                2240
Pro Arg Ser Gln Pro Val Leu Leu Gln Tyr Ser Leu Asn Gly Gly Leu
                2245                2250                2255    
Ser Trp Ser Leu Leu Gln Glu Phe Leu Phe Ser Asn Ser Ser Asn Val
            2260                2265                2270        
Gly Arg Tyr Ile Ala Leu Glu Ile Pro Leu Lys Ala Arg Ser Gly Ser
        2275                2280                2285            
Thr Arg Leu Arg Trp Trp Gln Pro Ser Glu Asn Gly His Phe Tyr Ser
    2290                2295                2300                
Pro Trp Val Ile Asp Gln Ile Leu Ile Gly Gly Asn Ile Ser Gly Asn
2305                2310                2315                2320
Thr Val Leu Glu Asp Asp Phe Thr Thr Leu Asp Ser Arg Lys Trp Leu
                2325                2330                2335    
Leu His Pro Gly Gly Thr Lys Met Pro Val Cys Gly Ser Thr Gly Asp
            2340                2345                2350        
Ala Leu Val Phe Ile Glu Lys Ala Ser Thr Arg Tyr Val Val Ser Thr
        2355                2360                2365            
Asp Val Ala Val Asn Glu Asp Ser Phe Leu Gln Ile Asp Phe Ala Ala
    2370                2375                2380                
Ser Cys Ser Val Thr Asp Ser Cys Tyr Ala Ile Glu Leu Glu Tyr Ser
2385                2390                2395                2400
Val Asp Leu Gly Leu Ser Trp His Pro Leu Val Arg Asp Cys Leu Pro
                2405                2410                2415    
Thr Asn Val Glu Cys Ser Arg Tyr His Leu Gln Arg Ile Leu Val Ser
            2420                2425                2430        
Asp Thr Phe Asn Lys Trp Thr Arg Ile Thr Leu Pro Leu Pro Pro Tyr
        2435                2440                2445            
Thr Arg Ser Gln Ala Thr Arg Phe Arg Trp His Gln Pro Ala Pro Phe
    2450                2455                2460                
Asp Lys Gln Gln Thr Trp Ala Ile Asp Asn Val Tyr Ile Gly Asp Gly
2465                2470                2475                2480
Cys Ile Asp Met Cys Ser Gly His Gly Arg Cys Ile Gln Gly Asn Cys
                2485                2490                2495    
Val Cys Asp Glu Gln Trp Gly Gly Leu Tyr Cys Asp Asp Pro Glu Thr
            2500                2505                2510        
Ser Leu Pro Thr Gln Leu Lys Asp Asn Phe Asn Arg Ala Pro Ser Ser
        2515                2520                2525            
Gln Asn Trp Leu Thr Val Asn Gly Gly Lys Leu Ser Thr Val Cys Gly
    2530                2535                2540                
Ala Val Ala Ser Gly Met Ala Leu His Phe Ser Gly Gly Cys Ser Arg
2545                2550                2555                2560
Leu Leu Val Thr Val Asp Leu Asn Leu Thr Asn Ala Glu Phe Ile Gln
                2565                2570                2575    
Phe Tyr Phe Met Tyr Gly Cys Leu Ile Thr Pro Asn Asn Arg Asn Gln
            2580                2585                2590        
Gly Val Leu Leu Glu Tyr Ser Val Asn Gly Gly Ile Thr Trp Asn Leu
        2595                2600                2605            
Leu Met Glu Ile Phe Tyr Asp Gln Tyr Ser Lys Pro Gly Phe Val Asn
    2610                2615                2620                
Ile Leu Leu Pro Pro Asp Ala Lys Glu Ile Ala Thr Arg Phe Arg Trp
2625                2630                2635                2640
Trp Gln Pro Arg His Asp Gly Leu Asp Gln Asn Asp Trp Ala Ile Asp
                2645                2650                2655    
Asn Val Leu Ile Ser Gly Ser Ala Asp Gln Arg Thr Val Met Leu Asp
            2660                2665                2670        
Thr Phe Ser Ser Ala Pro Val Pro Gln His Glu Arg Ser Pro Ala Asp
        2675                2680                2685            
Ala Gly Pro Val Gly Arg Ile Ala Phe Asp Met Phe Met Glu Asp Lys
    2690                2695                2700                
Thr Ser Val Asn Glu His Trp Leu Phe His Asp Asp Cys Thr Val Glu
2705                2710                2715                2720
Arg Phe Cys Asp Ser Pro Asp Gly Val Met Leu Cys Gly Ser His Asp
                2725                2730                2735    
Gly Arg Glu Val Tyr Ala Val Thr His Asp Leu Thr Pro Thr Glu Gly
            2740                2745                2750        
Trp Ile Met Gln Phe Lys Ile Ser Val Gly Cys Lys Val Ser Glu Lys
        2755                2760                2765            
Ile Ala Gln Asn Gln Ile His Val Gln Tyr Ser Thr Asp Phe Gly Val
    2770                2775                2780                
Ser Trp Asn Tyr Leu Val Pro Gln Cys Leu Pro Ala Asp Pro Lys Cys
2785                2790                2795                2800
Ser Gly Ser Val Ser Gln Pro Ser Val Phe Phe Pro Thr Lys Gly Trp
                2805                2810                2815    
Lys Arg Ile Thr Tyr Pro Leu Pro Glu Ser Leu Val Gly Asn Pro Val
            2820                2825                2830        
Arg Phe Arg Phe Tyr Gln Lys Tyr Ser Asp Met Gln Trp Ala Ile Asp
        2835                2840                2845            
Asn Phe Tyr Leu Gly Pro Gly Cys Leu Asp Asn Cys Arg Gly His Gly
    2850                2855                2860                
Asp Cys Leu Arg Glu Gln Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro
2865                2870                2875                2880
Asn Cys Tyr Leu Thr His Thr Leu Lys Thr Phe Leu Lys Glu Arg Phe
                2885                2890                2895    
Asp Ser Glu Glu Ile Lys Pro Asp Leu Trp Met Ser Leu Glu Gly Gly
            2900                2905                2910        
Ser Thr Cys Thr Glu Cys Gly Ile Leu Ala Glu Asp Thr Ala Leu Tyr
        2915                2920                2925            
Phe Gly Gly Ser Thr Val Arg Gln Ala Val Thr Gln Asp Leu Asp Leu
    2930                2935                2940                
Arg Gly Ala Lys Phe Leu Gln Tyr Trp Gly Arg Ile Gly Ser Glu Asn
2945                2950                2955                2960
Asn Met Thr Ser Cys His Arg Pro Ile Cys Arg Lys Glu Gly Val Leu
                2965                2970                2975    
Leu Asp Tyr Ser Thr Asp Gly Gly Ile Thr Trp Thr Leu Leu His Glu
            2980                2985                2990        
Met Asp Tyr Gln Lys Tyr Ile Ser Val Arg His Asp Tyr Ile Leu Leu
        2995                3000                3005            
Pro Glu Asp Ala Leu Thr Asn Thr Thr Arg Leu Arg Trp Trp Gln Pro
    3010                3015                3020                
Phe Val Ile Ser Asn Gly Ile Val Val Ser Gly Val Glu Arg Ala Gln
3025                3030                3035                3040
Trp Ala Leu Asp Asn Ile Leu Ile Gly Gly Ala Glu Ile Asn Pro Ser
                3045                3050                3055    
Gln Leu Val Asp Thr Phe Asp Asp Glu Gly Thr Ser His Glu Glu Asn
            3060                3065                3070        
Trp Ser Phe Tyr Pro Asn Ala Val Arg Thr Ala Gly Phe Cys Gly Asn
        3075                3080                3085            
Pro Ser Phe His Leu Tyr Trp Pro Asn Lys Lys Lys Asp Lys Thr His
    3090                3095                3100                
Asn Ala Leu Ser Ser Arg Glu Leu Ile Ile Gln Pro Gly Tyr Met Met
3105                3110                3115                3120
Gln Phe Lys Ile Val Val Gly Cys Glu Ala Thr Ser Cys Gly Asp Leu
                3125                3130                3135    
His Ser Val Met Leu Glu Tyr Thr Lys Asp Ala Arg Ser Asp Ser Trp
            3140                3145                3150        
Gln Leu Val Gln Thr Gln Cys Leu Pro Ser Ser Ser Asn Ser Ile Gly
        3155                3160                3165            
Cys Ser Pro Phe Gln Phe His Glu Ala Thr Ile Tyr Asn Ser Val Asn
    3170                3175                3180                
Ser Ser Ser Trp Lys Arg Ile Thr Ile Gln Leu Pro Asp His Val Ser
3185                3190                3195                3200
Ser Ser Ala Thr Gln Phe Arg Trp Ile Gln Lys Gly Glu Glu Thr Glu
                3205                3210                3215    
Lys Gln Ser Trp Ala Ile Asp His Val Tyr Ile Gly Glu Ala Cys Pro
            3220                3225                3230        
Lys Leu Cys Ser Gly His Gly Tyr Cys Thr Thr Gly Ala Ile Cys Ile
        3235                3240                3245            
Cys Asp Glu Ser Phe Gln Gly Asp Asp Cys Ser Val Phe Ser His Asp
    3250                3255                3260                
Leu Pro Ser Tyr Ile Lys Asp Asn Phe Glu Ser Ala Arg Val Thr Glu
3265                3270                3275                3280
Ala Asn Trp Glu Thr Ile Gln Gly Gly Val Ile Gly Ser Gly Cys Gly
                3285                3290                3295    
Gln Leu Ala Pro Tyr Ala His Gly Asp Ser Leu Tyr Phe Asn Gly Cys
            3300                3305                3310        
Gln Ile Arg Gln Ala Ala Thr Lys Pro Leu Asp Leu Thr Arg Ala Ser
        3315                3320                3325            
Lys Ile Met Phe Val Leu Gln Ile Gly Ser Met Ser Gln Thr Asp Ser
    3330                3335                3340                
Cys Asn Ser Asp Leu Ser Gly Pro His Ala Val Asp Lys Ala Val Leu
3345                3350                3355                3360
Leu Gln Tyr Ser Val Asn Asn Gly Ile Thr Trp His Val Ile Ala Gln
                3365                3370                3375    
His Gln Pro Lys Asp Phe Thr Gln Ala Gln Arg Val Ser Tyr Asn Val
            3380                3385                3390        
Pro Leu Glu Ala Arg Met Lys Gly Val Leu Leu Arg Trp Trp Gln Pro
        3395                3400                3405            
Arg His Asn Gly Thr Gly His Asp Gln Trp Ala Leu Asp His Val Glu
    3410                3415                3420                
Val Val Leu Val Ser Thr Arg Lys Gln Asn Tyr Met Met Asn Phe Ser
3425                3430                3435                3440
Arg Gln His Gly Leu Arg His Phe Tyr Asn Arg Arg Arg Arg Ser Leu
                3445                3450                3455    
Arg Arg Tyr Pro
            3460


<210> 5932
<211> 420
<212> PRT
<213> Homo sapiens

<400> 5932
Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala Cys
 1               5                  10                  15      
Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro
            20                  25                  30          
Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala
        35                  40                  45              
Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg
    50                  55                  60                  
Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr Phe
65                  70                  75                  80  
Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr
                85                  90                  95      
Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp
            100                 105                 110         
Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln
        115                 120                 125             
Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser
    130                 135                 140                 
Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu
145                 150                 155                 160 
Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala
                165                 170                 175     
Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg
            180                 185                 190         
Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu
        195                 200                 205             
Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe Arg
    210                 215                 220                 
Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala
225                 230                 235                 240 
Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe Leu
                245                 250                 255     
Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu
            260                 265                 270         
Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys
        275                 280                 285             
Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu
    290                 295                 300                 
Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly Ser
305                 310                 315                 320 
Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu
                325                 330                 335     
Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro
            340                 345                 350         
Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp
        355                 360                 365             
Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Met
    370                 375                 380                 
Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro Ala
385                 390                 395                 400 
Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu Val
                405                 410                 415     
Pro His His Leu
            420 


<210> 5933
<211> 657
<212> PRT
<213> Homo sapiens

<400> 5933
Met Gln Trp Arg Ala Leu Val Leu Gly Leu Val Leu Leu Arg Leu Gly
 1               5                  10                  15      
Leu His Gly Val Leu Trp Leu Val Phe Gly Leu Gly Pro Ser Met Gly
            20                  25                  30          
Phe Tyr Gln Arg Phe Pro Leu Ser Phe Gly Phe Gln Arg Leu Arg Ser
        35                  40                  45              
Pro Asp Gly Pro Ala Ser Pro Thr Ser Gly Pro Val Gly Arg Pro Gly
    50                  55                  60                  
Gly Val Ser Gly Pro Ser Trp Leu Gln Pro Pro Gly Thr Gly Ala Ala
65                  70                  75                  80  
Gln Ser Pro Arg Lys Ala Pro Arg Arg Pro Gly Pro Gly Met Cys Gly
                85                  90                  95      
Pro Ala Asn Trp Gly Tyr Val Leu Gly Gly Arg Gly Arg Gly Pro Asp
            100                 105                 110         
Glu Tyr Glu Lys Arg Tyr Ser Gly Ala Phe Pro Pro Gln Leu Arg Ala
        115                 120                 125             
Gln Met Arg Asp Leu Ala Arg Gly Met Phe Val Phe Gly Tyr Asp Asn
    130                 135                 140                 
Tyr Met Ala His Ala Phe Pro Gln Asp Glu Leu Asn Pro Ile His Cys
145                 150                 155                 160 
Arg Gly Arg Gly Pro Asp Arg Gly Asp Pro Ser Asn Leu Asn Ile Asn
                165                 170                 175     
Asp Val Leu Gly Asn Tyr Ser Leu Thr Leu Val Asp Ala Leu Asp Thr
            180                 185                 190         
Leu Ala Ile Met Gly Asn Ser Ser Glu Phe Gln Lys Ala Val Lys Leu
        195                 200                 205             
Val Ile Asn Thr Val Ser Phe Asp Lys Asp Ser Thr Val Gln Val Phe
    210                 215                 220                 
Glu Ala Thr Ile Arg Val Leu Gly Ser Leu Leu Ser Ala His Arg Ile
225                 230                 235                 240 
Ile Thr Asp Ser Lys Gln Pro Phe Gly Asp Met Thr Ile Lys Asp Tyr
                245                 250                 255     
Asp Asn Glu Leu Leu Tyr Met Ala His Asp Leu Ala Val Arg Leu Leu
            260                 265                 270         
Pro Ala Phe Glu Asn Thr Lys Thr Gly Ile Pro Tyr Pro Arg Val Asn
        275                 280                 285             
Leu Lys Thr Gly Val Pro Pro Asp Thr Asn Asn Glu Thr Cys Thr Ala
    290                 295                 300                 
Gly Ala Gly Ser Leu Leu Val Glu Phe Gly Ile Leu Ser Arg Leu Leu
305                 310                 315                 320 
Gly Asp Ser Thr Phe Glu Trp Val Ala Arg Arg Ala Val Lys Ala Leu
                325                 330                 335     
Trp Asn Leu Arg Ser Asn Asp Thr Gly Leu Leu Gly Asn Val Val Asn
            340                 345                 350         
Ile Gln Thr Gly His Trp Val Gly Lys Gln Ser Gly Leu Gly Ala Gly
        355                 360                 365             
Leu Asp Ser Phe Tyr Glu Tyr Leu Leu Lys Ser Tyr Ile Leu Phe Gly
    370                 375                 380                 
Glu Lys Glu Asp Leu Glu Met Phe Asn Ala Ala Tyr Gln Ser Ile Gln
385                 390                 395                 400 
Asn Tyr Leu Arg Arg Gly Arg Glu Ala Cys Asn Glu Gly Glu Gly Asp
                405                 410                 415     
Pro Pro Leu Tyr Val Asn Val Asn Met Phe Ser Gly Gln Leu Met Asn
            420                 425                 430         
Thr Trp Ile Asp Ser Leu Gln Ala Phe Phe Pro Gly Leu Gln Val Leu
        435                 440                 445             
Ile Gly Asp Val Glu Asp Ala Ile Cys Leu His Ala Phe Tyr Tyr Ala
    450                 455                 460                 
Ile Trp Lys Arg Tyr Gly Ala Leu Pro Glu Arg Tyr Asn Trp Gln Leu
465                 470                 475                 480 
Gln Ala Pro Asp Val Leu Phe Tyr Pro Leu Arg Pro Glu Leu Val Glu
                485                 490                 495     
Ser Thr Tyr Leu Leu Tyr Gln Ala Thr Lys Asn Pro Phe Tyr Leu His
            500                 505                 510         
Val Gly Met Asp Ile Leu Gln Ser Leu Glu Lys Tyr Thr Lys Val Lys
        515                 520                 525             
Cys Gly Tyr Ala Thr Leu His His Val Ile Asp Lys Ser Thr Glu Asp
    530                 535                 540                 
Arg Met Glu Ser Phe Phe Leu Ser Glu Thr Cys Lys Tyr Leu Tyr Leu
545                 550                 555                 560 
Leu Phe Asp Glu Asp Asn Pro Val His Lys Ser Gly Thr Arg Tyr Met
                565                 570                 575     
Phe Thr Thr Glu Gly His Ile Val Ser Val Asp Glu His Leu Arg Glu
            580                 585                 590         
Leu Pro Trp Lys Glu Phe Phe Ser Glu Glu Gly Gly Gln Asp Gln Gly
        595                 600                 605             
Gly Lys Ser Val His Arg Pro Lys Pro His Glu Leu Lys Val Ile Asn
    610                 615                 620                 
Ser Ser Ser Asn Cys Asn Arg Val Pro Asp Glu Arg Arg Tyr Ser Leu
625                 630                 635                 640 
Pro Leu Lys Ser Ile Tyr Met Arg Gln Ile Asp Gln Met Val Gly Leu
                645                 650                 655     
Ile
    


<210> 5934
<211> 336
<212> PRT
<213> Homo sapiens

<400> 5934
Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu
 1               5                  10                  15      
Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr
            20                  25                  30          
His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu
        35                  40                  45              
Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala
    50                  55                  60                  
Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp
65                  70                  75                  80  
Met Ala Ser Ile Ala Ser Ala Pro Thr Ser Glu Glu Val Val Gln Lys
                85                  90                  95      
Met Thr Gly Leu Lys Val Pro Leu Ser His Ser Arg Ser Asn Asp Thr
            100                 105                 110         
Leu Tyr Ile Pro Glu Trp Glu Gly Arg Ala Pro Asp Ser Val Asp Tyr
        115                 120                 125             
Arg Lys Lys Gly Tyr Val Thr Pro Val Lys Asn Gln Gly Gln Cys Gly
    130                 135                 140                 
Ser Cys Trp Ala Phe Ser Ser Val Gly Ala Leu Glu Gly Gln Leu Lys
145                 150                 155                 160 
Lys Lys Thr Gly Lys Leu Leu Asn Leu Ser Pro Gln Asn Leu Val Asp
                165                 170                 175     
Cys Val Ser Glu Asn Asp Gly Cys Gly Gly Gly Tyr Met Thr Asn Ala
            180                 185                 190         
Phe Gln Tyr Val Gln Lys Asn Arg Gly Ile Asp Ser Glu Asp Ala Tyr
        195                 200                 205             
Pro Tyr Val Gly Gln Glu Glu Ser Cys Met Tyr Asn Pro Thr Gly Lys
    210                 215                 220                 
Ala Ala Lys Cys Arg Gly Tyr Arg Glu Ile Pro Glu Gly Asn Glu Lys
225                 230                 235                 240 
Ala Leu Lys Arg Ala Val Ala Arg Val Gly Pro Val Ser Val Ala Ile
                245                 250                 255     
Asp Ala Ser Leu Thr Ser Phe Gln Phe Tyr Ser Lys Gly Val Tyr Tyr
            260                 265                 270         
Asp Glu Ser Cys Asn Ser Asp Asn Leu Asn His Ala Val Leu Ala Val
        275                 280                 285             
Gly Tyr Gly Ile Gln Lys Gly Asn Lys His Trp Ile Ile Lys Asn Ser
    290                 295                 300                 
Trp Gly Glu Asn Trp Gly Asn Lys Gly Tyr Ile Leu Met Ala Arg Asn
305                 310                 315                 320 
Lys Asn Asn Ala Cys Gly Ile Ala Asn Leu Ala Ser Phe Pro Lys Met
                325                 330                 335     


<210> 5935
<211> 1363
<212> PRT
<213> Homo sapiens

<400> 5935
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285             
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300                 
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320 
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335     
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350         
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365             
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380                 
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400 
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415     
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430         
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445             
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460                 
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480 
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495     
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510         
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525             
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540                 
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560 
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575     
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590         
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605             
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620                 
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640 
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655     
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670         
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685             
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700                 
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720 
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735     
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750         
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765             
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780                 
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800 
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815     
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830         
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845             
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860                 
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880 
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895     
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910         
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925             
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940                 
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960 
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975     
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990         
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005            
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020                
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055    
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070        
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085            
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100                
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135    
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150        
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165            
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180                
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215    
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230        
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245            
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260                
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295    
Phe Ser Cys Lys Gly Pro Gly Gln Asn Val Ala Val Thr Arg Ala His
            1300                1305                1310        
Pro Asp Ser Gln Gly Arg Arg Arg Arg Pro Glu Arg Gly Ala Arg Gly
        1315                1320                1325            
Gly Gln Val Phe Tyr Asn Ser Glu Tyr Gly Glu Leu Ser Glu Pro Ser
    1330                1335                1340                
Glu Glu Asp His Cys Ser Pro Ser Ala Arg Val Thr Phe Phe Thr Asp
1345                1350                1355                1360
Asn Ser Tyr
            


<210> 5936
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 5936
Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly
 1               5                  10                  15      
Leu Leu Asp Gly Leu Val Ser Asp Tyr Ser Met Thr Pro Pro Thr Leu
            20                  25                  30          
Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser
        35                  40                  45              
Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala
    50                  55                  60                  
Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val
65                  70                  75                  80  
Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu
                85                  90                  95      
Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr
            100                 105                 110         
Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser
        115                 120                 125             
Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp
    130                 135                 140                 
Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val
145                 150                 155                 160 
Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu
                165                 170                 175     
Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu
            180                 185                 190         
Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr
        195                 200                 205             
Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile
    210                 215                 220                 
Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu
225                 230                 235                 240 
Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala
                245                 250                 255     
Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln
            260                 265                 270         
Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His
        275                 280                 285             
Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp
    290                 295                 300                 
Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg
305                 310                 315                 320 
Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu
                325                 330                 335     
Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val
            340                 345                 350         
Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp
        355                 360                 365             
Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu
    370                 375                 380                 
Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala
385                 390                 395                 400 
Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu
                405                 410                 415     
Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro
            420                 425                 430         
Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr
        435                 440                 445             
Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr
    450                 455                 460                 
Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln
465                 470                 475                 480 
Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp
                485                 490                 495     
Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu
            500                 505                 510         
Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val
        515                 520                 525             
Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu
    530                 535                 540                 
Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile
545                 550                 555                 560 
Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu
                565                 570                 575     
Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg
            580                 585                 590         
Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu
        595                 600                 605             
Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu
    610                 615                 620                 
Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile
625                 630                 635                 640 
Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln
                645                 650                 655     
Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val
            660                 665                 670         
Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu
        675                 680                 685             
Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala
    690                 695                 700                 
His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu
705                 710                 715                 720 
Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln
                725                 730                 735     
Arg Val Arg Glu Glu Asp Ala Gly Pro Tyr Leu Cys Ser Val Cys Arg
            740                 745                 750         
Pro Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser
        755                 760                 765             
Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val
    770                 775                 780                 
Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met
785                 790                 795                 800 
Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile
                805                 810                 815     
Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser
            820                 825                 830         
Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly
        835                 840                 845             
Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala
    850                 855                 860                 
Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met
865                 870                 875                 880 
Leu Lys Glu Gly Ala Thr Ala Ser Glu Gln Arg Ala Leu Met Ser Glu
                885                 890                 895     
Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu
            900                 905                 910         
Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu
        915                 920                 925             
Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp
    930                 935                 940                 
Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe
945                 950                 955                 960 
Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser
                965                 970                 975     
Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala
            980                 985                 990         
Arg Arg Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro
        995                 1000                1005            
Leu Thr Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly
    1010                1015                1020                
Met Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala
1025                1030                1035                1040
Arg Asn Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe
                1045                1050                1055    
Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly
            1060                1065                1070        
Ser Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp
        1075                1080                1085            
Lys Val Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    1090                1095                1100                
Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Gln Ile
1105                1110                1115                1120
Asn Glu Glu Phe Cys Gln Arg Val Arg Asp Gly Thr Arg Met Arg Ala
                1125                1130                1135    
Pro Glu Leu Ala Thr Pro Ala Ile Arg His Ile Met Leu Asn Cys Trp
            1140                1145                1150        
Ser Gly Asp Pro Lys Ala Arg Pro Ala Phe Ser Glu Leu Val Glu Ile
        1155                1160                1165            
Leu Gly Asp Leu Leu Gln Gly Arg Gly Leu Gln Glu Glu Glu Glu Val
    1170                1175                1180                
Cys Met Ala Pro Arg Ser Ser Gln Ser Ser Glu Glu Gly Ser Phe Ser
1185                1190                1195                1200
Gln Val Ser Thr Met Ala Leu His Ile Ala Gln Ala Asp Ala Glu Asp
                1205                1210                1215    
Ser Pro Pro Ser Leu Gln Arg His Ser Leu Ala Ala Arg Tyr Tyr Asn
            1220                1225                1230        
Trp Val Ser Phe Pro Gly Cys Leu Ala Arg Gly Ala Glu Thr Arg Gly
        1235                1240                1245            
Ser Ser Arg Met Lys Thr Phe Glu Glu Phe Pro Met Thr Pro Thr Thr
    1250                1255                1260                
Tyr Lys Gly Ser Val Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
1265                1270                1275                1280
Ser Glu Glu Phe Glu Gln Ile Glu Ser Arg His Arg Gln Glu Ser Gly
                1285                1290                1295    
Phe Arg
        


<210> 5937
<211> 679
<212> PRT
<213> Homo sapiens

<400> 5937
Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala
 1               5                  10                  15      
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly
            20                  25                  30          
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser
        35                  40                  45              
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn
    50                  55                  60                  
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn
65                  70                  75                  80  
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp
                85                  90                  95      
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn
            100                 105                 110         
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr
        115                 120                 125             
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile
    130                 135                 140                 
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu
145                 150                 155                 160 
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu
                165                 170                 175     
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr
            180                 185                 190         
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala
        195                 200                 205             
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr
    210                 215                 220                 
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile
225                 230                 235                 240 
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu
                245                 250                 255     
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe
            260                 265                 270         
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys
        275                 280                 285             
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala
    290                 295                 300                 
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser
305                 310                 315                 320 
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser
                325                 330                 335     
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu
            340                 345                 350         
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys
        355                 360                 365             
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile
    370                 375                 380                 
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln
385                 390                 395                 400 
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala
                405                 410                 415     
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val
            420                 425                 430         
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu
        435                 440                 445             
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile
    450                 455                 460                 
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr
465                 470                 475                 480 
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp
                485                 490                 495     
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro
            500                 505                 510         
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly
        515                 520                 525             
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln
    530                 535                 540                 
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn
545                 550                 555                 560 
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys
                565                 570                 575     
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr
            580                 585                 590         
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys
        595                 600                 605             
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg
    610                 615                 620                 
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu
625                 630                 635                 640 
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala
                645                 650                 655     
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu
            660                 665                 670         
Asp Gln Lys Glu Glu Lys Gln
        675                 


<210> 5938
<211> 374
<212> PRT
<213> Homo sapiens

<400> 5938
Met Gly Leu Pro Arg Gly Ser Phe Phe Trp Leu Leu Leu Leu Leu Thr
 1               5                  10                  15      
Ala Ala Cys Ser Gly Leu Leu Phe Ala Leu Tyr Phe Ser Ala Val Gln
            20                  25                  30          
Arg Tyr Pro Gly Pro Ala Ala Gly Ala Arg Asp Thr Thr Ser Phe Glu
        35                  40                  45              
Ala Phe Phe Gln Ser Lys Ala Ser Asn Ser Trp Thr Gly Lys Gly Gln
    50                  55                  60                  
Ala Cys Arg His Leu Leu His Leu Ala Ile Gln Arg His Pro His Phe
65                  70                  75                  80  
Arg Gly Leu Phe Asn Leu Ser Ile Pro Val Leu Leu Trp Gly Asp Leu
                85                  90                  95      
Phe Thr Pro Ala Leu Trp Asp Arg Leu Ser Gln His Lys Ala Pro Tyr
            100                 105                 110         
Gly Trp Arg Gly Leu Ser His Gln Val Ile Ala Ser Thr Leu Ser Leu
        115                 120                 125             
Leu Asn Gly Ser Glu Ser Ala Lys Leu Phe Ala Pro Pro Arg Asp Thr
    130                 135                 140                 
Pro Pro Lys Cys Ile Arg Cys Ala Val Val Gly Asn Gly Gly Ile Leu
145                 150                 155                 160 
Asn Gly Ser Arg Gln Gly Pro Asn Ile Asp Ala His Asp Tyr Val Phe
                165                 170                 175     
Arg Leu Asn Gly Ala Val Ile Lys Gly Phe Glu Arg Asp Val Gly Thr
            180                 185                 190         
Lys Thr Ser Phe Tyr Gly Phe Thr Val Asn Thr Met Lys Asn Ser Leu
        195                 200                 205             
Val Ser Tyr Trp Asn Leu Gly Phe Thr Ser Val Pro Gln Gly Gln Asp
    210                 215                 220                 
Leu Gln Tyr Ile Phe Ile Pro Ser Asp Ile Arg Asp Tyr Val Met Leu
225                 230                 235                 240 
Arg Ser Ala Ile Leu Gly Val Pro Val Pro Glu Gly Leu Asp Lys Gly
                245                 250                 255     
Asp Arg Pro His Ala Tyr Phe Gly Pro Glu Ala Ser Ala Ser Lys Phe
            260                 265                 270         
Lys Leu Leu His Pro Asp Phe Ile Ser Tyr Leu Thr Glu Arg Phe Leu
        275                 280                 285             
Lys Ser Lys Leu Ile Asn Thr His Phe Gly Asp Leu Tyr Met Pro Ser
    290                 295                 300                 
Thr Gly Ala Leu Met Leu Leu Thr Ala Leu His Thr Cys Asp Gln Val
305                 310                 315                 320 
Ser Ala Tyr Gly Phe Ile Thr Ser Asn Tyr Trp Lys Phe Ser Asp His
                325                 330                 335     
Tyr Phe Glu Arg Lys Met Lys Pro Leu Ile Phe Tyr Ala Asn His Asp
            340                 345                 350         
Leu Ser Leu Glu Ala Ala Leu Trp Arg Asp Leu His Lys Ala Gly Ile
        355                 360                 365             
Leu Gln Leu Tyr Gln Arg
    370                 


<210> 5939
<211> 408
<212> PRT
<213> Homo sapiens

<400> 5939
Met Ser Lys Arg Asp Ile Val Leu Thr Asn Val Thr Val Val Gln Leu
 1               5                  10                  15      
Leu Arg Gln Pro Cys Pro Val Thr Arg Ala Pro Pro Pro Pro Glu Pro
            20                  25                  30          
Lys Ala Glu Val Glu Pro Gln Pro Gln Pro Glu Pro Thr Pro Val Arg
        35                  40                  45              
Glu Glu Ile Lys Pro Pro Pro Pro Pro Leu Pro Pro His Pro Ala Thr
    50                  55                  60                  
Pro Pro Pro Lys Met Val Ser Val Ala Arg Glu Leu Thr Val Gly Ile
65                  70                  75                  80  
Asn Gly Phe Gly Arg Ile Gly Arg Leu Val Leu Arg Ala Cys Met Glu
                85                  90                  95      
Lys Gly Val Lys Val Val Ala Val Asn Asp Pro Phe Ile Asp Pro Glu
            100                 105                 110         
Tyr Met Val Tyr Met Phe Lys Tyr Asp Ser Thr His Gly Arg Tyr Lys
        115                 120                 125             
Gly Ser Val Glu Phe Arg Asn Gly Gln Leu Val Val Asp Asn His Glu
    130                 135                 140                 
Ile Ser Val Tyr Gln Cys Lys Glu Pro Lys Gln Ile Pro Trp Arg Ala
145                 150                 155                 160 
Val Gly Ser Pro Tyr Val Val Glu Ser Thr Gly Val Tyr Leu Ser Ile
                165                 170                 175     
Gln Ala Ala Ser Asp His Ile Ser Ala Gly Ala Gln Arg Val Val Ile
            180                 185                 190         
Ser Ala Pro Ser Pro Asp Ala Pro Met Phe Val Met Gly Val Asn Glu
        195                 200                 205             
Asn Asp Tyr Asn Pro Gly Ser Met Asn Ile Val Ser Asn Ala Ser Cys
    210                 215                 220                 
Thr Thr Asn Cys Leu Ala Pro Leu Ala Lys Val Ile His Glu Arg Phe
225                 230                 235                 240 
Gly Ile Val Glu Gly Leu Met Thr Thr Val His Ser Tyr Thr Ala Thr
                245                 250                 255     
Gln Lys Thr Val Asp Gly Pro Ser Arg Lys Ala Trp Arg Asp Gly Arg
            260                 265                 270         
Gly Ala His Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala
        275                 280                 285             
Val Thr Lys Val Ile Pro Glu Leu Lys Gly Lys Leu Thr Gly Met Ala
    290                 295                 300                 
Phe Arg Val Pro Thr Pro Asp Val Ser Val Val Asp Leu Thr Cys Arg
305                 310                 315                 320 
Leu Ala Gln Pro Ala Pro Tyr Ser Ala Ile Lys Glu Ala Val Lys Ala
                325                 330                 335     
Ala Ala Lys Gly Pro Met Ala Gly Ile Leu Ala Tyr Thr Glu Asp Glu
            340                 345                 350         
Val Val Ser Thr Asp Phe Leu Gly Asp Thr His Ser Ser Ile Phe Asp
        355                 360                 365             
Ala Lys Ala Gly Ile Ala Leu Asn Asp Asn Phe Val Lys Leu Ile Ser
    370                 375                 380                 
Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser His Arg Val Val Asp Leu Leu
385                 390                 395                 400 
Arg Tyr Met Phe Ser Arg Asp Lys
                405             


<210> 5940
<211> 212
<212> PRT
<213> Homo sapiens

<400> 5940
Met Ala Ala Pro Pro Gln Leu Arg Ala Leu Leu Val Val Val Asn Ala
 1               5                  10                  15      
Leu Leu Arg Lys Arg Arg Tyr His Ala Ala Leu Ala Val Leu Lys Gly
            20                  25                  30          
Phe Arg Asn Gly Ala Val Tyr Gly Ala Lys Ile Arg Ala Pro His Ala
        35                  40                  45              
Leu Val Met Thr Phe Leu Phe Arg Asn Gly Ser Leu Gln Glu Lys Leu
    50                  55                  60                  
Trp Ala Ile Leu Gln Ala Thr Tyr Ile His Ser Trp Asn Leu Ala Arg
65                  70                  75                  80  
Phe Val Phe Thr Tyr Lys Gly Leu Arg Ala Leu Gln Ser Tyr Ile Gln
                85                  90                  95      
Gly Lys Thr Tyr Pro Ala His Ala Phe Leu Ala Ala Phe Leu Gly Gly
            100                 105                 110         
Ile Leu Val Phe Gly Glu Asn Asn Asn Ile Asn Ser Gln Ile Asn Met
        115                 120                 125             
Tyr Leu Leu Ser Arg Val Leu Phe Ala Leu Ser Arg Leu Ala Val Glu
    130                 135                 140                 
Lys Gly Tyr Ile Pro Glu Pro Arg Trp Asp Pro Phe Pro Leu Leu Thr
145                 150                 155                 160 
Ala Val Val Trp Gly Leu Val Leu Trp Leu Phe Glu Tyr His Arg Ser
                165                 170                 175     
Thr Leu Gln Pro Ser Leu Gln Ser Ser Met Thr Tyr Leu Tyr Glu Asp
            180                 185                 190         
Ser Asn Val Trp His Asp Ile Ser Asp Phe Leu Val Tyr Asn Lys Ser
        195                 200                 205             
Arg Pro Ser Asn
    210         


<210> 5941
<211> 251
<212> PRT
<213> Homo sapiens

<400> 5941
Met Ile Tyr Thr Met Lys Lys Val His Ala Leu Trp Ala Ser Val Cys
 1               5                  10                  15      
Leu Leu Leu Asn Leu Ala Pro Ala Pro Leu Asn Ala Asp Ser Glu Glu
            20                  25                  30          
Asp Glu Glu His Thr Ile Ile Thr Asp Thr Glu Leu Pro Pro Leu Lys
        35                  40                  45              
Leu Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Lys
    50                  55                  60                  
Ala Ile Met Lys Arg Phe Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu
65                  70                  75                  80  
Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn Arg Phe Glu Ser
                85                  90                  95      
Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp Asn Ala Asn Arg Ile
            100                 105                 110         
Ile Lys Thr Thr Leu Gln Gln Glu Lys Pro Asp Phe Cys Phe Leu Glu
        115                 120                 125             
Glu Asp Pro Gly Ile Cys Arg Gly Tyr Ile Thr Arg Tyr Phe Tyr Asn
    130                 135                 140                 
Asn Gln Thr Lys Gln Cys Glu Arg Phe Lys Tyr Gly Gly Cys Leu Gly
145                 150                 155                 160 
Asn Met Asn Asn Phe Glu Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu
                165                 170                 175     
Asp Gly Pro Asn Gly Phe Gln Val Asp Asn Tyr Gly Thr Gln Leu Asn
            180                 185                 190         
Ala Val Asn Asn Ser Leu Thr Pro Gln Ser Thr Lys Val Pro Ser Leu
        195                 200                 205             
Phe Val Thr Lys Glu Gly Thr Asn Asp Gly Trp Lys Asn Ala Ala His
    210                 215                 220                 
Ile Tyr Gln Val Phe Leu Asn Ala Phe Cys Ile His Ala Ser Met Phe
225                 230                 235                 240 
Phe Leu Gly Leu Asp Ser Ile Ser Cys Leu Cys
                245                 250     


<210> 5942
<211> 304
<212> PRT
<213> Homo sapiens

<400> 5942
Met Ile Tyr Thr Met Lys Lys Val His Ala Leu Trp Ala Ser Val Cys
 1               5                  10                  15      
Leu Leu Leu Asn Leu Ala Pro Ala Pro Leu Asn Ala Asp Ser Glu Glu
            20                  25                  30          
Asp Glu Glu His Thr Ile Ile Thr Asp Thr Glu Leu Pro Pro Leu Lys
        35                  40                  45              
Leu Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Lys
    50                  55                  60                  
Ala Ile Met Lys Arg Phe Phe Phe Asn Ile Phe Thr Arg Gln Cys Glu
65                  70                  75                  80  
Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn Arg Phe Glu Ser
                85                  90                  95      
Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp Asn Ala Asn Arg Ile
            100                 105                 110         
Ile Lys Thr Thr Leu Gln Gln Glu Lys Pro Asp Phe Cys Phe Leu Glu
        115                 120                 125             
Glu Asp Pro Gly Ile Cys Arg Gly Tyr Ile Thr Arg Tyr Phe Tyr Asn
    130                 135                 140                 
Asn Gln Thr Lys Gln Cys Glu Arg Phe Lys Tyr Gly Gly Cys Leu Gly
145                 150                 155                 160 
Asn Met Asn Asn Phe Glu Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu
                165                 170                 175     
Asp Gly Pro Asn Gly Phe Gln Val Asp Asn Tyr Gly Thr Gln Leu Asn
            180                 185                 190         
Ala Val Asn Asn Ser Leu Thr Pro Gln Ser Thr Lys Val Pro Ser Leu
        195                 200                 205             
Phe Glu Phe His Gly Pro Ser Trp Cys Leu Thr Pro Ala Asp Arg Gly
    210                 215                 220                 
Leu Cys Arg Ala Asn Glu Asn Arg Phe Tyr Tyr Asn Ser Val Ile Gly
225                 230                 235                 240 
Lys Cys Arg Pro Phe Lys Tyr Ser Gly Cys Gly Gly Asn Glu Asn Asn
                245                 250                 255     
Phe Thr Ser Lys Gln Glu Cys Leu Arg Ala Cys Lys Lys Gly Phe Ile
            260                 265                 270         
Gln Arg Ile Ser Lys Gly Gly Leu Ile Lys Thr Lys Arg Lys Arg Lys
        275                 280                 285             
Lys Gln Arg Val Lys Ile Ala Tyr Glu Glu Ile Phe Val Lys Asn Met
    290                 295                 300                 


<210> 5943
<211> 1224
<212> PRT
<213> Homo sapiens

<400> 5943
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe
 1               5                  10                  15      
Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln
            20                  25                  30          
Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro
        35                  40                  45              
Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu
    50                  55                  60                  
Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp
65                  70                  75                  80  
His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn
                85                  90                  95      
Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser
            100                 105                 110         
Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro
        115                 120                 125             
Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu
    130                 135                 140                 
Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro
145                 150                 155                 160 
Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln
                165                 170                 175     
Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn
            180                 185                 190         
Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe
        195                 200                 205             
Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val
    210                 215                 220                 
Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Thr Glu Ile Gly
225                 230                 235                 240 
Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro
                245                 250                 255     
Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu
            260                 265                 270         
Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val
        275                 280                 285             
Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Ala Lys
    290                 295                 300                 
Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp
305                 310                 315                 320 
Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr
                325                 330                 335     
His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys
            340                 345                 350         
Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys
        355                 360                 365             
Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly
    370                 375                 380                 
Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg
385                 390                 395                 400 
Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln
                405                 410                 415     
Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile
            420                 425                 430         
Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn
        435                 440                 445             
Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe
    450                 455                 460                 
Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys
465                 470                 475                 480 
Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln
                485                 490                 495     
Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val
            500                 505                 510         
Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg
        515                 520                 525             
Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys
    530                 535                 540                 
Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu
545                 550                 555                 560 
Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu
                565                 570                 575     
Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu
            580                 585                 590         
Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser
        595                 600                 605             
Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val
    610                 615                 620                 
Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln
625                 630                 635                 640 
Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser
                645                 650                 655     
Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro
            660                 665                 670         
Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val
        675                 680                 685             
Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala
    690                 695                 700                 
Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His
705                 710                 715                 720 
Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val
                725                 730                 735     
Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys
            740                 745                 750         
Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys
        755                 760                 765             
Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His
    770                 775                 780                 
Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys
785                 790                 795                 800 
Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val
                805                 810                 815     
Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His
            820                 825                 830         
Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr
        835                 840                 845             
Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn
    850                 855                 860                 
Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu
865                 870                 875                 880 
Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro
                885                 890                 895     
Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn
            900                 905                 910         
Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro
        915                 920                 925             
Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp
    930                 935                 940                 
Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly
945                 950                 955                 960 
Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr
                965                 970                 975     
Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro
            980                 985                 990         
Ser Trp His Leu Ser Asn Leu Asn Ala Thr Thr Lys Tyr Lys Phe Tyr
        995                 1000                1005            
Leu Arg Ala Cys Thr Ser Gln Gly Cys Gly Lys Pro Ile Thr Glu Glu
    1010                1015                1020                
Ser Ser Thr Leu Gly Glu Gly Ser Lys Gly Ile Gly Lys Ile Ser Gly
1025                1030                1035                1040
Val Asn Leu Thr Gln Lys Thr His Pro Val Glu Val Phe Glu Pro Gly
                1045                1050                1055    
Ala Glu His Ile Val Arg Leu Met Thr Lys Asn Trp Gly Asp Asn Asp
            1060                1065                1070        
Ser Ile Phe Gln Asp Val Ile Glu Thr Arg Gly Arg Glu Tyr Ala Gly
        1075                1080                1085            
Leu Tyr Asp Asp Ile Ser Thr Gln Gly Trp Phe Ile Gly Leu Met Cys
    1090                1095                1100                
Ala Ile Ala Leu Leu Thr Leu Leu Leu Leu Thr Val Cys Phe Val Lys
1105                1110                1115                1120
Arg Asn Arg Gly Gly Lys Tyr Ser Val Lys Glu Lys Glu Asp Leu His
                1125                1130                1135    
Pro Asp Pro Glu Ile Gln Ser Val Lys Asp Glu Thr Phe Gly Glu Tyr
            1140                1145                1150        
Ser Asp Ser Asp Glu Lys Pro Leu Lys Gly Ser Leu Arg Ser Leu Asn
        1155                1160                1165            
Arg Asp Met Gln Pro Thr Glu Ser Ala Asp Ser Leu Val Glu Tyr Gly
    1170                1175                1180                
Glu Gly Asp His Gly Leu Phe Ser Glu Asp Gly Ser Phe Ile Gly Ala
1185                1190                1195                1200
Tyr Ala Gly Ser Lys Glu Lys Gly Ser Val Glu Ser Asn Gly Ser Ser
                1205                1210                1215    
Thr Ala Thr Phe Pro Leu Arg Ala
            1220                


<210> 5944
<211> 2852
<212> PRT
<213> Homo sapiens

<400> 5944
Met Ala Leu Gly Lys Val Leu Ala Met Ala Leu Val Leu Ala Leu Ala
 1               5                  10                  15      
Val Leu Gly Ser Leu Ser Pro Gly Ala Arg Ala Gly Asp Cys Lys Gly
            20                  25                  30          
Gln Arg Gln Val Leu Arg Glu Ala Pro Gly Phe Val Thr Asp Gly Ala
        35                  40                  45              
Gly Asn Tyr Ser Val Asn Gly Asn Cys Glu Trp Leu Ile Glu Ala Pro
    50                  55                  60                  
Ser Pro Gln His Arg Ile Leu Leu Asp Phe Leu Phe Leu Asp Thr Glu
65                  70                  75                  80  
Cys Thr Tyr Asp Tyr Leu Phe Val Tyr Asp Gly Asp Ser Pro Arg Gly
                85                  90                  95      
Pro Leu Leu Ala Ser Leu Ser Gly Ser Thr Arg Pro Pro Pro Ile Glu
            100                 105                 110         
Ala Ser Ser Gly Lys Met Leu Leu His Leu Phe Ser Asp Ala Asn Tyr
        115                 120                 125             
Asn Leu Leu Gly Phe Asn Ala Ser Phe Arg Phe Ser Leu Cys Pro Gly
    130                 135                 140                 
Gly Cys Gln Ser His Gly Gln Cys Gln Pro Pro Gly Val Cys Ala Cys
145                 150                 155                 160 
Glu Pro Gly Trp Gly Gly Pro Asp Cys Gly Leu Gln Glu Cys Ser Ala
                165                 170                 175     
Tyr Cys Gly Ser His Gly Thr Cys Ala Ser Pro Leu Gly Pro Cys Arg
            180                 185                 190         
Cys Glu Pro Gly Phe Leu Gly Arg Ala Cys Asp Leu His Leu Trp Glu
        195                 200                 205             
Asn Gln Gly Ala Gly Trp Trp His Asn Val Ser Ala Arg Asp Pro Ala
    210                 215                 220                 
Phe Ser Ala Arg Ile Gly Ala Ala Gly Ala Phe Leu Ser Pro Pro Gly
225                 230                 235                 240 
Leu Leu Ala Val Phe Gly Gly Gln Asp Leu Asn Asn Ala Leu Gly Asp
                245                 250                 255     
Leu Val Leu Tyr Asn Phe Ser Ala Asn Thr Trp Glu Ser Trp Asp Leu
            260                 265                 270         
Ser Pro Ala Pro Ala Ala Arg His Ser His Val Ala Val Ala Trp Ala
        275                 280                 285             
Gly Ser Leu Val Leu Met Gly Gly Glu Leu Ala Asp Gly Ser Leu Thr
    290                 295                 300                 
Asn Asp Val Trp Ala Phe Ser Pro Leu Gly Arg Gly His Trp Glu Leu
305                 310                 315                 320 
Leu Ala Pro Pro Ala Ser Ser Ser Ser Gly Pro Pro Gly Leu Ala Gly
                325                 330                 335     
His Ala Ala Ala Leu Val Asp Asp Val Trp Leu Tyr Val Ser Gly Gly
            340                 345                 350         
Arg Thr Pro His Asp Leu Phe Ser Ser Gly Leu Phe Arg Phe Arg Leu
        355                 360                 365             
Asp Ser Thr Ser Gly Gly Tyr Trp Glu Gln Val Ile Pro Ala Gly Gly
    370                 375                 380                 
Arg Pro Pro Ala Ala Thr Gly His Ser Met Val Phe His Ala Pro Ser
385                 390                 395                 400 
Arg Ala Leu Leu Val His Gly Gly His Arg Pro Ser Thr Ala Arg Phe
                405                 410                 415     
Ser Val Arg Val Asn Ser Thr Glu Leu Phe His Val Asp Arg His Val
            420                 425                 430         
Trp Thr Thr Leu Lys Gly Arg Asp Gly Leu Gln Gly Pro Arg Glu Arg
        435                 440                 445             
Ala Phe His Thr Ala Ser Val Leu Gly Asn Tyr Met Val Val Tyr Gly
    450                 455                 460                 
Gly Asn Val His Thr His Tyr Gln Glu Glu Lys Cys Tyr Glu Asp Gly
465                 470                 475                 480 
Ile Phe Phe Tyr His Leu Gly Cys His Gln Trp Val Ser Gly Ala Glu
                485                 490                 495     
Leu Ala Pro Pro Gly Thr Pro Glu Gly Arg Ala Ala Pro Pro Ser Gly
            500                 505                 510         
Arg Tyr Ser His Val Ala Ala Val Leu Gly Gly Ser Val Leu Leu Val
        515                 520                 525             
Ala Gly Gly Tyr Ser Gly Arg Pro Arg Gly Asp Leu Met Ala Tyr Lys
    530                 535                 540                 
Val Pro Pro Phe Val Phe Gln Ala Pro Ala Pro Asp Tyr His Leu Asp
545                 550                 555                 560 
Tyr Cys Ser Met Tyr Thr Asp His Ser Val Cys Ser Arg Asp Pro Glu
                565                 570                 575     
Cys Ser Trp Cys Gln Gly Ala Cys Gln Ala Ala Pro Pro Pro Gly Thr
            580                 585                 590         
Pro Leu Gly Ala Cys Pro Ala Ala Ser Cys Leu Gly Leu Gly Arg Leu
        595                 600                 605             
Leu Gly Asp Cys Gln Ala Cys Leu Ala Phe Ser Ser Pro Thr Ala Pro
    610                 615                 620                 
Pro Arg Gly Pro Gly Thr Leu Gly Trp Cys Val His Asn Glu Ser Cys
625                 630                 635                 640 
Leu Pro Arg Pro Glu Gln Ala Arg Cys Arg Gly Glu Gln Ile Ser Gly
                645                 650                 655     
Thr Val Gly Trp Trp Gly Pro Ala Pro Val Phe Val Thr Ser Leu Glu
            660                 665                 670         
Ala Cys Val Thr Gln Ser Phe Leu Pro Gly Leu His Leu Leu Thr Phe
        675                 680                 685             
Gln Gln Pro Pro Asn Thr Ser Gln Pro Asp Lys Val Ser Ile Val Arg
    690                 695                 700                 
Ser Thr Thr Ile Thr Leu Thr Pro Ser Ala Glu Thr Asp Val Ser Leu
705                 710                 715                 720 
Val Tyr Arg Gly Phe Ile Tyr Pro Met Leu Pro Gly Gly Pro Gly Gly
                725                 730                 735     
Pro Gly Ala Glu Asp Val Ala Val Trp Thr Arg Ala Gln Arg Leu His
            740                 745                 750         
Val Leu Ala Arg Met Ala Arg Gly Pro Asp Thr Glu Asn Met Glu Glu
        755                 760                 765             
Val Gly Arg Trp Val Ala His Gln Glu Lys Glu Thr Arg Arg Leu Gln
    770                 775                 780                 
Arg Pro Gly Ser Ala Arg Leu Phe Pro Leu Pro Gly Arg Asp His Lys
785                 790                 795                 800 
Tyr Ala Val Glu Ile Gln Gly Gln Leu Asn Gly Ser Ala Gly Pro Gly
                805                 810                 815     
His Ser Glu Leu Thr Leu Leu Trp Asp Arg Thr Gly Val Pro Gly Gly
            820                 825                 830         
Ser Glu Ile Ser Phe Phe Phe Leu Glu Pro Tyr Arg Ser Ser Ser Cys
        835                 840                 845             
Thr Ser Tyr Ser Ser Cys Leu Gly Cys Leu Ala Asp Gln Gly Cys Gly
    850                 855                 860                 
Trp Cys Leu Thr Ser Ala Thr Cys His Leu Arg Gln Gly Gly Ala His
865                 870                 875                 880 
Cys Gly Asp Asp Gly Ala Gly Gly Ser Leu Leu Val Leu Val Pro Thr
                885                 890                 895     
Leu Cys Pro Leu Cys Glu Glu His Arg Asp Cys His Ala Cys Thr Gln
            900                 905                 910         
Asp Pro Phe Cys Glu Trp His Gln Ser Thr Ser Arg Lys Gly Asp Ala
        915                 920                 925             
Ala Cys Ser Arg Arg Gly Arg Gly Arg Gly Ala Leu Lys Ser Pro Glu
    930                 935                 940                 
Glu Cys Pro Pro Leu Cys Ser Gln Arg Leu Thr Cys Glu Asp Cys Leu
945                 950                 955                 960 
Ala Asn Ser Ser Gln Cys Ala Trp Cys Gln Ser Thr His Thr Cys Phe
                965                 970                 975     
Leu Phe Ala Ala Tyr Leu Ala Arg Tyr Pro His Gly Gly Cys Arg Gly
            980                 985                 990         
Trp Asp Asp Ser Val His Ser Glu Pro Arg Cys Arg Ser Cys Asp Gly
        995                 1000                1005            
Phe Leu Thr Cys His Glu Cys Leu Gln Ser His Glu Cys Gly Trp Cys
    1010                1015                1020                
Gly Asn Glu Asp Asn Pro Thr Leu Gly Arg Cys Leu Gln Gly Asp Phe
1025                1030                1035                1040
Ser Gly Pro Leu Gly Gly Gly Asn Cys Ser Leu Trp Val Gly Glu Gly
                1045                1050                1055    
Leu Gly Leu Pro Val Ala Leu Pro Ala Arg Trp Ala Tyr Ala Arg Cys
            1060                1065                1070        
Pro Asp Val Asp Glu Cys Arg Leu Gly Leu Ala Arg Cys His Pro Arg
        1075                1080                1085            
Ala Thr Cys Leu Asn Thr Pro Leu Ser Tyr Glu Cys His Cys Gln Arg
    1090                1095                1100                
Gly Tyr Gln Gly Asp Gly Ile Ser His Cys Asn Arg Thr Cys Leu Glu
1105                1110                1115                1120
Asp Cys Gly His Gly Val Cys Ser Gly Pro Pro Asp Phe Thr Cys Val
                1125                1130                1135    
Cys Asp Leu Gly Trp Thr Ser Asp Leu Pro Pro Pro Thr Pro Ala Pro
            1140                1145                1150        
Gly Pro Pro Ala Pro Arg Cys Ser Arg Asp Cys Gly Cys Ser Phe His
        1155                1160                1165            
Ser His Cys Arg Lys Arg Gly Pro Gly Phe Cys Asp Glu Cys Gln Asp
    1170                1175                1180                
Trp Thr Trp Gly Glu His Cys Glu Arg Cys Arg Pro Gly Ser Phe Gly
1185                1190                1195                1200
Asn Ala Thr Gly Ser Arg Gly Cys Arg Pro Cys Gln Cys Asn Gly His
                1205                1210                1215    
Gly Asp Pro Arg Arg Gly His Cys Asp Asn Leu Ser Gly Leu Cys Phe
            1220                1225                1230        
Cys Gln Asp His Thr Glu Gly Ala His Cys Gln Leu Cys Ser Pro Gly
        1235                1240                1245            
Tyr Tyr Gly Asp Pro Arg Ala Gly Gly Ser Cys Phe Arg Glu Cys Gly
    1250                1255                1260                
Gly Arg Ala Leu Leu Thr Asn Val Ser Ser Val Ala Leu Gly Ser Arg
1265                1270                1275                1280
Arg Val Gly Gly Leu Leu Pro Pro Gly Gly Gly Ala Ala Arg Ala Gly
                1285                1290                1295    
Pro Gly Leu Ser Tyr Cys Val Trp Val Val Ser Ala Thr Glu Glu Leu
            1300                1305                1310        
Gln Pro Cys Ala Pro Gly Thr Leu Cys Pro Pro Leu Thr Leu Thr Phe
        1315                1320                1325            
Ser Pro Asp Ser Ser Thr Pro Cys Thr Leu Ser Tyr Val Leu Ala Phe
    1330                1335                1340                
Asp Gly Phe Pro Arg Phe Leu Asp Thr Gly Val Val Gln Ser Asp Arg
1345                1350                1355                1360
Ser Leu Ile Ala Ala Phe Cys Gly Gln Arg Arg Asp Arg Pro Leu Thr
                1365                1370                1375    
Val Gln Ala Leu Ser Gly Leu Leu Val Leu His Trp Glu Ala Asn Gly
            1380                1385                1390        
Ser Ser Ser Trp Gly Phe Asn Ala Ser Val Gly Ser Ala Arg Cys Gly
        1395                1400                1405            
Ser Gly Gly Pro Gly Ser Cys Pro Val Pro Gln Glu Cys Val Pro Gln
    1410                1415                1420                
Asp Gly Ala Ala Gly Ala Gly Leu Cys Arg Cys Pro Gln Gly Trp Ala
1425                1430                1435                1440
Gly Pro His Cys Arg Met Ala Leu Cys Pro Glu Asn Cys Asn Ala His
                1445                1450                1455    
Thr Gly Ala Gly Thr Cys Asn Gln Ser Leu Gly Val Cys Ile Cys Ala
            1460                1465                1470        
Glu Gly Phe Gly Gly Pro Asp Cys Ala Thr Lys Leu Asp Gly Gly Gln
        1475                1480                1485            
Leu Val Trp Glu Thr Leu Met Asp Ser Arg Leu Ser Ala Asp Thr Ala
    1490                1495                1500                
Ser Arg Phe Leu His Arg Leu Gly His Thr Met Val Asp Gly Pro Asp
1505                1510                1515                1520
Ala Thr Leu Trp Met Phe Gly Gly Leu Gly Leu Pro Gln Gly Leu Leu
                1525                1530                1535    
Gly Asn Leu Tyr Arg Tyr Ser Val Ser Glu Arg Arg Trp Thr Gln Met
            1540                1545                1550        
Leu Ala Gly Ala Glu Asp Gly Gly Pro Gly Pro Ser Pro Arg Ser Phe
        1555                1560                1565            
His Ala Ala Ala Tyr Val Pro Ala Gly Arg Gly Ala Met Tyr Leu Leu
    1570                1575                1580                
Gly Gly Leu Thr Ala Gly Gly Val Thr Arg Asp Phe Trp Val Leu Asn
1585                1590                1595                1600
Leu Thr Thr Leu Gln Trp Arg Gln Glu Lys Ala Pro Gln Thr Val Glu
                1605                1610                1615    
Leu Pro Ala Val Ala Gly His Thr Leu Thr Ala Arg Arg Gly Leu Ser
            1620                1625                1630        
Leu Leu Leu Val Gly Gly Tyr Ser Pro Glu Asn Gly Phe Asn Gln Gln
        1635                1640                1645            
Leu Leu Glu Tyr Gln Leu Ala Thr Gly Thr Trp Val Ser Gly Ala Gln
    1650                1655                1660                
Ser Gly Thr Pro Pro Thr Gly Leu Tyr Gly His Ser Ala Val Tyr His
1665                1670                1675                1680
Glu Ala Thr Asp Ser Leu Tyr Val Phe Gly Gly Phe Arg Phe His Val
                1685                1690                1695    
Glu Leu Ala Ala Pro Ser Pro Glu Leu Tyr Ser Leu His Cys Pro Asp
            1700                1705                1710        
Arg Thr Trp Ser Leu Leu Ala Pro Ser Gln Gly Ala Lys Arg Asp Arg
        1715                1720                1725            
Met Arg Asn Val Arg Gly Ser Ser Arg Gly Leu Gly Gln Val Pro Gly
    1730                1735                1740                
Glu Gln Pro Gly Ser Trp Gly Phe Arg Glu Val Arg Lys Lys Met Ala
1745                1750                1755                1760
Leu Trp Ala Ala Leu Ala Gly Thr Gly Gly Phe Leu Glu Glu Ile Ser
                1765                1770                1775    
Pro His Leu Lys Glu Pro Arg Pro Arg Leu Phe His Ala Ser Ala Leu
            1780                1785                1790        
Leu Gly Asp Thr Met Val Val Leu Gly Gly Arg Ser Asp Pro Asp Glu
        1795                1800                1805            
Phe Ser Ser Asp Val Leu Leu Tyr Gln Val Asn Cys Asn Ala Trp Leu
    1810                1815                1820                
Leu Pro Asp Leu Thr Arg Ser Ala Ser Val Gly Pro Pro Met Glu Glu
1825                1830                1835                1840
Ser Val Ala His Ala Val Ala Ala Val Gly Ser Arg Leu Tyr Ile Ser
                1845                1850                1855    
Gly Gly Phe Gly Gly Val Ala Leu Gly Arg Leu Leu Ala Leu Thr Leu
            1860                1865                1870        
Pro Pro Asp Pro Cys Arg Leu Leu Ser Ser Pro Glu Ala Cys Asn Gln
        1875                1880                1885            
Ser Gly Ala Cys Thr Trp Cys His Gly Ala Cys Leu Ser Gly Asp Gln
    1890                1895                1900                
Ala His Arg Leu Gly Cys Gly Gly Ser Pro Cys Ser Pro Met Pro Arg
1905                1910                1915                1920
Ser Pro Glu Glu Cys Arg Arg Leu Arg Thr Cys Ser Glu Cys Leu Ala
                1925                1930                1935    
Arg His Pro Arg Thr Leu Gln Pro Gly Asp Gly Glu Ala Ser Thr Pro
            1940                1945                1950        
Arg Cys Lys Trp Cys Thr Asn Cys Pro Glu Gly Ala Cys Ile Gly Arg
        1955                1960                1965            
Asn Gly Ser Cys Thr Ser Glu Asn Asp Cys Arg Ile Asn Gln Arg Glu
    1970                1975                1980                
Val Phe Trp Ala Gly Asn Cys Ser Glu Ala Ala Cys Gly Ala Ala Asp
1985                1990                1995                2000
Cys Glu Gln Cys Thr Arg Glu Gly Lys Cys Met Trp Thr Arg Gln Phe
                2005                2010                2015    
Lys Arg Thr Gly Glu Thr Arg Arg Ile Leu Ser Val Gln Pro Thr Tyr
            2020                2025                2030        
Asp Trp Thr Cys Phe Ser His Ser Leu Leu Asn Val Ser Pro Met Pro
        2035                2040                2045            
Val Glu Ser Ser Pro Pro Leu Pro Cys Pro Thr Pro Cys His Leu Leu
    2050                2055                2060                
Pro Asn Cys Thr Ser Cys Leu Asp Ser Lys Gly Ala Asp Gly Gly Trp
2065                2070                2075                2080
Gln His Cys Val Trp Ser Ser Ser Leu Gln Gln Cys Leu Ser Pro Ser
                2085                2090                2095    
Tyr Leu Pro Leu Arg Cys Met Ala Gly Gly Cys Gly Arg Leu Leu Arg
            2100                2105                2110        
Gly Pro Glu Ser Cys Ser Leu Gly Cys Ala Gln Ala Thr Gln Cys Ala
        2115                2120                2125            
Leu Cys Leu Arg Arg Pro His Cys Gly Trp Cys Ala Trp Gly Gly Gln
    2130                2135                2140                
Asp Gly Gly Gly Arg Cys Met Glu Gly Gly Leu Ser Gly Pro Arg Asp
2145                2150                2155                2160
Gly Leu Thr Cys Gly Arg Pro Gly Ala Ser Trp Ala Phe Leu Ser Cys
                2165                2170                2175    
Pro Pro Glu Asp Glu Cys Ala Asn Gly His His Asp Cys Asn Glu Thr
            2180                2185                2190        
Gln Asn Cys His Asp Gln Pro His Gly Tyr Glu Cys Ser Cys Lys Thr
        2195                2200                2205            
Gly Tyr Thr Met Asp Asn Met Thr Gly Leu Cys Arg Pro Val Cys Ala
    2210                2215                2220                
Gln Gly Cys Val Asn Gly Ser Cys Val Glu Pro Asp His Cys Arg Cys
2225                2230                2235                2240
His Phe Gly Phe Val Gly Arg Asn Cys Ser Thr Glu Cys Arg Cys Asn
                2245                2250                2255    
Arg His Ser Glu Cys Ala Gly Val Gly Ala Arg Asp His Cys Leu Leu
            2260                2265                2270        
Cys Arg Asn His Thr Lys Gly Ser His Cys Glu Gln Cys Leu Pro Leu
        2275                2280                2285            
Phe Val Gly Ser Ala Val Gly Gly Gly Thr Cys Arg Pro Cys His Ala
    2290                2295                2300                
Phe Cys Arg Gly Asn Ser His Ile Cys Ile Ser Arg Lys Glu Leu Gln
2305                2310                2315                2320
Met Ser Lys Gly Glu Pro Lys Lys Tyr Ser Leu Asp Pro Glu Glu Ile
                2325                2330                2335    
Glu Asn Trp Val Thr Glu Gly Pro Ser Glu Asp Glu Ala Val Cys Val
            2340                2345                2350        
Asn Cys Gln Asn Asn Ser Tyr Gly Glu Lys Cys Glu Ser Cys Leu Gln
        2355                2360                2365            
Gly Tyr Phe Leu Leu Asp Gly Lys Cys Thr Lys Cys Gln Cys Asn Gly
    2370                2375                2380                
His Ala Asp Thr Cys Asn Glu Gln Asp Gly Thr Gly Cys Pro Cys Gln
2385                2390                2395                2400
Asn Asn Thr Glu Thr Gly Thr Cys Gln Gly Ser Ser Pro Ser Asp Arg
                2405                2410                2415    
Arg Asp Cys Tyr Lys Tyr Gln Val Arg Leu Gln Lys Leu Val Cys Ala
            2420                2425                2430        
Lys Cys Arg Glu Ser Phe His Gly Ser Pro Leu Gly Gly Gln Gln Cys
        2435                2440                2445            
Tyr Arg Leu Ile Ser Val Glu Gln Glu Cys Cys Leu Asp Pro Thr Ser
    2450                2455                2460                
Gln Thr Asn Cys Phe His Glu Pro Lys Arg Arg Ala Leu Gly Pro Gly
2465                2470                2475                2480
Arg Thr Val Leu Phe Gly Val Gln Pro Lys Phe Thr Asn Val Asp Ile
                2485                2490                2495    
Arg Leu Thr Leu Asp Val Thr Phe Gly Ala Val Asp Leu Tyr Val Ser
            2500                2505                2510        
Thr Ser Tyr Asp Thr Phe Val Val Arg Val Ala Pro Asp Thr Gly Val
        2515                2520                2525            
His Thr Val His Ile Gln Pro Pro Pro Ala Pro Pro Pro Pro Pro Pro
    2530                2535                2540                
Pro Ala Asp Gly Gly Pro Arg Gly Ala Gly Asp Pro Gly Gly Ala Gly
2545                2550                2555                2560
Ala Ser Ser Gly Pro Gly Ala Pro Ala Glu Pro Arg Val Arg Glu Val
                2565                2570                2575    
Trp Pro Arg Gly Leu Ile Thr Tyr Val Thr Val Thr Glu Pro Ser Ala
            2580                2585                2590        
Val Leu Val Val Arg Gly Val Arg Asp Arg Leu Val Ile Thr Tyr Pro
        2595                2600                2605            
His Glu His His Ala Leu Lys Ser Ser Arg Phe Tyr Leu Leu Leu Leu
    2610                2615                2620                
Gly Val Gly Asp Pro Ser Gly Pro Gly Ala Asn Gly Ser Ala Asp Ser
2625                2630                2635                2640
Gln Gly Leu Leu Phe Phe Arg Gln Asp Gln Ala His Ile Asp Leu Phe
                2645                2650                2655    
Val Phe Phe Ser Val Phe Phe Ser Cys Phe Phe Leu Phe Leu Ser Leu
            2660                2665                2670        
Cys Val Leu Leu Trp Lys Ala Lys Gln Ala Leu Asp Gln Arg Gln Glu
        2675                2680                2685            
Gln Arg Arg His Leu Gln Glu Met Thr Lys Met Ala Ser Arg Pro Phe
    2690                2695                2700                
Ala Lys Val Thr Val Cys Phe Pro Pro Asp Pro Thr Ala Pro Ala Ser
2705                2710                2715                2720
Ala Trp Lys Pro Ala Gly Leu Pro Pro Pro Ala Phe Arg Arg Ser Glu
                2725                2730                2735    
Pro Phe Leu Ala Pro Leu Leu Leu Thr Gly Ala Gly Gly Pro Trp Gly
            2740                2745                2750        
Pro Met Gly Gly Gly Cys Cys Pro Pro Ala Ile Pro Ala Thr Thr Ala
        2755                2760                2765            
Gly Leu Arg Ala Gly Pro Ile Thr Leu Glu Pro Thr Glu Asp Gly Met
    2770                2775                2780                
Ala Gly Val Ala Thr Leu Leu Leu Gln Leu Pro Gly Gly Pro His Ala
2785                2790                2795                2800
Pro Asn Gly Ala Cys Leu Gly Ser Ala Leu Val Thr Leu Arg His Arg
                2805                2810                2815    
Leu His Glu Tyr Cys Gly Gly Gly Gly Gly Ala Gly Gly Ser Gly His
            2820                2825                2830        
Gly Thr Gly Ala Gly Arg Lys Gly Leu Leu Ser Gln Asp Asn Leu Thr
        2835                2840                2845            
Ser Met Ser Leu
    2850        


<210> 5945
<211> 743
<212> PRT
<213> Homo sapiens

<400> 5945
Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala
 1               5                  10                  15      
Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val
            20                  25                  30          
Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe
        35                  40                  45              
Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr
    50                  55                  60                  
Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser
65                  70                  75                  80  
Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe
                85                  90                  95      
Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg
            100                 105                 110         
Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg
        115                 120                 125             
Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp
    130                 135                 140                 
Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn
145                 150                 155                 160 
Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln
                165                 170                 175     
Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe
            180                 185                 190         
Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His
        195                 200                 205             
Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr
    210                 215                 220                 
Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro
225                 230                 235                 240 
Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val
                245                 250                 255     
Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn
            260                 265                 270         
Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe
        275                 280                 285             
Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly
    290                 295                 300                 
Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro
305                 310                 315                 320 
Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu
                325                 330                 335     
Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp
            340                 345                 350         
Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala
        355                 360                 365             
Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe
    370                 375                 380                 
Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln
385                 390                 395                 400 
Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu
                405                 410                 415     
Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu
            420                 425                 430         
Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile
        435                 440                 445             
Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg
    450                 455                 460                 
Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala
465                 470                 475                 480 
Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu
                485                 490                 495     
Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His
            500                 505                 510         
Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser
        515                 520                 525             
Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu
    530                 535                 540                 
Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu
545                 550                 555                 560 
Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr
                565                 570                 575     
Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu
            580                 585                 590         
Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu
        595                 600                 605             
Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln
    610                 615                 620                 
Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln
625                 630                 635                 640 
Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu
                645                 650                 655     
Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr
            660                 665                 670         
Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln
        675                 680                 685             
Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu
    690                 695                 700                 
Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg
705                 710                 715                 720 
Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro
                725                 730                 735     
Gly Trp Val Ala Gly Ser Trp
            740             


<210> 5946
<211> 2377
<212> PRT
<213> Homo sapiens

<400> 5946
Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala
 1               5                  10                  15      
Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser
            20                  25                  30          
Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr
        35                  40                  45              
Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro
    50                  55                  60                  
Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys
65                  70                  75                  80  
Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val
                85                  90                  95      
Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile
            100                 105                 110         
Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser
        115                 120                 125             
Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala
    130                 135                 140                 
Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile
145                 150                 155                 160 
Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu
                165                 170                 175     
Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr
            180                 185                 190         
Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr
        195                 200                 205             
Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys
    210                 215                 220                 
Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu
225                 230                 235                 240 
Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe
                245                 250                 255     
Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu
            260                 265                 270         
Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu
        275                 280                 285             
Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp
    290                 295                 300                 
Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly
305                 310                 315                 320 
Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly
                325                 330                 335     
Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu
            340                 345                 350         
Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu
        355                 360                 365             
Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu
    370                 375                 380                 
Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr
385                 390                 395                 400 
Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu
                405                 410                 415     
Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val
            420                 425                 430         
Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro
        435                 440                 445             
Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln
    450                 455                 460                 
Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe
465                 470                 475                 480 
His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala
                485                 490                 495     
Gln Gln Ala Cys Pro Gly Thr Gly Ala Val Ile Ala Ser Pro Glu Gln
            500                 505                 510         
Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp
        515                 520                 525             
Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro
    530                 535                 540                 
Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val
545                 550                 555                 560 
Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu
                565                 570                 575     
Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln
            580                 585                 590         
Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Ala Thr Thr Gly
        595                 600                 605             
Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly
    610                 615                 620                 
Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro
625                 630                 635                 640 
Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro
                645                 650                 655     
Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys
            660                 665                 670         
Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly
        675                 680                 685             
Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln Val
    690                 695                 700                 
Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala Val
705                 710                 715                 720 
Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro Glu
                725                 730                 735     
Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser Pro
            740                 745                 750         
Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Glu Thr Glu
        755                 760                 765             
Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser Glu
    770                 775                 780                 
Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser Pro
785                 790                 795                 800 
Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu Leu
                805                 810                 815     
Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser Glu
            820                 825                 830         
Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Glu Pro
        835                 840                 845             
Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro Asp
    850                 855                 860                 
Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu Asp
865                 870                 875                 880 
Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser Gly
                885                 890                 895     
Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Thr
            900                 905                 910         
Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro
        915                 920                 925             
Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu
    930                 935                 940                 
Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Glu
945                 950                 955                 960 
Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro
                965                 970                 975     
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser
            980                 985                 990         
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu
        995                 1000                1005            
Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
    1010                1015                1020                
Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
1025                1030                1035                1040
Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val
                1045                1050                1055    
Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser
            1060                1065                1070        
Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly
        1075                1080                1085            
Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp
    1090                1095                1100                
Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly
1105                1110                1115                1120
Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala
                1125                1130                1135    
Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu
            1140                1145                1150        
Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly
        1155                1160                1165            
Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu
    1170                1175                1180                
Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile
1185                1190                1195                1200
Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val
                1205                1210                1215    
Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala
            1220                1225                1230        
Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu
        1235                1240                1245            
Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu
    1250                1255                1260                
Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro
1265                1270                1275                1280
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Glu Ile Ser
                1285                1290                1295    
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Asp
            1300                1305                1310        
Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
        1315                1320                1325            
Gly Val Glu Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
    1330                1335                1340                
Ser Thr Ser Ala Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Gly Glu
1345                1350                1355                1360
Val Leu Glu Ile Ser Val Ser Gly Val Glu Asp Ile Ser Gly Leu Pro
                1365                1370                1375    
Ser Gly Glu Val Val Glu Thr Ser Ala Ser Gly Ile Glu Asp Val Ser
            1380                1385                1390        
Glu Leu Pro Ser Gly Glu Gly Leu Glu Thr Ser Ala Ser Gly Val Glu
        1395                1400                1405            
Asp Leu Ser Arg Leu Pro Ser Gly Glu Glu Val Leu Glu Ile Ser Ala
    1410                1415                1420                
Ser Gly Phe Gly Asp Leu Ser Gly Val Pro Ser Gly Gly Glu Gly Leu
1425                1430                1435                1440
Glu Thr Ser Ala Ser Glu Val Gly Thr Asp Leu Ser Gly Leu Pro Ser
                1445                1450                1455    
Gly Arg Glu Gly Leu Glu Thr Ser Ala Ser Gly Ala Glu Asp Leu Ser
            1460                1465                1470        
Gly Leu Pro Ser Gly Lys Glu Asp Leu Val Gly Ser Ala Ser Gly Asp
        1475                1480                1485            
Leu Asp Leu Gly Lys Leu Pro Ser Gly Thr Leu Gly Ser Gly Gln Ala
    1490                1495                1500                
Pro Glu Thr Ser Gly Leu Pro Ser Gly Phe Ser Gly Glu Tyr Ser Gly
1505                1510                1515                1520
Val Asp Leu Gly Ser Gly Pro Pro Ser Gly Leu Pro Asp Phe Ser Gly
                1525                1530                1535    
Leu Pro Ser Gly Phe Pro Thr Val Ser Leu Val Asp Ser Thr Leu Val
            1540                1545                1550        
Glu Val Val Thr Ala Ser Thr Ala Ser Glu Leu Glu Gly Arg Gly Thr
        1555                1560                1565            
Ile Gly Ile Ser Gly Ala Gly Glu Ile Ser Gly Leu Pro Ser Ser Glu
    1570                1575                1580                
Leu Asp Ile Ser Gly Arg Ala Ser Gly Leu Pro Ser Gly Thr Glu Leu
1585                1590                1595                1600
Ser Gly Gln Ala Ser Gly Ser Pro Asp Val Ser Gly Glu Ile Pro Gly
                1605                1610                1615    
Leu Phe Gly Val Ser Gly Gln Pro Ser Gly Phe Pro Asp Thr Ser Gly
            1620                1625                1630        
Glu Thr Ser Gly Val Thr Glu Leu Ser Gly Leu Ser Ser Gly Gln Pro
        1635                1640                1645            
Gly Val Ser Gly Glu Ala Ser Gly Val Leu Tyr Gly Thr Ser Gln Pro
    1650                1655                1660                
Phe Gly Ile Thr Asp Leu Ser Gly Glu Thr Ser Gly Val Pro Asp Leu
1665                1670                1675                1680
Ser Gly Gln Pro Ser Gly Leu Pro Gly Phe Ser Gly Ala Thr Ser Gly
                1685                1690                1695    
Val Pro Asp Leu Val Ser Gly Thr Thr Ser Gly Ser Gly Glu Ser Ser
            1700                1705                1710        
Gly Ile Thr Phe Val Asp Thr Ser Leu Val Glu Val Ala Pro Thr Thr
        1715                1720                1725            
Phe Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Leu Ser Gly Leu Pro
    1730                1735                1740                
Ser Gly Glu Ala Asp Leu Ser Gly Lys Ser Gly Met Val Asp Val Ser
1745                1750                1755                1760
Gly Gln Phe Ser Gly Thr Val Asp Ser Ser Gly Phe Thr Ser Gln Thr
                1765                1770                1775    
Pro Glu Phe Ser Gly Leu Pro Ser Gly Ile Ala Glu Val Ser Gly Glu
            1780                1785                1790        
Ser Ser Arg Ala Glu Ile Gly Ser Ser Leu Pro Ser Gly Ala Tyr Tyr
        1795                1800                1805            
Gly Ser Gly Thr Pro Ser Ser Phe Pro Thr Val Ser Leu Val Asp Arg
    1810                1815                1820                
Thr Leu Val Glu Ser Val Thr Gln Ala Pro Thr Ala Gln Glu Ala Gly
1825                1830                1835                1840
Glu Gly Pro Ser Gly Ile Leu Glu Leu Ser Gly Ala His Ser Gly Ala
                1845                1850                1855    
Pro Asp Met Ser Gly Glu His Ser Gly Phe Leu Asp Leu Ser Gly Leu
            1860                1865                1870        
Gln Ser Gly Leu Ile Glu Pro Ser Gly Glu Pro Pro Gly Thr Pro Tyr
        1875                1880                1885            
Phe Ser Gly Asp Phe Ala Ser Thr Thr Asn Val Ser Gly Glu Ser Ser
    1890                1895                1900                
Val Ala Met Gly Thr Ser Gly Glu Ala Ser Gly Leu Pro Glu Val Thr
1905                1910                1915                1920
Leu Ile Thr Ser Glu Phe Val Glu Gly Val Thr Glu Pro Thr Ile Ser
                1925                1930                1935    
Gln Glu Leu Gly Gln Arg Pro Pro Val Thr His Thr Pro Gln Leu Phe
            1940                1945                1950        
Glu Ser Ser Gly Lys Val Ser Thr Ala Gly Asp Ile Ser Gly Ala Thr
        1955                1960                1965            
Pro Val Leu Pro Gly Ser Gly Val Glu Val Ser Ser Val Pro Glu Ser
    1970                1975                1980                
Ser Ser Glu Thr Ser Ala Tyr Pro Glu Ala Gly Phe Gly Ala Ser Ala
1985                1990                1995                2000
Ala Pro Glu Ala Ser Arg Glu Asp Ser Gly Ser Pro Asp Leu Ser Glu
                2005                2010                2015    
Thr Thr Ser Ala Phe His Glu Ala Asn Leu Glu Arg Ser Ser Gly Leu
            2020                2025                2030        
Gly Val Ser Gly Ser Thr Leu Thr Phe Gln Glu Gly Glu Ala Ser Ala
        2035                2040                2045            
Ala Pro Glu Val Ser Gly Glu Ser Thr Thr Thr Ser Asp Val Gly Thr
    2050                2055                2060                
Glu Ala Pro Gly Leu Pro Ser Ala Thr Pro Thr Ala Ser Gly Asp Arg
2065                2070                2075                2080
Thr Glu Ile Ser Gly Asp Leu Ser Gly His Thr Ser Gln Leu Gly Val
                2085                2090                2095    
Val Ile Ser Thr Ser Ile Pro Glu Ser Glu Trp Thr Gln Gln Thr Gln
            2100                2105                2110        
Arg Pro Ala Glu Thr His Leu Glu Ile Glu Ser Ser Ser Leu Leu Tyr
        2115                2120                2125            
Ser Gly Glu Glu Thr His Thr Val Glu Thr Ala Thr Ser Pro Thr Asp
    2130                2135                2140                
Ala Ser Ile Pro Ala Ser Pro Glu Trp Lys Arg Glu Ser Glu Ser Thr
2145                2150                2155                2160
Ala Ala Asp Gln Glu Val Cys Glu Glu Gly Trp Asn Lys Tyr Gln Gly
                2165                2170                2175    
His Cys Tyr Arg His Phe Pro Asp Arg Glu Thr Trp Val Asp Ala Glu
            2180                2185                2190        
Arg Arg Cys Arg Glu Gln Gln Ser His Leu Ser Ser Ile Val Thr Pro
        2195                2200                2205            
Glu Glu Gln Glu Phe Val Asn Asn Asn Ala Gln Asp Tyr Gln Trp Ile
    2210                2215                2220                
Gly Leu Asn Asp Arg Thr Ile Glu Gly Asp Phe Arg Trp Ser Asp Gly
2225                2230                2235                2240
His Pro Met Gln Phe Glu Asn Trp Arg Pro Asn Gln Pro Asp Asn Phe
                2245                2250                2255    
Phe Ala Ala Gly Glu Asp Cys Val Val Met Ile Trp His Glu Lys Gly
            2260                2265                2270        
Glu Trp Asn Asp Val Pro Cys Asn Tyr His Leu Pro Phe Thr Cys Lys
        2275                2280                2285            
Lys Gly Thr Val Ala Cys Gly Glu Pro Pro Val Val Glu His Ala Arg
    2290                2295                2300                
Thr Phe Gly Gln Lys Lys Asp Arg Tyr Glu Ile Asn Ser Leu Val Arg
2305                2310                2315                2320
Tyr Gln Cys Thr Glu Gly Phe Val Gln Arg His Met Pro Thr Ile Arg
                2325                2330                2335    
Cys Gln Pro Ser Gly His Trp Glu Glu Pro Arg Ile Thr Cys Thr Asp
            2340                2345                2350        
Ala Thr Thr Tyr Lys Arg Arg Leu Gln Lys Arg Ser Ser Arg His Pro
        2355                2360                2365            
Arg Arg Ser Arg Pro Ser Thr Ala His
    2370                2375        


<210> 5947
<211> 2415
<212> PRT
<213> Homo sapiens

<400> 5947
Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala
 1               5                  10                  15      
Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser
            20                  25                  30          
Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr
        35                  40                  45              
Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro
    50                  55                  60                  
Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys
65                  70                  75                  80  
Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val
                85                  90                  95      
Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile
            100                 105                 110         
Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser
        115                 120                 125             
Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala
    130                 135                 140                 
Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile
145                 150                 155                 160 
Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu
                165                 170                 175     
Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr
            180                 185                 190         
Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr
        195                 200                 205             
Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys
    210                 215                 220                 
Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu
225                 230                 235                 240 
Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe
                245                 250                 255     
Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu
            260                 265                 270         
Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu
        275                 280                 285             
Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp
    290                 295                 300                 
Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly
305                 310                 315                 320 
Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly
                325                 330                 335     
Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu
            340                 345                 350         
Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu
        355                 360                 365             
Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu
    370                 375                 380                 
Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr
385                 390                 395                 400 
Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu
                405                 410                 415     
Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val
            420                 425                 430         
Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro
        435                 440                 445             
Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln
    450                 455                 460                 
Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe
465                 470                 475                 480 
His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala
                485                 490                 495     
Gln Gln Ala Cys Pro Gly Thr Gly Ala Val Ile Ala Ser Pro Glu Gln
            500                 505                 510         
Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp
        515                 520                 525             
Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro
    530                 535                 540                 
Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val
545                 550                 555                 560 
Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu
                565                 570                 575     
Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln
            580                 585                 590         
Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Ala Thr Thr Gly
        595                 600                 605             
Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly
    610                 615                 620                 
Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro
625                 630                 635                 640 
Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro
                645                 650                 655     
Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys
            660                 665                 670         
Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly
        675                 680                 685             
Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln Val
    690                 695                 700                 
Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala Val
705                 710                 715                 720 
Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro Glu
                725                 730                 735     
Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser Pro
            740                 745                 750         
Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Glu Thr Glu
        755                 760                 765             
Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser Glu
    770                 775                 780                 
Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser Pro
785                 790                 795                 800 
Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu Leu
                805                 810                 815     
Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser Glu
            820                 825                 830         
Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Glu Pro
        835                 840                 845             
Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro Asp
    850                 855                 860                 
Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu Asp
865                 870                 875                 880 
Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser Gly
                885                 890                 895     
Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Thr
            900                 905                 910         
Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro
        915                 920                 925             
Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu
    930                 935                 940                 
Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Glu
945                 950                 955                 960 
Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro
                965                 970                 975     
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser
            980                 985                 990         
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu
        995                 1000                1005            
Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
    1010                1015                1020                
Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
1025                1030                1035                1040
Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val
                1045                1050                1055    
Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser
            1060                1065                1070        
Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly
        1075                1080                1085            
Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp
    1090                1095                1100                
Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly
1105                1110                1115                1120
Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala
                1125                1130                1135    
Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu
            1140                1145                1150        
Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly
        1155                1160                1165            
Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu
    1170                1175                1180                
Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile
1185                1190                1195                1200
Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val
                1205                1210                1215    
Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala
            1220                1225                1230        
Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu
        1235                1240                1245            
Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu
    1250                1255                1260                
Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro
1265                1270                1275                1280
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Glu Ile Ser
                1285                1290                1295    
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Asp
            1300                1305                1310        
Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
        1315                1320                1325            
Gly Val Glu Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
    1330                1335                1340                
Ser Thr Ser Ala Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Gly Glu
1345                1350                1355                1360
Val Leu Glu Ile Ser Val Ser Gly Val Glu Asp Ile Ser Gly Leu Pro
                1365                1370                1375    
Ser Gly Glu Val Val Glu Thr Ser Ala Ser Gly Ile Glu Asp Val Ser
            1380                1385                1390        
Glu Leu Pro Ser Gly Glu Gly Leu Glu Thr Ser Ala Ser Gly Val Glu
        1395                1400                1405            
Asp Leu Ser Arg Leu Pro Ser Gly Glu Glu Val Leu Glu Ile Ser Ala
    1410                1415                1420                
Ser Gly Phe Gly Asp Leu Ser Gly Val Pro Ser Gly Gly Glu Gly Leu
1425                1430                1435                1440
Glu Thr Ser Ala Ser Glu Val Gly Thr Asp Leu Ser Gly Leu Pro Ser
                1445                1450                1455    
Gly Arg Glu Gly Leu Glu Thr Ser Ala Ser Gly Ala Glu Asp Leu Ser
            1460                1465                1470        
Gly Leu Pro Ser Gly Lys Glu Asp Leu Val Gly Ser Ala Ser Gly Asp
        1475                1480                1485            
Leu Asp Leu Gly Lys Leu Pro Ser Gly Thr Leu Gly Ser Gly Gln Ala
    1490                1495                1500                
Pro Glu Thr Ser Gly Leu Pro Ser Gly Phe Ser Gly Glu Tyr Ser Gly
1505                1510                1515                1520
Val Asp Leu Gly Ser Gly Pro Pro Ser Gly Leu Pro Asp Phe Ser Gly
                1525                1530                1535    
Leu Pro Ser Gly Phe Pro Thr Val Ser Leu Val Asp Ser Thr Leu Val
            1540                1545                1550        
Glu Val Val Thr Ala Ser Thr Ala Ser Glu Leu Glu Gly Arg Gly Thr
        1555                1560                1565            
Ile Gly Ile Ser Gly Ala Gly Glu Ile Ser Gly Leu Pro Ser Ser Glu
    1570                1575                1580                
Leu Asp Ile Ser Gly Arg Ala Ser Gly Leu Pro Ser Gly Thr Glu Leu
1585                1590                1595                1600
Ser Gly Gln Ala Ser Gly Ser Pro Asp Val Ser Gly Glu Ile Pro Gly
                1605                1610                1615    
Leu Phe Gly Val Ser Gly Gln Pro Ser Gly Phe Pro Asp Thr Ser Gly
            1620                1625                1630        
Glu Thr Ser Gly Val Thr Glu Leu Ser Gly Leu Ser Ser Gly Gln Pro
        1635                1640                1645            
Gly Val Ser Gly Glu Ala Ser Gly Val Leu Tyr Gly Thr Ser Gln Pro
    1650                1655                1660                
Phe Gly Ile Thr Asp Leu Ser Gly Glu Thr Ser Gly Val Pro Asp Leu
1665                1670                1675                1680
Ser Gly Gln Pro Ser Gly Leu Pro Gly Phe Ser Gly Ala Thr Ser Gly
                1685                1690                1695    
Val Pro Asp Leu Val Ser Gly Thr Thr Ser Gly Ser Gly Glu Ser Ser
            1700                1705                1710        
Gly Ile Thr Phe Val Asp Thr Ser Leu Val Glu Val Ala Pro Thr Thr
        1715                1720                1725            
Phe Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Leu Ser Gly Leu Pro
    1730                1735                1740                
Ser Gly Glu Ala Asp Leu Ser Gly Lys Ser Gly Met Val Asp Val Ser
1745                1750                1755                1760
Gly Gln Phe Ser Gly Thr Val Asp Ser Ser Gly Phe Thr Ser Gln Thr
                1765                1770                1775    
Pro Glu Phe Ser Gly Leu Pro Ser Gly Ile Ala Glu Val Ser Gly Glu
            1780                1785                1790        
Ser Ser Arg Ala Glu Ile Gly Ser Ser Leu Pro Ser Gly Ala Tyr Tyr
        1795                1800                1805            
Gly Ser Gly Thr Pro Ser Ser Phe Pro Thr Val Ser Leu Val Asp Arg
    1810                1815                1820                
Thr Leu Val Glu Ser Val Thr Gln Ala Pro Thr Ala Gln Glu Ala Gly
1825                1830                1835                1840
Glu Gly Pro Ser Gly Ile Leu Glu Leu Ser Gly Ala His Ser Gly Ala
                1845                1850                1855    
Pro Asp Met Ser Gly Glu His Ser Gly Phe Leu Asp Leu Ser Gly Leu
            1860                1865                1870        
Gln Ser Gly Leu Ile Glu Pro Ser Gly Glu Pro Pro Gly Thr Pro Tyr
        1875                1880                1885            
Phe Ser Gly Asp Phe Ala Ser Thr Thr Asn Val Ser Gly Glu Ser Ser
    1890                1895                1900                
Val Ala Met Gly Thr Ser Gly Glu Ala Ser Gly Leu Pro Glu Val Thr
1905                1910                1915                1920
Leu Ile Thr Ser Glu Phe Val Glu Gly Val Thr Glu Pro Thr Ile Ser
                1925                1930                1935    
Gln Glu Leu Gly Gln Arg Pro Pro Val Thr His Thr Pro Gln Leu Phe
            1940                1945                1950        
Glu Ser Ser Gly Lys Val Ser Thr Ala Gly Asp Val Ser Gly Ala Thr
        1955                1960                1965            
Pro Val Leu Pro Gly Ser Gly Val Glu Val Ser Ser Val Pro Glu Ser
    1970                1975                1980                
Ser Ser Glu Thr Ser Ala Tyr Pro Glu Ala Gly Phe Gly Ala Ser Ala
1985                1990                1995                2000
Ala Pro Glu Ala Ser Arg Glu Asp Ser Gly Ser Pro Asp Leu Ser Glu
                2005                2010                2015    
Thr Thr Ser Ala Phe His Glu Ala Asn Leu Glu Arg Ser Ser Gly Leu
            2020                2025                2030        
Gly Val Ser Gly Ser Thr Leu Thr Phe Gln Glu Gly Glu Ala Ser Ala
        2035                2040                2045            
Ala Pro Glu Val Ser Gly Glu Ser Thr Thr Thr Ser Asp Val Gly Thr
    2050                2055                2060                
Glu Ala Pro Gly Leu Ala Ser Ala Thr Pro Thr Ala Ser Gly Asp Arg
2065                2070                2075                2080
Thr Glu Ile Ser Gly Asp Leu Ser Gly His Thr Ser Gln Leu Gly Val
                2085                2090                2095    
Val Ile Ser Thr Ser Ile Pro Glu Ser Glu Trp Thr Gln Gln Thr Gln
            2100                2105                2110        
Arg Pro Ala Glu Thr His Leu Glu Ile Glu Ser Ser Ser Leu Leu Tyr
        2115                2120                2125            
Ser Gly Glu Glu Thr His Thr Val Glu Thr Ala Thr Ser Pro Thr Asp
    2130                2135                2140                
Ala Ser Ile Pro Ala Ser Pro Glu Trp Lys Arg Glu Ser Glu Ser Thr
2145                2150                2155                2160
Ala Ala Ala Pro Ala Arg Ser Cys Ala Glu Glu Pro Cys Gly Ala Gly
                2165                2170                2175    
Thr Cys Lys Glu Thr Glu Gly His Val Ile Cys Leu Cys Pro Pro Gly
            2180                2185                2190        
Tyr Thr Gly Glu His Cys Asn Ile Asp Gln Glu Val Cys Glu Glu Gly
        2195                2200                2205            
Trp Asn Lys Tyr Gln Gly His Cys Tyr Arg His Phe Pro Asp Arg Glu
    2210                2215                2220                
Thr Trp Val Asp Ala Glu Arg Arg Cys Arg Glu Gln Gln Ser His Leu
2225                2230                2235                2240
Ser Ser Ile Val Thr Pro Glu Glu Gln Glu Phe Val Asn Asn Asn Ala
                2245                2250                2255    
Gln Asp Tyr Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile Glu Gly Asp
            2260                2265                2270        
Phe Arg Trp Ser Asp Gly His Pro Met Gln Phe Glu Asn Trp Arg Pro
        2275                2280                2285            
Asn Gln Pro Asp Asn Phe Phe Ala Ala Gly Glu Asp Cys Val Val Met
    2290                2295                2300                
Ile Trp His Glu Lys Gly Glu Trp Asn Asp Val Pro Cys Asn Tyr His
2305                2310                2315                2320
Leu Pro Phe Thr Cys Lys Lys Gly Thr Val Ala Cys Gly Glu Pro Pro
                2325                2330                2335    
Val Val Glu His Ala Arg Thr Phe Gly Gln Lys Lys Asp Arg Tyr Glu
            2340                2345                2350        
Ile Asn Ser Leu Val Arg Tyr Gln Cys Thr Glu Gly Phe Val Gln Arg
        2355                2360                2365            
His Met Pro Thr Ile Arg Cys Gln Pro Ser Gly His Trp Glu Glu Pro
    2370                2375                2380                
Arg Ile Thr Cys Thr Asp Pro Thr Thr Tyr Lys Arg Arg Leu Gln Lys
2385                2390                2395                2400
Arg Ser Ser Arg His Pro Arg Arg Ser Arg Pro Ser Thr Ala His
                2405                2410                2415


<210> 5948
<211> 2415
<212> PRT
<213> Homo sapiens

<400> 5948
Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala
 1               5                  10                  15      
Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser
            20                  25                  30          
Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr
        35                  40                  45              
Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro
    50                  55                  60                  
Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys
65                  70                  75                  80  
Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val
                85                  90                  95      
Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile
            100                 105                 110         
Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser
        115                 120                 125             
Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala
    130                 135                 140                 
Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile
145                 150                 155                 160 
Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu
                165                 170                 175     
Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr
            180                 185                 190         
Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr
        195                 200                 205             
Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys
    210                 215                 220                 
Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu
225                 230                 235                 240 
Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe
                245                 250                 255     
Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu
            260                 265                 270         
Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu
        275                 280                 285             
Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp
    290                 295                 300                 
Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly
305                 310                 315                 320 
Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly
                325                 330                 335     
Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu
            340                 345                 350         
Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu
        355                 360                 365             
Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu
    370                 375                 380                 
Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr
385                 390                 395                 400 
Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu
                405                 410                 415     
Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val
            420                 425                 430         
Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro
        435                 440                 445             
Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln
    450                 455                 460                 
Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe
465                 470                 475                 480 
His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala
                485                 490                 495     
Gln Gln Ala Cys Pro Gly Thr Gly Ala Val Ile Ala Ser Pro Glu Gln
            500                 505                 510         
Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp
        515                 520                 525             
Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro
    530                 535                 540                 
Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val
545                 550                 555                 560 
Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu
                565                 570                 575     
Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln
            580                 585                 590         
Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Ala Thr Thr Gly
        595                 600                 605             
Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly
    610                 615                 620                 
Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro
625                 630                 635                 640 
Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro
                645                 650                 655     
Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys
            660                 665                 670         
Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly
        675                 680                 685             
Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln Val
    690                 695                 700                 
Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala Val
705                 710                 715                 720 
Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro Glu
                725                 730                 735     
Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser Pro
            740                 745                 750         
Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Glu Thr Glu
        755                 760                 765             
Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser Glu
    770                 775                 780                 
Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser Pro
785                 790                 795                 800 
Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu Leu
                805                 810                 815     
Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser Glu
            820                 825                 830         
Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Glu Pro
        835                 840                 845             
Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro Asp
    850                 855                 860                 
Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu Asp
865                 870                 875                 880 
Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser Gly
                885                 890                 895     
Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Thr
            900                 905                 910         
Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro
        915                 920                 925             
Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu
    930                 935                 940                 
Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Glu
945                 950                 955                 960 
Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro
                965                 970                 975     
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser
            980                 985                 990         
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu
        995                 1000                1005            
Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
    1010                1015                1020                
Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
1025                1030                1035                1040
Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val
                1045                1050                1055    
Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser
            1060                1065                1070        
Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly
        1075                1080                1085            
Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp
    1090                1095                1100                
Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly
1105                1110                1115                1120
Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala
                1125                1130                1135    
Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu
            1140                1145                1150        
Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly
        1155                1160                1165            
Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu
    1170                1175                1180                
Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile
1185                1190                1195                1200
Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val
                1205                1210                1215    
Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala
            1220                1225                1230        
Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu
        1235                1240                1245            
Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu
    1250                1255                1260                
Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro
1265                1270                1275                1280
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Glu Ile Ser
                1285                1290                1295    
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Asp
            1300                1305                1310        
Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
        1315                1320                1325            
Gly Val Glu Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
    1330                1335                1340                
Ser Thr Ser Ala Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Gly Glu
1345                1350                1355                1360
Val Leu Glu Ile Ser Val Ser Gly Val Glu Asp Ile Ser Gly Leu Pro
                1365                1370                1375    
Ser Gly Glu Val Val Glu Thr Ser Ala Ser Gly Ile Glu Asp Val Ser
            1380                1385                1390        
Glu Leu Pro Ser Gly Glu Gly Leu Glu Thr Ser Ala Ser Gly Val Glu
        1395                1400                1405            
Asp Leu Ser Arg Leu Pro Ser Gly Glu Glu Val Leu Glu Ile Ser Ala
    1410                1415                1420                
Ser Gly Phe Gly Asp Leu Ser Gly Val Pro Ser Gly Gly Glu Gly Leu
1425                1430                1435                1440
Glu Thr Ser Ala Ser Glu Val Gly Thr Asp Leu Ser Gly Leu Pro Ser
                1445                1450                1455    
Gly Arg Glu Gly Leu Glu Thr Ser Ala Ser Gly Ala Glu Asp Leu Ser
            1460                1465                1470        
Gly Leu Pro Ser Gly Lys Glu Asp Leu Val Gly Ser Ala Ser Gly Asp
        1475                1480                1485            
Leu Asp Leu Gly Lys Leu Pro Ser Gly Thr Leu Gly Ser Gly Gln Ala
    1490                1495                1500                
Pro Glu Thr Ser Gly Leu Pro Ser Gly Phe Ser Gly Glu Tyr Ser Gly
1505                1510                1515                1520
Val Asp Leu Gly Ser Gly Pro Pro Ser Gly Leu Pro Asp Phe Ser Gly
                1525                1530                1535    
Leu Pro Ser Gly Phe Pro Thr Val Ser Leu Val Asp Ser Thr Leu Val
            1540                1545                1550        
Glu Val Val Thr Ala Ser Thr Ala Ser Glu Leu Glu Gly Arg Gly Thr
        1555                1560                1565            
Ile Gly Ile Ser Gly Ala Gly Glu Ile Ser Gly Leu Pro Ser Ser Glu
    1570                1575                1580                
Leu Asp Ile Ser Gly Arg Ala Ser Gly Leu Pro Ser Gly Thr Glu Leu
1585                1590                1595                1600
Ser Gly Gln Ala Ser Gly Ser Pro Asp Val Ser Gly Glu Ile Pro Gly
                1605                1610                1615    
Leu Phe Gly Val Ser Gly Gln Pro Ser Gly Phe Pro Asp Thr Ser Gly
            1620                1625                1630        
Glu Thr Ser Gly Val Thr Glu Leu Ser Gly Leu Ser Ser Gly Gln Pro
        1635                1640                1645            
Gly Val Ser Gly Glu Ala Ser Gly Val Leu Tyr Gly Thr Ser Gln Pro
    1650                1655                1660                
Phe Gly Ile Thr Asp Leu Ser Gly Glu Thr Ser Gly Val Pro Asp Leu
1665                1670                1675                1680
Ser Gly Gln Pro Ser Gly Leu Pro Gly Phe Ser Gly Ala Thr Ser Gly
                1685                1690                1695    
Val Pro Asp Leu Val Ser Gly Thr Thr Ser Gly Ser Gly Glu Ser Ser
            1700                1705                1710        
Gly Ile Thr Phe Val Asp Thr Ser Leu Val Glu Val Ala Pro Thr Thr
        1715                1720                1725            
Phe Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Leu Ser Gly Leu Pro
    1730                1735                1740                
Ser Gly Glu Ala Asp Leu Ser Gly Lys Ser Gly Met Val Asp Val Ser
1745                1750                1755                1760
Gly Gln Phe Ser Gly Thr Val Asp Ser Ser Gly Phe Thr Ser Gln Thr
                1765                1770                1775    
Pro Glu Phe Ser Gly Leu Pro Ser Gly Ile Ala Glu Val Ser Gly Glu
            1780                1785                1790        
Ser Ser Arg Ala Glu Ile Gly Ser Ser Leu Pro Ser Gly Ala Tyr Tyr
        1795                1800                1805            
Gly Ser Gly Thr Pro Ser Ser Phe Pro Thr Val Ser Leu Val Asp Arg
    1810                1815                1820                
Thr Leu Val Glu Ser Val Thr Gln Ala Pro Thr Ala Gln Glu Ala Gly
1825                1830                1835                1840
Glu Gly Pro Ser Gly Ile Leu Glu Leu Ser Gly Ala His Ser Gly Ala
                1845                1850                1855    
Pro Asp Met Ser Gly Glu His Ser Gly Phe Leu Asp Leu Ser Gly Leu
            1860                1865                1870        
Gln Ser Gly Leu Ile Glu Pro Ser Gly Glu Pro Pro Gly Thr Pro Tyr
        1875                1880                1885            
Phe Ser Gly Asp Phe Ala Ser Thr Thr Asn Val Ser Gly Glu Ser Ser
    1890                1895                1900                
Val Ala Met Gly Thr Ser Gly Glu Ala Ser Gly Leu Pro Glu Val Thr
1905                1910                1915                1920
Leu Ile Thr Ser Glu Phe Val Glu Gly Val Thr Glu Pro Thr Ile Ser
                1925                1930                1935    
Gln Glu Leu Gly Gln Arg Pro Pro Val Thr His Thr Pro Gln Leu Phe
            1940                1945                1950        
Glu Ser Ser Gly Lys Val Ser Thr Ala Gly Asp Ile Ser Gly Ala Thr
        1955                1960                1965            
Pro Val Leu Pro Gly Ser Gly Val Glu Val Ser Ser Val Pro Glu Ser
    1970                1975                1980                
Ser Ser Glu Thr Ser Ala Tyr Pro Glu Ala Gly Phe Gly Ala Ser Ala
1985                1990                1995                2000
Ala Pro Glu Ala Ser Arg Glu Asp Ser Gly Ser Pro Asp Leu Ser Glu
                2005                2010                2015    
Thr Thr Ser Ala Phe His Glu Ala Asn Leu Glu Arg Ser Ser Gly Leu
            2020                2025                2030        
Gly Val Ser Gly Ser Thr Leu Thr Phe Gln Glu Gly Glu Ala Ser Ala
        2035                2040                2045            
Ala Pro Glu Val Ser Gly Glu Ser Thr Thr Thr Ser Asp Val Gly Thr
    2050                2055                2060                
Glu Ala Pro Gly Leu Pro Ser Ala Thr Pro Thr Ala Ser Gly Asp Arg
2065                2070                2075                2080
Thr Glu Ile Ser Gly Asp Leu Ser Gly His Thr Ser Gln Leu Gly Val
                2085                2090                2095    
Val Ile Ser Thr Ser Ile Pro Glu Ser Glu Trp Thr Gln Gln Thr Gln
            2100                2105                2110        
Arg Pro Ala Glu Thr His Leu Glu Ile Glu Ser Ser Ser Leu Leu Tyr
        2115                2120                2125            
Ser Gly Glu Glu Thr His Thr Val Glu Thr Ala Thr Ser Pro Thr Asp
    2130                2135                2140                
Ala Ser Ile Pro Ala Ser Pro Glu Trp Lys Arg Glu Ser Glu Ser Thr
2145                2150                2155                2160
Ala Ala Ala Pro Ala Arg Ser Cys Ala Glu Glu Pro Cys Gly Ala Gly
                2165                2170                2175    
Thr Cys Lys Glu Thr Glu Gly His Val Ile Cys Leu Cys Pro Pro Gly
            2180                2185                2190        
Tyr Thr Gly Glu His Cys Asn Ile Asp Gln Glu Val Cys Glu Glu Gly
        2195                2200                2205            
Trp Asn Lys Tyr Gln Gly His Cys Tyr Arg His Phe Pro Asp Arg Glu
    2210                2215                2220                
Thr Trp Val Asp Ala Glu Arg Arg Cys Arg Glu Gln Gln Ser His Leu
2225                2230                2235                2240
Ser Ser Ile Val Thr Pro Glu Glu Gln Glu Phe Val Asn Asn Asn Ala
                2245                2250                2255    
Gln Asp Tyr Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile Glu Gly Asp
            2260                2265                2270        
Phe Arg Trp Ser Asp Gly His Pro Met Gln Phe Glu Asn Trp Arg Pro
        2275                2280                2285            
Asn Gln Pro Asp Asn Phe Phe Ala Ala Gly Glu Asp Cys Val Val Met
    2290                2295                2300                
Ile Trp His Glu Lys Gly Glu Trp Asn Asp Val Pro Cys Asn Tyr His
2305                2310                2315                2320
Leu Pro Phe Thr Cys Lys Lys Gly Thr Val Ala Cys Gly Glu Pro Pro
                2325                2330                2335    
Val Val Glu His Ala Arg Thr Phe Gly Gln Lys Lys Asp Arg Tyr Glu
            2340                2345                2350        
Ile Asn Ser Leu Val Arg Tyr Gln Cys Thr Glu Gly Phe Val Gln Arg
        2355                2360                2365            
His Met Pro Thr Ile Arg Cys Gln Pro Ser Gly His Trp Glu Glu Pro
    2370                2375                2380                
Arg Ile Thr Cys Thr Asp Ala Thr Thr Tyr Lys Arg Arg Leu Gln Lys
2385                2390                2395                2400
Arg Ser Ser Arg His Pro Arg Arg Ser Arg Pro Ser Thr Ala His
                2405                2410                2415


<210> 5949
<211> 2316
<212> PRT
<213> Homo sapiens

<400> 5949
Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala
 1               5                  10                  15      
Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser
            20                  25                  30          
Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr
        35                  40                  45              
Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro
    50                  55                  60                  
Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys
65                  70                  75                  80  
Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val
                85                  90                  95      
Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile
            100                 105                 110         
Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser
        115                 120                 125             
Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala
    130                 135                 140                 
Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile
145                 150                 155                 160 
Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu
                165                 170                 175     
Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr
            180                 185                 190         
Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr
        195                 200                 205             
Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys
    210                 215                 220                 
Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu
225                 230                 235                 240 
Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe
                245                 250                 255     
Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu
            260                 265                 270         
Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu
        275                 280                 285             
Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp
    290                 295                 300                 
Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly
305                 310                 315                 320 
Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly
                325                 330                 335     
Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu
            340                 345                 350         
Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu
        355                 360                 365             
Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu
    370                 375                 380                 
Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr
385                 390                 395                 400 
Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu
                405                 410                 415     
Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val
            420                 425                 430         
Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro
        435                 440                 445             
Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln
    450                 455                 460                 
Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe
465                 470                 475                 480 
His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala
                485                 490                 495     
Gln Gln Ala Cys Pro Gly Thr Gly Ala Val Ile Ala Ser Pro Glu Gln
            500                 505                 510         
Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp
        515                 520                 525             
Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro
    530                 535                 540                 
Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val
545                 550                 555                 560 
Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu
                565                 570                 575     
Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln
            580                 585                 590         
Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Ala Thr Thr Gly
        595                 600                 605             
Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly
    610                 615                 620                 
Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro
625                 630                 635                 640 
Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro
                645                 650                 655     
Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys
            660                 665                 670         
Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly
        675                 680                 685             
Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln Val
    690                 695                 700                 
Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala Val
705                 710                 715                 720 
Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro Glu
                725                 730                 735     
Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser Pro
            740                 745                 750         
Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Glu Thr Glu
        755                 760                 765             
Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser Glu
    770                 775                 780                 
Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser Pro
785                 790                 795                 800 
Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu Leu
                805                 810                 815     
Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser Glu
            820                 825                 830         
Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Glu Pro
        835                 840                 845             
Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro Asp
    850                 855                 860                 
Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu Asp
865                 870                 875                 880 
Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser Gly
                885                 890                 895     
Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Thr
            900                 905                 910         
Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro
        915                 920                 925             
Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu
    930                 935                 940                 
Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Glu
945                 950                 955                 960 
Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro
                965                 970                 975     
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser
            980                 985                 990         
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu
        995                 1000                1005            
Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
    1010                1015                1020                
Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
1025                1030                1035                1040
Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val
                1045                1050                1055    
Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser
            1060                1065                1070        
Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly
        1075                1080                1085            
Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp
    1090                1095                1100                
Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly
1105                1110                1115                1120
Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala
                1125                1130                1135    
Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu
            1140                1145                1150        
Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly
        1155                1160                1165            
Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu
    1170                1175                1180                
Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile
1185                1190                1195                1200
Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala Pro Gly Val
                1205                1210                1215    
Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ala Ala
            1220                1225                1230        
Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu
        1235                1240                1245            
Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu
    1250                1255                1260                
Val Leu Glu Thr Ala Ala Pro Gly Val Glu Asp Ile Ser Gly Leu Pro
1265                1270                1275                1280
Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Glu Ile Ser
                1285                1290                1295    
Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Asp
            1300                1305                1310        
Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro
        1315                1320                1325            
Gly Val Glu Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr
    1330                1335                1340                
Ser Thr Ser Ala Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Gly Glu
1345                1350                1355                1360
Val Leu Glu Ile Ser Val Ser Gly Val Glu Asp Ile Ser Gly Leu Pro
                1365                1370                1375    
Ser Gly Glu Val Val Glu Thr Ser Ala Ser Gly Ile Glu Asp Val Ser
            1380                1385                1390        
Glu Leu Pro Ser Gly Glu Gly Leu Glu Thr Ser Ala Ser Gly Val Glu
        1395                1400                1405            
Asp Leu Ser Arg Leu Pro Ser Gly Glu Glu Val Leu Glu Ile Ser Ala
    1410                1415                1420                
Ser Gly Phe Gly Asp Leu Ser Gly Val Pro Ser Gly Gly Glu Gly Leu
1425                1430                1435                1440
Glu Thr Ser Ala Ser Glu Val Gly Thr Asp Leu Ser Gly Leu Pro Ser
                1445                1450                1455    
Gly Arg Glu Gly Leu Glu Thr Ser Ala Ser Gly Ala Glu Asp Leu Ser
            1460                1465                1470        
Gly Leu Pro Ser Gly Lys Glu Asp Leu Val Gly Ser Ala Ser Gly Asp
        1475                1480                1485            
Leu Asp Leu Gly Lys Leu Pro Ser Gly Thr Leu Gly Ser Gly Gln Ala
    1490                1495                1500                
Pro Glu Thr Ser Gly Leu Pro Ser Gly Phe Ser Gly Glu Tyr Ser Gly
1505                1510                1515                1520
Val Asp Leu Gly Ser Gly Pro Pro Ser Gly Leu Pro Asp Phe Ser Gly
                1525                1530                1535    
Leu Pro Ser Gly Phe Pro Thr Val Ser Leu Val Asp Ser Thr Leu Val
            1540                1545                1550        
Glu Val Val Thr Ala Ser Thr Ala Ser Glu Leu Glu Gly Arg Gly Thr
        1555                1560                1565            
Ile Gly Ile Ser Gly Ala Gly Glu Ile Ser Gly Leu Pro Ser Ser Glu
    1570                1575                1580                
Leu Asp Ile Ser Gly Arg Ala Ser Gly Leu Pro Ser Gly Thr Glu Leu
1585                1590                1595                1600
Ser Gly Gln Ala Ser Gly Ser Pro Asp Val Ser Gly Glu Ile Pro Gly
                1605                1610                1615    
Leu Phe Gly Val Ser Gly Gln Pro Ser Gly Phe Pro Asp Thr Ser Gly
            1620                1625                1630        
Glu Thr Ser Gly Val Thr Glu Leu Ser Gly Leu Ser Ser Gly Gln Pro
        1635                1640                1645            
Gly Val Ser Gly Glu Ala Ser Gly Val Leu Tyr Gly Thr Ser Gln Pro
    1650                1655                1660                
Phe Gly Ile Thr Asp Leu Ser Gly Glu Thr Ser Gly Val Pro Asp Leu
1665                1670                1675                1680
Ser Gly Gln Pro Ser Gly Leu Pro Gly Phe Ser Gly Ala Thr Ser Gly
                1685                1690                1695    
Val Pro Asp Leu Val Ser Gly Thr Thr Ser Gly Ser Gly Glu Ser Ser
            1700                1705                1710        
Gly Ile Thr Phe Val Asp Thr Ser Leu Val Glu Val Ala Pro Thr Thr
        1715                1720                1725            
Phe Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Leu Ser Gly Leu Pro
    1730                1735                1740                
Ser Gly Glu Ala Asp Leu Ser Gly Lys Ser Gly Met Val Asp Val Ser
1745                1750                1755                1760
Gly Gln Phe Ser Gly Thr Val Asp Ser Ser Gly Phe Thr Ser Gln Thr
                1765                1770                1775    
Pro Glu Phe Ser Gly Leu Pro Ser Gly Ile Ala Glu Val Ser Gly Glu
            1780                1785                1790        
Ser Ser Arg Ala Glu Ile Gly Ser Ser Leu Pro Ser Gly Ala Tyr Tyr
        1795                1800                1805            
Gly Ser Gly Thr Pro Ser Ser Phe Pro Thr Val Ser Leu Val Asp Arg
    1810                1815                1820                
Thr Leu Val Glu Ser Val Thr Gln Ala Pro Thr Ala Gln Glu Ala Gly
1825                1830                1835                1840
Glu Gly Pro Ser Gly Ile Leu Glu Leu Ser Gly Ala His Ser Gly Ala
                1845                1850                1855    
Pro Asp Met Ser Gly Glu His Ser Gly Phe Leu Asp Leu Ser Gly Leu
            1860                1865                1870        
Gln Ser Gly Leu Ile Glu Pro Ser Gly Glu Pro Pro Gly Thr Pro Tyr
        1875                1880                1885            
Phe Ser Gly Asp Phe Ala Ser Thr Thr Asn Val Ser Gly Glu Ser Ser
    1890                1895                1900                
Val Ala Met Gly Thr Ser Gly Glu Ala Ser Gly Leu Pro Glu Val Thr
1905                1910                1915                1920
Leu Ile Thr Ser Glu Phe Val Glu Gly Val Thr Glu Pro Thr Ile Ser
                1925                1930                1935    
Gln Glu Leu Gly Gln Arg Pro Pro Val Thr His Thr Pro Gln Leu Phe
            1940                1945                1950        
Glu Ser Ser Gly Lys Val Ser Thr Ala Gly Asp Ile Ser Gly Ala Thr
        1955                1960                1965            
Pro Val Leu Pro Gly Ser Gly Val Glu Val Ser Ser Val Pro Glu Ser
    1970                1975                1980                
Ser Ser Glu Thr Ser Ala Tyr Pro Glu Ala Gly Phe Gly Ala Ser Ala
1985                1990                1995                2000
Ala Pro Glu Ala Ser Arg Glu Asp Ser Gly Ser Pro Asp Leu Ser Glu
                2005                2010                2015    
Thr Thr Ser Ala Phe His Glu Ala Asn Leu Glu Arg Ser Ser Gly Leu
            2020                2025                2030        
Gly Val Ser Gly Ser Thr Leu Thr Phe Gln Glu Gly Glu Ala Ser Ala
        2035                2040                2045            
Ala Pro Glu Val Ser Gly Glu Ser Thr Thr Thr Ser Asp Val Gly Thr
    2050                2055                2060                
Glu Ala Pro Gly Leu Pro Ser Ala Thr Pro Thr Ala Ser Gly Asp Arg
2065                2070                2075                2080
Thr Glu Ile Ser Gly Asp Leu Ser Gly His Thr Ser Gln Leu Gly Val
                2085                2090                2095    
Val Ile Ser Thr Ser Ile Pro Glu Ser Glu Trp Thr Gln Gln Thr Gln
            2100                2105                2110        
Arg Pro Ala Glu Thr His Leu Glu Ile Glu Ser Ser Ser Leu Leu Tyr
        2115                2120                2125            
Ser Gly Glu Glu Thr His Thr Val Glu Thr Ala Thr Ser Pro Thr Asp
    2130                2135                2140                
Ala Ser Ile Pro Ala Ser Pro Glu Trp Lys Arg Glu Ser Glu Ser Thr
2145                2150                2155                2160
Ala Ala Asp Gln Glu Val Cys Glu Glu Gly Trp Asn Lys Tyr Gln Gly
                2165                2170                2175    
His Cys Tyr Arg His Phe Pro Asp Arg Glu Thr Trp Val Asp Ala Glu
            2180                2185                2190        
Arg Arg Cys Arg Glu Gln Gln Ser His Leu Ser Ser Ile Val Thr Pro
        2195                2200                2205            
Glu Glu Gln Glu Phe Val Asn Asn Asn Ala Gln Asp Tyr Gln Trp Ile
    2210                2215                2220                
Gly Leu Asn Asp Arg Thr Ile Glu Gly Asp Phe Arg Trp Ser Asp Gly
2225                2230                2235                2240
His Pro Met Gln Phe Glu Asn Trp Arg Pro Asn Gln Pro Asp Asn Phe
                2245                2250                2255    
Phe Ala Ala Gly Glu Asp Cys Val Val Met Ile Trp His Glu Lys Gly
            2260                2265                2270        
Glu Trp Asn Asp Val Pro Cys Asn Tyr His Leu Pro Phe Thr Cys Lys
        2275                2280                2285            
Lys Gly Thr Ala Thr Thr Tyr Lys Arg Arg Leu Gln Lys Arg Ser Ser
    2290                2295                2300                
Arg His Pro Arg Arg Ser Arg Pro Ser Thr Ala His
2305                2310                2315    


<210> 5950
<211> 979
<212> PRT
<213> Homo sapiens

<400> 5950
Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu
 1               5                  10                  15      
Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu
            20                  25                  30          
Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu
        35                  40                  45              
His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys
    50                  55                  60                  
Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile
65                  70                  75                  80  
Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His
                85                  90                  95      
Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val
            100                 105                 110         
Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe
        115                 120                 125             
Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr
    130                 135                 140                 
Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu
145                 150                 155                 160 
Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn
                165                 170                 175     
Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp
            180                 185                 190         
Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn
        195                 200                 205             
Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu
    210                 215                 220                 
Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro
225                 230                 235                 240 
Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr
                245                 250                 255     
Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser
            260                 265                 270         
Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys
        275                 280                 285             
Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu
    290                 295                 300                 
Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser
305                 310                 315                 320 
Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro
                325                 330                 335     
Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr
            340                 345                 350         
Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile
        355                 360                 365             
Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys
    370                 375                 380                 
Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr
385                 390                 395                 400 
Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser
                405                 410                 415     
Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu
            420                 425                 430         
Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr
        435                 440                 445             
Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys
    450                 455                 460                 
Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser
465                 470                 475                 480 
Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile
                485                 490                 495     
Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val
            500                 505                 510         
Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn
        515                 520                 525             
Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser
    530                 535                 540                 
Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp
545                 550                 555                 560 
Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn
                565                 570                 575     
Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg
            580                 585                 590         
Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg
        595                 600                 605             
Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala
    610                 615                 620                 
Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser
625                 630                 635                 640 
Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe
                645                 650                 655     
Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His
            660                 665                 670         
Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys
        675                 680                 685             
Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu
    690                 695                 700                 
Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala
705                 710                 715                 720 
Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu
                725                 730                 735     
His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val
            740                 745                 750         
Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu
        755                 760                 765             
Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser
    770                 775                 780                 
Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser
785                 790                 795                 800 
Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr
                805                 810                 815     
Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu
            820                 825                 830         
Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser
        835                 840                 845             
Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala
    850                 855                 860                 
Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala
865                 870                 875                 880 
Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala
                885                 890                 895     
Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu
            900                 905                 910         
Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp
        915                 920                 925             
Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu
    930                 935                 940                 
Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro
945                 950                 955                 960 
Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu
                965                 970                 975     
His Tyr Cys
            


<210> 5951
<211> 352
<212> PRT
<213> Homo sapiens

<400> 5951
Met Ala Arg Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu
 1               5                  10                  15      
Ala Leu Gly Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val
            20                  25                  30          
Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val
        35                  40                  45              
Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln
    50                  55                  60                  
Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile
65                  70                  75                  80  
Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg
                85                  90                  95      
Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser
            100                 105                 110         
Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr
        115                 120                 125             
Phe Pro Thr Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala
    130                 135                 140                 
Lys Pro Thr Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys
145                 150                 155                 160 
Lys Gly Gln Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn
                165                 170                 175     
Gly Lys Pro Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu
            180                 185                 190         
Ala Glu Tyr Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile
        195                 200                 205             
Ser Arg Tyr Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu
    210                 215                 220                 
Ala Cys Ile Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr
225                 230                 235                 240 
Leu Asn Val Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly
                245                 250                 255     
Asn Trp Tyr Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp
            260                 265                 270         
Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser
        275                 280                 285             
Leu Pro Lys Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly
    290                 295                 300                 
Pro Ile Asn Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn
305                 310                 315                 320 
Pro Ile Gly Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Ala Phe
                325                 330                 335     
Cys Gln Leu Ile Tyr Pro Gly Lys Gly Arg Thr Arg Ala Arg Met Phe
            340                 345                 350         


<210> 5952
<211> 308
<212> PRT
<213> Homo sapiens

<400> 5952
Met Asn Ser Lys Arg Met Leu Leu Leu Val Leu Phe Ala Phe Ser Leu
 1               5                  10                  15      
Met Leu Val Glu Arg Tyr Phe Arg Asn His Gln Val Glu Glu Leu Arg
            20                  25                  30          
Leu Ser Asp Trp Phe His Pro Arg Lys Arg Pro Asp Val Ile Thr Lys
        35                  40                  45              
Thr Asp Trp Leu Ala Pro Val Leu Trp Glu Gly Thr Phe Asp Arg Arg
    50                  55                  60                  
Val Leu Glu Lys His Tyr Arg Arg Arg Asn Ile Thr Val Gly Leu Ala
65                  70                  75                  80  
Val Phe Ala Thr Gly Arg Phe Ala Glu Glu Tyr Leu Arg Pro Phe Leu
                85                  90                  95      
His Ser Ala Asn Lys His Phe Met Thr Gly Tyr Arg Val Ile Phe Tyr
            100                 105                 110         
Ile Met Val Asp Ala Phe Phe Lys Leu Pro Asp Ile Glu Pro Ser Pro
        115                 120                 125             
Leu Arg Thr Phe Lys Ala Phe Lys Val Gly Thr Glu Arg Trp Trp Leu
    130                 135                 140                 
Asp Gly Pro Leu Val His Val Lys Ser Leu Gly Glu His Ile Ala Ser
145                 150                 155                 160 
His Ile Gln Asp Glu Val Asp Phe Leu Phe Ser Met Ala Ala Asn Gln
                165                 170                 175     
Val Phe Gln Asn Glu Phe Gly Val Glu Thr Leu Gly Pro Leu Val Ala
            180                 185                 190         
Gln Leu His Ala Trp Trp Tyr Phe Arg Asn Thr Lys Asn Phe Pro Tyr
        195                 200                 205             
Glu Arg Arg Pro Thr Ser Ala Ala Cys Ile Pro Phe Gly Gln Gly Asp
    210                 215                 220                 
Phe Tyr Tyr Gly Asn Leu Met Val Gly Gly Thr Pro His Asn Ile Leu
225                 230                 235                 240 
Asp Phe Ile Lys Glu Tyr Leu Asn Gly Val Ile His Asp Ile Lys Asn
                245                 250                 255     
Gly Leu Asn Ser Thr Tyr Glu Lys His Leu Asn Lys Tyr Phe Tyr Leu
            260                 265                 270         
Asn Lys Pro Thr Lys Leu Leu Ser Pro Ala Tyr Ser Trp Asp Leu Ala
        275                 280                 285             
Phe Ser Pro Pro Pro Gln Ile Gln Tyr Val Lys Val Ala His Asp Ser
    290                 295                 300                 
Gln Arg Lys Leu
305             


<210> 5953
<211> 1404
<212> PRT
<213> Homo sapiens

<400> 5953
Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val
 1               5                  10                  15      
Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly
            20                  25                  30          
Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr
        35                  40                  45              
Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys
    50                  55                  60                  
Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg
65                  70                  75                  80  
Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys
                85                  90                  95      
Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser
            100                 105                 110         
Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr
        115                 120                 125             
Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys
    130                 135                 140                 
Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val
145                 150                 155                 160 
Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
                165                 170                 175     
Ser Thr Ile Trp Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg
            180                 185                 190         
Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr
        195                 200                 205             
Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser
    210                 215                 220                 
Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr
225                 230                 235                 240 
Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys
                245                 250                 255     
Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys
            260                 265                 270         
Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu
        275                 280                 285             
Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr
    290                 295                 300                 
Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp
305                 310                 315                 320 
Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu
                325                 330                 335     
Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro
            340                 345                 350         
Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro
        355                 360                 365             
Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
    370                 375                 380                 
Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
385                 390                 395                 400 
Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr
                405                 410                 415     
Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro
            420                 425                 430         
Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro
        435                 440                 445             
Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro
    450                 455                 460                 
Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys
465                 470                 475                 480 
Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys
                485                 490                 495     
Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys
            500                 505                 510         
Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys
        515                 520                 525             
Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser
    530                 535                 540                 
Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro
545                 550                 555                 560 
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro
                565                 570                 575     
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro
            580                 585                 590         
Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Ala Pro Lys Glu Pro
        595                 600                 605             
Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu
    610                 615                 620                 
Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro
625                 630                 635                 640 
Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro
                645                 650                 655     
Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala
            660                 665                 670         
Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro
        675                 680                 685             
Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr
    690                 695                 700                 
Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro
705                 710                 715                 720 
Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr
                725                 730                 735     
Thr Thr Lys Glu Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr
            740                 745                 750         
Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr
        755                 760                 765             
Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr
    770                 775                 780                 
Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys
785                 790                 795                 800 
Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp
                805                 810                 815     
Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys
            820                 825                 830         
Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu
        835                 840                 845             
Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys
    850                 855                 860                 
Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu
865                 870                 875                 880 
Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro
                885                 890                 895     
Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr
            900                 905                 910         
Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro
        915                 920                 925             
Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr
    930                 935                 940                 
Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val
945                 950                 955                 960 
Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu
                965                 970                 975     
Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile
            980                 985                 990         
Thr Thr Thr Glu Ile Met Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys
        995                 1000                1005            
Asp Arg Ala Thr Asn Ser Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro
    1010                1015                1020                
Thr Lys Ala Pro Lys Lys Pro Thr Ser Thr Lys Lys Pro Lys Thr Met
1025                1030                1035                1040
Pro Arg Val Arg Lys Pro Lys Thr Thr Pro Thr Pro Arg Lys Met Thr
                1045                1050                1055    
Ser Thr Met Pro Glu Leu Asn Pro Thr Ser Arg Ile Ala Glu Ala Met
            1060                1065                1070        
Leu Gln Thr Thr Thr Arg Pro Asn Gln Thr Pro Asn Ser Lys Leu Val
        1075                1080                1085            
Glu Val Asn Pro Lys Ser Glu Asp Ala Gly Gly Ala Glu Gly Glu Thr
    1090                1095                1100                
Pro His Met Leu Leu Arg Pro His Val Phe Met Pro Glu Val Thr Pro
1105                1110                1115                1120
Asp Met Asp Tyr Leu Pro Arg Val Pro Asn Gln Gly Ile Ile Ile Asn
                1125                1130                1135    
Pro Met Leu Ser Asp Glu Thr Asn Ile Cys Asn Gly Lys Pro Val Asp
            1140                1145                1150        
Gly Leu Thr Thr Leu Arg Asn Gly Thr Leu Val Ala Phe Arg Gly His
        1155                1160                1165            
Tyr Phe Trp Met Leu Ser Pro Phe Ser Pro Pro Ser Pro Ala Arg Arg
    1170                1175                1180                
Ile Thr Glu Val Trp Gly Ile Pro Ser Pro Ile Asp Thr Val Phe Thr
1185                1190                1195                1200
Arg Cys Asn Cys Glu Gly Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr
                1205                1210                1215    
Trp Arg Phe Thr Asn Asp Ile Lys Asp Ala Gly Tyr Pro Lys Pro Ile
            1220                1225                1230        
Phe Lys Gly Phe Gly Gly Leu Thr Gly Gln Ile Val Ala Ala Leu Ser
        1235                1240                1245            
Thr Ala Lys Tyr Lys Asn Trp Pro Glu Ser Val Tyr Phe Phe Lys Arg
    1250                1255                1260                
Gly Gly Ser Ile Gln Gln Tyr Ile Tyr Lys Gln Glu Pro Val Gln Lys
1265                1270                1275                1280
Cys Pro Gly Arg Arg Pro Ala Leu Asn Tyr Pro Val Tyr Gly Glu Met
                1285                1290                1295    
Thr Gln Val Arg Arg Arg Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln
            1300                1305                1310        
Thr His Thr Ile Arg Ile Gln Tyr Ser Pro Ala Arg Leu Ala Tyr Gln
        1315                1320                1325            
Asp Lys Gly Val Leu His Asn Glu Val Lys Val Ser Ile Leu Trp Arg
    1330                1335                1340                
Gly Leu Pro Asn Val Val Thr Ser Ala Ile Ser Leu Pro Asn Ile Arg
1345                1350                1355                1360
Lys Pro Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr
                1365                1370                1375    
Asn Ile Asp Val Pro Ser Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser
            1380                1385                1390        
Gly Gln Thr Leu Ser Lys Val Trp Tyr Asn Cys Pro
        1395                1400                


<210> 5954
<211> 708
<212> PRT
<213> Homo sapiens

<400> 5954
Met Arg Glu Arg Ile Trp Ala Pro Pro Leu Leu Leu Leu Leu Pro Leu
 1               5                  10                  15      
Leu Leu Pro Pro Pro Leu Trp Gly Gly Pro Pro Asp Ser Pro Arg Arg
            20                  25                  30          
Glu Leu Glu Leu Glu Pro Gly Pro Leu Gln Pro Phe Asp Leu Leu Tyr
        35                  40                  45              
Ala Ser Gly Ala Ala Ala Tyr Tyr Ser Gly Asp Tyr Glu Arg Ala Val
    50                  55                  60                  
Arg Asp Leu Glu Ala Ala Leu Arg Ser His Arg Arg Leu Arg Glu Ile
65                  70                  75                  80  
Arg Thr Arg Cys Ala Arg His Cys Ala Ala Arg His Pro Leu Pro Pro
                85                  90                  95      
Pro Pro Pro Gly Glu Gly Pro Gly Ala Glu Leu Pro Leu Phe Arg Ser
            100                 105                 110         
Leu Leu Gly Arg Ala Arg Cys Tyr Arg Ser Cys Glu Thr Gln Arg Leu
        115                 120                 125             
Gly Gly Pro Ala Ser Arg His Arg Val Ser Glu Asp Val Arg Ser Asp
    130                 135                 140                 
Phe Gln Arg Arg Val Pro Tyr Asn Tyr Leu Gln Arg Ala Tyr Ile Lys
145                 150                 155                 160 
Leu Asn Gln Leu Glu Lys Ala Val Glu Ala Ala His Thr Phe Phe Val
                165                 170                 175     
Ala Asn Pro Glu His Met Glu Met Gln Gln Asn Ile Glu Asn Tyr Arg
            180                 185                 190         
Ala Thr Ala Gly Val Glu Ala Leu Gln Leu Val Asp Arg Glu Ala Lys
        195                 200                 205             
Pro His Met Glu Ser Tyr Asn Ala Gly Val Lys His Tyr Glu Ala Asp
    210                 215                 220                 
Asp Phe Glu Met Ala Ile Arg His Phe Glu Gln Ala Leu Arg Glu Tyr
225                 230                 235                 240 
Phe Val Glu Asp Thr Glu Cys Arg Thr Leu Cys Glu Gly Pro Gln Arg
                245                 250                 255     
Phe Glu Glu Tyr Glu Tyr Leu Gly Tyr Lys Ala Gly Leu Tyr Glu Ala
            260                 265                 270         
Ile Ala Asp His Tyr Met Gln Val Leu Val Cys Gln His Glu Cys Val
        275                 280                 285             
Arg Glu Leu Ala Thr Arg Pro Gly Arg Leu Ser Pro Ile Glu Asn Phe
    290                 295                 300                 
Leu Pro Leu His Tyr Asp Tyr Leu Gln Phe Ala Tyr Tyr Arg Val Gly
305                 310                 315                 320 
Glu Tyr Val Lys Ala Leu Glu Cys Ala Lys Ala Tyr Leu Leu Cys His
                325                 330                 335     
Pro Asp Asp Glu Asp Val Leu Asp Asn Val Asp Tyr Tyr Glu Ser Leu
            340                 345                 350         
Leu Asp Asp Ser Ile Asp Pro Ala Ser Ile Glu Ala Arg Glu Asp Leu
        355                 360                 365             
Thr Met Phe Val Lys Arg His Lys Leu Glu Ser Glu Leu Ile Lys Ser
    370                 375                 380                 
Ala Ala Glu Gly Leu Gly Phe Ser Tyr Thr Glu Pro Asn Tyr Trp Ile
385                 390                 395                 400 
Arg Tyr Gly Gly Arg Gln Asp Glu Asn Arg Val Pro Ser Gly Val Asn
                405                 410                 415     
Val Glu Gly Ala Glu Val His Gly Phe Ser Met Gly Lys Lys Leu Ser
            420                 425                 430         
Pro Lys Ile Asp Arg Asp Leu Arg Glu Gly Gly Pro Leu Leu Tyr Glu
        435                 440                 445             
Asn Ile Thr Phe Val Tyr Asn Ser Glu Gln Leu Asn Gly Thr Gln Arg
    450                 455                 460                 
Val Leu Leu Asp Asn Val Leu Ser Glu Glu Gln Cys Arg Glu Leu His
465                 470                 475                 480 
Ser Val Ala Ser Gly Ile Met Leu Val Gly Asp Gly Tyr Arg Gly Lys
                485                 490                 495     
Thr Ser Pro His Thr Pro Asn Glu Lys Phe Glu Gly Ala Thr Val Leu
            500                 505                 510         
Lys Ala Leu Lys Ser Gly Tyr Glu Gly Arg Val Pro Leu Lys Ser Ala
        515                 520                 525             
Arg Leu Phe Tyr Asp Ile Ser Glu Lys Ala Arg Arg Ile Val Glu Ser
    530                 535                 540                 
Tyr Phe Met Leu Asn Ser Thr Leu Tyr Phe Ser Tyr Thr His Met Val
545                 550                 555                 560 
Cys Arg Thr Ala Leu Ser Gly Gln Gln Asp Arg Arg Asn Asp Leu Ser
                565                 570                 575     
His Pro Ile His Ala Asp Asn Cys Leu Leu Asp Pro Glu Ala Asn Glu
            580                 585                 590         
Cys Trp Lys Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Leu
        595                 600                 605             
Leu Tyr Met Asn Asp Asp Phe Glu Gly Gly Glu Phe Ile Phe Thr Glu
    610                 615                 620                 
Met Asp Ala Lys Thr Val Thr Ala Ser Ile Lys Pro Lys Cys Gly Arg
625                 630                 635                 640 
Met Ile Ser Phe Ser Ser Gly Gly Glu Asn Pro His Gly Val Lys Ala
                645                 650                 655     
Val Thr Lys Gly Lys Arg Cys Ala Val Ala Leu Trp Phe Thr Leu Asp
            660                 665                 670         
Pro Leu Tyr Arg Glu Leu Glu Arg Ile Gln Ala Asp Glu Val Ile Ala
        675                 680                 685             
Ile Leu Asp Gln Glu Gln Gln Gly Lys His Glu Leu Asn Ile Asn Pro
    690                 695                 700                 
Lys Asp Glu Leu
705             


<210> 5955
<211> 4289
<212> PRT
<213> Homo sapiens

<400> 5955
Met Met Pro Ala Gln Tyr Ala Leu Thr Ser Ser Leu Val Leu Leu Val
 1               5                  10                  15      
Leu Leu Ser Thr Ala Arg Ala Gly Pro Phe Ser Ser Arg Ser Asn Val
            20                  25                  30          
Thr Leu Pro Ala Pro Arg Pro Pro Pro Gln Pro Gly Gly His Thr Val
        35                  40                  45              
Gly Ala Gly Val Gly Ser Pro Ser Ser Gln Leu Tyr Glu His Thr Val
    50                  55                  60                  
Glu Gly Gly Glu Lys Gln Val Val Phe Thr His Arg Ile Asn Leu Pro
65                  70                  75                  80  
Pro Ser Thr Gly Cys Gly Cys Pro Pro Gly Thr Glu Pro Pro Val Leu
                85                  90                  95      
Ala Ser Glu Val Gln Ala Leu Arg Val Arg Leu Glu Ile Leu Glu Glu
            100                 105                 110         
Leu Val Lys Gly Leu Lys Glu Gln Cys Thr Gly Gly Cys Cys Pro Ala
        115                 120                 125             
Ser Ala Gln Ala Gly Thr Gly Gln Thr Asp Val Arg Thr Leu Cys Ser
    130                 135                 140                 
Leu His Gly Val Phe Asp Leu Ser Arg Cys Thr Cys Ser Cys Glu Pro
145                 150                 155                 160 
Gly Trp Gly Gly Pro Thr Cys Ser Asp Pro Thr Asp Ala Glu Ile Pro
                165                 170                 175     
Pro Ser Ser Pro Pro Ser Ala Ser Gly Ser Cys Pro Asp Asp Cys Asn
            180                 185                 190         
Asp Gln Gly Arg Cys Val Arg Gly Arg Cys Val Cys Phe Pro Gly Tyr
        195                 200                 205             
Thr Gly Pro Ser Cys Gly Trp Pro Ser Cys Pro Gly Asp Cys Gln Gly
    210                 215                 220                 
Arg Gly Arg Cys Val Gln Gly Val Cys Val Cys Arg Ala Gly Phe Ser
225                 230                 235                 240 
Gly Pro Asp Cys Ser Gln Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg
                245                 250                 255     
Gly Arg Cys Glu Gly Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly
            260                 265                 270         
Asp Asp Cys Gly Met Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly
        275                 280                 285             
Arg Cys Glu Asn Gly Arg Cys Val Cys Asn Pro Gly Tyr Thr Gly Glu
    290                 295                 300                 
Asp Cys Gly Val Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly Arg
305                 310                 315                 320 
Cys Lys Asp Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly Glu Asp
                325                 330                 335     
Cys Gly Thr Arg Ser Cys Pro Trp Asp Cys Gly Glu Gly Gly Arg Cys
            340                 345                 350         
Val Asp Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Glu Asp Cys
        355                 360                 365             
Ser Thr Arg Thr Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu
    370                 375                 380                 
Asp Gly Glu Cys Ile Cys Asp Thr Gly Tyr Ser Gly Asp Asp Cys Gly
385                 390                 395                 400 
Val Arg Ser Cys Pro Gly Asp Cys Asn Gln Arg Gly Arg Cys Glu Asp
                405                 410                 415     
Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Thr Asp Cys Gly Ser
            420                 425                 430         
Arg Ala Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu Asn Gly
        435                 440                 445             
Val Cys Val Cys Asn Ala Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg
    450                 455                 460                 
Ser Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Glu Ser Gly Arg
465                 470                 475                 480 
Cys Met Cys Trp Pro Gly Tyr Thr Gly Arg Asp Cys Gly Thr Arg Ala
                485                 490                 495     
Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Val Asp Gly Arg Cys
            500                 505                 510         
Val Cys Asn Pro Gly Phe Thr Gly Glu Asp Cys Gly Ser Arg Arg Cys
        515                 520                 525             
Pro Gly Asp Cys Arg Gly His Gly Leu Cys Glu Asp Gly Val Cys Val
    530                 535                 540                 
Cys Asp Ala Gly Tyr Ser Gly Glu Asp Cys Ser Thr Arg Ser Cys Pro
545                 550                 555                 560 
Gly Gly Cys Arg Gly Arg Gly Gln Cys Leu Asp Gly Arg Cys Val Cys
                565                 570                 575     
Glu Asp Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg Gln Cys Pro Asn
            580                 585                 590         
Asp Cys Ser Gln His Gly Val Cys Gln Asp Gly Val Cys Ile Cys Trp
        595                 600                 605             
Glu Gly Tyr Val Ser Glu Asp Cys Ser Ile Arg Thr Cys Pro Ser Asn
    610                 615                 620                 
Cys His Gly Arg Gly Arg Cys Glu Glu Gly Arg Cys Leu Cys Asp Pro
625                 630                 635                 640 
Gly Tyr Thr Gly Pro Thr Cys Ala Thr Arg Met Cys Pro Ala Asp Cys
                645                 650                 655     
Arg Gly Arg Gly Arg Cys Val Gln Gly Val Cys Leu Cys His Val Gly
            660                 665                 670         
Tyr Gly Gly Glu Asp Cys Gly Gln Glu Glu Pro Pro Ala Ser Ala Cys
        675                 680                 685             
Pro Gly Gly Cys Gly Pro Arg Glu Leu Cys Arg Ala Gly Gln Cys Val
    690                 695                 700                 
Cys Val Glu Gly Phe Arg Gly Pro Asp Cys Ala Ile Gln Thr Cys Pro
705                 710                 715                 720 
Gly Asp Cys Arg Gly Arg Gly Glu Cys His Asp Gly Ser Cys Val Cys
                725                 730                 735     
Lys Asp Gly Tyr Ala Gly Glu Asp Cys Gly Glu Ala Arg Val Pro Ser
            740                 745                 750         
Ser Ala Ser Ala Tyr Asp Gln Arg Gly Leu Ala Pro Gly Gln Glu Tyr
        755                 760                 765             
Gln Val Thr Val Arg Ala Leu Arg Gly Thr Ser Trp Gly Leu Pro Ala
    770                 775                 780                 
Ser Lys Thr Ile Thr Thr Met Ile Asp Gly Pro Gln Asp Leu Arg Val
785                 790                 795                 800 
Val Ala Val Thr Pro Thr Thr Leu Glu Leu Gly Trp Leu Arg Pro Gln
                805                 810                 815     
Ala Glu Val Asp Arg Phe Val Val Ser Tyr Val Ser Ala Gly Asn Gln
            820                 825                 830         
Arg Val Arg Leu Glu Val Pro Pro Glu Ala Asp Gly Thr Leu Leu Thr
        835                 840                 845             
Asp Leu Met Pro Gly Val Glu Tyr Val Val Thr Val Thr Ala Glu Arg
    850                 855                 860                 
Gly Arg Ala Val Ser Tyr Pro Ala Ser Val Arg Ala Asn Thr Glu Glu
865                 870                 875                 880 
Arg Glu Glu Glu Ser Pro Pro Arg Pro Ser Leu Ser Gln Pro Pro Arg
                885                 890                 895     
Arg Pro Trp Gly Asn Leu Thr Ala Glu Leu Ser Arg Phe Arg Gly Thr
            900                 905                 910         
Val Gln Asp Leu Glu Arg His Leu Arg Ala His Gly Tyr Pro Leu Arg
        915                 920                 925             
Ala Asn Gln Thr Tyr Thr Ser Val Ala Arg His Ile His Glu Tyr Leu
    930                 935                 940                 
Gln Arg Gln Val Leu Gly Ser Ser Ala Asp Gly Ala Leu Leu Val Ser
945                 950                 955                 960 
Leu Asp Gly Leu Arg Gly Gln Phe Glu Arg Val Val Leu Arg Trp Arg
                965                 970                 975     
Pro Gln Pro Pro Ala Glu Gly Pro Gly Gly Glu Leu Thr Val Pro Gly
            980                 985                 990         
Thr Thr Arg Thr Val Ser Leu Pro Asp Leu Arg Pro Gly Thr Thr Tyr
        995                 1000                1005            
His Val Glu Val His Gly Val Arg Ala Gly Gln Thr Ser Lys Ser Tyr
    1010                1015                1020                
Ala Phe Ile Thr Thr Thr Gly Pro Ser Thr Thr Gln Gly Ala Gln Ala
1025                1030                1035                1040
Pro Leu Leu Gln Gln Arg Pro Gln Glu Leu Gly Glu Leu Arg Val Leu
                1045                1050                1055    
Gly Arg Asp Glu Thr Gly Arg Leu Arg Val Val Trp Thr Ala Gln Pro
            1060                1065                1070        
Asp Thr Phe Ala Tyr Phe Gln Leu Arg Met Arg Val Pro Glu Gly Pro
        1075                1080                1085            
Gly Ala His Glu Glu Val Leu Pro Gly Asp Val Arg Gln Ala Leu Val
    1090                1095                1100                
Pro Pro Pro Pro Pro Gly Thr Pro Tyr Glu Leu Ser Leu His Gly Val
1105                1110                1115                1120
Pro Pro Gly Gly Lys Pro Ser Asp Pro Ile Ile Tyr Gln Gly Ile Met
                1125                1130                1135    
Asp Lys Asp Glu Glu Lys Pro Gly Lys Ser Ser Gly Pro Pro Arg Leu
            1140                1145                1150        
Gly Glu Leu Thr Val Thr Asp Arg Thr Ser Asp Ser Leu Leu Leu Arg
        1155                1160                1165            
Trp Thr Val Pro Glu Gly Glu Phe Asp Ser Phe Val Ile Gln Tyr Lys
    1170                1175                1180                
Asp Arg Asp Gly Gln Pro Gln Val Val Pro Val Glu Gly Pro Gln Arg
1185                1190                1195                1200
Ser Ala Val Ile Thr Ser Leu Asp Pro Gly Arg Lys Tyr Lys Phe Val
                1205                1210                1215    
Leu Tyr Gly Phe Val Gly Lys Lys Arg His Gly Pro Leu Val Ala Glu
            1220                1225                1230        
Ala Lys Ile Leu Pro Gln Ser Asp Pro Ser Pro Gly Thr Pro Pro His
        1235                1240                1245            
Leu Gly Asn Leu Trp Val Thr Asp Pro Thr Pro Asp Ser Leu His Leu
    1250                1255                1260                
Ser Trp Thr Val Pro Glu Gly Gln Phe Asp Thr Phe Met Val Gln Tyr
1265                1270                1275                1280
Arg Asp Arg Asp Gly Arg Pro Gln Val Val Pro Val Glu Gly Pro Glu
                1285                1290                1295    
Arg Ser Phe Val Val Ser Ser Leu Asp Pro Asp His Lys Tyr Arg Phe
            1300                1305                1310        
Thr Leu Phe Gly Ile Ala Asn Lys Lys Arg Tyr Gly Pro Leu Thr Ala
        1315                1320                1325            
Asp Gly Thr Thr Ala Pro Glu Arg Lys Glu Glu Pro Pro Arg Pro Glu
    1330                1335                1340                
Phe Leu Glu Gln Pro Leu Leu Gly Glu Leu Thr Val Thr Gly Val Thr
1345                1350                1355                1360
Pro Asp Ser Leu Arg Leu Ser Trp Thr Val Ala Gln Gly Pro Phe Asp
                1365                1370                1375    
Ser Phe Met Val Gln Tyr Lys Asp Ala Gln Gly Gln Pro Gln Ala Val
            1380                1385                1390        
Pro Val Ala Gly Asp Glu Asn Glu Val Thr Val Pro Gly Leu Asp Pro
        1395                1400                1405            
Asp Arg Lys Tyr Lys Met Asn Leu Tyr Gly Leu Arg Gly Arg Gln Arg
    1410                1415                1420                
Val Gly Pro Glu Ser Val Val Ala Lys Thr Ala Pro Gln Glu Asp Val
1425                1430                1435                1440
Asp Glu Thr Pro Ser Pro Thr Glu Leu Gly Thr Glu Ala Pro Glu Ser
                1445                1450                1455    
Pro Glu Glu Pro Leu Leu Gly Glu Leu Thr Val Thr Gly Ser Ser Pro
            1460                1465                1470        
Asp Ser Leu Ser Leu Phe Trp Thr Val Pro Gln Gly Ser Phe Asp Ser
        1475                1480                1485            
Phe Thr Val Gln Tyr Lys Asp Arg Asp Gly Arg Pro Arg Ala Val Arg
    1490                1495                1500                
Val Gly Gly Lys Glu Ser Glu Val Thr Val Gly Gly Leu Glu Pro Gly
1505                1510                1515                1520
His Lys Tyr Lys Met His Leu Tyr Gly Leu His Glu Gly Gln Arg Val
                1525                1530                1535    
Gly Pro Val Ser Ala Val Gly Val Thr Ala Pro Gln Gln Glu Glu Thr
            1540                1545                1550        
Pro Pro Ala Thr Glu Ser Pro Leu Glu Pro Arg Leu Gly Glu Leu Thr
        1555                1560                1565            
Val Thr Asp Val Thr Pro Asn Ser Val Gly Leu Ser Trp Thr Val Pro
    1570                1575                1580                
Glu Gly Gln Phe Asp Ser Phe Ile Val Gln Tyr Lys Asp Lys Asp Gly
1585                1590                1595                1600
Gln Pro Gln Val Val Pro Val Ala Ala Asp Gln Arg Glu Val Thr Val
                1605                1610                1615    
Tyr Asn Leu Glu Pro Glu Arg Lys Tyr Lys Met Asn Met Tyr Gly Leu
            1620                1625                1630        
His Asp Gly Gln Arg Met Gly Pro Leu Ser Val Val Ile Val Thr Ala
        1635                1640                1645            
Pro Ala Thr Glu Ala Ser Lys Pro Pro Leu Glu Pro Arg Leu Gly Glu
    1650                1655                1660                
Leu Thr Val Thr Asp Ile Thr Pro Asp Ser Val Gly Leu Ser Trp Thr
1665                1670                1675                1680
Val Pro Glu Gly Glu Phe Asp Ser Phe Val Val Gln Tyr Lys Asp Arg
                1685                1690                1695    
Asp Gly Gln Pro Gln Val Val Pro Val Ala Ala Asp Gln Arg Glu Val
            1700                1705                1710        
Thr Ile Pro Asp Leu Glu Pro Ser Arg Lys Tyr Lys Phe Leu Leu Phe
        1715                1720                1725            
Gly Ile Gln Asp Gly Lys Arg Arg Ser Pro Val Ser Val Glu Ala Lys
    1730                1735                1740                
Thr Val Ala Arg Gly Asp Ala Ser Pro Gly Ala Pro Pro Arg Leu Gly
1745                1750                1755                1760
Glu Leu Trp Val Thr Asp Pro Thr Pro Asp Ser Leu Arg Leu Ser Trp
                1765                1770                1775    
Thr Val Pro Glu Gly Gln Phe Asp Ser Phe Val Val Gln Phe Lys Asp
            1780                1785                1790        
Lys Asp Gly Pro Gln Val Val Pro Val Glu Gly His Glu Arg Ser Val
        1795                1800                1805            
Thr Val Thr Pro Leu Asp Ala Gly Arg Lys Tyr Arg Phe Leu Leu Tyr
    1810                1815                1820                
Gly Leu Leu Gly Lys Lys Arg His Gly Pro Leu Thr Ala Asp Gly Thr
1825                1830                1835                1840
Thr Glu Ala Arg Ser Ala Met Asp Asp Thr Gly Thr Lys Arg Pro Pro
                1845                1850                1855    
Lys Pro Arg Leu Gly Glu Glu Leu Gln Val Thr Thr Val Thr Gln Asn
            1860                1865                1870        
Ser Val Gly Leu Ser Trp Thr Val Pro Glu Gly Gln Phe Asp Ser Phe
        1875                1880                1885            
Val Val Gln Tyr Lys Asp Arg Asp Gly Gln Pro Gln Val Val Pro Val
    1890                1895                1900                
Glu Gly Ser Leu Arg Glu Val Ser Val Pro Gly Leu Asp Pro Ala His
1905                1910                1915                1920
Arg Tyr Lys Leu Leu Leu Tyr Gly Leu His His Gly Lys Arg Val Gly
                1925                1930                1935    
Pro Ile Ser Ala Val Ala Ile Thr Ala Gly Arg Glu Glu Thr Glu Thr
            1940                1945                1950        
Glu Thr Thr Ala Pro Thr Pro Pro Ala Pro Glu Pro His Leu Gly Glu
        1955                1960                1965            
Leu Thr Val Glu Glu Ala Thr Ser His Thr Leu His Leu Ser Trp Met
    1970                1975                1980                
Val Thr Glu Gly Glu Phe Asp Ser Phe Glu Ile Gln Tyr Thr Asp Arg
1985                1990                1995                2000
Asp Gly Gln Leu Gln Met Val Arg Ile Gly Gly Asp Arg Asn Asp Ile
                2005                2010                2015    
Thr Leu Ser Gly Leu Glu Ser Asp His Arg Tyr Leu Val Thr Leu Tyr
            2020                2025                2030        
Gly Phe Ser Asp Gly Lys His Val Gly Pro Val His Val Glu Ala Leu
        2035                2040                2045            
Thr Val Pro Glu Glu Glu Lys Pro Ser Glu Pro Pro Thr Ala Thr Pro
    2050                2055                2060                
Glu Pro Pro Ile Lys Pro Arg Leu Gly Glu Leu Thr Val Thr Asp Ala
2065                2070                2075                2080
Thr Pro Asp Ser Leu Ser Leu Ser Trp Thr Val Pro Glu Gly Gln Phe
                2085                2090                2095    
Asp His Phe Leu Val Gln Tyr Arg Asn Gly Asp Gly Gln Pro Lys Ala
            2100                2105                2110        
Val Arg Val Pro Gly His Glu Glu Gly Val Thr Ile Ser Gly Leu Glu
        2115                2120                2125            
Pro Asp His Lys Tyr Lys Met Asn Leu Tyr Gly Phe His Gly Gly Gln
    2130                2135                2140                
Arg Met Gly Pro Val Ser Val Val Gly Val Thr Glu Pro Ser Met Glu
2145                2150                2155                2160
Ala Pro Glu Pro Ala Glu Glu Pro Leu Leu Gly Glu Leu Thr Val Thr
                2165                2170                2175    
Gly Ser Ser Pro Asp Ser Leu Ser Leu Ser Trp Thr Val Pro Gln Gly
            2180                2185                2190        
Arg Phe Asp Ser Phe Thr Val Gln Tyr Lys Asp Arg Asp Gly Arg Pro
        2195                2200                2205            
Gln Val Val Arg Val Gly Gly Glu Glu Ser Glu Val Thr Val Gly Gly
    2210                2215                2220                
Leu Glu Pro Gly Arg Lys Tyr Lys Met His Leu Tyr Gly Leu His Glu
2225                2230                2235                2240
Gly Arg Arg Val Gly Pro Val Ser Ala Val Gly Val Thr Ala Pro Glu
                2245                2250                2255    
Glu Glu Ser Pro Asp Ala Pro Leu Ala Lys Leu Arg Leu Gly Gln Met
            2260                2265                2270        
Thr Val Arg Asp Ile Thr Ser Asp Ser Leu Ser Leu Ser Trp Thr Val
        2275                2280                2285            
Pro Glu Gly Gln Phe Asp His Phe Leu Val Gln Phe Lys Asn Gly Asp
    2290                2295                2300                
Gly Gln Pro Lys Ala Val Arg Val Pro Gly His Glu Asp Gly Val Thr
2305                2310                2315                2320
Ile Ser Gly Leu Glu Pro Asp His Lys Tyr Lys Met Asn Leu Tyr Gly
                2325                2330                2335    
Phe His Gly Gly Gln Arg Val Gly Pro Val Ser Ala Val Gly Leu Thr
            2340                2345                2350        
Ala Ser Thr Glu Pro Pro Thr Pro Glu Pro Pro Ile Lys Pro Arg Leu
        2355                2360                2365            
Glu Glu Leu Thr Val Thr Asp Ala Thr Pro Asp Ser Leu Ser Leu Ser
    2370                2375                2380                
Trp Thr Val Pro Glu Gly Gln Phe Asp His Phe Leu Val Gln Tyr Lys
2385                2390                2395                2400
Asn Gly Asp Gly Gln Pro Lys Ala Thr Arg Val Pro Gly His Glu Asp
                2405                2410                2415    
Arg Val Thr Ile Ser Gly Leu Glu Pro Asp Asn Lys Tyr Lys Met Asn
            2420                2425                2430        
Leu Tyr Gly Phe His Gly Gly Gln Arg Val Gly Pro Val Ser Ala Ile
        2435                2440                2445            
Gly Val Thr Glu Glu Glu Thr Pro Ser Pro Thr Glu Pro Ser Met Glu
    2450                2455                2460                
Ala Pro Glu Pro Pro Glu Glu Pro Leu Leu Gly Glu Leu Thr Val Thr
2465                2470                2475                2480
Gly Ser Ser Pro Asp Ser Leu Ser Leu Ser Trp Thr Val Pro Gln Gly
                2485                2490                2495    
Arg Phe Asp Ser Phe Thr Val Gln Tyr Lys Asp Arg Asp Gly Arg Pro
            2500                2505                2510        
Gln Val Val Arg Val Gly Gly Glu Glu Ser Glu Val Thr Val Gly Gly
        2515                2520                2525            
Leu Glu Pro Gly Arg Lys Tyr Lys Met His Leu Tyr Gly Leu His Glu
    2530                2535                2540                
Gly Arg Arg Val Gly Pro Val Ser Thr Val Gly Val Thr Ala Pro Gln
2545                2550                2555                2560
Glu Asp Val Asp Glu Thr Pro Ser Pro Thr Glu Pro Gly Thr Glu Ala
                2565                2570                2575    
Pro Glu Pro Pro Glu Glu Pro Leu Leu Gly Glu Leu Thr Val Thr Gly
            2580                2585                2590        
Ser Ser Pro Asp Ser Leu Ser Leu Ser Trp Thr Val Pro Gln Gly Arg
        2595                2600                2605            
Phe Asp Ser Phe Thr Val Gln Tyr Lys Asp Arg Asp Gly Arg Pro Gln
    2610                2615                2620                
Ala Val Arg Val Gly Gly Gln Glu Ser Lys Val Thr Val Arg Gly Leu
2625                2630                2635                2640
Glu Pro Gly Arg Lys Tyr Lys Met His Leu Tyr Gly Leu His Glu Gly
                2645                2650                2655    
Arg Arg Leu Gly Pro Val Ser Ala Val Gly Val Thr Glu Asp Glu Ala
            2660                2665                2670        
Glu Thr Thr Gln Ala Val Pro Thr Met Thr Pro Glu Pro Pro Ile Lys
        2675                2680                2685            
Pro Arg Leu Gly Glu Leu Thr Met Thr Asp Ala Thr Pro Asp Ser Leu
    2690                2695                2700                
Ser Leu Ser Trp Thr Val Pro Glu Gly Gln Phe Asp His Phe Leu Val
2705                2710                2715                2720
Gln Tyr Arg Asn Gly Asp Gly Gln Pro Lys Ala Val Arg Val Pro Gly
                2725                2730                2735    
His Glu Asp Gly Val Thr Ile Ser Gly Leu Glu Pro Asp His Lys Tyr
            2740                2745                2750        
Lys Met Asn Leu Tyr Gly Phe His Gly Gly Gln Arg Val Gly Pro Ile
        2755                2760                2765            
Ser Val Ile Gly Val Thr Glu Glu Glu Thr Pro Ser Pro Thr Glu Leu
    2770                2775                2780                
Ser Thr Glu Ala Arg Glu Pro Pro Glu Glu Pro Leu Leu Gly Glu Leu
2785                2790                2795                2800
Thr Val Thr Gly Ser Ser Pro Asp Ser Leu Ser Leu Ser Trp Thr Ile
                2805                2810                2815    
Pro Gln Gly His Phe Asp Ser Phe Thr Val Gln Tyr Lys Asp Arg Asp
            2820                2825                2830        
Gly Arg Pro Gln Val Met Arg Val Arg Gly Glu Glu Ser Glu Val Thr
        2835                2840                2845            
Val Gly Gly Leu Glu Pro Gly Arg Lys Tyr Lys Met His Leu Tyr Gly
    2850                2855                2860                
Leu His Glu Gly Arg Arg Val Gly Pro Val Ser Thr Val Gly Val Thr
2865                2870                2875                2880
Val Pro Thr Thr Thr Pro Glu Pro Pro Asn Lys Pro Arg Leu Gly Glu
                2885                2890                2895    
Leu Thr Val Thr Asp Ala Thr Pro Asp Ser Leu Ser Leu Ser Trp Met
            2900                2905                2910        
Val Pro Glu Gly Gln Phe Asp His Phe Leu Val Gln Tyr Arg Asn Gly
        2915                2920                2925            
Asp Gly Gln Pro Lys Val Val Arg Val Pro Gly His Glu Asp Gly Val
    2930                2935                2940                
Thr Ile Ser Gly Leu Glu Pro Asp His Lys Tyr Lys Met Asn Leu Tyr
2945                2950                2955                2960
Gly Phe His Gly Gly Gln Arg Val Gly Pro Ile Ser Val Ile Gly Val
                2965                2970                2975    
Thr Glu Glu Glu Thr Pro Ala Pro Thr Glu Pro Ser Thr Glu Ala Pro
            2980                2985                2990        
Glu Pro Pro Glu Glu Pro Leu Leu Gly Glu Leu Thr Val Thr Gly Ser
        2995                3000                3005            
Ser Pro Asp Ser Leu Ser Leu Ser Trp Thr Ile Pro Gln Gly Arg Phe
    3010                3015                3020                
Asp Ser Phe Thr Val Gln Tyr Lys Asp Arg Asp Gly Arg Pro Gln Val
3025                3030                3035                3040
Val Arg Val Arg Gly Glu Glu Ser Glu Val Thr Val Gly Gly Leu Glu
                3045                3050                3055    
Pro Gly Cys Lys Tyr Lys Met His Leu Tyr Gly Leu His Glu Gly Gln
            3060                3065                3070        
Arg Val Gly Pro Val Ser Ala Val Gly Val Thr Ala Pro Lys Asp Glu
        3075                3080                3085            
Ala Glu Thr Thr Gln Ala Val Pro Thr Met Thr Pro Glu Pro Pro Ile
    3090                3095                3100                
Lys Pro Arg Leu Gly Glu Leu Thr Val Thr Asp Ala Thr Pro Asp Ser
3105                3110                3115                3120
Leu Ser Leu Ser Trp Met Val Pro Glu Gly Gln Phe Asp His Phe Leu
                3125                3130                3135    
Val Gln Tyr Arg Asn Gly Asp Gly Gln Pro Lys Ala Val Arg Val Pro
            3140                3145                3150        
Gly His Glu Asp Gly Val Thr Ile Ser Gly Leu Glu Pro Asp His Lys
        3155                3160                3165            
Tyr Lys Met Asn Leu Tyr Gly Phe His Gly Gly Gln Arg Val Gly Pro
    3170                3175                3180                
Val Ser Ala Ile Gly Val Thr Glu Glu Glu Thr Pro Ser Pro Thr Glu
3185                3190                3195                3200
Pro Ser Thr Glu Ala Pro Glu Ala Pro Glu Glu Pro Leu Leu Gly Glu
                3205                3210                3215    
Leu Thr Val Thr Gly Ser Ser Pro Asp Ser Leu Ser Leu Ser Trp Thr
            3220                3225                3230        
Val Pro Gln Gly Arg Phe Asp Ser Phe Thr Val Gln Tyr Lys Asp Arg
        3235                3240                3245            
Asp Gly Gln Pro Gln Val Val Arg Val Arg Gly Glu Glu Ser Glu Val
    3250                3255                3260                
Thr Val Gly Gly Leu Glu Pro Gly Arg Lys Tyr Lys Met His Leu Tyr
3265                3270                3275                3280
Gly Leu His Glu Gly Gln Arg Val Gly Pro Val Ser Thr Val Gly Ile
                3285                3290                3295    
Thr Ala Pro Leu Pro Thr Pro Leu Pro Val Glu Pro Arg Leu Gly Glu
            3300                3305                3310        
Leu Ala Val Ala Ala Val Thr Ser Asp Ser Val Gly Leu Ser Trp Thr
        3315                3320                3325            
Val Ala Gln Gly Pro Phe Asp Ser Phe Leu Val Gln Tyr Arg Asp Ala
    3330                3335                3340                
Gln Gly Gln Pro Gln Ala Val Pro Val Ser Gly Asp Leu Arg Ala Val
3345                3350                3355                3360
Ala Val Ser Gly Leu Asp Pro Ala Arg Lys Tyr Lys Phe Leu Leu Phe
                3365                3370                3375    
Gly Leu Gln Asn Gly Lys Arg His Gly Pro Val Pro Val Glu Ala Arg
            3380                3385                3390        
Thr Ala Pro Asp Thr Lys Pro Ser Pro Arg Leu Gly Glu Leu Thr Val
        3395                3400                3405            
Thr Asp Ala Thr Pro Asp Ser Val Gly Leu Ser Trp Thr Val Pro Glu
    3410                3415                3420                
Gly Glu Phe Asp Ser Phe Val Val Gln Tyr Lys Asp Lys Asp Gly Arg
3425                3430                3435                3440
Leu Gln Val Val Pro Val Ala Ala Asn Gln Arg Glu Val Thr Val Gln
                3445                3450                3455    
Gly Leu Glu Pro Ser Arg Lys Tyr Arg Phe Leu Leu Tyr Gly Leu Ser
            3460                3465                3470        
Gly Arg Lys Arg Leu Gly Pro Ile Ser Ala Asp Ser Thr Thr Ala Pro
        3475                3480                3485            
Leu Glu Lys Glu Leu Pro Pro His Leu Gly Glu Leu Thr Val Ala Glu
    3490                3495                3500                
Glu Thr Ser Ser Ser Leu Arg Leu Ser Trp Thr Val Ala Gln Gly Pro
3505                3510                3515                3520
Phe Asp Ser Phe Val Val Gln Tyr Arg Asp Thr Asp Gly Gln Pro Arg
                3525                3530                3535    
Ala Val Pro Val Ala Ala Asp Gln Arg Thr Val Thr Val Glu Asp Leu
            3540                3545                3550        
Glu Pro Gly Lys Lys Tyr Lys Phe Leu Leu Tyr Gly Leu Leu Gly Gly
        3555                3560                3565            
Lys Arg Leu Gly Pro Val Ser Ala Leu Gly Met Thr Ala Pro Glu Glu
    3570                3575                3580                
Asp Thr Pro Ala Pro Glu Leu Ala Pro Glu Ala Pro Glu Pro Pro Glu
3585                3590                3595                3600
Glu Pro Arg Leu Gly Val Leu Thr Val Thr Asp Thr Thr Pro Asp Ser
                3605                3610                3615    
Met Arg Leu Ser Trp Ser Val Ala Gln Gly Pro Phe Asp Ser Phe Val
            3620                3625                3630        
Val Gln Tyr Glu Asp Thr Asn Gly Gln Pro Gln Ala Leu Leu Val Asp
        3635                3640                3645            
Gly Asp Gln Ser Lys Ile Leu Ile Ser Gly Leu Glu Pro Ser Thr Pro
    3650                3655                3660                
Tyr Arg Phe Leu Leu Tyr Gly Leu His Glu Gly Lys Arg Leu Gly Pro
3665                3670                3675                3680
Leu Ser Ala Glu Gly Thr Thr Gly Leu Ala Pro Ala Gly Gln Thr Ser
                3685                3690                3695    
Glu Glu Ser Arg Pro Arg Leu Ser Gln Leu Ser Val Thr Asp Val Thr
            3700                3705                3710        
Thr Ser Ser Leu Arg Leu Asn Trp Glu Ala Pro Pro Gly Ala Phe Asp
        3715                3720                3725            
Ser Phe Leu Leu Arg Phe Gly Val Pro Ser Pro Ser Thr Leu Glu Pro
    3730                3735                3740                
His Pro Arg Pro Leu Leu Gln Arg Glu Leu Met Val Pro Gly Thr Arg
3745                3750                3755                3760
His Ser Ala Val Leu Arg Asp Leu Arg Ser Gly Thr Leu Tyr Ser Leu
                3765                3770                3775    
Thr Leu Tyr Gly Leu Arg Gly Pro His Lys Ala Asp Ser Ile Gln Gly
            3780                3785                3790        
Thr Ala Arg Thr Leu Ser Pro Val Leu Glu Ser Pro Arg Asp Leu Gln
        3795                3800                3805            
Phe Ser Glu Ile Arg Glu Thr Ser Ala Lys Val Asn Trp Met Pro Pro
    3810                3815                3820                
Pro Ser Arg Ala Asp Ser Phe Lys Val Ser Tyr Gln Leu Ala Asp Gly
3825                3830                3835                3840
Gly Glu Pro Gln Ser Val Gln Val Asp Gly Gln Ala Arg Thr Gln Lys
                3845                3850                3855    
Leu Gln Gly Leu Ile Pro Gly Ala Arg Tyr Glu Val Thr Val Val Ser
            3860                3865                3870        
Val Arg Gly Phe Glu Glu Ser Glu Pro Leu Thr Gly Phe Leu Thr Thr
        3875                3880                3885            
Val Pro Asp Gly Pro Thr Gln Leu Arg Ala Leu Asn Leu Thr Glu Gly
    3890                3895                3900                
Phe Ala Val Leu His Trp Lys Pro Pro Gln Asn Pro Val Asp Thr Tyr
3905                3910                3915                3920
Asp Val Gln Val Thr Ala Pro Gly Ala Pro Pro Leu Gln Ala Glu Thr
                3925                3930                3935    
Pro Gly Ser Ala Val Asp Tyr Pro Leu His Asp Leu Val Leu His Thr
            3940                3945                3950        
Asn Tyr Thr Ala Thr Val Arg Gly Leu Arg Gly Pro Asn Leu Thr Ser
        3955                3960                3965            
Pro Ala Ser Ile Thr Phe Thr Thr Gly Leu Glu Ala Pro Arg Asp Leu
    3970                3975                3980                
Glu Ala Lys Glu Val Thr Pro Arg Thr Ala Leu Leu Thr Trp Thr Glu
3985                3990                3995                4000
Pro Pro Val Arg Pro Ala Gly Tyr Leu Leu Ser Phe His Thr Pro Gly
                4005                4010                4015    
Gly Gln Asn Gln Glu Ile Leu Leu Pro Gly Gly Ile Thr Ser His Gln
            4020                4025                4030        
Leu Leu Gly Leu Phe Pro Ser Thr Ser Tyr Asn Ala Arg Leu Gln Ala
        4035                4040                4045            
Met Trp Gly Gln Ser Leu Leu Pro Pro Val Ser Thr Ser Phe Thr Thr
    4050                4055                4060                
Gly Gly Leu Arg Ile Pro Phe Pro Arg Asp Cys Gly Glu Glu Met Gln
4065                4070                4075                4080
Asn Gly Ala Gly Ala Ser Arg Thr Ser Thr Ile Phe Leu Asn Gly Asn
                4085                4090                4095    
Arg Glu Arg Pro Leu Asn Val Phe Cys Asp Met Glu Thr Asp Gly Gly
            4100                4105                4110        
Gly Trp Leu Val Phe Gln Arg Arg Met Asp Gly Gln Thr Asp Phe Trp
        4115                4120                4125            
Arg Asp Trp Glu Asp Tyr Ala His Gly Phe Gly Asn Ile Ser Gly Glu
    4130                4135                4140                
Phe Trp Leu Gly Asn Glu Ala Leu His Ser Leu Thr Gln Ala Gly Asp
4145                4150                4155                4160
Tyr Ser Met Arg Val Asp Leu Arg Ala Gly Asp Glu Ala Val Phe Ala
                4165                4170                4175    
Gln Tyr Asp Ser Phe His Val Asp Ser Ala Ala Glu Tyr Tyr Arg Leu
            4180                4185                4190        
His Leu Glu Gly Tyr His Gly Thr Ala Gly Asp Ser Met Ser Tyr His
        4195                4200                4205            
Ser Gly Ser Val Phe Ser Ala Arg Asp Arg Asp Pro Asn Ser Leu Leu
    4210                4215                4220                
Ile Ser Cys Ala Val Ser Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys
4225                4230                4235                4240
His Tyr Ala Asn Leu Asn Gly Leu Tyr Gly Ser Thr Val Asp His Gln
                4245                4250                4255    
Gly Val Ser Trp Tyr His Trp Lys Gly Phe Glu Phe Ser Val Pro Phe
            4260                4265                4270        
Thr Glu Met Lys Leu Arg Pro Arg Asn Phe Arg Ser Pro Ala Gly Gly
        4275                4280                4285            
Gly
    


<210> 5956
<211> 673
<212> PRT
<213> Homo sapiens

<400> 5956
Met Arg Leu Ser Trp Ser Val Ala Gln Gly Pro Phe Asp Ser Phe Val
 1               5                  10                  15      
Val Gln Tyr Glu Asp Thr Asn Gly Gln Pro Gln Ala Leu Leu Val Asp
            20                  25                  30          
Gly Asp Gln Ser Lys Ile Leu Ile Ser Gly Leu Glu Pro Ser Thr Pro
        35                  40                  45              
Tyr Arg Phe Leu Leu Tyr Gly Leu His Glu Gly Lys Arg Leu Gly Pro
    50                  55                  60                  
Leu Ser Ala Glu Gly Thr Thr Gly Leu Ala Pro Ala Gly Gln Thr Ser
65                  70                  75                  80  
Glu Glu Ser Arg Pro Arg Leu Ser Gln Leu Ser Val Thr Asp Val Thr
                85                  90                  95      
Thr Ser Ser Leu Arg Leu Asn Trp Glu Ala Pro Pro Gly Ala Phe Asp
            100                 105                 110         
Ser Phe Leu Leu Arg Phe Gly Val Pro Ser Pro Ser Thr Leu Glu Pro
        115                 120                 125             
His Pro Arg Pro Leu Leu Gln Arg Glu Leu Met Val Pro Gly Thr Arg
    130                 135                 140                 
His Ser Ala Val Leu Arg Asp Leu Arg Ser Gly Thr Leu Tyr Ser Leu
145                 150                 155                 160 
Thr Leu Tyr Gly Leu Arg Gly Pro His Lys Ala Asp Ser Ile Gln Gly
                165                 170                 175     
Thr Ala Arg Thr Leu Ser Pro Val Leu Glu Ser Pro Arg Asp Leu Gln
            180                 185                 190         
Phe Ser Glu Ile Arg Glu Thr Ser Ala Lys Val Asn Trp Met Pro Pro
        195                 200                 205             
Pro Ser Arg Ala Asp Ser Phe Lys Val Ser Tyr Gln Leu Ala Asp Gly
    210                 215                 220                 
Gly Glu Pro Gln Ser Val Gln Val Asp Gly Gln Ala Arg Thr Gln Lys
225                 230                 235                 240 
Leu Gln Gly Leu Ile Pro Gly Ala Arg Tyr Glu Val Thr Val Val Ser
                245                 250                 255     
Val Arg Gly Phe Glu Glu Ser Glu Pro Leu Thr Gly Phe Leu Thr Thr
            260                 265                 270         
Val Pro Asp Gly Pro Thr Gln Leu Arg Ala Leu Asn Leu Thr Glu Gly
        275                 280                 285             
Phe Ala Val Leu His Trp Lys Pro Pro Gln Asn Pro Val Asp Thr Tyr
    290                 295                 300                 
Asp Val Gln Val Thr Ala Pro Gly Ala Pro Pro Leu Gln Ala Glu Thr
305                 310                 315                 320 
Pro Gly Ser Ala Val Asp Tyr Pro Leu His Asp Leu Val Leu His Thr
                325                 330                 335     
Asn Tyr Thr Ala Thr Val Arg Gly Leu Arg Gly Pro Asn Leu Thr Ser
            340                 345                 350         
Pro Ala Ser Ile Thr Phe Thr Thr Gly Leu Glu Ala Pro Arg Asp Leu
        355                 360                 365             
Glu Ala Lys Glu Val Thr Pro Arg Thr Ala Leu Leu Thr Trp Thr Glu
    370                 375                 380                 
Pro Pro Val Arg Pro Ala Gly Tyr Leu Leu Ser Phe His Thr Pro Gly
385                 390                 395                 400 
Gly Gln Asn Gln Glu Ile Leu Leu Pro Gly Gly Ile Thr Ser His Gln
                405                 410                 415     
Leu Leu Gly Leu Phe Pro Ser Thr Ser Tyr Asn Ala Arg Leu Gln Ala
            420                 425                 430         
Met Trp Gly Gln Ser Leu Leu Pro Pro Val Ser Thr Ser Phe Thr Thr
        435                 440                 445             
Gly Gly Leu Arg Ile Pro Phe Pro Arg Asp Cys Gly Glu Glu Met Gln
    450                 455                 460                 
Asn Gly Ala Gly Ala Ser Arg Thr Ser Thr Ile Phe Leu Asn Gly Asn
465                 470                 475                 480 
Arg Glu Arg Pro Leu Asn Val Phe Cys Asp Met Glu Thr Asp Gly Gly
                485                 490                 495     
Gly Trp Leu Val Phe Gln Arg Arg Met Asp Gly Gln Thr Asp Phe Trp
            500                 505                 510         
Arg Asp Trp Glu Asp Tyr Ala His Gly Phe Gly Asn Ile Ser Gly Glu
        515                 520                 525             
Phe Trp Leu Gly Asn Glu Ala Leu His Ser Leu Thr Gln Ala Gly Asp
    530                 535                 540                 
Tyr Ser Met Arg Val Asp Leu Arg Ala Gly Asp Glu Ala Val Phe Ala
545                 550                 555                 560 
Gln Tyr Asp Ser Phe His Val Asp Ser Ala Ala Glu Tyr Tyr Arg Leu
                565                 570                 575     
His Leu Glu Gly Tyr His Gly Thr Ala Gly Asp Ser Met Ser Tyr His
            580                 585                 590         
Ser Gly Ser Val Phe Ser Ala Arg Asp Arg Asp Pro Asn Ser Leu Leu
        595                 600                 605             
Ile Ser Cys Ala Val Ser Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys
    610                 615                 620                 
His Tyr Ala Asn Leu Asn Gly Leu Tyr Gly Ser Thr Val Asp His Gln
625                 630                 635                 640 
Gly Val Ser Trp Tyr His Trp Lys Gly Phe Glu Phe Ser Val Pro Phe
                645                 650                 655     
Thr Glu Met Lys Leu Arg Pro Arg Asn Phe Arg Ser Pro Ala Gly Gly
            660                 665                 670         
Gly
    


<210> 5957
<211> 328
<212> PRT
<213> Homo sapiens

<400> 5957
Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala
 1               5                  10                  15      
Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly
            20                  25                  30          
Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg
        35                  40                  45              
Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro
    50                  55                  60                  
Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys
65                  70                  75                  80  
Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln
                85                  90                  95      
Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg
            100                 105                 110         
Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg
        115                 120                 125             
Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro
    130                 135                 140                 
Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile
145                 150                 155                 160 
Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr
                165                 170                 175     
Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu
            180                 185                 190         
Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu
        195                 200                 205             
Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr
    210                 215                 220                 
Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Gly Ala Arg
225                 230                 235                 240 
Pro Gly Trp Arg Asp Gly Gln Ala Gly Gln Thr Glu Lys Asn Gln Lys
                245                 250                 255     
Gly Trp Ser Gly Gln Met Ala Glu Gly Met Gly Gly Ile Trp Ala Met
            260                 265                 270         
Ala Arg Ala Val Gln Pro His Asn Gly Cys Phe Asn Trp Thr Ser Arg
        275                 280                 285             
Ala Arg Gly Arg Lys Gly Ala Phe Val His Leu Gly Leu Glu Gln Ala
    290                 295                 300                 
Arg Gly Lys Pro Glu Pro Trp Val Cys Leu Pro Phe Arg Pro Thr Val
305                 310                 315                 320 
Gly Gly Pro Arg Lys Arg Leu Val
                325             


<210> 5958
<211> 267
<212> PRT
<213> Homo sapiens

<400> 5958
Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro
 1               5                  10                  15      
Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr
            20                  25                  30          
Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys
        35                  40                  45              
Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr
    50                  55                  60                  
Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly
65                  70                  75                  80  
Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu
                85                  90                  95      
Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys
            100                 105                 110         
Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly
        115                 120                 125             
Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala
    130                 135                 140                 
Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu
145                 150                 155                 160 
Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser
                165                 170                 175     
Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly
            180                 185                 190         
Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys
        195                 200                 205             
Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met
    210                 215                 220                 
Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala
225                 230                 235                 240 
Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu
                245                 250                 255     
Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe
            260                 265         


<210> 5959
<211> 337
<212> PRT
<213> Homo sapiens

<400> 5959
Gly Asn Ser Pro Ile Cys Leu Val Leu Ile Leu Gln Ala Val Val Val
 1               5                  10                  15      
Val Glu Cys Lys Arg Gln His Ile Met Glu Thr Gly Pro Glu Asp Pro
            20                  25                  30          
Ser Ser Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile
        35                  40                  45              
Pro Tyr Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu
    50                  55                  60                  
Phe Cys Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe
65                  70                  75                  80  
Val Ser His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala
                85                  90                  95      
Arg Met Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val
            100                 105                 110         
Gly His Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His
        115                 120                 125             
Val Phe Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp
    130                 135                 140                 
Tyr Pro Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala
145                 150                 155                 160 
Ile Ala Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met
                165                 170                 175     
Val Leu Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr
            180                 185                 190         
Phe Lys Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu
        195                 200                 205             
Ser Leu Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Thr Glu
    210                 215                 220                 
Val Asp Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys
225                 230                 235                 240 
Val Cys Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg
                245                 250                 255     
Ala Leu Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala
            260                 265                 270         
Asp Arg Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala
        275                 280                 285             
Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val
    290                 295                 300                 
Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile
305                 310                 315                 320 
Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro
                325                 330                 335     
Pro
    


<210> 5960
<211> 486
<212> PRT
<213> Homo sapiens

<400> 5960
Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro
 1               5                  10                  15      
Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys
            20                  25                  30          
Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala
        35                  40                  45              
Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu
    50                  55                  60                  
Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met
65                  70                  75                  80  
Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu
                85                  90                  95      
Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe
            100                 105                 110         
Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly
        115                 120                 125             
Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp
    130                 135                 140                 
Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys
145                 150                 155                 160 
Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn
                165                 170                 175     
Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser
            180                 185                 190         
Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val
        195                 200                 205             
Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser
    210                 215                 220                 
Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr
225                 230                 235                 240 
Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met
                245                 250                 255     
Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu
            260                 265                 270         
Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val
        275                 280                 285             
Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys
    290                 295                 300                 
Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln
305                 310                 315                 320 
Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His Phe Asp His
                325                 330                 335     
Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly Gly Asp Tyr
            340                 345                 350         
Asp Gly Ala Gly Lys Phe Pro Gln Gly Leu Glu Asp Val Ser Thr Tyr
        355                 360                 365             
Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Gly Trp Ser Glu Glu Glu
    370                 375                 380                 
Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln Val
385                 390                 395                 400 
Glu Lys Val Gln Glu Glu Asn Lys Trp Gln Ser Pro Leu Glu Asp Lys
                405                 410                 415     
Phe Pro Asp Glu Gln Leu Ser Ser Ser Cys His Ser Asp Leu Ser Arg
            420                 425                 430         
Leu Arg Gln Arg Gln Ser Leu Thr Ser Gly Gln Glu Leu Thr Glu Ile
        435                 440                 445             
Pro Ile His Trp Thr Ala Lys Leu Pro Ala Lys Trp Ser Val Ser Glu
    450                 455                 460                 
Ser Ser Pro His Met Ala Pro Val Leu Ala Val Val Ala Thr Phe Pro
465                 470                 475                 480 
Val Leu Ile Leu Trp Leu
                485     


<210> 5961
<211> 399
<212> PRT
<213> Homo sapiens

<400> 5961
Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro
 1               5                  10                  15      
Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys
            20                  25                  30          
Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Gln Phe Trp Ser Ala Tyr
        35                  40                  45              
Val Pro Cys Gln Thr Gln Asp Arg Asp Ala Leu Arg Leu Thr Leu Glu
    50                  55                  60                  
Gln Ile Asp Leu Ile Arg Arg Met Cys Ala Ser Tyr Ser Glu Leu Glu
65                  70                  75                  80  
Leu Val Thr Ser Ala Lys Ala Leu Asn Asp Thr Gln Lys Leu Ala Cys
                85                  90                  95      
Leu Ile Gly Val Glu Gly Gly His Ser Leu Asp Asn Ser Leu Ser Ile
            100                 105                 110         
Leu Arg Thr Phe Tyr Met Leu Gly Val Arg Tyr Leu Thr Leu Thr His
        115                 120                 125             
Thr Cys Asn Thr Pro Trp Ala Glu Ser Ser Ala Lys Gly Val His Ser
    130                 135                 140                 
Phe Tyr Asn Asn Ile Ser Gly Leu Thr Asp Phe Gly Glu Lys Val Val
145                 150                 155                 160 
Ala Glu Met Asn Arg Leu Gly Met Met Val Asp Leu Ser His Val Ser
                165                 170                 175     
Asp Ala Val Ala Arg Arg Ala Leu Glu Val Ser Gln Ala Pro Val Ile
            180                 185                 190         
Phe Ser His Ser Ala Ala Arg Gly Val Cys Asn Ser Ala Arg Asn Val
        195                 200                 205             
Pro Asp Asp Ile Leu Gln Leu Leu Lys Lys Asn Gly Gly Val Val Met
    210                 215                 220                 
Val Ser Leu Ser Met Gly Val Ile Gln Cys Asn Pro Ser Ala Asn Val
225                 230                 235                 240 
Ser Thr Val Ala Asp His Phe Asp His Ile Lys Ala Val Ile Gly Ser
                245                 250                 255     
Lys Phe Ile Gly Ile Gly Gly Asp Tyr Asp Gly Ala Gly Lys Phe Pro
            260                 265                 270         
Gln Gly Leu Glu Asp Val Ser Thr Tyr Pro Val Leu Ile Glu Glu Leu
        275                 280                 285             
Leu Ser Arg Gly Trp Ser Glu Glu Glu Leu Gln Gly Val Leu Arg Gly
    290                 295                 300                 
Asn Leu Leu Arg Val Phe Arg Gln Val Glu Lys Val Gln Glu Glu Asn
305                 310                 315                 320 
Lys Trp Gln Ser Pro Leu Glu Asp Lys Phe Pro Asp Glu Gln Leu Ser
                325                 330                 335     
Ser Ser Cys His Ser Asp Leu Ser Arg Leu Arg Gln Arg Gln Ser Leu
            340                 345                 350         
Thr Ser Gly Gln Glu Leu Thr Glu Ile Pro Ile His Trp Thr Ala Lys
        355                 360                 365             
Leu Pro Ala Lys Trp Ser Val Ser Glu Ser Ser Pro His Met Ala Pro
    370                 375                 380                 
Val Leu Ala Val Val Ala Thr Phe Pro Val Leu Ile Leu Trp Leu
385                 390                 395                 


<210> 5962
<211> 179
<212> PRT
<213> Homo sapiens

<400> 5962
Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu
 1               5                  10                  15      
Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala
            20                  25                  30          
Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln
        35                  40                  45              
Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser
    50                  55                  60                  
Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe
65                  70                  75                  80  
His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu
                85                  90                  95      
Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln
            100                 105                 110         
Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg
        115                 120                 125             
Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn
    130                 135                 140                 
Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu
145                 150                 155                 160 
Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn
                165                 170                 175     
Ala Cys Ile
            


<210> 5963
<211> 520
<212> PRT
<213> Homo sapiens

<400> 5963
Met Arg Asn Lys Lys Ile Leu Lys Glu Asp Glu Leu Leu Ser Glu Thr
 1               5                  10                  15      
Gln Gln Ala Ala Phe His Gln Ile Ala Met Glu Pro Phe Glu Ile Asn
            20                  25                  30          
Val Pro Lys Pro Lys Arg Arg Asn Gly Val Asn Phe Ser Leu Ala Val
        35                  40                  45              
Val Val Ile Tyr Leu Ile Leu Leu Thr Ala Gly Ala Gly Leu Leu Val
    50                  55                  60                  
Val Gln Val Leu Asn Leu Gln Ala Arg Leu Arg Val Leu Glu Met Tyr
65                  70                  75                  80  
Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu
                85                  90                  95      
Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly Ala Ser Arg
            100                 105                 110         
Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser His Glu
        115                 120                 125             
His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe
    130                 135                 140                 
Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His Lys Gly
145                 150                 155                 160 
Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu
                165                 170                 175     
Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly Pro Ser
            180                 185                 190         
Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu Gln Gly
        195                 200                 205             
Pro Gln Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr Pro Gly Pro
    210                 215                 220                 
Gln Gly Glu Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile Gly Pro Lys
225                 230                 235                 240 
Gly Glu Thr Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly Leu Pro Gly
                245                 250                 255     
Ser Lys Gly Asp Arg Gly Met Lys Gly Asp Ala Gly Val Met Gly Pro
            260                 265                 270         
Pro Gly Ala Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro Gly Pro Pro
        275                 280                 285             
Gly Leu Ala Gly Phe Pro Gly Ala Lys Gly Asp Gln Gly Gln Pro Gly
    290                 295                 300                 
Leu Gln Gly Val Pro Gly Pro Pro Gly Ala Val Gly His Pro Gly Ala
305                 310                 315                 320 
Lys Gly Glu Pro Gly Ser Ala Gly Ser Pro Gly Arg Ala Gly Leu Pro
                325                 330                 335     
Gly Ser Pro Gly Ser Pro Gly Ala Thr Gly Leu Lys Gly Ser Lys Gly
            340                 345                 350         
Asp Thr Gly Leu Gln Gly Gln Gln Gly Arg Lys Gly Glu Ser Gly Val
        355                 360                 365             
Pro Gly Pro Ala Gly Val Lys Gly Glu Gln Gly Ser Pro Gly Leu Ala
    370                 375                 380                 
Gly Pro Lys Gly Ala Pro Gly Gln Ala Gly Gln Lys Gly Asp Gln Gly
385                 390                 395                 400 
Val Lys Gly Ser Ser Gly Glu Gln Gly Val Lys Gly Glu Lys Gly Glu
                405                 410                 415     
Arg Gly Glu Asn Ser Val Ser Val Arg Ile Val Gly Ser Ser Asn Arg
            420                 425                 430         
Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp
        435                 440                 445             
Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe Cys Arg Met Leu Gly
    450                 455                 460                 
Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln
465                 470                 475                 480 
Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp
                485                 490                 495     
Ser Cys Thr Lys Asn Ser Trp Gly His His Asp Cys Ser His Glu Glu
            500                 505                 510         
Asp Ala Gly Val Glu Cys Ser Val
        515                 520 


<210> 5964
<211> 976
<212> PRT
<213> Homo sapiens

<400> 5964
Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu
 1               5                  10                  15      
Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly
            20                  25                  30          
Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val
        35                  40                  45              
Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val
    50                  55                  60                  
Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn
65                  70                  75                  80  
Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr
                85                  90                  95      
Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg
            100                 105                 110         
Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu
        115                 120                 125             
Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr
    130                 135                 140                 
Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu
145                 150                 155                 160 
Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys
                165                 170                 175     
Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly
            180                 185                 190         
Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe
        195                 200                 205             
Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg
    210                 215                 220                 
Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser
225                 230                 235                 240 
Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln
                245                 250                 255     
Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln
            260                 265                 270         
Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe
        275                 280                 285             
Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr
    290                 295                 300                 
Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn
305                 310                 315                 320 
Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu
                325                 330                 335     
Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn
            340                 345                 350         
Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu
        355                 360                 365             
Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly
    370                 375                 380                 
Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn
385                 390                 395                 400 
Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu
                405                 410                 415     
Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly
            420                 425                 430         
Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln
        435                 440                 445             
Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser
    450                 455                 460                 
Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser
465                 470                 475                 480 
Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp
                485                 490                 495     
Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn
            500                 505                 510         
Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly
        515                 520                 525             
Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr
    530                 535                 540                 
Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val
545                 550                 555                 560 
Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu
                565                 570                 575     
Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly
            580                 585                 590         
Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala
        595                 600                 605             
Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met
    610                 615                 620                 
Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu
625                 630                 635                 640 
Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu
                645                 650                 655     
Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr
            660                 665                 670         
Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser
        675                 680                 685             
Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys
    690                 695                 700                 
Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu
705                 710                 715                 720 
Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala
                725                 730                 735     
Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val
            740                 745                 750         
Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp
        755                 760                 765             
Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala
    770                 775                 780                 
Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu
785                 790                 795                 800 
Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp
                805                 810                 815     
Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro
            820                 825                 830         
Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe
        835                 840                 845             
Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser
    850                 855                 860                 
Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr
865                 870                 875                 880 
Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro
                885                 890                 895     
Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu
            900                 905                 910         
Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile
        915                 920                 925             
Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro
    930                 935                 940                 
Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val
945                 950                 955                 960 
Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val
                965                 970                 975     


<210> 5965
<211> 539
<212> PRT
<213> Homo sapiens

<400> 5965
Met Gly Ser Pro Val Ser His Leu Leu Ala Gly Phe Cys Val Trp Val
 1               5                  10                  15      
Val Leu Gly Trp Val Gly Gly Ser Val Pro Asn Leu Gly Pro Ala Glu
            20                  25                  30          
Gln Glu Gln Asn His Tyr Leu Ala Gln Leu Phe Gly Leu Tyr Gly Glu
        35                  40                  45              
Asn Gly Thr Leu Thr Ala Gly Gly Leu Ala Arg Leu Leu His Ser Leu
    50                  55                  60                  
Gly Leu Gly Arg Val Gln Gly Leu Arg Leu Gly Gln His Gly Pro Leu
65                  70                  75                  80  
Thr Gly Arg Ala Ala Ser Pro Ala Ala Asp Asn Ser Thr His Arg Pro
                85                  90                  95      
Gln Asn Pro Glu Leu Ser Val Asp Val Trp Ala Gly Met Pro Leu Gly
            100                 105                 110         
Pro Ser Gly Trp Gly Asp Leu Glu Glu Ser Lys Ala Pro His Leu Pro
        115                 120                 125             
Arg Gly Pro Ala Pro Ser Gly Leu Asp Leu Leu His Arg Leu Leu Leu
    130                 135                 140                 
Leu Asp His Ser Leu Ala Asp His Leu Asn Glu Asp Cys Leu Asn Gly
145                 150                 155                 160 
Ser Gln Leu Leu Val Asn Phe Gly Leu Ser Pro Ala Ala Pro Leu Thr
                165                 170                 175     
Pro Arg Gln Phe Ala Leu Leu Cys Pro Ala Leu Leu Tyr Gln Ile Asp
            180                 185                 190         
Ser Arg Val Cys Ile Gly Ala Pro Ala Pro Ala Pro Pro Gly Asp Leu
        195                 200                 205             
Leu Ser Ala Leu Leu Gln Ser Ala Leu Ala Val Leu Leu Leu Ser Leu
    210                 215                 220                 
Pro Ser Pro Leu Ser Leu Leu Leu Leu Arg Leu Leu Gly Pro Arg Leu
225                 230                 235                 240 
Leu Arg Pro Leu Leu Gly Phe Leu Gly Ala Leu Ala Val Gly Thr Leu
                245                 250                 255     
Cys Gly Asp Ala Leu Leu His Leu Leu Pro His Ala Gln Glu Gly Arg
            260                 265                 270         
His Ala Gly Pro Gly Gly Leu Pro Glu Lys Asp Leu Gly Pro Gly Leu
        275                 280                 285             
Ser Val Leu Gly Gly Leu Phe Leu Leu Phe Val Leu Glu Asn Met Leu
    290                 295                 300                 
Gly Leu Leu Arg His Arg Gly Leu Arg Pro Arg Cys Cys Arg Arg Lys
305                 310                 315                 320 
Arg Arg Asn Leu Glu Thr Arg Asn Leu Asp Pro Glu Asn Gly Ser Gly
                325                 330                 335     
Met Ala Leu Gln Pro Leu Gln Ala Ala Pro Glu Pro Gly Ala Gln Gly
            340                 345                 350         
Gln Arg Glu Lys Asn Ser Gln His Pro Pro Ala Leu Ala Pro Pro Gly
        355                 360                 365             
His Gln Gly His Ser His Gly His Gln Gly Gly Thr Asp Ile Thr Trp
    370                 375                 380                 
Met Val Leu Leu Gly Asp Gly Leu His Asn Leu Thr Asp Gly Leu Ala
385                 390                 395                 400 
Ile Gly Ala Ala Phe Ser Asp Gly Phe Ser Ser Gly Leu Ser Thr Thr
                405                 410                 415     
Leu Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala
            420                 425                 430         
Met Leu Leu Gln Ser Gly Leu Ser Phe Arg Arg Leu Leu Leu Leu Ser
        435                 440                 445             
Leu Val Ser Gly Ala Leu Gly Leu Gly Gly Ala Val Leu Gly Val Gly
    450                 455                 460                 
Leu Ser Leu Gly Pro Val Pro Leu Thr Pro Trp Val Phe Gly Val Thr
465                 470                 475                 480 
Ala Gly Val Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Ala Leu
                485                 490                 495     
Leu Arg Pro Pro Glu Pro Leu Pro Thr Pro His Val Leu Leu Gln Gly
            500                 505                 510         
Leu Gly Leu Leu Leu Gly Gly Gly Leu Met Leu Ala Ile Thr Leu Leu
        515                 520                 525             
Glu Glu Arg Leu Leu Pro Val Thr Thr Glu Gly
    530                 535                 


<210> 5966
<211> 831
<212> PRT
<213> Homo sapiens

<400> 5966
Met Gly Glu Leu Phe Arg Ser Glu Glu Met Thr Leu Ala Gln Leu Phe
 1               5                  10                  15      
Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu
            20                  25                  30          
Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln
        35                  40                  45              
Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys
    50                  55                  60                  
Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met
65                  70                  75                  80  
Asp Thr Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp
                85                  90                  95      
Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn
            100                 105                 110         
Thr Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Thr Glu Leu
        115                 120                 125             
Lys Phe Ile Leu Arg Lys Thr Gln Gln Phe Phe Asp Glu Met Ala Asp
    130                 135                 140                 
Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu Glu Pro Ser Glu Met
145                 150                 155                 160 
Gly Arg Gly Thr Pro Leu Arg Leu Gly Phe Val Ala Gly Val Ile Asn
                165                 170                 175     
Arg Glu Arg Ile Pro Thr Phe Glu Arg Met Leu Trp Arg Val Cys Arg
            180                 185                 190         
Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu Asn Pro Leu Glu Asp
        195                 200                 205             
Pro Val Thr Gly Asp Tyr Val His Lys Ser Val Phe Ile Ile Phe Phe
    210                 215                 220                 
Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys Ile Cys Glu Gly Phe
225                 230                 235                 240 
Arg Ala Ser Leu Tyr Pro Cys Pro Glu Thr Pro Gln Glu Arg Lys Glu
                245                 250                 255     
Met Ala Ser Gly Val Asn Thr Arg Ile Asp Asp Leu Gln Met Val Leu
            260                 265                 270         
Asn Gln Thr Glu Asp His Arg Gln Arg Val Leu Gln Ala Ala Ala Lys
        275                 280                 285             
Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys Met Lys Ala Ile Tyr
    290                 295                 300                 
His Thr Leu Asn Leu Cys Asn Ile Asp Val Thr Gln Lys Cys Leu Ile
305                 310                 315                 320 
Ala Glu Val Trp Cys Pro Val Thr Asp Leu Asp Ser Ile Gln Phe Ala
                325                 330                 335     
Leu Arg Arg Gly Thr Glu His Ser Gly Ser Thr Val Pro Ser Ile Leu
            340                 345                 350         
Asn Arg Met Gln Thr Asn Gln Thr Pro Pro Thr Tyr Asn Lys Thr Asn
        355                 360                 365             
Lys Phe Thr Tyr Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly Ile Gly
    370                 375                 380                 
Thr Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr Phe Pro
385                 390                 395                 400 
Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly His Gly Ile Leu Met
                405                 410                 415     
Thr Leu Phe Ala Val Trp Met Val Leu Arg Glu Ser Arg Ile Leu Ser
            420                 425                 430         
Gln Lys Asn Glu Asn Glu Met Phe Ser Thr Val Phe Ser Gly Arg Tyr
        435                 440                 445             
Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr Thr Gly Leu Ile Tyr
    450                 455                 460                 
Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser Trp Ser
465                 470                 475                 480 
Val Arg Pro Met Phe Thr Tyr Asn Trp Thr Glu Glu Thr Leu Arg Gly
                485                 490                 495     
Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro Gly Val Phe Gly Gly
            500                 505                 510         
Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Ile Ala Thr Asn Lys
        515                 520                 525             
Leu Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly
    530                 535                 540                 
Ile Ile His Met Leu Phe Gly Val Ser Leu Ser Leu Phe Asn His Ile
545                 550                 555                 560 
Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly Phe Ile Pro Glu Ile
                565                 570                 575     
Ile Phe Met Thr Ser Leu Phe Gly Tyr Leu Val Ile Leu Ile Phe Tyr
            580                 585                 590         
Lys Trp Thr Ala Tyr Asp Ala His Thr Ser Glu Asn Ala Pro Ser Leu
        595                 600                 605             
Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly
    610                 615                 620                 
Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val
625                 630                 635                 640 
Val Val Ala Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu
                645                 650                 655     
Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Thr Leu Asn
            660                 665                 670         
Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Thr Glu Glu Asp Ala Glu
        675                 680                 685             
Ile Ile Gln His Asp Gln Leu Ser Thr His Ser Glu Asp Ala Asp Glu
    690                 695                 700                 
Phe Asp Phe Gly Asp Thr Met Val His Gln Ala Ile His Thr Ile Glu
705                 710                 715                 720 
Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser Tyr Leu Arg Leu Trp
                725                 730                 735     
Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp Thr Met
            740                 745                 750         
Val Ile His Ile Gly Leu Ser Val Lys Ser Leu Ala Gly Gly Leu Val
        755                 760                 765             
Leu Phe Phe Phe Phe Thr Ala Phe Ala Thr Leu Thr Val Ala Ile Leu
    770                 775                 780                 
Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His Ala Leu Arg Leu His
785                 790                 795                 800 
Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Thr Gly Phe Lys Phe
                805                 810                 815     
Leu Pro Phe Ser Phe Glu His Ile Arg Glu Gly Lys Phe Glu Glu
            820                 825                 830     


<210> 5967
<211> 408
<212> PRT
<213> Homo sapiens

<400> 5967
Met Ala Gly Arg Gly Phe Ser Trp Gly Pro Gly His Leu Asn Glu Asp
 1               5                  10                  15      
Asn Ala Arg Phe Leu Leu Leu Ala Ala Leu Ile Val Leu Tyr Leu Leu
            20                  25                  30          
Gly Gly Ala Ala Val Phe Ser Ala Leu Glu Leu Ala His Glu Arg Gln
        35                  40                  45              
Ala Lys Gln Arg Trp Glu Glu Arg Leu Ala Asn Phe Ser Arg Gly His
    50                  55                  60                  
Asn Leu Ser Arg Asp Glu Leu Arg Gly Phe Leu Arg His Tyr Glu Glu
65                  70                  75                  80  
Ala Thr Arg Ala Gly Ile Arg Val Asp Asn Val Arg Pro Arg Trp Asp
                85                  90                  95      
Phe Thr Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser Thr Ile Gly
            100                 105                 110         
Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ile Phe Leu Ile
        115                 120                 125             
Phe Tyr Gly Leu Val Gly Cys Ser Ser Thr Ile Leu Phe Phe Asn Leu
    130                 135                 140                 
Phe Leu Glu Arg Leu Ile Thr Ile Ile Ala Tyr Ile Met Lys Ser Cys
145                 150                 155                 160 
His Gln Arg Gln Leu Arg Arg Arg Gly Ala Leu Pro Gln Glu Ser Leu
                165                 170                 175     
Lys Asp Ala Gly Gln Cys Glu Val Asp Ser Leu Ala Gly Trp Lys Pro
            180                 185                 190         
Ser Val Tyr Tyr Val Met Leu Ile Leu Cys Thr Ala Ser Ile Leu Ile
        195                 200                 205             
Ser Cys Cys Ala Ser Ala Met Tyr Thr Pro Ile Glu Gly Trp Ser Tyr
    210                 215                 220                 
Phe Asp Ser Leu Tyr Phe Cys Phe Val Ala Phe Ser Thr Ile Gly Phe
225                 230                 235                 240 
Gly Asp Leu Val Ser Ser Gln Asn Ala His Tyr Glu Ser Gln Gly Leu
                245                 250                 255     
Tyr Arg Phe Ala Asn Phe Val Phe Ile Leu Met Gly Val Cys Cys Ile
            260                 265                 270         
Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln Ser Leu Asn
        275                 280                 285             
Trp Ile Leu Arg Lys Met Asp Ser Gly Cys Cys Pro Gln Cys Gln Arg
    290                 295                 300                 
Gly Leu Leu Arg Ser Arg Arg Asn Val Val Met Pro Gly Ser Val Arg
305                 310                 315                 320 
Asn Arg Cys Asn Ile Ser Ile Glu Thr Asp Gly Val Ala Glu Ser Asp
                325                 330                 335     
Thr Asp Gly Arg Arg Leu Ser Gly Glu Met Ile Ser Met Lys Asp Leu
            340                 345                 350         
Leu Ala Ala Asn Lys Ala Ser Leu Ala Ile Leu Gln Lys Gln Leu Ser
        355                 360                 365             
Glu Met Ala Asn Gly Cys Pro His Gln Thr Ser Thr Leu Ala Arg Asp
    370                 375                 380                 
Asn Glu Phe Ser Gly Gly Val Gly Ala Phe Ala Ile Met Asn Asn Arg
385                 390                 395                 400 
Leu Ala Glu Thr Ser Gly Asp Arg
                405             


<210> 5968
<211> 1200
<212> PRT
<213> Homo sapiens

<400> 5968
Met Gly Glu Lys Leu Ser Gly Lys Leu Ser Pro Cys Leu Arg Arg Gly
 1               5                  10                  15      
Val Ala Gln Gln Pro Arg Cys Ala Gly Glu Glu Asn Trp Val Asp Ser
            20                  25                  30          
Arg Thr Ile Tyr Val Gly His Arg Glu Pro Pro Pro Gly Ala Glu Ala
        35                  40                  45              
Tyr Ile Pro Gln Arg Tyr Pro Asp Asn Arg Ile Val Ser Ser Lys Tyr
    50                  55                  60                  
Thr Phe Trp Asn Phe Ile Pro Lys Asn Leu Phe Glu Gln Phe Arg Arg
65                  70                  75                  80  
Val Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu Val Gln Leu Ile Ile
                85                  90                  95      
Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu Pro Leu Phe Phe Val
            100                 105                 110         
Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu Asp Trp Leu Arg His
        115                 120                 125             
Lys Ala Asp Asn Ala Met Asn Gln Cys Pro Val His Phe Ile Gln His
    130                 135                 140                 
Gly Lys Leu Val Arg Lys Gln Ser Arg Lys Leu Arg Val Gly Asp Ile
145                 150                 155                 160 
Val Met Val Lys Glu Asp Glu Thr Phe Pro Cys Asp Leu Ile Phe Leu
                165                 170                 175     
Ser Ser Asn Arg Gly Asp Gly Thr Cys His Val Thr Thr Ala Ser Leu
            180                 185                 190         
Asp Gly Glu Ser Ser His Lys Thr His Tyr Ala Val Gln Asp Thr Lys
        195                 200                 205             
Gly Phe His Thr Glu Glu Asp Ile Gly Gly Leu His Ala Thr Ile Glu
    210                 215                 220                 
Cys Glu Gln Pro Gln Pro Asp Leu Tyr Lys Phe Val Gly Arg Ile Asn
225                 230                 235                 240 
Val Tyr Ser Asp Leu Asn Asp Pro Val Val Arg Pro Leu Gly Ser Glu
                245                 250                 255     
Asn Leu Leu Leu Arg Gly Ala Thr Leu Lys Asn Thr Glu Lys Ile Phe
            260                 265                 270         
Gly Val Ala Ile Tyr Thr Gly Met Glu Thr Lys Met Ala Leu Asn Tyr
        275                 280                 285             
Gln Ser Lys Ser Gln Lys Arg Ser Ala Val Glu Lys Ser Met Asn Ala
    290                 295                 300                 
Phe Leu Ile Val Tyr Leu Cys Ile Leu Ile Ser Lys Ala Leu Ile Asn
305                 310                 315                 320 
Thr Val Leu Lys Tyr Met Trp Gln Ser Glu Pro Phe Arg Asp Glu Pro
                325                 330                 335     
Trp Tyr Asn Gln Lys Thr Glu Ser Glu Arg Gln Arg Asn Leu Phe Leu
            340                 345                 350         
Lys Ala Phe Thr Asp Phe Leu Ala Phe Met Val Leu Phe Asn Tyr Ile
        355                 360                 365             
Ile Pro Val Ser Met Tyr Val Thr Val Glu Met Gln Lys Phe Leu Gly
    370                 375                 380                 
Ser Tyr Phe Ile Thr Trp Asp Glu Asp Met Phe Asp Glu Glu Thr Gly
385                 390                 395                 400 
Glu Gly Pro Leu Val Asn Thr Ser Asp Leu Asn Glu Glu Leu Gly Gln
                405                 410                 415     
Val Glu Tyr Ile Phe Thr Asp Lys Thr Gly Thr Leu Thr Glu Asn Asn
            420                 425                 430         
Met Glu Phe Lys Glu Cys Cys Ile Glu Gly His Val Tyr Val Pro His
        435                 440                 445             
Val Ile Cys Asn Gly Gln Val Leu Pro Glu Ser Ser Gly Ile Asp Met
    450                 455                 460                 
Ile Asp Ser Ser Pro Ser Val Asn Gly Arg Glu Arg Glu Glu Leu Phe
465                 470                 475                 480 
Phe Arg Ala Leu Cys Leu Cys His Thr Val Gln Val Lys Asp Asp Asp
                485                 490                 495     
Ser Val Asp Gly Pro Arg Lys Ser Pro Asp Gly Gly Lys Ser Cys Val
            500                 505                 510         
Tyr Ile Ser Ser Ser Pro Asp Glu Val Ala Leu Val Glu Gly Val Gln
        515                 520                 525             
Arg Leu Gly Phe Thr Tyr Leu Arg Leu Lys Asp Asn Tyr Met Glu Ile
    530                 535                 540                 
Leu Asn Arg Glu Asn His Ile Glu Arg Phe Glu Leu Leu Glu Ile Leu
545                 550                 555                 560 
Ser Phe Asp Ser Val Arg Arg Arg Met Ser Val Ile Val Lys Ser Ala
                565                 570                 575     
Thr Gly Glu Ile Tyr Leu Phe Cys Lys Gly Ala Asp Ser Ser Ile Phe
            580                 585                 590         
Pro Arg Val Ile Glu Gly Lys Val Asp Gln Ile Arg Ala Arg Val Glu
        595                 600                 605             
Arg Asn Ala Val Glu Gly Leu Arg Thr Leu Cys Val Ala Tyr Lys Arg
    610                 615                 620                 
Leu Ile Gln Glu Glu Tyr Glu Gly Ile Cys Lys Leu Leu Gln Ala Ala
625                 630                 635                 640 
Lys Val Ala Leu Gln Asp Arg Glu Lys Lys Leu Ala Glu Ala Tyr Glu
                645                 650                 655     
Gln Ile Glu Lys Asp Leu Thr Leu Leu Gly Ala Thr Ala Val Glu Asp
            660                 665                 670         
Arg Leu Gln Glu Lys Ala Ala Asp Thr Ile Glu Ala Leu Gln Lys Ala
        675                 680                 685             
Gly Ile Lys Val Trp Val Leu Thr Gly Asp Lys Met Glu Thr Ala Ala
    690                 695                 700                 
Ala Thr Cys Tyr Ala Cys Lys Leu Phe Arg Arg Asn Thr Gln Leu Leu
705                 710                 715                 720 
Glu Leu Thr Thr Lys Arg Ile Glu Glu Gln Ser Leu His Asp Val Leu
                725                 730                 735     
Phe Glu Leu Ser Lys Thr Val Leu Arg His Ser Gly Ser Leu Thr Arg
            740                 745                 750         
Asp Asn Leu Ser Gly Leu Ser Ala Asp Met Gln Asp Tyr Gly Leu Ile
        755                 760                 765             
Ile Asp Gly Ala Ala Leu Ser Leu Ile Met Lys Pro Arg Glu Asp Gly
    770                 775                 780                 
Ser Ser Gly Asn Tyr Arg Glu Leu Phe Leu Glu Ile Cys Arg Ser Cys
785                 790                 795                 800 
Ser Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys Ala Gln Ile
                805                 810                 815     
Val Lys Leu Ile Lys Phe Ser Lys Glu His Pro Ile Thr Leu Ala Ile
            820                 825                 830         
Gly Asp Gly Ala Asn Asp Val Ser Met Ile Leu Glu Ala His Val Gly
        835                 840                 845             
Ile Gly Val Ile Gly Lys Glu Gly Arg Gln Ala Ala Arg Asn Ser Asp
    850                 855                 860                 
Tyr Ala Ile Pro Lys Phe Lys His Leu Lys Lys Met Leu Leu Val His
865                 870                 875                 880 
Gly His Phe Tyr Tyr Ile Arg Ile Ser Glu Leu Val Gln Tyr Phe Phe
                885                 890                 895     
Tyr Lys Asn Val Cys Phe Ile Phe Pro Gln Phe Leu Tyr Gln Phe Phe
            900                 905                 910         
Cys Gly Phe Ser Gln Gln Thr Leu Tyr Asp Thr Ala Tyr Leu Thr Leu
        915                 920                 925             
Tyr Asn Ile Ser Phe Thr Ser Leu Pro Ile Leu Leu Tyr Ser Leu Met
    930                 935                 940                 
Glu Gln His Val Gly Ile Asp Val Leu Lys Arg Asp Pro Thr Leu Tyr
945                 950                 955                 960 
Arg Asp Val Ala Lys Asn Ala Leu Leu Arg Trp Arg Val Phe Ile Tyr
                965                 970                 975     
Trp Thr Leu Leu Gly Leu Phe Asp Ala Leu Val Phe Phe Phe Gly Ala
            980                 985                 990         
Tyr Phe Val Phe Glu Asn Thr Thr Val Thr Ser Asn Gly Gln Ile Phe
        995                 1000                1005            
Gly Asn Trp Thr Phe Gly Thr Leu Val Phe Thr Val Met Val Phe Thr
    1010                1015                1020                
Val Thr Leu Lys Leu Ala Leu Asp Thr His Tyr Trp Thr Trp Ile Asn
1025                1030                1035                1040
His Phe Val Ile Trp Gly Ser Leu Leu Phe Tyr Val Val Phe Ser Leu
                1045                1050                1055    
Leu Trp Gly Gly Val Ile Trp Pro Phe Leu Asn Tyr Gln Arg Met Tyr
            1060                1065                1070        
Tyr Val Phe Ile Gln Met Leu Ser Ser Gly Pro Ala Trp Leu Ala Ile
        1075                1080                1085            
Val Leu Leu Val Thr Ile Ser Leu Leu Pro Asp Val Leu Lys Lys Val
    1090                1095                1100                
Leu Cys Arg Gln Leu Trp Pro Thr Ala Thr Glu Arg Val Gln Asn Gly
1105                1110                1115                1120
Cys Ala Gln Pro Arg Asp Arg Asp Ser Glu Phe Thr Pro Leu Ala Ser
                1125                1130                1135    
Leu Gln Ser Pro Gly Tyr Gln Ser Thr Cys Pro Ser Ala Ala Trp Tyr
            1140                1145                1150        
Ser Ser His Ser Gln Gln Val Thr Leu Ala Ala Trp Lys Glu Lys Val
        1155                1160                1165            
Ser Thr Glu Pro Pro Pro Ile Leu Gly Gly Ser His His His Cys Ser
    1170                1175                1180                
Ser Ile Pro Ser His Ser Cys Pro Arg Ser Arg Val Gly Met Leu Val
1185                1190                1195                1200


<210> 5969
<211> 718
<212> PRT
<213> Homo sapiens

<400> 5969
Met Leu Val His Leu Phe Arg Val Gly Ile Arg Gly Gly Pro Phe Pro
 1               5                  10                  15      
Gly Arg Leu Leu Pro Pro Leu Arg Phe Gln Thr Phe Ser Ala Val Arg
            20                  25                  30          
Tyr Ser Asp Gly Tyr Arg Ser Ser Ser Leu Leu Arg Ala Val Ala His
        35                  40                  45              
Leu Arg Ser Gln Leu Trp Ala His Leu Pro Arg Ala Pro Leu Ala Pro
    50                  55                  60                  
Arg Trp Ser Pro Ser Ala Trp Cys Trp Val Gly Gly Ala Leu Leu Gly
65                  70                  75                  80  
Pro Met Val Leu Ser Lys His Pro His Leu Cys Leu Val Ala Leu Cys
                85                  90                  95      
Glu Ala Glu Glu Ala Pro Pro Ala Ser Ser Thr Pro His Val Val Gly
            100                 105                 110         
Ser Arg Phe Asn Trp Lys Leu Phe Trp Gln Phe Leu His Pro His Leu
        115                 120                 125             
Leu Val Leu Gly Val Ala Val Val Leu Ala Leu Gly Ala Ala Leu Val
    130                 135                 140                 
Asn Val Gln Ile Pro Leu Leu Leu Gly Gln Leu Val Lys Val Val Ala
145                 150                 155                 160 
Lys Tyr Thr Arg Asp His Val Gly Ser Phe Met Thr Glu Ser Gln Asn
                165                 170                 175     
Leu Ser Thr His Leu Leu Ile Leu Tyr Gly Val Gln Gly Leu Leu Thr
            180                 185                 190         
Phe Gly Tyr Leu Val Leu Leu Ser His Val Gly Glu Arg Met Ala Val
        195                 200                 205             
Asp Met Arg Arg Ala Leu Phe Ser Ser Leu Leu Arg Gln Asn Ile Thr
    210                 215                 220                 
Phe Phe Asp Ala Asn Lys Thr Gly Gln Leu Val Ser Arg Leu Thr Thr
225                 230                 235                 240 
Asp Val Gln Glu Phe Lys Ser Ser Phe Lys Leu Val Ile Ser Gln Gly
                245                 250                 255     
Leu Arg Ser Cys Ser Gln Val Ala Gly Cys Leu Val Ser Leu Ser Met
            260                 265                 270         
Leu Ser Thr Arg Leu Thr Leu Leu Leu Met Val Ala Thr Pro Ala Leu
        275                 280                 285             
Met Gly Val Gly Thr Leu Met Gly Ser Gly Leu Arg Lys Leu Ser Arg
    290                 295                 300                 
Gln Cys Gln Glu His Ile Ala Arg Ala Met Gly Val Ala Asp Glu Ala
305                 310                 315                 320 
Leu Gly Asn Val Arg Thr Val Arg Ala Leu Ala Met Glu Gln Arg Glu
                325                 330                 335     
Glu Glu Arg Tyr Gly Ala Glu Leu Glu Ala Cys Arg Cys Arg Ala Glu
            340                 345                 350         
Glu Leu Gly Arg Gly Ile Ala Leu Phe Gln Gly Leu Ser Asn Ile Ala
        355                 360                 365             
Phe Asn Cys Met Val Leu Gly Thr Leu Phe Ile Gly Gly Ser Leu Val
    370                 375                 380                 
Ala Gly Gln Gln Leu Thr Gly Gly Asp Leu Met Ser Phe Leu Val Ala
385                 390                 395                 400 
Ser Gln Thr Val Gln Arg Ser Met Ala Asn Leu Ser Val Leu Phe Gly
                405                 410                 415     
Gln Val Val Arg Gly Leu Ser Ala Gly Ala Arg Val Phe Glu Tyr Met
            420                 425                 430         
Ala Leu Asn Pro Cys Ile Pro Leu Ser Gly Gly Cys Cys Val Pro Lys
        435                 440                 445             
Glu Gln Leu Arg Gly Ser Val Thr Phe Gln Asn Val Cys Phe Ser Tyr
    450                 455                 460                 
Pro Cys Arg Pro Gly Phe Glu Val Leu Lys Asp Phe Thr Leu Thr Leu
465                 470                 475                 480 
Pro Pro Gly Lys Ile Val Ala Leu Val Gly Gln Ser Gly Gly Gly Lys
                485                 490                 495     
Thr Thr Val Ala Ser Leu Leu Glu Arg Phe Tyr Asp Pro Thr Ala Gly
            500                 505                 510         
Val Val Met Leu Asp Gly Arg Asp Leu Arg Thr Leu Asp Pro Ser Trp
        515                 520                 525             
Leu Arg Gly Gln Val Val Gly Phe Ile Ser Gln Glu Pro Val Leu Phe
    530                 535                 540                 
Gly Thr Thr Ile Met Glu Asn Ile Arg Phe Gly Lys Leu Glu Ala Ser
545                 550                 555                 560 
Asp Glu Glu Val Tyr Thr Ala Ala Arg Glu Ala Asn Ala His Glu Phe
                565                 570                 575     
Ile Thr Ser Phe Pro Glu Gly Tyr Asn Thr Val Val Gly Glu Arg Gly
            580                 585                 590         
Thr Thr Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala
        595                 600                 605             
Leu Ile Lys Gln Pro Thr Val Leu Ile Leu Asp Glu Ala Thr Ser Ala
    610                 615                 620                 
Leu Asp Ala Glu Ser Glu Arg Val Val Gln Glu Ala Leu Asp Arg Ala
625                 630                 635                 640 
Ser Ala Gly Arg Thr Val Leu Val Ile Ala His Arg Leu Ser Thr Val
                645                 650                 655     
Arg Gly Ala His Cys Ile Val Val Met Ala Asp Gly Arg Val Trp Glu
            660                 665                 670         
Ala Gly Thr His Glu Glu Leu Leu Lys Lys Gly Gly Leu Tyr Ala Glu
        675                 680                 685             
Leu Ile Arg Arg Gln Ala Leu Asp Ala Pro Arg Thr Ala Ala Pro Pro
    690                 695                 700                 
Pro Lys Lys Pro Glu Gly Pro Arg Ser His Gln His Lys Ser
705                 710                 715             


<210> 5970
<211> 735
<212> PRT
<213> Homo sapiens

<400> 5970
Met Leu Val His Leu Phe Arg Val Gly Ile Arg Gly Gly Pro Phe Pro
 1               5                  10                  15      
Gly Arg Leu Leu Pro Pro Leu Arg Phe Gln Thr Phe Ser Ala Val Arg
            20                  25                  30          
Asn Thr Trp Arg Asn Gly Lys Thr Gly Gln Leu His Lys Ala Glu Gly
        35                  40                  45              
Glu Tyr Ser Asp Gly Tyr Arg Ser Ser Ser Leu Leu Arg Ala Val Ala
    50                  55                  60                  
His Leu Arg Ser Gln Leu Trp Ala His Leu Pro Arg Ala Pro Leu Ala
65                  70                  75                  80  
Pro Arg Trp Ser Pro Ser Ala Trp Cys Trp Val Gly Gly Ala Leu Leu
                85                  90                  95      
Gly Pro Met Val Leu Ser Lys His Pro His Leu Cys Leu Val Ala Leu
            100                 105                 110         
Cys Glu Ala Glu Glu Ala Pro Pro Ala Ser Ser Thr Pro His Val Val
        115                 120                 125             
Gly Ser Arg Phe Asn Trp Lys Leu Phe Trp Gln Phe Leu His Pro His
    130                 135                 140                 
Leu Leu Val Leu Gly Val Ala Val Val Leu Ala Leu Gly Ala Ala Leu
145                 150                 155                 160 
Val Asn Val Gln Ile Pro Leu Leu Leu Gly Gln Leu Val Lys Val Val
                165                 170                 175     
Ala Lys Tyr Thr Arg Asp His Val Gly Ser Phe Met Thr Glu Ser Gln
            180                 185                 190         
Asn Leu Ser Thr His Leu Leu Ile Leu Tyr Gly Val Gln Gly Leu Leu
        195                 200                 205             
Thr Phe Gly Tyr Leu Val Leu Leu Ser His Val Gly Glu Arg Met Ala
    210                 215                 220                 
Val Asp Met Arg Arg Ala Leu Phe Ser Ser Leu Leu Arg Gln Asn Ile
225                 230                 235                 240 
Thr Phe Phe Asp Ala Asn Lys Thr Gly Gln Leu Val Ser Arg Leu Thr
                245                 250                 255     
Thr Asp Val Gln Glu Phe Lys Ser Ser Phe Lys Leu Val Ile Ser Gln
            260                 265                 270         
Gly Leu Arg Ser Cys Ser Gln Val Ala Gly Cys Leu Val Ser Leu Ser
        275                 280                 285             
Met Leu Ser Thr Arg Leu Thr Leu Leu Leu Met Val Ala Thr Pro Ala
    290                 295                 300                 
Leu Met Gly Val Gly Thr Leu Met Gly Ser Gly Leu Arg Lys Leu Ser
305                 310                 315                 320 
Arg Gln Cys Gln Glu His Ile Ala Arg Ala Met Gly Val Ala Asp Glu
                325                 330                 335     
Ala Leu Gly Asn Val Arg Thr Val Arg Ala Leu Ala Met Glu Gln Arg
            340                 345                 350         
Glu Glu Glu Arg Tyr Gly Ala Glu Leu Glu Ala Cys Arg Cys Arg Ala
        355                 360                 365             
Glu Glu Leu Gly Arg Gly Ile Ala Leu Phe Gln Gly Leu Ser Asn Ile
    370                 375                 380                 
Ala Phe Asn Cys Met Val Leu Gly Thr Leu Phe Ile Gly Gly Ser Leu
385                 390                 395                 400 
Val Ala Gly Gln Gln Leu Thr Gly Gly Asp Leu Met Ser Phe Leu Val
                405                 410                 415     
Ala Ser Gln Thr Val Gln Arg Ser Met Ala Asn Leu Ser Val Leu Phe
            420                 425                 430         
Gly Gln Val Val Arg Gly Leu Ser Ala Gly Ala Arg Val Phe Glu Tyr
        435                 440                 445             
Met Ala Leu Asn Pro Cys Ile Pro Leu Ser Gly Gly Cys Cys Val Pro
    450                 455                 460                 
Lys Glu Gln Leu Arg Gly Ser Val Thr Phe Gln Asn Val Cys Phe Ser
465                 470                 475                 480 
Tyr Pro Cys Arg Pro Gly Phe Glu Val Leu Lys Asp Phe Thr Leu Thr
                485                 490                 495     
Leu Pro Pro Gly Lys Ile Val Ala Leu Val Gly Gln Ser Gly Gly Gly
            500                 505                 510         
Lys Thr Thr Val Ala Ser Leu Leu Glu Arg Phe Tyr Asp Pro Thr Ala
        515                 520                 525             
Gly Val Val Met Leu Asp Gly Arg Asp Leu Arg Thr Leu Asp Pro Ser
    530                 535                 540                 
Trp Leu Arg Gly Gln Val Val Gly Phe Ile Ser Gln Glu Pro Val Leu
545                 550                 555                 560 
Phe Gly Thr Thr Ile Met Glu Asn Ile Arg Phe Gly Lys Leu Glu Ala
                565                 570                 575     
Ser Asp Glu Glu Val Tyr Thr Ala Ala Arg Glu Ala Asn Ala His Glu
            580                 585                 590         
Phe Ile Thr Ser Phe Pro Glu Gly Tyr Asn Thr Val Val Gly Glu Arg
        595                 600                 605             
Gly Thr Thr Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg
    610                 615                 620                 
Ala Leu Ile Lys Gln Pro Thr Val Leu Ile Leu Asp Glu Ala Thr Ser
625                 630                 635                 640 
Ala Leu Asp Ala Glu Ser Glu Arg Val Val Gln Glu Ala Leu Asp Arg
                645                 650                 655     
Ala Ser Ala Gly Arg Thr Val Leu Val Ile Ala His Arg Leu Ser Thr
            660                 665                 670         
Val Arg Gly Ala His Cys Ile Val Val Met Ala Asp Gly Arg Val Trp
        675                 680                 685             
Glu Ala Gly Thr His Glu Glu Leu Leu Lys Lys Gly Gly Leu Tyr Ala
    690                 695                 700                 
Glu Leu Ile Arg Arg Gln Ala Leu Asp Ala Pro Arg Thr Ala Ala Pro
705                 710                 715                 720 
Pro Pro Lys Lys Pro Glu Gly Pro Arg Ser His Gln His Lys Ser
                725                 730                 735 


<210> 5971
<211> 701
<212> PRT
<213> Homo sapiens

<400> 5971
Met Leu Val His Leu Phe Arg Val Gly Ile Arg Gly Gly Pro Phe Pro
 1               5                  10                  15      
Gly Arg Leu Leu Pro Pro Leu Arg Phe Gln Thr Phe Ser Ala Val Arg
            20                  25                  30          
Tyr Ser Asp Gly Tyr Arg Ser Ser Ser Leu Leu Arg Ala Val Ala His
        35                  40                  45              
Leu Arg Ser Gln Leu Trp Ala His Leu Pro Arg Ala Leu Leu Gly Pro
    50                  55                  60                  
Met Val Leu Ser Lys His Pro His Leu Cys Leu Val Ala Leu Cys Glu
65                  70                  75                  80  
Ala Glu Glu Ala Pro Pro Ala Ser Ser Thr Pro His Val Val Gly Ser
                85                  90                  95      
Arg Phe Asn Trp Lys Leu Phe Trp Gln Phe Leu His Pro His Leu Leu
            100                 105                 110         
Val Leu Gly Val Ala Val Val Leu Ala Leu Gly Ala Ala Leu Val Asn
        115                 120                 125             
Val Gln Ile Pro Leu Leu Leu Gly Gln Leu Val Glu Val Val Ala Lys
    130                 135                 140                 
Tyr Thr Arg Asp His Val Gly Ser Phe Met Thr Glu Ser Gln Asn Leu
145                 150                 155                 160 
Ser Thr His Leu Leu Ile Leu Tyr Gly Val Gln Gly Leu Leu Thr Phe
                165                 170                 175     
Gly Tyr Leu Val Leu Leu Ser His Val Gly Glu Arg Met Ala Val Asp
            180                 185                 190         
Met Arg Arg Ala Leu Phe Ser Ser Leu Leu Arg Gln Asp Ile Thr Phe
        195                 200                 205             
Phe Asp Ala Asn Lys Thr Gly Gln Leu Val Ser Arg Leu Thr Thr Asp
    210                 215                 220                 
Val Gln Glu Phe Lys Ser Ser Phe Lys Leu Val Ile Ser Gln Gly Leu
225                 230                 235                 240 
Arg Ser Cys Thr Gln Val Ala Gly Cys Leu Val Ser Leu Ser Met Leu
                245                 250                 255     
Ser Thr Arg Leu Thr Leu Leu Leu Met Val Ala Thr Pro Ala Leu Met
            260                 265                 270         
Gly Val Gly Thr Leu Met Gly Ser Gly Leu Arg Lys Leu Ser Arg Gln
        275                 280                 285             
Cys Gln Glu Gln Ile Ala Arg Ala Met Gly Val Ala Asp Glu Ala Leu
    290                 295                 300                 
Gly Asn Val Arg Thr Val Arg Ala Phe Ala Met Glu Gln Arg Glu Glu
305                 310                 315                 320 
Glu Arg Tyr Gly Ala Glu Leu Glu Ala Cys Arg Cys Arg Ala Glu Glu
                325                 330                 335     
Leu Gly Arg Gly Ile Ala Leu Phe Gln Gly Leu Ser Asn Ile Ala Phe
            340                 345                 350         
Asn Cys Met Val Leu Gly Thr Leu Phe Thr Gly Gly Ser Leu Val Ala
        355                 360                 365             
Gly Gln Gln Leu Thr Gly Gly Asp Leu Met Ser Phe Leu Val Ala Ser
    370                 375                 380                 
Gln Thr Val Gln Arg Ser Met Ala Asn Leu Ser Val Leu Phe Gly Gln
385                 390                 395                 400 
Val Val Arg Gly Leu Ser Ala Gly Ala Arg Val Phe Glu Tyr Met Ala
                405                 410                 415     
Leu Asn Pro Cys Ile Pro Leu Ser Gly Gly Cys Cys Val Pro Lys Glu
            420                 425                 430         
Gln Leu Arg Gly Ser Val Thr Phe Gln Asn Val Cys Phe Ser Tyr Pro
        435                 440                 445             
Cys Arg Pro Gly Phe Glu Val Leu Lys Asp Phe Thr Leu Thr Leu Pro
    450                 455                 460                 
Pro Gly Lys Ile Val Ala Leu Val Gly Gln Ser Gly Gly Gly Lys Thr
465                 470                 475                 480 
Thr Val Ala Ser Leu Leu Glu Arg Phe Tyr Asp Pro Thr Ala Gly Val
                485                 490                 495     
Val Met Leu Asp Gly Arg Asp Leu Arg Thr Leu Asp Pro Ser Trp Leu
            500                 505                 510         
Arg Gly Gln Val Val Gly Phe Ile Ser Gln Glu Pro Val Leu Phe Gly
        515                 520                 525             
Thr Thr Ile Met Glu Asn Ile Arg Phe Gly Lys Leu Glu Ala Ser Asp
    530                 535                 540                 
Glu Glu Val Tyr Thr Ala Ala Arg Glu Ala Asn Ala His Glu Phe Ile
545                 550                 555                 560 
Thr Ser Phe Pro Glu Gly Tyr Asn Thr Val Val Gly Glu Arg Gly Thr
                565                 570                 575     
Thr Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu
            580                 585                 590         
Ile Lys Gln Pro Thr Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu
        595                 600                 605             
Asp Ala Glu Ser Glu Arg Val Val Gln Glu Ala Leu Asp Arg Ala Ser
    610                 615                 620                 
Ala Gly Arg Thr Val Leu Val Ile Ala His Arg Leu Ser Thr Val Arg
625                 630                 635                 640 
Gly Ala His Cys Ile Val Val Met Ala Asp Gly Arg Val Trp Glu Ala
                645                 650                 655     
Gly Thr His Glu Glu Leu Leu Lys Lys Gly Gly Leu Tyr Ala Glu Leu
            660                 665                 670         
Ile Arg Arg Gln Ala Leu Asp Ala Pro Arg Thr Ala Ala Pro Pro Pro
        675                 680                 685             
Lys Lys Pro Glu Gly Pro Arg Ser His Gln His Lys Ser
    690                 695                 700     


<210> 5972
<211> 265
<212> PRT
<213> Homo sapiens

<400> 5972
Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser
 1               5                  10                  15      
Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro
            20                  25                  30          
Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu
        35                  40                  45              
Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe
    50                  55                  60                  
His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn
65                  70                  75                  80  
Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn
                85                  90                  95      
Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr
            100                 105                 110         
Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His
        115                 120                 125             
Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys
    130                 135                 140                 
Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala
145                 150                 155                 160 
Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala
                165                 170                 175     
Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly
            180                 185                 190         
Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile
        195                 200                 205             
Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn
    210                 215                 220                 
Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys
225                 230                 235                 240 
Thr Tyr Lys Gln Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln
                245                 250                 255     
Leu Gly Ser Thr Tyr Phe Arg Glu Ala
            260                 265 


<210> 5973
<211> 1133
<212> PRT
<213> Homo sapiens

<400> 5973
Met Leu Arg Pro Gln Val Lys Glu Glu Ile Ile Cys Met Ile Gln Asn
 1               5                  10                  15      
Thr Phe Asn Phe Ser Leu Lys Gln Ser Lys His Leu Phe Gln Ile Leu
            20                  25                  30          
Met Glu Cys Met Val His Arg Asp Cys Ile Thr Ile Phe Asp Ala Asp
        35                  40                  45              
Ser Glu Glu Gln Gln Asp Leu Asp Leu Ala Ile Leu Thr Ala Leu Leu
    50                  55                  60                  
Lys Gly Thr Asn Leu Ser Ala Ser Glu Gln Leu Asn Leu Ala Met Ala
65                  70                  75                  80  
Trp Asp Arg Val Asp Ile Ala Lys Lys His Ile Leu Ile Tyr Glu Gln
                85                  90                  95      
His Trp Lys Pro Asp Ala Leu Glu Gln Ala Met Ser Asp Ala Leu Val
            100                 105                 110         
Met Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Tyr Gly Val Asn
        115                 120                 125             
Leu His Arg Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn Thr
    130                 135                 140                 
Lys Gln Gly Pro Thr Asn Thr Leu Leu His His Leu Val Gln Asp Val
145                 150                 155                 160 
Lys Gln His Thr Leu Leu Ser Gly Tyr Arg Ile Thr Leu Ile Asp Ile
                165                 170                 175     
Gly Leu Val Val Glu Tyr Leu Ile Gly Arg Ala Tyr Arg Ser Asn Tyr
            180                 185                 190         
Thr Arg Lys His Phe Arg Ala Leu Tyr Asn Asn Leu Tyr Arg Lys Tyr
        195                 200                 205             
Lys His Gln Arg His Ser Ser Gly Asn Arg Asn Glu Ser Ala Glu Ser
    210                 215                 220                 
Thr Leu His Ser Gln Phe Ile Arg Thr Ala Gln Pro Tyr Lys Phe Lys
225                 230                 235                 240 
Glu Lys Ser Ile Val Leu His Lys Ser Arg Lys Lys Ser Lys Glu Gln
                245                 250                 255     
Asn Val Ser Asp Asp Pro Glu Ser Thr Gly Phe Leu Tyr Pro Tyr Asn
            260                 265                 270         
Asp Leu Leu Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Met
        275                 280                 285             
Phe Phe Trp Gln His Gly Glu Glu Ala Thr Val Lys Ala Val Ile Ala
    290                 295                 300                 
Cys Ile Leu Tyr Arg Ala Met Ala His Glu Ala Lys Glu Ser His Met
305                 310                 315                 320 
Val Asp Asp Ala Ser Glu Glu Leu Lys Asn Tyr Ser Lys Gln Phe Gly
                325                 330                 335     
Gln Leu Ala Leu Asp Leu Leu Glu Lys Ala Phe Lys Gln Asn Glu Arg
            340                 345                 350         
Met Ala Met Thr Leu Leu Thr Tyr Glu Leu Arg Asn Trp Ser Asn Ser
        355                 360                 365             
Thr Cys Leu Lys Leu Ala Val Ser Gly Gly Leu Arg Pro Phe Val Ser
    370                 375                 380                 
His Thr Cys Thr Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu
385                 390                 395                 400 
Lys Met Arg Lys Asn Ser Trp Leu Lys Ile Ile Ile Ser Ile Ile Leu
                405                 410                 415     
Pro Pro Thr Ile Leu Thr Leu Glu Phe Lys Ser Lys Ala Glu Met Ser
            420                 425                 430         
His Val Pro Gln Ser Gln Asp Phe Gln Phe Met Trp Tyr Tyr Ser Asp
        435                 440                 445             
Gln Asn Ala Ser Ser Ser Lys Glu Ser Ala Ser Val Lys Glu Tyr Asp
    450                 455                 460                 
Leu Glu Arg Gly His Asp Glu Lys Leu Asp Glu Asn Gln His Phe Gly
465                 470                 475                 480 
Leu Glu Ser Gly His Gln His Leu Pro Trp Thr Arg Lys Val Tyr Glu
                485                 490                 495     
Phe Tyr Ser Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Met Ala Tyr
            500                 505                 510         
Leu Ala Phe Leu Met Leu Phe Thr Tyr Thr Val Leu Val Glu Met Gln
        515                 520                 525             
Pro Gln Pro Ser Val Gln Glu Trp Leu Val Ser Ile Tyr Ile Phe Thr
    530                 535                 540                 
Asn Ala Ile Glu Val Val Arg Glu Ile Cys Ile Ser Glu Pro Gly Lys
545                 550                 555                 560 
Phe Thr Gln Lys Val Lys Val Trp Ile Ser Glu Tyr Trp Asn Leu Thr
                565                 570                 575     
Glu Thr Val Ala Ile Gly Leu Phe Ser Ala Gly Phe Val Leu Arg Trp
            580                 585                 590         
Gly Asp Pro Pro Phe His Thr Ala Gly Arg Leu Ile Tyr Cys Ile Asp
        595                 600                 605             
Ile Ile Phe Trp Phe Ser Arg Leu Leu Asp Phe Phe Ala Val Asn Gln
    610                 615                 620                 
His Ala Gly Pro Tyr Val Thr Met Ile Ala Lys Met Thr Ala Asn Met
625                 630                 635                 640 
Phe Tyr Ile Val Ile Ile Met Ala Ile Val Leu Leu Ser Phe Gly Val
                645                 650                 655     
Ala Arg Lys Ala Ile Leu Ser Pro Lys Glu Pro Pro Ser Trp Ser Leu
            660                 665                 670         
Ala Arg Asp Ile Val Phe Glu Pro Tyr Trp Met Ile Tyr Gly Glu Val
        675                 680                 685             
Tyr Ala Gly Glu Ile Asp Val Cys Ser Ser Gln Pro Ser Cys Pro Pro
    690                 695                 700                 
Gly Ser Phe Leu Thr Pro Phe Leu Gln Ala Val Tyr Leu Phe Val Gln
705                 710                 715                 720 
Tyr Ile Ile Met Val Asn Leu Leu Ile Ala Phe Phe Asn Asn Val Tyr
                725                 730                 735     
Leu Asp Met Glu Ser Ile Ser Asn Asn Leu Trp Lys Tyr Asn Arg Tyr
            740                 745                 750         
Arg Tyr Ile Met Thr Tyr His Glu Lys Pro Trp Leu Pro Pro Pro Leu
        755                 760                 765             
Ile Leu Leu Ser His Val Gly Leu Leu Leu Arg Arg Leu Cys Cys His
    770                 775                 780                 
Arg Ala Pro His Asp Gln Glu Glu Gly Asp Val Gly Leu Lys Leu Tyr
785                 790                 795                 800 
Leu Ser Lys Glu Asp Leu Lys Lys Leu His Asp Phe Glu Glu Gln Cys
                805                 810                 815     
Val Glu Lys Tyr Phe His Glu Lys Met Glu Asp Val Asn Cys Ser Cys
            820                 825                 830         
Glu Glu Arg Ile Arg Val Thr Ser Glu Arg Val Thr Glu Met Tyr Phe
        835                 840                 845             
Gln Leu Lys Glu Met Asn Glu Lys Val Ser Phe Ile Lys Asp Ser Leu
    850                 855                 860                 
Leu Ser Leu Asp Ser Gln Val Gly His Leu Gln Asp Leu Ser Ala Leu
865                 870                 875                 880 
Thr Val Asp Thr Leu Lys Val Leu Ser Ala Val Asp Thr Leu Gln Glu
                885                 890                 895     
Asp Glu Ala Leu Leu Ala Lys Arg Lys His Ser Thr Cys Lys Lys Leu
            900                 905                 910         
Pro His Ser Trp Ser Asn Val Ile Cys Ala Glu Val Leu Gly Ser Met
        915                 920                 925             
Glu Ile Ala Gly Glu Lys Lys Tyr Gln Tyr Tyr Ser Met Pro Ser Ser
    930                 935                 940                 
Leu Leu Arg Ser Leu Ala Gly Gly Arg His Pro Pro Arg Val Gln Arg
945                 950                 955                 960 
Gly Ala Leu Leu Glu Ile Thr Asn Ser Lys Arg Glu Ala Thr Asn Val
                965                 970                 975     
Arg Asn Asp Gln Glu Arg Gln Glu Thr Gln Ser Ser Ile Val Val Ser
            980                 985                 990         
Gly Val Ser Pro Asn Arg Gln Ala His Ser Lys Tyr Gly Gln Phe Leu
        995                 1000                1005            
Leu Val Pro Ser Asn Leu Lys Arg Val Pro Phe Ser Ala Glu Thr Val
    1010                1015                1020                
Leu Pro Leu Ser Arg Pro Ser Val Pro Asp Val Leu Ala Thr Glu Gln
1025                1030                1035                1040
Asp Ile Gln Thr Glu Val Leu Val His Leu Thr Gly Gln Thr Pro Ile
                1045                1050                1055    
Val Ser Asp Trp Ala Ser Val Asp Glu Pro Lys Glu Lys His Glu Pro
            1060                1065                1070        
Ile Ala His Leu Leu Asp Gly Gln Asp Lys Ala Glu Gln Val Leu Pro
        1075                1080                1085            
Thr Leu Ser Cys Thr Pro Glu Pro Met Thr Met Ser Ser Pro Leu Arg
    1090                1095                1100                
Arg Tyr Arg Pro Phe Ala Arg Ser His Ser Phe Arg Phe His Lys Glu
1105                1110                1115                1120
Glu Lys Leu Met Lys Ile Cys Lys Ile Lys Ser Lys Glu
                1125                1130            


<210> 5974
<211> 2022
<212> PRT
<213> Homo sapiens

<400> 5974
Met Lys Glu Gln Pro Val Leu Glu Arg Leu Gln Ser Gln Lys Ser Trp
 1               5                  10                  15      
Ile Lys Gly Val Phe Asp Lys Arg Glu Cys Ser Thr Ile Ile Pro Ser
            20                  25                  30          
Ser Lys Asn Pro His Arg Cys Thr Pro Val Cys Gln Val Cys Gln Asn
        35                  40                  45              
Leu Ile Arg Cys Tyr Cys Gly Arg Leu Ile Gly Asp His Ala Gly Ile
    50                  55                  60                  
Asp Tyr Ser Trp Thr Ile Ser Ala Ala Lys Gly Lys Glu Ser Glu Gln
65                  70                  75                  80  
Trp Ser Val Glu Lys His Thr Thr Lys Ser Pro Thr Asp Thr Phe Gly
                85                  90                  95      
Thr Ile Asn Phe Gln Asp Gly Glu His Thr His His Ala Lys Tyr Ile
            100                 105                 110         
Arg Thr Ser Tyr Asp Thr Lys Leu Asp His Leu Leu His Leu Met Leu
        115                 120                 125             
Lys Glu Trp Lys Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly
    130                 135                 140                 
Gly Ile Gln Asn Phe Thr Met Pro Ser Lys Phe Lys Glu Ile Phe Ser
145                 150                 155                 160 
Gln Gly Leu Val Lys Ala Ala Glu Thr Thr Gly Ala Trp Ile Ile Thr
                165                 170                 175     
Glu Gly Ile Asn Thr Gly Val Ser Lys His Val Gly Asp Ala Leu Lys
            180                 185                 190         
Ser His Ser Ser His Ser Leu Arg Lys Ile Trp Thr Val Gly Ile Pro
        195                 200                 205             
Pro Trp Gly Val Ile Glu Asn Gln Arg Asp Leu Ile Gly Lys Asp Val
    210                 215                 220                 
Val Cys Leu Tyr Gln Thr Leu Asp Asn Pro Leu Ser Lys Leu Thr Thr
225                 230                 235                 240 
Leu Asn Ser Met His Ser His Phe Ile Leu Ser Asp Asp Gly Thr Val
                245                 250                 255     
Gly Lys Tyr Gly Asn Glu Met Lys Leu Arg Arg Asn Leu Glu Lys Tyr
            260                 265                 270         
Leu Ser Leu Gln Lys Ile His Cys Arg Ser Arg Gln Gly Val Pro Val
        275                 280                 285             
Val Gly Leu Val Val Glu Gly Gly Pro Asn Val Ile Leu Ser Val Trp
    290                 295                 300                 
Glu Thr Val Lys Asp Lys Asp Pro Val Val Val Cys Glu Gly Thr Gly
305                 310                 315                 320 
Arg Ala Ala Asp Leu Leu Ala Phe Thr His Lys His Leu Ala Asp Glu
                325                 330                 335     
Gly Met Leu Arg Pro Gln Val Lys Glu Glu Ile Ile Cys Met Ile Gln
            340                 345                 350         
Asn Thr Phe Asn Phe Ser Leu Lys Gln Ser Lys His Leu Phe Gln Ile
        355                 360                 365             
Leu Met Glu Cys Met Val His Arg Asp Cys Ile Thr Ile Phe Asp Ala
    370                 375                 380                 
Asp Ser Glu Glu Gln Gln Asp Leu Asp Leu Ala Ile Leu Thr Ala Leu
385                 390                 395                 400 
Leu Lys Gly Thr Asn Leu Ser Ala Ser Glu Gln Leu Asn Leu Ala Met
                405                 410                 415     
Ala Trp Asp Arg Val Asp Ile Ala Lys Lys His Ile Leu Ile Tyr Glu
            420                 425                 430         
Gln His Trp Lys Pro Asp Ala Leu Glu Gln Ala Met Ser Asp Ala Leu
        435                 440                 445             
Val Met Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Tyr Gly Val
    450                 455                 460                 
Asn Leu His Arg Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn
465                 470                 475                 480 
Thr Lys Gln Gly Pro Thr Asn Thr Leu Leu His His Leu Val Gln Asp
                485                 490                 495     
Val Lys Gln His Thr Leu Leu Ser Gly Tyr Arg Ile Thr Leu Ile Asp
            500                 505                 510         
Ile Gly Leu Val Val Glu Tyr Leu Ile Gly Arg Ala Tyr Arg Ser Asn
        515                 520                 525             
Tyr Thr Arg Lys His Phe Arg Ala Leu Tyr Asn Asn Leu Tyr Arg Lys
    530                 535                 540                 
Tyr Lys His Gln Arg His Ser Ser Gly Asn Arg Asn Glu Ser Ala Glu
545                 550                 555                 560 
Ser Thr Leu His Ser Gln Phe Ile Arg Thr Ala Gln Pro Tyr Lys Phe
                565                 570                 575     
Lys Glu Lys Ser Ile Val Leu His Lys Ser Arg Lys Lys Ser Lys Glu
            580                 585                 590         
Gln Asn Val Ser Asp Asp Pro Glu Ser Thr Gly Phe Leu Tyr Pro Tyr
        595                 600                 605             
Asn Asp Leu Leu Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala
    610                 615                 620                 
Met Phe Phe Trp Gln His Gly Glu Glu Ala Thr Val Lys Ala Val Ile
625                 630                 635                 640 
Ala Cys Ile Leu Tyr Arg Ala Met Ala His Glu Ala Lys Glu Ser His
                645                 650                 655     
Met Val Asp Asp Ala Ser Glu Glu Leu Lys Asn Tyr Ser Lys Gln Phe
            660                 665                 670         
Gly Gln Leu Ala Leu Asp Leu Leu Glu Lys Ala Phe Lys Gln Asn Glu
        675                 680                 685             
Arg Met Ala Met Thr Leu Leu Thr Tyr Glu Leu Arg Asn Trp Ser Asn
    690                 695                 700                 
Ser Thr Cys Leu Lys Leu Ala Val Ser Gly Gly Leu Arg Pro Phe Val
705                 710                 715                 720 
Ser His Thr Cys Thr Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg
                725                 730                 735     
Leu Lys Met Arg Lys Asn Ser Trp Leu Lys Ile Ile Ile Ser Ile Ile
            740                 745                 750         
Leu Pro Pro Thr Ile Leu Thr Leu Glu Phe Lys Ser Lys Ala Glu Met
        755                 760                 765             
Ser His Val Pro Gln Ser Gln Asp Phe Gln Phe Met Trp Tyr Tyr Ser
    770                 775                 780                 
Asp Gln Asn Ala Ser Ser Ser Lys Glu Ser Ala Ser Val Lys Glu Tyr
785                 790                 795                 800 
Asp Leu Glu Arg Gly His Asp Glu Lys Leu Asp Glu Asn Gln His Phe
                805                 810                 815     
Gly Leu Glu Ser Gly His Gln His Leu Pro Trp Thr Arg Lys Val Tyr
            820                 825                 830         
Glu Phe Tyr Ser Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Met Ala
        835                 840                 845             
Tyr Leu Ala Phe Leu Met Leu Phe Thr Tyr Thr Val Leu Val Glu Met
    850                 855                 860                 
Gln Pro Gln Pro Ser Val Gln Glu Trp Leu Val Ser Ile Tyr Ile Phe
865                 870                 875                 880 
Thr Asn Ala Ile Glu Val Val Arg Glu Ile Cys Ile Ser Glu Pro Gly
                885                 890                 895     
Lys Phe Thr Gln Lys Val Lys Val Trp Ile Ser Glu Tyr Trp Asn Leu
            900                 905                 910         
Thr Glu Thr Val Ala Ile Gly Leu Phe Ser Ala Gly Phe Val Leu Arg
        915                 920                 925             
Trp Gly Asp Pro Pro Phe His Thr Ala Gly Arg Leu Ile Tyr Cys Ile
    930                 935                 940                 
Asp Ile Ile Phe Trp Phe Ser Arg Leu Leu Asp Phe Phe Ala Val Asn
945                 950                 955                 960 
Gln His Ala Gly Pro Tyr Val Thr Met Ile Ala Lys Met Thr Ala Asn
                965                 970                 975     
Met Phe Tyr Ile Val Ile Ile Met Ala Ile Val Leu Leu Ser Phe Gly
            980                 985                 990         
Val Ala Arg Lys Ala Ile Leu Ser Pro Lys Glu Pro Pro Ser Trp Ser
        995                 1000                1005            
Leu Ala Arg Asp Ile Val Phe Glu Pro Tyr Trp Met Ile Tyr Gly Glu
    1010                1015                1020                
Val Tyr Ala Gly Glu Ile Asp Val Cys Ser Ser Gln Pro Ser Cys Pro
1025                1030                1035                1040
Pro Gly Ser Phe Leu Thr Pro Phe Leu Gln Ala Val Tyr Leu Phe Val
                1045                1050                1055    
Gln Tyr Ile Ile Met Val Asn Leu Leu Ile Ala Phe Phe Asn Asn Val
            1060                1065                1070        
Tyr Leu Asp Met Glu Ser Ile Ser Asn Asn Leu Trp Lys Tyr Asn Arg
        1075                1080                1085            
Tyr Arg Tyr Ile Met Thr Tyr His Glu Lys Pro Trp Leu Pro Pro Pro
    1090                1095                1100                
Leu Ile Leu Leu Ser His Val Gly Leu Leu Leu Arg Arg Leu Cys Cys
1105                1110                1115                1120
His Arg Ala Pro His Asp Gln Glu Glu Gly Asp Val Gly Leu Lys Leu
                1125                1130                1135    
Tyr Leu Ser Lys Glu Asp Leu Lys Lys Leu His Asp Phe Glu Glu Gln
            1140                1145                1150        
Cys Val Glu Lys Tyr Phe His Glu Lys Met Glu Asp Val Asn Cys Ser
        1155                1160                1165            
Cys Glu Glu Arg Ile Arg Val Thr Ser Glu Arg Val Thr Glu Met Tyr
    1170                1175                1180                
Phe Gln Leu Lys Glu Met Asn Glu Lys Val Ser Phe Ile Lys Asp Ser
1185                1190                1195                1200
Leu Leu Ser Leu Asp Ser Gln Val Gly His Leu Gln Asp Leu Ser Ala
                1205                1210                1215    
Leu Thr Val Asp Thr Leu Lys Val Leu Ser Ala Val Asp Thr Leu Gln
            1220                1225                1230        
Glu Asp Glu Ala Leu Leu Ala Lys Arg Lys His Ser Thr Cys Lys Lys
        1235                1240                1245            
Leu Pro His Ser Trp Ser Asn Val Ile Cys Ala Glu Val Leu Gly Ser
    1250                1255                1260                
Met Glu Ile Ala Gly Glu Lys Lys Tyr Gln Tyr Tyr Ser Met Pro Ser
1265                1270                1275                1280
Ser Leu Leu Arg Ser Leu Ala Gly Gly Arg His Pro Pro Arg Val Gln
                1285                1290                1295    
Arg Gly Ala Leu Leu Glu Ile Thr Asn Ser Lys Arg Glu Ala Thr Asn
            1300                1305                1310        
Val Arg Asn Asp Gln Glu Arg Gln Glu Thr Gln Ser Ser Ile Val Val
        1315                1320                1325            
Ser Gly Val Ser Pro Asn Arg Gln Ala His Ser Lys Tyr Gly Gln Phe
    1330                1335                1340                
Leu Leu Val Pro Ser Asn Leu Lys Arg Val Pro Phe Ser Ala Glu Thr
1345                1350                1355                1360
Val Leu Pro Leu Ser Arg Pro Ser Val Pro Asp Val Leu Ala Thr Glu
                1365                1370                1375    
Gln Asp Ile Gln Thr Glu Val Leu Val His Leu Thr Gly Gln Thr Pro
            1380                1385                1390        
Val Val Ser Asp Trp Ala Ser Val Asp Glu Pro Lys Glu Lys His Glu
        1395                1400                1405            
Pro Ile Ala His Leu Leu Asp Gly Gln Asp Lys Ala Glu Gln Val Leu
    1410                1415                1420                
Pro Thr Leu Ser Cys Thr Pro Glu Pro Met Thr Met Ser Ser Pro Leu
1425                1430                1435                1440
Ser Gln Ala Lys Ile Met Gln Thr Gly Gly Gly Tyr Val Asn Trp Ala
                1445                1450                1455    
Phe Ser Glu Gly Asp Glu Thr Gly Val Phe Ser Ile Lys Lys Lys Trp
            1460                1465                1470        
Gln Thr Cys Leu Pro Ser Thr Cys Asp Ser Asp Ser Ser Arg Ser Glu
        1475                1480                1485            
Gln His Gln Lys Gln Ala Gln Asp Ser Ser Leu Ser Asp Asn Ser Thr
    1490                1495                1500                
Arg Ser Ala Gln Ser Ser Glu Cys Ser Glu Val Gly Pro Trp Leu Gln
1505                1510                1515                1520
Pro Asn Thr Ser Phe Trp Ile Asn Pro Leu Arg Arg Tyr Arg Pro Phe
                1525                1530                1535    
Ala Arg Ser His Ser Phe Arg Phe His Lys Glu Glu Lys Leu Met Lys
            1540                1545                1550        
Ile Cys Lys Ile Lys Asn Leu Ser Gly Ser Ser Glu Ile Gly Gln Gly
        1555                1560                1565            
Ala Trp Val Lys Ala Lys Met Leu Thr Lys Asp Arg Arg Leu Ser Lys
    1570                1575                1580                
Lys Lys Lys Asn Thr Gln Gly Leu Gln Val Pro Ile Ile Thr Val Asn
1585                1590                1595                1600
Ala Cys Ser Gln Ser Asp Gln Leu Asn Pro Glu Pro Gly Glu Asn Ser
                1605                1610                1615    
Ile Ser Glu Glu Glu Tyr Ser Lys Asn Trp Phe Thr Val Ser Lys Phe
            1620                1625                1630        
Ser His Thr Gly Val Glu Pro Tyr Ile His Gln Lys Met Lys Thr Lys
        1635                1640                1645            
Glu Ile Gly Gln Cys Ala Ile Gln Ile Ser Asp Tyr Leu Lys Gln Ser
    1650                1655                1660                
Gln Glu Asp Leu Ser Lys Asn Ser Leu Trp Asn Ser Arg Ser Thr Asn
1665                1670                1675                1680
Leu Asn Arg Asn Ser Leu Leu Lys Ser Ser Ile Gly Val Asp Lys Ile
                1685                1690                1695    
Ser Ala Ser Leu Lys Ser Pro Gln Glu Pro His His His Tyr Ser Ala
            1700                1705                1710        
Ile Glu Arg Asn Asn Leu Met Arg Leu Ser Gln Thr Ile Pro Phe Thr
        1715                1720                1725            
Pro Val Gln Leu Phe Ala Gly Glu Glu Ile Thr Val Tyr Arg Leu Glu
    1730                1735                1740                
Glu Ser Ser Pro Leu Asn Leu Asp Lys Ser Met Ser Ser Trp Ser Gln
1745                1750                1755                1760
Arg Gly Arg Ala Ala Met Ile Gln Val Leu Ser Arg Glu Glu Met Asp
                1765                1770                1775    
Gly Gly Leu Arg Lys Ala Met Arg Val Val Ser Thr Trp Ser Glu Asp
            1780                1785                1790        
Asp Ile Leu Lys Pro Gly Gln Val Phe Ile Val Lys Ser Phe Leu Pro
        1795                1800                1805            
Glu Val Val Arg Thr Trp His Lys Ile Phe Gln Glu Ser Thr Val Leu
    1810                1815                1820                
His Leu Cys Leu Arg Glu Ile Gln Gln Gln Arg Ala Ala Gln Lys Leu
1825                1830                1835                1840
Ile Tyr Thr Phe Asn Gln Val Lys Pro Gln Thr Ile Pro Tyr Thr Pro
                1845                1850                1855    
Arg Phe Leu Glu Val Phe Leu Ile Tyr Cys His Ser Ala Asn Gln Trp
            1860                1865                1870        
Leu Thr Ile Glu Lys Tyr Met Thr Gly Glu Phe Arg Lys Tyr Asn Asn
        1875                1880                1885            
Asn Asn Gly Asp Glu Ile Thr Pro Thr Asn Thr Leu Glu Glu Leu Met
    1890                1895                1900                
Leu Ala Phe Ser His Trp Thr Tyr Glu Tyr Thr Arg Gly Glu Leu Leu
1905                1910                1915                1920
Val Leu Asp Leu Gln Gly Val Gly Glu Asn Leu Thr Asp Pro Ser Val
                1925                1930                1935    
Ile Lys Pro Glu Val Lys Gln Ser Arg Gly Met Val Phe Gly Pro Ala
            1940                1945                1950        
Asn Leu Gly Glu Asp Ala Ile Arg Asn Phe Ile Ala Lys His His Cys
        1955                1960                1965            
Asn Ser Cys Cys Arg Lys Leu Lys Leu Pro Asp Leu Lys Arg Asn Asp
    1970                1975                1980                
Tyr Ser Pro Glu Arg Ile Asn Ser Thr Phe Gly Leu Glu Ile Lys Ile
1985                1990                1995                2000
Glu Ser Ala Glu Glu Pro Pro Ala Arg Glu Thr Gly Arg Asn Ser Pro
                2005                2010                2015    
Glu Asp Asp Met Gln Leu
            2020        


<210> 5975
<211> 479
<212> PRT
<213> Homo sapiens

<400> 5975
Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val
 1               5                  10                  15      
Arg Leu Val Thr Ser Ser Ser His Asn Arg Tyr Glu Thr Val Glu Met
            20                  25                  30          
Val Phe Ile Ala Thr Val Thr Gly Ser Leu Ser Leu Val Thr Val Val
        35                  40                  45              
Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln
    50                  55                  60                  
Thr Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile
65                  70                  75                  80  
Ile Gly Ala Phe Ser Met Asn Leu Tyr Thr Val Tyr Ile Ile Lys Gly
                85                  90                  95      
Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp
            100                 105                 110         
Tyr Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe
        115                 120                 125             
Asp Arg Tyr Phe Cys Val Thr Lys Pro Leu Thr Tyr Pro Ala Arg Arg
    130                 135                 140                 
Thr Thr Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser
145                 150                 155                 160 
Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly
                165                 170                 175     
Lys Arg Thr Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn
            180                 185                 190         
Pro Ala Val Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Leu Pro Val
        195                 200                 205             
Val Ile Met Thr Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser
    210                 215                 220                 
Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys
225                 230                 235                 240 
Thr Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys
                245                 250                 255     
Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu
            260                 265                 270         
Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala
        275                 280                 285             
Asp Lys Asp Thr Ser Asn Glu Ser Ser Ser Gly Ser Ala Thr Gln Asn
    290                 295                 300                 
Thr Lys Glu Arg Pro Ala Thr Glu Leu Ser Thr Thr Glu Ala Thr Thr
305                 310                 315                 320 
Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala
                325                 330                 335     
Ser Arg Trp Ser Lys Ile Gln Ile Val Thr Lys Gln Thr Gly Asn Glu
            340                 345                 350         
Cys Val Thr Ala Ile Glu Ile Val Pro Ala Thr Pro Ala Gly Met Arg
        355                 360                 365             
Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln
    370                 375                 380                 
Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Thr Arg
385                 390                 395                 400 
Thr Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr
                405                 410                 415     
Asn Val Met Val Leu Val Asn Thr Phe Cys Gln Ser Cys Ile Pro Asp
            420                 425                 430         
Thr Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile
        435                 440                 445             
Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys Lys Thr Phe
    450                 455                 460                 
Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Thr Ala Arg
465                 470                 475                 


<210> 5976
<211> 211
<212> PRT
<213> Homo sapiens

<400> 5976
Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu
 1               5                  10                  15      
Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile
            20                  25                  30          
Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu
        35                  40                  45              
Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys
    50                  55                  60                  
Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr
65                  70                  75                  80  
Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe
                85                  90                  95      
Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu
            100                 105                 110         
Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu
        115                 120                 125             
Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile
    130                 135                 140                 
Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu
145                 150                 155                 160 
Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu
                165                 170                 175     
Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser
            180                 185                 190         
Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys
        195                 200                 205             
Asp Tyr Val
    210     


<210> 5977
<211> 385
<212> PRT
<213> Homo sapiens

<400> 5977
Met Ala Glu Gln Thr Tyr Ser Trp Ala Tyr Ser Leu Val Asp Ser Ser
 1               5                  10                  15      
Gln Val Ser Thr Phe Leu Ile Ser Ile Leu Leu Ile Val Tyr Gly Ser
            20                  25                  30          
Phe Arg Ser Leu Asn Met Asp Phe Glu Asn Gln Asp Lys Glu Lys Asp
        35                  40                  45              
Ser Asn Ser Ser Ser Gly Ser Phe Asn Gly Glu Gln Glu Pro Ile Ile
    50                  55                  60                  
Gly Phe Gln Pro Met Asp Ser Thr Arg Ala Arg Phe Leu Pro Met Gly
65                  70                  75                  80  
Ala Cys Val Ser Leu Leu Val Met Phe Phe Phe Phe Asp Ser Val Gln
                85                  90                  95      
Val Val Phe Thr Ile Cys Thr Ala Val Leu Ala Thr Ile Ala Phe Ala
            100                 105                 110         
Phe Leu Leu Leu Pro Met Cys Gln Tyr Leu Thr Arg Pro Cys Ser Pro
        115                 120                 125             
Gln Asn Lys Ile Ser Phe Gly Cys Cys Gly Arg Phe Thr Ala Ala Glu
    130                 135                 140                 
Leu Leu Ser Phe Ser Leu Ser Val Met Leu Val Leu Ile Trp Val Leu
145                 150                 155                 160 
Thr Gly His Trp Leu Leu Met Asp Ala Leu Ala Met Gly Leu Cys Val
                165                 170                 175     
Ala Met Ile Ala Phe Val Arg Leu Pro Ser Leu Lys Val Ser Cys Leu
            180                 185                 190         
Leu Leu Ser Gly Leu Leu Ile Tyr Asp Val Phe Trp Val Phe Phe Ser
        195                 200                 205             
Ala Tyr Ile Phe Asn Ser Asn Val Met Val Lys Val Ala Thr Gln Pro
    210                 215                 220                 
Ala Asp Asn Pro Leu Asp Val Leu Ser Arg Lys Leu His Leu Gly Pro
225                 230                 235                 240 
Asn Val Gly Arg Asp Val Pro Arg Leu Ser Leu Pro Gly Lys Leu Val
                245                 250                 255     
Phe Pro Ser Ser Thr Gly Ser His Phe Ser Met Leu Gly Ile Gly Asp
            260                 265                 270         
Ile Val Met Pro Gly Leu Leu Leu Cys Phe Val Leu Arg Tyr Asp Asn
        275                 280                 285             
Tyr Lys Lys Gln Ala Ser Gly Asp Ser Cys Gly Ala Pro Gly Pro Ala
    290                 295                 300                 
Asn Ile Ser Gly Arg Met Gln Lys Val Ser Tyr Phe His Cys Thr Leu
305                 310                 315                 320 
Ile Gly Tyr Phe Val Gly Leu Leu Thr Ala Thr Val Ala Ser Arg Ile
                325                 330                 335     
His Arg Ala Ala Gln Pro Ala Leu Leu Tyr Leu Val Pro Phe Thr Leu
            340                 345                 350         
Leu Pro Leu Leu Thr Met Ala Tyr Leu Lys Gly Asp Leu Arg Arg Met
        355                 360                 365             
Trp Ser Glu Pro Phe His Ser Lys Ser Ser Ser Ser Arg Phe Leu Glu
    370                 375                 380                 
Val
385 


<210> 5978
<211> 1732
<212> PRT
<213> Homo sapiens

<400> 5978
Met Phe Phe Lys Gly Gly Ser Trp Leu Trp Leu Tyr Ile Arg Thr Ser
 1               5                  10                  15      
Ile Ile Leu Gly Ser Glu Leu Asn Ser Pro Ala Pro His Gly Gln Asn
            20                  25                  30          
Asn Cys Tyr Gln Leu Asn Arg Phe Gln Cys Ser Phe Glu Glu Ala Gln
        35                  40                  45              
His Tyr Cys His Val Gln Arg Gly Phe Leu Ala His Ile Trp Asn Lys
    50                  55                  60                  
Glu Val Gln Asp Leu Ile Arg Asp Tyr Leu Glu Glu Gly Lys Lys Trp
65                  70                  75                  80  
Trp Ile Gly Gln Asn Val Met Pro Leu Lys Lys His Gln Asp Asn Lys
                85                  90                  95      
Tyr Pro Ala Asp Val Ala Ala Asn Gly Pro Pro Lys Pro Leu Ser Cys
            100                 105                 110         
Thr Tyr Leu Ser Arg Asn Phe Ile Arg Ile Ser Ser Lys Gly Asp Lys
        115                 120                 125             
Cys Leu Leu Lys Tyr Tyr Phe Ile Cys Gln Thr Gly Asp Phe Leu Asp
    130                 135                 140                 
Gly Asp Ala His Tyr Glu Arg Asn Gly Asn Asn Ser His Leu Tyr Gln
145                 150                 155                 160 
Arg His Lys Lys Thr Lys Arg Gly Val Ala Ile Ala Arg Asp Lys Met
                165                 170                 175     
Pro Pro Gly Pro Gly His Leu Pro Thr Thr Cys His Tyr Pro Leu Pro
            180                 185                 190         
Ala His Leu Ser Lys Thr Leu Cys His Pro Ile Ser Gln Phe Pro Ser
        195                 200                 205             
Val Leu Ser Ser Ile Thr Ser Gln Val Thr Ser Ala Ala Ser Glu Pro
    210                 215                 220                 
Ser Ser Gln Pro Leu Pro Val Ile Thr Gln Leu Thr Met Pro Val Ser
225                 230                 235                 240 
Val Thr His Ala Gly Gln Ser Leu Ala Glu Thr Thr Ser Ser Pro Lys
                245                 250                 255     
Glu Glu Gly His Pro Asn Thr Phe Thr Ser Tyr Leu Gln Val Ser Leu
            260                 265                 270         
Gln Lys Ala Ser Gly Gln Val Ile Asp Glu Ile Ala Gly Asn Phe Ser
        275                 280                 285             
Arg Ala Val His Gly Leu Gln Ala Leu Asn Lys Leu Gln Glu Ala Cys
    290                 295                 300                 
Glu Phe Leu Gln Lys Leu Thr Ala Leu Thr Pro Arg Phe Ser Lys Pro
305                 310                 315                 320 
Ala Gln Val Asn Leu Ile Asn Ser Leu Ile Tyr Leu Ser Glu Glu Leu
                325                 330                 335     
Leu Arg Ile Pro Phe Gln Asn Asn Asn Ser Leu Gly Phe Lys Val Pro
            340                 345                 350         
Pro Thr Val Cys Pro Phe His Ser Leu Asn Asn Val Thr Lys Ala Gly
        355                 360                 365             
Glu Gly Ser Trp Leu Glu Ser Lys Arg His Thr Glu Pro Val Glu Asp
    370                 375                 380                 
Ile Leu Glu Met Ser Leu Val Glu Phe Gly Asn Ile Gly Glu Ala Phe
385                 390                 395                 400 
Leu Glu Gln Asn Gln Ser Pro Glu Ser Ser Val Thr Leu Thr Ser Ala
                405                 410                 415     
Asn Ala Thr Leu Leu Leu Ser Arg Gln Asn Ile Ser Thr Leu Pro Leu
            420                 425                 430         
Ser Ser Tyr Thr Leu Gly His Pro Ala Pro Val Arg Leu Gly Phe Pro
        435                 440                 445             
Ser Ala Leu Ala Leu Lys Glu Leu Leu Asn Lys His Pro Gly Val Asn
    450                 455                 460                 
Val Gln Ile Thr Gly Leu Ala Phe Asn Pro Phe Lys Asp Leu Asp Asn
465                 470                 475                 480 
Arg Asn Ile Val Gly Ser Ile Gly Ser Val Leu Leu Ser Ala Asn Arg
                485                 490                 495     
Lys Leu Leu Gln Val His Asp Leu Met Glu Asp Ile Glu Ile Met Leu
            500                 505                 510         
Trp Arg Asn Val Ser Leu Glu Thr His Pro Thr Ser Leu Asn Met Ser
        515                 520                 525             
Thr His Gln Leu Thr Ile Thr Val Asn Val Thr Ser Leu Glu Lys Ser
    530                 535                 540                 
Leu Ile Val Ser Ile Asp Pro Asp Ser Pro Leu Leu Met Thr Leu Tyr
545                 550                 555                 560 
Leu Gly Phe Gln Tyr Gln Pro Asn Cys Thr His Phe His Leu Asn Ile
                565                 570                 575     
Thr Leu Pro Lys Asp Lys Val Trp Gln Lys Asp Glu Glu Tyr Thr Trp
            580                 585                 590         
Val Leu Asn Pro Glu His Leu Gln His Gly Ile Gly Thr Tyr Tyr Ile
        595                 600                 605             
Thr Ala Val Leu Ser Glu Arg Gln Glu Gly Ala Gln Gln Thr Pro Ser
    610                 615                 620                 
Leu Val Ser Val Ile Thr Ala Val Thr Gln Cys Tyr Tyr Trp Glu Ile
625                 630                 635                 640 
His Asn Gln Thr Trp Ser Ser Ala Gly Cys Gln Val Gly Pro Gln Ser
                645                 650                 655     
Thr Ile Leu Arg Thr Gln Cys Leu Cys Asn His Leu Thr Phe Phe Ala
            660                 665                 670         
Ser Asp Phe Phe Val Val Pro Arg Thr Val Asn Val Glu Asp Thr Ile
        675                 680                 685             
Lys Leu Phe Leu Arg Val Thr Asn Asn Pro Val Gly Val Ser Leu Leu
    690                 695                 700                 
Ala Ser Leu Leu Gly Phe Tyr Val Ile Thr Val Val Trp Ala Arg Lys
705                 710                 715                 720 
Lys Asp Gln Ala Asp Met Gln Lys Val Lys Val Thr Val Leu Ala Asp
                725                 730                 735     
Asn Asp Pro Ser Ala Gln Phe His Tyr Leu Ile Gln Val Tyr Thr Gly
            740                 745                 750         
Tyr Arg Arg Ser Ala Ala Thr Thr Ala Lys Val Val Ile Thr Leu Tyr
        755                 760                 765             
Gly Ser Glu Gly Arg Ser Glu Pro His His Leu Cys Asp Pro Gln Lys
    770                 775                 780                 
Thr Val Phe Glu Arg Gly Gly Leu Asp Val Phe Leu Leu Thr Thr Trp
785                 790                 795                 800 
Thr Ser Leu Gly Asn Leu His Ser Leu Arg Leu Trp His Asp Asn Ser
                805                 810                 815     
Gly Val Ser Pro Ser Trp Tyr Val Ser Gln Val Ile Val Cys Asp Met
            820                 825                 830         
Ala Val Lys Arg Lys Trp His Phe Leu Cys Asn Cys Trp Leu Ala Val
        835                 840                 845             
Asp Leu Gly Asp Cys Glu Leu Asp Arg Val Phe Ile Pro Val Ser Lys
    850                 855                 860                 
Arg Glu Leu Phe Ser Phe Arg His Leu Phe Ser Ser Met Ile Val Glu
865                 870                 875                 880 
Lys Phe Thr Gln Asp Tyr Leu Trp Leu Ser Ile Ala Thr Arg His Pro
                885                 890                 895     
Trp Asn Gln Phe Thr Arg Val Gln Arg Leu Ser Cys Cys Met Thr Leu
            900                 905                 910         
Leu Leu Cys Asn Met Val Ile Asn Val Met Phe Trp Lys Ile Asn Ser
        915                 920                 925             
Thr Thr Ala Lys Arg Asp Glu Gln Met Arg Pro Phe Ala Val Ala Trp
    930                 935                 940                 
Ser Glu Leu Leu Val Ser Ile His Thr Ala Val Ile Leu Phe Pro Ile
945                 950                 955                 960 
Asn Leu Val Ile Gly Arg Leu Phe Pro Leu Ile Glu Pro Gln Glu Thr
                965                 970                 975     
Leu Pro Leu Phe Pro Pro Ile Gln Ala Ser Cys Leu Ser Asp Ala Ser
            980                 985                 990         
Val Glu Pro Leu Ser Ala Thr Met Val Val Glu Glu Leu Lys Glu Thr
        995                 1000                1005            
Val Arg Phe Leu Leu Arg Arg Asn Thr Tyr Leu Leu Ser Lys Cys Glu
    1010                1015                1020                
Gln Pro Pro Trp Ser Ser Trp Asp Ile Thr Lys Leu Val Lys Leu Leu
1025                1030                1035                1040
Ser Ser Leu Val Ser Ser His Leu Glu Gly Gln Gly Cys His Gln Gln
                1045                1050                1055    
Gly Glu Arg His Trp Ala Arg Val Val Pro Glu Asn His His His Phe
            1060                1065                1070        
Cys Cys Tyr Leu His Arg Val Leu Gln Arg Leu Lys Ser His Leu Gly
        1075                1080                1085            
Thr Leu Gly Leu Thr Gln Gly His Gln Ser Cys Asp Phe Leu Asp Ala
    1090                1095                1100                
Ala Ser Gln Leu Gln Lys Leu Gln Glu Leu Leu Glu Thr His Ile Leu
1105                1110                1115                1120
Pro Thr Glu Gln Glu Pro Ser Arg Glu Val Thr Ser Phe Ala Ile Leu
                1125                1130                1135    
Ser Ser Glu Glu Gly Lys Lys Pro Ile Ser Asn Gly Leu Ser Lys Trp
            1140                1145                1150        
Leu Thr Ser Val Cys Trp Leu Leu Leu Gly Phe Thr Ser Leu Ala Ser
        1155                1160                1165            
Ala Phe Phe Thr Ala Leu Tyr Ser Leu Glu Leu Ser Lys Asp Gln Ala
    1170                1175                1180                
Thr Ser Trp Met Ile Ser Ile Ile Leu Ser Val Leu Gln Asn Ile Phe
1185                1190                1195                1200
Ile Ser Gln Pro Val Lys Val Val Phe Phe Thr Phe Leu Tyr Ser Leu
                1205                1210                1215    
Met Met Ser Arg Met Pro Arg Leu Asn Lys Glu Asn Glu Gln Gln Thr
            1220                1225                1230        
Lys Arg Ile Leu Ala Leu Leu Ala Lys Cys Ser Ser Ser Val Pro Gly
        1235                1240                1245            
Ser Arg Asp Lys Asn Asn Pro Val Tyr Val Ala Pro Ala Ile Asn Ser
    1250                1255                1260                
Pro Thr Lys His Pro Glu Arg Thr Leu Lys Lys Lys Lys Leu Phe Lys
1265                1270                1275                1280
Leu Thr Gly Asp Ile Leu Val Gln Ile Leu Phe Leu Thr Leu Leu Met
                1285                1290                1295    
Thr Ala Ile Tyr Ser Ala Lys Asn Ser Asn Arg Phe Tyr Leu His Gln
            1300                1305                1310        
Ala Ile Trp Lys Thr Phe Ser His Gln Phe Ser Glu Ile Lys Leu Leu
        1315                1320                1325            
Gln Asp Phe Tyr Pro Trp Ala Asn His Ile Leu Leu Pro Ser Leu Tyr
    1330                1335                1340                
Gly Asp Tyr Arg Gly Lys Asn Ala Val Leu Glu Pro Ser His Cys Lys
1345                1350                1355                1360
Cys Gly Val Gln Leu Ile Phe Gln Ile Pro Arg Thr Lys Thr Tyr Glu
                1365                1370                1375    
Lys Val Asp Glu Gly Gln Leu Ala Phe Cys Asp Asn Gly His Thr Cys
            1380                1385                1390        
Gly Arg Pro Lys Ser Leu Phe Pro Gly Leu His Leu Arg Arg Phe Ser
        1395                1400                1405            
Tyr Ile Cys Ser Pro Arg Pro Met Val Leu Ile Pro Thr Asp Glu Leu
    1410                1415                1420                
His Glu Arg Leu Thr Ser Lys Asn Glu Asn Gly Phe Ser Tyr Ile Met
1425                1430                1435                1440
Arg Gly Ala Phe Phe Thr Ser Leu Arg Leu Glu Ser Phe Thr Ser Leu
                1445                1450                1455    
Gln Met Ser Lys Lys Gly Cys Val Trp Ser Ile Ile Ser Gln Val Ile
            1460                1465                1470        
Tyr Tyr Leu Leu Val Cys Tyr Tyr Ala Phe Ile Gln Gly Cys Gln Leu
        1475                1480                1485            
Lys Gln Gln Lys Trp Arg Phe Phe Thr Gly Lys Arg Asn Ile Leu Asp
    1490                1495                1500                
Thr Ser Ile Ile Leu Ile Ser Phe Ile Leu Leu Gly Leu Asp Met Lys
1505                1510                1515                1520
Ser Ile Ser Leu His Lys Lys Asn Met Ala Arg Tyr Arg Asp Asp Gln
                1525                1530                1535    
Asp Arg Phe Ile Ser Phe Tyr Glu Ala Val Lys Val Asn Ser Ala Ala
            1540                1545                1550        
Thr His Leu Val Gly Phe Pro Val Leu Leu Ala Thr Val Gln Leu Trp
        1555                1560                1565            
Asn Leu Leu Arg His Ser Pro Arg Leu Arg Val Ile Ser Arg Thr Leu
    1570                1575                1580                
Ser Arg Ala Trp Asp Glu Val Val Gly Phe Leu Leu Ile Ile Leu Ile
1585                1590                1595                1600
Leu Leu Thr Gly Tyr Ala Ile Ala Phe Asn Leu Leu Phe Gly Cys Ser
                1605                1610                1615    
Ile Ser Asp Tyr Arg Thr Phe Phe Ser Ser Ala Val Thr Val Val Gly
            1620                1625                1630        
Leu Leu Met Gly Ile Ser His Gln Glu Glu Val Phe Ala Leu Asp Pro
        1635                1640                1645            
Val Leu Gly Thr Phe Leu Ile Leu Thr Ser Val Ile Leu Met Val Leu
    1650                1655                1660                
Val Val Ile Asn Leu Phe Val Ser Ala Ile Leu Met Ala Phe Gly Lys
1665                1670                1675                1680
Glu Arg Lys Ser Leu Lys Lys Glu Ala Ala Leu Ile Asp Thr Leu Leu
                1685                1690                1695    
Gln Lys Leu Ser Asn Leu Leu Gly Ile Ser Trp Pro Gln Lys Thr Ser
            1700                1705                1710        
Ser Glu Gln Ala Ala Thr Thr Ala Val Gly Ser Asp Thr Glu Val Leu
        1715                1720                1725            
Asp Glu Leu Pro
    1730        


<210> 5979
<211> 475
<212> PRT
<213> Homo sapiens

<400> 5979
Met Ala Val Val Ser Glu Asp Asp Phe Gln His Ser Ser Asn Ser Thr
 1               5                  10                  15      
Tyr Arg Thr Thr Ser Ser Ser Leu Arg Ala Asp Gln Glu Ala Leu Leu
            20                  25                  30          
Glu Lys Leu Leu Asp Arg Pro Pro Pro Gly Leu Gln Arg Pro Glu Asp
        35                  40                  45              
Arg Phe Cys Gly Thr Tyr Ile Ile Phe Phe Ser Leu Gly Ile Gly Ser
    50                  55                  60                  
Leu Leu Pro Trp Asn Phe Phe Ile Thr Ala Lys Glu Tyr Trp Met Phe
65                  70                  75                  80  
Lys Leu Arg Asn Ser Ser Ser Pro Ala Thr Gly Glu Asp Pro Glu Gly
                85                  90                  95      
Ser Asp Ile Leu Asn Tyr Phe Glu Ser Tyr Leu Ala Val Ala Ser Thr
            100                 105                 110         
Val Pro Ser Met Leu Cys Leu Val Ala Asn Phe Leu Leu Val Asn Arg
        115                 120                 125             
Val Ala Val His Ile Arg Val Leu Ala Ser Leu Thr Val Ile Leu Ala
    130                 135                 140                 
Ile Phe Met Val Ile Thr Ala Leu Val Lys Val Asp Thr Phe Ser Trp
145                 150                 155                 160 
Thr Arg Gly Phe Phe Ala Val Thr Ile Val Cys Met Val Ile Leu Ser
                165                 170                 175     
Gly Ala Ser Thr Val Phe Ser Ser Ser Ile Tyr Gly Met Thr Gly Ser
            180                 185                 190         
Phe Pro Met Arg Asn Ser Gln Ala Leu Ile Ser Gly Gly Ala Met Gly
        195                 200                 205             
Gly Thr Val Ser Ala Val Ala Ser Leu Val Asp Leu Ala Ala Ser Ser
    210                 215                 220                 
Asp Val Arg Asn Ser Ala Leu Ala Phe Phe Leu Thr Ala Thr Ile Phe
225                 230                 235                 240 
Leu Val Leu Cys Met Gly Leu Tyr Leu Leu Leu Ser Arg Leu Glu Tyr
                245                 250                 255     
Ala Arg Tyr Tyr Met Arg Pro Val Leu Ala Ala His Val Phe Ser Gly
            260                 265                 270         
Glu Glu Glu Leu Pro Gln Asp Ser Leu Ser Ala Pro Ser Val Ala Ser
        275                 280                 285             
Arg Phe Ile Asp Ser His Thr Pro Pro Leu Arg Pro Ile Leu Lys Lys
    290                 295                 300                 
Thr Ala Ser Leu Gly Phe Cys Val Thr Tyr Val Phe Phe Ile Thr Ser
305                 310                 315                 320 
Leu Ile Tyr Pro Ala Val Cys Thr Asn Ile Glu Ser Leu Asn Lys Gly
                325                 330                 335     
Ser Gly Ser Leu Trp Thr Thr Lys Phe Phe Ile Pro Leu Thr Thr Phe
            340                 345                 350         
Leu Leu Tyr Asn Phe Ala Asp Leu Cys Gly Arg Gln Leu Thr Ala Trp
        355                 360                 365             
Ile Gln Val Pro Gly Pro Asn Ser Lys Ala Leu Pro Gly Phe Val Leu
    370                 375                 380                 
Leu Arg Thr Cys Leu Ile Pro Leu Phe Val Leu Cys Asn Tyr Gln Pro
385                 390                 395                 400 
Arg Val His Leu Lys Thr Val Val Phe Gln Ser Asp Val Tyr Pro Ala
                405                 410                 415     
Leu Leu Ser Ser Leu Leu Gly Leu Ser Asn Gly Tyr Leu Ser Thr Leu
            420                 425                 430         
Ala Leu Leu Tyr Gly Pro Lys Ile Val Pro Arg Glu Leu Ala Glu Ala
        435                 440                 445             
Thr Gly Val Val Met Ser Phe Tyr Val Cys Leu Gly Leu Thr Leu Gly
    450                 455                 460                 
Ser Ala Cys Ser Thr Leu Leu Val His Leu Ile
465                 470                 475 


<210> 5980
<211> 125
<212> PRT
<213> Homo sapiens

<400> 5980
Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser
 1               5                  10                  15      
Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys
            20                  25                  30          
Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu
        35                  40                  45              
Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala
    50                  55                  60                  
Gly Cys Ala Thr Phe Cys Leu Leu Cys Pro Asn Asp Lys Glu Gly Ser
65                  70                  75                  80  
Cys Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp
                85                  90                  95      
Gln Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg
            100                 105                 110         
Asn Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe
        115                 120                 125 


<210> 5981
<211> 102
<212> PRT
<213> Homo sapiens

<400> 5981
Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser
 1               5                  10                  15      
Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys
            20                  25                  30          
Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu
        35                  40                  45              
Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala
    50                  55                  60                  
Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Ala Leu Phe His Trp His
65                  70                  75                  80  
Leu Lys Thr Arg Arg Leu Trp Glu Ile Ser Gly Pro Arg Pro Arg Arg
                85                  90                  95      
Pro Thr Trp Asp Ser Ser
            100         


<210> 5982
<211> 80
<212> PRT
<213> Homo sapiens

<400> 5982
Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser
 1               5                  10                  15      
Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys
            20                  25                  30          
Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu
        35                  40                  45              
Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala
    50                  55                  60                  
Gly Cys Ala Thr Phe Cys Leu Leu Cys Pro Asn Gly Gln Leu Ala Glu
65                  70                  75                  80  


<210> 5983
<211> 79
<212> PRT
<213> Homo sapiens

<400> 5983
Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser
 1               5                  10                  15      
Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys
            20                  25                  30          
Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu
        35                  40                  45              
Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala
    50                  55                  60                  
Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Gly Gln Leu Ala Glu
65                  70                  75                  


<210> 5984
<211> 510
<212> PRT
<213> Homo sapiens

<400> 5984
Met Arg Pro Gly Leu Ser Phe Leu Leu Ala Leu Leu Phe Phe Leu Gly
 1               5                  10                  15      
Gln Ala Ala Gly Asp Leu Gly Asp Val Gly Pro Pro Ile Pro Ser Pro
            20                  25                  30          
Gly Phe Ser Ser Phe Pro Gly Val Asp Ser Ser Ser Ser Phe Ser Ser
        35                  40                  45              
Ser Ser Arg Ser Gly Ser Ser Ser Ser Arg Ser Leu Gly Ser Gly Gly
    50                  55                  60                  
Ser Val Ser Gln Leu Phe Ser Asn Phe Thr Gly Ser Val Asp Asp Arg
65                  70                  75                  80  
Gly Thr Cys Gln Cys Ser Val Ser Leu Pro Asp Thr Thr Phe Pro Val
                85                  90                  95      
Asp Arg Val Glu Arg Leu Glu Phe Thr Ala His Val Leu Ser Gln Lys
            100                 105                 110         
Phe Glu Lys Glu Leu Ser Lys Val Arg Glu Tyr Val Gln Leu Ile Ser
        115                 120                 125             
Val Tyr Glu Lys Lys Leu Leu Asn Leu Thr Val Arg Ile Asp Ile Met
    130                 135                 140                 
Glu Lys Asp Thr Ile Ser Tyr Thr Glu Leu Asp Phe Glu Leu Ile Lys
145                 150                 155                 160 
Val Glu Val Lys Glu Met Glu Lys Leu Val Ile Gln Leu Lys Glu Ser
                165                 170                 175     
Phe Gly Gly Ser Ser Glu Ile Val Asp Gln Leu Glu Val Glu Ile Arg
            180                 185                 190         
Asn Met Thr Leu Leu Val Glu Lys Leu Glu Thr Leu Asp Lys Asn Asn
        195                 200                 205             
Val Leu Ala Ile Arg Arg Glu Ile Val Ala Leu Lys Thr Lys Leu Lys
    210                 215                 220                 
Glu Cys Glu Ala Ser Lys Asp Gln Asn Thr Pro Val Val His Pro Pro
225                 230                 235                 240 
Pro Thr Pro Gly Ser Cys Gly His Gly Gly Val Val Asn Ile Ser Lys
                245                 250                 255     
Pro Ser Val Val Gln Leu Asn Trp Arg Gly Phe Ser Tyr Leu Tyr Gly
            260                 265                 270         
Ala Trp Gly Arg Asp Tyr Ser Pro Gln His Pro Asn Lys Gly Leu Tyr
        275                 280                 285             
Trp Val Ala Pro Leu Asn Thr Asp Gly Arg Leu Leu Glu Tyr Tyr Arg
    290                 295                 300                 
Leu Tyr Asn Thr Leu Asp Asp Leu Leu Leu Tyr Ile Asn Ala Arg Glu
305                 310                 315                 320 
Leu Arg Ile Thr Tyr Gly Gln Gly Ser Gly Thr Ala Val Tyr Asn Asn
                325                 330                 335     
Asn Met Tyr Val Asn Met Tyr Asn Thr Gly Asn Ile Ala Arg Val Asn
            340                 345                 350         
Leu Thr Thr Asn Thr Ile Ala Val Thr Gln Thr Leu Pro Asn Ala Ala
        355                 360                 365             
Tyr Asn Asn Arg Phe Ser Tyr Ala Asn Val Ala Trp Gln Asp Ile Asp
    370                 375                 380                 
Phe Ala Val Asp Glu Asn Gly Leu Trp Val Ile Tyr Ser Thr Glu Ala
385                 390                 395                 400 
Ser Thr Gly Asn Met Val Ile Ser Lys Leu Asn Asp Thr Thr Leu Gln
                405                 410                 415     
Val Leu Asn Thr Trp Tyr Thr Lys Gln Tyr Lys Pro Ser Ala Ser Asn
            420                 425                 430         
Ala Phe Met Val Cys Gly Val Leu Tyr Ala Thr Arg Thr Met Asn Thr
        435                 440                 445             
Arg Thr Glu Glu Ile Phe Tyr Tyr Tyr Asp Thr Asn Thr Gly Lys Glu
    450                 455                 460                 
Gly Lys Leu Asp Ile Val Met His Lys Met Gln Glu Lys Val Gln Ser
465                 470                 475                 480 
Ile Asn Tyr Asn Pro Phe Asp Gln Lys Leu Tyr Val Tyr Asn Asp Gly
                485                 490                 495     
Tyr Leu Leu Asn Tyr Asp Leu Ser Val Leu Gln Lys Pro Gln
            500                 505                 510 


<210> 5985
<211> 161
<212> PRT
<213> Homo sapiens

<400> 5985
Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val
 1               5                  10                  15      
Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln
            20                  25                  30          
Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile
        35                  40                  45              
Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe
    50                  55                  60                  
Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe
65                  70                  75                  80  
Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser
                85                  90                  95      
Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser
            100                 105                 110         
Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val
        115                 120                 125             
Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu
    130                 135                 140                 
Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser
145                 150                 155                 160 
Leu
    


<210> 5986
<211> 478
<212> PRT
<213> Homo sapiens

<400> 5986
Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu
 1               5                  10                  15      
Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala
            20                  25                  30          
Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu
        35                  40                  45              
Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe
    50                  55                  60                  
Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr
65                  70                  75                  80  
Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn
                85                  90                  95      
Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val
            100                 105                 110         
Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro
        115                 120                 125             
Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile
    130                 135                 140                 
Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu
145                 150                 155                 160 
Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu
                165                 170                 175     
Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg
            180                 185                 190         
Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr
        195                 200                 205             
Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn
    210                 215                 220                 
Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp
225                 230                 235                 240 
Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe
                245                 250                 255     
His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp
            260                 265                 270         
Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln
        275                 280                 285             
Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn
    290                 295                 300                 
Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly
305                 310                 315                 320 
Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile
                325                 330                 335     
Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala
            340                 345                 350         
Ile Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp
        355                 360                 365             
Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln
    370                 375                 380                 
Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp
385                 390                 395                 400 
Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His
                405                 410                 415     
Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr
            420                 425                 430         
Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe
        435                 440                 445             
Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met
    450                 455                 460                 
Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr
465                 470                 475             


<210> 5987
<211> 784
<212> PRT
<213> Homo sapiens

<400> 5987
Met Leu Gly Val Glu Ile His Val Asn Val Glu Phe Val Lys Val Leu
 1               5                  10                  15      
Glu Pro Pro Glu Asp Gln Glu Asn Gln Lys Ile Gly Trp Arg Ala Glu
            20                  25                  30          
Phe Leu Pro Thr Gly His Ser Leu Ser Glu Phe Glu Phe Asp Val Ile
        35                  40                  45              
Ile Gly Ala Asp Gly Arg Arg Asn Thr Leu Glu Gly Phe Arg Arg Lys
    50                  55                  60                  
Glu Phe Arg Gly Lys Leu Ala Ile Ala Ile Thr Ala Asn Phe Ile Asn
65                  70                  75                  80  
Arg Asn Ser Thr Ala Glu Ala Lys Val Glu Glu Ile Ser Gly Val Ala
                85                  90                  95      
Phe Ile Phe Asn Gln Lys Phe Phe Gln Asp Leu Lys Glu Glu Thr Gly
            100                 105                 110         
Ile Asp Leu Glu Asn Ile Val Tyr Tyr Lys Asp Cys Ala His Tyr Phe
        115                 120                 125             
Val Met Thr Ala Lys Lys Gln Ser Leu Leu Asp Lys Gly Val Ile Ile
    130                 135                 140                 
Asn Asp Tyr Ile Asp Thr Glu Met Leu Leu Cys Ala Glu Asn Val Asn
145                 150                 155                 160 
Gln Asp Asn Leu Leu Ser Tyr Ala Arg Glu Ala Ala Asp Phe Ala Thr
                165                 170                 175     
Asn Tyr Gln Leu Pro Ser Leu Asp Phe Ala Met Asn His Tyr Gly Gln
            180                 185                 190         
Pro Asp Val Ala Met Phe Asp Phe Thr Cys Met Tyr Ala Ser Glu Asn
        195                 200                 205             
Ala Ala Leu Val Arg Glu Arg Gln Ala His Gln Leu Leu Val Ala Leu
    210                 215                 220                 
Val Gly Asp Ser Leu Leu Glu Pro Phe Trp Pro Met Gly Thr Gly Cys
225                 230                 235                 240 
Ala Arg Gly Phe Leu Ala Ala Phe Asp Thr Ala Trp Met Val Lys Ser
                245                 250                 255     
Trp Asn Gln Gly Thr Pro Pro Leu Glu Leu Leu Ala Glu Arg Glu Ser
            260                 265                 270         
Leu Tyr Arg Leu Leu Pro Gln Thr Thr Pro Glu Asn Ile Asn Lys Asn
        275                 280                 285             
Phe Glu Gln Tyr Thr Leu Asp Pro Gly Thr Arg Tyr Pro Asn Leu Asn
    290                 295                 300                 
Ser His Cys Val Arg Pro His Gln Val Lys His Leu Tyr Ile Thr Lys
305                 310                 315                 320 
Glu Leu Glu His Tyr Pro Leu Glu Arg Leu Gly Ser Val Arg Arg Ser
                325                 330                 335     
Val Asn Leu Ser Arg Lys Glu Ser Asp Ile Arg Pro Ser Lys Leu Leu
            340                 345                 350         
Thr Trp Cys Gln Gln Gln Thr Glu Gly Tyr Gln His Val Asn Val Thr
        355                 360                 365             
Asp Leu Thr Thr Ser Trp Arg Ser Gly Leu Ala Leu Cys Ala Ile Ile
    370                 375                 380                 
His Arg Phe Arg Pro Glu Leu Ile Asn Phe Asp Ser Leu Asn Glu Asp
385                 390                 395                 400 
Asp Ala Val Glu Asn Asn Gln Leu Ala Phe Asp Val Ala Glu Arg Glu
                405                 410                 415     
Phe Gly Ile Pro Pro Val Thr Thr Gly Lys Glu Met Ala Ser Ala Gln
            420                 425                 430         
Glu Pro Asp Lys Leu Ser Met Val Met Tyr Leu Ser Lys Phe Tyr Glu
        435                 440                 445             
Leu Phe Arg Gly Thr Pro Leu Arg Pro Val Asp Tyr Trp Arg Lys Asn
    450                 455                 460                 
Tyr Gly Glu Asn Ala Asp Leu Ser Leu Ala Lys Ser Ser Ile Ser Asn
465                 470                 475                 480 
Asn Tyr Leu Asn Leu Thr Phe Pro Arg Lys Arg Thr Pro Arg Val Asp
                485                 490                 495     
Gly Gln Thr Gly Glu Asn Asp Met Asn Lys Arg Arg Arg Lys Gly Phe
            500                 505                 510         
Thr Asn Leu Asp Glu Pro Ser Asn Phe Ser Ser Arg Ser Leu Gly Ser
        515                 520                 525             
Asn Gln Glu Cys Gly Ser Ser Lys Glu Gly Gly Asn Gln Asn Lys Val
    530                 535                 540                 
Lys Ser Met Ala Asn Gln Leu Leu Ala Lys Phe Glu Glu Ser Thr Arg
545                 550                 555                 560 
Asn Pro Ser Leu Met Lys Gln Glu Ser Met Arg Lys Ser Phe Pro Leu
                565                 570                 575     
Asn Leu Gly Gly Ser Asp Thr Cys Tyr Phe Cys Lys Lys Arg Val Tyr
            580                 585                 590         
Val Met Glu Arg Leu Ser Ala Glu Gly His Phe Phe His Arg Glu Cys
        595                 600                 605             
Phe Arg Cys Ser Ile Cys Ala Thr Thr Leu Arg Leu Ala Ala Tyr Thr
    610                 615                 620                 
Phe Asp Cys Asp Glu Gly Lys Phe Tyr Cys Lys Pro His Phe Ile His
625                 630                 635                 640 
Cys Lys Thr Asn Ser Lys Gln Arg Lys Arg Arg Ala Glu Leu Lys Gln
                645                 650                 655     
Gln Arg Glu Glu Glu Ala Thr Trp Gln Glu Gln Glu Ala Pro Arg Arg
            660                 665                 670         
Asp Thr Pro Thr Glu Ser Ser Cys Ala Val Ala Ala Ile Gly Thr Leu
        675                 680                 685             
Glu Gly Ser Pro Pro Gly Ile Ser Thr Ser Phe Phe Arg Lys Val Leu
    690                 695                 700                 
Gly Trp Pro Leu Arg Leu Pro Arg Asp Leu Cys Asn Trp Met Gln Gly
705                 710                 715                 720 
Leu Leu Gln Ala Ala Gly Leu His Ile Arg Asp Asn Ala Tyr Asn Tyr
                725                 730                 735     
Cys Tyr Met Tyr Glu Leu Leu Ser Leu Gly Leu Pro Leu Leu Trp Ala
            740                 745                 750         
Phe Ser Glu Val Leu Ala Ala Met Tyr Arg Glu Ser Glu Gly Ser Leu
        755                 760                 765             
Glu Ser Ile Cys Asn Trp Val Leu Arg Cys Phe Pro Val Lys Leu Arg
    770                 775                 780                 


<210> 5988
<211> 1125
<212> PRT
<213> Homo sapiens

<400> 5988
Met Gly Glu Asn Glu Asp Glu Lys Gln Ala Gln Ala Gly Gln Val Phe
 1               5                  10                  15      
Glu Asn Phe Val Gln Ala Ser Thr Cys Lys Gly Thr Leu Gln Ala Phe
            20                  25                  30          
Asn Ile Leu Thr Arg His Leu Asp Leu Asp Pro Leu Asp His Arg Asn
        35                  40                  45              
Phe Tyr Ser Lys Leu Lys Ser Lys Val Thr Thr Trp Lys Ala Lys Ala
    50                  55                  60                  
Leu Trp Tyr Lys Leu Asp Lys Arg Gly Ser His Lys Glu Tyr Lys Arg
65                  70                  75                  80  
Gly Lys Ser Cys Thr Asn Thr Lys Cys Leu Ile Val Gly Gly Gly Pro
                85                  90                  95      
Cys Gly Leu Arg Thr Ala Ile Glu Leu Ala Tyr Leu Gly Ala Lys Val
            100                 105                 110         
Val Val Val Glu Lys Arg Asp Ser Phe Ser Arg Asn Asn Val Leu His
        115                 120                 125             
Leu Trp Pro Phe Thr Ile His Asp Leu Arg Gly Leu Gly Ala Lys Lys
    130                 135                 140                 
Phe Tyr Gly Lys Phe Cys Ala Gly Ser Ile Asp His Ile Ser Ile Arg
145                 150                 155                 160 
Gln Leu Gln Leu Ile Leu Phe Lys Val Ala Leu Met Leu Gly Val Glu
                165                 170                 175     
Ile His Val Asn Val Glu Phe Val Lys Val Leu Glu Pro Pro Glu Asp
            180                 185                 190         
Gln Glu Asn Gln Lys Ile Gly Trp Arg Ala Glu Phe Leu Pro Thr Asp
        195                 200                 205             
His Ser Leu Ser Glu Phe Glu Phe Asp Val Ile Ile Gly Ala Asp Gly
    210                 215                 220                 
Arg Arg Asn Thr Leu Glu Gly Phe Arg Arg Lys Glu Phe Arg Gly Lys
225                 230                 235                 240 
Leu Ala Ile Ala Ile Thr Ala Asn Phe Ile Asn Arg Asn Ser Thr Ala
                245                 250                 255     
Glu Ala Lys Val Glu Glu Ile Ser Gly Val Ala Phe Ile Phe Asn Gln
            260                 265                 270         
Lys Phe Phe Gln Asp Leu Lys Glu Glu Thr Gly Ile Asp Leu Glu Asn
        275                 280                 285             
Ile Val Tyr Tyr Lys Asp Cys Thr His Tyr Phe Val Met Thr Ala Lys
    290                 295                 300                 
Lys Gln Ser Leu Leu Asp Lys Gly Val Ile Ile Asn Asp Tyr Ile Asp
305                 310                 315                 320 
Thr Glu Met Leu Leu Cys Ala Glu Asn Val Asn Gln Asp Asn Leu Leu
                325                 330                 335     
Ser Tyr Ala Arg Glu Ala Ala Asp Phe Ala Thr Asn Tyr Gln Leu Pro
            340                 345                 350         
Ser Leu Asp Phe Ala Met Asn His Tyr Gly Gln Pro Asp Val Ala Met
        355                 360                 365             
Phe Asp Phe Thr Cys Met Tyr Ala Ser Glu Asn Ala Ala Leu Val Arg
    370                 375                 380                 
Glu Arg Gln Ala His Gln Leu Leu Val Ala Leu Val Gly Asp Ser Leu
385                 390                 395                 400 
Leu Glu Pro Phe Trp Pro Met Gly Thr Gly Cys Ala Arg Gly Phe Leu
                405                 410                 415     
Ala Ala Phe Asp Thr Ala Trp Met Val Lys Ser Trp Asn Gln Gly Thr
            420                 425                 430         
Pro Pro Leu Glu Leu Leu Ala Glu Arg Glu Ser Leu Tyr Arg Leu Leu
        435                 440                 445             
Pro Gln Thr Thr Pro Glu Asn Ile Asn Lys Asn Phe Glu Gln Tyr Thr
    450                 455                 460                 
Leu Asp Pro Gly Thr Arg Tyr Pro Asn Leu Asn Ser His Cys Val Arg
465                 470                 475                 480 
Pro His Gln Ala Ser Lys His Leu Tyr Ile Thr Lys Glu Leu Glu His
                485                 490                 495     
Tyr Pro Leu Glu Arg Leu Gly Ser Val Arg Arg Ser Val Asn Leu Ser
            500                 505                 510         
Arg Lys Glu Ser Asp Ile Arg Pro Ser Lys Leu Leu Thr Trp Cys Gln
        515                 520                 525             
Gln Gln Thr Glu Gly Tyr Gln His Val Asn Val Thr Asp Leu Thr Thr
    530                 535                 540                 
Ser Trp Arg Ser Gly Leu Ala Leu Cys Ala Ile Ile His Arg Phe Arg
545                 550                 555                 560 
Pro Glu Leu Ile Asn Phe Asp Ser Leu Asn Glu Asp Asp Ala Val Glu
                565                 570                 575     
Asn Asn Gln Leu Ala Phe Asp Val Ala Glu Arg Glu Phe Gly Ile Pro
            580                 585                 590         
Pro Val Thr Thr Gly Lys Glu Met Ala Ser Ala Gln Glu Pro Asp Lys
        595                 600                 605             
Leu Ser Met Val Met Tyr Leu Ser Lys Phe Tyr Glu Leu Phe Arg Gly
    610                 615                 620                 
Thr Pro Leu Arg Pro Val Asp Ser Trp Arg Lys Asn Tyr Gly Glu Asn
625                 630                 635                 640 
Ala Asp Leu Ser Leu Ala Lys Ser Ser Ile Ser Asn Asn Tyr Leu Asn
                645                 650                 655     
Leu Thr Phe Pro Arg Lys Arg Thr Pro Arg Val Asp Gly Gln Thr Gly
            660                 665                 670         
Glu Asn Asp Met Asn Lys Arg Arg Arg Lys Gly Phe Thr Asn Leu Asp
        675                 680                 685             
Glu Pro Ser Asn Phe Ser Ser Arg Ser Leu Gly Ser Asn Gln Glu Cys
    690                 695                 700                 
Gly Ser Ser Lys Glu Gly Gly Asn Gln Asn Lys Val Lys Ser Met Ala
705                 710                 715                 720 
Asn Gln Leu Leu Ala Lys Phe Glu Glu Ser Thr Arg Asn Pro Ser Leu
                725                 730                 735     
Met Lys Gln Glu Arg Arg Val Ser Gly Ile Gly Lys Pro Val Leu Cys
            740                 745                 750         
Ser Ser Ser Gly Pro Pro Val His Ser Cys Cys Pro Lys Pro Glu Glu
        755                 760                 765             
Ala Thr Pro Ser Pro Ser Pro Pro Leu Lys Arg Gln Phe Pro Ser Val
    770                 775                 780                 
Val Val Thr Gly His Val Leu Arg Glu Leu Lys Gln Val Ser Ala Gly
785                 790                 795                 800 
Ser Glu Cys Leu Ser Arg Pro Trp Arg Ala Arg Ala Lys Ser Asp Leu
                805                 810                 815     
Gln Leu Gly Gly Thr Glu Asn Phe Ala Thr Leu Pro Ser Thr Arg Pro
            820                 825                 830         
Arg Ala Gln Ala Leu Ser Gly Val Leu Trp Arg Leu Gln Gln Val Glu
        835                 840                 845             
Glu Lys Ile Leu Gln Lys Arg Ala Gln Asn Leu Ala Asn Arg Glu Phe
    850                 855                 860                 
His Thr Lys Asn Ile Lys Glu Lys Ala Ala His Leu Ala Ser Met Phe
865                 870                 875                 880 
Gly His Gly Asp Phe Pro Gln Asn Lys Leu Leu Ser Lys Gly Leu Ser
                885                 890                 895     
His Thr His Pro Pro Ser Pro Pro Ser Arg Leu Pro Ser Pro Asp Pro
            900                 905                 910         
Ala Ala Ser Ser Ser Pro Ser Thr Val Asp Ser Ala Ser Pro Ala Arg
        915                 920                 925             
Lys Glu Lys Lys Ser Pro Ser Gly Phe His Phe His Pro Ser His Leu
    930                 935                 940                 
Arg Thr Val His Pro Gln Leu Thr Val Gly Lys Val Ser Ser Gly Ile
945                 950                 955                 960 
Gly Ala Ala Ala Glu Val Leu Val Asn Leu Tyr Met Asn Asp His Arg
                965                 970                 975     
Pro Lys Ala Gln Ala Thr Ser Pro Asp Leu Glu Ser Met Arg Lys Ser
            980                 985                 990         
Phe Pro Leu Asn Leu Gly Gly Ser Asp Thr Cys Tyr Phe Cys Lys Lys
        995                 1000                1005            
Arg Val Tyr Val Met Glu Arg Leu Ser Ala Glu Gly His Phe Phe His
    1010                1015                1020                
Arg Glu Cys Phe Arg Cys Ser Ile Cys Ala Thr Thr Leu Arg Leu Ala
1025                1030                1035                1040
Ala Tyr Thr Phe Asp Cys Asp Glu Gly Lys Phe Tyr Cys Lys Pro His
                1045                1050                1055    
Phe Ile His Cys Lys Thr Asn Ser Lys Gln Arg Lys Arg Arg Ala Glu
            1060                1065                1070        
Leu Lys Gln Gln Arg Glu Glu Glu Ala Thr Trp Gln Glu Gln Glu Ala
        1075                1080                1085            
Pro Arg Arg Asp Thr Pro Thr Glu Ser Ser Cys Ala Val Ala Ala Ile
    1090                1095                1100                
Gly Thr Leu Glu Gly Ser Pro Pro Val His Phe Ser Leu Pro Val Leu
1105                1110                1115                1120
His Pro Leu Leu Gly
                1125


<210> 5989
<211> 453
<212> PRT
<213> Homo sapiens

<400> 5989
Met Ala Leu Val Arg Ala Leu Val Cys Cys Leu Leu Thr Ala Trp His
 1               5                  10                  15      
Cys Arg Ser Gly Leu Gly Leu Pro Val Ala Pro Ala Gly Gly Arg Asn
            20                  25                  30          
Pro Pro Pro Ala Ile Gly Gln Phe Trp His Val Thr Asp Leu His Leu
        35                  40                  45              
Asp Pro Thr Tyr His Ile Thr Asp Asp His Thr Lys Val Cys Ala Ser
    50                  55                  60                  
Ser Lys Gly Ala Asn Ala Ser Asn Pro Gly Pro Phe Gly Asp Val Leu
65                  70                  75                  80  
Cys Asp Ser Pro Tyr Gln Leu Ile Leu Ser Ala Phe Asp Phe Ile Lys
                85                  90                  95      
Asn Ser Gly Gln Glu Ala Ser Phe Met Ile Trp Thr Gly Asp Ser Pro
            100                 105                 110         
Pro His Val Pro Val Pro Glu Leu Ser Thr Asp Thr Val Ile Asn Val
        115                 120                 125             
Ile Thr Asn Met Thr Thr Thr Ile Gln Ser Leu Phe Pro Asn Leu Gln
    130                 135                 140                 
Val Phe Pro Ala Leu Gly Asn His Asp Tyr Trp Pro Gln Asp Gln Leu
145                 150                 155                 160 
Pro Val Val Thr Ser Lys Val Tyr Asn Ala Val Ala Asn Leu Trp Lys
                165                 170                 175     
Pro Trp Leu Asp Glu Glu Ala Ile Ser Thr Leu Arg Lys Gly Gly Phe
            180                 185                 190         
Tyr Ser Gln Lys Val Thr Thr Asn Pro Asn Leu Arg Ile Ile Ser Leu
        195                 200                 205             
Asn Thr Asn Leu Tyr Tyr Gly Pro Asn Ile Met Thr Leu Asn Lys Thr
    210                 215                 220                 
Asp Pro Ala Asn Gln Phe Glu Trp Leu Glu Ser Thr Leu Asn Asn Ser
225                 230                 235                 240 
Gln Gln Asn Lys Glu Lys Val Tyr Ile Ile Ala His Val Pro Val Gly
                245                 250                 255     
Tyr Leu Pro Ser Ser Gln Asn Ile Thr Ala Met Arg Glu Tyr Tyr Asn
            260                 265                 270         
Glu Lys Leu Ile Asp Ile Phe Gln Lys Tyr Ser Asp Val Ile Ala Gly
        275                 280                 285             
Gln Phe Tyr Gly His Thr His Arg Asp Ser Ile Met Val Leu Ser Asp
    290                 295                 300                 
Lys Lys Gly Ser Pro Val Asn Ser Leu Phe Val Ala Pro Ala Val Thr
305                 310                 315                 320 
Pro Val Lys Ser Val Leu Glu Lys Gln Thr Asn Asn Pro Gly Ile Arg
                325                 330                 335     
Leu Phe Gln Tyr Asp Pro Arg Asp Tyr Lys Leu Leu Asp Met Leu Gln
            340                 345                 350         
Tyr Tyr Leu Asn Leu Thr Glu Ala Asn Leu Lys Gly Glu Ser Ile Trp
        355                 360                 365             
Lys Leu Glu Tyr Ile Leu Thr Gln Thr Tyr Asp Ile Glu Asp Leu Gln
    370                 375                 380                 
Pro Glu Ser Leu Tyr Gly Leu Ala Lys Gln Phe Thr Ile Leu Asp Ser
385                 390                 395                 400 
Lys Gln Phe Ile Lys Tyr Tyr Asn Tyr Phe Phe Val Ser Tyr Asp Ser
                405                 410                 415     
Ser Val Thr Cys Asp Lys Thr Cys Lys Ala Phe Gln Ile Cys Ala Ile
            420                 425                 430         
Met Asn Leu Asp Asn Ile Ser Tyr Ala Asp Cys Leu Lys Gln Leu Tyr
        435                 440                 445             
Ile Lys His Asn Tyr
    450             


<210> 5990
<211> 323
<212> PRT
<213> Homo sapiens

<400> 5990
Met Ala Arg Gly Pro Gly Leu Ala Pro Pro Pro Leu Arg Leu Pro Leu
 1               5                  10                  15      
Leu Leu Leu Val Leu Ala Ala Val Thr Gly His Thr Ala Ala Gln Asp
            20                  25                  30          
Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser Pro Asp Gly
        35                  40                  45              
Pro Gly Gly Arg Cys Gln Cys Arg Ala Leu Gly Ser Gly Met Ala Val
    50                  55                  60                  
Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met
65                  70                  75                  80  
Ser Ala Pro Lys Asn Ala Arg Thr Leu Val Arg Pro Ser Glu His Ala
                85                  90                  95      
Leu Val Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Pro Glu Gly
            100                 105                 110         
Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val
        115                 120                 125             
Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Leu Ser Leu Arg
    130                 135                 140                 
Cys Asp Asp Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His
145                 150                 155                 160 
Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu
                165                 170                 175     
Arg Arg Leu Phe Arg Glu Arg Tyr Arg Leu His Pro Lys Phe Val Ala
            180                 185                 190         
Ala Val His Tyr Glu Gln Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn
        195                 200                 205             
Thr Ser Gln Lys Ala Ala Gly Glu Val Asp Ile Gly Asp Ala Ala Tyr
    210                 215                 220                 
Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Gln Gly Arg Gly
225                 230                 235                 240 
Gly Leu Asp Leu Arg Val Arg Gly Glu Pro Leu Gln Val Glu Arg Thr
                245                 250                 255     
Leu Ile Tyr Tyr Leu Asp Glu Ile Pro Pro Lys Phe Ser Met Lys Arg
            260                 265                 270         
Leu Thr Ala Gly Leu Ile Ala Val Ile Val Val Val Val Val Ala Leu
        275                 280                 285             
Val Ala Gly Met Ala Val Leu Val Ile Thr Asn Arg Arg Lys Ser Gly
    290                 295                 300                 
Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Lys Glu
305                 310                 315                 320 
Pro Ser Leu
            


<210> 5991
<211> 628
<212> PRT
<213> Homo sapiens

<400> 5991
Met Ala Leu Gln Arg Leu Asp Pro Cys Trp Ser Cys Gly Asp Arg Pro
 1               5                  10                  15      
Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val His Pro Ala
            20                  25                  30          
Arg Thr Leu Ala Gly Glu Thr Gly Thr Glu Ser Ala Pro Leu Gly Gly
        35                  40                  45              
Val Leu Thr Thr Pro His Asn Ile Ser Ser Leu Ser Pro Arg Gln Leu
    50                  55                  60                  
Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu Arg Val
65                  70                  75                  80  
Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu Ser Thr
                85                  90                  95      
Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro Glu Asp
            100                 105                 110         
Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro Asp Ala
        115                 120                 125             
Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile Thr Lys
    130                 135                 140                 
Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln Arg Leu
145                 150                 155                 160 
Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu Leu Ser
                165                 170                 175     
Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu Pro Gly
            180                 185                 190         
Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu Val Ser
        195                 200                 205             
Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg Ala Ala
    210                 215                 220                 
Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp Ser Val
225                 230                 235                 240 
Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly Gln Pro
                245                 250                 255     
Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg Gln Arg
            260                 265                 270         
Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile Leu Arg
        275                 280                 285             
Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys
    290                 295                 300                 
Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu
305                 310                 315                 320 
Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg
                325                 330                 335     
Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His
            340                 345                 350         
Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln
        355                 360                 365             
His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys
    370                 375                 380                 
Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asp
385                 390                 395                 400 
Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu Pro Gln
                405                 410                 415     
Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln Leu Asp
            420                 425                 430         
Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys
        435                 440                 445             
Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser Ile Trp
    450                 455                 460                 
Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp
465                 470                 475                 480 
Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn Gly Ser
                485                 490                 495     
Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu
            500                 505                 510         
Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu Ala Thr
        515                 520                 525             
Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val Ala Glu
    530                 535                 540                 
Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala Glu Glu
545                 550                 555                 560 
Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp
                565                 570                 575     
Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr
            580                 585                 590         
Leu Val Leu Asp Leu Ser Val Gln Glu Thr Leu Ser Gly Thr Pro Cys
        595                 600                 605             
Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu Leu Ala
    610                 615                 620                 
Ser Thr Leu Ala
625             


<210> 5992
<211> 398
<212> PRT
<213> Homo sapiens

<400> 5992
Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile Asp
 1               5                  10                  15      
Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val Asp
            20                  25                  30          
Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro Phe
        35                  40                  45              
Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu Tyr
    50                  55                  60                  
Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr Leu Phe
65                  70                  75                  80  
Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr Ser Leu
                85                  90                  95      
Glu Thr Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu Met Ser
            100                 105                 110         
Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln
        115                 120                 125             
Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr
    130                 135                 140                 
Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser
145                 150                 155                 160 
Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln
                165                 170                 175     
Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn
            180                 185                 190         
Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro
        195                 200                 205             
Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu
    210                 215                 220                 
Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val
225                 230                 235                 240 
Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala
                245                 250                 255     
Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln
            260                 265                 270         
Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn
        275                 280                 285             
Gly Tyr Leu Val Leu Asp Leu Ser Val Gln Gly Gly Arg Gly Gly Gln
    290                 295                 300                 
Ala Arg Ala Gly Gly Arg Ala Gly Gly Val Glu Val Gly Ala Leu Ser
305                 310                 315                 320 
His Pro Ser Leu Cys Arg Gly Pro Leu Gly Asp Ala Leu Pro Pro Arg
                325                 330                 335     
Thr Trp Thr Cys Ser His Arg Pro Gly Thr Ala Pro Ser Leu His Pro
            340                 345                 350         
Gly Leu Arg Ala Pro Leu Pro Cys Trp Pro Gln Pro Cys Trp Gly Ser
        355                 360                 365             
Pro Pro Gly Gln Glu Gln Ala Arg Val Ile Pro Val Pro Pro Gln Glu
    370                 375                 380                 
Asn Ser Arg Ser Val Asn Gly Asn Met Pro Pro Ala Asp Thr
385                 390                 395             


<210> 5993
<211> 622
<212> PRT
<213> Homo sapiens

<400> 5993
Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro
 1               5                  10                  15      
Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln
            20                  25                  30          
Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu
        35                  40                  45              
Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg
    50                  55                  60                  
Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu
65                  70                  75                  80  
Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu
                85                  90                  95      
Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro
            100                 105                 110         
Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro
        115                 120                 125             
Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile
    130                 135                 140                 
Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln
145                 150                 155                 160 
Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu
                165                 170                 175     
Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu
            180                 185                 190         
Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu
        195                 200                 205             
Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg
    210                 215                 220                 
Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp
225                 230                 235                 240 
Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly
                245                 250                 255     
Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg
            260                 265                 270         
Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile
        275                 280                 285             
Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser
    290                 295                 300                 
Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys
305                 310                 315                 320 
Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met
                325                 330                 335     
Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu
            340                 345                 350         
Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val
        355                 360                 365             
Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile
    370                 375                 380                 
Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu
385                 390                 395                 400 
Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp
                405                 410                 415     
Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr
            420                 425                 430         
Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu
        435                 440                 445             
Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp
    450                 455                 460                 
Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala
465                 470                 475                 480 
Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile
                485                 490                 495     
Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser
            500                 505                 510         
Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr
        515                 520                 525             
Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly
    530                 535                 540                 
Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg
545                 550                 555                 560 
Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu
                565                 570                 575     
Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser
            580                 585                 590         
Val Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro
        595                 600                 605             
Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala
    610                 615                 620         


<210> 5994
<211> 232
<212> PRT
<213> Homo sapiens

<400> 5994
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15      
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30          
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45              
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60                  
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80  
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95      
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110         
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125             
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140                 
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160 
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175     
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190         
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205             
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
    210                 215                 220                 
Gln Asp Leu Gly Pro Val Pro Met
225                 230         


<210> 5995
<211> 296
<212> PRT
<213> Homo sapiens

<400> 5995
Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val
 1               5                  10                  15      
Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met
            20                  25                  30          
Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala
        35                  40                  45              
Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln
    50                  55                  60                  
Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys
65                  70                  75                  80  
Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys
                85                  90                  95      
Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro
            100                 105                 110         
Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met
        115                 120                 125             
Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His
    130                 135                 140                 
Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly
145                 150                 155                 160 
Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile
                165                 170                 175     
Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu
            180                 185                 190         
Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys
        195                 200                 205             
Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His
    210                 215                 220                 
Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro
225                 230                 235                 240 
Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn
                245                 250                 255     
Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser
            260                 265                 270         
Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys
        275                 280                 285             
Gln Asp Leu Gly Pro Val Pro Met
    290                 295     


<210> 5996
<211> 524
<212> PRT
<213> Homo sapiens

<400> 5996
Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn
 1               5                  10                  15      
Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln
            20                  25                  30          
Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr
        35                  40                  45              
Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val
    50                  55                  60                  
Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn
65                  70                  75                  80  
Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala
                85                  90                  95      
Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly
            100                 105                 110         
Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val
        115                 120                 125             
Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly
    130                 135                 140                 
Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser
145                 150                 155                 160 
Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala
                165                 170                 175     
Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met
            180                 185                 190         
Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu
        195                 200                 205             
Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys
    210                 215                 220                 
Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu
225                 230                 235                 240 
Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp
                245                 250                 255     
Lys Ser Phe Lys Pro Arg His Lys His Ser His Phe Ile Trp Asn Arg
            260                 265                 270         
Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly
        275                 280                 285             
Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val
    290                 295                 300                 
Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu
305                 310                 315                 320 
Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile
                325                 330                 335     
Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala
            340                 345                 350         
Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser
        355                 360                 365             
Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr
    370                 375                 380                 
Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro
385                 390                 395                 400 
Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly
                405                 410                 415     
Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser
            420                 425                 430         
Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro
        435                 440                 445             
Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys
    450                 455                 460                 
Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val
465                 470                 475                 480 
Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His
                485                 490                 495     
Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu
            500                 505                 510         
Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe
        515                 520                 


<210> 5997
<211> 645
<212> PRT
<213> Homo sapiens

<400> 5997
Met Ser Cys Gln Ile Ser Cys Lys Ser Arg Gly Arg Gly Gly Gly Gly
 1               5                  10                  15      
Gly Gly Phe Arg Gly Phe Ser Ser Gly Ser Ala Val Val Ser Gly Gly
            20                  25                  30          
Ser Arg Arg Ser Thr Ser Ser Phe Ser Cys Leu Ser Arg His Gly Gly
        35                  40                  45              
Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Ser Arg Ser Leu Val
    50                  55                  60                  
Gly Leu Gly Gly Thr Lys Ser Ile Ser Ile Ser Val Ala Gly Gly Gly
65                  70                  75                  80  
Gly Gly Phe Gly Ala Ala Gly Gly Phe Gly Gly Arg Gly Gly Gly Phe
                85                  90                  95      
Gly Gly Gly Ser Gly Phe Gly Gly Gly Ser Gly Phe Gly Gly Gly Ser
            100                 105                 110         
Gly Phe Ser Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly Arg
        115                 120                 125             
Phe Gly Gly Phe Gly Gly Pro Gly Gly Val Gly Gly Leu Gly Gly Pro
    130                 135                 140                 
Gly Gly Phe Gly Pro Gly Gly Tyr Pro Gly Gly Ile His Glu Val Ser
145                 150                 155                 160 
Val Asn Gln Ser Leu Leu Gln Pro Leu Asn Val Lys Val Asp Pro Glu
                165                 170                 175     
Ile Gln Asn Val Lys Ala Gln Glu Arg Glu Gln Ile Lys Thr Leu Asn
            180                 185                 190         
Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln
        195                 200                 205             
Asn Gln Val Leu Gln Thr Lys Trp Glu Leu Leu Gln Gln Met Asn Val
    210                 215                 220                 
Gly Thr Arg Pro Ile Asn Leu Glu Pro Ile Phe Gln Gly Tyr Ile Asp
225                 230                 235                 240 
Ser Leu Lys Arg Tyr Leu Asp Gly Leu Thr Ala Glu Arg Thr Ser Gln
                245                 250                 255     
Asn Ser Glu Leu Asn Asn Met Gln Asp Leu Val Glu Asp Tyr Lys Lys
            260                 265                 270         
Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Asp Phe
        275                 280                 285             
Val Thr Leu Lys Lys Asp Val Asp Asn Ala Tyr Met Ile Lys Val Glu
    290                 295                 300                 
Leu Gln Ser Lys Val Asp Leu Leu Asn Gln Glu Ile Glu Phe Leu Lys
305                 310                 315                 320 
Val Leu Tyr Asp Ala Glu Ile Ser Gln Ile His Gln Ser Val Thr Asp
                325                 330                 335     
Thr Asn Val Ile Leu Ser Met Asp Asn Ser Arg Asn Leu Asp Leu Asp
            340                 345                 350         
Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg
        355                 360                 365             
Ser Lys Glu Glu Ala Glu Ala Leu Tyr His Ser Lys Tyr Glu Glu Leu
    370                 375                 380                 
Gln Val Thr Val Gly Arg His Gly Asp Ser Leu Lys Glu Ile Lys Ile
385                 390                 395                 400 
Glu Ile Ser Glu Leu Asn Arg Val Ile Gln Arg Leu Gln Gly Glu Ile
                405                 410                 415     
Ala His Val Lys Lys Gln Cys Lys Asn Val Gln Asp Ala Ile Ala Asp
            420                 425                 430         
Ala Glu Gln Arg Gly Glu His Ala Leu Lys Asp Ala Arg Asn Lys Leu
        435                 440                 445             
Asn Asp Leu Glu Glu Ala Leu Gln Gln Ala Lys Glu Asp Leu Ala Arg
    450                 455                 460                 
Leu Leu Arg Asp Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp
465                 470                 475                 480 
Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg
                485                 490                 495     
Met Ser Gly Asp Leu Ser Ser Asn Val Thr Val Ser Val Thr Ser Ser
            500                 505                 510         
Thr Ile Ser Ser Asn Val Ala Ser Lys Ala Ala Phe Gly Gly Ser Gly
        515                 520                 525             
Gly Arg Gly Ser Ser Ser Gly Gly Gly Tyr Ser Ser Gly Ser Ser Ser
    530                 535                 540                 
Tyr Gly Ser Gly Gly Arg Gln Ser Gly Ser Arg Gly Gly Ser Gly Gly
545                 550                 555                 560 
Gly Gly Ser Ile Ser Gly Gly Gly Tyr Gly Ser Gly Gly Gly Ser Gly
                565                 570                 575     
Gly Arg Tyr Gly Ser Gly Gly Gly Ser Lys Gly Gly Ser Ile Ser Gly
            580                 585                 590         
Gly Gly Tyr Gly Ser Gly Gly Gly Lys His Ser Ser Gly Gly Gly Ser
        595                 600                 605             
Arg Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Ser Gly Gly Gly Gly
    610                 615                 620                 
Ser Ser Ser Val Lys Gly Ser Ser Gly Glu Ala Phe Gly Ser Ser Val
625                 630                 635                 640 
Thr Phe Ser Phe Arg
                645 


<210> 5998
<211> 644
<212> PRT
<213> Homo sapiens

<400> 5998
Met Ser Arg Gln Phe Ser Ser Arg Ser Gly Tyr Arg Ser Gly Gly Gly
 1               5                  10                  15      
Phe Ser Ser Gly Ser Ala Gly Ile Ile Asn Tyr Gln Arg Arg Thr Thr
            20                  25                  30          
Ser Ser Ser Thr Arg Arg Ser Gly Gly Gly Gly Gly Arg Phe Ser Ser
        35                  40                  45              
Cys Gly Gly Gly Gly Gly Ser Phe Gly Ala Gly Gly Gly Phe Gly Ser
    50                  55                  60                  
Arg Ser Leu Val Asn Leu Gly Gly Ser Lys Ser Ile Ser Ile Ser Val
65                  70                  75                  80  
Ala Arg Gly Gly Gly Arg Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly
                85                  90                  95      
Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly
            100                 105                 110         
Gly Ile Gly Gly Gly Gly Phe Gly Gly Phe Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Tyr Gly Gly Gly Tyr Gly
    130                 135                 140                 
Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Ile Asn Gln Ser
145                 150                 155                 160 
Leu Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Glu Ile Gln Lys Val
                165                 170                 175     
Lys Ser Arg Glu Arg Glu Gln Ile Lys Ser Leu Asn Asn Gln Phe Ala
            180                 185                 190         
Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu
        195                 200                 205             
Gln Thr Lys Trp Glu Leu Leu Gln Gln Val Asp Thr Ser Thr Arg Thr
    210                 215                 220                 
His Asn Leu Glu Pro Tyr Phe Glu Ser Phe Ile Asn Asn Leu Arg Arg
225                 230                 235                 240 
Arg Val Asp Gln Leu Lys Ser Asp Gln Ser Arg Leu Asp Ser Glu Leu
                245                 250                 255     
Lys Asn Met Gln Asp Met Val Glu Asp Tyr Arg Asn Lys Tyr Glu Asp
            260                 265                 270         
Glu Ile Asn Lys Arg Thr Asn Ala Glu Asn Glu Phe Val Thr Ile Lys
        275                 280                 285             
Lys Asp Val Asp Gly Ala Tyr Met Thr Lys Val Asp Leu Gln Ala Lys
    290                 295                 300                 
Leu Asp Asn Leu Gln Gln Glu Ile Asp Phe Leu Thr Ala Leu Tyr Gln
305                 310                 315                 320 
Ala Glu Leu Ser Gln Met Gln Thr Gln Ile Ser Glu Thr Asn Val Ile
                325                 330                 335     
Leu Ser Met Asp Asn Asn Arg Ser Leu Asp Leu Asp Ser Ile Ile Ala
            340                 345                 350         
Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Gln Lys Ser Lys Ala Glu
        355                 360                 365             
Ala Glu Ser Leu Tyr Gln Ser Lys Tyr Glu Glu Leu Gln Ile Thr Ala
    370                 375                 380                 
Gly Arg His Gly Asp Ser Val Arg Asn Ser Lys Ile Glu Ile Ser Glu
385                 390                 395                 400 
Leu Asn Arg Val Ile Gln Arg Leu Arg Ser Glu Ile Asp Asn Val Lys
                405                 410                 415     
Lys Gln Ile Ser Asn Leu Gln Gln Ser Ile Ser Asp Ala Glu Gln Arg
            420                 425                 430         
Gly Glu Asn Ala Leu Lys Asp Ala Lys Asn Lys Leu Asn Asp Leu Glu
        435                 440                 445             
Asp Ala Leu Gln Gln Ala Lys Glu Asp Leu Ala Arg Leu Leu Arg Asp
    450                 455                 460                 
Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp Leu Glu Ile Ala
465                 470                 475                 480 
Thr Tyr Arg Thr Leu Leu Glu Gly Glu Glu Ser Arg Met Ser Gly Glu
                485                 490                 495     
Cys Ala Pro Asn Val Ser Val Ser Val Ser Thr Ser His Thr Thr Ile
            500                 505                 510         
Ser Gly Gly Gly Ser Arg Gly Gly Gly Gly Gly Gly Tyr Gly Ser Gly
        515                 520                 525             
Gly Ser Ser Tyr Gly Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly
    530                 535                 540                 
Gly Gly Gly Gly Arg Gly Ser Tyr Gly Ser Gly Gly Ser Ser Tyr Gly
545                 550                 555                 560 
Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly Gly Gly Gly His Gly
                565                 570                 575     
Ser Tyr Gly Ser Gly Ser Ser Ser Gly Gly Tyr Arg Gly Gly Ser Gly
            580                 585                 590         
Gly Gly Gly Gly Gly Ser Ser Gly Gly Arg Gly Ser Gly Gly Gly Ser
        595                 600                 605             
Ser Gly Gly Ser Ile Gly Gly Arg Gly Ser Ser Ser Gly Gly Val Lys
    610                 615                 620                 
Ser Ser Gly Gly Ser Ser Ser Val Arg Phe Val Ser Thr Thr Tyr Ser
625                 630                 635                 640 
Gly Val Thr Arg
                


<210> 5999
<211> 1031
<212> PRT
<213> Homo sapiens

<400> 5999
Met Pro Pro Gly Arg Trp His Ala Ala Tyr Pro Ala Gln Ala Gln Ser
 1               5                  10                  15      
Ser Arg Glu Arg Gly Arg Leu Gln Thr Val Lys Lys Glu Glu Glu Asp
            20                  25                  30          
Glu Ser Tyr Thr Pro Val Gln Ala Ala Arg Pro Gln Thr Leu Asn Arg
        35                  40                  45              
Pro Gly Gln Glu Leu Phe Arg Gln Leu Phe Arg Gln Leu Arg Tyr His
    50                  55                  60                  
Glu Ser Ser Gly Pro Leu Glu Thr Leu Ser Arg Leu Arg Glu Leu Cys
65                  70                  75                  80  
Arg Trp Trp Leu Arg Pro Asp Val Leu Ser Lys Ala Gln Ile Leu Glu
                85                  90                  95      
Leu Leu Val Leu Glu Gln Phe Leu Ser Ile Leu Pro Gly Glu Leu Arg
            100                 105                 110         
Val Trp Val Gln Leu His Asn Pro Glu Ser Gly Glu Glu Ala Val Ala
        115                 120                 125             
Leu Leu Glu Glu Leu Gln Arg Asp Leu Asp Gly Thr Ser Trp Arg Asp
    130                 135                 140                 
Pro Gly Pro Ala Gln Ser Pro Asp Val His Trp Met Gly Thr Gly Ala
145                 150                 155                 160 
Leu Arg Ser Ala Gln Ile Trp Ser Leu Ala Ser Pro Leu Arg Ser Ser
                165                 170                 175     
Ser Ala Leu Gly Asp His Leu Glu Pro Pro Tyr Glu Ile Glu Ala Arg
            180                 185                 190         
Asp Phe Leu Ala Gly Gln Ser Asp Thr Pro Ala Ala Gln Met Pro Ala
        195                 200                 205             
Leu Phe Pro Arg Glu Gly Cys Pro Gly Asp Gln Val Thr Pro Thr Arg
    210                 215                 220                 
Ser Leu Thr Ala Gln Leu Gln Glu Thr Met Thr Phe Lys Asp Val Glu
225                 230                 235                 240 
Val Thr Phe Ser Gln Asp Glu Trp Gly Trp Leu Asp Ser Ala Gln Arg
                245                 250                 255     
Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Met Ala Ser
            260                 265                 270         
Leu Val Gly Pro Phe Thr Lys Pro Ala Leu Ile Ser Trp Leu Glu Ala
        275                 280                 285             
Arg Glu Pro Trp Gly Leu Asn Met Gln Ala Ala Gln Pro Lys Gly Asn
    290                 295                 300                 
Pro Val Ala Ala Pro Thr Gly Asp Asp Leu Gln Ser Lys Thr Asn Lys
305                 310                 315                 320 
Phe Ile Leu Asn Gln Glu Pro Leu Glu Glu Ala Glu Thr Leu Ala Val
                325                 330                 335     
Ser Ser Gly Cys Pro Ala Thr Ser Val Ser Glu Gly Ile Gly Leu Arg
            340                 345                 350         
Glu Ser Phe Gln Gln Lys Ser Arg Gln Lys Asp Gln Cys Glu Asn Pro
        355                 360                 365             
Ile Gln Val Arg Val Lys Lys Glu Glu Thr Asn Phe Ser His Arg Thr
    370                 375                 380                 
Gly Lys Asp Ser Glu Val Ser Gly Ser Asn Ser Leu Asp Leu Lys His
385                 390                 395                 400 
Val Thr Tyr Leu Arg Val Ser Gly Arg Lys Glu Ser Leu Lys His Gly
                405                 410                 415     
Cys Gly Lys His Phe Arg Met Ser Ser His His Tyr Asp Tyr Lys Lys
            420                 425                 430         
Tyr Gly Lys Gly Leu Arg His Met Ile Gly Gly Phe Ser Leu His Gln
        435                 440                 445             
Arg Ile His Ser Gly Leu Lys Gly Asn Lys Lys Asp Val Cys Gly Lys
    450                 455                 460                 
Asp Phe Ser Leu Ser Ser His His Gln Arg Gly Gln Ser Leu His Thr
465                 470                 475                 480 
Val Gly Val Ser Phe Lys Cys Ser Asp Cys Gly Arg Thr Phe Ser His
                485                 490                 495     
Ser Ser His Leu Ala Tyr His Gln Arg Leu His Thr Gln Glu Lys Ala
            500                 505                 510         
Phe Lys Cys Arg Val Cys Gly Lys Ala Phe Arg Trp Ser Ser Asn Cys
        515                 520                 525             
Ala Arg His Glu Lys Ile His Thr Gly Val Lys Pro Tyr Lys Cys Asp
    530                 535                 540                 
Leu Cys Glu Lys Ala Phe Arg Arg Leu Ser Ala Tyr Arg Leu His Arg
545                 550                 555                 560 
Glu Thr His Ala Lys Lys Lys Phe Leu Glu Leu Asn Gln Tyr Arg Ala
                565                 570                 575     
Ala Leu Thr Tyr Ser Ser Gly Phe Asp His His Leu Gly Asp Gln Ser
            580                 585                 590         
Gly Glu Lys Leu Phe Asp Cys Ser Gln Cys Arg Lys Ser Phe His Cys
        595                 600                 605             
Lys Ser Tyr Val Leu Glu His Gln Arg Ile His Thr Gln Glu Lys Pro
    610                 615                 620                 
Tyr Lys Cys Thr Lys Cys Arg Lys Thr Phe Arg Trp Arg Ser Asn Phe
625                 630                 635                 640 
Thr Arg His Met Arg Leu His Glu Glu Glu Lys Phe Tyr Lys Gln Asp
                645                 650                 655     
Glu Cys Arg Glu Gly Phe Arg Gln Ser Pro Asp Cys Ser Gln Pro Gln
            660                 665                 670         
Gly Ala Pro Ala Val Glu Lys Thr Phe Leu Cys Gln Gln Cys Gly Lys
        675                 680                 685             
Thr Phe Thr Arg Lys Lys Thr Leu Val Asp His Gln Arg Ile His Thr
    690                 695                 700                 
Gly Glu Lys Pro Tyr Gln Cys Ser Asp Cys Gly Lys Asp Phe Ala Tyr
705                 710                 715                 720 
Arg Ser Ala Phe Ile Val His Lys Lys Lys His Ala Met Lys Arg Lys
                725                 730                 735     
Pro Glu Gly Gly Pro Ser Phe Ser Gln Asp Thr Val Phe Gln Val Pro
            740                 745                 750         
Gln Ser Ser His Ser Lys Glu Glu Pro Tyr Lys Cys Ser Gln Cys Gly
        755                 760                 765             
Lys Ala Phe Arg Asn His Ser Phe Leu Leu Ile His Gln Arg Val His
    770                 775                 780                 
Thr Gly Glu Lys Pro Tyr Lys Cys Arg Glu Cys Gly Lys Ala Phe Arg
785                 790                 795                 800 
Trp Ser Ser Asn Leu Tyr Arg His Gln Arg Ile His Ser Leu Gln Lys
                805                 810                 815     
Gln Tyr Asp Cys His Glu Ser Glu Lys Thr Pro Asn Val Glu Pro Lys
            820                 825                 830         
Ile Leu Thr Gly Glu Lys Arg Phe Trp Cys Gln Glu Cys Gly Lys Thr
        835                 840                 845             
Phe Thr Arg Lys Arg Thr Leu Leu Asp His Lys Gly Ile His Ser Gly
    850                 855                 860                 
Glu Lys Arg Tyr Lys Cys Asn Leu Cys Gly Lys Ser Tyr Asp Arg Asn
865                 870                 875                 880 
Tyr Arg Leu Val Asn His Gln Arg Ile His Ser Thr Glu Arg Pro Phe
                885                 890                 895     
Lys Cys Gln Trp Cys Gly Lys Glu Phe Ile Gly Arg His Thr Leu Ser
            900                 905                 910         
Ser His Gln Arg Lys His Thr Arg Ala Ala Gln Ala Glu Arg Ser Pro
        915                 920                 925             
Pro Ala Arg Ser Ser Ser Gln Asp Thr Lys Leu Arg Leu Gln Lys Leu
    930                 935                 940                 
Lys Pro Ser Glu Glu Met Pro Leu Glu Asp Cys Lys Glu Ala Cys Ser
945                 950                 955                 960 
Gln Ser Ser Arg Leu Thr Gly Leu Gln Asp Ile Ser Ile Gly Lys Lys
                965                 970                 975     
Cys His Lys Cys Ser Ile Cys Gly Lys Thr Phe Asn Lys Ser Ser Gln
            980                 985                 990         
Leu Ile Ser His Lys Arg Phe His Thr Arg Glu Arg Pro Phe Lys Cys
        995                 1000                1005            
Ser Lys Cys Gly Lys Thr Phe Arg Trp Ser Ser Asn Leu Ala Arg His
    1010                1015                1020                
Met Lys Asn His Ile Arg Asp
1025                1030    


<210> 6000
<211> 1116
<212> PRT
<213> Homo sapiens

<400> 6000
Met Pro Asn Asn Leu Thr Asp Cys Glu Asp Gly Asp Gly Gly Ala Asn
 1               5                  10                  15      
Pro Gly Asp Gly Asn Pro Lys Glu Ser Ser Pro Phe Ile Asn Ser Thr
            20                  25                  30          
Asp Thr Glu Lys Gly Lys Glu Tyr Asp Gly Lys Asn Met Ala Leu Phe
        35                  40                  45              
Glu Glu Glu Met Asp Thr Ser Pro Met Val Ser Ser Leu Leu Ser Gly
    50                  55                  60                  
Leu Ala Asn Tyr Thr Asn Leu Pro Gln Gly Ser Arg Glu His Glu Glu
65                  70                  75                  80  
Ala Glu Asn Asn Glu Gly Gly Lys Lys Lys Pro Val Gln Ala Pro Arg
                85                  90                  95      
Met Gly Thr Phe Met Gly Val Tyr Leu Pro Cys Leu Gln Asn Ile Phe
            100                 105                 110         
Gly Val Ile Leu Phe Leu Arg Leu Thr Trp Val Val Gly Ile Ala Gly
        115                 120                 125             
Ile Met Glu Ser Phe Cys Met Val Phe Ile Cys Cys Ser Cys Thr Met
    130                 135                 140                 
Leu Thr Ala Ile Ser Met Ser Ala Ile Ala Thr Asn Gly Val Val Pro
145                 150                 155                 160 
Ala Gly Gly Ser Tyr Tyr Met Ile Ser Arg Ser Leu Gly Pro Glu Phe
                165                 170                 175     
Gly Gly Ala Val Gly Leu Cys Phe Tyr Leu Gly Thr Thr Phe Ala Gly
            180                 185                 190         
Ala Met Tyr Ile Leu Gly Thr Ile Glu Ile Leu Leu Ala Tyr Leu Phe
        195                 200                 205             
Pro Ala Met Ala Ile Phe Lys Ala Glu Asp Ala Ser Gly Glu Ala Ala
    210                 215                 220                 
Ala Met Leu Asn Asn Met Arg Val Tyr Gly Thr Cys Val Leu Thr Cys
225                 230                 235                 240 
Met Ala Thr Val Val Phe Val Gly Val Lys Tyr Val Asn Lys Phe Ala
                245                 250                 255     
Leu Val Phe Leu Gly Cys Val Ile Leu Ser Ile Leu Ala Ile Tyr Ala
            260                 265                 270         
Gly Val Ile Lys Ser Ala Phe Asp Pro Pro Asn Phe Pro Ile Cys Leu
        275                 280                 285             
Leu Gly Asn Arg Thr Leu Ser Arg His Gly Phe Asp Val Cys Ala Lys
    290                 295                 300                 
Leu Ala Trp Glu Gly Asn Glu Thr Val Thr Thr Arg Leu Trp Gly Leu
305                 310                 315                 320 
Phe Cys Ser Ser Arg Phe Leu Asn Ala Thr Cys Asp Glu Tyr Phe Thr
                325                 330                 335     
Arg Asn Asn Val Thr Glu Ile Gln Gly Ile Pro Gly Ala Ala Ser Gly
            340                 345                 350         
Leu Ile Lys Glu Asn Leu Trp Ser Ser Tyr Leu Thr Lys Gly Val Ile
        355                 360                 365             
Val Glu Arg Ser Gly Met Thr Ser Val Gly Leu Ala Asp Gly Thr Pro
    370                 375                 380                 
Ile Asp Met Asp His Pro Tyr Val Phe Ser Asp Met Thr Ser Tyr Phe
385                 390                 395                 400 
Thr Leu Leu Val Gly Ile Tyr Phe Pro Ser Val Thr Gly Ile Met Ala
                405                 410                 415     
Gly Ser Asn Arg Ser Gly Asp Leu Arg Asp Ala Gln Lys Ser Ile Pro
            420                 425                 430         
Thr Gly Thr Ile Leu Ala Ile Ala Thr Thr Ser Ala Val Tyr Ile Ser
        435                 440                 445             
Ser Val Val Leu Phe Gly Ala Cys Ile Glu Gly Val Val Leu Arg Asp
    450                 455                 460                 
Lys Phe Gly Glu Ala Val Asn Gly Asn Leu Val Val Gly Thr Leu Ala
465                 470                 475                 480 
Trp Pro Ser Pro Trp Val Ile Val Ile Gly Ser Phe Phe Ser Thr Cys
                485                 490                 495     
Gly Ala Gly Leu Gln Ser Leu Thr Gly Ala Pro Arg Leu Leu Gln Ala
            500                 505                 510         
Ile Ser Arg Asp Gly Ile Val Pro Phe Leu Gln Val Phe Gly His Gly
        515                 520                 525             
Lys Ala Asn Gly Glu Pro Thr Trp Ala Leu Leu Leu Thr Ala Cys Ile
    530                 535                 540                 
Cys Glu Ile Gly Ile Leu Ile Ala Ser Leu Asp Glu Val Ala Pro Ile
545                 550                 555                 560 
Leu Ser Met Phe Phe Leu Met Cys Tyr Met Phe Val Asn Leu Ala Cys
                565                 570                 575     
Ala Val Gln Thr Leu Leu Arg Thr Pro Asn Trp Arg Pro Arg Phe Arg
            580                 585                 590         
Tyr Tyr His Trp Thr Leu Ser Phe Leu Gly Met Ser Leu Cys Leu Ala
        595                 600                 605             
Leu Met Phe Ile Cys Ser Trp Tyr Tyr Ala Leu Val Ala Met Leu Ile
    610                 615                 620                 
Ala Gly Leu Ile Tyr Lys Tyr Ile Glu Tyr Arg Gly Ala Glu Lys Glu
625                 630                 635                 640 
Trp Gly Asp Gly Ile Arg Gly Leu Ser Leu Ser Ala Ala Arg Tyr Ala
                645                 650                 655     
Leu Leu Arg Leu Glu Glu Gly Pro Pro His Thr Lys Asn Trp Arg Pro
            660                 665                 670         
Gln Leu Leu Val Leu Val Arg Val Asp Gln Asp Gln Asn Val Val His
        675                 680                 685             
Pro Gln Leu Leu Ser Leu Thr Ser Gln Leu Lys Ala Gly Lys Gly Leu
    690                 695                 700                 
Thr Ile Val Gly Ser Val Leu Glu Gly Thr Phe Leu Glu Asn His Pro
705                 710                 715                 720 
Gln Ala Gln Arg Ala Glu Glu Ser Ile Arg Arg Leu Met Glu Ala Glu
                725                 730                 735     
Lys Val Lys Gly Phe Cys Gln Val Val Ile Ser Ser Asn Leu Arg Asp
            740                 745                 750         
Gly Val Ser His Leu Ile Gln Ser Gly Gly Leu Gly Gly Leu Gln His
        755                 760                 765             
Asn Thr Val Leu Val Gly Trp Pro Arg Asn Trp Arg Gln Lys Glu Asp
    770                 775                 780                 
His Gln Thr Trp Arg Asn Phe Ile Glu Leu Val Arg Glu Thr Thr Ala
785                 790                 795                 800 
Gly His Leu Ala Leu Leu Val Thr Lys Asn Val Ser Met Phe Pro Gly
                805                 810                 815     
Asn Pro Glu Arg Phe Ser Glu Gly Ser Ile Asp Val Trp Trp Ile Val
            820                 825                 830         
His Asp Gly Gly Met Leu Met Leu Leu Pro Phe Leu Leu Arg His His
        835                 840                 845             
Lys Val Trp Arg Lys Cys Lys Met Arg Ile Phe Thr Val Ala Gln Met
    850                 855                 860                 
Asp Asp Asn Ser Ile Gln Met Lys Lys Asp Leu Thr Thr Phe Leu Tyr
865                 870                 875                 880 
His Leu Arg Ile Thr Ala Glu Val Glu Val Val Glu Met His Glu Ser
                885                 890                 895     
Asp Ile Ser Ala Tyr Thr Tyr Glu Lys Thr Leu Val Met Glu Gln Arg
            900                 905                 910         
Ser Gln Ile Leu Lys Gln Met His Leu Thr Lys Asn Glu Arg Glu Arg
        915                 920                 925             
Glu Ile Gln Ser Ile Thr Asp Glu Ser Arg Gly Ser Ile Arg Arg Lys
    930                 935                 940                 
Asn Pro Ala Asn Thr Arg Leu Arg Leu Asn Val Pro Glu Glu Thr Ala
945                 950                 955                 960 
Gly Asp Ser Glu Glu Lys Pro Glu Glu Glu Val Gln Leu Ile His Asp
                965                 970                 975     
Gln Ser Ala Pro Ser Cys Pro Ser Ser Ser Pro Ser Pro Gly Glu Glu
            980                 985                 990         
Pro Glu Gly Glu Gly Glu Thr Asp Pro Glu Lys Val His Leu Thr Trp
        995                 1000                1005            
Thr Lys Asp Lys Ser Val Ala Glu Lys Asn Lys Gly Pro Ser Pro Val
    1010                1015                1020                
Ser Ser Glu Gly Ile Lys Asp Phe Phe Ser Met Lys Pro Glu Trp Glu
1025                1030                1035                1040
Asn Leu Asn Gln Ser Asn Val Arg Arg Met His Thr Ala Val Arg Leu
                1045                1050                1055    
Asn Glu Val Ile Val Lys Lys Ser Arg Asp Ala Lys Leu Val Leu Leu
            1060                1065                1070        
Asn Met Pro Gly Pro Pro Arg Asn Arg Asn Gly Asp Glu Asn Tyr Met
        1075                1080                1085            
Glu Phe Leu Glu Val Leu Thr Glu His Leu Asp Arg Val Met Leu Val
    1090                1095                1100                
Arg Gly Gly Gly Arg Glu Val Ile Thr Ile Tyr Ser
1105                1110                1115    


<210> 6001
<211> 894
<212> PRT
<213> Homo sapiens

<400> 6001
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys
 1               5                  10                  15      
Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala
            20                  25                  30          
Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg
        35                  40                  45              
Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro
    50                  55                  60                  
Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp
65                  70                  75                  80  
Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp
                85                  90                  95      
Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr
            100                 105                 110         
Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser
        115                 120                 125             
Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu
    130                 135                 140                 
Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys
145                 150                 155                 160 
Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp
                165                 170                 175     
Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu
            180                 185                 190         
His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His
        195                 200                 205             
Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu
    210                 215                 220                 
Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu
225                 230                 235                 240 
Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr
                245                 250                 255     
His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln
            260                 265                 270         
Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser
        275                 280                 285             
Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro
    290                 295                 300                 
Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp
305                 310                 315                 320 
Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro
                325                 330                 335     
Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His
            340                 345                 350         
Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg
        355                 360                 365             
Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly
    370                 375                 380                 
Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser
385                 390                 395                 400 
Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro
                405                 410                 415     
Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln
            420                 425                 430         
Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp
        435                 440                 445             
Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val
    450                 455                 460                 
Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg
465                 470                 475                 480 
Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val
                485                 490                 495     
Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr
            500                 505                 510         
Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp
        515                 520                 525             
Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu
    530                 535                 540                 
Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser
545                 550                 555                 560 
Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg
                565                 570                 575     
Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe
            580                 585                 590         
Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser
        595                 600                 605             
Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys
    610                 615                 620                 
His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln
625                 630                 635                 640 
Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile
                645                 650                 655     
Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp
            660                 665                 670         
Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val
        675                 680                 685             
Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg
    690                 695                 700                 
Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser
705                 710                 715                 720 
Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly
                725                 730                 735     
Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly
            740                 745                 750         
Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Arg Gly Asn Arg Leu
        755                 760                 765             
Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg
    770                 775                 780                 
Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg
785                 790                 795                 800 
Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro
                805                 810                 815     
Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu
            820                 825                 830         
Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro
        835                 840                 845             
Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly
    850                 855                 860                 
Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala
865                 870                 875                 880 
Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala
                885                 890                 


<210> 6002
<211> 885
<212> PRT
<213> Homo sapiens

<400> 6002
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys
 1               5                  10                  15      
Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala
            20                  25                  30          
Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg
        35                  40                  45              
Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro
    50                  55                  60                  
Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp
65                  70                  75                  80  
Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp
                85                  90                  95      
Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr
            100                 105                 110         
Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser
        115                 120                 125             
Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu
    130                 135                 140                 
Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys
145                 150                 155                 160 
Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp
                165                 170                 175     
Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu
            180                 185                 190         
His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His
        195                 200                 205             
Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu
    210                 215                 220                 
Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu
225                 230                 235                 240 
Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr
                245                 250                 255     
His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln
            260                 265                 270         
Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser
        275                 280                 285             
Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro
    290                 295                 300                 
Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp
305                 310                 315                 320 
Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro
                325                 330                 335     
Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His
            340                 345                 350         
Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg
        355                 360                 365             
Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly
    370                 375                 380                 
Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser
385                 390                 395                 400 
Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro
                405                 410                 415     
Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro
            420                 425                 430         
Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala
        435                 440                 445             
Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His
    450                 455                 460                 
Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val
465                 470                 475                 480 
Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser
                485                 490                 495     
Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu
            500                 505                 510         
Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala
        515                 520                 525             
Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly
    530                 535                 540                 
Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met
545                 550                 555                 560 
Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu
                565                 570                 575     
Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile
            580                 585                 590         
Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val
        595                 600                 605             
Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu
    610                 615                 620                 
Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu
625                 630                 635                 640 
Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr
                645                 650                 655     
Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn
            660                 665                 670         
Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile
        675                 680                 685             
Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val
    690                 695                 700                 
Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys
705                 710                 715                 720 
Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg
                725                 730                 735     
Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr
            740                 745                 750         
Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly
        755                 760                 765             
Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg
    770                 775                 780                 
Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala
785                 790                 795                 800 
Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp
                805                 810                 815     
Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp
            820                 825                 830         
Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala
        835                 840                 845             
Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr
    850                 855                 860                 
Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly
865                 870                 875                 880 
Gln Glu Asp Gly Ala
                885 


<210> 6003
<211> 415
<212> PRT
<213> Homo sapiens

<400> 6003
Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu
 1               5                  10                  15      
Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu
            20                  25                  30          
Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe
        35                  40                  45              
Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg
    50                  55                  60                  
Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg
65                  70                  75                  80  
Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile
                85                  90                  95      
Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu
            100                 105                 110         
Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr
        115                 120                 125             
Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser
    130                 135                 140                 
His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro
145                 150                 155                 160 
Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe
                165                 170                 175     
Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val
            180                 185                 190         
Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro
        195                 200                 205             
Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu
    210                 215                 220                 
Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu
225                 230                 235                 240 
Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val
                245                 250                 255     
Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys
            260                 265                 270         
Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr
        275                 280                 285             
Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp
    290                 295                 300                 
Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro
305                 310                 315                 320 
Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro
                325                 330                 335     
Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln
            340                 345                 350         
Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu
        355                 360                 365             
Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro
    370                 375                 380                 
Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe
385                 390                 395                 400 
Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys
                405                 410                 415 


<210> 6004
<211> 312
<212> PRT
<213> Homo sapiens

<400> 6004
Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala
 1               5                  10                  15      
Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu
            20                  25                  30          
Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly
        35                  40                  45              
Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro
    50                  55                  60                  
Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro
65                  70                  75                  80  
Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val
                85                  90                  95      
Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Ala Arg
            100                 105                 110         
Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly
        115                 120                 125             
Ala Ala Leu Ala Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly
    130                 135                 140                 
Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg Gln Leu Ala Leu Arg
145                 150                 155                 160 
Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg
                165                 170                 175     
Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala
            180                 185                 190         
Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro
        195                 200                 205             
Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys
    210                 215                 220                 
Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu
225                 230                 235                 240 
Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro
                245                 250                 255     
Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro
            260                 265                 270         
Val Asn Asp Leu Asn Ala Gly Leu Ser Gln Phe Leu Leu Gln Ser Ser
        275                 280                 285             
Ser Ser Leu Val Met Gln Arg Leu Phe Phe His Cys Phe Leu Ser Trp
    290                 295                 300                 
Ala Thr Ser Lys Thr Arg Asn Pro
305                 310         


<210> 6005
<211> 487
<212> PRT
<213> Homo sapiens

<400> 6005
Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala
 1               5                  10                  15      
Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu
            20                  25                  30          
Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly
        35                  40                  45              
Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro
    50                  55                  60                  
Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro
65                  70                  75                  80  
Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val
                85                  90                  95      
Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Ala Arg
            100                 105                 110         
Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly
        115                 120                 125             
Ala Ala Leu Ala Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly
    130                 135                 140                 
Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg Gln Leu Ala Leu Arg
145                 150                 155                 160 
Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg
                165                 170                 175     
Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala
            180                 185                 190         
Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro
        195                 200                 205             
Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys
    210                 215                 220                 
Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu
225                 230                 235                 240 
Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro
                245                 250                 255     
Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro
            260                 265                 270         
Val Asn Asp Leu Asn Ala Asp Leu Ile Gln Val Ala Phe Phe Thr Cys
        275                 280                 285             
Ser Phe Asp Leu Ala Ile Lys Gly Val Lys Ser Pro Trp Cys Asp Val
    290                 295                 300                 
Phe Asp Ile Asp Asp Ala Lys Val Leu Glu Tyr Leu Asn Asp Leu Lys
305                 310                 315                 320 
Gln Tyr Trp Lys Arg Gly Tyr Gly Tyr Thr Ile Asn Ser Arg Ser Ser
                325                 330                 335     
Cys Thr Leu Phe Gln Asp Ile Phe Gln His Leu Asp Lys Ala Val Glu
            340                 345                 350         
Gln Lys Gln Arg Ser Gln Pro Ile Ser Ser Pro Val Ile Leu Gln Phe
        355                 360                 365             
Gly His Ala Glu Thr Leu Leu Pro Leu Leu Ser Leu Met Gly Tyr Phe
    370                 375                 380                 
Lys Asp Lys Glu Pro Leu Thr Ala Tyr Asn Tyr Lys Lys Gln Met His
385                 390                 395                 400 
Arg Lys Phe Arg Ser Gly Leu Ile Val Pro Tyr Ala Ser Asn Leu Ile
                405                 410                 415     
Phe Val Leu Tyr His Cys Glu Asn Ala Lys Thr Pro Lys Glu Gln Phe
            420                 425                 430         
Arg Val Gln Met Leu Leu Asn Glu Lys Val Leu Pro Leu Ala Tyr Ser
        435                 440                 445             
Gln Glu Thr Val Ser Phe Tyr Glu Asp Leu Lys Asn His Tyr Lys Asp
    450                 455                 460                 
Ile Leu Gln Ser Cys Gln Thr Ser Glu Glu Cys Glu Leu Ala Arg Ala
465                 470                 475                 480 
Asn Ser Thr Ser Asp Glu Leu
                485         


<210> 6006
<211> 487
<212> PRT
<213> Homo sapiens

<400> 6006
Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala
 1               5                  10                  15      
Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu
            20                  25                  30          
Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly
        35                  40                  45              
Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro
    50                  55                  60                  
Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro
65                  70                  75                  80  
Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val
                85                  90                  95      
Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Pro Arg
            100                 105                 110         
Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly
        115                 120                 125             
Ala Ala Leu Arg Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly
    130                 135                 140                 
Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg His Val Ala Leu Arg
145                 150                 155                 160 
Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg
                165                 170                 175     
Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala
            180                 185                 190         
Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro
        195                 200                 205             
Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys
    210                 215                 220                 
Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu
225                 230                 235                 240 
Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro
                245                 250                 255     
Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro
            260                 265                 270         
Val Asn Asp Leu Asn Ala Asp Leu Ile Gln Val Ala Phe Phe Thr Cys
        275                 280                 285             
Ser Phe Asp Leu Ala Ile Lys Gly Val Lys Ser Pro Trp Cys Asp Val
    290                 295                 300                 
Phe Asp Ile Asp Asp Ala Lys Val Leu Glu Tyr Leu Asn Asp Leu Lys
305                 310                 315                 320 
Gln Tyr Trp Lys Arg Gly Tyr Gly Tyr Thr Ile Asn Ser Arg Ser Ser
                325                 330                 335     
Cys Thr Leu Phe Gln Asp Ile Phe Gln His Leu Asp Lys Ala Val Glu
            340                 345                 350         
Gln Lys Gln Arg Ser Gln Pro Ile Ser Ser Pro Val Ile Leu Gln Phe
        355                 360                 365             
Gly His Ala Glu Thr Leu Leu Pro Leu Leu Ser Leu Met Gly Tyr Phe
    370                 375                 380                 
Lys Asp Lys Glu Pro Leu Thr Ala Tyr Asn Tyr Lys Lys Gln Met His
385                 390                 395                 400 
Arg Lys Phe Arg Ser Gly Leu Ile Val Pro Tyr Ala Ser Asn Leu Ile
                405                 410                 415     
Phe Val Leu Tyr His Cys Glu Asn Ala Lys Thr Pro Lys Glu Gln Phe
            420                 425                 430         
Arg Val Gln Met Leu Leu Asn Glu Lys Val Leu Pro Leu Ala Tyr Ser
        435                 440                 445             
Gln Glu Thr Val Ser Phe Tyr Glu Asp Leu Lys Asn His Tyr Lys Asp
    450                 455                 460                 
Ile Leu Gln Ser Cys Gln Thr Ser Glu Glu Cys Glu Leu Ala Arg Ala
465                 470                 475                 480 
Asn Ser Thr Ser Asp Glu Leu
                485         


<210> 6007
<211> 1807
<212> PRT
<213> Homo sapiens

<400> 6007
Met Ser Asp Thr Lys Val Lys Val Ala Val Arg Val Arg Pro Met Asn
 1               5                  10                  15      
Arg Arg Glu Leu Glu Leu Asn Thr Lys Cys Val Val Glu Met Glu Gly
            20                  25                  30          
Asn Gln Thr Val Leu His Pro Pro Pro Ser Asn Thr Lys Gln Gly Glu
        35                  40                  45              
Ser Leu Ile Phe Cys Ser Phe Ile Gln Val Phe Ala Phe Asp Tyr Cys
    50                  55                  60                  
Phe Trp Ser Met Asp Glu Ser Asn Thr Thr Lys Tyr Ala Gly Gln Glu
65                  70                  75                  80  
Val Val Phe Lys Cys Leu Gly Glu Gly Ile Leu Glu Lys Ala Phe Gln
                85                  90                  95      
Gly Tyr Asn Ala Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys
            100                 105                 110         
Ser Phe Ser Met Met Gly His Ala Glu Gln Leu Gly Leu Ile Pro Arg
        115                 120                 125             
Leu Cys Cys Ala Leu Phe Lys Arg Ile Ser Leu Glu Gln Asn Glu Ser
    130                 135                 140                 
Gln Thr Phe Lys Val Glu Val Ser Tyr Met Glu Ile Tyr Asn Glu Lys
145                 150                 155                 160 
Val Arg Asp Leu Leu Asp Pro Lys Gly Ser Arg Gln Ser Leu Lys Val
                165                 170                 175     
Arg Glu His Lys Val Leu Gly Pro Tyr Val Asp Gly Leu Ser Gln Leu
            180                 185                 190         
Ala Val Thr Ser Phe Glu Asp Ile Glu Ser Leu Met Ser Glu Gly Asn
        195                 200                 205             
Lys Ser Arg Thr Val Ala Ala Thr Asn Met Asn Glu Glu Ser Ser Arg
    210                 215                 220                 
Ser His Ala Val Phe Asn Ile Ile Ile Thr Gln Thr Leu Tyr Asp Leu
225                 230                 235                 240 
Gln Ser Gly Asn Ser Gly Glu Lys Val Ser Lys Val Ser Leu Val Asp
                245                 250                 255     
Leu Ala Gly Ser Glu Arg Val Ser Lys Thr Gly Ala Ala Gly Glu Arg
            260                 265                 270         
Leu Lys Glu Gly Ser Asn Ile Asn Lys Ser Leu Thr Thr Leu Gly Leu
        275                 280                 285             
Val Ile Ser Ser Leu Ala Asp Gln Ala Ala Gly Lys Gly Lys Ser Lys
    290                 295                 300                 
Phe Val Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Asn
305                 310                 315                 320 
Leu Gly Gly Asn Ser Gln Thr Ser Met Ile Ala Thr Ile Ser Pro Ala
                325                 330                 335     
Ala Asp Asn Tyr Glu Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg
            340                 345                 350         
Ala Lys Arg Ile Val Asn His Ala Val Val Asn Glu Asp Pro Asn Ala
        355                 360                 365             
Lys Val Ile Arg Glu Leu Arg Glu Glu Val Glu Lys Leu Arg Glu Gln
    370                 375                 380                 
Leu Ser Gln Ala Glu Ala Met Lys Ala Pro Glu Leu Lys Glu Lys Leu
385                 390                 395                 400 
Glu Glu Ser Glu Lys Leu Ile Lys Glu Leu Thr Val Thr Trp Glu Glu
                405                 410                 415     
Lys Leu Arg Lys Thr Glu Glu Ile Ala Gln Glu Arg Gln Arg Gln Leu
            420                 425                 430         
Glu Ser Met Gly Ile Ser Leu Glu Met Ser Gly Ile Lys Val Gly Asp
        435                 440                 445             
Asp Lys Cys Tyr Leu Val Asn Leu Asn Ala Asp Pro Ala Leu Asn Glu
    450                 455                 460                 
Leu Leu Val Tyr Tyr Leu Lys Asp His Thr Arg Val Gly Ala Asp Thr
465                 470                 475                 480 
Ser Gln Asp Ile Gln Leu Phe Gly Ile Gly Ile Gln Pro Gln His Cys
                485                 490                 495     
Glu Ile Asp Ile Ala Ser Asp Gly Asp Val Thr Leu Thr Pro Lys Glu
            500                 505                 510         
Asn Ala Arg Ser Cys Val Asn Gly Thr Leu Val Cys Ser Thr Thr Gln
        515                 520                 525             
Leu Trp His Gly Asp Arg Ile Leu Trp Gly Asn Asn His Phe Phe Arg
    530                 535                 540                 
Ile Asn Leu Pro Lys Arg Lys Arg Arg Asp Trp Leu Lys Asp Phe Glu
545                 550                 555                 560 
Lys Glu Thr Gly Pro Pro Glu His Asp Leu Asp Ala Ala Ser Glu Ala
                565                 570                 575     
Ser Ser Glu Pro Asp Tyr Asn Tyr Glu Phe Ala Gln Met Glu Val Ile
            580                 585                 590         
Met Lys Thr Leu Asn Ser Asn Asp Pro Val Gln Asn Val Val Gln Val
        595                 600                 605             
Leu Glu Lys Gln Tyr Leu Glu Glu Lys Arg Ser Ala Leu Glu Glu Gln
    610                 615                 620                 
Arg Leu Met Tyr Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser
625                 630                 635                 640 
Pro Asp Arg Gln Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser
                645                 650                 655     
Ser Gln Thr Ala Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp
            660                 665                 670         
Glu Leu Phe Arg Gln Ser Leu Ala Lys Leu Arg Glu Gln Leu Val Lys
        675                 680                 685             
Ala Asn Thr Leu Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser
    690                 695                 700                 
Lys Leu Thr Asp Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu
705                 710                 715                 720 
Ser Ala Asn Arg Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln
                725                 730                 735     
Val Arg Arg Lys Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu
            740                 745                 750         
Glu Asn Lys Leu Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu
        755                 760                 765             
Lys Val Pro Glu Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe
    770                 775                 780                 
Tyr Glu Ala Gln Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe
785                 790                 795                 800 
Leu Glu Cys Leu Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile
                805                 810                 815     
Ile Ser Gln Gln Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met
            820                 825                 830         
Arg Val Thr Gly Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser
        835                 840                 845             
Glu Asn Ser Ser Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly
    850                 855                 860                 
Glu Ile Ile His Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys
865                 870                 875                 880 
Glu Ala Thr Gly Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln
                885                 890                 895     
Tyr Thr Phe Trp Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val
            900                 905                 910         
Asp Pro Glu Val Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val
        915                 920                 925             
Thr Phe Ser His Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe
    930                 935                 940                 
Leu Glu Phe Ile Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His
945                 950                 955                 960 
Arg Cys Ala Gly Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His
                965                 970                 975     
Ala Lys Thr Arg Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg
            980                 985                 990         
Ile Glu Met Trp Ile Ser Ile Leu Glu Leu Asn Glu Leu Gly Glu Tyr
        995                 1000                1005            
Ala Ala Val Glu Leu His Gln Ala Lys Asp Val Asn Thr Gly Gly Ile
    1010                1015                1020                
Phe Gln Leu Arg Gln Gly His Ser Arg Arg Val Gln Val Thr Val Lys
1025                1030                1035                1040
Pro Val Gln His Ser Gly Thr Leu Pro Leu Met Val Glu Ala Ile Leu
                1045                1050                1055    
Ser Val Ser Ile Gly Cys Val Thr Ala Arg Ser Thr Lys Leu Gln Arg
            1060                1065                1070        
Gly Leu Asp Ser Tyr Gln Arg Asp Asp Glu Asp Gly Asp Asp Met Asp
        1075                1080                1085            
Ser Tyr Gln Glu Glu Asp Leu Asn Cys Val Arg Glu Arg Trp Ser Asp
    1090                1095                1100                
Ala Leu Ile Lys Arg Arg Glu Tyr Leu Asp Glu Gln Ile Lys Lys Val
1105                1110                1115                1120
Ser Asn Lys Thr Glu Lys Thr Glu Asp Asp Val Glu Arg Glu Ala Gln
                1125                1130                1135    
Leu Val Glu Gln Trp Val Gly Leu Thr Glu Glu Arg Asn Ala Val Leu
            1140                1145                1150        
Val Pro Ala Pro Gly Ser Gly Ile Pro Gly Ala Pro Ala Asp Trp Ile
        1155                1160                1165            
Pro Pro Pro Gly Met Glu Thr His Ile Pro Val Leu Phe Leu Asp Leu
    1170                1175                1180                
Asn Ala Asp Asp Leu Ser Ala Asn Glu Gln Leu Val Gly Pro His Ala
1185                1190                1195                1200
Ser Gly Val Asn Ser Ile Leu Pro Lys Glu His Gly Ser Gln Phe Phe
                1205                1210                1215    
Tyr Leu Pro Ile Ile Lys His Ser Asp Asp Glu Val Ser Ala Thr Ala
            1220                1225                1230        
Ser Trp Asp Ser Ser Val His Asp Ser Val His Leu Asn Arg Val Thr
        1235                1240                1245            
Pro Gln Asn Glu Arg Ile Tyr Leu Ile Val Lys Thr Thr Val Gln Leu
    1250                1255                1260                
Ser His Pro Ala Ala Met Glu Leu Val Leu Arg Lys Arg Ile Ala Ala
1265                1270                1275                1280
Asn Ile Tyr Asn Lys Gln Ser Phe Thr Gln Ser Leu Lys Arg Arg Ile
                1285                1290                1295    
Ser Leu Lys Asn Ile Phe Tyr Ser Cys Gly Val Thr Tyr Glu Ile Val
            1300                1305                1310        
Ser Asn Ile Pro Lys Ala Thr Glu Glu Ile Glu Asp Arg Glu Thr Leu
        1315                1320                1325            
Ala Leu Leu Ala Ala Arg Ser Glu Asn Glu Gly Thr Ser Asp Gly Glu
    1330                1335                1340                
Thr Tyr Ile Glu Lys Tyr Thr Arg Gly Val Leu Gln Val Glu Asn Ile
1345                1350                1355                1360
Leu Ser Leu Glu Arg Leu Arg Gln Ala Ile Lys Glu Ala Leu Ser Thr
                1365                1370                1375    
Lys Ala Arg His Ile Arg Arg Ser Leu Ser Thr Pro Asn Val His Asn
            1380                1385                1390        
Val Ser Ser Ser Arg Pro Asp Leu Ser Gly Phe Asp Glu Asp Asp Lys
        1395                1400                1405            
Gly Trp Pro Glu Asn Gln Leu Asp Met Ser Asp Tyr Ser Ser Ser Tyr
    1410                1415                1420                
Gln Asp Val Ala Cys Tyr Gly Thr Leu Pro Arg Asp Ser Pro Arg Arg
1425                1430                1435                1440
Asn Lys Glu Gly Cys Thr Ser Glu Thr Pro His Ala Leu Thr Val Ser
                1445                1450                1455    
Pro Phe Lys Ala Phe Ser Pro Gln Pro Pro Lys Phe Phe Lys Pro Leu
            1460                1465                1470        
Met Pro Val Lys Glu Glu His Lys Lys Arg Ile Ala Leu Glu Ala Arg
        1475                1480                1485            
Pro Leu Leu Ser Gln Glu Ser Met Pro Pro Pro Gln Ala His Asn Pro
    1490                1495                1500                
Gly Cys Ile Val Pro Ser Gly Ser Asn Gly Ser Ser Met Pro Val Glu
1505                1510                1515                1520
His Asn Ser Lys Arg Glu Lys Lys Ile Asp Ser Glu Glu Glu Glu Asn
                1525                1530                1535    
Glu Leu Glu Ala Ile Asn Arg Lys Leu Ile Ser Ser Gln Pro Tyr Val
            1540                1545                1550        
Pro Val Glu Phe Ala Asp Phe Ser Val Tyr Asn Ala Ser Leu Glu Asn
        1555                1560                1565            
Arg Glu Trp Phe Ser Ser Lys Val Asp Leu Ser Asn Ser Arg Val Leu
    1570                1575                1580                
Glu Lys Glu Val Ser Arg Ser Pro Thr Thr Ser Ser Ile Thr Ser Gly
1585                1590                1595                1600
Tyr Phe Ser His Ser Ala Ser Asn Ala Thr Leu Ser Asp Met Val Val
                1605                1610                1615    
Pro Ser Ser Asp Ser Ser Asp Gln Leu Ala Ile Gln Thr Lys Asp Ala
            1620                1625                1630        
Asp Ser Thr Glu His Ser Thr Pro Ser Leu Val His Asp Phe Arg Pro
        1635                1640                1645            
Ser Ser Asn Lys Glu Leu Thr Glu Val Glu Lys Gly Leu Val Lys Asp
    1650                1655                1660                
Lys Ile Ile Val Val Pro Leu Lys Glu Asn Ser Ala Leu Ala Lys Gly
1665                1670                1675                1680
Ser Pro Ser Ser Gln Ser Ile Pro Glu Lys Asn Ser Lys Ser Leu Cys
                1685                1690                1695    
Arg Thr Gly Ser Cys Ser Glu Leu Asp Ala Cys Pro Ser Lys Ile Ser
            1700                1705                1710        
Gln Pro Ala Arg Gly Phe Cys Pro Arg Glu Val Thr Val Glu His Thr
        1715                1720                1725            
Thr Asn Ile Leu Glu Asp His Ser Phe Thr Glu Phe Met Gly Val Ser
    1730                1735                1740                
Glu Gly Lys Asp Phe Asp Gly Leu Thr Asp Ser Ser Ala Gly Glu Leu
1745                1750                1755                1760
Ser Ser Arg Arg Ser Leu Pro Asn Lys Thr Gly Gly Lys Thr Val Ser
                1765                1770                1775    
Asp Gly Leu His His Pro Ser Gln Leu His Ser Lys Leu Glu Asn Asp
            1780                1785                1790        
Gln Val Ile Ile Pro Glu Ala Ala Phe Trp Val Leu Cys Cys Gln
        1795                1800                1805        


<210> 6008
<211> 1749
<212> PRT
<213> Homo sapiens

<400> 6008
Met Ser Asp Thr Lys Val Lys Val Ala Val Arg Val Arg Pro Met Asn
 1               5                  10                  15      
Arg Arg Glu Leu Glu Leu Asn Thr Lys Cys Val Val Glu Met Glu Gly
            20                  25                  30          
Asn Gln Thr Val Leu His Pro Pro Pro Ser Asn Thr Lys Gln Gly Glu
        35                  40                  45              
Arg Lys Pro Pro Lys Val Phe Ala Phe Asp Tyr Cys Phe Trp Ser Met
    50                  55                  60                  
Asp Glu Ser Asn Thr Thr Lys Tyr Ala Gly Gln Glu Val Val Phe Lys
65                  70                  75                  80  
Cys Leu Gly Glu Gly Ile Leu Glu Lys Ala Phe Gln Gly Tyr Asn Ala
                85                  90                  95      
Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Phe Ser Met
            100                 105                 110         
Met Gly His Ala Glu Gln Leu Gly Leu Ile Pro Arg Leu Cys Cys Ala
        115                 120                 125             
Leu Phe Lys Arg Ile Ser Leu Glu Gln Asn Glu Ser Gln Thr Phe Lys
    130                 135                 140                 
Val Glu Val Ser Tyr Met Glu Ile Tyr Asn Glu Lys Val Arg Asp Leu
145                 150                 155                 160 
Leu Asp Pro Lys Gly Ser Arg Gln Ser Leu Lys Val Arg Glu His Lys
                165                 170                 175     
Val Leu Gly Pro Tyr Val Asp Gly Leu Ser Gln Leu Ala Val Thr Ser
            180                 185                 190         
Phe Glu Asp Ile Glu Ser Leu Met Ser Glu Gly Asn Lys Ser Arg Thr
        195                 200                 205             
Val Ala Ala Thr Asn Met Asn Glu Glu Ser Ser Arg Ser His Ala Val
    210                 215                 220                 
Phe Asn Ile Ile Ile Thr Gln Thr Leu Tyr Asp Leu Gln Ser Gly Asn
225                 230                 235                 240 
Ser Gly Glu Lys Val Ser Lys Val Ser Leu Val Asp Leu Ala Gly Ser
                245                 250                 255     
Glu Arg Val Ser Lys Thr Gly Ala Ala Gly Glu Arg Leu Lys Glu Gly
            260                 265                 270         
Ser Asn Ile Asn Lys Ser Leu Thr Thr Leu Gly Leu Val Ile Ser Ser
        275                 280                 285             
Leu Ala Asp Gln Ala Ala Gly Lys Gly Lys Ser Lys Phe Val Pro Tyr
    290                 295                 300                 
Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Asn Leu Gly Gly Asn
305                 310                 315                 320 
Ser Gln Thr Ser Met Ile Ala Thr Ile Ser Pro Ala Ala Asp Asn Tyr
                325                 330                 335     
Glu Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Arg Ile
            340                 345                 350         
Val Asn His Ala Val Val Asn Glu Asp Pro Asn Ala Lys Val Ile Arg
        355                 360                 365             
Glu Leu Arg Glu Glu Val Glu Lys Leu Arg Glu Gln Leu Ser Gln Ala
    370                 375                 380                 
Glu Ala Met Lys Ala Pro Glu Leu Lys Glu Lys Leu Glu Glu Ser Glu
385                 390                 395                 400 
Lys Leu Ile Lys Glu Leu Thr Val Thr Trp Glu Glu Lys Leu Arg Lys
                405                 410                 415     
Thr Glu Glu Ile Ala Gln Glu Arg Gln Arg Gln Leu Glu Ser Met Gly
            420                 425                 430         
Ile Ser Leu Glu Met Ser Gly Ile Lys Val Gly Asp Asp Lys Cys Tyr
        435                 440                 445             
Leu Val Asn Leu Asn Ala Asp Pro Ala Leu Asn Glu Leu Leu Val Tyr
    450                 455                 460                 
Tyr Leu Lys Asp His Thr Arg Val Gly Ala Asp Thr Ser Gln Asp Ile
465                 470                 475                 480 
Gln Leu Phe Gly Ile Gly Ile Gln Pro Gln His Cys Glu Ile Asp Ile
                485                 490                 495     
Ala Ser Asp Gly Asp Val Thr Leu Thr Pro Lys Glu Asn Ala Arg Ser
            500                 505                 510         
Cys Val Asn Gly Thr Leu Val Cys Ser Thr Thr Gln Leu Trp His Gly
        515                 520                 525             
Asp Arg Ile Leu Trp Gly Asn Asn His Phe Phe Arg Ile Asn Leu Pro
    530                 535                 540                 
Lys Arg Lys Arg Arg Asp Trp Leu Lys Asp Phe Glu Lys Glu Thr Gly
545                 550                 555                 560 
Pro Pro Glu His Asp Leu Asp Ala Ala Ser Glu Ala Ser Ser Glu Pro
                565                 570                 575     
Asp Tyr Asn Tyr Glu Phe Ala Gln Met Glu Val Ile Met Lys Thr Leu
            580                 585                 590         
Asn Ser Asn Asp Pro Val Gln Asn Val Val Gln Val Leu Glu Lys Gln
        595                 600                 605             
Tyr Leu Glu Glu Lys Arg Ser Ala Leu Glu Glu Gln Arg Leu Met Tyr
    610                 615                 620                 
Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser Pro Asp Arg Gln
625                 630                 635                 640 
Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser Ser Gln Thr Ala
                645                 650                 655     
Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp Glu Leu Phe Arg
            660                 665                 670         
Gln Ser Leu Ala Lys Leu Arg Glu Gln Leu Val Lys Ala Asn Thr Leu
        675                 680                 685             
Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser Lys Leu Thr Asp
    690                 695                 700                 
Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu Ser Ala Asn Arg
705                 710                 715                 720 
Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln Val Arg Arg Lys
                725                 730                 735     
Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu Glu Asn Lys Leu
            740                 745                 750         
Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Lys Val Pro Glu
        755                 760                 765             
Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe Tyr Glu Ala Gln
    770                 775                 780                 
Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe Leu Glu Cys Leu
785                 790                 795                 800 
Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile Ile Ser Gln Gln
                805                 810                 815     
Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met Arg Val Thr Gly
            820                 825                 830         
Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser Glu Asn Ser Ser
        835                 840                 845             
Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly Glu Ile Ile His
    850                 855                 860                 
Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys Glu Ala Thr Gly
865                 870                 875                 880 
Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln Tyr Thr Phe Trp
                885                 890                 895     
Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val Asp Pro Glu Val
            900                 905                 910         
Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val Thr Phe Ser His
        915                 920                 925             
Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe Leu Glu Phe Ile
    930                 935                 940                 
Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His Arg Cys Ala Gly
945                 950                 955                 960 
Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His Ala Lys Thr Arg
                965                 970                 975     
Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg Ile Glu Met Trp
            980                 985                 990         
Ile Ser Ile Leu Glu Leu Asn Glu Leu Gly Glu Tyr Ala Ala Val Glu
        995                 1000                1005            
Leu His Gln Ala Lys Asp Val Asn Thr Gly Gly Ile Phe Gln Leu Arg
    1010                1015                1020                
Gln Gly His Ser Arg Arg Val Gln Val Thr Val Lys Pro Val Gln His
1025                1030                1035                1040
Ser Gly Thr Leu Pro Leu Met Val Glu Ala Ile Leu Ser Val Ser Ile
                1045                1050                1055    
Gly Cys Val Thr Ala Arg Ser Thr Lys Leu Gln Arg Gly Leu Asp Ser
            1060                1065                1070        
Tyr Gln Glu Glu Asp Leu Asn Cys Val Arg Glu Arg Trp Ser Asp Ala
        1075                1080                1085            
Leu Ile Lys Arg Arg Glu Tyr Leu Asp Glu Gln Ile Lys Lys Val Ser
    1090                1095                1100                
Asn Lys Thr Glu Lys Thr Glu Asp Asp Val Glu Arg Glu Ala Gln Leu
1105                1110                1115                1120
Val Glu Gln Trp Val Gly Leu Thr Glu Glu Arg Asn Ala Val Leu Val
                1125                1130                1135    
Pro Ala Pro Gly Ser Gly Ile Pro Gly Ala Pro Ala Asp Trp Ile Pro
            1140                1145                1150        
Pro Pro Gly Met Glu Thr His Ile Pro Val Leu Phe Leu Asp Leu Asn
        1155                1160                1165            
Ala Asp Asp Leu Ser Ala Asn Glu Gln Leu Val Gly Pro His Ala Ser
    1170                1175                1180                
Gly Val Asn Ser Ile Leu Pro Lys Glu His Gly Ser Gln Phe Phe Tyr
1185                1190                1195                1200
Leu Pro Ile Ile Lys His Ser Asp Asp Glu Val Ser Ala Thr Ala Ser
                1205                1210                1215    
Trp Asp Ser Ser Val His Asp Ser Val His Leu Asn Arg Val Thr Pro
            1220                1225                1230        
Gln Asn Glu Arg Ile Tyr Leu Ile Val Lys Thr Thr Val Gln Leu Ser
        1235                1240                1245            
His Pro Ala Ala Met Glu Leu Val Leu Arg Lys Arg Ile Ala Ala Asn
    1250                1255                1260                
Ile Tyr Asn Lys Gln Ser Phe Thr Gln Ser Leu Lys Arg Arg Ile Ser
1265                1270                1275                1280
Leu Lys Asn Ile Phe Tyr Ser Cys Gly Val Thr Tyr Glu Ile Val Ser
                1285                1290                1295    
Asn Ile Pro Lys Ala Thr Glu Glu Ile Glu Asp Arg Glu Thr Leu Ala
            1300                1305                1310        
Leu Leu Ala Ala Arg Ser Glu Asn Glu Gly Thr Ser Asp Gly Glu Thr
        1315                1320                1325            
Tyr Ile Glu Lys Tyr Thr Arg Gly Val Leu Gln Val Glu Asn Ile Leu
    1330                1335                1340                
Ser Leu Glu Arg Leu Arg Gln Ala Val Thr Val Lys Glu Ala Leu Ser
1345                1350                1355                1360
Thr Lys Ala Arg His Ile Arg Arg Ser Leu Ser Thr Pro Asn Val His
                1365                1370                1375    
Asn Val Ser Ser Ser Arg Pro Asp Leu Ser Gly Phe Asp Glu Asp Asp
            1380                1385                1390        
Lys Gly Trp Pro Glu Asn Gln Leu Asp Met Ser Asp Tyr Ser Ser Ser
        1395                1400                1405            
Tyr Gln Asp Val Ala Cys Tyr Gly Thr Leu Pro Arg Asp Ser Pro Arg
    1410                1415                1420                
Arg Asn Lys Glu Gly Cys Thr Ser Glu Thr Pro His Ala Leu Thr Val
1425                1430                1435                1440
Ser Pro Phe Lys Ala Phe Ser Pro Gln Pro Pro Lys Phe Phe Lys Pro
                1445                1450                1455    
Leu Met Pro Val Lys Glu Glu His Lys Lys Arg Ile Ala Leu Glu Ala
            1460                1465                1470        
Arg Pro Leu Leu Ser Gln Glu Asp Ser Glu Glu Glu Glu Asn Glu Leu
        1475                1480                1485            
Glu Ala Ile Asn Arg Lys Leu Ile Ser Ser Gln Pro Tyr Val Pro Val
    1490                1495                1500                
Glu Phe Ala Asp Phe Ser Val Tyr Asn Ala Ser Leu Glu Asn Arg Glu
1505                1510                1515                1520
Trp Phe Ser Ser Lys Val Asp Leu Ser Asn Ser Arg Val Leu Glu Lys
                1525                1530                1535    
Glu Val Ser Arg Ser Pro Thr Thr Ser Ser Ile Thr Ser Gly Tyr Phe
            1540                1545                1550        
Ser His Ser Ala Ser Asn Ala Thr Leu Ser Asp Met Val Val Pro Ser
        1555                1560                1565            
Ser Asp Ser Ser Asp Gln Leu Ala Ile Gln Thr Lys Asp Ala Asp Ser
    1570                1575                1580                
Thr Glu His Ser Thr Pro Ser Leu Val His Asp Phe Arg Pro Ser Ser
1585                1590                1595                1600
Asn Lys Glu Leu Thr Glu Val Glu Lys Gly Leu Val Lys Asp Lys Ile
                1605                1610                1615    
Ile Val Val Pro Leu Lys Glu Asn Ser Ala Leu Ala Lys Gly Ser Pro
            1620                1625                1630        
Ser Ser Gln Ser Ile Pro Glu Lys Asn Ser Lys Ser Leu Cys Arg Thr
        1635                1640                1645            
Gly Ser Cys Ser Glu Leu Asp Ala Cys Pro Ser Lys Ile Ser Gln Pro
    1650                1655                1660                
Ala Arg Gly Phe Cys Pro Arg Glu Val Thr Val Glu His Thr Thr Asn
1665                1670                1675                1680
Ile Leu Glu Asp His Ser Phe Thr Glu Phe Met Gly Val Ser Glu Gly
                1685                1690                1695    
Lys Asp Phe Asp Gly Leu Thr Asp Ser Ser Ala Gly Glu Leu Ser Ser
            1700                1705                1710        
Arg Arg Ser Leu Pro Asn Lys Thr Gly Gly Lys Thr Val Ser Asp Gly
        1715                1720                1725            
Leu His His Pro Ser Gln Leu His Ser Lys Leu Glu Asn Asp Gln Gly
    1730                1735                1740                
Gly Thr Thr Ser Arg
1745                


<210> 6009
<211> 1770
<212> PRT
<213> Homo sapiens

<400> 6009
Met Ser Asp Thr Lys Val Lys Val Ala Val Arg Val Arg Pro Met Asn
 1               5                  10                  15      
Arg Arg Glu Leu Glu Leu Asn Thr Lys Cys Val Val Glu Met Glu Gly
            20                  25                  30          
Asn Gln Thr Val Leu His Pro Pro Pro Ser Asn Thr Lys Gln Gly Glu
        35                  40                  45              
Arg Lys Pro Pro Lys Val Phe Ala Phe Asp Tyr Cys Phe Trp Ser Met
    50                  55                  60                  
Asp Glu Ser Asn Thr Thr Lys Tyr Ala Gly Gln Glu Val Val Phe Lys
65                  70                  75                  80  
Cys Leu Gly Glu Gly Ile Leu Glu Lys Ala Phe Gln Gly Tyr Asn Ala
                85                  90                  95      
Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Phe Ser Met
            100                 105                 110         
Met Gly His Ala Glu Gln Leu Gly Leu Ile Pro Arg Leu Cys Cys Ala
        115                 120                 125             
Leu Phe Lys Arg Ile Ser Leu Glu Gln Asn Glu Ser Gln Thr Phe Lys
    130                 135                 140                 
Val Glu Val Ser Tyr Met Glu Ile Tyr Asn Glu Lys Val Arg Asp Leu
145                 150                 155                 160 
Leu Asp Pro Lys Gly Ser Arg Gln Ser Leu Lys Val Arg Glu His Lys
                165                 170                 175     
Val Leu Gly Pro Tyr Val Asp Gly Leu Ser Gln Leu Ala Val Thr Ser
            180                 185                 190         
Phe Glu Asp Ile Glu Ser Leu Met Ser Glu Gly Asn Lys Ser Arg Thr
        195                 200                 205             
Val Ala Ala Thr Asn Met Asn Glu Glu Ser Ser Arg Ser His Ala Val
    210                 215                 220                 
Phe Asn Ile Ile Ile Thr Gln Thr Leu Tyr Asp Leu Gln Ser Gly Asn
225                 230                 235                 240 
Ser Gly Glu Lys Val Ser Lys Val Ser Leu Val Asp Leu Ala Gly Ser
                245                 250                 255     
Glu Arg Val Ser Lys Thr Gly Ala Ala Gly Glu Arg Leu Lys Glu Gly
            260                 265                 270         
Ser Asn Ile Asn Lys Ser Leu Thr Thr Leu Gly Leu Val Ile Ser Ser
        275                 280                 285             
Leu Ala Asp Gln Ala Ala Gly Lys Gly Lys Ser Lys Phe Val Pro Tyr
    290                 295                 300                 
Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Asn Leu Gly Gly Asn
305                 310                 315                 320 
Ser Gln Thr Ser Met Ile Ala Thr Ile Ser Pro Ala Ala Asp Asn Tyr
                325                 330                 335     
Glu Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Arg Ile
            340                 345                 350         
Val Asn His Ala Val Val Asn Glu Asp Pro Asn Ala Lys Val Ile Arg
        355                 360                 365             
Glu Leu Arg Glu Glu Val Glu Lys Leu Arg Glu Gln Leu Ser Gln Ala
    370                 375                 380                 
Glu Ala Met Lys Ala Pro Glu Leu Lys Glu Lys Leu Glu Glu Ser Glu
385                 390                 395                 400 
Lys Leu Ile Lys Glu Leu Thr Val Thr Trp Glu Glu Lys Leu Arg Lys
                405                 410                 415     
Thr Glu Glu Ile Ala Gln Glu Arg Gln Arg Gln Leu Glu Ser Met Gly
            420                 425                 430         
Ile Ser Leu Glu Met Ser Gly Ile Lys Val Gly Asp Asp Lys Cys Tyr
        435                 440                 445             
Leu Val Asn Leu Asn Ala Asp Pro Ala Leu Asn Glu Leu Leu Val Tyr
    450                 455                 460                 
Tyr Leu Lys Asp His Thr Arg Val Gly Ala Asp Thr Ser Gln Asp Ile
465                 470                 475                 480 
Gln Leu Phe Gly Ile Gly Ile Gln Pro Gln His Cys Glu Ile Asp Ile
                485                 490                 495     
Ala Ser Asp Gly Asp Val Thr Leu Thr Pro Lys Glu Asn Ala Arg Ser
            500                 505                 510         
Cys Val Asn Gly Thr Leu Val Cys Ser Thr Thr Gln Leu Trp His Gly
        515                 520                 525             
Asp Arg Ile Leu Trp Gly Asn Asn His Phe Phe Arg Ile Asn Leu Pro
    530                 535                 540                 
Lys Arg Lys Arg Arg Asp Trp Leu Lys Asp Phe Glu Lys Glu Thr Gly
545                 550                 555                 560 
Pro Pro Glu His Asp Leu Asp Ala Ala Ser Glu Ala Ser Ser Glu Pro
                565                 570                 575     
Asp Tyr Asn Tyr Glu Phe Ala Gln Met Glu Val Ile Met Lys Thr Leu
            580                 585                 590         
Asn Ser Asn Asp Pro Val Gln Asn Val Val Gln Val Leu Glu Lys Gln
        595                 600                 605             
Tyr Leu Glu Glu Lys Arg Ser Ala Leu Glu Glu Gln Arg Leu Met Tyr
    610                 615                 620                 
Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser Pro Asp Arg Gln
625                 630                 635                 640 
Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser Ser Gln Thr Ala
                645                 650                 655     
Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp Glu Leu Phe Arg
            660                 665                 670         
Gln Gly Leu Ala Lys Leu Arg Glu Gln Leu Val Lys Ala Asn Thr Leu
        675                 680                 685             
Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser Lys Leu Thr Asp
    690                 695                 700                 
Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu Ser Ala Asn Arg
705                 710                 715                 720 
Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln Val Arg Arg Lys
                725                 730                 735     
Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu Glu Asn Lys Leu
            740                 745                 750         
Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Lys Val Pro Glu
        755                 760                 765             
Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe Tyr Glu Ala Gln
    770                 775                 780                 
Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe Leu Glu Cys Leu
785                 790                 795                 800 
Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile Ile Ser Gln Gln
                805                 810                 815     
Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met Arg Val Thr Gly
            820                 825                 830         
Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser Glu Asn Ser Ser
        835                 840                 845             
Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly Glu Ile Ile His
    850                 855                 860                 
Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys Glu Ala Thr Gly
865                 870                 875                 880 
Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln Tyr Thr Phe Trp
                885                 890                 895     
Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val Asp Pro Glu Val
            900                 905                 910         
Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val Ala Phe Ser His
        915                 920                 925             
Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe Leu Glu Phe Ile
    930                 935                 940                 
Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His Arg Cys Ala Gly
945                 950                 955                 960 
Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His Ala Lys Thr Arg
                965                 970                 975     
Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg Ile Glu Met Trp
            980                 985                 990         
Ile Ser Ile Leu Glu Leu Asn Glu Leu Gly Glu Tyr Ala Ala Val Glu
        995                 1000                1005            
Leu His Gln Ala Lys Asp Val Asn Thr Gly Gly Ile Phe Gln Leu Arg
    1010                1015                1020                
Gln Gly His Ser Arg Arg Val Gln Val Thr Val Lys Pro Val Gln His
1025                1030                1035                1040
Ser Gly Thr Leu Pro Leu Met Val Glu Ala Ile Leu Ser Val Ser Ile
                1045                1050                1055    
Gly Cys Val Thr Ala Arg Ser Thr Lys Leu Gln Arg Gly Leu Asp Ser
            1060                1065                1070        
Tyr Gln Arg Asp Asp Glu Asp Gly Asp Asp Met Asp Ser Tyr Gln Glu
        1075                1080                1085            
Glu Asp Leu Asn Cys Val Arg Glu Arg Trp Ser Asp Ala Leu Ile Lys
    1090                1095                1100                
Arg Arg Glu Tyr Leu Asp Glu Gln Ile Lys Lys Val Ser Asn Lys Thr
1105                1110                1115                1120
Glu Lys Thr Glu Asp Asp Val Glu Arg Glu Ala Gln Leu Val Glu Gln
                1125                1130                1135    
Trp Val Gly Leu Thr Glu Glu Arg Asn Ala Val Leu Val Pro Ala Pro
            1140                1145                1150        
Gly Ser Gly Ile Pro Gly Ala Pro Ala Asp Trp Ile Pro Pro Pro Gly
        1155                1160                1165            
Met Glu Thr His Ile Pro Val Leu Phe Leu Asp Leu Asn Ala Asp Asp
    1170                1175                1180                
Pro Ser Ala Asn Glu Gln Leu Val Gly Pro His Ala Ser Gly Val Asn
1185                1190                1195                1200
Ser Ile Leu Pro Lys Glu His Gly Ser Gln Phe Phe Tyr Leu Pro Ile
                1205                1210                1215    
Ile Lys His Ser Asp Asp Glu Val Ser Ala Thr Ala Ser Trp Asp Ser
            1220                1225                1230        
Ser Val His Asp Ser Val His Leu Asn Arg Val Thr Pro Gln Asn Glu
        1235                1240                1245            
Arg Ile Tyr Leu Ile Val Lys Thr Thr Val Gln Leu Ser His Pro Ala
    1250                1255                1260                
Ala Met Glu Leu Val Leu Arg Lys Arg Ile Ala Ala Asn Ile Tyr Asn
1265                1270                1275                1280
Lys Gln Ser Phe Thr Gln Ser Leu Lys Arg Arg Ile Ser Leu Lys Asn
                1285                1290                1295    
Ile Phe Tyr Ser Cys Gly Val Thr Tyr Glu Ile Val Ser Asn Ile Pro
            1300                1305                1310        
Lys Ala Thr Glu Glu Ile Glu Asp Arg Glu Thr Leu Ala Leu Leu Ala
        1315                1320                1325            
Ala Arg Ser Glu Asn Glu Gly Thr Ser Asp Gly Glu Thr Tyr Ile Glu
    1330                1335                1340                
Lys Tyr Thr Arg Gly Val Leu Gln Val Glu Asn Ile Leu Ser Leu Glu
1345                1350                1355                1360
Arg Leu Arg Gln Ala Val Thr Val Lys Glu Ala Leu Ser Thr Lys Ala
                1365                1370                1375    
Arg His Ile Arg Arg Ser Leu Ser Thr Pro Asn Val His Asn Val Ser
            1380                1385                1390        
Ser Ser Arg Pro Asp Leu Ser Gly Phe Asp Glu Asp Asp Lys Gly Trp
        1395                1400                1405            
Pro Glu Asn Gln Leu Asp Met Ser Asp Tyr Ser Ser Ser Tyr Gln Asp
    1410                1415                1420                
Val Ala Cys Tyr Gly Thr Leu Pro Arg Asp Ser Pro Arg Arg Asn Lys
1425                1430                1435                1440
Glu Gly Cys Thr Ser Glu Thr Pro His Ala Leu Thr Val Ser Pro Phe
                1445                1450                1455    
Lys Ala Phe Ser Pro Gln Pro Pro Lys Phe Phe Lys Pro Leu Met Pro
            1460                1465                1470        
Val Lys Glu Glu His Lys Lys Arg Ile Ala Leu Glu Ala Arg Pro Leu
        1475                1480                1485            
Leu Ser Gln Glu Asp Ser Glu Glu Glu Glu Asn Glu Leu Glu Ala Ile
    1490                1495                1500                
Asn Arg Lys Leu Ile Ser Ser Gln Pro Tyr Val Pro Val Glu Phe Ala
1505                1510                1515                1520
Asp Phe Ser Val Tyr Asn Ala Ser Leu Glu Asn Arg Glu Trp Phe Ser
                1525                1530                1535    
Ser Lys Val Asp Leu Ser Asn Ser Arg Val Leu Glu Lys Glu Val Ser
            1540                1545                1550        
Arg Ser Pro Thr Thr Ser Ser Ile Thr Ser Gly Tyr Phe Ser His Ser
        1555                1560                1565            
Ala Ser Asn Ala Thr Leu Ser Asp Met Val Val Pro Ser Ser Asp Ser
    1570                1575                1580                
Ser Asp Gln Leu Ala Ile Gln Thr Lys Asp Ala Asp Ser Thr Glu His
1585                1590                1595                1600
Ser Thr Pro Ser Leu Val His Asp Phe Arg Pro Ser Ser Asn Lys Glu
                1605                1610                1615    
Leu Thr Glu Val Glu Lys Gly Leu Val Lys Asp Lys Ile Ile Val Val
            1620                1625                1630        
Pro Leu Lys Glu Asn Ser Ala Leu Ala Lys Gly Ser Pro Ser Ser Gln
        1635                1640                1645            
Ser Ile Pro Glu Lys Asn Ser Lys Ser Leu Cys Arg Thr Gly Ser Cys
    1650                1655                1660                
Ser Glu Leu Asp Ala Cys Pro Ser Lys Ile Ser Gln Pro Ala Arg Gly
1665                1670                1675                1680
Phe Cys Pro Arg Glu Val Thr Val Glu His Thr Thr Asn Ile Leu Glu
                1685                1690                1695    
Asp His Ser Phe Thr Glu Phe Met Gly Val Ser Glu Gly Lys Asp Phe
            1700                1705                1710        
Asp Gly Leu Thr Asp Ser Ser Ala Gly Glu Leu Ser Ser Arg Arg Ser
        1715                1720                1725            
Leu Pro Asn Lys Thr Gly Gly Lys Thr Val Ser Asp Gly Leu His His
    1730                1735                1740                
Pro Ser Gln Leu His Ser Lys Leu Glu Asn Asp Gln Val Ile Ile Pro
1745                1750                1755                1760
Glu Ala Ala Phe Trp Val Leu Cys Cys Gln
                1765                1770


<210> 6010
<211> 1051
<212> PRT
<213> Homo sapiens

<400> 6010
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu
 1               5                  10                  15      
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala
            20                  25                  30          
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
        35                  40                  45              
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
    50                  55                  60                  
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
65                  70                  75                  80  
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
                85                  90                  95      
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
            100                 105                 110         
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
        115                 120                 125             
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
    130                 135                 140                 
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
145                 150                 155                 160 
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
                165                 170                 175     
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
            180                 185                 190         
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
        195                 200                 205             
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
    210                 215                 220                 
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
225                 230                 235                 240 
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
                245                 250                 255     
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
            260                 265                 270         
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
        275                 280                 285             
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
    290                 295                 300                 
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
305                 310                 315                 320 
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
                325                 330                 335     
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
            340                 345                 350         
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
        355                 360                 365             
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
    370                 375                 380                 
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
385                 390                 395                 400 
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
                405                 410                 415     
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
            420                 425                 430         
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
        435                 440                 445             
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
    450                 455                 460                 
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
465                 470                 475                 480 
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
                485                 490                 495     
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
            500                 505                 510         
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
        515                 520                 525             
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
    530                 535                 540                 
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
545                 550                 555                 560 
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
                565                 570                 575     
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
            580                 585                 590         
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
        595                 600                 605             
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
    610                 615                 620                 
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
625                 630                 635                 640 
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
                645                 650                 655     
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
            660                 665                 670         
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
        675                 680                 685             
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
    690                 695                 700                 
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
705                 710                 715                 720 
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
                725                 730                 735     
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
            740                 745                 750         
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
        755                 760                 765             
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
    770                 775                 780                 
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
785                 790                 795                 800 
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
                805                 810                 815     
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
            820                 825                 830         
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
        835                 840                 845             
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
    850                 855                 860                 
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
865                 870                 875                 880 
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
                885                 890                 895     
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
            900                 905                 910         
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
        915                 920                 925             
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
    930                 935                 940                 
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
945                 950                 955                 960 
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
                965                 970                 975     
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
            980                 985                 990         
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
        995                 1000                1005            
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Ala Arg Thr
    1010                1015                1020                
Arg Ala Leu Tyr Glu Ala Lys Arg Gln Lys Ala Glu Met Lys Ser Gln
1025                1030                1035                1040
Pro Ser Glu Thr Glu Arg Leu Thr Asp Asp Tyr
                1045                1050    


<210> 6011
<211> 1066
<212> PRT
<213> Homo sapiens

<400> 6011
Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu
 1               5                  10                  15      
Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala
            20                  25                  30          
Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro
        35                  40                  45              
Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg
    50                  55                  60                  
Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val
65                  70                  75                  80  
Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu
                85                  90                  95      
Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn
            100                 105                 110         
Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val
        115                 120                 125             
Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr
    130                 135                 140                 
Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly
145                 150                 155                 160 
Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp
                165                 170                 175     
Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu
            180                 185                 190         
Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn
        195                 200                 205             
Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser
    210                 215                 220                 
Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys
225                 230                 235                 240 
Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val
                245                 250                 255     
Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala
            260                 265                 270         
Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala
        275                 280                 285             
Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly
    290                 295                 300                 
Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly
305                 310                 315                 320 
Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu
                325                 330                 335     
Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser
            340                 345                 350         
Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala
        355                 360                 365             
Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe
    370                 375                 380                 
Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr
385                 390                 395                 400 
Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val
                405                 410                 415     
Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr
            420                 425                 430         
Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu
        435                 440                 445             
Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro
    450                 455                 460                 
Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu
465                 470                 475                 480 
Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys
                485                 490                 495     
Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile
            500                 505                 510         
Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg
        515                 520                 525             
Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser
    530                 535                 540                 
Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn
545                 550                 555                 560 
Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu
                565                 570                 575     
Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp
            580                 585                 590         
Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu
        595                 600                 605             
Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn
    610                 615                 620                 
Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser
625                 630                 635                 640 
Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn
                645                 650                 655     
Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu
            660                 665                 670         
Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val
        675                 680                 685             
Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu
    690                 695                 700                 
Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe
705                 710                 715                 720 
Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu
                725                 730                 735     
Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu
            740                 745                 750         
Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn
        755                 760                 765             
His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly
    770                 775                 780                 
Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln
785                 790                 795                 800 
Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu
                805                 810                 815     
Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr
            820                 825                 830         
Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro
        835                 840                 845             
Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly
    850                 855                 860                 
Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly
865                 870                 875                 880 
Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala
                885                 890                 895     
Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val
            900                 905                 910         
Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr
        915                 920                 925             
Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp
    930                 935                 940                 
Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr
945                 950                 955                 960 
Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val
                965                 970                 975     
Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu
            980                 985                 990         
Trp Leu Val Leu Val Ala Val Gly Ala Gly Leu Leu Leu Leu Gly Leu
        995                 1000                1005            
Ile Ile Leu Leu Leu Trp Lys Cys Gly Phe Phe Lys Arg Thr Arg Tyr
    1010                1015                1020                
Tyr Gln Ile Met Pro Lys Tyr His Ala Val Arg Ile Arg Glu Glu Glu
1025                1030                1035                1040
Arg Tyr Pro Pro Pro Gly Ser Thr Leu Pro Thr Lys Lys His Trp Val
                1045                1050                1055    
Thr Ser Trp Gln Thr Arg Asp Gln Tyr Tyr
            1060                1065    


<210> 6012
<211> 384
<212> PRT
<213> Homo sapiens

<400> 6012
Met Glu Gly Leu Gly Arg Ser Cys Leu Trp Leu Arg Arg Glu Leu Ser
 1               5                  10                  15      
Pro Pro Arg Pro Arg Leu Leu Leu Leu Asp Cys Arg Ser Arg Glu Leu
            20                  25                  30          
Tyr Glu Ser Ala Arg Ile Gly Gly Ala Leu Ser Val Ala Leu Pro Ala
        35                  40                  45              
Leu Leu Leu Arg Arg Leu Arg Arg Gly Ser Leu Ser Val Arg Ala Leu
    50                  55                  60                  
Leu Pro Gly Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro Val Leu Leu
65                  70                  75                  80  
Tyr Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala Glu Ala Glu
                85                  90                  95      
Ala Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu Leu Gln Lys
            100                 105                 110         
Leu Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly Gly Phe Ser
        115                 120                 125             
Arg Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser Leu Ala Gly
    130                 135                 140                 
Arg Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val Pro Val Val
145                 150                 155                 160 
Gly Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp Ala Glu Ser
                165                 170                 175     
Glu Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser Glu Gly Ala
            180                 185                 190         
Thr Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val Gln Ile Leu
        195                 200                 205             
Pro Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn Leu Glu Ser
    210                 215                 220                 
Leu Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr Pro Asn Leu
225                 230                 235                 240 
Pro Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys Gln Ile Pro
                245                 250                 255     
Ile Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe Pro Glu Ala
            260                 265                 270         
Ile Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly Val Leu Val
        275                 280                 285             
His Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr Val Ala Tyr
    290                 295                 300                 
Leu Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr Asp Leu Val
305                 310                 315                 320 
Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln
                325                 330                 335     
Leu Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg His Ser Gln
            340                 345                 350         
Glu Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn Pro Pro Ser
        355                 360                 365             
Phe Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu Ala Pro Thr
    370                 375                 380                 


<210> 6013
<211> 354
<212> PRT
<213> Homo sapiens

<400> 6013
Ser Leu Ala Ser Ser Leu Arg Asn Lys Glu Gly Thr Leu Gly Ser Lys
 1               5                  10                  15      
Val Gly Tyr Leu Asp Val Glu Ala Arg Gly Pro Gly Glu Gly Arg Gly
            20                  25                  30          
Gly Gly Gly Glu Ser Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro Val
        35                  40                  45              
Leu Leu Tyr Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala Glu
    50                  55                  60                  
Ala Glu Ala Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu Leu
65                  70                  75                  80  
Gln Lys Leu Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly Gly
                85                  90                  95      
Phe Ser Arg Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser Leu
            100                 105                 110         
Ala Gly Arg Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val Pro
        115                 120                 125             
Val Val Gly Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp Ala
    130                 135                 140                 
Glu Ser Glu Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser Glu
145                 150                 155                 160 
Gly Ala Thr Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val Gln
                165                 170                 175     
Ile Leu Pro Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn Leu
            180                 185                 190         
Glu Ser Leu Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr Pro
        195                 200                 205             
Asn Leu Pro Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys Gln
    210                 215                 220                 
Ile Pro Ile Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe Pro
225                 230                 235                 240 
Glu Ala Ile Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly Val
                245                 250                 255     
Leu Val His Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr Val
            260                 265                 270         
Ala Tyr Leu Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr Asp
        275                 280                 285             
Leu Val Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met
    290                 295                 300                 
Gly Gln Leu Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg His
305                 310                 315                 320 
Ser Gln Glu Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn Pro
                325                 330                 335     
Pro Ser Phe Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu Ala
            340                 345                 350         
Pro Thr
        


<210> 6014
<211> 570
<212> PRT
<213> Homo sapiens

<400> 6014
Met Arg Arg Leu Gly Pro Phe His Pro Arg Val His Trp Ala Ala Pro
 1               5                  10                  15      
Pro Ser Leu Ser Ser Gly Leu His Arg Leu Leu Phe Leu Arg Gly Thr
            20                  25                  30          
Arg Ile Pro Ser Ser Thr Thr Leu Ser Pro Pro Arg His Asp Ser Leu
        35                  40                  45              
Ser Leu Asp Gly Gly Thr Val Asn Pro Pro Arg Val Arg Glu Pro Thr
    50                  55                  60                  
Gly Arg Glu Ala Phe Gly Pro Ser Pro Ala Ser Ser Asp Trp Leu Pro
65                  70                  75                  80  
Ala Arg Trp Arg Asn Gly Arg Gly Gly Arg Pro Arg Ala Arg Leu Cys
                85                  90                  95      
Ser Gly Trp Thr Ala Ala Glu Glu Ala Arg Arg Asn Pro Thr Leu Gly
            100                 105                 110         
Gly Leu Leu Gly Arg Gln Arg Leu Leu Leu Arg Met Gly Ala Gly Arg
        115                 120                 125             
Leu Gly Ala Pro Met Glu Arg His Gly Arg Ala Ser Ala Thr Ser Val
    130                 135                 140                 
Ser Ser Ala Gly Glu Gln Ala Ala Gly Asp Pro Glu Gly Arg Arg Gln
145                 150                 155                 160 
Glu Pro Leu Arg Arg Arg Ala Ser Ser Ala Ser Val Pro Ala Val Gly
                165                 170                 175     
Ala Ser Ala Glu Gly Thr Arg Arg Asp Arg Leu Gly Ser Tyr Ser Gly
            180                 185                 190         
Pro Thr Ser Val Ser Arg Gln Arg Val Glu Ser Leu Arg Lys Lys Arg
        195                 200                 205             
Pro Leu Phe Pro Trp Phe Gly Leu Asp Ile Gly Gly Thr Leu Val Lys
    210                 215                 220                 
Leu Val Tyr Phe Glu Pro Lys Asp Ile Thr Ala Glu Glu Glu Glu Glu
225                 230                 235                 240 
Glu Val Glu Ser Leu Lys Ser Ile Arg Lys Tyr Leu Thr Ser Asn Val
                245                 250                 255     
Ala Tyr Gly Ser Thr Gly Ile Arg Asp Val His Leu Glu Leu Lys Asp
            260                 265                 270         
Leu Thr Leu Cys Gly Arg Lys Gly Asn Leu His Phe Ile Arg Phe Pro
        275                 280                 285             
Thr His Asp Met Pro Ala Phe Ile Gln Met Gly Arg Asp Lys Asn Phe
    290                 295                 300                 
Ser Ser Leu His Thr Val Phe Cys Ala Thr Gly Gly Gly Ala Tyr Lys
305                 310                 315                 320 
Phe Glu Gln Asp Phe Leu Thr Ile Gly Asp Leu Gln Leu Cys Lys Leu
                325                 330                 335     
Asp Glu Leu Asp Cys Leu Ile Lys Gly Ile Leu Tyr Ile Asp Ser Val
            340                 345                 350         
Gly Phe Asn Gly Arg Ser Gln Cys Tyr Tyr Phe Glu Asn Pro Ala Asp
        355                 360                 365             
Ser Glu Lys Cys Gln Lys Leu Pro Phe Asp Leu Lys Asn Pro Tyr Pro
    370                 375                 380                 
Leu Leu Leu Val Asn Ile Gly Ser Gly Val Ser Ile Leu Ala Val Tyr
385                 390                 395                 400 
Ser Lys Asp Asn Tyr Lys Arg Val Thr Gly Thr Ser Leu Gly Gly Gly
                405                 410                 415     
Thr Phe Phe Gly Leu Cys Cys Leu Leu Thr Gly Cys Thr Thr Phe Glu
            420                 425                 430         
Glu Ala Leu Glu Met Ala Ser Arg Gly Asp Ser Thr Lys Val Asp Lys
        435                 440                 445             
Leu Val Arg Asp Ile Tyr Gly Gly Asp Tyr Glu Arg Phe Gly Leu Pro
    450                 455                 460                 
Gly Trp Ala Val Ala Ser Ser Phe Gly Asn Met Met Ser Lys Glu Lys
465                 470                 475                 480 
Arg Glu Ala Val Ser Lys Glu Asp Leu Ala Arg Ala Thr Leu Ile Thr
                485                 490                 495     
Ile Thr Asn Asn Ile Gly Ser Ile Ala Arg Met Cys Ala Leu Asn Glu
            500                 505                 510         
Asn Ile Asn Gln Val Val Phe Val Gly Asn Phe Leu Arg Ile Asn Thr
        515                 520                 525             
Ile Ala Met Arg Leu Leu Ala Tyr Ala Leu Asp Tyr Trp Ser Lys Gly
    530                 535                 540                 
Gln Leu Lys Ala Leu Phe Ser Glu His Glu Gly Tyr Phe Gly Ala Val
545                 550                 555                 560 
Gly Ala Leu Leu Glu Leu Leu Lys Ile Pro
                565                 570 


<210> 6015
<211> 460
<212> PRT
<213> Homo sapiens

<400> 6015
Met Gly Gly Leu Leu Gly Arg Gln Arg Leu Leu Leu Arg Met Gly Gly
 1               5                  10                  15      
Gly Arg Leu Gly Ala Pro Met Glu Arg His Gly Arg Ala Ser Ala Thr
            20                  25                  30          
Ser Val Ser Ser Ala Gly Glu Gln Ala Ala Gly Asp Pro Glu Gly Arg
        35                  40                  45              
Arg Gln Glu Pro Leu Arg Arg Arg Ala Ser Ser Ala Ser Val Pro Ala
    50                  55                  60                  
Val Gly Ala Ser Ala Glu Gly Thr Arg Arg Asp Arg Leu Gly Ser Tyr
65                  70                  75                  80  
Ser Gly Pro Thr Ser Val Ser Arg Gln Arg Val Glu Ser Leu Arg Lys
                85                  90                  95      
Lys Arg Pro Leu Phe Pro Trp Phe Gly Leu Asp Ile Gly Gly Thr Leu
            100                 105                 110         
Val Lys Leu Val Tyr Phe Glu Pro Lys Asp Ile Thr Ala Glu Glu Glu
        115                 120                 125             
Glu Glu Glu Val Glu Ser Leu Lys Ser Ile Arg Lys Tyr Leu Thr Ser
    130                 135                 140                 
Asn Val Ala Tyr Gly Ser Thr Gly Ile Arg Asp Val His Leu Glu Leu
145                 150                 155                 160 
Lys Asp Leu Thr Leu Cys Gly Arg Lys Gly Asn Leu His Phe Ile Arg
                165                 170                 175     
Phe Pro Thr His Asp Met Pro Ala Phe Ile Gln Met Gly Arg Asp Lys
            180                 185                 190         
Asn Phe Ser Ser Leu His Thr Val Phe Cys Ala Thr Gly Gly Gly Ala
        195                 200                 205             
Tyr Lys Phe Glu Gln Asp Phe Leu Thr Ile Gly Asp Leu Gln Leu Cys
    210                 215                 220                 
Lys Leu Asp Glu Leu Asp Cys Leu Ile Lys Gly Ile Leu Tyr Ile Asp
225                 230                 235                 240 
Ser Val Gly Phe Asn Gly Arg Ser Gln Cys Tyr Tyr Phe Glu Asn Pro
                245                 250                 255     
Ala Asp Ser Glu Lys Cys Gln Lys Leu Pro Phe Asp Leu Lys Asn Pro
            260                 265                 270         
Tyr Pro Leu Leu Leu Val Asn Ile Gly Ser Gly Val Ser Ile Leu Ala
        275                 280                 285             
Val Tyr Ser Lys Asp Asn Tyr Lys Arg Val Thr Gly Thr Ser Leu Gly
    290                 295                 300                 
Gly Gly Thr Phe Phe Gly Leu Cys Cys Leu Leu Thr Gly Cys Thr Thr
305                 310                 315                 320 
Phe Glu Glu Ala Leu Glu Met Ala Ser Arg Gly Asp Ser Thr Lys Val
                325                 330                 335     
Asp Lys Leu Val Arg Asp Ile Tyr Gly Gly Asp Tyr Glu Arg Phe Gly
            340                 345                 350         
Leu Pro Gly Trp Ala Val Ala Ser Ser Phe Gly Asn Met Met Ser Lys
        355                 360                 365             
Glu Lys Arg Glu Ala Val Ser Lys Glu Asp Leu Ala Arg Ala Thr Leu
    370                 375                 380                 
Ile Thr Ile Thr Asn Asn Ile Gly Ser Ile Ala Arg Met Cys Ala Leu
385                 390                 395                 400 
Asn Glu Asn Ile Asn Gln Val Val Phe Val Gly Asn Phe Leu Arg Ile
                405                 410                 415     
Asn Thr Ile Ala Met Arg Leu Leu Ala Tyr Ala Leu Asp Tyr Trp Ser
            420                 425                 430         
Lys Gly Gln Leu Lys Ala Leu Phe Ser Glu His Glu Gly Tyr Phe Gly
        435                 440                 445             
Ala Val Gly Ala Leu Leu Glu Leu Leu Lys Ile Pro
    450                 455                 460 


<210> 6016
<211> 279
<212> PRT
<213> Homo sapiens

<400> 6016
Met Pro Ala Phe Ile Gln Met Gly Arg Asp Lys Asn Phe Ser Ser Leu
 1               5                  10                  15      
His Thr Val Phe Cys Ala Thr Gly Gly Gly Ala Tyr Lys Phe Glu Gln
            20                  25                  30          
Asp Phe Leu Thr Ile Gly Asp Leu Gln Leu Cys Lys Leu Asp Glu Leu
        35                  40                  45              
Asp Cys Leu Ile Lys Gly Ile Leu Tyr Ile Asp Ser Val Gly Phe Asn
    50                  55                  60                  
Gly Arg Ser Gln Cys Tyr Tyr Phe Glu Asn Pro Ala Asp Ser Glu Lys
65                  70                  75                  80  
Cys Gln Lys Leu Pro Phe Asp Leu Lys Asn Pro Tyr Pro Leu Leu Leu
                85                  90                  95      
Val Asn Ile Gly Ser Gly Val Ser Ile Leu Ala Val Tyr Ser Lys Asp
            100                 105                 110         
Asn Tyr Lys Arg Val Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Phe
        115                 120                 125             
Gly Leu Cys Cys Leu Leu Thr Gly Cys Thr Thr Phe Glu Glu Ala Leu
    130                 135                 140                 
Glu Met Ala Ser Arg Gly Asp Ser Thr Lys Val Asp Lys Leu Val Arg
145                 150                 155                 160 
Asp Ile Tyr Gly Gly Asp Tyr Glu Arg Phe Gly Leu Pro Gly Trp Ala
                165                 170                 175     
Val Ala Ser Ser Phe Gly Asn Met Met Ser Lys Glu Lys Arg Glu Ala
            180                 185                 190         
Val Ser Lys Glu Asp Leu Ala Arg Ala Thr Leu Ile Thr Ile Thr Asn
        195                 200                 205             
Asn Ile Gly Ser Ile Ala Arg Met Cys Ala Leu Asn Glu Asn Ile Asn
    210                 215                 220                 
Gln Val Val Phe Val Gly Asn Phe Leu Arg Ile Asn Thr Ile Ala Met
225                 230                 235                 240 
Arg Leu Leu Ala Tyr Ala Leu Asp Tyr Trp Ser Lys Gly Gln Leu Lys
                245                 250                 255     
Ala Leu Phe Ser Glu His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu
            260                 265                 270         
Leu Glu Leu Leu Lys Ile Pro
        275                 


<210> 6017
<211> 1960
<212> PRT
<213> Homo sapiens

<400> 6017
Met Gln Ser Phe Arg Glu Gln Ser Ser Tyr His Gly Asn Gln Gln Ser
 1               5                  10                  15      
Tyr Pro Gln Glu Val His Gly Ser Ser Arg Leu Glu Glu Phe Ser Pro
            20                  25                  30          
Arg Gln Ala Gln Met Phe Gln Asn Phe Gly Gly Thr Gly Gly Ser Ser
        35                  40                  45              
Gly Ser Ser Gly Ser Gly Ser Gly Gly Gly Arg Arg Gly Ala Ala Ala
    50                  55                  60                  
Ala Ala Ala Ala Met Ala Ser Glu Thr Ser Gly His Gln Gly Tyr Gln
65                  70                  75                  80  
Gly Phe Arg Lys Glu Ala Gly Asp Phe Tyr Tyr Met Ala Gly Asn Lys
                85                  90                  95      
Asp Pro Val Thr Thr Gly Thr Pro Gln Pro Pro Gln Arg Arg Pro Ser
            100                 105                 110         
Gly Pro Val Gln Ser Tyr Gly Pro Pro Arg Gly Ser Ser Phe Gly Asn
        115                 120                 125             
Gln Tyr Gly Ser Glu Gly His Val Gly Gln Phe Gln Ala Gln His Ser
    130                 135                 140                 
Gly Leu Gly Gly Val Ser His Tyr Gln Gln Asp Tyr Thr Gly Pro Phe
145                 150                 155                 160 
Ser Pro Gly Ser Ala Gln Tyr Gln Gln Gln Ala Ser Ser Gln Gln Gln
                165                 170                 175     
Gln Gln Gln Val Gln Gln Leu Arg Gln Gln Leu Tyr Gln Ser His Gln
            180                 185                 190         
Pro Leu Pro Gln Ala Thr Gly Lys Pro Ala Ser Ser Ser Ser His Leu
        195                 200                 205             
Gln Pro Met Gln Arg Pro Ser Thr Leu Pro Ser Ser Ala Ala Gly Tyr
    210                 215                 220                 
Gln Leu Arg Val Gly Gln Phe Gly Gln His Tyr Gln Ser Ser Ala Ser
225                 230                 235                 240 
Ser Ser Ser Ser Ser Ser Phe Pro Ser Pro Gln Arg Phe Ser Gln Ser
                245                 250                 255     
Gly Gln Ser Tyr Asp Gly Ser Tyr Asn Val Asn Ala Gly Ser Gln Tyr
            260                 265                 270         
Glu Gly His Asn Val Gly Ser Asn Ala Gln Ala Tyr Gly Thr Gln Ser
        275                 280                 285             
Asn Tyr Ser Tyr Gln Pro Gln Ser Met Lys Asn Phe Glu Gln Ala Lys
    290                 295                 300                 
Ile Pro Gln Gly Thr Gln Gln Gly Gln Gln Gln Gln Gln Pro Gln Gln
305                 310                 315                 320 
Gln Gln His Pro Ser Gln His Val Met Gln Tyr Thr Asn Ala Ala Thr
                325                 330                 335     
Lys Leu Pro Leu Gln Ser Gln Val Gly Gln Tyr Asn Gln Pro Glu Val
            340                 345                 350         
Pro Val Arg Ser Pro Met Gln Phe His Gln Asn Phe Ser Pro Ile Ser
        355                 360                 365             
Asn Pro Ser Pro Ala Ala Ser Val Val Gln Ser Pro Ser Cys Ser Ser
    370                 375                 380                 
Thr Pro Ser Pro Leu Met Gln Thr Gly Glu Asn Leu Gln Cys Gly Gln
385                 390                 395                 400 
Gly Ser Val Pro Met Gly Ser Arg Asn Arg Ile Leu Gln Leu Met Pro
                405                 410                 415     
Gln Leu Ser Pro Thr Pro Ser Met Met Pro Ser Pro Asn Ser His Ala
            420                 425                 430         
Ala Gly Phe Lys Gly Phe Gly Leu Glu Gly Val Pro Glu Lys Arg Leu
        435                 440                 445             
Thr Asp Pro Gly Leu Ser Ser Leu Ser Ala Leu Ser Thr Gln Val Ala
    450                 455                 460                 
Asn Leu Pro Asn Thr Val Gln His Met Leu Leu Ser Asp Ala Leu Thr
465                 470                 475                 480 
Pro Gln Lys Lys Thr Ser Lys Arg Pro Ser Ser Ser Lys Lys Ala Asp
                485                 490                 495     
Ser Cys Thr Asn Ser Glu Gly Ser Ser Gln Pro Glu Glu Gln Leu Lys
            500                 505                 510         
Ser Pro Met Ala Glu Ser Leu Asp Gly Gly Cys Ser Ser Ser Ser Glu
        515                 520                 525             
Asp Gln Gly Glu Arg Val Arg Gln Leu Ser Gly Gln Ser Thr Ser Ser
    530                 535                 540                 
Asp Thr Thr Tyr Lys Gly Gly Ala Ser Glu Lys Ala Gly Ser Ser Pro
545                 550                 555                 560 
Ala Gln Gly Ala Gln Asn Glu Pro Pro Arg Leu Asn Ala Ser Pro Ala
                565                 570                 575     
Ala Arg Glu Glu Ala Thr Ser Pro Gly Ala Lys Asp Met Pro Leu Ser
            580                 585                 590         
Ser Asp Gly Asn Pro Lys Val Asn Glu Lys Thr Val Gly Val Ile Val
        595                 600                 605             
Ser Arg Glu Ala Met Thr Gly Arg Val Glu Lys Pro Gly Gly Gln Asp
    610                 615                 620                 
Lys Gly Ser Gln Glu Asp Asp Pro Ala Ala Thr Gln Arg Pro Pro Ser
625                 630                 635                 640 
Asn Gly Gly Ala Lys Glu Thr Ser His Ala Ser Leu Pro Gln Pro Glu
                645                 650                 655     
Pro Pro Gly Gly Gly Gly Ser Lys Gly Asn Lys Asn Gly Asp Asn Asn
            660                 665                 670         
Ser Asn His Asn Gly Glu Gly Asn Gly Gln Ser Gly His Ser Ala Ala
        675                 680                 685             
Gly Pro Gly Phe Thr Ser Arg Thr Glu Pro Ser Lys Ser Pro Gly Ser
    690                 695                 700                 
Leu Arg Tyr Ser Tyr Lys Asp Ser Phe Gly Ser Ala Val Pro Arg Asn
705                 710                 715                 720 
Val Ser Gly Phe Pro Gln Tyr Pro Thr Gly Gln Glu Lys Gly Asp Phe
                725                 730                 735     
Thr Gly His Gly Glu Arg Lys Gly Arg Asn Glu Lys Phe Pro Ser Leu
            740                 745                 750         
Leu Gln Glu Val Leu Gln Gly Tyr His His His Pro Asp Arg Arg Tyr
        755                 760                 765             
Ser Arg Ser Thr Gln Glu His Gln Gly Met Ala Gly Ser Leu Glu Gly
    770                 775                 780                 
Thr Thr Arg Pro Asn Val Leu Val Ser Gln Thr Asn Glu Leu Ala Ser
785                 790                 795                 800 
Arg Gly Leu Leu Asn Lys Ser Ile Gly Ser Leu Leu Glu Asn Pro His
                805                 810                 815     
Trp Gly Pro Trp Glu Arg Lys Ser Ser Ser Thr Ala Pro Glu Met Lys
            820                 825                 830         
Gln Ile Asn Leu Thr Asp Tyr Pro Ile Pro Arg Lys Phe Glu Ile Glu
        835                 840                 845             
Pro Gln Ser Ser Ala His Glu Pro Gly Gly Ser Leu Ser Glu Arg Arg
    850                 855                 860                 
Ser Val Ile Cys Asp Ile Ser Pro Leu Arg Gln Ile Val Arg Asp Pro
865                 870                 875                 880 
Gly Ala His Ser Leu Gly His Met Ser Ala Asp Thr Arg Ile Gly Arg
                885                 890                 895     
Asn Asp Arg Leu Asn Pro Thr Leu Ser Gln Ser Val Ile Leu Pro Gly
            900                 905                 910         
Gly Leu Val Ser Met Glu Thr Lys Leu Lys Ser Gln Ser Gly Gln Ile
        915                 920                 925             
Lys Glu Glu Asp Phe Glu Gln Ser Lys Ser Gln Ala Ser Phe Asn Asn
    930                 935                 940                 
Lys Lys Ser Gly Asp His Cys His Pro Pro Ser Ile Lys His Glu Ser
945                 950                 955                 960 
Tyr Arg Gly Asn Ala Ser Pro Gly Ala Ala Thr His Asp Ser Leu Ser
                965                 970                 975     
Asp Tyr Gly Pro Gln Asp Ser Arg Pro Thr Pro Met Arg Arg Val Pro
            980                 985                 990         
Gly Arg Val Gly Gly Arg Glu Gly Met Arg Gly Arg Ser Pro Ser Gln
        995                 1000                1005            
Tyr His Asp Phe Ala Glu Lys Leu Lys Met Ser Pro Gly Arg Ser Arg
    1010                1015                1020                
Gly Pro Gly Gly Asp Pro His His Met Asn Pro His Met Thr Phe Ser
1025                1030                1035                1040
Glu Arg Ala Asn Arg Ser Ser Leu His Thr Pro Phe Ser Pro Asn Ser
                1045                1050                1055    
Glu Thr Leu Ala Ser Ala Tyr His Ala Asn Thr Arg Ala His Ala Tyr
            1060                1065                1070        
Gly Asp Pro Asn Ala Gly Leu Asn Ser Gln Leu His Tyr Lys Arg Gln
        1075                1080                1085            
Met Tyr Gln Gln Gln Pro Glu Glu Tyr Lys Asp Trp Ser Ser Gly Ser
    1090                1095                1100                
Ala Gln Gly Val Ile Ala Ala Ala Gln His Arg Gln Glu Gly Pro Arg
1105                1110                1115                1120
Lys Ser Pro Arg Gln Gln Gln Phe Leu Asp Arg Val Arg Ser Pro Leu
                1125                1130                1135    
Lys Asn Asp Lys Asp Gly Met Met Tyr Gly Pro Pro Val Gly Thr Tyr
            1140                1145                1150        
His Asp Pro Ser Ala Gln Glu Ala Gly Arg Cys Leu Met Ser Ser Asp
        1155                1160                1165            
Gly Leu Pro Asn Lys Gly Met Glu Leu Lys His Gly Ser Gln Lys Leu
    1170                1175                1180                
Gln Glu Ser Cys Trp Asp Leu Ser Arg Gln Thr Ser Pro Ala Lys Ser
1185                1190                1195                1200
Ser Gly Pro Pro Gly Met Ser Ser Gln Lys Arg Tyr Gly Pro Pro His
                1205                1210                1215    
Glu Thr Asp Gly His Gly Leu Ala Glu Ala Thr Gln Ser Ser Lys Pro
            1220                1225                1230        
Gly Ser Val Met Leu Arg Leu Pro Gly Gln Glu Asp His Ser Ser Gln
        1235                1240                1245            
Asn Pro Leu Ile Met Arg Arg Arg Val Arg Ser Phe Ile Ser Pro Ile
    1250                1255                1260                
Pro Ser Lys Arg Gln Ser Gln Asp Val Lys Asn Ser Ser Thr Glu Asp
1265                1270                1275                1280
Lys Gly Arg Leu Leu His Ser Ser Lys Glu Gly Ala Asp Lys Ala Phe
                1285                1290                1295    
Asn Ser Tyr Ala His Leu Ser His Ser Gln Asp Ile Lys Ser Ile Pro
            1300                1305                1310        
Lys Arg Asp Ser Ser Lys Asp Leu Pro Ser Pro Asp Ser Arg Asn Cys
        1315                1320                1325            
Pro Ala Val Thr Leu Thr Ser Pro Ala Lys Thr Lys Ile Leu Pro Pro
    1330                1335                1340                
Arg Lys Gly Arg Gly Leu Lys Leu Glu Ala Ile Val Gln Lys Ile Thr
1345                1350                1355                1360
Ser Pro Asn Ile Arg Arg Ser Ala Ser Ser Asn Ser Ala Glu Ala Gly
                1365                1370                1375    
Gly Asp Thr Val Thr Leu Asp Asp Ile Leu Ser Leu Lys Ser Gly Pro
            1380                1385                1390        
Pro Glu Gly Gly Ser Val Ala Val Gln Asp Ala Asp Ile Glu Lys Arg
        1395                1400                1405            
Lys Gly Glu Val Ala Ser Asp Leu Val Ser Pro Ala Asn Gln Glu Leu
    1410                1415                1420                
His Val Glu Lys Pro Leu Pro Arg Ser Ser Glu Glu Trp Arg Gly Ser
1425                1430                1435                1440
Val Asp Asp Lys Val Lys Thr Glu Thr His Ala Glu Thr Val Thr Ala
                1445                1450                1455    
Gly Lys Glu Pro Pro Gly Ala Met Thr Ser Thr Thr Ser Gln Lys Pro
            1460                1465                1470        
Gly Ser Asn Gln Gly Arg Pro Asp Gly Ser Leu Gly Gly Thr Ala Pro
        1475                1480                1485            
Leu Ile Phe Pro Asp Ser Lys Asn Val Pro Pro Val Gly Ile Leu Ala
    1490                1495                1500                
Pro Glu Ala Asn Pro Lys Ala Glu Glu Lys Glu Asn Asp Thr Val Thr
1505                1510                1515                1520
Ile Ser Pro Lys Gln Glu Gly Phe Pro Pro Lys Gly Tyr Phe Pro Ser
                1525                1530                1535    
Gly Lys Lys Lys Gly Arg Pro Ile Gly Ser Val Asn Lys Gln Lys Lys
            1540                1545                1550        
Gln Gln Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Ile Pro Glu
        1555                1560                1565            
Gly Ser Ala Asp Gly Glu Pro Lys Pro Lys Lys Gln Arg Gln Arg Arg
    1570                1575                1580                
Glu Arg Arg Lys Pro Gly Ala Gln Pro Arg Lys Arg Lys Thr Lys Gln
1585                1590                1595                1600
Ala Val Pro Ile Val Glu Pro Gln Glu Pro Glu Ile Lys Leu Lys Tyr
                1605                1610                1615    
Ala Thr Gln Pro Leu Asp Lys Thr Asp Ala Lys Asn Lys Ser Phe Tyr
            1620                1625                1630        
Pro Tyr Ile His Val Val Asn Lys Cys Glu Leu Gly Ala Val Cys Thr
        1635                1640                1645            
Ile Ile Asn Ala Glu Glu Glu Glu Gln Thr Lys Leu Val Arg Gly Arg
    1650                1655                1660                
Lys Gly Gln Arg Ser Leu Thr Pro Pro Pro Ser Ser Thr Glu Ser Lys
1665                1670                1675                1680
Ala Leu Pro Ala Ser Ser Phe Met Leu Gln Gly Pro Val Val Thr Glu
                1685                1690                1695    
Ser Ser Val Met Gly His Leu Val Cys Cys Leu Cys Gly Lys Trp Ala
            1700                1705                1710        
Ser Tyr Arg Asn Met Gly Asp Leu Phe Gly Pro Phe Tyr Pro Gln Asp
        1715                1720                1725            
Tyr Ala Ala Thr Leu Pro Lys Asn Pro Pro Pro Lys Arg Ala Thr Glu
    1730                1735                1740                
Met Gln Ser Lys Val Lys Val Arg His Lys Ser Ala Ser Asn Gly Ser
1745                1750                1755                1760
Lys Thr Asp Thr Glu Glu Glu Glu Glu Gln Gln Gln Gln Gln Lys Glu
                1765                1770                1775    
Gln Arg Ser Leu Ala Ala His Pro Arg Phe Lys Arg Arg His Arg Ser
            1780                1785                1790        
Glu Asp Cys Gly Gly Gly Pro Arg Ser Leu Ser Arg Gly Leu Pro Cys
        1795                1800                1805            
Lys Lys Ala Ala Thr Glu Gly Ser Ser Glu Lys Thr Val Leu Asp Ser
    1810                1815                1820                
Lys Pro Ser Val Pro Thr Thr Ser Glu Gly Gly Pro Glu Leu Glu Leu
1825                1830                1835                1840
Gln Ile Pro Glu Leu Pro Leu Asp Ser Asn Glu Phe Trp Val His Glu
                1845                1850                1855    
Gly Cys Ile Leu Trp Ala Asn Gly Ile Tyr Leu Val Cys Gly Arg Leu
            1860                1865                1870        
Tyr Gly Leu Gln Glu Ala Leu Glu Ile Ala Arg Glu Met Lys Cys Ser
        1875                1880                1885            
His Cys Gln Glu Ala Gly Ala Thr Leu Gly Cys Tyr Asn Lys Gly Cys
    1890                1895                1900                
Ser Phe Arg Tyr His Tyr Pro Cys Ala Ile Asp Ala Asp Cys Leu Leu
1905                1910                1915                1920
His Glu Glu Asn Phe Ser Val Arg Cys Pro Lys His Lys Pro Pro Leu
                1925                1930                1935    
Pro Cys Pro Leu Pro Pro Leu Gln Asn Lys Thr Ala Lys Gly Ser Leu
            1940                1945                1950        
Ser Thr Glu Gln Ser Glu Arg Gly
        1955                1960


<210> 6018
<211> 1938
<212> PRT
<213> Homo sapiens

<400> 6018
Met Gln Ser Phe Arg Glu Gln Ser Ser Tyr His Gly Asn Gln Gln Ser
 1               5                  10                  15      
Tyr Pro Gln Glu Val His Gly Ser Ser Arg Leu Glu Glu Phe Ser Pro
            20                  25                  30          
Arg Gln Ala Gln Met Phe Gln Asn Phe Gly Gly Thr Gly Gly Ser Ser
        35                  40                  45              
Gly Ser Ser Gly Ser Gly Ser Gly Gly Gly Arg Arg Gly Ala Ala Ala
    50                  55                  60                  
Ala Ala Ala Ala Met Ala Ser Glu Thr Ser Gly His Gln Gly Tyr Gln
65                  70                  75                  80  
Gly Phe Arg Lys Glu Ala Gly Asp Phe Tyr Tyr Met Ala Gly Asn Lys
                85                  90                  95      
Asp Pro Val Thr Thr Gly Thr Pro Gln Pro Pro Gln Arg Arg Pro Ser
            100                 105                 110         
Gly Pro Val Gln Ser Tyr Gly Pro Pro Arg Gly Ser Ser Phe Gly Asn
        115                 120                 125             
Gln Tyr Gly Ser Glu Gly His Val Gly Gln Phe Gln Ala Gln His Ser
    130                 135                 140                 
Gly Leu Gly Gly Val Ser His Tyr Gln Gln Asp Tyr Thr Gly Pro Phe
145                 150                 155                 160 
Ser Pro Gly Ser Ala Gln Tyr Gln Gln Gln Ala Ser Ser Gln Gln Gln
                165                 170                 175     
Gln Gln Gln Val Gln Gln Leu Arg Gln Gln Leu Tyr Gln Ser His Gln
            180                 185                 190         
Pro Leu Pro Gln Ala Thr Gly Lys Pro Ala Ser Ser Ser Ser His Leu
        195                 200                 205             
Gln Pro Met Gln Arg Pro Ser Thr Leu Pro Ser Ser Ala Ala Gly Tyr
    210                 215                 220                 
Gln Leu Arg Val Gly Gln Phe Gly Gln His Tyr Gln Ser Ser Ala Ser
225                 230                 235                 240 
Ser Ser Ser Ser Ser Ser Phe Pro Ser Pro Gln Arg Phe Ser Gln Ser
                245                 250                 255     
Gly Gln Ser Tyr Asp Gly Ser Tyr Asn Val Asn Ala Gly Ser Gln Tyr
            260                 265                 270         
Glu Gly His Asn Val Gly Ser Asn Ala Gln Ala Tyr Gly Thr Gln Ser
        275                 280                 285             
Asn Tyr Ser Tyr Gln Pro Gln Ser Met Lys Asn Phe Glu Gln Ala Lys
    290                 295                 300                 
Ile Pro Gln Gly Thr Gln Gln Gly Gln Gln Gln Gln Gln Pro Gln Gln
305                 310                 315                 320 
Gln Gln His Pro Ser Gln His Val Met Gln Tyr Thr Asn Ala Ala Thr
                325                 330                 335     
Lys Leu Pro Leu Gln Ser Gln Val Gly Gln Tyr Asn Gln Pro Glu Val
            340                 345                 350         
Pro Val Arg Ser Pro Met Gln Phe His Gln Asn Phe Ser Pro Ile Ser
        355                 360                 365             
Asn Pro Ser Pro Ala Ala Ser Val Val Gln Ser Pro Ser Cys Ser Ser
    370                 375                 380                 
Thr Pro Ser Pro Leu Met Gln Thr Gly Glu Asn Leu Gln Cys Gly Gln
385                 390                 395                 400 
Gly Ser Val Pro Met Gly Ser Arg Asn Arg Ile Leu Gln Leu Met Pro
                405                 410                 415     
Gln Leu Ser Pro Thr Pro Ser Met Met Pro Ser Pro Asn Ser His Ala
            420                 425                 430         
Ala Gly Phe Lys Gly Phe Gly Leu Glu Gly Val Pro Glu Lys Arg Leu
        435                 440                 445             
Thr Asp Pro Gly Leu Ser Ser Leu Ser Ala Leu Ser Thr Gln Val Ala
    450                 455                 460                 
Asn Leu Pro Asn Thr Val Gln His Met Leu Leu Ser Asp Ala Leu Thr
465                 470                 475                 480 
Pro Gln Lys Lys Thr Ser Lys Arg Pro Ser Ser Ser Lys Lys Ala Asp
                485                 490                 495     
Ser Cys Thr Asn Ser Glu Gly Ser Ser Gln Pro Glu Glu Gln Leu Lys
            500                 505                 510         
Ser Pro Met Ala Glu Ser Leu Asp Gly Gly Cys Ser Ser Ser Ser Glu
        515                 520                 525             
Asp Gln Gly Glu Arg Val Arg Gln Leu Ser Gly Gln Ser Thr Ser Ser
    530                 535                 540                 
Asp Thr Thr Tyr Lys Gly Gly Ala Ser Glu Lys Ala Gly Ser Ser Pro
545                 550                 555                 560 
Ala Gln Gly Ala Gln Asn Glu Pro Pro Arg Leu Asn Ala Ser Pro Ala
                565                 570                 575     
Ala Arg Glu Glu Ala Thr Ser Pro Gly Ala Lys Asp Met Pro Leu Ser
            580                 585                 590         
Ser Asp Gly Asn Pro Lys Val Asn Glu Lys Thr Val Gly Val Ile Val
        595                 600                 605             
Ser Arg Glu Ala Met Thr Gly Arg Val Glu Lys Pro Gly Gly Gln Asp
    610                 615                 620                 
Lys Gly Ser Gln Glu Asp Asp Pro Ala Ala Thr Gln Arg Pro Pro Ser
625                 630                 635                 640 
Asn Gly Gly Ala Lys Glu Thr Ser His Ala Ser Leu Pro Gln Pro Glu
                645                 650                 655     
Pro Pro Gly Gly Gly Gly Ser Lys Gly Asn Lys Asn Gly Asp Asn Asn
            660                 665                 670         
Ser Asn His Asn Gly Glu Gly Asn Gly Gln Ser Gly His Ser Ala Ala
        675                 680                 685             
Gly Pro Gly Phe Thr Ser Arg Thr Glu Pro Ser Lys Ser Pro Gly Ser
    690                 695                 700                 
Leu Arg Tyr Ser Tyr Lys Asp Ser Phe Gly Ser Ala Val Pro Arg Asn
705                 710                 715                 720 
Val Ser Gly Phe Pro Gln Tyr Pro Thr Gly Gln Glu Lys Gly Asp Phe
                725                 730                 735     
Thr Gly His Gly Glu Arg Lys Gly Arg Asn Glu Lys Phe Pro Ser Leu
            740                 745                 750         
Leu Gln Glu Val Leu Gln Gly Tyr His His His Pro Asp Arg Arg Tyr
        755                 760                 765             
Ser Arg Ser Thr Gln Glu His Gln Gly Met Ala Gly Ser Leu Glu Gly
    770                 775                 780                 
Thr Thr Arg Pro Asn Val Leu Val Ser Gln Thr Asn Glu Leu Ala Ser
785                 790                 795                 800 
Arg Gly Leu Leu Asn Lys Ser Ile Gly Ser Leu Leu Glu Asn Pro His
                805                 810                 815     
Trp Gly Pro Trp Glu Arg Lys Ser Ser Ser Thr Ala Pro Glu Met Lys
            820                 825                 830         
Gln Ile Asn Leu Thr Asp Tyr Pro Ile Pro Arg Lys Phe Glu Ile Glu
        835                 840                 845             
Pro Gln Ser Ser Ala His Glu Pro Gly Gly Ser Leu Ser Glu Arg Arg
    850                 855                 860                 
Ser Val Ile Cys Asp Ile Ser Pro Leu Arg Gln Ile Val Arg Asp Pro
865                 870                 875                 880 
Gly Ala His Ser Leu Gly His Met Ser Ala Asp Thr Arg Ile Gly Arg
                885                 890                 895     
Asn Asp Arg Leu Asn Pro Thr Leu Ser Gln Ser Val Ile Leu Pro Gly
            900                 905                 910         
Gly Leu Val Ser Met Glu Thr Lys Leu Lys Ser Gln Ser Gly Gln Ile
        915                 920                 925             
Lys Glu Glu Asp Phe Glu Gln Ser Lys Ser Gln Ala Ser Phe Asn Asn
    930                 935                 940                 
Lys Lys Ser Gly Asp His Cys His Pro Pro Ser Ile Lys His Glu Ser
945                 950                 955                 960 
Tyr Arg Gly Asn Ala Ser Pro Gly Ala Ala Thr His Asp Ser Leu Ser
                965                 970                 975     
Asp Tyr Gly Pro Gln Asp Ser Arg Pro Thr Pro Met Arg Arg Val Pro
            980                 985                 990         
Gly Arg Val Gly Gly Arg Glu Gly Met Arg Gly Arg Ser Pro Ser Gln
        995                 1000                1005            
Tyr His Asp Phe Ala Glu Lys Leu Lys Met Ser Pro Gly Arg Ser Arg
    1010                1015                1020                
Gly Pro Gly Gly Asp Pro His His Met Asn Pro His Met Thr Phe Ser
1025                1030                1035                1040
Glu Arg Ala Asn Arg Ser Ser Leu His Thr Pro Phe Ser Pro Asn Ser
                1045                1050                1055    
Glu Thr Leu Ala Ser Ala Tyr His Ala Asn Thr Arg Ala His Ala Tyr
            1060                1065                1070        
Gly Asp Pro Asn Ala Gly Leu Asn Ser Gln Leu His Tyr Lys Arg Gln
        1075                1080                1085            
Met Tyr Gln Gln Gln Pro Glu Glu Tyr Lys Asp Trp Ser Ser Gly Ser
    1090                1095                1100                
Ala Gln Gly Val Ile Ala Ala Ala Gln His Arg Gln Glu Gly Pro Arg
1105                1110                1115                1120
Lys Ser Pro Arg Gln Gln Gln Phe Leu Asp Arg Val Arg Ser Pro Leu
                1125                1130                1135    
Lys Asn Asp Lys Asp Gly Met Met Tyr Gly Pro Pro Val Gly Thr Tyr
            1140                1145                1150        
His Asp Pro Ser Ala Gln Glu Ala Gly Arg Cys Leu Met Ser Ser Asp
        1155                1160                1165            
Gly Leu Pro Asn Lys Gly Met Glu Leu Lys His Gly Ser Gln Lys Leu
    1170                1175                1180                
Gln Glu Ser Cys Trp Asp Leu Ser Arg Gln Thr Ser Pro Ala Lys Ser
1185                1190                1195                1200
Ser Gly Pro Pro Gly Met Ser Ser Gln Lys Arg Tyr Gly Pro Pro His
                1205                1210                1215    
Glu Thr Asp Gly His Gly Leu Ala Glu Ala Thr Gln Ser Ser Lys Pro
            1220                1225                1230        
Gly Ser Val Met Leu Arg Leu Pro Gly Gln Glu Asp His Ser Ser Gln
        1235                1240                1245            
Asn Pro Leu Ile Met Arg Arg Arg Val Arg Ser Phe Ile Ser Pro Ile
    1250                1255                1260                
Pro Ser Lys Arg Gln Ser Gln Asp Val Lys Asn Ser Ser Thr Glu Asp
1265                1270                1275                1280
Lys Gly Arg Leu Leu His Ser Ser Lys Glu Gly Ala Asp Lys Ala Phe
                1285                1290                1295    
Asn Ser Tyr Ala His Leu Ser His Ser Gln Asp Ile Lys Ser Ile Pro
            1300                1305                1310        
Lys Arg Asp Ser Ser Lys Asp Leu Pro Ser Pro Asp Ser Arg Asn Cys
        1315                1320                1325            
Pro Ala Val Thr Leu Thr Ser Pro Ala Lys Thr Lys Ile Leu Pro Pro
    1330                1335                1340                
Arg Lys Gly Arg Gly Leu Lys Leu Glu Ala Ile Val Gln Lys Ile Thr
1345                1350                1355                1360
Ser Pro Asn Ile Arg Arg Ser Ala Ser Ser Asn Ser Ala Glu Ala Gly
                1365                1370                1375    
Gly Asp Thr Val Thr Leu Asp Asp Ile Leu Ser Leu Lys Ser Gly Pro
            1380                1385                1390        
Pro Glu Gly Gly Ser Val Ala Val Gln Asp Ala Asp Ile Glu Lys Arg
        1395                1400                1405            
Lys Gly Glu Val Ala Ser Asp Leu Val Ser Pro Ala Asn Gln Glu Leu
    1410                1415                1420                
His Val Glu Lys Pro Leu Pro Arg Ser Ser Glu Glu Trp Arg Gly Ser
1425                1430                1435                1440
Val Asp Asp Lys Val Lys Thr Glu Thr His Ala Glu Thr Val Thr Ala
                1445                1450                1455    
Gly Lys Glu Pro Pro Gly Ala Met Thr Ser Thr Thr Ser Gln Lys Pro
            1460                1465                1470        
Gly Ser Asn Gln Gly Arg Pro Asp Gly Ser Leu Gly Gly Thr Ala Pro
        1475                1480                1485            
Leu Ile Phe Pro Asp Ser Lys Asn Val Pro Pro Val Gly Ile Leu Ala
    1490                1495                1500                
Pro Glu Ala Asn Pro Lys Ala Glu Glu Lys Glu Asn Asp Thr Val Thr
1505                1510                1515                1520
Ile Ser Pro Lys Gln Glu Gly Phe Pro Pro Lys Gly Tyr Phe Pro Ser
                1525                1530                1535    
Gly Lys Lys Lys Gly Arg Pro Ile Gly Ser Val Asn Lys Gln Lys Lys
            1540                1545                1550        
Gln Gln Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Ile Pro Glu
        1555                1560                1565            
Gly Ser Ala Asp Gly Glu Pro Lys Pro Lys Lys Gln Arg Gln Arg Arg
    1570                1575                1580                
Glu Arg Arg Lys Pro Gly Ala Gln Pro Arg Lys Arg Lys Thr Lys Gln
1585                1590                1595                1600
Ala Val Pro Ile Val Glu Pro Gln Glu Pro Glu Ile Lys Leu Lys Tyr
                1605                1610                1615    
Ala Thr Gln Pro Leu Asp Lys Thr Asp Ala Lys Asn Lys Ser Phe Tyr
            1620                1625                1630        
Pro Tyr Ile His Val Val Asn Lys Cys Glu Leu Gly Ala Val Cys Thr
        1635                1640                1645            
Ile Ile Asn Ala Glu Glu Glu Glu Gln Thr Lys Leu Val Arg Gly Arg
    1650                1655                1660                
Lys Gly Gln Arg Ser Leu Thr Pro Pro Pro Ser Ser Thr Glu Ser Lys
1665                1670                1675                1680
Ala Leu Pro Ala Ser Ser Phe Met Leu Gln Gly Pro Val Val Thr Glu
                1685                1690                1695    
Ser Ser Val Met Gly His Leu Val Cys Cys Leu Cys Gly Lys Trp Ala
            1700                1705                1710        
Ser Tyr Arg Asn Met Gly Asp Leu Phe Gly Pro Phe Tyr Pro Gln Asp
        1715                1720                1725            
Tyr Ala Ala Thr Leu Pro Lys Asn Pro Pro Pro Lys Arg Ala Thr Glu
    1730                1735                1740                
Met Gln Ser Lys Val Lys Val Arg His Lys Ser Ala Ser Asn Gly Ser
1745                1750                1755                1760
Lys Thr Asp Thr Glu Glu Glu Glu Glu Gln Gln Gln Gln Gln Lys Glu
                1765                1770                1775    
Gln Arg Ser Leu Ala Ala His Pro Arg Phe Lys Arg Arg His Arg Ser
            1780                1785                1790        
Glu Asp Cys Gly Gly Gly Pro Arg Ser Leu Ser Arg Gly Leu Pro Cys
        1795                1800                1805            
Lys Lys Ala Ala Thr Glu Gly Ser Ser Glu Lys Thr Val Leu Asp Ser
    1810                1815                1820                
Lys Pro Ser Val Pro Thr Thr Ser Glu Gly Gly Pro Glu Leu Glu Leu
1825                1830                1835                1840
Gln Ile Pro Glu Leu Pro Leu Asp Ser Asn Glu Phe Trp Val His Glu
                1845                1850                1855    
Gly Cys Ile Leu Trp Ala Asn Gly Ile Tyr Leu Val Cys Gly Arg Leu
            1860                1865                1870        
Tyr Gly Leu Gln Glu Ala Leu Glu Ile Ala Arg Glu Met Lys Cys Ser
        1875                1880                1885            
His Cys Gln Glu Ala Gly Ala Thr Leu Gly Cys Tyr Asn Lys Gly Cys
    1890                1895                1900                
Ser Phe Arg Tyr His Tyr Pro Cys Ala Ile Asp Ala Asp Cys Leu Leu
1905                1910                1915                1920
His Glu Glu Asn Phe Ser Val Arg Cys Pro Lys His Lys Val Arg Leu
                1925                1930                1935    
Trp Arg
        


<210> 6019
<211> 320
<212> PRT
<213> Homo sapiens

<400> 6019
Met Leu Arg Arg Leu Arg Lys Gly Asn Leu Pro Ile Arg Ser Ile Ile
 1               5                  10                  15      
Pro Asn His Ala Asp Lys Glu Arg Phe Ala Thr Arg Cys Lys Ala Ala
            20                  25                  30          
Thr Val Leu Leu Tyr Asp Glu Ala Thr Ala Glu Trp Gln Pro Glu Pro
        35                  40                  45              
Gly Ala Pro Ala Ser Val Leu Gly Leu Leu Leu Gln Lys Leu Arg Asp
    50                  55                  60                  
Asp Gly Cys Gln Ala Tyr Tyr Leu Gln Gly Gly Phe Asn Lys Phe Gln
65                  70                  75                  80  
Thr Glu Tyr Ser Glu His Cys Glu Thr Asn Val Asp Ser Ser Ser Ser
                85                  90                  95      
Pro Ser Ser Ser Pro Pro Thr Ser Val Leu Gly Leu Gly Gly Leu Arg
            100                 105                 110         
Ile Ser Ser Asp Cys Ser Asp Gly Glu Ser Asp Arg Glu Leu Pro Ser
        115                 120                 125             
Ser Ala Thr Glu Ser Asp Gly Ser Pro Val Pro Ser Ser Gln Pro Ala
    130                 135                 140                 
Phe Pro Val Gln Ile Leu Pro Tyr Leu Tyr Leu Gly Cys Ala Lys Asp
145                 150                 155                 160 
Ser Thr Asn Leu Asp Val Leu Gly Lys Tyr Gly Ile Lys Tyr Ile Leu
                165                 170                 175     
Asn Val Thr Pro Asn Leu Pro Asn Ala Phe Glu His Gly Gly Glu Phe
            180                 185                 190         
Thr Tyr Lys Gln Ile Pro Ile Ser Asp His Trp Ser Gln Asn Leu Ser
        195                 200                 205             
Gln Phe Phe Pro Glu Ala Ile Ser Phe Ile Asp Glu Ala Arg Ser Lys
    210                 215                 220                 
Lys Cys Gly Val Leu Val His Cys Leu Ala Gly Ile Ser Arg Ser Val
225                 230                 235                 240 
Thr Val Thr Val Ala Tyr Leu Met Gln Lys Met Asn Leu Ser Leu Asn
                245                 250                 255     
Asp Ala Tyr Asp Phe Val Lys Arg Lys Lys Ser Asn Ile Ser Pro Asn
            260                 265                 270         
Phe Asn Phe Met Gly Gln Leu Leu Asp Phe Glu Arg Thr Leu Gly Leu
        275                 280                 285             
Ser Ser Pro Cys Asp Asn His Ala Ser Ser Glu Gln Leu Tyr Phe Ser
    290                 295                 300                 
Thr Pro Thr Asn His Asn Leu Phe Pro Leu Asn Thr Leu Glu Ser Thr
305                 310                 315                 320 


<210> 6020
<211> 419
<212> PRT
<213> Homo sapiens

<400> 6020
Met Lys Asn Gln Leu Arg Gly Pro Pro Ala Arg Ala His Met Ser Thr
 1               5                  10                  15      
Ser Gly Ala Ala Ala Ala Gly Gly Thr Arg Ala Gly Ser Glu Pro Gly
            20                  25                  30          
Ala Gly Ser Gly Ser Gly Ala Gly Thr Gly Ala Gly Ala Ala Thr Gly
        35                  40                  45              
Ala Gly Ala Met Pro Cys Lys Ser Ala Glu Trp Leu Gln Glu Glu Leu
    50                  55                  60                  
Glu Ala Arg Gly Gly Ala Ser Leu Leu Leu Leu Asp Cys Arg Pro His
65                  70                  75                  80  
Glu Leu Phe Glu Ser Ser His Ile Glu Thr Ala Ile Asn Leu Ala Ile
                85                  90                  95      
Pro Gly Leu Met Leu Arg Arg Leu Arg Lys Gly Asn Leu Pro Ile Arg
            100                 105                 110         
Ser Ile Ile Pro Asn His Ala Asp Lys Glu Arg Phe Ala Thr Arg Cys
        115                 120                 125             
Lys Ala Ala Thr Val Leu Leu Tyr Asp Glu Ala Thr Ala Glu Trp Gln
    130                 135                 140                 
Pro Glu Pro Gly Ala Pro Ala Ser Val Leu Gly Leu Leu Leu Gln Lys
145                 150                 155                 160 
Leu Arg Asp Asp Gly Cys Gln Ala Tyr Tyr Leu Gln Gly Gly Phe Asn
                165                 170                 175     
Lys Phe Gln Thr Glu Tyr Ser Glu His Cys Glu Thr Asn Val Asp Ser
            180                 185                 190         
Ser Ser Ser Pro Ser Ser Ser Pro Pro Thr Ser Val Leu Gly Leu Gly
        195                 200                 205             
Gly Leu Arg Ile Ser Ser Asp Cys Ser Asp Gly Glu Ser Asp Arg Glu
    210                 215                 220                 
Leu Pro Ser Ser Ala Thr Glu Ser Asp Gly Ser Pro Val Pro Ser Ser
225                 230                 235                 240 
Gln Pro Ala Phe Pro Val Gln Ile Leu Pro Tyr Leu Tyr Leu Gly Cys
                245                 250                 255     
Ala Lys Asp Ser Thr Asn Leu Asp Val Leu Gly Lys Tyr Gly Ile Lys
            260                 265                 270         
Tyr Ile Leu Asn Val Thr Pro Asn Leu Pro Asn Ala Phe Glu His Gly
        275                 280                 285             
Gly Glu Phe Thr Tyr Lys Gln Ile Pro Ile Ser Asp His Trp Ser Gln
    290                 295                 300                 
Asn Leu Ser Gln Phe Phe Pro Glu Ala Ile Ser Phe Ile Asp Glu Ala
305                 310                 315                 320 
Arg Ser Lys Lys Cys Gly Val Leu Val His Cys Leu Ala Gly Ile Ser
                325                 330                 335     
Arg Ser Val Thr Val Thr Val Ala Tyr Leu Met Gln Lys Met Asn Leu
            340                 345                 350         
Ser Leu Asn Asp Ala Tyr Asp Phe Val Lys Arg Lys Lys Ser Asn Ile
        355                 360                 365             
Ser Pro Asn Phe Asn Phe Met Gly Gln Leu Leu Asp Phe Glu Arg Thr
    370                 375                 380                 
Leu Gly Leu Ser Ser Pro Cys Asp Asn His Ala Ser Ser Glu Gln Leu
385                 390                 395                 400 
Tyr Phe Ser Thr Pro Thr Asn His Asn Leu Phe Pro Leu Asn Thr Leu
                405                 410                 415     
Glu Ser Thr
            


<210> 6021
<211> 235
<212> PRT
<213> Homo sapiens

<400> 6021
Met Ile Asp Thr Leu Arg Pro Val Pro Phe Ala Ser Glu Met Ala Ile
 1               5                  10                  15      
Ser Lys Thr Val Ala Trp Leu Asn Glu Gln Leu Glu Leu Gly Asn Glu
            20                  25                  30          
Arg Leu Leu Leu Met Asp Cys Arg Pro Gln Glu Leu Tyr Glu Ser Ser
        35                  40                  45              
His Ile Glu Ser Ala Ile Asn Val Ala Ile Pro Gly Ile Met Leu Arg
    50                  55                  60                  
Arg Leu Gln Lys Gly Asn Leu Pro Val Arg Ala Leu Phe Thr Arg Gly
65                  70                  75                  80  
Glu Asp Arg Asp Arg Phe Thr Arg Arg Cys Gly Thr Asp Thr Val Val
                85                  90                  95      
Leu Tyr Asp Glu Ser Ser Ser Asp Trp Asn Glu Asn Thr Gly Gly Glu
            100                 105                 110         
Ser Leu Leu Gly Leu Leu Leu Lys Lys Leu Lys Asp Glu Gly Cys Arg
        115                 120                 125             
Ala Phe Tyr Leu Glu Asp Glu Ala Arg Gly Lys Asn Cys Gly Val Leu
    130                 135                 140                 
Val His Cys Leu Ala Gly Ile Ser Arg Ser Val Thr Val Thr Val Ala
145                 150                 155                 160 
Tyr Leu Met Gln Lys Leu Asn Leu Ser Met Asn Asp Ala Tyr Asp Ile
                165                 170                 175     
Val Lys Met Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly
            180                 185                 190         
Gln Leu Leu Asp Phe Glu Arg Thr Leu Gly Leu Ser Ser Pro Cys Asp
        195                 200                 205             
Asn Arg Val Pro Ala Gln Gln Leu Tyr Phe Thr Thr Pro Ser Asn Gln
    210                 215                 220                 
Asn Val Tyr Gln Val Asp Ser Leu Gln Ser Thr
225                 230                 235 


<210> 6022
<211> 381
<212> PRT
<213> Homo sapiens

<400> 6022
Met Ile Asp Thr Leu Arg Pro Val Pro Phe Ala Ser Glu Met Ala Ile
 1               5                  10                  15      
Ser Lys Thr Val Ala Trp Leu Asn Glu Gln Leu Glu Leu Gly Asn Glu
            20                  25                  30          
Arg Leu Leu Leu Met Asp Cys Arg Pro Gln Glu Leu Tyr Glu Ser Ser
        35                  40                  45              
His Ile Glu Ser Ala Ile Asn Val Ala Ile Pro Gly Ile Met Leu Arg
    50                  55                  60                  
Arg Leu Gln Lys Gly Asn Leu Pro Val Arg Ala Leu Phe Thr Arg Gly
65                  70                  75                  80  
Glu Asp Arg Asp Arg Phe Thr Arg Arg Cys Gly Thr Asp Thr Val Val
                85                  90                  95      
Leu Tyr Asp Glu Ser Ser Ser Asp Trp Asn Glu Asn Thr Gly Gly Glu
            100                 105                 110         
Ser Leu Leu Gly Leu Leu Leu Lys Lys Leu Lys Asp Glu Gly Cys Arg
        115                 120                 125             
Ala Phe Tyr Leu Glu Gly Gly Phe Ser Lys Phe Gln Ala Glu Phe Ser
    130                 135                 140                 
Leu His Cys Glu Thr Asn Leu Asp Gly Ser Cys Ser Ser Ser Ser Pro
145                 150                 155                 160 
Pro Leu Pro Val Leu Gly Leu Gly Gly Leu Arg Ile Ser Ser Asp Ser
                165                 170                 175     
Ser Ser Asp Ile Glu Ser Asp Leu Asp Arg Asp Pro Asn Ser Ala Thr
            180                 185                 190         
Asp Ser Asp Gly Ser Pro Leu Ser Asn Ser Gln Pro Ser Phe Pro Val
        195                 200                 205             
Glu Ile Leu Pro Phe Leu Tyr Leu Gly Cys Ala Lys Asp Ser Thr Asn
    210                 215                 220                 
Leu Asp Val Leu Glu Glu Phe Gly Ile Lys Tyr Ile Leu Asn Val Thr
225                 230                 235                 240 
Pro Asn Leu Pro Asn Leu Phe Glu Asn Ala Gly Glu Phe Lys Tyr Lys
                245                 250                 255     
Gln Ile Pro Ile Ser Asp His Trp Ser Gln Asn Leu Ser Gln Phe Phe
            260                 265                 270         
Pro Glu Ala Ile Ser Phe Ile Asp Glu Ala Arg Gly Lys Asn Cys Gly
        275                 280                 285             
Val Leu Val His Cys Leu Ala Gly Ile Ser Arg Ser Val Thr Val Thr
    290                 295                 300                 
Val Ala Tyr Leu Met Gln Lys Leu Asn Leu Ser Met Asn Asp Ala Tyr
305                 310                 315                 320 
Asp Ile Val Lys Met Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe
                325                 330                 335     
Met Gly Gln Leu Leu Asp Phe Glu Arg Thr Leu Gly Leu Ser Ser Pro
            340                 345                 350         
Cys Asp Asn Arg Val Pro Ala Gln Gln Leu Tyr Phe Thr Thr Pro Ser
        355                 360                 365             
Asn Gln Asn Val Tyr Gln Val Asp Ser Leu Gln Ser Thr
    370                 375                 380     


<210> 6023
<211> 1061
<212> PRT
<213> Homo sapiens

<400> 6023
Met Thr Thr Val Val Val His Val Asp Ser Lys Ala Glu Leu Thr Thr
 1               5                  10                  15      
Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val
            20                  25                  30          
Pro Ile Leu Thr Arg Met Ser Gln Leu Ile Glu Lys Glu Thr Glu Glu
        35                  40                  45              
Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg
    50                  55                  60                  
Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys
65                  70                  75                  80  
Asn Asp Asp Phe Met Asn Ala Leu Val Asn Ala Tyr Val Met Thr Ser
                85                  90                  95      
Arg Glu Pro Pro Leu Asn Thr Ala Ala Cys Arg Leu Leu Leu Asp Ile
            100                 105                 110         
Met Pro Gly Leu Glu Thr Ala Val Val Phe Gln Glu Lys Glu Gly Ile
        115                 120                 125             
Val Glu Asn Leu Phe Lys Trp Ala Arg Glu Ala Asp Gln Pro Leu Arg
    130                 135                 140                 
Thr Tyr Ser Thr Gly Leu Leu Gly Gly Ala Met Glu Asn Gln Asp Ile
145                 150                 155                 160 
Ala Ala Asn Tyr Arg Asp Glu Asn Ser Gln Leu Val Ala Ile Val Leu
                165                 170                 175     
Arg Arg Leu Arg Glu Leu Gln Leu Gln Glu Val Ala Leu Arg Gln Glu
            180                 185                 190         
Asn Lys Arg Pro Ser Pro Arg Lys Leu Ser Ser Glu Pro Leu Leu Pro
        195                 200                 205             
Leu Asp Glu Glu Ala Val Asp Met Asp Tyr Val Ala Glu Gly Glu Phe
    210                 215                 220                 
Phe Ile His Asp Ala Glu Ile Gln Lys Ser Ala Leu Gln Ile Ile Ile
225                 230                 235                 240 
Asn Cys Val Cys Gly Pro Asp Asn Arg Ile Ser Ser Ile Gly Lys Phe
                245                 250                 255     
Ile Ser Gly Thr Pro Arg Arg Lys Leu Pro Gln Asn Pro Lys Ser Ser
            260                 265                 270         
Glu His Thr Leu Ala Lys Met Trp Asn Val Val Gln Ser Asn Asn Gly
        275                 280                 285             
Ile Lys Val Leu Leu Ser Leu Leu Ser Ile Lys Met Pro Ile Thr Asp
    290                 295                 300                 
Ala Asp Gln Ile Arg Ala Leu Ala Cys Lys Ala Leu Val Gly Leu Ser
305                 310                 315                 320 
Arg Ser Ser Thr Val Arg Gln Ile Ile Ser Lys Leu Pro Leu Phe Ser
                325                 330                 335     
Ser Cys Gln Ile Gln Gln Leu Met Lys Glu Pro Val Leu Gln Asp Lys
            340                 345                 350         
Arg Ser Asp His Val Lys Phe Cys Lys Tyr Ala Ala Glu Leu Ile Glu
        355                 360                 365             
Arg Val Ser Gly Lys Pro Leu Leu Ile Gly Thr Asp Val Ser Leu Ala
    370                 375                 380                 
Arg Leu Gln Lys Ala Asp Val Val Ala Gln Ser Arg Ile Ser Phe Pro
385                 390                 395                 400 
Glu Lys Glu Leu Leu Leu Leu Ile Arg Asn His Leu Ile Ser Lys Gly
                405                 410                 415     
Leu Gly Glu Thr Ala Thr Val Leu Thr Lys Glu Ala Asp Leu Pro Met
            420                 425                 430         
Thr Ala Ala Ser His Ser Ser Ala Phe Thr Pro Val Thr Ala Ala Ala
        435                 440                 445             
Ser Pro Val Ser Leu Pro Arg Thr Pro Arg Ile Ala Asn Gly Ile Ala
    450                 455                 460                 
Thr Arg Leu Gly Ser His Ala Ala Val Gly Ala Ser Ala Pro Ser Ala
465                 470                 475                 480 
Pro Thr Ala His Pro Gln Pro Arg Pro Pro Gln Gly Pro Leu Ala Leu
                485                 490                 495     
Pro Gly Pro Ser Tyr Ala Gly Asn Ser Pro Leu Ile Gly Arg Ile Ser
            500                 505                 510         
Phe Ile Arg Glu Arg Pro Ser Pro Cys Asn Gly Arg Lys Ile Arg Val
        515                 520                 525             
Leu Arg Gln Lys Ser Asp His Gly Ala Tyr Ser Gln Ser Pro Ala Ile
    530                 535                 540                 
Lys Lys Gln Leu Asp Arg His Leu Pro Ser Pro Pro Thr Leu Asp Ser
545                 550                 555                 560 
Ile Ile Thr Glu Tyr Leu Arg Glu Gln His Ala Arg Cys Lys Asn Pro
                565                 570                 575     
Val Ala Thr Cys Pro Pro Phe Ser Leu Phe Thr Pro His Gln Cys Pro
            580                 585                 590         
Glu Pro Lys Gln Arg Arg Gln Ala Pro Ile Asn Phe Thr Ser Arg Leu
        595                 600                 605             
Asn Arg Arg Ala Ser Phe Pro Lys Tyr Gly Gly Val Asp Gly Gly Cys
    610                 615                 620                 
Phe Asp Arg His Leu Ile Phe Ser Arg Phe Arg Pro Ile Ser Val Phe
625                 630                 635                 640 
Arg Glu Ala Asn Glu Asp Glu Ser Gly Phe Thr Cys Cys Ala Phe Ser
                645                 650                 655     
Ala Arg Glu Arg Phe Leu Met Leu Gly Thr Cys Thr Gly Gln Leu Lys
            660                 665                 670         
Leu Tyr Asn Val Phe Ser Gly Gln Glu Glu Ala Ser Tyr Asn Cys His
        675                 680                 685             
Asn Ser Ala Ile Thr His Leu Glu Pro Ser Arg Asp Gly Ser Leu Leu
    690                 695                 700                 
Leu Thr Ser Ala Thr Trp Ser Gln Pro Leu Ser Ala Leu Trp Gly Met
705                 710                 715                 720 
Lys Ser Val Phe Asp Met Lys His Ser Phe Thr Glu Asp His Tyr Val
                725                 730                 735     
Glu Phe Ser Lys His Ser Gln Asp Arg Val Ile Gly Thr Lys Gly Asp
            740                 745                 750         
Ile Ala His Ile Tyr Asp Ile Gln Thr Gly Asn Lys Leu Leu Thr Leu
        755                 760                 765             
Phe Asn Pro Asp Leu Ala Asn Asn Tyr Lys Arg Asn Cys Ala Thr Phe
    770                 775                 780                 
Asn Pro Thr Asp Asp Leu Val Leu Asn Asp Gly Val Leu Trp Asp Val
785                 790                 795                 800 
Arg Ser Ala Gln Ala Ile His Lys Phe Asp Lys Phe Asn Met Asn Ile
                805                 810                 815     
Ser Gly Val Phe His Pro Asn Gly Leu Glu Val Ile Ile Asn Thr Glu
            820                 825                 830         
Ile Trp Asp Leu Arg Thr Phe His Leu Leu His Thr Val Pro Ala Leu
        835                 840                 845             
Asp Gln Cys Arg Val Val Phe Asn His Thr Gly Thr Val Met Tyr Gly
    850                 855                 860                 
Ala Met Leu Gln Ala Asp Asp Glu Asp Asp Leu Met Glu Glu Arg Met
865                 870                 875                 880 
Lys Ser Pro Phe Gly Ser Ser Phe Arg Thr Phe Asn Ala Thr Asp Tyr
                885                 890                 895     
Lys Pro Ile Ala Thr Ile Asp Val Lys Arg Asn Ile Phe Asp Leu Cys
            900                 905                 910         
Thr Asp Thr Lys Asp Cys Tyr Leu Ala Val Ile Glu Asn Gln Gly Ser
        915                 920                 925             
Met Asp Ala Leu Asn Met Asp Thr Val Cys Arg Leu Tyr Glu Val Gly
    930                 935                 940                 
Arg Gln Arg Leu Ala Glu Asp Glu Asp Glu Glu Glu Asp Gln Glu Glu
945                 950                 955                 960 
Glu Glu Gln Glu Glu Glu Asp Asp Asp Glu Asp Asp Asp Asp Thr Asp
                965                 970                 975     
Asp Leu Asp Glu Leu Asp Thr Asp Gln Leu Leu Glu Ala Glu Leu Glu
            980                 985                 990         
Glu Asp Asp Asn Asn Glu Asn Ala Gly Glu Asp Gly Asp Asn Asp Phe
        995                 1000                1005            
Ser Pro Ser Asp Glu Glu Leu Ala Asn Leu Leu Glu Glu Gly Glu Asp
    1010                1015                1020                
Gly Glu Asp Glu Asp Ser Asp Ala Asp Glu Glu Val Glu Leu Ile Leu
1025                1030                1035                1040
Gly Asp Thr Asp Ser Ser Asp Asn Ser Asp Leu Glu Asp Asp Ile Ile
                1045                1050                1055    
Leu Ser Leu Asn Glu
            1060    


<210> 6024
<211> 1511
<212> PRT
<213> Homo sapiens

<400> 6024
Met Thr Thr Val Val Val His Val Asp Ser Lys Ala Glu Leu Thr Thr
 1               5                  10                  15      
Leu Leu Glu Gln Trp Glu Lys Glu His Gly Ser Gly Gln Asp Met Val
            20                  25                  30          
Pro Ile Leu Thr Arg Met Ser Gln Leu Ile Glu Lys Glu Thr Glu Glu
        35                  40                  45              
Tyr Arg Lys Gly Asp Pro Asp Pro Phe Asp Asp Arg His Pro Gly Arg
    50                  55                  60                  
Ala Asp Pro Glu Cys Met Leu Gly His Leu Leu Arg Ile Leu Phe Lys
65                  70                  75                  80  
Asn Asp Asp Phe Met Asn Ala Leu Val Asn Ala Tyr Val Met Thr Ser
                85                  90                  95      
Arg Glu Pro Pro Leu Asn Thr Ala Ala Cys Arg Leu Leu Leu Asp Ile
            100                 105                 110         
Met Pro Gly Leu Glu Thr Ala Val Val Phe Gln Glu Lys Glu Gly Ile
        115                 120                 125             
Val Glu Asn Leu Phe Lys Trp Ala Arg Glu Ala Asp Gln Pro Leu Arg
    130                 135                 140                 
Thr Tyr Ser Thr Gly Leu Leu Gly Gly Ala Met Glu Asn Gln Asp Ile
145                 150                 155                 160 
Ala Ala Asn Tyr Arg Asp Glu Asn Ser Gln Leu Val Ala Ile Val Leu
                165                 170                 175     
Arg Arg Leu Arg Glu Leu Gln Leu Gln Glu Val Ala Leu Arg Gln Glu
            180                 185                 190         
Asn Lys Arg Pro Ser Pro Arg Lys Leu Ser Ser Glu Pro Leu Leu Pro
        195                 200                 205             
Leu Asp Glu Glu Ala Val Asp Met Asp Tyr Gly Asp Met Ala Val Asp
    210                 215                 220                 
Val Val Asp Gly Asp Gln Glu Glu Ala Ser Gly Asp Met Glu Ile Ser
225                 230                 235                 240 
Phe His Leu Asp Ser Gly His Lys Thr Ser Ser Arg Val Asn Ser Thr
                245                 250                 255     
Thr Lys Pro Glu Asp Gly Gly Leu Lys Lys Asn Lys Ser Ala Lys Gln
            260                 265                 270         
Gly Asp Arg Glu Asn Phe Arg Lys Ala Lys Gln Lys Leu Gly Phe Ser
        275                 280                 285             
Ser Ser Asp Pro Asp Arg Met Phe Val Glu Leu Ser Asn Ser Ser Trp
    290                 295                 300                 
Ser Glu Met Ser Pro Trp Val Ile Gly Thr Asn Tyr Thr Leu Tyr Pro
305                 310                 315                 320 
Met Thr Pro Ala Ile Glu Gln Arg Leu Ile Leu Gln Tyr Leu Thr Pro
                325                 330                 335     
Leu Gly Glu Tyr Gln Glu Leu Leu Pro Ile Phe Met Gln Leu Gly Ser
            340                 345                 350         
Arg Glu Leu Met Met Phe Tyr Ile Asp Leu Lys Gln Thr Asn Asp Val
        355                 360                 365             
Leu Leu Thr Phe Glu Ala Leu Lys Val Lys Phe Leu Lys Ile Leu Gly
    370                 375                 380                 
His Arg Gly Phe Phe Lys Asn Phe Val Phe Phe Asn Leu Arg Trp Ser
385                 390                 395                 400 
Leu Thr Leu Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile Leu Ala His
                405                 410                 415     
Cys Asn Leu Arg Leu Leu Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser
            420                 425                 430         
Arg Val Cys Met His Pro His Asn Val Leu Ser Asp Val Val Asn Tyr
        435                 440                 445             
Thr Leu Trp Leu Met Glu Cys Ser His Ala Ser Gly Cys Cys His Ala
    450                 455                 460                 
Thr Met Phe Phe Ser Ile Cys Phe Ser Phe Arg Ala Val Leu Glu Leu
465                 470                 475                 480 
Phe Asp Arg Tyr Asp Gly Leu Arg Arg Leu Val Asn Leu Val Ser Thr
                485                 490                 495     
Leu Glu Ile Leu Asn Leu Glu Asp Gln Gly Ala Leu Leu Ser Asp Asp
            500                 505                 510         
Glu Ile Phe Ala Ser Arg Gln Thr Gly Lys His Thr Cys Met Ala Leu
        515                 520                 525             
Arg Lys Tyr Phe Glu Ala His Leu Ala Ile Lys Leu Glu Gln Val Lys
    530                 535                 540                 
Gln Ser Leu Gln Arg Thr Glu Gly Gly Ile Leu Val His Pro Gln Pro
545                 550                 555                 560 
Pro Tyr Lys Ala Cys Ser Tyr Thr His Glu Gln Ile Val Glu Met Met
                565                 570                 575     
Glu Phe Leu Ile Glu Tyr Gly Pro Ala Gln Leu Tyr Trp Glu Pro Ala
            580                 585                 590         
Glu Val Phe Leu Lys Leu Ser Cys Val Gln Leu Leu Leu Gln Leu Ile
        595                 600                 605             
Ser Ile Ala Cys Asn Trp Lys Thr Tyr Tyr Ala Arg Asn Asp Thr Val
    610                 615                 620                 
Arg Phe Ala Leu Asp Val Leu Ala Ile Leu Thr Val Val Pro Lys Ile
625                 630                 635                 640 
Gln Leu Gln Leu Ala Glu Ser Val Asp Val Leu Asp Glu Ala Gly Ser
                645                 650                 655     
Thr Val Ser Thr Val Gly Ile Ser Ile Ile Leu Gly Val Ala Glu Gly
            660                 665                 670         
Glu Phe Phe Ile His Asp Ala Glu Ile Gln Lys Ser Ala Leu Gln Ile
        675                 680                 685             
Ile Ile Asn Cys Val Cys Gly Pro Asp Asn Arg Ile Ser Ser Ile Gly
    690                 695                 700                 
Lys Phe Ile Ser Gly Thr Pro Arg Arg Lys Leu Pro Gln Asn Pro Lys
705                 710                 715                 720 
Ser Ser Glu His Thr Leu Ala Lys Met Trp Asn Val Val Gln Ser Asn
                725                 730                 735     
Asn Gly Ile Lys Val Leu Leu Ser Leu Leu Ser Ile Lys Met Pro Ile
            740                 745                 750         
Thr Asp Ala Asp Gln Ile Arg Ala Leu Ala Cys Lys Ala Leu Val Gly
        755                 760                 765             
Leu Ser Arg Ser Ser Thr Val Arg Gln Ile Ile Ser Lys Leu Pro Leu
    770                 775                 780                 
Phe Ser Ser Cys Gln Ile Gln Gln Leu Met Lys Glu Pro Val Leu Gln
785                 790                 795                 800 
Asp Lys Arg Ser Asp His Val Lys Phe Cys Lys Tyr Ala Ala Glu Leu
                805                 810                 815     
Ile Glu Arg Val Ser Gly Lys Pro Leu Leu Ile Gly Thr Asp Val Ser
            820                 825                 830         
Leu Ala Arg Leu Gln Lys Ala Asp Val Val Ala Gln Ser Arg Ile Ser
        835                 840                 845             
Phe Pro Glu Lys Glu Leu Leu Leu Leu Ile Arg Asn His Leu Ile Ser
    850                 855                 860                 
Lys Gly Leu Gly Glu Thr Ala Thr Val Leu Thr Lys Glu Ala Asp Leu
865                 870                 875                 880 
Pro Met Thr Ala Ala Ser His Ser Ser Ala Phe Thr Pro Val Thr Ala
                885                 890                 895     
Ala Ala Ser Pro Val Ser Leu Pro Arg Thr Pro Arg Ile Ala Asn Gly
            900                 905                 910         
Ile Ala Thr Arg Leu Gly Ser His Ala Ala Val Gly Ala Ser Ala Pro
        915                 920                 925             
Ser Ala Pro Thr Ala His Pro Gln Pro Arg Pro Pro Gln Gly Pro Leu
    930                 935                 940                 
Ala Leu Pro Gly Pro Ser Tyr Ala Gly Asn Ser Pro Leu Ile Gly Arg
945                 950                 955                 960 
Ile Ser Phe Ile Arg Glu Arg Pro Ser Pro Cys Asn Gly Arg Lys Ile
                965                 970                 975     
Arg Val Leu Arg Gln Lys Ser Asp His Gly Ala Tyr Ser Gln Ser Pro
            980                 985                 990         
Ala Ile Lys Lys Gln Leu Asp Arg His Leu Pro Ser Pro Pro Thr Leu
        995                 1000                1005            
Asp Ser Ile Ile Thr Glu Tyr Leu Arg Glu Gln His Ala Arg Cys Lys
    1010                1015                1020                
Asn Pro Val Ala Thr Cys Pro Pro Phe Ser Leu Phe Thr Pro His Gln
1025                1030                1035                1040
Cys Pro Glu Pro Lys Gln Arg Arg Gln Ala Pro Ile Asn Phe Thr Ser
                1045                1050                1055    
Arg Leu Asn Arg Arg Ala Ser Phe Pro Lys Tyr Gly Gly Val Asp Gly
            1060                1065                1070        
Gly Cys Phe Asp Arg His Leu Ile Phe Ser Arg Phe Arg Pro Ile Ser
        1075                1080                1085            
Val Phe Arg Glu Ala Asn Glu Asp Glu Ser Gly Phe Thr Cys Cys Ala
    1090                1095                1100                
Phe Ser Ala Arg Glu Arg Phe Leu Met Leu Gly Thr Cys Thr Gly Gln
1105                1110                1115                1120
Leu Lys Leu Tyr Asn Val Phe Ser Gly Gln Glu Glu Ala Ser Tyr Asn
                1125                1130                1135    
Cys His Asn Ser Ala Ile Thr His Leu Glu Pro Ser Arg Asp Gly Ser
            1140                1145                1150        
Leu Leu Leu Thr Ser Ala Thr Trp Ser Gln Pro Leu Ser Ala Leu Trp
        1155                1160                1165            
Gly Met Lys Ser Val Phe Asp Met Lys His Ser Phe Thr Glu Asp His
    1170                1175                1180                
Tyr Val Glu Phe Ser Lys His Ser Gln Asp Arg Val Ile Gly Thr Lys
1185                1190                1195                1200
Gly Asp Ile Ala His Ile Tyr Asp Ile Gln Thr Gly Asn Lys Leu Leu
                1205                1210                1215    
Thr Leu Phe Asn Pro Asp Leu Ala Asn Asn Tyr Lys Arg Asn Cys Ala
            1220                1225                1230        
Thr Phe Asn Pro Thr Asp Asp Leu Val Leu Asn Asp Gly Val Leu Trp
        1235                1240                1245            
Asp Val Arg Ser Ala Gln Ala Ile His Lys Phe Asp Lys Phe Asn Met
    1250                1255                1260                
Asn Ile Ser Gly Val Phe His Pro Asn Gly Leu Glu Val Ile Ile Asn
1265                1270                1275                1280
Thr Glu Ile Trp Asp Leu Arg Thr Phe His Leu Leu His Thr Val Pro
                1285                1290                1295    
Ala Leu Asp Gln Cys Arg Val Val Phe Asn His Thr Gly Thr Val Met
            1300                1305                1310        
Tyr Gly Ala Met Leu Gln Ala Asp Asp Glu Asp Asp Leu Met Glu Glu
        1315                1320                1325            
Arg Met Lys Ser Pro Phe Gly Ser Ser Phe Arg Thr Phe Asn Ala Thr
    1330                1335                1340                
Asp Tyr Lys Pro Ile Ala Thr Ile Asp Val Lys Arg Asn Ile Phe Asp
1345                1350                1355                1360
Leu Cys Thr Asp Thr Lys Asp Cys Tyr Leu Ala Val Ile Glu Asn Gln
                1365                1370                1375    
Gly Ser Met Asp Ala Leu Asn Met Asp Thr Val Cys Arg Leu Tyr Glu
            1380                1385                1390        
Val Gly Arg Gln Arg Leu Ala Glu Asp Glu Asp Glu Glu Glu Asp Gln
        1395                1400                1405            
Glu Glu Glu Glu Gln Glu Glu Glu Asp Asp Asp Glu Asp Asp Asp Asp
    1410                1415                1420                
Thr Asp Asp Leu Asp Glu Leu Asp Thr Asp Gln Leu Leu Glu Ala Glu
1425                1430                1435                1440
Leu Glu Glu Asp Asp Asn Asn Glu Asn Ala Gly Glu Asp Gly Asp Asn
                1445                1450                1455    
Asp Phe Ser Pro Ser Asp Glu Glu Leu Ala Asn Leu Leu Glu Glu Gly
            1460                1465                1470        
Glu Asp Gly Glu Asp Glu Asp Ser Asp Ala Asp Glu Glu Val Glu Leu
        1475                1480                1485            
Ile Leu Gly Asp Thr Asp Ser Ser Asp Asn Ser Asp Leu Glu Asp Asp
    1490                1495                1500                
Ile Ile Leu Ser Leu Asn Glu
1505                1510    


<210> 6025
<211> 1387
<212> PRT
<213> Homo sapiens

<400> 6025
Pro Val Pro Cys Arg Val Ile Pro Ala Met Gly Lys Thr Ser Phe Arg
 1               5                  10                  15      
Ile Ile Phe Leu Pro Thr Glu Glu Gly Ser Ile Glu Ser Ser Leu Phe
            20                  25                  30          
Ile Asn Thr Ser Ser Tyr Gly Val Leu Ser Tyr His Val Ser Gly Ile
        35                  40                  45              
Gly Thr Arg Arg Ile Ser Thr Glu Gly Ser Ala Lys Gln Leu Pro Asn
    50                  55                  60                  
Ala Tyr Phe Leu Leu Pro Lys Val Gln Ser Ile Gln Leu Ser Gln Met
65                  70                  75                  80  
Gln Ala Glu Thr Thr Asn Thr Ser Leu Leu Gln Val Gln Leu Glu Cys
                85                  90                  95      
Ser Leu His Asn Lys Val Cys Gln Gln Leu Lys Gly Cys Tyr Leu Glu
            100                 105                 110         
Ser Asp Asp Val Leu Arg Leu Gln Met Ser Ile Met Val Thr Met Glu
        115                 120                 125             
Asn Phe Ser Lys Glu Phe Glu Glu Asn Thr Gln His Leu Leu Asp His
    130                 135                 140                 
Leu Ser Ile Val Tyr Val Ala Thr Asp Glu Ser Glu Thr Ser Asp Asp
145                 150                 155                 160 
Ser Ala Val Asn Met Tyr Ile Leu His Ser Gly Asn Ser Leu Ile Trp
                165                 170                 175     
Ile Gln Asp Ile Arg His Phe Ser Gln Arg Asp Ala Leu Ser Leu Gln
            180                 185                 190         
Phe Glu Pro Val Leu Leu Pro Thr Ser Thr Thr Asn Phe Thr Lys Ile
        195                 200                 205             
Ala Ser Phe Thr Cys Lys Ala Ala Thr Ser Cys Asp Ser Gly Ile Ile
    210                 215                 220                 
Glu Asp Val Lys Lys Thr Thr His Thr Pro Thr Leu Lys Ala Cys Leu
225                 230                 235                 240 
Phe Ser Ser Val Ala Gln Gly Tyr Phe Arg Met Asp Ser Ser Ala Thr
                245                 250                 255     
Gln Phe His Ile Glu Thr His Glu Asn Thr Ser Gly Leu Trp Ser Ile
            260                 265                 270         
Trp Tyr Arg Asn His Phe Asp Arg Ser Val Val Leu Asn Asp Val Phe
        275                 280                 285             
Leu Ser Lys Glu Thr Lys His Met Leu Lys Ile Leu Asn Phe Thr Gly
    290                 295                 300                 
Pro Leu Phe Leu Pro Pro Gly Cys Trp Asn Ile Phe Ser Leu Lys Leu
305                 310                 315                 320 
Ala Val Lys Asp Ile Ala Ile Asn Leu Phe Thr Asn Val Phe Leu Thr
                325                 330                 335     
Thr Asn Ile Gly Ala Ile Phe Ala Ile Pro Leu Gln Ile Tyr Ser Ala
            340                 345                 350         
Pro Thr Lys Glu Gly Ser Leu Gly Phe Glu Val Ile Ala His Cys Gly
        355                 360                 365             
Met His Tyr Phe Met Gly Lys Ser Lys Ala Gly Asn Pro Asn Trp Asn
    370                 375                 380                 
Gly Ser Leu Ser Leu Asp Gln Ser Thr Trp Asn Val Asp Ser Glu Leu
385                 390                 395                 400 
Ala Asn Lys Leu Tyr Glu Arg Trp Lys Lys Tyr Lys Asn Gly Asp Val
                405                 410                 415     
Cys Lys Phe Gly Thr Asp Thr Gln Met Ile Asn Phe Thr Thr Gly Glu
            420                 425                 430         
Phe Gln Leu Thr Glu Ala Cys Pro Tyr Leu Gly Thr His Ser Glu Glu
        435                 440                 445             
Ser Arg Phe Gly Ile Leu His Leu His Leu Gln Pro Leu Glu Met Lys
    450                 455                 460                 
Arg Val Gly Val Val Phe Thr Pro Ala Asp Tyr Gly Lys Val Thr Ser
465                 470                 475                 480 
Leu Ile Leu Ile Arg Asn Asn Leu Thr Val Ile Asp Met Ile Gly Val
                485                 490                 495     
Glu Gly Phe Gly Ala Arg Glu Leu Leu Lys Val Gly Gly Arg Leu Pro
            500                 505                 510         
Gly Ala Gly Gly Ser Leu Arg Phe Lys Val Pro Glu Ser Thr Leu Met
        515                 520                 525             
Asp Cys Arg Arg Gln Leu Lys Asp Ser Lys Gln Ile Leu Ser Ile Thr
    530                 535                 540                 
Lys Asn Phe Lys Val Glu Asn Ile Gly Pro Leu Pro Ile Thr Val Ser
545                 550                 555                 560 
Ser Leu Lys Ile Asn Gly Tyr Asn Cys Gln Gly Tyr Gly Phe Glu Val
                565                 570                 575     
Leu Asp Cys His Gln Phe Ser Leu Asp Pro Asn Thr Ser Arg Asp Ile
            580                 585                 590         
Ser Ile Val Phe Thr Pro Asp Phe Thr Ser Ser Trp Val Ile Arg Asp
        595                 600                 605             
Leu Ser Leu Val Thr Ala Ala Asp Leu Glu Phe Arg Phe Thr Leu Asn
    610                 615                 620                 
Val Thr Leu Pro His His Leu Leu Pro Leu Cys Ala Asp Val Val Pro
625                 630                 635                 640 
Gly Pro Ser Trp Glu Glu Ser Phe Trp Arg Leu Thr Val Phe Phe Val
                645                 650                 655     
Ser Leu Ser Leu Leu Gly Val Ile Leu Ile Ala Phe Gln Gln Ala Gln
            660                 665                 670         
Tyr Ile Leu Met Glu Phe Met Lys Thr Arg Gln Arg Gln Asn Ala Ser
        675                 680                 685             
Ser Ser Ser Gln Gln Asn Asn Gly Pro Met Asp Val Ile Ser Pro His
    690                 695                 700                 
Ser Tyr Lys Ser Asn Cys Lys Asn Phe Leu Asp Thr Tyr Gly Pro Ser
705                 710                 715                 720 
Asp Lys Gly Arg Gly Lys Asn Cys Leu Pro Val Asn Thr Pro Gln Ser
                725                 730                 735     
Arg Ile Gln Asn Ala Ala Lys Arg Ser Pro Ala Thr Tyr Gly His Ser
            740                 745                 750         
Gln Lys Lys His Lys Cys Ser Val Tyr Tyr Ser Lys His Lys Thr Ser
        755                 760                 765             
Thr Ala Ala Ala Ser Ser Thr Ser Thr Thr Thr Glu Glu Lys Gln Thr
    770                 775                 780                 
Ser Pro Leu Gly Ser Ser Leu Pro Ala Ala Lys Glu Asp Ile Cys Thr
785                 790                 795                 800 
Asp Ala Met Arg Glu Asn Trp Ile Ser Leu Arg Tyr Ala Ser Gly Ile
                805                 810                 815     
Asn Val Asn Leu Gln Lys Asn Leu Thr Leu Pro Lys Asn Leu Leu Asn
            820                 825                 830         
Lys Glu Glu Asn Thr Leu Lys Asn Thr Ile Val Phe Ser Asn Pro Ser
        835                 840                 845             
Ser Glu Cys Ser Met Lys Glu Gly Ile Gln Thr Cys Met Phe Pro Lys
    850                 855                 860                 
Glu Thr Asp Ile Lys Thr Ser Glu Asn Thr Ala Glu Phe Lys Glu Arg
865                 870                 875                 880 
Glu Leu Cys Pro Leu Lys Thr Ser Lys Lys Leu Pro Glu Asn His Leu
                885                 890                 895     
Pro Arg Asn Ser Pro Gln Tyr His Gln Pro Asp Leu Pro Glu Ile Ser
            900                 905                 910         
Arg Lys Asn Asn Gly Asn Asn Gln Gln Val Pro Val Lys Asn Glu Val
        915                 920                 925             
Asp His Cys Glu Asn Leu Lys Lys Val Asp Thr Lys Pro Ser Ser Glu
    930                 935                 940                 
Lys Lys Ile His Lys Thr Ser Arg Glu Asp Met Phe Ser Glu Lys Gln
945                 950                 955                 960 
Asp Ile Pro Phe Val Glu Gln Glu Asp Pro Tyr Arg Lys Lys Lys Leu
                965                 970                 975     
Gln Glu Lys Arg Glu Gly Asn Leu Gln Asn Leu Asn Trp Ser Lys Ser
            980                 985                 990         
Arg Thr Cys Arg Lys Asn Lys Lys Arg Gly Val Ala Pro Val Ser Arg
        995                 1000                1005            
Pro Pro Glu Gln Ser Asp Leu Lys Leu Val Cys Ser Asp Phe Glu Arg
    1010                1015                1020                
Ser Glu Leu Ser Ser Asp Ile Asn Val Arg Ser Trp Cys Ile Gln Glu
1025                1030                1035                1040
Ser Thr Arg Glu Val Cys Lys Ala Asp Ala Glu Ile Ala Ser Ser Leu
                1045                1050                1055    
Pro Ala Ala Gln Arg Glu Ala Glu Gly Tyr Tyr Gln Lys Pro Glu Lys
            1060                1065                1070        
Lys Cys Val Asp Lys Phe Cys Ser Asp Ser Ser Ser Asp Cys Gly Ser
        1075                1080                1085            
Ser Ser Gly Ser Val Arg Ala Ser Arg Gly Ser Trp Gly Ser Trp Ser
    1090                1095                1100                
Ser Thr Ser Ser Ser Asp Gly Asp Lys Lys Pro Met Val Asp Ala Gln
1105                1110                1115                1120
His Phe Leu Pro Ala Gly Asp Ser Val Ser Gln Asn Asp Phe Pro Ser
                1125                1130                1135    
Glu Ala Pro Ile Ser Leu Asn Leu Ser His Asn Ile Cys Asn Pro Met
            1140                1145                1150        
Thr Val Asn Ser Leu Pro Gln Tyr Ala Glu Pro Ser Cys Pro Ser Leu
        1155                1160                1165            
Pro Ala Gly Pro Thr Gly Val Glu Glu Asp Lys Gly Leu Tyr Ser Pro
    1170                1175                1180                
Gly Asp Leu Trp Pro Thr Pro Pro Val Cys Val Thr Ser Ser Leu Asn
1185                1190                1195                1200
Cys Thr Leu Glu Asn Gly Val Pro Cys Val Ile Gln Glu Ser Ala Pro
                1205                1210                1215    
Val His Asn Ser Phe Ile Asp Trp Ser Ala Thr Cys Glu Gly Gln Phe
            1220                1225                1230        
Ser Ser Ala Tyr Cys Pro Leu Glu Leu Asn Asp Tyr Asn Ala Phe Pro
        1235                1240                1245            
Glu Glu Asn Met Asn Tyr Ala Asn Gly Phe Pro Cys Pro Ala Asp Val
    1250                1255                1260                
Gln Thr Asp Phe Ile Asp His Asn Ser Gln Ser Thr Trp Asn Thr Pro
1265                1270                1275                1280
Pro Asn Met Pro Ala Ala Trp Gly His Ala Ser Phe Ile Ser Ser Pro
                1285                1290                1295    
Pro Tyr Leu Thr Ser Thr Arg Ser Leu Ser Pro Met Ser Gly Leu Phe
            1300                1305                1310        
Gly Ser Ile Trp Ala Pro Gln Ser Asp Val Tyr Glu Asn Cys Cys Pro
        1315                1320                1325            
Ile Asn Pro Thr Thr Glu His Ser Thr His Met Glu Asn Gln Ala Val
    1330                1335                1340                
Val Cys Lys Glu Tyr Tyr Pro Gly Phe Asn Pro Phe Arg Ala Tyr Met
1345                1350                1355                1360
Asn Leu Asp Ile Trp Thr Thr Thr Ala Asn Arg Asn Ala Asn Phe Pro
                1365                1370                1375    
Leu Ser Arg Asp Ser Ser Tyr Cys Gly Asn Val
            1380                1385        


<210> 6026
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 6026
Met Gly Lys Thr Ser Phe Arg Ile Ile Phe Leu Pro Thr Glu Glu Gly
 1               5                  10                  15      
Ser Ile Glu Ser Ser Leu Phe Ile Asn Thr Ser Ser Tyr Gly Val Leu
            20                  25                  30          
Ser Tyr His Val Ser Gly Ile Gly Thr Arg Arg Ile Ser Thr Glu Gly
        35                  40                  45              
Ser Ala Lys Gln Leu Pro Asn Ala Tyr Phe Leu Leu Pro Lys Val Gln
    50                  55                  60                  
Ser Ile Gln Leu Ser Gln Met Gln Ala Glu Thr Thr Asn Thr Ser Leu
65                  70                  75                  80  
Leu Gln Val Gln Leu Glu Cys Ser Leu His Asn Lys Val Cys Gln Gln
                85                  90                  95      
Leu Lys Gly Cys Tyr Leu Glu Ser Asp Asp Val Leu Arg Leu Gln Met
            100                 105                 110         
Ser Ile Met Val Thr Met Glu Asn Phe Ser Lys Glu Phe Glu Glu Asn
        115                 120                 125             
Thr Gln His Leu Leu Asp His Leu Ser Ile Val Tyr Val Ala Thr Asp
    130                 135                 140                 
Glu Ser Glu Thr Ser Asp Asp Ser Ala Val Asn Met Tyr Ile Leu His
145                 150                 155                 160 
Ser Gly Asn Ser Leu Ile Trp Ile Gln Asp Ile Arg His Phe Ser Gln
                165                 170                 175     
Arg Asp Ala Leu Ser Leu Gln Phe Glu Pro Val Leu Leu Pro Thr Ser
            180                 185                 190         
Thr Thr Asn Phe Thr Lys Ile Ala Ser Phe Thr Cys Lys Ala Ala Thr
        195                 200                 205             
Ser Cys Asp Ser Gly Ile Ile Glu Asp Val Lys Lys Thr Thr His Thr
    210                 215                 220                 
Pro Thr Leu Lys Ala Cys Leu Phe Ser Ser Val Ala Gln Gly Tyr Phe
225                 230                 235                 240 
Arg Met Asp Ser Ser Ala Thr Gln Phe His Ile Glu Thr His Glu Asn
                245                 250                 255     
Thr Ser Gly Leu Trp Ser Ile Trp Tyr Arg Asn His Phe Asp Arg Ser
            260                 265                 270         
Val Val Leu Asn Asp Val Phe Leu Ser Lys Glu Thr Lys His Met Leu
        275                 280                 285             
Lys Ile Leu Asn Phe Thr Gly Pro Leu Phe Leu Pro Pro Gly Cys Trp
    290                 295                 300                 
Asn Ile Phe Ser Leu Lys Leu Ala Val Lys Asp Ile Ala Ile Asn Leu
305                 310                 315                 320 
Phe Thr Asn Val Phe Leu Thr Thr Asn Ile Gly Ala Ile Phe Ala Ile
                325                 330                 335     
Pro Leu Gln Ile Tyr Ser Ala Pro Thr Lys Glu Gly Ser Leu Gly Phe
            340                 345                 350         
Glu Val Ile Ala His Cys Gly Met His Tyr Phe Met Gly Lys Ser Lys
        355                 360                 365             
Ala Gly Asn Pro Asn Trp Asn Gly Ser Leu Ser Leu Asp Gln Ser Thr
    370                 375                 380                 
Trp Asn Val Asp Ser Glu Leu Ala Asn Lys Leu Tyr Glu Arg Trp Lys
385                 390                 395                 400 
Lys Tyr Lys Asn Gly Asp Val Cys Lys Arg Asn Val Leu Gly Thr Thr
                405                 410                 415     
Arg Phe Ala His Leu Lys Lys Ser Lys Glu Ser Glu Ser Phe Val Phe
            420                 425                 430         
Phe Leu Pro Arg Leu Ile Ala Glu Pro Gly Leu Met Leu Asn Phe Ser
        435                 440                 445             
Ala Thr Ala Leu Arg Ser Arg Met Ile Lys Tyr Phe Val Val Gln Asn
    450                 455                 460                 
Pro Ser Ser Trp Pro Val Ser Leu Gln Leu Leu Pro Leu Ser Leu Tyr
465                 470                 475                 480 
Pro Lys Pro Glu Ala Leu Val His Leu Leu His Arg Trp Phe Gly Thr
                485                 490                 495     
Asp Met Gln Met Ile Asn Phe Thr Thr Gly Glu Phe Gln Leu Thr Glu
            500                 505                 510         
Ala Cys Pro Tyr Leu Gly Thr His Ser Glu Glu Ser Arg Phe Gly Ile
        515                 520                 525             
Leu His Leu His Leu Gln Pro Leu Glu Met Lys Arg Val Gly Val Val
    530                 535                 540                 
Phe Thr Pro Ala Asp Tyr Gly Lys Val Thr Ser Leu Ile Leu Ile Arg
545                 550                 555                 560 
Asn Asn Leu Thr Val Ile Asp Met Ile Gly Val Glu Gly Phe Gly Ala
                565                 570                 575     
Arg Glu Leu Leu Lys Val Gly Gly Arg Leu Pro Gly Ala Gly Gly Ser
            580                 585                 590         
Leu Arg Phe Lys Val Pro Glu Ser Thr Leu Met Asp Cys Arg Arg Gln
        595                 600                 605             
Leu Lys Asp Ser Lys Gln Ile Leu Ser Ile Thr Lys Asn Phe Lys Val
    610                 615                 620                 
Glu Asn Ile Gly Pro Leu Pro Ile Thr Val Ser Ser Leu Lys Ile Asn
625                 630                 635                 640 
Gly Tyr Asn Cys Gln Gly Tyr Gly Phe Glu Val Leu Asp Cys His Gln
                645                 650                 655     
Phe Ser Leu Asp Pro Asn Thr Ser Arg Asp Ile Ser Ile Val Phe Thr
            660                 665                 670         
Pro Asp Phe Thr Ser Ser Trp Val Ile Arg Asp Leu Ser Leu Val Thr
        675                 680                 685             
Ala Ala Asp Leu Glu Phe Arg Phe Thr Leu Asn Val Thr Leu Pro His
    690                 695                 700                 
His Leu Leu Pro Leu Cys Ala Asp Val Val Pro Gly Pro Ser Trp Glu
705                 710                 715                 720 
Glu Ser Phe Trp Arg Leu Thr Val Phe Phe Val Ser Leu Ser Leu Leu
                725                 730                 735     
Gly Val Ile Leu Ile Ala Phe Gln Gln Ala Gln Tyr Ile Leu Met Glu
            740                 745                 750         
Phe Met Lys Thr Arg Gln Arg Gln Asn Ala Ser Ser Ser Ser Gln Gln
        755                 760                 765             
Asn Asn Gly Pro Met Asp Val Ile Ser Pro His Ser Tyr Lys Ser Asn
    770                 775                 780                 
Cys Lys Asn Phe Leu Asp Thr Tyr Gly Pro Ser Asp Lys Gly Arg Gly
785                 790                 795                 800 
Lys Asn Cys Leu Pro Val Asn Thr Pro Gln Ser Arg Ile Gln Asn Ala
                805                 810                 815     
Ala Lys Arg Ser Pro Ala Thr Tyr Gly His Ser Gln Lys Lys His Lys
            820                 825                 830         
Cys Ser Val Tyr Tyr Ser Lys His Lys Thr Ser Thr Ala Ala Ala Ser
        835                 840                 845             
Ser Thr Ser Thr Thr Thr Glu Glu Lys Gln Thr Ser Pro Leu Gly Ser
    850                 855                 860                 
Ser Leu Pro Ala Ala Lys Glu Asp Ile Cys Thr Asp Ala Met Arg Glu
865                 870                 875                 880 
Asn Trp Ile Ser Leu Arg Tyr Ala Ser Gly Ile Asn Val Asn Leu Gln
                885                 890                 895     
Lys Asn Leu Thr Leu Pro Lys Asn Leu Leu Asn Lys Glu Glu Asn Thr
            900                 905                 910         
Leu Lys Asn Thr Ile Val Phe Ser Asn Pro Ser Ser Glu Cys Ser Met
        915                 920                 925             
Lys Glu Gly Ile Gln Thr Cys Met Phe Pro Lys Glu Thr Asp Ile Lys
    930                 935                 940                 
Thr Ser Glu Asn Thr Ala Glu Phe Lys Glu Arg Glu Leu Cys Pro Leu
945                 950                 955                 960 
Lys Thr Ser Lys Lys Leu Pro Glu Asn His Leu Pro Arg Asn Ser Pro
                965                 970                 975     
Gln Tyr His Gln Pro Asp Leu Pro Glu Ile Ser Arg Lys Asn Asn Gly
            980                 985                 990         
Asn Asn Gln Gln Val Pro Val Lys Asn Glu Val Asp His Cys Glu Asn
        995                 1000                1005            
Leu Lys Lys Val Asp Thr Lys Pro Ser Ser Glu Lys Lys Ile His Lys
    1010                1015                1020                
Thr Ser Arg Glu Asp Met Phe Ser Glu Lys Gln Asp Ile Pro Phe Val
1025                1030                1035                1040
Glu Gln Glu Asp Pro Tyr Arg Lys Lys Lys Leu Gln Glu Lys Arg Glu
                1045                1050                1055    
Gly Asn Leu Gln Asn Leu Asn Trp Ser Lys Ser Arg Thr Cys Arg Lys
            1060                1065                1070        
Asn Lys Lys Arg Gly Val Ala Pro Val Ser Arg Pro Pro Glu Gln Ser
        1075                1080                1085            
Asp Leu Lys Leu Val Cys Ser Asp Phe Glu Arg Ser Glu Leu Ser Ser
    1090                1095                1100                
Asp Ile Asn Val Arg Ser Trp Cys Ile Gln Glu Ser Thr Arg Glu Val
1105                1110                1115                1120
Cys Lys Ala Asp Ala Glu Ile Ala Ser Ser Leu Pro Ala Ala Gln Arg
                1125                1130                1135    
Glu Ala Glu Gly Tyr Tyr Gln Lys Pro Glu Lys Lys Cys Val Asp Lys
            1140                1145                1150        
Phe Cys Ser Asp Ser Ser Ser Asp Cys Gly Ser Ser Ser Gly Ser Val
        1155                1160                1165            
Arg Ala Ser Arg Gly Ser Trp Gly Ser Trp Ser Ser Thr Ser Ser Ser
    1170                1175                1180                
Asp Gly Asp Lys Lys Pro Met Val Asp Ala Gln His Phe Leu Pro Ala
1185                1190                1195                1200
Gly Asp Ser Val Ser Gln Asn Asp Phe Pro Ser Glu Ala Pro Ile Ser
                1205                1210                1215    
Leu Asn Leu Ser His Asn Ile Cys Asn Pro Met Thr Val Asn Ser Leu
            1220                1225                1230        
Pro Gln Tyr Ala Glu Pro Ser Cys Pro Ser Leu Pro Ala Gly Pro Thr
        1235                1240                1245            
Gly Val Glu Glu Asp Lys Gly Leu Tyr Ser Pro Gly Asp Leu Trp Pro
    1250                1255                1260                
Thr Pro Pro Val Cys Val Thr Ser Ser Leu Asn Cys Thr Leu Glu Asn
1265                1270                1275                1280
Gly Val Pro Cys Val Ile Gln Glu Ser Ala Pro Val His Asn Ser Phe
                1285                1290                1295    
Ile Asp Trp Ser Ala Thr Cys Glu Gly Gln Phe Ser Ser Ala Tyr Cys
            1300                1305                1310        
Pro Leu Glu Leu Asn Asp Tyr Asn Ala Phe Pro Glu Glu Asn Met Asn
        1315                1320                1325            
Tyr Ala Asn Gly Phe Pro Cys Pro Ala Asp Val Gln Thr Asp Phe Ile
    1330                1335                1340                
Asp His Asn Ser Gln Ser Thr Trp Asn Thr Pro Pro Asn Met Pro Ala
1345                1350                1355                1360
Ala Trp Gly His Ala Ser Phe Ile Ser Ser Pro Pro Tyr Leu Thr Ser
                1365                1370                1375    
Thr Arg Ser Leu Ser Pro Met Ser Gly Leu Phe Gly Ser Ile Trp Ala
            1380                1385                1390        
Pro Gln Ser Asp Val Tyr Glu Asn Cys Cys Pro Ile Asn Pro Thr Thr
        1395                1400                1405            
Glu His Ser Thr His Met Glu Asn Gln Ala Val Val Cys Lys Glu Tyr
    1410                1415                1420                
Tyr Pro Gly Phe Asn Pro Phe Arg Ala Tyr Met Asn Leu Asp Ile Trp
1425                1430                1435                1440
Thr Thr Thr Ala Asn Arg Asn Ala Asn Phe Pro Leu Ser Arg Asp Ser
                1445                1450                1455    
Ser Tyr Cys Gly Asn Val
            1460        


<210> 6027
<211> 427
<212> PRT
<213> Homo sapiens

<400> 6027
Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn
 1               5                  10                  15      
Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr
            20                  25                  30          
Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln
        35                  40                  45              
Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn
    50                  55                  60                  
Ser Gln Ser Gly Phe Arg Cys Ala Asn Cys Ala Glu Asn Glu Glu Gly
65                  70                  75                  80  
Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp Gly Glu Ile Leu
                85                  90                  95      
Val Glu Leu Val Gln Tyr Cys His Thr Gln Met Asp Val Thr Asp Tyr
            100                 105                 110         
Lys Gly Glu Thr Val Phe His Tyr Ala Val Gln Gly Asp Asn Ser Gln
        115                 120                 125             
Val Leu Gln Leu Leu Gly Arg Asn Ala Val Ala Gly Leu Asn Gln Val
    130                 135                 140                 
Asn Asn Gln Gly Leu Thr Pro Leu His Leu Ala Cys Gln Leu Gly Lys
145                 150                 155                 160 
Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala Arg Cys Asn Ile
                165                 170                 175     
Met Gly Pro Asn Gly Tyr Pro Ile His Ser Ala Met Lys Phe Ser Gln
            180                 185                 190         
Lys Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser Ser Gln Ile His
        195                 200                 205             
Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His Trp Ala Lys Asn
    210                 215                 220                 
Ala Glu Met Ala Arg Met Leu Leu Lys Arg Gly Cys Asn Val Asn Ser
225                 230                 235                 240 
Thr Ser Ser Ala Gly Asn Thr Ala Leu His Val Ala Val Met Arg Asn
                245                 250                 255     
Arg Phe Asp Cys Ala Ile Val Leu Leu Thr His Gly Ala Asn Ala Asp
            260                 265                 270         
Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu Ala Met Ser Lys
        275                 280                 285             
Asp Asn Val Glu Met Ile Lys Ala Leu Ile Val Phe Gly Ala Glu Val
    290                 295                 300                 
Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Thr Phe Leu Ala Ser Lys
305                 310                 315                 320 
Ile Gly Arg Leu Val Thr Arg Lys Ala Ile Leu Thr Leu Leu Arg Thr
                325                 330                 335     
Val Gly Ala Glu Tyr Cys Phe Pro Pro Ile His Gly Val Pro Ala Glu
            340                 345                 350         
Gln Gly Ser Ala Ala Pro His His Pro Phe Ser Leu Glu Arg Ala Gln
        355                 360                 365             
Pro Pro Pro Ile Ser Leu Asn Asn Leu Gly Ser His Pro Ser Gln Ala
    370                 375                 380                 
Gly Trp Trp Ala Trp Gly Ala Val Ser Asp Gly Thr Thr Gly Ser His
385                 390                 395                 400 
Ala His Leu Thr Gly Pro Glu Ala Ser Val His Pro Gly Leu His Glu
                405                 410                 415     
Gly Arg Glu Ala Asp Met Gln Asn Leu Ser Pro
            420                 425         


<210> 6028
<211> 752
<212> PRT
<213> Homo sapiens

<400> 6028
Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn
 1               5                  10                  15      
Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr
            20                  25                  30          
Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln
        35                  40                  45              
Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn
    50                  55                  60                  
Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala
65                  70                  75                  80  
Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu
                85                  90                  95      
Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp
            100                 105                 110         
Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu
        115                 120                 125             
Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala
    130                 135                 140                 
Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys
145                 150                 155                 160 
Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His
                165                 170                 175     
Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr
            180                 185                 190         
Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn
        195                 200                 205             
Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu
    210                 215                 220                 
His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu
225                 230                 235                 240 
Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile
                245                 250                 255     
His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile
            260                 265                 270         
Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala
        275                 280                 285             
Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu
    290                 295                 300                 
Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala
305                 310                 315                 320 
Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu
                325                 330                 335     
Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr
            340                 345                 350         
Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala
        355                 360                 365             
Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu
    370                 375                 380                 
Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Gln Leu Gln Asp Leu
385                 390                 395                 400 
Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser Met
                405                 410                 415     
Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly Gly
            420                 425                 430         
Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys
        435                 440                 445             
Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr
    450                 455                 460                 
Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met
465                 470                 475                 480 
Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg
                485                 490                 495     
Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg
            500                 505                 510         
Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val
        515                 520                 525             
Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu
    530                 535                 540                 
Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn
545                 550                 555                 560 
Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val
                565                 570                 575     
Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro
            580                 585                 590         
Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu
        595                 600                 605             
Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys
    610                 615                 620                 
Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly
625                 630                 635                 640 
Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe Arg
                645                 650                 655     
Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu
            660                 665                 670         
Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala
        675                 680                 685             
Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe
    690                 695                 700                 
Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser
705                 710                 715                 720 
Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr
                725                 730                 735     
Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser Pro
            740                 745                 750         


<210> 6029
<211> 806
<212> PRT
<213> Homo sapiens

<400> 6029
Met Gln Phe Phe Gly Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn
 1               5                  10                  15      
Leu Phe Ser Asn Pro Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr
            20                  25                  30          
Thr Ser Ser Asp Arg Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln
        35                  40                  45              
Asn Thr Pro Asn Arg Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn
    50                  55                  60                  
Ser Gln Ser Gly Phe Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala
65                  70                  75                  80  
Leu Val Asn Phe His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu
                85                  90                  95      
Ser Ser Pro Gln Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp
            100                 105                 110         
Leu Ile Arg Asn His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu
        115                 120                 125             
Leu Gly Ile Arg Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala
    130                 135                 140                 
Asn Cys Ala Glu Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys
145                 150                 155                 160 
Arg Lys Gly Asp Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His
                165                 170                 175     
Thr Gln Met Asp Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr
            180                 185                 190         
Ala Val Gln Gly Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn
        195                 200                 205             
Ala Val Ala Gly Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu
    210                 215                 220                 
His Leu Ala Cys Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu
225                 230                 235                 240 
Leu Cys Asn Ala Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile
                245                 250                 255     
His Ser Ala Met Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile
            260                 265                 270         
Ser Met Asp Ser Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala
        275                 280                 285             
Ser Pro Leu His Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu
    290                 295                 300                 
Lys Arg Gly Cys Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala
305                 310                 315                 320 
Leu His Val Ala Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu
                325                 330                 335     
Leu Thr His Gly Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr
            340                 345                 350         
Pro Leu His Leu Ala Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala
        355                 360                 365             
Leu Ile Val Phe Gly Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu
    370                 375                 380                 
Thr Pro Thr Phe Leu Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys
385                 390                 395                 400 
Ala Ile Leu Thr Leu Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro
                405                 410                 415     
Pro Ile His Gly Val Pro Ala Glu Gln Gly Ser Ala Ala Pro His His
            420                 425                 430         
Pro Phe Ser Leu Glu Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn
        435                 440                 445             
Leu Glu Leu Gln Asp Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala
    450                 455                 460                 
Phe Ile Leu Gly Ser Met Arg Asp Glu Lys Arg Thr His Asp His Leu
465                 470                 475                 480 
Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu
                485                 490                 495     
Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe
            500                 505                 510         
Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile
        515                 520                 525             
Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met
    530                 535                 540                 
Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu
545                 550                 555                 560 
Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp
                565                 570                 575     
Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln
            580                 585                 590         
Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val
        595                 600                 605             
Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln
    610                 615                 620                 
Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala
625                 630                 635                 640 
Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu
                645                 650                 655     
Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn
            660                 665                 670         
Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser
        675                 680                 685             
Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr
    690                 695                 700                 
Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr
705                 710                 715                 720 
Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr
                725                 730                 735     
Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met
            740                 745                 750         
Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile
        755                 760                 765             
Met Leu Asp Glu Val Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu
    770                 775                 780                 
Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile
785                 790                 795                 800 
Gln Leu Leu Leu Ser Pro
                805     


<210> 6030
<211> 616
<212> PRT
<213> Homo sapiens

<400> 6030
Tyr Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala Leu Val Asn Phe
 1               5                  10                  15      
His Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu Ser Ser Pro Gln
            20                  25                  30          
Val Leu His Thr Glu Val Leu Gln His Leu Thr Asp Leu Ile Arg Asn
        35                  40                  45              
His Pro Ser Trp Ser Val Ala His Leu Ala Val Glu Leu Gly Ile Arg
    50                  55                  60                  
Glu Cys Phe His His Ser Arg Ile Ile Ser Cys Ala Asn Cys Ala Glu
65                  70                  75                  80  
Asn Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp
                85                  90                  95      
Gly Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Thr Gln Met Asp
            100                 105                 110         
Val Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr Ala Val Gln Gly
        115                 120                 125             
Asp Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn Ala Val Ala Gly
    130                 135                 140                 
Leu Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His Leu Ala Cys
145                 150                 155                 160 
Gln Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala
                165                 170                 175     
Arg Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile His Ser Ala Met
            180                 185                 190         
Lys Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser
        195                 200                 205             
Ser Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His
    210                 215                 220                 
Trp Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg Gly Cys
225                 230                 235                 240 
Asn Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala Leu His Val Ala
                245                 250                 255     
Val Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu Leu Thr His Gly
            260                 265                 270         
Ala Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu
        275                 280                 285             
Ala Met Ser His Leu Leu Cys Leu Asp Gly Gly Gly Val Lys Gly Leu
    290                 295                 300                 
Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu Lys Ala Ser Gly Val Ala
305                 310                 315                 320 
Thr Lys Asp Leu Phe Asp Trp Val Ala Gly Thr Ser Thr Gly Gly Ile
                325                 330                 335     
Leu Ala Leu Ala Ile Leu His Ser Lys Ser Met Ala Tyr Met Arg Gly
            340                 345                 350         
Met Tyr Phe Arg Met Lys Asp Glu Val Phe Arg Gly Ser Arg Pro Tyr
        355                 360                 365             
Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys Arg Glu Phe Gly Glu His
    370                 375                 380                 
Thr Lys Met Thr Asp Val Arg Lys Pro Lys Val Met Leu Thr Gly Thr
385                 390                 395                 400 
Leu Ser Asp Arg Gln Pro Ala Glu Leu His Leu Phe Arg Asn Tyr Asp
                405                 410                 415     
Ala Pro Glu Thr Val Arg Glu Pro Arg Phe Asn Gln Asn Val Asn Leu
            420                 425                 430         
Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu Val Trp Arg Ala Ala Arg
        435                 440                 445             
Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg Pro Asn Gly Arg Phe Leu
    450                 455                 460                 
Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr Leu Asp Ala Met Thr Glu
465                 470                 475                 480 
Ile His Glu Tyr Asn Gln Asp Leu Ile Arg Lys Gly Gln Ala Asn Lys
                485                 490                 495     
Val Lys Lys Leu Ser Ile Val Val Ser Leu Gly Thr Gly Arg Ser Pro
            500                 505                 510         
Gln Val Pro Val Thr Cys Val Asp Val Phe Arg Pro Ser Asn Pro Trp
        515                 520                 525             
Glu Leu Ala Lys Thr Val Phe Gly Ala Lys Glu Leu Gly Lys Met Val
    530                 535                 540                 
Val Asp Cys Cys Thr Asp Pro Asp Gly Arg Ala Val Asp Arg Ala Arg
545                 550                 555                 560 
Ala Trp Cys Glu Met Val Gly Ile Gln Tyr Phe Arg Leu Asn Pro Gln
                565                 570                 575     
Leu Gly Thr Asp Ile Met Leu Asp Glu Val Ser Asp Thr Val Leu Val
            580                 585                 590         
Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile Tyr Glu His Arg Glu Glu
        595                 600                 605             
Phe Gln Lys Leu Ile Gln Leu Leu
    610                 615     


<210> 6031
<211> 849
<212> PRT
<213> Homo sapiens

<400> 6031
Arg Ser Pro Thr Ser Ser Ala Leu Arg Thr Pro Lys Ser Pro Pro Asp
 1               5                  10                  15      
Pro Pro Leu Asp Ile Pro Arg Val Ser Asp Ser Glu Thr Glu Gly Glu
            20                  25                  30          
Asp Gly Gly Ala Ser Pro Pro Ala Pro Gln Lys Met Gln Phe Phe Gly
        35                  40                  45              
Arg Leu Val Asn Thr Phe Ser Gly Val Thr Asn Leu Phe Ser Asn Pro
    50                  55                  60                  
Phe Arg Val Lys Glu Val Ala Val Ala Asp Tyr Thr Ser Ser Asp Arg
65                  70                  75                  80  
Val Arg Glu Glu Gly Gln Leu Ile Leu Phe Gln Asn Thr Pro Asn Arg
                85                  90                  95      
Thr Trp Asp Cys Val Leu Val Asn Pro Arg Asn Ser Gln Ser Gly Phe
            100                 105                 110         
Arg Leu Phe Gln Leu Glu Leu Glu Ala Asp Ala Leu Val Asn Phe His
        115                 120                 125             
Gln Tyr Ser Ser Gln Leu Leu Pro Phe Tyr Glu Ser Ser Pro Gln Val
    130                 135                 140                 
Leu His Thr Glu Val Leu Gln His Leu Thr Asp Leu Ile Arg Asn His
145                 150                 155                 160 
Pro Ser Trp Ser Val Ala His Leu Ala Val Glu Leu Gly Ile Arg Glu
                165                 170                 175     
Cys Phe His His Ser Arg Ile Ile Ser Cys Ala Asn Cys Ala Glu Asn
            180                 185                 190         
Glu Glu Gly Cys Thr Pro Leu His Leu Ala Cys Arg Lys Gly Asp Gly
        195                 200                 205             
Glu Ile Leu Val Glu Leu Val Gln Tyr Cys His Thr Gln Met Asp Val
    210                 215                 220                 
Thr Asp Tyr Lys Gly Glu Thr Val Phe His Tyr Ala Val Gln Gly Asp
225                 230                 235                 240 
Asn Ser Gln Val Leu Gln Leu Leu Gly Arg Asn Ala Val Ala Gly Leu
                245                 250                 255     
Asn Gln Val Asn Asn Gln Gly Leu Thr Pro Leu His Leu Ala Cys Gln
            260                 265                 270         
Leu Gly Lys Gln Glu Met Val Arg Val Leu Leu Leu Cys Asn Ala Arg
        275                 280                 285             
Cys Asn Ile Met Gly Pro Asn Gly Tyr Pro Ile His Ser Ala Met Lys
    290                 295                 300                 
Phe Ser Gln Lys Gly Cys Ala Glu Met Ile Ile Ser Met Asp Ser Ser
305                 310                 315                 320 
Gln Ile His Ser Lys Asp Pro Arg Tyr Gly Ala Ser Pro Leu His Trp
                325                 330                 335     
Ala Lys Asn Ala Glu Met Ala Arg Met Leu Leu Lys Arg Gly Cys Asn
            340                 345                 350         
Val Asn Ser Thr Ser Ser Ala Gly Asn Thr Ala Leu His Val Ala Val
        355                 360                 365             
Met Arg Asn Arg Phe Asp Cys Ala Ile Val Leu Leu Thr His Gly Ala
    370                 375                 380                 
Asn Ala Asp Ala Arg Gly Glu His Gly Asn Thr Pro Leu His Leu Ala
385                 390                 395                 400 
Met Ser Lys Asp Asn Val Glu Met Ile Lys Ala Leu Ile Val Phe Gly
                405                 410                 415     
Ala Glu Val Asp Thr Pro Asn Asp Phe Gly Glu Thr Pro Thr Phe Leu
            420                 425                 430         
Ala Ser Lys Ile Gly Arg Leu Val Thr Arg Lys Ala Ile Leu Thr Leu
        435                 440                 445             
Leu Arg Thr Val Gly Ala Glu Tyr Cys Phe Pro Pro Ile His Gly Val
    450                 455                 460                 
Pro Ala Glu Gln Gly Ser Ala Ala Pro His His Pro Phe Ser Leu Glu
465                 470                 475                 480 
Arg Ala Gln Pro Pro Pro Ile Ser Leu Asn Asn Leu Glu Leu Gln Asp
                485                 490                 495     
Leu Met His Ile Ser Arg Ala Arg Lys Pro Ala Phe Ile Leu Gly Ser
            500                 505                 510         
Met Arg Asp Glu Lys Arg Thr His Asp His Leu Leu Cys Leu Asp Gly
        515                 520                 525             
Gly Gly Val Lys Gly Leu Ile Ile Ile Gln Leu Leu Ile Ala Ile Glu
    530                 535                 540                 
Lys Ala Ser Gly Val Ala Thr Lys Asp Leu Phe Asp Trp Val Ala Gly
545                 550                 555                 560 
Thr Ser Thr Gly Gly Ile Leu Ala Leu Ala Ile Leu His Ser Lys Ser
                565                 570                 575     
Met Ala Tyr Met Arg Gly Met Tyr Phe Arg Met Lys Asp Glu Val Phe
            580                 585                 590         
Arg Gly Ser Arg Pro Tyr Glu Ser Gly Pro Leu Glu Glu Phe Leu Lys
        595                 600                 605             
Arg Glu Phe Gly Glu His Thr Lys Met Thr Asp Val Arg Lys Pro Lys
    610                 615                 620                 
Val Met Leu Thr Gly Thr Leu Ser Asp Arg Gln Pro Ala Glu Leu His
625                 630                 635                 640 
Leu Phe Arg Asn Tyr Asp Ala Pro Glu Thr Val Arg Glu Pro Arg Phe
                645                 650                 655     
Asn Gln Asn Val Asn Leu Arg Pro Pro Ala Gln Pro Ser Asp Gln Leu
            660                 665                 670         
Val Trp Arg Ala Ala Arg Ser Ser Gly Ala Ala Pro Thr Tyr Phe Arg
        675                 680                 685             
Pro Asn Gly Arg Phe Leu Asp Gly Gly Leu Leu Ala Asn Asn Pro Thr
    690                 695                 700                 
Leu Asp Ala Met Thr Glu Ile His Glu Tyr Asn Gln Asp Leu Ile Arg
705                 710                 715                 720 
Lys Gly Gln Ala Asn Lys Val Lys Lys Leu Ser Ile Val Val Ser Leu
                725                 730                 735     
Gly Thr Gly Arg Ser Pro Gln Val Pro Val Thr Cys Val Asp Val Phe
            740                 745                 750         
Arg Pro Ser Asn Pro Trp Glu Leu Ala Lys Thr Val Phe Gly Ala Lys
        755                 760                 765             
Glu Leu Gly Lys Met Val Val Asp Cys Cys Thr Asp Pro Asp Gly Arg
    770                 775                 780                 
Ala Val Asp Arg Ala Arg Ala Trp Cys Glu Met Val Gly Ile Gln Tyr
785                 790                 795                 800 
Phe Arg Leu Asn Pro Gln Leu Gly Thr Asp Ile Met Leu Asp Glu Val
                805                 810                 815     
Ser Asp Thr Val Leu Val Asn Ala Leu Trp Glu Thr Glu Val Tyr Ile
            820                 825                 830         
Tyr Glu His Arg Glu Glu Phe Gln Lys Leu Ile Gln Leu Leu Leu Ser
        835                 840                 845             
Pro
    


<210> 6032
<211> 453
<212> PRT
<213> Homo sapiens

<400> 6032
Met Lys Leu Leu Thr Arg Ala Gly Ser Phe Ser Arg Phe Tyr Ser Leu
 1               5                  10                  15      
Lys Val Ala Pro Lys Val Lys Ala Thr Ala Ala Pro Ala Gly Ala Pro
            20                  25                  30          
Pro Gln Pro Gln Asp Leu Glu Phe Thr Lys Leu Pro Asn Gly Leu Val
        35                  40                  45              
Ile Ala Ser Leu Glu Asn Tyr Ser Pro Val Ser Arg Ile Gly Leu Phe
    50                  55                  60                  
Ile Lys Ala Gly Ser Arg Tyr Glu Asp Phe Ser Asn Leu Gly Thr Thr
65                  70                  75                  80  
His Leu Leu Arg Leu Thr Ser Ser Leu Thr Thr Lys Gly Ala Ser Ser
                85                  90                  95      
Phe Lys Ile Thr Arg Gly Ile Glu Ala Val Gly Gly Lys Leu Ser Val
            100                 105                 110         
Thr Ala Thr Arg Glu Asn Met Ala Tyr Thr Val Glu Cys Leu Arg Gly
        115                 120                 125             
Asp Val Asp Ile Leu Met Glu Phe Leu Leu Asn Val Thr Thr Ala Pro
    130                 135                 140                 
Glu Phe Arg Arg Trp Glu Val Ala Asp Leu Gln Pro Gln Leu Lys Ile
145                 150                 155                 160 
Asp Lys Ala Val Ala Phe Gln Asn Pro Gln Thr His Val Ile Glu Asn
                165                 170                 175     
Leu His Ala Ala Ala Tyr Arg Asn Ala Leu Ala Asn Pro Leu Tyr Cys
            180                 185                 190         
Pro Asp Tyr Arg Ile Gly Lys Val Thr Ser Glu Glu Leu His Tyr Phe
        195                 200                 205             
Val Gln Asn His Phe Thr Ser Ala Arg Met Ala Leu Ile Gly Leu Gly
    210                 215                 220                 
Val Ser His Pro Val Leu Lys Gln Val Ala Glu Gln Phe Leu Asn Met
225                 230                 235                 240 
Arg Gly Gly Leu Gly Leu Ser Gly Ala Lys Ala Asn Tyr Arg Gly Gly
                245                 250                 255     
Glu Ile Arg Glu Gln Asn Gly Asp Ser Leu Val His Ala Ala Phe Val
            260                 265                 270         
Ala Glu Ser Ala Val Ala Gly Ser Ala Glu Ala Asn Ala Phe Ser Val
        275                 280                 285             
Leu Gln His Val Leu Gly Ala Gly Pro His Val Lys Arg Gly Ser Asn
    290                 295                 300                 
Thr Thr Ser His Leu His Gln Ala Val Ala Lys Ala Thr Gln Gln Pro
305                 310                 315                 320 
Phe Asp Val Ser Ala Phe Asn Ala Ser Tyr Ser Asp Ser Gly Leu Phe
                325                 330                 335     
Gly Ile Tyr Thr Ile Ser Gln Ala Thr Ala Ala Gly Asp Val Ile Lys
            340                 345                 350         
Ala Ala Tyr Asn Gln Val Lys Thr Ile Ala Gln Gly Asn Leu Ser Asn
        355                 360                 365             
Thr Asp Val Gln Ala Ala Lys Asn Lys Leu Lys Ala Gly Tyr Leu Met
    370                 375                 380                 
Ser Val Glu Ser Ser Glu Cys Phe Leu Glu Glu Val Gly Ser Gln Ala
385                 390                 395                 400 
Leu Val Ala Gly Ser Tyr Met Pro Pro Ser Thr Val Leu Gln Gln Ile
                405                 410                 415     
Asp Ser Val Ala Asn Ala Asp Ile Ile Asn Ala Ala Lys Lys Phe Val
            420                 425                 430         
Ser Gly Gln Lys Ser Met Ala Ala Ser Gly Asn Leu Gly His Thr Pro
        435                 440                 445             
Phe Val Asp Glu Leu
    450             


<210> 6033
<211> 3361
<212> PRT
<213> Homo sapiens

<400> 6033
Met Val Thr His Trp Leu Pro Trp Arg Gln Met Asn Leu Leu Leu Gln
 1               5                  10                  15      
Thr Leu Arg Ala Asn Leu Lys Ser His Gln Gln Trp Leu Pro Glu Leu
            20                  25                  30          
Ser Lys Ser Ser Leu Cys Tyr Gln Val Thr Ser Ser Arg Leu Gly Arg
        35                  40                  45              
Ala Leu Ala Glu Leu Phe Gly Leu Leu Val Lys Leu Cys Val Gly Ser
    50                  55                  60                  
Pro Val Arg Gln Arg Arg Ser His His Ala Ala Ser Thr Thr Thr Ala
65                  70                  75                  80  
Pro Thr Pro Ala Ala Arg Ser Thr Ala Ser Ala Leu Thr Lys Leu Leu
                85                  90                  95      
Thr Lys Gly Leu Ser Trp Gln Pro Pro Pro Tyr Thr Pro Thr Pro Arg
            100                 105                 110         
Phe Arg Leu Thr Phe Phe Ile Cys Ser Val Gly Phe Thr Ser Pro Met
        115                 120                 125             
Leu Phe Asp Glu Arg Lys Tyr Pro Tyr His Leu Met Leu Gln Lys Phe
    130                 135                 140                 
Leu Cys Ser Gly Gly His Asn Ala Leu Phe Glu Thr Phe Asn Trp Ala
145                 150                 155                 160 
Leu Ser Met Gly Gly Lys Val Pro Val Ser Glu Gly Leu Glu His Ser
                165                 170                 175     
Asp Leu Pro Asp Gly Thr Gly Glu Phe Leu Asp Ala Trp Leu Met Leu
            180                 185                 190         
Val Glu Lys Met Val Asn Pro Thr Thr Val Leu Glu Ser Pro His Ser
        195                 200                 205             
Leu Pro Ala Lys Leu Pro Gly Gly Val Gln Asn Phe Pro Gln Phe Ser
    210                 215                 220                 
Ala Leu Arg Phe Leu Val Val Thr Gln Lys Ala Ala Phe Thr Cys Ile
225                 230                 235                 240 
Lys Asn Leu Trp Asn Arg Lys Pro Leu Lys Val Tyr Gly Gly Arg Met
                245                 250                 255     
Ala Glu Ser Met Leu Ala Ile Leu Cys His Ile Leu Arg Gly Glu Pro
            260                 265                 270         
Val Ile Arg Glu Arg Leu Ser Lys Glu Lys Glu Gly Ser Arg Gly Glu
        275                 280                 285             
Glu Asp Thr Gly Gln Glu Glu Gly Gly Ser Arg Arg Glu Pro Gln Val
    290                 295                 300                 
Asn Gln Gln Gln Leu Gln Gln Leu Met Asp Met Gly Phe Thr Arg Glu
305                 310                 315                 320 
His Ala Met Glu Ala Leu Leu Asn Thr Ser Thr Met Glu Gln Ala Thr
                325                 330                 335     
Glu Tyr Leu Leu Thr His Pro Pro Pro Ile Met Gly Gly Val Val Arg
            340                 345                 350         
Asp Leu Ser Met Ser Glu Glu Asp Gln Met Met Arg Ala Ile Ala Met
        355                 360                 365             
Ser Leu Gly Gln Asp Ile Pro Met Asp Gln Arg Ala Glu Ser Pro Glu
    370                 375                 380                 
Glu Val Ala Cys Arg Lys Glu Glu Glu Glu Arg Lys Ala Arg Glu Lys
385                 390                 395                 400 
Gln Glu Glu Glu Glu Ala Lys Cys Leu Glu Lys Phe Gln Asp Ala Asp
                405                 410                 415     
Pro Leu Glu Gln Asp Glu Leu His Thr Phe Thr Asp Thr Met Leu Pro
            420                 425                 430         
Gly Cys Phe His Leu Leu Asp Glu Leu Pro Asp Thr Val Tyr Arg Val
        435                 440                 445             
Cys Asp Leu Ile Met Thr Ala Ile Lys Arg Asn Gly Ala Asp Tyr Arg
    450                 455                 460                 
Asp Met Ile Leu Lys Gln Val Val Asn Gln Val Trp Glu Ala Ala Asp
465                 470                 475                 480 
Val Leu Ile Lys Ala Ala Leu Pro Leu Thr Thr Ser Asp Thr Lys Thr
                485                 490                 495     
Val Ser Glu Trp Ile Ser Gln Met Ala Thr Leu Pro Gln Ala Ser Asn
            500                 505                 510         
Leu Ala Thr Arg Ile Leu Leu Leu Thr Leu Leu Phe Glu Glu Leu Lys
        515                 520                 525             
Leu Pro Cys Ala Trp Val Val Glu Ser Ser Gly Ile Leu Asn Val Leu
    530                 535                 540                 
Ile Lys Leu Leu Glu Val Val Gln Pro Cys Leu Gln Ala Ala Lys Glu
545                 550                 555                 560 
Gln Lys Glu Val Gln Thr Pro Lys Trp Ile Thr Pro Val Leu Leu Leu
                565                 570                 575     
Ile Asp Phe Tyr Glu Lys Thr Ala Ile Ser Ser Lys Arg Arg Ala Gln
            580                 585                 590         
Met Thr Lys Tyr Leu Gln Ser Asn Ser Asn Asn Trp Arg Trp Phe Asp
        595                 600                 605             
Asp Arg Ser Gly Arg Trp Cys Ser Tyr Ser Ala Ser Asn Asn Ser Thr
    610                 615                 620                 
Ile Asp Ser Ala Trp Lys Ser Gly Glu Thr Ser Val Arg Phe Thr Ala
625                 630                 635                 640 
Gly Arg Arg Arg Tyr Thr Val Gln Phe Thr Thr Met Val Gln Val Asn
                645                 650                 655     
Glu Glu Thr Gly Asn Arg Arg Pro Val Met Leu Thr Leu Leu Arg Val
            660                 665                 670         
Pro Arg Leu Asn Lys Asn Ser Lys Asn Ser Asn Gly Gln Glu Leu Glu
        675                 680                 685             
Lys Thr Leu Glu Glu Ser Lys Glu Met Asp Ile Lys Arg Lys Glu Asn
    690                 695                 700                 
Lys Gly Asn Asp Thr Pro Leu Ala Leu Glu Ser Thr Asn Thr Glu Lys
705                 710                 715                 720 
Glu Thr Ser Leu Glu Glu Thr Lys Ile Gly Glu Ile Leu Ile Gln Gly
                725                 730                 735     
Leu Thr Glu Asp Met Val Thr Val Leu Ile Arg Ala Cys Val Ser Met
            740                 745                 750         
Leu Gly Val Pro Val Asp Pro Asp Thr Leu His Ala Thr Leu Arg Leu
        755                 760                 765             
Cys Leu Arg Leu Thr Arg Asp His Lys Tyr Ala Met Met Phe Ala Glu
    770                 775                 780                 
Leu Lys Ser Thr Arg Met Ile Leu Asn Leu Thr Gln Ser Ser Gly Phe
785                 790                 795                 800 
Asn Gly Phe Thr Pro Leu Val Thr Leu Leu Leu Arg His Ile Ile Glu
                805                 810                 815     
Asp Pro Cys Thr Leu Arg His Thr Met Glu Lys Val Val Arg Ser Ala
            820                 825                 830         
Ala Thr Ser Gly Ala Gly Ser Thr Thr Ser Gly Val Val Ser Gly Ser
        835                 840                 845             
Leu Gly Ser Arg Glu Ile Asn Tyr Ile Leu Arg Val Leu Gly Pro Ala
    850                 855                 860                 
Ala Cys Arg Asn Pro Asp Ile Phe Thr Glu Val Ala Asn Cys Cys Ile
865                 870                 875                 880 
Arg Ile Ala Leu Pro Ala Pro Arg Gly Ser Gly Thr Ala Ser Asp Asp
                885                 890                 895     
Glu Phe Glu Asn Leu Arg Ile Lys Gly Pro Asn Ala Val Gln Leu Val
            900                 905                 910         
Lys Thr Thr Pro Leu Lys Pro Ser Pro Leu Pro Val Ile Pro Asp Thr
        915                 920                 925             
Ile Lys Glu Val Ile Tyr Asp Met Leu Asn Ala Leu Ala Ala Tyr His
    930                 935                 940                 
Ala Pro Glu Glu Ala Asp Lys Ser Asp Pro Lys Pro Gly Val Met Thr
945                 950                 955                 960 
Gln Glu Val Gly Gln Leu Leu Gln Asp Met Gly Asp Asp Val Tyr Gln
                965                 970                 975     
Gln Tyr Arg Ser Leu Thr Arg Gln Ser Ser Asp Phe Asp Thr Gln Ser
            980                 985                 990         
Gly Phe Ser Ile Asn Ser Gln Val Phe Ala Ala Asp Gly Ala Ser Thr
        995                 1000                1005            
Glu Thr Ser Ala Ser Gly Thr Ser Gln Gly Glu Ala Ser Thr Pro Glu
    1010                1015                1020                
Glu Ser Arg Asp Gly Lys Lys Asp Lys Glu Gly Asp Arg Ala Ser Glu
1025                1030                1035                1040
Glu Gly Lys Gln Lys Gly Lys Gly Ser Lys Pro Leu Met Pro Thr Ser
                1045                1050                1055    
Thr Ile Leu Arg Leu Leu Ala Glu Leu Val Arg Ser Tyr Val Gly Ile
            1060                1065                1070        
Ala Thr Leu Ile Ala Asn Tyr Ser Tyr Thr Val Gly Gln Ser Glu Leu
        1075                1080                1085            
Ile Lys Glu Asp Cys Ser Val Leu Ala Phe Val Leu Asp His Leu Leu
    1090                1095                1100                
Pro His Thr Gln Asn Ala Glu Asp Lys Asp Thr Pro Ala Leu Ala Arg
1105                1110                1115                1120
Leu Phe Leu Ala Ser Leu Ala Ala Ala Gly Ser Gly Thr Asp Ala Gln
                1125                1130                1135    
Val Ala Leu Val Asn Glu Val Lys Ala Ala Leu Gly Arg Ala Leu Ala
            1140                1145                1150        
Met Ala Glu Ser Thr Glu Lys His Ala Arg Leu Gln Ala Val Met Cys
        1155                1160                1165            
Ile Ile Ser Thr Ile Met Glu Ser Cys Pro Ser Thr Ser Ser Phe Tyr
    1170                1175                1180                
Ser Ser Ala Thr Ala Lys Thr Gln His Asn Gly Met Asn Asn Ile Ile
1185                1190                1195                1200
Arg Leu Phe Leu Lys Lys Gly Leu Val Asn Asp Leu Ala Arg Val Pro
                1205                1210                1215    
His Ser Leu Asp Leu Ser Ser Pro Asn Met Ala Asn Thr Val Asn Ala
            1220                1225                1230        
Ala Leu Lys Pro Leu Glu Thr Leu Ser Arg Ile Val Asn Gln Pro Ser
        1235                1240                1245            
Ser Leu Phe Gly Ser Lys Ser Ala Ser Ser Lys Asn Lys Ser Glu Gln
    1250                1255                1260                
Asp Ala Gln Gly Ala Ser Gln Asp Ser Ser Ser Asn Gln Gln Asp Pro
1265                1270                1275                1280
Gly Glu Pro Gly Glu Ala Glu Val Gln Glu Glu Asp His Asp Val Thr
                1285                1290                1295    
Gln Thr Glu Val Ala Asp Gly Asp Ile Met Asp Gly Glu Ala Glu Thr
            1300                1305                1310        
Asp Ser Val Val Ile Ala Gly Gln Pro Glu Val Leu Ser Ser Gln Glu
        1315                1320                1325            
Met Gln Val Glu Asn Glu Leu Glu Asp Leu Ile Asp Glu Leu Leu Glu
    1330                1335                1340                
Arg Asp Gly Gly Ser Gly Asn Ser Thr Ile Ile Val Ser Arg Ser Gly
1345                1350                1355                1360
Glu Asp Glu Ser Gln Glu Asp Val Leu Met Asp Glu Ala Pro Ser Asn
                1365                1370                1375    
Leu Ser Gln Ala Ser Thr Leu Gln Ala Asn Arg Glu Asp Ser Met Asn
            1380                1385                1390        
Ile Leu Asp Pro Glu Asp Glu Glu Glu His Thr Gln Glu Glu Asp Ser
        1395                1400                1405            
Ser Gly Ser Asn Glu Asp Glu Asp Asp Ser Gln Asp Glu Glu Glu Glu
    1410                1415                1420                
Glu Glu Glu Asp Glu Glu Asp Asp Gln Glu Asp Asp Glu Gly Glu Glu
1425                1430                1435                1440
Gly Asp Glu Asp Asp Asp Asp Asp Gly Ser Glu Met Glu Leu Asp Glu
                1445                1450                1455    
Asp Tyr Pro Asp Met Asn Ala Ser Pro Leu Val Arg Phe Glu Arg Phe
            1460                1465                1470        
Asp Arg Glu Asp Asp Leu Ile Ile Glu Phe Asp Asn Met Phe Ser Ser
        1475                1480                1485            
Ala Thr Asp Ile Pro Pro Ser Pro Gly Asn Ile Pro Thr Thr His Pro
    1490                1495                1500                
Leu Met Val Arg His Ala Asp His Ser Ser Leu Thr Leu Gly Ser Gly
1505                1510                1515                1520
Ser Ser Thr Thr Arg Leu Thr Gln Gly Ile Gly Arg Ser Gln Arg Thr
                1525                1530                1535    
Leu Arg Gln Leu Thr Ala Asn Thr Gly His Thr Ile His Val His Tyr
            1540                1545                1550        
Pro Gly Asn Arg Gln Pro Asn Pro Pro Leu Ile Leu Gln Arg Leu Leu
        1555                1560                1565            
Gly Pro Ser Ala Ala Ala Asp Ile Leu Gln Leu Ser Ser Ser Leu Pro
    1570                1575                1580                
Leu Gln Ser Arg Gly Arg Ala Arg Leu Leu Val Gly Asn Asp Asp Val
1585                1590                1595                1600
His Ile Ile Ala Arg Ser Asp Asp Glu Leu Leu Asp Asp Phe Phe His
                1605                1610                1615    
Asp Gln Ser Thr Ala Thr Ser Gln Ala Gly Lys Phe Val Cys Ile Pro
            1620                1625                1630        
Thr Ala Leu Thr Arg Trp Thr Glu Glu Cys Lys Val Leu Asp Ala Glu
        1635                1640                1645            
Ser Met His Asp Cys Val Ser Val Val Lys Val Ser Ile Val Asn His
    1650                1655                1660                
Leu Glu Phe Leu Arg Asp Glu Glu Leu Glu Glu Arg Arg Glu Lys Arg
1665                1670                1675                1680
Arg Lys Gln Leu Ala Glu Glu Glu Thr Lys Ile Thr Asp Lys Gly Lys
                1685                1690                1695    
Glu Asp Lys Glu Asn Arg Asp Gln Ser Ala Gln Cys Thr Ala Ser Lys
            1700                1705                1710        
Ser Asn Asp Ser Thr Glu Gln Asn Leu Ser Asp Gly Thr Pro Met Pro
        1715                1720                1725            
Asp Ser Tyr Pro Thr Thr Pro Ser Ser Thr Asp Ala Ala Thr Ser Glu
    1730                1735                1740                
Ser Lys Glu Thr Leu Gly Thr Leu Gln Ser Ser Gln Gln Gln Pro Thr
1745                1750                1755                1760
Leu Pro Thr Pro Pro Ala Leu Gly Glu Val Pro Gln Glu Leu Gln Ser
                1765                1770                1775    
Pro Ala Gly Glu Gly Gly Ser Ser Thr Gln Leu Leu Met Pro Val Glu
            1780                1785                1790        
Pro Glu Glu Leu Gly Pro Thr Arg Pro Ser Gly Glu Ala Glu Thr Thr
        1795                1800                1805            
Gln Met Glu Leu Ser Pro Ala Pro Thr Ile Thr Ser Leu Ser Pro Glu
    1810                1815                1820                
Arg Ala Glu Asp Ser Asp Ala Leu Thr Ala Val Ser Ser Gln Leu Glu
1825                1830                1835                1840
Gly Ser Pro Met Asp Thr Ser Ser Leu Ala Ser Cys Thr Leu Glu Glu
                1845                1850                1855    
Ala Val Gly Asp Thr Ser Ala Ala Gly Ser Ser Glu Gln Pro Arg Ala
            1860                1865                1870        
Gly Ser Ser Thr Pro Gly Asp Ala Pro Pro Ala Val Ala Glu Val Gln
        1875                1880                1885            
Gly Arg Ser Asp Gly Ser Gly Glu Ser Ala Gln Pro Pro Glu Asp Ser
    1890                1895                1900                
Ser Pro Pro Ala Ser Ser Glu Ser Ser Ser Thr Arg Asp Ser Ala Val
1905                1910                1915                1920
Ala Ile Ser Gly Ala Asp Ser Arg Gly Ile Leu Glu Glu Pro Leu Pro
                1925                1930                1935    
Ser Thr Ser Ser Glu Glu Glu Asp Pro Leu Ala Gly Ile Ser Leu Pro
            1940                1945                1950        
Glu Gly Val Asp Pro Ser Phe Leu Ala Ala Leu Pro Asp Asp Ile Arg
        1955                1960                1965            
Arg Glu Val Leu Gln Asn Gln Leu Gly Ile Arg Pro Pro Thr Arg Thr
    1970                1975                1980                
Ala Pro Ser Thr Asn Ser Ser Ala Pro Ala Val Val Gly Asn Pro Gly
1985                1990                1995                2000
Val Thr Glu Val Ser Pro Glu Phe Leu Ala Ala Leu Pro Pro Ala Ile
                2005                2010                2015    
Gln Glu Glu Val Leu Ala Gln Gln Arg Ala Glu Gln Gln Arg Arg Glu
            2020                2025                2030        
Leu Ala Gln Asn Ala Ser Ser Asp Thr Pro Met Asp Pro Val Thr Phe
        2035                2040                2045            
Ile Gln Thr Leu Pro Ser Asp Leu Arg Arg Ser Val Leu Glu Asp Met
    2050                2055                2060                
Glu Asp Ser Val Leu Ala Val Met Pro Pro Asp Ile Ala Ala Glu Ala
2065                2070                2075                2080
Gln Ala Leu Arg Arg Glu Gln Glu Ala Arg Gln Arg Gln Leu Met His
                2085                2090                2095    
Glu Arg Leu Phe Gly His Ser Ser Thr Ser Ala Leu Ser Ala Ile Leu
            2100                2105                2110        
Arg Ser Pro Ala Phe Thr Ser Arg Leu Ser Gly Asn Arg Gly Val Gln
        2115                2120                2125            
Tyr Thr Arg Leu Ala Val Gln Arg Gly Gly Thr Phe Gln Met Gly Gly
    2130                2135                2140                
Ser Ser Ser His Asn Arg Pro Ser Gly Ser Asn Val Asp Thr Leu Leu
2145                2150                2155                2160
Arg Leu Arg Gly Arg Leu Leu Leu Asp His Glu Ala Leu Ser Cys Leu
                2165                2170                2175    
Leu Val Leu Leu Phe Val Asp Glu Pro Lys Leu Asn Thr Ser Arg Leu
            2180                2185                2190        
His Arg Val Leu Arg Asn Leu Cys Tyr His Ala Gln Thr Arg His Trp
        2195                2200                2205            
Val Ile Arg Ser Leu Leu Ser Ile Leu Gln Arg Ser Ser Glu Ser Glu
    2210                2215                2220                
Leu Cys Ile Glu Thr Pro Lys Leu Thr Thr Ser Glu Glu Lys Gly Lys
2225                2230                2235                2240
Lys Ser Ser Lys Ser Cys Gly Ser Ser Ser His Glu Asn Arg Pro Leu
                2245                2250                2255    
Asp Leu Leu His Lys Met Glu Ser Lys Ser Ser Asn Gln Leu Ser Trp
            2260                2265                2270        
Leu Ser Val Ser Met Asp Ala Ala Leu Gly Cys Arg Thr Asn Ile Phe
        2275                2280                2285            
Gln Ile Gln Arg Ser Gly Gly Arg Lys His Thr Glu Lys His Ala Ser
    2290                2295                2300                
Gly Gly Ser Thr Val His Ile His Pro Gln Ala Ala Pro Val Val Cys
2305                2310                2315                2320
Arg His Val Leu Asp Thr Leu Ile Gln Leu Ala Lys Val Phe Pro Ser
                2325                2330                2335    
His Phe Thr Gln Gln Arg Thr Lys Glu Thr Asn Cys Glu Ser Asp Arg
            2340                2345                2350        
Glu Arg Gly Asn Lys Ala Cys Ser Pro Cys Ser Ser Gln Ser Ser Ser
        2355                2360                2365            
Ser Gly Ile Cys Thr Asp Phe Trp Asp Leu Leu Val Lys Leu Asp Asn
    2370                2375                2380                
Met Asn Val Ser Arg Lys Gly Lys Asn Ser Val Lys Ser Val Pro Val
2385                2390                2395                2400
Ser Ala Gly Gly Glu Gly Glu Thr Ser Pro Tyr Ser Leu Glu Ala Ser
                2405                2410                2415    
Pro Leu Gly Gln Leu Met Asn Met Leu Ser His Pro Val Ile Arg Arg
            2420                2425                2430        
Ser Ser Leu Leu Thr Glu Lys Leu Leu Arg Leu Leu Ser Leu Ile Ser
        2435                2440                2445            
Ile Ala Leu Pro Glu Asn Lys Val Ser Glu Ala Gln Ala Asn Ser Gly
    2450                2455                2460                
Ser Gly Ala Ser Ser Thr Thr Thr Ala Thr Ser Thr Thr Ser Thr Thr
2465                2470                2475                2480
Thr Thr Thr Ala Ala Ser Thr Thr Pro Thr Pro Pro Thr Ala Pro Thr
                2485                2490                2495    
Pro Val Thr Ser Ala Pro Ala Leu Val Ala Ala Thr Ala Ile Ser Thr
            2500                2505                2510        
Ile Val Val Ala Ala Ser Thr Thr Val Thr Thr Pro Thr Thr Ala Thr
        2515                2520                2525            
Thr Thr Val Ser Ile Ser Pro Thr Thr Lys Gly Ser Lys Ser Pro Ala
    2530                2535                2540                
Lys Val Ser Asp Gly Gly Ser Ser Ser Thr Asp Phe Lys Met Val Ser
2545                2550                2555                2560
Ser Gly Leu Thr Glu Asn Gln Leu Gln Leu Ser Val Glu Val Leu Thr
                2565                2570                2575    
Ser His Ser Cys Ser Glu Glu Gly Leu Glu Asp Ala Ala Asn Val Leu
            2580                2585                2590        
Leu Gln Leu Ser Arg Gly Asp Ser Gly Thr Arg Asp Thr Val Leu Lys
        2595                2600                2605            
Leu Leu Leu Asn Gly Ala Arg His Leu Gly Tyr Thr Leu Cys Lys Gln
    2610                2615                2620                
Ile Gly Thr Leu Leu Ala Glu Leu Arg Glu Tyr Asn Leu Glu Gln Gln
2625                2630                2635                2640
Arg Arg Ala Gln Cys Glu Thr Leu Ser Pro Asp Gly Leu Pro Glu Glu
                2645                2650                2655    
Gln Pro Gln Thr Thr Lys Leu Lys Gly Lys Met Gln Ser Arg Phe Asp
            2660                2665                2670        
Met Ala Glu Asn Val Val Ile Val Ala Ser Gln Lys Arg Pro Leu Gly
        2675                2680                2685            
Gly Arg Glu Leu Gln Leu Pro Ser Met Ser Met Leu Thr Ser Lys Thr
    2690                2695                2700                
Ser Thr Gln Lys Phe Phe Leu Arg Val Leu Gln Val Ile Ile Gln Leu
2705                2710                2715                2720
Arg Asp Asp Thr Arg Arg Ala Asn Lys Lys Ala Lys Gln Thr Gly Arg
                2725                2730                2735    
Leu Gly Ser Ser Gly Leu Gly Ser Ala Ser Ser Ile Gln Ala Ala Val
            2740                2745                2750        
Arg Gln Leu Glu Ala Glu Ala Asp Ala Ile Ile Gln Met Val Arg Glu
        2755                2760                2765            
Gly Gln Arg Ala Arg Arg Gln Gln Gln Ala Ala Thr Ser Glu Ser Ser
    2770                2775                2780                
Gln Ser Glu Ala Ser Val Arg Arg Glu Glu Ser Pro Met Asp Val Asp
2785                2790                2795                2800
Gln Pro Ser Pro Ser Ala Gln Asp Thr Gln Ser Ile Ala Ser Asp Gly
                2805                2810                2815    
Thr Pro Gln Gly Glu Lys Glu Lys Glu Glu Arg Pro Pro Glu Leu Pro
            2820                2825                2830        
Leu Leu Ser Glu Gln Leu Ser Leu Asp Glu Leu Trp Asp Met Leu Gly
        2835                2840                2845            
Glu Cys Leu Lys Glu Leu Glu Glu Ser His Asp Gln His Ala Val Leu
    2850                2855                2860                
Val Leu Gln Pro Ala Val Glu Ala Phe Phe Leu Val His Ala Thr Glu
2865                2870                2875                2880
Arg Glu Ser Lys Pro Pro Val Arg Asp Thr Arg Glu Ser Gln Leu Ala
                2885                2890                2895    
His Ile Lys Asp Glu Pro Pro Pro Leu Ser Pro Ala Pro Leu Thr Pro
            2900                2905                2910        
Ala Thr Pro Ser Ser Leu Asp Pro Phe Phe Ser Arg Glu Pro Ser Ser
        2915                2920                2925            
Met His Ile Ser Ser Ser Leu Pro Pro Asp Thr Gln Lys Phe Leu Arg
    2930                2935                2940                
Phe Ala Glu Thr His Arg Thr Val Leu Asn Gln Ile Leu Arg Gln Ser
2945                2950                2955                2960
Thr Thr His Leu Ala Asp Gly Pro Phe Ala Val Leu Val Asp Tyr Ile
                2965                2970                2975    
Arg Val Leu Asp Phe Asp Val Lys Arg Lys Tyr Phe Arg Gln Glu Leu
            2980                2985                2990        
Glu Arg Leu Asp Glu Gly Leu Arg Lys Glu Asp Met Ala Val His Val
        2995                3000                3005            
Arg Arg Asp His Val Phe Glu Asp Ser Tyr Arg Glu Leu His Arg Lys
    3010                3015                3020                
Ser Pro Glu Glu Met Lys Asn Arg Leu Tyr Ile Val Phe Glu Gly Glu
3025                3030                3035                3040
Glu Gly Gln Asp Ala Gly Gly Leu Leu Arg Glu Trp Tyr Met Ile Ile
                3045                3050                3055    
Ser Arg Glu Met Phe Asn Pro Met Tyr Ala Leu Phe Arg Thr Ser Pro
            3060                3065                3070        
Gly Asp Arg Val Thr Tyr Thr Ile Asn Pro Ser Ser His Cys Asn Pro
        3075                3080                3085            
Asn His Leu Ser Tyr Phe Lys Phe Val Gly Arg Ile Val Ala Lys Ala
    3090                3095                3100                
Val Tyr Asp Asn Arg Leu Leu Glu Cys Tyr Phe Thr Arg Ser Phe Tyr
3105                3110                3115                3120
Lys His Ile Leu Gly Lys Ser Val Arg Tyr Thr Asp Met Glu Ser Glu
                3125                3130                3135    
Asp Tyr His Phe Tyr Gln Gly Leu Val Tyr Leu Leu Glu Asn Asp Val
            3140                3145                3150        
Ser Thr Leu Gly Tyr Asp Leu Thr Phe Ser Thr Glu Val Gln Glu Phe
        3155                3160                3165            
Gly Val Cys Glu Val Arg Asp Leu Lys Pro Asn Gly Ala Asn Ile Leu
    3170                3175                3180                
Val Thr Glu Glu Asn Lys Lys Glu Tyr Val His Leu Val Cys Gln Met
3185                3190                3195                3200
Arg Met Thr Gly Ala Ile Arg Lys Gln Leu Ala Ala Phe Leu Glu Gly
                3205                3210                3215    
Phe Tyr Glu Ile Ile Pro Lys Arg Leu Ile Ser Ile Phe Thr Glu Gln
            3220                3225                3230        
Glu Leu Glu Leu Leu Ile Ser Gly Leu Pro Thr Ile Asp Ile Asp Asp
        3235                3240                3245            
Leu Lys Ser Asn Thr Glu Tyr His Lys Tyr Gln Ser Asn Ser Ile Gln
    3250                3255                3260                
Ile Gln Trp Phe Trp Arg Ala Leu Arg Ser Phe Asp Gln Ala Asp Arg
3265                3270                3275                3280
Ala Lys Phe Leu Gln Phe Val Thr Gly Thr Ser Lys Val Pro Leu Gln
                3285                3290                3295    
Gly Phe Ala Ala Leu Glu Gly Met Asn Gly Ile Gln Lys Phe Gln Ile
            3300                3305                3310        
His Arg Asp Asp Arg Ser Thr Asp Arg Leu Pro Ser Ala His Thr Cys
        3315                3320                3325            
Phe Asn Gln Leu Asp Leu Pro Ala Tyr Glu Ser Phe Glu Lys Leu Arg
    3330                3335                3340                
His Met Leu Leu Leu Ala Ile Gln Glu Cys Ser Glu Gly Phe Gly Leu
3345                3350                3355                3360
Ala
    


<210> 6034
<211> 739
<212> PRT
<213> Homo sapiens

<400> 6034
Met Glu Gly Gly Gly Gly Arg Asp Glu Pro Ser Ala Cys Arg Ala Gly
 1               5                  10                  15      
Asp Val Asn Met Asp Asp Pro Lys Lys Glu Asp Ile Leu Leu Leu Ala
            20                  25                  30          
Asp Glu Lys Phe Asp Phe Asp Leu Ser Leu Ser Ser Ser Ser Ala Asn
        35                  40                  45              
Glu Asp Asp Glu Val Phe Phe Gly Pro Phe Gly His Lys Glu Arg Cys
    50                  55                  60                  
Ile Ala Ala Ser Leu Glu Leu Asn Asn Pro Val Pro Glu Gln Pro Pro
65                  70                  75                  80  
Leu Pro Thr Ser Glu Ser Pro Phe Ala Trp Ser Pro Leu Ala Gly Glu
                85                  90                  95      
Lys Phe Val Glu Val Tyr Lys Glu Ala His Leu Leu Ala Leu His Ile
            100                 105                 110         
Glu Ser Ser Ser Arg Asn Gln Ala Ala Gln Ala Ala Lys Pro Glu Asp
        115                 120                 125             
Pro Arg Ser Gln Gly Val Glu Arg Phe Ile Gln Glu Ser Lys Leu Lys
    130                 135                 140                 
Ile Asn Leu Phe Glu Lys Glu Lys Glu Met Lys Lys Ser Pro Thr Ser
145                 150                 155                 160 
Leu Lys Arg Glu Thr Tyr Tyr Leu Ser Asp Ser Pro Leu Leu Gly Pro
                165                 170                 175     
Pro Val Gly Glu Pro Arg Leu Leu Ala Ser Ser Pro Ala Leu Pro Ser
            180                 185                 190         
Ser Gly Ala Gln Ala Arg Leu Thr Arg Ala Pro Gly Pro Pro His Ser
        195                 200                 205             
Ala His Ala Leu Pro Arg Glu Ser Cys Thr Ala His Ala Ala Ser Gln
    210                 215                 220                 
Ala Ala Thr Gln Arg Lys Pro Gly Thr Lys Leu Leu Leu Pro Arg Ala
225                 230                 235                 240 
Ala Ser Val Arg Gly Arg Ser Ile Pro Gly Ala Ala Glu Lys Pro Lys
                245                 250                 255     
Lys Glu Ile Pro Ala Ser Pro Ser Arg Thr Lys Ile Pro Ala Glu Lys
            260                 265                 270         
Glu Ser His Arg Asp Val Leu Pro Asp Lys Pro Ala Pro Gly Ala Val
        275                 280                 285             
Asn Val Pro Ala Ala Gly Ser His Leu Gly Gln Gly Lys Arg Ala Ile
    290                 295                 300                 
Pro Val Pro Asn Lys Leu Gly Leu Lys Lys Thr Leu Leu Lys Ala Pro
305                 310                 315                 320 
Gly Ser Thr Ser Asn Leu Ala Arg Lys Ser Ser Ser Gly Pro Val Trp
                325                 330                 335     
Ser Gly Ala Ser Ser Ala Cys Thr Ser Pro Ala Val Gly Lys Ala Lys
            340                 345                 350         
Ser Ser Glu Phe Ala Ser Ile Pro Ala Asn Ser Ser Arg Pro Leu Ser
        355                 360                 365             
Asn Ile Ser Lys Ser Gly Arg Met Gly Pro Ala Met Leu Arg Pro Ala
    370                 375                 380                 
Leu Pro Ala Gly Pro Val Gly Ala Ser Ser Trp Gln Ala Lys Arg Val
385                 390                 395                 400 
Asp Val Ser Glu Leu Ala Ala Glu Gln Leu Thr Ala Pro Pro Ser Ala
                405                 410                 415     
Ser Pro Thr Gln Pro Gln Thr Pro Glu Gly Gly Gly Gln Trp Leu Asn
            420                 425                 430         
Ser Ser Cys Ala Trp Ser Glu Ser Ser Gln Leu Asn Lys Thr Arg Ser
        435                 440                 445             
Ile Arg Arg Arg Asp Ser Cys Leu Asn Ser Lys Thr Lys Val Met Pro
    450                 455                 460                 
Thr Pro Thr Asn Gln Phe Lys Ile Pro Lys Phe Ser Ile Gly Asp Ser
465                 470                 475                 480 
Pro Asp Ser Ser Thr Pro Lys Leu Ser Arg Ala Gln Arg Pro Gln Ser
                485                 490                 495     
Cys Thr Ser Val Gly Arg Val Thr Val His Ser Thr Pro Val Arg Arg
            500                 505                 510         
Ser Ser Gly Pro Ala Pro Gln Ser Leu Leu Ser Ala Trp Arg Val Ser
        515                 520                 525             
Ala Leu Pro Thr Pro Ala Ser Arg Arg Cys Ser Gly Leu Pro Pro Met
    530                 535                 540                 
Thr Pro Lys Thr Met Pro Arg Ala Val Gly Ser Pro Leu Cys Val Pro
545                 550                 555                 560 
Ala Arg Arg Arg Ser Ser Glu Pro Arg Lys Asn Ser Ala Met Arg Thr
                565                 570                 575     
Glu Pro Thr Arg Glu Ser Asn Arg Lys Thr Asp Ser Arg Leu Val Asp
            580                 585                 590         
Val Ser Pro Asp Arg Gly Ser Pro Pro Ser Arg Val Pro Gln Ala Leu
        595                 600                 605             
Asn Phe Ser Pro Glu Glu Ser Asp Ser Thr Phe Ser Lys Ser Thr Ala
    610                 615                 620                 
Thr Glu Val Ala Arg Glu Glu Ala Lys Pro Gly Gly Asp Ala Ala Pro
625                 630                 635                 640 
Ser Glu Ala Leu Leu Val Asp Ile Lys Leu Glu Pro Leu Ala Val Thr
                645                 650                 655     
Pro Asp Ala Ala Ser Gln Pro Leu Ile Asp Leu Pro Leu Ile Asp Phe
            660                 665                 670         
Cys Asp Thr Pro Glu Ala His Val Ala Val Gly Ser Glu Ser Arg Pro
        675                 680                 685             
Leu Ile Asp Leu Met Thr Asn Thr Pro Asp Met Asn Lys Asn Val Ala
    690                 695                 700                 
Lys Pro Ser Pro Val Val Gly Gln Leu Ile Asp Leu Ser Ser Pro Leu
705                 710                 715                 720 
Ile Gln Leu Ser Pro Glu Ala Asp Lys Glu Asn Val Asp Ser Pro Leu
                725                 730                 735     
Leu Lys Phe
            


<210> 6035
<211> 333
<212> PRT
<213> Homo sapiens

<400> 6035
Met Ala Ala Ala Ala Ala Gly Thr Ala Thr Ser Gln Arg Phe Phe Gln
 1               5                  10                  15      
Ser Phe Ser Asp Ala Leu Ile Asp Glu Asp Pro Gln Ala Ala Leu Glu
            20                  25                  30          
Glu Leu Thr Lys Ala Leu Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr
        35                  40                  45              
Cys Gln Arg Ala Tyr Cys His Ile Leu Leu Gly Asn Tyr Cys Val Ala
    50                  55                  60                  
Val Ala Asp Ala Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr
65                  70                  75                  80  
Ala Met Leu Arg Lys Gly Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala
                85                  90                  95      
Ala Ala Leu Glu Thr Phe Thr Glu Gly Gln Lys Leu Asp Ser Ala Asp
            100                 105                 110         
Ala Asn Phe Ser Val Trp Ile Lys Arg Cys Gln Glu Ala Gln Asn Gly
        115                 120                 125             
Ser Glu Ser Glu Val Trp Thr His Gln Ser Lys Ile Lys Tyr Asp Trp
    130                 135                 140                 
Tyr Gln Thr Glu Ser Gln Val Val Ile Thr Leu Met Ile Lys Asn Val
145                 150                 155                 160 
Gln Lys Asn Asp Val Asn Val Glu Phe Ser Glu Lys Glu Leu Ser Ala
                165                 170                 175     
Leu Val Lys Leu Pro Ser Gly Glu Asp Tyr Asn Leu Lys Leu Glu Leu
            180                 185                 190         
Leu His Pro Ile Ile Pro Glu Gln Ser Thr Phe Lys Val Leu Ser Thr
        195                 200                 205             
Lys Ile Glu Ile Lys Leu Lys Lys Pro Glu Ala Val Arg Trp Glu Lys
    210                 215                 220                 
Leu Glu Gly Gln Gly Asp Val Pro Thr Pro Lys Gln Phe Val Ala Asp
225                 230                 235                 240 
Val Lys Asn Leu Tyr Pro Ser Ser Ser Pro Tyr Thr Arg Asn Trp Asp
                245                 250                 255     
Lys Leu Val Gly Glu Ile Lys Glu Glu Glu Lys Asn Glu Lys Leu Glu
            260                 265                 270         
Gly Asp Ala Ala Leu Asn Arg Leu Phe Gln Gln Ile Tyr Ser Asp Gly
        275                 280                 285             
Ser Asp Glu Val Lys Arg Ala Met Asn Lys Ser Phe Met Glu Ser Gly
    290                 295                 300                 
Gly Thr Val Leu Ser Thr Asn Trp Ser Asp Val Gly Lys Arg Lys Val
305                 310                 315                 320 
Glu Ile Asn Pro Pro Asp Asp Met Glu Trp Lys Lys Tyr
                325                 330             


<210> 6036
<211> 1479
<212> PRT
<213> Homo sapiens

<400> 6036
Met Ala Pro Leu Leu Gly Arg Lys Pro Phe Pro Leu Val Lys Pro Leu
 1               5                  10                  15      
Pro Gly Glu Glu Pro Leu Phe Thr Ile Pro His Thr Gln Glu Ala Phe
            20                  25                  30          
Arg Thr Arg Glu Glu Tyr Glu Ala Arg Leu Glu Arg Tyr Ser Glu Arg
        35                  40                  45              
Ile Trp Thr Cys Lys Ser Thr Gly Ser Ser Gln Leu Thr His Lys Glu
    50                  55                  60                  
Ala Trp Glu Glu Glu Gln Glu Val Ala Glu Leu Leu Lys Glu Glu Phe
65                  70                  75                  80  
Pro Ala Trp Tyr Glu Lys Leu Val Leu Glu Met Val His His Asn Thr
                85                  90                  95      
Ala Ser Leu Glu Lys Leu Val Asp Thr Ala Trp Leu Glu Ile Met Thr
            100                 105                 110         
Lys Tyr Ala Val Gly Glu Glu Cys Asp Phe Glu Val Gly Lys Glu Lys
        115                 120                 125             
Met Leu Lys Val Lys Ile Val Lys Ile His Pro Leu Glu Lys Val Asp
    130                 135                 140                 
Glu Glu Ala Thr Glu Lys Lys Ser Asp Gly Ala Cys Asp Ser Pro Ser
145                 150                 155                 160 
Ser Asp Lys Glu Asn Ser Ser Gln Ile Ala Gln Asp His Gln Lys Lys
                165                 170                 175     
Glu Thr Val Val Lys Glu Asp Glu Gly Arg Arg Glu Ser Ile Asn Asp
            180                 185                 190         
Arg Ala Arg Arg Ser Pro Arg Lys Leu Pro Thr Ser Leu Lys Lys Gly
        195                 200                 205             
Glu Arg Lys Trp Ala Pro Pro Lys Phe Leu Pro His Lys Tyr Asp Val
    210                 215                 220                 
Lys Leu Gln Asn Glu Asp Lys Ile Ile Ser Asn Val Pro Ala Asp Ser
225                 230                 235                 240 
Leu Ile Arg Thr Glu Arg Pro Pro Asn Lys Glu Ile Val Arg Tyr Phe
                245                 250                 255     
Ile Arg His Asn Ala Leu Arg Ala Gly Thr Gly Glu Asn Ala Pro Trp
            260                 265                 270         
Val Val Glu Asp Glu Leu Val Lys Lys Tyr Ser Leu Pro Ser Lys Phe
        275                 280                 285             
Ser Asp Phe Leu Leu Asp Pro Tyr Lys Tyr Met Thr Leu Asn Pro Ser
    290                 295                 300                 
Thr Lys Arg Lys Asn Thr Gly Ser Pro Asp Arg Lys Pro Ser Lys Lys
305                 310                 315                 320 
Ser Lys Thr Asp Asn Ser Ser Leu Ser Ser Pro Leu Asn Pro Lys Leu
                325                 330                 335     
Trp Cys His Val His Leu Lys Lys Ser Leu Ser Gly Ser Pro Leu Lys
            340                 345                 350         
Val Lys Asn Ser Lys Asn Ser Lys Ser Pro Glu Glu His Leu Glu Glu
        355                 360                 365             
Met Met Lys Met Met Ser Pro Asn Lys Leu His Thr Asn Phe His Ile
    370                 375                 380                 
Pro Lys Lys Gly Pro Pro Ala Lys Lys Pro Gly Lys His Ser Asp Lys
385                 390                 395                 400 
Pro Leu Lys Ala Lys Gly Arg Ser Lys Gly Ile Leu Asn Gly Gln Lys
                405                 410                 415     
Ser Thr Gly Asn Ser Lys Ser Pro Lys Lys Gly Leu Lys Thr Pro Lys
            420                 425                 430         
Thr Lys Met Lys Gln Met Thr Leu Leu Asp Met Ala Lys Gly Thr Gln
        435                 440                 445             
Lys Met Thr Arg Ala Pro Arg Asn Ser Gly Gly Thr Pro Arg Thr Ser
    450                 455                 460                 
Ser Lys Pro His Lys His Leu Pro Pro Ala Ala Leu His Leu Ile Ala
465                 470                 475                 480 
Tyr Tyr Lys Glu Asn Lys Asp Arg Glu Asp Lys Arg Ser Ala Leu Ser
                485                 490                 495     
Cys Val Ile Ser Lys Thr Ala Arg Leu Leu Ser Ser Glu Asp Arg Ala
            500                 505                 510         
Arg Leu Pro Glu Glu Leu Arg Ser Leu Val Gln Lys Arg Tyr Glu Leu
        515                 520                 525             
Leu Glu His Lys Lys Arg Trp Ala Ser Met Ser Glu Glu Gln Arg Lys
    530                 535                 540                 
Glu Tyr Leu Lys Lys Lys Arg Glu Glu Leu Lys Lys Lys Leu Lys Glu
545                 550                 555                 560 
Lys Ala Lys Glu Arg Arg Glu Lys Glu Met Leu Glu Arg Leu Glu Lys
                565                 570                 575     
Gln Lys Arg Tyr Glu Asp Gln Glu Leu Thr Gly Lys Asn Leu Pro Ala
            580                 585                 590         
Phe Arg Leu Val Asp Thr Pro Glu Gly Leu Pro Asn Thr Leu Phe Gly
        595                 600                 605             
Asp Val Ala Met Val Val Glu Phe Leu Ser Cys Tyr Ser Gly Leu Leu
    610                 615                 620                 
Leu Pro Asp Ala Gln Tyr Pro Ile Thr Ala Val Ser Leu Met Glu Ala
625                 630                 635                 640 
Leu Ser Ala Asp Lys Gly Gly Phe Leu Tyr Leu Asn Arg Val Leu Val
                645                 650                 655     
Ile Leu Leu Gln Asp Glu Ile Ala Glu Asp Tyr Gly Glu Leu Gly Met
            660                 665                 670         
Lys Leu Ser Glu Ile Pro Leu Thr Leu His Ser Val Ser Glu Leu Val
        675                 680                 685             
Arg Leu Cys Leu Arg Arg Ser Asp Val Gln Glu Glu Ser Glu Gly Ser
    690                 695                 700                 
Asp Thr Asp Asp Asn Lys Asp Ser Ala Ala Phe Glu Asp Asn Glu Val
705                 710                 715                 720 
Gln Asp Glu Phe Leu Glu Lys Leu Glu Thr Ser Glu Phe Phe Glu Leu
                725                 730                 735     
Thr Ser Glu Glu Lys Leu Gln Ile Leu Thr Ala Leu Cys His Arg Ile
            740                 745                 750         
Leu Met Thr Tyr Ser Val Gln Asp His Met Glu Thr Arg Gln Gln Met
        755                 760                 765             
Ser Ala Glu Leu Trp Lys Glu Arg Leu Ala Val Leu Lys Glu Glu Asn
    770                 775                 780                 
Asp Lys Lys Arg Ala Glu Lys Gln Lys Arg Lys Glu Met Glu Ala Lys
785                 790                 795                 800 
Asn Lys Glu Asn Gly Lys Val Glu Asn Gly Leu Gly Lys Thr Asp Arg
                805                 810                 815     
Lys Lys Glu Ile Val Lys Phe Glu Pro Gln Val Asp Thr Glu Ala Glu
            820                 825                 830         
Asp Met Ile Ser Ala Val Lys Ser Arg Arg Leu Leu Ala Ile Gln Ala
        835                 840                 845             
Lys Lys Glu Arg Glu Ile Gln Glu Arg Glu Met Lys Val Lys Leu Glu
    850                 855                 860                 
Arg Gln Ala Glu Glu Glu Arg Ile Arg Lys His Lys Ala Ala Ala Glu
865                 870                 875                 880 
Lys Ala Phe Gln Glu Gly Ile Ala Lys Ala Lys Leu Val Met Arg Arg
                885                 890                 895     
Thr Pro Ile Gly Thr Asp Arg Asn His Asn Arg Tyr Trp Leu Phe Ser
            900                 905                 910         
Asp Glu Val Pro Gly Leu Phe Ile Glu Lys Gly Trp Val His Asp Ser
        915                 920                 925             
Ile Asp Tyr Arg Phe Asn His His Cys Lys Asp His Thr Val Ser Gly
    930                 935                 940                 
Asp Glu Asp Tyr Cys Pro Arg Ser Lys Lys Ala Asn Leu Gly Lys Asn
945                 950                 955                 960 
Ala Ser Met Asn Thr Gln His Gly Thr Ala Thr Glu Val Ala Val Glu
                965                 970                 975     
Thr Thr Thr Pro Lys Gln Gly Gln Asn Leu Trp Phe Leu Cys Asp Ser
            980                 985                 990         
Gln Lys Glu Leu Asp Glu Leu Leu Asn Cys Leu His Pro Gln Gly Ile
        995                 1000                1005            
Arg Glu Ser Gln Leu Lys Glu Arg Leu Glu Lys Arg Tyr Gln Asp Ile
    1010                1015                1020                
Ile His Ser Ile His Leu Ala Arg Lys Pro Asn Leu Gly Leu Lys Ser
1025                1030                1035                1040
Cys Asp Gly Asn Gln Glu Leu Leu Asn Phe Leu Arg Ser Asp Leu Ile
                1045                1050                1055    
Glu Val Ala Thr Arg Leu Gln Lys Gly Gly Leu Gly Tyr Val Glu Glu
            1060                1065                1070        
Thr Ser Glu Phe Glu Ala Arg Val Ile Ser Leu Glu Lys Leu Lys Asp
        1075                1080                1085            
Phe Gly Glu Cys Val Ile Ala Leu Gln Ala Ser Val Ile Lys Lys Phe
    1090                1095                1100                
Leu Gln Gly Phe Met Ala Pro Lys Gln Lys Arg Arg Lys Leu Gln Ser
1105                1110                1115                1120
Glu Asp Ser Ala Lys Thr Glu Glu Val Asp Glu Glu Lys Lys Met Val
                1125                1130                1135    
Glu Glu Ala Lys Val Ala Ser Ala Leu Glu Lys Trp Lys Thr Ala Ile
            1140                1145                1150        
Arg Glu Ala Gln Thr Phe Ser Arg Met His Val Leu Leu Gly Met Leu
        1155                1160                1165            
Asp Ala Cys Ile Lys Trp Asp Met Ser Ala Glu Asn Ala Arg Cys Lys
    1170                1175                1180                
Val Cys Arg Lys Lys Gly Glu Asp Asp Lys Leu Ile Leu Cys Asp Glu
1185                1190                1195                1200
Cys Asn Lys Ala Phe His Leu Phe Cys Leu Arg Pro Ala Leu Tyr Glu
                1205                1210                1215    
Val Pro Asp Gly Glu Trp Gln Cys Pro Ala Cys Gln Pro Ala Thr Ala
            1220                1225                1230        
Arg Arg Asn Ser Arg Gly Arg Asn Tyr Thr Glu Glu Ser Ala Ser Glu
        1235                1240                1245            
Asp Ser Glu Asp Asp Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu
    1250                1255                1260                
Glu Glu Glu Glu Glu Asp Tyr Glu Val Ala Gly Leu Arg Leu Arg Pro
1265                1270                1275                1280
Arg Lys Thr Ile Arg Gly Lys His Ser Val Ile Pro Pro Ala Ala Arg
                1285                1290                1295    
Ser Gly Arg Arg Pro Gly Lys Lys Pro His Ser Thr Arg Arg Ser Gln
            1300                1305                1310        
Pro Lys Ala Pro Pro Val Asp Asp Ala Glu Val Asp Glu Leu Val Leu
        1315                1320                1325            
Gln Thr Lys Arg Ser Ser Arg Arg Gln Ser Leu Glu Leu Gln Lys Cys
    1330                1335                1340                
Glu Glu Ile Leu His Lys Ile Val Lys Tyr Arg Phe Ser Trp Pro Phe
1345                1350                1355                1360
Arg Glu Pro Val Thr Arg Asp Glu Ala Glu Asp Tyr Tyr Asp Val Ile
                1365                1370                1375    
Thr His Pro Met Asp Phe Gln Thr Val Gln Asn Lys Cys Ser Cys Gly
            1380                1385                1390        
Ser Tyr Arg Ser Val Gln Glu Phe Leu Thr Asp Met Lys Gln Val Phe
        1395                1400                1405            
Thr Asn Ala Glu Val Tyr Asn Cys Arg Gly Ser His Val Leu Ser Cys
    1410                1415                1420                
Met Val Lys Thr Glu Gln Cys Leu Val Ala Leu Leu His Lys His Leu
1425                1430                1435                1440
Pro Gly His Pro Tyr Val Arg Arg Lys Arg Lys Lys Phe Pro Asp Arg
                1445                1450                1455    
Leu Ala Glu Asp Glu Gly Asp Ser Glu Pro Glu Ala Val Gly Gln Ser
            1460                1465                1470        
Arg Gly Arg Arg Gln Lys Lys
        1475                


<210> 6037
<211> 1483
<212> PRT
<213> Homo sapiens

<400> 6037
Met Ala Pro Leu Leu Gly Arg Lys Pro Phe Pro Leu Val Lys Pro Leu
 1               5                  10                  15      
Pro Gly Glu Glu Pro Leu Phe Thr Ile Pro His Thr Gln Glu Ala Phe
            20                  25                  30          
Arg Thr Arg Glu Glu Tyr Glu Ala Arg Leu Glu Arg Tyr Ser Glu Arg
        35                  40                  45              
Ile Trp Thr Cys Lys Ser Thr Gly Ser Ser Gln Leu Thr His Lys Glu
    50                  55                  60                  
Ala Trp Glu Glu Glu Gln Glu Val Ala Glu Leu Leu Lys Glu Glu Phe
65                  70                  75                  80  
Pro Ala Trp Tyr Glu Lys Leu Val Leu Glu Met Val His His Asn Thr
                85                  90                  95      
Ala Ser Leu Glu Lys Leu Val Asp Thr Ala Trp Leu Glu Ile Met Thr
            100                 105                 110         
Lys Tyr Ala Val Gly Glu Glu Cys Asp Phe Glu Val Gly Lys Glu Lys
        115                 120                 125             
Met Leu Lys Val Lys Ile Val Lys Ile His Pro Leu Glu Lys Val Asp
    130                 135                 140                 
Glu Glu Ala Thr Glu Lys Lys Ser Asp Gly Ala Cys Asp Ser Pro Ser
145                 150                 155                 160 
Ser Asp Lys Glu Asn Ser Ser Gln Ile Ala Gln Asp His Gln Lys Lys
                165                 170                 175     
Glu Thr Val Val Lys Glu Asp Glu Gly Arg Arg Glu Ser Ile Asn Asp
            180                 185                 190         
Arg Ala Arg Arg Ser Pro Arg Lys Leu Pro Thr Ser Leu Lys Lys Gly
        195                 200                 205             
Glu Arg Lys Trp Ala Pro Pro Lys Phe Leu Pro His Lys Tyr Asp Val
    210                 215                 220                 
Lys Leu Gln Asn Glu Asp Lys Ile Ile Ser Asn Val Pro Ala Asp Ser
225                 230                 235                 240 
Leu Ile Arg Thr Glu Arg Pro Pro Asn Lys Glu Ile Val Arg Tyr Phe
                245                 250                 255     
Ile Arg His Asn Ala Leu Arg Ala Gly Thr Gly Glu Asn Ala Pro Trp
            260                 265                 270         
Val Val Glu Asp Glu Leu Val Lys Lys Tyr Ser Leu Pro Ser Lys Phe
        275                 280                 285             
Ser Asp Phe Leu Leu Asp Pro Tyr Lys Tyr Met Thr Leu Asn Pro Ser
    290                 295                 300                 
Thr Lys Arg Lys Asn Thr Gly Ser Pro Asp Arg Lys Pro Ser Lys Lys
305                 310                 315                 320 
Ser Lys Thr Asp Asn Ser Ser Leu Ser Ser Pro Leu Asn Pro Lys Leu
                325                 330                 335     
Trp Cys His Val His Leu Lys Lys Ser Leu Ser Gly Ser Pro Leu Lys
            340                 345                 350         
Val Lys Asn Ser Lys Asn Ser Lys Ser Pro Glu Glu His Leu Glu Glu
        355                 360                 365             
Met Met Lys Met Met Ser Pro Asn Lys Leu His Thr Asn Phe His Ile
    370                 375                 380                 
Pro Lys Lys Gly Pro Pro Ala Lys Lys Pro Gly Lys His Ser Asp Lys
385                 390                 395                 400 
Pro Leu Lys Ala Lys Gly Arg Ser Lys Gly Ile Leu Asn Gly Gln Lys
                405                 410                 415     
Ser Thr Gly Asn Ser Lys Ser Pro Lys Lys Gly Leu Lys Thr Pro Lys
            420                 425                 430         
Thr Lys Met Lys Gln Met Thr Leu Leu Asp Met Ala Lys Gly Thr Gln
        435                 440                 445             
Lys Met Thr Arg Ala Pro Arg Asn Ser Gly Gly Thr Pro Arg Thr Ser
    450                 455                 460                 
Ser Lys Pro His Lys His Leu Pro Pro Ala Ala Leu His Leu Ile Ala
465                 470                 475                 480 
Tyr Tyr Lys Glu Asn Lys Asp Arg Glu Asp Lys Arg Ser Ala Leu Ser
                485                 490                 495     
Cys Val Ile Ser Lys Thr Ala Arg Leu Leu Ser Ser Glu Asp Arg Ala
            500                 505                 510         
Arg Leu Pro Glu Glu Leu Arg Ser Leu Val Gln Lys Arg Tyr Glu Leu
        515                 520                 525             
Leu Glu His Lys Lys Arg Trp Ala Ser Met Ser Glu Glu Gln Arg Lys
    530                 535                 540                 
Glu Tyr Leu Lys Lys Lys Arg Glu Glu Leu Lys Lys Lys Leu Lys Glu
545                 550                 555                 560 
Lys Ala Lys Glu Arg Arg Glu Lys Glu Met Leu Glu Arg Leu Glu Lys
                565                 570                 575     
Gln Lys Arg Tyr Glu Asp Gln Glu Leu Thr Gly Lys Asn Leu Pro Ala
            580                 585                 590         
Phe Arg Leu Val Asp Thr Pro Glu Gly Leu Pro Asn Thr Leu Phe Gly
        595                 600                 605             
Asp Val Ala Met Val Val Glu Phe Leu Ser Cys Tyr Ser Gly Leu Leu
    610                 615                 620                 
Leu Pro Asp Ala Gln Tyr Pro Ile Thr Ala Val Ser Leu Met Glu Ala
625                 630                 635                 640 
Leu Ser Ala Asp Lys Gly Gly Phe Leu Tyr Leu Asn Arg Val Leu Val
                645                 650                 655     
Ile Leu Leu Gln Thr Leu Leu Gln Asp Glu Ile Ala Glu Asp Tyr Gly
            660                 665                 670         
Glu Leu Gly Met Lys Leu Ser Glu Ile Pro Leu Thr Leu His Ser Val
        675                 680                 685             
Ser Glu Leu Val Arg Leu Cys Leu Arg Arg Ser Asp Val Gln Glu Glu
    690                 695                 700                 
Ser Glu Gly Ser Asp Thr Asp Asp Asn Lys Asp Ser Ala Ala Phe Glu
705                 710                 715                 720 
Asp Asn Glu Val Gln Asp Glu Phe Leu Glu Lys Leu Glu Thr Ser Glu
                725                 730                 735     
Phe Phe Glu Leu Thr Ser Glu Glu Lys Leu Gln Ile Leu Thr Ala Leu
            740                 745                 750         
Cys His Arg Ile Leu Met Thr Tyr Ser Val Gln Asp His Met Glu Thr
        755                 760                 765             
Arg Gln Gln Met Ser Ala Glu Leu Trp Lys Glu Arg Leu Ala Val Leu
    770                 775                 780                 
Lys Glu Glu Asn Asp Lys Lys Arg Ala Glu Lys Gln Lys Arg Lys Glu
785                 790                 795                 800 
Met Glu Ala Lys Asn Lys Glu Asn Gly Lys Val Glu Asn Gly Leu Gly
                805                 810                 815     
Lys Thr Asp Arg Lys Lys Glu Ile Val Lys Phe Glu Pro Gln Val Asp
            820                 825                 830         
Thr Glu Ala Glu Asp Met Ile Ser Ala Val Lys Ser Arg Arg Leu Leu
        835                 840                 845             
Ala Ile Gln Ala Lys Lys Glu Arg Glu Ile Gln Glu Arg Glu Met Lys
    850                 855                 860                 
Val Lys Leu Glu Arg Gln Ala Glu Glu Glu Arg Ile Arg Lys His Lys
865                 870                 875                 880 
Ala Ala Ala Glu Lys Ala Phe Gln Glu Gly Ile Ala Lys Ala Lys Leu
                885                 890                 895     
Val Met Arg Arg Thr Pro Ile Gly Thr Asp Arg Asn His Asn Arg Tyr
            900                 905                 910         
Trp Leu Phe Ser Asp Glu Val Pro Gly Leu Phe Ile Glu Lys Gly Trp
        915                 920                 925             
Val His Asp Ser Ile Asp Tyr Arg Phe Asn His His Cys Lys Asp His
    930                 935                 940                 
Thr Val Ser Gly Asp Glu Asp Tyr Cys Pro Arg Ser Lys Lys Ala Asn
945                 950                 955                 960 
Leu Gly Lys Asn Ala Ser Met Asn Thr Gln His Gly Thr Ala Thr Glu
                965                 970                 975     
Val Ala Val Glu Thr Thr Thr Pro Lys Gln Gly Gln Asn Leu Trp Phe
            980                 985                 990         
Leu Cys Asp Ser Gln Lys Glu Leu Asp Glu Leu Leu Asn Cys Leu His
        995                 1000                1005            
Pro Gln Gly Ile Arg Glu Ser Gln Leu Lys Glu Arg Leu Glu Lys Arg
    1010                1015                1020                
Tyr Gln Asp Ile Ile His Ser Ile His Leu Ala Arg Lys Pro Asn Leu
1025                1030                1035                1040
Gly Leu Lys Ser Cys Asp Gly Asn Gln Glu Leu Leu Asn Phe Leu Arg
                1045                1050                1055    
Ser Asp Leu Ile Glu Val Ala Thr Arg Leu Gln Lys Gly Gly Leu Gly
            1060                1065                1070        
Tyr Val Glu Glu Thr Ser Glu Phe Glu Ala Arg Val Ile Ser Leu Glu
        1075                1080                1085            
Lys Leu Lys Asp Phe Gly Glu Cys Val Ile Ala Leu Gln Ala Ser Val
    1090                1095                1100                
Ile Lys Lys Phe Leu Gln Gly Phe Met Ala Pro Lys Gln Lys Arg Arg
1105                1110                1115                1120
Lys Leu Gln Ser Glu Asp Ser Ala Lys Thr Glu Glu Val Asp Glu Glu
                1125                1130                1135    
Lys Lys Met Val Glu Glu Ala Lys Val Ala Ser Ala Leu Glu Lys Trp
            1140                1145                1150        
Lys Thr Ala Ile Arg Glu Ala Gln Thr Phe Ser Arg Met His Val Leu
        1155                1160                1165            
Leu Gly Met Leu Asp Ala Cys Ile Lys Trp Asp Met Ser Ala Glu Asn
    1170                1175                1180                
Ala Arg Cys Lys Val Cys Arg Lys Lys Gly Glu Asp Asp Lys Leu Ile
1185                1190                1195                1200
Leu Cys Asp Glu Cys Asn Lys Ala Phe His Leu Phe Cys Leu Arg Pro
                1205                1210                1215    
Ala Leu Tyr Glu Val Pro Asp Gly Glu Trp Gln Cys Pro Ala Cys Gln
            1220                1225                1230        
Pro Ala Thr Ala Arg Arg Asn Ser Arg Gly Arg Asn Tyr Thr Glu Glu
        1235                1240                1245            
Ser Ala Ser Glu Asp Ser Glu Asp Asp Glu Ser Asp Glu Glu Glu Glu
    1250                1255                1260                
Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Tyr Glu Val Ala Gly Leu
1265                1270                1275                1280
Arg Leu Arg Pro Arg Lys Thr Ile Arg Gly Lys His Ser Val Ile Pro
                1285                1290                1295    
Pro Ala Ala Arg Ser Gly Arg Arg Pro Gly Lys Lys Pro His Ser Thr
            1300                1305                1310        
Arg Arg Ser Gln Pro Lys Ala Pro Pro Val Asp Asp Ala Glu Val Asp
        1315                1320                1325            
Glu Leu Val Leu Gln Thr Lys Arg Ser Ser Arg Arg Gln Ser Leu Glu
    1330                1335                1340                
Leu Gln Lys Cys Glu Glu Ile Leu His Met Ile Val Lys Tyr Arg Phe
1345                1350                1355                1360
Ser Trp Pro Phe Arg Glu Pro Val Thr Arg Asp Glu Ala Glu Asp Tyr
                1365                1370                1375    
Tyr Asp Val Ile Thr His Pro Met Asp Phe Gln Thr Val Gln Asn Lys
            1380                1385                1390        
Cys Ser Cys Gly Ser Tyr Arg Ser Val Gln Glu Phe Leu Thr Asp Met
        1395                1400                1405            
Lys Gln Val Phe Thr Asn Ala Glu Val Tyr Asn Cys Arg Gly Ser His
    1410                1415                1420                
Val Leu Ser Cys Met Val Lys Thr Glu Gln Cys Leu Val Ala Leu Leu
1425                1430                1435                1440
His Lys His Leu Pro Gly His Pro Tyr Val Arg Arg Lys Arg Lys Lys
                1445                1450                1455    
Phe Pro Asp Arg Leu Ala Glu Asp Glu Gly Asp Ser Glu Pro Glu Ala
            1460                1465                1470        
Val Gly Gln Ser Arg Gly Arg Arg Gln Lys Lys
        1475                1480            


<210> 6038
<211> 1483
<212> PRT
<213> Homo sapiens

<400> 6038
Met Ala Pro Leu Leu Gly Arg Lys Pro Phe Pro Leu Val Lys Pro Leu
 1               5                  10                  15      
Pro Gly Glu Glu Pro Leu Phe Thr Ile Pro His Thr Gln Glu Ala Phe
            20                  25                  30          
Arg Thr Arg Glu Glu Tyr Glu Ala Arg Leu Glu Arg Tyr Ser Glu Arg
        35                  40                  45              
Ile Trp Thr Cys Lys Ser Thr Gly Ser Ser Gln Leu Thr His Lys Glu
    50                  55                  60                  
Ala Trp Glu Glu Glu Gln Glu Val Ala Glu Leu Leu Lys Glu Glu Phe
65                  70                  75                  80  
Pro Ala Trp Tyr Glu Lys Leu Val Leu Glu Met Val His His Asn Thr
                85                  90                  95      
Ala Ser Leu Glu Lys Leu Val Asp Thr Ala Trp Leu Glu Ile Met Thr
            100                 105                 110         
Lys Tyr Ala Val Gly Glu Glu Cys Asp Phe Glu Val Gly Lys Glu Lys
        115                 120                 125             
Met Leu Lys Val Lys Ile Val Lys Ile His Pro Leu Glu Lys Val Asp
    130                 135                 140                 
Glu Glu Ala Thr Glu Lys Lys Ser Asp Gly Ala Cys Asp Ser Pro Ser
145                 150                 155                 160 
Ser Asp Lys Glu Asn Ser Ser Gln Ile Ala Gln Asp His Gln Lys Lys
                165                 170                 175     
Glu Thr Val Val Lys Glu Asp Glu Gly Arg Arg Glu Ser Ile Asn Asp
            180                 185                 190         
Arg Ala Arg Arg Ser Pro Arg Lys Leu Pro Thr Ser Leu Lys Lys Gly
        195                 200                 205             
Glu Arg Lys Trp Ala Pro Pro Lys Phe Leu Pro His Lys Tyr Asp Val
    210                 215                 220                 
Lys Leu Gln Asn Glu Asp Lys Ile Ile Ser Asn Val Pro Ala Asp Ser
225                 230                 235                 240 
Leu Ile Arg Thr Glu Arg Pro Pro Asn Lys Glu Ile Val Arg Tyr Phe
                245                 250                 255     
Ile Arg His Asn Ala Leu Arg Ala Gly Thr Gly Glu Asn Ala Pro Trp
            260                 265                 270         
Val Val Glu Asp Glu Leu Val Lys Lys Tyr Ser Leu Pro Ser Lys Phe
        275                 280                 285             
Ser Asp Phe Leu Leu Asp Pro Tyr Lys Tyr Met Thr Leu Asn Pro Ser
    290                 295                 300                 
Thr Lys Arg Lys Asn Thr Gly Ser Pro Asp Arg Lys Pro Ser Lys Lys
305                 310                 315                 320 
Ser Lys Thr Asp Asn Ser Ser Leu Ser Ser Pro Leu Asn Pro Lys Leu
                325                 330                 335     
Trp Cys His Val His Leu Lys Lys Ser Leu Ser Gly Ser Pro Leu Lys
            340                 345                 350         
Val Lys Asn Ser Lys Asn Ser Lys Ser Pro Glu Glu His Leu Glu Glu
        355                 360                 365             
Met Met Lys Met Met Ser Pro Asn Lys Leu His Thr Asn Phe His Ile
    370                 375                 380                 
Pro Lys Lys Gly Pro Pro Ala Lys Lys Pro Gly Lys His Ser Asp Lys
385                 390                 395                 400 
Pro Leu Lys Ala Lys Gly Arg Ser Lys Gly Ile Leu Asn Gly Gln Lys
                405                 410                 415     
Ser Thr Gly Asn Ser Lys Ser Pro Lys Lys Gly Leu Lys Thr Pro Lys
            420                 425                 430         
Thr Lys Met Lys Gln Met Thr Leu Leu Asp Met Ala Lys Gly Thr Gln
        435                 440                 445             
Lys Met Thr Arg Ala Pro Arg Asn Ser Gly Gly Thr Pro Arg Thr Ser
    450                 455                 460                 
Ser Lys Pro His Lys His Leu Pro Pro Ala Ala Leu His Leu Ile Ala
465                 470                 475                 480 
Tyr Tyr Lys Glu Asn Lys Asp Arg Glu Asp Lys Arg Ser Ala Leu Ser
                485                 490                 495     
Cys Val Ile Ser Lys Thr Ala Arg Leu Leu Ser Ser Glu Asp Arg Ala
            500                 505                 510         
Arg Leu Pro Glu Glu Leu Arg Ser Leu Val Gln Lys Arg Tyr Glu Leu
        515                 520                 525             
Leu Glu His Lys Lys Arg Trp Ala Ser Met Ser Glu Glu Gln Arg Lys
    530                 535                 540                 
Glu Tyr Leu Lys Lys Lys Arg Glu Glu Leu Lys Lys Lys Leu Lys Glu
545                 550                 555                 560 
Lys Ala Lys Glu Arg Arg Glu Lys Glu Met Leu Glu Arg Leu Glu Lys
                565                 570                 575     
Gln Lys Arg Tyr Glu Asp Gln Glu Leu Thr Gly Lys Asn Leu Pro Ala
            580                 585                 590         
Phe Arg Leu Val Asp Thr Pro Glu Gly Leu Pro Asn Thr Leu Phe Gly
        595                 600                 605             
Asp Val Ala Met Val Val Glu Phe Leu Ser Cys Tyr Ser Gly Leu Leu
    610                 615                 620                 
Leu Pro Asp Ala Gln Tyr Pro Ile Thr Ala Val Ser Leu Met Glu Ala
625                 630                 635                 640 
Leu Ser Ala Asp Lys Gly Gly Phe Leu Tyr Leu Asn Arg Val Leu Val
                645                 650                 655     
Ile Leu Leu Gln Thr Leu Leu Gln Asp Glu Ile Ala Glu Asp Tyr Gly
            660                 665                 670         
Glu Leu Gly Met Lys Leu Ser Glu Ile Pro Leu Thr Leu His Ser Val
        675                 680                 685             
Ser Glu Leu Val Arg Leu Cys Leu Arg Arg Ser Asp Val Gln Glu Glu
    690                 695                 700                 
Ser Glu Gly Ser Asp Thr Asp Asp Asn Lys Asp Ser Ala Ala Phe Glu
705                 710                 715                 720 
Asp Asn Glu Val Gln Asp Glu Phe Leu Glu Lys Leu Glu Thr Ser Glu
                725                 730                 735     
Phe Phe Glu Leu Thr Ser Glu Glu Lys Leu Gln Ile Leu Thr Ala Leu
            740                 745                 750         
Cys His Arg Ile Leu Met Thr Tyr Ser Val Gln Asp His Met Glu Thr
        755                 760                 765             
Arg Gln Gln Met Ser Ala Glu Leu Trp Lys Glu Arg Leu Ala Val Leu
    770                 775                 780                 
Lys Glu Glu Asn Asp Lys Lys Arg Ala Glu Lys Gln Lys Arg Lys Glu
785                 790                 795                 800 
Met Glu Ala Lys Asn Lys Glu Asn Gly Lys Val Glu Asn Gly Leu Gly
                805                 810                 815     
Lys Thr Asp Arg Lys Lys Glu Ile Val Lys Phe Glu Pro Gln Val Asp
            820                 825                 830         
Thr Glu Ala Glu Asp Met Ile Ser Ala Val Lys Ser Arg Arg Leu Leu
        835                 840                 845             
Ala Ile Gln Ala Lys Lys Glu Arg Glu Ile Gln Glu Arg Glu Met Lys
    850                 855                 860                 
Val Lys Leu Glu Arg Gln Ala Glu Glu Glu Arg Ile Arg Lys His Lys
865                 870                 875                 880 
Ala Ala Ala Glu Lys Ala Phe Gln Glu Gly Ile Ala Lys Ala Lys Leu
                885                 890                 895     
Val Met Arg Arg Thr Pro Ile Gly Thr Asp Arg Asn His Asn Arg Tyr
            900                 905                 910         
Trp Leu Phe Ser Asp Glu Val Pro Gly Leu Phe Ile Glu Lys Gly Trp
        915                 920                 925             
Val His Asp Ser Ile Asp Tyr Arg Phe Asn His His Cys Lys Asp His
    930                 935                 940                 
Thr Val Ser Gly Asp Glu Asp Tyr Cys Pro Arg Ser Lys Lys Ala Asn
945                 950                 955                 960 
Leu Gly Lys Asn Ala Ser Met Asn Thr Gln His Gly Thr Ala Thr Glu
                965                 970                 975     
Val Ala Val Glu Thr Thr Thr Pro Lys Gln Gly Gln Asn Leu Trp Phe
            980                 985                 990         
Leu Cys Asp Ser Gln Lys Glu Leu Asp Glu Leu Leu Asn Cys Leu His
        995                 1000                1005            
Pro Gln Gly Ile Arg Glu Ser Gln Leu Lys Glu Arg Leu Glu Lys Arg
    1010                1015                1020                
Tyr Gln Asp Ile Ile His Ser Ile His Leu Ala Arg Lys Pro Asn Leu
1025                1030                1035                1040
Gly Leu Lys Ser Cys Asp Gly Asn Gln Glu Leu Leu Asn Phe Leu Arg
                1045                1050                1055    
Ser Asp Leu Ile Glu Val Ala Thr Arg Leu Gln Lys Gly Gly Leu Gly
            1060                1065                1070        
Tyr Val Glu Glu Thr Ser Glu Phe Glu Ala Arg Val Ile Ser Leu Glu
        1075                1080                1085            
Lys Leu Lys Asp Phe Gly Glu Cys Val Ile Ala Leu Gln Ala Ser Val
    1090                1095                1100                
Ile Lys Lys Phe Leu Gln Gly Phe Met Ala Pro Lys Gln Lys Arg Arg
1105                1110                1115                1120
Lys Leu Gln Ser Glu Asp Ser Ala Lys Thr Glu Glu Val Asp Glu Glu
                1125                1130                1135    
Lys Lys Met Val Glu Glu Ala Lys Val Ala Ser Ala Leu Glu Lys Trp
            1140                1145                1150        
Lys Thr Ala Ile Arg Glu Ala Gln Thr Phe Ser Arg Met His Val Leu
        1155                1160                1165            
Leu Gly Met Leu Asp Ala Cys Ile Lys Trp Asp Met Ser Ala Glu Asn
    1170                1175                1180                
Ala Arg Cys Lys Val Cys Arg Lys Lys Gly Glu Asp Asp Lys Leu Ile
1185                1190                1195                1200
Leu Cys Asp Glu Cys Asn Lys Ala Phe His Leu Phe Cys Leu Arg Pro
                1205                1210                1215    
Ala Leu Tyr Glu Val Pro Asp Gly Glu Trp Gln Cys Pro Ala Cys Gln
            1220                1225                1230        
Pro Ala Thr Ala Arg Arg Asn Ser Arg Gly Arg Asn Tyr Thr Glu Glu
        1235                1240                1245            
Ser Ala Ser Glu Asp Ser Glu Asp Asp Glu Ser Asp Glu Glu Glu Glu
    1250                1255                1260                
Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Tyr Glu Val Ala Gly Leu
1265                1270                1275                1280
Arg Leu Arg Pro Arg Lys Thr Ile Arg Gly Lys His Ser Val Ile Pro
                1285                1290                1295    
Pro Ala Ala Arg Ser Gly Arg Arg Pro Gly Lys Lys Pro His Ser Thr
            1300                1305                1310        
Arg Arg Ser Gln Pro Lys Ala Pro Pro Val Asp Asp Ala Glu Val Asp
        1315                1320                1325            
Glu Leu Val Leu Gln Thr Lys Arg Ser Ser Arg Arg Gln Ser Leu Glu
    1330                1335                1340                
Leu Gln Lys Cys Glu Glu Ile Leu His Lys Ile Val Lys Tyr Arg Phe
1345                1350                1355                1360
Ser Trp Pro Phe Arg Glu Pro Val Thr Arg Asp Glu Ala Glu Asp Tyr
                1365                1370                1375    
Tyr Asp Val Ile Thr His Pro Met Asp Phe Gln Thr Val Gln Asn Lys
            1380                1385                1390        
Cys Ser Cys Gly Ser Tyr Arg Ser Val Gln Glu Phe Leu Thr Asp Met
        1395                1400                1405            
Lys Gln Val Phe Thr Asn Ala Glu Val Tyr Asn Cys Arg Gly Ser His
    1410                1415                1420                
Val Leu Ser Cys Met Val Lys Thr Glu Gln Cys Leu Val Ala Leu Leu
1425                1430                1435                1440
His Lys His Leu Pro Gly His Pro Tyr Val Arg Arg Lys Arg Lys Lys
                1445                1450                1455    
Phe Pro Asp Arg Leu Ala Glu Asp Glu Gly Asp Ser Glu Pro Glu Ala
            1460                1465                1470        
Val Gly Gln Ser Arg Gly Arg Arg Gln Lys Lys
        1475                1480            


<210> 6039
<211> 165
<212> PRT
<213> Homo sapiens

<400> 6039
Met Val Thr Ser Arg Glu Arg Gly Thr Thr Arg Leu Thr Lys Ala Leu
 1               5                  10                  15      
Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr Cys Gln Arg Ala Tyr Cys
            20                  25                  30          
His Ile Leu Leu Gly Asn Tyr Cys Val Ala Val Ala Asp Ala Lys Lys
        35                  40                  45              
Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr Ala Met Leu Arg Lys Gly
    50                  55                  60                  
Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala Ala Ala Leu Glu Thr Phe
65                  70                  75                  80  
Thr Glu Gly Gln Lys Leu Asp Ile Glu Thr Gly Phe His Arg Val Gly
                85                  90                  95      
Gln Ala Gly Leu Gln Leu Leu Thr Ser Ser Asp Pro Pro Ala Leu Asp
            100                 105                 110         
Ser Gln Ser Ala Gly Ile Thr Gly Ala Asp Ala Asn Phe Ser Val Trp
        115                 120                 125             
Ile Lys Arg Cys Gln Glu Ala Gln Asn Gly Ser Glu Ser Glu Val Trp
    130                 135                 140                 
Thr His Gln Ser Lys Ile Lys Tyr Asp Trp Tyr Gln Thr Glu Ser Gln
145                 150                 155                 160 
Val Val Ile Thr Ile
                165 


<210> 6040
<211> 949
<212> PRT
<213> Homo sapiens

<400> 6040
Met Ala Ser Asn His Pro Ala Phe Ser Phe His Gln Lys Gln Val Leu
 1               5                  10                  15      
Arg Gln Glu Leu Thr Gln Ile Gln Ser Ser Leu Asn Gly Gly Gly Gly
            20                  25                  30          
His Gly Gly Lys Gly Ala Pro Gly Pro Gly Gly Ala Leu Pro Thr Cys
        35                  40                  45              
Pro Ala Cys His Lys Ile Thr Pro Arg Thr Glu Ala Pro Val Ser Ser
    50                  55                  60                  
Val Ser Asn Ser Leu Glu Asn Ala Leu His Thr Ser Ala His Ser Thr
65                  70                  75                  80  
Glu Glu Ser Leu Pro Lys Arg Pro Leu Gly Lys His Ser Lys Val Ser
                85                  90                  95      
Val Glu Lys Ile Asp Leu Lys Gly Leu Ser His Thr Lys Asn Asp Arg
            100                 105                 110         
Asn Val Glu Cys Ser Phe Glu Val Leu Trp Ser Asp Ser Ser Ile Thr
        115                 120                 125             
Ser Val Thr Lys Ser Ser Ser Glu Val Thr Glu Phe Ile Ser Lys Leu
    130                 135                 140                 
Cys Gln Leu Tyr Pro Glu Glu Asn Leu Glu Lys Leu Ile Pro Cys Leu
145                 150                 155                 160 
Ala Gly Pro Asp Ala Phe Tyr Val Glu Arg Asn His Val Asp Leu Asp
                165                 170                 175     
Ser Gly Leu Arg Tyr Leu Ala Ser Leu Pro Ser His Val Leu Lys Asn
            180                 185                 190         
Asp His Val Arg Arg Phe Leu Ser Thr Ser Ser Pro Pro Gln Gln Leu
        195                 200                 205             
Gln Ser Pro Ser Pro Gly Asn Pro Ser Leu Ser Lys Val Gly Thr Val
    210                 215                 220                 
Met Gly Val Ser Gly Arg Pro Val Cys Gly Val Ala Gly Ile Pro Ser
225                 230                 235                 240 
Ser Gln Ser Gly Ala Gln His His Gly Gln His Pro Ala Gly Ser Ala
                245                 250                 255     
Ala Pro Leu Pro His Cys Ser His Ala Gly Ser Ala Gly Ser Ala Leu
            260                 265                 270         
Ala Tyr Arg Thr Gln Met Asp Thr Ser Pro Ala Ile Leu Met Pro Ser
        275                 280                 285             
Ser Leu Gln Thr Pro Gln Thr Gln Glu Gln Asn Gly Ile Leu Asp Trp
    290                 295                 300                 
Leu Arg Lys Leu Arg Leu His Lys Tyr Tyr Pro Val Phe Lys Gln Leu
305                 310                 315                 320 
Ser Met Glu Lys Phe Leu Ser Leu Thr Glu Glu Asp Leu Asn Lys Phe
                325                 330                 335     
Glu Ser Leu Thr Met Gly Ala Lys Lys Lys Leu Lys Thr Gln Leu Glu
            340                 345                 350         
Leu Glu Lys Glu Lys Ser Glu Arg Arg Cys Leu Asn Pro Ser Ala Pro
        355                 360                 365             
Pro Leu Val Thr Ser Ser Gly Val Ala Arg Val Pro Pro Thr Ser His
    370                 375                 380                 
Val Gly Pro Val Gln Ser Gly Arg Gly Ser His Ala Ala Glu Leu Arg
385                 390                 395                 400 
Val Glu Val Glu Gln Pro His His Gln Leu Pro Arg Glu Gly Ser Ser
                405                 410                 415     
Ser Glu Tyr Ser Ser Ser Ser Ser Ser Pro Met Gly Val Gln Ala Arg
            420                 425                 430         
Glu Glu Ser Ser Asp Ser Ala Glu Glu Asn Asp Arg Arg Val Glu Ile
        435                 440                 445             
His Leu Glu Ser Ser Asp Lys Glu Lys Pro Val Met Leu Leu Asn His
    450                 455                 460                 
Phe Thr Ser Ser Ser Ala Arg Pro Thr Ala Gln Val Leu Pro Val Gln
465                 470                 475                 480 
Asn Glu Ala Ser Ser Asn Pro Ser Gly His His Pro Leu Pro Pro Gln
                485                 490                 495     
Met Leu Ser Ala Ala Ser His Ile Thr Pro Ile Arg Met Leu Asn Ser
            500                 505                 510         
Val His Lys Pro Glu Arg Gly Ser Ala Asp Met Lys Leu Leu Ser Ser
        515                 520                 525             
Ser Val His Ser Leu Leu Ser Leu Glu Glu Arg Asn Lys Gly Ser Gly
    530                 535                 540                 
Pro Arg Ser Ser Met Lys Val Asp Lys Ser Phe Gly Ser Ala Met Met
545                 550                 555                 560 
Asp Val Leu Pro Ala Ser Ala Pro His Gln Pro Val Gln Val Leu Ser
                565                 570                 575     
Gly Leu Ser Glu Ser Ser Ser Met Ser Pro Thr Val Ser Phe Gly Pro
            580                 585                 590         
Arg Thr Lys Val Val His Ala Ser Thr Leu Asp Arg Val Leu Lys Thr
        595                 600                 605             
Ala Gln Gln Pro Ala Leu Val Val Glu Thr Ser Thr Ala Ala Thr Gly
    610                 615                 620                 
Thr Pro Ser Thr Val Leu His Ala Ala Arg Pro Pro Ile Lys Leu Leu
625                 630                 635                 640 
Leu Ser Ser Ser Val Pro Ala Asp Ser Ala Ile Ser Gly Gln Thr Ser
                645                 650                 655     
Cys Pro Asn Asn Val Gln Ile Ser Val Pro Pro Ala Ile Ile Asn Pro
            660                 665                 670         
Arg Thr Ala Leu Tyr Thr Ala Asn Thr Lys Val Ala Phe Ser Ala Met
        675                 680                 685             
Ser Ser Met Pro Val Gly Pro Leu Gln Gly Gly Phe Cys Ala Asn Ser
    690                 695                 700                 
Asn Thr Ala Ser Pro Ser Ser His Pro Ser Thr Ser Phe Ala Asn Met
705                 710                 715                 720 
Ala Thr Leu Pro Ser Cys Pro Ala Pro Ser Ser Ser Pro Ala Leu Ser
                725                 730                 735     
Ser Val Pro Glu Ser Ser Phe Tyr Ser Ser Ser Gly Gly Gly Gly Ser
            740                 745                 750         
Thr Gly Asn Ile Pro Ala Ser Asn Pro Asn His His His His His His
        755                 760                 765             
His Gln Gln Pro Pro Ala Pro Pro Gln Pro Ala Pro Pro Pro Pro Gly
    770                 775                 780                 
Cys Ile Val Cys Thr Ser Cys Gly Cys Ser Gly Ser Cys Gly Ser Ser
785                 790                 795                 800 
Gly Leu Thr Val Ser Tyr Ala Asn Tyr Phe Gln His Pro Phe Ser Gly
                805                 810                 815     
Pro Ser Val Phe Thr Phe Pro Phe Leu Pro Phe Ser Pro Met Cys Ser
            820                 825                 830         
Ser Gly Tyr Val Ser Ala Gln Gln Tyr Gly Gly Gly Ser Thr Phe Pro
        835                 840                 845             
Val Val His Ala Pro Tyr Ser Ser Ser Gly Thr Pro Asp Pro Val Leu
    850                 855                 860                 
Ser Gly Gln Ser Thr Phe Ala Val Pro Pro Met Gln Asn Phe Met Ala
865                 870                 875                 880 
Gly Thr Ala Gly Val Tyr Gln Thr Gln Gly Leu Val Gly Ser Ser Asn
                885                 890                 895     
Gly Ser Ser His Lys Lys Ser Gly Asn Leu Ser Cys Tyr Asn Cys Gly
            900                 905                 910         
Ala Thr Gly His Arg Ala Gln Asp Cys Lys Gln Pro Ser Met Asp Phe
        915                 920                 925             
Asn Arg Pro Gly Thr Phe Arg Leu Lys Tyr Ala Pro Pro Ala Glu Ser
    930                 935                 940                 
Leu Asp Ser Thr Asp
945                 


<210> 6041
<211> 1638
<212> PRT
<213> Homo sapiens

<400> 6041
Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly
 1               5                  10                  15      
Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr
            20                  25                  30          
Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr
        35                  40                  45              
Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly
    50                  55                  60                  
Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly
65                  70                  75                  80  
Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser
                85                  90                  95      
Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn
            100                 105                 110         
Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly
        115                 120                 125             
Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser
    130                 135                 140                 
Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr
145                 150                 155                 160 
Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala
                165                 170                 175     
Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met
            180                 185                 190         
Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr
        195                 200                 205             
Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr
    210                 215                 220                 
Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu
225                 230                 235                 240 
Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys
                245                 250                 255     
Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly
            260                 265                 270         
Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro
        275                 280                 285             
Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn
    290                 295                 300                 
Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly
305                 310                 315                 320 
Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn
                325                 330                 335     
Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln
            340                 345                 350         
Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn
        355                 360                 365             
Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly
    370                 375                 380                 
Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn
385                 390                 395                 400 
Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu
                405                 410                 415     
Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe
            420                 425                 430         
Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe
        435                 440                 445             
Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala
    450                 455                 460                 
Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln
465                 470                 475                 480 
Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe
                485                 490                 495     
Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys
            500                 505                 510         
Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr
        515                 520                 525             
Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg
    530                 535                 540                 
Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp
545                 550                 555                 560 
Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro
                565                 570                 575     
Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn
            580                 585                 590         
Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser
        595                 600                 605             
Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val
    610                 615                 620                 
Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His
625                 630                 635                 640 
Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser
                645                 650                 655     
Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val
            660                 665                 670         
Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser
        675                 680                 685             
Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu
    690                 695                 700                 
Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr
705                 710                 715                 720 
Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile
                725                 730                 735     
Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg
            740                 745                 750         
Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn
        755                 760                 765             
Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val
    770                 775                 780                 
Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg
785                 790                 795                 800 
Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser
                805                 810                 815     
Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu
            820                 825                 830         
Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu
        835                 840                 845             
Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser
    850                 855                 860                 
Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser
865                 870                 875                 880 
Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser
                885                 890                 895     
Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro
            900                 905                 910         
Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu
        915                 920                 925             
Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr
    930                 935                 940                 
Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser
945                 950                 955                 960 
Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile
                965                 970                 975     
Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu
            980                 985                 990         
Asp Gln Arg Phe Ser Arg Leu Pro Ser Lys Ala Asp Thr Ser Gln Glu
        995                 1000                1005            
Ile Cys Ser Pro Arg Leu Pro Ile Ser Ala Ser His Ser Ser Lys Thr
    1010                1015                1020                
Arg Ser Leu Val Gly Gly Leu Leu Gln Ser Lys Phe Thr Ser Gly Ala
1025                1030                1035                1040
Phe Leu Ser Pro Ser Val Ser Val Gln Glu Cys Arg Thr Pro Arg Ala
                1045                1050                1055    
Ala Ser Leu Met Asn Ile Pro Ser Thr Ser Ser Trp Ser Val Pro Pro
            1060                1065                1070        
Pro Leu Thr Ser Val Phe Thr Met Pro Ser Pro Ala Pro Glu Val Pro
        1075                1080                1085            
Leu Lys Thr Val Gly Thr Arg Arg Gln Leu Gly Leu Val Pro Arg Glu
    1090                1095                1100                
Lys Ser Val Thr Tyr Gly Lys Gly Lys Leu Leu Met Asp Met Ala Leu
1105                1110                1115                1120
Phe Met Gly Arg Ser Phe Arg Val Gly Trp Gly Pro Asn Trp Thr Leu
                1125                1130                1135    
Ala Asn Ser Gly Glu Gln Leu Asn Gly Ser His Glu Leu Glu Asn His
            1140                1145                1150        
Gln Ile Ala Asp Ser Met Glu Phe Gly Phe Leu Pro Asn Pro Val Ala
        1155                1160                1165            
Val Lys Pro Leu Thr Glu Ser Pro Phe Lys Val His Leu Glu Lys Leu
    1170                1175                1180                
Ser Leu Arg Gln Arg Lys Pro Asp Glu Asp Met Lys Leu Tyr Gln Thr
1185                1190                1195                1200
Pro Leu Glu Leu Lys Leu Lys His Ser Thr Val His Val Asp Glu Leu
                1205                1210                1215    
Cys Pro Leu Ile Val Pro Asn Leu Gly Val Ala Val Ile His Asp Tyr
            1220                1225                1230        
Ala Asp Trp Val Lys Glu Ala Ser Gly Asp Leu Pro Glu Ala Gln Ile
        1235                1240                1245            
Val Lys His Trp Ser Leu Thr Trp Thr Leu Cys Glu Ala Leu Trp Gly
    1250                1255                1260                
His Leu Lys Glu Leu Asp Ser Gln Leu Asn Glu Pro Arg Glu Tyr Ile
1265                1270                1275                1280
Gln Ile Leu Glu Arg Arg Arg Ala Phe Ser Arg Trp Leu Ser Cys Thr
                1285                1290                1295    
Ala Thr Pro Gln Ile Glu Glu Glu Val Ser Leu Thr Gln Lys Asn Ser
            1300                1305                1310        
Pro Val Glu Ala Val Phe Ser Tyr Leu Thr Gly Lys Arg Ile Ser Glu
        1315                1320                1325            
Ala Cys Ser Leu Ala Gln Gln Ser Gly Asp His Arg Leu Ala Leu Leu
    1330                1335                1340                
Leu Ser Gln Phe Val Gly Ser Gln Ser Val Arg Glu Leu Leu Thr Met
1345                1350                1355                1360
Gln Leu Val Asp Trp His Gln Leu Gln Ala Asp Ser Phe Ile Gln Asp
                1365                1370                1375    
Glu Arg Leu Arg Ile Phe Ala Leu Leu Ala Gly Lys Pro Val Trp Gln
            1380                1385                1390        
Leu Ser Glu Lys Lys Gln Ile Asn Val Cys Ser Gln Leu Asp Trp Lys
        1395                1400                1405            
Arg Ser Leu Ala Ile His Leu Trp Tyr Leu Leu Pro Pro Thr Ala Ser
    1410                1415                1420                
Ile Ser Arg Ala Leu Ser Met Tyr Glu Glu Ala Phe Gln Asn Thr Ser
1425                1430                1435                1440
Asp Ser Asp Arg Tyr Ala Cys Ser Pro Leu Pro Ser Tyr Leu Glu Gly
                1445                1450                1455    
Ser Gly Cys Val Ile Ala Glu Glu Gln Asn Ser Gln Thr Pro Leu Arg
            1460                1465                1470        
Asp Val Cys Phe His Leu Leu Lys Leu Tyr Ser Asp Ser Ile Arg Glu
        1475                1480                1485            
Lys Ala Val Arg Glu Leu Leu Thr Arg His Cys Gln Leu Leu Glu Thr
    1490                1495                1500                
Pro Glu Ser Trp Ala Lys Glu Thr Phe Leu Thr Gln Lys Leu Arg Val
1505                1510                1515                1520
Pro Ala Lys Trp Ile His Glu Ala Lys Ala Val Arg Ala His Met Glu
                1525                1530                1535    
Ser Asp Lys His Leu Glu Ala Leu Cys Leu Phe Lys Ala Glu His Trp
            1540                1545                1550        
Asn Arg Cys His Lys Leu Ile Ile Arg His Leu Ala Ser Asp Ala Ile
        1555                1560                1565            
Ile Asn Glu Asn Tyr Asp Tyr Leu Lys Gly Phe Leu Glu Asp Leu Ala
    1570                1575                1580                
Pro Pro Glu Arg Ser Ser Leu Ile Gln Asp Trp Glu Thr Ser Gly Leu
1585                1590                1595                1600
Val Tyr Leu Asp Tyr Ile Arg Val Ile Glu Met Leu Arg His Ile Gln
                1605                1610                1615    
Gln Val Glu His Phe Asn Asp Ser Asn Ile Val Gln Val Met Thr Trp
            1620                1625                1630        
Ser Ser Tyr Thr Ser Lys
        1635            


<210> 6042
<211> 1712
<212> PRT
<213> Homo sapiens

<400> 6042
Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly
 1               5                  10                  15      
Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr
            20                  25                  30          
Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr
        35                  40                  45              
Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly
    50                  55                  60                  
Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly
65                  70                  75                  80  
Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser
                85                  90                  95      
Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn
            100                 105                 110         
Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly
        115                 120                 125             
Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser
    130                 135                 140                 
Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr
145                 150                 155                 160 
Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala
                165                 170                 175     
Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met
            180                 185                 190         
Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr
        195                 200                 205             
Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr
    210                 215                 220                 
Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu
225                 230                 235                 240 
Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys
                245                 250                 255     
Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly
            260                 265                 270         
Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro
        275                 280                 285             
Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn
    290                 295                 300                 
Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly
305                 310                 315                 320 
Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn
                325                 330                 335     
Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln
            340                 345                 350         
Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn
        355                 360                 365             
Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly
    370                 375                 380                 
Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn
385                 390                 395                 400 
Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu
                405                 410                 415     
Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe
            420                 425                 430         
Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe
        435                 440                 445             
Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala
    450                 455                 460                 
Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln
465                 470                 475                 480 
Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe
                485                 490                 495     
Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys
            500                 505                 510         
Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr
        515                 520                 525             
Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg
    530                 535                 540                 
Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp
545                 550                 555                 560 
Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro
                565                 570                 575     
Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn
            580                 585                 590         
Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser
        595                 600                 605             
Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val
    610                 615                 620                 
Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His
625                 630                 635                 640 
Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser
                645                 650                 655     
Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val
            660                 665                 670         
Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser
        675                 680                 685             
Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu
    690                 695                 700                 
Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr
705                 710                 715                 720 
Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile
                725                 730                 735     
Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg
            740                 745                 750         
Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn
        755                 760                 765             
Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val
    770                 775                 780                 
Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg
785                 790                 795                 800 
Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser
                805                 810                 815     
Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu
            820                 825                 830         
Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu
        835                 840                 845             
Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser
    850                 855                 860                 
Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser
865                 870                 875                 880 
Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser
                885                 890                 895     
Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro
            900                 905                 910         
Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu
        915                 920                 925             
Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr
    930                 935                 940                 
Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser
945                 950                 955                 960 
Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile
                965                 970                 975     
Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu
            980                 985                 990         
Asp Gln Arg Phe Ser Arg Leu Pro Ser Lys Ala Asp Thr Ser Gln Glu
        995                 1000                1005            
Ile Cys Ser Pro Arg Leu Pro Ile Ser Ala Ser His Ser Ser Lys Thr
    1010                1015                1020                
Arg Ser Leu Val Gly Gly Leu Leu Gln Ser Lys Phe Thr Ser Gly Ala
1025                1030                1035                1040
Phe Leu Ser Pro Ser Val Ser Val Gln Glu Cys Arg Thr Pro Arg Ala
                1045                1050                1055    
Ala Ser Leu Met Asn Ile Pro Ser Thr Ser Ser Trp Ser Val Pro Pro
            1060                1065                1070        
Pro Leu Thr Ser Val Phe Thr Met Pro Ser Pro Ala Pro Glu Val Pro
        1075                1080                1085            
Leu Lys Thr Val Gly Thr Arg Arg Gln Leu Gly Leu Val Pro Arg Glu
    1090                1095                1100                
Lys Ser Val Thr Tyr Gly Lys Gly Lys Leu Leu Met Asp Met Ala Leu
1105                1110                1115                1120
Phe Met Gly Arg Ser Phe Arg Val Gly Trp Gly Pro Asn Trp Thr Leu
                1125                1130                1135    
Ala Asn Ser Gly Glu Gln Leu Asn Gly Ser His Glu Leu Glu Asn His
            1140                1145                1150        
Gln Ile Ala Asp Ser Met Glu Phe Gly Phe Leu Pro Asn Pro Val Ala
        1155                1160                1165            
Val Lys Pro Leu Thr Glu Ser Pro Phe Lys Val His Leu Glu Lys Leu
    1170                1175                1180                
Ser Leu Arg Gln Arg Lys Pro Asp Glu Asp Met Lys Leu Tyr Gln Thr
1185                1190                1195                1200
Pro Leu Glu Leu Lys Leu Lys His Ser Thr Val His Val Asp Glu Leu
                1205                1210                1215    
Cys Pro Leu Ile Val Pro Asn Leu Gly Val Ala Val Ile His Asp Tyr
            1220                1225                1230        
Ala Asp Trp Val Lys Glu Ala Ser Gly Asp Leu Pro Glu Ala Gln Ile
        1235                1240                1245            
Val Lys His Trp Ser Leu Thr Trp Thr Leu Cys Glu Ala Leu Trp Gly
    1250                1255                1260                
His Leu Lys Glu Leu Asp Ser Gln Leu Asn Glu Pro Arg Glu Tyr Ile
1265                1270                1275                1280
Gln Ile Leu Glu Arg Arg Arg Ala Phe Ser Arg Trp Leu Ser Cys Thr
                1285                1290                1295    
Ala Thr Pro Gln Ile Glu Glu Glu Val Ser Leu Thr Gln Lys Asn Ser
            1300                1305                1310        
Pro Val Glu Ala Val Phe Ser Tyr Leu Thr Gly Lys Arg Ile Ser Glu
        1315                1320                1325            
Ala Cys Ser Leu Ala Gln Gln Ser Gly Asp His Arg Leu Ala Leu Leu
    1330                1335                1340                
Leu Ser Gln Phe Val Gly Ser Gln Ser Val Arg Glu Leu Leu Thr Met
1345                1350                1355                1360
Gln Leu Val Asp Trp His Gln Leu Gln Ala Asp Ser Phe Ile Gln Asp
                1365                1370                1375    
Glu Arg Leu Arg Ile Phe Ala Leu Leu Ala Gly Lys Pro Val Trp Gln
            1380                1385                1390        
Leu Ser Glu Lys Lys Gln Ile Asn Val Cys Ser Gln Leu Asp Trp Lys
        1395                1400                1405            
Arg Ser Leu Ala Ile His Leu Trp Tyr Leu Leu Pro Pro Thr Ala Ser
    1410                1415                1420                
Ile Ser Arg Ala Leu Ser Met Tyr Glu Glu Ala Phe Gln Asn Thr Ser
1425                1430                1435                1440
Asp Ser Asp Arg Tyr Ala Cys Ser Pro Leu Pro Ser Tyr Leu Glu Gly
                1445                1450                1455    
Ser Gly Cys Val Ile Ala Glu Glu Gln Asn Ser Gln Thr Pro Leu Arg
            1460                1465                1470        
Asp Val Cys Phe His Leu Leu Lys Leu Tyr Ser Asp Arg His Tyr Asp
        1475                1480                1485            
Leu Asn Gln Leu Leu Glu Pro Arg Ser Ile Thr Ala Asp Pro Leu Asp
    1490                1495                1500                
Tyr Arg Leu Ser Trp His Leu Trp Glu Val Leu Arg Ala Leu Asn Tyr
1505                1510                1515                1520
Thr His Leu Ser Ala Gln Cys Glu Gly Val Leu Gln Ala Ser Tyr Ala
                1525                1530                1535    
Gly Gln Leu Glu Ser Glu Gly Leu Trp Glu Trp Ala Ile Phe Val Leu
            1540                1545                1550        
Leu His Ile Asp Asn Ser Gly Ile Arg Glu Lys Ala Val Arg Glu Leu
        1555                1560                1565            
Leu Thr Arg His Cys Gln Leu Leu Glu Thr Pro Glu Ser Trp Ala Lys
    1570                1575                1580                
Glu Thr Phe Leu Thr Gln Lys Leu Arg Val Pro Ala Lys Trp Ile His
1585                1590                1595                1600
Glu Ala Lys Ala Val Arg Ala His Met Glu Ser Asp Lys His Leu Glu
                1605                1610                1615    
Ala Leu Cys Leu Phe Lys Ala Glu His Trp Asn Arg Cys His Lys Leu
            1620                1625                1630        
Ile Ile Arg His Leu Ala Ser Asp Ala Ile Ile Asn Glu Asn Tyr Asp
        1635                1640                1645            
Tyr Leu Lys Gly Phe Leu Glu Asp Leu Ala Pro Pro Glu Arg Ser Ser
    1650                1655                1660                
Leu Ile Gln Asp Trp Glu Thr Ser Gly Leu Val Tyr Leu Asp Tyr Ile
1665                1670                1675                1680
Arg Val Ile Glu Met Leu Arg His Ile Gln Gln Val Glu His Phe Asn
                1685                1690                1695    
Asp Ser Asn Ile Val Gln Val Met Thr Trp Ser Ser Tyr Thr Ser Lys
            1700                1705                1710        


<210> 6043
<211> 937
<212> PRT
<213> Homo sapiens

<400> 6043
Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly
 1               5                  10                  15      
Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr
            20                  25                  30          
Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr
        35                  40                  45              
Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly
    50                  55                  60                  
Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly
65                  70                  75                  80  
Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser
                85                  90                  95      
Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn
            100                 105                 110         
Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly
        115                 120                 125             
Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser
    130                 135                 140                 
Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr
145                 150                 155                 160 
Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala
                165                 170                 175     
Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met
            180                 185                 190         
Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr
        195                 200                 205             
Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr
    210                 215                 220                 
Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu
225                 230                 235                 240 
Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys
                245                 250                 255     
Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly
            260                 265                 270         
Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro
        275                 280                 285             
Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn
    290                 295                 300                 
Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly
305                 310                 315                 320 
Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn
                325                 330                 335     
Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln
            340                 345                 350         
Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn
        355                 360                 365             
Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly
    370                 375                 380                 
Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly
385                 390                 395                 400 
Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Thr Ser Gly
                405                 410                 415     
Asn Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly
            420                 425                 430         
Leu Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu
        435                 440                 445             
Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala
    450                 455                 460                 
Phe Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly
465                 470                 475                 480 
Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala
                485                 490                 495     
Gln Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro
            500                 505                 510         
Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys
        515                 520                 525             
Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu
    530                 535                 540                 
Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val
545                 550                 555                 560 
Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe
                565                 570                 575     
Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met
            580                 585                 590         
Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser
        595                 600                 605             
Asn Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro
    610                 615                 620                 
Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro
625                 630                 635                 640 
Val Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser
                645                 650                 655     
His Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu
            660                 665                 670         
Ser Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile
        675                 680                 685             
Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser
    690                 695                 700                 
Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu
705                 710                 715                 720 
Glu Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu
                725                 730                 735     
Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys
            740                 745                 750         
Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly
        755                 760                 765             
Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr
    770                 775                 780                 
Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val
785                 790                 795                 800 
Val Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn
                805                 810                 815     
Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr
            820                 825                 830         
Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr
        835                 840                 845             
Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys
    850                 855                 860                 
Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe
865                 870                 875                 880 
Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro
                885                 890                 895     
Ser Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala
            900                 905                 910         
Ser Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro
        915                 920                 925             
Pro Pro Gln Val Glu Lys Lys Gly Gln
    930                 935         


<210> 6044
<211> 1729
<212> PRT
<213> Homo sapiens

<400> 6044
Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly
 1               5                  10                  15      
Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr
            20                  25                  30          
Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr
        35                  40                  45              
Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly
    50                  55                  60                  
Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly
65                  70                  75                  80  
Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser
                85                  90                  95      
Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn
            100                 105                 110         
Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly
        115                 120                 125             
Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser
    130                 135                 140                 
Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr
145                 150                 155                 160 
Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala
                165                 170                 175     
Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met
            180                 185                 190         
Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr
        195                 200                 205             
Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr
    210                 215                 220                 
Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu
225                 230                 235                 240 
Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys
                245                 250                 255     
Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly
            260                 265                 270         
Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro
        275                 280                 285             
Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn
    290                 295                 300                 
Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly
305                 310                 315                 320 
Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn
                325                 330                 335     
Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln
            340                 345                 350         
Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn
        355                 360                 365             
Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly
    370                 375                 380                 
Thr Thr Ser Gly Gly Leu Phe Gly Asn Lys Pro Thr Leu Thr Leu Gly
385                 390                 395                 400 
Thr Asn Thr Asn Thr Ser Asn Phe Gly Phe Gly Thr Asn Thr Ser Gly
                405                 410                 415     
Asn Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly
            420                 425                 430         
Leu Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu
        435                 440                 445             
Phe Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala
    450                 455                 460                 
Phe Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly
465                 470                 475                 480 
Ala Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala
                485                 490                 495     
Gln Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro
            500                 505                 510         
Phe Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys
        515                 520                 525             
Lys Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu
    530                 535                 540                 
Thr Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val
545                 550                 555                 560 
Arg Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe
                565                 570                 575     
Asp Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met
            580                 585                 590         
Pro Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser
        595                 600                 605             
Asn Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro
    610                 615                 620                 
Ser Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro
625                 630                 635                 640 
Val Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser
                645                 650                 655     
His Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu
            660                 665                 670         
Ser Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile
        675                 680                 685             
Val Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser
    690                 695                 700                 
Ser Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu
705                 710                 715                 720 
Glu Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu
                725                 730                 735     
Thr Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys
            740                 745                 750         
Ile Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly
        755                 760                 765             
Arg Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr
    770                 775                 780                 
Asn Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val
785                 790                 795                 800 
Val Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn
                805                 810                 815     
Arg Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr
            820                 825                 830         
Ser Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr
        835                 840                 845             
Glu Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys
    850                 855                 860                 
Glu Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe
865                 870                 875                 880 
Ser Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro
                885                 890                 895     
Ser Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala
            900                 905                 910         
Ser Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro
        915                 920                 925             
Pro Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val
    930                 935                 940                 
Glu Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp
945                 950                 955                 960 
Thr Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala
                965                 970                 975     
Ser Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln
            980                 985                 990         
Ile Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala
        995                 1000                1005            
Leu Asp Gln Arg Phe Ser Arg Leu Pro Ser Lys Ala Asp Thr Ser Gln
    1010                1015                1020                
Glu Ile Cys Ser Pro Arg Leu Pro Ile Ser Ala Ser His Ser Ser Lys
1025                1030                1035                1040
Thr Arg Ser Leu Val Gly Gly Leu Leu Gln Ser Lys Phe Thr Ser Gly
                1045                1050                1055    
Ala Phe Leu Ser Pro Ser Val Ser Val Gln Glu Cys Arg Thr Pro Arg
            1060                1065                1070        
Ala Ala Ser Leu Met Asn Ile Pro Ser Thr Ser Ser Trp Ser Val Pro
        1075                1080                1085            
Pro Pro Leu Thr Ser Val Phe Thr Met Pro Ser Pro Ala Pro Glu Val
    1090                1095                1100                
Pro Leu Lys Thr Val Gly Thr Arg Arg Gln Leu Gly Leu Val Pro Arg
1105                1110                1115                1120
Glu Lys Ser Val Thr Tyr Gly Lys Gly Lys Leu Leu Met Asp Met Ala
                1125                1130                1135    
Leu Phe Met Gly Arg Ser Phe Arg Val Gly Trp Gly Pro Asn Trp Thr
            1140                1145                1150        
Leu Ala Asn Ser Gly Glu Gln Leu Asn Gly Ser His Glu Leu Glu Asn
        1155                1160                1165            
His Gln Ile Ala Asp Ser Met Glu Phe Gly Phe Leu Pro Asn Pro Val
    1170                1175                1180                
Ala Val Lys Pro Leu Thr Glu Ser Pro Phe Lys Val His Leu Glu Lys
1185                1190                1195                1200
Leu Ser Leu Arg Gln Arg Lys Pro Asp Glu Asp Met Lys Leu Tyr Gln
                1205                1210                1215    
Thr Pro Leu Glu Leu Lys Leu Lys His Ser Thr Val His Val Asp Glu
            1220                1225                1230        
Leu Cys Pro Leu Ile Val Pro Asn Leu Gly Val Ala Val Ile His Asp
        1235                1240                1245            
Tyr Ala Asp Trp Val Lys Glu Ala Ser Gly Asp Leu Pro Glu Ala Gln
    1250                1255                1260                
Ile Val Lys His Trp Ser Leu Thr Trp Thr Leu Cys Glu Ala Leu Trp
1265                1270                1275                1280
Gly His Leu Lys Glu Leu Asp Ser Gln Leu Asn Glu Pro Arg Glu Tyr
                1285                1290                1295    
Ile Gln Ile Leu Glu Arg Arg Arg Ala Phe Ser Arg Trp Leu Ser Cys
            1300                1305                1310        
Thr Ala Thr Pro Gln Ile Glu Glu Glu Val Ser Leu Thr Gln Lys Asn
        1315                1320                1325            
Ser Pro Val Glu Ala Val Phe Ser Tyr Leu Thr Gly Lys Arg Ile Ser
    1330                1335                1340                
Glu Ala Cys Ser Leu Ala Gln Gln Ser Gly Asp His Arg Leu Ala Leu
1345                1350                1355                1360
Leu Leu Ser Gln Phe Val Gly Ser Gln Ser Val Arg Glu Leu Leu Thr
                1365                1370                1375    
Met Gln Leu Val Asp Trp His Gln Leu Gln Ala Asp Ser Phe Ile Gln
            1380                1385                1390        
Asp Glu Arg Leu Arg Ile Phe Ala Leu Leu Ala Gly Lys Pro Val Trp
        1395                1400                1405            
Gln Leu Ser Glu Lys Lys Gln Ile Asn Val Cys Ser Gln Leu Asp Trp
    1410                1415                1420                
Lys Arg Ser Leu Ala Ile His Leu Trp Tyr Leu Leu Pro Pro Thr Ala
1425                1430                1435                1440
Ser Ile Ser Arg Ala Leu Ser Met Tyr Glu Glu Ala Phe Gln Asn Thr
                1445                1450                1455    
Ser Asp Ser Asp Arg Tyr Ala Cys Ser Pro Leu Pro Ser Tyr Leu Glu
            1460                1465                1470        
Gly Ser Gly Cys Val Ile Ala Glu Glu Gln Asn Ser Gln Thr Pro Leu
        1475                1480                1485            
Arg Asp Val Cys Phe His Leu Leu Lys Leu Tyr Ser Asp Arg His Tyr
    1490                1495                1500                
Asp Leu Asn Gln Leu Leu Glu Pro Arg Ser Ile Thr Ala Asp Pro Leu
1505                1510                1515                1520
Asp Tyr Arg Leu Ser Trp His Leu Trp Glu Val Leu Arg Ala Leu Asn
                1525                1530                1535    
Tyr Thr His Leu Ser Ala Gln Cys Glu Gly Val Leu Gln Ala Ser Tyr
            1540                1545                1550        
Ala Gly Gln Leu Glu Ser Glu Gly Leu Trp Glu Trp Ala Ile Phe Val
        1555                1560                1565            
Leu Leu His Ile Asp Asn Ser Gly Ile Arg Glu Lys Ala Val Arg Glu
    1570                1575                1580                
Leu Leu Thr Arg His Cys Gln Leu Leu Glu Thr Pro Glu Ser Trp Ala
1585                1590                1595                1600
Lys Glu Thr Phe Leu Thr Gln Lys Leu Arg Val Pro Ala Lys Trp Ile
                1605                1610                1615    
His Glu Ala Lys Ala Val Arg Ala His Met Glu Ser Asp Lys His Leu
            1620                1625                1630        
Glu Ala Leu Cys Leu Phe Lys Ala Glu His Trp Asn Arg Cys His Lys
        1635                1640                1645            
Leu Ile Ile Arg His Leu Ala Ser Asp Ala Ile Ile Asn Glu Asn Tyr
    1650                1655                1660                
Asp Tyr Leu Lys Gly Phe Leu Glu Asp Leu Ala Pro Pro Glu Arg Ser
1665                1670                1675                1680
Ser Leu Ile Gln Asp Trp Glu Thr Ser Gly Leu Val Tyr Leu Asp Tyr
                1685                1690                1695    
Ile Arg Val Ile Glu Met Leu Arg His Ile Gln Gln Val Glu His Phe
            1700                1705                1710        
Asn Asp Ser Asn Ile Val Gln Val Met Thr Trp Ser Ser Tyr Thr Ser
        1715                1720                1725            
Lys
    


<210> 6045
<211> 920
<212> PRT
<213> Homo sapiens

<400> 6045
Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly
 1               5                  10                  15      
Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr
            20                  25                  30          
Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr
        35                  40                  45              
Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly
    50                  55                  60                  
Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly
65                  70                  75                  80  
Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser
                85                  90                  95      
Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn
            100                 105                 110         
Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly
        115                 120                 125             
Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser
    130                 135                 140                 
Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr
145                 150                 155                 160 
Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala
                165                 170                 175     
Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met
            180                 185                 190         
Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr
        195                 200                 205             
Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr
    210                 215                 220                 
Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu
225                 230                 235                 240 
Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys
                245                 250                 255     
Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly
            260                 265                 270         
Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro
        275                 280                 285             
Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn
    290                 295                 300                 
Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly
305                 310                 315                 320 
Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn
                325                 330                 335     
Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln
            340                 345                 350         
Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn
        355                 360                 365             
Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly
    370                 375                 380                 
Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn
385                 390                 395                 400 
Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu
                405                 410                 415     
Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe
            420                 425                 430         
Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe
        435                 440                 445             
Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala
    450                 455                 460                 
Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln
465                 470                 475                 480 
Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe
                485                 490                 495     
Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys
            500                 505                 510         
Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr
        515                 520                 525             
Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg
    530                 535                 540                 
Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp
545                 550                 555                 560 
Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro
                565                 570                 575     
Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn
            580                 585                 590         
Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser
        595                 600                 605             
Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val
    610                 615                 620                 
Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His
625                 630                 635                 640 
Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser
                645                 650                 655     
Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val
            660                 665                 670         
Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser
        675                 680                 685             
Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu
    690                 695                 700                 
Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr
705                 710                 715                 720 
Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile
                725                 730                 735     
Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg
            740                 745                 750         
Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn
        755                 760                 765             
Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val
    770                 775                 780                 
Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg
785                 790                 795                 800 
Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser
                805                 810                 815     
Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu
            820                 825                 830         
Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu
        835                 840                 845             
Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser
    850                 855                 860                 
Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser
865                 870                 875                 880 
Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser
                885                 890                 895     
Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro
            900                 905                 910         
Pro Gln Val Glu Lys Lys Gly Gln
        915                 920 


<210> 6046
<211> 1800
<212> PRT
<213> Homo sapiens

<400> 6046
Met Phe Asn Lys Ser Phe Gly Thr Pro Phe Gly Gly Gly Thr Gly Gly
 1               5                  10                  15      
Phe Gly Thr Thr Ser Thr Phe Gly Gln Asn Thr Gly Phe Gly Thr Thr
            20                  25                  30          
Ser Gly Gly Ala Phe Gly Thr Ser Ala Phe Gly Ser Ser Asn Asn Thr
        35                  40                  45              
Gly Gly Leu Phe Gly Asn Ser Gln Thr Lys Pro Gly Gly Leu Phe Gly
    50                  55                  60                  
Thr Ser Ser Phe Ser Gln Pro Ala Thr Ser Thr Ser Thr Gly Phe Gly
65                  70                  75                  80  
Phe Gly Thr Ser Thr Gly Thr Ala Asn Thr Leu Phe Gly Thr Ala Ser
                85                  90                  95      
Thr Gly Thr Ser Leu Phe Ser Ser Gln Asn Asn Ala Phe Ala Gln Asn
            100                 105                 110         
Lys Pro Thr Gly Phe Gly Asn Phe Gly Thr Ser Thr Ser Ser Gly Gly
        115                 120                 125             
Leu Phe Gly Thr Thr Asn Thr Thr Ser Asn Pro Phe Gly Ser Thr Ser
    130                 135                 140                 
Gly Ser Leu Phe Gly Pro Ser Ser Phe Thr Ala Ala Pro Thr Gly Thr
145                 150                 155                 160 
Thr Ile Lys Phe Asn Pro Pro Thr Gly Thr Asp Thr Met Val Lys Ala
                165                 170                 175     
Gly Val Ser Thr Asn Ile Ser Thr Lys His Gln Cys Ile Thr Ala Met
            180                 185                 190         
Lys Glu Tyr Glu Ser Lys Ser Leu Glu Glu Leu Arg Leu Glu Asp Tyr
        195                 200                 205             
Gln Ala Asn Arg Lys Gly Pro Gln Asn Gln Val Gly Ala Gly Thr Thr
    210                 215                 220                 
Thr Gly Leu Phe Gly Ser Ser Pro Ala Thr Ser Ser Ala Thr Gly Leu
225                 230                 235                 240 
Phe Ser Ser Ser Thr Thr Asn Ser Gly Phe Ala Tyr Gly Gln Asn Lys
                245                 250                 255     
Thr Ala Phe Gly Thr Ser Thr Thr Gly Phe Gly Thr Asn Pro Gly Gly
            260                 265                 270         
Leu Phe Gly Gln Gln Asn Gln Gln Thr Thr Ser Leu Phe Ser Lys Pro
        275                 280                 285             
Phe Gly Gln Ala Thr Thr Thr Gln Asn Thr Gly Phe Ser Phe Gly Asn
    290                 295                 300                 
Thr Ser Thr Ile Gly Gln Pro Ser Thr Asn Thr Met Gly Leu Phe Gly
305                 310                 315                 320 
Val Thr Gln Ala Ser Gln Pro Gly Gly Leu Phe Gly Thr Ala Thr Asn
                325                 330                 335     
Thr Ser Thr Gly Thr Ala Phe Gly Thr Gly Thr Gly Leu Phe Gly Gln
            340                 345                 350         
Thr Asn Thr Gly Phe Gly Ala Val Gly Ser Thr Leu Phe Gly Asn Asn
        355                 360                 365             
Lys Leu Thr Thr Phe Gly Ser Ser Thr Thr Ser Ala Pro Ser Phe Gly
    370                 375                 380                 
Thr Thr Ser Gly Gly Leu Phe Gly Phe Gly Thr Asn Thr Ser Gly Asn
385                 390                 395                 400 
Ser Ile Phe Gly Ser Lys Pro Ala Pro Gly Thr Leu Gly Thr Gly Leu
                405                 410                 415     
Gly Ala Gly Phe Gly Thr Ala Leu Gly Ala Gly Gln Ala Ser Leu Phe
            420                 425                 430         
Gly Asn Asn Gln Pro Lys Ile Gly Gly Pro Leu Gly Thr Gly Ala Phe
        435                 440                 445             
Gly Ala Pro Gly Phe Asn Thr Thr Thr Ala Thr Leu Gly Phe Gly Ala
    450                 455                 460                 
Pro Gln Ala Pro Val Ala Leu Thr Asp Pro Asn Ala Ser Ala Ala Gln
465                 470                 475                 480 
Gln Ala Val Leu Gln Gln His Ile Asn Ser Leu Thr Tyr Ser Pro Phe
                485                 490                 495     
Gly Asp Ser Pro Leu Phe Arg Asn Pro Met Ser Asp Pro Lys Lys Lys
            500                 505                 510         
Glu Glu Arg Leu Lys Pro Thr Asn Pro Ala Ala Gln Lys Ala Leu Thr
        515                 520                 525             
Thr Pro Thr His Tyr Lys Leu Thr Pro Arg Pro Ala Thr Arg Val Arg
    530                 535                 540                 
Pro Lys Ala Leu Gln Thr Thr Gly Thr Ala Lys Ser His Leu Phe Asp
545                 550                 555                 560 
Gly Leu Asp Asp Asp Glu Pro Ser Leu Ala Asn Gly Ala Phe Met Pro
                565                 570                 575     
Lys Lys Ser Ile Lys Lys Leu Val Leu Lys Asn Leu Asn Asn Ser Asn
            580                 585                 590         
Leu Phe Ser Pro Val Asn Arg Asp Ser Glu Asn Leu Ala Ser Pro Ser
        595                 600                 605             
Glu Tyr Pro Glu Asn Gly Glu Arg Phe Ser Phe Leu Ser Lys Pro Val
    610                 615                 620                 
Asp Glu Asn His Gln Gln Asp Gly Asp Glu Asp Ser Leu Val Ser His
625                 630                 635                 640 
Phe Tyr Thr Asn Pro Ile Ala Lys Pro Ile Pro Gln Thr Pro Glu Ser
                645                 650                 655     
Ala Gly Asn Lys His Ser Asn Ser Asn Ser Val Asp Asp Thr Ile Val
            660                 665                 670         
Ala Leu Asn Met Arg Ala Ala Leu Arg Asn Gly Leu Glu Gly Ser Ser
        675                 680                 685             
Glu Glu Thr Ser Phe His Asp Glu Ser Leu Gln Asp Asp Arg Glu Glu
    690                 695                 700                 
Ile Glu Asn Asn Ser Tyr His Met His Pro Ala Gly Ile Ile Leu Thr
705                 710                 715                 720 
Lys Val Gly Tyr Tyr Thr Ile Pro Ser Met Asp Asp Leu Ala Lys Ile
                725                 730                 735     
Thr Asn Glu Lys Gly Glu Cys Ile Val Ser Asp Phe Thr Ile Gly Arg
            740                 745                 750         
Lys Gly Tyr Gly Ser Ile Tyr Phe Glu Gly Asp Val Asn Leu Thr Asn
        755                 760                 765             
Leu Asn Leu Asp Asp Ile Val His Ile Arg Arg Lys Glu Val Val Val
    770                 775                 780                 
Tyr Leu Asp Asp Asn Gln Lys Pro Pro Val Gly Glu Gly Leu Asn Arg
785                 790                 795                 800 
Lys Ala Glu Val Thr Leu Asp Gly Val Trp Pro Thr Asp Lys Thr Ser
                805                 810                 815     
Arg Cys Leu Ile Lys Ser Pro Asp Arg Leu Ala Asp Ile Asn Tyr Glu
            820                 825                 830         
Gly Arg Leu Glu Ala Val Ser Arg Lys Gln Gly Ala Gln Phe Lys Glu
        835                 840                 845             
Tyr Arg Pro Glu Thr Gly Ser Trp Val Phe Lys Val Ser His Phe Ser
    850                 855                 860                 
Lys Tyr Gly Leu Gln Asp Ser Asp Glu Glu Glu Glu Glu His Pro Ser
865                 870                 875                 880 
Lys Thr Ser Thr Lys Lys Leu Lys Thr Ala Pro Leu Pro Pro Ala Ser
                885                 890                 895     
Gln Thr Thr Pro Leu Gln Met Ala Leu Asn Gly Lys Pro Ala Pro Pro
            900                 905                 910         
Pro Gln Ser Gln Ser Pro Glu Val Glu Gln Leu Gly Arg Val Val Glu
        915                 920                 925             
Leu Asp Ser Asp Met Val Asp Ile Thr Gln Glu Pro Val Leu Asp Thr
    930                 935                 940                 
Met Leu Glu Glu Ser Met Pro Glu Asp Gln Glu Pro Val Ser Ala Ser
945                 950                 955                 960 
Thr His Ile Ala Ser Ser Leu Gly Ile Asn Pro His Val Leu Gln Ile
                965                 970                 975     
Met Lys Ala Ser Leu Leu Thr Asp Glu Glu Asp Val Asp Met Ala Leu
            980                 985                 990         
Asp Gln Arg Phe Ser Arg Leu Pro Ser Lys Ala Asp Thr Ser Gln Glu
        995                 1000                1005            
Ile Cys Ser Pro Arg Leu Pro Ile Ser Ala Ser His Ser Ser Lys Thr
    1010                1015                1020                
Arg Ser Leu Val Gly Gly Leu Leu Gln Ser Lys Phe Thr Ser Gly Ala
1025                1030                1035                1040
Phe Leu Ser Pro Ser Val Ser Val Gln Glu Cys Arg Thr Pro Arg Ala
                1045                1050                1055    
Ala Ser Leu Met Asn Ile Pro Ser Thr Ser Ser Trp Ser Val Pro Pro
            1060                1065                1070        
Pro Leu Thr Ser Val Phe Thr Met Pro Ser Pro Ala Pro Glu Val Pro
        1075                1080                1085            
Leu Lys Thr Val Gly Thr Arg Arg Gln Leu Gly Leu Val Pro Arg Glu
    1090                1095                1100                
Lys Ser Val Thr Tyr Gly Lys Gly Lys Leu Leu Met Asp Met Ala Leu
1105                1110                1115                1120
Phe Met Gly Arg Ser Phe Arg Val Gly Trp Gly Pro Asn Trp Thr Leu
                1125                1130                1135    
Ala Asn Ser Gly Glu Gln Leu Asn Gly Ser His Glu Leu Glu Asn His
            1140                1145                1150        
Gln Ile Ala Asp Ser Met Glu Phe Gly Phe Leu Pro Asn Pro Val Ala
        1155                1160                1165            
Val Lys Pro Leu Thr Glu Ser Pro Phe Lys Val His Leu Glu Lys Leu
    1170                1175                1180                
Ser Leu Arg Gln Arg Lys Pro Asp Glu Asp Met Lys Leu Tyr Gln Thr
1185                1190                1195                1200
Pro Leu Glu Leu Lys Leu Lys His Ser Thr Val His Val Asp Glu Leu
                1205                1210                1215    
Cys Pro Leu Ile Val Pro Asn Leu Gly Val Ala Val Ile His Asp Tyr
            1220                1225                1230        
Ala Asp Trp Val Lys Glu Ala Ser Gly Asp Leu Pro Glu Ala Gln Ile
        1235                1240                1245            
Val Lys His Trp Ser Leu Thr Trp Thr Leu Cys Glu Ala Leu Trp Gly
    1250                1255                1260                
His Leu Lys Glu Leu Asp Ser Gln Leu Asn Glu Pro Arg Glu Tyr Ile
1265                1270                1275                1280
Gln Ile Leu Glu Arg Arg Arg Ala Phe Ser Arg Trp Leu Ser Cys Thr
                1285                1290                1295    
Ala Thr Pro Gln Ile Glu Glu Glu Val Ser Leu Thr Gln Lys Asn Ser
            1300                1305                1310        
Pro Val Glu Ala Val Phe Ser Tyr Leu Thr Gly Lys Arg Ile Ser Glu
        1315                1320                1325            
Ala Cys Ser Leu Ala Gln Gln Ser Gly Asp His Arg Leu Ala Leu Leu
    1330                1335                1340                
Leu Ser Gln Phe Val Gly Ser Gln Ser Val Arg Glu Leu Leu Thr Met
1345                1350                1355                1360
Gln Leu Val Asp Trp His Gln Leu Gln Ala Asp Ser Phe Ile Gln Asp
                1365                1370                1375    
Glu Arg Leu Arg Ile Phe Ala Leu Leu Ala Gly Lys Pro Val Trp Gln
            1380                1385                1390        
Leu Ser Glu Lys Lys Gln Ile Asn Val Cys Ser Gln Leu Asp Trp Lys
        1395                1400                1405            
Arg Ser Leu Ala Ile His Leu Trp Tyr Leu Leu Pro Pro Thr Ala Ser
    1410                1415                1420                
Ile Ser Arg Ala Leu Ser Met Tyr Glu Glu Ala Phe Gln Asn Thr Ser
1425                1430                1435                1440
Asp Ser Asp Arg Tyr Ala Cys Ser Pro Leu Pro Ser Tyr Leu Glu Gly
                1445                1450                1455    
Ser Gly Cys Val Ile Ala Glu Glu Gln Asn Ser Gln Thr Pro Leu Arg
            1460                1465                1470        
Asp Val Cys Phe His Leu Leu Lys Leu Tyr Ser Asp Arg His Tyr Asp
        1475                1480                1485            
Leu Asn Gln Leu Leu Glu Pro Arg Ser Ile Thr Ala Asp Pro Leu Asp
    1490                1495                1500                
Tyr Arg Leu Ser Trp His Leu Trp Glu Val Leu Arg Ala Leu Asn Tyr
1505                1510                1515                1520
Thr His Leu Ser Ala Gln Cys Glu Gly Val Leu Gln Ala Ser Tyr Ala
                1525                1530                1535    
Gly Gln Leu Glu Ser Glu Gly Leu Trp Glu Trp Ala Ile Phe Val Leu
            1540                1545                1550        
Leu His Ile Asp Asn Ser Gly Ile Arg Glu Lys Ala Val Arg Glu Leu
        1555                1560                1565            
Leu Thr Arg His Cys Gln Leu Leu Glu Thr Pro Glu Ser Trp Ala Lys
    1570                1575                1580                
Glu Thr Phe Leu Thr Gln Lys Leu Arg Val Pro Ala Lys Trp Ile His
1585                1590                1595                1600
Glu Ala Lys Ala Val Arg Ala His Met Glu Ser Asp Lys His Leu Glu
                1605                1610                1615    
Ala Leu Cys Leu Phe Lys Ala Glu His Trp Asn Arg Cys His Lys Leu
            1620                1625                1630        
Ile Ile Arg His Leu Ala Ser Asp Ala Ile Ile Asn Glu Asn Tyr Asp
        1635                1640                1645            
Tyr Leu Lys Gly Phe Leu Glu Asp Leu Ala Pro Pro Glu Arg Ser Ser
    1650                1655                1660                
Leu Ile Gln Asp Trp Glu Thr Ser Gly Leu Val Tyr Leu Asp Tyr Ile
1665                1670                1675                1680
Arg Val Ile Glu Met Leu Arg His Ile Gln Gln Val Asp Cys Ser Gly
                1685                1690                1695    
Asn Asp Leu Glu Gln Leu His Ile Lys Val Thr Ser Leu Cys Ser Arg
            1700                1705                1710        
Ile Glu Gln Ile Gln Cys Tyr Ser Ala Lys Asp Arg Leu Ala Gln Ser
        1715                1720                1725            
Asp Met Ala Lys Arg Val Ala Asn Leu Leu Arg Val Val Leu Ser Leu
    1730                1735                1740                
His His Pro Pro Asp Arg Thr Ser Asp Ser Thr Pro Asp Pro Gln Arg
1745                1750                1755                1760
Val Pro Leu Arg Leu Leu Ala Pro His Ile Gly Arg Leu Pro Met Pro
                1765                1770                1775    
Glu Asp Tyr Ala Met Asp Glu Leu Arg Ser Leu Thr Gln Ser Tyr Leu
            1780                1785                1790        
Arg Glu Leu Ala Val Gly Ser Leu
        1795                1800


<210> 6047
<211> 180
<212> PRT
<213> Homo sapiens

<400> 6047
Asn Asn Phe Ser Thr Glu Ile Asn Thr Thr Ser Ile Leu Val Gly Pro
 1               5                  10                  15      
Leu Val Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Arg Val
            20                  25                  30          
Lys Phe Ser Asn Thr Ile Asp Thr Thr Asn Ser Gln Cys Ile Arg Trp
        35                  40                  45              
Val Thr Pro Pro Thr Gln Ile Val Cys Leu Pro Ser Gly Ile Phe Phe
    50                  55                  60                  
Val Cys Gly Thr Ser Ala Tyr His Cys Leu Asn Gly Phe Ser Glu Ser
65                  70                  75                  80  
Met Cys Phe Leu Ser Phe Leu Val His Pro Met Thr Ile Tyr Thr Glu
                85                  90                  95      
Gln Asp Leu Tyr Asn Tyr Val Val Pro Lys Pro Arg Asn Lys Arg Val
            100                 105                 110         
Pro Ile Leu Pro Phe Val Ile Arg Ala Gly Met Leu Gly Arg Leu Gly
        115                 120                 125             
Thr Gly Met Gly Ser Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu
    130                 135                 140                 
Ser Gln Glu Leu Asn Gly Asp Met Glu Arg Val Ala Asp Ser Leu Val
145                 150                 155                 160 
Thr Leu Gln Asp Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn
                165                 170                 175     
Arg Arg Ala Leu
            180 


<210> 6048
<211> 1496
<212> PRT
<213> Homo sapiens

<400> 6048
Met Ser Leu Thr Ser Trp Phe Leu Val Ser Ser Gly Gly Thr Arg His
 1               5                  10                  15      
Arg Leu Pro Arg Glu Met Ile Phe Val Gly Arg Asp Asp Cys Glu Leu
            20                  25                  30          
Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr
        35                  40                  45              
Asp Ala Ser Thr Asp Glu His Leu Val Lys Asp Leu Gly Ser Leu Asn
    50                  55                  60                  
Gly Thr Phe Val Asn Asp Val Arg Ile Pro Glu Gln Thr Tyr Ile Thr
65                  70                  75                  80  
Leu Lys Leu Glu Asp Lys Leu Arg Phe Gly Tyr Asp Ile Leu Lys Trp
                85                  90                  95      
Phe Tyr Pro Arg Leu His Thr Asn Leu Phe Thr Val Val Gln Gly Glu
            100                 105                 110         
Met Arg Val Pro Glu Glu Ala Leu Lys His Glu Lys Phe Thr Ile Gln
        115                 120                 125             
Leu Gln Leu Ser Gln Lys Ser Ser Glu Ser Glu Leu Ser Lys Ser Ala
    130                 135                 140                 
Ser Ala Lys Ser Ile Asp Ser Lys Val Ala Asp Ala Ala Thr Glu Val
145                 150                 155                 160 
Gln His Lys Thr Thr Glu Ala Leu Lys Ser Glu Glu Lys Ala Met Asp
                165                 170                 175     
Ile Ser Ala Met Pro Arg Gly Thr Pro Leu Tyr Gly Gln Pro Ser Trp
            180                 185                 190         
Trp Gly Asp Asp Glu Val Asp Glu Lys Arg Ala Phe Lys Thr Asn Gly
        195                 200                 205             
Lys Pro Glu Glu Lys Asn His Glu Ala Gly Thr Ser Gly Cys Gly Ile
    210                 215                 220                 
Asp Ala Lys Gln Val Glu Glu Gln Ser Ala Ala Ala Asn Glu Glu Val
225                 230                 235                 240 
Leu Phe Pro Phe Cys Arg Glu Pro Ser Tyr Phe Glu Ile Pro Thr Lys
                245                 250                 255     
Glu Phe Gln Gln Pro Ser Gln Ile Thr Glu Ser Thr Ile His Glu Ile
            260                 265                 270         
Pro Thr Lys Asp Thr Pro Ser Ser His Ile Thr Gly Ala Gly His Ala
        275                 280                 285             
Ser Phe Thr Ile Glu Phe Asp Asp Ser Thr Pro Gly Lys Val Thr Ile
    290                 295                 300                 
Arg Asp His Val Thr Lys Phe Thr Ser Asp Gln Arg His Lys Ser Lys
305                 310                 315                 320 
Lys Ser Ser Pro Gly Thr Gln Asp Leu Leu Gly Ile Gln Thr Gly Met
                325                 330                 335     
Met Ala Pro Glu Asn Lys Val Ala Asp Trp Leu Ala Gln Asn Asn Pro
            340                 345                 350         
Pro Gln Met Leu Trp Glu Arg Thr Glu Glu Asp Ser Lys Ser Ile Lys
        355                 360                 365             
Ser Asp Val Pro Val Tyr Leu Lys Arg Leu Lys Gly Asn Lys His Asp
    370                 375                 380                 
Asp Gly Thr Gln Ser Asp Ser Glu Asn Ala Gly Ala His Arg Arg Cys
385                 390                 395                 400 
Ser Lys Arg Ala Thr Leu Glu Glu His Leu Arg Arg His His Ser Glu
                405                 410                 415     
His Lys Lys Leu Gln Lys Val Gln Ala Thr Glu Lys His Gln Asp Gln
            420                 425                 430         
Ala Val Val Phe Gly Val Asp Asp Asn Gln Asp Tyr Asn Arg Pro Val
        435                 440                 445             
Ile Asn Glu Lys His Lys Asp Leu Ile Lys Asp Trp Ala Leu Ser Ser
    450                 455                 460                 
Ala Ala Ala Val Met Glu Glu Arg Lys Pro Leu Thr Thr Ser Gly Phe
465                 470                 475                 480 
His His Ser Glu Glu Gly Thr Ser Ser Ser Gly Ser Lys Arg Trp Val
                485                 490                 495     
Ser Gln Trp Ala Ser Leu Ala Ala Asn His Thr Arg His Asp Gln Glu
            500                 505                 510         
Glu Arg Ile Met Glu Phe Ser Ala Pro Leu Pro Leu Glu Asn Glu Thr
        515                 520                 525             
Glu Ile Ser Glu Ser Gly Met Thr Val Arg Ser Thr Gly Ser Ala Thr
    530                 535                 540                 
Ser Leu Ala Ser Gln Gly Glu Arg Arg Arg Arg Thr Leu Pro Gln Leu
545                 550                 555                 560 
Pro Asn Glu Glu Lys Ser Leu Glu Ser His Arg Ala Lys Val Val Thr
                565                 570                 575     
Gln Arg Ser Glu Ile Gly Glu Lys Gln Asp Thr Glu Leu Gln Glu Lys
            580                 585                 590         
Glu Thr Pro Thr Gln Val Tyr Gln Lys Asp Lys Gln Asp Ala Asp Arg
        595                 600                 605             
Pro Leu Ser Lys Met Asn Arg Ala Val Asn Gly Glu Thr Leu Lys Thr
    610                 615                 620                 
Gly Gly Asp Asn Lys Thr Leu Leu His Leu Gly Ser Ser Ala Pro Gly
625                 630                 635                 640 
Lys Glu Lys Ser Glu Thr Asp Lys Glu Thr Ser Leu Val Lys Gln Thr
                645                 650                 655     
Leu Ala Lys Leu Gln Gln Gln Glu Gln Arg Glu Glu Ala Gln Trp Thr
            660                 665                 670         
Pro Thr Lys Leu Ser Ser Lys Asn Val Ser Gly Gln Thr Asp Lys Cys
        675                 680                 685             
Arg Glu Glu Thr Phe Lys Gln Glu Ser Gln Pro Pro Glu Lys Asn Ser
    690                 695                 700                 
Gly His Ser Thr Ser Lys Gly Asp Arg Val Ala Gln Ser Glu Ser Lys
705                 710                 715                 720 
Arg Arg Lys Ala Glu Glu Ile Leu Lys Ser Gln Thr Pro Lys Gly Gly
                725                 730                 735     
Asp Lys Lys Glu Ser Ser Lys Ser Leu Val Arg Gln Gly Ser Phe Thr
            740                 745                 750         
Ile Glu Lys Pro Ser Pro Asn Ile Pro Ile Glu Leu Ile Pro His Ile
        755                 760                 765             
Asn Lys Gln Thr Ser Ser Thr Pro Ser Ser Leu Ala Leu Thr Ser Ala
    770                 775                 780                 
Ser Arg Ile Arg Glu Arg Ser Glu Ser Leu Asp Pro Asp Ser Ser Met
785                 790                 795                 800 
Asp Thr Thr Leu Ile Leu Lys Asp Thr Glu Ala Val Met Ala Phe Leu
                805                 810                 815     
Glu Ala Lys Leu Arg Glu Asp Asn Lys Thr Asp Glu Gly Pro Asp Thr
            820                 825                 830         
Pro Ser Tyr Asn Arg Asp Asn Ser Ile Ser Pro Glu Ser Asp Val Asp
        835                 840                 845             
Thr Ala Ser Thr Ile Ser Leu Val Thr Gly Glu Thr Glu Arg Lys Ser
    850                 855                 860                 
Thr Gln Lys Arg Lys Ser Phe Thr Ser Leu Tyr Lys Asp Arg Cys Ser
865                 870                 875                 880 
Thr Gly Ser Pro Ser Lys Asp Val Thr Lys Ser Ser Ser Ser Gly Ala
                885                 890                 895     
Arg Glu Lys Met Glu Lys Lys Thr Lys Ser Arg Ser Thr Asp Val Gly
            900                 905                 910         
Ser Arg Ala Asp Gly Arg Lys Phe Val Gln Ser Ser Gly Arg Ile Arg
        915                 920                 925             
Gln Pro Ser Val Asp Leu Thr Asp Asp Asp Gln Thr Ser Ser Val Pro
    930                 935                 940                 
His Ser Ala Ile Ser Asp Ile Met Ser Ser Asp Gln Glu Thr Tyr Ser
945                 950                 955                 960 
Cys Lys Pro His Gly Arg Thr Pro Leu Thr Ser Ala Asp Glu His Val
                965                 970                 975     
His Ser Lys Leu Glu Gly Ser Lys Val Thr Lys Ser Lys Thr Ser Pro
            980                 985                 990         
Val Val Ser Gly Ser Ser Ser Lys Ser Thr Thr Leu Pro Arg Pro Arg
        995                 1000                1005            
Pro Thr Arg Thr Ser Leu Leu Arg Arg Ala Arg Leu Gly Glu Ala Ser
    1010                1015                1020                
Asp Ser Glu Leu Ala Asp Ala Asp Lys Ala Ser Val Ala Ser Glu Val
1025                1030                1035                1040
Ser Thr Thr Ser Ser Thr Ser Lys Pro Pro Thr Gly Arg Arg Asn Ile
                1045                1050                1055    
Ser Arg Ile Asp Leu Leu Ala Gln Pro Arg Arg Thr Arg Leu Gly Ser
            1060                1065                1070        
Leu Ser Ala Arg Ser Asp Ser Glu Ala Thr Ile Ser Arg Ser Ser Ala
        1075                1080                1085            
Ser Ser Arg Thr Ala Glu Ala Ile Ile Arg Ser Gly Ala Arg Leu Val
    1090                1095                1100                
Pro Ser Asp Lys Phe Ser Pro Arg Ile Arg Ala Asn Ser Ile Ser Arg
1105                1110                1115                1120
Leu Ser Asp Ser Lys Val Lys Ser Met Thr Ser Ala His Gly Ser Ala
                1125                1130                1135    
Ser Val Asn Ser Arg Trp Arg Arg Phe Pro Thr Asp Tyr Ala Ser Thr
            1140                1145                1150        
Ser Glu Asp Glu Phe Gly Ser Asn Arg Asn Ser Pro Lys His Thr Arg
        1155                1160                1165            
Leu Arg Thr Ser Pro Ala Leu Lys Thr Thr Arg Leu Gln Ser Ala Gly
    1170                1175                1180                
Ser Ala Met Pro Thr Ser Ser Ser Phe Lys His Arg Ile Lys Glu Gln
1185                1190                1195                1200
Glu Asp Tyr Ile Arg Asp Trp Thr Ala His Arg Glu Glu Ile Ala Arg
                1205                1210                1215    
Ile Ser Gln Asp Leu Ala Leu Ile Ala Arg Glu Ile Asn Asp Val Ala
            1220                1225                1230        
Gly Glu Ile Asp Ser Val Thr Ser Ser Gly Thr Ala Pro Ser Thr Thr
        1235                1240                1245            
Val Ser Thr Ala Ala Thr Thr Pro Gly Ser Ala Ile Asp Thr Arg Glu
    1250                1255                1260                
Glu Leu Val Asp Arg Val Phe Asp Glu Ser Leu Asn Phe Arg Lys Ile
1265                1270                1275                1280
Pro Pro Leu Val His Ser Lys Thr Pro Glu Gly Asn Asn Gly Arg Ser
                1285                1290                1295    
Gly Asp Pro Arg Pro Gln Ala Ala Glu Pro Pro Asp His Leu Thr Ile
            1300                1305                1310        
Thr Arg Arg Arg Thr Trp Ser Arg Asp Glu Val Met Gly Asp Asn Leu
        1315                1320                1325            
Leu Leu Ser Ser Val Phe Gln Phe Ser Lys Lys Ile Arg Gln Ser Ile
    1330                1335                1340                
Asp Lys Thr Ala Gly Lys Ile Arg Ile Leu Phe Lys Asp Lys Asp Arg
1345                1350                1355                1360
Asn Trp Asp Asp Ile Glu Ser Lys Leu Arg Ala Glu Ser Glu Val Pro
                1365                1370                1375    
Ile Val Lys Thr Ser Ser Met Glu Ile Ser Ser Ile Leu Gln Glu Leu
            1380                1385                1390        
Lys Arg Val Glu Lys Gln Leu Gln Ala Ile Asn Ala Met Ile Asp Pro
        1395                1400                1405            
Asp Gly Thr Leu Glu Ala Leu Asn Asn Met Gly Phe Pro Ser Ala Met
    1410                1415                1420                
Leu Pro Ser Pro Pro Lys Gln Lys Ser Ser Pro Val Asn Asn His His
1425                1430                1435                1440
Ser Pro Gly Gln Thr Pro Thr Leu Gly Gln Pro Glu Ala Arg Ala Leu
                1445                1450                1455    
His Pro Ala Ala Val Ser Ala Ala Ala Glu Phe Glu Asn Ala Glu Ser
            1460                1465                1470        
Glu Ala Asp Phe Ser Ile His Phe Asn Arg Phe Asn Pro Asp Gly Glu
        1475                1480                1485            
Glu Glu Asp Val Thr Val Gln Glu
    1490                1495    


<210> 6049
<211> 1594
<212> PRT
<213> Homo sapiens

<400> 6049
Met Ser Leu Thr Ser Trp Phe Leu Val Ser Ser Gly Gly Thr Arg His
 1               5                  10                  15      
Arg Leu Pro Arg Glu Met Ile Phe Val Gly Arg Asp Asp Cys Glu Leu
            20                  25                  30          
Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr
        35                  40                  45              
Asp Ala Ser Thr Asp Glu His Leu Val Lys Asp Leu Gly Ser Leu Asn
    50                  55                  60                  
Gly Thr Phe Val Asn Asp Val Arg Ile Pro Glu Gln Thr Tyr Ile Thr
65                  70                  75                  80  
Leu Lys Leu Glu Asp Lys Leu Arg Phe Gly Tyr Asp Ile Leu Lys Trp
                85                  90                  95      
Phe Tyr Pro Arg Leu His Thr Asn Leu Phe Thr Val Val Gln Gly Glu
            100                 105                 110         
Met Arg Val Pro Glu Glu Ala Leu Lys His Glu Lys Phe Thr Ile Gln
        115                 120                 125             
Leu Gln Leu Ser Gln Lys Ser Ser Glu Ser Glu Leu Ser Lys Ser Ala
    130                 135                 140                 
Ser Ala Lys Ser Ile Asp Ser Lys Val Ala Asp Ala Ala Thr Glu Val
145                 150                 155                 160 
Gln His Lys Thr Thr Glu Ala Leu Lys Ser Glu Glu Lys Ala Met Asp
                165                 170                 175     
Ile Ser Ala Met Pro Arg Gly Thr Pro Leu Tyr Gly Gln Pro Ser Trp
            180                 185                 190         
Trp Gly Asp Asp Glu Val Asp Glu Lys Arg Ala Phe Lys Thr Asn Gly
        195                 200                 205             
Lys Pro Glu Glu Lys Asn His Glu Ala Gly Thr Ser Gly Cys Gly Ile
    210                 215                 220                 
Asp Ala Lys Gln Val Glu Glu Gln Ser Ala Ala Ala Asn Glu Glu Val
225                 230                 235                 240 
Leu Phe Pro Phe Cys Arg Glu Pro Ser Tyr Phe Glu Ile Pro Thr Lys
                245                 250                 255     
Glu Phe Gln Gln Pro Ser Gln Ile Thr Glu Ser Thr Ile His Glu Ile
            260                 265                 270         
Pro Thr Lys Asp Thr Pro Ser Ser His Ile Thr Gly Ala Gly His Ala
        275                 280                 285             
Ser Phe Thr Ile Glu Phe Asp Asp Ser Thr Pro Gly Lys Val Thr Ile
    290                 295                 300                 
Arg Asp His Val Thr Lys Phe Thr Ser Asp Gln Arg His Lys Ser Lys
305                 310                 315                 320 
Lys Ser Ser Pro Gly Thr Gln Asp Leu Leu Gly Ile Gln Thr Gly Met
                325                 330                 335     
Met Ala Pro Glu Asn Lys Val Ala Asp Trp Leu Ala Gln Asn Asn Pro
            340                 345                 350         
Pro Gln Met Leu Trp Glu Arg Thr Glu Glu Asp Ser Lys Ser Ile Lys
        355                 360                 365             
Ser Asp Val Pro Val Tyr Leu Lys Arg Leu Lys Gly Asn Lys His Asp
    370                 375                 380                 
Asp Gly Thr Gln Ser Asp Ser Glu Asn Ala Gly Ala His Arg Arg Cys
385                 390                 395                 400 
Ser Lys Arg Ala Thr Leu Glu Glu His Leu Arg Arg His His Ser Glu
                405                 410                 415     
His Lys Lys Leu Gln Lys Val Gln Ala Thr Glu Lys His Gln Asp Gln
            420                 425                 430         
Ala Val Thr Ser Ser Ala His His Arg Gly Gly His Gly Val Pro His
        435                 440                 445             
Gly Lys Leu Leu Lys Gln Lys Ser Glu Glu Pro Ser Val Ser Ile Pro
    450                 455                 460                 
Phe Leu Gln Thr Ala Leu Leu Arg Ser Ser Gly Ser Leu Gly His Arg
465                 470                 475                 480 
Pro Ser Gln Glu Met Asp Lys Met Leu Lys Asn Gln Ala Thr Ser Ala
                485                 490                 495     
Thr Ser Glu Lys Asp Asn Asp Asp Asp Gln Ser Asp Lys Gly Thr Tyr
            500                 505                 510         
Thr Ile Glu Leu Glu Asn Pro Asn Ser Glu Glu Val Glu Ala Arg Lys
        515                 520                 525             
Met Ile Asp Lys Val Phe Gly Val Asp Asp Asn Gln Asp Tyr Asn Arg
    530                 535                 540                 
Pro Val Ile Asn Glu Lys His Lys Asp Leu Ile Lys Asp Trp Ala Leu
545                 550                 555                 560 
Ser Ser Ala Ala Ala Val Met Glu Glu Arg Lys Pro Leu Thr Thr Ser
                565                 570                 575     
Gly Phe His His Ser Glu Glu Gly Thr Ser Ser Ser Gly Ser Lys Arg
            580                 585                 590         
Trp Val Ser Gln Trp Ala Ser Leu Ala Ala Asn His Thr Arg His Asp
        595                 600                 605             
Gln Glu Glu Arg Ile Met Glu Phe Ser Ala Pro Leu Pro Leu Glu Asn
    610                 615                 620                 
Glu Thr Glu Ile Ser Glu Ser Gly Met Thr Val Arg Ser Thr Gly Ser
625                 630                 635                 640 
Ala Thr Ser Leu Ala Ser Gln Gly Glu Arg Arg Arg Arg Thr Leu Pro
                645                 650                 655     
Gln Leu Pro Asn Glu Glu Lys Ser Leu Glu Ser His Arg Ala Lys Val
            660                 665                 670         
Val Thr Gln Arg Ser Glu Ile Gly Glu Lys Gln Asp Thr Glu Leu Gln
        675                 680                 685             
Glu Lys Glu Thr Pro Thr Gln Val Tyr Gln Lys Asp Lys Gln Asp Ala
    690                 695                 700                 
Asp Arg Pro Leu Ser Lys Met Asn Arg Ala Val Asn Gly Glu Thr Leu
705                 710                 715                 720 
Lys Thr Gly Gly Asp Asn Lys Thr Leu Leu His Leu Gly Ser Ser Ala
                725                 730                 735     
Pro Gly Lys Glu Lys Ser Glu Thr Asp Lys Glu Thr Ser Leu Val Lys
            740                 745                 750         
Gln Thr Leu Ala Lys Leu Gln Gln Gln Glu Gln Arg Glu Glu Ala Gln
        755                 760                 765             
Trp Thr Pro Thr Lys Leu Ser Ser Lys Asn Val Ser Gly Gln Thr Asp
    770                 775                 780                 
Lys Cys Arg Glu Glu Thr Phe Lys Gln Glu Ser Gln Pro Pro Glu Lys
785                 790                 795                 800 
Asn Ser Gly His Ser Thr Ser Lys Gly Asp Arg Val Ala Gln Ser Glu
                805                 810                 815     
Ser Lys Arg Arg Lys Ala Glu Glu Ile Leu Lys Ser Gln Thr Pro Lys
            820                 825                 830         
Gly Gly Asp Lys Lys Glu Ser Ser Lys Ser Leu Val Arg Gln Gly Ser
        835                 840                 845             
Phe Thr Ile Glu Lys Pro Ser Pro Asn Ile Pro Ile Glu Leu Ile Pro
    850                 855                 860                 
His Ile Asn Lys Gln Thr Ser Ser Thr Pro Ser Ser Leu Ala Leu Thr
865                 870                 875                 880 
Ser Ala Ser Arg Ile Arg Glu Arg Ser Glu Ser Leu Asp Pro Asp Ser
                885                 890                 895     
Ser Met Asp Thr Thr Leu Ile Leu Lys Asp Thr Glu Ala Val Met Ala
            900                 905                 910         
Phe Leu Glu Ala Lys Leu Arg Glu Asp Asn Lys Thr Asp Glu Gly Pro
        915                 920                 925             
Asp Thr Pro Ser Tyr Asn Arg Asp Asn Ser Ile Ser Pro Glu Ser Asp
    930                 935                 940                 
Val Asp Thr Ala Ser Thr Ile Ser Leu Val Thr Gly Glu Thr Glu Arg
945                 950                 955                 960 
Lys Ser Thr Gln Lys Arg Lys Ser Phe Thr Ser Leu Tyr Lys Asp Arg
                965                 970                 975     
Cys Ser Thr Gly Ser Pro Ser Lys Asp Val Thr Lys Ser Ser Ser Ser
            980                 985                 990         
Gly Ala Arg Glu Lys Met Glu Lys Lys Thr Lys Ser Arg Ser Thr Asp
        995                 1000                1005            
Val Gly Ser Arg Ala Asp Gly Arg Lys Phe Val Gln Ser Ser Gly Arg
    1010                1015                1020                
Ile Arg Gln Pro Ser Val Asp Leu Thr Asp Asp Asp Gln Thr Ser Ser
1025                1030                1035                1040
Val Pro His Ser Ala Ile Ser Asp Ile Met Ser Ser Asp Gln Glu Thr
                1045                1050                1055    
Tyr Ser Cys Lys Pro His Gly Arg Thr Pro Leu Thr Ser Ala Asp Glu
            1060                1065                1070        
His Val His Ser Lys Leu Glu Gly Ser Lys Val Thr Lys Ser Lys Thr
        1075                1080                1085            
Ser Pro Val Val Ser Gly Ser Ser Ser Lys Ser Thr Thr Leu Pro Arg
    1090                1095                1100                
Pro Arg Pro Thr Arg Thr Ser Leu Leu Arg Arg Ala Arg Leu Gly Glu
1105                1110                1115                1120
Ala Ser Asp Ser Glu Leu Ala Asp Ala Asp Lys Ala Ser Val Ala Ser
                1125                1130                1135    
Glu Val Ser Thr Thr Ser Ser Thr Ser Lys Pro Pro Thr Gly Arg Arg
            1140                1145                1150        
Asn Ile Ser Arg Ile Asp Leu Leu Ala Gln Pro Arg Arg Thr Arg Leu
        1155                1160                1165            
Gly Ser Leu Ser Ala Arg Ser Asp Ser Glu Ala Thr Ile Ser Arg Ser
    1170                1175                1180                
Ser Ala Ser Ser Arg Thr Ala Glu Ala Ile Ile Arg Ser Gly Ala Arg
1185                1190                1195                1200
Leu Val Pro Ser Asp Lys Phe Ser Pro Arg Ile Arg Ala Asn Ser Ile
                1205                1210                1215    
Ser Arg Leu Ser Asp Ser Lys Val Lys Ser Met Thr Ser Ala His Gly
            1220                1225                1230        
Ser Ala Ser Val Asn Ser Arg Trp Arg Arg Phe Pro Thr Asp Tyr Ala
        1235                1240                1245            
Ser Thr Ser Glu Asp Glu Phe Gly Ser Asn Arg Asn Ser Pro Lys His
    1250                1255                1260                
Thr Arg Leu Arg Thr Ser Pro Ala Leu Lys Thr Thr Arg Leu Gln Ser
1265                1270                1275                1280
Ala Gly Ser Ala Met Pro Thr Ser Ser Ser Phe Lys His Arg Ile Lys
                1285                1290                1295    
Glu Gln Glu Asp Tyr Ile Arg Asp Trp Thr Ala His Arg Glu Glu Ile
            1300                1305                1310        
Ala Arg Ile Ser Gln Asp Leu Ala Leu Ile Ala Arg Glu Ile Asn Asp
        1315                1320                1325            
Val Ala Gly Glu Ile Asp Ser Val Thr Ser Ser Gly Thr Ala Pro Ser
    1330                1335                1340                
Thr Thr Val Ser Thr Ala Ala Thr Thr Pro Gly Ser Ala Ile Asp Thr
1345                1350                1355                1360
Arg Glu Glu Leu Val Asp Arg Val Phe Asp Glu Ser Leu Asn Phe Arg
                1365                1370                1375    
Lys Ile Pro Pro Leu Val His Ser Lys Thr Pro Glu Gly Asn Asn Gly
            1380                1385                1390        
Arg Ser Gly Asp Pro Arg Pro Gln Ala Ala Glu Pro Pro Asp His Leu
        1395                1400                1405            
Thr Ile Thr Arg Arg Arg Thr Trp Ser Arg Asp Glu Val Met Gly Asp
    1410                1415                1420                
Asn Leu Leu Leu Ser Ser Val Phe Gln Phe Ser Lys Lys Ile Arg Gln
1425                1430                1435                1440
Ser Ile Asp Lys Thr Ala Gly Lys Ile Arg Ile Leu Phe Lys Asp Lys
                1445                1450                1455    
Asp Arg Asn Trp Asp Asp Ile Glu Ser Lys Leu Arg Ala Glu Ser Glu
            1460                1465                1470        
Val Pro Ile Val Lys Thr Ser Ser Met Glu Ile Ser Ser Ile Leu Gln
        1475                1480                1485            
Glu Leu Lys Arg Val Glu Lys Gln Leu Gln Ala Ile Asn Ala Met Ile
    1490                1495                1500                
Asp Pro Asp Gly Thr Leu Glu Ala Leu Asn Asn Met Gly Phe Pro Ser
1505                1510                1515                1520
Ala Met Leu Pro Ser Pro Pro Lys Gln Lys Ser Ser Pro Val Asn Asn
                1525                1530                1535    
His His Ser Pro Gly Gln Thr Pro Thr Leu Gly Gln Pro Glu Ala Arg
            1540                1545                1550        
Ala Leu His Pro Ala Ala Val Ser Ala Ala Ala Glu Phe Glu Asn Ala
        1555                1560                1565            
Glu Ser Glu Ala Asp Phe Ser Ile His Phe Asn Arg Phe Asn Pro Asp
    1570                1575                1580                
Gly Glu Glu Glu Asp Val Thr Val Gln Glu
1585                1590                


<210> 6050
<211> 694
<212> PRT
<213> Homo sapiens

<400> 6050
Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu
 1               5                  10                  15      
Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu
            20                  25                  30          
Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro
        35                  40                  45              
Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser
    50                  55                  60                  
Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu
65                  70                  75                  80  
Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp
                85                  90                  95      
Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser
            100                 105                 110         
Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp
        115                 120                 125             
Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn Thr Asn Thr Ser
    130                 135                 140                 
Asn Asn Thr Glu Glu Glu Lys Lys Thr Lys Lys Lys Asp Ala Ile Val
145                 150                 155                 160 
Val Asp Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala
                165                 170                 175     
Leu Pro Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe
            180                 185                 190         
Asp Glu Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr
        195                 200                 205             
Ser Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr
    210                 215                 220                 
Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp
225                 230                 235                 240 
Gln His Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu
                245                 250                 255     
Val Pro Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu
            260                 265                 270         
Val Arg Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe
        275                 280                 285             
Asp Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly
    290                 295                 300                 
Asn Leu Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile
305                 310                 315                 320 
Tyr Phe Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val
                325                 330                 335     
Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr
            340                 345                 350         
Ile Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu
        355                 360                 365             
Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp
    370                 375                 380                 
Phe Leu Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly
385                 390                 395                 400 
Ser Met Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys
                405                 410                 415     
Ile Asp Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp
            420                 425                 430         
Leu Glu Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys
        435                 440                 445             
Lys Thr Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu
    450                 455                 460                 
Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val
465                 470                 475                 480 
Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu
                485                 490                 495     
Lys Leu Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys
            500                 505                 510         
Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala
        515                 520                 525             
Val Val Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly
    530                 535                 540                 
Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser
545                 550                 555                 560 
Gly Asn Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu
                565                 570                 575     
Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro
            580                 585                 590         
Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys
        595                 600                 605             
Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys
    610                 615                 620                 
Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu
625                 630                 635                 640 
Gln Thr Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met
                645                 650                 655     
Lys Met Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly
            660                 665                 670         
Gly Asp Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys
        675                 680                 685             
Thr Glu Asp Lys Gln Gln
    690                 


<210> 6051
<211> 561
<212> PRT
<213> Homo sapiens

<400> 6051
Met Ser Val Arg Tyr Ser Ser Ser Ser Lys Gln Phe Ser Ser Ser Arg
 1               5                  10                  15      
Ser Gly Gly Gly Gly Gly Gly Gly Ser Ser Leu Arg Ile Ser Ser Ser
            20                  25                  30          
Lys Gly Ser Leu Gly Gly Gly Phe Ser Ser Gly Gly Phe Ser Gly Gly
        35                  40                  45              
Ser Phe Ser Arg Gly Ser Ser Gly Gly Gly Cys Phe Gly Gly Ser Ser
    50                  55                  60                  
Gly Gly Tyr Gly Gly Leu Gly Gly Phe Gly Gly Gly Ser Phe Arg Gly
65                  70                  75                  80  
Ser Tyr Gly Ser Ser Ser Phe Gly Gly Ser Tyr Gly Gly Ser Phe Gly
                85                  90                  95      
Gly Gly Ser Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe Gly Gly
            100                 105                 110         
Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly Phe
        115                 120                 125             
Gly Gly Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Val Thr Met Gln
    130                 135                 140                 
Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu
145                 150                 155                 160 
Glu Glu Ser Asn Tyr Glu Leu Glu Gly Lys Ile Lys Glu Arg Tyr Asp
                165                 170                 175     
Gln His Gly Asn Ser Arg Gln Gly Glu Pro Arg Asp Tyr Ser Lys Tyr
            180                 185                 190         
Tyr Lys Thr Ile Asp Asp Leu Lys Asn Gln Ile Leu Asn Leu Thr Thr
        195                 200                 205             
Asp Asn Ala Asn Ile Leu Leu Gln Ile Asp Asn Ala Arg Leu Ala Ala
    210                 215                 220                 
Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Val Ala Leu Arg Gln Ser
225                 230                 235                 240 
Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr
                245                 250                 255     
Leu Thr Gln Ala Asp Leu Glu Met Gln Ile Glu Ser Leu Thr Glu Glu
            260                 265                 270         
Leu Ala Tyr Leu Lys Lys Asn Arg Glu Glu Glu Met Lys His Leu Arg
        275                 280                 285             
Asn Val Ser Thr Gly Asp Val Asn Val Glu Met Asn Ala Ala Pro Gly
    290                 295                 300                 
Val Asp Leu Thr Gln Leu Leu Asn Asn Met Arg Asn Gln Tyr Glu Gln
305                 310                 315                 320 
Leu Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Asn Glu Lys
                325                 330                 335     
Ser Lys Glu Leu Thr Thr Glu Ile Asp Asn Asn Ile Glu Gln Ile Ser
            340                 345                 350         
Ser Tyr Lys Ser Glu Ile Thr Glu Leu Arg Arg Asn Val Gln Ala Leu
        355                 360                 365             
Glu Ile Glu Leu Gln Ser Gln Leu Ala Leu Lys Gln Ser Leu Glu Ala
    370                 375                 380                 
Ser Leu Ala Glu Thr Glu Gly Arg Tyr Cys Val Gln Leu Ser Gln Ile
385                 390                 395                 400 
Gln Ala Gln Ile Ser Ala Leu Glu Glu Gln Leu Gln Glu Ile Arg Ala
                405                 410                 415     
Glu Thr Glu Cys Gln Asn Thr Glu Tyr Gln Gln Leu Thr Asp Ile Lys
            420                 425                 430         
Ile Arg Leu Glu Asn Glu Ile Gln Thr Tyr Arg Ser Leu Leu Glu Gly
        435                 440                 445             
Glu Gly Ser Ser Gly Gly Gly Gly Arg Gly Gly Gly Ser Phe Gly Gly
    450                 455                 460                 
Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Tyr
465                 470                 475                 480 
Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly Gly
                485                 490                 495     
Tyr Gly Gly Gly Ser Phe Gly Gly Gly Gly Gly Gly Tyr Gly Gly Gly
            500                 505                 510         
Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly Ser
        515                 520                 525             
Ser Ser Gly Gly Gly Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Lys
    530                 535                 540                 
Ser Ser Ser Ser Gly Ser Val Gly Glu Ser Ser Ser Lys Gly Pro Arg
545                 550                 555                 560 
Tyr
    


<210> 6052
<211> 593
<212> PRT
<213> Homo sapiens

<400> 6052
Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser
            20                  25                  30          
Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser
        35                  40                  45              
Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly
    50                  55                  60                  
Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe
65                  70                  75                  80  
Gly Gly Gly Ser Phe His Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly
                85                  90                  95      
Ser Tyr Gly Gly Ser Phe Gly Gly Gly Asn Phe Gly Gly Gly Ser Phe
            100                 105                 110         
Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly
        115                 120                 125             
Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly
    130                 135                 140                 
Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr
145                 150                 155                 160 
Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly
                165                 170                 175     
Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu
            180                 185                 190         
Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn
        195                 200                 205             
Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile
    210                 215                 220                 
Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn
225                 230                 235                 240 
Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg
                245                 250                 255     
Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln
            260                 265                 270         
Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu
        275                 280                 285             
Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val
    290                 295                 300                 
Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn
305                 310                 315                 320 
Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala
                325                 330                 335     
Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp
            340                 345                 350         
Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu
        355                 360                 365             
Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala
    370                 375                 380                 
Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr
385                 390                 395                 400 
Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu
                405                 410                 415     
Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr
            420                 425                 430         
Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr
        435                 440                 445             
Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg
    450                 455                 460                 
Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly
465                 470                 475                 480 
Gly Ser Ser Gly Gly Gly Tyr Gly Gly Gly His Gly Gly Ser Ser Gly
                485                 490                 495     
Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly
            500                 505                 510         
Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Gly Ser Ser Ser
        515                 520                 525             
Gly Gly His Gly Gly Ser Ser Ser Gly Gly Tyr Gly Gly Gly Ser Ser
    530                 535                 540                 
Gly Gly Gly Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser
545                 550                 555                 560 
Ser Ser Gly Gly Gly Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Lys
                565                 570                 575     
Ser Ser Ser Ser Gly Ser Val Gly Glu Ser Ser Ser Lys Gly Pro Arg
            580                 585                 590         
Tyr
    


<210> 6053
<211> 584
<212> PRT
<213> Homo sapiens

<400> 6053
Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser
            20                  25                  30          
Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser
        35                  40                  45              
Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly
    50                  55                  60                  
Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe
65                  70                  75                  80  
Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly
                85                  90                  95      
Ser Tyr Gly Gly Ser Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe
            100                 105                 110         
Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly
        115                 120                 125             
Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly
    130                 135                 140                 
Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr
145                 150                 155                 160 
Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly
                165                 170                 175     
Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu
            180                 185                 190         
Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn
        195                 200                 205             
Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile
    210                 215                 220                 
Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn
225                 230                 235                 240 
Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg
                245                 250                 255     
Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln
            260                 265                 270         
Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu
        275                 280                 285             
Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val
    290                 295                 300                 
Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn
305                 310                 315                 320 
Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala
                325                 330                 335     
Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp
            340                 345                 350         
Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu
        355                 360                 365             
Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala
    370                 375                 380                 
Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr
385                 390                 395                 400 
Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu
                405                 410                 415     
Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr
            420                 425                 430         
Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr
        435                 440                 445             
Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg
    450                 455                 460                 
Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly
465                 470                 475                 480 
Gly Ser Ser Gly Gly Gly Tyr Gly Gly Gly His Gly Gly Ser Ser Gly
                485                 490                 495     
Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly
            500                 505                 510         
Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly
        515                 520                 525             
Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly
    530                 535                 540                 
Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly
545                 550                 555                 560 
Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu
                565                 570                 575     
Ser Ser Ser Lys Gly Pro Arg Tyr
            580                 


<210> 6054
<211> 895
<212> PRT
<213> Homo sapiens

<400> 6054
Met Phe Pro Thr Gly Phe Ser Ser Pro Ser Pro Ser Ala Ala Ala Ala
 1               5                  10                  15      
Ala Gln Glu Val Arg Ser Ala Thr Asp Gly Asn Thr Ser Thr Thr Pro
            20                  25                  30          
Pro Thr Ser Ala Lys Lys Arg Lys Leu Asn Ser Ser Ser Ser Ser Ser
        35                  40                  45              
Ser Asn Ser Ser Asn Glu Arg Glu Asp Phe Asp Ser Thr Ser Ser Ser
    50                  55                  60                  
Ser Ser Thr Pro Pro Leu Gln Pro Arg Asp Ser Ala Ser Pro Ser Thr
65                  70                  75                  80  
Ser Ser Phe Cys Leu Gly Val Ser Val Ala Ala Ser Ser His Val Pro
                85                  90                  95      
Ile Gln Lys Lys Leu Arg Phe Glu Asp Thr Leu Gly Phe Val Gly Phe
            100                 105                 110         
Asp Ala Lys Met Ala Glu Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser
        115                 120                 125             
Pro Thr Ala Ala Thr Ser Gln Gln Gln Gln Leu Lys Asn Lys Ser Ile
    130                 135                 140                 
Leu Ile Ser Ser Val Ala Ser Val His His Ala Asn Gly Leu Ala Lys
145                 150                 155                 160 
Ser Ser Thr Thr Val Ser Ser Phe Ala Asn Ser Lys Pro Gly Ser Ala
                165                 170                 175     
Lys Lys Leu Val Ile Lys Asn Phe Lys Asp Lys Pro Lys Leu Pro Glu
            180                 185                 190         
Asn Tyr Thr Asp Glu Thr Trp Gln Lys Leu Lys Glu Ala Val Glu Ala
        195                 200                 205             
Ile Gln Asn Ser Thr Ser Ile Lys Tyr Asn Leu Glu Glu Leu Tyr Gln
    210                 215                 220                 
Ala Val Glu Asn Leu Cys Ser Tyr Lys Ile Ser Ala Asn Leu Tyr Lys
225                 230                 235                 240 
Gln Leu Arg Gln Ile Cys Glu Asp His Ile Lys Ala Gln Ile His Gln
                245                 250                 255     
Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu Lys Lys Ile Asp
            260                 265                 270         
Arg Cys Trp Gln Asn His Cys Arg Gln Met Ile Met Ile Arg Ser Ile
        275                 280                 285             
Phe Leu Phe Leu Asp Arg Thr Tyr Val Leu Gln Asn Ser Met Leu Pro
    290                 295                 300                 
Ser Ile Trp Asp Met Gly Leu Glu Leu Phe Arg Ala His Ile Ile Ser
305                 310                 315                 320 
Asp Gln Lys Val Gln Asn Lys Thr Ile Asp Gly Ile Leu Leu Leu Ile
                325                 330                 335     
Glu Arg Glu Arg Asn Gly Glu Ala Ile Asp Arg Ser Leu Leu Arg Ser
            340                 345                 350         
Leu Leu Ser Met Leu Ser Asp Leu Gln Ile Tyr Gln Asp Ser Phe Glu
        355                 360                 365             
Gln Arg Phe Leu Glu Glu Thr Asn Arg Leu Tyr Ala Ala Glu Gly Gln
    370                 375                 380                 
Lys Leu Met Gln Glu Arg Glu Val Pro Glu Tyr Leu His His Val Asn
385                 390                 395                 400 
Lys Arg Leu Glu Glu Glu Ala Asp Arg Leu Ile Thr Tyr Leu Asp Gln
                405                 410                 415     
Thr Thr Gln Lys Ser Leu Ile Ala Thr Val Glu Lys Gln Leu Leu Gly
            420                 425                 430         
Glu His Leu Thr Ala Ile Leu Gln Lys Gly Leu Asn Asn Leu Leu Asp
        435                 440                 445             
Glu Asn Arg Ile Gln Asp Leu Ser Leu Leu Tyr Gln Leu Phe Ser Arg
    450                 455                 460                 
Val Arg Asp Gly Val Gln Val Leu Leu Gln Gln Trp Ile Glu Tyr Ile
465                 470                 475                 480 
Lys Ala Phe Gly Ser Thr Ile Val Ile Asn Pro Glu Lys Asp Lys Thr
                485                 490                 495     
Met Val Gln Glu Leu Leu Asp Phe Lys Asp Lys Val Asp His Ile Ile
            500                 505                 510         
Asp Ile Cys Phe Leu Lys Asn Glu Lys Phe Ile Asn Ala Met Lys Glu
        515                 520                 525             
Ala Phe Glu Thr Phe Ile Asn Lys Arg Pro Asn Lys Pro Ala Glu Leu
    530                 535                 540                 
Ile Ala Lys Tyr Val Asp Ser Lys Leu Arg Ala Gly Asn Lys Glu Ala
545                 550                 555                 560 
Thr Asp Glu Glu Leu Glu Lys Met Leu Asp Lys Ile Met Ile Ile Phe
                565                 570                 575     
Arg Phe Ile Tyr Gly Lys Asp Val Phe Glu Ala Phe Tyr Lys Lys Asp
            580                 585                 590         
Leu Ala Lys Arg Leu Leu Val Gly Lys Ser Ala Ser Val Asp Ala Glu
        595                 600                 605             
Lys Ser Met Leu Ser Lys Leu Lys His Glu Cys Gly Ala Ala Phe Thr
    610                 615                 620                 
Ser Lys Leu Glu Gly Met Phe Lys Asp Met Glu Leu Ser Lys Asp Ile
625                 630                 635                 640 
Met Ile Gln Phe Lys Gln Tyr Met Gln Asn Gln Asn Val Pro Gly Asn
                645                 650                 655     
Ile Glu Leu Thr Val Asn Ile Leu Thr Met Gly Tyr Trp Pro Thr Tyr
            660                 665                 670         
Val Pro Met Glu Val His Leu Pro Pro Glu Met Val Lys Leu Gln Glu
        675                 680                 685             
Ile Phe Lys Thr Phe Tyr Leu Gly Lys His Ser Gly Arg Lys Leu Gln
    690                 695                 700                 
Trp Gln Ser Thr Leu Gly His Cys Val Leu Lys Ala Glu Phe Lys Glu
705                 710                 715                 720 
Gly Lys Lys Glu Leu Gln Val Ser Leu Phe Gln Thr Leu Val Leu Leu
                725                 730                 735     
Met Phe Asn Glu Gly Glu Glu Phe Ser Leu Glu Glu Ile Lys Gln Ala
            740                 745                 750         
Thr Gly Ile Glu Asp Gly Glu Leu Arg Arg Thr Leu Gln Ser Leu Ala
        755                 760                 765             
Cys Gly Lys Ala Arg Val Leu Ala Lys Asn Pro Lys Gly Lys Asp Ile
    770                 775                 780                 
Glu Asp Gly Asp Lys Phe Ile Cys Asn Asp Asp Phe Lys His Lys Leu
785                 790                 795                 800 
Phe Arg Ile Lys Ile Asn Gln Ile Gln Met Lys Glu Thr Val Glu Glu
                805                 810                 815     
Gln Ala Ser Thr Thr Glu Arg Val Phe Gln Asp Arg Gln Tyr Gln Ile
            820                 825                 830         
Asp Ala Ala Ile Val Arg Ile Met Lys Met Arg Lys Thr Leu Ser His
        835                 840                 845             
Asn Leu Leu Val Ser Glu Val Tyr Asn Gln Leu Lys Phe Pro Val Lys
    850                 855                 860                 
Pro Ala Asp Leu Lys Lys Arg Ile Glu Ser Leu Ile Asp Arg Asp Tyr
865                 870                 875                 880 
Met Glu Arg Asp Lys Glu Asn Pro Asn Gln Tyr Asn Tyr Ile Ala
                885                 890                 895 


<210> 6055
<211> 913
<212> PRT
<213> Homo sapiens

<400> 6055
Met Met Ser Gln Ser Ser Gly Ser Gly Asp Gly Asn Asp Asp Glu Ala
 1               5                  10                  15      
Thr Thr Ser Lys Asp Gly Gly Phe Ser Ser Pro Ser Pro Ser Ala Ala
            20                  25                  30          
Ala Ala Ala Gln Glu Val Arg Ser Ala Thr Asp Gly Asn Thr Ser Thr
        35                  40                  45              
Thr Pro Pro Thr Ser Ala Lys Lys Arg Lys Leu Asn Ser Ser Ser Ser
    50                  55                  60                  
Ser Ser Ser Asn Ser Ser Asn Glu Arg Glu Asp Phe Asp Ser Thr Ser
65                  70                  75                  80  
Ser Ser Ser Ser Thr Pro Pro Leu Gln Pro Arg Asp Ser Ala Ser Pro
                85                  90                  95      
Ser Thr Ser Ser Phe Cys Leu Gly Val Ser Val Ala Ala Ser Ser His
            100                 105                 110         
Val Pro Ile Gln Lys Lys Leu Arg Phe Glu Asp Thr Leu Glu Phe Val
        115                 120                 125             
Gly Phe Asp Ala Lys Met Ala Glu Glu Ser Ser Ser Ser Ser Ser Ser
    130                 135                 140                 
Ser Ser Pro Thr Ala Ala Thr Ser Gln Gln Gln Gln Leu Lys Asn Lys
145                 150                 155                 160 
Ser Ile Leu Ile Ser Ser Val Ala Ser Val His His Ala Asn Gly Leu
                165                 170                 175     
Ala Lys Ser Ser Thr Thr Val Ser Ser Phe Ala Asn Ser Lys Pro Gly
            180                 185                 190         
Ser Ala Lys Lys Leu Val Ile Lys Asn Phe Lys Asp Lys Pro Lys Leu
        195                 200                 205             
Pro Glu Asn Tyr Thr Asp Glu Thr Trp Gln Lys Leu Lys Glu Ala Val
    210                 215                 220                 
Glu Ala Ile Gln Asn Ser Thr Ser Ile Lys Tyr Asn Leu Glu Glu Leu
225                 230                 235                 240 
Tyr Gln Ala Val Glu Asn Leu Cys Ser Tyr Lys Ile Ser Ala Asn Leu
                245                 250                 255     
Tyr Lys Gln Leu Arg Gln Ile Cys Glu Asp His Ile Lys Ala Gln Ile
            260                 265                 270         
His Gln Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu Lys Lys
        275                 280                 285             
Ile Asp Arg Cys Trp Gln Asn His Cys Arg Gln Met Ile Met Ile Arg
    290                 295                 300                 
Ser Ile Phe Leu Phe Leu Asp Arg Thr Tyr Val Leu Gln Asn Ser Met
305                 310                 315                 320 
Leu Pro Ser Ile Trp Asp Met Gly Leu Glu Leu Phe Arg Ala His Ile
                325                 330                 335     
Ile Ser Asp Gln Lys Val Gln Asn Lys Thr Ile Asp Gly Ile Leu Leu
            340                 345                 350         
Leu Ile Glu Arg Glu Arg Asn Gly Glu Ala Ile Asp Arg Ser Leu Leu
        355                 360                 365             
Arg Ser Leu Leu Ser Met Leu Ser Asp Leu Gln Ile Tyr Gln Asp Ser
    370                 375                 380                 
Phe Glu Gln Arg Phe Leu Glu Glu Thr Asn Arg Leu Tyr Ala Ala Glu
385                 390                 395                 400 
Gly Gln Lys Leu Met Gln Glu Arg Glu Val Pro Glu Tyr Leu His His
                405                 410                 415     
Val Asn Lys Arg Leu Glu Glu Glu Ala Asp Arg Leu Ile Thr Tyr Leu
            420                 425                 430         
Asp Gln Thr Thr Gln Lys Ser Leu Ile Ala Thr Val Glu Lys Gln Leu
        435                 440                 445             
Leu Gly Glu His Leu Thr Ala Ile Leu Gln Lys Gly Leu Asn Asn Leu
    450                 455                 460                 
Leu Asp Glu Asn Arg Ile Gln Asp Leu Ser Leu Leu Tyr Gln Leu Phe
465                 470                 475                 480 
Ser Arg Val Arg Gly Gly Val Gln Val Leu Leu Gln Gln Trp Ile Glu
                485                 490                 495     
Tyr Ile Lys Ala Phe Gly Ser Thr Ile Val Ile Asn Pro Glu Lys Asp
            500                 505                 510         
Lys Thr Met Val Gln Glu Leu Leu Asp Phe Lys Asp Lys Val Asp His
        515                 520                 525             
Ile Ile Asp Ile Cys Phe Leu Lys Asn Glu Lys Phe Ile Asn Ala Met
    530                 535                 540                 
Lys Glu Ala Phe Glu Thr Phe Ile Asn Lys Arg Pro Asn Lys Pro Ala
545                 550                 555                 560 
Glu Leu Ile Ala Lys Tyr Val Asp Ser Lys Leu Arg Ala Gly Asn Lys
                565                 570                 575     
Glu Ala Thr Asp Glu Glu Leu Glu Lys Met Leu Asp Lys Ile Met Ile
            580                 585                 590         
Ile Phe Arg Phe Ile Tyr Gly Lys Asp Val Phe Glu Ala Phe Tyr Lys
        595                 600                 605             
Lys Asp Leu Ala Lys Arg Leu Leu Val Gly Lys Ser Ala Ser Val Asp
    610                 615                 620                 
Ala Glu Lys Ser Met Leu Ser Lys Leu Lys His Glu Cys Gly Ala Ala
625                 630                 635                 640 
Phe Thr Ser Lys Leu Glu Gly Met Phe Lys Asp Met Glu Leu Ser Lys
                645                 650                 655     
Asp Ile Met Ile Gln Phe Lys Gln Tyr Met Gln Asn Gln Asn Val Pro
            660                 665                 670         
Gly Asn Ile Glu Leu Thr Val Asn Ile Leu Thr Met Gly Tyr Trp Pro
        675                 680                 685             
Thr Tyr Val Pro Met Glu Val His Leu Pro Pro Glu Met Val Lys Leu
    690                 695                 700                 
Gln Glu Ile Phe Lys Thr Phe Tyr Leu Gly Lys His Ser Gly Arg Lys
705                 710                 715                 720 
Leu Gln Trp Gln Ser Thr Ile Gly His Cys Val Leu Lys Ala Glu Phe
                725                 730                 735     
Lys Glu Gly Lys Lys Glu Leu Gln Val Ser Leu Phe Gln Thr Leu Val
            740                 745                 750         
Leu Leu Met Phe Asn Glu Gly Glu Glu Phe Ser Leu Glu Glu Ile Lys
        755                 760                 765             
Gln Ala Thr Gly Ile Glu Asp Gly Glu Leu Arg Arg Thr Leu Gln Ser
    770                 775                 780                 
Leu Ala Cys Gly Lys Ala Arg Val Leu Ala Lys Asn Pro Lys Gly Lys
785                 790                 795                 800 
Asp Ile Glu Asp Gly Asp Lys Phe Ile Cys Asn Asp Asp Phe Lys His
                805                 810                 815     
Lys Leu Phe Arg Ile Lys Ile Asn Gln Ile Gln Met Lys Glu Thr Val
            820                 825                 830         
Glu Glu Gln Ala Ser Thr Thr Glu Arg Val Phe Gln Asp Arg Gln Tyr
        835                 840                 845             
Gln Ile Asp Ala Ala Ile Val Arg Ile Met Lys Met Arg Lys Thr Leu
    850                 855                 860                 
Ser His Asn Leu Leu Val Ser Glu Val Tyr Asn Gln Leu Lys Phe Pro
865                 870                 875                 880 
Val Lys Pro Ala Asp Leu Lys Lys Arg Ile Glu Ser Leu Ile Asp Arg
                885                 890                 895     
Asp Tyr Met Glu Arg Asp Lys Glu Asn Pro Asn Gln Tyr Asn Tyr Ile
            900                 905                 910         
Ala
    


<210> 6056
<211> 5395
<212> PRT
<213> Homo sapiens

<400> 6056
Met Phe Pro Val Leu Trp Ala Gly Ile Pro Gly Arg Asp Val Gly Ser
 1               5                  10                  15      
Leu Gln Pro Leu Pro Pro Gly Phe Lys Gln Phe Cys Thr Ser Ala Ser
            20                  25                  30          
Arg Val Ala Val Ile Ala Asp Glu Arg Asp Arg Val Gln Lys Lys Thr
        35                  40                  45              
Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg Lys His Ile
    50                  55                  60                  
Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu
65                  70                  75                  80  
Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys Gly Arg Met
                85                  90                  95      
Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Phe Leu Lys
            100                 105                 110         
Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp
        115                 120                 125             
Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His
    130                 135                 140                 
Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly Asp Met Ser
145                 150                 155                 160 
Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr Ala Gly Tyr
                165                 170                 175     
Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser Asp Gly Lys
            180                 185                 190         
Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu Val Asp Met
        195                 200                 205             
Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu Gln Ala Phe
    210                 215                 220                 
Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp Ala Glu Asp
225                 230                 235                 240 
Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser
                245                 250                 255     
Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile
            260                 265                 270         
Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln Ser Arg Val
        275                 280                 285             
Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu Met Ser Asp
    290                 295                 300                 
Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln
305                 310                 315                 320 
Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu Arg Glu Lys
                325                 330                 335     
Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp Ile Glu Phe
            340                 345                 350         
Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp Val Glu Glu
        355                 360                 365             
Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu Lys Ser Leu
    370                 375                 380                 
Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile Ala Asn Lys
385                 390                 395                 400 
Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr Leu Ala Lys
                405                 410                 415     
Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly Gln Pro Val
            420                 425                 430         
Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys Glu Gly Leu
        435                 440                 445             
Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp Glu Asn Tyr
    450                 455                 460                 
Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu Gln Asp Glu
465                 470                 475                 480 
Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg Lys Gly His
                485                 490                 495     
Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr Thr Thr His
            500                 505                 510         
Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser Ser Thr Ser
        515                 520                 525             
Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala Ile Ser Ser
    530                 535                 540                 
Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu Leu Ser Trp
545                 550                 555                 560 
Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp Gly Asn Asp
                565                 570                 575     
Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His Ile His Thr
            580                 585                 590         
Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg Leu Tyr Glu
        595                 600                 605             
Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu Thr Leu Gly
    610                 615                 620                 
Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser Ser Phe Arg
625                 630                 635                 640 
Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg Ala Thr Ala
                645                 650                 655     
Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu Ala Tyr Asp
            660                 665                 670         
Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn Tyr Phe Ser
        675                 680                 685             
Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe Arg Ser Leu
    690                 695                 700                 
Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro Ala Lys Gln
705                 710                 715                 720 
Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu Gln Trp Met
                725                 730                 735     
Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu Asn Thr Ala
            740                 745                 750         
Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser Phe Leu Arg
        755                 760                 765             
Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp His Asn Thr
    770                 775                 780                 
Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met Asp Glu Lys
785                 790                 795                 800 
Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu Val Gly Arg
                805                 810                 815     
Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp His Val Leu
            820                 825                 830         
Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg Gln Ile Glu
        835                 840                 845             
Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp Asn Ser Gln
    850                 855                 860                 
Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val
865                 870                 875                 880 
Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp Ala Ile Glu
                885                 890                 895     
Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met Ala Leu Trp
            900                 905                 910         
His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp Asn Tyr Leu
        915                 920                 925             
Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu Lys Leu Arg
    930                 935                 940                 
Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn Leu Gln Ala
945                 950                 955                 960 
His Tyr Glu Asp Phe Leu Gln Asp Ser Arg Asp Ser Val Leu Phe Ser
                965                 970                 975     
Val Ala Asp Arg Leu Arg Leu Glu Glu Glu Val Glu Ala Cys Lys Ala
            980                 985                 990         
Arg Phe Gln His Leu Met Lys Ser Met Glu Asn Glu Asp Lys Glu Glu
        995                 1000                1005            
Thr Val Ala Lys Met Tyr Ile Ser Glu Leu Lys Asn Ile Arg Leu Arg
    1010                1015                1020                
Leu Glu Glu Tyr Glu Gln Arg Val Val Lys Arg Ile Gln Ser Leu Ala
1025                1030                1035                1040
Ser Ser Arg Thr Asp Arg Asp Ala Trp Gln Asp Asn Ala Leu Arg Ile
                1045                1050                1055    
Ala Glu Gln Glu His Thr Gln Glu Asp Leu Gln Gln Leu Arg Ser Asp
            1060                1065                1070        
Leu Asp Ala Val Ser Met Lys Cys Asp Ser Phe Leu His Gln Ser Pro
        1075                1080                1085            
Ser Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Leu Leu Val
    1090                1095                1100                
Glu Lys Met Asp His Val Tyr Gly Leu Ser Thr Val Tyr Leu Asn Lys
1105                1110                1115                1120
Leu Lys Thr Val Asp Val Ile Val Arg Ser Ile Gln Asp Ala Glu Leu
                1125                1130                1135    
Leu Val Lys Gly Tyr Glu Ile Lys Leu Ser Gln Glu Glu Val Val Leu
            1140                1145                1150        
Ala Asp Leu Ser Ala Leu Glu Ala His Trp Ser Thr Leu Arg His Trp
        1155                1160                1165            
Leu Ser Asp Val Lys Asp Lys Asn Ser Val Phe Ser Val Leu Asp Glu
    1170                1175                1180                
Glu Ile Ala Lys Ala Lys Val Val Ala Glu Gln Met Ser Arg Leu Thr
1185                1190                1195                1200
Pro Glu Arg Asn Leu Asp Leu Glu Arg Tyr Gln Glu Lys Gly Ser Gln
                1205                1210                1215    
Leu Gln Glu Arg Trp His Arg Val Ile Ala Gln Leu Glu Ile Arg Gln
            1220                1225                1230        
Ser Glu Leu Glu Ser Ile Gln Glu Val Leu Gly Asp Tyr Arg Ala Cys
        1235                1240                1245            
His Gly Thr Leu Ile Lys Trp Ile Glu Glu Thr Thr Ala Gln Gln Glu
    1250                1255                1260                
Met Met Lys Pro Gly Gln Ala Glu Asp Ser Arg Val Leu Ser Glu Gln
1265                1270                1275                1280
Leu Ser Gln Gln Thr Ala Leu Phe Ala Glu Ile Glu Arg Asn Gln Thr
                1285                1290                1295    
Lys Leu Asp Gln Cys Gln Lys Phe Ser Gln Gln Tyr Ser Thr Ile Val
            1300                1305                1310        
Lys Asp Tyr Glu Leu Gln Leu Met Thr Tyr Lys Ala Phe Val Glu Ser
        1315                1320                1325            
Gln Gln Lys Ser Pro Gly Lys Arg Arg Arg Met Leu Ser Ser Ser Asp
    1330                1335                1340                
Ala Ile Thr Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu
1345                1350                1355                1360
Val Thr Leu Thr Thr Gln His Val Lys Tyr Ile Ser Asp Ala Leu Arg
                1365                1370                1375    
Arg Leu Glu Glu Glu Glu Lys Val Val Glu Glu Glu Lys Gln Glu His
            1380                1385                1390        
Val Glu Lys Val Lys Glu Leu Leu Gly Trp Val Ser Thr Leu Ala Arg
        1395                1400                1405            
Asn Thr Gln Gly Lys Ala Thr Ser Ser Glu Thr Lys Glu Ser Thr Asp
    1410                1415                1420                
Ile Glu Lys Ala Ile Leu Glu Gln Gln Val Leu Ser Glu Glu Leu Thr
1425                1430                1435                1440
Thr Lys Lys Glu Gln Val Ser Glu Ala Ile Lys Ala Ser Gln Ile Phe
                1445                1450                1455    
Leu Ala Lys His Gly His Lys Leu Ser Glu Lys Glu Lys Lys Gln Ile
            1460                1465                1470        
Ser Glu Gln Leu Asn Ala Leu Asn Lys Ala Tyr His Asp Leu Cys Asp
        1475                1480                1485            
Gly Ser Ala Asn Gln Leu Gln Gln Leu Gln Ser Gln Leu Ala His Gln
    1490                1495                1500                
Thr Glu Gln Lys Thr Leu Gln Lys Gln Gln Asn Thr Cys His Gln Gln
1505                1510                1515                1520
Leu Glu Asp Leu Cys Ser Trp Val Gly Gln Ala Glu Arg Ala Leu Ala
                1525                1530                1535    
Gly His Gln Gly Arg Thr Thr Gln Gln Asp Leu Ser Ala Leu Gln Lys
            1540                1545                1550        
Asn Gln Ser Asp Leu Lys Asp Leu Gln Asp Asp Ile Gln Asn Arg Ala
        1555                1560                1565            
Thr Ser Phe Ala Thr Val Val Lys Asp Ile Glu Gly Phe Met Glu Glu
    1570                1575                1580                
Asn Gln Thr Lys Leu Ser Pro Arg Glu Leu Thr Ala Leu Arg Glu Lys
1585                1590                1595                1600
Leu His Gln Ala Lys Glu Gln Tyr Glu Ala Leu Gln Glu Glu Thr Arg
                1605                1610                1615    
Val Ala Gln Lys Glu Leu Glu Glu Ala Val Thr Ser Ala Leu Gln Gln
            1620                1625                1630        
Glu Thr Glu Lys Ser Lys Ala Ala Lys Glu Leu Ala Glu Asn Lys Lys
        1635                1640                1645            
Lys Ile Asp Ala Leu Leu Asp Trp Val Thr Ser Val Gly Ser Ser Gly
    1650                1655                1660                
Gly Gln Leu Leu Thr Asn Leu Pro Gly Met Glu Gln Leu Ser Gly Ala
1665                1670                1675                1680
Ser Leu Glu Lys Gly Ala Leu Asp Thr Thr Asp Gly Tyr Met Gly Val
                1685                1690                1695    
Asn Gln Ala Pro Glu Lys Leu Asp Lys Gln Cys Glu Met Met Lys Ala
            1700                1705                1710        
Arg His Gln Glu Leu Leu Ser Gln Gln Gln Asn Phe Ile Leu Ala Thr
        1715                1720                1725            
Gln Ser Ala Gln Ala Phe Leu Asp Gln His Gly His Asn Leu Thr Pro
    1730                1735                1740                
Glu Glu Gln Gln Met Leu Gln Gln Lys Leu Gly Glu Leu Lys Glu Gln
1745                1750                1755                1760
Tyr Ser Thr Ser Leu Ala Gln Ser Glu Ala Glu Leu Lys Gln Val Gln
                1765                1770                1775    
Thr Leu Gln Asp Glu Leu Gln Lys Phe Leu Gln Asp His Lys Glu Phe
            1780                1785                1790        
Glu Ser Trp Leu Glu Arg Ser Glu Lys Glu Leu Glu Asn Met His Lys
        1795                1800                1805            
Gly Gly Ser Ser Pro Glu Thr Leu Pro Ser Leu Leu Lys Arg Gln Gly
    1810                1815                1820                
Ser Phe Ser Glu Asp Val Ile Ser His Lys Gly Asp Leu Arg Phe Val
1825                1830                1835                1840
Thr Ile Ser Gly Gln Lys Val Leu Asp Met Glu Asn Ser Phe Lys Glu
                1845                1850                1855    
Gly Lys Glu Pro Ser Glu Ile Gly Asn Leu Val Lys Asp Lys Leu Lys
            1860                1865                1870        
Asp Ala Thr Glu Arg Tyr Thr Ala Leu His Ser Lys Cys Thr Arg Leu
        1875                1880                1885            
Gly Ser His Leu Asn Met Leu Leu Gly Gln Tyr His Gln Phe Gln Asn
    1890                1895                1900                
Ser Ala Asp Ser Leu Gln Ala Trp Met Gln Ala Cys Glu Ala Asn Val
1905                1910                1915                1920
Glu Lys Leu Leu Ser Asp Thr Val Ala Ser Asp Pro Gly Val Leu Gln
                1925                1930                1935    
Glu Gln Leu Ala Thr Thr Lys Gln Leu Gln Glu Glu Leu Ala Glu His
            1940                1945                1950        
Gln Val Pro Val Glu Lys Leu Gln Lys Val Ala Arg Asp Ile Met Glu
        1955                1960                1965            
Ile Glu Gly Glu Pro Ala Pro Asp His Arg His Val Gln Glu Thr Thr
    1970                1975                1980                
Asp Ser Ile Leu Ser His Phe Gln Ser Leu Ser Tyr Ser Leu Ala Glu
1985                1990                1995                2000
Arg Ser Ser Leu Leu Gln Lys Ala Ile Ala Gln Ser Gln Ser Val Gln
                2005                2010                2015    
Glu Ser Leu Glu Ser Leu Leu Gln Ser Ile Gly Glu Val Glu Gln Asn
            2020                2025                2030        
Leu Glu Gly Lys Gln Val Ser Ser Leu Ser Ser Gly Val Ile Gln Glu
        2035                2040                2045            
Ala Leu Ala Thr Asn Met Lys Leu Lys Gln Asp Ile Ala Arg Gln Lys
    2050                2055                2060                
Ser Ser Leu Glu Ala Thr Arg Glu Met Val Thr Arg Phe Met Glu Thr
2065                2070                2075                2080
Ala Asp Ser Thr Thr Ala Ala Val Leu Gln Gly Lys Leu Ala Glu Val
                2085                2090                2095    
Ser Gln Arg Phe Glu Gln Leu Cys Leu Gln Gln Gln Glu Lys Glu Ser
            2100                2105                2110        
Ser Leu Lys Lys Leu Leu Pro Gln Ala Glu Met Phe Glu His Leu Ser
        2115                2120                2125            
Gly Lys Leu Gln Gln Phe Met Glu Asn Lys Ser Arg Met Leu Ala Ser
    2130                2135                2140                
Gly Asn Gln Pro Asp Gln Asp Ile Thr His Phe Phe Gln Gln Ile Gln
2145                2150                2155                2160
Glu Leu Asn Leu Glu Met Glu Asp Gln Gln Glu Asn Leu Asp Thr Leu
                2165                2170                2175    
Glu His Leu Val Thr Glu Leu Ser Ser Cys Gly Phe Ala Leu Asp Leu
            2180                2185                2190        
Cys Gln His Gln Asp Arg Val Gln Asn Leu Arg Lys Asp Phe Thr Glu
        2195                2200                2205            
Leu Gln Lys Thr Val Lys Glu Arg Glu Lys Asp Ala Ser Ser Cys Gln
    2210                2215                2220                
Glu Gln Leu Asp Glu Phe Arg Lys Leu Val Arg Thr Phe Gln Lys Trp
2225                2230                2235                2240
Leu Lys Glu Thr Glu Gly Ser Ile Pro Pro Thr Glu Thr Ser Met Ser
                2245                2250                2255    
Ala Lys Glu Leu Glu Lys Gln Ile Glu His Leu Lys Ser Leu Leu Asp
            2260                2265                2270        
Asp Trp Ala Ser Lys Gly Thr Leu Val Glu Glu Ile Asn Cys Lys Gly
        2275                2280                2285            
Thr Ser Leu Glu Asn Leu Ile Met Glu Ile Thr Ala Pro Asp Ser Gln
    2290                2295                2300                
Gly Lys Thr Gly Ser Ile Leu Pro Ser Val Gly Ser Ser Val Gly Ser
2305                2310                2315                2320
Val Asn Gly Tyr His Thr Cys Lys Asp Leu Thr Glu Ile Gln Cys Asp
                2325                2330                2335    
Met Ser Asp Val Asn Leu Lys Tyr Glu Lys Leu Gly Gly Val Leu His
            2340                2345                2350        
Glu Arg Gln Glu Ser Leu Gln Ala Ile Leu Asn Arg Met Glu Glu Val
        2355                2360                2365            
His Lys Glu Ala Asn Ser Val Leu Gln Trp Leu Glu Ser Lys Glu Glu
    2370                2375                2380                
Val Leu Lys Ser Met Asp Ala Met Ser Ser Pro Thr Lys Thr Glu Thr
2385                2390                2395                2400
Val Lys Ala Gln Ala Glu Ser Asn Lys Ala Phe Leu Ala Glu Leu Glu
                2405                2410                2415    
Gln Asn Ser Pro Lys Ile Gln Lys Val Lys Glu Ala Leu Ala Gly Leu
            2420                2425                2430        
Leu Val Thr Tyr Pro Asn Ser Gln Glu Ala Glu Asn Trp Lys Lys Ile
        2435                2440                2445            
Gln Glu Glu Leu Asn Ser Arg Trp Glu Arg Ala Thr Glu Val Thr Val
    2450                2455                2460                
Ala Arg Gln Arg Gln Leu Glu Glu Ser Ala Ser His Leu Ala Cys Phe
2465                2470                2475                2480
Gln Ala Ala Glu Ser Gln Leu Gln Pro Trp Leu Met Glu Lys Glu Leu
                2485                2490                2495    
Met Met Gly Val Leu Gly Pro Leu Ser Ile Asp Pro Asn Met Leu Asn
            2500                2505                2510        
Ala Gln Lys Gln Gln Val Gln Phe Met Leu Lys Glu Phe Glu Ala Arg
        2515                2520                2525            
Arg Gln Gln His Glu Gln Leu Asn Glu Ala Ala Gln Gly Ile Leu Thr
    2530                2535                2540                
Gly Pro Gly Asp Val Ser Leu Ser Thr Ser Gln Val Gln Lys Glu Leu
2545                2550                2555                2560
Gln Ser Ile Asn Gln Lys Trp Val Glu Leu Thr Asp Lys Leu Asn Ser
                2565                2570                2575    
Arg Ser Ser Gln Ile Asp Gln Ala Ile Val Lys Ser Thr Gln Tyr Gln
            2580                2585                2590        
Glu Leu Leu Gln Asp Leu Ser Glu Lys Val Arg Ala Val Gly Gln Arg
        2595                2600                2605            
Leu Ser Val Gln Ser Ala Ile Ser Thr Gln Pro Glu Ala Val Lys Gln
    2610                2615                2620                
Gln Leu Glu Glu Thr Ser Glu Ile Arg Ser Asp Leu Glu Gln Leu Asp
2625                2630                2635                2640
His Glu Val Lys Glu Ala Gln Thr Leu Cys Asp Glu Leu Ser Val Leu
                2645                2650                2655    
Ile Gly Glu Gln Tyr Leu Lys Asp Glu Leu Lys Lys Arg Leu Glu Thr
            2660                2665                2670        
Val Ala Leu Pro Leu Gln Gly Leu Glu Asp Leu Ala Ala Asp Arg Ile
        2675                2680                2685            
Asn Arg Leu Gln Ala Ala Leu Ala Ser Thr Gln Gln Phe Gln Gln Met
    2690                2695                2700                
Phe Asp Glu Leu Arg Thr Trp Leu Asp Asp Lys Gln Ser Gln Gln Ala
2705                2710                2715                2720
Lys Asn Cys Pro Ile Ser Ala Lys Leu Glu Arg Leu Gln Ser Gln Leu
                2725                2730                2735    
Gln Glu Asn Glu Glu Phe Gln Lys Ser Leu Asn Gln His Ser Gly Ser
            2740                2745                2750        
Tyr Glu Val Ile Val Ala Glu Gly Glu Ser Leu Leu Leu Ser Val Pro
        2755                2760                2765            
Pro Gly Glu Glu Lys Arg Thr Leu Gln Asn Gln Leu Val Glu Leu Lys
    2770                2775                2780                
Asn His Trp Glu Glu Leu Ser Lys Lys Thr Ala Asp Arg Gln Ser Arg
2785                2790                2795                2800
Leu Lys Asp Cys Met Gln Lys Ala Gln Lys Tyr Gln Trp His Val Glu
                2805                2810                2815    
Asp Leu Val Pro Trp Ile Glu Asp Cys Lys Ala Lys Met Ser Glu Leu
            2820                2825                2830        
Arg Val Thr Leu Asp Pro Val Gln Leu Glu Ser Ser Leu Leu Arg Ser
        2835                2840                2845            
Lys Ala Met Leu Asn Glu Val Glu Lys Arg Arg Ser Leu Leu Glu Ile
    2850                2855                2860                
Leu Asn Ser Ala Ala Asp Ile Leu Ile Asn Ser Ser Glu Ala Asp Glu
2865                2870                2875                2880
Asp Gly Ile Arg Asp Glu Lys Ala Gly Ile Asn Gln Asn Met Asp Ala
                2885                2890                2895    
Val Thr Glu Glu Leu Gln Ala Lys Thr Gly Ser Leu Glu Glu Met Thr
            2900                2905                2910        
Gln Arg Leu Arg Glu Phe Gln Glu Ser Phe Lys Asn Ile Glu Lys Lys
        2915                2920                2925            
Val Glu Gly Ala Lys His Gln Leu Glu Ile Phe Asp Ala Leu Gly Ser
    2930                2935                2940                
Gln Ala Cys Ser Asn Lys Asn Leu Glu Lys Leu Arg Ala Gln Gln Glu
2945                2950                2955                2960
Val Leu Gln Ala Leu Glu Pro Gln Val Asp Tyr Leu Arg Asn Phe Thr
                2965                2970                2975    
Gln Gly Leu Val Glu Asp Ala Pro Asp Gly Ser Asp Ala Ser Gln Leu
            2980                2985                2990        
Leu His Gln Ala Glu Val Ala Gln Gln Glu Phe Leu Glu Val Lys Gln
        2995                3000                3005            
Arg Val Asn Ser Gly Cys Val Met Met Glu Asn Lys Leu Glu Gly Ile
    3010                3015                3020                
Gly Gln Phe His Cys Arg Val Arg Glu Met Phe Ser Gln Leu Ala Asp
3025                3030                3035                3040
Leu Asp Asp Glu Leu Asp Gly Met Gly Ala Ile Gly Arg Asp Thr Asp
                3045                3050                3055    
Ser Leu Gln Ser Gln Ile Glu Asp Val Arg Leu Phe Leu Asn Lys Ile
            3060                3065                3070        
His Val Leu Lys Leu Asp Ile Glu Ala Ser Glu Ala Glu Cys Arg His
        3075                3080                3085            
Met Leu Glu Glu Glu Gly Thr Leu Asp Leu Leu Gly Leu Lys Arg Glu
    3090                3095                3100                
Leu Glu Ala Leu Asn Lys Gln Cys Gly Lys Leu Thr Glu Arg Gly Lys
3105                3110                3115                3120
Ala Arg Gln Glu Gln Leu Glu Leu Thr Leu Gly Arg Val Glu Asp Phe
                3125                3130                3135    
Tyr Arg Lys Leu Lys Gly Leu Asn Asp Ala Thr Thr Ala Ala Glu Glu
            3140                3145                3150        
Ala Glu Ala Leu Gln Trp Val Val Gly Thr Glu Val Glu Ile Ile Asn
        3155                3160                3165            
Gln Gln Leu Ala Asp Phe Lys Met Phe Gln Lys Glu Gln Val Asp Pro
    3170                3175                3180                
Leu Gln Met Lys Leu Gln Gln Val Asn Gly Leu Gly Gln Gly Leu Ile
3185                3190                3195                3200
Gln Ser Ala Gly Lys Asp Cys Asp Val Gln Gly Leu Glu His Asp Met
                3205                3210                3215    
Glu Glu Ile Asn Ala Arg Trp Asn Thr Leu Asn Lys Lys Val Ala Gln
            3220                3225                3230        
Arg Ile Ala Gln Leu Gln Glu Ala Leu Leu His Cys Gly Lys Phe Gln
        3235                3240                3245            
Asp Ala Leu Glu Pro Leu Leu Ser Trp Leu Ala Asp Thr Glu Glu Leu
    3250                3255                3260                
Ile Ala Asn Gln Lys Pro Pro Ser Ala Glu Tyr Lys Val Val Lys Ala
3265                3270                3275                3280
Gln Ile Gln Glu Gln Lys Leu Leu Gln Arg Leu Leu Asp Asp Arg Lys
                3285                3290                3295    
Ala Thr Val Asp Met Leu Gln Ala Glu Gly Gly Arg Ile Ala Gln Ser
            3300                3305                3310        
Ala Glu Leu Ala Asp Arg Glu Lys Ile Thr Gly Gln Leu Glu Ser Leu
        3315                3320                3325            
Glu Ser Arg Trp Thr Glu Leu Leu Ser Lys Ala Ala Ala Arg Gln Lys
    3330                3335                3340                
Gln Leu Glu Asp Ile Leu Val Leu Ala Lys Gln Phe His Glu Thr Ala
3345                3350                3355                3360
Glu Pro Ile Ser Asp Phe Leu Ser Val Thr Glu Lys Lys Leu Ala Asn
                3365                3370                3375    
Ser Glu Pro Val Gly Thr Gln Thr Ala Lys Ile Gln Gln Gln Ile Ile
            3380                3385                3390        
Arg His Lys Ala Leu Glu Glu Asp Ile Glu Asn His Ala Thr Asp Val
        3395                3400                3405            
His Gln Ala Val Lys Ile Gly Gln Ser Leu Ser Ser Leu Thr Ser Pro
    3410                3415                3420                
Ala Glu Gln Gly Val Leu Ser Glu Lys Ile Asp Ser Leu Gln Ala Arg
3425                3430                3435                3440
Tyr Ser Glu Ile Gln Asp Arg Cys Cys Arg Lys Ala Ala Leu Leu Asp
                3445                3450                3455    
Gln Ala Leu Ser Asn Ala Arg Leu Phe Gly Glu Asp Glu Val Glu Val
            3460                3465                3470        
Leu Asn Trp Leu Ala Glu Val Glu Asp Lys Leu Ser Ser Val Phe Val
        3475                3480                3485            
Lys Asp Phe Lys Gln Asp Val Leu His Arg Gln His Ala Asp His Leu
    3490                3495                3500                
Ala Leu Asn Glu Glu Ile Val Asn Arg Lys Lys Asn Val Asp Gln Ala
3505                3510                3515                3520
Ile Lys Asn Gly Gln Ala Leu Leu Lys Gln Thr Thr Gly Glu Glu Val
                3525                3530                3535    
Leu Leu Ile Gln Glu Lys Leu Asp Gly Ile Lys Thr Arg Tyr Ala Asp
            3540                3545                3550        
Ile Thr Val Thr Ser Ser Lys Ala Leu Arg Thr Leu Glu Gln Ala Arg
        3555                3560                3565            
Gln Leu Ala Thr Lys Phe Gln Ser Thr Tyr Glu Glu Leu Thr Gly Trp
    3570                3575                3580                
Leu Arg Glu Val Glu Glu Glu Leu Ala Thr Ser Gly Gly Gln Ser Pro
3585                3590                3595                3600
Thr Gly Glu Gln Ile Pro Gln Phe Gln Gln Arg Gln Lys Glu Leu Lys
                3605                3610                3615    
Lys Glu Val Met Glu His Arg Leu Val Leu Asp Thr Val Asn Glu Val
            3620                3625                3630        
Ser Arg Ala Leu Leu Glu Leu Val Pro Trp Arg Ala Arg Glu Gly Leu
        3635                3640                3645            
Asp Lys Leu Val Ser Asp Ala Asn Glu Gln Tyr Lys Leu Val Ser Asp
    3650                3655                3660                
Thr Ile Gly Gln Arg Val Asp Glu Ile Asp Ala Ala Ile Gln Arg Ser
3665                3670                3675                3680
Gln Gln Tyr Glu Gln Ala Ala Asp Ala Glu Leu Ala Trp Val Ala Glu
                3685                3690                3695    
Thr Lys Arg Lys Leu Met Ala Leu Gly Pro Ile Arg Leu Glu Gln Asp
            3700                3705                3710        
Gln Thr Thr Ala Gln Leu Gln Val Gln Lys Ala Phe Ser Ile Asp Ile
        3715                3720                3725            
Ile Arg His Lys Asp Ser Met Asp Glu Leu Phe Ser His Arg Ser Glu
    3730                3735                3740                
Ile Phe Gly Thr Cys Gly Glu Glu Gln Lys Thr Val Leu Gln Glu Lys
3745                3750                3755                3760
Thr Glu Ser Leu Ile Gln Gln Tyr Glu Ala Ile Ser Leu Leu Asn Ser
                3765                3770                3775    
Glu Arg Tyr Ala Arg Leu Glu Arg Ala Gln Val Leu Val Asn Gln Phe
            3780                3785                3790        
Trp Glu Thr Tyr Glu Glu Leu Ser Pro Trp Ile Glu Glu Thr Arg Ala
        3795                3800                3805            
Leu Ile Ala Gln Leu Pro Ser Pro Ala Ile Asp His Glu Gln Leu Arg
    3810                3815                3820                
Gln Gln Gln Glu Glu Met Arg Gln Leu Arg Glu Ser Ile Ala Glu His
3825                3830                3835                3840
Lys Pro His Ile Asp Lys Leu Leu Lys Ile Gly Pro Gln Leu Lys Glu
                3845                3850                3855    
Leu Asn Pro Glu Glu Gly Glu Met Val Glu Glu Lys Tyr Gln Lys Ala
            3860                3865                3870        
Glu Asn Met Tyr Ala Gln Ile Lys Glu Glu Val Arg Gln Arg Ala Leu
        3875                3880                3885            
Ala Leu Asp Glu Ala Val Ser Gln Ser Thr Gln Ile Thr Glu Phe His
    3890                3895                3900                
Asp Lys Ile Glu Pro Met Leu Glu Thr Leu Glu Asn Leu Ser Ser Arg
3905                3910                3915                3920
Leu Arg Met Pro Pro Leu Ile Pro Ala Glu Val Asp Lys Ile Arg Glu
                3925                3930                3935    
Cys Ile Ser Asp Asn Lys Ser Ala Thr Val Glu Leu Glu Lys Leu Gln
            3940                3945                3950        
Pro Ser Phe Glu Ala Leu Lys Arg Arg Gly Glu Glu Leu Ile Gly Arg
        3955                3960                3965            
Ser Gln Gly Ala Asp Lys Asp Leu Ala Ala Lys Glu Ile Gln Asp Lys
    3970                3975                3980                
Leu Asp Gln Met Val Phe Phe Trp Glu Asp Ile Lys Ala Arg Ala Glu
3985                3990                3995                4000
Glu Arg Glu Ile Lys Phe Leu Asp Val Leu Glu Leu Ala Glu Lys Phe
                4005                4010                4015    
Trp Tyr Asp Met Ala Ala Leu Leu Thr Thr Ile Lys Asp Thr Gln Asp
            4020                4025                4030        
Ile Val His Asp Leu Glu Ser Pro Gly Ile Asp Pro Ser Ile Ile Lys
        4035                4040                4045            
Gln Gln Val Glu Ala Ala Glu Thr Ile Lys Glu Glu Thr Asp Gly Leu
    4050                4055                4060                
His Glu Glu Leu Glu Phe Ile Arg Ile Leu Gly Ala Asp Leu Ile Phe
4065                4070                4075                4080
Ala Cys Gly Glu Thr Glu Lys Pro Glu Val Arg Lys Ser Ile Asp Glu
                4085                4090                4095    
Met Asn Asn Ala Trp Glu Asn Leu Asn Lys Thr Trp Lys Glu Arg Leu
            4100                4105                4110        
Glu Lys Leu Glu Asp Ala Met Gln Ala Ala Val Gln Tyr Gln Asp Thr
        4115                4120                4125            
Leu Gln Ala Met Phe Asp Trp Leu Asp Asn Thr Val Ile Lys Leu Cys
    4130                4135                4140                
Thr Met Pro Pro Val Gly Thr Asp Leu Asn Thr Val Lys Asp Gln Leu
4145                4150                4155                4160
Asn Glu Met Lys Glu Phe Lys Val Glu Val Tyr Gln Gln Gln Ile Glu
                4165                4170                4175    
Met Glu Lys Leu Asn His Gln Gly Glu Leu Met Leu Lys Lys Ala Thr
            4180                4185                4190        
Asp Glu Thr Asp Arg Asp Ile Ile Arg Glu Pro Leu Thr Glu Leu Lys
        4195                4200                4205            
His Leu Trp Glu Asn Leu Gly Glu Lys Ile Ala His Arg Gln His Lys
    4210                4215                4220                
Leu Glu Gly Ala Leu Leu Ala Leu Gly Gln Phe Gln His Ala Leu Glu
4225                4230                4235                4240
Glu Leu Met Ser Trp Leu Thr His Thr Glu Glu Leu Leu Asp Ala Gln
                4245                4250                4255    
Arg Pro Ile Ser Gly Asp Pro Lys Val Ile Glu Val Glu Leu Ala Lys
            4260                4265                4270        
His His Val Leu Lys Asn Asp Val Leu Ala His Gln Ala Thr Val Glu
        4275                4280                4285            
Thr Val Asn Lys Ala Gly Asn Glu Leu Leu Glu Ser Ser Ala Gly Asp
    4290                4295                4300                
Asp Ala Ser Ser Leu Arg Ser Arg Leu Glu Ala Met Asn Gln Cys Trp
4305                4310                4315                4320
Glu Ser Val Leu Gln Lys Thr Glu Glu Arg Glu Gln Gln Leu Gln Ser
                4325                4330                4335    
Thr Leu Gln Gln Ala Gln Gly Phe His Ser Glu Ile Glu Asp Phe Leu
            4340                4345                4350        
Leu Glu Leu Thr Arg Met Glu Ser Gln Leu Ser Ala Ser Lys Pro Thr
        4355                4360                4365            
Gly Gly Leu Pro Glu Thr Ala Arg Glu Gln Leu Asp Thr His Met Glu
    4370                4375                4380                
Leu Tyr Ser Gln Leu Lys Ala Lys Glu Glu Thr Tyr Asn Gln Leu Leu
4385                4390                4395                4400
Asp Lys Gly Arg Leu Met Leu Leu Ser Arg Asp Asp Ser Gly Ser Gly
                4405                4410                4415    
Ser Lys Thr Glu Gln Ser Val Ala Leu Leu Glu Gln Lys Trp His Val
            4420                4425                4430        
Val Ser Ser Lys Met Glu Glu Arg Lys Ser Lys Leu Glu Glu Ala Leu
        4435                4440                4445            
Asn Leu Ala Thr Glu Phe Gln Asn Ser Leu Gln Glu Phe Ile Asn Trp
    4450                4455                4460                
Leu Thr Leu Ala Glu Gln Ser Leu Asn Ile Ala Ser Pro Pro Ser Leu
4465                4470                4475                4480
Ile Leu Asn Thr Val Leu Ser Gln Ile Glu Glu His Lys Val Phe Ala
                4485                4490                4495    
Asn Glu Val Asn Ala His Arg Asp Gln Ile Ile Glu Leu Asp Gln Thr
            4500                4505                4510        
Gly Asn Gln Leu Lys Phe Leu Ser Gln Lys Gln Asp Val Val Leu Ile
        4515                4520                4525            
Lys Asn Leu Leu Val Ser Val Gln Ser Arg Trp Glu Lys Val Val Gln
    4530                4535                4540                
Arg Ser Ile Glu Arg Gly Arg Ser Leu Asp Asp Ala Arg Lys Arg Ala
4545                4550                4555                4560
Lys Gln Phe His Glu Ala Trp Lys Lys Leu Ile Asp Trp Leu Glu Asp
                4565                4570                4575    
Ala Glu Ser His Leu Asp Ser Glu Leu Glu Ile Ser Asn Asp Pro Asp
            4580                4585                4590        
Lys Ile Lys Leu Gln Leu Ser Lys His Lys Glu Phe Gln Lys Thr Leu
        4595                4600                4605            
Gly Gly Lys Gln Pro Val Tyr Asp Thr Thr Ile Arg Thr Gly Arg Ala
    4610                4615                4620                
Leu Lys Glu Lys Thr Leu Leu Pro Glu Asp Ser Gln Lys Leu Asp Asn
4625                4630                4635                4640
Phe Leu Gly Glu Val Arg Asp Lys Trp Asp Thr Val Cys Gly Lys Ser
                4645                4650                4655    
Val Glu Arg Gln His Lys Leu Glu Glu Ala Leu Leu Phe Ser Gly Gln
            4660                4665                4670        
Phe Met Asp Ala Leu Gln Ala Leu Val Asp Trp Leu Tyr Lys Val Glu
        4675                4680                4685            
Pro Gln Leu Ala Glu Asp Gln Pro Val His Gly Asp Leu Asp Leu Val
    4690                4695                4700                
Met Asn Leu Met Asp Ala His Lys Val Phe Gln Lys Glu Leu Gly Lys
4705                4710                4715                4720
Arg Thr Gly Thr Val Gln Val Leu Lys Arg Ser Gly Arg Glu Leu Ile
                4725                4730                4735    
Glu Asn Ser Arg Asp Asp Thr Thr Trp Val Lys Gly Gln Leu Gln Glu
            4740                4745                4750        
Leu Ser Thr Arg Trp Asp Thr Val Cys Lys Leu Ser Val Ser Lys Gln
        4755                4760                4765            
Ser Arg Leu Glu Gln Ala Leu Lys Gln Ala Glu Val Phe Arg Asp Thr
    4770                4775                4780                
Val His Met Leu Leu Glu Trp Leu Ser Glu Ala Glu Gln Thr Leu Arg
4785                4790                4795                4800
Phe Arg Gly Ala Leu Pro Asp Asp Thr Glu Ala Leu Gln Ser Leu Ile
                4805                4810                4815    
Asp Thr His Lys Glu Phe Met Lys Lys Val Glu Glu Lys Arg Val Asp
            4820                4825                4830        
Val Asn Ser Ala Val Ala Met Gly Glu Val Ile Leu Ala Val Cys His
        4835                4840                4845            
Pro Asp Cys Ile Thr Thr Ile Lys His Trp Ile Thr Ile Ile Arg Ala
    4850                4855                4860                
Arg Phe Glu Glu Val Leu Thr Trp Ala Lys Gln His Gln Gln Arg Leu
4865                4870                4875                4880
Glu Thr Ala Leu Ser Glu Leu Val Ala Asn Ala Glu Leu Leu Glu Glu
                4885                4890                4895    
Leu Leu Ala Trp Ile Gln Trp Ala Glu Thr Thr Leu Ile Gln Arg Asp
            4900                4905                4910        
Gln Glu Pro Ile Pro Gln Asn Ile Asp Arg Val Lys Ala Leu Ile Ala
        4915                4920                4925            
Glu His Gln Thr Phe Met Glu Glu Met Thr Arg Lys Gln Pro Asp Val
    4930                4935                4940                
Asp Arg Val Thr Lys Thr Tyr Lys Arg Lys Asn Ile Glu Pro Thr His
4945                4950                4955                4960
Ala Pro Phe Ile Glu Lys Ser Arg Ser Gly Gly Arg Lys Ser Leu Ser
                4965                4970                4975    
Gln Pro Thr Pro Pro Pro Met Pro Ile Leu Ser Gln Ser Glu Ala Lys
            4980                4985                4990        
Asn Pro Arg Ile Asn Gln Leu Ser Ala Arg Trp Gln Gln Val Trp Leu
        4995                5000                5005            
Leu Ala Leu Glu Arg Gln Arg Lys Leu Asn Asp Ala Leu Asp Arg Leu
    5010                5015                5020                
Glu Glu Leu Lys Glu Phe Ala Asn Phe Asp Phe Asp Val Trp Arg Lys
5025                5030                5035                5040
Lys Tyr Met Arg Trp Met Asn His Lys Lys Ser Arg Val Met Asp Phe
                5045                5050                5055    
Phe Arg Arg Ile Asp Lys Asp Gln Asp Gly Lys Ile Thr Arg Gln Glu
            5060                5065                5070        
Phe Ile Asp Gly Ile Leu Ala Ser Lys Phe Pro Thr Thr Lys Leu Glu
        5075                5080                5085            
Met Thr Ala Val Ala Asp Ile Phe Asp Arg Asp Gly Asp Gly Tyr Ile
    5090                5095                5100                
Asp Tyr Tyr Glu Phe Val Ala Ala Leu His Pro Asn Lys Asp Ala Tyr
5105                5110                5115                5120
Arg Pro Thr Thr Asp Ala Asp Lys Ile Glu Asp Glu Val Thr Arg Gln
                5125                5130                5135    
Val Ala Gln Cys Lys Cys Ala Lys Arg Phe Gln Val Glu Gln Ile Gly
            5140                5145                5150        
Glu Asn Lys Tyr Arg Phe Gly Asp Ser Gln Gln Leu Arg Leu Val Arg
        5155                5160                5165            
Ile Leu Arg Ser Thr Val Met Val Arg Val Gly Gly Gly Trp Met Ala
    5170                5175                5180                
Leu Asp Glu Phe Leu Val Lys Asn Asp Pro Cys Arg Ala Arg Gly Arg
5185                5190                5195                5200
Thr Asn Ile Glu Leu Arg Glu Lys Phe Ile Leu Pro Glu Gly Ala Ser
                5205                5210                5215    
Gln Gly Met Thr Pro Phe Arg Ser Arg Gly Arg Arg Ser Lys Pro Ser
            5220                5225                5230        
Ser Arg Ala Ala Ser Pro Thr Arg Ser Ser Ser Ser Ala Ser Gln Ser
        5235                5240                5245            
Asn His Ser Cys Thr Ser Met Pro Ser Ser Pro Ala Thr Pro Ala Ser
    5250                5255                5260                
Gly Thr Lys Val Ile Pro Ser Ser Gly Ser Lys Leu Lys Arg Pro Thr
5265                5270                5275                5280
Pro Thr Phe His Ser Ser Arg Thr Ser Leu Ala Gly Asp Thr Ser Asn
                5285                5290                5295    
Ser Ser Ser Pro Ala Ser Thr Gly Ala Lys Thr Asn Arg Ala Asp Pro
            5300                5305                5310        
Lys Lys Ser Ala Ser Arg Pro Gly Ser Arg Ala Gly Ser Arg Ala Gly
        5315                5320                5325            
Ser Arg Ala Ser Ser Arg Arg Gly Ser Asp Ala Ser Asp Phe Asp Leu
    5330                5335                5340                
Leu Glu Thr Gln Ser Ala Cys Ser Asp Thr Ser Glu Ser Ser Ala Ala
5345                5350                5355                5360
Gly Gly Gln Gly Asn Ser Arg Arg Gly Leu Asn Lys Pro Ser Lys Ile
                5365                5370                5375    
Pro Thr Met Ser Lys Lys Thr Thr Thr Ala Ser Pro Arg Thr Pro Gly
            5380                5385                5390        
Pro Lys Arg
        5395


<210> 6057
<211> 5938
<212> PRT
<213> Homo sapiens

<400> 6057
Met Gln Lys Gly Leu Leu Asp Gln Asp Thr Gly Leu Val Leu Leu Glu
 1               5                  10                  15      
Ser Gln Val Ile Met Ser Gly Leu Ile Ala Pro Glu Thr Gly Glu Asn
            20                  25                  30          
Leu Ser Leu Glu Glu Gly Ile Ala Arg Asn Leu Ile Asn Pro Gln Met
        35                  40                  45              
Tyr Gln Gln Leu Arg Glu Leu Gln Asp Ala Leu Ala Leu Ile Ser Arg
    50                  55                  60                  
Leu Thr Glu Ser Arg Gly Pro Leu Ser Val Val Glu Ala Ile Glu Lys
65                  70                  75                  80  
Arg Ile Ile Ser Glu Thr Val Gly Leu Lys Ile Leu Glu Ala His Leu
                85                  90                  95      
Ala Thr Gly Gly Phe Ser Leu Ser Pro Ser Glu Asn Cys Ile Asn Leu
            100                 105                 110         
Glu Glu Ala Phe His Gln Gly Leu Ile Ser Ala Trp Leu His Ser Val
        115                 120                 125             
Leu Glu Ser Tyr Leu Arg Thr Ser Lys Asn Leu Ile Asp Pro Asn Thr
    130                 135                 140                 
Ala Glu Lys Ile Gly Leu Leu Asp Leu Met Gln Arg Cys Ile Val His
145                 150                 155                 160 
Gln Glu Ser Gly Phe Lys Leu Leu Pro Val Lys Gln Leu Ala Gly Gly
                165                 170                 175     
Met Val Ser Leu Lys Ser Gly Arg Lys Val Ser Ile Phe Arg Ala Val
            180                 185                 190         
Gln Glu Gly Leu Ile Asp Arg Gln Val Thr Val Arg Leu Leu Glu Ala
        195                 200                 205             
Gln Leu Phe Ala Gly Gly Ile Val Asp Pro Arg Thr Gly His Arg Leu
    210                 215                 220                 
Thr Val Glu Glu Ala Val Arg His Asn Leu Ile Asp Gln Asp Met Ala
225                 230                 235                 240 
Cys Ala Ile Leu Ile Arg Gln Leu Gln Thr Gly Gly Ile Ile Asp Thr
                245                 250                 255     
Val Thr Gly Gln Arg Leu Thr Ile Asp Glu Ala Val Ser Asn Asp Leu
            260                 265                 270         
Val Ala Ala Lys Ile Ala Leu Val Ile Leu Glu Ser Leu Trp Ser Phe
        275                 280                 285             
Met Gly Leu Leu Trp Pro Glu Ser Gly Glu Ile Leu Pro Ile Thr Asp
    290                 295                 300                 
Ala Leu Glu Gln Gly Ile Val Ser Thr Glu Leu Ala His Lys Ile Leu
305                 310                 315                 320 
Ser Asn Arg Gln His Ile Lys Ala Leu Phe Leu Pro Ala Thr Thr Glu
                325                 330                 335     
Ile Leu Ser Trp Lys Lys Ala Ile Glu Ser Gly Ile Leu Asp Arg Asp
            340                 345                 350         
Leu Ala Asn Asn Leu Lys Ser Ile Cys Ile Pro Asp Val Met Pro His
        355                 360                 365             
Met Gln Leu Ala Asp Ser Ala Glu Gln Asn Ile Asn Pro Gly Ala Ala
    370                 375                 380                 
Val Leu Pro Cys Ser Lys Ser His Pro Lys Ala Thr Ala Ser Gln Ser
385                 390                 395                 400 
Glu Asn Leu Leu Phe Gln Leu Met Thr His Ser Tyr Ile Asn Val Gln
                405                 410                 415     
Asn Gly Gln Arg Leu Leu Leu Leu Asp Lys Glu Leu Met Glu Thr Leu
            420                 425                 430         
Thr Ser Arg Asp Glu Tyr Gln Thr Ser Pro Pro Lys Val Val Glu Ile
        435                 440                 445             
Gly His Gln Arg Gln Lys Thr Pro Glu Gly Leu Gln Glu Ser Ala Asn
    450                 455                 460                 
Val Lys Ile Ser Gly Thr Phe Ser Ser Gly Trp Thr Val Arg Leu Pro
465                 470                 475                 480 
Glu Phe Gln Phe Ser Ser Gln Asn Lys Glu Tyr Pro Asp Arg Glu Asp
                485                 490                 495     
Cys Thr Thr Glu Lys Gly Lys Lys Thr Thr Val Glu Thr Glu Asp Ser
            500                 505                 510         
Ser Val Glu Asn Pro Glu Gln Asp Leu Phe Val Glu Gln Lys Glu Arg
        515                 520                 525             
Asn Pro Asn Ile Asp Ala Leu Lys Val Ile Asn Lys Val Lys Leu Glu
    530                 535                 540                 
Val Gln Arg Gln Leu Ile Gly Thr Gln Arg Glu Asp Gln Thr Ala Val
545                 550                 555                 560 
Ser Val Arg Glu Asn Ala Ser Arg Gly His Leu Leu Thr Ile Pro Pro
                565                 570                 575     
Ala Glu Ala Glu Gly Val Pro Leu Val Val Asp Lys Asp Val Phe Ser
            580                 585                 590         
Val Glu Thr Pro Lys Lys Glu His Gln Pro Leu Arg Asn Thr Ser Phe
        595                 600                 605             
Thr Cys Gln Asn Glu Gln Ala His Thr Leu Glu Thr Glu Tyr Ile His
    610                 615                 620                 
Asp Glu Thr Gly Gly Ser His Ile Lys Pro Gln Ser Lys Lys Leu Gln
625                 630                 635                 640 
Val Gln Val Lys Lys Thr Leu Gly Ile Lys Leu Glu Leu Lys Ser Glu
                645                 650                 655     
Thr Asp Gly Asn Val His Pro Leu Asp Lys Lys Glu Met Leu Lys Lys
            660                 665                 670         
Thr Phe Leu Ala Lys Asp Asp His Lys Glu Ser Gln Glu Ala Gln Asn
        675                 680                 685             
Ile Ala Gly Gly Ser Met Met Met Ser Glu Lys Thr Asp Glu Glu Asp
    690                 695                 700                 
Ser Gly Arg Glu Ile Phe Leu Ser Cys Ser His Pro Leu Glu Leu Leu
705                 710                 715                 720 
Glu Glu Ala Thr Leu Asn Val Leu Ser Ala Gln Leu Leu Asp Gly Gly
                725                 730                 735     
Ile Phe His Glu Gln Thr Gly Gln Lys Leu Leu Leu Asn Glu Ala Ile
            740                 745                 750         
Ser Arg Gly Ile Val Pro Ser His Thr Ala Val Lys Leu Met Glu Lys
        755                 760                 765             
Leu Asn Met Phe Gln Gly Phe Phe Asp Ser Gln Thr Cys Glu Ser Leu
    770                 775                 780                 
Thr Thr Glu Glu Val Ile Asn Glu Gly Leu Met Asp Glu Lys Leu Leu
785                 790                 795                 800 
His Asn Val Leu Met Ala Asp Lys Ala Ile Ser Gly Val Leu Asp Pro
                805                 810                 815     
Arg Thr Gln Thr Leu Cys Ser Val Lys Asp Ala Val Thr Val Gly Leu
            820                 825                 830         
Leu Asp Lys Glu Thr Ala Thr Arg Ile Leu Glu Arg Gln Val Val Thr
        835                 840                 845             
Gly Gly Ile Ile Asp Leu Lys Arg Gly Lys Lys Val Ser Val Thr Leu
    850                 855                 860                 
Ala Ser Thr Leu Gly Leu Val Asp Val Ala Asp Gln Pro Glu Leu Ile
865                 870                 875                 880 
Asn Leu Glu Lys Ala Ser Lys Gly Arg Asp Ala Glu Lys Thr Val Arg
                885                 890                 895     
Glu Arg Leu Ile Ser Leu Gln Met Glu Thr Thr Gly Leu Ile Asp Pro
            900                 905                 910         
Asp Ser Lys Ala Pro Leu Thr Val Val Gln Ser Ile Asp Arg Gly Leu
        915                 920                 925             
Leu Glu Arg Glu Glu Ala Val Arg Leu Leu Thr Lys Gln Val Val Asp
    930                 935                 940                 
Gly Gly Ile Ile His His Ile Ser Gly Met Arg Leu Ser Val Asp Asn
945                 950                 955                 960 
Ala Phe Arg His Gly Leu Ile Gly Glu Asp Leu Ala Glu Lys Leu Lys
                965                 970                 975     
Arg Val Glu Asn Leu Asn Ile His Gln Ile Phe Asn Pro Glu Thr Lys
            980                 985                 990         
Glu Asn Ile Ser Leu Pro Lys Ala Ile Lys Leu Asp Leu Ile Thr Ser
        995                 1000                1005            
Asp Leu Lys Arg Glu Ile Gln Glu Val Gln Ala Phe Thr Gly Asn Phe
    1010                1015                1020                
Val Asp Leu Ile Ser Gly Gln Arg Leu Thr Leu Ala Glu Ala Lys Lys
1025                1030                1035                1040
Glu Gly Leu Leu Thr Asn Glu Ala Val Leu Ser Pro Gly Met Met His
                1045                1050                1055    
Gly Ile Val Asp Pro Glu Asn Cys Arg Ile Val Pro Tyr Ser Glu Leu
            1060                1065                1070        
Val Lys Lys Cys Lys Ile Asp Ile Glu Ser Gly Gln Arg Tyr Leu Glu
        1075                1080                1085            
Val Ile Pro Phe Ser Asp Ile Lys Asp Gly Val Ser Asp Lys Val Leu
    1090                1095                1100                
Thr Leu Ser Gln Ala Ile Gln Leu Gly Lys Val Asp Phe Ala Ser Thr
1105                1110                1115                1120
Leu Lys Val Leu Glu Ala Gln Ala Asn Thr Gly Gly Ile Ile Asp Thr
                1125                1130                1135    
Ala Thr Gly Lys Arg Leu Thr Leu Ala Ser Ala Leu Glu Glu Lys Leu
            1140                1145                1150        
Val Asp Glu Asn Met Val Arg Ile Ile Ala Ser His Gln Val Leu Asn
        1155                1160                1165            
Gly Gly Ile Val Asp Ile Phe Ser Asp Gln Arg Val Thr Leu Val Glu
    1170                1175                1180                
Ala Ile Glu Lys Arg Leu Ile Ser Pro Glu Leu Ala Asn Met Ile Gln
1185                1190                1195                1200
Ile Asp Ser Ser Glu Phe Ser Asp His Arg Ala Gln Ile Glu Lys Gln
                1205                1210                1215    
Glu Gly Ile Glu Val Cys Ala Leu Gln Asn Glu Phe Leu Gly Lys Asp
            1220                1225                1230        
Met Leu Ile Ala Cys Asn Gln Thr Ala Glu Met Ser Cys Asn Lys Val
        1235                1240                1245            
Glu Glu Ser Glu Arg Leu Phe Gln Val Glu Asn Gln Ser Ala Gln Glu
    1250                1255                1260                
Lys Val Lys Val Arg Val Ser Asp Gly Glu Gln Ala Lys Lys Ser Arg
1265                1270                1275                1280
Glu Ile Ser Leu Lys Glu Phe Gly Cys Lys Asp Gln Arg Lys Pro Arg
                1285                1290                1295    
Met Ser Ser Asp Ala Lys Glu Phe Ile Ser Ile Ile Asn Pro His Asn
            1300                1305                1310        
Leu Lys Gly Lys Ser Leu Gly Gln Val Ser Leu Thr His Pro Tyr Ser
        1315                1320                1325            
Glu Cys Asp Phe Lys Leu Lys Glu Val Ala Arg Asn Asn Met Gly Asn
    1330                1335                1340                
Asp Thr Asn Glu Glu Gln Glu Lys Ala Val Thr Lys Ile Glu Ile Ile
1345                1350                1355                1360
Ser His Met Lys Gln Ser Thr Ser Cys Leu Asp Ser Glu Glu Ile Arg
                1365                1370                1375    
Glu Asn Gln Gly Glu Val Ile Leu Glu Val Gln Glu Thr Tyr Cys Glu
            1380                1385                1390        
Thr Ser Gly Lys Leu Pro Ser Glu Gln Val Leu Gln Gln Pro Met Asn
        1395                1400                1405            
Ala Arg Val Lys Ser Lys Arg Glu Lys Arg Glu Val Ile Val Glu Glu
    1410                1415                1420                
Ser Ile Arg Thr Cys Lys Pro Ala Phe Leu Ser Glu Glu Lys Leu Tyr
1425                1430                1435                1440
Gln Glu Thr Ala Ile Arg Asp Glu His Asp Ser His Ile Lys Ser Gln
                1445                1450                1455    
Pro Arg Glu Met Thr Ser Ser Glu Lys Gly Lys Glu Ala Asp Thr Glu
            1460                1465                1470        
Met Gly Phe Ser Ile Thr Phe Lys Ile Glu Glu Ser Ser Ser Gln Val
        1475                1480                1485            
Val Pro Gln Gly Ile Ser Val Lys His Leu Asp Ala Leu Thr Leu Phe
    1490                1495                1500                
Ser Ser Lys Gln Ala Asn Glu Gly Lys Val Asn Asn Leu Ser Leu Cys
1505                1510                1515                1520
Leu Thr Leu Lys Pro Glu Glu Asn Leu Ser Arg Glu Ile Ala Cys Gly
                1525                1530                1535    
Ala Gln Ser Glu Pro Phe Pro Cys Met Thr Pro Arg Pro Glu Gly Leu
            1540                1545                1550        
His Tyr Gln Glu Ser Asp Gly Lys Ala Gln Val Thr Gly Pro Ser Gln
        1555                1560                1565            
Ile Ser Lys Thr Asp Lys Ser Phe Gln Gly Thr Thr Arg Gln Glu Thr
    1570                1575                1580                
Asn Tyr Gln Asp Ser Trp Val Thr Ser Lys Thr Lys Glu Thr Lys His
1585                1590                1595                1600
Gln Ile Ser Ser Ser Asn Glu Cys Lys Glu Lys Ser Tyr Gln Glu Val
                1605                1610                1615    
Ser Phe Asp Pro Ala Arg Gly Leu Lys Leu Glu Glu Ile Thr Val Ser
            1620                1625                1630        
Arg Pro Asp Ser Lys Glu Val Arg Tyr Leu Glu Phe Ser Asp Arg Lys
        1635                1640                1645            
Asp Leu His His Gln Gly Ser Lys Ser Asp Asp Lys Leu Cys Gly Thr
    1650                1655                1660                
Leu Lys Ser Glu Ile Ala Thr Gln Glu Leu Thr Gly Glu Lys Phe Leu
1665                1670                1675                1680
Glu Met Ala Asn Pro Asn Val Ala Gly Leu Glu Ala Gly Ser Ile Glu
                1685                1690                1695    
Asp Ile Val Thr Gln Arg Gly Ser Arg Val Leu Gly Ser Phe Leu Pro
            1700                1705                1710        
Glu Lys Leu Phe Lys Gly Val Ser Gln Lys Glu Asn Thr Gly Gln Gln
        1715                1720                1725            
Asn Ala Ile Ile Ser Pro Thr Val Leu Glu Thr Ser Glu Glu Lys Thr
    1730                1735                1740                
Val Ser Leu Thr Val Cys Ser Ala Val Lys Thr Glu Lys Thr Pro Gln
1745                1750                1755                1760
Glu Lys Leu Arg Glu Ser Pro Gly Ser Glu Gln Thr Pro Phe Met Thr
                1765                1770                1775    
Ala Pro Glu Gly Lys Gly Asn Gly Gly Val Asn Pro Glu Pro Phe Arg
            1780                1785                1790        
Ala Thr Gln Asn Val Phe Thr Arg Gln Leu Cys Leu Glu His Asp Glu
        1795                1800                1805            
Lys Leu Val Ser Tyr Leu Ser Leu Leu Arg Asn Ile Glu Met Arg Thr
    1810                1815                1820                
Lys Gln Ile Gln Pro Leu Glu Leu Asn Leu Ala Glu Leu Gln Asp Leu
1825                1830                1835                1840
Leu Cys Gln Ala Lys Val Leu Glu Arg Glu Leu Lys Asp Leu Thr Thr
                1845                1850                1855    
Leu Val Ser Gln Glu Leu Glu Cys Val Asn Gln Ile Ile Ile Ser Gln
            1860                1865                1870        
Pro Gln Glu Val Pro Ala Gln Leu Leu Lys Ala Leu Glu Lys Asp Ala
        1875                1880                1885            
Lys Asn Leu Gln Lys Ser Leu Ser Ser Val Ser Asp Thr Trp Asn Ser
    1890                1895                1900                
Arg Leu Leu His Phe Gln Asn Ala Val Glu Ile Glu Lys Thr Lys Val
1905                1910                1915                1920
Leu Asn Gln His Thr Gln Leu Glu Gly Arg Leu Gln Asp Leu Arg Ala
                1925                1930                1935    
Trp Val Gly Asn Lys Asn Leu Ile Leu Asn Ser Lys Gly Ser Asn Ser
            1940                1945                1950        
Glu Ile Asp Val Asp Ser Leu Asn Leu Cys Leu Gln Gln Tyr Glu Asp
        1955                1960                1965            
Leu Lys Gln Pro Met Ala Glu Arg Lys Ala Gln Leu Asp Ala Leu Ala
    1970                1975                1980                
Phe Asp Ile Gln Phe Phe Ile Ser Glu His Ala Gln Asp Leu Ser Pro
1985                1990                1995                2000
Gln Gln Asn Arg Gln Met Leu Arg Leu Leu Asn Glu Leu Gln Arg Ser
                2005                2010                2015    
Phe Gln Asp Ile Leu Glu Gln Thr Ala Ala Gln Val Asp Ala Leu Gln
            2020                2025                2030        
Gly His Leu Gln Gln Met Glu Gln Glu Ala Leu Val Lys Thr Leu Gln
        2035                2040                2045            
Lys Gln Gln Asn Thr Cys His Gln Gln Leu Glu Asp Leu Cys Ser Trp
    2050                2055                2060                
Val Gly Gln Ala Glu Arg Ala Leu Ala Gly His Gln Gly Arg Thr Thr
2065                2070                2075                2080
Gln Gln Asp Leu Ser Ala Leu Gln Lys Asn Gln Ser Asp Leu Lys Asp
                2085                2090                2095    
Leu Gln Asp Asp Ile Gln Asn Arg Ala Thr Ser Phe Ala Thr Val Val
            2100                2105                2110        
Lys Asp Ile Glu Gly Phe Met Glu Glu Asn Gln Thr Lys Leu Ser Pro
        2115                2120                2125            
Arg Glu Leu Thr Ala Leu Arg Glu Lys Leu His Gln Ala Lys Glu Gln
    2130                2135                2140                
Tyr Glu Ala Leu Gln Glu Glu Thr Arg Val Ala Gln Lys Glu Leu Glu
2145                2150                2155                2160
Glu Ala Val Thr Ser Ala Leu Gln Gln Glu Thr Glu Lys Ser Lys Ala
                2165                2170                2175    
Ala Lys Glu Leu Ala Glu Asn Lys Lys Lys Ile Asp Ala Leu Leu Asp
            2180                2185                2190        
Trp Val Thr Ser Val Gly Ser Ser Gly Gly Gln Leu Leu Thr Asn Leu
        2195                2200                2205            
Pro Gly Met Glu Gln Leu Ser Gly Ala Ser Leu Glu Lys Gly Ala Leu
    2210                2215                2220                
Asp Thr Thr Asp Gly Tyr Met Gly Val Asn Gln Ala Pro Glu Lys Leu
2225                2230                2235                2240
Asp Lys Gln Cys Glu Met Met Lys Ala Arg His Gln Glu Leu Leu Ser
                2245                2250                2255    
Gln Gln Gln Asn Phe Ile Leu Ala Thr Gln Ser Ala Gln Ala Phe Leu
            2260                2265                2270        
Asp Gln His Gly His Asn Leu Thr Pro Glu Glu Gln Gln Met Leu Gln
        2275                2280                2285            
Gln Lys Leu Gly Glu Leu Lys Glu Gln Tyr Ser Thr Ser Leu Ala Gln
    2290                2295                2300                
Ser Glu Ala Glu Leu Lys Gln Val Gln Thr Leu Gln Asp Glu Leu Gln
2305                2310                2315                2320
Lys Phe Leu Gln Asp His Lys Glu Phe Glu Ser Trp Leu Glu Arg Ser
                2325                2330                2335    
Glu Lys Glu Leu Glu Asn Met His Lys Gly Gly Ser Ser Pro Glu Thr
            2340                2345                2350        
Leu Pro Ser Leu Leu Lys Arg Gln Gly Ser Phe Ser Glu Asp Val Ile
        2355                2360                2365            
Ser His Lys Gly Asp Leu Arg Phe Val Thr Ile Ser Gly Gln Lys Val
    2370                2375                2380                
Leu Asp Met Glu Asn Ser Phe Lys Glu Gly Lys Glu Pro Ser Glu Ile
2385                2390                2395                2400
Gly Asn Leu Val Lys Asp Lys Leu Lys Asp Ala Thr Glu Arg Tyr Thr
                2405                2410                2415    
Ala Leu His Ser Lys Cys Thr Arg Leu Gly Ser His Leu Asn Met Leu
            2420                2425                2430        
Leu Gly Gln Tyr His Gln Phe Gln Asn Ser Ala Asp Ser Leu Gln Ala
        2435                2440                2445            
Trp Met Gln Ala Cys Glu Ala Asn Val Glu Lys Leu Leu Ser Asp Thr
    2450                2455                2460                
Val Ala Ser Asp Pro Gly Val Leu Gln Glu Gln Leu Ala Thr Thr Lys
2465                2470                2475                2480
Gln Leu Gln Glu Glu Leu Ala Glu His Gln Val Pro Val Glu Lys Leu
                2485                2490                2495    
Gln Lys Val Ala Arg Asp Ile Met Glu Ile Glu Gly Glu Pro Ala Pro
            2500                2505                2510        
Asp His Arg His Val Gln Glu Thr Thr Asp Ser Ile Leu Ser His Phe
        2515                2520                2525            
Gln Ser Leu Ser Tyr Ser Leu Ala Glu Arg Ser Ser Leu Leu Gln Lys
    2530                2535                2540                
Ala Ile Ala Gln Ser Gln Ser Val Gln Glu Ser Leu Glu Ser Leu Leu
2545                2550                2555                2560
Gln Ser Ile Gly Glu Val Glu Gln Asn Leu Glu Gly Lys Gln Val Ser
                2565                2570                2575    
Ser Leu Ser Ser Gly Val Ile Gln Glu Ala Leu Ala Thr Asn Met Lys
            2580                2585                2590        
Leu Lys Gln Asp Ile Ala Arg Gln Lys Ser Ser Leu Glu Ala Thr Arg
        2595                2600                2605            
Glu Met Val Thr Arg Phe Met Glu Thr Ala Asp Ser Thr Thr Ala Ala
    2610                2615                2620                
Val Leu Gln Gly Lys Leu Ala Glu Val Ser Gln Arg Phe Glu Gln Leu
2625                2630                2635                2640
Cys Leu Gln Gln Gln Glu Lys Glu Ser Ser Leu Lys Lys Leu Leu Pro
                2645                2650                2655    
Gln Ala Glu Met Phe Glu His Leu Ser Gly Lys Leu Gln Gln Phe Met
            2660                2665                2670        
Glu Asn Lys Ser Arg Met Leu Ala Ser Gly Asn Gln Pro Asp Gln Asp
        2675                2680                2685            
Ile Thr His Phe Phe Gln Gln Ile Gln Glu Leu Asn Leu Glu Met Glu
    2690                2695                2700                
Asp Gln Gln Glu Asn Leu Asp Thr Leu Glu His Leu Val Thr Glu Leu
2705                2710                2715                2720
Ser Ser Cys Gly Phe Ala Leu Asp Leu Cys Gln His Gln Asp Arg Val
                2725                2730                2735    
Gln Asn Leu Arg Lys Asp Phe Thr Glu Leu Gln Lys Thr Val Lys Glu
            2740                2745                2750        
Arg Glu Lys Asp Ala Ser Ser Cys Gln Glu Gln Leu Asp Glu Phe Arg
        2755                2760                2765            
Lys Leu Val Arg Thr Phe Gln Lys Trp Leu Lys Glu Thr Glu Gly Ser
    2770                2775                2780                
Ile Pro Pro Thr Glu Thr Ser Met Ser Ala Lys Glu Leu Glu Lys Gln
2785                2790                2795                2800
Ile Glu His Leu Lys Ser Leu Leu Asp Asp Trp Ala Ser Lys Gly Thr
                2805                2810                2815    
Leu Val Glu Glu Ile Asn Cys Lys Gly Thr Ser Leu Glu Asn Leu Ile
            2820                2825                2830        
Met Glu Ile Thr Ala Pro Asp Ser Gln Gly Lys Thr Gly Ser Ile Leu
        2835                2840                2845            
Pro Ser Val Gly Ser Ser Val Gly Ser Val Asn Gly Tyr His Thr Cys
    2850                2855                2860                
Lys Asp Leu Thr Glu Ile Gln Cys Asp Met Ser Asp Val Asn Leu Lys
2865                2870                2875                2880
Tyr Glu Lys Leu Gly Gly Val Leu His Glu Arg Gln Glu Ser Leu Gln
                2885                2890                2895    
Ala Ile Leu Asn Arg Met Glu Glu Val His Lys Glu Ala Asn Ser Val
            2900                2905                2910        
Leu Gln Trp Leu Glu Ser Lys Glu Glu Val Leu Lys Ser Met Asp Ala
        2915                2920                2925            
Met Ser Ser Pro Thr Lys Thr Glu Thr Val Lys Ala Gln Ala Glu Ser
    2930                2935                2940                
Asn Lys Ala Phe Leu Ala Glu Leu Glu Gln Asn Ser Pro Lys Ile Gln
2945                2950                2955                2960
Lys Val Lys Glu Ala Leu Ala Gly Leu Leu Val Thr Tyr Pro Asn Ser
                2965                2970                2975    
Gln Glu Ala Glu Asn Trp Lys Lys Ile Gln Glu Glu Leu Asn Ser Arg
            2980                2985                2990        
Trp Glu Arg Ala Thr Glu Val Thr Val Ala Arg Gln Arg Gln Leu Glu
        2995                3000                3005            
Glu Ser Ala Ser His Leu Ala Cys Phe Gln Ala Ala Glu Ser Gln Leu
    3010                3015                3020                
Arg Pro Trp Leu Met Glu Lys Glu Leu Met Met Gly Val Leu Gly Pro
3025                3030                3035                3040
Leu Ser Ile Asp Pro Asn Met Leu Asn Ala Gln Lys Gln Gln Val Gln
                3045                3050                3055    
Phe Met Leu Lys Glu Phe Glu Ala Arg Arg Gln Gln His Glu Gln Leu
            3060                3065                3070        
Asn Glu Ala Ala Gln Gly Ile Leu Thr Gly Pro Gly Asp Val Ser Leu
        3075                3080                3085            
Ser Thr Ser Gln Val Gln Lys Glu Leu Gln Ser Ile Asn Gln Lys Trp
    3090                3095                3100                
Val Glu Leu Thr Asp Lys Leu Asn Ser Arg Ser Ser Gln Ile Asp Gln
3105                3110                3115                3120
Ala Ile Val Lys Ser Thr Gln Tyr Gln Glu Leu Leu Gln Asp Leu Ser
                3125                3130                3135    
Glu Lys Val Arg Ala Val Gly Gln Arg Leu Ser Val Gln Ser Ala Ile
            3140                3145                3150        
Ser Thr Gln Pro Glu Ala Val Lys Gln Gln Leu Glu Glu Thr Ser Glu
        3155                3160                3165            
Ile Arg Ser Asp Leu Glu Gln Leu Asp His Glu Val Lys Glu Ala Gln
    3170                3175                3180                
Thr Leu Cys Asp Glu Leu Ser Val Leu Ile Gly Glu Gln Tyr Leu Lys
3185                3190                3195                3200
Asp Glu Leu Lys Lys Arg Leu Glu Thr Val Ala Leu Pro Leu Gln Gly
                3205                3210                3215    
Leu Glu Asp Leu Ala Ala Asp Arg Ile Asn Arg Leu Gln Ala Ala Leu
            3220                3225                3230        
Ala Ser Thr Gln Gln Phe Gln Gln Met Phe Asp Glu Leu Arg Thr Trp
        3235                3240                3245            
Leu Asp Asp Lys Gln Ser Gln Gln Ala Lys Asn Cys Pro Ile Ser Ala
    3250                3255                3260                
Lys Leu Glu Arg Leu Gln Ser Gln Leu Gln Glu Asn Glu Glu Phe Gln
3265                3270                3275                3280
Lys Ser Leu Asn Gln His Ser Gly Ser Tyr Glu Val Ile Val Ala Glu
                3285                3290                3295    
Gly Glu Ser Leu Leu Leu Ser Val Pro Pro Gly Glu Glu Lys Arg Thr
            3300                3305                3310        
Leu Gln Asn Gln Leu Val Glu Leu Lys Asn His Trp Glu Glu Leu Ser
        3315                3320                3325            
Lys Lys Thr Ala Asp Arg Gln Ser Arg Leu Lys Asp Cys Met Gln Lys
    3330                3335                3340                
Ala Gln Lys Tyr Gln Trp His Val Glu Asp Leu Val Pro Trp Ile Glu
3345                3350                3355                3360
Asp Cys Lys Ala Lys Met Ser Glu Leu Arg Val Thr Leu Asp Pro Val
                3365                3370                3375    
Gln Leu Glu Ser Ser Leu Leu Arg Ser Lys Ala Met Leu Asn Glu Val
            3380                3385                3390        
Glu Lys Arg Arg Ser Leu Leu Glu Ile Leu Asn Ser Ala Ala Asp Ile
        3395                3400                3405            
Leu Ile Asn Ser Ser Glu Ala Asp Glu Asp Gly Ile Arg Asp Glu Lys
    3410                3415                3420                
Ala Gly Ile Asn Gln Asn Met Asp Ala Val Thr Glu Glu Leu Gln Ala
3425                3430                3435                3440
Lys Thr Gly Ser Leu Glu Glu Met Thr Gln Arg Leu Arg Glu Phe Gln
                3445                3450                3455    
Glu Ser Phe Lys Asn Ile Glu Lys Lys Val Glu Gly Ala Lys His Gln
            3460                3465                3470        
Leu Glu Ile Phe Asp Ala Leu Gly Ser Gln Ala Cys Ser Asn Lys Asn
        3475                3480                3485            
Leu Glu Lys Leu Arg Ala Gln Gln Glu Val Leu Gln Ala Leu Glu Pro
    3490                3495                3500                
Gln Val Asp Tyr Leu Arg Asn Phe Thr Gln Gly Leu Val Glu Asp Ala
3505                3510                3515                3520
Pro Asp Gly Ser Asp Ala Ser Gln Leu Leu His Gln Ala Glu Val Ala
                3525                3530                3535    
Gln Gln Glu Phe Leu Glu Val Lys Gln Arg Val Asn Ser Gly Cys Val
            3540                3545                3550        
Met Met Glu Asn Lys Leu Glu Gly Ile Gly Gln Phe His Cys Arg Val
        3555                3560                3565            
Arg Glu Met Phe Ser Gln Leu Ala Asp Leu Asp Asp Glu Leu Asp Gly
    3570                3575                3580                
Met Gly Ala Ile Gly Arg Asp Thr Asp Ser Leu Gln Ser Gln Ile Glu
3585                3590                3595                3600
Asp Val Arg Leu Phe Leu Asn Lys Ile His Val Leu Lys Leu Asp Ile
                3605                3610                3615    
Glu Ala Ser Glu Ala Glu Cys Arg His Met Leu Glu Glu Glu Gly Thr
            3620                3625                3630        
Leu Asp Leu Leu Gly Leu Lys Arg Glu Leu Glu Ala Leu Asn Lys Gln
        3635                3640                3645            
Cys Gly Lys Leu Thr Glu Arg Gly Lys Ala Arg Gln Glu Gln Leu Glu
    3650                3655                3660                
Leu Thr Leu Gly Arg Val Glu Asp Phe Tyr Arg Lys Leu Lys Gly Leu
3665                3670                3675                3680
Asn Asp Ala Thr Thr Ala Ala Glu Glu Ala Glu Ala Leu Gln Trp Val
                3685                3690                3695    
Val Gly Thr Glu Val Glu Ile Ile Asn Gln Gln Leu Ala Asp Phe Lys
            3700                3705                3710        
Met Phe Gln Lys Glu Gln Val Asp Pro Leu Gln Met Lys Leu Gln Gln
        3715                3720                3725            
Val Asn Gly Leu Gly Gln Gly Leu Ile Gln Ser Ala Gly Lys Asp Cys
    3730                3735                3740                
Asp Val Gln Gly Leu Glu His Asp Met Glu Glu Ile Asn Ala Arg Trp
3745                3750                3755                3760
Asn Thr Leu Asn Lys Lys Val Ala Gln Arg Ile Ala Gln Leu Gln Glu
                3765                3770                3775    
Ala Leu Leu His Cys Gly Lys Phe Gln Asp Ala Leu Glu Pro Leu Leu
            3780                3785                3790        
Ser Trp Leu Ala Asp Thr Glu Glu Leu Ile Ala Asn Gln Lys Pro Pro
        3795                3800                3805            
Ser Ala Glu Tyr Lys Val Val Lys Ala Gln Ile Gln Glu Gln Lys Leu
    3810                3815                3820                
Leu Gln Arg Leu Leu Asp Asp Arg Lys Ala Thr Val Asp Met Leu Gln
3825                3830                3835                3840
Ala Glu Gly Gly Arg Ile Ala Gln Ser Ala Glu Leu Ala Asp Arg Glu
                3845                3850                3855    
Lys Ile Thr Gly Gln Leu Glu Ser Leu Glu Ser Arg Trp Thr Glu Leu
            3860                3865                3870        
Leu Ser Lys Ala Ala Ala Arg Gln Lys Gln Leu Glu Asp Ile Leu Val
        3875                3880                3885            
Leu Ala Lys Gln Phe His Glu Thr Ala Glu Pro Ile Ser Asp Phe Leu
    3890                3895                3900                
Ser Val Thr Glu Lys Lys Leu Ala Asn Ser Glu Pro Val Gly Thr Gln
3905                3910                3915                3920
Thr Ala Lys Ile Gln Gln Gln Ile Ile Arg His Lys Ala Leu Glu Glu
                3925                3930                3935    
Asp Ile Glu Asn His Ala Thr Asp Val His Gln Ala Val Lys Ile Gly
            3940                3945                3950        
Gln Ser Leu Ser Ser Leu Thr Ser Pro Ala Glu Gln Gly Val Leu Ser
        3955                3960                3965            
Glu Lys Ile Asp Ser Leu Gln Ala Arg Tyr Ser Glu Ile Gln Asp Arg
    3970                3975                3980                
Cys Cys Arg Lys Ala Ala Leu Leu Asp Gln Ala Leu Ser Asn Ala Arg
3985                3990                3995                4000
Leu Phe Gly Glu Asp Glu Val Glu Val Leu Asn Trp Leu Ala Glu Val
                4005                4010                4015    
Glu Asp Lys Leu Ser Ser Val Phe Val Lys Asp Phe Lys Gln Asp Val
            4020                4025                4030        
Leu His Arg Gln His Ala Asp His Leu Ala Leu Asn Glu Glu Ile Val
        4035                4040                4045            
Asn Arg Lys Lys Asn Val Asp Gln Ala Ile Lys Asn Gly Gln Ala Leu
    4050                4055                4060                
Leu Lys Gln Thr Thr Gly Glu Glu Val Leu Leu Ile Gln Glu Lys Leu
4065                4070                4075                4080
Asp Gly Ile Lys Thr Arg Tyr Ala Asp Ile Thr Val Thr Ser Ser Lys
                4085                4090                4095    
Ala Leu Arg Thr Leu Glu Gln Ala Arg Gln Leu Ala Thr Lys Phe Gln
            4100                4105                4110        
Ser Thr Tyr Glu Glu Leu Thr Gly Trp Leu Arg Glu Val Glu Glu Glu
        4115                4120                4125            
Leu Ala Thr Ser Gly Gly Gln Ser Pro Thr Gly Glu Gln Ile Pro Gln
    4130                4135                4140                
Phe Gln Gln Arg Gln Lys Glu Leu Lys Lys Glu Val Met Glu His Arg
4145                4150                4155                4160
Leu Val Leu Asp Thr Val Asn Glu Val Ser Arg Ala Leu Leu Glu Leu
                4165                4170                4175    
Val Pro Trp Arg Ala Arg Glu Gly Leu Asp Lys Leu Val Ser Asp Ala
            4180                4185                4190        
Asn Glu Gln Tyr Lys Leu Val Ser Asp Thr Ile Gly Gln Arg Val Asp
        4195                4200                4205            
Glu Ile Asp Ala Ala Ile Gln Arg Ser Gln Gln Tyr Glu Gln Ala Ala
    4210                4215                4220                
Asp Ala Glu Leu Ala Trp Val Ala Glu Thr Lys Arg Lys Leu Met Ala
4225                4230                4235                4240
Leu Gly Pro Ile Arg Leu Glu Gln Asp Gln Thr Thr Ala Gln Leu Gln
                4245                4250                4255    
Val Gln Lys Ala Phe Ser Ile Asp Ile Ile Arg His Lys Asp Ser Met
            4260                4265                4270        
Asp Glu Leu Phe Ser His Arg Ser Glu Ile Phe Gly Thr Cys Gly Glu
        4275                4280                4285            
Glu Gln Lys Thr Val Leu Gln Glu Lys Thr Glu Ser Leu Ile Gln Gln
    4290                4295                4300                
Tyr Glu Ala Ile Ser Leu Leu Asn Ser Glu Arg Tyr Ala Arg Leu Glu
4305                4310                4315                4320
Arg Ala Gln Val Leu Val Asn Gln Phe Trp Glu Thr Tyr Glu Glu Leu
                4325                4330                4335    
Ser Pro Trp Ile Glu Glu Thr Arg Ala Leu Ile Ala Gln Leu Pro Ser
            4340                4345                4350        
Pro Ala Ile Asp His Glu Gln Leu Arg Gln Gln Gln Glu Glu Met Arg
        4355                4360                4365            
Gln Leu Arg Glu Ser Ile Ala Glu His Lys Pro His Ile Asp Lys Leu
    4370                4375                4380                
Leu Lys Ile Gly Pro Gln Leu Lys Glu Leu Asn Pro Glu Glu Gly Glu
4385                4390                4395                4400
Met Val Glu Glu Lys Tyr Gln Lys Ala Glu Asn Met Tyr Ala Gln Ile
                4405                4410                4415    
Lys Glu Glu Val Arg Gln Arg Ala Leu Ala Leu Asp Glu Ala Val Ser
            4420                4425                4430        
Gln Ser Thr Gln Ile Thr Glu Phe His Asp Lys Ile Glu Pro Met Leu
        4435                4440                4445            
Glu Thr Leu Glu Asn Leu Ser Ser Arg Leu Arg Met Pro Pro Leu Ile
    4450                4455                4460                
Pro Ala Glu Val Asp Lys Ile Arg Glu Cys Ile Ser Asp Asn Lys Ser
4465                4470                4475                4480
Ala Thr Val Glu Leu Glu Lys Leu Gln Pro Ser Phe Glu Ala Leu Lys
                4485                4490                4495    
Arg Arg Gly Glu Glu Leu Ile Gly Arg Ser Gln Gly Ala Asp Lys Asp
            4500                4505                4510        
Leu Ala Ala Lys Glu Ile Gln Asp Lys Leu Asp Gln Met Val Phe Phe
        4515                4520                4525            
Trp Glu Asp Ile Lys Ala Arg Ala Glu Glu Arg Glu Ile Lys Phe Leu
    4530                4535                4540                
Asp Val Leu Glu Leu Ala Glu Lys Phe Trp Tyr Asp Met Ala Ala Leu
4545                4550                4555                4560
Leu Thr Thr Ile Lys Asp Thr Gln Asp Ile Val His Asp Leu Glu Ser
                4565                4570                4575    
Pro Gly Ile Asp Pro Ser Ile Ile Lys Gln Gln Val Glu Ala Ala Glu
            4580                4585                4590        
Thr Ile Lys Glu Glu Thr Asp Gly Leu His Glu Glu Leu Glu Phe Ile
        4595                4600                4605            
Arg Ile Leu Gly Ala Asp Leu Ile Phe Ala Cys Gly Glu Thr Glu Lys
    4610                4615                4620                
Pro Glu Val Arg Lys Ser Ile Asp Glu Met Asn Asn Ala Trp Glu Asn
4625                4630                4635                4640
Leu Asn Lys Thr Trp Lys Glu Arg Leu Glu Lys Leu Glu Asp Ala Met
                4645                4650                4655    
Gln Ala Ala Val Gln Tyr Gln Asp Thr Leu Gln Ala Met Phe Asp Trp
            4660                4665                4670        
Leu Asp Asn Thr Val Ile Lys Leu Cys Thr Met Pro Pro Val Gly Thr
        4675                4680                4685            
Asp Leu Asn Thr Val Lys Asp Gln Leu Asn Glu Met Lys Glu Phe Lys
    4690                4695                4700                
Val Glu Val Tyr Gln Gln Gln Ile Glu Met Glu Lys Leu Asn His Gln
4705                4710                4715                4720
Gly Glu Leu Met Leu Lys Lys Ala Thr Asp Glu Thr Asp Arg Asp Ile
                4725                4730                4735    
Ile Arg Glu Pro Leu Thr Glu Leu Lys His Leu Trp Glu Asn Leu Gly
            4740                4745                4750        
Glu Lys Ile Ala His Arg Gln His Lys Leu Glu Gly Ala Leu Leu Ala
        4755                4760                4765            
Leu Gly Gln Phe Gln His Ala Leu Glu Glu Leu Met Ser Trp Leu Thr
    4770                4775                4780                
His Thr Glu Glu Leu Leu Asp Ala Gln Arg Pro Ile Ser Gly Asp Pro
4785                4790                4795                4800
Lys Val Ile Glu Val Glu Leu Ala Lys His His Val Leu Lys Asn Asp
                4805                4810                4815    
Val Leu Ala His Gln Ala Thr Val Glu Thr Val Asn Lys Ala Gly Asn
            4820                4825                4830        
Glu Leu Leu Glu Ser Ser Ala Gly Asp Asp Ala Ser Ser Leu Arg Ser
        4835                4840                4845            
Arg Leu Glu Ala Met Asn Gln Cys Trp Glu Ser Val Leu Gln Lys Thr
    4850                4855                4860                
Glu Glu Arg Glu Gln Gln Leu Gln Ser Thr Leu Gln Gln Ala Gln Gly
4865                4870                4875                4880
Phe His Ser Glu Ile Glu Asp Phe Leu Leu Glu Leu Thr Arg Met Glu
                4885                4890                4895    
Ser Gln Leu Ser Ala Ser Lys Pro Thr Gly Gly Leu Pro Glu Thr Ala
            4900                4905                4910        
Arg Glu Gln Leu Asp Thr His Met Glu Leu Tyr Ser Gln Leu Lys Ala
        4915                4920                4925            
Lys Glu Glu Thr Tyr Asn Gln Leu Leu Asp Lys Gly Arg Leu Met Leu
    4930                4935                4940                
Leu Ser Arg Asp Asp Ser Gly Ser Gly Ser Lys Thr Glu Gln Ser Val
4945                4950                4955                4960
Ala Leu Leu Glu Gln Lys Trp His Val Val Ser Ser Lys Met Glu Glu
                4965                4970                4975    
Arg Lys Ser Lys Leu Glu Glu Ala Leu Asn Leu Ala Thr Glu Phe Gln
            4980                4985                4990        
Asn Ser Leu Gln Glu Phe Ile Asn Trp Leu Thr Leu Ala Glu Gln Ser
        4995                5000                5005            
Leu Asn Ile Ala Ser Pro Pro Ser Leu Ile Leu Asn Thr Val Leu Ser
    5010                5015                5020                
Gln Ile Glu Glu His Lys Val Phe Ala Asn Glu Val Asn Ala His Arg
5025                5030                5035                5040
Asp Gln Ile Ile Glu Leu Asp Gln Thr Gly Asn Gln Leu Lys Phe Leu
                5045                5050                5055    
Ser Gln Lys Gln Asp Val Val Leu Ile Lys Asn Leu Leu Val Ser Val
            5060                5065                5070        
Gln Ser Arg Trp Glu Lys Val Val Gln Arg Ser Ile Glu Arg Gly Arg
        5075                5080                5085            
Ser Leu Asp Asp Ala Arg Lys Arg Ala Lys Gln Phe His Glu Ala Trp
    5090                5095                5100                
Lys Lys Leu Ile Asp Trp Leu Glu Asp Ala Glu Ser His Leu Asp Ser
5105                5110                5115                5120
Glu Leu Glu Ile Ser Asn Asp Pro Asp Lys Ile Lys Leu Gln Leu Ser
                5125                5130                5135    
Lys His Lys Glu Phe Gln Lys Thr Leu Gly Gly Lys Gln Pro Val Tyr
            5140                5145                5150        
Asp Thr Thr Ile Arg Thr Gly Arg Ala Leu Lys Glu Lys Thr Leu Leu
        5155                5160                5165            
Pro Glu Asp Thr Gln Lys Leu Asp Asn Phe Leu Gly Glu Val Arg Asp
    5170                5175                5180                
Lys Trp Asp Thr Val Cys Gly Lys Ser Val Glu Arg Gln His Lys Leu
5185                5190                5195                5200
Glu Glu Ala Leu Leu Phe Ser Gly Gln Phe Met Asp Ala Leu Gln Ala
                5205                5210                5215    
Leu Val Asp Trp Leu Tyr Lys Val Glu Pro Gln Leu Ala Glu Asp Gln
            5220                5225                5230        
Pro Val His Gly Asp Leu Asp Leu Val Met Asn Leu Met Asp Ala His
        5235                5240                5245            
Lys Val Phe Gln Lys Glu Leu Gly Lys Arg Thr Gly Thr Val Gln Val
    5250                5255                5260                
Leu Lys Arg Ser Gly Arg Glu Leu Ile Glu Asn Ser Arg Asp Asp Thr
5265                5270                5275                5280
Thr Trp Val Lys Gly Gln Leu Gln Glu Leu Ser Thr Arg Trp Asp Thr
                5285                5290                5295    
Val Cys Lys Leu Ser Val Ser Lys Gln Ser Arg Leu Glu Gln Ala Leu
            5300                5305                5310        
Lys Gln Ala Glu Val Phe Arg Asp Thr Val His Met Leu Leu Glu Trp
        5315                5320                5325            
Leu Ser Glu Ala Glu Gln Thr Leu Arg Phe Arg Gly Ala Leu Pro Asp
    5330                5335                5340                
Asp Thr Glu Ala Leu Gln Ser Leu Ile Asp Thr His Lys Glu Phe Met
5345                5350                5355                5360
Lys Lys Val Glu Glu Lys Arg Val Asp Val Asn Ser Ala Val Ala Met
                5365                5370                5375    
Gly Glu Val Ile Leu Ala Val Cys His Pro Asp Cys Ile Thr Thr Ile
            5380                5385                5390        
Lys His Trp Ile Thr Ile Ile Arg Ala Arg Phe Glu Glu Val Leu Thr
        5395                5400                5405            
Trp Ala Lys Gln His Gln Gln Arg Leu Glu Thr Ala Leu Ser Glu Leu
    5410                5415                5420                
Val Ala Asn Ala Glu Leu Leu Glu Glu Leu Leu Ala Trp Ile Gln Trp
5425                5430                5435                5440
Ala Glu Thr Thr Leu Ile Gln Arg Asp Gln Glu Pro Ile Pro Gln Asn
                5445                5450                5455    
Ile Asp Arg Val Lys Ala Leu Ile Ala Glu His Gln Thr Phe Met Glu
            5460                5465                5470        
Glu Met Thr Arg Lys Gln Pro Asp Val Asp Arg Val Thr Lys Thr Tyr
        5475                5480                5485            
Lys Arg Lys Asn Ile Glu Pro Thr His Ala Pro Phe Ile Glu Lys Ser
    5490                5495                5500                
Arg Ser Gly Gly Arg Lys Ser Leu Ser Gln Pro Thr Pro Pro Pro Met
5505                5510                5515                5520
Pro Ile Leu Ser Gln Ser Glu Ala Lys Asn Pro Arg Ile Asn Gln Leu
                5525                5530                5535    
Ser Ala Arg Trp Gln Gln Val Trp Leu Leu Ala Leu Glu Arg Gln Arg
            5540                5545                5550        
Lys Leu Asn Asp Ala Leu Asp Arg Leu Glu Glu Leu Lys Glu Phe Ala
        5555                5560                5565            
Asn Phe Asp Phe Asp Val Trp Arg Lys Lys Tyr Met Arg Trp Met Asn
    5570                5575                5580                
His Lys Lys Ser Arg Val Met Asp Phe Phe Arg Arg Ile Asp Lys Asp
5585                5590                5595                5600
Gln Asp Gly Lys Ile Thr Arg Gln Glu Phe Ile Asp Gly Ile Leu Ala
                5605                5610                5615    
Ser Lys Phe Pro Thr Thr Lys Leu Glu Met Thr Ala Val Ala Asp Ile
            5620                5625                5630        
Phe Asp Arg Asp Gly Asp Gly Tyr Ile Asp Tyr Tyr Glu Phe Val Ala
        5635                5640                5645            
Ala Leu His Pro Asn Lys Asp Ala Tyr Arg Pro Thr Thr Asp Ala Asp
    5650                5655                5660                
Lys Ile Glu Asp Glu Val Thr Arg Gln Val Ala Gln Cys Lys Cys Ala
5665                5670                5675                5680
Lys Arg Phe Gln Val Glu Gln Ile Gly Glu Asn Lys Tyr Arg Phe Phe
                5685                5690                5695    
Leu Gly Asn Gln Phe Gly Asp Ser Gln Gln Leu Arg Leu Val Arg Ile
            5700                5705                5710        
Leu Arg Ser Thr Val Met Val Arg Val Gly Gly Gly Trp Met Ala Leu
        5715                5720                5725            
Asp Glu Phe Leu Val Lys Asn Asp Pro Cys Arg Ala Arg Gly Arg Thr
    5730                5735                5740                
Asn Ile Glu Leu Arg Glu Lys Phe Ile Leu Pro Glu Gly Ala Ser Gln
5745                5750                5755                5760
Gly Met Thr Pro Phe Arg Ser Arg Gly Arg Arg Ser Lys Pro Ser Ser
                5765                5770                5775    
Arg Ala Ala Ser Pro Thr Arg Ser Ser Ser Ser Ala Ser Gln Ser Asn
            5780                5785                5790        
His Ser Cys Thr Ser Met Pro Ser Ser Pro Ala Thr Pro Ala Ser Gly
        5795                5800                5805            
Thr Lys Val Ile Pro Ser Ser Gly Ser Lys Leu Lys Arg Pro Thr Pro
    5810                5815                5820                
Thr Phe His Ser Ser Arg Thr Ser Leu Ala Gly Asp Thr Ser Asn Ser
5825                5830                5835                5840
Ser Ser Pro Ala Ser Thr Gly Ala Lys Thr Asn Arg Ala Asp Pro Lys
                5845                5850                5855    
Lys Ser Ala Ser Arg Pro Gly Ser Arg Ala Gly Ser Arg Ala Gly Ser
            5860                5865                5870        
Arg Ala Ser Ser Arg Arg Gly Ser Asp Ala Ser Asp Phe Asp Leu Leu
        5875                5880                5885            
Glu Thr Gln Ser Ala Cys Ser Asp Thr Ser Glu Ser Ser Ala Ala Gly
    5890                5895                5900                
Gly Gln Gly Asn Ser Arg Arg Gly Leu Asn Lys Pro Ser Lys Ile Pro
5905                5910                5915                5920
Thr Met Ser Lys Lys Thr Thr Thr Ala Ser Pro Arg Thr Pro Gly Pro
                5925                5930                5935    
Lys Arg
        


<210> 6058
<211> 5430
<212> PRT
<213> Homo sapiens

<400> 6058
Met Ser Ser Ser Asp Glu Glu Thr Leu Ser Glu Arg Ser Cys Arg Ser
 1               5                  10                  15      
Glu Arg Ser Cys Arg Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly
            20                  25                  30          
Ser Leu Ser Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro
        35                  40                  45              
Leu His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro
    50                  55                  60                  
Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln
65                  70                  75                  80  
Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg
                85                  90                  95      
Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu
            100                 105                 110         
Ile Ser Leu Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys
        115                 120                 125             
Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp
    130                 135                 140                 
Phe Leu Lys Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp
145                 150                 155                 160 
Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile
                165                 170                 175     
Ile Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly
            180                 185                 190         
Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr
        195                 200                 205             
Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser
    210                 215                 220                 
Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu
225                 230                 235                 240 
Val Asp Met Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu
                245                 250                 255     
Gln Ala Phe Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp
            260                 265                 270         
Ala Glu Asp Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr
        275                 280                 285             
Tyr Val Ser Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly
    290                 295                 300                 
Glu Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln
305                 310                 315                 320 
Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu
                325                 330                 335     
Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu
            340                 345                 350         
Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu
        355                 360                 365             
Arg Glu Lys Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp
    370                 375                 380                 
Ile Glu Phe Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp
385                 390                 395                 400 
Val Glu Glu Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu
                405                 410                 415     
Lys Ser Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile
            420                 425                 430         
Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr
        435                 440                 445             
Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly
    450                 455                 460                 
Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys
465                 470                 475                 480 
Glu Gly Leu Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp
                485                 490                 495     
Glu Asn Tyr Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu
            500                 505                 510         
Gln Asp Glu Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg
        515                 520                 525             
Lys Gly His Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr
    530                 535                 540                 
Thr Thr His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser
545                 550                 555                 560 
Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala
                565                 570                 575     
Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu
            580                 585                 590         
Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp
        595                 600                 605             
Gly Asn Asp Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His
    610                 615                 620                 
Ile His Thr Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg
625                 630                 635                 640 
Leu Tyr Glu Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu
                645                 650                 655     
Thr Leu Gly Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser
            660                 665                 670         
Ser Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg
        675                 680                 685             
Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu
    690                 695                 700                 
Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn
705                 710                 715                 720 
Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe
                725                 730                 735     
Arg Ser Leu Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro
            740                 745                 750         
Ala Lys Gln Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu
        755                 760                 765             
Gln Trp Met Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu
    770                 775                 780                 
Asn Thr Ala Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser
785                 790                 795                 800 
Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp
                805                 810                 815     
His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met
            820                 825                 830         
Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu
        835                 840                 845             
Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp
    850                 855                 860                 
His Val Leu Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg
865                 870                 875                 880 
Gln Ile Glu Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp
                885                 890                 895     
Asn Ser Gln Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu
            900                 905                 910         
Ala Met Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp
        915                 920                 925             
Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met
    930                 935                 940                 
Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp
945                 950                 955                 960 
Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu
                965                 970                 975     
Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn
            980                 985                 990         
Leu Gln Ala His Tyr Glu Asp Phe Leu Gln Asp Ser Arg Asp Ser Val
        995                 1000                1005            
Leu Phe Ser Val Ala Asp Arg Leu Arg Leu Glu Glu Glu Val Glu Ala
    1010                1015                1020                
Cys Lys Ala Arg Phe Gln His Leu Met Lys Ser Met Glu Asn Glu Asp
1025                1030                1035                1040
Lys Glu Glu Thr Val Ala Lys Met Tyr Ile Ser Glu Leu Lys Asn Ile
                1045                1050                1055    
Arg Leu Arg Leu Glu Glu Tyr Glu Gln Arg Val Val Lys Arg Ile Gln
            1060                1065                1070        
Ser Leu Ala Ser Ser Arg Thr Asp Arg Asp Ala Trp Gln Asp Asn Ala
        1075                1080                1085            
Leu Arg Ile Ala Glu Gln Glu His Thr Gln Glu Asp Leu Gln Gln Leu
    1090                1095                1100                
Arg Ser Asp Leu Asp Ala Val Ser Met Lys Cys Asp Ser Phe Leu His
1105                1110                1115                1120
Gln Ser Pro Ser Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn
                1125                1130                1135    
Leu Leu Val Glu Lys Met Asp His Val Tyr Gly Leu Ser Thr Val Tyr
            1140                1145                1150        
Leu Asn Lys Leu Lys Thr Val Asp Val Ile Val Arg Ser Ile Gln Asp
        1155                1160                1165            
Ala Glu Leu Leu Val Lys Gly Tyr Glu Ile Lys Leu Ser Gln Glu Glu
    1170                1175                1180                
Val Val Leu Ala Asp Leu Ser Ala Leu Glu Ala His Trp Ser Thr Leu
1185                1190                1195                1200
Arg His Trp Leu Ser Asp Val Lys Asp Lys Asn Ser Val Phe Ser Val
                1205                1210                1215    
Leu Asp Glu Glu Ile Ala Lys Ala Lys Val Val Ala Glu Gln Met Ser
            1220                1225                1230        
Arg Leu Thr Pro Glu Arg Asn Leu Asp Leu Glu Arg Tyr Gln Glu Lys
        1235                1240                1245            
Gly Ser Gln Leu Gln Glu Arg Trp His Arg Val Ile Ala Gln Leu Glu
    1250                1255                1260                
Ile Arg Gln Ser Glu Leu Glu Ser Ile Gln Glu Val Leu Gly Asp Tyr
1265                1270                1275                1280
Arg Ala Cys His Gly Thr Leu Ile Lys Trp Ile Glu Glu Thr Thr Ala
                1285                1290                1295    
Gln Gln Glu Met Met Lys Pro Gly Gln Ala Glu Asp Ser Arg Val Leu
            1300                1305                1310        
Ser Glu Gln Leu Ser Gln Gln Thr Ala Leu Phe Ala Glu Ile Glu Arg
        1315                1320                1325            
Asn Gln Thr Lys Leu Asp Gln Cys Gln Lys Phe Ser Gln Gln Tyr Ser
    1330                1335                1340                
Thr Ile Val Lys Asp Tyr Glu Leu Gln Leu Met Thr Tyr Lys Ala Phe
1345                1350                1355                1360
Val Glu Ser Gln Gln Lys Ser Pro Gly Lys Arg Arg Arg Met Leu Ser
                1365                1370                1375    
Ser Ser Asp Ala Ile Thr Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr
            1380                1385                1390        
Thr Ala Leu Val Thr Leu Thr Thr Gln His Val Lys Tyr Ile Ser Asp
        1395                1400                1405            
Ala Leu Arg Arg Leu Glu Glu Glu Glu Lys Val Val Glu Glu Glu Lys
    1410                1415                1420                
Gln Glu His Val Glu Lys Val Lys Glu Leu Leu Gly Trp Val Ser Thr
1425                1430                1435                1440
Leu Ala Arg Asn Thr Gln Gly Lys Ala Thr Ser Ser Glu Thr Lys Glu
                1445                1450                1455    
Ser Thr Asp Ile Glu Lys Ala Ile Leu Glu Gln Gln Val Leu Ser Glu
            1460                1465                1470        
Glu Leu Thr Thr Lys Lys Glu Gln Val Ser Glu Ala Ile Lys Ala Ser
        1475                1480                1485            
Gln Ile Phe Leu Ala Lys His Gly His Lys Leu Ser Glu Lys Glu Lys
    1490                1495                1500                
Lys Gln Ile Ser Glu Gln Leu Asn Ala Leu Asn Lys Ala Tyr His Asp
1505                1510                1515                1520
Leu Cys Asp Gly Ser Ala Asn Gln Leu Gln Gln Leu Gln Ser Gln Leu
                1525                1530                1535    
Ala His Gln Thr Glu Gln Lys Thr Leu Gln Lys Gln Gln Asn Thr Cys
            1540                1545                1550        
His Gln Gln Leu Glu Asp Leu Cys Ser Trp Val Gly Gln Ala Glu Arg
        1555                1560                1565            
Ala Leu Ala Gly His Gln Gly Arg Thr Thr Gln Gln Asp Leu Ser Ala
    1570                1575                1580                
Leu Gln Lys Asn Gln Ser Asp Leu Lys Asp Leu Gln Asp Asp Ile Gln
1585                1590                1595                1600
Asn Arg Ala Thr Ser Phe Ala Thr Val Val Lys Asp Ile Glu Gly Phe
                1605                1610                1615    
Met Glu Glu Asn Gln Thr Lys Leu Ser Pro Arg Glu Leu Thr Ala Leu
            1620                1625                1630        
Arg Glu Lys Leu His Gln Ala Lys Glu Gln Tyr Glu Ala Leu Gln Glu
        1635                1640                1645            
Glu Thr Arg Val Ala Gln Lys Glu Leu Glu Glu Ala Val Thr Ser Ala
    1650                1655                1660                
Leu Gln Gln Glu Thr Glu Lys Ser Lys Ala Ala Lys Glu Leu Ala Glu
1665                1670                1675                1680
Asn Lys Lys Lys Ile Asp Ala Leu Leu Asp Trp Val Thr Ser Val Gly
                1685                1690                1695    
Ser Ser Gly Gly Gln Leu Leu Thr Asn Leu Pro Gly Met Glu Gln Leu
            1700                1705                1710        
Ser Gly Ala Ser Leu Glu Lys Gly Ala Leu Asp Thr Thr Asp Gly Tyr
        1715                1720                1725            
Met Gly Val Asn Gln Ala Pro Glu Lys Leu Asp Lys Gln Cys Glu Met
    1730                1735                1740                
Met Lys Ala Arg His Gln Glu Leu Leu Ser Gln Gln Gln Asn Phe Ile
1745                1750                1755                1760
Leu Ala Thr Gln Ser Ala Gln Ala Phe Leu Asp Gln His Gly His Asn
                1765                1770                1775    
Leu Thr Pro Glu Glu Gln Gln Met Leu Gln Gln Lys Leu Gly Glu Leu
            1780                1785                1790        
Lys Glu Gln Tyr Ser Thr Ser Leu Ala Gln Ser Glu Ala Glu Leu Lys
        1795                1800                1805            
Gln Val Gln Thr Leu Gln Asp Glu Leu Gln Lys Phe Leu Gln Asp His
    1810                1815                1820                
Lys Glu Phe Glu Ser Trp Leu Glu Arg Ser Glu Lys Glu Leu Glu Asn
1825                1830                1835                1840
Met His Lys Gly Gly Ser Ser Pro Glu Thr Leu Pro Ser Leu Leu Lys
                1845                1850                1855    
Arg Gln Gly Ser Phe Ser Glu Asp Val Ile Ser His Lys Gly Asp Leu
            1860                1865                1870        
Arg Phe Val Thr Ile Ser Gly Gln Lys Val Leu Asp Met Glu Asn Ser
        1875                1880                1885            
Phe Lys Glu Gly Lys Glu Pro Ser Glu Ile Gly Asn Leu Val Lys Asp
    1890                1895                1900                
Lys Leu Lys Asp Ala Thr Glu Arg Tyr Thr Ala Leu His Ser Lys Cys
1905                1910                1915                1920
Thr Arg Leu Gly Ser His Leu Asn Met Leu Leu Gly Gln Tyr His Gln
                1925                1930                1935    
Phe Gln Asn Ser Ala Asp Ser Leu Gln Ala Trp Met Gln Ala Cys Glu
            1940                1945                1950        
Ala Asn Val Glu Lys Leu Leu Ser Asp Thr Val Ala Ser Asp Pro Gly
        1955                1960                1965            
Val Leu Gln Glu Gln Leu Ala Thr Thr Lys Gln Leu Gln Glu Glu Leu
    1970                1975                1980                
Ala Glu His Gln Val Pro Val Glu Lys Leu Gln Lys Val Ala Arg Asp
1985                1990                1995                2000
Ile Met Glu Ile Glu Gly Glu Pro Ala Pro Asp His Arg His Val Gln
                2005                2010                2015    
Glu Thr Thr Asp Ser Ile Leu Ser His Phe Gln Ser Leu Ser Tyr Ser
            2020                2025                2030        
Leu Ala Glu Arg Ser Ser Leu Leu Gln Lys Ala Ile Ala Gln Ser Gln
        2035                2040                2045            
Ser Val Gln Glu Ser Leu Glu Ser Leu Leu Gln Ser Ile Gly Glu Val
    2050                2055                2060                
Glu Gln Asn Leu Glu Gly Lys Gln Val Ser Ser Leu Ser Ser Gly Val
2065                2070                2075                2080
Ile Gln Glu Ala Leu Ala Thr Asn Met Lys Leu Lys Gln Asp Ile Ala
                2085                2090                2095    
Arg Gln Lys Ser Ser Leu Glu Ala Thr Arg Glu Met Val Thr Arg Phe
            2100                2105                2110        
Met Glu Thr Ala Asp Ser Thr Thr Ala Ala Val Leu Gln Gly Lys Leu
        2115                2120                2125            
Ala Glu Val Ser Gln Arg Phe Glu Gln Leu Cys Leu Gln Gln Gln Glu
    2130                2135                2140                
Lys Glu Ser Ser Leu Lys Lys Leu Leu Pro Gln Ala Glu Met Phe Glu
2145                2150                2155                2160
His Leu Ser Gly Lys Leu Gln Gln Phe Met Glu Asn Lys Ser Arg Met
                2165                2170                2175    
Leu Ala Ser Gly Asn Gln Pro Asp Gln Asp Ile Thr His Phe Phe Gln
            2180                2185                2190        
Gln Ile Gln Glu Leu Asn Leu Glu Met Glu Asp Gln Gln Glu Asn Leu
        2195                2200                2205            
Asp Thr Leu Glu His Leu Val Thr Glu Leu Ser Ser Cys Gly Phe Ala
    2210                2215                2220                
Leu Asp Leu Cys Gln His Gln Asp Arg Val Gln Asn Leu Arg Lys Asp
2225                2230                2235                2240
Phe Thr Glu Leu Gln Lys Thr Val Lys Glu Arg Glu Lys Asp Ala Ser
                2245                2250                2255    
Ser Cys Gln Glu Gln Leu Asp Glu Phe Arg Lys Leu Val Arg Thr Phe
            2260                2265                2270        
Gln Lys Trp Leu Lys Glu Thr Glu Gly Ser Ile Pro Pro Thr Glu Thr
        2275                2280                2285            
Ser Met Ser Ala Lys Glu Leu Glu Lys Gln Ile Glu His Leu Lys Ser
    2290                2295                2300                
Leu Leu Asp Asp Trp Ala Ser Lys Gly Thr Leu Val Glu Glu Ile Asn
2305                2310                2315                2320
Cys Lys Gly Thr Ser Leu Glu Asn Leu Ile Met Glu Ile Thr Ala Pro
                2325                2330                2335    
Asp Ser Gln Gly Lys Thr Gly Ser Ile Leu Pro Ser Val Gly Ser Ser
            2340                2345                2350        
Val Gly Ser Val Asn Gly Tyr His Thr Cys Lys Asp Leu Thr Glu Ile
        2355                2360                2365            
Gln Cys Asp Met Ser Asp Val Asn Leu Lys Tyr Glu Lys Leu Gly Gly
    2370                2375                2380                
Val Leu His Glu Arg Gln Glu Ser Leu Gln Ala Ile Leu Asn Arg Met
2385                2390                2395                2400
Glu Glu Val His Lys Glu Ala Asn Ser Val Leu Gln Trp Leu Glu Ser
                2405                2410                2415    
Lys Glu Glu Val Leu Lys Ser Met Asp Ala Met Ser Ser Pro Thr Lys
            2420                2425                2430        
Thr Glu Thr Val Lys Ala Gln Ala Glu Ser Asn Lys Ala Phe Leu Ala
        2435                2440                2445            
Glu Leu Glu Gln Asn Ser Pro Lys Ile Gln Lys Val Lys Glu Ala Leu
    2450                2455                2460                
Ala Gly Leu Leu Val Thr Tyr Pro Asn Ser Gln Glu Ala Glu Asn Trp
2465                2470                2475                2480
Lys Lys Ile Gln Glu Glu Leu Asn Ser Arg Trp Glu Arg Ala Thr Glu
                2485                2490                2495    
Val Thr Val Ala Arg Gln Arg Gln Leu Glu Glu Ser Ala Ser His Leu
            2500                2505                2510        
Ala Cys Phe Gln Ala Ala Glu Ser Gln Leu Gln Pro Trp Leu Met Glu
        2515                2520                2525            
Lys Glu Leu Met Met Gly Val Leu Gly Pro Leu Ser Ile Asp Pro Asn
    2530                2535                2540                
Met Leu Asn Ala Gln Lys Gln Gln Val Gln Phe Met Leu Lys Glu Phe
2545                2550                2555                2560
Glu Ala Arg Arg Gln Gln His Glu Gln Leu Asn Glu Ala Ala Gln Gly
                2565                2570                2575    
Ile Leu Thr Gly Pro Gly Asp Val Ser Leu Ser Thr Ser Gln Val Gln
            2580                2585                2590        
Lys Glu Leu Gln Ser Ile Asn Gln Lys Trp Val Glu Leu Thr Asp Lys
        2595                2600                2605            
Leu Asn Ser Arg Ser Ser Gln Ile Asp Gln Ala Ile Val Lys Ser Thr
    2610                2615                2620                
Gln Tyr Gln Glu Leu Leu Gln Asp Leu Ser Glu Lys Val Arg Ala Val
2625                2630                2635                2640
Gly Gln Arg Leu Ser Val Gln Ser Ala Ile Ser Thr Gln Pro Glu Ala
                2645                2650                2655    
Val Lys Gln Gln Leu Glu Glu Thr Ser Glu Ile Arg Ser Asp Leu Glu
            2660                2665                2670        
Gln Leu Asp His Glu Val Lys Glu Ala Gln Thr Leu Cys Asp Glu Leu
        2675                2680                2685            
Ser Val Leu Ile Gly Glu Gln Tyr Leu Lys Asp Glu Leu Lys Lys Arg
    2690                2695                2700                
Leu Glu Thr Val Ala Leu Pro Leu Gln Gly Leu Glu Asp Leu Ala Ala
2705                2710                2715                2720
Asp Arg Ile Asn Arg Leu Gln Ala Ala Leu Ala Ser Thr Gln Gln Phe
                2725                2730                2735    
Gln Gln Met Phe Asp Glu Leu Arg Thr Trp Leu Asp Asp Lys Gln Ser
            2740                2745                2750        
Gln Gln Ala Lys Asn Cys Pro Ile Ser Ala Lys Leu Glu Arg Leu Gln
        2755                2760                2765            
Ser Gln Leu Gln Glu Asn Glu Glu Phe Gln Lys Ser Leu Asn Gln His
    2770                2775                2780                
Ser Gly Ser Tyr Glu Val Ile Val Ala Glu Gly Glu Ser Leu Leu Leu
2785                2790                2795                2800
Ser Val Pro Pro Gly Glu Glu Lys Arg Thr Leu Gln Asn Gln Leu Val
                2805                2810                2815    
Glu Leu Lys Asn His Trp Glu Glu Leu Ser Lys Lys Thr Ala Asp Arg
            2820                2825                2830        
Gln Ser Arg Leu Lys Asp Cys Met Gln Lys Ala Gln Lys Tyr Gln Trp
        2835                2840                2845            
His Val Glu Asp Leu Val Pro Trp Ile Glu Asp Cys Lys Ala Lys Met
    2850                2855                2860                
Ser Glu Leu Arg Val Thr Leu Asp Pro Val Gln Leu Glu Ser Ser Leu
2865                2870                2875                2880
Leu Arg Ser Lys Ala Met Leu Asn Glu Val Glu Lys Arg Arg Ser Leu
                2885                2890                2895    
Leu Glu Ile Leu Asn Ser Ala Ala Asp Ile Leu Ile Asn Ser Ser Glu
            2900                2905                2910        
Ala Asp Glu Asp Gly Ile Arg Asp Glu Lys Ala Gly Ile Asn Gln Asn
        2915                2920                2925            
Met Asp Ala Val Thr Glu Glu Leu Gln Ala Lys Thr Gly Ser Leu Glu
    2930                2935                2940                
Glu Met Thr Gln Arg Leu Arg Glu Phe Gln Glu Ser Phe Lys Asn Ile
2945                2950                2955                2960
Glu Lys Lys Val Glu Gly Ala Lys His Gln Leu Glu Ile Phe Asp Ala
                2965                2970                2975    
Leu Gly Ser Gln Ala Cys Ser Asn Lys Asn Leu Glu Lys Leu Arg Ala
            2980                2985                2990        
Gln Gln Glu Val Leu Gln Ala Leu Glu Pro Gln Val Asp Tyr Leu Arg
        2995                3000                3005            
Asn Phe Thr Gln Gly Leu Val Glu Asp Ala Pro Asp Gly Ser Asp Ala
    3010                3015                3020                
Ser Gln Leu Leu His Gln Ala Glu Val Ala Gln Gln Glu Phe Leu Glu
3025                3030                3035                3040
Val Lys Gln Arg Val Asn Ser Gly Cys Val Met Met Glu Asn Lys Leu
                3045                3050                3055    
Glu Gly Ile Gly Gln Phe His Cys Arg Val Arg Glu Met Phe Ser Gln
            3060                3065                3070        
Leu Ala Asp Leu Asp Asp Glu Leu Asp Gly Met Gly Ala Ile Gly Arg
        3075                3080                3085            
Asp Thr Asp Ser Leu Gln Ser Gln Ile Glu Asp Val Arg Leu Phe Leu
    3090                3095                3100                
Asn Lys Ile His Val Leu Lys Leu Asp Ile Glu Ala Ser Glu Ala Glu
3105                3110                3115                3120
Cys Arg His Met Leu Glu Glu Glu Gly Thr Leu Asp Leu Leu Gly Leu
                3125                3130                3135    
Lys Arg Glu Leu Glu Ala Leu Asn Lys Gln Cys Gly Lys Leu Thr Glu
            3140                3145                3150        
Arg Gly Lys Ala Arg Gln Glu Gln Leu Glu Leu Thr Leu Gly Arg Val
        3155                3160                3165            
Glu Asp Phe Tyr Arg Lys Leu Lys Gly Leu Asn Asp Ala Thr Thr Ala
    3170                3175                3180                
Ala Glu Glu Ala Glu Ala Leu Gln Trp Val Val Gly Thr Glu Val Glu
3185                3190                3195                3200
Ile Ile Asn Gln Gln Leu Ala Asp Phe Lys Met Phe Gln Lys Glu Gln
                3205                3210                3215    
Val Asp Pro Leu Gln Met Lys Leu Gln Gln Val Asn Gly Leu Gly Gln
            3220                3225                3230        
Gly Leu Ile Gln Ser Ala Gly Lys Asp Cys Asp Val Gln Gly Leu Glu
        3235                3240                3245            
His Asp Met Glu Glu Ile Asn Ala Arg Trp Asn Thr Leu Asn Lys Lys
    3250                3255                3260                
Val Ala Gln Arg Ile Ala Gln Leu Gln Glu Ala Leu Leu His Cys Gly
3265                3270                3275                3280
Lys Phe Gln Asp Ala Leu Glu Pro Leu Leu Ser Trp Leu Ala Asp Thr
                3285                3290                3295    
Glu Glu Leu Ile Ala Asn Gln Lys Pro Pro Ser Ala Glu Tyr Lys Val
            3300                3305                3310        
Val Lys Ala Gln Ile Gln Glu Gln Lys Leu Leu Gln Arg Leu Leu Asp
        3315                3320                3325            
Asp Arg Lys Ala Thr Val Asp Met Leu Gln Ala Glu Gly Gly Arg Ile
    3330                3335                3340                
Ala Gln Ser Ala Glu Leu Ala Asp Arg Glu Lys Ile Thr Gly Gln Leu
3345                3350                3355                3360
Glu Ser Leu Glu Ser Arg Trp Thr Glu Leu Leu Ser Lys Ala Ala Ala
                3365                3370                3375    
Arg Gln Lys Gln Leu Glu Asp Ile Leu Val Leu Ala Lys Gln Phe His
            3380                3385                3390        
Glu Thr Ala Glu Pro Ile Ser Asp Phe Leu Ser Val Thr Glu Lys Lys
        3395                3400                3405            
Leu Ala Asn Ser Glu Pro Val Gly Thr Gln Thr Ala Lys Ile Gln Gln
    3410                3415                3420                
Gln Ile Ile Arg His Lys Ala Leu Glu Glu Asp Ile Glu Asn His Ala
3425                3430                3435                3440
Thr Asp Val His Gln Ala Val Lys Ile Gly Gln Ser Leu Ser Ser Leu
                3445                3450                3455    
Thr Ser Pro Ala Glu Gln Gly Val Leu Ser Glu Lys Ile Asp Ser Leu
            3460                3465                3470        
Gln Ala Arg Tyr Ser Glu Ile Gln Asp Arg Cys Cys Arg Lys Ala Ala
        3475                3480                3485            
Leu Leu Asp Gln Ala Leu Ser Asn Ala Arg Leu Phe Gly Glu Asp Glu
    3490                3495                3500                
Val Glu Val Leu Asn Trp Leu Ala Glu Val Glu Asp Lys Leu Ser Ser
3505                3510                3515                3520
Val Phe Val Lys Asp Phe Lys Gln Asp Val Leu His Arg Gln His Ala
                3525                3530                3535    
Asp His Leu Ala Leu Asn Glu Glu Ile Val Asn Arg Lys Lys Asn Val
            3540                3545                3550        
Asp Gln Ala Ile Lys Asn Gly Gln Ala Leu Leu Lys Gln Thr Thr Gly
        3555                3560                3565            
Glu Glu Val Leu Leu Ile Gln Glu Lys Leu Asp Gly Ile Lys Thr Arg
    3570                3575                3580                
Tyr Ala Asp Ile Thr Val Thr Ser Ser Lys Ala Leu Arg Thr Leu Glu
3585                3590                3595                3600
Gln Ala Arg Gln Leu Ala Thr Lys Phe Gln Ser Thr Tyr Glu Glu Leu
                3605                3610                3615    
Thr Gly Trp Leu Arg Glu Val Glu Glu Glu Leu Ala Thr Ser Gly Gly
            3620                3625                3630        
Gln Ser Pro Thr Gly Glu Gln Ile Pro Gln Phe Gln Gln Arg Gln Lys
        3635                3640                3645            
Glu Leu Lys Lys Glu Val Met Glu His Arg Leu Val Leu Asp Thr Val
    3650                3655                3660                
Asn Glu Val Ser Arg Ala Leu Leu Glu Leu Val Pro Trp Arg Ala Arg
3665                3670                3675                3680
Glu Gly Leu Asp Lys Leu Val Ser Asp Ala Asn Glu Gln Tyr Lys Leu
                3685                3690                3695    
Val Ser Asp Thr Ile Gly Gln Arg Val Asp Glu Ile Asp Ala Ala Ile
            3700                3705                3710        
Gln Arg Ser Gln Gln Tyr Glu Gln Ala Ala Asp Ala Glu Leu Ala Trp
        3715                3720                3725            
Val Ala Glu Thr Lys Arg Lys Leu Met Ala Leu Gly Pro Ile Arg Leu
    3730                3735                3740                
Glu Gln Asp Gln Thr Thr Ala Gln Leu Gln Val Gln Lys Ala Phe Ser
3745                3750                3755                3760
Ile Asp Ile Ile Arg His Lys Asp Ser Met Asp Glu Leu Phe Ser His
                3765                3770                3775    
Arg Ser Glu Ile Phe Gly Thr Cys Gly Glu Glu Gln Lys Thr Val Leu
            3780                3785                3790        
Gln Glu Lys Thr Glu Ser Leu Ile Gln Gln Tyr Glu Ala Ile Ser Leu
        3795                3800                3805            
Leu Asn Ser Glu Arg Tyr Ala Arg Leu Glu Arg Ala Gln Val Leu Val
    3810                3815                3820                
Asn Gln Phe Trp Glu Thr Tyr Glu Glu Leu Ser Pro Trp Ile Glu Glu
3825                3830                3835                3840
Thr Arg Ala Leu Ile Ala Gln Leu Pro Ser Pro Ala Ile Asp His Glu
                3845                3850                3855    
Gln Leu Arg Gln Gln Gln Glu Glu Met Arg Gln Leu Arg Glu Ser Ile
            3860                3865                3870        
Ala Glu His Lys Pro His Ile Asp Lys Leu Leu Lys Ile Gly Pro Gln
        3875                3880                3885            
Leu Lys Glu Leu Asn Pro Glu Glu Gly Glu Met Val Glu Glu Lys Tyr
    3890                3895                3900                
Gln Lys Ala Glu Asn Met Tyr Ala Gln Ile Lys Glu Glu Val Arg Gln
3905                3910                3915                3920
Arg Ala Leu Ala Leu Asp Glu Ala Val Ser Gln Ser Thr Gln Ile Thr
                3925                3930                3935    
Glu Phe His Asp Lys Ile Glu Pro Met Leu Glu Thr Leu Glu Asn Leu
            3940                3945                3950        
Ser Ser Arg Leu Arg Met Pro Pro Leu Ile Pro Ala Glu Val Asp Lys
        3955                3960                3965            
Ile Arg Glu Cys Ile Ser Asp Asn Lys Ser Ala Thr Val Glu Leu Glu
    3970                3975                3980                
Lys Leu Gln Pro Ser Phe Glu Ala Leu Lys Arg Arg Gly Glu Glu Leu
3985                3990                3995                4000
Ile Gly Arg Ser Gln Gly Ala Asp Lys Asp Leu Ala Ala Lys Glu Ile
                4005                4010                4015    
Gln Asp Lys Leu Asp Gln Met Val Phe Phe Trp Glu Asp Ile Lys Ala
            4020                4025                4030        
Arg Ala Glu Glu Arg Glu Ile Lys Phe Leu Asp Val Leu Glu Leu Ala
        4035                4040                4045            
Glu Lys Phe Trp Tyr Asp Met Ala Ala Leu Leu Thr Thr Ile Lys Asp
    4050                4055                4060                
Thr Gln Asp Ile Val His Asp Leu Glu Ser Pro Gly Ile Asp Pro Ser
4065                4070                4075                4080
Ile Ile Lys Gln Gln Val Glu Ala Ala Glu Thr Ile Lys Glu Glu Thr
                4085                4090                4095    
Asp Gly Leu His Glu Glu Leu Glu Phe Ile Arg Ile Leu Gly Ala Asp
            4100                4105                4110        
Leu Ile Phe Ala Cys Gly Glu Thr Glu Lys Pro Glu Val Arg Lys Ser
        4115                4120                4125            
Ile Asp Glu Met Asn Asn Ala Trp Glu Asn Leu Asn Lys Thr Trp Lys
    4130                4135                4140                
Glu Arg Leu Glu Lys Leu Glu Asp Ala Met Gln Ala Ala Val Gln Tyr
4145                4150                4155                4160
Gln Asp Thr Leu Gln Ala Met Phe Asp Trp Leu Asp Asn Thr Val Ile
                4165                4170                4175    
Lys Leu Cys Thr Met Pro Pro Val Gly Thr Asp Leu Asn Thr Val Lys
            4180                4185                4190        
Asp Gln Leu Asn Glu Met Lys Glu Phe Lys Val Glu Val Tyr Gln Gln
        4195                4200                4205            
Gln Ile Glu Met Glu Lys Leu Asn His Gln Gly Glu Leu Met Leu Lys
    4210                4215                4220                
Lys Ala Thr Asp Glu Thr Asp Arg Asp Ile Ile Arg Glu Pro Leu Thr
4225                4230                4235                4240
Glu Leu Lys His Leu Trp Glu Asn Leu Gly Glu Lys Ile Ala His Arg
                4245                4250                4255    
Gln His Lys Leu Glu Gly Ala Leu Leu Ala Leu Gly Gln Phe Gln His
            4260                4265                4270        
Ala Leu Glu Glu Leu Met Ser Trp Leu Thr His Thr Glu Glu Leu Leu
        4275                4280                4285            
Asp Ala Gln Arg Pro Ile Ser Gly Asp Pro Lys Val Ile Glu Val Glu
    4290                4295                4300                
Leu Ala Lys His His Val Leu Lys Asn Asp Val Leu Ala His Gln Ala
4305                4310                4315                4320
Thr Val Glu Thr Val Asn Lys Ala Gly Asn Glu Leu Leu Glu Ser Ser
                4325                4330                4335    
Ala Gly Asp Asp Ala Ser Ser Leu Arg Ser Arg Leu Glu Ala Met Asn
            4340                4345                4350        
Gln Cys Trp Glu Ser Val Leu Gln Lys Thr Glu Glu Arg Glu Gln Gln
        4355                4360                4365            
Leu Gln Ser Thr Leu Gln Gln Ala Gln Gly Phe His Ser Glu Ile Glu
    4370                4375                4380                
Asp Phe Leu Leu Glu Leu Thr Arg Met Glu Ser Gln Leu Ser Ala Ser
4385                4390                4395                4400
Lys Pro Thr Gly Gly Leu Pro Glu Thr Ala Arg Glu Gln Leu Asp Thr
                4405                4410                4415    
His Met Glu Leu Tyr Ser Gln Leu Lys Ala Lys Glu Glu Thr Tyr Asn
            4420                4425                4430        
Gln Leu Leu Asp Lys Gly Arg Leu Met Leu Leu Ser Arg Asp Asp Ser
        4435                4440                4445            
Gly Ser Gly Ser Lys Thr Glu Gln Ser Val Ala Leu Leu Glu Gln Lys
    4450                4455                4460                
Trp His Val Val Ser Ser Lys Met Glu Glu Arg Lys Ser Lys Leu Glu
4465                4470                4475                4480
Glu Ala Leu Asn Leu Ala Thr Glu Phe Gln Asn Ser Leu Gln Glu Phe
                4485                4490                4495    
Ile Asn Trp Leu Thr Leu Ala Glu Gln Ser Leu Asn Ile Ala Ser Pro
            4500                4505                4510        
Pro Ser Leu Ile Leu Asn Thr Val Leu Ser Gln Ile Glu Glu His Lys
        4515                4520                4525            
Val Phe Ala Asn Glu Val Asn Ala His Arg Asp Gln Ile Ile Glu Leu
    4530                4535                4540                
Asp Gln Thr Gly Asn Gln Leu Lys Phe Leu Ser Gln Lys Gln Asp Val
4545                4550                4555                4560
Val Leu Ile Lys Asn Leu Leu Val Ser Val Gln Ser Arg Trp Glu Lys
                4565                4570                4575    
Val Val Gln Arg Ser Ile Glu Arg Gly Arg Ser Leu Asp Asp Ala Arg
            4580                4585                4590        
Lys Arg Ala Lys Gln Phe His Glu Ala Trp Lys Lys Leu Ile Asp Trp
        4595                4600                4605            
Leu Glu Asp Ala Glu Ser His Leu Asp Ser Glu Leu Glu Ile Ser Asn
    4610                4615                4620                
Asp Pro Asp Lys Ile Lys Leu Gln Leu Ser Lys His Lys Glu Phe Gln
4625                4630                4635                4640
Lys Thr Leu Gly Gly Lys Gln Pro Val Tyr Asp Thr Thr Ile Arg Thr
                4645                4650                4655    
Gly Arg Ala Leu Lys Glu Lys Thr Leu Leu Pro Glu Asp Ser Gln Lys
            4660                4665                4670        
Leu Asp Asn Phe Leu Gly Glu Val Arg Asp Lys Trp Asp Thr Val Cys
        4675                4680                4685            
Gly Lys Ser Val Glu Arg Gln His Lys Leu Glu Glu Ala Leu Leu Phe
    4690                4695                4700                
Ser Gly Gln Phe Met Asp Ala Leu Gln Ala Leu Val Asp Trp Leu Tyr
4705                4710                4715                4720
Lys Val Glu Pro Gln Leu Ala Glu Asp Gln Pro Val His Gly Asp Leu
                4725                4730                4735    
Asp Leu Val Met Asn Leu Met Asp Ala His Lys Val Phe Gln Lys Glu
            4740                4745                4750        
Leu Gly Lys Arg Thr Gly Thr Val Gln Val Leu Lys Arg Ser Gly Arg
        4755                4760                4765            
Glu Leu Ile Glu Asn Ser Arg Asp Asp Thr Thr Trp Val Lys Gly Gln
    4770                4775                4780                
Leu Gln Glu Leu Ser Thr Arg Trp Asp Thr Val Cys Lys Leu Ser Val
4785                4790                4795                4800
Ser Lys Gln Ser Arg Leu Glu Gln Ala Leu Lys Gln Ala Glu Val Phe
                4805                4810                4815    
Arg Asp Thr Val His Met Leu Leu Glu Trp Leu Ser Glu Ala Glu Gln
            4820                4825                4830        
Thr Leu Arg Phe Arg Gly Ala Leu Pro Asp Asp Thr Glu Ala Leu Gln
        4835                4840                4845            
Ser Leu Ile Asp Thr His Lys Glu Phe Met Lys Lys Val Glu Glu Lys
    4850                4855                4860                
Arg Val Asp Val Asn Ser Ala Val Ala Met Gly Glu Val Ile Leu Ala
4865                4870                4875                4880
Val Cys His Pro Asp Cys Ile Thr Thr Ile Lys His Trp Ile Thr Ile
                4885                4890                4895    
Ile Arg Ala Arg Phe Glu Glu Val Leu Thr Trp Ala Lys Gln His Gln
            4900                4905                4910        
Gln Arg Leu Glu Thr Ala Leu Ser Glu Leu Val Ala Asn Ala Glu Leu
        4915                4920                4925            
Leu Glu Glu Leu Leu Ala Trp Ile Gln Trp Ala Glu Thr Thr Leu Ile
    4930                4935                4940                
Gln Arg Asp Gln Glu Pro Ile Pro Gln Asn Ile Asp Arg Val Lys Ala
4945                4950                4955                4960
Leu Ile Ala Glu His Gln Thr Phe Met Glu Glu Met Thr Arg Lys Gln
                4965                4970                4975    
Pro Asp Val Asp Arg Val Thr Lys Thr Tyr Lys Arg Lys Asn Ile Glu
            4980                4985                4990        
Pro Thr His Ala Pro Phe Ile Glu Lys Ser Arg Ser Gly Gly Arg Lys
        4995                5000                5005            
Ser Leu Ser Gln Pro Thr Pro Pro Pro Met Pro Ile Leu Ser Gln Ser
    5010                5015                5020                
Glu Ala Lys Asn Pro Arg Ile Asn Gln Leu Ser Ala Arg Trp Gln Gln
5025                5030                5035                5040
Val Trp Leu Leu Ala Leu Glu Arg Gln Arg Lys Leu Asn Asp Ala Leu
                5045                5050                5055    
Asp Arg Leu Glu Glu Leu Lys Glu Phe Ala Asn Phe Asp Phe Asp Val
            5060                5065                5070        
Trp Arg Lys Lys Tyr Met Arg Trp Met Asn His Lys Lys Ser Arg Val
        5075                5080                5085            
Met Asp Phe Phe Arg Arg Ile Asp Lys Asp Gln Asp Gly Lys Ile Thr
    5090                5095                5100                
Arg Gln Glu Phe Ile Asp Gly Ile Leu Ala Ser Lys Phe Pro Thr Thr
5105                5110                5115                5120
Lys Leu Glu Met Thr Ala Val Ala Asp Ile Phe Asp Arg Asp Gly Asp
                5125                5130                5135    
Gly Tyr Ile Asp Tyr Tyr Glu Phe Val Ala Ala Leu His Pro Asn Lys
            5140                5145                5150        
Asp Ala Tyr Arg Pro Thr Thr Asp Ala Asp Lys Ile Glu Asp Glu Val
        5155                5160                5165            
Thr Arg Gln Val Ala Gln Cys Lys Cys Ala Lys Arg Phe Gln Val Glu
    5170                5175                5180                
Gln Ile Gly Glu Asn Lys Tyr Arg Phe Gly Asp Ser Gln Gln Leu Arg
5185                5190                5195                5200
Leu Val Arg Ile Leu Arg Ser Thr Val Met Val Arg Val Gly Gly Gly
                5205                5210                5215    
Trp Met Ala Leu Asp Glu Phe Leu Val Lys Asn Asp Pro Cys Arg Ala
            5220                5225                5230        
Arg Gly Arg Thr Asn Ile Glu Leu Arg Glu Lys Phe Ile Leu Pro Glu
        5235                5240                5245            
Gly Ala Ser Gln Gly Met Thr Pro Phe Arg Ser Arg Gly Arg Arg Ser
    5250                5255                5260                
Lys Pro Ser Ser Arg Ala Ala Ser Pro Thr Arg Ser Ser Ser Ser Ala
5265                5270                5275                5280
Ser Gln Ser Asn His Ser Cys Thr Ser Met Pro Ser Ser Pro Ala Thr
                5285                5290                5295    
Pro Ala Ser Gly Thr Lys Val Ile Pro Ser Ser Gly Ser Lys Leu Lys
            5300                5305                5310        
Arg Pro Thr Pro Thr Phe His Ser Ser Arg Thr Ser Leu Ala Gly Asp
        5315                5320                5325            
Thr Ser Asn Ser Ser Ser Pro Ala Ser Thr Gly Ala Lys Thr Asn Arg
    5330                5335                5340                
Ala Asp Pro Lys Lys Ser Ala Ser Arg Pro Gly Ser Arg Ala Gly Ser
5345                5350                5355                5360
Arg Ala Gly Ser Arg Ala Ser Ser Arg Arg Gly Ser Asp Ala Ser Asp
                5365                5370                5375    
Phe Asp Leu Leu Glu Thr Gln Ser Ala Cys Ser Asp Thr Ser Glu Ser
            5380                5385                5390        
Ser Ala Ala Gly Gly Gln Gly Asn Ser Arg Arg Gly Leu Asn Lys Pro
        5395                5400                5405            
Ser Lys Ile Pro Thr Met Ser Lys Lys Thr Thr Thr Ala Ser Pro Arg
    5410                5415                5420                
Thr Pro Gly Pro Lys Arg
5425                5430


<210> 6059
<211> 1036
<212> PRT
<213> Homo sapiens

<400> 6059
Met Ala Leu Arg Gly Ala Ala Gly Ala Thr Asp Thr Pro Val Ser Ser
 1               5                  10                  15      
Ala Gly Gly Ala Pro Gly Gly Ser Ala Ser Ser Ser Ser Thr Ser Ser
            20                  25                  30          
Gly Gly Ser Ala Ser Ala Gly Ala Gly Leu Trp Ala Ala Leu Tyr Asp
        35                  40                  45              
Tyr Glu Ala Arg Gly Glu Asp Glu Leu Ser Leu Arg Arg Gly Gln Leu
    50                  55                  60                  
Val Glu Val Leu Ser Gln Asp Ala Ala Val Ser Gly Asp Glu Gly Trp
65                  70                  75                  80  
Trp Ala Gly Gln Val Gln Arg Arg Leu Gly Ile Phe Pro Ala Asn Tyr
                85                  90                  95      
Val Ala Pro Cys Arg Pro Ala Ala Ser Pro Ala Pro Pro Pro Ser Arg
            100                 105                 110         
Pro Ser Ser Pro Val His Val Ala Phe Glu Arg Leu Glu Leu Lys Glu
        115                 120                 125             
Leu Ile Gly Ala Gly Gly Phe Gly Gln Val Tyr Arg Ala Thr Trp Gln
    130                 135                 140                 
Gly Gln Glu Val Ala Val Lys Ala Ala Arg Gln Asp Pro Glu Gln Asp
145                 150                 155                 160 
Ala Ala Ala Ala Ala Glu Ser Val Arg Arg Glu Ala Arg Leu Phe Ala
                165                 170                 175     
Met Leu Arg His Pro Asn Ile Ile Glu Leu Arg Gly Val Cys Leu Gln
            180                 185                 190         
Gln Pro His Leu Cys Leu Val Leu Glu Phe Ala Arg Gly Gly Ala Leu
        195                 200                 205             
Asn Arg Ala Leu Ala Ala Ala Asn Ala Ala Pro Asp Pro Arg Ala Pro
    210                 215                 220                 
Gly Pro Arg Arg Ala Arg Arg Ile Pro Pro His Val Leu Val Asn Trp
225                 230                 235                 240 
Ala Val Gln Ile Ala Arg Gly Met Leu Tyr Leu His Glu Glu Ala Phe
                245                 250                 255     
Val Pro Ile Leu His Arg Asp Leu Lys Ser Ser Asn Ile Leu Leu Leu
            260                 265                 270         
Glu Glu Ile Glu His Asp Asp Ile Cys Asn Lys Thr Leu Lys Ile Thr
        275                 280                 285             
Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr Thr Lys Met Ser Thr
    290                 295                 300                 
Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Lys Ser Ser Leu
305                 310                 315                 320 
Phe Ser Lys Gly Ser Asp Ile Trp Ser Cys Gly Val Leu Leu Trp Glu
                325                 330                 335     
Leu Leu Thr Gly Glu Val Pro Tyr Arg Gly Ile Asp Gly Leu Ala Val
            340                 345                 350         
Ala Tyr Gly Val Ala Val Asn Lys Leu Thr Leu Pro Ile Pro Ser Thr
        355                 360                 365             
Cys Pro Glu Pro Phe Ala Lys Leu Met Lys Glu Cys Trp Gln Gln Asp
    370                 375                 380                 
Pro His Ile Arg Pro Ser Phe Ala Leu Ile Leu Glu Gln Leu Thr Ala
385                 390                 395                 400 
Ile Glu Gly Ala Val Met Thr Glu Met Pro Gln Glu Ser Phe His Ser
                405                 410                 415     
Met Gln Asp Asp Trp Lys Leu Glu Ile Gln Gln Met Phe Asp Glu Leu
            420                 425                 430         
Arg Thr Lys Glu Lys Glu Leu Arg Ser Arg Glu Glu Glu Leu Thr Arg
        435                 440                 445             
Ala Ala Leu Gln Gln Lys Ser Gln Glu Glu Leu Leu Lys Arg Arg Glu
    450                 455                 460                 
Gln Gln Leu Ala Glu Arg Glu Ile Asp Val Leu Glu Arg Glu Leu Asn
465                 470                 475                 480 
Ile Leu Ile Phe Gln Leu Asn Gln Glu Lys Pro Lys Val Lys Lys Arg
                485                 490                 495     
Lys Gly Lys Phe Lys Arg Ser Arg Leu Lys Leu Lys Asp Gly His Arg
            500                 505                 510         
Ile Ser Leu Pro Ser Asp Phe Gln His Lys Ile Thr Val Gln Ala Ser
        515                 520                 525             
Pro Asn Leu Asp Lys Arg Arg Ser Leu Asn Ser Ser Ser Ser Ser Pro
    530                 535                 540                 
Pro Ser Ser Pro Thr Met Met Pro Arg Leu Arg Ala Ile Gln Leu Thr
545                 550                 555                 560 
Ser Asp Glu Ser Asn Lys Thr Trp Gly Arg Asn Thr Val Phe Arg Gln
                565                 570                 575     
Glu Glu Phe Glu Asp Val Lys Arg Asn Phe Lys Lys Lys Gly Cys Thr
            580                 585                 590         
Trp Gly Pro Asn Ser Ile Gln Met Lys Asp Arg Thr Asp Cys Lys Glu
        595                 600                 605             
Arg Ile Arg Pro Leu Ser Asp Gly Asn Ser Pro Trp Ser Thr Ile Leu
    610                 615                 620                 
Ile Lys Asn Gln Lys Thr Met Pro Leu Ala Ser Leu Phe Val Asp Gln
625                 630                 635                 640 
Pro Gly Ser Cys Glu Glu Pro Lys Leu Ser Pro Asp Gly Leu Glu His
                645                 650                 655     
Arg Lys Pro Lys Gln Ile Lys Leu Pro Ser Gln Ala Tyr Ile Asp Leu
            660                 665                 670         
Pro Leu Gly Lys Asp Ala Gln Arg Glu Asn Pro Ala Glu Ala Gly Ser
        675                 680                 685             
Trp Glu Glu Ala Ala Ser Ala Asn Ala Ala Thr Val Thr Ile Glu Met
    690                 695                 700                 
Ala Pro Thr Asn Ser Leu Ser Arg Ser Pro Gln Arg Lys Lys Thr Glu
705                 710                 715                 720 
Ser Ala Leu Tyr Gly Cys Thr Val Leu Leu Ala Ser Val Ala Leu Gly
                725                 730                 735     
Leu Asp Leu Arg Glu Leu His Lys Ala Gln Ala Ala Glu Glu Pro Leu
            740                 745                 750         
Pro Lys Glu Glu Lys Lys Lys Arg Glu Gly Ile Phe Gln Arg Ala Ser
        755                 760                 765             
Lys Ser Arg Arg Ser Ala Ser Pro Pro Thr Ser Leu Ser Ser Thr Cys
    770                 775                 780                 
Gly Glu Ala Ser Ser Pro Pro Ser Leu Pro Leu Ser Ser Ala Leu Gly
785                 790                 795                 800 
Ile Leu Ser Thr Pro Ser Phe Ser Thr Lys Cys Leu Leu Gln Met Asp
                805                 810                 815     
Ser Glu Asp Pro Leu Val Asp Ser Ala Pro Val Thr Cys Asp Ser Glu
            820                 825                 830         
Met Leu Thr Pro Asp Phe Cys Pro Thr Ala Pro Gly Ser Gly Arg Glu
        835                 840                 845             
Pro Ala Leu Met Pro Arg Leu Asp Thr Asp Cys Ser Val Ser Arg Asn
    850                 855                 860                 
Leu Pro Ser Ser Phe Leu Gln Arg Thr Cys Gly Asn Val Pro Tyr Cys
865                 870                 875                 880 
Ala Ser Ser Lys His Arg Pro Ser His His Arg Arg Thr Met Ser Asp
                885                 890                 895     
Gly Asn Pro Thr Pro Thr Gly Ala Thr Ile Ile Ser Ala Thr Gly Ala
            900                 905                 910         
Ser Ala Leu Pro Leu Cys Pro Ser Pro Ala Pro His Ser His Leu Pro
        915                 920                 925             
Arg Glu Val Ser Pro Lys Lys His Ser Thr Val His Ile Val Pro Gln
    930                 935                 940                 
Arg Arg Pro Ala Ser Leu Arg Ser Arg Ser Asp Leu Pro Gln Ala Tyr
945                 950                 955                 960 
Pro Gln Thr Ala Val Ser Gln Leu Ala Gln Thr Ala Cys Val Val Gly
                965                 970                 975     
Arg Pro Gly Pro His Pro Thr Gln Phe Leu Ala Ala Lys Glu Arg Thr
            980                 985                 990         
Lys Ser His Val Pro Ser Leu Leu Asp Val Asp Val Glu Gly Gln Ser
        995                 1000                1005            
Arg Asp Tyr Thr Val Pro Leu Gly Arg Met Arg Ser Lys Thr Ser Arg
    1010                1015                1020                
Pro Ser Ile Tyr Glu Leu Glu Lys Glu Phe Leu Ser
1025                1030                1035    


<210> 6060
<211> 412
<212> PRT
<213> Homo sapiens

<400> 6060
Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro
 1               5                  10                  15      
Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala
            20                  25                  30          
Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys
        35                  40                  45              
Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu
    50                  55                  60                  
Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly
65                  70                  75                  80  
Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu
                85                  90                  95      
Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg
            100                 105                 110         
Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr
        115                 120                 125             
Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser
    130                 135                 140                 
Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser
145                 150                 155                 160 
Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro
                165                 170                 175     
Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu
            180                 185                 190         
Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys
        195                 200                 205             
Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly
    210                 215                 220                 
Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala
225                 230                 235                 240 
Pro Gly Val Glu Pro Gly Asp Ile Val Leu Leu Leu Gln Glu Lys Glu
                245                 250                 255     
His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys
            260                 265                 270         
Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His
        275                 280                 285             
Leu Asp Gly Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile
    290                 295                 300                 
Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr
305                 310                 315                 320 
Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln
                325                 330                 335     
Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu
            340                 345                 350         
Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Ile Ile Gly Glu Thr
        355                 360                 365             
Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly
    370                 375                 380                 
Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser
385                 390                 395                 400 
Ser His His Gly Pro Gly Val Gln Cys Ala His Gln
                405                 410         


<210> 6061
<211> 371
<212> PRT
<213> Homo sapiens

<400> 6061
Met Ser Val Val Lys Ser Ile Glu Leu Val Leu Pro Glu Asp Arg Ile
 1               5                  10                  15      
Tyr Leu Ala Gly Ser Ser Ile Lys Gly Gln Val Ile Leu Thr Leu Asn
            20                  25                  30          
Ser Thr Leu Val Asp Pro Ile Val Lys Val Glu Leu Val Gly Arg Gly
        35                  40                  45              
Tyr Val Glu Trp Ser Glu Glu Ala Gly Ala Ser Cys Asp Tyr Ser Arg
    50                  55                  60                  
Asn Val Ile Cys Asn Asn Lys Ala Asp Tyr Val His Lys Thr Lys Thr
65                  70                  75                  80  
Phe Pro Val Glu Asp Asn Trp Leu Ser Ala Gly Ser His Thr Phe Asp
                85                  90                  95      
Phe His Phe Asn Leu Pro Pro Arg Leu Pro Ser Thr Phe Thr Ser Lys
            100                 105                 110         
Phe Gly His Val Phe Tyr Phe Val Gln Ala Ser Cys Met Gly Arg Glu
        115                 120                 125             
His Ile Leu Ala Lys Lys Arg Met Tyr Leu Leu Val Gln Gly Thr Ser
    130                 135                 140                 
Thr Phe His Lys Glu Thr Pro Phe Gln Val Pro Met Gly Glu Arg Trp
145                 150                 155                 160 
Arg Trp Glu Gln Ser Pro Ser Ser Lys Glu Glu Glu Gly Arg Arg Gly
                165                 170                 175     
Gly Gly Ala Pro Ala Ala Pro Glu Lys Ala Glu Glu Lys Pro Glu Ala
            180                 185                 190         
Glu Lys Trp Glu Asn Pro Leu Phe Val Glu Ala Glu Glu Lys Val Ser
        195                 200                 205             
Tyr Asn Cys Cys Arg Gln Gly Thr Val Cys Leu Gln Ile Gln Met Glu
    210                 215                 220                 
Arg Asn Thr Phe Thr Pro Gly Glu Lys Val Val Phe Thr Thr Glu Ile
225                 230                 235                 240 
Asn Asn Gln Thr Ser Lys Cys Ile Lys Thr Val Val Phe Ala Leu Tyr
                245                 250                 255     
Ala His Ile Gln Tyr Glu Gly Phe Thr Pro Ser Ala Glu Arg Arg Ser
            260                 265                 270         
Arg Leu Asp Ser Ser Glu Leu Leu Arg Gln Glu Ala Asn Thr Pro Val
        275                 280                 285             
Thr Arg Phe Asn Thr Thr Lys Val Val Ser Thr Phe Asn Leu Pro Leu
    290                 295                 300                 
Leu Leu Ser Val Ser Ser Ser Thr Gln Asp Gly Glu Ile Met His Thr
305                 310                 315                 320 
Arg Tyr Glu Leu Val Thr Thr Val His Leu Pro Trp Ser Leu Thr Ser
                325                 330                 335     
Leu Lys Ala Lys Val Pro Ile Ile Ile Thr Ser Ala Ser Val Asp Ser
            340                 345                 350         
Ala Ile Cys Gln Leu Ser Glu Asp Gly Val Leu Pro Val Asn Pro Asp
        355                 360                 365             
His Gln Asn
    370     


<210> 6062
<211> 725
<212> PRT
<213> Homo sapiens

<400> 6062
Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly
 1               5                  10                  15      
Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu
            20                  25                  30          
Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys
        35                  40                  45              
Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala
    50                  55                  60                  
Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Lys Glu Ser Gln Lys
65                  70                  75                  80  
Asn Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu
                85                  90                  95      
Gln Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu
            100                 105                 110         
Leu Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr
        115                 120                 125             
Ser Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu
    130                 135                 140                 
Thr Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn
145                 150                 155                 160 
Gln Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn
                165                 170                 175     
Lys Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met
            180                 185                 190         
Glu Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly
        195                 200                 205             
Lys Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys
    210                 215                 220                 
Ile Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu
225                 230                 235                 240 
Ile Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala
                245                 250                 255     
Gln Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu
            260                 265                 270         
Lys Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu
        275                 280                 285             
Asp Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His
    290                 295                 300                 
Val Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln
305                 310                 315                 320 
Asn Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu
                325                 330                 335     
Gln Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu
            340                 345                 350         
Leu Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met
        355                 360                 365             
Val Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp
    370                 375                 380                 
Glu Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val
385                 390                 395                 400 
Lys Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu
                405                 410                 415     
Leu Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser
            420                 425                 430         
Ala Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser
        435                 440                 445             
Met Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys
    450                 455                 460                 
Ala Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser
465                 470                 475                 480 
Leu Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln
                485                 490                 495     
His Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met
            500                 505                 510         
Leu Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys
        515                 520                 525             
Glu Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln
    530                 535                 540                 
Leu Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu
545                 550                 555                 560 
Gly Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu
                565                 570                 575     
Ile Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys
            580                 585                 590         
Pro Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu
        595                 600                 605             
Leu Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp
    610                 615                 620                 
Ser Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys
625                 630                 635                 640 
His Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val
                645                 650                 655     
Ser Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys
            660                 665                 670         
Leu Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro
        675                 680                 685             
Ser Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr
    690                 695                 700                 
Pro Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys
705                 710                 715                 720 
Gln Glu Ser Trp Lys
                725 


<210> 6063
<211> 724
<212> PRT
<213> Homo sapiens

<400> 6063
Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly
 1               5                  10                  15      
Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu
            20                  25                  30          
Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys
        35                  40                  45              
Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala
    50                  55                  60                  
Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Glu Ser Gln Lys Asn
65                  70                  75                  80  
Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu Gln
                85                  90                  95      
Glu Arg Gly Ala Gln Asp Ser Arg Ile Gln Asp Leu Glu Thr Glu Leu
            100                 105                 110         
Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr Ser
        115                 120                 125             
Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu Thr
    130                 135                 140                 
Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn Gln
145                 150                 155                 160 
Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn Lys
                165                 170                 175     
Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met Glu
            180                 185                 190         
Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly Lys
        195                 200                 205             
Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys Ile
    210                 215                 220                 
Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu Ile
225                 230                 235                 240 
Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala Gln
                245                 250                 255     
Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu Lys
            260                 265                 270         
Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu Asp
        275                 280                 285             
Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His Val
    290                 295                 300                 
Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln Asn
305                 310                 315                 320 
Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu Gln
                325                 330                 335     
Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu Leu
            340                 345                 350         
Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met Val
        355                 360                 365             
Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp Glu
    370                 375                 380                 
Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val Lys
385                 390                 395                 400 
Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu Leu
                405                 410                 415     
Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser Ala
            420                 425                 430         
Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser Met
        435                 440                 445             
Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys Ala
    450                 455                 460                 
Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser Leu
465                 470                 475                 480 
Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln His
                485                 490                 495     
Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met Leu
            500                 505                 510         
Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys Glu
        515                 520                 525             
Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln Leu
    530                 535                 540                 
Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu Gly
545                 550                 555                 560 
Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu Ile
                565                 570                 575     
Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys Pro
            580                 585                 590         
Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu Leu
        595                 600                 605             
Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp Ser
    610                 615                 620                 
Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys His
625                 630                 635                 640 
Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val Ser
                645                 650                 655     
Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys Leu
            660                 665                 670         
Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro Ser
        675                 680                 685             
Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr Pro
    690                 695                 700                 
Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys Gln
705                 710                 715                 720 
Glu Ser Trp Lys
                


<210> 6064
<211> 709
<212> PRT
<213> Homo sapiens

<400> 6064
Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly
 1               5                  10                  15      
Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu
            20                  25                  30          
Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys
        35                  40                  45              
Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala
    50                  55                  60                  
Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Ile Arg Val Leu Leu
65                  70                  75                  80  
Gln Glu Arg Gly Ala Gln Asp Ser Arg Ile Gln Asp Leu Glu Thr Glu
                85                  90                  95      
Leu Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr
            100                 105                 110         
Ser Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu
        115                 120                 125             
Thr Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn
    130                 135                 140                 
Gln Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn
145                 150                 155                 160 
Lys Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met
                165                 170                 175     
Glu Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly
            180                 185                 190         
Lys Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys
        195                 200                 205             
Ile Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu
    210                 215                 220                 
Ile Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala
225                 230                 235                 240 
Gln Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu
                245                 250                 255     
Lys Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu
            260                 265                 270         
Asp Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His
        275                 280                 285             
Val Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln
    290                 295                 300                 
Asn Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu
305                 310                 315                 320 
Gln Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu
                325                 330                 335     
Leu Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met
            340                 345                 350         
Val Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp
        355                 360                 365             
Glu Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val
    370                 375                 380                 
Lys Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu
385                 390                 395                 400 
Leu Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser
                405                 410                 415     
Ala Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser
            420                 425                 430         
Met Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys
        435                 440                 445             
Ala Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser
    450                 455                 460                 
Leu Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln
465                 470                 475                 480 
His Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met
                485                 490                 495     
Leu Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys
            500                 505                 510         
Glu Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln
        515                 520                 525             
Leu Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu
    530                 535                 540                 
Gly Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu
545                 550                 555                 560 
Ile Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys
                565                 570                 575     
Pro Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu
            580                 585                 590         
Leu Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp
        595                 600                 605             
Ser Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys
    610                 615                 620                 
His Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val
625                 630                 635                 640 
Ser Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys
                645                 650                 655     
Leu Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro
            660                 665                 670         
Ser Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr
        675                 680                 685             
Pro Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys
    690                 695                 700                 
Gln Glu Ser Trp Lys
705                 


<210> 6065
<211> 496
<212> PRT
<213> Homo sapiens

<400> 6065
Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser
 1               5                  10                  15      
Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro
            20                  25                  30          
Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val
        35                  40                  45              
Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg
    50                  55                  60                  
Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln
65                  70                  75                  80  
Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu
                85                  90                  95      
Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala
            100                 105                 110         
Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser Gly
        115                 120                 125             
Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu Phe
    130                 135                 140                 
Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn Ala
145                 150                 155                 160 
Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro Ala
                165                 170                 175     
Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile Val
            180                 185                 190         
Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile Ser
        195                 200                 205             
Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu Tyr
    210                 215                 220                 
Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val Met
225                 230                 235                 240 
Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn Lys
                245                 250                 255     
Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu Gly
            260                 265                 270         
Phe Lys Val Pro Gln Arg Gln Pro Thr Lys Pro Ala Leu Lys Ser Glu
        275                 280                 285             
Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr Phe
    290                 295                 300                 
Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu Asp
305                 310                 315                 320 
Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly Ile
                325                 330                 335     
Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln Gly
            340                 345                 350         
His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys Ala
        355                 360                 365             
Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr Ser
    370                 375                 380                 
Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His Val
385                 390                 395                 400 
Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu Ser
                405                 410                 415     
Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn Asn
            420                 425                 430         
Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro Leu
        435                 440                 445             
Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met Ala
    450                 455                 460                 
Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser Thr
465                 470                 475                 480 
Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg Cys
                485                 490                 495     


<210> 6066
<211> 577
<212> PRT
<213> Homo sapiens

<400> 6066
Met Ser Gln Val Gln Val Gln Val Gln Asn Pro Ser Ala Ala Leu Ser
 1               5                  10                  15      
Gly Ser Gln Ile Leu Asn Lys Asn Gln Ser Leu Leu Ser Gln Pro Leu
            20                  25                  30          
Met Ser Ile Pro Ser Thr Thr Ser Ser Leu Pro Ser Glu Asn Ala Gly
        35                  40                  45              
Arg Pro Ile Gln Asn Ser Ala Leu Pro Ser Ala Ser Ile Thr Ser Thr
    50                  55                  60                  
Ser Ala Ala Ala Glu Ser Ile Thr Pro Thr Val Glu Leu Asn Ala Leu
65                  70                  75                  80  
Cys Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr
                85                  90                  95      
Ser Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr
            100                 105                 110         
Pro Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln
        115                 120                 125             
Val Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr
    130                 135                 140                 
Arg Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu
145                 150                 155                 160 
Gln Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser
                165                 170                 175     
Glu Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile
            180                 185                 190         
Ala Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser
        195                 200                 205             
Gly Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu
    210                 215                 220                 
Phe Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn
225                 230                 235                 240 
Ala Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro
                245                 250                 255     
Ala Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile
            260                 265                 270         
Val Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile
        275                 280                 285             
Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu
    290                 295                 300                 
Tyr Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val
305                 310                 315                 320 
Met Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn
                325                 330                 335     
Lys Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu
            340                 345                 350         
Gly Phe Lys Val Pro Gln Arg Gln Pro Thr Lys Pro Ala Leu Lys Ser
        355                 360                 365             
Glu Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr
    370                 375                 380                 
Phe Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu
385                 390                 395                 400 
Asp Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly
                405                 410                 415     
Ile Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln
            420                 425                 430         
Gly His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys
        435                 440                 445             
Ala Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr
    450                 455                 460                 
Ser Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His
465                 470                 475                 480 
Val Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu
                485                 490                 495     
Ser Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn
            500                 505                 510         
Asn Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro
        515                 520                 525             
Leu Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met
    530                 535                 540                 
Ala Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser
545                 550                 555                 560 
Thr Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg
                565                 570                 575     
Cys
    


<210> 6067
<211> 594
<212> PRT
<213> Homo sapiens

<400> 6067
Arg His Phe Leu Pro Gly Cys Gly Arg Leu Ser Gly Ser Ser Ala Phe
 1               5                  10                  15      
Ala Pro Ala Ala Ala Ala Ser Leu Ser Ala Pro Ala Ser Phe Asp Arg
            20                  25                  30          
Leu Pro Pro Pro Ala Arg Arg Arg Pro Pro Pro Pro Arg Pro Leu Arg
        35                  40                  45              
Leu Phe Pro Pro Phe Val Pro Ser Ser Ser Pro Phe Phe Pro Ser Ser
    50                  55                  60                  
Phe Pro Ser Ser Pro Pro Pro Pro Arg Thr Ala Gly Arg Gly Thr Ser
65                  70                  75                  80  
Ser Glu Gln Gln Pro Glu Ser Ile Thr Pro Thr Val Glu Leu Asn Ala
                85                  90                  95      
Leu Cys Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro
            100                 105                 110         
Tyr Ser Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala
        115                 120                 125             
Tyr Pro Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr
    130                 135                 140                 
Gln Val Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys
145                 150                 155                 160 
Thr Arg Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile
                165                 170                 175     
Leu Gln Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu
            180                 185                 190         
Ser Glu Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu
        195                 200                 205             
Ile Ala Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu
    210                 215                 220                 
Ser Gly Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly
225                 230                 235                 240 
Glu Phe Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys
                245                 250                 255     
Asn Ala Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu
            260                 265                 270         
Pro Ala Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro
        275                 280                 285             
Ile Val Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro
    290                 295                 300                 
Ile Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro
305                 310                 315                 320 
Glu Tyr Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe
                325                 330                 335     
Val Met Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr
            340                 345                 350         
Asn Lys Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile
        355                 360                 365             
Leu Gly Phe Lys Val Pro Gln Ala Gln Pro Thr Lys Pro Ala Leu Lys
    370                 375                 380                 
Ser Glu Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val
385                 390                 395                 400 
Thr Phe Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys
                405                 410                 415     
Glu Asp Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala
            420                 425                 430         
Gly Ile Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser
        435                 440                 445             
Gln Gly His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala
    450                 455                 460                 
Lys Ala Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly
465                 470                 475                 480 
Thr Ser Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly
                485                 490                 495     
His Val Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr
            500                 505                 510         
Leu Ser Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys
        515                 520                 525             
Asn Asn Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro
    530                 535                 540                 
Pro Leu Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp
545                 550                 555                 560 
Met Ala Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln
                565                 570                 575     
Ser Thr Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly
            580                 585                 590         
Arg Cys
        


<210> 6068
<211> 760
<212> PRT
<213> Homo sapiens

<400> 6068
Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val
 1               5                  10                  15      
Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His
            20                  25                  30          
Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu
        35                  40                  45              
Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly
    50                  55                  60                  
Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn
65                  70                  75                  80  
Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys
                85                  90                  95      
Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val
            100                 105                 110         
Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala
        115                 120                 125             
Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn
    130                 135                 140                 
Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser
145                 150                 155                 160 
Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro
                165                 170                 175     
Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile
            180                 185                 190         
Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr
        195                 200                 205             
Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala
    210                 215                 220                 
Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly
225                 230                 235                 240 
Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly
                245                 250                 255     
Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro
            260                 265                 270         
Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser
        275                 280                 285             
Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val
    290                 295                 300                 
Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile
305                 310                 315                 320 
Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln
                325                 330                 335     
Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val
            340                 345                 350         
Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe
        355                 360                 365             
Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val
    370                 375                 380                 
Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile
385                 390                 395                 400 
Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu
                405                 410                 415     
Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr
            420                 425                 430         
Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys
        435                 440                 445             
Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu
    450                 455                 460                 
Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg
465                 470                 475                 480 
Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn
                485                 490                 495     
Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu
            500                 505                 510         
Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe
        515                 520                 525             
Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro
    530                 535                 540                 
Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr
545                 550                 555                 560 
Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly
                565                 570                 575     
Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu
            580                 585                 590         
Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile
        595                 600                 605             
Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser
    610                 615                 620                 
Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu
625                 630                 635                 640 
Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr
                645                 650                 655     
Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp
            660                 665                 670         
Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr
        675                 680                 685             
Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn
    690                 695                 700                 
Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala
705                 710                 715                 720 
Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu
                725                 730                 735     
Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu
            740                 745                 750         
Lys Gln Cys Phe Ser Leu Ser Asp
        755                 760 


<210> 6069
<211> 239
<212> PRT
<213> Homo sapiens

<400> 6069
Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu
 1               5                  10                  15      
Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe
            20                  25                  30          
Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile
        35                  40                  45              
Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu
    50                  55                  60                  
Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile
65                  70                  75                  80  
Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg
                85                  90                  95      
Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala
            100                 105                 110         
Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro
        115                 120                 125             
Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met
    130                 135                 140                 
Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr
145                 150                 155                 160 
Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile
                165                 170                 175     
His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile
            180                 185                 190         
Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr
        195                 200                 205             
Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr
    210                 215                 220                 
Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp
225                 230                 235                 


<210> 6070
<211> 760
<212> PRT
<213> Homo sapiens

<400> 6070
Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val
 1               5                  10                  15      
Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His
            20                  25                  30          
Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu
        35                  40                  45              
Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly
    50                  55                  60                  
Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn
65                  70                  75                  80  
Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys
                85                  90                  95      
Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val
            100                 105                 110         
Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala
        115                 120                 125             
Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn
    130                 135                 140                 
Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser
145                 150                 155                 160 
Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro
                165                 170                 175     
Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile
            180                 185                 190         
Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Pro Thr
        195                 200                 205             
Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala
    210                 215                 220                 
Glu Phe Asn Asp Lys Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly
225                 230                 235                 240 
Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly
                245                 250                 255     
Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro
            260                 265                 270         
Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser
        275                 280                 285             
Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val
    290                 295                 300                 
Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile
305                 310                 315                 320 
Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln
                325                 330                 335     
Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val
            340                 345                 350         
Ser Arg Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe
        355                 360                 365             
Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val
    370                 375                 380                 
Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile
385                 390                 395                 400 
Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu
                405                 410                 415     
Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr
            420                 425                 430         
Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys
        435                 440                 445             
Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu
    450                 455                 460                 
Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg
465                 470                 475                 480 
Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn
                485                 490                 495     
Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu
            500                 505                 510         
Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe
        515                 520                 525             
Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro
    530                 535                 540                 
Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr
545                 550                 555                 560 
Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly
                565                 570                 575     
Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu
            580                 585                 590         
Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile
        595                 600                 605             
Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser
    610                 615                 620                 
Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu
625                 630                 635                 640 
Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr
                645                 650                 655     
Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp
            660                 665                 670         
Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr
        675                 680                 685             
Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn
    690                 695                 700                 
Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala
705                 710                 715                 720 
Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu
                725                 730                 735     
Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu
            740                 745                 750         
Lys Gln Cys Phe Ser Leu Ser Asp
        755                 760 


<210> 6071
<211> 265
<212> PRT
<213> Homo sapiens

<400> 6071
Met Pro Met Arg His Arg Lys Lys Ala Ala Asp Lys Asn Leu Pro Cys
 1               5                  10                  15      
Arg Pro Leu Val Cys Ala Val Leu Asp Leu Met Val Glu Phe Ile Val
            20                  25                  30          
Thr His Met Met Lys Glu Phe Pro Met Asp Leu Tyr Ile Arg Cys Ile
        35                  40                  45              
Gln Val Val His Lys Leu Leu Cys Tyr Gln Lys Lys Cys Arg Val Arg
    50                  55                  60                  
Leu His Tyr Thr Trp Arg Glu Leu Trp Ser Ala Leu Ile Asn Leu Leu
65                  70                  75                  80  
Lys Phe Leu Met Ser Asn Glu Thr Val Leu Leu Ala Lys His Asn Ile
                85                  90                  95      
Phe Thr Leu Ala Leu Met Ile Val Asn Leu Phe Asn Met Phe Ile Thr
            100                 105                 110         
Tyr Gly Asp Thr Phe Leu Pro Thr Pro Ser Ser Tyr Asp Glu Leu Tyr
        115                 120                 125             
Tyr Glu Ile Ile Arg Met His Gln Ser Phe Asp Asn Leu Tyr Ser Met
    130                 135                 140                 
Val Leu Arg Leu Ser Thr Asn Ala Gly Gln Trp Lys Glu Ala Ala Ser
145                 150                 155                 160 
Lys Val Thr His Ala Leu Val Asn Ile Arg Ala Ile Ile Asn His Phe
                165                 170                 175     
Asn Pro Lys Ile Glu Ser Tyr Ala Ala Val Asn His Ile Ser Gln Leu
            180                 185                 190         
Ser Glu Glu Gln Val Leu Glu Val Val Arg Ala Asn Tyr Asp Thr Leu
        195                 200                 205             
Thr Leu Lys Leu Gln Asp Gly Leu Asp Gln Tyr Glu Arg Tyr Ser Glu
    210                 215                 220                 
Gln His Lys Glu Ala Ala Phe Phe Lys Glu Leu Val Arg Ser Ile Ser
225                 230                 235                 240 
Thr Asn Val Arg Arg Asn Leu Val Phe His Thr Leu Ser Gln Glu Val
                245                 250                 255     
Leu Leu Lys Glu Phe Ser Thr Ile Ser
            260                 265 


<210> 6072
<211> 758
<212> PRT
<213> Homo sapiens

<400> 6072
Met Ala Pro Ala Met Gln Pro Ala Glu Ile Gln Phe Ala Gln Arg Leu
 1               5                  10                  15      
Ala Ser Ser Glu Lys Gly Ile Arg Asp Arg Ala Val Lys Lys Leu Arg
            20                  25                  30          
Gln Tyr Ile Ser Val Lys Thr Gln Arg Glu Thr Gly Gly Phe Ser Gln
        35                  40                  45              
Glu Glu Leu Leu Lys Ile Trp Lys Gly Leu Phe Tyr Cys Met Trp Val
    50                  55                  60                  
Gln Asp Glu Pro Leu Leu Gln Glu Glu Leu Ala Asn Thr Ile Ala Gln
65                  70                  75                  80  
Leu Val His Ala Val Asn Asn Ser Ala Ala Gln His Leu Phe Ile Gln
                85                  90                  95      
Thr Phe Trp Gln Thr Met Asn Arg Glu Trp Lys Gly Ile Asp Arg Leu
            100                 105                 110         
Arg Leu Asp Lys Tyr Tyr Met Leu Ile Arg Leu Val Leu Arg Gln Ser
        115                 120                 125             
Phe Glu Val Leu Lys Arg Asn Gly Trp Glu Glu Ser Arg Ile Lys Val
    130                 135                 140                 
Phe Leu Asp Val Leu Met Lys Glu Val Leu Cys Pro Glu Ser Gln Ser
145                 150                 155                 160 
Pro Asn Gly Val Arg Phe His Phe Ile Asp Ile Tyr Leu Asp Glu Leu
                165                 170                 175     
Ser Lys Val Gly Gly Lys Glu Leu Leu Ala Asp Gln Asn Leu Lys Phe
            180                 185                 190         
Ile Asp Pro Phe Cys Lys Ile Ala Ala Lys Thr Lys Asp His Thr Leu
        195                 200                 205             
Val Gln Thr Ile Ala Arg Gly Val Phe Glu Ala Ile Val Asp Gln Ser
    210                 215                 220                 
Pro Phe Val Pro Glu Glu Thr Met Glu Glu Gln Lys Thr Lys Val Gly
225                 230                 235                 240 
Asp Gly Asp Leu Ser Ala Glu Glu Ile Pro Glu Asn Glu Val Ser Leu
                245                 250                 255     
Arg Arg Ala Val Ser Lys Lys Lys Thr Ala Leu Gly Lys Asn His Ser
            260                 265                 270         
Arg Lys Asp Gly Leu Ser Asp Glu Arg Gly Arg Asp Asp Cys Gly Thr
        275                 280                 285             
Phe Glu Asp Thr Gly Pro Leu Leu Gln Phe Asp Tyr Lys Ala Val Ala
    290                 295                 300                 
Asp Arg Leu Leu Glu Met Thr Ser Arg Lys Asn Thr Pro His Phe Asn
305                 310                 315                 320 
Arg Lys Arg Leu Ser Lys Leu Ile Lys Lys Phe Gln Asp Leu Ser Glu
                325                 330                 335     
Gly Ser Ser Ile Ser Gln Leu Ser Phe Ala Glu Asp Ile Ser Ala Asp
            340                 345                 350         
Glu Asp Asp Gln Ile Leu Ser Gln Gly Lys His Lys Lys Lys Gly Asn
        355                 360                 365             
Lys Leu Leu Glu Lys Thr Asn Leu Glu Lys Glu Lys Gly Ser Arg Val
    370                 375                 380                 
Phe Cys Val Glu Glu Glu Asp Ser Glu Ser Ser Leu Gln Lys Arg Arg
385                 390                 395                 400 
Arg Lys Lys Lys Lys Lys His His Leu Gln Pro Glu Asn Pro Gly Pro
                405                 410                 415     
Gly Gly Ala Ala Pro Ser Leu Glu Gln Asn Arg Gly Arg Glu Pro Glu
            420                 425                 430         
Ala Ser Gly Pro Lys Ala Leu Lys Ala Arg Val Ala Glu Pro Gly Ala
        435                 440                 445             
Glu Ala Thr Ser Ser Thr Gly Glu Glu Ser Gly Ser Glu His Pro Pro
    450                 455                 460                 
Ala Val Pro Met His Asn Lys Arg Lys Arg Pro Arg Lys Lys Ser Pro
465                 470                 475                 480 
Arg Ala His Arg Glu Met Leu Glu Ser Ala Val Leu Pro Pro Glu Asp
                485                 490                 495     
Met Ser Gln Ser Gly Pro Ser Gly Ser His Pro Gln Gly Pro Arg Gly
            500                 505                 510         
Ser Pro Thr Gly Gly Ala Gln Leu Leu Lys Arg Lys Arg Lys Leu Gly
        515                 520                 525             
Val Val Pro Val Asn Gly Ser Gly Leu Ser Thr Pro Ala Trp Pro Pro
    530                 535                 540                 
Leu Gln Gln Glu Gly Pro Pro Thr Gly Pro Ala Glu Gly Ala Asn Ser
545                 550                 555                 560 
His Thr Thr Leu Pro Gln Arg Arg Arg Leu Gln Lys Lys Lys Ala Gly
                565                 570                 575     
Pro Gly Ser Leu Glu Leu Cys Gly Leu Pro Ser Gln Lys Thr Ala Ser
            580                 585                 590         
Leu Lys Lys Arg Lys Lys Met Arg Val Met Ser Asn Leu Val Glu His
        595                 600                 605             
Asn Gly Val Leu Glu Ser Glu Ala Gly Gln Pro Gln Ala Leu Gly Ser
    610                 615                 620                 
Ser Gly Thr Cys Ser Ser Leu Lys Lys Gln Lys Leu Arg Ala Glu Ser
625                 630                 635                 640 
Asp Phe Val Lys Phe Asp Thr Pro Phe Leu Pro Lys Pro Leu Phe Phe
                645                 650                 655     
Arg Arg Ala Lys Ser Ser Thr Ala Thr His Pro Pro Gly Pro Ala Val
            660                 665                 670         
Gln Leu Asn Lys Thr Pro Ser Ser Ser Lys Lys Val Thr Phe Gly Leu
        675                 680                 685             
Asn Arg Asn Met Thr Ala Glu Phe Lys Lys Thr Asp Lys Ser Ile Leu
    690                 695                 700                 
Val Ser Pro Thr Gly Pro Ser Arg Val Ala Phe Asp Pro Glu Gln Lys
705                 710                 715                 720 
Pro Leu His Gly Val Leu Lys Thr Pro Thr Ser Ser Pro Ala Ser Ser
                725                 730                 735     
Pro Leu Val Ala Lys Lys Pro Leu Thr Thr Thr Pro Arg Arg Arg Pro
            740                 745                 750         
Arg Ala Met Asp Phe Phe
        755             


<210> 6073
<211> 740
<212> PRT
<213> Homo sapiens

<400> 6073
Met Ala Pro Ala Met Gln Pro Ala Glu Ile Gln Phe Ala Gln Arg Leu
 1               5                  10                  15      
Ala Ser Ser Glu Lys Gly Ile Arg Asp Arg Ala Val Lys Lys Leu Arg
            20                  25                  30          
Gln Tyr Ile Ser Val Lys Thr Gln Arg Glu Thr Gly Gly Phe Ser Gln
        35                  40                  45              
Glu Glu Leu Leu Gln Glu Glu Leu Ala Asn Thr Ile Ala Gln Leu Val
    50                  55                  60                  
His Ala Val Asn Asn Ser Ala Ala Gln His Leu Phe Ile Gln Thr Phe
65                  70                  75                  80  
Trp Gln Thr Met Asn Arg Glu Trp Lys Gly Ile Asp Arg Leu Arg Leu
                85                  90                  95      
Asp Lys Tyr Tyr Met Leu Ile Arg Leu Val Leu Arg Gln Ser Phe Glu
            100                 105                 110         
Val Leu Lys Arg Asn Gly Trp Glu Glu Ser Arg Ile Lys Val Phe Leu
        115                 120                 125             
Asp Val Leu Met Lys Glu Val Leu Cys Pro Glu Ser Gln Ser Pro Asn
    130                 135                 140                 
Gly Val Arg Phe His Phe Ile Asp Ile Tyr Leu Asp Glu Leu Ser Lys
145                 150                 155                 160 
Val Gly Gly Lys Glu Leu Leu Ala Asp Gln Asn Leu Lys Phe Ile Asp
                165                 170                 175     
Pro Phe Cys Lys Ile Ala Ala Lys Thr Lys Asp His Thr Leu Val Gln
            180                 185                 190         
Thr Ile Ala Arg Gly Val Phe Glu Ala Ile Val Asp Gln Ser Pro Phe
        195                 200                 205             
Val Pro Glu Glu Thr Met Glu Glu Gln Lys Thr Lys Val Gly Asp Gly
    210                 215                 220                 
Asp Leu Ser Ala Glu Glu Ile Pro Glu Asn Glu Val Ser Leu Arg Arg
225                 230                 235                 240 
Ala Val Ser Lys Lys Lys Thr Ala Leu Gly Lys Asn His Ser Arg Lys
                245                 250                 255     
Asp Gly Leu Ser Asp Glu Arg Gly Arg Asp Asp Cys Gly Thr Phe Glu
            260                 265                 270         
Asp Thr Gly Pro Leu Leu Gln Phe Asp Tyr Lys Ala Val Ala Asp Arg
        275                 280                 285             
Leu Leu Glu Met Thr Ser Arg Lys Asn Thr Pro His Phe Asn Arg Lys
    290                 295                 300                 
Arg Leu Ser Lys Leu Ile Lys Lys Phe Gln Asp Leu Ser Glu Gly Ser
305                 310                 315                 320 
Ser Ile Ser Gln Leu Ser Phe Ala Glu Asp Ile Ser Ala Asp Glu Asp
                325                 330                 335     
Asp Gln Ile Leu Ser Gln Gly Lys His Lys Lys Lys Gly Asn Lys Leu
            340                 345                 350         
Leu Glu Lys Thr Asn Leu Glu Lys Glu Lys Gly Ser Arg Val Phe Cys
        355                 360                 365             
Val Glu Glu Glu Asp Ser Glu Ser Ser Leu Gln Lys Arg Arg Arg Lys
    370                 375                 380                 
Lys Lys Lys Lys His His Leu Gln Pro Glu Asn Pro Gly Pro Gly Gly
385                 390                 395                 400 
Ala Ala Pro Ser Leu Glu Gln Asn Arg Gly Arg Glu Pro Glu Ala Ser
                405                 410                 415     
Gly Pro Lys Ala Leu Lys Ala Arg Val Ala Glu Pro Gly Ala Glu Ala
            420                 425                 430         
Thr Ser Ser Thr Gly Glu Glu Ser Gly Ser Glu His Pro Pro Ala Val
        435                 440                 445             
Pro Met His Asn Lys Arg Lys Arg Pro Arg Lys Lys Ser Pro Arg Ala
    450                 455                 460                 
His Arg Glu Met Leu Glu Ser Ala Val Leu Pro Pro Glu Asp Met Ser
465                 470                 475                 480 
Gln Ser Gly Pro Ser Gly Ser His Pro Gln Gly Pro Arg Gly Ser Pro
                485                 490                 495     
Thr Gly Gly Ala Gln Leu Leu Lys Arg Lys Arg Lys Leu Gly Val Val
            500                 505                 510         
Pro Val Asn Gly Ser Gly Leu Ser Thr Pro Ala Trp Pro Pro Leu Gln
        515                 520                 525             
Gln Glu Gly Pro Pro Thr Gly Pro Ala Glu Gly Ala Asn Ser His Thr
    530                 535                 540                 
Thr Leu Pro Gln Arg Arg Arg Leu Gln Lys Lys Lys Ala Gly Pro Gly
545                 550                 555                 560 
Ser Leu Glu Leu Cys Gly Leu Pro Ser Gln Lys Thr Ala Ser Leu Lys
                565                 570                 575     
Lys Arg Lys Lys Met Arg Val Met Ser Asn Leu Val Glu His Asn Gly
            580                 585                 590         
Val Leu Glu Ser Glu Ala Gly Gln Pro Gln Ala Leu Gly Ser Ser Gly
        595                 600                 605             
Thr Cys Ser Ser Leu Lys Lys Gln Lys Leu Arg Ala Glu Ser Asp Phe
    610                 615                 620                 
Val Lys Phe Asp Thr Pro Phe Leu Pro Lys Pro Leu Phe Phe Arg Arg
625                 630                 635                 640 
Ala Lys Ser Ser Thr Ala Thr His Pro Pro Gly Pro Ala Val Gln Leu
                645                 650                 655     
Asn Lys Thr Pro Ser Ser Ser Lys Lys Val Thr Phe Gly Leu Asn Arg
            660                 665                 670         
Asn Met Thr Ala Glu Phe Lys Lys Thr Asp Lys Ser Ile Leu Val Ser
        675                 680                 685             
Pro Thr Gly Pro Ser Arg Val Ala Phe Asp Pro Glu Gln Lys Pro Leu
    690                 695                 700                 
His Gly Val Leu Lys Thr Pro Thr Ser Ser Pro Ala Ser Ser Pro Leu
705                 710                 715                 720 
Val Ala Lys Lys Pro Leu Thr Thr Thr Pro Arg Arg Arg Pro Arg Ala
                725                 730                 735     
Met Asp Phe Phe
            740 


<210> 6074
<211> 902
<212> PRT
<213> Homo sapiens

<400> 6074
Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr
 1               5                  10                  15      
Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp
            20                  25                  30          
Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu
        35                  40                  45              
Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln
    50                  55                  60                  
Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu
65                  70                  75                  80  
Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu
                85                  90                  95      
Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln
            100                 105                 110         
Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln
        115                 120                 125             
Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn
    130                 135                 140                 
Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile
145                 150                 155                 160 
Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu
                165                 170                 175     
Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr
            180                 185                 190         
Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys
        195                 200                 205             
Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val
    210                 215                 220                 
Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly
225                 230                 235                 240 
Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val
                245                 250                 255     
Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln
            260                 265                 270         
Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly
        275                 280                 285             
Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp
    290                 295                 300                 
Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu
305                 310                 315                 320 
Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile
                325                 330                 335     
Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln
            340                 345                 350         
Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys
        355                 360                 365             
Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu
    370                 375                 380                 
Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln
385                 390                 395                 400 
Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu
                405                 410                 415     
Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys
            420                 425                 430         
His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys
        435                 440                 445             
Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser
    450                 455                 460                 
Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser
465                 470                 475                 480 
Met Asn Gly Asp Cys Val Met Tyr Lys Pro Leu Asp Leu Ser Asp Arg
                485                 490                 495     
Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser
            500                 505                 510         
Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile
        515                 520                 525             
Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr
    530                 535                 540                 
Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile
545                 550                 555                 560 
Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln
                565                 570                 575     
Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu
            580                 585                 590         
Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser
        595                 600                 605             
His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu
    610                 615                 620                 
Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys
625                 630                 635                 640 
Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser
                645                 650                 655     
Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val
            660                 665                 670         
Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val
        675                 680                 685             
Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys
    690                 695                 700                 
Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Met Leu Phe Tyr Ile Asp
705                 710                 715                 720 
Glu Glu Arg Lys Met Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr
                725                 730                 735     
Thr His Glu Glu Tyr Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala
            740                 745                 750         
Ala Asp Glu Glu Glu Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr
        755                 760                 765             
His Gly Asp Lys Gln Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro
    770                 775                 780                 
Tyr Phe Lys Gly Asp Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His
785                 790                 795                 800 
Ile Glu Val Val Arg Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His
                805                 810                 815     
Thr Cys Lys Glu Cys Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu
            820                 825                 830         
Arg Glu Lys Lys Leu Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile
        835                 840                 845             
Pro Pro Asn Thr Pro Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr
    850                 855                 860                 
Gln Thr Cys Met Glu Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys
865                 870                 875                 880 
Pro Arg Pro Lys Arg Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys
                885                 890                 895     
Gly Lys Glu Gln Lys Thr
            900         


<210> 6075
<211> 897
<212> PRT
<213> Homo sapiens

<400> 6075
Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr
 1               5                  10                  15      
Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp
            20                  25                  30          
Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu
        35                  40                  45              
Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln
    50                  55                  60                  
Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu
65                  70                  75                  80  
Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu
                85                  90                  95      
Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln
            100                 105                 110         
Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln
        115                 120                 125             
Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn
    130                 135                 140                 
Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile
145                 150                 155                 160 
Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu
                165                 170                 175     
Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr
            180                 185                 190         
Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys
        195                 200                 205             
Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val
    210                 215                 220                 
Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly
225                 230                 235                 240 
Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val
                245                 250                 255     
Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln
            260                 265                 270         
Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly
        275                 280                 285             
Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp
    290                 295                 300                 
Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu
305                 310                 315                 320 
Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile
                325                 330                 335     
Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln
            340                 345                 350         
Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys
        355                 360                 365             
Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu
    370                 375                 380                 
Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln
385                 390                 395                 400 
Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu
                405                 410                 415     
Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys
            420                 425                 430         
His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys
        435                 440                 445             
Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser
    450                 455                 460                 
Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser
465                 470                 475                 480 
Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg
                485                 490                 495     
Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser
            500                 505                 510         
Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile
        515                 520                 525             
Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr
    530                 535                 540                 
Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile
545                 550                 555                 560 
Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln
                565                 570                 575     
Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu
            580                 585                 590         
Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser
        595                 600                 605             
His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu
    610                 615                 620                 
Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys
625                 630                 635                 640 
Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser
                645                 650                 655     
Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val
            660                 665                 670         
Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val
        675                 680                 685             
Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys
    690                 695                 700                 
Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met
705                 710                 715                 720 
Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr
                725                 730                 735     
Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu
            740                 745                 750         
Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln
        755                 760                 765             
Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp
    770                 775                 780                 
Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg
785                 790                 795                 800 
Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys
                805                 810                 815     
Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu
            820                 825                 830         
Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro
        835                 840                 845             
Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu
    850                 855                 860                 
Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg
865                 870                 875                 880 
Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys
                885                 890                 895     
Thr
    


<210> 6076
<211> 693
<212> PRT
<213> Homo sapiens

<400> 6076
Met Ala Ala Leu Gly Val Gln Ser Ile Asn Trp Gln Thr Ala Phe Asn
 1               5                  10                  15      
Arg Gln Ala His His Thr Asp Lys Phe Ser Ser Gln Glu Leu Ile Leu
            20                  25                  30          
Arg Arg Gly Gln Asn Phe Gln Val Leu Met Ile Met Asn Lys Gly Leu
        35                  40                  45              
Gly Ser Asn Glu Arg Leu Glu Phe Ile Val Ser Thr Gly Pro Tyr Pro
    50                  55                  60                  
Ser Glu Ser Ala Met Thr Lys Ala Val Phe Pro Leu Ser Asn Gly Ser
65                  70                  75                  80  
Ser Gly Gly Trp Ser Ala Val Leu Gln Ala Ser Asn Gly Asn Thr Leu
                85                  90                  95      
Thr Ile Ser Ile Ser Ser Pro Ala Ser Ala Pro Ile Gly Arg Tyr Thr
            100                 105                 110         
Met Ala Leu Gln Ile Phe Ser Gln Gly Gly Ile Ser Ser Val Lys Leu
        115                 120                 125             
Gly Thr Phe Ile Leu Leu Phe Asn Pro Trp Leu Asn Val Asp Ser Val
    130                 135                 140                 
Phe Met Gly Asn His Ala Glu Arg Glu Glu Tyr Val Gln Glu Asp Ala
145                 150                 155                 160 
Gly Ile Ile Phe Val Gly Ser Thr Asn Arg Ile Gly Met Ile Gly Trp
                165                 170                 175     
Asn Phe Gly Gln Phe Glu Glu Asp Ile Leu Ser Ile Cys Leu Ser Ile
            180                 185                 190         
Leu Asp Arg Ser Leu Asn Phe Arg Arg Asp Ala Ala Thr Asp Val Ala
        195                 200                 205             
Ser Arg Asn Asp Pro Lys Tyr Val Gly Arg Val Leu Ser Ala Met Ile
    210                 215                 220                 
Asn Ser Asn Asp Asp Asn Gly Val Leu Ala Gly Asn Trp Ser Gly Thr
225                 230                 235                 240 
Tyr Thr Gly Gly Arg Asp Pro Arg Ser Trp Asn Gly Ser Val Glu Ile
                245                 250                 255     
Leu Lys Asn Trp Lys Lys Ser Gly Phe Ser Pro Val Arg Tyr Gly Gln
            260                 265                 270         
Cys Trp Val Phe Ala Gly Thr Leu Asn Thr Ala Leu Arg Ser Leu Gly
        275                 280                 285             
Ile Pro Ser Arg Val Ile Thr Asn Phe Asn Ser Ala His Asp Thr Asp
    290                 295                 300                 
Arg Asn Leu Ser Val Asp Val Tyr Tyr Asp Pro Met Gly Asn Pro Leu
305                 310                 315                 320 
Asp Lys Gly Ser Asp Ser Val Trp Asn Phe His Val Trp Asn Glu Gly
                325                 330                 335     
Trp Phe Val Arg Ser Asp Leu Gly Pro Ser Tyr Gly Gly Trp Gln Val
            340                 345                 350         
Leu Asp Ala Thr Pro Gln Glu Arg Ser Gln Gly Val Phe Gln Cys Gly
        355                 360                 365             
Pro Ala Ser Val Ile Gly Val Arg Glu Gly Asp Val Gln Leu Asn Phe
    370                 375                 380                 
Asp Met Pro Phe Ile Phe Ala Glu Val Asn Ala Asp Arg Ile Thr Trp
385                 390                 395                 400 
Leu Tyr Asp Asn Thr Thr Gly Lys Gln Trp Lys Asn Ser Val Asn Ser
                405                 410                 415     
His Thr Ile Gly Arg Tyr Ile Ser Thr Lys Ala Val Gly Ser Asn Ala
            420                 425                 430         
Arg Met Asp Val Thr Asp Lys Tyr Lys Tyr Pro Glu Gly Ser Asp Gln
        435                 440                 445             
Glu Arg Gln Val Phe Gln Lys Ala Leu Gly Lys Leu Lys Pro Asn Thr
    450                 455                 460                 
Pro Phe Ala Ala Thr Ser Ser Met Gly Leu Glu Thr Glu Glu Gln Glu
465                 470                 475                 480 
Pro Ser Ile Ile Gly Lys Leu Lys Val Ala Gly Met Leu Ala Val Gly
                485                 490                 495     
Lys Glu Val Asn Leu Val Leu Leu Leu Lys Asn Leu Ser Arg Asp Thr
            500                 505                 510         
Lys Thr Val Thr Val Asn Met Thr Ala Trp Thr Ile Ile Tyr Asn Gly
        515                 520                 525             
Thr Leu Val His Glu Val Trp Lys Asp Ser Ala Thr Met Ser Leu Asp
    530                 535                 540                 
Pro Glu Glu Glu Ala Glu His Pro Ile Lys Ile Ser Tyr Ala Gln Tyr
545                 550                 555                 560 
Glu Lys Tyr Leu Lys Ser Asp Asn Met Ile Arg Ile Thr Ala Val Cys
                565                 570                 575     
Lys Val Pro Asp Glu Ser Glu Val Val Val Glu Arg Asp Ile Ile Leu
            580                 585                 590         
Asp Asn Pro Thr Leu Thr Leu Glu Val Leu Asn Glu Ala Arg Val Arg
        595                 600                 605             
Lys Pro Val Asn Val Gln Met Leu Phe Ser Asn Pro Leu Asp Glu Pro
    610                 615                 620                 
Val Arg Asp Cys Val Leu Met Val Glu Gly Ser Gly Leu Leu Leu Gly
625                 630                 635                 640 
Asn Leu Lys Ile Asp Val Pro Thr Leu Gly Pro Lys Glu Gly Ser Arg
                645                 650                 655     
Val Arg Phe Asp Ile Leu Pro Ser Arg Ser Gly Thr Lys Gln Leu Leu
            660                 665                 670         
Ala Asp Phe Ser Cys Asn Lys Phe Pro Ala Ile Lys Ala Met Leu Ser
        675                 680                 685             
Ile Asp Val Ala Glu
    690             


<210> 6077
<211> 2839
<212> PRT
<213> Homo sapiens

<400> 6077
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg
 1               5                  10                  15      
Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr
            20                  25                  30          
Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys
        35                  40                  45              
Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn
    50                  55                  60                  
Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr
65                  70                  75                  80  
Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly
                85                  90                  95      
Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln
            100                 105                 110         
Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn
        115                 120                 125             
Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser
    130                 135                 140                 
Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg
145                 150                 155                 160 
Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp
                165                 170                 175     
Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg
            180                 185                 190         
Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala
        195                 200                 205             
Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val
    210                 215                 220                 
Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr
225                 230                 235                 240 
Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe
                245                 250                 255     
Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile
            260                 265                 270         
Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val
        275                 280                 285             
Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg
    290                 295                 300                 
Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala
305                 310                 315                 320 
Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp
                325                 330                 335     
Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp
            340                 345                 350         
Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser
        355                 360                 365             
Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe
    370                 375                 380                 
Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln
385                 390                 395                 400 
Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg
                405                 410                 415     
Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val
            420                 425                 430         
Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His
        435                 440                 445             
Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro
    450                 455                 460                 
Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys
465                 470                 475                 480 
Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met
                485                 490                 495     
Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg
            500                 505                 510         
Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly
        515                 520                 525             
Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu
    530                 535                 540                 
Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu
545                 550                 555                 560 
Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln
                565                 570                 575     
Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser
            580                 585                 590         
Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn
        595                 600                 605             
Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe
    610                 615                 620                 
Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr
625                 630                 635                 640 
Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala
                645                 650                 655     
Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly
            660                 665                 670         
Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu
        675                 680                 685             
Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu
    690                 695                 700                 
Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg
705                 710                 715                 720 
Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn
                725                 730                 735     
Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg
            740                 745                 750         
Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His
        755                 760                 765             
Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp
    770                 775                 780                 
Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu
785                 790                 795                 800 
Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg
                805                 810                 815     
Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp
            820                 825                 830         
Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly
        835                 840                 845             
Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser
    850                 855                 860                 
Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val
865                 870                 875                 880 
Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp
                885                 890                 895     
Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln
            900                 905                 910         
Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala
        915                 920                 925             
Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe
    930                 935                 940                 
Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe
945                 950                 955                 960 
Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr
                965                 970                 975     
Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met
            980                 985                 990         
Leu Asn Leu Val Arg Tyr Val Arg Val Leu Gly Asn Met Val His Ala
        995                 1000                1005            
Ile Gln Ile Lys Thr Lys Leu Cys Gln Leu Val Glu Val Met Met Ala
    1010                1015                1020                
Arg Arg Asp Asp Leu Ser Phe Cys Gln Glu Met Lys Phe Arg Asn Lys
1025                1030                1035                1040
Met Val Glu Tyr Leu Thr Asp Trp Val Met Gly Thr Ser Asn Gln Ala
                1045                1050                1055    
Ala Asp Asp Asp Val Lys Cys Leu Thr Arg Asp Leu Asp Gln Ala Ser
            1060                1065                1070        
Met Glu Ala Val Val Ser Leu Leu Ala Gly Leu Pro Leu Gln Pro Glu
        1075                1080                1085            
Glu Gly Asp Gly Val Glu Leu Met Glu Ala Lys Ser Gln Leu Phe Leu
    1090                1095                1100                
Lys Tyr Phe Thr Leu Phe Met Asn Leu Leu Asn Asp Cys Ser Glu Val
1105                1110                1115                1120
Glu Asp Glu Ser Ala Gln Thr Gly Gly Arg Lys Arg Gly Met Ser Arg
                1125                1130                1135    
Arg Leu Ala Ser Leu Arg His Cys Thr Val Leu Ala Met Ser Asn Leu
            1140                1145                1150        
Leu Asn Ala Asn Val Asp Ser Gly Leu Met His Ser Ile Gly Leu Gly
        1155                1160                1165            
Tyr His Lys Asp Leu Gln Thr Arg Ala Thr Phe Met Glu Val Leu Thr
    1170                1175                1180                
Lys Ile Leu Gln Gln Gly Thr Glu Phe Asp Thr Leu Ala Glu Thr Val
1185                1190                1195                1200
Leu Ala Asp Arg Phe Glu Arg Leu Val Glu Leu Val Thr Met Met Gly
                1205                1210                1215    
Asp Gln Gly Glu Leu Pro Ile Ala Met Ala Leu Ala Asn Val Val Pro
            1220                1225                1230        
Cys Ser Gln Trp Asp Glu Leu Ala Arg Val Leu Val Thr Leu Phe Asp
        1235                1240                1245            
Ser Arg His Leu Leu Tyr Gln Leu Leu Trp Asn Met Phe Ser Lys Glu
    1250                1255                1260                
Val Glu Leu Ala Asp Ser Met Gln Thr Leu Phe Arg Gly Asn Ser Leu
1265                1270                1275                1280
Ala Ser Lys Ile Met Thr Phe Cys Phe Lys Val Tyr Gly Ala Thr Tyr
                1285                1290                1295    
Leu Gln Lys Leu Leu Asp Pro Leu Leu Arg Ile Val Ile Thr Ser Ser
            1300                1305                1310        
Asp Trp Gln His Val Ser Phe Glu Val Asp Pro Thr Arg Leu Glu Pro
        1315                1320                1325            
Ser Glu Ser Leu Glu Glu Asn Gln Arg Asn Leu Leu Gln Met Thr Glu
    1330                1335                1340                
Lys Phe Phe His Ala Ile Ile Ser Ser Ser Ser Glu Phe Pro Pro Gln
1345                1350                1355                1360
Leu Arg Ser Val Cys His Cys Leu Tyr Gln Ala Thr Cys His Ser Leu
                1365                1370                1375    
Leu Asn Lys Ala Thr Val Lys Glu Lys Lys Glu Asn Lys Lys Ser Val
            1380                1385                1390        
Val Ser Gln Arg Phe Pro Gln Asn Ser Ile Gly Ala Val Gly Ser Ala
        1395                1400                1405            
Met Phe Leu Arg Phe Ile Asn Pro Ala Ile Val Ser Pro Tyr Glu Ala
    1410                1415                1420                
Gly Ile Leu Asp Lys Lys Pro Pro Pro Arg Ile Glu Arg Gly Leu Lys
1425                1430                1435                1440
Leu Met Ser Lys Ile Leu Gln Ser Ile Ala Asn His Val Leu Phe Thr
                1445                1450                1455    
Lys Glu Glu His Met Arg Pro Phe Asn Asp Phe Val Lys Ser Asn Phe
            1460                1465                1470        
Asp Ala Ala Arg Arg Phe Phe Leu Asp Ile Ala Ser Asp Cys Pro Thr
        1475                1480                1485            
Ser Asp Ala Val Asn His Ser Leu Ser Phe Ile Ser Asp Gly Asn Val
    1490                1495                1500                
Leu Ala Leu His Arg Leu Leu Trp Asn Asn Gln Glu Lys Ile Gly Gln
1505                1510                1515                1520
Tyr Leu Ser Ser Asn Arg Asp His Lys Ala Val Gly Arg Arg Pro Phe
                1525                1530                1535    
Asp Lys Met Ala Thr Leu Leu Ala Tyr Leu Gly Pro Pro Glu His Lys
            1540                1545                1550        
Pro Val Ala Asp Thr His Trp Ser Ser Leu Asn Leu Thr Ser Ser Lys
        1555                1560                1565            
Phe Glu Glu Phe Met Thr Arg His Gln Val His Glu Lys Glu Glu Phe
    1570                1575                1580                
Lys Ala Leu Lys Thr Leu Ser Ile Phe Tyr Gln Ala Gly Thr Ser Lys
1585                1590                1595                1600
Ala Gly Asn Pro Ile Phe Tyr Tyr Val Ala Arg Arg Phe Lys Thr Gly
                1605                1610                1615    
Gln Ile Asn Gly Asp Leu Leu Ile Tyr His Val Leu Leu Thr Leu Lys
            1620                1625                1630        
Pro Tyr Tyr Ala Lys Pro Tyr Glu Ile Val Val Asp Leu Thr His Thr
        1635                1640                1645            
Gly Pro Ser Asn Arg Phe Lys Thr Asp Phe Leu Ser Lys Trp Phe Val
    1650                1655                1660                
Val Phe Pro Gly Phe Ala Tyr Asp Asn Val Ser Ala Val Tyr Ile Tyr
1665                1670                1675                1680
Asn Cys Asn Ser Trp Val Arg Glu Tyr Thr Lys Tyr His Glu Arg Leu
                1685                1690                1695    
Leu Thr Gly Leu Lys Gly Ser Lys Arg Leu Val Phe Ile Asp Cys Pro
            1700                1705                1710        
Gly Lys Leu Ala Glu His Ile Glu His Glu Gln Gln Lys Leu Pro Ala
        1715                1720                1725            
Ala Thr Leu Ala Leu Glu Glu Asp Leu Lys Val Phe His Asn Ala Leu
    1730                1735                1740                
Lys Leu Ala His Lys Asp Thr Lys Val Ser Ile Lys Val Gly Ser Thr
1745                1750                1755                1760
Ala Val Gln Val Thr Ser Ala Glu Arg Thr Lys Val Leu Gly Gln Ser
                1765                1770                1775    
Val Phe Leu Asn Asp Ile Tyr Tyr Ala Ser Glu Ile Glu Glu Ile Cys
            1780                1785                1790        
Leu Val Asp Glu Asn Gln Phe Thr Leu Thr Ile Ala Asn Gln Gly Thr
        1795                1800                1805            
Pro Leu Thr Phe Met His Gln Glu Cys Glu Ala Ile Val Gln Ser Ile
    1810                1815                1820                
Ile His Ile Arg Thr Arg Trp Glu Leu Ser Gln Pro Asp Ser Ile Pro
1825                1830                1835                1840
Gln His Thr Lys Ile Arg Pro Lys Asp Val Pro Gly Thr Leu Leu Asn
                1845                1850                1855    
Ile Ala Leu Leu Asn Leu Gly Ser Ser Asp Pro Ser Leu Arg Ser Ala
            1860                1865                1870        
Ala Tyr Asn Leu Leu Cys Ala Leu Thr Cys Thr Phe Asn Leu Lys Ile
        1875                1880                1885            
Glu Gly Gln Leu Leu Glu Thr Ser Gly Leu Cys Ile Pro Ala Asn Asn
    1890                1895                1900                
Thr Leu Phe Ile Val Ser Ile Ser Lys Thr Leu Ala Ala Asn Glu Pro
1905                1910                1915                1920
His Leu Thr Leu Glu Phe Leu Glu Glu Cys Ile Ser Gly Phe Ser Lys
                1925                1930                1935    
Ser Ser Ile Glu Leu Lys His Leu Cys Leu Glu Tyr Met Thr Pro Trp
            1940                1945                1950        
Leu Ser Asn Leu Val Arg Phe Cys Lys His Asn Asp Asp Ala Lys Arg
        1955                1960                1965            
Gln Arg Val Thr Ala Ile Leu Asp Lys Leu Ile Thr Met Thr Ile Asn
    1970                1975                1980                
Glu Lys Gln Met Tyr Pro Ser Ile Gln Ala Lys Ile Trp Gly Ser Leu
1985                1990                1995                2000
Gly Gln Ile Thr Asp Leu Leu Asp Val Val Leu Asp Ser Phe Ile Lys
                2005                2010                2015    
Thr Ser Ala Thr Gly Gly Leu Gly Ser Ile Lys Ala Glu Val Met Ala
            2020                2025                2030        
Asp Thr Ala Val Ala Leu Ala Ser Gly Asn Val Lys Leu Val Ser Ser
        2035                2040                2045            
Lys Val Ile Gly Arg Met Cys Lys Ile Ile Asp Lys Thr Cys Leu Ser
    2050                2055                2060                
Pro Thr Pro Thr Leu Glu Gln His Leu Met Trp Asp Asp Ile Ala Ile
2065                2070                2075                2080
Leu Ala Arg Tyr Met Leu Met Leu Ser Phe Asn Asn Ser Leu Asp Val
                2085                2090                2095    
Ala Ala His Leu Pro Tyr Leu Phe His Val Val Thr Phe Leu Val Ala
            2100                2105                2110        
Thr Gly Pro Leu Ser Leu Arg Ala Ser Thr His Gly Leu Val Ile Asn
        2115                2120                2125            
Ile Ile His Ser Leu Cys Thr Cys Ser Gln Leu His Phe Ser Glu Glu
    2130                2135                2140                
Thr Lys Gln Val Leu Arg Leu Ser Leu Thr Glu Phe Ser Leu Pro Lys
2145                2150                2155                2160
Phe Tyr Leu Leu Phe Gly Ile Ser Lys Val Lys Ser Ala Ala Val Ile
                2165                2170                2175    
Ala Phe Arg Ser Ser Tyr Arg Asp Arg Ser Phe Ser Pro Gly Ser Tyr
            2180                2185                2190        
Glu Arg Glu Thr Phe Ala Leu Thr Ser Leu Glu Thr Val Thr Glu Ala
        2195                2200                2205            
Leu Leu Glu Ile Met Glu Ala Cys Met Arg Asp Ile Pro Thr Cys Lys
    2210                2215                2220                
Trp Leu Asp Gln Trp Thr Glu Leu Ala Gln Arg Phe Ala Phe Gln Tyr
2225                2230                2235                2240
Asn Pro Ser Leu Gln Pro Arg Ala Leu Val Val Phe Gly Cys Ile Ser
                2245                2250                2255    
Lys Arg Val Ser His Gly Gln Ile Lys Gln Ile Ile Arg Ile Leu Ser
            2260                2265                2270        
Lys Ala Leu Glu Ser Cys Leu Lys Gly Pro Asp Thr Tyr Asn Ser Gln
        2275                2280                2285            
Val Leu Ile Glu Ala Thr Val Ile Ala Leu Thr Lys Leu Gln Pro Leu
    2290                2295                2300                
Leu Asn Lys Asp Ser Pro Leu His Lys Ala Leu Phe Trp Val Ala Val
2305                2310                2315                2320
Ala Val Leu Gln Leu Asp Glu Val Asn Leu Tyr Ser Ala Gly Thr Ala
                2325                2330                2335    
Leu Leu Glu Gln Asn Leu His Thr Leu Asp Ser Leu Arg Ile Phe Asn
            2340                2345                2350        
Asp Lys Ser Pro Glu Glu Val Phe Met Ala Ile Arg Asn Pro Leu Glu
        2355                2360                2365            
Trp His Cys Lys Gln Met Asp His Phe Val Gly Leu Asn Phe Asn Ser
    2370                2375                2380                
Asn Phe Asn Phe Ala Leu Val Gly His Leu Leu Lys Gly Tyr Arg His
2385                2390                2395                2400
Pro Ser Pro Ala Ile Val Ala Arg Thr Val Arg Ile Leu His Thr Leu
                2405                2410                2415    
Leu Thr Leu Val Asn Lys His Arg Asn Cys Asp Lys Phe Glu Val Asn
            2420                2425                2430        
Thr Gln Ser Val Ala Tyr Leu Ala Ala Leu Leu Thr Val Ser Glu Glu
        2435                2440                2445            
Val Arg Ser Arg Cys Ser Leu Lys His Arg Lys Ser Leu Leu Leu Thr
    2450                2455                2460                
Asp Ile Ser Met Glu Asn Val Pro Met Asp Thr Tyr Pro Ile His His
2465                2470                2475                2480
Gly Asp Pro Ser Tyr Arg Thr Leu Lys Glu Thr Gln Pro Trp Ser Ser
                2485                2490                2495    
Pro Lys Gly Ser Glu Gly Tyr Leu Ala Ala Thr Tyr Pro Thr Val Gly
            2500                2505                2510        
Gln Thr Ser Pro Arg Ala Arg Lys Ser Met Ser Leu Asp Met Gly Gln
        2515                2520                2525            
Pro Ser Gln Ala Asn Thr Lys Lys Leu Leu Gly Thr Arg Lys Ser Phe
    2530                2535                2540                
Asp His Leu Ile Ser Asp Thr Lys Ala Pro Lys Arg Gln Glu Met Glu
2545                2550                2555                2560
Ser Gly Ile Thr Thr Pro Pro Lys Met Arg Arg Val Ala Glu Thr Asp
                2565                2570                2575    
Tyr Glu Met Glu Thr Gln Arg Ile Ser Ser Ser Gln Gln His Pro His
            2580                2585                2590        
Leu Arg Lys Val Ser Val Ser Glu Ser Asn Val Leu Leu Asp Glu Glu
        2595                2600                2605            
Val Leu Thr Asp Pro Lys Ile Gln Ala Leu Leu Leu Thr Val Leu Ala
    2610                2615                2620                
Thr Leu Val Lys Tyr Thr Thr Asp Glu Phe Asp Gln Arg Ile Leu Tyr
2625                2630                2635                2640
Glu Tyr Leu Ala Glu Ala Ser Val Val Phe Pro Lys Val Phe Pro Val
                2645                2650                2655    
Val His Asn Leu Leu Asp Ser Lys Ile Asn Thr Leu Leu Ser Leu Cys
            2660                2665                2670        
Gln Asp Pro Asn Leu Leu Asn Pro Ile His Gly Ile Val Gln Ser Val
        2675                2680                2685            
Val Tyr His Glu Glu Ser Pro Pro Gln Tyr Gln Thr Ser Tyr Leu Gln
    2690                2695                2700                
Ser Phe Gly Phe Asn Gly Leu Trp Arg Phe Ala Gly Pro Phe Ser Lys
2705                2710                2715                2720
Gln Thr Gln Ile Pro Asp Tyr Ala Glu Leu Ile Val Lys Phe Leu Asp
                2725                2730                2735    
Ala Leu Ile Asp Thr Tyr Leu Pro Gly Ile Asp Glu Glu Thr Ser Glu
            2740                2745                2750        
Glu Ser Leu Leu Thr Pro Thr Ser Pro Tyr Pro Pro Ala Leu Gln Ser
        2755                2760                2765            
Gln Leu Ser Ile Thr Ala Asn Leu Asn Leu Ser Asn Ser Met Thr Ser
    2770                2775                2780                
Leu Ala Thr Ser Gln His Ser Pro Gly Ile Asp Lys Glu Asn Val Glu
2785                2790                2795                2800
Leu Ser Pro Thr Thr Gly His Cys Asn Ser Gly Arg Thr Arg His Gly
                2805                2810                2815    
Ser Ala Ser Gln Val Gln Lys Gln Arg Ser Ala Gly Ser Phe Lys Arg
            2820                2825                2830        
Asn Ser Ile Lys Lys Ile Val
        2835                


<210> 6078
<211> 2818
<212> PRT
<213> Homo sapiens

<400> 6078
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg
 1               5                  10                  15      
Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr
            20                  25                  30          
Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys
        35                  40                  45              
Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn
    50                  55                  60                  
Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr
65                  70                  75                  80  
Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly
                85                  90                  95      
Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln
            100                 105                 110         
Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn
        115                 120                 125             
Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser
    130                 135                 140                 
Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg
145                 150                 155                 160 
Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp
                165                 170                 175     
Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg
            180                 185                 190         
Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala
        195                 200                 205             
Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val
    210                 215                 220                 
Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr
225                 230                 235                 240 
Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe
                245                 250                 255     
Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile
            260                 265                 270         
Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val
        275                 280                 285             
Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg
    290                 295                 300                 
Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala
305                 310                 315                 320 
Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp
                325                 330                 335     
Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp
            340                 345                 350         
Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser
        355                 360                 365             
Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe
    370                 375                 380                 
Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln
385                 390                 395                 400 
Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg
                405                 410                 415     
Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val
            420                 425                 430         
Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His
        435                 440                 445             
Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro
    450                 455                 460                 
Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys
465                 470                 475                 480 
Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met
                485                 490                 495     
Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg
            500                 505                 510         
Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly
        515                 520                 525             
Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu
    530                 535                 540                 
Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu
545                 550                 555                 560 
Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln
                565                 570                 575     
Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser
            580                 585                 590         
Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn
        595                 600                 605             
Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe
    610                 615                 620                 
Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr
625                 630                 635                 640 
Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala
                645                 650                 655     
Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly
            660                 665                 670         
Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu
        675                 680                 685             
Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu
    690                 695                 700                 
Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg
705                 710                 715                 720 
Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn
                725                 730                 735     
Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg
            740                 745                 750         
Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His
        755                 760                 765             
Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp
    770                 775                 780                 
Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu
785                 790                 795                 800 
Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg
                805                 810                 815     
Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp
            820                 825                 830         
Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly
        835                 840                 845             
Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser
    850                 855                 860                 
Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val
865                 870                 875                 880 
Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp
                885                 890                 895     
Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln
            900                 905                 910         
Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala
        915                 920                 925             
Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe
    930                 935                 940                 
Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe
945                 950                 955                 960 
Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr
                965                 970                 975     
Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met
            980                 985                 990         
Leu Asn Leu Val Arg Tyr Val Arg Val Leu Gly Asn Met Val His Ala
        995                 1000                1005            
Ile Gln Ile Lys Thr Lys Leu Cys Gln Leu Val Glu Val Met Met Ala
    1010                1015                1020                
Arg Arg Asp Asp Leu Ser Phe Cys Gln Glu Met Lys Phe Arg Asn Lys
1025                1030                1035                1040
Met Val Glu Tyr Leu Thr Asp Trp Val Met Gly Thr Ser Asn Gln Ala
                1045                1050                1055    
Ala Asp Asp Asp Val Lys Cys Leu Thr Arg Asp Leu Asp Gln Ala Ser
            1060                1065                1070        
Met Glu Ala Val Val Ser Leu Leu Ala Gly Leu Pro Leu Gln Pro Glu
        1075                1080                1085            
Glu Gly Asp Gly Val Glu Leu Met Glu Ala Lys Ser Gln Leu Phe Leu
    1090                1095                1100                
Lys Tyr Phe Thr Leu Phe Met Asn Leu Leu Asn Asp Cys Ser Glu Val
1105                1110                1115                1120
Glu Asp Glu Ser Ala Gln Thr Gly Gly Arg Lys Arg Gly Met Ser Arg
                1125                1130                1135    
Arg Leu Ala Ser Leu Arg His Cys Thr Val Leu Ala Met Ser Asn Leu
            1140                1145                1150        
Leu Asn Ala Asn Val Asp Ser Gly Leu Met His Ser Ile Gly Leu Gly
        1155                1160                1165            
Tyr His Lys Asp Leu Gln Thr Arg Ala Thr Phe Met Glu Val Leu Thr
    1170                1175                1180                
Lys Ile Leu Gln Gln Gly Thr Glu Phe Asp Thr Leu Ala Glu Thr Val
1185                1190                1195                1200
Leu Ala Asp Arg Phe Glu Arg Leu Val Glu Leu Val Thr Met Met Gly
                1205                1210                1215    
Asp Gln Gly Glu Leu Pro Ile Ala Met Ala Leu Ala Asn Val Val Pro
            1220                1225                1230        
Cys Ser Gln Trp Asp Glu Leu Ala Arg Val Leu Val Thr Leu Phe Asp
        1235                1240                1245            
Ser Arg His Leu Leu Tyr Gln Leu Leu Trp Asn Met Phe Ser Lys Glu
    1250                1255                1260                
Val Glu Leu Ala Asp Ser Met Gln Thr Leu Phe Arg Gly Asn Ser Leu
1265                1270                1275                1280
Ala Ser Lys Ile Met Thr Phe Cys Phe Lys Val Tyr Gly Ala Thr Tyr
                1285                1290                1295    
Leu Gln Lys Leu Leu Asp Pro Leu Leu Arg Ile Val Ile Thr Ser Ser
            1300                1305                1310        
Asp Trp Gln His Val Ser Phe Glu Val Asp Pro Thr Arg Leu Glu Pro
        1315                1320                1325            
Ser Glu Ser Leu Glu Glu Asn Gln Arg Asn Leu Leu Gln Met Thr Glu
    1330                1335                1340                
Lys Phe Phe His Ala Ile Ile Ser Ser Ser Ser Glu Phe Pro Pro Gln
1345                1350                1355                1360
Leu Arg Ser Val Cys His Cys Leu Tyr Gln Val Val Ser Gln Arg Phe
                1365                1370                1375    
Pro Gln Asn Ser Ile Gly Ala Val Gly Ser Ala Met Phe Leu Arg Phe
            1380                1385                1390        
Ile Asn Pro Ala Ile Val Ser Pro Tyr Glu Ala Gly Ile Leu Asp Lys
        1395                1400                1405            
Lys Pro Pro Pro Arg Ile Glu Arg Gly Leu Lys Leu Met Ser Lys Ile
    1410                1415                1420                
Leu Gln Ser Ile Ala Asn His Val Leu Phe Thr Lys Glu Glu His Met
1425                1430                1435                1440
Arg Pro Phe Asn Asp Phe Val Lys Ser Asn Phe Asp Ala Ala Arg Arg
                1445                1450                1455    
Phe Phe Leu Asp Ile Ala Ser Asp Cys Pro Thr Ser Asp Ala Val Asn
            1460                1465                1470        
His Ser Leu Ser Phe Ile Ser Asp Gly Asn Val Leu Ala Leu His Arg
        1475                1480                1485            
Leu Leu Trp Asn Asn Gln Glu Lys Ile Gly Gln Tyr Leu Ser Ser Asn
    1490                1495                1500                
Arg Asp His Lys Ala Val Gly Arg Arg Pro Phe Asp Lys Met Ala Thr
1505                1510                1515                1520
Leu Leu Ala Tyr Leu Gly Pro Pro Glu His Lys Pro Val Ala Asp Thr
                1525                1530                1535    
His Trp Ser Ser Leu Asn Leu Thr Ser Ser Lys Phe Glu Glu Phe Met
            1540                1545                1550        
Thr Arg His Gln Val His Glu Lys Glu Glu Phe Lys Ala Leu Lys Thr
        1555                1560                1565            
Leu Ser Ile Phe Tyr Gln Ala Gly Thr Ser Lys Ala Gly Asn Pro Ile
    1570                1575                1580                
Phe Tyr Tyr Val Ala Arg Arg Phe Lys Thr Gly Gln Ile Asn Gly Asp
1585                1590                1595                1600
Leu Leu Ile Tyr His Val Leu Leu Thr Leu Lys Pro Tyr Tyr Ala Lys
                1605                1610                1615    
Pro Tyr Glu Ile Val Val Asp Leu Thr His Thr Gly Pro Ser Asn Arg
            1620                1625                1630        
Phe Lys Thr Asp Phe Leu Ser Lys Trp Phe Val Val Phe Pro Gly Phe
        1635                1640                1645            
Ala Tyr Asp Asn Val Ser Ala Val Tyr Ile Tyr Asn Cys Asn Ser Trp
    1650                1655                1660                
Val Arg Glu Tyr Thr Lys Tyr His Glu Arg Leu Leu Thr Gly Leu Lys
1665                1670                1675                1680
Gly Ser Lys Arg Leu Val Phe Ile Asp Cys Pro Gly Lys Leu Ala Glu
                1685                1690                1695    
His Ile Glu His Glu Gln Gln Lys Leu Pro Ala Ala Thr Leu Ala Leu
            1700                1705                1710        
Glu Glu Asp Leu Lys Val Phe His Asn Ala Leu Lys Leu Ala His Lys
        1715                1720                1725            
Asp Thr Lys Val Ser Ile Lys Val Gly Ser Thr Ala Val Gln Val Thr
    1730                1735                1740                
Ser Ala Glu Arg Thr Lys Val Leu Gly Gln Ser Val Phe Leu Asn Asp
1745                1750                1755                1760
Ile Tyr Tyr Ala Ser Glu Ile Glu Glu Ile Cys Leu Val Asp Glu Asn
                1765                1770                1775    
Gln Phe Thr Leu Thr Ile Ala Asn Gln Gly Thr Pro Leu Thr Phe Met
            1780                1785                1790        
His Gln Glu Cys Glu Ala Ile Val Gln Ser Ile Ile His Ile Arg Thr
        1795                1800                1805            
Arg Trp Glu Leu Ser Gln Pro Asp Ser Ile Pro Gln His Thr Lys Ile
    1810                1815                1820                
Arg Pro Lys Asp Val Pro Gly Thr Leu Leu Asn Ile Ala Leu Leu Asn
1825                1830                1835                1840
Leu Gly Ser Ser Asp Pro Ser Leu Arg Ser Ala Ala Tyr Asn Leu Leu
                1845                1850                1855    
Cys Ala Leu Thr Cys Thr Phe Asn Leu Lys Ile Glu Gly Gln Leu Leu
            1860                1865                1870        
Glu Thr Ser Gly Leu Cys Ile Pro Ala Asn Asn Thr Leu Phe Ile Val
        1875                1880                1885            
Ser Ile Ser Lys Thr Leu Ala Ala Asn Glu Pro His Leu Thr Leu Glu
    1890                1895                1900                
Phe Leu Glu Glu Cys Ile Ser Gly Phe Ser Lys Ser Ser Ile Glu Leu
1905                1910                1915                1920
Lys His Leu Cys Leu Glu Tyr Met Thr Pro Trp Leu Ser Asn Leu Val
                1925                1930                1935    
Arg Phe Cys Lys His Asn Asp Asp Ala Lys Arg Gln Arg Val Thr Ala
            1940                1945                1950        
Ile Leu Asp Lys Leu Ile Thr Met Thr Ile Asn Glu Lys Gln Met Tyr
        1955                1960                1965            
Pro Ser Ile Gln Ala Lys Ile Trp Gly Ser Leu Gly Gln Ile Thr Asp
    1970                1975                1980                
Leu Leu Asp Val Val Leu Asp Ser Phe Ile Lys Thr Ser Ala Thr Gly
1985                1990                1995                2000
Gly Leu Gly Ser Ile Lys Ala Glu Val Met Ala Asp Thr Ala Val Ala
                2005                2010                2015    
Leu Ala Ser Gly Asn Val Lys Leu Val Ser Ser Lys Val Ile Gly Arg
            2020                2025                2030        
Met Cys Lys Ile Ile Asp Lys Thr Cys Leu Ser Pro Thr Pro Thr Leu
        2035                2040                2045            
Glu Gln His Leu Met Trp Asp Asp Ile Ala Ile Leu Ala Arg Tyr Met
    2050                2055                2060                
Leu Met Leu Ser Phe Asn Asn Ser Leu Asp Val Ala Ala His Leu Pro
2065                2070                2075                2080
Tyr Leu Phe His Val Val Thr Phe Leu Val Ala Thr Gly Pro Leu Ser
                2085                2090                2095    
Leu Arg Ala Ser Thr His Gly Leu Val Ile Asn Ile Ile His Ser Leu
            2100                2105                2110        
Cys Thr Cys Ser Gln Leu His Phe Ser Glu Glu Thr Lys Gln Val Leu
        2115                2120                2125            
Arg Leu Ser Leu Thr Glu Phe Ser Leu Pro Lys Phe Tyr Leu Leu Phe
    2130                2135                2140                
Gly Ile Ser Lys Val Lys Ser Ala Ala Val Ile Ala Phe Arg Ser Ser
2145                2150                2155                2160
Tyr Arg Asp Arg Ser Phe Ser Pro Gly Ser Tyr Glu Arg Glu Thr Phe
                2165                2170                2175    
Ala Leu Thr Ser Leu Glu Thr Val Thr Glu Ala Leu Leu Glu Ile Met
            2180                2185                2190        
Glu Ala Cys Met Arg Asp Ile Pro Thr Cys Lys Trp Leu Asp Gln Trp
        2195                2200                2205            
Thr Glu Leu Ala Gln Arg Phe Ala Phe Gln Tyr Asn Pro Ser Leu Gln
    2210                2215                2220                
Pro Arg Ala Leu Val Val Phe Gly Cys Ile Ser Lys Arg Val Ser His
2225                2230                2235                2240
Gly Gln Ile Lys Gln Ile Ile Arg Ile Leu Ser Lys Ala Leu Glu Ser
                2245                2250                2255    
Cys Leu Lys Gly Pro Asp Thr Tyr Asn Ser Gln Val Leu Ile Glu Ala
            2260                2265                2270        
Thr Val Ile Ala Leu Thr Lys Leu Gln Pro Leu Leu Asn Lys Asp Ser
        2275                2280                2285            
Pro Leu His Lys Ala Leu Phe Trp Val Ala Val Ala Val Leu Gln Leu
    2290                2295                2300                
Asp Glu Val Asn Leu Tyr Ser Ala Gly Thr Ala Leu Leu Glu Gln Asn
2305                2310                2315                2320
Leu His Thr Leu Asp Ser Leu Arg Ile Phe Asn Asp Lys Ser Pro Glu
                2325                2330                2335    
Glu Val Phe Met Ala Ile Arg Asn Pro Leu Glu Trp His Cys Lys Gln
            2340                2345                2350        
Met Asp His Phe Val Gly Leu Asn Phe Asn Ser Asn Phe Asn Phe Ala
        2355                2360                2365            
Leu Val Gly His Leu Leu Lys Gly Tyr Arg His Pro Ser Pro Ala Ile
    2370                2375                2380                
Val Ala Arg Thr Val Arg Ile Leu His Thr Leu Leu Thr Leu Val Asn
2385                2390                2395                2400
Lys His Arg Asn Cys Asp Lys Phe Glu Val Asn Thr Gln Ser Val Ala
                2405                2410                2415    
Tyr Leu Ala Ala Leu Leu Thr Val Ser Glu Glu Val Arg Ser Arg Cys
            2420                2425                2430        
Ser Leu Lys His Arg Lys Ser Leu Leu Leu Thr Asp Ile Ser Met Glu
        2435                2440                2445            
Asn Val Pro Met Asp Thr Tyr Pro Ile His His Gly Asp Pro Ser Tyr
    2450                2455                2460                
Arg Thr Leu Lys Glu Thr Gln Pro Trp Ser Ser Pro Lys Gly Ser Glu
2465                2470                2475                2480
Gly Tyr Leu Ala Ala Thr Tyr Pro Thr Val Gly Gln Thr Ser Pro Arg
                2485                2490                2495    
Ala Arg Lys Ser Met Ser Leu Asp Met Gly Gln Pro Ser Gln Ala Asn
            2500                2505                2510        
Thr Lys Lys Leu Leu Gly Thr Arg Lys Ser Phe Asp His Leu Ile Ser
        2515                2520                2525            
Asp Thr Lys Ala Pro Lys Arg Gln Glu Met Glu Ser Gly Ile Thr Thr
    2530                2535                2540                
Pro Pro Lys Met Arg Arg Val Ala Glu Thr Asp Tyr Glu Met Glu Thr
2545                2550                2555                2560
Gln Arg Ile Ser Ser Ser Gln Gln His Pro His Leu Arg Lys Val Ser
                2565                2570                2575    
Val Ser Glu Ser Asn Val Leu Leu Asp Glu Glu Val Leu Thr Asp Pro
            2580                2585                2590        
Lys Ile Gln Ala Leu Leu Leu Thr Val Leu Ala Thr Leu Val Lys Tyr
        2595                2600                2605            
Thr Thr Asp Glu Phe Asp Gln Arg Ile Leu Tyr Glu Tyr Leu Ala Glu
    2610                2615                2620                
Ala Ser Val Val Phe Pro Lys Val Phe Pro Val Val His Asn Leu Leu
2625                2630                2635                2640
Asp Ser Lys Ile Asn Thr Leu Leu Ser Leu Cys Gln Asp Pro Asn Leu
                2645                2650                2655    
Leu Asn Pro Ile His Gly Ile Val Gln Ser Val Val Tyr His Glu Glu
            2660                2665                2670        
Ser Pro Pro Gln Tyr Gln Thr Ser Tyr Leu Gln Ser Phe Gly Phe Asn
        2675                2680                2685            
Gly Leu Trp Arg Phe Ala Gly Pro Phe Ser Lys Gln Thr Gln Ile Pro
    2690                2695                2700                
Asp Tyr Ala Glu Leu Ile Val Lys Phe Leu Asp Ala Leu Ile Asp Thr
2705                2710                2715                2720
Tyr Leu Pro Gly Ile Asp Glu Glu Thr Ser Glu Glu Ser Leu Leu Thr
                2725                2730                2735    
Pro Thr Ser Pro Tyr Pro Pro Ala Leu Gln Ser Gln Leu Ser Ile Thr
            2740                2745                2750        
Ala Asn Leu Asn Leu Ser Asn Ser Met Thr Ser Leu Ala Thr Ser Gln
        2755                2760                2765            
His Ser Pro Gly Ile Asp Lys Glu Asn Val Glu Leu Ser Pro Thr Thr
    2770                2775                2780                
Gly His Cys Asn Ser Gly Arg Thr Arg His Gly Ser Ala Ser Gln Val
2785                2790                2795                2800
Gln Lys Gln Arg Ser Ala Gly Ser Phe Lys Arg Asn Ser Ile Lys Lys
                2805                2810                2815    
Ile Val
        


<210> 6079
<211> 1839
<212> PRT
<213> Homo sapiens

<400> 6079
Met Tyr His Ile Asp Cys Arg Asp Gln Leu Glu Arg Val Phe Leu Arg
 1               5                  10                  15      
Leu Gly His Ala Glu Thr Asp Glu Gln Leu Gln Asn Ile Ile Ser Lys
            20                  25                  30          
Phe Leu Pro Pro Val Leu Leu Lys Leu Ser Ser Thr Gln Glu Gly Val
        35                  40                  45              
Arg Lys Lys Val Met Glu Leu Leu Val His Leu Asn Lys Arg Ile Lys
    50                  55                  60                  
Ser Arg Pro Lys Ile Gln Leu Pro Val Glu Thr Leu Leu Val Gln Tyr
65                  70                  75                  80  
Gln Asp Pro Ala Ala Val Ser Phe Val Thr Asn Phe Thr Ile Ile Tyr
                85                  90                  95      
Val Lys Met Gly Tyr Pro Arg Leu Pro Val Glu Lys Gln Cys Glu Leu
            100                 105                 110         
Ala Pro Thr Leu Leu Thr Ala Met Glu Gly Lys Pro Gln Pro Gln Gln
        115                 120                 125             
Asp Ser Leu Met His Leu Leu Ile Pro Thr Leu Phe His Met Lys Tyr
    130                 135                 140                 
Pro Val Glu Ser Ser Lys Ser Ala Ser Pro Phe Asn Leu Ala Glu Lys
145                 150                 155                 160 
Pro Lys Thr Val Gln Leu Leu Leu Asp Phe Met Leu Asp Val Leu Leu
                165                 170                 175     
Met Pro Tyr Gly Tyr Val Leu Asn Glu Ser Gln Ser Arg Gln Asn Ser
            180                 185                 190         
Ser Ser Ala Gln Gly Ser Ser Ser Asn Ser Gly Gly Gly Ser Gly Ile
        195                 200                 205             
Pro Gln Pro Pro Pro Gly Met Ser Phe Tyr Ala Ala Lys Arg Val Ile
    210                 215                 220                 
Gly Asp Asn Pro Trp Thr Pro Glu Gln Leu Glu Gln Cys Lys Leu Gly
225                 230                 235                 240 
Ile Val Lys Phe Ile Glu Ala Glu Gln Val Pro Glu Leu Glu Ala Val
                245                 250                 255     
Leu His Leu Val Ile Ala Ser Ser Asp Thr Arg His Ser Val Ala Thr
            260                 265                 270         
Ala Ala Asp Leu Glu Leu Lys Ser Lys Gln Ser Leu Ile Asp Trp Asn
        275                 280                 285             
Asn Pro Ala Ile Ile Asn Lys Met Tyr Lys Val Tyr Leu Gly Asp Ile
    290                 295                 300                 
Pro Leu Lys Thr Lys Glu Gly Ala Val Leu Lys Pro Glu Leu Lys Arg
305                 310                 315                 320 
Asp Pro Val Ser Thr Arg Val Lys Leu Lys Ile Val Pro His Leu Leu
                325                 330                 335     
Arg Ser Arg Gln Ala Ala Glu Thr Phe Pro Ala Asn Ile Gln Val Val
            340                 345                 350         
Tyr Asp Gly Leu Phe Gly Thr Asn Thr Asn Ser Lys Leu Arg Thr Leu
        355                 360                 365             
Ser Leu Gln Phe Val His His Ile Cys Ile Thr Cys Pro Glu Ile Lys
    370                 375                 380                 
Ile Lys Pro Leu Gly Pro Met Leu Leu Asn Gly Leu Thr Lys Leu Ile
385                 390                 395                 400 
Asn Glu Tyr Lys Glu Asp Pro Lys Leu Leu Ser Met Ala Tyr Ser Ala
                405                 410                 415     
Val Gly Lys Leu Ser Ser Arg Met Pro His Leu Phe Thr Lys Asp Ile
            420                 425                 430         
Ala Leu Val Gln Gln Leu Phe Glu Ala Leu Cys Lys Glu Glu Pro Glu
        435                 440                 445             
Thr Arg Leu Ala Ile Gln Glu Ala Leu Ser Met Met Val Gly Ala Tyr
    450                 455                 460                 
Ser Thr Leu Glu Gly Ala Gln Arg Thr Leu Met Glu Ala Leu Val Ala
465                 470                 475                 480 
Ser Tyr Leu Ile Lys Pro Glu Val Gln Val Arg Gln Val Ala Val Lys
                485                 490                 495     
Phe Ala Ser Thr Val Phe Pro Ser Asp His Ile Pro Ser Arg Tyr Leu
            500                 505                 510         
Leu Leu Leu Ala Ala Gly Asp Pro Arg Glu Glu Val His Gly Glu Ala
        515                 520                 525             
Gln Arg Val Leu Arg Cys Leu Pro Gly Arg Asn Arg Lys Glu Ser Thr
    530                 535                 540                 
Ser Glu Gln Met Pro Ser Phe Pro Glu Met Val Tyr Tyr Ile Gln Glu
545                 550                 555                 560 
Lys Ala Ser His Arg Met Lys Thr Pro Val Lys Tyr Met Thr Gly Thr
                565                 570                 575     
Thr Val Leu Pro Phe Asn Pro Ala Ala Phe Gly Glu Ile Val Leu Tyr
            580                 585                 590         
Leu Arg Met Cys Leu Ala His Ser Ala Gly Val Val Pro Thr Ser Gln
        595                 600                 605             
Ser Leu Ala Asp Met Gln Asp His Ala Pro Ala Ile Gly Arg Tyr Ile
    610                 615                 620                 
Arg Thr Leu Met Ser Ser Gly Gln Met Ala Pro Ser Ser Ser Asn Lys
625                 630                 635                 640 
Ser Gly Glu Thr Asn Pro Val Gln Ile Tyr Ile Gly Leu Leu Gln Gln
                645                 650                 655     
Leu Leu Ala Gly Val Gly Gly Leu Pro Val Met Tyr Cys Leu Leu Glu
            660                 665                 670         
Ala Val Ser Val Tyr Pro Glu Lys Leu Ala Thr Lys Phe Val Asp Lys
        675                 680                 685             
Thr Glu Trp Ile Lys Ser Leu Met Asn Asn Ser Lys Glu Glu Met Arg
    690                 695                 700                 
Glu Leu Ala Ala Leu Phe Tyr Ser Val Val Val Ser Thr Val Ser Gly
705                 710                 715                 720 
Asn Glu Leu Lys Ser Met Ile Glu Gln Leu Ile Lys Thr Thr Lys Asp
                725                 730                 735     
Asn His Ser Pro Glu Ile Gln His Gly Ser Leu Leu Ala Leu Gly Phe
            740                 745                 750         
Thr Val Gly Arg Tyr Leu Ala Lys Lys Lys Met Arg Met Ser Glu Gln
        755                 760                 765             
Gln Asp Leu Glu Arg Asn Ala Asp Thr Leu Pro Asp Gln Glu Glu Leu
    770                 775                 780                 
Ile Gln Ser Ala Thr Glu Thr Ile Gly Ser Phe Leu Asp Ser Thr Ser
785                 790                 795                 800 
Pro Leu Leu Ala Ile Ala Ala Cys Thr Ala Leu Gly Glu Ile Gly Arg
                805                 810                 815     
Asn Gly Pro Leu Pro Ile Pro Ser Glu Gly Ser Gly Phe Thr Lys Leu
            820                 825                 830         
His Leu Val Glu Ser Leu Leu Ser Arg Ile Pro Ser Ser Lys Glu Thr
        835                 840                 845             
Asn Lys Met Lys Glu Arg Ala Ile Gln Thr Leu Gly Tyr Phe Pro Val
    850                 855                 860                 
Gly Asp Gly Asp Phe Pro His Gln Lys Leu Leu Leu Gln Gly Leu Met
865                 870                 875                 880 
Asp Ser Val Glu Ala Lys Gln Ile Glu Leu Gln Phe Thr Ile Gly Glu
                885                 890                 895     
Ala Ile Thr Ser Ala Ala Ile Gly Thr Ser Ser Val Ala Ala Arg Asp
            900                 905                 910         
Ala Trp Gln Met Thr Glu Glu Glu Tyr Thr Pro Pro Ala Gly Ala Lys
        915                 920                 925             
Val Asn Asp Val Val Pro Trp Val Leu Asp Val Ile Leu Asn Lys His
    930                 935                 940                 
Ile Ile Ser Pro Asn Pro His Val Arg Gln Ala Ala Cys Ile Trp Leu
945                 950                 955                 960 
Leu Ser Leu Val Arg Lys Leu Ser Thr His Lys Glu Val Lys Ser His
                965                 970                 975     
Leu Lys Glu Ile Gln Ser Ala Phe Val Ser Val Leu Ser Glu Asn Asp
            980                 985                 990         
Glu Leu Ser Gln Asp Val Ala Ser Lys Gly Leu Gly Leu Val Tyr Glu
        995                 1000                1005            
Leu Gly Asn Glu Gln Asp Gln Gln Glu Leu Val Ser Thr Leu Val Glu
    1010                1015                1020                
Thr Leu Met Thr Gly Lys Arg Val Lys His Glu Val Ser Gly Glu Thr
1025                1030                1035                1040
Val Val Phe Gln Gly Gly Ala Leu Gly Lys Thr Pro Asp Gly Gln Gly
                1045                1050                1055    
Leu Ser Thr Tyr Lys Glu Leu Cys Ser Leu Ala Ser Asp Leu Ser Gln
            1060                1065                1070        
Pro Asp Leu Val Tyr Lys Phe Met Asn Leu Ala Asn His His Ala Met
        1075                1080                1085            
Trp Asn Ser Arg Lys Gly Ala Ala Phe Gly Phe Asn Val Ile Ala Thr
    1090                1095                1100                
Arg Ala Gly Glu Gln Leu Ala Pro Phe Leu Pro Gln Leu Val Pro Arg
1105                1110                1115                1120
Leu Tyr Arg Tyr Gln Phe Asp Pro Asn Leu Gly Ile Arg Gln Ala Met
                1125                1130                1135    
Thr Ser Ile Trp Asn Ala Leu Val Thr Asp Lys Ser Met Val Asp Lys
            1140                1145                1150        
Tyr Leu Lys Glu Ile Leu Gln Asp Leu Val Lys Asn Leu Thr Ser Asn
        1155                1160                1165            
Met Trp Arg Val Arg Glu Ser Ser Cys Leu Ala Leu Asn Asp Leu Leu
    1170                1175                1180                
Arg Gly Arg Pro Leu Asp Asp Ile Ile Asp Lys Leu Pro Glu Ile Trp
1185                1190                1195                1200
Glu Thr Leu Phe Arg Val Gln Asp Asp Ile Lys Glu Ser Val Arg Lys
                1205                1210                1215    
Ala Ala Glu Leu Ala Leu Lys Thr Leu Ser Lys Val Cys Val Lys Met
            1220                1225                1230        
Cys Asp Pro Ala Lys Gly Ala Ala Gly Gln Arg Thr Ile Ala Ala Leu
        1235                1240                1245            
Leu Pro Cys Leu Leu Asp Lys Gly Met Met Ser Thr Val Thr Glu Val
    1250                1255                1260                
Arg Ala Leu Ser Ile Asn Thr Leu Val Lys Ile Ser Lys Ser Ala Gly
1265                1270                1275                1280
Ala Met Leu Lys Pro His Ala Pro Lys Leu Ile Pro Ala Leu Leu Glu
                1285                1290                1295    
Ser Leu Ser Val Leu Glu Pro Gln Val Leu Asn Tyr Leu Ser Leu Arg
            1300                1305                1310        
Ala Thr Glu Gln Glu Lys Ala Ala Met Asp Ser Ala Arg Leu Ser Ala
        1315                1320                1325            
Ala Lys Ser Ser Pro Met Met Glu Thr Ile Asn Met Cys Leu Gln Tyr
    1330                1335                1340                
Leu Asp Val Ser Val Leu Gly Glu Leu Val Pro Arg Leu Cys Glu Leu
1345                1350                1355                1360
Ile Arg Ser Gly Val Gly Leu Gly Thr Lys Gly Gly Cys Ala Ser Val
                1365                1370                1375    
Ile Val Ser Leu Thr Thr Gln Cys Pro Gln Asp Leu Thr Pro Tyr Ser
            1380                1385                1390        
Gly Lys Leu Met Ser Ala Leu Leu Ser Gly Leu Thr Asp Arg Asn Ser
        1395                1400                1405            
Val Ile Gln Lys Ser Cys Ala Phe Ala Met Gly His Leu Val Arg Thr
    1410                1415                1420                
Ser Arg Asp Ser Ser Thr Glu Lys Leu Leu Gln Lys Leu Asn Gly Trp
1425                1430                1435                1440
Tyr Met Glu Lys Glu Glu Pro Ile Tyr Lys Thr Ser Cys Ala Leu Thr
                1445                1450                1455    
Ile His Ala Ile Gly Arg Tyr Ser Pro Asp Val Leu Lys Asn His Ala
            1460                1465                1470        
Lys Glu Val Leu Pro Leu Ala Phe Leu Gly Met His Glu Ile Ala Asp
        1475                1480                1485            
Glu Glu Lys Ser Glu Lys Glu Glu Cys Asn Leu Trp Thr Glu Val Trp
    1490                1495                1500                
Gln Glu Asn Val Pro Gly Ser Phe Gly Gly Ile Arg Leu Tyr Leu Gln
1505                1510                1515                1520
Glu Leu Ile Thr Ile Thr Gln Lys Ala Leu Gln Ser Gln Ser Trp Lys
                1525                1530                1535    
Met Lys Ala Gln Gly Ala Ile Ala Met Ala Ser Ile Ala Lys Gln Thr
            1540                1545                1550        
Ser Ser Leu Val Pro Pro Tyr Leu Gly Met Ile Leu Thr Ala Leu Leu
        1555                1560                1565            
Gln Gly Leu Ala Gly Arg Thr Trp Ala Gly Lys Glu Glu Leu Leu Lys
    1570                1575                1580                
Ala Ile Ala Cys Val Val Thr Ala Cys Ser Ala Glu Leu Glu Lys Ser
1585                1590                1595                1600
Val Pro Asn Gln Pro Ser Thr Asn Glu Ile Leu Gln Ala Val Leu Lys
                1605                1610                1615    
Glu Cys Ser Lys Glu Asn Val Lys Tyr Lys Ile Val Ala Ile Ser Cys
            1620                1625                1630        
Ala Ala Asp Ile Leu Lys Ala Thr Lys Glu Asp Arg Phe Gln Glu Phe
        1635                1640                1645            
Ser Asn Ile Val Ile Pro Leu Ile Lys Lys Asn Ser Leu Glu Ser Ser
    1650                1655                1660                
Gly Val Arg Thr Thr Lys Asn Glu Glu Glu Asn Glu Lys Glu Lys Glu
1665                1670                1675                1680
Leu Gln Leu Glu Tyr Leu Leu Gly Ala Phe Glu Ser Leu Gly Lys Ala
                1685                1690                1695    
Trp Pro Arg Asn Ala Glu Thr Gln Arg Cys Tyr Arg Gln Glu Leu Cys
            1700                1705                1710        
Lys Leu Met Cys Glu Arg Leu Lys Leu Ser Thr Trp Lys Val Gln Leu
        1715                1720                1725            
Gly Val Leu Gln Ser Met Asn Ala Phe Phe Gln Gly Leu Met Leu Leu
    1730                1735                1740                
Glu Glu Glu His Ala Asp Pro Glu Ala Leu Ala Glu Ile Leu Leu Glu
1745                1750                1755                1760
Thr Cys Lys Ser Ile Thr Tyr Ser Leu Glu Asn Lys Thr Tyr Ser Ser
                1765                1770                1775    
Val Arg Thr Glu Ala Leu Ser Val Ile Glu Leu Leu Leu Lys Lys Leu
            1780                1785                1790        
Glu Glu Ser Lys Gln Trp Glu Cys Leu Thr Ser Glu Cys Arg Val Leu
        1795                1800                1805            
Leu Ile Glu Ser Leu Ala Thr Met Glu Pro Asp Ser Arg Pro Glu Leu
    1810                1815                1820                
Gln Glu Lys Ala Ala Leu Leu Lys Lys Thr Leu Glu Asn Leu Glu
1825                1830                1835                


<210> 6080
<211> 536
<212> PRT
<213> Homo sapiens

<400> 6080
Met Ser Pro Arg Val Val Ser Asn Ser Ser Val Leu Ala Ser Gln Ser
 1               5                  10                  15      
Val Gly Ile Thr Asn Val Arg Thr Val Phe Ser Asn Val Phe Asn Asn
            20                  25                  30          
Thr Thr Ala Phe Pro Ile Leu Arg Gly Ser Asn Cys His Lys Ile Thr
        35                  40                  45              
Ala Pro Gly Leu Gly Lys Gly Gln Leu Val Asn Leu Leu Pro Pro Glu
    50                  55                  60                  
Asn Leu Pro Trp Cys Gly Gly Ser Gln Gly Pro Arg Met Leu Arg Thr
65                  70                  75                  80  
Cys Tyr Val Leu Cys Ser Gln Ala Gly Pro Pro Ser Arg Gly Trp Gln
                85                  90                  95      
Ser Leu Ser Phe Asp Gly Gly Ala Phe His Leu Lys Gly Thr Gly Glu
            100                 105                 110         
Leu Thr Arg Ala Leu Leu Val Leu Arg Leu Cys Ala Trp Pro Pro Leu
        115                 120                 125             
Val Thr His Gly Leu Leu Leu Gln Ala Trp Ser Arg Arg Leu Leu Gly
    130                 135                 140                 
Ser Arg Leu Ser Gly Ala Phe Leu Arg Ala Ser Val Tyr Gly Gln Phe
145                 150                 155                 160 
Val Ala Gly Glu Thr Ala Glu Glu Val Lys Gly Cys Val Gln Gln Leu
                165                 170                 175     
Arg Thr Leu Ser Leu Arg Pro Leu Leu Ala Val Pro Thr Glu Glu Glu
            180                 185                 190         
Pro Asp Ser Ala Ala Lys Ser Gly Glu Ala Trp Tyr Glu Gly Asn Leu
        195                 200                 205             
Gly Ala Met Leu Arg Cys Val Asp Leu Ser Arg Gly Leu Leu Glu Pro
    210                 215                 220                 
Pro Ser Leu Ala Glu Ala Ser Leu Met Gln Leu Lys Val Thr Ala Leu
225                 230                 235                 240 
Thr Ser Thr Arg Leu Cys Lys Glu Leu Ala Ser Trp Val Arg Arg Pro
                245                 250                 255     
Gly Ala Ser Leu Glu Leu Ser Pro Glu Arg Leu Ala Glu Ala Met Asp
            260                 265                 270         
Ser Gly Gln Asn Leu Gln Val Ser Cys Leu Asn Ala Glu Gln Asn Gln
        275                 280                 285             
His Leu Arg Ala Ser Leu Ser Arg Leu His Arg Val Ala Gln Tyr Ala
    290                 295                 300                 
Arg Ala Gln His Val Arg Leu Leu Val Asp Ala Glu Tyr Thr Ser Leu
305                 310                 315                 320 
Asn Pro Ala Leu Ser Leu Leu Val Ala Ala Leu Ala Val Arg Trp Asn
                325                 330                 335     
Ser Pro Gly Glu Gly Gly Pro Trp Val Trp Asn Thr Tyr Gln Ala Cys
            340                 345                 350         
Leu Lys Asp Thr Phe Glu Arg Leu Gly Arg Asp Ala Glu Ala Ala His
        355                 360                 365             
Arg Ala Gly Leu Ala Phe Gly Val Lys Leu Val Arg Gly Ala Tyr Leu
    370                 375                 380                 
Asp Lys Glu Arg Ala Val Ala Gln Leu His Gly Met Glu Asp Pro Thr
385                 390                 395                 400 
Gln Pro Asp Tyr Glu Ala Thr Ser Gln Ser Tyr Ser Arg Cys Leu Glu
                405                 410                 415     
Leu Met Leu Thr His Val Ala Arg His Gly Pro Met Cys His Leu Met
            420                 425                 430         
Val Ala Ser His Asn Glu Glu Ser Val Arg Gln Ala Thr Lys Arg Met
        435                 440                 445             
Trp Glu Leu Gly Ile Pro Leu Asp Gly Thr Val Cys Phe Gly Gln Leu
    450                 455                 460                 
Leu Gly Met Cys Asp His Val Ser Leu Ala Leu Gly Gln Ala Gly Tyr
465                 470                 475                 480 
Val Val Tyr Lys Ser Ile Pro Tyr Gly Ser Leu Glu Glu Val Ile Pro
                485                 490                 495     
Tyr Leu Ile Arg Arg Ala Gln Glu Asn Arg Ser Val Leu Gln Gly Ala
            500                 505                 510         
Arg Arg Glu Gln Glu Leu Leu Ser Gln Glu Leu Trp Arg Arg Leu Leu
        515                 520                 525             
Pro Gly Cys Arg Arg Ile Pro His
    530                 535     


<210> 6081
<211> 701
<212> PRT
<213> Homo sapiens

<400> 6081
Cys Ile Thr Ser Ser Tyr Val Pro Leu Lys Pro Phe Glu Lys Asn Cys
 1               5                  10                  15      
Gln Asn Ile Thr Val Glu Val Glu Glu Phe Val Pro Glu Met Thr Lys
            20                  25                  30          
Tyr Cys Tyr Pro Phe Thr Ile Tyr Lys Asn His Leu Tyr Val Tyr Pro
        35                  40                  45              
Leu Gln Leu Lys Tyr Asp Ser Gln Lys Thr Phe Ala Lys Ala Arg Asn
    50                  55                  60                  
Ile Ala Val Cys Val Glu Phe Arg Asp Ser Asp Glu Ser Asp Ala Ser
65                  70                  75                  80  
Ala Leu Lys Cys Ile Tyr Gly Lys Pro Ala Gly Ser Val Phe Thr Thr
                85                  90                  95      
Asn Ala Tyr Ala Val Val Ser His His Asn Gln Asn Pro Glu Phe Tyr
            100                 105                 110         
Asp Glu Ile Lys Ile Glu Leu Pro Ile His Leu His Gln Lys His His
        115                 120                 125             
Leu Leu Phe Thr Phe Tyr His Val Ser Cys Glu Ile Asn Thr Lys Gly
    130                 135                 140                 
Thr Thr Lys Lys Gln Asp Thr Val Glu Thr Pro Val Gly Phe Ala Trp
145                 150                 155                 160 
Val Pro Leu Leu Lys Asp Gly Arg Ile Ile Thr Phe Glu Gln Gln Leu
                165                 170                 175     
Pro Val Ser Ala Asn Leu Pro Pro Gly Tyr Leu Asn Leu Asn Asp Ala
            180                 185                 190         
Glu Ser Arg Arg Gln Cys Asn Val Asp Ile Lys Trp Val Asp Gly Ala
        195                 200                 205             
Lys Pro Leu Leu Lys Ile Lys Ser His Leu Glu Ser Thr Ile Tyr Thr
    210                 215                 220                 
Gln Asp Leu His Val His Lys Phe Phe His His Cys Gln Leu Ile Gln
225                 230                 235                 240 
Ser Gly Ser Lys Glu Val Pro Gly Glu Leu Ile Lys Tyr Leu Lys Cys
                245                 250                 255     
Leu His Ala Met Glu Ile Gln Val Met Ile Gln Phe Leu Pro Val Ile
            260                 265                 270         
Leu Met Gln Leu Phe Arg Val Leu Thr Asn Met Thr His Glu Asp Asp
        275                 280                 285             
Val Pro Ile Asn Cys Thr Met Val Leu Leu His Ile Val Ser Lys Cys
    290                 295                 300                 
His Glu Glu Gly Leu Asp Ser Tyr Leu Arg Ser Phe Ile Lys Tyr Ser
305                 310                 315                 320 
Phe Arg Pro Glu Lys Pro Ser Ala Pro Gln Ala Gln Leu Ile His Glu
                325                 330                 335     
Thr Leu Ala Thr Thr Met Ile Ala Ile Leu Lys Gln Ser Ala Asp Phe
            340                 345                 350         
Leu Ser Ile Asn Lys Leu Leu Lys Tyr Ser Trp Phe Phe Phe Glu Ile
        355                 360                 365             
Ile Ala Lys Ser Met Ala Thr Tyr Leu Leu Glu Glu Asn Lys Ile Lys
    370                 375                 380                 
Leu Pro Arg Gly Gln Arg Phe Pro Glu Thr Tyr His His Val Leu His
385                 390                 395                 400 
Ser Leu Leu Leu Ala Ile Ile Pro His Val Thr Ile Arg Tyr Ala Glu
                405                 410                 415     
Ile Pro Asp Glu Ser Arg Asn Val Asn Tyr Ser Leu Ala Ser Phe Leu
            420                 425                 430         
Lys Arg Cys Leu Thr Leu Met Asp Arg Gly Phe Ile Phe Asn Leu Ile
        435                 440                 445             
Asn Asp Tyr Ile Ser Gly Phe Ser Pro Lys Asp Pro Lys Val Leu Ala
    450                 455                 460                 
Glu Tyr Lys Phe Glu Phe Leu Gln Thr Ile Cys Asn His Glu His Tyr
465                 470                 475                 480 
Ile Pro Leu Asn Leu Pro Met Ala Phe Ala Lys Pro Lys Leu Gln Arg
                485                 490                 495     
Val Gln Asp Ser Asn Leu Glu Tyr Ser Leu Ser Asp Glu Tyr Cys Lys
            500                 505                 510         
His His Phe Leu Val Gly Leu Leu Leu Arg Glu Thr Ser Ile Ala Leu
        515                 520                 525             
Gln Asp Asn Tyr Glu Ile Arg Tyr Thr Ala Ile Ser Val Ile Lys Asn
    530                 535                 540                 
Leu Leu Ile Lys His Ala Phe Asp Thr Arg Tyr Gln His Lys Asn Gln
545                 550                 555                 560 
Gln Ala Lys Ile Ala Gln Leu Tyr Leu Pro Phe Val Gly Leu Leu Leu
                565                 570                 575     
Glu Asn Ile Gln Arg Leu Ala Gly Arg Asp Thr Leu Tyr Ser Cys Ala
            580                 585                 590         
Ala Met Pro Asn Ser Leu Met Gly Leu Phe Lys Met Asp Met Glu Leu
        595                 600                 605             
Arg Glu Lys Ile Gln Glu Val Pro Ser Ser Gln Lys Glu Gln Gln Asp
    610                 615                 620                 
Phe Gln Ile Arg Ala Thr Leu Val Lys Ile His Asp Tyr Phe Lys Ile
625                 630                 635                 640 
Leu Pro Leu Lys His Met Ala Tyr Glu Asn Glu Thr Gln Tyr Ser Trp
                645                 650                 655     
Leu Tyr Leu Cys Glu Asp Ser Lys Thr Arg Gln Ser Ser Thr Arg Ser
            660                 665                 670         
Ser Val Ser Gln Tyr Asn Arg Leu Asp Gln Tyr Glu Ile Arg Ser Leu
        675                 680                 685             
Leu Met Cys Tyr Leu Tyr Ile Val Lys Met Ile Ser Glu
    690                 695                 700     


<210> 6082
<211> 2073
<212> PRT
<213> Homo sapiens

<400> 6082
Met Ala Glu Val Arg Lys Phe Thr Lys Arg Leu Ser Lys Pro Gly Thr
 1               5                  10                  15      
Ala Ala Glu Leu Arg Gln Ser Val Ser Glu Ala Val Arg Gly Ser Val
            20                  25                  30          
Val Leu Glu Lys Ala Lys Val Val Glu Pro Leu Asp Tyr Glu Asn Val
        35                  40                  45              
Ile Ala Gln Arg Lys Thr Gln Ile Tyr Ser Asp Pro Leu Arg Asp Leu
    50                  55                  60                  
Leu Met Phe Pro Met Glu Asp Ile Ser Ile Ser Val Ile Gly Arg Gln
65                  70                  75                  80  
Arg Arg Thr Val Gln Ser Thr Val Pro Glu Asp Ala Glu Lys Arg Ala
                85                  90                  95      
Gln Ser Leu Phe Val Lys Glu Cys Ile Lys Thr Tyr Ser Thr Asp Trp
            100                 105                 110         
His Val Val Asn Tyr Lys Tyr Glu Asp Phe Ser Gly Asp Phe Arg Met
        115                 120                 125             
Leu Pro Cys Lys Ser Leu Arg Pro Glu Lys Ile Pro Asn His Val Phe
    130                 135                 140                 
Glu Ile Asp Glu Asp Cys Glu Lys Asp Glu Asp Ser Ser Ser Leu Cys
145                 150                 155                 160 
Ser Gln Lys Gly Gly Val Ile Lys Gln Gly Trp Leu His Lys Ala Asn
                165                 170                 175     
Val Asn Ser Thr Ile Thr Val Thr Met Lys Val Phe Lys Arg Arg Tyr
            180                 185                 190         
Phe Tyr Leu Thr Gln Leu Pro Asp Gly Ser Tyr Ile Leu Asn Ser Tyr
        195                 200                 205             
Lys Asp Glu Lys Asn Ser Lys Glu Ser Lys Gly Cys Ile Tyr Leu Asp
    210                 215                 220                 
Ala Cys Ile Asp Val Val Gln Cys Pro Lys Met Arg Arg His Ala Phe
225                 230                 235                 240 
Glu Leu Lys Met Leu Asp Lys Tyr Ser His Tyr Leu Ala Ala Glu Thr
                245                 250                 255     
Glu Gln Glu Met Glu Glu Trp Leu Ile Thr Leu Lys Lys Ile Ile Gln
            260                 265                 270         
Ile Asn Thr Asp Ser Leu Val Gln Glu Lys Lys Glu Thr Val Glu Thr
        275                 280                 285             
Ala Gln Asp Asp Glu Thr Ser Ser Gln Gly Lys Ala Glu Asn Ile Met
    290                 295                 300                 
Ala Ser Leu Glu Arg Ser Met His Pro Glu Leu Met Lys Tyr Gly Arg
305                 310                 315                 320 
Glu Thr Glu Gln Leu Asn Lys Leu Ser Arg Gly Asp Gly Arg Gln Asn
                325                 330                 335     
Leu Phe Ser Phe Asp Ser Glu Val Gln Arg Leu Asp Phe Ser Gly Ile
            340                 345                 350         
Glu Pro Asp Ile Lys Pro Phe Glu Glu Lys Cys Asn Lys Arg Phe Leu
        355                 360                 365             
Val Asn Cys His Asp Leu Thr Phe Asn Ile Leu Gly Gln Ile Gly Asp
    370                 375                 380                 
Asn Ala Lys Gly Pro Pro Thr Asn Val Glu Pro Phe Phe Ile Asn Leu
385                 390                 395                 400 
Ala Leu Phe Asp Val Lys Asn Asn Cys Lys Ile Ser Ala Asp Phe His
                405                 410                 415     
Val Asp Leu Asn Pro Pro Ser Val Arg Glu Met Leu Trp Gly Ser Ser
            420                 425                 430         
Thr Gln Leu Ala Ser Asp Gly Ser Pro Lys Gly Ser Ser Pro Glu Ser
        435                 440                 445             
Tyr Ile His Gly Ile Ala Glu Ser Gln Leu Arg Tyr Ile Gln Gln Gly
    450                 455                 460                 
Ile Phe Ser Val Thr Asn Pro His Pro Glu Ile Phe Leu Val Ala Arg
465                 470                 475                 480 
Ile Glu Lys Val Leu Gln Gly Asn Ile Thr His Cys Ala Glu Pro Tyr
                485                 490                 495     
Ile Lys Asn Ser Asp Pro Val Lys Thr Ala Gln Lys Val His Arg Thr
            500                 505                 510         
Ala Lys Gln Val Cys Ser Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala
        515                 520                 525             
Trp Ala Ala Arg Pro Ile Phe Lys Asp Thr Gln Gly Ser Leu Asp Leu
    530                 535                 540                 
Asp Gly Arg Phe Ser Pro Leu Tyr Lys Gln Asp Ser Ser Lys Leu Ser
545                 550                 555                 560 
Ser Glu Asp Ile Leu Lys Leu Leu Ser Glu Tyr Lys Lys Pro Glu Lys
                565                 570                 575     
Thr Lys Leu Gln Ile Ile Pro Gly Gln Leu Asn Ile Thr Val Glu Cys
            580                 585                 590         
Val Pro Val Asp Leu Ser Asn Cys Ile Thr Ser Ser Tyr Val Pro Leu
        595                 600                 605             
Lys Pro Phe Glu Lys Asn Cys Gln Asn Ile Thr Val Glu Val Glu Glu
    610                 615                 620                 
Phe Val Pro Glu Met Thr Lys Tyr Cys Tyr Pro Phe Thr Ile Tyr Lys
625                 630                 635                 640 
Asn His Leu Tyr Val Tyr Pro Leu Gln Leu Lys Tyr Asp Ser Gln Lys
                645                 650                 655     
Thr Phe Ala Lys Ala Arg Asn Ile Ala Val Cys Val Glu Phe Arg Asp
            660                 665                 670         
Ser Asp Glu Ser Asp Ala Ser Ala Leu Lys Cys Ile Tyr Gly Lys Pro
        675                 680                 685             
Ala Gly Ser Val Phe Thr Thr Asn Ala Tyr Ala Val Val Ser His His
    690                 695                 700                 
Asn Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Ile
705                 710                 715                 720 
His Leu His Gln Lys His Arg Leu Leu Phe Thr Phe Tyr His Val Ser
                725                 730                 735     
Cys Glu Ile Asn Thr Lys Gly Thr Thr Lys Lys Gln Asp Thr Val Glu
            740                 745                 750         
Thr Pro Val Gly Phe Ala Trp Val Pro Leu Leu Lys Asp Gly Arg Ile
        755                 760                 765             
Ile Thr Phe Glu Gln Gln Leu Pro Val Ser Ala Asn Leu Pro Pro Gly
    770                 775                 780                 
Tyr Leu Asn Leu Asn Asp Ala Glu Ser Arg Arg Gln Cys Asn Val Asp
785                 790                 795                 800 
Ile Lys Trp Val Asp Gly Ala Lys Pro Leu Leu Lys Ile Lys Ser His
                805                 810                 815     
Leu Glu Ser Thr Ile Tyr Thr Gln Asp Leu His Val His Lys Phe Phe
            820                 825                 830         
His His Cys Gln Leu Ile Gln Ser Gly Ser Lys Glu Val Pro Gly Glu
        835                 840                 845             
Leu Ile Lys Tyr Leu Lys Cys Leu His Ala Met Glu Ile Gln Val Met
    850                 855                 860                 
Ile Gln Phe Leu Pro Val Ile Leu Met Gln Leu Phe Arg Val Leu Thr
865                 870                 875                 880 
Asn Met Thr His Glu Asp Asp Val Pro Ile Asn Cys Thr Met Val Leu
                885                 890                 895     
Leu His Ile Val Ser Lys Cys His Glu Glu Gly Leu Asp Ser Tyr Leu
            900                 905                 910         
Arg Ser Phe Ile Lys Tyr Ser Phe Arg Pro Glu Lys Pro Ser Ala Pro
        915                 920                 925             
Gln Ala Gln Leu Ile His Glu Thr Leu Ala Thr Thr Met Ile Ala Ile
    930                 935                 940                 
Leu Lys Gln Ser Ala Asp Phe Leu Ser Ile Asn Lys Leu Leu Lys Tyr
945                 950                 955                 960 
Ser Trp Phe Phe Phe Glu Ile Ile Ala Lys Ser Met Ala Thr Tyr Leu
                965                 970                 975     
Leu Glu Glu Asn Lys Ile Lys Leu Pro Arg Gly Gln Arg Phe Pro Glu
            980                 985                 990         
Thr Tyr His His Val Leu His Ser Leu Leu Leu Ala Ile Ile Pro His
        995                 1000                1005            
Val Thr Ile Arg Tyr Ala Glu Ile Pro Asp Glu Ser Arg Asn Val Asn
    1010                1015                1020                
Tyr Ser Leu Ala Ser Phe Leu Lys Arg Cys Leu Thr Leu Met Asp Arg
1025                1030                1035                1040
Gly Phe Ile Phe Asn Leu Ile Asn Asp Tyr Ile Ser Gly Phe Ser Pro
                1045                1050                1055    
Lys Asp Pro Lys Val Leu Ala Glu Tyr Lys Phe Glu Phe Leu Gln Thr
            1060                1065                1070        
Ile Cys Asn His Glu His Tyr Ile Pro Leu Asn Leu Pro Met Ala Phe
        1075                1080                1085            
Ala Lys Pro Lys Leu Gln Arg Val Gln Asp Ser Asn Leu Glu Tyr Ser
    1090                1095                1100                
Leu Ser Asp Glu Tyr Cys Lys His His Phe Leu Val Gly Leu Leu Leu
1105                1110                1115                1120
Arg Glu Thr Ser Ile Ala Leu Gln Asp Asn Tyr Glu Ile Arg Tyr Thr
                1125                1130                1135    
Ala Ile Ser Val Ile Lys Asn Leu Leu Ile Lys His Ala Phe Asp Thr
            1140                1145                1150        
Arg Tyr Gln His Lys Asn Gln Gln Ala Lys Ile Ala Gln Leu Tyr Leu
        1155                1160                1165            
Pro Phe Val Gly Leu Leu Leu Glu Asn Ile Gln Arg Leu Ala Gly Arg
    1170                1175                1180                
Asp Thr Leu Tyr Ser Cys Ala Ala Met Pro Asn Ser Ala Ser Arg Asp
1185                1190                1195                1200
Glu Phe Pro Cys Gly Phe Thr Ser Pro Ala Asn Arg Gly Ser Leu Ser
                1205                1210                1215    
Thr Asp Lys Asp Thr Ala Tyr Gly Ser Phe Gln Asn Gly His Gly Ile
            1220                1225                1230        
Lys Arg Glu Asp Ser Arg Gly Ser Leu Ile Pro Glu Gly Ala Thr Gly
        1235                1240                1245            
Phe Pro Asp Gln Gly Asn Thr Gly Glu Asn Thr Arg Gln Ser Ser Thr
    1250                1255                1260                
Arg Ser Ser Val Ser Gln Tyr Asn Arg Leu Asp Gln Tyr Glu Ile Arg
1265                1270                1275                1280
Ser Leu Leu Met Cys Tyr Leu Tyr Ile Val Lys Met Ile Ser Glu Asp
                1285                1290                1295    
Thr Leu Leu Thr Tyr Trp Asn Lys Val Ser Pro Gln Glu Leu Ile Asn
            1300                1305                1310        
Ile Leu Ile Leu Leu Glu Val Cys Leu Phe His Phe Arg Tyr Met Gly
        1315                1320                1325            
Lys Arg Asn Ile Ala Arg Val His Asp Ala Trp Leu Ser Lys His Phe
    1330                1335                1340                
Gly Ile Asp Arg Lys Ser Gln Thr Met Pro Ala Leu Arg Asn Arg Ser
1345                1350                1355                1360
Gly Val Met Gln Ala Arg Leu Gln His Leu Ser Ser Leu Glu Ser Ser
                1365                1370                1375    
Phe Thr Leu Asn His Ser Ser Thr Thr Thr Glu Ala Asp Ile Phe His
            1380                1385                1390        
Gln Ala Leu Leu Glu Gly Asn Thr Ala Thr Glu Val Ser Leu Thr Val
        1395                1400                1405            
Leu Asp Thr Ile Ser Phe Phe Thr Gln Cys Phe Lys Thr Gln Leu Leu
    1410                1415                1420                
Asn Asn Asp Gly His Asn Pro Leu Met Lys Lys Val Phe Asp Ile His
1425                1430                1435                1440
Leu Ala Phe Leu Lys Asn Gly Gln Ser Glu Val Ser Leu Lys His Val
                1445                1450                1455    
Phe Ala Ser Leu Arg Ala Phe Ile Ser Lys Phe Pro Ser Ala Phe Phe
            1460                1465                1470        
Lys Gly Arg Val Asn Met Cys Ala Ala Phe Cys Tyr Glu Val Leu Lys
        1475                1480                1485            
Cys Cys Thr Ser Lys Ile Ser Ser Thr Arg Asn Glu Ala Ser Ala Leu
    1490                1495                1500                
Leu Tyr Leu Leu Met Arg Asn Asn Phe Glu Tyr Thr Lys Arg Lys Thr
1505                1510                1515                1520
Phe Leu Arg Thr His Leu Gln Ile Ile Ile Ala Val Ser Gln Leu Ile
                1525                1530                1535    
Ala Asp Val Ala Leu Ser Gly Gly Ser Arg Phe Gln Glu Ser Leu Phe
            1540                1545                1550        
Ile Ile Asn Asn Phe Ala Asn Ser Asp Arg Pro Met Lys Ala Thr Ala
        1555                1560                1565            
Phe Pro Ala Glu Val Lys Asp Leu Thr Lys Arg Ile Arg Thr Val Leu
    1570                1575                1580                
Met Ala Thr Ala Gln Met Lys Glu His Glu Lys Asp Pro Glu Met Leu
1585                1590                1595                1600
Ile Asp Leu Gln Tyr Ser Leu Ala Lys Ser Tyr Ala Ser Thr Pro Glu
                1605                1610                1615    
Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Lys Ile His Val Lys Asn
            1620                1625                1630        
Gly Asp Phe Ser Glu Ala Ala Met Cys Tyr Val His Val Ala Ala Leu
        1635                1640                1645            
Val Ala Glu Phe Leu His Arg Lys Lys Leu Phe Pro Asn Gly Cys Ser
    1650                1655                1660                
Ala Phe Lys Lys Ile Thr Pro Asn Ile Asp Glu Glu Gly Ala Met Lys
1665                1670                1675                1680
Glu Asp Ala Gly Met Met Asp Val His Tyr Ser Glu Glu Val Leu Leu
                1685                1690                1695    
Glu Leu Leu Glu Gln Cys Val Asp Gly Leu Trp Lys Ala Glu Arg Tyr
            1700                1705                1710        
Glu Ile Ile Ser Glu Ile Ser Lys Leu Ile Val Pro Ile Tyr Glu Lys
        1715                1720                1725            
Arg Arg Glu Phe Glu Lys Leu Thr Gln Val Tyr Arg Thr Leu His Gly
    1730                1735                1740                
Ala Tyr Thr Lys Ile Leu Glu Val Met His Thr Lys Lys Arg Leu Leu
1745                1750                1755                1760
Gly Thr Phe Phe Arg Val Ala Phe Tyr Gly Gln Ser Phe Phe Glu Glu
                1765                1770                1775    
Glu Asp Gly Lys Glu Tyr Ile Tyr Lys Glu Pro Lys Leu Thr Gly Leu
            1780                1785                1790        
Ser Glu Ile Ser Leu Arg Leu Val Lys Leu Tyr Gly Glu Lys Phe Gly
        1795                1800                1805            
Thr Glu Asn Val Lys Ile Ile Gln Asp Ser Asp Lys Val Asn Ala Lys
    1810                1815                1820                
Glu Leu Asp Pro Lys Tyr Ala His Ile Gln Val Thr Tyr Val Lys Pro
1825                1830                1835                1840
Tyr Phe Asp Asp Lys Glu Leu Thr Glu Arg Lys Thr Glu Phe Glu Arg
                1845                1850                1855    
Asn His Asn Ile Ser Arg Phe Val Phe Glu Ala Pro Tyr Thr Leu Ser
            1860                1865                1870        
Gly Lys Lys Gln Gly Cys Ile Glu Glu Gln Cys Lys Arg Arg Thr Ile
        1875                1880                1885            
Leu Thr Thr Ser Asn Ser Phe Pro Tyr Val Lys Lys Arg Ile Pro Ile
    1890                1895                1900                
Asn Cys Glu Gln Gln Ile Asn Leu Lys Pro Ile Asp Val Ala Thr Asp
1905                1910                1915                1920
Glu Ile Lys Asp Lys Thr Ala Glu Leu Gln Lys Leu Cys Ser Ser Thr
                1925                1930                1935    
Asp Val Asp Met Ile Gln Leu Gln Leu Lys Leu Gln Gly Cys Val Ser
            1940                1945                1950        
Val Gln Val Asn Ala Gly Pro Leu Ala Tyr Ala Arg Ala Phe Leu Asn
        1955                1960                1965            
Asp Ser Gln Ala Ser Lys Tyr Pro Pro Lys Lys Val Ser Glu Leu Lys
    1970                1975                1980                
Asp Met Phe Arg Lys Phe Ile Gln Ala Cys Ser Ile Ala Leu Glu Leu
1985                1990                1995                2000
Asn Glu Arg Leu Ile Lys Glu Asp Gln Val Glu Tyr His Glu Gly Leu
                2005                2010                2015    
Lys Ser Asn Phe Arg Asp Met Val Lys Glu Leu Ser Asp Ile Ile His
            2020                2025                2030        
Glu Gln Ile Leu Gln Glu Asp Thr Met His Ser Pro Trp Met Ser Asn
        2035                2040                2045            
Thr Leu His Val Phe Cys Ala Ile Ser Gly Thr Ser Ser Asp Arg Gly
    2050                2055                2060                
Tyr Gly Ser Pro Arg Tyr Ala Glu Val
2065                2070            


<210> 6083
<211> 477
<212> PRT
<213> Homo sapiens

<400> 6083
Arg Leu Val Asn Ser Ala Ala Gln Thr Cys Ser Gly Leu Arg Val Arg
 1               5                  10                  15      
Ala Gln Arg Arg Ala Gly Gly Leu Ala Arg Ala Leu Pro Arg Pro Ala
            20                  25                  30          
Cys Val Pro Arg Pro Ala Pro Pro Pro Pro Ser Arg Ser Pro Pro Arg
        35                  40                  45              
Ala Pro Gly Ser Ala Gly Pro Met Pro Ala Gly Arg Arg Gly Pro Ala
    50                  55                  60                  
Ala Gln Ser Ala Arg Arg Pro Pro Pro Leu Leu Pro Leu Leu Leu Leu
65                  70                  75                  80  
Leu Cys Val Leu Gly Ala Pro Arg Ala Gly Ser Gly Ala His Thr Ala
                85                  90                  95      
Val Ile Ser Pro Gln Asp Pro Thr Leu Leu Ile Gly Ser Ser Leu Leu
            100                 105                 110         
Ala Thr Cys Ser Val His Gly Asp Pro Pro Gly Ala Thr Ala Glu Gly
        115                 120                 125             
Leu Tyr Trp Thr Leu Asn Gly Arg Arg Leu Pro Pro Glu Leu Ser Arg
    130                 135                 140                 
Val Leu Asn Ala Ser Thr Leu Ala Leu Ala Leu Ala Asn Leu Asn Gly
145                 150                 155                 160 
Ser Arg Gln Arg Ser Gly Asp Asn Leu Val Cys His Ala Arg Asp Gly
                165                 170                 175     
Ser Ile Leu Ala Gly Ser Cys Leu Tyr Val Gly Leu Pro Pro Glu Lys
            180                 185                 190         
Pro Val Asn Ile Ser Cys Trp Ser Lys Asn Met Lys Asp Leu Thr Cys
        195                 200                 205             
Arg Trp Thr Pro Gly Ala His Gly Glu Thr Phe Leu His Thr Asn Tyr
    210                 215                 220                 
Ser Leu Lys Tyr Lys Leu Arg Trp Tyr Gly Gln Asp Asn Thr Cys Glu
225                 230                 235                 240 
Glu Tyr His Thr Val Gly Pro His Ser Cys His Ile Pro Lys Asp Leu
                245                 250                 255     
Ala Leu Phe Thr Pro Tyr Glu Ile Trp Val Glu Ala Thr Asn Arg Leu
            260                 265                 270         
Gly Ser Ala Arg Ser Asp Val Leu Thr Leu Asp Ile Leu Asp Val Val
        275                 280                 285             
Thr Thr Asp Pro Pro Pro Asp Val His Val Ser Arg Val Gly Gly Leu
    290                 295                 300                 
Glu Asp Gln Leu Ser Val Arg Trp Val Ser Pro Pro Ala Leu Lys Asp
305                 310                 315                 320 
Phe Leu Phe Gln Ala Lys Tyr Gln Ile Arg Tyr Arg Val Glu Asp Ser
                325                 330                 335     
Val Asp Trp Lys Val Val Asp Asp Val Ser Asn Gln Thr Ser Cys Arg
            340                 345                 350         
Leu Ala Gly Leu Lys Pro Gly Thr Val Tyr Phe Val Gln Val Arg Cys
        355                 360                 365             
Asn Pro Phe Gly Ile Tyr Gly Ser Lys Lys Ala Gly Ile Trp Ser Glu
    370                 375                 380                 
Trp Ser His Pro Thr Ala Ala Ser Thr Pro Arg Ser Glu Arg Pro Gly
385                 390                 395                 400 
Pro Gly Gly Gly Ala Cys Glu Pro Arg Gly Gly Glu Pro Ser Ser Gly
                405                 410                 415     
Pro Val Arg Arg Glu Leu Lys Gln Phe Leu Gly Trp Leu Lys Lys His
            420                 425                 430         
Ala Tyr Cys Ser Asn Leu Ser Phe Arg Leu Tyr Asp Gln Trp Arg Ala
        435                 440                 445             
Trp Met Gln Lys Ser His Lys Thr Arg Asn Gln Asp Glu Gly Ile Leu
    450                 455                 460                 
Pro Ser Gly Arg Arg Gly Thr Ala Arg Gly Pro Ala Arg
465                 470                 475         


<210> 6084
<211> 261
<212> PRT
<213> Homo sapiens

<400> 6084
Met Gly Cys Ile Gln Ser Ile Thr Cys Lys Ala Arg Ile Arg Arg Glu
 1               5                  10                  15      
Asn Ile Val Val Tyr Asp Val Cys Ala Thr Ile Asp Gln Cys Pro Thr
            20                  25                  30          
Arg Ile Glu Glu Thr Ser Pro Ile Val Leu Arg Tyr Lys Thr Pro Tyr
        35                  40                  45              
Phe Lys Ala Ser Ala Arg Val Val Met Pro Pro Ile Pro Arg His Glu
    50                  55                  60                  
Thr Trp Val Val Gly Trp Ile Gln Ala Cys Asn Gln Met Glu Phe Phe
65                  70                  75                  80  
Asn Thr Tyr Ser Asp Leu Gly Met Ser Ser Trp Glu Leu Pro Asp Leu
                85                  90                  95      
Arg Glu Gly Arg Val Lys Ala Ile Ser Asp Ser Asp Gly Val Ser Tyr
            100                 105                 110         
Pro Trp Tyr Gly Asn Thr Thr Glu Thr Val Thr Leu Val Gly Pro Thr
        115                 120                 125             
Asn Lys Ile Ser Arg Phe Ser Val Ser Met Asn Asp Asn Phe Tyr Pro
    130                 135                 140                 
Ser Val Thr Trp Ala Val Pro Val Ser Asp Ser Asn Val Pro Leu Leu
145                 150                 155                 160 
Thr Arg Ile Lys Arg Asp Gln Ser Phe Thr Thr Trp Leu Val Ala Met
                165                 170                 175     
Asn Thr Thr Thr Lys Glu Lys Ile Ile Leu Gln Thr Ile Lys Trp Arg
            180                 185                 190         
Met Arg Val Asp Ile Glu Val Asp Pro Leu Gln Leu Leu Gly Gln Arg
        195                 200                 205             
Ala Arg Leu Val Gly Arg Thr Gln Gln Glu Gln Pro Arg Ile Leu Ser
    210                 215                 220                 
Arg Met Glu Pro Ile Pro Pro Asn Ala Leu Val Lys Pro Asn Ala Asn
225                 230                 235                 240 
Asp Ala Gln Val Leu Met Trp Arg Pro Lys Arg Gly Pro Pro Leu Val
                245                 250                 255     
Val Ile Pro Pro Lys
            260     


<210> 6085
<211> 660
<212> PRT
<213> Homo sapiens

<400> 6085
Met Ser His Val Val Val Lys Asn Asp Pro Glu Leu Asp Gln Gln Leu
 1               5                  10                  15      
Ala Asn Leu Asp Leu Asn Ser Glu Lys Gln Ser Gly Gly Ala Ser Thr
            20                  25                  30          
Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala
        35                  40                  45              
Ser Lys Gly Phe His Asp Lys Asp Ser Ser Gly Trp Ser Cys Ser Lys
    50                  55                  60                  
Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Asp Ser Arg Gly Lys
65                  70                  75                  80  
Pro Gly Tyr Phe Ser Glu Arg Gly Ser Gly Ser Arg Gly Arg Phe Asp
                85                  90                  95      
Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Asn Arg Glu Arg Pro
            100                 105                 110         
Gly Phe Gly Arg Phe Glu Arg Ser Gly His Ser Arg Trp Cys Asp Lys
        115                 120                 125             
Ser Val Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu Arg Leu
    130                 135                 140                 
Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe Glu Lys
145                 150                 155                 160 
Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Ser Asn Cys Pro Pro His
                165                 170                 175     
Ile Glu Asn Phe Ser Asp Ile Asp Met Gly Glu Ile Ile Met Gly Asn
            180                 185                 190         
Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys His Ala
        195                 200                 205             
Ile Pro Ile Ile Lys Gly Lys Arg Asp Leu Met Ala Cys Ala Gln Thr
    210                 215                 220                 
Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Gln Ile
225                 230                 235                 240 
Tyr Thr Asp Gly Pro Gly Glu Ala Leu Lys Ala Val Lys Glu Asn Gly
                245                 250                 255     
Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu Ala Pro
            260                 265                 270         
Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys Phe Ser
        275                 280                 285             
Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala Asp Ile
    290                 295                 300                 
Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu Val Ala
305                 310                 315                 320 
Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile Gly Leu
                325                 330                 335     
Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp
            340                 345                 350         
Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp Thr Met
        355                 360                 365             
Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr Phe Pro
    370                 375                 380                 
Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr Ile Phe
385                 390                 395                 400 
Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr Gln Lys
                405                 410                 415     
Val Val Trp Val Glu Asp Leu Asp Lys Arg Ser Phe Leu Leu Asp Ile
            420                 425                 430         
Leu Gly Ala Thr Gly Ser Asp Ser Leu Thr Leu Val Phe Val Glu Thr
        435                 440                 445             
Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu Gly Tyr
    450                 455                 460                 
Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg Glu Glu
465                 470                 475                 480 
Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val Ala Thr
                485                 490                 495     
Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Arg His Val Ile
            500                 505                 510         
Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg Ile Gly
        515                 520                 525             
Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe Asn
    530                 535                 540                 
Glu Lys Asn Met Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu Val Glu
545                 550                 555                 560 
Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr Glu His
                565                 570                 575     
His Tyr Lys Gly Gly Ser Arg Gly Arg Ser Lys Ser Asn Arg Phe Ser
            580                 585                 590         
Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ser Ser Ser
        595                 600                 605             
Ser Gly Phe Gly Ala Ser Arg Gly Ser Ser Ser Arg Ser Gly Gly Gly
    610                 615                 620                 
Gly Tyr Gly Asn Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly Phe
625                 630                 635                 640 
Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val Asp
                645                 650                 655     
Trp Trp Gly Asn
            660 


<210> 6086
<211> 660
<212> PRT
<213> Homo sapiens

<400> 6086
Met Ser His Val Val Val Lys Asn Asp Pro Glu Leu Asp Gln Gln Leu
 1               5                  10                  15      
Ala Asn Leu Asp Leu Asn Ser Glu Lys Gln Ser Gly Gly Ala Ser Thr
            20                  25                  30          
Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Lys Glu Ala
        35                  40                  45              
Ser Lys Gly Phe His Asp Lys Asp Ser Ser Gly Trp Ser Cys Ser Lys
    50                  55                  60                  
Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Asp Ser Arg Gly Lys
65                  70                  75                  80  
Pro Gly Tyr Phe Ser Glu Arg Gly Ser Gly Ser Arg Gly Arg Phe Asp
                85                  90                  95      
Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Asn Arg Glu Arg Pro
            100                 105                 110         
Gly Phe Gly Arg Phe Glu Arg Ser Gly His Ser Arg Trp Cys Asp Lys
        115                 120                 125             
Ser Val Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu Arg Leu
    130                 135                 140                 
Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe Glu Lys
145                 150                 155                 160 
Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Ser Asn Cys Pro Pro His
                165                 170                 175     
Ile Glu Asn Phe Ser Asp Ile Asp Met Gly Glu Ile Ile Met Gly Asn
            180                 185                 190         
Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys His Ala
        195                 200                 205             
Ile Pro Ile Ile Lys Gly Lys Arg Asp Leu Val Ala Cys Ala Gln Thr
    210                 215                 220                 
Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Gln Ile
225                 230                 235                 240 
Tyr Thr Asp Gly Pro Gly Glu Ala Leu Lys Ala Val Lys Glu Asn Gly
                245                 250                 255     
Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu Ala Pro
            260                 265                 270         
Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys Phe Ser
        275                 280                 285             
Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala Asp Ile
    290                 295                 300                 
Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu Val Ala
305                 310                 315                 320 
Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile Gly Leu
                325                 330                 335     
Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp
            340                 345                 350         
Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp Thr Met
        355                 360                 365             
Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr Phe Pro
    370                 375                 380                 
Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr Ile Phe
385                 390                 395                 400 
Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr Gln Lys
                405                 410                 415     
Val Val Trp Val Glu Asp Leu Asp Lys Arg Ser Phe Leu Leu Asp Ile
            420                 425                 430         
Leu Gly Ala Thr Gly Ser Asp Ser Leu Thr Leu Val Phe Val Glu Thr
        435                 440                 445             
Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu Gly Tyr
    450                 455                 460                 
Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg Glu Glu
465                 470                 475                 480 
Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val Ala Thr
                485                 490                 495     
Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Arg His Val Ile
            500                 505                 510         
Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg Ile Gly
        515                 520                 525             
Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe Asn
    530                 535                 540                 
Glu Lys Asn Met Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu Val Glu
545                 550                 555                 560 
Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr Glu His
                565                 570                 575     
His Tyr Lys Gly Gly Ser Arg Gly Arg Ser Lys Ser Asn Arg Phe Ser
            580                 585                 590         
Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ser Ser Ser
        595                 600                 605             
Ser Gly Phe Gly Ala Ser Arg Gly Ser Ser Ser Arg Ser Gly Gly Gly
    610                 615                 620                 
Gly Tyr Gly Asp Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly Phe
625                 630                 635                 640 
Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val Asp
                645                 650                 655     
Trp Trp Gly Asn
            660 


<210> 6087
<211> 1794
<212> PRT
<213> Homo sapiens

<400> 6087
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Gly Leu Ala Val Met Glu Val Ala Pro Ser Phe Ser
        435                 440                 445             
Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly Gln Asp Phe Val Leu
    450                 455                 460                 
Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg Ile Thr Trp Leu Leu
465                 470                 475                 480 
Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr Cys Glu Ala Gly Val
                485                 490                 495     
Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu Asp His Gly Thr Tyr
            500                 505                 510         
Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val Ser Cys Ser Ala Trp
        515                 520                 525             
Val Thr Val His Glu Lys Lys Ser Ser Arg Lys Ser Glu Tyr Leu Leu
    530                 535                 540                 
Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile Phe Leu Gln Gly Leu
545                 550                 555                 560 
Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val Thr Met Thr Val Gln
                565                 570                 575     
Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp Leu His Asn Gly Asn
            580                 585                 590         
Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu Gln Arg Gly Thr Gln
        595                 600                 605             
His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu Asp Thr Gly Thr Tyr
    610                 615                 620                 
Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val Arg Thr Gln Ala Val
625                 630                 635                 640 
Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln Pro Trp Phe Ile Ser
                645                 650                 655     
Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln Ser Val Leu Ile Ser
            660                 665                 670         
Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val His Trp Leu Arg Asp
        675                 680                 685             
Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe Glu Val Leu Gln Asn
    690                 695                 700                 
Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val Gln Pro Trp His Ala
705                 710                 715                 720 
Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val Gly Glu Cys Ser Cys
                725                 730                 735     
Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala Arg Ala Leu Pro Arg
            740                 745                 750         
Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys Gly Gly Gly Val Gly
        755                 760                 765             
Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser Leu Arg Pro Gly Trp
    770                 775                 780                 
Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu Asp Gly Glu Asp Val
785                 790                 795                 800 
Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg Gln His Thr Glu Glu
                805                 810                 815     
Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp Phe Arg Asp Leu Leu
            820                 825                 830         
Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu Asp Asp Leu Lys Glu
        835                 840                 845             
Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn Leu Gln Arg Gln Val
    850                 855                 860                 
Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys Val His Ser Pro Gln
865                 870                 875                 880 
Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys Gly Thr Ser Lys Thr
                885                 890                 895     
Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro Ala Thr Pro Asp Phe
            900                 905                 910         
Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro Ala Glu Asn Gly Ser
        915                 920                 925             
Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val Glu Ser Ser Lys Pro
    930                 935                 940                 
Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys Pro Val Gly Asn Ala
945                 950                 955                 960 
Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Ala Glu
                965                 970                 975     
Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp Glu Asn Leu Lys Ser
            980                 985                 990         
Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys Asn Asp Val Asn Cys
        995                 1000                1005            
Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu Lys Arg Ser Glu Ser
    1010                1015                1020                
Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu Gln Asp Val His Val
1025                1030                1035                1040
Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln Val Ser Ser Asp Pro
                1045                1050                1055    
Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys Thr Leu Lys Thr Thr
            1060                1065                1070        
Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu Cys Ser Val Ser Ile
        1075                1080                1085            
Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr Lys Cys Val Ala Lys
    1090                1095                1100                
Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln Val Thr Val Asp Asp
1105                1110                1115                1120
Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu Met Lys Ser Arg Arg
                1125                1130                1135    
Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr Glu Ser Asp Ala Thr
            1140                1145                1150        
Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro Lys Ala Ala Met Pro
        1155                1160                1165            
Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys Val Arg Ala Gly Glu
    1170                1175                1180                
Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr Gln Pro Ile Thr Cys
1185                1190                1195                1200
Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu Ser Glu His Met Lys
                1205                1210                1215    
Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr Ile Leu Ala Ala Arg
            1220                1225                1230        
Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val Glu Asn Lys Leu Gly
        1235                1240                1245            
Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val Asp Lys Pro Asp Pro
    1250                1255                1260                
Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg Ser Ser Ser Leu Thr
1265                1270                1275                1280
Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly Ser Ala Val Gln Ser
                1285                1290                1295    
Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys Thr Trp Lys Glu Leu
            1300                1305                1310        
Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln Asp Leu Leu Pro Asp
        1315                1320                1325            
His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn Val Tyr Gly Thr Ser
    1330                1335                1340                
Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val Gly Glu Lys Pro Glu
1345                1350                1355                1360
Glu Pro Lys Asp Glu Val Glu Val Ser Asp Asp Asp Glu Lys Glu Pro
                1365                1370                1375    
Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr Glu Gln Lys Val Ser
            1380                1385                1390        
Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser Gly Lys Phe Gly Gln
        1395                1400                1405            
Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys Val Trp Ala Gly Lys
    1410                1415                1420                
Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu Asn Ile Arg Gln Glu
1425                1430                1435                1440
Ile Ser Ile Met Asn Cys Leu His His Pro Lys Leu Val Gln Cys Val
                1445                1450                1455    
Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met Val Leu Glu Ile Val
            1460                1465                1470        
Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp Glu Asp Phe Glu Leu
        1475                1480                1485            
Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln Ile Ser Glu Gly Val
    1490                1495                1500                
Glu Tyr Ile His Lys Gln Gly Ile Val His Leu Asp Leu Lys Pro Glu
1505                1510                1515                1520
Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg Ile Lys Leu Ile Asp
                1525                1530                1535    
Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly Ser Leu Lys Val Leu
            1540                1545                1550        
Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val Ile Asn Tyr Glu Pro
        1555                1560                1565            
Ile Asp Ala Thr Asp Met Trp Ser Ile Gly Val Ile Cys Tyr Ile Leu
    1570                1575                1580                
Asn Arg Leu Asp Trp Leu Thr Gln Cys Leu Gln His Pro Trp Leu Met
1585                1590                1595                1600
Lys Asp Thr Lys Asn Met Glu Ala Lys Lys Leu Ser Lys Asp Arg Met
                1605                1610                1615    
Lys Lys Tyr Met Ala Arg Arg Lys Trp Gln Lys Thr Gly Asn Ala Val
            1620                1625                1630        
Arg Ala Ile Gly Arg Leu Ser Ser Met Ala Met Ile Ser Gly Leu Ser
        1635                1640                1645            
Gly Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser Pro Leu Asn Ala Glu
    1650                1655                1660                
Lys Leu Glu Ser Glu Glu Asp Val Ser Gln Ala Phe Leu Glu Ala Val
1665                1670                1675                1680
Ala Glu Glu Lys Pro His Val Lys Pro Tyr Phe Ser Lys Thr Ile Arg
                1685                1690                1695    
Asp Leu Glu Val Val Glu Gly Ser Ala Ala Arg Phe Asp Cys Lys Ile
            1700                1705                1710        
Glu Gly Tyr Pro Asp Pro Glu Val Val Trp Phe Lys Asp Asp Gln Ser
        1715                1720                1725            
Ile Arg Glu Ser Arg His Phe Gln Ile Asp Tyr Asp Glu Asp Gly Asn
    1730                1735                1740                
Cys Ser Leu Ile Ile Ser Asp Val Cys Gly Asp Asp Asp Ala Lys Tyr
1745                1750                1755                1760
Thr Cys Lys Ala Val Asn Ser Leu Gly Glu Ala Thr Cys Thr Ala Glu
                1765                1770                1775    
Leu Ile Val Glu Thr Met Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu
            1780                1785                1790        
Glu Glu
        


<210> 6088
<211> 1863
<212> PRT
<213> Homo sapiens

<400> 6088
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val Ala Trp Phe
        435                 440                 445             
Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr
    450                 455                 460                 
Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg
465                 470                 475                 480 
Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln Gly Gln Val
                485                 490                 495     
Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val Met Glu Val
            500                 505                 510         
Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly
        515                 520                 525             
Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg
    530                 535                 540                 
Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr
545                 550                 555                 560 
Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu
                565                 570                 575     
Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val
            580                 585                 590         
Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser Arg Lys
        595                 600                 605             
Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile
    610                 615                 620                 
Phe Leu Gln Gly Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val
625                 630                 635                 640 
Thr Met Thr Val Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp
                645                 650                 655     
Leu His Asn Gly Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu
            660                 665                 670         
Gln Arg Gly Thr Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu
        675                 680                 685             
Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val
    690                 695                 700                 
Arg Thr Gln Ala Val Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln
705                 710                 715                 720 
Pro Trp Phe Ile Ser Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln
                725                 730                 735     
Ser Val Leu Ile Ser Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val
            740                 745                 750         
His Trp Leu Arg Asp Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe
        755                 760                 765             
Glu Val Leu Gln Asn Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val
    770                 775                 780                 
Gln Pro Trp His Ala Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val
785                 790                 795                 800 
Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala
                805                 810                 815     
Arg Ala Leu Pro Arg Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys
            820                 825                 830         
Gly Gly Gly Val Gly Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser
        835                 840                 845             
Leu Arg Pro Gly Trp Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu
    850                 855                 860                 
Asp Gly Glu Asp Val Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg
865                 870                 875                 880 
Gln His Thr Glu Glu Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp
                885                 890                 895     
Phe Arg Asp Leu Leu Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu
            900                 905                 910         
Asp Asp Leu Lys Glu Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn
        915                 920                 925             
Leu Gln Arg Gln Val Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys
    930                 935                 940                 
Val His Ser Pro Gln Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys
945                 950                 955                 960 
Gly Thr Ser Lys Thr Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro
                965                 970                 975     
Ala Thr Pro Asp Phe Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro
            980                 985                 990         
Ala Glu Asn Gly Ser Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val
        995                 1000                1005            
Glu Ser Ser Lys Pro Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys
    1010                1015                1020                
Pro Val Gly Asn Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn
1025                1030                1035                1040
Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp
                1045                1050                1055    
Glu Asn Leu Lys Ser Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys
            1060                1065                1070        
Asn Asp Val Asn Cys Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu
        1075                1080                1085            
Lys Arg Ser Glu Ser Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu
    1090                1095                1100                
Gln Asp Val His Val Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln
1105                1110                1115                1120
Val Ser Ser Asp Pro Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys
                1125                1130                1135    
Thr Leu Lys Thr Thr Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu
            1140                1145                1150        
Cys Ser Val Ser Ile Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr
        1155                1160                1165            
Lys Cys Val Ala Lys Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln
    1170                1175                1180                
Val Thr Val Asp Asp Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu
1185                1190                1195                1200
Met Lys Ser Arg Arg Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr
                1205                1210                1215    
Glu Ser Asp Ala Thr Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro
            1220                1225                1230        
Lys Ala Ala Met Pro Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys
        1235                1240                1245            
Val Arg Ala Gly Glu Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr
    1250                1255                1260                
Gln Pro Ile Thr Cys Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu
1265                1270                1275                1280
Ser Glu His Met Lys Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr
                1285                1290                1295    
Ile Leu Ala Ala Arg Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val
            1300                1305                1310        
Glu Asn Lys Leu Gly Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val
        1315                1320                1325            
Asp Lys Pro Asp Pro Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg
    1330                1335                1340                
Ser Ser Ser Leu Thr Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly
1345                1350                1355                1360
Ser Ala Val Gln Ser Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys
                1365                1370                1375    
Thr Trp Lys Glu Leu Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln
            1380                1385                1390        
Asp Leu Leu Pro Asp His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn
        1395                1400                1405            
Val Tyr Gly Thr Ser Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val
    1410                1415                1420                
Gly Glu Lys Pro Glu Glu Pro Lys Met Lys Trp Arg Cys Gln Thr Asp
1425                1430                1435                1440
Asp Glu Lys Glu Pro Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr
                1445                1450                1455    
Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser
            1460                1465                1470        
Gly Lys Phe Gly Gln Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys
        1475                1480                1485            
Val Trp Ala Gly Lys Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu
    1490                1495                1500                
Asn Ile Arg Gln Glu Ile Ser Ile Met Asn Cys Leu His His Pro Lys
1505                1510                1515                1520
Leu Val Gln Cys Val Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met
                1525                1530                1535    
Val Leu Glu Ile Val Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp
            1540                1545                1550        
Glu Asp Phe Glu Leu Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln
        1555                1560                1565            
Ile Ser Glu Gly Val Glu Tyr Ile His Lys Gln Gly Ile Val His Leu
    1570                1575                1580                
Asp Leu Lys Pro Glu Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg
1585                1590                1595                1600
Ile Lys Leu Ile Asp Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly
                1605                1610                1615    
Ser Leu Lys Val Leu Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val
            1620                1625                1630        
Ile Asn Tyr Glu Pro Ile Gly Tyr Ala Thr Asp Met Trp Ser Ile Gly
        1635                1640                1645            
Val Ile Cys Tyr Ile Leu Asn Arg Leu Asp Cys Thr Gln Cys Leu Gln
    1650                1655                1660                
His Pro Trp Leu Met Lys Asp Thr Lys Asn Met Glu Ala Lys Lys Leu
1665                1670                1675                1680
Ser Lys Asp Arg Met Lys Lys Tyr Met Ala Arg Arg Lys Trp Gln Lys
                1685                1690                1695    
Thr Gly Asn Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Met Ala Met
            1700                1705                1710        
Ile Ser Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser
        1715                1720                1725            
Pro Leu Asn Ala Glu Lys Leu Glu Ser Glu Glu Asp Val Ser Gln Ala
    1730                1735                1740                
Phe Leu Glu Ala Val Ala Glu Glu Lys Pro His Val Lys Pro Tyr Phe
1745                1750                1755                1760
Ser Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser Ala Ala Arg
                1765                1770                1775    
Phe Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val Val Trp Phe
            1780                1785                1790        
Lys Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln Ile Asp Tyr
        1795                1800                1805            
Asp Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val Cys Gly Asp
    1810                1815                1820                
Asp Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu Gly Glu Ala
1825                1830                1835                1840
Thr Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu Gly Glu Gly
                1845                1850                1855    
Glu Gly Glu Glu Glu Glu Glu
            1860            


<210> 6089
<211> 1914
<212> PRT
<213> Homo sapiens

<400> 6089
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val Ala Trp Phe
        435                 440                 445             
Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr
    450                 455                 460                 
Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg
465                 470                 475                 480 
Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln Gly Gln Val
                485                 490                 495     
Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val Met Glu Val
            500                 505                 510         
Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly
        515                 520                 525             
Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg
    530                 535                 540                 
Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr
545                 550                 555                 560 
Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu
                565                 570                 575     
Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val
            580                 585                 590         
Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser Arg Lys
        595                 600                 605             
Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile
    610                 615                 620                 
Phe Leu Gln Gly Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val
625                 630                 635                 640 
Thr Met Thr Val Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp
                645                 650                 655     
Leu His Asn Gly Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu
            660                 665                 670         
Gln Arg Gly Thr Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu
        675                 680                 685             
Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val
    690                 695                 700                 
Arg Thr Gln Ala Val Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln
705                 710                 715                 720 
Pro Trp Phe Ile Ser Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln
                725                 730                 735     
Ser Val Leu Ile Ser Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val
            740                 745                 750         
His Trp Leu Arg Asp Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe
        755                 760                 765             
Glu Val Leu Gln Asn Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val
    770                 775                 780                 
Gln Pro Trp His Ala Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val
785                 790                 795                 800 
Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala
                805                 810                 815     
Arg Ala Leu Pro Arg Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys
            820                 825                 830         
Gly Gly Gly Val Gly Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser
        835                 840                 845             
Leu Arg Pro Gly Trp Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu
    850                 855                 860                 
Asp Gly Glu Asp Val Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg
865                 870                 875                 880 
Gln His Thr Glu Glu Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp
                885                 890                 895     
Phe Arg Asp Leu Leu Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu
            900                 905                 910         
Asp Asp Leu Lys Glu Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn
        915                 920                 925             
Leu Gln Arg Gln Val Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys
    930                 935                 940                 
Val His Ser Pro Gln Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys
945                 950                 955                 960 
Gly Thr Ser Lys Thr Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro
                965                 970                 975     
Ala Thr Pro Asp Phe Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro
            980                 985                 990         
Ala Glu Asn Gly Ser Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val
        995                 1000                1005            
Glu Ser Ser Lys Pro Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys
    1010                1015                1020                
Pro Val Gly Asn Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn
1025                1030                1035                1040
Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp
                1045                1050                1055    
Glu Asn Leu Lys Ser Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys
            1060                1065                1070        
Asn Asp Val Asn Cys Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu
        1075                1080                1085            
Lys Arg Ser Glu Ser Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu
    1090                1095                1100                
Gln Asp Val His Val Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln
1105                1110                1115                1120
Val Ser Ser Asp Pro Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys
                1125                1130                1135    
Thr Leu Lys Thr Thr Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu
            1140                1145                1150        
Cys Ser Val Ser Ile Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr
        1155                1160                1165            
Lys Cys Val Ala Lys Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln
    1170                1175                1180                
Val Thr Val Asp Asp Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu
1185                1190                1195                1200
Met Lys Ser Arg Arg Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr
                1205                1210                1215    
Glu Ser Asp Ala Thr Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro
            1220                1225                1230        
Lys Ala Ala Met Pro Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys
        1235                1240                1245            
Val Arg Ala Gly Glu Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr
    1250                1255                1260                
Gln Pro Ile Thr Cys Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu
1265                1270                1275                1280
Ser Glu His Met Lys Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr
                1285                1290                1295    
Ile Leu Ala Ala Arg Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val
            1300                1305                1310        
Glu Asn Lys Leu Gly Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val
        1315                1320                1325            
Asp Lys Pro Asp Pro Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg
    1330                1335                1340                
Ser Ser Ser Leu Thr Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly
1345                1350                1355                1360
Ser Ala Val Gln Ser Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys
                1365                1370                1375    
Thr Trp Lys Glu Leu Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln
            1380                1385                1390        
Asp Leu Leu Pro Asp His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn
        1395                1400                1405            
Val Tyr Gly Thr Ser Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val
    1410                1415                1420                
Gly Glu Lys Pro Glu Glu Pro Lys Asp Glu Val Glu Val Ser Asp Asp
1425                1430                1435                1440
Asp Glu Lys Glu Pro Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr
                1445                1450                1455    
Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser
            1460                1465                1470        
Gly Lys Phe Gly Gln Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys
        1475                1480                1485            
Val Trp Ala Gly Lys Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu
    1490                1495                1500                
Asn Ile Arg Gln Glu Ile Ser Ile Met Asn Cys Leu His His Pro Lys
1505                1510                1515                1520
Leu Val Gln Cys Val Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met
                1525                1530                1535    
Val Leu Glu Ile Val Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp
            1540                1545                1550        
Glu Asp Phe Glu Leu Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln
        1555                1560                1565            
Ile Ser Glu Gly Val Glu Tyr Ile His Lys Gln Gly Ile Val His Leu
    1570                1575                1580                
Asp Leu Lys Pro Glu Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg
1585                1590                1595                1600
Ile Lys Leu Ile Asp Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly
                1605                1610                1615    
Ser Leu Lys Val Leu Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val
            1620                1625                1630        
Ile Asn Tyr Glu Pro Ile Gly Tyr Ala Thr Asp Met Trp Ser Ile Gly
        1635                1640                1645            
Val Ile Cys Tyr Ile Leu Val Ser Gly Leu Ser Pro Phe Met Gly Asp
    1650                1655                1660                
Asn Asp Asn Glu Thr Leu Ala Asn Val Thr Ser Ala Thr Trp Asp Phe
1665                1670                1675                1680
Asp Asp Glu Ala Phe Asp Glu Ile Ser Asp Asp Ala Lys Asp Phe Ile
                1685                1690                1695    
Ser Asn Leu Leu Lys Lys Asp Met Lys Asn Arg Leu Asp Cys Thr Gln
            1700                1705                1710        
Cys Leu Gln His Pro Trp Leu Met Lys Asp Thr Lys Asn Met Glu Ala
        1715                1720                1725            
Lys Lys Leu Ser Lys Asp Arg Met Lys Lys Tyr Met Ala Arg Arg Lys
    1730                1735                1740                
Trp Gln Lys Thr Gly Asn Ala Val Arg Ala Ile Gly Arg Leu Ser Ser
1745                1750                1755                1760
Met Ala Met Ile Ser Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly Ser
                1765                1770                1775    
Pro Thr Ser Pro Leu Asn Ala Glu Lys Leu Glu Ser Glu Glu Asp Val
            1780                1785                1790        
Ser Gln Ala Phe Leu Glu Ala Val Ala Glu Glu Lys Pro His Val Lys
        1795                1800                1805            
Pro Tyr Phe Ser Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser
    1810                1815                1820                
Ala Ala Arg Phe Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val
1825                1830                1835                1840
Val Trp Phe Lys Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln
                1845                1850                1855    
Ile Asp Tyr Asp Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val
            1860                1865                1870        
Cys Gly Asp Asp Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu
        1875                1880                1885            
Gly Glu Ala Thr Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu
    1890                1895                1900                
Gly Glu Gly Glu Gly Glu Glu Glu Glu Glu
1905                1910                


<210> 6090
<211> 1794
<212> PRT
<213> Homo sapiens

<400> 6090
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Gly Leu Ala Val Met Glu Val Ala Pro Ser Phe Ser
        435                 440                 445             
Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly Gln Asp Phe Val Leu
    450                 455                 460                 
Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg Ile Thr Trp Leu Leu
465                 470                 475                 480 
Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr Cys Glu Ala Gly Val
                485                 490                 495     
Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu Asp His Gly Thr Tyr
            500                 505                 510         
Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val Ser Cys Ser Ala Trp
        515                 520                 525             
Val Thr Val His Glu Lys Lys Ser Ser Arg Lys Ser Glu Tyr Leu Leu
    530                 535                 540                 
Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile Phe Leu Gln Gly Leu
545                 550                 555                 560 
Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val Thr Met Thr Val Gln
                565                 570                 575     
Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp Leu His Asn Gly Asn
            580                 585                 590         
Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu Gln Arg Gly Thr Gln
        595                 600                 605             
His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu Asp Thr Gly Thr Tyr
    610                 615                 620                 
Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val Arg Thr Gln Ala Val
625                 630                 635                 640 
Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln Pro Trp Phe Ile Ser
                645                 650                 655     
Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln Ser Val Leu Ile Ser
            660                 665                 670         
Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val His Trp Leu Arg Asp
        675                 680                 685             
Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe Glu Val Leu Gln Asn
    690                 695                 700                 
Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val Gln Pro Trp His Ala
705                 710                 715                 720 
Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val Gly Glu Cys Ser Cys
                725                 730                 735     
Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala Arg Ala Leu Pro Arg
            740                 745                 750         
Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys Gly Gly Gly Val Gly
        755                 760                 765             
Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser Leu Arg Pro Gly Trp
    770                 775                 780                 
Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu Asp Gly Glu Asp Val
785                 790                 795                 800 
Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg Gln His Thr Glu Glu
                805                 810                 815     
Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp Phe Arg Asp Leu Leu
            820                 825                 830         
Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu Asp Asp Leu Lys Glu
        835                 840                 845             
Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn Leu Gln Arg Gln Val
    850                 855                 860                 
Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys Val His Ser Pro Gln
865                 870                 875                 880 
Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys Gly Thr Ser Lys Thr
                885                 890                 895     
Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro Ala Thr Pro Asp Phe
            900                 905                 910         
Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro Ala Glu Asn Gly Ser
        915                 920                 925             
Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val Glu Ser Ser Lys Pro
    930                 935                 940                 
Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys Pro Val Gly Asn Ala
945                 950                 955                 960 
Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Ala Glu
                965                 970                 975     
Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp Glu Asn Leu Lys Ser
            980                 985                 990         
Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys Asn Asp Val Asn Cys
        995                 1000                1005            
Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu Lys Arg Ser Glu Ser
    1010                1015                1020                
Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu Gln Asp Val His Val
1025                1030                1035                1040
Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln Val Ser Ser Asp Pro
                1045                1050                1055    
Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys Thr Leu Lys Thr Thr
            1060                1065                1070        
Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu Cys Ser Val Ser Ile
        1075                1080                1085            
Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr Lys Cys Val Ala Lys
    1090                1095                1100                
Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln Val Thr Val Asp Asp
1105                1110                1115                1120
Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu Met Lys Ser Arg Arg
                1125                1130                1135    
Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr Glu Ser Asp Ala Thr
            1140                1145                1150        
Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro Lys Ala Ala Met Pro
        1155                1160                1165            
Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys Val Arg Ala Gly Glu
    1170                1175                1180                
Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr Gln Pro Ile Thr Cys
1185                1190                1195                1200
Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu Ser Glu His Met Lys
                1205                1210                1215    
Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr Ile Leu Ala Ala Arg
            1220                1225                1230        
Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val Glu Asn Lys Leu Gly
        1235                1240                1245            
Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val Asp Lys Pro Asp Pro
    1250                1255                1260                
Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg Ser Ser Ser Leu Thr
1265                1270                1275                1280
Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly Ser Ala Val Gln Ser
                1285                1290                1295    
Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys Thr Trp Lys Glu Leu
            1300                1305                1310        
Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln Asp Leu Leu Pro Asp
        1315                1320                1325            
His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn Val Tyr Gly Thr Ser
    1330                1335                1340                
Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val Gly Glu Lys Pro Glu
1345                1350                1355                1360
Glu Pro Lys Met Lys Trp Arg Cys Gln Thr Asp Asp Glu Lys Glu Pro
                1365                1370                1375    
Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr Glu Gln Lys Val Ser
            1380                1385                1390        
Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser Gly Lys Phe Gly Gln
        1395                1400                1405            
Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys Val Trp Ala Gly Lys
    1410                1415                1420                
Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu Asn Ile Arg Gln Glu
1425                1430                1435                1440
Ile Ser Ile Met Asn Cys Leu His His Pro Lys Leu Val Gln Cys Val
                1445                1450                1455    
Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met Val Leu Glu Ile Val
            1460                1465                1470        
Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp Glu Asp Phe Glu Leu
        1475                1480                1485            
Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln Ile Ser Glu Gly Val
    1490                1495                1500                
Glu Tyr Ile His Lys Gln Gly Ile Val His Leu Asp Leu Lys Pro Glu
1505                1510                1515                1520
Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg Ile Lys Leu Ile Asp
                1525                1530                1535    
Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly Ser Leu Lys Val Leu
            1540                1545                1550        
Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val Ile Asn Tyr Glu Pro
        1555                1560                1565            
Ile Gly Tyr Ala Thr Asp Met Trp Ser Ile Gly Val Ile Cys Tyr Ile
    1570                1575                1580                
Leu Asn Arg Leu Asp Cys Thr Gln Cys Leu Gln His Pro Trp Leu Met
1585                1590                1595                1600
Lys Asp Thr Lys Asn Met Glu Ala Lys Lys Leu Ser Lys Asp Arg Met
                1605                1610                1615    
Lys Lys Tyr Met Ala Arg Arg Lys Trp Gln Lys Thr Gly Asn Ala Val
            1620                1625                1630        
Arg Ala Ile Gly Arg Leu Ser Ser Met Ala Met Ile Ser Gly Leu Ser
        1635                1640                1645            
Gly Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser Pro Leu Asn Ala Glu
    1650                1655                1660                
Lys Leu Glu Ser Glu Glu Asp Val Ser Gln Ala Phe Leu Glu Ala Val
1665                1670                1675                1680
Ala Glu Glu Lys Pro His Val Lys Pro Tyr Phe Ser Lys Thr Ile Arg
                1685                1690                1695    
Asp Leu Glu Val Val Glu Gly Ser Ala Ala Arg Phe Asp Cys Lys Ile
            1700                1705                1710        
Glu Gly Tyr Pro Asp Pro Glu Val Val Trp Phe Lys Asp Asp Gln Ser
        1715                1720                1725            
Ile Arg Glu Ser Arg His Phe Gln Ile Asp Tyr Asp Glu Asp Gly Asn
    1730                1735                1740                
Cys Ser Leu Ile Ile Ser Asp Val Cys Gly Asp Asp Asp Ala Lys Tyr
1745                1750                1755                1760
Thr Cys Lys Ala Val Asn Ser Leu Gly Glu Ala Thr Cys Thr Ala Glu
                1765                1770                1775    
Leu Ile Val Glu Thr Met Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu
            1780                1785                1790        
Glu Glu
        


<210> 6091
<211> 1841
<212> PRT
<213> Homo sapiens

<400> 6091
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val Ala Trp Phe
        435                 440                 445             
Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr
    450                 455                 460                 
Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg
465                 470                 475                 480 
Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln Gly Gln Val
                485                 490                 495     
Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val Met Glu Val
            500                 505                 510         
Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly
        515                 520                 525             
Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg
    530                 535                 540                 
Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr
545                 550                 555                 560 
Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu
                565                 570                 575     
Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val
            580                 585                 590         
Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser Arg Lys
        595                 600                 605             
Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile
    610                 615                 620                 
Phe Leu Gln Gly Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val
625                 630                 635                 640 
Thr Met Thr Val Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp
                645                 650                 655     
Leu His Asn Gly Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu
            660                 665                 670         
Gln Arg Gly Thr Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu
        675                 680                 685             
Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val
    690                 695                 700                 
Arg Thr Gln Ala Val Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln
705                 710                 715                 720 
Pro Trp Phe Ile Ser Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln
                725                 730                 735     
Ser Val Leu Ile Ser Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val
            740                 745                 750         
His Trp Leu Arg Asp Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe
        755                 760                 765             
Glu Val Leu Gln Asn Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val
    770                 775                 780                 
Gln Pro Trp His Ala Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val
785                 790                 795                 800 
Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala
                805                 810                 815     
Arg Ala Leu Pro Arg Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys
            820                 825                 830         
Gly Gly Gly Val Gly Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser
        835                 840                 845             
Leu Arg Pro Gly Trp Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu
    850                 855                 860                 
Asp Gly Glu Asp Val Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg
865                 870                 875                 880 
Gln His Thr Glu Glu Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp
                885                 890                 895     
Phe Arg Asp Leu Leu Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu
            900                 905                 910         
Asp Asp Leu Lys Glu Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn
        915                 920                 925             
Leu Gln Arg Gln Val Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys
    930                 935                 940                 
Val His Ser Pro Gln Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys
945                 950                 955                 960 
Gly Thr Ser Lys Thr Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro
                965                 970                 975     
Ala Thr Pro Asp Phe Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro
            980                 985                 990         
Ala Glu Asn Gly Ser Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val
        995                 1000                1005            
Glu Ser Ser Lys Pro Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys
    1010                1015                1020                
Pro Val Gly Asn Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn
1025                1030                1035                1040
Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp
                1045                1050                1055    
Glu Asn Leu Lys Ser Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys
            1060                1065                1070        
Asn Asp Val Asn Cys Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu
        1075                1080                1085            
Lys Arg Ser Glu Ser Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu
    1090                1095                1100                
Gln Asp Val His Val Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln
1105                1110                1115                1120
Val Ser Ser Asp Pro Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys
                1125                1130                1135    
Thr Leu Lys Thr Thr Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu
            1140                1145                1150        
Cys Ser Val Ser Ile Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr
        1155                1160                1165            
Lys Cys Val Ala Lys Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln
    1170                1175                1180                
Val Thr Val Asp Asp Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu
1185                1190                1195                1200
Met Lys Ser Arg Arg Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr
                1205                1210                1215    
Glu Ser Asp Ala Thr Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro
            1220                1225                1230        
Lys Ala Ala Met Pro Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys
        1235                1240                1245            
Val Arg Ala Gly Glu Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr
    1250                1255                1260                
Gln Pro Ile Thr Cys Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu
1265                1270                1275                1280
Ser Glu His Met Lys Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr
                1285                1290                1295    
Ile Leu Ala Ala Arg Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val
            1300                1305                1310        
Glu Asn Lys Leu Gly Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val
        1315                1320                1325            
Asp Lys Pro Asp Pro Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg
    1330                1335                1340                
Ser Ser Ser Leu Thr Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly
1345                1350                1355                1360
Ser Ala Val Gln Ser Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys
                1365                1370                1375    
Thr Trp Lys Glu Leu Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln
            1380                1385                1390        
Asp Leu Leu Pro Asp His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn
        1395                1400                1405            
Val Tyr Gly Thr Ser Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val
    1410                1415                1420                
Gly Glu Lys Pro Glu Glu Pro Lys Asp Glu Val Glu Val Ser Asp Asp
1425                1430                1435                1440
Asp Glu Lys Glu Pro Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr
                1445                1450                1455    
Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser
            1460                1465                1470        
Leu Phe Glu Arg Ile Ile Asp Glu Asp Phe Glu Leu Thr Glu Arg Glu
        1475                1480                1485            
Cys Ile Lys Tyr Met Arg Gln Ile Ser Glu Gly Val Glu Tyr Ile His
    1490                1495                1500                
Lys Gln Gly Ile Val His Leu Asp Leu Lys Pro Glu Asn Ile Met Cys
1505                1510                1515                1520
Val Asn Lys Thr Gly Thr Arg Ile Lys Leu Ile Asp Phe Gly Leu Ala
                1525                1530                1535    
Arg Arg Leu Glu Asn Ala Gly Ser Leu Lys Val Leu Phe Gly Thr Pro
            1540                1545                1550        
Glu Phe Val Ala Pro Glu Val Ile Asn Tyr Glu Pro Ile Gly Tyr Ala
        1555                1560                1565            
Thr Asp Met Trp Ser Ile Gly Val Ile Cys Tyr Ile Leu Val Ser Gly
    1570                1575                1580                
Leu Ser Pro Phe Met Gly Asp Asn Asp Asn Glu Thr Leu Ala Asn Val
1585                1590                1595                1600
Thr Ser Ala Thr Trp Asp Phe Asp Asp Glu Ala Phe Asp Glu Ile Ser
                1605                1610                1615    
Asp Asp Ala Lys Asp Phe Ile Ser Asn Leu Leu Lys Lys Asp Met Lys
            1620                1625                1630        
Asn Arg Leu Asp Cys Thr Gln Cys Leu Gln His Pro Trp Leu Met Lys
        1635                1640                1645            
Asp Thr Lys Asn Met Glu Ala Lys Lys Leu Ser Lys Asp Arg Met Lys
    1650                1655                1660                
Lys Tyr Met Ala Arg Arg Lys Trp Gln Lys Thr Gly Asn Ala Val Arg
1665                1670                1675                1680
Ala Ile Gly Arg Leu Ser Ser Met Ala Met Ile Ser Gly Leu Ser Gly
                1685                1690                1695    
Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser Pro Leu Asn Ala Glu Lys
            1700                1705                1710        
Leu Glu Ser Glu Glu Asp Val Ser Gln Ala Phe Leu Glu Ala Val Ala
        1715                1720                1725            
Glu Glu Lys Pro His Val Lys Pro Tyr Phe Ser Lys Thr Ile Arg Asp
    1730                1735                1740                
Leu Glu Val Val Glu Gly Ser Ala Ala Arg Phe Asp Cys Lys Ile Glu
1745                1750                1755                1760
Gly Tyr Pro Asp Pro Glu Val Val Trp Phe Lys Asp Asp Gln Ser Ile
                1765                1770                1775    
Arg Glu Ser Arg His Phe Gln Ile Asp Tyr Asp Glu Asp Gly Asn Cys
            1780                1785                1790        
Ser Leu Ile Ile Ser Asp Val Cys Gly Asp Asp Asp Ala Lys Tyr Thr
        1795                1800                1805            
Cys Lys Ala Val Asn Ser Leu Gly Glu Ala Thr Cys Thr Ala Glu Leu
    1810                1815                1820                
Ile Val Glu Thr Met Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Glu
1825                1830                1835                1840
Glu
    


<210> 6092
<211> 1845
<212> PRT
<213> Homo sapiens

<400> 6092
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Gly Leu Ala Val Met Glu Val Ala Pro Ser Phe Ser
        435                 440                 445             
Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly Gln Asp Phe Val Leu
    450                 455                 460                 
Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg Ile Thr Trp Leu Leu
465                 470                 475                 480 
Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr Cys Glu Ala Gly Val
                485                 490                 495     
Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu Asp His Gly Thr Tyr
            500                 505                 510         
Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val Ser Cys Ser Ala Trp
        515                 520                 525             
Val Thr Val His Glu Lys Lys Ser Ser Arg Lys Ser Glu Tyr Leu Leu
    530                 535                 540                 
Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile Phe Leu Gln Gly Leu
545                 550                 555                 560 
Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val Thr Met Thr Val Gln
                565                 570                 575     
Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp Leu His Asn Gly Asn
            580                 585                 590         
Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu Gln Arg Gly Thr Gln
        595                 600                 605             
His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu Asp Thr Gly Thr Tyr
    610                 615                 620                 
Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val Arg Thr Gln Ala Val
625                 630                 635                 640 
Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln Pro Trp Phe Ile Ser
                645                 650                 655     
Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln Ser Val Leu Ile Ser
            660                 665                 670         
Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val His Trp Leu Arg Asp
        675                 680                 685             
Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe Glu Val Leu Gln Asn
    690                 695                 700                 
Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val Gln Pro Trp His Ala
705                 710                 715                 720 
Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val Gly Glu Cys Ser Cys
                725                 730                 735     
Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala Arg Ala Leu Pro Arg
            740                 745                 750         
Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys Gly Gly Gly Val Gly
        755                 760                 765             
Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser Leu Arg Pro Gly Trp
    770                 775                 780                 
Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu Asp Gly Glu Asp Val
785                 790                 795                 800 
Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg Gln His Thr Glu Glu
                805                 810                 815     
Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp Phe Arg Asp Leu Leu
            820                 825                 830         
Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu Asp Asp Leu Lys Glu
        835                 840                 845             
Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn Leu Gln Arg Gln Val
    850                 855                 860                 
Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys Val His Ser Pro Gln
865                 870                 875                 880 
Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys Gly Thr Ser Lys Thr
                885                 890                 895     
Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro Ala Thr Pro Asp Phe
            900                 905                 910         
Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro Ala Glu Asn Gly Ser
        915                 920                 925             
Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val Glu Ser Ser Lys Pro
    930                 935                 940                 
Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys Pro Val Gly Asn Ala
945                 950                 955                 960 
Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Ala Glu
                965                 970                 975     
Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp Glu Asn Leu Lys Ser
            980                 985                 990         
Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys Asn Asp Val Asn Cys
        995                 1000                1005            
Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu Lys Arg Ser Glu Ser
    1010                1015                1020                
Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu Gln Asp Val His Val
1025                1030                1035                1040
Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln Val Ser Ser Asp Pro
                1045                1050                1055    
Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys Thr Leu Lys Thr Thr
            1060                1065                1070        
Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu Cys Ser Val Ser Ile
        1075                1080                1085            
Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr Lys Cys Val Ala Lys
    1090                1095                1100                
Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln Val Thr Val Asp Asp
1105                1110                1115                1120
Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu Met Lys Ser Arg Arg
                1125                1130                1135    
Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr Glu Ser Asp Ala Thr
            1140                1145                1150        
Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro Lys Ala Ala Met Pro
        1155                1160                1165            
Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys Val Arg Ala Gly Glu
    1170                1175                1180                
Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr Gln Pro Ile Thr Cys
1185                1190                1195                1200
Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu Ser Glu His Met Lys
                1205                1210                1215    
Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr Ile Leu Ala Ala Arg
            1220                1225                1230        
Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val Glu Asn Lys Leu Gly
        1235                1240                1245            
Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val Asp Lys Pro Asp Pro
    1250                1255                1260                
Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg Ser Ser Ser Leu Thr
1265                1270                1275                1280
Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly Ser Ala Val Gln Ser
                1285                1290                1295    
Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys Thr Trp Lys Glu Leu
            1300                1305                1310        
Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln Asp Leu Leu Pro Asp
        1315                1320                1325            
His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn Val Tyr Gly Thr Ser
    1330                1335                1340                
Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val Gly Glu Lys Pro Glu
1345                1350                1355                1360
Glu Pro Lys Asp Glu Val Glu Val Ser Asp Asp Asp Glu Lys Glu Pro
                1365                1370                1375    
Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr Glu Gln Lys Val Ser
            1380                1385                1390        
Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser Gly Lys Phe Gly Gln
        1395                1400                1405            
Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys Val Trp Ala Gly Lys
    1410                1415                1420                
Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu Asn Ile Arg Gln Glu
1425                1430                1435                1440
Ile Ser Ile Met Asn Cys Leu His His Pro Lys Leu Val Gln Cys Val
                1445                1450                1455    
Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met Val Leu Glu Ile Val
            1460                1465                1470        
Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp Glu Asp Phe Glu Leu
        1475                1480                1485            
Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln Ile Ser Glu Gly Val
    1490                1495                1500                
Glu Tyr Ile His Lys Gln Gly Ile Val His Leu Asp Leu Lys Pro Glu
1505                1510                1515                1520
Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg Ile Lys Leu Ile Asp
                1525                1530                1535    
Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly Ser Leu Lys Val Leu
            1540                1545                1550        
Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val Ile Asn Tyr Glu Pro
        1555                1560                1565            
Ile Gly Tyr Ala Thr Asp Met Trp Ser Ile Gly Val Ile Cys Tyr Ile
    1570                1575                1580                
Leu Val Ser Gly Leu Ser Pro Phe Met Gly Asp Asn Asp Asn Glu Thr
1585                1590                1595                1600
Leu Ala Asn Val Thr Ser Ala Thr Trp Asp Phe Asp Asp Glu Ala Phe
                1605                1610                1615    
Asp Glu Ile Ser Asp Asp Ala Lys Asp Phe Ile Ser Asn Leu Leu Lys
            1620                1625                1630        
Lys Asp Met Lys Asn Arg Leu Asp Cys Thr Gln Cys Leu Gln His Pro
        1635                1640                1645            
Trp Leu Met Lys Asp Thr Lys Asn Met Glu Ala Lys Lys Leu Ser Lys
    1650                1655                1660                
Asp Arg Met Lys Lys Tyr Met Ala Arg Arg Lys Trp Gln Lys Thr Gly
1665                1670                1675                1680
Asn Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Met Ala Met Ile Ser
                1685                1690                1695    
Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser Pro Leu
            1700                1705                1710        
Asn Ala Glu Lys Leu Glu Ser Glu Glu Asp Val Ser Gln Ala Phe Leu
        1715                1720                1725            
Glu Ala Val Ala Glu Glu Lys Pro His Val Lys Pro Tyr Phe Ser Lys
    1730                1735                1740                
Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser Ala Ala Arg Phe Asp
1745                1750                1755                1760
Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val Val Trp Phe Lys Asp
                1765                1770                1775    
Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln Ile Asp Tyr Asp Glu
            1780                1785                1790        
Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val Cys Gly Asp Asp Asp
        1795                1800                1805            
Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu Gly Glu Ala Thr Cys
    1810                1815                1820                
Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu Gly Glu Gly Glu Gly
1825                1830                1835                1840
Glu Glu Glu Glu Glu
                1845


<210> 6093
<211> 1863
<212> PRT
<213> Homo sapiens

<400> 6093
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val Ala Trp Phe
        435                 440                 445             
Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr
    450                 455                 460                 
Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg
465                 470                 475                 480 
Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln Gly Gln Val
                485                 490                 495     
Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val Met Glu Val
            500                 505                 510         
Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly
        515                 520                 525             
Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg
    530                 535                 540                 
Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr
545                 550                 555                 560 
Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu
                565                 570                 575     
Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val
            580                 585                 590         
Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser Arg Lys
        595                 600                 605             
Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile
    610                 615                 620                 
Phe Leu Gln Gly Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val
625                 630                 635                 640 
Thr Met Thr Val Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp
                645                 650                 655     
Leu His Asn Gly Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu
            660                 665                 670         
Gln Arg Gly Thr Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu
        675                 680                 685             
Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val
    690                 695                 700                 
Arg Thr Gln Ala Val Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln
705                 710                 715                 720 
Pro Trp Phe Ile Ser Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln
                725                 730                 735     
Ser Val Leu Ile Ser Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val
            740                 745                 750         
His Trp Leu Arg Asp Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe
        755                 760                 765             
Glu Val Leu Gln Asn Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val
    770                 775                 780                 
Gln Pro Trp His Ala Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val
785                 790                 795                 800 
Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala
                805                 810                 815     
Arg Ala Leu Pro Arg Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys
            820                 825                 830         
Gly Gly Gly Val Gly Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser
        835                 840                 845             
Leu Arg Pro Gly Trp Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu
    850                 855                 860                 
Asp Gly Glu Asp Val Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg
865                 870                 875                 880 
Gln His Thr Glu Glu Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp
                885                 890                 895     
Phe Arg Asp Leu Leu Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu
            900                 905                 910         
Asp Asp Leu Lys Glu Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn
        915                 920                 925             
Leu Gln Arg Gln Val Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys
    930                 935                 940                 
Val His Ser Pro Gln Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys
945                 950                 955                 960 
Gly Thr Ser Lys Thr Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro
                965                 970                 975     
Ala Thr Pro Asp Phe Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro
            980                 985                 990         
Ala Glu Asn Gly Ser Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val
        995                 1000                1005            
Glu Ser Ser Lys Pro Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys
    1010                1015                1020                
Pro Val Gly Asn Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn
1025                1030                1035                1040
Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp
                1045                1050                1055    
Glu Asn Leu Lys Ser Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys
            1060                1065                1070        
Asn Asp Val Asn Cys Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu
        1075                1080                1085            
Lys Arg Ser Glu Ser Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu
    1090                1095                1100                
Gln Asp Val His Val Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln
1105                1110                1115                1120
Val Ser Ser Asp Pro Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys
                1125                1130                1135    
Thr Leu Lys Thr Thr Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu
            1140                1145                1150        
Cys Ser Val Ser Ile Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr
        1155                1160                1165            
Lys Cys Val Ala Lys Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln
    1170                1175                1180                
Val Thr Val Asp Asp Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu
1185                1190                1195                1200
Met Lys Ser Arg Arg Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr
                1205                1210                1215    
Glu Ser Asp Ala Thr Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro
            1220                1225                1230        
Lys Ala Ala Met Pro Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys
        1235                1240                1245            
Val Arg Ala Gly Glu Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr
    1250                1255                1260                
Gln Pro Ile Thr Cys Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu
1265                1270                1275                1280
Ser Glu His Met Lys Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr
                1285                1290                1295    
Ile Leu Ala Ala Arg Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val
            1300                1305                1310        
Glu Asn Lys Leu Gly Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val
        1315                1320                1325            
Asp Lys Pro Asp Pro Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg
    1330                1335                1340                
Ser Ser Ser Leu Thr Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly
1345                1350                1355                1360
Ser Ala Val Gln Ser Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys
                1365                1370                1375    
Thr Trp Lys Glu Leu Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln
            1380                1385                1390        
Asp Leu Leu Pro Asp His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn
        1395                1400                1405            
Val Tyr Gly Thr Ser Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val
    1410                1415                1420                
Gly Glu Lys Pro Glu Glu Pro Lys Asp Glu Val Glu Val Ser Asp Asp
1425                1430                1435                1440
Asp Glu Lys Glu Pro Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr
                1445                1450                1455    
Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser
            1460                1465                1470        
Gly Lys Phe Gly Gln Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys
        1475                1480                1485            
Val Trp Ala Gly Lys Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu
    1490                1495                1500                
Asn Ile Arg Gln Glu Ile Ser Ile Met Asn Cys Leu His His Pro Lys
1505                1510                1515                1520
Leu Val Gln Cys Val Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met
                1525                1530                1535    
Val Leu Glu Ile Val Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp
            1540                1545                1550        
Glu Asp Phe Glu Leu Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln
        1555                1560                1565            
Ile Ser Glu Gly Val Glu Tyr Ile His Lys Gln Gly Ile Val His Leu
    1570                1575                1580                
Asp Leu Lys Pro Glu Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg
1585                1590                1595                1600
Ile Lys Leu Ile Asp Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly
                1605                1610                1615    
Ser Leu Lys Val Leu Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val
            1620                1625                1630        
Ile Asn Tyr Glu Pro Ile Gly Tyr Ala Thr Asp Met Trp Ser Ile Gly
        1635                1640                1645            
Val Ile Cys Tyr Ile Leu Asn Arg Leu Asp Cys Thr Gln Cys Leu Gln
    1650                1655                1660                
His Pro Trp Leu Met Lys Asp Thr Lys Asn Met Glu Ala Lys Lys Leu
1665                1670                1675                1680
Ser Lys Asp Arg Met Lys Lys Tyr Met Ala Arg Arg Lys Trp Gln Lys
                1685                1690                1695    
Thr Gly Asn Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Met Ala Met
            1700                1705                1710        
Ile Ser Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser
        1715                1720                1725            
Pro Leu Asn Ala Glu Lys Leu Glu Ser Glu Glu Asp Val Ser Gln Ala
    1730                1735                1740                
Phe Leu Glu Ala Val Ala Glu Glu Lys Pro His Val Lys Pro Tyr Phe
1745                1750                1755                1760
Ser Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser Ala Ala Arg
                1765                1770                1775    
Phe Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val Val Trp Phe
            1780                1785                1790        
Lys Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln Ile Asp Tyr
        1795                1800                1805            
Asp Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val Cys Gly Asp
    1810                1815                1820                
Asp Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu Gly Glu Ala
1825                1830                1835                1840
Thr Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu Gly Glu Gly
                1845                1850                1855    
Glu Gly Glu Glu Glu Glu Glu
            1860            


<210> 6094
<211> 1841
<212> PRT
<213> Homo sapiens

<400> 6094
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val Ala Trp Phe
        435                 440                 445             
Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr
    450                 455                 460                 
Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg
465                 470                 475                 480 
Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln Gly Gln Val
                485                 490                 495     
Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val Met Glu Val
            500                 505                 510         
Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly
        515                 520                 525             
Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg
    530                 535                 540                 
Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr
545                 550                 555                 560 
Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu
                565                 570                 575     
Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val
            580                 585                 590         
Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser Arg Lys
        595                 600                 605             
Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile
    610                 615                 620                 
Phe Leu Gln Gly Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val
625                 630                 635                 640 
Thr Met Thr Val Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp
                645                 650                 655     
Leu His Asn Gly Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu
            660                 665                 670         
Gln Arg Gly Thr Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu
        675                 680                 685             
Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val
    690                 695                 700                 
Arg Thr Gln Ala Val Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln
705                 710                 715                 720 
Pro Trp Phe Ile Ser Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln
                725                 730                 735     
Ser Val Leu Ile Ser Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val
            740                 745                 750         
His Trp Leu Arg Asp Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe
        755                 760                 765             
Glu Val Leu Gln Asn Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val
    770                 775                 780                 
Gln Pro Trp His Ala Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val
785                 790                 795                 800 
Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala
                805                 810                 815     
Arg Ala Leu Pro Arg Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys
            820                 825                 830         
Gly Gly Gly Val Gly Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser
        835                 840                 845             
Leu Arg Pro Gly Trp Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu
    850                 855                 860                 
Asp Gly Glu Asp Val Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg
865                 870                 875                 880 
Gln His Thr Glu Glu Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp
                885                 890                 895     
Phe Arg Asp Leu Leu Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu
            900                 905                 910         
Asp Asp Leu Lys Glu Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn
        915                 920                 925             
Leu Gln Arg Gln Val Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys
    930                 935                 940                 
Val His Ser Pro Gln Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys
945                 950                 955                 960 
Gly Thr Ser Lys Thr Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro
                965                 970                 975     
Ala Thr Pro Asp Phe Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro
            980                 985                 990         
Ala Glu Asn Gly Ser Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val
        995                 1000                1005            
Glu Ser Ser Lys Pro Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys
    1010                1015                1020                
Pro Val Gly Asn Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn
1025                1030                1035                1040
Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp
                1045                1050                1055    
Glu Asn Leu Lys Ser Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys
            1060                1065                1070        
Asn Asp Val Asn Cys Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu
        1075                1080                1085            
Lys Arg Ser Glu Ser Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu
    1090                1095                1100                
Gln Asp Val His Val Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln
1105                1110                1115                1120
Val Ser Ser Asp Pro Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys
                1125                1130                1135    
Thr Leu Lys Thr Thr Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu
            1140                1145                1150        
Cys Ser Val Ser Ile Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr
        1155                1160                1165            
Lys Cys Val Ala Lys Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln
    1170                1175                1180                
Val Thr Val Asp Asp Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu
1185                1190                1195                1200
Met Lys Ser Arg Arg Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr
                1205                1210                1215    
Glu Ser Asp Ala Thr Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro
            1220                1225                1230        
Lys Ala Ala Met Pro Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys
        1235                1240                1245            
Val Arg Ala Gly Glu Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr
    1250                1255                1260                
Gln Pro Ile Thr Cys Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu
1265                1270                1275                1280
Ser Glu His Met Lys Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr
                1285                1290                1295    
Ile Leu Ala Ala Arg Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val
            1300                1305                1310        
Glu Asn Lys Leu Gly Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val
        1315                1320                1325            
Asp Lys Pro Asp Pro Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg
    1330                1335                1340                
Ser Ser Ser Leu Thr Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly
1345                1350                1355                1360
Ser Ala Val Gln Ser Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys
                1365                1370                1375    
Thr Trp Lys Glu Leu Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln
            1380                1385                1390        
Asp Leu Leu Pro Asp His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn
        1395                1400                1405            
Val Tyr Gly Thr Ser Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val
    1410                1415                1420                
Gly Glu Lys Pro Glu Glu Pro Lys Met Lys Trp Arg Cys Gln Thr Asp
1425                1430                1435                1440
Asp Glu Lys Glu Pro Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr
                1445                1450                1455    
Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser
            1460                1465                1470        
Leu Phe Glu Arg Ile Ile Asp Glu Asp Phe Glu Leu Thr Glu Arg Glu
        1475                1480                1485            
Cys Ile Lys Tyr Met Arg Gln Ile Ser Glu Gly Val Glu Tyr Ile His
    1490                1495                1500                
Lys Gln Gly Ile Val His Leu Asp Leu Lys Pro Glu Asn Ile Met Cys
1505                1510                1515                1520
Val Asn Lys Thr Gly Thr Arg Ile Lys Leu Ile Asp Phe Gly Leu Ala
                1525                1530                1535    
Arg Arg Leu Glu Asn Ala Gly Ser Leu Lys Val Leu Phe Gly Thr Pro
            1540                1545                1550        
Glu Phe Val Ala Pro Glu Val Ile Asn Tyr Glu Pro Ile Gly Tyr Ala
        1555                1560                1565            
Thr Asp Met Trp Ser Ile Gly Val Ile Cys Tyr Ile Leu Val Ser Gly
    1570                1575                1580                
Leu Ser Pro Phe Met Gly Asp Asn Asp Asn Glu Thr Leu Ala Asn Val
1585                1590                1595                1600
Thr Ser Ala Thr Trp Asp Phe Asp Asp Glu Ala Phe Asp Glu Ile Ser
                1605                1610                1615    
Asp Asp Ala Lys Asp Phe Ile Ser Asn Leu Leu Lys Lys Asp Met Lys
            1620                1625                1630        
Asn Arg Leu Asp Cys Thr Gln Cys Leu Gln His Pro Trp Leu Met Lys
        1635                1640                1645            
Asp Thr Lys Asn Met Glu Ala Lys Lys Leu Ser Lys Asp Arg Met Lys
    1650                1655                1660                
Lys Tyr Met Ala Arg Arg Lys Trp Gln Lys Thr Gly Asn Ala Val Arg
1665                1670                1675                1680
Ala Ile Gly Arg Leu Ser Ser Met Ala Met Ile Ser Gly Leu Ser Gly
                1685                1690                1695    
Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser Pro Leu Asn Ala Glu Lys
            1700                1705                1710        
Leu Glu Ser Glu Glu Asp Val Ser Gln Ala Phe Leu Glu Ala Val Ala
        1715                1720                1725            
Glu Glu Lys Pro His Val Lys Pro Tyr Phe Ser Lys Thr Ile Arg Asp
    1730                1735                1740                
Leu Glu Val Val Glu Gly Ser Ala Ala Arg Phe Asp Cys Lys Ile Glu
1745                1750                1755                1760
Gly Tyr Pro Asp Pro Glu Val Val Trp Phe Lys Asp Asp Gln Ser Ile
                1765                1770                1775    
Arg Glu Ser Arg His Phe Gln Ile Asp Tyr Asp Glu Asp Gly Asn Cys
            1780                1785                1790        
Ser Leu Ile Ile Ser Asp Val Cys Gly Asp Asp Asp Ala Lys Tyr Thr
        1795                1800                1805            
Cys Lys Ala Val Asn Ser Leu Gly Glu Ala Thr Cys Thr Ala Glu Leu
    1810                1815                1820                
Ile Val Glu Thr Met Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Glu
1825                1830                1835                1840
Glu
    


<210> 6095
<211> 1913
<212> PRT
<213> Homo sapiens

<400> 6095
Met Gly Asp Val Lys Leu Val Ala Ser Ser His Ile Ser Lys Thr Ser
 1               5                  10                  15      
Leu Ser Val Asp Pro Ser Arg Val Asp Ser Met Pro Leu Thr Glu Ala
            20                  25                  30          
Pro Ala Phe Ile Leu Pro Pro Arg Asn Leu Cys Ile Lys Glu Gly Ala
        35                  40                  45              
Thr Ala Lys Phe Glu Gly Arg Val Arg Gly Tyr Pro Glu Pro Gln Val
    50                  55                  60                  
Thr Trp His Arg Asn Gly Gln Pro Ile Thr Ser Gly Gly Arg Phe Leu
65                  70                  75                  80  
Leu Asp Cys Gly Ile Arg Gly Thr Phe Ser Leu Val Ile His Ala Val
                85                  90                  95      
His Glu Glu Asp Arg Gly Lys Tyr Thr Cys Glu Ala Thr Asn Gly Ser
            100                 105                 110         
Gly Ala Arg Gln Val Thr Val Glu Leu Thr Val Glu Gly Ser Phe Ala
        115                 120                 125             
Lys Gln Leu Gly Gln Pro Val Val Ser Lys Thr Leu Gly Asp Arg Phe
    130                 135                 140                 
Ser Ala Ser Ala Val Glu Thr Arg Pro Ser Ile Trp Gly Glu Cys Pro
145                 150                 155                 160 
Pro Lys Phe Ala Thr Lys Leu Gly Arg Val Val Val Lys Glu Gly Gln
                165                 170                 175     
Met Gly Arg Phe Ser Cys Lys Ile Thr Gly Arg Pro Gln Pro Gln Val
            180                 185                 190         
Thr Trp Leu Lys Gly Asn Val Pro Leu Gln Pro Ser Ala Arg Val Ser
        195                 200                 205             
Val Ser Glu Lys Asn Gly Met Gln Val Leu Glu Ile His Gly Val Asn
    210                 215                 220                 
Gln Asp Asp Val Gly Val Tyr Thr Cys Leu Val Val Asn Gly Ser Gly
225                 230                 235                 240 
Lys Ala Ser Met Ser Ala Glu Leu Ser Ile Gln Gly Leu Asp Ser Ala
                245                 250                 255     
Asn Arg Ser Phe Val Arg Glu Thr Lys Ala Thr Asn Ser Asp Val Arg
            260                 265                 270         
Lys Glu Val Thr Asn Val Ile Ser Lys Glu Ser Lys Leu Asp Ser Leu
        275                 280                 285             
Glu Ala Ala Ala Lys Ser Lys Asn Cys Ser Ser Pro Gln Arg Gly Gly
    290                 295                 300                 
Ser Pro Pro Trp Ala Ala Asn Ser Gln Pro Gln Pro Pro Arg Glu Ser
305                 310                 315                 320 
Lys Leu Glu Ser Cys Lys Asp Ser Pro Arg Thr Ala Pro Gln Thr Pro
                325                 330                 335     
Val Leu Gln Lys Thr Ser Ser Ser Ile Thr Leu Gln Ala Ala Arg Val
            340                 345                 350         
Gln Pro Glu Pro Arg Ala Pro Gly Leu Gly Val Leu Ser Pro Ser Gly
        355                 360                 365             
Glu Glu Arg Lys Arg Pro Ala Pro Pro Arg Pro Ala Thr Phe Pro Thr
    370                 375                 380                 
Arg Gln Pro Gly Leu Gly Ser Gln Asp Val Val Ser Lys Ala Ala Asn
385                 390                 395                 400 
Arg Arg Ile Pro Met Glu Gly Gln Arg Asp Ser Ala Phe Pro Lys Phe
                405                 410                 415     
Glu Ser Lys Pro Gln Ser Gln Glu Val Lys Glu Asn Gln Thr Val Lys
            420                 425                 430         
Phe Arg Cys Glu Val Ser Gly Ile Pro Lys Pro Glu Val Ala Trp Phe
        435                 440                 445             
Leu Glu Gly Thr Pro Val Arg Arg Gln Glu Gly Ser Ile Glu Val Tyr
    450                 455                 460                 
Glu Asp Ala Gly Ser His Tyr Leu Cys Leu Leu Lys Ala Arg Thr Arg
465                 470                 475                 480 
Asp Ser Gly Thr Tyr Ser Cys Thr Ala Ser Asn Ala Gln Gly Gln Val
                485                 490                 495     
Ser Cys Ser Trp Thr Leu Gln Val Glu Arg Leu Ala Val Met Glu Val
            500                 505                 510         
Ala Pro Ser Phe Ser Ser Val Leu Lys Asp Cys Ala Val Ile Glu Gly
        515                 520                 525             
Gln Asp Phe Val Leu Gln Cys Ser Val Arg Gly Thr Pro Val Pro Arg
    530                 535                 540                 
Ile Thr Trp Leu Leu Asn Gly Gln Pro Ile Gln Tyr Ala Arg Ser Thr
545                 550                 555                 560 
Cys Glu Ala Gly Val Ala Glu Leu His Ile Gln Asp Ala Leu Pro Glu
                565                 570                 575     
Asp His Gly Thr Tyr Thr Cys Leu Ala Glu Asn Ala Leu Gly Gln Val
            580                 585                 590         
Ser Cys Ser Ala Trp Val Thr Val His Glu Lys Lys Ser Ser Arg Lys
        595                 600                 605             
Ser Glu Tyr Leu Leu Pro Val Ala Pro Ser Lys Pro Thr Ala Pro Ile
    610                 615                 620                 
Phe Leu Gln Gly Leu Ser Asp Leu Lys Val Met Asp Gly Ser Gln Val
625                 630                 635                 640 
Thr Met Thr Val Gln Val Ser Gly Asn Pro Pro Pro Glu Val Ile Trp
                645                 650                 655     
Leu His Asn Gly Asn Glu Ile Gln Glu Ser Glu Asp Phe His Phe Glu
            660                 665                 670         
Gln Arg Gly Thr Gln His Ser Leu Trp Ile Gln Glu Val Phe Pro Glu
        675                 680                 685             
Asp Thr Gly Thr Tyr Thr Cys Glu Ala Trp Asn Ser Ala Gly Glu Val
    690                 695                 700                 
Arg Thr Gln Ala Val Leu Thr Val Gln Glu Pro His Asp Gly Thr Gln
705                 710                 715                 720 
Pro Trp Phe Ile Ser Lys Pro Arg Ser Val Thr Ala Ser Leu Gly Gln
                725                 730                 735     
Ser Val Leu Ile Ser Cys Ala Ile Ala Gly Asp Pro Phe Pro Thr Val
            740                 745                 750         
His Trp Leu Arg Asp Gly Lys Ala Leu Cys Lys Asp Thr Gly His Phe
        755                 760                 765             
Glu Val Leu Gln Asn Glu Asp Val Phe Thr Leu Val Leu Lys Lys Val
    770                 775                 780                 
Gln Pro Trp His Ala Gly Gln Tyr Glu Ile Leu Leu Lys Asn Arg Val
785                 790                 795                 800 
Gly Glu Cys Ser Cys Gln Val Ser Leu Met Leu Gln Asn Ser Ser Ala
                805                 810                 815     
Arg Ala Leu Pro Arg Gly Arg Glu Pro Ala Ser Cys Glu Asp Leu Cys
            820                 825                 830         
Gly Gly Gly Val Gly Ala Asp Gly Gly Gly Ser Asp Arg Tyr Gly Ser
        835                 840                 845             
Leu Arg Pro Gly Trp Pro Ala Arg Gly Gln Gly Trp Leu Glu Glu Glu
    850                 855                 860                 
Asp Gly Glu Asp Val Arg Gly Val Leu Lys Arg Arg Val Glu Thr Arg
865                 870                 875                 880 
Gln His Thr Glu Glu Ala Ile Arg Gln Gln Glu Val Glu Gln Leu Asp
                885                 890                 895     
Phe Arg Asp Leu Leu Gly Lys Lys Val Ser Thr Lys Thr Leu Ser Glu
            900                 905                 910         
Asp Asp Leu Lys Glu Ile Pro Ala Glu Gln Met Asp Phe Arg Ala Asn
        915                 920                 925             
Leu Gln Arg Gln Val Lys Pro Lys Thr Val Ser Glu Glu Glu Arg Lys
    930                 935                 940                 
Val His Ser Pro Gln Gln Val Asp Phe Arg Ser Val Leu Ala Lys Lys
945                 950                 955                 960 
Gly Thr Ser Lys Thr Pro Val Pro Glu Lys Val Pro Pro Pro Lys Pro
                965                 970                 975     
Ala Thr Pro Asp Phe Arg Ser Val Leu Gly Gly Lys Lys Lys Leu Pro
            980                 985                 990         
Ala Glu Asn Gly Ser Ser Ser Ala Glu Thr Leu Asn Ala Lys Ala Val
        995                 1000                1005            
Glu Ser Ser Lys Pro Leu Ser Asn Ala Gln Pro Ser Gly Pro Leu Lys
    1010                1015                1020                
Pro Val Gly Asn Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn
1025                1030                1035                1040
Ala Lys Pro Ala Glu Thr Leu Lys Pro Met Gly Asn Ala Lys Pro Asp
                1045                1050                1055    
Glu Asn Leu Lys Ser Ala Ser Lys Glu Glu Leu Lys Lys Asp Val Lys
            1060                1065                1070        
Asn Asp Val Asn Cys Lys Arg Gly His Ala Gly Thr Thr Asp Asn Glu
        1075                1080                1085            
Lys Arg Ser Glu Ser Gln Gly Thr Ala Pro Ala Phe Lys Gln Lys Leu
    1090                1095                1100                
Gln Asp Val His Val Ala Glu Gly Lys Lys Leu Leu Leu Gln Cys Gln
1105                1110                1115                1120
Val Ser Ser Asp Pro Pro Ala Thr Ile Ile Trp Thr Leu Asn Gly Lys
                1125                1130                1135    
Thr Leu Lys Thr Thr Lys Phe Ile Ile Leu Ser Gln Glu Gly Ser Leu
            1140                1145                1150        
Cys Ser Val Ser Ile Glu Lys Ala Leu Pro Glu Asp Arg Gly Leu Tyr
        1155                1160                1165            
Lys Cys Val Ala Lys Asn Asp Ala Gly Gln Ala Glu Cys Ser Cys Gln
    1170                1175                1180                
Val Thr Val Asp Asp Ala Pro Ala Ser Glu Asn Thr Lys Ala Pro Glu
1185                1190                1195                1200
Met Lys Ser Arg Arg Pro Lys Ser Ser Leu Pro Pro Val Leu Gly Thr
                1205                1210                1215    
Glu Ser Asp Ala Thr Val Lys Lys Lys Pro Ala Pro Lys Thr Pro Pro
            1220                1225                1230        
Lys Ala Ala Met Pro Pro Gln Ile Ile Gln Phe Pro Glu Asp Gln Lys
        1235                1240                1245            
Val Arg Ala Gly Glu Ser Val Glu Leu Phe Gly Lys Val Thr Gly Thr
    1250                1255                1260                
Gln Pro Ile Thr Cys Thr Trp Met Lys Phe Arg Lys Gln Ile Gln Glu
1265                1270                1275                1280
Ser Glu His Met Lys Val Glu Asn Ser Glu Asn Gly Ser Lys Leu Thr
                1285                1290                1295    
Ile Leu Ala Ala Arg Gln Glu His Cys Gly Cys Tyr Thr Leu Leu Val
            1300                1305                1310        
Glu Asn Lys Leu Gly Ser Arg Gln Ala Gln Val Asn Leu Thr Val Val
        1315                1320                1325            
Asp Lys Pro Asp Pro Pro Ala Gly Thr Pro Cys Ala Ser Asp Ile Arg
    1330                1335                1340                
Ser Ser Ser Leu Thr Leu Ser Trp Tyr Gly Ser Ser Tyr Asp Gly Gly
1345                1350                1355                1360
Ser Ala Val Gln Ser Tyr Ser Ile Glu Ile Trp Asp Ser Ala Asn Lys
                1365                1370                1375    
Thr Trp Lys Glu Leu Ala Thr Cys Arg Ser Thr Ser Phe Asn Val Gln
            1380                1385                1390        
Asp Leu Leu Pro Asp His Glu Tyr Lys Phe Arg Val Arg Ala Ile Asn
        1395                1400                1405            
Val Tyr Gly Thr Ser Glu Pro Ser Gln Glu Ser Glu Leu Thr Thr Val
    1410                1415                1420                
Gly Glu Lys Pro Glu Glu Pro Lys Asp Glu Val Glu Val Ser Asp Asp
1425                1430                1435                1440
Asp Glu Lys Glu Pro Glu Val Asp Tyr Arg Thr Val Thr Ile Asn Thr
                1445                1450                1455    
Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly Ser
            1460                1465                1470        
Gly Lys Phe Gly Gln Val Phe Arg Leu Val Glu Lys Lys Thr Arg Lys
        1475                1480                1485            
Val Trp Ala Gly Lys Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys Glu
    1490                1495                1500                
Asn Ile Arg Gln Glu Ile Ser Ile Met Asn Cys Leu His His Pro Lys
1505                1510                1515                1520
Leu Val Gln Cys Val Asp Ala Phe Glu Glu Lys Ala Asn Ile Val Met
                1525                1530                1535    
Val Leu Glu Ile Val Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile Asp
            1540                1545                1550        
Glu Asp Phe Glu Leu Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg Gln
        1555                1560                1565            
Ile Ser Glu Gly Val Glu Tyr Ile His Lys Gln Gly Ile Val His Leu
    1570                1575                1580                
Asp Leu Lys Pro Glu Asn Ile Met Cys Val Asn Lys Thr Gly Thr Arg
1585                1590                1595                1600
Ile Lys Leu Ile Asp Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala Gly
                1605                1610                1615    
Ser Leu Lys Val Leu Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Val
            1620                1625                1630        
Ile Asn Tyr Glu Pro Ile Gly Tyr Ala Thr Asp Met Trp Ser Ile Gly
        1635                1640                1645            
Val Ile Cys Tyr Ile Leu Val Ser Gly Leu Ser Pro Phe Met Gly Asp
    1650                1655                1660                
Asn Asp Asn Glu Thr Leu Ala Asn Val Thr Ser Ala Thr Trp Asp Phe
1665                1670                1675                1680
Asp Asp Glu Ala Phe Asp Glu Ile Ser Asp Asp Ala Lys Asp Phe Ile
                1685                1690                1695    
Ser Asn Leu Leu Lys Lys Asp Met Lys Asn Arg Leu Asp Cys Thr Gln
            1700                1705                1710        
Cys Leu Gln His Pro Trp Leu Met Lys Asp Thr Lys Asn Met Glu Ala
        1715                1720                1725            
Lys Lys Leu Ser Lys Asp Arg Met Lys Lys Tyr Met Ala Arg Arg Lys
    1730                1735                1740                
Trp Gln Lys Thr Gly Asn Ala Val Arg Ala Ile Gly Arg Leu Ser Ser
1745                1750                1755                1760
Met Ala Met Ile Ser Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly Ser
                1765                1770                1775    
Pro Thr Ser Pro Leu Asn Ala Glu Lys Leu Glu Ser Glu Asp Val Ser
            1780                1785                1790        
Gln Ala Phe Leu Glu Ala Val Ala Glu Glu Lys Pro His Val Lys Pro
        1795                1800                1805            
Tyr Phe Ser Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser Ala
    1810                1815                1820                
Ala Arg Phe Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val Val
1825                1830                1835                1840
Trp Phe Lys Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln Ile
                1845                1850                1855    
Asp Tyr Asp Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val Cys
            1860                1865                1870        
Gly Asp Asp Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu Gly
        1875                1880                1885            
Glu Ala Thr Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu Gly
    1890                1895                1900                
Glu Gly Glu Gly Glu Glu Glu Glu Glu
1905                1910            


<210> 6096
<211> 473
<212> PRT
<213> Homo sapiens

<400> 6096
Met Ala Gln His Asp Phe Ala Pro Ala Trp Leu Asn Phe Pro Thr Pro
 1               5                  10                  15      
Pro Ser Ser Thr Lys Ser Ser Leu Asn Phe Glu Lys His Ser Glu Asn
            20                  25                  30          
Phe Ala Trp Thr Glu Asn Arg Tyr Asp Val Asn Arg Arg Arg His Asn
        35                  40                  45              
Ser Ser Asp Gly Phe Asp Ser Ala Ile Gly Arg Pro Asn Gly Gly Asn
    50                  55                  60                  
Phe Gly Arg Lys Glu Lys Asn Gly Trp Arg Thr His Gly Arg Asn Gly
65                  70                  75                  80  
Thr Glu Asn Ile Asn His Arg Gly Gly Tyr His Gly Gly Ser Ser Arg
                85                  90                  95      
Ser Arg Ser Ser Ile Phe His Ala Gly Lys Ser Gln Gly Leu His Glu
            100                 105                 110         
Asn Asn Ile Pro Asp Asn Glu Thr Gly Arg Lys Glu Asp Lys Arg Glu
        115                 120                 125             
Arg Lys Gln Phe Glu Ala Glu Asp Phe Pro Ser Leu Asn Pro Glu Tyr
    130                 135                 140                 
Glu Arg Glu Pro Asn His Asn Lys Ser Leu Ala Ala Gly Val Trp Glu
145                 150                 155                 160 
Tyr Pro Pro Asn Pro Lys Ser Arg Ala Pro Arg Met Leu Val Ile Lys
                165                 170                 175     
Lys Gly Asn Thr Lys Asp Leu Gln Leu Ser Gly Phe Pro Val Val Gly
            180                 185                 190         
Asn Leu Pro Ser Gln Pro Val Lys Asn Gly Thr Gly Pro Ser Val Tyr
        195                 200                 205             
Lys Gly Leu Val Pro Lys Pro Ala Ala Pro Pro Thr Lys Pro Thr Gln
    210                 215                 220                 
Trp Lys Ser Gln Thr Lys Glu Asn Lys Val Gly Thr Ser Phe Pro His
225                 230                 235                 240 
Glu Ser Thr Phe Gly Val Gly Asn Phe Asn Ala Phe Lys Ser Thr Ala
                245                 250                 255     
Lys Asn Phe Ser Pro Ser Thr Asn Ser Val Lys Glu Cys Asn Arg Ser
            260                 265                 270         
Asn Ser Ser Ser Pro Val Asp Lys Leu Asn Gln Gln Pro Arg Leu Thr
        275                 280                 285             
Lys Leu Thr Arg Met Arg Thr Asp Lys Lys Ser Glu Phe Leu Lys Ala
    290                 295                 300                 
Leu Lys Arg Asp Arg Val Glu Glu Glu His Glu Asp Glu Ser Arg Ala
305                 310                 315                 320 
Gly Ser Glu Lys Asp Asp Asp Ser Phe Asn Leu His Asn Ser Asn Ser
                325                 330                 335     
Thr His Gln Glu Arg Asp Ile Asn Arg Asn Phe Asp Glu Asn Glu Ile
            340                 345                 350         
Pro Gln Glu Asn Gly Asn Ala Ser Val Ile Ser Gln Gln Ile Ile Arg
        355                 360                 365             
Ser Ser Thr Phe Pro Gln Thr Asp Val Leu Ser Ser Ser Leu Glu Ala
    370                 375                 380                 
Glu His Arg Leu Leu Lys Glu Met Gly Trp Gln Glu Asp Ser Glu Asn
385                 390                 395                 400 
Asp Glu Thr Cys Ala Pro Leu Thr Glu Asp Glu Met Arg Glu Phe Gln
                405                 410                 415     
Val Ile Ser Glu Gln Leu Gln Lys Asn Gly Leu Arg Lys Asn Gly Ile
            420                 425                 430         
Leu Lys Asn Gly Leu Ile Cys Asp Phe Lys Phe Gly Pro Trp Lys Asn
        435                 440                 445             
Ser Thr Phe Lys Pro Thr Thr Glu Asn Asp Asp Thr Glu Thr Ser Ser
    450                 455                 460                 
Ser Asp Thr Ser Asp Asp Asp Asp Val
465                 470             


<210> 6097
<211> 492
<212> PRT
<213> Homo sapiens

<400> 6097
Val Lys Tyr Leu Gln Arg Thr Ser Ile Leu Phe Gln Arg Ile Gln Asn
 1               5                  10                  15      
Lys Asn Thr Asn Trp Lys Ile Lys Ile Thr Glu Lys Lys Pro Thr Pro
            20                  25                  30          
Ser Cys Ala Val Leu Leu Glu Phe Ser Ser Leu Asn Phe Glu Lys His
        35                  40                  45              
Ser Glu Asn Phe Ala Trp Thr Glu Asn Arg Tyr Asp Val Asn Arg Arg
    50                  55                  60                  
Arg His Asn Ser Ser Asp Gly Phe Asp Ser Ala Ile Gly Arg Pro Asn
65                  70                  75                  80  
Gly Gly Asn Phe Gly Arg Lys Glu Lys Asn Gly Trp Arg Thr His Gly
                85                  90                  95      
Arg Asn Gly Thr Glu Asn Ile Asn His Arg Gly Gly Tyr His Gly Gly
            100                 105                 110         
Ser Ser Arg Ser Arg Ser Ser Ile Phe His Ala Gly Lys Ser Gln Gly
        115                 120                 125             
Leu His Glu Asn Asn Ile Pro Asp Asn Glu Thr Gly Arg Lys Glu Asp
    130                 135                 140                 
Lys Arg Glu Arg Lys Gln Phe Glu Ala Glu Asp Phe Pro Ser Leu Asn
145                 150                 155                 160 
Pro Glu Tyr Glu Arg Glu Pro Asn His Asn Lys Ser Leu Ala Ala Gly
                165                 170                 175     
Val Trp Glu Tyr Pro Pro Asn Pro Lys Ser Arg Ala Pro Arg Met Leu
            180                 185                 190         
Val Ile Lys Lys Gly Asn Thr Lys Asp Leu Gln Leu Ser Gly Phe Pro
        195                 200                 205             
Val Val Gly Asn Leu Pro Ser Gln Pro Val Lys Asn Gly Thr Gly Pro
    210                 215                 220                 
Ser Val Tyr Lys Gly Leu Val Pro Lys Pro Ala Ala Pro Pro Thr Lys
225                 230                 235                 240 
Pro Thr Gln Trp Lys Ser Gln Thr Lys Glu Asn Lys Val Gly Thr Ser
                245                 250                 255     
Phe Pro His Glu Ser Thr Phe Gly Val Gly Asn Phe Asn Ala Phe Lys
            260                 265                 270         
Ser Thr Ala Lys Asn Phe Ser Pro Ser Thr Asn Ser Val Lys Glu Cys
        275                 280                 285             
Asn Arg Ser Asn Ser Ser Ser Pro Val Asp Lys Leu Asn Gln Gln Pro
    290                 295                 300                 
Arg Leu Thr Lys Leu Thr Arg Met Arg Thr Asp Lys Lys Ser Glu Phe
305                 310                 315                 320 
Leu Lys Ala Leu Lys Arg Asp Arg Val Glu Glu Glu His Glu Asp Glu
                325                 330                 335     
Ser Arg Ala Gly Ser Glu Lys Asp Asp Asp Ser Phe Asn Leu His Asn
            340                 345                 350         
Ser Asn Ser Thr His Gln Glu Arg Asp Ile Asn Arg Asn Phe Asp Glu
        355                 360                 365             
Asn Glu Ile Pro Gln Glu Asn Gly Asn Ala Ser Val Ile Ser Gln Gln
    370                 375                 380                 
Ile Ile Arg Ser Ser Thr Phe Pro Gln Thr Asp Val Leu Ser Ser Ser
385                 390                 395                 400 
Leu Glu Ala Glu His Arg Leu Leu Lys Glu Met Gly Trp Gln Glu Asp
                405                 410                 415     
Ser Glu Asn Asp Glu Thr Cys Ala Pro Leu Thr Glu Asp Glu Met Arg
            420                 425                 430         
Glu Phe Gln Val Ile Ser Glu Gln Leu Gln Lys Asn Gly Leu Arg Lys
        435                 440                 445             
Asn Gly Ile Leu Lys Asn Gly Leu Ile Cys Asp Phe Lys Phe Gly Pro
    450                 455                 460                 
Trp Lys Asn Ser Thr Phe Lys Pro Thr Thr Glu Asn Asp Asp Thr Glu
465                 470                 475                 480 
Thr Ser Ser Ser Asp Thr Ser Asp Asp Asp Asp Val
                485                 490         


<210> 6098
<211> 166
<212> PRT
<213> Homo sapiens

<400> 6098
Met Lys Gln Leu Pro Ala Ala Thr Val Arg Leu Leu Ser Ser Ser Gln
 1               5                  10                  15      
Ile Ile Thr Ser Val Val Ser Val Val Lys Glu Leu Ile Glu Asn Ser
            20                  25                  30          
Leu Asp Ala Gly Ala Thr Ser Val Asp Val Lys Leu Glu Asn Tyr Gly
        35                  40                  45              
Phe Asp Lys Ile Glu Val Arg Asp Asn Gly Glu Gly Ile Lys Ala Val
    50                  55                  60                  
Asp Ala Pro Val Met Ala Met Lys Tyr Tyr Thr Ser Lys Ile Asn Ser
65                  70                  75                  80  
His Glu Asp Leu Glu Asn Leu Thr Thr Tyr Gly Phe Arg Gly Glu Ala
                85                  90                  95      
Leu Gly Ser Ile Cys Cys Ile Ala Glu Val Leu Ile Thr Thr Arg Thr
            100                 105                 110         
Ala Ala Asp Asn Phe Ser Thr Gln Tyr Val Leu Asp Gly Ser Gly His
        115                 120                 125             
Ile Leu Ser Gln Lys Pro Ser His Leu Gly Gln Gly Lys Lys Val Ala
    130                 135                 140                 
Leu Tyr Thr Asn Ile Leu Tyr Leu Phe Cys Leu Asn Cys Trp Phe Lys
145                 150                 155                 160 
Lys Lys Lys Val Thr Arg
                165     


<210> 6099
<211> 315
<212> PRT
<213> Homo sapiens

<400> 6099
Met Ala Thr Pro Tyr Val Pro Val Pro Met Pro Ile Gly Asn Ser Ala
 1               5                  10                  15      
Ser Ser Phe Thr Thr Asn Arg Asn Gln Arg Ser Ser Ser Phe Gly Ser
            20                  25                  30          
Val Ser Thr Ser Ser Asn Ser Ser Lys Gly Gln Leu Glu Asp Ser Asn
        35                  40                  45              
Met Gly Asn Phe Lys Gln Thr Ser Val Pro Asp Gln Met Asp Asn Thr
    50                  55                  60                  
Ser Ser Val Cys Ser Ser Pro Leu Ile Arg Thr Lys Phe Thr Gly Thr
65                  70                  75                  80  
Ala Ser Ser Ile Glu Tyr Ser Thr Arg Pro Arg Asp Thr Glu Glu Gln
                85                  90                  95      
Asn Pro Glu Thr Val Asn Trp Glu Asp Arg Pro Ser Thr Pro Thr Ile
            100                 105                 110         
Leu Gly Tyr Glu Val Met Glu Glu Arg Ala Lys Phe Thr Leu Lys Glu
        115                 120                 125             
Met Phe Pro Gly Phe Arg Leu Ala Leu Pro Pro Lys Arg Trp Phe Lys
    130                 135                 140                 
Asp Asn Tyr Asn Ala Asp Phe Leu Glu Asp Arg Gln Leu Gly Leu Gln
145                 150                 155                 160 
Ala Phe Leu Gln Asn Leu Val Ala His Lys Asp Ile Ala Asn Cys Leu
                165                 170                 175     
Ala Val Arg Glu Phe Leu Cys Leu Asp Asp Pro Pro Gly Pro Phe Asp
            180                 185                 190         
Ser Leu Glu Glu Ser Arg Ala Phe Cys Glu Thr Leu Glu Glu Thr Asn
        195                 200                 205             
Tyr Arg Leu Gln Lys Glu Leu Leu Glu Lys Gln Lys Glu Met Glu Ser
    210                 215                 220                 
Leu Lys Lys Leu Leu Ser Glu Lys Gln Leu His Ile Asp Thr Leu Glu
225                 230                 235                 240 
Asn Arg Ile Arg Thr Leu Ser Leu Glu Pro Glu Glu Ser Leu Asp Val
                245                 250                 255     
Ser Glu Thr Glu Gly Glu Gln Ile Leu Lys Val Glu Ser Ser Ala Leu
            260                 265                 270         
Glu Val Asp Gln Asp Val Leu Asp Glu Glu Ser Arg Ala Asp Asn Lys
        275                 280                 285             
Pro Cys Leu Ser Phe Ser Glu Pro Glu Asn Ala Val Ser Glu Ile Glu
    290                 295                 300                 
Val Ala Glu Val Ala Tyr Asp Ala Glu Glu Asp
305                 310                 315 


<210> 6100
<211> 344
<212> PRT
<213> Homo sapiens

<400> 6100
Met Ala Thr Pro Tyr Val Pro Val Pro Met Pro Ile Gly Asn Ser Ala
 1               5                  10                  15      
Ser Ser Phe Thr Thr Asn Arg Asn Gln Arg Ser Ser Ser Phe Gly Ser
            20                  25                  30          
Val Ser Thr Ser Ser Asn Ser Ser Lys Gly Gln Leu Glu Asp Ser Asn
        35                  40                  45              
Met Gly Asn Phe Lys Gln Thr Ser Val Pro Asp Gln Met Asp Asn Thr
    50                  55                  60                  
Ser Ser Val Cys Ser Ser Pro Leu Ile Arg Thr Lys Phe Thr Gly Thr
65                  70                  75                  80  
Ala Ser Ser Ile Glu Tyr Ser Thr Arg Pro Arg Asp Thr Glu Glu Gln
                85                  90                  95      
Asn Pro Glu Thr Val Asn Trp Glu Asp Arg Pro Ser Thr Pro Thr Ile
            100                 105                 110         
Leu Gly Tyr Glu Val Met Glu Glu Arg Ala Lys Phe Thr Val Tyr Lys
        115                 120                 125             
Ile Leu Val Lys Lys Thr Pro Glu Glu Ser Trp Val Val Phe Arg Arg
    130                 135                 140                 
Tyr Thr Asp Phe Ser Arg Leu Asn Asp Lys Leu Lys Glu Met Phe Pro
145                 150                 155                 160 
Gly Phe Arg Leu Ala Leu Pro Pro Lys Arg Trp Phe Lys Asp Asn Tyr
                165                 170                 175     
Asn Ala Asp Phe Leu Glu Asp Arg Gln Leu Gly Leu Gln Ala Phe Leu
            180                 185                 190         
Gln Asn Leu Val Ala His Lys Asp Ile Ala Asn Cys Leu Ala Val Arg
        195                 200                 205             
Glu Phe Leu Cys Leu Asp Asp Pro Pro Gly Pro Phe Asp Ser Leu Glu
    210                 215                 220                 
Glu Ser Arg Ala Phe Cys Glu Thr Leu Glu Glu Thr Asn Tyr Arg Leu
225                 230                 235                 240 
Gln Lys Glu Leu Leu Glu Lys Gln Lys Glu Met Glu Ser Leu Lys Lys
                245                 250                 255     
Leu Leu Ser Glu Lys Gln Leu His Ile Asp Thr Leu Glu Asn Arg Ile
            260                 265                 270         
Arg Thr Leu Ser Leu Glu Pro Glu Glu Ser Leu Asp Val Ser Glu Thr
        275                 280                 285             
Glu Gly Glu Gln Ile Leu Lys Val Glu Ser Ser Ala Leu Glu Val Asp
    290                 295                 300                 
Gln Asp Val Leu Asp Glu Glu Ser Arg Ala Asp Asn Lys Pro Cys Leu
305                 310                 315                 320 
Ser Phe Ser Glu Pro Glu Asn Ala Val Ser Glu Ile Glu Val Ala Glu
                325                 330                 335     
Val Ala Tyr Asp Ala Glu Glu Asp
            340                 


<210> 6101
<211> 684
<212> PRT
<213> Homo sapiens

<400> 6101
Met Ala Glu Gly Glu Asp Val Pro Pro Leu Pro Thr Ser Ser Gly Asp
 1               5                  10                  15      
Gly Trp Glu Lys Asp Leu Glu Glu Ala Leu Glu Ala Gly Gly Cys Asp
            20                  25                  30          
Leu Glu Thr Leu Arg Asn Ile Ile Gln Gly Arg Pro Leu Pro Ala Asp
        35                  40                  45              
Leu Arg Ala Lys Val Trp Lys Ile Ala Leu Asn Val Ala Gly Lys Gly
    50                  55                  60                  
Asp Cys Leu Ala Ser Trp Asp Gly Ile Leu Asp Leu Pro Glu Gln Asn
65                  70                  75                  80  
Thr Ile His Lys Asp Cys Leu Gln Phe Ile Asp Gln Leu Ser Val Pro
                85                  90                  95      
Glu Glu Lys Ala Ala Glu Leu Leu Leu Asp Ile Glu Ser Val Ile Thr
            100                 105                 110         
Phe Tyr Cys Lys Ser Arg Asn Ile Lys Tyr Ser Thr Ser Leu Ser Trp
        115                 120                 125             
Ile His Leu Leu Lys Pro Leu Val His Leu Gln Leu Pro Arg Ser Asp
    130                 135                 140                 
Leu Tyr Asn Cys Phe Tyr Ala Ile Met Asn Lys Tyr Ile Pro Arg Asp
145                 150                 155                 160 
Cys Ser Gln Lys Gly Arg Pro Phe His Pro Phe Arg Leu Leu Ile Gln
                165                 170                 175     
Tyr His Glu Pro Glu Leu Cys Ser Tyr Leu Asp Thr Lys Lys Ile Thr
            180                 185                 190         
Pro Asp Ser Tyr Ala Leu Asn Trp Leu Gly Ser Leu Phe Ala Cys Tyr
        195                 200                 205             
Cys Ser Thr Glu Val Thr Gln Ala Ile Trp Asp Gly Tyr Leu Gln Gln
    210                 215                 220                 
Ala Asp Pro Phe Phe Ile Tyr Phe Leu Met Leu Ile Ile Leu Val Asn
225                 230                 235                 240 
Ala Lys Glu Val Ile Leu Thr Gln Glu Ser Asp Ser Lys Glu Glu Val
                245                 250                 255     
Ile Lys Phe Leu Glu Asn Thr Pro Ser Ser Leu Asn Ile Glu Asp Ile
            260                 265                 270         
Glu Asp Leu Phe Ser Leu Ala Gln Tyr Tyr Cys Ser Lys Thr Pro Ala
        275                 280                 285             
Ser Phe Arg Lys Asp Asn His His Leu Phe Gly Ser Thr Leu Leu Gly
    290                 295                 300                 
Ile Lys Asp Asp Asp Ala Asp Leu Ser Gln Ala Leu Cys Leu Ala Ile
305                 310                 315                 320 
Ser Val Ser Glu Ile Leu Gln Ala Asn Gln Leu Gln Gly Glu Gly Val
                325                 330                 335     
Arg Phe Phe Val Val Asp Cys Arg Pro Ala Glu Gln Tyr Asn Ala Gly
            340                 345                 350         
His Leu Ser Thr Ala Phe His Ser Asp Ser Asp Leu Met Leu Gln Asn
        355                 360                 365             
Pro Ser Glu Phe Ala Gln Ser Val Lys Ser Leu Leu Glu Ala Gln Lys
    370                 375                 380                 
Gln Ser Ile Glu Ser Gly Ser Ile Ala Gly Gly Glu His Leu Cys Phe
385                 390                 395                 400 
Met Gly Ser Gly Arg Glu Glu Glu Asp Met Tyr Met Asn Met Val Leu
                405                 410                 415     
Ala His Phe Leu Gln Lys Asn Lys Glu Tyr Val Ser Ile Ala Ser Gly
            420                 425                 430         
Gly Phe Met Ala Leu Gln Gln His Leu Ala Asp Ile Asn Val Asp Gly
        435                 440                 445             
Pro Glu Asn Gly Tyr Gly His Trp Ile Ala Ser Thr Ser Gly Ser Arg
    450                 455                 460                 
Ser Ser Ile Asn Ser Val Asp Gly Glu Ser Pro Asn Gly Ser Ser Asp
465                 470                 475                 480 
Arg Gly Met Lys Ser Leu Val Asn Lys Met Thr Val Ala Leu Lys Thr
                485                 490                 495     
Lys Ser Val Asn Val Arg Glu Lys Val Ile Ser Phe Ile Glu Asn Thr
            500                 505                 510         
Ser Thr Pro Val Asp Arg His Val Ser Ser Ser Asp Arg Val Gly Lys
        515                 520                 525             
Pro Tyr Arg Gly Val Lys Pro Val Phe Ser Ile Gly Asp Glu Glu Glu
    530                 535                 540                 
Tyr Asp Thr Asp Glu Ile Asp Ser Ser Ser Met Ser Asp Asp Asp Arg
545                 550                 555                 560 
Lys Glu Val Val Asn Ile Gln Thr Trp Ile Asn Lys Pro Asp Val Lys
                565                 570                 575     
His His Phe Pro Cys Lys Glu Val Lys Glu Ser Gly His Met Phe Pro
            580                 585                 590         
Ser His Leu Leu Val Thr Ala Thr His Met Tyr Cys Leu Arg Glu Ile
        595                 600                 605             
Val Ser Arg Lys Gly Leu Ala Tyr Ile Gln Ser Arg Gln Ala Leu Asn
    610                 615                 620                 
Ser Val Val Lys Ile Thr Ser Lys Lys Lys His Pro Glu Leu Ile Thr
625                 630                 635                 640 
Phe Lys Tyr Gly Asn Ser Ser Ala Ser Gly Ile Glu Ile Leu Ala Ile
                645                 650                 655     
Glu Arg Tyr Leu Ile Pro Asn Ala Gly Asp Ala Thr Lys Ala Ile Lys
            660                 665                 670         
Gln Gln Ile Met Lys Val Leu Asp Ala Leu Glu Ser
        675                 680                 


<210> 6102
<211> 587
<212> PRT
<213> Homo sapiens

<400> 6102
Met Pro Thr Ala Leu Cys Pro Arg Val Leu Ala Pro Lys Glu Ser Glu
 1               5                  10                  15      
Glu Pro Arg Lys Met Arg Ser Pro Pro Gly Glu Asn Pro Ser Pro Gln
            20                  25                  30          
Gly Glu Leu Pro Ser Pro Glu Ser Ser Arg Arg Leu Phe Arg Arg Phe
        35                  40                  45              
Arg Tyr Gln Glu Ala Ala Gly Pro Arg Glu Ala Leu Gln Arg Leu Trp
    50                  55                  60                  
Asp Leu Cys Gly Gly Trp Leu Arg Pro Glu Arg His Thr Lys Glu Gln
65                  70                  75                  80  
Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Ala Ile Leu Pro Arg
                85                  90                  95      
Glu Ile Gln Ser Trp Val Arg Ala Gln Glu Pro Glu Ser Gly Glu Gln
            100                 105                 110         
Ala Val Ala Ala Val Glu Ala Leu Glu Arg Glu Pro Gly Arg Pro Trp
        115                 120                 125             
Gln Trp Leu Lys His Cys Glu Asp Pro Val Val Ile Asp Asp Gly Asp
    130                 135                 140                 
Ser Pro Leu Asp Gln Glu Gln Glu Gln Leu Pro Val Glu Pro His Ser
145                 150                 155                 160 
Asp Leu Ala Lys Asn Gln Asp Ala Gln Pro Ile Thr Leu Ala Gln Cys
                165                 170                 175     
Leu Gly Leu Pro Ser Arg Pro Pro Ser Gln Leu Ser Gly Asp Pro Val
            180                 185                 190         
Leu Gln Asp Ala Phe Leu Leu Gln Glu Glu Asn Val Arg Asp Thr Gln
        195                 200                 205             
Gln Val Thr Thr Leu Gln Leu Pro Pro Ser Arg Val Ser Pro Phe Lys
    210                 215                 220                 
Asp Met Ile Leu Cys Phe Ser Glu Glu Asp Trp Ser Leu Leu Asp Pro
225                 230                 235                 240 
Ala Gln Thr Gly Phe Tyr Gly Glu Phe Ile Ile Gly Glu Asp Tyr Gly
                245                 250                 255     
Val Ser Met Pro Pro Asn Asp Leu Ala Ala Gln Pro Asp Leu Ser Gln
            260                 265                 270         
Gly Glu Glu Asn Glu Pro Arg Val Pro Glu Leu Gln Asp Leu Gln Gly
        275                 280                 285             
Lys Glu Val Pro Gln Val Ser Tyr Leu Asp Ser Pro Ser Leu Gln Pro
    290                 295                 300                 
Phe Gln Val Glu Glu Arg Arg Lys Arg Glu Glu Leu Gln Val Pro Glu
305                 310                 315                 320 
Phe Gln Ala Cys Pro Gln Thr Val Val Pro Gln Asn Thr Tyr Pro Ala
                325                 330                 335     
Gly Gly Asn Pro Arg Ser Leu Glu Asn Ser Leu Asp Glu Glu Val Thr
            340                 345                 350         
Ile Glu Ile Val Leu Ser Ser Ser Gly Asp Glu Asp Ser Gln His Gly
        355                 360                 365             
Pro Tyr Cys Thr Glu Glu Leu Gly Ser Pro Thr Glu Lys Gln Arg Ser
    370                 375                 380                 
Leu Pro Ala Ser His Arg Ser Ser Thr Glu Ala Gly Gly Glu Val Gln
385                 390                 395                 400 
Thr Ser Lys Lys Ser Tyr Val Cys Pro Asn Cys Gly Lys Ile Phe Arg
                405                 410                 415     
Trp Arg Val Asn Phe Ile Arg His Leu Arg Ser Arg Arg Glu Gln Glu
            420                 425                 430         
Lys Pro His Glu Cys Ser Val Cys Gly Glu Leu Phe Ser Asp Ser Glu
        435                 440                 445             
Asp Leu Asp Gly His Leu Glu Ser His Glu Ala Gln Lys Pro Tyr Arg
    450                 455                 460                 
Cys Gly Ala Cys Gly Lys Ser Phe Arg Leu Asn Ser His Leu Leu Ser
465                 470                 475                 480 
His Arg Arg Ile His Leu Gln Pro Asp Arg Leu Gln Pro Val Glu Lys
                485                 490                 495     
Arg Glu Gln Ala Ala Ser Glu Asp Ala Asp Lys Gly Pro Lys Glu Pro
            500                 505                 510         
Leu Glu Asn Gly Lys Ala Lys Leu Ser Phe Gln Cys Cys Glu Cys Gly
        515                 520                 525             
Lys Ala Phe Gln Arg His Asp His Leu Ala Arg His Arg Ser His Phe
    530                 535                 540                 
His Leu Lys Asp Lys Ala Arg Pro Phe Gln Cys Arg Tyr Cys Val Lys
545                 550                 555                 560 
Ser Phe Thr Gln Asn Tyr Asp Leu Leu Arg His Glu Arg Leu His Met
                565                 570                 575     
Lys Arg Arg Ser Lys Gln Ala Leu Asn Ser Tyr
            580                 585         


<210> 6103
<211> 671
<212> PRT
<213> Homo sapiens

<400> 6103
Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu
 1               5                  10                  15      
Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser
            20                  25                  30          
Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser
        35                  40                  45              
Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Asn Gly Gly His
    50                  55                  60                  
Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met
65                  70                  75                  80  
Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val
                85                  90                  95      
Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr
            100                 105                 110         
Gly Arg Glu Ser Asn Leu Gln Gly Cys His Gln Gln Ser Leu Leu Gly
        115                 120                 125             
Gly Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro
    130                 135                 140                 
Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Pro Arg Arg Arg Pro
145                 150                 155                 160 
Leu His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val
                165                 170                 175     
Pro Pro Gly Leu Pro Ser Ser Val Tyr Ala Pro Ser Ala Ser Thr Ala
            180                 185                 190         
Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Thr
        195                 200                 205             
Ser Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser
    210                 215                 220                 
Asp Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Ala Gly
225                 230                 235                 240 
Met Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser
                245                 250                 255     
Leu His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp
            260                 265                 270         
Ile Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr
        275                 280                 285             
Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp
    290                 295                 300                 
Ser Ile Met Ala Asn Arg Gly Ser Gly Ala Ala Gly Ser Ser Gln Thr
305                 310                 315                 320 
Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His
                325                 330                 335     
Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro
            340                 345                 350         
Pro Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln
        355                 360                 365             
Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser
    370                 375                 380                 
Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu
385                 390                 395                 400 
Arg Asn His Ala Val Gly Pro Ser Thr Ala Met Pro Gly Gly His Gly
                405                 410                 415     
Asp Met His Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Gly
            420                 425                 430         
Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser
        435                 440                 445             
Leu Met Val Gly Thr His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser
    450                 455                 460                 
His Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln
465                 470                 475                 480 
Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly
                485                 490                 495     
Met Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu
            500                 505                 510         
Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser
        515                 520                 525             
Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile
    530                 535                 540                 
Thr Arg Ser Arg Ser Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu
545                 550                 555                 560 
Gln Lys Ala Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg
                565                 570                 575     
Glu Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly
            580                 585                 590         
Arg Met Val Gln Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu
        595                 600                 605             
Leu Ile Leu His Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln
    610                 615                 620                 
Val Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg
625                 630                 635                 640 
Glu Glu Glu Lys Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly
                645                 650                 655     
Pro His Pro Gly Met Gly Asp Ala Ser Asn His Met Gly Gln Met
            660                 665                 670     


<210> 6104
<211> 667
<212> PRT
<213> Homo sapiens

<400> 6104
Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu
 1               5                  10                  15      
Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser
            20                  25                  30          
Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser
        35                  40                  45              
Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Asn Gly Gly His
    50                  55                  60                  
Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met
65                  70                  75                  80  
Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val
                85                  90                  95      
Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr
            100                 105                 110         
Gly Arg Glu Ser Asn Leu Gln Gly Cys His Gln Gln Ser Leu Leu Gly
        115                 120                 125             
Gly Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro
    130                 135                 140                 
Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Pro Arg Arg Arg Pro
145                 150                 155                 160 
Leu His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val
                165                 170                 175     
Pro Pro Gly Leu Pro Ser Ser Val Tyr Ala Pro Ser Ala Ser Thr Ala
            180                 185                 190         
Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Thr
        195                 200                 205             
Ser Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser
    210                 215                 220                 
Asp Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Ala Gly
225                 230                 235                 240 
Met Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser
                245                 250                 255     
Leu His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp
            260                 265                 270         
Ile Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr
        275                 280                 285             
Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp
    290                 295                 300                 
Ser Ile Met Ala Asn Arg Gly Ser Gly Ala Ala Gly Ser Ser Gln Thr
305                 310                 315                 320 
Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His
                325                 330                 335     
Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro
            340                 345                 350         
Pro Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln
        355                 360                 365             
Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser
    370                 375                 380                 
Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu
385                 390                 395                 400 
Arg Asn His Ala Val Gly Pro Ser Thr Ala Met Pro Gly Gly His Gly
                405                 410                 415     
Asp Met His Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Gly
            420                 425                 430         
Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser
        435                 440                 445             
Leu Met Val Gly Thr His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser
    450                 455                 460                 
His Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln
465                 470                 475                 480 
Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly
                485                 490                 495     
Met Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu
            500                 505                 510         
Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser
        515                 520                 525             
Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile
    530                 535                 540                 
Thr Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu Gln Lys Ala Glu
545                 550                 555                 560 
Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg Glu Arg Leu Arg
                565                 570                 575     
Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Val Gln
            580                 585                 590         
Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu Leu Ile Leu His
        595                 600                 605             
Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg
    610                 615                 620                 
Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys
625                 630                 635                 640 
Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly Pro His Pro Gly
                645                 650                 655     
Met Gly Asp Ala Ser Asn His Met Gly Gln Met
            660                 665         


<210> 6105
<211> 667
<212> PRT
<213> Homo sapiens

<400> 6105
Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu
 1               5                  10                  15      
Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser
            20                  25                  30          
Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser
        35                  40                  45              
Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Asn Gly Gly His
    50                  55                  60                  
Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met
65                  70                  75                  80  
Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val
                85                  90                  95      
Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr
            100                 105                 110         
Gly Arg Glu Ser Asn Leu Gln Gly Cys His Gln Gln Ser Leu Leu Gly
        115                 120                 125             
Gly Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro
    130                 135                 140                 
Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Pro Arg Arg Arg Pro
145                 150                 155                 160 
Leu His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val
                165                 170                 175     
Arg Asp Tyr Asn Gly Lys Ala Val Tyr Ala Pro Ser Ala Ser Thr Ala
            180                 185                 190         
Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Thr
        195                 200                 205             
Ser Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser
    210                 215                 220                 
Asp Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Ala Gly
225                 230                 235                 240 
Met Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser
                245                 250                 255     
Leu His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp
            260                 265                 270         
Ile Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr
        275                 280                 285             
Asn His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp
    290                 295                 300                 
Ser Ile Met Ala Asn Arg Gly Ser Gly Ala Ala Gly Ser Ser Gln Thr
305                 310                 315                 320 
Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His
                325                 330                 335     
Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro
            340                 345                 350         
Pro Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln
        355                 360                 365             
Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser
    370                 375                 380                 
Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu
385                 390                 395                 400 
Arg Asn His Ala Val Gly Pro Ser Thr Ala Met Pro Gly Gly His Gly
                405                 410                 415     
Asp Met His Gly Ile Ile Gly Pro Ser His Asn Gly Ala Met Gly Gly
            420                 425                 430         
Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu Ser Ala Asn Arg His Ser
        435                 440                 445             
Leu Met Val Gly Thr His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser
    450                 455                 460                 
His Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln
465                 470                 475                 480 
Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly
                485                 490                 495     
Met Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu
            500                 505                 510         
Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser
        515                 520                 525             
Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile
    530                 535                 540                 
Thr Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu Gln Lys Ala Glu
545                 550                 555                 560 
Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg Glu Arg Leu Arg
                565                 570                 575     
Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg Met Val Gln
            580                 585                 590         
Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu Leu Ile Leu His
        595                 600                 605             
Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln Val Arg Glu Arg
    610                 615                 620                 
Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys
625                 630                 635                 640 
Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly Pro His Pro Gly
                645                 650                 655     
Met Gly Asp Ala Ser Asn His Met Gly Gln Met
            660                 665         


<210> 6106
<211> 239
<212> PRT
<213> Homo sapiens

<400> 6106
Glu Ala Gly Ser Arg Pro Cys Pro Arg Ala Trp Glu Thr Leu Pro Arg
 1               5                  10                  15      
Pro Gly Arg Ala Arg Ala Pro Ala Ala Gly Gly Trp Ser Pro Leu Gly
            20                  25                  30          
His Cys Glu Pro Gly Val Ser Arg Ser Cys Arg Ala Ala Gln Ala Met
        35                  40                  45              
Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile Thr
    50                  55                  60                  
Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser Phe
65                  70                  75                  80  
Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala Pro
                85                  90                  95      
Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser Ser
            100                 105                 110         
His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu Asp
        115                 120                 125             
Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met
    130                 135                 140                 
Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln Leu
145                 150                 155                 160 
Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala Thr
                165                 170                 175     
Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu
            180                 185                 190         
Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser
        195                 200                 205             
His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn Phe
    210                 215                 220                 
Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn
225                 230                 235                 


<210> 6107
<211> 284
<212> PRT
<213> Homo sapiens

<400> 6107
Cys Ala Asp Pro Arg Cys Cys Cys Trp Glu Thr Val Glu Trp Leu Asn
 1               5                  10                  15      
Asp Pro Arg Gly Pro Trp Glu Ser Ser Glu Ala Leu Ser His Gln Val
            20                  25                  30          
Ala Gly Leu Ala Arg Val His Ser Phe Ile Gln Gln Ile Arg Met Cys
        35                  40                  45              
Ser Gly Ala Gly Val Met Met Ala Arg Trp Ala Ala Arg Gly Arg Ala
    50                  55                  60                  
Gly Trp Arg Ser Thr Val Arg Ile Leu Ser Pro Leu Gly His Cys Glu
65                  70                  75                  80  
Pro Gly Val Ser Arg Ser Cys Arg Ala Ala Gln Ala Met Asp Cys Glu
                85                  90                  95      
Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile Thr Asn Leu Leu
            100                 105                 110         
Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser Phe Arg Arg Glu
        115                 120                 125             
Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala Pro Gln Trp Glu
    130                 135                 140                 
Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser Ser His Ser Arg
145                 150                 155                 160 
Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu Asp Ile Ile Arg
                165                 170                 175     
Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met Asp Arg Ser
            180                 185                 190         
Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln Leu Arg Asn Thr
        195                 200                 205             
Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala Thr Ala Leu Glu
    210                 215                 220                 
Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu Lys Thr Met
225                 230                 235                 240 
Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser His Thr Pro
                245                 250                 255     
Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn Phe Ile Asn Gln
            260                 265                 270         
Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn
        275                 280                 


<210> 6108
<211> 441
<212> PRT
<213> Homo sapiens

<400> 6108
Met Lys Thr Leu Pro Leu His Ser His Cys Thr Glu Met Gln Arg Leu
 1               5                  10                  15      
Leu Pro Lys Leu Glu Met Leu Thr Leu Gly Ser Ser Phe Cys Ser Leu
            20                  25                  30          
Gln Gly Glu Phe Cys Gln Ala Met Asp Ser Phe Thr Thr Val Ser His
        35                  40                  45              
Val Gly Met Cys Glu Glu Thr Asp Ala Ser Phe Asn Val Phe Ser Pro
    50                  55                  60                  
Lys Phe Gln Phe Asp Arg Ser His Cys Gln Ser Leu Arg Phe His Gln
65                  70                  75                  80  
Asn Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser
                85                  90                  95      
Arg Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His
            100                 105                 110         
Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser
        115                 120                 125             
Asn Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg
    130                 135                 140                 
Tyr Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser
145                 150                 155                 160 
Phe Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile
                165                 170                 175     
Asn Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg
            180                 185                 190         
Lys Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys
        195                 200                 205             
Ser Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn
    210                 215                 220                 
Pro Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro
225                 230                 235                 240 
Gln Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp
                245                 250                 255     
Phe Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro
            260                 265                 270         
Arg Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe
        275                 280                 285             
Glu Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly
    290                 295                 300                 
Val Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu
305                 310                 315                 320 
His Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu
                325                 330                 335     
Lys Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys
            340                 345                 350         
Arg Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser
        355                 360                 365             
Pro Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg
    370                 375                 380                 
Ser Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu
385                 390                 395                 400 
Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro
                405                 410                 415     
Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp
            420                 425                 430         
Asp Ser Asp Ser Leu Gly Asp Ser Met
        435                 440     


<210> 6109
<211> 360
<212> PRT
<213> Homo sapiens

<400> 6109
Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg
 1               5                  10                  15      
Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser
            20                  25                  30          
Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn
        35                  40                  45              
Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr
    50                  55                  60                  
Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe
65                  70                  75                  80  
Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn
                85                  90                  95      
Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys
            100                 105                 110         
Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser
        115                 120                 125             
Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro
    130                 135                 140                 
Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln
145                 150                 155                 160 
Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe
                165                 170                 175     
Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg
            180                 185                 190         
Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu
        195                 200                 205             
Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val
    210                 215                 220                 
Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His
225                 230                 235                 240 
Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys
                245                 250                 255     
Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg
            260                 265                 270         
Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro
        275                 280                 285             
Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser
    290                 295                 300                 
Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu Ser
305                 310                 315                 320 
Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro Gly
                325                 330                 335     
Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp Asp
            340                 345                 350         
Ser Asp Ser Leu Gly Asp Ser Met
        355                 360 


<210> 6110
<211> 1272
<212> PRT
<213> Homo sapiens

<400> 6110
Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys
 1               5                  10                  15      
His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg
            20                  25                  30          
Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe
        35                  40                  45              
Asp Leu Phe Gly Glu Pro Tyr Lys Thr Asn Lys Gly Asp Ala Leu Ala
    50                  55                  60                  
Asn Arg Val Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys Asn Leu
65                  70                  75                  80  
Leu Thr Asn His Ser Asn Gln Asn His Leu Val Gly Ile Pro Lys Asn
                85                  90                  95      
Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro Ser Phe Phe Pro
            100                 105                 110         
Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp Asn Thr His Pro
        115                 120                 125             
Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu Asn Ser Thr Leu
    130                 135                 140                 
Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser Arg Asp Ser His
145                 150                 155                 160 
Asn Pro Ser Thr Val Leu Ala Ser Gln Ala Ser Gly Gln Pro Asn Lys
                165                 170                 175     
Met Gln Thr Leu Thr Gln Asp Gln Ser Gln Ala Lys Leu Glu Asp Phe
            180                 185                 190         
Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu Val Glu Glu Ser
        195                 200                 205             
Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser Ser Gly Glu Asp
    210                 215                 220                 
Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu Glu Ser Glu Phe
225                 230                 235                 240 
Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser Ser Leu Leu Ala
                245                 250                 255     
Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro Gly Leu Tyr Cys
            260                 265                 270         
Lys Thr Ser Met Gly Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met
        275                 280                 285             
Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Thr Leu Lys Pro Ser
    290                 295                 300                 
Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe Gly Thr Leu Leu
305                 310                 315                 320 
Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Thr Lys Leu Pro Lys Phe
                325                 330                 335     
Thr Ile Leu Gln Thr Ser Glu Val Ser Leu Pro Ser Asp Pro Ser Cys
            340                 345                 350         
Val Glu Glu Ile Leu Arg Glu Ser Gln His Leu Thr Pro Gly Phe Thr
        355                 360                 365             
Leu Gln Lys Trp Asn Asp Pro Thr Thr Arg Ala Ser Thr Lys Met Leu
    370                 375                 380                 
Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu Asp Asp Leu Glu Pro Val
385                 390                 395                 400 
Lys Thr Leu Thr Thr Gln Cys Thr Ala Thr Glu Leu Tyr Gln Ala Val
                405                 410                 415     
Glu Lys Ala Lys Pro Arg Asn Asn Pro Val Asn Pro Pro Leu Ala Thr
            420                 425                 430         
Pro Gln Pro Pro Pro Ala Val Gln Ala Ser Gly Gly Ser Gly Ser Ser
        435                 440                 445             
Ser Glu Ser Glu Ser Ser Ser Glu Ser Asp Ser Asp Thr Glu Ser Ser
    450                 455                 460                 
Thr Thr Asp Ser Glu Ser Asn Glu Ala Pro Arg Val Ala Thr Pro Glu
465                 470                 475                 480 
Pro Glu Pro Pro Ser Thr Asn Lys Trp Gln Leu Asp Lys Trp Leu Asn
                485                 490                 495     
Lys Val Thr Ser Gln Asn Lys Ser Phe Ile Cys Gly Pro Asn Glu Thr
            500                 505                 510         
Pro Met Glu Thr Ile Ser Leu Pro Pro Pro Ile Ile Gln Pro Met Glu
        515                 520                 525             
Val Gln Met Lys Val Lys Thr Asn Ala Ser Gln Val Pro Ala Glu Pro
    530                 535                 540                 
Lys Glu Arg Pro Leu Leu Ser Leu Ile Arg Glu Lys Ala Arg Pro Arg
545                 550                 555                 560 
Pro Thr Gln Lys Ile Pro Glu Thr Lys Ala Leu Lys His Lys Leu Ser
                565                 570                 575     
Thr Thr Ser Glu Thr Val Ser Gln Arg Thr Ile Gly Lys Lys Gln Pro
            580                 585                 590         
Lys Lys Val Glu Lys Asn Thr Ser Thr Asp Glu Phe Thr Trp Pro Lys
        595                 600                 605             
Pro Asn Ile Thr Ser Ser Thr Pro Lys Glu Lys Glu Ser Val Glu Leu
    610                 615                 620                 
His Asp Pro Pro Arg Gly Arg Asn Lys Ala Thr Ala His Lys Pro Ala
625                 630                 635                 640 
Pro Arg Lys Glu Pro Arg Pro Asn Ile Pro Leu Ala Pro Glu Lys Lys
                645                 650                 655     
Lys Tyr Arg Gly Pro Gly Lys Ile Val Pro Lys Ser Arg Glu Phe Ile
            660                 665                 670         
Glu Thr Asp Ser Ser Thr Ser Asp Ser Asn Thr Asp Gln Glu Glu Thr
        675                 680                 685             
Leu Gln Ile Lys Val Leu Pro Pro Cys Ile Ile Ser Gly Gly Asn Thr
    690                 695                 700                 
Ala Lys Ser Lys Glu Ile Cys Gly Ala Ser Leu Thr Leu Ser Thr Leu
705                 710                 715                 720 
Met Ser Ser Ser Gly Ser Asn Asn Asn Leu Ser Ile Ser Asn Glu Glu
                725                 730                 735     
Pro Thr Phe Ser Pro Ile Pro Val Met Gln Thr Glu Ile Leu Ser Pro
            740                 745                 750         
Leu Arg Asp His Glu Asn Leu Lys Asn Leu Trp Val Lys Ile Asp Leu
        755                 760                 765             
Asp Leu Leu Ser Arg Val Pro Gly His Ser Ser Leu His Ala Ala Pro
    770                 775                 780                 
Ala Lys Pro Asp His Lys Glu Thr Ala Thr Lys Pro Lys Arg Gln Thr
785                 790                 795                 800 
Ala Val Thr Ala Val Glu Lys Pro Ala Pro Lys Gly Lys Arg Lys His
                805                 810                 815     
Lys Pro Ile Glu Val Ala Glu Lys Ile Pro Glu Lys Lys Gln Arg Leu
            820                 825                 830         
Glu Glu Ala Thr Thr Ile Cys Leu Leu Pro Pro Cys Ile Ser Pro Ala
        835                 840                 845             
Pro Pro His Lys Pro Pro Asn Thr Arg Glu Asn Asn Ser Ser Arg Arg
    850                 855                 860                 
Ala Asn Arg Arg Lys Glu Glu Lys Leu Phe Pro Pro Pro Leu Ser Pro
865                 870                 875                 880 
Leu Pro Glu Asp Pro Pro Arg Arg Arg Asn Val Ser Gly Asn Asn Gly
                885                 890                 895     
Pro Phe Gly Gln Asp Lys Asn Ile Ala Met Thr Gly Gln Ile Thr Ser
            900                 905                 910         
Thr Lys Pro Lys Arg Thr Glu Gly Lys Phe Cys Ala Thr Phe Lys Gly
        915                 920                 925             
Ile Ser Val Asn Glu Gly Asp Thr Pro Lys Lys Ala Ser Ser Ala Thr
    930                 935                 940                 
Ile Thr Val Thr Asn Thr Ala Ile Ala Thr Ala Thr Val Thr Ala Thr
945                 950                 955                 960 
Ala Ile Val Thr Thr Thr Val Thr Ala Thr Ala Thr Ala Thr Ala Thr
                965                 970                 975     
Thr Thr Thr Thr Thr Thr Thr Ile Ser Thr Ile Thr Ser Thr Ile Thr
            980                 985                 990         
Thr Gly Leu Met Asp Ser Ser His Leu Glu Met Thr Ser Trp Ala Ala
        995                 1000                1005            
Leu Pro Leu Leu Ser Ser Ser Ser Thr Asn Val Arg Arg Pro Lys Leu
    1010                1015                1020                
Thr Phe Asp Asp Ser Val His Asn Ala Asp Tyr Tyr Met Gln Glu Ala
1025                1030                1035                1040
Lys Lys Leu Lys His Lys Ala Asp Ala Leu Phe Glu Lys Phe Gly Lys
                1045                1050                1055    
Ala Val Asn Tyr Ala Asp Ala Ala Leu Ser Phe Thr Glu Cys Gly Asn
            1060                1065                1070        
Ala Met Glu Arg Asp Pro Leu Glu Ala Lys Ser Pro Tyr Thr Met Tyr
        1075                1080                1085            
Ser Glu Thr Val Glu Leu Leu Arg Tyr Ala Met Arg Leu Lys Asn Phe
    1090                1095                1100                
Ala Ser Pro Leu Ala Ser Asp Gly Asp Lys Lys Leu Ala Val Leu Cys
1105                1110                1115                1120
Tyr Arg Cys Leu Ser Leu Leu Tyr Leu Arg Met Phe Lys Leu Lys Lys
                1125                1130                1135    
Asp His Ala Met Lys Tyr Ser Arg Ser Leu Met Glu Tyr Phe Lys Gln
            1140                1145                1150        
Asn Ala Ser Lys Val Ala Gln Ile Pro Ser Pro Trp Val Ser Asn Gly
        1155                1160                1165            
Lys Asn Thr Pro Ser Pro Val Ser Leu Asn Asn Val Ser Pro Ile Asn
    1170                1175                1180                
Ala Met Gly Asn Cys Asn Asn Gly Pro Val Thr Ile Pro Gln Arg Ile
1185                1190                1195                1200
His His Met Ala Ala Ser His Val Asn Ile Thr Ser Asn Val Leu Arg
                1205                1210                1215    
Gly Tyr Glu His Trp Asp Met Ala Asp Lys Leu Thr Arg Glu Asn Lys
            1220                1225                1230        
Glu Phe Phe Gly Asp Leu Asp Thr Leu Met Gly Pro Leu Thr Gln His
        1235                1240                1245            
Ser Ser Met Thr Asn Leu Val Arg Tyr Val Arg Gln Gly Leu Cys Trp
    1250                1255                1260                
Leu Arg Ile Asp Ala His Leu Leu
1265                1270        


<210> 6111
<211> 1311
<212> PRT
<213> Homo sapiens

<400> 6111
Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys
 1               5                  10                  15      
His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg
            20                  25                  30          
Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe
        35                  40                  45              
Asp Leu Phe Gly Glu Pro Tyr Lys Val Ala Glu Tyr Thr Asn Lys Gly
    50                  55                  60                  
Asp Ala Leu Ala Asn Arg Val Gln Asn Thr Leu Gly Asn Tyr Asp Glu
65                  70                  75                  80  
Met Lys Asn Leu Leu Thr Asn His Ser Asn Gln Asn His Leu Val Gly
                85                  90                  95      
Ile Pro Lys Asn Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro
            100                 105                 110         
Ser Phe Phe Pro Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp
        115                 120                 125             
Asn Thr His Pro Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu
    130                 135                 140                 
Asn Ser Thr Leu Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser
145                 150                 155                 160 
Arg Asp Ser His Asn Pro Ser Thr Val Leu Ala Ser Gln Ala Ser Gly
                165                 170                 175     
Gln Pro Asn Lys Met Gln Thr Leu Thr Gln Asp Gln Ser Gln Ala Lys
            180                 185                 190         
Leu Glu Asp Phe Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu
        195                 200                 205             
Val Glu Glu Ser Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser
    210                 215                 220                 
Ser Gly Glu Asp Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu
225                 230                 235                 240 
Glu Ser Glu Phe Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser
                245                 250                 255     
Ser Leu Leu Ala Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro
            260                 265                 270         
Gly Leu Tyr Cys Lys Thr Ser Met Gly Gln Gln Lys Pro Thr Ala Tyr
        275                 280                 285             
Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Thr
    290                 295                 300                 
Leu Lys Pro Ser Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe
305                 310                 315                 320 
Gly Thr Leu Leu Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Thr Lys
                325                 330                 335     
Leu Pro Lys Phe Thr Ile Leu Gln Thr Ser Glu Val Ser Leu Pro Ser
            340                 345                 350         
Asp Pro Ser Cys Val Glu Glu Ile Leu Arg Glu Met Thr His Ser Trp
        355                 360                 365             
Pro Thr Pro Leu Thr Ser Met His Thr Ala Gly His Ser Glu Gln Ser
    370                 375                 380                 
Thr Phe Ser Ile Pro Gly Gln Glu Ser Gln His Leu Thr Pro Gly Phe
385                 390                 395                 400 
Thr Leu Gln Lys Trp Asn Asp Pro Thr Thr Arg Ala Ser Thr Lys Ser
                405                 410                 415     
Val Ser Phe Lys Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp
            420                 425                 430         
Glu Asp Asp Leu Glu Pro Val Lys Thr Leu Thr Thr Gln Cys Thr Ala
        435                 440                 445             
Thr Glu Leu Tyr Gln Ala Val Glu Lys Ala Lys Pro Arg Asn Asn Pro
    450                 455                 460                 
Val Asn Pro Pro Leu Ala Thr Pro Gln Pro Pro Pro Ala Val Gln Ala
465                 470                 475                 480 
Ser Gly Gly Ser Gly Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu Ser
                485                 490                 495     
Asp Ser Asp Thr Glu Ser Ser Thr Thr Asp Ser Glu Ser Asn Glu Ala
            500                 505                 510         
Pro Arg Val Ala Thr Pro Glu Pro Glu Pro Pro Ser Thr Asn Lys Trp
        515                 520                 525             
Gln Leu Asp Lys Trp Leu Asn Lys Val Thr Ser Gln Asn Lys Ser Phe
    530                 535                 540                 
Ile Cys Gly Pro Asn Glu Thr Pro Met Glu Thr Ile Ser Leu Pro Pro
545                 550                 555                 560 
Pro Ile Ile Gln Pro Met Glu Val Gln Met Lys Val Lys Thr Asn Ala
                565                 570                 575     
Ser Gln Val Pro Ala Glu Pro Lys Glu Arg Pro Leu Leu Ser Leu Ile
            580                 585                 590         
Arg Glu Lys Ala Arg Pro Arg Pro Thr Gln Lys Ile Pro Glu Thr Lys
        595                 600                 605             
Ala Leu Lys His Lys Leu Ser Thr Thr Ser Glu Thr Val Ser Gln Arg
    610                 615                 620                 
Thr Ile Gly Lys Lys Gln Pro Lys Lys Val Glu Lys Asn Thr Ser Thr
625                 630                 635                 640 
Asp Glu Phe Thr Trp Pro Lys Pro Asn Ile Thr Ser Ser Thr Pro Lys
                645                 650                 655     
Glu Lys Glu Ser Val Glu Leu His Asp Pro Pro Arg Gly Arg Asn Lys
            660                 665                 670         
Ala Thr Ala His Lys Pro Ala Pro Arg Lys Glu Pro Arg Pro Asn Ile
        675                 680                 685             
Pro Leu Ala Pro Glu Lys Lys Lys Tyr Arg Gly Pro Gly Lys Ile Val
    690                 695                 700                 
Pro Lys Ser Arg Glu Phe Ile Glu Thr Asp Ser Ser Thr Ser Asp Ser
705                 710                 715                 720 
Asn Thr Asp Gln Glu Glu Thr Leu Gln Ile Lys Val Leu Pro Pro Cys
                725                 730                 735     
Ile Ile Ser Gly Gly Asn Thr Ala Lys Ser Lys Glu Ile Cys Gly Ala
            740                 745                 750         
Ser Leu Thr Leu Ser Thr Leu Met Ser Ser Ser Gly Ser Asn Asn Asn
        755                 760                 765             
Leu Ser Ile Ser Asn Glu Glu Pro Thr Phe Ser Pro Ile Pro Val Met
    770                 775                 780                 
Gln Thr Glu Ile Leu Ser Pro Leu Arg Asp His Glu Asn Leu Lys Asn
785                 790                 795                 800 
Leu Trp Val Lys Ile Asp Leu Asp Leu Leu Ser Arg Val Pro Gly His
                805                 810                 815     
Ser Ser Leu His Ala Ala Pro Ala Lys Pro Asp His Lys Glu Thr Ala
            820                 825                 830         
Thr Lys Pro Lys Arg Gln Thr Ala Val Thr Ala Val Glu Lys Pro Ala
        835                 840                 845             
Pro Lys Gly Lys Arg Lys His Lys Pro Ile Glu Val Ala Glu Lys Ile
    850                 855                 860                 
Pro Glu Lys Lys Gln Arg Leu Glu Glu Ala Thr Thr Ile Cys Leu Leu
865                 870                 875                 880 
Pro Pro Cys Ile Ser Pro Ala Pro Pro His Lys Pro Pro Asn Thr Arg
                885                 890                 895     
Glu Asn Asn Ser Ser Arg Arg Ala Asn Arg Arg Lys Glu Glu Lys Leu
            900                 905                 910         
Phe Pro Pro Pro Leu Ser Pro Leu Pro Glu Asp Pro Pro Arg Arg Arg
        915                 920                 925             
Asn Val Ser Gly Asn Asn Gly Pro Phe Gly Gln Asp Lys Asn Ile Ala
    930                 935                 940                 
Met Thr Gly Gln Ile Thr Ser Thr Lys Pro Lys Arg Thr Glu Gly Lys
945                 950                 955                 960 
Phe Cys Ala Thr Phe Lys Gly Ile Ser Val Asn Glu Gly Asp Thr Pro
                965                 970                 975     
Lys Lys Ala Ser Ser Ala Thr Ile Thr Val Thr Asn Thr Ala Ile Ala
            980                 985                 990         
Thr Ala Thr Val Thr Ala Thr Ala Ile Val Thr Thr Thr Val Thr Ala
        995                 1000                1005            
Thr Ala Thr Ala Thr Ala Thr Thr Thr Thr Thr Thr Thr Thr Ile Ser
    1010                1015                1020                
Thr Ile Thr Ser Thr Ile Thr Thr Gly Leu Met Asp Ser Ser His Leu
1025                1030                1035                1040
Glu Met Thr Ser Trp Ala Ala Leu Pro Leu Leu Ser Ser Ser Ser Thr
                1045                1050                1055    
Asn Val Arg Arg Pro Lys Leu Thr Phe Asp Asp Ser Val His Asn Ala
            1060                1065                1070        
Asp Tyr Tyr Met Gln Glu Ala Lys Lys Leu Lys His Lys Ala Asp Ala
        1075                1080                1085            
Leu Phe Glu Lys Phe Gly Lys Ala Val Asn Tyr Ala Asp Ala Ala Leu
    1090                1095                1100                
Ser Phe Thr Glu Cys Gly Asn Ala Met Glu Arg Asp Pro Leu Glu Ala
1105                1110                1115                1120
Lys Ser Pro Tyr Thr Met Tyr Ser Glu Thr Val Glu Leu Leu Arg Tyr
                1125                1130                1135    
Ala Met Arg Leu Lys Asn Phe Ala Ser Pro Leu Ala Ser Asp Gly Asp
            1140                1145                1150        
Lys Lys Leu Ala Val Leu Cys Tyr Arg Cys Leu Ser Leu Leu Tyr Leu
        1155                1160                1165            
Arg Met Phe Lys Leu Lys Lys Asp His Ala Met Lys Tyr Ser Arg Ser
    1170                1175                1180                
Leu Met Glu Tyr Phe Lys Gln Asn Ala Ser Lys Val Ala Gln Ile Pro
1185                1190                1195                1200
Ser Pro Trp Val Ser Asn Gly Lys Asn Thr Pro Ser Pro Val Ser Leu
                1205                1210                1215    
Asn Asn Val Ser Pro Ile Asn Ala Met Gly Asn Cys Asn Asn Gly Pro
            1220                1225                1230        
Val Thr Ile Pro Gln Arg Ile His His Met Ala Ala Ser His Val Asn
        1235                1240                1245            
Ile Thr Ser Asn Val Leu Arg Gly Tyr Glu His Trp Asp Met Ala Asp
    1250                1255                1260                
Lys Leu Thr Arg Glu Asn Lys Glu Phe Phe Gly Asp Leu Asp Thr Leu
1265                1270                1275                1280
Met Gly Pro Leu Thr Gln His Ser Ser Met Thr Asn Leu Val Arg Tyr
                1285                1290                1295    
Val Arg Gln Gly Leu Cys Trp Leu Arg Ile Asp Ala His Leu Leu
            1300                1305                1310    


<210> 6112
<211> 1276
<212> PRT
<213> Homo sapiens

<400> 6112
Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys
 1               5                  10                  15      
His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg
            20                  25                  30          
Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe
        35                  40                  45              
Asp Leu Phe Gly Glu Pro Tyr Lys Thr Asn Lys Gly Asp Ala Leu Ala
    50                  55                  60                  
Asn Arg Val Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys Asn Leu
65                  70                  75                  80  
Leu Thr Asn His Ser Asn Gln Asn His Leu Val Gly Ile Pro Lys Asn
                85                  90                  95      
Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro Ser Phe Phe Pro
            100                 105                 110         
Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp Asn Thr His Pro
        115                 120                 125             
Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu Asn Ser Thr Leu
    130                 135                 140                 
Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser Arg Asp Ser His
145                 150                 155                 160 
Asn Pro Ser Thr Val Leu Ala Ser Gln Ala Ser Gly Gln Pro Asn Lys
                165                 170                 175     
Met Gln Thr Leu Thr Gln Asp Gln Ser Gln Ala Lys Leu Glu Asp Phe
            180                 185                 190         
Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu Val Glu Glu Ser
        195                 200                 205             
Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser Ser Gly Glu Asp
    210                 215                 220                 
Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu Glu Ser Glu Phe
225                 230                 235                 240 
Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser Ser Leu Leu Ala
                245                 250                 255     
Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro Gly Leu Tyr Cys
            260                 265                 270         
Lys Thr Ser Met Gly Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met
        275                 280                 285             
Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Thr Leu Lys Pro Ser
    290                 295                 300                 
Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe Gly Thr Leu Leu
305                 310                 315                 320 
Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Thr Lys Leu Pro Lys Phe
                325                 330                 335     
Thr Ile Leu Gln Thr Ser Glu Val Ser Leu Pro Ser Asp Pro Ser Cys
            340                 345                 350         
Val Glu Glu Ile Leu Arg Glu Ser Gln His Leu Thr Pro Gly Phe Thr
        355                 360                 365             
Leu Gln Lys Trp Asn Asp Pro Thr Thr Arg Ala Ser Thr Lys Ser Val
    370                 375                 380                 
Ser Phe Lys Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu
385                 390                 395                 400 
Asp Asp Leu Glu Pro Val Lys Thr Leu Thr Thr Gln Cys Thr Ala Thr
                405                 410                 415     
Glu Leu Tyr Gln Ala Val Glu Lys Ala Lys Pro Arg Asn Asn Pro Val
            420                 425                 430         
Asn Pro Pro Leu Ala Thr Pro Gln Pro Pro Pro Ala Val Gln Ala Ser
        435                 440                 445             
Gly Gly Ser Gly Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu Ser Asp
    450                 455                 460                 
Ser Asp Thr Glu Ser Ser Thr Thr Asp Ser Glu Ser Asn Glu Ala Pro
465                 470                 475                 480 
Arg Val Ala Thr Pro Glu Pro Glu Pro Pro Ser Thr Asn Lys Trp Gln
                485                 490                 495     
Leu Asp Lys Trp Leu Asn Lys Val Thr Ser Gln Asn Lys Ser Phe Ile
            500                 505                 510         
Cys Gly Pro Asn Glu Thr Pro Met Glu Thr Ile Ser Leu Pro Pro Pro
        515                 520                 525             
Ile Ile Gln Pro Met Glu Val Gln Met Lys Val Lys Thr Asn Ala Ser
    530                 535                 540                 
Gln Val Pro Ala Glu Pro Lys Glu Arg Pro Leu Leu Ser Leu Ile Arg
545                 550                 555                 560 
Glu Lys Ala Arg Pro Arg Pro Thr Gln Lys Ile Pro Glu Thr Lys Ala
                565                 570                 575     
Leu Lys His Lys Leu Ser Thr Thr Ser Glu Thr Val Ser Gln Arg Thr
            580                 585                 590         
Ile Gly Lys Lys Gln Pro Lys Lys Val Glu Lys Asn Thr Ser Thr Asp
        595                 600                 605             
Glu Phe Thr Trp Pro Lys Pro Asn Ile Thr Ser Ser Thr Pro Lys Glu
    610                 615                 620                 
Lys Glu Ser Val Glu Leu His Asp Pro Pro Arg Gly Arg Asn Lys Ala
625                 630                 635                 640 
Thr Ala His Lys Pro Ala Pro Arg Lys Glu Pro Arg Pro Asn Ile Pro
                645                 650                 655     
Leu Ala Pro Glu Lys Lys Lys Tyr Arg Gly Pro Gly Lys Ile Val Pro
            660                 665                 670         
Lys Ser Arg Glu Phe Ile Glu Thr Asp Ser Ser Thr Ser Asp Ser Asn
        675                 680                 685             
Thr Asp Gln Glu Glu Thr Leu Gln Ile Lys Val Leu Pro Pro Cys Ile
    690                 695                 700                 
Ile Ser Gly Gly Asn Thr Ala Lys Ser Lys Glu Ile Cys Gly Ala Ser
705                 710                 715                 720 
Leu Thr Leu Ser Thr Leu Met Ser Ser Ser Gly Ser Asn Asn Asn Leu
                725                 730                 735     
Ser Ile Ser Asn Glu Glu Pro Thr Phe Ser Pro Ile Pro Val Met Gln
            740                 745                 750         
Thr Glu Ile Leu Ser Pro Leu Arg Asp His Glu Asn Leu Lys Asn Leu
        755                 760                 765             
Trp Val Lys Ile Asp Leu Asp Leu Leu Ser Arg Val Pro Gly His Ser
    770                 775                 780                 
Ser Leu His Ala Ala Pro Ala Lys Pro Asp His Lys Glu Thr Ala Thr
785                 790                 795                 800 
Lys Pro Lys Arg Gln Thr Ala Val Thr Ala Val Glu Lys Pro Ala Pro
                805                 810                 815     
Lys Gly Lys Arg Lys His Lys Pro Ile Glu Val Ala Glu Lys Ile Pro
            820                 825                 830         
Glu Lys Lys Gln Arg Leu Glu Glu Ala Thr Thr Ile Cys Leu Leu Pro
        835                 840                 845             
Pro Cys Ile Ser Pro Ala Pro Pro His Lys Pro Pro Asn Thr Arg Glu
    850                 855                 860                 
Asn Asn Ser Ser Arg Arg Ala Asn Arg Arg Lys Glu Glu Lys Leu Phe
865                 870                 875                 880 
Pro Pro Pro Leu Ser Pro Leu Pro Glu Asp Pro Pro Arg Arg Arg Asn
                885                 890                 895     
Val Ser Gly Asn Asn Gly Pro Phe Gly Gln Asp Lys Asn Ile Ala Met
            900                 905                 910         
Thr Gly Gln Ile Thr Ser Thr Lys Pro Lys Arg Thr Glu Gly Lys Phe
        915                 920                 925             
Cys Ala Thr Phe Lys Gly Ile Ser Glu Gly Asp Thr Pro Lys Lys Ala
    930                 935                 940                 
Ser Ser Ala Thr Ile Thr Val Thr Asn Thr Ala Ile Ala Thr Ala Thr
945                 950                 955                 960 
Val Thr Ala Thr Ala Ile Val Thr Thr Thr Val Thr Ala Thr Ala Thr
                965                 970                 975     
Ala Thr Ala Thr Thr Thr Thr Thr Thr Thr Thr Ile Ser Thr Ile Thr
            980                 985                 990         
Ser Thr Ile Thr Thr Gly Leu Met Asp Ser Ser His Leu Glu Met Thr
        995                 1000                1005            
Ser Trp Ala Ala Leu Pro Leu Leu Ser Ser Ser Ser Thr Asn Val Arg
    1010                1015                1020                
Arg Pro Lys Leu Thr Phe Asp Asp Ser Val His Asn Ala Asp Tyr Tyr
1025                1030                1035                1040
Met Gln Glu Ala Lys Lys Leu Lys His Lys Ala Asp Ala Leu Phe Glu
                1045                1050                1055    
Lys Phe Gly Lys Ala Val Asn Tyr Ala Asp Ala Ala Leu Ser Phe Thr
            1060                1065                1070        
Glu Cys Gly Asn Ala Met Glu Arg Asp Pro Leu Glu Ala Lys Ser Pro
        1075                1080                1085            
Tyr Thr Met Tyr Ser Glu Thr Val Glu Leu Leu Arg Tyr Ala Met Arg
    1090                1095                1100                
Leu Lys Asn Phe Ala Ser Pro Leu Ala Ser Asp Gly Asp Lys Lys Leu
1105                1110                1115                1120
Ala Val Leu Cys Tyr Arg Cys Leu Ser Leu Leu Tyr Leu Arg Met Phe
                1125                1130                1135    
Lys Leu Lys Lys Asp His Ala Met Lys Tyr Ser Arg Ser Leu Met Glu
            1140                1145                1150        
Tyr Phe Lys Gln Asn Ala Ser Lys Val Ala Gln Ile Pro Ser Pro Trp
        1155                1160                1165            
Val Ser Asn Gly Lys Asn Thr Pro Ser Pro Val Ser Leu Asn Asn Val
    1170                1175                1180                
Ser Pro Ile Asn Ala Met Gly Asn Cys Asn Asn Gly Pro Val Thr Ile
1185                1190                1195                1200
Pro Gln Arg Ile His His Met Ala Ala Ser His Val Asn Ile Thr Ser
                1205                1210                1215    
Asn Val Leu Arg Gly Tyr Glu His Trp Asp Met Ala Asp Lys Leu Thr
            1220                1225                1230        
Arg Glu Asn Lys Glu Phe Phe Gly Asp Leu Asp Thr Leu Met Gly Pro
        1235                1240                1245            
Leu Thr Gln His Ser Ser Met Thr Asn Leu Val Arg Tyr Val Arg Gln
    1250                1255                1260                
Gly Leu Cys Trp Leu Arg Ile Asp Ala His Leu Leu
1265                1270                1275    


<210> 6113
<211> 747
<212> PRT
<213> Homo sapiens

<400> 6113
Met Phe Gly Gly Pro Gly Pro Gly Val Leu Gly Ala Gln Gly Met Ala
 1               5                  10                  15      
Gly Pro Leu Arg Gly Arg Val Glu Glu Leu Lys Leu Pro Trp Trp Arg
            20                  25                  30          
Glu Ser Ser Pro Leu Val Leu Arg His Ser Glu Ala Ala Arg Leu Ala
        35                  40                  45              
Ala Asp Ala Leu Leu Glu Arg Gly Glu Ala Ala Tyr Leu Arg Val Ile
    50                  55                  60                  
Ser Glu Glu Arg Glu Leu Pro Phe Leu Ser Ala Leu Asp Val Asp Tyr
65                  70                  75                  80  
Met Thr Ser His Val Arg Gly Gly Pro Glu Leu Ser Glu Ala Gln Gly
                85                  90                  95      
Gln Glu Ala Ser Gly Pro Asp Arg Leu Ser Leu Leu Ser Glu Val Thr
            100                 105                 110         
Ser Gly Thr Tyr Phe Pro Met Ala Ser Asp Ile Asp Pro Pro Asp Leu
        115                 120                 125             
Asp Leu Gly Trp Pro Glu Val Pro Gln Ala Thr Gly Phe Ser Pro Thr
    130                 135                 140                 
Gln Ala Val Val His Phe Gln Arg Asp Lys Ala Lys Asn Ile Lys Asp
145                 150                 155                 160 
Leu Leu Arg Phe Leu Phe Ser Gln Ala His Thr Val Val Ala Val Val
                165                 170                 175     
Met Asp Ile Phe Thr Asp Met Glu Leu Leu Cys Asp Leu Met Glu Ala
            180                 185                 190         
Ser Ser Arg Arg Gly Val Pro Val Tyr Leu Leu Leu Ala Gln Glu His
        195                 200                 205             
Leu Arg His Phe Leu Glu Met Cys Tyr Lys Met Asp Leu Asn Gly Glu
    210                 215                 220                 
His Leu Pro Asn Met Arg Val Arg Ser Thr Cys Gly Asp Thr Tyr Cys
225                 230                 235                 240 
Ser Lys Ala Gly Arg Arg Phe Thr Gly Gln Ala Leu Glu Lys Phe Val
                245                 250                 255     
Leu Ile Asp Cys Glu Gln Val Val Ala Gly Ser Tyr Ser Phe Thr Trp
            260                 265                 270         
Leu Cys Ser Gln Ala His Thr Ser Met Val Leu Gln Leu Arg Gly Arg
        275                 280                 285             
Ile Val Glu Asp Phe Asp Arg Glu Phe Arg Cys Leu Tyr Ala Glu Ser
    290                 295                 300                 
Gln Pro Val Glu Gly Phe Cys Gly Gly Glu Asp Pro Leu Ser Pro Arg
305                 310                 315                 320 
Ala Leu Arg Pro Pro Pro Val Ala Leu Ala Phe Arg Pro Asp Val Pro
                325                 330                 335     
Ser Pro Thr Ser Ser Leu Pro Ser Ser Thr Ser Leu Ser Ser Ile Lys
            340                 345                 350         
Gln Ser Pro Leu Met Gly Arg Ser Ser Tyr Leu Ala Leu Pro Gly Gly
        355                 360                 365             
Gly Asp Cys Ser Asp Thr Gly Val Val Ser Ser Ser Leu Gly Pro Ala
    370                 375                 380                 
Arg Arg Glu Ala Ser Gly Gln Pro Ser Leu His Arg Gln Leu Ser Asp
385                 390                 395                 400 
Pro Asn His Gly Ser Pro Pro Gly Leu Tyr Arg Ala Asn Leu Gly Lys
                405                 410                 415     
Leu Gly Ala Tyr Pro Trp Ser Gln Ser Ser Pro Ala Leu Asn His Asn
            420                 425                 430         
Ser Thr Ser Pro Leu Thr Leu Ala Val Gly Ser Pro Leu Leu Pro Arg
        435                 440                 445             
Ser Arg Pro Leu Leu Gln Phe His Arg Gly Ala Pro Ala Leu Ser Arg
    450                 455                 460                 
Phe Pro Glu Asn Gly Leu Pro Gly Ser Gln Glu Pro Ser Pro Leu Arg
465                 470                 475                 480 
Gly Arg Trp Val Pro Gly Thr Thr Leu Glu Thr Val Glu Glu Lys Glu
                485                 490                 495     
Lys Lys Ala Ser Pro Ser Gln Ser Arg Gly Gln Leu Asp Leu Leu Val
            500                 505                 510         
Pro Phe Pro Arg Ala Arg Glu Val Gly Asp Pro Asp Ser Gly Val Thr
        515                 520                 525             
Pro Asn Ser Gly Pro Leu Arg Pro Gly Glu Gln Ala Pro Glu Asp Arg
    530                 535                 540                 
Arg Leu Ser Pro Ser Gln Ala Asp Ser Gln Leu Asp Leu Leu Ser Arg
545                 550                 555                 560 
Ala Leu Gly Thr Gly Gly Ala Pro Glu Leu Gly Ser Leu Arg Pro Gly
                565                 570                 575     
Asp Arg Ala Leu Glu Asp Arg Arg Leu Ser Leu Asn Gln Ser Arg Gly
            580                 585                 590         
Gln Ser Asp Leu Leu Met Gln Tyr Pro Lys Ala Gln Gly Ser Arg Val
        595                 600                 605             
Pro Leu Glu Thr Asn Ser Ser Ala Arg Pro Ala Arg Arg Ala Pro Asp
    610                 615                 620                 
Glu Arg Arg Gln Thr Leu Gly His Ser Gln Leu Asp Leu Ile Thr Lys
625                 630                 635                 640 
Phe Gly Pro Phe Arg Gly Glu Gly Pro Gly Pro Asn Gly Leu Pro Ile
                645                 650                 655     
Ser Ser Pro Ala Arg Thr Ala Gly Ala Gly Ser Gly Asp Glu Lys Arg
            660                 665                 670         
Leu Thr Leu Gly His Ser Lys Leu Asp Leu Ile Thr Lys Tyr His Gln
        675                 680                 685             
Leu His Gly Ala Arg Gln Gly Thr Glu Pro Gly Gly Pro Lys Gly Gly
    690                 695                 700                 
His Leu Asn Gly Gly Asn Ser Asp Leu Val Arg Asp Glu Lys Arg Leu
705                 710                 715                 720 
Thr Leu Gly His Ser Lys Leu Asp Leu Ile Thr Lys Tyr Asn Lys Ser
                725                 730                 735     
Lys Phe Lys Gln Leu Arg Ser Arg Phe Glu Ser
            740                 745         


<210> 6114
<211> 400
<212> PRT
<213> Homo sapiens

<400> 6114
Met Ala Ala Glu Ile Gln Pro Lys Pro Leu Thr Arg Lys Pro Ile Leu
 1               5                  10                  15      
Leu Gln Arg Met Glu Gly Ser Gln Glu Val Val Asn Met Ala Val Ile
            20                  25                  30          
Val Pro Lys Glu Glu Gly Val Ile Ser Val Ser Glu Asp Arg Thr Val
        35                  40                  45              
Arg Val Trp Leu Lys Arg Asp Ser Gly Gln Tyr Trp Pro Ser Val Tyr
    50                  55                  60                  
His Ala Met Pro Ser Pro Cys Ser Cys Met Ser Phe Asn Pro Glu Thr
65                  70                  75                  80  
Arg Arg Leu Ser Ile Gly Leu Asp Asn Gly Thr Ile Ser Glu Phe Ile
                85                  90                  95      
Leu Ser Glu Asp Tyr Asn Lys Met Thr Pro Val Lys Asn Tyr Gln Ala
            100                 105                 110         
His Gln Ser Arg Val Thr Met Ile Leu Phe Val Leu Glu Leu Glu Trp
        115                 120                 125             
Val Leu Ser Thr Gly Gln Asp Lys Gln Phe Ala Trp His Cys Ser Glu
    130                 135                 140                 
Ser Gly Gln Arg Leu Gly Gly Tyr Arg Thr Ser Ala Val Ala Ser Gly
145                 150                 155                 160 
Leu Gln Phe Asp Val Glu Thr Arg His Val Phe Ile Gly Asp His Ser
                165                 170                 175     
Gly Gln Val Thr Ile Leu Lys Leu Glu Gln Glu Asn Cys Thr Leu Val
            180                 185                 190         
Thr Thr Phe Arg Gly His Thr Gly Gly Val Thr Ala Leu Cys Trp Asp
        195                 200                 205             
Pro Val Gln Arg Val Leu Phe Ser Gly Ser Ser Asp His Ser Val Ile
    210                 215                 220                 
Met Trp Asp Ile Gly Gly Arg Lys Gly Thr Ala Ile Glu Leu Gln Gly
225                 230                 235                 240 
His Asn Asp Arg Val Gln Ala Leu Ser Tyr Ala Gln His Thr Arg Gln
                245                 250                 255     
Leu Ile Ser Cys Gly Gly Asp Gly Gly Ile Val Val Trp Asn Met Asp
            260                 265                 270         
Val Glu Arg Gln Glu Thr Pro Glu Trp Leu Asp Ser Asp Ser Cys Gln
        275                 280                 285             
Lys Cys Asp Gln Pro Phe Phe Trp Asn Phe Lys Gln Met Trp Asp Ser
    290                 295                 300                 
Lys Lys Ile Gly Leu Arg Gln His His Cys Arg Lys Cys Gly Lys Ala
305                 310                 315                 320 
Val Cys Gly Lys Cys Ser Ser Lys Arg Ser Ser Ile Pro Leu Met Gly
                325                 330                 335     
Phe Glu Phe Glu Val Arg Val Cys Asp Ser Cys His Glu Ala Ile Thr
            340                 345                 350         
Asp Glu Glu Arg Ala Pro Thr Ala Thr Phe His Asp Ser Lys His Asn
        355                 360                 365             
Ile Val His Val His Phe Asp Ala Thr Arg Gly Trp Leu Leu Thr Ser
    370                 375                 380                 
Gly Thr Asp Lys Val Ile Lys Leu Trp Asp Met Thr Pro Val Val Ser
385                 390                 395                 400 


<210> 6115
<211> 1010
<212> PRT
<213> Homo sapiens

<400> 6115
Met Arg Arg Pro Pro Pro Leu Gly Pro Thr Thr Ala Ser Gly Pro Glu
 1               5                  10                  15      
Gly Asn Val Arg Asn Leu Gln Lys Arg Gln Ala Pro Gly Pro Gly Ala
            20                  25                  30          
Ala Gly Gly Cys Gly Pro Glu Ala Gly Gly Cys Arg Glu Asn Lys Gln
        35                  40                  45              
Lys Arg Arg Met Val Ala Arg Ala Thr Pro Gly Arg Gly Glu Val Glu
    50                  55                  60                  
Ser Asp Lys Ser Val Ala Ala Ser Gly Ala Gly Lys Ala Ala Arg Arg
65                  70                  75                  80  
Gln Val Glu Gly Arg Arg Gly Pro Val Ser Pro Ser Asp Ser Ser Asp
                85                  90                  95      
Pro Arg Gly Leu Glu Ala Ala Lys Glu Ala Glu Leu Pro Leu Gln Thr
            100                 105                 110         
Glu Arg His Thr Lys Glu Lys Arg Lys Val Thr Glu Ala Ser Ser Asp
        115                 120                 125             
Asp Pro Gln Pro Gly Leu Asp Leu Val Arg Lys Glu Ser Leu Thr Ser
    130                 135                 140                 
Ser Glu Ser Phe Gln Thr Val Glu Cys Leu Gln Ser Leu Gly Lys Glu
145                 150                 155                 160 
Ser Ile Ile Glu Gly Ile Lys Arg Arg Ile Arg Asn Lys Lys Leu Lys
                165                 170                 175     
Ser Leu Glu Asn Pro Pro Leu Lys Ile Thr Glu Asn Glu Ala Thr Gln
            180                 185                 190         
Asn Ile Lys Val Glu Phe Gln Asp Glu Leu Tyr Lys Asn Thr Pro Lys
        195                 200                 205             
Tyr Ser Cys Asn Ile Leu Ser Pro Glu Val Glu Asn Asn Ser Val Leu
    210                 215                 220                 
Lys Leu Arg Asp Cys Asn Cys Phe Pro His Ser Lys Gly Cys Asn Asp
225                 230                 235                 240 
Glu Asn Asn Leu Pro Tyr Lys Pro Asp Gly Gly Cys Met His Val Ala
                245                 250                 255     
Glu Asn Phe Ser Lys Lys Glu Asn Leu Arg Ser Leu Ala Glu Lys Ser
            260                 265                 270         
Asp Thr Asn Ser Ile Pro Gln Leu Leu Gln Thr Glu Glu Asn Val Met
        275                 280                 285             
Gly Val Asn Lys Leu Leu Pro Glu Glu Ser Asp Leu Tyr Gln Ser Lys
    290                 295                 300                 
Thr Asn Gly Leu Leu Ser Cys Leu Gln His Glu Lys Asn Lys Tyr Ser
305                 310                 315                 320 
Ile Glu Glu Ser Ser Val Gly Arg Lys Pro Arg Lys Arg Met Lys Leu
                325                 330                 335     
Ser Glu Lys Ala Asp Glu Thr Val Thr Glu Met Asn Phe Ser Asn Glu
            340                 345                 350         
Tyr Asn Lys Ser Glu Leu Met Leu Gln Glu Asn Gln Met Ile Ala Asp
        355                 360                 365             
Gly Lys Glu Ala Glu Thr Lys Ser Pro Leu Asn Val Leu Arg Lys Val
    370                 375                 380                 
Ser His Asn Thr Val Ser Leu Met Asp His Leu Leu Ser Val Pro Glu
385                 390                 395                 400 
Thr Val Glu Lys Glu Thr Ser Ser Glu His His Val Asn Ala Val Phe
                405                 410                 415     
Gln Lys Thr Ile Glu Pro Leu Leu Lys Glu Glu Thr Glu Asn Ala Ser
            420                 425                 430         
Glu Pro Leu Gly Tyr Glu Ser Met Ala Ser Lys Glu Asp Phe Lys Ser
        435                 440                 445             
Met Lys Ser Phe Ile Gly Lys Ser Pro Asn Glu Tyr His Ile Glu Arg
    450                 455                 460                 
Arg Ser Ser Arg Glu Asp Leu Arg Ser Ala Ser Glu Glu Leu Lys Leu
465                 470                 475                 480 
Ser Cys Gln Arg Thr Ile Pro Met Thr Gly Lys Arg Thr Trp Pro Tyr
                485                 490                 495     
Tyr Ser Cys Ala Arg Ile Ser Ala Trp Cys Trp Lys Lys Ala Ser Leu
            500                 505                 510         
Pro Glu Ser Ser Tyr Phe Leu Arg Gly Ser Gln Glu Ser Cys Arg Gln
        515                 520                 525             
Val Asp Val Pro Lys His Gln Thr Asn Gln Thr His Leu Thr Asp Ser
    530                 535                 540                 
Lys Leu Leu Leu Gln Ser Ser Leu Thr Glu Thr Asn Thr Glu Ser Ser
545                 550                 555                 560 
Ser Lys Glu Lys Leu Asp Ser Asn Ser Asn Cys Leu Ser Ser Val Ser
                565                 570                 575     
Ala Val Glu Pro Thr Leu Met Val Ile Lys Glu Pro Ile Ile Lys Asp
            580                 585                 590         
Asp Lys Lys Ile Lys Ser Glu Glu Leu Ser Arg Arg Gly Ser Glu Val
        595                 600                 605             
Ile Ser Asn Thr Thr Glu Asp Thr Gln Leu Thr Ser Glu Thr Gln Ser
    610                 615                 620                 
Leu Thr Gly Asn Lys Lys Lys Ala Arg Gly Asn Leu Thr Lys Leu Asn
625                 630                 635                 640 
Leu Thr Ala Thr Ser Lys Asp Gly Gln Glu Ala Asn Asn Ser Ala Gly
                645                 650                 655     
Lys Thr Ile His Arg Lys Ala Cys Ile Ala Gln Gln Thr Phe Ile Val
            660                 665                 670         
Pro Asp Leu Val Lys Ile Leu Asn Thr Gly Arg Leu Thr Asn Phe Lys
        675                 680                 685             
Ile Pro Leu Leu Lys Asn Lys Ser Glu Lys Arg Lys Glu Val Asn Ala
    690                 695                 700                 
Lys Ser Ser Glu Arg Glu Ala Tyr Ser Pro Leu Glu Leu Leu Asp Asn
705                 710                 715                 720 
Leu Ser Gly Ala Asp Val Arg Gln Asn Arg Ser Lys Glu Asn Val Ser
                725                 730                 735     
Met Met Met Leu Gly Pro Gln Thr Leu Ser Ile Arg Asn Ser Val Thr
            740                 745                 750         
Pro Val Gln Ala Ser Ser Asp Ser Phe Tyr Asn Lys Lys Ser Tyr Ser
        755                 760                 765             
Ile Ser Pro Ser Phe Thr Lys Gln Gly Asn Asn Ser Lys Pro Ser Asn
    770                 775                 780                 
His Val Ser Glu Pro Gly Asn Ile Val Ser Asn Lys Glu Val Ala Ser
785                 790                 795                 800 
Leu Thr Val Glu Asn Asn Ala Phe Ser Cys Asp Pro Gly Tyr Val Glu
                805                 810                 815     
Lys Ser Pro Ser Phe Cys Cys Asn Glu Gln Glu Thr Phe Arg Pro Val
            820                 825                 830         
Ser Ser Glu Val Arg Gly Arg Lys Ile Thr Lys Asn Phe Ser Glu Val
        835                 840                 845             
Gly Phe Pro Asp Ile Leu Lys Ala Tyr Glu Asp Asp Val Leu Leu Ile
    850                 855                 860                 
Asp Val Ile Gln Asp Asp Pro Asp Leu Phe Gly Val Ser Asn Glu Gly
865                 870                 875                 880 
Glu Leu Ser Phe Thr Ser Glu Val Pro Lys Ile Ser Gln Glu Pro Asn
                885                 890                 895     
Val Ala Gly Glu His Gln Ser Thr Asp Ser Lys Tyr Met Glu Thr Pro
            900                 905                 910         
Val Lys Lys Glu Pro Ser Asp Asp Leu Arg Glu Leu Pro Val Leu Asp
        915                 920                 925             
Cys Gly Trp Ile Lys Pro Asp Ile Cys Ala Ser Asn Ser Ala Glu Ser
    930                 935                 940                 
Glu Ile Lys Arg Asp Pro Lys Asp Val Asn Thr Ser Leu Gly Glu Val
945                 950                 955                 960 
Ala Asn Glu Thr Ser Glu Asn Glu Thr Leu Gly Asp Phe Ser Glu Gln
                965                 970                 975     
Ile Lys Gly Ser Asp Leu Asp Glu Lys His Arg Phe Thr Asp Lys Val
            980                 985                 990         
Ile Thr Lys Glu Glu Lys Glu Asn Ile Tyr Glu Val Cys Lys Arg Ser
        995                 1000                1005            
Val Thr
    1010


<210> 6116
<211> 585
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 45
<223> Xaa = Any Amino Acid

<400> 6116
Met Ala Trp Arg Arg Pro Glu Pro Lys Thr Ser Ala Pro Pro Cys Thr
 1               5                  10                  15      
Thr Pro Pro Val Thr Ala Arg Gly Gln Leu Leu Gln Lys Leu Leu Ser
            20                  25                  30          
Ser Arg Ser Arg Glu Glu Leu Asp Glu Leu Thr Gly Xaa Val Ala Gly
        35                  40                  45              
Gly Gly Thr Pro Leu Leu Ile Ala Ala Cys Tyr Gly His Leu Asp Val
    50                  55                  60                  
Val Glu Tyr Leu Val Asp Pro Cys Gly Ala Ser Val Glu Ala Gly Gly
65                  70                  75                  80  
Ser Val His Phe Asp Gly Glu Thr Met Glu Gly Ala Pro Pro Leu Val
                85                  90                  95      
Gly Ala Asp His Leu Asp Val Val Arg Ser Leu Leu Arg Arg Gly Ala
            100                 105                 110         
Ser Val Asn Cys Thr Thr Arg Thr Asn Ser Thr Pro Leu Arg Ala Ala
        115                 120                 125             
Cys Phe Glu Gly Leu Leu Glu Val Val Arg Tyr Leu Val Gly Glu His
    130                 135                 140                 
Gln Ala Asn Leu Glu Val Ala Asn Arg His Gly His Met Cys Leu Met
145                 150                 155                 160 
Ile Ser Cys Tyr Lys Gly His Arg Glu Ile Ala Arg Tyr Leu Leu Glu
                165                 170                 175     
Gln Gly Ala Gln Val Asn Trp Arg Ser Ala Lys Gly Asn Thr Ala Leu
            180                 185                 190         
His Asn Cys Ala Glu Thr Ser Ser Leu Glu Ile Leu Gln Leu Leu Leu
        195                 200                 205             
Gly Cys Lys Ala Ser Met Glu Arg Asp Ser Tyr Gly Met Thr Pro Leu
    210                 215                 220                 
Leu Pro Ala Ser Val Thr Gly His Thr Asn Ile Val Glu Tyr Leu Ile
225                 230                 235                 240 
Gln Glu Gln Pro Gly Gln Glu Gln Leu Ile Gly Val Glu Ala Gln Leu
                245                 250                 255     
Arg Leu Pro Gln Glu Gly Ser Ser Thr Ser Gln Gly Cys Ala Gln Pro
            260                 265                 270         
Gln Gly Ala Pro Cys Cys Ile Phe Ser Pro Glu Val Leu Asn Gly Glu
        275                 280                 285             
Ser Tyr Gln Ser Cys Cys Pro Thr Ser Arg Glu Ala Ala Met Glu Ala
    290                 295                 300                 
Leu Glu Leu Leu Gly Ser Thr Tyr Val Asp Lys Lys Arg Asp Leu Leu
305                 310                 315                 320 
Gly Ala Leu Lys His Trp Arg Arg Ala Met Glu Leu Arg His Gln Gly
                325                 330                 335     
Gly Glu Tyr Leu Pro Lys Leu Glu Pro Pro Gln Leu Val Leu Ala Tyr
            340                 345                 350         
Asp Tyr Ser Arg Glu Val Asn Thr Thr Glu Glu Leu Glu Ala Leu Ile
        355                 360                 365             
Thr Asp Ala Asp Glu Met Arg Met Gln Ala Leu Leu Ile Arg Glu Arg
    370                 375                 380                 
Ile Leu Ser Pro Ser His Pro Asp Thr Ser Tyr Cys Ile Arg Tyr Arg
385                 390                 395                 400 
Gly Ala Val Tyr Ala Asp Ser Gly Asn Ile Glu Cys Tyr Ile Arg Leu
                405                 410                 415     
Trp Lys Tyr Ala Leu Asp Met Gln Gln Ser Asn Leu Glu Pro Leu Ser
            420                 425                 430         
Pro Met Ser Ala Ser Ser Phe Leu Ser Phe Ala Glu Leu Phe Ser Tyr
        435                 440                 445             
Val Leu Gln Asp Pro Ala Ala Lys Gly Ser Leu Gly Thr Gln Ile Gly
    450                 455                 460                 
Phe Ala Asp Leu Met Gly Val Leu Thr Lys Gly Val Arg Glu Val Glu
465                 470                 475                 480 
Trp Ala Leu Gln Leu Leu Arg Glu Pro Arg Asp Ser Ala Gln Phe Asn
                485                 490                 495     
Lys Ala Leu Ala Ile Ile Leu His Leu Leu Tyr Leu Leu Glu Lys Val
            500                 505                 510         
Glu Cys Thr Pro Ser Gln Glu His Leu Lys His Gln Thr Ile Tyr Arg
        515                 520                 525             
Leu Leu Lys Cys Ala Pro Arg Gly Lys Asn Gly Phe Thr Val Pro Val
    530                 535                 540                 
Pro Pro Lys Ala Gln Ser Arg Glu Met Arg Leu Phe Thr Ser Arg Val
545                 550                 555                 560 
Ser Val Leu Val Phe Lys Ser Leu Lys Arg Tyr Ser Lys Lys Lys Ser
                565                 570                 575     
Leu Asn Thr Gly Leu Trp Asn Asn Ser
            580                 585 


<210> 6117
<211> 132
<212> PRT
<213> Homo sapiens

<400> 6117
Met Asp Gln Gly Gly Leu Gln Gln Trp Val Gly Val Asp Gln Val Asn
 1               5                  10                  15      
Arg Ala Gly Gly Gly Gln Gly Met Leu Asp Arg Gly Val Cys Pro Ser
            20                  25                  30          
Lys Gly Arg Arg Gly Ala Ile Lys His Gln Val Asn Phe Ser Ser Gly
        35                  40                  45              
Gly Val Ala Pro Leu Gly Gly Ser Trp His Arg Leu Glu Ser Asp Arg
    50                  55                  60                  
Ala Arg Trp Trp Arg Gly Leu Val His Val Ser Gly Arg Leu Leu Thr
65                  70                  75                  80  
Gly Ile Ser Ile Ser Ile Cys Pro Lys Arg Thr Tyr Thr Leu His Ala
                85                  90                  95      
Pro Leu Ser Cys Phe Ser Cys Leu Leu Met Arg Gln Ala Thr Leu Gln
            100                 105                 110         
Ile Leu Ser Cys Ser Lys Leu Gly Ala Leu Gly Trp Thr Phe Ile Ala
        115                 120                 125             
Gly Pro Asp Cys
    130         


<210> 6118
<211> 208
<212> PRT
<213> Homo sapiens

<400> 6118
Met Lys Lys Asn Glu Val Tyr Glu Thr Phe Ser Tyr Pro Glu Ser Tyr
 1               5                  10                  15      
Ser Pro Thr Leu Pro Val Ser Arg Arg Glu Asn Asn Ser Pro Ser Asn
            20                  25                  30          
Leu Pro Arg Pro Ser Phe Cys Met Glu Glu Tyr Gln Arg Ala Glu Leu
        35                  40                  45              
Glu Glu Asp Pro Ile Leu Ser Arg Thr Pro Ser Pro Val His Pro Ser
    50                  55                  60                  
Asp Phe Ser Glu His Asn Cys Gln Pro Tyr Tyr Ala Ser Asp Gly Ala
65                  70                  75                  80  
Thr Tyr Gly Ser Ser Ser Gly Leu Cys Leu Gly Asn Pro Arg Ala Asp
                85                  90                  95      
Ser Ile His Asn Thr Tyr Ser Thr Asp His Ala Ser Ala Ala Pro Pro
            100                 105                 110         
Ser Val Thr Arg Ser Pro Val Glu Asn Asp Gly Tyr Ile Glu Glu Gly
        115                 120                 125             
Ser Ile Thr Lys His Pro Ser Thr Trp Ser Val Glu Ala Val Val Leu
    130                 135                 140                 
Phe Leu Lys Gln Thr Asp Pro Leu Ala Leu Cys Pro Leu Val Asp Leu
145                 150                 155                 160 
Phe Arg Ser His Glu Ile Asp Gly Lys Ala Leu Leu Leu Leu Thr Ser
                165                 170                 175     
Asp Val Leu Leu Lys His Leu Gly Val Lys Leu Gly Thr Ala Val Lys
            180                 185                 190         
Leu Cys Tyr Tyr Ile Asp Arg Leu Lys Gln Gly Lys Cys Phe Glu Asn
        195                 200                 205             


<210> 6119
<211> 1299
<212> PRT
<213> Homo sapiens

<400> 6119
Met Glu Pro Pro Ser Cys Ile Gln Asp Glu Pro Phe Pro His Pro Leu
 1               5                  10                  15      
Glu Pro Glu Pro Gly Val Ser Ala Gln Pro Gly Pro Gly Lys Pro Ser
            20                  25                  30          
Asp Lys Arg Phe Arg Leu Trp Tyr Val Gly Gly Ser Cys Leu Asp His
        35                  40                  45              
Arg Thr Thr Leu Pro Met Leu Pro Trp Leu Met Ala Glu Ile Arg Arg
    50                  55                  60                  
Arg Ser Gln Lys Pro Glu Ala Gly Gly Cys Gly Ala Pro Ala Ala Arg
65                  70                  75                  80  
Glu Val Ile Leu Val Leu Ser Ala Pro Phe Leu Arg Cys Val Pro Ala
                85                  90                  95      
Pro Gly Ala Gly Ala Ser Gly Gly Thr Ser Pro Ser Ala Thr Gln Pro
            100                 105                 110         
Asn Pro Ala Val Phe Ile Phe Glu His Lys Ala Gln His Ile Ser Arg
        115                 120                 125             
Phe Ile His Asn Ser His Asp Leu Thr Tyr Phe Ala Tyr Leu Ile Lys
    130                 135                 140                 
Ala Gln Pro Asp Asp Pro Glu Ser Gln Met Ala Cys His Val Phe Arg
145                 150                 155                 160 
Ala Thr Asp Pro Ser Gln Val Pro Asp Val Ile Ser Ser Ile Arg Gln
                165                 170                 175     
Leu Ser Lys Ala Ala Met Lys Glu Asp Ala Lys Pro Ser Lys Asp Asn
            180                 185                 190         
Glu Asp Ala Phe Tyr Asn Ser Gln Lys Phe Glu Val Leu Tyr Cys Gly
        195                 200                 205             
Lys Val Thr Val Thr His Lys Lys Ala Pro Ser Ser Leu Ile Asp Asp
    210                 215                 220                 
Cys Met Glu Lys Phe Ser Leu His Glu Gln Gln Arg Leu Lys Ile Gln
225                 230                 235                 240 
Gly Glu Gln Arg Gly Pro Asp Pro Gly Glu Asp Leu Ala Asp Leu Glu
                245                 250                 255     
Val Val Val Pro Gly Ser Pro Gly Asp Cys Leu Pro Glu Glu Ala Asp
            260                 265                 270         
Gly Thr Asp Thr His Leu Gly Leu Pro Ala Gly Ala Ser Gln Pro Ala
        275                 280                 285             
Leu Thr Ser Ser Arg Val Cys Phe Pro Glu Arg Ile Leu Glu Asp Ser
    290                 295                 300                 
Gly Phe Asp Glu Gln Gln Glu Phe Arg Ser Arg Cys Ser Ser Val Thr
305                 310                 315                 320 
Gly Val Gln Arg Arg Val His Glu Gly Ser Gln Lys Ser Gln Pro Arg
                325                 330                 335     
Arg Arg His Ala Ser Ala Pro Ser His Val Gln Pro Ser Asp Ser Glu
            340                 345                 350         
Lys Asn Arg Thr Met Leu Phe Gln Val Gly Arg Phe Glu Ile Asn Leu
        355                 360                 365             
Ile Ser Pro Asp Thr Lys Ser Val Val Leu Glu Lys Asn Phe Lys Asp
    370                 375                 380                 
Ile Ser Ser Cys Ser Gln Gly Ile Lys His Val Asp His Phe Gly Phe
385                 390                 395                 400 
Ile Cys Arg Glu Ser Pro Glu Pro Gly Leu Ser Gln Tyr Ile Cys Tyr
                405                 410                 415     
Val Phe Gln Cys Ala Ser Glu Ser Leu Val Asp Glu Val Met Leu Thr
            420                 425                 430         
Leu Lys Gln Ala Phe Ser Thr Ala Ala Ala Leu Gln Ser Ala Lys Thr
        435                 440                 445             
Gln Ile Lys Leu Cys Glu Ala Cys Pro Met His Ser Leu His Lys Leu
    450                 455                 460                 
Cys Glu Arg Ile Glu Gly Leu Tyr Pro Pro Arg Ala Lys Leu Val Ile
465                 470                 475                 480 
Gln Arg His Leu Ser Ser Leu Thr Asp Asn Glu Gln Ala Asp Ile Phe
                485                 490                 495     
Glu Arg Val Gln Lys Met Lys Pro Val Ser Asp Gln Glu Glu Asn Glu
            500                 505                 510         
Leu Val Ile Leu His Leu Arg Gln Leu Cys Glu Ala Lys Gln Lys Thr
        515                 520                 525             
His Val His Ile Gly Glu Gly Pro Ser Thr Ile Ser Asn Ser Thr Ile
    530                 535                 540                 
Pro Glu Asn Ala Thr Ser Ser Gly Arg Phe Lys Leu Asp Ile Leu Lys
545                 550                 555                 560 
Asn Lys Ala Lys Arg Ser Leu Thr Ser Ser Leu Glu Asn Ile Phe Ser
                565                 570                 575     
Arg Gly Ala Asn Arg Met Arg Gly Arg Leu Gly Ser Val Asp Ser Phe
            580                 585                 590         
Glu Arg Ser Asn Ser Leu Ala Ser Glu Lys Asp Tyr Ser Pro Gly Asp
        595                 600                 605             
Ser Pro Pro Gly Thr Pro Pro Ala Ser Pro Pro Ser Ser Ala Trp Gln
    610                 615                 620                 
Thr Phe Pro Glu Glu Asp Ser Asp Ser Pro Gln Phe Arg Arg Arg Ala
625                 630                 635                 640 
His Thr Phe Ser His Pro Pro Ser Ser Thr Lys Arg Lys Leu Asn Leu
                645                 650                 655     
Gln Asp Gly Arg Ala Gln Gly Val Arg Ser Pro Leu Leu Arg Gln Ser
            660                 665                 670         
Ser Ser Glu Gln Cys Ser Asn Leu Ser Ser Val Arg Arg Met Tyr Lys
        675                 680                 685             
Glu Ser Asn Ser Ser Ser Ser Leu Pro Ser Leu His Thr Ser Phe Ser
    690                 695                 700                 
Ala Pro Ser Phe Thr Ala Pro Ser Phe Leu Lys Ser Phe Tyr Gln Asn
705                 710                 715                 720 
Ser Gly Arg Leu Ser Pro Gln Tyr Glu Asn Glu Ile Arg Gln Asp Thr
                725                 730                 735     
Ala Ser Glu Ser Ser Asp Gly Glu Gly Arg Lys Arg Thr Ser Ser Thr
            740                 745                 750         
Cys Ser Asn Glu Ser Leu Ser Val Gly Gly Thr Ser Val Thr Pro Arg
        755                 760                 765             
Arg Ile Ser Trp Arg Gln Arg Ile Phe Leu Arg Val Ala Ser Pro Met
    770                 775                 780                 
Asn Lys Ser Pro Ser Ala Met Gln Gln Gln Asp Gly Leu Asp Arg Asn
785                 790                 795                 800 
Glu Leu Leu Pro Leu Ser Pro Leu Ser Pro Thr Met Glu Glu Glu Pro
                805                 810                 815     
Leu Val Ile Phe Leu Ser Gly Glu Asp Asp Pro Glu Lys Ile Glu Glu
            820                 825                 830         
Arg Lys Lys Ser Lys Glu Leu Arg Ser Leu Trp Arg Lys Ala Ile His
        835                 840                 845             
Gln Gln Ile Leu Leu Leu Arg Met Glu Lys Glu Asn Gln Lys Leu Glu
    850                 855                 860                 
Gly Ala Ser Arg Asp Glu Leu Gln Ser Arg Lys Val Lys Leu Asp Tyr
865                 870                 875                 880 
Glu Glu Val Gly Ala Cys Gln Lys Glu Val Leu Ile Thr Trp Asp Lys
                885                 890                 895     
Lys Leu Leu Asn Cys Arg Ala Lys Ile Arg Cys Asp Met Glu Asp Ile
            900                 905                 910         
His Thr Leu Leu Lys Glu Gly Val Pro Lys Ser Arg Arg Gly Glu Ile
        915                 920                 925             
Trp Gln Phe Leu Ala Leu Gln Tyr Arg Leu Arg His Arg Leu Pro Asn
    930                 935                 940                 
Lys Gln Gln Pro Pro Asp Ile Ser Tyr Lys Glu Leu Leu Lys Gln Leu
945                 950                 955                 960 
Thr Ala Gln Gln His Ala Ile Leu Val Asp Leu Gly Arg Thr Phe Pro
                965                 970                 975     
Thr His Pro Tyr Phe Ser Val Gln Leu Gly Pro Gly Gln Leu Ser Leu
            980                 985                 990         
Phe Asn Leu Leu Lys Ala Tyr Ser Leu Leu Asp Lys Glu Val Gly Tyr
        995                 1000                1005            
Cys Gln Gly Ile Ser Phe Val Ala Gly Val Leu Leu Leu His Met Ser
    1010                1015                1020                
Glu Glu Gln Ala Phe Glu Met Leu Lys Phe Leu Met Tyr Asp Leu Gly
1025                1030                1035                1040
Phe Arg Lys Gln Tyr Arg Pro Asp Met Met Ser Leu Gln Ile Gln Met
                1045                1050                1055    
Tyr Gln Leu Ser Arg Leu Leu His Asp Tyr His Arg Asp Leu Tyr Asn
            1060                1065                1070        
His Leu Glu Glu Asn Glu Ile Ser Pro Ser Leu Tyr Ala Ala Pro Trp
        1075                1080                1085            
Phe Leu Thr Leu Phe Ala Ser Gln Phe Ser Leu Gly Phe Val Ala Arg
    1090                1095                1100                
Val Phe Asp Ile Ile Phe Leu Gln Gly Thr Glu Val Ile Phe Lys Val
1105                1110                1115                1120
Ala Leu Ser Leu Leu Ser Ser Gln Glu Thr Leu Ile Met Glu Cys Glu
                1125                1130                1135    
Ser Phe Glu Asn Ile Val Glu Phe Leu Lys Asn Thr Leu Pro Asp Met
            1140                1145                1150        
Asn Thr Ser Glu Met Glu Lys Ile Ile Thr Gln Val Phe Glu Met Asp
        1155                1160                1165            
Ile Ser Lys Gln Leu His Ala Tyr Glu Val Glu Tyr His Val Leu Gln
    1170                1175                1180                
Asp Glu Leu Gln Glu Ser Ser Tyr Ser Cys Glu Asp Ser Glu Thr Leu
1185                1190                1195                1200
Glu Lys Leu Glu Arg Ala Asn Ser Gln Leu Lys Arg Gln Asn Met Asp
                1205                1210                1215    
Leu Leu Glu Lys Leu Gln Val Ala His Thr Lys Ile Gln Ala Leu Glu
            1220                1225                1230        
Ser Asn Leu Glu Asn Leu Leu Thr Arg Glu Thr Lys Met Lys Ser Leu
        1235                1240                1245            
Ile Arg Thr Leu Glu Gln Glu Lys Met Ala Tyr Gln Lys Thr Val Glu
    1250                1255                1260                
Gln Leu Arg Lys Leu Leu Pro Ala Asp Ala Leu Ala Asn Cys Asp Leu
1265                1270                1275                1280
Leu Leu Arg Asp Leu Asn Cys Asn Pro Asn Asn Lys Ala Lys Ile Gly
                1285                1290                1295    
Asn Lys Pro
            


<210> 6120
<211> 249
<212> PRT
<213> Homo sapiens

<400> 6120
Met Asp Ile Asp Arg Leu Glu Lys Lys Ile Glu Asp Leu Ser Lys Thr
 1               5                  10                  15      
Glu Thr Glu His Gln Met Gln Leu His Thr Tyr Glu Asn Thr Leu Leu
            20                  25                  30          
Asn Lys Asp Thr Ser Leu Gln Lys Lys Gly Leu Tyr Ile Glu Glu Leu
        35                  40                  45              
Lys Ser Thr Ile Ile Glu Tyr Gly Ser Ile Ile Glu Asn Leu Arg Gly
    50                  55                  60                  
Glu Lys Ser Lys Leu Ala His Glu Leu Gln His Leu Gln Gln Ala Leu
65                  70                  75                  80  
Ile Thr Asn Gly Ile Gln Leu Asn Val Asn Gly Glu Cys Asn Ser Ile
                85                  90                  95      
Ile Ser Glu Gly Glu Lys Ser Leu His Tyr Glu Leu Thr Leu Ala Gln
            100                 105                 110         
Ser Ala Glu Asn Thr Glu Thr Glu Arg Gln His Asn Val Ile Asn Leu
        115                 120                 125             
Ser Ser Leu Asp Ala Met Met Asp Gln Glu Met Leu Leu Leu Leu Arg
    130                 135                 140                 
Glu Pro Ala Gln Lys Ala Val Glu Phe Thr Ala Thr Leu Gln Lys Leu
145                 150                 155                 160 
His Glu Glu Ile Ser Lys Ile Ala Thr Leu Ile Glu Asn Ser Arg Arg
                165                 170                 175     
Trp Val Thr Asn Pro Glu Ile Thr Val Lys Glu Lys Trp Glu Glu Gln
            180                 185                 190         
Leu Thr Glu Phe Asn Asn Ile Met Glu Glu Lys Leu Asp Leu Cys Ile
        195                 200                 205             
Leu Met Leu Asn Ile Leu Gly Asn His Lys Glu Ser Leu Asp Lys Glu
    210                 215                 220                 
Phe Ala Lys Leu Ile Glu Ile Leu Lys Arg Phe Arg Gln Glu Tyr Phe
225                 230                 235                 240 
Tyr Phe Arg Lys Glu Phe Leu Ala Arg
                245                 


<210> 6121
<211> 502
<212> PRT
<213> Homo sapiens

<400> 6121
Met Trp Thr Ala Asp Glu Ile Ala Gln Leu Cys Tyr Glu His Tyr Gly
 1               5                  10                  15      
Ile Arg Leu Pro Lys Lys Gly Lys Pro Glu Pro Asn His Glu Trp Thr
            20                  25                  30          
Leu Leu Ala Ala Val Val Lys Ile Gln Ser Pro Ala Asp Lys Ala Cys
        35                  40                  45              
Asp Thr Pro Asp Lys Pro Val Gln Val Thr Lys Glu Val Val Ser Met
    50                  55                  60                  
Gly Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly
65                  70                  75                  80  
Asp Ile Leu Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser Phe
                85                  90                  95      
Gln Arg Tyr Leu Leu His Gln Leu Gln Leu Ala Ala Thr Leu Lys Glu
            100                 105                 110         
Asp Ser Ile Phe Val Pro Gly Thr Gln Lys Gly Val Trp Lys Leu Arg
        115                 120                 125             
Arg Asp Leu Ile Phe Val Phe Phe Ser Ser His Thr Pro Cys Gly Asp
    130                 135                 140                 
Ala Ser Ile Ile Pro Met Leu Glu Phe Glu Asp Gln Pro Cys Cys Pro
145                 150                 155                 160 
Val Phe Arg Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn
                165                 170                 175     
Leu Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro
            180                 185                 190         
Val Thr Lys Lys Met Arg Leu Glu Pro Gly Thr Ala Ala Arg Glu Val
        195                 200                 205             
Thr Asn Gly Ala Ala His His Gln Ser Phe Gly Lys Gln Lys Ser Gly
    210                 215                 220                 
Pro Ile Ser Pro Gly Ile His Ser Cys Asp Leu Thr Val Glu Gly Leu
225                 230                 235                 240 
Ala Thr Val Thr Arg Ile Ala Pro Gly Ser Ala Lys Val Ile Asp Val
                245                 250                 255     
Tyr Arg Thr Gly Ala Lys Cys Val Pro Gly Glu Ala Gly Asp Ser Gly
            260                 265                 270         
Lys Pro Gly Ala Ala Phe His Gln Val Gly Leu Leu Arg Val Lys Pro
        275                 280                 285             
Gly Arg Gly Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala
    290                 295                 300                 
Arg Trp Asn Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu
305                 310                 315                 320 
Glu Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro Tyr
                325                 330                 335     
Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys Gln Asn Val
            340                 345                 350         
Ser Ala Leu Pro Lys Gly Phe Gly Val Gln Glu Leu Lys Ile Leu Gln
        355                 360                 365             
Ser Asp Leu Leu Phe Glu Gln Ser Arg Ser Ala Val Gln Ala Lys Arg
    370                 375                 380                 
Ala Asp Ser Pro Gly Arg Leu Val Pro Cys Gly Ala Ala Ile Ser Trp
385                 390                 395                 400 
Ser Ala Val Pro Glu Gln Pro Leu Asp Val Thr Ala Asn Gly Phe Pro
                405                 410                 415     
Gln Gly Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln Ala Arg Ser Gln
            420                 425                 430         
Ile Ser Lys Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Arg
        435                 440                 445             
Ile Ala Arg Asp Lys Trp Pro His Ser Leu Arg Val Gln Lys Leu Asp
    450                 455                 460                 
Thr Tyr Gln Glu Tyr Lys Glu Ala Ala Ser Ser Tyr Gln Glu Ala Trp
465                 470                 475                 480 
Ser Thr Leu Arg Lys Gln Val Phe Gly Ser Trp Ile Arg Asn Pro Pro
                485                 490                 495     
Asp Tyr His Gln Phe Lys
            500         


<210> 6122
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 6122
Ser Thr Glu Arg Leu Asp Asn Lys Pro Glu Thr Thr Arg Tyr Asp Ser
 1               5                  10                  15      
Phe Gly Arg Leu Thr Asn Val Thr Phe Pro Thr Gly Gln Val Ser Ser
            20                  25                  30          
Phe Arg Ser Asp Thr Asp Ser Ser Val His Val Gln Val Glu Thr Ser
        35                  40                  45              
Ser Lys Asp Asp Val Thr Ile Thr Thr Asn Leu Ser Ala Ser Gly Ala
    50                  55                  60                  
Phe Tyr Thr Leu Leu Gln Asp Gln Val Arg Asn Ser Tyr Tyr Ile Gly
65                  70                  75                  80  
Ala Asp Gly Ser Leu Arg Leu Leu Leu Ala Asn Gly Met Glu Val Ala
                85                  90                  95      
Leu Gln Thr Glu Pro His Leu Leu Ala Gly Thr Val Asn Pro Thr Val
            100                 105                 110         
Gly Lys Arg Asn Val Thr Leu Pro Ile Asp Asn Gly Leu Asn Leu Val
        115                 120                 125             
Glu Trp Arg Gln Arg Lys Glu Gln Ala Arg Gly Gln Val Thr Val Phe
    130                 135                 140                 
Gly Arg Arg Leu Arg Val His Asn Arg Asn Leu Leu Ser Leu Asp Phe
145                 150                 155                 160 
Asp Arg Val Thr Arg Thr Glu Lys Ile Tyr Asp Asp His Arg Lys Phe
                165                 170                 175     
Thr Leu Arg Ile Leu Tyr Asp Gln Ala Gly Arg Pro Ser Leu Trp Ser
            180                 185                 190         
Pro Ser Ser Arg Leu Asn Gly Val Asn Val Thr Tyr Ser Pro Gly Gly
        195                 200                 205             
Tyr Ile Ala Gly Ile Gln Arg Gly Ile Met Ser Glu Arg Met Glu Tyr
    210                 215                 220                 
Asp Gln Ala Gly Arg Ile Thr Ser Arg Ile Phe Ala Asp Gly Lys Thr
225                 230                 235                 240 
Trp Ser Tyr Thr Tyr Leu Glu Lys Ser Met Val Leu Leu Leu His Ser
                245                 250                 255     
Gln Arg Gln Tyr Ile Phe Glu Phe Asp Lys Asn Asp Arg Leu Ser Ser
            260                 265                 270         
Val Thr Met Pro Asn Val Ala Arg Gln Thr Leu Glu Thr Ile Arg Ser
        275                 280                 285             
Val Gly Tyr Tyr Arg Asn Ile Tyr Gln Pro Pro Glu Gly Asn Ala Ser
    290                 295                 300                 
Val Ile Gln Asp Phe Thr Glu Asp Gly His Leu Leu His Thr Phe Tyr
305                 310                 315                 320 
Leu Gly Thr Gly Arg Arg Val Ile Tyr Lys Tyr Gly Lys Leu Ser Lys
                325                 330                 335     
Leu Ala Glu Thr Leu Tyr Asp Thr Thr Lys Val Ser Phe Thr Tyr Asp
            340                 345                 350         
Glu Thr Ala Gly Met Leu Lys Thr Ile Asn Leu Gln Asn Glu Gly Phe
        355                 360                 365             
Thr Cys Thr Ile Arg Tyr Arg Gln Ile Gly Pro Leu Ile Asp Arg Gln
    370                 375                 380                 
Ile Phe Arg Phe Thr Glu Glu Gly Met Val Asn Ala Arg Phe Asp Tyr
385                 390                 395                 400 
Asn Tyr Asp Asn Ser Phe Arg Val Thr Ser Met Gln Ala Val Ile Asn
                405                 410                 415     
Glu Thr Pro Leu Pro Ile Asp Leu Tyr Arg Tyr Asp Asp Val Ser Gly
            420                 425                 430         
Lys Thr Glu Gln Phe Gly Lys Phe Gly Val Ile Tyr Tyr Asp Ile Asn
        435                 440                 445             
Gln Ile Ile Thr Thr Ala Val Met Thr His Thr Lys His Phe Asp Ala
    450                 455                 460                 
Tyr Gly Arg Met Lys Glu Val Gln Tyr Glu Ile Phe Arg Ser Leu Met
465                 470                 475                 480 
Tyr Trp Met Thr Val Gln Tyr Asp Asn Met Gly Arg Val Val Lys Lys
                485                 490                 495     
Glu Leu Lys Val Gly Pro Tyr Ala Asn Thr Thr Arg Tyr Ser Tyr Glu
            500                 505                 510         
Tyr Asp Ala Asp Gly Gln Leu Gln Thr Val Ser Ile Asn Asp Lys Pro
        515                 520                 525             
Leu Trp Arg Tyr Ser Tyr Asp Leu Asn Gly Asn Leu His Leu Leu Ser
    530                 535                 540                 
Pro Gly Asn Ser Ala Arg Leu Thr Pro Leu Arg Tyr Asp Ile Arg Asp
545                 550                 555                 560 
Arg Ile Thr Arg Leu Gly Asp Val Gln Tyr Lys Met Asp Glu Asp Gly
                565                 570                 575     
Phe Leu Arg Gln Arg Gly Gly Asp Ile Phe Glu Tyr Asn Ser Ala Gly
            580                 585                 590         
Leu Leu Ile Lys Ala Tyr Asn Arg Ala Gly Ser Trp Ser Val Arg Tyr
        595                 600                 605             
Arg Tyr Asp Gly Leu Gly Arg Arg Val Ser Ser Lys Ser Ser His Ser
    610                 615                 620                 
His His Leu Gln Phe Phe Tyr Ala Asp Leu Thr Asn Pro Thr Lys Val
625                 630                 635                 640 
Thr His Leu Tyr Asn His Ser Ser Ser Glu Ile Thr Ser Leu Tyr Tyr
                645                 650                 655     
Asp Leu Gln Gly His Leu Phe Ala Met Glu Leu Ser Ser Gly Asp Glu
            660                 665                 670         
Phe Tyr Ile Ala Cys Asp Asn Ile Gly Thr Pro Leu Ala Val Phe Ser
        675                 680                 685             
Gly Thr Gly Leu Met Ile Lys Gln Ile Leu Tyr Thr Ala Tyr Gly Glu
    690                 695                 700                 
Ile Tyr Met Asp Thr Asn Pro Asn Phe Gln Ile Ile Ile Gly Tyr His
705                 710                 715                 720 
Gly Gly Leu Tyr Asp Pro Leu Thr Lys Leu Val His Met Gly Arg Arg
                725                 730                 735     
Asp Tyr Asp Val Leu Ala Gly Arg Trp Thr Ser Pro Asp His Glu Leu
            740                 745                 750         
Trp Lys His Leu Ser Ser Ser Asn Val Met Pro Phe Asn Leu Tyr Met
        755                 760                 765             
Phe Lys Asn Asn Asn Pro Ile Ser Asn Ser Gln Asp Ile Lys Cys Phe
    770                 775                 780                 
Met Thr Asp Val Asn Ser Trp Leu Leu Thr Phe Gly Phe Gln Leu His
785                 790                 795                 800 
Asn Val Ile Pro Gly Tyr Pro Lys Pro Asp Met Asp Ala Met Glu Pro
                805                 810                 815     
Ser Tyr Glu Leu Ile His Thr Gln Met Lys Thr Gln Glu Trp Asp Asn
            820                 825                 830         
Ser Lys Ser Ile Leu Gly Val Gln Cys Glu Val Gln Lys Gln Leu Lys
        835                 840                 845             
Ala Phe Val Thr Leu Glu Arg Phe Asp Gln Leu Tyr Gly Ser Thr Ile
    850                 855                 860                 
Thr Ser Cys Gln Gln Ala Pro Lys Thr Lys Lys Phe Ala Ser Ser Gly
865                 870                 875                 880 
Ser Val Phe Gly Lys Gly Val Lys Phe Ala Leu Lys Asp Gly Arg Val
                885                 890                 895     
Thr Thr Asp Ile Ile Ser Val Ala Asn Glu Asp Gly Arg Arg Val Ala
            900                 905                 910         
Ala Ile Leu Asn His Ala His Tyr Leu Glu Asn Leu His Phe Thr Ile
        915                 920                 925             
Asp Gly Val Asp Thr His Tyr Phe Val Lys Pro Gly Pro Ser Glu Gly
    930                 935                 940                 
Asp Leu Ala Ile Leu Gly Leu Ser Gly Gly Arg Arg Thr Leu Glu Asn
945                 950                 955                 960 
Gly Val Asn Val Thr Val Ser Gln Ile Asn Thr Val Leu Asn Gly Arg
                965                 970                 975     
Thr Arg Arg Tyr Thr Asp Ile Gln Leu Gln Tyr Gly Ala Leu Cys Leu
            980                 985                 990         
Asn Thr Arg Tyr Gly Thr Thr Leu Asp Glu Glu Lys Ala Arg Val Leu
        995                 1000                1005            
Glu Leu Ala Arg Gln Arg Ala Val Arg Gln Ala Trp Ala Arg Glu Gln
    1010                1015                1020                
Gln Arg Leu Arg Glu Gly Glu Glu Gly Leu Arg Ala Trp Thr Glu Gly
1025                1030                1035                1040
Glu Lys Gln Gln Val Leu Ser Thr Gly Arg Val Gln Gly Tyr Asp Gly
                1045                1050                1055    
Phe Phe Val Ile Ser Val Glu Gln Tyr Pro Glu Leu Ser Asp Ser Ala
            1060                1065                1070        
Asn Asn Ile His Phe Met Arg Gln Ser Glu Met Gly Arg Arg
        1075                1080                1085    


<210> 6123
<211> 780
<212> PRT
<213> Homo sapiens

<400> 6123
Met Glu Gln Val Glu Ile Leu Arg Lys Phe Ile Gln Arg Val Gln Ala
 1               5                  10                  15      
Met Lys Ser Pro Asp His Asn Gly Glu Asp Asn Phe Ala Arg Asp Phe
            20                  25                  30          
Met Arg Leu Arg Arg Leu Ser Thr Lys Tyr Arg Thr Glu Lys Ile Tyr
        35                  40                  45              
Pro Thr Ala Thr Gly Glu Lys Glu Glu Asn Val Lys Lys Asn Arg Tyr
    50                  55                  60                  
Lys Asp Ile Leu Pro Phe Asp His Ser Arg Val Lys Leu Thr Leu Lys
65                  70                  75                  80  
Thr Pro Ser Gln Asp Ser Asp Tyr Ile Asn Ala Asn Phe Ile Lys Gly
                85                  90                  95      
Val Tyr Gly Pro Lys Ala Tyr Val Ala Thr Gln Gly Pro Leu Ala Asn
            100                 105                 110         
Thr Val Ile Asp Phe Trp Arg Met Val Trp Glu Tyr Asn Val Val Ile
        115                 120                 125             
Ile Val Met Ala Cys Arg Glu Phe Glu Met Gly Arg Lys Lys Cys Glu
    130                 135                 140                 
Arg Tyr Trp Pro Leu Tyr Gly Glu Asp Pro Ile Thr Phe Ala Pro Phe
145                 150                 155                 160 
Lys Ile Ser Cys Glu Asp Glu Gln Ala Arg Thr Asp Tyr Phe Ile Arg
                165                 170                 175     
Thr Leu Leu Leu Glu Phe Gln Asn Glu Ser Arg Arg Leu Tyr Gln Phe
            180                 185                 190         
His Tyr Val Asn Trp Pro Asp His Asp Val Pro Ser Ser Phe Asp Ser
        195                 200                 205             
Ile Leu Asp Met Ile Ser Leu Met Arg Lys Tyr Gln Glu His Glu Asp
    210                 215                 220                 
Val Pro Ile Cys Ile His Cys Ser Ala Gly Cys Gly Arg Thr Gly Ala
225                 230                 235                 240 
Ile Cys Ala Ile Asp Tyr Thr Trp Asn Leu Leu Lys Ala Gly Lys Ile
                245                 250                 255     
Pro Glu Glu Phe Asn Val Phe Asn Leu Ile Gln Glu Met Arg Thr Gln
            260                 265                 270         
Arg His Ser Ala Val Gln Thr Lys Glu Gln Tyr Glu Leu Val His Arg
        275                 280                 285             
Ala Ile Ala Gln Leu Phe Glu Lys Gln Leu Gln Leu Tyr Glu Ile His
    290                 295                 300                 
Gly Ala Gln Lys Ile Ala Asp Gly Val Asn Glu Ile Asn Thr Glu Asn
305                 310                 315                 320 
Met Val Ser Ser Ile Glu Pro Glu Lys Gln Asp Ser Pro Pro Pro Lys
                325                 330                 335     
Pro Pro Arg Thr Arg Ser Cys Leu Val Glu Gly Asp Ala Lys Glu Glu
            340                 345                 350         
Ile Leu Gln Pro Pro Glu Pro His Pro Val Pro Pro Ile Leu Thr Pro
        355                 360                 365             
Ser Pro Pro Ser Ala Phe Pro Thr Val Thr Thr Val Trp Gln Asp Asn
    370                 375                 380                 
Asp Arg Tyr His Pro Lys Pro Val Leu His Met Val Ser Ser Glu Gln
385                 390                 395                 400 
His Ser Ala Asp Leu Asn Arg Asn Tyr Ser Lys Ser Thr Glu Leu Pro
                405                 410                 415     
Gly Lys Asn Glu Ser Thr Ile Glu Gln Ile Asp Lys Lys Leu Glu Arg
            420                 425                 430         
Asn Leu Ser Phe Glu Ile Lys Lys Val Pro Leu Gln Glu Gly Pro Lys
        435                 440                 445             
Ser Phe Asp Gly Asn Thr Leu Leu Asn Arg Gly His Ala Ile Lys Ile
    450                 455                 460                 
Lys Ser Ala Ser Pro Cys Ile Ala Asp Lys Ile Ser Lys Pro Gln Glu
465                 470                 475                 480 
Leu Ser Ser Asp Leu Asn Val Gly Asp Thr Ser Gln Asn Ser Cys Val
                485                 490                 495     
Asp Cys Ser Val Thr Gln Ser Asn Lys Val Ser Val Thr Pro Pro Glu
            500                 505                 510         
Glu Ser Gln Asn Ser Asp Thr Pro Pro Arg Pro Asp Arg Leu Pro Leu
        515                 520                 525             
Asp Glu Lys Gly His Val Thr Trp Ser Phe His Gly Pro Glu Asn Ala
    530                 535                 540                 
Ile Pro Ile Pro Asp Leu Ser Glu Gly Asn Ser Ser Asp Ile Asn Tyr
545                 550                 555                 560 
Gln Thr Arg Lys Thr Val Ser Leu Thr Pro Ser Pro Thr Thr Gln Val
                565                 570                 575     
Glu Thr Pro Asp Leu Val Asp His Asp Asn Thr Ser Pro Leu Phe Arg
            580                 585                 590         
Thr Pro Leu Ser Phe Thr Asn Pro Leu His Ser Asp Asp Ser Asp Ser
        595                 600                 605             
Asp Glu Arg Asn Ser Asp Gly Ala Val Thr Gln Asn Lys Thr Asn Ile
    610                 615                 620                 
Ser Thr Ala Ser Ala Thr Val Ser Ala Ala Thr Ser Thr Glu Ser Ile
625                 630                 635                 640 
Ser Thr Arg Lys Val Leu Pro Met Ser Ile Ala Arg His Asn Ile Ala
                645                 650                 655     
Gly Thr Thr His Ser Gly Ala Glu Lys Asp Val Asp Val Ser Glu Asp
            660                 665                 670         
Ser Pro Pro Pro Leu Pro Glu Arg Thr Pro Glu Ser Phe Val Leu Ala
        675                 680                 685             
Ser Glu His Asn Thr Pro Val Arg Ser Glu Trp Ser Glu Leu Gln Ser
    690                 695                 700                 
Gln Glu Arg Ser Glu Gln Lys Lys Ser Glu Gly Leu Ile Thr Ser Glu
705                 710                 715                 720 
Asn Glu Lys Cys Asp His Pro Ala Gly Gly Ile His Tyr Glu Met Cys
                725                 730                 735     
Ile Glu Cys Pro Pro Thr Phe Ser Asp Lys Arg Glu Gln Ile Ser Glu
            740                 745                 750         
Asn Pro Thr Glu Ala Thr Asp Ile Gly Phe Gly Asn Arg Cys Gly Lys
        755                 760                 765             
Pro Lys Gly Pro Arg Asp Pro Pro Ser Glu Trp Thr
    770                 775                 780 


<210> 6124
<211> 125
<212> PRT
<213> Homo sapiens

<400> 6124
Met Ile Val Thr Lys Ser Leu Val Met Leu Gln Pro Leu Gln Ile Ile
 1               5                  10                  15      
Gly Glu Ser Ile Met Lys Arg Asp Arg Thr Ser Val Ile Asp Val Ala
            20                  25                  30          
Asn Phe Ser Asp Ile Val His Thr Leu Gln Phe Ile Gly Glu Leu Ile
        35                  40                  45              
Val Glu Arg Asn Leu Thr Asn Val Lys Asn Val Met Lys Leu Ser Val
    50                  55                  60                  
Ser Asn Gln Thr Phe Lys Asp Ile Gly Glu Phe Ile Leu Glu Arg Asn
65                  70                  75                  80  
Leu Thr Gly Val Met Asn Val Ala Arg Pro Leu Val Gly Ser His Thr
                85                  90                  95      
Leu His Ala Ile Val Asp Phe Ile Leu Glu Arg Asn Leu Thr Ser Val
            100                 105                 110         
Met Ser Val Ala Arg Pro Ser Val Glu Ile Gln Pro Leu
        115                 120                 125 


<210> 6125
<211> 1368
<212> PRT
<213> Homo sapiens

<400> 6125
Gln Tyr Val Leu Leu Ile Pro Ser Val Leu Gln Glu Gly Ser Leu Asp
 1               5                  10                  15      
Lys Ala Cys Ala Gln Leu Phe Asn Leu Thr Glu Ser Val Val Leu Thr
            20                  25                  30          
Val Ser Leu Asn Tyr Gly Glu Val Gln Thr Lys Ile Phe Glu Glu Asn
        35                  40                  45              
Val Thr Gly Glu Asn Phe Phe Lys Cys Ile Ser Phe Glu Val Pro Gln
    50                  55                  60                  
Ala Arg Ser Asp Pro Leu Ala Phe Ile Thr Phe Ser Ala Lys Gly Ala
65                  70                  75                  80  
Thr Leu Asn Leu Glu Glu Arg Arg Ser Val Ala Ile Arg Ser Arg Glu
                85                  90                  95      
Asn Val Val Phe Val Gln Thr Asp Lys Pro Thr Tyr Lys Pro Gly Gln
            100                 105                 110         
Lys Ala Cys Lys Asn Thr Leu Ser Tyr Ser Gln Asp Pro Glu Gly Asn
        115                 120                 125             
Arg Ile Gln Gln Trp Val Asn Glu Glu Ser Val Gly Gly Ile Leu Gln
    130                 135                 140                 
Leu Ser Phe Gln Leu Ile Ser Glu Pro Ile Leu Gly Trp Tyr Glu Ile
145                 150                 155                 160 
Thr Val Glu Met Leu Asn Glu Lys Lys Thr Tyr His Ser Phe Ser Val
                165                 170                 175     
Glu Glu Tyr Val Leu Pro Lys Phe Glu Val Thr Val Asn Ala Pro Gln
            180                 185                 190         
Thr Val Thr Ile Ser Asp Asp Glu Phe Gln Val Asp Val Cys Ala Lys
        195                 200                 205             
Tyr Thr Phe Gly Gln Pro Val Gln Gly Lys Thr Gln Ile Arg Val Cys
    210                 215                 220                 
Arg Glu Tyr Phe Ser Ser Ser Asn Cys Glu Lys Asn Asp Asn Glu Ile
225                 230                 235                 240 
Cys Glu Gln Phe Ile Ala Gln Leu Glu Asn Gly Cys Val Ser Gln Ile
                245                 250                 255     
Val Asn Thr Lys Val Phe Gln Leu Tyr Arg Ser Gly Leu Phe Met Thr
            260                 265                 270         
Phe His Val Ala Val Ile Val Thr Glu Phe Gly Thr Gly Asn Tyr Cys
        275                 280                 285             
Met Gln Ile Ser Glu Lys Thr Ser Val Phe Ile Thr Gln Leu Leu Gly
    290                 295                 300                 
Thr Val Asn Phe Glu Asn Met Asp Thr Phe Tyr Arg Arg Gly Ile Ser
305                 310                 315                 320 
Tyr Phe Gly Thr Leu Lys Phe Ser Asp Pro Asn Asn Val Pro Met Val
                325                 330                 335     
Asn Lys Leu Leu Gln Leu Glu Leu Asn Asp Glu Phe Ile Gly Asn Tyr
            340                 345                 350         
Thr Thr Asp Glu Asn Gly Glu Ala Gln Phe Ser Ile Asp Thr Ser Asp
        355                 360                 365             
Ile Phe Asp Pro Glu Phe Asn Leu Lys Ala Thr Tyr Val Arg Pro Lys
    370                 375                 380                 
Ser Cys Tyr Leu Pro Ser Trp Leu Thr Pro Gln Tyr Leu Asp Ala His
385                 390                 395                 400 
Phe Leu Val Ser Arg Phe Tyr Ser Arg Thr Asn Ser Phe Leu Lys Ile
                405                 410                 415     
Val Pro Glu Pro Lys Gln Leu Glu Cys Asn His Gln Lys Val Val Thr
            420                 425                 430         
Val His Tyr Ser Leu Asn Ser Glu Ala Tyr Glu Asp Asp Ser Asn Val
        435                 440                 445             
Lys Phe Phe Tyr Leu Val Ser Leu Arg Asn Phe Gln His Arg Ile Ser
    450                 455                 460                 
Ser Ser Pro Ile Tyr Thr Ala Trp Asn Gly Asn Phe Ser Phe Pro Leu
465                 470                 475                 480 
Ser Ile Ser Ala Asp Leu Ala Pro Ala Ala Val Leu Phe Val Tyr Thr
                485                 490                 495     
Leu His Pro Ser Gly Glu Ile Val Ala Asp Ser Val Arg Phe Gln Val
            500                 505                 510         
Asp Lys Cys Phe Lys His Lys Val Asn Ile Lys Phe Ser Asn Glu Gln
        515                 520                 525             
Gly Leu Pro Gly Ser Asn Ala Ser Leu Tyr Leu Gln Ala Ala Pro Val
    530                 535                 540                 
Leu Phe Cys Ala Leu Gly Ala Val Asp Gly Asn Val Leu Leu Leu Lys
545                 550                 555                 560 
Ser Glu Gln Gln Leu Ser Ala Glu Ser Val Tyr Asn Met Val Pro Ser
                565                 570                 575     
Ile Glu Pro Tyr Gly Tyr Phe Tyr His Gly Leu Asn Leu Asp Asp Gly
            580                 585                 590         
Lys Glu Asp Pro Cys Ile Pro Gln Arg Asp Met Phe Tyr Asn Gly Leu
        595                 600                 605             
Tyr Tyr Thr Pro Val Ser Asn Tyr Gly Asp Gly Asp Ile Tyr Asn Ile
    610                 615                 620                 
Val Arg Asn Met Gly Leu Lys Val Phe Thr Asn Leu His Tyr Arg Lys
625                 630                 635                 640 
Pro Glu Val Cys Val Met Glu Arg Arg Leu Pro Leu Pro Lys Pro Leu
                645                 650                 655     
Tyr Leu Glu Thr Glu Asn Tyr Gly Pro Met His Ser Val Pro Ser Arg
            660                 665                 670         
Ile Ala Cys Arg Gly Glu Asn Ala Asp Tyr Val Glu Gln Ala Ile Ile
        675                 680                 685             
Gln Thr Val Arg Thr Asn Phe Pro Glu Thr Trp Met Trp Asp Leu Val
    690                 695                 700                 
Ser Val Asp Ser Ser Gly Ser Ala Asn Leu Ser Phe Leu Ile Pro Asp
705                 710                 715                 720 
Thr Ile Thr Gln Trp Glu Ala Ser Gly Phe Cys Val Asn Gly Asp Val
                725                 730                 735     
Gly Phe Gly Ile Ser Ser Thr Thr Thr Leu Glu Val Ser Gln Pro Phe
            740                 745                 750         
Phe Ile Glu Ile Ala Ser Pro Phe Ser Val Val Gln Asn Glu Gln Phe
        755                 760                 765             
Asp Leu Ile Val Asn Ala Phe Ser Tyr Leu Asn Thr Cys Val Glu Ile
    770                 775                 780                 
Ser Val Gln Val Glu Glu Ser Gln Asn Tyr Glu Ala Asn Ile Asn Thr
785                 790                 795                 800 
Trp Lys Ile Asn Gly Ser Glu Val Ile Gln Ala Gly Gly Arg Lys Thr
                805                 810                 815     
Asn Ile Trp Thr Ile Ile Pro Lys Lys Leu Gly Lys Val Asn Ile Thr
            820                 825                 830         
Val Val Ala Glu Ser Lys Gln Ser Ser Ala Cys Pro Asn Glu Gly Met
        835                 840                 845             
Glu Gln Gln Lys Leu Asn Trp Lys Asp Thr Val Val Lys Ser Phe Leu
    850                 855                 860                 
Val Glu Pro Glu Gly Ile Glu Lys Glu Arg Thr Gln Ser Phe Leu Ile
865                 870                 875                 880 
Cys Thr Glu Gly Ala Lys Ala Ser Lys Gln Gly Val Leu Asp Leu Pro
                885                 890                 895     
Asn Asp Val Val Glu Gly Ser Ala Arg Gly Phe Phe Thr Val Val Gly
            900                 905                 910         
Asp Ile Leu Gly Leu Ala Met Gln Asn Leu Val Val Leu Gln Met Pro
        915                 920                 925             
Tyr Gly Gly Gly Glu Gln Asn Ala Ala Leu Leu Ala Ser Asp Thr Tyr
    930                 935                 940                 
Val Leu Asp Tyr Leu Lys Ser Thr Glu Gln Leu Thr Glu Glu Val Gln
945                 950                 955                 960 
Ser Lys Ala Phe Phe Leu Leu Ser Asn Gly Tyr Gln Arg Gln Leu Ser
                965                 970                 975     
Phe Lys Asn Ser Asp Gly Ser Tyr Ser Val Phe Trp Gln Gln Asn Gln
            980                 985                 990         
Lys Gly Ser Ile Trp Leu Ser Ala Leu Thr Phe Lys Thr Leu Glu Arg
        995                 1000                1005            
Met Lys Lys Phe Val Phe Ile Asp Glu Asn Val Gln Lys Gln Thr Leu
    1010                1015                1020                
Ile Trp Leu Ser Ser Gln Gln Lys Thr Ser Gly Cys Phe Lys Asn Asp
1025                1030                1035                1040
Gly Gln Leu Phe Asn His Ala Trp Glu Gly Gly Asp Glu Glu Asp Ile
                1045                1050                1055    
Ser Leu Thr Ala Tyr Val Val Gly Met Phe Phe Glu Ala Gly Leu Asn
            1060                1065                1070        
Ser Thr Phe Pro Ala Leu Arg Asn Ala Leu Phe Cys Leu Glu Ala Ala
        1075                1080                1085            
Leu Asp Ser Gly Val Thr Asn Gly Tyr Asn His Ala Ile Leu Ala Tyr
    1090                1095                1100                
Ala Phe Ala Leu Ala Gly Lys Glu Lys Gln Val Glu Ser Leu Leu Gln
1105                1110                1115                1120
Thr Leu Asp Gln Ser Ala Thr Lys Leu Asn Asn Val Ile Tyr Trp Glu
                1125                1130                1135    
Arg Glu Arg Lys Pro Lys Thr Glu Glu Phe Pro Ser Phe Ile Pro Trp
            1140                1145                1150        
Ala Pro Ser Ala Gln Thr Glu Lys Ser Cys Tyr Val Leu Leu Ala Val
        1155                1160                1165            
Ile Ser Arg Lys Ile Pro Asp Leu Thr Tyr Ala Ser Lys Ile Val Gln
    1170                1175                1180                
Trp Leu Ala Gln Gln Met Asn Ser His Gly Gly Phe Ser Ser Asn Gln
1185                1190                1195                1200
Val Ile Asn Val Gly Leu Ile Leu Ile Ala Ile Cys Gly Glu Glu Gly
                1205                1210                1215    
Leu Phe Ser Lys Asn Gln Asn Thr Val Thr Phe Ser Ser Glu Gly Ser
            1220                1225                1230        
Ser Glu Ile Gln Phe Asn Gly His Asn Arg Leu Leu Val Gln Arg Ser
        1235                1240                1245            
Glu Val Thr Gln Ala Pro Gly Gln Tyr Thr Val Asp Val Glu Gly Arg
    1250                1255                1260                
Gly Cys Thr Phe Ile Gln Ala Thr Leu Lys Tyr Asn Val Leu Leu Pro
1265                1270                1275                1280
Lys Lys Ala Ser Gly Phe Ser Leu Ser Leu Glu Ile Val Lys Asn Tyr
                1285                1290                1295    
Ser Leu Thr Val Phe Asp Leu Thr Val Asn Leu Lys Tyr Thr Gly Ile
            1300                1305                1310        
Arg Asn Lys Ser Ser Met Val Val Ile Asp Val Lys Met Leu Ser Gly
        1315                1320                1325            
Phe Thr Pro Thr Met Ser Ser Ile Glu Glu Leu Glu Asn Lys Gly Gln
    1330                1335                1340                
Val Met Lys Thr Glu Val Lys Asn Asp His Val Leu Phe Tyr Leu Glu
1345                1350                1355                1360
Asn Val Ser Leu Ala Ile Phe Phe
                1365            


<210> 6126
<211> 456
<212> PRT
<213> Homo sapiens

<400> 6126
Met Arg Gly Ala Met Glu Leu Glu Pro Glu Leu Leu Leu Gln Glu Ala
 1               5                  10                  15      
Arg Glu Asn Val Glu Ala Ala Gln Ser Tyr Arg Arg Glu Leu Gly His
            20                  25                  30          
Arg Leu Glu Gly Leu Arg Glu Ala Arg Arg Gln Ile Lys Glu Ser Ala
        35                  40                  45              
Ser Gln Thr Arg Asp Val Leu Lys Gln His Phe Asn Asp Leu Lys Gly
    50                  55                  60                  
Thr Leu Gly Lys Leu Leu Asp Glu Arg Leu Val Thr Leu Leu Gln Glu
65                  70                  75                  80  
Val Asp Thr Ile Glu Gln Glu Thr Ile Lys Pro Leu Asp Asp Cys Gln
                85                  90                  95      
Lys Leu Ile Glu His Gly Val Asn Thr Ala Glu Asp Leu Val Arg Glu
            100                 105                 110         
Gly Glu Ile Ala Met Leu Gly Gly Val Gly Glu Glu Asn Glu Lys Leu
        115                 120                 125             
Trp Ser Phe Thr Lys Lys Ala Ser His Ile Gln Leu Asp Ser Leu Pro
    130                 135                 140                 
Glu Val Pro Leu Leu Val Asp Val Pro Cys Leu Ser Ala Gln Leu Asp
145                 150                 155                 160 
Asp Ser Ile Leu Asn Ile Val Lys Asp His Ile Phe Lys His Gly Thr
                165                 170                 175     
Val Ala Ser Arg Pro Pro Val Gln Ile Glu Glu Leu Ile Glu Lys Pro
            180                 185                 190         
Gly Gly Ile Ile Val Arg Trp Cys Lys Val Asp Asp Asp Phe Thr Ala
        195                 200                 205             
Gln Asp Tyr Arg Leu Gln Phe Arg Lys Cys Thr Ser Asn His Phe Glu
    210                 215                 220                 
Asp Val Tyr Val Gly Ser Glu Thr Glu Phe Ile Val Leu His Ile Asp
225                 230                 235                 240 
Pro Asn Val Asp Tyr Gln Phe Arg Val Cys Ala Arg Gly Asp Gly Arg
                245                 250                 255     
Gln Glu Trp Ser Pro Trp Ser Val Pro Gln Ile Gly His Ser Thr Leu
            260                 265                 270         
Val Pro His Glu Trp Thr Ala Gly Phe Glu Gly Tyr Ser Leu Ser Ser
        275                 280                 285             
Arg Arg Asn Ile Ala Leu Arg Asn Asp Ser Glu Ser Ser Gly Val Leu
    290                 295                 300                 
Tyr Ser Arg Ala Pro Thr Tyr Phe Cys Gly Gln Thr Leu Thr Phe Arg
305                 310                 315                 320 
Gln Val Asp Ile Lys Thr Ser His Leu Pro Gln Glu Ala Glu Val Glu
                325                 330                 335     
Thr Val Gly Gln Pro Asp Arg Arg Asp Ser Ile Gly Val Cys Ala Glu
            340                 345                 350         
Lys Gln Asp Gly Tyr Asp Ser Leu Gln Arg Asp Gln Ala Val Cys Ile
        355                 360                 365             
Ser Thr Asn Gly Ala Val Phe Val Asn Gly Lys Glu Met Thr Asn Gln
    370                 375                 380                 
Leu Pro Ala Val Thr Ser Gly Ser Thr Val Thr Phe Asp Ile Glu Ala
385                 390                 395                 400 
Val Thr Leu Gly Thr Thr Ser Asn Asn Glu Gly Gly His Phe Lys Leu
                405                 410                 415     
Arg Val Thr Ile Ser Ser Asn Asn Arg Glu Val Val Phe Asp Trp Leu
            420                 425                 430         
Leu Asp Gln Ser Cys Gly Ser Leu Tyr Phe Gly Cys Ser Phe Phe Tyr
        435                 440                 445             
Pro Gly Trp Lys Val Leu Val Phe
    450                 455     


<210> 6127
<211> 747
<212> PRT
<213> Homo sapiens

<400> 6127
Met Ala Glu Ala Val Glu Arg Thr Asp Glu Leu Val Arg Glu Tyr Leu
 1               5                  10                  15      
Leu Phe Arg Gly Phe Thr His Thr Leu Arg Gln Leu Asp Ala Glu Ile
            20                  25                  30          
Lys Ala Asp Lys Glu Lys Gly Phe Arg Val Asp Lys Ile Val Asp Gln
        35                  40                  45              
Leu Gln Gln Leu Met Gln Val Tyr Asp Leu Ala Ala Leu Arg Asp Tyr
    50                  55                  60                  
Trp Ser Tyr Leu Glu Arg Arg Leu Phe Ser Arg Leu Glu Asp Ile Tyr
65                  70                  75                  80  
Arg Pro Thr Ile His Lys Leu Lys Thr Ser Leu Phe Arg Phe Tyr Leu
                85                  90                  95      
Val Tyr Thr Ile Gln Thr Asn Arg Asn Asp Lys Ala Gln Glu Phe Phe
            100                 105                 110         
Ala Lys Gln Ala Thr Glu Leu Gln Asn Gln Ala Glu Trp Lys Asp Trp
        115                 120                 125             
Phe Val Leu Pro Phe Leu Pro Ser Pro Asp Thr Asn Pro Thr Phe Ala
    130                 135                 140                 
Thr Tyr Phe Ser Arg Gln Trp Ala Asp Thr Phe Ile Val Ser Leu His
145                 150                 155                 160 
Asn Phe Leu Ser Val Leu Phe Gln Cys Met Pro Val Pro Val Ile Leu
                165                 170                 175     
Asn Phe Asp Ala Glu Cys Gln Arg Thr Asn Gln Val Gln Glu Glu Asn
            180                 185                 190         
Glu Val Leu Arg Gln Lys Leu Phe Ala Leu Gln Ala Glu Ile His Arg
        195                 200                 205             
Leu Lys Lys Glu Glu Gln Gln Pro Glu Glu Glu Glu Ala Leu Val Gln
    210                 215                 220                 
His Lys Leu Pro Pro Tyr Val Ser Asn Met Asp Arg Leu Gly Asp Ser
225                 230                 235                 240 
Glu Leu Ala Met Val Cys Ser Gln Arg Asn Ala Ser Leu Ser Gln Ser
                245                 250                 255     
Pro Arg Val Gly Phe Leu Ser Ser Leu Leu Pro Gln Ser Lys Lys Ser
            260                 265                 270         
Pro Ser Arg Leu Ser Pro Ala Gln Gly Pro Pro Gln Pro Gln Ser Ser
        275                 280                 285             
Ala Lys Lys Glu Ser Phe Gly Gly Gln Gly Thr Lys Gly Lys Asp Pro
    290                 295                 300                 
Thr Ser Gly Ala Lys Asp Gly Lys Ser Leu Leu Ser Gly Leu Ala Thr
305                 310                 315                 320 
Gly Glu Ser Gly Trp Ser Gln His Arg Gln Arg Arg Leu Gln Asp His
                325                 330                 335     
Gly Lys Glu Arg Lys Glu Leu Phe Ser Thr Thr Thr Ser Gln Cys Ala
            340                 345                 350         
Glu Lys Lys Pro Glu Ala Ser Gly Pro Glu Ala Glu Pro Cys Pro Glu
        355                 360                 365             
Leu His Thr Glu Pro Val Glu Pro Leu Thr Arg Ala Ser Ser Ala Gly
    370                 375                 380                 
Pro Glu Gly Gly Gly Val Arg Pro Glu Gln Pro Phe Ile Val Leu Gly
385                 390                 395                 400 
Gln Glu Glu Tyr Gly Glu His His Ser Ser Ile Met His Cys Arg Val
                405                 410                 415     
Asp Cys Ser Gly Arg Arg Val Ala Ser Leu Asp Val Asp Gly Val Ile
            420                 425                 430         
Lys Val Trp Ser Phe Asn Pro Ile Met Gln Thr Lys Ala Ser Ser Ile
        435                 440                 445             
Ser Lys Ser Pro Leu Leu Ser Leu Glu Trp Ala Thr Lys Arg Asp Arg
    450                 455                 460                 
Leu Leu Leu Leu Gly Ser Gly Val Gly Thr Val Arg Leu Tyr Asp Thr
465                 470                 475                 480 
Glu Ala Lys Lys Asn Leu Cys Glu Ile Asn Ile Asn Asp Asn Met Pro
                485                 490                 495     
Arg Ile Leu Ser Leu Ala Cys Ser Pro Asn Gly Ala Ser Phe Val Cys
            500                 505                 510         
Ser Ala Ala Ala Pro Ser Leu Thr Ser Gln Val Asp Phe Ser Ala Pro
        515                 520                 525             
Asp Ile Gly Ser Lys Gly Met Asn Gln Val Pro Gly Arg Leu Leu Leu
    530                 535                 540                 
Trp Asp Thr Lys Thr Met Lys Gln Gln Leu Gln Phe Ser Leu Asp Pro
545                 550                 555                 560 
Glu Pro Ile Ala Ile Asn Cys Thr Ala Phe Asn His Asn Gly Asn Leu
                565                 570                 575     
Leu Val Thr Gly Ala Ala Asp Gly Val Ile Arg Leu Phe Asp Met Gln
            580                 585                 590         
Gln His Glu Cys Ala Met Ser Trp Arg Ala His Tyr Gly Glu Val Tyr
        595                 600                 605             
Ser Val Glu Phe Ser Tyr Asp Glu Asn Thr Val Tyr Ser Ile Gly Glu
    610                 615                 620                 
Asp Gly Lys Phe Ile Gln Trp Asn Ile His Lys Ser Gly Leu Lys Val
625                 630                 635                 640 
Ser Glu Tyr Ser Leu Pro Ser Asp Ala Thr Gly Pro Phe Val Leu Ser
                645                 650                 655     
Gly Tyr Ser Gly Tyr Lys Gln Val Gln Val Pro Arg Gly Arg Leu Phe
            660                 665                 670         
Ala Phe Asp Ser Glu Gly Asn Tyr Met Leu Thr Cys Ser Ala Thr Gly
        675                 680                 685             
Gly Val Ile Tyr Lys Leu Gly Gly Asp Glu Lys Val Leu Glu Ser Cys
    690                 695                 700                 
Leu Ser Leu Gly Gly His Arg Ala Pro Val Val Thr Val Asp Trp Ser
705                 710                 715                 720 
Thr Ala Met Asp Cys Gly Thr Cys Leu Thr Ala Ser Met Asp Gly Lys
                725                 730                 735     
Ile Lys Leu Thr Thr Leu Leu Ala His Lys Ala
            740                 745         


<210> 6128
<211> 636
<212> PRT
<213> Homo sapiens

<400> 6128
Met Ala Glu Ala Val Glu Arg Thr Asp Glu Leu Val Arg Glu Tyr Leu
 1               5                  10                  15      
Leu Phe Arg Gly Phe Thr His Thr Leu Arg Gln Leu Asp Ala Glu Ile
            20                  25                  30          
Lys Ala Asp Lys Glu Lys Gly Phe Arg Val Asp Lys Ile Val Asp Gln
        35                  40                  45              
Leu Gln Gln Leu Met Gln Val Tyr Asp Leu Ala Ala Leu Arg Asp Tyr
    50                  55                  60                  
Trp Ser Tyr Leu Glu Arg Arg Leu Phe Ser Arg Leu Glu Asp Ile Tyr
65                  70                  75                  80  
Arg Pro Thr Ile His Lys Leu Lys Thr Ser Leu Phe Arg Phe Tyr Leu
                85                  90                  95      
Val Tyr Thr Ile Gln Thr Asn Arg Asn Asp Lys Ala Gln Glu Phe Phe
            100                 105                 110         
Ala Lys Gln Ala Thr Glu Leu Gln Asn Gln Ala Glu Trp Lys Asp Trp
        115                 120                 125             
Phe Val Leu Pro Phe Leu Pro Ser Pro Asp Thr Asn Pro Thr Phe Ala
    130                 135                 140                 
Thr Tyr Phe Ser Arg Gln Trp Ala Asp Thr Phe Ile Val Ser Leu His
145                 150                 155                 160 
Asn Phe Leu Ser Val Leu Phe Gln Cys Met Pro Val Pro Val Ile Leu
                165                 170                 175     
Asn Phe Asp Ala Glu Cys Gln Arg Thr Asn Gln Val Gln Glu Glu Asn
            180                 185                 190         
Glu Val Leu Arg Gln Lys Leu Phe Ala Leu Gln Ala Glu Ile His Arg
        195                 200                 205             
Leu Lys Lys Glu Glu Gln Gln Pro Glu Glu Glu Glu Ala Leu Val Gln
    210                 215                 220                 
His Lys Leu Pro Pro Tyr Val Ser Asn Met Asp Arg Leu Gly Asp Ser
225                 230                 235                 240 
Glu Leu Ala Met Val Cys Ser Gln Arg Asn Ala Ser Leu Ser Gln Ser
                245                 250                 255     
Pro Arg Val Gly Phe Leu Ser Ser Leu Leu Pro Gln Ser Lys Lys Ser
            260                 265                 270         
Pro Ser Arg Leu Ser Pro Ala Gln Gly Pro Pro Gln Pro Gln Ser Ser
        275                 280                 285             
Ala Lys Lys Glu Ser Phe Gly Gly Gln Gly Thr Lys Gly Lys Asp Pro
    290                 295                 300                 
Thr Ser Gly Ala Lys Asp Gly Lys Ser Leu Leu Ser Gly Leu Ala Thr
305                 310                 315                 320 
Gly Glu Ser Gly Trp Ser Gln His Arg Gln Arg Arg Leu Gln Asp His
                325                 330                 335     
Gly Lys Glu Arg Lys Glu Leu Phe Ser Thr Thr Thr Ser Gln Cys Ala
            340                 345                 350         
Glu Lys Lys Pro Glu Ala Ser Gly Pro Glu Ala Glu Pro Cys Pro Glu
        355                 360                 365             
Leu His Thr Glu Pro Val Glu Pro Leu Thr Arg Ala Ser Ser Ala Gly
    370                 375                 380                 
Pro Glu Gly Gly Gly Val Arg Pro Glu Gln Pro Phe Ile Val Leu Gly
385                 390                 395                 400 
Gln Glu Glu Tyr Gly Glu His His Ser Ser Ile Met His Cys Arg Val
                405                 410                 415     
Asp Cys Ser Gly Arg Arg Val Ala Ser Leu Asp Val Asp Gly Val Ile
            420                 425                 430         
Lys Val Trp Ser Phe Asn Pro Ile Met Gln Thr Lys Ala Ser Ser Ile
        435                 440                 445             
Ser Lys Ser Pro Leu Leu Ser Leu Glu Trp Ala Thr Lys Arg Asp Arg
    450                 455                 460                 
Leu Leu Leu Leu Gly Ser Gly Val Gly Thr Val Arg Leu Tyr Asp Thr
465                 470                 475                 480 
Glu Ala Lys Lys Asn Leu Cys Glu Ile Asn Ile Asn Asp Asn Met Pro
                485                 490                 495     
Arg Ile Leu Ser Leu Ala Cys Ser Pro Asn Gly Ala Ser Phe Val Cys
            500                 505                 510         
Ser Ala Ala Ala Pro Ser Leu Thr Ser Gln Val Asp Phe Ser Ala Pro
        515                 520                 525             
Asp Ile Gly Ser Lys Gly Met Asn Gln Val Pro Gly Arg Leu Leu Leu
    530                 535                 540                 
Trp Asp Thr Lys Thr Met Lys Gln Gln Leu Gln Phe Ser Leu Asp Pro
545                 550                 555                 560 
Glu Pro Ile Ala Ile Asn Cys Thr Ala Phe Asn His Asn Gly Asn Leu
                565                 570                 575     
Leu Val Thr Gly Ala Ala Asp Gly Val Ile Arg Leu Phe Val His Pro
            580                 585                 590         
Val Glu His Pro Gln Glu Trp Pro Gln Gly Ile Arg Val Gln Pro Pro
        595                 600                 605             
Leu Arg Cys His Gly Pro Leu Cys Ala Val Trp Ile Gln Arg Leu Gln
    610                 615                 620                 
Ala Gly Ser Ser Pro Gln Gly Pro Thr Leu Arg Phe
625                 630                 635     


<210> 6129
<211> 950
<212> PRT
<213> Homo sapiens

<400> 6129
Met Gly Val Pro Ala Phe Phe Arg Trp Leu Ser Arg Lys Tyr Pro Ser
 1               5                  10                  15      
Ile Ile Val Asn Cys Val Glu Glu Lys Pro Lys Glu Cys Asn Gly Val
            20                  25                  30          
Lys Ile Pro Val Asp Ala Ser Lys Pro Asn Pro Asn Asp Val Glu Phe
        35                  40                  45              
Asp Asn Leu Tyr Leu Asp Met Asn Gly Ile Ile His Pro Cys Thr His
    50                  55                  60                  
Pro Glu Asp Lys Pro Ala Pro Lys Asn Glu Asp Glu Met Met Val Ala
65                  70                  75                  80  
Ile Phe Glu Tyr Ile Asp Arg Leu Phe Ser Ile Val Arg Pro Arg Arg
                85                  90                  95      
Leu Leu Tyr Met Ala Ile Asp Gly Val Ala Pro Arg Ala Lys Met Asn
            100                 105                 110         
Gln Gln Arg Ser Arg Arg Phe Arg Ala Ser Lys Glu Gly Met Glu Ala
        115                 120                 125             
Ala Val Glu Lys Gln Arg Val Arg Glu Glu Ile Leu Ala Lys Gly Gly
    130                 135                 140                 
Phe Leu Pro Pro Glu Glu Ile Lys Glu Arg Phe Asp Ser Asn Cys Ile
145                 150                 155                 160 
Thr Pro Gly Thr Glu Phe Met Asp Asn Leu Ala Lys Cys Leu Arg Tyr
                165                 170                 175     
Tyr Ile Ala Asp Arg Leu Asn Asn Asp Pro Gly Trp Lys Asn Leu Thr
            180                 185                 190         
Val Ile Leu Ser Asp Ala Ser Ala Pro Gly Glu Gly Glu His Lys Ile
        195                 200                 205             
Met Asp Tyr Ile Arg Arg Gln Arg Ala Gln Pro Asn His Asp Pro Asn
    210                 215                 220                 
Thr His His Cys Leu Cys Gly Ala Asp Ala Asp Leu Ile Met Leu Gly
225                 230                 235                 240 
Leu Ala Thr His Glu Pro Asn Phe Thr Ile Ile Arg Glu Glu Phe Lys
                245                 250                 255     
Pro Asn Lys Pro Lys Pro Cys Gly Leu Cys Asn Gln Phe Gly His Glu
            260                 265                 270         
Val Lys Asp Cys Glu Gly Leu Pro Arg Glu Lys Lys Gly Lys His Asp
        275                 280                 285             
Glu Leu Ala Asp Ser Leu Pro Cys Ala Glu Gly Glu Phe Ile Phe Leu
    290                 295                 300                 
Arg Leu Asn Val Leu Arg Glu Tyr Leu Glu Arg Glu Leu Thr Met Ala
305                 310                 315                 320 
Ser Leu Pro Phe Thr Phe Asp Val Glu Arg Ser Ile Asp Asp Trp Val
                325                 330                 335     
Phe Met Cys Phe Phe Val Gly Asn Asp Phe Leu Pro His Leu Pro Ser
            340                 345                 350         
Leu Glu Ile Arg Glu Asn Ala Ile Asp Arg Leu Val Asn Ile Tyr Lys
        355                 360                 365             
Asn Val Val His Lys Thr Gly Gly Tyr Leu Thr Glu Ser Gly Tyr Val
    370                 375                 380                 
Asn Leu Gln Arg Val Gln Met Ile Met Leu Ala Val Gly Glu Val Glu
385                 390                 395                 400 
Asp Ser Ile Phe Lys Lys Arg Lys Asp Asp Glu Asp Ser Phe Arg Arg
                405                 410                 415     
Arg Gln Lys Glu Lys Arg Lys Arg Met Lys Arg Asp Gln Pro Ala Phe
            420                 425                 430         
Thr Pro Ser Gly Ile Leu Thr Pro His Ala Leu Gly Ser Arg Asn Ser
        435                 440                 445             
Pro Gly Ser Gln Val Ala Ser Asn Pro Arg Gln Ala Ala Tyr Glu Met
    450                 455                 460                 
Arg Met Gln Asn Asn Ser Ser Pro Ser Ile Ser Pro Asn Thr Ser Phe
465                 470                 475                 480 
Thr Ser Asp Gly Ser Pro Ser Pro Leu Gly Gly Ile Lys Arg Lys Ala
                485                 490                 495     
Glu Asp Ser Asp Ser Glu Pro Glu Pro Glu Asp Asn Val Arg Leu Trp
            500                 505                 510         
Glu Ala Gly Trp Lys Gln Arg Tyr Tyr Lys Asn Lys Phe Asp Val Asp
        515                 520                 525             
Ala Ala Asp Glu Lys Phe Arg Arg Lys Val Val Gln Ser Tyr Val Glu
    530                 535                 540                 
Gly Leu Cys Trp Val Leu Arg Tyr Tyr Tyr Gln Gly Cys Ala Ser Trp
545                 550                 555                 560 
Lys Trp Tyr Tyr Pro Phe His Tyr Ala Pro Phe Ala Ser Asp Phe Glu
                565                 570                 575     
Gly Ile Ala Asp Met Pro Ser Asp Phe Glu Lys Gly Thr Lys Pro Phe
            580                 585                 590         
Lys Pro Leu Glu Gln Leu Met Gly Val Phe Pro Ala Ala Ser Gly Asn
        595                 600                 605             
Phe Leu Pro Pro Ser Trp Arg Lys Leu Met Ser Asp Pro Asp Ser Ser
    610                 615                 620                 
Ile Ile Asp Phe Tyr Pro Glu Asp Phe Ala Ile Asp Leu Asn Gly Lys
625                 630                 635                 640 
Lys Tyr Ala Trp Gln Gly Val Ala Leu Leu Pro Phe Val Asp Glu Arg
                645                 650                 655     
Arg Leu Arg Ala Ala Leu Glu Glu Val Tyr Pro Asp Leu Thr Pro Glu
            660                 665                 670         
Glu Thr Arg Arg Asn Ser Leu Gly Gly Asp Val Leu Phe Val Gly Lys
        675                 680                 685             
His His Pro Leu His Asp Phe Ile Leu Glu Leu Tyr Gln Thr Gly Ser
    690                 695                 700                 
Thr Glu Pro Val Glu Val Pro Pro Glu Leu Cys His Gly Ile Gln Gly
705                 710                 715                 720 
Lys Phe Ser Leu Asp Glu Glu Ala Ile Leu Pro Asp Gln Ile Val Cys
                725                 730                 735     
Ser Pro Val Pro Met Leu Arg Asp Leu Thr Gln Asn Thr Val Val Ser
            740                 745                 750         
Ile Asn Phe Lys Asp Pro Gln Phe Ala Glu Asp Tyr Ile Phe Lys Ala
        755                 760                 765             
Val Met Leu Pro Gly Ala Arg Lys Pro Ala Ala Val Leu Lys Pro Ser
    770                 775                 780                 
Asp Trp Glu Lys Ser Ser Asn Gly Arg Gln Trp Lys Pro Gln Leu Gly
785                 790                 795                 800 
Phe Asn Arg Asp Arg Arg Pro Val His Leu Asp Gln Ala Ala Phe Arg
                805                 810                 815     
Thr Leu Gly His Val Met Pro Arg Gly Ser Gly Thr Gly Ile Tyr Ser
            820                 825                 830         
Asn Ala Ala Pro Pro Pro Val Thr Tyr Gln Gly Asn Leu Tyr Arg Pro
        835                 840                 845             
Leu Leu Arg Gly Gln Ala Gln Ile Pro Lys Leu Met Ser Asn Met Arg
    850                 855                 860                 
Pro Gln Asp Ser Trp Arg Gly Pro Pro Pro Leu Phe Gln Gln Gln Arg
865                 870                 875                 880 
Phe Asp Arg Gly Val Gly Ala Glu Pro Leu Leu Pro Trp Asn Arg Met
                885                 890                 895     
Leu Gln Thr Gln Asn Ala Ala Phe Gln Pro Asn Gln Tyr Gln Met Leu
            900                 905                 910         
Ala Gly Pro Gly Gly Tyr Pro Pro Arg Arg Asp Asp Arg Gly Gly Arg
        915                 920                 925             
Gln Gly Tyr Pro Arg Glu Gly Arg Lys Tyr Pro Leu Pro Pro Pro Ser
    930                 935                 940                 
Gly Arg Tyr Asn Trp Asn
945                 950 


<210> 6130
<211> 648
<212> PRT
<213> Homo sapiens

<400> 6130
Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly
 1               5                  10                  15      
Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile
            20                  25                  30          
Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu
        35                  40                  45              
Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn
    50                  55                  60                  
Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp
65                  70                  75                  80  
Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys
                85                  90                  95      
Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu
            100                 105                 110         
Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val
        115                 120                 125             
Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys
    130                 135                 140                 
Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu
145                 150                 155                 160 
Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys
                165                 170                 175     
Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln
            180                 185                 190         
Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala
        195                 200                 205             
Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met
    210                 215                 220                 
Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe
225                 230                 235                 240 
Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg
                245                 250                 255     
Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val
            260                 265                 270         
Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala
        275                 280                 285             
Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly
    290                 295                 300                 
Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro
305                 310                 315                 320 
Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg
                325                 330                 335     
Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser
            340                 345                 350         
Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp
        355                 360                 365             
His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro
    370                 375                 380                 
Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr
385                 390                 395                 400 
Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn
                405                 410                 415     
Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His
            420                 425                 430         
Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile
        435                 440                 445             
Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile
    450                 455                 460                 
Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu
465                 470                 475                 480 
Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp
                485                 490                 495     
Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met
            500                 505                 510         
Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln
        515                 520                 525             
Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly
    530                 535                 540                 
Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met
545                 550                 555                 560 
Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn
                565                 570                 575     
Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val
            580                 585                 590         
Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu
        595                 600                 605             
Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser
    610                 615                 620                 
Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr
625                 630                 635                 640 
Thr Ser Pro Arg Leu Pro Val Phe
                645             


<210> 6131
<211> 1447
<212> PRT
<213> Homo sapiens

<400> 6131
Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys Ile Thr Tyr Pro
 1               5                  10                  15      
Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys Glu Glu Met Val
            20                  25                  30          
Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp
        35                  40                  45              
Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala Leu His Leu Ala
    50                  55                  60                  
Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val Arg Leu Leu Val
65                  70                  75                  80  
Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro
                85                  90                  95      
Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met Phe Ile Thr Arg
            100                 105                 110         
Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr
        115                 120                 125             
Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser Tyr Asn Ile Cys
    130                 135                 140                 
Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln Leu Tyr Arg Thr
145                 150                 155                 160 
Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys Val His Met His
                165                 170                 175     
Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly Asp Thr Val Ser
            180                 185                 190         
Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val Pro Ala His Lys
        195                 200                 205             
Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala Leu Leu Lys Arg
    210                 215                 220                 
Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe Phe Asn Gln Val
225                 230                 235                 240 
Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser Glu His Val Phe
                245                 250                 255     
Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His Leu Leu Leu Ser
            260                 265                 270         
Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Asn Glu Glu
        275                 280                 285             
Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe Gly Ala Lys Asp
    290                 295                 300                 
Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln Cys Tyr Leu Gly
305                 310                 315                 320 
Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu Cys Val Lys Phe
                325                 330                 335     
Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr
            340                 345                 350         
Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His
        355                 360                 365             
Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys Asp Ile Leu Leu
    370                 375                 380                 
Val Asn Asp His Leu Leu Asn Phe Val Arg Glu Arg Thr Leu Asp Lys
385                 390                 395                 400 
Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Ile Tyr
                405                 410                 415     
Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp Ala Ala Lys Gln
            420                 425                 430         
Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser
        435                 440                 445             
Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala Gln Tyr Met Val
    450                 455                 460                 
Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys Leu Tyr Tyr Leu
465                 470                 475                 480 
Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu Asn Glu Met Trp
                485                 490                 495     
Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp Leu Leu Asp Leu
            500                 505                 510         
Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala Ile Phe Ser Lys
        515                 520                 525             
Val Met Val Ile Thr Arg Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp
    530                 535                 540                 
Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg
545                 550                 555                 560 
Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala
                565                 570                 575     
Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln
            580                 585                 590         
Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile
        595                 600                 605             
Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln
    610                 615                 620                 
Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val
625                 630                 635                 640 
Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu
                645                 650                 655     
Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser
            660                 665                 670         
Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala
        675                 680                 685             
Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro
    690                 695                 700                 
His Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys
705                 710                 715                 720 
Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile
                725                 730                 735     
Phe Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe Glu Pro Leu His
            740                 745                 750         
Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val
        755                 760                 765             
Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro
    770                 775                 780                 
Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn
785                 790                 795                 800 
Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu
                805                 810                 815     
Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met
            820                 825                 830         
Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr
        835                 840                 845             
Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu
    850                 855                 860                 
Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu
865                 870                 875                 880 
Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His
                885                 890                 895     
Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn
            900                 905                 910         
Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys
        915                 920                 925             
Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala
    930                 935                 940                 
Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln
945                 950                 955                 960 
Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His
                965                 970                 975     
Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val
            980                 985                 990         
Pro Tyr Thr Ile His Leu Leu Ala His Asp Pro Asp Tyr Val Lys Val
        995                 1000                1005            
Gln Asp Ile Glu Gln Leu Lys Asp Val Lys Glu Cys Leu Trp Phe Val
    1010                1015                1020                
Leu Glu Ile Leu Met Ala Lys Asn Glu Asn Asn Ser His Ala Phe Ile
1025                1030                1035                1040
Arg Lys Met Val Glu Asn Ile Lys Gln Thr Lys Asp Ala Gln Gly Pro
                1045                1050                1055    
Asp Asp Ala Lys Met Asn Glu Lys Leu Tyr Thr Val Cys Asp Val Ala
            1060                1065                1070        
Met Asn Ile Ile Met Ser Lys Ser Thr Thr Tyr Ser Leu Glu Ser Pro
        1075                1080                1085            
Lys Asp Pro Val Leu Pro Ala Arg Phe Phe Thr Gln Pro Asp Lys Asn
    1090                1095                1100                
Phe Ser Asn Thr Lys Asn Tyr Leu Pro Pro Glu Met Lys Ser Phe Phe
1105                1110                1115                1120
Thr Pro Gly Lys Pro Lys Thr Thr Asn Val Leu Gly Ala Val Asn Lys
                1125                1130                1135    
Pro Leu Ser Ser Ala Gly Lys Gln Ser Gln Thr Lys Ser Ser Arg Met
            1140                1145                1150        
Glu Thr Val Ser Asn Ala Ser Ser Ser Ser Asn Pro Ser Ser Pro Gly
        1155                1160                1165            
Arg Ile Lys Gly Arg Leu Asp Ser Ser Glu Met Asp His Ser Glu Asn
    1170                1175                1180                
Glu Asp Tyr Thr Met Ser Ser Pro Leu Pro Gly Lys Lys Ser Asp Lys
1185                1190                1195                1200
Arg Asp Asp Ser Asp Leu Val Arg Ser Glu Leu Glu Lys Pro Arg Gly
                1205                1210                1215    
Arg Lys Lys Thr Pro Val Thr Glu Gln Glu Glu Lys Leu Gly Met Asp
            1220                1225                1230        
Asp Leu Thr Lys Leu Val Gln Glu Gln Lys Pro Lys Gly Ser Gln Arg
        1235                1240                1245            
Ser Arg Lys Arg Gly His Thr Ala Ser Glu Ser Asp Glu Gln Gln Trp
    1250                1255                1260                
Pro Glu Glu Lys Arg Leu Lys Glu Asp Ile Leu Glu Asn Glu Asp Glu
1265                1270                1275                1280
Gln Asn Ser Pro Pro Lys Lys Gly Lys Arg Gly Arg Pro Pro Lys Pro
                1285                1290                1295    
Leu Gly Gly Gly Thr Pro Lys Glu Glu Pro Thr Met Lys Thr Ser Lys
            1300                1305                1310        
Lys Gly Ser Lys Lys Lys Ser Gly Pro Pro Ala Pro Glu Glu Glu Glu
        1315                1320                1325            
Glu Glu Glu Arg Gln Ser Gly Asn Thr Glu Gln Lys Ser Lys Ser Lys
    1330                1335                1340                
Gln His Arg Val Ser Arg Arg Ala Gln Gln Arg Ala Glu Ser Pro Glu
1345                1350                1355                1360
Ser Ser Ala Ile Glu Ser Thr Gln Ser Thr Pro Gln Lys Gly Arg Gly
                1365                1370                1375    
Arg Pro Ser Lys Thr Pro Ser Pro Ser Gln Pro Lys Lys Asn Val Arg
            1380                1385                1390        
Val Gly Arg Ser Lys Gln Ala Ala Thr Lys Glu Asn Asp Ser Ser Glu
        1395                1400                1405            
Glu Val Asp Val Phe Gln Gly Ser Ser Pro Val Asp Asp Ile Pro Gln
    1410                1415                1420                
Glu Glu Thr Glu Glu Glu Glu Val Ser Thr Val Asn Val Arg Arg Arg
1425                1430                1435                1440
Ser Ala Lys Arg Glu Arg Arg
                1445        


<210> 6132
<211> 1483
<212> PRT
<213> Homo sapiens

<400> 6132
Gly Gly Gly Arg Arg Arg Leu Asp Ala Ala Ala Ala Ala Asp Pro Gly
 1               5                  10                  15      
Glu Pro Arg Ser Glu Arg Ser Ser Glu Ser Ala Thr Arg Arg Gly Arg
            20                  25                  30          
Asn Ile Ser Val Met Ala His Ser Lys Thr Arg Thr Asn Asp Gly Lys
        35                  40                  45              
Ile Thr Tyr Pro Pro Gly Val Lys Glu Ile Ser Asp Lys Ile Ser Lys
    50                  55                  60                  
Glu Glu Met Val Arg Arg Leu Lys Met Val Val Lys Thr Phe Met Asp
65                  70                  75                  80  
Met Asp Gln Asp Ser Glu Glu Glu Lys Glu Leu Tyr Leu Asn Leu Ala
                85                  90                  95      
Leu His Leu Ala Ser Asp Phe Phe Leu Lys His Pro Asp Lys Asp Val
            100                 105                 110         
Arg Leu Leu Val Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala
        115                 120                 125             
Pro Glu Ala Pro Tyr Thr Ser Pro Asp Lys Leu Lys Asp Ile Phe Met
    130                 135                 140                 
Phe Ile Thr Arg Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln
145                 150                 155                 160 
Phe Asn Arg Tyr Phe Tyr Leu Leu Glu Asn Ile Ala Trp Val Lys Ser
                165                 170                 175     
Tyr Asn Ile Cys Phe Glu Leu Glu Asp Ser Asn Glu Ile Phe Thr Gln
            180                 185                 190         
Leu Tyr Arg Thr Leu Phe Ser Val Ile Asn Asn Gly His Asn Gln Lys
        195                 200                 205             
Val His Met His Met Val Asp Leu Met Ser Ser Ile Ile Cys Glu Gly
    210                 215                 220                 
Asp Thr Val Ser Gln Glu Leu Leu Asp Thr Val Leu Val Asn Leu Val
225                 230                 235                 240 
Pro Ala His Lys Asn Leu Asn Lys Gln Ala Tyr Asp Leu Ala Lys Ala
                245                 250                 255     
Leu Leu Lys Arg Thr Ala Gln Ala Ile Glu Pro Tyr Ile Thr Asn Phe
            260                 265                 270         
Phe Asn Gln Val Leu Met Leu Gly Lys Thr Ser Ile Ser Asp Leu Ser
        275                 280                 285             
Glu His Val Phe Asp Leu Ile Leu Glu Leu Tyr Asn Ile Asp Ser His
    290                 295                 300                 
Leu Leu Leu Ser Val Leu Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn
305                 310                 315                 320 
Asp Asn Glu Glu Arg Leu Gln Val Val Lys Leu Leu Ala Lys Met Phe
                325                 330                 335     
Gly Ala Lys Asp Ser Glu Leu Ala Ser Gln Asn Lys Pro Leu Trp Gln
            340                 345                 350         
Cys Tyr Leu Gly Arg Phe Asn Asp Ile His Val Pro Ile Arg Leu Glu
        355                 360                 365             
Cys Val Lys Phe Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala
    370                 375                 380                 
Lys Asp Leu Thr Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu
385                 390                 395                 400 
Ala Ile Arg His Asp Val Ile Val Ser Ile Val Thr Ala Ala Lys Lys
                405                 410                 415     
Asp Ile Leu Leu Val Asn Asp His Leu Leu Asn Phe Val Arg Glu Arg
            420                 425                 430         
Thr Leu Asp Lys Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu
        435                 440                 445             
Ala Gln Ile Tyr Lys Lys Tyr Ala Leu Gln Ser Ala Ala Gly Lys Asp
    450                 455                 460                 
Ala Ala Lys Gln Ile Ala Trp Ile Lys Asp Lys Leu Leu His Ile Tyr
465                 470                 475                 480 
Tyr Gln Asn Ser Ile Asp Asp Arg Leu Leu Val Glu Arg Ile Phe Ala
                485                 490                 495     
Gln Tyr Met Val Pro His Asn Leu Glu Thr Thr Glu Arg Met Lys Cys
            500                 505                 510         
Leu Tyr Tyr Leu Tyr Ala Thr Leu Asp Leu Asn Ala Val Lys Ala Leu
        515                 520                 525             
Asn Glu Met Trp Lys Cys Gln Asn Leu Leu Arg His Gln Val Lys Asp
    530                 535                 540                 
Leu Leu Asp Leu Ile Lys Gln Pro Lys Thr Asp Ala Ser Val Lys Ala
545                 550                 555                 560 
Ile Phe Ser Lys Val Met Val Ile Thr Arg Asn Leu Pro Asp Pro Gly
                565                 570                 575     
Lys Ala Gln Asp Phe Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp
            580                 585                 590         
Glu Lys Ile Arg Lys Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser
        595                 600                 605             
Cys Lys Gln Ala Glu Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly
    610                 615                 620                 
Asn Pro Lys Gln Pro Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu
625                 630                 635                 640 
Leu Glu Arg Ile Ala Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala
                645                 650                 655     
Leu Ile Lys Gln Val Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu
            660                 665                 670         
Asp Glu Gly Val Pro Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu
        675                 680                 685             
Leu Lys Val Leu Ser Phe Thr His Pro Ile Ser Phe His Ser Ala Glu
    690                 695                 700                 
Thr Phe Glu Ser Leu Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val
705                 710                 715                 720 
Ala Glu Ala Ala Leu Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu
                725                 730                 735     
Glu Asp Phe Pro His Ile Arg Ser Ala Leu Leu Pro Val Leu His His
            740                 745                 750         
Lys Ser Lys Lys Gly Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys
        755                 760                 765             
Ile His Ala Ile Phe Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe
    770                 775                 780                 
Glu Pro Leu His Lys Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile
785                 790                 795                 800 
Thr Pro Leu Val Thr Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln
                805                 810                 815     
Phe Ala Ala Pro Leu Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp
            820                 825                 830         
Leu Leu Met Asn Asp Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp
        835                 840                 845             
Val Pro Asp Glu Glu Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala
    850                 855                 860                 
Ile Lys Met Met Val Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser
865                 870                 875                 880 
Lys Ser Gly Thr Ser Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser
                885                 890                 895     
Asp Gly Asp Leu Thr Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser
            900                 905                 910         
Arg Leu Arg Leu Ala Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu
        915                 920                 925             
Pro Cys Tyr His Glu Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala
    930                 935                 940                 
Leu Ala Ile Asn Asp Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln
945                 950                 955                 960 
Lys Leu His Lys Gly Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met
                965                 970                 975     
Ala Ile Cys Ala Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala
            980                 985                 990         
His Ala Arg Gln Cys Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr
        995                 1000                1005            
Leu Lys Gln His Ala Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro
    1010                1015                1020                
Glu Tyr Val Val Pro Tyr Thr Ile His Leu Leu Ala His Asp Pro Asp
1025                1030                1035                1040
Tyr Val Lys Val Gln Asp Ile Glu Gln Leu Lys Asp Val Lys Glu Cys
                1045                1050                1055    
Leu Trp Phe Val Leu Glu Ile Leu Met Ala Lys Asn Glu Asn Asn Ser
            1060                1065                1070        
His Ala Phe Ile Arg Lys Met Val Glu Asn Ile Lys Gln Thr Lys Asp
        1075                1080                1085            
Ala Gln Gly Pro Asp Asp Ala Lys Met Asn Glu Lys Leu Tyr Thr Val
    1090                1095                1100                
Cys Asp Val Ala Met Asn Ile Ile Met Ser Lys Ser Thr Thr Tyr Ser
1105                1110                1115                1120
Leu Glu Ser Pro Lys Asp Pro Val Leu Pro Ala Arg Phe Phe Thr Gln
                1125                1130                1135    
Pro Asp Lys Asn Phe Ser Asn Thr Lys Asn Tyr Leu Pro Pro Glu Met
            1140                1145                1150        
Lys Ser Phe Phe Thr Pro Gly Lys Pro Lys Thr Thr Asn Val Leu Gly
        1155                1160                1165            
Ala Val Asn Lys Pro Leu Ser Ser Ala Gly Lys Gln Ser Gln Thr Lys
    1170                1175                1180                
Ser Ser Arg Met Glu Thr Val Ser Asn Ala Ser Ser Ser Ser Asn Pro
1185                1190                1195                1200
Ser Ser Pro Gly Arg Ile Lys Gly Arg Leu Asp Ser Ser Glu Met Asp
                1205                1210                1215    
His Ser Glu Asn Glu Asp Tyr Thr Met Ser Ser Pro Leu Pro Gly Lys
            1220                1225                1230        
Lys Ser Asp Lys Arg Asp Asp Ser Asp Leu Val Arg Ser Glu Leu Glu
        1235                1240                1245            
Lys Pro Arg Gly Arg Lys Lys Thr Pro Val Thr Glu Gln Glu Glu Lys
    1250                1255                1260                
Leu Gly Met Asp Asp Leu Thr Lys Leu Val Gln Glu Gln Lys Pro Lys
1265                1270                1275                1280
Gly Ser Gln Arg Ser Arg Lys Arg Gly His Thr Ala Ser Glu Ser Asp
                1285                1290                1295    
Glu Gln Gln Trp Pro Glu Glu Lys Arg Leu Lys Glu Asp Ile Leu Glu
            1300                1305                1310        
Asn Glu Asp Glu Gln Asn Ser Pro Pro Lys Lys Gly Lys Arg Gly Arg
        1315                1320                1325            
Pro Pro Lys Pro Leu Gly Gly Gly Thr Pro Lys Glu Glu Pro Thr Met
    1330                1335                1340                
Lys Thr Ser Lys Lys Gly Ser Lys Lys Lys Ser Gly Pro Pro Ala Pro
1345                1350                1355                1360
Glu Glu Glu Glu Glu Glu Glu Arg Gln Ser Gly Asn Thr Glu Gln Lys
                1365                1370                1375    
Ser Lys Ser Lys Gln His Arg Val Ser Arg Arg Ala Gln Gln Arg Ala
            1380                1385                1390        
Glu Ser Pro Glu Ser Ser Ala Ile Glu Ser Thr Gln Ser Thr Pro Gln
        1395                1400                1405            
Lys Gly Arg Gly Arg Pro Ser Lys Thr Pro Ser Pro Ser Gln Pro Lys
    1410                1415                1420                
Lys Asn Val Arg Val Gly Arg Ser Lys Gln Ala Ala Thr Lys Glu Asn
1425                1430                1435                1440
Asp Ser Ser Glu Glu Val Asp Val Phe Gln Gly Ser Ser Pro Val Asp
                1445                1450                1455    
Asp Ile Pro Gln Glu Glu Thr Glu Glu Glu Glu Val Ser Thr Val Asn
            1460                1465                1470        
Val Arg Arg Arg Ser Ala Lys Arg Glu Arg Arg
        1475                1480            


<210> 6133
<211> 179
<212> PRT
<213> Homo sapiens

<400> 6133
Met Leu Gly Ala Gly Pro Ala Gly Val Phe Val Lys Val Ser Leu Met
 1               5                  10                  15      
Asn His Asn Lys Phe Val Lys Cys Lys Lys Thr Ser Ala Val Leu Gly
            20                  25                  30          
Ser Ile Asn Pro Val Tyr Asn Glu Thr Phe Ser Phe Lys Ala Asp Ala
        35                  40                  45              
Thr Lys Leu Asp Thr Ala Ser Leu Ser Leu Thr Ala Val Gln Asn Met
    50                  55                  60                  
Glu Gly Asp Thr Pro Arg Phe Arg Phe Gly Ser Arg Pro Ser Ser Gln
65                  70                  75                  80  
Leu His Val Thr Ala Thr Ala Thr Arg Met Asp Val Ser Ser Asn Ser
                85                  90                  95      
Ser Pro Ser Cys Gln Ala Ser Pro Ser Gln Glu Asp Val Ser Ala Asp
            100                 105                 110         
Met Gln Glu Arg Arg Gly Asp Lys Glu Val Leu Ala Arg Pro Asp Leu
        115                 120                 125             
Asp Gln Asn Leu Arg Cys Ser Glu Glu Arg Ser Cys Leu Val Met Thr
    130                 135                 140                 
Gln Leu Tyr Leu Leu Asn Gly Pro Ala Gly Ala Gly Tyr Tyr Ser Gly
145                 150                 155                 160 
Thr Val Pro Val Ser Ser Asp Ile Arg Ile Asp Ala Ser His Pro His
                165                 170                 175     
Ile Pro Lys
            


<210> 6134
<211> 414
<212> PRT
<213> Homo sapiens

<400> 6134
Asp Phe Val Pro Leu Tyr Gln Asp Phe Glu Asn Phe Tyr Thr Arg Asn
 1               5                  10                  15      
Leu Tyr Met Arg Ile Arg Asp Asn Trp Asn Arg Pro Ile Cys Ser Ala
            20                  25                  30          
Pro Gly Pro Leu Phe Asp Leu Met Glu Arg Val Ser Asp Asp Tyr Asn
        35                  40                  45              
Trp Thr Phe Arg Phe Thr Gly Arg Val Ile Lys Asp Val Ile Asn Met
    50                  55                  60                  
Gly Ser Tyr Asn Phe Leu Gly Leu Ala Ala Lys Tyr Asp Glu Ser Met
65                  70                  75                  80  
Arg Thr Ile Lys Asp Val Leu Glu Val Tyr Gly Thr Gly Val Ala Ser
                85                  90                  95      
Thr Arg His Glu Met Gly Thr Leu Asp Lys His Lys Glu Leu Glu Asp
            100                 105                 110         
Leu Val Ala Lys Phe Leu Asn Val Glu Ala Ala Met Val Phe Gly Met
        115                 120                 125             
Gly Phe Ala Thr Asn Ser Met Asn Ile Pro Ala Leu Val Gly Lys Gly
    130                 135                 140                 
Cys Leu Ile Leu Ser Asp Glu Leu Asn His Thr Ser Leu Val Leu Gly
145                 150                 155                 160 
Ala Arg Leu Ser Gly Ala Thr Ile Arg Ile Phe Lys His Asn Asn Thr
                165                 170                 175     
Gln Ser Leu Glu Lys Leu Leu Arg Asp Ala Val Ile Tyr Gly Gln Pro
            180                 185                 190         
Arg Thr Arg Arg Ala Trp Lys Lys Ile Leu Ile Leu Val Glu Gly Val
        195                 200                 205             
Tyr Ser Met Glu Gly Ser Ile Val His Leu Pro Gln Ile Ile Ala Leu
    210                 215                 220                 
Lys Lys Lys Tyr Lys Ala Tyr Leu Tyr Ile Asp Glu Ala His Ser Ile
225                 230                 235                 240 
Gly Ala Val Gly Pro Thr Gly Arg Gly Val Thr Glu Phe Phe Gly Leu
                245                 250                 255     
Asp Pro His Glu Val Asp Val Leu Met Gly Thr Phe Thr Lys Ser Phe
            260                 265                 270         
Gly Ala Ser Gly Gly Tyr Ile Ala Gly Arg Lys Asp Leu Val Asp Tyr
        275                 280                 285             
Leu Arg Val His Ser His Ser Ala Val Tyr Ala Ser Ser Met Ser Pro
    290                 295                 300                 
Pro Ile Ala Glu Gln Ile Ile Arg Ser Leu Lys Leu Ile Met Gly Leu
305                 310                 315                 320 
Asp Gly Thr Thr Gln Gly Leu Gln Arg Val Gln Gln Leu Ala Lys Asn
                325                 330                 335     
Thr Arg Tyr Phe Arg Gln Arg Leu Gln Glu Met Gly Phe Ile Ile Tyr
            340                 345                 350         
Gly Asn Glu Asn Ala Ser Val Val Pro Leu Leu Leu Tyr Met Pro Gly
        355                 360                 365             
Lys Val Ala Ala Phe Ala Arg His Met Leu Glu Lys Lys Ile Gly Val
    370                 375                 380                 
Val Val Val Gly Phe Pro Ala Thr Pro Leu Ala Glu Ala Arg Ala Arg
385                 390                 395                 400 
Phe Cys Val Ser Ala Ala His Thr Arg Glu Met Leu Asp Thr
                405                 410                 


<210> 6135
<211> 134
<212> PRT
<213> Homo sapiens

<400> 6135
Met Gly Leu Asp Gly Thr Thr Gln Gly Leu Gln Arg Val Gln Gln Leu
 1               5                  10                  15      
Ala Lys Asn Thr Arg Tyr Phe Arg Gln Arg Leu Gln Glu Met Gly Phe
            20                  25                  30          
Ile Ile Tyr Gly Asn Glu Asn Ala Ser Val Val Pro Leu Leu Leu Tyr
        35                  40                  45              
Met Pro Gly Lys Val Ala Ala Phe Ala Arg His Met Leu Glu Lys Lys
    50                  55                  60                  
Ile Gly Val Val Val Val Gly Phe Pro Ala Thr Pro Leu Ala Glu Ala
65                  70                  75                  80  
Arg Ala Arg Phe Cys Val Ser Ala Ala His Thr Arg Glu Met Leu Asp
                85                  90                  95      
Thr Val Leu Glu Ala Leu Asp Glu Met Gly Asp Leu Leu Gln Leu Lys
            100                 105                 110         
Tyr Ser Arg His Lys Lys Ser Ala Arg Pro Glu Leu Tyr Asp Glu Thr
        115                 120                 125             
Ser Phe Glu Leu Glu Asp
    130                 


<210> 6136
<211> 2139
<212> PRT
<213> Homo sapiens

<400> 6136
Met Ile Leu Asp Gln Ala Phe Lys Tyr Ile Thr Glu Leu Lys Arg Gln
 1               5                  10                  15      
Asn Asp Glu Leu Leu Leu Asn Gly Gly Asn Asn Glu Gln Ala Glu Glu
            20                  25                  30          
Ile Lys Lys Leu Arg Lys Gln Leu Glu Glu Ile Gln Lys Glu Asn Gly
        35                  40                  45              
Arg Tyr Ile Glu Leu Leu Lys Ala Asn Asp Ile Cys Leu Tyr Asp Asp
    50                  55                  60                  
Pro Thr Ile His Trp Lys Gly Asn Leu Lys Asn Ser Lys Val Ser Val
65                  70                  75                  80  
Val Ile Pro Ser Asp Gln Val Gln Lys Lys Ile Ile Val Tyr Ser Asn
                85                  90                  95      
Gly Asn Gln Pro Gly Gly Asn Ser Gln Gly Thr Ala Val Gln Gly Ile
            100                 105                 110         
Thr Phe Asn Val Ser His Asn Leu Gln Lys Gln Thr Ala Asn Val Val
        115                 120                 125             
Pro Val Gln Arg Thr Cys Asn Leu Val Thr Pro Val Ser Ile Ser Gly
    130                 135                 140                 
Val Tyr Pro Ser Glu Asn Lys Pro Trp His Gln Thr Thr Val Pro Ala
145                 150                 155                 160 
Leu Ala Thr Asn Gln Pro Val Pro Leu Cys Leu Pro Ala Ala Ile Ser
                165                 170                 175     
Ala Gln Ser Ile Leu Glu Leu Pro Thr Ser Glu Ser Glu Ser Asn Val
            180                 185                 190         
Leu Gly Ala Thr Ser Gly Ser Leu Ile Ala Val Ser Ile Glu Ser Glu
        195                 200                 205             
Pro His Gln His His Ser Leu His Thr Cys Leu Asn Asp Gln Asn Ser
    210                 215                 220                 
Ser Glu Asn Lys Asn Gly Gln Glu Asn Pro Lys Val Leu Lys Lys Met
225                 230                 235                 240 
Thr Pro Cys Val Thr Asn Ile Pro His Ser Ser Ser Ala Thr Ala Thr
                245                 250                 255     
Lys Val His His Gly Asn Lys Ser Cys Leu Ser Ile Gln Asp Phe Arg
            260                 265                 270         
Gly Asp Phe Gln Asn Thr Phe Val Val Ser Val Thr Thr Thr Val Cys
        275                 280                 285             
Ser Gln Pro Pro Arg Thr Ala Gly Asp Ser Ser Pro Met Ser Ile Ser
    290                 295                 300                 
Lys Ser Ala Asp Leu Thr Ser Thr Ala Thr Val Val Ala Ser Ser Ala
305                 310                 315                 320 
Pro Gly Val Gly Lys Ala Thr Ile Pro Ile Ser Thr Leu Ser Gly Asn
                325                 330                 335     
Pro Leu Asp Asn Gly Trp Thr Leu Ser Cys Ser Leu Pro Ser Ser Ser
            340                 345                 350         
Val Ser Thr Ser Asp Leu Lys Asn Ile Asn Ser Leu Thr Arg Ile Ser
        355                 360                 365             
Ser Ala Gly Asn Thr Gln Thr Thr Trp Thr Thr Leu Gln Leu Ala Gly
    370                 375                 380                 
Asn Thr Ile Gln Pro Leu Ser Gln Thr Pro Ser Ser Ala Val Thr Pro
385                 390                 395                 400 
Val Leu Asn Glu Ser Gly Thr Ser Pro Thr Thr Ser Asn His Ser Arg
                405                 410                 415     
Tyr Val Ala Thr Asp Ile Asn Leu Asn Asn Ser Phe Pro Ala Asp Gly
            420                 425                 430         
Gln Pro Val Glu Gln Val Val Val Thr Leu Pro Ser Cys Pro Ser Leu
        435                 440                 445             
Pro Met Gln Pro Leu Ile Ala Gln Pro Gln Val Lys Ser Gln Pro Pro
    450                 455                 460                 
Lys Asn Ile Leu Pro Leu Asn Ser Ala Met Gln Val Ile Gln Met Ala
465                 470                 475                 480 
Gln Pro Val Gly Ser Ala Val Asn Ser Ala Pro Thr Asn Gln Asn Val
                485                 490                 495     
Ile Ile Leu Gln Pro Pro Ser Thr Thr Pro Cys Pro Thr Val Met Arg
            500                 505                 510         
Ala Glu Val Ser Asn Gln Thr Val Gly Gln Gln Ile Val Ile Ile Gln
        515                 520                 525             
Ala Ala Asn Gln Asn Pro Leu Pro Leu Leu Pro Ala Pro Pro Pro Gly
    530                 535                 540                 
Ser Val Arg Leu Pro Ile Asn Gly Ala Asn Thr Val Ile Gly Ser Asn
545                 550                 555                 560 
Asn Ser Val Gln Asn Val Pro Thr Pro Gln Thr Phe Gly Gly Lys His
                565                 570                 575     
Leu Val His Ile Leu Pro Arg Pro Ser Ser Leu Ser Ala Ser Asn Ser
            580                 585                 590         
Thr Gln Thr Phe Ser Val Thr Met Ser Asn Gln Gln Pro Gln Thr Ile
        595                 600                 605             
Ser Leu Asn Gly Gln Leu Phe Ala Leu Gln Pro Val Met Ser Ser Ser
    610                 615                 620                 
Gly Thr Thr Asn Gln Thr Pro Met Gln Ile Ile Gln Pro Thr Thr Ser
625                 630                 635                 640 
Glu Asp Pro Asn Thr Asn Val Ala Leu Asn Thr Phe Gly Ala Leu Ala
                645                 650                 655     
Ser Leu Asn Gln Ser Ile Ser Gln Met Ala Gly Gln Ser Cys Val Gln
            660                 665                 670         
Leu Ser Ile Ser Gln Pro Ala Asn Ser Gln Thr Ala Ala Asn Ser Gln
        675                 680                 685             
Thr Thr Thr Ala Asn Cys Val Ser Leu Thr Thr Thr Ala Ala Pro Pro
    690                 695                 700                 
Val Thr Thr Asp Ser Ser Ala Thr Leu Ala Ser Thr Tyr Asn Leu Val
705                 710                 715                 720 
Ser Thr Ser Ser Met Asn Thr Val Ala Cys Leu Pro Asn Met Lys Ser
                725                 730                 735     
Lys Arg Leu Asn Lys Lys Pro Gly Gly Arg Lys His Leu Ala Ala Asn
            740                 745                 750         
Lys Ser Ala Cys Pro Leu Asn Ser Val Arg Asp Val Ser Lys Leu Asp
        755                 760                 765             
Cys Pro Asn Thr Glu Gly Ser Ala Glu Pro Pro Cys Asn Asp Gly Leu
    770                 775                 780                 
Leu Glu Ser Phe Pro Ala Val Leu Pro Ser Val Ser Val Ser Gln Ala
785                 790                 795                 800 
Asn Ser Val Ser Val Ser Ala Ser His Ser Leu Gly Val Leu Ser Ser
                805                 810                 815     
Glu Ser Leu Ile Pro Glu Ser Val Ser Lys Ser Lys Ser Ala Glu Lys
            820                 825                 830         
Ser Ser Pro Pro Ser Gln Glu Ser Val Thr Ser Glu His Phe Ala Met
        835                 840                 845             
Ala Ala Ala Lys Ser Lys Asp Ser Thr Pro Asn Leu Gln Gln Glu Thr
    850                 855                 860                 
Ser Gln Asp Lys Pro Pro Ser Ser Leu Ala Leu Ser Asp Ala Ala Lys
865                 870                 875                 880 
Pro Cys Ala Ser Ala Asn Val Leu Ile Pro Ser Pro Ser Asp Pro His
                885                 890                 895     
Ile Leu Val Ser Gln Val Pro Gly Leu Ser Ser Thr Thr Ser Thr Thr
            900                 905                 910         
Ser Thr Asp Cys Val Ser Glu Val Glu Ile Ile Ala Glu Pro Cys Arg
        915                 920                 925             
Val Glu Gln Asp Ser Ser Asp Thr Met Gln Thr Thr Gly Leu Leu Lys
    930                 935                 940                 
Gly Gln Gly Leu Thr Thr Leu Leu Ser Asp Leu Ala Lys Lys Lys Asn
945                 950                 955                 960 
Pro Gln Lys Ser Ser Leu Ser Asp Gln Met Asp His Pro Asp Phe Ser
                965                 970                 975     
Ser Glu Asn Pro Lys Ile Val Asp Ser Ser Val Asn Leu His Pro Lys
            980                 985                 990         
Gln Glu Leu Leu Leu Met Asn Asn Asp Asp Arg Asp Pro Pro Gln His
        995                 1000                1005            
His Ser Cys Leu Pro Asp Gln Glu Val Ile Asn Gly Ser Leu Ile Asn
    1010                1015                1020                
Gly Arg Gln Ala Asp Ser Pro Met Ser Thr Ser Ser Gly Ser Ser Arg
1025                1030                1035                1040
Ser Phe Ser Val Ala Ser Met Leu Pro Glu Thr Thr Arg Glu Asp Val
                1045                1050                1055    
Thr Ser Asn Ala Thr Thr Asn Thr Cys Asp Ser Cys Thr Phe Val Glu
            1060                1065                1070        
Gln Thr Asp Ile Val Ala Leu Ala Ala Arg Ala Ile Phe Asp Gln Glu
        1075                1080                1085            
Asn Leu Glu Lys Gly Arg Val Gly Leu Gln Ala Asp Ile Arg Glu Val
    1090                1095                1100                
Ala Ser Lys Pro Ser Glu Ala Ser Leu Leu Glu Gly Asp Pro Pro Phe
1105                1110                1115                1120
Lys Ser Gln Ile Pro Lys Glu Ser Gly Thr Gly Gln Ala Glu Ala Thr
                1125                1130                1135    
Pro Asn Glu Phe Asn Ser Gln Gly Ser Ile Glu Ala Thr Met Glu Arg
            1140                1145                1150        
Pro Leu Glu Lys Pro Ser Cys Ser Leu Gly Ile Lys Thr Ser Asn Ala
        1155                1160                1165            
Ser Leu Gln Asp Ser Thr Ser Gln Pro Pro Ser Ile Thr Ser Leu Ser
    1170                1175                1180                
Val Asn Asn Leu Ile His Gln Ser Ser Ile Ser His Pro Leu Ala Ser
1185                1190                1195                1200
Cys Ala Gly Leu Ser Pro Thr Ser Glu Gln Thr Thr Val Pro Ala Thr
                1205                1210                1215    
Val Asn Leu Thr Val Ser Ser Ser Ser Tyr Gly Ser Gln Pro Pro Gly
            1220                1225                1230        
Pro Ser Leu Met Thr Glu Tyr Ser Gln Glu Gln Leu Asn Thr Met Thr
        1235                1240                1245            
Ser Thr Ile Pro Asn Ser Gln Ile Gln Glu Pro Leu Leu Lys Pro Ser
    1250                1255                1260                
His Glu Ser Arg Lys Asp Ser Ala Lys Arg Ala Val Gln Asp Asp Leu
1265                1270                1275                1280
Leu Leu Ser Ser Ala Lys Arg Gln Lys His Cys Gln Pro Ala Pro Leu
                1285                1290                1295    
Arg Leu Glu Ser Met Ser Leu Met Ser Arg Thr Pro Asp Thr Ile Ser
            1300                1305                1310        
Asp Gln Thr Gln Met Met Val Ser Gln Ile Pro Pro Asn Ser Ser Asn
        1315                1320                1325            
Ser Val Val Pro Val Ser Asn Pro Ala His Gly Asp Gly Leu Thr Arg
    1330                1335                1340                
Leu Phe Pro Pro Ser Asn Asn Phe Val Thr Pro Ala Leu Arg Gln Thr
1345                1350                1355                1360
Glu Val Gln Cys Gly Ser Gln Pro Ser Val Ala Glu Gln Gln Gln Thr
                1365                1370                1375    
Gln Ala Ser Gln His Leu Gln Ala Leu Gln Gln His Val Pro Ala Gln
            1380                1385                1390        
Glu Ser Ser Val His Ser Gln Pro His Asn Val His Gln Gln Arg Thr
        1395                1400                1405            
Leu Gln Gln Glu Val Gln Met Gln Lys Lys Arg Asn Leu Val Gln Gly
    1410                1415                1420                
Thr Gln Thr Ser Gln Leu Ser Leu Gln Pro Lys His His Gly Thr Asp
1425                1430                1435                1440
Gln Ser Arg Ser Lys Thr Gly Gln Pro His Pro His His Gln Gln Met
                1445                1450                1455    
Gln Gln Gln Met Gln Gln His Phe Gly Ser Ser Gln Thr Glu Lys Ser
            1460                1465                1470        
Cys Glu Asn Pro Ser Thr Ser Arg Asn His His Asn His Pro Gln Asn
        1475                1480                1485            
His Leu Asn Gln Asp Ile Met His Gln Gln Gln Asp Val Gly Ser Arg
    1490                1495                1500                
Gln Gln Gly Ser Gly Val Ser Ser Glu His Val Ser Gly His Asn Pro
1505                1510                1515                1520
Met Gln Arg Leu Leu Thr Ser Arg Gly Leu Glu Gln Gln Met Val Ser
                1525                1530                1535    
Gln Pro Ser Ile Val Thr Arg Ser Ser Asp Met Thr Cys Thr Pro His
            1540                1545                1550        
Arg Pro Glu Arg Asn Arg Val Ser Ser Tyr Ser Ala Glu Ala Leu Ile
        1555                1560                1565            
Gly Lys Thr Ser Ser Asn Ser Glu Gln Arg Met Gly Ile Ser Ile Gln
    1570                1575                1580                
Gly Ser Arg Val Ser Asp Gln Leu Glu Met Arg Ser Tyr Leu Asp Val
1585                1590                1595                1600
Pro Arg Asn Lys Ser Leu Ala Ile His Asn Met Gln Gly Arg Val Asp
                1605                1610                1615    
His Thr Val Ala Ser Asp Ile Arg Leu Ser Asp Cys Gln Thr Phe Lys
            1620                1625                1630        
Pro Ser Gly Ala Ser Gln Gln Pro Gln Ser Asn Phe Glu Val Gln Ser
        1635                1640                1645            
Ser Arg Asn Asn Glu Ile Gly Asn Pro Val Ser Ser Leu Arg Ser Met
    1650                1655                1660                
Gln Ser Gln Ala Phe Arg Ile Ser Gln Asn Thr Gly Pro Pro Pro Ile
1665                1670                1675                1680
Asp Arg Gln Lys Arg Leu Ser Tyr Pro Pro Val Gln Ser Ile Pro Thr
                1685                1690                1695    
Gly Asn Gly Ile Pro Ser Arg Asp Ser Glu Asn Thr Cys His Gln Ser
            1700                1705                1710        
Phe Met Gln Ser Leu Leu Ala Pro His Leu Ser Asp Gln Val Ile Gly
        1715                1720                1725            
Ser Gln Arg Ser Leu Ser Glu His Gln Arg Asn Thr Gln Cys Gly Pro
    1730                1735                1740                
Ser Ser Ala Ile Glu Tyr Asn Cys Pro Pro Thr His Glu Asn Val His
1745                1750                1755                1760
Ile Arg Arg Glu Ser Glu Ser Gln Asn Arg Glu Ser Cys Asp Met Ser
                1765                1770                1775    
Leu Gly Ala Ile Asn Thr Arg Asn Ser Thr Leu Asn Ile Pro Phe Ser
            1780                1785                1790        
Ser Ser Ser Ser Ser Gly Asp Ile Gln Gly Arg Asn Thr Ser Pro Asn
        1795                1800                1805            
Val Ser Val Gln Lys Ser Asn Pro Met Arg Ile Thr Glu Ser His Ala
    1810                1815                1820                
Thr Lys Gly His Met Asn Pro Pro Val Thr Thr Asn Met His Gly Val
1825                1830                1835                1840
Ala Arg Pro Ala Leu Pro His Pro Ser Val Ser His Gly Asn Gly Asp
                1845                1850                1855    
Gln Gly Pro Ala Val Arg Gln Ala Asn Ser Ser Val Pro Gln Arg Ser
            1860                1865                1870        
Arg His Pro Leu Gln Asp Ser Ser Gly Ser Lys Ile Arg Gln Pro Glu
        1875                1880                1885            
Arg Asn Arg Ser Gly Asn Gln Arg Gln Ser Thr Val Phe Asp Pro Ser
    1890                1895                1900                
Leu Pro His Leu Pro Leu Ser Thr Gly Gly Ser Met Ile Leu Gly Arg
1905                1910                1915                1920
Gln Gln Pro Ala Thr Glu Lys Arg Gly Ser Ile Val Arg Phe Met Pro
                1925                1930                1935    
Asp Ser Pro Gln Val Pro Asn Asp Asn Ser Gly Pro Asp Gln His Thr
            1940                1945                1950        
Leu Ser Gln Asn Phe Gly Phe Ser Phe Ile Pro Glu Gly Gly Met Asn
        1955                1960                1965            
Pro Pro Ile Asn Ala Asn Ala Ser Phe Ile Pro Gln Val Thr Gln Pro
    1970                1975                1980                
Ser Ala Thr Arg Thr Pro Ala Leu Ile Pro Val Asp Pro Gln Asn Thr
1985                1990                1995                2000
Leu Pro Ser Phe Tyr Pro Pro Tyr Ser Pro Ala His Pro Thr Leu Ser
                2005                2010                2015    
Asn Asp Ile Ser Ile Pro Tyr Phe Pro Asn Gln Met Phe Ser Asn Pro
            2020                2025                2030        
Ser Thr Glu Lys Val Asn Ser Gly Ser Leu Asn Asn Arg Phe Gly Ser
        2035                2040                2045            
Ile Leu Ser Pro Pro Arg Pro Val Gly Phe Ala Gln Pro Ser Phe Pro
    2050                2055                2060                
Leu Leu Pro Asp Met Pro Pro Met His Met Thr Asn Ser His Leu Ser
2065                2070                2075                2080
Asn Phe Asn Met Thr Ser Leu Phe Pro Glu Ile Ala Thr Val Leu Pro
                2085                2090                2095    
Asp Gly Ser Ala Met Ser Pro Leu Leu Thr Ile Ala Asn Ser Ser Ala
            2100                2105                2110        
Ser Asp Ser Ser Lys Gln Ser Ser Asn Arg Pro Ala His Asn Ile Ser
        2115                2120                2125            
His Ile Leu Gly His Asp Cys Ser Ser Ala Val
    2130                2135                


<210> 6137
<211> 614
<212> PRT
<213> Homo sapiens

<400> 6137
Met Ser Gly Tyr Ser Ser Asp Arg Asp Arg Gly Arg Asp Arg Gly Phe
 1               5                  10                  15      
Gly Ala Pro Arg Phe Gly Gly Ser Arg Ala Gly Pro Leu Ser Gly Lys
            20                  25                  30          
Lys Phe Gly Asn Pro Gly Glu Lys Leu Val Lys Lys Lys Trp Asn Leu
        35                  40                  45              
Asp Glu Leu Pro Lys Phe Glu Lys Asn Phe Tyr Gln Glu His Pro Asp
    50                  55                  60                  
Leu Ala Arg Arg Thr Ala Gln Glu Val Glu Thr Tyr Arg Arg Ser Lys
65                  70                  75                  80  
Glu Ile Thr Val Arg Gly His Asn Cys Pro Lys Pro Val Leu Asn Phe
                85                  90                  95      
Tyr Glu Ala Asn Phe Pro Ala Asn Val Met Asp Val Ile Ala Arg Gln
            100                 105                 110         
Asn Phe Thr Glu Pro Thr Ala Ile Gln Ala Gln Gly Trp Pro Val Ala
        115                 120                 125             
Leu Ser Gly Leu Asp Met Val Gly Val Ala Gln Thr Gly Ser Gly Lys
    130                 135                 140                 
Thr Leu Ser Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro
145                 150                 155                 160 
Phe Leu Glu Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr
                165                 170                 175     
Arg Glu Leu Ala Gln Gln Val Gln Gln Val Ala Ala Glu Tyr Cys Arg
            180                 185                 190         
Ala Cys Arg Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly
        195                 200                 205             
Pro Gln Ile Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr
    210                 215                 220                 
Pro Gly Arg Leu Ile Asp Phe Leu Glu Cys Gly Lys Thr Asn Leu Arg
225                 230                 235                 240 
Arg Thr Thr Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met
                245                 250                 255     
Gly Phe Glu Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp
            260                 265                 270         
Arg Gln Thr Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln
        275                 280                 285             
Leu Ala Glu Asp Phe Leu Lys Asp Tyr Ile His Ile Asn Ile Gly Ala
    290                 295                 300                 
Leu Glu Leu Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys
305                 310                 315                 320 
His Asp Val Glu Lys Asp Glu Lys Leu Ile Arg Leu Met Glu Glu Ile
                325                 330                 335     
Met Ser Glu Lys Glu Asn Lys Thr Ile Val Phe Val Glu Thr Lys Arg
            340                 345                 350         
Arg Cys Asp Glu Leu Thr Arg Lys Met Arg Arg Asp Gly Trp Pro Ala
        355                 360                 365             
Met Gly Ile His Gly Asp Lys Ser Gln Gln Glu Arg Asp Trp Val Leu
    370                 375                 380                 
Asn Glu Phe Lys His Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val
385                 390                 395                 400 
Ala Ser Arg Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr
                405                 410                 415     
Asp Tyr Pro Asn Ser Ser Glu Asp Tyr Ile His Arg Ile Gly Arg Thr
            420                 425                 430         
Ala Arg Ser Thr Lys Thr Gly Thr Ala Tyr Thr Phe Phe Thr Pro Asn
        435                 440                 445             
Asn Ile Lys Gln Val Ser Asp Leu Ile Ser Val Leu Arg Glu Ala Asn
    450                 455                 460                 
Gln Ala Ile Asn Pro Lys Leu Leu Gln Leu Val Glu Asp Arg Gly Ser
465                 470                 475                 480 
Gly Arg Ser Arg Gly Arg Gly Gly Met Lys Asp Asp Arg Arg Asp Arg
                485                 490                 495     
Tyr Ser Ala Gly Lys Arg Gly Gly Phe Asn Thr Phe Arg Asp Arg Glu
            500                 505                 510         
Asn Tyr Asp Arg Gly Tyr Ser Ser Leu Leu Lys Arg Asp Phe Gly Ala
        515                 520                 525             
Lys Thr Gln Asn Gly Val Tyr Ser Ala Ala Asn Tyr Thr Asn Gly Ser
    530                 535                 540                 
Phe Gly Ser Asn Phe Val Ser Ala Gly Ile Gln Thr Ser Phe Arg Thr
545                 550                 555                 560 
Gly Asn Pro Thr Gly Thr Tyr Gln Asn Gly Tyr Asp Ser Thr Gln Gln
                565                 570                 575     
Tyr Gly Ser Asn Val Pro Asn Met His Asn Gly Met Asn Gln Gln Ala
            580                 585                 590         
Tyr Ala Tyr Pro Ala Thr Ala Ala Ala Pro Met Ile Gly Tyr Pro Met
        595                 600                 605             
Pro Thr Gly Tyr Ser Gln
    610                 


<210> 6138
<211> 1518
<212> PRT
<213> Homo sapiens

<400> 6138
Met Ala Thr Lys Leu Asp Phe Asn Lys Met Pro Leu Ser Val Phe Pro
 1               5                  10                  15      
Tyr Tyr Ala Ser Leu Gly Thr Ala Leu Tyr Gly Lys Glu Lys Pro Leu
            20                  25                  30          
Ile Lys Leu Pro Ala Pro Phe Glu Glu Ser Leu Asp Leu Pro Leu Trp
        35                  40                  45              
Lys Phe Leu Gln Lys Lys Asn His Leu Ile Glu Glu Ile Asn Asp Glu
    50                  55                  60                  
Met Arg Arg Cys His Cys Glu Leu Thr Trp Ser Gln Leu Ser Gly Lys
65                  70                  75                  80  
Val Thr Ile Arg Pro Ala Ala Thr Leu Val Asn Glu Gly Arg Pro Arg
                85                  90                  95      
Ile Lys Thr Trp Gln Ala Asp Thr Ser Thr Thr Leu Ser Ser Ile Arg
            100                 105                 110         
Ser Lys Tyr Lys Val Asn Pro Ile Lys Val Asp Pro Thr Met Trp Asp
        115                 120                 125             
Thr Ile Lys Asn Asp Val Lys Asp Asp Arg Ile Leu Ile Glu Phe Asp
    130                 135                 140                 
Thr Leu Lys Glu Met Val Ile Leu Ala Gly Lys Ser Glu Asp Val Gln
145                 150                 155                 160 
Ser Ile Glu Val Gln Val Arg Glu Leu Ile Glu Ser Thr Thr Gln Lys
                165                 170                 175     
Ile Lys Arg Glu Glu Gln Ser Leu Lys Glu Lys Met Ile Ile Ser Pro
            180                 185                 190         
Gly Arg Tyr Phe Leu Leu Cys His Ser Ser Leu Leu Asp His Leu Leu
        195                 200                 205             
Thr Glu Cys Pro Glu Ile Glu Ile Cys Tyr Asp Arg Val Thr Gln His
    210                 215                 220                 
Leu Cys Leu Lys Gly Pro Ser Ala Asp Val Tyr Lys Ala Lys Cys Glu
225                 230                 235                 240 
Ile Gln Glu Lys Val Tyr Thr Met Ala Gln Lys Asn Ile Gln Val Ser
                245                 250                 255     
Pro Glu Ile Phe Gln Phe Leu Gln Gln Val Asn Trp Lys Glu Phe Ser
            260                 265                 270         
Lys Cys Leu Phe Ile Ala Gln Lys Ile Leu Ala Leu Tyr Glu Leu Glu
        275                 280                 285             
Gly Thr Thr Val Leu Leu Thr Ser Cys Ser Ser Glu Ala Leu Leu Glu
    290                 295                 300                 
Ala Glu Lys Gln Met Leu Ser Ala Leu Asn Tyr Lys Arg Ile Glu Val
305                 310                 315                 320 
Glu Asn Lys Glu Val Leu His Gly Lys Lys Trp Lys Gly Leu Thr His
                325                 330                 335     
Asn Leu Leu Lys Lys Gln Asn Ser Ser Pro Asn Thr Val Ile Ile Asn
            340                 345                 350         
Glu Leu Thr Ser Glu Thr Thr Ala Glu Val Ile Ile Thr Gly Cys Val
        355                 360                 365             
Lys Glu Val Asn Glu Thr Tyr Lys Leu Leu Phe Asn Phe Val Glu Gln
    370                 375                 380                 
Asn Met Lys Ile Glu Arg Leu Val Glu Val Lys Pro Ser Leu Val Ile
385                 390                 395                 400 
Asp Tyr Leu Lys Thr Glu Lys Lys Leu Phe Trp Pro Lys Ile Lys Lys
                405                 410                 415     
Val Asn Val Gln Val Ser Phe Asn Pro Glu Asn Lys Gln Lys Gly Ile
            420                 425                 430         
Leu Leu Thr Gly Ser Lys Thr Glu Val Leu Lys Ala Val Asp Ile Val
        435                 440                 445             
Lys Gln Val Trp Asp Ser Val Cys Val Lys Ser Val His Thr Asp Lys
    450                 455                 460                 
Pro Gly Ala Lys Gln Phe Phe Gln Asp Lys Ala Arg Phe Tyr Gln Ser
465                 470                 475                 480 
Glu Ile Lys Arg Leu Phe Gly Cys Tyr Ile Glu Leu Gln Glu Asn Glu
                485                 490                 495     
Val Met Lys Glu Gly Gly Ser Pro Ala Gly Gln Lys Cys Phe Ser Arg
            500                 505                 510         
Thr Val Leu Ala Pro Gly Val Val Leu Ile Val Gln Gln Gly Asp Leu
        515                 520                 525             
Ala Arg Leu Pro Val Asp Val Val Val Asn Ala Ser Asn Glu Asp Leu
    530                 535                 540                 
Lys His Tyr Gly Gly Leu Ala Ala Ala Leu Ser Lys Ala Ala Gly Pro
545                 550                 555                 560 
Glu Leu Gln Ala Asp Cys Asp Gln Ile Val Lys Arg Glu Gly Arg Leu
                565                 570                 575     
Leu Pro Gly Asn Ala Thr Ile Ser Lys Ala Gly Lys Leu Pro Tyr His
            580                 585                 590         
His Val Ile His Ala Val Gly Pro Arg Trp Ser Gly Tyr Glu Ala Pro
        595                 600                 605             
Arg Cys Val Tyr Leu Leu Arg Arg Ala Val Gln Leu Ser Leu Cys Leu
    610                 615                 620                 
Ala Glu Lys Tyr Lys Tyr Arg Ser Ile Ala Ile Pro Ala Ile Ser Ser
625                 630                 635                 640 
Gly Val Phe Gly Phe Pro Leu Gly Arg Cys Val Glu Thr Ile Val Ser
                645                 650                 655     
Ala Ile Lys Glu Asn Phe Gln Phe Lys Lys Asp Gly His Cys Leu Lys
            660                 665                 670         
Glu Ile Tyr Leu Val Asp Val Ser Glu Lys Thr Val Glu Ala Phe Ala
        675                 680                 685             
Glu Ala Val Lys Thr Val Phe Lys Ala Thr Leu Pro Asp Thr Ala Ala
    690                 695                 700                 
Pro Pro Gly Leu Pro Pro Ala Ala Ala Gly Pro Gly Lys Thr Ser Trp
705                 710                 715                 720 
Glu Lys Gly Ser Leu Val Ser Pro Gly Gly Leu Gln Met Leu Leu Val
                725                 730                 735     
Lys Glu Gly Val Gln Asn Ala Lys Thr Asp Val Val Val Asn Ser Val
            740                 745                 750         
Pro Leu Asp Leu Val Leu Ser Arg Gly Pro Leu Ser Lys Ser Leu Leu
        755                 760                 765             
Glu Lys Ala Gly Pro Glu Leu Gln Glu Glu Leu Asp Thr Val Gly Gln
    770                 775                 780                 
Gly Val Ala Val Ser Met Gly Thr Val Leu Lys Thr Ser Ser Trp Asn
785                 790                 795                 800 
Leu Asp Cys Arg Tyr Val Leu His Val Val Ala Pro Glu Trp Arg Asn
                805                 810                 815     
Gly Ser Thr Ser Ser Leu Lys Ile Met Glu Asp Ile Ile Arg Glu Cys
            820                 825                 830         
Met Glu Ile Thr Glu Ser Leu Ser Leu Lys Ser Ile Ala Phe Pro Ala
        835                 840                 845             
Ile Gly Thr Gly Asn Leu Gly Phe Pro Lys Asn Ile Phe Ala Glu Leu
    850                 855                 860                 
Ile Ile Ser Glu Val Phe Lys Phe Ser Ser Lys Asn Gln Leu Lys Thr
865                 870                 875                 880 
Leu Gln Glu Val His Phe Leu Leu His Pro Ser Asp His Glu Asn Ile
                885                 890                 895     
Gln Ala Phe Ser Asp Glu Phe Ala Arg Arg Ala Asn Gly Asn Leu Val
            900                 905                 910         
Ser Asp Lys Ile Pro Lys Ala Lys Asp Thr Gln Gly Phe Tyr Gly Thr
        915                 920                 925             
Val Ser Ser Pro Asp Ser Gly Val Tyr Glu Met Lys Ile Gly Ser Ile
    930                 935                 940                 
Ile Phe Gln Val Ala Ser Gly Asp Ile Thr Lys Glu Glu Ala Asp Val
945                 950                 955                 960 
Ile Val Asn Ser Thr Ser Asn Ser Phe Asn Leu Lys Ala Gly Val Ser
                965                 970                 975     
Lys Ala Ile Leu Glu Cys Ala Gly Gln Asn Val Glu Arg Glu Cys Ser
            980                 985                 990         
Gln Gln Ala Gln Gln Arg Lys Asn Asp Tyr Ile Ile Thr Gly Gly Gly
        995                 1000                1005            
Phe Leu Arg Cys Lys Asn Ile Ile His Val Ile Gly Gly Asn Asp Val
    1010                1015                1020                
Lys Ser Ser Val Ser Ser Val Leu Gln Glu Cys Glu Lys Lys Asn Tyr
1025                1030                1035                1040
Ser Ser Ile Cys Leu Pro Ala Ile Gly Thr Gly Asn Ala Lys Gln His
                1045                1050                1055    
Pro Asp Lys Val Ala Glu Ala Ile Ile Asp Ala Ile Glu Asp Phe Val
            1060                1065                1070        
Gln Lys Gly Ser Ala Gln Ser Val Lys Lys Val Lys Val Val Ile Phe
        1075                1080                1085            
Leu Pro Gln Val Leu Asp Val Phe Tyr Ala Asn Met Lys Lys Arg Glu
    1090                1095                1100                
Gly Thr Gln Leu Ser Ser Gln Gln Ser Val Met Ser Lys Leu Ala Ser
1105                1110                1115                1120
Phe Leu Gly Phe Ser Lys Gln Ser Pro Gln Lys Lys Asn His Leu Val
                1125                1130                1135    
Leu Glu Lys Lys Thr Glu Ser Ala Thr Phe Arg Val Cys Gly Glu Asn
            1140                1145                1150        
Val Thr Cys Val Glu Tyr Ala Ile Ser Trp Leu Gln Asp Leu Ile Glu
        1155                1160                1165            
Lys Glu Gln Cys Pro Tyr Thr Ser Glu Asp Glu Cys Ile Lys Asp Phe
    1170                1175                1180                
Asp Glu Lys Glu Tyr Gln Glu Leu Asn Glu Leu Gln Lys Lys Leu Asn
1185                1190                1195                1200
Ile Asn Ile Ser Leu Asp His Lys Arg Pro Leu Ile Lys Val Leu Ala
                1205                1210                1215    
Ile Ser Arg Asp Val Met Gln Ala Arg Asp Glu Ile Glu Ala Met Ile
            1220                1225                1230        
Lys Arg Val Arg Leu Gly Lys Glu Gln Glu Ser Arg Ala Asp Cys Ile
        1235                1240                1245            
Ser Glu Phe Ile Glu Trp Gln Tyr Asn Asp Asn Asn Thr Ser His Cys
    1250                1255                1260                
Phe Asn Lys Met Thr Asn Leu Lys Leu Glu Asp Ala Arg Arg Glu Lys
1265                1270                1275                1280
Lys Lys Thr Val Asp Val Lys Ile Asn His Arg His Tyr Thr Val Asn
                1285                1290                1295    
Leu Asn Thr Tyr Thr Ala Thr Asp Thr Lys Gly His Ser Leu Ser Val
            1300                1305                1310        
Gln Arg Leu Thr Lys Ser Lys Val Asp Ile Pro Ala His Trp Ser Asp
        1315                1320                1325            
Met Lys Gln Gln Asn Phe Cys Val Val Glu Leu Leu Pro Ser Asp Pro
    1330                1335                1340                
Glu Tyr Asn Thr Val Ala Ser Lys Phe Asn Gln Thr Cys Ser His Phe
1345                1350                1355                1360
Arg Ile Glu Lys Ile Glu Arg Ile Gln Asn Pro Asp Leu Trp Asn Ser
                1365                1370                1375    
Tyr Gln Ala Lys Lys Lys Thr Met Asp Ala Lys Asn Gly Gln Thr Met
            1380                1385                1390        
Asn Glu Lys Gln Leu Phe His Gly Thr Asp Ala Gly Ser Val Pro His
        1395                1400                1405            
Val Asn Arg Asn Gly Phe Asn Arg Ser Tyr Ala Gly Lys Asn Ala Val
    1410                1415                1420                
Ala Tyr Gly Lys Gly Thr Tyr Phe Ala Val Asn Ala Asn Tyr Ser Ala
1425                1430                1435                1440
Asn Asp Thr Tyr Ser Arg Pro Asp Ala Asn Gly Arg Lys His Val Tyr
                1445                1450                1455    
Tyr Val Arg Val Leu Thr Gly Ile Tyr Thr His Gly Asn His Ser Leu
            1460                1465                1470        
Ile Val Pro Pro Ser Lys Asn Pro Gln Asn Pro Thr Asp Leu Tyr Asp
        1475                1480                1485            
Thr Val Thr Asp Asn Val His His Pro Ser Leu Phe Val Ala Phe Tyr
    1490                1495                1500                
Asp Tyr Gln Ala Tyr Pro Glu Tyr Leu Ile Thr Phe Arg Lys
1505                1510                1515            


<210> 6139
<211> 626
<212> PRT
<213> Homo sapiens

<400> 6139
Met Ser Arg Ser Gly Ala Ala Ala Glu Lys Ala Asp Ser Arg Gln Arg
 1               5                  10                  15      
Pro Gln Met Lys Val Asn Glu Tyr Lys Glu Asn Gln Asn Ile Ala Tyr
            20                  25                  30          
Val Ser Leu Arg Pro Ala Gln Thr Thr Val Leu Ile Lys Thr Ala Lys
        35                  40                  45              
Val Tyr Leu Ala Pro Phe Ser Leu Ser Asn Tyr Gln Leu Asp Gln Leu
    50                  55                  60                  
Met Cys Pro Lys Ser Leu Ser Glu Lys Asn Ser Asn Asn Glu Val Ala
65                  70                  75                  80  
Cys Lys Lys Thr Lys Ile Lys Lys Thr Cys Arg Arg Ile Ile Pro Pro
                85                  90                  95      
Lys Met Lys Asn Thr Ser Ser Lys Ala Glu Ser Thr Leu Gln Asn Ser
            100                 105                 110         
Ser Ser Ala Val His Thr Glu Ser Asn Lys Leu Gln Pro Lys Arg Thr
        115                 120                 125             
Ala Asp Ala Met Asn Leu Ser Val Asp Val Glu Ser Ser Gln Asp Gly
    130                 135                 140                 
Asp Ser Asp Glu Asp Thr Thr Pro Ala Leu Asp Phe Ser Gly Leu Ser
145                 150                 155                 160 
Pro Tyr Glu Arg Lys Arg Leu Lys Asn Ile Ser Glu Asn Ala Asp Phe
                165                 170                 175     
Phe Ala Ser Leu Gln Leu Ser Glu Ser Ala Ala Arg Leu Arg Glu Met
            180                 185                 190         
Ile Glu Lys Arg Gln Pro Pro Lys Ser Lys Arg Lys Lys Pro Lys Arg
        195                 200                 205             
Glu Asn Gly Ile Gly Cys Arg Arg Ser Met Arg Leu Leu Lys Val Asp
    210                 215                 220                 
Pro Ser Gly Val Ser Leu Pro Ala Ala Pro Thr Pro Pro Thr Leu Val
225                 230                 235                 240 
Ala Asp Glu Thr Pro Leu Leu Pro Pro Gly Pro Leu Glu Met Thr Ser
                245                 250                 255     
Glu Asn Gln Glu Asp Asn Asn Glu Arg Phe Lys Gly Phe Leu His Thr
            260                 265                 270         
Trp Ala Gly Met Ser Lys Pro Ser Ser Lys Asn Thr Glu Lys Gly Leu
        275                 280                 285             
Ser Ser Ile Lys Ser Tyr Lys Ala Asn Leu Asn Gly Met Val Ile Ser
    290                 295                 300                 
Glu Asp Thr Val Tyr Lys Val Thr Thr Gly Pro Ile Phe Ser Met Ala
305                 310                 315                 320 
Leu His Pro Ser Glu Thr Arg Thr Leu Val Ala Val Gly Ala Lys Phe
                325                 330                 335     
Gly Gln Val Gly Leu Cys Asp Leu Thr Gln Gln Pro Lys Glu Asp Gly
            340                 345                 350         
Val Tyr Val Phe His Pro His Ser Gln Pro Val Ser Cys Leu Tyr Phe
        355                 360                 365             
Ser Pro Ala Asn Pro Ala His Ile Leu Ser Leu Ser Tyr Asp Gly Thr
    370                 375                 380                 
Leu Arg Cys Gly Asp Phe Ser Arg Ala Ile Phe Glu Glu Val Tyr Arg
385                 390                 395                 400 
Asn Glu Arg Ser Ser Phe Ser Ser Phe Asp Phe Leu Ala Glu Asp Ala
                405                 410                 415     
Ser Thr Leu Ile Val Gly His Trp Asp Gly Asn Met Ser Leu Val Asp
            420                 425                 430         
Arg Arg Thr Pro Gly Thr Ser Tyr Glu Lys Leu Thr Ser Ser Ser Met
        435                 440                 445             
Gly Lys Ile Arg Thr Val His Val His Pro Val His Arg Gln Tyr Phe
    450                 455                 460                 
Ile Thr Ala Gly Leu Arg Asp Thr His Ile Tyr Asp Ala Arg Arg Leu
465                 470                 475                 480 
Asn Ser Arg Arg Ser Gln Pro Leu Ile Ser Leu Thr Glu His Thr Lys
                485                 490                 495     
Ser Ile Ala Ser Ala Tyr Phe Ser Pro Leu Thr Gly Asn Arg Val Val
            500                 505                 510         
Thr Thr Cys Ala Asp Cys Asn Leu Arg Ile Phe Asp Ser Ser Cys Ile
        515                 520                 525             
Ser Ser Lys Ile Pro Leu Leu Thr Thr Ile Arg His Asn Thr Phe Thr
    530                 535                 540                 
Gly Arg Trp Leu Thr Arg Phe Gln Ala Met Trp Asp Pro Lys Gln Glu
545                 550                 555                 560 
Asp Cys Val Ile Val Gly Ser Met Ala His Pro Arg Arg Val Glu Ile
                565                 570                 575     
Phe His Glu Thr Gly Lys Arg Val His Ser Phe Gly Gly Glu Tyr Leu
            580                 585                 590         
Val Ser Val Cys Ser Ile Asn Ala Met His Pro Thr Arg Tyr Ile Leu
        595                 600                 605             
Ala Gly Gly Asn Ser Ser Gly Lys Ile His Val Phe Met Asn Glu Lys
    610                 615                 620                 
Ser Cys
625     


<210> 6140
<211> 343
<212> PRT
<213> Homo sapiens

<400> 6140
Met Pro Pro Leu Ser Thr Ile Asp Pro Ser Gly Thr Arg Ser Lys Asn
 1               5                  10                  15      
Met Pro Ile Lys Asp Asn Ala Leu Val Met Phe Asn Gly Lys Val Tyr
            20                  25                  30          
Leu Leu Ala Lys Lys Gly Thr Asp Val Leu Pro Ser Gln Ile Asp Gln
        35                  40                  45              
Gln Asn Ser Val Ser Pro Asp Thr Pro Val Arg Lys Asp Thr Leu Gln
    50                  55                  60                  
Thr Val Ser Ser Ser Pro Val Thr Glu Ile Ser Arg Glu Val Val Asn
65                  70                  75                  80  
Ile Val Leu Ala Lys Ser Lys Ser Ser Gln Met Glu Thr Lys Ser Leu
                85                  90                  95      
Ser Asn Thr Gln Leu Ala Ser Met Ala Asn Leu Arg Ala Glu Lys Asn
            100                 105                 110         
Lys Val Glu Lys Pro Ser Pro Ser Thr Thr Asn Pro His Met Asn Gln
        115                 120                 125             
Ser Ser Asn Tyr Leu Lys Gln Ser Lys Thr Leu Phe Thr Asn Pro Ile
    130                 135                 140                 
Phe Pro Val Gly Phe Ser Thr Gly His Asn Ala Pro Arg Lys Val Thr
145                 150                 155                 160 
Ala Val Ile Tyr Ala Arg Lys Gly Ser Val Leu Gln Ser Ile Glu Lys
                165                 170                 175     
Ile Ser Ser Ser Val Asp Ala Thr Thr Val Thr Ser Gln Gln Cys Val
            180                 185                 190         
Phe Arg Asp Gln Glu Pro Lys Ile His Asn Glu Met Ala Ser Thr Ser
        195                 200                 205             
Asp Lys Gly Ala Gln Gly Arg Asn Asp Lys Lys Asp Ser Gln Gly Arg
    210                 215                 220                 
Ser Asn Lys Ala Leu His Leu Lys Ser Asp Ala Glu Phe Lys Lys Ile
225                 230                 235                 240 
Phe Gly Leu Thr Lys Asp Leu Arg Val Cys Leu Thr Arg Ile Pro Asp
                245                 250                 255     
His Leu Thr Ser Gly Glu Gly Phe Asp Ser Phe Ser Ser Leu Val Lys
            260                 265                 270         
Ser Gly Thr Tyr Lys Glu Thr Glu Phe Met Val Lys Glu Gly Glu Arg
        275                 280                 285             
Lys Gln Gln Asn Phe Asp Lys Lys Arg Lys Ala Lys Thr Asn Lys Lys
    290                 295                 300                 
Met Asp His Ile Lys Lys Arg Lys Thr Glu Asn Ala Tyr Asn Ala Ile
305                 310                 315                 320 
Ile Asn Gly Glu Ala Asn Val Thr Gly Ser Gln Leu Gln Tyr Phe Thr
                325                 330                 335     
Asn Phe Arg Cys Val Thr Thr
            340             


<210> 6141
<211> 742
<212> PRT
<213> Homo sapiens

<400> 6141
Met Tyr Gln Val Val Gln Thr Ile Gly Ser Asp Gly Lys Asn Leu Leu
 1               5                  10                  15      
Gln Leu Leu Pro Ile Pro Lys Ser Ser Gly Asn Leu Ile Pro Leu Val
            20                  25                  30          
Gln Ser Ser Val Met Ser Asp Ala Leu Lys Gly Asn Thr Gly Lys Pro
        35                  40                  45              
Val Gln Val Thr Phe Gln Thr Gln Ile Ser Ser Ser Ser Thr Ser Ala
    50                  55                  60                  
Ser Val Gln Leu Pro Ile Phe Gln Pro Ala Ser Ser Ser Asn Tyr Phe
65                  70                  75                  80  
Leu Thr Arg Thr Val Asp Thr Ser Glu Lys Gly Arg Val Thr Ser Val
                85                  90                  95      
Gly Thr Gly Asn Phe Ser Ser Ser Val Ser Lys Val Gln Ser His Gly
            100                 105                 110         
Val Lys Ile Asp Gly Leu Thr Met Gln Thr Phe Ala Val Pro Pro Ser
        115                 120                 125             
Thr Gln Lys Asp Ser Ser Phe Ile Val Val Asn Thr Gln Ser Leu Pro
    130                 135                 140                 
Val Thr Val Lys Ser Pro Val Leu Pro Ser Gly His His Leu Gln Ile
145                 150                 155                 160 
Pro Ala His Ala Glu Val Lys Ser Val Pro Ala Ser Ser Leu Pro Pro
                165                 170                 175     
Ser Val Gln Gln Lys Ile Leu Ala Thr Ala Thr Thr Ser Thr Ser Gly
            180                 185                 190         
Met Val Glu Ala Ser Gln Met Pro Thr Val Ile Tyr Val Ser Pro Val
        195                 200                 205             
Asn Thr Val Lys Asn Val Val Thr Lys Asn Phe Gln Asn Ile Tyr Pro
    210                 215                 220                 
Lys Pro Val Thr Glu Ile Ala Lys Pro Val Ile Leu Asn Thr Thr Gln
225                 230                 235                 240 
Ile Pro Lys Asn Val Ala Thr Glu Thr Gln Leu Lys Gly Gly Gln His
                245                 250                 255     
Ser Gln Ala Ala Pro Val Lys Trp Ile Phe Gln Asp Asn Leu Gln Pro
            260                 265                 270         
Phe Thr Pro Ser Leu Val Pro Val Lys Ser Ser Asn Asn Val Ala Ser
        275                 280                 285             
Lys Ile Leu Lys Thr Phe Val Asp Arg Lys Asn Leu Gly Asp Asn Thr
    290                 295                 300                 
Ile Asn Met Pro Pro Leu Ser Thr Ile Asp Pro Ser Gly Thr Arg Ser
305                 310                 315                 320 
Lys Asn Met Pro Ile Lys Asp Asn Ala Leu Val Met Phe Asn Gly Lys
                325                 330                 335     
Val Tyr Leu Leu Ala Lys Lys Gly Thr Asp Val Leu Pro Ser Gln Ile
            340                 345                 350         
Asp Gln Gln Asn Ser Val Ser Pro Asp Thr Pro Val Arg Lys Asp Thr
        355                 360                 365             
Leu Gln Thr Val Ser Ser Ser Pro Val Thr Glu Ile Ser Arg Glu Val
    370                 375                 380                 
Val Asn Ile Val Leu Ala Lys Ser Lys Ser Ser Gln Met Glu Thr Lys
385                 390                 395                 400 
Ser Leu Ser Asn Thr Gln Leu Ala Ser Met Ala Asn Leu Arg Ala Glu
                405                 410                 415     
Lys Asn Lys Val Glu Lys Pro Ser Pro Ser Thr Thr Asn Pro His Met
            420                 425                 430         
Asn Gln Ser Ser Asn Tyr Leu Lys Gln Ser Lys Thr Leu Phe Thr Asn
        435                 440                 445             
Pro Ile Phe Pro Val Gly Phe Ser Thr Gly His Asn Ala Pro Arg Lys
    450                 455                 460                 
Val Thr Ala Val Ile Tyr Ala Arg Lys Gly Ser Val Leu Gln Ser Ile
465                 470                 475                 480 
Glu Lys Ile Ser Ser Ser Val Asp Ala Thr Thr Val Thr Ser Gln Gln
                485                 490                 495     
Cys Val Phe Arg Asp Gln Glu Pro Lys Ile His Asn Glu Met Ala Ser
            500                 505                 510         
Thr Ser Asp Lys Gly Ala Gln Gly Arg Asn Asp Lys Lys Asp Ser Gln
        515                 520                 525             
Gly Arg Ser Asn Lys Ala Leu His Leu Lys Ser Asp Ala Glu Phe Lys
    530                 535                 540                 
Lys Ile Phe Gly Leu Thr Lys Asp Leu Arg Val Cys Leu Thr Arg Ile
545                 550                 555                 560 
Pro Asp His Leu Thr Ser Gly Glu Gly Phe Asp Ser Phe Ser Ser Leu
                565                 570                 575     
Val Lys Ser Gly Thr Tyr Lys Glu Thr Glu Phe Met Val Lys Glu Gly
            580                 585                 590         
Glu Arg Lys Gln Gln Asn Phe Asp Lys Lys Arg Lys Ala Lys Thr Asn
        595                 600                 605             
Lys Lys Met Asp His Ile Lys Lys Arg Lys Thr Glu Asn Ala Tyr Asn
    610                 615                 620                 
Ala Ile Ile Asn Gly Glu Ala Asn Val Thr Gly Ser Gln Leu Leu Ser
625                 630                 635                 640 
Ser Ile Leu Pro Thr Ser Asp Val Ser Gln His Asn Ile Leu Thr Ser
                645                 650                 655     
His Ser Lys Thr Arg Gln Glu Lys Arg Thr Glu Met Glu Tyr Tyr Thr
            660                 665                 670         
His Glu Lys Gln Glu Lys Gly Thr Leu Asn Ser Asn Ala Ala Tyr Glu
        675                 680                 685             
Gln Ser His Phe Phe Asn Lys Asn Tyr Thr Glu Asp Ile Phe Pro Val
    690                 695                 700                 
Thr Pro Pro Glu Leu Glu Glu Thr Ile Arg Asp Glu Lys Ile Arg Arg
705                 710                 715                 720 
Leu Lys Gln Val Leu Arg Glu Lys Glu Ala Ala Leu Glu Glu Met Arg
                725                 730                 735     
Lys Lys Met His Gln Lys
            740         


<210> 6142
<211> 123
<212> PRT
<213> Homo sapiens

<400> 6142
Met Glu Phe Leu Glu Ile Gly Gly Ser Lys Pro Phe Arg Ser Tyr Trp
 1               5                  10                  15      
Glu Met Tyr Leu Ser Lys Gly Leu Leu Leu Ile Phe Val Val Asp Ser
            20                  25                  30          
Ala Asp His Ser Arg Leu Pro Glu Ala Lys Lys Tyr Leu His Gln Leu
        35                  40                  45              
Ile Ala Ala Asn Pro Val Leu Pro Leu Val Val Phe Ala Asn Lys Gln
    50                  55                  60                  
Asp Leu Glu Ala Ala Tyr His Ile Thr Asp Ile His Glu Ala Leu Ala
65                  70                  75                  80  
Leu Ser Glu Val Gly Asn Asp Arg Lys Met Phe Leu Phe Gly Thr Tyr
                85                  90                  95      
Leu Thr Lys Asn Gly Ser Glu Ile Pro Ser Thr Met Gln Asp Ala Lys
            100                 105                 110         
Asp Leu Ile Ala Gln Leu Ala Ala Asp Val Gln
        115                 120             


<210> 6143
<211> 466
<212> PRT
<213> Homo sapiens

<400> 6143
Met Trp Pro Gln Pro Arg Leu Pro Pro His Pro Ala Met Ser Glu Lys
 1               5                  10                  15      
Thr Gln Gln Gly Lys Leu Ala Ala Ala Lys Lys Lys Leu Lys Ala Tyr
            20                  25                  30          
Trp Gln Arg Lys Ser Pro Gly Ile Pro Ala Gly Ala Asn Arg Lys Lys
        35                  40                  45              
Lys Ile Asn Gly Ser Ser Pro Asp Thr Ala Thr Ser Gly Gly Tyr His
    50                  55                  60                  
Ser Pro Gly Asp Ser Ala Thr Gly Ile Tyr Gly Glu Gly Arg Ala Ser
65                  70                  75                  80  
Ser Thr Thr Leu Glu Asp Leu Glu Ser Gln Tyr Gln Glu Leu Ala Val
                85                  90                  95      
Ala Leu Asp Ser Ser Ser Ala Ile Ile Ser Gln Leu Thr Glu Asn Ile
            100                 105                 110         
Asn Ser Leu Val Arg Thr Ser Lys Glu Glu Lys Lys His Glu Ile His
        115                 120                 125             
Leu Val Gln Lys Leu Gly Arg Ser Leu Phe Lys Leu Lys Asn Gln Thr
    130                 135                 140                 
Ala Glu Pro Leu Ala Pro Glu Pro Pro Ala Gly Pro Ser Lys Val Glu
145                 150                 155                 160 
Gln Leu Gln Asp Glu Thr Asn His Leu Arg Lys Glu Leu Glu Ser Val
                165                 170                 175     
Gly Arg Gln Leu Gln Ala Glu Val Glu Asn Asn Gln Met Leu Ser Leu
            180                 185                 190         
Leu Asn Arg Arg Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu
        195                 200                 205             
Arg Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu His Glu
    210                 215                 220                 
Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu
225                 230                 235                 240 
Glu Arg Leu Arg Glu His Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg
                245                 250                 255     
Leu Arg Glu His Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Cys
            260                 265                 270         
Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln
        275                 280                 285             
Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu
    290                 295                 300                 
Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu
305                 310                 315                 320 
Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu
                325                 330                 335     
Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu
            340                 345                 350         
Glu Arg Leu Cys Glu Gln Glu Lys Leu Pro Gly Gln Glu Arg Leu Leu
        355                 360                 365             
Glu Glu Val Glu Lys Leu Leu Glu Gln Glu Arg Arg Gln Glu Glu Gln
    370                 375                 380                 
Glu Arg Leu Leu Glu Arg Glu Arg Leu Leu Glu Glu Val Glu Lys Leu
385                 390                 395                 400 
Leu Glu Gln Glu Arg Arg Gln Glu Glu Gln Glu Arg Leu Leu Glu Arg
                405                 410                 415     
Glu Arg Leu Leu Glu Glu Val Glu Lys Leu Leu Glu Gln Glu Arg Arg
            420                 425                 430         
Gln Glu Glu Gln Glu Arg Leu Leu Glu Arg Glu Arg Leu Leu Asp Glu
        435                 440                 445             
Val Glu Glu Leu Leu Asp Glu Val Glu Glu Leu Leu Glu Gln Glu Arg
    450                 455                 460                 
Leu Arg
465     


<210> 6144
<211> 459
<212> PRT
<213> Homo sapiens

<400> 6144
Met Trp Pro Gln Pro Arg Leu Pro Pro His Pro Ala Met Ser Glu Lys
 1               5                  10                  15      
Thr Gln Gln Gly Lys Leu Ala Ala Ala Lys Lys Lys Leu Lys Ala Tyr
            20                  25                  30          
Trp Gln Arg Lys Ser Pro Gly Ile Pro Ala Gly Ala Asn Arg Lys Lys
        35                  40                  45              
Lys Ile Asn Gly Ser Ser Pro Asp Thr Ala Thr Ser Gly Gly Tyr His
    50                  55                  60                  
Ser Pro Gly Asp Ser Ala Thr Gly Ile Tyr Gly Glu Gly Arg Ala Ser
65                  70                  75                  80  
Ser Thr Thr Leu Glu Asp Leu Glu Ser Gln Tyr Gln Glu Leu Ala Val
                85                  90                  95      
Ala Leu Asp Ser Ser Ser Ala Ile Ile Ser Gln Leu Thr Glu Asn Ile
            100                 105                 110         
Asn Ser Leu Val Arg Thr Ser Lys Glu Glu Lys Lys His Glu Ile His
        115                 120                 125             
Leu Val Gln Lys Leu Gly Arg Ser Leu Phe Lys Leu Lys Asn Gln Thr
    130                 135                 140                 
Ala Glu Pro Leu Ala Pro Glu Pro Pro Ala Gly Pro Ser Lys Val Glu
145                 150                 155                 160 
Gln Leu Gln Asp Glu Thr Asn His Leu Arg Lys Glu Leu Glu Ser Val
                165                 170                 175     
Gly Arg Gln Leu Gln Ala Glu Val Glu Asn Asn Gln Met Leu Ser Leu
            180                 185                 190         
Leu Asn Arg Arg Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu
        195                 200                 205             
Arg Glu Gln Glu Glu Arg Gln Arg Glu Gln Glu Asp Arg Leu His Glu
    210                 215                 220                 
Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu
225                 230                 235                 240 
Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu His Glu Glu Arg
                245                 250                 255     
Leu Cys Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg
            260                 265                 270         
Glu Gln Glu Glu Arg Leu His Glu Gln Glu Glu Arg Leu Arg Glu Gln
        275                 280                 285             
Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu His Glu Glu
    290                 295                 300                 
Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu
305                 310                 315                 320 
Cys Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu
                325                 330                 335     
Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu
            340                 345                 350         
Lys Leu Pro Gly Gln Glu Arg Leu Leu Glu Glu Val Glu Lys Leu Leu
        355                 360                 365             
Glu Gln Glu Arg Arg Gln Glu Glu Gln Glu Arg Leu Leu Glu Arg Glu
    370                 375                 380                 
Arg Leu Leu Glu Glu Val Glu Lys Leu Leu Glu Gln Glu Arg Gln Gln
385                 390                 395                 400 
Glu Glu Gln Glu Arg Leu Leu Glu Arg Glu Arg Leu Leu Glu Glu Val
                405                 410                 415     
Glu Lys Leu Leu Glu Gln Glu Arg Arg Gln Glu Glu Gln Glu Arg Leu
            420                 425                 430         
Leu Glu Arg Glu Arg Leu Leu Asp Glu Val Glu Glu Leu Leu Asp Glu
        435                 440                 445             
Val Glu Glu Leu Leu Glu Gln Glu Arg Leu Arg
    450                 455                 


<210> 6145
<211> 383
<212> PRT
<213> Homo sapiens

<400> 6145
Met Trp Pro Gln Pro Arg Leu Pro Pro His Pro Ala Met Ser Glu Lys
 1               5                  10                  15      
Thr Gln Gln Gly Lys Leu Ala Ala Ala Lys Lys Lys Leu Lys Ala Tyr
            20                  25                  30          
Trp Gln Arg Lys Ser Pro Gly Ile Pro Ala Gly Ala Asn Arg Lys Lys
        35                  40                  45              
Lys Ile Asn Gly Ser Ser Pro Asp Thr Ala Thr Ser Gly Gly Tyr His
    50                  55                  60                  
Ser Pro Gly Asp Ser Ala Thr Gly Ile Tyr Gly Glu Gly Arg Ala Ser
65                  70                  75                  80  
Ser Thr Thr Leu Glu Asp Leu Glu Ser Gln Tyr Gln Glu Leu Ala Val
                85                  90                  95      
Ala Leu Asp Ser Ser Ser Ala Ile Ile Ser Gln Leu Thr Glu Asn Ile
            100                 105                 110         
Asn Ser Leu Val Arg Thr Ser Lys Glu Glu Lys Lys His Glu Ile His
        115                 120                 125             
Leu Val Gln Lys Leu Gly Arg Ser Leu Phe Lys Leu Lys Asn Gln Thr
    130                 135                 140                 
Ala Glu Pro Leu Ala Pro Glu Pro Pro Ala Gly Pro Ser Lys Val Glu
145                 150                 155                 160 
Gln Leu Gln Asp Glu Thr Asn His Leu Arg Lys Glu Leu Glu Ser Val
                165                 170                 175     
Gly Arg Gln Leu Gln Ala Glu Val Glu Asn Asn Gln Met Leu Ser Leu
            180                 185                 190         
Leu Asn Arg Arg Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu
        195                 200                 205             
Arg Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu His Glu
    210                 215                 220                 
Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu
225                 230                 235                 240 
Glu Arg Leu Arg Glu His Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg
                245                 250                 255     
Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys
            260                 265                 270         
Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Cys Glu Gln
        275                 280                 285             
Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu
    290                 295                 300                 
Arg Leu Cys Glu His Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu
305                 310                 315                 320 
Arg Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu
                325                 330                 335     
Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu
            340                 345                 350         
Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Val Phe Arg Gln Val Glu
        355                 360                 365             
Leu Lys Ser Gln Glu Ala Pro Ser Leu Gln Gln Gln Pro Asp Gln
    370                 375                 380             


<210> 6146
<211> 509
<212> PRT
<213> Homo sapiens

<400> 6146
Met Ser Glu Lys Thr Gln Gln Gly Lys Leu Ala Ala Ala Lys Lys Lys
 1               5                  10                  15      
Val Lys His Thr Arg Ser Arg Pro Pro Thr Gln Pro Gln Ile Pro Ser
            20                  25                  30          
Asp Asp Lys Thr Gly Ala Arg Val His Thr Thr Pro Glu Ala Tyr Gln
        35                  40                  45              
Met Gly Pro Pro Asn Pro Ser Pro Leu Gly Ser Pro Asn Gln Ser Leu
    50                  55                  60                  
Val Ser Gln Pro His Pro Phe Ser Lys Gln Pro Ser Pro Cys Pro Cys
65                  70                  75                  80  
Gln Ser Pro Gln Gly Asp Phe Gly Gln Glu Asp Val Ala Val Gly Ala
                85                  90                  95      
Asp His Ser His Glu Cys Tyr Arg Ser Ser Phe Pro Gln Leu Lys Ala
            100                 105                 110         
Tyr Trp Gln Arg Lys Ser Pro Gly Ile Pro Ala Gly Ala Asn Arg Lys
        115                 120                 125             
Lys Lys Ile Asn Gly Ser Ser Pro Asp Thr Ala Thr Ser Gly Gly Tyr
    130                 135                 140                 
His Ser Pro Gly Asp Ser Ala Thr Gly Ile Tyr Gly Glu Gly Arg Ala
145                 150                 155                 160 
Ser Ser Thr Thr Leu Glu Asp Leu Glu Ser Gln Tyr Gln Glu Leu Ala
                165                 170                 175     
Val Ala Leu Asp Ser Ser Ser Ala Ile Ile Ser Gln Leu Thr Glu Asn
            180                 185                 190         
Ile Asn Ser Leu Val Arg Thr Ser Lys Glu Glu Lys Lys His Glu Ile
        195                 200                 205             
His Leu Val Gln Lys Leu Gly Arg Ser Leu Phe Lys Leu Lys Asn Gln
    210                 215                 220                 
Thr Ala Glu Pro Leu Ala Pro Glu Pro Pro Ala Gly Pro Ser Lys Val
225                 230                 235                 240 
Glu Gln Leu Gln Asp Glu Thr Asn His Leu Arg Lys Glu Leu Glu Ser
                245                 250                 255     
Val Gly Arg Gln Leu Gln Ala Glu Val Glu Asn Asn Gln Met Leu Ser
            260                 265                 270         
Leu Leu Asn Arg Arg Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg
        275                 280                 285             
Leu Arg Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys
    290                 295                 300                 
Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Arg Glu Gln
305                 310                 315                 320 
Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu His Glu Glu
                325                 330                 335     
Arg Leu Cys Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu
            340                 345                 350         
Arg Glu Gln Glu Glu Arg Leu His Glu Gln Glu Glu Arg Leu Cys Glu
        355                 360                 365             
Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu
    370                 375                 380                 
Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg
385                 390                 395                 400 
Leu Arg Glu Gln Glu Glu Arg Leu Leu Arg Gln Gln Asp Glu Arg Leu
                405                 410                 415     
Trp Gln Gln Glu Thr Leu Gln Glu Leu Glu Arg Leu Arg Glu Leu Glu
            420                 425                 430         
Arg Met Leu Glu Leu Gly Trp Glu Ala Leu Tyr Glu Gln Arg Ala Glu
        435                 440                 445             
Pro Arg Ser Gly Phe Glu Glu Leu Asn Asn Glu Asn Lys Ser Thr Leu
    450                 455                 460                 
Gln Leu Glu Gln Gln Val Lys Glu Leu Lys Lys Ser Glu Val Gly Ser
465                 470                 475                 480 
Pro Gly Val Leu Pro Gly Leu Asp Ile Ile Ile Pro Ala Arg Gly Met
                485                 490                 495     
Glu Pro Pro Asn His Arg Ala Glu Glu Glu Thr Val Val
            500                 505                 


<210> 6147
<211> 503
<212> PRT
<213> Homo sapiens

<400> 6147
Met Ser Glu Lys Thr Gln Gln Gly Lys Leu Ala Ala Ala Lys Lys Lys
 1               5                  10                  15      
Leu Lys Ala Tyr Trp Gln Arg Lys Ser Pro Gly Ile Pro Ala Gly Ala
            20                  25                  30          
Asn Arg Lys Lys Lys Ile Asn Gly Ser Ser Pro Asp Thr Ala Thr Ser
        35                  40                  45              
Gly Gly Tyr His Ser Pro Gly Asp Ser Ala Thr Gly Ile Tyr Gly Glu
    50                  55                  60                  
Gly Arg Ala Ser Ser Thr Thr Leu Glu Asp Leu Glu Ser Gln Tyr Gln
65                  70                  75                  80  
Glu Leu Ala Val Ala Leu Asp Ser Ser Ser Ala Ile Ile Ser Gln Leu
                85                  90                  95      
Thr Glu Asn Ile Asn Ser Leu Val Arg Thr Ser Lys Glu Glu Lys Lys
            100                 105                 110         
His Glu Ile His Leu Val Gln Lys Leu Gly Arg Ser Leu Phe Lys Leu
        115                 120                 125             
Lys Asn Gln Thr Ala Glu Pro Leu Ala Pro Glu Pro Pro Ala Gly Pro
    130                 135                 140                 
Ser Lys Val Glu Gln Leu Gln Asp Glu Thr Asn His Leu Arg Lys Glu
145                 150                 155                 160 
Leu Glu Ser Val Gly Arg Gln Leu Gln Ala Glu Val Glu Asn Asn Gln
                165                 170                 175     
Met Leu Ser Leu Leu Asn Arg Arg Gln Glu Glu Arg Leu Arg Glu Gln
            180                 185                 190         
Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Asp
        195                 200                 205             
Arg Leu His Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu
    210                 215                 220                 
Cys Glu Gln Glu Glu Arg Leu Arg Glu His Glu Glu Arg Leu Cys Glu
225                 230                 235                 240 
Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu
                245                 250                 255     
Glu Arg Leu His Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg
            260                 265                 270         
Leu Cys Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys
        275                 280                 285             
Glu Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln
    290                 295                 300                 
Glu Lys Leu Pro Gly Gln Glu Arg Leu Leu Glu Glu Val Glu Lys Leu
305                 310                 315                 320 
Leu Glu Gln Glu Arg Arg Gln Glu Glu Gln Glu Arg Leu Leu Glu Arg
                325                 330                 335     
Glu Arg Leu Leu Glu Glu Val Glu Lys Leu Leu Glu Gln Glu Arg Leu
            340                 345                 350         
Arg Gln Gln Asp Glu Arg Leu Trp Gln Gln Glu Thr Leu Gln Glu Leu
        355                 360                 365             
Glu Arg Leu Arg Glu Leu Glu Arg Leu Arg Glu Leu Glu Arg Met Leu
    370                 375                 380                 
Glu Leu Gly Trp Glu Ala Leu Tyr Glu Gln Arg Ala Glu Pro Arg Ser
385                 390                 395                 400 
Gly Phe Glu Glu Leu Asn Asn Glu Asn Lys Ser Thr Leu Gln Leu Glu
                405                 410                 415     
Gln Gln Val Lys Glu Leu Lys Lys Ser Gly Gly Ala Glu Glu Pro Arg
            420                 425                 430         
Gly Ser Glu Ser Ala Ala Ala Ala Arg Pro Val Ala Gly Ala Pro Val
        435                 440                 445             
Pro Gln Gly Ala Trp Met Cys Gly Gln Ala Gly Trp Thr Pro Gln Glu
    450                 455                 460                 
His Pro Gly Leu Ser Gly Glu Ala Val Gly Thr Gly Glu Ala Ala Gly
465                 470                 475                 480 
Gly Ala Gly Glu Ala Ala Cys His Ser Phe Arg Ala Ala Glu Asn Arg
                485                 490                 495     
Glu Leu Asn Ile Thr Ile Ile
            500             


<210> 6148
<211> 1723
<212> PRT
<213> Homo sapiens

<400> 6148
Met Arg Glu Lys Glu Gln Glu Arg Glu Glu Gln Leu Met Glu Asp Lys
 1               5                  10                  15      
Lys Arg Lys Lys Glu Asp Lys Lys Lys Lys Glu Ala Thr Gln Lys Val
            20                  25                  30          
Thr Glu Gln Lys Thr Lys Val Pro Glu Val Thr Lys Pro Ser Leu Ser
        35                  40                  45              
Gln Pro Thr Ala Ala Ser Pro Ile Gly Ser Ser Pro Ser Pro Pro Val
    50                  55                  60                  
Asn Gly Gly Asn Asn Ala Lys Arg Val Ala Val Pro Asn Gly Gln Pro
65                  70                  75                  80  
Pro Ser Ala Ala Arg Tyr Met Pro Arg Glu Val Pro Pro Arg Phe Arg
                85                  90                  95      
Cys Gln Gln Asp His Lys Val Leu Leu Lys Arg Gly Gln Pro Pro Pro
            100                 105                 110         
Pro Ser Cys Met Leu Leu Gly Gly Gly Ala Gly Pro Pro Pro Cys Thr
        115                 120                 125             
Ala Pro Gly Ala Asn Pro Asn Asn Ala Gln Val Thr Gly Ala Leu Leu
    130                 135                 140                 
Gln Ser Glu Ser Gly Thr Ala Pro Asp Ser Thr Leu Gly Gly Ala Ala
145                 150                 155                 160 
Ala Ser Asn Tyr Ala Asn Ser Thr Trp Gly Ser Gly Ala Ser Ser Asn
                165                 170                 175     
Asn Gly Thr Ser Pro Asn Pro Ile His Ile Trp Asp Lys Val Ile Val
            180                 185                 190         
Asp Gly Ser Asp Met Glu Glu Trp Pro Cys Ile Ala Ser Lys Asp Thr
        195                 200                 205             
Glu Ser Ser Ser Glu Asn Thr Thr Asp Asn Asn Ser Ala Ser Asn Pro
    210                 215                 220                 
Gly Ser Glu Lys Ser Thr Leu Pro Gly Ser Thr Thr Ser Asn Lys Gly
225                 230                 235                 240 
Lys Gly Ser Gln Cys Gln Ser Ala Ser Ser Gly Asn Glu Cys Asn Leu
                245                 250                 255     
Gly Val Trp Lys Ser Asp Pro Lys Ala Lys Ser Val Gln Ser Ser Asn
            260                 265                 270         
Ser Thr Thr Glu Asn Asn Asn Gly Leu Gly Asn Trp Arg Asn Val Ser
        275                 280                 285             
Gly Gln Asp Arg Ile Gly Pro Gly Ser Gly Phe Ser Asn Phe Asn Pro
    290                 295                 300                 
Asn Ser Asn Pro Ser Ala Trp Pro Ala Leu Val Gln Glu Gly Thr Ser
305                 310                 315                 320 
Arg Lys Gly Ala Leu Glu Thr Asp Asn Ser Asn Ser Ser Ala Gln Val
                325                 330                 335     
Ser Thr Val Gly Gln Thr Ser Arg Glu Gln Gln Ser Lys Met Glu Asn
            340                 345                 350         
Ala Gly Val Asn Phe Val Val Ser Gly Arg Glu Gln Ala Gln Ile His
        355                 360                 365             
Asn Thr Asp Gly Pro Lys Asn Gly Asn Thr Asn Ser Leu Asn Leu Ser
    370                 375                 380                 
Ser Pro Asn Pro Met Glu Asn Lys Gly Met Pro Phe Gly Met Gly Leu
385                 390                 395                 400 
Gly Asn Thr Ser Arg Ser Thr Asp Ala Pro Ser Gln Ser Thr Gly Asp
                405                 410                 415     
Arg Lys Thr Gly Ser Val Gly Ser Trp Gly Ala Ala Arg Gly Pro Ser
            420                 425                 430         
Gly Thr Asp Thr Val Ser Gly Gln Ser Asn Ser Gly Asn Asn Gly Asn
        435                 440                 445             
Asn Gly Lys Glu Arg Glu Asp Ser Trp Lys Gly Ala Ser Val Gln Lys
    450                 455                 460                 
Ser Thr Gly Ser Lys Asn Asp Ser Trp Asp Asn Asn Asn Arg Ser Thr
465                 470                 475                 480 
Gly Gly Ser Trp Asn Phe Gly Pro Gln Asp Ser Asn Asp Asn Lys Trp
                485                 490                 495     
Gly Glu Gly Asn Lys Met Thr Ser Gly Val Ser Gln Gly Glu Trp Lys
            500                 505                 510         
Gln Pro Thr Gly Ser Asp Glu Leu Lys Ile Gly Glu Trp Ser Gly Pro
        515                 520                 525             
Asn Gln Pro Asn Ser Ser Thr Gly Ala Trp Asp Asn Gln Lys Gly His
    530                 535                 540                 
Pro Leu Pro Glu Asn Gln Gly Asn Ala Gln Ala Pro Cys Trp Gly Arg
545                 550                 555                 560 
Ser Ser Ser Ser Thr Gly Ser Glu Val Gly Gly Gln Ser Thr Gly Ser
                565                 570                 575     
Asn His Lys Ala Gly Ser Ser Asp Ser His Asn Ser Gly Arg Arg Ser
            580                 585                 590         
Tyr Arg Pro Thr His Pro Asp Cys Gln Ala Val Leu Gln Thr Leu Leu
        595                 600                 605             
Ser Arg Thr Asp Leu Asp Pro Arg Val Leu Ser Asn Thr Gly Trp Gly
    610                 615                 620                 
Gln Thr Gln Ile Lys Gln Asp Thr Val Trp Asp Ile Glu Glu Val Pro
625                 630                 635                 640 
Arg Pro Glu Gly Lys Ser Asp Lys Gly Thr Glu Gly Trp Glu Ser Ala
                645                 650                 655     
Ala Thr Gln Thr Lys Asn Ser Gly Gly Trp Gly Asp Ala Pro Ser Gln
            660                 665                 670         
Ser Asn Gln Met Lys Ser Gly Trp Gly Glu Leu Ser Ala Ser Thr Glu
        675                 680                 685             
Trp Lys Asp Pro Lys Asn Thr Gly Gly Trp Asn Asp Tyr Lys Asn Asn
    690                 695                 700                 
Asn Ser Ser Asn Trp Gly Gly Gly Arg Pro Asp Glu Lys Thr Pro Ser
705                 710                 715                 720 
Ser Trp Asn Glu Asn Pro Ser Lys Asp Gln Gly Trp Gly Gly Gly Arg
                725                 730                 735     
Gln Pro Asn Gln Gly Trp Ser Ser Gly Lys Asn Gly Trp Gly Glu Glu
            740                 745                 750         
Val Asp Gln Thr Lys Asn Ser Asn Trp Glu Ser Ser Ala Ser Lys Pro
        755                 760                 765             
Val Ser Gly Trp Gly Glu Gly Gly Gln Asn Glu Ile Gly Thr Trp Gly
    770                 775                 780                 
Asn Gly Gly Asn Ala Ser Leu Ala Ser Lys Gly Gly Trp Glu Asp Cys
785                 790                 795                 800 
Lys Arg Ser Pro Ala Trp Asn Glu Thr Gly Arg Gln Pro Asn Ser Trp
                805                 810                 815     
Asn Lys Gln His Gln Gln Gln Gln Pro Pro Gln Gln Pro Pro Pro Pro
            820                 825                 830         
Gln Pro Glu Ala Ser Gly Ser Trp Gly Gly Pro Pro Pro Pro Pro Pro
        835                 840                 845             
Gly Asn Val Arg Pro Ser Asn Ser Ser Trp Ser Ser Gly Pro Gln Pro
    850                 855                 860                 
Ala Thr Pro Lys Asp Glu Glu Pro Ser Gly Trp Glu Glu Pro Ser Pro
865                 870                 875                 880 
Gln Ser Ile Ser Arg Lys Met Asp Ile Asp Asp Gly Thr Ser Ala Trp
                885                 890                 895     
Gly Asp Pro Asn Ser Tyr Asn Tyr Lys Asn Val Asn Leu Trp Asp Lys
            900                 905                 910         
Asn Ser Gln Gly Gly Pro Ala Pro Arg Glu Pro Asn Leu Pro Thr Pro
        915                 920                 925             
Met Thr Ser Lys Ser Ala Ser Asp Ser Lys Ser Met Gln Asp Gly Trp
    930                 935                 940                 
Gly Glu Ser Asp Gly Pro Val Thr Gly Ala Arg His Pro Ser Trp Glu
945                 950                 955                 960 
Glu Glu Glu Asp Gly Gly Val Trp Asn Thr Thr Gly Ser Gln Gly Ser
                965                 970                 975     
Ala Ser Ser His Asn Ser Ala Ser Trp Gly Gln Gly Gly Lys Lys Gln
            980                 985                 990         
Met Lys Cys Ser Leu Lys Gly Gly Asn Asn Asp Ser Trp Met Asn Pro
        995                 1000                1005            
Leu Ala Lys Gln Phe Ser Asn Met Gly Leu Leu Ser Gln Thr Glu Asp
    1010                1015                1020                
Asn Pro Ser Ser Lys Met Asp Leu Ser Val Gly Ser Leu Ser Asp Lys
1025                1030                1035                1040
Lys Phe Asp Val Asp Lys Arg Ala Met Asn Leu Gly Asp Phe Asn Asp
                1045                1050                1055    
Ile Met Arg Lys Asp Arg Ser Gly Phe Arg Pro Pro Asn Ser Lys Asp
            1060                1065                1070        
Met Gly Thr Thr Asp Ser Gly Pro Tyr Phe Glu Lys Gly Gly Ser His
        1075                1080                1085            
Gly Leu Phe Gly Asn Ser Thr Ala Gln Ser Arg Gly Leu His Thr Pro
    1090                1095                1100                
Val Gln Pro Leu Asn Ser Ser Pro Ser Leu Arg Ala Gln Val Pro Pro
1105                1110                1115                1120
Gln Phe Ile Ser Pro Gln Val Ser Ala Ser Met Leu Lys Gln Phe Pro
                1125                1130                1135    
Asn Ser Gly Leu Ser Pro Gly Leu Phe Asn Val Gly Pro Gln Leu Ser
            1140                1145                1150        
Pro Gln Gln Ile Ala Met Leu Ser Gln Leu Pro Gln Ile Pro Gln Phe
        1155                1160                1165            
Gln Leu Ala Cys Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Leu
    1170                1175                1180                
Leu Gln Asn Gln Arg Lys Ile Ser Gln Ala Val Arg Gln Gln Gln Glu
1185                1190                1195                1200
Gln Gln Leu Ala Arg Met Val Ser Ala Leu Gln Gln Gln Gln Gln Gln
                1205                1210                1215    
Gln Gln Arg Gln Pro Gly Met Lys His Ser Pro Ser His Pro Val Gly
            1220                1225                1230        
Pro Lys Pro His Leu Asp Asn Met Val Pro Asn Ala Leu Asn Val Gly
        1235                1240                1245            
Leu Pro Asp Leu Gln Thr Lys Gly Pro Ile Pro Gly Tyr Gly Ser Gly
    1250                1255                1260                
Phe Ser Ser Gly Gly Met Asp Tyr Gly Met Val Gly Gly Lys Glu Ala
1265                1270                1275                1280
Gly Thr Glu Ser Arg Phe Lys Gln Trp Thr Ser Met Met Glu Gly Leu
                1285                1290                1295    
Pro Ser Val Ala Thr Gln Glu Ala Asn Met His Lys Asn Gly Ala Ile
            1300                1305                1310        
Val Ala Pro Gly Lys Thr Arg Gly Gly Ser Pro Tyr Asn Gln Phe Asp
        1315                1320                1325            
Ile Ile Pro Gly Asp Thr Leu Gly Gly His Thr Gly Pro Ala Gly Asp
    1330                1335                1340                
Ser Trp Leu Pro Ala Lys Ser Pro Pro Thr Asn Lys Ile Gly Ser Lys
1345                1350                1355                1360
Ser Ser Asn Ala Ser Trp Pro Pro Glu Phe Gln Pro Gly Val Pro Trp
                1365                1370                1375    
Lys Gly Ile Gln Asn Ile Asp Pro Glu Ser Asp Pro Tyr Val Thr Pro
            1380                1385                1390        
Gly Ser Val Leu Gly Gly Thr Ala Thr Ser Pro Ile Val Asp Thr Asp
        1395                1400                1405            
His Gln Leu Leu Arg Asp Asn Thr Thr Gly Ser Asn Ser Ser Leu Asn
    1410                1415                1420                
Thr Ser Leu Pro Ser Pro Gly Ala Trp Pro Tyr Ser Ala Ser Asp Asn
1425                1430                1435                1440
Ser Phe Thr Asn Val His Ser Thr Ser Ala Lys Phe Pro Asp Tyr Lys
                1445                1450                1455    
Ser Thr Trp Ser Pro Asp Pro Ile Gly His Asn Pro Thr His Leu Ser
            1460                1465                1470        
Asn Lys Met Trp Lys Asn His Ile Ser Ser Arg Asn Thr Thr Pro Leu
        1475                1480                1485            
Pro Arg Pro Pro Pro Gly Leu Thr Asn Pro Lys Pro Ser Ser Pro Trp
    1490                1495                1500                
Ser Ser Thr Ala Pro Arg Ser Val Arg Gly Trp Gly Thr Gln Asp Ser
1505                1510                1515                1520
Arg Leu Ala Ser Ala Ser Thr Trp Ser Asp Gly Gly Ser Val Arg Pro
                1525                1530                1535    
Ser Tyr Trp Leu Val Leu His Asn Leu Thr Pro Gln Ile Asp Gly Ser
            1540                1545                1550        
Thr Leu Arg Thr Ile Cys Met Gln His Gly Pro Leu Leu Thr Phe His
        1555                1560                1565            
Leu Asn Leu Thr Gln Gly Thr Ala Leu Ile Arg Tyr Ser Thr Lys Gln
    1570                1575                1580                
Glu Ala Ala Lys Ala Gln Thr Ala Leu His Met Cys Val Leu Gly Asn
1585                1590                1595                1600
Thr Thr Ile Leu Ala Glu Phe Ala Thr Asp Asp Glu Val Ser Arg Phe
                1605                1610                1615    
Leu Ala Gln Ala Gln Pro Pro Thr Pro Ala Ala Thr Pro Ser Ala Pro
            1620                1625                1630        
Ala Ala Gly Trp Gln Ser Leu Glu Thr Gly Gln Asn Gln Ser Asp Pro
        1635                1640                1645            
Val Gly Pro Ala Leu Asn Leu Phe Gly Gly Ser Thr Gly Leu Gly Gln
    1650                1655                1660                
Trp Ser Ser Ser Ala Gly Gly Ser Ser Gly Ala Asp Leu Ala Gly Ala
1665                1670                1675                1680
Ser Leu Trp Gly Pro Pro Asn Tyr Ser Ser Ser Leu Trp Gly Val Pro
                1685                1690                1695    
Thr Val Glu Asp Pro His Arg Met Gly Ser Pro Ala Pro Leu Leu Pro
            1700                1705                1710        
Gly Asp Leu Leu Gly Gly Gly Ser Asp Ser Ile
        1715                1720            


<210> 6149
<211> 1314
<212> PRT
<213> Homo sapiens

<400> 6149
Met Ala Ser Lys Gly Ala Gly Met Ser Phe Ser Arg Lys Ser Tyr Arg
 1               5                  10                  15      
Leu Thr Ser Asp Ala Glu Lys Ser Arg Val Thr Gly Ile Val Gln Glu
            20                  25                  30          
Lys Leu Leu Asn Asp Tyr Leu Asn Arg Ile Phe Ser Ser Ser Glu His
        35                  40                  45              
Ala Pro Pro Ala Ala Thr Ser Arg Lys Pro Leu Asn Phe Gln Asn Leu
    50                  55                  60                  
Pro Glu His Leu Asp Gln Leu Leu Gln Val Asp Asn Glu Glu Glu Glu
65                  70                  75                  80  
Ser Gln Gly Gln Val Glu Gly Arg Leu Gly Pro Ser Thr Val Val Leu
                85                  90                  95      
Asp His Thr Gly Gly Phe Glu Gly Leu Leu Leu Val Asp Asp Asp Leu
            100                 105                 110         
Leu Gly Val Ile Gly His Ser Asn Phe Gly Thr Ile Arg Ser Thr Thr
        115                 120                 125             
Cys Val Tyr Lys Gly Lys Trp Leu Tyr Glu Val Leu Ile Ser Ser Gln
    130                 135                 140                 
Gly Leu Met Gln Ile Gly Trp Cys Thr Ile Ser Cys Arg Phe Asn Gln
145                 150                 155                 160 
Glu Glu Gly Val Gly Asp Thr His Asn Ser Tyr Ala Tyr Asp Gly Asn
                165                 170                 175     
Arg Val Arg Lys Trp Asn Val Thr Thr Thr Asn Tyr Gly Lys Ala Trp
            180                 185                 190         
Ala Ala Gly Asp Ile Val Ser Cys Leu Ile Asp Leu Asp Asp Gly Thr
        195                 200                 205             
Leu Ser Phe Cys Leu Asn Gly Val Ser Leu Gly Thr Ala Phe Glu Asn
    210                 215                 220                 
Leu Ser Arg Gly Leu Gly Met Ala Tyr Phe Pro Ala Ile Ser Leu Ser
225                 230                 235                 240 
Phe Lys Glu Ser Val Ala Phe Asn Phe Gly Ser Arg Pro Leu Arg Tyr
                245                 250                 255     
Pro Val Ala Gly Tyr Arg Pro Leu Gln Asp Pro Pro Ser Ala Asp Leu
            260                 265                 270         
Val Arg Ala Gln Arg Leu Leu Gly Cys Phe Arg Ala Val Leu Ser Val
        275                 280                 285             
Glu Leu Asp Pro Val Glu Gly Arg Leu Leu Asp Lys Glu Ser Ser Lys
    290                 295                 300                 
Trp Arg Leu Arg Gly Gln Pro Thr Val Leu Leu Thr Leu Ala His Ile
305                 310                 315                 320 
Phe His His Phe Ala Pro Leu Leu Arg Lys Val Tyr Leu Val Glu Ala
                325                 330                 335     
Val Leu Met Ser Phe Leu Leu Gly Ile Val Glu Lys Gly Thr Pro Thr
            340                 345                 350         
Gln Ala Gln Ser Val Val His Gln Val Leu Asp Leu Leu Trp Leu Phe
        355                 360                 365             
Met Glu Asp Tyr Glu Val Gln Asp Cys Leu Lys Gln Leu Met Met Ser
    370                 375                 380                 
Leu Leu Arg Leu Tyr Arg Phe Ser Pro Ile Val Pro Asp Leu Gly Leu
385                 390                 395                 400 
Gln Ile His Tyr Leu Arg Leu Thr Ile Ala Ile Leu Arg His Glu Lys
                405                 410                 415     
Ser Arg Lys Phe Leu Leu Ser Asn Val Leu Phe Asp Val Leu Arg Ser
            420                 425                 430         
Val Val Phe Phe Tyr Ile Lys Ser Pro Leu Arg Val Glu Glu Ala Gly
        435                 440                 445             
Leu Gln Glu Leu Ile Pro Thr Thr Trp Trp Pro His Cys Ser Ser Arg
    450                 455                 460                 
Glu Gly Lys Glu Ser Thr Glu Met Lys Glu Glu Thr Ala Glu Glu Arg
465                 470                 475                 480 
Leu Arg Arg Arg Ala Tyr Glu Arg Gly Cys Gln Arg Leu Arg Lys Arg
                485                 490                 495     
Ile Glu Val Val Glu Glu Leu Gln Val Gln Ile Leu Lys Leu Leu Leu
            500                 505                 510         
Asp Asn Lys Asp Asp Asn Gly Gly Glu Ala Ser Arg Tyr Ile Phe Leu
        515                 520                 525             
Thr Lys Phe Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly Asn
    530                 535                 540                 
Met Pro Met Leu Cys Pro Pro Glu Tyr Met Val Cys Phe Leu His Arg
545                 550                 555                 560 
Leu Ile Ser Ala Leu Arg Tyr Tyr Trp Asp Glu Tyr Lys Ala Ser Asn
                565                 570                 575     
Pro His Ala Ser Phe Ser Glu Glu Ala Tyr Ile Pro Pro Gln Val Phe
            580                 585                 590         
Tyr Asn Gly Lys Val Asp Tyr Phe Asp Leu Gln Arg Leu Gly Gly Leu
        595                 600                 605             
Leu Ser His Leu Arg Lys Thr Leu Lys Asp Asp Leu Ala Ser Lys Ala
    610                 615                 620                 
Asn Ile Val Ile Asp Pro Leu Glu Leu Gln Ser Thr Ala Met Asp Asp
625                 630                 635                 640 
Leu Asp Glu Asp Glu Glu Pro Ala Pro Ala Met Ala Gln Arg Pro Met
                645                 650                 655     
Gln Ala Leu Ala Val Gly Gly Pro Leu Pro Leu Pro Arg Pro Gly Trp
            660                 665                 670         
Leu Ser Ser Pro Thr Leu Gly Arg Ala Asn Arg Phe Leu Ser Thr Ala
        675                 680                 685             
Ala Val Ser Leu Met Thr Pro Arg Arg Pro Leu Ser Thr Ser Glu Lys
    690                 695                 700                 
Val Lys Val Arg Thr Leu Ser Val Glu Gln Arg Thr Arg Glu Asp Ile
705                 710                 715                 720 
Glu Gly Ser His Trp Asn Glu Gly Leu Leu Leu Gly Arg Pro Pro Glu
                725                 730                 735     
Glu Pro Glu Gln Pro Leu Thr Glu Asn Ser Leu Leu Glu Val Leu Asp
            740                 745                 750         
Gly Ala Val Met Met Tyr Asn Leu Ser Val His Gln Gln Leu Gly Lys
        755                 760                 765             
Met Val Gly Val Ser Asp Asp Val Asn Glu Tyr Ala Met Ala Leu Arg
    770                 775                 780                 
Asp Thr Glu Asp Lys Leu Arg Arg Cys Pro Lys Arg Arg Lys Asp Ile
785                 790                 795                 800 
Leu Ala Glu Leu Thr Lys Ser Gln Lys Val Phe Ser Glu Lys Leu Asp
                805                 810                 815     
His Leu Ser Arg Arg Leu Ala Trp Val His Ala Thr Val Tyr Ser Gln
            820                 825                 830         
Glu Lys Met Leu Asp Ile Tyr Trp Leu Leu Arg Val Cys Leu Arg Thr
        835                 840                 845             
Ile Glu His Gly Asp Arg Thr Gly Ser Leu Phe Ala Phe Met Pro Glu
    850                 855                 860                 
Phe Tyr Leu Ser Val Ala Ile Asn Ser Tyr Ser Ala Leu Lys Asn Tyr
865                 870                 875                 880 
Phe Gly Pro Val His Ser Met Glu Glu Leu Pro Gly Tyr Glu Glu Thr
                885                 890                 895     
Leu Thr Arg Leu Ala Ala Ile Leu Ala Lys His Phe Ala Asp Ala Arg
            900                 905                 910         
Ile Val Gly Thr Asp Ile Arg Asp Ser Leu Met Gln Ala Leu Ala Ser
        915                 920                 925             
Tyr Val Cys Tyr Pro His Ser Leu Arg Ala Val Glu Arg Ile Pro Glu
    930                 935                 940                 
Glu Gln Arg Ile Ala Met Val Arg Asn Leu Leu Ala Pro Tyr Glu Gln
945                 950                 955                 960 
Arg Pro Trp Ala Gln Thr Asn Trp Ile Leu Val Arg Leu Trp Arg Gly
                965                 970                 975     
Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu Leu Lys Thr
            980                 985                 990         
Lys Leu Glu Asp Ala Asn Leu Pro Ser Leu Gln Lys Pro Cys Pro Ser
        995                 1000                1005            
Thr Leu Leu Gln Gln His Met Ala Asp Leu Leu Gln Gln Gly Pro Asp
    1010                1015                1020                
Val Ala Pro Ser Phe Leu Asn Ser Val Leu Asn Gln Leu Asn Trp Ala
1025                1030                1035                1040
Phe Ser Glu Phe Ile Gly Met Ile Gln Glu Ile Gln Gln Ala Ala Glu
                1045                1050                1055    
Arg Leu Glu Arg Asn Phe Val Asp Ser Arg Gln Leu Lys Val Cys Ala
            1060                1065                1070        
Thr Cys Phe Asp Leu Ser Val Ser Leu Leu Arg Val Leu Glu Met Thr
        1075                1080                1085            
Ile Thr Leu Val Pro Glu Ile Phe Leu Asp Trp Thr Arg Pro Thr Ser
    1090                1095                1100                
Glu Met Leu Leu Arg Arg Leu Ala Gln Leu Leu Asn Gln Val Leu Asn
1105                1110                1115                1120
Arg Val Thr Ala Glu Arg Asn Leu Phe Asp Arg Val Val Thr Leu Arg
                1125                1130                1135    
Leu Pro Gly Leu Glu Ser Val Asp His Tyr Pro Ile Leu Val Ala Val
            1140                1145                1150        
Thr Gly Ile Leu Val Gln Leu Leu Val Arg Gly Pro Ala Ser Glu Arg
        1155                1160                1165            
Glu Gln Ala Thr Ser Val Leu Leu Ala Asp Pro Cys Phe Gln Leu Arg
    1170                1175                1180                
Ser Ile Cys Tyr Leu Leu Gly Gln Pro Glu Pro Pro Ala Pro Gly Thr
1185                1190                1195                1200
Ala Leu Pro Ala Pro Asp Arg Lys Arg Phe Ser Leu Gln Ser Tyr Ala
                1205                1210                1215    
Asp Tyr Ile Ser Ala Asp Glu Leu Ala Gln Val Glu Gln Met Leu Ala
            1220                1225                1230        
His Leu Thr Ser Ala Ser Ala Gln Ala Ala Ala Ala Ser Leu Pro Thr
        1235                1240                1245            
Ser Glu Glu Asp Leu Cys Pro Ile Cys Tyr Ala His Pro Ile Ser Ala
    1250                1255                1260                
Val Phe Gln Pro Cys Gly His Lys Ser Cys Lys Ala Cys Ile Asn Gln
1265                1270                1275                1280
His Leu Met Asn Asn Lys Asp Cys Phe Phe Cys Lys Thr Thr Ile Val
                1285                1290                1295    
Ser Val Glu Asp Trp Glu Lys Gly Ala Asn Thr Ser Thr Thr Ser Ser
            1300                1305                1310        
Ala Ala
        


<210> 6150
<211> 905
<212> PRT
<213> Homo sapiens

<400> 6150
Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser
 1               5                  10                  15      
Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val
            20                  25                  30          
Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly
        35                  40                  45              
Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val
    50                  55                  60                  
Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys
65                  70                  75                  80  
Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val
                85                  90                  95      
Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp
            100                 105                 110         
Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg
        115                 120                 125             
Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala
    130                 135                 140                 
Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu
145                 150                 155                 160 
Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe
                165                 170                 175     
Lys Glu Phe Gly Lys Glu Met Val Lys Leu Asn Tyr Val Ala Ala Arg
            180                 185                 190         
Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala
        195                 200                 205             
Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser
    210                 215                 220                 
Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg
225                 230                 235                 240 
Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn
                245                 250                 255     
Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly
            260                 265                 270         
Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile
        275                 280                 285             
Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu
    290                 295                 300                 
Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp Ser
305                 310                 315                 320 
Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys Asn
                325                 330                 335     
Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn Asn
            340                 345                 350         
Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp Lys
        355                 360                 365             
Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val
    370                 375                 380                 
Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu
385                 390                 395                 400 
Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys Glu
                405                 410                 415     
Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val Ala
            420                 425                 430         
Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val
        435                 440                 445             
Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile Asn
    450                 455                 460                 
Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln Asp
465                 470                 475                 480 
Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val Leu
                485                 490                 495     
Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser Val
            500                 505                 510         
Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu
        515                 520                 525             
Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile Arg
    530                 535                 540                 
Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu Asn
545                 550                 555                 560 
Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu
                565                 570                 575     
Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val Ala
            580                 585                 590         
Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn Glu
        595                 600                 605             
Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile Arg
    610                 615                 620                 
Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp Ser
625                 630                 635                 640 
Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val Gln
                645                 650                 655     
Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met
            660                 665                 670         
Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val Glu
        675                 680                 685             
Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys Trp
    690                 695                 700                 
Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met
705                 710                 715                 720 
Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys
                725                 730                 735     
Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala Gly
            740                 745                 750         
Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro Asp
        755                 760                 765             
Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu
    770                 775                 780                 
Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln
785                 790                 795                 800 
Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Leu Asp Ser Ala Thr Ser
                805                 810                 815     
Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr Val
            820                 825                 830         
Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly Thr
        835                 840                 845             
Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro Glu
    850                 855                 860                 
Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr Arg
865                 870                 875                 880 
Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala Leu
                885                 890                 895     
Ser Glu Phe Lys Ala Met Asp Ser Phe
            900                 905 


<210> 6151
<211> 953
<212> PRT
<213> Homo sapiens

<400> 6151
Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser
 1               5                  10                  15      
Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val
            20                  25                  30          
Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly
        35                  40                  45              
Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val
    50                  55                  60                  
Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys
65                  70                  75                  80  
Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val
                85                  90                  95      
Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp
            100                 105                 110         
Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg
        115                 120                 125             
Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala
    130                 135                 140                 
Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu
145                 150                 155                 160 
Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe
                165                 170                 175     
Lys Glu Phe Gly Lys Lys Met Val Lys Leu Asn Tyr Val Ala Ala Arg
            180                 185                 190         
Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala
        195                 200                 205             
Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser
    210                 215                 220                 
Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg
225                 230                 235                 240 
Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn
                245                 250                 255     
Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly
            260                 265                 270         
Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile
        275                 280                 285             
Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu
    290                 295                 300                 
Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp Ser
305                 310                 315                 320 
Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys Asn
                325                 330                 335     
Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn Asn
            340                 345                 350         
Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp Lys
        355                 360                 365             
Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val
    370                 375                 380                 
Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu
385                 390                 395                 400 
Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys Glu
                405                 410                 415     
Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val Ala
            420                 425                 430         
Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val
        435                 440                 445             
Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile Asn
    450                 455                 460                 
Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln Asp
465                 470                 475                 480 
Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val Leu
                485                 490                 495     
Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser Val
            500                 505                 510         
Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu
        515                 520                 525             
Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile Arg
    530                 535                 540                 
Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu Asn
545                 550                 555                 560 
Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu
                565                 570                 575     
Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val Ala
            580                 585                 590         
Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn Glu
        595                 600                 605             
Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile Arg
    610                 615                 620                 
Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp Ser
625                 630                 635                 640 
Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Arg Gly Thr Ser Val Gln
                645                 650                 655     
Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met
            660                 665                 670         
Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val Glu
        675                 680                 685             
Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys Trp
    690                 695                 700                 
Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met
705                 710                 715                 720 
Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys
                725                 730                 735     
Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala Gly
            740                 745                 750         
Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro Asp
        755                 760                 765             
Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu
    770                 775                 780                 
Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln
785                 790                 795                 800 
Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Thr Gly Val Gln Ser Thr
                805                 810                 815     
Phe Thr Thr Phe Tyr Glu Val Asp Cys Asp Val Ile Asp Gly Gly Arg
            820                 825                 830         
Ala Ser Gln Leu Ser Thr His Leu Pro Thr Cys Ala Glu Gly Ala Pro
        835                 840                 845             
Ile Gly Ser Gly Ser Ser Asp Ser Ser Met Leu Asp Ser Ala Thr Ser
    850                 855                 860                 
Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr Val
865                 870                 875                 880 
Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly Thr
                885                 890                 895     
Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro Glu
            900                 905                 910         
Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr Arg
        915                 920                 925             
Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala Leu
    930                 935                 940                 
Ser Glu Phe Lys Ala Met Asp Ser Phe
945                 950             


<210> 6152
<211> 531
<212> PRT
<213> Homo sapiens

<400> 6152
Met Ser Ser Glu Met Glu Pro Leu Leu Leu Ala Trp Ser Tyr Phe Arg
 1               5                  10                  15      
Arg Arg Lys Phe Gln Leu Cys Ala Asp Leu Cys Thr Gln Met Leu Glu
            20                  25                  30          
Lys Ser Pro Tyr Asp Gln Ala Ala Trp Ile Leu Lys Ala Arg Ala Leu
        35                  40                  45              
Thr Glu Met Val Tyr Ile Asp Glu Ile Asp Val Asp Gln Glu Gly Ile
    50                  55                  60                  
Ala Glu Met Met Leu Asp Glu Asn Ala Ile Ala Gln Val Pro Arg Pro
65                  70                  75                  80  
Gly Thr Ser Leu Lys Leu Pro Gly Thr Asn Gln Thr Gly Gly Pro Ser
                85                  90                  95      
Gln Ala Val Arg Pro Ile Thr Gln Ala Gly Arg Pro Ile Thr Gly Phe
            100                 105                 110         
Leu Arg Pro Ser Thr Gln Ser Gly Arg Pro Gly Thr Met Glu Gln Ala
        115                 120                 125             
Ile Arg Thr Pro Arg Thr Ala Tyr Thr Ala Arg Pro Ile Thr Ser Ser
    130                 135                 140                 
Ser Gly Arg Phe Val Arg Leu Gly Thr Ala Ser Met Leu Thr Ser Pro
145                 150                 155                 160 
Asp Gly Pro Phe Ile Asn Leu Ser Arg Leu Asn Leu Thr Lys Tyr Ser
                165                 170                 175     
Gln Lys Pro Lys Leu Ala Lys Ala Leu Phe Glu Tyr Ile Phe His His
            180                 185                 190         
Glu Asn Asp Val Lys Thr Ile His Leu Glu Asp Val Val Leu His Leu
        195                 200                 205             
Gly Ile Tyr Pro Phe Leu Leu Arg Asn Lys Asn His Ile Glu Lys Asn
    210                 215                 220                 
Ala Leu Asp Leu Ala Ala Leu Ser Thr Glu His Ser Gln Tyr Lys Asp
225                 230                 235                 240 
Trp Trp Trp Lys Val Gln Ile Gly Lys Cys Tyr Tyr Arg Leu Gly Met
                245                 250                 255     
Tyr Arg Glu Ala Glu Lys Gln Phe Lys Ser Ala Leu Lys Gln Gln Glu
            260                 265                 270         
Met Val Asp Thr Phe Leu Tyr Leu Ala Lys Val Tyr Val Ser Leu Asp
        275                 280                 285             
Gln Pro Val Thr Ala Leu Asn Leu Phe Lys Gln Gly Leu Asp Lys Phe
    290                 295                 300                 
Pro Gly Glu Val Thr Leu Leu Cys Gly Ile Ala Arg Ile Tyr Glu Glu
305                 310                 315                 320 
Met Asn Asn Met Ser Ser Ala Ala Glu Tyr Tyr Lys Glu Val Leu Lys
                325                 330                 335     
Gln Asp Asn Thr His Val Glu Ala Ile Ala Cys Ile Gly Ser Asn His
            340                 345                 350         
Phe Tyr Ser Asp Gln Pro Glu Ile Ala Leu Arg Phe Tyr Arg Arg Leu
        355                 360                 365             
Leu Gln Met Gly Ile Tyr Asn Gly Gln Leu Phe Asn Asn Leu Gly Leu
    370                 375                 380                 
Cys Cys Phe Tyr Ala Gln Gln Tyr Asp Met Thr Leu Thr Ser Phe Glu
385                 390                 395                 400 
Arg Ala Leu Ser Leu Ala Glu Asn Glu Glu Glu Ala Ala Asp Val Trp
                405                 410                 415     
Tyr Asn Leu Gly His Val Ala Val Gly Ile Gly Asp Thr Asn Leu Ala
            420                 425                 430         
His Gln Cys Phe Arg Leu Ala Leu Val Asn Asn Asn Asn His Ala Glu
        435                 440                 445             
Ala Tyr Asn Asn Leu Ala Val Leu Glu Met Arg Lys Gly His Val Glu
    450                 455                 460                 
Gln Ala Arg Ala Leu Leu Gln Thr Ala Ser Ser Leu Ala Pro His Met
465                 470                 475                 480 
Tyr Glu Pro His Phe Asn Phe Ala Thr Ile Ser Asp Lys Ile Gly Asp
                485                 490                 495     
Leu Gln Arg Ser Tyr Val Ala Ala Gln Lys Ser Glu Ala Ala Phe Pro
            500                 505                 510         
Asp His Val Asp Thr Gln His Leu Ile Lys Gln Leu Arg Gln His Phe
        515                 520                 525             
Ala Met Leu
    530     


<210> 6153
<211> 505
<212> PRT
<213> Homo sapiens

<400> 6153
Met Ser Ser Glu Met Glu Pro Leu Leu Leu Ala Trp Ser Tyr Phe Arg
 1               5                  10                  15      
Arg Arg Lys Phe Gln Leu Cys Ala Asp Leu Cys Thr Gln Met Leu Glu
            20                  25                  30          
Lys Ser Pro Tyr Asp Gln Ala Ala Trp Ile Leu Lys Ala Arg Ala Leu
        35                  40                  45              
Thr Glu Met Val Tyr Ile Asp Glu Ile Asp Val Asp Gln Glu Gly Ile
    50                  55                  60                  
Ala Glu Met Met Leu Asp Glu Asn Ala Ile Ala Gln Val Pro Arg Pro
65                  70                  75                  80  
Gly Thr Ser Leu Lys Leu Pro Gly Thr Asn Gln Thr Gly Gly Pro Ser
                85                  90                  95      
Gln Ala Val Arg Pro Ile Thr Gln Ala Gly Arg Pro Ile Thr Gly Phe
            100                 105                 110         
Leu Arg Pro Ser Thr Gln Ser Gly Arg Pro Gly Thr Met Glu Gln Ala
        115                 120                 125             
Ile Arg Thr Pro Arg Thr Ala Tyr Thr Ala Arg Pro Ile Thr Ser Ser
    130                 135                 140                 
Ser Gly Arg Phe Val Arg Leu Gly Thr Ala Ser Met Leu Thr Ser Pro
145                 150                 155                 160 
Asp Gly Pro Phe Ile Asn Leu Ser Arg Leu Asn Leu Thr Lys Tyr Ser
                165                 170                 175     
Gln Lys Pro Lys Leu Ala Lys Ala Leu Phe Glu Tyr Ile Phe His His
            180                 185                 190         
Glu Asn Asp Val Lys Thr Ala Leu Asp Leu Ala Ala Leu Ser Thr Glu
        195                 200                 205             
His Ser Gln Tyr Lys Asp Trp Trp Trp Lys Val Gln Ile Gly Lys Cys
    210                 215                 220                 
Tyr Tyr Arg Leu Gly Met Tyr Arg Glu Ala Glu Lys Gln Phe Lys Ser
225                 230                 235                 240 
Ala Leu Lys Gln Gln Glu Met Val Asp Thr Phe Leu Tyr Leu Ala Lys
                245                 250                 255     
Val Tyr Val Ser Leu Asp Gln Pro Val Thr Ala Leu Asn Leu Phe Lys
            260                 265                 270         
Gln Gly Leu Asp Lys Phe Pro Gly Glu Val Thr Leu Leu Cys Gly Ile
        275                 280                 285             
Ala Arg Ile Tyr Glu Glu Met Asn Asn Met Ser Ser Ala Ala Glu Tyr
    290                 295                 300                 
Tyr Lys Glu Val Leu Lys Gln Asp Asn Thr His Val Glu Ala Ile Ala
305                 310                 315                 320 
Cys Ile Gly Ser Asn His Phe Tyr Ser Asp Gln Pro Glu Ile Ala Leu
                325                 330                 335     
Arg Phe Tyr Arg Arg Leu Leu Gln Met Gly Ile Tyr Asn Gly Gln Leu
            340                 345                 350         
Phe Asn Asn Leu Gly Leu Cys Cys Phe Tyr Ala Gln Gln Tyr Asp Met
        355                 360                 365             
Thr Leu Thr Ser Phe Glu Arg Ala Leu Ser Leu Ala Glu Asn Glu Glu
    370                 375                 380                 
Glu Ala Ala Asp Val Trp Tyr Asn Leu Gly His Val Ala Val Gly Ile
385                 390                 395                 400 
Gly Asp Thr Asn Leu Ala His Gln Cys Phe Arg Leu Ala Leu Val Asn
                405                 410                 415     
Asn Asn Asn His Ala Glu Ala Tyr Asn Asn Leu Ala Val Leu Glu Met
            420                 425                 430         
Arg Lys Gly His Val Glu Gln Ala Arg Ala Leu Leu Gln Thr Ala Ser
        435                 440                 445             
Ser Leu Ala Pro His Met Tyr Glu Pro His Phe Asn Phe Ala Thr Ile
    450                 455                 460                 
Ser Asp Lys Ile Gly Asp Leu Gln Arg Ser Tyr Val Ala Ala Gln Lys
465                 470                 475                 480 
Ser Glu Ala Ala Phe Pro Asp His Val Asp Thr Gln His Leu Ile Lys
                485                 490                 495     
Gln Leu Arg Gln His Phe Ala Met Leu
            500                 505 


<210> 6154
<211> 800
<212> PRT
<213> Homo sapiens

<400> 6154
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu
 1               5                  10                  15      
Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg
            20                  25                  30          
Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu
        35                  40                  45              
Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn
    50                  55                  60                  
Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile
65                  70                  75                  80  
Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser
                85                  90                  95      
Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr
            100                 105                 110         
Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys
        115                 120                 125             
Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp
    130                 135                 140                 
Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His
145                 150                 155                 160 
Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu
                165                 170                 175     
Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr
            180                 185                 190         
Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly
        195                 200                 205             
Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg
    210                 215                 220                 
Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His
225                 230                 235                 240 
Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile
                245                 250                 255     
Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys
            260                 265                 270         
Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu
        275                 280                 285             
Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys
    290                 295                 300                 
Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln
305                 310                 315                 320 
Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile
                325                 330                 335     
Gly Ala Trp Thr Glu Asp Asp Val Tyr Cys Trp Val Gln Gln Leu Val
            340                 345                 350         
Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe
        355                 360                 365             
Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu
    370                 375                 380                 
Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe
385                 390                 395                 400 
Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His
                405                 410                 415     
Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu
            420                 425                 430         
Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro
        435                 440                 445             
Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp
    450                 455                 460                 
Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr
465                 470                 475                 480 
Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val
                485                 490                 495     
Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys
            500                 505                 510         
Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His
        515                 520                 525             
Val His Leu Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys
    530                 535                 540                 
Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn
545                 550                 555                 560 
Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr
                565                 570                 575     
Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln
            580                 585                 590         
Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln
        595                 600                 605             
Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr
    610                 615                 620                 
Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln
625                 630                 635                 640 
Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp
                645                 650                 655     
Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg
            660                 665                 670         
Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu
        675                 680                 685             
Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr
    690                 695                 700                 
Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser
705                 710                 715                 720 
Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp
                725                 730                 735     
Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr
            740                 745                 750         
Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp
        755                 760                 765             
Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys
    770                 775                 780                 
Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe
785                 790                 795                 800 


<210> 6155
<211> 455
<212> PRT
<213> Homo sapiens

<400> 6155
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu
 1               5                  10                  15      
Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg
            20                  25                  30          
Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu
        35                  40                  45              
Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn
    50                  55                  60                  
Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile
65                  70                  75                  80  
Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser
                85                  90                  95      
Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr
            100                 105                 110         
Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys
        115                 120                 125             
Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp
    130                 135                 140                 
Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His
145                 150                 155                 160 
Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu
                165                 170                 175     
Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr
            180                 185                 190         
Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly
        195                 200                 205             
Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg
    210                 215                 220                 
Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His
225                 230                 235                 240 
Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile
                245                 250                 255     
Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys
            260                 265                 270         
Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu
        275                 280                 285             
Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys
    290                 295                 300                 
Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln
305                 310                 315                 320 
Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Leu Pro Leu Ala Ala
                325                 330                 335     
Arg Met Ser Glu Glu Ser Tyr Phe Glu Ser Lys Thr Glu Glu Ser Asn
            340                 345                 350         
Ser Ala Glu Met Ser Cys Gln Ile Thr Ala Thr Ser Asn Gly Glu Gly
        355                 360                 365             
His Gly Met Asn Pro Ser Leu Gln Ala Met Met Leu Met Gly Phe Gly
    370                 375                 380                 
Asp Ile Phe Ser Met Asn Lys Ala Gly Ala Val Met His Ser Gly Met
385                 390                 395                 400 
Gln Ile Asn Met Gln Ala Lys Gln Asn Ser Ser Lys Thr Thr Ser Lys
                405                 410                 415     
Arg Arg Gly Lys Lys Val Asn Met Ala Leu Gly Phe Ser Asp Phe Asp
            420                 425                 430         
Leu Ser Glu Gly Asp Asp Asp Asp Asp Asp Asp Gly Glu Glu Glu Asp
        435                 440                 445             
Asn Asp Met Asp Asn Ser Glu
    450                 455 


<210> 6156
<211> 800
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 346
<223> Xaa = Any Amino Acid

<400> 6156
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu
 1               5                  10                  15      
Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg
            20                  25                  30          
Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu
        35                  40                  45              
Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn
    50                  55                  60                  
Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile
65                  70                  75                  80  
Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser
                85                  90                  95      
Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr
            100                 105                 110         
Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys
        115                 120                 125             
Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp
    130                 135                 140                 
Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His
145                 150                 155                 160 
Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu
                165                 170                 175     
Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr
            180                 185                 190         
Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly
        195                 200                 205             
Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg
    210                 215                 220                 
Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His
225                 230                 235                 240 
Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile
                245                 250                 255     
Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys
            260                 265                 270         
Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu
        275                 280                 285             
Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys
    290                 295                 300                 
Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln
305                 310                 315                 320 
Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile
                325                 330                 335     
Gly Ala Trp Thr Glu Asp Asp Val Tyr Xaa Trp Val Gln Gln Leu Val
            340                 345                 350         
Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe
        355                 360                 365             
Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu
    370                 375                 380                 
Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe
385                 390                 395                 400 
Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His
                405                 410                 415     
Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu
            420                 425                 430         
Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro
        435                 440                 445             
Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp
    450                 455                 460                 
Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr
465                 470                 475                 480 
Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val
                485                 490                 495     
Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys
            500                 505                 510         
Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His
        515                 520                 525             
Val His Leu Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys
    530                 535                 540                 
Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn
545                 550                 555                 560 
Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr
                565                 570                 575     
Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln
            580                 585                 590         
Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln
        595                 600                 605             
Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr
    610                 615                 620                 
Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln
625                 630                 635                 640 
Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp
                645                 650                 655     
Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg
            660                 665                 670         
Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu
        675                 680                 685             
Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr
    690                 695                 700                 
Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser
705                 710                 715                 720 
Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp
                725                 730                 735     
Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr
            740                 745                 750         
Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp
        755                 760                 765             
Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys
    770                 775                 780                 
Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe
785                 790                 795                 800 


<210> 6157
<211> 312
<212> PRT
<213> Homo sapiens

<400> 6157
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu
 1               5                  10                  15      
Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg
            20                  25                  30          
Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu
        35                  40                  45              
Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn
    50                  55                  60                  
Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile
65                  70                  75                  80  
Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser
                85                  90                  95      
Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr
            100                 105                 110         
Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys
        115                 120                 125             
Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp
    130                 135                 140                 
Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His
145                 150                 155                 160 
Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu
                165                 170                 175     
Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr
            180                 185                 190         
Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly
        195                 200                 205             
Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg
    210                 215                 220                 
Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His
225                 230                 235                 240 
Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile
                245                 250                 255     
Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys
            260                 265                 270         
Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Trp Val Ala Pro
        275                 280                 285             
Thr Ala Gly His Ser Val Trp Leu Ser Lys Thr Ile Thr Arg Leu Asn
    290                 295                 300                 
Glu Glu Val Asn Gln Arg Ser Glu
305                 310         


<210> 6158
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6158
Met Tyr Thr Ala Ile Pro Gln Ser Gly Ser Pro Phe Pro Gly Ser Val
 1               5                  10                  15      
Gln Asp Pro Gly Leu His Val Trp Arg Val Glu Lys Leu Lys Pro Val
            20                  25                  30          
Pro Val Ala Gln Glu Asn Gln Gly Val Phe Phe Ser Gly Asp Ser Tyr
        35                  40                  45              
Leu Val Leu His Asn Gly Pro Glu Glu Val Ser His Leu His Leu Trp
    50                  55                  60                  
Ile Gly Gln Gln Ser Ser Arg Asp Glu Gln Gly Ala Cys Ala Val Leu
65                  70                  75                  80  
Ala Val His Leu Asn Thr Leu Leu Gly Glu Arg Pro Val Gln His Arg
                85                  90                  95      
Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro Arg
            100                 105                 110         
Gly Leu Lys Tyr Gln Glu Gly Gly Val Glu Ser Ala Phe His Lys Thr
        115                 120                 125             
Ser Thr Gly Ala Pro Ala Ala Ile Lys Lys Leu Tyr Gln Val Lys Gly
    130                 135                 140                 
Lys Lys Asn Ile Arg Ala Thr Glu Arg Ala Leu Asn Trp Asp Ser Phe
145                 150                 155                 160 
Asn Thr Gly Asp Cys Phe Ile Leu Asp Leu Gly Gln Asn Ile Phe Ala
                165                 170                 175     
Trp Cys Gly Gly Lys Ser Asn Ile Leu Glu Arg Asn Lys Ala Arg Asp
            180                 185                 190         
Leu Ala Leu Ala Ile Arg Asp Ser Glu Arg Gln Gly Lys Ala Gln Val
        195                 200                 205             
Glu Ile Val Thr Asp Gly Glu Glu Pro Ala Glu Met Ile Gln Val Leu
    210                 215                 220                 
Gly Pro Lys Pro Ala Leu Lys Glu Gly Asn Pro Glu Glu Asp Leu Thr
225                 230                 235                 240 
Ala Asp Lys Ala Asn Ala Gln Ala Ala Ala Leu Tyr Lys Val Ser Asp
                245                 250                 255     
Ala Thr Gly Gln Met Asn Leu Thr Lys Val Ala Asp Ser Ser Pro Phe
            260                 265                 270         
Ala Leu Glu Leu Leu Ile Ser Asp Asp Cys Phe Val Leu Asp Asn Gly
        275                 280                 285             
Leu Cys Gly Lys Ile Tyr Ile Trp Lys Gly Arg Lys Ala Asn Glu Lys
    290                 295                 300                 
Glu Arg Gln Ala Ala Leu Gln Val Ala Glu Gly Phe Ile Ser Arg Met
305                 310                 315                 320 
Gln Tyr Ala Pro Asn Thr Gln Val Glu Ile Leu Pro Gln Gly Arg Glu
                325                 330                 335     
Ser Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Lys
            340                 345             


<210> 6159
<211> 374
<212> PRT
<213> Homo sapiens

<400> 6159
Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg
 1               5                  10                  15      
Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu
            20                  25                  30          
Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val His Lys Lys Cys
        35                  40                  45              
Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu
    50                  55                  60                  
Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg
65                  70                  75                  80  
Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met
                85                  90                  95      
Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu
            100                 105                 110         
Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser
        115                 120                 125             
Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile
    130                 135                 140                 
Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly
145                 150                 155                 160 
Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys
                165                 170                 175     
Leu Pro Thr Glu Val Leu Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln
            180                 185                 190         
Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly
        195                 200                 205             
Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp
    210                 215                 220                 
Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro
225                 230                 235                 240 
Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr
                245                 250                 255     
Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp
            260                 265                 270         
Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu
        275                 280                 285             
Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser
    290                 295                 300                 
Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe
305                 310                 315                 320 
Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr
                325                 330                 335     
Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His
            340                 345                 350         
Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Asp Gly
        355                 360                 365             
Ala Phe Gly Gly Cys Val
    370                 


<210> 6160
<211> 570
<212> PRT
<213> Homo sapiens

<400> 6160
Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg
 1               5                  10                  15      
Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu
            20                  25                  30          
Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val His Lys Lys Cys
        35                  40                  45              
Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu
    50                  55                  60                  
Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg
65                  70                  75                  80  
Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met
                85                  90                  95      
Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu
            100                 105                 110         
Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser
        115                 120                 125             
Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile
    130                 135                 140                 
Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly
145                 150                 155                 160 
Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys
                165                 170                 175     
Leu Pro Thr Glu Val Leu Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln
            180                 185                 190         
Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly
        195                 200                 205             
Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp
    210                 215                 220                 
Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro
225                 230                 235                 240 
Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr
                245                 250                 255     
Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp
            260                 265                 270         
Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu
        275                 280                 285             
Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser
    290                 295                 300                 
Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe
305                 310                 315                 320 
Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr
                325                 330                 335     
Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His
            340                 345                 350         
Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro
        355                 360                 365             
Lys Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro
    370                 375                 380                 
Ala Phe Leu Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp
385                 390                 395                 400 
Arg Leu Ala Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu
                405                 410                 415     
Arg Asn Asn Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu
            420                 425                 430         
Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser
        435                 440                 445             
Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe
    450                 455                 460                 
Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu
465                 470                 475                 480 
Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu
                485                 490                 495     
His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro
            500                 505                 510         
Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu
        515                 520                 525             
Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val
    530                 535                 540                 
Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Glu Glu Glu Leu Lys Gln
545                 550                 555                 560 
Gly Val Ser Tyr Val Pro Tyr Cys Arg Ser
                565                 570 


<210> 6161
<211> 686
<212> PRT
<213> Homo sapiens

<400> 6161
Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg
 1               5                  10                  15      
Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu
            20                  25                  30          
Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val His Lys Lys Cys
        35                  40                  45              
Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu
    50                  55                  60                  
Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg
65                  70                  75                  80  
Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met
                85                  90                  95      
Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu
            100                 105                 110         
Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser
        115                 120                 125             
Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile
    130                 135                 140                 
Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly
145                 150                 155                 160 
Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys
                165                 170                 175     
Leu Pro Thr Glu Val Leu Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln
            180                 185                 190         
Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly
        195                 200                 205             
Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp
    210                 215                 220                 
Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro
225                 230                 235                 240 
Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr
                245                 250                 255     
Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp
            260                 265                 270         
Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu
        275                 280                 285             
Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser
    290                 295                 300                 
Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe
305                 310                 315                 320 
Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr
                325                 330                 335     
Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His
            340                 345                 350         
Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Met Leu Glu
        355                 360                 365             
Ser Ser Asn Arg Leu Asp Glu Glu His Arg Leu Ile Ala Arg Tyr Ala
    370                 375                 380                 
Ala Arg Leu Ala Ala Glu Ser Ser Ser Ser Gln Pro Pro Gln Gln Arg
385                 390                 395                 400 
Ser Ala Pro Asp Ile Ser Phe Thr Ile Asp Ala Asn Lys Gln Gln Arg
                405                 410                 415     
Gln Leu Ile Ala Glu Leu Glu Asn Lys Asn Arg Glu Ile Leu Gln Glu
            420                 425                 430         
Ile Gln Arg Leu Arg Leu Glu His Glu Gln Ala Ser Gln Pro Thr Pro
        435                 440                 445             
Glu Lys Ala Gln Gln Asn Pro Thr Leu Leu Ala Glu Leu Arg Leu Leu
    450                 455                 460                 
Arg Gln Arg Lys Asp Glu Leu Glu Gln Arg Met Ser Ala Leu Gln Glu
465                 470                 475                 480 
Ser Arg Arg Glu Leu Met Val Gln Leu Glu Gly Leu Met Lys Leu Leu
                485                 490                 495     
Lys Thr Gln Gly Ala Gly Ser Pro Arg Ser Ser Pro Ser His Thr Ile
            500                 505                 510         
Ser Arg Pro Ile Pro Met Pro Ile Arg Ser Ala Ser Ala Cys Ser Thr
        515                 520                 525             
Pro Thr His Thr Pro Gln Asp Ser Leu Thr Gly Val Gly Gly Asp Val
    530                 535                 540                 
Gln Glu Ala Phe Ala Gln Ser Ser Arg Arg Asn Leu Arg Asn Asp Leu
545                 550                 555                 560 
Leu Val Ala Ala Asp Ser Ile Thr Asn Thr Met Ser Ser Leu Val Lys
                565                 570                 575     
Glu Leu Asn Ser Glu Val Gly Ser Glu Thr Glu Ser Asn Val Asp Ser
            580                 585                 590         
Glu Phe Ala Arg Thr Gln Phe Glu Asp Leu Val Pro Ser Pro Thr Ser
        595                 600                 605             
Glu Lys Ala Phe Leu Ala Gln Ile His Ala Arg Lys Pro Gly Tyr Ile
    610                 615                 620                 
His Ser Gly Ala Thr Thr Ser Thr Met Arg Gly Asp Met Val Thr Glu
625                 630                 635                 640 
Asp Ala Asp Pro Tyr Val Gln Pro Glu Asp Glu Asn Tyr Glu Asn Asp
                645                 650                 655     
Ser Val Arg Gln Leu Glu Asn Glu Leu Gln Met Glu Glu Tyr Leu Lys
            660                 665                 670         
Gln Lys Leu Gln Asp Glu Ala Tyr Gln Val Ser Leu Gln Gly
        675                 680                 685     


<210> 6162
<211> 513
<212> PRT
<213> Homo sapiens

<400> 6162
Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg
 1               5                  10                  15      
Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu
            20                  25                  30          
Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val His Lys Lys Cys
        35                  40                  45              
Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu
    50                  55                  60                  
Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg
65                  70                  75                  80  
Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met
                85                  90                  95      
Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu
            100                 105                 110         
Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser
        115                 120                 125             
Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile
    130                 135                 140                 
Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly
145                 150                 155                 160 
Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys
                165                 170                 175     
Leu Pro Thr Glu Val Leu Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln
            180                 185                 190         
Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly
        195                 200                 205             
Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp
    210                 215                 220                 
Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro
225                 230                 235                 240 
Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr
                245                 250                 255     
Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp
            260                 265                 270         
Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu
        275                 280                 285             
Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser
    290                 295                 300                 
Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe
305                 310                 315                 320 
Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr
                325                 330                 335     
Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His
            340                 345                 350         
Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Met Leu Glu
        355                 360                 365             
Ser Ser Asn Arg Leu Asp Glu Glu His Arg Leu Ile Ala Arg Tyr Ala
    370                 375                 380                 
Ala Arg Leu Ala Ala Glu Ser Ser Ser Ser Gln Pro Pro Gln Gln Arg
385                 390                 395                 400 
Ser Ala Pro Asp Ile Ser Phe Thr Ile Asp Ala Asn Lys Gln Gln Arg
                405                 410                 415     
Gln Leu Ile Ala Glu Leu Glu Asn Lys Asn Arg Glu Ile Leu Gln Glu
            420                 425                 430         
Ile Gln Arg Leu Arg Leu Glu His Glu Gln Ala Ser Gln Pro Thr Pro
        435                 440                 445             
Glu Lys Ala Gln Gln Asn Pro Thr Leu Leu Ala Glu Leu Arg Leu Leu
    450                 455                 460                 
Arg Gln Arg Lys Asp Glu Leu Glu Gln Arg Met Ser Ala Leu Gln Glu
465                 470                 475                 480 
Ser Arg Arg Glu Leu Met Val Gln Leu Glu Gly Leu Met Lys Leu Leu
                485                 490                 495     
Lys Glu Glu Glu Leu Lys Gln Gly Val Ser Tyr Val Pro Tyr Cys Arg
            500                 505                 510         
Ser
    


<210> 6163
<211> 743
<212> PRT
<213> Homo sapiens

<400> 6163
Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg
 1               5                  10                  15      
Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu
            20                  25                  30          
Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val His Lys Lys Cys
        35                  40                  45              
Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu
    50                  55                  60                  
Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg
65                  70                  75                  80  
Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met
                85                  90                  95      
Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu
            100                 105                 110         
Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser
        115                 120                 125             
Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile
    130                 135                 140                 
Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly
145                 150                 155                 160 
Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys
                165                 170                 175     
Leu Pro Thr Glu Val Leu Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln
            180                 185                 190         
Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly
        195                 200                 205             
Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp
    210                 215                 220                 
Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro
225                 230                 235                 240 
Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr
                245                 250                 255     
Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp
            260                 265                 270         
Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu
        275                 280                 285             
Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser
    290                 295                 300                 
Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe
305                 310                 315                 320 
Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr
                325                 330                 335     
Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His
            340                 345                 350         
Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro
        355                 360                 365             
Lys Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro
    370                 375                 380                 
Ala Phe Leu Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp
385                 390                 395                 400 
Arg Leu Ala Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu
                405                 410                 415     
Arg Asn Asn Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu
            420                 425                 430         
Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser
        435                 440                 445             
Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe
    450                 455                 460                 
Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu
465                 470                 475                 480 
Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu
                485                 490                 495     
His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro
            500                 505                 510         
Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu
        515                 520                 525             
Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val
    530                 535                 540                 
Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Thr Gln Gly Ala Gly Ser
545                 550                 555                 560 
Pro Arg Ser Ser Pro Ser His Thr Ile Ser Arg Pro Ile Pro Met Pro
                565                 570                 575     
Ile Arg Ser Ala Ser Ala Cys Ser Thr Pro Thr His Thr Pro Gln Asp
            580                 585                 590         
Ser Leu Thr Gly Val Gly Gly Asp Val Gln Glu Ala Phe Ala Gln Ser
        595                 600                 605             
Ser Arg Arg Asn Leu Arg Asn Asp Leu Leu Val Ala Ala Asp Ser Ile
    610                 615                 620                 
Thr Asn Thr Met Ser Ser Leu Val Lys Glu Leu Asn Ser Glu Val Gly
625                 630                 635                 640 
Ser Glu Thr Glu Ser Asn Val Asp Ser Glu Phe Ala Arg Thr Gln Phe
                645                 650                 655     
Glu Asp Leu Val Pro Ser Pro Thr Ser Glu Lys Ala Phe Leu Ala Gln
            660                 665                 670         
Ile His Ala Arg Lys Pro Gly Tyr Ile His Ser Gly Ala Thr Thr Ser
        675                 680                 685             
Thr Met Arg Gly Asp Met Val Thr Glu Asp Ala Asp Pro Tyr Val Gln
    690                 695                 700                 
Pro Glu Asp Glu Asn Tyr Glu Asn Asp Ser Val Arg Gln Leu Glu Asn
705                 710                 715                 720 
Glu Leu Gln Met Glu Glu Tyr Leu Lys Gln Lys Leu Gln Asp Glu Ala
                725                 730                 735     
Tyr Gln Val Ser Leu Gln Gly
            740             


<210> 6164
<211> 567
<212> PRT
<213> Homo sapiens

<400> 6164
Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg
 1               5                  10                  15      
Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu
            20                  25                  30          
Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val His Lys Lys Cys
        35                  40                  45              
Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu
    50                  55                  60                  
Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg
65                  70                  75                  80  
Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met
                85                  90                  95      
Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu
            100                 105                 110         
Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser
        115                 120                 125             
Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile
    130                 135                 140                 
Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly
145                 150                 155                 160 
Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys
                165                 170                 175     
Leu Pro Thr Glu Val Leu Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln
            180                 185                 190         
Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly
        195                 200                 205             
Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp
    210                 215                 220                 
Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro
225                 230                 235                 240 
Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr
                245                 250                 255     
Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp
            260                 265                 270         
Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu
        275                 280                 285             
Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser
    290                 295                 300                 
Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe
305                 310                 315                 320 
Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Pro Pro
                325                 330                 335     
Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His Ser Val Pro
            340                 345                 350         
Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro Lys Asp Ser
        355                 360                 365             
Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro Ala Phe Leu
    370                 375                 380                 
Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp Arg Leu Ala
385                 390                 395                 400 
Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu Arg Asn Asn
                405                 410                 415     
Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu Glu His Arg
            420                 425                 430         
Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser Ser Ser Ser
        435                 440                 445             
Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe Thr Ile Asp
    450                 455                 460                 
Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu Asn Lys Asn
465                 470                 475                 480 
Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu His Glu Gln
                485                 490                 495     
Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro Thr Leu Leu
            500                 505                 510         
Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu Glu Gln Arg
        515                 520                 525             
Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val Gln Leu Glu
    530                 535                 540                 
Gly Leu Met Lys Leu Leu Lys Glu Glu Glu Leu Lys Gln Gly Val Ser
545                 550                 555                 560 
Tyr Val Pro Tyr Cys Arg Ser
                565         


<210> 6165
<211> 640
<212> PRT
<213> Homo sapiens

<400> 6165
Met Asp Arg Arg Ile Glu Asn Arg Met Gly Thr Pro Ala His Arg Arg
 1               5                  10                  15      
Arg Val Val His Thr His Arg His Thr Arg Asn Arg Leu Ser Cys Pro
            20                  25                  30          
Trp Pro Pro Pro Phe Thr Ser Pro Thr Leu Thr Pro Gly Ile Leu Leu
        35                  40                  45              
Gly Thr Ile Thr Leu Ile Thr Glu Leu Cys Glu Arg Ser Pro Ala Ala
    50                  55                  60                  
Leu Arg His Phe Arg Lys Val Val Pro Gln Leu Val His Ile Leu Arg
65                  70                  75                  80  
Thr Leu Val Thr Met Gly Tyr Ser Thr Glu His Ser Ile Ser Gly Val
                85                  90                  95      
Ser Asp Pro Phe Leu Gln Val Gln Ile Leu Arg Leu Leu Arg Ile Leu
            100                 105                 110         
Gly Arg Asn His Glu Glu Ser Ser Glu Thr Met Asn Asp Leu Leu Ala
        115                 120                 125             
Gln Val Ala Thr Asn Thr Asp Thr Ser Arg Asn Ala Gly Asn Ala Val
    130                 135                 140                 
Leu Phe Glu Thr Val Leu Thr Ile Met Asp Ile Arg Ser Ala Ala Gly
145                 150                 155                 160 
Leu Arg Val Leu Ala Val Asn Ile Leu Gly Arg Phe Leu Leu Asn Ser
                165                 170                 175     
Asp Arg Asn Ile Arg Tyr Val Ala Leu Thr Ser Leu Leu Arg Leu Val
            180                 185                 190         
Gln Ser Asp His Ser Ala Val Gln Arg His Arg Pro Thr Val Val Glu
        195                 200                 205             
Cys Leu Arg Glu Thr Asp Ala Ser Leu Ser Arg Arg Ala Leu Glu Leu
    210                 215                 220                 
Ser Leu Ala Leu Val Asn Ser Ser Asn Val Arg Ala Met Met Gln Glu
225                 230                 235                 240 
Leu Gln Ala Phe Leu Glu Ser Cys Pro Pro Asp Leu Arg Ala Asp Cys
                245                 250                 255     
Ala Ser Gly Ile Leu Leu Ala Ala Glu Arg Phe Ala Pro Thr Lys Arg
            260                 265                 270         
Trp His Ile Asp Thr Ile Leu His Val Leu Thr Thr Ala Gly Thr His
        275                 280                 285             
Val Arg Asp Asp Ala Val Ala Asn Leu Thr Gln Leu Ile Gly Gly Ala
    290                 295                 300                 
Gln Glu Leu His Ala Tyr Ser Val Arg Arg Leu Tyr Asn Ala Leu Ala
305                 310                 315                 320 
Glu Asp Ile Ser Gln Gln Pro Leu Val Gln Val Ala Ala Trp Cys Ile
                325                 330                 335     
Gly Glu Tyr Gly Asp Leu Leu Leu Ala Gly Asn Cys Glu Glu Ile Glu
            340                 345                 350         
Pro Leu Gln Val Asp Glu Glu Glu Val Leu Ala Leu Leu Glu Lys Val
        355                 360                 365             
Leu Gln Ser His Met Ser Leu Pro Ala Thr Arg Gly Tyr Ala Leu Thr
    370                 375                 380                 
Ala Leu Met Lys Leu Ser Thr Arg Leu Cys Gly Asp Asn Asn Arg Ile
385                 390                 395                 400 
Arg Gln Val Val Ser Ile Tyr Gly Ser Cys Leu Asp Val Glu Leu Gln
                405                 410                 415     
Gln Arg Ala Val Glu Tyr Asp Thr Leu Phe Arg Lys Tyr Asp His Met
            420                 425                 430         
Arg Ala Ala Ile Leu Glu Lys Met Pro Leu Val Glu Arg Asp Gly Pro
        435                 440                 445             
Gln Ala Asp Glu Glu Ala Lys Glu Ser Lys Glu Ala Ala Gln Leu Ser
    450                 455                 460                 
Glu Ala Ala Pro Val Pro Thr Glu Pro Gln Ala Ser Gln Leu Leu Asp
465                 470                 475                 480 
Leu Leu Asp Leu Leu Asp Gly Ala Ser Gly Asp Val Gln His Pro Pro
                485                 490                 495     
His Leu Asp Pro Ser Pro Gly Gly Ala Leu Val His Leu Leu Asp Leu
            500                 505                 510         
Pro Cys Val Pro Pro Pro Pro Ala Pro Ile Pro Asp Leu Lys Val Phe
        515                 520                 525             
Glu Arg Glu Gly Val Gln Leu Asn Leu Ser Phe Ile Arg Pro Pro Glu
    530                 535                 540                 
Asn Pro Ala Leu Leu Leu Ile Thr Ile Thr Ala Thr Asn Phe Ser Glu
545                 550                 555                 560 
Gly Asp Val Thr His Phe Ile Cys Gln Ala Ala Val Pro Lys Ser Leu
                565                 570                 575     
Gln Leu Gln Leu Gln Ala Pro Ser Gly Asn Thr Val Pro Ala Arg Gly
            580                 585                 590         
Gly Leu Pro Ile Thr Gln Leu Phe Arg Ile Leu Asn Pro Asn Lys Ala
        595                 600                 605             
Pro Leu Arg Leu Lys Leu Arg Leu Thr Tyr Asp His Phe His Gln Ser
    610                 615                 620                 
Val Gln Glu Ile Phe Glu Val Asn Asn Leu Pro Val Glu Ser Trp Gln
625                 630                 635                 640 


<210> 6166
<211> 785
<212> PRT
<213> Homo sapiens

<400> 6166
Met Val Val Pro Ser Leu Lys Leu Gln Asp Leu Ile Glu Glu Ile Arg
 1               5                  10                  15      
Gly Ala Lys Thr Gln Ala Gln Glu Arg Glu Val Ile Gln Lys Glu Cys
            20                  25                  30          
Ala His Ile Arg Ala Ser Phe Arg Asp Gly Asp Pro Val His Arg His
        35                  40                  45              
Arg Gln Leu Ala Lys Leu Leu Tyr Val His Met Leu Gly Tyr Pro Ala
    50                  55                  60                  
His Phe Gly Gln Met Glu Cys Leu Lys Leu Ile Ala Ser Ser Arg Phe
65                  70                  75                  80  
Thr Asp Lys Arg Val Gly Tyr Leu Gly Ala Met Leu Leu Leu Asp Glu
                85                  90                  95      
Arg His Asp Ala His Leu Leu Ile Thr Asn Ser Ile Lys Asn Asp Leu
            100                 105                 110         
Ser Gln Gly Ile Gln Pro Val Gln Gly Leu Ala Leu Cys Thr Leu Ser
        115                 120                 125             
Thr Met Gly Ser Ala Glu Met Cys Arg Asp Leu Ala Pro Glu Val Glu
    130                 135                 140                 
Lys Leu Leu Leu Gln Pro Ser Pro Tyr Val Arg Lys Lys Ala Ile Leu
145                 150                 155                 160 
Thr Ala Val His Met Ile Arg Lys Val Pro Glu Leu Ser Ser Val Phe
                165                 170                 175     
Leu Pro Pro Cys Ala Gln Leu Leu His Glu Arg His His Gly Ile Leu
            180                 185                 190         
Leu Gly Thr Ile Thr Leu Ile Thr Glu Leu Cys Glu Arg Ser Pro Ala
        195                 200                 205             
Ala Leu Arg His Phe Arg Lys Val Val Pro Gln Leu Val His Ile Leu
    210                 215                 220                 
Arg Thr Leu Val Thr Met Gly Tyr Ser Thr Glu His Ser Ile Ser Gly
225                 230                 235                 240 
Val Ser Asp Pro Phe Leu Gln Val Gln Ile Leu Arg Leu Leu Arg Ile
                245                 250                 255     
Leu Gly Arg Asn His Glu Glu Ser Ser Glu Thr Met Asn Asp Leu Leu
            260                 265                 270         
Ala Gln Val Ala Thr Asn Thr Asp Thr Ser Arg Asn Ala Gly Asn Ala
        275                 280                 285             
Val Leu Phe Glu Thr Val Leu Thr Ile Met Asp Ile Arg Ser Ala Ala
    290                 295                 300                 
Gly Leu Arg Val Leu Ala Val Asn Ile Leu Gly Arg Phe Leu Leu Asn
305                 310                 315                 320 
Ser Asp Arg Asn Ile Arg Tyr Val Ala Leu Thr Ser Leu Leu Arg Leu
                325                 330                 335     
Val Gln Ser Asp His Ser Ala Val Gln Arg His Arg Pro Thr Val Val
            340                 345                 350         
Glu Cys Leu Arg Glu Thr Asp Ala Ser Leu Ser Arg Arg Ala Leu Glu
        355                 360                 365             
Leu Ser Leu Ala Leu Val Asn Ser Ser Asn Val Arg Ala Met Met Gln
    370                 375                 380                 
Glu Leu Gln Ala Phe Leu Glu Ser Cys Pro Pro Asp Leu Arg Ala Asp
385                 390                 395                 400 
Cys Ala Ser Gly Ile Leu Leu Ala Ala Glu Arg Phe Ala Pro Thr Lys
                405                 410                 415     
Arg Trp His Ile Asp Thr Ile Leu His Val Leu Thr Thr Ala Gly Thr
            420                 425                 430         
His Val Arg Asp Asp Ala Val Ala Asn Leu Thr Gln Leu Ile Gly Gly
        435                 440                 445             
Ala Gln Glu Leu His Ala Tyr Ser Val Arg Arg Leu Tyr Asn Ala Leu
    450                 455                 460                 
Ala Glu Asp Ile Ser Gln Gln Pro Leu Val Gln Val Ala Ala Trp Cys
465                 470                 475                 480 
Ile Gly Glu Tyr Gly Asp Leu Leu Leu Ala Gly Asn Cys Glu Glu Ile
                485                 490                 495     
Glu Pro Leu Gln Val Asp Glu Glu Glu Val Leu Ala Leu Leu Glu Lys
            500                 505                 510         
Val Leu Gln Ser His Met Ser Leu Pro Ala Thr Arg Gly Tyr Ala Leu
        515                 520                 525             
Thr Ala Leu Met Lys Leu Ser Thr Arg Leu Cys Gly Asp Asn Asn Arg
    530                 535                 540                 
Ile Arg Gln Val Val Ser Ile Tyr Gly Ser Cys Leu Asp Val Glu Leu
545                 550                 555                 560 
Gln Gln Arg Ala Val Glu Tyr Asp Thr Leu Phe Arg Lys Tyr Asp His
                565                 570                 575     
Met Arg Ala Ala Ile Leu Glu Lys Met Pro Leu Val Glu Arg Asp Gly
            580                 585                 590         
Pro Gln Ala Asp Glu Glu Ala Lys Glu Ser Lys Glu Ala Ala Gln Leu
        595                 600                 605             
Ser Glu Ala Ala Pro Val Pro Thr Glu Pro Gln Ala Ser Gln Leu Leu
    610                 615                 620                 
Asp Leu Leu Asp Leu Leu Asp Gly Ala Ser Gly Asp Val Gln His Pro
625                 630                 635                 640 
Pro His Leu Asp Pro Ser Pro Gly Gly Ala Leu Val His Leu Leu Asp
                645                 650                 655     
Leu Pro Cys Val Pro Pro Pro Pro Ala Pro Ile Pro Asp Leu Lys Val
            660                 665                 670         
Phe Glu Arg Glu Gly Val Gln Leu Asn Leu Ser Phe Ile Arg Pro Pro
        675                 680                 685             
Glu Asn Pro Ala Leu Leu Leu Ile Thr Ile Thr Ala Thr Asn Phe Ser
    690                 695                 700                 
Glu Gly Asp Val Thr His Phe Ile Cys Gln Ala Ala Val Pro Lys Ser
705                 710                 715                 720 
Leu Gln Leu Gln Leu Gln Ala Pro Ser Gly Asn Thr Val Pro Ala Arg
                725                 730                 735     
Gly Gly Leu Pro Ile Thr Gln Leu Phe Arg Ile Leu Asn Pro Asn Lys
            740                 745                 750         
Ala Pro Leu Arg Leu Lys Leu Arg Leu Thr Tyr Asp His Phe His Gln
        755                 760                 765             
Ser Val Gln Glu Ile Phe Glu Val Asn Asn Leu Pro Val Glu Ser Trp
    770                 775                 780                 
Gln
785 


<210> 6167
<211> 2002
<212> PRT
<213> Homo sapiens

<400> 6167
Met Glu Gln Asp Arg Thr Asn His Val Glu Gly Asn Arg Leu Ser Pro
 1               5                  10                  15      
Phe Leu Ile Pro Ser Pro Pro Ile Cys Gln Thr Glu Pro Leu Ala Thr
            20                  25                  30          
Lys Leu Gln Asn Gly Ser Pro Leu Pro Glu Arg Ala His Pro Glu Val
        35                  40                  45              
Asn Gly Asp Thr Lys Trp His Ser Phe Lys Ser Tyr Tyr Gly Ile Pro
    50                  55                  60                  
Cys Met Lys Gly Ser Gln Asn Ser Arg Val Ser Pro Asp Phe Thr Gln
65                  70                  75                  80  
Glu Ser Arg Gly Tyr Ser Lys Cys Leu Gln Asn Gly Gly Ile Lys Arg
                85                  90                  95      
Thr Val Ser Glu Pro Ser Leu Ser Gly Leu Leu Gln Ile Lys Lys Leu
            100                 105                 110         
Lys Gln Asp Gln Lys Ala Asn Gly Glu Arg Arg Asn Phe Gly Val Ser
        115                 120                 125             
Gln Glu Arg Asn Pro Gly Glu Ser Ser Gln Pro Asn Val Ser Asp Leu
    130                 135                 140                 
Ser Asp Lys Lys Glu Ser Val Ser Ser Val Ala Gln Glu Asn Ala Val
145                 150                 155                 160 
Lys Asp Phe Thr Ser Phe Ser Thr His Asn Cys Ser Gly Pro Glu Asn
                165                 170                 175     
Pro Glu Leu Gln Ile Leu Asn Glu Gln Glu Gly Lys Ser Ala Asn Tyr
            180                 185                 190         
His Asp Lys Asn Ile Val Leu Leu Lys Asn Lys Ala Val Leu Met Pro
        195                 200                 205             
Asn Gly Ala Thr Val Ser Ala Ser Ser Val Glu His Thr His Gly Glu
    210                 215                 220                 
Leu Leu Glu Lys Thr Leu Ser Gln Tyr Tyr Pro Asp Cys Val Ser Ile
225                 230                 235                 240 
Ala Val Gln Lys Thr Thr Ser His Ile Asn Ala Ile Asn Ser Gln Ala
                245                 250                 255     
Thr Asn Glu Leu Ser Cys Glu Ile Thr His Pro Ser His Thr Ser Gly
            260                 265                 270         
Gln Ile Asn Ser Ala Gln Thr Ser Asn Ser Glu Leu Pro Pro Lys Pro
        275                 280                 285             
Ala Ala Val Val Ser Glu Ala Cys Asp Ala Asp Asp Ala Asp Asn Ala
    290                 295                 300                 
Ser Lys Leu Ala Ala Met Leu Asn Thr Cys Ser Phe Gln Lys Pro Glu
305                 310                 315                 320 
Gln Leu Gln Gln Gln Lys Ser Val Phe Glu Ile Cys Pro Ser Pro Ala
                325                 330                 335     
Glu Asn Asn Ile Gln Gly Thr Thr Lys Leu Ala Ser Gly Glu Glu Phe
            340                 345                 350         
Cys Ser Gly Ser Ser Ser Asn Leu Gln Ala Pro Gly Gly Ser Ser Glu
        355                 360                 365             
Arg Tyr Leu Lys Gln Asn Glu Met Asn Gly Ala Tyr Phe Lys Gln Ser
    370                 375                 380                 
Ser Val Phe Thr Lys Asp Ser Phe Ser Ala Thr Thr Thr Pro Pro Pro
385                 390                 395                 400 
Pro Ser Gln Leu Leu Leu Ser Pro Pro Pro Pro Leu Pro Gln Val Pro
                405                 410                 415     
Gln Leu Pro Ser Glu Gly Lys Ser Thr Leu Asn Gly Gly Val Leu Glu
            420                 425                 430         
Glu His His His Tyr Pro Asn Gln Ser Asn Thr Thr Leu Leu Arg Glu
        435                 440                 445             
Val Lys Ile Glu Gly Lys Pro Glu Ala Pro Pro Ser Gln Ser Pro Asn
    450                 455                 460                 
Pro Ser Thr His Val Cys Ser Pro Ser Pro Met Leu Ser Glu Arg Pro
465                 470                 475                 480 
Gln Asn Asn Cys Val Asn Arg Asn Asp Ile Gln Thr Ala Gly Thr Met
                485                 490                 495     
Thr Val Pro Leu Cys Ser Glu Lys Thr Arg Pro Met Ser Glu His Leu
            500                 505                 510         
Lys His Asn Pro Pro Ile Phe Gly Ser Ser Gly Glu Leu Gln Asp Asn
        515                 520                 525             
Cys Gln Gln Leu Met Arg Asn Lys Glu Gln Glu Ile Leu Lys Gly Arg
    530                 535                 540                 
Asp Lys Glu Gln Thr Arg Asp Leu Val Pro Pro Thr Gln His Tyr Leu
545                 550                 555                 560 
Lys Pro Gly Trp Ile Glu Leu Lys Ala Pro Arg Phe His Gln Ala Glu
                565                 570                 575     
Ser His Leu Lys Arg Asn Glu Ala Ser Leu Pro Ser Ile Leu Gln Tyr
            580                 585                 590         
Gln Pro Asn Leu Ser Asn Gln Met Thr Ser Lys Gln Tyr Thr Gly Asn
        595                 600                 605             
Ser Asn Met Pro Gly Gly Leu Pro Arg Gln Ala Tyr Thr Gln Lys Thr
    610                 615                 620                 
Thr Gln Leu Glu His Lys Ser Gln Met Tyr Gln Val Glu Met Asn Gln
625                 630                 635                 640 
Gly Gln Ser Gln Gly Thr Val Asp Gln His Leu Gln Phe Gln Lys Pro
                645                 650                 655     
Ser His Gln Val His Phe Ser Lys Thr Asp His Leu Pro Lys Ala His
            660                 665                 670         
Val Gln Ser Leu Cys Gly Thr Arg Phe His Phe Gln Gln Arg Ala Asp
        675                 680                 685             
Ser Gln Thr Glu Lys Leu Met Ser Pro Val Leu Lys Gln His Leu Asn
    690                 695                 700                 
Gln Gln Ala Ser Glu Thr Glu Pro Phe Ser Asn Ser His Leu Leu Gln
705                 710                 715                 720 
His Lys Pro His Lys Gln Ala Ala Gln Thr Gln Pro Ser Gln Ser Ser
                725                 730                 735     
His Leu Pro Gln Asn Gln Gln Gln Gln Gln Lys Leu Gln Ile Lys Asn
            740                 745                 750         
Lys Glu Glu Ile Leu Gln Thr Phe Pro His Pro Gln Ser Asn Asn Asp
        755                 760                 765             
Gln Gln Arg Glu Gly Ser Phe Phe Gly Gln Thr Lys Val Glu Glu Cys
    770                 775                 780                 
Phe His Gly Glu Asn Gln Tyr Ser Lys Ser Ser Glu Phe Glu Thr His
785                 790                 795                 800 
Asn Val Gln Met Gly Leu Glu Glu Val Gln Asn Ile Asn Arg Arg Asn
                805                 810                 815     
Ser Pro Tyr Ser Gln Thr Met Lys Ser Ser Ala Cys Lys Ile Gln Val
            820                 825                 830         
Ser Cys Ser Asn Asn Thr His Leu Val Ser Glu Asn Lys Glu Gln Thr
        835                 840                 845             
Thr His Pro Glu Leu Phe Ala Gly Asn Lys Thr Gln Asn Leu His His
    850                 855                 860                 
Met Gln Tyr Phe Pro Asn Asn Val Ile Pro Lys Gln Asp Leu Leu His
865                 870                 875                 880 
Arg Cys Phe Gln Glu Gln Glu Gln Lys Ser Gln Gln Ala Ser Val Leu
                885                 890                 895     
Gln Gly Tyr Lys Asn Arg Asn Gln Asp Met Ser Gly Gln Gln Ala Ala
            900                 905                 910         
Gln Leu Ala Gln Gln Arg Tyr Leu Ile His Asn His Ala Asn Val Phe
        915                 920                 925             
Pro Val Pro Asp Gln Gly Gly Ser His Thr Gln Thr Pro Pro Gln Lys
    930                 935                 940                 
Asp Thr Gln Lys His Ala Ala Leu Arg Trp His Leu Leu Gln Lys Gln
945                 950                 955                 960 
Glu Gln Gln Gln Thr Gln Gln Pro Gln Thr Glu Ser Cys His Ser Gln
                965                 970                 975     
Met His Arg Pro Ile Lys Val Glu Pro Gly Cys Lys Pro His Ala Cys
            980                 985                 990         
Met His Thr Ala Pro Pro Glu Asn Lys Thr Trp Lys Lys Val Thr Lys
        995                 1000                1005            
Gln Glu Asn Pro Pro Ala Ser Cys Asp Asn Val Gln Gln Lys Ser Ile
    1010                1015                1020                
Ile Glu Thr Met Glu Gln His Leu Lys Gln Phe His Ala Lys Ser Leu
1025                1030                1035                1040
Phe Asp His Lys Ala Leu Thr Leu Lys Ser Gln Lys Gln Val Lys Val
                1045                1050                1055    
Glu Met Ser Gly Pro Val Thr Val Leu Thr Arg Gln Thr Thr Ala Ala
            1060                1065                1070        
Glu Leu Asp Ser His Thr Pro Ala Leu Glu Gln Gln Thr Thr Ser Ser
        1075                1080                1085            
Glu Lys Thr Pro Thr Lys Arg Thr Ala Ala Ser Val Leu Asn Asn Phe
    1090                1095                1100                
Ile Glu Ser Pro Ser Lys Leu Leu Asp Thr Pro Ile Lys Asn Leu Leu
1105                1110                1115                1120
Asp Thr Pro Val Lys Thr Gln Tyr Asp Phe Pro Ser Cys Arg Cys Val
                1125                1130                1135    
Glu Gln Ile Ile Glu Lys Asp Glu Gly Pro Phe Tyr Thr His Leu Gly
            1140                1145                1150        
Ala Gly Pro Asn Val Ala Ala Ile Arg Glu Ile Met Glu Glu Arg Phe
        1155                1160                1165            
Gly Gln Lys Gly Lys Ala Ile Arg Ile Glu Arg Val Ile Tyr Thr Gly
    1170                1175                1180                
Lys Glu Gly Lys Ser Ser Gln Gly Cys Pro Ile Ala Lys Trp Val Val
1185                1190                1195                1200
Arg Arg Ser Ser Ser Glu Glu Lys Leu Leu Cys Leu Val Arg Glu Arg
                1205                1210                1215    
Ala Gly His Thr Cys Glu Ala Ala Val Ile Val Ile Leu Ile Leu Val
            1220                1225                1230        
Trp Glu Gly Ile Pro Leu Ser Leu Ala Asp Lys Leu Tyr Ser Glu Leu
        1235                1240                1245            
Thr Glu Thr Leu Arg Lys Tyr Gly Thr Leu Thr Asn Arg Arg Cys Ala
    1250                1255                1260                
Leu Asn Glu Glu Arg Thr Cys Ala Cys Gln Gly Leu Asp Pro Glu Thr
1265                1270                1275                1280
Cys Gly Ala Ser Phe Ser Phe Gly Cys Ser Trp Ser Met Tyr Tyr Asn
                1285                1290                1295    
Gly Cys Lys Phe Ala Arg Ser Lys Ile Pro Arg Lys Phe Lys Leu Leu
            1300                1305                1310        
Gly Asp Asp Pro Lys Glu Glu Glu Lys Leu Glu Ser His Leu Gln Asn
        1315                1320                1325            
Leu Ser Thr Leu Met Ala Pro Thr Tyr Lys Lys Leu Ala Pro Asp Ala
    1330                1335                1340                
Tyr Asn Asn Gln Ile Glu Tyr Glu His Arg Ala Pro Glu Cys Arg Leu
1345                1350                1355                1360
Gly Leu Lys Glu Gly Arg Pro Phe Ser Gly Val Thr Ala Cys Leu Asp
                1365                1370                1375    
Phe Cys Ala His Ala His Arg Asp Leu His Asn Met Gln Asn Gly Ser
            1380                1385                1390        
Thr Leu Val Cys Thr Leu Thr Arg Glu Asp Asn Arg Glu Phe Gly Gly
        1395                1400                1405            
Lys Pro Glu Asp Glu Gln Leu His Val Leu Pro Leu Tyr Lys Val Ser
    1410                1415                1420                
Asp Val Asp Glu Phe Gly Ser Val Glu Ala Gln Glu Glu Lys Lys Arg
1425                1430                1435                1440
Ser Gly Ala Ile Gln Val Leu Ser Ser Phe Arg Arg Lys Val Arg Met
                1445                1450                1455    
Leu Ala Glu Pro Val Lys Thr Cys Arg Gln Arg Lys Leu Glu Ala Lys
            1460                1465                1470        
Lys Ala Ala Ala Glu Lys Leu Ser Ser Leu Glu Asn Ser Ser Asn Lys
        1475                1480                1485            
Asn Glu Lys Glu Lys Ser Ala Pro Ser Arg Thr Lys Gln Thr Glu Asn
    1490                1495                1500                
Ala Ser Gln Ala Lys Gln Leu Ala Glu Leu Leu Arg Leu Ser Gly Pro
1505                1510                1515                1520
Val Met Gln Gln Ser Gln Gln Pro Gln Pro Leu Gln Lys Gln Pro Pro
                1525                1530                1535    
Gln Pro Gln Gln Gln Gln Arg Pro Gln Gln Gln Gln Pro His His Pro
            1540                1545                1550        
Gln Thr Glu Ser Val Asn Ser Tyr Ser Ala Ser Gly Ser Thr Asn Pro
        1555                1560                1565            
Tyr Met Arg Arg Pro Asn Pro Val Ser Pro Tyr Pro Asn Ser Ser His
    1570                1575                1580                
Thr Ser Asp Ile Tyr Gly Ser Thr Ser Pro Met Asn Phe Tyr Ser Thr
1585                1590                1595                1600
Ser Ser Gln Ala Ala Gly Ser Tyr Leu Asn Ser Ser Asn Pro Met Asn
                1605                1610                1615    
Pro Tyr Pro Gly Leu Leu Asn Gln Asn Thr Gln Tyr Pro Ser Tyr Gln
            1620                1625                1630        
Cys Asn Gly Asn Leu Ser Val Asp Asn Cys Ser Pro Tyr Leu Gly Ser
        1635                1640                1645            
Tyr Ser Pro Gln Ser Gln Pro Met Asp Leu Tyr Arg Tyr Pro Ser Gln
    1650                1655                1660                
Asp Pro Leu Ser Lys Leu Ser Leu Pro Pro Ile His Thr Leu Tyr Gln
1665                1670                1675                1680
Pro Arg Phe Gly Asn Ser Gln Ser Phe Thr Ser Lys Tyr Leu Gly Tyr
                1685                1690                1695    
Gly Asn Gln Asn Met Gln Gly Asp Gly Phe Ser Ser Cys Thr Ile Arg
            1700                1705                1710        
Pro Asn Val His His Val Gly Lys Leu Pro Pro Tyr Pro Thr His Glu
        1715                1720                1725            
Met Asp Gly His Phe Met Gly Ala Thr Ser Arg Leu Pro Pro Asn Leu
    1730                1735                1740                
Ser Asn Pro Asn Met Asp Tyr Lys Asn Gly Glu His His Ser Pro Ser
1745                1750                1755                1760
His Ile Ile His Asn Tyr Ser Ala Ala Pro Gly Met Phe Asn Ser Ser
                1765                1770                1775    
Leu His Ala Leu His Leu Gln Asn Lys Glu Asn Asp Met Leu Ser His
            1780                1785                1790        
Thr Ala Asn Gly Leu Ser Lys Met Leu Pro Ala Leu Asn His Asp Arg
        1795                1800                1805            
Thr Ala Cys Val Gln Gly Gly Leu His Lys Leu Ser Asp Ala Asn Gly
    1810                1815                1820                
Gln Glu Lys Gln Pro Leu Ala Leu Val Gln Gly Val Ala Ser Gly Ala
1825                1830                1835                1840
Glu Asp Asn Asp Glu Val Trp Ser Asp Ser Glu Gln Ser Phe Leu Asp
                1845                1850                1855    
Pro Asp Ile Gly Gly Val Ala Val Ala Pro Thr His Gly Ser Ile Leu
            1860                1865                1870        
Ile Glu Cys Ala Lys Arg Glu Leu His Ala Thr Thr Pro Leu Lys Asn
        1875                1880                1885            
Pro Asn Arg Asn His Pro Thr Arg Ile Ser Leu Val Phe Tyr Gln His
    1890                1895                1900                
Lys Ser Met Asn Glu Pro Lys His Gly Leu Ala Leu Trp Glu Ala Lys
1905                1910                1915                1920
Met Ala Glu Lys Ala Arg Glu Lys Glu Glu Glu Cys Glu Lys Tyr Gly
                1925                1930                1935    
Pro Asp Tyr Val Pro Gln Lys Ser His Gly Lys Lys Val Lys Arg Glu
            1940                1945                1950        
Pro Ala Glu Pro His Glu Thr Ser Glu Pro Thr Tyr Leu Arg Phe Ile
        1955                1960                1965            
Lys Ser Leu Ala Glu Arg Thr Met Ser Val Thr Thr Asp Ser Thr Val
    1970                1975                1980                
Thr Thr Ser Pro Tyr Ala Phe Thr Arg Val Thr Gly Pro Tyr Asn Arg
1985                1990                1995                2000
Tyr Ile
        


<210> 6168
<211> 2946
<212> PRT
<213> Homo sapiens

<400> 6168
Met Ala Ser Glu Lys Pro Gly Pro Gly Pro Gly Leu Glu Pro Gln Pro
 1               5                  10                  15      
Val Gly Leu Ile Ala Val Gly Ala Ala Gly Gly Gly Gly Gly Gly Ser
            20                  25                  30          
Gly Gly Gly Gly Thr Gly Gly Ser Gly Met Gly Glu Leu Arg Gly Ala
        35                  40                  45              
Ser Gly Ser Gly Ser Val Met Leu Pro Ala Gly Met Ile Asn Pro Ser
    50                  55                  60                  
Val Pro Ile Arg Asn Ile Arg Met Lys Phe Ala Val Leu Ile Gly Leu
65                  70                  75                  80  
Ile Gln Val Gly Glu Val Ser Asn Arg Asp Ile Val Glu Thr Val Leu
                85                  90                  95      
Asn Leu Leu Val Gly Gly Glu Phe Asp Leu Glu Met Asn Phe Ile Ile
            100                 105                 110         
Gln Asp Ala Glu Ser Ile Thr Cys Met Thr Glu Leu Leu Glu His Cys
        115                 120                 125             
Asp Val Thr Cys Gln Ala Glu Ile Trp Ser Met Phe Thr Ala Ile Leu
    130                 135                 140                 
Arg Lys Ser Val Arg Asn Leu Gln Thr Ser Thr Glu Val Gly Leu Ile
145                 150                 155                 160 
Glu Gln Val Leu Leu Lys Met Ser Ala Val Asp Asp Met Ile Ala Asp
                165                 170                 175     
Leu Leu Val Asp Met Leu Gly Val Leu Ala Ser Tyr Ser Ile Thr Val
            180                 185                 190         
Lys Glu Leu Lys Leu Leu Phe Ser Met Leu Arg Gly Glu Ser Gly Ile
        195                 200                 205             
Trp Pro Arg His Ala Val Lys Leu Leu Ser Val Leu Asn Gln Met Pro
    210                 215                 220                 
Gln Arg His Gly Pro Asp Thr Phe Phe Asn Phe Pro Gly Cys Ser Ala
225                 230                 235                 240 
Ala Ala Ile Ala Leu Pro Pro Ile Ala Lys Trp Pro Tyr Gln Asn Gly
                245                 250                 255     
Phe Thr Leu Asn Thr Trp Phe Arg Met Asp Pro Leu Asn Asn Ile Asn
            260                 265                 270         
Val Asp Lys Asp Lys Pro Tyr Leu Tyr Cys Phe Arg Thr Ser Lys Gly
        275                 280                 285             
Val Gly Tyr Ser Ala His Phe Val Gly Asn Cys Leu Ile Val Thr Ser
    290                 295                 300                 
Leu Lys Ser Lys Gly Lys Gly Phe Gln His Cys Val Lys Tyr Asp Phe
305                 310                 315                 320 
Gln Pro Arg Lys Trp Tyr Met Ile Ser Ile Val His Ile Tyr Asn Arg
                325                 330                 335     
Trp Arg Asn Ser Glu Ile Arg Cys Tyr Val Asn Gly Gln Leu Val Ser
            340                 345                 350         
Tyr Gly Asp Met Ala Trp His Val Asn Thr Asn Asp Ser Tyr Asp Lys
        355                 360                 365             
Cys Phe Leu Gly Ser Ser Glu Thr Ala Asp Ala Asn Arg Val Phe Cys
    370                 375                 380                 
Gly Gln Leu Gly Ala Val Tyr Val Phe Ser Glu Ala Leu Asn Pro Ala
385                 390                 395                 400 
Gln Ile Phe Ala Ile His Gln Leu Gly Pro Gly Tyr Lys Ser Thr Phe
                405                 410                 415     
Lys Phe Lys Ser Glu Ser Asp Ile His Leu Ala Glu His His Lys Gln
            420                 425                 430         
Val Leu Tyr Asp Gly Lys Leu Ala Ser Ser Ile Ala Phe Thr Tyr Asn
        435                 440                 445             
Ala Lys Ala Thr Asp Ala Gln Leu Cys Leu Glu Ser Ser Pro Lys Glu
    450                 455                 460                 
Asn Ala Ser Ile Phe Val His Ser Pro His Ala Leu Met Leu Gln Asp
465                 470                 475                 480 
Val Lys Ala Ile Val Thr His Ser Ile His Ser Ala Ile His Ser Ile
                485                 490                 495     
Gly Gly Ile Gln Val Leu Phe Pro Leu Phe Ala Gln Leu Asp Asn Arg
            500                 505                 510         
Gln Leu Asn Asp Ser Gln Val Glu Thr Thr Val Cys Ala Thr Leu Leu
        515                 520                 525             
Ala Phe Leu Val Glu Leu Leu Lys Ser Ser Val Ala Met Gln Glu Gln
    530                 535                 540                 
Met Leu Gly Gly Lys Gly Phe Leu Val Ile Gly Tyr Leu Leu Glu Lys
545                 550                 555                 560 
Ser Ser Arg Val His Ile Thr Arg Ala Val Leu Glu Gln Phe Leu Ser
                565                 570                 575     
Phe Ala Lys Tyr Leu Asp Gly Leu Ser His Gly Ala Pro Leu Leu Lys
            580                 585                 590         
Gln Leu Cys Asp His Ile Leu Phe Asn Pro Ala Ile Trp Ile His Thr
        595                 600                 605             
Pro Ala Lys Val Gln Leu Ser Leu Tyr Thr Tyr Leu Ser Ala Glu Phe
    610                 615                 620                 
Ile Gly Thr Ala Thr Ile Tyr Thr Thr Ile Arg Arg Val Gly Thr Val
625                 630                 635                 640 
Leu Gln Leu Met His Thr Leu Lys Tyr Tyr Tyr Trp Val Ile Asn Pro
                645                 650                 655     
Ala Asp Ser Ser Gly Ile Thr Pro Lys Gly Leu Asp Gly Pro Arg Pro
            660                 665                 670         
Ser Gln Lys Glu Ile Ile Ser Leu Arg Ala Phe Met Leu Leu Phe Leu
        675                 680                 685             
Lys Gln Leu Ile Leu Lys Asp Arg Gly Val Lys Glu Asp Glu Leu Gln
    690                 695                 700                 
Ser Ile Leu Asn Tyr Leu Leu Thr Met His Glu Asp Glu Asn Ile His
705                 710                 715                 720 
Asp Val Leu Gln Leu Leu Val Ala Leu Met Ser Glu His Pro Ala Ser
                725                 730                 735     
Met Ile Pro Ala Phe Asp Gln Arg Asn Gly Ile Arg Val Ile Tyr Lys
            740                 745                 750         
Leu Leu Ala Ser Lys Ser Glu Ser Ile Trp Val Gln Ala Leu Lys Val
        755                 760                 765             
Leu Gly Tyr Phe Leu Lys His Leu Gly His Lys Arg Lys Val Glu Ile
    770                 775                 780                 
Met His Thr His Ser Leu Phe Thr Leu Leu Gly Glu Arg Leu Met Leu
785                 790                 795                 800 
His Thr Asn Thr Val Thr Val Thr Thr Tyr Asn Thr Leu Tyr Glu Ile
                805                 810                 815     
Leu Thr Glu Gln Val Cys Thr Gln Val Val His Lys Pro His Pro Glu
            820                 825                 830         
Pro Asp Ser Thr Val Lys Ile Gln Asn Pro Met Ile Leu Lys Val Val
        835                 840                 845             
Ala Thr Leu Leu Lys Asn Ser Thr Pro Ser Ala Glu Leu Met Glu Val
    850                 855                 860                 
Arg Arg Leu Phe Leu Ser Asp Met Ile Lys Leu Phe Ser Asn Ser Arg
865                 870                 875                 880 
Glu Asn Arg Arg Cys Leu Leu Gln Cys Ser Val Trp Gln Asp Trp Met
                885                 890                 895     
Phe Ser Leu Gly Tyr Ile Asn Pro Lys Asn Ser Glu Glu Gln Lys Ile
            900                 905                 910         
Thr Glu Met Val Tyr Asn Ile Phe Arg Ile Leu Leu Tyr His Ala Ile
        915                 920                 925             
Lys Tyr Glu Trp Gly Gly Trp Arg Val Trp Val Asp Thr Leu Ser Ile
    930                 935                 940                 
Ala His Ser Lys Val Thr Tyr Glu Ala His Lys Glu Tyr Leu Ala Lys
945                 950                 955                 960 
Met Tyr Glu Glu Tyr Gln Arg Gln Glu Glu Glu Asn Ile Lys Lys Gly
                965                 970                 975     
Lys Lys Gly Asn Val Ser Thr Ile Ser Gly Leu Ser Ser Gln Thr Thr
            980                 985                 990         
Gly Ala Lys Gly Gly Met Glu Ile Arg Glu Ile Glu Asp Leu Ser Gln
        995                 1000                1005            
Ser Gln Ser Pro Glu Ser Glu Thr Asp Tyr Pro Val Ser Thr Asp Thr
    1010                1015                1020                
Arg Asp Leu Leu Met Ser Thr Lys Val Ser Asp Asp Ile Leu Gly Asn
1025                1030                1035                1040
Ser Asp Arg Pro Gly Ser Gly Val His Val Glu Val His Asp Leu Leu
                1045                1050                1055    
Val Asp Ile Lys Ala Glu Lys Val Glu Ala Thr Glu Val Lys Leu Asp
            1060                1065                1070        
Asp Met Asp Leu Ser Pro Glu Thr Leu Val Gly Gly Glu Asn Gly Ala
        1075                1080                1085            
Leu Val Glu Val Glu Ser Leu Leu Asp Asn Val Tyr Ser Ala Ala Val
    1090                1095                1100                
Glu Lys Leu Gln Asn Asn Val His Gly Ser Val Gly Ile Ile Lys Lys
1105                1110                1115                1120
Asn Glu Glu Lys Asp Asn Gly Pro Leu Ile Thr Leu Ala Asp Glu Lys
                1125                1130                1135    
Glu Asp Leu Pro Asn Ser Ser Thr Ser Phe Leu Phe Asp Lys Ile Pro
            1140                1145                1150        
Lys Gln Glu Glu Lys Leu Leu Pro Glu Leu Ser Ser Asn His Ile Ile
        1155                1160                1165            
Pro Asn Ile Gln Asp Thr Gln Val His Leu Gly Val Ser Asp Asp Leu
    1170                1175                1180                
Gly Leu Leu Ala His Met Thr Gly Ser Val Asp Leu Thr Cys Thr Ser
1185                1190                1195                1200
Ser Ile Ile Glu Glu Lys Glu Phe Lys Ile His Thr Thr Ser Asp Gly
                1205                1210                1215    
Met Ser Ser Ile Ser Glu Arg Asp Leu Ala Ser Ser Thr Lys Gly Leu
            1220                1225                1230        
Glu Tyr Ala Glu Met Thr Ala Thr Thr Leu Glu Thr Glu Ser Ser Ser
        1235                1240                1245            
Ser Lys Ile Val Pro Asn Ile Asp Ala Gly Ser Ile Ile Ser Asp Thr
    1250                1255                1260                
Glu Arg Ser Asp Asp Gly Lys Glu Ser Gly Lys Glu Ile Arg Lys Ile
1265                1270                1275                1280
Gln Thr Thr Thr Thr Thr Gln Ala Val Gln Gly Arg Ser Ile Thr Gln
                1285                1290                1295    
Gln Asp Arg Asp Leu Arg Val Asp Leu Gly Phe Arg Gly Met Pro Met
            1300                1305                1310        
Thr Glu Glu Gln Arg Arg Gln Phe Ser Pro Gly Pro Arg Thr Thr Met
        1315                1320                1325            
Phe Arg Ile Pro Glu Phe Lys Trp Ser Pro Met His Gln Arg Leu Leu
    1330                1335                1340                
Thr Asp Leu Leu Phe Ala Leu Glu Thr Asp Val His Val Trp Arg Ser
1345                1350                1355                1360
His Ser Thr Lys Ser Val Met Asp Phe Val Asn Ser Asn Glu Asn Ile
                1365                1370                1375    
Ile Phe Val His Asn Thr Ile His Leu Ile Ser Gln Met Val Asp Asn
            1380                1385                1390        
Ile Ile Ile Ala Cys Gly Gly Ile Leu Pro Leu Leu Ser Ala Ala Thr
        1395                1400                1405            
Ser Pro Thr Gly Ser Lys Thr Glu Leu Glu Asn Ile Glu Val Thr Gln
    1410                1415                1420                
Gly Met Ser Ala Glu Thr Ala Val Thr Phe Leu Ser Arg Leu Met Ala
1425                1430                1435                1440
Met Val Asp Val Leu Val Phe Ala Ser Ser Leu Asn Phe Ser Glu Ile
                1445                1450                1455    
Glu Ala Glu Lys Asn Met Ser Ser Gly Gly Leu Met Arg Gln Cys Leu
            1460                1465                1470        
Arg Leu Val Cys Cys Val Ala Val Arg Asn Cys Leu Glu Cys Arg Gln
        1475                1480                1485            
Arg Gln Arg Asp Arg Gly Asn Lys Ser Ser His Gly Ser Ser Lys Pro
    1490                1495                1500                
Gln Glu Val Pro Gln Ser Val Thr Ala Thr Ala Ala Ser Lys Thr Pro
1505                1510                1515                1520
Leu Glu Asn Val Pro Gly Asn Leu Ser Pro Ile Lys Asp Pro Asp Arg
                1525                1530                1535    
Leu Leu Gln Asp Val Asp Ile Asn Arg Leu Arg Ala Val Val Phe Arg
            1540                1545                1550        
Asp Val Asp Asp Ser Lys Gln Ala Gln Phe Leu Ala Leu Ala Val Val
        1555                1560                1565            
Tyr Phe Ile Ser Val Leu Met Val Ser Lys Tyr Arg Asp Ile Leu Glu
    1570                1575                1580                
Pro Gln Arg Glu Thr Thr Arg Thr Gly Ser Gln Pro Gly Arg Asn Ile
1585                1590                1595                1600
Arg Gln Glu Ile Asn Ser Pro Thr Ser Thr Val Val Val Ile Pro Ser
                1605                1610                1615    
Ile Pro His Pro Ser Leu Asn His Gly Phe Leu Ala Lys Leu Ile Pro
            1620                1625                1630        
Glu Gln Ser Phe Gly His Ser Phe Tyr Lys Glu Thr Pro Ala Ala Phe
        1635                1640                1645            
Pro Asp Thr Ile Lys Glu Lys Glu Thr Ser Thr Pro Gly Glu Asp Ile
    1650                1655                1660                
Gln Val Glu Ser Ser Ile Pro His Thr Asp Ser Gly Ile Gly Glu Glu
1665                1670                1675                1680
Gln Val Ala Ser Ile Leu Asn Gly Ala Glu Leu Glu Thr Ser Thr Gly
                1685                1690                1695    
Pro Asp Ala Met Ser Glu Leu Leu Ser Thr Leu Ser Ser Glu Val Lys
            1700                1705                1710        
Lys Ser Gln Glu Ser Leu Thr Glu Asn Pro Ser Glu Thr Leu Lys Pro
        1715                1720                1725            
Ala Thr Ser Ile Ser Ser Ile Ser Gln Thr Lys Gly Ile Asn Val Lys
    1730                1735                1740                
Glu Ile Leu Lys Ser Leu Val Ala Ala Pro Val Glu Ile Ala Glu Cys
1745                1750                1755                1760
Gly Pro Glu Pro Ile Pro Tyr Pro Asp Pro Ala Leu Lys Arg Glu Thr
                1765                1770                1775    
Gln Ala Ile Leu Pro Met Gln Phe His Ser Phe Asp Arg Ser Val Val
            1780                1785                1790        
Val Pro Val Lys Lys Pro Pro Pro Gly Ser Leu Ala Val Thr Thr Val
        1795                1800                1805            
Gly Ala Thr Thr Ala Gly Ser Gly Leu Pro Thr Gly Ser Thr Ser Asn
    1810                1815                1820                
Ile Phe Ala Ala Thr Gly Ala Thr Pro Lys Ser Met Ile Asn Thr Thr
1825                1830                1835                1840
Gly Ala Val Asp Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Phe
                1845                1850                1855    
Val Asn Gly Ala Thr Ser Lys Asn Leu Pro Ala Val Gln Thr Val Ala
            1860                1865                1870        
Pro Met Pro Glu Asp Ser Ala Glu Asn Met Ser Ile Thr Ala Lys Leu
        1875                1880                1885            
Glu Arg Ala Leu Glu Lys Val Ala Pro Leu Leu Arg Glu Ile Phe Val
    1890                1895                1900                
Asp Phe Ala Pro Phe Leu Ser Arg Thr Leu Leu Gly Ser His Gly Gln
1905                1910                1915                1920
Glu Leu Leu Ile Glu Gly Leu Val Cys Met Lys Ser Ser Thr Ser Val
                1925                1930                1935    
Val Glu Leu Val Met Leu Leu Cys Ser Gln Glu Trp Gln Asn Ser Ile
            1940                1945                1950        
Gln Lys Asn Ala Gly Leu Ala Phe Ile Glu Leu Ile Asn Glu Gly Arg
        1955                1960                1965            
Leu Leu Cys His Ala Met Lys Asp His Ile Val Arg Val Ala Asn Glu
    1970                1975                1980                
Ala Glu Phe Ile Leu Asn Arg Gln Arg Ala Glu Asp Val His Lys His
1985                1990                1995                2000
Ala Glu Phe Glu Ser Gln Cys Ala Gln Tyr Ala Ala Asp Arg Arg Glu
                2005                2010                2015    
Glu Glu Lys Met Cys Asp His Leu Ile Ser Ala Ala Lys His Arg Asp
            2020                2025                2030        
His Val Thr Ala Asn Gln Leu Lys Gln Lys Ile Leu Asn Ile Leu Thr
        2035                2040                2045            
Asn Lys His Gly Ala Trp Gly Ala Val Ser His Ser Gln Leu His Asp
    2050                2055                2060                
Phe Trp Arg Leu Asp Tyr Trp Glu Asp Asp Leu Arg Arg Arg Arg Arg
2065                2070                2075                2080
Phe Val Arg Asn Ala Phe Gly Ser Thr His Ala Glu Ala Leu Leu Lys
                2085                2090                2095    
Ala Ala Ile Glu Tyr Gly Thr Glu Glu Asp Val Val Lys Ser Lys Lys
            2100                2105                2110        
Thr Phe Arg Ser Gln Ala Ile Val Asn Gln Asn Ala Glu Thr Glu Leu
        2115                2120                2125            
Met Leu Glu Gly Asp Asp Asp Ala Val Ser Leu Leu Gln Glu Lys Glu
    2130                2135                2140                
Ile Asp Asn Leu Ala Gly Pro Val Val Leu Ser Thr Pro Ala Gln Leu
2145                2150                2155                2160
Ile Ala Pro Val Val Val Ala Lys Gly Thr Leu Ser Ile Thr Thr Thr
                2165                2170                2175    
Glu Ile Tyr Phe Glu Val Asp Glu Asp Asp Ser Ala Phe Lys Lys Ile
            2180                2185                2190        
Asp Thr Lys Val Leu Ala Tyr Thr Glu Gly Leu His Gly Lys Trp Met
        2195                2200                2205            
Phe Ser Glu Ile Arg Ala Val Phe Ser Arg Arg Tyr Leu Leu Gln Asn
    2210                2215                2220                
Thr Ala Leu Glu Val Phe Met Ala Asn Arg Thr Ser Val Met Phe Asn
2225                2230                2235                2240
Phe Pro Asp Gln Ala Thr Val Lys Lys Val Val Tyr Ser Leu Pro Arg
                2245                2250                2255    
Val Gly Val Gly Thr Ser Tyr Gly Leu Pro Gln Ala Arg Arg Ile Ser
            2260                2265                2270        
Leu Ala Thr Pro Arg Gln Leu Tyr Lys Ser Ser Asn Met Thr Gln Arg
        2275                2280                2285            
Trp Gln Arg Arg Glu Ile Ser Asn Phe Glu Tyr Leu Met Phe Leu Asn
    2290                2295                2300                
Thr Ile Ala Gly Arg Thr Tyr Asn Asp Leu Asn Gln Tyr Pro Val Phe
2305                2310                2315                2320
Pro Trp Val Leu Thr Asn Tyr Glu Ser Glu Glu Leu Asp Leu Thr Leu
                2325                2330                2335    
Pro Gly Asn Phe Arg Asp Leu Ser Lys Pro Ile Gly Ala Leu Asn Pro
            2340                2345                2350        
Lys Arg Ala Val Phe Tyr Ala Glu Arg Tyr Glu Thr Trp Glu Asp Asp
        2355                2360                2365            
Gln Ser Pro Pro Tyr His Tyr Asn Thr His Tyr Ser Thr Ala Thr Ser
    2370                2375                2380                
Thr Leu Ser Trp Leu Val Arg Ile Glu Pro Phe Thr Thr Phe Phe Leu
2385                2390                2395                2400
Asn Ala Asn Asp Gly Lys Phe Asp His Pro Asp Arg Thr Phe Ser Ser
                2405                2410                2415    
Val Ala Arg Ser Trp Arg Thr Ser Gln Arg Asp Thr Ser Asp Val Lys
            2420                2425                2430        
Glu Leu Ile Pro Glu Phe Tyr Tyr Leu Pro Glu Met Phe Val Asn Ser
        2435                2440                2445            
Asn Gly Tyr Asn Leu Gly Val Arg Glu Asp Glu Val Val Val Asn Asp
    2450                2455                2460                
Val Asp Leu Pro Pro Trp Ala Lys Lys Pro Glu Asp Phe Val Arg Ile
2465                2470                2475                2480
Asn Arg Met Ala Leu Glu Ser Glu Phe Val Ser Cys Gln Leu His Gln
                2485                2490                2495    
Trp Ile Asp Leu Ile Phe Gly Tyr Lys Gln Arg Gly Pro Glu Ala Val
            2500                2505                2510        
Arg Ala Leu Asn Val Phe His Tyr Leu Thr Tyr Glu Gly Ser Val Asn
        2515                2520                2525            
Leu Asp Ser Ile Thr Asp Pro Val Leu Arg Glu Ala Met Glu Ala Gln
    2530                2535                2540                
Ile Gln Asn Phe Gly Gln Thr Pro Ser Gln Leu Leu Ile Glu Pro His
2545                2550                2555                2560
Pro Pro Arg Ser Ser Ala Met His Leu Cys Phe Leu Pro Gln Ser Pro
                2565                2570                2575    
Leu Met Phe Lys Asp Gln Met Gln Gln Asp Val Ile Met Val Leu Lys
            2580                2585                2590        
Phe Pro Ser Asn Ser Pro Val Thr His Val Ala Ala Asn Thr Leu Pro
        2595                2600                2605            
His Leu Thr Ile Pro Ala Val Val Thr Val Thr Cys Ser Arg Leu Phe
    2610                2615                2620                
Ala Val Asn Arg Trp His Asn Thr Val Gly Leu Arg Gly Ala Pro Gly
2625                2630                2635                2640
Tyr Ser Leu Asp Gln Ala His His Leu Pro Ile Glu Met Asp Pro Leu
                2645                2650                2655    
Ile Ala Asn Asn Ser Gly Val Asn Lys Arg Gln Ile Thr Asp Leu Val
            2660                2665                2670        
Asp Gln Ser Ile Gln Ile Asn Ala His Cys Phe Val Val Thr Ala Asp
        2675                2680                2685            
Asn Arg Tyr Ile Leu Ile Cys Gly Phe Trp Asp Lys Ser Phe Arg Val
    2690                2695                2700                
Tyr Ser Thr Glu Thr Gly Lys Leu Thr Gln Ile Val Phe Gly His Trp
2705                2710                2715                2720
Asp Val Val Thr Cys Leu Ala Arg Ser Glu Ser Tyr Ile Gly Gly Asp
                2725                2730                2735    
Cys Tyr Ile Val Ser Gly Ser Arg Asp Ala Thr Leu Leu Leu Trp Tyr
            2740                2745                2750        
Trp Ser Gly Arg His His Ile Ile Gly Asp Asn Pro Asn Ser Ser Asp
        2755                2760                2765            
Tyr Pro Ala Pro Arg Ala Val Leu Thr Gly His Asp His Glu Val Val
    2770                2775                2780                
Cys Val Ser Val Cys Ala Glu Leu Gly Leu Val Ile Ser Gly Ala Lys
2785                2790                2795                2800
Glu Gly Pro Cys Leu Val His Thr Ile Thr Gly Asp Leu Leu Arg Ala
                2805                2810                2815    
Leu Glu Gly Pro Glu Asn Cys Leu Phe Pro Arg Leu Ile Ser Val Ser
            2820                2825                2830        
Ser Glu Gly His Cys Ile Ile Tyr Tyr Glu Arg Gly Arg Phe Ser Asn
        2835                2840                2845            
Phe Ser Ile Asn Gly Lys Leu Leu Ala Gln Met Glu Ile Asn Asp Ser
    2850                2855                2860                
Thr Arg Ala Ile Leu Leu Ser Ser Asp Gly Gln Asn Leu Val Thr Gly
2865                2870                2875                2880
Gly Asp Asn Gly Val Val Glu Val Trp Gln Ala Cys Asp Phe Lys Gln
                2885                2890                2895    
Leu Tyr Ile Tyr Pro Gly Cys Asp Ala Gly Ile Arg Ala Met Asp Leu
            2900                2905                2910        
Ser His Asp Gln Arg Thr Leu Ile Thr Gly Met Ala Ser Gly Ser Ile
        2915                2920                2925            
Val Ala Phe Asn Ile Asp Phe Asn Arg Trp His Tyr Glu His Gln Asn
    2930                2935                2940                
Arg Tyr
2945    


<210> 6169
<211> 2174
<212> PRT
<213> Homo sapiens

<400> 6169
Met Ser Ala Ser Phe Val Pro Asn Gly Ala Ser Leu Glu Asp Cys His
 1               5                  10                  15      
Cys Asn Leu Phe Cys Leu Ala Asp Leu Thr Gly Ile Lys Trp Lys Lys
            20                  25                  30          
Tyr Val Trp Gln Gly Pro Thr Ser Ala Pro Ile Leu Phe Pro Val Thr
        35                  40                  45              
Glu Glu Asp Pro Ile Leu Ser Ser Phe Ser Arg Cys Leu Lys Ala Asp
    50                  55                  60                  
Val Leu Gly Val Trp Arg Arg Asp Gln Arg Pro Gly Arg Arg Glu Leu
65                  70                  75                  80  
Trp Ile Phe Trp Trp Gly Glu Asp Pro Val Leu Leu Thr Leu Phe Thr
                85                  90                  95      
Met Thr Tyr Gln Lys Lys Lys Met Glu Cys Gly Arg Met Asp Phe Pro
            100                 105                 110         
Met Asn Ala Val Leu Cys Phe Ser Lys Ala Val His Asn Leu Leu Glu
        115                 120                 125             
Arg Cys Leu Met Asn Arg Asn Phe Val Arg Ile Gly Lys Trp Phe Val
    130                 135                 140                 
Lys Pro Tyr Glu Lys Asp Glu Lys Pro Ile Asn Lys Ser Glu His Leu
145                 150                 155                 160 
Ser Cys Ser Phe Thr Phe Phe Leu His Gly Asp Ser Asn Val Cys Thr
                165                 170                 175     
Ser Val Glu Ile Asn Gln His Gln Pro Val Tyr Leu Leu Ser Glu Glu
            180                 185                 190         
His Ile Thr Leu Ala Gln Gln Ser Asn Ser Pro Phe Gln Val Ile Leu
        195                 200                 205             
Cys Pro Phe Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala Phe Lys Met
    210                 215                 220                 
Ser Asp Ser Ala Thr Lys Lys Leu Ile Gly Glu Trp Lys Gln Phe Tyr
225                 230                 235                 240 
Pro Ile Ser Cys Cys Leu Lys Glu Met Ser Glu Glu Lys Gln Glu Asp
                245                 250                 255     
Met Asp Trp Glu Asp Asp Ser Leu Ala Ala Val Glu Val Leu Val Ala
            260                 265                 270         
Gly Val Arg Met Ile Tyr Pro Ala Cys Phe Val Leu Val Pro Gln Ser
        275                 280                 285             
Asp Ile Pro Thr Pro Ser Pro Val Gly Ser Thr His Cys Ser Ser Ser
    290                 295                 300                 
Cys Leu Gly Val His Gln Val Pro Ala Ser Thr Arg Asp Pro Ala Met
305                 310                 315                 320 
Ser Ser Val Thr Leu Thr Pro Pro Thr Ser Pro Glu Glu Val Gln Thr
                325                 330                 335     
Val Asp Pro Gln Ser Val Gln Lys Trp Val Lys Phe Ser Ser Val Ser
            340                 345                 350         
Asp Gly Phe Asn Ser Asp Ser Thr Ser His His Gly Gly Lys Ile Pro
        355                 360                 365             
Arg Lys Leu Ala Asn His Val Val Asp Arg Val Trp Gln Glu Cys Asn
    370                 375                 380                 
Met Asn Arg Ala Gln Asn Lys Lys Lys Tyr Ser Ala Ser Ser Gly Gly
385                 390                 395                 400 
Leu Cys Glu Glu Ala Thr Ala Ala Lys Val Ala Ser Trp Asp Phe Val
                405                 410                 415     
Glu Ala Thr Gln Arg Thr Asn Cys Ser Cys Leu Arg His Lys Asn Leu
            420                 425                 430         
Lys Ser Arg Asn Ala Gly Gln Gln Gly Gln Ala Pro Ser Leu Gly Gln
        435                 440                 445             
Gln Gln Gln Ile Leu Pro Lys His Lys Thr Asn Glu Lys Gln Glu Lys
    450                 455                 460                 
Ser Glu Glu Pro Gln Lys Arg Pro Leu Thr Pro Phe His His Arg Val
465                 470                 475                 480 
Ser Val Ser Asp Asp Val Gly Met Asp Ala Asp Ser Ala Ser Gln Arg
                485                 490                 495     
Leu Val Ile Ser Ala Pro Asp Ser Gln Val Arg Phe Ser Asn Ile Arg
            500                 505                 510         
Thr Asn Asp Val Ala Lys Thr Pro Gln Met His Gly Thr Glu Met Ala
        515                 520                 525             
Asn Ser Pro Gln Pro Pro Pro Leu Ser Pro His Pro Cys Asp Val Val
    530                 535                 540                 
Asp Glu Gly Val Thr Lys Thr Pro Ser Thr Pro Gln Ser Gln His Phe
545                 550                 555                 560 
Tyr Gln Met Pro Thr Pro Asp Pro Leu Val Pro Ser Lys Pro Met Glu
                565                 570                 575     
Asp Arg Ile Asp Ser Leu Ser Gln Ser Phe Pro Pro Gln Tyr Gln Glu
            580                 585                 590         
Ala Val Glu Pro Thr Val Tyr Val Gly Thr Ala Val Asn Leu Glu Glu
        595                 600                 605             
Asp Glu Ala Asn Ile Ala Trp Lys Tyr Tyr Lys Phe Pro Lys Lys Lys
    610                 615                 620                 
Asp Val Glu Phe Leu Pro Pro Gln Leu Pro Ser Asp Lys Phe Lys Asp
625                 630                 635                 640 
Asp Pro Val Gly Pro Phe Gly Gln Glu Ser Val Thr Ser Val Thr Glu
                645                 650                 655     
Leu Met Val Gln Cys Lys Lys Pro Leu Lys Val Ser Asp Glu Leu Val
            660                 665                 670         
Gln Gln Tyr Gln Ile Lys Asn Gln Cys Leu Ser Ala Ile Ala Ser Asp
        675                 680                 685             
Ala Glu Gln Glu Pro Lys Ile Asp Pro Tyr Ala Phe Val Glu Gly Asp
    690                 695                 700                 
Glu Glu Phe Leu Phe Pro Asp Lys Lys Asp Arg Gln Asn Ser Glu Arg
705                 710                 715                 720 
Glu Ala Gly Lys Lys His Lys Val Glu Asp Gly Thr Ser Ser Val Thr
                725                 730                 735     
Val Leu Ser His Glu Glu Asp Ala Met Ser Leu Phe Ser Pro Ser Ile
            740                 745                 750         
Lys Gln Asp Ala Pro Arg Pro Thr Ser His Ala Arg Pro Pro Ser Thr
        755                 760                 765             
Ser Leu Ile Tyr Asp Ser Asp Leu Ala Val Ser Tyr Thr Asp Leu Asp
    770                 775                 780                 
Asn Leu Phe Asn Ser Asp Glu Asp Glu Leu Thr Pro Gly Ser Lys Arg
785                 790                 795                 800 
Ser Ala Asn Gly Ser Asp Asp Lys Ala Ser Cys Lys Glu Ser Lys Thr
                805                 810                 815     
Gly Asn Leu Asp Pro Leu Ser Cys Ile Ser Thr Ala Asp Leu His Lys
            820                 825                 830         
Met Tyr Pro Thr Pro Pro Ser Leu Glu Gln His Ile Met Gly Phe Ser
        835                 840                 845             
Pro Met Asn Met Asn Asn Lys Glu Tyr Gly Ser Met Asp Thr Thr Pro
    850                 855                 860                 
Gly Gly Thr Val Leu Glu Gly Asn Ser Ser Ser Ile Gly Ala Gln Phe
865                 870                 875                 880 
Lys Ile Glu Val Asp Glu Gly Phe Cys Ser Pro Lys Pro Ser Glu Ile
                885                 890                 895     
Lys Asp Phe Ser Tyr Val Tyr Lys Pro Glu Asn Cys Gln Ile Leu Val
            900                 905                 910         
Gly Cys Ser Met Phe Ala Pro Leu Lys Thr Leu Pro Ser Gln Tyr Leu
        915                 920                 925             
Pro Leu Ile Lys Leu Pro Glu Glu Cys Ile Tyr Arg Gln Ser Trp Thr
    930                 935                 940                 
Val Gly Lys Leu Glu Leu Leu Ser Ser Gly Pro Ser Met Pro Phe Ile
945                 950                 955                 960 
Lys Glu Gly Asp Gly Ser Asn Met Asp Gln Glu Tyr Gly Thr Ala Tyr
                965                 970                 975     
Thr Pro Gln Thr His Thr Ser Cys Gly Met Pro Pro Ser Ser Ala Pro
            980                 985                 990         
Pro Ser Asn Ser Gly Ala Gly Ile Leu Pro Ser Pro Ser Thr Pro Arg
        995                 1000                1005            
Phe Pro Thr Pro Arg Thr Pro Arg Thr Pro Arg Thr Pro Arg Gly Ala
    1010                1015                1020                
Gly Gly Pro Ala Ser Ala Gln Gly Ser Val Lys Tyr Glu Asn Ser Asp
1025                1030                1035                1040
Leu Tyr Ser Pro Ala Ser Thr Pro Ser Thr Cys Arg Pro Leu Asn Ser
                1045                1050                1055    
Val Glu Pro Ala Thr Val Pro Ser Ile Pro Glu Ala His Ser Leu Tyr
            1060                1065                1070        
Val Asn Leu Ile Leu Ser Glu Ser Val Met Asn Leu Phe Lys Asp Cys
        1075                1080                1085            
Asn Ser Asp Ser Cys Cys Ile Cys Val Cys Asn Met Asn Ile Lys Gly
    1090                1095                1100                
Ala Asp Val Gly Val Tyr Ile Pro Asp Pro Thr Gln Glu Ala Gln Tyr
1105                1110                1115                1120
Arg Cys Thr Cys Gly Phe Ser Ala Val Met Asn Arg Lys Phe Gly Asn
                1125                1130                1135    
Asn Ser Gly Leu Phe Leu Glu Asp Glu Leu Asp Ile Ile Gly Arg Asn
            1140                1145                1150        
Thr Asp Cys Gly Lys Glu Ala Glu Lys Arg Phe Glu Ala Leu Arg Ala
        1155                1160                1165            
Thr Ser Ala Glu His Val Asn Gly Gly Leu Lys Glu Ser Glu Lys Leu
    1170                1175                1180                
Ser Asp Asp Leu Ile Leu Leu Leu Gln Asp Gln Cys Thr Asn Leu Phe
1185                1190                1195                1200
Ser Pro Phe Gly Ala Ala Asp Gln Asp Pro Phe Pro Lys Ser Gly Val
                1205                1210                1215    
Ile Ser Asn Trp Val Arg Val Glu Glu Arg Asp Cys Cys Asn Asp Cys
            1220                1225                1230        
Tyr Leu Ala Leu Glu His Gly Arg Gln Phe Met Asp Asn Met Ser Gly
        1235                1240                1245            
Gly Lys Val Asp Glu Ala Leu Val Lys Ser Ser Cys Leu His Pro Trp
    1250                1255                1260                
Ser Lys Arg Asn Asp Val Ser Met Gln Cys Ser Gln Asp Ile Leu Arg
1265                1270                1275                1280
Met Leu Leu Ser Leu Gln Pro Val Leu Gln Asp Ala Ile Gln Lys Lys
                1285                1290                1295    
Arg Thr Val Arg Pro Trp Gly Val Gln Gly Pro Leu Thr Trp Gln Gln
            1300                1305                1310        
Phe His Lys Met Ala Gly Arg Gly Ser Tyr Gly Thr Asp Glu Ser Pro
        1315                1320                1325            
Glu Pro Leu Pro Ile Pro Thr Phe Leu Leu Gly Tyr Asp Tyr Asp Tyr
    1330                1335                1340                
Leu Val Leu Ser Pro Phe Ala Leu Pro Tyr Trp Glu Arg Leu Met Leu
1345                1350                1355                1360
Glu Pro Tyr Gly Ser Gln Arg Asp Ile Ala Tyr Val Val Leu Cys Pro
                1365                1370                1375    
Glu Asn Glu Ala Leu Leu Asn Gly Ala Lys Ser Phe Phe Arg Asp Leu
            1380                1385                1390        
Thr Ala Ile Tyr Glu Ser Cys Arg Leu Gly Gln His Arg Pro Val Ser
        1395                1400                1405            
Arg Leu Leu Thr Asp Gly Ile Met Arg Val Gly Ser Thr Ala Ser Lys
    1410                1415                1420                
Lys Leu Ser Glu Lys Leu Val Ala Glu Trp Phe Ser Gln Ala Ala Asp
1425                1430                1435                1440
Gly Asn Asn Glu Ala Phe Ser Lys Leu Lys Leu Tyr Ala Gln Val Cys
                1445                1450                1455    
Arg Tyr Asp Leu Gly Pro Tyr Leu Ala Ser Leu Pro Leu Asp Ser Ser
            1460                1465                1470        
Leu Leu Ser Gln Pro Asn Leu Val Ala Pro Thr Ser Gln Ser Leu Ile
        1475                1480                1485            
Thr Pro Pro Gln Met Thr Asn Thr Gly Asn Ala Asn Thr Pro Ser Ala
    1490                1495                1500                
Thr Leu Ala Ser Ala Ala Ser Ser Thr Met Thr Val Thr Ser Gly Val
1505                1510                1515                1520
Ala Ile Ser Thr Ser Val Ala Thr Ala Asn Ser Thr Leu Thr Thr Ala
                1525                1530                1535    
Ser Thr Ser Ser Ser Ser Ser Ser Asn Leu Asn Ser Gly Val Ser Ser
            1540                1545                1550        
Asn Lys Leu Pro Ser Phe Pro Pro Phe Gly Ser Met Asn Ser Asn Ala
        1555                1560                1565            
Ala Gly Ser Met Ser Thr Gln Ala Asn Thr Val Gln Ser Gly Gln Leu
    1570                1575                1580                
Gly Gly Gln Gln Thr Ser Ala Leu Gln Thr Ala Gly Ile Ser Gly Glu
1585                1590                1595                1600
Ser Ser Ser Leu Pro Thr Gln Pro His Pro Asp Val Ser Glu Ser Thr
                1605                1610                1615    
Met Asp Arg Asp Lys Val Gly Ile Pro Thr Asp Gly Asp Ser His Ala
            1620                1625                1630        
Val Thr Tyr Pro Pro Ala Ile Val Val Tyr Ile Ile Asp Pro Phe Thr
        1635                1640                1645            
Tyr Glu Asn Thr Asp Glu Ser Thr Asn Ser Ser Ser Val Trp Thr Leu
    1650                1655                1660                
Gly Leu Leu Arg Cys Phe Leu Glu Met Val Gln Thr Leu Pro Pro His
1665                1670                1675                1680
Ile Lys Ser Thr Val Ser Val Gln Ile Ile Pro Cys Gln Tyr Leu Leu
                1685                1690                1695    
Gln Pro Val Lys His Glu Asp Arg Glu Ile Tyr Pro Gln His Leu Lys
            1700                1705                1710        
Ser Leu Ala Phe Ser Ala Phe Thr Gln Cys Arg Arg Pro Leu Pro Thr
        1715                1720                1725            
Ser Thr Asn Val Lys Thr Leu Thr Gly Phe Gly Pro Gly Leu Ala Met
    1730                1735                1740                
Glu Thr Ala Leu Arg Ser Pro Asp Arg Pro Glu Cys Ile Arg Leu Tyr
1745                1750                1755                1760
Ala Pro Pro Phe Ile Leu Ala Pro Val Lys Asp Lys Gln Thr Glu Leu
                1765                1770                1775    
Gly Glu Thr Phe Gly Glu Ala Gly Gln Lys Tyr Asn Val Leu Phe Val
            1780                1785                1790        
Gly Tyr Cys Leu Ser His Asp Gln Arg Trp Ile Leu Ala Ser Cys Thr
        1795                1800                1805            
Asp Leu Tyr Gly Glu Leu Leu Glu Thr Cys Ile Ile Asn Ile Asp Val
    1810                1815                1820                
Pro Asn Arg Ala Arg Arg Lys Lys Ser Ser Ala Arg Lys Phe Gly Leu
1825                1830                1835                1840
Gln Lys Leu Trp Glu Trp Cys Leu Gly Leu Val Gln Met Ser Ser Leu
                1845                1850                1855    
Pro Trp Arg Val Val Ile Gly Arg Leu Gly Arg Ile Gly His Gly Glu
            1860                1865                1870        
Leu Lys Asp Trp Ser Cys Leu Leu Ser Arg Arg Asn Leu Gln Ser Leu
        1875                1880                1885            
Ser Lys Arg Leu Lys Asp Met Cys Arg Met Cys Gly Ile Ser Ala Ala
    1890                1895                1900                
Asp Ser Pro Ser Ile Leu Ser Ala Cys Leu Val Ala Met Glu Pro Gln
1905                1910                1915                1920
Gly Ser Phe Val Ile Met Pro Asp Ser Val Ser Thr Gly Ser Val Phe
                1925                1930                1935    
Gly Arg Ser Thr Thr Leu Asn Met Gln Thr Ser Gln Leu Asn Thr Pro
            1940                1945                1950        
Gln Asp Thr Ser Cys Thr His Ile Leu Val Phe Pro Thr Ser Ala Ser
        1955                1960                1965            
Val Gln Val Ala Ser Ala Thr Tyr Thr Thr Glu Asn Leu Asp Leu Ala
    1970                1975                1980                
Phe Asn Pro Asn Asn Asp Gly Ala Asp Gly Met Gly Ile Phe Asp Leu
1985                1990                1995                2000
Leu Asp Thr Gly Asp Asp Leu Asp Pro Asp Ile Ile Asn Ile Leu Pro
                2005                2010                2015    
Ala Ser Pro Thr Gly Ser Pro Val His Ser Pro Gly Ser His Tyr Pro
            2020                2025                2030        
His Gly Gly Asp Ala Gly Lys Gly Gln Ser Thr Asp Arg Leu Leu Ser
        2035                2040                2045            
Thr Glu Pro His Glu Glu Val Pro Asn Ile Leu Gln Gln Pro Leu Ala
    2050                2055                2060                
Leu Gly Tyr Phe Val Ser Thr Ala Lys Ala Gly Pro Leu Pro Asp Trp
2065                2070                2075                2080
Phe Trp Ser Ala Cys Pro Gln Ala Gln Tyr Gln Cys Pro Leu Phe Leu
                2085                2090                2095    
Lys Ala Ser Leu His Leu His Val Pro Ser Val Gln Ser Asp Glu Leu
            2100                2105                2110        
Leu His Ser Lys His Ser His Pro Leu Asp Ser Asn Gln Thr Ser Asp
        2115                2120                2125            
Val Leu Arg Phe Val Leu Glu Gln Tyr Asn Ala Leu Ser Trp Leu Thr
    2130                2135                2140                
Cys Asp Pro Ala Thr Gln Asp Arg Arg Ser Cys Leu Pro Ile His Phe
2145                2150                2155                2160
Val Val Leu Asn Gln Leu Tyr Asn Phe Ile Met Asn Met Leu
                2165                2170                


<210> 6170
<211> 433
<212> PRT
<213> Homo sapiens

<400> 6170
Met Pro Cys Gly Lys Gln Gly Asn Leu Gln Val Pro Gly Ser Lys Val
 1               5                  10                  15      
Leu Pro Gly Leu Gly Glu Gly Cys Lys Glu Met Trp Leu Arg Lys Val
            20                  25                  30          
Ile Tyr Gly Gly Glu Val Trp Gly Lys Ser Pro Glu Pro Glu Phe Pro
        35                  40                  45              
Ser Leu Val Asn Leu Cys Gln Ser Trp Lys Ile Asn Asn Leu Met Ser
    50                  55                  60                  
Thr Val His Ser Asp Glu Ala Gly Met Leu Ser Tyr Phe Leu Phe Glu
65                  70                  75                  80  
Glu Leu Met Arg Cys Asp Lys Asp Ser Met Pro Asp Gly Asn Leu Ser
                85                  90                  95      
Glu Glu Glu Lys Leu Phe Leu Ser Tyr Phe Pro Leu His Lys Phe Glu
            100                 105                 110         
Leu Glu Gln Asn Ile Lys Glu Leu Asn Thr Leu Ala Asp Gln Val Asp
        115                 120                 125             
Thr Thr His Glu Leu Leu Thr Lys Thr Ser Leu Val Ala Ser Ser Ser
    130                 135                 140                 
Gly Ala Val Ser Gly Val Met Asn Ile Leu Gly Leu Ala Leu Ala Pro
145                 150                 155                 160 
Val Thr Ala Gly Gly Ser Leu Met Leu Ser Ala Thr Gly Thr Gly Leu
                165                 170                 175     
Gly Ala Ala Ala Ala Ile Thr Asn Ile Val Thr Asn Val Leu Glu Asn
            180                 185                 190         
Arg Ser Asn Ser Ala Ala Arg Asp Lys Ala Ser Arg Leu Gly Pro Leu
        195                 200                 205             
Thr Thr Ser His Glu Ala Phe Gly Gly Ile Asn Trp Ser Glu Ile Glu
    210                 215                 220                 
Ala Ala Gly Phe Cys Val Asn Lys Cys Val Lys Ala Ile Gln Gly Ile
225                 230                 235                 240 
Lys Asp Leu His Ala Tyr Gln Met Ala Lys Ser Asn Ser Gly Phe Met
                245                 250                 255     
Ala Met Val Lys Asn Phe Val Ala Lys Arg His Ile Pro Phe Trp Thr
            260                 265                 270         
Ala Arg Gly Val Gln Arg Ala Phe Glu Gly Thr Thr Leu Ala Met Thr
        275                 280                 285             
Asn Gly Ala Trp Val Met Gly Ala Ala Gly Ala Gly Phe Leu Leu Met
    290                 295                 300                 
Lys Asp Met Ser Ser Phe Leu Gln Ser Trp Lys His Leu Glu Asp Gly
305                 310                 315                 320 
Ala Arg Thr Glu Thr Ala Glu Glu Leu Arg Ala Leu Ala Lys Lys Leu
                325                 330                 335     
Glu Gln Glu Leu Asp Arg Leu Thr Gln His His Arg His Leu Pro Gln
            340                 345                 350         
Lys Ala Ser Gln Thr Cys Ser Ser Ser Arg Gly Arg Ala Val Arg Gly
        355                 360                 365             
Ser Arg Val Val Lys Pro Glu Gly Ser Arg Ser Pro Leu Pro Trp Pro
    370                 375                 380                 
Val Val Glu His Gln Pro Arg Leu Gly Pro Gly Val Ala Leu Arg Thr
385                 390                 395                 400 
Pro Lys Arg Thr Val Ser Ala Pro Arg Met Leu Gly His Gln Pro Ala
                405                 410                 415     
Pro Pro Ala Pro Ala Arg Lys Gly Arg Gln Ala Pro Gly Arg His Arg
            420                 425                 430         
Gln
    


<210> 6171
<211> 527
<212> PRT
<213> Homo sapiens

<400> 6171
Met Ala Pro Glu Arg Leu Arg Ser Arg Ala Leu Ser Ala Phe Lys Leu
 1               5                  10                  15      
Arg Gly Leu Leu Leu Arg Gly Glu Ala Ile Lys Tyr Leu Thr Glu Ala
            20                  25                  30          
Leu Gln Ser Ile Ser Glu Leu Glu Leu Glu Asp Lys Leu Glu Lys Ile
        35                  40                  45              
Ile Asn Ala Val Glu Lys Gln Pro Leu Ser Ser Asn Met Ile Glu Arg
    50                  55                  60                  
Ser Val Val Glu Ala Ala Val Gln Glu Cys Ser Gln Ser Val Asp Glu
65                  70                  75                  80  
Thr Ile Glu His Val Phe Asn Ile Ile Gly Ala Phe Asp Ile Pro Arg
                85                  90                  95      
Phe Val Tyr Asn Ser Glu Arg Lys Lys Phe Leu Pro Leu Leu Met Thr
            100                 105                 110         
Asn His Pro Ala Pro Asn Leu Phe Gly Thr Pro Arg Asp Lys Ala Glu
        115                 120                 125             
Met Phe Arg Glu Arg Tyr Thr Ile Leu His Gln Arg Thr His Arg His
    130                 135                 140                 
Glu Leu Phe Thr Pro Pro Val Ile Gly Ser His Pro Asp Glu Ser Gly
145                 150                 155                 160 
Ser Lys Phe Gln Leu Lys Thr Ile Glu Thr Leu Leu Gly Ser Thr Thr
                165                 170                 175     
Lys Ile Gly Asp Ala Ile Val Leu Gly Met Ile Thr Gln Leu Lys Glu
            180                 185                 190         
Gly Lys Phe Phe Leu Glu Asp Pro Thr Gly Thr Val Gln Leu Asp Leu
        195                 200                 205             
Ser Lys Ala Gln Phe His Ser Gly Leu Tyr Thr Glu Ala Cys Phe Val
    210                 215                 220                 
Leu Ala Glu Gly Trp Phe Glu Asp Gln Val Phe His Val Asn Ala Phe
225                 230                 235                 240 
Gly Phe Pro Pro Thr Glu Pro Ser Ser Thr Thr Arg Ala Tyr Tyr Gly
                245                 250                 255     
Asn Ile Asn Phe Phe Gly Gly Pro Ser Asn Thr Ser Val Lys Thr Ser
            260                 265                 270         
Ala Lys Leu Lys Gln Leu Glu Glu Glu Asn Lys Asp Ala Met Phe Val
        275                 280                 285             
Phe Leu Ser Asp Val Trp Leu Asp Gln Val Glu Val Leu Glu Lys Leu
    290                 295                 300                 
Arg Ile Met Phe Ala Gly Tyr Ser Pro Ala Pro Pro Thr Cys Phe Ile
305                 310                 315                 320 
Leu Cys Gly Asn Phe Ser Ser Ala Pro Tyr Gly Lys Asn Gln Val Gln
                325                 330                 335     
Ala Leu Lys Asp Ser Leu Lys Thr Leu Ala Asp Ile Ile Cys Glu Tyr
            340                 345                 350         
Pro Asp Ile His Gln Ser Ser Arg Phe Val Phe Val Pro Gly Pro Glu
        355                 360                 365             
Asp Pro Gly Phe Gly Ser Ile Leu Pro Arg Pro Pro Leu Ala Glu Ser
    370                 375                 380                 
Ile Thr Asn Glu Phe Arg Gln Arg Val Pro Phe Ser Val Phe Thr Thr
385                 390                 395                 400 
Asn Pro Cys Arg Ile Gln Tyr Cys Thr Gln Glu Ile Thr Val Phe Arg
                405                 410                 415     
Glu Asp Leu Val Asn Lys Met Cys Arg Asn Cys Val Arg Phe Pro Ser
            420                 425                 430         
Ser Asn Leu Ala Ile Pro Asn His Phe Val Lys Thr Ile Leu Ser Gln
        435                 440                 445             
Gly His Leu Thr Pro Leu Pro Leu Tyr Val Cys Pro Val Tyr Trp Ala
    450                 455                 460                 
Tyr Asp Tyr Ala Leu Arg Val Tyr Pro Val Pro Asp Leu Leu Val Ile
465                 470                 475                 480 
Ala Asp Lys Tyr Asp Pro Phe Thr Thr Thr Asn Thr Glu Cys Leu Cys
                485                 490                 495     
Ile Asn Pro Gly Ser Phe Pro Arg Ser Gly Phe Ser Phe Lys Val Phe
            500                 505                 510         
Tyr Pro Ser Asn Lys Thr Val Glu Asp Ser Lys Leu Gln Gly Phe
        515                 520                 525         


<210> 6172
<211> 571
<212> PRT
<213> Homo sapiens

<400> 6172
Leu Gly Arg Arg Ser Gly Thr Pro Gly Trp Ala Gly Pro Asp Ser Ser
 1               5                  10                  15      
Arg Asp Pro Ala Pro Gln Asp Gln Thr Val Pro Leu Arg Gly Glu Ala
            20                  25                  30          
Gly Glu Glu Glu Ser Gly Leu Gly Ala Val Arg Ala Ala Leu Gln Asn
        35                  40                  45              
Gly Val Gly Ala Ala Val Asp Arg Pro Leu Arg Pro Glu Asn Cys Trp
    50                  55                  60                  
Glu Ala Val Ala Arg Gly Gly Thr Gln Met Leu Glu Glu Gly Val Leu
65                  70                  75                  80  
Pro Ser Pro Gly Pro Ala Leu Pro Gln Glu Glu Asn Thr Gly Glu Glu
                85                  90                  95      
Gly Met Ala Ala Gly Leu Leu Thr Ala Gly Pro Arg Gly Ser Thr Phe
            100                 105                 110         
Phe Ser Ser Val Thr Val Ala Phe Ala Gln Glu Arg Trp Arg Cys Leu
        115                 120                 125             
Val Ser Thr Pro Arg Asp Arg Phe Lys Glu Gly Ile Pro Gly Lys Ser
    130                 135                 140                 
Arg Ser Leu Val Leu Leu Gly Leu Pro Val Ser Gln Pro Gly Met Asn
145                 150                 155                 160 
Ser Gln Leu Glu Gln Arg Glu Gly Ala Trp Met Leu Glu Gly Glu Asp
                165                 170                 175     
Leu Arg Ser Pro Ser Pro Gly Trp Lys Ile Ile Ser Gly Ser Pro Pro
            180                 185                 190         
Glu Gln Ala Leu Ser Glu Ala Ser Phe Gln Asp Pro Cys Val Glu Met
        195                 200                 205             
Pro Pro Gly Asp Ser Asp His Gly Thr Ser Asp Leu Glu Lys Ser Phe
    210                 215                 220                 
Asn Leu Arg Pro Val Leu Ser Pro Gln Gln Arg Val Pro Val Glu Ala
225                 230                 235                 240 
Arg Pro Arg Lys Cys Glu Thr His Thr Glu Ser Phe Lys Asn Ser Glu
                245                 250                 255     
Ile Leu Lys Pro His Arg Ala Lys Pro Tyr Ala Cys Asn Glu Cys Gly
            260                 265                 270         
Lys Ala Phe Ser Tyr Cys Ser Ser Leu Ser Gln His Gln Lys Ser His
        275                 280                 285             
Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser
    290                 295                 300                 
Gln Ser Ser Ser Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys
305                 310                 315                 320 
Pro Tyr Lys Cys Ser Glu Cys Gly Arg Ala Phe Ser Gln Asn Ala Asn
                325                 330                 335     
Leu Thr Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Arg Cys
            340                 345                 350         
Ser Glu Cys Glu Lys Ala Phe Ser Asp Cys Ser Ala Leu Val Gln His
        355                 360                 365             
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Asp Cys Gly
    370                 375                 380                 
Lys Ala Phe Arg His Ser Ala Asn Leu Thr Asn His Gln Arg Thr His
385                 390                 395                 400 
Thr Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser
                405                 410                 415     
Tyr Cys Ala Ala Phe Ile Gln His Gln Arg Ile His Thr Gly Glu Lys
            420                 425                 430         
Pro Tyr Arg Cys Ala Ala Cys Gly Lys Ala Phe Ser Gln Ser Ala Asn
        435                 440                 445             
Leu Thr Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys
    450                 455                 460                 
Ser Glu Cys Gly Lys Ala Phe Ser Gln Ser Thr Asn Leu Ile Ile His
465                 470                 475                 480 
Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly
                485                 490                 495     
Lys Phe Phe Ser Glu Ser Ser Ala Leu Ile Arg His His Ile Ile His
            500                 505                 510         
Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Asn
        515                 520                 525             
Gln Ser Ser Ser Leu Ser Gln His Gln Arg Ile His Thr Gly Val Lys
    530                 535                 540                 
Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Arg Cys Ser Ser Ala
545                 550                 555                 560 
Phe Val Arg His Gln Arg Leu His Ala Gly Glu
                565                 570     


<210> 6173
<211> 478
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 158, 227, 255, 276, 382, 446
<223> Xaa = Any Amino Acid

<400> 6173
Met Gly Ser Ala Leu Thr Ala Met Phe Leu Ser Gly Lys Pro His Leu
 1               5                  10                  15      
Val Ser Lys Phe Ser Ser Gln Ala Glu His Gly Ser Leu Ser Ile Ser
            20                  25                  30          
Pro Arg His Leu Trp Asp Ser Asp Thr Glu Ser Arg Ser His Thr Pro
        35                  40                  45              
Lys Ala Leu Leu Asn Pro Gly Gly Ser Met Gly Leu Lys Thr Glu Thr
    50                  55                  60                  
Gly Asn Asp Ala Lys Gly Gly Ile Pro Ile Tyr Ser Phe Asp Leu Arg
65                  70                  75                  80  
Gly Pro Glu Thr Lys Glu Cys Asn Ser Ala Asp His Ile Lys Phe Gln
                85                  90                  95      
Asp Ser Gln His Thr Thr His Leu Met Ile Pro Ser Asn Ser Val Ala
            100                 105                 110         
His Ser Ser Ser Ile Pro Ser His Ser Gln Thr Ile Ala Gln Ser Pro
        115                 120                 125             
His Leu Leu Gly Arg His Gln Pro Lys Trp Cys Met Cys Val Gln Ala
    130                 135                 140                 
Ala Glu Ala Val Leu Lys Gly Met Leu Gly Ser Glu Met Xaa Gly Gln
145                 150                 155                 160 
Asn Val Ser Asn Pro Ala Pro Ser Pro Ser Leu Ser Gly Val Ser Trp
                165                 170                 175     
Pro Asp Asn Val Pro Lys Ile Pro Asp Asp Gly Asn Phe Ser Leu Gly
            180                 185                 190         
Lys Glu Val Phe Gly Val Leu Gly Lys Thr Ala Pro Leu Pro Cys Gly
        195                 200                 205             
Glu His Pro Gln Gln Glu Asp Asp Met Gly Phe Arg Ser Phe Phe Pro
    210                 215                 220                 
Ile Ser Xaa Gly Pro Asn Cys Asn Arg Val Trp Gln Asn Leu Ser Glu
225                 230                 235                 240 
Pro Ile Arg Pro Asn Arg Arg Thr Asn Ser Gln Leu Ser His Xaa Pro
                245                 250                 255     
Pro Leu Pro Phe Asn Pro Ser Arg Asn Pro Ile Ser Leu Asn Thr Ala
            260                 265                 270         
Ser Ala Val Xaa His Gly Leu Arg Gln Gly Pro Leu Asn Lys Ser Gly
        275                 280                 285             
Ala Cys Ser Gln Val Cys Ser Leu Asp Val Asn Ser Leu Lys Ser Pro
    290                 295                 300                 
Thr Leu His Ser Pro Val Gln Ser Thr Ile Trp Asp Leu Pro Ser Gly
305                 310                 315                 320 
Asn Leu Lys Phe Pro Gln Val Pro Ser Tyr Leu Val Gly Leu Met Ala
                325                 330                 335     
Asn Pro Asp Ala Val Ala Ser Ile Lys Leu His His Leu Glu Leu Val
            340                 345                 350         
Val Asn Ser Asn Glu Asn Ala Pro Pro Thr Pro Ser Pro Asn Leu Ser
        355                 360                 365             
Leu Ile Lys Asn Met Pro Gly Ile Gly Ile Asn Asn Thr Xaa Asn Leu
    370                 375                 380                 
Gln Ile Leu Asp Pro Asp Ser Met Ile Pro Met Thr Thr Leu Gln Leu
385                 390                 395                 400 
Ser Gly Asn Asn Leu Ala Thr Ser His Ser Asn Leu Thr Pro Phe Leu
                405                 410                 415     
Asn Ala Thr Glu Pro Ser Ile Leu Pro His Ser Ala Pro Met Gly Pro
            420                 425                 430         
Ala Leu Met Ser His Asn Pro Met Ile Ser His Glu Ser Xaa Glu Pro
        435                 440                 445             
Trp Leu Met Ser Asn Gln Thr Val Asn Tyr Phe Pro Gln Gly Lys Ile
    450                 455                 460                 
Ser Gly His Lys Gln Cys Gln Gly Phe Cys Arg Trp Arg Arg
465                 470                 475             


<210> 6174
<211> 1131
<212> PRT
<213> Homo sapiens

<400> 6174
Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys
 1               5                  10                  15      
Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala
            20                  25                  30          
Arg Ala Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His
        35                  40                  45              
Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu
    50                  55                  60                  
Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys
65                  70                  75                  80  
Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln
                85                  90                  95      
Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu
            100                 105                 110         
Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile
        115                 120                 125             
Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp
    130                 135                 140                 
Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly
145                 150                 155                 160 
Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu
                165                 170                 175     
Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala
            180                 185                 190         
Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val
        195                 200                 205             
Thr Arg Arg Ala Ile Arg Arg Thr Val Arg Arg Ala Leu Pro Arg Val
    210                 215                 220                 
Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met
225                 230                 235                 240 
Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val
                245                 250                 255     
Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg
            260                 265                 270         
Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val
        275                 280                 285             
Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys
    290                 295                 300                 
Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val
305                 310                 315                 320 
Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro
                325                 330                 335     
Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr
            340                 345                 350         
Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu
        355                 360                 365             
Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe
    370                 375                 380                 
Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val
385                 390                 395                 400 
Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys
                405                 410                 415     
Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg
            420                 425                 430         
Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser
        435                 440                 445             
Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val
    450                 455                 460                 
Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys
465                 470                 475                 480 
Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr
                485                 490                 495     
Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr
            500                 505                 510         
Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly
        515                 520                 525             
His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val
    530                 535                 540                 
Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala
545                 550                 555                 560 
Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met
                565                 570                 575     
Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met
            580                 585                 590         
Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile
        595                 600                 605             
Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys
    610                 615                 620                 
Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp
625                 630                 635                 640 
Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala
                645                 650                 655     
Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro
            660                 665                 670         
Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile
        675                 680                 685             
Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu
    690                 695                 700                 
Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser
705                 710                 715                 720 
Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln
                725                 730                 735     
Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu
            740                 745                 750         
Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro
        755                 760                 765             
Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp
    770                 775                 780                 
Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp
785                 790                 795                 800 
Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile
                805                 810                 815     
Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn
            820                 825                 830         
Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Ala His Asn Thr
        835                 840                 845             
Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln
    850                 855                 860                 
Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser
865                 870                 875                 880 
Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Pro
                885                 890                 895     
Glu Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp
            900                 905                 910         
Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu
        915                 920                 925             
Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg
    930                 935                 940                 
Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu
945                 950                 955                 960 
Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu
                965                 970                 975     
Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe
            980                 985                 990         
Trp Tyr Ala Pro Glu Ser Leu Ser Asp Asn Ile Phe Ser Arg Gln Ser
        995                 1000                1005            
Asp Val Trp Ser Phe Gly Val Val Leu Tyr Glu Leu Phe Thr Tyr Cys
    1010                1015                1020                
Asp Lys Ser Cys Ser Pro Ser Ala Glu Phe Leu Arg Met Met Gly Cys
1025                1030                1035                1040
Glu Arg Asp Val Pro Ala Leu Cys Arg Leu Leu Glu Leu Leu Glu Glu
                1045                1050                1055    
Gly Gln Arg Leu Pro Ala Pro Pro Ala Cys Pro Ala Glu Val Ser Cys
            1060                1065                1070        
Tyr Ser Gly Trp Arg Asp Asp Ile Cys Ser Met Gly Trp Trp Pro Thr
        1075                1080                1085            
Val Ile Ser Arg Trp Asp Leu Ala Cys Ser Pro Cys Pro Arg Pro Leu
    1090                1095                1100                
Thr Ile Thr Ala Thr Thr Val Gln Leu Pro Pro Thr Leu His Ala Thr
1105                1110                1115                1120
Ala Ala Ser Val Ala Val Pro Asn Lys Thr Cys
                1125                1130    


<210> 6175
<211> 2191
<212> PRT
<213> Homo sapiens

<400> 6175
Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Thr Val Gly Glu
 1               5                  10                  15      
Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His His Ala
            20                  25                  30          
His His His His His His Ala His His Leu His His His His Ala Leu
        35                  40                  45              
Gln Gln Gln Leu Asn Gln Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln
    50                  55                  60                  
Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Ile Ser Asn Asn Asn
65                  70                  75                  80  
Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro Gly Pro Asp Met
                85                  90                  95      
Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln
            100                 105                 110         
Ala Asp Pro Pro Gly Pro Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp
        115                 120                 125             
Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Gly Arg Tyr Glu His
    130                 135                 140                 
Pro Gly Leu Gly Ala Leu Gly Thr Gln Gln Pro Pro Val Ala Val Pro
145                 150                 155                 160 
Gly Gly Gly Gly Gly Pro Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr
                165                 170                 175     
Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro
            180                 185                 190         
Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met Gly Met Met
        195                 200                 205             
His Ser Ala Ser Ala Ala Ala Ala Gly Ala Pro Gly Ser Met Asp Pro
    210                 215                 220                 
Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr
225                 230                 235                 240 
Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly
                245                 250                 255     
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly
            260                 265                 270         
Ala Gly Gly Ala Gly Ala Gly Ala Val Ala Ala Ala Ala Ala Ala Ala
        275                 280                 285             
Ala Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser
    290                 295                 300                 
Ala Gly Tyr Gly Val Leu Ser Ser Pro Arg Gln Gln Gly Gly Gly Met
305                 310                 315                 320 
Met Met Gly Pro Gly Gly Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala
                325                 330                 335     
Ala Gly Ser Ala Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln
            340                 345                 350         
His Pro Ser Gly Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro
        355                 360                 365             
Ser Pro Met Met Arg Ser Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser
    370                 375                 380                 
Pro Ser Ala Pro Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala
385                 390                 395                 400 
Ala Ala Gly Ala Ala Ala Gly Gly Gln Gln Ala Ala Ala Gly Met Gly
                405                 410                 415     
Leu Gly Lys Asp Met Gly Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp
            420                 425                 430         
Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro
        435                 440                 445             
Gly Pro Thr Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val
    450                 455                 460                 
Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln
465                 470                 475                 480 
Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly
                485                 490                 495     
Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met
            500                 505                 510         
Ala Gly Met Gln Tyr Pro Gln Gln Gln Asp Ser Gly Asp Ala Thr Trp
        515                 520                 525             
Lys Glu Thr Phe Trp Leu Met Pro Pro Gln Tyr Gly Gln Gln Gly Val
    530                 535                 540                 
Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro
545                 550                 555                 560 
Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser
                565                 570                 575     
Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly
            580                 585                 590         
Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp
        595                 600                 605             
Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser
    610                 615                 620                 
Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser
625                 630                 635                 640 
Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn
                645                 650                 655     
Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser
            660                 665                 670         
Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser
        675                 680                 685             
Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser
    690                 695                 700                 
Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His
705                 710                 715                 720 
Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala
                725                 730                 735     
Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr
            740                 745                 750         
Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala
        755                 760                 765             
Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro
    770                 775                 780                 
Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala
785                 790                 795                 800 
Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met
                805                 810                 815     
Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro
            820                 825                 830         
Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn
        835                 840                 845             
Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly
    850                 855                 860                 
Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val
865                 870                 875                 880 
Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala
                885                 890                 895     
Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser
            900                 905                 910         
Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser
        915                 920                 925             
Ser Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala
    930                 935                 940                 
Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp Met Met Ser
945                 950                 955                 960 
Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu
                965                 970                 975     
Glu Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Lys Ser Ser Ser Ser
            980                 985                 990         
Thr Thr Thr Gly Glu Lys Ile Thr Lys Val Tyr Glu Leu Gly Asn Glu
        995                 1000                1005            
Pro Glu Arg Lys Leu Trp Val Asp Arg Tyr Leu Thr Phe Met Glu Glu
    1010                1015                1020                
Arg Gly Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu
1025                1030                1035                1040
Asp Leu Phe Arg Leu Tyr Val Cys Val Lys Glu Ile Gly Gly Leu Ala
                1045                1050                1055    
Gln Val Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Thr Asn Leu Asn
            1060                1065                1070        
Val Gly Thr Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile
        1075                1080                1085            
Gln Tyr Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Glu Pro
    1090                1095                1100                
Pro Pro Glu Val Phe Ser Thr Gly Asp Thr Lys Lys Gln Pro Lys Leu
1105                1110                1115                1120
Gln Pro Pro Ser Pro Ala Asn Ser Gly Ser Leu Gln Gly Pro Gln Thr
                1125                1130                1135    
Pro Gln Ser Thr Gly Ser Asn Ser Met Ala Glu Val Pro Gly Asp Leu
            1140                1145                1150        
Lys Pro Pro Thr Pro Ala Ser Thr Pro His Gly Gln Met Thr Pro Met
        1155                1160                1165            
Gln Gly Gly Arg Ser Ser Thr Ile Ser Val His Asp Pro Phe Ser Asp
    1170                1175                1180                
Val Ser Asp Ser Ser Phe Pro Lys Arg Asn Ser Met Thr Pro Asn Ala
1185                1190                1195                1200
Pro Tyr Gln Gln Gly Met Ser Met Pro Asp Val Met Gly Arg Met Pro
                1205                1210                1215    
Tyr Glu Pro Asn Lys Asp Pro Phe Gly Gly Met Arg Lys Val Pro Gly
            1220                1225                1230        
Ser Ser Glu Pro Phe Met Thr Gln Gly Gln Met Pro Asn Ser Ser Met
        1235                1240                1245            
Gln Asp Met Tyr Asn Gln Ser Pro Ser Gly Ala Met Ser Asn Leu Gly
    1250                1255                1260                
Met Gly Gln Arg Gln Gln Phe Pro Tyr Gly Ala Ser Tyr Asp Arg Arg
1265                1270                1275                1280
His Glu Pro Tyr Gly Gln Gln Tyr Pro Gly Gln Gly Pro Pro Ser Gly
                1285                1290                1295    
Gln Pro Pro Tyr Gly Gly His Gln Pro Gly Leu Tyr Pro Gln Gln Pro
            1300                1305                1310        
Asn Tyr Lys Arg His Met Asp Gly Met Tyr Gly Pro Pro Ala Lys Arg
        1315                1320                1325            
His Glu Gly Asp Met Tyr Asn Met Gln Tyr Ser Ser Gln Gln Gln Glu
    1330                1335                1340                
Met Tyr Asn Gln Tyr Gly Gly Ser Tyr Ser Gly Pro Asp Arg Arg Pro
1345                1350                1355                1360
Ile Gln Gly Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg Met Gln Gly
                1365                1370                1375    
Pro Gly Gln Ile Gln Thr His Gly Ile Pro Pro Gln Met Met Gly Gly
            1380                1385                1390        
Pro Leu Gln Ser Ser Ser Ser Glu Gly Pro Gln Gln Asn Met Trp Ala
        1395                1400                1405            
Ala Arg Asn Asp Met Pro Tyr Pro Tyr Gln Asn Arg Gln Gly Pro Gly
    1410                1415                1420                
Gly Pro Thr Gln Ala Pro Pro Tyr Pro Gly Met Asn Arg Thr Asp Asp
1425                1430                1435                1440
Met Met Val Pro Asp Gln Arg Ile Asn His Glu Ser Gln Trp Pro Ser
                1445                1450                1455    
His Val Ser Gln Arg Gln Pro Tyr Met Ser Ser Ser Ala Ser Met Gln
            1460                1465                1470        
Pro Ile Thr Arg Pro Pro Gln Pro Ser Tyr Gln Thr Pro Pro Ser Leu
        1475                1480                1485            
Pro Asn His Ile Ser Arg Ala Pro Ser Pro Ala Ser Phe Gln Arg Ser
    1490                1495                1500                
Leu Glu Asn Arg Met Ser Pro Ser Lys Ser Pro Phe Leu Pro Ser Met
1505                1510                1515                1520
Lys Met Gln Lys Val Met Pro Thr Val Pro Thr Ser Gln Val Thr Gly
                1525                1530                1535    
Pro Pro Pro Gln Pro Pro Pro Ile Arg Arg Glu Ile Thr Phe Pro Pro
            1540                1545                1550        
Gly Ser Val Glu Ala Ser Gln Pro Val Leu Lys Gln Arg Arg Lys Ile
        1555                1560                1565            
Thr Ser Lys Asp Ile Val Thr Pro Glu Ala Trp Arg Val Met Met Ser
    1570                1575                1580                
Leu Lys Ser Gly Leu Leu Ala Glu Ser Thr Trp Ala Leu Asp Thr Ile
1585                1590                1595                1600
Asn Ile Leu Leu Tyr Asp Asp Ser Thr Val Ala Thr Phe Asn Leu Ser
                1605                1610                1615    
Gln Leu Ser Gly Phe Leu Glu Leu Leu Val Glu Tyr Phe Arg Lys Cys
            1620                1625                1630        
Leu Ile Asp Ile Phe Gly Ile Leu Met Glu Tyr Glu Val Gly Asp Pro
        1635                1640                1645            
Ser Gln Lys Ala Leu Asp His Asn Ala Ala Arg Lys Asp Asp Ser Gln
    1650                1655                1660                
Ser Leu Ala Asp Asp Ser Gly Lys Glu Glu Glu Asp Ala Glu Cys Ile
1665                1670                1675                1680
Asp Asp Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Asp Ser Glu Lys
                1685                1690                1695    
Thr Glu Ser Asp Glu Lys Ser Ser Ile Ala Leu Thr Ala Pro Asp Ala
            1700                1705                1710        
Ala Ala Asp Pro Lys Glu Lys Pro Lys Gln Ala Ser Lys Phe Asp Lys
        1715                1720                1725            
Leu Pro Ile Lys Ile Val Lys Lys Asn Asn Leu Phe Val Val Asp Arg
    1730                1735                1740                
Ser Asp Lys Leu Gly Arg Val Gln Glu Phe Asn Ser Gly Leu Leu His
1745                1750                1755                1760
Trp Gln Leu Gly Gly Gly Asp Thr Thr Glu His Ile Gln Thr His Phe
                1765                1770                1775    
Glu Ser Lys Met Glu Ile Pro Pro Arg Arg Arg Pro Pro Pro Pro Leu
            1780                1785                1790        
Ser Ser Ala Gly Arg Lys Lys Glu Gln Glu Gly Lys Gly Asp Ser Glu
        1795                1800                1805            
Glu Gln Gln Glu Lys Ser Ile Ile Ala Thr Ile Asp Asp Val Leu Ser
    1810                1815                1820                
Ala Arg Pro Gly Ala Leu Pro Glu Asp Ala Asn Pro Gly Pro Gln Thr
1825                1830                1835                1840
Glu Ser Ser Lys Phe Pro Phe Gly Ile Gln Gln Ala Lys Ser His Arg
                1845                1850                1855    
Asn Ile Lys Leu Leu Glu Asp Glu Pro Arg Ser Arg Asp Glu Thr Pro
            1860                1865                1870        
Leu Cys Thr Ile Ala His Trp Gln Asp Ser Leu Ala Lys Arg Cys Ile
        1875                1880                1885            
Cys Val Ser Asn Ile Val Arg Ser Leu Ser Phe Val Pro Gly Asn Asp
    1890                1895                1900                
Ala Glu Met Ser Lys His Pro Gly Leu Val Leu Ile Leu Gly Lys Leu
1905                1910                1915                1920
Ile Leu Leu His His Glu His Pro Glu Arg Lys Arg Ala Pro Gln Thr
                1925                1930                1935    
Tyr Glu Lys Glu Glu Asp Glu Asp Lys Gly Val Ala Cys Ser Lys Asp
            1940                1945                1950        
Glu Trp Trp Trp Asp Cys Leu Glu Val Leu Arg Asp Asn Thr Leu Val
        1955                1960                1965            
Thr Leu Ala Asn Ile Ser Gly Gln Leu Asp Leu Ser Ala Tyr Thr Glu
    1970                1975                1980                
Ser Ile Cys Leu Pro Ile Leu Asp Gly Leu Leu His Trp Met Val Cys
1985                1990                1995                2000
Pro Ser Ala Glu Ala Gln Asp Pro Phe Pro Thr Val Gly Pro Asn Ser
                2005                2010                2015    
Val Leu Ser Pro Gln Arg Leu Val Leu Glu Thr Leu Cys Lys Leu Ser
            2020                2025                2030        
Ile Gln Asp Asn Asn Val Asp Leu Ile Leu Ala Thr Pro Pro Phe Ser
        2035                2040                2045            
Arg Gln Glu Lys Phe Tyr Ala Thr Leu Val Arg Tyr Val Gly Asp Arg
    2050                2055                2060                
Lys Asn Pro Val Cys Arg Glu Met Ser Met Ala Leu Leu Ser Asn Leu
2065                2070                2075                2080
Ala Gln Gly Asp Ala Leu Ala Ala Arg Ala Ile Ala Val Gln Lys Gly
                2085                2090                2095    
Ser Ile Gly Asn Leu Ile Ser Phe Leu Glu Asp Gly Val Thr Met Ala
            2100                2105                2110        
Gln Tyr Gln Gln Ser Gln His Asn Leu Met His Met Gln Pro Pro Pro
        2115                2120                2125            
Leu Glu Pro Pro Ser Val Asp Met Met Cys Arg Ala Ala Lys Ala Leu
    2130                2135                2140                
Leu Ala Met Ala Arg Val Asp Glu Asn Arg Ser Glu Phe Leu Leu His
2145                2150                2155                2160
Glu Gly Arg Leu Leu Asp Ile Ser Ile Ser Ala Val Leu Asn Ser Leu
                2165                2170                2175    
Val Ala Ser Val Ile Cys Asp Val Leu Phe Gln Ile Gly Gln Leu
            2180                2185                2190    


<210> 6176
<211> 2178
<212> PRT
<213> Homo sapiens

<400> 6176
Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Thr Val Gly Glu
 1               5                  10                  15      
Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His His Ala
            20                  25                  30          
His His His His His His Ala His His Leu His His His His Ala Leu
        35                  40                  45              
Gln Gln Gln Leu Asn Gln Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln
    50                  55                  60                  
Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Ile Ser Asn Asn Asn
65                  70                  75                  80  
Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro Gly Pro Asp Met
                85                  90                  95      
Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln
            100                 105                 110         
Ala Asp Pro Pro Gly Pro Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp
        115                 120                 125             
Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Gly Arg Tyr Glu His
    130                 135                 140                 
Pro Gly Leu Gly Ala Leu Gly Thr Gln Gln Pro Pro Val Ala Val Pro
145                 150                 155                 160 
Gly Gly Gly Gly Gly Pro Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr
                165                 170                 175     
Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro
            180                 185                 190         
Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met Gly Met Met
        195                 200                 205             
His Ser Ala Ser Ala Ala Ala Ala Gly Ala Pro Gly Ser Met Asp Pro
    210                 215                 220                 
Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr
225                 230                 235                 240 
Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly
                245                 250                 255     
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly
            260                 265                 270         
Ala Gly Gly Ala Gly Ala Gly Ala Val Ala Ala Ala Ala Ala Ala Ala
        275                 280                 285             
Ala Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser
    290                 295                 300                 
Ala Gly Tyr Gly Val Leu Ser Ser Pro Arg Gln Gln Gly Gly Gly Met
305                 310                 315                 320 
Met Met Gly Pro Gly Gly Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala
                325                 330                 335     
Ala Gly Ser Ala Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln
            340                 345                 350         
His Pro Ser Gly Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro
        355                 360                 365             
Ser Pro Met Met Arg Ser Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser
    370                 375                 380                 
Pro Ser Ala Pro Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala
385                 390                 395                 400 
Ala Ala Gly Ala Ala Ala Gly Gly Gln Gln Ala Ala Ala Gly Met Gly
                405                 410                 415     
Leu Gly Lys Asp Met Gly Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp
            420                 425                 430         
Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro
        435                 440                 445             
Gly Pro Thr Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val
    450                 455                 460                 
Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln
465                 470                 475                 480 
Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly
                485                 490                 495     
Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met
            500                 505                 510         
Ala Gly Met Gln Tyr Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln
        515                 520                 525             
Gln Gly Val Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser
    530                 535                 540                 
Gln Gln Pro Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro
545                 550                 555                 560 
Ser Gln Ser Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu
                565                 570                 575     
Gly Tyr Gly Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn
            580                 585                 590         
His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro
        595                 600                 605             
Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr
    610                 615                 620                 
Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp
625                 630                 635                 640 
Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His
                645                 650                 655     
Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro
            660                 665                 670         
Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile
        675                 680                 685             
Pro Gly Ser Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser
    690                 695                 700                 
Ser Ser His Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly
705                 710                 715                 720 
Phe Met Ala Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro
                725                 730                 735     
Gln Gln Thr Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln
            740                 745                 750         
Met His Ala Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr
        755                 760                 765             
Tyr Gly Pro Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg
    770                 775                 780                 
Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly
785                 790                 795                 800 
Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro
                805                 810                 815     
Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly
            820                 825                 830         
Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser
        835                 840                 845             
Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met
    850                 855                 860                 
Pro Thr Val Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln
865                 870                 875                 880 
Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met
                885                 890                 895     
Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met
            900                 905                 910         
Asn Asn Ser Ser Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met
        915                 920                 925             
Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp
    930                 935                 940                 
Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp
945                 950                 955                 960 
Gly Lys Glu Glu Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Lys Ser
                965                 970                 975     
Ser Ser Ser Thr Thr Thr Gly Glu Lys Ile Thr Lys Val Tyr Glu Leu
            980                 985                 990         
Gly Asn Glu Pro Glu Arg Lys Leu Trp Val Asp Arg Tyr Leu Thr Phe
        995                 1000                1005            
Met Glu Glu Arg Gly Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys
    1010                1015                1020                
Lys Pro Leu Asp Leu Phe Arg Leu Tyr Val Cys Val Lys Glu Ile Gly
1025                1030                1035                1040
Gly Leu Ala Gln Val Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Thr
                1045                1050                1055    
Asn Leu Asn Val Gly Thr Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys
            1060                1065                1070        
Gln Tyr Ile Gln Tyr Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly
        1075                1080                1085            
Glu Glu Pro Pro Pro Glu Val Phe Ser Thr Gly Asp Thr Lys Lys Gln
    1090                1095                1100                
Pro Lys Leu Gln Pro Pro Ser Pro Ala Asn Ser Gly Ser Leu Gln Gly
1105                1110                1115                1120
Pro Gln Thr Pro Gln Ser Thr Gly Ser Asn Ser Met Ala Glu Val Pro
                1125                1130                1135    
Gly Asp Leu Lys Pro Pro Thr Pro Ala Ser Thr Pro His Gly Gln Met
            1140                1145                1150        
Thr Pro Met Gln Gly Gly Arg Ser Ser Thr Ile Ser Val His Asp Pro
        1155                1160                1165            
Phe Ser Asp Val Ser Asp Ser Ser Phe Pro Lys Arg Asn Ser Met Thr
    1170                1175                1180                
Pro Asn Ala Pro Tyr Gln Gln Gly Met Ser Met Pro Asp Val Met Gly
1185                1190                1195                1200
Arg Met Pro Tyr Glu Pro Asn Lys Asp Pro Phe Gly Gly Met Arg Lys
                1205                1210                1215    
Val Pro Gly Ser Ser Glu Pro Phe Met Thr Gln Gly Gln Met Pro Asn
            1220                1225                1230        
Ser Ser Met Gln Asp Met Tyr Asn Gln Ser Pro Ser Gly Ala Met Ser
        1235                1240                1245            
Asn Leu Gly Met Gly Gln Arg Gln Gln Phe Pro Tyr Gly Ala Ser Tyr
    1250                1255                1260                
Asp Arg Arg His Glu Pro Tyr Gly Gln Gln Tyr Pro Gly Gln Gly Pro
1265                1270                1275                1280
Pro Ser Gly Gln Pro Pro Tyr Gly Gly His Gln Pro Gly Leu Tyr Pro
                1285                1290                1295    
Gln Gln Pro Asn Tyr Lys Arg His Met Asp Gly Met Tyr Gly Pro Pro
            1300                1305                1310        
Ala Lys Arg His Glu Gly Asp Met Tyr Asn Met Gln Tyr Ser Ser Gln
        1315                1320                1325            
Gln Gln Glu Met Tyr Asn Gln Tyr Gly Gly Ser Tyr Ser Gly Pro Asp
    1330                1335                1340                
Arg Arg Pro Ile Gln Gly Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg
1345                1350                1355                1360
Met Gln Gly Pro Gly Gln Ile Gln Thr His Gly Ile Pro Pro Gln Met
                1365                1370                1375    
Met Gly Gly Pro Leu Gln Ser Ser Ser Ser Glu Gly Pro Gln Gln Asn
            1380                1385                1390        
Met Trp Ala Ala Arg Asn Asp Met Pro Tyr Pro Tyr Gln Asn Arg Gln
        1395                1400                1405            
Gly Pro Gly Gly Pro Thr Gln Ala Pro Pro Tyr Pro Gly Met Asn Arg
    1410                1415                1420                
Thr Asp Asp Met Met Val Pro Asp Gln Arg Ile Asn His Glu Ser Gln
1425                1430                1435                1440
Trp Pro Ser His Val Ser Gln Arg Gln Pro Tyr Met Ser Ser Ser Ala
                1445                1450                1455    
Ser Met Gln Pro Ile Thr Arg Pro Pro Gln Pro Ser Tyr Gln Thr Pro
            1460                1465                1470        
Pro Ser Leu Pro Asn His Ile Ser Arg Ala Pro Ser Pro Ala Ser Phe
        1475                1480                1485            
Gln Arg Ser Leu Glu Asn Arg Met Ser Pro Ser Lys Ser Pro Phe Leu
    1490                1495                1500                
Pro Ser Met Lys Met Gln Lys Val Met Pro Thr Val Pro Thr Ser Gln
1505                1510                1515                1520
Val Thr Gly Pro Pro Pro Gln Pro Pro Pro Ile Arg Arg Glu Ile Thr
                1525                1530                1535    
Phe Pro Pro Gly Ser Val Glu Ala Ser Gln Pro Val Leu Lys Gln Arg
            1540                1545                1550        
Arg Lys Ile Thr Ser Lys Asp Ile Val Thr Pro Glu Ala Trp Arg Val
        1555                1560                1565            
Met Met Ser Leu Lys Ser Gly Leu Leu Ala Glu Ser Thr Trp Ala Leu
    1570                1575                1580                
Asp Thr Ile Asn Ile Leu Leu Tyr Asp Asp Ser Thr Val Ala Thr Phe
1585                1590                1595                1600
Asn Leu Ser Gln Leu Ser Gly Phe Leu Glu Leu Leu Val Glu Tyr Phe
                1605                1610                1615    
Arg Lys Cys Leu Ile Asp Ile Phe Gly Ile Leu Met Glu Tyr Glu Val
            1620                1625                1630        
Gly Asp Pro Ser Gln Lys Ala Leu Asp His Asn Ala Ala Arg Lys Asp
        1635                1640                1645            
Asp Ser Gln Ser Leu Ala Asp Asp Ser Gly Lys Glu Glu Glu Asp Ala
    1650                1655                1660                
Glu Cys Ile Asp Asp Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Asp
1665                1670                1675                1680
Ser Glu Lys Thr Glu Ser Asp Glu Lys Ser Ser Ile Ala Leu Thr Ala
                1685                1690                1695    
Pro Asp Ala Ala Ala Asp Pro Lys Glu Lys Pro Lys Gln Ala Ser Lys
            1700                1705                1710        
Phe Asp Lys Leu Pro Ile Lys Ile Val Lys Lys Asn Asn Leu Phe Val
        1715                1720                1725            
Val Asp Arg Ser Asp Lys Leu Gly Arg Val Gln Glu Phe Asn Ser Gly
    1730                1735                1740                
Leu Leu His Trp Gln Leu Gly Gly Gly Asp Thr Thr Glu His Ile Gln
1745                1750                1755                1760
Thr His Phe Glu Ser Lys Met Glu Ile Pro Pro Arg Arg Arg Pro Pro
                1765                1770                1775    
Pro Pro Leu Ser Ser Ala Gly Arg Lys Lys Glu Gln Glu Gly Lys Gly
            1780                1785                1790        
Asp Ser Glu Glu Gln Gln Glu Lys Ser Ile Ile Ala Thr Ile Asp Asp
        1795                1800                1805            
Val Leu Ser Ala Arg Pro Gly Ala Leu Pro Glu Asp Ala Asn Pro Gly
    1810                1815                1820                
Pro Gln Thr Glu Ser Ser Lys Phe Pro Phe Gly Ile Gln Gln Ala Lys
1825                1830                1835                1840
Ser His Arg Asn Ile Lys Leu Leu Glu Asp Glu Pro Arg Ser Arg Asp
                1845                1850                1855    
Glu Thr Pro Leu Cys Thr Ile Ala His Trp Gln Asp Ser Leu Ala Lys
            1860                1865                1870        
Arg Cys Ile Cys Val Ser Asn Ile Val Arg Ser Leu Ser Phe Val Pro
        1875                1880                1885            
Gly Asn Asp Ala Glu Met Ser Lys His Pro Gly Leu Val Leu Ile Leu
    1890                1895                1900                
Gly Lys Leu Ile Leu Leu His His Glu His Pro Glu Arg Lys Arg Ala
1905                1910                1915                1920
Pro Gln Thr Tyr Glu Lys Glu Glu Asp Glu Asp Lys Gly Val Ala Cys
                1925                1930                1935    
Ser Lys Asp Glu Trp Trp Trp Asp Cys Leu Glu Val Leu Arg Asp Asn
            1940                1945                1950        
Thr Leu Val Thr Leu Ala Asn Ile Ser Gly Gln Leu Asp Leu Ser Ala
        1955                1960                1965            
Tyr Thr Glu Ser Ile Cys Leu Pro Ile Leu Asp Gly Leu Leu His Trp
    1970                1975                1980                
Met Val Cys Pro Ser Ala Glu Ala Gln Asp Pro Phe Pro Thr Val Gly
1985                1990                1995                2000
Pro Asn Ser Val Leu Ser Pro Gln Arg Leu Val Leu Glu Thr Leu Cys
                2005                2010                2015    
Lys Leu Ser Ile Gln Asp Asn Asn Val Asp Leu Ile Leu Ala Thr Pro
            2020                2025                2030        
Pro Phe Ser Arg Gln Glu Lys Phe Tyr Ala Thr Leu Val Arg Tyr Val
        2035                2040                2045            
Gly Asp Arg Lys Asn Pro Val Cys Arg Glu Met Ser Met Ala Leu Leu
    2050                2055                2060                
Ser Asn Leu Ala Gln Gly Asp Ala Leu Ala Ala Arg Ala Ile Ala Val
2065                2070                2075                2080
Gln Lys Gly Ser Ile Gly Asn Leu Ile Ser Phe Leu Glu Asp Gly Val
                2085                2090                2095    
Thr Met Ala Gln Tyr Gln Gln Ser Gln His Asn Leu Met His Met Gln
            2100                2105                2110        
Pro Pro Pro Leu Glu Pro Pro Ser Val Asp Met Met Cys Arg Ala Ala
        2115                2120                2125            
Lys Ala Leu Leu Ala Met Ala Arg Val Asp Glu Asn Arg Ser Glu Phe
    2130                2135                2140                
Leu Leu His Glu Gly Arg Leu Leu Asp Ile Ser Ile Ser Ala Val Leu
2145                2150                2155                2160
Asn Ser Leu Val Ala Ser Val Ile Cys Asp Val Leu Phe Gln Ile Gly
                2165                2170                2175    
Gln Leu
        


<210> 6177
<211> 349
<212> PRT
<213> Homo sapiens

<400> 6177
Ser Gln Glu Gly Tyr Gly Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly
 1               5                  10                  15      
Lys Pro Asn His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser
            20                  25                  30          
Ser Leu Pro Val Glu Val Leu Ala Ser Glu Asp Ala Ala Phe Gly Leu
        35                  40                  45              
Lys Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala
    50                  55                  60                  
Thr Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly
65                  70                  75                  80  
Asp Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro
                85                  90                  95      
His Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser
            100                 105                 110         
Pro Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser
        115                 120                 125             
Ile Pro Gly Ser Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu
    130                 135                 140                 
Ser Ser Ser His Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg
145                 150                 155                 160 
Gly Phe Met Ala Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly
                165                 170                 175     
Pro Gln Gln Thr Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly
            180                 185                 190         
Gln Met His Ala Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly
        195                 200                 205             
Thr Tyr Gly Pro Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser
    210                 215                 220                 
Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro
225                 230                 235                 240 
Gly Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly
                245                 250                 255     
Pro Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala
            260                 265                 270         
Gly Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro
        275                 280                 285             
Ser Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro
    290                 295                 300                 
Met Pro Thr Val Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met
305                 310                 315                 320 
Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg Tyr Ala Thr Gln Glu His
                325                 330                 335     
Ala Pro Gly Arg Tyr Ala Val Cys Leu Pro Val Thr Thr
            340                 345                 


<210> 6178
<211> 415
<212> PRT
<213> Homo sapiens

<400> 6178
Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr
 1               5                  10                  15      
Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp
            20                  25                  30          
Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His
        35                  40                  45              
Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro
    50                  55                  60                  
Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile
65                  70                  75                  80  
Pro Gly Ser Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser
                85                  90                  95      
Ser Ser His Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly
            100                 105                 110         
Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr Gly
        115                 120                 125             
Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly
    130                 135                 140                 
Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln
145                 150                 155                 160 
Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr
                165                 170                 175     
Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly
            180                 185                 190         
Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys
        195                 200                 205             
Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg
    210                 215                 220                 
Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly Met
225                 230                 235                 240 
Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn
                245                 250                 255     
Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn
            260                 265                 270         
Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly
        275                 280                 285             
Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser
    290                 295                 300                 
Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met
305                 310                 315                 320 
Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp Met Met Ser Pro
                325                 330                 335     
Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu
            340                 345                 350         
Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Asp Ser Tyr Ser Ser Gln
        355                 360                 365             
Gly Ile Ser Gln Pro Pro Thr Pro Gly Asn Leu Pro Val Pro Ser Pro
    370                 375                 380                 
Met Ser Pro Ser Ser Ala Ser Ile Ser Ser Phe His Gly Asp Glu Ser
385                 390                 395                 400 
Asp Ser Ile Ser Ser Pro Gly Trp Pro Lys Thr Pro Ser Ser Pro
                405                 410                 415 


<210> 6179
<211> 1485
<212> PRT
<213> Homo sapiens

<400> 6179
Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser Ser Phe Gln Gln
 1               5                  10                  15      
Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln Met Ser Gln Tyr Gly Pro
            20                  25                  30          
Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala
        35                  40                  45              
Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser Ala Asn Asn Gln
    50                  55                  60                  
Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala Val Pro Leu Gly
65                  70                  75                  80  
Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe Pro Gly Asn Met
                85                  90                  95      
Ser Ser Met Thr Pro Ser Ser Pro Gly Met Ser Gln Gln Gly Gly Pro
            100                 105                 110         
Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys Ala Gln Glu Ala
        115                 120                 125             
Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln
    130                 135                 140                 
Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met Ala Ser Ser Ser
145                 150                 155                 160 
Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu Met Asn Thr Gln
                165                 170                 175     
Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn Ser Ser Ala Ala
            180                 185                 190         
Ser Val Gly Leu Ala Asp Met Met Ser Pro Gly Glu Ser Lys Leu Pro
        195                 200                 205             
Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu Gly Thr Pro Gln Pro Glu
    210                 215                 220                 
Ser Lys Ser Lys Asp Ser Tyr Ser Ser Gln Gly Ile Ser Gln Pro Pro
225                 230                 235                 240 
Thr Pro Gly Asn Leu Pro Val Pro Ser Pro Met Ser Pro Ser Ser Ala
                245                 250                 255     
Ser Ile Ser Ser Phe His Gly Asp Glu Ser Asp Ser Ile Ser Ser Pro
            260                 265                 270         
Gly Trp Pro Lys Thr Pro Ser Ser Pro Lys Ser Ser Ser Ser Thr Thr
        275                 280                 285             
Thr Gly Glu Lys Ile Thr Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu
    290                 295                 300                 
Arg Lys Leu Trp Val Asp Arg Tyr Leu Thr Phe Met Glu Glu Arg Gly
305                 310                 315                 320 
Ser Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu Asp Leu
                325                 330                 335     
Phe Arg Leu Tyr Val Cys Val Lys Glu Ile Gly Gly Leu Ala Gln Val
            340                 345                 350         
Asn Lys Asn Lys Lys Trp Arg Glu Leu Ala Thr Asn Leu Asn Val Gly
        355                 360                 365             
Thr Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Tyr
    370                 375                 380                 
Leu Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Glu Pro Pro Pro
385                 390                 395                 400 
Glu Val Phe Ser Thr Gly Asp Thr Lys Lys Gln Pro Lys Leu Gln Pro
                405                 410                 415     
Pro Ser Pro Ala Asn Ser Gly Ser Leu Gln Gly Pro Gln Thr Pro Gln
            420                 425                 430         
Ser Thr Gly Ser Asn Ser Met Ala Glu Val Pro Gly Asp Leu Lys Pro
        435                 440                 445             
Pro Thr Pro Ala Ser Thr Pro His Gly Gln Met Thr Pro Met Gln Gly
    450                 455                 460                 
Gly Arg Ser Ser Thr Ile Ser Val His Asp Pro Phe Ser Asp Val Ser
465                 470                 475                 480 
Asp Ser Ser Phe Pro Lys Arg Asn Ser Met Thr Pro Asn Ala Pro Tyr
                485                 490                 495     
Gln Gln Gly Met Ser Met Pro Asp Val Met Gly Arg Met Pro Tyr Glu
            500                 505                 510         
Pro Asn Lys Asp Pro Phe Gly Gly Met Arg Lys Val Pro Gly Ser Ser
        515                 520                 525             
Glu Pro Phe Met Thr Gln Gly Gln Met Pro Asn Ser Ser Met Gln Asp
    530                 535                 540                 
Met Tyr Asn Gln Ser Pro Ser Gly Ala Met Ser Asn Leu Gly Met Gly
545                 550                 555                 560 
Gln Arg Gln Gln Phe Pro Tyr Gly Ala Ser Tyr Asp Arg Arg His Glu
                565                 570                 575     
Pro Tyr Gly Gln Gln Tyr Pro Gly Gln Gly Pro Pro Ser Gly Gln Pro
            580                 585                 590         
Pro Tyr Gly Gly His Gln Pro Gly Leu Tyr Pro Gln Gln Pro Asn Tyr
        595                 600                 605             
Lys Arg His Met Asp Gly Met Tyr Gly Pro Pro Ala Lys Arg His Glu
    610                 615                 620                 
Gly Asp Met Tyr Asn Met Gln Tyr Ser Ser Gln Gln Gln Glu Met Tyr
625                 630                 635                 640 
Asn Gln Tyr Gly Gly Ser Tyr Ser Gly Pro Asp Arg Arg Pro Ile Gln
                645                 650                 655     
Gly Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg Met Gln Gly Pro Gly
            660                 665                 670         
Gln Ile Gln Thr His Gly Ile Pro Leu Gln Met Met Gly Gly Pro Leu
        675                 680                 685             
Gln Ser Ser Ser Ser Glu Gly Pro Gln Gln Asn Met Trp Ala Ala Arg
    690                 695                 700                 
Asn Asp Met Pro Tyr Pro Tyr Gln Asn Arg Gln Gly Pro Gly Gly Pro
705                 710                 715                 720 
Thr Gln Ala Pro Pro Tyr Pro Gly Met Asn Arg Thr Asp Asp Met Met
                725                 730                 735     
Val Pro Asp Gln Arg Ile Asn His Glu Ser Gln Trp Pro Ser His Val
            740                 745                 750         
Ser Gln Arg Gln Pro Tyr Met Ser Ser Ser Ala Ser Met Gln Pro Ile
        755                 760                 765             
Thr Arg Pro Pro Gln Pro Ser Tyr Gln Thr Pro Pro Ser Leu Pro Asn
    770                 775                 780                 
His Ile Ser Arg Ala Pro Ser Pro Ala Ser Phe Gln Arg Ser Leu Glu
785                 790                 795                 800 
Asn Arg Met Ser Pro Ser Lys Ser Pro Phe Leu Pro Ser Met Lys Met
                805                 810                 815     
Gln Lys Val Met Pro Thr Val Pro Thr Ser Gln Val Thr Gly Pro Pro
            820                 825                 830         
Pro Gln Pro Pro Pro Ile Arg Arg Glu Ile Thr Phe Pro Pro Gly Ser
        835                 840                 845             
Val Glu Ala Ser Gln Pro Val Leu Lys Gln Arg Arg Lys Ile Thr Ser
    850                 855                 860                 
Lys Asp Ile Val Thr Pro Glu Ala Trp Arg Val Met Met Ser Leu Lys
865                 870                 875                 880 
Ser Gly Leu Leu Ala Glu Ser Thr Trp Ala Leu Asp Thr Ile Asn Ile
                885                 890                 895     
Leu Leu Tyr Asp Asp Ser Thr Val Ala Thr Phe Asn Leu Ser Gln Leu
            900                 905                 910         
Ser Gly Phe Leu Glu Leu Leu Val Glu Tyr Phe Arg Lys Cys Leu Ile
        915                 920                 925             
Asp Ile Phe Gly Ile Leu Met Glu Tyr Glu Val Gly Asp Pro Ser Gln
    930                 935                 940                 
Lys Ala Leu Asp His Asn Ala Ala Arg Lys Asp Asp Ser Gln Ser Leu
945                 950                 955                 960 
Ala Asp Asp Ser Gly Lys Glu Glu Glu Asp Ala Glu Cys Ile Asp Asp
                965                 970                 975     
Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Asp Ser Glu Lys Thr Glu
            980                 985                 990         
Ser Asp Glu Lys Ser Ser Ile Ala Leu Thr Ala Pro Asp Ala Ala Ala
        995                 1000                1005            
Asp Pro Lys Glu Lys Pro Lys Gln Ala Ser Lys Phe Asp Lys Leu Pro
    1010                1015                1020                
Ile Lys Ile Val Lys Lys Asn Asn Leu Phe Val Val Asp Arg Ser Asp
1025                1030                1035                1040
Lys Leu Gly Arg Val Gln Glu Phe Asn Ser Gly Leu Leu His Trp Gln
                1045                1050                1055    
Leu Gly Gly Gly Asp Thr Thr Glu His Ile Gln Thr His Phe Glu Ser
            1060                1065                1070        
Lys Met Glu Ile Pro Pro Arg Arg Arg Pro Pro Pro Pro Leu Ser Ser
        1075                1080                1085            
Ala Gly Arg Lys Lys Glu Gln Glu Gly Lys Gly Asp Ser Glu Glu Gln
    1090                1095                1100                
Gln Glu Lys Ser Ile Ile Ala Thr Ile Asp Asp Val Leu Ser Ala Arg
1105                1110                1115                1120
Pro Gly Ala Leu Pro Glu Asp Ala Asn Pro Gly Pro Gln Thr Glu Ser
                1125                1130                1135    
Ser Lys Phe Pro Phe Gly Ile Gln Gln Ala Lys Ser His Arg Asn Ile
            1140                1145                1150        
Lys Leu Leu Glu Asp Glu Pro Arg Ser Arg Asp Glu Thr Pro Leu Cys
        1155                1160                1165            
Thr Ile Ala His Trp Gln Asp Ser Leu Ala Lys Arg Cys Ile Cys Val
    1170                1175                1180                
Ser Asn Ile Val Arg Ser Leu Ser Phe Val Pro Gly Asn Asp Ala Glu
1185                1190                1195                1200
Met Ser Lys His Pro Gly Leu Val Leu Ile Leu Gly Lys Leu Ile Leu
                1205                1210                1215    
Leu His His Glu His Pro Glu Arg Lys Arg Ala Pro Gln Thr Tyr Glu
            1220                1225                1230        
Lys Glu Glu Asp Glu Asp Lys Gly Val Ala Cys Ser Lys Asp Glu Trp
        1235                1240                1245            
Trp Trp Asp Cys Leu Glu Val Leu Arg Asp Asn Thr Leu Val Thr Leu
    1250                1255                1260                
Ala Asn Ile Ser Gly Gln Leu Asp Leu Ser Ala Tyr Thr Glu Ser Ile
1265                1270                1275                1280
Cys Leu Pro Ile Leu Asp Gly Leu Leu His Trp Met Val Cys Pro Ser
                1285                1290                1295    
Ala Glu Ala Gln Asp Pro Phe Pro Thr Val Gly Pro Asn Ser Val Leu
            1300                1305                1310        
Ser Pro Gln Arg Leu Val Leu Glu Thr Leu Cys Lys Leu Ser Ile Gln
        1315                1320                1325            
Asp Asn Asn Val Asp Leu Ile Leu Ala Thr Pro Pro Phe Ser Arg Gln
    1330                1335                1340                
Glu Lys Phe Tyr Ala Thr Leu Val Arg Tyr Val Gly Asp Arg Lys Asn
1345                1350                1355                1360
Pro Val Cys Arg Glu Met Ser Met Ala Leu Leu Ser Asn Leu Ala Gln
                1365                1370                1375    
Gly Asp Ala Leu Ala Ala Arg Ala Ile Ala Val Gln Lys Gly Ser Ile
            1380                1385                1390        
Gly Asn Leu Ile Ser Phe Leu Glu Asp Gly Val Thr Met Ala Gln Tyr
        1395                1400                1405            
Gln Gln Ser Gln His Asn Leu Met His Met Gln Pro Pro Pro Leu Glu
    1410                1415                1420                
Pro Pro Ser Val Asp Met Met Cys Arg Ala Ala Lys Ala Leu Leu Ala
1425                1430                1435                1440
Met Ala Arg Val Asp Glu Asn Arg Ser Glu Phe Leu Leu His Glu Gly
                1445                1450                1455    
Arg Leu Leu Asp Ile Ser Ile Ser Ala Val Leu Asn Ser Leu Val Ala
            1460                1465                1470        
Ser Val Ile Cys Asp Val Leu Phe Gln Ile Gly Gln Leu
        1475                1480                1485


<210> 6180
<211> 2231
<212> PRT
<213> Homo sapiens

<400> 6180
Met Glu Thr Gly Leu Leu Pro Asn His Lys Leu Lys Thr Val Gly Glu
 1               5                  10                  15      
Ala Pro Ala Ala Pro Pro His Gln Gln His His His His His His Ala
            20                  25                  30          
His His His His His His Ala His His Leu His His His His Ala Leu
        35                  40                  45              
Gln Gln Gln Leu Asn Gln Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln
    50                  55                  60                  
Gln Gln Gln Gln Gln Gln Gln Gln Gln His Pro Ile Ser Asn Asn Asn
65                  70                  75                  80  
Ser Leu Gly Gly Ala Gly Gly Gly Ala Pro Gln Pro Gly Pro Asp Met
                85                  90                  95      
Glu Gln Pro Gln His Gly Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln
            100                 105                 110         
Ala Asp Pro Pro Gly Pro Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp
        115                 120                 125             
Asp Ala Pro Pro Lys Met Gly Glu Pro Ala Gly Gly Arg Tyr Glu His
    130                 135                 140                 
Pro Gly Leu Gly Ala Leu Gly Thr Gln Gln Pro Pro Val Ala Val Pro
145                 150                 155                 160 
Gly Gly Gly Gly Gly Pro Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr
                165                 170                 175     
Gly Ser Ala Ala Pro Ala Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro
            180                 185                 190         
Cys Phe Asp Gln His Gly Gly Gln Gln Ser Pro Gly Met Gly Met Met
        195                 200                 205             
His Ser Ala Ser Ala Ala Ala Ala Gly Ala Pro Gly Ser Met Asp Pro
    210                 215                 220                 
Leu Gln Asn Ser His Glu Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr
225                 230                 235                 240 
Pro Gly Tyr Ser Arg Pro Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly
                245                 250                 255     
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly
            260                 265                 270         
Ala Gly Gly Ala Gly Ala Gly Ala Val Ala Ala Ala Ala Ala Ala Ala
        275                 280                 285             
Ala Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser
    290                 295                 300                 
Ala Gly Tyr Gly Val Leu Ser Ser Pro Arg Gln Gln Gly Gly Gly Met
305                 310                 315                 320 
Met Met Gly Pro Gly Gly Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala
                325                 330                 335     
Ala Gly Ser Ala Ala Gly Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln
            340                 345                 350         
His Pro Ser Gly Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro
        355                 360                 365             
Ser Pro Met Met Arg Ser Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser
    370                 375                 380                 
Pro Ser Ala Pro Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala
385                 390                 395                 400 
Ala Ala Gly Ala Ala Ala Gly Gly Gln Gln Ala Ala Ala Gly Met Gly
                405                 410                 415     
Leu Gly Lys Asp Met Gly Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp
            420                 425                 430         
Ala Ala Ala Gln Gln Arg Ser His Pro Ala Met Ser Pro Gly Thr Pro
        435                 440                 445             
Gly Pro Thr Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val
    450                 455                 460                 
Met Lys Arg Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln
465                 470                 475                 480 
Pro Gln Gln Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly
                485                 490                 495     
Pro Gln Arg Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met
            500                 505                 510         
Ala Gly Met Gln Tyr Pro Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln
        515                 520                 525             
Gln Gly Val Ser Gly Tyr Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser
    530                 535                 540                 
Gln Gln Pro Gln Pro Pro His Leu Pro Pro Gln Ala Gln Tyr Leu Pro
545                 550                 555                 560 
Ser Gln Ser Gln Gln Arg Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu
                565                 570                 575     
Gly Tyr Gly Thr Arg Ser Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn
            580                 585                 590         
His Glu Asp Leu Asn Leu Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro
        595                 600                 605             
Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr
    610                 615                 620                 
Leu Ser Ser Ala Val Ser Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp
625                 630                 635                 640 
Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Ala Ser Pro His
                645                 650                 655     
Leu Ser Ser Ile Pro Gly Gly Pro Ser Pro Ser Pro Val Gly Ser Pro
            660                 665                 670         
Val Gly Ser Asn Gln Ser Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile
        675                 680                 685             
Pro Gly Ser Gln Met Pro Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser
    690                 695                 700                 
Ser Ser His Pro Ala Leu Ser Gln Ser Pro Met Pro Gln Glu Arg Gly
705                 710                 715                 720 
Phe Met Ala Gly Thr Gln Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro
                725                 730                 735     
Gln Gln Thr Gly Pro Ser Met Ser Pro His Pro Ser Pro Gly Gly Gln
            740                 745                 750         
Met His Ala Gly Ile Ser Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr
        755                 760                 765             
Tyr Gly Pro Gln Met Ser Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg
    770                 775                 780                 
Pro Pro Ala Tyr Ser Gly Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly
785                 790                 795                 800 
Pro Gly Met Gly Ile Ser Ala Asn Asn Gln Met His Gly Gln Gly Pro
                805                 810                 815     
Ser Gln Pro Cys Gly Ala Val Pro Leu Gly Arg Met Pro Ser Ala Gly
            820                 825                 830         
Met Gln Asn Arg Pro Phe Pro Gly Asn Met Ser Ser Met Thr Pro Ser
        835                 840                 845             
Ser Pro Gly Met Ser Gln Gln Gly Gly Pro Gly Met Gly Pro Pro Met
    850                 855                 860                 
Pro Thr Val Asn Arg Lys Ala Gln Glu Ala Ala Ala Ala Val Met Gln
865                 870                 875                 880 
Ala Ala Ala Asn Ser Ala Gln Ser Arg Gln Gly Ser Phe Pro Gly Met
                885                 890                 895     
Asn Gln Ser Gly Leu Met Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met
            900                 905                 910         
Asn Asn Ser Ser Ser Leu Met Asn Thr Gln Ala Pro Pro Tyr Ser Met
        915                 920                 925             
Ala Pro Ala Met Val Asn Ser Ser Ala Ala Ser Val Gly Leu Ala Asp
    930                 935                 940                 
Met Met Ser Pro Gly Glu Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp
945                 950                 955                 960 
Gly Lys Glu Glu Gly Thr Pro Gln Pro Glu Ser Lys Ser Lys Asp Ser
                965                 970                 975     
Tyr Ser Ser Gln Gly Ile Ser Gln Pro Pro Thr Pro Gly Asn Leu Pro
            980                 985                 990         
Val Pro Ser Pro Met Ser Pro Ser Ser Ala Ser Ile Ser Ser Phe His
        995                 1000                1005            
Gly Asp Glu Ser Asp Ser Ile Ser Ser Pro Gly Trp Pro Lys Thr Pro
    1010                1015                1020                
Ser Ser Pro Lys Ser Ser Ser Ser Thr Thr Thr Gly Glu Lys Ile Thr
1025                1030                1035                1040
Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu Arg Lys Leu Trp Val Asp
                1045                1050                1055    
Arg Tyr Leu Thr Phe Met Glu Glu Arg Gly Ser Pro Val Ser Ser Leu
            1060                1065                1070        
Pro Ala Val Gly Lys Lys Pro Leu Asp Leu Phe Arg Leu Tyr Val Cys
        1075                1080                1085            
Val Lys Glu Ile Gly Gly Leu Ala Gln Val Asn Lys Asn Lys Lys Trp
    1090                1095                1100                
Arg Glu Leu Ala Thr Asn Leu Asn Val Gly Thr Ser Ser Ser Ala Ala
1105                1110                1115                1120
Ser Ser Leu Lys Lys Gln Tyr Ile Gln Tyr Leu Phe Ala Phe Glu Cys
                1125                1130                1135    
Lys Ile Glu Arg Gly Glu Glu Pro Pro Pro Glu Val Phe Ser Thr Gly
            1140                1145                1150        
Asp Thr Lys Lys Gln Pro Lys Leu Gln Pro Pro Ser Pro Ala Asn Ser
        1155                1160                1165            
Gly Ser Leu Gln Gly Pro Gln Thr Pro Gln Ser Thr Gly Ser Asn Ser
    1170                1175                1180                
Met Ala Glu Val Pro Gly Asp Leu Lys Pro Pro Thr Pro Ala Ser Thr
1185                1190                1195                1200
Pro His Gly Gln Met Thr Pro Met Gln Gly Gly Arg Ser Ser Thr Ile
                1205                1210                1215    
Ser Val His Asp Pro Phe Ser Asp Val Ser Asp Ser Ser Phe Pro Lys
            1220                1225                1230        
Arg Asn Ser Met Thr Pro Asn Ala Pro Tyr Gln Gln Gly Met Ser Met
        1235                1240                1245            
Pro Asp Val Met Gly Arg Met Pro Tyr Glu Pro Asn Lys Asp Pro Phe
    1250                1255                1260                
Gly Gly Met Arg Lys Val Pro Gly Ser Ser Glu Pro Phe Met Thr Gln
1265                1270                1275                1280
Gly Gln Met Pro Asn Ser Ser Met Gln Asp Met Tyr Asn Gln Ser Pro
                1285                1290                1295    
Ser Gly Ala Met Ser Asn Leu Gly Met Gly Gln Arg Gln Gln Phe Pro
            1300                1305                1310        
Tyr Gly Ala Ser Tyr Asp Arg Arg His Glu Pro Tyr Gly Gln Gln Tyr
        1315                1320                1325            
Pro Gly Gln Gly Pro Pro Ser Gly Gln Pro Pro Tyr Gly Gly His Gln
    1330                1335                1340                
Pro Gly Leu Tyr Pro Gln Gln Pro Asn Tyr Lys Arg His Met Asp Gly
1345                1350                1355                1360
Met Tyr Gly Pro Pro Ala Lys Arg His Glu Gly Asp Met Tyr Asn Met
                1365                1370                1375    
Gln Tyr Ser Ser Gln Gln Gln Glu Met Tyr Asn Gln Tyr Gly Gly Ser
            1380                1385                1390        
Tyr Ser Gly Pro Asp Arg Arg Pro Ile Gln Gly Gln Tyr Pro Tyr Pro
        1395                1400                1405            
Tyr Ser Arg Glu Arg Met Gln Gly Pro Gly Gln Ile Gln Thr His Gly
    1410                1415                1420                
Ile Pro Pro Gln Met Met Gly Gly Pro Leu Gln Ser Ser Ser Ser Glu
1425                1430                1435                1440
Gly Pro Gln Gln Asn Met Trp Ala Ala Arg Asn Asp Met Pro Tyr Pro
                1445                1450                1455    
Tyr Gln Asn Arg Gln Gly Pro Gly Gly Pro Thr Gln Ala Pro Pro Tyr
            1460                1465                1470        
Pro Gly Met Asn Arg Thr Asp Asp Met Met Val Pro Asp Gln Arg Ile
        1475                1480                1485            
Asn His Glu Ser Gln Trp Pro Ser His Val Ser Gln Arg Gln Pro Tyr
    1490                1495                1500                
Met Ser Ser Ser Ala Ser Met Gln Pro Ile Thr Arg Pro Pro Gln Pro
1505                1510                1515                1520
Ser Tyr Gln Thr Pro Pro Ser Leu Pro Asn His Ile Ser Arg Ala Pro
                1525                1530                1535    
Ser Pro Ala Ser Phe Gln Arg Ser Leu Glu Asn Arg Met Ser Pro Ser
            1540                1545                1550        
Lys Ser Pro Phe Leu Pro Ser Met Lys Met Gln Lys Val Met Pro Thr
        1555                1560                1565            
Val Pro Thr Ser Gln Val Thr Gly Pro Pro Pro Gln Pro Pro Pro Ile
    1570                1575                1580                
Arg Arg Glu Ile Thr Phe Pro Pro Gly Ser Val Glu Ala Ser Gln Pro
1585                1590                1595                1600
Val Leu Lys Gln Arg Arg Lys Ile Thr Ser Lys Asp Ile Val Thr Pro
                1605                1610                1615    
Glu Ala Trp Arg Val Met Met Ser Leu Lys Ser Gly Leu Leu Ala Glu
            1620                1625                1630        
Ser Thr Trp Ala Leu Asp Thr Ile Asn Ile Leu Leu Tyr Asp Asp Ser
        1635                1640                1645            
Thr Val Ala Thr Phe Asn Leu Ser Gln Leu Ser Gly Phe Leu Glu Leu
    1650                1655                1660                
Leu Val Glu Tyr Phe Arg Lys Cys Leu Ile Asp Ile Phe Gly Ile Leu
1665                1670                1675                1680
Met Glu Tyr Glu Val Gly Asp Pro Ser Gln Lys Ala Leu Asp His Asn
                1685                1690                1695    
Ala Ala Arg Lys Asp Asp Ser Gln Ser Leu Ala Asp Asp Ser Gly Lys
            1700                1705                1710        
Glu Glu Glu Asp Ala Glu Cys Ile Asp Asp Asp Glu Glu Asp Glu Glu
        1715                1720                1725            
Asp Glu Glu Glu Asp Ser Glu Lys Thr Glu Ser Asp Glu Lys Ser Ser
    1730                1735                1740                
Ile Ala Leu Thr Ala Pro Asp Ala Ala Ala Asp Pro Lys Glu Lys Pro
1745                1750                1755                1760
Lys Gln Ala Ser Lys Phe Asp Lys Leu Pro Ile Lys Ile Val Lys Lys
                1765                1770                1775    
Asn Asn Leu Phe Val Val Asp Arg Ser Asp Lys Leu Gly Arg Val Gln
            1780                1785                1790        
Glu Phe Asn Ser Gly Leu Leu His Trp Gln Leu Gly Gly Gly Asp Thr
        1795                1800                1805            
Thr Glu His Ile Gln Thr His Phe Glu Ser Lys Met Glu Ile Pro Pro
    1810                1815                1820                
Arg Arg Arg Pro Pro Pro Pro Leu Ser Ser Ala Gly Arg Lys Lys Glu
1825                1830                1835                1840
Gln Glu Gly Lys Gly Asp Ser Glu Glu Gln Gln Glu Lys Ser Ile Ile
                1845                1850                1855    
Ala Thr Ile Asp Asp Val Leu Ser Ala Arg Pro Gly Ala Leu Pro Glu
            1860                1865                1870        
Asp Ala Asn Pro Gly Pro Gln Thr Glu Ser Ser Lys Phe Pro Phe Gly
        1875                1880                1885            
Ile Gln Gln Ala Lys Ser His Arg Asn Ile Lys Leu Leu Glu Asp Glu
    1890                1895                1900                
Pro Arg Ser Arg Asp Glu Thr Pro Leu Cys Thr Ile Ala His Trp Gln
1905                1910                1915                1920
Asp Ser Leu Ala Lys Arg Cys Ile Cys Val Ser Asn Ile Val Arg Ser
                1925                1930                1935    
Leu Ser Phe Val Pro Gly Asn Asp Ala Glu Met Ser Lys His Pro Gly
            1940                1945                1950        
Leu Val Leu Ile Leu Gly Lys Leu Ile Leu Leu His His Glu His Pro
        1955                1960                1965            
Glu Arg Lys Arg Ala Pro Gln Thr Tyr Glu Lys Glu Glu Asp Glu Asp
    1970                1975                1980                
Lys Gly Val Ala Cys Ser Lys Asp Glu Trp Trp Trp Asp Cys Leu Glu
1985                1990                1995                2000
Val Leu Arg Asp Asn Thr Leu Val Thr Leu Ala Asn Ile Ser Gly Gln
                2005                2010                2015    
Leu Asp Leu Ser Ala Tyr Thr Glu Ser Ile Cys Leu Pro Ile Leu Asp
            2020                2025                2030        
Gly Leu Leu His Trp Met Val Cys Pro Ser Ala Glu Ala Gln Asp Pro
        2035                2040                2045            
Phe Pro Thr Val Gly Pro Asn Ser Val Leu Ser Pro Gln Arg Leu Val
    2050                2055                2060                
Leu Glu Thr Leu Cys Lys Leu Ser Ile Gln Asp Asn Asn Val Asp Leu
2065                2070                2075                2080
Ile Leu Ala Thr Pro Pro Phe Ser Arg Gln Glu Lys Phe Tyr Ala Thr
                2085                2090                2095    
Leu Val Arg Tyr Val Gly Asp Arg Lys Asn Pro Val Cys Arg Glu Met
            2100                2105                2110        
Ser Met Ala Leu Leu Ser Asn Leu Ala Gln Gly Asp Ala Leu Ala Ala
        2115                2120                2125            
Arg Ala Ile Ala Val Gln Lys Gly Ser Ile Gly Asn Leu Ile Ser Phe
    2130                2135                2140                
Leu Glu Asp Gly Val Thr Met Ala Gln Tyr Gln Gln Ser Gln His Asn
2145                2150                2155                2160
Leu Met His Met Gln Pro Pro Pro Leu Glu Pro Pro Ser Val Asp Met
                2165                2170                2175    
Met Cys Arg Ala Ala Lys Ala Leu Leu Ala Met Ala Arg Val Asp Glu
            2180                2185                2190        
Asn Arg Ser Glu Phe Leu Leu His Glu Gly Arg Leu Leu Asp Ile Ser
        2195                2200                2205            
Ile Ser Ala Val Leu Asn Ser Leu Val Ala Ser Val Ile Cys Asp Val
    2210                2215                2220                
Leu Phe Gln Ile Gly Gln Leu
2225                2230    


<210> 6181
<211> 471
<212> PRT
<213> Homo sapiens

<400> 6181
Met Ala Glu Lys Ile Leu Glu Lys Leu Asp Val Leu Asp Lys Gln Ala
 1               5                  10                  15      
Glu Ile Ile Leu Ala Arg Arg Thr Lys Ile Asn Arg Leu Gln Ser Glu
            20                  25                  30          
Gly Arg Lys Thr Thr Met Ala Ile Pro Leu Thr Phe Asp Phe Gln Leu
        35                  40                  45              
Glu Phe Glu Glu Ala Leu Ala Thr Ser Ala Ser Lys Ala Ile Ser Lys
    50                  55                  60                  
Ile Lys Glu Asp Lys Ser Cys Ser Ile Thr Lys Ser Lys Met His Val
65                  70                  75                  80  
Ser Phe Lys Cys Glu Pro Glu Pro Arg Lys Ser Asn Phe Glu Lys Ser
                85                  90                  95      
Asn Leu Arg Pro Phe Phe Ile Gln Thr Asn Val Lys Asn Lys Glu Ser
            100                 105                 110         
Glu Ser Thr Glu Pro Val Glu Glu His Leu Lys Ser Arg Ser Ile Arg
        115                 120                 125             
Pro Tyr Leu Tyr Leu Lys Asp Thr Thr Glu Met Glu Asn Ala Gly Pro
    130                 135                 140                 
Leu Asn Val Leu Tyr Ser Gln His Arg Gln Ala Cys Arg Arg Ser Leu
145                 150                 155                 160 
Gly Ser Thr Asp Phe Ser Pro Met Phe Asn Ile Gln Ser Asn Ala His
                165                 170                 175     
Lys Lys Glu Lys Asp Ser Thr Leu Phe Thr Ala Gln Ile Glu Lys Lys
            180                 185                 190         
Pro Arg Lys Pro Leu Asp Ser Val Gly Leu Leu Glu Gly Asp Arg Asn
        195                 200                 205             
Lys Arg Lys Lys Ser Pro Gln Met Asn Asp Phe Asn Ile Lys Glu Asn
    210                 215                 220                 
Lys Ser Val Arg Asn Tyr Gln Leu Ser Lys Tyr Arg Ser Val Arg Lys
225                 230                 235                 240 
Lys Ser Leu Leu Pro Leu Cys Phe Glu Asp Glu Leu Lys Asn Pro His
                245                 250                 255     
Ala Lys Ile Val Asn Val Ser Pro Thr Lys Thr Val Thr Ser His Met
            260                 265                 270         
Glu Gln Lys Asp Thr Asn Pro Ile Ile Phe His Asp Thr Glu Tyr Val
        275                 280                 285             
Arg Met Leu Leu Leu Thr Lys Asn Arg Phe Ser Ser His Pro Leu Glu
    290                 295                 300                 
Asn Glu Asn Ile Tyr Pro His Lys Arg Thr Asn Phe Ile Leu Glu Arg
305                 310                 315                 320 
Asn Cys Glu Ile Leu Lys Ser Ile Ile Gly Asn Gln Ser Ile Ser Leu
                325                 330                 335     
Phe Lys Pro Gln Lys Thr Met Pro Thr Val Gln Arg Lys Asp Ile Gln
            340                 345                 350         
Ile Pro Met Ser Phe Lys Ala Gly His Thr Thr Val Asp Asp Lys Leu
        355                 360                 365             
Lys Lys Lys Thr Asn Lys Gln Thr Leu Glu Asn Arg Ser Trp Asn Thr
    370                 375                 380                 
Leu Tyr Asn Phe Ser Gln Asn Phe Ser Ser Leu Thr Lys Gln Phe Val
385                 390                 395                 400 
Gly Tyr Leu Asp Lys Ala Val Ile His Glu Met Ser Ala Gln Thr Gly
                405                 410                 415     
Lys Phe Glu Arg Met Phe Ser Ala Gly Lys Pro Thr Ser Ile Pro Thr
            420                 425                 430         
Ser Ser Ala Leu Pro Val Lys Cys Tyr Ser Lys Pro Phe Lys Tyr Ile
        435                 440                 445             
Tyr Glu Leu Asn Asn Val Thr Pro Leu Asp Asn Leu Leu Asn Leu Ser
    450                 455                 460                 
Asn Glu Ile Leu Asn Ala Ser
465                 470     


<210> 6182
<211> 3802
<212> PRT
<213> Homo sapiens

<400> 6182
Met Ser Thr Asp Ser Asn Ser Leu Ala Arg Glu Phe Leu Thr Asp Val
 1               5                  10                  15      
Asn Arg Leu Cys Asn Ala Val Val Gln Arg Val Glu Ala Arg Glu Glu
            20                  25                  30          
Glu Glu Glu Glu Thr His Met Ala Thr Leu Gly Gln Tyr Leu Val His
        35                  40                  45              
Gly Arg Gly Phe Leu Leu Leu Thr Lys Leu Asn Ser Ile Ile Asp Gln
    50                  55                  60                  
Ala Leu Thr Cys Arg Glu Glu Leu Leu Thr Leu Leu Leu Ser Leu Leu
65                  70                  75                  80  
Pro Leu Val Trp Lys Ile Pro Val Gln Glu Glu Lys Ala Thr Asp Phe
                85                  90                  95      
Asn Leu Pro Leu Ser Ala Asp Ile Ile Leu Thr Lys Glu Lys Asn Ser
            100                 105                 110         
Ser Ser Gln Arg Ser Thr Gln Glu Lys Leu His Leu Glu Gly Ser Ala
        115                 120                 125             
Leu Ser Ser Gln Val Ser Ala Lys Val Asn Val Phe Arg Lys Ser Arg
    130                 135                 140                 
Arg Gln Arg Lys Ile Thr His Arg Tyr Ser Val Arg Asp Ala Arg Lys
145                 150                 155                 160 
Thr Gln Leu Ser Thr Ser Asp Ser Glu Ala Asn Ser Asp Glu Lys Gly
                165                 170                 175     
Ile Ala Met Asn Lys His Arg Arg Pro His Leu Leu His His Phe Leu
            180                 185                 190         
Thr Ser Phe Pro Lys Gln Asp His Pro Lys Ala Lys Leu Asp Arg Leu
        195                 200                 205             
Ala Thr Lys Glu Gln Thr Pro Pro Asp Ala Met Ala Leu Glu Asn Ser
    210                 215                 220                 
Arg Glu Ile Ile Pro Arg Gln Gly Ser Asn Thr Asp Ile Leu Ser Glu
225                 230                 235                 240 
Pro Ala Ala Leu Ser Val Ile Ser Asn Met Asn Asn Ser Pro Phe Asp
                245                 250                 255     
Leu Cys His Val Leu Leu Ser Leu Leu Glu Lys Val Cys Lys Phe Asp
            260                 265                 270         
Val Thr Leu Asn His Asn Ser Pro Leu Ala Ala Ser Val Val Pro Thr
        275                 280                 285             
Leu Thr Glu Phe Leu Ala Gly Phe Gly Asp Cys Cys Ser Leu Ser Asp
    290                 295                 300                 
Asn Leu Glu Ser Arg Val Val Ser Ala Gly Trp Thr Glu Glu Pro Val
305                 310                 315                 320 
Ala Leu Ile Gln Arg Met Leu Phe Arg Thr Val Leu His Leu Leu Ser
                325                 330                 335     
Val Asp Val Ser Thr Ala Glu Met Met Pro Glu Asn Leu Arg Lys Asn
            340                 345                 350         
Leu Thr Glu Leu Leu Arg Ala Ala Leu Lys Ile Arg Ile Cys Leu Glu
        355                 360                 365             
Lys Gln Pro Asp Pro Phe Ala Pro Arg Gln Lys Lys Thr Leu Gln Glu
    370                 375                 380                 
Val Gln Glu Asp Phe Val Phe Ser Lys Tyr Arg His Arg Ala Leu Leu
385                 390                 395                 400 
Leu Pro Glu Leu Leu Glu Gly Val Leu Gln Ile Leu Ile Cys Cys Leu
                405                 410                 415     
Gln Ser Ala Ala Ser Asn Pro Phe Tyr Phe Ser Gln Ala Met Asp Leu
            420                 425                 430         
Val Gln Glu Phe Ile Gln His His Gly Phe Asn Leu Phe Glu Thr Ala
        435                 440                 445             
Val Leu Gln Met Glu Trp Leu Val Leu Arg Asp Gly Val Pro Pro Glu
    450                 455                 460                 
Ala Ser Glu His Leu Lys Ala Leu Ile Asn Ser Val Met Lys Ile Met
465                 470                 475                 480 
Ser Thr Val Lys Lys Val Lys Ser Glu Gln Leu His His Ser Met Cys
                485                 490                 495     
Thr Arg Lys Arg His Arg Arg Cys Glu Tyr Ser His Phe Met His His
            500                 505                 510         
His Arg Asp Leu Ser Gly Leu Leu Val Ser Ala Phe Lys Asn Gln Val
        515                 520                 525             
Ser Lys Asn Pro Phe Glu Glu Thr Ala Asp Gly Asp Val Tyr Tyr Pro
    530                 535                 540                 
Glu Arg Cys Cys Cys Ile Ala Val Cys Ala His Gln Cys Leu Arg Leu
545                 550                 555                 560 
Leu Gln Gln Ala Ser Leu Ser Ser Thr Cys Val Gln Ile Leu Ser Gly
                565                 570                 575     
Val His Asn Ile Gly Ile Cys Cys Cys Met Asp Pro Lys Ser Val Ile
            580                 585                 590         
Ile Pro Leu Leu His Ala Phe Lys Leu Pro Ala Leu Lys Asn Phe Gln
        595                 600                 605             
Gln His Ile Leu Asn Ile Leu Asn Lys Leu Ile Leu Asp Gln Leu Gly
    610                 615                 620                 
Gly Ala Glu Ile Ser Pro Lys Ile Lys Lys Ala Ala Cys Asn Ile Cys
625                 630                 635                 640 
Thr Val Asp Ser Asp Gln Leu Ala Gln Leu Glu Glu Thr Leu Gln Gly
                645                 650                 655     
Asn Leu Cys Asp Ala Glu Leu Ser Ser Ser Leu Ser Ser Pro Ser Tyr
            660                 665                 670         
Arg Phe Gln Gly Ile Leu Pro Ser Ser Gly Ser Glu Asp Leu Leu Trp
        675                 680                 685             
Lys Trp Asp Ala Leu Lys Ala Tyr Gln Asn Phe Val Phe Glu Glu Asp
    690                 695                 700                 
Arg Leu His Ser Ile Gln Ile Ala Asn His Ile Cys Asn Leu Ile Gln
705                 710                 715                 720 
Lys Gly Asn Ile Val Val Gln Trp Lys Leu Tyr Asn Tyr Ile Phe Asn
                725                 730                 735     
Pro Val Leu Gln Arg Gly Val Glu Leu Ala His His Cys Gln His Leu
            740                 745                 750         
Ser Val Thr Ser Ala Gln Ser His Val Cys Ser His His Asn Gln Cys
        755                 760                 765             
Leu Pro Gln Asp Val Leu Gln Ile Tyr Val Lys Thr Leu Pro Ile Leu
    770                 775                 780                 
Leu Lys Ser Arg Val Ile Arg Asp Leu Phe Leu Ser Cys Asn Gly Val
785                 790                 795                 800 
Ser Gln Ile Ile Glu Leu Asn Cys Leu Asn Gly Ile Arg Ser His Ser
                805                 810                 815     
Leu Lys Ala Phe Glu Thr Leu Ile Ile Ser Leu Gly Glu Gln Gln Lys
            820                 825                 830         
Asp Ala Ser Val Pro Asp Ile Asp Gly Ile Asp Ile Glu Gln Lys Glu
        835                 840                 845             
Leu Ser Ser Val His Val Gly Thr Ser Phe His His Gln Gln Ala Tyr
    850                 855                 860                 
Ser Asp Ser Pro Gln Ser Leu Ser Lys Phe Tyr Ala Gly Leu Lys Glu
865                 870                 875                 880 
Ala Tyr Pro Lys Arg Arg Lys Thr Val Asn Gln Asp Val His Ile Asn
                885                 890                 895     
Thr Ile Asn Leu Phe Leu Cys Val Ala Phe Leu Cys Val Ser Lys Glu
            900                 905                 910         
Ala Glu Ser Asp Arg Glu Ser Ala Asn Asp Ser Glu Asp Thr Ser Gly
        915                 920                 925             
Tyr Asp Ser Thr Ala Ser Glu Pro Leu Ser His Met Leu Pro Cys Ile
    930                 935                 940                 
Ser Leu Glu Ser Leu Val Leu Pro Ser Pro Glu His Met His Gln Ala
945                 950                 955                 960 
Ala Asp Ile Trp Ser Met Cys Arg Trp Ile Tyr Met Leu Ser Ser Val
                965                 970                 975     
Phe Gln Lys Gln Phe Tyr Arg Leu Gly Gly Phe Arg Val Cys His Lys
            980                 985                 990         
Leu Ile Phe Met Ile Ile Gln Lys Leu Phe Arg Ser His Lys Glu Glu
        995                 1000                1005            
Gln Gly Lys Lys Glu Gly Asp Thr Ser Val Asn Glu Asn Gln Asp Leu
    1010                1015                1020                
Asn Arg Ile Ser Gln Pro Lys Arg Thr Met Lys Glu Asp Leu Leu Ser
1025                1030                1035                1040
Leu Ala Ile Lys Ser Asp Pro Ile Pro Ser Glu Leu Gly Ser Leu Lys
                1045                1050                1055    
Lys Ser Ala Asp Ser Leu Gly Lys Leu Glu Leu Gln His Ile Ser Ser
            1060                1065                1070        
Ile Asn Val Glu Glu Val Ser Ala Thr Glu Ala Ala Pro Glu Glu Ala
        1075                1080                1085            
Lys Leu Phe Thr Ser Gln Glu Ser Glu Thr Ser Leu Gln Ser Ile Arg
    1090                1095                1100                
Leu Leu Glu Ala Leu Leu Ala Ile Cys Leu His Gly Ala Arg Thr Ser
1105                1110                1115                1120
Gln Gln Lys Met Glu Leu Glu Leu Pro Asn Gln Asn Leu Ser Val Glu
                1125                1130                1135    
Ser Ile Leu Phe Glu Met Arg Asp His Leu Ser Gln Ser Lys Val Ile
            1140                1145                1150        
Glu Thr Gln Leu Ala Lys Pro Leu Phe Asp Ala Leu Leu Arg Val Ala
        1155                1160                1165            
Leu Gly Asn Tyr Ser Ala Asp Phe Glu His Asn Asp Ala Met Thr Glu
    1170                1175                1180                
Lys Ser His Gln Ser Ala Glu Glu Leu Ser Ser Gln Pro Gly Asp Phe
1185                1190                1195                1200
Ser Glu Glu Ala Glu Asp Ser Gln Cys Cys Ser Phe Lys Leu Leu Val
                1205                1210                1215    
Glu Glu Glu Gly Tyr Glu Ala Asp Ser Glu Ser Asn Pro Glu Asp Gly
            1220                1225                1230        
Glu Thr Gln Asp Asp Gly Val Asp Leu Lys Ser Glu Thr Glu Gly Phe
        1235                1240                1245            
Ser Ala Ser Ser Ser Pro Asn Asp Leu Leu Glu Asn Leu Thr Gln Gly
    1250                1255                1260                
Glu Ile Ile Tyr Pro Glu Ile Cys Met Leu Glu Leu Asn Leu Leu Ser
1265                1270                1275                1280
Ala Ser Lys Ala Lys Leu Asp Val Leu Ala His Val Phe Glu Ser Phe
                1285                1290                1295    
Leu Lys Ile Ile Arg Gln Lys Glu Lys Asn Val Phe Leu Leu Met Gln
            1300                1305                1310        
Gln Gly Thr Val Lys Asn Leu Leu Gly Gly Phe Leu Ser Ile Leu Thr
        1315                1320                1325            
Gln Asp Asp Ser Asp Phe Gln Ala Cys Gln Arg Val Leu Val Asp Leu
    1330                1335                1340                
Leu Val Ser Leu Met Ser Ser Arg Thr Cys Ser Glu Glu Leu Thr Leu
1345                1350                1355                1360
Leu Leu Arg Ile Phe Leu Glu Lys Ser Pro Cys Thr Lys Ile Leu Leu
                1365                1370                1375    
Leu Gly Ile Leu Lys Ile Ile Glu Ser Asp Thr Thr Met Ser Pro Ser
            1380                1385                1390        
Gln Tyr Leu Thr Phe Pro Leu Leu His Ala Pro Asn Leu Ser Asn Gly
        1395                1400                1405            
Val Ser Ser Gln Lys Tyr Pro Gly Ile Leu Asn Ser Lys Ala Met Gly
    1410                1415                1420                
Leu Leu Arg Arg Ala Arg Val Ser Arg Ser Lys Lys Glu Ala Asp Arg
1425                1430                1435                1440
Glu Ser Phe Pro His Arg Leu Leu Ser Ser Trp His Ile Ala Pro Val
                1445                1450                1455    
His Leu Pro Leu Leu Gly Gln Asn Cys Trp Pro His Leu Ser Glu Gly
            1460                1465                1470        
Phe Ser Val Ser Leu Trp Phe Asn Val Glu Cys Ile His Glu Ala Glu
        1475                1480                1485            
Ser Thr Thr Glu Lys Gly Lys Lys Ile Lys Lys Arg Asn Lys Ser Leu
    1490                1495                1500                
Ile Leu Pro Asp Ser Ser Phe Asp Gly Thr Glu Ser Asp Arg Pro Glu
1505                1510                1515                1520
Gly Ala Glu Tyr Ile Asn Pro Gly Glu Arg Leu Ile Glu Glu Gly Cys
                1525                1530                1535    
Ile His Ile Ile Ser Leu Gly Ser Lys Ala Leu Met Ile Gln Val Trp
            1540                1545                1550        
Ala Asp Pro His Asn Ala Thr Leu Ile Phe Arg Val Cys Met Asp Ser
        1555                1560                1565            
Asn Asp Asp Met Lys Ala Val Leu Leu Ala Gln Val Glu Ser Gln Glu
    1570                1575                1580                
Asn Ile Phe Leu Pro Ser Lys Trp Gln His Leu Val Leu Thr Tyr Leu
1585                1590                1595                1600
Gln Gln Pro Gln Gly Lys Arg Arg Ile His Gly Lys Ile Ser Ile Trp
                1605                1610                1615    
Val Ser Gly Gln Arg Lys Pro Asp Val Thr Leu Asp Phe Met Leu Pro
            1620                1625                1630        
Arg Lys Thr Ser Leu Ser Ser Asp Ser Asn Lys Thr Phe Cys Met Ile
        1635                1640                1645            
Gly His Cys Leu Ser Ser Gln Glu Glu Phe Leu Gln Leu Ala Gly Lys
    1650                1655                1660                
Trp Asp Leu Gly Asn Leu Leu Leu Phe Asn Gly Ala Lys Val Gly Ser
1665                1670                1675                1680
Gln Glu Ala Phe Tyr Leu Tyr Ala Cys Gly Pro Asn His Thr Ser Val
                1685                1690                1695    
Met Pro Cys Lys Tyr Gly Lys Pro Val Asn Asp Tyr Ser Lys Tyr Ile
            1700                1705                1710        
Asn Lys Glu Ile Leu Arg Cys Glu Gln Ile Arg Glu Leu Phe Met Thr
        1715                1720                1725            
Lys Lys Asp Val Asp Ile Gly Leu Leu Ile Glu Ser Leu Ser Val Val
    1730                1735                1740                
Tyr Thr Thr Tyr Cys Pro Ala Gln Tyr Thr Ile Tyr Glu Pro Val Ile
1745                1750                1755                1760
Arg Leu Lys Gly Gln Met Lys Thr Gln Leu Ser Gln Arg Pro Phe Ser
                1765                1770                1775    
Ser Lys Glu Val Gln Ser Ile Leu Leu Glu Pro His His Leu Lys Asn
            1780                1785                1790        
Leu Gln Pro Thr Glu Tyr Lys Thr Ile Gln Gly Ile Leu His Glu Ile
        1795                1800                1805            
Gly Gly Thr Gly Ile Phe Val Phe Leu Phe Ala Arg Val Val Glu Leu
    1810                1815                1820                
Ser Ser Cys Glu Glu Thr Gln Ala Leu Ala Leu Arg Val Ile Leu Ser
1825                1830                1835                1840
Leu Ile Lys Tyr Asn Gln Gln Arg Val His Glu Leu Glu Asn Cys Asn
                1845                1850                1855    
Gly Leu Ser Met Ile His Gln Val Leu Ile Lys Gln Lys Cys Ile Val
            1860                1865                1870        
Gly Phe Tyr Ile Leu Lys Thr Leu Leu Glu Gly Cys Cys Gly Glu Asp
        1875                1880                1885            
Ile Ile Tyr Met Asn Glu Asn Gly Glu Phe Lys Leu Asp Val Asp Ser
    1890                1895                1900                
Asn Ala Ile Ile Gln Asp Val Lys Leu Leu Glu Glu Leu Leu Leu Asp
1905                1910                1915                1920
Trp Lys Ile Trp Ser Lys Ala Glu Ala Cys Val Trp Glu Thr Leu Leu
                1925                1930                1935    
Ala Ala Leu Glu Val Leu Ile Arg Ala Asp His His Gln Gln Met Phe
            1940                1945                1950        
Asn Ile Lys Gln Leu Leu Lys Ala Gln Val Val His His Phe Leu Leu
        1955                1960                1965            
Thr Cys Gln Val Leu Gln Glu Tyr Lys Glu Gly Gln Leu Thr Pro Met
    1970                1975                1980                
Pro Arg Glu Val Cys Arg Ser Phe Val Lys Ile Ile Ala Glu Val Leu
1985                1990                1995                2000
Gly Ser Pro Pro Asp Leu Glu Leu Leu Thr Ile Ile Phe Asn Phe Leu
                2005                2010                2015    
Leu Ala Val His Pro Pro Thr Asn Thr Tyr Val Cys His Asn Pro Thr
            2020                2025                2030        
Asn Phe Tyr Phe Ser Leu His Ile Asp Gly Lys Ile Phe Gln Glu Lys
        2035                2040                2045            
Val Arg Ser Ile Met Tyr Leu Arg His Ser Ser Ser Gly Gly Arg Ser
    2050                2055                2060                
Leu Met Ser Pro Gly Phe Met Val Ile Ser Pro Ser Gly Phe Thr Ala
2065                2070                2075                2080
Ser Pro Tyr Glu Gly Glu Asn Ser Ser Asn Ile Ile Pro Gln Gln Met
                2085                2090                2095    
Ala Ala His Met Leu Arg Ser Arg Ser Leu Pro Ala Phe Pro Thr Ser
            2100                2105                2110        
Ser Leu Leu Thr Gln Ser Gln Lys Leu Thr Gly Ser Leu Gly Cys Ser
        2115                2120                2125            
Ile Asp Arg Leu Gln Asn Ile Ala Asp Thr Tyr Val Ala Thr Gln Ser
    2130                2135                2140                
Lys Lys Gln Asn Ser Leu Gly Ser Ser Asp Thr Leu Lys Lys Gly Lys
2145                2150                2155                2160
Glu Asp Ala Phe Ile Ser Ser Cys Glu Ser Ala Lys Thr Val Cys Glu
                2165                2170                2175    
Met Glu Ala Val Leu Ser Ala Gln Val Ser Val Ser Asp Val Pro Lys
            2180                2185                2190        
Gly Val Leu Gly Phe Pro Val Val Lys Ala Asp His Lys Gln Leu Gly
        2195                2200                2205            
Ala Glu Pro Arg Ser Glu Asp Asp Ser Pro Gly Asp Glu Ser Cys Pro
    2210                2215                2220                
Arg Arg Pro Asp Tyr Leu Lys Gly Leu Ala Ser Phe Gln Arg Ser His
2225                2230                2235                2240
Ser Thr Ile Ala Ser Leu Gly Leu Ala Phe Pro Ser Gln Asn Gly Ser
                2245                2250                2255    
Ala Ala Val Gly Arg Trp Pro Ser Leu Val Asp Arg Asn Thr Asp Asp
            2260                2265                2270        
Trp Glu Asn Phe Ala Tyr Ser Leu Gly Tyr Glu Pro Asn Tyr Asn Arg
        2275                2280                2285            
Thr Ala Ser Ala His Ser Val Thr Glu Asp Cys Leu Val Pro Ile Cys
    2290                2295                2300                
Cys Gly Leu Tyr Glu Leu Leu Ser Gly Val Leu Leu Ile Leu Pro Asp
2305                2310                2315                2320
Val Leu Leu Glu Asp Val Met Asp Lys Leu Ile Gln Ala Asp Thr Leu
                2325                2330                2335    
Leu Val Leu Val Asn His Pro Ser Pro Ala Ile Gln Gln Gly Val Ile
            2340                2345                2350        
Lys Leu Leu Asp Ala Tyr Phe Ala Arg Ala Ser Lys Glu Gln Lys Asp
        2355                2360                2365            
Lys Phe Leu Lys Asn Arg Gly Phe Ser Leu Leu Ala Asn Gln Leu Tyr
    2370                2375                2380                
Leu His Arg Gly Thr Gln Glu Leu Leu Glu Cys Phe Ile Glu Met Phe
2385                2390                2395                2400
Phe Gly Arg His Ile Gly Leu Asp Glu Glu Phe Asp Leu Glu Asp Val
                2405                2410                2415    
Arg Asn Met Gly Leu Phe Gln Lys Trp Ser Val Ile Pro Ile Leu Gly
            2420                2425                2430        
Leu Ile Glu Thr Ser Leu Tyr Asp Asn Ile Leu Leu His Asn Ala Leu
        2435                2440                2445            
Leu Leu Leu Leu Gln Ile Leu Asn Ser Cys Ser Lys Val Ala Asp Met
    2450                2455                2460                
Leu Leu Asp Asn Gly Leu Leu Tyr Val Leu Cys Asn Thr Val Ala Ala
2465                2470                2475                2480
Leu Asn Gly Leu Glu Lys Asn Ile Pro Met Ser Glu Tyr Lys Leu Leu
                2485                2490                2495    
Ala Cys Asp Ile Gln Gln Leu Phe Ile Ala Val Thr Ile His Ala Cys
            2500                2505                2510        
Ser Ser Ser Gly Ser Gln Tyr Phe Arg Val Ile Glu Asp Leu Ile Val
        2515                2520                2525            
Met Leu Gly Tyr Leu Gln Asn Ser Lys Asn Lys Arg Thr Gln Asn Met
    2530                2535                2540                
Ala Val Ala Leu Gln Leu Arg Val Leu Gln Ala Ala Met Glu Phe Ile
2545                2550                2555                2560
Arg Thr Thr Ala Asn His Asp Ser Glu Asn Leu Thr Asp Ser Leu Gln
                2565                2570                2575    
Ser Pro Ser Ala Pro His His Ala Val Val Gln Lys Arg Lys Ser Ile
            2580                2585                2590        
Ala Gly Glu Pro Arg Lys Phe Pro Leu Ala Gln Thr Glu Ser Leu Leu
        2595                2600                2605            
Met Lys Met Arg Ser Val Ala Asn Asp Glu Leu His Val Met Met Gln
    2610                2615                2620                
Arg Arg Met Ser Gln Glu Asn Pro Ser Gln Ala Thr Glu Thr Glu Leu
2625                2630                2635                2640
Ala Gln Arg Leu Gln Arg Leu Thr Val Leu Ala Val Asn Arg Ile Ile
                2645                2650                2655    
Tyr Gln Glu Phe Asn Ser Asp Ile Ile Asp Ile Leu Arg Thr Pro Glu
            2660                2665                2670        
Asn Val Thr Gln Ser Lys Thr Ser Val Phe Gln Thr Glu Ile Ser Glu
        2675                2680                2685            
Glu Asn Ile His His Glu Gln Ser Ser Val Phe Asn Pro Phe Gln Lys
    2690                2695                2700                
Glu Ile Phe Thr Tyr Leu Val Glu Gly Phe Lys Val Ser Ile Gly Ser
2705                2710                2715                2720
Ser Lys Ala Ser Gly Ser Lys Gln Gln Trp Thr Lys Ile Leu Trp Ser
                2725                2730                2735    
Cys Lys Glu Thr Phe Arg Met Gln Leu Gly Arg Leu Leu Val His Ile
            2740                2745                2750        
Leu Ser Pro Ala His Ala Ala Gln Glu Arg Lys Gln Ile Phe Glu Ile
        2755                2760                2765            
Val His Glu Pro Asn His Gln Glu Ile Leu Arg Asp Cys Leu Ser Pro
    2770                2775                2780                
Ser Leu Gln His Gly Ala Lys Leu Val Leu Tyr Leu Ser Glu Leu Ile
2785                2790                2795                2800
His Asn His Gln Gly Glu Leu Thr Glu Glu Glu Leu Gly Thr Ala Glu
                2805                2810                2815    
Leu Leu Met Asn Ala Leu Lys Leu Cys Gly His Lys Cys Ile Pro Pro
            2820                2825                2830        
Ser Ala Ser Thr Lys Ala Asp Leu Ile Lys Met Ile Lys Glu Glu Gln
        2835                2840                2845            
Lys Lys Tyr Glu Thr Glu Glu Gly Val Asn Lys Ala Ala Trp Gln Lys
    2850                2855                2860                
Thr Val Asn Asn Asn Gln Gln Ser Leu Phe Gln Arg Leu Asp Ser Lys
2865                2870                2875                2880
Ser Lys Asp Ile Ser Lys Ile Ala Ala Asp Ile Thr Gln Ala Val Ser
                2885                2890                2895    
Leu Ser Gln Gly Asn Glu Arg Lys Lys Val Ile Gln His Ile Arg Gly
            2900                2905                2910        
Met Tyr Lys Val Asp Leu Ser Ala Ser Arg His Trp Gln Glu Leu Ile
        2915                2920                2925            
Gln Gln Leu Thr His Asp Arg Ala Val Trp Tyr Asp Pro Ile Tyr Tyr
    2930                2935                2940                
Pro Thr Ser Trp Gln Leu Asp Pro Thr Glu Gly Pro Asn Arg Glu Arg
2945                2950                2955                2960
Arg Arg Leu Gln Arg Cys Tyr Leu Thr Ile Pro Asn Lys Tyr Leu Leu
                2965                2970                2975    
Arg Asp Arg Gln Lys Ser Glu Asp Val Val Lys Pro Pro Leu Ser Tyr
            2980                2985                2990        
Leu Phe Glu Asp Lys Thr His Ser Ser Phe Ser Ser Thr Val Lys Asp
        2995                3000                3005            
Lys Ala Ala Ser Glu Ser Ile Arg Val Asn Arg Arg Cys Ile Ser Val
    3010                3015                3020                
Ala Pro Ser Arg Glu Thr Ala Gly Glu Leu Leu Leu Gly Lys Cys Gly
3025                3030                3035                3040
Met Tyr Phe Val Glu Asp Asn Ala Ser Asp Thr Val Glu Ser Ser Ser
                3045                3050                3055    
Leu Gln Gly Glu Leu Glu Pro Ala Ser Phe Ser Trp Thr Tyr Glu Glu
            3060                3065                3070        
Ile Lys Glu Val His Lys Arg Trp Trp Gln Leu Arg Asp Asn Ala Val
        3075                3080                3085            
Glu Ile Phe Leu Thr Asn Gly Arg Thr Leu Leu Leu Ala Phe Asp Asn
    3090                3095                3100                
Thr Lys Val Arg Asp Asp Val Tyr His Asn Ile Leu Thr Asn Asn Leu
3105                3110                3115                3120
Pro Asn Leu Leu Glu Tyr Gly Asn Ile Thr Ala Leu Thr Asn Leu Trp
                3125                3130                3135    
Tyr Thr Gly Gln Ile Thr Asn Phe Glu Tyr Leu Thr His Leu Asn Lys
            3140                3145                3150        
His Ala Gly Arg Ser Phe Asn Asp Leu Met Gln Tyr Pro Val Phe Pro
        3155                3160                3165            
Phe Ile Leu Ala Asp Tyr Val Ser Glu Thr Leu Asp Leu Asn Asp Leu
    3170                3175                3180                
Leu Ile Tyr Arg Asn Leu Ser Lys Pro Ile Ala Val Gln Tyr Lys Glu
3185                3190                3195                3200
Lys Glu Asp Arg Tyr Val Asp Thr Tyr Lys Tyr Leu Glu Glu Glu Tyr
                3205                3210                3215    
Arg Lys Gly Ala Arg Glu Asp Asp Pro Met Pro Pro Val Gln Pro Tyr
            3220                3225                3230        
His Tyr Gly Ser His Tyr Ser Asn Ser Gly Thr Val Leu His Phe Leu
        3235                3240                3245            
Val Arg Met Pro Pro Phe Thr Lys Met Phe Leu Ala Tyr Gln Asp Gln
    3250                3255                3260                
Ser Phe Asp Ile Pro Asp Arg Thr Phe His Ser Thr Asn Thr Thr Trp
3265                3270                3275                3280
Arg Leu Ser Ser Phe Glu Ser Met Thr Asp Val Lys Glu Leu Ile Pro
                3285                3290                3295    
Glu Phe Phe Tyr Leu Pro Glu Phe Leu Val Asn Arg Glu Gly Phe Asp
            3300                3305                3310        
Phe Gly Val Arg Gln Asn Gly Glu Arg Val Asn His Val Asn Leu Pro
        3315                3320                3325            
Pro Trp Ala Arg Asn Asp Pro Arg Leu Phe Ile Leu Ile His Arg Gln
    3330                3335                3340                
Ala Leu Glu Ser Asp Tyr Val Ser Gln Asn Ile Cys Gln Trp Ile Asp
3345                3350                3355                3360
Leu Val Phe Gly Tyr Lys Gln Lys Gly Lys Ala Ser Val Gln Ala Ile
                3365                3370                3375    
Asn Val Phe His Pro Ala Thr Tyr Phe Gly Met Asp Val Ser Ala Val
            3380                3385                3390        
Glu Asp Pro Val Gln Arg Arg Ala Leu Glu Thr Met Ile Lys Thr Tyr
        3395                3400                3405            
Gly Gln Thr Pro Arg Gln Leu Phe His Met Ala His Val Ser Arg Pro
    3410                3415                3420                
Gly Ala Lys Leu Asn Ile Glu Gly Glu Leu Pro Ala Ala Val Gly Leu
3425                3430                3435                3440
Leu Val Gln Phe Ala Phe Arg Glu Thr Arg Glu Gln Val Lys Glu Ile
                3445                3450                3455    
Thr Tyr Pro Ser Pro Leu Ser Trp Ile Lys Gly Leu Lys Trp Gly Glu
            3460                3465                3470        
Tyr Val Gly Ser Pro Ser Ala Pro Val Pro Val Val Cys Phe Ser Gln
        3475                3480                3485            
Pro His Gly Glu Arg Phe Gly Ser Leu Gln Ala Leu Pro Thr Arg Ala
    3490                3495                3500                
Ile Cys Gly Leu Ser Arg Asn Phe Cys Leu Leu Met Thr Tyr Ser Lys
3505                3510                3515                3520
Glu Gln Gly Val Arg Ser Met Asn Ser Thr Asp Ile Gln Trp Ser Ala
                3525                3530                3535    
Ile Leu Ser Trp Gly Tyr Ala Asp Asn Ile Leu Arg Leu Lys Ser Lys
            3540                3545                3550        
Gln Ser Glu Pro Pro Val Asn Phe Ile Gln Ser Ser Gln Gln Tyr Gln
        3555                3560                3565            
Val Thr Ser Cys Ala Trp Val Pro Asp Ser Cys Gln Leu Phe Thr Gly
    3570                3575                3580                
Ser Lys Cys Gly Val Ile Thr Ala Tyr Thr Asn Arg Phe Thr Ser Ser
3585                3590                3595                3600
Thr Pro Ser Glu Ile Glu Met Glu Thr Gln Ile His Leu Tyr Gly His
                3605                3610                3615    
Thr Glu Glu Ile Thr Ser Leu Phe Val Cys Lys Pro Tyr Ser Ile Leu
            3620                3625                3630        
Ile Ser Val Ser Arg Asp Gly Thr Cys Ile Ile Trp Asp Leu Asn Arg
        3635                3640                3645            
Leu Cys Tyr Val Gln Ser Leu Ala Gly His Lys Ser Pro Val Thr Ala
    3650                3655                3660                
Val Ser Ala Ser Glu Thr Ser Gly Asp Ile Ala Thr Val Cys Asp Ser
3665                3670                3675                3680
Ala Gly Gly Gly Ser Asp Leu Arg Leu Trp Thr Val Asn Gly Asp Leu
                3685                3690                3695    
Val Gly His Val His Cys Arg Glu Ile Ile Cys Ser Val Ala Phe Ser
            3700                3705                3710        
Asn Gln Pro Glu Gly Val Ser Ile Asn Val Ile Ala Gly Gly Leu Glu
        3715                3720                3725            
Asn Gly Ile Val Arg Leu Trp Ser Thr Trp Asp Leu Lys Pro Val Arg
    3730                3735                3740                
Glu Ile Thr Phe Pro Lys Ser Asn Lys Pro Ile Ile Ser Leu Thr Phe
3745                3750                3755                3760
Ser Cys Asp Gly His His Leu Tyr Thr Ala Asn Ser Asp Gly Thr Val
                3765                3770                3775    
Ile Ala Trp Cys Arg Lys Asp Gln Gln Arg Leu Lys Gln Pro Met Phe
            3780                3785                3790        
Tyr Ser Phe Leu Ser Ser Tyr Ala Ala Gly
        3795                3800        


<210> 6183
<211> 913
<212> PRT
<213> Homo sapiens

<400> 6183
Met Ala Ala Leu Phe Leu Arg Gly Phe Val Gln Ile Gly Asn Cys Lys
 1               5                  10                  15      
Thr Gly Ile Ser Lys Ser Lys Glu Ala Phe Ile Glu Ala Val Glu Arg
            20                  25                  30          
Lys Lys Lys Asp Arg Leu Val Leu Tyr Phe Lys Ser Gly Lys Tyr Ser
        35                  40                  45              
Thr Phe Arg Leu Ser Asp Asn Ile Gln Asn Val Val Leu Lys Ser Tyr
    50                  55                  60                  
Arg Gly Asn Gln Asn His Leu His Leu Thr Leu Gln Asn Asn Asn Gly
65                  70                  75                  80  
Leu Phe Ile Glu Gly Leu Ser Ser Thr Asp Ala Glu Gln Leu Lys Ile
                85                  90                  95      
Phe Leu Asp Arg Val His Gln Asn Glu Val Gln Pro Pro Val Arg Pro
            100                 105                 110         
Gly Lys Gly Gly Ser Val Phe Ser Ser Thr Thr Gln Lys Glu Ile Asn
        115                 120                 125             
Lys Thr Ser Phe His Lys Val Asp Glu Lys Ser Ser Ser Lys Ser Phe
    130                 135                 140                 
Glu Ile Ala Lys Gly Ser Gly Thr Gly Val Leu Gln Arg Met Pro Leu
145                 150                 155                 160 
Leu Thr Ser Lys Leu Thr Leu Thr Cys Gly Glu Leu Ser Glu Asn Gln
                165                 170                 175     
His Lys Lys Arg Lys Arg Met Leu Ser Ser Ser Ser Glu Met Asn Glu
            180                 185                 190         
Glu Phe Leu Lys Glu Asn Asn Ser Val Glu Tyr Lys Lys Ser Lys Ala
        195                 200                 205             
Asp Cys Ser Arg Cys Val Ser Tyr Asn Arg Glu Lys Gln Leu Lys Leu
    210                 215                 220                 
Lys Glu Leu Glu Glu Asn Lys Lys Leu Glu Cys Glu Ser Ser Cys Ile
225                 230                 235                 240 
Met Asn Ala Thr Gly Asn Pro Tyr Leu Asp Asp Ile Gly Leu Leu Gln
                245                 250                 255     
Ala Leu Thr Glu Lys Met Val Leu Val Phe Leu Leu Gln Gln Gly Tyr
            260                 265                 270         
Ser Asp Gly Tyr Thr Lys Trp Asp Lys Leu Lys Leu Phe Phe Glu Leu
        275                 280                 285             
Phe Pro Glu Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys
    290                 295                 300                 
Tyr Met Asn Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala
305                 310                 315                 320 
Asp Asp Leu Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn
                325                 330                 335     
Ala Leu Thr Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr
            340                 345                 350         
Asn Ile Glu Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile
        355                 360                 365             
Ser Ala Ala Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His
    370                 375                 380                 
Glu Phe Leu Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys
385                 390                 395                 400 
Leu Asn Thr Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe
                405                 410                 415     
Pro Lys Gln Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys
            420                 425                 430         
Pro Val Ile Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys
        435                 440                 445             
Lys Ala Cys Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu
    450                 455                 460                 
Ser Ile Asn Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln
465                 470                 475                 480 
Ser Thr Phe Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys
                485                 490                 495     
Ala Lys Cys Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg
            500                 505                 510         
Leu Pro Arg Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu
        515                 520                 525             
Phe Cys Ala Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr
    530                 535                 540                 
Leu Lys Val Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro
545                 550                 555                 560 
Leu Ser Glu Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile
                565                 570                 575     
Arg Lys Met Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys
            580                 585                 590         
Glu Ser Lys Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser
        595                 600                 605             
Glu Gln Lys Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln
    610                 615                 620                 
Gln Gln Lys Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser
625                 630                 635                 640 
Val Tyr Ser Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His
                645                 650                 655     
Leu Met Thr Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala
            660                 665                 670         
Gly Gly Lys Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp
        675                 680                 685             
Phe Gln Thr Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr
    690                 695                 700                 
Ser Lys Phe Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu
705                 710                 715                 720 
Tyr Glu Asp Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser
                725                 730                 735     
Glu Gln Thr Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro
            740                 745                 750         
Gln Gln Ala Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His
        755                 760                 765             
Thr Lys Asn Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn
    770                 775                 780                 
Arg Asn Ser Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys
785                 790                 795                 800 
Asp Ile Leu Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn
                805                 810                 815     
Asp Asp Lys Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His
            820                 825                 830         
Leu Gly Lys Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp
        835                 840                 845             
Phe Glu Lys Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly
    850                 855                 860                 
Ile Gln Glu Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile
865                 870                 875                 880 
Phe Phe Tyr Met His Asn Glu Ile Phe Glu Glu Met Leu Lys Arg Glu
                885                 890                 895     
Glu Asn Ala Gln Leu Asn Ser Lys Glu Val Glu Glu Thr Leu Gln Lys
            900                 905                 910         
Glu
    


<210> 6184
<211> 126
<212> PRT
<213> Homo sapiens

<400> 6184
Met Ser Ile Gly Val Pro Ile Lys Val Leu His Glu Ala Glu Gly His
 1               5                  10                  15      
Ile Val Thr Cys Glu Thr Asn Thr Gly Glu Val Tyr Arg Gly Lys Leu
            20                  25                  30          
Ile Glu Ala Glu Asp Asn Met Asn Cys Gln Met Ser Asn Ile Thr Val
        35                  40                  45              
Thr Tyr Arg Asp Gly Arg Val Ala Gln Leu Glu Gln Val Tyr Ile Arg
    50                  55                  60                  
Gly Ser Lys Ile Arg Phe Leu Ile Leu Pro Asp Met Leu Lys Asn Ala
65                  70                  75                  80  
Pro Met Leu Lys Ser Met Lys Asn Lys Asn Gln Gly Ser Gly Ala Gly
                85                  90                  95      
Arg Gly Lys Ala Ala Ile Leu Lys Ala Gln Val Ala Ala Arg Gly Arg
            100                 105                 110         
Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln Lys Arg Arg
        115                 120                 125     


<210> 6185
<211> 163
<212> PRT
<213> Homo sapiens

<400> 6185
Met Ser Phe Asn Cys Ser Thr Arg Asn Cys Ser Ser Arg Pro Ile Gly
 1               5                  10                  15      
Gly Arg Cys Ile Val Pro Val Ala Gln Val Thr Thr Thr Ser Thr Thr
            20                  25                  30          
Asp Ala Asp Cys Leu Gly Gly Ile Cys Leu Pro Ser Ser Phe Gln Thr
        35                  40                  45              
Gly Ser Trp Leu Leu Asp His Cys Gln Glu Thr Cys Cys Glu Pro Thr
    50                  55                  60                  
Ala Cys Gln Pro Thr Cys Tyr Arg Arg Thr Ser Cys Val Ser Asn Pro
65                  70                  75                  80  
Cys Gln Val Thr Cys Ser Arg Gln Thr Thr Cys Ile Ser Asn Pro Cys
                85                  90                  95      
Ser Thr Thr Tyr Ser Arg Pro Leu Thr Phe Val Ser Ser Gly Cys Gln
            100                 105                 110         
Pro Leu Gly Gly Ile Ser Ser Val Cys Gln Pro Val Gly Gly Ile Ser
        115                 120                 125             
Thr Val Cys Gln Pro Val Gly Gly Val Ser Thr Val Cys Gln Pro Ala
    130                 135                 140                 
Cys Gly Val Ser Arg Thr Tyr Gln Gln Ser Cys Val Ser Ser Cys Arg
145                 150                 155                 160 
Arg Thr Cys
            


<210> 6186
<211> 357
<212> PRT
<213> Homo sapiens

<400> 6186
Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala
 1               5                  10                  15      
Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly
            20                  25                  30          
Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu
        35                  40                  45              
Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser
    50                  55                  60                  
Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn
65                  70                  75                  80  
Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu
                85                  90                  95      
Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu
            100                 105                 110         
Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val
        115                 120                 125             
Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp
    130                 135                 140                 
Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys
145                 150                 155                 160 
Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp
                165                 170                 175     
Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val
            180                 185                 190         
Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly
        195                 200                 205             
Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu
    210                 215                 220                 
Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe
225                 230                 235                 240 
Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile
                245                 250                 255     
Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln
            260                 265                 270         
Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn
        275                 280                 285             
Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser
    290                 295                 300                 
Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg
305                 310                 315                 320 
Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser
                325                 330                 335     
Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys
            340                 345                 350         
Pro Glu Ser Leu Ser
        355         


<210> 6187
<211> 385
<212> PRT
<213> Homo sapiens

<400> 6187
Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala
 1               5                  10                  15      
Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly
            20                  25                  30          
Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu
        35                  40                  45              
Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser
    50                  55                  60                  
Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn
65                  70                  75                  80  
Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu
                85                  90                  95      
Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu
            100                 105                 110         
Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val
        115                 120                 125             
Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp
    130                 135                 140                 
Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys
145                 150                 155                 160 
Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp
                165                 170                 175     
Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val
            180                 185                 190         
Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly
        195                 200                 205             
Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu
    210                 215                 220                 
Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe
225                 230                 235                 240 
Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile
                245                 250                 255     
Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln
            260                 265                 270         
Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn
        275                 280                 285             
Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser
    290                 295                 300                 
Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg
305                 310                 315                 320 
Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser
                325                 330                 335     
Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Leu Ala Pro Ser Thr
            340                 345                 350         
Leu Cys Ser Phe Ile Ser Ser Ser Ser Gly Val Ser Gly Val Gly Ala
        355                 360                 365             
Glu Arg Arg Pro Arg Pro Thr Thr Val Thr Ala Val His Ser Gly Ser
    370                 375                 380                 
Lys
385 


<210> 6188
<211> 265
<212> PRT
<213> Homo sapiens

<400> 6188
Met Ala Ala Ile Gly Arg Gly Arg Ser Leu Lys Asn Leu Arg Val Arg
 1               5                  10                  15      
Gly Arg Asn Asp Ser Gly Glu Glu Asn Val Pro Leu Asp Leu Thr Arg
            20                  25                  30          
Glu Pro Ser Asp Asn Leu Arg Glu Ile Leu Gln Asn Val Ala Arg Leu
        35                  40                  45              
Gln Gly Val Ser Asn Met Arg Lys Leu Gly His Leu Asn Asn Phe Thr
    50                  55                  60                  
Lys Leu Leu Cys Asp Ile Gly His Ser Glu Glu Lys Leu Gly Phe His
65                  70                  75                  80  
Tyr Glu Asp Ile Ile Ile Cys Leu Arg Leu Ala Leu Leu Asn Glu Ala
                85                  90                  95      
Lys Glu Val Arg Ala Ala Gly Leu Arg Ala Leu Arg Tyr Leu Ile Gln
            100                 105                 110         
Asp Ser Ser Ile Leu Gln Lys Val Leu Lys Leu Lys Val Asp Tyr Leu
        115                 120                 125             
Ile Ala Arg Cys Ile Asp Ile Gln Gln Ser Asn Glu Val Glu Arg Thr
    130                 135                 140                 
Gln Ala Leu Arg Leu Val Arg Lys Met Ile Thr Val Asn Ala Ser Leu
145                 150                 155                 160 
Phe Pro Ser Ser Val Thr Asn Ser Leu Ile Ala Val Gly Asn Asp Gly
                165                 170                 175     
Leu Gln Glu Arg Asp Arg Met Val Arg Ala Cys Ile Ala Ile Ile Cys
            180                 185                 190         
Glu Leu Ala Leu Gln Asn Pro Glu Val Val Ala Leu Arg Gly Gly Leu
        195                 200                 205             
Asn Thr Ile Leu Lys Asn Val Ile Asp Cys Gln Leu Ser Arg Ile Asn
    210                 215                 220                 
Glu Ala Leu Ile Thr Thr Ile Leu His Leu Leu Asn His Pro Lys Thr
225                 230                 235                 240 
Arg Gln Tyr Val Arg Ala Asp Val Glu Leu Glu Val Gly Thr Leu Ile
                245                 250                 255     
Phe Phe Ser Ser Phe Lys Ile Leu Leu
            260                 265 


<210> 6189
<211> 687
<212> PRT
<213> Homo sapiens

<400> 6189
Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr
 1               5                  10                  15      
Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val
            20                  25                  30          
Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg
        35                  40                  45              
Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly
    50                  55                  60                  
Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg
65                  70                  75                  80  
Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln
                85                  90                  95      
Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile
            100                 105                 110         
Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser
        115                 120                 125             
Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro
    130                 135                 140                 
Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val
145                 150                 155                 160 
Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys
                165                 170                 175     
Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile
            180                 185                 190         
Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly
        195                 200                 205             
Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val
    210                 215                 220                 
Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg
225                 230                 235                 240 
Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly
                245                 250                 255     
Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val
            260                 265                 270         
Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu
        275                 280                 285             
Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala
    290                 295                 300                 
His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe
305                 310                 315                 320 
Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys
                325                 330                 335     
Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu
            340                 345                 350         
Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr
        355                 360                 365             
Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu
    370                 375                 380                 
Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp
385                 390                 395                 400 
Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile
                405                 410                 415     
Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly
            420                 425                 430         
Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly
        435                 440                 445             
Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys
    450                 455                 460                 
Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly
465                 470                 475                 480 
Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr
                485                 490                 495     
Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg
            500                 505                 510         
Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr
        515                 520                 525             
Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu
    530                 535                 540                 
Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu
545                 550                 555                 560 
Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu
                565                 570                 575     
Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg
            580                 585                 590         
Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser
        595                 600                 605             
Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val
    610                 615                 620                 
Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp
625                 630                 635                 640 
Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro
                645                 650                 655     
Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys
            660                 665                 670         
Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala
        675                 680                 685         


<210> 6190
<211> 548
<212> PRT
<213> Homo sapiens

<400> 6190
Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr
 1               5                  10                  15      
Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val
            20                  25                  30          
Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg
        35                  40                  45              
Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly
    50                  55                  60                  
Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg
65                  70                  75                  80  
Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln
                85                  90                  95      
Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile
            100                 105                 110         
Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser
        115                 120                 125             
Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro
    130                 135                 140                 
Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val
145                 150                 155                 160 
Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys
                165                 170                 175     
Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile
            180                 185                 190         
Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly
        195                 200                 205             
Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val
    210                 215                 220                 
Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg
225                 230                 235                 240 
Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly
                245                 250                 255     
Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val
            260                 265                 270         
Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu
        275                 280                 285             
Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala
    290                 295                 300                 
His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe
305                 310                 315                 320 
Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys
                325                 330                 335     
Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu
            340                 345                 350         
Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr
        355                 360                 365             
Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu
    370                 375                 380                 
Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp
385                 390                 395                 400 
Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile
                405                 410                 415     
Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly
            420                 425                 430         
Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly
        435                 440                 445             
Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys
    450                 455                 460                 
Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly
465                 470                 475                 480 
Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr
                485                 490                 495     
Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg
            500                 505                 510         
Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr
        515                 520                 525             
Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Gly Lys Ala Leu Cys Ser
    530                 535                 540                 
Trp Ser Ile Cys
545             


<210> 6191
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 6191
Met Ser Gly Met Gly Glu Asn Thr Ser Asp Pro Ser Arg Ala Glu Thr
 1               5                  10                  15      
Arg Lys Arg Lys Glu Cys Pro Asp Gln Leu Gly Pro Ser Pro Lys Arg
            20                  25                  30          
Asn Thr Glu Lys Arg Asn Arg Glu Gln Glu Asn Lys Tyr Ile Glu Glu
        35                  40                  45              
Leu Ala Glu Leu Ile Phe Ala Asn Phe Asn Asp Ile Asp Asn Phe Asn
    50                  55                  60                  
Phe Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Lys Gln Ile
65                  70                  75                  80  
Arg Gln Ile Lys Glu Gln Glu Lys Ala Ala Ala Ala Asn Ile Asp Glu
                85                  90                  95      
Val Gln Lys Ser Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys
            100                 105                 110         
Asp Ala Leu Gly Pro Met Met Leu Glu Ala Leu Asp Gly Phe Phe Phe
        115                 120                 125             
Val Val Asn Leu Glu Gly Asn Val Val Phe Val Ser Glu Asn Val Thr
    130                 135                 140                 
Gln Tyr Leu Arg Tyr Asn Gln Glu Glu Leu Met Asn Lys Ser Val Tyr
145                 150                 155                 160 
Ser Ile Leu His Val Gly Asp His Thr Glu Phe Val Lys Asn Leu Leu
                165                 170                 175     
Pro Lys Ser Ile Val Asn Gly Gly Ser Trp Ser Gly Glu Pro Pro Arg
            180                 185                 190         
Arg Asn Ser His Thr Phe Asn Cys Arg Met Leu Val Lys Pro Leu Pro
        195                 200                 205             
Asp Ser Glu Glu Glu Gly His Asp Asn Gln Glu Ala His Gln Lys Tyr
    210                 215                 220                 
Glu Thr Met Gln Cys Phe Ala Val Ser Gln Pro Lys Ser Ile Lys Glu
225                 230                 235                 240 
Glu Gly Glu Asp Leu Gln Ser Cys Leu Ile Cys Val Ala Arg Arg Val
                245                 250                 255     
Pro Met Lys Glu Arg Pro Val Leu Pro Ser Ser Glu Ser Phe Thr Thr
            260                 265                 270         
Arg Gln Asp Leu Gln Gly Lys Ile Thr Ser Leu Asp Thr Ser Thr Met
        275                 280                 285             
Arg Ala Ala Met Lys Pro Gly Trp Glu Asp Leu Val Arg Arg Cys Ile
    290                 295                 300                 
Gln Lys Phe His Ala Gln His Glu Gly Glu Ser Val Ser Tyr Ala Lys
305                 310                 315                 320 
Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln Ile
                325                 330                 335     
Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr Lys
            340                 345                 350         
Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val Ile
        355                 360                 365             
Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn Pro
    370                 375                 380                 
Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser Ser
385                 390                 395                 400 
Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln Asp
                405                 410                 415     
Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys Glu
            420                 425                 430         
Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met Asn
        435                 440                 445             
His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr Ala
    450                 455                 460                 
Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro Gly
465                 470                 475                 480 
Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly Val
                485                 490                 495     
Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly Ser
            500                 505                 510         
Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His Ser
        515                 520                 525             
Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly His
    530                 535                 540                 
Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met Gly
545                 550                 555                 560 
Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser Lys
                565                 570                 575     
Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu Pro
            580                 585                 590         
Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly Glu
        595                 600                 605             
Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser Glu
    610                 615                 620                 
Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr Lys
625                 630                 635                 640 
Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser Pro
                645                 650                 655     
Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser Leu
            660                 665                 670         
Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His Lys
        675                 680                 685             
Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu Ala
    690                 695                 700                 
Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser Ser
705                 710                 715                 720 
Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val Ser
                725                 730                 735     
Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys Asp
            740                 745                 750         
Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu Arg
        755                 760                 765             
Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala Met
    770                 775                 780                 
Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro Gly
785                 790                 795                 800 
Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn Ser
                805                 810                 815     
Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala Gly
            820                 825                 830         
Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr Ala
        835                 840                 845             
Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu Arg
    850                 855                 860                 
Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly Arg
865                 870                 875                 880 
Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser Pro
                885                 890                 895     
Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr Ser
            900                 905                 910         
Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly Asn
        915                 920                 925             
Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser Ala
    930                 935                 940                 
Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser Ala
945                 950                 955                 960 
Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro Val
                965                 970                 975     
Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg Pro
            980                 985                 990         
Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met Asn
        995                 1000                1005            
Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro Gln Tyr Ser
    1010                1015                1020                
Gln Gln Gln Ala Pro Pro Asn Gln Thr Ala Pro Trp Pro Glu Ser Ile
1025                1030                1035                1040
Leu Pro Ile Asp Gln Ala Ser Phe Ala Ser Gln Asn Arg Gln Pro Phe
                1045                1050                1055    
Gly Ser Ser Pro Asp Asp Leu Leu Cys Pro His Pro Ala Ala Glu Ser
            1060                1065                1070        
Pro Ser Asp Glu Gly Ala Leu Leu Asp Gln Leu Tyr Leu Ala Leu Arg
        1075                1080                1085            
Asn Phe Asp Gly Leu Glu Glu Ile Asp Arg Ala Leu Gly Ile Pro Glu
    1090                1095                1100                
Leu Val Ser Gln Ser Gln Ala Val Asp Pro Glu Gln Phe Ser Ser Gln
1105                1110                1115                1120
Asp Ser Asn Ile Met Leu Glu Gln Lys Ala Pro Val Phe Pro Gln Gln
                1125                1130                1135    
Tyr Ala Ser Gln Ala Gln Met Ala Gln Gly Ser Tyr Ser Pro Met Gln
            1140                1145                1150        
Asp Pro Asn Phe His Thr Met Gly Gln Arg Pro Ser Tyr Ala Thr Leu
        1155                1160                1165            
Arg Met Gln Pro Arg Pro Gly Leu Arg Pro Thr Gly Leu Val Gln Asn
    1170                1175                1180                
Gln Pro Asn Gln Leu Arg Leu Gln Leu Gln His Arg Leu Gln Ala Gln
1185                1190                1195                1200
Gln Asn Arg Gln Pro Leu Met Asn Gln Ile Ser Asn Val Ser Asn Val
                1205                1210                1215    
Asn Leu Thr Leu Arg Pro Gly Val Pro Thr Gln Ala Pro Ile Asn Ala
            1220                1225                1230        
Gln Met Leu Ala Gln Arg Gln Arg Glu Ile Leu Asn Gln His Leu Arg
        1235                1240                1245            
Gln Arg Gln Met His Gln Gln Gln Gln Val Gln Gln Arg Thr Leu Met
    1250                1255                1260                
Met Arg Gly Gln Gly Leu Asn Met Thr Pro Ser Met Val Ala Pro Ser
1265                1270                1275                1280
Gly Met Pro Ala Thr Met Ser Asn Pro Arg Ile Pro Gln Ala Asn Ala
                1285                1290                1295    
Gln Gln Phe Pro Phe Pro Pro Asn Tyr Gly Ile Ser Gln Gln Pro Asp
            1300                1305                1310        
Pro Gly Phe Thr Gly Ala Thr Thr Pro Gln Ser Pro Leu Met Ser Pro
        1315                1320                1325            
Arg Met Ala His Thr Gln Ser Pro Met Met Gln Gln Ser Gln Ala Asn
    1330                1335                1340                
Pro Ala Tyr Gln Ala Pro Ser Asp Ile Asn Gly Trp Ala Gln Gly Asn
1345                1350                1355                1360
Met Gly Gly Asn Ser Met Phe Ser Gln Gln Ser Pro Pro His Phe Gly
                1365                1370                1375    
Gln Gln Ala Asn Thr Ser Met Tyr Ser Asn Asn Met Asn Ile Asn Val
            1380                1385                1390        
Ser Met Ala Thr Asn Thr Gly Gly Met Ser Ser Met Asn Gln Met Thr
        1395                1400                1405            
Gly Gln Ile Ser Met Thr Ser Val Thr Ser Val Pro Thr Ser Gly Leu
    1410                1415                1420                
Ser Ser Met Gly Pro Glu Gln Val Asn Asp Pro Ala Leu Arg Gly Gly
1425                1430                1435                1440
Asn Leu Phe Pro Asn Gln Leu Pro Gly Met Asp Met Ile Lys Gln Glu
                1445                1450                1455    
Gly Asp Thr Thr Arg Lys Tyr Cys
            1460                


<210> 6192
<211> 495
<212> PRT
<213> Homo sapiens

<400> 6192
Met Asp Pro Thr Ala Leu Val Glu Ala Ile Val Glu Glu Val Ala Cys
 1               5                  10                  15      
Pro Ile Cys Met Thr Phe Leu Arg Glu Pro Met Ser Ile Asp Cys Gly
            20                  25                  30          
His Ser Phe Cys His Ser Cys Leu Ser Gly Leu Trp Glu Ile Pro Gly
        35                  40                  45              
Glu Ser Gln Asn Trp Gly Tyr Thr Cys Pro Leu Cys Arg Ala Pro Val
    50                  55                  60                  
Gln Pro Arg Asn Leu Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu
65                  70                  75                  80  
Lys Val Arg Leu Leu Arg Leu His Pro Gly Met Gly Leu Lys Gly Asp
                85                  90                  95      
Leu Cys Glu Arg His Gly Glu Lys Leu Lys Met Phe Cys Lys Glu Asp
            100                 105                 110         
Val Leu Ile Met Cys Glu Ala Cys Ser Gln Ser Pro Glu His Glu Ala
        115                 120                 125             
His Ser Val Val Pro Met Glu Asp Val Ala Trp Glu Tyr Lys Trp Glu
    130                 135                 140                 
Leu His Glu Ala Leu Glu His Leu Lys Lys Glu Gln Glu Glu Ala Trp
145                 150                 155                 160 
Lys Leu Glu Val Gly Glu Arg Lys Arg Thr Ala Thr Trp Lys Ala Val
                165                 170                 175     
Leu Ile Ser Ile Leu Ala Pro Gln Ile Gln Val Glu Thr Arg Lys Gln
            180                 185                 190         
Ser Ile Val Trp Glu Phe Glu Lys Tyr Gln Arg Leu Leu Glu Lys Lys
        195                 200                 205             
Gln Pro Pro His Arg Gln Leu Gly Ala Glu Val Ala Ala Ala Leu Ala
    210                 215                 220                 
Ser Leu Gln Arg Glu Ala Ala Glu Thr Met Gln Lys Leu Glu Leu Asn
225                 230                 235                 240 
His Ser Glu Leu Ile Gln Gln Ser Gln Val Leu Trp Arg Met Ile Ala
                245                 250                 255     
Glu Leu Lys Glu Arg Ser Gln Arg Pro Val Arg Trp Met Leu Gln Asp
            260                 265                 270         
Ile Gln Glu Val Leu Asn Arg Ser Lys Ser Trp Ser Leu Gln Gln Pro
        275                 280                 285             
Glu Pro Ile Ser Leu Glu Leu Lys Thr Asp Cys Arg Val Leu Gly Leu
    290                 295                 300                 
Arg Glu Ile Leu Lys Thr Tyr Ala Ala Asp Val Arg Leu Asp Pro Asp
305                 310                 315                 320 
Thr Ala Tyr Ser Arg Leu Ile Val Ser Glu Asp Arg Lys Arg Val His
                325                 330                 335     
Tyr Gly Asp Thr Asn Gln Lys Leu Pro Asp Asn Pro Glu Arg Phe Tyr
            340                 345                 350         
Arg Tyr Asn Ile Val Leu Gly Ser Gln Cys Ile Ser Ser Gly Arg His
        355                 360                 365             
Tyr Trp Glu Val Glu Val Gly Asp Arg Ser Glu Trp Gly Leu Gly Val
    370                 375                 380                 
Cys Lys Gln Asn Val Asp Arg Lys Glu Val Val Tyr Leu Ser Pro His
385                 390                 395                 400 
Tyr Gly Phe Trp Val Ile Arg Leu Arg Lys Gly Asn Glu Tyr Arg Ala
                405                 410                 415     
Gly Thr Asp Glu Tyr Pro Ile Leu Ser Leu Pro Val Pro Pro Arg Arg
            420                 425                 430         
Val Gly Ile Phe Val Asp Tyr Glu Ala His Asp Ile Ser Phe Tyr Asn
        435                 440                 445             
Val Thr Asp Cys Gly Ser His Ile Phe Thr Phe Pro Arg Tyr Pro Phe
    450                 455                 460                 
Pro Gly Arg Leu Leu Pro Tyr Phe Ser Pro Cys Tyr Ser Ile Gly Thr
465                 470                 475                 480 
Asn Asn Thr Ala Pro Leu Ala Ile Cys Ser Leu Asp Gly Glu Asp
                485                 490                 495 


<210> 6193
<211> 175
<212> PRT
<213> Homo sapiens

<400> 6193
Met Pro Lys Ser Cys Ala Ala Arg Gln Cys Cys Asn Arg Tyr Ser Ser
 1               5                  10                  15      
Arg Arg Lys Gln Leu Thr Phe His Arg Phe Pro Phe Ser Arg Pro Glu
            20                  25                  30          
Leu Leu Lys Glu Trp Val Leu Asn Ile Gly Arg Gly Asn Phe Lys Pro
        35                  40                  45              
Lys Gln His Thr Val Ile Cys Ser Glu His Phe Arg Pro Glu Cys Phe
    50                  55                  60                  
Ser Ala Phe Gly Asn Arg Lys Asn Leu Lys His Asn Ala Val Pro Thr
65                  70                  75                  80  
Val Phe Ala Phe Gln Asp Pro Thr Gln Gln Val Arg Glu Asn Thr Asp
                85                  90                  95      
Pro Ala Ser Glu Arg Gly Asn Ala Ser Ser Ser Gln Lys Glu Lys Thr
            100                 105                 110         
Ser Pro Cys Arg Ser Gln Val Leu Pro Glu Ala Gly Ala Gly Glu Asp
        115                 120                 125             
Ser Pro Gly Arg Asn Met Asp Thr Ala Leu Glu Glu Leu Gln Leu Pro
    130                 135                 140                 
Pro Asn Ala Glu Gly His Val Lys Gln Ala Met Leu Phe Asn Val Glu
145                 150                 155                 160 
Asn Gly Thr Pro Ala Ser Arg Glu Ala Leu Trp Leu Ser Glu Glu
                165                 170                 175 


<210> 6194
<211> 287
<212> PRT
<213> Homo sapiens

<400> 6194
Met Ala Leu Val Ala Pro Asp Glu Met Glu Lys Ile Asn Asn Pro Leu
 1               5                  10                  15      
Tyr Ser Arg Gln Gly Glu Val Leu Ala Ser Arg Lys Asp Phe Arg Met
            20                  25                  30          
Asn Thr Cys Val Pro His Pro Arg Arg Ala Phe Met Leu Glu Pro Glu
        35                  40                  45              
Gly Met Ser Pro Met Glu Pro Ala Gly Val Ser Pro Met Pro Gly Thr
    50                  55                  60                  
Gln Asn Asp Thr Gly Arg Thr Glu Glu Gln Pro Met Glu Val Ser Val
65                  70                  75                  80  
Cys Arg Ser Pro Val Pro Ala Leu Gly Phe Ser Gln Glu Pro Gly Pro
                85                  90                  95      
Ser Pro Glu Arg Pro Met Pro Leu Gly Gly Gly Glu Asp Glu Asp Ala
            100                 105                 110         
Glu Glu Ala Val Glu Leu Pro Glu Ala Ser Ala Pro Lys Ala Ala Leu
        115                 120                 125             
Glu Pro Lys Glu Ser Arg Ser Pro Gln Gln Ser Ala Ala Leu Pro Arg
    130                 135                 140                 
Arg Tyr Met Leu Arg Glu Arg Glu Gly Ala Pro Glu Pro Ala Ser Cys
145                 150                 155                 160 
Val Lys Glu Thr Pro Asp Leu Trp Gln Ser Leu Asp Pro Leu Asn Ser
                165                 170                 175     
Leu Glu Ser Lys Pro Phe Lys Lys Gly Arg Pro Tyr Ser Val Pro Pro
            180                 185                 190         
Cys Val Glu Glu Ala Leu Gly Gln Lys Arg Lys Arg Lys Gly Ala Ala
        195                 200                 205             
Lys Leu Gln Asp Phe His Gln Trp Tyr Leu Val Ala Tyr Ala Asp His
    210                 215                 220                 
Ala Asp Ser Arg Arg Leu Arg Arg Lys Gly Pro Ser Phe Ala Asp Met
225                 230                 235                 240 
Glu Val Leu Tyr Trp Thr His Val Lys Glu Gln Leu Glu Thr Leu Arg
                245                 250                 255     
Lys Leu Gln Arg Arg Glu Val Ala Glu Gln Trp Leu Arg Pro Ala Glu
            260                 265                 270         
Glu Asp His Leu Glu Asp Ser Pro Gly Arg Pro Gly Gly Ser Arg
        275                 280                 285         


<210> 6195
<211> 1156
<212> PRT
<213> Homo sapiens

<400> 6195
Met Phe Pro Ala Ala Pro Ser Pro Arg Thr Pro Gly Thr Gly Ser Arg
 1               5                  10                  15      
Arg Gly Pro Leu Ala Gly Leu Gly Pro Gly Ser Thr Pro Arg Thr Ala
            20                  25                  30          
Ser Arg Lys Gly Leu Pro Leu Gly Ser Ala Val Ser Ser Pro Val Leu
        35                  40                  45              
Phe Ser Pro Val Gly Arg Arg Ser Ser Leu Ser Ser Arg Gly Thr Pro
    50                  55                  60                  
Thr Arg Met Phe Pro His His Ser Ile Thr Glu Ser Val Asn Tyr Asp
65                  70                  75                  80  
Val Lys Thr Phe Gly Ser Ser Leu Pro Val Lys Val Met Glu Ala Leu
                85                  90                  95      
Thr Leu Ala Glu Val Asp Asp Gln Leu Thr Ile Asn Ile Asp Glu Gly
            100                 105                 110         
Gly Trp Ala Cys Leu Val Cys Lys Glu Lys Leu Ile Ile Trp Lys Ile
        115                 120                 125             
Ala Leu Ser Pro Ile Thr Lys Leu Ser Val Cys Lys Glu Leu Gln Leu
    130                 135                 140                 
Pro Pro Ser Asp Phe His Trp Ser Ala Asp Leu Val Ala Leu Ser Tyr
145                 150                 155                 160 
Ser Ser Pro Ser Gly Glu Ala His Ser Thr Gln Ala Val Ala Val Met
                165                 170                 175     
Val Ala Thr Arg Glu Gly Ser Ile Arg Tyr Trp Pro Ser Leu Ala Gly
            180                 185                 190         
Glu Asp Thr Tyr Thr Glu Ala Phe Val Asp Ser Gly Gly Asp Lys Thr
        195                 200                 205             
Tyr Ser Phe Leu Thr Ala Val Gln Gly Gly Ser Phe Ile Leu Ser Ser
    210                 215                 220                 
Ser Gly Ser Gln Leu Ile Arg Leu Ile Pro Glu Ser Ser Gly Lys Ile
225                 230                 235                 240 
His Gln His Ile Leu Pro Gln Gly Gln Gly Met Leu Ser Gly Ile Gly
                245                 250                 255     
Arg Lys Val Ser Ser Leu Phe Gly Ile Leu Ser Pro Ser Ser Asp Leu
            260                 265                 270         
Thr Leu Ser Ser Val Leu Trp Asp Arg Glu Arg Ser Ser Phe Tyr Ser
        275                 280                 285             
Leu Thr Ser Ser Asn Ile Ser Lys Trp Glu Leu Asp Asp Ser Ser Glu
    290                 295                 300                 
Lys His Ala Tyr Ser Trp Asp Ile Asn Arg Ala Leu Lys Glu Asn Ile
305                 310                 315                 320 
Thr Asp Ala Ile Trp Gly Ser Glu Ser Asn Tyr Glu Ala Ile Lys Glu
                325                 330                 335     
Gly Val Asn Ile Arg Tyr Leu Asp Phe Lys Gln Asn Cys Asp Gly Leu
            340                 345                 350         
Val Ile Leu Ala Ala Ala Trp His Ser Ala Asp Asn Pro Cys Leu Ile
        355                 360                 365             
Tyr Tyr Ser Leu Ile Thr Ile Glu Asp Asn Gly Cys Gln Met Ser Asp
    370                 375                 380                 
Ala Val Thr Val Glu Val Thr Gln Tyr Asn Pro Pro Phe Gln Ser Glu
385                 390                 395                 400 
Asp Leu Ile Leu Cys Gln Leu Thr Val Pro Asn Phe Ser Asn Gln Thr
                405                 410                 415     
Ala Tyr Leu Tyr Asn Glu Ser Ala Val Tyr Val Cys Ser Thr Gly Thr
            420                 425                 430         
Gly Lys Phe Ser Leu Pro Gln Glu Lys Ile Val Phe Asn Ala Gln Gly
        435                 440                 445             
Asp Ser Val Leu Gly Ala Gly Ala Cys Gly Gly Val Pro Ile Ile Phe
    450                 455                 460                 
Ser Arg Asn Ser Gly Leu Val Ser Ile Thr Ser Arg Glu Asn Val Ser
465                 470                 475                 480 
Ile Leu Ala Glu Asp Leu Glu Gly Ser Leu Ala Ser Ser Val Ala Gly
                485                 490                 495     
Pro Asn Ser Glu Ser Met Ile Phe Glu Thr Thr Thr Lys Asn Glu Thr
            500                 505                 510         
Ile Ala Gln Glu Asp Lys Ile Lys Leu Leu Lys Ala Ala Phe Leu Gln
        515                 520                 525             
Tyr Cys Arg Lys Asp Leu Gly His Ala Gln Met Val Val Asp Glu Leu
    530                 535                 540                 
Phe Ser Ser His Ser Asp Leu Asp Ser Asp Ser Glu Leu Asp Arg Ala
545                 550                 555                 560 
Val Thr Gln Ile Ser Val Asp Leu Met Asp Asp Tyr Pro Ala Ser Asp
                565                 570                 575     
Pro Arg Trp Ala Glu Ser Val Pro Glu Glu Ala Pro Gly Phe Ser Asn
            580                 585                 590         
Thr Ser Leu Ile Ile Leu His Gln Leu Glu Asp Lys Met Lys Ala His
        595                 600                 605             
Ser Phe Leu Met Asp Phe Ile His Gln Val Gly Leu Phe Gly Arg Leu
    610                 615                 620                 
Gly Ser Phe Pro Val Arg Gly Thr Pro Met Ala Thr Arg Leu Leu Leu
625                 630                 635                 640 
Cys Glu His Ala Glu Lys Leu Ser Ala Ala Ile Val Leu Lys Asn His
                645                 650                 655     
His Ser Arg Leu Ser Asp Leu Val Asn Thr Ala Ile Leu Ile Ala Leu
            660                 665                 670         
Asn Lys Arg Glu Tyr Glu Ile Pro Ser Asn Leu Thr Pro Ala Asp Val
        675                 680                 685             
Phe Phe Arg Glu Val Ser Gln Val Asp Thr Ile Cys Glu Cys Leu Leu
    690                 695                 700                 
Glu His Glu Glu Gln Val Leu Arg Asp Ala Pro Met Asp Ser Ile Glu
705                 710                 715                 720 
Trp Ala Glu Val Val Ile Asn Val Asn Asn Ile Leu Lys Asp Met Leu
                725                 730                 735     
Gln Ala Ala Ser His Tyr Arg Gln Asn Arg Asn Ser Leu Tyr Arg Arg
            740                 745                 750         
Glu Glu Ser Leu Glu Lys Glu Pro Glu Tyr Val Pro Trp Thr Ala Thr
        755                 760                 765             
Ser Gly Pro Gly Gly Ile Arg Thr Val Ile Ile Arg Gln His Glu Ile
    770                 775                 780                 
Val Leu Lys Val Ala Tyr Pro Gln Ala Asp Ser Asn Leu Arg Asn Ile
785                 790                 795                 800 
Val Thr Glu Gln Leu Val Ala Leu Ile Asp Cys Phe Leu Asp Gly Tyr
                805                 810                 815     
Val Ser Gln Leu Lys Ser Val Asp Lys Ser Ser Asn Arg Glu Arg Tyr
            820                 825                 830         
Asp Asn Leu Glu Met Glu Tyr Leu Gln Lys Arg Ser Asp Leu Leu Ser
        835                 840                 845             
Pro Leu Leu Ser Leu Gly Gln Tyr Leu Trp Ala Ala Ser Leu Ala Glu
    850                 855                 860                 
Lys Tyr Cys Asp Phe Asp Ile Leu Val Gln Met Cys Glu Gln Thr Asp
865                 870                 875                 880 
Asn Gln Ser Arg Leu Gln Arg Tyr Met Thr Gln Phe Ala Asp Gln Asn
                885                 890                 895     
Phe Ser Asp Phe Leu Phe Arg Trp Tyr Leu Glu Lys Gly Lys Arg Gly
            900                 905                 910         
Lys Leu Leu Ser Gln Pro Ile Ser Gln His Gly Gln Leu Ala Asn Phe
        915                 920                 925             
Leu Gln Ala His Glu His Leu Ser Trp Leu His Glu Ile Asn Ser Gln
    930                 935                 940                 
Glu Leu Glu Lys Ala His Ala Thr Leu Leu Gly Leu Ala Asn Met Glu
945                 950                 955                 960 
Thr Arg Tyr Phe Ala Lys Lys Lys Thr Leu Leu Gly Leu Ser Lys Leu
                965                 970                 975     
Ala Ala Leu Ala Ser Asp Phe Ser Glu Asp Met Leu Gln Glu Lys Ile
            980                 985                 990         
Glu Glu Met Ala Glu Gln Glu Arg Phe Leu Leu His Gln Glu Thr Leu
        995                 1000                1005            
Pro Glu Gln Leu Leu Ala Glu Lys Gln Leu Asn Leu Ser Ala Met Pro
    1010                1015                1020                
Val Leu Thr Ala Pro Gln Leu Ile Gly Leu Tyr Ile Cys Glu Glu Asn
1025                1030                1035                1040
Arg Arg Ala Asn Glu Tyr Asp Phe Lys Lys Ala Leu Asp Leu Leu Glu
                1045                1050                1055    
Tyr Ile Asp Glu Glu Glu Asp Ile Asn Ile Asn Asp Leu Lys Leu Glu
            1060                1065                1070        
Ile Leu Cys Lys Ala Leu Gln Arg Asp Asn Trp Ser Ser Ser Asp Gly
        1075                1080                1085            
Lys Asp Asp Pro Ile Glu Val Ser Lys Asp Ser Ile Phe Val Lys Ile
    1090                1095                1100                
Leu Gln Lys Leu Leu Lys Asp Gly Ile Gln Leu Ser Glu Tyr Leu Pro
1105                1110                1115                1120
Glu Val Lys Asp Leu Leu Gln Ala Asp Gln Leu Gly Ser Leu Lys Ser
                1125                1130                1135    
Asn Pro Tyr Phe Glu Phe Val Leu Lys Ala Asn Tyr Glu Tyr Tyr Val
            1140                1145                1150        
Gln Gly Gln Ile
        1155    


<210> 6196
<211> 1376
<212> PRT
<213> Homo sapiens

<400> 6196
Met Phe Arg Ala Gly Glu Ala Ser Lys Arg Pro Leu Pro Gly Pro Ser
 1               5                  10                  15      
Pro Pro Arg Val Arg Ser Val Glu Val Ala Arg Gly Arg Ala Gly Tyr
            20                  25                  30          
Gly Phe Thr Leu Ser Gly Gln Ala Pro Cys Val Leu Ser Cys Val Met
        35                  40                  45              
Arg Gly Ser Pro Ala Asp Phe Val Gly Leu Arg Ala Gly Asp Gln Ile
    50                  55                  60                  
Leu Ala Val Asn Glu Ile Asn Val Lys Lys Ala Ser His Glu Asp Val
65                  70                  75                  80  
Val Lys Leu Ile Gly Lys Cys Ser Gly Val Leu His Met Val Ile Ala
                85                  90                  95      
Glu Gly Val Gly Arg Phe Glu Ser Cys Ser Ser Asp Glu Glu Gly Gly
            100                 105                 110         
Leu Tyr Glu Gly Lys Gly Trp Leu Lys Pro Lys Leu Asp Ser Lys Ala
        115                 120                 125             
Leu Gly Ile Asn Arg Ala Glu Arg Val Val Glu Glu Met Gln Ser Gly
    130                 135                 140                 
Gly Ile Phe Asn Met Ile Phe Glu Asn Pro Ser Leu Cys Ala Ser Asn
145                 150                 155                 160 
Ser Glu Pro Leu Lys Leu Lys Gln Arg Ser Leu Ser Glu Ser Ala Ala
                165                 170                 175     
Thr Arg Phe Asp Val Gly His Glu Ser Ile Asn Asn Pro Asn Pro Asn
            180                 185                 190         
Met Leu Ser Lys Glu Glu Ile Ser Lys Val Ile His Asp Asp Ser Val
        195                 200                 205             
Phe Ser Ile Gly Leu Glu Ser His Asp Asp Phe Ala Leu Asp Ala Ser
    210                 215                 220                 
Ile Leu Asn Val Ala Met Ile Val Gly Tyr Leu Gly Ser Ile Glu Leu
225                 230                 235                 240 
Pro Ser Thr Ser Ser Asn Leu Glu Ser Asp Ser Leu Gln Ala Ile Arg
                245                 250                 255     
Gly Cys Met Arg Arg Leu Arg Ala Glu Gln Lys Ile His Ser Leu Val
            260                 265                 270         
Thr Met Lys Ile Met His Asp Cys Val Gln Leu Ser Thr Asp Lys Ala
        275                 280                 285             
Gly Val Val Ala Glu Tyr Pro Ala Glu Lys Leu Ala Phe Ser Ala Val
    290                 295                 300                 
Cys Pro Asp Asp Arg Arg Phe Phe Gly Leu Val Thr Met Gln Thr Asn
305                 310                 315                 320 
Asp Asp Gly Ser Leu Ala Gln Glu Glu Glu Gly Ala Leu Arg Thr Ser
                325                 330                 335     
Cys His Val Phe Met Val Asp Pro Asp Leu Phe Asn His Lys Ile His
            340                 345                 350         
Gln Gly Ile Ala Arg Arg Phe Gly Phe Glu Cys Thr Ala Asp Pro Asp
        355                 360                 365             
Thr Asn Gly Cys Leu Glu Phe Pro Ala Ser Ser Leu Pro Val Leu Gln
    370                 375                 380                 
Phe Ile Ser Val Leu Tyr Arg Asp Met Gly Glu Leu Ile Glu Gly Met
385                 390                 395                 400 
Arg Ala Arg Ala Phe Leu Asp Gly Asp Ala Asp Ala His Gln Asn Asn
                405                 410                 415     
Ser Thr Ser Ser Asn Ser Asp Ser Gly Ile Gly Asn Phe His Gln Glu
            420                 425                 430         
Glu Lys Ser Asn Arg Val Leu Val Val Asp Leu Gly Gly Ser Ser Ser
        435                 440                 445             
Arg His Gly Pro Gly Gly Ser Ala Trp Asp Gly Val Gly Gly Arg Gly
    450                 455                 460                 
Ala Gln Pro Trp Gly Ala Pro Trp Thr Gly Pro Phe Cys Pro Asp Pro
465                 470                 475                 480 
Glu Gly Ser Pro Pro Phe Glu Ala Ala His Gln Thr Asp Arg Phe Trp
                485                 490                 495     
Asp Leu Asn Lys His Leu Gly Pro Ala Ser Pro Val Glu Val Pro Pro
            500                 505                 510         
Ala Ser Leu Arg Ser Ser Val Pro Pro Ser Lys Arg Gly Thr Val Gly
        515                 520                 525             
Ala Gly Cys Gly Phe Asn Gln Arg Trp Leu Pro Val His Val Leu Arg
    530                 535                 540                 
Glu Trp Gln Cys Gly His Thr Ser Asp Gln Asp Ser Tyr Thr Asp Ser
545                 550                 555                 560 
Thr Asp Gly Trp Ser Ser Ile Asn Cys Gly Thr Leu Pro Pro Pro Met
                565                 570                 575     
Ser Lys Ile Pro Ala Asp Arg Tyr Arg Val Glu Gly Ser Phe Ala Gln
            580                 585                 590         
Pro Pro Leu Asn Ala Pro Lys Arg Glu Trp Ser Arg Lys Ala Phe Gly
        595                 600                 605             
Met Gln Ser Ile Phe Gly Pro His Arg Asn Val Arg Lys Thr Lys Glu
    610                 615                 620                 
Asp Lys Lys Gly Ser Lys Phe Gly Arg Gly Thr Gly Leu Thr Gln Pro
625                 630                 635                 640 
Ser Gln Arg Thr Ser Ala Arg Arg Ser Phe Gly Arg Ser Lys Arg Phe
                645                 650                 655     
Ser Ile Thr Arg Ser Leu Asp Asp Leu Glu Ser Ala Thr Val Ser Asp
            660                 665                 670         
Gly Glu Leu Thr Gly Ala Asp Leu Lys Asp Cys Val Ser Asn Asn Ser
        675                 680                 685             
Leu Ser Ser Asn Ala Ser Leu Pro Ser Val Gln Ser Cys Arg Arg Leu
    690                 695                 700                 
Arg Glu Arg Arg Val Ala Ser Trp Ala Val Ser Phe Glu Arg Leu Leu
705                 710                 715                 720 
Gln Asp Pro Val Gly Val Arg Tyr Phe Ser Asp Phe Leu Arg Lys Glu
                725                 730                 735     
Phe Ser Glu Glu Asn Ile Leu Phe Trp Gln Ala Cys Glu Tyr Phe Asn
            740                 745                 750         
His Val Pro Ala His Asp Lys Lys Glu Leu Ser Tyr Arg Ala Arg Glu
        755                 760                 765             
Ile Phe Ser Lys Phe Leu Cys Ser Lys Ala Thr Thr Pro Val Asn Ile
    770                 775                 780                 
Asp Ser Gln Ala Gln Leu Ala Asp Asp Val Leu Arg Ala Pro His Pro
785                 790                 795                 800 
Asp Met Phe Lys Glu Gln Gln Leu Gln Ile Phe Asn Leu Met Lys Phe
                805                 810                 815     
Asp Ser Tyr Thr Arg Phe Leu Lys Ser Pro Leu Tyr Gln Glu Cys Ile
            820                 825                 830         
Leu Ala Glu Val Glu Gly Arg Ala Leu Pro Asp Ser Gln Gln Val Pro
        835                 840                 845             
Ser Ser Pro Ala Ser Lys His Ser Leu Gly Ser Asp His Ser Ser Val
    850                 855                 860                 
Ser Thr Pro Lys Lys Leu Ser Gly Lys Ser Lys Ser Gly Arg Ser Leu
865                 870                 875                 880 
Asn Glu Glu Leu Gly Asp Glu Asp Ser Glu Lys Lys Arg Lys Gly Ala
                885                 890                 895     
Phe Phe Ser Trp Ser Arg Thr Arg Ser Thr Gly Arg Ser Gln Lys Lys
            900                 905                 910         
Arg Glu His Gly Asp His Ala Asp Asp Ala Leu His Ala Asn Gly Gly
        915                 920                 925             
Leu Cys Arg Arg Glu Ser Gln Gly Ser Val Ser Ser Ala Gly Ser Leu
    930                 935                 940                 
Asp Leu Ser Glu Ala Cys Arg Thr Leu Ala Pro Glu Lys Asp Lys Ala
945                 950                 955                 960 
Thr Lys His Cys Cys Ile His Leu Pro Asp Gly Thr Ser Cys Val Val
                965                 970                 975     
Ala Val Lys Ala Gly Phe Ser Ile Lys Asp Ile Leu Ser Gly Leu Cys
            980                 985                 990         
Glu Arg His Gly Ile Asn Gly Ala Ala Ala Asp Leu Phe Leu Val Gly
        995                 1000                1005            
Gly Asp Lys Pro Leu Val Leu His Gln Asp Ser Ser Ile Leu Glu Ser
    1010                1015                1020                
Arg Asp Leu Arg Leu Glu Lys Arg Thr Leu Phe Arg Leu Asp Leu Val
1025                1030                1035                1040
Pro Ile Asn Arg Ser Val Gly Leu Lys Ala Lys Pro Thr Lys Pro Val
                1045                1050                1055    
Thr Glu Val Leu Arg Pro Val Val Ala Arg Tyr Gly Leu Asp Leu Ser
            1060                1065                1070        
Gly Leu Leu Val Arg Leu Ser Gly Glu Lys Glu Pro Leu Asp Leu Gly
        1075                1080                1085            
Ala Pro Ile Ser Ser Leu Asp Gly Gln Arg Val Val Leu Glu Glu Lys
    1090                1095                1100                
Asp Pro Ser Arg Gly Lys Ala Ser Ala Asp Lys Gln Lys Gly Val Pro
1105                1110                1115                1120
Val Lys Gln Asn Thr Ala Val Asn Ser Ser Ser Arg Asn His Ser Ala
                1125                1130                1135    
Thr Gly Glu Glu Arg Thr Leu Gly Lys Ser Asn Ser Ile Lys Ile Lys
            1140                1145                1150        
Gly Glu Asn Gly Lys Asn Ala Arg Asp Pro Arg Leu Ser Lys Arg Glu
        1155                1160                1165            
Glu Ser Ile Ala Lys Ile Gly Lys Lys Lys Tyr Gln Lys Ile Asn Leu
    1170                1175                1180                
Asp Glu Ala Glu Glu Phe Phe Glu Leu Ile Ser Lys Ala Gln Ser Asn
1185                1190                1195                1200
Arg Ala Asp Asp Gln Arg Gly Leu Leu Arg Lys Glu Asp Leu Val Leu
                1205                1210                1215    
Pro Glu Phe Leu Arg Leu Pro Pro Gly Ser Thr Glu Leu Thr Leu Pro
            1220                1225                1230        
Thr Pro Ala Ala Val Ala Lys Gly Phe Ser Lys Arg Ser Ala Thr Gly
        1235                1240                1245            
Asn Gly Arg Glu Ser Ala Ser Gln Pro Gly Glu Gln Trp Glu Pro Val
    1250                1255                1260                
Gln Glu Ser Ser Asp Ser Pro Ser Thr Ser Pro Gly Ser Ala Ser Ser
1265                1270                1275                1280
Pro Pro Gly Pro Pro Gly Thr Thr Pro Pro Gly Gln Lys Ser Pro Ser
                1285                1290                1295    
Gly Pro Phe Cys Thr Pro Gln Ser Pro Val Ser Leu Ala Gln Glu Gly
            1300                1305                1310        
Thr Ala Gln Ile Trp Lys Arg Gln Ser Gln Glu Val Glu Ala Gly Gly
        1315                1320                1325            
Ile Gln Thr Val Glu Asp Glu His Val Ala Glu Leu Thr Leu Met Gly
    1330                1335                1340                
Glu Gly Asp Ile Ser Ser Pro Asn Ser Thr Leu Leu Pro Pro Pro Ser
1345                1350                1355                1360
Thr Pro Gln Glu Val Pro Gly Pro Ser Arg Pro Gly Thr Ser Arg Phe
                1365                1370                1375    


<210> 6197
<211> 1447
<212> PRT
<213> Homo sapiens

<400> 6197
Met Phe Arg Ala Gly Glu Ala Ser Lys Arg Pro Leu Pro Gly Pro Ser
 1               5                  10                  15      
Pro Pro Arg Val Arg Ser Val Glu Val Ala Arg Gly Arg Ala Gly Tyr
            20                  25                  30          
Gly Phe Thr Leu Ser Gly Gln Ala Pro Cys Val Leu Ser Cys Val Met
        35                  40                  45              
Arg Gly Ser Pro Ala Asp Phe Val Gly Leu Arg Ala Gly Asp Gln Ile
    50                  55                  60                  
Leu Ala Val Asn Glu Ile Asn Val Lys Lys Ala Ser His Glu Asp Val
65                  70                  75                  80  
Val Lys Leu Ile Gly Lys Cys Ser Gly Val Leu His Met Val Ile Ala
                85                  90                  95      
Glu Gly Val Gly Arg Phe Glu Ser Cys Ser Ser Asp Glu Glu Gly Gly
            100                 105                 110         
Leu Tyr Glu Gly Lys Gly Trp Leu Lys Pro Lys Leu Asp Ser Lys Ala
        115                 120                 125             
Leu Gly Ile Asn Arg Ala Glu Arg Val Val Glu Glu Met Gln Ser Gly
    130                 135                 140                 
Gly Ile Phe Asn Met Ile Phe Glu Asn Pro Ser Leu Cys Ala Ser Asn
145                 150                 155                 160 
Ser Glu Pro Leu Lys Leu Lys Gln Arg Ser Leu Ser Glu Ser Ala Ala
                165                 170                 175     
Thr Arg Phe Asp Val Gly His Glu Ser Ile Asn Asn Pro Asn Pro Asn
            180                 185                 190         
Met Leu Ser Lys Glu Glu Ile Ser Lys Val Ile His Asp Asp Ser Val
        195                 200                 205             
Phe Ser Ile Gly Leu Glu Ser His Asp Asp Phe Ala Leu Asp Ala Ser
    210                 215                 220                 
Ile Leu Asn Val Ala Met Ile Val Gly Tyr Leu Gly Ser Ile Glu Leu
225                 230                 235                 240 
Pro Ser Thr Ser Ser Asn Leu Glu Ser Asp Ser Leu Gln Ala Ile Arg
                245                 250                 255     
Gly Cys Met Arg Arg Leu Arg Ala Glu Gln Lys Ile His Ser Leu Val
            260                 265                 270         
Thr Met Lys Ile Met His Asp Cys Val Gln Leu Ser Thr Asp Lys Ala
        275                 280                 285             
Gly Val Val Ala Glu Tyr Pro Ala Glu Lys Leu Ala Phe Ser Ala Val
    290                 295                 300                 
Cys Pro Asp Asp Arg Arg Phe Phe Gly Leu Val Thr Met Gln Thr Asn
305                 310                 315                 320 
Asp Asp Gly Ser Leu Ala Gln Glu Glu Glu Gly Ala Leu Arg Thr Ser
                325                 330                 335     
Cys His Val Phe Met Val Asp Pro Asp Leu Phe Asn His Lys Ile His
            340                 345                 350         
Gln Gly Ile Ala Arg Arg Phe Gly Phe Glu Cys Thr Ala Asp Pro Asp
        355                 360                 365             
Thr Asn Gly Cys Leu Glu Phe Pro Ala Ser Ser Leu Pro Val Leu Gln
    370                 375                 380                 
Phe Ile Ser Val Leu Tyr Arg Asp Met Gly Glu Leu Ile Glu Gly Met
385                 390                 395                 400 
Arg Ala Arg Ala Phe Leu Asp Gly Asp Ala Asp Ala His Gln Asn Asn
                405                 410                 415     
Ser Thr Ser Ser Asn Ser Asp Ser Gly Ile Gly Asn Phe His Gln Glu
            420                 425                 430         
Glu Lys Ser Asn Arg Val Leu Val Val Asp Leu Gly Gly Ser Ser Ser
        435                 440                 445             
Arg His Gly Pro Gly Gly Ser Ala Trp Asp Gly Val Gly Gly Arg Gly
    450                 455                 460                 
Ala Gln Pro Trp Gly Ala Pro Trp Thr Gly Pro Phe Cys Pro Asp Pro
465                 470                 475                 480 
Glu Gly Ser Pro Pro Phe Glu Ala Ala His Gln Thr Asp Arg Phe Trp
                485                 490                 495     
Asp Leu Asn Lys His Leu Gly Pro Ala Ser Pro Val Glu Val Pro Pro
            500                 505                 510         
Ala Ser Leu Arg Ser Ser Val Pro Pro Ser Lys Arg Gly Thr Val Gly
        515                 520                 525             
Ala Gly Cys Gly Phe Asn Gln Arg Trp Leu Pro Val His Val Leu Arg
    530                 535                 540                 
Glu Trp Gln Cys Gly His Thr Ser Asp Gln Asp Ser Tyr Thr Asp Ser
545                 550                 555                 560 
Thr Asp Gly Trp Ser Ser Ile Asn Cys Gly Thr Leu Pro Pro Pro Met
                565                 570                 575     
Ser Lys Ile Pro Ala Asp Arg Tyr Arg Val Glu Gly Ser Phe Ala Gln
            580                 585                 590         
Pro Pro Leu Asn Ala Pro Lys Arg Glu Trp Ser Arg Lys Ala Phe Gly
        595                 600                 605             
Met Gln Ser Ile Phe Gly Pro His Arg Asn Val Arg Lys Thr Lys Glu
    610                 615                 620                 
Asp Lys Lys Gly Ser Lys Phe Gly Arg Gly Thr Gly Leu Thr Gln Pro
625                 630                 635                 640 
Ser Gln Arg Thr Ser Ala Arg Arg Ser Phe Gly Arg Ser Lys Arg Phe
                645                 650                 655     
Ser Ile Thr Arg Ser Leu Asp Asp Leu Glu Ser Ala Thr Val Ser Asp
            660                 665                 670         
Gly Glu Leu Thr Gly Ala Asp Leu Lys Asp Cys Val Ser Asn Asn Ser
        675                 680                 685             
Leu Ser Ser Asn Ala Ser Leu Pro Ser Val Gln Ser Cys Arg Arg Leu
    690                 695                 700                 
Arg Glu Arg Arg Val Ala Ser Trp Ala Val Ser Phe Glu Arg Leu Leu
705                 710                 715                 720 
Gln Asp Pro Val Gly Val Arg Tyr Phe Ser Asp Phe Leu Arg Lys Glu
                725                 730                 735     
Phe Ser Glu Glu Asn Ile Leu Phe Trp Gln Ala Cys Glu Tyr Phe Asn
            740                 745                 750         
His Val Pro Ala His Asp Lys Lys Glu Leu Ser Tyr Arg Ala Arg Glu
        755                 760                 765             
Ile Phe Ser Lys Phe Leu Cys Ser Lys Ala Thr Thr Pro Val Asn Ile
    770                 775                 780                 
Asp Ser Gln Ala Gln Leu Ala Asp Asp Val Leu Arg Ala Pro His Pro
785                 790                 795                 800 
Asp Met Phe Lys Glu Gln Gln Leu Gln Ile Phe Asn Leu Met Lys Phe
                805                 810                 815     
Asp Ser Tyr Thr Arg Phe Leu Lys Ser Pro Leu Tyr Gln Glu Cys Ile
            820                 825                 830         
Leu Ala Glu Val Glu Gly Arg Ala Leu Pro Asp Ser Gln Gln Val Pro
        835                 840                 845             
Ser Ser Pro Ala Ser Lys His Ser Leu Gly Ser Asp His Ser Ser Val
    850                 855                 860                 
Ser Thr Pro Lys Lys Leu Ser Gly Lys Ser Lys Ser Gly Arg Ser Leu
865                 870                 875                 880 
Asn Glu Glu Leu Gly Asp Glu Asp Ser Glu Lys Lys Arg Lys Gly Ala
                885                 890                 895     
Phe Phe Ser Trp Ser Arg Thr Arg Ser Thr Gly Arg Ser Gln Lys Lys
            900                 905                 910         
Arg Glu His Gly Asp His Ala Asp Asp Ala Leu His Ala Asn Gly Gly
        915                 920                 925             
Leu Cys Arg Arg Glu Ser Gln Gly Ser Val Ser Ser Ala Gly Ser Leu
    930                 935                 940                 
Asp Leu Ser Glu Ala Cys Arg Thr Leu Ala Pro Glu Lys Asp Lys Ala
945                 950                 955                 960 
Thr Lys His Cys Cys Ile His Leu Pro Asp Gly Thr Ser Cys Val Val
                965                 970                 975     
Ala Val Lys Ala Gly Phe Ser Ile Lys Asp Ile Leu Ser Gly Leu Cys
            980                 985                 990         
Glu Arg His Gly Ile Asn Gly Ala Ala Ala Asp Leu Phe Leu Val Gly
        995                 1000                1005            
Gly Asp Lys Pro Leu Val Leu His Gln Asp Ser Ser Ile Leu Glu Ser
    1010                1015                1020                
Arg Asp Leu Arg Leu Glu Lys Arg Thr Leu Phe Arg Leu Asp Leu Val
1025                1030                1035                1040
Pro Ile Asn Arg Ser Val Gly Leu Lys Ala Lys Pro Thr Lys Pro Val
                1045                1050                1055    
Thr Glu Val Leu Arg Pro Val Val Ala Arg Tyr Gly Leu Asp Leu Ser
            1060                1065                1070        
Gly Leu Leu Val Arg Leu Ser Gly Glu Lys Glu Pro Leu Asp Leu Gly
        1075                1080                1085            
Ala Pro Ile Ser Ser Leu Asp Gly Gln Arg Val Val Leu Glu Glu Lys
    1090                1095                1100                
Asp Pro Ser Arg Gly Lys Ala Ser Ala Asp Lys Gln Lys Gly Val Pro
1105                1110                1115                1120
Val Lys Gln Asn Thr Ala Val Asn Ser Ser Ser Arg Asn His Ser Ala
                1125                1130                1135    
Thr Gly Glu Glu Arg Thr Leu Gly Lys Ser Asn Ser Ile Lys Ile Lys
            1140                1145                1150        
Gly Glu Asn Gly Lys Asn Ala Arg Asp Pro Arg Leu Ser Lys Arg Glu
        1155                1160                1165            
Glu Ser Ile Ala Lys Ile Gly Lys Lys Lys Tyr Gln Lys Ile Asn Leu
    1170                1175                1180                
Asp Glu Ala Glu Glu Phe Phe Glu Leu Ile Ser Lys Ala Gln Ser Asn
1185                1190                1195                1200
Arg Ala Asp Asp Gln Arg Gly Leu Leu Arg Lys Glu Asp Leu Val Leu
                1205                1210                1215    
Pro Glu Phe Leu Arg Leu Pro Pro Gly Ser Thr Glu Leu Thr Leu Pro
            1220                1225                1230        
Thr Pro Ala Ala Val Ala Lys Gly Phe Ser Lys Arg Ser Ala Thr Gly
        1235                1240                1245            
Asn Gly Arg Glu Ser Ala Ser Gln Pro Gly Glu Gln Trp Glu Pro Val
    1250                1255                1260                
Gln Glu Ser Ser Asp Ser Pro Ser Thr Ser Pro Gly Ser Ala Ser Ser
1265                1270                1275                1280
Pro Pro Gly Pro Pro Gly Thr Thr Pro Pro Gly Gln Lys Ser Pro Ser
                1285                1290                1295    
Gly Pro Phe Cys Thr Pro Gln Ser Pro Val Ser Leu Ala Gln Glu Gly
            1300                1305                1310        
Thr Ala Gln Ile Trp Lys Arg Gln Ser Gln Glu Val Glu Ala Gly Gly
        1315                1320                1325            
Ile Gln Thr Val Glu Asp Glu His Val Ala Glu Leu Thr Leu Met Gly
    1330                1335                1340                
Glu Gly Asp Ile Ser Ser Pro Asn Ser Thr Leu Leu Pro Pro Pro Ser
1345                1350                1355                1360
Thr Pro Gln Glu Val Pro Gly Pro Ser Arg Pro Gly Ser Gly Thr His
                1365                1370                1375    
Gly Ser Arg Asp Leu Pro Val Asn Arg Ile Ile Asp Val Asp Leu Val
            1380                1385                1390        
Thr Gly Ser Ala Pro Gly Arg Asp Gly Gly Ile Ala Gly Ala Gln Ala
        1395                1400                1405            
Gly Pro Gly Arg Ser Gln Ala Ser Gly Gly Pro Pro Thr Ser Asp Leu
    1410                1415                1420                
Pro Gly Leu Gly Pro Val Pro Gly Glu Pro Ala Lys Pro Lys Thr Ser
1425                1430                1435                1440
Ala His His Ala Thr Phe Val
                1445        


<210> 6198
<211> 679
<212> PRT
<213> Homo sapiens

<400> 6198
Met Phe Arg Ala Gly Glu Ala Ser Lys Arg Pro Leu Pro Gly Pro Ser
 1               5                  10                  15      
Pro Pro Arg Val Arg Ser Val Glu Val Ala Arg Gly Arg Ala Gly Tyr
            20                  25                  30          
Gly Phe Thr Leu Ser Gly Gln Ala Pro Cys Val Leu Ser Cys Val Met
        35                  40                  45              
Arg Gly Ser Pro Ala Asp Phe Val Gly Leu Arg Ala Gly Asp Gln Ile
    50                  55                  60                  
Leu Ala Val Asn Glu Ile Asn Val Lys Lys Ala Ser His Glu Asp Val
65                  70                  75                  80  
Val Lys Leu Ile Gly Lys Cys Ser Gly Val Leu His Met Val Ile Ala
                85                  90                  95      
Glu Gly Val Gly Arg Phe Glu Ser Cys Ser Ser Asp Glu Glu Gly Gly
            100                 105                 110         
Leu Tyr Glu Gly Lys Gly Trp Leu Lys Pro Lys Leu Asp Ser Lys Ala
        115                 120                 125             
Leu Gly Ile Asn Arg Ala Glu Arg Val Val Glu Glu Met Gln Ser Gly
    130                 135                 140                 
Gly Ile Phe Asn Met Ile Phe Glu Asn Pro Ser Leu Cys Ala Ser Asn
145                 150                 155                 160 
Ser Glu Pro Leu Lys Leu Lys Gln Arg Ser Leu Ser Glu Ser Ala Ala
                165                 170                 175     
Thr Arg Phe Asp Val Gly His Glu Ser Ile Asn Asn Pro Asn Pro Asn
            180                 185                 190         
Met Leu Ser Lys Glu Glu Ile Ser Lys Val Ile His Asp Asp Ser Val
        195                 200                 205             
Phe Ser Ile Gly Leu Glu Ser His Asp Asp Phe Ala Leu Asp Ala Ser
    210                 215                 220                 
Ile Leu Asn Val Ala Met Ile Val Gly Tyr Leu Gly Ser Ile Glu Leu
225                 230                 235                 240 
Pro Ser Thr Ser Ser Asn Leu Glu Ser Asp Ser Leu Gln Ala Ile Arg
                245                 250                 255     
Gly Cys Met Arg Arg Leu Arg Ala Glu Gln Lys Ile His Ser Leu Val
            260                 265                 270         
Thr Met Lys Ile Met His Asp Cys Val Gln Leu Ser Thr Asp Lys Ala
        275                 280                 285             
Gly Val Val Ala Glu Tyr Pro Ala Glu Lys Leu Ala Phe Ser Ala Val
    290                 295                 300                 
Cys Pro Asp Asp Arg Arg Phe Phe Gly Leu Val Thr Met Gln Thr Asn
305                 310                 315                 320 
Asp Asp Gly Ser Leu Ala Gln Glu Glu Glu Gly Ala Leu Arg Thr Ser
                325                 330                 335     
Cys His Val Phe Met Val Asp Pro Asp Leu Phe Asn His Lys Ile His
            340                 345                 350         
Gln Gly Ile Ala Arg Arg Phe Gly Phe Glu Cys Thr Ala Asp Pro Asp
        355                 360                 365             
Thr Asn Gly Cys Leu Glu Phe Pro Ala Ser Ser Leu Pro Val Leu Gln
    370                 375                 380                 
Phe Ile Ser Val Leu Tyr Arg Asp Met Gly Glu Leu Ile Glu Gly Met
385                 390                 395                 400 
Arg Ala Arg Ala Phe Leu Asp Gly Asp Ala Asp Ala His Gln Asn Asn
                405                 410                 415     
Ser Thr Ser Ser Asn Ser Asp Ser Gly Ile Gly Asn Phe His Gln Glu
            420                 425                 430         
Glu Lys Ser Asn Arg Val Leu Val Val Asp Leu Gly Gly Ser Ser Ser
        435                 440                 445             
Arg His Gly Pro Gly Gly Ser Ala Trp Asp Gly Val Gly Gly Arg Gly
    450                 455                 460                 
Ala Gln Pro Trp Gly Ala Pro Trp Thr Gly Pro Phe Cys Pro Asp Pro
465                 470                 475                 480 
Glu Gly Ser Pro Pro Phe Glu Ala Ala His Gln Thr Asp Arg Phe Trp
                485                 490                 495     
Asp Leu Asn Lys His Leu Gly Pro Ala Ser Pro Val Glu Val Pro Pro
            500                 505                 510         
Ala Ser Leu Arg Ser Ser Val Pro Pro Ser Lys Arg Gly Thr Val Gly
        515                 520                 525             
Ala Gly Cys Gly Phe Asn Gln Arg Trp Leu Pro Val His Val Leu Arg
    530                 535                 540                 
Glu Trp Gln Cys Gly His Thr Ser Asp Gln Asp Ser Tyr Thr Asp Ser
545                 550                 555                 560 
Thr Asp Gly Trp Ser Ser Ile Asn Cys Gly Thr Leu Pro Pro Pro Met
                565                 570                 575     
Ser Lys Ile Pro Ala Asp Arg Tyr Arg Val Glu Gly Ser Phe Ala Gln
            580                 585                 590         
Pro Pro Leu Asn Ala Pro Lys Arg Glu Trp Ser Arg Lys Ala Phe Gly
        595                 600                 605             
Met Gln Ser Ile Phe Gly Pro His Arg Asn Val Arg Lys Thr Lys Glu
    610                 615                 620                 
Asp Lys Lys Gly Ser Lys Phe Gly Arg Gly Thr Gly Leu Thr Gln Pro
625                 630                 635                 640 
Ser Gln Arg Thr Ser Ala Arg Arg Ser Phe Gly Arg Ser Lys Arg Phe
                645                 650                 655     
Ser Ile Thr Arg Ser Leu Asp Asp Leu Glu Trp Ser Thr Cys Ala Arg
            660                 665                 670         
Arg Cys Gly Asn Gly Tyr Pro
        675                 


<210> 6199
<211> 540
<212> PRT
<213> Homo sapiens

<400> 6199
Met Thr Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp
 1               5                  10                  15      
Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Gly Tyr Val
            20                  25                  30          
Glu Arg Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly
        35                  40                  45              
Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys
    50                  55                  60                  
Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu
65                  70                  75                  80  
Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys
                85                  90                  95      
Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Asp Ile Thr Gln Asp
            100                 105                 110         
Leu Val Asp Glu Ser Glu Glu Glu Arg Phe Asp Asp Met Ser Ser Pro
        115                 120                 125             
Gly Leu Glu Leu Pro Ser Cys Glu Leu Ser Arg Leu Glu Glu Ile Ala
    130                 135                 140                 
Glu Leu Val Ala Ser Ser Leu Pro Ser Pro Leu Arg Arg Glu Lys Leu
145                 150                 155                 160 
Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu Glu Leu
                165                 170                 175     
Phe His Val Cys Glu Asp Leu Glu Asn Ile Glu Gly Leu His His Leu
            180                 185                 190         
Tyr Glu Ile Ile Lys Gly Ile Phe Leu Leu Asn Arg Thr Ala Leu Phe
        195                 200                 205             
Glu Val Met Phe Ser Glu Glu Cys Ile Met Asp Val Ile Gly Cys Leu
    210                 215                 220                 
Glu Tyr Asp Pro Ala Leu Ser Gln Pro Arg Lys His Arg Glu Phe Leu
225                 230                 235                 240 
Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Ser Asp Pro Glu
                245                 250                 255     
Leu Lys Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile Gln Asp
            260                 265                 270         
Met Val Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Met Leu Ser Thr
        275                 280                 285             
Leu His Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Gly Met Leu
    290                 295                 300                 
Gln Glu Asp Glu Lys Phe Leu Thr Asp Leu Phe Ala Gln Leu Thr Asp
305                 310                 315                 320 
Glu Ala Thr Asp Glu Glu Lys Arg Gln Glu Leu Val Asn Phe Leu Lys
                325                 330                 335     
Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg Asp Ala
            340                 345                 350         
Phe Phe Lys Thr Leu Ser Asn Met Gly Ile Leu Pro Ala Leu Glu Val
        355                 360                 365             
Ile Leu Gly Met Asp Asp Thr Gln Val Arg Ser Ala Ala Thr Asp Ile
    370                 375                 380                 
Phe Ser Tyr Leu Val Glu Tyr Asn Pro Ser Met Val Arg Glu Phe Val
385                 390                 395                 400 
Met Gln Glu Ala Gln Gln Asn Asp Asp Asp Ile Leu Leu Ile Asn Leu
                405                 410                 415     
Ile Ile Glu His Met Ile Cys Asp Thr Asp Pro Glu Leu Gly Gly Ala
            420                 425                 430         
Val Gln Leu Met Gly Leu Leu Arg Thr Leu Val Asp Pro Glu Asn Met
        435                 440                 445             
Leu Ala Thr Ala Asn Lys Thr Glu Lys Thr Glu Phe Leu Gly Phe Phe
    450                 455                 460                 
Tyr Lys His Cys Met His Val Leu Thr Ala Pro Leu Leu Ala Asn Thr
465                 470                 475                 480 
Thr Glu Asp Lys Pro Ser Lys Asp Asp Phe Gln Thr Ala Gln Leu Leu
                485                 490                 495     
Ala Leu Val Leu Glu Leu Leu Thr Phe Cys Val Glu His His Thr Tyr
            500                 505                 510         
His Ile Lys Asn Tyr Ile Ile Asn Lys Asp Ile Leu Arg Arg Val Leu
        515                 520                 525             
Val Leu Met Ala Ser Lys His Ala Phe Leu Ala Leu
    530                 535                 540 


<210> 6200
<211> 392
<212> PRT
<213> Homo sapiens

<400> 6200
Met Val Arg Ser Gly Lys Asn Gly Asp Leu His Leu Lys Gln Ile Ala
 1               5                  10                  15      
Tyr Tyr Lys Arg Thr Gly Glu Tyr His Ser Thr Thr Leu Pro Ser Glu
            20                  25                  30          
Arg Ser Gly Ile Arg Arg Ala Ala Lys Lys Phe Val Phe Lys Glu Lys
        35                  40                  45              
Lys Leu Phe Tyr Val Gly Lys Asp Arg Lys Gln Asn Arg Leu Val Ile
    50                  55                  60                  
Val Ser Glu Glu Glu Lys Lys Lys Val Leu Arg Glu Cys His Glu Asn
65                  70                  75                  80  
Asp Ser Gly Ala His His Gly Ile Ser Arg Thr Leu Thr Leu Val Glu
                85                  90                  95      
Ser Asn Tyr Tyr Trp Thr Ser Val Thr Asn Asp Ala Lys Gln Trp Val
            100                 105                 110         
Tyr Ala Cys Gln His Cys Gln Val Ala Lys Asn Thr Val Ile Val Ala
        115                 120                 125             
Pro Lys Gln His Leu Leu Lys Val Glu Asn Pro Trp Ser Leu Val Thr
    130                 135                 140                 
Val Asp Leu Met Gly Pro Phe His Thr Ser Asn Arg Ser His Val Tyr
145                 150                 155                 160 
Ala Ile Ile Met Thr Asp Leu Phe Thr Lys Trp Ile Val Ile Leu Pro
                165                 170                 175     
Leu Cys Asp Val Ser Ala Ser Glu Val Ser Lys Ala Ile Ile Asn Ile
            180                 185                 190         
Phe Phe Leu Tyr Gly Pro Pro Gln Lys Ile Ile Met Asp Gln Arg Asp
        195                 200                 205             
Glu Phe Ile Gln Gln Ile Asn Ile Glu Leu Tyr Arg Leu Phe Gly Ile
    210                 215                 220                 
Lys Gln Ile Val Ile Ser His Thr Ser Gly Thr Val Asn Pro Met Glu
225                 230                 235                 240 
Ser Thr Pro Asn Thr Ile Lys Ala Phe Leu Ser Lys His Cys Ala Asp
                245                 250                 255     
His Pro Asn Asn Trp Asp Asp His Leu Ser Ala Val Ser Phe Ala Phe
            260                 265                 270         
Asn Val Thr His Leu Glu Pro Thr Lys Asn Thr Pro Tyr Phe Gln Met
        275                 280                 285             
Phe Ser Arg Asn Pro Tyr Met Pro Glu Thr Ser Asp Ser Leu His Glu
    290                 295                 300                 
Val Asp Gly Asp Asn Thr Ser Met Phe Ala Lys Ile Leu Asp Ala Ile
305                 310                 315                 320 
Lys Glu Ala Asp Lys Ile Met Glu Asn Lys Thr Thr Ser Leu Gly Gln
                325                 330                 335     
Met Glu Asn Asn Asn Leu Asp Glu Leu Asn Lys Ser Lys Ile Ile Val
            340                 345                 350         
Lys Lys Lys Pro Lys Gln Leu Asn Pro Phe His Leu Lys Val Gly His
        355                 360                 365             
Glu Val Leu Arg Gln Arg Lys Ile Gly Gly Arg Met Val Val Phe Ser
    370                 375                 380                 
Leu Asn Gly Leu Val Leu Val Ser
385                 390         


<210> 6201
<211> 634
<212> PRT
<213> Homo sapiens

<400> 6201
Phe Gln Gly Leu Val Met Phe Gln Asp Leu Ser Ile Asp Phe Ser Gln
 1               5                  10                  15      
Glu Glu Trp Glu Cys Leu Asp Ala Ala Gln Lys Asp Leu Tyr Arg Asp
            20                  25                  30          
Val Met Met Glu Asn Tyr Ser Ser Leu Val Ser Leu Glu Thr His Thr
        35                  40                  45              
Gly Glu Lys Leu Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe His His
    50                  55                  60                  
Phe Ser Tyr Leu Val Lys His Gln Arg Ile His Thr Gly Glu Lys Pro
65                  70                  75                  80  
Cys Ala Cys Lys Glu Tyr Gly Lys Ala Phe Ile Ser Gly Ser His Leu
                85                  90                  95      
Ile Gln His Gln Lys Met Tyr Thr Asp Glu Arg Pro His Glu Cys Gln
            100                 105                 110         
Glu Ser Val Lys Ala Phe Arg Pro Ser Ala His Leu Ile Gln His Trp
        115                 120                 125             
Arg Ile His Thr Gly Asp Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys
    130                 135                 140                 
Ser Phe Thr Ser Gly Ser Thr Leu Asn Gln His Gln Gln Ile His Thr
145                 150                 155                 160 
Gly Glu Lys Pro Tyr His Cys Lys Gln Cys Gly Lys Ser Phe Thr Val
                165                 170                 175     
Gly Ser Thr Leu Ile Arg His Gln Gln Ile His Thr Gly Glu Lys Pro
            180                 185                 190         
Tyr Asp Trp Leu Ile Gly His Gln Ala Ile His Thr Gly Glu Lys Pro
        195                 200                 205             
Tyr Asp Cys Lys Glu Cys Gly Lys Ser Phe Thr Ala Gly Ser Thr Leu
    210                 215                 220                 
Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Asp Cys Lys
225                 230                 235                 240 
Glu Cys Gly Lys Ser Phe Ala Ser Gly Ser Ala Leu Leu Gln His Gln
                245                 250                 255     
Arg Ile His Thr Gly Glu Lys Pro Tyr Cys Cys Lys Glu Cys Gly Lys
            260                 265                 270         
Ser Phe Thr Phe Arg Ser Thr Arg Asn Arg His Gln Arg Ile His Thr
        275                 280                 285             
Gly Glu Lys Pro Tyr Asn Cys Lys Glu Cys Gly Lys Ser Phe Ala Ser
    290                 295                 300                 
Gly Ser Ala Leu Leu Gln His Gln Arg Ile His Thr Gly Glu Lys Pro
305                 310                 315                 320 
Tyr His Cys Lys Glu Cys Gly Lys Ser Phe Thr Phe Arg Ser Gly Leu
                325                 330                 335     
Ile Gly His Gln Ala Val His Thr Gly Glu Lys Pro Tyr Asp Cys Lys
            340                 345                 350         
Glu Cys Gly Lys Ser Phe Thr Ser Arg Ser Ala Leu Ile Gln His Gln
        355                 360                 365             
Arg Ile His Thr Gly Glu Lys Pro Tyr His Cys Lys Glu Cys Gly Lys
    370                 375                 380                 
Ser Phe Thr Val Gly Ser Thr Leu Leu Gln His Gln Gln Ile His Thr
385                 390                 395                 400 
Gly Glu Lys Pro Tyr Asp Cys Lys Glu Cys Gly Lys Ala Phe Arg Leu
                405                 410                 415     
Arg Leu Arg Leu Thr Gln His Gln Gln Ile His Thr Gly Glu Lys Pro
            420                 425                 430         
Tyr Gln Cys Gln Glu Cys Gly Lys Ala Phe Val Ser Val Ser Gly Leu
        435                 440                 445             
Thr Gln His His Arg Ile His Thr Val His Thr Gly Glu Lys Arg Tyr
    450                 455                 460                 
Ser Cys Lys Glu Cys Gly Lys Ser Phe Thr Ser Arg Ser Thr Leu Ile
465                 470                 475                 480 
Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr His Cys Lys Glu
                485                 490                 495     
Cys Gly Lys Ser Phe Ala Phe Arg Ser Ala Ile Ile Gln His Arg Arg
            500                 505                 510         
Ile His Thr Gly Glu Lys Pro Tyr Asp Cys Lys Glu Cys Gly Lys Ala
        515                 520                 525             
Phe Arg Arg Arg Ser Lys Leu Thr Gln His Gln Arg Ile His Thr Gly
    530                 535                 540                 
Glu Lys Pro Tyr Arg Cys His Glu Cys Gly Lys Ala Phe Val Arg Phe
545                 550                 555                 560 
Ser Gly Leu Thr Lys His His Ser Ile His Thr Gly Glu Lys Pro Tyr
                565                 570                 575     
Glu Cys Lys Thr Cys Gly Lys Ser Phe Arg Gln Arg Thr His Leu Thr
            580                 585                 590         
Leu His Gln Arg Ile His Thr Gly Asp Arg Pro Tyr Glu Cys Lys Glu
        595                 600                 605             
Cys Gly Lys Ser Phe Thr Cys Gly Ser Glu Leu Ile Arg His Gln Arg
    610                 615                 620                 
Thr His Thr Gly Glu Lys Pro Tyr Asp Cys
625                 630                 


<210> 6202
<211> 510
<212> PRT
<213> Homo sapiens

<400> 6202
Met Pro Gly Gly Gly Ala Ser Ala Ala Ser Gly Arg Leu Leu Thr Ala
 1               5                  10                  15      
Ala Glu Gln Arg Gly Ser Arg Glu Ala Ala Gly Ser Ala Ser Arg Ser
            20                  25                  30          
Gly Phe Gly Gly Ser Gly Gly Gly Arg Gly Gly Ala Ser Gly Pro Gly
        35                  40                  45              
Ser Gly Ser Gly Gly Pro Gly Gly Pro Ala Gly Arg Met Ser Leu Thr
    50                  55                  60                  
Pro Lys Glu Leu Ser Ser Leu Leu Ser Ile Ile Ser Glu Glu Ala Gly
65                  70                  75                  80  
Gly Gly Ser Thr Phe Glu Gly Leu Ser Thr Ala Phe His His Tyr Phe
                85                  90                  95      
Ser Lys Ala Asp His Phe Arg Leu Gly Ser Val Leu Val Met Leu Leu
            100                 105                 110         
Gln Gln Pro Asp Leu Leu Pro Ser Ala Ala Gln Arg Leu Thr Ala Leu
        115                 120                 125             
Tyr Leu Leu Trp Glu Met Tyr Arg Thr Glu Pro Leu Ala Ala Asn Pro
    130                 135                 140                 
Phe Ala Ala Ser Phe Ala His Leu Leu Asn Pro Ala Pro Pro Ala Arg
145                 150                 155                 160 
Gly Gly Gln Glu Pro Asp Arg Pro Pro Leu Ser Gly Phe Leu Pro Pro
                165                 170                 175     
Ile Thr Pro Pro Glu Lys Phe Phe Leu Ser Gln Leu Met Leu Ala Pro
            180                 185                 190         
Pro Arg Glu Leu Phe Lys Lys Thr Pro Arg Gln Ile Ala Leu Met Asp
        195                 200                 205             
Val Gly Asn Met Gly Gln Ser Val Asp Ile Ser Gly Leu Gln Leu Ala
    210                 215                 220                 
Leu Ala Glu Arg Gln Ser Glu Leu Pro Thr Gln Ser Lys Ala Ser Phe
225                 230                 235                 240 
Pro Ser Ile Leu Ser Asp Pro Asp Pro Asp Ser Ser Asn Ser Gly Phe
                245                 250                 255     
Asp Ser Ser Val Ala Ser Gln Ile Thr Glu Ala Leu Val Ser Gly Pro
            260                 265                 270         
Lys Pro Pro Ile Glu Ser His Phe Arg Pro Glu Phe Ile Arg Pro Pro
        275                 280                 285             
Pro Pro Leu His Ile Cys Glu Asp Glu Leu Ala Trp Leu Asn Pro Thr
    290                 295                 300                 
Glu Pro Asp His Ala Ile Gln Trp Asp Lys Ser Met Cys Val Lys Asn
305                 310                 315                 320 
Ser Thr Gly Val Glu Ile Lys Arg Ile Met Ala Lys Ala Phe Lys Ser
                325                 330                 335     
Pro Leu Ser Ser Pro Gln Gln Thr Gln Leu Leu Gly Glu Leu Glu Lys
            340                 345                 350         
Asp Pro Lys Leu Val Tyr His Ile Gly Leu Thr Pro Ala Lys Leu Pro
        355                 360                 365             
Asp Leu Val Glu Asn Asn Pro Leu Val Ala Ile Glu Met Leu Leu Lys
    370                 375                 380                 
Leu Met Gln Ser Ser Gln Ile Thr Glu Tyr Phe Ser Val Leu Val Asn
385                 390                 395                 400 
Met Asp Met Ser Leu His Ser Met Glu Val Val Asn Arg Leu Thr Thr
                405                 410                 415     
Ala Val Asp Leu Pro Pro Glu Phe Ile His Leu Tyr Ile Ser Asn Cys
            420                 425                 430         
Ile Ser Thr Cys Glu Gln Ile Lys Asp Lys Tyr Met Gln Asn Arg Leu
        435                 440                 445             
Val Arg Leu Val Cys Val Phe Leu Gln Ser Leu Ile Arg Asn Lys Ile
    450                 455                 460                 
Ile Asn Val Gln Asp Leu Phe Ile Glu Val Gln Ala Phe Cys Ile Glu
465                 470                 475                 480 
Phe Ser Arg Ile Arg Glu Ala Ala Gly Leu Phe Arg Leu Leu Lys Thr
                485                 490                 495     
Leu Asp Thr Gly Glu Thr Pro Ser Glu Thr Lys Met Ser Lys
            500                 505                 510 


<210> 6203
<211> 622
<212> PRT
<213> Homo sapiens

<400> 6203
Met Ala Glu Asn Thr Glu Gly Asp Leu Asn Ser Asn Leu Leu His Ala
 1               5                  10                  15      
Pro Tyr His Thr Gly Asp Pro Gln Leu Asp Thr Ala Ile Gly Gln Trp
            20                  25                  30          
Leu Arg Trp Asp Lys Asn Pro Lys Thr Lys Glu Gln Ile Glu Asn Leu
        35                  40                  45              
Leu Arg Asn Gly Met Asn Lys Glu Leu Arg Asp Arg Leu Cys Cys Arg
    50                  55                  60                  
Met Thr Phe Gly Ala Ala Gly Leu Arg Ser Ala Met Gly Ala Gly Phe
65                  70                  75                  80  
Cys Tyr Ile Asn Asp Leu Thr Val Ile Gln Ser Thr Gln Gly Met Tyr
                85                  90                  95      
Lys Tyr Leu Glu Arg Cys Phe Ser Asp Phe Lys Gln Arg Gly Phe Val
            100                 105                 110         
Val Gly Tyr Asp Thr Arg Gly Gln Val Thr Ser Ser Cys Ser Ser Gln
        115                 120                 125             
Arg Leu Ala Lys Leu Thr Ala Ala Val Leu Leu Ala Lys Asp Val Pro
    130                 135                 140                 
Val Tyr Leu Phe Ser Arg Tyr Val Pro Thr Pro Phe Val Pro Tyr Ala
145                 150                 155                 160 
Val Gln Lys Leu Lys Ala Val Ala Gly Val Met Ile Thr Ala Ser His
                165                 170                 175     
Asn Arg Lys Glu Asp Asn Gly Tyr Lys Val Tyr Trp Glu Thr Gly Ala
            180                 185                 190         
Gln Ile Thr Ser Pro His Asp Lys Glu Ile Leu Lys Cys Ile Glu Glu
        195                 200                 205             
Cys Val Glu Pro Trp Asn Gly Ser Trp Asn Asp Asn Leu Val Asp Thr
    210                 215                 220                 
Ser Pro Leu Lys Arg Asp Pro Leu Gln Asp Ile Cys Arg Arg Tyr Met
225                 230                 235                 240 
Glu Asp Leu Lys Lys Ile Cys Phe Tyr Arg Glu Leu Asn Ser Lys Thr
                245                 250                 255     
Thr Leu Lys Phe Val His Thr Ser Phe His Gly Val Gly His Asp Tyr
            260                 265                 270         
Val Gln Leu Ala Phe Lys Val Phe Gly Phe Lys Pro Pro Ile Pro Val
        275                 280                 285             
Pro Glu Gln Lys Asp Pro Asp Pro Asp Phe Ser Thr Val Lys Cys Pro
    290                 295                 300                 
Asn Pro Glu Glu Gly Glu Ser Val Leu Glu Leu Ser Leu Arg Leu Ala
305                 310                 315                 320 
Glu Lys Glu Asn Ala Arg Val Val Leu Ala Thr Asp Pro Asp Ala Asp
                325                 330                 335     
Arg Leu Ala Ala Ala Glu Leu Gln Glu Asn Gly Cys Trp Lys Val Phe
            340                 345                 350         
Thr Gly Asn Glu Leu Ala Ala Leu Phe Gly Trp Trp Met Phe Asp Cys
        355                 360                 365             
Trp Lys Lys Asn Lys Ser Arg Asn Ala Asp Val Lys Asn Val Tyr Met
    370                 375                 380                 
Leu Ala Thr Thr Val Ser Ser Lys Ile Leu Lys Ala Ile Ala Leu Lys
385                 390                 395                 400 
Glu Gly Phe His Phe Glu Glu Thr Leu Pro Gly Phe Lys Trp Ile Gly
                405                 410                 415     
Ser Arg Ile Ile Asp Leu Leu Glu Asn Gly Lys Glu Val Leu Phe Ala
            420                 425                 430         
Phe Glu Glu Ser Ile Gly Phe Leu Cys Gly Thr Ser Val Leu Asp Lys
        435                 440                 445             
Asp Gly Val Ser Ala Ala Val Val Val Ala Glu Met Ala Ser Tyr Leu
    450                 455                 460                 
Glu Thr Met Asn Ile Thr Leu Lys Gln Gln Leu Val Lys Val Tyr Glu
465                 470                 475                 480 
Lys Tyr Gly Tyr His Ile Ser Lys Thr Ser Tyr Phe Leu Cys Tyr Glu
                485                 490                 495     
Pro Pro Thr Ile Lys Ser Ile Phe Glu Arg Leu Arg Asn Phe Asp Ser
            500                 505                 510         
Pro Lys Glu Tyr Pro Lys Phe Cys Gly Thr Phe Ala Ile Leu His Val
        515                 520                 525             
Arg Asp Ile Thr Thr Gly Tyr Asp Ser Ser Gln Pro Asn Lys Lys Ser
    530                 535                 540                 
Val Leu Pro Val Ser Lys Asn Ser Gln Met Ile Thr Phe Thr Phe Gln
545                 550                 555                 560 
Asn Gly Cys Val Ala Thr Leu Arg Thr Ser Gly Thr Glu Pro Lys Ile
                565                 570                 575     
Lys Tyr Tyr Ala Glu Met Cys Ala Ser Pro Asp Gln Ser Asp Thr Ala
            580                 585                 590         
Leu Leu Glu Glu Glu Leu Lys Lys Leu Ile Asp Ala Leu Ile Glu Asn
        595                 600                 605             
Phe Leu Gln Pro Ser Lys Asn Gly Leu Ile Trp Arg Ser Val
    610                 615                 620         


<210> 6204
<211> 622
<212> PRT
<213> Homo sapiens

<400> 6204
Met Ala Glu Asn Thr Glu Gly Asp Leu Asn Ser Asn Leu Leu His Ala
 1               5                  10                  15      
Pro Tyr His Thr Gly Asp Pro Gln Leu Asp Thr Ala Ile Gly Gln Trp
            20                  25                  30          
Leu Arg Trp Asp Lys Asn Pro Lys Thr Lys Glu Gln Ile Glu Asn Leu
        35                  40                  45              
Leu Arg Asn Gly Met Asn Lys Glu Leu Arg Asp Arg Leu Cys Cys Arg
    50                  55                  60                  
Met Thr Phe Gly Thr Ala Gly Leu Arg Ser Ala Met Gly Ala Gly Phe
65                  70                  75                  80  
Cys Tyr Ile Asn Asp Leu Thr Val Ile Gln Ser Thr Gln Gly Met Tyr
                85                  90                  95      
Lys Tyr Leu Glu Arg Cys Phe Ser Asp Phe Lys Gln Arg Gly Phe Val
            100                 105                 110         
Val Gly Tyr Asp Thr Arg Gly Gln Val Thr Ser Ser Cys Ser Ser Gln
        115                 120                 125             
Arg Leu Ala Lys Leu Thr Ala Ala Val Leu Leu Ala Lys Asp Val Pro
    130                 135                 140                 
Val Tyr Leu Phe Ser Arg Tyr Val Pro Thr Pro Phe Val Pro Tyr Ala
145                 150                 155                 160 
Val Gln Lys Leu Lys Ala Val Ala Gly Val Met Ile Thr Ala Ser His
                165                 170                 175     
Asn Arg Lys Glu Asp Asn Gly Tyr Lys Val Tyr Trp Glu Thr Gly Ala
            180                 185                 190         
Gln Ile Thr Ser Pro His Asp Lys Glu Ile Leu Lys Cys Ile Glu Glu
        195                 200                 205             
Cys Val Glu Pro Trp Asn Gly Ser Trp Asn Asp Asn Leu Val Asp Thr
    210                 215                 220                 
Ser Pro Leu Lys Arg Asp Pro Leu Gln Asp Ile Cys Arg Arg Tyr Met
225                 230                 235                 240 
Glu Asp Leu Lys Lys Ile Cys Phe Tyr Arg Glu Leu Asn Ser Lys Thr
                245                 250                 255     
Thr Leu Lys Phe Val His Thr Ser Phe His Gly Val Gly His Asp Tyr
            260                 265                 270         
Val Gln Leu Ala Phe Lys Val Phe Gly Phe Lys Pro Pro Ile Pro Val
        275                 280                 285             
Pro Glu Gln Lys Asp Pro Asp Pro Asp Phe Ser Thr Val Lys Cys Pro
    290                 295                 300                 
Asn Pro Glu Glu Gly Glu Ser Val Leu Glu Leu Ser Leu Arg Leu Ala
305                 310                 315                 320 
Glu Lys Glu Asn Ala Arg Val Val Leu Ala Thr Asp Pro Asp Ala Asp
                325                 330                 335     
Arg Leu Ala Ala Ala Glu Leu Gln Glu Asn Gly Cys Trp Lys Val Phe
            340                 345                 350         
Thr Gly Asn Glu Leu Ala Ala Leu Phe Gly Trp Trp Met Phe Asp Cys
        355                 360                 365             
Trp Lys Lys Asn Lys Ser Arg Asn Ala Asp Val Lys Asn Val Tyr Met
    370                 375                 380                 
Leu Ala Thr Thr Val Ser Ser Lys Ile Leu Lys Ala Ile Ala Leu Lys
385                 390                 395                 400 
Glu Gly Phe His Phe Glu Glu Thr Leu Pro Gly Phe Lys Trp Ile Gly
                405                 410                 415     
Ser Arg Ile Ile Asp Leu Leu Glu Asn Gly Lys Glu Val Leu Phe Ala
            420                 425                 430         
Phe Glu Glu Ser Ile Gly Phe Leu Cys Gly Thr Ser Val Leu Asp Lys
        435                 440                 445             
Asp Gly Val Ser Ala Ala Val Val Val Ala Glu Met Ala Ser Tyr Leu
    450                 455                 460                 
Glu Thr Met Asn Ile Thr Leu Lys Gln Gln Leu Val Lys Val Tyr Glu
465                 470                 475                 480 
Lys Tyr Gly Tyr His Ile Ser Lys Thr Ser Tyr Phe Leu Cys Tyr Glu
                485                 490                 495     
Pro Pro Thr Ile Lys Ser Ile Phe Glu Arg Leu Arg Asn Phe Asp Ser
            500                 505                 510         
Pro Lys Glu Tyr Pro Lys Phe Cys Gly Thr Phe Ala Ile Leu His Val
        515                 520                 525             
Arg Asp Val Thr Thr Gly Tyr Asp Ser Ser Gln Pro Asn Lys Lys Ser
    530                 535                 540                 
Val Leu Pro Val Ser Lys Asn Ser Gln Met Ile Thr Phe Thr Phe Gln
545                 550                 555                 560 
Asn Gly Cys Val Ala Thr Leu Arg Thr Ser Gly Thr Glu Pro Lys Ile
                565                 570                 575     
Lys Tyr Tyr Ala Glu Met Cys Ala Ser Pro Asp Gln Ser Asp Thr Ala
            580                 585                 590         
Leu Leu Glu Glu Glu Leu Lys Lys Leu Ile Asp Ala Leu Ile Glu Asn
        595                 600                 605             
Phe Leu Gln Pro Ser Lys Asn Gly Leu Ile Trp Arg Ser Val
    610                 615                 620         


<210> 6205
<211> 446
<212> PRT
<213> Homo sapiens

<400> 6205
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile
 1               5                  10                  15      
Gly Thr Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro
            20                  25                  30          
Ala Gly Gly Tyr Val Gly Asp Ser Ala Leu Gln Leu Glu Arg Ile Asn
        35                  40                  45              
Val Tyr Tyr Asn Glu Ser Ser Ser Gln Lys Tyr Val Pro Arg Ala Ala
    50                  55                  60                  
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro
65                  70                  75                  80  
Phe Gly Gln Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Thr Gly
                85                  90                  95      
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu
            100                 105                 110         
Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Cys Glu His Cys Asp
        115                 120                 125             
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly
    130                 135                 140                 
Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Phe Pro
145                 150                 155                 160 
Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser
                165                 170                 175     
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu
            180                 185                 190         
Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr
        195                 200                 205             
Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp
    210                 215                 220                 
Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu
225                 230                 235                 240 
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn
                245                 250                 255     
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro
            260                 265                 270         
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu
        275                 280                 285             
Leu Thr Gln Gln Met Phe Asp Ala Arg Asn Met Met Ala Ala Cys Asp
    290                 295                 300                 
Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Pro
305                 310                 315                 320 
Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys
                325                 330                 335     
Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala
            340                 345                 350         
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Ser Thr Phe Ile
        355                 360                 365             
Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln
    370                 375                 380                 
Phe Ser Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Phe Thr Gly
385                 390                 395                 400 
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn
                405                 410                 415     
Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asn Asp
            420                 425                 430         
Gly Glu Glu Ala Phe Glu Asp Glu Glu Glu Glu Ile Asp Gly
        435                 440                 445     


<210> 6206
<211> 421
<212> PRT
<213> Homo sapiens

<400> 6206
Met Ser Ala Thr Leu Ile Leu Glu Pro Pro Gly Arg Cys Cys Trp Asn
 1               5                  10                  15      
Glu Pro Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Arg Val
            20                  25                  30          
Thr Leu Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Arg Ala
        35                  40                  45              
His Ala Arg Tyr Cys Ala Asp Ala Arg Gly Glu Leu Asp Leu Glu Arg
    50                  55                  60                  
Ala Pro Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu
65                  70                  75                  80  
Leu Trp Ala Leu Glu Pro Glu Lys Pro Phe Trp Arg Phe Leu Lys Arg
                85                  90                  95      
Asp Val Gln Ile Pro Phe Val Val Glu Leu Glu Val Leu Asp Gly His
            100                 105                 110         
Asp Pro Glu Pro Gly Arg Leu Leu Cys Gln Ala Gln His Glu Arg His
        115                 120                 125             
Phe Pro Pro Pro Gly Val Arg Arg Gln Ser Val Arg Ala Gly Arg Val
    130                 135                 140                 
Arg Ala Thr Leu Phe Leu Pro Pro Gly Pro Gly Pro Phe Pro Gly Ile
145                 150                 155                 160 
Ile Asp Ile Phe Gly Ile Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser
                165                 170                 175     
Leu Leu Ala Gly His Gly Phe Ala Thr Leu Asp Leu Gln Ser Tyr Asn
            180                 185                 190         
Phe Glu Asp Leu Pro Asn Asn Met Asp Asn Ile Ser Leu Glu Tyr Phe
        195                 200                 205             
Glu Glu Ala Val Cys Tyr Met Leu Gln His Pro Gln Val Lys Gly Pro
    210                 215                 220                 
Gly Ile Gly Leu Leu Gly Ile Ser Leu Gly Ala Asp Ile Cys Leu Ser
225                 230                 235                 240 
Met Ala Ser Phe Leu Lys Asn Val Ser Ala Thr Val Ser Ile Asn Gly
                245                 250                 255     
Ser Gly Ile Ser Gly Asn Thr Ala Ile Asn Tyr Lys His Ser Ser Ile
            260                 265                 270         
Pro Pro Leu Gly Tyr Asp Leu Arg Arg Ile Lys Val Ala Phe Ser Gly
        275                 280                 285             
Leu Val Asp Ile Val Asp Ile Arg Asn Ala Leu Val Gly Gly Tyr Lys
    290                 295                 300                 
Asn Pro Ser Met Ile Pro Ile Glu Lys Ala Gln Gly Pro Ile Leu Leu
305                 310                 315                 320 
Ile Val Gly Gln Asp Asp His Asn Trp Arg Ser Glu Leu Tyr Ala Gln
                325                 330                 335     
Thr Val Ser Glu Arg Leu Gln Ala His Gly Lys Glu Lys Pro Gln Ile
            340                 345                 350         
Ile Cys Tyr Pro Gly Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro
        355                 360                 365             
Leu Cys Pro Ala Ser Leu His Arg Leu Leu Asn Lys His Val Ile Trp
    370                 375                 380                 
Gly Gly Glu Pro Arg Ala His Ser Lys Ala Gln Glu Asp Ala Trp Lys
385                 390                 395                 400 
Gln Ile Leu Ala Phe Phe Cys Lys His Leu Gly Gly Thr Gln Lys Thr
                405                 410                 415     
Ala Val Pro Lys Leu
            420     


<210> 6207
<211> 1740
<212> PRT
<213> Homo sapiens

<400> 6207
Met Gly Arg Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg
 1               5                  10                  15      
Pro Gln Leu Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln
            20                  25                  30          
Ser Ser Pro Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg
        35                  40                  45              
Tyr Pro Ile Gly Ile Gln Gly Arg Thr Pro Gly Ala Met Ala Gly Met
    50                  55                  60                  
Gln Tyr Pro Gln Gln Gln Asp Ser Gly Asp Ala Thr Trp Lys Glu Thr
65                  70                  75                  80  
Phe Trp Leu Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr
                85                  90                  95      
Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro
            100                 105                 110         
His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg
        115                 120                 125             
Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Thr Arg Ser
    130                 135                 140                 
Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu
145                 150                 155                 160 
Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile
                165                 170                 175     
Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser Ala Ala Ser
            180                 185                 190         
Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln
        195                 200                 205             
Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly
    210                 215                 220                 
Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser
225                 230                 235                 240 
Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro
                245                 250                 255     
Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu
            260                 265                 270         
Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Thr Gln
        275                 280                 285             
Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr Gly Pro Ser
    290                 295                 300                 
Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser
305                 310                 315                 320 
Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln Met Ser
                325                 330                 335     
Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly
            340                 345                 350         
Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser
        355                 360                 365             
Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala
    370                 375                 380                 
Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe
385                 390                 395                 400 
Pro Gly Asn Met Ser Ser Met Pro Pro Ser Ser Pro Gly Met Ser Gln
                405                 410                 415     
Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys
            420                 425                 430         
Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala
        435                 440                 445             
Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met
    450                 455                 460                 
Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu
465                 470                 475                 480 
Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn
                485                 490                 495     
Ser Ser Ala Ala Ser Val Gly Leu Ala Asp Met Met Ser Pro Gly Glu
            500                 505                 510         
Ser Lys Leu Pro Leu Pro Leu Lys Ala Asp Gly Lys Glu Glu Gly Thr
        515                 520                 525             
Pro Gln Pro Glu Ser Lys Ser Lys Lys Ser Ser Ser Ser Thr Thr Thr
    530                 535                 540                 
Gly Glu Lys Ile Thr Lys Val Tyr Glu Leu Gly Asn Glu Pro Glu Arg
545                 550                 555                 560 
Lys Leu Trp Val Asp Arg Tyr Leu Thr Phe Met Glu Glu Arg Gly Ser
                565                 570                 575     
Pro Val Ser Ser Leu Pro Ala Val Gly Lys Lys Pro Leu Asp Leu Phe
            580                 585                 590         
Arg Leu Tyr Val Cys Val Lys Glu Ile Gly Gly Leu Ala Gln Val Asn
        595                 600                 605             
Lys Asn Lys Lys Trp Arg Glu Leu Ala Thr Asn Leu Asn Val Gly Thr
    610                 615                 620                 
Ser Ser Ser Ala Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Tyr Leu
625                 630                 635                 640 
Phe Ala Phe Glu Cys Lys Ile Glu Arg Gly Glu Glu Pro Pro Pro Glu
                645                 650                 655     
Val Phe Ser Thr Gly Asp Thr Lys Lys Gln Pro Lys Leu Gln Pro Pro
            660                 665                 670         
Ser Pro Ala Asn Ser Gly Ser Leu Gln Gly Pro Gln Thr Pro Gln Ser
        675                 680                 685             
Thr Gly Ser Asn Ser Met Ala Glu Val Pro Gly Asp Leu Lys Pro Pro
    690                 695                 700                 
Thr Pro Ala Ser Thr Pro His Gly Gln Met Thr Pro Met Gln Gly Gly
705                 710                 715                 720 
Arg Ser Ser Thr Ile Ser Val His Asp Pro Phe Ser Asp Val Ser Asp
                725                 730                 735     
Ser Ser Phe Pro Lys Arg Asn Ser Met Thr Pro Asn Ala Pro Tyr Gln
            740                 745                 750         
Gln Gly Met Ser Met Pro Asp Val Met Gly Arg Met Pro Tyr Glu Pro
        755                 760                 765             
Asn Lys Asp Pro Phe Gly Gly Met Arg Lys Val Pro Gly Ser Ser Glu
    770                 775                 780                 
Pro Phe Met Thr Gln Gly Gln Met Pro Asn Ser Ser Met Gln Asp Met
785                 790                 795                 800 
Tyr Asn Gln Ser Pro Ser Gly Ala Met Ser Asn Leu Gly Met Gly Gln
                805                 810                 815     
Arg Gln Gln Phe Pro Tyr Gly Ala Ser Tyr Asp Arg Arg His Glu Pro
            820                 825                 830         
Tyr Gly Gln Gln Tyr Pro Gly Gln Gly Pro Pro Ser Gly Gln Pro Pro
        835                 840                 845             
Tyr Gly Gly His Gln Pro Gly Leu Tyr Pro Gln Gln Pro Asn Tyr Lys
    850                 855                 860                 
Arg His Met Asp Gly Met Tyr Gly Pro Pro Ala Lys Arg His Glu Gly
865                 870                 875                 880 
Asp Met Tyr Asn Met Gln Tyr Ser Ser Gln Gln Gln Glu Met Tyr Asn
                885                 890                 895     
Gln Tyr Gly Gly Ser Tyr Ser Gly Pro Asp Arg Arg Pro Ile Gln Gly
            900                 905                 910         
Gln Tyr Pro Tyr Pro Tyr Ser Arg Glu Arg Met Gln Gly Pro Gly Gln
        915                 920                 925             
Ile Gln Thr His Gly Ile Pro Pro Gln Met Met Gly Gly Pro Leu Gln
    930                 935                 940                 
Ser Ser Ser Ser Glu Gly Pro Gln Gln Asn Met Trp Ala Ala Arg Asn
945                 950                 955                 960 
Asp Met Pro Tyr Pro Tyr Gln Asn Arg Gln Gly Pro Gly Gly Pro Thr
                965                 970                 975     
Gln Ala Pro Pro Tyr Pro Gly Met Asn Arg Thr Asp Asp Met Met Val
            980                 985                 990         
Pro Asp Gln Arg Ile Asn His Glu Ser Gln Trp Pro Ser His Val Ser
        995                 1000                1005            
Gln Arg Gln Pro Tyr Met Ser Ser Ser Ala Ser Met Gln Pro Ile Thr
    1010                1015                1020                
Arg Pro Pro Gln Pro Ser Tyr Gln Thr Pro Pro Ser Leu Pro Asn His
1025                1030                1035                1040
Ile Ser Arg Ala Pro Ser Pro Ala Ser Phe Gln Arg Ser Leu Glu Asn
                1045                1050                1055    
Arg Met Ser Pro Ser Lys Ser Pro Phe Leu Pro Ser Met Lys Met Gln
            1060                1065                1070        
Lys Val Met Pro Thr Val Pro Thr Ser Gln Val Thr Gly Pro Pro Pro
        1075                1080                1085            
Gln Pro Pro Pro Ile Arg Arg Glu Ile Thr Phe Pro Pro Gly Ser Val
    1090                1095                1100                
Glu Ala Ser Gln Pro Val Leu Lys Gln Arg Arg Lys Ile Thr Ser Lys
1105                1110                1115                1120
Asp Ile Val Thr Pro Glu Ala Trp Arg Val Met Met Ser Leu Lys Ser
                1125                1130                1135    
Gly Leu Leu Ala Glu Ser Thr Trp Ala Leu Asp Thr Ile Asn Ile Leu
            1140                1145                1150        
Leu Tyr Asp Asp Ser Thr Val Ala Thr Phe Asn Leu Ser Gln Leu Ser
        1155                1160                1165            
Gly Phe Leu Glu Leu Leu Val Glu Tyr Phe Arg Lys Cys Leu Ile Asp
    1170                1175                1180                
Ile Phe Gly Ile Leu Met Glu Tyr Glu Val Gly Asp Pro Ser Gln Lys
1185                1190                1195                1200
Ala Leu Asp His Asn Ala Ala Arg Lys Asp Asp Ser Gln Ser Leu Ala
                1205                1210                1215    
Asn Asp Ser Gly Lys Glu Glu Glu Asp Ala Glu Cys Ile Asp Asp Asp
            1220                1225                1230        
Glu Glu Asp Glu Glu Asp Glu Glu Glu Asp Ser Glu Lys Thr Glu Ser
        1235                1240                1245            
Asp Glu Lys Ser Ser Ile Ala Leu Thr Ala Pro Asp Ala Ala Ala Asp
    1250                1255                1260                
Pro Lys Glu Lys Pro Lys Gln Ala Ser Lys Phe Asp Lys Leu Pro Ile
1265                1270                1275                1280
Lys Ile Val Lys Lys Asn Asn Leu Phe Val Val Asp Arg Ser Asp Lys
                1285                1290                1295    
Leu Gly Arg Val Gln Glu Phe Asn Ser Gly Leu Leu His Trp Gln Leu
            1300                1305                1310        
Gly Gly Gly Asp Thr Thr Glu His Ile Gln Thr His Phe Glu Ser Lys
        1315                1320                1325            
Met Glu Ile Pro Pro Arg Arg Arg Pro Pro Pro Pro Leu Ser Ser Ala
    1330                1335                1340                
Gly Arg Lys Lys Glu Gln Glu Gly Lys Gly Asp Ser Glu Glu Gln Gln
1345                1350                1355                1360
Glu Lys Ser Ile Ile Ala Thr Ile Asp Asp Val Leu Ser Ala Arg Pro
                1365                1370                1375    
Gly Ala Leu Pro Glu Asp Ala Asn Pro Gly Pro Gln Thr Glu Ser Ser
            1380                1385                1390        
Lys Phe Pro Phe Gly Ile Gln Gln Ala Lys Ser His Arg Asn Ile Lys
        1395                1400                1405            
Leu Leu Glu Asp Glu Pro Arg Ser Arg Asp Glu Thr Pro Leu Cys Thr
    1410                1415                1420                
Ile Ala His Trp Gln Asp Ser Leu Ala Lys Arg Cys Ile Cys Val Ser
1425                1430                1435                1440
Asn Ile Val Arg Ser Leu Ser Phe Val Pro Gly Asn Asp Ala Glu Met
                1445                1450                1455    
Ser Lys His Pro Gly Leu Val Leu Ile Leu Gly Lys Leu Ile Leu Leu
            1460                1465                1470        
His His Glu His Pro Glu Arg Lys Arg Ala Pro Gln Thr Tyr Glu Lys
        1475                1480                1485            
Glu Glu Asp Glu Asp Lys Gly Val Ala Cys Ser Lys Asp Glu Trp Trp
    1490                1495                1500                
Trp Asp Cys Leu Glu Val Leu Arg Asp Asn Thr Leu Val Thr Leu Ala
1505                1510                1515                1520
Asn Ile Ser Gly Gln Leu Asp Leu Ser Ala Tyr Thr Glu Ser Ile Cys
                1525                1530                1535    
Leu Pro Ile Leu Asp Gly Leu Leu His Trp Met Val Cys Pro Ser Ala
            1540                1545                1550        
Glu Ala Gln Asp Pro Phe Pro Thr Val Gly Pro Asn Ser Val Leu Ser
        1555                1560                1565            
Pro Gln Arg Leu Val Leu Glu Thr Leu Cys Lys Leu Ser Ile Gln Asp
    1570                1575                1580                
Asn Asn Val Asp Leu Ile Leu Ala Thr Pro Pro Phe Ser Arg Gln Glu
1585                1590                1595                1600
Lys Phe Tyr Ala Thr Leu Val Arg Tyr Val Gly Asp Arg Lys Asn Pro
                1605                1610                1615    
Val Cys Arg Glu Met Ser Met Ala Leu Leu Ser Asn Leu Ala Gln Gly
            1620                1625                1630        
Asp Ala Leu Ala Ala Arg Ala Ile Ala Val Gln Lys Gly Ser Ile Gly
        1635                1640                1645            
Asn Leu Ile Ser Phe Leu Glu Asp Gly Val Thr Met Ala Gln Tyr Gln
    1650                1655                1660                
Gln Ser Gln His Asn Leu Met His Met Gln Pro Pro Pro Leu Glu Pro
1665                1670                1675                1680
Pro Ser Val Asp Met Met Cys Arg Ala Ala Lys Ala Leu Leu Ala Met
                1685                1690                1695    
Ala Arg Val Asp Glu Asn Arg Ser Glu Phe Leu Leu His Glu Gly Arg
            1700                1705                1710        
Leu Leu Asp Ile Ser Ile Ser Ala Val Leu Asn Ser Leu Val Ala Ser
        1715                1720                1725            
Val Ile Cys Asp Val Leu Phe Gln Ile Gly Gln Leu
    1730                1735                1740


<210> 6208
<211> 196
<212> PRT
<213> Homo sapiens

<400> 6208
Met Glu Lys Arg Met Thr Ile Leu Tyr Gly Glu Cys His Asn Gln Gly
 1               5                  10                  15      
Leu Gly Phe Ala Asn Ala Ala Thr Asp Ala Arg Ser Ser Val Arg Ser
            20                  25                  30          
Ala Met Val Asn Pro Thr Val Phe Asp Ile Ala Val Asp Gly Lys Pro
        35                  40                  45              
Leu Gly Arg Val Ser Phe Glu Pro Phe Ala Asp Lys Val Pro Lys Ala
    50                  55                  60                  
Ala Glu Asn Phe Arg Ala Leu Ser Asn Val Glu Lys Gly Phe Gly Tyr
65                  70                  75                  80  
Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly
                85                  90                  95      
Gly Asp Phe Thr Cys His Asn Gly Thr Gly Gly Lys Tyr Thr Cys Gly
            100                 105                 110         
Glu Lys Phe Asp Asp Glu Ser Phe Val Leu Lys His Thr His Pro Gly
        115                 120                 125             
Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Cys
    130                 135                 140                 
Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Asn Pro Val Val
145                 150                 155                 160 
Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Gly His
                165                 170                 175     
Phe Gly Ser Glu Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp
            180                 185                 190         
Cys Gly Gln Leu
        195     


<210> 6209
<211> 936
<212> PRT
<213> Homo sapiens

<400> 6209
Met Leu Arg Pro Glu Ile Ser Ser Thr Ser Pro Ser Ala Pro Ala Val
 1               5                  10                  15      
Ser Pro Ser Ser Gly Glu Thr Arg Ser Pro Gln Gly Pro Arg Tyr Asn
            20                  25                  30          
Phe Gly Leu Gln Glu Thr Pro Gln Ser Arg Pro Ser Val Gln Val Val
        35                  40                  45              
Ser Ala Ser Thr Cys Pro Gly Thr Ser Gly Ala Ala Gly Asp Arg Ser
    50                  55                  60                  
Ser Ser Ser Ser Ser Leu Pro Cys Pro Ala Pro Asn Ser Arg Pro Ala
65                  70                  75                  80  
Gln Gly Ser Tyr Phe Gly Asn Lys Arg Ala Tyr Ala Glu Asn Thr Val
                85                  90                  95      
Ala Ser Asn Phe Thr Phe Gly Ala Ser Ser Ser Ser Ala Arg Asp Thr
            100                 105                 110         
Asn Tyr Pro Gln Thr Leu Lys Thr Pro Leu Ser Thr Gly Asn Pro Gln
        115                 120                 125             
Arg Ser Gly Tyr Lys Ser Trp Thr Pro Gln Val Gly Tyr Ser Ala Ser
    130                 135                 140                 
Ser Ser Ser Ala Ile Ser Ala His Ser Pro Ser Val Ile Val Ala Val
145                 150                 155                 160 
Val Glu Gly Arg Gly Leu Ala Arg Gly Glu Ile Gly Met Ala Ser Ile
                165                 170                 175     
Asp Leu Lys Asn Pro Gln Ile Ile Leu Ser Gln Phe Ala Asp Asn Thr
            180                 185                 190         
Thr Tyr Ala Lys Val Ile Thr Lys Leu Lys Ile Leu Ser Pro Leu Glu
        195                 200                 205             
Ile Ile Met Ser Asn Thr Ala Cys Ala Val Gly Asn Ser Thr Lys Leu
    210                 215                 220                 
Phe Thr Leu Ile Thr Glu Asn Phe Lys Asn Val Asn Phe Thr Thr Ile
225                 230                 235                 240 
Gln Arg Lys Tyr Phe Asn Glu Thr Lys Gly Leu Glu Tyr Ile Glu Gln
                245                 250                 255     
Leu Cys Ile Ala Glu Phe Ser Thr Val Leu Met Glu Val Gln Ser Lys
            260                 265                 270         
Tyr Tyr Cys Leu Ala Ala Val Ala Ala Leu Leu Lys Tyr Val Glu Phe
        275                 280                 285             
Ile Gln Asn Ser Val Tyr Ala Pro Lys Ser Leu Lys Ile Cys Phe Gln
    290                 295                 300                 
Gly Ser Glu Gln Thr Ala Met Ile Asp Ser Ser Ser Ala Gln Asn Leu
305                 310                 315                 320 
Glu Leu Leu Ile Asn Asn Gln Asp Tyr Arg Asn Asn His Thr Leu Phe
                325                 330                 335     
Gly Val Leu Asn Tyr Thr Lys Thr Pro Gly Gly Ser Arg Arg Leu Arg
            340                 345                 350         
Ser Asn Ile Leu Glu Pro Leu Val Asp Ile Glu Thr Ile Asn Met Arg
        355                 360                 365             
Leu Asp Cys Val Gln Glu Leu Leu Gln Asp Glu Glu Leu Phe Phe Gly
    370                 375                 380                 
Leu Gln Ser Val Ile Ser Arg Phe Leu Asp Thr Glu Gln Leu Leu Ser
385                 390                 395                 400 
Val Leu Val Gln Ile Pro Lys Gln Asp Thr Val Asn Ala Ala Glu Ser
                405                 410                 415     
Lys Ile Thr Asn Leu Ile Tyr Leu Lys His Thr Leu Glu Leu Val Asp
            420                 425                 430         
Pro Leu Lys Ile Ala Met Lys Asn Cys Asn Thr Pro Leu Leu Arg Ala
        435                 440                 445             
Tyr Tyr Gly Ser Leu Glu Asp Lys Arg Phe Gly Ile Ile Leu Glu Lys
    450                 455                 460                 
Ile Lys Thr Val Ile Asn Asp Asp Ala Arg Tyr Met Lys Gly Cys Leu
465                 470                 475                 480 
Asn Met Arg Thr Gln Lys Cys Tyr Ala Val Arg Ser Asn Ile Asn Glu
                485                 490                 495     
Phe Leu Asp Ile Ala Arg Arg Thr Tyr Thr Glu Ile Val Asp Asp Ile
            500                 505                 510         
Ala Gly Met Ile Ser Gln Leu Gly Glu Lys Tyr Ser Leu Pro Leu Arg
        515                 520                 525             
Thr Ser Phe Ser Ser Ala Arg Gly Phe Phe Ile Gln Met Thr Thr Asp
    530                 535                 540                 
Cys Ile Ala Leu Pro Ser Asp Gln Leu Pro Ser Glu Phe Ile Lys Ile
545                 550                 555                 560 
Ser Lys Val Lys Asn Ser Tyr Ser Phe Thr Ser Ala Asp Leu Ile Lys
                565                 570                 575     
Met Asn Glu Arg Cys Gln Glu Ser Leu Arg Glu Ile Tyr His Met Thr
            580                 585                 590         
Tyr Met Ile Val Cys Lys Leu Leu Ser Glu Ile Tyr Glu His Ile His
        595                 600                 605             
Cys Leu Tyr Lys Leu Ser Asp Thr Val Ser Met Leu Asp Met Leu Leu
    610                 615                 620                 
Ser Phe Ala His Ala Cys Thr Leu Ser Asp Tyr Val Arg Pro Glu Phe
625                 630                 635                 640 
Thr Asp Thr Leu Ala Ile Lys Gln Gly Trp His Pro Ile Leu Glu Lys
                645                 650                 655     
Ile Ser Ala Glu Lys Pro Ile Ala Asn Asn Thr Tyr Val Thr Glu Gly
            660                 665                 670         
Ser Asn Phe Leu Ile Ile Thr Gly Pro Asn Met Ser Gly Lys Ser Thr
        675                 680                 685             
Tyr Leu Lys Gln Ile Ala Leu Cys Gln Ile Met Ala Gln Ile Gly Ser
    690                 695                 700                 
Tyr Val Pro Ala Glu Tyr Ser Ser Phe Arg Ile Ala Lys Gln Ile Phe
705                 710                 715                 720 
Thr Arg Ile Ser Thr Asp Asp Asp Ile Glu Thr Asn Ser Ser Thr Phe
                725                 730                 735     
Met Lys Glu Met Lys Glu Ile Ala Tyr Ile Leu His Asn Ala Asn Asp
            740                 745                 750         
Lys Ser Leu Ile Leu Ile Asp Glu Leu Gly Arg Gly Thr Asn Thr Glu
        755                 760                 765             
Glu Gly Ile Gly Ile Cys Tyr Ala Val Cys Glu Tyr Leu Leu Ser Leu
    770                 775                 780                 
Lys Ala Phe Thr Leu Phe Ala Thr His Phe Leu Glu Leu Cys His Ile
785                 790                 795                 800 
Asp Ala Leu Tyr Pro Asn Val Glu Asn Met His Phe Glu Val Gln His
                805                 810                 815     
Val Lys Asn Thr Ser Arg Asn Lys Glu Ala Ile Leu Tyr Thr Tyr Lys
            820                 825                 830         
Leu Ser Lys Gly Leu Thr Glu Glu Lys Asn Tyr Gly Leu Lys Ala Ala
        835                 840                 845             
Glu Val Ser Ser Leu Pro Pro Ser Ile Val Leu Asp Ala Lys Glu Ile
    850                 855                 860                 
Thr Thr Gln Ile Thr Arg Gln Ile Leu Gln Asn Gln Arg Ser Thr Pro
865                 870                 875                 880 
Glu Met Glu Arg Gln Arg Ala Val Tyr His Leu Ala Thr Arg Leu Val
                885                 890                 895     
Gln Thr Ala Arg Asn Ser Gln Leu Asp Pro Asp Ser Leu Arg Ile Tyr
            900                 905                 910         
Leu Ser Asn Leu Lys Lys Lys Tyr Lys Glu Asp Phe Pro Arg Thr Glu
        915                 920                 925             
Gln Val Pro Glu Lys Thr Glu Glu
    930                 935     


<210> 6210
<211> 707
<212> PRT
<213> Homo sapiens

<400> 6210
Met Ser Ser Gly Ser Ser Leu Gly Ser Leu Ala Ser Ser Arg Gly Ser
 1               5                  10                  15      
Leu Asn Thr Ser Ser Arg Gly Ser Leu Asn Ser Leu Ser Ser Thr Glu
            20                  25                  30          
Leu Tyr Tyr Ser Ser Gln Ser Asp Gln Ile Asp Val Asp Tyr Gln Tyr
        35                  40                  45              
Lys Leu Asp Phe Leu Leu Gln Glu Lys Ser Gly Tyr Ile Pro Ser Gly
    50                  55                  60                  
Pro Ile Thr Thr Ile His Glu Asn Glu Val Val Lys Ser Pro Ser Gln
65                  70                  75                  80  
Pro Gly Gln Ser Gly Leu Cys Gly Val Ala Ala Ala Ala Thr Gly His
                85                  90                  95      
Thr Pro Pro Leu Ala Glu Ala Pro Lys Ser Val Ala Ser Leu Ser Ser
            100                 105                 110         
Arg Ser Ser Leu Ser Ser Leu Ser Pro Pro Gly Ser Pro Leu Val Leu
        115                 120                 125             
Glu Gly Thr Phe Pro Met Ser Ser Ser His Asp Ala Ser Leu His Gln
    130                 135                 140                 
Phe Thr Ala Asp Phe Glu Asp Tyr Val Glu Lys Ser Leu Pro Lys Arg
145                 150                 155                 160 
Arg Val Ile His Leu Leu Gly Glu Lys Thr Thr Cys Val Ser Ala Ala
                165                 170                 175     
Val Ser Asp Glu Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Phe
            180                 185                 190         
Val Lys Gln Pro Ser Glu Met Glu Asp Val Thr Tyr Ser Glu Glu Asp
        195                 200                 205             
Val Ala Ile Val Glu Thr Ala Gln Val Gln Ile Gly Leu Arg Tyr Asn
    210                 215                 220                 
Ala Lys Ser Ser Ser Phe Met Val Ile Ile Ala Gln Leu Arg Asn Leu
225                 230                 235                 240 
His Ala Phe Leu Ile Pro His Thr Ser Lys Val Tyr Phe Arg Val Ala
                245                 250                 255     
Val Leu Pro Ser Ser Thr Asp Val Ser Cys Leu Phe Arg Thr Lys Val
            260                 265                 270         
His Pro Pro Thr Glu Ser Ile Leu Phe Asn Asp Val Phe Arg Val Ala
        275                 280                 285             
Ile Ser Gln Thr Ala Leu Gln Gln Lys Thr Leu Arg Val Asp Leu Cys
    290                 295                 300                 
Ser Val Ser Lys His Arg Arg Glu Glu Cys Leu Ala Gly Thr Gln Ile
305                 310                 315                 320 
Ser Leu Ala Asp Leu Pro Phe Ser Ser Glu Phe Phe Thr Leu Trp Tyr
                325                 330                 335     
Asn Leu Leu Pro Ser Lys Gln Met Pro Cys Lys Lys Asn Glu Glu Asn
            340                 345                 350         
Glu Asp Ser Val Phe Gln Pro Asn Gln Pro Leu Val Asp Ser Ile Asp
        355                 360                 365             
Leu Asp Ala Val Ser Ala Leu Leu Ala Arg Thr Ser Ala Glu Leu Leu
    370                 375                 380                 
Ala Val Glu Gln Glu Leu Ala Gln Glu Glu Glu Glu Glu Ser Gly Gln
385                 390                 395                 400 
Glu Glu Pro Arg Gly Pro Asp Gly Asp Trp Leu Thr Met Leu Arg Glu
                405                 410                 415     
Ala Ser His Glu Ile Val Ala Glu Lys Glu Ala Glu Val Lys Leu Pro
            420                 425                 430         
Glu Asp Ser Ser Cys Thr Glu Asp Leu Ser Ser Cys Thr Ser Val Pro
        435                 440                 445             
Glu Met Asn Glu Asp Gly Asn Arg Lys Glu Ser Asn Cys Ala Lys Asp
    450                 455                 460                 
Leu Arg Ser Gln Pro Pro Thr Arg Ile Pro Thr Leu Val Asp Lys Glu
465                 470                 475                 480 
Thr Asn Thr Asp Glu Ala Ala Asn Asp Asn Met Ala Val Arg Pro Lys
                485                 490                 495     
Glu Arg Ser Ser Leu Ser Ser Arg Gln His Pro Phe Val Arg Ser Ser
            500                 505                 510         
Val Ile Val Arg Ser Gln Thr Phe Ser Pro Gly Glu Arg Asn Gln Tyr
        515                 520                 525             
Ile Cys Arg Leu Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu Ala Lys
    530                 535                 540                 
Lys Ser Leu Phe Val Arg Asn Ser Thr Glu Arg Arg Ser Leu Arg Val
545                 550                 555                 560 
Lys Arg Thr Val Cys Gln Ser Val Leu Arg Arg Thr Thr Gln Glu Cys
                565                 570                 575     
Pro Val Arg Thr Ser Leu Asp Leu Glu Leu Asp Leu Gln Ala Ser Leu
            580                 585                 590         
Thr Arg Gln Ser Arg Leu Asn Asp Glu Leu Gln Ala Leu Arg Asp Leu
        595                 600                 605             
Arg Gln Lys Leu Glu Glu Leu Lys Ala Gln Gly Glu Thr Asp Leu Pro
    610                 615                 620                 
Pro Gly Val Leu Glu Asp Glu Arg Phe Gln Arg Leu Leu Lys Gln Ala
625                 630                 635                 640 
Glu Lys Gln Ala Glu Gln Ser Lys Glu Glu Gln Lys Gln Gly Leu Asn
                645                 650                 655     
Ala Glu Lys Leu Met Arg Gln Val Ser Lys Asp Val Cys Arg Leu Arg
            660                 665                 670         
Glu Gln Ser Gln Lys Val Pro Arg Gln Val Gln Ser Phe Arg Glu Lys
        675                 680                 685             
Ile Ala Tyr Phe Thr Arg Ala Lys Ile Ser Ile Pro Ser Leu Pro Ala
    690                 695                 700                 
Asp Asp Val
705         


<210> 6211
<211> 489
<212> PRT
<213> Homo sapiens

<400> 6211
Met Asp Asp Asp Leu Met Leu Ala Leu Arg Leu Gln Glu Glu Trp Asn
 1               5                  10                  15      
Leu Gln Glu Ala Glu Arg Asp His Ala Gln Glu Ser Leu Ser Leu Val
            20                  25                  30          
Asp Ala Ser Trp Glu Leu Val Asp Pro Thr Pro Asp Leu Gln Ala Leu
        35                  40                  45              
Phe Val Gln Phe Asn Asp Gln Phe Phe Trp Gly Gln Leu Glu Ala Val
    50                  55                  60                  
Glu Val Lys Trp Ser Val Arg Met Thr Leu Cys Ala Gly Ile Cys Ser
65                  70                  75                  80  
Tyr Glu Gly Lys Gly Gly Met Cys Ser Ile Arg Leu Ser Glu Pro Leu
                85                  90                  95      
Leu Lys Leu Arg Pro Arg Lys Asp Leu Val Glu Thr Leu Leu His Glu
            100                 105                 110         
Met Ile His Ala Tyr Leu Phe Val Thr Asn Asn Asp Lys Asp Arg Glu
        115                 120                 125             
Gly His Gly Pro Glu Phe Cys Lys His Met His Arg Ile Asn Ser Leu
    130                 135                 140                 
Thr Gly Ala Asn Ile Thr Val Tyr His Thr Phe His Asp Glu Val Asp
145                 150                 155                 160 
Glu Tyr Arg Arg His Trp Trp Arg Cys Asn Gly Pro Cys Gln His Arg
                165                 170                 175     
Pro Pro Tyr Tyr Gly Tyr Val Lys Arg Ala Thr Asn Arg Glu Pro Ser
            180                 185                 190         
Ala His Asp Tyr Trp Trp Ala Glu His Gln Lys Thr Cys Gly Gly Thr
        195                 200                 205             
Tyr Ile Lys Ile Lys Glu Pro Glu Asn Tyr Ser Lys Lys Gly Lys Gly
    210                 215                 220                 
Lys Ala Lys Leu Gly Lys Glu Pro Val Leu Ala Ala Glu Asn Lys Asp
225                 230                 235                 240 
Lys Pro Asn Arg Gly Glu Ala Gln Leu Val Ile Pro Phe Ser Gly Lys
                245                 250                 255     
Gly Tyr Val Leu Gly Glu Thr Ser Asn Leu Pro Ser Pro Gly Lys Leu
            260                 265                 270         
Ile Thr Ser His Ala Ile Asn Lys Thr Gln Asp Leu Leu Asn Gln Asn
        275                 280                 285             
His Ser Ala Asn Ala Val Arg Leu Asn Ser Lys Ile Lys Val Lys Phe
    290                 295                 300                 
Glu Gln Asn Gly Ser Ser Lys Asn Ser His Leu Val Ser Pro Ala Val
305                 310                 315                 320 
Ser Asn Ser His Gln Asn Val Leu Ser Asn Tyr Phe Pro Arg Val Ser
                325                 330                 335     
Phe Ala Asn Gln Lys Ala Phe Arg Gly Val Asn Gly Ser Pro Arg Ile
            340                 345                 350         
Ser Val Thr Val Gly Asn Ile Pro Lys Asn Ser Val Ser Ser Ser Ser
        355                 360                 365             
Gln Arg Arg Val Ser Ser Ser Lys Ile Ser Leu Arg Asn Ser Ser Lys
    370                 375                 380                 
Val Thr Glu Ser Ala Ser Val Met Pro Ser Gln Asp Val Ser Gly Ser
385                 390                 395                 400 
Glu Asp Thr Phe Pro Asn Lys Arg Pro Arg Leu Glu Asp Lys Thr Val
                405                 410                 415     
Phe Asp Asn Phe Phe Ile Lys Lys Glu Gln Ile Lys Ser Ser Gly Asn
            420                 425                 430         
Asp Pro Lys Tyr Ser Thr Thr Thr Ala Gln Asn Ser Ser Ser Ser Ser
        435                 440                 445             
Ser Gln Ser Lys Met Val Asn Cys Pro Val Cys Gln Asn Glu Val Leu
    450                 455                 460                 
Glu Ser Gln Ile Asn Glu His Leu Asp Trp Cys Leu Glu Gly Asp Ser
465                 470                 475                 480 
Ile Lys Val Lys Ser Glu Glu Ser Leu
                485                 


<210> 6212
<211> 1316
<212> PRT
<213> Homo sapiens

<400> 6212
Met Asp Ser Gln Glu Leu Lys Thr Leu Ile Asn Tyr Tyr Cys Gln Glu
 1               5                  10                  15      
Arg Tyr Phe His His Val Leu Leu Val Ala Ser Glu Gly Ile Lys Arg
            20                  25                  30          
Tyr Gly Ser Asp Pro Val Phe Arg Phe Tyr His Ala Tyr Gly Thr Leu
        35                  40                  45              
Met Glu Gly Lys Thr Gln Glu Ala Leu Arg Glu Phe Glu Ala Ile Lys
    50                  55                  60                  
Asn Lys Gln Asp Val Ser Leu Cys Ser Leu Leu Ala Leu Ile Tyr Ala
65                  70                  75                  80  
His Lys Met Ser Pro Asn Pro Asp Arg Glu Ala Ile Leu Glu Ser Asp
                85                  90                  95      
Ala Arg Val Lys Glu Gln Arg Lys Gly Ala Gly Glu Lys Ala Leu Tyr
            100                 105                 110         
His Ala Gly Leu Phe Leu Trp His Ile Gly Arg His Asp Lys Ala Arg
        115                 120                 125             
Glu Tyr Ile Asp Arg Met Ile Lys Ile Ser Asp Gly Ser Lys Gln Gly
    130                 135                 140                 
His Val Leu Lys Ala Trp Leu Asp Ile Thr Arg Gly Lys Glu Pro Tyr
145                 150                 155                 160 
Thr Lys Lys Ala Leu Lys Tyr Phe Glu Glu Gly Leu Gln Asp Gly Asn
                165                 170                 175     
Asp Thr Phe Ala Leu Leu Gly Lys Ala Gln Cys Leu Glu Met Arg Gln
            180                 185                 190         
Asn Tyr Ser Gly Ala Leu Glu Thr Met Asn Gln Ile Ile Val Asn Phe
        195                 200                 205             
Pro Ser Phe Leu Pro Ala Phe Val Lys Lys Met Lys Leu Gln Leu Ala
    210                 215                 220                 
Leu Gln Asp Trp Asp Gln Thr Val Glu Thr Ala Gln Arg Leu Leu Leu
225                 230                 235                 240 
Gln Asp Ser Gln Asn Val Glu Ala Leu Arg Met Gln Ala Leu Tyr Tyr
                245                 250                 255     
Val Cys Arg Glu Gly Asp Ile Glu Lys Ala Ser Thr Lys Leu Glu Asn
            260                 265                 270         
Leu Gly Asn Ala Leu Asp Ala Met Glu Pro Gln Asn Ala Gln Leu Phe
        275                 280                 285             
Tyr Asn Ile Thr Leu Ala Phe Ser Arg Thr Cys Gly Arg Ser Gln Leu
    290                 295                 300                 
Ile Leu Gln Lys Ile Gln Thr Leu Leu Glu Arg Ala Phe Ser Leu Asn
305                 310                 315                 320 
Pro Gln Gln Ser Glu Phe Ala Thr Glu Leu Gly Tyr Gln Met Ile Leu
                325                 330                 335     
Gln Gly Arg Val Lys Glu Ala Leu Lys Trp Tyr Lys Thr Ala Met Thr
            340                 345                 350         
Leu Asp Glu Thr Ser Val Ser Ala Leu Val Gly Phe Ile Gln Cys Gln
        355                 360                 365             
Leu Ile Glu Gly Gln Leu Gln Asp Ala Asp Gln Gln Leu Glu Phe Leu
    370                 375                 380                 
Asn Glu Ile Gln Gln Ser Ile Gly Lys Ser Ala Glu Leu Ile Tyr Leu
385                 390                 395                 400 
His Ala Val Leu Ala Met Lys Lys Asn Lys Arg Gln Glu Glu Val Ile
                405                 410                 415     
Asn Leu Leu Asn Asp Val Leu Asp Thr His Phe Ser Gln Leu Glu Gly
            420                 425                 430         
Leu Pro Leu Gly Ile Gln Tyr Phe Glu Lys Leu Asn Pro Asp Phe Leu
        435                 440                 445             
Leu Glu Ile Val Met Glu Tyr Leu Ser Phe Cys Pro Met Gln Pro Ala
    450                 455                 460                 
Ser Pro Gly Gln Pro Leu Cys Pro Leu Leu Arg Arg Cys Ile Ser Val
465                 470                 475                 480 
Leu Glu Thr Val Val Arg Thr Val Pro Gly Leu Leu Gln Thr Val Phe
                485                 490                 495     
Leu Ile Ala Lys Val Lys Tyr Leu Ser Gly Asp Ile Glu Ala Ala Phe
            500                 505                 510         
Asn Asn Leu Gln His Cys Leu Glu His Asn Pro Ser Tyr Ala Asp Ala
        515                 520                 525             
His Leu Leu Leu Ala Gln Val Tyr Leu Ser Gln Glu Lys Val Lys Leu
    530                 535                 540                 
Cys Ser Gln Ser Leu Glu Leu Cys Leu Ser Tyr Asp Phe Lys Val Arg
545                 550                 555                 560 
Asp Tyr Pro Leu Tyr His Leu Ile Lys Ala Gln Ser Gln Lys Lys Met
                565                 570                 575     
Gly Glu Ile Ala Asp Ala Ile Lys Thr Leu His Met Ala Met Ser Leu
            580                 585                 590         
Pro Gly Met Lys Arg Ile Gly Ala Ser Thr Lys Ser Lys Asp Arg Lys
        595                 600                 605             
Thr Glu Val Asp Thr Ser His Arg Leu Ser Ile Phe Leu Glu Leu Ile
    610                 615                 620                 
Asp Val His Arg Leu Asn Gly Glu Gln His Glu Ala Thr Lys Val Leu
625                 630                 635                 640 
Gln Asp Ala Ile His Glu Phe Ser Gly Thr Ser Glu Glu Val Arg Val
                645                 650                 655     
Thr Ile Ala Asn Ala Asp Leu Ala Leu Ala Gln Gly Asp Ile Glu Arg
            660                 665                 670         
Ala Leu Ser Ile Leu Gln Asn Val Thr Ala Glu Gln Pro Tyr Phe Ile
        675                 680                 685             
Glu Ala Arg Glu Lys Met Ala Asp Ile Tyr Leu Lys His Arg Lys Asp
    690                 695                 700                 
Lys Met Leu Tyr Ile Thr Cys Phe Arg Glu Ile Ala Glu Arg Met Ala
705                 710                 715                 720 
Asn Pro Arg Ser Phe Leu Leu Leu Gly Asp Ala Tyr Met Asn Ile Leu
                725                 730                 735     
Glu Pro Glu Glu Ala Ile Val Ala Tyr Glu Gln Ala Leu Asn Gln Asn
            740                 745                 750         
Pro Lys Asp Gly Thr Leu Ala Ser Lys Met Gly Lys Ala Leu Ile Lys
        755                 760                 765             
Thr His Asn Tyr Ser Met Ala Ile Thr Tyr Tyr Glu Ala Ala Leu Lys
    770                 775                 780                 
Thr Gly Gln Lys Asn Tyr Leu Cys Tyr Asp Leu Ala Glu Leu Leu Leu
785                 790                 795                 800 
Lys Leu Lys Trp Tyr Asp Lys Ala Glu Lys Val Leu Gln His Ala Leu
                805                 810                 815     
Ala His Glu Pro Val Asn Glu Leu Ser Ala Leu Met Glu Asp Gly Arg
            820                 825                 830         
Cys Gln Val Leu Leu Ala Lys Val Tyr Ser Lys Met Glu Lys Leu Gly
        835                 840                 845             
Asp Ala Ile Thr Ala Leu Gln Gln Ala Arg Glu Leu Gln Ala Arg Val
    850                 855                 860                 
Leu Lys Arg Val Gln Met Glu Gln Pro Asp Ala Val Pro Ala Gln Lys
865                 870                 875                 880 
His Leu Ala Ala Glu Ile Cys Ala Glu Ile Ala Lys His Ser Val Ala
                885                 890                 895     
Gln Arg Asp Tyr Glu Lys Ala Ile Lys Phe Tyr Arg Glu Ala Leu Val
            900                 905                 910         
His Cys Glu Thr Asp Asn Lys Ile Met Leu Glu Leu Ala Arg Leu Tyr
        915                 920                 925             
Leu Ala Gln Asp Asp Pro Asp Ser Cys Leu Arg Gln Cys Ala Leu Leu
    930                 935                 940                 
Leu Gln Ser Asp Gln Asp Asn Glu Ala Ala Thr Met Met Met Ala Asp
945                 950                 955                 960 
Leu Met Phe Arg Lys Gln Asp Tyr Glu Gln Ala Val Phe His Leu Gln
                965                 970                 975     
Gln Leu Leu Glu Arg Lys Pro Asp Asn Tyr Met Thr Leu Ser Arg Leu
            980                 985                 990         
Ile Asp Leu Leu Arg Arg Cys Gly Lys Leu Glu Asp Val Pro Arg Phe
        995                 1000                1005            
Phe Ser Met Ala Glu Lys Arg Asn Ser Arg Ala Lys Leu Glu Pro Gly
    1010                1015                1020                
Phe Gln Tyr Cys Lys Gly Leu Tyr Leu Trp Tyr Thr Gly Glu Pro Asn
1025                1030                1035                1040
Asp Ala Leu Arg His Phe Asn Lys Ala Arg Lys Asp Arg Asp Trp Gly
                1045                1050                1055    
Gln Asn Ala Leu Tyr Asn Met Ile Glu Ile Cys Leu Asn Pro Asp Asn
            1060                1065                1070        
Glu Thr Val Gly Gly Glu Val Phe Glu Asn Leu Asp Gly Asp Leu Gly
        1075                1080                1085            
Asn Ser Thr Glu Lys Gln Glu Ser Val Gln Leu Ala Val Arg Thr Ala
    1090                1095                1100                
Glu Lys Leu Leu Lys Glu Leu Lys Pro Gln Thr Val Gln Gly His Val
1105                1110                1115                1120
Gln Leu Arg Ile Met Glu Asn Tyr Cys Leu Met Ala Thr Lys Gln Lys
                1125                1130                1135    
Ser Asn Val Glu Gln Ala Leu Asn Thr Phe Thr Glu Ile Ala Ala Ser
            1140                1145                1150        
Glu Lys Glu His Ile Pro Ala Leu Leu Gly Met Ala Thr Ala Tyr Met
        1155                1160                1165            
Ile Leu Lys Gln Thr Pro Arg Ala Arg Asn Gln Leu Lys Arg Ile Ala
    1170                1175                1180                
Lys Met Asn Trp Asn Ala Ile Asp Ala Glu Glu Phe Glu Lys Ser Trp
1185                1190                1195                1200
Leu Leu Leu Ala Asp Ile Tyr Ile Gln Ser Ala Lys Tyr Asp Met Ala
                1205                1210                1215    
Glu Asp Leu Leu Lys Arg Cys Leu Arg His Asn Arg Ser Cys Cys Lys
            1220                1225                1230        
Ala Tyr Glu Tyr Met Gly Tyr Ile Met Glu Lys Glu Gln Ala Tyr Thr
        1235                1240                1245            
Asp Ala Ala Leu Asn Tyr Glu Met Ala Trp Lys Tyr Ser Asn Arg Thr
    1250                1255                1260                
Asn Pro Ala Val Gly Tyr Lys Leu Ala Phe Asn Tyr Leu Lys Ala Lys
1265                1270                1275                1280
Arg Tyr Val Asp Ser Ile Asp Ile Cys His Gln Val Leu Glu Ala His
                1285                1290                1295    
Pro Thr Tyr Pro Lys Ile Arg Lys Asp Ile Leu Asp Lys Ala Arg Ala
            1300                1305                1310        
Ser Leu Arg Pro
        1315    


<210> 6213
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 6213
Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln
 1               5                  10                  15      
Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp
            20                  25                  30          
Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu
        35                  40                  45              
Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser
    50                  55                  60                  
Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg
65                  70                  75                  80  
Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro
                85                  90                  95      
Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln
            100                 105                 110         
Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr
        115                 120                 125             
Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg
    130                 135                 140                 
Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His
145                 150                 155                 160 
Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val
                165                 170                 175     
Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu
            180                 185                 190         
Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys
        195                 200                 205             
Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr
    210                 215                 220                 
Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys
225                 230                 235                 240 
Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val
                245                 250                 255     
Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys
            260                 265                 270         
Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu
        275                 280                 285             
Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu
    290                 295                 300                 
Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile
305                 310                 315                 320 
Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu
                325                 330                 335     
Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu
            340                 345                 350         
Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val
        355                 360                 365             
Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His
    370                 375                 380                 
Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro
385                 390                 395                 400 
Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp
                405                 410                 415     
Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro
            420                 425                 430         
Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr
        435                 440                 445             
Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His
    450                 455                 460                 
Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe
465                 470                 475                 480 
Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His
                485                 490                 495     
Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn
            500                 505                 510         
Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu
        515                 520                 525             
Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu
    530                 535                 540                 
Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu
545                 550                 555                 560 
Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys
                565                 570                 575     
Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr
            580                 585                 590         
Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser
        595                 600                 605             
Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro
    610                 615                 620                 
Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn
625                 630                 635                 640 
Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn
                645                 650                 655     
Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser
            660                 665                 670         
Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe
        675                 680                 685             
Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His
    690                 695                 700                 
Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met
705                 710                 715                 720 
Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu
                725                 730                 735     
Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser
            740                 745                 750         
Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe
        755                 760                 765             
Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys
    770                 775                 780                 
Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp
785                 790                 795                 800 
Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg
                805                 810                 815     
Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr
            820                 825                 830         
Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly
        835                 840                 845             
Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu
    850                 855                 860                 
Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln
865                 870                 875                 880 
Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys
                885                 890                 895     
Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro
            900                 905                 910         
Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala
        915                 920                 925             
Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile
    930                 935                 940                 
Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu
945                 950                 955                 960 
Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro
                965                 970                 975     
Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val
            980                 985                 990         
Ala His Phe His Lys Glu Val Phe Gly Thr Phe Gly Ile Pro Phe Leu
        995                 1000                1005            
Leu Arg Ile His Gln Gly Glu His Phe Arg Glu Val Met Lys Arg Ile
    1010                1015                1020                
Gln Ser Leu Leu Asp Ile Gln Glu Lys Glu Phe Glu Lys Phe Lys Phe
1025                1030                1035                1040
Ala Ile Val Met Thr Gly Arg His Gln Tyr Ile Asn Glu Asp Glu Tyr
                1045                1050                1055    
Glu Val Asn Leu Lys Asp Phe Glu Pro Gln Pro Gly Asn Met Ser His
            1060                1065                1070        
Pro Arg Pro Trp Leu Gly Leu Asp His Phe Asn Lys Ala Pro Lys Arg
        1075                1080                1085            
Ser Arg Tyr Thr Tyr Leu Glu Lys Ala Ile Lys Ile His Asn
    1090                1095                1100        


<210> 6214
<211> 255
<212> PRT
<213> Homo sapiens

<400> 6214
Met Ala Leu Met Gln Glu Leu Tyr Ser Thr Pro Ala Ser Arg Leu Asp
 1               5                  10                  15      
Ser Phe Val Ala Gln Trp Leu Gln Pro His Arg Glu Trp Lys Glu Glu
            20                  25                  30          
Val Leu Asp Ala Val Arg Thr Val Glu Glu Phe Leu Arg Gln Glu His
        35                  40                  45              
Phe Gln Gly Lys Arg Gly Leu Asp Gln Asp Val Arg Val Leu Lys Val
    50                  55                  60                  
Val Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser Thr Arg
65                  70                  75                  80  
Glu Val Glu Leu Val Ala Phe Leu Ser Cys Phe His Ser Phe Gln Glu
                85                  90                  95      
Ala Ala Lys His His Lys Asp Val Leu Arg Leu Ile Trp Lys Thr Met
            100                 105                 110         
Trp Gln Ser Gln Asp Leu Leu Asp Leu Gly Leu Glu Asp Leu Arg Met
        115                 120                 125             
Glu Gln Arg Val Pro Asp Ala Leu Val Phe Thr Ile Gln Thr Arg Gly
    130                 135                 140                 
Thr Ala Glu Pro Ile Thr Val Thr Ile Val Pro Ala Tyr Arg Ala Leu
145                 150                 155                 160 
Gly Pro Ser Leu Pro Asn Ser Gln Pro Pro Pro Glu Val Tyr Val Ser
                165                 170                 175     
Leu Ile Lys Ala Cys Gly Gly Pro Gly Asn Phe Cys Pro Ser Phe Ser
            180                 185                 190         
Glu Leu Gln Arg Asn Phe Val Lys His Arg Pro Thr Lys Leu Lys Ser
        195                 200                 205             
Leu Leu Arg Leu Val Lys His Trp Tyr Gln Gln Ala His His Pro Gly
    210                 215                 220                 
Ser Gly Arg Pro His Pro Gln Arg Gly Arg Arg Val Gln Met Gly His
225                 230                 235                 240 
Arg Cys Ser Glu Gly Leu Pro Val Pro Glu Thr Gly Leu Leu Leu
                245                 250                 255 


<210> 6215
<211> 514
<212> PRT
<213> Homo sapiens

<400> 6215
Met Ala Leu Met Gln Glu Leu Tyr Ser Thr Pro Ala Ser Arg Leu Asp
 1               5                  10                  15      
Ser Phe Val Ala Gln Trp Leu Gln Pro His Arg Glu Trp Lys Glu Glu
            20                  25                  30          
Val Leu Asp Ala Val Arg Thr Val Glu Glu Phe Leu Arg Gln Glu His
        35                  40                  45              
Phe Gln Gly Lys Arg Gly Leu Asp Gln Asp Val Arg Val Leu Lys Val
    50                  55                  60                  
Val Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser Thr Arg
65                  70                  75                  80  
Glu Val Glu Leu Val Ala Phe Leu Ser Cys Phe His Ser Phe Gln Glu
                85                  90                  95      
Ala Ala Lys His His Lys Asp Val Leu Arg Leu Ile Trp Lys Thr Met
            100                 105                 110         
Trp Gln Ser Gln Asp Leu Leu Asp Leu Gly Leu Glu Asp Leu Arg Met
        115                 120                 125             
Glu Gln Arg Val Pro Asp Ala Leu Val Phe Thr Ile Gln Thr Arg Gly
    130                 135                 140                 
Thr Ala Glu Pro Ile Thr Val Thr Ile Val Pro Ala Tyr Arg Ala Leu
145                 150                 155                 160 
Gly Pro Ser Leu Pro Asn Ser Gln Pro Pro Pro Glu Val Tyr Val Ser
                165                 170                 175     
Leu Ile Lys Ala Cys Gly Gly Pro Gly Asn Phe Cys Pro Ser Phe Ser
            180                 185                 190         
Glu Leu Gln Arg Asn Phe Val Lys His Arg Pro Thr Lys Leu Lys Ser
        195                 200                 205             
Leu Leu Arg Leu Val Lys His Trp Tyr Gln Gln Tyr Val Lys Ala Arg
    210                 215                 220                 
Ser Pro Arg Ala Asn Leu Pro Pro Leu Tyr Ala Leu Glu Leu Leu Thr
225                 230                 235                 240 
Ile Tyr Ala Trp Glu Met Gly Thr Glu Glu Asp Glu Asn Phe Met Leu
                245                 250                 255     
Asp Glu Gly Phe Thr Thr Val Met Asp Leu Leu Leu Glu Tyr Glu Val
            260                 265                 270         
Ile Cys Ile Tyr Trp Thr Lys Tyr Tyr Thr Leu His Asn Ala Ile Ile
        275                 280                 285             
Glu Asp Cys Val Arg Lys Gln Leu Lys Lys Glu Arg Pro Ile Ile Leu
    290                 295                 300                 
Asp Pro Ala Asp Pro Thr Leu Asn Val Ala Glu Gly Tyr Arg Trp Asp
305                 310                 315                 320 
Ile Val Ala Gln Arg Ala Ser Gln Cys Leu Lys Gln Asp Cys Cys Tyr
                325                 330                 335     
Asp Asn Arg Glu Asn Pro Ile Ser Ser Trp Asn Val Lys Arg Ala Arg
            340                 345                 350         
Asp Ile His Leu Thr Val Glu Gln Arg Gly Tyr Pro Asp Phe Asn Leu
        355                 360                 365             
Ile Val Asn Pro Tyr Glu Pro Ile Arg Lys Val Lys Glu Lys Ile Arg
    370                 375                 380                 
Arg Thr Arg Gly Tyr Ser Gly Leu Gln Arg Leu Ser Phe Gln Val Pro
385                 390                 395                 400 
Gly Ser Glu Arg Gln Leu Leu Ser Ser Arg Cys Ser Leu Ala Lys Tyr
                405                 410                 415     
Gly Ile Phe Ser His Thr His Ile Tyr Leu Leu Glu Thr Ile Pro Ser
            420                 425                 430         
Glu Ile Gln Val Phe Val Lys Asn Pro Asp Gly Gly Ser Tyr Ala Tyr
        435                 440                 445             
Ala Ile Asn Pro Asn Ser Phe Ile Leu Gly Leu Lys Gln Gln Ile Glu
    450                 455                 460                 
Asp Gln Gln Gly Leu Pro Lys Lys Gln Gln Gln Leu Glu Phe Gln Gly
465                 470                 475                 480 
Gln Val Leu Gln Asp Trp Leu Gly Leu Gly Ile Tyr Gly Ile Gln Asp
                485                 490                 495     
Ser Asp Thr Leu Ile Leu Ser Lys Lys Lys Gly Glu Ala Leu Phe Pro
            500                 505                 510         
Ala Ser
        


<210> 6216
<211> 799
<212> PRT
<213> Homo sapiens

<400> 6216
Met Ser Glu Arg Thr Gln Glu Gln Asp Phe Val Ile Ile Thr Val Asp
 1               5                  10                  15      
Asp Ser Asp Asp Asn Asn Asp Cys Ser Ile Glu Met Val Glu Val Ser
            20                  25                  30          
Glu Thr Ala Asp Asn Ser Thr Asn Asp Ile Ala Asp Asp Ser Thr Tyr
        35                  40                  45              
Val Thr Ala Asp Asn Pro Thr Asp Asp Thr Ala Thr Gln Pro Asn Phe
    50                  55                  60                  
Pro Gly Gly Asn Asp Gly His His Arg Pro Leu Gln Met Ser Tyr Gly
65                  70                  75                  80  
Ser Gly Ser Val Thr Gln Ala Gly Val Gln Trp His Asp His Ser Ser
                85                  90                  95      
Leu Gln Pro Gln Pro Leu Gly Leu Lys Gln Phe Phe His Leu Ser Leu
            100                 105                 110         
Pro Ser Ser Trp Asp Asp Arg Arg Thr Pro Pro Cys Pro Val Ala His
        115                 120                 125             
Gly Asp Gln Ile Val Ser Gln Ile Asn His Pro Val His Leu Arg Arg
    130                 135                 140                 
Tyr Ser Tyr Asn Ser Glu Glu Val Asp Phe Pro Lys Arg Gly Arg Phe
145                 150                 155                 160 
Tyr Thr Pro Glu Val Gln Ser Ser Ile Ser Pro Pro Ala Glu Arg Gln
                165                 170                 175     
Glu Thr His Ala Trp Ala Ser Pro Ala Val Thr Ser Leu Glu Ser Ala
            180                 185                 190         
Ala Cys His Glu Leu Gln Glu Ala Asp Leu Ser Glu Ser Leu Ser Tyr
        195                 200                 205             
Pro Arg Ile Val Ser Ser Ser Ser Leu Gln Gln Tyr Val Ala Gln Gly
    210                 215                 220                 
Gly Ser Phe Pro Cys Phe Gly Met Pro Trp Asn Phe Ile Ser Gly Gly
225                 230                 235                 240 
Ala Glu Ser Thr Asn Ala Val Ile Ser Phe Ala Asn Ala Thr Thr Ala
                245                 250                 255     
Val Pro Met Ala Val Leu Ser Arg Arg Glu Ser Ser Leu Ala Asn Asn
            260                 265                 270         
Pro Gly Val Val Asn Tyr Ser Ala Leu Pro Glu Asn Glu Asn Val Gly
        275                 280                 285             
Pro Gly Arg Ala Leu Ser Ser Phe Cys Phe His Pro Asn Leu Glu Met
    290                 295                 300                 
Pro Glu Arg Pro Ala Asn Ser Ser Lys Asn Ser Thr Glu Thr Ala Asn
305                 310                 315                 320 
Tyr Pro Thr Leu Met Gly Asn Tyr Asn Gly Gln Asn Thr Ala Ser Leu
                325                 330                 335     
Ser Val Phe Ile Pro Pro Tyr Phe Ala Glu Lys Ile Ile Leu Thr Glu
            340                 345                 350         
Met Pro Gly Thr Thr Glu Thr Asn Val Glu Asn Asn Ser Gln Thr Val
        355                 360                 365             
Tyr Tyr Pro Ala Leu Ser Gly Asn Thr Ser Ala Pro Tyr Pro Ala Ser
    370                 375                 380                 
Ser Tyr Leu Pro Ile Thr Ser Asn Phe Glu Ser Gly Pro Gln Met Ser
385                 390                 395                 400 
Tyr Gly Thr Met Ser Tyr Ser Thr Glu Met Lys Asn Asn Cys Asp Gln
                405                 410                 415     
Asp Asp Ala Ser Ala Ser Ala Cys Leu Thr Pro Asp Phe Ala Leu Leu
            420                 425                 430         
Pro Leu Asn Ile Leu Val Lys Val Asp Thr Asn Thr Glu Asn Ser Val
        435                 440                 445             
Asn Thr Met Asn Arg Ser Thr Leu Leu Asp Ser Asp Ser Gly Gln Asp
    450                 455                 460                 
Ser Ser Ser Ser Ser Val Cys Ile Pro Pro Lys Tyr Gly Tyr Leu Gly
465                 470                 475                 480 
Asp Pro Lys Arg Asn Val Arg Val Leu Lys Ile His Leu Leu Ala Val
                485                 490                 495     
Gln Asn Met Ala Lys Pro Lys Gln Ala Ala Cys Tyr Leu Val Arg Ile
            500                 505                 510         
Leu Phe Ser Lys Glu Ile Leu Ile Ser Ser Ser Val Asp Ile His Leu
        515                 520                 525             
Lys Asp Ser Gln Ser Leu Asp Pro Asn Lys Met Ala Ala Leu Arg Glu
    530                 535                 540                 
Tyr Leu Ala Thr Thr Phe Pro Thr Cys Asp Leu His Glu His Gly Lys
545                 550                 555                 560 
Asp Trp Gln Asp Cys Ile Ser Gly Ile Asn Ser Met Ile Tyr Cys Leu
                565                 570                 575     
Cys Ser Glu Gly Lys Ser Thr Pro Lys Thr Val Arg Lys Asn Lys Lys
            580                 585                 590         
Arg Thr Asn Arg Val Ala Ser Ala Ser Ala Asp Arg Asn Asp Gln Arg
        595                 600                 605             
Gly Arg Asp Gly Gly Glu Gly Cys Ser Trp Met Phe Gln Pro Met Asn
    610                 615                 620                 
Asn Ser Lys Met Arg Val Lys Arg Asn Leu Gln Pro Asn Ser Asn Ala
625                 630                 635                 640 
Ile Pro Glu Gly Met Arg Glu Pro Ser Thr Asp Asn Pro Glu Glu Pro
                645                 650                 655     
Gly Glu Ala Trp Ser Tyr Phe Gly Arg Pro Trp Arg Asn Ile Arg Met
            660                 665                 670         
Pro Cys Ser Val Leu Thr Leu Ala Lys Thr Lys Ser Cys Ala Ser Leu
        675                 680                 685             
Ser Ala Arg Tyr Leu Ile Gln Lys Leu Phe Thr Lys Asp Val Leu Val
    690                 695                 700                 
Gln Ser Asn Val Tyr Gly Asn Leu Lys His Gly Leu Cys Ala Leu Asp
705                 710                 715                 720 
Pro Asn Lys Ile Ser Ala Leu Arg Glu Phe Leu Gln Glu Asn Tyr Pro
                725                 730                 735     
Ile Cys Asp Leu Ser Glu Asn Gly Arg Asp Trp Lys Ser Cys Val Thr
            740                 745                 750         
Ser Ile Asn Ser Gly Ile Arg Ser Leu Arg His Asp Val Arg Arg Ala
        755                 760                 765             
Glu Ala Arg Ser Gln Ser Leu Pro Ala Val Thr Pro Pro Glu Leu Glu
    770                 775                 780                 
Gln Glu Ser Lys Pro Gly Asp Pro Asp Ala Thr Asp Pro Ser Thr
785                 790                 795                 


<210> 6217
<211> 323
<212> PRT
<213> Homo sapiens

<400> 6217
Met Tyr His Asn Ser Ser Gln Lys Arg His Trp Thr Phe Ser Ser Glu
 1               5                  10                  15      
Glu Gln Leu Ala Arg Leu Arg Ala Asp Ala Asn Arg Lys Phe Arg Cys
            20                  25                  30          
Lys Ala Val Ala Asn Gly Lys Val Leu Pro Asn Asp Pro Val Phe Leu
        35                  40                  45              
Glu Pro His Glu Glu Met Thr Leu Cys Lys Tyr Tyr Glu Lys Arg Leu
    50                  55                  60                  
Leu Glu Phe Cys Ser Val Phe Lys Pro Ala Met Pro Arg Ser Val Val
65                  70                  75                  80  
Gly Thr Ala Cys Met Tyr Phe Lys Arg Phe Tyr Leu Asn Asn Ser Val
                85                  90                  95      
Met Glu Tyr His Pro Arg Ile Ile Met Leu Thr Cys Ala Phe Leu Ala
            100                 105                 110         
Cys Lys Val Asp Glu Phe Asn Val Ser Ser Pro Gln Phe Val Gly Asn
        115                 120                 125             
Leu Arg Glu Ser Pro Leu Gly Gln Glu Lys Ala Leu Glu Gln Ile Leu
    130                 135                 140                 
Glu Tyr Glu Leu Leu Leu Ile Gln Gln Leu Asn Phe His Leu Ile Val
145                 150                 155                 160 
His Asn Pro Tyr Arg Pro Phe Glu Gly Phe Leu Ile Asp Leu Lys Thr
                165                 170                 175     
Arg Tyr Pro Ile Leu Glu Asn Pro Glu Ile Leu Arg Lys Thr Ala Asp
            180                 185                 190         
Asp Phe Leu Asn Arg Ile Ala Leu Thr Asp Ala Tyr Leu Leu Tyr Thr
        195                 200                 205             
Pro Ser Gln Ile Ala Leu Thr Ala Ile Leu Ser Ser Ala Ser Arg Ala
    210                 215                 220                 
Gly Ile Thr Met Glu Ser Tyr Leu Ser Glu Ser Leu Met Leu Lys Glu
225                 230                 235                 240 
Asn Arg Thr Cys Leu Ser Gln Leu Leu Asp Ile Met Lys Ser Met Arg
                245                 250                 255     
Asn Leu Val Lys Lys Tyr Glu Pro Pro Arg Ser Glu Glu Val Ala Val
            260                 265                 270         
Leu Lys Gln Lys Leu Glu Arg Cys His Ser Ala Glu Leu Ala Leu Asn
        275                 280                 285             
Val Ile Thr Lys Lys Arg Lys Gly Tyr Glu Asp Asp Asp Tyr Val Ser
    290                 295                 300                 
Lys Lys Ser Lys His Glu Glu Glu Glu Trp Thr Asp Asp Asp Leu Val
305                 310                 315                 320 
Glu Ser Leu
            


<210> 6218
<211> 623
<212> PRT
<213> Homo sapiens

<400> 6218
Met Asn Arg Tyr Thr Thr Met Arg Gln Leu Gly Asp Gly Thr Tyr Gly
 1               5                  10                  15      
Ser Val Leu Met Gly Lys Ser Asn Glu Ser Gly Glu Leu Val Ala Ile
            20                  25                  30          
Lys Arg Met Lys Arg Lys Phe Tyr Ser Trp Asp Glu Cys Met Asn Leu
        35                  40                  45              
Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Ile Lys
    50                  55                  60                  
Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu
65                  70                  75                  80  
Tyr Met Lys Glu Asn Leu Tyr Gln Leu Met Lys Asp Arg Asn Lys Leu
                85                  90                  95      
Phe Pro Glu Ser Val Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly
            100                 105                 110         
Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Met Lys Pro
        115                 120                 125             
Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe
    130                 135                 140                 
Gly Leu Ala Arg Glu Leu Arg Ser Gln Pro Pro Tyr Thr Asp Tyr Val
145                 150                 155                 160 
Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Ser Val
                165                 170                 175     
Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Ser Ile Met Ala Glu
            180                 185                 190         
Leu Tyr Met Leu Arg Pro Leu Phe Pro Gly Thr Ser Glu Val Asp Glu
        195                 200                 205             
Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Ser Asp Trp
    210                 215                 220                 
Pro Glu Gly Tyr Gln Leu Ala Ser Ser Met Asn Phe Arg Phe Pro Gln
225                 230                 235                 240 
Cys Val Pro Ile Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Asn Glu
                245                 250                 255     
Ala Ile Gln Leu Met Thr Glu Met Leu Asn Trp Asp Pro Lys Lys Arg
            260                 265                 270         
Pro Thr Ala Ser Gln Ala Leu Lys His Pro Tyr Phe Gln Val Gly Gln
        275                 280                 285             
Val Leu Gly Pro Ser Ser Asn His Leu Glu Ser Lys Gln Ser Leu Asn
    290                 295                 300                 
Lys Gln Leu Gln Pro Leu Glu Ser Lys Pro Ser Leu Val Glu Val Glu
305                 310                 315                 320 
Pro Lys Pro Leu Pro Asp Ile Ile Asp Gln Val Val Gly Gln Pro Gln
                325                 330                 335     
Pro Lys Thr Ser Gln Gln Pro Leu Gln Pro Ile Gln Pro Pro Gln Asn
            340                 345                 350         
Leu Ser Val Gln Gln Pro Pro Lys Gln Gln Ser Gln Glu Lys Pro Pro
        355                 360                 365             
Gln Thr Leu Phe Pro Ser Ile Val Lys Asn Met Pro Thr Lys Pro Asn
    370                 375                 380                 
Gly Thr Leu Ser His Lys Ser Gly Arg Arg Arg Trp Gly Gln Thr Ile
385                 390                 395                 400 
Phe Lys Ser Gly Asp Ser Trp Glu Glu Leu Glu Asp Tyr Asp Phe Gly
                405                 410                 415     
Ala Ser His Ser Lys Lys Pro Ser Met Gly Val Phe Lys Glu Lys Arg
            420                 425                 430         
Lys Lys Asp Ser Pro Phe Arg Leu Pro Glu Pro Val Pro Ser Gly Ser
        435                 440                 445             
Asn His Ser Thr Gly Glu Asn Lys Ser Leu Pro Ala Val Thr Ser Leu
    450                 455                 460                 
Lys Ser Asp Ser Glu Leu Ser Thr Ala Pro Thr Ser Lys Gln Tyr Tyr
465                 470                 475                 480 
Leu Lys Gln Ser Arg Tyr Leu Pro Gly Val Asn Pro Lys Lys Val Ser
                485                 490                 495     
Leu Ile Ala Ser Gly Lys Glu Ile Asn Pro His Thr Trp Ser Asn Gln
            500                 505                 510         
Leu Phe Pro Lys Ser Leu Gly Pro Val Gly Ala Glu Leu Ala Phe Lys
        515                 520                 525             
Arg Ser Asn Ala Gly Asn Leu Gly Ser Tyr Ala Thr Tyr Asn Gln Ser
    530                 535                 540                 
Gly Tyr Ile Pro Ser Phe Leu Lys Lys Glu Val Gln Ser Ala Gly Gln
545                 550                 555                 560 
Arg Ile His Leu Ala Pro Leu Asn Ala Thr Ala Ser Glu Tyr Thr Trp
                565                 570                 575     
Asn Thr Lys Thr Gly Arg Gly Gln Phe Ser Gly Arg Thr Tyr Asn Pro
            580                 585                 590         
Thr Ala Lys Asn Leu Asn Ile Val Asn Arg Ala Gln Pro Ile Pro Ser
        595                 600                 605             
Val His Gly Arg Thr Asp Trp Val Ala Lys Tyr Gly Gly His Arg
    610                 615                 620             


<210> 6219
<211> 666
<212> PRT
<213> Homo sapiens

<400> 6219
Met Ser Pro Thr Pro Pro Leu Phe Ser Leu Pro Glu Ala Arg Thr Arg
 1               5                  10                  15      
Phe Thr Lys Ser Thr Arg Glu Ala Leu Asn Asn Lys Asn Ile Lys Pro
            20                  25                  30          
Leu Leu Ser Thr Phe Ser Gln Val Pro Gly Ser Glu Asn Glu Lys Lys
        35                  40                  45              
Cys Thr Leu Asp Gln Ala Phe Arg Gly Ile Leu Glu Glu Glu Ile Ile
    50                  55                  60                  
Asn His Ser Ser Cys Glu Asn Val Leu Ala Ile Ile Ser Leu Ala Ile
65                  70                  75                  80  
Gly Gly Val Thr Glu Gly Ile Cys Thr Ala Ser Thr Pro Phe Val Leu
                85                  90                  95      
Leu Gly Asp Val Leu Asp Cys Leu Pro Leu Asp Gln Cys Asp Thr Ile
            100                 105                 110         
Phe Thr Phe Val Glu Lys Asn Val Ala Thr Trp Lys Ser Asn Thr Phe
        115                 120                 125             
Tyr Ser Ala Gly Lys Asn Tyr Leu Leu Arg Met Cys Asn Asp Leu Leu
    130                 135                 140                 
Arg Arg Leu Ser Lys Ser Gln Asn Thr Val Phe Cys Gly Arg Ile Gln
145                 150                 155                 160 
Leu Phe Leu Ala Arg Leu Phe Pro Leu Ser Glu Lys Ser Gly Leu Asn
                165                 170                 175     
Leu Gln Ser Gln Phe Asn Leu Glu Asn Val Thr Val Phe Asn Thr Asn
            180                 185                 190         
Glu Gln Glu Ser Thr Leu Gly Gln Lys His Thr Glu Asp Arg Glu Glu
        195                 200                 205             
Gly Met Asp Val Glu Glu Gly Glu Met Gly Asp Glu Glu Ala Pro Thr
    210                 215                 220                 
Thr Cys Ser Ile Pro Ile Asp Tyr Asn Leu Tyr Arg Lys Phe Trp Ser
225                 230                 235                 240 
Leu Gln Asp Tyr Phe Arg Asn Pro Val Gln Cys Tyr Glu Lys Ile Ser
                245                 250                 255     
Trp Lys Thr Phe Leu Lys Tyr Ser Glu Glu Val Leu Ala Val Phe Lys
            260                 265                 270         
Ser Tyr Lys Leu Asp Asp Thr Gln Ala Ser Arg Lys Lys Met Glu Glu
        275                 280                 285             
Leu Lys Thr Gly Gly Glu His Val Tyr Phe Ala Lys Phe Leu Thr Ser
    290                 295                 300                 
Glu Lys Leu Met Asp Leu Gln Leu Ser Asp Ser Asn Phe Arg Arg His
305                 310                 315                 320 
Ile Leu Leu Gln Tyr Leu Ile Leu Phe Gln Tyr Leu Lys Gly Gln Val
                325                 330                 335     
Lys Phe Lys Ser Ser Asn Tyr Val Leu Thr Asp Glu Gln Ser Leu Trp
            340                 345                 350         
Ile Glu Asp Thr Thr Lys Ser Val Tyr Gln Leu Leu Ser Glu Asn Pro
        355                 360                 365             
Pro Asp Gly Glu Arg Phe Ser Lys Met Val Glu His Ile Leu Asn Thr
    370                 375                 380                 
Glu Glu Asn Trp Asn Ser Trp Lys Asn Glu Gly Cys Pro Ser Phe Val
385                 390                 395                 400 
Lys Glu Arg Thr Ser Asp Thr Lys Pro Thr Arg Ile Ile Arg Lys Arg
                405                 410                 415     
Thr Ala Pro Glu Asp Phe Leu Gly Lys Gly Pro Thr Lys Lys Ile Leu
            420                 425                 430         
Met Gly Asn Glu Glu Leu Thr Arg Leu Trp Asn Leu Cys Pro Asp Asn
        435                 440                 445             
Met Glu Ala Cys Lys Ser Glu Thr Arg Gln Val Glu His Phe Ser Asn
    450                 455                 460                 
Glu Val Glu His Met Pro Thr Leu Glu Glu Phe Phe Glu Glu Ala Ile
465                 470                 475                 480 
Glu Gln Ala Asp Pro Glu Asn Met Val Glu Asn Glu Tyr Lys Ala Val
                485                 490                 495     
Asn Asn Ser Asn Tyr Gly Trp Arg Ala Leu Arg Leu Leu Ala Arg Arg
            500                 505                 510         
Ser Pro His Phe Phe Gln Pro Thr Asn Gln Gln Phe Lys Ser Leu Pro
        515                 520                 525             
Glu Tyr Leu Glu Asn Met Val Ile Lys Leu Ala Lys Glu Leu Pro Pro
    530                 535                 540                 
Pro Ser Glu Glu Ile Lys Thr Gly Glu Asp Glu Asp Glu Glu Asp Asn
545                 550                 555                 560 
Asp Ala Leu Leu Lys Glu Asn Glu Ser Pro Asp Val Arg Arg Asp Lys
                565                 570                 575     
Pro Val Thr Gly Glu Gln Ile Glu Val Phe Ala Asn Lys Leu Gly Glu
            580                 585                 590         
Gln Trp Lys Ile Leu Ala Pro Tyr Leu Glu Met Lys Asp Ser Glu Ile
        595                 600                 605             
Arg Gln Ile Glu Cys Asp Ser Glu Asp Met Lys Met Arg Ala Lys Gln
    610                 615                 620                 
Leu Leu Val Ala Trp Gln Asp Gln Glu Gly Val His Ala Thr Pro Glu
625                 630                 635                 640 
Asn Leu Ile Asn Ala Leu Asn Lys Ser Gly Leu Ser Asp Leu Ala Glu
                645                 650                 655     
Ser Leu Thr Asn Asp Asn Glu Thr Asn Ser
            660                 665     


<210> 6220
<211> 502
<212> PRT
<213> Homo sapiens

<400> 6220
Val Cys Tyr Arg Lys Leu His His Leu Gln Val Ile Ile Leu Asp Asn
 1               5                  10                  15      
Asn Pro Leu Gln Val Pro Pro Ala Gln Ile Cys Leu Lys Gly Lys Val
            20                  25                  30          
His Ile Phe Lys Tyr Leu Asn Ile Gln Ala Cys Cys Arg Met Asp Lys
        35                  40                  45              
Lys Pro Asp Ser Leu Asp Leu Pro Ser Leu Ser Lys Arg Met Pro Ser
    50                  55                  60                  
Gln Pro Leu Thr Asp Ser Met Glu Asp Phe Tyr Pro Asn Lys Asn His
65                  70                  75                  80  
Gly Pro Asp Ser Gly Ile Gly Ser Asp Asn Gly Glu Lys Arg Leu Ser
                85                  90                  95      
Thr Thr Glu Pro Ser Asp Asp Asp Thr Val Ser Leu His Ser Gln Val
            100                 105                 110         
Ser Glu Ser Asn Arg Glu Gln Thr Ser Arg Asn Asp Ser His Ile Ile
        115                 120                 125             
Gly Ser Lys Thr Asp Ser Gln Lys Asp Gln Glu Val Tyr Asp Phe Val
    130                 135                 140                 
Asp Pro Asn Thr Glu Asp Val Ala Val Pro Glu Gln Gly Asn Ala His
145                 150                 155                 160 
Ile Gly Ser Phe Val Ser Phe Phe Lys Gly Lys Glu Lys Cys Ser Glu
                165                 170                 175     
Lys Ser Arg Lys Asn Glu Glu Leu Gly Asp Glu Lys Arg Leu Glu Lys
            180                 185                 190         
Glu Gln Leu Leu Ala Glu Glu Glu Asp Asp Asp Leu Lys Glu Val Thr
        195                 200                 205             
Asp Leu Arg Lys Ile Ala Ala Gln Leu Leu Gln Gln Glu Gln Lys Asn
    210                 215                 220                 
Arg Ile Leu Asn His Ser Thr Ser Val Met Arg Asn Lys Pro Lys Gln
225                 230                 235                 240 
Thr Val Glu Cys Glu Lys Ser Val Ser Ala Asp Glu Val Asn Ser Pro
                245                 250                 255     
Leu Ser Pro Leu Thr Trp Gln Pro Leu Glu Asn Gln Lys Asp Gln Ile
            260                 265                 270         
Asp Glu Gln Pro Trp Pro Glu Ser His Pro Ile Ile Trp Gln Ser Glu
        275                 280                 285             
Glu Arg Arg Arg Ser Lys Gln Ile Arg Lys Glu Tyr Phe Lys Tyr Lys
    290                 295                 300                 
Ser Met Arg Lys Ser Ser Ser Gly Asn Glu Asn Asp Glu Gln Asp Ser
305                 310                 315                 320 
Asp Asn Ala Asn Met Ser Thr Gln Ser Pro Val Ser Ser Glu Glu Tyr
                325                 330                 335     
Asp Arg Thr Asp Gly Phe Ser His Ser Pro Phe Gly Leu Lys Pro Arg
            340                 345                 350         
Ser Ala Phe Ser Arg Ser Ser Arg Gln Glu Tyr Gly Ala Ala Asp Pro
        355                 360                 365             
Gly Phe Thr Met Arg Arg Lys Met Glu His Leu Arg Glu Glu Arg Glu
    370                 375                 380                 
Gln Ile Arg Gln Leu Arg Asn Asn Leu Glu Ser Arg Leu Lys Val Ile
385                 390                 395                 400 
Leu Pro Asp Asp Ile Gly Ala Ala Leu Met Asp Gly Val Val Leu Cys
                405                 410                 415     
His Leu Ala Asn His Ile Arg Pro Arg Ser Val Ala Ser Ile His Val
            420                 425                 430         
Pro Ser Pro Ala Val Pro Lys Leu Ser Met Ala Lys Cys Arg Arg Asn
        435                 440                 445             
Val Glu Asn Phe Leu Asp Ala Cys Lys Lys Leu Gly Val Ser Gln Glu
    450                 455                 460                 
Arg Leu Cys Leu Pro His His Ile Leu Glu Glu Arg Gly Leu Val Lys
465                 470                 475                 480 
Val Gly Val Thr Val Gln Ala Leu Leu Glu Leu Pro Thr Thr Lys Ala
                485                 490                 495     
Ser Gln Leu Ser Val Ala
            500         


<210> 6221
<211> 1531
<212> PRT
<213> Homo sapiens

<400> 6221
Met Gln Val Asn Thr Leu Phe Glu Thr Ser Gln Val Pro Asp Trp Ser
 1               5                  10                  15      
Asp Pro Pro Gln Val Gln Val Gln Glu Thr Val Arg Glu Thr Ile Ser
            20                  25                  30          
Cys Ser Gln Met Pro Ala Phe Ser Glu Pro Ala Gly Glu Glu Ser Pro
        35                  40                  45              
Phe Thr Gly Thr Thr Thr Ile Ser Phe Ser Asn Leu Gly Gly Val His
    50                  55                  60                  
Lys Glu Asn Ala Ser Leu Ala Gln His Ser Glu Val Lys Pro Cys Thr
65                  70                  75                  80  
Cys Gly Pro Gln Gln Glu Glu Lys Gln Asp Arg Asp Gly Asn Ile Pro
                85                  90                  95      
Asp Asn Phe Arg Glu Asp Leu Lys Tyr Glu Gln Ser Ile Ser Glu Ala
            100                 105                 110         
Asn Asp Glu Thr Met Ser Pro Gly Val Phe Ser Arg His Leu Pro Lys
        115                 120                 125             
Asp Ala Arg Ala Asp Phe Arg Glu Pro Val Ala Val Ser Val Ala Ser
    130                 135                 140                 
Pro Glu Pro Thr Asp Thr Ala Leu Thr Leu Glu Asn Val Cys Asp Glu
145                 150                 155                 160 
Pro Arg Asp Arg Glu Ala Val Cys Ala Met Glu Cys Phe Glu Ala Ser
                165                 170                 175     
Asp Gln Gly Thr Cys Phe Asp Thr Ile Asp Ser Leu Val Gly Thr Pro
            180                 185                 190         
Val Asp Asn Tyr Ser Pro Gln Glu Ile Cys Ser Val Asp Thr Glu Leu
        195                 200                 205             
Ala Glu Gly Gln Asn Lys Val Ser Asp Leu Cys Ser Ser Asn Asp Lys
    210                 215                 220                 
Thr Leu Glu Val Phe Phe Gln Thr Gln Val Ser Glu Thr Ser Val Ser
225                 230                 235                 240 
Thr Cys Lys Ser Ser Lys Asp Gly Asn Ser Val Met Ser Pro Leu Phe
                245                 250                 255     
Ile Ser Thr Phe Thr Leu Asn Ile Ser His Thr Ala Ser Glu Gly Ala
            260                 265                 270         
Thr Gly Glu Asn Leu Ala Lys Val Glu Lys Ser Thr Tyr Pro Leu Ala
        275                 280                 285             
Ser Thr Val His Ala Gly Gln Glu Gln Pro Ser Pro Ser Asn Ser Gly
    290                 295                 300                 
Gly Leu Asp Glu Thr Gln Leu Leu Ser Ser Glu Asn Asn Pro Leu Val
305                 310                 315                 320 
Gln Phe Lys Glu Gly Gly Asp Lys Ser Pro Ser Pro Ser Ala Ala Asp
                325                 330                 335     
Thr Thr Ala Thr Pro Ala Ser Tyr Ser Ser Ile Val Ser Phe Pro Trp
            340                 345                 350         
Glu Lys Pro Thr Thr Leu Thr Ala Asn Asn Glu Cys Phe Gln Ala Thr
        355                 360                 365             
Arg Glu Thr Val Thr Ile Ala Thr Glu Val His Pro Ala Lys Tyr Leu
    370                 375                 380                 
Ala Val Ser Ile Pro Glu Asp Lys His Ala Gly Gly Thr Glu Glu Arg
385                 390                 395                 400 
Phe Pro Arg Ala Ser His Glu Lys Val Ser Gln Phe Pro Ser Gln Val
                405                 410                 415     
Gln Val Asp His Ile Leu Ser Gly Ala Thr Ile Lys Ser Thr Lys Glu
            420                 425                 430         
Leu Leu Cys Arg Ala Pro Ser Val Pro Gly Val Pro His His Val Leu
        435                 440                 445             
Gln Leu Pro Glu Gly Glu Gly Phe Cys Ser Asn Ser Pro Leu Gln Val
    450                 455                 460                 
Asp Asn Leu Ser Gly Asp Lys Ser Gln Thr Val Asp Arg Ala Asp Phe
465                 470                 475                 480 
Arg Ser Tyr Glu Glu Asn Phe Gln Glu Arg Gly Ser Glu Thr Lys Gln
                485                 490                 495     
Gly Val Gln Gln Gln Ser Leu Ser Gln Gln Gly Ser Leu Ser Ala Pro
            500                 505                 510         
Asp Phe Gln Gln Ser Leu Pro Thr Thr Ser Ala Ala Gln Glu Glu Arg
        515                 520                 525             
Asn Leu Val Pro Thr Ala Pro Ser Pro Ala Ser Ser Arg Glu Gly Ala
    530                 535                 540                 
Gly Gln Arg Ser Gly Trp Gly Thr Arg Val Ser Val Val Ala Glu Thr
545                 550                 555                 560 
Ala Gly Glu Glu Asp Ser Gln Ala Leu Ser Asn Val Pro Ser Leu Ser
                565                 570                 575     
Asp Ile Leu Leu Glu Glu Ser Lys Glu Tyr Arg Pro Gly Asn Trp Glu
            580                 585                 590         
Ala Gly Asn Lys Leu Lys Ile Ile Thr Leu Glu Ala Ser Ala Ser Glu
        595                 600                 605             
Ile Trp Pro Pro Arg Gln Leu Thr Asn Ser Glu Ser Lys Ala Ser Asp
    610                 615                 620                 
Gly Gly Leu Ile Ile Pro Asp Lys Val Trp Ala Val Pro Asp Ser Leu
625                 630                 635                 640 
Lys Ala Asp Ala Val Val Pro Glu Leu Ala Pro Ser Glu Ile Ala Ala
                645                 650                 655     
Leu Ala His Ser Pro Glu Asp Ala Glu Ser Ala Leu Ala Asp Ser Arg
            660                 665                 670         
Glu Ser His Lys Gly Glu Glu Pro Thr Ile Ser Val His Trp Arg Ser
        675                 680                 685             
Leu Ser Ser Arg Gly Phe Ser Gln Pro Arg Leu Leu Glu Ser Ser Val
    690                 695                 700                 
Asp Pro Val Asp Glu Lys Glu Leu Ser Val Thr Asp Ser Leu Ser Ala
705                 710                 715                 720 
Ala Ser Glu Thr Gly Gly Lys Glu Asn Val Asn Asn Val Ser Gln Asp
                725                 730                 735     
Gln Glu Glu Lys Gln Leu Lys Met Asp His Thr Ala Phe Phe Lys Lys
            740                 745                 750         
Phe Leu Thr Cys Pro Lys Ile Leu Glu Ser Ser Val Asp Pro Ile Asp
        755                 760                 765             
Glu Ile Ser Val Ile Glu Tyr Thr Arg Ala Gly Lys Pro Glu Pro Ser
    770                 775                 780                 
Glu Thr Thr Pro Gln Gly Ala Arg Glu Gly Gly Gln Ser Asn Asp Gly
785                 790                 795                 800 
Asn Met Gly His Glu Ala Glu Ile Gln Ser Ala Ile Leu Gln Val Pro
                805                 810                 815     
Cys Leu Gln Gly Thr Ile Leu Ser Glu Asn Arg Ile Ser Arg Ser Gln
            820                 825                 830         
Glu Gly Ser Met Lys Gln Glu Ala Glu Gln Ile Gln Pro Glu Glu Ala
        835                 840                 845             
Lys Thr Ala Ile Trp Gln Val Leu Gln Pro Ser Glu Gly Gly Glu Arg
    850                 855                 860                 
Ile Pro Ser Gly Cys Ser Ile Gly Gln Ile Gln Glu Ser Ser Asp Gly
865                 870                 875                 880 
Ser Leu Gly Glu Ala Glu Gln Ser Lys Lys Asp Lys Ala Glu Leu Ile
                885                 890                 895     
Ser Pro Thr Ser Pro Leu Ser Ser Cys Leu Pro Ile Met Thr His Ser
            900                 905                 910         
Ser Leu Gly Val Asp Thr His Asn Ser Thr Gly Gln Ile His Asp Val
        915                 920                 925             
Pro Glu Asn Asp Ile Val Glu Pro Arg Lys Arg Gln Tyr Val Phe Pro
    930                 935                 940                 
Val Ser Gln Lys Arg Gly Thr Ile Glu Asn Glu Arg Gly Lys Pro Leu
945                 950                 955                 960 
Pro Ser Ser Pro Asp Leu Thr Arg Phe Pro Cys Thr Ser Ser Pro Glu
                965                 970                 975     
Gly Asn Val Thr Asp Phe Leu Ile Ser His Lys Met Glu Glu Pro Lys
            980                 985                 990         
Ile Glu Val Leu Gln Ile Gly Glu Thr Lys Pro Pro Ser Ser Ser Ser
        995                 1000                1005            
Ser Ser Ala Lys Thr Leu Ala Phe Ile Ser Gly Glu Arg Glu Leu Glu
    1010                1015                1020                
Lys Ala Pro Lys Leu Leu Gln Asp Pro Cys Gln Lys Gly Thr Leu Gly
1025                1030                1035                1040
Cys Ala Lys Lys Ser Arg Glu Arg Glu Lys Ser Leu Glu Ala Arg Ala
                1045                1050                1055    
Gly Lys Ser Pro Gly Thr Leu Thr Ala Val Thr Gly Ser Glu Glu Val
            1060                1065                1070        
Lys Arg Lys Pro Glu Ala Pro Gly Ser Gly His Leu Ala Glu Gly Val
        1075                1080                1085            
Lys Lys Lys Ile Leu Ser Arg Val Ala Ala Leu Arg Leu Lys Leu Glu
    1090                1095                1100                
Glu Lys Glu Asn Ile Arg Lys Asn Ser Ala Phe Leu Lys Lys Met Pro
1105                1110                1115                1120
Lys Leu Glu Thr Ser Leu Ser His Thr Glu Glu Lys Gln Asp Pro Lys
                1125                1130                1135    
Lys Pro Ser Cys Lys Arg Glu Gly Arg Ala Pro Val Leu Leu Lys Lys
            1140                1145                1150        
Ile Gln Ala Glu Met Phe Pro Glu His Ser Gly Asn Val Lys Leu Ser
        1155                1160                1165            
Cys Gln Phe Ala Glu Ile His Glu Asp Ser Thr Ile Cys Trp Thr Lys
    1170                1175                1180                
Asp Ser Lys Ser Ile Ala Gln Val Gln Arg Ser Ala Gly Asp Asn Ser
1185                1190                1195                1200
Thr Val Ser Phe Ala Ile Val Gln Ala Ser Pro Lys Asp Gln Gly Leu
                1205                1210                1215    
Tyr Tyr Cys Cys Ile Lys Asn Ser Tyr Gly Lys Val Thr Ala Glu Phe
            1220                1225                1230        
Asn Leu Thr Ala Glu Val Leu Lys Gln Leu Ser Ser Arg Gln Asp Thr
        1235                1240                1245            
Lys Gly Cys Glu Glu Ile Glu Phe Ser Gln Leu Ile Phe Lys Glu Asp
    1250                1255                1260                
Phe Leu His Asp Ser Tyr Phe Gly Gly Arg Leu Arg Gly Gln Ile Ala
1265                1270                1275                1280
Thr Glu Glu Leu His Phe Gly Glu Gly Val His Arg Lys Ala Phe Arg
                1285                1290                1295    
Ser Thr Val Met His Gly Leu Met Pro Val Phe Lys Pro Gly His Ala
            1300                1305                1310        
Cys Val Leu Lys Val His Asn Ala Ile Ala Tyr Gly Thr Arg Asn Asn
        1315                1320                1325            
Asp Glu Leu Ile Gln Arg Asn Tyr Lys Leu Ala Ala Gln Glu Cys Tyr
    1330                1335                1340                
Val Gln Asn Thr Ala Arg Tyr Tyr Ala Lys Ile Tyr Ala Ala Glu Ala
1345                1350                1355                1360
Gln Pro Leu Glu Gly Phe Gly Glu Val Pro Glu Ile Ile Pro Ile Phe
                1365                1370                1375    
Leu Ile His Arg Pro Glu Asn Asn Ile Pro Tyr Ala Thr Val Glu Glu
            1380                1385                1390        
Glu Leu Ile Gly Glu Phe Val Lys Tyr Ser Ile Arg Asp Gly Lys Glu
        1395                1400                1405            
Ile Asn Phe Leu Arg Arg Glu Ser Glu Ala Gly Gln Lys Cys Cys Thr
    1410                1415                1420                
Phe Gln His Trp Val Tyr Gln Lys Thr Ser Gly Cys Leu Leu Val Thr
1425                1430                1435                1440
Asp Met Gln Gly Val Gly Met Lys Leu Thr Asp Val Gly Ile Ala Thr
                1445                1450                1455    
Leu Ala Lys Gly Tyr Lys Gly Phe Lys Gly Asn Cys Ser Met Thr Phe
            1460                1465                1470        
Ile Asp Gln Phe Lys Ala Leu His Gln Cys Asn Lys Tyr Cys Lys Met
        1475                1480                1485            
Leu Gly Leu Lys Ser Leu Gln Asn Asn Asn Gln Lys Gln Lys Gln Pro
    1490                1495                1500                
Ser Ile Gly Lys Ser Lys Val Gln Thr Asn Ser Met Thr Val Lys Lys
1505                1510                1515                1520
Ala Gly Pro Glu Thr Pro Gly Glu Lys Lys Thr
                1525                1530    


<210> 6222
<211> 750
<212> PRT
<213> Homo sapiens

<400> 6222
Ala Val Arg Ala Glu Pro Gly Leu Glu Glu Leu Ser Ser Gly Leu Arg
 1               5                  10                  15      
Ala His Ser Pro Ser Ala Thr Thr Val Cys Glu Pro Glu Ala Gln Gly
            20                  25                  30          
Ser Ala Ser Gly Cys Arg Tyr Ala Ala His Pro His Trp Gly Leu Gly
        35                  40                  45              
Gly Ala Ala Ala Ala Gly Gly Ser Trp Glu Pro Gln Pro Pro Arg Pro
    50                  55                  60                  
Val Cys Glu Pro Ala Gly Arg Gly Lys Pro His Pro Pro Ala Ala Pro
65                  70                  75                  80  
Arg Ser Pro Leu Leu Pro Gly Ser Arg Arg Arg Pro Gln Ala Ala Gln
                85                  90                  95      
Pro Gly Ala Arg Ala Arg Thr Ser Pro Pro Pro Ala Ser Ala Arg Asn
            100                 105                 110         
Met Ala Ala Arg Pro Ala Ala Thr Leu Ala Trp Ser Leu Leu Leu Leu
        115                 120                 125             
Ser Ser Ala Leu Leu Arg Glu Gly Cys Arg Ala Arg Phe Val Ala Glu
    130                 135                 140                 
Arg Asp Ser Glu Asp Asp Gly Glu Glu Pro Val Val Phe Pro Glu Ser
145                 150                 155                 160 
Pro Leu Gln Ser Pro Thr Val Leu Val Ala Val Leu Ala Arg Asn Ala
                165                 170                 175     
Ala His Thr Leu Pro His Phe Leu Gly Cys Leu Glu Arg Leu Asp Tyr
            180                 185                 190         
Pro Lys Ser Arg Met Ala Ile Trp Ala Ala Thr Asp His Asn Val Asp
        195                 200                 205             
Asn Thr Thr Glu Ile Phe Arg Glu Trp Leu Lys Asn Val Gln Arg Leu
    210                 215                 220                 
Tyr His Tyr Val Glu Trp Arg Pro Met Asp Glu Pro Glu Ser Tyr Pro
225                 230                 235                 240 
Asp Glu Ile Gly Pro Lys His Trp Pro Thr Ser Arg Phe Ala His Val
                245                 250                 255     
Met Lys Leu Arg Gln Ala Ala Leu Arg Thr Ala Arg Glu Lys Trp Ser
            260                 265                 270         
Asp Tyr Ile Leu Phe Ile Asp Val Asp Asn Phe Leu Thr Asn Pro Gln
        275                 280                 285             
Thr Leu Asn Leu Leu Ile Ala Glu Asn Lys Thr Ile Val Ala Pro Met
    290                 295                 300                 
Leu Glu Ser Arg Gly Leu Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro
305                 310                 315                 320 
Lys Ala Lys Asn Thr Thr His Leu Phe Ala Leu Leu Gln Gly Phe Tyr
                325                 330                 335     
Lys Arg Thr Pro Asp Tyr Val Gln Ile Arg Glu Trp Lys Arg Thr Gly
            340                 345                 350         
Cys Phe Pro Val Pro Met Val His Ser Thr Phe Leu Ile Asp Leu Arg
        355                 360                 365             
Lys Glu Ala Ser Asp Lys Leu Thr Phe Tyr Pro Pro His Gln Asp Tyr
    370                 375                 380                 
Thr Trp Thr Phe Asp Asp Ile Ile Val Phe Ala Phe Ser Ser Arg Gln
385                 390                 395                 400 
Ala Gly Ile Gln Met Tyr Leu Cys Asn Arg Glu His Tyr Gly Tyr Leu
                405                 410                 415     
Pro Ile Pro Leu Lys Pro His Gln Thr Leu Gln Glu Asp Ile Glu Asn
            420                 425                 430         
Leu Ile His Val Gln Ile Glu Ala Met Ile Asp Arg Pro Pro Met Glu
        435                 440                 445             
Pro Ser Gln Tyr Val Ser Val Val Pro Lys Tyr Pro Asp Lys Met Gly
    450                 455                 460                 
Phe Asp Glu Ile Phe Met Ile Asn Leu Lys Arg Arg Lys Asp Arg Arg
465                 470                 475                 480 
Asp Arg Met Leu Arg Thr Leu Tyr Glu Gln Glu Ile Glu Val Lys Ile
                485                 490                 495     
Val Glu Ala Val Asp Gly Lys Ala Leu Asn Thr Ser Gln Leu Lys Ala
            500                 505                 510         
Leu Asn Ile Glu Met Leu Pro Gly Tyr Arg Asp Pro Tyr Ser Ser Arg
        515                 520                 525             
Pro Leu Thr Arg Gly Glu Ile Gly Cys Phe Leu Ser His Tyr Ser Val
    530                 535                 540                 
Trp Lys Glu Val Ile Asp Arg Glu Leu Glu Lys Thr Leu Val Ile Glu
545                 550                 555                 560 
Asp Asp Val Arg Phe Glu His Gln Phe Lys Lys Lys Leu Met Lys Leu
                565                 570                 575     
Met Asp Asn Ile Asp Gln Ala Gln Leu Asp Trp Glu Leu Ile Tyr Ile
            580                 585                 590         
Gly Arg Lys Arg Met Gln Val Lys Glu Pro Glu Lys Ala Val Pro Asn
        595                 600                 605             
Val Ala Asn Leu Val Glu Ala Asp Tyr Ser Tyr Trp Thr Leu Gly Tyr
    610                 615                 620                 
Val Ile Ser Leu Glu Gly Ala Gln Lys Leu Val Gly Ala Asn Pro Phe
625                 630                 635                 640 
Gly Lys Met Leu Pro Val Asp Glu Phe Leu Pro Val Met Tyr Asn Lys
                645                 650                 655     
His Pro Val Ala Glu Tyr Lys Glu Tyr Tyr Glu Ser Arg Asp Leu Lys
            660                 665                 670         
Ala Phe Ser Ala Glu Pro Leu Leu Ile Tyr Pro Thr His Tyr Thr Gly
        675                 680                 685             
Gln Pro Gly Tyr Leu Ser Asp Thr Glu Thr Ser Thr Ile Trp Asp Asn
    690                 695                 700                 
Glu Thr Val Ala Thr Asp Trp Asp Arg Thr His Ala Trp Lys Ser Arg
705                 710                 715                 720 
Lys Gln Ser Arg Ile Tyr Ser Asn Ala Lys Asn Thr Glu Ala Leu Pro
                725                 730                 735     
Pro Pro Thr Ser Leu Asp Thr Val Pro Ser Arg Asp Glu Leu
            740                 745                 750 


<210> 6223
<211> 395
<212> PRT
<213> Homo sapiens

<400> 6223
Met Glu Ser Lys Arg Leu Arg Leu Leu Gln Glu Glu Asp Arg Arg Lys
 1               5                  10                  15      
Lys Ile Ala Arg Met Gly Phe Asn Ala Ser Ser Met Leu Arg Lys Ser
            20                  25                  30          
Gln Leu Gly Phe Leu Asn Val Thr Asn Tyr Cys His Leu Ala His Glu
        35                  40                  45              
Leu Arg Leu Ser Cys Met Glu Arg Lys Lys Val Gln Ile Arg Ser Met
    50                  55                  60                  
Asp Pro Ser Ala Leu Ala Ser Asp Arg Phe Asn Leu Ile Leu Ala Asp
65                  70                  75                  80  
Thr Asn Ser Asp Arg Leu Phe Thr Val Asn Asp Val Lys Val Gly Gly
                85                  90                  95      
Ser Lys Tyr Gly Ile Ile Asn Leu Gln Ser Leu Lys Thr Pro Thr Leu
            100                 105                 110         
Lys Val Phe Met His Glu Asn Leu Tyr Phe Thr Asn Arg Lys Val Asn
        115                 120                 125             
Ser Val Cys Trp Ala Ser Leu Asn His Leu Asp Ser His Ile Leu Leu
    130                 135                 140                 
Cys Leu Met Gly Leu Ala Glu Thr Pro Gly Cys Ala Thr Leu Leu Pro
145                 150                 155                 160 
Ala Ser Leu Phe Val Asn Ser His Pro Gly Ile Asp Arg Pro Gly Met
                165                 170                 175     
Leu Cys Ser Phe Arg Ile Pro Gly Ala Trp Ser Cys Ala Trp Ser Leu
            180                 185                 190         
Asn Ile Gln Ala Asn Asn Cys Phe Ser Thr Gly Leu Ser Arg Arg Val
        195                 200                 205             
Leu Leu Thr Asn Val Val Thr Gly His Arg Gln Ser Phe Gly Thr Asn
    210                 215                 220                 
Ser Asp Val Leu Ala Gln Gln Phe Ala Leu Met Ala Pro Leu Leu Phe
225                 230                 235                 240 
Asn Gly Cys Arg Ser Gly Glu Ile Phe Ala Ile Asp Leu Arg Cys Gly
                245                 250                 255     
Asn Gln Gly Lys Gly Trp Lys Ala Thr Arg Leu Phe His Asp Ser Ala
            260                 265                 270         
Val Thr Ser Val Arg Ile Leu Gln Asp Glu Gln Tyr Leu Met Ala Ser
        275                 280                 285             
Asp Met Ala Gly Lys Ile Lys Leu Trp Asp Leu Arg Thr Thr Lys Cys
    290                 295                 300                 
Val Arg Gln Tyr Glu Gly His Val Asn Glu Tyr Ala Tyr Leu Pro Leu
305                 310                 315                 320 
His Val His Glu Glu Glu Gly Ile Leu Val Ala Val Gly Gln Asp Cys
                325                 330                 335     
Tyr Thr Arg Ile Trp Ser Leu His Asp Ala Arg Leu Leu Arg Thr Ile
            340                 345                 350         
Pro Ser Pro Tyr Pro Ala Ser Lys Ala Asp Ile Pro Ser Val Ala Phe
        355                 360                 365             
Ser Ser Arg Leu Gly Gly Ser Arg Gly Ala Pro Gly Leu Leu Met Ala
    370                 375                 380                 
Val Gly Gln Asp Leu Tyr Cys Tyr Ser Tyr Ser
385                 390                 395 


<210> 6224
<211> 497
<212> PRT
<213> Homo sapiens

<400> 6224
Met Asn Lys Ser Arg Trp Gln Ser Arg Arg Arg His Gly Arg Arg Ser
 1               5                  10                  15      
His Gln Gln Asn Pro Trp Phe Arg Leu Arg Asp Ser Glu Asp Arg Gln
            20                  25                  30          
Val Ser Asp Ser Arg Ala Ala Gln Pro Ala His Asp Ser Gly His Gly
        35                  40                  45              
Asp Asp Glu Ser Pro Ser Thr Ser Ser Gly Thr Ala Gly Thr Ser Ser
    50                  55                  60                  
Val Pro Glu Leu Pro Gly Phe Tyr Phe Asp Pro Glu Lys Lys Arg Tyr
65                  70                  75                  80  
Phe Arg Leu Leu Pro Gly His Asn Asn Cys Asn Pro Leu Thr Lys Glu
                85                  90                  95      
Ser Ile Arg Gln Lys Glu Met Glu Ser Lys Arg Leu Arg Leu Leu Gln
            100                 105                 110         
Glu Glu Asp Arg Arg Lys Lys Ile Ala Arg Met Gly Phe Asn Ala Ser
        115                 120                 125             
Ser Met Leu Arg Lys Ser Gln Leu Gly Phe Leu Asn Val Thr Asn Tyr
    130                 135                 140                 
Cys His Leu Ala His Glu Leu Arg Leu Ser Cys Met Glu Arg Lys Lys
145                 150                 155                 160 
Val Gln Ile Arg Ser Met Asp Pro Ser Ala Leu Ala Ser Asp Arg Phe
                165                 170                 175     
Asn Leu Ile Leu Ala Asp Thr Asn Ser Asp Arg Leu Phe Thr Val Asn
            180                 185                 190         
Asp Val Lys Val Gly Gly Ser Lys Tyr Gly Ile Ile Asn Leu Gln Ser
        195                 200                 205             
Leu Lys Thr Pro Thr Leu Lys Val Phe Met His Glu Asn Leu Tyr Phe
    210                 215                 220                 
Thr Asn Arg Lys Val Asn Ser Val Cys Trp Ala Ser Leu Asn His Leu
225                 230                 235                 240 
Asp Ser His Ile Leu Leu Cys Leu Met Gly Leu Ala Glu Thr Pro Gly
                245                 250                 255     
Cys Ala Thr Leu Leu Pro Ala Ser Leu Phe Val Asn Ser His Pro Gly
            260                 265                 270         
Ile Asp Arg Pro Gly Met Leu Cys Ser Phe Arg Ile Pro Gly Ala Trp
        275                 280                 285             
Ser Cys Ala Trp Ser Leu Asn Ile Gln Ala Asn Asn Cys Phe Ser Thr
    290                 295                 300                 
Gly Leu Ser Arg Arg Val Leu Leu Thr Asn Val Val Thr Gly His Arg
305                 310                 315                 320 
Gln Ser Phe Gly Thr Asn Ser Asp Val Leu Ala Gln Gln Phe Ala Leu
                325                 330                 335     
Met Ala Pro Leu Leu Phe Asn Gly Cys Arg Ser Gly Glu Ile Phe Ala
            340                 345                 350         
Ile Asp Leu Arg Cys Gly Asn Gln Gly Lys Gly Trp Lys Ala Thr Arg
        355                 360                 365             
Leu Phe His Asp Ser Ala Val Thr Ser Val Arg Ile Leu Gln Asp Glu
    370                 375                 380                 
Gln Tyr Leu Met Ala Ser Asp Met Ala Gly Lys Ile Lys Leu Trp Asp
385                 390                 395                 400 
Leu Arg Thr Thr Lys Cys Val Arg Gln Tyr Glu Gly His Val Asn Glu
                405                 410                 415     
Tyr Ala Tyr Leu Pro Leu His Val His Glu Glu Glu Gly Ile Leu Val
            420                 425                 430         
Ala Val Gly Gln Asp Cys Tyr Thr Arg Ile Trp Ser Leu His Asp Ala
        435                 440                 445             
Arg Leu Leu Arg Thr Ile Pro Ser Pro Tyr Pro Ala Ser Lys Ala Asp
    450                 455                 460                 
Ile Pro Ser Val Ala Phe Ser Ser Arg Leu Gly Gly Ser Arg Gly Ala
465                 470                 475                 480 
Pro Gly Leu Leu Met Ala Val Gly Gln Asp Leu Tyr Cys Tyr Ser Tyr
                485                 490                 495     
Ser
    


<210> 6225
<211> 202
<212> PRT
<213> Homo sapiens

<400> 6225
Met Ala Lys Ala Tyr Asp His Leu Phe Lys Leu Leu Leu Ile Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Thr Cys Leu Ile Ile Arg Phe Ala Glu Asp Asn
            20                  25                  30          
Phe Asn Asn Thr Tyr Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg
        35                  40                  45              
Thr Val Asp Ile Glu Gly Lys Lys Ile Lys Leu Gln Val Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Phe Lys Thr Ile Thr Thr Ala Tyr Tyr Arg Gly
65                  70                  75                  80  
Ala Met Gly Ile Ile Leu Ala Tyr Asp Ile Thr Asp Glu Lys Ser Phe
                85                  90                  95      
Glu Asn Ile Gln Asn Trp Met Lys Ser Ile Met Glu Asn Ala Ser Ala
            100                 105                 110         
Gly Val Glu His Leu Leu Leu Gly Asn Lys Cys Asp Met Glu Ala Lys
        115                 120                 125             
Arg Lys Val Gln Lys Glu Gln Ala Asp Lys Leu Ala Arg Glu His Gly
    130                 135                 140                 
Ile Arg Phe Phe Glu Thr Ser Ala Lys Ser Ser Met Asn Val Asp Glu
145                 150                 155                 160 
Ala Phe Ser Ser Leu Ala Arg Asp Ile Leu Leu Lys Ser Gly Gly Arg
                165                 170                 175     
Arg Ser Gly Asn Gly Asn Lys Pro Pro Ser Thr Asp Leu Lys Thr Cys
            180                 185                 190         
Asp Ile Lys Asn Thr Asn Lys Cys Ser Leu
        195                 200         


<210> 6226
<211> 217
<212> PRT
<213> Homo sapiens

<400> 6226
Ser Ser Asn Leu Ile His His Gln Arg Ile His Ser Gly Glu Lys Pro
 1               5                  10                  15      
Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Asn Arg Gln Ser Asn Leu
            20                  25                  30          
Ile Gln His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Asp Cys Lys
        35                  40                  45              
Glu Cys Gly Lys Ala Phe Ser Thr Gln Leu Phe Leu Ile Gln His Gln
    50                  55                  60                  
Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Ala Lys
65                  70                  75                  80  
Ser Phe Ser Leu Asn Arg Thr Leu Thr Val His Gln Arg Ile His Thr
                85                  90                  95      
Gly Glu Lys Pro Tyr Arg Cys Asn Glu Cys Gly Lys Ser Phe Ser Gln
            100                 105                 110         
Cys Ser Gln Val Ile Gln His Lys Arg Ile His Thr Gly Glu Lys Pro
        115                 120                 125             
Tyr Ile Cys Asn Asp Asp Cys Gly Lys Ala Phe Ser Gln Ser Ala His
    130                 135                 140                 
Leu Ile His His Gln Arg Ile His Thr Gly Glu Asn Pro Tyr Glu Cys
145                 150                 155                 160 
Ser Glu Cys Gly Lys Ala Phe Asn Val Cys Ser Ser Leu Ile Gln His
                165                 170                 175     
His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Asp Cys Gly
            180                 185                 190         
Lys Ala Phe Ser Gln His Ser Gln Phe Ile Gln His Gln Arg Ile His
        195                 200                 205             
Thr Gly Glu Lys Pro Tyr Met Cys Asn
    210                 215         


<210> 6227
<211> 653
<212> PRT
<213> Homo sapiens

<400> 6227
His Ile Val Val Ser Phe Glu Asp Val Ala Val Pro Leu Ser Gln Glu
 1               5                  10                  15      
Glu Trp Asp Cys Leu Ile Pro Ala Gln Arg Gly Leu Tyr Lys Asp Val
            20                  25                  30          
Met Met Gly Thr Tyr Gly Asn Leu Leu Ser Leu Gly Leu Gln Ala Ser
        35                  40                  45              
Lys Pro Asp Val Ile Ser Arg Leu Glu Arg Gly Asp Glu Pro Pro Ser
    50                  55                  60                  
His Pro Glu Asn Ser Gly Glu Leu Glu Leu Glu Ala Gln Glu Arg Arg
65                  70                  75                  80  
Gln Ser Ser Val Leu Ser Glu Asn Gln Arg Met Asn Asn Pro Glu Arg
                85                  90                  95      
Trp Phe Glu Ser Thr Gly Cys Gly Lys Thr Tyr Asn Gln Asn Arg Ala
            100                 105                 110         
Phe Asn Gln His Gln Arg Phe His Ser Gly Glu Lys Thr Tyr Glu His
        115                 120                 125             
Asn Glu Cys Gly Lys Ala Phe Ser Trp Pro Ser Ile Leu Ser Lys His
    130                 135                 140                 
Gln Arg Ile His Thr Gly Lys Lys Leu Tyr Thr Cys Glu Asp Cys Gly
145                 150                 155                 160 
Lys Ser Phe Ser Val His Ser Tyr Phe Ile Gln His Cys Lys Ile His
                165                 170                 175     
Thr Arg Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys Ala Phe Ser
            180                 185                 190         
Thr His Ser Ser Tyr Val Gln His Leu Lys Ile His Thr Gly Glu Lys
        195                 200                 205             
His His Glu Cys Asn Gln Cys Gly Lys Ala Phe Ser His Ser Ser Asn
    210                 215                 220                 
Leu Ile His His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys
225                 230                 235                 240 
Lys Glu Cys Gly Lys Ala Phe Asn Arg Gln Ser Asn Leu Ile Gln His
                245                 250                 255     
Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Asp Cys Lys Glu Cys Gly
            260                 265                 270         
Lys Ala Phe Ser Thr Gln Leu Phe Leu Ile Gln His Gln Arg Ile His
        275                 280                 285             
Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Ala Lys Ser Phe Ser
    290                 295                 300                 
Leu Asn Arg Thr Leu Thr Val His Gln Arg Ile His Thr Gly Glu Lys
305                 310                 315                 320 
Pro Tyr Arg Cys Asn Glu Cys Gly Lys Ser Phe Ser Gln Cys Ser Gln
                325                 330                 335     
Val Ile Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys
            340                 345                 350         
Asn Asp Glu Cys Gly Lys Ala Phe Arg Arg Ser Ser Asn Leu Ile Lys
        355                 360                 365             
His His Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys Gly Glu Cys
    370                 375                 380                 
Gly Lys Ala Phe Ser Gln Ser Ala His Leu Arg Lys His Gln Arg Val
385                 390                 395                 400 
His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Asp Cys Gly Lys Pro Phe
                405                 410                 415     
Ser Arg Val Ser Asn Leu Ile Lys His His Arg Val His Thr Gly Glu
            420                 425                 430         
Lys Pro Tyr Lys Cys Ser Asp Cys Gly Lys Ala Phe Ser Gln Ser Ser
        435                 440                 445             
Ser Leu Ile Gln His Arg Arg Ile His Thr Gly Glu Lys Pro His Val
    450                 455                 460                 
Cys Asn Val Cys Gly Lys Ala Phe Ser Tyr Ser Ser Val Leu Arg Lys
465                 470                 475                 480 
His Gln Ile Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Ser Val Cys
                485                 490                 495     
Gly Lys Ala Phe Ser His Ser Ser Ala Leu Ile Gln His Gln Gly Val
            500                 505                 510         
His Thr Gly Asp Lys Pro Tyr Ala Cys His Glu Cys Gly Lys Thr Phe
        515                 520                 525             
Gly Arg Ser Ser Asn Leu Ile Leu His Gln Arg Val His Thr Gly Glu
    530                 535                 540                 
Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Thr Phe Ser Gln Ser Ser
545                 550                 555                 560 
Thr Leu Ile Gln His Gln Arg Ile His Asn Gly Leu Lys Pro His Glu
                565                 570                 575     
Cys Asn Gln Cys Gly Lys Ala Phe Asn Arg Ser Ser Asn Leu Ile His
            580                 585                 590         
His Gln Lys Val His Thr Gly Glu Lys Pro Tyr Thr Cys Val Glu Cys
        595                 600                 605             
Gly Lys Gly Phe Ser Gln Ser Ser His Leu Ile Gln His Gln Ile Ile
    610                 615                 620                 
His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe
625                 630                 635                 640 
Ser Gln Arg Ser Val Leu Ile Gln His Gln Arg Ile His
                645                 650             


<210> 6228
<211> 631
<212> PRT
<213> Homo sapiens

<400> 6228
Met Ile Pro Lys Gln Asp Ile Ser Glu Glu Leu Glu Ser Gln Arg Ala
 1               5                  10                  15      
Lys Ser Glu Asp His Val Arg Asn Ile Phe Lys Glu Thr Glu Glu Met
            20                  25                  30          
Ser Lys Thr Glu Gly Lys Leu Glu Asn Cys Trp Arg Lys Tyr Ala Val
        35                  40                  45              
Glu Gly Val Lys Asn Ser Phe Ser Gln Lys Ser Asn Phe Arg Glu Ile
    50                  55                  60                  
Thr Met Arg Tyr Val Lys Thr Leu Ser Arg Glu Asn Gly Gln Lys Phe
65                  70                  75                  80  
Asn Ala Val Gly Glu Asn Cys Ile Thr Asp Ser Asn Pro Ala Lys His
                85                  90                  95      
Leu Arg Gly Ser Arg Glu Glu Ser Leu His Pro Ser Val Ser Ser Val
            100                 105                 110         
Glu Asn Leu Gln Gln His Glu Asp Leu Ile Asn Leu Gln Ser Phe Gln
        115                 120                 125             
Leu Gly Glu Arg Ala Tyr Gln Thr Asp Val Leu Val Lys Val Pro Arg
    130                 135                 140                 
Gln Ser Ser Val Leu Ser Glu Asn Gln Arg Met Asn Asn Pro Glu Arg
145                 150                 155                 160 
Trp Phe Glu Ser Thr Gly Cys Gly Lys Thr Tyr Asn Gln Asn Arg Ala
                165                 170                 175     
Phe Asn Gln His Gln Arg Phe His Ser Gly Glu Lys Thr Tyr Glu His
            180                 185                 190         
Asn Glu Cys Gly Lys Ala Phe Ser Trp Pro Ser Ile Leu Ser Lys His
        195                 200                 205             
Gln Arg Ile His Thr Gly Lys Lys Leu Tyr Thr Cys Glu Asp Cys Gly
    210                 215                 220                 
Lys Ser Phe Ser Val His Ser Tyr Phe Ile Gln His Cys Lys Ile His
225                 230                 235                 240 
Thr Arg Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys Ala Phe Ser
                245                 250                 255     
Thr His Ser Ser Tyr Val Gln His Leu Lys Ile His Thr Gly Glu Lys
            260                 265                 270         
His His Glu Cys Asn Gln Cys Gly Lys Ala Phe Ser His Ser Ser Asn
        275                 280                 285             
Leu Ile His His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys
    290                 295                 300                 
Lys Glu Cys Gly Lys Ala Phe Asn Arg Gln Ser Asn Leu Ile Gln His
305                 310                 315                 320 
Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Asp Cys Lys Glu Cys Gly
                325                 330                 335     
Lys Ala Phe Ser Thr Gln Leu Phe Leu Ile Gln His Gln Arg Ile His
            340                 345                 350         
Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Ala Lys Ser Phe Ser
        355                 360                 365             
Leu Asn Arg Thr Leu Thr Val His Gln Arg Ile His Thr Gly Glu Lys
    370                 375                 380                 
Pro Tyr Arg Cys Asn Glu Cys Gly Lys Ser Phe Ser Gln Cys Ser Gln
385                 390                 395                 400 
Val Ile Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys
                405                 410                 415     
Asn Glu Cys Gly Lys Ser Phe Gly Ala Arg Leu Ser Leu Ile Gln His
            420                 425                 430         
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Gly Cys Ser Arg Ile His
        435                 440                 445             
Asn Gly Asp Lys Pro Tyr Glu Cys His Lys Cys Gly Lys Ala Phe Ser
    450                 455                 460                 
Gln Gly Ser His Leu Ile Gln His Gln Arg Ser His Ile Gly Glu Lys
465                 470                 475                 480 
Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Gly Gln Ile Ser Thr
                485                 490                 495     
Leu Ile Lys His Glu Arg Thr His Asn Gly Glu Lys Pro Tyr Glu Cys
            500                 505                 510         
Ser Asp Cys Gly Lys Ala Phe Ser Gln Ser Ala His Leu Ile His His
        515                 520                 525             
Gln Arg Ile His Thr Gly Glu Asn Pro Tyr Glu Cys Ser Glu Cys Gly
    530                 535                 540                 
Lys Ala Phe Asn Val Cys Ser Ser Leu Ile Gln His His Arg Ile His
545                 550                 555                 560 
Thr Gly Glu Lys Pro Tyr Glu Cys Ser Asp Cys Gly Lys Ala Phe Ser
                565                 570                 575     
Gln His Ser Gln Phe Ile Gln His Gln Arg Ile His Thr Gly Glu Lys
            580                 585                 590         
Pro Tyr Met Cys Asn Glu Cys Glu Lys Ser Phe Ser Ala Cys Leu Ser
        595                 600                 605             
Leu Ile Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys
    610                 615                 620                 
Ala Lys Cys Gly Lys Ser Phe
625                 630     


<210> 6229
<211> 684
<212> PRT
<213> Homo sapiens

<400> 6229
Val Val Ser Phe Glu Asp Val Ala Val Pro Leu Ser Gln Glu Glu Trp
 1               5                  10                  15      
Asp Cys Leu Ile Pro Ala Gln Arg Gly Leu Tyr Lys Asp Val Met Met
            20                  25                  30          
Gly Thr Tyr Gly Asn Leu Leu Ser Leu Gly Cys Asp Ser Arg Ile Glu
        35                  40                  45              
Lys Glu Glu Met Ile Pro Lys Gln Asp Ile Ser Glu Glu Leu Glu Ser
    50                  55                  60                  
Gln Arg Ala Lys Ser Glu Asp His Val Arg Asn Ile Phe Lys Glu Thr
65                  70                  75                  80  
Glu Glu Met Ser Lys Thr Glu Gly Asn Lys His Gln Arg Ile His Thr
                85                  90                  95      
Gly Lys Lys Leu Tyr Thr Cys Glu Asp Cys Gly Lys Ser Phe Ser Val
            100                 105                 110         
His Ser Tyr Phe Ile Gln His Cys Lys Ile His Thr Arg Glu Lys Pro
        115                 120                 125             
Tyr Glu Cys Ile Lys Cys Gly Lys Ala Phe Ser Thr His Ser Ser Tyr
    130                 135                 140                 
Val Gln His Leu Lys Ile His Thr Gly Glu Lys His His Glu Cys Asn
145                 150                 155                 160 
Gln Cys Gly Lys Ala Phe Ser His Ser Ser Asn Leu Ile His His Gln
                165                 170                 175     
Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys
            180                 185                 190         
Ala Phe Asn Arg Gln Ser Asn Leu Ile Gln His Gln Arg Ile His Ser
        195                 200                 205             
Gly Glu Lys Pro Tyr Asp Cys Lys Glu Cys Gly Lys Ala Phe Ser Thr
    210                 215                 220                 
Gln Leu Phe Leu Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro
225                 230                 235                 240 
Tyr Glu Cys Asn Glu Cys Ala Lys Ser Phe Ser Leu Asn Arg Thr Leu
                245                 250                 255     
Thr Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Asn
            260                 265                 270         
Glu Cys Gly Lys Ser Phe Ser Gln Cys Ser Gln Val Ile Gln His Lys
        275                 280                 285             
Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Asn Asp Glu Arg Pro
    290                 295                 300                 
Tyr Met Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Asn Ser Ser Leu
305                 310                 315                 320 
Lys Lys His Gln Lys Ser His Met Ser Glu Lys Pro Tyr Glu Cys Asn
                325                 330                 335     
Glu Cys Gly Lys Ala Phe Arg Arg Ser Ser Asn Leu Ile Gln His Gln
            340                 345                 350         
Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys Ser Glu Cys Gly Lys
        355                 360                 365             
Ala Phe Arg Arg Ser Ser Asn Leu Ile Lys His His Arg Thr His Thr
    370                 375                 380                 
Gly Glu Lys Pro Phe Glu Cys Gly Glu Cys Gly Lys Ala Phe Ser Gln
385                 390                 395                 400 
Ser Ala His Leu Arg Lys His Gln Arg Val His Thr Gly Glu Lys Pro
                405                 410                 415     
Tyr Glu Cys Asn Asp Cys Gly Lys Pro Phe Ser Arg Val Ser Asn Leu
            420                 425                 430         
Ile Lys His His Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Ser
        435                 440                 445             
Asp Cys Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu Ile Gln His Arg
    450                 455                 460                 
Arg Ile His Thr Gly Glu Lys Pro His Val Cys Asn Val Cys Gly Lys
465                 470                 475                 480 
Ala Phe Ser Tyr Ser Ser Val Leu Arg Lys His Gln Ile Ile His Thr
                485                 490                 495     
Gly Glu Lys Pro Tyr Arg Cys Ser Val Cys Gly Lys Ala Phe Ser His
            500                 505                 510         
Ser Ser Ala Leu Ile Gln His Gln Gly Val His Thr Gly Asp Lys Pro
        515                 520                 525             
Tyr Ala Cys His Glu Cys Gly Lys Thr Phe Gly Arg Ser Ser Asn Leu
    530                 535                 540                 
Ile Leu His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Thr
545                 550                 555                 560 
Glu Cys Gly Lys Thr Phe Ser Gln Ser Ser Thr Leu Ile Gln His Gln
                565                 570                 575     
Arg Ile His Asn Gly Leu Lys Pro His Glu Cys Asn Gln Cys Gly Lys
            580                 585                 590         
Ala Phe Asn Arg Ser Ser Asn Leu Ile His His Gln Lys Val His Thr
        595                 600                 605             
Gly Glu Lys Pro Tyr Thr Cys Val Glu Cys Gly Lys Gly Phe Ser Gln
    610                 615                 620                 
Ser Ser His Leu Ile Gln His Gln Ile Ile His Thr Gly Glu Arg Pro
625                 630                 635                 640 
Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Arg Ser Val Leu
                645                 650                 655     
Ile Gln His Gln Arg Ile His Thr Gly Val Lys Pro Tyr Asp Cys Ala
            660                 665                 670         
Ala Cys Gly Lys Ala Phe Ser Gln Arg Ser Lys Leu
        675                 680                 


<210> 6230
<211> 434
<212> PRT
<213> Homo sapiens

<400> 6230
Met Lys Arg Asn Ser Leu Ser Val Glu Asn Lys Ile Val Gln Leu Ser
 1               5                  10                  15      
Gly Ala Ala Lys Gln Pro Lys Val Gly Phe Tyr Ser Ser Leu Asn Gln
            20                  25                  30          
Thr His Thr His Thr Val Leu Leu Asp Trp Gly Ser Leu Pro His His
        35                  40                  45              
Val Val Leu Gln Ile Phe Gln Tyr Leu Pro Leu Leu Asp Arg Ala Cys
    50                  55                  60                  
Ala Ser Ser Val Cys Arg Arg Trp Asn Glu Val Phe His Ile Ser Asp
65                  70                  75                  80  
Leu Trp Arg Lys Phe Glu Phe Glu Leu Asn Gln Ser Ala Thr Ser Ser
                85                  90                  95      
Phe Lys Ser Thr His Pro Asp Leu Ile Gln Gln Ile Ile Lys Lys His
            100                 105                 110         
Phe Ala His Leu Gln Tyr Val Ser Phe Lys Val Asp Ser Ser Ala Glu
        115                 120                 125             
Ser Ala Glu Ala Ala Cys Asp Ile Leu Ser Gln Leu Val Asn Cys Ser
    130                 135                 140                 
Ile Gln Thr Leu Gly Leu Ile Ser Thr Ala Lys Pro Ser Phe Met Asn
145                 150                 155                 160 
Val Ser Glu Ser His Phe Val Ser Ala Leu Thr Val Val Phe Ile Asn
                165                 170                 175     
Ser Lys Ser Leu Ser Ser Ile Lys Ile Glu Asp Thr Pro Val Asp Asp
            180                 185                 190         
Pro Ser Leu Lys Ile Leu Val Ala Asn Asn Ser Asp Thr Leu Arg Leu
        195                 200                 205             
Pro Lys Met Ser Ser Cys Pro His Val Ser Ser Asp Gly Ile Leu Cys
    210                 215                 220                 
Val Ala Asp Arg Cys Gln Gly Leu Arg Glu Leu Ala Leu Asn Tyr Tyr
225                 230                 235                 240 
Ile Leu Thr Asp Glu Leu Phe Leu Ala Leu Ser Ser Glu Thr His Val
                245                 250                 255     
Asn Leu Glu His Leu Arg Ile Asp Val Val Ser Glu Asn Pro Gly Gln
            260                 265                 270         
Ile Lys Phe His Ala Val Lys Lys His Ser Trp Asp Ala Leu Ile Lys
        275                 280                 285             
His Ser Pro Arg Val Asn Val Val Met His Phe Phe Leu Tyr Glu Glu
    290                 295                 300                 
Glu Phe Glu Thr Phe Phe Lys Glu Glu Thr Pro Val Thr His Leu Tyr
305                 310                 315                 320 
Phe Gly Arg Ser Val Ser Lys Val Val Leu Gly Arg Val Gly Leu Asn
                325                 330                 335     
Cys Pro Arg Leu Ile Glu Leu Val Val Cys Ala Asn Asp Leu Gln Pro
            340                 345                 350         
Leu Asp Asn Glu Leu Ile Cys Ile Ala Glu His Cys Thr Asn Leu Thr
        355                 360                 365             
Ala Leu Gly Leu Ser Lys Cys Glu Val Ser Cys Ser Ala Phe Ile Arg
    370                 375                 380                 
Phe Val Arg Leu Cys Glu Arg Arg Leu Thr Gln Leu Ser Val Met Glu
385                 390                 395                 400 
Glu Val Leu Ile Pro Asp Glu Asp Tyr Ser Leu Asp Glu Ile His Thr
                405                 410                 415     
Glu Val Ser Lys Tyr Leu Gly Arg Val Trp Phe Pro Asp Val Met Pro
            420                 425                 430         
Leu Trp
        


<210> 6231
<211> 462
<212> PRT
<213> Homo sapiens

<400> 6231
Glu Gly Lys Gly Pro Ala Pro Ser Ala Arg Pro Glu Ser Gly Pro Arg
 1               5                  10                  15      
Gly Gly Cys Ala Ser Arg Pro Arg Pro Leu Arg Pro Gly Ser Glu Gln
            20                  25                  30          
Gln Gln Glu Glu Arg Gln Arg Pro Gly Val Gly Arg Gly Trp Gly Gly
        35                  40                  45              
Gly Thr Gly Arg Arg Glu Gly Ala Gly Ala Gly Arg Gly Pro Arg Arg
    50                  55                  60                  
Ile Lys Met Ala Met Ser Leu Ile Gln Ala Cys Cys Ser Leu Ala Leu
65                  70                  75                  80  
Ser Thr Trp Leu Leu Ser Phe Cys Phe Val His Leu Leu Cys Leu Asp
                85                  90                  95      
Phe Thr Val Ala Glu Lys Glu Glu Trp Tyr Thr Ala Phe Val Asn Ile
            100                 105                 110         
Thr Tyr Ala Glu Pro Ala Pro Asp Pro Gly Ala Gly Ala Ala Gly Gly
        115                 120                 125             
Gly Gly Ala Glu Leu His Thr Glu Lys Thr Glu Cys Gly Arg Tyr Gly
    130                 135                 140                 
Glu His Ser Pro Lys Gln Asp Ala Arg Gly Glu Val Val Met Ala Ser
145                 150                 155                 160 
Ser Ala His Asp Arg Leu Ala Cys Asp Pro Asn Thr Lys Phe Ala Ala
                165                 170                 175     
Pro Thr Arg Gly Lys Asn Trp Ile Ala Leu Ile Pro Lys Gly Asn Cys
            180                 185                 190         
Thr Tyr Arg Asp Lys Ile Arg Asn Ala Phe Leu Gln Asn Ala Ser Ala
        195                 200                 205             
Val Val Ile Phe Asn Val Gly Ser Asn Thr Asn Glu Thr Ile Thr Met
    210                 215                 220                 
Pro His Ala Gly Val Glu Asp Ile Val Ala Ile Met Ile Pro Glu Pro
225                 230                 235                 240 
Lys Gly Lys Glu Ile Val Ser Leu Leu Glu Arg Asn Ile Thr Val Thr
                245                 250                 255     
Met Tyr Ile Thr Ile Gly Thr Arg Asn Leu Gln Lys Tyr Arg Arg Leu
            260                 265                 270         
Gly Asp Ala Ala Lys Lys Ala Ile Ser Lys Leu Gln Ile Arg Thr Ile
        275                 280                 285             
Lys Lys Gly Asp Lys Glu Thr Glu Ser Asp Phe Asp Asn Cys Ala Val
    290                 295                 300                 
Cys Ile Glu Gly Tyr Lys Pro Asn Asp Val Val Arg Ile Leu Pro Cys
305                 310                 315                 320 
Arg His Leu Phe His Lys Ser Cys Val Asp Pro Trp Leu Leu Asp His
                325                 330                 335     
Arg Thr Cys Pro Met Cys Lys Met Asn Ile Leu Lys Ala Leu Gly Ile
            340                 345                 350         
Pro Pro Asn Ala Asp Cys Met Asp Asp Leu Pro Thr Asp Phe Glu Gly
        355                 360                 365             
Ser Leu Gly Gly Pro Pro Thr Asn Gln Ile Thr Gly Ala Ser Asp Thr
    370                 375                 380                 
Thr Val Asn Glu Ser Ser Val Thr Leu Asp Pro Ala Val Arg Thr Val
385                 390                 395                 400 
Gly Ala Leu Gln Val Val Gln Asp Thr Asp Pro Ile Pro Gln Glu Gly
                405                 410                 415     
Asp Val Ile Phe Thr Thr Asn Ser Glu Gln Glu Pro Ala Val Ser Ser
            420                 425                 430         
Asp Ser Asp Ile Ser Leu Ile Met Ala Met Glu Val Gly Leu Ser Asp
        435                 440                 445             
Val Glu Leu Ser Thr Asp Gln Asp Cys Glu Glu Val Lys Ser
    450                 455                 460         


<210> 6232
<211> 420
<212> PRT
<213> Homo sapiens

<400> 6232
Met Leu Arg Ser Gln Pro Arg Ala Leu Glu Lys Arg Glu Ser Thr Asp
 1               5                  10                  15      
Val Arg Thr Glu Ala Arg Gly Asp Leu Ser Cys Arg Pro Leu Asp Phe
            20                  25                  30          
Val Gly Thr Phe Ser Asn Arg Trp Ser Tyr Gly Ile Thr Phe Gly Ala
        35                  40                  45              
Thr Ala Asn Lys Val Met Phe Leu Phe Ser Glu Gly Tyr Gln Pro Leu
    50                  55                  60                  
Gln Ile Pro Gln Trp Ala Gln Ala Phe Glu Leu Leu Ile Gly Gly Ile
65                  70                  75                  80  
Glu Val Gly Leu Ser His Phe Pro Phe Phe Ala Cys Leu Ser Ser Glu
                85                  90                  95      
Phe Gln Leu Val Ser Ser Ile Leu Gly Phe Cys Tyr Ser Asp Leu Gly
            100                 105                 110         
Asp Arg Leu Gly Arg Asp Val His Gly Gly Pro Gly Ile Ser Pro Pro
        115                 120                 125             
Lys Gly Asp Arg Phe Ala Val Thr Ile Ile Gln Val Ser Gln Cys Pro
    130                 135                 140                 
His Gly Gln Ala Arg Arg Arg Pro Ala Gly Ala Thr Glu Asp Glu Val
145                 150                 155                 160 
Ala Arg Ser Ala Lys Lys Met Asp Glu Ile Val Gln Glu Lys Asn Thr
                165                 170                 175     
Ala Gly Ala Leu Gly Leu Leu Thr Glu Leu Gln Asn Val Leu Glu Leu
            180                 185                 190         
Leu Arg Ser Thr Gly Thr Gly Met Leu Leu Asn Val Ser Leu Lys Gln
        195                 200                 205             
Ser Thr Asp Glu Glu Val Thr Ser Leu Ala Lys Ser Phe Val Lys Ser
    210                 215                 220                 
Trp Lys Thr Leu Pro Asp Glu Pro Ser Thr Glu Lys Asp Pro Asn Glu
225                 230                 235                 240 
Lys Arg Ile Glu Pro Ala Met Thr Ser Gln Asn Ser Lys Arg Asn Ala
                245                 250                 255     
Ser Asn Ser Val Arg Met Lys Tyr Arg Glu Met Leu Ala Ala Ala Leu
            260                 265                 270         
Arg Thr Gly Asp Asp Cys Ile Glu Met Gly Ala Asp Glu Glu Glu Leu
        275                 280                 285             
Gly Ser Arg Ile Glu Glu Ala Val Asp Pro Glu Arg Gly Asn Thr Gly
    290                 295                 300                 
Met Lys Tyr Lys Asn Arg Val Gln Ser Lys Ile Ser Asn Leu Thr Asp
305                 310                 315                 320 
Ala Lys Asn Pro Asn Leu Arg Lys Asn Ala Ser Cys Gly Asn Ile Pro
                325                 330                 335     
Pro Asp Leu Leu Ala Arg Met Ser Ala Glu Glu Met Ala Ser Asp Glu
            340                 345                 350         
Leu Lys Glu Met His Lys Asn Leu Thr Lys Glu Ala Ile Arg Glu His
        355                 360                 365             
Gln Met Ala Lys Thr Gly Gly Thr Gln Pro Asp Ser Leu Thr Cys Gly
    370                 375                 380                 
Lys Cys Lys Lys Asn Cys Thr Ser Thr Gln Val Gln Ala Cys Ser Val
385                 390                 395                 400 
Gly Glu Pro Met Ala Thr Phe Val Asp Cys Asn Glu Cys Gly Asn Gln
                405                 410                 415     
Gln Lys Phe Cys
            420 


<210> 6233
<211> 1249
<212> PRT
<213> Homo sapiens

<400> 6233
Gln Met Ile Pro Ser Asn Ser Thr Arg Leu Pro Val Ala Tyr Gln Gly
 1               5                  10                  15      
Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu Gln Gln Val Asp Trp Thr
            20                  25                  30          
Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr Pro Asp Tyr Arg Pro Pro
        35                  40                  45              
Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser Phe Leu Pro Asp Ser Thr
    50                  55                  60                  
Ile Gln Lys Gln Asn Phe Ile Pro His Thr Ser Leu Gln Val Lys Asn
65                  70                  75                  80  
Ser Gln Leu Pro Asn Ser Val Leu Thr Leu Pro Ser Arg Gln Thr Ser
                85                  90                  95      
Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln Thr Asp Lys Arg Pro Pro
            100                 105                 110         
Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser Gln Pro Leu Gln Ser Thr
        115                 120                 125             
Gln His Ile Thr Lys His Leu Ser Met Glu Val Pro Gln Ser Gln Glu
    130                 135                 140                 
Met Leu Ser Ser Glu Ile Arg Thr Ser Phe Gln Gln Gln Trp Gln Asn
145                 150                 155                 160 
Pro Asn Glu Asn Val Ser Thr Ile Gly Asn Phe Thr Asn Leu Lys Val
                165                 170                 175     
Asn Thr Asn Ser Lys Gln Pro Phe Asn Gly Pro Ile Arg Ser Ser Val
            180                 185                 190         
Asp Gly Val Gln Thr Leu Ala Gln Thr Asn Glu Glu Lys Ile Met Asp
        195                 200                 205             
Ser Cys Asn Pro Thr Ser Asn Gln Val Leu Asp Thr Ser Val Ala Lys
    210                 215                 220                 
Glu Lys Leu Val Arg Asp Ile Lys Thr Leu Val Glu Ile Lys Gln Lys
225                 230                 235                 240 
Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile Asn Lys Asp Leu Leu Met
                245                 250                 255     
Ala Ala Gly Cys Ile Lys Met Thr Asn Thr Ser Tyr Ser Glu Pro Ala
            260                 265                 270         
Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr Ala Lys Ile Gln Ser Gly
        275                 280                 285             
Pro Gln Ile Thr Pro Val Met Pro Glu Asn Ala Glu Arg Gln Thr Pro
    290                 295                 300                 
Thr Val Val Glu Ser Ala Glu Thr Asn Lys Thr Gln Cys Met Leu Asn
305                 310                 315                 320 
Ser Asp Ile Gln Glu Val Asn Cys Arg Arg Phe Asn Gln Val Asp Ser
                325                 330                 335     
Val Leu Pro Asn Pro Val Tyr Ser Glu Lys Arg Pro Met Pro Asp Pro
            340                 345                 350         
Ser His Asp Val Lys Val Leu Thr Ser Lys Thr Ser Ala Val Glu Met
        355                 360                 365             
Thr Gln Ala Val Leu Asn Thr Gln Leu Ser Ser Glu Asn Val Thr Lys
    370                 375                 380                 
Val Glu Gln Asn Ser Pro Ala Val Cys Glu Thr Ile Ser Val Pro Lys
385                 390                 395                 400 
Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys Ile Gln Asn Glu Asn Met
                405                 410                 415     
Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg Lys Thr Gln Lys Thr Val
            420                 425                 430         
Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp Ser Lys Pro Asp Ser Cys
        435                 440                 445             
Glu Met Asn Pro Asn Thr Gln Met Thr Gly Asn Gln Leu Asn Leu Lys
    450                 455                 460                 
Asn Met Glu Thr Pro Ser Thr Ser Asn Val Ser Gly Arg Val Leu Asp
465                 470                 475                 480 
Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser Thr Lys Gly Met Pro Ala
                485                 490                 495     
Lys Ser Asp Ser Ser Cys Ser Met Glu Val Leu Ala Thr Cys Leu Ser
            500                 505                 510         
Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala Lys Glu Lys Glu Cys Asp
        515                 520                 525             
Lys Leu Arg Thr Asn Thr Thr Ala Val Gly Ile Ser Lys Pro Ala Asn
    530                 535                 540                 
Ile His Val Lys Ser Pro Cys Ser Val Val Gly Asn Ser Asn Ser Gln
545                 550                 555                 560 
Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr Ala Leu Ser Met Val Met
                565                 570                 575     
His Asn Tyr Glu Ser Ser Gly Ile Asn Ile Thr Lys Gly Thr Glu Leu
            580                 585                 590         
Gln Ile Ala Val Val Ser Pro Leu Val Leu Ser Glu Val Lys Thr Leu
        595                 600                 605             
Ser Val Lys Gly Ile Thr Pro Ala Val Leu Pro Glu Thr Val Tyr Pro
    610                 615                 620                 
Val Ile Lys Glu Gly Ser Val Cys Ser Leu Gln Asn Gln Leu Ala Glu
625                 630                 635                 640 
Asn Ala Lys Ala Thr Ala Ala Leu Lys Val Asp Val Ser Gly Pro Val
                645                 650                 655     
Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe Pro Leu Thr Gln Lys Glu
            660                 665                 670         
Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser Glu Val Thr Pro Asn Val
        675                 680                 685             
Asn Gln Gly Lys His Asn Lys Leu Glu Ser Ala Ile His Ser Pro Met
    690                 695                 700                 
Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg Asn Ser Thr Val Val Ser
705                 710                 715                 720 
Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys Ser Leu Val Glu Gly Asp
                725                 730                 735     
Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile Phe Ser Ser Leu Pro Leu
            740                 745                 750         
Lys Met Val Glu Pro Gln Lys Pro Ser Leu Pro Asn Gln Gln Gly Ile
        755                 760                 765             
Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp Asn Thr Thr Glu Asn Lys
    770                 775                 780                 
Asp Phe Gly Phe Gln Lys Asp Lys Pro Val Gln Cys Thr Asp Val Ser
785                 790                 795                 800 
His Lys Ile Cys Asp Gln Ser Lys Ser Glu Pro Pro Leu Glu Ser Ser
                805                 810                 815     
Phe Asn Asn Leu Glu Thr Asn Arg Val Ile Leu Glu Lys Ser Ser Leu
            820                 825                 830         
Glu His Ala Thr Glu Lys Ser Thr Ala Asn Asp Thr Cys Ser Ser Ala
        835                 840                 845             
Ala Ile Gln Glu Asp Ile Tyr Pro Gln Glu Ile Asp Ala Ser Ser Asn
    850                 855                 860                 
Tyr Thr Pro Gln Asp Pro Ala Arg Asn Glu Ile His Ser Asp Lys Ala
865                 870                 875                 880 
Pro Val Leu Tyr Leu His Asp Gln Leu Ser Glu Leu Leu Lys Glu Phe
                885                 890                 895     
Pro Tyr Gly Ile Glu Ala Val Asn Thr Arg Glu Gly Ser Val Gly Gln
            900                 905                 910         
Gln Thr Thr Tyr Gln Thr Ser Glu Asp Gln Thr Ala Asp Lys Thr Ser
        915                 920                 925             
Ser Asp Ser Lys Asp Pro Ala Asp Gln Ile Gln Ile Thr Ile Leu Ser
    930                 935                 940                 
Ser Glu Gln Met Lys Glu Ile Phe Pro Glu Gln Asp Asp Gln Pro Tyr
945                 950                 955                 960 
Val Val Asp Lys Leu Ala Glu Pro Gln Lys Glu Glu Pro Ile Thr Glu
                965                 970                 975     
Val Val Ser Gln Cys Asp Leu Gln Ala Pro Ala Ala Gly Gln Ser Arg
            980                 985                 990         
Asp Ser Val Ile Leu Asp Ser Glu Lys Asp Asp Ile His Cys Cys Ala
        995                 1000                1005            
Leu Gly Trp Leu Ser Met Val Tyr Glu Gly Val Pro Gln Cys Gln Cys
    1010                1015                1020                
Asn Ser Ile Lys Asn Ser Ser Ser Glu Glu Glu Lys Gln Lys Glu Gln
1025                1030                1035                1040
Cys Ser Pro Leu Asp Thr Asn Ser Cys Lys Gln Gly Glu Arg Thr Ser
                1045                1050                1055    
Asp Arg Asp Val Thr Val Val Gln Phe Lys Ser Leu Val Asn Asn Pro
            1060                1065                1070        
Lys Thr Pro Pro Asp Gly Lys Ser His Phe Pro Glu Leu Gln Asp Asp
        1075                1080                1085            
Ser Arg Lys Asp Thr Pro Lys Thr Lys His Lys Ser Leu Pro Arg Thr
    1090                1095                1100                
Glu Gln Glu Leu Val Ala Gly Gln Phe Ser Ser Lys Cys Asp Lys Leu
1105                1110                1115                1120
Asn Pro Leu Gln Asn His Lys Arg Lys Lys Leu Arg Phe His Glu Val
                1125                1130                1135    
Thr Phe His Ser Ser Asn Lys Met Thr Ala Ser Tyr Glu Gln Ala Ser
            1140                1145                1150        
Gln Glu Thr Arg Gln Lys Lys His Val Thr Gln Asn Ser Arg Pro Leu
        1155                1160                1165            
Lys Thr Lys Thr Ala Phe Leu Pro Asn Lys Asp Val Tyr Lys Lys His
    1170                1175                1180                
Ser Ser Leu Gly Gln Ser Leu Ser Pro Glu Lys Ile Lys Leu Lys Leu
1185                1190                1195                1200
Lys Ser Val Ser Phe Lys Gln Lys Arg Lys Leu Asp Gln Gly Asn Val
                1205                1210                1215    
Leu Asp Met Glu Val Lys Lys Lys Lys His Asp Thr Gln Asp Ala Glu
            1220                1225                1230        
Lys Asn Asp Leu Ala Ser Lys Gly His Ser Pro His Pro Gln Arg Leu
        1235                1240                1245            
Lys
    


<210> 6234
<211> 343
<212> PRT
<213> Homo sapiens

<400> 6234
Met Asn Lys Glu Ile Lys Lys Phe Asp Ile Ala Val Leu Gly Ala Gly
 1               5                  10                  15      
Pro Gly Gly Tyr Ser Leu Ala Leu Leu Leu Val Lys Asn Asn Lys Lys
            20                  25                  30          
Val Val Leu Phe Glu Arg Gln Asp Leu Gly Gly Thr Cys Val Asn Glu
        35                  40                  45              
Gly Cys Ile Pro Thr Lys Thr Leu Ile Lys Ser Ala Arg Val Phe Glu
    50                  55                  60                  
Glu Val Lys Arg Ser Ser Gln Phe Gly Val His Thr His Lys Val His
65                  70                  75                  80  
Phe Asn Phe Phe Glu Ile Gln Ala Arg Arg Lys Lys Asn Lys Glu Lys
                85                  90                  95      
Leu Asn Asn Ala Ile Leu Asn Gly Leu Thr Asn Ala Gly Val Glu Val
            100                 105                 110         
Val Phe Gly Glu Ala Thr Ile Leu Asp Gln Asn Asn Ala Arg Val Asn
        115                 120                 125             
Glu Glu Asp Tyr Thr Phe Asp Lys Leu Val Leu Ser Ser Gly Ser Ser
    130                 135                 140                 
Ser Arg Lys Ile Asn Ile Glu Gly Gln Glu Leu Val Glu Asn Glu Gly
145                 150                 155                 160 
Arg Leu Leu Tyr Ser Thr Asp Leu Leu Asn Ile Asn Lys Ala Pro Lys
                165                 170                 175     
Lys Leu Val Ile Ile Gly Ala Gly Pro Ile Ser Leu Glu Phe Ala Tyr
            180                 185                 190         
Leu Phe Ser Ala Leu Gly Ser Glu Val Ser Ile Val Glu Ser Arg Glu
        195                 200                 205             
Phe Leu Gly Asn Phe Asp Thr Lys Leu Gln Ser Asn Val Lys Glu Tyr
    210                 215                 220                 
Leu Gln Gln Arg Asn Ile Lys Ile Tyr Glu Asn Ser Lys Val Val Lys
225                 230                 235                 240 
Phe Thr Asp Ala Asn Thr Val Leu Ile Glu Asn Glu Glu Gln Met Thr
                245                 250                 255     
Leu Gly Phe Cys Arg Val Leu Ile Ala Val Gly Arg Val Ala Asn Thr
            260                 265                 270         
Glu Ser Phe Lys Asn Leu Asn Leu Glu Leu Asn Pro Asn Gln Ser Val
        275                 280                 285             
Lys Val Asp His Arg Asn Lys Thr Ser Leu Glu Asn Val Tyr Ala Ile
    290                 295                 300                 
Gly Asp Val Thr Gly Ser Met Met Leu Ser Ser Ile Ala Tyr Lys Gln
305                 310                 315                 320 
Gly Asp Ile Val Ala Lys Asp Ile Leu Glu Phe Glu Asn Glu Glu Thr
                325                 330                 335     
Leu Asp Val Ser Thr Thr Pro
            340             


<210> 6235
<211> 165
<212> PRT
<213> Homo sapiens

<400> 6235
Met Pro Pro Lys Phe Asp Pro Asn Glu Ile Lys Val Val Tyr Leu Arg
 1               5                  10                  15      
Cys Thr Gly Gly Glu Val Gly Ala Thr Ser Ala Leu Ala Pro Lys Ile
            20                  25                  30          
Gly Pro Leu Gly Leu Ser Pro Lys Lys Val Gly Asp Asp Ile Ala Lys
        35                  40                  45              
Ala Thr Gly Asp Trp Lys Gly Leu Arg Ile Thr Val Lys Leu Thr Ile
    50                  55                  60                  
Gln Asn Arg Gln Ala Gln Ile Glu Val Val Pro Ser Ala Ser Ala Leu
65                  70                  75                  80  
Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg Asp Arg Lys Lys Gln Lys
                85                  90                  95      
Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn Ile
            100                 105                 110         
Ala Arg Gln Met Arg His Arg Ser Leu Ala Arg Glu Leu Ser Gly Thr
        115                 120                 125             
Ile Lys Glu Ile Leu Gly Thr Ala Gln Ser Val Gly Cys Asn Val Asp
    130                 135                 140                 
Gly Arg His Pro His Asp Ile Ile Asp Asp Ile Asn Ser Gly Ala Val
145                 150                 155                 160 
Glu Cys Pro Ala Ser
                165 


<210> 6236
<211> 165
<212> PRT
<213> Homo sapiens

<400> 6236
Met Leu Pro Lys Phe Asp Pro Asn Glu Ile Lys Val Val Tyr Leu Arg
 1               5                  10                  15      
Cys Thr Gly Gly Glu Val Gly Ala Thr Ser Ala Leu Ala Pro Lys Ile
            20                  25                  30          
Gly Pro Leu Gly Leu Ser Pro Lys Lys Val Gly Asp Asp Ile Ala Lys
        35                  40                  45              
Ala Met Gly Asp Trp Lys Gly Leu Arg Ile Thr Val Lys Leu Thr Ile
    50                  55                  60                  
Gln Asn Arg Gln Ala Gln Ile Glu Val Val Pro Ser Ala Ser Ala Met
65                  70                  75                  80  
Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg Asp Arg Lys Lys Gln Lys
                85                  90                  95      
Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn Ile
            100                 105                 110         
Ala Arg Gln Met Arg His Gln Ser Leu Ala Arg Glu Leu Ser Gly Thr
        115                 120                 125             
Thr Lys Glu Ile Leu Gly Thr Ala Gln Ser Val Gly Cys Asn Val Asp
    130                 135                 140                 
Gly Arg His Pro His Asp Ile Ile Asp Asp Ile Asn Ser Gly Ala Val
145                 150                 155                 160 
Glu Cys Pro Ala Ser
                165 


<210> 6237
<211> 166
<212> PRT
<213> Homo sapiens

<400> 6237
Met Pro Pro Lys Phe Asp Pro Asn Glu Ile Lys Val Val Tyr Leu Arg
 1               5                  10                  15      
Cys Thr Gly Gly Glu Val Gly Ala Thr Ser Ala Leu Ala Pro Lys Ile
            20                  25                  30          
Gly Pro Leu Gly Leu Ser Pro Lys Lys Val Gly Asp Asp Ile Ala Lys
        35                  40                  45              
Ala Thr Gly Asp Trp Lys Gly Leu Arg Ile Thr Val Lys Leu Thr Ile
    50                  55                  60                  
Gln Asn Arg Gln Ala Gln Ile Glu Val Val Pro Ser Ala Ser Ala Leu
65                  70                  75                  80  
Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg Asp Arg Lys Lys Gln Lys
                85                  90                  95      
Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn Ile
            100                 105                 110         
Ala Arg Gln Met Arg His Arg Ser Leu Ala Arg Glu Leu Ser Gly Thr
        115                 120                 125             
Ile Lys Glu Ile Leu Gly Thr Ala Gln Ser Val Gly Cys Asn Val Asp
    130                 135                 140                 
Gly Arg His Pro His Asp Ile Ile Asp Asp Ile Asn Ser Gly Ala Val
145                 150                 155                 160 
Glu Cys Pro Ala Val Ser
                165     


<210> 6238
<211> 166
<212> PRT
<213> Homo sapiens

<400> 6238
Met Ala Pro Lys Lys Ala Lys Lys Arg Ala Gly Gly Ala Asn Ser Asn
 1               5                  10                  15      
Val Phe Ser Met Phe Glu Gln Thr Gln Ile Gln Glu Phe Lys Glu Ala
            20                  25                  30          
Phe Thr Ile Met Asp Gln Asn Arg Asp Gly Phe Ile Asp Lys Asn Asp
        35                  40                  45              
Leu Arg Asp Thr Phe Ala Ala Leu Gly Arg Val Asn Val Lys Asn Glu
    50                  55                  60                  
Glu Ile Asp Glu Met Ile Lys Glu Ala Pro Gly Pro Ile Asn Phe Thr
65                  70                  75                  80  
Val Phe Leu Ser Met Phe Gly Glu Lys Leu Lys Gly Ala Asp Pro Glu
                85                  90                  95      
Glu Thr Ile Leu Asn Ala Phe Lys Val Phe Asp Pro Glu Gly Lys Gly
            100                 105                 110         
Val Leu Lys Ala Asp Tyr Val Arg Glu Met Leu Thr Thr Gln Ala Glu
        115                 120                 125             
Arg Phe Ser Lys Glu Glu Val Asp Gln Met Phe Ala Ala Phe Pro Pro
    130                 135                 140                 
Asp Val Thr Gly Asn Leu Asp Tyr Lys Asn Leu Val His Ile Ile Thr
145                 150                 155                 160 
His Gly Glu Glu Lys Asp
                165     


<210> 6239
<211> 431
<212> PRT
<213> Homo sapiens

<400> 6239
Met Gln Lys Ala Thr Tyr Tyr Asp Asn Ala Ala Ala Ala Leu Phe Gly
 1               5                  10                  15      
Gly Tyr Ser Ser Tyr Pro Gly Ser Asn Gly Phe Gly Phe Asp Val Pro
            20                  25                  30          
Pro Gln Pro Pro Phe Gln Ala Ala Thr His Leu Glu Gly Asp Tyr Gln
        35                  40                  45              
Arg Ser Ala Cys Ser Leu Gln Ser Leu Gly Asn Ala Ala Pro His Ala
    50                  55                  60                  
Lys Ser Lys Glu Leu Asn Gly Ser Cys Met Arg Pro Gly Leu Ala Pro
65                  70                  75                  80  
Glu Thr Leu Ser Ala Pro Pro Gly Ser Pro Pro Pro Ser Ala Ala Pro
                85                  90                  95      
Thr Ser Ala Thr Ser Asn Ser Ser Asn Gly Gly Gly Pro Ser Lys Ser
            100                 105                 110         
Gly Pro Pro Lys Cys Gly Pro Gly Thr Asn Ser Thr Leu Thr Lys Gln
        115                 120                 125             
Ile Phe Pro Trp Met Lys Glu Ser Arg Gln Thr Ser Lys Leu Lys Asn
    130                 135                 140                 
Asn Ser Pro Gly Thr Ala Glu Gly Cys Gly Gly Gly Gly Gly Gly Gly
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly
                165                 170                 175     
Gly Gly Asp Lys Ser Pro Pro Gly Ser Ala Ala Ser Lys Arg Ala Arg
            180                 185                 190         
Thr Ala Tyr Thr Ser Ala Gln Leu Val Glu Leu Glu Lys Glu Phe His
        195                 200                 205             
Phe Asn Arg Tyr Leu Cys Arg Pro Arg Arg Val Glu Met Ala Asn Leu
    210                 215                 220                 
Leu Asn Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg
225                 230                 235                 240 
Met Lys Tyr Lys Lys Asp Gln Lys Ala Lys Gly Leu Ala Ser Ser Ser
                245                 250                 255     
Gly Gly Pro Ser Pro Ala Gly Ser Pro Pro Gln Pro Met Gln Ser Thr
            260                 265                 270         
Ala Gly Phe Met Asn Ala Leu His Ser Met Thr Pro Ser Tyr Glu Ser
        275                 280                 285             
Pro Ser Pro Pro Ala Phe Gly Lys Ala His Gln Asn Ala Tyr Ala Leu
    290                 295                 300                 
Pro Ser Asn Tyr Gln Pro Pro Leu Lys Gly Cys Gly Ala Pro Gln Lys
305                 310                 315                 320 
Tyr Pro Pro Thr Pro Ala Pro Glu Tyr Glu Pro His Val Leu Gln Ala
                325                 330                 335     
Asn Gly Gly Ala Tyr Gly Thr Pro Thr Met Gln Gly Ser Pro Val Tyr
            340                 345                 350         
Val Gly Gly Gly Gly Tyr Ala Asp Pro Leu Pro Pro Pro Ala Gly Pro
        355                 360                 365             
Ser Leu Tyr Gly Leu Asn His Leu Ser His His Pro Ser Gly Asn Leu
    370                 375                 380                 
Asp Tyr Asn Gly Ala Pro Pro Met Ala Pro Ser Gln His His Gly Pro
385                 390                 395                 400 
Cys Glu Pro His Pro Thr Tyr Thr Asp Leu Ser Ser His His Ala Pro
                405                 410                 415     
Pro Pro Gln Gly Arg Ile Gln Glu Ala Pro Lys Leu Thr His Leu
            420                 425                 430     


<210> 6240
<211> 204
<212> PRT
<213> Homo sapiens

<400> 6240
Met Asn Arg Val Asn Asp Pro Leu Ile Phe Ile Arg Asp Ile Lys Pro
 1               5                  10                  15      
Gly Leu Lys Asn Leu Asn Val Val Phe Ile Val Leu Glu Ile Gly Arg
            20                  25                  30          
Val Thr Lys Thr Lys Asp Gly His Glu Val Arg Ser Cys Lys Val Ala
        35                  40                  45              
Asp Lys Thr Gly Ser Ile Thr Ile Ser Val Trp Asp Glu Ile Gly Gly
    50                  55                  60                  
Leu Ile Gln Pro Gly Asp Ile Ile Arg Leu Thr Arg Gly Tyr Ala Ser
65                  70                  75                  80  
Met Trp Lys Gly Cys Leu Thr Leu Tyr Thr Gly Arg Gly Gly Glu Leu
                85                  90                  95      
Gln Lys Ile Gly Glu Phe Cys Met Val Tyr Ser Glu Val Pro Asn Phe
            100                 105                 110         
Ser Glu Pro Asn Pro Asp Tyr Arg Gly Gln Gln Asn Lys Gly Ala Gln
        115                 120                 125             
Ser Glu Gln Lys Asn Asn Ser Met Asn Ser Asn Met Gly Thr Gly Thr
    130                 135                 140                 
Phe Gly Pro Val Gly Asn Gly Val His Thr Gly Pro Glu Ser Arg Glu
145                 150                 155                 160 
His Gln Phe Ser His Ala Gly Arg Ser Asn Gly Arg Gly Leu Ile Asn
                165                 170                 175     
Pro Gln Leu Gln Gly Thr Ala Ser Asn Gln Thr Val Met Thr Thr Ile
            180                 185                 190         
Ser Asn Gly Arg Asp Pro Arg Arg Ala Phe Lys Arg
        195                 200                 


<210> 6241
<211> 1501
<212> PRT
<213> Homo sapiens

<400> 6241
Met Cys Lys Met Ala Ile Ile Pro Asp Trp Leu Arg Ser His Pro His
 1               5                  10                  15      
Thr Arg Lys Phe Thr His Ser Arg Pro His Ser Ser Pro Cys Arg Val
            20                  25                  30          
Tyr Ser Arg Asn Gly Ser Pro Asn Lys Phe Arg Ser Ser Ser Thr Thr
        35                  40                  45              
Ala Val Ala Asn Pro Thr Leu Ser Ser Leu Asp Val Lys Arg Ile Leu
    50                  55                  60                  
Phe Gln Lys Ile Thr Asp Arg Gly Asp Glu Leu Gln Lys Ala Phe Gln
65                  70                  75                  80  
Leu Leu Asp Thr Gly Gln Asn Leu Thr Val Ser Lys Ser Glu Leu Arg
                85                  90                  95      
Arg Ile Ile Thr Asp Phe Leu Met Pro Leu Thr Arg Glu Gln Phe Gln
            100                 105                 110         
Asp Val Leu Ala Gln Ile Pro Leu Ser Thr Ser Gly Thr Val Pro Tyr
        115                 120                 125             
Leu Ala Phe Leu Ser Arg Phe Gly Gly Ile Asp Leu Tyr Ile Asn Gly
    130                 135                 140                 
Ile Lys Arg Gly Gly Gly Asn Glu Met Asn Cys Cys Arg Thr Leu Arg
145                 150                 155                 160 
Glu Leu Glu Ile Gln Val Gly Glu Lys Val Phe Lys Asn Ile Lys Thr
                165                 170                 175     
Val Met Lys Ala Phe Glu Leu Ile Asp Val Asn Lys Thr Gly Leu Val
            180                 185                 190         
Arg Pro Gln Glu Leu Arg Arg Val Leu Glu Thr Phe Cys Met Lys Leu
        195                 200                 205             
Arg Asp Glu Glu Tyr Glu Lys Phe Ser Lys His Tyr Asn Ile His Lys
    210                 215                 220                 
Asp Thr Ala Val Asp Tyr Asn Val Phe Leu Lys Asn Leu Ser Ile Asn
225                 230                 235                 240 
Asn Asp Leu Asn Leu Arg Tyr Cys Met Gly Asn Gln Glu Val Ser Leu
                245                 250                 255     
Glu Asn Gln Gln Ala Lys Asn Ser Lys Lys Glu Arg Leu Leu Gly Ser
            260                 265                 270         
Ala Ser Ser Glu Asp Ile Trp Arg Asn Tyr Ser Leu Asp Glu Ile Glu
        275                 280                 285             
Arg Asn Phe Cys Leu Gln Leu Ser Lys Ser Tyr Glu Lys Val Glu Lys
    290                 295                 300                 
Ala Leu Ser Ala Gly Asp Pro Cys Lys Gly Gly Tyr Val Ser Phe Asn
305                 310                 315                 320 
Tyr Leu Lys Ile Val Leu Asp Thr Phe Val Tyr Gln Ile Pro Arg Arg
                325                 330                 335     
Ile Phe Ile Gln Leu Met Lys Arg Phe Gly Leu Lys Ala Thr Thr Lys
            340                 345                 350         
Ile Asn Trp Lys Gln Phe Leu Thr Ser Phe His Glu Pro Gln Gly Leu
        355                 360                 365             
Gln Val Ser Ser Lys Gly Pro Leu Thr Lys Arg Asn Ser Ile Asn Ser
    370                 375                 380                 
Arg Asn Glu Ser His Lys Glu Asn Ile Ile Thr Lys Leu Phe Arg His
385                 390                 395                 400 
Thr Glu Asp His Ser Ala Ser Leu Lys Lys Ala Leu Leu Ile Ile Asn
                405                 410                 415     
Thr Lys Pro Asp Gly Pro Ile Thr Arg Glu Glu Phe Arg Tyr Ile Leu
            420                 425                 430         
Asn Cys Met Ala Val Lys Leu Ser Asp Ser Glu Phe Lys Glu Leu Met
        435                 440                 445             
Gln Met Leu Asp Pro Gly Asp Thr Gly Val Val Asn Thr Ser Met Phe
    450                 455                 460                 
Ile Asp Leu Ile Glu Glu Asn Cys Arg Met Arg Lys Thr Ser Pro Cys
465                 470                 475                 480 
Thr Asp Ala Lys Thr Pro Phe Leu Leu Ala Trp Asp Ser Val Glu Glu
                485                 490                 495     
Ile Val His Asp Thr Ile Thr Arg Asn Leu Gln Ala Phe Tyr Asn Met
            500                 505                 510         
Leu Arg Ser Tyr Asp Leu Gly Asp Thr Gly Arg Ile Gly Arg Asn Asn
        515                 520                 525             
Phe Lys Lys Ile Met His Val Phe Cys Pro Phe Leu Thr Asn Ala His
    530                 535                 540                 
Phe Ile Lys Leu Cys Ser Lys Ile Gln Asp Ile Gly Ser Gly Arg Ile
545                 550                 555                 560 
Leu Tyr Lys Lys Leu Leu Ala Cys Ile Gly Ile Asp Gly Pro Pro Thr
                565                 570                 575     
Val Ser Pro Val Leu Val Pro Lys Asp Gln Leu Leu Ser Glu His Leu
            580                 585                 590         
Gln Lys Asp Glu Gln Gln Gln Pro Asp Leu Ser Glu Arg Thr Lys Leu
        595                 600                 605             
Thr Glu Asp Lys Thr Thr Leu Thr Lys Lys Met Thr Thr Glu Glu Val
    610                 615                 620                 
Ile Glu Lys Phe Lys Lys Cys Ile Gln Gln Gln Asp Pro Ala Phe Lys
625                 630                 635                 640 
Lys Arg Phe Leu Asp Phe Ser Lys Glu Pro Asn Gly Lys Ile Asn Val
                645                 650                 655     
His Asp Phe Lys Lys Val Leu Glu Asp Thr Gly Met Pro Met Asp Asp
            660                 665                 670         
Asp Gln Tyr Ala Leu Leu Thr Thr Lys Ile Gly Phe Glu Lys Glu Gly
        675                 680                 685             
Met Ser Tyr Leu Asp Phe Ala Ala Gly Phe Glu Asp Pro Pro Met Arg
    690                 695                 700                 
Gly Pro Glu Thr Thr Pro Pro Gln Pro Pro Thr Pro Ser Lys Ser Tyr
705                 710                 715                 720 
Val Asn Ser His Phe Ile Thr Ala Glu Glu Cys Leu Lys Leu Phe Pro
                725                 730                 735     
Arg Arg Leu Lys Glu Ser Phe Arg Asp Pro Tyr Ser Ala Phe Phe Lys
            740                 745                 750         
Thr Asp Ala Asp Arg Asp Gly Ile Ile Asn Met His Asp Leu His Arg
        755                 760                 765             
Leu Leu Leu His Leu Leu Leu Asn Leu Lys Asp Asp Glu Phe Glu Arg
    770                 775                 780                 
Phe Leu Gly Leu Leu Gly Leu Arg Leu Ser Val Thr Leu Asn Phe Arg
785                 790                 795                 800 
Glu Phe Gln Asn Leu Cys Glu Lys Arg Pro Trp Arg Thr Asp Glu Ala
                805                 810                 815     
Pro Gln Arg Leu Ile Arg Pro Lys Gln Lys Val Ala Asp Ser Glu Leu
            820                 825                 830         
Ala Cys Glu Gln Ala His Gln Tyr Leu Val Thr Lys Ala Lys Asn Arg
        835                 840                 845             
Trp Ser Asp Leu Ser Lys Asn Phe Leu Glu Thr Asp Asn Glu Gly Asn
    850                 855                 860                 
Gly Ile Leu Arg Arg Arg Asp Ile Lys Asn Ala Leu Tyr Gly Phe Asp
865                 870                 875                 880 
Ile Pro Leu Thr Pro Arg Glu Phe Glu Lys Leu Trp Ala Arg Tyr Asp
                885                 890                 895     
Thr Glu Gly Lys Gly His Ile Thr Tyr Gln Glu Phe Leu Gln Lys Leu
            900                 905                 910         
Gly Ile Asn Tyr Ser Pro Ala Val His Arg Pro Cys Ala Glu Asp Tyr
        915                 920                 925             
Phe Asn Phe Met Gly His Phe Thr Lys Pro Gln Gln Leu Gln Glu Glu
    930                 935                 940                 
Met Lys Glu Leu Gln Gln Ser Thr Glu Lys Ala Val Ala Ala Arg Asp
945                 950                 955                 960 
Lys Leu Met Asp Arg His Gln Asp Ile Ser Lys Ala Phe Thr Lys Thr
                965                 970                 975     
Asp Gln Ser Lys Thr Asn Tyr Ile Ser Ile Cys Lys Met Gln Glu Val
            980                 985                 990         
Leu Glu Glu Cys Gly Cys Ser Leu Thr Glu Gly Glu Leu Thr His Leu
        995                 1000                1005            
Leu Asn Ser Trp Gly Val Ser Arg His Asp Asn Ala Ile Asn Tyr Leu
    1010                1015                1020                
Asp Phe Leu Arg Ala Val Glu Asn Ser Lys Ser Thr Gly Ala Gln Pro
1025                1030                1035                1040
Lys Glu Lys Glu Glu Ser Met Pro Ile Asn Phe Ala Thr Leu Asn Pro
                1045                1050                1055    
Gln Glu Ala Val Arg Lys Ile Gln Glu Val Val Glu Ser Ser Gln Leu
            1060                1065                1070        
Ala Leu Ser Thr Ala Phe Ser Ala Leu Asp Lys Glu Asp Thr Gly Phe
        1075                1080                1085            
Val Lys Ala Thr Glu Phe Gly Gln Val Leu Lys Asp Phe Cys Tyr Lys
    1090                1095                1100                
Leu Thr Asp Asn Gln Tyr His Tyr Phe Leu Arg Lys Leu Arg Ile His
1105                1110                1115                1120
Leu Thr Pro Tyr Ile Asn Trp Lys Tyr Phe Leu Gln Asn Phe Ser Cys
                1125                1130                1135    
Phe Leu Glu Glu Thr Ala Asp Glu Trp Ala Glu Lys Met Pro Lys Gly
            1140                1145                1150        
Pro Pro Pro Thr Ser Pro Lys Ala Thr Ala Asp Arg Asp Ile Leu Ala
        1155                1160                1165            
Arg Leu His Lys Ala Val Thr Ser His Tyr His Ala Ile Thr Gln Glu
    1170                1175                1180                
Phe Glu Asn Phe Asp Thr Met Lys Thr Asn Thr Ile Ser Arg Glu Glu
1185                1190                1195                1200
Phe Arg Ala Ile Cys Asn Arg Arg Val Gln Ile Leu Thr Asp Glu Gln
                1205                1210                1215    
Phe Asp Arg Leu Trp Asn Glu Met Pro Val Asn Ala Lys Gly Arg Leu
            1220                1225                1230        
Lys Tyr Pro Asp Phe Leu Ser Arg Phe Ser Ser Glu Thr Ala Ala Thr
        1235                1240                1245            
Pro Met Ala Thr Gly Asp Ser Ala Val Ala Gln Arg Gly Ser Ser Val
    1250                1255                1260                
Pro Asp Val Ser Glu Gly Thr Arg Ser Ala Leu Ser Leu Pro Thr Gln
1265                1270                1275                1280
Glu Leu Arg Pro Gly Ser Lys Ser Gln Ser His Pro Cys Thr Pro Ala
                1285                1290                1295    
Ser Thr Thr Val Ile Pro Gly Thr Pro Pro Leu Gln Asn Cys Asp Pro
            1300                1305                1310        
Ile Glu Ser Arg Leu Arg Lys Arg Ile Gln Gly Cys Trp Arg Gln Leu
        1315                1320                1325            
Leu Lys Glu Cys Lys Glu Lys Asp Val Ala Arg Gln Gly Asp Ile Asn
    1330                1335                1340                
Ala Ser Asp Phe Leu Ala Leu Val Glu Lys Phe Asn Leu Asp Ile Ser
1345                1350                1355                1360
Lys Glu Glu Cys Gln Gln Leu Ile Ile Lys Tyr Asp Leu Lys Ser Asn
                1365                1370                1375    
Gly Lys Phe Ala Tyr Cys Asp Phe Ile Gln Ser Cys Val Leu Leu Leu
            1380                1385                1390        
Lys Ala Lys Glu Ser Ser Leu Met His Arg Met Lys Ile Gln Asn Ala
        1395                1400                1405            
His Lys Met Lys Glu Ala Gly Ala Glu Thr Pro Ser Phe Tyr Ser Ala
    1410                1415                1420                
Leu Leu Arg Ile Gln Pro Lys Ile Val His Cys Trp Arg Pro Met Arg
1425                1430                1435                1440
Arg Thr Phe Lys Ser Tyr Asp Glu Ala Gly Thr Gly Leu Leu Ser Val
                1445                1450                1455    
Ala Asp Phe Arg Thr Val Leu Arg Gln Tyr Ser Ile Asn Leu Ser Glu
            1460                1465                1470        
Glu Glu Phe Phe His Ile Leu Glu Tyr Tyr Asp Lys Thr Leu Ser Ser
        1475                1480                1485            
Lys Ile Ser Tyr Asn Asp Phe Leu Arg Ala Phe Leu Gln
    1490                1495                1500    


<210> 6242
<211> 1349
<212> PRT
<213> Homo sapiens

<400> 6242
Met Asn Cys Cys Arg Thr Leu Arg Glu Leu Glu Ile Gln Val Gly Glu
 1               5                  10                  15      
Lys Val Phe Lys Asn Ile Lys Thr Val Met Lys Ala Phe Glu Leu Ile
            20                  25                  30          
Asp Val Asn Lys Thr Gly Leu Val Arg Pro Gln Glu Leu Arg Arg Val
        35                  40                  45              
Leu Glu Thr Phe Cys Met Lys Leu Arg Asp Glu Glu Tyr Glu Lys Phe
    50                  55                  60                  
Ser Lys His Tyr Asn Ile His Lys Asp Thr Ala Val Asp Tyr Asn Val
65                  70                  75                  80  
Phe Leu Lys Asn Leu Ser Ile Asn Asn Asp Leu Asn Leu Arg Tyr Cys
                85                  90                  95      
Met Gly Asn Gln Glu Val Ser Leu Glu Asn Gln Gln Ala Lys Asn Ser
            100                 105                 110         
Lys Lys Glu Arg Leu Leu Gly Ser Ala Ser Ser Glu Asp Ile Trp Arg
        115                 120                 125             
Asn Tyr Ser Leu Asp Glu Ile Glu Arg Asn Phe Cys Leu Gln Leu Ser
    130                 135                 140                 
Lys Ser Tyr Glu Lys Val Glu Lys Ala Leu Ser Ala Gly Asp Pro Cys
145                 150                 155                 160 
Lys Gly Gly Tyr Val Ser Phe Asn Tyr Leu Lys Ile Val Leu Asp Thr
                165                 170                 175     
Phe Val Tyr Gln Ile Pro Arg Arg Ile Phe Ile Gln Leu Met Lys Arg
            180                 185                 190         
Phe Gly Leu Lys Ala Thr Thr Lys Ile Asn Trp Lys Gln Phe Leu Thr
        195                 200                 205             
Ser Phe His Glu Pro Gln Gly Leu Gln Val Ser Ser Lys Gly Pro Leu
    210                 215                 220                 
Thr Lys Arg Asn Ser Ile Asn Ser Arg Asn Glu Ser His Lys Glu Asn
225                 230                 235                 240 
Ile Ile Thr Lys Leu Phe Arg His Thr Glu Asp His Ser Ala Ser Leu
                245                 250                 255     
Lys Lys Ala Leu Leu Ile Ile Asn Thr Lys Pro Asp Gly Pro Ile Thr
            260                 265                 270         
Arg Glu Glu Phe Arg Tyr Ile Leu Asn Cys Met Ala Val Lys Leu Ser
        275                 280                 285             
Asp Ser Glu Phe Lys Glu Leu Met Gln Met Leu Asp Pro Gly Asp Thr
    290                 295                 300                 
Gly Val Val Asn Thr Ser Met Phe Ile Asp Leu Ile Glu Glu Asn Cys
305                 310                 315                 320 
Arg Met Arg Lys Thr Ser Pro Cys Thr Asp Ala Lys Thr Pro Phe Leu
                325                 330                 335     
Leu Ala Trp Asp Ser Val Glu Glu Ile Val His Asp Thr Ile Thr Arg
            340                 345                 350         
Asn Leu Gln Ala Phe Tyr Asn Met Leu Arg Ser Tyr Asp Leu Gly Asp
        355                 360                 365             
Thr Gly Arg Ile Gly Arg Asn Asn Phe Lys Lys Ile Met His Val Phe
    370                 375                 380                 
Cys Pro Phe Leu Thr Asn Ala His Phe Ile Lys Leu Cys Ser Lys Ile
385                 390                 395                 400 
Gln Asp Ile Gly Ser Gly Arg Ile Leu Tyr Lys Lys Leu Leu Ala Cys
                405                 410                 415     
Ile Gly Ile Asp Gly Pro Pro Thr Val Ser Pro Val Leu Val Pro Lys
            420                 425                 430         
Asp Gln Leu Leu Ser Glu His Leu Gln Lys Asp Glu Gln Gln Gln Pro
        435                 440                 445             
Asp Leu Ser Glu Arg Thr Lys Leu Thr Glu Asp Lys Thr Thr Leu Thr
    450                 455                 460                 
Lys Lys Met Thr Thr Glu Glu Val Ile Glu Lys Phe Lys Lys Cys Ile
465                 470                 475                 480 
Gln Gln Gln Asp Pro Ala Phe Lys Lys Arg Phe Leu Asp Phe Ser Lys
                485                 490                 495     
Glu Pro Asn Gly Lys Ile Asn Val His Asp Phe Lys Lys Val Leu Glu
            500                 505                 510         
Asp Thr Gly Met Pro Met Asp Asp Asp Gln Tyr Ala Leu Leu Thr Thr
        515                 520                 525             
Lys Ile Gly Phe Glu Lys Glu Gly Met Ser Tyr Leu Asp Phe Ala Ala
    530                 535                 540                 
Gly Phe Glu Asp Pro Pro Met Arg Gly Pro Glu Thr Thr Pro Pro Gln
545                 550                 555                 560 
Pro Pro Thr Pro Ser Lys Ser Tyr Val Asn Ser His Phe Ile Thr Ala
                565                 570                 575     
Glu Glu Cys Leu Lys Leu Phe Pro Arg Arg Leu Lys Glu Ser Phe Arg
            580                 585                 590         
Asp Pro Tyr Ser Ala Phe Phe Lys Thr Asp Ala Asp Arg Asp Gly Ile
        595                 600                 605             
Ile Asn Met His Asp Leu His Arg Leu Leu Leu His Leu Leu Leu Asn
    610                 615                 620                 
Leu Lys Asp Asp Glu Phe Glu Arg Phe Leu Gly Leu Leu Gly Leu Arg
625                 630                 635                 640 
Leu Ser Val Thr Leu Asn Phe Arg Glu Phe Gln Asn Leu Cys Glu Lys
                645                 650                 655     
Arg Pro Trp Arg Thr Asp Glu Ala Pro Gln Arg Leu Ile Arg Pro Lys
            660                 665                 670         
Gln Lys Val Ala Asp Ser Glu Leu Ala Cys Glu Gln Ala His Gln Tyr
        675                 680                 685             
Leu Val Thr Lys Ala Lys Asn Arg Trp Ser Asp Leu Ser Lys Asn Phe
    690                 695                 700                 
Leu Glu Thr Asp Asn Glu Gly Asn Gly Ile Leu Arg Arg Arg Asp Ile
705                 710                 715                 720 
Lys Asn Ala Leu Tyr Gly Phe Asp Ile Pro Leu Thr Pro Arg Glu Phe
                725                 730                 735     
Glu Lys Leu Trp Ala Arg Tyr Asp Thr Glu Gly Lys Gly His Ile Thr
            740                 745                 750         
Tyr Gln Glu Phe Leu Gln Lys Leu Gly Ile Asn Tyr Ser Pro Ala Val
        755                 760                 765             
His Arg Pro Cys Ala Glu Asp Tyr Phe Asn Phe Met Gly His Phe Thr
    770                 775                 780                 
Lys Pro Gln Gln Leu Gln Glu Glu Met Lys Glu Leu Gln Gln Ser Thr
785                 790                 795                 800 
Glu Lys Ala Val Ala Ala Arg Asp Lys Leu Met Asp Arg His Gln Asp
                805                 810                 815     
Ile Ser Lys Ala Phe Thr Lys Thr Asp Gln Ser Lys Thr Asn Tyr Ile
            820                 825                 830         
Ser Ile Cys Lys Met Gln Glu Val Leu Glu Glu Cys Gly Cys Ser Leu
        835                 840                 845             
Thr Glu Gly Glu Leu Thr His Leu Leu Asn Ser Trp Gly Val Ser Arg
    850                 855                 860                 
His Asp Asn Ala Ile Asn Tyr Leu Asp Phe Leu Arg Ala Val Glu Asn
865                 870                 875                 880 
Ser Lys Ser Thr Gly Ala Gln Pro Lys Glu Lys Glu Glu Ser Met Pro
                885                 890                 895     
Ile Asn Phe Ala Thr Leu Asn Pro Gln Glu Ala Val Arg Lys Ile Gln
            900                 905                 910         
Glu Val Val Glu Ser Ser Gln Leu Ala Leu Ser Thr Ala Phe Ser Ala
        915                 920                 925             
Leu Asp Lys Glu Asp Thr Gly Phe Val Lys Ala Thr Glu Phe Gly Gln
    930                 935                 940                 
Val Leu Lys Asp Phe Cys Tyr Lys Leu Thr Asp Asn Gln Tyr His Tyr
945                 950                 955                 960 
Phe Leu Arg Lys Leu Arg Ile His Leu Thr Pro Tyr Ile Asn Trp Lys
                965                 970                 975     
Tyr Phe Leu Gln Asn Phe Ser Cys Phe Leu Glu Glu Thr Ala Asp Glu
            980                 985                 990         
Trp Ala Glu Lys Met Pro Lys Gly Pro Pro Pro Thr Ser Pro Lys Ala
        995                 1000                1005            
Thr Ala Asp Arg Asp Ile Leu Ala Arg Leu His Lys Ala Val Thr Ser
    1010                1015                1020                
His Tyr His Ala Ile Thr Gln Glu Phe Glu Asn Phe Asp Thr Met Lys
1025                1030                1035                1040
Thr Asn Thr Ile Ser Arg Glu Glu Phe Arg Ala Ile Cys Asn Arg Arg
                1045                1050                1055    
Val Gln Ile Leu Thr Asp Glu Gln Phe Asp Arg Leu Trp Asn Glu Met
            1060                1065                1070        
Pro Val Asn Ala Lys Gly Arg Leu Lys Tyr Pro Asp Phe Leu Ser Arg
        1075                1080                1085            
Phe Ser Ser Glu Thr Ala Ala Thr Pro Met Ala Thr Gly Asp Ser Ala
    1090                1095                1100                
Val Ala Gln Arg Gly Ser Ser Val Pro Asp Val Ser Glu Gly Thr Arg
1105                1110                1115                1120
Ser Ala Leu Ser Leu Pro Thr Gln Glu Leu Arg Pro Gly Ser Lys Ser
                1125                1130                1135    
Gln Ser His Pro Cys Thr Pro Ala Ser Thr Thr Val Ile Pro Gly Thr
            1140                1145                1150        
Pro Pro Leu Gln Asn Cys Asp Pro Ile Glu Ser Arg Leu Arg Lys Arg
        1155                1160                1165            
Ile Gln Gly Cys Trp Arg Gln Leu Leu Lys Glu Cys Lys Glu Lys Asp
    1170                1175                1180                
Val Ala Arg Gln Gly Asp Ile Asn Ala Ser Asp Phe Leu Ala Leu Val
1185                1190                1195                1200
Glu Lys Phe Asn Leu Asp Ile Ser Lys Glu Glu Cys Gln Gln Leu Ile
                1205                1210                1215    
Ile Lys Tyr Asp Leu Lys Ser Asn Gly Lys Phe Ala Tyr Cys Asp Phe
            1220                1225                1230        
Ile Gln Ser Cys Val Leu Leu Leu Lys Ala Lys Glu Ser Ser Leu Met
        1235                1240                1245            
His Arg Met Lys Ile Gln Asn Ala His Lys Met Lys Glu Ala Gly Ala
    1250                1255                1260                
Glu Thr Pro Ser Phe Tyr Ser Ala Leu Leu Arg Ile Gln Pro Lys Ile
1265                1270                1275                1280
Val His Cys Trp Arg Pro Met Arg Arg Thr Phe Lys Ser Tyr Asp Glu
                1285                1290                1295    
Ala Gly Thr Gly Leu Leu Ser Val Ala Asp Phe Arg Thr Val Leu Arg
            1300                1305                1310        
Gln Tyr Ser Ile Asn Leu Ser Glu Glu Glu Phe Phe His Ile Leu Glu
        1315                1320                1325            
Tyr Tyr Asp Lys Thr Leu Ser Ser Lys Ile Ser Tyr Asn Asp Phe Leu
    1330                1335                1340                
Arg Ala Phe Leu Gln
1345                


<210> 6243
<211> 225
<212> PRT
<213> Homo sapiens

<400> 6243
Arg Arg Arg Ile Leu Thr His Glu Asn Leu His Ile Gln Asp Pro Ile
 1               5                  10                  15      
Leu His Arg Val Glu Cys Ile Gln Gly Met Val Pro Gln Ile Ser Ser
            20                  25                  30          
Asp Leu Leu Gln Ile Pro Leu Ser Thr Ser Gly Thr Val Pro Tyr Leu
        35                  40                  45              
Ala Phe Leu Ser Arg Phe Gly Gly Ile Asp Leu Tyr Ile Asn Gly Ile
    50                  55                  60                  
Lys Arg Gly Gly Gly Asn Glu Met Asn Cys Cys Arg Thr Leu Arg Glu
65                  70                  75                  80  
Leu Glu Ile Gln Val Gly Glu Lys Val Phe Lys Asn Ile Lys Thr Val
                85                  90                  95      
Met Lys Ala Phe Glu Leu Ile Asp Val Asn Lys Thr Gly Leu Val Arg
            100                 105                 110         
Pro Gln Glu Leu Arg Arg Val Leu Glu Thr Phe Cys Met Lys Leu Arg
        115                 120                 125             
Asp Glu Glu Tyr Glu Lys Phe Ser Lys His Tyr Asn Ile His Lys Asp
    130                 135                 140                 
Thr Ala Val Asp Tyr Asn Val Phe Leu Lys Asn Leu Ser Ile Asn Asn
145                 150                 155                 160 
Asp Leu Asn Leu Arg Tyr Cys Met Gly Asn Gln Glu Val Ser Leu Glu
                165                 170                 175     
Asn Gln Gln Ala Lys Asn Ser Lys Lys Glu Arg Leu Leu Gly Ser Ala
            180                 185                 190         
Ser Ser Glu Asp Ile Trp Arg Asn Tyr Ser Leu Asp Glu Ile Glu Arg
        195                 200                 205             
Asn Phe Cys Leu Gln Val Arg Cys Phe Pro Lys Pro Gln Leu Pro Thr
    210                 215                 220                 
Glu
225 


<210> 6244
<211> 866
<212> PRT
<213> Homo sapiens

<400> 6244
Met Leu Arg Pro Gly Ala Gln Leu Leu Arg Gly Leu Leu Leu Arg Ser
 1               5                  10                  15      
Cys Pro Leu Gln Gly Ser Pro Gly Arg Pro Arg Ser Val Cys Gly Arg
            20                  25                  30          
Glu Gly Glu Glu Lys Pro Pro Leu Ser Ala Glu Thr Gln Trp Lys Asp
        35                  40                  45              
Arg Ala Glu Thr Val Ile Ile Gly Gly Gly Cys Val Gly Val Ser Leu
    50                  55                  60                  
Ala Tyr His Leu Ala Lys Ala Gly Met Lys Asp Val Val Leu Leu Glu
65                  70                  75                  80  
Lys Ser Glu Leu Thr Ala Gly Ser Thr Trp His Ala Ala Gly Leu Thr
                85                  90                  95      
Thr Tyr Phe His Pro Gly Ile Asn Leu Lys Lys Ile His Tyr Asp Ser
            100                 105                 110         
Ile Lys Leu Tyr Glu Lys Leu Glu Glu Glu Thr Gly Gln Val Val Gly
        115                 120                 125             
Phe His Gln Pro Gly Ser Ile Arg Leu Ala Thr Thr Pro Val Arg Val
    130                 135                 140                 
Asp Glu Phe Lys Tyr Gln Met Thr Arg Thr Gly Trp His Ala Thr Glu
145                 150                 155                 160 
Gln Tyr Leu Ile Glu Pro Glu Lys Ile Gln Glu Met Phe Pro Leu Leu
                165                 170                 175     
Asn Met Asn Lys Val Leu Ala Gly Leu Tyr Asn Pro Gly Asp Gly His
            180                 185                 190         
Ile Asp Pro Tyr Ser Leu Thr Met Ala Leu Ala Ala Gly Ala Arg Lys
        195                 200                 205             
Cys Gly Ala Leu Leu Lys Tyr Pro Ala Pro Val Thr Ser Leu Lys Ala
    210                 215                 220                 
Arg Ser Asp Gly Thr Trp Asp Val Glu Thr Pro Gln Gly Ser Met Arg
225                 230                 235                 240 
Ala Asn Arg Ile Val Asn Ala Ala Gly Phe Trp Ala Arg Glu Val Gly
                245                 250                 255     
Lys Met Ile Gly Leu Glu His Pro Leu Ile Pro Val Gln His Gln Tyr
            260                 265                 270         
Val Val Thr Ser Thr Ile Ser Glu Val Lys Ala Leu Lys Arg Glu Leu
        275                 280                 285             
Pro Val Leu Arg Asp Leu Glu Gly Ser Tyr Tyr Leu Arg Gln Glu Arg
    290                 295                 300                 
Asp Gly Leu Leu Phe Gly Pro Tyr Glu Ser Gln Glu Lys Met Lys Val
305                 310                 315                 320 
Gln Asp Ser Trp Val Thr Asn Gly Val Pro Pro Gly Phe Gly Lys Glu
                325                 330                 335     
Leu Phe Glu Ser Asp Leu Asp Arg Ile Met Glu His Ile Lys Ala Ala
            340                 345                 350         
Met Glu Met Val Pro Val Leu Lys Lys Ala Asp Ile Ile Asn Val Val
        355                 360                 365             
Asn Gly Pro Ile Thr Tyr Ser Pro Asp Ile Leu Pro Met Val Gly Pro
    370                 375                 380                 
His Gln Gly Val Arg Asn Tyr Trp Val Ala Ile Gly Phe Gly Tyr Gly
385                 390                 395                 400 
Ile Ile His Ala Gly Gly Val Gly Lys Tyr Leu Ser Asp Trp Ile Leu
                405                 410                 415     
His Gly Glu Pro Pro Phe Asp Leu Ile Glu Leu Asp Pro Asn Arg Tyr
            420                 425                 430         
Gly Lys Trp Thr Thr Thr Gln Tyr Thr Glu Ala Lys Ala Arg Glu Ser
        435                 440                 445             
Tyr Gly Phe Asn Asn Ile Val Gly Tyr Pro Lys Glu Glu Arg Phe Ala
    450                 455                 460                 
Gly Arg Pro Thr Gln Arg Val Ser Gly Leu Tyr Gln Arg Leu Glu Ser
465                 470                 475                 480 
Lys Cys Ser Met Gly Phe His Ala Gly Trp Glu Gln Pro His Trp Phe
                485                 490                 495     
Tyr Lys Pro Gly Gln Asp Thr Gln Tyr Arg Pro Ser Phe Arg Arg Thr
            500                 505                 510         
Asn Trp Phe Glu Pro Val Gly Ser Glu Tyr Lys Gln Val Met Gln Arg
        515                 520                 525             
Val Gly Val Thr Asp Leu Ser Pro Phe Gly Lys Phe Asn Ile Lys Gly
    530                 535                 540                 
Gln Asp Ser Ile Arg Leu Leu Asp His Leu Phe Ala Asn Val Ile Pro
545                 550                 555                 560 
Lys Val Gly Phe Thr Asn Ile Ser His Met Leu Thr Pro Lys Gly Arg
                565                 570                 575     
Val Tyr Ala Glu Leu Thr Val Ser His Gln Ser Pro Gly Glu Phe Leu
            580                 585                 590         
Leu Ile Thr Gly Ser Gly Ser Glu Leu His Asp Leu Arg Trp Ile Glu
        595                 600                 605             
Glu Glu Ala Val Lys Gly Gly Tyr Asp Val Glu Ile Lys Asn Ile Thr
    610                 615                 620                 
Asp Glu Leu Gly Val Leu Gly Val Ala Gly Pro Gln Ala Arg Lys Val
625                 630                 635                 640 
Leu Gln Lys Leu Thr Pro Glu Asp Leu Ser Asp Asp Val Phe Lys Phe
                645                 650                 655     
Leu Gln Thr Lys Ser Leu Lys Val Ser Asn Ile Pro Val Thr Ala Ile
            660                 665                 670         
Arg Ile Ser Tyr Thr Gly Glu Leu Gly Trp Glu Leu Tyr His Arg Arg
        675                 680                 685             
Glu Asp Ser Val Ala Leu Tyr Asp Ala Ile Met Asn Ala Gly Gln Glu
    690                 695                 700                 
Glu Gly Ile Asp Asn Phe Gly Thr Tyr Ala Met Asn Ala Leu Arg Leu
705                 710                 715                 720 
Glu Lys Ala Phe Arg Ala Trp Gly Leu Glu Met Asn Cys Asp Thr Asn
                725                 730                 735     
Pro Leu Glu Ala Gly Leu Glu Tyr Phe Val Lys Leu Asn Lys Pro Ala
            740                 745                 750         
Asp Phe Ile Gly Lys Gln Ala Leu Lys Gln Ile Lys Ala Lys Gly Leu
        755                 760                 765             
Lys Arg Arg Leu Val Cys Leu Thr Leu Ala Thr Asp Asp Val Asp Pro
    770                 775                 780                 
Glu Gly Asn Glu Ser Ile Trp Tyr Asn Gly Lys Val Val Gly Asn Thr
785                 790                 795                 800 
Thr Ser Gly Ser Tyr Ser Tyr Ser Ile Gln Lys Ser Leu Ala Phe Ala
                805                 810                 815     
Tyr Val Pro Val Gln Leu Ser Glu Val Gly Gln Gln Val Glu Val Glu
            820                 825                 830         
Leu Leu Gly Lys Asn Tyr Pro Ala Val Ile Ile Gln Glu Pro Leu Val
        835                 840                 845             
Leu Thr Glu Pro Thr Arg Asn Arg Leu Gln Lys Lys Gly Gly Lys Asp
    850                 855                 860                 
Lys Thr
865     


<210> 6245
<211> 613
<212> PRT
<213> Homo sapiens

<400> 6245
Tyr Leu Ile Glu Pro Glu Lys Ile Gln Glu Met Phe Pro Leu Leu Asn
 1               5                  10                  15      
Met Asn Lys Val Leu Ala Gly Leu Tyr Asn Pro Gly Asp Gly His Ile
            20                  25                  30          
Asp Pro Tyr Ser Leu Thr Met Ala Leu Ala Ala Gly Ala Arg Lys Cys
        35                  40                  45              
Gly Ala Leu Leu Lys Tyr Pro Ala Pro Val Thr Ser Leu Lys Ala Arg
    50                  55                  60                  
Ser Asp Gly Thr Trp Asp Val Glu Thr Pro Gln Gly Ser Met Arg Ala
65                  70                  75                  80  
Asn Arg Ile Val Asn Ala Ala Gly Phe Trp Ala Arg Glu Val Gly Lys
                85                  90                  95      
Met Ile Gly Leu Glu His Pro Leu Ile Pro Val Gln His Gln Tyr Val
            100                 105                 110         
Val Thr Ser Thr Ile Ser Glu Val Lys Ala Leu Lys Arg Glu Leu Pro
        115                 120                 125             
Val Leu Arg Asp Leu Glu Gly Ser Tyr Tyr Leu Arg Gln Glu Arg Asp
    130                 135                 140                 
Gly Leu Leu Phe Gly Pro Tyr Glu Ser Gln Glu Lys Met Lys Val Gln
145                 150                 155                 160 
Asp Ser Trp Val Thr Asn Gly Val Pro Pro Gly Phe Gly Lys Glu Leu
                165                 170                 175     
Phe Glu Ser Asp Leu Asp Arg Ile Met Glu His Ile Lys Ala Ala Met
            180                 185                 190         
Glu Met Val Pro Val Leu Lys Lys Ala Asp Ile Ile Asn Val Val Asn
        195                 200                 205             
Gly Pro Ile Thr Tyr Ser Pro Asp Ile Leu Pro Met Val Gly Pro His
    210                 215                 220                 
Gln Gly Val Arg Asn Tyr Trp Val Ala Ile Gly Phe Gly Tyr Gly Ile
225                 230                 235                 240 
Ile His Ala Gly Gly Val Gly Lys Tyr Leu Ser Asp Trp Ile Leu His
                245                 250                 255     
Gly Glu Pro Pro Phe Asp Leu Ile Glu Leu Asp Pro Asn Arg Tyr Gly
            260                 265                 270         
Lys Trp Thr Thr Thr Gln Tyr Thr Glu Ala Lys Ala Arg Glu Ser Tyr
        275                 280                 285             
Gly Phe Asn Asn Ile Val Gly Tyr Pro Lys Glu Glu Arg Phe Ala Gly
    290                 295                 300                 
Arg Pro Thr Gln Arg Val Ser Gly Leu Tyr Gln Arg Leu Glu Ser Lys
305                 310                 315                 320 
Cys Ser Met Gly Phe His Ala Gly Trp Glu Gln Pro His Trp Phe Tyr
                325                 330                 335     
Lys Pro Gly Gln Asp Thr Gln Tyr Arg Pro Ser Phe Arg Arg Thr Asn
            340                 345                 350         
Trp Phe Glu Pro Val Gly Ser Glu Tyr Lys Gln Val Met Gln Arg Val
        355                 360                 365             
Ala Val Thr Asp Leu Ser Pro Phe Gly Lys Phe Asn Ile Lys Gly Gln
    370                 375                 380                 
Asp Ser Ile Arg Leu Leu Asp His Leu Phe Ala Asn Val Ile Pro Lys
385                 390                 395                 400 
Val Gly Phe Thr Asn Ile Ser His Met Leu Thr Pro Lys Gly Arg Val
                405                 410                 415     
Tyr Ala Glu Leu Thr Val Ser His Gln Ser Pro Gly Glu Phe Leu Leu
            420                 425                 430         
Ile Thr Gly Ser Gly Ser Glu Leu His Asp Leu Arg Trp Ile Glu Glu
        435                 440                 445             
Glu Ala Val Lys Gly Gly Tyr Asp Val Glu Ile Lys Asn Ile Thr Asp
    450                 455                 460                 
Glu Leu Gly Val Leu Gly Val Ala Gly Pro Gln Ala Arg Lys Val Leu
465                 470                 475                 480 
Gln Lys Leu Thr Ser Glu Asp Leu Ser Asp Asp Val Phe Lys Phe Leu
                485                 490                 495     
Gln Thr Lys Ser Leu Lys Val Ser Asn Ile Pro Val Thr Ala Ile Arg
            500                 505                 510         
Ile Ser Tyr Thr Gly Glu Leu Gly Trp Glu Leu Tyr His Arg Arg Glu
        515                 520                 525             
Asp Ser Val Ala Leu Tyr Asp Ala Ile Met Asn Ala Gly Gln Glu Glu
    530                 535                 540                 
Gly Ile Asp Asn Phe Gly Thr Tyr Ala Met Asn Ala Leu Arg Leu Glu
545                 550                 555                 560 
Lys Ala Phe Arg Ala Trp Gly Leu Glu Met Asn Cys Asp Thr Asn Pro
                565                 570                 575     
Leu Glu Ala Gly Leu Glu Tyr Phe Val Lys Leu Asn Lys Asp Gln Asn
            580                 585                 590         
Ser Cys Phe Ala His Phe Lys Glu Glu Asn Gly Trp Val Ser Arg Trp
        595                 600                 605             
Ala Ile Arg Pro Tyr
    610             


<210> 6246
<211> 444
<212> PRT
<213> Homo sapiens

<400> 6246
Met Arg Glu Ile Val Leu Thr Gln Ile Gly Gln Cys Gly Asn Gln Ile
 1               5                  10                  15      
Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Ala Ile Asp Ser
            20                  25                  30          
Ala Gly Thr Tyr His Gly Asp Ser His Leu Gln Leu Glu Arg Ile Asn
        35                  40                  45              
Val Tyr Tyr Asn Glu Ala Ser Gly Gly Arg Tyr Val Pro Arg Ala Val
    50                  55                  60                  
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro
65                  70                  75                  80  
Phe Gly Gln Val Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Cys Gly
                85                  90                  95      
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu
            100                 105                 110         
Met Glu Ser Val Met Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp
        115                 120                 125             
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly
    130                 135                 140                 
Ser Gly Met Gly Thr Leu Leu Leu Ser Lys Ile Arg Glu Glu Tyr Pro
145                 150                 155                 160 
Asp Arg Ile Ile Asn Thr Phe Ser Ile Leu Pro Ser Pro Lys Val Ser
                165                 170                 175     
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu
            180                 185                 190         
Ile Glu Asn Ala Asp Glu Thr Phe Cys Ile Asp Asn Glu Ala Leu Tyr
        195                 200                 205             
Asp Ile Cys Ser Lys Thr Leu Lys Leu Pro Thr Pro Thr Tyr Gly Asp
    210                 215                 220                 
Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu
225                 230                 235                 240 
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn
                245                 250                 255     
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro
            260                 265                 270         
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Ala Glu
        275                 280                 285             
Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp
    290                 295                 300                 
Pro Arg His Gly Arg Tyr Leu Thr Ala Ala Ala Ile Phe Arg Gly Arg
305                 310                 315                 320 
Met Pro Met Arg Glu Val Asp Glu Gln Met Phe Asn Ile Gln Asp Lys
                325                 330                 335     
Asn Ser Ser Tyr Phe Ala Asp Trp Leu Pro Asn Asn Val Lys Thr Ala
            340                 345                 350         
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile
        355                 360                 365             
Gly Asn Asn Thr Ala Ile Gln Glu Leu Phe Lys Arg Val Ser Glu Gln
    370                 375                 380                 
Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly
385                 390                 395                 400 
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn
                405                 410                 415     
Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu
            420                 425                 430         
Glu Glu Asp Glu Glu Tyr Ala Glu Glu Glu Val Ala
        435                 440                 


<210> 6247
<211> 454
<212> PRT
<213> Homo sapiens

<400> 6247
Ile Ala Ile Thr Ile Thr Glu Ala Arg Gln Leu Val Gly Glu Asn Ile
 1               5                  10                  15      
Asp Pro Val Val Thr Ile Glu Ile Gly Asp Glu Lys Lys Gln Ser Thr
            20                  25                  30          
Val Lys Glu Gly Thr Asn Ser Pro Phe Tyr Asn Glu Tyr Phe Val Phe
        35                  40                  45              
Asp Phe Ile Gly Pro Gln Val His Leu Phe Asp Lys Ile Ile Lys Ile
    50                  55                  60                  
Ser Val Ser Ile Ala Leu Val Val Ile Val Val Glu Arg Trp Glu Thr
65                  70                  75                  80  
Phe Trp Ala Leu Gly Thr Leu Trp Asp Asn Ser Ala Tyr Leu Ala Gly
                85                  90                  95      
Asn Arg Phe Arg Arg Ala Ser Val Ser Cys Val Leu Ile Gly Ser Phe
            100                 105                 110         
Lys Val Asp Leu Gly Thr Val Tyr Asn Gln Pro Gly His Gln Phe Cys
        115                 120                 125             
Asn Lys Trp Ala Leu Leu Thr Asp Pro Gly Asp Ile Arg Thr Gly Thr
    130                 135                 140                 
Lys Gly Tyr Leu Lys Cys Asp Ile Ser Val Met Gly Lys Gly Asp Val
145                 150                 155                 160 
Leu Lys Thr Ser Pro Lys Thr Ser Asp Thr Glu Glu Pro Ile Glu Lys
                165                 170                 175     
Asn Leu Leu Ile Pro Asn Gly Phe Pro Leu Glu Arg Pro Trp Ala Arg
            180                 185                 190         
Phe Tyr Val Arg Leu Tyr Lys Ala Glu Gly Leu Pro Lys Met Asn Ser
        195                 200                 205             
Ser Ile Met Ala Asn Val Thr Lys Ala Phe Val Gly Asp Ser Lys Asp
    210                 215                 220                 
Leu Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly Gln Met Gly Arg
225                 230                 235                 240 
Thr Thr Val Gln Lys Asn Cys Ala Asp Pro Val Trp His Glu Gln Val
                245                 250                 255     
Ile Phe Lys Glu Met Phe Pro Pro Leu Cys Arg Arg Val Lys Ile Gln
            260                 265                 270         
Val Trp Asp Glu Gly Ser Met Asn Asp Val Ala Leu Ala Thr His Phe
        275                 280                 285             
Ile Asp Leu Lys Lys Ile Ser Asn Glu Gln Asp Gly Asp Lys Gly Phe
    290                 295                 300                 
Leu Pro Thr Phe Gly Pro Ala Trp Ile Asn Leu Tyr Gly Ser Pro Arg
305                 310                 315                 320 
Asn His Ser Leu Met Asp Asp Tyr Gln Glu Met Asn Glu Gly Phe Gly
                325                 330                 335     
Glu Gly Val Ser Phe Arg Gly Arg Ile Leu Val Glu Ile Ala Val Glu
            340                 345                 350         
Ile Leu Ser Gly Arg Ala Gln Glu Ser Lys Phe Ser Lys Ala Leu Lys
        355                 360                 365             
Glu Leu Lys Leu Pro Ser Lys Asp Lys Asp Ser Lys Ser Ser Lys Gly
    370                 375                 380                 
Lys Asp Lys Ala Asp Lys Thr Glu Asp Gly Lys Ser Gln Gln Ala Ser
385                 390                 395                 400 
Asn Lys Thr Asn Ser Thr Glu Val Glu Val Glu Ser Phe Asp Val Pro
                405                 410                 415     
Pro Glu Val Glu Lys Asn Glu Glu Phe Leu Leu Phe Gly Ala Phe Phe
            420                 425                 430         
Glu Ala Thr Met Ile Asp Arg Lys Ile Gly Asp Lys Pro Ile Ser Phe
        435                 440                 445             
Glu Val Ser Ile Gly Lys
    450                 


<210> 6248
<211> 439
<212> PRT
<213> Homo sapiens

<400> 6248
Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu
 1               5                  10                  15      
Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu
            20                  25                  30          
Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile
        35                  40                  45              
Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser
    50                  55                  60                  
Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys
65                  70                  75                  80  
Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys
                85                  90                  95      
Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly
            100                 105                 110         
Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro
        115                 120                 125             
Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala
    130                 135                 140                 
Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp
145                 150                 155                 160 
Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg
                165                 170                 175     
Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys
            180                 185                 190         
Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met
        195                 200                 205             
Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys
    210                 215                 220                 
Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln
225                 230                 235                 240 
Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser
                245                 250                 255     
His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val
            260                 265                 270         
Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala
        275                 280                 285             
Asp Leu Thr Leu Lys Gly Met Val Thr Gly Leu Lys Leu Ser Gln Asp
    290                 295                 300                 
Leu Asp Asp Leu Ala Ile Leu Tyr Leu Ala Thr Val Gln Ala Ile Ala
305                 310                 315                 320 
Leu Gly Thr Arg Phe Ile Ile Glu Ala Met Glu Ala Ala Gly His Ser
                325                 330                 335     
Ile Ser Thr Leu Phe Leu Cys Gly Gly Leu Ser Lys Asn Pro Leu Phe
            340                 345                 350         
Val Gln Met His Ala Asp Ile Thr Gly Met Pro Val Val Leu Ser Gln
        355                 360                 365             
Glu Val Glu Ser Val Leu Val Gly Ala Ala Val Leu Gly Ala Cys Ala
    370                 375                 380                 
Ser Gly Asp Phe Ala Ser Val Gln Glu Ala Met Ala Lys Met Ser Lys
385                 390                 395                 400 
Val Gly Lys Val Val Phe Pro Arg Leu Gln Asp Lys Lys Tyr Tyr Asp
                405                 410                 415     
Lys Lys Tyr Gln Val Phe Leu Lys Leu Val Glu His Gln Lys Glu Tyr
            420                 425                 430         
Leu Ala Ile Met Asn Asp Asp
        435                 


<210> 6249
<211> 246
<212> PRT
<213> Homo sapiens

<400> 6249
Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu
 1               5                  10                  15      
Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu
            20                  25                  30          
Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile
        35                  40                  45              
Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser
    50                  55                  60                  
Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys
65                  70                  75                  80  
Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys
                85                  90                  95      
Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly
            100                 105                 110         
Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro
        115                 120                 125             
Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala
    130                 135                 140                 
Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp
145                 150                 155                 160 
Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg
                165                 170                 175     
Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys
            180                 185                 190         
Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met
        195                 200                 205             
Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys
    210                 215                 220                 
Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln
225                 230                 235                 240 
Val Lys Ala Thr Ala Arg
                245     


<210> 6250
<211> 1593
<212> PRT
<213> Homo sapiens

<400> 6250
Met Ala Ala Ala Ala Val Val Val Pro Ala Glu Trp Ile Lys Asn Trp
 1               5                  10                  15      
Glu Lys Ser Gly Arg Gly Glu Phe Leu His Leu Cys Arg Ile Leu Ser
            20                  25                  30          
Glu Asn Lys Ser His Asp Ser Ser Thr Tyr Arg Asp Phe Gln Gln Ala
        35                  40                  45              
Leu Tyr Glu Leu Ser Tyr His Val Ile Lys Gly Asn Leu Lys His Glu
    50                  55                  60                  
Gln Ala Ser Asn Val Leu Ser Asp Ile Ser Glu Phe Arg Glu Asp Met
65                  70                  75                  80  
Pro Ser Ile Leu Ala Asp Val Phe Cys Ile Leu Asp Ile Glu Thr Asn
                85                  90                  95      
Cys Leu Glu Glu Lys Ser Lys Arg Asp Tyr Phe Thr Gln Leu Val Leu
            100                 105                 110         
Ala Cys Leu Tyr Leu Val Ser Asp Thr Val Leu Lys Glu Arg Leu Asp
        115                 120                 125             
Pro Glu Thr Leu Glu Ser Leu Gly Leu Ile Lys Gln Ser Gln Gln Phe
    130                 135                 140                 
Asn Gln Lys Ser Val Lys Ile Lys Thr Lys Leu Phe Tyr Lys Gln Gln
145                 150                 155                 160 
Lys Phe Asn Leu Leu Arg Glu Glu Asn Glu Gly Tyr Ala Lys Leu Ile
                165                 170                 175     
Ala Glu Leu Gly Gln Asp Leu Ser Gly Ser Ile Thr Ser Asp Leu Ile
            180                 185                 190         
Leu Glu Asn Ile Lys Ser Leu Ile Gly Cys Phe Asn Leu Asp Pro Asn
        195                 200                 205             
Arg Val Leu Asp Val Ile Leu Glu Val Phe Glu Cys Arg Pro Glu His
    210                 215                 220                 
Asp Asp Phe Phe Ile Ser Leu Leu Glu Ser Tyr Met Ser Met Cys Glu
225                 230                 235                 240 
Pro Gln Thr Leu Cys His Ile Leu Gly Phe Lys Phe Lys Phe Tyr Gln
                245                 250                 255     
Glu Pro Asn Gly Glu Thr Pro Ser Ser Leu Tyr Arg Val Ala Ala Val
            260                 265                 270         
Leu Leu Gln Phe Asn Leu Ile Asp Leu Asp Asp Leu Tyr Val His Leu
        275                 280                 285             
Leu Pro Ala Asp Asn Cys Ile Met Asp Glu His Lys Arg Glu Ile Ala
    290                 295                 300                 
Glu Ala Lys Gln Ile Val Arg Lys Leu Thr Met Val Val Leu Ser Ser
305                 310                 315                 320 
Glu Lys Met Asp Glu Arg Glu Lys Glu Lys Glu Lys Glu Glu Glu Lys
                325                 330                 335     
Val Glu Lys Pro Pro Asp Asn Gln Lys Leu Gly Leu Leu Glu Ala Leu
            340                 345                 350         
Leu Lys Ile Gly Asp Trp Gln His Ala Gln Asn Ile Met Asp Gln Met
        355                 360                 365             
Pro Pro Tyr Tyr Ala Ala Ser His Lys Leu Ile Ala Leu Ala Ile Cys
    370                 375                 380                 
Lys Leu Ile His Ile Thr Ile Glu Pro Leu Tyr Arg Arg Val Gly Val
385                 390                 395                 400 
Pro Lys Gly Ala Lys Gly Ser Pro Val Asn Ala Leu Gln Asn Lys Arg
                405                 410                 415     
Ala Pro Lys Gln Ala Glu Ser Phe Glu Asp Leu Arg Arg Asp Val Phe
            420                 425                 430         
Asn Met Phe Cys Tyr Leu Gly Pro His Leu Ser His Asp Pro Ile Leu
        435                 440                 445             
Phe Ala Lys Val Val Arg Ile Gly Lys Ser Phe Met Lys Glu Phe Gln
    450                 455                 460                 
Ser Asp Gly Ser Lys Gln Glu Asp Lys Glu Lys Thr Glu Val Ile Leu
465                 470                 475                 480 
Ser Cys Leu Leu Ser Ile Thr Asp Gln Val Leu Leu Pro Ser Leu Ser
                485                 490                 495     
Leu Met Asp Cys Asn Ala Cys Met Ser Glu Glu Leu Trp Gly Met Phe
            500                 505                 510         
Lys Thr Phe Pro Tyr Gln His Arg Tyr Arg Leu Tyr Gly Gln Trp Lys
        515                 520                 525             
Asn Glu Thr Tyr Asn Ser His Pro Leu Leu Val Lys Val Lys Ala Gln
    530                 535                 540                 
Thr Ile Asp Arg Ala Lys Tyr Ile Met Lys Arg Leu Thr Lys Glu Asn
545                 550                 555                 560 
Val Lys Pro Ser Gly Arg Gln Ile Gly Lys Leu Ser His Ser Asn Pro
                565                 570                 575     
Thr Ile Leu Phe Asp Tyr Ile Leu Ser Gln Ile Gln Lys Tyr Asp Asn
            580                 585                 590         
Leu Ile Thr Pro Val Val Asp Ser Leu Lys Tyr Leu Thr Ser Leu Asn
        595                 600                 605             
Tyr Asp Val Leu Ala Tyr Cys Ile Ile Glu Ala Leu Ala Asn Pro Glu
    610                 615                 620                 
Lys Glu Arg Met Lys His Asp Asp Thr Thr Ile Ser Ser Trp Leu Gln
625                 630                 635                 640 
Ser Leu Ala Ser Phe Cys Gly Ala Val Phe Arg Lys Tyr Pro Ile Asp
                645                 650                 655     
Leu Ala Gly Leu Leu Gln Tyr Val Ala Asn Gln Leu Lys Ala Gly Lys
            660                 665                 670         
Ser Phe Asp Leu Leu Ile Leu Lys Glu Val Val Gln Lys Met Ala Gly
        675                 680                 685             
Ile Glu Ile Thr Glu Glu Met Thr Met Glu Gln Leu Glu Ala Met Thr
    690                 695                 700                 
Gly Gly Glu Gln Leu Lys Ala Glu Gly Gly Tyr Phe Gly Gln Ile Arg
705                 710                 715                 720 
Asn Thr Lys Lys Ser Ser Gln Arg Leu Lys Asp Ala Leu Leu Asp His
                725                 730                 735     
Asp Leu Ala Leu Pro Leu Cys Leu Leu Met Ala Gln Gln Arg Asn Gly
            740                 745                 750         
Val Ile Phe Gln Glu Gly Gly Glu Lys His Leu Lys Leu Val Gly Lys
        755                 760                 765             
Leu Tyr Asp Gln Cys His Asp Thr Leu Val Gln Phe Gly Gly Phe Leu
    770                 775                 780                 
Ala Ser Asn Leu Ser Thr Glu Asp Tyr Ile Lys Arg Val Pro Ser Ile
785                 790                 795                 800 
Asp Val Leu Cys Asn Glu Phe His Thr Pro His Asp Ala Ala Phe Phe
                805                 810                 815     
Leu Ser Arg Pro Met Tyr Ala His His Ile Ser Ser Lys Tyr Asp Glu
            820                 825                 830         
Leu Lys Lys Ser Glu Lys Gly Ser Lys Gln Gln His Lys Val His Lys
        835                 840                 845             
Tyr Ile Thr Ser Cys Glu Met Val Met Ala Pro Val His Glu Ala Val
    850                 855                 860                 
Val Ser Leu His Val Ser Lys Val Trp Asp Asp Ile Ser Pro Gln Phe
865                 870                 875                 880 
Tyr Ala Thr Phe Trp Ser Leu Thr Met Tyr Asp Leu Ala Val Pro His
                885                 890                 895     
Thr Ser Tyr Glu Arg Glu Val Asn Lys Leu Lys Val Gln Met Lys Ala
            900                 905                 910         
Ile Asp Asp Asn Gln Glu Met Pro Pro Asn Lys Lys Lys Lys Glu Lys
        915                 920                 925             
Glu Arg Cys Thr Ala Leu Gln Asp Lys Leu Leu Glu Glu Glu Lys Lys
    930                 935                 940                 
Gln Met Glu His Val Gln Arg Val Leu Gln Arg Leu Lys Leu Glu Lys
945                 950                 955                 960 
Asp Asn Trp Leu Leu Ala Lys Ser Thr Lys Asn Glu Thr Ile Thr Lys
                965                 970                 975     
Phe Leu Gln Leu Cys Ile Phe Pro Arg Cys Ile Phe Ser Ala Ile Asp
            980                 985                 990         
Ala Val Tyr Cys Ala Arg Phe Val Glu Leu Val His Gln Gln Lys Thr
        995                 1000                1005            
Pro Asn Phe Ser Thr Leu Leu Cys Tyr Asp Arg Val Phe Ser Asp Ile
    1010                1015                1020                
Ile Tyr Thr Val Ala Ser Cys Thr Glu Asn Glu Ala Ser Arg Tyr Gly
1025                1030                1035                1040
Arg Phe Leu Cys Cys Met Leu Glu Thr Val Thr Arg Trp His Ser Asp
                1045                1050                1055    
Arg Ala Thr Tyr Glu Lys Glu Cys Gly Asn Tyr Pro Gly Phe Leu Thr
            1060                1065                1070        
Ile Leu Arg Ala Thr Gly Phe Asp Gly Gly Asn Lys Ala Asp Gln Leu
        1075                1080                1085            
Asp Tyr Glu Asn Phe Arg His Val Val His Lys Trp His Tyr Lys Leu
    1090                1095                1100                
Thr Lys Ala Ser Val His Cys Leu Glu Thr Gly Glu Tyr Thr His Ile
1105                1110                1115                1120
Arg Asn Ile Leu Ile Val Leu Thr Lys Ile Leu Pro Trp Tyr Pro Lys
                1125                1130                1135    
Val Leu Asn Leu Gly Gln Ala Leu Glu Arg Arg Val His Lys Ile Cys
            1140                1145                1150        
Gln Glu Glu Lys Glu Lys Arg Pro Asp Leu Tyr Ala Leu Ala Met Gly
        1155                1160                1165            
Tyr Ser Gly Gln Leu Lys Ser Arg Lys Ser Tyr Met Ile Pro Glu Asn
    1170                1175                1180                
Glu Phe His His Lys Asp Pro Pro Pro Arg Asn Ala Val Ala Ser Val
1185                1190                1195                1200
Gln Asn Gly Pro Gly Gly Gly Pro Ser Ser Ser Ser Ile Gly Ser Ala
                1205                1210                1215    
Ser Lys Ser Asp Glu Ser Ser Thr Glu Glu Thr Asp Lys Ser Arg Glu
            1220                1225                1230        
Arg Ser Gln Cys Gly Val Lys Ala Val Asn Lys Ala Ser Ser Thr Thr
        1235                1240                1245            
Pro Lys Gly Asn Ser Ser Asn Gly Asn Ser Gly Ser Asn Ser Asn Lys
    1250                1255                1260                
Ala Val Lys Glu Asn Asp Lys Glu Lys Gly Lys Glu Lys Glu Lys Glu
1265                1270                1275                1280
Lys Lys Glu Lys Thr Pro Ala Thr Thr Pro Glu Ala Arg Val Leu Gly
                1285                1290                1295    
Lys Asp Gly Lys Glu Lys Pro Lys Glu Glu Arg Pro Asn Lys Asp Glu
            1300                1305                1310        
Lys Ala Arg Glu Thr Lys Glu Arg Thr Pro Lys Ser Asp Lys Glu Lys
        1315                1320                1325            
Glu Lys Phe Lys Lys Glu Glu Lys Ala Lys Asp Glu Lys Phe Lys Thr
    1330                1335                1340                
Thr Val Pro Asn Ala Glu Ser Lys Ser Thr Gln Glu Arg Glu Arg Glu
1345                1350                1355                1360
Lys Glu Pro Ser Arg Glu Arg Asp Ile Ala Lys Glu Met Lys Ser Lys
                1365                1370                1375    
Glu Asn Val Lys Gly Gly Glu Lys Thr Pro Val Ser Gly Ser Leu Lys
            1380                1385                1390        
Ser Pro Val Pro Arg Ser Asp Ile Pro Glu Pro Glu Arg Glu Gln Lys
        1395                1400                1405            
Arg Arg Lys Ile Asp Thr His Pro Ser Pro Ser His Ser Ser Thr Val
    1410                1415                1420                
Lys Asp Ser Leu Ile Glu Leu Lys Glu Ser Ser Ala Lys Leu Tyr Ile
1425                1430                1435                1440
Asn His Thr Pro Pro Pro Leu Ser Lys Ser Lys Glu Arg Glu Met Asp
                1445                1450                1455    
Lys Lys Asp Leu Asp Lys Ser Arg Glu Arg Ser Arg Glu Arg Glu Lys
            1460                1465                1470        
Lys Asp Glu Lys Asp Arg Lys Glu Arg Lys Arg Asp His Ser Asn Asn
        1475                1480                1485            
Asp Arg Glu Val Pro Pro Asp Leu Thr Lys Arg Arg Lys Glu Glu Asn
    1490                1495                1500                
Gly Thr Met Gly Val Ser Lys His Lys Ser Glu Ser Pro Cys Glu Ser
1505                1510                1515                1520
Pro Tyr Pro Asn Glu Lys Asp Lys Glu Lys Asn Lys Ser Lys Ser Ser
                1525                1530                1535    
Gly Lys Glu Lys Gly Ser Asp Ser Phe Lys Ser Glu Lys Met Asp Lys
            1540                1545                1550        
Ile Ser Ser Gly Gly Lys Lys Glu Ser Arg His Asp Lys Glu Lys Ile
        1555                1560                1565            
Glu Lys Lys Glu Lys Arg Asp Ser Ser Gly Gly Lys Glu Glu Lys Lys
    1570                1575                1580                
His His Lys Ser Ser Asp Lys His Arg
1585                1590            


<210> 6251
<211> 1314
<212> PRT
<213> Homo sapiens

<400> 6251
Met Phe Val Ser Asp Thr Val Leu Lys Glu Arg Leu Asp Pro Glu Thr
 1               5                  10                  15      
Leu Glu Ser Leu Gly Leu Ile Lys Gln Ser Gln Gln Phe Asn Gln Lys
            20                  25                  30          
Ser Val Lys Ile Lys Thr Lys Leu Phe Tyr Lys Gln Gln Lys Phe Asn
        35                  40                  45              
Leu Leu Arg Glu Glu Asn Glu Gly Tyr Ala Lys Leu Ile Ala Glu Leu
    50                  55                  60                  
Gly Gln Asp Leu Ser Gly Ser Ile Thr Ser Asp Leu Ile Leu Glu Asn
65                  70                  75                  80  
Ile Lys Ser Leu Ile Gly Cys Phe Asn Leu Asp Pro Asn Arg Val Leu
                85                  90                  95      
Asp Val Ile Leu Glu Val Phe Glu Cys Arg Pro Glu His Asp Asp Phe
            100                 105                 110         
Phe Ile Ser Leu Leu Glu Ser Tyr Met Ser Met Cys Glu Pro Gln Thr
        115                 120                 125             
Leu Cys His Ile Leu Gly Phe Lys Phe Lys Phe Tyr Gln Glu Pro Asn
    130                 135                 140                 
Gly Glu Thr Pro Ser Ser Leu Tyr Arg Val Ala Ala Val Leu Leu Gln
145                 150                 155                 160 
Phe Asn Leu Ile Asp Leu Asp Asp Leu Tyr Val His Leu Leu Pro Ala
                165                 170                 175     
Asp Asn Cys Ile Met Asp Glu His Lys Arg Glu Ile Ala Glu Ala Lys
            180                 185                 190         
Gln Ile Val Arg Lys Leu Thr Met Val Val Leu Ser Ser Glu Lys Met
        195                 200                 205             
Asp Glu Arg Glu Lys Glu Lys Glu Lys Glu Glu Glu Lys Val Glu Lys
    210                 215                 220                 
Pro Pro Asp Asn Gln Lys Leu Gly Leu Leu Glu Ala Leu Leu Lys Ile
225                 230                 235                 240 
Gly Asp Trp Gln His Ala Gln Asn Ile Met Asp Gln Met Pro Pro Tyr
                245                 250                 255     
Tyr Ala Ala Ser His Lys Leu Ile Ala Leu Ala Ile Cys Lys Leu Ile
            260                 265                 270         
His Ile Thr Ile Glu Pro Leu Tyr Arg Arg Val Gly Val Pro Lys Gly
        275                 280                 285             
Ala Lys Gly Ser Pro Val Asn Ala Leu Gln Asn Lys Arg Ala Pro Lys
    290                 295                 300                 
Gln Ala Glu Ser Phe Glu Asp Leu Arg Arg Asp Val Phe Asn Met Phe
305                 310                 315                 320 
Cys Tyr Leu Gly Pro His Leu Ser His Asp Pro Ile Leu Phe Ala Lys
                325                 330                 335     
Val Val Arg Ile Gly Lys Ser Phe Met Lys Glu Phe Gln Ser Asp Gly
            340                 345                 350         
Ser Lys Gln Glu Asp Lys Glu Lys Thr Glu Val Ile Leu Ser Cys Leu
        355                 360                 365             
Leu Ser Ile Thr Asp Gln Val Leu Leu Pro Ser Leu Ser Leu Met Asp
    370                 375                 380                 
Cys Asn Ala Cys Met Ser Glu Glu Leu Trp Gly Met Phe Lys Thr Phe
385                 390                 395                 400 
Pro Tyr Gln His Arg Tyr Arg Leu Tyr Gly Gln Trp Lys Asn Glu Thr
                405                 410                 415     
Tyr Asn Ser His Pro Leu Leu Val Lys Val Lys Ala Gln Thr Ile Asp
            420                 425                 430         
Arg Ala Lys Tyr Ile Met Lys Arg Leu Thr Lys Glu Asn Val Lys Pro
        435                 440                 445             
Ser Gly Arg Gln Ile Gly Lys Leu Ser His Ser Asn Pro Thr Ile Leu
    450                 455                 460                 
Phe Asp Tyr Ile Leu Ser Gln Ile Gln Lys Tyr Asp Asn Leu Ile Thr
465                 470                 475                 480 
Pro Val Val Asp Ser Leu Lys Tyr Leu Thr Ser Leu Asn Tyr Asp Val
                485                 490                 495     
Leu Ala Tyr Cys Ile Ile Glu Ala Leu Ala Asn Pro Glu Lys Glu Arg
            500                 505                 510         
Met Lys His Asp Asp Thr Thr Ile Ser Ser Trp Leu Gln Ser Leu Ala
        515                 520                 525             
Ser Phe Cys Gly Ala Val Phe Arg Lys Tyr Pro Ile Asp Leu Ala Gly
    530                 535                 540                 
Leu Leu Gln Tyr Val Ala Asn Gln Leu Lys Ala Gly Lys Ser Phe Asp
545                 550                 555                 560 
Leu Leu Ile Leu Lys Glu Val Val Gln Lys Met Ala Gly Ile Glu Ile
                565                 570                 575     
Thr Glu Glu Met Thr Met Glu Gln Leu Glu Ala Met Thr Gly Gly Glu
            580                 585                 590         
Gln Leu Lys Ala Glu Gly Gly Tyr Phe Gly Gln Ile Arg Asn Thr Lys
        595                 600                 605             
Lys Ser Ser Gln Arg Leu Lys Asp Ala Leu Leu Asp His Asp Leu Ala
    610                 615                 620                 
Leu Pro Leu Cys Leu Leu Met Ala Gln Gln Arg Asn Gly Val Ile Phe
625                 630                 635                 640 
Gln Glu Gly Gly Glu Lys His Leu Lys Leu Val Gly Lys Leu Tyr Asp
                645                 650                 655     
Gln Cys His Asp Thr Leu Val Gln Phe Gly Gly Phe Leu Ala Ser Asn
            660                 665                 670         
Leu Ser Thr Glu Asp Tyr Ile Lys Arg Val Pro Ser Ile Asp Val Leu
        675                 680                 685             
Cys Asn Glu Phe His Thr Pro His Asp Ala Ala Phe Phe Leu Ser Arg
    690                 695                 700                 
Pro Met Tyr Ala His His Ile Ser Ser Lys Tyr Asp Glu Leu Lys Lys
705                 710                 715                 720 
Ser Glu Lys Gly Ser Lys Gln Gln His Lys Val His Lys Tyr Ile Thr
                725                 730                 735     
Ser Cys Glu Met Val Met Ala Pro Val His Glu Ala Val Val Ser Leu
            740                 745                 750         
His Val Ser Lys Val Trp Asp Asp Ile Ser Pro Gln Phe Tyr Ala Thr
        755                 760                 765             
Phe Trp Ser Leu Thr Met Tyr Asp Leu Ala Val Pro His Thr Ser Tyr
    770                 775                 780                 
Glu Arg Glu Val Asn Lys Leu Lys Val Gln Met Lys Ala Ile Asp Asp
785                 790                 795                 800 
Asn Gln Glu Met Pro Pro Asn Lys Lys Lys Lys Glu Lys Glu Arg Cys
                805                 810                 815     
Thr Ala Leu Gln Asp Lys Leu Leu Glu Glu Glu Lys Lys Gln Met Glu
            820                 825                 830         
His Val Gln Arg Val Leu Gln Arg Leu Lys Leu Glu Lys Asp Asn Trp
        835                 840                 845             
Leu Leu Ala Lys Ser Thr Lys Asn Glu Thr Ile Thr Lys Phe Leu Gln
    850                 855                 860                 
Leu Cys Ile Phe Pro Arg Cys Ile Phe Ser Ala Ile Asp Ala Val Tyr
865                 870                 875                 880 
Cys Ala Arg Phe Val Glu Leu Val His Gln Gln Lys Thr Pro Asn Phe
                885                 890                 895     
Ser Thr Leu Leu Cys Tyr Asp Arg Val Phe Ser Asp Ile Ile Tyr Thr
            900                 905                 910         
Val Ala Ser Cys Thr Glu Asn Glu Ala Ser Arg Tyr Gly Arg Phe Leu
        915                 920                 925             
Cys Cys Met Leu Glu Thr Val Thr Arg Trp His Ser Asp Arg Ala Thr
    930                 935                 940                 
Tyr Glu Lys Glu Cys Gly Asn Tyr Pro Gly Phe Leu Thr Ile Leu Arg
945                 950                 955                 960 
Ala Thr Gly Phe Asp Gly Gly Asn Lys Ala Asp Gln Leu Asp Tyr Glu
                965                 970                 975     
Asn Phe Arg His Val Val His Lys Trp His Tyr Lys Leu Thr Lys Ala
            980                 985                 990         
Ser Val His Cys Leu Glu Thr Gly Glu Tyr Thr His Ile Arg Asn Ile
        995                 1000                1005            
Leu Ile Val Leu Thr Lys Ile Leu Pro Trp Tyr Pro Lys Val Leu Asn
    1010                1015                1020                
Leu Gly Gln Ala Leu Glu Arg Arg Val His Lys Ile Cys Gln Glu Glu
1025                1030                1035                1040
Lys Glu Lys Arg Pro Asp Leu Tyr Ala Leu Ala Met Gly Tyr Ser Gly
                1045                1050                1055    
Gln Leu Lys Ser Arg Lys Ser Tyr Met Ile Pro Glu Asn Glu Phe His
            1060                1065                1070        
His Lys Asp Pro Pro Pro Arg Asn Ala Val Ala Ser Val Gln Asn Gly
        1075                1080                1085            
Pro Gly Gly Gly Pro Ser Ser Ser Ser Ile Gly Ser Ala Ser Lys Ser
    1090                1095                1100                
Asp Glu Ser Ser Thr Glu Glu Thr Asp Lys Ser Arg Glu Arg Ser Gln
1105                1110                1115                1120
Cys Gly Val Lys Ala Val Asn Lys Ala Ser Ser Thr Thr Pro Lys Gly
                1125                1130                1135    
Asn Ser Ser Asn Gly Asn Ser Gly Ser Asn Ser Asn Lys Ala Val Lys
            1140                1145                1150        
Glu Asn Asp Lys Glu Lys Gly Lys Glu Lys Glu Lys Glu Lys Lys Glu
        1155                1160                1165            
Lys Thr Pro Ala Thr Thr Pro Glu Ala Arg Val Leu Gly Lys Asp Gly
    1170                1175                1180                
Lys Glu Lys Pro Lys Glu Glu Arg Pro Asn Lys Asp Glu Lys Ala Arg
1185                1190                1195                1200
Glu Thr Lys Glu Arg Thr Pro Lys Ser Asp Lys Glu Lys Glu Lys Phe
                1205                1210                1215    
Lys Lys Glu Glu Lys Ala Lys Asp Glu Lys Phe Lys Thr Thr Val Pro
            1220                1225                1230        
Asn Ala Glu Ser Lys Ser Thr Gln Glu Arg Glu Arg Glu Lys Glu Pro
        1235                1240                1245            
Ser Arg Glu Arg Asp Ile Ala Lys Glu Met Lys Ser Lys Glu Asn Val
    1250                1255                1260                
Lys Gly Gly Glu Lys Thr Pro Val Ser Gly Ser Leu Lys Ser Pro Val
1265                1270                1275                1280
Pro Arg Ser Asp Ile Pro Glu Pro Glu Arg Glu Gln Lys Arg Arg Lys
                1285                1290                1295    
Ile Asp Thr His Pro Ser Pro Ser His Ser Ser Thr Val Lys Val Ser
            1300                1305                1310        
Ile Ala
        


<210> 6252
<211> 855
<212> PRT
<213> Homo sapiens

<400> 6252
Met Ser Phe Val Arg Val Asn Arg Cys Gly Pro Arg Val Gly Val Arg
 1               5                  10                  15      
Lys Thr Pro Lys Val Lys Lys Lys Lys Thr Ser Val Lys Gln Glu Trp
            20                  25                  30          
Asp Asn Thr Val Thr Asp Leu Thr Val His Arg Ala Thr Pro Glu Asp
        35                  40                  45              
Leu Val Arg Arg His Glu Ile His Lys Ser Lys Asn Arg Ala Leu Val
    50                  55                  60                  
His Trp Glu Leu Gln Glu Lys Ala Leu Lys Arg Lys Trp Arg Lys Gln
65                  70                  75                  80  
Lys Pro Glu Thr Leu Asn Leu Glu Lys Arg Arg Leu Ser Ile Met Lys
                85                  90                  95      
Glu Ile Leu Ser Asp Gln Tyr Gln Met Gln Asp Val Leu Glu Lys Ser
            100                 105                 110         
Asp His Leu Ile Ala Ala Ala Lys Glu Leu Phe Pro Arg Arg Arg Thr
        115                 120                 125             
Gly Phe Pro Asn Val Thr Val Ala Pro Asp Ser Ser Gln Gly Pro Ile
    130                 135                 140                 
Val Val Asn Gln Asp Pro Ile Thr Gln Ser Ile Phe Asn Glu Ser Val
145                 150                 155                 160 
Ile Glu Pro Gln Ala Leu Asn Asp Val Asp Gly Glu Glu Glu Gly Thr
                165                 170                 175     
Val Asn Ser Gln Ser Gly Glu Ser Glu Asn Glu Asn Glu Leu Asp Asn
            180                 185                 190         
Ser Leu Asn Ser Gln Ser Asn Thr Asn Thr Asp Arg Phe Leu Gln Gln
        195                 200                 205             
Leu Thr Glu Glu Asn Phe Glu Leu Ile Ser Lys Leu Trp Thr Asp Ile
    210                 215                 220                 
Gln Gln Lys Ile Ala Thr Gln Ser Gln Ile Thr Pro Pro Gly Thr Pro
225                 230                 235                 240 
Ser Ser Ala Leu Ser Ser Gly Glu Gln Arg Ala Ala Leu Asn Ala Thr
                245                 250                 255     
Asn Ala Val Lys Arg Leu Gln Thr Arg Leu Gln Pro Glu Glu Ser Thr
            260                 265                 270         
Glu Thr Leu Asp Ser Ser Tyr Val Val Gly His Val Leu Asn Ser Arg
        275                 280                 285             
Lys Gln Lys Gln Leu Leu Asn Lys Val Lys Arg Lys Pro Asn Leu His
    290                 295                 300                 
Ala Leu Ser Lys Pro Lys Lys Asn Ile Ser Ser Gly Ser Thr Thr Ser
305                 310                 315                 320 
Ala Asp Leu Pro Asn Arg Thr Asn Ser Asn Leu Asp Val Leu Lys His
                325                 330                 335     
Met Ile His Glu Val Glu His Glu Met Glu Glu Tyr Glu Arg Trp Thr
            340                 345                 350         
Gly Arg Glu Val Lys Gly Leu Gln Ser Ser Gln Gly Leu Thr Gly Phe
        355                 360                 365             
Thr Leu Ser Leu Val Ser Ser Leu Cys Arg Leu Val Arg Tyr Leu Lys
    370                 375                 380                 
Glu Ser Glu Ile Gln Leu Arg Lys Glu Val Glu Thr Arg Gln Gln Leu
385                 390                 395                 400 
Glu Gln Val Leu Gly Asp His Arg Glu Leu Ile Asp Ala Leu Thr Ala
                405                 410                 415     
Glu Ile Leu Arg Leu Arg Glu Glu Asn Ala Ala Thr Gln Ala Arg Leu
            420                 425                 430         
Gln Gln Tyr Met Val Thr Thr Asp Glu Gln Leu Ile Ser Leu Thr His
        435                 440                 445             
Ala Ile Lys Asn Cys Pro Val Ile Asn Asn Arg Gln Glu Ile Gln Ala
    450                 455                 460                 
Ser Glu Ser Gly Ala Thr Gly Arg Arg Val Met Asp Ser Pro Glu Arg
465                 470                 475                 480 
Pro Val Val Asn Ala Asn Val Ser Val Pro Leu Met Phe Arg Glu Glu
                485                 490                 495     
Val Ala Glu Phe Pro Gln Glu Glu Leu Pro Val Lys Leu Ser Gln Val
            500                 505                 510         
Pro Asp Pro Pro Asp Asn Met Asn Leu Ala Lys Asn Phe Pro Ala His
        515                 520                 525             
Ile Phe Glu Pro Ala Val Leu Leu Thr Pro Pro Arg Gln Lys Ser Asn
    530                 535                 540                 
Leu Lys Phe Ser Pro Leu Gln Asp Val Leu Arg Arg Thr Val Gln Thr
545                 550                 555                 560 
Arg Pro Ala Pro Arg Leu Pro Pro Thr Val Glu Ile Ile Glu Lys Glu
                565                 570                 575     
Gln Asn Trp Glu Glu Lys Thr Leu Pro Ile Asp Thr Asp Ile Gln Asn
            580                 585                 590         
Ser Ser Glu Glu Asn Arg Leu Phe Thr Gln Arg Trp Arg Val Ser His
        595                 600                 605             
Met Gly Glu Asp Leu Glu Asn Lys Thr Gln Ala Pro Phe Val Asn Leu
    610                 615                 620                 
Ser Gln Pro Leu Cys Asn Ser His Ser Asn Thr Gln Gln Ser Arg Ser
625                 630                 635                 640 
Pro Thr Phe Ser Glu Glu Leu Pro Val Leu Gly Asp Gly Gln Gln Leu
                645                 650                 655     
Arg Thr Asn Glu Ser Leu Ile Gln Arg Lys Asp Ile Met Thr Arg Ile
            660                 665                 670         
Ala Asp Leu Thr Leu Gln Asn Ser Ala Ile Lys Ala His Met Asn Asn
        675                 680                 685             
Ile Ile Glu Pro Arg Gly Glu Gln Gly Asp Gly Leu Arg Glu Leu Asn
    690                 695                 700                 
Lys Gln Glu Ser Ala Ser Asp Met Thr Ser Thr Phe Pro Val Ala Gln
705                 710                 715                 720 
Ser Leu Thr Pro Gly Ser Met Glu Glu Arg Ile Ala Glu Leu Asn Arg
                725                 730                 735     
Gln Ser Met Glu Ala Arg Gly Lys Leu Leu Gln Leu Ile Glu Gln Gln
            740                 745                 750         
Lys Leu Val Gly Leu Asn Leu Ser Pro Pro Met Ser Pro Val Gln Leu
        755                 760                 765             
Pro Leu Arg Ala Trp Thr Glu Gly Ala Lys Arg Thr Ile Glu Val Ser
    770                 775                 780                 
Ile Pro Gly Ala Glu Ala Pro Glu Ser Ser Lys Cys Ser Thr Val Ser
785                 790                 795                 800 
Pro Val Ser Gly Ile Asn Thr Arg Arg Ser Ser Gly Ala Thr Gly Asn
                805                 810                 815     
Ser Cys Ser Pro Leu Asn Ala Thr Ser Gly Ser Gly Arg Phe Thr Pro
            820                 825                 830         
Leu Asn Pro Arg Ala Lys Ile Glu Lys Gln Asn Glu Glu Gly Trp Phe
        835                 840                 845             
Ala Leu Ser Thr His Val Ser
    850                 855 


<210> 6253
<211> 669
<212> PRT
<213> Homo sapiens

<400> 6253
Met Ala Cys Glu Ile Met Pro Leu Gln Ser Ser Gln Glu Asp Glu Arg
 1               5                  10                  15      
Pro Leu Ser Pro Phe Tyr Leu Ser Ala His Val Pro Gln Val Ser Asn
            20                  25                  30          
Val Ser Ala Thr Gly Glu Leu Leu Glu Arg Thr Ile Arg Ser Ala Val
        35                  40                  45              
Glu Gln His Leu Phe Asp Val Asn Asn Ser Gly Gly Gln Ser Ser Glu
    50                  55                  60                  
Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala Thr Ser Ala Arg
65                  70                  75                  80  
Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp Glu Val Arg His Gly Arg
                85                  90                  95      
Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr Pro Ser Gly Phe Asn His
            100                 105                 110         
Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu Val Glu Lys Val His Lys
        115                 120                 125             
Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro Lys Arg Gln Lys
    130                 135                 140                 
Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gln Asp Gly Leu Val
145                 150                 155                 160 
Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu Arg Thr Gly Pro
                165                 170                 175     
Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly Asn Glu Lys Asp
            180                 185                 190         
Gly Gly His Thr Gln His Phe Glu Ser Pro Thr Met Lys Ile Gln Glu
        195                 200                 205             
His Pro Ser Leu Ser Asp Thr Lys Gln Gln Arg Asn Gln Asp Ala Gly
    210                 215                 220                 
Asp Gln Glu Glu Ser Phe Val Ser Glu Val Pro Gln Ser Asp Leu Thr
225                 230                 235                 240 
Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro Ile Pro Ala Phe Ser
                245                 250                 255     
Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp Glu Ala His Leu Ser Pro
            260                 265                 270         
Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu Asp Glu Asp Ser Asp Pro
        275                 280                 285             
Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gln Ser Arg Gln Tyr Leu
    290                 295                 300                 
Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser His Ser Phe Met
305                 310                 315                 320 
Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp Glu Gln Glu Asp
                325                 330                 335     
Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile Gln Ser Leu Lys Lys Lys
            340                 345                 350         
Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys Lys Tyr Arg Pro
        355                 360                 365             
Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu Lys Trp Thr Asn
    370                 375                 380                 
Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys Glu Ser Lys Leu Lys Ile
385                 390                 395                 400 
Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gln Arg Ser Asn Thr Leu
                405                 410                 415     
Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys Glu Asp Glu Lys Lys Gln
            420                 425                 430         
Glu Leu Val Asp Lys Ala Ile Lys Pro Ser Val Glu Ala Thr Leu Glu
        435                 440                 445             
Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg Ala Glu Ser Ser Arg Pro
    450                 455                 460                 
Glu Asp Ile Lys Asp Met Thr Lys Asp Gln Ile Ala Asn Glu Lys Val
465                 470                 475                 480 
Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu Ser Ile His Gly Arg Pro
                485                 490                 495     
Val Thr Lys Asn Glu Arg Gln Val Met Lys Pro Leu Tyr Asp Arg Tyr
            500                 505                 510         
Arg Leu Val Lys Gln Ile Leu Ser Arg Ala Asn Thr Ile Pro Ile Ile
        515                 520                 525             
Glu Glu Glu Glu Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe
    530                 535                 540                 
Met Val Thr Leu Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gln
545                 550                 555                 560 
Phe Glu Asp Asp Ala Asp Gly Phe Ile Ser Pro Met Asp Asp Lys Ile
                565                 570                 575     
Pro Ser Lys Cys Ser Gln Asp Thr Gly Leu Ser Asn Leu His Ala Ala
            580                 585                 590         
Ser Ile Pro Glu Leu Leu Glu His Leu Gln Glu Met Arg Glu Glu Lys
        595                 600                 605             
Lys Arg Ile Arg Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg
    610                 615                 620                 
Gln Asn Gly Arg Asn Val Gln Lys Glu Asp Arg Thr Pro Met Ala Glu
625                 630                 635                 640 
Glu Tyr Ser Glu Tyr Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu
                645                 650                 655     
Val Leu Ile Ser Lys Arg Asp Thr Asp Ser Lys Ser Met
            660                 665                 


<210> 6254
<211> 697
<212> PRT
<213> Homo sapiens

<400> 6254
Met Ala Cys Glu Ile Met Pro Leu Gln Ser Ser Gln Glu Asp Glu Arg
 1               5                  10                  15      
Pro Leu Ser Pro Phe Tyr Leu Ser Ala His Val Pro Gln Val Ser Asn
            20                  25                  30          
Val Ser Ala Thr Gly Glu Leu Leu Glu Arg Thr Ile Arg Ser Ala Val
        35                  40                  45              
Glu Gln His Leu Phe Asp Val Asn Asn Ser Gly Gly Gln Ser Ser Glu
    50                  55                  60                  
Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala Thr Ser Ala Arg
65                  70                  75                  80  
Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp Glu Val Arg His Gly Arg
                85                  90                  95      
Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr Pro Ser Gly Phe Asn His
            100                 105                 110         
Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu Val Glu Lys Val His Lys
        115                 120                 125             
Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro Lys Arg Gln Lys
    130                 135                 140                 
Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gln Asp Gly Leu Val
145                 150                 155                 160 
Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu Arg Thr Gly Pro
                165                 170                 175     
Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly Asn Glu Lys Asp
            180                 185                 190         
Gly Gly His Thr Gln His Phe Glu Ser Pro Thr Met Lys Ile Gln Glu
        195                 200                 205             
His Pro Ser Leu Ser Asp Thr Lys Gln Gln Arg Asn Gln Asp Ala Gly
    210                 215                 220                 
Asp Gln Glu Glu Ser Phe Val Ser Glu Val Pro Gln Ser Asp Leu Thr
225                 230                 235                 240 
Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro Ile Pro Ala Phe Ser
                245                 250                 255     
Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp Glu Ala His Leu Ser Pro
            260                 265                 270         
Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu Asp Glu Asp Ser Asp Pro
        275                 280                 285             
Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gln Ser Arg Gln Tyr Leu
    290                 295                 300                 
Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser His Ser Phe Met
305                 310                 315                 320 
Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp Glu Gln Glu Asp
                325                 330                 335     
Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile Gln Ser Leu Lys Lys Lys
            340                 345                 350         
Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys Lys Tyr Arg Pro
        355                 360                 365             
Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu Lys Trp Thr Asn
    370                 375                 380                 
Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys Glu Ser Lys Leu Lys Ile
385                 390                 395                 400 
Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gln Arg Ser Asn Thr Leu
                405                 410                 415     
Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys Glu Asp Glu Lys Lys Gln
            420                 425                 430         
Glu Leu Val Asp Lys Ala Ile Lys Pro Ser Val Glu Ala Thr Leu Glu
        435                 440                 445             
Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg Ala Glu Ser Ser Arg Pro
    450                 455                 460                 
Glu Asp Ile Lys Asp Met Thr Lys Asp Gln Ile Ala Asn Glu Lys Val
465                 470                 475                 480 
Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu Ser Ile His Gly Arg Pro
                485                 490                 495     
Val Thr Lys Asn Glu Arg Gln Val Met Lys Pro Leu Tyr Asp Arg Tyr
            500                 505                 510         
Arg Leu Val Lys Gln Ile Leu Ser Arg Ala Asn Thr Ile Pro Ile Ile
        515                 520                 525             
Gly Ser Pro Ser Ser Lys Arg Arg Ser Pro Leu Leu Gln Pro Ile Ile
    530                 535                 540                 
Glu Gly Glu Thr Ala Ser Phe Phe Lys Glu Ile Lys Glu Glu Glu Glu
545                 550                 555                 560 
Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe Met Val Thr Leu
                565                 570                 575     
Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gln Phe Glu Asp Asp
            580                 585                 590         
Ala Asp Gly Phe Ile Ser Pro Met Asp Asp Lys Ile Pro Ser Lys Cys
        595                 600                 605             
Ser Gln Asp Thr Gly Leu Ser Asn Leu His Ala Ala Ser Ile Pro Glu
    610                 615                 620                 
Leu Leu Glu His Leu Gln Glu Met Arg Glu Glu Lys Lys Arg Ile Arg
625                 630                 635                 640 
Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg Gln Asn Gly Arg
                645                 650                 655     
Asn Val Gln Lys Glu Asp Arg Thr Pro Met Ala Glu Glu Tyr Ser Glu
            660                 665                 670         
Tyr Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu Val Leu Ile Ser
        675                 680                 685             
Lys Arg Asp Thr Asp Ser Lys Ser Met
    690                 695         


<210> 6255
<211> 309
<212> PRT
<213> Homo sapiens

<400> 6255
Asn Ile Glu Ile Arg Gln Lys Ile His Thr Gly Glu Lys Cys Tyr Lys
 1               5                  10                  15      
Cys Asn Asp Cys Gly Lys Ile Phe Ser His Met Ser Ser Ile Val Tyr
            20                  25                  30          
His His Lys Phe His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys
        35                  40                  45              
Asp Glu Ala Phe Ser Phe Lys Ser Asn Leu Glu Arg His Arg Arg Ile
    50                  55                  60                  
His Thr Gly Glu Lys Pro Tyr Arg Cys Asn Arg Cys Gly Lys Thr Phe
65                  70                  75                  80  
Ser His Thr Ser Ser Leu Thr Cys His His Arg Leu His Thr Gly Glu
                85                  90                  95      
Lys Pro Tyr Lys Cys Glu Glu Cys Asp Glu Thr Phe Arg Tyr Lys Ser
            100                 105                 110         
Asn Leu Glu Arg His Arg Arg Ile His Asn Gly Glu Lys Pro Tyr Lys
        115                 120                 125             
Cys Asn Glu Tyr Gly Lys Thr Phe Ser Gln Lys Ser Cys Leu Thr Arg
    130                 135                 140                 
His His Arg Leu His Thr Gly Asn Lys Ser Tyr Lys Cys Asn Glu Cys
145                 150                 155                 160 
Gly Lys Thr Phe Ser Lys Glu Leu Thr His Ala Ile Ile Asp Val Ile
                165                 170                 175     
Leu Glu Arg Asn Leu Arg Ser Ala Met Ser Val Ala Lys Pro Phe Ile
            180                 185                 190         
Gly Ser Gln Arg Leu Phe Thr Ile Lys Gln Ser Met Ala Glu Gly Asn
        195                 200                 205             
Phe Thr Asn Val Met Ile Val Thr Thr Ser Ser Val Met Leu Gln Leu
    210                 215                 220                 
Leu Gln Ile Ile Gly Glu Ser Ile Ile Lys Arg Asp Leu Thr Ser Val
225                 230                 235                 240 
Ile Asn Val Thr Asn Phe Ser Asp Ile Val His Thr Leu Gln Phe Thr
                245                 250                 255     
Gly Glu Leu Met Leu Glu Arg Asn Leu Thr Asn Val Lys Asn Val Ile
            260                 265                 270         
Lys Leu Ser Asp Ser Asn Gln Thr Leu Lys Val Ile Gly Glu Phe Ile
        275                 280                 285             
Leu Glu Arg Asn Leu Thr Ser Val Met Ser Val Val Arg Cys Ser Val
    290                 295                 300                 
Lys Ile Arg Pro Leu
305                 


<210> 6256
<211> 969
<212> PRT
<213> Homo sapiens

<400> 6256
Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His
 1               5                  10                  15      
Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln
            20                  25                  30          
Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu
        35                  40                  45              
Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly
    50                  55                  60                  
Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys
65                  70                  75                  80  
Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val
                85                  90                  95      
Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His
            100                 105                 110         
Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala
        115                 120                 125             
Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His
    130                 135                 140                 
Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu
145                 150                 155                 160 
Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu
                165                 170                 175     
Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg
            180                 185                 190         
Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met
        195                 200                 205             
Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser
    210                 215                 220                 
Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile
225                 230                 235                 240 
Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met
                245                 250                 255     
Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu
            260                 265                 270         
Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu
        275                 280                 285             
Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr
    290                 295                 300                 
Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys
305                 310                 315                 320 
Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg
                325                 330                 335     
Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro
            340                 345                 350         
Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met
        355                 360                 365             
Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly
    370                 375                 380                 
Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser
385                 390                 395                 400 
Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly
                405                 410                 415     
Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys
            420                 425                 430         
His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp
        435                 440                 445             
Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu
    450                 455                 460                 
Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly
465                 470                 475                 480 
Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly
                485                 490                 495     
Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg
            500                 505                 510         
His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met
        515                 520                 525             
Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly
    530                 535                 540                 
Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val
545                 550                 555                 560 
Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile
                565                 570                 575     
Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile
            580                 585                 590         
Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp
        595                 600                 605             
Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala
    610                 615                 620                 
Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys
625                 630                 635                 640 
Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile
                645                 650                 655     
His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val
            660                 665                 670         
Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr
        675                 680                 685             
Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys
    690                 695                 700                 
Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly
705                 710                 715                 720 
Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala
                725                 730                 735     
Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu
            740                 745                 750         
Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu
        755                 760                 765             
Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln
    770                 775                 780                 
Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser
785                 790                 795                 800 
Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val
                805                 810                 815     
Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn
            820                 825                 830         
Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala
        835                 840                 845             
Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu
    850                 855                 860                 
Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met
865                 870                 875                 880 
Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val
                885                 890                 895     
Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr
            900                 905                 910         
Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser
        915                 920                 925             
Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr
    930                 935                 940                 
Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly
945                 950                 955                 960 
Gln Glu Gly Pro Leu Glu Gly Lys Ile
                965                 


<210> 6257
<211> 393
<212> PRT
<213> Homo sapiens

<400> 6257
Met Lys Arg Thr Arg Asp Glu Val Asp Ala Thr Leu Gln Ile Ala Lys
 1               5                  10                  15      
Leu Asn Ala Ala Glu Leu Leu Pro Ala Val His Cys Leu Gly Phe Gly
            20                  25                  30          
Pro Gly Ala Ser Gly Ala Ala Ala Gly Asp Phe Cys Leu Leu Glu Leu
        35                  40                  45              
Glu Pro Thr Leu Cys Gln Gln Leu Glu Asp Gly His Ser Leu Val Ile
    50                  55                  60                  
Arg Gly Asp Lys Asp Glu Gln Ala Val Leu Cys Ser Lys Asp Lys Thr
65                  70                  75                  80  
Tyr Asp Leu Lys Ile Ala Asp Thr Ser Asn Met Leu Leu Phe Ile Pro
                85                  90                  95      
Gly Cys Lys Thr Pro Asp Gln Leu Lys Lys Glu Asp Ser His Cys Asn
            100                 105                 110         
Ile Ile His Thr Glu Ile Phe Gly Phe Ser Asn Asn Tyr Trp Glu Leu
        115                 120                 125             
Arg Arg Arg Arg Pro Lys Leu Lys Lys Leu Lys Lys Leu Leu Met Glu
    130                 135                 140                 
Asn Pro Tyr Glu Gly Pro Asp Ser Gln Lys Glu Lys Asp Ser Asn Ser
145                 150                 155                 160 
Ser Lys Tyr Thr Thr Glu Asp Leu Leu Asp Gln Ile Gln Ala Ser Glu
                165                 170                 175     
Glu Glu Ile Met Thr Gln Leu Gln Val Leu Asn Ala Cys Lys Ile Gly
            180                 185                 190         
Gly Tyr Trp Arg Ile Leu Glu Phe Asp Tyr Glu Met Lys Leu Leu Asn
        195                 200                 205             
His Val Thr Gln Leu Val Asp Ser Glu Ser Trp Ser Phe Gly Lys Val
    210                 215                 220                 
Pro Leu Asn Thr Cys Leu Gln Glu Leu Gly Pro Leu Glu Pro Glu Glu
225                 230                 235                 240 
Met Ile Glu His Cys Leu Lys Cys Tyr Gly Lys Lys Tyr Val Asp Glu
                245                 250                 255     
Gly Glu Val Tyr Phe Glu Leu Asp Ala Asp Lys Ile Cys Arg Ala Ala
            260                 265                 270         
Ala Arg Met Leu Leu Gln Asn Ala Val Lys Phe Asn Leu Ala Glu Phe
        275                 280                 285             
Gln Glu Val Trp Gln Gln Ser Val Pro Glu Gly Met Val Thr Ser Leu
    290                 295                 300                 
Asp Gln Leu Lys Gly Leu Ala Leu Val Asp Arg His Ser Arg Pro Glu
305                 310                 315                 320 
Ile Ile Phe Leu Leu Lys Val Asp Asp Leu Pro Glu Asp Asn Gln Glu
                325                 330                 335     
Arg Phe Asn Ser Leu Phe Ser Leu Arg Glu Lys Trp Thr Glu Glu Asp
            340                 345                 350         
Ile Ala Pro Tyr Ile Gln Asp Leu Cys Gly Glu Lys Gln Thr Ile Gly
        355                 360                 365             
Ala Leu Leu Thr Lys Tyr Ser His Ser Ser Met Gln Asn Gly Val Lys
    370                 375                 380                 
Val Tyr Asn Ser Arg Arg Pro Ile Ser
385                 390             


<210> 6258
<211> 285
<212> PRT
<213> Homo sapiens

<400> 6258
Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Leu Ser Thr Ser Gly
 1               5                  10                  15      
Pro Arg Ala Phe Ser Ser His Ser Tyr Ser Ser Gly Pro Ser Ala Cys
            20                  25                  30          
Ile Ser Ser Leu Ser Phe Ser Gln Val Gly Ser Ser Ser Phe Arg Gly
        35                  40                  45              
Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr
    50                  55                  60                  
Ala Val Met Val Asn Gln Asn Leu Leu Ser Pro Leu Val Leu Glu Val
65                  70                  75                  80  
Asp Pro Asn Ile Gln Ala Val Cys Thr Gln Glu Lys Glu Pro Ile Lys
                85                  90                  95      
Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu
            100                 105                 110         
Glu Gln Gln Asn Lys Met Pro Glu Thr Lys Trp Ser Leu Leu Gln Gln
        115                 120                 125             
Gln Lys Thr Ala Arg Ser Asn Met Asp Lys Phe Glu Ser Tyr Ile Asn
    130                 135                 140                 
Asn Leu Arg Gln Gln Leu Glu Ile Leu Gly Gln Glu Lys Leu Lys Leu
145                 150                 155                 160 
Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Ser Gly Met Gln Asn
                165                 170                 175     
Met Ser Ile His Thr Lys Thr Thr Ser Gly Tyr Ala Gly Gly Leu Ser
            180                 185                 190         
Ser Ala Tyr Gly Gly Leu Thr Ser Pro Ser Leu Ser Tyr Gly Leu Gly
        195                 200                 205             
Ser Ser Phe Gly Ser Gly Ala Gly Ser Ser Ser Phe Ser Arg Thr Ser
    210                 215                 220                 
Ser Ser Arg Ala Val Val Val Lys Lys Ile Glu Thr Arg Asp Arg Lys
225                 230                 235                 240 
Leu Val Ser Glu Ser Ser Asp Ser Cys Pro Ser Glu Gln Leu Arg Gln
                245                 250                 255     
Pro Leu Pro Ala Cys Pro Phe Cys Ala Ala Pro Glu Pro Gly Arg Glu
            260                 265                 270         
Ala Thr Met Gln Gly Ser Thr Gly Asn Arg Arg Pro Thr
        275                 280                 285 


<210> 6259
<211> 339
<212> PRT
<213> Homo sapiens

<400> 6259
Met Asp Glu Thr Val Ala Glu Phe Ile Lys Arg Thr Ile Leu Lys Ile
 1               5                  10                  15      
Pro Met Asn Glu Leu Thr Thr Ile Leu Lys Ala Trp Asp Phe Leu Ser
            20                  25                  30          
Glu Asn Gln Leu Gln Thr Val Asn Phe Arg Gln Arg Lys Glu Ser Val
        35                  40                  45              
Val Gln His Leu Ile His Leu Cys Glu Glu Lys Arg Ala Ser Ile Ser
    50                  55                  60                  
Asp Ala Ala Leu Leu Asp Ile Ile Tyr Met Gln Phe His Gln His Gln
65                  70                  75                  80  
Lys Val Trp Asp Val Phe Gln Met Ser Lys Gly Pro Gly Glu Asp Val
                85                  90                  95      
Asp Leu Phe Asp Met Lys Gln Phe Lys Asn Ser Phe Lys Lys Ile Leu
            100                 105                 110         
Gln Arg Ala Leu Lys Asn Val Thr Val Ser Phe Arg Glu Thr Glu Glu
        115                 120                 125             
Asn Ala Val Trp Ile Arg Ile Ala Trp Gly Thr Gln Tyr Thr Lys Pro
    130                 135                 140                 
Asn Gln Tyr Lys Pro Thr Tyr Val Val Tyr Tyr Ser Gln Thr Pro Tyr
145                 150                 155                 160 
Ala Phe Thr Ser Ser Ser Met Leu Arg Arg Asn Thr Pro Leu Leu Gly
                165                 170                 175     
Gln Ala Leu Thr Ile Ala Ser Lys His His Gln Ile Val Lys Met Asp
            180                 185                 190         
Leu Arg Ser Arg Tyr Leu Asp Ser Leu Lys Ala Ile Val Phe Lys Gln
        195                 200                 205             
Tyr Asn Gln Thr Phe Glu Thr His Asn Ser Thr Thr Pro Leu Gln Glu
    210                 215                 220                 
Arg Ser Leu Gly Leu Asp Ile Asn Met Asp Ser Arg Ile Ile His Glu
225                 230                 235                 240 
Asn Ile Val Glu Lys Glu Arg Val Gln Arg Ile Thr Gln Glu Thr Phe
                245                 250                 255     
Gly Asp Tyr Pro Gln Pro Gln Leu Glu Phe Ala Gln Tyr Lys Leu Glu
            260                 265                 270         
Thr Lys Phe Lys Ser Gly Leu Asn Gly Ser Ile Leu Ala Glu Arg Glu
        275                 280                 285             
Glu Pro Leu Arg Cys Leu Ile Lys Phe Ser Ser Pro His Leu Leu Glu
    290                 295                 300                 
Ala Leu Lys Ser Leu Ala Pro Ala Gly Ile Ala Asp Ala Pro Leu Ser
305                 310                 315                 320 
Pro Leu Leu Thr Cys Ile Pro Asn Lys Arg Met Asn Tyr Phe Lys Ile
                325                 330                 335     
Arg Asp Lys
            


<210> 6260
<211> 1406
<212> PRT
<213> Homo sapiens

<400> 6260
Met Asp Met Val Glu Asn Ala Asp Ser Leu Gln Ala Gln Glu Arg Lys
 1               5                  10                  15      
Asp Ile Leu Met Lys Tyr Asp Lys Gly His Arg Ala Gly Leu Pro Glu
            20                  25                  30          
Asp Lys Gly Pro Glu Pro Val Gly Ile Asn Ser Ser Ile Asp Arg Phe
        35                  40                  45              
Gly Ile Leu His Glu Thr Glu Leu Pro Pro Val Thr Ala Arg Glu Ala
    50                  55                  60                  
Lys Lys Ile Arg Arg Glu Met Thr Arg Thr Ser Lys Trp Met Glu Met
65                  70                  75                  80  
Leu Gly Glu Trp Glu Thr Tyr Lys His Ser Ser Lys Leu Ile Asp Arg
                85                  90                  95      
Val Tyr Lys Gly Ile Pro Met Asn Ile Arg Gly Pro Val Trp Ser Val
            100                 105                 110         
Leu Leu Asn Ile Gln Glu Ile Lys Leu Lys Asn Pro Gly Arg Tyr Gln
        115                 120                 125             
Ile Met Lys Glu Arg Gly Lys Arg Ser Ser Glu His Ile His His Ile
    130                 135                 140                 
Asp Leu Asp Val Arg Thr Thr Leu Arg Asn His Val Phe Phe Arg Asp
145                 150                 155                 160 
Arg Tyr Gly Ala Lys Gln Arg Glu Leu Phe Tyr Ile Leu Leu Ala Tyr
                165                 170                 175     
Ser Glu Tyr Asn Pro Glu Val Gly Tyr Cys Arg Asp Leu Ser His Ile
            180                 185                 190         
Thr Ala Leu Phe Leu Leu Tyr Leu Pro Glu Glu Asp Ala Phe Trp Ala
        195                 200                 205             
Leu Val Gln Leu Leu Ala Ser Glu Arg His Ser Leu Pro Gly Phe His
    210                 215                 220                 
Ser Pro Asn Gly Gly Thr Val Gln Gly Leu Gln Asp Gln Gln Glu His
225                 230                 235                 240 
Val Val Pro Lys Ser Gln Pro Lys Thr Met Trp His Gln Asp Lys Glu
                245                 250                 255     
Gly Leu Cys Gly Gln Cys Ala Ser Leu Gly Cys Leu Leu Arg Asn Leu
            260                 265                 270         
Ile Asp Gly Ile Ser Leu Gly Leu Thr Leu Arg Leu Trp Asp Val Tyr
        275                 280                 285             
Leu Val Glu Gly Glu Gln Val Leu Met Pro Ile Thr Ser Ile Ala Leu
    290                 295                 300                 
Lys Val Gln Gln Lys Arg Leu Met Lys Thr Ser Arg Cys Gly Leu Trp
305                 310                 315                 320 
Ala Arg Leu Arg Asn Gln Phe Phe Asp Thr Trp Ala Met Asn Asp Asp
                325                 330                 335     
Thr Val Leu Lys His Leu Arg Ala Ser Thr Lys Lys Leu Thr Arg Lys
            340                 345                 350         
Gln Gly Asp Leu Pro Pro Pro Ala Lys Arg Glu Gln Gly Ser Leu Ala
        355                 360                 365             
Pro Arg Pro Val Pro Ala Ser Arg Gly Gly Lys Thr Leu Cys Lys Gly
    370                 375                 380                 
Tyr Arg Gln Ala Pro Pro Gly Pro Pro Ala Gln Phe Gln Arg Pro Ile
385                 390                 395                 400 
Cys Ser Ala Ser Pro Pro Trp Ala Ser Arg Phe Ser Thr Pro Cys Pro
                405                 410                 415     
Gly Gly Ala Val Arg Glu Asp Thr Tyr Pro Val Gly Thr Gln Gly Val
            420                 425                 430         
Pro Ser Leu Ala Leu Ala Gln Gly Gly Pro Gln Gly Ser Trp Arg Phe
        435                 440                 445             
Leu Glu Trp Lys Ser Met Pro Arg Leu Pro Thr Asp Leu Asp Ile Gly
    450                 455                 460                 
Gly Pro Trp Phe Pro His Tyr Asp Phe Glu Trp Ser Cys Trp Val Arg
465                 470                 475                 480 
Ala Ile Ser Gln Glu Asp Gln Leu Ala Thr Cys Trp Gln Ala Glu His
                485                 490                 495     
Cys Gly Glu Val His Asn Lys Asp Met Ser Trp Pro Glu Glu Met Ser
            500                 505                 510         
Phe Thr Ala Asn Ser Ser Lys Ile Asp Arg Gln Lys Val Pro Thr Glu
        515                 520                 525             
Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn
    530                 535                 540                 
Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe
545                 550                 555                 560 
Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly
                565                 570                 575     
Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu
            580                 585                 590         
Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr
        595                 600                 605             
Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser
    610                 615                 620                 
Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn
625                 630                 635                 640 
Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg
                645                 650                 655     
Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg
            660                 665                 670         
Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln
        675                 680                 685             
Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Phe
    690                 695                 700                 
Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu
705                 710                 715                 720 
Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu
                725                 730                 735     
Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg
            740                 745                 750         
Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His
        755                 760                 765             
Asp Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu
    770                 775                 780                 
Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser
785                 790                 795                 800 
Pro Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro
                805                 810                 815     
Ser Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys
            820                 825                 830         
Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly
        835                 840                 845             
Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser
    850                 855                 860                 
Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys
865                 870                 875                 880 
Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro
                885                 890                 895     
Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg
            900                 905                 910         
Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala
        915                 920                 925             
Arg Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp
    930                 935                 940                 
Asn Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys
945                 950                 955                 960 
Asp Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly
                965                 970                 975     
Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr
            980                 985                 990         
Ile Ala Val Asp Trp His Pro Thr Ala Leu His Leu Arg Tyr Gln Thr
        995                 1000                1005            
Ser Gln Glu Arg Val Val Asp Lys His Glu Ser Val Glu Gln Ser Arg
    1010                1015                1020                
Arg Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg Ala Phe
1025                1030                1035                1040
Thr Ser Glu Glu Glu Leu Gly Glu Ser Glu Met Tyr Tyr Cys Ser Lys
                1045                1050                1055    
Cys Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp Arg Leu
            1060                1065                1070        
Pro Pro Phe Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val Asn Asp
        1075                1080                1085            
Gln Trp Ile Lys Ser Gln Lys Ile Val Arg Phe Leu Arg Glu Ser Phe
    1090                1095                1100                
Asp Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys Gln His
1105                1110                1115                1120
Lys Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Lys Pro Arg Ile Leu
                1125                1130                1135    
Ala Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly Lys Glu
            1140                1145                1150        
Asp Met Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn Ile Ser
        1155                1160                1165            
Ser Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly Thr Ser
    1170                1175                1180                
Cys Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg Thr Leu
1185                1190                1195                1200
Gly Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser Lys Asn
                1205                1210                1215    
Lys Pro Ser Ser Ser Lys Lys Asn Leu Asp Ala Ser Lys Glu Asn Gly
            1220                1225                1230        
Ala Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly His Met
        1235                1240                1245            
Arg Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His Glu Val
    1250                1255                1260                
Ala Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly Asn Gly
1265                1270                1275                1280
Cys Gly Asp Gly Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu
                1285                1290                1295    
Asp Ser Thr Asp Asp Gln Arg Glu Asp Thr His Ile Lys Pro Ile Tyr
            1300                1305                1310        
Asn Leu Tyr Ala Ile Ser Cys His Ser Gly Ile Leu Ser Gly Gly His
        1315                1320                1325            
Tyr Ile Thr Tyr Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn
    1330                1335                1340                
Asp Ser Ser Cys Glu Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser
1345                1350                1355                1360
Ala Tyr Ile Leu Phe Tyr Glu Gln Gln Gly Ile Asp Tyr Ala Gln Phe
                1365                1370                1375    
Leu Pro Lys Ile Asp Gly Lys Lys Met Ala Asp Thr Ser Ser Thr Asp
            1380                1385                1390        
Glu Asp Ser Glu Ser Asp Tyr Glu Lys Tyr Ser Met Leu Gln
        1395                1400                1405    


<210> 6261
<211> 262
<212> PRT
<213> Homo sapiens

<400> 6261
Met Ala Val Thr Ala Gln Ala Ala Arg Arg Lys Glu Arg Val Leu Cys
 1               5                  10                  15      
Leu Phe Asp Val Asp Gly Thr Leu Thr Pro Ala Arg Gln Lys Ile Asp
            20                  25                  30          
Pro Glu Val Ala Ala Phe Leu Gln Lys Leu Arg Ser Arg Val Gln Ile
        35                  40                  45              
Gly Val Val Gly Gly Ser Asp Tyr Cys Lys Ile Ala Glu Gln Leu Gly
    50                  55                  60                  
Asp Gly Asp Glu Val Ile Glu Lys Phe Asp Tyr Val Phe Ala Glu Asn
65                  70                  75                  80  
Gly Thr Val Gln Tyr Lys His Gly Arg Leu Leu Ser Lys Gln Thr Ile
                85                  90                  95      
Gln Asn His Leu Gly Glu Glu Leu Leu Gln Asp Leu Ile Asn Phe Cys
            100                 105                 110         
Leu Ser Tyr Met Ala Leu Leu Arg Leu Pro Lys Lys Arg Gly Thr Phe
        115                 120                 125             
Ile Glu Phe Arg Asn Gly Met Leu Asn Ile Ser Pro Ile Gly Arg Ser
    130                 135                 140                 
Cys Thr Leu Glu Glu Arg Ile Glu Phe Ser Glu Leu Asp Lys Lys Glu
145                 150                 155                 160 
Lys Ile Arg Glu Lys Phe Val Glu Ala Leu Lys Thr Glu Phe Ala Gly
                165                 170                 175     
Lys Gly Leu Arg Phe Ser Arg Gly Gly Met Ile Ser Phe Asp Val Phe
            180                 185                 190         
Pro Glu Gly Trp Asp Lys Arg Tyr Cys Leu Asp Ser Leu Asp Gln Asp
        195                 200                 205             
Ser Phe Asp Thr Ile His Phe Phe Gly Asn Glu Thr Ser Pro Gly Gly
    210                 215                 220                 
Asn Asp Phe Glu Ile Phe Ala Asp Pro Arg Thr Val Gly His Ser Val
225                 230                 235                 240 
Val Ser Pro Gln Asp Thr Val Gln Arg Cys Arg Glu Ile Phe Phe Pro
                245                 250                 255     
Glu Thr Ala His Glu Ala
            260         


<210> 6262
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 6262
Met Ala Ser Gln Leu Gln Glu Lys Cys Ile Ala Phe Ile Val Asp Asn
 1               5                  10                  15      
Phe Ser Lys Ile Ile Gln Ser Glu Asn Phe Ala Leu Leu Leu Gln Ser
            20                  25                  30          
Gln Ala Met Ser Ser Thr Ala Asp Leu Leu Asp Thr Ile Leu Lys Ala
        35                  40                  45              
Ile Glu Glu Asn Ile Thr Thr Glu Asn Ser Cys Ser Leu Leu Met Ala
    50                  55                  60                  
Leu Asp Thr Leu Leu Asn Ser Asp Ser Thr Lys Glu Met Gly Phe Thr
65                  70                  75                  80  
Cys Lys Ile Gln Ala Leu Arg Asp Lys Leu Trp Ile Phe Leu Val Gln
                85                  90                  95      
Ser Phe Tyr Ala Val Arg His Thr Glu Ser Trp Lys Leu Met Ser Thr
            100                 105                 110         
Asp Asp Gln Gln Lys Ile Gln Ala Ala Ala Phe Asp Lys Gly Asp Asp
        115                 120                 125             
Arg Arg Leu Gly Lys Lys Pro Ile Phe Ser Ser Ser Gln Gln Arg Lys
    130                 135                 140                 
Gln Val Ser Asp Ser Gly Asp Ile Lys Ile Lys Ser Trp Arg Gly Asn
145                 150                 155                 160 
Asn Lys Lys Glu Cys Trp Ser Tyr Leu Ser Thr Asn Lys Lys Met Lys
                165                 170                 175     
Ser Asp Gly Leu Gly Ala Ser Gly His Ser Ser Ser Thr Asn Arg Asn
            180                 185                 190         
Ser Ile Asn Lys Thr Leu Lys Gln Asp Asp Val Lys Glu Lys Asp Gly
        195                 200                 205             
Thr Lys Ile Ala Ser Lys Ile Thr Lys Glu Leu Lys Thr Gly Gly Lys
    210                 215                 220                 
Asn Val Ser Gly Lys Pro Lys Thr Val Thr Lys Ser Lys Thr Glu Asn
225                 230                 235                 240 
Gly Asp Lys Ala Arg Leu Glu Asn Met Ser Pro Arg Gln Val Val Glu
                245                 250                 255     
Arg Ser Ala Thr Ala Ala Ala Ala Ala Thr Gly Gln Lys Asn Leu Leu
            260                 265                 270         
Asn Gly Lys Gly Val Arg Asn Gln Glu Gly Gln Ile Ser Gly Ala Arg
        275                 280                 285             
Pro Lys Val Leu Thr Gly Asn Leu Asn Val Gln Ala Lys Ala Lys Pro
    290                 295                 300                 
Leu Lys Lys Ala Thr Gly Lys Asp Ser Pro Cys Leu Ser Ile Ala Gly
305                 310                 315                 320 
Pro Ser Ser Arg Ser Thr Asp Ser Ser Met Glu Phe Ser Ile Ser Thr
                325                 330                 335     
Glu Cys Leu Asp Glu Pro Lys Glu Asn Gly Ser Thr Glu Glu Glu Lys
            340                 345                 350         
Pro Ser Gly His Lys Leu Ser Phe Cys Asp Ser Pro Gly Gln Met Met
        355                 360                 365             
Lys Asn Ser Val Asp Ser Val Lys Asn Ser Thr Val Ala Ile Lys Ser
    370                 375                 380                 
Arg Pro Val Ser Arg Val Thr Asn Gly Thr Ser Asn Lys Lys Ser Ile
385                 390                 395                 400 
His Glu Gln Asp Thr Asn Val Asn Asn Ser Val Leu Lys Lys Val Ser
                405                 410                 415     
Gly Lys Gly Cys Ser Glu Pro Val Pro Gln Ala Ile Leu Lys Lys Arg
            420                 425                 430         
Gly Thr Ser Asn Gly Cys Thr Ala Ala Gln Gln Arg Thr Lys Ser Thr
        435                 440                 445             
Pro Ser Asn Leu Thr Lys Thr Gln Gly Ser Gln Gly Glu Ser Pro Asn
    450                 455                 460                 
Ser Val Lys Ser Ser Val Ser Ser Arg Gln Ser Asp Glu Asn Val Ala
465                 470                 475                 480 
Lys Leu Asp His Asn Thr Thr Thr Glu Lys Gln Ala Pro Lys Arg Lys
                485                 490                 495     
Met Val Lys Gln Val His Thr Ala Leu Pro Lys Val Asn Ala Lys Ile
            500                 505                 510         
Val Ala Met Pro Lys Asn Leu Asn Gln Ser Lys Lys Gly Glu Thr Leu
        515                 520                 525             
Asn Asn Lys Asp Ser Lys Gln Lys Met Pro Pro Gly Gln Val Ile Ser
    530                 535                 540                 
Lys Thr Gln Pro Ser Ser Gln Arg Pro Leu Lys His Glu Thr Ser Thr
545                 550                 555                 560 
Val Gln Lys Ser Met Phe His Asp Val Arg Asp Asn Asn Asn Lys Asp
                565                 570                 575     
Ser Val Ser Glu Gln Lys Pro His Lys Pro Leu Ile Asn Leu Ala Ser
            580                 585                 590         
Glu Ile Ser Asp Ala Glu Ala Leu Gln Ser Ser Cys Arg Pro Asp Pro
        595                 600                 605             
Gln Lys Pro Leu Asn Asp Gln Glu Lys Glu Lys Leu Ala Leu Glu Cys
    610                 615                 620                 
Gln Asn Ile Ser Lys Leu Asp Lys Ser Leu Lys His Glu Leu Glu Ser
625                 630                 635                 640 
Lys Gln Ile Cys Leu Asp Lys Ser Glu Thr Lys Phe Pro Asn His Lys
                645                 650                 655     
Glu Thr Asp Asp Cys Asp Ala Ala Asn Ile Cys Cys His Ser Val Gly
            660                 665                 670         
Ser Asp Asn Val Asn Ser Lys Phe Tyr Ser Thr Thr Ala Leu Lys Tyr
        675                 680                 685             
Met Val Ser Asn Pro Asn Glu Asn Ser Leu Asn Ser Asn Pro Val Cys
    690                 695                 700                 
Asp Leu Asp Ser Thr Ser Ala Gly Gln Ile His Leu Ile Ser Asp Arg
705                 710                 715                 720 
Glu Asn Gln Val Gly Arg Lys Asp Thr Asn Lys Gln Ser Ser Ile Lys
                725                 730                 735     
Cys Val Glu Asp Val Ser Leu Cys Asn Pro Glu Arg Thr Asn Gly Thr
            740                 745                 750         
Leu Asn Ser Ala Gln Glu Asp Lys Lys Ser Lys Val Pro Val Glu Gly
        755                 760                 765             
Leu Thr Ile Pro Ser Lys Leu Ser Asp Glu Ser Ala Met Asp Glu Asp
    770                 775                 780                 
Lys His Ala Thr Ala Asp Ser Asp Val Ser Ser Lys Cys Phe Ser Gly
785                 790                 795                 800 
Gln Leu Ser Glu Lys Asn Ser Pro Lys Asn Met Glu Thr Ser Glu Ser
                805                 810                 815     
Pro Glu Ser His Glu Thr Pro Glu Thr Pro Phe Val Gly His Trp Asn
            820                 825                 830         
Leu Ser Thr Gly Val Leu His Gln Arg Glu Ser Pro Glu Ser Asp Thr
        835                 840                 845             
Gly Ser Ala Thr Thr Ser Ser Asp Asp Ile Lys Pro Arg Ser Glu Asp
    850                 855                 860                 
Tyr Asp Ala Gly Gly Ser Gln Asp Asp Asp Gly Ser Asn Asp Arg Gly
865                 870                 875                 880 
Ile Ser Lys Cys Gly Thr Met Leu Cys His Asp Phe Leu Gly Arg Ser
                885                 890                 895     
Ser Ser Asp Thr Ser Thr Pro Glu Glu Leu Lys Ile Tyr Asp Ser Asn
            900                 905                 910         
Leu Arg Ile Glu Val Lys Met Lys Lys Gln Ser Asn Asn Asp Leu Phe
        915                 920                 925             
Gln Val Asn Ser Thr Ser Asp Asp Glu Ile Pro Arg Lys Arg Pro Glu
    930                 935                 940                 
Ile Trp Ser Arg Ser Ala Ile Val His Ser Arg Glu Arg Glu Asn Ile
945                 950                 955                 960 
Pro Arg Gly Ser Val Gln Phe Ala Gln Glu Ile Asp Gln Val Ser Ser
                965                 970                 975     
Ser Ala Asp Glu Thr Glu Asp Glu Arg Ser Glu Ala Glu Asn Val Ala
            980                 985                 990         
Glu Asn Phe Ser Ile Ser Asn Pro Ala Pro Gln Gln Phe Gln Gly Ile
        995                 1000                1005            
Ile Asn Leu Ala Phe Glu Asp Ala Thr Glu Asn Glu Cys Arg Glu Phe
    1010                1015                1020                
Ser Ala Thr Lys Lys Phe Lys Arg Ser Val Leu Leu Ser Val Asp Glu
1025                1030                1035                1040
Cys Glu Glu Leu Gly Ser Asp Glu Gly Glu Val His Thr Pro Phe Gln
                1045                1050                1055    
Ala Ser Val Asp Ser Phe Ser Pro Ser Asp Val Phe Asp Gly Ile Ser
            1060                1065                1070        
His Glu His His Gly Arg Thr Cys Tyr Ser Arg Phe Ser Arg Glu Ser
        1075                1080                1085            
Glu Asp Asn Ile Leu Glu Cys Lys Gln Asn Lys Gly Asn Ser Val Cys
    1090                1095                1100                
Lys Asn Glu Ser Thr Val Leu Asp Leu Ser Ser Ile Asp Ser Ser Arg
1105                1110                1115                1120
Lys Asn Lys Gln Ser Val Ser Ala Thr Glu Lys Lys Asn Thr Ile Asp
                1125                1130                1135    
Val Leu Ser Ser Arg Ser Arg Gln Leu Leu Arg Glu Asp Lys Lys Val
            1140                1145                1150        
Asn Asn Gly Ser Asn Val Glu Asn Asp Ile Gln Gln Arg Ser Lys Phe
        1155                1160                1165            
Leu Asp Ser Asp Val Lys Ser Gln Glu Arg Pro Cys His Leu Asp Leu
    1170                1175                1180                
His Gln Arg Glu Pro Asn Ser Asp Ile Pro Lys Asn Ser Ser Thr Lys
1185                1190                1195                1200
Ser Leu Asp Ser Phe Arg Ser Gln Val Leu Pro Gln Glu Gly Pro Val
                1205                1210                1215    
Lys Glu Ser His Ser Thr Thr Thr Glu Lys Ala Asn Ile Ala Leu Ser
            1220                1225                1230        
Ala Gly Asp Ile Asp Asp Cys Asp Thr Leu Ala Gln Thr Arg Met Tyr
        1235                1240                1245            
Asp His Arg Pro Ser Lys Thr Leu Ser Pro Ile Tyr Glu Met Asp Val
    1250                1255                1260                
Ile Glu Ala Phe Glu Gln Lys Val Glu Ser Glu Thr His Val Thr Asp
1265                1270                1275                1280
Met Asp Phe Glu Asp Asp Gln His Phe Ala Lys Gln Asp Trp Thr Leu
                1285                1290                1295    
Leu Lys Gln Leu Leu Ser Glu Gln Asp Ser Asn Leu Asp Val Thr Asn
            1300                1305                1310        
Ser Val Pro Glu Asp Leu Ser Leu Ala Gln Tyr Leu Ile Asn Gln Thr
        1315                1320                1325            
Leu Leu Leu Ala Arg Asp Ser Ser Lys Pro Gln Gly Ile Thr His Ile
    1330                1335                1340                
Asp Thr Leu Asn Arg Trp Ser Glu Leu Thr Ser Pro Leu Asp Ser Ser
1345                1350                1355                1360
Ala Ser Ile Thr Met Ala Ser Phe Ser Ser Glu Asp Cys Ser Pro Gln
                1365                1370                1375    
Gly Glu Trp Thr Ile Leu Glu Leu Glu Thr Gln His
            1380                1385            


<210> 6263
<211> 701
<212> PRT
<213> Homo sapiens

<400> 6263
Met Glu Glu Asp Thr Asp Tyr Arg Ile Arg Phe Ser Ser Leu Cys Phe
 1               5                  10                  15      
Phe Asn Asp His Val Gly Phe His Gly Thr Ile Lys Ser Ser Pro Ser
            20                  25                  30          
Asp Phe Ile Val Ile Glu Ile Asp Glu Gln Gly Gln Leu Val Asn Lys
        35                  40                  45              
Thr Ile Asp Glu Pro Ile Phe Lys Ile Ser Glu Ile Gln Leu Glu Pro
    50                  55                  60                  
Asn Asn Phe Pro Lys Lys Pro Lys Leu Asp Leu Gln Asn Leu Ser Leu
65                  70                  75                  80  
Glu Asp Gly Arg Asn Gln Glu Val His Thr Leu Ile Lys Tyr Thr Asp
                85                  90                  95      
Gly Asp Gln Asn His Gln Ser Gly Ser Glu Lys Glu Asp Thr Ile Val
            100                 105                 110         
Asp Gly Thr Ser Lys Cys Glu Glu Lys Ala Asp Val Leu Ser Ser Phe
        115                 120                 125             
Leu Asp Glu Lys Thr His Glu Leu Leu Asn Asn Phe Ala Cys Asp Val
    130                 135                 140                 
Arg Glu Lys Trp Leu Ser Lys Thr Glu Leu Ile Gly Leu Pro Pro Glu
145                 150                 155                 160 
Phe Ser Ile Gly Arg Ile Leu Asp Lys Asn Gln Arg Ala Ser Leu His
                165                 170                 175     
Ser Ala Ile Arg Gln Lys Phe Pro Phe Leu Val Thr Val Gly Lys Asn
            180                 185                 190         
Ser Glu Ile Val Val Lys Pro Asn Leu Glu Tyr Lys Glu Leu Cys His
        195                 200                 205             
Leu Val Ser Glu Glu Glu Ala Phe Asp Phe Phe Lys Tyr Leu Asp Ala
    210                 215                 220                 
Lys Lys Glu Asn Ser Lys Phe Thr Phe Lys Pro Asp Thr Asn Lys Asp
225                 230                 235                 240 
His Arg Lys Ala Val His His Phe Val Asn Lys Lys Phe Gly Asn Leu
                245                 250                 255     
Val Glu Thr Lys Ser Phe Ser Lys Met Asn Cys Ser Ala Gly Asn Pro
            260                 265                 270         
Asn Val Val Val Thr Val Arg Phe Arg Glu Lys Ala His Lys Arg Gly
        275                 280                 285             
Lys Arg Pro Leu Ser Glu Cys Gln Glu Gly Lys Val Ile Tyr Thr Ala
    290                 295                 300                 
Phe Thr Leu Arg Lys Glu Asn Leu Glu Met Phe Glu Ala Ile Gly Phe
305                 310                 315                 320 
Leu Ala Ile Lys Leu Gly Val Ile Pro Ser Asp Phe Ser Tyr Ala Gly
                325                 330                 335     
Leu Lys Asp Lys Lys Ala Ile Thr Tyr Gln Ala Met Val Val Arg Lys
            340                 345                 350         
Val Thr Pro Glu Arg Leu Lys Asn Ile Glu Lys Glu Ile Glu Lys Lys
        355                 360                 365             
Arg Met Asn Val Phe Asn Ile Arg Ser Val Asp Asp Ser Leu Arg Leu
    370                 375                 380                 
Gly Gln Leu Lys Gly Asn His Phe Asp Ile Val Ile Arg Asn Leu Lys
385                 390                 395                 400 
Lys Gln Ile Asn Asp Ser Ala Asn Leu Arg Glu Arg Ile Met Glu Ala
                405                 410                 415     
Ile Glu Asn Val Lys Lys Lys Gly Phe Val Asn Tyr Tyr Gly Pro Gln
            420                 425                 430         
Arg Phe Gly Lys Gly Arg Lys Val His Thr Asp Gln Ile Gly Leu Ala
        435                 440                 445             
Leu Leu Lys Asn Glu Met Met Lys Ala Ile Lys Leu Phe Leu Thr Pro
    450                 455                 460                 
Glu Asp Leu Asp Asp Pro Val Asn Arg Ala Lys Lys Tyr Phe Leu Gln
465                 470                 475                 480 
Thr Glu Asp Ala Lys Gly Thr Leu Ser Leu Met Pro Glu Phe Lys Val
                485                 490                 495     
Arg Glu Arg Ala Leu Leu Glu Ala Leu His Arg Phe Gly Met Thr Glu
            500                 505                 510         
Glu Gly Cys Ile Gln Ala Trp Phe Ser Leu Pro His Ser Met Arg Ile
        515                 520                 525             
Phe Tyr Val His Ala Tyr Thr Ser Lys Ile Trp Asn Glu Ala Val Ser
    530                 535                 540                 
Tyr Arg Leu Glu Thr Tyr Gly Ala Arg Val Val Gln Gly Asp Leu Val
545                 550                 555                 560 
Cys Leu Asp Glu Asp Ile Asp Asp Glu Asn Phe Pro Asn Ser Lys Ile
                565                 570                 575     
His Leu Val Thr Glu Glu Glu Gly Ser Ala Asn Met Tyr Ala Ile His
            580                 585                 590         
Gln Val Val Leu Pro Val Leu Gly Tyr Asn Ile Gln Tyr Pro Lys Asn
        595                 600                 605             
Lys Val Gly Gln Trp Tyr His Asp Ile Leu Ser Arg Asp Gly Leu Gln
    610                 615                 620                 
Thr Cys Arg Phe Lys Val Pro Thr Leu Lys Leu Asn Ile Pro Gly Cys
625                 630                 635                 640 
Tyr Arg Gln Ile Leu Lys His Pro Cys Asn Leu Ser Tyr Gln Leu Met
                645                 650                 655     
Glu Asp His Asp Ile Asp Val Lys Thr Lys Gly Ser His Ile Asp Glu
            660                 665                 670         
Thr Ala Leu Ser Leu Leu Ile Ser Phe Asp Leu Asp Ala Ser Cys Tyr
        675                 680                 685             
Ala Thr Val Cys Leu Lys Glu Ile Met Lys His Asp Val
    690                 695                 700     


<210> 6264
<211> 643
<212> PRT
<213> Homo sapiens

<400> 6264
Met Asp Asp Ile Ala Asp Arg Met Arg Met Asp Ala Gly Glu Val Thr
 1               5                  10                  15      
Leu Val Asn His Asn Ser Val Phe Lys Thr His Leu Leu Pro Gln Thr
            20                  25                  30          
Gly Phe Pro Glu Asp Gln Leu Ser Leu Ser Asp Gln Gln Ile Leu Ser
        35                  40                  45              
Ser Arg Gln Gly His Leu Asp Arg Ser Phe Thr Cys Ser Thr Arg Ser
    50                  55                  60                  
Ala Ala Tyr Asn Pro Ser Tyr Tyr Ser Asp Asn Pro Ser Ser Asp Ser
65                  70                  75                  80  
Phe Leu Gly Ser Gly Asp Leu Arg Thr Phe Gly Gln Ser Ala Asn Gly
                85                  90                  95      
Gln Trp Arg Asn Ser Thr Pro Ser Ser Ser Ser Ser Leu Gln Lys Ser
            100                 105                 110         
Arg Asn Ser Arg Ser Leu Tyr Leu Glu Thr Arg Lys Thr Ser Ser Gly
        115                 120                 125             
Leu Ser Asn Ser Phe Ala Gly Lys Ser Asn His His Cys His Val Ser
    130                 135                 140                 
Ala Tyr Glu Lys Ser Phe Pro Ile Lys Pro Val Pro Ser Pro Ser Trp
145                 150                 155                 160 
Ser Gly Ser Cys Arg Arg Ser Leu Leu Ser Pro Lys Lys Thr Gln Arg
                165                 170                 175     
Arg His Val Ser Thr Ala Glu Glu Thr Val Gln Glu Glu Glu Arg Glu
            180                 185                 190         
Ile Tyr Arg Gln Leu Leu Gln Met Val Thr Gly Lys Gln Phe Thr Ile
        195                 200                 205             
Ala Lys Pro Thr Thr His Phe Pro Leu His Leu Ser Arg Cys Leu Ser
    210                 215                 220                 
Ser Ser Lys Asn Thr Leu Lys Asp Ser Leu Phe Lys Asn Gly Asn Ser
225                 230                 235                 240 
Cys Ala Ser Gln Ile Ile Gly Ser Asp Thr Ser Ser Ser Gly Ser Ala
                245                 250                 255     
Ser Ile Leu Thr Asn Gln Glu Gln Leu Ser His Ser Val Tyr Ser Leu
            260                 265                 270         
Ser Ser Tyr Thr Pro Asp Val Ala Phe Gly Ser Lys Asp Ser Gly Thr
        275                 280                 285             
Leu His His Pro His His His His Ser Val Pro His Gln Pro Asp Asn
    290                 295                 300                 
Leu Ala Ala Ser Asn Thr Gln Ser Glu Gly Ser Asp Ser Val Ile Leu
305                 310                 315                 320 
Leu Lys Val Lys Asp Ser Gln Thr Pro Thr Pro Ser Ser Thr Phe Phe
                325                 330                 335     
Gln Ala Glu Leu Trp Ile Lys Glu Leu Thr Ser Val Tyr Asp Ser Arg
            340                 345                 350         
Ala Arg Glu Arg Leu Arg Gln Ile Glu Glu Gln Lys Ala Leu Ala Leu
        355                 360                 365             
Gln Leu Gln Asn Gln Arg Leu Gln Glu Arg Glu His Ser Val His Asp
    370                 375                 380                 
Ser Val Glu Leu His Leu Arg Val Pro Leu Glu Lys Glu Ile Pro Val
385                 390                 395                 400 
Thr Val Val Gln Glu Thr Gln Lys Lys Gly His Lys Leu Thr Asp Ser
                405                 410                 415     
Glu Asp Glu Phe Pro Glu Ile Thr Glu Glu Met Glu Lys Glu Ile Lys
            420                 425                 430         
Asn Val Phe Arg Asn Gly Asn Gln Asp Glu Val Leu Ser Glu Ala Phe
        435                 440                 445             
Arg Leu Thr Ile Thr Arg Lys Asp Ile Gln Thr Leu Asn His Leu Asn
    450                 455                 460                 
Trp Leu Asn Asp Glu Ile Ile Asn Phe Tyr Met Asn Met Leu Met Glu
465                 470                 475                 480 
Arg Ser Lys Glu Lys Gly Leu Pro Ser Val His Ala Phe Asn Thr Phe
                485                 490                 495     
Phe Phe Thr Lys Leu Lys Thr Ala Gly Tyr Gln Ala Val Lys Arg Trp
            500                 505                 510         
Thr Lys Lys Val Asp Val Phe Ser Val Asp Ile Leu Leu Val Pro Ile
        515                 520                 525             
His Leu Gly Val His Trp Cys Leu Ala Val Val Asp Phe Arg Lys Lys
    530                 535                 540                 
Asn Ile Thr Tyr Tyr Asp Ser Met Gly Gly Ile Asn Asn Glu Ala Cys
545                 550                 555                 560 
Arg Ile Leu Leu Gln Tyr Leu Lys Gln Glu Ser Ile Asp Lys Lys Arg
                565                 570                 575     
Lys Glu Phe Asp Thr Asn Gly Trp Gln Leu Phe Ser Lys Lys Ser Gln
            580                 585                 590         
Ile Pro Gln Gln Met Asn Gly Ser Asp Cys Gly Met Phe Ala Cys Lys
        595                 600                 605             
Tyr Ala Asp Cys Ile Thr Lys Asp Arg Pro Ile Asn Phe Thr Gln Gln
    610                 615                 620                 
His Met Pro Tyr Phe Arg Lys Arg Met Val Trp Glu Ile Leu His Arg
625                 630                 635                 640 
Lys Leu Leu
            


<210> 6265
<211> 646
<212> PRT
<213> Homo sapiens

<400> 6265
Met Ser Thr Ala Pro Ser Leu Ser Ala Leu Arg Ser Ser Lys His Ser
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Asp Pro Ala Trp
            20                  25                  30          
Thr Ser Ala Leu Ser Gly Asn Ser Ser Gly Pro Gly Pro Gly Ser Ser
        35                  40                  45              
Pro Ala Gly Ser Thr Lys Pro Phe Val His Ala Val Pro Pro Ser Asp
    50                  55                  60                  
Pro Leu Arg Gln Ala Asn Arg Leu Pro Ile Lys Val Leu Lys Met Leu
65                  70                  75                  80  
Thr Ala Arg Thr Gly His Ile Leu His Pro Glu Tyr Leu Gln Pro Leu
                85                  90                  95      
Pro Ser Thr Pro Val Ser Pro Ile Glu Leu Asp Ala Lys Lys Ser Pro
            100                 105                 110         
Leu Ala Leu Leu Ala Gln Thr Cys Ser Gln Ile Gly Lys Pro Asp Pro
        115                 120                 125             
Ser Pro Ser Ser Lys Leu Ser Ser Val Ala Ser Asn Gly Gly Gly Ala
    130                 135                 140                 
Gly Gly Ala Gly Gly Gly Ala Ala Gly Asp Lys Asp Thr Lys Ser Gly
145                 150                 155                 160 
Pro Leu Lys Leu Ser Asp Ile Gly Val Glu Asp Lys Ser Ser Phe Lys
                165                 170                 175     
Pro Tyr Ser Lys Pro Gly Ser Asp Lys Lys Glu Pro Gly Gly Gly Gly
            180                 185                 190         
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Ser Ser Glu
        195                 200                 205             
Lys Ser Gly Phe Arg Val Pro Ser Ala Thr Cys Gln Pro Phe Thr Pro
    210                 215                 220                 
Arg Thr Gly Ser Pro Ser Ser Ser Ala Ser Ala Cys Ser Pro Gly Gly
225                 230                 235                 240 
Met Leu Ser Ser Ala Gly Gly Ala Pro Glu Gly Lys Asp Asp Lys Lys
                245                 250                 255     
Asp Thr Asp Val Gly Gly Gly Gly Lys Gly Thr Gly Gly Ala Ser Ala
            260                 265                 270         
Glu Gly Gly Pro Thr Gly Leu Ala His Gly Arg Ile Ser Cys Gly Gly
        275                 280                 285             
Gly Ile Asn Val Asp Val Asn Gln His Pro Asp Gly Gly Pro Gly Gly
    290                 295                 300                 
Lys Ala Leu Gly Ser Asp Cys Gly Gly Ser Ser Gly Ser Ser Ser Gly
305                 310                 315                 320 
Ser Gly Pro Ser Ala Pro Thr Ser Ser Ser Val Leu Gly Ser Gly Leu
                325                 330                 335     
Val Ala Pro Val Ser Pro Tyr Lys Pro Gly Gln Thr Val Phe Pro Leu
            340                 345                 350         
Pro Pro Ala Gly Met Thr Tyr Pro Gly Ser Leu Ala Gly Ala Tyr Ala
        355                 360                 365             
Gly Tyr Pro Pro Gln Phe Leu Pro His Gly Val Ala Leu Asp Pro Thr
    370                 375                 380                 
Lys Pro Gly Ser Leu Val Gly Ala Gln Leu Ala Ala Ala Ala Ala Gly
385                 390                 395                 400 
Ser Leu Gly Cys Ser Lys Pro Ala Gly Ser Ser Pro Leu Ala Gly Ala
                405                 410                 415     
Ser Pro Pro Ser Val Met Thr Ala Ser Leu Cys Arg Asp Pro Tyr Cys
            420                 425                 430         
Leu Ser Tyr His Cys Ala Ser His Leu Ala Gly Ala Ala Ala Ala Ser
        435                 440                 445             
Ala Ser Cys Ala His Asp Pro Ala Ala Ala Ala Ala Ala Leu Lys Ser
    450                 455                 460                 
Gly Tyr Pro Leu Val Tyr Pro Thr His Pro Leu His Gly Val His Ser
465                 470                 475                 480 
Ser Leu Thr Ala Ala Ala Ala Ala Gly Ala Thr Pro Pro Ser Leu Ala
                485                 490                 495     
Gly His Pro Leu Tyr Pro Tyr Gly Phe Met Leu Pro Asn Asp Pro Leu
            500                 505                 510         
Pro His Ile Cys Asn Trp Val Ser Ala Asn Gly Pro Cys Asp Lys Arg
        515                 520                 525             
Phe Ala Thr Ser Glu Glu Leu Leu Ser His Leu Arg Thr His Thr Ala
    530                 535                 540                 
Phe Pro Gly Thr Asp Lys Leu Leu Ser Gly Tyr Pro Ser Ser Ser Ser
545                 550                 555                 560 
Leu Ala Ser Ala Ala Ala Ala Ala Met Ala Cys His Met His Ile Pro
                565                 570                 575     
Thr Ser Gly Ala Pro Gly Ser Pro Gly Thr Leu Ala Leu Arg Ser Pro
            580                 585                 590         
His His Ala Leu Gly Leu Ser Ser Arg Tyr His Pro Tyr Ser Lys Ser
        595                 600                 605             
Pro Leu Pro Thr Pro Gly Ala Pro Val Pro Val Pro Ala Ala Thr Gly
    610                 615                 620                 
Pro Tyr Tyr Ser Pro Tyr Ala Leu Tyr Gly Gln Arg Leu Thr Thr Ala
625                 630                 635                 640 
Ser Ala Leu Gly Tyr Gln
                645     


<210> 6266
<211> 283
<212> PRT
<213> Homo sapiens

<400> 6266
Met Ser Thr Ala Pro Ser Leu Ser Ala Leu Arg Ser Ser Lys His Ser
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Asp Pro Ala Trp
            20                  25                  30          
Thr Ser Ala Leu Ser Gly Asn Ser Ser Gly Pro Gly Pro Gly Ser Ser
        35                  40                  45              
Pro Ala Gly Ser Thr Lys Pro Phe Val His Ala Val Pro Pro Ser Asp
    50                  55                  60                  
Pro Leu Arg Gln Ala Asn Arg Leu Pro Ile Lys Val Leu Lys Met Leu
65                  70                  75                  80  
Thr Ala Arg Thr Gly His Ile Leu His Pro Glu Tyr Leu Gln Pro Leu
                85                  90                  95      
Pro Ser Thr Pro Val Ser Pro Ile Glu Leu Asp Ala Lys Lys Ser Pro
            100                 105                 110         
Leu Ala Leu Leu Ala Gln Thr Cys Ser Gln Ile Gly Lys Pro Asp Pro
        115                 120                 125             
Ser Pro Ser Leu Ala Gly His Pro Leu Tyr Pro Tyr Gly Phe Met Leu
    130                 135                 140                 
Pro Asn Asp Pro Leu Pro His Ile Cys Asn Trp Val Ser Ala Asn Gly
145                 150                 155                 160 
Pro Cys Asp Lys Arg Phe Ala Thr Ser Glu Glu Leu Leu Ser His Leu
                165                 170                 175     
Arg Thr His Thr Ala Phe Pro Gly Thr Asp Lys Leu Leu Ser Gly Tyr
            180                 185                 190         
Pro Ser Ser Ser Ser Leu Ala Ser Ala Ala Ala Ala Ala Met Ala Cys
        195                 200                 205             
His Met His Ile Pro Thr Ser Gly Ala Pro Gly Ser Pro Gly Thr Leu
    210                 215                 220                 
Ala Leu Arg Ser Pro His His Ala Leu Gly Leu Ser Ser Arg Tyr His
225                 230                 235                 240 
Pro Tyr Ser Lys Ser Pro Leu Pro Thr Pro Gly Ala Pro Val Pro Val
                245                 250                 255     
Pro Ala Ala Thr Gly Pro Tyr Tyr Ser Pro Tyr Ala Leu Tyr Gly Gln
            260                 265                 270         
Arg Leu Thr Thr Ala Ser Ala Leu Gly Tyr Gln
        275                 280             


<210> 6267
<211> 1188
<212> PRT
<213> Homo sapiens

<400> 6267
Met Ser Leu Leu Asn Pro Val Leu Leu Pro Pro Lys Val Lys Ala Tyr
 1               5                  10                  15      
Leu Ser Gln Gly Glu Arg Phe Ile Lys Trp Asp Asp Glu Thr Thr Val
            20                  25                  30          
Ala Ser Pro Val Ile Leu Arg Val Asp Pro Lys Gly Tyr Tyr Leu Tyr
        35                  40                  45              
Trp Thr Tyr Gln Ser Lys Glu Met Glu Phe Leu Asp Ile Thr Ser Ile
    50                  55                  60                  
Arg Asp Thr Arg Phe Gly Lys Phe Ala Lys Met Pro Lys Ser Gln Lys
65                  70                  75                  80  
Leu Arg Asp Val Phe Asn Met Asp Phe Pro Asp Asn Ser Phe Leu Leu
                85                  90                  95      
Lys Thr Leu Thr Val Val Ser Gly Pro Asp Met Val Asp Leu Thr Phe
            100                 105                 110         
His Asn Phe Val Ser Tyr Lys Glu Asn Val Gly Lys Ala Trp Ala Glu
        115                 120                 125             
Asp Val Leu Ala Leu Val Lys His Pro Leu Thr Ala Asn Ala Ser Arg
    130                 135                 140                 
Ser Thr Phe Leu Asp Lys Ile Leu Val Lys Leu Lys Met Gln Leu Asn
145                 150                 155                 160 
Ser Glu Gly Lys Ile Pro Val Lys Asn Phe Phe Gln Met Phe Pro Ala
                165                 170                 175     
Asp Arg Lys Arg Val Glu Ala Ala Leu Ser Ala Cys His Leu Pro Lys
            180                 185                 190         
Gly Lys Asn Asp Ala Ile Asn Pro Glu Asp Phe Pro Glu Pro Val Tyr
        195                 200                 205             
Lys Ser Phe Leu Met Ser Leu Cys Pro Arg Pro Glu Ile Asp Glu Ile
    210                 215                 220                 
Phe Thr Ser Tyr His Ala Lys Ala Lys Pro Tyr Met Thr Lys Glu His
225                 230                 235                 240 
Leu Thr Lys Phe Ile Asn Gln Lys Gln Arg Asp Ser Arg Leu Asn Ser
                245                 250                 255     
Leu Leu Phe Pro Pro Ala Arg Pro Asp Gln Val Gln Gly Leu Ile Asp
            260                 265                 270         
Lys Tyr Glu Pro Ser Gly Ile Asn Ala Gln Arg Gly Gln Leu Ser Pro
        275                 280                 285             
Glu Gly Met Val Trp Phe Leu Cys Gly Pro Glu Asn Ser Val Leu Ala
    290                 295                 300                 
Gln Asp Lys Leu Leu Leu His His Asp Met Thr Gln Pro Leu Asn His
305                 310                 315                 320 
Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu Thr Ala Gly Gln Phe
                325                 330                 335     
Ser Gly Leu Ser Ser Ala Glu Met Tyr Arg Gln Val Leu Leu Ser Gly
            340                 345                 350         
Cys Arg Cys Val Glu Leu Asp Cys Trp Lys Gly Lys Pro Pro Asp Glu
        355                 360                 365             
Glu Pro Ile Ile Thr His Gly Phe Thr Met Thr Thr Asp Ile Phe Phe
    370                 375                 380                 
Lys Glu Ala Ile Glu Ala Ile Ala Glu Ser Ala Phe Lys Thr Ser Pro
385                 390                 395                 400 
Tyr Pro Ile Ile Leu Ser Phe Glu Asn His Val Asp Ser Pro Arg Gln
                405                 410                 415     
Gln Ala Lys Met Ala Glu Tyr Cys Arg Thr Ile Phe Gly Asp Met Leu
            420                 425                 430         
Leu Thr Glu Pro Leu Glu Lys Phe Pro Leu Lys Pro Gly Val Pro Leu
        435                 440                 445             
Pro Ser Pro Glu Asp Leu Arg Gly Lys Ile Leu Ile Lys Asn Lys Lys
    450                 455                 460                 
Asn Gln Phe Ser Gly Pro Thr Ser Ser Ser Lys Asp Thr Gly Gly Glu
465                 470                 475                 480 
Ala Glu Gly Ser Ser Pro Pro Ser Ala Pro Ala Val Trp Ala Gly Glu
                485                 490                 495     
Glu Gly Thr Glu Leu Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Glu
            500                 505                 510         
Glu Ser Gly Asn Leu Asp Glu Glu Glu Ile Lys Lys Met Gln Ser Asp
        515                 520                 525             
Glu Gly Thr Ala Gly Leu Glu Val Thr Ala Tyr Glu Glu Met Ser Ser
    530                 535                 540                 
Leu Val Asn Tyr Ile Gln Pro Thr Lys Phe Val Ser Phe Glu Phe Ser
545                 550                 555                 560 
Ala Gln Lys Asn Arg Ser Tyr Val Ile Ser Ser Phe Thr Glu Leu Lys
                565                 570                 575     
Ala Tyr Asp Leu Leu Ser Lys Ala Ser Val Gln Phe Val Asp Tyr Asn
            580                 585                 590         
Lys Arg Gln Met Ser Arg Ile Tyr Pro Lys Gly Thr Arg Met Asp Ser
        595                 600                 605             
Ser Asn Tyr Met Pro Gln Met Phe Trp Asn Ala Gly Cys Gln Met Val
    610                 615                 620                 
Ala Leu Asn Phe Gln Thr Met Asp Leu Pro Met Gln Gln Asn Met Ala
625                 630                 635                 640 
Val Phe Glu Phe Asn Gly Gln Ser Gly Tyr Leu Leu Lys His Glu Phe
                645                 650                 655     
Met Arg Arg Pro Asp Lys Gln Phe Asn Pro Phe Ser Val Asp Arg Ile
            660                 665                 670         
Asp Val Val Val Ala Thr Thr Leu Ser Ile Thr Ala Arg Pro Trp Gly
        675                 680                 685             
Thr Gln Val Ile Ser Gly Gln Phe Leu Ser Glu Arg Ser Val Arg Thr
    690                 695                 700                 
Tyr Val Glu Val Glu Leu Phe Gly Leu Pro Gly Asp Pro Lys Arg Arg
705                 710                 715                 720 
Tyr Arg Thr Lys Leu Ser Pro Ser Thr Asn Ser Ile Asn Pro Val Trp
                725                 730                 735     
Lys Glu Glu Pro Phe Val Phe Glu Lys Ile Leu Met Pro Glu Leu Ala
            740                 745                 750         
Ser Leu Arg Val Ala Val Met Glu Glu Gly Asn Lys Phe Leu Gly His
        755                 760                 765             
Arg Ile Ile Pro Ile Asn Ala Leu Asn Ser Gly Tyr His His Leu Cys
    770                 775                 780                 
Leu His Ser Glu Ser Asn Met Pro Leu Thr Met Pro Ala Leu Phe Ile
785                 790                 795                 800 
Phe Leu Glu Met Lys Asp Tyr Ile Pro Gly Ala Trp Ala Asp Leu Thr
                805                 810                 815     
Val Ala Leu Ala Asn Pro Ile Lys Phe Phe Ser Ala His Asp Thr Lys
            820                 825                 830         
Ser Val Lys Leu Lys Glu Ala Met Gly Gly Leu Pro Glu Lys Pro Phe
        835                 840                 845             
Pro Leu Ala Ser Pro Val Ala Ser Gln Val Asn Gly Ala Leu Ala Pro
    850                 855                 860                 
Thr Ser Asn Gly Ser Pro Ala Ala Arg Ala Gly Ala Arg Glu Glu Ala
865                 870                 875                 880 
Met Lys Glu Ala Ala Glu Pro Arg Thr Ala Ser Leu Glu Glu Leu Arg
                885                 890                 895     
Glu Leu Lys Gly Val Val Lys Leu Gln Arg Arg His Glu Lys Glu Leu
            900                 905                 910         
Arg Glu Leu Glu Arg Arg Gly Ala Arg Arg Trp Glu Glu Leu Leu Gln
        915                 920                 925             
Arg Gly Ala Ala Gln Leu Ala Glu Leu Gly Pro Pro Gly Val Gly Gly
    930                 935                 940                 
Val Gly Ala Cys Lys Leu Gly Pro Gly Lys Gly Ser Arg Lys Lys Arg
945                 950                 955                 960 
Ser Leu Pro Arg Glu Glu Ser Ala Gly Ala Ala Pro Gly Glu Gly Pro
                965                 970                 975     
Glu Gly Val Asp Gly Arg Val Arg Glu Leu Lys Asp Arg Leu Glu Leu
            980                 985                 990         
Glu Leu Leu Arg Gln Gly Glu Glu Gln Tyr Glu Cys Val Leu Lys Arg
        995                 1000                1005            
Lys Glu Gln His Val Ala Glu Gln Ile Ser Lys Met Met Glu Leu Ala
    1010                1015                1020                
Arg Glu Lys Gln Ala Ala Glu Leu Lys Ala Leu Lys Glu Thr Ser Glu
1025                1030                1035                1040
Asn Asp Thr Lys Glu Met Lys Lys Lys Leu Glu Thr Lys Arg Leu Glu
                1045                1050                1055    
Arg Ile Gln Gly Met Thr Lys Val Thr Thr Asp Lys Met Ala Gln Glu
            1060                1065                1070        
Arg Leu Lys Arg Glu Ile Asn Asn Ser His Ile Gln Glu Val Val Gln
        1075                1080                1085            
Val Ile Lys Gln Met Thr Glu Asn Leu Glu Arg His Gln Glu Lys Leu
    1090                1095                1100                
Glu Glu Lys Gln Ala Ala Cys Leu Glu Gln Ile Arg Glu Met Glu Lys
1105                1110                1115                1120
Gln Phe Gln Lys Glu Ala Leu Ala Glu Tyr Glu Ala Arg Met Lys Gly
                1125                1130                1135    
Leu Glu Ala Glu Val Lys Glu Ser Val Arg Ala Cys Leu Arg Thr Cys
            1140                1145                1150        
Phe Pro Ser Glu Ala Lys Asp Lys Pro Glu Arg Ala Cys Glu Cys Pro
        1155                1160                1165            
Pro Glu Leu Cys Glu Gln Asp Pro Leu Ile Ala Lys Ala Asp Ala Gln
    1170                1175                1180                
Glu Ser Arg Leu
1185            


<210> 6268
<211> 1302
<212> PRT
<213> Homo sapiens

<400> 6268
Met Ala Cys Ser Ile Leu Glu Gly Cys Arg Arg Glu Val Arg Arg Glu
 1               5                  10                  15      
Thr Trp Lys Pro Gly Pro Gly Ser Glu Arg Cys Gln Arg Gly Arg Ser
            20                  25                  30          
Cys Gly Ala Arg Glu Glu Glu Val Glu Pro Gly Thr Ala Arg Pro Pro
        35                  40                  45              
Pro Ala Ala Ser Ala Met Asp Ala Ser Leu Glu Lys Asn Lys Gly Val
    50                  55                  60                  
Ile Pro Glu Gly Leu Gly Ser Arg Pro Thr Val Leu Val Val Asp Glu
65                  70                  75                  80  
Leu Glu Glu Glu Glu Val Glu Glu Gly Asp Glu Gly Gly Gln Ala Glu
                85                  90                  95      
Pro Glu Glu Glu Gly Gln Pro Gly Val Leu Leu Ser His Val Leu Ile
            100                 105                 110         
Met Gly Gln Asp Gly Leu Glu Val Gln Arg Val Pro Gln Val Leu Gln
        115                 120                 125             
Val Gly Leu Ala Leu Gly Ile Arg Gln His Gly Gln Val Asp Met Val
    130                 135                 140                 
Val Leu Val Ala Asp Ala Met Gln Cys Ile Ala Val Leu Gln His Val
145                 150                 155                 160 
Gly Val Gly Leu Glu Leu Glu Val Val Leu Cys Glu Leu Gln Pro Pro
                165                 170                 175     
Glu Ala Glu His His Ala Leu Gln Asp Ala Trp Gly Thr His Leu His
            180                 185                 190         
Gln Pro Leu Ala Ala Thr Leu Leu Glu Gly Gln Pro Pro Gln Val Arg
        195                 200                 205             
Glu Leu Gln Asp Leu Leu Asp Gly Gly Gln Gln Pro Arg Pro Gln Val
    210                 215                 220                 
Leu Gly Val His Gly Gly Val Pro Ala Glu Ala Val Ile Phe Ile Val
225                 230                 235                 240 
Glu Arg Arg Leu His Leu Val Ser Leu Pro Val Ala Gln Gly Gly Ala
                245                 250                 255     
Glu Gln Arg Gly Trp Arg Ala Gly Glu His Val Ile Glu Arg Gln Val
            260                 265                 270         
His Gly Glu Ala Arg Arg Pro Val Gly Val Ser Asp Leu His Phe His
        275                 280                 285             
Ser Trp Ala Glu Glu Leu Ser Pro Glu Glu Leu Val Val Leu Lys Gln
    290                 295                 300                 
Leu Arg Arg Trp His Leu Gln Glu Leu Gln His Phe Leu Pro Cys Gln
305                 310                 315                 320 
Val Leu Gln Arg Leu Glu Leu Leu Gly Cys Phe Ala Phe Gly His Leu
                325                 330                 335     
Gly Asp Asn Gly Ala Arg Asp Val His His Pro Gln His Arg Leu Ile
            340                 345                 350         
Gln Leu Arg Leu Gly Ser His Leu Glu Ala Val His Gln Leu Leu Gly
        355                 360                 365             
Gly His His His Gln Leu Gln Ala Thr His Ala Ala Gln Gln Pro Leu
    370                 375                 380                 
Pro Gln Gln Gln His Arg Leu Ser Ser Phe Ser Gln Arg Ala Gln Arg
385                 390                 395                 400 
Ala Gln Leu His Glu Gly His Lys Val Arg Arg His Gly Gly Leu Pro
                405                 410                 415     
Leu Pro Gly Ser His Pro Gln Pro Ile Gly Ser His Val Gln Gly Gln
            420                 425                 430         
Glu Ala Val Gly His Gln Gly Arg His Ser Arg Ala Gln Arg Tyr Arg
        435                 440                 445             
Leu Ala Ala Leu Pro Gln Ala Ala Pro Gly Ala Gly Gly Arg Leu Gln
    450                 455                 460                 
Ala Gly Arg Arg Leu Gly Gly Ala Arg Leu Thr Pro Gly Pro Gly Lys
465                 470                 475                 480 
Gln Ile Ala Asp Pro Thr Leu Ala Glu Met Gly Lys Asn Leu Lys Glu
                485                 490                 495     
Ala Val Lys Met Leu Glu Asp Ser Gln Arg Arg Thr Glu Glu Glu Asn
            500                 505                 510         
Gly Lys Lys Leu Ile Ser Gly Asp Ile Pro Gly Pro Leu Gln Gly Ser
        515                 520                 525             
Gly Gln Asp Met Val Ser Ile Leu Gln Leu Val Gln Asn Leu Met His
    530                 535                 540                 
Gly Asp Glu Asp Glu Glu Pro Gln Ser Pro Arg Ile Gln Asn Ile Gly
545                 550                 555                 560 
Glu Gln Gly His Met Ala Leu Leu Gly His Ser Leu Gly Ala Tyr Ile
                565                 570                 575     
Ser Thr Leu Asp Lys Glu Lys Leu Arg Lys Leu Thr Thr Arg Ile Leu
            580                 585                 590         
Ser Asp Thr Thr Leu Trp Leu Cys Arg Ile Phe Arg Tyr Glu Asn Gly
        595                 600                 605             
Cys Ala Tyr Phe His Glu Glu Glu Arg Glu Gly Leu Ala Lys Ile Cys
    610                 615                 620                 
Arg Leu Ala Ile His Ser Arg Tyr Glu Asp Phe Val Val Asp Gly Phe
625                 630                 635                 640 
Asn Val Leu Tyr Asn Lys Lys Pro Val Ile Tyr Leu Ser Ala Ala Ala
                645                 650                 655     
Arg Pro Gly Leu Gly Gln Tyr Leu Cys Asn Gln Leu Gly Leu Pro Phe
            660                 665                 670         
Pro Cys Leu Cys Arg Val Pro Cys Asn Thr Val Phe Gly Ser Gln His
        675                 680                 685             
Gln Met Asp Val Ala Phe Leu Glu Lys Leu Ile Lys Asp Asp Ile Glu
    690                 695                 700                 
Arg Gly Arg Leu Pro Leu Leu Leu Val Ala Asn Ala Gly Thr Ala Ala
705                 710                 715                 720 
Val Gly His Thr Asp Lys Ile Gly Arg Leu Lys Glu Leu Cys Glu Gln
                725                 730                 735     
Tyr Gly Ile Trp Leu His Val Glu Gly Val Asn Leu Ala Thr Leu Ala
            740                 745                 750         
Leu Gly Tyr Val Ser Ser Ser Val Leu Ala Ala Ala Lys Cys Asp Ser
        755                 760                 765             
Met Thr Met Thr Pro Gly Pro Trp Leu Gly Leu Pro Ala Val Pro Ala
    770                 775                 780                 
Val Thr Leu Tyr Lys His Asp Asp Pro Ala Leu Thr Leu Val Ala Gly
785                 790                 795                 800 
Leu Thr Ser Asn Lys Pro Thr Asp Lys Leu Arg Ala Leu Pro Leu Trp
                805                 810                 815     
Leu Ser Leu Gln Tyr Leu Gly Leu Asp Gly Phe Val Glu Arg Ile Lys
            820                 825                 830         
His Ala Cys Gln Leu Val Glu Asp Glu Leu Ser Ser Pro Val Val Val
        835                 840                 845             
Phe Arg Phe Phe Gln Glu Leu Pro Gly Ser Asp Pro Val Phe Lys Ala
    850                 855                 860                 
Val Pro Val Pro Asn Met Thr Pro Ser Gly Val Gly Arg Glu Arg His
865                 870                 875                 880 
Ser Cys Asp Ala Leu Asn Arg Trp Leu Gly Glu Gln Leu Lys Gln Leu
                885                 890                 895     
Val Pro Ala Ser Gly Leu Thr Val Met Asp Leu Glu Ala Glu Gly Thr
            900                 905                 910         
Cys Leu Arg Phe Ser Pro Leu Met Thr Ala Ala Gly Thr Arg Gly Glu
        915                 920                 925             
Asp Val Asp Gln Leu Val Ala Cys Ile Glu Ser Lys Leu Pro Val Leu
    930                 935                 940                 
Cys Cys Thr Leu Gln Leu Arg Glu Glu Phe Lys Gln Glu Val Glu Ala
945                 950                 955                 960 
Thr Ala Gly Leu Leu Tyr Val Asp Asp Pro Asn Trp Ser Gly Ile Gly
                965                 970                 975     
Val Val Arg Tyr Glu His Ala Asn Asp Asp Lys Ser Ser Leu Lys Ser
            980                 985                 990         
Asp Pro Glu Gly Glu Asn Ile His Ala Gly Leu Leu Lys Lys Leu Asn
        995                 1000                1005            
Glu Leu Glu Ser Asp Leu Thr Phe Lys Ile Gly Pro Glu Tyr Lys Ser
    1010                1015                1020                
Met Lys Ser Cys Leu Tyr Val Gly Met Ala Ser Asp Asn Val Asp Ala
1025                1030                1035                1040
Ala Glu Leu Val Glu Thr Ile Ala Ala Thr Ala Arg Glu Ile Glu Glu
                1045                1050                1055    
Asn Ser Arg Leu Leu Glu Asn Met Thr Glu Val Val Arg Lys Gly Ile
            1060                1065                1070        
Gln Glu Ala Gln Val Glu Leu Gln Lys Ala Ser Glu Glu Arg Leu Leu
        1075                1080                1085            
Glu Glu Gly Val Leu Arg Gln Ile Pro Val Val Gly Ser Val Leu Asn
    1090                1095                1100                
Trp Phe Ser Pro Val Gln Ala Leu Gln Lys Gly Arg Thr Phe Asn Leu
1105                1110                1115                1120
Thr Ala Gly Asn Asp Asp Ser Ile Val Met Lys Ala Lys Asp Asn Leu
                1125                1130                1135    
Ile Ser Asn Leu Pro Ser Leu Ser Leu Gln Gln Lys Gly Thr His Phe
            1140                1145                1150        
Leu Trp Leu Gln Tyr Val Ser Leu Leu Gly Leu Ala Pro Trp Val Cys
        1155                1160                1165            
Leu Arg His Thr Ala Gly Gly Cys Trp Arg Tyr Trp Pro Cys Ser Leu
    1170                1175                1180                
Glu Ser Thr Glu Pro Ile Tyr Val Tyr Lys Ala Gln Gly Ala Gly Val
1185                1190                1195                1200
Thr Leu Pro Pro Thr Pro Ser Gly Ser Arg Thr Lys Gln Arg Leu Pro
                1205                1210                1215    
Gly Gln Lys Pro Phe Lys Arg Ser Leu Arg Gly Ser Asp Ala Leu Ser
            1220                1225                1230        
Glu Thr Ser Ser Val Ser His Ile Glu Asp Leu Glu Lys Val Glu Arg
        1235                1240                1245            
Leu Ser Ser Gly Pro Glu Gln Ile Thr Leu Glu Ala Ser Ser Thr Glu
    1250                1255                1260                
Gly His Pro Gly Ala Pro Ser Pro Gln His Thr Asp Gln Thr Glu Ala
1265                1270                1275                1280
Phe Gln Lys Gly Val Pro His Pro Glu Asp Asp His Ser Gln Val Glu
                1285                1290                1295    
Gly Pro Glu Ser Leu Arg
            1300        


<210> 6269
<211> 122
<212> PRT
<213> Homo sapiens

<400> 6269
Met Glu Met Cys Thr Lys Gly Leu Gly Ala Gln Thr Gly Val Leu Arg
 1               5                  10                  15      
Met Lys Gly Val Asn Leu Ser Cys Val Arg Thr Cys Met Val Val Ala
            20                  25                  30          
Glu Glu Arg Pro Arg Ile Ala Leu Thr Gln Ser Phe Ser Lys Leu Phe
        35                  40                  45              
Lys Asp Leu Gly Leu Pro Ala Arg Ala Val Ser Thr Thr Phe Gly Cys
    50                  55                  60                  
Arg Val Asn Val Ala Ile Cys Leu Gln Val Arg Cys Leu Gly Pro Ala
65                  70                  75                  80  
Val Leu Glu Ser Trp Leu Leu Ala Ala Trp Arg Pro Ser Phe Pro Val
                85                  90                  95      
Val Asn Val Pro Phe Cys Ser Arg Leu Ile Tyr Phe Ser Phe Ser Gly
            100                 105                 110         
Pro Leu Ile Ser His Phe His Val Thr Phe
        115                 120         


<210> 6270
<211> 1571
<212> PRT
<213> Homo sapiens

<400> 6270
Met Ala Asp Arg Gly Cys Pro Leu Glu Ala Ala Pro Leu Pro Ala Glu
 1               5                  10                  15      
Val Arg Glu Ser Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp
            20                  25                  30          
Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ala Lys Leu Leu Ala Arg
        35                  40                  45              
Tyr Ile Pro Leu Ile Gln Gly Ile Asp Pro Ser Leu Gln Ala Glu Asn
    50                  55                  60                  
Arg Ile Pro Gly Pro Ser Gln Thr Thr Ala Ala Ala Pro Lys Gln Gln
65                  70                  75                  80  
Lys Ser Arg Pro Thr Ala Ser Arg Asp Glu Arg Phe Arg Ser Asp Val
                85                  90                  95      
His Thr Glu Ala Val Gln Ala Ala Leu Ala Lys Tyr Lys Glu Arg Lys
            100                 105                 110         
Met Pro Met Pro Ser Lys Arg Arg Ser Val Leu Val His Ser Ser Val
        115                 120                 125             
Glu Thr Tyr Thr Pro Pro Asp Thr Ser Ser Ala Ser Glu Asp Glu Gly
    130                 135                 140                 
Ser Leu Arg Arg Pro Gly Arg Leu Thr Ser Thr Pro Leu Gln Ser His
145                 150                 155                 160 
Ser Ser Val Glu Pro Trp Leu Asp Arg Val Ile Gln Gly Ser Ser Thr
                165                 170                 175     
Ser Ser Ser Ala Ser Ser Thr Ser Ser His Pro Gly Gly Arg Pro Thr
            180                 185                 190         
Thr Ala Pro Ser Ala Ala Ala Thr Pro Gly Ala Ala Ala Thr Thr Ala
        195                 200                 205             
Leu Ala Gly Leu Glu Ala His Thr His Ile Asp Leu His Ser Ala Pro
    210                 215                 220                 
Pro Asp Val Thr Thr Gly Leu Val Glu His Ser Tyr Phe Glu Arg Pro
225                 230                 235                 240 
Gln Val Ala Ser Val Arg Ser Val Pro Arg Gly Cys Ser Gly Ser Met
                245                 250                 255     
Leu Glu Thr Ala Asp Gly Val Pro Val Asn Ser Arg Val Ser Ser Lys
            260                 265                 270         
Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro Leu
        275                 280                 285             
Lys Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln Gln
    290                 295                 300                 
Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ser Glu Thr Ser Val Leu
305                 310                 315                 320 
Arg Gly Glu Pro Leu Thr Ala Gly Val Pro Arg Pro Pro Ser Leu Leu
                325                 330                 335     
Ala Thr Leu Gln Arg Trp Gly Thr Thr Gln Pro Lys Ser Pro Cys Leu
            340                 345                 350         
Thr Ala Leu Asp Thr Thr Gly Lys Ala Val Tyr Thr Leu Thr Tyr Gly
        355                 360                 365             
Lys Leu Trp Ser Arg Ser Leu Lys Leu Ala Tyr Thr Leu Leu Asn Lys
    370                 375                 380                 
Leu Thr Ser Lys Asn Glu Pro Leu Leu Lys Pro Gly Asp Arg Val Ala
385                 390                 395                 400 
Leu Val Phe Pro Asn Ser Asp Pro Val Met Phe Met Val Ala Phe Tyr
                405                 410                 415     
Gly Cys Leu Leu Ala Glu Leu Val Pro Val Pro Ile Glu Val Pro Leu
            420                 425                 430         
Thr Arg Lys Asp Ala Gly Ser Gln Gln Val Gly Phe Leu Leu Gly Ser
        435                 440                 445             
Cys Gly Val Phe Leu Ala Leu Thr Thr Asp Ala Cys Gln Lys Gly Leu
    450                 455                 460                 
Pro Lys Ala Gln Thr Gly Glu Val Ala Ala Phe Lys Gly Trp Pro Pro
465                 470                 475                 480 
Leu Ser Trp Leu Val Ile Asp Gly Lys His Leu Ala Lys Pro Pro Lys
                485                 490                 495     
Asp Trp His Pro Leu Ala Gln Asp Thr Gly Thr Gly Thr Ala Tyr Ile
            500                 505                 510         
Glu Tyr Lys Thr Ser Lys Glu Gly Ser Thr Val Gly Val Thr Val Ser
        515                 520                 525             
His Ala Ser Leu Leu Ala Gln Cys Arg Ala Leu Thr Gln Ala Cys Gly
    530                 535                 540                 
Tyr Ser Glu Ala Glu Thr Leu Thr Asn Val Leu Asp Phe Lys Arg Asp
545                 550                 555                 560 
Ala Gly Leu Trp His Gly Val Leu Thr Ser Val Met Asn Arg Met His
                565                 570                 575     
Val Val Ser Val Pro Tyr Ala Leu Met Lys Ala Asn Pro Leu Ser Trp
            580                 585                 590         
Ile Gln Lys Val Cys Phe Tyr Lys Ala Arg Ala Ala Leu Val Lys Ser
        595                 600                 605             
Arg Asp Met His Trp Ser Leu Leu Ala Gln Arg Gly Gln Arg Asp Val
    610                 615                 620                 
Ser Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn Pro
625                 630                 635                 640 
Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser Arg
                645                 650                 655     
Gly Leu Arg Pro Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu Ala
            660                 665                 670         
Leu Thr Val Ala Ile Arg Arg Pro Pro Asp Leu Gly Gly Pro Pro Pro
        675                 680                 685             
Arg Lys Ala Val Leu Ser Met Asn Gly Leu Ser Tyr Gly Val Ile Arg
    690                 695                 700                 
Val Asp Thr Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val Gly
705                 710                 715                 720 
Gln Val Met Pro Gly Ala Asn Val Cys Val Val Lys Leu Glu Gly Thr
                725                 730                 735     
Pro Tyr Leu Cys Lys Thr Asp Glu Val Gly Glu Ile Cys Val Ser Ser
            740                 745                 750         
Ser Ala Thr Gly Thr Ala Tyr Tyr Gly Leu Leu Gly Ile Thr Lys Asn
        755                 760                 765             
Val Phe Glu Ala Val Pro Val Thr Thr Gly Gly Ala Pro Ile Phe Asp
    770                 775                 780                 
Arg Pro Phe Thr Arg Thr Gly Leu Leu Gly Phe Ile Gly Pro Asp Asn
785                 790                 795                 800 
Leu Val Phe Ile Val Gly Lys Leu Asp Gly Leu Met Val Thr Gly Val
                805                 810                 815     
Arg Arg His Asn Ala Asp Asp Val Val Ala Thr Ala Leu Ala Val Glu
            820                 825                 830         
Pro Met Lys Phe Val Tyr Arg Gly Arg Ile Ala Val Phe Ser Val Thr
        835                 840                 845             
Val Leu His Asp Asp Arg Ile Val Leu Val Ala Glu Gln Arg Pro Asp
    850                 855                 860                 
Ala Ser Glu Glu Asp Ser Phe Gln Trp Met Ser Arg Val Leu Gln Ala
865                 870                 875                 880 
Ile Asp Ser Ile His Gln Val Gly Val Tyr Cys Leu Ala Leu Val Pro
                885                 890                 895     
Ala Asn Thr Leu Pro Lys Ala Pro Leu Gly Gly Ile His Ile Ser Glu
            900                 905                 910         
Thr Lys Gln Arg Phe Leu Glu Gly Thr Leu His Pro Cys Asn Val Leu
        915                 920                 925             
Met Cys Pro His Thr Cys Val Thr Asn Leu Pro Lys Pro Arg Gln Lys
    930                 935                 940                 
Gln Pro Glu Val Gly Pro Ala Ser Met Ile Val Gly Asn Leu Val Ala
945                 950                 955                 960 
Gly Lys Arg Ile Ala Gln Ala Ser Gly Arg Glu Leu Ala His Leu Glu
                965                 970                 975     
Asp Ser Asp Gln Ala Arg Lys Phe Leu Phe Leu Ala Asp Val Leu Gln
            980                 985                 990         
Trp Arg Ala His Thr Thr Pro Asp His Pro Leu Phe Leu Leu Leu Asn
        995                 1000                1005            
Ala Lys Gly Thr Val Thr Ser Thr Ala Thr Cys Val Gln Leu His Lys
    1010                1015                1020                
Arg Ala Glu Arg Val Ala Ala Ala Leu Met Glu Lys Gly Arg Leu Ser
1025                1030                1035                1040
Val Gly Asp His Val Ala Leu Val Tyr Pro Pro Gly Val Asp Leu Ile
                1045                1050                1055    
Ala Ala Phe Tyr Gly Cys Leu Tyr Cys Gly Cys Val Pro Val Thr Val
            1060                1065                1070        
Arg Pro Pro His Pro Gln Asn Leu Gly Thr Thr Leu Pro Thr Val Lys
        1075                1080                1085            
Met Ile Val Glu Val Ser Lys Ser Ala Cys Val Leu Thr Thr Gln Ala
    1090                1095                1100                
Val Thr Arg Leu Leu Arg Ser Lys Glu Ala Ala Ala Ala Val Asp Ile
1105                1110                1115                1120
Arg Thr Trp Pro Thr Ile Leu Asp Thr Asp Asp Ile Pro Lys Lys Lys
                1125                1130                1135    
Ile Ala Ser Val Phe Arg Pro Pro Ser Pro Asp Val Leu Ala Tyr Leu
            1140                1145                1150        
Asp Phe Ser Val Ser Thr Thr Gly Ile Leu Ala Gly Val Lys Met Ser
        1155                1160                1165            
His Ala Ala Thr Ser Ala Leu Cys Arg Ser Ile Lys Leu Gln Cys Glu
    1170                1175                1180                
Leu Tyr Pro Ser Arg Gln Ile Ala Ile Cys Leu Asp Pro Tyr Cys Gly
1185                1190                1195                1200
Leu Gly Phe Ala Leu Trp Cys Leu Cys Ser Val Tyr Ser Gly His Gln
                1205                1210                1215    
Ser Val Leu Val Pro Pro Leu Glu Leu Glu Ser Asn Val Ser Leu Trp
            1220                1225                1230        
Leu Ser Ala Val Ser Gln Tyr Lys Ala Arg Val Thr Phe Cys Ser Tyr
        1235                1240                1245            
Ser Val Met Glu Met Cys Thr Lys Gly Leu Gly Ala Gln Thr Gly Val
    1250                1255                1260                
Leu Arg Met Lys Gly Val Asn Leu Ser Cys Val Arg Thr Cys Met Val
1265                1270                1275                1280
Val Ala Glu Glu Arg Pro Arg Ile Ala Leu Thr Gln Ser Phe Ser Lys
                1285                1290                1295    
Leu Phe Lys Asp Leu Gly Leu Pro Ala Arg Ala Val Ser Thr Thr Phe
            1300                1305                1310        
Gly Cys Arg Val Asn Val Ala Ile Cys Leu Gln Gly Thr Ala Gly Pro
        1315                1320                1325            
Asp Pro Thr Thr Val Tyr Val Asp Met Arg Ala Leu Arg His Asp Arg
    1330                1335                1340                
Val Arg Leu Val Glu Arg Gly Ser Pro His Ser Leu Pro Leu Met Glu
1345                1350                1355                1360
Ser Gly Lys Ile Leu Pro Gly Val Lys Val Ile Ile Ala His Thr Glu
                1365                1370                1375    
Thr Lys Gly Pro Leu Gly Asp Ser His Leu Gly Glu Ile Trp Val Ser
            1380                1385                1390        
Ser Pro His Asn Ala Thr Gly Tyr Tyr Thr Val Tyr Gly Glu Glu Ala
        1395                1400                1405            
Leu His Ala Asp His Phe Ser Ala Arg Leu Ser Phe Gly Asp Thr Gln
    1410                1415                1420                
Thr Ile Trp Ala Arg Thr Gly Tyr Leu Gly Phe Leu Arg Arg Thr Glu
1425                1430                1435                1440
Leu Thr Asp Ala Ser Gly Gly Arg His Asp Ala Leu Tyr Val Val Gly
                1445                1450                1455    
Ser Leu Asp Glu Thr Leu Glu Leu Arg Gly Met Arg Tyr His Pro Ile
            1460                1465                1470        
Asp Ile Glu Thr Ser Val Ile Arg Ala His Arg Ser Ile Ala Glu Cys
        1475                1480                1485            
Ala Val Phe Thr Trp Thr Asn Leu Leu Val Val Val Val Glu Leu Asp
    1490                1495                1500                
Gly Leu Glu Gln Asp Ala Leu Asp Leu Val Ala Leu Val Thr Asn Val
1505                1510                1515                1520
Val Leu Glu Glu His Tyr Leu Val Val Gly Val Val Val Ile Val Asp
                1525                1530                1535    
Pro Gly Val Ile Pro Ile Asn Ser Arg Gly Glu Lys Gln Arg Met His
            1540                1545                1550        
Leu Arg Asp Gly Phe Leu Ala Asp Gln Leu Asp Pro Ile Tyr Val Ala
        1555                1560                1565            
Tyr Asn Met
    1570    


<210> 6271
<211> 347
<212> PRT
<213> Homo sapiens

<400> 6271
Met Asn Ile Phe Leu Ser Ser Ile Gln Arg Leu Ile His Ala His Tyr
 1               5                  10                  15      
Ser Ser Arg Leu Pro Ala Ser Ser Trp Val Leu Leu Ile Gly Ser Thr
            20                  25                  30          
Gly Gln Leu Ala Lys Gly Lys Arg Met Leu Ser Glu Tyr Leu Ser Pro
        35                  40                  45              
Asn Leu Ser Leu Arg Ala Pro Ile Asp Leu Ala Ser Pro Pro Gln Leu
    50                  55                  60                  
Lys Pro Thr Pro Leu Ser His Gln Ala Thr Leu Phe Ile Glu Tyr Ser
65                  70                  75                  80  
Val Ser Arg Ile Trp Glu Ser Phe Met Pro Ser Ser Ser Ser Thr Ala
                85                  90                  95      
Leu Leu Pro Val Gly Leu Cys Tyr Leu Cys Ile Phe Pro Ala Leu Phe
            100                 105                 110         
Pro His Leu Arg Thr Gln Ser Leu Tyr Tyr Pro Ser His Leu Val Ser
        115                 120                 125             
Trp Ser Ile Ala Lys Gly Ser Leu Leu Lys Val Thr Val Leu Leu Lys
    130                 135                 140                 
Leu Leu Gln Tyr Lys Arg Thr Gln Ala Leu Ala Phe Ala Ala Pro Pro
145                 150                 155                 160 
Gly Phe Leu Ile Ile Phe Asp Asp Cys Leu Phe Thr Ala Gly Gln Gln
                165                 170                 175     
Gly Phe Ala Asp Thr Ala Thr Thr Gly Arg Leu Ile Leu Pro Ala Met
            180                 185                 190         
Val Asn Pro Thr Val Phe Phe Asp Ile Thr Val Asp Gly Glu Pro Leu
        195                 200                 205             
Gly Ser Val Ser Phe Glu Leu Phe Ala Glu Lys Phe Pro Lys Thr Glu
    210                 215                 220                 
Glu Asn Phe His Leu Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys
225                 230                 235                 240 
Ser Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Arg Gly Asp
                245                 250                 255     
Asp Phe Thr Cys His Asn Ser Thr Gly Gly Lys Ser Val Tyr Gly Glu
            260                 265                 270         
Lys Phe Val Asp Glu Asn Phe Val Leu Lys His Thr Asp Pro Gly Ile
        275                 280                 285             
Leu Ser Arg Ala Asn Ala Gly Pro Ser Thr Asn Gly Ser Gln Phe Phe
    290                 295                 300                 
Thr Cys Thr Ala Lys Thr Glu Trp Phe Gly Lys Val Lys Glu Arg Met
305                 310                 315                 320 
Ile Ile Val Glu Ala Met Gly Arg Phe Ala Gly Asn Gly Lys Thr Ser
                325                 330                 335     
Lys Lys Ile Ala Val Ala Asp Cys Gly Leu Leu
            340                 345         


<210> 6272
<211> 276
<212> PRT
<213> Homo sapiens

<400> 6272
Phe Asn Asn Glu Ser Ser Leu Arg Glu Leu Ser Gly Thr Pro Asn Leu
 1               5                  10                  15      
Leu Asn Thr Ser Asp Ser Glu Gln Ala Gln Lys Pro Val Ser Pro Pro
            20                  25                  30          
Gly Glu Ala Ser Thr Ser Gly Gln His Ser Arg Leu Lys Leu Glu Leu
        35                  40                  45              
Arg Arg Lys Glu Thr Glu Gly Lys Met Tyr Ser Leu Arg Glu Arg Lys
    50                  55                  60                  
Gly His Ala Tyr Lys Glu Ile Ser Glu Pro Gln Asp Asp Asp Tyr Leu
65                  70                  75                  80  
Tyr Cys Glu Met Cys Gln Asn Phe Phe Ile Asp Ser Cys Ala Ala His
                85                  90                  95      
Gly Pro Pro Thr Phe Val Lys Asp Ser Ala Val Asp Lys Gly His Pro
            100                 105                 110         
Asn Arg Ser Ala Leu Ser Leu Pro Pro Gly Leu Arg Ile Gly Pro Ser
        115                 120                 125             
Gly Ile Pro Gln Ala Gly Leu Gly Val Trp Asn Glu Ala Ser Asp Leu
    130                 135                 140                 
Pro Leu Gly Leu His Phe Gly Pro Tyr Glu Gly Arg Ile Thr Glu Asp
145                 150                 155                 160 
Glu Glu Ala Ala Asn Ser Gly Tyr Ser Trp Leu Ile Thr Lys Gly Arg
                165                 170                 175     
Asn Cys Tyr Glu Tyr Val Asp Gly Lys Asp Lys Ser Ser Ala Asn Trp
            180                 185                 190         
Met Arg Tyr Val Asn Cys Ala Arg Asp Asp Glu Glu Gln Asn Leu Val
        195                 200                 205             
Ala Phe Gln Tyr His Arg Gln Ile Phe Tyr Arg Thr Cys Arg Val Ile
    210                 215                 220                 
Arg Pro Gly Cys Cys Glu Leu Leu Val Trp Tyr Gly Asp Glu Tyr Gly
225                 230                 235                 240 
Gln Glu Leu Gly Ile Lys Trp Gly Ser Lys Trp Lys Lys Glu Leu Met
                245                 250                 255     
Ala Gly Arg Gly Arg His His Tyr Tyr Ser Phe Lys Arg Thr Gly Lys
            260                 265                 270         
Lys Glu Leu Ser
        275     


<210> 6273
<211> 689
<212> PRT
<213> Homo sapiens

<400> 6273
Met Cys Gln Asn Phe Phe Ile Asp Ser Cys Ala Ala His Gly Pro Pro
 1               5                  10                  15      
Thr Phe Val Lys Asp Ser Ala Val Asp Lys Gly His Pro Asn Arg Ser
            20                  25                  30          
Ala Leu Ser Leu Pro Pro Gly Leu Arg Ile Gly Pro Ser Gly Ile Pro
        35                  40                  45              
Gln Ala Gly Leu Gly Val Trp Asn Glu Ala Ser Asp Leu Pro Leu Gly
    50                  55                  60                  
Leu His Phe Gly Pro Tyr Glu Gly Arg Ile Thr Glu Asp Glu Glu Ala
65                  70                  75                  80  
Ala Asn Asn Gly Tyr Ser Trp Leu Val Arg Arg Ala Cys His Phe Thr
                85                  90                  95      
Lys Gly Arg Asn Cys Tyr Glu Tyr Val Asp Gly Lys Asp Lys Ser Trp
            100                 105                 110         
Ala Asn Trp Met Arg Tyr Val Asn Cys Ala Arg Asp Asp Glu Glu Gln
        115                 120                 125             
Asn Leu Val Ala Phe Gln Tyr His Arg Gln Ile Phe Tyr Arg Thr Cys
    130                 135                 140                 
Arg Val Ile Arg Pro Gly Cys Glu Leu Leu Val Trp Tyr Gly Asp Glu
145                 150                 155                 160 
Tyr Gly Gln Glu Leu Gly Ile Lys Trp Gly Ser Lys Trp Lys Lys Glu
                165                 170                 175     
Glu Pro Lys Pro Glu Ile His Pro Cys Pro Ser Cys Cys Leu Ala Phe
            180                 185                 190         
Ser Ser Gln Lys Phe Leu Ser Gln His Val Glu Arg Asn His Ser Ser
        195                 200                 205             
Gln Asn Phe Pro Gly Pro Ser Ala Arg Lys Leu Leu Gln Pro Glu Asn
    210                 215                 220                 
Pro Cys Pro Gly Asp Gln Asn Gln Glu Gln Gln Tyr Pro Asp Pro His
225                 230                 235                 240 
Ser Arg Asn Asp Lys Thr Lys Gly Gln Glu Ile Lys Glu Arg Ser Lys
                245                 250                 255     
Leu Leu Asn Lys Arg Thr Trp Gln Arg Glu Ile Ser Arg Ala Phe Ser
            260                 265                 270         
Ser Pro Pro Lys Gly Gln Met Gly Ser Cys Arg Val Gly Lys Arg Ile
        275                 280                 285             
Met Glu Glu Glu Ser Arg Thr Gly Gln Lys Val Asn Pro Gly Asn Thr
    290                 295                 300                 
Gly Lys Leu Phe Val Gly Val Gly Ile Ser Arg Ile Ala Lys Val Lys
305                 310                 315                 320 
Tyr Gly Glu Cys Gly Gln Gly Phe Ser Val Lys Ser Asp Val Ile Thr
                325                 330                 335     
His Gln Arg Thr His Thr Gly Glu Lys Leu Tyr Val Cys Arg Glu Cys
            340                 345                 350         
Gly Arg Gly Phe Ser Trp Lys Ser His Leu Leu Ile His Gln Arg Ile
        355                 360                 365             
His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe
    370                 375                 380                 
Ser Trp Gln Ser Val Leu Leu Thr His Gln Arg Thr His Thr Gly Glu
385                 390                 395                 400 
Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe Ser Arg Gln Ser
                405                 410                 415     
Val Leu Leu Thr His Gln Arg Arg His Thr Gly Glu Lys Pro Tyr Val
            420                 425                 430         
Cys Arg Glu Cys Gly Arg Gly Phe Ser Arg Gln Ser Val Leu Leu Thr
        435                 440                 445             
His Gln Arg Arg His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys
    450                 455                 460                 
Gly Arg Gly Phe Ser Trp Gln Ser Val Leu Leu Thr His Gln Arg Thr
465                 470                 475                 480 
His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe
                485                 490                 495     
Ser Trp Gln Ser Val Leu Leu Thr His Gln Arg Thr His Thr Gly Glu
            500                 505                 510         
Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe Ser Asn Lys Ser
        515                 520                 525             
His Leu Leu Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val
    530                 535                 540                 
Cys Arg Glu Cys Gly Arg Gly Phe Arg Asp Lys Ser His Leu Leu Arg
545                 550                 555                 560 
His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys
                565                 570                 575     
Gly Arg Gly Phe Arg Asp Lys Ser Asn Leu Leu Ser His Gln Arg Thr
            580                 585                 590         
His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe
        595                 600                 605             
Ser Asn Lys Ser His Leu Leu Arg His Gln Arg Thr His Thr Gly Glu
    610                 615                 620                 
Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe Arg Asn Lys Ser
625                 630                 635                 640 
His Leu Leu Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val
                645                 650                 655     
Cys Arg Glu Cys Gly Arg Gly Phe Ser Asp Arg Ser Ser Leu Cys Tyr
            660                 665                 670         
His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Asp
        675                 680                 685             
Glu
    


<210> 6274
<211> 171
<212> PRT
<213> Homo sapiens

<400> 6274
Met Cys Gln Asn Phe Phe Ile Asp Ser Cys Ala Ala His Gly Pro Pro
 1               5                  10                  15      
Thr Phe Val Lys Asp Ser Ala Val Asp Lys Gly His Pro Asn Arg Ser
            20                  25                  30          
Ala Leu Ser Leu Pro Pro Gly Leu Arg Ile Gly Pro Ser Gly Ile Pro
        35                  40                  45              
Gln Ala Gly Leu Gly Val Trp Asn Glu Ala Ser Asp Leu Pro Leu Gly
    50                  55                  60                  
Leu His Phe Gly Pro Tyr Glu Gly Arg Ile Thr Glu Asp Glu Glu Ala
65                  70                  75                  80  
Ala Asn Ser Gly Tyr Ser Trp Leu Ile Thr Lys Gly Arg Asn Cys Tyr
                85                  90                  95      
Glu Tyr Val Asp Gly Lys Asp Lys Ser Ser Ala Asn Trp Met Arg Thr
            100                 105                 110         
Lys Ala Arg Asp Pro Ser Met Ser Leu Met Leu Ser Gly Leu Phe Lys
        115                 120                 125             
Ser Lys Ile Ser Gln Ser Thr Cys Gly Thr Gln Ser Leu Leu Ser Glu
    130                 135                 140                 
Leu Pro Arg Thr Ile Cys Lys Lys Thr Ser Pro Thr Arg Glu Ser Leu
145                 150                 155                 160 
Pro Arg Gly Ser Glu Ser Gly Ala Ala Ile Phe
                165                 170     


<210> 6275
<211> 407
<212> PRT
<213> Homo sapiens

<400> 6275
Met Cys Gln Asn Phe Phe Ile Asp Ser Cys Ala Ala His Gly Pro Pro
 1               5                  10                  15      
Thr Phe Val Lys Asp Ser Ala Val Asp Lys Gly His Pro Asn Arg Ser
            20                  25                  30          
Ala Leu Ser Leu Pro Pro Gly Leu Arg Ile Gly Pro Ser Gly Ile Pro
        35                  40                  45              
Gln Ala Gly Leu Gly Val Trp Asn Glu Ala Ser Asp Leu Pro Leu Gly
    50                  55                  60                  
Leu His Phe Gly Pro Tyr Glu Gly Arg Ile Thr Glu Asp Glu Glu Ala
65                  70                  75                  80  
Ala Asn Ser Gly Tyr Ser Trp Leu Ile Thr Lys Gly Arg Asn Cys Tyr
                85                  90                  95      
Glu Tyr Val Asp Gly Lys Asp Lys Ser Ser Ala Asn Trp Met Arg Tyr
            100                 105                 110         
Val Asn Cys Ala Arg Asp Asp Glu Glu Gln Asn Leu Val Ala Phe Gln
        115                 120                 125             
Tyr His Arg Gln Ile Phe Tyr Arg Thr Cys Arg Val Ile Arg Pro Gly
    130                 135                 140                 
Cys Glu Leu Leu Val Trp Tyr Gly Asp Glu Tyr Gly Gln Glu Leu Gly
145                 150                 155                 160 
Ile Lys Trp Gly Ser Lys Trp Lys Lys Glu Leu Met Ala Gly Arg Glu
                165                 170                 175     
Pro Lys Pro Glu Ile His Pro Cys Pro Ser Cys Cys Leu Ala Phe Ser
            180                 185                 190         
Ser Gln Lys Phe Leu Ser Gln His Val Glu Arg Asn His Ser Ser Gln
        195                 200                 205             
Asn Phe Pro Gly Pro Ser Ala Arg Lys Leu Leu Gln Pro Glu Asn Pro
    210                 215                 220                 
Cys Pro Gly Asp Gln Asn Gln Glu Arg Gln Tyr Ser Asp Pro Arg Cys
225                 230                 235                 240 
Cys Asn Asp Lys Thr Lys Gly Gln Glu Ile Lys Glu Arg Ser Lys Leu
                245                 250                 255     
Leu Asn Lys Arg Thr Trp Gln Arg Glu Ile Ser Arg Ala Phe Ser Ser
            260                 265                 270         
Pro Pro Lys Gly Gln Met Gly Ser Ser Arg Val Gly Glu Arg Met Met
        275                 280                 285             
Glu Glu Glu Ser Arg Thr Gly Gln Lys Val Asn Pro Gly Asn Thr Gly
    290                 295                 300                 
Lys Leu Phe Val Gly Val Gly Ile Ser Arg Ile Ala Lys Val Lys Tyr
305                 310                 315                 320 
Gly Glu Cys Gly Gln Gly Phe Ser Asp Lys Ser Asp Val Ile Thr His
                325                 330                 335     
Gln Arg Thr His Thr Gly Gly Lys Pro Tyr Val Cys Arg Glu Cys Gly
            340                 345                 350         
Glu Gly Phe Ser Arg Lys Ser Asp Leu Leu Ser His Gln Arg Thr His
        355                 360                 365             
Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys Glu Arg Gly Phe Ser
    370                 375                 380                 
Arg Lys Ser Val Leu Leu Ile His Gln Arg Thr His Arg Gly Glu Ala
385                 390                 395                 400 
Pro Val Cys Arg Lys Asp Glu
                405         


<210> 6276
<211> 456
<212> PRT
<213> Homo sapiens

<400> 6276
Met Gly Lys Lys Lys Thr His Ile Asn Ile Ile Ile Thr Gly His Val
 1               5                  10                  15      
Asp Ser Phe Lys Ser Ile Thr Thr Cys His Pro Val Tyr Lys Cys Gly
            20                  25                  30          
Gly Ile Asp Gln Arg Thr Ile Lys Lys Cys Glu Asp Lys Thr Ala Glu
        35                  40                  45              
Met Gly Lys Gly Ser Phe Arg Tyr Ala Trp Val Leu Asp Lys Leu Lys
    50                  55                  60                  
Ala Glu Phe Glu His Gly Ile Thr Thr Asp Ile Ser Thr Trp Glu Ser
65                  70                  75                  80  
Glu Thr Thr Lys Tyr Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His
                85                  90                  95      
Arg Glu Phe Thr Lys Asn Met Ile Thr Glu Thr Tyr Gln Ile Asp Cys
            100                 105                 110         
Ala Ile Leu Thr Val Ala Ala Gly Ala Asp Glu Ser Glu Leu Gly Ile
        115                 120                 125             
Ser Lys Asn Glu Gln Thr His Glu His Ile Pro Leu Ala Ser Thr Leu
    130                 135                 140                 
Ile Val Lys Gln Pro Thr Val His Val Asn Lys Thr Asp Ser Thr Glu
145                 150                 155                 160 
Ser Pro Tyr Ser Gln Lys Arg Tyr Glu Lys Ile Ile Lys Glu Ile Ser
                165                 170                 175     
Thr His Ile Lys Lys Thr Gly Tyr Gly Pro Ala Thr Val Ala Phe Val
            180                 185                 190         
Pro Ile Ser Phe Leu Asn Gly Asp Asn Met Leu Glu Ser Ser Ala Asn
        195                 200                 205             
Ile Pro Trp Leu Lys Arg Trp Lys Asp Thr Cys Lys Asp Gly Asp Thr
    210                 215                 220                 
Ser Glu Thr Met Leu Leu Lys Ala Leu Asn Cys Ile Leu Pro Ser Ile
225                 230                 235                 240 
His Ser Val Asp Lys Leu Leu Cys Leu Pro Leu Pro Asp Val Tyr Lys
                245                 250                 255     
Gly Asp Ile Gly Ile Val Pro Leu Gly Leu Val Glu Thr Ala Ile Leu
            260                 265                 270         
Lys Pro Ser Met Trp Ser Thr Phe Ala Pro Val Asn Thr Thr Thr Glu
        275                 280                 285             
Val Glu Ser Val Glu Met His Gln Lys Ala Leu Ser Glu Ala Leu Pro
    290                 295                 300                 
Lys Asp Asn Val Gly Phe Asp Val Lys Asn Val Ser Val Lys Asp Thr
305                 310                 315                 320 
Arg His Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Ser Pro Met Glu
                325                 330                 335     
Ala Ala Asp Cys Thr Ala His Met Ile Ile Leu Ser Gln Pro Gly Gln
            340                 345                 350         
Ile Gly Ser Gly Tyr Pro Pro Ile Leu Asp Cys His Thr Ala Tyr Val
        355                 360                 365             
Ala Cys Lys Phe Ala Ile Glu Lys Ile Asp Cys His Ser Gly Lys Lys
    370                 375                 380                 
Leu Glu Gly Asp Pro Lys Phe Leu Lys Ser Ser Asp Ala Ala Ile Val
385                 390                 395                 400 
Gln Met Val Ala Gly Val Glu Ser Phe Ser Asp His Leu Pro Leu Gly
                405                 410                 415     
His Phe Thr Val His Asn Met Arg Gln Thr Val Ala Val Gly Val Phe
            420                 425                 430         
Lys Ala Val Asp Lys Arg Ala Ala Arg Val Gly Lys Val Ser Lys Ser
        435                 440                 445             
Ala Trp Lys Val Gln Glu Ala Lys
    450                 455     


<210> 6277
<211> 196
<212> PRT
<213> Homo sapiens

<400> 6277
Met Leu Phe Arg Val Leu Thr Ser Lys Val Thr Lys Gly Thr Met Ile
 1               5                  10                  15      
Met Pro Lys Arg Val Ala Ala Thr Cys Val Pro Lys Asp Arg Ala Ile
            20                  25                  30          
Lys Asn Phe Phe Ile Gln Asn Thr Val Glu Ala Ala Ala Ser Val Phe
        35                  40                  45              
Asn Ala Tyr Val Leu Pro Glu Leu Tyr Val Lys Leu His Tyr Cys Val
    50                  55                  60                  
Ser Cys Ala Ile His Ser Arg Lys Pro Ala Arg Thr Glu His Leu His
65                  70                  75                  80  
Phe Tyr Leu Asp Leu Gln Met Leu Ala Pro Lys Leu Met Asn Lys Thr
                85                  90                  95      
Pro Gln Pro Gly Cys Arg Lys Gly Cys Arg Cys Asp Pro Gln Gly Val
            100                 105                 110         
Asn Ala Thr Ala Thr Ala Asp Arg Leu Trp Leu Gly Trp Arg Leu Glu
        115                 120                 125             
Gln Glu Lys Glu Glu Gln Glu Lys Glu Gly Ala Gly Gly Trp Lys Arg
    130                 135                 140                 
Leu Gln Ala Ala Ala Ala Ala Thr Trp Ser Asn Gln Ala Val Arg Gln
145                 150                 155                 160 
Leu Pro Ala Pro Gly Pro Phe His Leu Phe Pro Phe Gly Arg Arg Ser
                165                 170                 175     
Arg Val Gln Ile Arg His Ser Ala Pro Glu Thr Asp Thr Leu Asn Ser
            180                 185                 190         
Thr Ser Ser Ser
        195     


<210> 6278
<211> 755
<212> PRT
<213> Homo sapiens

<400> 6278
Met Lys Lys Gln Arg Lys Ile Leu Trp Arg Lys Gly Ile His Leu Ala
 1               5                  10                  15      
Phe Ser Glu Lys Trp Asn Thr Gly Phe Gly Gly Phe Lys Lys Phe Tyr
            20                  25                  30          
Phe His Gln His Leu Cys Ile Leu Lys Ala Lys Leu Gly Arg Pro Val
        35                  40                  45              
Thr Trp Asn Arg Gln Leu Arg His Phe Gln Gly Arg Lys Lys Ala Leu
    50                  55                  60                  
Gln Ile Gln Lys Thr Trp Ile Lys Asp Glu His Leu Cys Ala Lys Thr
65                  70                  75                  80  
Lys Phe Asn Val Ala Thr Gln Asn Val Ser Thr Leu Ser Ser Lys Val
                85                  90                  95      
Lys Arg Lys Asp Ala Lys His Phe Ile Ser Ser Ser Lys Thr Leu Leu
            100                 105                 110         
Arg Leu Gln Ala Glu Lys Leu Leu Ser Ser Ala Lys Asn Ser Asp His
        115                 120                 125             
Glu Tyr Cys Arg Glu Lys Asn Leu Leu Lys Ala Val Thr Asp Phe Pro
    130                 135                 140                 
Ser Asn Ser Ala Leu Gly Gln Ala Asn Gly His Arg Pro Arg Thr Asp
145                 150                 155                 160 
Pro Gln Pro Ser Asp Phe Pro Met Lys Phe Asn Gly Glu Ser Gln Ser
                165                 170                 175     
Pro Gly Glu Ser Gly Thr Ile Val Val Thr Leu Asn Asn His Lys Arg
            180                 185                 190         
Lys Gly Phe Cys Tyr Gly Cys Cys Gln Gly Pro Glu His His Arg Asn
        195                 200                 205             
Gly Gly Pro Leu Ile Pro Lys Lys Phe Gln Leu Asn Gln His Arg Arg
    210                 215                 220                 
Ile Lys Leu Ser Pro Leu Met Met Tyr Glu Lys Leu Ser Met Ile Arg
225                 230                 235                 240 
Phe Arg Tyr Arg Ile Leu Arg Ser Gln His Phe Arg Thr Lys Ser Lys
                245                 250                 255     
Val Cys Lys Leu Arg Lys Ala Gln Arg Ser Trp Val Gln Lys Val Thr
            260                 265                 270         
Gly Asp His Gln Glu Thr Arg Arg Glu Asn Gly Glu Gly Gly Ser Cys
        275                 280                 285             
Ser Pro Phe Pro Ser Pro Glu Pro Lys Asp Pro Ser Cys Arg His Gln
    290                 295                 300                 
Pro Tyr Phe Pro Asp Met Asp Ser Ser Ala Val Val Lys Gly Thr Asn
305                 310                 315                 320 
Ser His Val Pro Asp Cys His Thr Lys Gly Ser Ser Phe Leu Gly Lys
                325                 330                 335     
Glu Leu Ser Leu Asp Glu Ala Phe Pro Asp Gln Gln Asn Gly Ser Ala
            340                 345                 350         
Thr Asn Ala Trp Asp Gln Ser Ser Cys Ser Ser Pro Lys Trp Glu Cys
        355                 360                 365             
Thr Glu Leu Ile His Asp Ile Pro Leu Pro Glu His Arg Ser Asn Thr
    370                 375                 380                 
Met Phe Ile Ser Glu Thr Glu Arg Glu Ile Met Thr Leu Gly Gln Glu
385                 390                 395                 400 
Asn Gln Thr Ser Ser Val Ser Asp Asp Arg Val Lys Leu Ser Val Ser
                405                 410                 415     
Gly Ala Asp Thr Ser Val Ser Ser Val Asp Gly Pro Val Ser Gln Lys
            420                 425                 430         
Ala Val Gln Asn Glu Asn Ser Tyr Gln Met Glu Glu Asp Gly Ser Leu
        435                 440                 445             
Lys Gln Ser Ile Leu Ser Ser Glu Leu Leu Asp His Pro Tyr Cys Lys
    450                 455                 460                 
Ser Pro Leu Glu Ala Pro Leu Val Cys Ser Gly Leu Lys Leu Glu Asn
465                 470                 475                 480 
Gln Val Gly Gly Gly Lys Asn Ser Gln Lys Ala Ser Pro Val Asp Asp
                485                 490                 495     
Glu Gln Leu Ser Val Cys Leu Ser Gly Phe Leu Asp Glu Val Met Lys
            500                 505                 510         
Lys Tyr Gly Ser Leu Val Pro Leu Ser Glu Lys Glu Val Leu Gly Arg
        515                 520                 525             
Leu Lys Asp Val Phe Asn Glu Asp Phe Ser Asn Arg Lys Pro Phe Ile
    530                 535                 540                 
Asn Arg Glu Ile Thr Asn Tyr Arg Ala Arg His Gln Lys Cys Asn Phe
545                 550                 555                 560 
Arg Ile Phe Tyr Asn Lys His Met Leu Asp Met Asp Asp Leu Ala Thr
                565                 570                 575     
Leu Asp Gly Gln Asn Trp Leu Asn Asp Gln Val Ile Asn Met Tyr Gly
            580                 585                 590         
Glu Leu Ile Met Asp Ala Val Pro Asp Lys Val His Phe Phe Asn Ser
        595                 600                 605             
Phe Phe His Arg Gln Leu Val Thr Lys Gly Tyr Asn Gly Val Lys Arg
    610                 615                 620                 
Trp Thr Lys Lys Val Asp Leu Phe Lys Lys Ser Leu Leu Leu Ile Pro
625                 630                 635                 640 
Ile His Leu Glu Val His Trp Ser Leu Ile Thr Val Thr Leu Ser Asn
                645                 650                 655     
Arg Ile Ile Ser Phe Tyr Asp Ser Gln Gly Ile His Phe Lys Phe Cys
            660                 665                 670         
Val Glu Asn Ile Arg Lys Tyr Leu Leu Thr Glu Ala Arg Glu Lys Asn
        675                 680                 685             
Arg Pro Glu Phe Leu Gln Gly Trp Gln Thr Ala Val Thr Lys Cys Ile
    690                 695                 700                 
Pro Gln Gln Lys Asn Asp Ser Asp Cys Gly Val Phe Val Leu Gln Tyr
705                 710                 715                 720 
Cys Lys Cys Leu Ala Leu Glu Gln Pro Phe Gln Phe Ser Gln Glu Asp
                725                 730                 735     
Met Pro Arg Val Arg Lys Arg Ile Tyr Lys Glu Leu Cys Glu Cys Arg
            740                 745                 750         
Leu Met Asp
        755 


<210> 6279
<211> 386
<212> PRT
<213> Homo sapiens

<400> 6279
Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr
 1               5                  10                  15      
Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr
            20                  25                  30          
Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu
        35                  40                  45              
Leu Trp Asp Thr Gly Val Phe Arg Gly Pro Val Leu Pro Lys Arg Gln
    50                  55                  60                  
Ser Asn His Arg Gln Glu Val Tyr Phe Arg Phe Glu Asn His Ala Glu
65                  70                  75                  80  
Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Arg Leu Pro Ala Asn Arg
                85                  90                  95      
Arg Phe Gln Ile Thr Trp Phe Val Ser Trp Asn Pro Cys Leu Pro Cys
            100                 105                 110         
Val Val Lys Val Thr Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu
        115                 120                 125             
Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg
    130                 135                 140                 
Trp Val Leu Leu Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met
145                 150                 155                 160 
Asp Tyr Glu Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys Asn Glu
                165                 170                 175     
Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Ser
            180                 185                 190         
Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met
        195                 200                 205             
Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Leu Lys Ala Cys
    210                 215                 220                 
Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val Thr Lys His
225                 230                 235                 240 
His Ser Ala Val Phe Arg Lys Arg Gly Val Phe Arg Asn Gln Val Asp
                245                 250                 255     
Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys
            260                 265                 270         
Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr
        275                 280                 285             
Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu
    290                 295                 300                 
Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Cys
305                 310                 315                 320 
Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Cys Ser Leu Ser Gln
                325                 330                 335     
Glu Gly Ala Ser Val Lys Ile Met Gly Tyr Lys Asp Phe Val Ser Cys
            340                 345                 350         
Trp Lys Asn Phe Val Tyr Ser Asp Asp Glu Pro Phe Lys Pro Trp Lys
        355                 360                 365             
Gly Leu Gln Thr Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ile
    370                 375                 380                 
Leu Gln
385     


<210> 6280
<211> 1675
<212> PRT
<213> Homo sapiens

<400> 6280
Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln
 1               5                  10                  15      
Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met
            20                  25                  30          
Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala
        35                  40                  45              
Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg
    50                  55                  60                  
Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile
65                  70                  75                  80  
Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys
                85                  90                  95      
Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys
            100                 105                 110         
Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr
        115                 120                 125             
His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg
    130                 135                 140                 
His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala
145                 150                 155                 160 
Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg
                165                 170                 175     
Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln
            180                 185                 190         
Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly
        195                 200                 205             
Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala
    210                 215                 220                 
Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn
225                 230                 235                 240 
Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala
                245                 250                 255     
Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val
            260                 265                 270         
Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu
        275                 280                 285             
Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe
    290                 295                 300                 
Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg
305                 310                 315                 320 
Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro
                325                 330                 335     
Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala
            340                 345                 350         
Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe
        355                 360                 365             
Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala
    370                 375                 380                 
Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg
385                 390                 395                 400 
Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln
                405                 410                 415     
Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser
            420                 425                 430         
Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu
        435                 440                 445             
Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly
    450                 455                 460                 
Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu
465                 470                 475                 480 
Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly
                485                 490                 495     
Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro
            500                 505                 510         
Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln
        515                 520                 525             
Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala
    530                 535                 540                 
Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln
545                 550                 555                 560 
Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser
                565                 570                 575     
Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala
            580                 585                 590         
Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr
        595                 600                 605             
Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln
    610                 615                 620                 
Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val
625                 630                 635                 640 
Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly
                645                 650                 655     
Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser
            660                 665                 670         
Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys
        675                 680                 685             
Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser
    690                 695                 700                 
Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn
705                 710                 715                 720 
Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys
                725                 730                 735     
Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn
            740                 745                 750         
Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu
        755                 760                 765             
Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val
    770                 775                 780                 
His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile
785                 790                 795                 800 
Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile
                805                 810                 815     
Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu
            820                 825                 830         
Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu
        835                 840                 845             
Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala
    850                 855                 860                 
Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala
865                 870                 875                 880 
Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu
                885                 890                 895     
Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg
            900                 905                 910         
Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu
        915                 920                 925             
Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser
    930                 935                 940                 
Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu
945                 950                 955                 960 
Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln
                965                 970                 975     
Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val
            980                 985                 990         
Lys Ala Phe Met Thr Ala Asp Leu Pro Asn Glu Leu Ile Glu Leu Leu
        995                 1000                1005            
Glu Lys Ile Val Leu Asp Asn Ser Val Phe Ser Glu His Arg Asn Leu
    1010                1015                1020                
Gln Asn Leu Leu Ile Leu Thr Ala Ile Lys Ala Asp Arg Thr Arg Val
1025                1030                1035                1040
Met Glu Tyr Ile Asn Arg Leu Asp Asn Tyr Asp Ala Pro Asp Ile Ala
                1045                1050                1055    
Asn Ile Ala Ile Ser Asn Glu Leu Phe Glu Glu Ala Phe Ala Ile Phe
            1060                1065                1070        
Arg Lys Phe Asp Val Asn Thr Ser Ala Val Gln Val Leu Ile Glu His
        1075                1080                1085            
Ile Gly Asn Leu Asp Arg Ala Tyr Glu Phe Ala Glu Arg Cys Asn Glu
    1090                1095                1100                
Pro Ala Val Trp Ser Gln Leu Ala Lys Ala Gln Leu Gln Lys Gly Met
1105                1110                1115                1120
Val Lys Glu Ala Ile Asp Ser Tyr Ile Lys Ala Asp Asp Pro Ser Ser
                1125                1130                1135    
Tyr Met Glu Val Val Gln Ala Ala Asn Thr Ser Gly Asn Trp Glu Glu
            1140                1145                1150        
Leu Val Lys Tyr Leu Gln Met Ala Arg Lys Lys Ala Arg Glu Ser Tyr
        1155                1160                1165            
Val Glu Thr Glu Leu Ile Phe Ala Leu Ala Lys Thr Asn Arg Leu Ala
    1170                1175                1180                
Glu Leu Glu Glu Phe Ile Asn Gly Pro Asn Asn Ala His Ile Gln Gln
1185                1190                1195                1200
Val Gly Asp Arg Cys Tyr Asp Glu Lys Met Tyr Asp Ala Ala Lys Leu
                1205                1210                1215    
Leu Tyr Asn Asn Val Ser Asn Phe Gly Arg Leu Ala Ser Thr Leu Val
            1220                1225                1230        
His Leu Gly Glu Tyr Gln Ala Ala Val Asp Gly Ala Arg Lys Ala Asn
        1235                1240                1245            
Ser Thr Arg Thr Trp Lys Glu Val Cys Phe Ala Cys Val Asp Gly Lys
    1250                1255                1260                
Glu Phe Arg Leu Ala Gln Met Cys Gly Leu His Ile Val Val His Ala
1265                1270                1275                1280
Asp Glu Leu Glu Glu Leu Ile Asn Tyr Tyr Gln Asp Arg Gly Tyr Phe
                1285                1290                1295    
Glu Glu Leu Ile Thr Met Leu Glu Ala Ala Leu Gly Leu Glu Arg Ala
            1300                1305                1310        
His Met Gly Met Phe Thr Glu Leu Ala Ile Leu Tyr Ser Lys Phe Lys
        1315                1320                1325            
Pro Gln Lys Met Arg Glu His Leu Glu Leu Phe Trp Ser Arg Val Asn
    1330                1335                1340                
Ile Pro Lys Val Leu Arg Ala Ala Glu Gln Ala His Leu Trp Ala Glu
1345                1350                1355                1360
Leu Val Phe Leu Tyr Asp Lys Tyr Glu Glu Tyr Asp Asn Ala Ile Ile
                1365                1370                1375    
Thr Met Met Asn His Pro Thr Asp Ala Trp Lys Glu Gly Gln Phe Lys
            1380                1385                1390        
Asp Ile Ile Thr Lys Val Ala Asn Val Glu Leu Tyr Tyr Arg Ala Ile
        1395                1400                1405            
Gln Phe Tyr Leu Glu Phe Lys Pro Leu Leu Leu Asn Asp Leu Leu Met
    1410                1415                1420                
Val Leu Ser Pro Arg Leu Asp His Thr Arg Ala Val Asn Tyr Phe Ser
1425                1430                1435                1440
Lys Val Lys Gln Leu Pro Leu Val Lys Pro Tyr Leu Arg Ser Val Gln
                1445                1450                1455    
Asn His Asn Asn Lys Ser Val Asn Glu Ser Leu Asn Asn Leu Phe Ile
            1460                1465                1470        
Thr Glu Glu Asp Tyr Gln Ala Leu Arg Thr Ser Ile Asp Ala Tyr Asp
        1475                1480                1485            
Asn Phe Asp Asn Ile Ser Leu Ala Gln Arg Leu Glu Lys His Glu Leu
    1490                1495                1500                
Ile Glu Phe Arg Arg Ile Ala Ala Tyr Leu Phe Lys Gly Asn Asn Arg
1505                1510                1515                1520
Trp Lys Gln Ser Val Glu Leu Cys Lys Lys Asp Ser Leu Tyr Lys Asp
                1525                1530                1535    
Ala Met Gln Tyr Ala Ser Glu Ser Lys Asp Thr Glu Leu Ala Glu Glu
            1540                1545                1550        
Leu Leu Gln Trp Phe Leu Gln Glu Glu Lys Arg Glu Cys Phe Gly Ala
        1555                1560                1565            
Cys Leu Phe Thr Cys Tyr Asp Leu Leu Arg Pro Asp Val Val Leu Glu
    1570                1575                1580                
Thr Ala Trp Arg His Asn Ile Met Asp Phe Ala Met Pro Tyr Phe Ile
1585                1590                1595                1600
Gln Val Met Lys Glu Tyr Leu Thr Lys Val Asp Lys Leu Asp Ala Ser
                1605                1610                1615    
Glu Ser Leu Arg Lys Glu Glu Glu Gln Ala Thr Glu Thr Gln Pro Ile
            1620                1625                1630        
Val Tyr Gly Gln Pro Gln Leu Met Leu Thr Ala Gly Pro Ser Val Ala
        1635                1640                1645            
Val Pro Pro Gln Ala Pro Phe Gly Tyr Gly Tyr Thr Ala Pro Pro Tyr
    1650                1655                1660                
Gly Gln Pro Gln Pro Gly Phe Gly Tyr Ser Met
1665                1670                1675


<210> 6281
<211> 1116
<212> PRT
<213> Homo sapiens

<400> 6281
Met Ala Ala Asp Leu Asn Leu Glu Trp Ile Ser Leu Pro Arg Ser Trp
 1               5                  10                  15      
Thr Tyr Gly Ile Thr Arg Gly Gly Arg Val Phe Phe Ile Asn Glu Glu
            20                  25                  30          
Ala Lys Ser Thr Thr Trp Leu His Pro Val Thr Gly Glu Ala Val Val
        35                  40                  45              
Thr Gly His Arg Arg Gln Ser Thr Asp Leu Pro Thr Gly Trp Glu Glu
    50                  55                  60                  
Ala Tyr Thr Phe Glu Gly Ala Arg Tyr Tyr Ile Asn His Asn Glu Arg
65                  70                  75                  80  
Lys Val Thr Cys Lys His Pro Val Thr Gly Gln Pro Ser Gln Asp Asn
                85                  90                  95      
Cys Ile Phe Val Val Asn Glu Gln Thr Val Ala Thr Met Thr Ser Glu
            100                 105                 110         
Glu Lys Lys Glu Arg Pro Ile Ser Met Ile Asn Glu Ala Ser Asn Tyr
        115                 120                 125             
Asn Val Thr Ser Asp Tyr Ala Val His Pro Met Ser Pro Val Gly Arg
    130                 135                 140                 
Thr Ser Arg Ala Ser Lys Lys Val His Asn Phe Gly Lys Arg Ser Asn
145                 150                 155                 160 
Ser Ile Lys Arg Asn Pro Asn Ala Pro Val Val Arg Arg Gly Trp Leu
                165                 170                 175     
Tyr Lys Gln Asp Ser Thr Gly Met Lys Leu Trp Lys Lys Arg Trp Phe
            180                 185                 190         
Val Leu Ser Asp Leu Cys Leu Phe Tyr Tyr Arg Asp Glu Lys Glu Glu
        195                 200                 205             
Gly Ile Leu Gly Ser Ile Leu Leu Pro Ser Phe Gln Ile Ala Leu Leu
    210                 215                 220                 
Thr Ser Glu Asp His Ile Asn Arg Lys Tyr Ala Phe Lys Ala Ala His
225                 230                 235                 240 
Pro Asn Met Arg Thr Tyr Tyr Phe Cys Thr Asp Thr Gly Lys Glu Met
                245                 250                 255     
Glu Leu Trp Met Lys Ala Met Leu Asp Ala Ala Leu Val Gln Thr Glu
            260                 265                 270         
Pro Val Lys Arg Val Asp Lys Ile Thr Ser Glu Asn Ala Pro Thr Lys
        275                 280                 285             
Glu Thr Asn Asn Ile Pro Asn His Arg Val Leu Ile Lys Pro Glu Ile
    290                 295                 300                 
Gln Asn Asn Gln Lys Asn Lys Glu Met Ser Lys Ile Glu Glu Lys Lys
305                 310                 315                 320 
Ala Leu Glu Ala Glu Lys Tyr Gly Phe Gln Lys Asp Gly Gln Asp Arg
                325                 330                 335     
Pro Leu Thr Lys Ile Asn Ser Val Lys Leu Asn Ser Leu Pro Ser Glu
            340                 345                 350         
Tyr Glu Ser Gly Ser Ala Cys Pro Ala Gln Thr Val His Tyr Arg Pro
        355                 360                 365             
Ile Asn Leu Ser Ser Ser Glu Asn Lys Ile Val Asn Val Ser Leu Ala
    370                 375                 380                 
Asp Leu Arg Gly Gly Asn Arg Pro Asn Thr Gly Pro Leu Tyr Thr Glu
385                 390                 395                 400 
Ala Asp Arg Val Ile Gln Arg Thr Asn Ser Met Gln Gln Leu Glu Gln
                405                 410                 415     
Trp Ile Lys Ile Gln Lys Gly Arg Gly His Glu Glu Glu Thr Arg Gly
            420                 425                 430         
Val Ile Ser Tyr Gln Thr Leu Pro Arg Asn Met Pro Ser His Arg Ala
        435                 440                 445             
Gln Ile Met Ala Arg Tyr Pro Glu Gly Tyr Arg Thr Leu Pro Arg Asn
    450                 455                 460                 
Ser Lys Thr Arg Pro Glu Ser Ile Cys Ser Val Thr Pro Ser Thr His
465                 470                 475                 480 
Asp Lys Thr Leu Gly Pro Gly Ala Glu Glu Lys Arg Arg Ser Met Arg
                485                 490                 495     
Asp Asp Thr Met Trp Gln Leu Tyr Glu Trp Gln Gln Arg Gln Phe Tyr
            500                 505                 510         
Asn Lys Gln Ser Thr Leu Pro Arg His Ser Thr Leu Ser Ser Pro Lys
        515                 520                 525             
Thr Met Val Asn Ile Ser Asp Gln Thr Met His Ser Ile Pro Thr Ser
    530                 535                 540                 
Pro Ser His Gly Ser Ile Ala Ala Tyr Gln Gly Tyr Ser Pro Gln Arg
545                 550                 555                 560 
Thr Tyr Arg Ser Glu Val Ser Ser Pro Ile Gln Arg Gly Asp Val Thr
                565                 570                 575     
Ile Asp Arg Arg His Arg Ala His His Pro Lys His Val Tyr Val Pro
            580                 585                 590         
Asp Arg Arg Ser Val Pro Ala Gly Leu Thr Leu Gln Ser Val Ser Pro
        595                 600                 605             
Gln Ser Leu Gln Gly Lys Thr Leu Ser Gln Asp Glu Gly Arg Gly Thr
    610                 615                 620                 
Leu Tyr Lys Tyr Arg Pro Glu Glu Val Asp Ile Asp Ala Lys Leu Ser
625                 630                 635                 640 
Arg Leu Cys Glu Gln Asp Lys Val Val His Ala Leu Glu Glu Lys Leu
                645                 650                 655     
Gln Gln Leu His Lys Glu Lys Tyr Thr Leu Glu Gln Ala Leu Leu Ser
            660                 665                 670         
Ala Ser Gln Glu Ile Glu Met His Ala Asp Asn Pro Ala Ala Ile Gln
        675                 680                 685             
Thr Val Val Leu Gln Arg Asp Asp Leu Gln Asn Gly Leu Leu Ser Thr
    690                 695                 700                 
Cys Arg Glu Leu Ser Arg Ala Thr Ala Glu Leu Glu Arg Ala Trp Arg
705                 710                 715                 720 
Glu Tyr Asp Lys Leu Glu Tyr Asp Val Thr Val Thr Arg Asn Gln Met
                725                 730                 735     
Gln Glu Gln Leu Asp His Leu Gly Glu Val Gln Thr Glu Ser Ala Gly
            740                 745                 750         
Ile Gln Arg Ala Gln Ile Gln Lys Glu Leu Trp Arg Ile Gln Asp Val
        755                 760                 765             
Met Glu Gly Leu Ser Lys His Lys Gln Gln Arg Gly Thr Thr Glu Ile
    770                 775                 780                 
Gly Met Ile Gly Ser Lys Pro Phe Ser Thr Val Lys Tyr Lys Asn Glu
785                 790                 795                 800 
Gly Pro Asp Tyr Arg Leu Tyr Lys Ser Glu Pro Glu Leu Thr Thr Val
                805                 810                 815     
Ala Glu Val Asp Glu Ser Asn Gly Glu Glu Lys Ser Glu Pro Val Ser
            820                 825                 830         
Glu Ile Glu Thr Ser Val Val Lys Gly Ser His Phe Pro Val Gly Val
        835                 840                 845             
Val Pro Pro Arg Ala Lys Ser Pro Thr Pro Glu Ser Ser Thr Ile Ala
    850                 855                 860                 
Ser Tyr Val Thr Leu Arg Lys Thr Lys Lys Met Met Asp Leu Arg Thr
865                 870                 875                 880 
Glu Arg Pro Arg Ser Ala Val Glu Gln Leu Cys Leu Ala Glu Ser Thr
                885                 890                 895     
Arg Pro Arg Met Thr Val Glu Glu Gln Met Glu Arg Ile Arg Arg His
            900                 905                 910         
Gln Gln Ala Cys Leu Arg Glu Lys Lys Lys Gly Leu Asn Val Ile Gly
        915                 920                 925             
Ala Ser Asp Gln Ser Pro Leu Gln Ser Pro Ser Asn Leu Arg Asp Asn
    930                 935                 940                 
Pro Phe Arg Thr Thr Gln Thr Arg Arg Arg Asp Asp Lys Glu Leu Asp
945                 950                 955                 960 
Thr Ala Ile Arg Glu Asn Asp Val Lys Pro Asp His Glu Thr Pro Ala
                965                 970                 975     
Thr Glu Ile Val Gln Leu Lys Glu Thr Glu Pro Gln Asn Val Asp Phe
            980                 985                 990         
Ser Lys Glu Leu Lys Lys Thr Glu Asn Ile Ser Tyr Glu Met Leu Phe
        995                 1000                1005            
Glu Pro Glu Pro Asn Gly Val Asn Ser Val Glu Met Met Asp Lys Glu
    1010                1015                1020                
Arg Asn Lys Asp Lys Met Pro Glu Asp Val Thr Phe Ser Pro Gln Asp
1025                1030                1035                1040
Glu Thr Gln Thr Ala Asn His Lys Pro Glu Glu His Pro Glu Glu Asn
                1045                1050                1055    
Thr Lys Asn Ser Val Asp Glu Gln Glu Glu Thr Val Ile Ser Tyr Glu
            1060                1065                1070        
Ser Thr Pro Glu Val Ser Arg Gly Asn Gln Thr Met Ala Val Lys Ser
        1075                1080                1085            
Leu Ser Pro Ser Pro Glu Ser Ser Ala Ser Pro Val Pro Ser Thr Gln
    1090                1095                1100                
Pro Gln Leu Thr Glu Gly Ser His Phe Met Cys Val
1105                1110                1115    


<210> 6282
<211> 1175
<212> PRT
<213> Homo sapiens

<400> 6282
Asp Met Ala Ala Asp Leu Asn Leu Glu Trp Ile Ser Leu Pro Arg Ser
 1               5                  10                  15      
Trp Thr Tyr Gly Ile Thr Arg Gly Gly Arg Val Phe Phe Ile Asn Glu
            20                  25                  30          
Glu Ala Lys Ser Thr Thr Trp Leu His Pro Val Thr Gly Glu Ala Val
        35                  40                  45              
Val Thr Gly His Arg Arg Gln Ser Thr Asp Leu Pro Thr Gly Trp Glu
    50                  55                  60                  
Glu Ala Tyr Thr Phe Glu Gly Ala Arg Tyr Tyr Ile Asn His Asn Glu
65                  70                  75                  80  
Arg Lys Val Thr Cys Lys His Pro Val Thr Gly Gln Pro Ser Gln Asp
                85                  90                  95      
Asn Cys Ile Phe Val Val Asn Glu Gln Thr Val Ala Thr Met Thr Ser
            100                 105                 110         
Glu Glu Lys Lys Glu Arg Pro Ile Ser Met Ile Asn Glu Ala Ser Asn
        115                 120                 125             
Tyr Asn Val Thr Ser Asp Tyr Ala Val His Pro Met Ser Pro Val Gly
    130                 135                 140                 
Arg Thr Ser Arg Ala Ser Lys Lys Val His Asn Phe Gly Lys Arg Ser
145                 150                 155                 160 
Asn Ser Ile Lys Arg Asn Pro Asn Ala Pro Val Val Arg Arg Gly Trp
                165                 170                 175     
Leu Tyr Lys Gln Asp Ser Thr Gly Met Lys Leu Trp Lys Lys Arg Trp
            180                 185                 190         
Phe Val Leu Ser Asp Leu Cys Leu Phe Tyr Tyr Arg Asp Glu Lys Glu
        195                 200                 205             
Glu Gly Ile Leu Gly Ser Ile Leu Leu Pro Ser Phe Gln Ile Ala Leu
    210                 215                 220                 
Leu Thr Ser Glu Asp His Ile Asn Arg Lys Tyr Ala Phe Lys Ala Ala
225                 230                 235                 240 
His Pro Asn Met Arg Thr Tyr Tyr Phe Cys Thr Asp Thr Gly Lys Glu
                245                 250                 255     
Met Glu Leu Trp Met Lys Ala Met Leu Asp Ala Ala Leu Val Gln Thr
            260                 265                 270         
Glu Pro Val Lys Arg Val Asp Lys Ile Thr Ser Glu Asn Ala Pro Thr
        275                 280                 285             
Lys Glu Thr Asn Asn Ile Pro Asn His Arg Val Leu Ile Lys Pro Glu
    290                 295                 300                 
Ile Gln Asn Asn Gln Lys Asn Lys Glu Met Ser Lys Ile Glu Glu Lys
305                 310                 315                 320 
Lys Ala Leu Glu Ala Glu Lys Tyr Gly Phe Gln Lys Asp Gly Gln Asp
                325                 330                 335     
Arg Pro Leu Thr Lys Ile Asn Ser Val Lys Leu Asn Ser Leu Pro Ser
            340                 345                 350         
Glu Tyr Glu Ser Gly Ser Ala Cys Pro Ala Gln Thr Val His Tyr Arg
        355                 360                 365             
Pro Ile Asn Leu Ser Ser Ser Glu Asn Lys Ile Val Asn Val Ser Leu
    370                 375                 380                 
Ala Asp Leu Arg Gly Gly Asn Arg Pro Asn Thr Gly Pro Leu Tyr Thr
385                 390                 395                 400 
Glu Ala Asp Arg Val Ile Gln Arg Thr Asn Ser Met Gln Gln Leu Glu
                405                 410                 415     
Gln Trp Ile Lys Ile Gln Lys Gly Arg Gly His Glu Glu Glu Thr Arg
            420                 425                 430         
Gly Val Ile Ser Tyr Gln Thr Leu Pro Arg Asn Met Pro Ser His Arg
        435                 440                 445             
Ala Gln Ile Met Ala Arg Tyr Pro Glu Gly Tyr Arg Thr Leu Pro Arg
    450                 455                 460                 
Asn Ser Lys Thr Arg Pro Glu Ser Ile Cys Ser Val Thr Pro Ser Thr
465                 470                 475                 480 
His Asp Lys Thr Leu Gly Pro Gly Ala Glu Glu Lys Arg Arg Ser Met
                485                 490                 495     
Arg Asp Asp Thr Met Trp Gln Leu Tyr Glu Trp Gln Gln Arg Gln Phe
            500                 505                 510         
Tyr Asn Lys Gln Ser Thr Leu Pro Arg His Ser Thr Leu Ser Ser Pro
        515                 520                 525             
Lys Thr Met Val Asn Ile Ser Asp Gln Thr Met His Ser Ile Pro Thr
    530                 535                 540                 
Ser Pro Ser His Gly Ser Ile Ala Ala Tyr Gln Gly Tyr Ser Pro Gln
545                 550                 555                 560 
Arg Thr Tyr Arg Ser Glu Val Ser Ser Pro Ile Gln Arg Gly Asp Val
                565                 570                 575     
Thr Ile Asp Arg Arg His Arg Ala His His Pro Lys His Val Tyr Val
            580                 585                 590         
Pro Asp Arg Arg Ser Val Pro Ala Gly Leu Thr Leu Gln Ser Val Ser
        595                 600                 605             
Pro Gln Ser Leu Gln Gly Lys Thr Pro Glu Glu Leu Thr Leu Leu Leu
    610                 615                 620                 
Ile Lys Leu Arg Arg Gln Gln Ala Glu Leu Ser Ser Ile Arg Glu His
625                 630                 635                 640 
Thr Leu Ala Gln Leu Met Gln Leu Lys Leu Glu Ala His Ser Pro Lys
                645                 650                 655     
Asn Glu Ile Leu Ser His His Leu Gln Arg Asn Thr Ile Tyr Leu Asp
            660                 665                 670         
His Gln Leu Ser Gln Asp Glu Gly Arg Gly Thr Leu Tyr Lys Tyr Arg
        675                 680                 685             
Pro Glu Glu Val Asp Ile Asp Ala Lys Leu Ser Arg Leu Cys Glu Gln
    690                 695                 700                 
Asp Lys Val Val His Ala Leu Glu Glu Lys Leu Gln Gln Leu His Lys
705                 710                 715                 720 
Glu Lys Tyr Thr Leu Glu Gln Ala Leu Leu Ser Ala Ser Gln Glu Ile
                725                 730                 735     
Glu Met His Ala Asp Asn Pro Ala Ala Ile Gln Thr Val Val Leu Gln
            740                 745                 750         
Arg Asp Asp Leu Gln Asn Gly Leu Leu Ser Thr Cys Arg Glu Leu Ser
        755                 760                 765             
Arg Ala Thr Ala Glu Leu Glu Arg Ala Trp Arg Glu Tyr Asp Lys Leu
    770                 775                 780                 
Glu Tyr Asp Val Thr Val Thr Arg Asn Gln Met Gln Glu Gln Leu Asp
785                 790                 795                 800 
His Leu Gly Glu Val Gln Thr Glu Ser Ala Gly Ile Gln Arg Ala Gln
                805                 810                 815     
Ile Gln Lys Glu Leu Trp Arg Ile Gln Asp Val Met Glu Gly Leu Ser
            820                 825                 830         
Lys His Lys Gln Gln Arg Gly Thr Thr Glu Ile Gly Met Ile Gly Ser
        835                 840                 845             
Lys Pro Phe Ser Thr Val Lys Tyr Lys Asn Glu Gly Pro Asp Tyr Arg
    850                 855                 860                 
Leu Tyr Lys Ser Glu Pro Glu Leu Thr Thr Val Ala Glu Val Asp Glu
865                 870                 875                 880 
Ser Asn Gly Glu Glu Lys Ser Glu Pro Val Ser Glu Ile Glu Thr Ser
                885                 890                 895     
Val Val Lys Gly Ser His Phe Pro Val Gly Val Val Pro Pro Arg Ala
            900                 905                 910         
Lys Ser Pro Thr Pro Glu Ser Ser Thr Ile Ala Ser Tyr Val Thr Leu
        915                 920                 925             
Arg Lys Thr Lys Lys Met Met Asp Leu Arg Thr Glu Arg Pro Arg Ser
    930                 935                 940                 
Ala Val Glu Gln Leu Cys Leu Ala Glu Ser Thr Arg Pro Arg Met Thr
945                 950                 955                 960 
Val Glu Glu Gln Met Glu Arg Ile Arg Arg His Gln Gln Ala Cys Leu
                965                 970                 975     
Arg Glu Lys Lys Lys Gly Leu Asn Val Ile Gly Ala Ser Asp Gln Ser
            980                 985                 990         
Pro Leu Gln Ser Pro Ser Asn Leu Arg Asp Asn Pro Phe Arg Thr Thr
        995                 1000                1005            
Gln Thr Arg Arg Arg Asp Asp Lys Glu Leu Asp Thr Ala Ile Arg Glu
    1010                1015                1020                
Asn Asp Val Lys Pro Asp His Glu Thr Pro Ala Thr Glu Ile Val Gln
1025                1030                1035                1040
Leu Lys Glu Thr Glu Pro Gln Asn Val Asp Phe Ser Lys Glu Leu Lys
                1045                1050                1055    
Lys Thr Glu Asn Ile Ser Tyr Glu Met Leu Phe Glu Pro Glu Pro Asn
            1060                1065                1070        
Gly Val Asn Ser Val Glu Met Met Asp Lys Glu Arg Asn Lys Asp Lys
        1075                1080                1085            
Met Pro Glu Asp Val Thr Phe Ser Pro Gln Asp Glu Thr Gln Thr Ala
    1090                1095                1100                
Asn His Lys Pro Glu Glu His Pro Glu Glu Asn Thr Lys Asn Ser Val
1105                1110                1115                1120
Asp Glu Gln Glu Glu Thr Val Ile Ser Tyr Glu Ser Thr Pro Glu Val
                1125                1130                1135    
Ser Arg Gly Asn Gln Thr Met Ala Val Lys Ser Leu Ser Pro Ser Pro
            1140                1145                1150        
Glu Ser Ser Ala Ser Pro Val Pro Ser Thr Gln Pro Gln Leu Thr Glu
        1155                1160                1165            
Gly Ser His Phe Met Cys Val
    1170                1175


<210> 6283
<211> 1062
<212> PRT
<213> Homo sapiens

<400> 6283
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu
 1               5                  10                  15      
Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr
            20                  25                  30          
Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp
        35                  40                  45              
Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp
    50                  55                  60                  
Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His
65                  70                  75                  80  
Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala
                85                  90                  95      
Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg
            100                 105                 110         
Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys
        115                 120                 125             
Thr Glu Ala Gln Ala Phe Thr Glu Thr Lys Gly Asn Val Ile Cys Leu
    130                 135                 140                 
Gly Lys Glu Val Phe Lys Gly Lys Lys Pro Asp Lys Asp Asn Arg Cys
145                 150                 155                 160 
Arg Tyr Ile Leu Lys Thr Lys Phe Arg Glu Met Trp Lys Ser Trp Pro
                165                 170                 175     
Gly Asp Ser Lys Glu Val Gln Val Met Ala Glu Arg Tyr Lys Met Leu
            180                 185                 190         
Ile Pro Phe Ser Asn Pro Arg Val Leu Pro Gly Pro Phe Ser Tyr Thr
        195                 200                 205             
Val Val Leu Tyr Gly Pro Ala Gly Leu Gly Lys Thr Thr Leu Ala Gln
    210                 215                 220                 
Lys Leu Met Leu Asp Trp Ala Glu Asp Asn Leu Ile His Lys Phe Lys
225                 230                 235                 240 
Tyr Ala Phe Tyr Leu Ser Cys Arg Glu Leu Ser Arg Leu Gly Pro Cys
                245                 250                 255     
Ser Phe Ala Glu Leu Val Phe Arg Asp Trp Pro Glu Leu Gln Asp Asp
            260                 265                 270         
Ile Pro His Ile Leu Ala Gln Ala Arg Lys Ile Leu Phe Val Ile Asp
        275                 280                 285             
Gly Phe Asp Glu Leu Gly Ala Ala Pro Gly Ala Leu Ile Glu Asp Ile
    290                 295                 300                 
Cys Gly Asp Trp Glu Lys Lys Lys Pro Val Pro Val Leu Leu Gly Ser
305                 310                 315                 320 
Leu Leu Asn Arg Val Met Leu Pro Lys Ala Ala Leu Leu Val Thr Thr
                325                 330                 335     
Arg Pro Arg Ala Leu Arg Asp Leu Arg Ile Leu Ala Glu Glu Pro Ile
            340                 345                 350         
Tyr Ile Arg Val Glu Gly Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe
        355                 360                 365             
Leu Arg His Phe Gly Asp Glu Asp Gln Ala Met Arg Ala Phe Glu Leu
    370                 375                 380                 
Met Arg Ser Asn Ala Ala Leu Phe Gln Leu Gly Ser Ala Pro Ala Val
385                 390                 395                 400 
Cys Trp Ile Val Cys Thr Thr Leu Lys Leu Gln Met Glu Lys Gly Glu
                405                 410                 415     
Asp Pro Val Pro Thr Cys Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe
            420                 425                 430         
Leu Cys Ser Arg Phe Pro Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg
        435                 440                 445             
Thr Leu Ser Leu Leu Ala Ala Gln Gly Leu Trp Ala Gln Thr Ser Val
    450                 455                 460                 
Leu His Arg Glu Asp Leu Glu Arg Leu Gly Val Gln Glu Ser Asp Leu
465                 470                 475                 480 
Arg Leu Phe Leu Asp Gly Asp Ile Leu Arg Gln Asp Arg Val Ser Lys
                485                 490                 495     
Gly Cys Tyr Ser Phe Ile His Leu Ser Phe Gln Gln Phe Leu Thr Ala
            500                 505                 510         
Leu Phe Tyr Thr Leu Glu Lys Glu Glu Glu Glu Asp Arg Asp Gly His
        515                 520                 525             
Thr Trp Asp Ile Gly Asp Val Gln Lys Leu Leu Ser Gly Val Glu Arg
    530                 535                 540                 
Leu Arg Asn Pro Asp Leu Ile Gln Ala Gly Tyr Tyr Ser Phe Gly Leu
545                 550                 555                 560 
Ala Asn Glu Lys Arg Ala Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg
                565                 570                 575     
Met Ser Pro Asp Ile Lys Gln Glu Leu Leu Arg Cys Asp Ile Ser Cys
            580                 585                 590         
Lys Gly Gly His Ser Thr Val Thr Asp Leu Gln Glu Leu Leu Gly Cys
        595                 600                 605             
Leu Tyr Glu Ser Gln Glu Glu Glu Leu Val Lys Glu Val Met Ala Gln
    610                 615                 620                 
Phe Lys Glu Ile Ser Leu His Leu Asn Ala Val Asp Val Val Pro Ser
625                 630                 635                 640 
Ser Phe Cys Val Lys His Cys Arg Asn Leu Gln Lys Met Ser Leu Gln
                645                 650                 655     
Val Ile Lys Glu Asn Leu Pro Glu Asn Val Thr Ala Ser Glu Ser Asp
            660                 665                 670         
Ala Glu Val Glu Arg Ser Gln Asp Asp Gln His Met Leu Pro Phe Trp
        675                 680                 685             
Thr Asp Leu Cys Ser Ile Phe Gly Ser Asn Lys Asp Leu Met Gly Leu
    690                 695                 700                 
Ala Ile Asn Asp Ser Phe Leu Ser Ala Ser Leu Val Arg Ile Leu Cys
705                 710                 715                 720 
Glu Gln Ile Ala Ser Asp Thr Cys His Leu Gln Arg Val Val Phe Lys
                725                 730                 735     
Asn Ile Ser Pro Ala Asp Ala His Arg Asn Leu Cys Leu Ala Leu Arg
            740                 745                 750         
Gly His Lys Thr Val Thr Tyr Leu Thr Leu Gln Gly Asn Asp Gln Asp
        755                 760                 765             
Asp Met Phe Pro Ala Leu Cys Glu Val Leu Arg His Pro Glu Cys Asn
    770                 775                 780                 
Leu Arg Tyr Leu Gly Leu Val Ser Cys Ser Ala Thr Thr Gln Gln Trp
785                 790                 795                 800 
Ala Asp Leu Ser Leu Ala Leu Glu Val Asn Gln Ser Leu Thr Cys Val
                805                 810                 815     
Asn Leu Ser Asp Asn Glu Leu Leu Asp Glu Gly Ala Lys Leu Leu Tyr
            820                 825                 830         
Thr Thr Leu Arg His Pro Lys Cys Phe Leu Gln Arg Leu Ser Leu Glu
        835                 840                 845             
Asn Cys His Leu Thr Glu Ala Asn Cys Lys Asp Leu Ala Ala Val Leu
    850                 855                 860                 
Val Val Ser Arg Glu Leu Thr His Leu Cys Leu Ala Lys Asn Pro Ile
865                 870                 875                 880 
Gly Asn Thr Gly Val Lys Phe Leu Cys Glu Gly Leu Arg Tyr Pro Glu
                885                 890                 895     
Cys Lys Leu Gln Thr Leu Val Leu Trp Asn Cys Asp Ile Thr Ser Asp
            900                 905                 910         
Gly Cys Cys Asp Leu Thr Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu
        915                 920                 925             
Cys Leu Asp Leu Gly Leu Asn His Ile Gly Val Lys Gly Met Lys Phe
    930                 935                 940                 
Leu Cys Glu Ala Leu Arg Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp
945                 950                 955                 960 
Leu Trp Gly Cys Ser Ile Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser
                965                 970                 975     
Ala Leu Ser Cys Asn Gln Ser Leu Val Thr Leu Asp Leu Gly Gln Asn
            980                 985                 990         
Pro Leu Gly Ser Ser Gly Val Lys Met Leu Phe Glu Thr Leu Thr Cys
        995                 1000                1005            
Ser Ser Gly Thr Leu Arg Thr Leu Arg Leu Lys Ile Asp Asp Phe Asn
    1010                1015                1020                
Asp Glu Leu Asn Lys Leu Leu Glu Glu Ile Glu Glu Lys Asn Pro Gln
1025                1030                1035                1040
Leu Ile Ile Asp Thr Glu Lys His His Pro Trp Ala Glu Arg Pro Ser
                1045                1050                1055    
Ser His Asp Phe Met Ile
            1060        


<210> 6284
<211> 1040
<212> PRT
<213> Homo sapiens

<400> 6284
Met Val Ser Ser Ala Gln Met Gly Phe Asn Leu Gln Ala Leu Leu Glu
 1               5                  10                  15      
Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Tyr Leu Ile Thr Thr
            20                  25                  30          
Phe Ser Leu Ala His Glu Leu Gln Lys Ile Pro His Lys Glu Val Asp
        35                  40                  45              
Lys Ala Asp Gly Lys Gln Leu Val Glu Ile Leu Thr Thr His Cys Asp
    50                  55                  60                  
Ser Tyr Trp Val Glu Met Ala Ser Leu Gln Val Phe Glu Lys Met His
65                  70                  75                  80  
Arg Met Asp Leu Ser Glu Arg Ala Lys Asp Glu Val Arg Glu Ala Ala
                85                  90                  95      
Leu Lys Ser Phe Asn Lys Arg Lys Pro Leu Ser Leu Gly Ile Thr Arg
            100                 105                 110         
Lys Glu Arg Pro Pro Leu Asp Val Asp Glu Met Leu Glu Arg Phe Lys
        115                 120                 125             
Thr Glu Ala Gln Asp Lys Asp Asn Arg Cys Arg Tyr Ile Leu Lys Thr
    130                 135                 140                 
Lys Phe Arg Glu Met Trp Lys Ser Trp Pro Gly Asp Ser Lys Glu Val
145                 150                 155                 160 
Gln Val Met Ala Glu Arg Tyr Lys Met Leu Ile Pro Phe Ser Asn Pro
                165                 170                 175     
Arg Val Leu Pro Gly Pro Phe Ser Tyr Thr Val Val Leu Tyr Gly Pro
            180                 185                 190         
Ala Gly Leu Gly Lys Thr Thr Leu Ala Gln Lys Leu Met Leu Asp Trp
        195                 200                 205             
Ala Glu Asp Asn Leu Ile His Lys Phe Lys Tyr Ala Phe Tyr Leu Ser
    210                 215                 220                 
Cys Arg Glu Leu Ser Arg Leu Gly Pro Cys Ser Phe Ala Glu Leu Val
225                 230                 235                 240 
Phe Arg Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro His Ile Leu Ala
                245                 250                 255     
Gln Ala Arg Lys Ile Leu Phe Val Ile Asp Gly Phe Asp Glu Leu Gly
            260                 265                 270         
Ala Ala Pro Gly Ala Leu Ile Glu Asp Ile Cys Gly Asp Trp Glu Lys
        275                 280                 285             
Lys Lys Pro Val Pro Val Leu Leu Gly Ser Leu Leu Asn Arg Val Met
    290                 295                 300                 
Leu Pro Lys Ala Ala Leu Leu Val Thr Thr Arg Pro Arg Ala Leu Arg
305                 310                 315                 320 
Asp Leu Arg Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val Glu Gly
                325                 330                 335     
Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His Phe Gly Asp
            340                 345                 350         
Glu Asp Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser Asn Ala Ala
        355                 360                 365             
Leu Phe Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile Val Cys Thr
    370                 375                 380                 
Thr Leu Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val Pro Thr Cys
385                 390                 395                 400 
Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser Arg Phe Pro
                405                 410                 415     
Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser Leu Leu Ala
            420                 425                 430         
Ala Gln Gly Leu Trp Ala Gln Thr Ser Val Leu His Arg Glu Asp Leu
        435                 440                 445             
Glu Arg Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe Leu Asp Gly
    450                 455                 460                 
Asp Ile Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr Ser Phe Ile
465                 470                 475                 480 
His Leu Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr Thr Leu Glu
                485                 490                 495     
Lys Glu Glu Glu Glu Asp Arg Asp Gly His Thr Trp Asp Ile Gly Asp
            500                 505                 510         
Val Gln Lys Leu Leu Ser Gly Val Glu Arg Leu Arg Asn Pro Asp Leu
        515                 520                 525             
Ile Gln Ala Gly Tyr Tyr Ser Phe Gly Leu Ala Asn Glu Lys Arg Ala
    530                 535                 540                 
Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro Asp Ile Lys
545                 550                 555                 560 
Gln Glu Leu Leu Arg Cys Asp Ile Ser Cys Lys Gly Gly His Ser Thr
                565                 570                 575     
Val Thr Asp Leu Gln Glu Leu Leu Gly Cys Leu Tyr Glu Ser Gln Glu
            580                 585                 590         
Glu Glu Leu Val Lys Glu Val Met Ala Gln Phe Lys Glu Ile Ser Leu
        595                 600                 605             
His Leu Asn Ala Val Asp Val Val Pro Ser Ser Phe Cys Val Lys His
    610                 615                 620                 
Cys Arg Asn Leu Gln Lys Met Ser Leu Gln Val Ile Lys Glu Asn Leu
625                 630                 635                 640 
Pro Glu Asn Val Thr Ala Ser Glu Ser Asp Ala Glu Val Glu Arg Ser
                645                 650                 655     
Gln Asp Asp Gln His Met Leu Pro Phe Trp Thr Asp Leu Cys Ser Ile
            660                 665                 670         
Phe Gly Ser Asn Lys Asp Leu Met Gly Leu Ala Ile Asn Asp Ser Phe
        675                 680                 685             
Leu Ser Ala Ser Leu Val Arg Ile Leu Cys Glu Gln Ile Ala Ser Asp
    690                 695                 700                 
Thr Cys His Leu Gln Arg Val Val Phe Lys Asn Ile Ser Pro Ala Asp
705                 710                 715                 720 
Ala His Arg Asn Leu Cys Leu Ala Leu Arg Gly His Lys Thr Val Thr
                725                 730                 735     
Tyr Leu Thr Leu Gln Gly Asn Asp Gln Asp Asp Met Phe Pro Ala Leu
            740                 745                 750         
Cys Glu Val Leu Arg His Pro Glu Cys Asn Leu Arg Tyr Leu Gly Leu
        755                 760                 765             
Val Ser Cys Ser Ala Thr Thr Gln Gln Trp Ala Asp Leu Ser Leu Ala
    770                 775                 780                 
Leu Glu Val Asn Gln Ser Leu Thr Cys Val Asn Leu Ser Asp Asn Glu
785                 790                 795                 800 
Leu Leu Asp Glu Gly Ala Lys Leu Leu Tyr Thr Thr Leu Arg His Pro
                805                 810                 815     
Lys Cys Phe Leu Gln Arg Leu Ser Leu Glu Asn Cys His Leu Thr Glu
            820                 825                 830         
Ala Asn Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Arg Glu Leu
        835                 840                 845             
Thr His Leu Cys Leu Ala Lys Asn Pro Ile Gly Asn Thr Gly Val Lys
    850                 855                 860                 
Phe Leu Cys Glu Gly Leu Arg Tyr Pro Glu Cys Lys Leu Gln Thr Leu
865                 870                 875                 880 
Val Leu Trp Asn Cys Asp Ile Thr Ser Asp Gly Cys Cys Asp Leu Thr
                885                 890                 895     
Lys Leu Leu Gln Glu Lys Ser Ser Leu Leu Cys Leu Asp Leu Gly Leu
            900                 905                 910         
Asn His Ile Gly Val Lys Gly Met Lys Phe Leu Cys Glu Ala Leu Arg
        915                 920                 925             
Lys Pro Leu Cys Asn Leu Arg Cys Leu Trp Leu Trp Gly Cys Ser Ile
    930                 935                 940                 
Pro Pro Phe Ser Cys Glu Asp Leu Cys Ser Ala Leu Ser Cys Asn Gln
945                 950                 955                 960 
Ser Leu Val Thr Leu Asp Leu Gly Gln Asn Pro Leu Gly Ser Ser Gly
                965                 970                 975     
Val Lys Met Leu Phe Glu Thr Leu Thr Cys Ser Ser Gly Thr Leu Arg
            980                 985                 990         
Thr Leu Arg Leu Lys Ile Asp Asp Phe Asn Asp Glu Leu Asn Lys Leu
        995                 1000                1005            
Leu Glu Glu Ile Glu Glu Lys Asn Pro Gln Leu Ile Ile Asp Thr Glu
    1010                1015                1020                
Lys His His Pro Trp Ala Glu Arg Pro Ser Ser His Asp Phe Met Ile
1025                1030                1035                1040


<210> 6285
<211> 79
<212> PRT
<213> Homo sapiens

<400> 6285
Arg Leu Leu Pro Asp Ser Ser Ser Gly Cys Pro Arg Ala Ser Phe Gln
 1               5                  10                  15      
Pro Ala Arg Pro His Arg Ala Arg His Pro His Trp Arg Glu Phe Asp
            20                  25                  30          
Leu Met Phe His Lys Ala Leu Tyr Leu Arg Arg Arg Gly Met Val Cys
        35                  40                  45              
Leu Gln Ser Val Cys Arg Ser Asp Cys Ser Gly Lys Glu Asn Lys Gly
    50                  55                  60                  
Asp Asn Asn Cys Asn His Asn Asp Pro Leu Tyr Glu Asn Ser Ser
65                  70                  75                  


<210> 6286
<211> 803
<212> PRT
<213> Homo sapiens

<400> 6286
Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro
 1               5                  10                  15      
Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr
            20                  25                  30          
Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys
        35                  40                  45              
Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn
    50                  55                  60                  
Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys
65                  70                  75                  80  
Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg
                85                  90                  95      
Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val
            100                 105                 110         
Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala
        115                 120                 125             
Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys
    130                 135                 140                 
Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys
145                 150                 155                 160 
Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala
                165                 170                 175     
Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly
            180                 185                 190         
Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp
        195                 200                 205             
Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys
    210                 215                 220                 
Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys
225                 230                 235                 240 
Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys
                245                 250                 255     
Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile
            260                 265                 270         
Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe
        275                 280                 285             
Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp
    290                 295                 300                 
Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser
305                 310                 315                 320 
Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu
                325                 330                 335     
Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg
            340                 345                 350         
Ser Arg Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser
        355                 360                 365             
Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val
    370                 375                 380                 
Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu
385                 390                 395                 400 
Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile
                405                 410                 415     
Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser
            420                 425                 430         
Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu
        435                 440                 445             
Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val
    450                 455                 460                 
Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg
465                 470                 475                 480 
Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala
                485                 490                 495     
Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser
            500                 505                 510         
Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr
        515                 520                 525             
Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp
    530                 535                 540                 
Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser
545                 550                 555                 560 
Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys
                565                 570                 575     
Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys
            580                 585                 590         
Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys
        595                 600                 605             
Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro
    610                 615                 620                 
Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro
625                 630                 635                 640 
Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser
                645                 650                 655     
Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Gly Ala Cys
            660                 665                 670         
Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn
        675                 680                 685             
Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu
    690                 695                 700                 
Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser
705                 710                 715                 720 
Lys Leu Cys Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn
                725                 730                 735     
Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr
            740                 745                 750         
Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys
        755                 760                 765             
Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys
    770                 775                 780                 
Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe
785                 790                 795                 800 
Lys Lys Phe
            


<210> 6287
<211> 846
<212> PRT
<213> Homo sapiens

<400> 6287
Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro
 1               5                  10                  15      
Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr
            20                  25                  30          
Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys
        35                  40                  45              
Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn
    50                  55                  60                  
Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys
65                  70                  75                  80  
Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg
                85                  90                  95      
Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val
            100                 105                 110         
Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala
        115                 120                 125             
Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys
    130                 135                 140                 
Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys
145                 150                 155                 160 
Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala
                165                 170                 175     
Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly
            180                 185                 190         
Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp
        195                 200                 205             
Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys
    210                 215                 220                 
Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys
225                 230                 235                 240 
Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys
                245                 250                 255     
Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile
            260                 265                 270         
Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe
        275                 280                 285             
Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp
    290                 295                 300                 
Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser
305                 310                 315                 320 
Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu
                325                 330                 335     
Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg
            340                 345                 350         
Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser
        355                 360                 365             
Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val
    370                 375                 380                 
Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu
385                 390                 395                 400 
Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile
                405                 410                 415     
Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser
            420                 425                 430         
Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu
        435                 440                 445             
Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val
    450                 455                 460                 
Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg
465                 470                 475                 480 
Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala
                485                 490                 495     
Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser
            500                 505                 510         
Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr
        515                 520                 525             
Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp
    530                 535                 540                 
Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser
545                 550                 555                 560 
Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys
                565                 570                 575     
Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys
            580                 585                 590         
Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys
        595                 600                 605             
Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro
    610                 615                 620                 
Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro
625                 630                 635                 640 
Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser
                645                 650                 655     
Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Gly Ala Cys
            660                 665                 670         
Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn
        675                 680                 685             
Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu
    690                 695                 700                 
Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser
705                 710                 715                 720 
Lys Leu Cys Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn
                725                 730                 735     
Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr
            740                 745                 750         
Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys
        755                 760                 765             
Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys
    770                 775                 780                 
Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe
785                 790                 795                 800 
Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro
                805                 810                 815     
Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe
            820                 825                 830         
Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln
        835                 840                 845     


<210> 6288
<211> 1972
<212> PRT
<213> Homo sapiens

<400> 6288
Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val
 1               5                  10                  15      
Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala
            20                  25                  30          
Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala
        35                  40                  45              
Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu
    50                  55                  60                  
Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn
65                  70                  75                  80  
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu
                85                  90                  95      
Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly
            100                 105                 110         
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr
        115                 120                 125             
Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly
    130                 135                 140                 
Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr
145                 150                 155                 160 
Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys
                165                 170                 175     
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile
            180                 185                 190         
Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr
        195                 200                 205             
Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile
    210                 215                 220                 
Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser
225                 230                 235                 240 
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile
                245                 250                 255     
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile
            260                 265                 270         
Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile
        275                 280                 285             
Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe
    290                 295                 300                 
Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala
305                 310                 315                 320 
Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met
                325                 330                 335     
Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser
            340                 345                 350         
Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp
        355                 360                 365             
Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu
    370                 375                 380                 
Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg
385                 390                 395                 400 
Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln
                405                 410                 415     
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu
            420                 425                 430         
Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His
        435                 440                 445             
Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu
    450                 455                 460                 
Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn
465                 470                 475                 480 
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln
                485                 490                 495     
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly
            500                 505                 510         
Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro
        515                 520                 525             
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala
    530                 535                 540                 
Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His
545                 550                 555                 560 
Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser
                565                 570                 575     
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu
            580                 585                 590         
Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn
        595                 600                 605             
Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg
    610                 615                 620                 
Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro
625                 630                 635                 640 
Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu
                645                 650                 655     
Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr
            660                 665                 670         
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly
        675                 680                 685             
Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val
    690                 695                 700                 
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val
705                 710                 715                 720 
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile
                725                 730                 735     
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys
            740                 745                 750         
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile
        755                 760                 765             
Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu
    770                 775                 780                 
Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr
785                 790                 795                 800 
Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met
                805                 810                 815     
Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp
            820                 825                 830         
Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr
        835                 840                 845             
Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr
    850                 855                 860                 
Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln
865                 870                 875                 880 
Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu
                885                 890                 895     
Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg
            900                 905                 910         
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu
        915                 920                 925             
Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu
    930                 935                 940                 
Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu
945                 950                 955                 960 
Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala
                965                 970                 975     
Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp
            980                 985                 990         
Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile
        995                 1000                1005            
Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn
    1010                1015                1020                
Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu
1025                1030                1035                1040
Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu
                1045                1050                1055    
Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala
            1060                1065                1070        
Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys
        1075                1080                1085            
Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala
    1090                1095                1100                
Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile
1105                1110                1115                1120
Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys
                1125                1130                1135    
Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys
            1140                1145                1150        
Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu
        1155                1160                1165            
Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp
    1170                1175                1180                
Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys
1185                1190                1195                1200
His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys
                1205                1210                1215    
Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu
            1220                1225                1230        
Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln
        1235                1240                1245            
Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu
    1250                1255                1260                
Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp
1265                1270                1275                1280
Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu
                1285                1290                1295    
Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser
            1300                1305                1310        
Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr
        1315                1320                1325            
Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu
    1330                1335                1340                
Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln
1345                1350                1355                1360
Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser
                1365                1370                1375    
Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu
            1380                1385                1390        
Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr
        1395                1400                1405            
Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg
    1410                1415                1420                
Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg
1425                1430                1435                1440
Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu
                1445                1450                1455    
Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp
            1460                1465                1470        
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu
        1475                1480                1485            
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg
    1490                1495                1500                
Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys
1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala
                1525                1530                1535    
Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu
            1540                1545                1550        
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn
        1555                1560                1565            
Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp
    1570                1575                1580                
Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu
1585                1590                1595                1600
Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala
                1605                1610                1615    
Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln
            1620                1625                1630        
Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg
        1635                1640                1645            
Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala
    1650                1655                1660                
Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys
1665                1670                1675                1680
Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu
                1685                1690                1695    
Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu
            1700                1705                1710        
Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln
        1715                1720                1725            
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu
    1730                1735                1740                
Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg
1745                1750                1755                1760
Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu
                1765                1770                1775    
Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg
            1780                1785                1790        
Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val
        1795                1800                1805            
Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala
    1810                1815                1820                
Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala
1825                1830                1835                1840
Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu
                1845                1850                1855    
Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala
            1860                1865                1870        
Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu
        1875                1880                1885            
Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln
    1890                1895                1900                
Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu
1905                1910                1915                1920
Val Asn Ala Leu Lys Ser Lys Leu Arg Arg Gly Asn Glu Thr Ser Phe
                1925                1930                1935    
Val Pro Ser Arg Arg Ser Gly Gly Arg Arg Val Ile Glu Asn Ala Asp
            1940                1945                1950        
Gly Ser Glu Glu Glu Thr Asp Thr Arg Asp Ala Asp Phe Asn Gly Thr
        1955                1960                1965            
Lys Ala Ser Glu
    1970        


<210> 6289
<211> 1938
<212> PRT
<213> Homo sapiens

<400> 6289
Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val
 1               5                  10                  15      
Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala
            20                  25                  30          
Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala
        35                  40                  45              
Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu
    50                  55                  60                  
Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn
65                  70                  75                  80  
Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu
                85                  90                  95      
Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly
            100                 105                 110         
Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr
        115                 120                 125             
Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly
    130                 135                 140                 
Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr
145                 150                 155                 160 
Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys
                165                 170                 175     
Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile
            180                 185                 190         
Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr
        195                 200                 205             
Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile
    210                 215                 220                 
Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser
225                 230                 235                 240 
Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile
                245                 250                 255     
Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile
            260                 265                 270         
Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile
        275                 280                 285             
Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe
    290                 295                 300                 
Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala
305                 310                 315                 320 
Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met
                325                 330                 335     
Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser
            340                 345                 350         
Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp
        355                 360                 365             
Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu
    370                 375                 380                 
Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg
385                 390                 395                 400 
Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln
                405                 410                 415     
Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu
            420                 425                 430         
Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His
        435                 440                 445             
Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu
    450                 455                 460                 
Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn
465                 470                 475                 480 
Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln
                485                 490                 495     
Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly
            500                 505                 510         
Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro
        515                 520                 525             
Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala
    530                 535                 540                 
Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His
545                 550                 555                 560 
Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser
                565                 570                 575     
Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu
            580                 585                 590         
Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn
        595                 600                 605             
Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg
    610                 615                 620                 
Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro
625                 630                 635                 640 
Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu
                645                 650                 655     
Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr
            660                 665                 670         
Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly
        675                 680                 685             
Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val
    690                 695                 700                 
Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val
705                 710                 715                 720 
Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile
                725                 730                 735     
Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys
            740                 745                 750         
Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile
        755                 760                 765             
Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu
    770                 775                 780                 
Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr
785                 790                 795                 800 
Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met
                805                 810                 815     
Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp
            820                 825                 830         
Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr
        835                 840                 845             
Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr
    850                 855                 860                 
Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln
865                 870                 875                 880 
Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu
                885                 890                 895     
Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg
            900                 905                 910         
Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu
        915                 920                 925             
Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu
    930                 935                 940                 
Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu
945                 950                 955                 960 
Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala
                965                 970                 975     
Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp
            980                 985                 990         
Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile
        995                 1000                1005            
Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn
    1010                1015                1020                
Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu
1025                1030                1035                1040
Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu
                1045                1050                1055    
Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala
            1060                1065                1070        
Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys
        1075                1080                1085            
Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala
    1090                1095                1100                
Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile
1105                1110                1115                1120
Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys
                1125                1130                1135    
Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys
            1140                1145                1150        
Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu
        1155                1160                1165            
Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp
    1170                1175                1180                
Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys
1185                1190                1195                1200
His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys
                1205                1210                1215    
Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu
            1220                1225                1230        
Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln
        1235                1240                1245            
Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu
    1250                1255                1260                
Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp
1265                1270                1275                1280
Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu
                1285                1290                1295    
Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser
            1300                1305                1310        
Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr
        1315                1320                1325            
Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu
    1330                1335                1340                
Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln
1345                1350                1355                1360
Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser
                1365                1370                1375    
Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu
            1380                1385                1390        
Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr
        1395                1400                1405            
Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg
    1410                1415                1420                
Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg
1425                1430                1435                1440
Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu
                1445                1450                1455    
Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp
            1460                1465                1470        
Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu
        1475                1480                1485            
Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg
    1490                1495                1500                
Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys
1505                1510                1515                1520
Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala
                1525                1530                1535    
Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu
            1540                1545                1550        
Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn
        1555                1560                1565            
Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp
    1570                1575                1580                
Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu
1585                1590                1595                1600
Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala
                1605                1610                1615    
Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln
            1620                1625                1630        
Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg
        1635                1640                1645            
Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala
    1650                1655                1660                
Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys
1665                1670                1675                1680
Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu
                1685                1690                1695    
Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu
            1700                1705                1710        
Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln
        1715                1720                1725            
Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu
    1730                1735                1740                
Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg
1745                1750                1755                1760
Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu
                1765                1770                1775    
Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg
            1780                1785                1790        
Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val
        1795                1800                1805            
Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala
    1810                1815                1820                
Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala
1825                1830                1835                1840
Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu
                1845                1850                1855    
Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala
            1860                1865                1870        
Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu
        1875                1880                1885            
Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln
    1890                1895                1900                
Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu
1905                1910                1915                1920
Val Asn Ala Leu Lys Ser Lys Leu Arg Gly Pro Pro Pro Gln Glu Thr
                1925                1930                1935    
Ser Gln
        


<210> 6290
<211> 244
<212> PRT
<213> Homo sapiens

<400> 6290
Met Glu Gln Leu Lys Ser Phe Gln Ile Ile Ala His Leu Lys Arg Leu
 1               5                  10                  15      
Gln Glu Glu Ile Asn Glu Val Lys Thr Trp Ser Asn Arg Ile Thr Glu
            20                  25                  30          
Lys Gln Asp Ile Leu Asn Asn Ser Leu Thr Thr Leu Ser Gln Asp Ile
        35                  40                  45              
Thr Lys Val Asp Gln Ser Thr Thr Ser Met Ala Lys Asp Val Gly Leu
    50                  55                  60                  
Lys Ile Thr Ser Val Lys Thr Asp Ile Arg Arg Ile Ser Gly Leu Val
65                  70                  75                  80  
Thr Asp Val Ile Ser Leu Thr Asp Ser Val Gln Glu Leu Glu Asn Lys
                85                  90                  95      
Ile Glu Lys Val Glu Lys Asn Thr Val Lys Asn Ile Gly Asp Leu Leu
            100                 105                 110         
Ser Ser Ser Ile Asp Arg Thr Ala Thr Leu Arg Lys Thr Ala Ser Glu
        115                 120                 125             
Asn Ser Gln Arg Ile Asn Ser Val Lys Lys Thr Leu Thr Glu Leu Lys
    130                 135                 140                 
Ser Asp Phe Asp Lys His Thr Asp Arg Phe Leu Ser Leu Glu Ser Asp
145                 150                 155                 160 
Arg Ala Lys Val Leu Lys Thr Val Thr Phe Ala Asn Asp Leu Lys Pro
                165                 170                 175     
Lys Val Tyr Asn Leu Lys Lys Asp Phe Ser Arg Leu Glu Pro Leu Val
            180                 185                 190         
Asn Asp Leu Thr Leu Arg Ile Gly Arg Leu Val Thr Asp Leu Leu Gln
        195                 200                 205             
Arg Glu Lys Glu Ile Ala Phe Leu Ser Glu Lys Ile Ser Asn Leu Thr
    210                 215                 220                 
Ile Val Gln Ala Glu Ile Lys Asp Ile Lys Asp Glu Ile Ala His Ile
225                 230                 235                 240 
Ser Asp Met Asn
                


<210> 6291
<211> 691
<212> PRT
<213> Homo sapiens

<400> 6291
Met Glu Lys Ile Tyr Ser Arg Gly Glu Leu His His Phe Ile Asp Gly
 1               5                  10                  15      
Phe Asn Glu Glu Lys Ser Asn Trp Met Arg Tyr Val Asn Pro Ala His
            20                  25                  30          
Ser Pro Arg Glu Gln Asn Leu Ala Ala Cys Gln Asn Gly Met Asn Ile
        35                  40                  45              
Tyr Phe Tyr Thr Ile Lys Pro Ile Pro Ala Asn Gln Glu Leu Leu Val
    50                  55                  60                  
Trp Tyr Cys Arg Asp Phe Ala Glu Arg Leu His Tyr Pro Tyr Pro Gly
65                  70                  75                  80  
Glu Leu Thr Met Met Asn Leu Thr Gln Thr Gln Ser Ser Leu Lys Gln
                85                  90                  95      
Pro Ser Thr Glu Lys Asn Glu Leu Cys Pro Lys Asn Val Pro Lys Arg
            100                 105                 110         
Glu Tyr Ser Val Lys Glu Ile Leu Lys Leu Asp Ser Asn Pro Ser Lys
        115                 120                 125             
Gly Lys Asp Leu Tyr Arg Ser Asn Ile Ser Pro Leu Thr Ser Glu Lys
    130                 135                 140                 
Asp Leu Asp Asp Phe Arg Arg Arg Gly Ser Pro Glu Met Pro Phe Tyr
145                 150                 155                 160 
Pro Arg Val Val Tyr Pro Ile Arg Ala Pro Leu Pro Glu Asp Phe Leu
                165                 170                 175     
Lys Ala Ser Leu Ala Tyr Gly Ile Glu Arg Pro Thr Tyr Ile Thr Arg
            180                 185                 190         
Ser Pro Ile Pro Ser Ser Thr Thr Pro Ser Pro Ser Ala Arg Ser Ser
        195                 200                 205             
Pro Asp Gln Ser Leu Lys Ser Ser Ser Pro His Ser Ser Pro Gly Asn
    210                 215                 220                 
Thr Val Ser Pro Val Gly Pro Gly Ser Gln Glu His Arg Asp Ser Tyr
225                 230                 235                 240 
Ala Tyr Leu Asn Ala Ser Tyr Gly Thr Glu Gly Leu Gly Ser Tyr Pro
                245                 250                 255     
Gly Tyr Ala Pro Leu Pro His Leu Pro Pro Ala Phe Ile Pro Ser Tyr
            260                 265                 270         
Asn Ala His Tyr Pro Lys Phe Leu Leu Pro Pro Tyr Gly Met Asn Cys
        275                 280                 285             
Asn Gly Leu Ser Ala Val Ser Ser Met Asn Gly Ile Asn Asn Phe Gly
    290                 295                 300                 
Leu Phe Pro Arg Leu Cys Pro Val Tyr Ser Asn Leu Leu Gly Gly Gly
305                 310                 315                 320 
Ser Leu Pro His Pro Met Leu Asn Pro Thr Ser Leu Pro Ser Ser Leu
                325                 330                 335     
Pro Ser Asp Gly Ala Arg Arg Leu Leu Gln Pro Glu His Pro Arg Glu
            340                 345                 350         
Val Leu Val Pro Ala Pro His Ser Ala Phe Ser Phe Thr Gly Ala Ala
        355                 360                 365             
Ala Ser Met Lys Asp Lys Ala Cys Ser Pro Thr Ser Gly Ser Pro Thr
    370                 375                 380                 
Ala Gly Thr Ala Ala Thr Ala Glu His Val Val Gln Pro Lys Ala Thr
385                 390                 395                 400 
Ser Ala Ala Met Ala Ala Pro Ser Ser Asp Glu Ala Met Asn Leu Ile
                405                 410                 415     
Lys Asn Lys Arg Asn Met Thr Gly Tyr Lys Thr Leu Pro Tyr Pro Leu
            420                 425                 430         
Lys Lys Gln Asn Gly Lys Ile Lys Tyr Glu Cys Asn Val Cys Ala Lys
        435                 440                 445             
Thr Phe Gly Gln Leu Ser Asn Leu Lys Val His Leu Arg Val His Ser
    450                 455                 460                 
Gly Glu Arg Pro Phe Lys Cys Gln Thr Cys Asn Lys Gly Phe Thr Gln
465                 470                 475                 480 
Leu Ala His Leu Gln Lys His Tyr Leu Val His Thr Gly Glu Lys Pro
                485                 490                 495     
His Glu Cys Gln Val Cys His Lys Arg Phe Ser Ser Thr Ser Asn Leu
            500                 505                 510         
Lys Thr His Leu Arg Leu His Ser Gly Glu Lys Pro Tyr Gln Cys Lys
        515                 520                 525             
Val Cys Pro Ala Lys Phe Thr Gln Phe Val His Leu Lys Leu His Lys
    530                 535                 540                 
Arg Leu His Thr Arg Glu Arg Pro His Lys Cys Ser Gln Cys His Lys
545                 550                 555                 560 
Asn Tyr Ile His Leu Cys Ser Leu Lys Val His Leu Lys Gly Asn Cys
                565                 570                 575     
Ala Ala Ala Pro Ala Pro Gly Leu Pro Leu Glu Asp Leu Thr Arg Ile
            580                 585                 590         
Asn Glu Glu Ile Glu Lys Phe Asp Ile Ser Asp Asn Ala Asp Arg Leu
        595                 600                 605             
Glu Asp Val Glu Asp Asp Ile Ser Val Ile Ser Val Val Glu Lys Glu
    610                 615                 620                 
Ile Leu Ala Val Val Arg Lys Glu Lys Glu Glu Thr Gly Leu Lys Val
625                 630                 635                 640 
Ser Leu Gln Arg Asn Met Gly Asn Gly Leu Leu Ser Ser Gly Cys Ser
                645                 650                 655     
Leu Tyr Glu Ser Ser Asp Leu Pro Leu Met Lys Leu Pro Pro Ser Asn
            660                 665                 670         
Pro Leu Pro Leu Val Pro Val Lys Val Lys Gln Glu Thr Val Glu Pro
        675                 680                 685             
Met Asp Pro
    690     


<210> 6292
<211> 789
<212> PRT
<213> Homo sapiens

<400> 6292
Met Lys Met Asp Met Glu Asp Ala Asp Met Thr Leu Trp Thr Glu Ala
 1               5                  10                  15      
Glu Phe Glu Glu Lys Cys Thr Tyr Ile Val Asn Asp His Pro Trp Asp
            20                  25                  30          
Ser Gly Ala Asp Gly Gly Thr Ser Val Gln Ala Glu Ala Ser Leu Pro
        35                  40                  45              
Arg Asn Leu Leu Phe Lys Tyr Ala Thr Asn Ser Glu Glu Val Ile Gly
    50                  55                  60                  
Val Met Ser Lys Glu Tyr Ile Pro Lys Gly Thr Arg Phe Gly Pro Leu
65                  70                  75                  80  
Ile Gly Glu Ile Tyr Thr Asn Asp Thr Val Pro Lys Asn Ala Asn Arg
                85                  90                  95      
Lys Tyr Phe Trp Arg Ile Tyr Ser Arg Gly Glu Leu His His Phe Ile
            100                 105                 110         
Asp Gly Phe Asn Glu Glu Lys Ser Asn Trp Met Arg Tyr Val Asn Pro
        115                 120                 125             
Ala His Ser Pro Arg Glu Gln Asn Leu Ala Ala Cys Gln Asn Gly Met
    130                 135                 140                 
Asn Ile Tyr Phe Tyr Thr Ile Lys Pro Ile Pro Ala Asn Gln Glu Leu
145                 150                 155                 160 
Leu Val Trp Tyr Cys Arg Asp Phe Ala Glu Arg Leu His Tyr Pro Tyr
                165                 170                 175     
Pro Gly Glu Leu Thr Met Met Asn Leu Thr Gln Thr Gln Ser Ser Leu
            180                 185                 190         
Lys Gln Pro Ser Thr Glu Lys Asn Glu Leu Cys Pro Lys Asn Val Pro
        195                 200                 205             
Lys Arg Glu Tyr Ser Val Lys Glu Ile Leu Lys Leu Asp Ser Asn Pro
    210                 215                 220                 
Ser Lys Gly Lys Asp Leu Tyr Arg Ser Asn Ile Ser Pro Leu Thr Ser
225                 230                 235                 240 
Glu Lys Asp Leu Asp Asp Phe Arg Arg Arg Gly Ser Pro Glu Met Pro
                245                 250                 255     
Phe Tyr Pro Arg Val Val Tyr Pro Ile Arg Ala Pro Leu Pro Glu Asp
            260                 265                 270         
Phe Leu Lys Ala Ser Leu Ala Tyr Gly Ile Glu Arg Pro Thr Tyr Ile
        275                 280                 285             
Thr Arg Ser Pro Ile Pro Ser Ser Thr Thr Pro Ser Pro Ser Ala Arg
    290                 295                 300                 
Ser Ser Pro Asp Gln Ser Leu Lys Ser Ser Ser Pro His Ser Ser Pro
305                 310                 315                 320 
Gly Asn Thr Val Ser Pro Val Gly Pro Gly Ser Gln Glu His Arg Asp
                325                 330                 335     
Ser Tyr Ala Tyr Leu Asn Ala Ser Tyr Gly Thr Glu Gly Leu Gly Ser
            340                 345                 350         
Tyr Pro Gly Tyr Ala Pro Leu Pro His Leu Pro Pro Ala Phe Ile Pro
        355                 360                 365             
Ser Tyr Asn Ala His Tyr Pro Lys Phe Leu Leu Pro Pro Tyr Gly Met
    370                 375                 380                 
Asn Cys Asn Gly Leu Ser Ala Val Ser Ser Met Asn Gly Ile Asn Asn
385                 390                 395                 400 
Phe Gly Leu Phe Pro Arg Leu Cys Pro Val Tyr Ser Asn Leu Leu Gly
                405                 410                 415     
Gly Gly Ser Leu Pro His Pro Met Leu Asn Pro Thr Ser Leu Pro Ser
            420                 425                 430         
Ser Leu Pro Ser Asp Gly Ala Arg Arg Leu Leu Gln Pro Glu His Pro
        435                 440                 445             
Arg Glu Val Leu Val Pro Ala Pro His Ser Ala Phe Ser Phe Thr Gly
    450                 455                 460                 
Ala Ala Ala Ser Met Lys Asp Lys Ala Cys Ser Pro Thr Ser Gly Ser
465                 470                 475                 480 
Pro Thr Ala Gly Thr Ala Ala Thr Ala Glu His Val Val Gln Pro Lys
                485                 490                 495     
Ala Thr Ser Ala Ala Met Ala Ala Pro Ser Ser Asp Glu Ala Met Asn
            500                 505                 510         
Leu Ile Lys Asn Lys Arg Asn Met Thr Gly Tyr Lys Thr Leu Pro Tyr
        515                 520                 525             
Pro Leu Lys Lys Gln Asn Gly Lys Ile Lys Tyr Glu Cys Asn Val Cys
    530                 535                 540                 
Ala Lys Thr Phe Gly Gln Leu Ser Asn Leu Lys Val His Leu Arg Val
545                 550                 555                 560 
His Ser Gly Glu Arg Pro Phe Lys Cys Gln Thr Cys Asn Lys Gly Phe
                565                 570                 575     
Thr Gln Leu Ala His Leu Gln Lys His Tyr Leu Val His Thr Gly Glu
            580                 585                 590         
Lys Pro His Glu Cys Gln Val Cys His Lys Arg Phe Ser Ser Thr Ser
        595                 600                 605             
Asn Leu Lys Thr His Leu Arg Leu His Ser Gly Glu Lys Pro Tyr Gln
    610                 615                 620                 
Cys Lys Val Cys Pro Ala Lys Phe Thr Gln Phe Val His Leu Lys Leu
625                 630                 635                 640 
His Lys Arg Leu His Thr Arg Glu Arg Pro His Lys Cys Ser Gln Cys
                645                 650                 655     
His Lys Asn Tyr Ile His Leu Cys Ser Leu Lys Val His Leu Lys Gly
            660                 665                 670         
Asn Cys Ala Ala Ala Pro Ala Pro Gly Leu Pro Leu Glu Asp Leu Thr
        675                 680                 685             
Arg Ile Asn Glu Glu Ile Glu Lys Phe Asp Ile Ser Asp Asn Ala Asp
    690                 695                 700                 
Arg Leu Glu Asp Val Glu Asp Asp Ile Ser Val Ile Ser Val Val Glu
705                 710                 715                 720 
Lys Glu Ile Leu Ala Val Val Arg Lys Glu Lys Glu Glu Thr Gly Leu
                725                 730                 735     
Lys Val Ser Leu Gln Arg Asn Met Gly Asn Gly Leu Leu Ser Ser Gly
            740                 745                 750         
Cys Ser Leu Tyr Glu Ser Ser Asp Leu Pro Leu Met Lys Leu Pro Pro
        755                 760                 765             
Ser Asn Pro Leu Pro Leu Val Pro Val Lys Val Lys Gln Glu Thr Val
    770                 775                 780                 
Glu Pro Met Asp Pro
785                 


<210> 6293
<211> 741
<212> PRT
<213> Homo sapiens

<400> 6293
Met Gly Pro Pro Gly Pro Ala Leu Pro Ala Thr Met Asn Asn Ser Ser
 1               5                  10                  15      
Ser Glu Thr Arg Gly His Pro His Ser Ala Ser Ser Pro Ser Glu Arg
            20                  25                  30          
Val Phe Pro Met Pro Leu Pro Arg Lys Ala Pro Leu Asn Ile Pro Gly
        35                  40                  45              
Thr Pro Val Leu Glu Asp Phe Pro Gln Asn Asp Asp Glu Lys Glu Arg
    50                  55                  60                  
Leu Gln Arg Arg Arg Ser Arg Val Phe Asp Leu Gln Phe Ser Thr Asp
65                  70                  75                  80  
Ser Pro Arg Leu Leu Ala Ser Pro Ser Ser Arg Ser Ile Asp Ile Ser
                85                  90                  95      
Ala Thr Ile Pro Lys Phe Thr Asn Thr Gln Ile Thr Glu His Tyr Ser
            100                 105                 110         
Thr Cys Ile Lys Leu Ser Thr Glu Asn Lys Ile Thr Thr Lys Asn Ala
        115                 120                 125             
Phe Gly Leu His Leu Ile Asp Phe Met Ser Glu Ile Leu Lys Gln Lys
    130                 135                 140                 
Asp Thr Glu Pro Thr Asn Phe Lys Val Ala Ala Gly Thr Leu Asp Ala
145                 150                 155                 160 
Ser Thr Lys Ile Tyr Ala Val Arg Val Asp Ala Val His Ala Asp Val
                165                 170                 175     
Tyr Arg Val Leu Gly Gly Leu Gly Lys Asp Ala Pro Ser Leu Glu Glu
            180                 185                 190         
Val Glu Gly His Val Ala Asp Gly Ser Ala Thr Glu Met Gly Thr Thr
        195                 200                 205             
Lys Lys Ala Val Lys Pro Lys Lys Lys His Leu His Arg Thr Ile Glu
    210                 215                 220                 
Gln Asn Ile Asn Asn Leu Asn Val Ser Glu Ala Asp Arg Lys Cys Glu
225                 230                 235                 240 
Ile Asp Pro Met Phe Gln Lys Thr Ala Ala Ser Phe Asp Glu Cys Ser
                245                 250                 255     
Thr Ala Gly Val Phe Leu Ser Thr Leu His Cys Gln Asp Tyr Arg Ser
            260                 265                 270         
Glu Leu Leu Phe Pro Ser Asp Val Gln Thr Leu Ser Thr Gly Glu Pro
        275                 280                 285             
Leu Glu Leu Pro Glu Leu Gly Cys Val Glu Met Thr Asp Leu Lys Ala
    290                 295                 300                 
Pro Leu Gln Gln Cys Ala Glu Asp Arg Gln Ile Cys Pro Ser Leu Ala
305                 310                 315                 320 
Gly Phe Gln Phe Thr Gln Trp Asp Ser Glu Thr His Asn Glu Ser Val
                325                 330                 335     
Ser Ala Leu Val Asp Lys Phe Lys Lys Asn Asp Gln Val Phe Asp Ile
            340                 345                 350         
Asn Ala Glu Val Asp Glu Ser Asp Cys Gly Asp Phe Pro Asp Gly Ser
        355                 360                 365             
Leu Gly Asp Asp Phe Asp Ala Asn Asp Glu Pro Asp His Thr Ala Val
    370                 375                 380                 
Gly Asp His Glu Glu Phe Arg Ser Trp Lys Glu Pro Cys Gln Val Gln
385                 390                 395                 400 
Ser Cys Gln Glu Glu Met Ile Ser Leu Gly Asp Gly Asp Ile Arg Thr
                405                 410                 415     
Met Cys Pro Leu Leu Ser Met Lys Pro Gly Glu Tyr Ser Tyr Phe Ser
            420                 425                 430         
Pro Arg Thr Met Ser Met Trp Ala Gly Pro Asp His Trp Arg Phe Arg
        435                 440                 445             
Pro Arg Arg Lys Gln Asp Ala Pro Ser Gln Ser Glu Asn Lys Lys Lys
    450                 455                 460                 
Ser Thr Lys Lys Asp Phe Glu Ile Asp Phe Glu Asp Asp Ile Asp Phe
465                 470                 475                 480 
Asp Val Tyr Phe Arg Lys Thr Lys Ala Ala Thr Ile Leu Thr Lys Ser
                485                 490                 495     
Thr Leu Glu Asn Gln Asn Trp Arg Ala Thr Thr Leu Pro Thr Asp Phe
            500                 505                 510         
Asn Tyr Asn Val Asp Thr Leu Val Gln Leu His Leu Lys Pro Gly Thr
        515                 520                 525             
Arg Leu Leu Lys Met Ala Gln Gly His Arg Ala Glu Thr Glu His Tyr
    530                 535                 540                 
Glu Glu Ile Glu Asp Tyr Asp Tyr Asn Asn Pro Asn Asp Thr Ser Asn
545                 550                 555                 560 
Phe Cys Pro Gly Leu Gln Ala Ala Asp Ser Asp Asp Glu Asp Leu Asp
                565                 570                 575     
Asp Leu Phe Val Gly Pro Val Gly Asn Ser Asp Leu Ser Pro Tyr Pro
            580                 585                 590         
Cys His Pro Pro Lys Thr Ala Gln Gln Asn Gly Asp Thr Pro Glu Ala
        595                 600                 605             
Gln Gly Leu Asp Ile Thr Thr Tyr Gly Glu Ser Asn Leu Val Ala Glu
    610                 615                 620                 
Pro Gln Lys Val Asn Lys Ile Glu Ile His Tyr Ala Lys Thr Ala Lys
625                 630                 635                 640 
Lys Met Asp Met Lys Lys Leu Lys Gln Ser Met Trp Ser Leu Leu Thr
                645                 650                 655     
Ala Leu Ser Gly Lys Glu Ala Asp Ala Glu Ala Asn His Arg Glu Ala
            660                 665                 670         
Gly Lys Glu Ala Ala Leu Ala Glu Val Ala Asp Glu Lys Met Leu Ser
        675                 680                 685             
Gly Leu Thr Lys Asp Leu Gln Arg Ser Leu Pro Pro Val Met Ala Gln
    690                 695                 700                 
Asn Leu Ser Ile Pro Leu Ala Phe Ala Cys Leu Leu His Leu Ala Asn
705                 710                 715                 720 
Glu Lys Asn Leu Lys Leu Glu Gly Thr Glu Asp Leu Ser Asp Val Leu
                725                 730                 735     
Val Arg Gln Gly Asp
            740     


<210> 6294
<211> 709
<212> PRT
<213> Homo sapiens

<400> 6294
Met Glu Ser Pro Thr Lys Glu Ile Glu Glu Phe Glu Ser Asn Ser Leu
 1               5                  10                  15      
Lys Tyr Leu Gln Pro Glu Gln Ile Glu Lys Ile Trp Leu Arg Leu Arg
            20                  25                  30          
Gly Leu Arg Lys Tyr Lys Lys Thr Ser Gln Arg Leu Arg Ser Leu Val
        35                  40                  45              
Lys Gln Leu Glu Arg Gly Glu Ala Ser Val Val Asp Leu Lys Lys Asn
    50                  55                  60                  
Leu Glu Tyr Ala Ala Thr Val Leu Glu Ser Val Tyr Ile Asp Glu Thr
65                  70                  75                  80  
Arg Arg Leu Leu Asp Thr Glu Asp Glu Leu Ser Asp Ile Gln Ser Asp
                85                  90                  95      
Ala Val Pro Ser Glu Val Arg Asp Trp Leu Ala Ser Thr Phe Thr Arg
            100                 105                 110         
Gln Met Gly Met Met Leu Arg Arg Ser Asp Glu Lys Pro Arg Phe Lys
        115                 120                 125             
Ser Ile Val His Ala Val Gln Ala Gly Ile Phe Val Glu Arg Met Tyr
    130                 135                 140                 
Arg Arg Thr Ser Asn Met Val Gly Leu Ser Tyr Pro Pro Ala Val Ile
145                 150                 155                 160 
Glu Ala Leu Lys Asp Val Asp Lys Trp Ser Phe Asp Val Phe Ser Leu
                165                 170                 175     
Asn Glu Ala Ser Gly Asp His Ala Leu Lys Phe Ile Phe Tyr Glu Leu
            180                 185                 190         
Leu Thr Arg Tyr Asp Leu Ile Ser Arg Phe Lys Ile Pro Ile Ser Ala
        195                 200                 205             
Leu Val Ser Phe Val Glu Ala Leu Glu Val Gly Tyr Ser Lys His Lys
    210                 215                 220                 
Asn Pro Tyr His Asn Leu Met His Ala Ala Asp Val Thr Gln Thr Val
225                 230                 235                 240 
His Tyr Leu Leu Tyr Lys Thr Gly Val Ala Asn Trp Leu Thr Glu Leu
                245                 250                 255     
Glu Ile Phe Ala Ile Ile Phe Ser Ala Ala Ile His Asp Tyr Glu His
            260                 265                 270         
Thr Gly Thr Thr Asn Asn Phe His Ile Gln Thr Arg Ser Asp Pro Ala
        275                 280                 285             
Ile Leu Tyr Asn Asp Arg Ser Val Leu Glu Asn His His Leu Ser Ala
    290                 295                 300                 
Ala Tyr Arg Leu Leu Gln Asp Asp Glu Glu Met Asn Ile Leu Ile Asn
305                 310                 315                 320 
Leu Ser Lys Asp Asp Trp Arg Glu Phe Arg Thr Leu Val Ile Glu Met
                325                 330                 335     
Val Met Ala Thr Asp Met Ser Cys His Phe Gln Gln Ile Lys Ala Met
            340                 345                 350         
Lys Thr Ala Leu Gln Gln Pro Glu Ala Ile Glu Lys Pro Lys Ala Leu
        355                 360                 365             
Ser Leu Met Leu His Thr Ala Asp Ile Ser His Pro Ala Lys Ala Trp
    370                 375                 380                 
Asp Leu His His Arg Trp Thr Met Ser Leu Leu Glu Glu Phe Phe Arg
385                 390                 395                 400 
Gln Gly Asp Arg Glu Ala Glu Leu Gly Leu Pro Phe Ser Pro Leu Cys
                405                 410                 415     
Asp Arg Lys Ser Thr Met Val Ala Gln Ser Gln Val Gly Phe Ile Asp
            420                 425                 430         
Phe Ile Val Glu Pro Thr Phe Thr Val Leu Thr Asp Met Thr Glu Lys
        435                 440                 445             
Ile Val Ser Pro Leu Ile Asp Glu Thr Ser Gln Thr Gly Gly Thr Gly
    450                 455                 460                 
Gln Arg Arg Ser Ser Leu Asn Ser Ile Ser Ser Ser Asp Ala Lys Arg
465                 470                 475                 480 
Ser Gly Val Lys Thr Ser Gly Ser Glu Gly Ser Ala Pro Ile Asn Asn
                485                 490                 495     
Ser Val Ile Ser Val Asp Tyr Lys Ser Phe Lys Ala Thr Trp Thr Glu
            500                 505                 510         
Val Val His Ile Asn Arg Glu Arg Trp Arg Ala Lys Val Pro Lys Glu
        515                 520                 525             
Glu Lys Ala Lys Lys Glu Ala Glu Glu Lys Ala Arg Leu Ala Ala Glu
    530                 535                 540                 
Glu Gln Gln Lys Glu Met Glu Ala Lys Ser Gln Ala Glu Glu Gly Ala
545                 550                 555                 560 
Ser Gly Lys Ala Glu Lys Lys Thr Ser Gly Glu Thr Lys Asn Gln Val
                565                 570                 575     
Asn Gly Thr Arg Ala Asn Lys Ser Asp Asn Pro Arg Gly Lys Asn Ser
            580                 585                 590         
Lys Ala Glu Lys Ser Ser Gly Glu Gln Gln Gln Asn Gly Asp Phe Lys
        595                 600                 605             
Asp Gly Lys Asn Lys Thr Asp Lys Lys Asp His Ser Asn Ile Gly Asn
    610                 615                 620                 
Asp Ser Lys Lys Thr Asp Gly Thr Lys Gln Arg Ser His Gly Ser Pro
625                 630                 635                 640 
Ala Pro Ser Thr Ser Ser Thr Cys Arg Leu Thr Leu Pro Val Ile Lys
                645                 650                 655     
Pro Pro Leu Arg His Phe Lys Arg Pro Ala Tyr Ala Ser Ser Ser Tyr
            660                 665                 670         
Ala Pro Ser Val Ser Lys Lys Thr Asp Glu His Pro Ala Arg Tyr Lys
        675                 680                 685             
Met Leu Asp Gln Arg Ile Lys Met Lys Lys Ile Gln Asn Ile Ser His
    690                 695                 700                 
Asn Trp Asn Arg Lys
705                 


<210> 6295
<211> 760
<212> PRT
<213> Homo sapiens

<400> 6295
Met Lys Leu Asn Val Asp Gly Leu Leu Val Tyr Phe Pro Tyr Asp Tyr
 1               5                  10                  15      
Ile Tyr Pro Glu Gln Phe Ser Tyr Met Arg Glu Leu Lys Arg Thr Leu
            20                  25                  30          
Asp Ala Lys Gly His Gly Val Leu Glu Met Pro Ser Gly Thr Gly Lys
        35                  40                  45              
Thr Val Ser Leu Leu Ala Leu Ile Met Ala Tyr Gln Arg Ala Tyr Pro
    50                  55                  60                  
Leu Glu Val Thr Lys Leu Ile Tyr Cys Ser Arg Thr Val Pro Glu Ile
65                  70                  75                  80  
Glu Lys Val Ile Glu Glu Leu Arg Lys Leu Leu Asn Phe Tyr Glu Lys
                85                  90                  95      
Gln Glu Gly Glu Lys Leu Pro Phe Leu Gly Leu Ala Leu Ser Ser Arg
            100                 105                 110         
Lys Asn Leu Cys Ile His Pro Glu Val Thr Pro Leu Arg Phe Gly Lys
        115                 120                 125             
Asp Val Asp Gly Lys Cys His Ser Leu Thr Ala Ser Tyr Val Arg Ala
    130                 135                 140                 
Gln Tyr Gln His Asp Thr Ser Leu Pro His Cys Arg Phe Tyr Glu Glu
145                 150                 155                 160 
Phe Asp Ala His Gly Arg Glu Val Pro Leu Pro Ala Gly Ile Tyr Asn
                165                 170                 175     
Leu Asp Asp Leu Lys Ala Leu Gly Arg Arg Gln Gly Trp Cys Pro Tyr
            180                 185                 190         
Phe Leu Ala Arg Tyr Ser Ile Leu His Ala Asn Val Val Val Tyr Ser
        195                 200                 205             
Tyr His Tyr Leu Leu Asp Pro Lys Ile Ala Asp Leu Val Ser Lys Glu
    210                 215                 220                 
Leu Ala Arg Lys Ala Val Val Val Phe Asp Glu Ala His Asn Ile Asp
225                 230                 235                 240 
Asn Val Cys Ile Asp Ser Met Ser Val Asn Leu Thr Arg Arg Thr Leu
                245                 250                 255     
Asp Arg Cys Gln Gly Asn Leu Glu Thr Leu Gln Lys Thr Val Leu Arg
            260                 265                 270         
Ile Lys Glu Thr Asp Glu Gln Arg Leu Arg Asp Glu Tyr Arg Arg Leu
        275                 280                 285             
Val Glu Gly Leu Arg Glu Ala Ser Ala Ala Arg Glu Thr Asp Ala His
    290                 295                 300                 
Leu Ala Asn Pro Val Leu Pro Asp Glu Val Leu Gln Glu Ala Val Pro
305                 310                 315                 320 
Gly Ser Ile Arg Thr Ala Glu His Phe Leu Gly Phe Leu Arg Arg Leu
                325                 330                 335     
Leu Glu Tyr Val Lys Trp Arg Leu Arg Val Gln His Val Val Gln Glu
            340                 345                 350         
Ser Pro Pro Ala Phe Leu Ser Gly Leu Ala Gln Arg Val Cys Ile Gln
        355                 360                 365             
Arg Lys Pro Leu Arg Phe Cys Ala Glu Arg Leu Arg Ser Leu Leu His
    370                 375                 380                 
Thr Leu Glu Ile Thr Asp Leu Ala Asp Phe Ser Pro Leu Thr Leu Leu
385                 390                 395                 400 
Ala Asn Phe Ala Thr Leu Val Ser Thr Tyr Ala Lys Gly Phe Thr Ile
                405                 410                 415     
Ile Ile Glu Pro Phe Asp Asp Arg Thr Pro Thr Ile Ala Asn Pro Ile
            420                 425                 430         
Leu His Phe Ser Cys Met Asp Ala Ser Leu Ala Ile Lys Pro Val Phe
        435                 440                 445             
Glu Arg Phe Gln Ser Val Ile Ile Thr Ser Gly Thr Leu Ser Pro Leu
    450                 455                 460                 
Asp Ile Tyr Pro Lys Ile Leu Asp Phe His Pro Val Thr Met Ala Thr
465                 470                 475                 480 
Phe Thr Met Thr Leu Ala Arg Val Cys Leu Cys Pro Met Ile Ile Gly
                485                 490                 495     
Arg Gly Asn Asp Gln Val Ala Ile Ser Ser Lys Phe Glu Thr Arg Glu
            500                 505                 510         
Asp Ile Ala Val Ile Arg Asn Tyr Gly Asn Leu Leu Leu Glu Met Ser
        515                 520                 525             
Ala Val Val Pro Asp Gly Ile Val Ala Phe Phe Thr Ser Tyr Gln Tyr
    530                 535                 540                 
Met Glu Ser Thr Val Ala Ser Trp Tyr Glu Gln Gly Ile Leu Glu Asn
545                 550                 555                 560 
Ile Gln Arg Asn Lys Leu Leu Phe Ile Glu Thr Gln Asp Gly Ala Glu
                565                 570                 575     
Thr Ser Val Ala Leu Glu Lys Tyr Gln Glu Ala Cys Glu Asn Gly Arg
            580                 585                 590         
Gly Ala Ile Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu Gly Ile
        595                 600                 605             
Asp Phe Val His His Tyr Gly Arg Ala Val Ile Met Phe Gly Val Pro
    610                 615                 620                 
Tyr Val Tyr Thr Gln Ser Arg Ile Leu Lys Ala Arg Leu Glu Tyr Leu
625                 630                 635                 640 
Arg Asp Gln Phe Gln Ile Arg Glu Asn Asp Phe Leu Thr Phe Asp Ala
                645                 650                 655     
Met Arg His Ala Ala Gln Cys Val Gly Arg Ala Ile Arg Gly Lys Thr
            660                 665                 670         
Asp Tyr Gly Leu Met Val Phe Ala Asp Lys Arg Phe Ala Arg Gly Asp
        675                 680                 685             
Lys Arg Gly Lys Leu Pro Arg Trp Ile Gln Glu His Leu Thr Asp Ala
    690                 695                 700                 
Asn Leu Asn Leu Thr Val Asp Glu Gly Val Gln Val Ala Lys Tyr Phe
705                 710                 715                 720 
Leu Arg Gln Met Ala Gln Pro Phe His Arg Glu Asp Gln Leu Gly Leu
                725                 730                 735     
Ser Leu Leu Ser Leu Glu Gln Leu Glu Ser Glu Glu Thr Leu Lys Arg
            740                 745                 750         
Ile Glu Gln Ile Ala Gln Gln Leu
        755                 760 


<210> 6296
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 6296
Ala Arg Val Ala Ala Asn Ala Pro Pro Pro Ala Ser His Pro Arg Arg
 1               5                  10                  15      
Pro Pro Arg Pro Gly Thr Asn Gly Trp Ser Arg Arg Gly Ser Cys Arg
            20                  25                  30          
Ala Ser Trp Ser Arg Asp Cys Ser Gly Val Arg Ser Arg Arg Val Ala
        35                  40                  45              
Leu Gly Met Ala Met Asp Gln Val Asn Ala Leu Cys Glu Gln Leu Val
    50                  55                  60                  
Lys Ala Val Thr Val Met Met Asp Pro Asn Ser Thr Gln Arg Tyr Arg
65                  70                  75                  80  
Leu Glu Ala Leu Lys Phe Cys Glu Glu Phe Lys Glu Lys Cys Pro Ile
                85                  90                  95      
Cys Val Pro Cys Gly Leu Arg Leu Ala Glu Lys Thr Gln Val Ala Ile
            100                 105                 110         
Val Arg His Phe Gly Leu Gln Ile Leu Glu His Val Val Lys Phe Arg
        115                 120                 125             
Trp Asn Gly Met Ser Arg Leu Glu Lys Val Tyr Leu Lys Asn Ser Val
    130                 135                 140                 
Met Glu Leu Ile Ala Asn Gly Thr Leu Asn Ile Leu Glu Glu Glu Asn
145                 150                 155                 160 
His Ile Lys Asp Ala Leu Ser Arg Ile Val Val Glu Met Ile Lys Arg
                165                 170                 175     
Glu Trp Pro Gln His Trp Pro Asp Met Leu Ile Glu Leu Asp Thr Leu
            180                 185                 190         
Ser Lys Gln Gly Glu Thr Gln Thr Glu Leu Val Met Phe Ile Leu Leu
        195                 200                 205             
Arg Leu Ala Glu Asp Val Val Thr Phe Gln Thr Leu Pro Pro Gln Arg
    210                 215                 220                 
Arg Arg Asp Ile Gln Gln Thr Leu Thr Gln Asn Met Glu Arg Ile Phe
225                 230                 235                 240 
Ser Phe Leu Leu Asn Thr Leu Gln Glu Asn Val Asn Lys Tyr Gln Gln
                245                 250                 255     
Val Lys Thr Asp Thr Ser Gln Glu Ser Lys Ala Gln Ala Asn Cys Arg
            260                 265                 270         
Val Gly Val Ala Ala Leu Asn Thr Leu Ala Gly Tyr Ile Asp Trp Val
        275                 280                 285             
Ser Met Ser His Ile Thr Ala Glu Asn Cys Lys Leu Leu Glu Ile Leu
    290                 295                 300                 
Cys Leu Leu Leu Asn Glu Gln Glu Leu Gln Leu Gly Ala Ala Glu Cys
305                 310                 315                 320 
Leu Leu Ile Ala Val Ser Arg Lys Gly Lys Leu Glu Asp Arg Lys Pro
                325                 330                 335     
Leu Met Val Leu Phe Gly Asp Val Ala Met His Tyr Ile Leu Ser Ala
            340                 345                 350         
Ala Gln Thr Ala Asp Gly Gly Gly Leu Val Glu Lys His Tyr Val Phe
        355                 360                 365             
Leu Lys Arg Leu Cys Gln Val Leu Cys Ala Leu Gly Asn Gln Leu Cys
    370                 375                 380                 
Ala Leu Leu Gly Ala Asp Ser Asp Val Glu Thr Pro Ser Asn Phe Gly
385                 390                 395                 400 
Lys Tyr Leu Glu Ser Phe Leu Ala Phe Thr Thr His Pro Ser Gln Phe
                405                 410                 415     
Leu Arg Ser Ser Thr Gln Met Thr Trp Gly Ala Leu Phe Arg His Glu
            420                 425                 430         
Ile Leu Ser Arg Asp Pro Leu Leu Leu Ala Ile Ile Pro Lys Tyr Leu
        435                 440                 445             
Arg Ala Ser Met Thr Asn Leu Val Lys Met Gly Phe Pro Ser Lys Thr
    450                 455                 460                 
Asp Ser Pro Ser Cys Glu Tyr Ser Arg Phe Asp Phe Asp Ser Asp Glu
465                 470                 475                 480 
Asp Phe Asn Ala Phe Phe Asn Ser Ser Arg Ala Gln Gln Gly Glu Val
                485                 490                 495     
Met Arg Leu Ala Cys Arg Leu Asp Pro Lys Thr Ser Phe Gln Met Ala
            500                 505                 510         
Gly Glu Trp Leu Lys Tyr Gln Leu Ser Thr Phe Leu Asp Ala Gly Ser
        515                 520                 525             
Val Asn Ser Cys Ser Ala Val Gly Thr Gly Glu Gly Ser Leu Cys Ser
    530                 535                 540                 
Val Phe Ser Pro Ser Phe Val Gln Trp Glu Ala Met Thr Leu Phe Leu
545                 550                 555                 560 
Glu Ser Val Ile Thr Gln Met Phe Arg Thr Leu Asn Arg Glu Glu Ile
                565                 570                 575     
Pro Val Asn Asp Gly Ile Glu Leu Leu Gln Met Val Leu Asn Phe Asp
            580                 585                 590         
Thr Lys Asp Pro Leu Ile Leu Ser Cys Val Leu Thr Asn Val Ser Ala
        595                 600                 605             
Leu Phe Pro Phe Val Thr Tyr Arg Pro Glu Phe Leu Pro Gln Val Phe
    610                 615                 620                 
Ser Lys Leu Phe Ser Ser Val Thr Phe Glu Thr Val Glu Glu Ser Lys
625                 630                 635                 640 
Ala Pro Arg Thr Arg Ala Val Arg Asn Val Arg Arg His Ala Cys Ser
                645                 650                 655     
Ser Ile Ile Lys Met Cys Arg Asp Tyr Pro Gln Leu Val Leu Pro Asn
            660                 665                 670         
Phe Asp Met Leu Tyr Asn His Val Lys Gln Leu Leu Ser Asn Glu Leu
        675                 680                 685             
Leu Leu Thr Gln Met Glu Lys Cys Ala Leu Met Glu Ala Leu Val Leu
    690                 695                 700                 
Ile Ser Asn Gln Phe Lys Asn Tyr Glu Arg Gln Lys Val Phe Leu Glu
705                 710                 715                 720 
Glu Leu Met Ala Pro Val Ala Ser Ile Trp Leu Ser Gln Asp Met His
                725                 730                 735     
Arg Val Leu Ser Asp Val Asp Ala Phe Ile Ala Tyr Val Gly Thr Asp
            740                 745                 750         
Gln Lys Ser Cys Asp Pro Gly Leu Glu Asp Pro Cys Gly Leu Asn Arg
        755                 760                 765             
Ala Arg Met Ser Phe Cys Val Tyr Ser Ile Leu Gly Val Val Lys Arg
    770                 775                 780                 
Thr Cys Trp Pro Thr Asp Leu Glu Glu Ala Lys Ala Gly Gly Phe Val
785                 790                 795                 800 
Val Gly Tyr Thr Ser Ser Gly Asn Pro Ile Phe Arg Asn Pro Cys Thr
                805                 810                 815     
Glu Gln Ile Leu Lys Leu Leu Asp Asn Leu Leu Ala Leu Ile Arg Thr
            820                 825                 830         
His Asn Thr Leu Tyr Ala Pro Glu Met Leu Ala Lys Met Ala Glu Pro
        835                 840                 845             
Phe Thr Lys Ala Leu Asp Met Leu Asp Ala Glu Lys Ser Ala Ile Leu
    850                 855                 860                 
Gly Leu Pro Gln Pro Leu Leu Glu Leu Asn Asp Ser Pro Val Phe Lys
865                 870                 875                 880 
Thr Val Leu Glu Arg Met Gln Arg Phe Phe Ser Thr Leu Tyr Glu Asn
                885                 890                 895     
Cys Phe His Ile Leu Gly Lys Ala Gly Pro Ser Met Gln Gln Asp Phe
            900                 905                 910         
Tyr Thr Val Glu Asp Leu Ala Thr Gln Leu Leu Ser Ser Ala Phe Val
        915                 920                 925             
Asn Leu Asn Asn Ile Pro Asp Tyr Arg Leu Arg Pro Met Leu Pro Arg
    930                 935                 940                 
Val Phe Val Lys Pro Leu Val Leu Phe Cys Pro Pro Glu His Tyr Glu
945                 950                 955                 960 
Ala Leu Val Ser Pro Ile Leu Gly Pro Leu Phe Thr Tyr Leu His Met
                965                 970                 975     
Arg Leu Ser Gln Lys Trp Gln Val Ile Asn Gln Arg Ser Leu Leu Cys
            980                 985                 990         
Gly Glu Asp Glu Ala Ala Asp Glu Asn Pro Glu Ser Gln Glu Met Leu
        995                 1000                1005            
Glu Glu Gln Leu Val Arg Met Leu Thr Arg Glu Val Met Asp Leu Ile
    1010                1015                1020                
Thr Val Cys Cys Val Ser Lys Lys Gly Ala Asp His Ser Ser Ala Pro
1025                1030                1035                1040
Pro Ala Asp Gly Asp Asp Glu Glu Met Met Ala Thr Glu Val Thr Pro
                1045                1050                1055    
Ser Ala Met Ala Glu Leu Thr Asp Leu Gly Lys Cys Leu Met Lys His
            1060                1065                1070        
Glu Asp Val Cys Thr Ala Leu Leu Ile Thr Ala Phe Asn Ser Leu Ala
        1075                1080                1085            
Trp Lys Asp Thr Leu Ser Cys Gln Arg Thr Thr Ser Gln Leu Cys Trp
    1090                1095                1100                
Pro Leu Leu Lys Gln Val Leu Ser Gly Thr Leu Leu Ala Asp Ala Val
1105                1110                1115                1120
Thr Trp Leu Phe Thr Ser Val Leu Lys Gly Leu Gln Met His Gly Gln
                1125                1130                1135    
His Asp Gly Cys Met Ala Ser Leu Val His Leu Ala Phe Gln Ile Tyr
            1140                1145                1150        
Glu Ala Leu Arg Pro Arg Tyr Leu Glu Ile Arg Ala Val Met Glu Gln
        1155                1160                1165            
Ile Pro Glu Ile Gln Lys Asp Ser Leu Asp Gln Phe Asp Cys Lys Leu
    1170                1175                1180                
Leu Asn Pro Ser Leu Gln Lys Val Ala Asp Lys Arg Arg Lys Asp Gln
1185                1190                1195                1200
Phe Lys Arg Leu Ile Ala Gly Cys Ile Gly Lys Pro Leu Gly Glu Gln
                1205                1210                1215    
Phe Arg Lys Glu Val His Ile Lys Asn Leu Pro Ser Leu Phe Lys Lys
            1220                1225                1230        
Thr Lys Pro Met Leu Glu Thr Glu Val Leu Asp Asn Asp Gly Gly Gly
        1235                1240                1245            
Leu Ala Thr Ile Phe Glu Pro
    1250                1255


<210> 6297
<211> 913
<212> PRT
<213> Homo sapiens

<400> 6297
Met Gln Ala Glu Ala Ala Asp Trp Phe Ser Ser Met Val Arg Gly Gly
 1               5                  10                  15      
Arg Pro Gly Arg Pro Arg Arg Gly Cys Arg Ala Gly Glu Asn Arg Gly
            20                  25                  30          
Phe Pro Gly Pro Pro Ala Pro Gln Pro Ala Arg Pro Pro Ser Pro Pro
        35                  40                  45              
Pro Ala Ala Leu Ser Leu Cys Pro Pro Gln Pro Phe Gln Lys His Val
    50                  55                  60                  
Tyr Tyr Pro Leu Ala Ser Gly Pro Glu Gly Pro Asp Val Ala Val Ala
65                  70                  75                  80  
Ala Ala Ala Ala Gly Ala Ala Ser Met Ala Cys Ala Pro Pro Ser Ala
                85                  90                  95      
Ala Ser Gly Pro Leu Pro Phe Phe Gln Phe Arg Pro Arg Leu Glu Ser
            100                 105                 110         
Val Asp Trp Arg Arg Leu Ser Ala Ile Asp Val Asp Lys Val Ala Gly
        115                 120                 125             
Ala Val Asp Val Leu Thr Leu Gln Glu Asn Ile Met Asn Ile Thr Phe
    130                 135                 140                 
Cys Lys Leu Glu Asp Glu Lys Cys Pro His Cys Gln Ser Gly Val Asp
145                 150                 155                 160 
Pro Val Leu Leu Lys Leu Ile Arg Leu Ala Gln Phe Thr Ile Glu Tyr
                165                 170                 175     
Leu Leu His Ser Gln Glu Phe Leu Thr Ser Gln Leu His Thr Leu Glu
            180                 185                 190         
Glu Arg Leu Arg Leu Ser His Cys Asp Gly Glu Gln Ser Lys Lys Leu
        195                 200                 205             
Leu Thr Lys Gln Ala Gly Glu Ile Lys Thr Leu Lys Glu Glu Cys Lys
    210                 215                 220                 
Arg Arg Lys Lys Met Ile Ser Thr Gln Gln Leu Met Ile Glu Ala Lys
225                 230                 235                 240 
Ala Asn Tyr Tyr Gln Cys His Phe Cys Asp Lys Ala Phe Met Asn Gln
                245                 250                 255     
Ala Phe Leu Gln Ser His Ile Gln Arg Arg His Thr Glu Glu Asn Ser
            260                 265                 270         
His Phe Glu Tyr Gln Lys Asn Ala Gln Ile Glu Lys Leu Arg Ser Glu
        275                 280                 285             
Ile Val Val Leu Lys Glu Glu Leu Gln Leu Thr Arg Ser Glu Leu Glu
    290                 295                 300                 
Ala Ala His His Ala Ser Ala Val Arg Phe Ser Lys Glu Tyr Glu Met
305                 310                 315                 320 
Gln Lys Thr Lys Glu Glu Asp Phe Leu Lys Leu Phe Asp Arg Trp Lys
                325                 330                 335     
Glu Glu Glu Lys Glu Lys Leu Val Asp Glu Met Glu Lys Val Lys Glu
            340                 345                 350         
Met Phe Met Lys Glu Phe Lys Glu Leu Thr Ser Lys Asn Ser Ala Leu
        355                 360                 365             
Glu Tyr Gln Leu Ser Glu Ile Gln Lys Ser Asn Met Gln Ile Lys Ser
    370                 375                 380                 
Asn Ile Gly Thr Leu Lys Asp Ala His Glu Phe Lys Glu Asp Arg Ser
385                 390                 395                 400 
Pro Tyr Pro Gln Asp Phe His Asn Val Met Gln Leu Leu Asp Ser Gln
                405                 410                 415     
Glu Ser Lys Trp Thr Ala Arg Val Gln Ala Ile His Gln Glu His Lys
            420                 425                 430         
Lys Glu Lys Gly Arg Leu Leu Ser His Ile Glu Lys Leu Arg Thr Ser
        435                 440                 445             
Met Ile Asp Asp Leu Asn Ala Ser Asn Val Phe Tyr Lys Lys Arg Ile
    450                 455                 460                 
Glu Glu Leu Gly Gln Arg Leu Gln Glu Gln Asn Glu Leu Ile Ile Thr
465                 470                 475                 480 
Gln Arg Gln Gln Ile Lys Asp Phe Thr Cys Asn Pro Leu Asn Ser Ile
                485                 490                 495     
Ser Glu Pro Lys Gly Asn Pro Leu Ala Trp Gln Ala Phe Glu Ser Gln
            500                 505                 510         
Pro Ala Ala Pro Ala Val Pro Met Asn Ala Pro Ala Leu His Thr Leu
        515                 520                 525             
Glu Thr Lys Ser Ser Leu Pro Met Val His Glu Gln Ala Phe Ser Ser
    530                 535                 540                 
His Ile Leu Glu Pro Ile Glu Glu Leu Ser Glu Glu Glu Lys Gly Arg
545                 550                 555                 560 
Glu Asn Glu Gln Lys Leu Asn Asn Asn Lys Met His Leu Arg Lys Ala
                565                 570                 575     
Leu Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met Val Glu
            580                 585                 590         
Gln Asn Leu Met Glu Lys Leu Glu Thr Leu Gly Ile Asn Ala Asp Ile
        595                 600                 605             
Arg Gly Ile Ser Ser Asp Gln Leu His Arg Val Leu Lys Ser Val Glu
    610                 615                 620                 
Ser Glu Arg His Lys Gln Glu Arg Glu Ile Pro Asn Phe His Gln Ile
625                 630                 635                 640 
Arg Glu Phe Leu Glu His Gln Val Ser Cys Lys Ile Glu Glu Lys Ala
                645                 650                 655     
Leu Leu Ser Ser Asp Gln Cys Ser Val Ser Gln Met Asp Thr Leu Ser
            660                 665                 670         
Thr Gly Glu Val Pro Lys Met Ile Gln Leu Pro Ser Lys Asn Arg Gln
        675                 680                 685             
Leu Ile Arg Gln Lys Ala Val Ser Thr Asp Arg Thr Ser Val Pro Lys
    690                 695                 700                 
Ile Lys Lys Asn Val Met Glu Asp Pro Phe Pro Arg Lys Ser Ser Thr
705                 710                 715                 720 
Ile Thr Thr Pro Pro Phe Ser Ser Glu Glu Glu Gln Glu Asp Asp Asp
                725                 730                 735     
Leu Ile Arg Ala Tyr Ala Ser Pro Gly Pro Leu Pro Val Pro Pro Pro
            740                 745                 750         
Gln Asn Lys Gly Ser Phe Gly Lys Asn Thr Val Lys Ser Asp Ala Asp
        755                 760                 765             
Gly Thr Glu Gly Ser Glu Ile Glu Asp Thr Asp Asp Ser Pro Lys Pro
    770                 775                 780                 
Ala Gly Val Ala Val Lys Thr Pro Thr Glu Lys Val Glu Lys Met Phe
785                 790                 795                 800 
Pro His Arg Lys Asn Val Asn Lys Pro Val Gly Gly Thr Asn Val Pro
                805                 810                 815     
Glu Met Phe Ile Lys Lys Glu Glu Leu Gln Glu Leu Lys Cys Ala Asp
            820                 825                 830         
Val Glu Asp Glu Asp Trp Asp Ile Ser Ser Leu Glu Glu Glu Ile Ser
        835                 840                 845             
Leu Gly Lys Lys Ser Gly Lys Glu Gln Lys Glu Pro Pro Pro Ala Lys
    850                 855                 860                 
Asn Glu Pro His Phe Ala His Val Leu Asn Ala Trp Gly Ala Phe Asn
865                 870                 875                 880 
Pro Lys Gly Pro Lys Gly Glu Gly Leu Gln Glu Asn Glu Ser Ser Thr
                885                 890                 895     
Leu Lys Ser Ser Leu Val Thr Val Thr Asp Trp Ser Asp Thr Ser Asp
            900                 905                 910         
Val
    


<210> 6298
<211> 848
<212> PRT
<213> Homo sapiens

<400> 6298
Met Gln Ala Glu Ala Ala Asp Trp Phe Ser Ser Met Pro Phe Gln Lys
 1               5                  10                  15      
His Val Tyr Tyr Pro Leu Ala Ser Gly Pro Glu Gly Pro Asp Val Ala
            20                  25                  30          
Val Ala Ala Ala Ala Ala Gly Ala Ala Ser Met Ala Cys Ala Pro Pro
        35                  40                  45              
Ser Ala Ala Ser Gly Pro Leu Pro Phe Phe Gln Phe Arg Pro Arg Leu
    50                  55                  60                  
Glu Ser Val Asp Trp Arg Arg Leu Ser Ala Ile Asp Val Asp Lys Val
65                  70                  75                  80  
Ala Gly Ala Val Asp Val Leu Thr Leu Gln Glu Asn Ile Met Asn Ile
                85                  90                  95      
Thr Phe Cys Lys Leu Glu Asp Glu Lys Cys Pro His Cys Gln Ser Gly
            100                 105                 110         
Val Asp Pro Val Leu Leu Lys Leu Ile Arg Leu Ala Gln Phe Thr Ile
        115                 120                 125             
Glu Tyr Leu Leu His Ser Gln Glu Phe Leu Thr Ser Gln Leu His Thr
    130                 135                 140                 
Leu Glu Glu Arg Leu Arg Leu Ser His Cys Asp Gly Glu Gln Ser Lys
145                 150                 155                 160 
Lys Leu Leu Thr Lys Gln Ala Gly Glu Ile Lys Thr Leu Lys Glu Glu
                165                 170                 175     
Cys Lys Arg Arg Lys Lys Met Ile Ser Thr Gln Gln Leu Met Ile Glu
            180                 185                 190         
Ala Lys Ala Asn Tyr Tyr Gln Cys His Phe Cys Asp Lys Ala Phe Met
        195                 200                 205             
Asn Gln Ala Phe Leu Gln Ser His Ile Gln Arg Arg His Thr Glu Glu
    210                 215                 220                 
Asn Ser His Phe Glu Tyr Gln Lys Asn Ala Gln Ile Glu Lys Leu Arg
225                 230                 235                 240 
Ser Glu Ile Val Val Leu Lys Glu Glu Leu Gln Leu Thr Arg Ser Glu
                245                 250                 255     
Leu Glu Ala Ala His His Ala Ser Ala Val Arg Phe Ser Lys Glu Tyr
            260                 265                 270         
Glu Met Gln Lys Thr Lys Glu Glu Asp Phe Leu Lys Leu Phe Asp Arg
        275                 280                 285             
Trp Lys Glu Glu Glu Lys Glu Lys Leu Val Asp Glu Met Glu Lys Val
    290                 295                 300                 
Lys Glu Met Phe Met Lys Glu Phe Lys Glu Leu Thr Ser Lys Asn Ser
305                 310                 315                 320 
Ala Leu Glu Tyr Gln Leu Ser Glu Ile Gln Lys Ser Asn Met Gln Ile
                325                 330                 335     
Lys Ser Asn Ile Gly Thr Leu Lys Asp Ala His Glu Phe Lys Glu Asp
            340                 345                 350         
Arg Ser Pro Tyr Pro Gln Asp Phe His Asn Val Met Gln Leu Leu Asp
        355                 360                 365             
Ser Gln Glu Ser Lys Trp Thr Ala Arg Val Gln Ala Ile His Gln Glu
    370                 375                 380                 
His Lys Lys Glu Lys Gly Arg Leu Leu Ser His Ile Glu Lys Leu Arg
385                 390                 395                 400 
Thr Ser Met Ile Asp Asp Leu Asn Ala Ser Asn Val Phe Tyr Lys Lys
                405                 410                 415     
Arg Ile Glu Glu Leu Gly Gln Arg Leu Gln Glu Gln Asn Glu Leu Ile
            420                 425                 430         
Ile Thr Gln Arg Gln Gln Ile Lys Asp Phe Thr Cys Asn Pro Leu Asn
        435                 440                 445             
Ser Ile Ser Glu Pro Lys Val Asn Ala Pro Ala Leu His Thr Leu Glu
    450                 455                 460                 
Thr Lys Ser Ser Leu Pro Met Val His Glu Gln Ala Phe Ser Ser His
465                 470                 475                 480 
Ile Leu Glu Pro Ile Glu Glu Leu Ser Glu Glu Glu Lys Gly Arg Glu
                485                 490                 495     
Asn Glu Gln Lys Leu Asn Asn Asn Lys Met His Leu Arg Lys Ala Leu
            500                 505                 510         
Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met Val Glu Gln
        515                 520                 525             
Asn Leu Met Glu Lys Leu Glu Thr Leu Gly Ile Asn Ala Asp Ile Arg
    530                 535                 540                 
Gly Ile Ser Ser Asp Gln Leu His Arg Val Leu Lys Ser Val Glu Ser
545                 550                 555                 560 
Glu Arg His Lys Gln Glu Arg Glu Ile Pro Asn Phe His Gln Ile Arg
                565                 570                 575     
Glu Phe Leu Glu His Gln Val Ser Cys Lys Ile Glu Glu Lys Ala Leu
            580                 585                 590         
Leu Ser Ser Asp Gln Cys Ser Val Ser Gln Met Asp Thr Leu Ser Thr
        595                 600                 605             
Gly Glu Val Pro Lys Met Ile Gln Leu Pro Ser Lys Asn Arg Gln Leu
    610                 615                 620                 
Ile Arg Gln Lys Ala Val Ser Thr Asp Arg Thr Ser Val Pro Lys Ile
625                 630                 635                 640 
Lys Lys Asn Val Met Glu Asp Pro Phe Pro Arg Lys Ser Ser Thr Ile
                645                 650                 655     
Thr Thr Pro Pro Phe Ser Ser Glu Glu Glu Gln Glu Asp Asp Asp Leu
            660                 665                 670         
Ile Arg Ala Tyr Ala Ser Pro Gly Pro Leu Pro Val Pro Pro Pro Gln
        675                 680                 685             
Asn Lys Gly Ser Phe Gly Lys Asn Thr Val Lys Ser Asp Ala Asp Gly
    690                 695                 700                 
Thr Glu Gly Ser Glu Ile Glu Asp Thr Asp Asp Ser Pro Lys Pro Ala
705                 710                 715                 720 
Gly Val Ala Val Lys Thr Pro Thr Glu Lys Val Glu Lys Met Phe Pro
                725                 730                 735     
His Arg Lys Asn Val Asn Lys Pro Val Gly Gly Thr Asn Val Pro Glu
            740                 745                 750         
Met Phe Ile Lys Lys Glu Glu Leu Gln Glu Leu Lys Cys Ala Asp Val
        755                 760                 765             
Glu Asp Glu Asp Trp Asp Ile Ser Ser Leu Glu Glu Glu Ile Ser Leu
    770                 775                 780                 
Gly Lys Lys Ser Gly Lys Glu Gln Lys Glu Pro Pro Pro Ala Lys Asn
785                 790                 795                 800 
Glu Pro His Phe Ala His Val Leu Asn Ala Trp Gly Ala Phe Asn Pro
                805                 810                 815     
Lys Gly Pro Lys Gly Glu Gly Leu Gln Glu Asn Glu Ser Ser Thr Leu
            820                 825                 830         
Lys Ser Ser Leu Val Thr Val Thr Asp Trp Ser Asp Thr Ser Asp Val
        835                 840                 845             


<210> 6299
<211> 3526
<212> PRT
<213> Homo sapiens

<400> 6299
Met Asn Met Val Lys Arg Ile Met Gly Arg Pro Arg Gln Glu Glu Cys
 1               5                  10                  15      
Ser Pro Gln Asp Asn Ala Leu Gly Leu Met His Leu Arg Arg Leu Phe
            20                  25                  30          
Thr Glu Leu Cys His Pro Pro Arg His Met Thr Gln Lys Glu Gln Glu
        35                  40                  45              
Glu Lys Leu Tyr Met Met Leu Pro Val Phe Asn Arg Val Phe Gly Asn
    50                  55                  60                  
Ala Pro Pro Asn Thr Met Thr Glu Lys Phe Ser Asp Leu Leu Gln Phe
65                  70                  75                  80  
Thr Thr Gln Val Ser Arg Leu Met Val Thr Glu Ile Arg Arg Arg Ala
                85                  90                  95      
Ser Asn Lys Ser Thr Glu Ala Ala Ser Arg Ala Ile Val Gln Phe Leu
            100                 105                 110         
Glu Ile Asn Gln Ser Glu Glu Ala Ser Arg Gly Trp Met Leu Leu Thr
        115                 120                 125             
Thr Ile Asn Leu Leu Ala Ser Ser Gly Gln Lys Thr Val Asp Cys Met
    130                 135                 140                 
Thr Thr Met Ser Val Pro Ser Thr Leu Val Lys Cys Leu Tyr Leu Phe
145                 150                 155                 160 
Phe Asp Leu Pro His Val Pro Glu Ala Val Gly Gly Ala Gln Asn Glu
                165                 170                 175     
Leu Pro Leu Ala Glu Arg Arg Gly Leu Leu Gln Lys Val Phe Val Gln
            180                 185                 190         
Ile Leu Val Lys Leu Cys Ser Phe Val Ser Pro Ala Glu Glu Leu Ala
        195                 200                 205             
Gln Lys Asp Asp Leu Gln Leu Leu Phe Ser Ala Ile Thr Ser Trp Cys
    210                 215                 220                 
Pro Pro Tyr Asn Leu Pro Trp Arg Lys Ser Ala Gly Glu Val Leu Met
225                 230                 235                 240 
Thr Ile Ser Arg His Gly Leu Ser Val Asn Val Val Lys Tyr Ile His
                245                 250                 255     
Glu Lys Glu Cys Leu Ser Thr Cys Val Gln Asn Met Gln Gln Ser Asp
            260                 265                 270         
Asp Leu Ser Pro Leu Glu Ile Val Glu Met Phe Ala Gly Leu Ser Cys
        275                 280                 285             
Phe Leu Lys Asp Ser Ser Asp Val Ser Gln Thr Leu Leu Asp Asp Phe
    290                 295                 300                 
Arg Ile Trp Gln Gly Tyr Asn Phe Leu Cys Asp Leu Leu Leu Arg Leu
305                 310                 315                 320 
Glu Gln Ala Lys Glu Ala Glu Ser Lys Asp Ala Leu Lys Asp Leu Val
                325                 330                 335     
Asn Leu Ile Thr Ser Leu Thr Thr Tyr Gly Val Ser Glu Leu Lys Pro
            340                 345                 350         
Ala Gly Ile Thr Thr Gly Ala Pro Phe Leu Leu Pro Gly Phe Ala Val
        355                 360                 365             
Pro Gln Pro Ala Gly Lys Gly His Ser Val Arg Asn Val Gln Ala Phe
    370                 375                 380                 
Ala Val Leu Gln Asn Ala Phe Leu Lys Ala Lys Thr Ser Phe Leu Ala
385                 390                 395                 400 
Gln Ile Ile Leu Asp Ala Ile Thr Asn Ile Tyr Met Ala Asp Asn Ala
                405                 410                 415     
Asn Tyr Phe Ile Leu Glu Ser Gln His Thr Leu Ser Gln Phe Ala Glu
            420                 425                 430         
Lys Ile Ser Lys Leu Pro Glu Val Gln Asn Lys Tyr Phe Glu Met Leu
        435                 440                 445             
Glu Phe Val Val Phe Ser Leu Asn Tyr Ile Pro Cys Lys Glu Leu Ile
    450                 455                 460                 
Ser Val Ser Ile Leu Leu Lys Ser Ser Ser Ser Tyr His Cys Ser Ile
465                 470                 475                 480 
Ile Ala Met Lys Thr Leu Leu Lys Phe Thr Arg His Asp Tyr Ile Phe
                485                 490                 495     
Lys Asp Val Phe Arg Glu Val Gly Leu Leu Glu Val Met Val Asn Leu
            500                 505                 510         
Leu His Lys Tyr Ala Ala Leu Leu Lys Asp Pro Thr Gln Ala Leu Asn
        515                 520                 525             
Glu Gln Gly Asp Ser Arg Asn Asn Ser Ser Val Glu Asp Gln Lys His
    530                 535                 540                 
Leu Ala Leu Leu Val Met Glu Thr Leu Thr Val Leu Leu Gln Gly Ser
545                 550                 555                 560 
Asn Thr Asn Ala Gly Ile Phe Arg Glu Phe Gly Gly Ala Arg Cys Ala
                565                 570                 575     
His Asn Ile Val Lys Tyr Pro Gln Cys Arg Gln His Ala Leu Met Thr
            580                 585                 590         
Ile Gln Gln Leu Val Leu Ser Pro Asn Gly Asp Asp Asp Met Gly Thr
        595                 600                 605             
Leu Leu Gly Leu Met His Ser Ala Pro Pro Thr Glu Leu Gln Leu Lys
    610                 615                 620                 
Thr Asp Ile Leu Arg Ala Leu Leu Ser Val Leu Arg Glu Ser His Arg
625                 630                 635                 640 
Ser Arg Thr Val Phe Arg Lys Val Gly Gly Phe Val Tyr Ile Thr Ser
                645                 650                 655     
Leu Leu Val Ala Met Glu Arg Ser Leu Ser Cys Pro Pro Lys Asn Gly
            660                 665                 670         
Trp Glu Lys Val Asn Gln Asn Gln Val Phe Glu Leu Leu His Thr Val
        675                 680                 685             
Phe Cys Thr Leu Thr Ala Ala Met Arg Tyr Glu Pro Ala Asn Ser His
    690                 695                 700                 
Phe Phe Lys Thr Glu Ile Gln Tyr Glu Lys Leu Ala Asp Ala Val Arg
705                 710                 715                 720 
Phe Leu Gly Cys Phe Ser Asp Leu Arg Lys Ile Ser Ala Met Asn Val
                725                 730                 735     
Phe Pro Ser Asn Thr Gln Pro Phe Gln Arg Leu Leu Glu Glu Asp Val
            740                 745                 750         
Ile Ser Ile Glu Ser Val Ser Pro Thr Leu Arg His Cys Ser Lys Leu
        755                 760                 765             
Phe Ile Tyr Leu Tyr Lys Val Ala Thr Asp Ser Phe Asp Ser Arg Ala
    770                 775                 780                 
Glu Gln Ile Pro Pro Cys Leu Thr Ser Glu Ser Ser Leu Pro Ser Pro
785                 790                 795                 800 
Trp Gly Thr Pro Ala Leu Ser Arg Lys Arg His Ala Tyr His Ser Val
                805                 810                 815     
Ser Thr Pro Pro Val Tyr Pro Pro Lys Asn Val Ala Asp Leu Lys Leu
            820                 825                 830         
His Val Thr Thr Ser Ser Leu Gln Ser Ser Asp Ala Val Ile Ile His
        835                 840                 845             
Pro Gly Ala Met Leu Ala Met Leu Asp Leu Leu Ala Ser Val Gly Ser
    850                 855                 860                 
Val Thr Gln Pro Glu His Ala Leu Asp Leu Gln Leu Ala Val Ala Asn
865                 870                 875                 880 
Ile Leu Gln Ser Leu Val His Thr Glu Arg Asn Gln Gln Val Met Cys
                885                 890                 895     
Glu Ala Gly Leu His Ala Arg Leu Leu Gln Arg Cys Ser Ala Ala Leu
            900                 905                 910         
Ala Asp Glu Asp His Ser Leu His Pro Pro Leu Gln Arg Met Phe Glu
        915                 920                 925             
Arg Leu Ala Ser Gln Ala Leu Glu Pro Met Val Leu Arg Glu Phe Leu
    930                 935                 940                 
Arg Leu Ala Ser Pro Leu Asn Cys Gly Ala Trp Asp Lys Lys Leu Leu
945                 950                 955                 960 
Lys Gln Tyr Arg Val His Lys Pro Ser Ser Leu Ser Tyr Glu Pro Glu
                965                 970                 975     
Met Arg Ser Ser Met Ile Thr Ser Leu Glu Gly Leu Gly Thr Asp Asn
            980                 985                 990         
Val Phe Ser Leu His Glu Asp Asn His Tyr Arg Ile Ser Lys Ser Leu
        995                 1000                1005            
Val Lys Ser Ala Glu Gly Ser Thr Val Pro Leu Thr Arg Val Lys Cys
    1010                1015                1020                
Leu Val Ser Met Thr Thr Pro His Asp Ile Arg Leu His Gly Ser Ser
1025                1030                1035                1040
Val Thr Pro Ala Phe Val Glu Phe Asp Thr Ser Leu Glu Gly Phe Gly
                1045                1050                1055    
Cys Leu Phe Leu Pro Ser Leu Ala Pro His Asn Ala Pro Thr Asn Asn
            1060                1065                1070        
Thr Val Thr Thr Gly Leu Ile Asp Gly Ala Val Val Ser Gly Ile Gly
        1075                1080                1085            
Ser Gly Glu Arg Phe Phe Pro Pro Pro Ser Gly Leu Ser Tyr Ser Ser
    1090                1095                1100                
Trp Phe Cys Ile Glu His Phe Ser Ser Pro Pro Asn Asn His Pro Val
1105                1110                1115                1120
Arg Leu Leu Thr Val Val Arg Arg Ala Asn Ser Ser Glu Gln His Tyr
                1125                1130                1135    
Val Cys Leu Ala Ile Val Leu Ser Ala Lys Asp Arg Ser Leu Ile Val
            1140                1145                1150        
Ser Thr Lys Glu Glu Leu Leu Gln Asn Tyr Val Asp Asp Phe Ser Glu
        1155                1160                1165            
Glu Ser Ser Phe Tyr Glu Ile Leu Pro Cys Cys Ala Arg Phe Arg Cys
    1170                1175                1180                
Gly Glu Leu Ile Ile Glu Gly Gln Trp His His Leu Val Leu Val Met
1185                1190                1195                1200
Ser Lys Gly Met Leu Lys Asn Ser Thr Ala Ala Leu Tyr Ile Asp Gly
                1205                1210                1215    
Gln Leu Val Asn Thr Val Lys Leu His Tyr Val His Ser Thr Pro Gly
            1220                1225                1230        
Gly Ser Gly Ser Ala Asn Pro Pro Val Val Ser Thr Val Tyr Ala Tyr
        1235                1240                1245            
Ile Gly Thr Pro Pro Ala Gln Arg Gln Ile Ala Ser Leu Val Trp Arg
    1250                1255                1260                
Leu Gly Pro Thr His Phe Leu Glu Glu Val Leu Pro Ser Ser Asn Val
1265                1270                1275                1280
Thr Thr Ile Tyr Glu Leu Gly Pro Asn Tyr Val Gly Ser Phe Gln Ala
                1285                1290                1295    
Val Cys Met Pro Cys Lys Asp Ala Lys Ser Glu Gly Val Val Pro Ser
            1300                1305                1310        
Pro Val Ser Leu Val Pro Glu Glu Lys Val Ser Phe Gly Leu Tyr Ala
        1315                1320                1325            
Leu Ser Val Ser Ser Leu Thr Val Ala Arg Ile Arg Lys Val Tyr Asn
    1330                1335                1340                
Lys Leu Asp Ser Lys Ala Ile Ala Lys Gln Leu Gly Ile Ser Ser His
1345                1350                1355                1360
Glu Asn Ala Thr Pro Val Lys Leu Ile His Asn Ser Ala Gly His Leu
                1365                1370                1375    
Asn Gly Ser Ala Arg Thr Ile Gly Ala Ala Leu Ile Gly Tyr Leu Gly
            1380                1385                1390        
Val Arg Thr Phe Val Pro Lys Pro Val Ala Thr Thr Leu Gln Tyr Val
        1395                1400                1405            
Gly Gly Ala Ala Ala Ile Leu Gly Leu Val Ala Met Ala Ser Asp Val
    1410                1415                1420                
Glu Gly Leu Tyr Ala Ala Val Lys Ala Leu Val Cys Val Val Lys Ser
1425                1430                1435                1440
Asn Pro Leu Ala Ser Lys Glu Met Glu Arg Ile Lys Gly Tyr Gln Leu
                1445                1450                1455    
Leu Ala Met Leu Leu Lys Lys Lys Arg Ser Leu Leu Asn Ser His Ile
            1460                1465                1470        
Leu His Leu Thr Phe Ser Leu Val Gly Thr Val Asp Ser Gly His Glu
        1475                1480                1485            
Thr Ser Ile Ile Pro Asn Ser Thr Ala Phe Gln Asp Leu Leu Cys Asp
    1490                1495                1500                
Phe Glu Val Trp Leu His Ala Pro Tyr Glu Leu His Leu Ser Leu Phe
1505                1510                1515                1520
Glu His Phe Ile Glu Leu Leu Thr Glu Ser Ser Glu Ala Ser Lys Asn
                1525                1530                1535    
Ala Lys Leu Met Arg Glu Phe Gln Leu Ile Pro Lys Leu Leu Leu Thr
            1540                1545                1550        
Leu Arg Asp Met Ser Leu Ser Gln Pro Thr Ile Ala Ala Ile Ser Asn
        1555                1560                1565            
Val Leu Ser Phe Leu Leu Gln Gly Phe Pro Ser Ser Asn Asp Leu Leu
    1570                1575                1580                
Arg Phe Gly Gln Phe Ile Ser Ser Thr Leu Pro Thr Phe Ala Val Cys
1585                1590                1595                1600
Glu Lys Phe Val Val Met Glu Ile Asn Asn Glu Glu Lys Leu Asp Thr
                1605                1610                1615    
Gly Thr Glu Glu Glu Phe Gly Gly Leu Val Ser Ala Asn Leu Ile Leu
            1620                1625                1630        
Leu Arg Asn Arg Leu Leu Asp Ile Leu Leu Lys Leu Ile Tyr Thr Ser
        1635                1640                1645            
Lys Glu Lys Thr Ser Ile Asn Leu Gln Ala Cys Glu Glu Leu Val Lys
    1650                1655                1660                
Thr Leu Gly Phe Asp Trp Ile Met Met Phe Met Glu Glu His Leu His
1665                1670                1675                1680
Ser Thr Thr Val Thr Ala Ala Met Arg Ile Leu Val Val Leu Leu Ser
                1685                1690                1695    
Asn Gln Ser Ile Leu Ile Lys Phe Lys Glu Gly Leu Ser Gly Gly Gly
            1700                1705                1710        
Trp Leu Glu Gln Thr Asp Ser Val Leu Thr Asn Lys Ile Gly Thr Val
        1715                1720                1725            
Leu Gly Phe Asn Val Gly Arg Ser Ala Gly Gly Arg Ser Thr Val Arg
    1730                1735                1740                
Glu Ile Asn Arg Asp Ala Cys His Phe Pro Gly Phe Pro Val Leu Gln
1745                1750                1755                1760
Ser Phe Leu Pro Lys His Thr Asn Val Pro Ala Leu Tyr Phe Leu Leu
                1765                1770                1775    
Met Ala Leu Phe Leu Gln Gln Pro Val Ser Glu Leu Pro Glu Asn Leu
            1780                1785                1790        
Gln Val Ser Val Pro Val Ile Ser Cys Arg Ser Lys Gln Gly Cys Gln
        1795                1800                1805            
Phe Asp Leu Asp Ser Ile Trp Thr Phe Ile Phe Gly Val Pro Ala Ser
    1810                1815                1820                
Ser Gly Thr Val Val Ser Ser Ile His Asn Val Cys Thr Glu Ala Val
1825                1830                1835                1840
Phe Leu Leu Leu Gly Met Leu Arg Ser Met Leu Thr Ser Pro Trp Gln
                1845                1850                1855    
Ser Glu Glu Glu Gly Ser Trp Leu Arg Glu Tyr Pro Val Thr Leu Met
            1860                1865                1870        
Gln Phe Phe Arg Tyr Leu Tyr His Asn Val Pro Asp Leu Ala Ser Met
        1875                1880                1885            
Trp Met Ser Pro Asp Phe Leu Cys Ala Leu Ala Ala Thr Val Phe Pro
    1890                1895                1900                
Phe Asn Ile Arg Pro Tyr Ser Glu Met Val Thr Asp Leu Asp Asp Glu
1905                1910                1915                1920
Val Gly Ser Pro Ala Glu Glu Phe Lys Ala Phe Ala Ala Asp Thr Gly
                1925                1930                1935    
Met Asn Arg Ser Gln Ser Glu Tyr Cys Asn Val Gly Thr Lys Thr Tyr
            1940                1945                1950        
Leu Thr Asn His Pro Ala Lys Lys Phe Val Phe Asp Phe Met Arg Val
        1955                1960                1965            
Leu Ile Ile Asp Asn Leu Cys Leu Thr Pro Ala Ser Lys Gln Thr Pro
    1970                1975                1980                
Leu Ile Asp Leu Leu Leu Glu Ala Ser Pro Glu Arg Ser Thr Arg Thr
1985                1990                1995                2000
Gln Gln Lys Glu Phe Gln Thr Tyr Ile Leu Asp Ser Val Met Asp His
                2005                2010                2015    
Leu Leu Ala Ala Asp Val Leu Leu Gly Glu Asp Ala Ser Leu Pro Ile
            2020                2025                2030        
Thr Ser Gly Gly Ser Tyr Gln Val Leu Val Asn Asn Val Phe Tyr Phe
        2035                2040                2045            
Thr Gln Arg Val Val Asp Lys Leu Trp Gln Gly Met Phe Asn Lys Glu
    2050                2055                2060                
Ser Lys Leu Leu Ile Asp Phe Ile Ile Gln Leu Ile Ala Gln Ser Lys
2065                2070                2075                2080
Arg Arg Ser Gln Gly Leu Ser Leu Asp Ala Val Tyr His Cys Leu Asn
                2085                2090                2095    
Arg Thr Ile Leu Tyr Gln Phe Ser Arg Ala His Lys Thr Val Pro Gln
            2100                2105                2110        
Gln Val Ala Leu Leu Asp Ser Leu Arg Val Leu Thr Val Asn Arg Asn
        2115                2120                2125            
Leu Ile Leu Gly Pro Gly Asn His Asp Gln Glu Phe Ile Ser Cys Leu
    2130                2135                2140                
Ala His Cys Leu Ile Asn Leu His Val Gly Ser Asn Val Asp Gly Phe
2145                2150                2155                2160
Gly Leu Glu Ala Glu Ala Arg Met Thr Thr Trp His Ile Met Ile Pro
                2165                2170                2175    
Ser Asp Ile Glu Pro Asp Gly Ser Tyr Ser Gln Asp Ile Ser Glu Gly
            2180                2185                2190        
Arg Gln Leu Leu Ile Lys Ala Val Asn Arg Val Trp Thr Glu Leu Ile
        2195                2200                2205            
His Ser Lys Lys Gln Val Leu Glu Glu Leu Phe Lys Val Thr Leu Pro
    2210                2215                2220                
Val Asn Glu Arg Gly His Val Asp Ile Ala Thr Ala Arg Pro Leu Ile
2225                2230                2235                2240
Glu Glu Ala Ala Leu Lys Cys Trp Gln Asn His Leu Ala His Glu Lys
                2245                2250                2255    
Lys Cys Ile Ser Arg Gly Glu Ala Leu Ala Pro Thr Thr Gln Ser Lys
            2260                2265                2270        
Leu Ser Arg Val Ser Ser Gly Phe Gly Leu Ser Lys Leu Thr Gly Ser
        2275                2280                2285            
Arg Arg Asn Arg Lys Glu Ser Gly Leu Asn Lys His Ser Leu Ser Thr
    2290                2295                2300                
Gln Glu Ile Ser Gln Trp Met Phe Thr His Ile Ala Val Val Arg Asp
2305                2310                2315                2320
Leu Val Asp Thr Gln Tyr Lys Glu Tyr Gln Glu Arg Gln Gln Asn Ala
                2325                2330                2335    
Leu Lys Tyr Val Thr Glu Glu Trp Cys Gln Ile Glu Cys Glu Leu Leu
            2340                2345                2350        
Arg Glu Arg Gly Leu Trp Gly Pro Pro Ile Gly Ser His Leu Asp Lys
        2355                2360                2365            
Trp Met Leu Glu Met Thr Glu Gly Pro Cys Arg Met Arg Lys Lys Met
    2370                2375                2380                
Val Arg Asn Asp Met Phe Tyr Asn His Tyr Pro Tyr Val Pro Glu Thr
2385                2390                2395                2400
Glu Gln Glu Thr Asn Val Ala Ser Glu Ile Pro Ser Lys Gln Pro Glu
                2405                2410                2415    
Thr Pro Asp Asp Ile Pro Gln Lys Lys Pro Ala Arg Tyr Arg Arg Ala
            2420                2425                2430        
Val Ser Tyr Asp Ser Lys Glu Tyr Tyr Met Arg Leu Ala Ser Gly Asn
        2435                2440                2445            
Pro Ala Ile Val Gln Asp Ala Ile Val Glu Ser Ser Glu Gly Glu Ala
    2450                2455                2460                
Ala Gln Gln Glu Pro Glu His Gly Glu Asp Thr Ile Ala Lys Val Lys
2465                2470                2475                2480
Gly Leu Val Lys Pro Pro Leu Lys Arg Ser Arg Ser Ala Pro Asp Gly
                2485                2490                2495    
Gly Asp Glu Glu Asn Gln Glu Gln Leu Gln Asp Gln Ile Ala Glu Gly
            2500                2505                2510        
Ser Ser Ile Glu Glu Glu Glu Lys Thr Asp Asn Ala Thr Leu Leu Arg
        2515                2520                2525            
Leu Leu Glu Glu Gly Glu Lys Ile Gln His Met Tyr Arg Cys Ala Arg
    2530                2535                2540                
Val Gln Gly Leu Asp Thr Ser Glu Gly Leu Leu Leu Phe Gly Lys Glu
2545                2550                2555                2560
His Phe Tyr Val Ile Asp Gly Phe Thr Met Thr Ala Thr Arg Glu Ile
                2565                2570                2575    
Arg Asp Ile Glu Thr Leu Pro Pro Asn Met His Glu Pro Ile Ile Pro
            2580                2585                2590        
Arg Gly Ala Arg Gln Gly Pro Ser Gln Leu Lys Arg Thr Cys Ser Ile
        2595                2600                2605            
Phe Ala Tyr Glu Asp Ile Lys Glu Val His Lys Arg Arg Tyr Leu Leu
    2610                2615                2620                
Gln Pro Ile Ala Val Glu Val Phe Ser Gly Asp Gly Arg Asn Tyr Leu
2625                2630                2635                2640
Leu Ala Phe Gln Lys Gly Ile Arg Asn Lys Val Tyr Gln Arg Phe Leu
                2645                2650                2655    
Ala Val Val Pro Ser Leu Thr Asp Ser Ser Glu Ser Val Ser Gly Gln
            2660                2665                2670        
Arg Pro Asn Thr Ser Val Glu Gln Gly Ser Gly Leu Leu Ser Thr Leu
        2675                2680                2685            
Val Gly Glu Lys Ser Val Thr Gln Arg Trp Glu Arg Gly Glu Ile Ser
    2690                2695                2700                
Asn Phe Gln Tyr Leu Met His Leu Asn Thr Leu Ala Gly Arg Ser Tyr
2705                2710                2715                2720
Asn Asp Leu Met Gln Tyr Pro Val Phe Pro Trp Ile Leu Ala Asp Tyr
                2725                2730                2735    
Asp Ser Glu Glu Val Asp Leu Thr Asn Pro Lys Thr Phe Arg Asn Leu
            2740                2745                2750        
Ala Lys Pro Met Gly Ala Gln Thr Asp Glu Arg Leu Ala Gln Tyr Lys
        2755                2760                2765            
Lys Arg Tyr Lys Asp Trp Glu Asp Pro Asn Gly Glu Thr Pro Ala Tyr
    2770                2775                2780                
His Tyr Gly Thr His Tyr Ser Ser Ala Met Ile Val Ala Ser Tyr Leu
2785                2790                2795                2800
Val Arg Met Glu Pro Phe Thr Gln Ile Phe Leu Arg Leu Gln Gly Gly
                2805                2810                2815    
His Phe Asp Leu Ala Asp Arg Met Phe His Ser Val Arg Glu Ala Trp
            2820                2825                2830        
Tyr Ser Ala Ser Lys His Asn Met Ala Asp Val Lys Glu Leu Ile Pro
        2835                2840                2845            
Glu Phe Phe Tyr Leu Pro Glu Phe Leu Phe Asn Ser Asn Asn Phe Asp
    2850                2855                2860                
Leu Gly Cys Lys Gln Asn Gly Thr Lys Leu Gly Asp Val Ile Leu Pro
2865                2870                2875                2880
Pro Trp Ala Lys Gly Asp Pro Arg Glu Phe Ile Arg Val His Arg Glu
                2885                2890                2895    
Ala Leu Glu Cys Asp Tyr Val Ser Ala His Leu His Glu Trp Ile Asp
            2900                2905                2910        
Leu Ile Phe Gly Tyr Lys Gln Gln Gly Pro Ala Ala Val Glu Ala Val
        2915                2920                2925            
Asn Val Phe His His Leu Phe Tyr Glu Gly Gln Val Asp Ile Tyr Thr
    2930                2935                2940                
Ile Asn Asp Pro Leu Lys Glu Thr Ala Thr Ile Gly Phe Ile Asn Asn
2945                2950                2955                2960
Phe Gly Gln Ile Pro Lys Gln Leu Phe Lys Lys Pro His Pro Pro Lys
                2965                2970                2975    
Arg Val Arg Ser Arg Leu Asn Gly Asp Asn Ala Gly Ile Ser Val Leu
            2980                2985                2990        
Pro Gly Ser Thr Ser Asp Lys Ile Phe Phe His His Leu Asp Asn Leu
        2995                3000                3005            
Arg Pro Ser Leu Thr Pro Val Lys Glu Leu Lys Glu Pro Val Gly Gln
    3010                3015                3020                
Ile Val Cys Thr Asp Lys Gly Ile Leu Ala Val Glu Gln Asn Lys Val
3025                3030                3035                3040
Leu Ile Pro Pro Thr Trp Asn Lys Thr Phe Ala Trp Gly Tyr Ala Asp
                3045                3050                3055    
Leu Ser Cys Arg Leu Gly Thr Tyr Glu Ser Asp Lys Ala Met Thr Val
            3060                3065                3070        
Tyr Glu Cys Leu Ser Glu Trp Gly Gln Ile Leu Cys Ala Ile Cys Pro
        3075                3080                3085            
Asn Pro Lys Leu Val Ile Thr Gly Gly Thr Ser Thr Val Val Cys Val
    3090                3095                3100                
Trp Glu Met Gly Thr Ser Lys Glu Lys Ala Lys Thr Val Thr Leu Lys
3105                3110                3115                3120
Gln Ala Leu Leu Gly His Thr Asp Thr Val Thr Cys Ala Thr Ala Ser
                3125                3130                3135    
Leu Ala Tyr His Ile Ile Val Ser Gly Ser Arg Asp Arg Thr Cys Ile
            3140                3145                3150        
Ile Trp Asp Leu Asn Lys Leu Ser Phe Leu Thr Gln Leu Arg Gly His
        3155                3160                3165            
Arg Ala Pro Val Ser Ala Leu Cys Ile Asn Glu Leu Thr Gly Asp Ile
    3170                3175                3180                
Val Ser Cys Ala Gly Thr Tyr Ile His Val Trp Ser Ile Asn Gly Asn
3185                3190                3195                3200
Pro Ile Val Ser Val Asn Thr Phe Thr Gly Arg Ser Gln Gln Ile Ile
                3205                3210                3215    
Cys Cys Cys Met Ser Glu Met Asn Glu Trp Asp Thr Gln Asn Val Ile
            3220                3225                3230        
Val Thr Gly His Ser Asp Gly Val Val Arg Phe Trp Arg Met Glu Phe
        3235                3240                3245            
Leu Gln Val Pro Glu Thr Pro Ala Pro Glu Pro Ala Glu Val Leu Glu
    3250                3255                3260                
Met Gln Glu Asp Cys Pro Glu Ala Gln Ile Gly Gln Glu Ala Gln Asp
3265                3270                3275                3280
Glu Asp Ser Ser Asp Ser Glu Ala Asp Glu Gln Ser Ile Ser Gln Asp
                3285                3290                3295    
Pro Lys Asp Thr Pro Ser Gln Pro Ser Ser Thr Ser His Arg Pro Arg
            3300                3305                3310        
Ala Ala Ser Cys Arg Ala Thr Ala Ala Trp Cys Thr Asp Ser Gly Ser
        3315                3320                3325            
Asp Asp Ser Arg Arg Trp Ser Asp Gln Leu Ser Leu Asp Glu Lys Asp
    3330                3335                3340                
Gly Phe Ile Phe Val Asn Tyr Ser Glu Gly Gln Thr Arg Ala His Leu
3345                3350                3355                3360
Gln Gly Pro Leu Ser His Pro His Pro Asn Pro Ile Glu Val Arg Asn
                3365                3370                3375    
Tyr Ser Arg Leu Lys Pro Gly Tyr Arg Trp Glu Arg Gln Leu Val Phe
            3380                3385                3390        
Arg Ser Lys Leu Thr Met His Thr Ala Phe Asp Arg Lys Asp Asn Ala
        3395                3400                3405            
His Pro Ala Glu Val Thr Ala Leu Gly Ile Ser Lys Asp His Ser Arg
    3410                3415                3420                
Ile Leu Val Gly Asp Ser Arg Gly Arg Val Phe Ser Trp Ser Val Ser
3425                3430                3435                3440
Asp Gln Pro Gly Arg Ser Ala Ala Asp His Trp Val Lys Asp Glu Gly
                3445                3450                3455    
Gly Asp Ser Cys Ser Gly Cys Ser Val Arg Phe Ser Leu Thr Glu Arg
            3460                3465                3470        
Arg His His Cys Arg Asn Cys Gly Gln Leu Phe Cys Gln Lys Cys Ser
        3475                3480                3485            
Arg Phe Gln Ser Glu Ile Lys Arg Leu Lys Ile Ser Ser Pro Val Arg
    3490                3495                3500                
Val Cys Gln Asn Cys Tyr Tyr Asn Leu Gln His Glu Arg Gly Ser Glu
3505                3510                3515                3520
Asp Gly Pro Arg Asn Cys
                3525    


<210> 6300
<211> 936
<212> PRT
<213> Homo sapiens

<400> 6300
Met Ala Leu Thr Gln Gly Pro Leu Thr Phe Arg Asp Val Ala Ile Glu
 1               5                  10                  15      
Phe Ser Gln Glu Glu Trp Lys Ser Leu Asp Pro Val Gln Lys Ala Leu
            20                  25                  30          
Tyr Trp Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly
        35                  40                  45              
Ile Leu Pro Lys Cys Met Thr Lys Glu Leu Pro Pro Ile Gly Asn Ser
    50                  55                  60                  
Asn Thr Gly Glu Lys Cys Gln Thr Val Thr Leu Glu Arg His Glu Cys
65                  70                  75                  80  
Tyr Asp Val Glu Asn Phe Tyr Leu Arg Glu Ile Gln Lys Asn Leu Gln
                85                  90                  95      
Asp Leu Glu Phe Gln Trp Lys Asp Gly Glu Ile Asn Tyr Lys Glu Val
            100                 105                 110         
Pro Met Thr Tyr Lys Asn Asn Leu Asn Gly Lys Arg Gly Gln His Ser
        115                 120                 125             
Gln Glu Asp Val Glu Asn Lys Cys Ile Glu Asn Gln Leu Thr Leu Ser
    130                 135                 140                 
Phe Gln Ser Arg Leu Thr Glu Leu Gln Lys Phe Gln Thr Glu Gly Lys
145                 150                 155                 160 
Ile Tyr Glu Cys Asn Gln Ser Glu Lys Thr Val Asn Asn Ser Ser Leu
                165                 170                 175     
Val Ser Pro Leu Gln Arg Ile Leu Pro Ser Val Gln Thr Asn Ile Ser
            180                 185                 190         
Lys Lys Tyr Glu Asn Glu Phe Leu Gln Leu Ser Leu Pro Thr Gln Leu
        195                 200                 205             
Glu Lys Thr His Ile Arg Glu Lys Pro Tyr Met Cys Lys Gly Cys Gly
    210                 215                 220                 
Lys Ala Phe Arg Val Ser Ser Ser Leu Ile Asn His Gln Met Val His
225                 230                 235                 240 
Thr Thr Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe His
                245                 250                 255     
Arg Gly Ser Leu Leu Thr Ile His Gln Ile Val His Thr Arg Gly Lys
            260                 265                 270         
Pro Tyr Gln Cys Gly Val Cys Gly Lys Ile Phe Arg Gln Asn Ser Asp
        275                 280                 285             
Leu Val Asn His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr Lys Cys
    290                 295                 300                 
Asn Glu Cys Gly Lys Ser Phe Ser Gln Ser Tyr Asn Leu Ala Ile His
305                 310                 315                 320 
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly
                325                 330                 335     
Lys Thr Phe Lys Gln Gly Ser Cys Leu Thr Thr His Gln Ile Ile His
            340                 345                 350         
Thr Gly Glu Lys Pro Tyr Gln Cys Asp Ile Cys Gly Lys Val Phe Arg
        355                 360                 365             
Gln Asn Ser Asn Leu Val Asn His Gln Arg Ile His Thr Gly Glu Lys
    370                 375                 380                 
Pro Tyr Lys Cys Asn Ile Cys Gly Lys Ser Phe Ser Gln Ser Ser Asn
385                 390                 395                 400 
Leu Ala Thr His Gln Thr Val His Ser Gly Asn Lys Pro Tyr Lys Cys
                405                 410                 415     
Asp Glu Cys Gly Lys Thr Phe Lys Arg Ser Ser Ser Leu Thr Thr His
            420                 425                 430         
Gln Ile Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Asp Val Cys Asp
        435                 440                 445             
Lys Val Phe Ser Gln Arg Ser Gln Leu Ala Arg His Gln Arg Ser His
    450                 455                 460                 
Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Ser
465                 470                 475                 480 
Gln Thr Ser His Leu Val Gly His Arg Arg Ile His Thr Gly Glu Lys
                485                 490                 495     
Pro Tyr Lys Cys Asp Lys Cys Gly Lys Ala Phe Lys Gln Gly Ser Leu
            500                 505                 510         
Leu Thr Arg His Lys Ile Ile His Thr Arg Glu Lys Arg Tyr Gln Cys
        515                 520                 525             
Gly Glu Cys Gly Lys Val Phe Ser Glu Asn Ser Cys Leu Val Arg His
    530                 535                 540                 
Leu Arg Ile His Thr Gly Glu Gln Pro Tyr Lys Cys Asn Val Cys Gly
545                 550                 555                 560 
Lys Val Phe Asn Tyr Ser Gly Asn Leu Ser Ile His Lys Arg Ile His
                565                 570                 575     
Thr Gly Glu Lys Pro Phe Gln Cys Asn Glu Cys Gly Thr Val Phe Arg
            580                 585                 590         
Asn Tyr Ser Cys Leu Ala Arg His Leu Arg Ile His Thr Gly Gln Lys
        595                 600                 605             
Pro Tyr Lys Cys Asn Val Cys Gly Lys Val Phe Asn Asp Ser Gly Asn
    610                 615                 620                 
Leu Ser Asn His Lys Arg Ile His Thr Gly Glu Lys Pro Phe Gln Cys
625                 630                 635                 640 
Asn Glu Cys Gly Lys Val Phe Ser Tyr Tyr Ser Cys Leu Ala Arg His
                645                 650                 655     
Arg Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Asp Cys Gly
            660                 665                 670         
Lys Ala Tyr Thr Gln Arg Ser Ser Leu Thr Lys His Leu Ile Ile His
        675                 680                 685             
Thr Gly Glu Lys Pro Tyr Asn Cys Asn Glu Phe Gly Gly Ala Phe Ile
    690                 695                 700                 
Gln Ser Ser Lys Leu Ala Arg Tyr His Arg Asn Pro Thr Gly Glu Lys
705                 710                 715                 720 
Pro His Lys Cys Ser His Cys Gly Arg Thr Phe Ser His Ile Thr Gly
                725                 730                 735     
Leu Thr Tyr His Gln Arg Arg His Thr Gly Glu Met Pro Tyr Lys Cys
            740                 745                 750         
Ile Glu Cys Gly Gln Val Phe Asn Ser Thr Ser Asn Leu Ala Arg His
        755                 760                 765             
Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly
    770                 775                 780                 
Lys Val Phe Arg His Gln Ser Thr Leu Ala Arg His Arg Ser Ile His
785                 790                 795                 800 
Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Arg
                805                 810                 815     
Val Arg Ser Ile Leu Val Asn His Gln Lys Met His Thr Gly Asp Lys
            820                 825                 830         
Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ile Glu Arg Ser Lys
        835                 840                 845             
Leu Val Tyr His Gln Arg Asn His Thr Gly Glu Lys Pro Tyr Lys Cys
    850                 855                 860                 
Ile Glu Cys Gly Lys Ala Phe Gly Arg Phe Ser Cys Leu Asn Lys His
865                 870                 875                 880 
Gln Met Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly
                885                 890                 895     
Lys Ser Phe Ile Ser Arg Ser Gly Leu Thr Lys His Gln Thr Lys His
            900                 905                 910         
Thr Ala Glu Ser Leu Lys Thr Lys Phe Asn Val Glu Lys Pro Leu Asp
        915                 920                 925             
Val Leu Leu Thr Ser Gly Phe Lys
    930                 935     


<210> 6301
<211> 220
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Any Amino Acid

<400> 6301
Thr Ser Trp Arg Arg Gly Glu Val Thr Pro Arg Arg Gly Ser Gly Gly
 1               5                  10                  15      
Gly Xaa Glu Thr Ile Gly Ala Lys Gln Gly Arg Thr Gln Leu Ser Ser
            20                  25                  30          
Gly Phe Val Asn Ser Thr Met Glu Glu Ala Gly Leu Cys Gly Leu Arg
        35                  40                  45              
Glu Lys Ala Asp Met Leu Cys Asn Ser Glu Ser His Asp Ile Leu Gln
    50                  55                  60                  
His Gln Asp Ser Asn Cys Ser Ala Thr Ser Asn Lys His Leu Leu Glu
65                  70                  75                  80  
Asp Glu Glu Gly Arg Asp Phe Ile Thr Lys Asn Arg Ser Trp Val Ser
                85                  90                  95      
Pro Val His Cys Thr Gln Glu Ser Arg Arg Glu Leu Pro Glu Gln Glu
            100                 105                 110         
Val Ala Pro Pro Ser Gly Gln Gln Ala Leu Gln Leu Gln Gln Glu Gln
        115                 120                 125             
Arg Lys Ser Leu Arg Lys Arg Ser Phe Ile Ile Asp Ala Ser Pro Lys
    130                 135                 140                 
His Ser Phe Arg Leu Gln Arg Arg Ser Trp Gln Leu Ser Val Arg Asn
145                 150                 155                 160 
Met Leu Ile Leu Glu Ile His Leu Phe Tyr Arg Arg Val Cys Phe Glu
                165                 170                 175     
Leu Tyr Asp Leu Lys Gln Asn Ser Phe Phe Gly Asp Tyr Gly Asn Ile
            180                 185                 190         
Leu Asn Arg Glu Thr Leu Leu Asp Phe Val Lys Gln Ile Met Glu Lys
        195                 200                 205             
Ile Gln Asn Phe Leu Lys Asn His Gly Lys Phe Leu
    210                 215                 220 


<210> 6302
<211> 3130
<212> PRT
<213> Homo sapiens

<400> 6302
Met Phe Ser Val Arg Ile Val Thr Ala Asp Tyr Tyr Met Ala Ser Pro
 1               5                  10                  15      
Leu Gln Gly Leu Asp Thr Cys Gln Ser Pro Leu Thr Gln Ala Pro Val
            20                  25                  30          
Lys Lys Val Pro Val Val Arg Val Phe Gly Ala Thr Pro Ala Gly Gln
        35                  40                  45              
Lys Thr Cys Leu His Leu His Gly Ile Phe Pro Tyr Leu Tyr Val Pro
    50                  55                  60                  
Tyr Asp Gly Tyr Gly Gln Gln Pro Glu Ser Tyr Leu Ser Gln Met Ala
65                  70                  75                  80  
Phe Ser Ile Asp Arg Ala Leu Asn Val Ala Leu Gly Asn Pro Ser Ser
                85                  90                  95      
Thr Ala Gln His Val Phe Lys Val Ser Leu Val Ser Gly Met Pro Phe
            100                 105                 110         
Tyr Gly Tyr His Glu Lys Glu Arg His Phe Met Lys Ile Tyr Leu Tyr
        115                 120                 125             
Asn Pro Thr Met Val Lys Arg Ile Cys Glu Leu Leu Gln Ser Gly Ala
    130                 135                 140                 
Ile Met Asn Lys Phe Tyr Gln Pro His Glu Ala His Ile Pro Tyr Leu
145                 150                 155                 160 
Leu Gln Leu Phe Ile Asp Tyr Asn Leu Tyr Gly Met Asn Leu Ile Asn
                165                 170                 175     
Leu Ala Ala Val Lys Phe Arg Lys Ala Arg Arg Lys Ser Asn Thr Leu
            180                 185                 190         
His Ala Thr Gly Ser Cys Lys Asn His Leu Ser Gly Asn Ser Leu Ala
        195                 200                 205             
Asp Thr Leu Phe Arg Trp Glu Gln Asp Glu Ile Pro Ser Ser Leu Ile
    210                 215                 220                 
Leu Glu Gly Val Glu Pro Gln Ser Thr Cys Glu Leu Glu Val Asp Ala
225                 230                 235                 240 
Val Ala Ala Asp Ile Leu Asn Arg Leu Asp Ile Glu Ala Gln Ile Gly
                245                 250                 255     
Gly Asn Pro Gly Leu Gln Ala Ile Trp Glu Asp Glu Lys Gln Arg Arg
            260                 265                 270         
Arg Asn Arg Asn Glu Thr Ser Gln Met Ser Gln Pro Glu Ser Gln Asp
        275                 280                 285             
His Arg Phe Val Pro Ala Thr Glu Ser Glu Lys Lys Phe Gln Lys Arg
    290                 295                 300                 
Leu Gln Glu Ile Leu Lys Gln Asn Asp Phe Ser Val Thr Leu Ser Gly
305                 310                 315                 320 
Ser Val Asp Tyr Ser Asp Gly Ser Gln Glu Phe Ser Ala Glu Leu Thr
                325                 330                 335     
Leu His Ser Glu Val Leu Ser Pro Glu Met Leu Gln Cys Thr Pro Ala
            340                 345                 350         
Asn Met Val Glu Val His Lys Asp Lys Glu Ser Ser Lys Gly His Thr
        355                 360                 365             
Arg His Lys Val Glu Glu Ala Leu Ile Asn Glu Glu Ala Ile Leu Asn
    370                 375                 380                 
Leu Met Glu Asn Ser Gln Thr Phe Gln Pro Leu Thr Gln Arg Leu Ser
385                 390                 395                 400 
Glu Ser Pro Val Phe Met Asp Ser Ser Pro Asp Glu Ala Leu Val His
                405                 410                 415     
Leu Leu Ala Gly Leu Glu Ser Asp Gly Tyr Arg Gly Glu Arg Asn Arg
            420                 425                 430         
Met Pro Ser Pro Cys Arg Ser Phe Gly Asn Asn Lys Tyr Pro Gln Asn
        435                 440                 445             
Ser Asp Asp Glu Glu Asn Glu Pro Gln Ile Glu Lys Glu Glu Met Glu
    450                 455                 460                 
Leu Ser Leu Val Met Ser Gln Arg Trp Asp Ser Asn Ile Glu Glu His
465                 470                 475                 480 
Cys Ala Lys Lys Arg Ser Leu Cys Arg Asn Thr His Arg Ser Ser Thr
                485                 490                 495     
Glu Asp Asp Asp Ser Ser Ser Gly Glu Glu Met Glu Trp Ser Asp Asn
            500                 505                 510         
Ser Leu Leu Leu Ala Ser Leu Ser Ile Pro Gln Leu Asp Gly Thr Ala
        515                 520                 525             
Asp Glu Asn Ser Asp Asn Pro Leu Asn Asn Glu Asn Ser Arg Thr His
    530                 535                 540                 
Ser Ser Val Ile Ala Thr Ser Lys Leu Ser Val Lys Pro Ser Ile Phe
545                 550                 555                 560 
His Lys Asp Ala Ala Thr Leu Glu Pro Ser Ser Ser Ala Lys Ile Thr
                565                 570                 575     
Phe Gln Cys Lys His Thr Ser Ala Leu Ser Ser His Val Leu Asn Lys
            580                 585                 590         
Glu Asp Leu Ile Glu Asp Leu Ser Gln Thr Asn Lys Asn Thr Glu Lys
        595                 600                 605             
Gly Leu Asp Asn Ser Val Thr Ser Phe Thr Asn Glu Ser Thr Tyr Ser
    610                 615                 620                 
Met Lys Tyr Pro Gly Ser Leu Ser Ser Thr Val His Ser Glu Asn Ser
625                 630                 635                 640 
His Lys Glu Asn Ser Lys Lys Glu Ile Leu Pro Val Ser Ser Cys Glu
                645                 650                 655     
Ser Ser Ile Phe Asp Tyr Glu Glu Asp Ile Pro Ser Val Thr Arg Gln
            660                 665                 670         
Val Pro Ser Arg Lys Tyr Thr Asn Ile Arg Lys Ile Glu Lys Asp Ser
        675                 680                 685             
Pro Phe Ile His Met His Arg His Pro Asn Glu Asn Thr Leu Gly Lys
    690                 695                 700                 
Asn Ser Phe Asn Phe Ser Asp Leu Asn His Ser Lys Asn Lys Val Ser
705                 710                 715                 720 
Ser Glu Gly Asn Glu Lys Gly Asn Ser Thr Ala Leu Ser Ser Leu Phe
                725                 730                 735     
Pro Ser Ser Phe Thr Glu Asn Cys Glu Leu Leu Ser Cys Ser Gly Glu
            740                 745                 750         
Asn Arg Thr Met Val His Ser Leu Asn Ser Thr Ala Asp Glu Ser Gly
        755                 760                 765             
Leu Asn Lys Leu Lys Ile Arg Tyr Glu Glu Phe Gln Glu His Lys Thr
    770                 775                 780                 
Glu Lys Pro Ser Leu Ser Gln Gln Ala Ala His Tyr Met Phe Phe Pro
785                 790                 795                 800 
Ser Val Val Leu Ser Asn Cys Leu Thr Arg Pro Gln Lys Leu Ser Pro
                805                 810                 815     
Val Thr Tyr Lys Leu Gln Pro Gly Asn Lys Pro Ser Arg Leu Lys Leu
            820                 825                 830         
Asn Lys Arg Lys Leu Ala Gly His Gln Glu Thr Ser Thr Lys Ser Ser
        835                 840                 845             
Glu Thr Gly Ser Thr Lys Asp Asn Phe Ile Gln Asn Asn Pro Cys Asn
    850                 855                 860                 
Ser Asn Pro Glu Lys Asp Asn Ala Leu Ala Ser Asp Leu Thr Lys Thr
865                 870                 875                 880 
Thr Arg Gly Ala Phe Glu Asn Lys Thr Pro Thr Asp Gly Phe Ile Asp
                885                 890                 895     
Cys His Phe Gly Asp Gly Thr Leu Glu Thr Glu Gln Ser Phe Gly Leu
            900                 905                 910         
Tyr Gly Asn Lys Tyr Thr Leu Arg Ala Lys Arg Lys Val Asn Tyr Glu
        915                 920                 925             
Thr Glu Asp Ser Glu Ser Ser Phe Val Thr His Asn Ser Lys Ile Ser
    930                 935                 940                 
Leu Pro His Pro Met Glu Ile Gly Glu Ser Leu Asp Gly Thr Leu Lys
945                 950                 955                 960 
Ser Arg Lys Arg Arg Lys Met Ser Lys Lys Leu Pro Pro Val Ile Ile
                965                 970                 975     
Lys Tyr Ile Ile Ile Asn Arg Phe Arg Gly Arg Lys Asn Met Leu Val
            980                 985                 990         
Lys Leu Gly Lys Ile Asp Ser Lys Glu Lys Gln Val Ile Leu Thr Glu
        995                 1000                1005            
Glu Lys Met Glu Leu Tyr Lys Lys Leu Ala Pro Leu Lys Asp Phe Trp
    1010                1015                1020                
Pro Lys Val Pro Asp Ser Pro Ala Thr Lys Tyr Pro Ile Tyr Pro Leu
1025                1030                1035                1040
Thr Pro Lys Lys Ser His Arg Arg Lys Ser Lys His Lys Ser Ala Lys
                1045                1050                1055    
Lys Lys Thr Gly Lys Gln Gln Arg Thr Asn Asn Glu Asn Ile Lys Arg
            1060                1065                1070        
Thr Leu Ser Phe Arg Lys Lys Arg Ser His Ala Ile Leu Ser Pro Pro
        1075                1080                1085            
Ser Pro Ser Tyr Asn Ala Glu Thr Glu Asp Cys Asp Leu Asn Tyr Ser
    1090                1095                1100                
Asp Val Met Ser Lys Leu Gly Phe Leu Ser Glu Arg Ser Thr Ser Pro
1105                1110                1115                1120
Ile Asn Ser Ser Pro Pro Arg Cys Trp Ser Pro Thr Asp Pro Arg Ala
                1125                1130                1135    
Glu Glu Ile Met Ala Ala Ala Glu Lys Glu Ala Met Leu Phe Lys Gly
            1140                1145                1150        
Pro Asn Val Tyr Lys Lys Thr Val Asn Ser Arg Ile Gly Lys Thr Ser
        1155                1160                1165            
Arg Ala Arg Ala Gln Ile Lys Lys Ser Lys Ala Lys Leu Ala Asn Pro
    1170                1175                1180                
Ser Ile Val Thr Lys Lys Arg Asn Lys Arg Asn Gln Thr Asn Lys Leu
1185                1190                1195                1200
Val Asp Asp Gly Lys Lys Lys Pro Arg Ala Lys Gln Lys Thr Asn Glu
                1205                1210                1215    
Lys Gly Thr Ser Arg Lys His Ile Thr Leu Lys Asp Glu Lys Ile Lys
            1220                1225                1230        
Ser Gln Ser Gly Ala Glu Val Lys Phe Val Leu Lys His Gln Asn Val
        1235                1240                1245            
Ser Glu Phe Ala Ser Ser Ser Gly Gly Ser Gln Leu Leu Phe Lys Gln
    1250                1255                1260                
Lys Asp Met Pro Leu Met Gly Ser Ala Val Asp His Pro Leu Ser Ala
1265                1270                1275                1280
Ser Leu Pro Thr Gly Ile Asn Ala Gln Gln Lys Leu Ser Gly Cys Phe
                1285                1290                1295    
Ser Ser Phe Leu Glu Ser Lys Lys Ser Val Asp Leu Gln Thr Phe Pro
            1300                1305                1310        
Ser Ser Arg Asp Asp Leu His Pro Ser Val Val Cys Asn Ser Ile Gly
        1315                1320                1325            
Pro Gly Val Ser Lys Ile Asn Val Gln Arg Pro His Asn Gln Ser Ala
    1330                1335                1340                
Met Phe Thr Leu Lys Glu Ser Thr Leu Ile Gln Lys Asn Ile Phe Asp
1345                1350                1355                1360
Leu Ser Asn His Leu Ser Gln Val Ala Gln Asn Thr Gln Ile Ser Ser
                1365                1370                1375    
Gly Met Ser Ser Lys Ile Glu Asp Asn Ala Asn Asn Ile Gln Arg Asn
            1380                1385                1390        
Tyr Leu Ser Ser Ile Gly Lys Leu Ser Glu Tyr Arg Asn Ser Leu Glu
        1395                1400                1405            
Ser Lys Leu Asp Gln Ala Tyr Thr Pro Asn Phe Leu His Cys Lys Asp
    1410                1415                1420                
Ser Gln Gln Gln Ile Val Cys Ile Ala Glu Gln Ser Lys His Ser Glu
1425                1430                1435                1440
Thr Cys Ser Pro Gly Asn Thr Ala Ser Glu Glu Ser Gln Met Pro Asn
                1445                1450                1455    
Asn Cys Phe Val Thr Ser Leu Arg Ser Pro Ile Lys Gln Ile Ala Trp
            1460                1465                1470        
Glu Gln Lys Gln Arg Gly Phe Ile Leu Asp Met Ser Asn Phe Lys Pro
        1475                1480                1485            
Glu Arg Val Lys Pro Arg Ser Leu Ser Glu Ala Ile Ser Gln Thr Lys
    1490                1495                1500                
Ala Leu Ser Gln Cys Lys Asn Arg Asn Val Ser Thr Pro Ser Ala Phe
1505                1510                1515                1520
Gly Glu Gly Gln Ser Gly Leu Ala Val Leu Lys Glu Leu Leu Gln Lys
                1525                1530                1535    
Arg Gln Gln Lys Ala Gln Asn Ala Asn Thr Thr Gln Asp Pro Leu Ser
            1540                1545                1550        
Asn Lys His Gln Pro Asn Lys Asn Ile Ser Gly Ser Leu Glu His Asn
        1555                1560                1565            
Lys Ala Asn Lys Arg Thr Arg Ser Val Thr Ser Pro Arg Lys Pro Arg
    1570                1575                1580                
Thr Pro Arg Ser Thr Lys Gln Lys Glu Lys Ile Pro Lys Leu Leu Lys
1585                1590                1595                1600
Val Asp Ser Leu Asn Leu Gln Asn Ser Ser Gln Leu Asp Asn Ser Val
                1605                1610                1615    
Ser Asp Asp Ser Pro Ile Phe Phe Ser Asp Pro Gly Phe Glu Ser Cys
            1620                1625                1630        
Tyr Ser Leu Glu Asp Ser Leu Ser Pro Glu His Asn Tyr Asn Phe Asp
        1635                1640                1645            
Ile Asn Thr Ile Gly Gln Thr Gly Phe Cys Ser Phe Tyr Ser Gly Ser
    1650                1655                1660                
Gln Phe Val Pro Ala Asp Gln Asn Leu Pro Gln Lys Phe Leu Ser Asp
1665                1670                1675                1680
Ala Val Gln Asp Leu Phe Pro Gly Gln Ala Ile Glu Lys Asn Glu Phe
                1685                1690                1695    
Leu Ser His Asp Asn Gln Lys Cys Asp Glu Asp Lys His His Thr Thr
            1700                1705                1710        
Asp Ser Ala Ser Trp Ile Arg Ser Gly Thr Leu Ser Pro Glu Ile Phe
        1715                1720                1725            
Glu Lys Ser Thr Ile Asp Ser Asn Glu Asn Arg Arg His Asn Gln Trp
    1730                1735                1740                
Lys Asn Ser Phe His Pro Leu Thr Thr Arg Ser Asn Ser Ile Met Asp
1745                1750                1755                1760
Ser Phe Cys Val Gln Gln Ala Glu Asp Cys Leu Ser Glu Lys Ser Arg
                1765                1770                1775    
Leu Asn Arg Ser Ser Val Ser Lys Glu Val Phe Leu Ser Leu Pro Gln
            1780                1785                1790        
Pro Asn Asn Ser Asp Trp Ile Gln Gly His Thr Arg Lys Glu Met Gly
        1795                1800                1805            
Gln Ser Leu Asp Ser Ala Asn Thr Ser Phe Thr Ala Ile Leu Ser Ser
    1810                1815                1820                
Pro Asp Gly Glu Leu Val Asp Val Ala Cys Glu Asp Leu Glu Leu Tyr
1825                1830                1835                1840
Val Ser Arg Asn Asn Asp Met Leu Thr Pro Thr Pro Asp Ser Ser Pro
                1845                1850                1855    
Arg Ser Thr Ser Ser Pro Ser Gln Ser Lys Asn Gly Ser Phe Thr Pro
            1860                1865                1870        
Arg Thr Ala Asn Ile Leu Lys Pro Leu Met Ser Pro Pro Ser Arg Glu
        1875                1880                1885            
Glu Ile Met Ala Thr Leu Leu Asp His Asp Leu Ser Glu Thr Ile Tyr
    1890                1895                1900                
Gln Glu Pro Phe Cys Ser Asn Pro Ser Asp Val Pro Glu Lys Pro Arg
1905                1910                1915                1920
Glu Ile Gly Gly Arg Leu Leu Met Val Glu Thr Arg Leu Ala Asn Asp
                1925                1930                1935    
Leu Ala Glu Phe Glu Gly Asp Phe Ser Leu Glu Gly Leu Arg Leu Trp
            1940                1945                1950        
Lys Thr Ala Phe Ser Ala Met Thr Gln Asn Pro Arg Pro Gly Ser Pro
        1955                1960                1965            
Leu Arg Ser Gly Gln Gly Val Val Asn Lys Gly Ser Ser Asn Ser Pro
    1970                1975                1980                
Lys Met Val Glu Asp Lys Lys Ile Val Ile Met Pro Cys Lys Cys Ala
1985                1990                1995                2000
Pro Ser Arg Gln Leu Val Gln Val Trp Leu Gln Ala Lys Glu Glu Tyr
                2005                2010                2015    
Glu Arg Ser Lys Lys Leu Pro Lys Thr Lys Pro Thr Gly Val Val Lys
            2020                2025                2030        
Ser Ala Glu Asn Phe Ser Ser Ser Val Asn Pro Asp Asp Lys Pro Val
        2035                2040                2045            
Val Pro Pro Lys Met Asp Val Ser Pro Cys Ile Leu Pro Thr Thr Ala
    2050                2055                2060                
His Thr Lys Glu Asp Val Asp Asn Ser Gln Ile Ala Leu Gln Ala Pro
2065                2070                2075                2080
Thr Thr Gly Cys Ser Gln Thr Ala Ser Glu Ser Gln Met Leu Pro Pro
                2085                2090                2095    
Val Ala Ser Ala Ser Asp Pro Glu Lys Asp Glu Asp Asp Asp Asp Asn
            2100                2105                2110        
Tyr Tyr Ile Ser Tyr Ser Ser Pro Asp Ser Pro Val Ile Pro Pro Trp
        2115                2120                2125            
Gln Gln Pro Ile Ser Pro Asp Ser Lys Ala Leu Asn Gly Asp Asp Arg
    2130                2135                2140                
Pro Ser Ser Pro Val Glu Glu Leu Pro Ser Leu Ala Phe Glu Asn Phe
2145                2150                2155                2160
Leu Lys Pro Ile Lys Asp Gly Ile Gln Lys Ser Pro Cys Ser Glu Pro
                2165                2170                2175    
Gln Glu Pro Leu Val Ile Ser Pro Ile Asn Thr Arg Ala Arg Thr Gly
            2180                2185                2190        
Lys Cys Glu Ser Leu Cys Phe His Ser Thr Pro Ile Ile Gln Arg Lys
        2195                2200                2205            
Leu Leu Glu Arg Leu Pro Glu Ala Pro Gly Leu Ser Pro Leu Ser Thr
    2210                2215                2220                
Glu Pro Lys Thr Gln Lys Leu Ser Asn Lys Lys Gly Ser Asn Thr Asp
2225                2230                2235                2240
Thr Leu Arg Arg Val Leu Leu Thr Gln Ala Lys Asn Gln Phe Ala Ala
                2245                2250                2255    
Val Asn Thr Pro Gln Lys Glu Thr Ser Gln Ile Asp Gly Pro Ser Leu
            2260                2265                2270        
Asn Asn Thr Tyr Gly Phe Lys Val Ser Ile Gln Asn Leu Gln Glu Ala
        2275                2280                2285            
Lys Ala Leu His Glu Ile Gln Asn Leu Thr Leu Ile Ser Val Glu Leu
    2290                2295                2300                
His Ala Arg Thr Arg Arg Asp Leu Glu Pro Asp Pro Glu Phe Asp Pro
2305                2310                2315                2320
Ile Cys Ala Leu Phe Tyr Cys Ile Ser Ser Asp Thr Pro Leu Pro Asp
                2325                2330                2335    
Thr Glu Lys Thr Glu Leu Thr Gly Val Ile Val Ile Asp Lys Asp Lys
            2340                2345                2350        
Thr Val Phe Ser Gln Asp Ile Arg Tyr Gln Thr Pro Leu Leu Ile Arg
        2355                2360                2365            
Ser Gly Ile Thr Gly Leu Glu Val Thr Tyr Ala Ala Asp Glu Lys Ala
    2370                2375                2380                
Leu Phe His Glu Ile Ala Asn Ile Ile Lys Arg Tyr Asp Pro Asp Ile
2385                2390                2395                2400
Leu Leu Gly Tyr Glu Ile Gln Met His Ser Trp Gly Tyr Leu Leu Gln
                2405                2410                2415    
Arg Ala Ala Ala Leu Ser Ile Asp Leu Cys Arg Met Ile Ser Arg Val
            2420                2425                2430        
Pro Asp Asp Lys Ile Glu Asn Arg Phe Ala Ala Glu Arg Asp Glu Tyr
        2435                2440                2445            
Gly Ser Tyr Thr Met Ser Glu Ile Asn Ile Val Gly Arg Ile Thr Leu
    2450                2455                2460                
Asn Leu Trp Arg Ile Met Arg Asn Glu Val Ala Leu Thr Asn Tyr Thr
2465                2470                2475                2480
Phe Glu Asn Val Ser Phe His Val Leu His Gln Arg Phe Pro Leu Phe
                2485                2490                2495    
Thr Phe Arg Val Leu Ser Asp Trp Phe Asp Asn Lys Thr Asp Leu Tyr
            2500                2505                2510        
Arg Trp Lys Met Val Asp His Tyr Val Ser Arg Val Arg Gly Asn Leu
        2515                2520                2525            
Gln Met Leu Glu Gln Leu Asp Leu Ile Gly Lys Thr Ser Glu Met Ala
    2530                2535                2540                
Arg Leu Phe Gly Ile Gln Phe Leu His Val Leu Thr Arg Gly Ser Gln
2545                2550                2555                2560
Tyr Arg Val Glu Ser Met Met Leu Arg Ile Ala Lys Pro Met Asn Tyr
                2565                2570                2575    
Ile Pro Val Thr Pro Ser Val Gln Gln Arg Ser Gln Met Arg Ala Pro
            2580                2585                2590        
Gln Cys Val Pro Leu Ile Met Glu Pro Glu Ser Arg Phe Tyr Ser Asn
        2595                2600                2605            
Ser Val Leu Val Leu Asp Phe Gln Ser Leu Tyr Pro Ser Ile Val Ile
    2610                2615                2620                
Ala Tyr Asn Tyr Cys Phe Ser Thr Cys Leu Gly His Val Glu Asn Leu
2625                2630                2635                2640
Gly Lys Tyr Asp Glu Phe Lys Phe Gly Cys Thr Ser Leu Arg Val Pro
                2645                2650                2655    
Pro Asp Leu Leu Tyr Gln Val Arg His Asp Ile Thr Val Ser Pro Asn
            2660                2665                2670        
Gly Val Ala Phe Val Lys Pro Ser Val Arg Lys Gly Val Leu Pro Arg
        2675                2680                2685            
Met Leu Glu Glu Ile Leu Lys Thr Arg Phe Met Val Lys Gln Ser Met
    2690                2695                2700                
Lys Ala Tyr Lys Gln Asp Arg Ala Leu Ser Arg Met Leu Asp Ala Arg
2705                2710                2715                2720
Gln Leu Gly Leu Lys Leu Ile Ala Asn Val Thr Phe Gly Tyr Thr Ser
                2725                2730                2735    
Ala Asn Phe Ser Gly Arg Met Pro Cys Ile Glu Val Gly Asp Ser Ile
            2740                2745                2750        
Val His Lys Ala Arg Glu Thr Leu Glu Arg Ala Ile Lys Leu Val Asn
        2755                2760                2765            
Asp Thr Lys Lys Trp Gly Ala Arg Val Val Tyr Gly Asp Thr Asp Ser
    2770                2775                2780                
Met Phe Val Leu Leu Lys Gly Ala Thr Lys Glu Gln Ser Phe Lys Ile
2785                2790                2795                2800
Gly Gln Glu Ile Ala Glu Ala Val Thr Ala Thr Asn Pro Lys Pro Val
                2805                2810                2815    
Lys Leu Lys Phe Glu Lys Val Tyr Leu Pro Cys Val Leu Gln Thr Lys
            2820                2825                2830        
Lys Arg Tyr Val Gly Tyr Met Tyr Glu Thr Leu Asp Gln Lys Asp Pro
        2835                2840                2845            
Val Phe Asp Ala Lys Gly Ile Glu Thr Val Arg Arg Asp Ser Cys Pro
    2850                2855                2860                
Ala Val Ser Lys Ile Leu Glu Arg Ser Leu Lys Leu Leu Phe Glu Thr
2865                2870                2875                2880
Arg Asp Ile Ser Leu Ile Lys Gln Tyr Val Gln Arg Gln Cys Met Lys
                2885                2890                2895    
Leu Leu Glu Gly Lys Ala Ser Ile Gln Asp Phe Ile Phe Ala Lys Glu
            2900                2905                2910        
Tyr Arg Gly Ser Phe Ser Tyr Lys Pro Gly Ala Cys Val Pro Ala Leu
        2915                2920                2925            
Glu Leu Thr Arg Lys Met Leu Thr Tyr Asp Arg Arg Ser Glu Pro Gln
    2930                2935                2940                
Val Gly Glu Arg Val Pro Tyr Val Ile Ile Tyr Gly Thr Pro Gly Val
2945                2950                2955                2960
Pro Leu Ile Gln Leu Val Arg Arg Pro Val Glu Val Leu Gln Asp Pro
                2965                2970                2975    
Thr Leu Arg Leu Asn Ala Thr Tyr Tyr Ile Thr Lys Gln Ile Leu Pro
            2980                2985                2990        
Pro Leu Ala Arg Ile Phe Ser Leu Ile Gly Ile Asp Val Phe Ser Trp
        2995                3000                3005            
Tyr His Glu Leu Pro Arg Ile His Lys Ala Thr Ser Ser Ser Arg Ser
    3010                3015                3020                
Glu Pro Glu Gly Arg Lys Gly Thr Ile Ser Gln Tyr Phe Thr Thr Leu
3025                3030                3035                3040
His Cys Pro Val Cys Asp Asp Leu Thr Gln His Gly Ile Cys Ser Lys
                3045                3050                3055    
Cys Arg Ser Gln Pro Gln His Val Ala Val Ile Leu Asn Gln Glu Ile
            3060                3065                3070        
Arg Glu Leu Glu Arg Gln Gln Glu Gln Leu Val Lys Ile Cys Lys Asn
        3075                3080                3085            
Cys Thr Gly Cys Phe Asp Arg His Ile Pro Cys Val Ser Leu Asn Cys
    3090                3095                3100                
Pro Val Leu Phe Lys Leu Ser Arg Val Asn Arg Glu Leu Ser Lys Ala
3105                3110                3115                3120
Pro Tyr Leu Arg Gln Leu Leu Asp Gln Phe
                3125                3130


<210> 6303
<211> 762
<212> PRT
<213> Homo sapiens

<400> 6303
Met Glu Lys Leu Glu Val Leu Glu Glu Trp Gln Ser His Ile Glu Gly
 1               5                  10                  15      
Trp Glu Gly Ser Asn Ile Thr Asp Thr Cys Thr Glu Met Leu Met Cys
            20                  25                  30          
Gly Val Leu Leu Lys Ile Ser Ser Gly Asn Ile Gln Glu Arg Val Phe
        35                  40                  45              
Phe Leu Phe Asp Asn Leu Leu Val Tyr Cys Lys Arg Lys His Arg Arg
    50                  55                  60                  
Leu Lys Asn Ser Lys Ala Ser Thr Asp Gly His Arg Tyr Leu Phe Arg
65                  70                  75                  80  
Gly Arg Ile Asn Thr Glu Val Met Glu Val Glu Asn Val Asp Asp Gly
                85                  90                  95      
Thr Ala Asp Phe His Ser Ser Gly His Ile Val Val Asn Gly Trp Lys
            100                 105                 110         
Ile His Asn Thr Ala Lys Asn Lys Trp Phe Val Cys Met Ala Lys Thr
        115                 120                 125             
Pro Glu Glu Lys His Glu Trp Phe Glu Ala Ile Leu Lys Glu Arg Glu
    130                 135                 140                 
Arg Arg Lys Gly Leu Lys Leu Gly Met Glu Gln Asp Thr Trp Val Met
145                 150                 155                 160 
Ile Ser Glu Gln Gly Glu Lys Leu Tyr Lys Met Met Cys Arg Gln Gly
                165                 170                 175     
Asn Leu Ile Lys Asp Arg Lys Arg Lys Leu Thr Thr Phe Pro Lys Cys
            180                 185                 190         
Phe Leu Gly Ser Glu Phe Val Ser Trp Leu Leu Glu Ile Gly Glu Ile
        195                 200                 205             
His Arg Pro Glu Glu Gly Val His Leu Gly Gln Ala Leu Leu Glu Asn
    210                 215                 220                 
Gly Ile Ile His His Val Thr Asp Lys His Gln Phe Lys Pro Glu Gln
225                 230                 235                 240 
Met Leu Tyr Arg Phe Arg Tyr Asp Asp Gly Thr Phe Tyr Pro Arg Asn
                245                 250                 255     
Glu Met Gln Asp Val Ile Ser Lys Gly Val Arg Leu Tyr Cys Arg Leu
            260                 265                 270         
His Ser Leu Phe Thr Pro Val Ile Arg Asp Lys Asp Tyr His Leu Arg
        275                 280                 285             
Thr Tyr Lys Ser Val Val Met Ala Asn Lys Leu Ile Asp Trp Leu Ile
    290                 295                 300                 
Ala Gln Gly Asp Cys Arg Thr Arg Glu Glu Ala Met Ile Phe Gly Val
305                 310                 315                 320 
Gly Leu Cys Asp Asn Gly Phe Met His His Val Leu Glu Lys Ser Glu
                325                 330                 335     
Phe Lys Asp Glu Pro Leu Leu Phe Arg Phe Phe Ser Asp Glu Glu Met
            340                 345                 350         
Glu Gly Ser Asn Met Lys His Arg Leu Met Lys His Asp Leu Lys Val
        355                 360                 365             
Val Glu Asn Val Ile Ala Lys Ser Leu Leu Ile Lys Ser Asn Glu Gly
    370                 375                 380                 
Ser Tyr Gly Phe Gly Leu Glu Asp Lys Asn Lys Val Pro Ile Ile Lys
385                 390                 395                 400 
Leu Val Glu Lys Gly Ser Asn Ala Glu Met Ala Gly Met Glu Val Gly
                405                 410                 415     
Lys Lys Ile Phe Ala Ile Asn Gly Asp Leu Val Phe Met Arg Pro Phe
            420                 425                 430         
Asn Glu Val Asp Cys Phe Leu Lys Ser Cys Leu Asn Ser Arg Lys Pro
        435                 440                 445             
Leu Arg Val Leu Val Ser Thr Lys Pro Arg Glu Thr Val Lys Ile Pro
    450                 455                 460                 
Asp Ser Ala Asp Gly Leu Gly Phe Gln Ile Arg Gly Phe Gly Pro Ser
465                 470                 475                 480 
Val Val His Ala Val Gly Arg Gly Thr Val Ala Ala Ala Ala Gly Leu
                485                 490                 495     
His Pro Gly Gln Cys Ile Ile Lys Val Asn Gly Ile Asn Val Ser Lys
            500                 505                 510         
Glu Thr His Ala Ser Val Ile Ala His Val Thr Ala Cys Arg Lys Tyr
        515                 520                 525             
Arg Arg Pro Thr Lys Gln Asp Ser Ile Gln Trp Val Tyr Asn Ser Ile
    530                 535                 540                 
Glu Ser Ala Gln Glu Asp Leu Gln Lys Ser His Ser Lys Pro Pro Gly
545                 550                 555                 560 
Asp Glu Ala Gly Asp Ala Phe Asp Cys Lys Val Glu Glu Val Ile Asp
                565                 570                 575     
Lys Phe Asn Thr Met Ala Ile Ile Asp Gly Lys Lys Glu His Val Ser
            580                 585                 590         
Leu Thr Val Asp Asn Val His Leu Glu Tyr Gly Val Val Tyr Glu Tyr
        595                 600                 605             
Asp Ser Thr Ala Gly Ile Lys Cys Asn Val Val Glu Lys Met Ile Glu
    610                 615                 620                 
Pro Lys Gly Phe Phe Ser Leu Thr Ala Lys Ile Leu Glu Ala Leu Ala
625                 630                 635                 640 
Lys Ser Asp Glu His Phe Val Gln Asn Cys Thr Ser Leu Asn Ser Leu
                645                 650                 655     
Asn Glu Val Ile Pro Thr Asp Leu Gln Ser Lys Phe Ser Ala Leu Cys
            660                 665                 670         
Ser Glu Arg Ile Glu His Leu Cys Gln Arg Ile Ser Ser Tyr Lys Lys
        675                 680                 685             
Val Gln Ala Ser Glu Arg Phe Tyr Asn Phe Thr Ala Arg His Ala Val
    690                 695                 700                 
Trp Glu His Ser Phe Asp Leu His Ser Val Ser Ser Thr Phe Pro Val
705                 710                 715                 720 
Pro Val Thr Met Glu Phe Leu Leu Leu Pro Pro Pro Leu Leu Gly Ile
                725                 730                 735     
Ser Gln Asp Gly Arg Gln His Cys Ile Pro Glu Asp Leu Pro Ser Gln
            740                 745                 750         
Glu Met Leu Leu Ala Glu Arg Ala Pro Val
        755                 760         


<210> 6304
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 6304
Met Glu Gly Ser Asn Met Lys His Arg Leu Met Lys His Asp Leu Lys
 1               5                  10                  15      
Val Val Glu Asn Val Ile Ala Lys Ser Leu Leu Ile Lys Ser Asn Glu
            20                  25                  30          
Gly Ser Tyr Gly Phe Gly Leu Glu Asp Lys Asn Lys Val Pro Ile Ile
        35                  40                  45              
Lys Leu Val Glu Lys Gly Ser Asn Ala Glu Met Ala Gly Met Glu Val
    50                  55                  60                  
Gly Lys Lys Ile Phe Ala Ile Asn Gly Asp Leu Val Phe Met Arg Pro
65                  70                  75                  80  
Phe Asn Glu Val Asp Cys Phe Leu Lys Ser Cys Leu Asn Ser Arg Lys
                85                  90                  95      
Pro Leu Arg Val Leu Val Ser Thr Lys Pro Arg Glu Thr Val Lys Ile
            100                 105                 110         
Pro Asp Ser Ala Asp Gly Leu Gly Phe Gln Ile Arg Gly Phe Gly Pro
        115                 120                 125             
Ser Val Val His Ala Val Gly Arg Gly Thr Val Ala Ala Ala Ala Gly
    130                 135                 140                 
Leu His Pro Gly Gln Cys Ile Ile Lys Val Asn Gly Ile Asn Val Ser
145                 150                 155                 160 
Lys Glu Thr His Ala Ser Val Ile Ala His Val Thr Ala Cys Arg Lys
                165                 170                 175     
Tyr Arg Arg Pro Thr Lys Gln Asp Ser Ile Gln Trp Val Tyr Asn Ser
            180                 185                 190         
Ile Glu Ser Ala Gln Glu Asp Leu Gln Lys Ser His Ser Lys Pro Pro
        195                 200                 205             
Gly Asp Glu Ala Gly Asp Ala Phe Asp Cys Lys Val Glu Glu Val Ile
    210                 215                 220                 
Asp Lys Phe Asn Thr Met Ala Ile Ile Asp Gly Lys Lys Glu His Val
225                 230                 235                 240 
Ser Leu Thr Val Asp Asn Val His Leu Glu Tyr Gly Val Val Tyr Glu
                245                 250                 255     
Tyr Asp Ser Thr Ala Gly Ile Lys Cys Asn Val Val Glu Lys Met Ile
            260                 265                 270         
Glu Pro Lys Gly Phe Phe Ser Leu Thr Ala Lys Ile Leu Glu Ala Leu
        275                 280                 285             
Ala Lys Ser Asp Glu His Phe Val Gln Asn Cys Thr Ser Leu Asn Ser
    290                 295                 300                 
Leu Asn Glu Val Ile Pro Thr Asp Leu Gln Ser Lys Phe Ser Ala Leu
305                 310                 315                 320 
Cys Ser Glu Arg Ile Glu His Leu Cys Gln Arg Ile Ser Ser Tyr Lys
                325                 330                 335     
Lys Phe Ser Arg Val Leu Lys Asn Arg Ala Trp Pro Thr Phe Lys Gln
            340                 345                 350         
Ala Lys Ser Lys Ile Ser Pro Leu His Ser Ser Asp Phe Cys Pro Thr
        355                 360                 365             
Asn Cys His Val Asn Val Met Glu Val Ser Tyr Pro Lys Thr Ser Thr
    370                 375                 380                 
Ser Leu Gly Ser Ala Phe Gly Val Gln Leu Asp Ser Arg Lys His Asn
385                 390                 395                 400 
Ser His Asp Lys Glu Asn Lys Ser Ser Glu Gln Gly Lys Leu Ser Pro
                405                 410                 415     
Met Val Tyr Ile Gln His Thr Ile Thr Thr Met Ala Ala Pro Ser Gly
            420                 425                 430         
Leu Ser Leu Gly Gln Gln Asp Gly His Gly Leu Arg Tyr Leu Leu Lys
        435                 440                 445             
Glu Glu Asp Leu Glu Thr Gln Asp Ile Tyr Gln Lys Leu Leu Gly Lys
    450                 455                 460                 
Leu Gln Thr Ala Leu Lys Glu Val Glu Met Cys Val Cys Gln Ile Asp
465                 470                 475                 480 
Asp Leu Leu Ser Ser Ile Thr Tyr Ser Pro Lys Leu Glu Arg Lys Thr
                485                 490                 495     
Ser Glu Gly Ile Ile Pro Thr Asp Ser Asp Asn Glu Lys Gly Glu Arg
            500                 505                 510         
Asn Ser Lys Arg Val Cys Phe Asn Val Ala Gly Asp Glu Gln Glu Asp
        515                 520                 525             
Ser Gly His Asp Thr Ile Ser Asn Arg Asp Ser Tyr Ser Asp Cys Asn
    530                 535                 540                 
Ser Asn Arg Asn Ser Ile Ala Ser Phe Thr Ser Ile Cys Ser Ser Gln
545                 550                 555                 560 
Cys Ser Ser Tyr Phe His Ser Asp Glu Met Asp Ser Gly Asp Glu Leu
                565                 570                 575     
Pro Leu Ser Val Arg Ile Ser His Asp Lys Gln Asp Lys Ile His Ser
            580                 585                 590         
Cys Leu Glu His Leu Phe Ser Gln Val Asp Ser Ile Thr Asn Leu Leu
        595                 600                 605             
Lys Gly Gln Ala Val Val Arg Ala Phe Asp Gln Thr Lys Tyr Leu Thr
    610                 615                 620                 
Pro Gly Arg Gly Leu Gln Glu Phe Gln Gln Glu Met Glu Pro Lys Leu
625                 630                 635                 640 
Ser Cys Pro Lys Arg Leu Arg Leu His Ile Lys Gln Asp Pro Trp Asn
                645                 650                 655     
Leu Pro Ser Ser Val Arg Thr Leu Ala Gln Asn Ile Arg Lys Phe Val
            660                 665                 670         
Glu Glu Val Lys Cys Arg Leu Leu Leu Ala Leu Leu Glu Tyr Ser Asp
        675                 680                 685             
Ser Glu Thr Gln Leu Arg Arg Asp Met Val Phe Cys Gln Thr Leu Val
    690                 695                 700                 
Ala Thr Val Cys Ala Phe Ser Glu Gln Leu Met Ala Ala Leu Asn Gln
705                 710                 715                 720 
Met Phe Asp Asn Ser Lys Glu Asn Glu Met Glu Thr Trp Glu Ala Ser
                725                 730                 735     
Arg Arg Trp Leu Asp Gln Ile Ala Asn Ala Gly Val Leu Phe His Phe
            740                 745                 750         
Gln Ser Leu Leu Ser Pro Asn Leu Thr Asp Glu Gln Ala Met Leu Glu
        755                 760                 765             
Asp Thr Leu Val Ala Leu Phe Asp Leu Glu Lys Val Ser Phe Tyr Phe
    770                 775                 780                 
Lys Pro Ser Glu Glu Glu Pro Leu Val Ala Asn Val Pro Leu Thr Tyr
785                 790                 795                 800 
Gln Ala Glu Gly Ser Arg Gln Ala Leu Lys Val Tyr Phe Tyr Ile Asp
                805                 810                 815     
Ser Tyr His Phe Glu Gln Leu Pro Gln Arg Leu Lys Asn Gly Gly Gly
            820                 825                 830         
Phe Lys Ile His Pro Val Leu Phe Ala Gln Ala Leu Glu Ser Met Glu
        835                 840                 845             
Gly Tyr Tyr Tyr Arg Asp Asn Val Ser Val Glu Glu Phe Gln Ala Gln
    850                 855                 860                 
Ile Asn Ala Ala Ser Leu Glu Lys Val Lys Gln Tyr Asn Gln Lys Leu
865                 870                 875                 880 
Arg Ala Phe Tyr Leu Asp Lys Ser Asn Ser Pro Pro Asn Ser Thr Ser
                885                 890                 895     
Lys Ala Ala Tyr Val Asp Lys Leu Met Arg Pro Leu Asn Ala Leu Asp
            900                 905                 910         
Glu Leu Tyr Arg Leu Val Ala Ser Phe Ile Arg Ser Lys Arg Thr Ala
        915                 920                 925             
Ala Cys Ala Asn Thr Ala Cys Ser Ala Ser Gly Val Gly Leu Leu Ser
    930                 935                 940                 
Val Ser Ser Glu Leu Cys Asn Arg Leu Gly Ala Cys His Ile Ile Met
945                 950                 955                 960 
Cys Ser Ser Gly Val His Arg Cys Thr Leu Ser Val Thr Leu Glu Gln
                965                 970                 975     
Ala Ile Ile Leu Ala Arg Ser His Gly Leu Pro Pro Arg Tyr Ile Met
            980                 985                 990         
Gln Ala Thr Asp Val Met Arg Lys Gln Gly Ala Arg Val Gln Asn Thr
        995                 1000                1005            
Ala Lys Asn Leu Gly Val Arg Asp Arg Thr Pro Gln Ser Ala Pro Arg
    1010                1015                1020                
Leu Tyr Lys Leu Cys Glu Pro Pro Pro Pro Ala Gly Glu Glu
1025                1030                1035            


<210> 6305
<211> 527
<212> PRT
<213> Homo sapiens

<400> 6305
Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln
 1               5                  10                  15      
Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly
            20                  25                  30          
Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu
        35                  40                  45              
Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys
    50                  55                  60                  
Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe
65                  70                  75                  80  
Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly
                85                  90                  95      
Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile
            100                 105                 110         
Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp
        115                 120                 125             
Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val
    130                 135                 140                 
Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser
145                 150                 155                 160 
Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala
                165                 170                 175     
Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala
            180                 185                 190         
Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val
        195                 200                 205             
Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu
    210                 215                 220                 
Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu
225                 230                 235                 240 
Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile
                245                 250                 255     
Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val
            260                 265                 270         
Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn
        275                 280                 285             
Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr
    290                 295                 300                 
Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser
305                 310                 315                 320 
Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys
                325                 330                 335     
Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu
            340                 345                 350         
Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser
        355                 360                 365             
Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe
    370                 375                 380                 
Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp
385                 390                 395                 400 
Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp
                405                 410                 415     
Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro
            420                 425                 430         
Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His
        435                 440                 445             
Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg
    450                 455                 460                 
Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu
465                 470                 475                 480 
His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro
                485                 490                 495     
Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys
            500                 505                 510         
Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp
        515                 520                 525         


<210> 6306
<211> 71
<212> PRT
<213> Homo sapiens

<400> 6306
Met Lys Ile Val His Val Asn Val Met Gly Val Gly Gly Trp Gly Ala
 1               5                  10                  15      
Val Phe Leu Asp Met Trp His Val Thr Gln Glu Ser Lys Arg Pro Ile
            20                  25                  30          
Ile Ser Lys Met Pro Ala Trp Ile Phe Pro Cys His Pro Leu Asp Glu
        35                  40                  45              
Gln Thr Tyr His Met Ala Leu Asn Ala Ala Thr Phe Pro Lys Asn Ala
    50                  55                  60                  
Thr Trp Ile Gly Pro Leu Trp
65                  70      


<210> 6307
<211> 79
<212> PRT
<213> Homo sapiens

<400> 6307
Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val
 1               5                  10                  15      
His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp
            20                  25                  30          
Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys
        35                  40                  45              
Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Gly Ser Val
    50                  55                  60                  
Asp Gln Asn His Ser Trp Leu Gly Arg Lys Arg Arg Asn Pro Asn
65                  70                  75                  


<210> 6308
<211> 391
<212> PRT
<213> Homo sapiens

<400> 6308
Ala Ala Gly Ala Pro Arg Leu Leu Gly Pro Gly Ala Val Arg Gly Pro
 1               5                  10                  15      
Ala Gly Val Gly Arg Val Ala Ala Gly Ala Met Glu Gly Val Leu Tyr
            20                  25                  30          
Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln Pro Arg Trp Phe Leu Leu
        35                  40                  45              
Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser Pro Glu Asp Ala Trp Lys
    50                  55                  60                  
Gly Cys Lys Gly Ser Ile Gln Met Ala Val Cys Glu Ile Gln Val His
65                  70                  75                  80  
Ser Val Asp Asn Thr Arg Met Asp Leu Ile Ile Pro Gly Glu Gln Tyr
                85                  90                  95      
Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu Arg Gln Arg Trp Leu Val
            100                 105                 110         
Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr Asp Ser Arg Thr Gln Lys
        115                 120                 125             
Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn Leu Lys Thr Lys Met Ser
    130                 135                 140                 
Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val Gln Gln Val Asp Lys Thr
145                 150                 155                 160 
Lys Glu Val Thr Thr Thr Gly Val Ser Asn Ser Glu Glu Gly Ile Asp
                165                 170                 175     
Val Gly Thr Leu Leu Lys Ser Thr Cys Asn Thr Phe Leu Lys Thr Leu
            180                 185                 190         
Glu Glu Cys Met Gln Ile Ala Asn Ala Ala Phe Thr Ser Glu Leu Leu
        195                 200                 205             
Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu Ala Met Leu Lys Ser Ser
    210                 215                 220                 
Lys Met Lys His Pro Ile Ile Pro Ile His Asn Ser Leu Glu Arg Gln
225                 230                 235                 240 
Met Glu Leu Ser Thr Cys Glu Asn Gly Ser Leu Asn Met Glu Ile Asn
                245                 250                 255     
Gly Glu Glu Glu Ile Leu Met Lys Asn Lys Asn Ser Leu Tyr Leu Lys
            260                 265                 270         
Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser Glu Glu Asn Thr Asp Asp
        275                 280                 285             
Asn Ile Thr Val Gln Gly Glu Ile Arg Lys Glu Asp Gly Met Glu Asn
    290                 295                 300                 
Leu Lys Asn His Asp Asn Asn Leu Thr Gln Ser Gly Ser Asp Ser Ser
305                 310                 315                 320 
Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly Lys Glu Val Ile Pro Thr
                325                 330                 335     
Phe Phe Ser Thr Met Asn Thr Ser Phe Ser Asp Ile Glu Leu Leu Glu
            340                 345                 350         
Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu Ala Ser Cys Tyr Ala Val
        355                 360                 365             
Val Pro Val Leu Asp Lys Leu Gly Pro Thr Val Phe Ala Pro Val Lys
    370                 375                 380                 
Asp Gly Ser Cys Trp Lys Tyr
385                 390     


<210> 6309
<211> 440
<212> PRT
<213> Homo sapiens

<400> 6309
Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln
 1               5                  10                  15      
Pro Arg Trp Phe Leu Leu Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser
            20                  25                  30          
Pro Glu Asp Ala Trp Lys Gly Cys Lys Gly Ser Ile Gln Met Ala Val
        35                  40                  45              
Cys Glu Ile Gln Val His Ser Val Asp Asn Thr Arg Met Asp Leu Ile
    50                  55                  60                  
Ile Pro Gly Glu Gln Tyr Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu
65                  70                  75                  80  
Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr
                85                  90                  95      
Asp Ser Arg Thr Gln Lys Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn
            100                 105                 110         
Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val
        115                 120                 125             
Gln Gln Val Asp Lys Thr Lys Glu Val Thr Thr Thr Gly Val Ser Asn
    130                 135                 140                 
Ser Glu Glu Gly Ile Asp Val Gly Thr Leu Leu Lys Ser Thr Cys Asn
145                 150                 155                 160 
Thr Phe Leu Lys Thr Leu Glu Glu Cys Met Gln Ile Ala Asn Ala Ala
                165                 170                 175     
Phe Thr Ser Glu Leu Leu Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu
            180                 185                 190         
Ala Met Leu Lys Ser Ser Lys Met Lys His Pro Ile Ile Pro Ile His
        195                 200                 205             
Asn Ser Leu Glu Arg Gln Met Glu Leu Ser Thr Cys Glu Asn Gly Ser
    210                 215                 220                 
Leu Asn Met Glu Ile Asn Gly Glu Glu Glu Ile Leu Met Lys Asn Lys
225                 230                 235                 240 
Asn Ser Leu Tyr Leu Lys Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser
                245                 250                 255     
Glu Glu Asn Thr Asp Asp Asn Ile Thr Val Gln Gly Glu Ile Arg Lys
            260                 265                 270         
Glu Asp Gly Met Glu Asn Leu Lys Asn His Asp Asn Asn Leu Thr Gln
        275                 280                 285             
Ser Gly Ser Asp Ser Ser Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly
    290                 295                 300                 
Lys Glu Val Ile Pro Thr Phe Phe Ser Thr Met Asn Thr Ser Phe Ser
305                 310                 315                 320 
Asp Ile Glu Leu Leu Glu Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu
                325                 330                 335     
Ala Ser Cys Tyr Ala Val Val Pro Val Leu Asp Lys Leu Gly Pro Thr
            340                 345                 350         
Val Phe Ala Pro Val Lys Met Asp Leu Val Gly Asn Ile Lys Lys Val
        355                 360                 365             
Asn Gln Lys Tyr Ile Thr Asn Lys Glu Glu Phe Thr Thr Leu Gln Lys
    370                 375                 380                 
Ile Val Leu His Glu Val Glu Ala Asp Val Ala Gln Val Arg Asn Ser
385                 390                 395                 400 
Ala Thr Glu Ala Leu Leu Trp Leu Lys Arg Gly Leu Lys Phe Leu Lys
                405                 410                 415     
Gly Phe Leu Thr Glu Val Lys Asn Gly Glu Lys Asp Ile Gln Thr Ala
            420                 425                 430         
Leu Arg Asn Pro Thr Glu Asn Thr
        435                 440 


<210> 6310
<211> 507
<212> PRT
<213> Homo sapiens

<400> 6310
Met Glu Gly Val Leu Tyr Lys Trp Thr Asn Tyr Leu Ser Gly Trp Gln
 1               5                  10                  15      
Pro Arg Trp Phe Leu Leu Cys Gly Gly Ile Leu Ser Tyr Tyr Asp Ser
            20                  25                  30          
Pro Glu Asp Ala Trp Lys Gly Cys Lys Gly Ser Ile Gln Met Ala Val
        35                  40                  45              
Cys Glu Ile Gln Val His Ser Val Asp Asn Thr Arg Met Asp Leu Ile
    50                  55                  60                  
Ile Pro Gly Glu Gln Tyr Phe Tyr Leu Lys Ala Arg Ser Val Ala Glu
65                  70                  75                  80  
Arg Gln Arg Trp Leu Val Ala Leu Gly Ser Ala Lys Ala Cys Leu Thr
                85                  90                  95      
Asp Ser Arg Thr Gln Lys Glu Lys Glu Phe Ala Glu Asn Thr Glu Asn
            100                 105                 110         
Leu Lys Thr Lys Met Ser Glu Leu Arg Leu Tyr Cys Asp Leu Leu Val
        115                 120                 125             
Gln Gln Val Asp Lys Thr Lys Glu Val Thr Thr Thr Gly Val Ser Asn
    130                 135                 140                 
Ser Glu Glu Gly Ile Asp Val Gly Thr Leu Leu Lys Ser Thr Cys Asn
145                 150                 155                 160 
Thr Phe Leu Lys Thr Leu Glu Glu Cys Met Gln Ile Ala Asn Ala Ala
                165                 170                 175     
Phe Thr Ser Glu Leu Leu Tyr Arg Thr Pro Pro Gly Ser Pro Gln Leu
            180                 185                 190         
Ala Met Leu Lys Ser Ser Lys Met Lys His Pro Ile Ile Pro Ile His
        195                 200                 205             
Asn Ser Leu Glu Arg Gln Met Glu Leu Ser Thr Cys Glu Asn Gly Ser
    210                 215                 220                 
Leu Asn Met Glu Ile Asn Gly Glu Glu Glu Ile Leu Met Lys Asn Lys
225                 230                 235                 240 
Asn Ser Leu Tyr Leu Lys Ser Ala Glu Ile Asp Cys Ser Ile Ser Ser
                245                 250                 255     
Glu Glu Asn Thr Asp Asp Asn Ile Thr Val Gln Gly Glu Ile Arg Lys
            260                 265                 270         
Glu Asp Gly Met Glu Asn Leu Lys Asn His Asp Asn Asn Leu Ser Gln
        275                 280                 285             
Ser Gly Ser Asp Ser Ser Cys Ser Pro Glu Cys Leu Trp Glu Glu Gly
    290                 295                 300                 
Lys Glu Val Ile Pro Thr Phe Phe Ser Thr Met Asn Thr Ser Phe Ser
305                 310                 315                 320 
Asp Ile Glu Leu Leu Glu Asp Ser Gly Ile Pro Thr Glu Ala Phe Leu
                325                 330                 335     
Ala Ser Cys Cys Ala Val Val Pro Val Leu Asp Lys Leu Gly Pro Thr
            340                 345                 350         
Val Phe Ala Pro Val Lys Met Asp Leu Val Glu Asn Ile Lys Lys Val
        355                 360                 365             
Asn Gln Lys Tyr Ile Thr Asn Lys Glu Glu Phe Thr Thr Leu Gln Lys
    370                 375                 380                 
Ile Val Leu His Glu Val Glu Ala Asp Val Ala Gln Val Arg Asn Ser
385                 390                 395                 400 
Ala Thr Glu Ala Leu Leu Trp Leu Lys Arg Gly Leu Lys Phe Leu Lys
                405                 410                 415     
Gly Phe Leu Thr Glu Val Lys Asn Gly Glu Lys Asp Ile Gln Thr Ala
            420                 425                 430         
Leu Asn Asn Ala Tyr Gly Lys Thr Leu Arg Gln His His Gly Trp Val
        435                 440                 445             
Val Arg Gly Val Phe Ala Leu Ala Leu Arg Ala Thr Pro Ser Tyr Glu
    450                 455                 460                 
Asp Phe Val Ala Ala Leu Thr Val Lys Glu Gly Asp His Arg Lys Glu
465                 470                 475                 480 
Ala Phe Ser Ile Gly Met Gln Arg Asp Leu Ser Leu Tyr Leu Pro Ala
                485                 490                 495     
Met Lys Lys Gln Met Ala Ile Leu Asp Ala Leu
            500                 505         


<210> 6311
<211> 767
<212> PRT
<213> Homo sapiens

<400> 6311
Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala Asn Ile Arg Asn
 1               5                  10                  15      
Met Ser Val Ile Ala His Val Asp His Gly Lys Ser Thr Leu Thr Asp
            20                  25                  30          
Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala Arg Ala Gly Glu
        35                  40                  45              
Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln Glu Arg Cys Ile Thr
    50                  55                  60                  
Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu Ser Glu Asn Asp
65                  70                  75                  80  
Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala Gly Phe Leu Ile Asn
                85                  90                  95      
Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser Glu Val Thr Ala
            100                 105                 110         
Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val Asp Cys Val Ser
        115                 120                 125             
Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln Ala Ile Ala Glu
    130                 135                 140                 
Arg Ile Lys Pro Val Leu Met Met Asn Lys Met Asp Arg Ala Leu Leu
145                 150                 155                 160 
Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln Thr Phe Gln Arg Ile
                165                 170                 175     
Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr Gly Glu Gly Glu Ser
            180                 185                 190         
Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val Leu Gly Thr Val Gly
        195                 200                 205             
Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr Leu Lys Gln Phe Ala
    210                 215                 220                 
Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly Glu Gly Gln Cys Leu
225                 230                 235                 240 
Met His Arg Ser Leu Pro Pro Gln Ala Val Met Arg Arg Trp Leu Pro
                245                 250                 255     
Ala Gly Asp Ala Leu Leu Gln Met Ile Thr Ile His Leu Pro Ser Pro
            260                 265                 270         
Val Thr Ala Gln Lys Tyr Arg Cys Glu Leu Leu Tyr Glu Gly Pro Pro
        275                 280                 285             
Asp Asp Glu Ala Ala Met Gly Ile Lys Ser Cys Asp Pro Lys Gly Pro
    290                 295                 300                 
Leu Met Met Tyr Ile Ser Lys Met Val Pro Thr Ser Asp Lys Gly Arg
305                 310                 315                 320 
Phe Tyr Ala Phe Gly Arg Val Phe Ser Gly Leu Val Ser Thr Gly Leu
                325                 330                 335     
Lys Val Arg Ile Met Gly Pro Asn Tyr Thr Pro Gly Lys Lys Glu Asp
            340                 345                 350         
Leu Tyr Leu Lys Pro Ile Gln Arg Thr Ile Leu Met Met Gly Arg Tyr
        355                 360                 365             
Val Glu Pro Ile Glu Asp Val Pro Cys Gly Asn Ile Val Gly Leu Val
    370                 375                 380                 
Gly Val Asp Gln Phe Leu Val Lys Thr Gly Thr Ile Thr Thr Phe Glu
385                 390                 395                 400 
His Ala His Asn Met Arg Val Met Lys Phe Ser Val Ser Pro Val Val
                405                 410                 415     
Arg Val Ala Val Glu Ala Lys Asn Pro Ala Asp Leu Pro Lys Leu Val
            420                 425                 430         
Glu Gly Leu Lys Arg Leu Ala Lys Ser Asp Pro Met Val Gln Cys Ile
        435                 440                 445             
Ile Glu Glu Ser Gly Glu His Ile Ile Ala Gly Ala Gly Glu Leu His
    450                 455                 460                 
Leu Glu Ile Cys Leu Lys Asp Leu Glu Glu Asp His Ala Cys Ile Pro
465                 470                 475                 480 
Ile Lys Lys Ser Asp Pro Val Val Ser Tyr Arg Glu Thr Val Ser Glu
                485                 490                 495     
Glu Ser Asn Val Leu Cys Leu Ser Lys Ser Pro Asn Lys His Asn Arg
            500                 505                 510         
Leu Tyr Met Lys Ala Arg Pro Phe Pro Asp Gly Leu Ala Glu Asp Ile
        515                 520                 525             
Asp Lys Gly Glu Val Ser Ala Arg Gln Glu Leu Lys Gln Arg Ala Arg
    530                 535                 540                 
Tyr Leu Ala Glu Lys Tyr Glu Trp Asp Val Ala Glu Ala Arg Lys Ile
545                 550                 555                 560 
Trp Cys Phe Gly Pro Asp Gly Thr Gly Pro Asn Ile Leu Thr Asp Ile
                565                 570                 575     
Thr Lys Gly Val Gln Tyr Leu Asn Glu Ile Lys Asp Ser Val Val Ala
            580                 585                 590         
Gly Phe Gln Trp Ala Thr Lys Glu Gly Ala Leu Cys Glu Glu Asn Met
        595                 600                 605             
Arg Gly Val Arg Phe Asp Val His Asp Val Thr Leu His Ala Asp Ala
    610                 615                 620                 
Ile His Arg Gly Gly Gly Gln Ile Ile Pro Thr Ala Arg Arg Cys Leu
625                 630                 635                 640 
Tyr Ala Ser Val Leu Thr Ala Gln Pro Arg Leu Met Glu Pro Ile Tyr
                645                 650                 655     
Leu Val Glu Ile Gln Cys Pro Glu Gln Val Val Gly Gly Ile Tyr Gly
            660                 665                 670         
Val Leu Asn Arg Lys Arg Gly His Val Phe Glu Glu Ser Gln Val Ala
        675                 680                 685             
Gly Thr Pro Met Phe Val Val Lys Ala Tyr Leu Pro Val Asn Glu Ser
    690                 695                 700                 
Phe Gly Phe Thr Ala Asp Leu Arg Ser Asn Thr Gly Gly Gln Ala Phe
705                 710                 715                 720 
Pro Gln Cys Val Phe Asp His Trp Gln Ile Leu Pro Gly Asp Pro Phe
                725                 730                 735     
Asp Asn Ser Ser Arg Pro Ser Gln Val Val Ala Glu Thr Arg Lys Arg
            740                 745                 750         
Lys Gly Leu Lys Glu Gly Ile Pro Ala Leu Asp Asn Phe Leu Asp
        755                 760                 765         


<210> 6312
<211> 882
<212> PRT
<213> Homo sapiens

<400> 6312
Ser Ser Pro Pro Ser Ser Ala Arg Leu Ala Ser Phe Gly Ser Thr Trp
 1               5                  10                  15      
Glu Asn Pro Pro Pro Ser Ala Thr Met Val Asn Phe Thr Val Asp Gln
            20                  25                  30          
Ile Arg Ala Ile Met Asp Lys Lys Ala Asn Ile Arg Asn Met Ser Val
        35                  40                  45              
Ile Ala His Val Asp His Gly Lys Ser Thr Leu Thr Asp Ser Leu Val
    50                  55                  60                  
Cys Lys Ala Gly Ile Ile Ala Ser Ala Arg Ala Gly Glu Thr Arg Phe
65                  70                  75                  80  
Thr Asp Thr Arg Lys Asp Glu Gln Glu Arg Cys Ile Thr Ile Lys Ser
                85                  90                  95      
Thr Ala Ile Ser Leu Phe Tyr Glu Leu Ser Glu Asn Asp Leu Asn Phe
            100                 105                 110         
Ile Lys Gln Ser Lys Asp Gly Ala Gly Phe Leu Ile Asn Leu Ile Asp
        115                 120                 125             
Ser Pro Gly His Val Asp Phe Ser Ser Glu Val Thr Ala Ala Leu Arg
    130                 135                 140                 
Val Thr Asp Gly Ala Leu Val Val Val Asp Cys Val Ser Gly Val Cys
145                 150                 155                 160 
Val Gln Thr Glu Thr Val Leu Arg Gln Ala Ile Ala Glu Arg Ile Lys
                165                 170                 175     
Pro Val Leu Met Met Asn Lys Met Asp Arg Ala Leu Leu Glu Leu Gln
            180                 185                 190         
Leu Glu Pro Glu Glu Leu Tyr Gln Thr Phe Gln Arg Ile Val Glu Asn
        195                 200                 205             
Val Asn Val Ile Ile Ser Thr Tyr Gly Glu Gly Glu Ser Gly Pro Met
    210                 215                 220                 
Gly Asn Ile Met Ile Asp Pro Val Leu Gly Thr Val Gly Phe Gly Ser
225                 230                 235                 240 
Gly Leu His Gly Trp Ala Phe Thr Leu Lys Gln Phe Ala Glu Met Tyr
                245                 250                 255     
Val Ala Lys Phe Ala Ala Lys Gly Glu Gly Gln Leu Gly Pro Ala Glu
            260                 265                 270         
Arg Ala Lys Lys Val Glu Asp Met Met Lys Lys Leu Trp Gly Asp Arg
        275                 280                 285             
Tyr Phe Asp Pro Ala Asn Gly Lys Phe Ser Lys Ser Ala Thr Ser Pro
    290                 295                 300                 
Glu Gly Lys Lys Leu Pro Arg Thr Phe Cys Gln Leu Ile Leu Asp Pro
305                 310                 315                 320 
Ile Phe Lys Val Phe Asp Ala Ile Met Asn Phe Lys Lys Glu Glu Thr
                325                 330                 335     
Ala Lys Leu Ile Glu Lys Leu Asp Ile Lys Leu Asp Ser Glu Asp Lys
            340                 345                 350         
Asp Lys Glu Gly Lys Pro Leu Leu Lys Ala Val Met Arg Arg Trp Leu
        355                 360                 365             
Pro Ala Gly Asp Ala Leu Leu Gln Met Ile Thr Ile His Leu Pro Ser
    370                 375                 380                 
Pro Val Thr Ala Gln Lys Tyr Arg Cys Glu Leu Leu Tyr Glu Gly Pro
385                 390                 395                 400 
Pro Asp Asp Glu Ala Ala Met Gly Ile Lys Ser Cys Asp Pro Lys Gly
                405                 410                 415     
Pro Leu Met Met Tyr Ile Ser Lys Met Val Pro Thr Ser Asp Lys Gly
            420                 425                 430         
Arg Phe Tyr Ala Phe Gly Arg Val Phe Ser Gly Leu Val Ser Thr Gly
        435                 440                 445             
Leu Lys Val Arg Ile Met Gly Pro Asn Tyr Thr Pro Gly Lys Lys Glu
    450                 455                 460                 
Asp Leu Tyr Leu Lys Pro Ile Gln Arg Thr Ile Leu Met Met Gly Arg
465                 470                 475                 480 
Tyr Val Glu Pro Ile Glu Asp Val Pro Cys Gly Asn Ile Val Gly Leu
                485                 490                 495     
Val Gly Val Asp Gln Phe Leu Val Lys Thr Gly Thr Ile Thr Thr Phe
            500                 505                 510         
Glu His Ala His Asn Met Arg Val Met Lys Phe Ser Val Ser Pro Val
        515                 520                 525             
Val Arg Val Ala Val Glu Ala Lys Asn Pro Ala Asp Leu Pro Lys Leu
    530                 535                 540                 
Val Glu Gly Leu Lys Arg Leu Ala Lys Ser Asp Pro Met Val Gln Cys
545                 550                 555                 560 
Ile Ile Glu Glu Ser Gly Glu His Ile Ile Ala Gly Ala Gly Glu Leu
                565                 570                 575     
His Leu Glu Ile Cys Leu Lys Asp Leu Glu Glu Asp His Ala Cys Ile
            580                 585                 590         
Pro Ile Lys Lys Ser Asp Pro Val Val Ser Tyr Arg Glu Thr Val Ser
        595                 600                 605             
Glu Glu Ser Asn Val Leu Cys Leu Ser Lys Ser Pro Asn Lys His Asn
    610                 615                 620                 
Arg Leu Tyr Met Lys Ala Arg Pro Phe Pro Asp Gly Leu Ala Glu Asp
625                 630                 635                 640 
Ile Asp Lys Gly Glu Val Ser Ala Arg Gln Glu Leu Lys Gln Arg Ala
                645                 650                 655     
Arg Tyr Leu Ala Glu Lys Tyr Glu Trp Asp Val Ala Glu Ala Arg Lys
            660                 665                 670         
Ile Trp Cys Phe Gly Pro Asp Gly Thr Gly Pro Asn Ile Leu Thr Asp
        675                 680                 685             
Ile Thr Lys Gly Val Gln Tyr Leu Asn Glu Ile Lys Asp Ser Val Val
    690                 695                 700                 
Ala Gly Phe Gln Trp Ala Thr Lys Glu Gly Ala Leu Cys Glu Glu Asn
705                 710                 715                 720 
Met Arg Gly Val Arg Phe Asp Val His Asp Val Thr Leu His Ala Asp
                725                 730                 735     
Ala Ile His Arg Gly Gly Gly Gln Ile Ile Pro Thr Ala Arg Arg Cys
            740                 745                 750         
Leu Tyr Ala Ser Val Leu Thr Ala Gln Pro Arg Leu Met Glu Pro Ile
        755                 760                 765             
Tyr Leu Val Glu Ile Gln Cys Pro Glu Gln Val Val Gly Gly Ile Tyr
    770                 775                 780                 
Gly Val Leu Asn Arg Lys Arg Gly His Val Phe Glu Glu Ser Gln Val
785                 790                 795                 800 
Ala Gly Thr Pro Met Phe Val Val Lys Ala Tyr Leu Pro Val Asn Glu
                805                 810                 815     
Ser Phe Gly Phe Thr Ala Asp Leu Arg Ser Asn Thr Gly Gly Gln Ala
            820                 825                 830         
Phe Pro Gln Cys Val Phe Asp His Trp Gln Ile Leu Pro Gly Asp Pro
        835                 840                 845             
Phe Asp Asn Ser Ser Arg Pro Ser Gln Val Val Ala Glu Thr Arg Lys
    850                 855                 860                 
Arg Lys Gly Leu Lys Glu Gly Ile Pro Ala Leu Asp Asn Phe Leu Asp
865                 870                 875                 880 
Lys Leu
        


<210> 6313
<211> 870
<212> PRT
<213> Homo sapiens

<400> 6313
Met Ala Ser Ala Ser Ser Ser Arg Ala Gly Val Ala Leu Pro Phe Glu
 1               5                  10                  15      
Lys Ser Gln Leu Thr Leu Lys Val Val Ser Ala Lys Pro Lys Val His
            20                  25                  30          
Asn Arg Gln Pro Arg Ile Asn Ser Tyr Val Glu Val Ala Val Asp Gly
        35                  40                  45              
Leu Pro Ser Glu Thr Lys Lys Thr Gly Lys Arg Ile Gly Ser Ser Glu
    50                  55                  60                  
Leu Leu Trp Asn Glu Ile Ile Ile Leu Asn Val Thr Ala Gln Ser His
65                  70                  75                  80  
Leu Asp Leu Lys Val Trp Ser Cys His Thr Leu Arg Asn Glu Leu Leu
                85                  90                  95      
Gly Thr Ala Ser Val Asn Leu Ser Asn Val Leu Lys Asn Asn Gly Gly
            100                 105                 110         
Lys Met Glu Asn Met Gln Leu Thr Leu Asn Leu Gln Thr Glu Asn Lys
        115                 120                 125             
Gly Ser Val Val Ser Gly Gly Glu Leu Thr Ile Phe Leu Asp Gly Pro
    130                 135                 140                 
Thr Val Asp Leu Gly Asn Val Pro Asn Gly Ser Ala Leu Thr Asp Gly
145                 150                 155                 160 
Ser Gln Leu Pro Ser Arg Asp Ser Ser Gly Thr Ala Val Ala Pro Glu
                165                 170                 175     
Asn Arg His Gln Pro Pro Ser Thr Asn Cys Phe Gly Gly Arg Ser Arg
            180                 185                 190         
Thr His Arg His Ser Gly Ala Ser Ala Arg Thr Thr Pro Ala Thr Gly
        195                 200                 205             
Glu Gln Ser Pro Gly Ala Arg Ser Arg His Arg Gln Pro Val Lys Asn
    210                 215                 220                 
Ser Gly His Ser Gly Leu Ala Asn Gly Thr Val Asn Asp Glu Pro Thr
225                 230                 235                 240 
Thr Ala Thr Asp Pro Glu Glu Pro Ser Val Val Gly Val Thr Ser Pro
                245                 250                 255     
Pro Ala Ala Pro Leu Ser Val Thr Pro Asn Pro Asn Thr Thr Ser Leu
            260                 265                 270         
Pro Ala Pro Ala Thr Pro Ala Glu Gly Glu Glu Pro Ser Thr Ser Gly
        275                 280                 285             
Thr Gln Gln Leu Pro Ala Ala Ala Gln Ala Pro Asp Ala Leu Pro Ala
    290                 295                 300                 
Gly Trp Glu Gln Arg Glu Leu Pro Asn Gly Arg Val Tyr Tyr Val Asp
305                 310                 315                 320 
His Asn Thr Lys Thr Thr Thr Trp Glu Arg Pro Leu Pro Pro Gly Trp
                325                 330                 335     
Glu Lys Arg Thr Asp Pro Arg Gly Arg Phe Tyr Tyr Val Asp His Asn
            340                 345                 350         
Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Glu Tyr Val Arg Asn
        355                 360                 365             
Tyr Glu Gln Trp Gln Ser Gln Arg Asn Gln Leu Gln Gly Ala Met Gln
    370                 375                 380                 
His Phe Ser Gln Arg Phe Leu Tyr Gln Ser Ser Ser Ala Ser Thr Asp
385                 390                 395                 400 
His Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Gln Asp
                405                 410                 415     
Asn Gly Arg Val Tyr Tyr Val Asn His Asn Thr Arg Thr Thr Gln Trp
            420                 425                 430         
Glu Asp Pro Arg Thr Gln Gly Met Ile Gln Glu Pro Ala Leu Pro Pro
        435                 440                 445             
Gly Trp Glu Met Lys Tyr Thr Ser Glu Gly Val Arg Tyr Phe Val Asp
    450                 455                 460                 
His Asn Thr Arg Thr Thr Thr Phe Lys Asp Pro Arg Pro Gly Phe Glu
465                 470                 475                 480 
Ser Gly Thr Lys Gln Gly Ser Pro Gly Ala Tyr Asp Arg Ser Phe Arg
                485                 490                 495     
Trp Lys Tyr His Gln Phe Arg Phe Leu Cys His Ser Asn Ala Leu Pro
            500                 505                 510         
Ser His Val Lys Ile Ser Val Ser Arg Gln Thr Leu Phe Glu Asp Ser
        515                 520                 525             
Phe Gln Gln Ile Met Asn Met Lys Pro Tyr Asp Leu Arg Arg Arg Leu
    530                 535                 540                 
Tyr Ile Ile Met Arg Gly Glu Glu Gly Leu Asp Tyr Gly Gly Ile Ala
545                 550                 555                 560 
Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met Tyr
                565                 570                 575     
Cys Leu Phe Glu Tyr Ala Gly Lys Asn Asn Tyr Cys Leu Gln Ile Asn
            580                 585                 590         
Pro Ala Ser Ser Ile Asn Pro Asp His Leu Thr Tyr Phe Arg Phe Ile
        595                 600                 605             
Gly Arg Phe Ile Ala Met Ala Leu Tyr His Gly Lys Phe Ile Asp Thr
    610                 615                 620                 
Gly Phe Thr Leu Pro Phe Tyr Lys Arg Met Leu Asn Lys Arg Pro Thr
625                 630                 635                 640 
Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Ile Val
                645                 650                 655     
Trp Ile Lys Glu Asn Asn Leu Glu Glu Cys Gly Leu Glu Leu Tyr Phe
            660                 665                 670         
Ile Gln Asp Met Glu Ile Leu Gly Lys Val Thr Thr His Glu Leu Lys
        675                 680                 685             
Glu Gly Gly Glu Ser Ile Arg Val Thr Glu Glu Asn Lys Glu Glu Tyr
    690                 695                 700                 
Ile Met Leu Leu Thr Asp Trp Arg Phe Thr Arg Gly Val Glu Glu Gln
705                 710                 715                 720 
Thr Lys Ala Phe Leu Asp Gly Phe Asn Glu Val Ala Pro Leu Glu Trp
                725                 730                 735     
Leu Arg Tyr Phe Asp Glu Lys Glu Leu Glu Leu Met Leu Cys Gly Met
            740                 745                 750         
Gln Glu Ile Asp Met Ser Asp Trp Gln Lys Ser Thr Ile Tyr Arg His
        755                 760                 765             
Tyr Thr Lys Asn Ser Lys Gln Ile Gln Trp Phe Trp Gln Val Val Lys
    770                 775                 780                 
Glu Met Asp Asn Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly
785                 790                 795                 800 
Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Glu Leu Ile Gly Ser Asn
                805                 810                 815     
Gly Pro Gln Lys Phe Cys Ile Asp Lys Val Gly Lys Glu Thr Trp Leu
            820                 825                 830         
Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Lys
        835                 840                 845             
Ser Tyr Glu Gln Leu Arg Glu Lys Leu Leu Tyr Ala Ile Glu Glu Thr
    850                 855                 860                 
Glu Gly Phe Gly Gln Glu
865                 870 


<210> 6314
<211> 593
<212> PRT
<213> Homo sapiens

<400> 6314
Met Ala Pro Pro Val Ala Glu Arg Gly Leu Lys Ser Val Val Trp Gln
 1               5                  10                  15      
Lys Ile Lys Ala Thr Val Phe Asp Asp Cys Lys Lys Glu Gly Glu Trp
            20                  25                  30          
Lys Ile Met Leu Leu Asp Glu Phe Thr Thr Lys Leu Leu Ala Ser Cys
        35                  40                  45              
Cys Lys Met Thr Asp Leu Leu Glu Glu Gly Ile Thr Val Val Glu Asn
    50                  55                  60                  
Ile Tyr Lys Asn Arg Glu Pro Val Arg Gln Met Lys Ala Leu Tyr Phe
65                  70                  75                  80  
Ile Thr Pro Thr Ser Lys Ser Val Asp Cys Phe Leu His Asp Phe Ala
                85                  90                  95      
Ser Lys Ser Glu Asn Lys Tyr Lys Ala Ala Tyr Ile Tyr Phe Thr Asp
            100                 105                 110         
Phe Cys Pro Asp Asn Leu Phe Asn Lys Ile Lys Ala Ser Cys Ser Lys
        115                 120                 125             
Ser Ile Arg Arg Cys Lys Glu Ile Asn Ile Ser Phe Ile Pro His Glu
    130                 135                 140                 
Ser Gln Val Tyr Thr Leu Asp Val Pro Asp Ala Phe Tyr Tyr Cys Tyr
145                 150                 155                 160 
Ser Pro Asp Pro Gly Asn Ala Lys Gly Lys Asp Ala Ile Met Glu Thr
                165                 170                 175     
Met Ala Asp Gln Ile Val Thr Val Cys Ala Thr Leu Asp Glu Asn Pro
            180                 185                 190         
Gly Val Arg Tyr Lys Ser Lys Pro Leu Asp Asn Ala Ser Lys Leu Ala
        195                 200                 205             
Gln Leu Val Glu Lys Lys Leu Glu Asp Tyr Tyr Lys Ile Asp Glu Lys
    210                 215                 220                 
Ser Leu Ile Lys Gly Lys Thr His Ser Gln Leu Leu Ile Ile Asp Arg
225                 230                 235                 240 
Gly Phe Asp Pro Val Ser Thr Val Leu His Glu Leu Thr Phe Gln Ala
                245                 250                 255     
Met Ala Tyr Asp Leu Leu Pro Ile Glu Asn Asp Thr Tyr Lys Gln Tyr
            260                 265                 270         
Lys Thr Asp Gly Lys Glu Lys Glu Ala Ile Leu Glu Glu Glu Asp Asp
        275                 280                 285             
Leu Trp Val Arg Ile Arg His Arg His Ile Ala Val Val Leu Glu Glu
    290                 295                 300                 
Ile Pro Lys Leu Met Lys Glu Ile Ser Ser Thr Lys Lys Ala Thr Glu
305                 310                 315                 320 
Gly Lys Thr Ser Leu Ser Ala Leu Thr Gln Leu Met Lys Lys Met Pro
                325                 330                 335     
His Phe Arg Lys Gln Ile Thr Lys Gln Val Val His Leu Asn Leu Ala
            340                 345                 350         
Glu Asp Cys Met Asn Lys Phe Lys Leu Asn Ile Glu Lys Leu Cys Lys
        355                 360                 365             
Thr Glu Gln Asp Leu Ala Leu Gly Thr Asp Ala Glu Gly Gln Lys Val
    370                 375                 380                 
Lys Asp Ser Met Arg Val Leu Leu Pro Val Leu Leu Asn Lys Asn His
385                 390                 395                 400 
Asp Asn Cys Asp Lys Ile Arg Ala Ile Leu Leu Tyr Ile Phe Ser Ile
                405                 410                 415     
Asn Gly Thr Thr Glu Glu Asn Leu Asp Arg Leu Ile Gln Asn Val Lys
            420                 425                 430         
Ile Glu Asn Glu Ser Asp Met Ile Arg Asn Trp Ser Tyr Leu Gly Val
        435                 440                 445             
Pro Ile Val Pro Gln Ser Gln Gln Gly Lys Pro Leu Arg Lys Asp Arg
    450                 455                 460                 
Ser Ala Glu Glu Thr Phe Gln Leu Ser Arg Trp Thr Pro Phe Ile Lys
465                 470                 475                 480 
Asp Ile Met Glu Asp Ala Ile Asp Asn Arg Leu Asp Ser Lys Glu Trp
                485                 490                 495     
Pro Tyr Cys Ser Gln Cys Pro Ala Val Trp Asn Gly Ser Gly Ala Val
            500                 505                 510         
Ser Ala Arg Gln Lys Pro Arg Ala Asn Tyr Leu Glu Asp Arg Lys Asn
        515                 520                 525             
Gly Ser Lys Leu Ile Val Phe Val Ile Gly Gly Ile Thr Tyr Ser Glu
    530                 535                 540                 
Val Arg Cys Ala Tyr Glu Val Ser Gln Ala His Lys Ser Cys Glu Val
545                 550                 555                 560 
Ile Ile Gly Ser Thr His Val Leu Thr Pro Lys Lys Leu Leu Asp Asp
                565                 570                 575     
Ile Lys Met Leu Asn Lys Pro Lys Asp Lys Val Ser Leu Ile Lys Asp
            580                 585                 590         
Glu
    


<210> 6315
<211> 1861
<212> PRT
<213> Homo sapiens

<400> 6315
Met Met Asp Leu Val Leu Glu Glu Asp Val Thr Val Pro Gly Thr Leu
 1               5                  10                  15      
Ser Gly Cys Ser Gly Leu Val Pro Ser Val Pro Asp Asp Leu Asp Gly
            20                  25                  30          
Ile Asn Pro Asn Ala Gly Leu Gly Asn Gly Val Leu Pro Asn Val Ser
        35                  40                  45              
Glu Glu Thr Val Ser Pro Thr Arg Ala Arg Asn Met Lys Asp Phe Glu
    50                  55                  60                  
Asn Gln Ile Thr Glu Leu Lys Lys Glu Asn Phe Asn Leu Lys Leu Arg
65                  70                  75                  80  
Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln Glu Phe His Gly Pro Thr
                85                  90                  95      
Glu His Ile Tyr Lys Thr Asn Ile Glu Leu Lys Val Glu Val Glu Ser
            100                 105                 110         
Leu Lys Arg Glu Leu Gln Glu Arg Glu Gln Leu Leu Ile Lys Ala Ser
        115                 120                 125             
Lys Ala Val Glu Ser Leu Ala Glu Ala Gly Gly Ser Glu Ile Gln Arg
    130                 135                 140                 
Val Lys Glu Asp Ala Arg Lys Lys Val Gln Gln Val Glu Asp Leu Leu
145                 150                 155                 160 
Thr Lys Arg Ile Leu Leu Leu Glu Lys Asp Val Thr Ala Ala Gln Ala
                165                 170                 175     
Glu Leu Glu Lys Ala Phe Ala Gly Thr Glu Thr Glu Lys Ala Leu Arg
            180                 185                 190         
Leu Arg Leu Glu Ser Lys Leu Ser Glu Met Lys Lys Met His Glu Gly
        195                 200                 205             
Asp Leu Ala Met Ala Leu Val Leu Asp Glu Lys Asp Arg Leu Ile Glu
    210                 215                 220                 
Glu Leu Lys Leu Ser Leu Lys Ser Lys Glu Ala Leu Ile Gln Cys Leu
225                 230                 235                 240 
Lys Glu Glu Lys Ser Gln Met Ala Cys Pro Asp Glu Asn Val Ser Ser
                245                 250                 255     
Gly Glu Leu Arg Gly Leu Cys Ala Ala Pro Arg Glu Glu Lys Glu Arg
            260                 265                 270         
Glu Thr Glu Ala Ala Gln Met Glu His Gln Lys Glu Arg Asn Ser Phe
        275                 280                 285             
Glu Glu Arg Ile Gln Ala Leu Glu Glu Asp Leu Arg Glu Lys Glu Arg
    290                 295                 300                 
Glu Ile Ala Thr Glu Lys Lys Asn Ser Leu Lys Arg Asp Lys Ala Ile
305                 310                 315                 320 
Gln Gly Leu Thr Met Ala Leu Lys Ser Lys Glu Lys Lys Val Glu Glu
                325                 330                 335     
Leu Asn Ser Glu Ile Glu Lys Leu Ser Ala Ala Phe Ala Lys Ala Arg
            340                 345                 350         
Glu Ala Leu Gln Lys Ala Gln Thr Gln Glu Phe Gln Gly Ser Glu Asp
        355                 360                 365             
Tyr Glu Thr Ala Leu Ser Gly Lys Glu Ala Leu Ser Ala Ala Leu Arg
    370                 375                 380                 
Ser Gln Asn Leu Thr Lys Ser Thr Glu Asn His Arg Leu Arg Arg Ser
385                 390                 395                 400 
Ile Lys Lys Ile Thr Gln Glu Leu Ser Asp Leu Gln Gln Glu Arg Glu
                405                 410                 415     
Arg Leu Glu Lys Asp Leu Glu Glu Ala His Arg Glu Lys Ser Lys Gly
            420                 425                 430         
Asp Cys Thr Ile Arg Asp Leu Arg Asn Glu Val Glu Lys Leu Arg Asn
        435                 440                 445             
Glu Val Asn Glu Arg Glu Lys Ala Met Glu Asn Arg Tyr Lys Ser Leu
    450                 455                 460                 
Leu Ser Glu Ser Asn Lys Lys Leu His Asn Gln Glu Gln Val Ile Lys
465                 470                 475                 480 
His Leu Thr Glu Ser Thr Asn Gln Lys Asp Val Leu Leu Gln Lys Phe
                485                 490                 495     
Asn Glu Lys Asp Leu Glu Val Ile Gln Gln Asn Cys Tyr Leu Met Ala
            500                 505                 510         
Ala Glu Asp Leu Glu Leu Arg Ser Glu Gly Leu Ile Thr Glu Lys Cys
        515                 520                 525             
Ser Ser Gln Gln Pro Pro Gly Ser Lys Thr Ile Phe Ser Lys Glu Lys
    530                 535                 540                 
Lys Gln Ser Ser Asp Tyr Glu Glu Leu Ile Gln Val Leu Lys Lys Glu
545                 550                 555                 560 
Gln Asp Ile Tyr Thr His Leu Val Lys Ser Leu Gln Glu Ser Asp Ser
                565                 570                 575     
Ile Asn Asn Leu Gln Ala Glu Leu Asn Lys Ile Phe Ala Leu Arg Lys
            580                 585                 590         
Gln Leu Glu Gln Asp Val Leu Ser Tyr Gln Asn Leu Arg Lys Thr Leu
        595                 600                 605             
Glu Glu Gln Ile Ser Glu Ile Arg Arg Arg Glu Glu Glu Ser Phe Ser
    610                 615                 620                 
Leu Tyr Ser Asp Gln Thr Phe Tyr Leu Ser Ile Cys Leu Glu Glu Asn
625                 630                 635                 640 
Asn Arg Phe Gln Val Glu His Phe Ser Gln Glu Glu Leu Lys Lys Lys
                645                 650                 655     
Val Ser Asp Leu Ile Gln Leu Val Lys Glu Leu Tyr Thr Asp Asn Gln
            660                 665                 670         
His Leu Lys Lys Thr Ile Phe Asp Leu Ser Cys Met Gly Phe Gln Gly
        675                 680                 685             
Asn Gly Phe Pro Asp Arg Leu Ala Ser Thr Glu Gln Thr Glu Ile Met
    690                 695                 700                 
Lys Asp Leu Ser Lys Gly Gly Cys Lys Asn Gly Tyr Leu Arg His Thr
705                 710                 715                 720 
Glu Ser Lys Ile Ser Asp Cys Asp Gly Ala His Ala Pro Gly Cys Leu
                725                 730                 735     
Glu Glu Gly Ala Phe Ile Asn Leu Leu Ala Pro Leu Phe Asn Glu Lys
            740                 745                 750         
Ala Thr Leu Leu Leu Glu Ser Arg Pro Asp Leu Leu Lys Val Val Arg
        755                 760                 765             
Glu Leu Leu Leu Gly Gln Leu Phe Leu Thr Glu Gln Glu Val Ser Gly
    770                 775                 780                 
Glu His Leu Asp Gly Lys Thr Glu Lys Thr Pro Lys Gln Lys Gly Glu
785                 790                 795                 800 
Leu Val His Phe Val Gln Thr Asn Ser Phe Ser Lys Pro His Asp Glu
                805                 810                 815     
Leu Lys Leu Ser Cys Glu Ala Gln Leu Val Lys Ala Gly Glu Val Pro
            820                 825                 830         
Lys Val Gly Leu Lys Asp Ala Ser Val Gln Thr Val Ala Thr Glu Gly
        835                 840                 845             
Asp Leu Leu Arg Phe Lys His Glu Ala Thr Arg Glu Ala Trp Glu Glu
    850                 855                 860                 
Lys Pro Ile Asn Thr Ala Leu Ser Ala Glu His Arg Pro Glu Asn Leu
865                 870                 875                 880 
His Gly Val Pro Gly Trp Gln Ala Ala Leu Leu Ser Leu Pro Gly Ile
                885                 890                 895     
Thr Asn Arg Glu Ala Lys Lys Ser Arg Leu Pro Ile Leu Ile Lys Pro
            900                 905                 910         
Ser Arg Ser Leu Gly Asn Met Tyr Arg Leu Pro Ala Thr Gln Glu Val
        915                 920                 925             
Val Thr Gln Leu Gln Ser Gln Ile Leu Glu Leu Gln Gly Glu Leu Lys
    930                 935                 940                 
Glu Phe Lys Thr Cys Asn Lys Gln Leu His Gln Lys Leu Ile Leu Ala
945                 950                 955                 960 
Glu Ala Val Met Glu Gly Arg Pro Thr Pro Asp Lys Thr Leu Leu Asn
                965                 970                 975     
Ala Gln Pro Pro Val Gly Ala Ala Tyr Gln Asp Ser Pro Gly Glu Gln
            980                 985                 990         
Lys Gly Ile Lys Thr Thr Ser Ser Val Trp Arg Asp Lys Glu Met Asp
        995                 1000                1005            
Ser Asp Gln Gln Arg Ser Tyr Glu Ile Asp Ser Glu Ile Cys Pro Pro
    1010                1015                1020                
Asp Asp Leu Ala Ser Leu Pro Ser Cys Lys Glu Asn Pro Glu Asp Val
1025                1030                1035                1040
Leu Ser Pro Thr Ser Val Ala Thr Tyr Leu Ser Ser Lys Ser Gln Pro
                1045                1050                1055    
Ser Ala Lys Val Ser Val Met Gly Thr Asp Gln Ser Glu Ser Ile Asn
            1060                1065                1070        
Thr Ser Asn Glu Thr Glu Tyr Leu Lys Gln Lys Ile His Asp Leu Glu
        1075                1080                1085            
Thr Glu Leu Glu Gly Tyr Gln Asn Phe Ile Phe Gln Leu Gln Lys His
    1090                1095                1100                
Ser Gln Cys Ser Glu Ala Ile Ile Thr Val Leu Cys Gly Thr Glu Gly
1105                1110                1115                1120
Ala Gln Asp Gly Leu Ser Lys Pro Lys Asn Gly Ser Asp Gly Glu Glu
                1125                1130                1135    
Met Thr Phe Ser Ser Leu His Gln Val Arg Tyr Val Lys His Val Lys
            1140                1145                1150        
Ile Leu Gly Pro Leu Ala Pro Glu Met Ile Asp Ser Arg Val Leu Glu
        1155                1160                1165            
Asn Leu Lys Gln Gln Leu Glu Glu Gln Glu Tyr Lys Leu Gln Lys Glu
    1170                1175                1180                
Gln Asn Leu Asn Met Gln Leu Phe Ser Glu Ile His Asn Leu Gln Asn
1185                1190                1195                1200
Lys Phe Arg Asp Leu Ser Pro Pro Arg Tyr Asp Ser Leu Val Gln Ser
                1205                1210                1215    
Gln Ala Arg Glu Leu Ser Leu Gln Arg Gln Gln Ile Lys Asp Gly His
            1220                1225                1230        
Gly Ile Cys Val Ile Ser Arg Gln His Met Asn Thr Met Ile Lys Ala
        1235                1240                1245            
Phe Glu Glu Leu Leu Gln Ala Ser Asp Val Asp Tyr Cys Val Ala Glu
    1250                1255                1260                
Gly Phe Gln Glu Gln Leu Asn Gln Cys Ala Glu Leu Leu Glu Lys Leu
1265                1270                1275                1280
Glu Lys Leu Phe Leu Asn Gly Lys Ser Val Gly Val Glu Met Asn Thr
                1285                1290                1295    
Gln Asn Glu Leu Met Glu Arg Ile Glu Glu Asp Asn Leu Thr Tyr Gln
            1300                1305                1310        
His Leu Leu Pro Glu Ser Pro Glu Pro Ser Ala Ser His Ala Leu Ser
        1315                1320                1325            
Asp Tyr Glu Thr Ser Glu Lys Ser Phe Phe Ser Arg Asp Gln Lys Gln
    1330                1335                1340                
Asp Asn Glu Thr Glu Lys Thr Ser Val Met Val Asn Ser Phe Ser Gln
1345                1350                1355                1360
Asp Leu Leu Met Glu His Ile Gln Glu Ile Arg Thr Leu Arg Lys Arg
                1365                1370                1375    
Leu Glu Glu Ser Ile Lys Thr Asn Glu Lys Leu Arg Lys Gln Leu Glu
            1380                1385                1390        
Arg Gln Gly Ser Glu Phe Val Gln Gly Ser Thr Ser Ile Phe Ala Ser
        1395                1400                1405            
Gly Ser Glu Leu His Ser Ser Leu Thr Ser Glu Ile His Phe Leu Arg
    1410                1415                1420                
Lys Gln Asn Gln Ala Leu Asn Ala Met Leu Ile Lys Gly Ser Arg Asp
1425                1430                1435                1440
Lys Gln Lys Glu Asn Asp Lys Leu Arg Glu Ser Leu Ser Arg Lys Thr
                1445                1450                1455    
Val Ser Leu Glu His Leu Gln Arg Glu Tyr Ala Ser Val Lys Glu Glu
            1460                1465                1470        
Asn Glu Arg Leu Gln Lys Glu Gly Ser Glu Lys Glu Arg His Asn Gln
        1475                1480                1485            
Gln Leu Ile Gln Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Arg Val
    1490                1495                1500                
Gln Glu Glu Leu Lys Leu Arg Gln Gln Leu Leu Ser Gln Asn Asp Lys
1505                1510                1515                1520
Leu Leu Gln Ser Leu Arg Val Glu Leu Lys Ala Tyr Glu Lys Leu Asp
                1525                1530                1535    
Glu Glu His Arg Arg Leu Arg Glu Ala Ser Gly Glu Gly Trp Lys Gly
            1540                1545                1550        
Gln Asp Pro Phe Arg Asp Leu His Ser Leu Leu Met Glu Ile Gln Ala
        1555                1560                1565            
Leu Arg Leu Gln Leu Glu Arg Ser Ile Glu Thr Ser Ser Thr Leu Gln
    1570                1575                1580                
Ser Arg Leu Lys Glu Gln Leu Ala Arg Gly Ala Glu Lys Ala Gln Glu
1585                1590                1595                1600
Gly Ala Leu Thr Leu Ala Val Gln Ala Val Ser Ile Pro Glu Val Pro
                1605                1610                1615    
Leu Gln Pro Asp Lys His Asp Gly Asp Lys Tyr Pro Met Glu Ser Asp
            1620                1625                1630        
Asn Ser Phe Asp Leu Phe Asp Ser Ser Gln Ala Val Thr Pro Lys Ser
        1635                1640                1645            
Val Ser Glu Thr Pro Pro Leu Ser Gly Asn Asp Thr Asp Ser Leu Ser
    1650                1655                1660                
Cys Asp Ser Gly Ser Ser Ala Thr Ser Thr Pro Cys Val Ser Arg Leu
1665                1670                1675                1680
Val Thr Gly His His Leu Trp Ala Ser Lys Asn Gly Arg His Val Leu
                1685                1690                1695    
Gly Leu Ile Glu Asp Tyr Glu Ala Leu Leu Lys Gln Ile Ser Gln Gly
            1700                1705                1710        
Gln Arg Leu Leu Ala Glu Met Asp Ile Gln Thr Gln Glu Ala Pro Ser
        1715                1720                1725            
Ser Thr Ser Gln Glu Leu Gly Thr Lys Gly Pro His Pro Ala Pro Leu
    1730                1735                1740                
Ser Lys Phe Val Ser Ser Val Ser Thr Ala Lys Leu Thr Leu Glu Glu
1745                1750                1755                1760
Ala Tyr Arg Arg Leu Lys Leu Leu Trp Arg Val Ser Leu Pro Glu Asp
                1765                1770                1775    
Gly Gln Cys Pro Leu His Cys Glu Gln Ile Gly Glu Met Lys Ala Glu
            1780                1785                1790        
Val Thr Lys Leu His Lys Lys Leu Phe Glu Gln Glu Lys Lys Leu Gln
        1795                1800                1805            
Asn Thr Met Lys Leu Leu Gln Leu Ser Lys Arg Gln Glu Lys Val Ile
    1810                1815                1820                
Phe Asp Gln Leu Val Val Thr His Lys Ile Leu Arg Lys Ala Arg Gly
1825                1830                1835                1840
Asn Leu Glu Leu Arg Pro Gly Gly Ala His Pro Gly Thr Cys Ser Pro
                1845                1850                1855    
Ser Arg Pro Gly Ser
            1860    


<210> 6316
<211> 1893
<212> PRT
<213> Homo sapiens

<400> 6316
Met Met Asp Leu Val Leu Glu Glu Asp Val Thr Val Pro Gly Thr Leu
 1               5                  10                  15      
Ser Gly Cys Ser Gly Leu Val Pro Ser Val Pro Asp Asp Leu Asp Gly
            20                  25                  30          
Ile Asn Pro Asn Ala Gly Leu Gly Asn Gly Val Leu Pro Asn Val Ser
        35                  40                  45              
Glu Glu Thr Val Ser Pro Thr Arg Ala Arg Asn Met Lys Asp Phe Glu
    50                  55                  60                  
Asn Gln Ile Thr Glu Leu Lys Lys Glu Asn Phe Asn Leu Lys Leu Arg
65                  70                  75                  80  
Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln Glu Phe His Gly Pro Thr
                85                  90                  95      
Glu His Ile Tyr Lys Thr Asn Ile Glu Leu Lys Val Glu Val Glu Ser
            100                 105                 110         
Leu Lys Arg Glu Leu Gln Glu Arg Glu Gln Leu Leu Ile Lys Ala Ser
        115                 120                 125             
Lys Ala Val Glu Ser Leu Ala Glu Ala Gly Gly Ser Glu Ile Gln Arg
    130                 135                 140                 
Val Lys Glu Asp Ala Arg Lys Lys Val Gln Gln Val Glu Asp Leu Leu
145                 150                 155                 160 
Thr Lys Arg Ile Leu Leu Leu Glu Lys Asp Val Thr Ala Ala Gln Ala
                165                 170                 175     
Glu Leu Glu Lys Ala Phe Ala Gly Thr Glu Thr Glu Lys Ala Leu Arg
            180                 185                 190         
Leu Arg Leu Glu Ser Lys Leu Ser Glu Met Lys Lys Met His Glu Gly
        195                 200                 205             
Asp Leu Ala Met Ala Leu Val Leu Asp Glu Lys Asp Arg Leu Ile Glu
    210                 215                 220                 
Glu Leu Lys Leu Ser Leu Lys Ser Lys Glu Ala Leu Ile Gln Cys Leu
225                 230                 235                 240 
Lys Glu Glu Lys Ser Gln Met Ala Cys Pro Asp Glu Asn Val Ser Ser
                245                 250                 255     
Gly Glu Leu Arg Gly Leu Cys Ala Ala Pro Arg Glu Glu Lys Glu Arg
            260                 265                 270         
Glu Thr Glu Ala Ala Gln Met Glu His Gln Lys Glu Arg Asn Ser Phe
        275                 280                 285             
Glu Glu Arg Ile Gln Ala Leu Glu Glu Asp Leu Arg Glu Lys Glu Arg
    290                 295                 300                 
Glu Ile Ala Thr Glu Lys Lys Asn Ser Leu Lys Arg Asp Lys Ala Ile
305                 310                 315                 320 
Gln Gly Leu Thr Met Ala Leu Lys Ser Lys Glu Lys Lys Val Glu Glu
                325                 330                 335     
Leu Asn Ser Glu Ile Glu Lys Leu Ser Ala Ala Phe Ala Lys Ala Arg
            340                 345                 350         
Glu Ala Leu Gln Lys Ala Gln Thr Gln Glu Phe Gln Gly Ser Glu Asp
        355                 360                 365             
Tyr Glu Thr Ala Leu Ser Gly Lys Glu Ala Leu Ser Ala Ala Leu Arg
    370                 375                 380                 
Ser Gln Asn Leu Thr Lys Ser Thr Glu Asn His Arg Leu Arg Arg Ser
385                 390                 395                 400 
Ile Lys Lys Ile Thr Gln Glu Leu Ser Asp Leu Gln Gln Glu Arg Glu
                405                 410                 415     
Arg Leu Glu Lys Asp Leu Glu Glu Ala His Arg Glu Lys Ser Lys Gly
            420                 425                 430         
Asp Cys Thr Ile Arg Asp Leu Arg Asn Glu Val Glu Lys Leu Arg Asn
        435                 440                 445             
Glu Val Asn Glu Arg Glu Lys Ala Met Glu Asn Arg Tyr Lys Ser Leu
    450                 455                 460                 
Leu Ser Glu Ser Asn Lys Lys Leu His Asn Gln Glu Gln Val Ile Lys
465                 470                 475                 480 
His Leu Thr Glu Ser Thr Asn Gln Lys Asp Val Leu Leu Gln Lys Phe
                485                 490                 495     
Asn Glu Lys Asp Leu Glu Val Ile Gln Gln Asn Cys Tyr Leu Met Ala
            500                 505                 510         
Ala Glu Asp Leu Glu Leu Arg Ser Glu Gly Leu Ile Thr Glu Lys Cys
        515                 520                 525             
Ser Ser Gln Gln Pro Pro Gly Ser Lys Thr Ile Phe Ser Lys Glu Lys
    530                 535                 540                 
Lys Gln Ser Ser Asp Tyr Glu Glu Leu Ile Gln Val Leu Lys Lys Glu
545                 550                 555                 560 
Gln Asp Ile Tyr Thr His Leu Val Lys Ser Leu Gln Glu Ser Asp Ser
                565                 570                 575     
Ile Asn Asn Leu Gln Ala Glu Leu Asn Lys Ile Phe Ala Leu Arg Lys
            580                 585                 590         
Gln Leu Glu Gln Asp Val Leu Ser Tyr Gln Asn Leu Arg Lys Thr Leu
        595                 600                 605             
Glu Glu Gln Ile Ser Glu Ile Arg Arg Arg Glu Glu Glu Ser Phe Ser
    610                 615                 620                 
Leu Tyr Ser Asp Gln Thr Ser Tyr Leu Ser Ile Cys Leu Glu Glu Asn
625                 630                 635                 640 
Asn Arg Phe Gln Val Glu His Phe Ser Gln Glu Glu Leu Lys Lys Lys
                645                 650                 655     
Val Ser Asp Leu Ile Gln Leu Val Lys Glu Leu Tyr Thr Asp Asn Gln
            660                 665                 670         
His Leu Lys Lys Thr Ile Phe Asp Leu Ser Cys Met Gly Phe Gln Gly
        675                 680                 685             
Asn Gly Phe Pro Asp Arg Leu Ala Ser Thr Glu Gln Thr Glu Leu Leu
    690                 695                 700                 
Ala Ser Lys Glu Asp Glu Asp Thr Ile Lys Ile Gly Glu Asp Asp Glu
705                 710                 715                 720 
Ile Asn Phe Leu Ser Asp Gln His Leu Gln Gln Ser Asn Glu Ile Met
                725                 730                 735     
Lys Asp Leu Ser Lys Gly Gly Cys Lys Asn Gly Tyr Leu Arg His Thr
            740                 745                 750         
Glu Ser Lys Ile Ser Asp Cys Asp Gly Ala His Ala Pro Gly Cys Leu
        755                 760                 765             
Glu Glu Gly Ala Phe Ile Asn Leu Leu Ala Pro Leu Phe Asn Glu Lys
    770                 775                 780                 
Ala Thr Leu Leu Leu Glu Ser Arg Pro Asp Leu Leu Lys Val Val Arg
785                 790                 795                 800 
Glu Leu Leu Leu Gly Gln Leu Phe Leu Thr Glu Gln Glu Val Ser Gly
                805                 810                 815     
Glu His Leu Asp Gly Lys Thr Glu Lys Thr Pro Lys Gln Lys Gly Glu
            820                 825                 830         
Leu Val His Phe Val Gln Thr Asn Ser Phe Ser Lys Pro His Asp Glu
        835                 840                 845             
Leu Lys Leu Ser Cys Glu Ala Gln Leu Val Lys Ala Gly Glu Val Pro
    850                 855                 860                 
Lys Val Gly Leu Lys Asp Ala Ser Val Gln Thr Val Ala Thr Glu Gly
865                 870                 875                 880 
Asp Leu Leu Arg Phe Lys His Glu Ala Thr Arg Glu Ala Trp Glu Glu
                885                 890                 895     
Lys Pro Ile Asn Thr Ala Leu Ser Ala Glu His Arg Pro Glu Asn Leu
            900                 905                 910         
His Gly Val Pro Gly Trp Gln Ala Ala Leu Leu Ser Leu Pro Gly Ile
        915                 920                 925             
Thr Asn Arg Glu Ala Lys Lys Ser Arg Leu Pro Ile Leu Ile Lys Pro
    930                 935                 940                 
Ser Arg Ser Leu Gly Asn Met Tyr Arg Leu Pro Ala Thr Gln Glu Val
945                 950                 955                 960 
Val Thr Gln Leu Gln Ser Gln Ile Leu Glu Leu Gln Gly Glu Leu Lys
                965                 970                 975     
Glu Phe Lys Thr Cys Asn Lys Gln Leu His Gln Lys Leu Ile Leu Ala
            980                 985                 990         
Glu Ala Val Met Glu Gly Arg Pro Thr Pro Asp Lys Thr Leu Leu Asn
        995                 1000                1005            
Ala Gln Pro Pro Val Gly Ala Ala Tyr Gln Asp Ser Pro Gly Glu Gln
    1010                1015                1020                
Lys Gly Ile Lys Thr Thr Ser Ser Val Trp Arg Asp Lys Glu Met Asp
1025                1030                1035                1040
Ser Asp Gln Gln Arg Ser Tyr Glu Ile Asp Ser Glu Ile Cys Pro Pro
                1045                1050                1055    
Asp Asp Leu Ala Ser Leu Pro Ser Cys Lys Glu Asn Pro Glu Asp Val
            1060                1065                1070        
Leu Ser Pro Thr Ser Val Ala Thr Tyr Leu Ser Ser Lys Ser Gln Pro
        1075                1080                1085            
Ser Ala Lys Val Ser Val Met Gly Thr Asp Gln Ser Glu Ser Ile Asn
    1090                1095                1100                
Thr Ser Asn Glu Thr Glu Tyr Leu Lys Gln Lys Ile His Asp Leu Glu
1105                1110                1115                1120
Thr Glu Leu Glu Gly Tyr Gln Asn Phe Ile Phe Gln Leu Gln Lys His
                1125                1130                1135    
Ser Gln Cys Ser Glu Ala Ile Ile Thr Val Leu Cys Gly Thr Glu Gly
            1140                1145                1150        
Ala Gln Asp Gly Leu Ser Lys Pro Lys Asn Gly Ser Asp Gly Glu Glu
        1155                1160                1165            
Met Thr Phe Ser Ser Leu His Gln Val Arg Tyr Val Lys His Val Lys
    1170                1175                1180                
Ile Leu Gly Pro Leu Ala Pro Glu Met Ile Asp Ser Arg Val Leu Glu
1185                1190                1195                1200
Asn Leu Lys Gln Gln Leu Glu Glu Gln Glu Tyr Lys Leu Gln Lys Glu
                1205                1210                1215    
Gln Asn Leu Asn Met Gln Leu Phe Ser Glu Ile His Asn Leu Gln Asn
            1220                1225                1230        
Lys Phe Arg Asp Leu Ser Pro Pro Arg Tyr Asp Ser Leu Val Gln Ser
        1235                1240                1245            
Gln Ala Arg Glu Leu Ser Leu Gln Arg Gln Gln Ile Lys Asp Gly His
    1250                1255                1260                
Gly Ile Cys Val Ile Ser Arg Gln His Met Asn Thr Met Ile Lys Ala
1265                1270                1275                1280
Phe Glu Glu Leu Leu Gln Ala Ser Asp Val Asp Tyr Cys Val Ala Glu
                1285                1290                1295    
Gly Phe Gln Glu Gln Leu Asn Gln Cys Ala Glu Leu Leu Glu Lys Leu
            1300                1305                1310        
Glu Lys Leu Phe Leu Asn Gly Lys Ser Val Gly Val Glu Met Asn Thr
        1315                1320                1325            
Gln Asn Glu Leu Met Glu Arg Ile Glu Glu Asp Asn Leu Thr Tyr Gln
    1330                1335                1340                
His Leu Leu Pro Glu Ser Pro Glu Pro Ser Ala Ser His Ala Leu Ser
1345                1350                1355                1360
Asp Tyr Glu Thr Ser Glu Lys Ser Phe Phe Ser Arg Asp Gln Lys Gln
                1365                1370                1375    
Asp Asn Glu Thr Glu Lys Thr Ser Val Met Val Asn Ser Phe Ser Gln
            1380                1385                1390        
Asp Leu Leu Met Glu His Ile Gln Glu Ile Arg Thr Leu Arg Lys Arg
        1395                1400                1405            
Leu Glu Glu Ser Ile Lys Thr Asn Glu Lys Leu Arg Lys Gln Leu Glu
    1410                1415                1420                
Arg Gln Gly Ser Glu Phe Val Gln Gly Ser Thr Ser Ile Phe Ala Ser
1425                1430                1435                1440
Gly Ser Glu Leu His Ser Ser Leu Thr Ser Glu Ile His Phe Leu Arg
                1445                1450                1455    
Lys Gln Asn Gln Ala Leu Asn Ala Met Leu Ile Lys Gly Ser Arg Asp
            1460                1465                1470        
Lys Gln Lys Glu Asn Asp Lys Leu Arg Glu Ser Leu Ser Arg Lys Thr
        1475                1480                1485            
Val Ser Leu Glu His Leu Gln Arg Glu Tyr Ala Ser Val Lys Glu Glu
    1490                1495                1500                
Asn Glu Arg Leu Gln Lys Glu Gly Ser Glu Lys Glu Arg His Asn Gln
1505                1510                1515                1520
Gln Leu Ile Gln Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Arg Val
                1525                1530                1535    
Gln Glu Glu Val Lys Leu Arg Gln Gln Leu Leu Ser Gln Asn Asp Lys
            1540                1545                1550        
Leu Leu Gln Ser Leu Arg Val Glu Leu Lys Ala Tyr Glu Lys Leu Asp
        1555                1560                1565            
Glu Glu His Arg Arg Leu Arg Glu Ala Ser Gly Glu Gly Trp Lys Gly
    1570                1575                1580                
Gln Asp Pro Phe Arg Asp Leu His Ser Leu Leu Met Glu Ile Gln Ala
1585                1590                1595                1600
Leu Arg Leu Gln Leu Glu Arg Ser Ile Glu Thr Ser Ser Thr Leu Gln
                1605                1610                1615    
Ser Arg Leu Lys Glu Gln Leu Ala Arg Gly Ala Glu Lys Ala Gln Glu
            1620                1625                1630        
Gly Ala Leu Thr Leu Ala Val Gln Ala Val Ser Ile Pro Glu Val Pro
        1635                1640                1645            
Leu Gln Pro Asp Lys His Asp Gly Asp Lys Tyr Pro Met Glu Ser Asp
    1650                1655                1660                
Asn Ser Phe Asp Leu Phe Asp Ser Ser Gln Ala Val Thr Pro Lys Ser
1665                1670                1675                1680
Val Ser Glu Thr Pro Pro Leu Ser Gly Asn Asp Thr Asp Ser Leu Ser
                1685                1690                1695    
Cys Asp Ser Gly Ser Ser Ala Thr Ser Thr Pro Cys Val Ser Arg Leu
            1700                1705                1710        
Val Thr Gly His His Leu Trp Ala Ser Lys Asn Gly Arg His Val Leu
        1715                1720                1725            
Gly Leu Ile Glu Asp Tyr Glu Ala Leu Leu Lys Gln Ile Ser Gln Gly
    1730                1735                1740                
Gln Arg Leu Leu Ala Glu Met Asp Ile Gln Thr Gln Glu Ala Pro Ser
1745                1750                1755                1760
Ser Thr Ser Gln Glu Leu Gly Thr Lys Gly Pro His Pro Ala Pro Leu
                1765                1770                1775    
Ser Lys Phe Val Ser Ser Val Ser Thr Ala Lys Leu Thr Leu Glu Glu
            1780                1785                1790        
Ala Tyr Arg Arg Leu Lys Leu Leu Trp Arg Val Ser Leu Pro Glu Asp
        1795                1800                1805            
Gly Gln Cys Pro Leu His Cys Glu Gln Ile Gly Glu Met Lys Ala Glu
    1810                1815                1820                
Val Thr Lys Leu His Lys Lys Leu Phe Glu Gln Glu Lys Lys Leu Gln
1825                1830                1835                1840
Asn Thr Met Lys Leu Leu Gln Leu Ser Lys Arg Gln Glu Lys Val Ile
                1845                1850                1855    
Phe Asp Gln Leu Val Val Thr His Lys Ile Leu Arg Lys Ala Arg Gly
            1860                1865                1870        
Asn Leu Glu Leu Arg Pro Gly Gly Ala His Pro Gly Thr Cys Ser Pro
        1875                1880                1885            
Ser Arg Pro Gly Ser
    1890            


<210> 6317
<211> 1893
<212> PRT
<213> Homo sapiens

<400> 6317
Met Met Asp Leu Val Leu Glu Glu Asp Val Thr Val Pro Gly Thr Leu
 1               5                  10                  15      
Ser Gly Cys Ser Gly Leu Val Pro Ser Val Pro Asp Asp Leu Asp Gly
            20                  25                  30          
Ile Asn Pro Asn Ala Gly Leu Gly Asn Gly Val Leu Pro Asn Val Ser
        35                  40                  45              
Glu Glu Thr Val Ser Pro Thr Arg Ala Arg Asn Met Lys Asp Phe Glu
    50                  55                  60                  
Asn Gln Ile Thr Glu Leu Lys Lys Glu Asn Phe Asn Leu Lys Leu Arg
65                  70                  75                  80  
Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln Glu Phe His Gly Pro Thr
                85                  90                  95      
Glu His Ile Tyr Lys Thr Asn Ile Glu Leu Lys Val Glu Val Glu Ser
            100                 105                 110         
Leu Lys Arg Glu Leu Gln Glu Arg Glu Gln Leu Leu Ile Lys Ala Ser
        115                 120                 125             
Lys Ala Val Glu Ser Leu Ala Glu Ala Gly Gly Ser Glu Ile Gln Arg
    130                 135                 140                 
Val Lys Glu Asp Ala Arg Lys Lys Val Gln Gln Val Glu Asp Leu Leu
145                 150                 155                 160 
Thr Lys Arg Ile Leu Leu Leu Glu Lys Asp Val Thr Ala Ala Gln Ala
                165                 170                 175     
Glu Leu Glu Lys Ala Phe Ala Gly Thr Glu Thr Glu Lys Ala Leu Arg
            180                 185                 190         
Leu Arg Leu Glu Ser Lys Leu Ser Glu Met Lys Lys Met His Glu Gly
        195                 200                 205             
Asp Leu Ala Met Ala Leu Val Leu Asp Glu Lys Asp Arg Leu Ile Glu
    210                 215                 220                 
Glu Leu Lys Leu Ser Leu Lys Ser Lys Glu Ala Leu Ile Gln Cys Leu
225                 230                 235                 240 
Lys Glu Glu Lys Ser Gln Met Ala Cys Pro Asp Glu Asn Val Ser Ser
                245                 250                 255     
Gly Glu Leu Arg Gly Leu Cys Ala Ala Pro Arg Glu Glu Lys Glu Arg
            260                 265                 270         
Glu Thr Glu Ala Ala Gln Met Glu His Gln Lys Glu Arg Asn Ser Phe
        275                 280                 285             
Glu Glu Arg Ile Gln Ala Leu Glu Glu Asp Leu Arg Glu Lys Glu Arg
    290                 295                 300                 
Glu Ile Ala Thr Glu Lys Lys Asn Ser Leu Lys Arg Asp Lys Ala Ile
305                 310                 315                 320 
Gln Gly Leu Thr Met Ala Leu Lys Ser Lys Glu Lys Lys Val Glu Glu
                325                 330                 335     
Leu Asn Ser Glu Ile Glu Lys Leu Ser Ala Ala Phe Ala Lys Ala Arg
            340                 345                 350         
Glu Ala Leu Gln Lys Ala Gln Thr Gln Glu Phe Gln Gly Ser Glu Asp
        355                 360                 365             
Tyr Glu Thr Ala Leu Ser Gly Lys Glu Ala Leu Ser Ala Ala Leu Arg
    370                 375                 380                 
Ser Gln Asn Leu Thr Lys Ser Thr Glu Asn His Arg Leu Arg Arg Ser
385                 390                 395                 400 
Ile Lys Lys Ile Thr Gln Glu Leu Ser Asp Leu Gln Gln Glu Arg Glu
                405                 410                 415     
Arg Leu Glu Lys Asp Leu Glu Glu Ala His Arg Glu Lys Ser Lys Gly
            420                 425                 430         
Asp Cys Thr Ile Arg Asp Leu Arg Asn Glu Val Glu Lys Leu Arg Asn
        435                 440                 445             
Glu Val Asn Glu Arg Glu Lys Ala Met Glu Asn Arg Tyr Lys Ser Leu
    450                 455                 460                 
Leu Ser Glu Ser Asn Lys Lys Leu His Asn Gln Glu Gln Val Ile Lys
465                 470                 475                 480 
His Leu Thr Glu Ser Thr Asn Gln Lys Asp Val Leu Leu Gln Lys Phe
                485                 490                 495     
Asn Glu Lys Asp Leu Glu Val Ile Gln Gln Asn Cys Tyr Leu Met Ala
            500                 505                 510         
Ala Glu Asp Leu Glu Leu Arg Ser Glu Gly Leu Ile Thr Glu Lys Cys
        515                 520                 525             
Ser Ser Gln Gln Pro Pro Gly Ser Lys Thr Ile Phe Ser Lys Glu Lys
    530                 535                 540                 
Lys Gln Ser Ser Asp Tyr Glu Glu Leu Ile Gln Val Leu Lys Lys Glu
545                 550                 555                 560 
Gln Asp Ile Tyr Thr His Leu Val Lys Ser Leu Gln Glu Ser Asp Ser
                565                 570                 575     
Ile Asn Asn Leu Gln Ala Glu Leu Asn Lys Ile Phe Ala Leu Arg Lys
            580                 585                 590         
Gln Leu Glu Gln Asp Val Leu Ser Tyr Gln Asn Leu Arg Lys Thr Leu
        595                 600                 605             
Glu Glu Gln Ile Ser Glu Ile Arg Arg Arg Glu Glu Glu Ser Phe Ser
    610                 615                 620                 
Leu Tyr Ser Asp Gln Thr Phe Tyr Leu Ser Ile Cys Leu Glu Glu Asn
625                 630                 635                 640 
Asn Arg Phe Gln Val Glu His Phe Ser Gln Glu Glu Leu Lys Lys Lys
                645                 650                 655     
Val Ser Asp Leu Ile Gln Leu Val Lys Glu Leu Tyr Thr Asp Asn Gln
            660                 665                 670         
His Leu Lys Lys Thr Ile Phe Asp Leu Ser Cys Met Gly Phe Gln Gly
        675                 680                 685             
Asn Gly Phe Pro Asp Arg Leu Ala Ser Thr Glu Gln Thr Glu Leu Leu
    690                 695                 700                 
Ala Ser Lys Glu Asp Glu Asp Thr Ile Lys Ile Gly Glu Asp Asp Glu
705                 710                 715                 720 
Ile Asn Phe Leu Ser Asp Gln His Leu Gln Gln Ser Asn Glu Ile Met
                725                 730                 735     
Lys Asp Leu Ser Lys Gly Gly Cys Lys Asn Gly Tyr Leu Arg His Thr
            740                 745                 750         
Glu Ser Lys Ile Ser Asp Cys Asp Gly Ala His Ala Pro Gly Cys Leu
        755                 760                 765             
Glu Glu Gly Ala Phe Ile Asn Leu Leu Ala Pro Leu Phe Asn Glu Lys
    770                 775                 780                 
Ala Thr Leu Leu Leu Glu Ser Arg Pro Asp Leu Leu Lys Val Val Arg
785                 790                 795                 800 
Glu Leu Leu Leu Gly Gln Leu Phe Leu Thr Glu Gln Glu Val Ser Gly
                805                 810                 815     
Glu His Leu Asp Gly Lys Thr Glu Lys Thr Pro Lys Gln Lys Gly Glu
            820                 825                 830         
Leu Val His Phe Val Gln Thr Asn Ser Phe Ser Lys Pro His Asp Glu
        835                 840                 845             
Leu Lys Leu Ser Cys Glu Ala Gln Leu Val Lys Ala Gly Glu Val Pro
    850                 855                 860                 
Lys Val Gly Leu Lys Asp Ala Ser Val Gln Thr Val Ala Thr Glu Gly
865                 870                 875                 880 
Asp Leu Leu Arg Phe Lys His Glu Ala Thr Arg Glu Ala Trp Glu Glu
                885                 890                 895     
Lys Pro Ile Asn Thr Ala Leu Ser Ala Glu His Arg Pro Glu Asn Leu
            900                 905                 910         
His Gly Val Pro Gly Trp Gln Ala Ala Leu Leu Ser Leu Pro Gly Ile
        915                 920                 925             
Thr Asn Arg Glu Ala Lys Lys Ser Arg Leu Pro Ile Leu Ile Lys Pro
    930                 935                 940                 
Ser Arg Ser Leu Gly Asn Met Tyr Arg Leu Pro Ala Thr Gln Glu Val
945                 950                 955                 960 
Val Thr Gln Leu Gln Ser Gln Ile Leu Glu Leu Gln Gly Glu Leu Lys
                965                 970                 975     
Glu Phe Lys Thr Cys Asn Lys Gln Leu His Gln Lys Leu Ile Leu Ala
            980                 985                 990         
Glu Ala Val Met Glu Gly Arg Pro Thr Pro Asp Lys Thr Leu Leu Asn
        995                 1000                1005            
Ala Gln Pro Pro Val Gly Ala Ala Tyr Gln Asp Ser Pro Gly Glu Gln
    1010                1015                1020                
Lys Gly Ile Lys Thr Thr Ser Ser Val Trp Arg Asp Lys Glu Met Asp
1025                1030                1035                1040
Ser Asp Gln Gln Arg Ser Tyr Glu Ile Asp Ser Glu Ile Cys Pro Pro
                1045                1050                1055    
Asp Asp Leu Ala Ser Leu Pro Ser Cys Lys Glu Asn Pro Glu Asp Val
            1060                1065                1070        
Leu Ser Pro Thr Ser Val Ala Thr Tyr Leu Ser Ser Lys Ser Gln Pro
        1075                1080                1085            
Ser Ala Lys Val Ser Val Met Gly Thr Asp Gln Ser Glu Ser Ile Asn
    1090                1095                1100                
Thr Ser Asn Glu Thr Glu Tyr Leu Lys Gln Lys Ile His Asp Leu Glu
1105                1110                1115                1120
Thr Glu Leu Glu Gly Tyr Gln Asn Phe Ile Phe Gln Leu Gln Lys His
                1125                1130                1135    
Ser Gln Cys Ser Glu Ala Ile Ile Thr Val Leu Cys Gly Thr Glu Gly
            1140                1145                1150        
Ala Gln Asp Gly Leu Ser Lys Pro Lys Asn Gly Ser Asp Gly Glu Glu
        1155                1160                1165            
Met Thr Phe Ser Ser Leu His Gln Val Arg Tyr Val Lys His Val Lys
    1170                1175                1180                
Ile Leu Gly Pro Leu Ala Pro Glu Met Ile Asp Ser Arg Val Leu Glu
1185                1190                1195                1200
Asn Leu Lys Gln Gln Leu Glu Glu Gln Glu Tyr Lys Leu Gln Lys Glu
                1205                1210                1215    
Gln Asn Leu Asn Met Gln Leu Phe Ser Glu Ile His Asn Leu Gln Asn
            1220                1225                1230        
Lys Phe Arg Asp Leu Ser Pro Pro Arg Tyr Asp Ser Leu Val Gln Ser
        1235                1240                1245            
Gln Ala Arg Glu Leu Ser Leu Gln Arg Gln Gln Ile Lys Asp Gly His
    1250                1255                1260                
Gly Ile Cys Val Ile Ser Arg Gln His Met Asn Thr Met Ile Lys Ala
1265                1270                1275                1280
Phe Glu Glu Leu Leu Gln Ala Ser Asp Val Asp Tyr Cys Val Ala Glu
                1285                1290                1295    
Gly Phe Gln Glu Gln Leu Asn Gln Cys Ala Glu Leu Leu Glu Lys Leu
            1300                1305                1310        
Glu Lys Leu Phe Leu Asn Gly Lys Ser Val Gly Val Glu Met Asn Thr
        1315                1320                1325            
Gln Asn Glu Leu Met Glu Arg Ile Glu Glu Asp Asn Leu Thr Tyr Gln
    1330                1335                1340                
His Leu Leu Pro Glu Ser Pro Glu Pro Ser Ala Ser His Ala Leu Ser
1345                1350                1355                1360
Asp Tyr Glu Thr Ser Glu Lys Ser Phe Phe Ser Arg Asp Gln Lys Gln
                1365                1370                1375    
Asp Asn Glu Thr Glu Lys Thr Ser Val Met Val Asn Ser Phe Ser Gln
            1380                1385                1390        
Asp Leu Leu Met Glu His Ile Gln Glu Ile Arg Thr Leu Arg Lys Arg
        1395                1400                1405            
Leu Glu Glu Ser Ile Lys Thr Asn Glu Lys Leu Arg Lys Gln Leu Glu
    1410                1415                1420                
Arg Gln Gly Ser Glu Phe Val Gln Gly Ser Thr Ser Ile Phe Ala Ser
1425                1430                1435                1440
Gly Ser Glu Leu His Ser Ser Leu Thr Ser Glu Ile His Phe Leu Arg
                1445                1450                1455    
Lys Gln Asn Gln Ala Leu Asn Ala Met Leu Ile Lys Gly Ser Arg Asp
            1460                1465                1470        
Lys Gln Lys Glu Asn Asp Lys Leu Arg Glu Ser Leu Ser Arg Lys Thr
        1475                1480                1485            
Val Ser Leu Glu His Leu Gln Arg Glu Tyr Ala Ser Val Lys Glu Glu
    1490                1495                1500                
Asn Glu Arg Leu Gln Lys Glu Gly Ser Glu Lys Glu Arg His Asn Gln
1505                1510                1515                1520
Gln Leu Ile Gln Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Arg Val
                1525                1530                1535    
Gln Glu Glu Leu Lys Leu Arg Gln Gln Leu Leu Ser Gln Asn Asp Lys
            1540                1545                1550        
Leu Leu Gln Ser Leu Arg Val Glu Leu Lys Ala Tyr Glu Lys Leu Asp
        1555                1560                1565            
Glu Glu His Arg Arg Leu Arg Glu Ala Ser Gly Glu Gly Trp Lys Gly
    1570                1575                1580                
Gln Asp Pro Phe Arg Asp Leu His Ser Leu Leu Met Glu Ile Gln Ala
1585                1590                1595                1600
Leu Arg Leu Gln Leu Glu Arg Ser Ile Glu Thr Ser Ser Thr Leu Gln
                1605                1610                1615    
Ser Arg Leu Lys Glu Gln Leu Ala Arg Gly Ala Glu Lys Ala Gln Glu
            1620                1625                1630        
Gly Ala Leu Thr Leu Ala Val Gln Ala Val Ser Ile Pro Glu Val Pro
        1635                1640                1645            
Leu Gln Pro Asp Lys His Asp Gly Asp Lys Tyr Pro Met Glu Ser Asp
    1650                1655                1660                
Asn Ser Phe Asp Leu Phe Asp Ser Ser Gln Ala Val Thr Pro Lys Ser
1665                1670                1675                1680
Val Ser Glu Thr Pro Pro Leu Ser Gly Asn Asp Thr Asp Ser Leu Ser
                1685                1690                1695    
Cys Asp Ser Gly Ser Ser Ala Thr Ser Thr Pro Cys Val Ser Arg Leu
            1700                1705                1710        
Val Thr Gly His His Leu Trp Ala Ser Lys Asn Gly Arg His Val Leu
        1715                1720                1725            
Gly Leu Ile Glu Asp Tyr Glu Ala Leu Leu Lys Gln Ile Ser Gln Gly
    1730                1735                1740                
Gln Arg Leu Leu Ala Glu Met Asp Ile Gln Thr Gln Glu Ala Pro Ser
1745                1750                1755                1760
Ser Thr Ser Gln Glu Leu Gly Thr Lys Gly Pro His Pro Ala Pro Leu
                1765                1770                1775    
Ser Lys Phe Val Ser Ser Val Ser Thr Ala Lys Leu Thr Leu Glu Glu
            1780                1785                1790        
Ala Tyr Arg Arg Leu Lys Leu Leu Trp Arg Val Ser Leu Pro Glu Asp
        1795                1800                1805            
Gly Gln Cys Pro Leu His Cys Glu Gln Ile Gly Glu Met Lys Ala Glu
    1810                1815                1820                
Val Thr Lys Leu His Lys Lys Leu Phe Glu Gln Glu Lys Lys Leu Gln
1825                1830                1835                1840
Asn Thr Met Lys Leu Leu Gln Leu Ser Lys Arg Gln Glu Lys Val Ile
                1845                1850                1855    
Phe Asp Gln Leu Val Val Thr His Lys Ile Leu Arg Lys Ala Arg Gly
            1860                1865                1870        
Asn Leu Glu Leu Arg Pro Gly Gly Ala His Pro Gly Thr Cys Ser Pro
        1875                1880                1885            
Ser Arg Pro Gly Ser
    1890            


<210> 6318
<211> 1852
<212> PRT
<213> Homo sapiens

<400> 6318
Met Met Asp Leu Val Leu Glu Glu Asp Val Thr Val Pro Gly Thr Leu
 1               5                  10                  15      
Ser Gly Cys Ser Gly Leu Val Pro Ser Val Pro Asp Asp Leu Asp Gly
            20                  25                  30          
Ile Asn Pro Asn Ala Gly Leu Gly Asn Gly Val Leu Pro Asn Val Ser
        35                  40                  45              
Glu Glu Thr Val Ser Pro Thr Arg Ala Arg Asn Met Lys Asp Phe Glu
    50                  55                  60                  
Asn Gln Ile Thr Glu Leu Lys Lys Glu Asn Phe Asn Leu Lys Leu Arg
65                  70                  75                  80  
Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln Glu Phe His Gly Pro Thr
                85                  90                  95      
Glu His Ile Tyr Lys Thr Asn Ile Glu Leu Lys Val Glu Val Glu Ser
            100                 105                 110         
Leu Lys Arg Glu Leu Gln Glu Arg Glu Gln Leu Leu Ile Lys Ala Ser
        115                 120                 125             
Lys Ala Val Glu Ser Leu Ala Glu Ala Gly Gly Ser Glu Ile Gln Arg
    130                 135                 140                 
Val Lys Glu Asp Ala Arg Lys Lys Val Gln Gln Val Glu Asp Leu Leu
145                 150                 155                 160 
Thr Lys Arg Ile Leu Leu Leu Glu Lys Asp Val Thr Ala Ala Gln Ala
                165                 170                 175     
Glu Leu Glu Lys Ala Phe Ala Gly Thr Glu Thr Glu Lys Ala Leu Arg
            180                 185                 190         
Leu Arg Leu Glu Ser Lys Leu Ser Glu Met Lys Lys Met His Glu Gly
        195                 200                 205             
Asp Leu Ala Met Ala Leu Val Leu Asp Glu Lys Asp Arg Leu Ile Glu
    210                 215                 220                 
Glu Leu Lys Leu Ser Leu Lys Ser Lys Glu Ala Leu Ile Gln Cys Leu
225                 230                 235                 240 
Lys Glu Glu Lys Ser Gln Met Ala Cys Pro Asp Glu Asn Val Ser Ser
                245                 250                 255     
Gly Glu Leu Arg Gly Leu Cys Ala Ala Pro Arg Glu Glu Lys Glu Arg
            260                 265                 270         
Glu Thr Glu Ala Ala Gln Met Glu His Gln Lys Glu Arg Asn Ser Phe
        275                 280                 285             
Glu Glu Arg Ile Gln Ala Leu Glu Glu Asp Leu Arg Glu Lys Glu Arg
    290                 295                 300                 
Glu Ile Ala Thr Glu Lys Lys Asn Ser Leu Lys Arg Asp Lys Ala Ile
305                 310                 315                 320 
Gln Gly Leu Thr Met Ala Leu Lys Ser Lys Glu Lys Lys Val Glu Glu
                325                 330                 335     
Leu Asn Ser Glu Ile Glu Lys Leu Ser Ala Ala Phe Ala Lys Ala Arg
            340                 345                 350         
Glu Ala Leu Gln Lys Ala Gln Thr Gln Glu Phe Gln Gly Ser Glu Asp
        355                 360                 365             
Tyr Glu Thr Ala Leu Ser Gly Lys Glu Ala Leu Ser Ala Ala Leu Arg
    370                 375                 380                 
Ser Gln Asn Leu Thr Lys Ser Thr Glu Asn His Arg Leu Arg Arg Ser
385                 390                 395                 400 
Ile Lys Lys Ile Thr Gln Glu Leu Ser Asp Leu Gln Gln Glu Arg Glu
                405                 410                 415     
Arg Leu Glu Lys Asp Leu Glu Glu Ala His Arg Glu Lys Ser Lys Gly
            420                 425                 430         
Asp Cys Thr Ile Arg Asp Leu Arg Asn Glu Val Glu Lys Leu Arg Asn
        435                 440                 445             
Glu Val Asn Glu Arg Glu Lys Ala Met Glu Asn Arg Tyr Lys Ser Leu
    450                 455                 460                 
Leu Ser Glu Ser Asn Lys Lys Leu His Asn Gln Glu Gln Val Ile Lys
465                 470                 475                 480 
His Leu Thr Glu Ser Thr Asn Gln Lys Asp Val Leu Leu Gln Lys Phe
                485                 490                 495     
Asn Glu Lys Asp Leu Glu Val Ile Gln Gln Asn Cys Tyr Leu Met Ala
            500                 505                 510         
Ala Glu Asp Leu Glu Leu Arg Ser Glu Gly Leu Ile Thr Glu Lys Cys
        515                 520                 525             
Ser Ser Gln Gln Pro Pro Gly Ser Lys Thr Ile Phe Ser Lys Glu Lys
    530                 535                 540                 
Lys Gln Ser Ser Asp Tyr Glu Glu Leu Ile Gln Val Leu Lys Lys Glu
545                 550                 555                 560 
Gln Asp Ile Tyr Thr His Leu Val Lys Ser Leu Gln Glu Ser Asp Ser
                565                 570                 575     
Ile Asn Asn Leu Gln Ala Glu Leu Asn Lys Ile Phe Ala Leu Arg Lys
            580                 585                 590         
Gln Leu Glu Gln Asp Val Leu Ser Tyr Gln Asn Leu Arg Lys Thr Leu
        595                 600                 605             
Glu Glu Gln Ile Ser Glu Ile Arg Arg Arg Glu Glu Glu Ser Phe Ser
    610                 615                 620                 
Leu Tyr Ser Asp Gln Thr Phe Tyr Leu Ser Ile Cys Leu Glu Glu Asn
625                 630                 635                 640 
Asn Arg Phe Gln Val Glu His Phe Ser Gln Glu Glu Leu Lys Lys Lys
                645                 650                 655     
Val Ser Asp Leu Ile Gln Leu Val Lys Glu Leu Tyr Thr Asp Asn Gln
            660                 665                 670         
His Leu Lys Lys Thr Ile Phe Asp Leu Ser Cys Met Gly Phe Gln Gly
        675                 680                 685             
Asn Gly Phe Pro Asp Arg Leu Ala Ser Thr Glu Gln Thr Glu Leu Leu
    690                 695                 700                 
Ala Ser Lys Glu Asp Glu Asp Thr Ile Lys Ile Gly Glu Asp Asp Glu
705                 710                 715                 720 
Ile Asn Phe Leu Ser Asp Gln His Leu Gln Gln Ser Asn Glu Ile Met
                725                 730                 735     
Lys Asp Leu Ser Lys Gly Gly Cys Lys Asn Gly Tyr Leu Arg His Thr
            740                 745                 750         
Glu Ser Lys Ile Ser Asp Cys Asp Gly Ala His Ala Pro Gly Cys Leu
        755                 760                 765             
Glu Glu Gly Ala Phe Ile Asn Leu Leu Ala Pro Leu Phe Asn Glu Lys
    770                 775                 780                 
Ala Thr Leu Leu Leu Glu Ser Arg Pro Asp Leu Leu Lys Val Val Arg
785                 790                 795                 800 
Glu Leu Leu Leu Gly Gln Leu Phe Leu Thr Glu Gln Glu Val Ser Gly
                805                 810                 815     
Glu His Leu Asp Gly Lys Thr Glu Lys Thr Pro Lys Gln Lys Gly Glu
            820                 825                 830         
Leu Val His Phe Val Gln Thr Asn Ser Phe Ser Lys Pro His Asp Glu
        835                 840                 845             
Leu Lys Leu Ser Cys Glu Ala Gln Leu Val Lys Ala Gly Glu Val Pro
    850                 855                 860                 
Lys Val Gly Leu Lys Asp Ala Ser Val Gln Thr Val Ala Thr Glu Gly
865                 870                 875                 880 
Asp Leu Leu Arg Phe Lys His Glu Ala Thr Arg Glu Ala Trp Glu Glu
                885                 890                 895     
Lys Pro Ile Asn Thr Ala Leu Ser Ala Glu His Arg Pro Glu Asn Leu
            900                 905                 910         
His Gly Val Pro Gly Trp Gln Ala Ala Leu Leu Ser Leu Pro Gly Ile
        915                 920                 925             
Thr Asn Arg Glu Ala Lys Lys Ser Arg Leu Pro Ile Leu Ile Lys Pro
    930                 935                 940                 
Ser Arg Ser Leu Gly Asn Met Tyr Arg Leu Pro Ala Thr Gln Glu Val
945                 950                 955                 960 
Val Thr Gln Leu Gln Ser Gln Ile Leu Glu Leu Gln Gly Glu Leu Lys
                965                 970                 975     
Glu Phe Lys Thr Cys Asn Lys Gln Leu His Gln Lys Leu Ile Leu Ala
            980                 985                 990         
Glu Ala Val Met Glu Gly Arg Pro Thr Pro Asp Lys Thr Leu Leu Asn
        995                 1000                1005            
Asp Ser Glu Ile Cys Pro Pro Asp Asp Leu Ala Ser Leu Pro Ser Cys
    1010                1015                1020                
Lys Glu Asn Pro Glu Asp Val Leu Ser Pro Thr Ser Val Ala Thr Tyr
1025                1030                1035                1040
Leu Ser Ser Lys Ser Gln Pro Ser Ala Lys Val Ser Val Met Gly Thr
                1045                1050                1055    
Asp Gln Ser Glu Ser Ile Asn Thr Ser Asn Glu Thr Glu Tyr Leu Lys
            1060                1065                1070        
Gln Lys Ile His Asp Leu Glu Thr Glu Leu Glu Gly Tyr Gln Asn Phe
        1075                1080                1085            
Ile Phe Gln Leu Gln Lys His Ser Gln Cys Ser Glu Ala Ile Ile Thr
    1090                1095                1100                
Val Leu Cys Gly Thr Glu Gly Ala Gln Asp Gly Leu Ser Lys Pro Lys
1105                1110                1115                1120
Asn Gly Ser Asp Gly Glu Glu Met Thr Phe Ser Ser Leu His Gln Val
                1125                1130                1135    
Arg Tyr Val Lys His Val Lys Ile Leu Gly Pro Leu Ala Pro Glu Met
            1140                1145                1150        
Ile Asp Ser Arg Val Leu Glu Asn Leu Lys Gln Gln Leu Glu Glu Gln
        1155                1160                1165            
Glu Tyr Lys Leu Gln Lys Glu Gln Asn Leu Asn Met Gln Leu Phe Ser
    1170                1175                1180                
Glu Ile His Asn Leu Gln Asn Lys Phe Arg Asp Leu Ser Pro Pro Arg
1185                1190                1195                1200
Tyr Asp Ser Leu Val Gln Ser Gln Ala Arg Glu Leu Ser Leu Gln Arg
                1205                1210                1215    
Gln Gln Ile Lys Asp Gly His Gly Ile Cys Val Ile Ser Arg Gln His
            1220                1225                1230        
Met Asn Thr Met Ile Lys Ala Phe Glu Glu Leu Leu Gln Ala Ser Asp
        1235                1240                1245            
Val Asp Tyr Cys Val Ala Glu Gly Phe Gln Glu Gln Leu Asn Gln Cys
    1250                1255                1260                
Ala Glu Leu Leu Glu Lys Leu Glu Lys Leu Phe Leu Asn Gly Lys Ser
1265                1270                1275                1280
Val Gly Val Glu Met Asn Thr Gln Asn Glu Leu Met Glu Arg Ile Glu
                1285                1290                1295    
Glu Asp Asn Leu Thr Tyr Gln His Leu Leu Pro Glu Ser Pro Glu Pro
            1300                1305                1310        
Ser Ala Ser His Ala Leu Ser Asp Tyr Glu Thr Ser Glu Lys Ser Phe
        1315                1320                1325            
Phe Ser Arg Asp Gln Lys Gln Asp Asn Glu Thr Glu Lys Thr Ser Val
    1330                1335                1340                
Met Val Asn Ser Phe Ser Gln Asp Leu Leu Met Glu His Ile Gln Glu
1345                1350                1355                1360
Ile Arg Thr Leu Arg Lys Arg Leu Glu Glu Ser Ile Lys Thr Asn Glu
                1365                1370                1375    
Lys Leu Arg Lys Gln Leu Glu Arg Gln Gly Ser Glu Phe Val Gln Gly
            1380                1385                1390        
Ser Thr Ser Ile Phe Ala Ser Gly Ser Glu Leu His Ser Ser Leu Thr
        1395                1400                1405            
Ser Glu Ile His Phe Leu Arg Lys Gln Asn Gln Ala Leu Asn Ala Met
    1410                1415                1420                
Leu Ile Lys Gly Ser Arg Asp Lys Gln Lys Glu Asn Asp Lys Leu Arg
1425                1430                1435                1440
Glu Ser Leu Ser Arg Lys Thr Val Ser Leu Glu His Leu Gln Arg Glu
                1445                1450                1455    
Tyr Ala Ser Val Lys Glu Glu Asn Glu Arg Leu Gln Lys Glu Gly Ser
            1460                1465                1470        
Glu Lys Glu Arg His Asn Gln Gln Leu Ile Gln Glu Val Arg Cys Ser
        1475                1480                1485            
Gly Gln Glu Leu Ser Arg Val Gln Glu Glu Leu Lys Leu Arg Gln Gln
    1490                1495                1500                
Leu Leu Ser Gln Asn Asp Lys Leu Leu Gln Ser Leu Arg Val Glu Leu
1505                1510                1515                1520
Lys Ala Tyr Glu Lys Leu Asp Glu Glu His Arg Arg Leu Arg Glu Ala
                1525                1530                1535    
Ser Gly Glu Gly Trp Lys Gly Gln Asp Pro Phe Arg Asp Leu His Ser
            1540                1545                1550        
Leu Leu Met Glu Ile Gln Ala Leu Arg Leu Gln Leu Glu Arg Ser Ile
        1555                1560                1565            
Glu Thr Ser Ser Thr Leu Gln Ser Arg Leu Lys Glu Gln Leu Ala Arg
    1570                1575                1580                
Gly Ala Glu Lys Ala Gln Glu Gly Ala Leu Thr Leu Ala Val Gln Ala
1585                1590                1595                1600
Val Ser Ile Pro Glu Val Pro Leu Gln Pro Asp Lys His Asp Gly Asp
                1605                1610                1615    
Lys Tyr Pro Met Glu Ser Asp Asn Ser Phe Asp Leu Phe Asp Ser Ser
            1620                1625                1630        
Gln Ala Val Thr Pro Lys Ser Val Ser Glu Thr Pro Pro Leu Ser Gly
        1635                1640                1645            
Asn Asp Thr Asp Ser Leu Ser Cys Asp Ser Gly Ser Ser Ala Thr Ser
    1650                1655                1660                
Thr Pro Cys Val Ser Arg Leu Val Thr Gly His His Leu Trp Ala Ser
1665                1670                1675                1680
Lys Asn Gly Arg His Val Leu Gly Leu Ile Glu Asp Tyr Glu Ala Leu
                1685                1690                1695    
Leu Lys Gln Ile Ser Gln Gly Gln Arg Leu Leu Ala Glu Met Asp Ile
            1700                1705                1710        
Gln Thr Gln Glu Ala Pro Ser Ser Thr Ser Gln Glu Leu Gly Thr Lys
        1715                1720                1725            
Gly Pro His Pro Ala Pro Leu Ser Lys Phe Val Ser Ser Val Ser Thr
    1730                1735                1740                
Ala Lys Leu Thr Leu Glu Glu Ala Tyr Arg Arg Leu Lys Leu Leu Trp
1745                1750                1755                1760
Arg Val Ser Leu Pro Glu Asp Gly Gln Cys Pro Leu His Cys Glu Gln
                1765                1770                1775    
Ile Gly Glu Met Lys Ala Glu Val Thr Lys Leu His Lys Lys Leu Phe
            1780                1785                1790        
Glu Gln Glu Lys Lys Leu Gln Asn Thr Met Lys Leu Leu Gln Leu Ser
        1795                1800                1805            
Lys Arg Gln Glu Lys Val Ile Phe Asp Gln Leu Val Val Thr His Lys
    1810                1815                1820                
Ile Leu Arg Lys Ala Arg Gly Asn Leu Glu Leu Arg Pro Gly Gly Ala
1825                1830                1835                1840
His Pro Gly Thr Cys Ser Pro Ser Arg Pro Gly Ser
                1845                1850        


<210> 6319
<211> 1814
<212> PRT
<213> Homo sapiens

<400> 6319
Met Met Asp Leu Val Leu Glu Glu Asp Val Thr Val Pro Gly Thr Leu
 1               5                  10                  15      
Ser Gly Cys Ser Gly Leu Val Pro Ser Val Pro Asp Asp Leu Asp Gly
            20                  25                  30          
Ile Asn Pro Asn Ala Gly Leu Gly Asn Gly Val Leu Pro Asn Val Ser
        35                  40                  45              
Glu Glu Thr Val Ser Pro Thr Arg Ala Arg Asn Met Lys Asp Phe Glu
    50                  55                  60                  
Asn Gln Ile Thr Glu Leu Lys Lys Glu Asn Phe Asn Leu Lys Leu Arg
65                  70                  75                  80  
Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln Glu Phe His Gly Pro Thr
                85                  90                  95      
Glu His Ile Tyr Lys Thr Asn Ile Glu Leu Lys Val Glu Val Glu Ser
            100                 105                 110         
Leu Lys Arg Glu Leu Gln Glu Arg Glu Gln Leu Leu Ile Lys Ala Ser
        115                 120                 125             
Lys Ala Val Glu Ser Leu Ala Glu Ala Gly Gly Ser Glu Ile Gln Arg
    130                 135                 140                 
Val Lys Glu Asp Ala Arg Lys Lys Val Gln Gln Val Glu Asp Leu Leu
145                 150                 155                 160 
Thr Lys Arg Ile Leu Leu Leu Glu Lys Asp Val Thr Ala Ala Gln Ala
                165                 170                 175     
Glu Leu Glu Lys Ala Phe Ala Gly Thr Glu Thr Glu Lys Ala Leu Arg
            180                 185                 190         
Leu Arg Leu Glu Ser Lys Leu Ser Glu Met Lys Lys Met His Glu Gly
        195                 200                 205             
Asp Leu Ala Met Ala Leu Val Leu Asp Glu Lys Asp Arg Leu Ile Glu
    210                 215                 220                 
Glu Leu Lys Leu Ser Leu Lys Ser Lys Glu Ala Leu Ile Gln Cys Leu
225                 230                 235                 240 
Lys Glu Glu Lys Ser Gln Met Ala Cys Pro Asp Glu Asn Val Ser Ser
                245                 250                 255     
Gly Glu Leu Arg Gly Leu Cys Ala Ala Pro Arg Glu Glu Lys Glu Arg
            260                 265                 270         
Glu Thr Glu Ala Ala Gln Met Glu His Gln Lys Glu Arg Asn Ser Phe
        275                 280                 285             
Glu Glu Arg Ile Gln Ala Leu Glu Glu Asp Leu Arg Glu Lys Glu Arg
    290                 295                 300                 
Glu Ile Ala Thr Glu Lys Lys Asn Ser Leu Lys Arg Asp Lys Ala Ile
305                 310                 315                 320 
Gln Gly Leu Thr Met Ala Leu Lys Ser Lys Glu Lys Lys Val Glu Glu
                325                 330                 335     
Leu Asn Ser Glu Ile Glu Lys Leu Ser Ala Ala Phe Ala Lys Ala Arg
            340                 345                 350         
Glu Ala Leu Gln Lys Ala Gln Thr Gln Glu Phe Gln Gly Ser Glu Asp
        355                 360                 365             
Tyr Glu Thr Ala Leu Ser Gly Lys Glu Ala Leu Ser Ala Ala Leu Arg
    370                 375                 380                 
Ser Gln Asn Leu Thr Lys Ser Thr Glu Asn His Arg Leu Arg Arg Ser
385                 390                 395                 400 
Ile Lys Lys Ile Thr Gln Glu Leu Ser Asp Leu Gln Gln Glu Arg Glu
                405                 410                 415     
Arg Leu Glu Lys Asp Leu Glu Glu Ala His Arg Glu Lys Ser Lys Gly
            420                 425                 430         
Asp Cys Thr Ile Arg Asp Leu Arg Asn Glu Val Glu Lys Leu Arg Asn
        435                 440                 445             
Glu Val Asn Glu Arg Glu Lys Ala Met Glu Asn Arg Tyr Lys Ser Leu
    450                 455                 460                 
Leu Ser Glu Ser Asn Lys Lys Leu His Asn Gln Glu Gln Val Ile Lys
465                 470                 475                 480 
His Leu Thr Glu Ser Thr Asn Gln Lys Asp Val Leu Leu Gln Lys Phe
                485                 490                 495     
Asn Glu Lys Asp Leu Glu Val Ile Gln Gln Asn Cys Tyr Leu Met Ala
            500                 505                 510         
Ala Glu Asp Leu Glu Leu Arg Ser Glu Gly Leu Ile Thr Glu Lys Cys
        515                 520                 525             
Ser Ser Gln Gln Pro Pro Gly Ser Lys Thr Ile Phe Ser Lys Glu Lys
    530                 535                 540                 
Lys Gln Ser Ser Asp Tyr Glu Glu Leu Ile Gln Val Leu Lys Lys Glu
545                 550                 555                 560 
Gln Asp Ile Tyr Thr His Leu Val Lys Ser Leu Gln Glu Ser Asp Ser
                565                 570                 575     
Ile Asn Asn Leu Gln Ala Glu Leu Asn Lys Ile Phe Ala Leu Arg Lys
            580                 585                 590         
Gln Leu Glu Gln Asp Val Leu Ser Tyr Gln Asn Leu Arg Lys Thr Leu
        595                 600                 605             
Glu Glu Gln Ile Ser Glu Ile Arg Arg Arg Glu Glu Glu Ser Phe Ser
    610                 615                 620                 
Leu Tyr Ser Asp Gln Thr Phe Tyr Leu Ser Ile Cys Leu Glu Glu Asn
625                 630                 635                 640 
Asn Arg Phe Gln Val Glu His Phe Ser Gln Glu Glu Leu Lys Lys Lys
                645                 650                 655     
Val Ser Asp Leu Ile Gln Leu Val Lys Glu Leu Tyr Thr Asp Asn Gln
            660                 665                 670         
His Leu Lys Lys Thr Ile Phe Asp Leu Ser Cys Met Gly Phe Gln Gly
        675                 680                 685             
Asn Gly Phe Pro Asp Arg Leu Ala Ser Thr Glu Gln Thr Glu Leu Leu
    690                 695                 700                 
Ala Ser Lys Glu Asp Glu Asp Thr Ile Lys Ile Gly Glu Asp Asp Glu
705                 710                 715                 720 
Ile Asn Phe Leu Ser Asp Gln His Leu Gln Gln Ser Asn Glu Ile Met
                725                 730                 735     
Lys Asp Leu Ser Lys Gly Gly Cys Lys Asn Gly Tyr Leu Arg His Thr
            740                 745                 750         
Glu Ser Lys Ile Ser Asp Cys Asp Gly Ala His Ala Pro Gly Cys Leu
        755                 760                 765             
Glu Glu Gly Ala Phe Ile Asn Leu Leu Ala Pro Leu Phe Asn Glu Lys
    770                 775                 780                 
Ala Thr Leu Leu Leu Glu Ser Arg Pro Asp Leu Leu Lys Val Val Arg
785                 790                 795                 800 
Glu Leu Leu Leu Gly Gln Leu Phe Leu Thr Glu Gln Glu Val Ser Gly
                805                 810                 815     
Glu His Leu Asp Gly Lys Thr Glu Lys Thr Pro Lys Gln Lys Gly Glu
            820                 825                 830         
Leu Val His Phe Val Gln Thr Asn Ser Phe Ser Lys Pro His Asp Glu
        835                 840                 845             
Leu Lys Leu Ser Cys Glu Ala Gln Leu Val Lys Ala Gly Glu Val Pro
    850                 855                 860                 
Lys Val Gly Leu Lys Asp Ala Ser Val Gln Thr Val Ala Thr Glu Gly
865                 870                 875                 880 
Asp Leu Leu Arg Phe Lys His Glu Ala Thr Arg Glu Ala Trp Glu Glu
                885                 890                 895     
Lys Pro Ile Asn Thr Ala Leu Ser Ala Glu His Arg Pro Glu Asn Leu
            900                 905                 910         
His Gly Val Pro Gly Trp Gln Ala Ala Leu Leu Ser Leu Pro Gly Ile
        915                 920                 925             
Thr Asn Arg Glu Ala Lys Lys Ser Arg Leu Pro Ile Leu Ile Lys Pro
    930                 935                 940                 
Ser Arg Ser Leu Gly Asn Met Tyr Arg Leu Pro Ala Thr Gln Glu Val
945                 950                 955                 960 
Val Thr Gln Leu Gln Ser Gln Ile Leu Glu Leu Gln Gly Glu Leu Lys
                965                 970                 975     
Glu Phe Lys Thr Cys Asn Lys Gln Leu His Gln Lys Leu Ile Leu Ala
            980                 985                 990         
Glu Ala Val Met Glu Gly Arg Pro Thr Pro Asp Lys Thr Leu Leu Asn
        995                 1000                1005            
Ala Gln Pro Pro Val Gly Ala Ala Tyr Gln Asp Ser Pro Gly Glu Gln
    1010                1015                1020                
Lys Gly Ile Lys Thr Thr Ser Ser Val Trp Arg Asp Lys Glu Met Asp
1025                1030                1035                1040
Ser Asp Gln Gln Arg Ser Tyr Glu Ile Asp Ser Glu Ile Cys Pro Pro
                1045                1050                1055    
Asp Asp Leu Ala Ser Leu Pro Ser Cys Lys Glu Asn Pro Glu Asp Val
            1060                1065                1070        
Leu Ser Pro Thr Ser Val Ala Thr Tyr Leu Ser Ser Lys Ser Gln Pro
        1075                1080                1085            
Ser Ala Lys Val Ser Val Met Gly Thr Asp Gln Ser Glu Ser Ile Asn
    1090                1095                1100                
Thr Ser Asn Glu Thr Glu Tyr Leu Lys Gln Lys Ile His Asp Leu Glu
1105                1110                1115                1120
Thr Glu Leu Glu Gly Tyr Gln Asn Phe Ile Phe Gln Leu Gln Lys His
                1125                1130                1135    
Ser Gln Cys Ser Glu Ala Ile Ile Thr Val Leu Cys Gly Thr Glu Gly
            1140                1145                1150        
Ala Gln Asp Gly Leu Ser Lys Pro Lys Asn Gly Ser Asp Gly Glu Glu
        1155                1160                1165            
Met Thr Phe Ser Ser Leu His Gln Val Arg Tyr Val Lys His Val Lys
    1170                1175                1180                
Ile Leu Gly Pro Leu Ala Pro Glu Met Ile Asp Ser Arg Val Leu Glu
1185                1190                1195                1200
Asn Leu Lys Gln Gln Leu Glu Glu Gln Glu Tyr Lys Leu Gln Lys Glu
                1205                1210                1215    
Gln Asn Leu Asn Met Gln Leu Phe Ser Glu Ile His Asn Leu Gln Asn
            1220                1225                1230        
Lys Phe Arg Asp Leu Ser Pro Pro Arg Tyr Asp Ser Leu Val Gln Ser
        1235                1240                1245            
Gln Ala Arg Glu Leu Ser Leu Gln Arg Gln Gln Ile Lys Asp Gly His
    1250                1255                1260                
Gly Ile Cys Val Ile Ser Arg Gln His Met Asn Thr Met Ile Lys Ala
1265                1270                1275                1280
Phe Glu Glu Leu Leu Gln Ala Ser Asp Val Asp Tyr Cys Val Ala Glu
                1285                1290                1295    
Gly Phe Gln Glu Gln Leu Asn Gln Cys Ala Glu Leu Leu Glu Lys Leu
            1300                1305                1310        
Glu Lys Leu Phe Leu Asn Gly Lys Ser Val Gly Val Glu Met Asn Thr
        1315                1320                1325            
Gln Asn Glu Leu Met Glu Arg Ile Glu Glu Asp Asn Leu Thr Tyr Gln
    1330                1335                1340                
His Leu Leu Pro Glu Ser Pro Glu Pro Ser Ala Ser His Ala Leu Ser
1345                1350                1355                1360
Asp Tyr Glu Thr Ser Glu Lys Ser Phe Phe Ser Arg Asp Gln Lys Gln
                1365                1370                1375    
Asp Asn Glu Thr Glu Lys Thr Ser Val Met Val Asn Ser Phe Ser Gln
            1380                1385                1390        
Asp Leu Leu Met Glu His Ile Gln Glu Ile Arg Thr Leu Arg Lys Arg
        1395                1400                1405            
Leu Glu Glu Ser Ile Lys Thr Asn Glu Lys Leu Arg Lys Gln Leu Glu
    1410                1415                1420                
Arg Gln Gly Ser Glu Phe Val Gln Gly Ser Thr Ser Ile Phe Ala Ser
1425                1430                1435                1440
Gly Ser Glu Leu His Ser Ser Leu Thr Ser Glu Ile His Phe Leu Arg
                1445                1450                1455    
Lys Gln Asn Gln Ala Leu Asn Ala Met Leu Ile Lys Gly Ser Arg Asp
            1460                1465                1470        
Lys Gln Lys Glu Asn Asp Lys Leu Arg Glu Ser Leu Ser Arg Lys Thr
        1475                1480                1485            
Val Ser Leu Glu His Leu Gln Arg Glu Tyr Ala Ser Val Lys Glu Glu
    1490                1495                1500                
Asn Glu Arg Leu Gln Lys Glu Gly Ser Glu Lys Glu Arg His Asn Gln
1505                1510                1515                1520
Gln Leu Ile Gln Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Arg Val
                1525                1530                1535    
Gln Glu Glu Leu Lys Leu Arg Gln Gln Leu Leu Ser Gln Asn Asp Lys
            1540                1545                1550        
Leu Leu Gln Ser Leu Arg Val Glu Leu Lys Ala Tyr Glu Lys Leu Asp
        1555                1560                1565            
Glu Glu His Arg Arg Leu Arg Asp Gly Asp Lys Tyr Pro Met Glu Ser
    1570                1575                1580                
Asp Asn Ser Phe Asp Leu Phe Asp Ser Ser Gln Ala Val Thr Pro Lys
1585                1590                1595                1600
Ser Val Ser Glu Thr Pro Pro Leu Ser Gly Asn Asp Thr Asp Ser Leu
                1605                1610                1615    
Ser Cys Asp Ser Gly Ser Ser Ala Thr Ser Thr Pro Cys Val Ser Arg
            1620                1625                1630        
Leu Val Thr Gly His His Leu Trp Ala Ser Lys Asn Gly Arg His Val
        1635                1640                1645            
Leu Gly Leu Ile Glu Asp Tyr Glu Ala Leu Leu Lys Gln Ile Ser Gln
    1650                1655                1660                
Gly Gln Arg Leu Leu Ala Glu Met Asp Ile Gln Thr Gln Glu Ala Pro
1665                1670                1675                1680
Ser Ser Thr Ser Gln Glu Leu Gly Thr Lys Gly Pro His Pro Ala Pro
                1685                1690                1695    
Leu Ser Lys Phe Val Ser Ser Val Ser Thr Ala Lys Leu Thr Leu Glu
            1700                1705                1710        
Glu Ala Tyr Arg Arg Leu Lys Leu Leu Trp Arg Val Ser Leu Pro Glu
        1715                1720                1725            
Asp Gly Gln Cys Pro Leu His Cys Glu Gln Ile Gly Glu Met Lys Ala
    1730                1735                1740                
Glu Val Thr Lys Leu His Lys Lys Leu Phe Glu Gln Glu Lys Lys Leu
1745                1750                1755                1760
Gln Asn Thr Met Lys Leu Leu Gln Leu Ser Lys Arg Gln Glu Lys Val
                1765                1770                1775    
Ile Phe Asp Gln Leu Val Val Thr His Lys Ile Leu Arg Lys Ala Arg
            1780                1785                1790        
Gly Asn Leu Glu Leu Arg Pro Gly Gly Ala His Pro Gly Thr Cys Ser
        1795                1800                1805            
Pro Ser Arg Pro Gly Ser
    1810                


<210> 6320
<211> 792
<212> PRT
<213> Homo sapiens

<400> 6320
His Leu Gly Asp Leu Leu His Lys Leu Gln Phe Val Leu Thr Thr Arg
 1               5                  10                  15      
Arg Val Asp Asn Ser Asn Thr Arg Leu Ala Val Gln Ile Glu Arg Asp
            20                  25                  30          
Pro Gly Asn Asp Asp Asn Asn Leu Asn Ser Ile Phe Tyr Glu His Leu
        35                  40                  45              
Thr Arg Thr Leu Gln Glu Ser Leu Cys Gly Asp Leu Val Leu Gly Arg
    50                  55                  60                  
Trp Gly Asn Tyr Ser Ser Gly Asp Cys Phe Ile Leu Ala Ser Asp Asp
65                  70                  75                  80  
Leu Asn Ala Phe Val His Leu Ile Glu Ile Gly Asn Gly Leu Val Thr
                85                  90                  95      
Phe Gln Leu Arg Gly Leu Glu Phe Arg Gly Thr Tyr Cys Gln Gln Arg
            100                 105                 110         
Glu Val Glu Ala Ile Met Glu Gly Asp Glu Glu Asp Arg Gly Cys Cys
        115                 120                 125             
Cys Cys Lys Pro Gly His Leu Pro His Leu Leu Ser Cys Asn Ala Ala
    130                 135                 140                 
Phe His Leu Arg Trp Leu Thr Trp Glu Ile Thr Gln Thr Gln Tyr Ile
145                 150                 155                 160 
Leu Glu Gly Tyr Ser Ile Leu Asp Asn Asn Ala Ala Thr Met Leu Gln
                165                 170                 175     
Val Phe Asp Leu Arg Arg Ile Leu Ile Arg Tyr Tyr Ile Lys Ser Ile
            180                 185                 190         
Ile Tyr Tyr Met Val Thr Ser Pro Lys Leu Leu Ser Trp Ile Lys Asn
        195                 200                 205             
Glu Ser Leu Leu Lys Ser Leu Gln Pro Phe Ala Lys Trp His Tyr Ile
    210                 215                 220                 
Glu Arg Asp Leu Ala Met Phe Asn Ile Asn Ile Asp Asp Asp Tyr Val
225                 230                 235                 240 
Pro Cys Leu Gln Gly Ile Thr Arg Ala Ser Phe Cys Asn Val Tyr Leu
                245                 250                 255     
Glu Trp Ile Gln His Cys Ala Arg Lys Arg Gln Glu Pro Ser Thr Thr
            260                 265                 270         
Leu Asp Ser Asp Glu Asp Ser Pro Leu Val Thr Leu Ser Phe Ala Leu
        275                 280                 285             
Cys Thr Leu Gly Arg Arg Ala Leu Gly Thr Ala Ala His Asn Met Ala
    290                 295                 300                 
Ile Ser Leu Asp Ser Phe Leu Tyr Gly Leu His Val Leu Phe Lys Gly
305                 310                 315                 320 
Asp Phe Arg Ile Thr Ala Arg Asp Glu Trp Val Phe Ala Asp Met Asp
                325                 330                 335     
Leu Leu His Lys Val Val Ala Pro Ala Ile Arg Met Ser Leu Lys Leu
            340                 345                 350         
His Gln Asp Gln Phe Thr Cys Pro Asp Glu Tyr Glu Asp Pro Ala Val
        355                 360                 365             
Leu Tyr Glu Ala Ile Gln Ser Phe Glu Lys Lys Val Val Ile Cys His
    370                 375                 380                 
Glu Gly Asp Pro Ala Trp Arg Gly Ala Val Leu Ser Asn Lys Glu Glu
385                 390                 395                 400 
Leu Leu Thr Leu Arg His Val Val Asp Glu Gly Ala Asp Glu Tyr Lys
                405                 410                 415     
Val Ile Met Leu His Arg Ser Phe Leu Ser Phe Lys Val Ile Lys Val
            420                 425                 430         
Asn Lys Glu Cys Val Arg Gly Leu Trp Ala Gly Gln Gln Gln Glu Leu
        435                 440                 445             
Ile Phe Leu Arg Asn Arg Asn Pro Glu Arg Gly Ser Ile Gln Asn Asn
    450                 455                 460                 
Lys Gln Val Leu Arg Asn Leu Ile Asn Ser Ser Cys Asp Gln Pro Leu
465                 470                 475                 480 
Gly Tyr Pro Met Tyr Val Ser Pro Leu Thr Thr Ser Tyr Leu Gly Thr
                485                 490                 495     
His Arg Gln Leu Lys Asn Ile Trp Gly Gly Pro Ile Thr Leu Asp Arg
            500                 505                 510         
Ile Arg Thr Trp Phe Trp Thr Lys Trp Val Arg Met Arg Lys Asp Cys
        515                 520                 525             
Asn Ala Arg Gln His Ser Gly Gly Asn Ile Glu Asp Val Asp Gly Gly
    530                 535                 540                 
Gly Ala Pro Thr Thr Gly Gly Asn Asn Ala Pro Ser Gly Gly Ser Gln
545                 550                 555                 560 
Glu Ser Ser Ala Glu Gln Pro Arg Lys Gly Gly Ala Gln His Gly Val
                565                 570                 575     
Ser Ser Cys Glu Gly Thr Gln Arg Thr Gly Arg Arg Lys Gly Arg Ser
            580                 585                 590         
Gln Ser Val Gln Ala His Ser Ala Leu Ser Gln Arg Pro Pro Met Leu
        595                 600                 605             
Ser Ser Ser Gly Pro Ile Leu Glu Ser Arg Gln Thr Phe Leu Gln Thr
    610                 615                 620                 
Ser Thr Ser Val His Glu Leu Ala Gln Arg Leu Ser Gly Ser Arg Leu
625                 630                 635                 640 
Ser Leu His Ala Ser Ala Thr Ser Leu His Ser Gln Pro Pro Pro Val
                645                 650                 655     
Thr Thr Thr Gly His Leu Ser Val Arg Glu Arg Ala Glu Ala Leu Ile
            660                 665                 670         
Arg Ser Ser Leu Gly Ser Ser Thr Ser Ser Thr Leu Ser Phe Leu Phe
        675                 680                 685             
Gly Lys Arg Ser Phe Ser Ser Ala Leu Val Ile Ser Gly Leu Ser Ala
    690                 695                 700                 
Ala Glu Gly Gly Asn Thr Ser Asp Thr Gln Ser Ser Ser Ser Val Asn
705                 710                 715                 720 
Ile Val Met Gly Pro Ser Ala Arg Ala Ala Ser Gln Ala Thr Arg His
                725                 730                 735     
Leu Ser Glu Pro Cys Glu Pro Pro Asp Ala Thr Glu Gln Gly Gln Leu
            740                 745                 750         
His Asp Arg Cys Leu Ala Glu Ala Val Ala Asp Thr Leu Gly Val Val
        755                 760                 765             
Cys Arg Arg Ala Ser Gln Glu Asp Met Gly Leu Asp Asp Thr Ala Ser
    770                 775                 780                 
Gln Gln Ser Val Ser Asp Glu Gln
785                 790         


<210> 6321
<211> 777
<212> PRT
<213> Homo sapiens

<400> 6321
Met Thr Phe Tyr Pro Phe Val Ala Ser Ser Ser Thr Arg Arg Val Asp
 1               5                  10                  15      
Asn Ser Asn Thr Arg Leu Ala Val Gln Ile Glu Arg Asp Pro Gly Asn
            20                  25                  30          
Asp Asp Asn Asn Leu Asn Ser Ile Phe Tyr Glu His Leu Thr Arg Thr
        35                  40                  45              
Leu Gln Glu Ser Leu Cys Gly Asp Leu Val Leu Gly Arg Trp Gly Asn
    50                  55                  60                  
Tyr Ser Ser Gly Asp Cys Phe Ile Leu Ala Ser Asp Asp Leu Asn Ala
65                  70                  75                  80  
Phe Val His Leu Ile Glu Ile Gly Asn Gly Leu Val Thr Phe Gln Leu
                85                  90                  95      
Arg Gly Leu Glu Phe Arg Gly Thr Tyr Cys Gln Gln Arg Glu Val Glu
            100                 105                 110         
Ala Ile Met Glu Gly Asp Glu Glu Asp Arg Gly Cys Cys Cys Cys Lys
        115                 120                 125             
Pro Gly His Leu Pro His Leu Leu Ser Cys Asn Ala Ala Phe His Leu
    130                 135                 140                 
Arg Trp Leu Thr Trp Glu Ile Thr Gln Thr Gln Tyr Ile Leu Glu Gly
145                 150                 155                 160 
Tyr Ser Ile Leu Asp Asn Asn Ala Ala Thr Met Leu Gln Val Phe Asp
                165                 170                 175     
Leu Arg Arg Ile Leu Ile Arg Tyr Tyr Ile Lys Ser Ile Ile Tyr Tyr
            180                 185                 190         
Met Val Thr Ser Pro Lys Leu Leu Ser Trp Ile Lys Asn Glu Ser Leu
        195                 200                 205             
Leu Lys Ser Leu Gln Pro Phe Ala Lys Trp His Tyr Ile Glu Arg Asp
    210                 215                 220                 
Leu Ala Met Phe Asn Ile Asn Ile Asp Asp Asp Tyr Val Pro Cys Leu
225                 230                 235                 240 
Gln Gly Ile Thr Arg Ala Ser Phe Cys Asn Val Tyr Leu Glu Trp Ile
                245                 250                 255     
Gln His Cys Ala Arg Lys Arg Gln Glu Pro Ser Thr Thr Leu Asp Ser
            260                 265                 270         
Asp Glu Asp Ser Pro Leu Val Thr Leu Ser Phe Ala Leu Cys Thr Leu
        275                 280                 285             
Gly Arg Arg Ala Leu Gly Thr Ala Ala His Asn Met Ala Ile Ser Leu
    290                 295                 300                 
Asp Ser Phe Leu Tyr Gly Leu His Val Leu Phe Lys Gly Asp Phe Arg
305                 310                 315                 320 
Ile Thr Ala Arg Asp Glu Trp Val Phe Ala Asp Met Asp Leu Leu His
                325                 330                 335     
Lys Val Val Ala Pro Ala Ile Arg Met Ser Leu Lys Leu His Gln Asp
            340                 345                 350         
Gln Phe Thr Cys Pro Asp Glu Tyr Glu Asp Pro Ala Val Leu Tyr Glu
        355                 360                 365             
Ala Ile Gln Ser Phe Glu Lys Lys Val Val Ile Cys His Glu Gly Asp
    370                 375                 380                 
Pro Ala Trp Arg Gly Ala Val Leu Ser Asn Lys Glu Glu Leu Leu Thr
385                 390                 395                 400 
Leu Arg His Val Val Asp Glu Gly Ala Asp Glu Tyr Lys Val Ile Met
                405                 410                 415     
Leu His Arg Ser Phe Leu Ser Phe Lys Val Ile Lys Val Asn Lys Glu
            420                 425                 430         
Cys Val Arg Gly Leu Trp Ala Gly Gln Gln Gln Glu Leu Ile Phe Leu
        435                 440                 445             
Arg Asn Arg Asn Pro Glu Arg Gly Ser Ile Gln Asn Asn Lys Gln Val
    450                 455                 460                 
Leu Arg Asn Leu Ile Asn Ser Ser Cys Asp Gln Pro Leu Gly Tyr Pro
465                 470                 475                 480 
Met Tyr Val Ser Pro Leu Thr Thr Ser Tyr Leu Gly Thr His Arg Gln
                485                 490                 495     
Leu Lys Asn Ile Trp Gly Gly Pro Ile Thr Leu Asp Arg Ile Arg Thr
            500                 505                 510         
Trp Phe Trp Thr Lys Trp Val Arg Met Arg Lys Asp Cys Asn Ala Arg
        515                 520                 525             
Gln His Ser Gly Gly Asn Ile Glu Asp Val Asp Gly Gly Gly Ala Pro
    530                 535                 540                 
Thr Thr Gly Gly Asn Asn Ala Pro Asn Gly Gly Ser Gln Glu Ser Ser
545                 550                 555                 560 
Ala Glu Gln Pro Arg Lys Gly Gly Ala Gln His Gly Val Ser Ser Cys
                565                 570                 575     
Glu Gly Thr Gln Arg Thr Gly Arg Arg Lys Gly Arg Ser Gln Ser Val
            580                 585                 590         
Gln Ala His Ser Ala Leu Ser Gln Arg Pro Pro Met Leu Ser Ser Ser
        595                 600                 605             
Gly Pro Ile Leu Glu Ser Arg Gln Thr Phe Leu Gln Thr Ser Thr Ser
    610                 615                 620                 
Val His Glu Leu Ala Gln Arg Leu Ser Gly Ser Arg Leu Ser Leu His
625                 630                 635                 640 
Ala Ser Ala Thr Ser Leu His Ser Gln Pro Pro Pro Val Thr Thr Thr
                645                 650                 655     
Gly His Leu Ser Val Arg Glu Arg Ala Glu Ala Leu Ile Arg Ser Ser
            660                 665                 670         
Leu Gly Ser Ser Thr Ser Ser Thr Leu Ser Phe Leu Phe Gly Lys Arg
        675                 680                 685             
Ser Phe Ser Ser Ala Leu Val Ile Ser Gly Leu Ser Ala Ala Glu Gly
    690                 695                 700                 
Gly Asn Thr Ser Asp Thr Gln Ser Ser Ser Ser Val Asn Ile Val Met
705                 710                 715                 720 
Gly Pro Ser Ala Arg Ala Ala Ser Gln Ala Thr Arg Val Arg Gly Trp
                725                 730                 735     
Ala Gly Leu Thr Arg Thr Gly Trp Asp Gly Gly Thr Gly Ser Trp Pro
            740                 745                 750         
Glu Arg Gly Thr Cys Leu Ala Phe Pro Pro Phe Cys Leu Gln Asn Pro
        755                 760                 765             
Ile Pro Phe Ser Met Gly Leu Pro Glu
    770                 775         


<210> 6322
<211> 399
<212> PRT
<213> Homo sapiens

<400> 6322
Met Tyr Ser Pro Arg Gly Ser Gln Gly Arg Gly Thr Ala Glu Ala Thr
 1               5                  10                  15      
Ala Asn Ser Pro Ser Pro Pro Ile Ala Pro Ser His Ser Arg Val Thr
            20                  25                  30          
Phe Ser Leu Ser Thr Leu His Thr Leu Ser Pro Pro Pro Arg Pro Phe
        35                  40                  45              
Pro Ser Val Ser Arg Ala Ala Ala Gln Lys Pro His His Leu His Pro
    50                  55                  60                  
His Ile Leu Leu Ala Gly Ser Ala Ala Val Pro Pro Arg Val Leu Lys
65                  70                  75                  80  
Ala Glu Met Asn Asn Thr Ala Ala Ser Pro Met Ser Thr Ala Thr Ser
                85                  90                  95      
Ser Ser Gly Arg Ser Thr Gly Lys Ser Ile Ser Phe Ala Thr Glu Leu
            100                 105                 110         
Gln Ser Met Met Tyr Ser Leu Gly Asp Ala Arg Arg Pro Leu His Glu
        115                 120                 125             
Thr Ala Val Leu Val Glu Asp Val Val His Thr Gln Leu Ile Asn Leu
    130                 135                 140                 
Leu Gln Gln Ala Ala Glu Val Ser Gln Leu Arg Gly Ala Arg Val Ile
145                 150                 155                 160 
Thr Pro Glu Asp Leu Leu Phe Leu Met Arg Lys Asp Lys Lys Lys Leu
                165                 170                 175     
Arg Arg Leu Leu Lys Tyr Met Phe Ile Arg Asp Tyr Lys Ser Lys Ile
            180                 185                 190         
Val Lys Gly Ile Asp Glu Asp Asp Leu Leu Glu Asp Lys Leu Ser Gly
        195                 200                 205             
Ser Asn Asn Ala Asn Lys Arg Gln Lys Ile Ala Gln Asp Phe Leu Asn
    210                 215                 220                 
Ser Ile Asp Gln Thr Gly Glu Leu Leu Ala Met Phe Glu Asp Asp Glu
225                 230                 235                 240 
Ile Asp Glu Val Lys Gln Glu Arg Met Glu Arg Ala Glu Arg Gln Thr
                245                 250                 255     
Arg Ile Met Asp Ser Ala Gln Tyr Ala Glu Phe Cys Glu Ser Arg Gln
            260                 265                 270         
Leu Ser Phe Ser Lys Lys Ala Ser Lys Phe Arg Asp Trp Leu Asp Cys
        275                 280                 285             
Ser Ser Met Glu Ile Lys Pro Asn Val Val Ala Met Glu Ile Leu Ala
    290                 295                 300                 
Tyr Leu Ala Tyr Glu Thr Val Ala Gln Leu Val Asp Leu Ala Leu Leu
305                 310                 315                 320 
Val Arg Gln Asp Met Val Thr Lys Ala Gly Asp Pro Phe Ser His Ala
                325                 330                 335     
Ile Ser Ala Thr Phe Ile Gln Tyr His Asn Ser Ala Glu Ser Thr Ala
            340                 345                 350         
Ala Cys Gly Val Glu Ala His Ser Asp Ala Ile Gln Pro Cys His Ile
        355                 360                 365             
Arg Glu Ala Ile Arg Arg Tyr Ser His Arg Ile Gly Pro Leu Ser Pro
    370                 375                 380                 
Phe Thr Asn Ala Tyr Arg Arg Asn Gly Met Ala Phe Leu Ala Cys
385                 390                 395                 


<210> 6323
<211> 317
<212> PRT
<213> Homo sapiens

<400> 6323
Met Asn Asn Thr Ala Ala Ser Pro Met Ser Thr Ala Thr Ser Ser Ser
 1               5                  10                  15      
Gly Arg Ser Thr Gly Lys Ser Ile Ser Phe Ala Thr Glu Leu Gln Ser
            20                  25                  30          
Met Met Tyr Ser Leu Gly Asp Ala Arg Arg Pro Leu His Glu Thr Ala
        35                  40                  45              
Val Leu Val Glu Asp Val Val His Thr Gln Leu Ile Asn Leu Leu Gln
    50                  55                  60                  
Gln Ala Ala Glu Val Ser Gln Leu Arg Gly Ala Arg Val Ile Thr Pro
65                  70                  75                  80  
Glu Asp Leu Leu Phe Leu Met Arg Lys Asp Lys Lys Lys Leu Arg Arg
                85                  90                  95      
Leu Leu Lys Tyr Met Phe Ile Arg Asp Tyr Lys Ser Lys Ile Val Lys
            100                 105                 110         
Gly Ile Asp Glu Asp Asp Leu Leu Glu Asp Lys Leu Ser Gly Ser Asn
        115                 120                 125             
Asn Ala Asn Lys Arg Gln Lys Ile Ala Gln Asp Phe Leu Asn Ser Ile
    130                 135                 140                 
Asp Gln Thr Gly Glu Leu Leu Ala Met Phe Glu Asp Asp Glu Ile Asp
145                 150                 155                 160 
Glu Val Lys Gln Glu Arg Met Glu Arg Ala Glu Arg Gln Thr Arg Ile
                165                 170                 175     
Met Asp Ser Ala Gln Tyr Ala Glu Phe Cys Glu Ser Arg Gln Leu Ser
            180                 185                 190         
Phe Ser Lys Lys Ala Ser Lys Phe Arg Asp Trp Leu Asp Cys Ser Ser
        195                 200                 205             
Met Glu Ile Lys Pro Asn Val Val Ala Met Glu Ile Leu Ala Tyr Leu
    210                 215                 220                 
Ala Tyr Glu Thr Val Ala Gln Leu Val Asp Leu Ala Leu Leu Val Arg
225                 230                 235                 240 
Gln Asp Met Val Thr Lys Ala Gly Asp Pro Phe Ser His Ala Ile Ser
                245                 250                 255     
Ala Thr Phe Ile Gln Tyr His Asn Ser Ala Glu Ser Thr Ala Ala Cys
            260                 265                 270         
Gly Val Glu Ala His Ser Asp Ala Ile Gln Pro Cys His Ile Arg Glu
        275                 280                 285             
Ala Ile Arg Arg Tyr Ser His Arg Ile Gly Pro Leu Ser Pro Phe Thr
    290                 295                 300                 
Asn Ala Tyr Arg Arg Asn Gly Met Ala Phe Leu Ala Cys
305                 310                 315         


<210> 6324
<211> 96
<212> PRT
<213> Homo sapiens

<400> 6324
Ser Cys Thr Pro Pro Ile Ala Pro Ser His Ser Arg Val Thr Phe Ser
 1               5                  10                  15      
Leu Ser Thr Leu His Thr Leu Ser Pro Pro Pro Arg Pro Phe Pro Ser
            20                  25                  30          
Val Ser Arg Ala Ala Gln Lys Pro His His Leu His Pro His Ile Leu
        35                  40                  45              
Leu Ala Gly Ser Ala Ala Val Pro Pro Arg Val Leu Lys Ala Glu Met
    50                  55                  60                  
Asn Asn Thr Ala Ala Ser Pro Met Ser Thr Ala Thr Ser Ser Ser Gly
65                  70                  75                  80  
Arg Ser Thr Gly Lys Ser Ile Ser Phe Ala Thr Glu Leu Gln Ser Met
                85                  90                  95      


<210> 6325
<211> 531
<212> PRT
<213> Homo sapiens

<400> 6325
Met Asp Ser Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu
 1               5                  10                  15      
Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Asn Leu Tyr Arg Glu Val
            20                  25                  30          
Met Gln Glu Thr Leu Arg Asn Leu Thr Ser Ile Gly Lys Lys Trp Asn
        35                  40                  45              
Asn Gln Tyr Ile Glu Asp Glu His Gln Asn Pro Arg Arg Asn Leu Arg
    50                  55                  60                  
Arg Leu Ile Gly Glu Arg Leu Ser Glu Ser Lys Glu Ser His Gln His
65                  70                  75                  80  
Gly Glu Val Leu Thr Gln Val Pro Asp Asp Thr Leu Lys Lys Lys Thr
                85                  90                  95      
Pro Gly Val Gln Ser Tyr Glu Ser Ser Val Cys Gly Glu Ile Gly Ile
            100                 105                 110         
Gly Leu Ser Ser Leu Asn Arg His Leu Arg Ala Phe Ser Tyr Ser Ser
        115                 120                 125             
Ser Leu Ala Ile His Gly Arg Thr His Thr Gly Glu Lys Pro Tyr Glu
    130                 135                 140                 
Cys Lys Glu Cys Gly Lys Ala Phe Arg Phe Pro Ser Ser Val Arg Arg
145                 150                 155                 160 
His Glu Arg Ile His Ser Ala Lys Lys Pro Tyr Glu Cys Lys Gln Cys
                165                 170                 175     
Gly Lys Ala Phe Ser Phe Pro Ser Ser Val Arg Arg His Glu Arg Ile
            180                 185                 190         
His Ser Ala Lys Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Leu
        195                 200                 205             
Ser Tyr Leu Val Ser Phe Gln Thr His Met Arg Met His Thr Gly Glu
    210                 215                 220                 
Arg Pro His Lys Cys Asn Ile Cys Gly Lys Ala Phe Phe Ser Pro Ser
225                 230                 235                 240 
Ser Leu Lys Arg His Glu Lys Ser His Thr Gly Glu Lys Arg Tyr Lys
                245                 250                 255     
Cys Lys Gln Cys Asp Lys Ala Phe Asn Cys Pro Ser Ser Phe Gln Tyr
            260                 265                 270         
His Glu Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys Thr Gln Cys
        275                 280                 285             
Arg Lys Ala Phe Arg Ser Val Lys Tyr Leu Arg Val His Glu Arg Lys
    290                 295                 300                 
His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Leu Cys Gly Lys Gly Phe
305                 310                 315                 320 
Ile Ser Ser Thr Ser Phe Arg Tyr His Glu Lys Thr His Thr Gly Glu
                325                 330                 335     
Lys Pro Tyr Glu Cys Lys Lys Cys Val Lys Ala Phe Ser Phe Val Lys
            340                 345                 350         
Asp Leu Arg Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Phe Glu
        355                 360                 365             
Cys Lys Gln Cys Gly Lys Thr Phe Thr Ser Ser Asn Ser Phe His Tyr
    370                 375                 380                 
His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys
385                 390                 395                 400 
Gly Lys Ala Phe Arg Ser Ala Ser Val Leu Gln Lys His Ile Arg Thr
                405                 410                 415     
His Thr Gly Glu Lys Pro Tyr Gly Cys Lys Gln Cys Gly Lys Val Phe
            420                 425                 430         
Arg Val Ala Ser Gln Leu Lys Met His Glu Arg Thr His Thr Gly Glu
        435                 440                 445             
Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ile Ser Ser Asn
    450                 455                 460                 
Ser Ile Arg Tyr His Lys Arg Thr His Thr Gly Glu Lys Pro Tyr Lys
465                 470                 475                 480 
Cys Lys Gln Cys Gly Lys Ala Phe Ile Ser Ser Asn Ser Phe Leu Tyr
                485                 490                 495     
His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys
            500                 505                 510         
Gly Lys Ala Phe Arg Ser Ala Ser Ile Leu Gln Lys His Val Arg Thr
        515                 520                 525             
His Ala Gly
    530     


<210> 6326
<211> 123
<212> PRT
<213> Homo sapiens

<400> 6326
Met Ala Leu Asn Asn Val Ser Leu Ser Ser Gly Asp Gln Arg Ser Arg
 1               5                  10                  15      
Val Ala Tyr Arg Ser Ser His Gly Asp Leu Arg Pro Arg Ala Ser Ala
            20                  25                  30          
Leu Ala Met Val Ser Gly Asp Gly Phe Leu Val Ser Arg Pro Glu Ala
        35                  40                  45              
Ile His Leu Gly Pro Arg Gln Ala Val Arg Pro Ser Val Arg Ala Glu
    50                  55                  60                  
Ser Arg Arg Val Asp Gly Gly Gly Arg Ser Pro Arg Glu Pro Asp Gly
65                  70                  75                  80  
Arg Gly Arg Ser Arg Gln Ala Arg Phe Ser Pro Tyr Pro Ile Pro Ala
                85                  90                  95      
Val Glu Pro Asp Leu Leu Arg Ser Val Leu Gln Gln Arg Leu Ile Ala
            100                 105                 110         
Leu Gly Gly Val Ile Ala Ala Arg Ile Ser Val
        115                 120             


<210> 6327
<211> 126
<212> PRT
<213> Homo sapiens

<400> 6327
Met Ala Glu Ala Gly Ala Gly Leu Ser Glu Thr Val Thr Glu Thr Thr
 1               5                  10                  15      
Val Thr Val Thr Thr Glu Pro Glu Asn Arg Ser Leu Thr Ile Lys Leu
            20                  25                  30          
Arg Lys Arg Lys Pro Glu Lys Lys Val Glu Trp Thr Ser Asp Thr Val
        35                  40                  45              
Asp Asn Glu His Met Gly Arg Arg Ser Ser Lys Cys Cys Cys Ile Tyr
    50                  55                  60                  
Glu Lys Pro Arg Ala Phe Gly Glu Ser Ser Thr Glu Ser Asp Glu Glu
65                  70                  75                  80  
Glu Glu Glu Gly Cys Gly His Thr His Cys Val Arg Gly His Arg Lys
                85                  90                  95      
Gly Arg Arg Arg Ala Thr Leu Gly Pro Thr Pro Thr Thr Pro Pro Gln
            100                 105                 110         
Pro Pro Asp Pro Ser Gln Pro Pro Pro Gly Pro Met Gln His
        115                 120                 125     


<210> 6328
<211> 916
<212> PRT
<213> Homo sapiens

<400> 6328
Met Thr Ala Gly Ala Gly Val Leu Leu Leu Leu Leu Ser Leu Ser Gly
 1               5                  10                  15      
Ala Leu Arg Ala His Asn Glu Asp Leu Thr Thr Arg Glu Thr Cys Lys
            20                  25                  30          
Ala Gly Phe Ser Glu Asp Asp Tyr Thr Ala Leu Ile Ser Gln Asn Ile
        35                  40                  45              
Leu Glu Gly Glu Lys Leu Leu Gln Val Lys Phe Ser Ser Cys Val Gly
    50                  55                  60                  
Thr Lys Gly Thr Gln Tyr Glu Thr Asn Ser Met Asp Phe Lys Val Gly
65                  70                  75                  80  
Ala Asp Gly Thr Val Phe Ala Thr Arg Glu Leu Gln Val Pro Ser Glu
                85                  90                  95      
Gln Val Ala Phe Thr Val Thr Ala Trp Asp Ser Gln Thr Ala Glu Lys
            100                 105                 110         
Trp Asp Ala Val Val Arg Leu Leu Val Ala Gln Thr Ser Ser Pro His
        115                 120                 125             
Ser Gly His Lys Pro Gln Lys Gly Lys Lys Val Val Ala Leu Asp Pro
    130                 135                 140                 
Ser Pro Pro Pro Lys Asp Thr Leu Leu Pro Trp Pro Gln His Gln Asn
145                 150                 155                 160 
Ala Asn Gly Leu Arg Arg Arg Lys Arg Asp Trp Val Ile Pro Pro Ile
                165                 170                 175     
Asn Val Pro Glu Asn Ser Arg Gly Pro Phe Pro Gln Gln Leu Val Arg
            180                 185                 190         
Ile Arg Ser Asp Lys Asp Asn Asp Ile Pro Ile Arg Tyr Ser Ile Thr
        195                 200                 205             
Gly Val Gly Ala Asp Gln Pro Pro Met Glu Val Phe Ser Ile Asp Ser
    210                 215                 220                 
Met Ser Gly Arg Met Tyr Val Thr Arg Pro Met Asp Arg Glu Glu His
225                 230                 235                 240 
Ala Ser Tyr His Leu Arg Ala His Ala Val Asp Met Asn Gly Asn Lys
                245                 250                 255     
Val Glu Asn Pro Ile Asp Leu Tyr Ile Tyr Val Ile Asp Met Asn Asp
            260                 265                 270         
Asn Arg Pro Glu Phe Ile Asn Gln Val Tyr Asn Gly Ser Val Asp Glu
        275                 280                 285             
Gly Ser Lys Pro Gly Thr Tyr Val Met Thr Val Thr Ala Asn Asp Ala
    290                 295                 300                 
Asp Asp Ser Thr Thr Ala Asn Gly Met Val Arg Tyr Arg Ile Val Thr
305                 310                 315                 320 
Gln Thr Pro Gln Ser Pro Ser Gln Asn Met Phe Thr Ile Asn Ser Glu
                325                 330                 335     
Thr Gly Asp Ile Val Thr Val Ala Ala Gly Leu Asp Arg Glu Lys Val
            340                 345                 350         
Gln Gln Tyr Thr Val Ile Val Gln Ala Thr Asp Met Glu Gly Asn Leu
        355                 360                 365             
Asn Tyr Gly Leu Ser Asn Thr Ala Thr Ala Ile Ile Thr Val Thr Asp
    370                 375                 380                 
Val Asn Asp Asn Pro Pro Glu Phe Thr Ala Ser Thr Phe Ala Gly Glu
385                 390                 395                 400 
Val Pro Glu Asn Arg Val Glu Thr Val Val Ala Asn Leu Thr Val Met
                405                 410                 415     
Asp Arg Asp Gln Pro His Ser Pro Asn Trp Asn Ala Val Tyr Arg Ile
            420                 425                 430         
Ile Ser Gly Asp Pro Ser Gly His Phe Ser Val Arg Thr Asp Pro Val
        435                 440                 445             
Thr Asn Glu Gly Met Val Thr Val Val Lys Ala Val Asp Tyr Glu Leu
    450                 455                 460                 
Asn Arg Ala Phe Met Leu Thr Val Met Val Ser Asn Gln Ala Pro Leu
465                 470                 475                 480 
Ala Ser Gly Ile Gln Met Ser Phe Gln Ser Thr Ala Gly Val Thr Ile
                485                 490                 495     
Ser Ile Met Asp Ile Asn Glu Ala Pro Tyr Phe Pro Ser Asn His Lys
            500                 505                 510         
Leu Ile Arg Leu Glu Glu Gly Val Pro Pro Gly Thr Val Leu Thr Thr
        515                 520                 525             
Phe Ser Ala Val Asp Pro Asp Arg Phe Met Gln Gln Ala Val Arg Tyr
    530                 535                 540                 
Ser Lys Leu Ser Asp Pro Ala Ser Trp Leu His Ile Asn Ala Thr Asn
545                 550                 555                 560 
Gly Gln Ile Thr Thr Ala Ala Val Leu Asp Arg Glu Ser Leu Tyr Thr
                565                 570                 575     
Lys Asn Asn Val Tyr Glu Ala Thr Phe Leu Ala Ala Asp Asn Gly Ile
            580                 585                 590         
Pro Pro Ala Ser Gly Thr Gly Thr Leu Gln Ile Tyr Leu Ile Asp Ile
        595                 600                 605             
Asn Asp Asn Ala Pro Glu Leu Leu Pro Lys Glu Ala Gln Ile Cys Glu
    610                 615                 620                 
Lys Pro Asn Leu Asn Ala Ile Asn Ile Thr Ala Ala Asp Ala Asp Val
625                 630                 635                 640 
Asp Pro Asn Ile Gly Pro Tyr Val Phe Glu Leu Pro Phe Val Pro Ala
                645                 650                 655     
Ala Val Arg Lys Asn Trp Thr Ile Thr Arg Leu Asn Gly Asp Tyr Ala
            660                 665                 670         
Gln Leu Ser Leu Arg Ile Leu Tyr Leu Glu Ala Gly Met Tyr Asp Val
        675                 680                 685             
Pro Ile Ile Val Thr Asp Ser Gly Asn Pro Pro Leu Ser Asn Thr Ser
    690                 695                 700                 
Ile Ile Lys Val Lys Val Cys Pro Cys Asp Asp Asn Gly Asp Cys Thr
705                 710                 715                 720 
Thr Ile Gly Ala Val Ala Ala Ala Gly Leu Gly Thr Gly Ala Ile Val
                725                 730                 735     
Ala Ile Leu Ile Cys Ile Leu Ile Leu Leu Thr Met Val Leu Leu Phe
            740                 745                 750         
Val Met Trp Met Lys Arg Arg Glu Lys Glu Arg His Thr Lys Gln Leu
        755                 760                 765             
Leu Ile Asp Pro Glu Asp Asp Val Arg Asp Asn Ile Leu Lys Tyr Asp
    770                 775                 780                 
Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Leu Ser Gln Leu
785                 790                 795                 800 
Gln Gln Pro Glu Ala Met Gly His Val Pro Ser Lys Ala Pro Gly Val
                805                 810                 815     
Arg Arg Val Asp Glu Arg Pro Val Gly Ala Glu Pro Gln Tyr Pro Ile
            820                 825                 830         
Arg Pro Met Val Pro His Pro Gly Asp Ile Gly Asp Phe Ile Asn Glu
        835                 840                 845             
Gly Leu Arg Ala Ala Asp Asn Asp Pro Thr Ala Pro Pro Tyr Asp Ser
    850                 855                 860                 
Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Thr Ala Gly Ser Val
865                 870                 875                 880 
Ser Ser Leu Asn Ser Ser Ser Ser Gly Asp Gln Asp Tyr Asp Tyr Leu
                885                 890                 895     
Asn Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly
            900                 905                 910         
Gly Glu Glu Asp
        915     


<210> 6329
<211> 354
<212> PRT
<213> Homo sapiens

<400> 6329
Met Gly Lys Leu Val Ala Leu Val Leu Leu Gly Val Gly Leu Ser Leu
 1               5                  10                  15      
Val Gly Glu Met Phe Leu Ala Phe Arg Glu Arg Val Asn Ala Ser Arg
            20                  25                  30          
Glu Val Glu Pro Val Glu Pro Glu Asn Cys His Leu Ile Glu Glu Leu
        35                  40                  45              
Glu Ser Gly Ser Glu Asp Ile Asp Ile Leu Pro Ser Gly Leu Ala Phe
    50                  55                  60                  
Ile Ser Ser Gly Leu Lys Tyr Pro Gly Met Pro Asn Phe Ala Pro Asp
65                  70                  75                  80  
Glu Pro Gly Lys Ile Phe Leu Met Asp Leu Asn Glu Gln Asn Pro Arg
                85                  90                  95      
Ala Gln Ala Leu Glu Ile Ser Gly Gly Phe Asp Lys Glu Leu Phe Asn
            100                 105                 110         
Pro His Gly Ile Ser Ile Phe Ile Asp Lys Asp Asn Thr Val Tyr Leu
        115                 120                 125             
Tyr Val Val Asn His Pro His Met Lys Ser Thr Val Glu Ile Phe Lys
    130                 135                 140                 
Phe Glu Glu Gln Gln Arg Ser Leu Val Tyr Leu Lys Thr Ile Lys His
145                 150                 155                 160 
Glu Leu Leu Lys Ser Val Asn Asp Ile Val Val Leu Gly Pro Glu Gln
                165                 170                 175     
Phe Tyr Ala Thr Arg Asp His Tyr Phe Thr Asn Ser Leu Leu Ser Phe
            180                 185                 190         
Phe Glu Met Ile Leu Asp Leu Arg Trp Thr Tyr Val Leu Phe Tyr Ser
        195                 200                 205             
Pro Arg Glu Val Lys Val Val Ala Lys Gly Phe Cys Ser Ala Asn Gly
    210                 215                 220                 
Ile Thr Val Ser Ala Asp Gln Lys Tyr Val Tyr Val Ala Asp Val Ala
225                 230                 235                 240 
Ala Lys Asn Ile His Ile Met Glu Lys His Asp Asn Trp Asp Leu Thr
                245                 250                 255     
Gln Leu Lys Val Ile Gln Leu Gly Thr Leu Val Asp Asn Leu Thr Val
            260                 265                 270         
Asp Pro Ala Thr Gly Asp Ile Leu Ala Gly Cys His Pro Asn Pro Met
        275                 280                 285             
Lys Leu Leu Asn Tyr Asn Pro Glu Asp Pro Pro Gly Ser Glu Val Leu
    290                 295                 300                 
Arg Ile Gln Asn Val Leu Ser Glu Lys Pro Arg Val Ser Thr Val Tyr
305                 310                 315                 320 
Ala Asn Asn Gly Ser Val Leu Gln Gly Thr Ser Val Ala Ser Val Tyr
                325                 330                 335     
His Gly Lys Ile Leu Ile Gly Thr Val Phe His Lys Thr Leu Tyr Cys
            340                 345                 350         
Glu Leu
        


<210> 6330
<211> 354
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 347
<223> Xaa = Any Amino Acid

<400> 6330
Met Gly Lys Leu Val Ala Leu Val Leu Leu Gly Val Gly Leu Ser Leu
 1               5                  10                  15      
Val Gly Glu Met Phe Leu Ala Phe Arg Glu Arg Val Asn Ala Ser Arg
            20                  25                  30          
Glu Val Glu Pro Val Glu Pro Glu Asn Cys His Leu Ile Glu Glu Leu
        35                  40                  45              
Glu Ser Gly Ser Glu Asp Ile Asp Ile Leu Pro Ser Gly Leu Ala Phe
    50                  55                  60                  
Ile Ser Ser Gly Leu Lys Tyr Pro Gly Met Pro Asn Phe Ala Pro Asp
65                  70                  75                  80  
Glu Pro Gly Lys Ile Phe Leu Met Asp Leu Asn Glu Gln Asn Pro Arg
                85                  90                  95      
Ala Gln Ala Leu Glu Ile Ser Gly Gly Phe Asp Lys Glu Leu Phe Asn
            100                 105                 110         
Pro His Gly Ile Ser Ile Phe Ile Asp Lys Asp Asn Thr Val Tyr Leu
        115                 120                 125             
Tyr Val Val Asn His Pro His Met Lys Ser Thr Val Glu Ile Phe Lys
    130                 135                 140                 
Phe Glu Glu Gln Gln Arg Ser Leu Val Tyr Leu Lys Thr Ile Lys His
145                 150                 155                 160 
Glu Leu Leu Lys Ser Val Asn Asp Ile Val Val Leu Gly Pro Glu Gln
                165                 170                 175     
Phe Tyr Ala Thr Arg Asp His Tyr Phe Thr Asn Ser Leu Leu Ser Phe
            180                 185                 190         
Phe Glu Met Ile Leu Asp Leu Arg Trp Thr Tyr Val Leu Phe Tyr Ser
        195                 200                 205             
Pro Arg Glu Val Lys Val Val Ala Lys Gly Phe Cys Ser Ala Asn Gly
    210                 215                 220                 
Ile Thr Val Ser Ala Asp Gln Lys Tyr Val Tyr Val Ala Asp Val Ala
225                 230                 235                 240 
Ala Lys Asn Ile His Ile Met Glu Lys His Asp Asn Trp Asp Leu Thr
                245                 250                 255     
Gln Leu Lys Val Ile Gln Leu Gly Thr Leu Val Asp Asn Leu Thr Val
            260                 265                 270         
Asp Pro Ala Thr Gly Asp Ile Leu Ala Gly Cys His Pro Asn Pro Met
        275                 280                 285             
Lys Leu Leu Asn Tyr Asn Pro Glu Asp Pro Pro Gly Ser Glu Val Leu
    290                 295                 300                 
Arg Ile Gln Asn Val Leu Ser Glu Lys Pro Arg Val Ser Thr Val Tyr
305                 310                 315                 320 
Ala Asn Asn Gly Ser Val Leu Gln Gly Thr Ser Val Ala Ser Val Tyr
                325                 330                 335     
His Gly Lys Ile Leu Ile Gly Thr Val Phe Xaa Lys Thr Leu Tyr Cys
            340                 345                 350         
Glu Leu
        


<210> 6331
<211> 468
<212> PRT
<213> Homo sapiens

<400> 6331
Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro
 1               5                  10                  15      
Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg
            20                  25                  30          
Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro
        35                  40                  45              
Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys
    50                  55                  60                  
Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg
65                  70                  75                  80  
Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys
                85                  90                  95      
Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val
            100                 105                 110         
Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser
        115                 120                 125             
Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr
    130                 135                 140                 
Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp
145                 150                 155                 160 
Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys
                165                 170                 175     
Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met
            180                 185                 190         
Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe
        195                 200                 205             
Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val
    210                 215                 220                 
Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp
225                 230                 235                 240 
Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg
                245                 250                 255     
Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp
            260                 265                 270         
Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His
        275                 280                 285             
Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser
    290                 295                 300                 
Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser
305                 310                 315                 320 
Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr
                325                 330                 335     
Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr
            340                 345                 350         
Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu
        355                 360                 365             
Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile
    370                 375                 380                 
Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly
385                 390                 395                 400 
Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu
                405                 410                 415     
Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val
            420                 425                 430         
Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro
        435                 440                 445             
Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr
    450                 455                 460                 
Phe Phe Pro Arg
465             


<210> 6332
<211> 365
<212> PRT
<213> Homo sapiens

<400> 6332
Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro
 1               5                  10                  15      
Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg
            20                  25                  30          
Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro
        35                  40                  45              
Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys
    50                  55                  60                  
Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg
65                  70                  75                  80  
Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys
                85                  90                  95      
Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val
            100                 105                 110         
Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser
        115                 120                 125             
Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr
    130                 135                 140                 
Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp
145                 150                 155                 160 
Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys
                165                 170                 175     
Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met
            180                 185                 190         
Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe
        195                 200                 205             
Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val
    210                 215                 220                 
Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp
225                 230                 235                 240 
Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg
                245                 250                 255     
Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp
            260                 265                 270         
Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His
        275                 280                 285             
Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser
    290                 295                 300                 
Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser
305                 310                 315                 320 
Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr
                325                 330                 335     
Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr
            340                 345                 350         
Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu
        355                 360                 365 


<210> 6333
<211> 514
<212> PRT
<213> Homo sapiens

<400> 6333
Met Ala Val Trp Leu Ala Gln Trp Leu Gly Pro Leu Leu Leu Val Ser
 1               5                  10                  15      
Leu Trp Gly Leu Leu Ala Pro Ala Ser Leu Leu Arg Arg Leu Gly Glu
            20                  25                  30          
His Ile Gln Gln Phe Gln Glu Ser Ser Ala Gln Gly Leu Gly Leu Ser
        35                  40                  45              
Leu Gly Pro Gly Ala Ala Ala Leu Pro Lys Val Gly Trp Leu Glu Gln
    50                  55                  60                  
Leu Leu Asp Pro Phe Asn Val Ser Asp Arg Arg Ser Phe Leu Gln Arg
65                  70                  75                  80  
Tyr Trp Val Asn Asp Gln His Trp Val Gly Gln Asp Gly Pro Ile Phe
                85                  90                  95      
Leu His Leu Gly Gly Glu Gly Ser Leu Gly Pro Gly Ser Val Met Arg
            100                 105                 110         
Gly His Pro Ala Ala Leu Ala Pro Ala Trp Gly Ala Leu Val Ile Ser
        115                 120                 125             
Leu Glu His Arg Phe Tyr Gly Leu Ser Ile Pro Ala Gly Gly Leu Glu
    130                 135                 140                 
Met Ala Gln Leu Arg Phe Leu Ser Ser Arg Leu Ala Leu Ala Asp Val
145                 150                 155                 160 
Val Ser Ala Arg Leu Ala Leu Ser Arg Leu Phe Asn Ile Ser Ser Ser
                165                 170                 175     
Ser Pro Trp Ile Cys Phe Gly Gly Ser Tyr Ala Gly Ser Leu Ala Ala
            180                 185                 190         
Trp Ala Arg Leu Lys Phe Pro His Leu Ile Phe Ala Ser Val Ala Ser
        195                 200                 205             
Ser Ala Pro Val Arg Ala Val Leu Asp Phe Ser Glu Tyr Asn Asp Val
    210                 215                 220                 
Val Ser Arg Ser Leu Met Ser Thr Ala Ile Gly Gly Ser Leu Glu Cys
225                 230                 235                 240 
Arg Ala Ala Val Ser Val Ala Phe Ala Glu Val Glu Arg Arg Leu Arg
                245                 250                 255     
Ser Gly Gly Ala Ala Gln Ala Ala Leu Arg Thr Glu Leu Ser Ala Cys
            260                 265                 270         
Gly Pro Leu Gly Arg Ala Glu Asn Gln Ala Glu Leu Leu Gly Ala Leu
        275                 280                 285             
Gln Ala Leu Val Gly Gly Val Val Gln Tyr Asp Gly Gln Thr Gly Ala
    290                 295                 300                 
Pro Leu Ser Val Arg Gln Leu Cys Gly Leu Leu Leu Gly Gly Gly Gly
305                 310                 315                 320 
Asn Arg Ser His Ser Thr Pro Tyr Cys Gly Leu Arg Arg Ala Val Gln
                325                 330                 335     
Ile Val Leu His Ser Leu Gly Gln Lys Cys Leu Ser Phe Ser Arg Ala
            340                 345                 350         
Glu Thr Val Ala Gln Leu Arg Ser Thr Glu Pro Gln Leu Ser Gly Val
        355                 360                 365             
Gly Asp Arg Gln Trp Leu Tyr Gln Thr Cys Thr Glu Phe Gly Phe Tyr
    370                 375                 380                 
Val Thr Cys Glu Asn Pro Arg Cys Pro Phe Ser Gln Leu Pro Ala Leu
385                 390                 395                 400 
Pro Ser Gln Leu Asp Leu Cys Glu Gln Val Phe Gly Leu Ser Ala Leu
                405                 410                 415     
Ser Val Ala Gln Ala Val Ala Gln Thr Asn Ser Tyr Tyr Gly Gly Gln
            420                 425                 430         
Thr Pro Gly Ala Asn Lys Val Leu Phe Val Asn Gly Asp Thr Asp Pro
        435                 440                 445             
Trp His Val Leu Ser Val Thr Gln Ala Leu Gly Ser Ser Glu Ser Thr
    450                 455                 460                 
Leu Leu Ile Arg Thr Gly Ser His Cys Leu Asp Met Ala Pro Glu Arg
465                 470                 475                 480 
Pro Ser Asp Ser Pro Ser Leu Arg Leu Gly Arg Gln Asn Ile Phe Gln
                485                 490                 495     
Gln Leu Gln Thr Trp Leu Lys Leu Ala Lys Glu Ser Gln Ile Lys Gly
            500                 505                 510         
Glu Val
        


<210> 6334
<211> 267
<212> PRT
<213> Homo sapiens

<400> 6334
Met Pro Arg Ser Cys Cys Ser Arg Ser Gly Ala Leu Leu Leu Ala Leu
 1               5                  10                  15      
Leu Leu Gln Ala Ser Met Glu Val Arg Gly Trp Cys Leu Glu Ser Ser
            20                  25                  30          
Gln Cys Gln Asp Leu Thr Thr Glu Ser Asn Leu Leu Glu Cys Ile Arg
        35                  40                  45              
Ala Cys Lys Pro Asp Leu Ser Ala Glu Thr Pro Met Phe Pro Gly Asn
    50                  55                  60                  
Gly Asp Glu Gln Pro Leu Thr Glu Asn Pro Arg Lys Tyr Val Met Gly
65                  70                  75                  80  
His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser Ser Ser Ser Gly
                85                  90                  95      
Ser Ser Gly Ala Gly Gln Lys Arg Glu Asp Val Ser Ala Gly Glu Asp
            100                 105                 110         
Cys Gly Pro Leu Pro Glu Gly Gly Pro Glu Pro Arg Ser Asp Gly Ala
        115                 120                 125             
Lys Pro Gly Pro Arg Glu Gly Lys Arg Ser Tyr Ser Met Glu His Phe
    130                 135                 140                 
Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr
145                 150                 155                 160 
Pro Asn Gly Ala Glu Asp Glu Ser Ala Glu Ala Phe Pro Leu Glu Phe
                165                 170                 175     
Lys Arg Glu Leu Thr Gly Gln Arg Leu Arg Glu Gly Asp Gly Pro Asp
            180                 185                 190         
Gly Pro Ala Asp Asp Gly Ala Gly Ala Gln Ala Asp Leu Glu His Ser
        195                 200                 205             
Leu Leu Val Ala Ala Glu Lys Lys Asp Glu Gly Pro Tyr Arg Met Glu
    210                 215                 220                 
His Phe Arg Trp Gly Ser Pro Pro Lys Asp Lys Arg Tyr Gly Gly Phe
225                 230                 235                 240 
Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr Leu Phe Lys Asn
                245                 250                 255     
Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu
            260                 265         


<210> 6335
<211> 224
<212> PRT
<213> Homo sapiens

<400> 6335
Met Arg Val Ser Gly Val Leu Arg Leu Leu Ala Leu Ile Phe Ala Ile
 1               5                  10                  15      
Val Thr Thr Trp Met Phe Ile Arg Ser Tyr Met Ser Phe Ser Met Lys
            20                  25                  30          
Thr Ile Arg Leu Pro Arg Trp Leu Ala Ala Ser Pro Thr Lys Glu Ile
        35                  40                  45              
Gln Val Lys Lys Tyr Lys Cys Gly Leu Ile Lys Pro Cys Pro Ala Asn
    50                  55                  60                  
Tyr Phe Ala Phe Lys Ile Cys Ser Gly Ala Ala Asn Val Val Gly Pro
65                  70                  75                  80  
Thr Met Cys Phe Glu Asp Arg Met Ile Met Ser Pro Val Lys Asn Asn
                85                  90                  95      
Val Gly Arg Gly Leu Asn Ile Ala Leu Val Asn Gly Thr Thr Gly Ala
            100                 105                 110         
Val Leu Gly Gln Lys Ala Phe Asp Met Tyr Ser Gly Asp Val Met His
        115                 120                 125             
Leu Val Lys Phe Leu Lys Glu Ile Pro Gly Gly Ala Leu Val Leu Val
    130                 135                 140                 
Ala Ser Tyr Asp Asp Pro Gly Thr Lys Met Asn Asp Glu Ser Arg Lys
145                 150                 155                 160 
Leu Phe Ser Asp Leu Gly Ser Ser Tyr Ala Lys Gln Leu Gly Phe Arg
                165                 170                 175     
Asp Ser Trp Val Phe Ile Gly Ala Lys Asp Leu Arg Gly Lys Ser Pro
            180                 185                 190         
Phe Glu Gln Phe Leu Lys Asn Ser Pro Asp Thr Asn Lys Tyr Glu Gly
        195                 200                 205             
Trp Pro Glu Leu Leu Glu Met Glu Gly Cys Met Pro Pro Lys Pro Phe
    210                 215                 220                 


<210> 6336
<211> 323
<212> PRT
<213> Homo sapiens

<400> 6336
Ser Ala Phe Gln Asn Gly Gly Gly Gly Gly Ile Trp Cys Ala Trp Pro
 1               5                  10                  15      
Gly Gly Leu Glu Ala Pro Ala Ala Ala Met Pro Ala Arg Gly Arg Cys
            20                  25                  30          
Arg Gln Ala Leu Val Pro Arg Ala Phe His Ala Ser Ala Val Gly Leu
        35                  40                  45              
Arg Ser Ser Asp Glu Gln Lys Gln Gln Pro Pro Asn Ser Phe Ser Gln
    50                  55                  60                  
Gln His Ser Glu Thr Gln Gly Ala Glu Lys Pro Asp Pro Glu Ser Ser
65                  70                  75                  80  
His Ser Pro Pro Arg Tyr Thr Asp Gln Gly Gly Glu Glu Glu Glu Asp
                85                  90                  95      
Tyr Glu Ser Glu Glu Gln Leu Gln His Arg Ile Leu Thr Ala Ala Leu
            100                 105                 110         
Glu Phe Val Pro Ala His Gly Trp Thr Ala Glu Ala Ile Ala Glu Gly
        115                 120                 125             
Ala Gln Ser Leu Gly Leu Ser Ser Gly Ser Ser Gln His Val Ser Gly
    130                 135                 140                 
Arg Met Gly Ser Glu Leu Ile Leu His Phe Val Thr Gln Cys Asn Thr
145                 150                 155                 160 
Arg Leu Thr Arg Val Leu Glu Glu Glu Gln Lys Leu Val Gln Leu Gly
                165                 170                 175     
Gln Ala Glu Lys Arg Lys Thr Asp Gln Phe Leu Arg Asp Ala Val Glu
            180                 185                 190         
Thr Arg Leu Arg Met Leu Ile Pro Tyr Ile Glu His Trp Pro Arg Ala
        195                 200                 205             
Leu Ser Ile Leu Met Leu Pro His Asn Ile Pro Ser Ser Leu Ser Leu
    210                 215                 220                 
Leu Thr Ser Met Val Asp Asp Met Trp His Tyr Ala Gly Asp Gln Ser
225                 230                 235                 240 
Thr Asp Phe Asn Trp Tyr Thr Arg Arg Ala Met Leu Ala Ala Ile Tyr
                245                 250                 255     
Asn Thr Thr Glu Leu Val Met Met Gln Asp Ser Ser Pro Asp Phe Glu
            260                 265                 270         
Asp Thr Trp Arg Phe Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met
        275                 280                 285             
Gly His Thr Ala Lys Gln Val Lys Ser Thr Gly Glu Ala Leu Val Gln
    290                 295                 300                 
Gly Leu Met Gly Ala Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn
305                 310                 315                 320 
Gln Arg Arg
            


<210> 6337
<211> 323
<212> PRT
<213> Homo sapiens

<400> 6337
Val Pro Ala Ser Lys Met Ala Ala Ala Ala Val Ser Gly Ala Leu Gly
 1               5                  10                  15      
Arg Ala Gly Trp Arg Leu Leu Gln Leu Arg Cys Leu Pro Val Ala Arg
            20                  25                  30          
Cys Arg Gln Ala Leu Val Pro Arg Ala Phe His Ala Ser Ala Val Gly
        35                  40                  45              
Leu Arg Ser Ser Asp Glu Gln Lys Gln Gln Pro Pro Asn Ser Phe Ser
    50                  55                  60                  
Gln Gln His Ser Glu Thr Gln Gly Ala Glu Lys Pro Asp Pro Glu Ser
65                  70                  75                  80  
Ser His Ser Pro Pro Arg Tyr Thr Asp Gln Gly Gly Glu Glu Glu Glu
                85                  90                  95      
Asp Tyr Glu Ser Glu Glu Gln Leu Gln His Arg Ile Leu Thr Ala Ala
            100                 105                 110         
Leu Glu Phe Val Pro Ala His Gly Trp Thr Ala Glu Ala Ile Ala Glu
        115                 120                 125             
Gly Ala Gln Ser Leu Gly Leu Ser Ser Ala Ala Ala Ser Met Phe Gly
    130                 135                 140                 
Lys Asp Gly Ser Glu Leu Ile Leu His Phe Val Thr Gln Cys Asn Thr
145                 150                 155                 160 
Arg Leu Thr Arg Val Leu Glu Glu Glu Gln Lys Leu Val Gln Leu Gly
                165                 170                 175     
Gln Ala Glu Lys Arg Lys Thr Asp Gln Phe Leu Arg Asp Ala Val Glu
            180                 185                 190         
Thr Arg Leu Arg Met Leu Ile Pro Tyr Ile Glu His Trp Pro Arg Ala
        195                 200                 205             
Leu Ser Ile Leu Met Leu Pro His Asn Ile Pro Ser Ser Leu Ser Leu
    210                 215                 220                 
Leu Thr Ser Met Val Asp Asp Met Trp His Tyr Ala Gly Asp Gln Ser
225                 230                 235                 240 
Thr Asp Phe Asn Trp Tyr Thr Arg Arg Ala Met Leu Ala Ala Ile Tyr
                245                 250                 255     
Asn Thr Thr Glu Leu Val Met Met Gln Asp Ser Ser Pro Asp Phe Glu
            260                 265                 270         
Asp Thr Trp Arg Phe Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met
        275                 280                 285             
Gly His Thr Ala Lys Gln Val Lys Ser Thr Gly Glu Ala Leu Val Gln
    290                 295                 300                 
Gly Leu Met Gly Ala Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn
305                 310                 315                 320 
Gln Arg Arg
            


<210> 6338
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 6338
Pro Arg Arg Leu Pro Leu Trp Leu Ala Ala Pro Arg Arg Arg Cys Thr
 1               5                  10                  15      
Pro Asp Pro Ala Ala Val Pro Arg Ala Met Asp Leu Pro Arg Gly Leu
            20                  25                  30          
Val Val Ala Trp Ala Leu Ser Leu Trp Pro Gly Phe Thr Asp Thr Phe
        35                  40                  45              
Asn Met Asp Thr Arg Lys Pro Arg Val Ile Pro Gly Ser Arg Thr Ala
    50                  55                  60                  
Phe Phe Gly Tyr Thr Val Gln Gln His Asp Ile Ser Gly Asn Lys Trp
65                  70                  75                  80  
Leu Val Val Gly Ala Pro Leu Glu Thr Asn Gly Tyr Gln Lys Thr Gly
                85                  90                  95      
Asp Val Tyr Lys Cys Pro Val Ile His Gly Asn Cys Thr Lys Leu Asn
            100                 105                 110         
Leu Gly Arg Val Thr Leu Ser Asn Val Ser Glu Arg Lys Asp Asn Met
        115                 120                 125             
Arg Leu Gly Leu Ser Leu Ala Thr Asn Pro Lys Asp Asn Ser Phe Leu
    130                 135                 140                 
Ala Cys Ser Pro Leu Trp Ser His Glu Cys Gly Ser Ser Tyr Tyr Thr
145                 150                 155                 160 
Thr Gly Met Cys Ser Arg Val Asn Ser Asn Phe Arg Phe Ser Lys Thr
                165                 170                 175     
Val Ala Pro Ala Leu Gln Arg Cys Gln Thr Tyr Met Asp Ile Val Ile
            180                 185                 190         
Val Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Val Glu Val Gln His
        195                 200                 205             
Phe Leu Ile Asn Ile Leu Lys Lys Phe Tyr Ile Gly Pro Gly Gln Ile
    210                 215                 220                 
Gln Val Gly Val Val Gln Tyr Gly Glu Asp Val Val His Glu Phe His
225                 230                 235                 240 
Leu Asn Asp Tyr Arg Ser Val Lys Asp Val Val Glu Ala Ala Ser His
                245                 250                 255     
Ile Glu Gln Arg Gly Gly Thr Glu Thr Arg Thr Ala Phe Gly Ile Glu
            260                 265                 270         
Phe Ala Arg Ser Glu Ala Phe Gln Lys Gly Gly Arg Lys Gly Ala Lys
        275                 280                 285             
Lys Val Met Ile Val Ile Thr Asp Gly Glu Ser His Asp Ser Pro Asp
    290                 295                 300                 
Leu Glu Lys Val Ile Gln Gln Ser Glu Arg Asp Asn Val Thr Arg Tyr
305                 310                 315                 320 
Ala Val Ala Val Leu Gly Tyr Tyr Asn Arg Arg Gly Ile Asn Pro Glu
                325                 330                 335     
Thr Phe Leu Asn Glu Ile Lys Tyr Ile Ala Ser Asp Pro Asp Asp Lys
            340                 345                 350         
His Phe Phe Asn Val Thr Asp Glu Ala Ala Leu Lys Asp Ile Val Asp
        355                 360                 365             
Ala Leu Gly Asp Arg Ile Phe Ser Leu Glu Gly Thr Asn Lys Asn Glu
    370                 375                 380                 
Thr Ser Phe Gly Leu Glu Met Ser Gln Thr Gly Phe Ser Ser His Val
385                 390                 395                 400 
Val Glu Asp Gly Val Leu Leu Gly Ala Val Gly Ala Tyr Asp Trp Asn
                405                 410                 415     
Gly Ala Val Leu Lys Glu Thr Ser Ala Gly Lys Val Ile Pro Leu Arg
            420                 425                 430         
Glu Ser Tyr Leu Lys Glu Phe Pro Glu Glu Leu Lys Asn His Gly Ala
        435                 440                 445             
Tyr Leu Gly Tyr Thr Val Thr Ser Val Val Ser Ser Arg Gln Gly Arg
    450                 455                 460                 
Val Tyr Val Ala Gly Ala Pro Arg Phe Asn His Thr Gly Lys Val Ile
465                 470                 475                 480 
Leu Phe Thr Met His Asn Asn Arg Ser Leu Thr Ile His Gln Ala Met
                485                 490                 495     
Arg Gly Gln Gln Ile Gly Ser Tyr Phe Gly Ser Glu Ile Thr Ser Val
            500                 505                 510         
Asp Ile Asp Gly Asp Gly Val Thr Asp Val Leu Leu Val Gly Ala Pro
        515                 520                 525             
Met Tyr Phe Asn Glu Gly Arg Glu Arg Gly Lys Val Tyr Val Tyr Glu
    530                 535                 540                 
Leu Arg Gln Asn Leu Phe Val Tyr Asn Gly Thr Leu Lys Asp Ser His
545                 550                 555                 560 
Ser Tyr Gln Asn Ala Arg Phe Gly Ser Ser Ile Ala Ser Val Arg Asp
                565                 570                 575     
Leu Asn Gln Asp Ser Tyr Asn Asp Val Val Val Gly Ala Pro Leu Glu
            580                 585                 590         
Asp Asn His Ala Gly Ala Ile Tyr Ile Phe His Gly Phe Arg Gly Ser
        595                 600                 605             
Ile Leu Lys Thr Pro Lys Gln Arg Ile Thr Ala Ser Glu Leu Ala Thr
    610                 615                 620                 
Gly Leu Gln Tyr Phe Gly Cys Ser Ile His Gly Gln Leu Asp Leu Asn
625                 630                 635                 640 
Glu Asp Gly Leu Ile Asp Leu Ala Val Gly Ala Leu Gly Asn Ala Val
                645                 650                 655     
Ile Leu Trp Ser Arg Pro Val Val Gln Ile Asn Ala Ser Leu His Phe
            660                 665                 670         
Glu Pro Ser Lys Ile Asn Ile Phe His Arg Asp Cys Lys Arg Ser Gly
        675                 680                 685             
Arg Asp Ala Thr Cys Leu Ala Ala Phe Leu Cys Phe Thr Pro Ile Phe
    690                 695                 700                 
Leu Ala Pro His Phe Gln Thr Thr Thr Val Gly Ile Arg Tyr Asn Ala
705                 710                 715                 720 
Thr Met Asp Glu Arg Arg Tyr Thr Pro Arg Ala His Leu Asp Glu Gly
                725                 730                 735     
Gly Asp Arg Phe Thr Asn Arg Ala Val Leu Leu Ser Ser Gly Gln Glu
            740                 745                 750         
Leu Cys Glu Arg Ile Asn Phe His Val Leu Asp Thr Ala Asp Tyr Val
        755                 760                 765             
Lys Pro Val Thr Phe Ser Val Glu Tyr Ser Leu Glu Asp Pro Asp His
    770                 775                 780                 
Gly Pro Met Leu Asp Asp Gly Trp Pro Thr Thr Leu Arg Val Ser Val
785                 790                 795                 800 
Pro Phe Trp Asn Gly Cys Asn Glu Asp Glu His Cys Val Pro Asp Leu
                805                 810                 815     
Val Leu Asp Ala Arg Ser Asp Leu Pro Thr Ala Met Glu Tyr Cys Gln
            820                 825                 830         
Arg Val Leu Arg Lys Pro Ala Gln Asp Cys Ser Ala Tyr Thr Leu Ser
        835                 840                 845             
Phe Asp Thr Thr Val Phe Ile Ile Glu Ser Thr Arg Gln Arg Val Ala
    850                 855                 860                 
Val Glu Ala Thr Leu Glu Asn Arg Gly Glu Asn Ala Tyr Ser Thr Val
865                 870                 875                 880 
Leu Asn Ile Ser Gln Ser Ala Asn Leu Gln Phe Ala Ser Leu Ile Gln
                885                 890                 895     
Lys Glu Asp Ser Asp Gly Ser Ile Glu Cys Val Asn Glu Glu Arg Arg
            900                 905                 910         
Leu Gln Lys Gln Val Cys Asn Val Ser Tyr Pro Phe Phe Arg Ala Lys
        915                 920                 925             
Ala Lys Val Ala Phe Arg Leu Asp Phe Glu Phe Ser Lys Ser Ile Phe
    930                 935                 940                 
Leu His His Leu Glu Ile Glu Leu Ala Ala Gly Ser Asp Ser Asn Glu
945                 950                 955                 960 
Arg Asp Ser Thr Lys Glu Asp Asn Val Ala Pro Leu Arg Phe His Leu
                965                 970                 975     
Lys Tyr Glu Ala Asp Val Leu Phe Thr Arg Ser Ser Ser Leu Ser His
            980                 985                 990         
Tyr Glu Val Lys Pro Asn Ser Ser Leu Glu Arg Tyr Asp Gly Ile Gly
        995                 1000                1005            
Pro Pro Phe Ser Cys Ile Phe Arg Ile Gln Asn Leu Gly Leu Phe Pro
    1010                1015                1020                
Ile His Gly Met Met Met Lys Ile Thr Ile Pro Ile Ala Thr Arg Ser
1025                1030                1035                1040
Gly Asn Arg Leu Leu Lys Leu Arg Asp Phe Leu Thr Asp Glu Val Ala
                1045                1050                1055    
Asn Thr Ser Cys Asn Ile Trp Gly Asn Ser Thr Glu Tyr Arg Pro Thr
            1060                1065                1070        
Pro Val Glu Glu Asp Leu Arg Arg Ala Pro Gln Leu Asn His Ser Asn
        1075                1080                1085            
Ser Asp Val Val Ser Ile Asn Cys Asn Ile Arg Leu Val Pro Asn Gln
    1090                1095                1100                
Glu Ile Asn Phe His Leu Leu Gly Asn Leu Trp Leu Arg Ser Leu Lys
1105                1110                1115                1120
Ala Leu Lys Tyr Lys Ser Met Lys Ile Met Val Asn Ala Ala Leu Gln
                1125                1130                1135    
Arg Gln Phe His Ser Pro Phe Ile Phe Arg Glu Glu Asp Pro Ser Arg
            1140                1145                1150        
Gln Ile Val Phe Glu Ile Ser Lys Gln Glu Asp Trp Gln Val Pro Ile
        1155                1160                1165            
Trp Ile Ile Val Gly Ser Thr Leu Gly Gly Leu Leu Leu Leu Ala Leu
    1170                1175                1180                
Leu Val Leu Ala Leu Trp Lys Leu Gly Phe Phe Arg Ser Ala Arg Arg
1185                1190                1195                1200
Arg Arg Glu Pro Gly Leu Asp Pro Thr Pro Lys Val Leu Glu
                1205                1210                


<210> 6339
<211> 1179
<212> PRT
<213> Homo sapiens

<400> 6339
Met Trp Leu Phe His Thr Leu Leu Cys Ile Ala Ser Leu Ala Leu Leu
 1               5                  10                  15      
Ala Ala Phe Asn Val Asp Val Ala Arg Pro Trp Leu Thr Pro Lys Gly
            20                  25                  30          
Gly Ala Pro Phe Val Leu Ser Ser Leu Leu His Gln Asp Pro Ser Thr
        35                  40                  45              
Asn Gln Thr Trp Leu Leu Val Thr Ser Pro Arg Thr Lys Arg Thr Pro
    50                  55                  60                  
Gly Pro Leu His Arg Cys Ser Leu Val Gln Asp Glu Ile Leu Cys His
65                  70                  75                  80  
Pro Val Glu His Val Pro Ile Pro Lys Gly Arg His Arg Gly Val Thr
                85                  90                  95      
Val Val Arg Ser His His Gly Val Leu Ile Cys Ile Gln Val Leu Val
            100                 105                 110         
Arg Arg Pro His Ser Leu Ser Ser Glu Leu Thr Gly Thr Cys Ser Leu
        115                 120                 125             
Leu Gly Pro Asp Leu Arg Pro Gln Ala Gln Ala Asn Phe Phe Asp Leu
    130                 135                 140                 
Glu Asn Leu Leu Asp Pro Asp Ala Arg Val Asp Thr Gly Asp Cys Tyr
145                 150                 155                 160 
Ser Asn Lys Glu Gly Gly Gly Glu Asp Asp Val Asn Thr Ala Arg Gln
                165                 170                 175     
Arg Arg Ala Leu Glu Lys Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu
            180                 185                 190         
Asp Glu Glu Glu Glu Glu Ala Gly Thr Glu Ile Ala Ile Ile Leu Asp
        195                 200                 205             
Gly Ser Gly Ser Ile Asp Pro Pro Asp Phe Gln Arg Ala Lys Asp Phe
    210                 215                 220                 
Ile Ser Asn Met Met Arg Asn Phe Tyr Glu Lys Cys Phe Glu Cys Asn
225                 230                 235                 240 
Phe Ala Leu Val Gln Tyr Gly Gly Val Ile Gln Thr Glu Phe Asp Leu
                245                 250                 255     
Arg Asp Ser Gln Asp Val Met Ala Ser Leu Ala Arg Val Gln Asn Ile
            260                 265                 270         
Thr Gln Val Gly Ser Val Thr Lys Thr Ala Ser Ala Met Gln His Val
        275                 280                 285             
Leu Asp Ser Ile Phe Thr Ser Ser His Gly Ser Arg Arg Lys Ala Ser
    290                 295                 300                 
Lys Val Met Val Val Leu Thr Asp Gly Gly Ile Phe Glu Asp Pro Leu
305                 310                 315                 320 
Asn Leu Thr Thr Val Ile Asn Ser Pro Lys Met Gln Gly Val Glu Arg
                325                 330                 335     
Phe Ala Ile Gly Val Gly Glu Glu Phe Lys Ser Ala Arg Thr Ala Arg
            340                 345                 350         
Glu Leu Asn Leu Ile Ala Ser Asp Pro Asp Glu Thr His Ala Phe Lys
        355                 360                 365             
Val Thr Asn Tyr Met Ala Leu Asp Gly Leu Leu Ser Lys Leu Arg Tyr
    370                 375                 380                 
Asn Ile Ile Ser Met Glu Gly Thr Val Gly Asp Ala Leu His Tyr Gln
385                 390                 395                 400 
Leu Ala Gln Ile Gly Phe Ser Ala Gln Ile Leu Asp Glu Arg Gln Val
                405                 410                 415     
Leu Leu Gly Ala Val Gly Ala Phe Asp Trp Ser Gly Gly Ala Leu Leu
            420                 425                 430         
Tyr Asp Thr Arg Ser Arg Arg Gly Arg Phe Leu Asn Gln Thr Ala Ala
        435                 440                 445             
Ala Ala Ala Asp Ala Glu Ala Ala Gln Tyr Ser Tyr Leu Gly Tyr Ala
    450                 455                 460                 
Val Ala Val Leu His Lys Thr Cys Ser Leu Ser Tyr Val Ala Gly Ala
465                 470                 475                 480 
Pro Gln Tyr Lys His His Gly Ala Val Phe Glu Leu Gln Lys Glu Gly
                485                 490                 495     
Arg Glu Ala Ser Phe Leu Pro Val Leu Glu Gly Glu Gln Met Gly Ser
            500                 505                 510         
Tyr Phe Gly Ser Glu Leu Cys Pro Val Asp Ile Asp Met Asp Gly Ser
        515                 520                 525             
Thr Asp Phe Leu Leu Val Ala Ala Pro Phe Tyr His Val His Gly Glu
    530                 535                 540                 
Glu Gly Arg Val Tyr Val Tyr Arg Leu Ser Glu Gln Asp Gly Ser Phe
545                 550                 555                 560 
Ser Leu Ala Arg Ile Leu Ser Gly His Pro Gly Phe Thr Asn Ala Arg
                565                 570                 575     
Phe Gly Phe Ala Met Ala Ala Met Gly Asp Leu Ser Gln Asp Lys Leu
            580                 585                 590         
Thr Asp Val Ala Ile Gly Ala Pro Leu Glu Gly Phe Gly Ala Asp Asp
        595                 600                 605             
Gly Ala Ser Phe Gly Ser Val Tyr Ile Tyr Asn Gly His Trp Asp Gly
    610                 615                 620                 
Leu Ser Ala Ser Pro Ser Gln Arg Ile Arg Ala Ser Thr Val Ala Pro
625                 630                 635                 640 
Gly Leu Gln Tyr Phe Gly Met Ser Met Ala Gly Gly Phe Asp Ile Ser
                645                 650                 655     
Gly Asp Gly Leu Ala Asp Ile Thr Val Gly Thr Leu Gly Gln Ala Val
            660                 665                 670         
Val Phe Arg Ser Arg Pro Val Val Arg Leu Lys Val Ser Met Ala Phe
        675                 680                 685             
Thr Pro Ser Ala Leu Pro Ile Gly Phe Asn Gly Val Val Asn Val Arg
    690                 695                 700                 
Leu Cys Phe Glu Ile Ser Ser Val Thr Thr Ala Ser Glu Ser Gly Leu
705                 710                 715                 720 
Arg Glu Ala Leu Leu Asn Phe Thr Leu Asp Val Asp Val Gly Lys Gln
                725                 730                 735     
Arg Arg Arg Leu Gln Cys Ser Asp Val Arg Ser Cys Leu Gly Cys Leu
            740                 745                 750         
Arg Glu Trp Ser Ser Gly Ser Gln Leu Cys Glu Asp Leu Leu Leu Met
        755                 760                 765             
Pro Thr Glu Gly Glu Leu Cys Glu Glu Asp Cys Phe Ser Asn Ala Ser
    770                 775                 780                 
Val Lys Val Ser Tyr Gln Leu Gln Thr Pro Glu Gly Gln Thr Asp His
785                 790                 795                 800 
Pro Gln Pro Ile Leu Asp Arg Tyr Thr Glu Pro Phe Ala Ile Phe Gln
                805                 810                 815     
Leu Pro Tyr Glu Lys Ala Cys Lys Asn Lys Leu Phe Cys Val Ala Glu
            820                 825                 830         
Leu Gln Leu Ala Thr Thr Val Ser Gln Gln Glu Leu Val Val Gly Leu
        835                 840                 845             
Thr Lys Glu Leu Thr Leu Asn Ile Asn Leu Thr Asn Ser Gly Glu Asp
    850                 855                 860                 
Ser Tyr Met Thr Ser Met Ala Leu Asn Tyr Pro Arg Asn Leu Gln Leu
865                 870                 875                 880 
Lys Arg Met Gln Lys Pro Pro Ser Pro Asn Ile Gln Cys Asp Asp Pro
                885                 890                 895     
Gln Pro Val Ala Ser Val Leu Ile Met Asn Cys Arg Ile Gly His Pro
            900                 905                 910         
Val Leu Lys Arg Ser Ser Ala His Val Ser Val Val Trp Gln Leu Glu
        915                 920                 925             
Glu Asn Ala Phe Pro Asn Arg Thr Ala Asp Ile Thr Val Thr Val Thr
    930                 935                 940                 
Asn Ser Asn Glu Arg Arg Ser Leu Ala Asn Glu Thr His Thr Leu Gln
945                 950                 955                 960 
Phe Arg His Gly Phe Val Ala Val Leu Ser Lys Pro Ser Ile Met Tyr
                965                 970                 975     
Val Asn Thr Gly Gln Gly Leu Ser His His Lys Glu Phe Leu Phe His
            980                 985                 990         
Val His Gly Glu Asn Leu Phe Gly Ala Glu Tyr Gln Leu Gln Ile Cys
        995                 1000                1005            
Val Pro Thr Lys Leu Arg Gly Leu Gln Val Ala Ala Val Lys Lys Leu
    1010                1015                1020                
Thr Arg Thr Gln Ala Ser Thr Val Cys Thr Trp Ser Gln Glu Arg Ala
1025                1030                1035                1040
Cys Ala Tyr Ser Ser Val Gln His Val Glu Glu Trp His Ser Val Ser
                1045                1050                1055    
Cys Val Ile Ala Ser Asp Lys Glu Asn Val Thr Val Ala Ala Glu Ile
            1060                1065                1070        
Ser Trp Asp His Ser Glu Glu Leu Leu Lys Asp Val Thr Glu Leu Gln
        1075                1080                1085            
Ile Leu Gly Glu Ile Ser Phe Asn Lys Ser Leu Tyr Glu Gly Leu Asn
    1090                1095                1100                
Ala Glu Asn His Arg Thr Lys Ile Thr Val Val Phe Leu Lys Asp Glu
1105                1110                1115                1120
Lys Tyr His Ser Leu Pro Ile Ile Ile Lys Gly Ser Val Gly Gly Leu
                1125                1130                1135    
Leu Val Leu Ile Val Ile Leu Val Ile Leu Phe Lys Cys Gly Phe Phe
            1140                1145                1150        
Lys Arg Lys Tyr Gln Gln Leu Asn Leu Glu Ser Ile Arg Lys Ala Gln
        1155                1160                1165            
Leu Lys Ser Glu Asn Leu Leu Glu Glu Glu Asn
    1170                1175                


<210> 6340
<211> 1218
<212> PRT
<213> Homo sapiens

<400> 6340
Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu
 1               5                  10                  15      
Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser
            20                  25                  30          
Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu
        35                  40                  45              
Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg
    50                  55                  60                  
Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys
65                  70                  75                  80  
Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser
                85                  90                  95      
Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser
            100                 105                 110         
Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp
        115                 120                 125             
Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp
    130                 135                 140                 
Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met
145                 150                 155                 160 
Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val
                165                 170                 175     
Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr
            180                 185                 190         
Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly
        195                 200                 205             
His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp
    210                 215                 220                 
Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro
225                 230                 235                 240 
Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly
                245                 250                 255     
Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val
            260                 265                 270         
His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp
        275                 280                 285             
Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln
    290                 295                 300                 
Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr
305                 310                 315                 320 
Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala
                325                 330                 335     
Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys
            340                 345                 350         
Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly
        355                 360                 365             
Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser
    370                 375                 380                 
His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys
385                 390                 395                 400 
Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys
                405                 410                 415     
Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala
            420                 425                 430         
Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp
        435                 440                 445             
Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys
    450                 455                 460                 
Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala
465                 470                 475                 480 
Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys
                485                 490                 495     
Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu
            500                 505                 510         
Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr
        515                 520                 525             
Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala
    530                 535                 540                 
Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys
545                 550                 555                 560 
Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp
                565                 570                 575     
Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg
            580                 585                 590         
Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln
        595                 600                 605             
Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr
    610                 615                 620                 
Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn
625                 630                 635                 640 
Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser
                645                 650                 655     
Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser
            660                 665                 670         
Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp
        675                 680                 685             
Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser
    690                 695                 700                 
Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys
705                 710                 715                 720 
Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu
                725                 730                 735     
Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro
            740                 745                 750         
Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys
        755                 760                 765             
Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn
    770                 775                 780                 
Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly
785                 790                 795                 800 
Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp
                805                 810                 815     
Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly
            820                 825                 830         
Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro
        835                 840                 845             
Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile
    850                 855                 860                 
Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys
865                 870                 875                 880 
Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp
                885                 890                 895     
Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro
            900                 905                 910         
Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His
        915                 920                 925             
Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val
    930                 935                 940                 
Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn
945                 950                 955                 960 
Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr
                965                 970                 975     
Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val
            980                 985                 990         
Ser Ala Glu Tyr Ser Ile Tyr Ile Ala Cys Glu Pro Ser Pro Ser Ala
        995                 1000                1005            
Asn Asn Glu Ile His Val Ala Ile Ser Ala Glu Asp Ile Arg Asp Asp
    1010                1015                1020                
Gly Asn Pro Ile Lys Glu Ile Thr Asp Lys Ile Ile Asp Leu Val Ser
1025                1030                1035                1040
Lys Arg Asp Gly Asn Ser Ser Leu Ile Ala Ala Val Ala Glu Val Arg
                1045                1050                1055    
Val Gln Arg Arg Pro Leu Lys Asn Arg Thr Asp Phe Leu Val Pro Leu
            1060                1065                1070        
Leu Ser Ser Val Leu Thr Val Ala Trp Ile Cys Cys Leu Val Thr Ala
        1075                1080                1085            
Phe Tyr Trp Cys Leu Arg Lys Arg Arg Lys Pro Gly Ser His Thr His
    1090                1095                1100                
Ser Ala Ser Glu Asp Asn Thr Thr Asn Asn Val Arg Glu Gln Leu Asn
1105                1110                1115                1120
Gln Ile Lys Asn Pro Ile Glu Lys His Gly Ala Asn Thr Val Pro Ile
                1125                1130                1135    
Lys Asp Tyr Glu Asn Lys Asn Ser Lys Met Ser Lys Ile Arg Thr His
            1140                1145                1150        
Asn Ser Glu Val Glu Glu Asp Asp Met Asp Lys His Gln Gln Lys Ala
        1155                1160                1165            
Arg Phe Ala Lys Gln Pro Ala Tyr Thr Leu Val Asp Arg Glu Glu Lys
    1170                1175                1180                
Pro Pro Asn Gly Thr Pro Thr Lys His Pro Asn Trp Thr Asn Lys Gln
1185                1190                1195                1200
Asp Asn Arg Asp Leu Glu Ser Ala Gln Ser Leu Asn Arg Met Glu Tyr
                1205                1210                1215    
Ile Val
        


<210> 6341
<211> 2559
<212> PRT
<213> Homo sapiens

<400> 6341
Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala
 1               5                  10                  15      
Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu
            20                  25                  30          
Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys
        35                  40                  45              
Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu
    50                  55                  60                  
Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg
65                  70                  75                  80  
Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro
                85                  90                  95      
Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg
            100                 105                 110         
Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg
        115                 120                 125             
Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys
    130                 135                 140                 
Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala
145                 150                 155                 160 
Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg
                165                 170                 175     
Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly
            180                 185                 190         
Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala
        195                 200                 205             
Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro
    210                 215                 220                 
Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr
225                 230                 235                 240 
His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu
                245                 250                 255     
Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys
            260                 265                 270         
Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr
        275                 280                 285             
Gly Ala Tyr Thr Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln
    290                 295                 300                 
Leu Met Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His
305                 310                 315                 320 
Gly Gly Tyr Asn Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys
                325                 330                 335     
Ser Glu Asn Ile Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala
            340                 345                 350         
Thr Cys His Asp Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly
        355                 360                 365             
Arg Thr Gly Leu Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro
    370                 375                 380                 
Cys Asn Glu Gly Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala
385                 390                 395                 400 
Ile Cys Thr Cys Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp
                405                 410                 415     
Val Asp Glu Cys Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys
            420                 425                 430         
Cys Ile Asn Thr Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr
        435                 440                 445             
Thr Gly Pro Arg Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro
    450                 455                 460                 
Cys Gln Asn Asp Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys
465                 470                 475                 480 
Ile Cys Met Pro Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp
                485                 490                 495     
Glu Cys Ala Ser Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys
            500                 505                 510         
Ile Asn Glu Phe Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu
        515                 520                 525             
Cys Gln Tyr Asp Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly
    530                 535                 540                 
Ala Lys Cys Leu Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu
545                 550                 555                 560 
Gly Tyr Thr Gly Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro
                565                 570                 575     
Asp Pro Cys His Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr
            580                 585                 590         
Cys Leu Cys Arg Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile
        595                 600                 605             
Asn Glu Cys Ser Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp
    610                 615                 620                 
Arg Asp Asn Ala Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro
625                 630                 635                 640 
Asn Cys Glu Ile Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser
                645                 650                 655     
Gly Thr Cys Leu Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro
            660                 665                 670         
Gly Tyr Thr Gly Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly
        675                 680                 685             
Asn Pro Cys His Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe
    690                 695                 700                 
Thr Cys Arg Cys Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu
705                 710                 715                 720 
Val Asn Glu Cys Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp
                725                 730                 735     
Ser Leu Asn Gly Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr
            740                 745                 750         
Asn Cys Asp Ile Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn
        755                 760                 765             
Gly Gly Thr Cys Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg
    770                 775                 780                 
Glu Gly Phe Ser Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala
785                 790                 795                 800 
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly
                805                 810                 815     
Tyr Lys Cys Asn Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val
            820                 825                 830         
Val Leu Ala Pro Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys
        835                 840                 845             
Arg Gln Ser Glu Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly
    850                 855                 860                 
Trp Gln Gly Gln Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser
865                 870                 875                 880 
Pro Cys Arg His Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg
                885                 890                 895     
Cys His Cys Gln Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile
            900                 905                 910         
Asp Asp Cys Arg Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp
        915                 920                 925             
Gly Ile Asn Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr
    930                 935                 940                 
Phe Cys Glu Glu Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn
945                 950                 955                 960 
Gly Ala Asn Cys Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro
                965                 970                 975     
Ala Gly Phe Ser Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr
            980                 985                 990         
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser
        995                 1000                1005            
Phe Thr Cys Leu Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln His
    1010                1015                1020                
Asp Val Asn Glu Cys Asp Ser Gln Pro Cys Leu His Gly Gly Thr Cys
1025                1030                1035                1040
Gln Asp Gly Cys Gly Ser Tyr Arg Cys Thr Cys Pro Gln Gly Tyr Thr
                1045                1050                1055    
Gly Pro Asn Cys Gln Asn Leu Val His Trp Cys Asp Ser Ser Pro Cys
            1060                1065                1070        
Lys Asn Gly Gly Lys Cys Trp Gln Thr His Thr Gln Tyr Arg Cys Glu
        1075                1080                1085            
Cys Pro Ser Gly Trp Thr Gly Leu Tyr Cys Asp Val Pro Ser Val Ser
    1090                1095                1100                
Cys Glu Val Ala Ala Gln Arg Gln Gly Val Asp Val Ala Arg Leu Cys
1105                1110                1115                1120
Gln His Gly Gly Leu Cys Val Asp Ala Gly Asn Thr His His Cys Arg
                1125                1130                1135    
Cys Gln Ala Gly Tyr Thr Gly Ser Tyr Cys Glu Asp Leu Val Asp Glu
            1140                1145                1150        
Cys Ser Pro Ser Pro Cys Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu
        1155                1160                1165            
Gly Gly Tyr Ser Cys Lys Cys Val Ala Gly Tyr His Gly Val Asn Cys
    1170                1175                1180                
Ser Glu Glu Ile Asp Glu Cys Leu Ser His Pro Cys Gln Asn Gly Gly
1185                1190                1195                1200
Thr Cys Leu Asp Leu Pro Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly
                1205                1210                1215    
Thr Gln Gly Val His Cys Glu Ile Asn Val Asp Asp Cys Asn Pro Pro
            1220                1225                1230        
Val Asp Pro Val Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys
        1235                1240                1245            
Val Asp Gln Val Gly Gly Tyr Ser Cys Thr Cys Pro Pro Gly Phe Val
    1250                1255                1260                
Gly Glu Arg Cys Glu Gly Asp Val Asn Glu Cys Leu Ser Asn Pro Cys
1265                1270                1275                1280
Asp Ala Arg Gly Thr Gln Asn Cys Val Gln Arg Val Asn Asp Phe His
                1285                1290                1295    
Cys Glu Cys Arg Ala Gly His Thr Gly Arg Arg Cys Glu Ser Val Ile
            1300                1305                1310        
Asn Gly Cys Lys Gly Lys Pro Cys Lys Asn Gly Gly Thr Cys Ala Val
        1315                1320                1325            
Ala Ser Asn Thr Ala Arg Gly Phe Ile Cys Lys Cys Pro Ala Gly Phe
    1330                1335                1340                
Glu Gly Ala Thr Cys Glu Asn Asp Ala Arg Thr Cys Gly Ser Leu Arg
1345                1350                1355                1360
Cys Leu Asn Gly Gly Thr Cys Ile Ser Gly Pro Arg Ser Pro Thr Cys
                1365                1370                1375    
Leu Cys Leu Gly Pro Phe Thr Gly Pro Glu Cys Gln Phe Pro Ala Ser
            1380                1385                1390        
Ser Pro Cys Leu Gly Gly Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu
        1395                1400                1405            
Pro Thr Ser Glu Ser Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe
    1410                1415                1420                
Asn Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala
1425                1430                1435                1440
Gly Arg Asp Ile Pro Pro Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro
                1445                1450                1455    
Glu Cys Gln Glu Asp Ala Gly Asn Lys Val Cys Ser Leu Gln Cys Asn
            1460                1465                1470        
Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn
        1475                1480                1485            
Asp Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe
    1490                1495                1500                
Ser Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe
1505                1510                1515                1520
Asp Gly Phe Asp Cys Gln Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr
                1525                1530                1535    
Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly
            1540                1545                1550        
Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His
        1555                1560                1565            
Val Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Val Val Val Leu Met
    1570                1575                1580                
Pro Pro Glu Gln Leu Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu
1585                1590                1595                1600
Ser Arg Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly
                1605                1610                1615    
Gln Gln Met Ile Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys
            1620                1625                1630        
His Pro Ile Lys Arg Ala Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu
        1635                1640                1645            
Leu Gly Gln Val Lys Ala Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly
    1650                1655                1660                
Arg Arg Arg Arg Glu Leu Asp Pro Met Asp Val Arg Gly Ser Ile Val
1665                1670                1675                1680
Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ala Ser Ser Gln Cys
                1685                1690                1695    
Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser
            1700                1705                1710        
Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu
        1715                1720                1725            
Thr Val Glu Pro Pro Pro Pro Ala Gln Leu His Phe Met Tyr Val Ala
    1730                1735                1740                
Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu
1745                1750                1755                1760
Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe Pro Glu Gly
                1765                1770                1775    
Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg Glu Pro Leu Gly
            1780                1785                1790        
Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn Ala Ser Asp Gly Ala
        1795                1800                1805            
Leu Met Asp Asp Asn Gln Asn Glu Trp Gly Asp Glu Asp Leu Glu Thr
    1810                1815                1820                
Lys Lys Phe Arg Phe Glu Glu Pro Val Val Leu Pro Asp Leu Asp Asp
1825                1830                1835                1840
Gln Thr Asp His Arg Gln Trp Thr Gln Gln His Leu Asp Ala Ala Asp
                1845                1850                1855    
Leu Arg Met Ser Ala Met Ala Pro Thr Pro Pro Gln Gly Glu Val Asp
            1860                1865                1870        
Ala Asp Cys Met Asp Val Asn Val Arg Gly Pro Asp Gly Phe Thr Pro
        1875                1880                1885            
Leu Met Ile Ala Ser Cys Ser Gly Gly Gly Leu Glu Thr Gly Asn Ser
    1890                1895                1900                
Glu Glu Glu Glu Asp Ala Pro Ala Val Ile Ser Asp Phe Ile Tyr Gln
1905                1910                1915                1920
Gly Ala Ser Leu His Asn Gln Thr Asp Arg Thr Gly Glu Thr Ala Leu
                1925                1930                1935    
His Leu Ala Ala Arg Tyr Ser Arg Ser Asp Ala Ala Lys Arg Leu Leu
            1940                1945                1950        
Glu Ala Ser Ala Asp Ala Asn Ile Gln Asp Asn Met Gly Arg Thr Pro
        1955                1960                1965            
Leu His Ala Ala Val Ser Ala Asp Ala Gln Gly Val Phe Gln Ile Leu
    1970                1975                1980                
Ile Arg Asn Arg Ala Thr Asp Leu Asp Ala Arg Met His Asp Gly Thr
1985                1990                1995                2000
Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly Met Leu Glu
                2005                2010                2015    
Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val Asp Asp Leu Gly
            2020                2025                2030        
Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val Asp Ala Ala
        2035                2040                2045            
Val Val Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln Asn Asn Arg
    2050                2055                2060                
Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser Tyr Glu Thr
2065                2070                2075                2080
Ala Lys Val Leu Leu Asp His Phe Ala Asn Arg Asp Ile Thr Asp His
                2085                2090                2095    
Met Asp Arg Leu Pro Arg Asp Ile Ala Gln Glu Arg Met His His Asp
            2100                2105                2110        
Ile Val Arg Leu Leu Asp Glu Tyr Asn Leu Val Arg Ser Pro Gln Leu
        2115                2120                2125            
His Gly Ala Pro Leu Gly Gly Thr Pro Thr Leu Ser Pro Pro Leu Cys
    2130                2135                2140                
Ser Pro Asn Gly Tyr Leu Gly Ser Leu Lys Pro Gly Val Gln Gly Lys
2145                2150                2155                2160
Lys Val Arg Lys Pro Ser Ser Lys Gly Leu Ala Cys Gly Ser Lys Glu
                2165                2170                2175    
Ala Lys Asp Leu Lys Ala Arg Arg Lys Lys Ser Gln Asp Gly Lys Gly
            2180                2185                2190        
Cys Leu Leu Asp Ser Ser Gly Met Leu Ser Pro Val Asp Ser Leu Glu
        2195                2200                2205            
Ser Pro His Gly Tyr Leu Ser Asp Val Ala Ser Pro Pro Leu Leu Pro
    2210                2215                2220                
Ser Pro Phe Gln Gln Ser Pro Ser Val Pro Leu Asn His Leu Pro Gly
2225                2230                2235                2240
Met Pro Asp Thr His Leu Gly Ile Gly His Leu Asn Val Ala Ala Lys
                2245                2250                2255    
Pro Glu Met Ala Ala Leu Gly Gly Gly Gly Arg Leu Ala Phe Glu Thr
            2260                2265                2270        
Gly Pro Pro Arg Leu Ser His Leu Pro Val Ala Ser Gly Thr Ser Thr
        2275                2280                2285            
Val Leu Gly Ser Ser Ser Gly Gly Ala Leu Asn Phe Thr Val Gly Gly
    2290                2295                2300                
Ser Thr Ser Leu Asn Gly Gln Cys Glu Trp Leu Ser Arg Leu Gln Ser
2305                2310                2315                2320
Gly Met Val Pro Asn Gln Tyr Asn Pro Leu Arg Gly Ser Val Ala Pro
                2325                2330                2335    
Gly Pro Leu Ser Thr Gln Ala Pro Ser Leu Gln His Gly Met Val Gly
            2340                2345                2350        
Pro Leu His Ser Ser Leu Ala Ala Ser Ala Leu Ser Gln Met Met Ser
        2355                2360                2365            
Tyr Gln Gly Leu Pro Ser Thr Arg Leu Ala Thr Gln Pro His Leu Val
    2370                2375                2380                
Gln Thr Gln Gln Val Gln Pro Gln Asn Leu Gln Met Gln Gln Gln Asn
2385                2390                2395                2400
Leu Gln Pro Ala Asn Ile Gln Gln Gln Gln Ser Leu Gln Pro Pro Pro
                2405                2410                2415    
Pro Pro Pro Gln Pro His Leu Gly Val Ser Ser Ala Ala Ser Gly His
            2420                2425                2430        
Leu Gly Arg Ser Phe Leu Ser Gly Glu Pro Ser Gln Ala Asp Val Gln
        2435                2440                2445            
Pro Leu Gly Pro Ser Ser Leu Ala Val His Thr Ile Leu Pro Gln Glu
    2450                2455                2460                
Ser Pro Ala Leu Pro Thr Ser Leu Pro Ser Ser Leu Val Pro Pro Val
2465                2470                2475                2480
Thr Ala Ala Gln Phe Leu Thr Pro Pro Ser Gln His Ser Tyr Ser Ser
                2485                2490                2495    
Pro Val Asp Asn Thr Pro Ser His Gln Leu Gln Val Pro Glu His Pro
            2500                2505                2510        
Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser
        2515                2520                2525            
Pro His Ser Asn Val Ser Asp Trp Ser Glu Gly Val Ser Ser Pro Pro
    2530                2535                2540                
Thr Ser Met Gln Ser Gln Ile Ala Arg Ile Pro Glu Ala Phe Lys
2545                2550                2555                


<210> 6342
<211> 424
<212> PRT
<213> Homo sapiens

<400> 6342
Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser
 1               5                  10                  15      
Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln
            20                  25                  30          
Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn
        35                  40                  45              
Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln
    50                  55                  60                  
Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser
65                  70                  75                  80  
Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln
                85                  90                  95      
Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg
            100                 105                 110         
Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn
        115                 120                 125             
Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly
    130                 135                 140                 
Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met
145                 150                 155                 160 
Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val
                165                 170                 175     
Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val
            180                 185                 190         
Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val
        195                 200                 205             
Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His
    210                 215                 220                 
Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp
225                 230                 235                 240 
Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe
                245                 250                 255     
Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe
            260                 265                 270         
Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu
        275                 280                 285             
Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser
    290                 295                 300                 
Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg
305                 310                 315                 320 
Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser
                325                 330                 335     
Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu
            340                 345                 350         
Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu
        355                 360                 365             
Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr
    370                 375                 380                 
Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg
385                 390                 395                 400 
Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr
                405                 410                 415     
Ser Lys Pro Phe Ala Asp Leu Tyr
            420                 


<210> 6343
<211> 424
<212> PRT
<213> Homo sapiens

<400> 6343
Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser
 1               5                  10                  15      
Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln
            20                  25                  30          
Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn
        35                  40                  45              
Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln
    50                  55                  60                  
Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser
65                  70                  75                  80  
Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln
                85                  90                  95      
Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg
            100                 105                 110         
Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn
        115                 120                 125             
Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly
    130                 135                 140                 
Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met
145                 150                 155                 160 
Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val
                165                 170                 175     
Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val
            180                 185                 190         
Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val
        195                 200                 205             
Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His
    210                 215                 220                 
Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp
225                 230                 235                 240 
Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe
                245                 250                 255     
Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe
            260                 265                 270         
Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu
        275                 280                 285             
Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser
    290                 295                 300                 
Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg
305                 310                 315                 320 
Pro Val Gly Met Asp Thr His Trp Asp His Val Ser Arg Leu Cys Ser
                325                 330                 335     
Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu
            340                 345                 350         
Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu
        355                 360                 365             
Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr
    370                 375                 380                 
Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg
385                 390                 395                 400 
Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr
                405                 410                 415     
Ser Lys Pro Phe Ala Asp Leu Tyr
            420                 


<210> 6344
<211> 245
<212> PRT
<213> Homo sapiens

<400> 6344
Met Gly Arg Leu Asp Gly Lys Val Ile Ile Leu Thr Ala Ala Ala Gln
 1               5                  10                  15      
Gly Ile Gly Gln Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys
            20                  25                  30          
Val Ile Ala Thr Asp Ile Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys
        35                  40                  45              
Tyr Pro Gly Ile Gln Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gln
    50                  55                  60                  
Ile Asp Gln Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn
65                  70                  75                  80  
Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys
                85                  90                  95      
Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met
            100                 105                 110         
Ile Lys Ala Phe Leu Pro Lys Met Leu Ala Gln Lys Ser Gly Asn Ile
        115                 120                 125             
Ile Asn Met Ser Ser Val Ala Ser Ser Val Lys Gly Val Val Asn Arg
    130                 135                 140                 
Cys Val Tyr Ser Thr Thr Lys Ala Ala Val Ile Gly Leu Thr Lys Ser
145                 150                 155                 160 
Val Ala Ala Asp Phe Ile Gln Gln Gly Ile Arg Cys Asn Cys Val Cys
                165                 170                 175     
Pro Gly Thr Val Asp Thr Pro Ser Leu Gln Glu Arg Ile Gln Ala Arg
            180                 185                 190         
Gly Asn Pro Glu Glu Ala Arg Asn Asp Phe Leu Lys Arg Gln Lys Thr
        195                 200                 205             
Gly Arg Phe Ala Thr Ala Glu Glu Ile Ala Met Leu Cys Val Tyr Leu
    210                 215                 220                 
Ala Ser Asp Glu Ser Ala Tyr Val Thr Gly Asn Pro Val Ile Ile Asp
225                 230                 235                 240 
Gly Gly Trp Ser Leu
                245 


<210> 6345
<211> 173
<212> PRT
<213> Homo sapiens

<400> 6345
Met Gly Arg Leu Asp Gly Lys Val Ile Ile Leu Thr Ala Ala Ala Gln
 1               5                  10                  15      
Gly Ile Gly Gln Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys
            20                  25                  30          
Val Ile Ala Thr Asp Ile Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys
        35                  40                  45              
Tyr Pro Gly Ile Gln Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gln
    50                  55                  60                  
Ile Asp Gln Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn
65                  70                  75                  80  
Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys
                85                  90                  95      
Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met
            100                 105                 110         
Ile Lys Ala Phe Leu Pro Lys Met Leu Ala Gln Lys Ser Gly Asn Ile
        115                 120                 125             
Ile Asn Met Ser Ser Val Ala Ser Ser Val Lys Gly Gly Ser Val Ser
    130                 135                 140                 
Phe Arg Gly Leu Arg Cys Ser Tyr Thr His Ile Ile Lys Ser Ser Ala
145                 150                 155                 160 
Phe Gly Asn Arg His Ser Arg Asp Tyr Asn Phe Lys Tyr
                165                 170             


<210> 6346
<211> 998
<212> PRT
<213> Homo sapiens

<400> 6346
Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile
 1               5                  10                  15      
Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu
            20                  25                  30          
Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile
        35                  40                  45              
Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn
    50                  55                  60                  
Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn
65                  70                  75                  80  
Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln
                85                  90                  95      
Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu
            100                 105                 110         
Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr
        115                 120                 125             
Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val
    130                 135                 140                 
Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu
145                 150                 155                 160 
Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro
                165                 170                 175     
Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys
            180                 185                 190         
Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile
        195                 200                 205             
Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe
    210                 215                 220                 
Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu
225                 230                 235                 240 
Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp
                245                 250                 255     
Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys
            260                 265                 270         
Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser
        275                 280                 285             
Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys
    290                 295                 300                 
Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro
305                 310                 315                 320 
Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln
                325                 330                 335     
Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser
            340                 345                 350         
Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu
        355                 360                 365             
Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser
    370                 375                 380                 
Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val
385                 390                 395                 400 
Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu
                405                 410                 415     
Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala
            420                 425                 430         
Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly
        435                 440                 445             
Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln
    450                 455                 460                 
Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr
465                 470                 475                 480 
Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys
                485                 490                 495     
Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val
            500                 505                 510         
Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro
        515                 520                 525             
Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu
    530                 535                 540                 
Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val
545                 550                 555                 560 
Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe
                565                 570                 575     
Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly
            580                 585                 590         
Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr
        595                 600                 605             
Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe
    610                 615                 620                 
Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly
625                 630                 635                 640 
Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly
                645                 650                 655     
Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr
            660                 665                 670         
Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln
        675                 680                 685             
Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly
    690                 695                 700                 
Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp
705                 710                 715                 720 
Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val
                725                 730                 735     
Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met
            740                 745                 750         
Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser
        755                 760                 765             
Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu
    770                 775                 780                 
Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val
785                 790                 795                 800 
Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala
                805                 810                 815     
Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr
            820                 825                 830         
Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala
        835                 840                 845             
Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly
    850                 855                 860                 
Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg
865                 870                 875                 880 
Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn
                885                 890                 895     
Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser
            900                 905                 910         
Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val
        915                 920                 925             
Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe
    930                 935                 940                 
Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile
945                 950                 955                 960 
Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys
                965                 970                 975     
Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His
            980                 985                 990         
Gly Thr Gly Ile Gln Val
        995             


<210> 6347
<211> 824
<212> PRT
<213> Homo sapiens

<400> 6347
Met Leu Phe Ser Trp Arg Glu Asp Pro Gly Ala Gln Cys Leu Leu Leu
 1               5                  10                  15      
Ser Leu Leu Leu Leu Ala Ala Ser Glu Val Gly Ser Gly Gln Leu His
            20                  25                  30          
Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile
        35                  40                  45              
Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe
    50                  55                  60                  
Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln
65                  70                  75                  80  
Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg
            100                 105                 110         
Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Val Phe Pro Met Ala Val Lys Asn Leu Phe Ile Ser Glu
    130                 135                 140                 
Ser Arg Gln Pro Gly Ser Arg Phe Ser Leu Glu Gly Ala Ser Asp Ala
145                 150                 155                 160 
Asp Ile Gly Thr Asn Ser Leu Leu Thr Tyr Ser Leu Asp Ser Thr Glu
                165                 170                 175     
Tyr Phe Thr Leu Asp Val Lys Arg Asn Asp Glu Glu Ile Lys Ser Leu
            180                 185                 190         
Gly Leu Val Leu Lys Lys Asn Leu Asn Arg Glu Asp Thr Pro Lys His
        195                 200                 205             
Tyr Leu Leu Ile Thr Ala Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly
    210                 215                 220                 
Thr Thr Gln Leu Lys Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro
225                 230                 235                 240 
Ala Phe Glu Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Ala Pro
                245                 250                 255     
Asn Gly Thr Leu Val Val Thr Val Asn Ala Thr Asp Leu Asp Glu Gly
            260                 265                 270         
Val Asn Lys Asp Ile Ala Tyr Ser Phe Asn Thr Asp Met Ser Ala Asp
        275                 280                 285             
Ile Leu Ser Lys Phe His Leu Asp Pro Val Asn Gly Gln Ile Ser Val
    290                 295                 300                 
Lys Gly Asn Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Gln Val
305                 310                 315                 320 
Glu Ala Thr Asp Lys Gly Asn Pro Pro Met Ser Asp His Cys Thr Val
                325                 330                 335     
Leu Leu Glu Ile Val Asp Ile Asn Asp Asn Val Pro Glu Leu Val Ile
            340                 345                 350         
Gln Ser Leu Ser Leu Pro Val Leu Glu Asp Ser Pro Leu Ser Thr Val
        355                 360                 365             
Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln
    370                 375                 380                 
Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr
385                 390                 395                 400 
Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Pro Leu Asp Arg Glu
                405                 410                 415     
Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser
            420                 425                 430         
Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val
        435                 440                 445             
Asn Asp Asn Ala Pro Ala Phe Ser Gln Ser Glu Tyr Thr Val Phe Val
    450                 455                 460                 
Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg
465                 470                 475                 480 
Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu
                485                 490                 495     
Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala
            500                 505                 510         
Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu
        515                 520                 525             
Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro
    530                 535                 540                 
Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp
545                 550                 555                 560 
Asn Ala Pro Ala Leu Leu Met Pro Arg Val Gly Gly Ile Gly Gly Ala
                565                 570                 575     
Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala
            580                 585                 590         
Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser
        595                 600                 605             
Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val
    610                 615                 620                 
Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Val
625                 630                 635                 640 
Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu
                645                 650                 655     
Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser
            660                 665                 670         
Gly Gln Ala Pro Lys Ala Ser Ser Gln Ala Ser Ala Gly Ala Thr Gly
        675                 680                 685             
Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Val Ala Ile
    690                 695                 700                 
Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala
705                 710                 715                 720 
Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Asp Cys Gly Pro Gly Lys
                725                 730                 735     
Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln
            740                 745                 750         
Gln Arg Gln Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Thr Asp
        755                 760                 765             
Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Ile Ser Arg Asp
    770                 775                 780                 
Arg Glu Glu Lys Gln Asp Val Asp Val Asp Leu Ser Ala Lys Val Ser
785                 790                 795                 800 
Asn Phe Tyr Leu Phe Phe Pro Lys Cys Leu Cys Phe Ser Phe Leu Asn
                805                 810                 815     
Val Ser Thr Pro Leu Glu Ile His
            820                 


<210> 6348
<211> 950
<212> PRT
<213> Homo sapiens

<400> 6348
Met Leu Phe Ser Trp Arg Glu Asp Pro Gly Ala Gln Cys Leu Leu Leu
 1               5                  10                  15      
Ser Leu Leu Leu Leu Ala Ala Ser Glu Val Gly Ser Gly Gln Leu His
            20                  25                  30          
Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile
        35                  40                  45              
Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe
    50                  55                  60                  
Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln
65                  70                  75                  80  
Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg
            100                 105                 110         
Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Val Phe Pro Met Ala Val Lys Asn Leu Phe Ile Ser Glu
    130                 135                 140                 
Ser Arg Gln Pro Gly Ser Arg Phe Ser Leu Glu Gly Ala Ser Asp Ala
145                 150                 155                 160 
Asp Ile Gly Thr Asn Ser Leu Leu Thr Tyr Ser Leu Asp Ser Thr Glu
                165                 170                 175     
Tyr Phe Thr Leu Asp Val Lys Arg Asn Asp Glu Glu Ile Lys Ser Leu
            180                 185                 190         
Gly Leu Val Leu Lys Lys Asn Leu Asn Arg Glu Asp Thr Pro Lys His
        195                 200                 205             
Tyr Leu Leu Ile Thr Ala Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly
    210                 215                 220                 
Thr Thr Gln Leu Lys Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro
225                 230                 235                 240 
Ala Phe Glu Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Ala Pro
                245                 250                 255     
Asn Gly Thr Leu Val Val Thr Val Asn Ala Thr Asp Leu Asp Glu Gly
            260                 265                 270         
Val Asn Lys Asp Ile Ala Tyr Ser Phe Asn Thr Asp Met Ser Ala Asp
        275                 280                 285             
Ile Leu Ser Lys Phe His Leu Asp Pro Val Asn Gly Gln Ile Ser Val
    290                 295                 300                 
Lys Gly Asn Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Gln Val
305                 310                 315                 320 
Glu Ala Thr Asp Lys Gly Asn Pro Pro Met Ser Asp His Cys Thr Val
                325                 330                 335     
Leu Leu Glu Ile Val Asp Ile Asn Asp Asn Val Pro Glu Leu Val Ile
            340                 345                 350         
Gln Ser Leu Ser Leu Pro Val Leu Glu Asp Ser Pro Leu Ser Thr Val
        355                 360                 365             
Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln
    370                 375                 380                 
Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr
385                 390                 395                 400 
Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Pro Leu Asp Arg Glu
                405                 410                 415     
Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser
            420                 425                 430         
Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val
        435                 440                 445             
Asn Asp Asn Ala Pro Ala Phe Ser Gln Ser Glu Tyr Thr Val Phe Val
    450                 455                 460                 
Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg
465                 470                 475                 480 
Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu
                485                 490                 495     
Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala
            500                 505                 510         
Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu
        515                 520                 525             
Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro
    530                 535                 540                 
Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp
545                 550                 555                 560 
Asn Ala Pro Ala Leu Leu Met Pro Arg Val Gly Gly Ile Gly Gly Ala
                565                 570                 575     
Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala
            580                 585                 590         
Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser
        595                 600                 605             
Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val
    610                 615                 620                 
Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Val
625                 630                 635                 640 
Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu
                645                 650                 655     
Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser
            660                 665                 670         
Gly Gln Ala Pro Lys Ala Ser Ser Gln Ala Ser Ala Gly Ala Thr Gly
        675                 680                 685             
Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Val Ala Ile
    690                 695                 700                 
Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala
705                 710                 715                 720 
Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Asp Cys Gly Pro Gly Lys
                725                 730                 735     
Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln
            740                 745                 750         
Gln Arg Gln Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Thr Asp
        755                 760                 765             
Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Ile Ser Arg Asp
    770                 775                 780                 
Arg Glu Glu Lys Gln Asp Val Asp Val Asp Leu Ser Ala Lys Pro Arg
785                 790                 795                 800 
Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met
                805                 810                 815     
His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro
            820                 825                 830         
Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu
        835                 840                 845             
Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser
    850                 855                 860                 
Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly
865                 870                 875                 880 
Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile
                885                 890                 895     
Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp
            900                 905                 910         
Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys
        915                 920                 925             
Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr
    930                 935                 940                 
Thr Asp Asn Ser Asp Gln
945                 950 


<210> 6349
<211> 439
<212> PRT
<213> Homo sapiens

<400> 6349
Ala Ala Ala Gly Pro Ser Pro Ser Pro Gly Ala Gly Thr Met Val Leu
 1               5                  10                  15      
Ser Val Pro Val Ile Ala Leu Gly Ala Thr Leu Gly Thr Ala Thr Ser
            20                  25                  30          
Ile Leu Ala Leu Cys Gly Val Thr Cys Leu Cys Arg His Met His Pro
        35                  40                  45              
Lys Lys Gly Leu Leu Pro Arg Asp Gln Asp Pro Asp Leu Glu Lys Ala
    50                  55                  60                  
Lys Pro Ser Leu Leu Gly Ser Ala Gln Gln Phe Asn Val Lys Lys Ser
65                  70                  75                  80  
Thr Glu Pro Val Gln Pro Arg Ala Leu Leu Lys Phe Pro Asp Ile Tyr
                85                  90                  95      
Gly Pro Arg Pro Ala Val Thr Ala Pro Glu Val Ile Asn Tyr Ala Asp
            100                 105                 110         
Tyr Ser Leu Arg Ser Thr Glu Glu Pro Thr Ala Pro Ala Ser Pro Gln
        115                 120                 125             
Pro Pro Asn Asp Ser Arg Leu Lys Arg Gln Val Thr Glu Glu Leu Phe
    130                 135                 140                 
Ile Leu Pro Gln Asn Gly Val Val Glu Asp Val Cys Val Met Glu Thr
145                 150                 155                 160 
Trp Asn Pro Glu Lys Ala Ala Ser Trp Asn Gln Ala Pro Lys Leu His
                165                 170                 175     
Tyr Cys Leu Asp Tyr Asp Cys Gln Lys Ala Glu Leu Phe Val Thr Arg
            180                 185                 190         
Leu Glu Ala Val Thr Ser Asn His Asp Gly Gly Cys Asp Cys Tyr Val
        195                 200                 205             
Gln Gly Ser Val Ala Asn Arg Thr Gly Ser Val Glu Ala Gln Thr Ala
    210                 215                 220                 
Leu Lys Lys Arg Gln Leu His Thr Thr Trp Glu Glu Gly Leu Val Leu
225                 230                 235                 240 
Pro Leu Ala Glu Glu Glu Leu Pro Thr Ala Thr Leu Thr Leu Thr Leu
                245                 250                 255     
Arg Thr Cys Asp Arg Phe Ser Arg His Ser Val Ala Gly Glu Leu Arg
            260                 265                 270         
Leu Gly Leu Asp Gly Thr Ser Val Pro Leu Gly Ala Ala Gln Trp Gly
        275                 280                 285             
Glu Leu Lys Thr Ser Ala Lys Glu Pro Ser Ala Gly Ala Gly Glu Val
    290                 295                 300                 
Leu Leu Ser Ile Ser Tyr Leu Pro Ala Ala Asn Arg Leu Leu Val Val
305                 310                 315                 320 
Leu Ile Lys Ala Lys Asn Leu His Ser Asn Gln Ser Lys Glu Leu Leu
                325                 330                 335     
Gly Lys Asp Val Ser Val Lys Val Thr Leu Lys His Gln Ala Arg Lys
            340                 345                 350         
Leu Lys Lys Lys Gln Thr Lys Arg Ala Lys His Lys Ile Asn Pro Val
        355                 360                 365             
Trp Asn Glu Met Ile Met Phe Glu Leu Pro Asp Asp Leu Leu Gln Ala
    370                 375                 380                 
Ser Ser Val Glu Leu Glu Val Leu Gly Gln Asp Asp Ser Gly Gln Ser
385                 390                 395                 400 
Cys Ala Leu Gly His Cys Ser Leu Gly Leu His Thr Ser Gly Ser Glu
                405                 410                 415     
Arg Ser His Trp Glu Glu Met Leu Lys Asn Pro Arg Arg Gln Ile Ala
            420                 425                 430         
Met Trp His Gln Leu His Leu
        435                 


<210> 6350
<211> 541
<212> PRT
<213> Homo sapiens

<400> 6350
Met Thr Thr Pro Ala Gly Ser Gly Ser Gly Phe Gly Ser Val Ser Trp
 1               5                  10                  15      
Trp Gly Leu Ser Pro Ala Leu Asp Leu Gln Ala Glu Ser Pro Pro Val
            20                  25                  30          
Asp Pro Asp Ser Gln Ala Asp Thr Val His Ser Asn Pro Glu Leu Asp
        35                  40                  45              
Val Leu Leu Leu Gly Ser Val Asp Gly Arg His Leu Leu Arg Thr Leu
    50                  55                  60                  
Ser Arg Ala Lys Phe Trp Pro Arg Arg Arg Phe Asn Phe Phe Val Leu
65                  70                  75                  80  
Glu Asn Asn Leu Glu Ala Val Ala Arg His Met Leu Ile Phe Ser Leu
                85                  90                  95      
Ala Leu Glu Glu Pro Glu Lys Met Gly Leu Gln Glu Arg Ser Glu Thr
            100                 105                 110         
Phe Leu Glu Val Trp Gly Asn Ala Leu Leu Arg Pro Pro Val Ala Ala
        115                 120                 125             
Phe Val Arg Ala Gln Ala Asp Leu Leu Ala His Leu Val Pro Glu Pro
    130                 135                 140                 
Asp Arg Leu Glu Glu Gln Leu Pro Trp Leu Ser Leu Arg Ala Leu Lys
145                 150                 155                 160 
Phe Arg Glu Arg Asp Ala Leu Glu Ala Val Phe Arg Phe Trp Ala Gly
                165                 170                 175     
Gly Glu Lys Gly Pro Gln Ala Phe Pro Met Ser Arg Leu Trp Asp Ser
            180                 185                 190         
Arg Leu Arg His Tyr Leu Gly Ser Arg Tyr Asp Ala Arg Arg Gly Val
        195                 200                 205             
Ser Asp Trp Asp Leu Arg Met Lys Leu His Asp Arg Gly Ala Gln Val
    210                 215                 220                 
Ile His Pro Gln Glu Phe Arg Arg Trp Arg Asp Thr Gly Val Ala Phe
225                 230                 235                 240 
Glu Leu Arg Asp Ser Ser Ala Tyr His Val Pro Asn Arg Thr Leu Ala
                245                 250                 255     
Ser Gly Arg Leu Leu Ser Tyr Arg Gly Glu Arg Val Ala Ala Arg Gly
            260                 265                 270         
Tyr Trp Gly Asp Ile Ala Thr Gly Pro Phe Val Ala Phe Gly Ile Glu
        275                 280                 285             
Ala Asp Asp Glu Ser Leu Leu Arg Thr Ser Asn Gly Gln Pro Val Lys
    290                 295                 300                 
Thr Ala Gly Glu Ile Thr Gln His Asn Val Thr Glu Leu Leu Arg Asp
305                 310                 315                 320 
Val Ala Ala Trp Gly Arg Ala Arg Ala Thr Gly Gly Asp Leu Glu Glu
                325                 330                 335     
Gln Gln His Ala Glu Gly Ser Pro Glu Pro Gly Thr Pro Ala Ala Pro
            340                 345                 350         
Thr Pro Glu Ser Phe Thr Val His Phe Leu Pro Leu Asn Ser Ala Gln
        355                 360                 365             
Thr Leu His His Lys Ser Cys Tyr Asn Gly Arg Phe Gln Leu Leu Tyr
    370                 375                 380                 
Val Ala Cys Gly Met Val His Leu Leu Ile Pro Glu Leu Gly Ala Cys
385                 390                 395                 400 
Val Ala Pro Gly Gly Asn Leu Ile Val Glu Leu Ala Arg Tyr Leu Val
                405                 410                 415     
Asp Val Arg Gln Glu Gln Leu Gln Gly Phe Asn Thr Arg Val Arg Glu
            420                 425                 430         
Leu Ala Gln Ala Ala Gly Phe Ala Pro Gln Thr Gly Ala Arg Pro Ser
        435                 440                 445             
Glu Thr Phe Ala Arg Phe Cys Lys Ser Gln Glu Ser Ala Leu Gly Asn
    450                 455                 460                 
Thr Val Pro Ala Val Glu Pro Gly Thr Pro Pro Leu Asp Ile Leu Ala
465                 470                 475                 480 
Gln Pro Leu Glu Ala Ser Asn Pro Ala Leu Glu Gly Leu Thr Gln Pro
                485                 490                 495     
Leu Gln Gly Gly Thr Pro His Cys Glu Pro Cys Gln Leu Pro Ser Glu
            500                 505                 510         
Ser Pro Gly Ser Leu Ser Glu Val Leu Ala Gln Pro Gln Gly Ala Leu
        515                 520                 525             
Ala Pro Pro Asn Cys Glu Ser Asp Ser Lys Thr Gly Val
    530                 535                 540     


<210> 6351
<211> 608
<212> PRT
<213> Homo sapiens

<400> 6351
Met Leu Pro Leu Leu Asp Ser Ser Lys Arg Ala Gly Thr Leu Gly Ser
 1               5                  10                  15      
Gly Cys Gly Val Pro Arg Val His Ser Ala Ala Leu Ser Arg Glu Glu
            20                  25                  30          
Gly Ala Ser Arg Asp Ile Trp Arg Ile Lys Val Trp Ala Arg Val Met
        35                  40                  45              
Thr Thr Pro Ala Gly Ser Gly Ser Gly Phe Gly Ser Val Ser Trp Trp
    50                  55                  60                  
Gly Leu Ser Pro Ala Leu Asp Leu Gln Ala Glu Arg Asp Ala Thr Val
65                  70                  75                  80  
Asp Ala Leu Pro Thr Thr Met Val Pro Gln Pro Ala Val Ile Leu Pro
                85                  90                  95      
Gly Pro Pro Val Asp Pro Asp Ser Gln Ala Asp Thr Val His Ser Asn
            100                 105                 110         
Pro Glu Leu Asp Val Leu Leu Leu Gly Ser Val Asp Gly Arg His Leu
        115                 120                 125             
Leu Arg Thr Leu Ser Arg Ala Lys Phe Trp Pro Arg Arg Arg Phe Asn
    130                 135                 140                 
Phe Phe Val Leu Glu Asn Asn Leu Glu Ala Val Ala Arg His Met Leu
145                 150                 155                 160 
Ile Phe Ser Leu Ala Leu Glu Glu Pro Glu Lys Met Gly Leu Gln Glu
                165                 170                 175     
Arg Ser Glu Thr Phe Leu Glu Val Trp Gly Asn Ala Leu Leu Arg Pro
            180                 185                 190         
Pro Val Ala Ala Phe Val Arg Ala Gln Ala Asp Leu Leu Ala His Leu
        195                 200                 205             
Val Pro Glu Pro Asp Arg Leu Glu Glu Gln Leu Pro Trp Leu Ser Leu
    210                 215                 220                 
Arg Ala Leu Lys Phe Arg Glu Arg Asp Ala Leu Glu Ala Val Phe Arg
225                 230                 235                 240 
Phe Trp Ala Gly Gly Glu Lys Gly Pro Gln Ala Phe Pro Met Ser Arg
                245                 250                 255     
Leu Trp Asp Ser Arg Leu Arg His Tyr Leu Gly Ser Arg Tyr Asp Ala
            260                 265                 270         
Arg Arg Gly Val Ser Asp Trp Asp Leu Arg Met Lys Leu His Asp Arg
        275                 280                 285             
Gly Ala Gln Val Ile His Pro Gln Glu Phe Arg Arg Trp Arg Asp Thr
    290                 295                 300                 
Gly Val Ala Phe Glu Leu Arg Asp Ser Ser Ala Tyr His Val Pro Asn
305                 310                 315                 320 
Arg Thr Leu Ala Ser Gly Arg Leu Leu Ser Tyr Arg Gly Glu Arg Val
                325                 330                 335     
Ala Ala Arg Gly Tyr Trp Gly Asp Ile Ala Thr Gly Pro Phe Val Ala
            340                 345                 350         
Phe Gly Ile Glu Ala Asp Asp Glu Ser Leu Leu Arg Thr Ser Asn Gly
        355                 360                 365             
Gln Pro Val Lys Thr Ala Gly Glu Ile Thr Gln His Asn Val Thr Glu
    370                 375                 380                 
Leu Leu Arg Asp Val Ala Ala Trp Gly Arg Ala Arg Ala Thr Gly Gly
385                 390                 395                 400 
Asp Leu Glu Glu Gln Gln His Ala Glu Gly Ser Pro Glu Pro Gly Thr
                405                 410                 415     
Pro Ala Pro Thr Pro Glu Ser Phe Thr Val His Phe Leu Pro Leu Asn
            420                 425                 430         
Ser Ala Gln Thr Leu His His Lys Ser Cys Tyr Asn Gly Arg Phe Gln
        435                 440                 445             
Leu Leu Tyr Val Ala Cys Gly Met Val His Leu Leu Ile Pro Glu Leu
    450                 455                 460                 
Gly Ala Cys Val Ala Pro Gly Gly Asn Leu Ile Val Glu Leu Ala Arg
465                 470                 475                 480 
Tyr Leu Val Asp Val Arg Gln Glu Gln Leu Gln Gly Phe Asn Thr Arg
                485                 490                 495     
Val Arg Glu Leu Ala Gln Ala Ala Gly Phe Ala Pro Gln Thr Gly Ala
            500                 505                 510         
Arg Pro Ser Glu Thr Phe Ala Arg Phe Cys Lys Ser Gln Glu Ser Ala
        515                 520                 525             
Leu Gly Asn Thr Val Pro Ala Val Glu Pro Gly Thr Pro Pro Leu Asp
    530                 535                 540                 
Ile Leu Ala Gln Pro Leu Glu Ala Ser Asn Pro Ala Leu Glu Gly Leu
545                 550                 555                 560 
Thr Gln Pro Leu Gln Gly Gly Thr Pro His Cys Glu Pro Cys Gln Leu
                565                 570                 575     
Pro Ser Glu Ser Pro Gly Ser Leu Ser Glu Val Leu Ala Gln Pro Gln
            580                 585                 590         
Gly Ala Leu Ala Pro Pro Asn Cys Glu Ser Asp Ser Lys Thr Gly Val
        595                 600                 605             


<210> 6352
<211> 326
<212> PRT
<213> Homo sapiens

<400> 6352
Ser Gly Thr Gly Lys Met Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln
 1               5                  10                  15      
Ile Ala Leu Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr
            20                  25                  30          
Arg Glu Leu Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Val Asp
        35                  40                  45              
Tyr Met Gly Ala Ser Cys His Ala Cys Ile Arg Gly Thr Asn Val Arg
    50                  55                  60                  
Ala Glu Val Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly
65                  70                  75                  80  
Thr Pro Ser Cys Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro
                85                  90                  95      
Lys Tyr Ile Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser
            100                 105                 110         
Arg Gly Phe Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser
        115                 120                 125             
Asn Thr Gln Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu
    130                 135                 140                 
Glu Val Ile Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys
145                 150                 155                 160 
Lys Glu Glu Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val
                165                 170                 175     
Glu Arg Glu Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr
            180                 185                 190         
Leu Thr Ile Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val
        195                 200                 205             
Asp Trp Leu Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala
    210                 215                 220                 
Met His Gly Asp Met Asp Gln Lys Glu Arg Asp Val Ile Thr Arg Glu
225                 230                 235                 240 
Phe Arg Ser Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala
                245                 250                 255     
Arg Gly Ile Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu
            260                 265                 270         
Pro Thr Asn Arg Glu Asn Tyr Ile His Arg Ile Ser Arg Gly Gly Gln
        275                 280                 285             
Phe Gly Arg Lys Asp Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys
    290                 295                 300                 
Arg Thr Leu Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu
305                 310                 315                 320 
Met Pro Pro Met Leu Leu
                325     


<210> 6353
<211> 406
<212> PRT
<213> Homo sapiens

<400> 6353
Met Pro Arg Ala Gly Arg Ser Leu Gly Arg Ser Ala Gly Thr Ser Pro
 1               5                  10                  15      
Pro Ser Ser Gly Ala Ser Pro Lys Ala Gly Gln Ser Lys Ile Ser Ala
            20                  25                  30          
Val Ser Arg Leu Leu Leu Ala Ser Pro Arg Ala His Gly Pro Ser Ala
        35                  40                  45              
Ser Thr Thr Lys Thr Leu Ser Phe Ser Thr Lys Ser Leu Pro Gln Ala
    50                  55                  60                  
Val Gly Gln Gly Ser Ser Ser Pro Pro Gly Gly Lys His Thr Pro Trp
65                  70                  75                  80  
Ser Thr Gln Ser Leu Ser Arg Asn Arg Ser Ser Gly Leu Ala Ser Lys
                85                  90                  95      
Leu Pro Leu Arg Ala Val Ser Gly Arg Ile Ser Glu Leu Leu Gln Gly
            100                 105                 110         
Gly Ala Gly Ala Arg Gly Leu Gln Leu Arg Ala Gly Pro Glu Ala Glu
        115                 120                 125             
Ala Arg Gly Gly Ala Leu Ala Glu Asp Glu Pro Ala Ala Ala His Leu
    130                 135                 140                 
Leu Pro Ser Pro Tyr Ser Lys Ile Thr Pro Pro Arg Arg Pro His Arg
145                 150                 155                 160 
Cys Ser Ser Gly His Gly Ser Asp Asn Ser Ser Val Leu Ser Gly Glu
                165                 170                 175     
Leu Pro Pro Ala Met Gly Lys Thr Ala Leu Phe Tyr His Ser Gly Gly
            180                 185                 190         
Ser Ser Gly Tyr Glu Ser Val Met Arg Asp Ser Glu Ala Thr Gly Ser
        195                 200                 205             
Ala Ser Ser Ala Gln Asp Ser Thr Ser Glu Asn Ser Ser Ser Val Gly
    210                 215                 220                 
Gly Arg Cys Arg Ser Leu Lys Thr Pro Lys Lys Arg Ser Asn Pro Gly
225                 230                 235                 240 
Ser Gln Arg Arg Arg Leu Ile Pro Ala Leu Ser Leu Asp Thr Ser Ser
                245                 250                 255     
Pro Val Arg Lys Pro Pro Asn Ser Thr Gly Val Arg Trp Val Asp Gly
            260                 265                 270         
Pro Leu Arg Ser Ser Pro Arg Gly Leu Gly Glu Pro Phe Glu Ile Lys
        275                 280                 285             
Val Tyr Glu Ile Asp Asp Val Glu Arg Leu Gln Arg Arg Arg Gly Gly
    290                 295                 300                 
Ala Ser Lys Glu Ala Met Cys Phe Asn Ala Lys Leu Lys Ile Leu Glu
305                 310                 315                 320 
His Arg Gln Gln Arg Ile Ala Glu Val Arg Ala Lys Tyr Glu Trp Leu
                325                 330                 335     
Met Lys Glu Leu Glu Ala Thr Lys Gln Tyr Leu Met Leu Asp Pro Asn
            340                 345                 350         
Lys Trp Leu Ser Glu Phe Asp Leu Glu Gln Val Trp Glu Leu Asp Ser
        355                 360                 365             
Leu Glu Tyr Leu Glu Ala Leu Glu Cys Val Thr Glu Arg Leu Glu Ser
    370                 375                 380                 
Arg Val Asn Phe Cys Lys Ala His Leu Met Met Ile Thr Cys Phe Asp
385                 390                 395                 400 
Ile Thr Ser Arg Arg Arg
                405     


<210> 6354
<211> 1682
<212> PRT
<213> Homo sapiens

<400> 6354
Pro Gly Trp Met His Arg Ala Val Asp Pro Pro Gly Ala Arg Ala Ala
 1               5                  10                  15      
Arg Glu Ala Phe Ala Leu Gly Gly Leu Ser Cys Ala Gly Ala Trp Ser
            20                  25                  30          
Ser Cys Pro Pro His Pro Pro Pro Arg Ser Ala Trp Leu Pro Gly Gly
        35                  40                  45              
Arg Cys Ser Ala Ser Ile Gly Gln Pro Pro Leu Pro Ala Pro Leu Pro
    50                  55                  60                  
Pro Ser His Gly Ser Ser Ser Gly His Pro Ser Lys Pro Tyr Tyr Ala
65                  70                  75                  80  
Pro Gly Ala Pro Thr Pro Arg Pro Leu His Gly Lys Leu Glu Ser Leu
                85                  90                  95      
His Gly Cys Val Gln Ala Leu Leu Arg Glu Pro Ala Gln Pro Gly Leu
            100                 105                 110         
Trp Glu Gln Leu Gly Gln Leu Tyr Glu Ser Glu His Asp Ser Glu Glu
        115                 120                 125             
Ala Thr Arg Cys Tyr His Ser Ala Leu Arg Tyr Gly Gly Ser Phe Ala
    130                 135                 140                 
Glu Leu Gly Pro Arg Ile Gly Arg Leu Gln Gln Ala Gln Leu Trp Asn
145                 150                 155                 160 
Phe His Thr Gly Ser Cys Gln His Arg Ala Lys Val Leu Pro Pro Leu
                165                 170                 175     
Glu Gln Val Trp Asn Leu Leu His Leu Glu His Lys Arg Asn Tyr Gly
            180                 185                 190         
Ala Lys Arg Gly Gly Pro Pro Val Lys Arg Ala Ala Glu Pro Pro Val
        195                 200                 205             
Val Gln Pro Val Pro Pro Ala Ala Leu Ser Gly Pro Ser Gly Glu Glu
    210                 215                 220                 
Gly Leu Ser Pro Gly Gly Lys Arg Arg Arg Gly Cys Asn Ser Glu Gln
225                 230                 235                 240 
Thr Gly Leu Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro Leu Pro Pro
                245                 250                 255     
Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Leu Ala Thr Ser Pro
            260                 265                 270         
Pro Phe Gln Leu Thr Lys Pro Gly Leu Trp Ser Thr Leu His Gly Asp
        275                 280                 285             
Ala Trp Gly Pro Glu Arg Lys Gly Ser Ala Pro Pro Glu Arg Gln Glu
    290                 295                 300                 
Gln Arg His Ser Leu Pro His Pro Tyr Pro Tyr Pro Ala Pro Ala Tyr
305                 310                 315                 320 
Thr Ala His Pro Pro Gly His Arg Leu Val Pro Ala Ala Pro Pro Gly
                325                 330                 335     
Pro Gly Pro Arg Pro Pro Gly Ala Glu Ser His Gly Cys Leu Pro Ala
            340                 345                 350         
Thr Arg Pro Pro Gly Ser Asp Leu Arg Glu Ser Arg Val Gln Arg Ser
        355                 360                 365             
Arg Met Asp Ser Ser Val Ser Pro Ala Ala Thr Thr Ala Cys Val Pro
    370                 375                 380                 
Tyr Ala Pro Ser Arg Pro Pro Gly Leu Pro Gly Thr Thr Thr Ser Ser
385                 390                 395                 400 
Ser Ser Ser Ser Ser Ser Asn Thr Gly Leu Arg Gly Val Glu Pro Asn
                405                 410                 415     
Pro Gly Ile Pro Gly Ala Asp His Tyr Gln Thr Pro Ala Leu Glu Val
            420                 425                 430         
Ser His His Gly Arg Leu Gly Pro Ser Ala His Ser Ser Arg Lys Pro
        435                 440                 445             
Phe Leu Gly Ala Pro Ala Ala Thr Pro His Leu Ser Leu Pro Pro Gly
    450                 455                 460                 
Pro Ser Ser Pro Pro Pro Pro Pro Cys Pro Arg Leu Leu Arg Pro Pro
465                 470                 475                 480 
Pro Pro Pro Ala Trp Leu Lys Gly Pro Ala Cys Arg Ala Ala Arg Glu
                485                 490                 495     
Asp Gly Glu Ile Leu Glu Glu Leu Phe Phe Gly Thr Glu Gly Pro Pro
            500                 505                 510         
Arg Pro Ala Pro Pro Pro Leu Pro His Arg Glu Gly Phe Leu Gly Pro
        515                 520                 525             
Pro Ala Ser Arg Phe Ser Val Gly Thr Gln Asp Ser His Thr Pro Pro
    530                 535                 540                 
Thr Pro Pro Thr Pro Thr Thr Ser Ser Ser Asn Ser Asn Ser Gly Ser
545                 550                 555                 560 
His Ser Ser Ser Pro Ala Gly Pro Val Ser Phe Pro Pro Pro Pro Tyr
                565                 570                 575     
Leu Ala Arg Ser Ile Asp Pro Leu Pro Arg Pro Pro Ser Pro Ala Gln
            580                 585                 590         
Asn Pro Gln Asp Pro Pro Leu Val Pro Leu Thr Leu Ala Leu Pro Pro
        595                 600                 605             
Ala Pro Pro Ser Ser Cys His Gln Asn Thr Ser Gly Ser Phe Arg Arg
    610                 615                 620                 
Pro Glu Ser Pro Arg Pro Arg Val Ser Phe Pro Lys Thr Pro Glu Val
625                 630                 635                 640 
Gly Pro Gly Pro Pro Pro Gly Pro Leu Ser Lys Ala Pro Gln Pro Val
                645                 650                 655     
Pro Pro Gly Val Gly Glu Leu Pro Ala Arg Gly Pro Arg Leu Phe Asp
            660                 665                 670         
Phe Pro Pro Thr Pro Leu Glu Asp Gln Phe Glu Glu Pro Ala Glu Phe
        675                 680                 685             
Lys Ile Leu Pro Asp Gly Leu Ala Asn Ile Met Lys Met Leu Asp Glu
    690                 695                 700                 
Ser Ile Arg Lys Glu Glu Glu Gln Gln Gln His Glu Ala Gly Val Ala
705                 710                 715                 720 
Pro Gln Pro Pro Leu Lys Glu Pro Phe Ala Ser Leu Gln Ser Pro Phe
                725                 730                 735     
Pro Thr Asp Thr Ala Pro Thr Thr Thr Ala Pro Ala Val Ala Val Thr
            740                 745                 750         
Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Thr Gln Glu Glu Glu
        755                 760                 765             
Lys Lys Pro Pro Pro Ala Leu Pro Pro Pro Pro Pro Leu Ala Lys Phe
    770                 775                 780                 
Pro Pro Pro Ser Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ser Pro
785                 790                 795                 800 
Ala Ser Leu Leu Lys Ser Leu Ala Ser Val Leu Glu Gly Gln Lys Tyr
                805                 810                 815     
Cys Tyr Arg Gly Thr Gly Ala Ala Val Ser Thr Arg Pro Gly Pro Leu
            820                 825                 830         
Pro Thr Thr Gln Tyr Ser Pro Gly Pro Pro Ser Gly Ala Thr Ala Leu
        835                 840                 845             
Pro Pro Thr Ser Ala Ala Pro Ser Ala Gln Gly Ser Pro Gln Pro Ser
    850                 855                 860                 
Ala Ser Ser Ser Ser Gln Phe Ser Thr Ser Gly Gly Pro Trp Ala Arg
865                 870                 875                 880 
Glu Arg Arg Ala Gly Glu Glu Pro Val Pro Gly Pro Met Thr Pro Thr
                885                 890                 895     
Gln Pro Pro Pro Pro Leu Ser Leu Pro Pro Ala Arg Ser Glu Ser Glu
            900                 905                 910         
Val Leu Glu Glu Ile Ser Arg Ala Cys Glu Thr Leu Val Glu Arg Val
        915                 920                 925             
Gly Arg Ser Ala Thr Asp Pro Ala Asp Pro Val Asp Thr Ala Glu Pro
    930                 935                 940                 
Ala Asp Ser Gly Thr Glu Arg Leu Leu Pro Pro Ala Gln Ala Lys Glu
945                 950                 955                 960 
Glu Ala Gly Gly Val Ala Ala Val Ser Gly Ser Cys Lys Arg Arg Gln
                965                 970                 975     
Lys Glu His Gln Lys Glu His Arg Arg His Arg Arg Ala Cys Lys Asp
            980                 985                 990         
Ser Val Gly Arg Arg Pro Arg Glu Gly Arg Ala Lys Ala Lys Ala Lys
        995                 1000                1005            
Val Pro Lys Glu Lys Ser Arg Arg Val Leu Gly Asn Leu Asp Leu Gln
    1010                1015                1020                
Ser Glu Glu Ile Gln Gly Arg Glu Lys Ser Arg Pro Asp Leu Gly Gly
1025                1030                1035                1040
Ala Ser Lys Ala Lys Pro Pro Thr Ala Pro Ala Pro Pro Ser Ala Pro
                1045                1050                1055    
Ala Pro Ser Ala Gln Pro Thr Pro Pro Ser Ala Ser Val Pro Gly Lys
            1060                1065                1070        
Lys Ala Arg Glu Glu Ala Pro Gly Pro Pro Gly Val Ser Arg Ala Asp
        1075                1080                1085            
Met Leu Lys Leu Arg Ser Leu Ser Glu Gly Pro Pro Lys Glu Leu Lys
    1090                1095                1100                
Ile Arg Leu Ile Lys Val Glu Ser Gly Asp Lys Glu Thr Phe Ile Ala
1105                1110                1115                1120
Ser Glu Val Glu Glu Arg Arg Leu Arg Met Ala Asp Leu Thr Ile Ser
                1125                1130                1135    
His Cys Ala Ala Asp Val Val Arg Ala Ser Arg Asn Ala Lys Val Lys
            1140                1145                1150        
Gly Lys Phe Arg Glu Ser Tyr Leu Ser Pro Ala Gln Ser Val Lys Pro
        1155                1160                1165            
Lys Ile Asn Thr Glu Glu Lys Leu Pro Arg Glu Lys Leu Asn Pro Pro
    1170                1175                1180                
Thr Pro Ser Ile Tyr Leu Glu Ser Lys Arg Asp Ala Phe Ser Pro Val
1185                1190                1195                1200
Leu Leu Gln Phe Cys Thr Asp Pro Arg Asn Pro Ile Thr Val Ile Arg
                1205                1210                1215    
Gly Leu Ala Gly Ser Leu Arg Leu Asn Leu Gly Leu Phe Ser Thr Lys
            1220                1225                1230        
Thr Leu Val Glu Ala Ser Gly Glu His Thr Val Glu Val Arg Thr Gln
        1235                1240                1245            
Val Gln Gln Pro Ser Asp Glu Asn Trp Asp Leu Thr Gly Thr Arg Gln
    1250                1255                1260                
Ile Trp Pro Cys Glu Ser Ser Arg Ser His Thr Thr Ile Ala Lys Tyr
1265                1270                1275                1280
Ala Gln Tyr Gln Ala Ser Ser Phe Gln Glu Ser Leu Gln Glu Glu Lys
                1285                1290                1295    
Glu Ser Glu Asp Glu Glu Ser Glu Glu Pro Asp Ser Thr Thr Gly Thr
            1300                1305                1310        
Pro Pro Ser Ser Ala Pro Asp Pro Lys Asn His His Ile Ile Lys Phe
        1315                1320                1325            
Gly Thr Asn Ile Asp Leu Ser Asp Ala Lys Arg Trp Lys Pro Gln Leu
    1330                1335                1340                
Gln Glu Leu Leu Lys Leu Pro Ala Phe Met Arg Val Thr Ser Thr Gly
1345                1350                1355                1360
Asn Met Leu Ser His Val Gly His Thr Ile Leu Gly Met Asn Thr Val
                1365                1370                1375    
Gln Leu Tyr Met Lys Val Pro Gly Ser Arg Thr Pro Gly His Gln Glu
            1380                1385                1390        
Asn Asn Asn Phe Cys Ser Val Asn Ile Asn Ile Gly Pro Gly Asp Cys
        1395                1400                1405            
Glu Trp Phe Ala Val His Glu His Tyr Trp Glu Thr Ile Ser Ala Phe
    1410                1415                1420                
Cys Asp Arg His Gly Val Asp Tyr Leu Thr Gly Ser Trp Trp Pro Ile
1425                1430                1435                1440
Leu Asp Asp Leu Tyr Ala Ser Asn Ile Pro Val Tyr Arg Phe Val Gln
                1445                1450                1455    
Arg Pro Gly Asp Leu Val Trp Ile Asn Ala Gly Thr Val His Trp Val
            1460                1465                1470        
Gln Ala Thr Gly Trp Cys Asn Asn Ile Ala Trp Asn Val Gly Pro Leu
        1475                1480                1485            
Thr Ala Tyr Gln Tyr Gln Leu Ala Leu Glu Arg Tyr Glu Trp Asn Glu
    1490                1495                1500                
Val Lys Asn Val Lys Ser Ile Val Pro Met Ile His Val Ser Trp Asn
1505                1510                1515                1520
Val Ala Arg Thr Val Lys Ile Ser Asp Pro Asp Leu Phe Lys Met Ile
                1525                1530                1535    
Lys Phe Cys Leu Leu Gln Ser Met Lys His Cys Gln Val Gln Arg Glu
            1540                1545                1550        
Ser Leu Val Arg Ala Gly Lys Lys Ile Ala Tyr Gln Gly Arg Val Lys
        1555                1560                1565            
Asp Glu Pro Ala Tyr Tyr Cys Asn Glu Cys Asp Val Glu Val Phe Asn
    1570                1575                1580                
Ile Leu Phe Val Thr Ser Glu Asn Gly Ser Arg Asn Thr Tyr Leu Val
1585                1590                1595                1600
His Cys Glu Gly Cys Ala Arg Arg Arg Ser Ala Gly Leu Gln Gly Val
                1605                1610                1615    
Val Val Leu Glu Gln Tyr Arg Thr Glu Glu Leu Ala Gln Ala Tyr Asp
            1620                1625                1630        
Ala Phe Thr Leu Val Arg Ala Arg Arg Ala Arg Gly Gln Arg Arg Arg
        1635                1640                1645            
Ala Leu Gly Gln Ala Ala Gly Thr Gly Phe Gly Ser Pro Ala Ala Pro
    1650                1655                1660                
Phe Pro Glu Pro Pro Pro Ala Phe Ser Pro Gln Ala Pro Ala Ser Thr
1665                1670                1675                1680
Ser Arg
        


<210> 6355
<211> 1253
<212> PRT
<213> Homo sapiens

<400> 6355
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
 1               5                  10                  15      
Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
            20                  25                  30          
Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe
        35                  40                  45              
Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
    50                  55                  60                  
Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu
65                  70                  75                  80  
Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr
                85                  90                  95      
Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr
            100                 105                 110         
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
        115                 120                 125             
Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys
    130                 135                 140                 
Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro
145                 150                 155                 160 
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
                165                 170                 175     
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
            180                 185                 190         
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
        195                 200                 205             
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
    210                 215                 220                 
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro
225                 230                 235                 240 
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
                245                 250                 255     
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
            260                 265                 270         
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
        275                 280                 285             
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu
    290                 295                 300                 
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305                 310                 315                 320 
Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
                325                 330                 335     
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
            340                 345                 350         
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
        355                 360                 365             
Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile
    370                 375                 380                 
Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met
385                 390                 395                 400 
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
                405                 410                 415     
Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp
            420                 425                 430         
Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
        435                 440                 445             
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp
    450                 455                 460                 
Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly
465                 470                 475                 480 
Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe
                485                 490                 495     
Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu
            500                 505                 510         
Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile
        515                 520                 525             
Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp
    530                 535                 540                 
Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu
545                 550                 555                 560 
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu
                565                 570                 575     
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
            580                 585                 590         
Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val
        595                 600                 605             
Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His
    610                 615                 620                 
Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp
625                 630                 635                 640 
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
                645                 650                 655     
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
            660                 665                 670         
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
        675                 680                 685             
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser
    690                 695                 700                 
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705                 710                 715                 720 
Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys
                725                 730                 735     
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
            740                 745                 750         
Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val
        755                 760                 765             
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
    770                 775                 780                 
Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785                 790                 795                 800 
Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro
                805                 810                 815     
Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys
            820                 825                 830         
Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr
        835                 840                 845             
Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg
    850                 855                 860                 
His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val
865                 870                 875                 880 
Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln
                885                 890                 895     
Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser
            900                 905                 910         
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
        915                 920                 925             
Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His
    930                 935                 940                 
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu
945                 950                 955                 960 
Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg
                965                 970                 975     
Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln
            980                 985                 990         
Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
        995                 1000                1005            
Gly Gly Thr Met Ala Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser
    1010                1015                1020                
Ala Thr Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025                1030                1035                1040
Gly Gln Cys Asn Phe Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu
                1045                1050                1055    
Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln
            1060                1065                1070        
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
        1075                1080                1085            
His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys Thr
    1090                1095                1100                
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105                1110                1115                1120
Gly Trp Phe Ile Gly Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val
                1125                1130                1135    
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
            1140                1145                1150        
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
        1155                1160                1165            
Lys Asp Glu Thr Phe Gly Glu Tyr Ser Asp Asn Glu Glu Lys Ala Phe
    1170                1175                1180                
Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys Pro Leu Gly Ser
1185                1190                1195                1200
Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp Val Gln Phe Asn
                1205                1210                1215    
Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu
            1220                1225                1230        
Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser Pro Ile Asn Pro
        1235                1240                1245            
Ala Val Ala Leu Glu
    1250            


<210> 6356
<211> 1257
<212> PRT
<213> Homo sapiens

<400> 6356
Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro
 1               5                  10                  15      
Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met
            20                  25                  30          
Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe
        35                  40                  45              
Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu
    50                  55                  60                  
Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu
65                  70                  75                  80  
Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr
                85                  90                  95      
Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr
            100                 105                 110         
Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile
        115                 120                 125             
Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys
    130                 135                 140                 
Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro
145                 150                 155                 160 
Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile
                165                 170                 175     
Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn
            180                 185                 190         
Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile
        195                 200                 205             
Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro
    210                 215                 220                 
Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro
225                 230                 235                 240 
Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln
                245                 250                 255     
Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro
            260                 265                 270         
Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val
        275                 280                 285             
Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu
    290                 295                 300                 
Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser
305                 310                 315                 320 
Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu
                325                 330                 335     
His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu
            340                 345                 350         
Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile
        355                 360                 365             
Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile
    370                 375                 380                 
Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met
385                 390                 395                 400 
Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn
                405                 410                 415     
Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp
            420                 425                 430         
Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys
        435                 440                 445             
Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp
    450                 455                 460                 
Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly
465                 470                 475                 480 
Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe
                485                 490                 495     
Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu
            500                 505                 510         
Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile
        515                 520                 525             
Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp
    530                 535                 540                 
Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu
545                 550                 555                 560 
Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu
                565                 570                 575     
Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val
            580                 585                 590         
Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val
        595                 600                 605             
Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His
    610                 615                 620                 
Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp
625                 630                 635                 640 
His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu
                645                 650                 655     
Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln
            660                 665                 670         
Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg
        675                 680                 685             
Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser
    690                 695                 700                 
Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp
705                 710                 715                 720 
Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys
                725                 730                 735     
Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val
            740                 745                 750         
Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val
        755                 760                 765             
Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr
    770                 775                 780                 
Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro
785                 790                 795                 800 
Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro
                805                 810                 815     
Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys
            820                 825                 830         
Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr
        835                 840                 845             
Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg
    850                 855                 860                 
His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val
865                 870                 875                 880 
Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln
                885                 890                 895     
Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser
            900                 905                 910         
Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys
        915                 920                 925             
Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His
    930                 935                 940                 
Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu
945                 950                 955                 960 
Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg
                965                 970                 975     
Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln
            980                 985                 990         
Leu Gln Ala Thr Thr Lys Glu Gly Pro Gly Glu Ala Ile Val Arg Glu
        995                 1000                1005            
Gly Gly Thr Met Ala Leu Ser Gly Ile Ser Asp Phe Gly Asn Ile Ser
    1010                1015                1020                
Ala Thr Ala Gly Glu Asn Tyr Ser Val Val Ser Trp Val Pro Lys Glu
1025                1030                1035                1040
Gly Gln Cys Asn Phe Arg Phe His Ile Leu Phe Lys Ala Leu Gly Glu
                1045                1050                1055    
Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn Gln
            1060                1065                1070        
Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu Ile
        1075                1080                1085            
His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys Thr
    1090                1095                1100                
Asn Gly Thr Gly Arg Val Arg Leu Pro Pro Ala Gly Phe Ala Thr Glu
1105                1110                1115                1120
Gly Trp Phe Ile Gly Phe Val Ser Ala Ile Ile Leu Leu Leu Leu Val
                1125                1130                1135    
Leu Leu Ile Leu Cys Phe Ile Lys Arg Ser Lys Gly Gly Lys Tyr Ser
            1140                1145                1150        
Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu Ala Arg Pro Met
        1155                1160                1165            
Lys Asp Glu Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Asn Glu
    1170                1175                1180                
Glu Lys Ala Phe Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys
1185                1190                1195                1200
Pro Leu Gly Ser Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp
                1205                1210                1215    
Val Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys
            1220                1225                1230        
Lys Glu Lys Glu Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser
        1235                1240                1245            
Pro Ile Asn Pro Ala Val Ala Leu Glu
    1250                1255        


<210> 6357
<211> 391
<212> PRT
<213> Homo sapiens

<400> 6357
Met Leu Arg Pro Gly Gly Ala Glu Glu Ala Ala Gln Leu Pro Leu Arg
 1               5                  10                  15      
Arg Ala Ser Ala Pro Val Pro Val Pro Ser Pro Ala Ala Pro Asp Gly
            20                  25                  30          
Ser Arg Ala Ser Ala Arg Leu Gly Leu Ala Cys Leu Leu Leu Leu Leu
        35                  40                  45              
Leu Leu Thr Leu Pro Ala Arg Val Asp Thr Ser Trp Trp Tyr Ile Gly
    50                  55                  60                  
Ala Leu Gly Ala Arg Val Ile Cys Asp Asn Ile Pro Gly Leu Val Ser
65                  70                  75                  80  
Arg Gln Arg Gln Leu Cys Gln Arg Tyr Pro Asp Ile Met Arg Ser Val
                85                  90                  95      
Gly Glu Gly Ala Arg Glu Trp Ile Arg Glu Cys Gln His Gln Phe Arg
            100                 105                 110         
His His Arg Trp Asn Cys Thr Thr Leu Asp Arg Asp His Thr Val Phe
        115                 120                 125             
Gly Arg Val Met Leu Arg Ser Ser Arg Glu Ala Ala Phe Val Tyr Ala
    130                 135                 140                 
Ile Ser Ser Ala Gly Val Val His Ala Ile Thr Arg Ala Cys Ser Gln
145                 150                 155                 160 
Gly Glu Leu Ser Val Cys Ser Cys Asp Pro Tyr Thr Arg Gly Arg His
                165                 170                 175     
His Asp Gln Arg Gly Asp Phe Asp Trp Gly Gly Cys Ser Asp Asn Ile
            180                 185                 190         
His Tyr Gly Val Arg Phe Ala Lys Ala Phe Val Asp Ala Lys Glu Lys
        195                 200                 205             
Arg Leu Lys Asp Ala Arg Ala Leu Met Asn Leu His Asn Asn Arg Cys
    210                 215                 220                 
Gly Arg Thr Ala Val Arg Arg Phe Leu Lys Leu Glu Cys Lys Cys His
225                 230                 235                 240 
Gly Val Ser Gly Ser Cys Thr Leu Arg Thr Cys Trp Arg Ala Leu Ser
                245                 250                 255     
Asp Phe Arg Arg Thr Gly Asp Tyr Leu Arg Arg Arg Tyr Asp Gly Ala
            260                 265                 270         
Val Gln Val Met Ala Thr Gln Asp Gly Ala Asn Phe Thr Ala Ala Arg
        275                 280                 285             
Gln Gly Tyr Arg Arg Ala Thr Arg Thr Asp Leu Val Tyr Phe Asp Asn
    290                 295                 300                 
Ser Pro Asp Tyr Cys Val Leu Asp Lys Ala Ala Gly Ser Leu Gly Thr
305                 310                 315                 320 
Ala Gly Arg Val Cys Ser Lys Thr Ser Lys Gly Thr Asp Gly Cys Glu
                325                 330                 335     
Ile Met Cys Cys Gly Arg Gly Tyr Asp Thr Thr Arg Val Thr Arg Val
            340                 345                 350         
Thr Gln Cys Glu Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys Lys
        355                 360                 365             
Glu Cys Arg Asn Thr Val Asp Val His Thr Cys Lys Ala Pro Lys Lys
    370                 375                 380                 
Ala Glu Trp Leu Asp Gln Thr
385                 390     


<210> 6358
<211> 372
<212> PRT
<213> Homo sapiens

<400> 6358
Met Leu Asp Gly Leu Gly Val Val Ala Ile Ser Ile Phe Gly Ile Gln
 1               5                  10                  15      
Leu Lys Thr Glu Gly Ser Leu Arg Thr Ala Val Pro Gly Ile Pro Thr
            20                  25                  30          
Gln Ser Ala Phe Asn Lys Cys Leu Gln Arg Tyr Ile Gly Ala Leu Gly
        35                  40                  45              
Ala Arg Val Ile Cys Asp Asn Ile Pro Gly Leu Val Ser Arg Gln Arg
    50                  55                  60                  
Gln Leu Cys Gln Arg Tyr Pro Asp Ile Met Arg Ser Val Gly Glu Gly
65                  70                  75                  80  
Ala Arg Glu Trp Ile Arg Glu Cys Gln His Gln Phe Arg His His Arg
                85                  90                  95      
Trp Asn Cys Thr Thr Leu Asp Arg Asp His Thr Val Phe Gly Arg Val
            100                 105                 110         
Met Leu Arg Ser Ser Arg Glu Ala Ala Phe Val Tyr Ala Ile Ser Ser
        115                 120                 125             
Ala Gly Val Val His Ala Ile Thr Arg Ala Cys Ser Gln Gly Glu Leu
    130                 135                 140                 
Ser Val Cys Ser Cys Asp Pro Tyr Thr Arg Gly Arg His His Asp Gln
145                 150                 155                 160 
Arg Gly Asp Phe Asp Trp Gly Gly Cys Ser Asp Asn Ile His Tyr Gly
                165                 170                 175     
Val Arg Phe Ala Lys Ala Phe Val Asp Ala Lys Glu Lys Arg Leu Lys
            180                 185                 190         
Asp Ala Arg Ala Leu Met Asn Leu His Asn Asn Arg Cys Gly Arg Thr
        195                 200                 205             
Ala Val Arg Arg Phe Leu Lys Leu Glu Cys Lys Cys His Gly Val Ser
    210                 215                 220                 
Gly Ser Cys Thr Leu Arg Thr Cys Trp Arg Ala Leu Ser Asp Phe Arg
225                 230                 235                 240 
Arg Thr Gly Asp Tyr Leu Arg Arg Arg Tyr Asp Gly Ala Val Gln Val
                245                 250                 255     
Met Ala Thr Gln Asp Gly Ala Asn Phe Thr Ala Ala Arg Gln Gly Tyr
            260                 265                 270         
Arg Arg Ala Thr Arg Thr Asp Leu Val Tyr Phe Asp Asn Ser Pro Asp
        275                 280                 285             
Tyr Cys Val Leu Asp Lys Ala Ala Gly Ser Leu Gly Thr Ala Gly Arg
    290                 295                 300                 
Val Cys Ser Lys Thr Ser Lys Gly Thr Asp Gly Cys Glu Ile Met Cys
305                 310                 315                 320 
Cys Gly Arg Gly Tyr Asp Thr Thr Arg Val Thr Arg Val Thr Gln Cys
                325                 330                 335     
Glu Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys Lys Glu Cys Arg
            340                 345                 350         
Asn Thr Val Asp Val His Thr Cys Lys Ala Pro Lys Lys Ala Glu Trp
        355                 360                 365             
Leu Asp Gln Thr
    370         


<210> 6359
<211> 741
<212> PRT
<213> Homo sapiens

<400> 6359
Met Arg Arg Tyr Arg Thr Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly
 1               5                  10                  15      
Arg Ala Cys Gly Gly Pro Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp
            20                  25                  30          
Met Cys Pro Val Asp Gly Ser Trp Gly Ser Trp His Ser Trp Ser Gln
        35                  40                  45              
Cys Ser Ala Ser Cys Gly Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys
    50                  55                  60                  
Asp His Pro Val Pro Val Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr
65                  70                  75                  80  
Thr Gln Val Thr Arg Cys Asn Val Gln Ala Cys Pro Gly Gly Pro Gln
                85                  90                  95      
Arg Ala Arg Gly Ser Val Ile Gly Asn Ile Asn Asp Val Glu Phe Gly
            100                 105                 110         
Ile Ala Phe Leu Asn Ala Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr
        115                 120                 125             
Arg Ile Ile Arg Ala Lys Ile Thr Asn Val Pro Arg Ser Leu Gly Ser
    130                 135                 140                 
Ala Met Arg Lys Ile Val Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr
145                 150                 155                 160 
Ala Lys Glu Ile Gly Glu Ala Val Asn Gly Phe Thr Leu Thr Asn Ala
                165                 170                 175     
Val Phe Lys Arg Glu Thr Gln Val Glu Phe Ala Thr Gly Glu Ile Leu
            180                 185                 190         
Gln Met Ser His Ile Ala Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu
        195                 200                 205             
Leu Asp Ile Val Val Ser Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala
    210                 215                 220                 
Glu Val Thr Val Lys Asp Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro
225                 230                 235                 240 
Gly Gln Leu Tyr Ala Tyr Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile
                245                 250                 255     
Ser Ile Pro Tyr Thr Trp Asn His Thr Val Phe Tyr Asp Gln Ala Gln
            260                 265                 270         
Gly Arg Met Pro Phe Leu Val Glu Thr Leu His Ala Ser Ser Val Glu
        275                 280                 285             
Ser Asp Tyr Asn Gln Ile Glu Glu Thr Leu Gly Phe Lys Ile His Ala
    290                 295                 300                 
Ser Ile Ser Lys Gly Asp Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr
305                 310                 315                 320 
Leu Asp Ser Val Gly Pro Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala
                325                 330                 335     
Gly Asn Pro Cys Ser His Ser Cys His Asn Ala Met Gly Thr Tyr Tyr
            340                 345                 350         
Cys Ser Cys Pro Lys Gly Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys
        355                 360                 365             
Gln Asp Ile Asp Glu Cys Ala Leu Gly Arg His Thr Cys His Ala Gly
    370                 375                 380                 
Gln Asp Cys Asp Asn Thr Ile Gly Ser Tyr Arg Cys Val Val Arg Cys
385                 390                 395                 400 
Gly Ser Gly Phe Arg Arg Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile
                405                 410                 415     
Asn Glu Cys Gln Glu Ser Ser Pro Cys His Gln Arg Cys Phe Asn Ala
            420                 425                 430         
Ile Gly Ser Phe His Cys Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly
        435                 440                 445             
Arg Lys Cys Met Asp Val Asn Glu Cys Arg Gln Asn Val Cys Arg Pro
    450                 455                 460                 
Asp Gln His Cys Lys Asn Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu
465                 470                 475                 480 
Cys Pro Asn Gly Met Thr Lys Ala Glu Asn Gly Thr Cys Ile Asp Ile
                485                 490                 495     
Asp Glu Cys Lys Asp Gly Thr His Gln Cys Arg Tyr Asn Gln Ile Cys
            500                 505                 510         
Glu Asn Thr Arg Gly Ser Tyr Arg Cys Val Cys Pro Arg Gly Tyr Arg
        515                 520                 525             
Ser Gln Gly Val Gly Arg Pro Cys Met Asp Ile Asp Glu Cys Glu Asn
    530                 535                 540                 
Thr Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe Gly Ser Tyr Gln
545                 550                 555                 560 
Cys Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn Gly Lys Thr Cys
                565                 570                 575     
Gln Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His Cys Gly Pro Asn
            580                 585                 590         
Arg Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys Ile Asp Thr Pro
        595                 600                 605             
Cys Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly Phe Cys Leu Lys
    610                 615                 620                 
Asn Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser Pro Tyr Ala Leu
625                 630                 635                 640 
Glu Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala Thr Asn Gln Asp
                645                 650                 655     
Leu Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val Met His Pro Arg
            660                 665                 670         
Thr Thr Phe Leu Met Val Asp Glu Glu Gln Thr Val Pro Phe Ala Leu
        675                 680                 685             
Arg Asp Glu Asn Leu Lys Gly Val Val Tyr Thr Thr Arg Pro Leu Arg
    690                 695                 700                 
Glu Ala Glu Thr Tyr Arg Met Arg Val Arg Ala Ser Ser Tyr Ser Ala
705                 710                 715                 720 
Asn Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile Val Tyr Ile Ala Val
                725                 730                 735     
Ser Ala Tyr Pro Tyr
            740     


<210> 6360
<211> 5636
<212> PRT
<213> Homo sapiens

<400> 6360
Met Ile Ser Trp Glu Val Val His Thr Val Phe Leu Phe Ala Leu Leu
 1               5                  10                  15      
Tyr Ser Ser Leu Ala Gln Asp Ala Ser Pro Gln Ser Glu Ile Arg Ala
            20                  25                  30          
Glu Glu Ile Pro Glu Gly Ala Ser Thr Leu Ala Phe Val Phe Asp Val
        35                  40                  45              
Thr Gly Ser Met Tyr Asp Asp Leu Val Gln Val Ile Glu Gly Ala Ser
    50                  55                  60                  
Lys Ile Leu Glu Thr Ser Leu Lys Arg Pro Lys Arg Pro Leu Phe Asn
65                  70                  75                  80  
Phe Ala Leu Val Pro Phe His Asp Pro Glu Ile Gly Pro Val Thr Ile
                85                  90                  95      
Thr Thr Asp Pro Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val
            100                 105                 110         
Gln Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys Ile
        115                 120                 125             
Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr Asp
    130                 135                 140                 
Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu Ile
145                 150                 155                 160 
Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Asp
                165                 170                 175     
Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser Thr
            180                 185                 190         
Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu Val
        195                 200                 205             
Leu Lys Trp Val Glu Glu Ala Val Gln Ala Ser Lys Val His Leu Leu
    210                 215                 220                 
Ser Thr Asp His Leu Glu Gln Ala Val Asn Thr Trp Arg Ile Pro Phe
225                 230                 235                 240 
Asp Pro Ser Leu Lys Glu Val Thr Val Ser Leu Ser Gly Pro Ser Pro
                245                 250                 255     
Met Ile Glu Ile Arg Asn Pro Leu Gly Lys Leu Ile Lys Lys Gly Phe
            260                 265                 270         
Gly Leu His Glu Leu Leu Asn Ile His Asn Ser Ala Lys Val Val Asn
        275                 280                 285             
Val Lys Glu Pro Glu Ala Gly Met Trp Thr Val Lys Thr Ser Ser Ser
    290                 295                 300                 
Gly Arg His Ser Val Arg Ile Thr Gly Leu Ser Thr Ile Asp Phe Arg
305                 310                 315                 320 
Ala Gly Phe Ser Arg Lys Pro Thr Leu Asp Phe Lys Lys Thr Val Ser
                325                 330                 335     
Arg Pro Val Gln Gly Ile Pro Thr Tyr Val Leu Leu Asn Thr Ser Gly
            340                 345                 350         
Ile Ser Thr Pro Ala Arg Ile Asp Leu Leu Glu Leu Leu Ser Ile Ser
        355                 360                 365             
Gly Ser Ser Leu Lys Thr Ile Pro Val Lys Tyr Tyr Pro His Arg Lys
    370                 375                 380                 
Pro Tyr Gly Ile Trp Asn Ile Ser Asp Phe Val Pro Pro Asn Glu Ala
385                 390                 395                 400 
Phe Phe Leu Lys Val Thr Gly Tyr Asp Lys Asp Asp Tyr Leu Phe Gln
                405                 410                 415     
Arg Val Ser Ser Val Ser Phe Ser Ser Ile Val Pro Asp Ala Pro Lys
            420                 425                 430         
Val Thr Met Pro Glu Lys Thr Pro Gly Tyr Tyr Leu Gln Pro Gly Gln
        435                 440                 445             
Ile Pro Cys Ser Val Asp Ser Leu Leu Pro Phe Thr Leu Ser Phe Val
    450                 455                 460                 
Arg Asn Gly Val Thr Leu Gly Val Asp Gln Tyr Leu Lys Glu Ser Ala
465                 470                 475                 480 
Ser Val Asn Leu Asp Ile Ala Lys Val Thr Leu Ser Asp Glu Gly Phe
                485                 490                 495     
Tyr Glu Cys Ile Ala Val Ser Ser Ala Gly Thr Gly Arg Ala Gln Thr
            500                 505                 510         
Phe Phe Asp Val Ser Glu Pro Pro Pro Val Ile Gln Val Pro Asn Asn
        515                 520                 525             
Val Thr Val Thr Pro Gly Glu Arg Ala Val Leu Thr Cys Leu Ile Ile
    530                 535                 540                 
Ser Ala Val Asp Tyr Asn Leu Thr Trp Gln Arg Asn Asp Arg Asp Val
545                 550                 555                 560 
Arg Leu Ala Glu Pro Ala Arg Ile Arg Thr Leu Ala Asn Leu Ser Leu
                565                 570                 575     
Glu Leu Lys Ser Val Lys Phe Asn Asp Ala Gly Glu Tyr His Cys Met
            580                 585                 590         
Val Ser Ser Glu Gly Gly Ser Ser Ala Ala Ser Val Phe Leu Thr Val
        595                 600                 605             
Gln Glu Pro Pro Lys Val Thr Val Met Pro Lys Asn Gln Ser Phe Thr
    610                 615                 620                 
Gly Gly Ser Glu Val Ser Ile Met Cys Ser Ala Thr Gly Tyr Pro Lys
625                 630                 635                 640 
Pro Lys Ile Ala Trp Thr Val Asn Asp Met Phe Ile Val Gly Ser His
                645                 650                 655     
Arg Tyr Arg Met Thr Ser Asp Gly Thr Leu Phe Ile Lys Asn Ala Ala
            660                 665                 670         
Pro Lys Asp Ala Gly Ile Tyr Gly Cys Leu Ala Ser Asn Ser Ala Gly
        675                 680                 685             
Thr Asp Lys Gln Asn Ser Thr Leu Arg Tyr Ile Glu Ala Pro Lys Leu
    690                 695                 700                 
Met Val Val Gln Ser Glu Leu Leu Val Ala Leu Gly Asp Ile Thr Val
705                 710                 715                 720 
Met Glu Cys Lys Thr Ser Gly Ile Pro Pro Pro Gln Val Lys Trp Phe
                725                 730                 735     
Lys Gly Asp Leu Glu Leu Arg Pro Ser Thr Phe Leu Ile Ile Asp Pro
            740                 745                 750         
Leu Leu Gly Leu Leu Lys Ile Gln Glu Thr Gln Asp Leu Asp Ala Gly
        755                 760                 765             
Asp Tyr Thr Cys Val Ala Ile Asn Glu Ala Gly Arg Ala Thr Gly Lys
    770                 775                 780                 
Ile Thr Leu Asp Val Gly Ser Pro Pro Val Phe Ile Gln Glu Pro Ala
785                 790                 795                 800 
Asp Val Ser Met Glu Ile Gly Ser Asn Val Thr Leu Pro Cys Tyr Val
                805                 810                 815     
Gln Gly Tyr Pro Glu Pro Thr Ile Lys Trp Arg Arg Leu Asp Asn Met
            820                 825                 830         
Pro Ile Phe Ser Arg Pro Phe Ser Val Ser Ser Ile Ser Gln Leu Arg
        835                 840                 845             
Thr Gly Ala Leu Phe Ile Leu Asn Leu Trp Ala Ser Asp Lys Gly Thr
    850                 855                 860                 
Tyr Ile Cys Glu Ala Glu Asn Gln Phe Gly Lys Ile Gln Ser Glu Thr
865                 870                 875                 880 
Thr Val Thr Val Thr Gly Leu Val Ala Pro Leu Ile Gly Ile Ser Pro
                885                 890                 895     
Ser Val Ala Asn Val Ile Glu Gly Gln Gln Leu Thr Leu Pro Cys Thr
            900                 905                 910         
Leu Leu Ala Gly Asn Pro Ile Pro Glu Arg Arg Trp Ile Lys Asn Ser
        915                 920                 925             
Ala Met Leu Leu Gln Asn Pro Tyr Ile Thr Val Arg Ser Asp Gly Ser
    930                 935                 940                 
Leu His Ile Glu Arg Val Gln Leu Gln Asp Gly Gly Glu Tyr Thr Cys
945                 950                 955                 960 
Val Ala Ser Asn Val Ala Gly Thr Asn Asn Lys Thr Thr Ser Val Val
                965                 970                 975     
Val His Val Leu Pro Thr Ile Gln His Gly Gln Gln Ile Leu Ser Thr
            980                 985                 990         
Ile Glu Gly Ile Pro Val Thr Leu Pro Cys Lys Ala Ser Gly Asn Pro
        995                 1000                1005            
Lys Pro Ser Val Ile Trp Ser Lys Lys Gly Glu Leu Ile Ser Thr Ser
    1010                1015                1020                
Ser Ala Lys Phe Ser Ala Gly Ala Asp Gly Ser Leu Tyr Val Val Ser
1025                1030                1035                1040
Pro Gly Gly Glu Glu Ser Gly Glu Tyr Val Cys Thr Ala Thr Asn Thr
                1045                1050                1055    
Ala Gly Tyr Ala Lys Arg Lys Val Gln Leu Thr Val Tyr Val Arg Pro
            1060                1065                1070        
Arg Val Phe Gly Asp Gln Arg Gly Leu Ser Gln Asp Lys Pro Val Glu
        1075                1080                1085            
Ile Ser Val Leu Ala Gly Glu Glu Val Thr Leu Pro Cys Glu Val Lys
    1090                1095                1100                
Ser Leu Pro Pro Pro Ile Ile Thr Trp Ala Lys Glu Thr Gln Leu Ile
1105                1110                1115                1120
Ser Pro Phe Ser Pro Arg His Thr Phe Leu Pro Ser Gly Ser Met Lys
                1125                1130                1135    
Ile Thr Glu Thr Arg Thr Ser Asp Ser Gly Met Tyr Leu Cys Val Ala
            1140                1145                1150        
Thr Asn Ile Ala Gly Asn Val Thr Gln Ala Val Lys Leu Asn Val His
        1155                1160                1165            
Val Pro Pro Lys Ile Gln Arg Gly Pro Lys His Leu Lys Val Gln Val
    1170                1175                1180                
Gly Gln Arg Val Asp Ile Pro Cys Asn Ala Gln Gly Thr Pro Leu Pro
1185                1190                1195                1200
Val Ile Thr Trp Ser Lys Gly Gly Ser Thr Met Leu Val Asp Gly Glu
                1205                1210                1215    
His His Val Ser Asn Pro Asp Gly Thr Leu Ser Ile Asp Gln Ala Thr
            1220                1225                1230        
Pro Ser Asp Ala Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Ala Gly
        1235                1240                1245            
Thr Asp Glu Thr Glu Ile Thr Leu His Val Gln Glu Pro Pro Thr Val
    1250                1255                1260                
Glu Asp Leu Glu Pro Pro Tyr Asn Thr Thr Phe Gln Glu Arg Val Ala
1265                1270                1275                1280
Asn Gln Arg Ile Glu Phe Pro Cys Pro Ala Lys Gly Thr Pro Lys Pro
                1285                1290                1295    
Thr Ile Lys Trp Leu His Asn Gly Arg Glu Leu Thr Gly Arg Glu Pro
            1300                1305                1310        
Gly Ile Ser Ile Leu Glu Asp Gly Thr Leu Leu Val Ile Ala Ser Val
        1315                1320                1325            
Thr Pro Tyr Asp Asn Gly Glu Tyr Ile Cys Val Ala Val Asn Glu Ala
    1330                1335                1340                
Gly Thr Thr Glu Arg Lys Tyr Asn Leu Lys Val His Val Pro Pro Val
1345                1350                1355                1360
Ile Lys Asp Lys Glu Gln Val Thr Asn Val Ser Val Leu Leu Asn Gln
                1365                1370                1375    
Leu Thr Asn Leu Phe Cys Glu Val Glu Gly Thr Pro Ser Pro Ile Ile
            1380                1385                1390        
Met Trp Tyr Lys Asp Asn Val Gln Val Thr Glu Ser Ser Thr Ile Gln
        1395                1400                1405            
Thr Val Asn Asn Gly Lys Ile Leu Lys Leu Phe Arg Ala Thr Pro Glu
    1410                1415                1420                
Asp Ala Gly Arg Tyr Ser Cys Lys Ala Ile Asn Ile Ala Gly Thr Ser
1425                1430                1435                1440
Gln Lys Tyr Phe Asn Ile Asp Val Leu Val Pro Pro Thr Ile Ile Gly
                1445                1450                1455    
Thr Asn Phe Pro Asn Glu Val Ser Val Val Leu Asn Arg Asp Val Ala
            1460                1465                1470        
Leu Glu Cys Gln Val Lys Gly Thr Pro Phe Pro Asp Ile His Trp Phe
        1475                1480                1485            
Lys Asp Gly Lys Pro Leu Phe Leu Gly Asp Pro Asn Val Glu Leu Leu
    1490                1495                1500                
Asp Arg Gly Gln Val Leu His Leu Lys Asn Ala Arg Arg Asn Asp Lys
1505                1510                1515                1520
Gly Arg Tyr Gln Cys Thr Val Ser Asn Ala Ala Gly Lys Gln Ala Lys
                1525                1530                1535    
Asp Ile Lys Leu Thr Ile Tyr Ile Pro Pro Ser Ile Lys Gly Gly Asn
            1540                1545                1550        
Val Thr Thr Asp Ile Ser Val Leu Ile Asn Ser Leu Ile Lys Leu Glu
        1555                1560                1565            
Cys Glu Thr Arg Gly Leu Pro Met Pro Ala Ile Thr Trp Tyr Lys Asp
    1570                1575                1580                
Gly Gln Pro Ile Met Ser Ser Ser Gln Ala Leu Tyr Ile Asp Lys Gly
1585                1590                1595                1600
Gln Tyr Leu His Ile Pro Arg Ala Gln Val Ser Asp Ser Ala Thr Tyr
                1605                1610                1615    
Thr Cys His Val Ala Asn Val Ala Gly Thr Ala Glu Lys Ser Phe His
            1620                1625                1630        
Val Asp Val Tyr Val Pro Pro Met Ile Glu Gly Asn Leu Ala Thr Pro
        1635                1640                1645            
Leu Asn Lys Gln Val Val Ile Ala His Ser Leu Thr Leu Glu Cys Lys
    1650                1655                1660                
Ala Ala Gly Asn Pro Ser Pro Ile Leu Thr Trp Leu Lys Asp Gly Val
1665                1670                1675                1680
Pro Val Lys Ala Asn Asp Asn Ile Arg Ile Glu Ala Gly Gly Lys Lys
                1685                1690                1695    
Leu Glu Ile Met Ser Ala Gln Glu Ile Asp Arg Gly Gln Tyr Ile Cys
            1700                1705                1710        
Val Ala Thr Ser Val Ala Gly Glu Lys Glu Ile Lys Tyr Glu Val Asp
        1715                1720                1725            
Val Leu Val Pro Pro Ala Ile Glu Gly Gly Asp Glu Thr Ser Tyr Phe
    1730                1735                1740                
Ile Val Met Val Asn Asn Leu Leu Glu Leu Asp Cys His Val Thr Gly
1745                1750                1755                1760
Ser Pro Pro Pro Thr Ile Met Trp Leu Lys Asp Gly Gln Leu Ile Asp
                1765                1770                1775    
Glu Arg Asp Gly Phe Lys Ile Leu Leu Asn Gly Arg Lys Leu Val Ile
            1780                1785                1790        
Ala Gln Ala Gln Val Ser Asn Thr Gly Leu Tyr Arg Cys Met Ala Ala
        1795                1800                1805            
Asn Thr Ala Gly Asp His Lys Lys Glu Phe Glu Val Thr Val His Val
    1810                1815                1820                
Pro Pro Thr Ile Lys Ser Ser Gly Leu Ser Glu Arg Val Val Val Lys
1825                1830                1835                1840
Tyr Lys Pro Val Ala Leu Gln Cys Ile Ala Asn Gly Ile Pro Asn Pro
                1845                1850                1855    
Ser Ile Thr Trp Leu Lys Asp Asp Gln Pro Val Asn Thr Ala Gln Gly
            1860                1865                1870        
Asn Leu Lys Ile Gln Ser Ser Gly Arg Val Leu Gln Ile Ala Lys Thr
        1875                1880                1885            
Leu Leu Glu Asp Ala Gly Arg Tyr Thr Cys Val Ala Thr Asn Ala Ala
    1890                1895                1900                
Gly Glu Thr Gln Gln His Ile Gln Leu His Val His Glu Pro Pro Ser
1905                1910                1915                1920
Leu Glu Asp Ala Gly Lys Met Leu Asn Glu Thr Val Leu Val Ser Asn
                1925                1930                1935    
Pro Val Gln Leu Glu Cys Lys Ala Ala Gly Asn Pro Val Pro Val Ile
            1940                1945                1950        
Thr Trp Tyr Lys Asp Asn Arg Leu Leu Ser Gly Ser Thr Ser Met Thr
        1955                1960                1965            
Phe Leu Asn Arg Gly Gln Ile Ile Asp Ile Glu Ser Ala Gln Ile Ser
    1970                1975                1980                
Asp Ala Gly Ile Tyr Lys Cys Val Ala Ile Asn Ser Ala Gly Ala Thr
1985                1990                1995                2000
Glu Leu Phe Tyr Ser Leu Gln Val His Val Ala Pro Ser Ile Ser Gly
                2005                2010                2015    
Ser Asn Asn Met Val Ala Val Val Val Asn Asn Pro Val Arg Leu Glu
            2020                2025                2030        
Cys Glu Ala Arg Gly Ile Pro Ala Pro Ser Leu Thr Trp Leu Lys Asp
        2035                2040                2045            
Gly Ser Pro Val Ser Ser Phe Ser Asn Gly Leu Gln Val Leu Ser Gly
    2050                2055                2060                
Gly Arg Ile Leu Ala Leu Thr Ser Ala Gln Ile Ser Asp Thr Gly Arg
2065                2070                2075                2080
Tyr Thr Cys Val Ala Val Asn Ala Ala Gly Glu Lys Gln Arg Asp Ile
                2085                2090                2095    
Asp Leu Arg Val Tyr Val Pro Pro Asn Ile Met Gly Glu Glu Gln Asn
            2100                2105                2110        
Val Ser Val Leu Ile Ser Gln Ala Val Glu Leu Leu Cys Gln Ser Asp
        2115                2120                2125            
Ala Ile Pro Pro Pro Thr Leu Thr Trp Leu Lys Asp Gly His Pro Leu
    2130                2135                2140                
Leu Lys Lys Pro Gly Leu Ser Ile Ser Glu Asn Arg Ser Val Leu Lys
2145                2150                2155                2160
Ile Glu Asp Ala Gln Val Gln Asp Thr Gly Arg Tyr Thr Cys Glu Ala
                2165                2170                2175    
Thr Asn Val Ala Gly Lys Thr Glu Lys Lys Asn Tyr Asn Val Asn Ile
            2180                2185                2190        
Trp Val Pro Pro Asn Ile Gly Gly Ser Asp Glu Leu Thr Gln Leu Thr
        2195                2200                2205            
Val Ile Glu Gly Asn Leu Ile Ser Leu Leu Cys Glu Ser Ser Gly Ile
    2210                2215                2220                
Pro Pro Pro Asn Leu Ile Trp Lys Lys Lys Gly Ser Pro Val Leu Thr
2225                2230                2235                2240
Asp Ser Met Gly Arg Val Arg Ile Leu Ser Gly Gly Arg Gln Leu Gln
                2245                2250                2255    
Ile Ser Ile Ala Glu Lys Ser Asp Ala Ala Leu Tyr Ser Cys Val Ala
            2260                2265                2270        
Ser Asn Val Ala Gly Thr Ala Lys Lys Glu Tyr Asn Leu Gln Val Tyr
        2275                2280                2285            
Ile Arg Pro Thr Ile Thr Asn Ser Gly Ser His Pro Thr Glu Ile Ile
    2290                2295                2300                
Val Thr Arg Gly Lys Ser Ile Ser Leu Glu Cys Glu Val Gln Gly Ile
2305                2310                2315                2320
Pro Pro Pro Thr Val Thr Trp Met Lys Asp Gly His Pro Leu Ile Lys
                2325                2330                2335    
Ala Lys Gly Val Glu Ile Leu Asp Glu Gly His Ile Leu Gln Leu Lys
            2340                2345                2350        
Asn Ile His Val Ser Asp Thr Gly Arg Tyr Val Cys Val Ala Val Asn
        2355                2360                2365            
Val Ala Gly Met Thr Asp Lys Lys Tyr Asp Leu Ser Val His Ala Pro
    2370                2375                2380                
Pro Ser Ile Ile Gly Asn His Arg Ser Pro Glu Asn Ile Ser Val Val
2385                2390                2395                2400
Glu Lys Asn Ser Val Ser Leu Thr Cys Glu Ala Ser Gly Ile Pro Leu
                2405                2410                2415    
Pro Ser Ile Thr Trp Phe Lys Asp Gly Trp Pro Val Ser Leu Ser Asn
            2420                2425                2430        
Ser Val Arg Ile Leu Ser Gly Gly Arg Met Leu Arg Leu Met Gln Thr
        2435                2440                2445            
Thr Met Glu Asp Ala Gly Gln Tyr Thr Cys Val Val Arg Asn Ala Ala
    2450                2455                2460                
Gly Glu Glu Arg Lys Ile Phe Gly Leu Ser Val Leu Val Pro Pro His
2465                2470                2475                2480
Ile Val Gly Glu Asn Thr Leu Glu Asp Val Lys Val Lys Glu Lys Gln
                2485                2490                2495    
Ser Val Thr Leu Thr Cys Glu Val Thr Gly Asn Pro Val Pro Glu Ile
            2500                2505                2510        
Thr Trp His Lys Asp Gly Gln Pro Leu Gln Glu Asp Glu Ala His His
        2515                2520                2525            
Ile Ile Ser Gly Gly Arg Phe Leu Gln Ile Thr Asn Val Gln Val Pro
    2530                2535                2540                
His Thr Gly Arg Tyr Thr Cys Leu Ala Ser Ser Pro Ala Gly His Lys
2545                2550                2555                2560
Ser Arg Ser Phe Ser Leu Asn Val Phe Val Ser Pro Thr Ile Ala Gly
                2565                2570                2575    
Val Gly Ser Asp Gly Asn Pro Glu Asp Val Thr Val Ile Leu Asn Ser
            2580                2585                2590        
Pro Thr Ser Leu Val Cys Glu Ala Tyr Ser Tyr Pro Pro Ala Thr Ile
        2595                2600                2605            
Thr Trp Phe Lys Asp Gly Thr Pro Leu Glu Ser Asn Arg Asn Ile Arg
    2610                2615                2620                
Ile Leu Pro Gly Gly Arg Thr Leu Gln Ile Leu Asn Ala Gln Glu Asp
2625                2630                2635                2640
Asn Ala Gly Arg Tyr Ser Cys Val Ala Thr Asn Glu Ala Gly Glu Met
                2645                2650                2655    
Ile Lys His Tyr Glu Val Lys Val Tyr Ile Pro Pro Ile Ile Asn Lys
            2660                2665                2670        
Gly Asp Leu Trp Gly Pro Gly Leu Ser Pro Lys Glu Val Lys Ile Lys
        2675                2680                2685            
Val Asn Asn Thr Leu Thr Leu Glu Cys Glu Ala Tyr Ala Ile Pro Ser
    2690                2695                2700                
Ala Ser Leu Ser Trp Tyr Lys Asp Gly Gln Pro Leu Lys Ser Asp Asp
2705                2710                2715                2720
His Val Asn Ile Ala Ala Asn Gly His Thr Leu Gln Ile Lys Glu Ala
                2725                2730                2735    
Gln Ile Ser Asp Thr Gly Arg Tyr Thr Cys Val Ala Ser Asn Ile Ala
            2740                2745                2750        
Gly Glu Asp Glu Leu Asp Phe Asp Val Asn Ile Gln Val Pro Pro Ser
        2755                2760                2765            
Phe Gln Lys Leu Trp Glu Ile Gly Asn Met Leu Asp Thr Gly Arg Asn
    2770                2775                2780                
Gly Glu Ala Lys Asp Val Ile Ile Asn Asn Pro Ile Ser Leu Tyr Cys
2785                2790                2795                2800
Glu Thr Asn Ala Ala Pro Pro Pro Thr Leu Thr Trp Tyr Lys Asp Gly
                2805                2810                2815    
His Pro Leu Thr Ser Ser Asp Lys Val Leu Ile Leu Pro Gly Gly Arg
            2820                2825                2830        
Val Leu Gln Ile Pro Arg Ala Lys Val Glu Asp Ala Gly Arg Tyr Thr
        2835                2840                2845            
Cys Val Ala Val Asn Glu Ala Gly Glu Asp Ser Leu Gln Tyr Asp Val
    2850                2855                2860                
Arg Val Leu Val Pro Pro Ile Ile Lys Gly Ala Asn Ser Asp Leu Pro
2865                2870                2875                2880
Glu Glu Val Thr Val Leu Val Asn Lys Ser Ala Leu Ile Glu Cys Leu
                2885                2890                2895    
Ser Ser Gly Ser Pro Ala Pro Arg Asn Ser Trp Gln Lys Asp Gly Gln
            2900                2905                2910        
Pro Leu Leu Glu Asp Asp His His Lys Phe Leu Ser Asn Gly Arg Ile
        2915                2920                2925            
Leu Gln Ile Leu Asn Thr Gln Ile Thr Asp Ile Gly Arg Tyr Val Cys
    2930                2935                2940                
Val Ala Glu Asn Thr Ala Gly Ser Ala Lys Lys Tyr Phe Asn Leu Asn
2945                2950                2955                2960
Val His Val Pro Pro Ser Val Ile Gly Pro Lys Ser Glu Asn Leu Thr
                2965                2970                2975    
Val Val Val Asn Asn Phe Ile Ser Leu Thr Cys Glu Val Ser Gly Phe
            2980                2985                2990        
Pro Pro Pro Asp Leu Ser Trp Leu Lys Asn Glu Gln Pro Ile Lys Leu
        2995                3000                3005            
Asn Thr Asn Thr Leu Ile Val Pro Gly Gly Arg Thr Leu Gln Ile Ile
    3010                3015                3020                
Arg Ala Lys Val Ser Asp Gly Gly Glu Tyr Thr Cys Ile Ala Ile Asn
3025                3030                3035                3040
Gln Ala Gly Glu Ser Lys Lys Lys Phe Ser Leu Thr Val Tyr Val Pro
                3045                3050                3055    
Pro Ser Ile Lys Asp His Asp Ser Glu Ser Leu Ser Val Val Asn Val
            3060                3065                3070        
Arg Glu Gly Thr Ser Val Ser Leu Glu Cys Glu Ser Asn Ala Val Pro
        3075                3080                3085            
Pro Pro Val Ile Thr Trp Tyr Lys Asn Gly Arg Met Ile Thr Glu Ser
    3090                3095                3100                
Thr His Val Glu Ile Leu Ala Asp Gly Gln Met Leu His Ile Lys Lys
3105                3110                3115                3120
Ala Glu Val Ser Asp Thr Gly Gln Tyr Val Cys Arg Ala Ile Asn Val
                3125                3130                3135    
Ala Gly Arg Asp Asp Lys Asn Phe His Leu Asn Val Tyr Val Pro Pro
            3140                3145                3150        
Ser Ile Glu Gly Pro Glu Arg Glu Val Ile Val Glu Thr Ile Ser Asn
        3155                3160                3165            
Pro Val Thr Leu Thr Cys Asp Ala Thr Gly Ile Pro Pro Pro Thr Ile
    3170                3175                3180                
Ala Trp Leu Lys Asn His Lys Arg Ile Glu Asn Ser Asp Ser Leu Glu
3185                3190                3195                3200
Val Arg Ile Leu Ser Gly Gly Ser Lys Leu Gln Ile Ala Arg Ser Gln
                3205                3210                3215    
His Ser Asp Ser Gly Asn Tyr Thr Cys Ile Ala Ser Asn Met Glu Gly
            3220                3225                3230        
Lys Ala Gln Lys Tyr Tyr Phe Leu Ser Ile Gln Val Pro Pro Ser Val
        3235                3240                3245            
Ala Gly Ala Glu Ile Pro Ser Asp Val Ser Val Leu Leu Gly Glu Asn
    3250                3255                3260                
Val Glu Leu Val Cys Asn Ala Asn Gly Ile Pro Thr Pro Leu Ile Gln
3265                3270                3275                3280
Trp Leu Lys Asp Gly Lys Pro Ile Ala Ser Gly Glu Thr Glu Arg Ile
                3285                3290                3295    
Arg Val Ser Ala Asn Gly Ser Thr Leu Asn Ile Tyr Gly Ala Leu Thr
            3300                3305                3310        
Ser Asp Thr Gly Lys Tyr Thr Cys Val Ala Thr Asn Pro Ala Gly Glu
        3315                3320                3325            
Glu Asp Arg Ile Phe Asn Leu Asn Val Tyr Val Thr Pro Thr Ile Arg
    3330                3335                3340                
Gly Asn Lys Asp Glu Ala Glu Lys Leu Met Thr Leu Val Asp Thr Ser
3345                3350                3355                3360
Ile Asn Ile Glu Cys Arg Ala Thr Gly Thr Pro Pro Pro Gln Ile Asn
                3365                3370                3375    
Trp Leu Lys Asn Gly Leu Pro Leu Pro Leu Ser Ser His Ile Arg Leu
            3380                3385                3390        
Leu Ala Ala Gly Gln Val Ile Arg Ile Val Arg Ala Gln Val Ser Asp
        3395                3400                3405            
Val Ala Val Tyr Thr Cys Val Ala Ser Asn Arg Ala Gly Val Asp Asn
    3410                3415                3420                
Lys His Tyr Asn Leu Gln Val Phe Ala Pro Pro Asn Met Asp Asn Ser
3425                3430                3435                3440
Met Gly Thr Glu Glu Ile Thr Val Leu Lys Gly Ser Ser Thr Ser Met
                3445                3450                3455    
Ala Cys Ile Thr Asp Gly Thr Pro Ala Pro Ser Met Ala Trp Leu Arg
            3460                3465                3470        
Asp Gly Gln Pro Leu Gly Leu Asp Ala His Leu Thr Val Ser Thr His
        3475                3480                3485            
Gly Met Val Leu Gln Leu Leu Lys Ala Glu Thr Glu Asp Ser Gly Lys
    3490                3495                3500                
Tyr Thr Cys Ile Ala Ser Asn Glu Ala Gly Glu Val Ser Lys His Phe
3505                3510                3515                3520
Ile Leu Lys Val Leu Glu Pro Pro His Ile Asn Gly Ser Glu Glu His
                3525                3530                3535    
Glu Glu Ile Ser Val Ile Val Asn Asn Pro Leu Glu Leu Thr Cys Ile
            3540                3545                3550        
Ala Ser Gly Ile Pro Ala Pro Lys Met Thr Trp Met Lys Asp Gly Arg
        3555                3560                3565            
Pro Leu Pro Gln Thr Asp Gln Val Gln Thr Leu Gly Gly Gly Glu Val
    3570                3575                3580                
Leu Arg Ile Ser Thr Ala Gln Val Glu Asp Thr Gly Arg Tyr Thr Cys
3585                3590                3595                3600
Leu Ala Ser Ser Pro Ala Gly Asp Asp Asp Lys Glu Tyr Leu Val Arg
                3605                3610                3615    
Val His Val Pro Pro Asn Ile Ala Gly Thr Asp Glu Pro Arg Asp Ile
            3620                3625                3630        
Thr Val Leu Arg Asn Arg Gln Val Thr Leu Glu Cys Lys Ser Asp Ala
        3635                3640                3645            
Val Pro Pro Pro Val Ile Thr Trp Leu Arg Asn Gly Glu Arg Leu Gln
    3650                3655                3660                
Ala Thr Pro Arg Val Arg Ile Leu Ser Gly Gly Arg Tyr Leu Gln Ile
3665                3670                3675                3680
Asn Asn Ala Asp Leu Gly Asp Thr Ala Asn Tyr Thr Cys Val Ala Ser
                3685                3690                3695    
Asn Ile Ala Gly Lys Thr Thr Arg Glu Phe Ile Leu Thr Val Asn Val
            3700                3705                3710        
Pro Pro Asn Ile Lys Gly Gly Pro Gln Ser Leu Val Ile Leu Leu Asn
        3715                3720                3725            
Lys Ser Thr Val Leu Glu Cys Ile Ala Glu Gly Val Pro Thr Pro Arg
    3730                3735                3740                
Ile Thr Trp Arg Lys Asp Gly Ala Val Leu Ala Gly Asn His Ala Arg
3745                3750                3755                3760
Tyr Ser Ile Leu Glu Asn Gly Phe Leu His Ile Gln Ser Ala His Val
                3765                3770                3775    
Thr Asp Thr Gly Arg Tyr Leu Cys Met Ala Thr Asn Ala Ala Gly Thr
            3780                3785                3790        
Asp Arg Arg Arg Ile Asp Leu Gln Val His Val Pro Pro Ser Ile Ala
        3795                3800                3805            
Pro Gly Pro Thr Asn Met Thr Val Ile Val Asn Val Gln Thr Thr Leu
    3810                3815                3820                
Ala Cys Glu Ala Thr Gly Ile Pro Lys Pro Ser Ile Asn Trp Arg Lys
3825                3830                3835                3840
Asn Gly His Leu Leu Asn Val Asp Gln Asn Gln Asn Ser Tyr Arg Leu
                3845                3850                3855    
Leu Ser Ser Gly Ser Leu Val Ile Ile Ser Pro Ser Val Asp Asp Thr
            3860                3865                3870        
Ala Thr Tyr Glu Cys Thr Val Thr Asn Gly Ala Gly Asp Asp Lys Arg
        3875                3880                3885            
Thr Val Asp Leu Thr Val Gln Val Pro Pro Ser Ile Ala Asp Glu Pro
    3890                3895                3900                
Thr Asp Phe Leu Val Thr Lys His Ala Pro Ala Val Ile Thr Cys Thr
3905                3910                3915                3920
Ala Ser Gly Val Pro Phe Pro Ser Ile His Trp Thr Lys Asn Gly Ile
                3925                3930                3935    
Arg Leu Leu Pro Arg Gly Asp Gly Tyr Arg Ile Leu Ser Ser Gly Ala
            3940                3945                3950        
Ile Glu Ile Leu Ala Thr Gln Leu Asn His Ala Gly Arg Tyr Thr Cys
        3955                3960                3965            
Val Ala Arg Asn Ala Ala Gly Ser Ala His Arg His Val Thr Leu His
    3970                3975                3980                
Val His Glu Pro Pro Val Ile Gln Pro Gln Pro Ser Glu Leu His Val
3985                3990                3995                4000
Ile Leu Asn Asn Pro Ile Leu Leu Pro Cys Glu Ala Thr Gly Thr Pro
                4005                4010                4015    
Ser Pro Phe Ile Thr Trp Gln Lys Glu Gly Ile Asn Val Asn Thr Ser
            4020                4025                4030        
Gly Arg Asn His Ala Val Leu Pro Ser Gly Gly Leu Gln Ile Ser Arg
        4035                4040                4045            
Ala Val Arg Glu Asp Ala Gly Thr Tyr Met Cys Val Ala Gln Asn Pro
    4050                4055                4060                
Ala Gly Thr Ala Leu Gly Lys Ile Lys Leu Asn Val Gln Val Pro Pro
4065                4070                4075                4080
Val Ile Ser Pro His Leu Lys Glu Tyr Val Ile Ala Val Asp Lys Pro
                4085                4090                4095    
Ile Thr Leu Ser Cys Glu Ala Asp Gly Leu Pro Pro Pro Asp Ile Thr
            4100                4105                4110        
Trp His Lys Asp Gly Arg Ala Ile Val Glu Ser Ile Arg Gln Arg Val
        4115                4120                4125            
Leu Ser Ser Gly Ser Leu Gln Ile Ala Phe Val Gln Pro Gly Asp Ala
    4130                4135                4140                
Gly His Tyr Thr Cys Met Ala Ala Asn Val Ala Gly Ser Ser Ser Thr
4145                4150                4155                4160
Ser Thr Lys Leu Thr Val His Val Pro Pro Arg Ile Arg Ser Thr Glu
                4165                4170                4175    
Gly His Tyr Thr Val Asn Glu Asn Ser Gln Ala Ile Leu Pro Cys Val
            4180                4185                4190        
Ala Asp Gly Ile Pro Thr Pro Ala Ile Asn Trp Lys Lys Asp Asn Val
        4195                4200                4205            
Leu Leu Ala Asn Leu Leu Gly Lys Tyr Thr Ala Glu Pro Tyr Gly Glu
    4210                4215                4220                
Leu Ile Leu Glu Asn Val Val Leu Glu Asp Ser Gly Phe Tyr Thr Cys
4225                4230                4235                4240
Val Ala Asn Asn Ala Ala Gly Glu Asp Thr His Thr Val Ser Leu Thr
                4245                4250                4255    
Val His Val Leu Pro Thr Phe Thr Glu Leu Pro Gly Asp Val Ser Leu
            4260                4265                4270        
Asn Lys Gly Glu Gln Leu Arg Leu Ser Cys Lys Ala Thr Gly Ile Pro
        4275                4280                4285            
Leu Pro Lys Leu Thr Trp Thr Phe Asn Asn Asn Ile Ile Pro Ala His
    4290                4295                4300                
Phe Asp Ser Val Asn Gly His Ser Glu Leu Val Ile Glu Arg Val Ser
4305                4310                4315                4320
Lys Glu Asp Ser Gly Thr Tyr Val Cys Thr Ala Glu Asn Ser Val Gly
                4325                4330                4335    
Phe Val Lys Ala Ile Gly Phe Val Tyr Val Lys Glu Pro Pro Val Phe
            4340                4345                4350        
Lys Gly Asp Tyr Pro Ser Asn Trp Ile Glu Pro Leu Gly Gly Asn Ala
        4355                4360                4365            
Ile Leu Asn Cys Glu Val Lys Gly Asp Pro Thr Pro Thr Ile Gln Trp
    4370                4375                4380                
Asn Arg Lys Gly Val Asp Ile Glu Ile Ser His Arg Ile Arg Gln Leu
4385                4390                4395                4400
Gly Asn Gly Ser Leu Ala Ile Tyr Gly Thr Val Asn Glu Asp Ala Gly
                4405                4410                4415    
Asp Tyr Thr Cys Val Ala Thr Asn Glu Ala Gly Val Val Glu Arg Ser
            4420                4425                4430        
Met Ser Leu Thr Leu Gln Ser Pro Pro Ile Ile Thr Leu Glu Pro Val
        4435                4440                4445            
Glu Thr Val Ile Asn Ala Gly Gly Lys Ile Ile Leu Asn Cys Gln Ala
    4450                4455                4460                
Thr Gly Glu Pro Gln Pro Thr Ile Thr Trp Ser Arg Gln Gly His Ser
4465                4470                4475                4480
Ile Ser Trp Asp Asp Arg Val Asn Val Leu Ser Asn Asn Ser Leu Tyr
                4485                4490                4495    
Ile Ala Asp Ala Gln Lys Glu Asp Thr Ser Glu Phe Glu Cys Val Ala
            4500                4505                4510        
Arg Asn Leu Met Gly Ser Val Leu Val Arg Val Pro Val Ile Val Gln
        4515                4520                4525            
Val His Gly Gly Phe Ser Gln Trp Ser Ala Trp Arg Ala Cys Ser Val
    4530                4535                4540                
Thr Cys Gly Lys Gly Ile Gln Lys Arg Ser Arg Leu Cys Asn Gln Pro
4545                4550                4555                4560
Leu Pro Ala Asn Gly Gly Lys Pro Cys Gln Gly Ser Asp Leu Glu Met
                4565                4570                4575    
Arg Asn Cys Gln Asn Lys Pro Cys Pro Val Asp Gly Ser Trp Ser Glu
            4580                4585                4590        
Trp Ser Leu Trp Glu Glu Cys Thr Arg Ser Cys Gly Arg Gly Asn Gln
        4595                4600                4605            
Thr Arg Thr Arg Thr Cys Asn Asn Pro Ser Val Gln His Gly Gly Arg
    4610                4615                4620                
Pro Cys Glu Gly Asn Ala Val Glu Ile Ile Met Cys Asn Ile Arg Pro
4625                4630                4635                4640
Cys Pro Val His Gly Ala Trp Ser Ala Trp Gln Pro Trp Gly Thr Cys
                4645                4650                4655    
Ser Glu Ser Cys Gly Lys Gly Thr Gln Thr Arg Ala Arg Leu Cys Asn
            4660                4665                4670        
Asn Pro Pro Pro Ala Phe Gly Gly Ser Tyr Cys Asp Gly Ala Glu Thr
        4675                4680                4685            
Gln Met Gln Val Cys Asn Glu Arg Asn Cys Pro Ile His Gly Lys Trp
    4690                4695                4700                
Ala Thr Trp Ala Ser Trp Ser Ala Cys Ser Val Ser Cys Gly Gly Gly
4705                4710                4715                4720
Ala Arg Gln Arg Thr Arg Gly Cys Ser Asp Pro Val Pro Gln Tyr Gly
                4725                4730                4735    
Gly Arg Lys Cys Glu Gly Ser Asp Val Gln Ser Asp Phe Cys Asn Ser
            4740                4745                4750        
Asp Pro Cys Pro Thr His Gly Asn Trp Ser Pro Trp Ser Gly Trp Gly
        4755                4760                4765            
Thr Cys Ser Arg Thr Cys Asn Gly Gly Gln Met Arg Arg Tyr Arg Thr
    4770                4775                4780                
Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly Arg Ala Cys Gly Gly Pro
4785                4790                4795                4800
Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp Met Cys Pro Val Asp Gly
                4805                4810                4815    
Ser Trp Gly Ser Trp His Ser Trp Ser Gln Cys Ser Ala Ser Cys Gly
            4820                4825                4830        
Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys Asp His Pro Val Pro Val
        4835                4840                4845            
Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr Thr Gln Val Thr Arg Cys
    4850                4855                4860                
Asn Val Gln Ala Cys Pro Gly Gly Pro Gln Arg Ala Arg Gly Ser Val
4865                4870                4875                4880
Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile Ala Phe Leu Asn Ala
                4885                4890                4895    
Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr Arg Ile Ile Arg Ala Lys
            4900                4905                4910        
Ile Thr Asn Val Pro Arg Ser Leu Gly Ser Ala Met Arg Lys Ile Val
        4915                4920                4925            
Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr Ala Lys Glu Ile Gly Glu
    4930                4935                4940                
Ala Val Asn Gly Phe Thr Leu Thr Asn Ala Val Phe Lys Arg Glu Thr
4945                4950                4955                4960
Gln Val Glu Phe Ala Thr Gly Glu Ile Leu Gln Met Ser His Ile Ala
                4965                4970                4975    
Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu Leu Asp Ile Val Val Ser
            4980                4985                4990        
Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala Glu Val Thr Val Lys Asp
        4995                5000                5005            
Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro Gly Gln Leu Tyr Ala Tyr
    5010                5015                5020                
Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile Ser Ile Pro Tyr Thr Trp
5025                5030                5035                5040
Asn His Thr Val Phe Tyr Asp Gln Ala Gln Gly Arg Met Pro Phe Leu
                5045                5050                5055    
Val Glu Thr Leu His Ala Ser Ser Val Glu Ser Asp Tyr Asn Gln Ile
            5060                5065                5070        
Glu Glu Thr Leu Gly Phe Lys Ile His Ala Ser Ile Ser Lys Gly Asp
        5075                5080                5085            
Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr Leu Asp Ser Val Gly Pro
    5090                5095                5100                
Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala Gly Asn Pro Cys Ser His
5105                5110                5115                5120
Ser Cys His Asn Ala Met Gly Thr Tyr Tyr Cys Ser Cys Pro Lys Gly
                5125                5130                5135    
Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys Gln Asp Ile Asp Glu Cys
            5140                5145                5150        
Ala Leu Gly Arg His Thr Cys His Ala Gly Gln Asp Cys Asp Asn Thr
        5155                5160                5165            
Ile Gly Ser Tyr Arg Cys Val Val Arg Cys Gly Ser Gly Phe Arg Arg
    5170                5175                5180                
Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile Asn Glu Cys Gln Glu Ser
5185                5190                5195                5200
Ser Pro Cys His Gln Arg Cys Phe Asn Ala Ile Gly Ser Phe His Cys
                5205                5210                5215    
Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly Arg Lys Cys Met Asp Val
            5220                5225                5230        
Asn Glu Cys Arg Gln Asn Val Cys Arg Pro Asp Gln His Cys Lys Asn
        5235                5240                5245            
Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu Cys Pro Asn Gly Met Thr
    5250                5255                5260                
Lys Ala Glu Asn Gly Thr Cys Ile Asp Ile Asp Glu Cys Lys Asp Gly
5265                5270                5275                5280
Thr His Gln Cys Arg Tyr Asn Gln Ile Cys Glu Asn Thr Arg Gly Ser
                5285                5290                5295    
Tyr Arg Cys Val Cys Pro Arg Gly Tyr Arg Ser Gln Gly Val Gly Arg
            5300                5305                5310        
Pro Cys Met Asp Ile Asn Glu Cys Glu Gln Val Pro Lys Pro Cys Ala
        5315                5320                5325            
His Gln Cys Ser Asn Thr Pro Gly Ser Phe Lys Cys Ile Cys Pro Pro
    5330                5335                5340                
Gly Gln His Leu Leu Gly Asp Gly Lys Ser Cys Ala Gly Leu Glu Arg
5345                5350                5355                5360
Leu Pro Asn Tyr Gly Thr Gln Tyr Ser Ser Tyr Asn Leu Ala Arg Phe
                5365                5370                5375    
Ser Pro Val Arg Asn Asn Tyr Gln Pro Gln Gln His Tyr Arg Gln Tyr
            5380                5385                5390        
Ser His Leu Tyr Ser Ser Tyr Ser Glu Tyr Arg Asn Ser Arg Thr Ser
        5395                5400                5405            
Leu Ser Arg Thr Arg Arg Thr Ile Arg Lys Thr Cys Pro Glu Gly Ser
    5410                5415                5420                
Glu Ala Ser His Asp Thr Cys Val Asp Ile Asp Glu Cys Glu Asn Thr
5425                5430                5435                5440
Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe Gly Ser Tyr Gln Cys
                5445                5450                5455    
Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn Gly Lys Thr Cys Gln
            5460                5465                5470        
Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His Cys Gly Pro Asn Arg
        5475                5480                5485            
Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys Ile Asp Thr Pro Cys
    5490                5495                5500                
Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly Phe Cys Leu Lys Asn
5505                5510                5515                5520
Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser Pro Tyr Ala Leu Glu
                5525                5530                5535    
Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala Thr Asn Gln Asp Leu
            5540                5545                5550        
Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val Met His Pro Arg Thr
        5555                5560                5565            
Thr Phe Leu Met Val Asp Glu Glu Gln Thr Val Pro Phe Ala Leu Arg
    5570                5575                5580                
Asp Glu Asn Leu Lys Gly Val Val Tyr Thr Thr Arg Pro Leu Arg Glu
5585                5590                5595                5600
Ala Glu Thr Tyr Arg Met Arg Val Arg Ala Ser Ser Tyr Ser Ala Asn
                5605                5610                5615    
Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile Val Tyr Ile Ala Val Ser
            5620                5625                5630        
Ala Tyr Pro Tyr
        5635    


<210> 6361
<211> 5636
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 3003, 3041, 3367
<223> Xaa = Any Amino Acid

<400> 6361
Met Ile Ser Trp Glu Val Val His Thr Val Phe Leu Phe Ala Leu Leu
 1               5                  10                  15      
Tyr Ser Ser Leu Ala Gln Asp Ala Ser Pro Gln Ser Glu Ile Arg Ala
            20                  25                  30          
Glu Glu Phe Pro Glu Gly Ala Ser Thr Leu Ala Phe Val Phe Asp Val
        35                  40                  45              
Thr Gly Ser Met Tyr Asp Asp Leu Val Gln Val Ile Glu Gly Ala Ser
    50                  55                  60                  
Lys Ile Leu Glu Thr Ser Leu Lys Arg Pro Lys Arg Pro Leu Phe Asn
65                  70                  75                  80  
Phe Ala Leu Val Pro Phe His Asp Pro Glu Ile Gly Pro Val Thr Ile
                85                  90                  95      
Thr Thr Asp Pro Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val
            100                 105                 110         
Gln Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys Ile
        115                 120                 125             
Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr Asp
    130                 135                 140                 
Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu Ile
145                 150                 155                 160 
Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Asp
                165                 170                 175     
Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser Thr
            180                 185                 190         
Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu Val
        195                 200                 205             
Leu Lys Trp Val Glu Glu Ala Val Gln Ala Ser Lys Val His Leu Leu
    210                 215                 220                 
Ser Thr Asp His Leu Glu Gln Ala Val Asn Thr Trp Arg Ile Pro Phe
225                 230                 235                 240 
Asp Pro Ser Leu Lys Glu Val Thr Val Ser Leu Ser Gly Pro Ser Pro
                245                 250                 255     
Met Ile Glu Ile Arg Asn Pro Leu Gly Lys Leu Ile Lys Lys Gly Phe
            260                 265                 270         
Gly Leu His Glu Leu Leu Asn Ile His Asn Ser Ala Lys Val Val Asn
        275                 280                 285             
Val Lys Glu Pro Glu Ala Gly Met Trp Thr Val Lys Thr Ser Ser Ser
    290                 295                 300                 
Gly Arg His Ser Val Arg Ile Thr Gly Leu Ser Thr Ile Asp Phe Arg
305                 310                 315                 320 
Ala Gly Phe Ser Arg Lys Pro Thr Leu Asp Phe Lys Lys Thr Val Ser
                325                 330                 335     
Arg Pro Val Gln Gly Ile Pro Thr Tyr Val Leu Leu Asn Thr Ser Gly
            340                 345                 350         
Ile Ser Thr Pro Ala Arg Ile Asp Leu Leu Glu Leu Leu Ser Ile Ser
        355                 360                 365             
Gly Ser Ser Leu Lys Thr Ile Pro Val Lys Tyr Tyr Pro His Arg Lys
    370                 375                 380                 
Pro Tyr Gly Ile Trp Asn Ile Ser Asp Phe Val Pro Pro Asn Glu Ala
385                 390                 395                 400 
Phe Phe Leu Lys Val Thr Gly Tyr Asp Lys Asp Asp Tyr Leu Phe Gln
                405                 410                 415     
Arg Val Ser Ser Val Ser Phe Ser Ser Ile Val Pro Asp Ala Pro Lys
            420                 425                 430         
Val Thr Met Pro Glu Lys Thr Pro Gly Tyr Tyr Leu Gln Pro Gly Gln
        435                 440                 445             
Ile Pro Cys Ser Val Asp Ser Leu Leu Pro Phe Thr Leu Ser Phe Val
    450                 455                 460                 
Arg Asn Gly Val Thr Leu Gly Val Asp Gln Tyr Leu Lys Glu Ser Ala
465                 470                 475                 480 
Ser Val Ser Leu Asp Ile Ala Lys Val Thr Leu Ser Asp Glu Gly Phe
                485                 490                 495     
Tyr Glu Cys Ile Ala Val Ser Ser Ala Gly Thr Gly Arg Ala Gln Thr
            500                 505                 510         
Phe Phe Asp Val Ser Glu Pro Pro Pro Val Ile Gln Val Pro Asn Asn
        515                 520                 525             
Val Thr Val Thr Pro Gly Glu Arg Ala Val Leu Thr Cys Leu Ile Ile
    530                 535                 540                 
Ser Ala Val Asp Tyr Asn Leu Thr Trp Gln Arg Asn Asp Arg Asp Val
545                 550                 555                 560 
Arg Leu Ala Glu Pro Ala Arg Ile Arg Thr Leu Ala Asn Leu Ser Leu
                565                 570                 575     
Glu Leu Lys Ser Val Lys Phe Asn Asp Ala Gly Glu Tyr His Cys Met
            580                 585                 590         
Val Ser Ser Glu Gly Gly Ser Ser Ala Ala Ser Val Phe Leu Thr Val
        595                 600                 605             
Gln Glu Pro Pro Lys Val Thr Val Met Pro Lys Asn Gln Ser Phe Thr
    610                 615                 620                 
Gly Gly Ser Glu Val Ser Ile Met Cys Ser Ala Thr Gly Tyr Pro Lys
625                 630                 635                 640 
Pro Lys Ile Ala Trp Thr Val Asn Asp Met Phe Ile Val Gly Ser His
                645                 650                 655     
Arg Tyr Arg Met Thr Ser Asp Gly Thr Leu Phe Ile Lys Asn Ala Ala
            660                 665                 670         
Pro Lys Asp Ala Gly Ile Tyr Gly Cys Leu Ala Ser Asn Ser Ala Gly
        675                 680                 685             
Thr Asp Lys Gln Asn Ser Thr Leu Arg Tyr Ile Glu Ala Pro Lys Leu
    690                 695                 700                 
Met Val Val Gln Ser Glu Leu Leu Val Ala Leu Gly Asp Ile Thr Val
705                 710                 715                 720 
Met Glu Cys Lys Thr Ser Gly Ile Pro Pro Pro Gln Val Lys Trp Phe
                725                 730                 735     
Lys Gly Asp Leu Glu Leu Arg Pro Ser Thr Phe Leu Ile Ile Asp Pro
            740                 745                 750         
Leu Leu Gly Leu Leu Lys Ile Gln Glu Thr Gln Asp Leu Asp Ala Gly
        755                 760                 765             
Asp Tyr Thr Cys Val Ala Ile Asn Glu Ala Gly Arg Ala Thr Gly Lys
    770                 775                 780                 
Ile Thr Leu Asp Val Gly Ser Pro Pro Val Phe Ile Gln Glu Pro Ala
785                 790                 795                 800 
Asp Val Ser Met Glu Ile Gly Ser Asn Val Thr Leu Pro Cys Tyr Val
                805                 810                 815     
Gln Gly Tyr Pro Glu Pro Thr Ile Lys Trp Arg Arg Leu Asp Asn Met
            820                 825                 830         
Pro Ile Phe Ser Arg Pro Phe Ser Val Ser Ser Ile Ser Gln Leu Arg
        835                 840                 845             
Thr Gly Ala Leu Phe Ile Leu Asn Leu Trp Ala Ser Asp Lys Gly Thr
    850                 855                 860                 
Tyr Ile Cys Glu Ala Glu Asn Gln Phe Gly Lys Ile Gln Ser Glu Thr
865                 870                 875                 880 
Thr Val Thr Val Thr Gly Leu Val Ala Pro Leu Ile Gly Ile Ser Pro
                885                 890                 895     
Ser Val Ala Asn Val Ile Glu Gly Gln Gln Leu Thr Leu Pro Cys Thr
            900                 905                 910         
Leu Leu Ala Gly Asn Pro Ile Pro Glu Arg Arg Trp Ile Lys Asn Ser
        915                 920                 925             
Ala Met Leu Leu Gln Asn Pro Tyr Ile Thr Val Arg Ser Asp Gly Ser
    930                 935                 940                 
Leu His Ile Glu Arg Val Gln Leu Gln Asp Gly Gly Glu Tyr Thr Cys
945                 950                 955                 960 
Val Ala Ser Asn Val Ala Gly Thr Asn Asn Lys Thr Thr Ser Val Val
                965                 970                 975     
Val His Val Leu Pro Thr Ile Gln His Gly Gln Gln Ile Leu Ser Thr
            980                 985                 990         
Ile Glu Gly Ile Pro Val Thr Leu Pro Cys Lys Ala Ser Gly Asn Pro
        995                 1000                1005            
Lys Pro Ser Val Ile Trp Ser Lys Lys Gly Glu Leu Ile Ser Thr Ser
    1010                1015                1020                
Ser Ala Lys Phe Ser Ala Gly Ala Asp Gly Ser Leu Tyr Val Val Ser
1025                1030                1035                1040
Pro Glu Gly Glu Glu Ser Gly Glu Tyr Val Cys Thr Ala Thr Asn Thr
                1045                1050                1055    
Ala Gly Tyr Ala Lys Arg Lys Val Gln Leu Thr Val Tyr Val Arg Pro
            1060                1065                1070        
Arg Val Phe Gly Asp Leu Arg Gly Leu Ser Gln Asp Lys Pro Val Glu
        1075                1080                1085            
Ile Ser Val Leu Ala Gly Glu Glu Val Thr Leu Pro Cys Glu Val Lys
    1090                1095                1100                
Ser Leu Pro Pro Pro Ile Ile Thr Trp Ala Lys Glu Thr Gln Leu Ile
1105                1110                1115                1120
Ser Pro Phe Ser Pro Arg His Thr Phe Leu Pro Ser Gly Ser Met Lys
                1125                1130                1135    
Ile Thr Glu Thr Arg Thr Ser Asp Ser Gly Met Tyr Leu Cys Val Ala
            1140                1145                1150        
Thr Asn Ile Ala Gly Asn Val Thr Gln Ala Val Lys Leu Asn Val His
        1155                1160                1165            
Val Pro Pro Lys Ile Gln Arg Gly Pro Lys His Leu Lys Val Gln Val
    1170                1175                1180                
Gly Gln Arg Val Asp Ile Pro Cys Asn Ala Gln Gly Thr Pro Leu Pro
1185                1190                1195                1200
Val Ile Thr Trp Ser Lys Gly Gly Ser Thr Met Leu Val Asp Gly Glu
                1205                1210                1215    
His His Val Ser Asn Pro Asp Gly Thr Leu Ser Ile Asp Gln Ala Thr
            1220                1225                1230        
Pro Ser Asp Ala Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Ala Gly
        1235                1240                1245            
Thr Asp Glu Thr Glu Ile Thr Leu His Val Gln Glu Pro Pro Thr Val
    1250                1255                1260                
Glu Asp Leu Glu Pro Pro Tyr Asn Thr Thr Phe Gln Glu Arg Val Ala
1265                1270                1275                1280
Asn Gln Arg Ile Glu Phe Pro Cys Pro Ala Lys Gly Thr Pro Lys Pro
                1285                1290                1295    
Thr Ile Lys Trp Leu His Asn Gly Arg Glu Leu Thr Gly Arg Glu Pro
            1300                1305                1310        
Gly Ile Ser Ile Leu Glu Glu Gly Thr Leu Leu Val Ile Ala Ser Val
        1315                1320                1325            
Thr Pro Tyr Asp Asn Gly Glu Tyr Ile Cys Val Ala Val Asn Glu Ala
    1330                1335                1340                
Gly Thr Thr Glu Arg Lys Tyr Asn Leu Lys Val His Val Pro Pro Val
1345                1350                1355                1360
Ile Lys Asp Lys Glu Gln Val Ser Asn Val Ser Val Leu Leu Asn Gln
                1365                1370                1375    
Leu Thr Asn Leu Phe Cys Glu Val Glu Gly Thr Pro Ser Pro Ile Ile
            1380                1385                1390        
Met Trp Tyr Lys Asp Asn Val Gln Val Thr Glu Ser Ser Thr Ile Gln
        1395                1400                1405            
Thr Val Asn Asn Gly Lys Ile Leu Lys Leu Phe Arg Ala Thr Pro Glu
    1410                1415                1420                
Asp Ala Gly Arg Tyr Ser Cys Lys Ala Ile Asn Ile Ala Gly Thr Ser
1425                1430                1435                1440
Gln Lys Tyr Phe Asn Ile Asp Val Leu Val Pro Pro Thr Ile Ile Gly
                1445                1450                1455    
Thr Asn Phe Pro Lys Glu Val Ser Val Val Leu Asn Arg Asp Val Ala
            1460                1465                1470        
Leu Glu Cys Gln Val Lys Gly Thr Pro Phe Pro Asp Ile His Trp Phe
        1475                1480                1485            
Lys Asp Gly Lys Pro Leu Phe Leu Gly Asp Pro Asn Val Glu Leu Leu
    1490                1495                1500                
Asp Arg Gly Gln Val Leu His Leu Lys Asn Ala Arg Arg Asn Asp Lys
1505                1510                1515                1520
Gly Arg Tyr Gln Cys Thr Val Ser Asn Ala Ala Gly Lys Gln Ala Lys
                1525                1530                1535    
Asp Ile Lys Leu Thr Ile Tyr Ile Pro Pro Ser Ile Lys Gly Gly Asn
            1540                1545                1550        
Val Thr Thr Asp Ile Ser Val Leu Ile Asn Ser Leu Ile Lys Leu Glu
        1555                1560                1565            
Cys Lys Thr Arg Gly Leu Pro Met Pro Ala Ile Thr Trp Tyr Lys Asp
    1570                1575                1580                
Gly Gln Pro Ile Met Ser Ser Ser Gln Ala Leu Tyr Ile Asp Lys Gly
1585                1590                1595                1600
Gln Tyr Leu His Ile Pro Arg Ala Gln Val Ser Asp Ser Ala Thr Tyr
                1605                1610                1615    
Thr Cys His Val Ala Asn Val Ala Gly Thr Ala Glu Lys Ser Phe His
            1620                1625                1630        
Val Asp Val Tyr Val Pro Pro Met Ile Glu Gly Asn Leu Ala Thr Pro
        1635                1640                1645            
Leu Asn Lys Gln Val Val Ile Ala His Ser Leu Thr Leu Glu Cys Asn
    1650                1655                1660                
Ala Ala Gly Asn Pro Ser Pro Ile Leu Thr Trp Leu Lys Asp Gly Val
1665                1670                1675                1680
Pro Val Lys Ala Asn Asp Asn Phe Arg Ile Glu Ala Gly Gly Lys Lys
                1685                1690                1695    
Leu Glu Ile Met Ser Ala Gln Glu Ile Asp Arg Gly Gln Tyr Ile Cys
            1700                1705                1710        
Val Ala Thr Ser Val Ala Gly Glu Lys Glu Ile Lys Tyr Glu Val Asp
        1715                1720                1725            
Val Leu Val Pro Pro Ala Ile Glu Gly Gly Asp Glu Thr Ser Tyr Phe
    1730                1735                1740                
Ile Val Met Val Asn Asn Leu Leu Glu Leu Asp Cys His Val Thr Gly
1745                1750                1755                1760
Ser Pro Pro Pro Thr Ile Met Trp Leu Lys Asp Gly Gln Leu Ile Asp
                1765                1770                1775    
Glu Arg Asp Gly Phe Lys Ile Leu Leu Asn Gly Arg Lys Leu Val Ile
            1780                1785                1790        
Ala Gln Ala Gln Val Ser Asn Thr Gly Leu Tyr Arg Cys Met Ala Ala
        1795                1800                1805            
Asn Thr Ala Gly Asp His Lys Lys Glu Phe Glu Val Thr Val His Val
    1810                1815                1820                
Pro Pro Thr Ile Lys Ser Ser Gly Leu Ser Glu Arg Val Val Val Lys
1825                1830                1835                1840
Tyr Lys Pro Val Ala Leu Gln Cys Ile Ala Asn Gly Ile Pro Asn Pro
                1845                1850                1855    
Ser Ile Thr Trp Leu Lys Asp Asp Gln Pro Val Asn Thr Ala Gln Gly
            1860                1865                1870        
Asn Leu Lys Ile Gln Ser Ser Gly Arg Val Leu Gln Ile Ala Lys Thr
        1875                1880                1885            
Leu Leu Glu Asp Ala Gly Arg Tyr Thr Cys Val Ala Thr Asn Ala Ala
    1890                1895                1900                
Gly Glu Thr Gln Gln His Ile Gln Leu His Val His Glu Pro Pro Ser
1905                1910                1915                1920
Leu Glu Asp Ala Gly Lys Met Leu Asn Glu Thr Val Leu Val Ser Asn
                1925                1930                1935    
Pro Val Gln Leu Glu Cys Lys Ala Ala Gly Asn Pro Val Pro Val Ile
            1940                1945                1950        
Thr Trp Tyr Lys Asp Asn Cys Leu Leu Ser Gly Ser Thr Ser Met Thr
        1955                1960                1965            
Phe Leu Asn Arg Gly Gln Ile Ile Asp Ile Glu Ser Ala Gln Ile Ser
    1970                1975                1980                
Asp Ala Gly Ile Tyr Lys Cys Val Ala Ile Asn Ser Ala Gly Ala Thr
1985                1990                1995                2000
Glu Leu Phe Tyr Ser Leu Gln Val His Val Ala Pro Ser Ile Ser Gly
                2005                2010                2015    
Ser Asn Asn Met Val Ala Val Val Val Asn Asn Pro Val Arg Leu Glu
            2020                2025                2030        
Cys Glu Ala Arg Gly Ile Pro Ala Pro Ser Leu Thr Trp Leu Lys Asp
        2035                2040                2045            
Gly Ser Pro Val Ser Ser Phe Ser Asn Gly Leu Gln Val Leu Ser Gly
    2050                2055                2060                
Gly Arg Ile Leu Ala Leu Thr Ser Thr Gln Ile Ser Asp Thr Gly Arg
2065                2070                2075                2080
Tyr Thr Cys Val Ala Val Asn Ala Ala Gly Glu Lys Gln Arg Asp Ile
                2085                2090                2095    
Asp Leu Arg Val Tyr Val Pro Pro Asn Ile Met Gly Glu Glu Gln Asn
            2100                2105                2110        
Val Ser Val Leu Ile Ser Gln Ala Val Glu Leu Leu Cys Gln Ser Asp
        2115                2120                2125            
Ala Ile Pro Pro Pro Thr Leu Thr Trp Leu Lys Asp Gly His Pro Leu
    2130                2135                2140                
Leu Lys Lys Pro Gly Leu Ser Ile Ser Glu Asn Arg Ser Val Leu Lys
2145                2150                2155                2160
Ile Glu Asp Ala Gln Val Gln Asp Thr Gly Arg Tyr Thr Cys Glu Ala
                2165                2170                2175    
Thr Asn Val Ala Gly Lys Thr Glu Lys Lys Asn Tyr Asn Val Asn Ile
            2180                2185                2190        
Trp Val Pro Pro Asn Ile Gly Gly Ser Asp Glu Leu Thr Gln Leu Thr
        2195                2200                2205            
Val Ile Glu Gly Asn Leu Ile Ser Leu Leu Cys Glu Ser Ser Gly Ile
    2210                2215                2220                
Pro Pro Pro Asn Leu Ile Trp Lys Lys Lys Gly Ser Pro Val Leu Thr
2225                2230                2235                2240
Asp Ser Met Gly Arg Val Arg Ile Leu Ser Gly Gly Arg Gln Leu Gln
                2245                2250                2255    
Ile Ser Ile Ala Glu Lys Ser Asp Ala Ala Leu Tyr Ser Cys Val Ala
            2260                2265                2270        
Ser Asn Val Ala Gly Thr Ala Lys Lys Glu Tyr Asn Leu Gln Val Tyr
        2275                2280                2285            
Ile Arg Pro Thr Ile Thr Asn Ser Gly Ser His Pro Thr Glu Ile Ile
    2290                2295                2300                
Val Thr Arg Gly Lys Ser Ile Ser Leu Glu Cys Glu Val Gln Gly Ile
2305                2310                2315                2320
Pro Pro Pro Thr Val Thr Trp Met Lys Asp Gly His Pro Leu Ile Lys
                2325                2330                2335    
Ala Lys Gly Val Glu Ile Leu Asp Glu Gly His Ile Leu Gln Leu Lys
            2340                2345                2350        
Asn Ile His Val Ser Asp Thr Gly Arg Tyr Val Cys Val Ala Val Asn
        2355                2360                2365            
Val Ala Gly Met Thr Asp Lys Lys Tyr Asp Leu Ser Val His Ala Pro
    2370                2375                2380                
Pro Ser Ile Ile Gly Asn His Arg Ser Pro Glu Asn Ile Ser Val Val
2385                2390                2395                2400
Glu Lys Asn Ser Val Ser Leu Thr Cys Glu Ala Ser Gly Ile Pro Leu
                2405                2410                2415    
Pro Ser Thr Thr Trp Phe Lys Asp Gly Trp Pro Val Ser Leu Ser Asn
            2420                2425                2430        
Ser Val Arg Ile Leu Ser Gly Gly Arg Met Leu Arg Leu Met Gln Thr
        2435                2440                2445            
Thr Met Glu Asp Ala Gly Gln Tyr Thr Cys Val Val Arg Asn Ala Ala
    2450                2455                2460                
Gly Glu Glu Arg Lys Ile Phe Gly Leu Ser Val Leu Val Pro Pro His
2465                2470                2475                2480
Ile Val Gly Glu Asn Thr Leu Glu Asp Val Lys Val Lys Glu Lys Gln
                2485                2490                2495    
Ser Val Thr Leu Thr Cys Glu Val Thr Gly Asn Pro Val Pro Glu Ile
            2500                2505                2510        
Thr Trp His Lys Asp Gly Gln Pro Leu Gln Glu Asp Glu Ala His His
        2515                2520                2525            
Ile Ile Ser Gly Gly Arg Phe Leu Gln Ile Thr Asn Val Gln Val Pro
    2530                2535                2540                
His Thr Gly Arg Tyr Thr Cys Leu Ala Ser Ser Pro Ala Gly His Lys
2545                2550                2555                2560
Ser Arg Ser Phe Ser Leu Asn Val Phe Val Ser Pro Thr Ile Ala Gly
                2565                2570                2575    
Val Gly Ser Asp Gly Asn Pro Glu Asp Val Thr Val Ile Leu Asn Ser
            2580                2585                2590        
Pro Thr Ser Leu Val Cys Glu Ala Tyr Ser Tyr Pro Pro Ala Thr Ile
        2595                2600                2605            
Thr Trp Phe Lys Asp Gly Thr Pro Leu Glu Ser Asn Arg Asn Ile Arg
    2610                2615                2620                
Ile Leu Pro Gly Gly Arg Thr Leu Gln Ile Leu Asn Ala Gln Glu Asp
2625                2630                2635                2640
Asn Ala Gly Arg Tyr Ser Cys Val Ala Thr Asn Glu Ala Gly Glu Met
                2645                2650                2655    
Ile Lys His Tyr Glu Val Lys Val Tyr Ile Pro Pro Ile Ile Asn Lys
            2660                2665                2670        
Gly Asp Leu Trp Gly Pro Gly Leu Ser Pro Lys Glu Val Lys Ile Lys
        2675                2680                2685            
Val Asn Asn Thr Leu Thr Leu Glu Cys Glu Ala Tyr Ala Ile Pro Ser
    2690                2695                2700                
Ala Ser Leu Ser Trp Tyr Lys Asp Gly Gln Pro Leu Lys Ser Asp Asp
2705                2710                2715                2720
His Val Asn Ile Ala Ala Asn Gly His Thr Leu Gln Ile Lys Glu Ala
                2725                2730                2735    
Gln Ile Ser Asp Thr Gly Arg Tyr Thr Cys Val Ala Ser Asn Ile Ala
            2740                2745                2750        
Gly Glu Asp Glu Leu Asp Phe Asp Val Asn Ile Gln Val Pro Pro Ser
        2755                2760                2765            
Phe Gln Lys Leu Trp Glu Ile Gly Asn Met Leu Asp Thr Gly Arg Asn
    2770                2775                2780                
Gly Glu Ala Lys Asp Val Ile Ile Asn Asn Pro Ile Ser Leu Tyr Cys
2785                2790                2795                2800
Glu Thr Asn Ala Ala Pro Pro Pro Thr Leu Thr Trp Tyr Lys Asp Gly
                2805                2810                2815    
His Pro Leu Thr Ser Ser Asp Lys Val Leu Ile Leu Pro Gly Gly Arg
            2820                2825                2830        
Val Leu Gln Ile Pro Arg Ala Lys Val Glu Asp Ala Gly Arg Tyr Thr
        2835                2840                2845            
Cys Val Ala Val Asn Glu Ala Gly Glu Asp Ser Leu Gln Tyr Asp Val
    2850                2855                2860                
Arg Val Leu Val Pro Pro Ile Ile Glu Gly Ala Asn Ser Asp Leu Pro
2865                2870                2875                2880
Glu Glu Val Thr Val Leu Val Asn Lys Ser Ala Leu Ile Glu Cys Leu
                2885                2890                2895    
Ser Ser Gly Ser Pro Ala Pro Arg Asn Ser Trp Gln Lys Asp Gly Gln
            2900                2905                2910        
Pro Leu Leu Glu Asp Asp His His Lys Phe Leu Ser Asn Gly Arg Ile
        2915                2920                2925            
Leu Gln Ile Leu Asn Thr Gln Ile Thr Asp Ile Gly Arg Tyr Val Cys
    2930                2935                2940                
Val Ala Glu Asn Thr Ala Gly Ser Ala Lys Lys Tyr Phe Asn Leu Asn
2945                2950                2955                2960
Val His Val Pro Pro Ser Val Ile Gly Pro Lys Ser Glu Asn Leu Thr
                2965                2970                2975    
Val Val Val Asn Asn Phe Ile Ser Leu Thr Cys Glu Val Ser Gly Phe
            2980                2985                2990        
Pro Pro Pro Asp Leu Ser Trp Leu Lys Asn Xaa Gln Pro Ile Lys Leu
        2995                3000                3005            
Asn Thr Asn Thr Leu Ile Val Pro Gly Gly Arg Thr Leu Gln Ile Ile
    3010                3015                3020                
Arg Ala Lys Val Ser Asp Gly Gly Glu Tyr Thr Cys Ile Ala Ile Asn
3025                3030                3035                3040
Xaa Ala Gly Glu Ser Lys Lys Lys Phe Ser Leu Thr Val Tyr Val Pro
                3045                3050                3055    
Pro Ser Ile Lys Asp His Asp Ser Glu Ser Leu Ser Val Val Asn Val
            3060                3065                3070        
Arg Glu Gly Thr Ser Val Ser Leu Glu Cys Glu Ser Asn Ala Val Pro
        3075                3080                3085            
Pro Pro Val Ile Thr Trp Tyr Lys Asn Gly Arg Met Ile Thr Glu Ser
    3090                3095                3100                
Thr His Val Glu Ile Leu Ala Asp Gly Gln Met Leu His Ile Lys Lys
3105                3110                3115                3120
Ala Glu Val Ser Asp Thr Gly Gln Tyr Val Cys Arg Ala Ile Asn Val
                3125                3130                3135    
Ala Gly Arg Asp Asp Lys Asn Phe His Leu Asn Val Tyr Val Pro Pro
            3140                3145                3150        
Ser Ile Glu Gly Pro Glu Arg Glu Val Ile Val Glu Thr Ile Ser Asn
        3155                3160                3165            
Pro Val Thr Leu Thr Cys Asp Ala Thr Gly Ile Pro Pro Pro Thr Ile
    3170                3175                3180                
Ala Trp Leu Lys Asn Tyr Lys Arg Ile Glu Asn Ser Asp Ser Leu Glu
3185                3190                3195                3200
Val Arg Ile Leu Ser Gly Gly Ser Lys Leu Gln Ile Ala Arg Ser Gln
                3205                3210                3215    
His Ser Asp Ser Gly Asn Tyr Thr Cys Ile Ala Ser Asn Met Glu Gly
            3220                3225                3230        
Lys Ala Gln Lys Tyr Tyr Phe Leu Ser Ile Gln Val Pro Pro Ser Val
        3235                3240                3245            
Ala Gly Ala Glu Ile Pro Ser Asp Val Ser Val Leu Leu Gly Glu Asn
    3250                3255                3260                
Val Glu Leu Val Cys Asn Ala Asn Gly Ile Pro Thr Pro Leu Ile Gln
3265                3270                3275                3280
Trp Leu Lys Asp Gly Lys Pro Ile Ala Ser Gly Glu Thr Glu Arg Ile
                3285                3290                3295    
Arg Val Ser Ala Asn Gly Ser Thr Leu Asn Ile Tyr Gly Ala Leu Thr
            3300                3305                3310        
Ser Asp Thr Gly Lys Tyr Thr Cys Val Ala Thr Asn Pro Ala Gly Glu
        3315                3320                3325            
Glu Asp Arg Ile Phe Asn Leu Asn Val Tyr Val Thr Pro Thr Ile Arg
    3330                3335                3340                
Gly Asn Lys Asp Glu Ala Glu Lys Leu Met Thr Tyr Val Asp Thr Ser
3345                3350                3355                3360
Ile Asn Ile Glu Cys Arg Xaa Thr Gly Thr Pro Pro Pro Gln Ile Asn
                3365                3370                3375    
Trp Leu Lys Asn Gly Leu Pro Leu Pro Leu Ser Ser His Ile Arg Leu
            3380                3385                3390        
Leu Ala Ala Gly Gln Val Ile Arg Ile Val Arg Ala Gln Val Ser Asp
        3395                3400                3405            
Val Ala Val Tyr Thr Cys Val Ala Ser Asn Arg Ala Gly Val Asp Asn
    3410                3415                3420                
Lys His Tyr Asn Leu Gln Val Phe Ala Pro Pro Asn Met Asp Asn Ser
3425                3430                3435                3440
Met Gly Thr Glu Glu Ile Thr Val Leu Lys Gly Ser Ser Thr Ser Met
                3445                3450                3455    
Ala Cys Ile Thr Asp Gly Thr Pro Ala Pro Ser Met Ala Trp Leu Arg
            3460                3465                3470        
Asp Gly Gln Pro Leu Gly Leu Asp Ala His Leu Thr Val Ser Thr His
        3475                3480                3485            
Gly Met Val Leu Gln Leu Leu Lys Ala Glu Thr Glu Asp Ser Gly Lys
    3490                3495                3500                
Tyr Thr Cys Ile Ala Ser Asn Glu Ala Gly Glu Val Ser Lys His Phe
3505                3510                3515                3520
Ile Leu Lys Val Leu Glu Pro Pro His Ile Asn Gly Ser Glu Glu His
                3525                3530                3535    
Glu Glu Ile Ser Val Ile Val Asn Asn Pro Leu Glu Leu Thr Cys Ile
            3540                3545                3550        
Ala Ser Gly Ile Pro Ala Pro Lys Met Thr Trp Met Lys Asp Gly Arg
        3555                3560                3565            
Pro Leu Pro Gln Thr Asp Gln Val Gln Thr Leu Gly Gly Gly Glu Val
    3570                3575                3580                
Leu Arg Ile Ser Thr Ala Gln Val Glu Asp Thr Gly Arg Tyr Thr Cys
3585                3590                3595                3600
Leu Ala Ser Ser Pro Ala Gly Asp Asp Asp Lys Glu Tyr Leu Val Arg
                3605                3610                3615    
Val His Val Pro Pro Asn Ile Ala Gly Thr Asp Glu Pro Arg Asp Ile
            3620                3625                3630        
Thr Val Leu Arg Asn Arg Gln Val Thr Leu Glu Cys Lys Ser Asp Ala
        3635                3640                3645            
Val Pro Pro Pro Val Ile Thr Trp Leu Arg Asn Gly Glu Arg Leu Gln
    3650                3655                3660                
Ala Thr Pro Arg Val Arg Ile Leu Ser Gly Gly Arg Tyr Leu Gln Ile
3665                3670                3675                3680
Asn Asn Ala Asp Leu Gly Asp Thr Ala Asn Tyr Thr Cys Val Ala Ser
                3685                3690                3695    
Asn Ile Ala Gly Lys Thr Thr Arg Glu Phe Ile Leu Thr Val Asn Val
            3700                3705                3710        
Pro Pro Asn Ile Lys Gly Gly Pro Gln Ser Leu Val Ile Leu Leu Asn
        3715                3720                3725            
Lys Ser Thr Val Leu Glu Cys Ile Ala Glu Gly Val Pro Thr Pro Arg
    3730                3735                3740                
Ile Thr Trp Arg Lys Asp Gly Ala Val Leu Ala Gly Asn His Ala Arg
3745                3750                3755                3760
Tyr Ser Ile Leu Glu Asn Gly Phe Leu His Ile Gln Ser Ala His Val
                3765                3770                3775    
Thr Asp Thr Gly Arg Tyr Leu Cys Met Ala Thr Asn Ala Ala Gly Thr
            3780                3785                3790        
Asp Arg Arg Arg Ile Asp Leu Gln Val His Val Pro Pro Ser Ile Ala
        3795                3800                3805            
Pro Gly Pro Thr Asn Met Thr Val Ile Val Asn Val Gln Thr Thr Leu
    3810                3815                3820                
Ala Cys Glu Ala Thr Gly Ile Pro Lys Pro Ser Ile Asn Trp Arg Lys
3825                3830                3835                3840
Asn Gly His Leu Leu Asn Val Asp Gln Asn Gln Asn Ser Tyr Arg Leu
                3845                3850                3855    
Leu Ser Ser Gly Ser Leu Val Ile Ile Ser Pro Ser Val Asp Asp Thr
            3860                3865                3870        
Ala Thr Tyr Glu Cys Thr Val Thr Asn Gly Ala Gly Asp Asp Lys Arg
        3875                3880                3885            
Thr Val Asp Leu Thr Val Gln Val Pro Pro Ser Ile Ala Asp Glu Pro
    3890                3895                3900                
Thr Asp Phe Leu Val Thr Lys His Ala Pro Ala Val Ile Thr Cys Thr
3905                3910                3915                3920
Ala Ser Gly Val Pro Phe Pro Ser Ile His Trp Thr Lys Asn Gly Ile
                3925                3930                3935    
Arg Leu Leu Pro Arg Gly Asp Gly Tyr Arg Ile Leu Ser Ser Gly Ala
            3940                3945                3950        
Ile Glu Ile Leu Ala Thr Gln Leu Asn His Ala Gly Arg Tyr Thr Cys
        3955                3960                3965            
Val Ala Arg Asn Ala Ala Gly Ser Ala His Arg His Val Thr Leu His
    3970                3975                3980                
Val His Glu Pro Pro Val Ile Gln Pro Gln Pro Ser Glu Leu His Val
3985                3990                3995                4000
Ile Leu Asn Asn Pro Ile Leu Leu Pro Cys Glu Ala Thr Gly Thr Pro
                4005                4010                4015    
Ser Pro Phe Ile Thr Trp Gln Lys Glu Gly Ile Asn Val Asn Thr Ser
            4020                4025                4030        
Gly Arg Asn His Ala Val Leu Pro Ser Gly Gly Leu Gln Ile Ser Arg
        4035                4040                4045            
Ala Val Arg Glu Asp Ala Gly Thr Tyr Met Cys Val Ala Gln Asn Pro
    4050                4055                4060                
Ala Gly Thr Ala Leu Gly Lys Ile Lys Leu Asn Val Gln Val Pro Pro
4065                4070                4075                4080
Val Ile Ser Pro His Leu Lys Glu Tyr Val Ile Ala Val Asp Lys Pro
                4085                4090                4095    
Ile Thr Leu Ser Cys Glu Ala Asp Gly Leu Pro Pro Pro Asp Ile Thr
            4100                4105                4110        
Trp His Lys Asp Gly Arg Ala Ile Val Glu Ser Ile Arg Gln Arg Val
        4115                4120                4125            
Leu Ser Ser Gly Ser Leu Gln Ile Ala Phe Val Gln Pro Gly Asp Ala
    4130                4135                4140                
Gly His Tyr Thr Cys Met Ala Ala Asn Val Ala Gly Ser Ser Ser Thr
4145                4150                4155                4160
Ser Thr Lys Leu Thr Val His Val Pro Pro Arg Ile Arg Ser Thr Glu
                4165                4170                4175    
Gly His Tyr Thr Val Asn Glu Asn Ser Gln Ala Ile Leu Pro Cys Val
            4180                4185                4190        
Ala Asp Gly Ile Pro Thr Pro Ala Ile Asn Trp Lys Lys Asp Asn Val
        4195                4200                4205            
Leu Leu Ala Asn Leu Leu Gly Lys Tyr Thr Ala Glu Pro Tyr Gly Glu
    4210                4215                4220                
Leu Ile Leu Glu Asn Val Val Leu Glu Asp Ser Gly Phe Tyr Thr Cys
4225                4230                4235                4240
Val Ala Asn Asn Ala Ala Gly Glu Asp Thr His Thr Val Ser Leu Thr
                4245                4250                4255    
Val His Val Leu Pro Thr Phe Thr Glu Leu Pro Gly Asp Val Ser Leu
            4260                4265                4270        
Asn Lys Gly Glu Gln Leu Arg Leu Ser Cys Lys Ala Thr Gly Ile Pro
        4275                4280                4285            
Leu Pro Lys Leu Thr Trp Thr Phe Asn Asn Asn Ile Ile Pro Ala His
    4290                4295                4300                
Phe Asp Ser Val Asn Gly His Ser Glu Leu Val Ile Glu Arg Val Ser
4305                4310                4315                4320
Lys Glu Asp Ser Gly Thr Tyr Val Cys Thr Ala Glu Asn Ser Val Gly
                4325                4330                4335    
Phe Val Lys Ala Thr Gly Phe Val Tyr Val Lys Glu Pro Pro Val Phe
            4340                4345                4350        
Lys Gly Asp Tyr Pro Ser Asn Trp Ile Glu Pro Leu Gly Gly Asn Ala
        4355                4360                4365            
Ile Leu Asn Cys Glu Val Lys Gly Asp Pro Thr Pro Thr Ile Gln Trp
    4370                4375                4380                
Asn Arg Lys Gly Val Asp Ile Glu Ile Ser His Arg Ile Arg Gln Leu
4385                4390                4395                4400
Gly Asn Gly Ser Leu Ala Ile Tyr Gly Thr Val Asn Glu Asp Ala Gly
                4405                4410                4415    
Asp Tyr Thr Cys Val Ala Thr Asn Glu Ala Gly Val Val Glu Arg Ser
            4420                4425                4430        
Met Ser Leu Thr Leu Gln Ser Pro Pro Ile Ile Thr Leu Glu Pro Val
        4435                4440                4445            
Glu Thr Val Ile Asn Ala Gly Gly Lys Ile Ile Leu Asn Cys Gln Ala
    4450                4455                4460                
Thr Gly Glu Pro Gln Pro Thr Ile Thr Trp Ser Arg Gln Gly His Ser
4465                4470                4475                4480
Ile Ser Trp Asp Asp Arg Val Asn Val Leu Ser Asn Asn Ser Leu Tyr
                4485                4490                4495    
Ile Ala Asp Ala Gln Lys Glu Asp Thr Ser Glu Phe Glu Cys Val Ala
            4500                4505                4510        
Arg Asn Leu Met Gly Ser Val Leu Val Arg Val Pro Val Ile Val Gln
        4515                4520                4525            
Val His Gly Gly Phe Ser Gln Trp Ser Ala Trp Arg Ala Cys Ser Val
    4530                4535                4540                
Thr Cys Gly Lys Gly Ile Gln Lys Arg Ser Arg Leu Cys Asn Gln Pro
4545                4550                4555                4560
Leu Pro Ala Asn Gly Gly Lys Pro Cys Gln Gly Ser Asp Leu Glu Met
                4565                4570                4575    
Arg Asn Cys Gln Asn Lys Pro Cys Pro Val Asp Gly Ser Trp Ser Glu
            4580                4585                4590        
Trp Ser Leu Trp Glu Glu Cys Thr Arg Ser Cys Gly Arg Gly Asn Gln
        4595                4600                4605            
Thr Arg Thr Arg Thr Cys Asn Asn Pro Ser Val Gln His Gly Gly Arg
    4610                4615                4620                
Pro Cys Glu Gly Asn Ala Val Glu Ile Ile Met Cys Asn Ile Arg Pro
4625                4630                4635                4640
Cys Pro Val His Gly Ala Trp Ser Ala Trp Gln Pro Trp Gly Thr Cys
                4645                4650                4655    
Ser Glu Ser Cys Gly Lys Gly Thr Gln Thr Arg Ala Arg Leu Cys Asn
            4660                4665                4670        
Asn Pro Pro Pro Ala Phe Gly Gly Ser Tyr Cys Asp Gly Ala Glu Thr
        4675                4680                4685            
Gln Met Gln Val Cys Asn Glu Arg Asn Cys Pro Ile His Gly Lys Trp
    4690                4695                4700                
Ala Thr Trp Ala Ser Trp Ser Ala Cys Ser Val Ser Cys Gly Gly Gly
4705                4710                4715                4720
Ala Arg Gln Arg Thr Arg Gly Cys Ser Asp Pro Val Pro Gln Tyr Gly
                4725                4730                4735    
Gly Arg Lys Cys Glu Gly Ser Asp Val Gln Ser Asp Phe Cys Asn Ser
            4740                4745                4750        
Asp Pro Cys Pro Thr His Gly Asn Trp Ser Pro Trp Ser Gly Trp Gly
        4755                4760                4765            
Thr Cys Ser Arg Thr Cys Asn Gly Gly Gln Met Arg Arg Tyr Arg Thr
    4770                4775                4780                
Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly Arg Ala Cys Gly Gly Pro
4785                4790                4795                4800
Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp Met Cys Pro Val Asp Gly
                4805                4810                4815    
Ser Trp Gly Ser Trp His Ser Trp Ser Gln Cys Ser Ala Ser Cys Gly
            4820                4825                4830        
Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys Asp His Pro Val Pro Val
        4835                4840                4845            
Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr Thr Gln Val Thr Arg Cys
    4850                4855                4860                
Asn Val Gln Ala Cys Pro Gly Gly Pro Gln Arg Ala Arg Gly Ser Val
4865                4870                4875                4880
Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile Ala Phe Leu Asn Ala
                4885                4890                4895    
Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr Arg Ile Ile Arg Ala Lys
            4900                4905                4910        
Ile Thr Asn Val Pro Arg Ser Leu Gly Ser Ala Met Arg Lys Ile Val
        4915                4920                4925            
Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr Ala Lys Glu Ile Gly Glu
    4930                4935                4940                
Ala Val Asn Gly Phe Thr Leu Thr Asn Ala Val Phe Lys Arg Glu Thr
4945                4950                4955                4960
Gln Val Glu Phe Ala Thr Gly Glu Ile Leu Gln Met Ser His Ile Ala
                4965                4970                4975    
Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu Leu Asp Ile Val Val Ser
            4980                4985                4990        
Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala Glu Val Thr Val Lys Asp
        4995                5000                5005            
Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro Gly Gln Leu Tyr Ala Tyr
    5010                5015                5020                
Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile Ser Ile Pro Tyr Thr Trp
5025                5030                5035                5040
Asn His Thr Val Phe Tyr Asp Gln Ala Gln Gly Arg Met Pro Phe Leu
                5045                5050                5055    
Val Glu Thr Leu His Ala Ser Ser Val Glu Ser Asp Tyr Asn Gln Ile
            5060                5065                5070        
Glu Glu Thr Leu Gly Phe Lys Ile His Ala Ser Ile Ser Lys Gly Asp
        5075                5080                5085            
Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr Leu Asp Ser Val Gly Pro
    5090                5095                5100                
Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala Gly Asn Pro Cys Ser His
5105                5110                5115                5120
Ser Cys His Asn Ala Met Gly Thr Tyr Tyr Cys Ser Cys Pro Lys Gly
                5125                5130                5135    
Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys Gln Asp Ile Asp Glu Cys
            5140                5145                5150        
Ala Leu Gly Arg His Thr Cys His Ala Gly Gln Asp Cys Asp Asn Thr
        5155                5160                5165            
Ile Gly Ser Tyr Arg Cys Val Val Arg Cys Gly Ser Gly Phe Arg Arg
    5170                5175                5180                
Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile Asn Glu Cys Gln Glu Ser
5185                5190                5195                5200
Ser Pro Cys His Gln Arg Cys Phe Asn Ala Ile Gly Ser Phe His Cys
                5205                5210                5215    
Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly Arg Lys Cys Met Asp Val
            5220                5225                5230        
Asn Glu Cys Arg Gln Asn Val Cys Arg Pro Asp Gln His Cys Lys Asn
        5235                5240                5245            
Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu Cys Pro Asn Gly Met Thr
    5250                5255                5260                
Lys Ala Glu Asn Gly Thr Cys Ile Asp Ile Asp Glu Cys Lys Asp Gly
5265                5270                5275                5280
Thr His Gln Cys Arg Tyr Asn Gln Ile Cys Glu Asn Thr Arg Ser Ser
                5285                5290                5295    
Tyr Arg Cys Val Cys Pro Arg Gly Tyr Arg Ser Gln Gly Val Gly Arg
            5300                5305                5310        
Pro Cys Met Asp Ile Asp Glu Cys Glu Gln Val Pro Lys Pro Cys Ala
        5315                5320                5325            
His Gln Cys Ser Asn Thr Pro Gly Ser Phe Lys Cys Ile Cys Pro Pro
    5330                5335                5340                
Gly Gln His Leu Leu Gly Asp Gly Lys Ser Cys Ala Gly Leu Glu Arg
5345                5350                5355                5360
Leu Pro Asn Tyr Gly Thr Gln Tyr Ser Ser Tyr Asn Leu Ala Arg Phe
                5365                5370                5375    
Ser Pro Val Arg Asn Asn Tyr Gln Pro Gln Gln His Tyr Arg Gln Tyr
            5380                5385                5390        
Ser His Leu Tyr Ser Ser Tyr Ser Glu Tyr Arg Asn Ser Arg Thr Ser
        5395                5400                5405            
Leu Ser Arg Thr Arg Arg Thr Ile Arg Lys Thr Cys Pro Glu Gly Ser
    5410                5415                5420                
Glu Ala Ser His Asp Thr Cys Val Asp Ile Asp Glu Cys Glu Asn Thr
5425                5430                5435                5440
Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe Gly Ser Tyr Gln Cys
                5445                5450                5455    
Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn Gly Lys Thr Cys Gln
            5460                5465                5470        
Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His Cys Gly Pro Asn Arg
        5475                5480                5485            
Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys Ile Asp Thr Pro Cys
    5490                5495                5500                
Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly Phe Cys Leu Lys Asn
5505                5510                5515                5520
Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser Pro Tyr Ala Leu Glu
                5525                5530                5535    
Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala Thr Asn Gln Asp Leu
            5540                5545                5550        
Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val Met His Pro Arg Thr
        5555                5560                5565            
Thr Phe Leu Met Val Asp Glu Glu Gln Thr Val Pro Phe Ala Leu Arg
    5570                5575                5580                
Asp Glu Asn Leu Lys Gly Val Val Tyr Thr Thr Arg Pro Leu Arg Glu
5585                5590                5595                5600
Ala Glu Thr Tyr Arg Met Arg Val Arg Ala Ser Ser Tyr Ser Ala Asn
                5605                5610                5615    
Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile Val Tyr Ile Ala Val Ser
            5620                5625                5630        
Ala Tyr Pro Tyr
        5635    


<210> 6362
<211> 473
<212> PRT
<213> Homo sapiens

<400> 6362
Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala
 1               5                  10                  15      
Val Ala Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr
            20                  25                  30          
Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly
        35                  40                  45              
Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala
    50                  55                  60                  
Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg
65                  70                  75                  80  
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val
                85                  90                  95      
His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met
            100                 105                 110         
Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly
        115                 120                 125             
Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn
    130                 135                 140                 
Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala
145                 150                 155                 160 
Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln
                165                 170                 175     
Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg
            180                 185                 190         
Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe
        195                 200                 205             
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr
    210                 215                 220                 
Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp
225                 230                 235                 240 
Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu
                245                 250                 255     
Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val
            260                 265                 270         
Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu
        275                 280                 285             
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly
    290                 295                 300                 
Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu
305                 310                 315                 320 
Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser
                325                 330                 335     
Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val
            340                 345                 350         
Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala
        355                 360                 365             
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser
    370                 375                 380                 
Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His
385                 390                 395                 400 
Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala
                405                 410                 415     
Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly
            420                 425                 430         
Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly
        435                 440                 445             
Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu
    450                 455                 460                 
Ala Ala Leu Ala Phe Thr Trp Thr Leu
465                 470             


<210> 6363
<211> 1691
<212> PRT
<213> Homo sapiens

<400> 6363
Met Ala Ser Trp Thr Ser Pro Trp Trp Val Leu Ile Gly Met Val Phe
 1               5                  10                  15      
Met His Ser Pro Leu Pro Gln Thr Thr Ala Glu Lys Ser Pro Gly Ala
            20                  25                  30          
Tyr Phe Leu Pro Glu Phe Ala Leu Ser Pro Gln Gly Ser Phe Leu Glu
        35                  40                  45              
Asp Thr Thr Gly Glu Gln Phe Leu Thr Tyr Arg Tyr Asp Asp Gln Thr
    50                  55                  60                  
Ser Arg Asn Thr Arg Ser Asp Glu Asp Lys Asp Gly Asn Trp Asp Ala
65                  70                  75                  80  
Trp Gly Asp Trp Ser Asp Cys Ser Arg Thr Cys Gly Gly Gly Ala Ser
                85                  90                  95      
Tyr Ser Leu Arg Arg Cys Leu Thr Gly Arg Asn Cys Glu Gly Gln Asn
            100                 105                 110         
Ile Arg Tyr Lys Thr Cys Ser Asn His Asp Cys Pro Pro Asp Ala Glu
        115                 120                 125             
Asp Phe Arg Ala Gln Gln Cys Ser Ala Tyr Asn Asp Val Gln Tyr Gln
    130                 135                 140                 
Gly His Tyr Tyr Glu Trp Leu Pro Arg Tyr Asn Asp Pro Ala Ala Pro
145                 150                 155                 160 
Cys Ala Leu Lys Cys His Ala Gln Gly Gln Asn Leu Val Val Glu Leu
                165                 170                 175     
Ala Pro Lys Val Leu Asp Gly Thr Arg Cys Asn Thr Asp Ser Leu Asp
            180                 185                 190         
Met Cys Ile Ser Gly Ile Cys Gln Ala Val Gly Cys Asp Arg Gln Leu
        195                 200                 205             
Gly Ser Asn Ala Lys Glu Asp Asn Cys Gly Val Cys Ala Gly Asp Gly
    210                 215                 220                 
Ser Thr Cys Arg Leu Val Arg Gly Gln Ser Lys Ser His Val Ser Pro
225                 230                 235                 240 
Glu Lys Arg Glu Glu Asn Val Ile Ala Val Pro Leu Gly Ser Arg Ser
                245                 250                 255     
Val Arg Ile Thr Val Lys Gly Pro Ala His Leu Phe Ile Glu Ser Lys
            260                 265                 270         
Thr Leu Gln Gly Ser Lys Gly Glu His Ser Phe Asn Ser Pro Gly Val
        275                 280                 285             
Phe Leu Val Glu Asn Thr Thr Val Glu Phe Gln Arg Gly Ser Glu Arg
    290                 295                 300                 
Gln Thr Phe Lys Ile Pro Gly Pro Leu Met Ala Asp Phe Ile Phe Lys
305                 310                 315                 320 
Thr Arg Tyr Thr Ala Ala Lys Asp Ser Val Val Gln Phe Phe Phe Tyr
                325                 330                 335     
Gln Pro Ile Ser His Gln Trp Arg Gln Thr Asp Phe Phe Pro Cys Thr
            340                 345                 350         
Val Thr Cys Gly Gly Gly Tyr Gln Leu Asn Ser Ala Glu Cys Val Asp
        355                 360                 365             
Ile Arg Leu Lys Arg Val Val Pro Asp His Tyr Cys His Tyr Tyr Pro
    370                 375                 380                 
Glu Asn Val Lys Pro Lys Pro Lys Leu Lys Glu Cys Ser Met Asp Pro
385                 390                 395                 400 
Cys Pro Ser Ser Asp Gly Phe Lys Glu Ile Met Pro Tyr Asp His Phe
                405                 410                 415     
Gln Pro Leu Pro Arg Trp Glu His Asn Pro Trp Thr Ala Cys Ser Val
            420                 425                 430         
Ser Cys Gly Gly Gly Ile Gln Arg Arg Ser Phe Val Cys Val Glu Glu
        435                 440                 445             
Ser Met His Gly Glu Ile Leu Gln Val Glu Glu Trp Lys Cys Met Tyr
    450                 455                 460                 
Ala Pro Lys Pro Lys Val Met Gln Thr Cys Asn Leu Phe Asp Cys Pro
465                 470                 475                 480 
Lys Trp Ile Ala Met Glu Trp Ser Gln Cys Thr Val Thr Cys Gly Arg
                485                 490                 495     
Gly Leu Arg Tyr Arg Val Val Leu Cys Ile Asn His Arg Gly Glu His
            500                 505                 510         
Val Gly Gly Cys Asn Pro Gln Leu Lys Leu His Ile Lys Glu Glu Cys
        515                 520                 525             
Val Ile Pro Ile Pro Cys Tyr Lys Pro Lys Glu Lys Ser Pro Val Glu
    530                 535                 540                 
Ala Lys Leu Pro Trp Leu Lys Gln Ala Gln Glu Leu Glu Glu Thr Arg
545                 550                 555                 560 
Ile Ala Thr Glu Glu Pro Thr Phe Ile Pro Glu Pro Trp Ser Ala Cys
                565                 570                 575     
Ser Thr Thr Cys Gly Pro Gly Val Gln Val Arg Glu Val Lys Cys Arg
            580                 585                 590         
Val Leu Leu Thr Phe Thr Gln Thr Glu Thr Glu Leu Pro Glu Glu Glu
        595                 600                 605             
Cys Glu Gly Pro Lys Leu Pro Thr Glu Arg Pro Cys Leu Leu Glu Ala
    610                 615                 620                 
Cys Asp Glu Ser Pro Ala Ser Arg Glu Leu Asp Ile Pro Leu Pro Glu
625                 630                 635                 640 
Asp Ser Glu Thr Thr Tyr Asp Trp Glu Tyr Ala Gly Phe Thr Pro Cys
                645                 650                 655     
Thr Ala Thr Cys Val Gly Gly His Gln Glu Ala Ile Ala Val Cys Leu
            660                 665                 670         
His Ile Gln Thr Gln Gln Thr Val Asn Asp Ser Leu Cys Asp Met Val
        675                 680                 685             
His Arg Pro Pro Ala Met Ser Gln Ala Cys Asn Thr Glu Pro Cys Pro
    690                 695                 700                 
Pro Arg Trp His Val Gly Ser Trp Gly Pro Cys Ser Ala Thr Cys Gly
705                 710                 715                 720 
Val Gly Ile Gln Thr Arg Asp Val Tyr Cys Leu His Pro Gly Glu Thr
                725                 730                 735     
Pro Ala Pro Pro Glu Glu Cys Arg Asp Glu Lys Pro His Ala Leu Gln
            740                 745                 750         
Ala Cys Asn Gln Phe Asp Cys Pro Pro Gly Trp His Ile Glu Glu Trp
        755                 760                 765             
Gln Gln Cys Ser Arg Thr Cys Gly Gly Gly Thr Gln Asn Arg Arg Val
    770                 775                 780                 
Thr Cys Arg Gln Leu Leu Thr Asp Gly Ser Phe Leu Asn Leu Ser Asp
785                 790                 795                 800 
Glu Leu Cys Gln Gly Pro Lys Ala Ser Ser His Lys Ser Cys Ala Arg
                805                 810                 815     
Thr Asp Cys Pro Pro His Leu Ala Val Gly Asp Trp Ser Lys Cys Ser
            820                 825                 830         
Val Ser Cys Gly Val Gly Ile Gln Arg Arg Lys Gln Val Cys Gln Arg
        835                 840                 845             
Leu Ala Ala Lys Gly Arg Arg Ile Pro Leu Ser Glu Met Met Cys Arg
    850                 855                 860                 
Asp Leu Pro Gly Leu Pro Leu Val Arg Ser Cys Gln Met Pro Glu Cys
865                 870                 875                 880 
Ser Lys Ile Lys Ser Glu Met Lys Thr Lys Leu Gly Glu Gln Gly Pro
                885                 890                 895     
Gln Ile Leu Ser Val Gln Arg Val Tyr Ile Gln Thr Arg Glu Glu Lys
            900                 905                 910         
Arg Ile Asn Leu Thr Ile Gly Ser Arg Ala Tyr Leu Leu Pro Asn Thr
        915                 920                 925             
Ser Val Ile Ile Lys Cys Pro Val Arg Arg Phe Gln Lys Ser Leu Ile
    930                 935                 940                 
Gln Trp Glu Lys Asp Gly Arg Cys Leu Gln Asn Ser Lys Arg Leu Gly
945                 950                 955                 960 
Ile Thr Lys Ser Gly Ser Leu Lys Ile His Gly Leu Ala Ala Pro Asp
                965                 970                 975     
Ile Gly Val Tyr Arg Cys Ile Ala Gly Ser Ala Gln Glu Thr Val Val
            980                 985                 990         
Leu Lys Leu Ile Gly Thr Asp Asn Arg Leu Ile Ala Arg Pro Ala Leu
        995                 1000                1005            
Arg Glu Pro Met Arg Glu Tyr Pro Gly Met Asp His Ser Glu Ala Asn
    1010                1015                1020                
Ser Leu Gly Val Thr Trp His Lys Met Arg Gln Met Trp Asn Asn Lys
1025                1030                1035                1040
Asn Asp Leu Tyr Leu Asp Asp Asp His Ile Ser Asn Gln Pro Phe Leu
                1045                1050                1055    
Arg Ala Leu Leu Gly His Cys Ser Asn Ser Ala Gly Ser Thr Asn Ser
            1060                1065                1070        
Trp Glu Leu Lys Asn Lys Gln Phe Glu Ala Ala Val Lys Gln Gly Ala
        1075                1080                1085            
Tyr Ser Met Asp Thr Ala Gln Phe Asp Glu Leu Ile Arg Asn Met Ser
    1090                1095                1100                
Gln Leu Met Glu Thr Gly Glu Val Ser Asp Asp Leu Ala Ser Gln Leu
1105                1110                1115                1120
Ile Tyr Gln Leu Val Ala Glu Leu Ala Lys Ala Gln Pro Thr His Met
                1125                1130                1135    
Gln Trp Arg Gly Ile Gln Glu Glu Thr Pro Pro Ala Ala Gln Leu Arg
            1140                1145                1150        
Gly Glu Thr Gly Ser Val Ser Gln Ser Ser His Ala Lys Asn Ser Gly
        1155                1160                1165            
Lys Leu Thr Phe Lys Pro Lys Gly Pro Val Leu Met Arg Gln Ser Gln
    1170                1175                1180                
Pro Pro Ser Ile Ser Phe Asn Lys Thr Ile Asn Ser Arg Ile Gly Asn
1185                1190                1195                1200
Thr Val Tyr Ile Thr Lys Arg Thr Glu Val Ile Asn Ile Leu Cys Asp
                1205                1210                1215    
Leu Ile Thr Pro Ser Glu Ala Thr Tyr Thr Trp Thr Lys Asp Gly Thr
            1220                1225                1230        
Leu Leu Gln Pro Ser Val Lys Ile Ile Leu Asp Gly Thr Gly Lys Ile
        1235                1240                1245            
Gln Ile Gln Asn Pro Thr Arg Lys Glu Gln Gly Ile Tyr Glu Cys Ser
    1250                1255                1260                
Val Ala Asn His Leu Gly Ser Asp Val Glu Ser Ser Ser Val Leu Tyr
1265                1270                1275                1280
Ala Glu Ala Pro Val Ile Leu Ser Val Glu Arg Asn Ile Thr Lys Pro
                1285                1290                1295    
Glu His Asn His Leu Ser Val Val Val Gly Gly Ile Val Glu Ala Ala
            1300                1305                1310        
Leu Gly Ala Asn Val Thr Ile Arg Cys Pro Val Lys Gly Val Pro Gln
        1315                1320                1325            
Pro Asn Ile Thr Trp Leu Lys Arg Gly Gly Ser Leu Ser Gly Asn Val
    1330                1335                1340                
Ser Leu Leu Phe Asn Gly Ser Leu Leu Leu Gln Asn Val Ser Leu Glu
1345                1350                1355                1360
Asn Glu Gly Thr Tyr Val Cys Ile Ala Thr Asn Ala Leu Gly Lys Ala
                1365                1370                1375    
Val Ala Thr Ser Val Leu His Leu Leu Glu Arg Arg Trp Pro Glu Ser
            1380                1385                1390        
Arg Ile Val Phe Leu Gln Gly His Lys Lys Tyr Ile Leu Gln Ala Thr
        1395                1400                1405            
Asn Thr Arg Thr Asn Ser Asn Asp Pro Thr Gly Glu Pro Pro Pro Gln
    1410                1415                1420                
Glu Pro Phe Trp Glu Pro Gly Asn Trp Ser His Cys Ser Ala Thr Cys
1425                1430                1435                1440
Gly His Leu Gly Ala Arg Ile Gln Arg Pro Gln Cys Val Met Ala Asn
                1445                1450                1455    
Gly Gln Glu Val Ser Glu Ala Leu Cys Asp His Leu Gln Lys Pro Leu
            1460                1465                1470        
Ala Gly Phe Glu Pro Cys Asn Ile Arg Asp Cys Pro Ala Arg Trp Phe
        1475                1480                1485            
Thr Ser Val Trp Ser Gln Cys Ser Val Ser Cys Gly Glu Gly Tyr His
    1490                1495                1500                
Ser Arg Gln Val Thr Cys Lys Arg Thr Lys Ala Asn Gly Thr Val Gln
1505                1510                1515                1520
Val Val Ser Pro Arg Ala Cys Ala Pro Lys Asp Arg Pro Leu Gly Arg
                1525                1530                1535    
Lys Pro Cys Phe Gly His Pro Cys Val Gln Trp Glu Pro Gly Asn Arg
            1540                1545                1550        
Cys Pro Gly Arg Cys Met Gly Arg Ala Val Arg Met Gln Gln Arg His
        1555                1560                1565            
Thr Ala Cys Gln His Asn Ser Ser Asp Ser Asn Cys Asp Asp Arg Lys
    1570                1575                1580                
Arg Pro Thr Leu Arg Arg Asn Cys Thr Ser Gly Ala Cys Asp Val Cys
1585                1590                1595                1600
Trp His Thr Gly Pro Trp Lys Pro Cys Thr Ala Ala Cys Gly Arg Gly
                1605                1610                1615    
Phe Gln Ser Arg Lys Val Asp Cys Ile His Thr Arg Ser Cys Lys Pro
            1620                1625                1630        
Val Ala Lys Arg His Cys Val Gln Lys Lys Lys Pro Ile Ser Trp Arg
        1635                1640                1645            
His Cys Leu Gly Pro Ser Cys Asp Arg Asp Cys Thr Asp Thr Thr His
    1650                1655                1660                
Tyr Cys Met Phe Val Lys His Leu Asn Leu Cys Ser Leu Asp Arg Tyr
1665                1670                1675                1680
Lys Gln Arg Cys Cys Gln Ser Cys Gln Glu Gly
                1685                1690    


<210> 6364
<211> 866
<212> PRT
<213> Homo sapiens

<400> 6364
Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr
 1               5                  10                  15      
Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly
            20                  25                  30          
Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys
        35                  40                  45              
Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys
    50                  55                  60                  
Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp
65                  70                  75                  80  
Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln
                85                  90                  95      
Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile
            100                 105                 110         
Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn
        115                 120                 125             
Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys
    130                 135                 140                 
Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg
145                 150                 155                 160 
Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys
                165                 170                 175     
Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val
            180                 185                 190         
Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile
        195                 200                 205             
Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile
    210                 215                 220                 
Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln
225                 230                 235                 240 
Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln
                245                 250                 255     
Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly
            260                 265                 270         
Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn
        275                 280                 285             
Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser
    290                 295                 300                 
Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr
305                 310                 315                 320 
Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser
                325                 330                 335     
Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro
            340                 345                 350         
Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly
        355                 360                 365             
Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly
    370                 375                 380                 
Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser
385                 390                 395                 400 
Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val
                405                 410                 415     
Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys
            420                 425                 430         
Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys
        435                 440                 445             
Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr
    450                 455                 460                 
Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys
465                 470                 475                 480 
Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp
                485                 490                 495     
Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg
            500                 505                 510         
His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr
        515                 520                 525             
Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr
    530                 535                 540                 
Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser
545                 550                 555                 560 
Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser
                565                 570                 575     
Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly
            580                 585                 590         
Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly
        595                 600                 605             
Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala
    610                 615                 620                 
Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro
625                 630                 635                 640 
Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser
                645                 650                 655     
Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp
            660                 665                 670         
Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr
        675                 680                 685             
Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu
    690                 695                 700                 
Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg
705                 710                 715                 720 
Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala
                725                 730                 735     
Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala
            740                 745                 750         
Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu
        755                 760                 765             
Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln
    770                 775                 780                 
Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala
785                 790                 795                 800 
Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn
                805                 810                 815     
Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn
            820                 825                 830         
Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly
        835                 840                 845             
Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val
    850                 855                 860                 
Thr Gln
865     


<210> 6365
<211> 346
<212> PRT
<213> Homo sapiens

<400> 6365
Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile
 1               5                  10                  15      
Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His
            20                  25                  30          
Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu
        35                  40                  45              
Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser
    50                  55                  60                  
Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln
65                  70                  75                  80  
Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr
                85                  90                  95      
Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met
            100                 105                 110         
Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile
        115                 120                 125             
Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val
    130                 135                 140                 
Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val
145                 150                 155                 160 
Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg
                165                 170                 175     
Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys
            180                 185                 190         
Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His
        195                 200                 205             
Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu
    210                 215                 220                 
Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu
225                 230                 235                 240 
Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly
                245                 250                 255     
Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser
            260                 265                 270         
Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu
        275                 280                 285             
Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn
    290                 295                 300                 
Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile
305                 310                 315                 320 
Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu
                325                 330                 335     
Met Lys Ile Arg Pro Glu Asp Phe Lys Pro
            340                 345     


<210> 6366
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 6366
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765             
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780                 
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800 
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815     
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830         
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845             
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp
    850                 855                 860                 
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys
865                 870                 875                 880 
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val
                885                 890                 895     
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys
            900                 905                 910         
Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp
        915                 920                 925             
Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala
    930                 935                 940                 
Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln
945                 950                 955                 960 
Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His
                965                 970                 975     
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr
            980                 985                 990         
Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro
        995                 1000                1005            
Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val
    1010                1015                1020                
Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser
1025                1030                1035                1040
Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser
                1045                1050                1055    
Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly
            1060                1065                1070        
Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His
        1075                1080                1085            
Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys
    1090                1095                1100                
Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu
1105                1110                1115                1120
Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His
                1125                1130                1135    
Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser
            1140                1145                1150        
Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe
        1155                1160                1165            
Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe
    1170                1175                1180                
Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe
1185                1190                1195                1200
Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe
                1205                1210                1215    
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys
            1220                1225                1230        
Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys
        1235                1240                1245            
Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser
    1250                1255                1260                
Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr Arg Gly
1265                1270                1275                1280
Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu
                1285                1290                1295    
Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu
            1300                1305                1310        
Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro
        1315                1320                1325            
Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe
    1330                1335                1340                
Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys
1345                1350                1355                1360
Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp
                1365                1370                1375    
Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
            1380                1385                1390


<210> 6367
<211> 1408
<212> PRT
<213> Homo sapiens

<400> 6367
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu
        755                 760                 765             
Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn
    770                 775                 780                 
Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala
785                 790                 795                 800 
Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile
                805                 810                 815     
Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro
            820                 825                 830         
Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr
        835                 840                 845             
Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys
    850                 855                 860                 
Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly
865                 870                 875                 880 
Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly
                885                 890                 895     
Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys
            900                 905                 910         
Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu
        915                 920                 925             
Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln
    930                 935                 940                 
Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser
945                 950                 955                 960 
Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg
                965                 970                 975     
Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg
            980                 985                 990         
Val His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser
        995                 1000                1005            
Pro Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr
    1010                1015                1020                
Phe Pro Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg
1025                1030                1035                1040
Gln Val Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly
                1045                1050                1055    
Asp Ser Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp
            1060                1065                1070        
Leu Ser Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val
        1075                1080                1085            
Ile Gly Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg
    1090                1095                1100                
Gly His Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly
1105                1110                1115                1120
Lys Lys Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile
                1125                1130                1135    
Gly Glu Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe
            1140                1145                1150        
Ser His Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu
        1155                1160                1165            
Gly Ser Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg
    1170                1175                1180                
Asn Phe Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile
1185                1190                1195                1200
Gly Phe Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys
                1205                1210                1215    
Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu
            1220                1225                1230        
Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr
        1235                1240                1245            
Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro
    1250                1255                1260                
Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr
1265                1270                1275                1280
Lys Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr
                1285                1290                1295    
Arg Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val
            1300                1305                1310        
Tyr Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp
        1315                1320                1325            
Pro Leu Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met
    1330                1335                1340                
Arg Pro Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser
1345                1350                1355                1360
Thr Phe Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn
                1365                1370                1375    
Val Lys Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn
            1380                1385                1390        
Ala Asp Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
        1395                1400                1405            


<210> 6368
<211> 1523
<212> PRT
<213> Homo sapiens

<400> 6368
Met Ala Pro Gly Trp Ala Gly Val Gly Ala Ala Val Arg Ala Arg Leu
 1               5                  10                  15      
Ala Leu Ala Leu Ala Leu Ala Ser Val Leu Ser Gly Pro Pro Ala Val
            20                  25                  30          
Ala Cys Pro Thr Lys Cys Thr Cys Ser Ala Ala Ser Val Asp Cys His
        35                  40                  45              
Gly Leu Gly Leu Arg Ala Val Pro Arg Gly Ile Pro Arg Asn Ala Glu
    50                  55                  60                  
Arg Leu Asp Leu Asp Arg Asn Asn Ile Thr Arg Ile Thr Lys Met Asp
65                  70                  75                  80  
Phe Ala Gly Leu Lys Asn Leu Arg Val Leu His Leu Glu Asp Asn Gln
                85                  90                  95      
Val Ser Val Ile Glu Arg Gly Ala Phe Gln Asp Leu Lys Gln Leu Glu
            100                 105                 110         
Arg Leu Arg Leu Asn Lys Asn Lys Leu Gln Val Leu Pro Glu Leu Leu
        115                 120                 125             
Phe Gln Ser Thr Pro Lys Leu Thr Arg Leu Asp Leu Ser Glu Asn Gln
    130                 135                 140                 
Ile Gln Gly Ile Pro Arg Lys Ala Phe Arg Gly Ile Thr Asp Val Lys
145                 150                 155                 160 
Asn Leu Gln Leu Asp Asn Asn His Ile Ser Cys Ile Glu Asp Gly Ala
                165                 170                 175     
Phe Arg Ala Leu Arg Asp Leu Glu Ile Leu Thr Leu Asn Asn Asn Asn
            180                 185                 190         
Ile Ser Arg Ile Leu Val Thr Ser Phe Asn His Met Pro Lys Ile Arg
        195                 200                 205             
Thr Leu Arg Leu His Ser Asn His Leu Tyr Cys Asp Cys His Leu Ala
    210                 215                 220                 
Trp Leu Ser Asp Trp Leu Arg Gln Arg Arg Thr Val Gly Gln Phe Thr
225                 230                 235                 240 
Leu Cys Met Ala Pro Val His Leu Arg Gly Phe Asn Val Ala Asp Val
                245                 250                 255     
Gln Lys Lys Glu Tyr Val Cys Pro Ala Pro His Ser Glu Pro Pro Ser
            260                 265                 270         
Cys Asn Ala Asn Ser Ile Ser Cys Pro Ser Pro Cys Thr Cys Ser Asn
        275                 280                 285             
Asn Ile Val Asp Cys Arg Gly Lys Gly Leu Met Glu Ile Pro Ala Asn
    290                 295                 300                 
Leu Pro Glu Gly Ile Val Glu Ile Arg Leu Glu Gln Asn Ser Ile Lys
305                 310                 315                 320 
Ala Ile Pro Ala Gly Ala Phe Thr Gln Tyr Lys Lys Leu Lys Arg Ile
                325                 330                 335     
Asp Ile Ser Lys Asn Gln Ile Ser Asp Ile Ala Pro Asp Ala Phe Gln
            340                 345                 350         
Gly Leu Lys Ser Leu Thr Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr
        355                 360                 365             
Glu Ile Ala Lys Gly Leu Phe Asp Gly Leu Val Ser Leu Gln Leu Leu
    370                 375                 380                 
Leu Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asn Thr Phe Gln
385                 390                 395                 400 
Asp Leu Gln Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln
                405                 410                 415     
Thr Ile Ser Lys Gly Leu Phe Ala Pro Leu Gln Ser Ile Gln Thr Leu
            420                 425                 430         
His Leu Ala Gln Asn Pro Phe Val Cys Asp Cys His Leu Lys Trp Leu
        435                 440                 445             
Ala Asp Tyr Leu Gln Asp Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys
    450                 455                 460                 
Ser Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Ser Gln Ile Lys Ser
465                 470                 475                 480 
Lys Lys Phe Arg Cys Ser Gly Ser Glu Asp Tyr Arg Ser Arg Phe Ser
                485                 490                 495     
Ser Glu Cys Phe Met Asp Leu Val Cys Pro Glu Lys Cys Arg Cys Glu
            500                 505                 510         
Gly Thr Ile Val Asp Cys Ser Asn Gln Lys Leu Val Arg Ile Pro Ser
        515                 520                 525             
His Leu Pro Glu Tyr Val Thr Asp Leu Arg Leu Asn Asp Asn Glu Val
    530                 535                 540                 
Ser Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Asn Leu Arg
545                 550                 555                 560 
Lys Ile Asn Leu Ser Asn Asn Lys Ile Lys Glu Val Arg Glu Gly Ala
                565                 570                 575     
Phe Asp Gly Ala Ala Ser Val Gln Glu Leu Met Leu Thr Gly Asn Gln
            580                 585                 590         
Leu Glu Thr Val His Gly Arg Val Phe Arg Gly Leu Ser Gly Leu Lys
        595                 600                 605             
Thr Leu Met Leu Arg Ser Asn Leu Ile Gly Cys Val Ser Asn Asp Thr
    610                 615                 620                 
Phe Ala Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn Arg
625                 630                 635                 640 
Ile Thr Thr Ile Thr Pro Gly Ala Phe Thr Thr Leu Val Ser Leu Ser
                645                 650                 655     
Thr Ile Asn Leu Leu Ser Asn Pro Phe Asn Cys Asn Cys His Leu Ala
            660                 665                 670         
Trp Leu Gly Lys Trp Leu Arg Lys Arg Arg Ile Val Ser Gly Asn Pro
        675                 680                 685             
Arg Cys Gln Lys Pro Phe Phe Leu Lys Glu Ile Pro Ile Gln Asp Val
    690                 695                 700                 
Ala Ile Gln Asp Phe Thr Cys Asp Gly Asn Glu Glu Ser Ser Cys Gln
705                 710                 715                 720 
Leu Ser Pro Arg Cys Pro Glu Gln Cys Thr Cys Met Glu Thr Val Val
                725                 730                 735     
Arg Cys Ser Asn Lys Gly Leu Arg Ala Leu Pro Arg Gly Met Pro Lys
            740                 745                 750         
Asp Val Thr Glu Leu Tyr Leu Glu Gly Asn His Leu Thr Ala Val Pro
        755                 760                 765             
Arg Glu Leu Ser Ala Leu Arg His Leu Thr Leu Ile Asp Leu Ser Asn
    770                 775                 780                 
Asn Ser Ile Ser Met Leu Thr Asn Tyr Thr Phe Ser Asn Met Ser His
785                 790                 795                 800 
Leu Ser Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile Pro Val
                805                 810                 815     
His Ala Phe Asn Gly Leu Arg Ser Leu Arg Val Leu Thr Leu His Gly
            820                 825                 830         
Asn Asp Ile Ser Ser Val Pro Glu Gly Ser Phe Asn Asp Leu Thr Ser
        835                 840                 845             
Leu Ser His Leu Ala Leu Gly Thr Asn Pro Leu His Cys Asp Cys Ser
    850                 855                 860                 
Leu Arg Trp Leu Ser Glu Trp Val Lys Ala Gly Tyr Lys Glu Pro Gly
865                 870                 875                 880 
Ile Ala Arg Cys Ser Ser Pro Glu Pro Met Ala Asp Arg Leu Leu Leu
                885                 890                 895     
Thr Thr Pro Thr His Arg Phe Gln Cys Lys Gly Pro Val Asp Ile Asn
            900                 905                 910         
Ile Val Ala Lys Cys Asn Ala Cys Leu Ser Ser Pro Cys Lys Asn Asn
        915                 920                 925             
Gly Thr Cys Thr Gln Asp Pro Val Glu Leu Tyr Arg Cys Ala Cys Pro
    930                 935                 940                 
Tyr Ser Tyr Lys Gly Lys Asp Cys Thr Val Pro Ile Asn Thr Cys Ile
945                 950                 955                 960 
Gln Asn Pro Cys Gln His Gly Gly Thr Cys His Leu Ser Asp Ser His
                965                 970                 975     
Lys Asp Gly Phe Ser Cys Ser Cys Pro Leu Gly Phe Glu Gly Gln Arg
            980                 985                 990         
Cys Glu Ile Asn Pro Asp Asp Cys Glu Asp Asn Asp Cys Glu Asn Asn
        995                 1000                1005            
Ala Thr Cys Val Asp Gly Ile Asn Asn Tyr Val Cys Ile Cys Pro Pro
    1010                1015                1020                
Asn Tyr Thr Gly Glu Leu Cys Asp Glu Val Ile Asp His Cys Val Pro
1025                1030                1035                1040
Glu Leu Asn Leu Cys Gln His Glu Ala Lys Cys Ile Pro Leu Asp Lys
                1045                1050                1055    
Gly Phe Ser Cys Glu Cys Val Pro Gly Tyr Ser Gly Lys Leu Cys Glu
            1060                1065                1070        
Thr Asp Asn Asp Asp Cys Val Ala His Lys Cys Arg His Gly Ala Gln
        1075                1080                1085            
Cys Val Asp Thr Ile Asn Gly Tyr Thr Cys Thr Cys Pro Gln Gly Phe
    1090                1095                1100                
Ser Gly Pro Phe Cys Glu His Pro Pro Pro Met Val Leu Leu Gln Thr
1105                1110                1115                1120
Ser Pro Cys Asp Gln Tyr Glu Cys Gln Asn Gly Ala Gln Cys Ile Val
                1125                1130                1135    
Val Gln Gln Glu Pro Thr Cys Arg Cys Pro Pro Gly Phe Ala Gly Pro
            1140                1145                1150        
Arg Cys Glu Lys Leu Ile Thr Val Asn Phe Val Gly Lys Asp Ser Tyr
        1155                1160                1165            
Val Glu Leu Ala Ser Ala Lys Val Arg Pro Gln Ala Asn Ile Ser Leu
    1170                1175                1180                
Gln Val Ala Thr Asp Lys Asp Asn Gly Ile Leu Leu Tyr Lys Gly Asp
1185                1190                1195                1200
Asn Asp Pro Leu Ala Leu Glu Leu Tyr Gln Gly His Val Arg Leu Val
                1205                1210                1215    
Tyr Asp Ser Leu Ser Ser Pro Pro Thr Thr Val Tyr Ser Val Glu Thr
            1220                1225                1230        
Val Asn Asp Gly Gln Phe His Ser Val Glu Leu Val Thr Leu Asn Gln
        1235                1240                1245            
Thr Leu Asn Leu Val Val Asp Lys Gly Thr Pro Lys Ser Leu Gly Lys
    1250                1255                1260                
Leu Gln Lys Gln Pro Ala Val Gly Ile Asn Ser Pro Leu Tyr Leu Gly
1265                1270                1275                1280
Gly Ile Pro Thr Ser Thr Gly Leu Ser Ala Leu Arg Gln Gly Thr Asp
                1285                1290                1295    
Arg Pro Leu Gly Gly Phe His Gly Cys Ile His Glu Val Arg Ile Asn
            1300                1305                1310        
Asn Glu Leu Gln Asp Phe Lys Ala Leu Pro Pro Gln Ser Leu Gly Val
        1315                1320                1325            
Ser Pro Gly Cys Lys Ser Cys Thr Val Cys Lys His Gly Leu Cys Arg
    1330                1335                1340                
Ser Val Glu Lys Asp Ser Val Val Cys Glu Cys Arg Pro Gly Trp Thr
1345                1350                1355                1360
Gly Pro Leu Cys Asp Gln Glu Ala Arg Asp Pro Cys Leu Gly His Arg
                1365                1370                1375    
Cys His His Gly Lys Cys Val Ala Thr Gly Thr Ser Tyr Met Cys Lys
            1380                1385                1390        
Cys Ala Glu Gly Tyr Gly Gly Asp Leu Cys Asp Asn Lys Asn Asp Ser
        1395                1400                1405            
Ala Asn Ala Cys Ser Ala Phe Lys Cys His His Gly Gln Cys His Ile
    1410                1415                1420                
Ser Asp Gln Gly Glu Pro Tyr Cys Leu Cys Gln Pro Gly Phe Ser Gly
1425                1430                1435                1440
Glu His Cys Gln Gln Glu Asn Pro Cys Leu Gly Gln Val Val Arg Glu
                1445                1450                1455    
Val Ile Arg Arg Gln Lys Gly Tyr Ala Ser Cys Ala Thr Ala Ser Lys
            1460                1465                1470        
Val Pro Ile Met Glu Cys Arg Gly Gly Cys Gly Pro Gln Cys Cys Gln
        1475                1480                1485            
Pro Thr Arg Ser Lys Arg Arg Lys Tyr Val Phe Gln Cys Thr Asp Gly
    1490                1495                1500                
Ser Ser Phe Val Glu Glu Val Glu Arg His Leu Glu Cys Gly Cys Leu
1505                1510                1515                1520
Ala Cys Ser
            


<210> 6369
<211> 850
<212> PRT
<213> Homo sapiens

<400> 6369
Glu Gly Ala Phe Asp Gly Ala Ala Ser Val Gln Glu Leu Met Leu Thr
 1               5                  10                  15      
Gly Asn Gln Leu Glu Thr Val His Gly Arg Val Phe Arg Gly Leu Ser
            20                  25                  30          
Gly Leu Lys Thr Leu Met Leu Arg Ser Asn Leu Ile Gly Cys Val Ser
        35                  40                  45              
Asn Asp Thr Phe Ala Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr
    50                  55                  60                  
Asp Asn Arg Ile Thr Thr Ile Thr Pro Gly Ala Phe Thr Thr Leu Val
65                  70                  75                  80  
Ser Leu Ser Thr Ile Asn Leu Leu Ser Asn Pro Phe Asn Cys Asn Cys
                85                  90                  95      
His Leu Ala Trp Leu Gly Lys Trp Leu Arg Lys Arg Arg Ile Val Ser
            100                 105                 110         
Gly Asn Pro Arg Cys Gln Lys Pro Phe Phe Leu Lys Glu Ile Pro Ile
        115                 120                 125             
Gln Asp Val Ala Ile Gln Asp Phe Thr Cys Asp Gly Asn Glu Glu Ser
    130                 135                 140                 
Ser Cys Gln Leu Ser Pro Arg Cys Pro Glu Gln Cys Thr Cys Met Glu
145                 150                 155                 160 
Thr Val Val Arg Cys Ser Asn Lys Gly Leu Arg Ala Leu Pro Arg Gly
                165                 170                 175     
Met Pro Lys Asp Val Thr Glu Leu Tyr Leu Glu Gly Asn His Leu Thr
            180                 185                 190         
Ala Val Pro Arg Glu Leu Ser Ala Leu Arg His Leu Thr Leu Ile Asp
        195                 200                 205             
Leu Ser Asn Asn Ser Ile Ser Met Leu Thr Asn Tyr Thr Phe Ser Asn
    210                 215                 220                 
Met Ser His Leu Ser Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys
225                 230                 235                 240 
Ile Pro Val His Ala Phe Asn Gly Leu Arg Ser Leu Arg Val Leu Thr
                245                 250                 255     
Leu His Gly Asn Asp Ile Ser Ser Val Pro Glu Gly Ser Phe Asn Asp
            260                 265                 270         
Leu Thr Ser Leu Ser His Leu Ala Leu Gly Thr Asn Pro Leu His Cys
        275                 280                 285             
Asp Cys Ser Leu Arg Trp Leu Ser Glu Trp Val Lys Ala Gly Tyr Lys
    290                 295                 300                 
Glu Pro Gly Ile Ala Arg Cys Ser Ser Pro Glu Pro Met Ala Asp Arg
305                 310                 315                 320 
Leu Leu Leu Thr Thr Pro Thr His Arg Phe Gln Cys Lys Gly Pro Val
                325                 330                 335     
Asp Ile Asn Ile Val Ala Lys Cys Asn Ala Cys Leu Ser Ser Pro Cys
            340                 345                 350         
Lys Asn Asn Gly Thr Cys Thr Gln Asp Pro Val Glu Leu Tyr Arg Cys
        355                 360                 365             
Ala Cys Pro Tyr Ser Tyr Lys Gly Lys Asp Cys Thr Val Pro Ile Asn
    370                 375                 380                 
Thr Cys Ile Gln Asn Pro Cys Gln His Gly Gly Thr Cys His Leu Ser
385                 390                 395                 400 
Asp Ser His Lys Asp Gly Phe Ser Cys Ser Cys Pro Leu Gly Phe Glu
                405                 410                 415     
Gly Gln Arg Cys Glu Ile Asn Pro Asp Asp Cys Glu Asp Asn Asp Cys
            420                 425                 430         
Glu Asn Asn Ala Thr Cys Val Asp Gly Ile Asn Asn Tyr Val Cys Ile
        435                 440                 445             
Cys Pro Pro Asn Tyr Thr Gly Glu Leu Cys Asp Glu Val Ile Asp His
    450                 455                 460                 
Cys Val Pro Glu Leu Asn Leu Cys Gln His Glu Ala Lys Cys Ile Pro
465                 470                 475                 480 
Leu Asp Lys Gly Phe Ser Cys Glu Cys Val Pro Gly Tyr Ser Gly Lys
                485                 490                 495     
Leu Cys Glu Thr Asp Asn Asp Asp Cys Val Ala His Lys Cys Arg His
            500                 505                 510         
Gly Ala Gln Cys Val Asp Thr Ile Asn Gly Tyr Thr Cys Thr Cys Pro
        515                 520                 525             
Gln Gly Phe Ser Gly Pro Phe Cys Glu His Pro Pro Pro Met Val Tyr
    530                 535                 540                 
Asp Ser Leu Ser Ser Pro Pro Thr Thr Val Tyr Ser Val Glu Thr Val
545                 550                 555                 560 
Asn Asp Gly Gln Phe His Ser Val Glu Leu Val Thr Leu Asn Gln Thr
                565                 570                 575     
Leu Asn Leu Val Val Asp Lys Gly Thr Pro Lys Ser Leu Gly Lys Leu
            580                 585                 590         
Gln Lys Gln Pro Ala Val Gly Ile Asn Ser Pro Leu Tyr Leu Gly Gly
        595                 600                 605             
Ile Pro Thr Ser Thr Gly Leu Ser Ala Leu Arg Gln Gly Thr Asp Arg
    610                 615                 620                 
Pro Leu Gly Gly Phe His Gly Cys Ile His Glu Val Arg Ile Asn Asn
625                 630                 635                 640 
Glu Leu Gln Asp Phe Lys Ala Leu Pro Pro Gln Ser Leu Gly Val Ser
                645                 650                 655     
Pro Gly Cys Lys Ser Cys Thr Val Cys Lys His Gly Leu Cys Arg Ser
            660                 665                 670         
Val Glu Lys Asp Ser Val Val Cys Glu Cys Arg Pro Gly Trp Thr Gly
        675                 680                 685             
Pro Leu Cys Asp Gln Glu Ala Arg Asp Pro Cys Leu Gly His Arg Cys
    690                 695                 700                 
His His Gly Lys Cys Val Ala Thr Gly Thr Ser Tyr Met Cys Lys Cys
705                 710                 715                 720 
Ala Glu Gly Tyr Gly Gly Asp Leu Cys Asp Asn Lys Asn Asp Ser Ala
                725                 730                 735     
Asn Ala Cys Ser Ala Phe Lys Cys His His Gly Gln Cys His Ile Ser
            740                 745                 750         
Asp Gln Gly Glu Pro Tyr Cys Leu Cys Gln Pro Gly Phe Ser Gly Glu
        755                 760                 765             
His Cys Gln Gln Glu Asn Pro Cys Leu Gly Gln Val Val Arg Glu Val
    770                 775                 780                 
Ile Arg Arg Gln Lys Gly Tyr Ala Ser Cys Ala Thr Ala Ser Lys Val
785                 790                 795                 800 
Pro Ile Met Glu Cys Arg Gly Gly Cys Gly Pro Gln Cys Cys Gln Pro
                805                 810                 815     
Thr Arg Ser Lys Arg Arg Lys Tyr Val Phe Gln Cys Thr Asp Gly Ser
            820                 825                 830         
Ser Phe Val Glu Glu Val Glu Arg His Leu Glu Cys Gly Cys Leu Ala
        835                 840                 845             
Cys Ser
    850 


<210> 6370
<211> 810
<212> PRT
<213> Homo sapiens

<400> 6370
Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser
 1               5                  10                  15      
Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser
            20                  25                  30          
Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu
        35                  40                  45              
Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe
    50                  55                  60                  
Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg
65                  70                  75                  80  
Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys
                85                  90                  95      
Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg
            100                 105                 110         
Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser
        115                 120                 125             
Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser
    130                 135                 140                 
Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln
145                 150                 155                 160 
Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys
                165                 170                 175     
Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn
            180                 185                 190         
Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala
        195                 200                 205             
Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe
    210                 215                 220                 
Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu
225                 230                 235                 240 
Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu
                245                 250                 255     
Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr
            260                 265                 270         
Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala
        275                 280                 285             
Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro
    290                 295                 300                 
His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp
305                 310                 315                 320 
Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His
                325                 330                 335     
Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys
            340                 345                 350         
Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro
        355                 360                 365             
Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser
    370                 375                 380                 
Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser
385                 390                 395                 400 
Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr
                405                 410                 415     
Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp
            420                 425                 430         
Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr
        435                 440                 445             
Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro
    450                 455                 460                 
Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp
465                 470                 475                 480 
Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr
                485                 490                 495     
Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg
            500                 505                 510         
His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys
        515                 520                 525             
Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr
    530                 535                 540                 
Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys
545                 550                 555                 560 
Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys
                565                 570                 575     
Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp
            580                 585                 590         
Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly
        595                 600                 605             
Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu
    610                 615                 620                 
Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His
625                 630                 635                 640 
Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg
                645                 650                 655     
Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser
            660                 665                 670         
Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser
        675                 680                 685             
Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp
    690                 695                 700                 
Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln
705                 710                 715                 720 
Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn
                725                 730                 735     
Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly
            740                 745                 750         
Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu
        755                 760                 765             
Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys
    770                 775                 780                 
Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val
785                 790                 795                 800 
Thr Trp Ile Glu Gly Val Met Arg Asn Asn
                805                 810 


<210> 6371
<211> 732
<212> PRT
<213> Homo sapiens

<400> 6371
Met Met Trp Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe
 1               5                  10                  15      
Ser Leu Ala Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr
            20                  25                  30          
Tyr Tyr Arg Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr
        35                  40                  45              
Ser Tyr Thr Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys
    50                  55                  60                  
His Asp Asn Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser
65                  70                  75                  80  
Cys Ser Phe Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile
                85                  90                  95      
Glu Val Glu Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr
            100                 105                 110         
Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe
        115                 120                 125             
Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp
    130                 135                 140                 
Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu
145                 150                 155                 160 
Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala
                165                 170                 175     
Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln
            180                 185                 190         
Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser
        195                 200                 205             
Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu
    210                 215                 220                 
Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu
225                 230                 235                 240 
Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly
                245                 250                 255     
Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro
            260                 265                 270         
Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln
        275                 280                 285             
Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser
    290                 295                 300                 
Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala
305                 310                 315                 320 
Ile Gln Glu Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val
                325                 330                 335     
Ala Glu Asp Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val
            340                 345                 350         
Asn Thr Trp Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr
        355                 360                 365             
Thr Leu Ser Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln
    370                 375                 380                 
Gln Asp Lys Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro
385                 390                 395                 400 
Met Leu His Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala
                405                 410                 415     
Lys Glu Gly Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile
            420                 425                 430         
Gly Val Lys Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu
        435                 440                 445             
Arg Lys Gly Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly
    450                 455                 460                 
Gly Lys Gly Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly
465                 470                 475                 480 
Leu Glu Ser Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala
                485                 490                 495     
Ser Thr Ser Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr
            500                 505                 510         
Leu Ser Phe Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly
        515                 520                 525             
Gly Gly Leu Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys
    530                 535                 540                 
Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro
545                 550                 555                 560 
Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys
                565                 570                 575     
Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile
            580                 585                 590         
Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu
        595                 600                 605             
Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala
    610                 615                 620                 
Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Tyr Val
625                 630                 635                 640 
Thr Cys Pro Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe Glu Glu
                645                 650                 655     
Leu Pro Val Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr Leu Arg
            660                 665                 670         
Ser Arg Met Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln Leu Leu
        675                 680                 685             
Phe Ser Gly Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu Gly Ala
    690                 695                 700                 
Pro Asn Pro Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe Leu Val
705                 710                 715                 720 
Ser Glu Lys Leu Pro Glu His Thr Lys Gly Glu Val
                725                 730         


<210> 6372
<211> 1103
<212> PRT
<213> Homo sapiens

<400> 6372
Met Thr Ala Cys Ala Arg Arg Ala Gly Gly Leu Pro Asp Pro Gly Leu
 1               5                  10                  15      
Cys Gly Pro Ala Trp Trp Ala Pro Ser Leu Pro Arg Leu Pro Arg Ala
            20                  25                  30          
Leu Pro Arg Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Pro
        35                  40                  45              
Ala Leu Ser Ala Val Phe Thr Val Gly Val Leu Gly Pro Trp Ala Cys
    50                  55                  60                  
Asp Pro Ile Phe Ser Arg Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala
65                  70                  75                  80  
Ala Ala Arg Leu Asn Arg Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe
                85                  90                  95      
Glu Val Ala Leu Leu Pro Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly
            100                 105                 110         
Ala Val Ser Ser Ala Leu Ala Arg Val Ser Gly Leu Val Gly Pro Val
        115                 120                 125             
Asn Pro Ala Ala Cys Arg Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly
    130                 135                 140                 
Ile Ala Leu Val Pro Trp Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr
145                 150                 155                 160 
Thr Ala Pro Ala Val Thr Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu
                165                 170                 175     
Arg Ala Phe Gly Trp Ala Arg Val Ala Leu Val Thr Ala Pro Gln Asp
            180                 185                 190         
Leu Trp Val Glu Ala Gly Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg
        195                 200                 205             
Gly Leu Pro Val Ala Ser Val Thr Ser Met Glu Pro Leu Asp Leu Ser
    210                 215                 220                 
Gly Ala Arg Glu Ala Leu Arg Lys Val Arg Asp Gly Pro Arg Val Thr
225                 230                 235                 240 
Ala Val Ile Met Val Met His Ser Val Leu Leu Gly Gly Glu Glu Gln
                245                 250                 255     
Arg Tyr Leu Leu Glu Ala Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser
            260                 265                 270         
Leu Val Phe Leu Pro Phe Asp Thr Ile His Tyr Ala Leu Ser Pro Gly
        275                 280                 285             
Pro Glu Ala Leu Ala Ala Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala
    290                 295                 300                 
His Asp Ala Val Leu Thr Leu Thr Arg His Cys Pro Ser Glu Gly Ser
305                 310                 315                 320 
Val Leu Asp Ser Leu Arg Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser
                325                 330                 335     
Asp Leu Asn Leu Gln Gln Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp
            340                 345                 350         
Ala Val Phe Leu Leu Ala Arg Gly Val Ala Glu Ala Arg Ala Ala Ala
        355                 360                 365             
Gly Gly Arg Trp Val Ser Gly Ala Ala Val Ala Arg His Ile Arg Asp
    370                 375                 380                 
Ala Gln Val Pro Gly Phe Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro
385                 390                 395                 400 
Pro Phe Val Leu Leu Asp Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala
                405                 410                 415     
Thr Tyr Met Leu Asp Pro Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr
            420                 425                 430         
Arg Met His Phe Pro Arg Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser
        435                 440                 445             
Cys Trp Phe Asp Pro Asn Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly
    450                 455                 460                 
Leu Val Phe Leu Gly Phe Leu Leu Val Val Gly Met Gly Leu Ala Gly
465                 470                 475                 480 
Ala Phe Leu Ala His Tyr Val Arg His Arg Leu Leu His Met Gln Met
                485                 490                 495     
Val Ser Gly Pro Asn Lys Ile Ile Leu Thr Val Asp Asp Ile Thr Phe
            500                 505                 510         
Leu His Pro His Gly Gly Thr Ser Arg Lys Val Ala Gln Gly Ser Arg
        515                 520                 525             
Ser Ser Leu Gly Ala Arg Ser Met Ser Asp Ile Arg Ser Gly Pro Ser
    530                 535                 540                 
Gln His Leu Asp Ser Pro Asn Ile Gly Val Tyr Glu Gly Asp Arg Val
545                 550                 555                 560 
Trp Leu Lys Lys Phe Pro Gly Asp Gln His Ile Ala Ile Arg Pro Ala
                565                 570                 575     
Thr Lys Thr Ala Phe Ser Lys Leu Gln Glu Leu Arg His Glu Asn Val
            580                 585                 590         
Ala Leu Tyr Leu Gly Leu Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala
        595                 600                 605             
Ala Leu Trp Glu Gly Asn Leu Ala Val Val Ser Glu His Cys Thr Arg
    610                 615                 620                 
Gly Ser Leu Gln Asp Leu Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp
625                 630                 635                 640 
Met Phe Lys Ser Ser Leu Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr
                645                 650                 655     
Leu His His Arg Gly Val Ala His Gly Arg Leu Lys Ser Arg Asn Cys
            660                 665                 670         
Ile Val Asp Gly Arg Phe Val Leu Lys Ile Thr Asp His Gly His Gly
        675                 680                 685             
Arg Leu Leu Glu Ala Gln Lys Val Leu Pro Glu Pro Pro Arg Ala Glu
    690                 695                 700                 
Asp Gln Leu Trp Thr Ala Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu
705                 710                 715                 720 
Arg Arg Gly Thr Leu Ala Gly Asp Val Phe Ser Leu Ala Ile Ile Met
                725                 730                 735     
Gln Glu Val Val Cys Arg Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr
            740                 745                 750         
Pro Glu Glu Val Val Gln Arg Val Arg Ser Pro Pro Pro Leu Cys Arg
        755                 760                 765             
Pro Leu Val Ser Met Asp Gln Ala Pro Val Glu Cys Ile Leu Leu Met
    770                 775                 780                 
Lys Gln Cys Trp Ala Glu Gln Pro Glu Leu Arg Pro Ser Met Asp His
785                 790                 795                 800 
Thr Phe Asp Leu Phe Lys Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile
                805                 810                 815     
Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu
            820                 825                 830         
Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys
        835                 840                 845             
Thr Asp Arg Leu Leu Thr Gln Met Leu Pro Pro Ser Val Ala Glu Ala
    850                 855                 860                 
Leu Lys Thr Gly Thr Pro Val Glu Pro Glu Tyr Phe Glu Gln Val Thr
865                 870                 875                 880 
Leu Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Ser Ala Met Ser
                885                 890                 895     
Glu Pro Ile Glu Val Val Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe
            900                 905                 910         
Asp Ala Ile Ile Gly Ser His Asp Val Tyr Lys Val Glu Thr Ile Gly
        915                 920                 925             
Asp Ala Tyr Met Val Ala Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg
    930                 935                 940                 
His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser Ala Val
945                 950                 955                 960 
Gly Thr Phe Arg Met Arg His Met Pro Glu Val Pro Val Arg Ile Arg
                965                 970                 975     
Ile Gly Leu His Ser Gly Pro Cys Val Ala Gly Val Val Gly Leu Thr
            980                 985                 990         
Met Pro Arg Tyr Cys Leu Phe Gly Asp Thr Val Asn Thr Ala Ser Arg
        995                 1000                1005            
Met Glu Ser Thr Gly Leu Pro Tyr Arg Ile His Val Asn Leu Ser Thr
    1010                1015                1020                
Val Gly Ile Leu Arg Ala Leu Asp Ser Gly Tyr Gln Val Glu Leu Arg
1025                1030                1035                1040
Gly Arg Thr Glu Leu Lys Gly Lys Gly Ala Glu Asp Thr Phe Trp Leu
                1045                1050                1055    
Val Gly Arg Arg Gly Phe Asn Lys Pro Ile Pro Lys Pro Pro Asp Leu
            1060                1065                1070        
Gln Pro Gly Ser Ser Asn His Gly Ile Ser Leu Gln Glu Ile Pro Pro
        1075                1080                1085            
Glu Arg Arg Arg Lys Leu Glu Lys Ala Arg Pro Gly Gln Phe Ser
    1090                1095                1100            


<210> 6373
<211> 1416
<212> PRT
<213> Homo sapiens

<400> 6373
Met Lys Ser Leu Lys Ser Arg Leu Arg Arg Gln Asp Val Pro Gly Pro
 1               5                  10                  15      
Ala Ser Ser Gly Ala Ala Ala Ala Ser Ala His Ala Ala Asp Trp Asn
            20                  25                  30          
Lys Tyr Asp Asp Arg Leu Met Lys Ala Ala Glu Arg Gly Asp Val Glu
        35                  40                  45              
Lys Val Thr Ser Ile Leu Ala Lys Lys Gly Val Asn Pro Gly Lys Leu
    50                  55                  60                  
Asp Val Glu Gly Arg Ser Val Phe His Val Val Thr Ser Lys Gly Asn
65                  70                  75                  80  
Leu Glu Cys Leu Asn Ala Ile Leu Ile His Gly Val Asp Ile Thr Thr
                85                  90                  95      
Ser Asp Thr Ala Gly Arg Asn Ala Leu His Leu Ala Ala Lys Tyr Gly
            100                 105                 110         
His Ala Leu Cys Leu Gln Lys Leu Leu Gln Tyr Asn Cys Pro Thr Glu
        115                 120                 125             
His Ala Asp Leu Gln Gly Arg Thr Ala Leu Gln Lys Lys Ala Met Ala
    130                 135                 140                 
Asp Cys Pro Ser Ser Ile Gln Leu Leu Cys Asp His Gly Ala Ser Val
145                 150                 155                 160 
Asn Ala Lys Asp Val Lys Gly Arg Thr Pro Leu Val Leu Ala Thr Gln
                165                 170                 175     
Met Ser Arg Pro Thr Ile Cys Gln Leu Leu Ile Asp Arg Gly Ala Asp
            180                 185                 190         
Val Asn Ser Arg Asp Lys Gln Asn Arg Thr Ala Leu Met Leu Gly Cys
        195                 200                 205             
Glu Tyr Gly Cys Arg Asp Ala Val Glu Val Leu Ile Lys Asn Gly Ala
    210                 215                 220                 
Asp Ile Ser Leu Leu Asp Ala Leu Gly His Asp Ser Ser Tyr Tyr Ala
225                 230                 235                 240 
Arg Ile Gly Asp Asn Leu Asp Ile Leu Thr Leu Leu Lys Thr Ala Ser
                245                 250                 255     
Glu Asn Thr Asn Lys Gly Arg Glu Leu Trp Lys Lys Gly Pro Ser Leu
            260                 265                 270         
Gln Gln Arg Asn Leu Thr His Met Gln Asp Glu Val Asn Val Lys Ser
        275                 280                 285             
His Gln Arg Glu His Gln Asn Ile Gln Asp Leu Glu Ile Glu Asn Glu
    290                 295                 300                 
Asp Leu Lys Glu Arg Leu Arg Lys Ile Gln Gln Glu Gln Arg Ile Leu
305                 310                 315                 320 
Leu Asp Lys Val Asn Gly Leu Gln Leu Gln Leu Asn Glu Glu Val Met
                325                 330                 335     
Val Ala Asp Asp Leu Glu Ser Glu Arg Glu Lys Leu Lys Ser Leu Leu
            340                 345                 350         
Ala Ala Lys Glu Lys Gln His Glu Glu Ser Leu Arg Thr Ile Glu Ala
        355                 360                 365             
Leu Lys Asn Arg Phe Lys Tyr Phe Glu Ser Asp His Leu Gly Ser Gly
    370                 375                 380                 
Ser His Phe Ser Asn Arg Lys Glu Asp Met Leu Leu Lys Gln Gly Gln
385                 390                 395                 400 
Met Tyr Met Ala Asp Ser Gln Cys Thr Ser Pro Gly Ile Pro Ala His
                405                 410                 415     
Met Gln Ser Arg Ser Met Leu Arg Pro Leu Glu Leu Ser Leu Pro Ser
            420                 425                 430         
Gln Thr Ser Tyr Ser Glu Asn Glu Ile Leu Lys Lys Glu Leu Glu Ala
        435                 440                 445             
Met Arg Thr Phe Cys Glu Ser Ala Lys Gln Asp Arg Leu Lys Leu Gln
    450                 455                 460                 
Asn Glu Leu Ala His Lys Val Ala Glu Cys Lys Ala Leu Ala Leu Glu
465                 470                 475                 480 
Cys Glu Arg Val Lys Glu Asp Ser Asp Glu Gln Ile Lys Gln Leu Glu
                485                 490                 495     
Asp Ala Leu Lys Asp Val Gln Lys Arg Met Tyr Glu Ser Glu Gly Lys
            500                 505                 510         
Val Lys Gln Met Gln Thr His Phe Leu Ala Leu Lys Glu His Leu Thr
        515                 520                 525             
Ser Glu Ala Ala Ser Gly Asn His Arg Leu Thr Glu Glu Leu Lys Asp
    530                 535                 540                 
Gln Leu Lys Asp Leu Lys Val Lys Tyr Glu Gly Ala Ser Ala Glu Val
545                 550                 555                 560 
Gly Lys Leu Arg Asn Gln Ile Lys Gln Asn Glu Met Ile Val Glu Glu
                565                 570                 575     
Phe Lys Arg Asp Glu Gly Lys Leu Ile Glu Glu Asn Lys Arg Leu Gln
            580                 585                 590         
Lys Glu Leu Ser Met Cys Glu Met Glu Arg Glu Lys Lys Gly Arg Lys
        595                 600                 605             
Val Thr Glu Met Glu Gly Gln Ala Lys Glu Leu Ser Ala Lys Leu Ala
    610                 615                 620                 
Leu Ser Ile Pro Ala Glu Lys Phe Glu Asn Met Lys Ser Ser Leu Ser
625                 630                 635                 640 
Asn Glu Val Asn Glu Lys Ala Lys Lys Leu Val Glu Met Glu Arg Glu
                645                 650                 655     
His Glu Lys Ser Leu Ser Glu Ile Arg Gln Leu Lys Arg Glu Leu Glu
            660                 665                 670         
Asn Val Lys Ala Lys Leu Ala Gln His Val Lys Pro Glu Glu His Glu
        675                 680                 685             
Gln Val Lys Ser Arg Leu Glu Gln Lys Ser Gly Glu Leu Gly Lys Lys
    690                 695                 700                 
Ile Thr Glu Leu Thr Leu Lys Asn Gln Thr Leu Gln Lys Glu Ile Glu
705                 710                 715                 720 
Lys Val Tyr Leu Asp Asn Lys Leu Leu Lys Glu Gln Ala His Asn Leu
                725                 730                 735     
Thr Ile Glu Met Lys Asn His Tyr Val Pro Leu Lys Val Ser Glu Asp
            740                 745                 750         
Met Lys Lys Ser His Asp Ala Ile Ile Asp Asp Leu Asn Arg Lys Leu
        755                 760                 765             
Leu Asp Val Thr Gln Lys Tyr Thr Glu Lys Lys Leu Glu Met Glu Lys
    770                 775                 780                 
Leu Leu Leu Glu Asn Asp Ser Leu Ser Lys Asp Val Ser Arg Leu Glu
785                 790                 795                 800 
Thr Val Phe Val Pro Pro Glu Lys His Glu Lys Glu Ile Ile Ala Leu
                805                 810                 815     
Lys Ser Asn Ile Val Glu Leu Lys Lys Gln Leu Ser Glu Leu Lys Lys
            820                 825                 830         
Lys Cys Gly Glu Asp Gln Glu Lys Ile His Ala Leu Thr Ser Glu Asn
        835                 840                 845             
Thr Asn Leu Lys Lys Met Met Ser Asn Gln Tyr Val Pro Val Lys Thr
    850                 855                 860                 
His Glu Glu Val Lys Met Thr Leu Asn Asp Thr Leu Ala Lys Thr Asn
865                 870                 875                 880 
Arg Glu Leu Leu Asp Val Lys Lys Lys Phe Glu Asp Ile Asn Gln Glu
                885                 890                 895     
Phe Val Lys Ile Lys Asp Lys Asn Glu Ile Leu Lys Arg Asn Leu Glu
            900                 905                 910         
Asn Thr Gln Asn Gln Ile Lys Ala Glu Tyr Ile Ser Leu Ala Glu His
        915                 920                 925             
Glu Ala Lys Met Ser Ser Leu Ser Gln Ser Met Arg Lys Val Gln Asp
    930                 935                 940                 
Ser Asn Ala Glu Ile Leu Ala Asn Tyr Arg Lys Gly Gln Glu Glu Ile
945                 950                 955                 960 
Val Thr Leu His Ala Glu Ile Lys Ala Gln Lys Lys Glu Leu Asp Thr
                965                 970                 975     
Ile Gln Glu Cys Ile Lys Val Lys Tyr Ala Pro Ile Val Ser Phe Glu
            980                 985                 990         
Glu Cys Glu Arg Lys Phe Lys Ala Thr Glu Lys Glu Leu Lys Asp Gln
        995                 1000                1005            
Leu Ser Glu Gln Thr Gln Lys Tyr Ser Val Ser Glu Glu Glu Val Lys
    1010                1015                1020                
Lys Asn Lys Gln Glu Asn Asp Lys Leu Lys Lys Glu Ile Phe Thr Leu
1025                1030                1035                1040
Gln Lys Asp Leu Arg Asp Lys Thr Val Leu Ile Glu Lys Ser His Glu
                1045                1050                1055    
Met Glu Arg Ala Leu Ser Arg Lys Thr Asp Glu Leu Asn Lys Gln Leu
            1060                1065                1070        
Lys Asp Leu Ser Gln Lys Tyr Thr Glu Val Lys Asn Val Lys Glu Lys
        1075                1080                1085            
Leu Val Glu Glu Asn Ala Lys Gln Thr Ser Glu Ile Leu Ala Val Gln
    1090                1095                1100                
Asn Leu Leu Gln Lys Gln His Val Pro Leu Glu Gln Val Glu Ala Leu
1105                1110                1115                1120
Lys Lys Ser Leu Asn Gly Thr Ile Glu Asn Leu Lys Glu Glu Leu Lys
                1125                1130                1135    
Ser Met Gln Arg Cys Tyr Glu Lys Glu Gln Gln Thr Val Thr Lys Leu
            1140                1145                1150        
His Gln Leu Leu Glu Asn Gln Lys Asn Ser Ser Val Pro Leu Ala Glu
        1155                1160                1165            
His Leu Gln Ile Lys Glu Ala Phe Glu Lys Glu Val Gly Ile Ile Lys
    1170                1175                1180                
Ala Ser Leu Arg Glu Lys Glu Glu Glu Ser Gln Asn Lys Met Glu Glu
1185                1190                1195                1200
Val Ser Lys Leu Gln Ser Glu Val Gln Asn Thr Lys Gln Ala Leu Lys
                1205                1210                1215    
Lys Leu Glu Thr Arg Glu Val Val Asp Leu Ser Lys Tyr Lys Ala Thr
            1220                1225                1230        
Lys Ser Asp Leu Glu Thr Gln Ile Ser Ser Leu Asn Glu Lys Leu Ala
        1235                1240                1245            
Asn Leu Asn Arg Lys Tyr Glu Glu Val Cys Glu Glu Val Leu His Ala
    1250                1255                1260                
Lys Lys Lys Glu Ile Ser Ala Lys Asp Glu Lys Glu Leu Leu His Phe
1265                1270                1275                1280
Ser Ile Glu Gln Glu Ile Lys Asp Gln Lys Glu Arg Cys Asp Lys Ser
                1285                1290                1295    
Leu Thr Thr Ile Thr Glu Leu Gln Arg Arg Ile Gln Glu Ser Ala Lys
            1300                1305                1310        
Gln Ile Glu Ala Lys Asp Asn Lys Ile Thr Glu Leu Leu Asn Asp Val
        1315                1320                1325            
Glu Arg Leu Lys Gln Ala Leu Asn Gly Leu Ser Gln Leu Thr Tyr Thr
    1330                1335                1340                
Ser Gly Asn Pro Thr Lys Arg Gln Ser Gln Leu Ile Asp Thr Leu Gln
1345                1350                1355                1360
His Gln Val Lys Ser Leu Glu Gln Gln Leu Ala Asp Ala Asp Arg Gln
                1365                1370                1375    
His Gln Glu Val Ile Ala Ile Tyr Arg Thr His Leu Leu Ser Ala Ala
            1380                1385                1390        
Gln Gly His Met Asp Glu Asp Val Gln Glu Ala Leu Leu Gln Ile Ile
        1395                1400                1405            
Gln Met Arg Gln Gly Leu Val Cys
    1410                1415    


<210> 6374
<211> 784
<212> PRT
<213> Homo sapiens

<400> 6374
Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser
 1               5                  10                  15      
Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg
            20                  25                  30          
Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser
        35                  40                  45              
Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile
    50                  55                  60                  
Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala
65                  70                  75                  80  
Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe
                85                  90                  95      
Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu
            100                 105                 110         
Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe
        115                 120                 125             
Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu
    130                 135                 140                 
Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp
145                 150                 155                 160 
Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu
                165                 170                 175     
Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys
            180                 185                 190         
Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys
        195                 200                 205             
Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val
    210                 215                 220                 
Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser
225                 230                 235                 240 
Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe
                245                 250                 255     
Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu
            260                 265                 270         
Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr
        275                 280                 285             
Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile
    290                 295                 300                 
Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro
305                 310                 315                 320 
Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu
                325                 330                 335     
Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro
            340                 345                 350         
Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser
        355                 360                 365             
Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp
    370                 375                 380                 
Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala
385                 390                 395                 400 
Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr
                405                 410                 415     
Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys
            420                 425                 430         
Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile
        435                 440                 445             
His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val
    450                 455                 460                 
Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys
465                 470                 475                 480 
Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser
                485                 490                 495     
Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr
            500                 505                 510         
Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu
        515                 520                 525             
Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe
    530                 535                 540                 
Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala
545                 550                 555                 560 
Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln
                565                 570                 575     
Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser
            580                 585                 590         
Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu
        595                 600                 605             
Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp
    610                 615                 620                 
Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys
625                 630                 635                 640 
Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu
                645                 650                 655     
Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu
            660                 665                 670         
Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn
        675                 680                 685             
Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser
    690                 695                 700                 
Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser
705                 710                 715                 720 
His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu
                725                 730                 735     
Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu
            740                 745                 750         
Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu
        755                 760                 765             
Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser
    770                 775                 780                 


<210> 6375
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6375
Met Ser Leu Leu Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu
 1               5                  10                  15      
Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu
            20                  25                  30          
Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln
        35                  40                  45              
Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly
    50                  55                  60                  
Met Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His His Asp Gly Val
65                  70                  75                  80  
Ser Lys Ala Asn Phe Ser Ile Ser Arg Met Thr Gln Asp Leu Ala Gly
                85                  90                  95      
Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Val Ser
            100                 105                 110         
Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys
        115                 120                 125             
Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Asn
    130                 135                 140                 
Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu
145                 150                 155                 160 
Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Gly Pro Lys
                165                 170                 175     
Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His
            180                 185                 190         
Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu
        195                 200                 205             
Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro
    210                 215                 220                 
Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn
225                 230                 235                 240 
Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu
                245                 250                 255     
Phe Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys
            260                 265                 270         
Asn Ala Ala Val Met Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn
        275                 280                 285             
Ser Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln
    290                 295                 300                 
Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln
305                 310                 315                 320 
Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro
                325                 330                 335     
Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro
            340                 345             


<210> 6376
<211> 304
<212> PRT
<213> Homo sapiens

<400> 6376
Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu
 1               5                  10                  15      
Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu
            20                  25                  30          
Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln
        35                  40                  45              
Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly
    50                  55                  60                  
Met Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His His Asp Gly Val
65                  70                  75                  80  
Ser Lys Ala Asn Phe Ser Ile Ser Arg Met Arg Gln Asp Leu Ala Gly
                85                  90                  95      
Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser
            100                 105                 110         
Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys
        115                 120                 125             
Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Asn
    130                 135                 140                 
Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu
145                 150                 155                 160 
Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Gly Thr Lys
                165                 170                 175     
Val Asn Gly Thr Phe Gln Ala Asn Phe Pro Leu Gly Pro Ala Thr His
            180                 185                 190         
Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu
        195                 200                 205             
Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro
    210                 215                 220                 
Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn
225                 230                 235                 240 
Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro
                245                 250                 255     
Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys
            260                 265                 270         
Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val
        275                 280                 285             
Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala
    290                 295                 300                 


<210> 6377
<211> 1066
<212> PRT
<213> Homo sapiens

<400> 6377
Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu
 1               5                  10                  15      
Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser
            20                  25                  30          
Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala
        35                  40                  45              
Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu
    50                  55                  60                  
Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg
65                  70                  75                  80  
Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser
                85                  90                  95      
Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr
            100                 105                 110         
Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu
        115                 120                 125             
Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys
    130                 135                 140                 
Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu
145                 150                 155                 160 
Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met
                165                 170                 175     
Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly
            180                 185                 190         
His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln
        195                 200                 205             
Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln
    210                 215                 220                 
Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala
225                 230                 235                 240 
Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln
                245                 250                 255     
Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly
            260                 265                 270         
Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro
        275                 280                 285             
Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr
    290                 295                 300                 
Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn
305                 310                 315                 320 
Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala
                325                 330                 335     
Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu
            340                 345                 350         
Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val
        355                 360                 365             
Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro
    370                 375                 380                 
Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile
385                 390                 395                 400 
Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr
                405                 410                 415     
Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met
            420                 425                 430         
Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr
        435                 440                 445             
Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp
    450                 455                 460                 
Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val
465                 470                 475                 480 
Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln
                485                 490                 495     
Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn
            500                 505                 510         
Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro
        515                 520                 525             
Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg
    530                 535                 540                 
Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp
545                 550                 555                 560 
Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser
                565                 570                 575     
Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys
            580                 585                 590         
Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr
        595                 600                 605             
Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro
    610                 615                 620                 
Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala
625                 630                 635                 640 
Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser
                645                 650                 655     
Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro
            660                 665                 670         
Gly Val Trp His Asp His Pro Lys Tyr Pro Gly Ser Val Asn Ser Ala
        675                 680                 685             
Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala
    690                 695                 700                 
Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr
705                 710                 715                 720 
Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly
                725                 730                 735     
Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn
            740                 745                 750         
Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg
        755                 760                 765             
Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser
    770                 775                 780                 
Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg
785                 790                 795                 800 
Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val
                805                 810                 815     
Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg Phe Arg
            820                 825                 830         
Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro
        835                 840                 845             
Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala
    850                 855                 860                 
Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro
865                 870                 875                 880 
Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr
                885                 890                 895     
Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val
            900                 905                 910         
Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Tyr Thr Asn Asn Gln
        915                 920                 925             
Ala Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Ile
    930                 935                 940                 
Ala Leu Leu Val Leu Ile Leu Leu Ile Val Cys Phe Ile Lys Arg Ser
945                 950                 955                 960 
Arg Gly Gly Lys Tyr Pro Val Arg Glu Lys Lys Asp Val Pro Leu Gly
                965                 970                 975     
Pro Glu Asp Pro Lys Glu Glu Asp Gly Ser Phe Asp Tyr Ser Asp Glu
            980                 985                 990         
Asp Asn Lys Pro Leu Gln Gly Ser Gln Thr Ser Leu Asp Gly Thr Ile
        995                 1000                1005            
Lys Gln Gln Glu Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Gly
    1010                1015                1020                
Glu Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Thr Val
1025                1030                1035                1040
Lys Lys Asp Lys Glu Glu Thr Glu Gly Asn Glu Ser Ser Glu Ala Thr
                1045                1050                1055    
Ser Pro Val Asn Ala Ile Tyr Ser Leu Ala
            1060                1065    


<210> 6378
<211> 1240
<212> PRT
<213> Homo sapiens

<400> 6378
Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu
 1               5                  10                  15      
Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser
            20                  25                  30          
Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala
        35                  40                  45              
Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu
    50                  55                  60                  
Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg
65                  70                  75                  80  
Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser
                85                  90                  95      
Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr
            100                 105                 110         
Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu
        115                 120                 125             
Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys
    130                 135                 140                 
Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu
145                 150                 155                 160 
Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met
                165                 170                 175     
Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly
            180                 185                 190         
His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln
        195                 200                 205             
Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln
    210                 215                 220                 
Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala
225                 230                 235                 240 
Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln
                245                 250                 255     
Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly
            260                 265                 270         
Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro
        275                 280                 285             
Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr
    290                 295                 300                 
Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn
305                 310                 315                 320 
Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala
                325                 330                 335     
Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu
            340                 345                 350         
Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val
        355                 360                 365             
Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro
    370                 375                 380                 
Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile
385                 390                 395                 400 
Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr
                405                 410                 415     
Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met
            420                 425                 430         
Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr
        435                 440                 445             
Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp
    450                 455                 460                 
Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val
465                 470                 475                 480 
Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln
                485                 490                 495     
Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn
            500                 505                 510         
Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro
        515                 520                 525             
Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg
    530                 535                 540                 
Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp
545                 550                 555                 560 
Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser
                565                 570                 575     
Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys
            580                 585                 590         
Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr
        595                 600                 605             
Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro
    610                 615                 620                 
Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala
625                 630                 635                 640 
Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser
                645                 650                 655     
Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro
            660                 665                 670         
Gly Val Trp His Asp His Pro Lys Tyr Pro Gly Ser Val Asn Ser Ala
        675                 680                 685             
Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala
    690                 695                 700                 
Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr
705                 710                 715                 720 
Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly
                725                 730                 735     
Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn
            740                 745                 750         
Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg
        755                 760                 765             
Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser
    770                 775                 780                 
Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg
785                 790                 795                 800 
Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val
                805                 810                 815     
Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg Phe Arg
            820                 825                 830         
Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro
        835                 840                 845             
Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala
    850                 855                 860                 
Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro
865                 870                 875                 880 
Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr
                885                 890                 895     
Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val
            900                 905                 910         
Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Thr Pro Thr Ala Ala
        915                 920                 925             
Pro Pro Thr Leu Pro Pro Thr Thr Val Gly Ala Thr Gly Ala Val Ser
    930                 935                 940                 
Ser Thr Asp Ala Thr Ala Ile Ala Ala Thr Thr Glu Ala Thr Thr Val
945                 950                 955                 960 
Pro Ile Ile Pro Thr Val Ala Pro Thr Thr Ile Ala Thr Thr Thr Thr
                965                 970                 975     
Val Ala Thr Thr Thr Thr Thr Thr Ala Ala Ala Thr Thr Thr Thr Glu
            980                 985                 990         
Ser Pro Pro Thr Thr Thr Ser Gly Thr Lys Ile His Glu Ser Ala Pro
        995                 1000                1005            
Asp Glu Gln Ser Ile Trp Asn Val Thr Val Leu Pro Asn Ser Lys Trp
    1010                1015                1020                
Ala Asn Ile Thr Trp Lys His Asn Phe Gly Pro Gly Thr Asp Phe Val
1025                1030                1035                1040
Val Glu Tyr Ile Asp Ser Asn His Thr Lys Lys Thr Val Pro Val Lys
                1045                1050                1055    
Ala Gln Ala Gln Pro Ile Gln Leu Thr Asp Leu Tyr Pro Gly Met Thr
            1060                1065                1070        
Tyr Thr Leu Arg Val Tyr Ser Arg Asp Asn Glu Gly Ile Ser Ser Thr
        1075                1080                1085            
Val Ile Thr Phe Met Thr Ser Thr Ala Tyr Thr Asn Asn Gln Ala Asp
    1090                1095                1100                
Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Ile Ala Leu
1105                1110                1115                1120
Leu Val Leu Ile Leu Leu Ile Val Cys Phe Ile Lys Arg Ser Arg Gly
                1125                1130                1135    
Gly Lys Tyr Pro Val Arg Glu Lys Lys Asp Val Pro Leu Gly Pro Glu
            1140                1145                1150        
Asp Pro Lys Glu Glu Asp Gly Ser Phe Asp Tyr Ser Asp Glu Asp Asn
        1155                1160                1165            
Lys Pro Leu Gln Gly Ser Gln Thr Ser Leu Asp Gly Thr Ile Lys Gln
    1170                1175                1180                
Gln Glu Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Gly Glu Gly
1185                1190                1195                1200
Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Thr Val Lys Lys
                1205                1210                1215    
Asp Lys Glu Glu Thr Glu Gly Asn Glu Ser Ser Glu Ala Thr Ser Pro
            1220                1225                1230        
Val Asn Ala Ile Tyr Ser Leu Ala
        1235                1240


<210> 6379
<211> 1071
<212> PRT
<213> Homo sapiens

<400> 6379
Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu
 1               5                  10                  15      
Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser
            20                  25                  30          
Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala
        35                  40                  45              
Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu
    50                  55                  60                  
Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg
65                  70                  75                  80  
Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser
                85                  90                  95      
Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr
            100                 105                 110         
Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu
        115                 120                 125             
Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys
    130                 135                 140                 
Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu
145                 150                 155                 160 
Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met
                165                 170                 175     
Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly
            180                 185                 190         
His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln
        195                 200                 205             
Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln
    210                 215                 220                 
Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala
225                 230                 235                 240 
Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln
                245                 250                 255     
Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly
            260                 265                 270         
Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro
        275                 280                 285             
Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr
    290                 295                 300                 
Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn
305                 310                 315                 320 
Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala
                325                 330                 335     
Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu
            340                 345                 350         
Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val
        355                 360                 365             
Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro
    370                 375                 380                 
Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile
385                 390                 395                 400 
Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr
                405                 410                 415     
Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met
            420                 425                 430         
Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr
        435                 440                 445             
Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp
    450                 455                 460                 
Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val
465                 470                 475                 480 
Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln
                485                 490                 495     
Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn
            500                 505                 510         
Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro
        515                 520                 525             
Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg
    530                 535                 540                 
Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp
545                 550                 555                 560 
Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser
                565                 570                 575     
Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys
            580                 585                 590         
Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr
        595                 600                 605             
Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro
    610                 615                 620                 
Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala
625                 630                 635                 640 
Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser
                645                 650                 655     
Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro
            660                 665                 670         
Gly Val Trp His Asp His Pro Lys Tyr Pro Gly Ser Val Asn Ser Ala
        675                 680                 685             
Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala
    690                 695                 700                 
Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr
705                 710                 715                 720 
Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly
                725                 730                 735     
Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn
            740                 745                 750         
Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg
        755                 760                 765             
Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser
    770                 775                 780                 
Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg
785                 790                 795                 800 
Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val
                805                 810                 815     
Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg Phe Arg
            820                 825                 830         
Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro
        835                 840                 845             
Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala
    850                 855                 860                 
Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro
865                 870                 875                 880 
Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr
                885                 890                 895     
Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val
            900                 905                 910         
Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Thr Pro Thr Ala Ala
        915                 920                 925             
Tyr Thr Asn Asn Gln Ala Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly
    930                 935                 940                 
Leu Met Cys Ala Ile Ala Leu Leu Val Leu Ile Leu Leu Ile Val Cys
945                 950                 955                 960 
Phe Ile Lys Arg Ser Arg Gly Gly Lys Tyr Pro Val Arg Glu Lys Lys
                965                 970                 975     
Asp Val Pro Leu Gly Pro Glu Asp Pro Lys Glu Glu Asp Gly Ser Phe
            980                 985                 990         
Asp Tyr Ser Asp Glu Asp Asn Lys Pro Leu Gln Gly Ser Gln Thr Ser
        995                 1000                1005            
Leu Asp Gly Thr Ile Lys Gln Gln Glu Ser Asp Asp Ser Leu Val Asp
    1010                1015                1020                
Tyr Gly Glu Gly Gly Glu Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile
1025                1030                1035                1040
Gly Gln Tyr Thr Val Lys Lys Asp Lys Glu Glu Thr Glu Gly Asn Glu
                1045                1050                1055    
Ser Ser Glu Ala Thr Ser Pro Val Asn Ala Ile Tyr Ser Leu Ala
            1060                1065                1070    


<210> 6380
<211> 796
<212> PRT
<213> Homo sapiens

<400> 6380
Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala
 1               5                  10                  15      
Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly
            20                  25                  30          
Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu
        35                  40                  45              
Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly
    50                  55                  60                  
Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln
65                  70                  75                  80  
His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu
                85                  90                  95      
Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His
            100                 105                 110         
Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu
        115                 120                 125             
Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val
    130                 135                 140                 
Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln
145                 150                 155                 160 
Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln
                165                 170                 175     
Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly
            180                 185                 190         
Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly
        195                 200                 205             
Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln
    210                 215                 220                 
Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys
225                 230                 235                 240 
Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser
                245                 250                 255     
Asp Leu Asn Arg Lys Asn Leu Thr Cys Trp Ala Glu Asn Asp Val Gly
            260                 265                 270         
Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val
        275                 280                 285             
Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser
    290                 295                 300                 
Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser
305                 310                 315                 320 
Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala
                325                 330                 335     
Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr
            340                 345                 350         
His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly
        355                 360                 365             
Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu
    370                 375                 380                 
Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr
385                 390                 395                 400 
Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe
                405                 410                 415     
Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu
            420                 425                 430         
Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe
        435                 440                 445             
Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met
    450                 455                 460                 
Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu
465                 470                 475                 480 
Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr
                485                 490                 495     
Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu
            500                 505                 510         
Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu
        515                 520                 525             
Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys
    530                 535                 540                 
Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu
545                 550                 555                 560 
Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe
                565                 570                 575     
Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met
            580                 585                 590         
Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala
        595                 600                 605             
Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu
    610                 615                 620                 
Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr
625                 630                 635                 640 
Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys
                645                 650                 655     
Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser
            660                 665                 670         
Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met
        675                 680                 685             
Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe
    690                 695                 700                 
Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile
705                 710                 715                 720 
Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala
                725                 730                 735     
Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys
            740                 745                 750         
Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro
        755                 760                 765             
Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu
    770                 775                 780                 
Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly
785                 790                 795     


<210> 6381
<211> 882
<212> PRT
<213> Homo sapiens

<400> 6381
Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln
 1               5                  10                  15      
Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe
            20                  25                  30          
Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg
        35                  40                  45              
Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln
    50                  55                  60                  
Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp
65                  70                  75                  80  
Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile
                85                  90                  95      
His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr
            100                 105                 110         
Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His
        115                 120                 125             
Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn
    130                 135                 140                 
Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro
145                 150                 155                 160 
Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val
                165                 170                 175     
Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile
            180                 185                 190         
Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu
        195                 200                 205             
Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg
    210                 215                 220                 
Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn
225                 230                 235                 240 
Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn
                245                 250                 255     
Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met
            260                 265                 270         
Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp
        275                 280                 285             
Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile
    290                 295                 300                 
Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn
305                 310                 315                 320 
Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu
                325                 330                 335     
Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly
            340                 345                 350         
Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr
        355                 360                 365             
Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val
    370                 375                 380                 
Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp
385                 390                 395                 400 
Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu
                405                 410                 415     
Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn
            420                 425                 430         
Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln
        435                 440                 445             
Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val
    450                 455                 460                 
Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val
465                 470                 475                 480 
Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser
                485                 490                 495     
Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu
            500                 505                 510         
Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp
        515                 520                 525             
Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr
    530                 535                 540                 
Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr
545                 550                 555                 560 
Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr
                565                 570                 575     
Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala
            580                 585                 590         
Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys
        595                 600                 605             
Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser
    610                 615                 620                 
Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile
625                 630                 635                 640 
Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met
                645                 650                 655     
Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn
            660                 665                 670         
Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys
        675                 680                 685             
Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly
    690                 695                 700                 
Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu
705                 710                 715                 720 
Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val
                725                 730                 735     
Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val
            740                 745                 750         
Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp
        755                 760                 765             
Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg
    770                 775                 780                 
Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg
785                 790                 795                 800 
Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys
                805                 810                 815     
Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val
            820                 825                 830         
Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu
        835                 840                 845             
Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu
    850                 855                 860                 
Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu
865                 870                 875                 880 
Asp Asp
        


<210> 6382
<211> 821
<212> PRT
<213> Homo sapiens

<400> 6382
Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln
 1               5                  10                  15      
Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe
            20                  25                  30          
Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg
        35                  40                  45              
Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln
    50                  55                  60                  
Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp
65                  70                  75                  80  
Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile
                85                  90                  95      
His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr
            100                 105                 110         
Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His
        115                 120                 125             
Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn
    130                 135                 140                 
Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro
145                 150                 155                 160 
Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val
                165                 170                 175     
Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile
            180                 185                 190         
Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu
        195                 200                 205             
Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg
    210                 215                 220                 
Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn
225                 230                 235                 240 
Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn
                245                 250                 255     
Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met
            260                 265                 270         
Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp
        275                 280                 285             
Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile
    290                 295                 300                 
Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn
305                 310                 315                 320 
Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu
                325                 330                 335     
Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly
            340                 345                 350         
Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr
        355                 360                 365             
Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Gly Leu Asp Phe Glu
    370                 375                 380                 
Ala Lys Gln Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro
385                 390                 395                 400 
Phe Glu Val Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val
                405                 410                 415     
Leu Asp Val Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val
            420                 425                 430         
Glu Val Ser Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr
        435                 440                 445             
Ala Gln Glu Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile
    450                 455                 460                 
Trp Arg Asp Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala
465                 470                 475                 480 
Ile Ser Thr Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys
                485                 490                 495     
Asn Ser Thr Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro
            500                 505                 510         
Val Ala Thr Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn
        515                 520                 525             
Asp Asn Ala Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg
    530                 535                 540                 
Asn Pro Lys Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro
545                 550                 555                 560 
Asn Thr Ser Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn
                565                 570                 575     
Trp Thr Ile Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys
            580                 585                 590         
Pro Lys Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu
        595                 600                 605             
Met Asp Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val
    610                 615                 620                 
Cys Asp Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val
625                 630                 635                 640 
Glu Ala Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile
                645                 650                 655     
Leu Ala Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg
            660                 665                 670         
Arg Ala Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg
        675                 680                 685             
Asp Asn Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln
    690                 695                 700                 
Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu
705                 710                 715                 720 
Val Thr Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr
                725                 730                 735     
Leu Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu
            740                 745                 750         
Asn Leu Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser
        755                 760                 765             
Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu
    770                 775                 780                 
Ser Ser Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr
785                 790                 795                 800 
Leu Asn Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly
                805                 810                 815     
Gly Gly Glu Asp Asp
            820     


<210> 6383
<211> 961
<212> PRT
<213> Homo sapiens

<400> 6383
Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu
 1               5                  10                  15      
Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp
            20                  25                  30          
Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro
        35                  40                  45              
Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe
    50                  55                  60                  
Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser
65                  70                  75                  80  
Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Ser
                85                  90                  95      
Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val
            100                 105                 110         
Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu
        115                 120                 125             
Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr
    130                 135                 140                 
Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe
145                 150                 155                 160 
Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln
                165                 170                 175     
Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly
            180                 185                 190         
Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser
        195                 200                 205             
Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu
    210                 215                 220                 
Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu
225                 230                 235                 240 
Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala
                245                 250                 255     
Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser
            260                 265                 270         
Thr Val Val Ala Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg
        275                 280                 285             
Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser
    290                 295                 300                 
Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn
305                 310                 315                 320 
Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr
                325                 330                 335     
Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala
            340                 345                 350         
Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser
        355                 360                 365             
Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg
    370                 375                 380                 
Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser
385                 390                 395                 400 
Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg
                405                 410                 415     
Gly Cys Lys Val Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys
            420                 425                 430         
Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys
        435                 440                 445             
Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp
    450                 455                 460                 
Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg
465                 470                 475                 480 
Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu
                485                 490                 495     
Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp
            500                 505                 510         
Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn
        515                 520                 525             
Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp
    530                 535                 540                 
Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp
545                 550                 555                 560 
Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys
                565                 570                 575     
Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp
            580                 585                 590         
Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val
        595                 600                 605             
Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser
    610                 615                 620                 
Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr
625                 630                 635                 640 
Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys
                645                 650                 655     
Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile
            660                 665                 670         
Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn
        675                 680                 685             
Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu
    690                 695                 700                 
Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro
705                 710                 715                 720 
Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val
                725                 730                 735     
Gly Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val
            740                 745                 750         
Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly
        755                 760                 765             
Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr
    770                 775                 780                 
Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe
785                 790                 795                 800 
Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr
                805                 810                 815     
Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro
            820                 825                 830         
Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His
        835                 840                 845             
Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg
    850                 855                 860                 
Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser
865                 870                 875                 880 
Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val
                885                 890                 895     
Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile
            900                 905                 910         
Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln
        915                 920                 925             
Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile
    930                 935                 940                 
Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp
945                 950                 955                 960 
Asn
    


<210> 6384
<211> 961
<212> PRT
<213> Homo sapiens

<400> 6384
Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu
 1               5                  10                  15      
Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp
            20                  25                  30          
Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro
        35                  40                  45              
Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe
    50                  55                  60                  
Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser
65                  70                  75                  80  
Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Asn
                85                  90                  95      
Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val
            100                 105                 110         
Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu
        115                 120                 125             
Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr
    130                 135                 140                 
Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe
145                 150                 155                 160 
Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln
                165                 170                 175     
Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly
            180                 185                 190         
Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser
        195                 200                 205             
Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu
    210                 215                 220                 
Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu
225                 230                 235                 240 
Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala
                245                 250                 255     
Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser
            260                 265                 270         
Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg
        275                 280                 285             
Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser
    290                 295                 300                 
Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn
305                 310                 315                 320 
Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr
                325                 330                 335     
Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala
            340                 345                 350         
Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser
        355                 360                 365             
Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg
    370                 375                 380                 
Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser
385                 390                 395                 400 
Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg
                405                 410                 415     
Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys
            420                 425                 430         
Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys
        435                 440                 445             
Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp
    450                 455                 460                 
Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg
465                 470                 475                 480 
Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu
                485                 490                 495     
Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp
            500                 505                 510         
Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn
        515                 520                 525             
Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp
    530                 535                 540                 
Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp
545                 550                 555                 560 
Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys
                565                 570                 575     
Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp
            580                 585                 590         
Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val
        595                 600                 605             
Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser
    610                 615                 620                 
Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr
625                 630                 635                 640 
Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys
                645                 650                 655     
Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile
            660                 665                 670         
Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn
        675                 680                 685             
Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu
    690                 695                 700                 
Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro
705                 710                 715                 720 
Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val
                725                 730                 735     
Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val
            740                 745                 750         
Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly
        755                 760                 765             
Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr
    770                 775                 780                 
Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe
785                 790                 795                 800 
Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr
                805                 810                 815     
Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro
            820                 825                 830         
Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His
        835                 840                 845             
Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg
    850                 855                 860                 
Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser
865                 870                 875                 880 
Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val
                885                 890                 895     
Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile
            900                 905                 910         
Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln
        915                 920                 925             
Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile
    930                 935                 940                 
Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp
945                 950                 955                 960 
Asn
    


<210> 6385
<211> 626
<212> PRT
<213> Homo sapiens

<400> 6385
Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Pro
 1               5                  10                  15      
His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn
            20                  25                  30          
Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp
        35                  40                  45              
Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu
    50                  55                  60                  
Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg
65                  70                  75                  80  
Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly
                85                  90                  95      
Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly
            100                 105                 110         
Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu
        115                 120                 125             
Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu
    130                 135                 140                 
Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu
145                 150                 155                 160 
Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu
                165                 170                 175     
Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr
            180                 185                 190         
Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe
        195                 200                 205             
Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu
    210                 215                 220                 
Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala
225                 230                 235                 240 
Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr
                245                 250                 255     
Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val
            260                 265                 270         
Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp
        275                 280                 285             
Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys
    290                 295                 300                 
Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala His Thr
305                 310                 315                 320 
Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu Asp Ser
                325                 330                 335     
Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys Glu Gln
            340                 345                 350         
Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His Met Glu
        355                 360                 365             
Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro Thr Pro
    370                 375                 380                 
Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn Met Thr
385                 390                 395                 400 
Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu
                405                 410                 415     
Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile
            420                 425                 430         
Ala Thr Ser Pro Thr Ile Leu Val Ser Ala Thr Ser Leu Ile Thr Pro
        435                 440                 445             
Lys Ser Thr Phe Leu Thr Thr Thr Lys Pro Val Ser Leu Leu Glu Ser
    450                 455                 460                 
Thr Lys Lys Thr Ile Pro Glu Leu Asp Gln Pro Pro Lys Leu Arg Gly
465                 470                 475                 480 
Val Leu Gln Gly His Leu Glu Ser Ser Arg Asn Asp Pro Phe Leu His
                485                 490                 495     
Pro Asp Phe Cys Cys Leu Leu Pro Leu Gly Phe Tyr Val Leu Gly Leu
            500                 505                 510         
Phe Trp Leu Leu Phe Ala Ser Val Val Leu Ile Leu Leu Leu Ser Trp
        515                 520                 525             
Val Gly His Val Lys Pro Gln Ala Leu Asp Ser Gly Gln Gly Ala Ala
    530                 535                 540                 
Leu Thr Thr Ala Thr Gln Thr Thr His Leu Glu Leu Gln Arg Gly Arg
545                 550                 555                 560 
Gln Val Thr Val Pro Arg Ala Trp Leu Leu Phe Leu Arg Gly Ser Leu
                565                 570                 575     
Pro Thr Phe Arg Ser Ser Leu Phe Leu Trp Val Arg Pro Asn Gly Arg
            580                 585                 590         
Val Gly Pro Leu Val Ala Gly Arg Arg Pro Ser Ala Leu Ser Gln Gly
        595                 600                 605             
Arg Gly Gln Asp Leu Leu Ser Thr Val Ser Ile Arg Tyr Ser Gly His
    610                 615                 620                 
Ser Leu
625     


<210> 6386
<211> 1052
<212> PRT
<213> Homo sapiens

<400> 6386
Ile Leu Ile Thr Arg Arg Ser Ala Gln Gly Pro Ala Pro Ser Leu Gln
 1               5                  10                  15      
Cys Pro Pro Leu Ser Ala Ala Arg Arg Ser Leu Leu Ala Leu Gly Leu
            20                  25                  30          
Ala Met Gly Lys Lys Ser Arg Ala Val Pro Gly Arg Arg Pro Ile Leu
        35                  40                  45              
Gln Leu Ser Pro Pro Gly Pro Arg Gly Ser Thr Pro Gly Arg Asp Pro
    50                  55                  60                  
Glu Pro Glu Pro Asp Thr Glu Pro Asp Ser Thr Ala Ala Val Pro Ser
65                  70                  75                  80  
Gln Pro Ala Pro Ser Ala Ala Thr Thr Thr Thr Thr Ala Val Thr Ala
                85                  90                  95      
Ala Ala Ala Ser Asp Asp Ser Pro Ser Glu Gly Lys Asp Glu Gln Glu
            100                 105                 110         
Ala Val Gln Glu Val Pro Arg Val Val Gln Asn Pro Pro Lys Pro Val
        115                 120                 125             
Met Thr Thr Arg Pro Thr Ala Val Lys Ala Thr Gly Gly Leu Cys Leu
    130                 135                 140                 
Leu Gly Ala Tyr Ala Asp Ser Asp Asp Asp Asp Asn Asp Val Ser Glu
145                 150                 155                 160 
Lys Leu Ala Gln Ser Lys Glu Thr Asn Gly Asn Gln Ser Thr Asp Ile
                165                 170                 175     
Asp Ser Thr Leu Ala Asn Phe Leu Ala Glu Ile Asp Ala Ile Thr Ala
            180                 185                 190         
Pro Gln Pro Ala Ala Pro Val Gly Ala Ser Ala Pro Pro Pro Thr Pro
        195                 200                 205             
Pro Arg Pro Glu Pro Lys Glu Ala Ala Thr Ser Thr Leu Ser Ser Ser
    210                 215                 220                 
Thr Ser Asn Gly Thr Asp Ser Thr Gln Thr Ser Gly Trp Gln Tyr Asp
225                 230                 235                 240 
Thr Gln Cys Ser Leu Ala Gly Val Gly Ile Glu Met Gly Asp Trp Gln
                245                 250                 255     
Glu Val Trp Asp Glu Asn Thr Gly Cys Tyr Tyr Tyr Trp Asn Thr Gln
            260                 265                 270         
Thr Asn Glu Val Thr Trp Glu Leu Pro Gln Tyr Leu Ala Thr Gln Val
        275                 280                 285             
Gln Gly Leu Gln His Tyr Gln Pro Ser Ser Val Pro Gly Ala Glu Thr
    290                 295                 300                 
Ser Phe Val Val Asn Thr Asp Ile Tyr Ser Lys Glu Lys Thr Ile Ser
305                 310                 315                 320 
Val Ser Ser Ser Lys Ser Gly Pro Val Ile Ala Lys Arg Glu Val Lys
                325                 330                 335     
Lys Glu Val Asn Glu Gly Ile Gln Ala Leu Ser Asn Ser Glu Glu Glu
            340                 345                 350         
Lys Lys Gly Val Ala Ala Ser Leu Leu Ala Pro Leu Leu Pro Glu Gly
        355                 360                 365             
Ile Lys Glu Glu Glu Glu Arg Trp Arg Arg Lys Val Ile Cys Lys Glu
    370                 375                 380                 
Glu Pro Val Ser Glu Val Lys Glu Thr Ser Thr Thr Val Glu Glu Ala
385                 390                 395                 400 
Thr Thr Ile Val Lys Pro Gln Glu Ile Met Leu Asp Asn Ile Glu Asp
                405                 410                 415     
Pro Ser Gln Glu Asp Leu Cys Ser Val Val Gln Ser Gly Glu Ser Glu
            420                 425                 430         
Glu Glu Glu Glu Gln Asp Thr Leu Glu Leu Glu Leu Val Leu Glu Arg
        435                 440                 445             
Lys Lys Ala Glu Leu Arg Ala Leu Glu Glu Gly Asp Gly Ser Val Ser
    450                 455                 460                 
Gly Ser Ser Pro Arg Ser Asp Ile Ser Gln Pro Ala Ser Gln Asp Gly
465                 470                 475                 480 
Met Arg Arg Leu Met Ser Lys Arg Gly Lys Trp Lys Met Phe Val Arg
                485                 490                 495     
Ala Thr Ser Pro Glu Ser Thr Ser Arg Ser Ser Ser Lys Thr Gly Arg
            500                 505                 510         
Asp Thr Pro Glu Asn Gly Glu Thr Ala Ile Gly Ala Glu Asn Ser Glu
        515                 520                 525             
Lys Ile Asp Glu Asn Ser Asp Lys Glu Met Glu Val Glu Glu Ser Pro
    530                 535                 540                 
Glu Lys Ile Lys Val Gln Thr Thr Pro Lys Val Glu Glu Glu Gln Asp
545                 550                 555                 560 
Leu Lys Phe Gln Ile Gly Glu Leu Ala Asn Thr Leu Thr Ser Lys Phe
                565                 570                 575     
Glu Phe Leu Gly Ile Asn Arg Gln Ser Ile Ser Asn Phe His Val Leu
            580                 585                 590         
Leu Leu Gln Thr Glu Thr Arg Ile Ala Asp Trp Arg Glu Gly Ala Leu
        595                 600                 605             
Asn Gly Asn Tyr Leu Lys Arg Lys Leu Gln Asp Ala Ala Glu Gln Leu
    610                 615                 620                 
Lys Gln Tyr Glu Ile Asn Ala Thr Pro Lys Gly Trp Ser Cys His Trp
625                 630                 635                 640 
Asp Arg Asp His Arg Arg Tyr Phe Tyr Val Asn Glu Gln Ser Gly Glu
                645                 650                 655     
Ser Gln Trp Glu Phe Pro Asp Gly Glu Glu Glu Glu Glu Glu Ser Gln
            660                 665                 670         
Ala Gln Glu Asn Arg Asp Glu Thr Leu Ala Lys Gln Thr Leu Lys Asp
        675                 680                 685             
Lys Thr Gly Thr Asp Ser Asn Ser Thr Glu Ser Ser Glu Thr Ser Thr
    690                 695                 700                 
Gly Ser Leu Cys Lys Glu Ser Phe Ser Gly Gln Val Ser Ser Ser Ser
705                 710                 715                 720 
Leu Met Pro Leu Thr Pro Phe Trp Thr Leu Leu Gln Ser Asn Val Pro
                725                 730                 735     
Val Leu Gln Pro Pro Leu Pro Leu Glu Met Pro Pro Pro Pro Pro Pro
            740                 745                 750         
Pro Pro Glu Ser Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu
        755                 760                 765             
Asp Gly Glu Ile Gln Glu Val Glu Met Glu Asp Glu Gly Ser Glu Glu
    770                 775                 780                 
Pro Pro Ala Pro Gly Thr Glu Glu Asp Thr Pro Leu Lys Pro Ser Ala
785                 790                 795                 800 
Gln Thr Thr Val Val Thr Ser Gln Ser Ser Val Asp Ser Thr Ile Ser
                805                 810                 815     
Ser Ser Ser Ser Thr Lys Gly Ile Lys Arg Lys Ala Thr Glu Ile Ser
            820                 825                 830         
Thr Ala Val Val Gln Arg Ser Ala Thr Ile Gly Ser Ser Pro Val Leu
        835                 840                 845             
Tyr Ser Gln Ser Ala Ile Ala Thr Gly His Gln Ala Ala Gly Ile Gly
    850                 855                 860                 
Asn Gln Ala Thr Gly Ile Gly His Gln Thr Ile Pro Val Ser Leu Pro
865                 870                 875                 880 
Ala Ala Gly Met Gly His Gln Ala Arg Gly Met Ser Leu Gln Ser Asn
                885                 890                 895     
Tyr Leu Gly Leu Ala Ala Ala Pro Ala Ile Met Ser Tyr Ala Glu Cys
            900                 905                 910         
Ser Val Pro Ile Gly Val Thr Ala Pro Ser Leu Gln Pro Val Gln Ala
        915                 920                 925             
Arg Gly Ala Val Pro Thr Ala Thr Ile Ile Glu Pro Pro Pro Pro Pro
    930                 935                 940                 
Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Lys Met Pro Pro Pro
945                 950                 955                 960 
Glu Lys Thr Lys Lys Gly Arg Lys Asp Lys Ala Lys Lys Ser Lys Thr
                965                 970                 975     
Lys Met Pro Ser Leu Val Lys Lys Trp Gln Ser Ile Gln Arg Glu Leu
            980                 985                 990         
Asp Glu Glu Asp Asn Ser Ser Ser Ser Glu Glu Asp Arg Glu Ser Thr
        995                 1000                1005            
Ala Gln Lys Arg Ile Glu Glu Trp Lys Gln Gln Gln Leu Val Ser Gly
    1010                1015                1020                
Met Ala Glu Arg Asn Ala Asn Phe Glu Ala Leu Pro Glu Asp Trp Arg
1025                1030                1035                1040
Ala Arg Leu Lys Arg Arg Lys Met Ala Pro Asn Thr
                1045                1050        


<210> 6387
<211> 1050
<212> PRT
<213> Homo sapiens

<400> 6387
Ile Leu Ile Thr Arg Arg Ser Ala Gln Gly Pro Ala Pro Ser Leu Gln
 1               5                  10                  15      
Cys Pro Pro Leu Ser Ala Ala Arg Arg Ser Leu Leu Ala Leu Gly Leu
            20                  25                  30          
Ala Met Gly Lys Lys Ser Arg Ala Val Pro Gly Arg Arg Pro Ile Leu
        35                  40                  45              
Gln Leu Ser Pro Pro Gly Pro Arg Gly Ser Thr Pro Gly Arg Asp Pro
    50                  55                  60                  
Glu Pro Glu Pro Asp Thr Glu Pro Asp Ser Thr Ala Ala Val Pro Ser
65                  70                  75                  80  
Gln Pro Ala Pro Ser Ala Ala Thr Thr Thr Ala Val Thr Ala Ala Ala
                85                  90                  95      
Ala Ser Asp Asp Ser Pro Ser Glu Gly Lys Asp Glu Gln Glu Ala Val
            100                 105                 110         
Gln Glu Val Pro Arg Val Val Gln Asn Pro Pro Lys Pro Val Met Thr
        115                 120                 125             
Thr Arg Pro Thr Ala Val Lys Ala Thr Gly Gly Leu Cys Leu Leu Gly
    130                 135                 140                 
Ala Tyr Ala Asp Ser Asp Asp Asp Asp Asn Asp Val Ser Glu Lys Leu
145                 150                 155                 160 
Ala Gln Ser Lys Glu Thr Asn Gly Asn Gln Ser Thr Asp Ile Asp Ser
                165                 170                 175     
Thr Leu Ala Asn Phe Leu Ala Glu Ile Asp Ala Ile Thr Ala Pro Gln
            180                 185                 190         
Pro Ala Ala Pro Val Gly Ala Ser Ala Pro Pro Pro Thr Pro Pro Arg
        195                 200                 205             
Pro Glu Pro Lys Glu Ala Ala Thr Ser Thr Leu Ser Ser Ser Thr Ser
    210                 215                 220                 
Asn Gly Thr Asp Ser Thr Gln Thr Ser Gly Trp Gln Tyr Asp Thr Gln
225                 230                 235                 240 
Cys Ser Leu Ala Gly Val Gly Ile Glu Met Gly Asp Trp Gln Glu Val
                245                 250                 255     
Trp Asp Glu Asn Thr Gly Cys Tyr Tyr Tyr Trp Asn Thr Gln Thr Asn
            260                 265                 270         
Glu Val Thr Trp Glu Leu Pro Gln Tyr Leu Ala Thr Gln Val Gln Gly
        275                 280                 285             
Leu Gln His Tyr Gln Pro Ser Ser Val Pro Gly Ala Glu Thr Ser Phe
    290                 295                 300                 
Val Val Asn Thr Asp Ile Tyr Ser Lys Glu Lys Thr Ile Ser Val Ser
305                 310                 315                 320 
Ser Ser Lys Ser Gly Pro Val Ile Ala Lys Arg Glu Val Lys Lys Glu
                325                 330                 335     
Val Asn Glu Gly Ile Gln Ala Leu Ser Asn Ser Glu Glu Glu Lys Lys
            340                 345                 350         
Gly Val Ala Ala Ser Leu Leu Ala Pro Leu Leu Pro Glu Gly Ile Lys
        355                 360                 365             
Glu Glu Glu Glu Arg Trp Arg Arg Lys Val Ile Cys Lys Glu Glu Pro
    370                 375                 380                 
Val Ser Glu Val Lys Glu Thr Ser Thr Thr Val Glu Glu Ala Thr Thr
385                 390                 395                 400 
Ile Val Lys Pro Gln Glu Ile Met Leu Asp Asn Ile Glu Asp Pro Ser
                405                 410                 415     
Gln Glu Asp Leu Cys Ser Val Val Gln Ser Gly Glu Ser Glu Glu Glu
            420                 425                 430         
Glu Glu Gln Asp Thr Leu Glu Leu Glu Leu Val Leu Glu Arg Lys Lys
        435                 440                 445             
Ala Glu Leu Arg Ala Leu Glu Glu Gly Asp Gly Ser Val Ser Gly Ser
    450                 455                 460                 
Ser Pro Arg Ser Asp Ile Ser Gln Pro Ala Ser Gln Asp Gly Met Arg
465                 470                 475                 480 
Arg Leu Met Ser Lys Arg Gly Lys Trp Lys Met Phe Val Arg Ala Thr
                485                 490                 495     
Ser Pro Glu Ser Thr Ser Arg Ser Ser Ser Lys Thr Gly Arg Asp Thr
            500                 505                 510         
Pro Glu Asn Gly Glu Thr Ala Ile Gly Ala Glu Asn Ser Glu Lys Ile
        515                 520                 525             
Asp Glu Asn Ser Asp Lys Glu Met Glu Val Glu Glu Ser Pro Glu Lys
    530                 535                 540                 
Ile Lys Val Gln Thr Thr Pro Lys Val Glu Glu Glu Gln Asp Leu Lys
545                 550                 555                 560 
Phe Gln Ile Gly Glu Leu Ala Asn Thr Leu Thr Ser Lys Phe Glu Phe
                565                 570                 575     
Leu Gly Ile Asn Arg Gln Ser Ile Ser Asn Phe His Val Leu Leu Leu
            580                 585                 590         
Gln Thr Glu Thr Arg Ile Ala Asp Trp Arg Glu Gly Ala Leu Asn Gly
        595                 600                 605             
Asn Tyr Leu Lys Arg Lys Leu Gln Asp Ala Ala Glu Gln Leu Lys Gln
    610                 615                 620                 
Tyr Glu Ile Asn Ala Thr Pro Lys Gly Trp Ser Cys His Trp Asp Arg
625                 630                 635                 640 
Asp His Arg Arg Tyr Phe Tyr Val Asn Glu Gln Ser Gly Glu Ser Gln
                645                 650                 655     
Trp Glu Phe Pro Asp Gly Glu Glu Glu Glu Glu Glu Ser Gln Ala Gln
            660                 665                 670         
Glu Asn Arg Asp Glu Thr Leu Ala Lys Gln Thr Leu Lys Asp Lys Thr
        675                 680                 685             
Gly Thr Asp Ser Asn Ser Thr Glu Ser Ser Glu Thr Ser Thr Gly Ser
    690                 695                 700                 
Leu Cys Lys Glu Ser Phe Ser Gly Gln Val Ser Ser Ser Ser Leu Met
705                 710                 715                 720 
Pro Leu Thr Pro Phe Trp Thr Leu Leu Gln Ser Asn Val Pro Val Leu
                725                 730                 735     
Gln Pro Pro Leu Pro Leu Glu Met Pro Pro Pro Pro Pro Pro Pro Pro
            740                 745                 750         
Glu Ser Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Asp Gly
        755                 760                 765             
Glu Ile Gln Glu Val Glu Met Glu Asp Glu Gly Ser Glu Glu Pro Pro
    770                 775                 780                 
Ala Pro Gly Thr Glu Glu Asp Thr Pro Leu Lys Pro Ser Ala Gln Thr
785                 790                 795                 800 
Thr Val Val Thr Ser Gln Ser Ser Val Asp Ser Thr Ile Ser Ser Ser
                805                 810                 815     
Ser Ser Thr Lys Gly Ile Lys Arg Lys Ala Thr Glu Ile Ser Thr Ala
            820                 825                 830         
Val Val Gln Arg Ser Ala Thr Ile Gly Ser Ser Pro Val Leu Tyr Ser
        835                 840                 845             
Gln Ser Ala Ile Ala Thr Gly His Gln Ala Ala Gly Ile Gly Asn Gln
    850                 855                 860                 
Ala Thr Gly Ile Gly His Gln Thr Ile Pro Val Ser Leu Pro Ala Ala
865                 870                 875                 880 
Gly Met Gly His Gln Ala Arg Gly Met Ser Leu Gln Ser Asn Tyr Leu
                885                 890                 895     
Gly Leu Ala Ala Ala Pro Ala Ile Met Ser Tyr Ala Glu Cys Ser Val
            900                 905                 910         
Pro Ile Gly Val Thr Ala Pro Ser Leu Gln Pro Val Gln Ala Arg Gly
        915                 920                 925             
Ala Val Pro Thr Ala Thr Ile Ile Glu Pro Pro Pro Pro Pro Pro Pro
    930                 935                 940                 
Pro Pro Pro Pro Pro Pro Pro Ala Pro Lys Met Pro Pro Pro Glu Lys
945                 950                 955                 960 
Thr Lys Lys Gly Arg Lys Asp Lys Ala Lys Lys Ser Lys Thr Lys Met
                965                 970                 975     
Pro Ser Leu Val Lys Lys Trp Gln Ser Ile Gln Arg Glu Leu Asp Glu
            980                 985                 990         
Glu Asp Asn Ser Ser Ser Ser Glu Glu Asp Arg Glu Ser Thr Ala Gln
        995                 1000                1005            
Lys Arg Ile Glu Glu Trp Lys Gln Gln Gln Leu Val Ser Gly Met Ala
    1010                1015                1020                
Glu Arg Asn Ala Asn Phe Glu Ala Leu Pro Glu Asp Trp Arg Ala Arg
1025                1030                1035                1040
Leu Lys Arg Arg Lys Met Ala Pro Asn Thr
                1045                1050


<210> 6388
<211> 1253
<212> PRT
<213> Homo sapiens

<400> 6388
Met Lys Ile Ile Thr Tyr Phe Cys Ile Trp Ala Val Ala Trp Ala Ile
 1               5                  10                  15      
Pro Val Pro Gln Ser Lys Pro Leu Glu Arg His Val Glu Lys Ser Met
            20                  25                  30          
Asn Leu His Leu Leu Ala Arg Ser Asn Val Ser Val Gln Asp Glu Leu
        35                  40                  45              
Asn Ala Ser Gly Thr Ile Lys Glu Ser Gly Val Leu Val His Glu Gly
    50                  55                  60                  
Asp Arg Gly Arg Gln Glu Asn Thr Gln Asp Gly His Lys Gly Glu Gly
65                  70                  75                  80  
Asn Gly Ser Lys Trp Ala Glu Val Gly Gly Lys Ser Phe Ser Thr Tyr
                85                  90                  95      
Ser Thr Leu Ala Asn Glu Glu Gly Asn Ile Glu Gly Trp Asn Gly Asp
            100                 105                 110         
Thr Gly Lys Ala Glu Thr Tyr Gly His Asp Gly Ile His Gly Lys Glu
        115                 120                 125             
Glu Asn Ile Thr Ala Asn Gly Ile Gln Gly Gln Val Ser Ile Ile Asp
    130                 135                 140                 
Asn Ala Gly Ala Thr Asn Arg Ser Asn Thr Asn Gly Asn Thr Asp Lys
145                 150                 155                 160 
Asn Thr Gln Asn Gly Asp Val Gly Asp Ala Gly His Asn Glu Asp Val
                165                 170                 175     
Ala Val Val Gln Glu Asp Gly Pro Gln Val Ala Gly Ser Asn Asn Ser
            180                 185                 190         
Thr Asp Asn Glu Asp Glu Ile Ile Glu Asn Ser Cys Arg Asn Glu Gly
        195                 200                 205             
Asn Thr Ser Glu Ile Thr Pro Gln Ile Asn Ser Lys Arg Asn Gly Thr
    210                 215                 220                 
Lys Glu Ala Glu Val Thr Pro Gly Thr Gly Glu Asp Ala Gly Leu Asp
225                 230                 235                 240 
Asn Ser Asp Gly Ser Pro Ser Gly Asn Gly Ala Asp Glu Asp Glu Asp
                245                 250                 255     
Glu Gly Ser Gly Asp Asp Glu Asp Glu Glu Ala Gly Asn Gly Lys Asp
            260                 265                 270         
Ser Ser Asn Asn Ser Lys Gly Gln Glu Gly Gln Asp His Gly Lys Glu
        275                 280                 285             
Asp Asp His Asp Ser Ser Ile Gly Gln Asn Ser Asp Ser Lys Glu Tyr
    290                 295                 300                 
Tyr Asp Pro Glu Gly Lys Glu Asp Pro His Asn Glu Val Asp Gly Asp
305                 310                 315                 320 
Lys Thr Ser Lys Ser Glu Glu Asn Ser Ala Gly Ile Pro Glu Asp Asn
                325                 330                 335     
Gly Ser Gln Arg Ile Glu Asp Thr Gln Lys Leu Asn His Arg Glu Ser
            340                 345                 350         
Lys Arg Val Glu Asn Arg Ile Thr Lys Glu Ser Glu Thr His Ala Val
        355                 360                 365             
Gly Lys Ser Gln Asp Lys Gly Ile Glu Ile Lys Gly Pro Ser Ser Gly
    370                 375                 380                 
Asn Arg Asn Ile Thr Lys Glu Val Gly Lys Gly Asn Glu Gly Lys Glu
385                 390                 395                 400 
Asp Lys Gly Gln His Gly Met Ile Leu Gly Lys Gly Asn Val Lys Thr
                405                 410                 415     
Gln Gly Glu Val Val Asn Ile Glu Gly Pro Gly Gln Lys Ser Glu Pro
            420                 425                 430         
Gly Asn Lys Val Gly His Ser Asn Thr Gly Ser Asp Ser Asn Ser Asp
        435                 440                 445             
Gly Tyr Asp Ser Tyr Asp Phe Asp Asp Lys Ser Met Gln Gly Asp Asp
    450                 455                 460                 
Pro Asn Ser Ser Asp Glu Ser Asn Gly Asn Asp Asp Ala Asn Ser Glu
465                 470                 475                 480 
Ser Asp Asn Asn Ser Ser Ser Arg Gly Asp Ala Ser Tyr Asn Ser Asp
                485                 490                 495     
Glu Ser Lys Asp Asn Gly Asn Gly Ser Asp Ser Lys Gly Ala Glu Asp
            500                 505                 510         
Asp Asp Ser Asp Ser Thr Ser Asp Thr Asn Asn Ser Asp Ser Asn Gly
        515                 520                 525             
Asn Gly Asn Asn Gly Asn Asp Asp Asn Asp Lys Ser Asp Ser Gly Lys
    530                 535                 540                 
Gly Lys Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser
545                 550                 555                 560 
Ser Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Asn Ser
                565                 570                 575     
Ser Ser Asp Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp
            580                 585                 590         
Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser
        595                 600                 605             
Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Lys Ser
    610                 615                 620                 
Asp Ser Ser Lys Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Lys Ser
625                 630                 635                 640 
Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser Ser Asp Asn Ser Asp Ser
                645                 650                 655     
Ser Asp Ser Ser Asn Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser
            660                 665                 670         
Asp Ser Ser Asp Ser Ser Ser Ser Ser Asp Ser Ser Ser Ser Ser Asp
        675                 680                 685             
Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser
    690                 695                 700                 
Ser Glu Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp
705                 710                 715                 720 
Ser Ser Asp Ser Ser Asn Ser Asn Ser Ser Asp Ser Asp Ser Ser Asn
                725                 730                 735     
Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser
            740                 745                 750         
Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser
        755                 760                 765             
Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp
    770                 775                 780                 
Ser Asn Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser
785                 790                 795                 800 
Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser
                805                 810                 815     
Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser
            820                 825                 830         
Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser
        835                 840                 845             
Asp Ser Ser Asp Ser Asp Ser Ser Asn Arg Ser Asp Ser Ser Asn Ser
    850                 855                 860                 
Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser
865                 870                 875                 880 
Asp Ser Ser Asp Ser Ser Asp Ser Asn Glu Ser Ser Asn Ser Ser Asp
                885                 890                 895     
Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser
            900                 905                 910         
Asn Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Glu
        915                 920                 925             
Ser Ser Asn Ser Ser Asp Asn Ser Asn Ser Ser Asp Ser Ser Asn Ser
    930                 935                 940                 
Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser
945                 950                 955                 960 
Asn Ser Gly Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Asn Ser
                965                 970                 975     
Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser
            980                 985                 990         
Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp
        995                 1000                1005            
Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser
    1010                1015                1020                
Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser
1025                1030                1035                1040
Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp
                1045                1050                1055    
Ser Ser Asp Ser Ser Asp Ser Ser Gly Ser Ser Asp Ser Ser Asp Ser
            1060                1065                1070        
Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser
        1075                1080                1085            
Asp Ser Ser Asp Ser Ser Glu Ser Ser Asp Ser Ser Asp Ser Ser Asp
    1090                1095                1100                
Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser
1105                1110                1115                1120
Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser
                1125                1130                1135    
Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp
            1140                1145                1150        
Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser
        1155                1160                1165            
Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Asn
    1170                1175                1180                
Glu Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn
1185                1190                1195                1200
Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Thr Ser Asp
                1205                1210                1215    
Ser Asn Asp Glu Ser Asp Ser Gln Ser Lys Ser Gly Asn Gly Asn Asn
            1220                1225                1230        
Asn Gly Ser Asp Ser Asp Ser Asp Ser Glu Gly Ser Asp Ser Asn His
        1235                1240                1245            
Ser Thr Ser Asp Asp
    1250            


<210> 6389
<211> 306
<212> PRT
<213> Homo sapiens

<400> 6389
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Gly
 1               5                  10                  15      
Arg Gly Ser Gly Pro Gly Arg Arg Arg His Leu Val Pro Gly Ala Gly
            20                  25                  30          
Gly Glu Ala Gly Glu Gly Ala Pro Gly Gly Ala Gly Asp Tyr Gly Asn
        35                  40                  45              
Gly Leu Glu Ser Glu Glu Leu Glu Pro Glu Glu Leu Leu Leu Glu Pro
    50                  55                  60                  
Glu Pro Glu Pro Glu Pro Glu Glu Glu Pro Pro Arg Pro Arg Ala Pro
65                  70                  75                  80  
Pro Gly Ala Pro Gly Pro Gly Pro Gly Ser Gly Ala Pro Gly Ser Gln
                85                  90                  95      
Glu Glu Glu Glu Glu Pro Gly Leu Val Glu Gly Asp Pro Gly Asp Gly
            100                 105                 110         
Ala Ile Glu Asp Pro Glu Leu Glu Ala Ile Lys Ala Arg Val Arg Glu
        115                 120                 125             
Met Glu Glu Glu Ala Glu Lys Leu Lys Glu Leu Gln Asn Glu Val Glu
    130                 135                 140                 
Lys Gln Met Asn Met Ser Pro Pro Pro Gly Asn Ala Gly Pro Val Ile
145                 150                 155                 160 
Met Ser Ile Glu Glu Lys Met Glu Ala Asp Ala Arg Ser Ile Tyr Val
                165                 170                 175     
Gly Asn Val Asp Tyr Gly Ala Thr Ala Glu Glu Leu Glu Ala His Phe
            180                 185                 190         
His Gly Cys Gly Ser Val Asn Arg Val Thr Ile Leu Cys Asp Lys Phe
        195                 200                 205             
Ser Gly His Pro Lys Gly Phe Ala Tyr Ile Glu Phe Ser Asp Lys Glu
    210                 215                 220                 
Ser Val Arg Thr Ser Leu Ala Leu Asp Glu Ser Leu Phe Arg Gly Arg
225                 230                 235                 240 
Gln Ile Lys Val Ile Pro Lys Arg Thr Asn Arg Pro Gly Ile Ser Thr
                245                 250                 255     
Thr Asp Arg Gly Phe Pro Arg Ala Arg Tyr Arg Ala Arg Thr Thr Asn
            260                 265                 270         
Tyr Asn Ser Ser Arg Ser Arg Phe Tyr Ser Gly Phe Asn Ser Arg Pro
        275                 280                 285             
Arg Gly Arg Val Tyr Arg Gly Arg Ala Arg Ala Thr Ser Trp Tyr Ser
    290                 295                 300                 
Pro Tyr
305     


<210> 6390
<211> 385
<212> PRT
<213> Homo sapiens

<400> 6390
Met Ser Arg Pro Gln Leu Arg Arg Trp Arg Leu Val Ser Ser Pro Pro
 1               5                  10                  15      
Ser Gly Val Pro Gly Leu Ala Leu Leu Ala Leu Leu Ala Leu Leu Ala
            20                  25                  30          
Leu Arg Leu Ala Ala Gly Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu
        35                  40                  45              
Cys Arg Pro Ile Arg His His Pro Asp Phe Glu Val Phe Val Phe Asp
    50                  55                  60                  
Val Gly Gln Lys Thr Trp Lys Ser Tyr Asp Trp Ser Gln Ile Thr Thr
65                  70                  75                  80  
Val Ala Thr Phe Gly Lys Tyr Asp Ser Glu Leu Met Cys Tyr Ala His
                85                  90                  95      
Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp Val Ser Leu Lys Asp
            100                 105                 110         
Ile Ile Asp Pro Ala Phe Arg Ala Ser Trp Ile Ala Gln Lys Leu Asn
        115                 120                 125             
Leu Ala Lys Thr Gln Tyr Met Asp Gly Ile Asn Ile Asp Ile Glu Gln
    130                 135                 140                 
Glu Val Asn Cys Leu Ser Pro Glu Tyr Asp Ala Leu Thr Ala Leu Val
145                 150                 155                 160 
Lys Glu Thr Thr Asp Ser Phe His Arg Glu Ile Glu Gly Ser Gln Val
                165                 170                 175     
Thr Phe Asp Val Ala Trp Ser Pro Lys Asn Ile Asp Arg Arg Cys Tyr
            180                 185                 190         
Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe Leu Phe Val Met Ser
        195                 200                 205             
Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala Ala Asn
    210                 215                 220                 
Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile Lys Met
225                 230                 235                 240 
Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val Pro Trp Tyr Gly Tyr
                245                 250                 255     
Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His Val Cys Thr Ile Ala
            260                 265                 270         
Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly Arg Gln
        275                 280                 285             
Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn Ser Ser Ile Ser Gly
    290                 295                 300                 
Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr Tyr Asn Tyr Lys Asp
305                 310                 315                 320 
Pro Ala Gly His Phe His Gln Val Trp Tyr Asp Asn Pro Gln Ser Ile
                325                 330                 335     
Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg Leu Arg Gly Ile Gly
            340                 345                 350         
Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly Asp Ala Val Ala Lys
        355                 360                 365             
Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys Pro Lys Leu Leu Gln
    370                 375                 380                 
Arg
385 


<210> 6391
<211> 215
<212> PRT
<213> Homo sapiens

<400> 6391
Met His Arg Asp Ala Trp Leu Pro Arg Pro Ala Phe Ser Leu Thr Gly
 1               5                  10                  15      
Leu Ser Leu Phe Phe Ser Leu Val Pro Pro Gly Arg Ser Met Glu Val
            20                  25                  30          
Thr Val Pro Ala Thr Leu Asn Val Leu Asn Gly Ser Asp Ala Arg Leu
        35                  40                  45              
Pro Cys Thr Phe Asn Ser Cys Tyr Thr Val Asn His Lys Gln Phe Ser
    50                  55                  60                  
Leu Asn Trp Thr Tyr Gln Glu Cys Asn Asn Cys Ser Glu Glu Met Phe
65                  70                  75                  80  
Leu Gln Phe Arg Met Lys Ile Ile Asn Leu Lys Leu Glu Arg Phe Gln
                85                  90                  95      
Asp Arg Val Glu Phe Ser Gly Asn Pro Ser Lys Tyr Asp Val Ser Val
            100                 105                 110         
Met Leu Arg Asn Val Gln Pro Glu Asp Glu Gly Ile Tyr Asn Cys Tyr
        115                 120                 125             
Ile Met Asn Pro Pro Asp Arg His Arg Gly His Gly Lys Ile His Leu
    130                 135                 140                 
Gln Val Leu Met Glu Glu Pro Pro Glu Arg Asp Ser Thr Val Ala Val
145                 150                 155                 160 
Ile Val Gly Ala Ser Val Gly Gly Phe Leu Ala Val Val Ile Leu Val
                165                 170                 175     
Leu Met Val Val Lys Cys Val Arg Arg Lys Lys Glu Gln Lys Leu Ser
            180                 185                 190         
Thr Asp Asp Leu Lys Thr Glu Glu Glu Gly Lys Thr Asp Gly Glu Gly
        195                 200                 205             
Asn Pro Asp Asp Gly Ala Lys
    210                 215 


<210> 6392
<211> 508
<212> PRT
<213> Homo sapiens

<400> 6392
Met Trp Glu Leu Val Ala Leu Leu Leu Leu Thr Leu Ala Tyr Leu Phe
 1               5                  10                  15      
Trp Pro Lys Arg Arg Cys Pro Gly Ala Lys Tyr Pro Lys Ser Leu Leu
            20                  25                  30          
Ser Leu Pro Leu Val Gly Ser Leu Pro Phe Leu Pro Arg His Gly His
        35                  40                  45              
Met His Asn Asn Phe Phe Lys Leu Gln Lys Lys Tyr Gly Pro Ile Tyr
    50                  55                  60                  
Ser Val Arg Met Gly Thr Lys Thr Thr Val Ile Val Gly His His Gln
65                  70                  75                  80  
Leu Ala Lys Glu Val Leu Ile Lys Lys Gly Lys Asp Phe Ser Gly Arg
                85                  90                  95      
Pro Gln Met Ala Thr Leu Asp Ile Ala Ser Asn Asn Arg Lys Gly Ile
            100                 105                 110         
Ala Phe Ala Asp Ser Gly Ala His Trp Gln Leu His Arg Arg Leu Ala
        115                 120                 125             
Met Ala Thr Phe Ala Leu Phe Lys Asp Gly Asp Gln Lys Leu Glu Lys
    130                 135                 140                 
Ile Ile Cys Gln Glu Ile Ser Thr Leu Cys Asp Met Leu Ala Thr His
145                 150                 155                 160 
Asn Gly Gln Ser Ile Asp Ile Ser Phe Pro Val Phe Val Ala Val Thr
                165                 170                 175     
Asn Val Ile Ser Leu Ile Cys Phe Asn Thr Ser Tyr Lys Asn Gly Asp
            180                 185                 190         
Pro Glu Leu Asn Val Ile Gln Asn Tyr Asn Glu Gly Ile Ile Asp Asn
        195                 200                 205             
Leu Ser Lys Asp Ser Leu Val Asp Leu Val Pro Trp Leu Lys Ile Phe
    210                 215                 220                 
Pro Asn Lys Thr Leu Glu Lys Leu Lys Ser His Val Lys Ile Arg Asn
225                 230                 235                 240 
Asp Leu Leu Asn Lys Ile Leu Glu Asn Tyr Lys Glu Lys Phe Arg Ser
                245                 250                 255     
Asp Ser Ile Thr Asn Met Leu Asp Thr Leu Met Gln Ala Lys Met Asn
            260                 265                 270         
Ser Asp Asn Gly Asn Ala Gly Pro Asp Gln Asp Ser Glu Leu Leu Ser
        275                 280                 285             
Asp Asn His Ile Leu Thr Thr Ile Gly Asp Ile Phe Gly Ala Gly Val
    290                 295                 300                 
Glu Thr Thr Thr Ser Val Val Lys Trp Thr Leu Ala Phe Leu Leu His
305                 310                 315                 320 
Asn Pro Gln Val Lys Lys Lys Leu Tyr Glu Glu Ile Asp Gln Asn Val
                325                 330                 335     
Gly Phe Ser Arg Thr Pro Thr Ile Ser Asp Arg Asn Arg Leu Leu Leu
            340                 345                 350         
Leu Glu Ala Thr Ile Arg Glu Val Leu Arg Leu Arg Pro Val Ala Pro
        355                 360                 365             
Met Leu Ile Pro His Lys Ala Asn Val Asp Ser Ser Ile Gly Glu Phe
    370                 375                 380                 
Ala Val Asp Lys Gly Thr Glu Val Ile Ile Asn Leu Trp Ala Leu His
385                 390                 395                 400 
His Asn Glu Lys Glu Trp His Gln Pro Asp Gln Phe Met Pro Glu Arg
                405                 410                 415     
Phe Leu Asn Pro Ala Gly Thr Gln Leu Ile Ser Pro Ser Val Ser Tyr
            420                 425                 430         
Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Ile Gly Glu Ile Leu Ala
        435                 440                 445             
Arg Gln Glu Leu Phe Leu Ile Met Ala Trp Leu Leu Gln Arg Phe Asp
    450                 455                 460                 
Leu Glu Val Pro Asp Asp Gly Gln Leu Pro Ser Leu Glu Gly Ile Pro
465                 470                 475                 480 
Lys Val Val Phe Leu Ile Asp Ser Phe Lys Val Lys Ile Lys Val Arg
                485                 490                 495     
Gln Ala Trp Arg Glu Ala Gln Ala Glu Gly Ser Thr
            500                 505             


<210> 6393
<211> 811
<212> PRT
<213> Homo sapiens

<400> 6393
Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr
 1               5                  10                  15      
Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr
            20                  25                  30          
Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro
        35                  40                  45              
Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln
    50                  55                  60                  
Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys
65                  70                  75                  80  
His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys
                85                  90                  95      
Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr
            100                 105                 110         
Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp
        115                 120                 125             
Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu
    130                 135                 140                 
Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln
145                 150                 155                 160 
Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr
                165                 170                 175     
Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys
            180                 185                 190         
Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg
        195                 200                 205             
Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly
    210                 215                 220                 
Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu
225                 230                 235                 240 
Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp
                245                 250                 255     
Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu
            260                 265                 270         
His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp
        275                 280                 285             
His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu
    290                 295                 300                 
Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr
305                 310                 315                 320 
Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala
                325                 330                 335     
Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr
            340                 345                 350         
Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr
        355                 360                 365             
Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu
    370                 375                 380                 
Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu
385                 390                 395                 400 
His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn
                405                 410                 415     
Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys
            420                 425                 430         
Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu
        435                 440                 445             
Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His
    450                 455                 460                 
Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp
465                 470                 475                 480 
Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu
                485                 490                 495     
Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln
            500                 505                 510         
Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys
        515                 520                 525             
Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met
    530                 535                 540                 
Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg
545                 550                 555                 560 
Gly Ile Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr
                565                 570                 575     
Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu
            580                 585                 590         
Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg
        595                 600                 605             
Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr
    610                 615                 620                 
Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr
625                 630                 635                 640 
Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu
                645                 650                 655     
Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe
            660                 665                 670         
Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys
        675                 680                 685             
Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu
    690                 695                 700                 
Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu
705                 710                 715                 720 
Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr
                725                 730                 735     
Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys
            740                 745                 750         
Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp
        755                 760                 765             
Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu
    770                 775                 780                 
Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly
785                 790                 795                 800 
Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu
                805                 810     


<210> 6394
<211> 352
<212> PRT
<213> Homo sapiens

<400> 6394
Met Leu Leu Phe Ser Val Leu Leu Leu Leu Ser Leu Val Thr Gly Thr
 1               5                  10                  15      
Gln Leu Gly Pro Arg Thr Pro Leu Pro Glu Ala Gly Val Ala Ile Leu
            20                  25                  30          
Gly Arg Ala Arg Gly Ala His Arg Pro Gln Pro Arg His Pro Pro Ser
        35                  40                  45              
Pro Val Ser Glu Cys Gly Asp Arg Ser Ile Phe Glu Gly Arg Thr Arg
    50                  55                  60                  
Tyr Ser Arg Ile Thr Gly Gly Met Glu Ala Glu Val Gly Glu Phe Pro
65                  70                  75                  80  
Trp Gln Val Ser Ile Gln Ala Arg Ser Glu Pro Phe Cys Gly Gly Ser
                85                  90                  95      
Ile Leu Asn Lys Trp Trp Ile Leu Thr Ala Ala His Cys Leu Tyr Ser
            100                 105                 110         
Glu Glu Leu Phe Pro Glu Glu Leu Ser Val Val Leu Gly Thr Asn Asp
        115                 120                 125             
Leu Thr Ser Pro Ser Met Glu Ile Lys Glu Val Ala Ser Ile Ile Leu
    130                 135                 140                 
His Lys Asp Phe Lys Arg Ala Asn Met Asp Asn Asp Ile Ala Leu Leu
145                 150                 155                 160 
Leu Leu Ala Ser Pro Ile Lys Leu Asp Asp Leu Lys Val Pro Ile Cys
                165                 170                 175     
Leu Pro Thr Gln Pro Gly Pro Ala Thr Trp Arg Glu Cys Trp Val Ala
            180                 185                 190         
Gly Trp Gly Gln Thr Asn Ala Ala Asp Lys Asn Ser Val Lys Thr Asp
        195                 200                 205             
Leu Met Lys Val Pro Met Val Ile Met Asp Trp Glu Glu Cys Ser Lys
    210                 215                 220                 
Met Phe Pro Lys Leu Thr Lys Asn Met Leu Cys Ala Gly Tyr Lys Asn
225                 230                 235                 240 
Glu Ser Tyr Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys
                245                 250                 255     
Thr Pro Glu Pro Gly Glu Lys Trp Tyr Gln Val Gly Ile Ile Ser Trp
            260                 265                 270         
Gly Lys Ser Cys Gly Glu Lys Asn Thr Pro Gly Ile Tyr Thr Ser Leu
        275                 280                 285             
Val Asn Tyr Asn Leu Trp Ile Glu Lys Val Thr Gln Leu Glu Gly Arg
    290                 295                 300                 
Pro Phe Asn Ala Glu Lys Arg Arg Thr Ser Val Lys Gln Lys Pro Met
305                 310                 315                 320 
Gly Ser Pro Val Ser Gly Val Pro Glu Pro Gly Ser Pro Arg Ser Trp
                325                 330                 335     
Leu Leu Leu Cys Pro Leu Ser His Val Leu Phe Arg Ala Ile Leu Tyr
            340                 345                 350         


<210> 6395
<211> 417
<212> PRT
<213> Homo sapiens

<400> 6395
Met Arg Cys Leu Cys Ala Ala Val Pro Glu Thr Lys Gln Pro Glu Lys
 1               5                  10                  15      
Lys Ser Ser Trp Leu Gln Ser Glu Phe Leu Ala Pro Gln Pro Ile Val
            20                  25                  30          
Thr Ser Leu Gly Gly Ser Gly Ser Glu Leu Glu Ala Leu Ser Leu Thr
        35                  40                  45              
Ala Ser Ala Leu Ala Ser Val Thr Pro Gly Pro Thr Ala Gln Pro Arg
    50                  55                  60                  
Ala Met Leu Leu Phe Ser Val Leu Leu Leu Leu Ser Leu Val Thr Gly
65                  70                  75                  80  
Thr Gln Leu Gly Pro Arg Thr Pro Leu Pro Glu Ala Gly Val Ala Ile
                85                  90                  95      
Leu Gly Arg Ala Arg Gly Ala His Arg Pro Gln Pro Pro His Pro Pro
            100                 105                 110         
Ser Pro Val Ser Glu Cys Gly Asp Arg Ser Ile Phe Glu Gly Arg Thr
        115                 120                 125             
Arg Tyr Ser Arg Ile Thr Gly Gly Met Glu Ala Glu Val Gly Glu Phe
    130                 135                 140                 
Pro Trp Gln Val Ser Ile Gln Ala Arg Ser Glu Pro Phe Cys Gly Gly
145                 150                 155                 160 
Ser Ile Leu Asn Lys Trp Trp Ile Leu Thr Ala Ala His Cys Leu Tyr
                165                 170                 175     
Ser Glu Glu Leu Phe Pro Glu Glu Leu Ser Val Val Leu Gly Thr Asn
            180                 185                 190         
Asp Leu Thr Ser Pro Ser Met Glu Ile Lys Glu Val Ala Ser Ile Ile
        195                 200                 205             
Leu His Lys Asp Phe Lys Arg Ala Asn Met Asp Asn Asp Ile Ala Leu
    210                 215                 220                 
Leu Leu Leu Ala Ser Pro Ile Lys Leu Asp Asp Leu Lys Val Pro Ile
225                 230                 235                 240 
Cys Leu Pro Thr Gln Pro Gly Pro Ala Thr Trp Arg Glu Cys Trp Val
                245                 250                 255     
Ala Gly Trp Gly Gln Thr Asn Ala Ala Asp Lys Asn Ser Val Lys Thr
            260                 265                 270         
Asp Leu Met Lys Ala Pro Met Val Ile Met Asp Trp Glu Glu Cys Ser
        275                 280                 285             
Lys Met Phe Pro Lys Leu Thr Lys Asn Met Leu Cys Ala Gly Tyr Lys
    290                 295                 300                 
Asn Glu Ser Tyr Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val
305                 310                 315                 320 
Cys Thr Pro Glu Pro Gly Glu Lys Trp Tyr Gln Val Gly Ile Ile Ser
                325                 330                 335     
Trp Gly Lys Ser Cys Gly Glu Lys Asn Thr Pro Gly Ile Tyr Thr Ser
            340                 345                 350         
Leu Val Asn Tyr Asn Leu Trp Ile Glu Lys Val Thr Gln Leu Glu Gly
        355                 360                 365             
Arg Pro Phe Asn Ala Glu Lys Arg Arg Thr Ser Val Lys Gln Lys Pro
    370                 375                 380                 
Met Gly Ser Pro Val Ser Gly Val Pro Glu Pro Gly Ser Pro Arg Ser
385                 390                 395                 400 
Trp Leu Leu Leu Cys Pro Leu Ser His Val Leu Phe Arg Ala Ile Leu
                405                 410                 415     
Tyr
    


<210> 6396
<211> 474
<212> PRT
<213> Homo sapiens

<400> 6396
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Asn
 1               5                  10                  15      
Ser Phe Ala Glu Pro Ser Arg Ser Asn Gly Ser Met Val Arg His Ser
            20                  25                  30          
Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys Pro Phe Leu Asn Ser
        35                  40                  45              
Asp Leu Arg Arg Ser Pro Ser Lys Pro Thr Leu Ala Tyr Pro Glu Ser
    50                  55                  60                  
Asn Ser Arg Ala Ile Phe Ser Ala Leu Lys Asn Leu Gln Asp Lys Ile
65                  70                  75                  80  
Arg Arg Leu Glu Leu Glu Arg Ile Gln Ala Glu Glu Ser Val Lys Thr
                85                  90                  95      
Leu Ser Arg Glu Thr Ile Glu Tyr Lys Lys Val Leu Asp Glu Gln Ile
            100                 105                 110         
Gln Glu Arg Glu Asn Ser Lys Asn Glu Glu Ser Lys His Asn Gln Glu
        115                 120                 125             
Leu Thr Ser Gln Leu Leu Ala Ala Glu Asn Lys Cys Asn Leu Leu Glu
    130                 135                 140                 
Lys Gln Leu Glu Tyr Met Arg Asn Met Ile Lys His Ala Glu Met Glu
145                 150                 155                 160 
Arg Thr Ser Val Leu Glu Lys Gln Val Ser Leu Glu Arg Glu Arg Gln
                165                 170                 175     
His Asp Gln Thr His Val Gln Ser Gln Leu Glu Lys Leu Asp Leu Leu
            180                 185                 190         
Glu Gln Glu Tyr Asn Lys Leu Thr Thr Met Gln Ala Leu Ala Glu Lys
        195                 200                 205             
Lys Met Gln Glu Leu Glu Ala Lys Leu His Glu Glu Glu Gln Glu Arg
    210                 215                 220                 
Lys Arg Met Gln Ala Lys Ala Ala Glu Leu Gln Thr Gly Leu Glu Thr
225                 230                 235                 240 
Asn Arg Leu Ile Phe Glu Asp Lys Ala Thr Pro Cys Val Pro Asn Ala
                245                 250                 255     
Arg Arg Ile Lys Lys Lys Lys Ser Lys Pro Pro Glu Lys Ser Thr Ser
            260                 265                 270         
Pro Ser His Ala Val Val Ala Asn Val Gln Leu Val Leu His Leu Met
        275                 280                 285             
Lys Gln His Ser Lys Ala Leu Cys Asn Asp Arg Val Ile Asn Ser Ile
    290                 295                 300                 
Pro Leu Ala Lys Gln Val Ser Ser Arg Gly Gly Lys Ser Lys Lys Leu
305                 310                 315                 320 
Ser Val Thr Pro Pro Ser Ser Asn Gly Ile Asn Glu Glu Leu Ser Glu
                325                 330                 335     
Val Leu Gln Thr Leu Gln Asp Glu Phe Gly Gln Met Ser Phe Asp His
            340                 345                 350         
Gln Gln Leu Ala Lys Leu Ile Gln Glu Ser Pro Thr Val Glu Leu Lys
        355                 360                 365             
Asp Lys Leu Glu Cys Glu Leu Glu Ala Leu Val Gly Arg Met Glu Ala
    370                 375                 380                 
Lys Ala Asn Gln Ile Thr Lys Val Arg Lys Tyr Gln Ala Gln Leu Glu
385                 390                 395                 400 
Lys Gln Lys Leu Glu Lys Gln Lys Lys Glu Leu Lys Ala Thr Lys Lys
                405                 410                 415     
Thr Leu Asp Glu Glu Arg Asn Ser Ser Ser Arg Ser Gly Ile Thr Gly
            420                 425                 430         
Thr Thr Asn Lys Lys Asp Phe Met Lys Gln Arg Pro Gly Glu Lys Arg
        435                 440                 445             
Arg Lys Asn Leu Gln Leu Leu Lys Asp Met Gln Ser Ile Gln Asn Ser
    450                 455                 460                 
Leu Gln Ser Ser Ser Leu Cys Trp Asp Tyr
465                 470                 


<210> 6397
<211> 500
<212> PRT
<213> Homo sapiens

<400> 6397
Met Ala Ala Ala Ser Val Ser Ala Ala Ser Gly Ser His Leu Ser Asn
 1               5                  10                  15      
Ser Phe Ala Glu Pro Ser Arg Ser Asn Gly Ser Met Val Arg His Ser
            20                  25                  30          
Ser Ser Pro Tyr Val Val Tyr Pro Ser Asp Lys Pro Phe Leu Asn Ser
        35                  40                  45              
Asp Leu Arg Arg Ser Pro Ser Lys Pro Thr Leu Ala Tyr Pro Glu Ser
    50                  55                  60                  
Asn Ser Arg Ala Ile Phe Ser Ala Leu Lys Asn Leu Gln Asp Lys Ile
65                  70                  75                  80  
Arg Arg Leu Glu Leu Glu Arg Ile Gln Ala Glu Glu Ser Val Lys Thr
                85                  90                  95      
Leu Ser Arg Glu Thr Ile Glu Tyr Lys Lys Val Leu Asp Glu Gln Ile
            100                 105                 110         
Gln Glu Arg Glu Asn Ser Lys Asn Glu Glu Ser Lys His Asn Gln Glu
        115                 120                 125             
Leu Thr Ser Gln Leu Leu Ala Ala Glu Asn Lys Cys Asn Leu Leu Glu
    130                 135                 140                 
Lys Gln Leu Glu Tyr Met Arg Asn Met Ile Lys His Ala Glu Met Glu
145                 150                 155                 160 
Arg Thr Ser Val Leu Glu Lys Gln Val Ser Leu Glu Arg Glu Arg Gln
                165                 170                 175     
His Asp Gln Thr His Val Gln Ser Gln Leu Glu Lys Leu Asp Leu Leu
            180                 185                 190         
Glu Gln Glu Tyr Asn Lys Leu Thr Thr Met Gln Ala Leu Ala Glu Lys
        195                 200                 205             
Lys Met Gln Glu Leu Glu Ala Lys Leu His Glu Glu Glu Gln Glu Arg
    210                 215                 220                 
Lys Arg Met Gln Ala Lys Ala Ala Glu Leu Gln Thr Gly Leu Glu Thr
225                 230                 235                 240 
Asn Arg Leu Ile Phe Glu Asp Lys Ala Thr Pro Cys Val Pro Asn Ala
                245                 250                 255     
Arg Arg Ile Lys Lys Lys Lys Ser Lys Pro Pro Glu Lys Lys Ser Ser
            260                 265                 270         
Arg Asn Tyr Phe Gly Ala Gln Pro His Tyr Arg Leu Cys Leu Gly Asp
        275                 280                 285             
Met Pro Phe Val Ala Gly Lys Ser Thr Ser Pro Ser His Ala Val Val
    290                 295                 300                 
Ala Asn Val Gln Leu Val Leu His Leu Met Lys Gln His Ser Lys Ala
305                 310                 315                 320 
Leu Cys Asn Asp Arg Val Ile Asn Ser Ile Pro Leu Ala Lys Gln Val
                325                 330                 335     
Ser Ser Arg Gly Gly Lys Ser Lys Lys Leu Ser Val Thr Pro Pro Ser
            340                 345                 350         
Ser Asn Gly Ile Asn Glu Glu Leu Ser Glu Val Leu Gln Thr Leu Gln
        355                 360                 365             
Asp Glu Phe Gly Gln Met Ser Phe Asp His Gln Gln Leu Ala Lys Leu
    370                 375                 380                 
Ile Gln Glu Ser Pro Thr Val Glu Leu Lys Asp Lys Leu Glu Cys Glu
385                 390                 395                 400 
Leu Glu Ala Leu Val Gly Arg Met Glu Ala Lys Ala Asn Gln Ile Thr
                405                 410                 415     
Lys Val Arg Lys Tyr Gln Ala Gln Leu Glu Lys Gln Lys Leu Glu Lys
            420                 425                 430         
Gln Lys Lys Glu Leu Lys Ala Thr Lys Lys Thr Leu Asp Glu Glu Arg
        435                 440                 445             
Asn Ser Ser Ser Arg Ser Gly Ile Thr Gly Thr Thr Asn Lys Lys Asp
    450                 455                 460                 
Phe Met Lys Leu Arg Pro Gly Glu Lys Arg Arg Lys Asn Leu Gln Leu
465                 470                 475                 480 
Leu Lys Asp Met Gln Ser Ile Gln Asn Ser Leu Gln Ser Ser Ser Leu
                485                 490                 495     
Cys Trp Asp Tyr
            500 


<210> 6398
<211> 467
<212> PRT
<213> Homo sapiens

<400> 6398
Met Leu Gly Ile Trp Ile Val Ala Phe Leu Phe Phe Gly Thr Ser Arg
 1               5                  10                  15      
Gly Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Lys Asp Gly Leu
            20                  25                  30          
Pro Trp Thr Arg Thr Phe Ser Thr Glu Leu Val Gly Leu Pro Trp Ser
        35                  40                  45              
Pro Glu Lys Ile Asn Thr Arg Phe Leu Leu Tyr Thr Ile His Asn Pro
    50                  55                  60                  
Asn Ala Tyr Gln Glu Ile Ser Ala Val Asn Ser Ser Thr Ile Gln Ala
65                  70                  75                  80  
Ser Tyr Phe Gly Thr Asp Lys Ile Thr Arg Ile Asn Ile Ala Gly Trp
                85                  90                  95      
Lys Thr Asp Gly Lys Trp Gln Arg Asp Met Cys Asn Val Leu Leu Gln
            100                 105                 110         
Leu Glu Asp Ile Asn Cys Ile Asn Leu Asp Trp Ile Asn Gly Ser Arg
        115                 120                 125             
Glu Tyr Ile His Ala Val Asn Asn Leu Arg Val Val Gly Ala Glu Val
    130                 135                 140                 
Ala Tyr Phe Ile Asp Val Leu Met Lys Lys Phe Glu Tyr Ser Pro Ser
145                 150                 155                 160 
Lys Val His Leu Ile Gly His Ser Leu Gly Ala His Leu Ala Gly Glu
                165                 170                 175     
Ala Gly Ser Arg Ile Pro Gly Leu Gly Arg Ile Thr Gly Leu Asp Pro
            180                 185                 190         
Ala Gly Pro Phe Phe His Asn Thr Pro Lys Glu Val Arg Leu Asp Pro
        195                 200                 205             
Ser Asp Ala Asn Phe Val Asp Val Ile His Thr Asn Ala Ala Arg Ile
    210                 215                 220                 
Leu Phe Glu Leu Gly Val Gly Thr Ile Asp Ala Cys Gly His Leu Asp
225                 230                 235                 240 
Phe Tyr Pro Asn Gly Gly Lys His Met Pro Gly Cys Glu Asp Leu Ile
                245                 250                 255     
Thr Pro Leu Leu Lys Phe Asn Phe Asn Ala Tyr Lys Lys Glu Met Ala
            260                 265                 270         
Ser Phe Phe Asp Cys Asn His Ala Arg Ser Tyr Gln Phe Tyr Ala Glu
        275                 280                 285             
Ser Ile Leu Asn Pro Asp Ala Phe Ile Ala Tyr Pro Cys Arg Ser Tyr
    290                 295                 300                 
Thr Ser Phe Lys Ala Gly Asn Cys Phe Phe Cys Ser Lys Glu Gly Cys
305                 310                 315                 320 
Pro Thr Met Gly His Phe Ala Asp Arg Phe His Phe Lys Asn Met Lys
                325                 330                 335     
Thr Asn Gly Ser His Tyr Phe Leu Asn Thr Gly Ser Leu Ser Pro Phe
            340                 345                 350         
Ala Arg Trp Arg His Lys Leu Ser Val Lys Leu Ser Gly Ser Glu Val
        355                 360                 365             
Thr Gln Gly Thr Val Phe Leu Arg Val Gly Gly Ala Val Arg Lys Thr
    370                 375                 380                 
Gly Glu Phe Ala Ile Val Ser Gly Lys Leu Glu Pro Gly Met Thr Tyr
385                 390                 395                 400 
Thr Lys Leu Ile Asp Ala Asp Val Asn Val Gly Asn Ile Thr Ser Val
                405                 410                 415     
Gln Phe Ile Trp Lys Lys His Leu Phe Glu Asp Ser Gln Asn Lys Leu
            420                 425                 430         
Gly Ala Glu Met Val Ile Asn Thr Ser Gly Lys Tyr Gly Tyr Lys Ser
        435                 440                 445             
Thr Phe Cys Ser Gln Asp Ile Met Gly Pro Asn Ile Leu Gln Asn Leu
    450                 455                 460                 
Lys Pro Cys
465         


<210> 6399
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 6399
Glu Ile Arg Ser Trp Glu Lys Arg Lys Arg Leu Val Leu Cys Leu Leu
 1               5                  10                  15      
Glu Ala Ala Asp Met Lys Cys Phe Phe Pro Val Leu Ser Cys Leu Ala
            20                  25                  30          
Val Leu Gly Val Val Ser Ala Gln Arg Gln Val Thr Val Gln Glu Gly
        35                  40                  45              
Pro Leu Tyr Arg Thr Glu Gly Ser His Ile Thr Ile Trp Cys Asn Val
    50                  55                  60                  
Ser Gly Tyr Gln Gly Pro Ser Glu Gln Asn Phe Gln Trp Ser Ile Tyr
65                  70                  75                  80  
Leu Pro Ser Ser Pro Glu Arg Glu Val Gln Ile Val Ser Thr Met Asp
                85                  90                  95      
Ser Ser Phe Pro Tyr Ala Ile Tyr Thr Gln Arg Val Arg Gly Gly Lys
            100                 105                 110         
Ile Phe Ile Glu Arg Val Gln Gly Asn Ser Thr Leu Leu His Ile Thr
        115                 120                 125             
Asp Leu Gln Ala Arg Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Ser
    130                 135                 140                 
Thr Asp Lys Gln Tyr Phe Gly Ser Tyr Ser Ala Lys Met Asn Leu Val
145                 150                 155                 160 
Val Ile Pro Asp Ser Leu Gln Thr Thr Ala Met Pro Gln Thr Leu His
                165                 170                 175     
Arg Val Glu Gln Asp Pro Leu Glu Leu Thr Cys Glu Val Ala Ser Glu
            180                 185                 190         
Thr Ile Gln His Ser His Leu Ser Val Ala Trp Leu Arg Gln Lys Val
        195                 200                 205             
Gly Glu Lys Pro Val Glu Val Ile Ser Leu Ser Arg Asp Phe Met Leu
    210                 215                 220                 
His Ser Ser Ser Glu Tyr Ala Gln Arg Gln Ser Leu Gly Glu Val Arg
225                 230                 235                 240 
Leu Asp Lys Leu Gly Arg Thr Thr Phe Arg Leu Thr Ile Phe His Leu
                245                 250                 255     
Gln Pro Ser Asp Gln Gly Glu Phe Tyr Cys Glu Ala Ala Glu Trp Ile
            260                 265                 270         
Gln Asp Pro Asp Gly Ser Trp Tyr Ala Met Thr Arg Lys Arg Ser Glu
        275                 280                 285             
Gly Ala Val Val Asn Val Gln Pro Thr Asp Lys Glu Phe Thr Val Arg
    290                 295                 300                 
Leu Glu Thr Glu Lys Arg Leu His Thr Val Gly Glu Pro Val Glu Phe
305                 310                 315                 320 
Arg Cys Ile Leu Glu Ala Gln Asn Val Pro Asp Arg Tyr Phe Ala Val
                325                 330                 335     
Ser Trp Ala Phe Asn Ser Ser Leu Ile Ala Thr Met Gly Pro Asn Ala
            340                 345                 350         
Val Pro Val Leu Asn Ser Glu Phe Ala His Arg Glu Ala Arg Gly Gln
        355                 360                 365             
Leu Lys Val Ala Lys Glu Ser Asp Ser Val Phe Val Leu Lys Ile Tyr
    370                 375                 380                 
His Leu Arg Gln Glu Asp Ser Gly Lys Tyr Asn Cys Arg Val Thr Glu
385                 390                 395                 400 
Arg Glu Lys Thr Val Thr Gly Glu Phe Ile Asp Lys Glu Ser Lys Arg
                405                 410                 415     
Pro Lys Asn Ile Pro Ile Ile Val Leu Pro Leu Lys Ser Ser Ile Ser
            420                 425                 430         
Val Glu Val Ala Ser Asn Ala Ser Val Ile Leu Glu Gly Glu Asp Leu
        435                 440                 445             
Arg Phe Ser Cys Ser Val Arg Thr Ala Gly Arg Pro Gln Gly Arg Phe
    450                 455                 460                 
Ser Val Ile Trp Gln Leu Val Asp Arg Gln Asn Arg Arg Ser Asn Ile
465                 470                 475                 480 
Met Trp Leu Asp Arg Asp Gly Thr Val Gln Pro Gly Ser Ser Tyr Trp
                485                 490                 495     
Glu Arg Ser Ser Phe Gly Gly Val Gln Met Glu Gln Val Gln Pro Asn
            500                 505                 510         
Ser Phe Ser Leu Gly Ile Phe Asn Ser Arg Lys Glu Asp Glu Gly Gln
        515                 520                 525             
Tyr Glu Cys His Val Thr Glu Trp Val Arg Ala Val Asp Gly Glu Trp
    530                 535                 540                 
Gln Ile Val Gly Glu Arg Arg Ala Ser Thr Pro Ile Ser Ile Thr Ala
545                 550                 555                 560 
Leu Glu Met Gly Phe Ala Val Thr Ala Ile Ser Arg Thr Pro Gly Val
                565                 570                 575     
Thr Tyr Ser Asp Ser Phe Asp Leu Gln Cys Ile Ile Lys Pro His Tyr
            580                 585                 590         
Pro Ala Trp Val Pro Val Ser Val Thr Trp Arg Phe Gln Pro Val Gly
        595                 600                 605             
Thr Val Glu Phe His Asp Leu Val Thr Phe Thr Arg Asp Gly Gly Val
    610                 615                 620                 
Gln Trp Gly Asp Arg Ser Ser Ser Phe Arg Thr Arg Thr Ala Ile Glu
625                 630                 635                 640 
Lys Ala Glu Ser Ser Asn Asn Val Arg Leu Ser Ile Ser Arg Ala Ser
                645                 650                 655     
Asp Thr Glu Ala Gly Lys Tyr Gln Cys Val Ala Glu Leu Trp Arg Lys
            660                 665                 670         
Asn Tyr Asn Asn Thr Trp Thr Arg Leu Ala Glu Arg Thr Ser Asn Leu
        675                 680                 685             
Leu Glu Ile Arg Val Leu Gln Pro Val Thr Lys Leu Gln Val Ser Lys
    690                 695                 700                 
Ser Lys Arg Thr Leu Thr Leu Val Glu Asn Lys Pro Ile Gln Leu Asn
705                 710                 715                 720 
Cys Ser Val Lys Ser Gln Thr Ser Gln Asn Ser His Phe Ala Val Leu
                725                 730                 735     
Trp Tyr Val His Lys Pro Ser Asp Ala Asp Gly Lys Leu Ile Leu Lys
            740                 745                 750         
Thr Thr His Asn Ser Ala Phe Glu Tyr Gly Thr Tyr Ala Glu Glu Glu
        755                 760                 765             
Gly Leu Arg Ala Arg Leu Gln Phe Glu Arg His Val Ser Gly Gly Leu
    770                 775                 780                 
Phe Ser Leu Thr Val Gln Arg Ala Glu Val Ser Asp Ser Gly Ser Tyr
785                 790                 795                 800 
Tyr Cys His Val Glu Glu Trp Leu Leu Ser Pro Asn Tyr Ala Trp Tyr
                805                 810                 815     
Lys Leu Ala Glu Glu Val Ser Gly Arg Thr Glu Val Thr Val Lys Gln
            820                 825                 830         
Pro Asp Ser Arg Leu Arg Leu Ser Gln Ala Gln Gly Asn Leu Ser Val
        835                 840                 845             
Leu Glu Thr Arg Gln Val Gln Leu Glu Cys Val Val Leu Asn Arg Thr
    850                 855                 860                 
Ser Ile Thr Ser Gln Leu Met Val Glu Trp Phe Val Trp Lys Pro Asn
865                 870                 875                 880 
His Pro Glu Arg Glu Thr Val Ala Arg Leu Ser Arg Asp Ala Thr Phe
                885                 890                 895     
His Tyr Gly Glu Gln Ala Ala Lys Asn Asn Leu Lys Gly Arg Leu His
            900                 905                 910         
Leu Glu Ser Pro Ser Pro Gly Val Tyr Arg Leu Phe Ile Gln Asn Val
        915                 920                 925             
Ala Val Gln Asp Ser Gly Thr Tyr Ser Cys His Val Glu Glu Trp Leu
    930                 935                 940                 
Pro Ser Pro Ser Gly Met Trp Tyr Lys Arg Ala Glu Asp Thr Ala Gly
945                 950                 955                 960 
Gln Thr Ala Leu Thr Val Met Arg Pro Asp Ala Ser Leu Gln Val Asp
                965                 970                 975     
Thr Val Val Pro Asn Ala Thr Val Ser Glu Lys Ala Ala Phe Gln Leu
            980                 985                 990         
Asp Cys Ser Ile Val Ser Arg Ser Ser Gln Asp Ser Arg Phe Ala Val
        995                 1000                1005            
Ala Trp Tyr Ser Leu Arg Thr Lys Ala Gly Gly Lys Arg Ser Ser Pro
    1010                1015                1020                
Gly Leu Glu Glu Gln Glu Glu Glu Arg Glu Glu Glu Glu Glu Glu Asp
1025                1030                1035                1040
Asp Asp Asp Asp Asp Asp Pro Thr Glu Arg Thr Ala Leu Leu Ser Val
                1045                1050                1055    
Gly Pro Asp Ala Val Phe Gly Pro Glu Gly Ser Pro Trp Glu Gly Arg
            1060                1065                1070        
Leu Arg Phe Gln Arg Leu Ser Pro Val Leu Tyr Arg Leu Thr Val Leu
        1075                1080                1085            
Gln Ala Ser Pro Gln Asp Thr Gly Asn Tyr Ser Cys His Val Glu Glu
    1090                1095                1100                
Trp Leu Pro Ser Pro Gln Lys Glu Trp Tyr Arg Leu Thr Glu Glu Glu
1105                1110                1115                1120
Ser Ala Pro Ile Gly Ile Arg Val Leu Asp Thr Ser Pro Thr Leu Gln
                1125                1130                1135    
Ser Ile Ile Cys Ser Asn Asp Ala Leu Phe Tyr Phe Val Phe Phe Tyr
            1140                1145                1150        
Pro Phe Pro Ile Phe Gly Ile Leu Ile Ile Thr Ile Leu Leu Val Arg
        1155                1160                1165            
Phe Lys Ser Arg Asn Ser Ser Lys Asn Ser Asp Gly Lys Asn Gly Val
    1170                1175                1180                
Pro Leu Leu Trp Ile Lys Glu Pro His Leu Asn Tyr Ser Pro Thr Cys
1185                1190                1195                1200
Leu Glu Pro Pro Val Leu Ser Ile His Pro Gly Ala Ile Asp
                1205                1210                


<210> 6400
<211> 1215
<212> PRT
<213> Homo sapiens

<400> 6400
Met Lys Cys Phe Phe Pro Val Leu Ser Cys Leu Ala Val Leu Gly Val
 1               5                  10                  15      
Val Ser Ala Gln Arg Gln Val Thr Val Gln Glu Gly Pro Leu Tyr Arg
            20                  25                  30          
Thr Glu Gly Ser His Ile Thr Ile Trp Cys Asn Val Ser Gly Tyr Gln
        35                  40                  45              
Gly Pro Ser Glu Gln Asn Phe Gln Trp Ser Ile Tyr Leu Pro Ser Ser
    50                  55                  60                  
Pro Glu Arg Glu Val Gln Ile Val Ser Thr Met Asp Ser Ser Phe Pro
65                  70                  75                  80  
Tyr Ala Ile Tyr Thr Gln Arg Val Arg Gly Gly Lys Ile Phe Ile Glu
                85                  90                  95      
Arg Val Gln Gly Asn Ser Thr Leu Leu His Ile Thr Asp Leu Gln Ala
            100                 105                 110         
Arg Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Ser Thr Asp Lys Gln
        115                 120                 125             
Tyr Phe Gly Ser Tyr Ser Ala Lys Met Asn Leu Val Val Ile Pro Asp
    130                 135                 140                 
Ser Leu Gln Thr Thr Ala Met Pro Gln Thr Leu His Arg Val Glu Gln
145                 150                 155                 160 
Asp Pro Leu Glu Leu Thr Cys Glu Val Ala Ser Glu Thr Ile Gln His
                165                 170                 175     
Ser His Leu Ser Val Ala Trp Leu Arg Gln Lys Val Gly Glu Lys Pro
            180                 185                 190         
Val Glu Val Ile Ser Leu Ser Arg Asp Phe Met Leu His Ser Ser Ser
        195                 200                 205             
Glu Tyr Ala Gln Arg Gln Ser Leu Gly Glu Val Arg Leu Asp Lys Leu
    210                 215                 220                 
Gly Arg Thr Thr Phe Arg Leu Thr Ile Phe His Leu Gln Pro Ser Asp
225                 230                 235                 240 
Gln Gly Glu Phe Tyr Cys Glu Ala Ala Glu Trp Ile Gln Asp Pro Asp
                245                 250                 255     
Gly Ser Trp Tyr Ala Met Thr Arg Lys Arg Ser Glu Gly Ala Val Val
            260                 265                 270         
Asn Val Gln Pro Thr Asp Lys Glu Phe Thr Val Arg Leu Glu Thr Glu
        275                 280                 285             
Lys Arg Leu His Thr Val Gly Glu Pro Val Glu Phe Arg Cys Ile Leu
    290                 295                 300                 
Glu Ala Gln Asn Val Pro Asp Arg Tyr Phe Ala Val Ser Trp Ala Phe
305                 310                 315                 320 
Asn Ser Ser Leu Ile Ala Thr Met Gly Pro Asn Ala Val Pro Val Leu
                325                 330                 335     
Asn Ser Glu Phe Ala His Arg Glu Ala Arg Gly Gln Leu Lys Val Ala
            340                 345                 350         
Lys Glu Ser Asp Ser Val Phe Val Leu Lys Ile Tyr His Leu Arg Gln
        355                 360                 365             
Glu Asp Ser Gly Lys Tyr Asn Cys Arg Val Thr Glu Arg Glu Lys Thr
    370                 375                 380                 
Val Thr Gly Glu Phe Ile Asp Lys Glu Ser Lys Arg Pro Lys Asn Ile
385                 390                 395                 400 
Pro Ile Ile Val Leu Pro Leu Thr Asp Asn Trp Val Val Lys Val Pro
                405                 410                 415     
Gln His His Gln Leu Leu Ser Gln Gly His Leu Glu Ser Ser Ile Ser
            420                 425                 430         
Val Glu Val Ala Ser Asn Ala Ser Val Ile Leu Glu Gly Glu Asp Leu
        435                 440                 445             
Arg Phe Ser Cys Ser Val Arg Thr Ala Gly Arg Pro Gln Gly Arg Phe
    450                 455                 460                 
Ser Val Ile Trp Gln Leu Val Asp Arg Gln Asn Arg Arg Ser Asn Ile
465                 470                 475                 480 
Met Trp Leu Asp Arg Asp Gly Thr Val Gln Pro Gly Ser Ser Tyr Trp
                485                 490                 495     
Glu Arg Ser Ser Phe Gly Gly Val Gln Met Glu Gln Val Gln Pro Asn
            500                 505                 510         
Ser Phe Ser Leu Gly Ile Phe Asn Ser Arg Lys Glu Asp Glu Gly Gln
        515                 520                 525             
Tyr Glu Cys His Val Thr Glu Trp Val Arg Ala Val Asp Gly Glu Trp
    530                 535                 540                 
Gln Ile Val Gly Glu Arg Arg Ala Ser Thr Pro Ile Ser Ile Thr Ala
545                 550                 555                 560 
Leu Glu Met Gly Phe Ala Val Thr Ala Ile Ser Arg Thr Pro Gly Val
                565                 570                 575     
Thr Tyr Ser Asp Ser Phe Asp Leu Gln Cys Ile Ile Lys Pro His Tyr
            580                 585                 590         
Pro Ala Trp Val Pro Val Ser Val Thr Trp Arg Phe Gln Pro Val Gly
        595                 600                 605             
Thr Val Glu Phe His Asp Leu Val Thr Phe Thr Arg Asp Gly Gly Val
    610                 615                 620                 
Gln Trp Gly Asp Arg Ser Ser Ser Phe Arg Thr Arg Thr Ala Ile Glu
625                 630                 635                 640 
Lys Ala Glu Ser Ser Asn Asn Val Arg Leu Ser Ile Ser Arg Ala Ser
                645                 650                 655     
Asp Thr Glu Ala Gly Lys Tyr Gln Cys Val Ala Glu Leu Trp Arg Lys
            660                 665                 670         
Asn Tyr Asn Asn Thr Trp Thr Arg Leu Ala Glu Arg Thr Ser Asn Leu
        675                 680                 685             
Leu Glu Ile Arg Val Leu Gln Pro Val Thr Lys Leu Gln Val Ser Lys
    690                 695                 700                 
Ser Lys Arg Thr Leu Thr Leu Val Glu Asn Lys Pro Ile Gln Leu Asn
705                 710                 715                 720 
Cys Ser Val Lys Ser Gln Thr Ser Gln Asn Ser His Phe Ala Val Leu
                725                 730                 735     
Trp Tyr Val His Lys Pro Ser Asp Ala Asp Gly Lys Leu Ile Leu Lys
            740                 745                 750         
Thr Thr His Asn Ser Ala Phe Glu Tyr Gly Thr Tyr Ala Glu Glu Glu
        755                 760                 765             
Gly Leu Arg Ala Arg Leu Gln Phe Glu Arg His Val Ser Gly Gly Leu
    770                 775                 780                 
Phe Ser Leu Thr Val Gln Arg Ala Glu Val Ser Asp Ser Gly Ser Tyr
785                 790                 795                 800 
Tyr Cys His Val Glu Glu Trp Leu Leu Ser Pro Asn Tyr Ala Trp Tyr
                805                 810                 815     
Lys Leu Ala Glu Glu Val Ser Gly Arg Thr Glu Val Thr Val Lys Gln
            820                 825                 830         
Pro Asp Ser Arg Leu Arg Leu Ser Gln Ala Gln Gly Asn Leu Ser Val
        835                 840                 845             
Ser Gly Asp Pro Ala Gly Thr Ala Gly Val Cys Gly Ser Gln Pro His
    850                 855                 860                 
Gln His Asn Leu Pro Ala His Gly Gly Met Val Cys Met Glu Ala Gln
865                 870                 875                 880 
Pro Pro Glu Arg Glu Thr Val Ala Arg Leu Ser Arg Asp Ala Thr Phe
                885                 890                 895     
His Tyr Gly Glu Gln Ala Ala Lys Asn Asn Leu Lys Gly Arg Leu His
            900                 905                 910         
Leu Glu Ser Pro Ser Pro Gly Val Tyr Arg Leu Phe Ile Gln Asn Val
        915                 920                 925             
Ala Val Gln Asp Ser Gly Thr Tyr Ser Cys His Val Glu Glu Trp Leu
    930                 935                 940                 
Pro Ser Pro Ser Gly Met Trp Ser Lys Arg Ala Glu Asp Thr Ala Gly
945                 950                 955                 960 
Gln Thr Ala Leu Thr Val Met Arg Pro Asp Ala Ser Leu Gln Val Asp
                965                 970                 975     
Thr Val Val Pro Asn Ala Thr Val Ser Glu Lys Ala Ala Phe Gln Leu
            980                 985                 990         
Asp Cys Ser Ile Val Ser Arg Ser Ser Gln Asp Ser Arg Phe Ala Val
        995                 1000                1005            
Ala Trp Tyr Ser Leu Arg Thr Lys Ala Gly Gly Lys Arg Ser Ser Pro
    1010                1015                1020                
Gly Leu Glu Glu Gln Glu Glu Glu Arg Glu Glu Glu Glu Glu Glu Glu
1025                1030                1035                1040
Glu Asp Asp Asp Asp Asp Asp Pro Thr Glu Arg Thr Ala Leu Leu Ser
                1045                1050                1055    
Val Gly Pro Asp Ala Val Phe Gly Pro Glu Gly Asn Pro Trp Glu Gly
            1060                1065                1070        
Arg Leu Arg Phe Gln Arg Leu Ser Pro Val Leu Tyr Arg Leu Thr Val
        1075                1080                1085            
Leu Gln Ala Ser Pro Gln Asp Thr Gly Asn Tyr Ser Cys His Val Glu
    1090                1095                1100                
Glu Trp Leu Pro Ser Pro Gln Lys Glu Trp Tyr Arg Leu Thr Glu Glu
1105                1110                1115                1120
Glu Ser Ala Pro Ile Gly Ile Arg Val Leu Asp Thr Ser Pro Thr Leu
                1125                1130                1135    
Gln Ser Ile Ile Cys Ser Asn Asp Ala Leu Phe Tyr Phe Val Phe Phe
            1140                1145                1150        
Tyr Pro Phe Pro Ile Phe Gly Ile Leu Ile Ile Thr Ile Leu Leu Val
        1155                1160                1165            
Arg Phe Lys Ser Arg Asn Ser Ser Lys Asn Ser Asp Gly Lys Asn Gly
    1170                1175                1180                
Val Pro Leu Leu Trp Ile Lys Glu Pro His Leu Asn Tyr Ser Pro Thr
1185                1190                1195                1200
Cys Leu Glu Pro Pro Val Leu Ser Ile His Pro Gly Ala Ile Asp
                1205                1210                1215


<210> 6401
<211> 649
<212> PRT
<213> Homo sapiens

<400> 6401
Met Ile Ser Ala Ala Trp Ser Ile Phe Leu Ile Gly Thr Lys Ile Gly
 1               5                  10                  15      
Leu Phe Leu Gln Val Ala Pro Leu Ser Val Met Ala Lys Ser Cys Pro
            20                  25                  30          
Ser Val Cys Arg Cys Asp Ala Gly Phe Ile Tyr Cys Asn Asp Arg Phe
        35                  40                  45              
Leu Thr Ser Ile Pro Thr Gly Ile Pro Glu Asp Ala Thr Thr Leu Tyr
    50                  55                  60                  
Leu Gln Asn Asn Gln Ile Asn Asn Ala Gly Ile Pro Ser Asp Leu Lys
65                  70                  75                  80  
Asn Leu Leu Lys Val Glu Arg Ile Tyr Leu Tyr His Asn Ser Leu Asp
                85                  90                  95      
Glu Phe Pro Thr Asn Leu Pro Lys Tyr Val Lys Glu Leu His Leu Gln
            100                 105                 110         
Glu Asn Asn Ile Arg Thr Ile Thr Tyr Asp Ser Leu Ser Lys Ile Pro
        115                 120                 125             
Tyr Leu Glu Glu Leu His Leu Asp Asp Asn Ser Val Ser Ala Val Ser
    130                 135                 140                 
Ile Glu Glu Gly Ala Phe Arg Asp Ser Asn Tyr Leu Arg Leu Leu Phe
145                 150                 155                 160 
Leu Ser Arg Asn His Leu Ser Thr Ile Pro Trp Gly Leu Pro Arg Thr
                165                 170                 175     
Ile Glu Glu Leu Arg Leu Asp Asp Asn Arg Ile Ser Thr Ile Ser Ser
            180                 185                 190         
Pro Ser Leu Gln Gly Leu Thr Ser Leu Lys Arg Leu Val Leu Asp Gly
        195                 200                 205             
Asn Leu Leu Asn Asn His Gly Leu Gly Asp Lys Val Phe Phe Asn Leu
    210                 215                 220                 
Val Asn Leu Thr Glu Leu Ser Leu Val Arg Asn Ser Leu Thr Ala Ala
225                 230                 235                 240 
Pro Val Asn Leu Pro Gly Thr Asn Leu Arg Lys Leu Tyr Leu Gln Asp
                245                 250                 255     
Asn His Ile Asn Arg Val Pro Pro Asn Ala Phe Ser Tyr Leu Arg Gln
            260                 265                 270         
Leu Tyr Arg Leu Asp Met Ser Asn Asn Asn Leu Ser Asn Leu Pro Gln
        275                 280                 285             
Gly Ile Phe Asp Asp Leu Asp Asn Ile Thr Gln Leu Ile Leu Arg Asn
    290                 295                 300                 
Asn Pro Trp Tyr Cys Gly Cys Lys Met Lys Trp Val Arg Asp Trp Leu
305                 310                 315                 320 
Gln Ser Leu Pro Val Lys Val Asn Val Arg Gly Leu Met Cys Gln Ala
                325                 330                 335     
Pro Glu Lys Val Arg Gly Met Ala Ile Lys Asp Leu Asn Ala Glu Leu
            340                 345                 350         
Phe Asp Cys Lys Asp Ser Gly Ile Val Ser Thr Ile Gln Ile Thr Thr
        355                 360                 365             
Ala Ile Pro Asn Thr Val Tyr Pro Ala Gln Gly Gln Trp Pro Ala Pro
    370                 375                 380                 
Val Thr Lys Gln Pro Asp Ile Lys Asn Pro Lys Leu Thr Lys Asp His
385                 390                 395                 400 
Gln Thr Thr Gly Ser Pro Ser Arg Lys Thr Ile Thr Ile Thr Val Lys
                405                 410                 415     
Ser Val Thr Ser Asp Thr Ile His Ile Ser Trp Lys Leu Ala Leu Pro
            420                 425                 430         
Met Thr Ala Leu Arg Leu Ser Trp Leu Lys Leu Gly His Ser Pro Ala
        435                 440                 445             
Phe Gly Ser Ile Thr Glu Thr Ile Val Thr Gly Glu Arg Ser Glu Tyr
    450                 455                 460                 
Leu Val Thr Ala Leu Glu Pro Asp Ser Pro Tyr Lys Val Cys Met Val
465                 470                 475                 480 
Pro Met Glu Thr Ser Asn Leu Tyr Leu Phe Asp Glu Thr Pro Val Cys
                485                 490                 495     
Ile Glu Thr Glu Thr Ala Pro Leu Arg Met Tyr Asn Pro Thr Thr Thr
            500                 505                 510         
Leu Asn Arg Glu Gln Glu Lys Glu Pro Tyr Lys Asn Pro Asn Leu Pro
        515                 520                 525             
Leu Ala Ala Ile Ile Gly Gly Ala Val Ala Leu Val Thr Ile Ala Leu
    530                 535                 540                 
Leu Ala Leu Val Cys Trp Tyr Val His Arg Asn Gly Ser Leu Phe Ser
545                 550                 555                 560 
Arg Asn Cys Ala Tyr Ser Lys Gly Arg Arg Arg Lys Asp Asp Tyr Ala
                565                 570                 575     
Glu Ala Gly Thr Lys Lys Asp Asn Ser Ile Leu Glu Ile Arg Glu Thr
            580                 585                 590         
Ser Phe Gln Met Leu Pro Ile Ser Asn Glu Pro Ile Ser Lys Glu Glu
        595                 600                 605             
Phe Val Ile His Thr Ile Phe Pro Pro Asn Gly Met Asn Leu Tyr Lys
    610                 615                 620                 
Asn Asn His Ser Glu Ser Ser Ser Asn Arg Ser Tyr Arg Asp Ser Gly
625                 630                 635                 640 
Ile Pro Asp Ser Asp His Ser His Ser
                645                 


<210> 6402
<211> 3259
<212> PRT
<213> Homo sapiens

<400> 6402
Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu
 1               5                  10                  15      
Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro
            20                  25                  30          
Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu
        35                  40                  45              
Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu
    50                  55                  60                  
Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu
65                  70                  75                  80  
Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu
                85                  90                  95      
Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu
            100                 105                 110         
Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser
        115                 120                 125             
Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met
    130                 135                 140                 
Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile
145                 150                 155                 160 
Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala
                165                 170                 175     
Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu
            180                 185                 190         
Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln
        195                 200                 205             
Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala
    210                 215                 220                 
Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu
225                 230                 235                 240 
Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val
                245                 250                 255     
Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala
            260                 265                 270         
Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg
        275                 280                 285             
Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn
    290                 295                 300                 
Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu
305                 310                 315                 320 
Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His
                325                 330                 335     
Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala
            340                 345                 350         
Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln
        355                 360                 365             
Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu
    370                 375                 380                 
Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp
385                 390                 395                 400 
Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser
                405                 410                 415     
Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys
            420                 425                 430         
Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr
        435                 440                 445             
Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala
    450                 455                 460                 
Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu
465                 470                 475                 480 
Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu
                485                 490                 495     
Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu
            500                 505                 510         
Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser
        515                 520                 525             
Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly
    530                 535                 540                 
Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser
545                 550                 555                 560 
Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu
                565                 570                 575     
Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val
            580                 585                 590         
Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro
        595                 600                 605             
Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu
    610                 615                 620                 
Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala
625                 630                 635                 640 
Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp
                645                 650                 655     
Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu
            660                 665                 670         
Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg
        675                 680                 685             
Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln
    690                 695                 700                 
Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn
705                 710                 715                 720 
Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser
                725                 730                 735     
Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln
            740                 745                 750         
Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln
        755                 760                 765             
Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr
    770                 775                 780                 
Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser
785                 790                 795                 800 
Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln
                805                 810                 815     
Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu
            820                 825                 830         
Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu
        835                 840                 845             
Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu
    850                 855                 860                 
Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln
865                 870                 875                 880 
Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile
                885                 890                 895     
Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu
            900                 905                 910         
Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile
        915                 920                 925             
Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala
    930                 935                 940                 
Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys
945                 950                 955                 960 
Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu
                965                 970                 975     
Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys
            980                 985                 990         
Arg Lys Leu Gln Ala Ala Leu Ile Asn Arg Lys Glu Leu Leu Gln Arg
        995                 1000                1005            
Val Ser Arg Leu Glu Glu Glu Leu Ala Asn Leu Lys Asp Glu Ser Lys
    1010                1015                1020                
Lys Glu Ile Pro Leu Ser Glu Thr Glu Arg Gly Glu Val Glu Glu Asp
1025                1030                1035                1040
Lys Glu Asn Lys Glu Tyr Ser Glu Lys Cys Val Thr Ser Lys Cys Gln
                1045                1050                1055    
Glu Ile Glu Ile Tyr Leu Lys Gln Thr Ile Ser Glu Lys Glu Val Glu
            1060                1065                1070        
Leu Gln His Ile Arg Lys Asp Leu Glu Glu Lys Leu Ala Ala Glu Glu
        1075                1080                1085            
Gln Phe Gln Ala Leu Val Lys Gln Met Asn Gln Thr Leu Gln Asp Lys
    1090                1095                1100                
Thr Asn Gln Ile Asp Leu Leu Gln Ala Glu Ile Ser Glu Asn Gln Ala
1105                1110                1115                1120
Ile Ile Gln Lys Leu Ile Thr Ser Asn Thr Asp Ala Ser Asp Gly Asp
                1125                1130                1135    
Ser Val Ala Leu Val Lys Glu Thr Val Val Ile Ser Pro Pro Cys Thr
            1140                1145                1150        
Gly Ser Ser Glu His Trp Lys Pro Glu Leu Glu Glu Lys Ile Leu Ala
        1155                1160                1165            
Leu Glu Lys Glu Lys Glu Gln Leu Gln Lys Lys Leu Gln Glu Ala Leu
    1170                1175                1180                
Thr Ser Arg Lys Ala Ile Leu Lys Lys Ala Gln Glu Lys Glu Arg His
1185                1190                1195                1200
Leu Arg Glu Glu Leu Lys Gln Gln Lys Asp Asp Tyr Asn Arg Leu Gln
                1205                1210                1215    
Glu Gln Phe Asp Glu Gln Ser Lys Glu Asn Glu Asn Ile Gly Asp Gln
            1220                1225                1230        
Leu Arg Gln Leu Gln Ile Gln Val Arg Glu Ser Ile Asp Gly Lys Leu
        1235                1240                1245            
Pro Ser Thr Asp Gln Gln Glu Ser Cys Ser Ser Thr Pro Gly Leu Glu
    1250                1255                1260                
Glu Pro Leu Phe Lys Ala Thr Glu Gln His His Thr Gln Pro Val Leu
1265                1270                1275                1280
Glu Ser Asn Leu Cys Pro Asp Trp Pro Ser His Ser Glu Asp Ala Ser
                1285                1290                1295    
Ala Leu Gln Gly Gly Thr Ser Val Ala Gln Ile Lys Ala Gln Leu Lys
            1300                1305                1310        
Glu Ile Glu Ala Glu Lys Val Glu Leu Glu Leu Lys Val Ser Ser Thr
        1315                1320                1325            
Thr Ser Glu Leu Thr Lys Lys Ser Glu Glu Val Phe Gln Leu Gln Glu
    1330                1335                1340                
Gln Ile Asn Lys Gln Gly Leu Glu Ile Glu Ser Leu Lys Thr Val Ser
1345                1350                1355                1360
His Glu Ala Glu Val His Ala Glu Ser Leu Gln Gln Lys Leu Glu Ser
                1365                1370                1375    
Ser Gln Leu Gln Ile Ala Gly Leu Glu His Leu Arg Glu Leu Gln Pro
            1380                1385                1390        
Lys Leu Asp Glu Leu Gln Lys Leu Ile Ser Lys Lys Glu Glu Asp Val
        1395                1400                1405            
Ser Tyr Leu Ser Gly Gln Leu Ser Glu Lys Glu Ala Ala Leu Thr Lys
    1410                1415                1420                
Ile Gln Thr Glu Ile Ile Glu Gln Glu Asp Leu Ile Lys Ala Leu His
1425                1430                1435                1440
Thr Gln Leu Glu Met Gln Ala Lys Glu His Asp Glu Arg Ile Lys Gln
                1445                1450                1455    
Leu Gln Val Glu Leu Cys Glu Met Lys Gln Lys Pro Glu Glu Ile Gly
            1460                1465                1470        
Glu Glu Ser Arg Ala Lys Gln Gln Ile Gln Arg Lys Leu Gln Ala Ala
        1475                1480                1485            
Leu Ile Ser Arg Lys Glu Ala Leu Lys Glu Asn Lys Ser Leu Gln Glu
    1490                1495                1500                
Glu Leu Ser Leu Ala Arg Gly Thr Ile Glu Arg Leu Thr Lys Ser Leu
1505                1510                1515                1520
Ala Asp Val Glu Ser Gln Val Ser Ala Gln Asn Lys Glu Lys Asp Thr
                1525                1530                1535    
Val Leu Gly Arg Leu Ala Leu Leu Gln Glu Glu Arg Asp Lys Leu Ile
            1540                1545                1550        
Thr Glu Met Asp Arg Ser Leu Leu Glu Asn Gln Ser Leu Ser Ser Ser
        1555                1560                1565            
Cys Glu Ser Leu Lys Leu Ala Leu Glu Gly Leu Thr Glu Asp Lys Glu
    1570                1575                1580                
Lys Leu Val Lys Glu Ile Glu Ser Leu Lys Ser Ser Lys Ile Ala Glu
1585                1590                1595                1600
Ser Thr Glu Trp Gln Glu Lys His Lys Glu Leu Gln Lys Glu Tyr Glu
                1605                1610                1615    
Ile Leu Leu Gln Ser Tyr Glu Asn Val Ser Asn Glu Ala Glu Arg Ile
            1620                1625                1630        
Gln His Val Val Glu Ala Val Arg Gln Glu Lys Gln Glu Leu Tyr Gly
        1635                1640                1645            
Lys Leu Arg Ser Thr Glu Ala Asn Lys Lys Glu Thr Glu Lys Gln Leu
    1650                1655                1660                
Gln Glu Ala Glu Gln Glu Met Glu Glu Met Lys Glu Lys Met Arg Lys
1665                1670                1675                1680
Phe Ala Lys Ser Lys Gln Gln Lys Ile Leu Glu Leu Glu Glu Glu Asn
                1685                1690                1695    
Asp Arg Leu Arg Ala Glu Val His Pro Ala Gly Asp Thr Ala Lys Glu
            1700                1705                1710        
Cys Met Glu Thr Leu Leu Ser Ser Asn Ala Ser Met Lys Glu Glu Leu
        1715                1720                1725            
Glu Arg Val Lys Met Glu Tyr Glu Thr Leu Ser Lys Lys Phe Gln Ser
    1730                1735                1740                
Leu Met Ser Glu Lys Asp Ser Leu Ser Glu Glu Val Gln Asp Leu Lys
1745                1750                1755                1760
His Gln Ile Glu Asp Asn Val Ser Lys Gln Ala Asn Leu Glu Ala Thr
                1765                1770                1775    
Glu Lys His Asp Asn Gln Thr Asn Val Thr Glu Glu Gly Thr Gln Ser
            1780                1785                1790        
Ile Pro Gly Glu Thr Glu Glu Gln Asp Ser Leu Ser Met Ser Thr Arg
        1795                1800                1805            
Pro Thr Cys Ser Glu Ser Val Pro Ser Ala Lys Ser Ala Asn Pro Ala
    1810                1815                1820                
Val Ser Lys Asp Phe Ser Ser His Asp Glu Ile Asn Asn Tyr Leu Gln
1825                1830                1835                1840
Gln Ile Asp Gln Leu Lys Glu Arg Ile Ala Gly Leu Glu Glu Glu Lys
                1845                1850                1855    
Gln Lys Asn Lys Glu Phe Ser Gln Thr Leu Glu Asn Glu Lys Asn Thr
            1860                1865                1870        
Leu Leu Ser Gln Ile Ser Thr Lys Asp Gly Glu Leu Lys Met Leu Gln
        1875                1880                1885            
Glu Glu Val Thr Lys Met Asn Leu Leu Asn Gln Gln Ile Gln Glu Glu
    1890                1895                1900                
Leu Ser Arg Val Thr Lys Leu Lys Glu Thr Ala Glu Glu Glu Lys Asp
1905                1910                1915                1920
Asp Leu Glu Glu Arg Leu Met Asn Gln Leu Ala Glu Leu Asn Gly Ser
                1925                1930                1935    
Ile Gly Asn Tyr Cys Gln Asp Val Thr Asp Ala Gln Ile Lys Asn Glu
            1940                1945                1950        
Leu Leu Glu Ser Glu Met Lys Asn Leu Lys Lys Cys Val Ser Glu Leu
        1955                1960                1965            
Glu Glu Glu Lys Gln Gln Leu Val Lys Glu Lys Thr Lys Val Glu Ser
    1970                1975                1980                
Glu Ile Arg Lys Glu Tyr Leu Glu Lys Ile Gln Gly Ala Gln Lys Glu
1985                1990                1995                2000
Pro Gly Asn Lys Ser His Ala Lys Glu Leu Gln Glu Leu Leu Lys Glu
                2005                2010                2015    
Lys Gln Gln Glu Val Lys Gln Leu Gln Lys Asp Cys Ile Arg Tyr Gln
            2020                2025                2030        
Glu Lys Ile Ser Ala Leu Glu Arg Thr Val Lys Ala Leu Glu Phe Val
        2035                2040                2045            
Gln Thr Glu Ser Gln Lys Asp Leu Glu Ile Thr Lys Glu Asn Leu Ala
    2050                2055                2060                
Gln Ala Val Glu His Arg Lys Lys Ala Gln Ala Glu Leu Ala Ser Phe
2065                2070                2075                2080
Lys Val Leu Leu Asp Asp Thr Gln Ser Glu Ala Ala Arg Val Leu Ala
                2085                2090                2095    
Asp Asn Leu Lys Leu Lys Lys Glu Leu Gln Ser Asn Lys Glu Ser Val
            2100                2105                2110        
Lys Ser Gln Met Lys Gln Lys Asp Glu Asp Leu Glu Arg Arg Leu Glu
        2115                2120                2125            
Gln Ala Glu Glu Lys His Leu Lys Glu Lys Lys Asn Met Gln Glu Lys
    2130                2135                2140                
Leu Asp Ala Leu Arg Arg Glu Lys Val His Leu Glu Glu Thr Ile Gly
2145                2150                2155                2160
Glu Ile Gln Val Thr Leu Asn Lys Lys Asp Lys Glu Val Gln Gln Leu
                2165                2170                2175    
Gln Glu Asn Leu Asp Ser Thr Val Thr Gln Leu Ala Ala Phe Thr Lys
            2180                2185                2190        
Ser Met Ser Ser Leu Gln Asp Asp Arg Asp Arg Val Ile Asp Glu Ala
        2195                2200                2205            
Lys Lys Trp Glu Arg Lys Phe Ser Asp Ala Ile Gln Ser Lys Glu Glu
    2210                2215                2220                
Glu Ile Arg Leu Lys Glu Asp Asn Cys Ser Val Leu Lys Asp Gln Leu
2225                2230                2235                2240
Arg Gln Met Ser Ile His Met Glu Glu Leu Lys Ile Asn Ile Ser Arg
                2245                2250                2255    
Leu Glu His Asp Lys Gln Ile Trp Glu Ser Lys Ala Gln Thr Glu Val
            2260                2265                2270        
Gln Leu Gln Gln Lys Val Cys Asp Thr Leu Gln Gly Glu Asn Lys Glu
        2275                2280                2285            
Leu Leu Ser Gln Leu Glu Glu Thr Arg His Leu Tyr His Ser Ser Gln
    2290                2295                2300                
Asn Glu Leu Ala Lys Leu Glu Ser Glu Leu Lys Ser Leu Lys Asp Gln
2305                2310                2315                2320
Leu Thr Asp Leu Ser Asn Ser Leu Glu Lys Cys Lys Glu Gln Lys Gly
                2325                2330                2335    
Asn Leu Glu Gly Ile Ile Arg Gln Gln Glu Ala Asp Ile Gln Asn Ser
            2340                2345                2350        
Lys Phe Ser Tyr Glu Gln Leu Glu Thr Asp Leu Gln Ala Ser Arg Glu
        2355                2360                2365            
Leu Thr Ser Arg Leu His Glu Glu Ile Asn Met Lys Glu Gln Lys Ile
    2370                2375                2380                
Ile Ser Leu Leu Ser Gly Lys Glu Glu Ala Ile Gln Val Ala Ile Ala
2385                2390                2395                2400
Glu Leu Arg Gln Gln His Asp Lys Glu Ile Lys Glu Leu Glu Asn Leu
                2405                2410                2415    
Leu Ser Gln Glu Glu Glu Glu Asn Ile Val Leu Glu Glu Glu Asn Lys
            2420                2425                2430        
Lys Ala Val Asp Lys Thr Asn Gln Leu Met Glu Thr Leu Lys Thr Ile
        2435                2440                2445            
Lys Lys Glu Asn Ile Gln Gln Lys Ala Gln Leu Asp Ser Phe Val Lys
    2450                2455                2460                
Ser Met Ser Ser Leu Gln Asn Asp Arg Asp Arg Ile Val Gly Asp Tyr
2465                2470                2475                2480
Gln Gln Leu Glu Glu Arg His Leu Ser Ile Ile Leu Glu Lys Asp Gln
                2485                2490                2495    
Leu Ile Gln Glu Ala Ala Ala Glu Asn Asn Lys Leu Lys Glu Glu Ile
            2500                2505                2510        
Arg Gly Leu Arg Ser His Met Asp Asp Leu Asn Ser Glu Asn Ala Lys
        2515                2520                2525            
Leu Asp Ala Glu Leu Ile Gln Tyr Arg Glu Asp Leu Asn Gln Val Ile
    2530                2535                2540                
Thr Ile Lys Asp Ser Gln Gln Lys Gln Leu Leu Glu Val Gln Leu Gln
2545                2550                2555                2560
Gln Asn Lys Glu Leu Glu Asn Lys Tyr Ala Lys Leu Glu Glu Lys Leu
                2565                2570                2575    
Lys Glu Ser Glu Glu Ala Asn Glu Asp Leu Arg Arg Ser Phe Asn Ala
            2580                2585                2590        
Leu Gln Glu Glu Lys Gln Asp Leu Ser Lys Glu Ile Glu Ser Leu Lys
        2595                2600                2605            
Val Ser Ile Ser Gln Leu Thr Arg Gln Val Thr Ala Leu Gln Glu Glu
    2610                2615                2620                
Gly Thr Leu Gly Leu Tyr His Ala Gln Leu Lys Val Lys Glu Glu Glu
2625                2630                2635                2640
Val His Arg Leu Ser Ala Leu Phe Ser Ser Ser Gln Lys Arg Ile Ala
                2645                2650                2655    
Glu Leu Glu Glu Glu Leu Val Cys Val Gln Lys Glu Ala Ala Lys Lys
            2660                2665                2670        
Val Gly Glu Ile Glu Asp Lys Leu Lys Lys Glu Leu Lys His Leu His
        2675                2680                2685            
His Asp Ala Gly Ile Met Arg Asn Glu Thr Glu Thr Ala Glu Glu Arg
    2690                2695                2700                
Val Ala Glu Leu Ala Arg Asp Leu Val Glu Met Glu Gln Lys Leu Leu
2705                2710                2715                2720
Met Val Thr Lys Glu Asn Lys Gly Leu Thr Ala Gln Ile Gln Ser Phe
                2725                2730                2735    
Gly Arg Ser Met Ser Ser Leu Gln Asn Ser Arg Asp His Ala Asn Glu
            2740                2745                2750        
Glu Leu Asp Glu Leu Lys Arg Lys Tyr Asp Ala Ser Leu Lys Glu Leu
        2755                2760                2765            
Ala Gln Leu Lys Glu Gln Gly Leu Leu Asn Arg Glu Arg Asp Ala Leu
    2770                2775                2780                
Leu Ser Glu Thr Ala Phe Ser Met Asn Ser Thr Glu Glu Asn Ser Leu
2785                2790                2795                2800
Ser His Leu Glu Lys Leu Asn Gln Gln Leu Leu Ser Lys Asp Glu Gln
                2805                2810                2815    
Leu Leu His Leu Ser Ser Gln Leu Glu Asp Ser Tyr Asn Gln Val Gln
            2820                2825                2830        
Ser Phe Ser Lys Ala Met Ala Ser Leu Gln Asn Glu Arg Asp His Leu
        2835                2840                2845            
Trp Asn Glu Leu Glu Lys Phe Arg Lys Ser Glu Glu Gly Lys Gln Arg
    2850                2855                2860                
Ser Ala Ala Gln Pro Ser Thr Ser Pro Ala Glu Val Gln Ser Leu Lys
2865                2870                2875                2880
Lys Ala Met Ser Ser Leu Gln Asn Asp Arg Asp Arg Leu Leu Lys Glu
                2885                2890                2895    
Leu Lys Asn Leu Gln Gln Gln Tyr Leu Gln Ile Asn Gln Glu Ile Thr
            2900                2905                2910        
Glu Leu His Pro Leu Lys Ala Gln Leu Gln Glu Tyr Gln Asp Lys Thr
        2915                2920                2925            
Lys Ala Phe Gln Ile Met Gln Glu Glu Leu Arg Gln Glu Asn Leu Ser
    2930                2935                2940                
Trp Gln His Glu Leu His Gln Leu Arg Met Glu Lys Ser Ser Trp Glu
2945                2950                2955                2960
Ile His Glu Arg Arg Met Lys Glu Gln Tyr Leu Met Ala Ile Ser Asp
                2965                2970                2975    
Lys Asp Gln Gln Leu Ser His Leu Gln Asn Leu Ile Arg Glu Leu Arg
            2980                2985                2990        
Ser Ser Ser Ser Gln Thr Gln Pro Leu Lys Val Gln Tyr Gln Arg Gln
        2995                3000                3005            
Ala Ser Pro Glu Thr Ser Ala Ser Pro Asp Gly Ser Gln Asn Leu Val
    3010                3015                3020                
Tyr Glu Thr Glu Leu Leu Arg Thr Gln Leu Asn Asp Ser Leu Lys Glu
3025                3030                3035                3040
Ile His Gln Lys Glu Leu Arg Ile Gln Gln Leu Asn Ser Asn Phe Ser
                3045                3050                3055    
Gln Leu Leu Glu Glu Lys Asn Thr Leu Ser Ile Gln Leu Cys Asp Thr
            3060                3065                3070        
Ser Gln Ser Leu Arg Glu Asn Gln Gln His Tyr Gly Asp Leu Leu Asn
        3075                3080                3085            
His Cys Ala Val Leu Glu Lys Gln Val Gln Glu Leu Gln Ala Gly Pro
    3090                3095                3100                
Leu Asn Ile Asp Val Ala Pro Gly Ala Pro Gln Glu Lys Asn Gly Val
3105                3110                3115                3120
His Arg Lys Ser Asp Pro Glu Glu Leu Arg Glu Pro Gln Gln Ser Phe
                3125                3130                3135    
Ser Glu Ala Gln Gln Gln Leu Cys Asn Thr Arg Gln Glu Val Asn Glu
            3140                3145                3150        
Leu Arg Lys Leu Leu Glu Glu Glu Arg Asp Gln Arg Val Ala Ala Glu
        3155                3160                3165            
Asn Ala Leu Ser Val Ala Glu Glu Gln Ile Arg Arg Leu Glu His Ser
    3170                3175                3180                
Glu Trp Asp Ser Ser Arg Thr Pro Ile Ile Gly Ser Cys Gly Thr Gln
3185                3190                3195                3200
Glu Gln Ala Leu Leu Ile Asp Leu Thr Ser Asn Ser Cys Arg Arg Thr
                3205                3210                3215    
Arg Ser Gly Val Gly Trp Lys Arg Val Leu Arg Ser Leu Cys His Ser
            3220                3225                3230        
Arg Thr Arg Val Pro Leu Leu Ala Ala Ile Tyr Phe Leu Met Ile His
        3235                3240                3245            
Val Leu Leu Ile Leu Cys Phe Thr Gly His Leu
    3250                3255                


<210> 6403
<211> 228
<212> PRT
<213> Homo sapiens

<400> 6403
Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln
 1               5                  10                  15      
Leu Thr Glu His Leu Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser
            20                  25                  30          
Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr Cys Cys Met Glu His
        35                  40                  45              
Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala
    50                  55                  60                  
Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly
65                  70                  75                  80  
Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg
                85                  90                  95      
Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala
            100                 105                 110         
Asp Asp Pro Asp Ser Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro
        115                 120                 125             
Leu Leu Leu Ser Leu Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys
    130                 135                 140                 
Arg Glu Arg Gln Glu Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile
145                 150                 155                 160 
Cys Arg Glu Thr Pro Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu
                165                 170                 175     
Tyr Asp Thr Ile Pro His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro
            180                 185                 190         
Ala Asn Thr Val Tyr Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn
        195                 200                 205             
Pro His Ser Leu Leu Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr
    210                 215                 220                 
Glu Asn Val Ile
225             


<210> 6404
<211> 335
<212> PRT
<213> Homo sapiens

<400> 6404
Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln
 1               5                  10                  15      
Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser
            20                  25                  30          
Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val
        35                  40                  45              
Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln
    50                  55                  60                  
Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg
65                  70                  75                  80  
Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys
                85                  90                  95      
Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu
            100                 105                 110         
Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu
        115                 120                 125             
Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr
    130                 135                 140                 
Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val
145                 150                 155                 160 
Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn
                165                 170                 175     
Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr
            180                 185                 190         
Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro
        195                 200                 205             
Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser
    210                 215                 220                 
Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu
225                 230                 235                 240 
Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu
                245                 250                 255     
Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro
            260                 265                 270         
Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro
        275                 280                 285             
His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr
    290                 295                 300                 
Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu
305                 310                 315                 320 
Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile
                325                 330                 335 


<210> 6405
<211> 1603
<212> PRT
<213> Homo sapiens

<400> 6405
Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala
 1               5                  10                  15      
Thr Phe Gly His Gly Ala Asn Thr Gly Ala Gln Cys Pro Pro Ser Gln
            20                  25                  30          
Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val
        35                  40                  45              
Thr Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Lys Ser Ala
    50                  55                  60                  
Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly
65                  70                  75                  80  
Ala Ala Pro Val Thr Gln Pro Thr Arg Arg Val Phe Pro Arg Gly Leu
                85                  90                  95      
Pro Glu Glu Phe Ala Leu Val Leu Thr Leu Leu Leu Lys Lys His Thr
            100                 105                 110         
His Gln Lys Thr Trp Tyr Leu Phe Gln Val Thr Asp Ala Asn Gly Tyr
        115                 120                 125             
Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu
    130                 135                 140                 
Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val
145                 150                 155                 160 
Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala
                165                 170                 175     
Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln
            180                 185                 190         
Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu
        195                 200                 205             
Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln
    210                 215                 220                 
Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys
225                 230                 235                 240 
Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Thr Ser Lys Ala Arg Arg
                245                 250                 255     
Asp Thr Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly
            260                 265                 270         
Lys Val Tyr Thr Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu
        275                 280                 285             
Val Asp Ala Gln Leu Thr Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly
    290                 295                 300                 
Ala Lys Val His Gln Glu Thr Ala Ala Asp Glu Cys Pro Pro Cys Val
305                 310                 315                 320 
His Gly Ala Arg Asp Ser Asn Val Thr Leu Ala Pro Ser Gly Pro Lys
                325                 330                 335     
Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly
            340                 345                 350         
Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala
        355                 360                 365             
Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly
    370                 375                 380                 
Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Thr Gly Glu Lys Gly Gln
385                 390                 395                 400 
Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro
                405                 410                 415     
Gly Arg Asp Ala Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly Gln
            420                 425                 430         
Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu Pro
        435                 440                 445             
Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly Thr
    450                 455                 460                 
Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly Ser
465                 470                 475                 480 
Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys Pro
                485                 490                 495     
Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Thr Leu
            500                 505                 510         
Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly Pro
        515                 520                 525             
Lys Gly Glu Pro Gly Asp Pro Val Arg Ala Arg Gly Asp Pro Gly Ile
    530                 535                 540                 
Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser Ser
545                 550                 555                 560 
Val Val Gly Ala Gln His Leu Val Ser Ser Thr Gly Ala Ser Gly Asp
                565                 570                 575     
Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala Gly
            580                 585                 590         
Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly Pro
        595                 600                 605             
Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile Lys
    610                 615                 620                 
Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn Leu
625                 630                 635                 640 
Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly Glu
                645                 650                 655     
Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln Gly
            660                 665                 670         
Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly Asn
        675                 680                 685             
Pro Gly Asp Pro Gly Thr Pro Gly Thr Thr Gly Arg Pro Gly Leu Ser
    690                 695                 700                 
Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys Gly
705                 710                 715                 720 
Asp Gly Cys Thr Ala Cys Pro Ser Leu Gln Gly Thr Val Thr Asp Met
                725                 730                 735     
Ala Gly Arg Pro Gly Gln Pro Gly Pro Lys Gly Glu Gln Gly Pro Glu
            740                 745                 750         
Gly Val Gly Arg Pro Gly Lys Pro Gly Gln Pro Gly Leu Pro Gly Val
        755                 760                 765             
Gln Gly Pro Pro Gly Leu Lys Gly Val Gln Gly Glu Pro Gly Pro Pro
    770                 775                 780                 
Gly Arg Gly Val Gln Gly Pro Gln Gly Glu Pro Gly Ala Pro Gly Leu
785                 790                 795                 800 
Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro Thr
                805                 810                 815     
Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly Val Lys Gly Ala Thr Gly
            820                 825                 830         
Pro Val Gly Pro Pro Gly Ala Ser Val Ser Gly Pro Pro Gly Arg Asp
        835                 840                 845             
Gly Gln Gln Gly Gln Thr Gly Leu Arg Gly Thr Pro Gly Glu Lys Gly
    850                 855                 860                 
Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu Cys Ser Cys Pro Ser Gln
865                 870                 875                 880 
Gly Asp Leu Ile Phe Ser Gly Met Pro Gly Ala Pro Gly Leu Trp Met
                885                 890                 895     
Gly Ser Ser Trp Gln Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly
            900                 905                 910         
Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Gln Gly Val Pro Gly Asn
        915                 920                 925             
Asn Gly Leu Pro Gly Gln Pro Gly Leu Thr Ala Glu Leu Gly Ser Leu
    930                 935                 940                 
Pro Ile Glu Gln His Leu Leu Lys Ser Ile Cys Gly Asp Cys Val Gln
945                 950                 955                 960 
Gly Gln Arg Ala His Pro Gly Tyr Leu Val Glu Lys Gly Glu Lys Gly
                965                 970                 975     
Asp Gln Gly Ile Pro Gly Val Pro Gly Leu Asp Asn Cys Ala Gln Cys
            980                 985                 990         
Phe Leu Ser Leu Glu Arg Pro Arg Ala Glu Glu Ala Arg Gly Asp Asn
        995                 1000                1005            
Ser Glu Gly Asp Pro Gly Cys Val Gly Ser Pro Gly Leu Pro Gly Pro
    1010                1015                1020                
Pro Gly Leu Pro Gly Gln Arg Gly Glu Glu Gly Pro Pro Gly Met Arg
1025                1030                1035                1040
Gly Ser Pro Gly Pro Pro Gly Pro Ile Gly Pro Pro Gly Phe Pro Gly
                1045                1050                1055    
Ala Val Gly Ser Pro Gly Leu Pro Gly Leu Gln Gly Glu Arg Gly Leu
            1060                1065                1070        
Thr Gly Leu Thr Gly Asp Lys Gly Glu Pro Gly Pro Pro Gly Gln Pro
        1075                1080                1085            
Gly Tyr Pro Gly Ala Thr Gly Pro Pro Gly Leu Pro Gly Ile Lys Gly
    1090                1095                1100                
Glu Arg Gly Tyr Thr Gly Ser Ala Gly Glu Lys Gly Glu Pro Gly Pro
1105                1110                1115                1120
Pro Gly Ser Glu Gly Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro Arg
                1125                1130                1135    
Gly Glu Arg Gly Pro Gln Gly Asn Ser Gly Glu Lys Gly Asp Gln Gly
            1140                1145                1150        
Phe Gln Gly Gln Pro Gly Phe Thr Gly Pro Thr Gly Ser Pro Gly Phe
        1155                1160                1165            
Pro Gly Lys Val Gly Ser Pro Gly Pro Pro Gly Pro Gln Ala Glu Lys
    1170                1175                1180                
Gly Ser Glu Gly Ile Arg Gly Pro Ser Gly Leu Pro Gly Ser Pro Gly
1185                1190                1195                1200
Pro Pro Gly Pro Pro Gly Ile Gln Gly Pro Ala Gly Leu Asp Gly Leu
                1205                1210                1215    
Asp Gly Lys Asp Gly Lys Pro Gly Leu Arg Gly Asp Pro Gly Pro Ala
            1220                1225                1230        
Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Phe Lys Gly Lys Thr Gly
        1235                1240                1245            
His Pro Gly Leu Pro Gly Pro Lys Gly Asp Cys Gly Lys Pro Gly Pro
    1250                1255                1260                
Pro Gly Ser Thr Gly Arg Pro Gly Ala Glu Gly Glu Pro Gly Ala Met
1265                1270                1275                1280
Gly Pro Gln Gly Arg Pro Gly Pro Pro Gly His Val Gly Pro Pro Gly
                1285                1290                1295    
Pro Pro Gly Gln Pro Gly Pro Ala Gly Ile Ser Ala Val Gly Leu Lys
            1300                1305                1310        
Gly Asp Arg Gly Ala Thr Gly Glu Arg Gly Leu Ala Gly Leu Pro Gly
        1315                1320                1325            
Gln Pro Gly Pro Pro Gly His Pro Gly Pro Pro Gly Glu Pro Gly Thr
    1330                1335                1340                
Asp Gly Ala Ala Gly Lys Glu Gly Pro Pro Gly Lys Gln Gly Phe Tyr
1345                1350                1355                1360
Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Ala Gly Gln Lys Gly
                1365                1370                1375    
Gln Ala Gly Glu Lys Gly Arg Ala Gly Met Pro Gly Gly Pro Gly Lys
            1380                1385                1390        
Ser Gly Ser Met Gly Pro Val Gly Pro Pro Gly Pro Ala Gly Glu Arg
        1395                1400                1405            
Gly His Pro Gly Ala Pro Gly Pro Ser Gly Ser Pro Gly Leu Pro Gly
    1410                1415                1420                
Val Pro Gly Ser Met Gly Asp Met Val Asn Tyr Asp Glu Ile Lys Arg
1425                1430                1435                1440
Phe Ile Arg Gln Glu Ile Ile Lys Met Phe Asp Glu Arg Met Ala Tyr
                1445                1450                1455    
Tyr Thr Ser Arg Met Gln Phe Pro Met Glu Met Ala Ala Ala Pro Gly
            1460                1465                1470        
Arg Pro Gly Pro Pro Gly Lys Asp Gly Ala Pro Gly Arg Pro Gly Ala
        1475                1480                1485            
Pro Gly Ser Pro Gly Leu Pro Gly Gln Ile Gly Arg Glu Gly Arg Gln
    1490                1495                1500                
Gly Leu Pro Gly Val Arg Gly Leu Pro Gly Thr Lys Gly Glu Lys Gly
1505                1510                1515                1520
Asp Ile Gly Ile Gly Ile Ala Gly Glu Asn Gly Leu Pro Gly Pro Pro
                1525                1530                1535    
Gly Pro Gln Gly Pro Pro Gly Tyr Gly Lys Met Gly Ala Thr Gly Pro
            1540                1545                1550        
Met Gly Gln Gln Gly Ile Pro Gly Ile Pro Gly Pro Pro Gly Pro Met
        1555                1560                1565            
Gly Gln Pro Gly Lys Ala Gly His Cys Asn Pro Ser Asp Cys Phe Gly
    1570                1575                1580                
Ala Met Pro Met Glu Gln Gln Tyr Pro Pro Met Lys Thr Met Lys Gly
1585                1590                1595                1600
Pro Phe Gly
            


<210> 6406
<211> 638
<212> PRT
<213> Homo sapiens

<400> 6406
Met Gly Arg Tyr Ser Ala Val Gly Ser Val Thr Glu Arg Ile Phe Thr
 1               5                  10                  15      
Leu Tyr Tyr Asp His Leu Gly Phe Leu His Lys Leu Thr Leu Gly Arg
            20                  25                  30          
Phe Glu Ala Ser Gly Pro Pro Thr Ala Phe Gly Asn Ser Arg Asn Leu
        35                  40                  45              
Phe Gly Gln Pro Pro Asp Met Gly Phe Glu Thr Ala Leu Ala Pro Gln
    50                  55                  60                  
His Thr Ser Leu Asp Glu Ile Ile Phe Phe Ala Tyr Val Pro Glu Asn
65                  70                  75                  80  
Glu Pro Gln Glu Thr Ile Tyr Ser Lys Lys Phe Gly Asn Ile His Tyr
                85                  90                  95      
Gly Lys Val Ile His Ser Gly Lys Thr Gly Arg Ala Tyr Ile Arg Lys
            100                 105                 110         
Val Leu Gln His Thr Thr Pro Lys Gly Phe Leu Ser Ser Val Ile Ala
        115                 120                 125             
Glu Met Lys Glu Pro Phe Gly Leu Glu Glu Val Asn Glu Ser Ser Cys
    130                 135                 140                 
Leu Ser Ser Ser Leu Leu Ile Asn Lys Ala Gly Asn Val Tyr Lys Leu
145                 150                 155                 160 
Thr Leu Asp Ser Gln Val Val Gln Ala Leu Phe Glu Asp Thr Asp Ile
                165                 170                 175     
Glu Lys Thr Val Val Leu Pro Gly Tyr Ser Ser Phe Leu Ile Thr Ser
            180                 185                 190         
Ile Leu Asp Asn Lys Asn Ala Leu Ala Ile Ala Thr Met Pro Glu Ser
        195                 200                 205             
Ala Pro Asn Asn Met Thr Phe Leu Lys Ser Thr Trp Phe Leu Tyr Asn
    210                 215                 220                 
Phe Gly Gln Arg Asn Gly Arg Thr Trp Lys Ile Tyr Ser Lys Pro Cys
225                 230                 235                 240 
Asn Tyr Trp Phe Gln His Asp Asp Ser Pro Ser Leu Asn Ile Val Lys
                245                 250                 255     
Tyr Ile Asp Leu Gly Asn Ser Tyr Val Leu Lys Ala Lys Val Ile Arg
            260                 265                 270         
Asn Ala Lys Gly Phe Arg Met Leu Glu Ile Pro Leu Leu Thr Val Phe
        275                 280                 285             
Val Gly Asn Pro Asn Leu Leu Glu Val Thr Ala Glu Val Thr Phe Asp
    290                 295                 300                 
Asp Thr Asp Ser Tyr Val Ile Thr Ile Ser Ala Ala Ser Lys Val Leu
305                 310                 315                 320 
His Gln Gly Ser Thr Ser Leu Ala Phe Ile Met Trp Ser Ala Ser Thr
                325                 330                 335     
Glu Cys Phe Val Thr Thr Met Val Pro Thr Leu Lys Ser Ser Cys Ser
            340                 345                 350         
Tyr Leu Arg Ser Met His His Ile Pro Ser Lys Phe Ile Pro Phe Glu
        355                 360                 365             
Asp Trp Ile Ser Gly Val His Lys Asp Ser Gln Gly Phe Asn Leu Ile
    370                 375                 380                 
Lys Thr Leu Pro Ile Asn Tyr Arg Pro Pro Ser Asn Met Gly Ile Ala
385                 390                 395                 400 
Ile Pro Leu Thr Asp Asn Phe Tyr His Ala Asp Pro Ser Lys Pro Ile
                405                 410                 415     
Pro Arg Asn Met Phe His Met Ser Lys Lys Thr Gly Lys Phe Lys Gln
            420                 425                 430         
Cys Ala Asn Val Ser Thr Arg Glu Glu Cys Asn Cys Thr Lys Asp Gln
        435                 440                 445             
Lys Phe Ser His Ala Val Ala Phe Ser Asp Cys Arg Glu Lys Val Pro
    450                 455                 460                 
Arg Phe Lys Phe Pro Ile Thr Gln Tyr Pro Val Ser Leu Glu Ile Ile
465                 470                 475                 480 
Asn Glu Asp Gly Arg Val Pro Leu Gln Ser Pro Tyr Leu Val Thr Val
                485                 490                 495     
Thr Glu Val Asn Met Arg His Asn Trp Lys Leu Lys His Thr Val Pro
            500                 505                 510         
Glu Asn Ile Lys Arg Met Lys Gln Leu Val Glu Pro Ile Leu Gly Ala
        515                 520                 525             
Ala Val Tyr Asn Pro Ser Gly Leu Asn Leu Ser Ile Lys Gly Ser Glu
    530                 535                 540                 
Leu Phe His Phe Arg Val Thr Val Ile Ser Gly Val Thr Phe Cys Asn
545                 550                 555                 560 
Leu Ile Glu Glu Phe Gln Ile Tyr Val Asp Glu Ala Pro Leu Pro Phe
                565                 570                 575     
Pro Gly His Thr Leu Ile Ala Val Ala Thr Ala Val Val Leu Gly Gly
            580                 585                 590         
Leu Ile Phe Ile Ala Phe Met Phe Gln Leu Gln Gly Ile His Pro Trp
        595                 600                 605             
Arg Thr Phe Gln Arg Trp Ile Arg Arg Asn Gln Glu Lys Phe Ser Ser
    610                 615                 620                 
Ile Ser Leu Ser Glu Leu Ile His Arg Ser Lys Ser Glu Glu
625                 630                 635             


<210> 6407
<211> 906
<212> PRT
<213> Homo sapiens

<400> 6407
Met Glu His Gly Thr Leu Leu Ala Gln Pro Gly Leu Trp Thr Arg Asp
 1               5                  10                  15      
Thr Ser Trp Ala Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr
            20                  25                  30          
Ala Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn
        35                  40                  45              
Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser
    50                  55                  60                  
Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp
65                  70                  75                  80  
Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala
                85                  90                  95      
Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His
            100                 105                 110         
Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val
        115                 120                 125             
Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Asn Lys Asp
    130                 135                 140                 
Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala
145                 150                 155                 160 
Ile Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val
                165                 170                 175     
Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala
            180                 185                 190         
Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Ser Gly
        195                 200                 205             
Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Gly Lys Glu
    210                 215                 220                 
Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu
225                 230                 235                 240 
Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe
                245                 250                 255     
Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr
            260                 265                 270         
Ser Gly Val Asn Met Thr Gly Phe Arg Leu Leu Asn Ile Asp Asn Pro
        275                 280                 285             
His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala
    290                 295                 300                 
Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu
305                 310                 315                 320 
Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His
                325                 330                 335     
Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys
            340                 345                 350         
Pro Trp Arg Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Ser
        355                 360                 365             
Arg Trp Asp Gly Leu Thr Gly His Ile Thr Phe Asn Lys Thr Asn Gly
    370                 375                 380                 
Leu Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly
385                 390                 395                 400 
Thr Glu Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr
                405                 410                 415     
Asp Ser Asn Lys Asp Lys Ser Ser Asn Ile Thr Asp Ser Leu Ala Asn
            420                 425                 430         
Arg Thr Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr
        435                 440                 445             
Arg Lys Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr
    450                 455                 460                 
Cys Leu Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Ile Tyr
465                 470                 475                 480 
Asp Val Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys
                485                 490                 495     
Gly Glu Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp
            500                 505                 510         
Leu Ala Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile
        515                 520                 525             
Asp Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg
    530                 535                 540                 
Lys Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu
545                 550                 555                 560 
Ser Pro Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser
                565                 570                 575     
Cys Val Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn
            580                 585                 590         
Pro His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr
        595                 600                 605             
Leu Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly
    610                 615                 620                 
Ser Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile
625                 630                 635                 640 
Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu
                645                 650                 655     
Ala Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala
            660                 665                 670         
Asp Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp
        675                 680                 685             
Gly Ser Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu
    690                 695                 700                 
Lys Met Trp Ala Phe Met Ser Ser Arg Gln Gln Thr Ala Leu Val Arg
705                 710                 715                 720 
Asn Ser Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu
                725                 730                 735     
Leu Met Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn
            740                 745                 750         
Leu Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly
        755                 760                 765             
Thr Pro Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu
    770                 775                 780                 
Gln Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp
785                 790                 795                 800 
Arg Gly Asn Gly Cys Pro Glu Glu Asp Asn Lys Glu Ala Ser Ala Leu
                805                 810                 815     
Gly Val Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu
            820                 825                 830         
Val Leu Ser Val Phe Val Ala Ile Gly Glu Phe Ile Tyr Lys Ser Arg
        835                 840                 845             
Lys Asn Asn Asp Ile Glu Gln Cys Leu Ser Phe Asn Ala Ile Met Glu
    850                 855                 860                 
Glu Leu Gly Ile Ser Leu Lys Asn Gln Lys Lys Ile Lys Lys Lys Ser
865                 870                 875                 880 
Arg Thr Lys Gly Lys Ser Ser Phe Thr Ser Ile Leu Thr Cys His Gln
                885                 890                 895     
Arg Arg Thr Gln Arg Lys Glu Thr Val Ala
            900                 905     


<210> 6408
<211> 353
<212> PRT
<213> Homo sapiens

<400> 6408
Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr
 1               5                  10                  15      
Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr
            20                  25                  30          
Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly
        35                  40                  45              
Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile
    50                  55                  60                  
Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr
65                  70                  75                  80  
Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys
                85                  90                  95      
Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser
            100                 105                 110         
Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro
        115                 120                 125             
His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser
    130                 135                 140                 
Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile
145                 150                 155                 160 
Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr
                165                 170                 175     
Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro
            180                 185                 190         
Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr
        195                 200                 205             
Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe
    210                 215                 220                 
His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys
225                 230                 235                 240 
Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe
                245                 250                 255     
Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser
            260                 265                 270         
Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln
        275                 280                 285             
Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro
    290                 295                 300                 
Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Met Glu Phe
305                 310                 315                 320 
His Ser Cys Cys Pro Gly Trp Ser Ala Met Ala Arg Ser His Leu Thr
                325                 330                 335     
Ala Thr Ser Ala Ser Trp Val Gln Ala Ile Leu Leu Pro Gln Pro Pro
            340                 345                 350         
Glu
    


<210> 6409
<211> 919
<212> PRT
<213> Homo sapiens

<400> 6409
Met Glu His Gly Thr Leu Leu Ala Gln Pro Gly Leu Trp Thr Arg Asp
 1               5                  10                  15      
Thr Ser Trp Ala Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr
            20                  25                  30          
Ala Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn
        35                  40                  45              
Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser
    50                  55                  60                  
Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp
65                  70                  75                  80  
Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala
                85                  90                  95      
Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His
            100                 105                 110         
Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val
        115                 120                 125             
Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Asn Lys Asp
    130                 135                 140                 
Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala
145                 150                 155                 160 
Ile Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val
                165                 170                 175     
Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala
            180                 185                 190         
Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Ser Gly
        195                 200                 205             
Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Gly Lys Glu
    210                 215                 220                 
Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu
225                 230                 235                 240 
Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe
                245                 250                 255     
Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr
            260                 265                 270         
Ser Gly Val Asn Met Thr Gly Phe Arg Leu Leu Asn Ile Asp Asn Pro
        275                 280                 285             
His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala
    290                 295                 300                 
Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu
305                 310                 315                 320 
Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His
                325                 330                 335     
Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys
            340                 345                 350         
Pro Trp Arg Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Ser
        355                 360                 365             
Arg Trp Asp Gly Leu Thr Gly His Ile Thr Phe Asn Lys Thr Asn Gly
    370                 375                 380                 
Leu Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly
385                 390                 395                 400 
Thr Glu Lys Ala Ala Gly Glu Val Ser Lys His Leu Tyr Lys Val Trp
                405                 410                 415     
Lys Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp
            420                 425                 430         
Ser Asn Lys Asp Lys Ser Ser Asn Ile Thr Asp Ser Leu Ala Asn Arg
        435                 440                 445             
Thr Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg
    450                 455                 460                 
Lys Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys
465                 470                 475                 480 
Leu Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Ile Tyr Asp
                485                 490                 495     
Val Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly
            500                 505                 510         
Glu Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu
        515                 520                 525             
Ala Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp
    530                 535                 540                 
Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys
545                 550                 555                 560 
Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser
                565                 570                 575     
Pro Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys
            580                 585                 590         
Val Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro
        595                 600                 605             
His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu
    610                 615                 620                 
Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser
625                 630                 635                 640 
Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp
                645                 650                 655     
Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala
            660                 665                 670         
Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp
        675                 680                 685             
Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly
    690                 695                 700                 
Ser Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys
705                 710                 715                 720 
Met Trp Ala Phe Met Ser Ser Arg Gln Gln Thr Ala Leu Val Arg Asn
                725                 730                 735     
Ser Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu
            740                 745                 750         
Met Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu
        755                 760                 765             
Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr
    770                 775                 780                 
Pro Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln
785                 790                 795                 800 
Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg
                805                 810                 815     
Gly Asn Gly Cys Pro Glu Glu Asp Asn Lys Glu Ala Ser Ala Leu Gly
            820                 825                 830         
Val Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val
        835                 840                 845             
Leu Ser Val Phe Val Ala Ile Gly Glu Phe Ile Tyr Lys Ser Arg Lys
    850                 855                 860                 
Asn Asn Asp Ile Glu Gln Ala Phe Cys Phe Phe Tyr Gly Leu Gln Cys
865                 870                 875                 880 
Lys Gln Thr His Pro Thr Asn Ser Thr Ser Gly Thr Thr Leu Ser Thr
                885                 890                 895     
Asp Leu Glu Cys Gly Lys Leu Ile Arg Glu Glu Arg Gly Ile Arg Lys
            900                 905                 910         
Gln Ser Ser Val His Thr Val
        915                 


<210> 6410
<211> 869
<212> PRT
<213> Homo sapiens

<400> 6410
Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr
 1               5                  10                  15      
Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr
            20                  25                  30          
Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly
        35                  40                  45              
Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile
    50                  55                  60                  
Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr
65                  70                  75                  80  
Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys
                85                  90                  95      
Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser
            100                 105                 110         
Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro
        115                 120                 125             
His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser
    130                 135                 140                 
Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile
145                 150                 155                 160 
Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr
                165                 170                 175     
Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro
            180                 185                 190         
Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr
        195                 200                 205             
Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe
    210                 215                 220                 
His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys
225                 230                 235                 240 
Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe
                245                 250                 255     
Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser
            260                 265                 270         
Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln
        275                 280                 285             
Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro
    290                 295                 300                 
Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala
305                 310                 315                 320 
Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln
                325                 330                 335     
Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro
            340                 345                 350         
Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp
        355                 360                 365             
Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg
    370                 375                 380                 
Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu
385                 390                 395                 400 
Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser
                405                 410                 415     
Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser
            420                 425                 430         
Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys
        435                 440                 445             
Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile
    450                 455                 460                 
Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile
465                 470                 475                 480 
Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly
                485                 490                 495     
Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu
            500                 505                 510         
Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp
        515                 520                 525             
Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys
    530                 535                 540                 
Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser
545                 550                 555                 560 
Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys
                565                 570                 575     
Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro
            580                 585                 590         
His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu
        595                 600                 605             
Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser
    610                 615                 620                 
Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp
625                 630                 635                 640 
Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala
                645                 650                 655     
Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp
            660                 665                 670         
Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly
        675                 680                 685             
Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys
    690                 695                 700                 
Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser
705                 710                 715                 720 
Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu
                725                 730                 735     
Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu
            740                 745                 750         
Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr
        755                 760                 765             
Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln
    770                 775                 780                 
Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg
785                 790                 795                 800 
Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly
                805                 810                 815     
Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val
            820                 825                 830         
Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys
        835                 840                 845             
Asn Ala Gln Leu Glu Lys Glu Ser Ser Ile Trp Leu Val Pro Pro Tyr
    850                 855                 860                 
His Pro Asp Thr Val
865                 


<210> 6411
<211> 908
<212> PRT
<213> Homo sapiens

<400> 6411
Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr
 1               5                  10                  15      
Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr
            20                  25                  30          
Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly
        35                  40                  45              
Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile
    50                  55                  60                  
Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr
65                  70                  75                  80  
Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys
                85                  90                  95      
Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser
            100                 105                 110         
Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro
        115                 120                 125             
His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser
    130                 135                 140                 
Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile
145                 150                 155                 160 
Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr
                165                 170                 175     
Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro
            180                 185                 190         
Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr
        195                 200                 205             
Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe
    210                 215                 220                 
His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys
225                 230                 235                 240 
Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe
                245                 250                 255     
Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser
            260                 265                 270         
Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln
        275                 280                 285             
Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro
    290                 295                 300                 
Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala
305                 310                 315                 320 
Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln
                325                 330                 335     
Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro
            340                 345                 350         
Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp
        355                 360                 365             
Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg
    370                 375                 380                 
Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu
385                 390                 395                 400 
Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser
                405                 410                 415     
Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser
            420                 425                 430         
Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys
        435                 440                 445             
Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile
    450                 455                 460                 
Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile
465                 470                 475                 480 
Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly
                485                 490                 495     
Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu
            500                 505                 510         
Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp
        515                 520                 525             
Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys
    530                 535                 540                 
Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser
545                 550                 555                 560 
Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys
                565                 570                 575     
Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro
            580                 585                 590         
His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu
        595                 600                 605             
Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser
    610                 615                 620                 
Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp
625                 630                 635                 640 
Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala
                645                 650                 655     
Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp
            660                 665                 670         
Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly
        675                 680                 685             
Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys
    690                 695                 700                 
Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser
705                 710                 715                 720 
Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu
                725                 730                 735     
Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu
            740                 745                 750         
Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr
        755                 760                 765             
Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln
    770                 775                 780                 
Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg
785                 790                 795                 800 
Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly
                805                 810                 815     
Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val
            820                 825                 830         
Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys
        835                 840                 845             
Asn Ala Gln Leu Glu Lys Arg Ser Phe Cys Ser Ala Met Val Glu Glu
    850                 855                 860                 
Leu Arg Met Ser Leu Lys Cys Gln Arg Arg Leu Lys His Lys Pro Gln
865                 870                 875                 880 
Ala Pro Val Ile Val Lys Thr Glu Glu Val Ile Asn Met His Thr Phe
                885                 890                 895     
Asn Asp Arg Arg Leu Pro Gly Lys Glu Thr Met Ala
            900                 905             


<210> 6412
<211> 302
<212> PRT
<213> Homo sapiens

<400> 6412
Met Arg Arg Asn Thr Gln Asp Glu Asn Met Arg Lys Trp Phe Lys Val
 1               5                  10                  15      
Thr Ile Cys Ile Phe Val Ser His Phe Thr Ala Pro Tyr Ser Val Lys
            20                  25                  30          
Asn Lys Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn
        35                  40                  45              
Lys Arg Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg
    50                  55                  60                  
Phe Asp Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg
65                  70                  75                  80  
Arg Asn Cys Met Ala Ala Thr Leu Lys Ile Thr Glu Arg Asn Phe Pro
                85                  90                  95      
Glu Leu Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp
            100                 105                 110         
Gly Leu Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn
        115                 120                 125             
Leu Ser Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys
    130                 135                 140                 
Gly Leu Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser
145                 150                 155                 160 
Thr Phe Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe
                165                 170                 175     
Pro Lys Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile
            180                 185                 190         
Val Asp Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe
        195                 200                 205             
Thr Gly Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln
    210                 215                 220                 
Ser Asn Leu Cys Lys Tyr Phe Lys Asp Ser Arg Asn Ile Lys Ile Leu
225                 230                 235                 240 
Lys Asp Pro Tyr Leu Gln Arg Lys Leu Leu Lys His Thr Lys Cys Pro
                245                 250                 255     
Arg Asn Val Asp Ser Leu Ser Ala Leu Pro Glu Thr Gln His Asp Phe
            260                 265                 270         
Thr Ser Ile Leu Val Asp Met Trp Tyr Gln Thr Val Asn Thr Cys Phe
        275                 280                 285             
Leu Pro Arg Ala Gly Pro Glu Ser Gln Arg Trp Val Gly Gly
    290                 295                 300         


<210> 6413
<211> 368
<212> PRT
<213> Homo sapiens

<400> 6413
Met Arg Arg Asn Thr Gln Asp Glu Asn Met Arg Lys Trp Phe Lys Val
 1               5                  10                  15      
Thr Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser
            20                  25                  30          
Ile Gln Ser Asn Cys Ser Val Pro Phe Thr Pro Val Asp Phe His Tyr
        35                  40                  45              
Ile Arg Asn Arg Ala Cys Phe Phe Val Gln Val Ala Ser Ala Ala Ser
    50                  55                  60                  
Ala Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys
65                  70                  75                  80  
Ile Cys Ile Phe Val Ser His Phe Thr Ala Pro Tyr Ser Val Lys Asn
                85                  90                  95      
Lys Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys
            100                 105                 110         
Arg Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe
        115                 120                 125             
Asp Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg
    130                 135                 140                 
Asn Cys Met Ala Ala Thr Leu Lys Ile Thr Glu Arg Asn Phe Pro Glu
145                 150                 155                 160 
Leu Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp Gly
                165                 170                 175     
Leu Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn Leu
            180                 185                 190         
Ser Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys Gly
        195                 200                 205             
Leu Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser Thr
    210                 215                 220                 
Phe Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe Pro
225                 230                 235                 240 
Lys Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile Val
                245                 250                 255     
Asp Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe Thr
            260                 265                 270         
Gly Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln Ser
        275                 280                 285             
Asn Leu Cys Lys Tyr Phe Lys Asp Ser Arg Asn Ile Lys Ile Leu Lys
    290                 295                 300                 
Asp Pro Tyr Leu Gln Arg Lys Leu Leu Lys His Thr Lys Cys Pro Arg
305                 310                 315                 320 
Asn Val Asp Ser Leu Ser Ala Leu Pro Glu Thr Gln His Asp Phe Thr
                325                 330                 335     
Ser Ile Leu Val Asp Met Trp Tyr Gln Thr Val Asn Thr Cys Phe Leu
            340                 345                 350         
Pro Arg Ala Gly Pro Glu Ser Gln Ser Gly Arg Met Val Ser Gly Phe
        355                 360                 365             


<210> 6414
<211> 397
<212> PRT
<213> Homo sapiens

<400> 6414
Met Arg Arg Asn Thr Gln Asp Glu Asn Met Arg Lys Trp Phe Lys Val
 1               5                  10                  15      
Thr Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser
            20                  25                  30          
Ile Gln Ser Asn Cys Ser Val Pro Phe Thr Pro Val Asp Phe His Tyr
        35                  40                  45              
Ile Arg Asn Arg Ala Cys Phe Phe Val Gln Val Ala Ser Ala Ala Ser
    50                  55                  60                  
Ala Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys
65                  70                  75                  80  
Ile Cys Ile Phe Val Ser His Phe Thr Ala Pro Tyr Ser Val Lys Asn
                85                  90                  95      
Lys Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys
            100                 105                 110         
Arg Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe
        115                 120                 125             
Asp Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg
    130                 135                 140                 
Asn Cys Met Ala Ala Thr Leu Lys Ile Thr Glu Arg Asn Phe Pro Glu
145                 150                 155                 160 
Leu Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp Gly
                165                 170                 175     
Leu Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn Leu
            180                 185                 190         
Ser Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys Gly
        195                 200                 205             
Leu Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser Thr
    210                 215                 220                 
Phe Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe Pro
225                 230                 235                 240 
Lys Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile Val
                245                 250                 255     
Asp Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe Thr
            260                 265                 270         
Gly Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln Ser
        275                 280                 285             
Asn Leu Cys Lys Tyr Phe Lys Asp Ser Arg Asn Ile Lys Ile Leu Lys
    290                 295                 300                 
Asp Pro Tyr Leu Gln Arg Lys Leu Leu Lys His Thr Lys Cys Pro Arg
305                 310                 315                 320 
Asn Val Asp Ser Leu Ser Ala Leu Pro Glu Thr Gln His Asp Phe Thr
                325                 330                 335     
Ser Ile Leu Val Asp Met Trp Tyr Gln Thr Val Asn Thr Cys Phe Leu
            340                 345                 350         
Pro Arg Ala Gly Pro Glu Ser Gln Arg Trp Trp Cys Leu Leu Ser Leu
        355                 360                 365             
Lys Trp Lys Asp Gly Leu Arg Val Leu Ile Leu Pro Ser Cys Gly Pro
    370                 375                 380                 
Ser Ser Leu Pro Leu Ala Ala Ile Pro Val Cys Ala Ser
385                 390                 395         


<210> 6415
<211> 626
<212> PRT
<213> Homo sapiens

<400> 6415
Met Cys Ser Thr Leu Lys Lys Cys Gly Thr Tyr Arg Thr Glu Val Ala
 1               5                  10                  15      
Glu Cys His Asp His Gly Ser Thr Phe Gln Gly Arg Lys Lys Gly Gly
            20                  25                  30          
Ser Ser Phe Arg Asp Asn Phe Asp Lys Arg Ser Cys His Tyr Glu His
        35                  40                  45              
Gly Gly Tyr Glu Arg Pro Pro Ser His Cys Gln Glu Asn Asp Gly Ser
    50                  55                  60                  
Val Glu Met Arg Asp Val His Lys Asp Gln Gln Leu Arg His Thr Pro
65                  70                  75                  80  
Tyr Ser Ile Arg Cys Glu Arg Arg Met Lys Trp His Ser Glu Asp Glu
                85                  90                  95      
Ile Arg Ile Thr Thr Trp Arg Asn Arg Lys Pro Pro Glu Arg Lys Met
            100                 105                 110         
Ser Gln Asn Thr Gln Asp Gly Tyr Thr Arg Asn Trp Phe Lys Val Thr
        115                 120                 125             
Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser Ile
    130                 135                 140                 
Gln Ser His Cys Ser Asp Arg Phe Thr Pro Val Asp Phe His Tyr Val
145                 150                 155                 160 
Arg Asn Arg Ala Cys Phe Phe Val Gln Asp Ala Ser Ala Ala Ser Ala
                165                 170                 175     
Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys Ile
            180                 185                 190         
Cys Ile Phe Val Asn His Ser Thr Ala Pro Tyr Ser Val Lys Asn Lys
        195                 200                 205             
Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys Arg
    210                 215                 220                 
Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe Asp
225                 230                 235                 240 
Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg Asn
                245                 250                 255     
Cys Met Ala Ala Thr Leu Lys Ile Ile Glu Arg Asn Phe Pro Glu Leu
            260                 265                 270         
Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp Gly Leu
        275                 280                 285             
Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn Leu Ser
    290                 295                 300                 
Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys Gly Leu
305                 310                 315                 320 
Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser Thr Phe
                325                 330                 335     
Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe Pro Lys
            340                 345                 350         
Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile Val Asp
        355                 360                 365             
Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe Thr Gly
    370                 375                 380                 
Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln Tyr Tyr
385                 390                 395                 400 
Ser Ile Tyr Asp Ser Gly Asp Arg Gln Gly Leu Leu Gly Ala Tyr His
                405                 410                 415     
Asp Glu Ala Cys Phe Ser Leu Ala Ile Pro Phe Asp Pro Lys Asp Ser
            420                 425                 430         
Ala Pro Ser Ser Leu Cys Lys Tyr Phe Glu Asp Ser Arg Asn Met Lys
        435                 440                 445             
Thr Leu Lys Asp Pro Tyr Leu Lys Gly Glu Leu Leu Arg Arg Thr Lys
    450                 455                 460                 
Arg Asp Ile Val Asp Ser Leu Ser Ala Leu Pro Lys Thr Gln His Asp
465                 470                 475                 480 
Leu Ser Ser Ile Leu Val Asp Val Trp Cys Gln Thr Glu Arg Met Leu
                485                 490                 495     
Cys Phe Ser Val Asn Gly Val Phe Lys Glu Val Glu Gly Gln Ser Gln
            500                 505                 510         
Gly Ser Val Leu Ala Phe Thr Arg Thr Phe Ile Ala Thr Pro Gly Ser
        515                 520                 525             
Ser Ser Ser Leu Cys Ile Val Asn Asp Glu Leu Phe Val Arg Asp Ala
    530                 535                 540                 
Ser Pro Gln Glu Thr Gln Ser Ala Phe Ser Ile Pro Val Ser Thr Leu
545                 550                 555                 560 
Ser Ser Ser Ser Glu Pro Ser Leu Ser Gln Glu Gln Gln Glu Met Val
                565                 570                 575     
Gln Ala Phe Ser Ala Gln Ser Gly Met Lys Leu Glu Trp Ser Gln Lys
            580                 585                 590         
Cys Leu Gln Asp Asn Glu Trp Asn Tyr Thr Arg Ala Gly Gln Ala Phe
        595                 600                 605             
Thr Met Leu Gln Thr Glu Gly Lys Ile Pro Ala Glu Ala Phe Lys Gln
    610                 615                 620                 
Ile Ser
625     


<210> 6416
<211> 305
<212> PRT
<213> Homo sapiens

<400> 6416
Met Arg Arg Asn Thr Gln Asp Glu Asn Met Arg Lys Trp Phe Lys Val
 1               5                  10                  15      
Thr Ile Cys Ile Phe Val Ser His Phe Thr Ala Pro Tyr Ser Val Lys
            20                  25                  30          
Asn Lys Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn
        35                  40                  45              
Lys Arg Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg
    50                  55                  60                  
Phe Asp Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg
65                  70                  75                  80  
Arg Asn Cys Met Ala Ala Thr Leu Lys Ile Thr Glu Arg Asn Phe Pro
                85                  90                  95      
Glu Leu Leu Ser Leu Asn Leu Cys Asn Asn Lys Leu Tyr Gln Leu Asp
            100                 105                 110         
Gly Leu Ser Asp Ile Thr Glu Lys Ala Pro Lys Val Lys Thr Leu Asn
        115                 120                 125             
Leu Ser Lys Asn Lys Leu Glu Ser Ala Trp Glu Leu Gly Lys Val Lys
    130                 135                 140                 
Gly Leu Lys Leu Glu Glu Leu Trp Leu Glu Gly Asn Pro Leu Cys Ser
145                 150                 155                 160 
Thr Phe Ser Asp Gln Ser Ala Tyr Val Ser Ala Ile Arg Asp Cys Phe
                165                 170                 175     
Pro Lys Leu Leu Arg Leu Asp Gly Arg Glu Leu Ser Ala Pro Val Ile
            180                 185                 190         
Val Asp Ile Asp Ser Ser Glu Thr Met Lys Pro Cys Lys Glu Asn Phe
        195                 200                 205             
Thr Gly Ser Glu Thr Leu Lys His Leu Val Leu Gln Phe Leu Gln Gln
    210                 215                 220                 
Ser Asn Leu Cys Lys Tyr Phe Lys Asp Ser Arg Asn Ile Lys Ile Leu
225                 230                 235                 240 
Lys Asp Pro Tyr Leu Gln Arg Lys Leu Leu Lys His Thr Lys Cys Pro
                245                 250                 255     
Arg Asn Val Asp Ser Leu Ser Ala Leu Pro Glu Thr Gln His Asp Phe
            260                 265                 270         
Thr Ser Ile Leu Val Asp Met Trp Tyr Gln Thr Val Asn Thr Cys Phe
        275                 280                 285             
Leu Pro Arg Ala Gly Pro Glu Ser Gln Ser Gly Arg Met Val Ser Gly
    290                 295                 300                 
Phe
305 


<210> 6417
<211> 168
<212> PRT
<213> Homo sapiens

<400> 6417
Met Arg Arg Asn Thr Gln Asp Glu Asn Met Arg Lys Trp Phe Lys Val
 1               5                  10                  15      
Thr Ile Pro Tyr Gly Ile Lys Tyr Asp Lys Ala Trp Leu Met Asn Ser
            20                  25                  30          
Ile Gln Ser Asn Cys Ser Val Pro Phe Thr Pro Val Asp Phe His Tyr
        35                  40                  45              
Ile Arg Asn Arg Ala Cys Phe Phe Val Gln Val Ala Ser Ala Ala Ser
    50                  55                  60                  
Ala Leu Lys Asp Val Ser Tyr Lys Ile Tyr Asp Asp Glu Asn Gln Lys
65                  70                  75                  80  
Ile Cys Ile Phe Val Ser His Phe Thr Ala Pro Tyr Ser Val Lys Asn
                85                  90                  95      
Lys Leu Lys Pro Gly Gln Met Glu Met Leu Lys Leu Thr Met Asn Lys
            100                 105                 110         
Arg Tyr Asn Val Ser Gln Gln Ala Leu Asp Leu Gln Asn Leu Arg Phe
        115                 120                 125             
Asp Pro Asp Leu Met Gly Arg Asp Ile Asp Ile Ile Leu Asn Arg Arg
    130                 135                 140                 
Asn Cys Met Ala Ala Thr Leu Lys Ile Thr Glu Arg Asn Phe Pro Glu
145                 150                 155                 160 
Arg Arg Leu Pro Lys Ser Arg Pro
                165             


<210> 6418
<211> 793
<212> PRT
<213> Homo sapiens

<400> 6418
Met Asp Ser Trp Phe Ile Leu Val Leu Leu Gly Ser Gly Leu Ile Cys
 1               5                  10                  15      
Val Ser Ala Asn Asn Ala Thr Thr Val Ala Pro Ser Val Gly Ile Thr
            20                  25                  30          
Arg Leu Ile Asn Ser Ser Thr Ala Glu Pro Val Lys Glu Glu Ala Lys
        35                  40                  45              
Thr Ser Asn Pro Thr Ser Ser Leu Thr Ser Leu Ser Val Ala Pro Thr
    50                  55                  60                  
Phe Ser Pro Asn Ile Thr Leu Gly Pro Thr Tyr Leu Thr Thr Val Asn
65                  70                  75                  80  
Ser Ser Asp Ser Asp Asn Gly Thr Thr Arg Thr Ala Ser Thr Asn Ser
                85                  90                  95      
Ile Gly Ile Thr Ile Ser Pro Asn Gly Thr Trp Leu Pro Asp Asn Gln
            100                 105                 110         
Phe Thr Asp Ala Arg Thr Glu Pro Trp Glu Gly Asn Ser Ser Thr Ala
        115                 120                 125             
Ala Thr Thr Pro Glu Thr Phe Pro Pro Ser Asp Glu Thr Pro Ile Ile
    130                 135                 140                 
Ala Val Met Val Ala Leu Ser Ser Leu Leu Val Ile Val Phe Ile Ile
145                 150                 155                 160 
Ile Val Leu Tyr Met Leu Arg Phe Lys Lys Tyr Lys Gln Ala Gly Ser
                165                 170                 175     
His Ser Asn Ser Phe Arg Leu Ser Asn Gly Arg Thr Glu Asp Val Glu
            180                 185                 190         
Pro Gln Ser Val Pro Leu Leu Ala Arg Ser Pro Ser Thr Asn Arg Lys
        195                 200                 205             
Tyr Pro Pro Leu Pro Val Asp Lys Leu Glu Glu Glu Ile Asn Arg Arg
    210                 215                 220                 
Met Ala Asp Asp Asn Lys Leu Phe Arg Glu Glu Phe Asn Ala Leu Pro
225                 230                 235                 240 
Ala Cys Pro Ile Gln Ala Thr Cys Glu Ala Ala Ser Lys Glu Glu Asn
                245                 250                 255     
Lys Glu Lys Asn Arg Tyr Val Asn Ile Leu Pro Tyr Asp His Ser Arg
            260                 265                 270         
Val His Leu Thr Pro Val Glu Gly Val Pro Asp Ser Asp Tyr Ile Asn
        275                 280                 285             
Ala Ser Phe Ile Asn Gly Tyr Gln Glu Lys Asn Lys Phe Ile Ala Ala
    290                 295                 300                 
Gln Gly Pro Lys Glu Glu Thr Val Asn Asp Phe Trp Arg Met Ile Trp
305                 310                 315                 320 
Glu Gln Asn Thr Ala Thr Ile Val Met Val Thr Asn Leu Lys Glu Arg
                325                 330                 335     
Lys Glu Cys Lys Cys Ala Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr
            340                 345                 350         
Tyr Gly Asn Ile Arg Val Ser Val Glu Asp Val Thr Val Leu Val Asp
        355                 360                 365             
Tyr Thr Val Arg Lys Phe Cys Ile Gln Gln Val Gly Asp Met Thr Asn
    370                 375                 380                 
Arg Lys Pro Gln Arg Leu Ile Thr Gln Phe His Phe Thr Ser Trp Pro
385                 390                 395                 400 
Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys
                405                 410                 415     
Lys Val Lys Ala Cys Asn Pro Gln Tyr Ala Gly Ala Ile Val Val His
            420                 425                 430         
Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Val Val Ile Asp Ala
        435                 440                 445             
Met Leu Asp Met Met His Thr Glu Arg Lys Val Asp Val Tyr Gly Phe
    450                 455                 460                 
Val Ser Arg Ile Arg Ala Gln Arg Cys Gln Met Val Gln Thr Asp Met
465                 470                 475                 480 
Gln Tyr Val Phe Ile Tyr Gln Ala Leu Leu Glu His Tyr Leu Tyr Gly
                485                 490                 495     
Asp Thr Glu Leu Glu Val Thr Ser Leu Glu Thr His Leu Gln Lys Ile
            500                 505                 510         
Tyr Asn Lys Ile Pro Gly Thr Ser Asn Asn Gly Leu Glu Glu Glu Phe
        515                 520                 525             
Lys Lys Leu Thr Ser Ile Lys Ile Gln Asn Asp Lys Met Arg Thr Gly
    530                 535                 540                 
Asn Leu Pro Ala Asn Met Lys Lys Asn Arg Val Leu Gln Ile Ile Pro
545                 550                 555                 560 
Tyr Glu Phe Asn Arg Val Ile Ile Pro Val Lys Arg Gly Glu Glu Asn
                565                 570                 575     
Thr Asp Tyr Val Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp
            580                 585                 590         
Ser Tyr Ile Ala Ser Gln Gly Pro Leu Leu His Thr Ile Glu Asp Phe
        595                 600                 605             
Trp Arg Met Ile Trp Glu Trp Lys Ser Cys Ser Ile Val Met Leu Thr
    610                 615                 620                 
Glu Leu Glu Glu Arg Gly Gln Glu Lys Cys Ala Gln Tyr Trp Pro Ser
625                 630                 635                 640 
Asp Gly Leu Val Ser Tyr Gly Asp Ile Thr Val Glu Leu Lys Lys Glu
                645                 650                 655     
Glu Glu Cys Glu Ser Tyr Thr Val Arg Asp Leu Leu Val Thr Asn Thr
            660                 665                 670         
Arg Glu Asn Lys Ser Arg Gln Ile Arg Gln Phe His Phe His Gly Trp
        675                 680                 685             
Pro Glu Val Gly Ile Pro Ser Asp Gly Lys Gly Met Ile Ser Ile Ile
    690                 695                 700                 
Ala Ala Val Gln Lys Gln Gln Gln Gln Ser Gly Asn His Pro Ile Thr
705                 710                 715                 720 
Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe Cys Ala Leu
                725                 730                 735     
Ser Thr Val Leu Glu Arg Val Lys Ala Glu Gly Ile Leu Asp Val Phe
            740                 745                 750         
Gln Thr Val Lys Ser Leu Arg Leu Gln Arg Pro His Met Val Gln Thr
        755                 760                 765             
Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Glu Tyr Ile Asp
    770                 775                 780                 
Ala Phe Ser Asp Tyr Ala Asn Phe Lys
785                 790             


<210> 6419
<211> 802
<212> PRT
<213> Homo sapiens

<400> 6419
Met Asp Ser Trp Phe Ile Leu Val Leu Leu Gly Ser Gly Leu Ile Cys
 1               5                  10                  15      
Val Ser Ala Asn Asn Ala Thr Thr Val Ala Pro Ser Val Gly Ile Thr
            20                  25                  30          
Arg Leu Ile Asn Ser Ser Thr Ala Glu Pro Val Lys Glu Glu Ala Lys
        35                  40                  45              
Thr Ser Asn Pro Thr Ser Ser Leu Thr Ser Leu Ser Val Ala Pro Thr
    50                  55                  60                  
Phe Ser Pro Asn Ile Thr Leu Gly Pro Thr Tyr Leu Thr Thr Val Asn
65                  70                  75                  80  
Ser Ser Asp Ser Asp Asn Gly Thr Thr Arg Thr Ala Ser Thr Asn Ser
                85                  90                  95      
Ile Gly Ile Thr Ile Ser Pro Asn Gly Thr Trp Leu Pro Asp Asn Gln
            100                 105                 110         
Phe Thr Asp Ala Arg Thr Glu Pro Trp Glu Gly Asn Ser Ser Thr Ala
        115                 120                 125             
Ala Thr Thr Pro Glu Thr Phe Pro Pro Ser Asp Glu Thr Pro Ile Ile
    130                 135                 140                 
Ala Val Met Val Ala Leu Ser Ser Leu Leu Val Ile Val Phe Ile Ile
145                 150                 155                 160 
Ile Val Leu Tyr Met Leu Arg Phe Lys Lys Tyr Lys Gln Ala Gly Ser
                165                 170                 175     
His Ser Asn Ser Lys Gln Ala Gly Ser His Ser Asn Ser Phe Arg Leu
            180                 185                 190         
Ser Asn Gly Arg Thr Glu Asp Val Glu Pro Gln Ser Val Pro Leu Leu
        195                 200                 205             
Ala Arg Ser Pro Ser Thr Asn Arg Lys Tyr Pro Pro Leu Pro Val Asp
    210                 215                 220                 
Lys Leu Glu Glu Glu Ile Asn Arg Arg Met Ala Asp Asp Asn Lys Leu
225                 230                 235                 240 
Phe Arg Glu Glu Phe Asn Ala Leu Pro Ala Cys Pro Ile Gln Ala Thr
                245                 250                 255     
Cys Glu Ala Ala Ser Lys Glu Glu Asn Lys Glu Lys Asn Arg Tyr Val
            260                 265                 270         
Asn Ile Leu Pro Tyr Asp His Ser Arg Val His Leu Thr Pro Val Glu
        275                 280                 285             
Gly Val Pro Asp Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asn Gly Tyr
    290                 295                 300                 
Gln Glu Lys Asn Lys Phe Ile Ala Ala Gln Gly Pro Lys Glu Glu Thr
305                 310                 315                 320 
Val Asn Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr Ala Thr Ile
                325                 330                 335     
Val Met Val Thr Asn Leu Lys Glu Arg Lys Glu Cys Lys Cys Ala Gln
            340                 345                 350         
Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr Gly Asn Ile Arg Val Ser
        355                 360                 365             
Val Glu Asp Val Thr Val Leu Val Asp Tyr Thr Val Arg Lys Phe Cys
    370                 375                 380                 
Ile Gln Gln Val Gly Asp Met Thr Asn Arg Lys Pro Gln Arg Leu Ile
385                 390                 395                 400 
Thr Gln Phe His Phe Thr Ser Trp Pro Asp Phe Gly Val Pro Phe Thr
                405                 410                 415     
Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val Lys Ala Cys Asn Pro
            420                 425                 430         
Gln Tyr Ala Gly Ala Ile Val Val His Cys Ser Ala Gly Val Gly Arg
        435                 440                 445             
Thr Gly Thr Phe Val Val Ile Asp Ala Met Leu Asp Met Met His Thr
    450                 455                 460                 
Glu Arg Lys Val Asp Val Tyr Gly Phe Val Ser Arg Ile Arg Ala Gln
465                 470                 475                 480 
Arg Cys Gln Met Val Gln Thr Asp Met Gln Tyr Val Phe Ile Tyr Gln
                485                 490                 495     
Ala Leu Leu Glu His Tyr Leu Tyr Gly Asp Thr Glu Leu Glu Val Thr
            500                 505                 510         
Ser Leu Glu Thr His Leu Gln Lys Ile Tyr Asn Lys Ile Pro Gly Thr
        515                 520                 525             
Ser Asn Asn Gly Leu Glu Glu Glu Phe Lys Lys Leu Thr Ser Ile Lys
    530                 535                 540                 
Ile Gln Asn Asp Lys Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys
545                 550                 555                 560 
Lys Asn Arg Val Leu Gln Ile Ile Pro Tyr Glu Phe Asn Arg Val Ile
                565                 570                 575     
Ile Pro Val Lys Arg Gly Glu Glu Asn Thr Asp Tyr Val Asn Ala Ser
            580                 585                 590         
Phe Ile Asp Gly Tyr Arg Gln Lys Asp Ser Tyr Ile Ala Ser Gln Gly
        595                 600                 605             
Pro Leu Leu His Thr Ile Glu Asp Phe Trp Arg Met Ile Trp Glu Trp
    610                 615                 620                 
Lys Ser Cys Ser Ile Val Met Leu Thr Glu Leu Glu Glu Arg Gly Gln
625                 630                 635                 640 
Glu Lys Cys Ala Gln Tyr Trp Pro Ser Asp Gly Leu Val Ser Tyr Gly
                645                 650                 655     
Asp Ile Thr Val Glu Leu Lys Lys Glu Glu Glu Cys Glu Ser Tyr Thr
            660                 665                 670         
Val Arg Asp Leu Leu Val Thr Asn Thr Arg Glu Asn Lys Ser Arg Gln
        675                 680                 685             
Ile Arg Gln Phe His Phe His Gly Trp Pro Glu Val Gly Ile Pro Ser
    690                 695                 700                 
Asp Gly Lys Gly Met Ile Ser Ile Ile Ala Ala Val Gln Lys Gln Gln
705                 710                 715                 720 
Gln Gln Ser Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly Ala
                725                 730                 735     
Gly Arg Thr Gly Thr Phe Cys Ala Leu Ser Thr Val Leu Glu Arg Val
            740                 745                 750         
Lys Ala Glu Gly Ile Leu Asp Val Phe Gln Thr Val Lys Ser Leu Arg
        755                 760                 765             
Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys
    770                 775                 780                 
Tyr Lys Val Val Gln Glu Tyr Ile Asp Ala Phe Ser Asp Tyr Ala Asn
785                 790                 795                 800 
Phe Lys
        


<210> 6420
<211> 802
<212> PRT
<213> Homo sapiens

<400> 6420
Met Asp Ser Trp Phe Ile Leu Val Leu Leu Gly Ser Gly Leu Ile Cys
 1               5                  10                  15      
Val Ser Ala Asn Asn Ala Thr Thr Val Ala Pro Ser Val Gly Ile Thr
            20                  25                  30          
Arg Leu Ile Asn Ser Ser Thr Ala Glu Pro Val Lys Glu Glu Ala Lys
        35                  40                  45              
Thr Ser Asn Pro Thr Ser Ser Leu Thr Ser Leu Ser Val Ala Pro Thr
    50                  55                  60                  
Phe Ser Pro Asn Ile Thr Leu Gly Pro Thr Tyr Leu Thr Thr Val Asn
65                  70                  75                  80  
Ser Ser Asp Ser Asp Asn Gly Thr Thr Arg Thr Ala Ser Thr Asn Ser
                85                  90                  95      
Ile Gly Ile Thr Ile Ser Pro Asn Gly Thr Trp Leu Pro Asp Asn Gln
            100                 105                 110         
Phe Thr Asp Ala Arg Thr Glu Pro Trp Glu Gly Asn Ser Ser Thr Ala
        115                 120                 125             
Ala Thr Thr Pro Glu Thr Phe Pro Pro Ser Gly Asn Ser Asp Ser Lys
    130                 135                 140                 
Asp Arg Arg Asp Glu Thr Pro Ile Ile Ala Val Met Val Ala Leu Ser
145                 150                 155                 160 
Ser Leu Leu Val Ile Val Phe Ile Ile Ile Val Leu Tyr Met Leu Arg
                165                 170                 175     
Phe Lys Lys Tyr Lys Gln Ala Gly Ser His Ser Asn Ser Phe Arg Leu
            180                 185                 190         
Ser Asn Gly Arg Thr Glu Asp Val Glu Pro Gln Ser Val Pro Leu Leu
        195                 200                 205             
Ala Arg Ser Pro Ser Thr Asn Arg Lys Tyr Pro Pro Leu Pro Val Asp
    210                 215                 220                 
Lys Leu Glu Glu Glu Ile Asn Arg Arg Met Ala Asp Asp Asn Lys Leu
225                 230                 235                 240 
Phe Arg Glu Glu Phe Asn Ala Leu Pro Ala Cys Pro Ile Gln Ala Thr
                245                 250                 255     
Cys Glu Ala Ala Ser Lys Glu Glu Asn Lys Glu Lys Asn Arg Tyr Val
            260                 265                 270         
Asn Ile Leu Pro Tyr Asp His Ser Arg Val His Leu Thr Pro Val Glu
        275                 280                 285             
Gly Val Pro Asp Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asn Gly Tyr
    290                 295                 300                 
Gln Glu Lys Asn Lys Phe Ile Ala Ala Gln Gly Pro Lys Glu Glu Thr
305                 310                 315                 320 
Val Asn Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr Ala Thr Ile
                325                 330                 335     
Val Met Val Thr Asn Leu Lys Glu Arg Lys Glu Cys Lys Cys Ala Gln
            340                 345                 350         
Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr Gly Asn Ile Arg Val Ser
        355                 360                 365             
Val Glu Asp Val Thr Val Leu Val Asp Tyr Thr Val Arg Lys Phe Cys
    370                 375                 380                 
Ile Gln Gln Val Gly Asp Met Thr Asn Arg Lys Pro Gln Arg Leu Ile
385                 390                 395                 400 
Thr Gln Phe His Phe Thr Ser Trp Pro Asp Phe Gly Val Pro Phe Thr
                405                 410                 415     
Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val Lys Ala Cys Asn Pro
            420                 425                 430         
Gln Tyr Ala Gly Ala Ile Val Val His Cys Ser Ala Gly Val Gly Arg
        435                 440                 445             
Thr Gly Thr Phe Val Val Ile Asp Ala Met Leu Asp Met Met His Thr
    450                 455                 460                 
Glu Arg Lys Val Asp Val Tyr Gly Phe Val Ser Arg Ile Arg Ala Gln
465                 470                 475                 480 
Arg Cys Gln Met Val Gln Thr Asp Met Gln Tyr Val Phe Ile Tyr Gln
                485                 490                 495     
Ala Leu Leu Glu His Tyr Leu Tyr Gly Asp Thr Glu Leu Glu Val Thr
            500                 505                 510         
Ser Leu Glu Thr His Leu Gln Lys Ile Tyr Asn Lys Ile Pro Gly Thr
        515                 520                 525             
Ser Asn Asn Gly Leu Glu Glu Glu Phe Lys Lys Leu Thr Ser Ile Lys
    530                 535                 540                 
Ile Gln Asn Asp Lys Met Arg Thr Gly Asn Leu Pro Ala Asn Met Lys
545                 550                 555                 560 
Lys Asn Arg Val Leu Gln Ile Ile Pro Tyr Glu Phe Asn Arg Val Ile
                565                 570                 575     
Ile Pro Val Lys Arg Gly Glu Glu Asn Thr Asp Tyr Val Asn Ala Ser
            580                 585                 590         
Phe Ile Asp Gly Tyr Arg Gln Lys Asp Ser Tyr Ile Ala Ser Gln Gly
        595                 600                 605             
Pro Leu Leu His Thr Ile Glu Asp Phe Trp Arg Met Ile Trp Glu Trp
    610                 615                 620                 
Lys Ser Cys Ser Ile Val Met Leu Thr Glu Leu Glu Glu Arg Gly Gln
625                 630                 635                 640 
Glu Lys Cys Ala Gln Tyr Trp Pro Ser Asp Gly Leu Val Ser Tyr Gly
                645                 650                 655     
Asp Ile Thr Val Glu Leu Lys Lys Glu Glu Glu Cys Glu Ser Tyr Thr
            660                 665                 670         
Val Arg Asp Leu Leu Val Thr Asn Thr Arg Glu Asn Lys Ser Arg Gln
        675                 680                 685             
Ile Arg Gln Phe His Phe His Gly Trp Pro Glu Val Gly Ile Pro Ser
    690                 695                 700                 
Asp Gly Lys Gly Met Ile Ser Ile Ile Ala Ala Val Gln Lys Gln Gln
705                 710                 715                 720 
Gln Gln Ser Gly Asn His Pro Ile Thr Val His Cys Ser Ala Gly Ala
                725                 730                 735     
Gly Arg Thr Gly Thr Phe Cys Ala Leu Ser Thr Val Leu Glu Arg Val
            740                 745                 750         
Lys Ala Glu Gly Ile Leu Asp Val Phe Gln Thr Val Lys Ser Leu Arg
        755                 760                 765             
Leu Gln Arg Pro His Met Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys
    770                 775                 780                 
Tyr Lys Val Val Gln Glu Tyr Ile Asp Ala Phe Ser Asp Tyr Ala Asn
785                 790                 795                 800 
Phe Lys
        


<210> 6421
<211> 793
<212> PRT
<213> Homo sapiens

<400> 6421
Met Asp Ser Trp Phe Ile Leu Val Leu Leu Gly Ser Gly Leu Ile Cys
 1               5                  10                  15      
Val Ser Ala Asn Asn Ala Thr Thr Val Ala Pro Ser Val Gly Ile Thr
            20                  25                  30          
Arg Leu Ile Asn Ser Ser Thr Ala Glu Pro Val Lys Glu Glu Ala Lys
        35                  40                  45              
Thr Ser Asn Pro Thr Ser Ser Leu Thr Ser Leu Ser Val Ala Pro Thr
    50                  55                  60                  
Phe Ser Pro Asn Ile Thr Leu Gly Pro Thr Tyr Leu Thr Thr Val Asn
65                  70                  75                  80  
Ser Ser Asp Ser Asp Asn Gly Thr Thr Arg Thr Ala Ser Thr Asn Ser
                85                  90                  95      
Ile Gly Ile Thr Ile Ser Pro Asn Gly Thr Trp Leu Pro Asp Asn Gln
            100                 105                 110         
Phe Thr Asp Ala Arg Thr Glu Pro Trp Glu Gly Asn Ser Ser Thr Ala
        115                 120                 125             
Ala Thr Thr Pro Glu Thr Phe Pro Pro Ser Val Ala Leu Ser Ser Leu
    130                 135                 140                 
Leu Val Ile Val Phe Ile Ile Ile Val Leu Tyr Met Leu Arg Phe Lys
145                 150                 155                 160 
Lys Tyr Lys Gln Ala Gly Ser His Ser Asn Ser Lys Gln Ala Gly Ser
                165                 170                 175     
His Ser Asn Ser Phe Arg Leu Ser Asn Gly Arg Thr Glu Asp Val Glu
            180                 185                 190         
Pro Gln Ser Val Pro Leu Leu Ala Arg Ser Pro Ser Thr Asn Arg Lys
        195                 200                 205             
Tyr Pro Pro Leu Pro Val Asp Lys Leu Glu Glu Glu Ile Asn Arg Arg
    210                 215                 220                 
Met Ala Asp Asp Asn Lys Leu Phe Arg Glu Glu Phe Asn Ala Leu Pro
225                 230                 235                 240 
Ala Cys Pro Ile Gln Ala Thr Cys Glu Ala Ala Ser Lys Glu Glu Asn
                245                 250                 255     
Lys Glu Lys Asn Arg Tyr Val Asn Ile Leu Pro Tyr Asp His Ser Arg
            260                 265                 270         
Val His Leu Thr Pro Val Glu Gly Val Pro Asp Ser Asp Tyr Ile Asn
        275                 280                 285             
Ala Ser Phe Ile Asn Gly Tyr Gln Glu Lys Asn Lys Phe Ile Ala Ala
    290                 295                 300                 
Gln Gly Pro Lys Glu Glu Thr Val Asn Asp Phe Trp Arg Met Ile Trp
305                 310                 315                 320 
Glu Gln Asn Thr Ala Thr Ile Val Met Val Thr Asn Leu Lys Glu Arg
                325                 330                 335     
Lys Glu Cys Lys Cys Ala Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr
            340                 345                 350         
Tyr Gly Asn Ile Arg Val Ser Val Glu Asp Val Thr Val Leu Val Asp
        355                 360                 365             
Tyr Thr Val Arg Lys Phe Cys Ile Gln Gln Val Gly Asp Met Thr Asn
    370                 375                 380                 
Arg Lys Pro Gln Arg Leu Ile Thr Gln Phe His Phe Thr Ser Trp Pro
385                 390                 395                 400 
Asp Phe Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys
                405                 410                 415     
Lys Val Lys Ala Cys Asn Pro Gln Tyr Ala Gly Ala Ile Val Val His
            420                 425                 430         
Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Val Val Ile Asp Ala
        435                 440                 445             
Met Leu Asp Met Met His Thr Glu Arg Lys Val Asp Val Tyr Gly Phe
    450                 455                 460                 
Val Ser Arg Ile Arg Ala Gln Arg Cys Gln Met Val Gln Thr Asp Met
465                 470                 475                 480 
Gln Tyr Val Phe Ile Tyr Gln Ala Leu Leu Glu His Tyr Leu Tyr Gly
                485                 490                 495     
Asp Thr Glu Leu Glu Val Thr Ser Leu Glu Thr His Leu Gln Lys Ile
            500                 505                 510         
Tyr Asn Lys Ile Pro Gly Thr Ser Asn Asn Gly Leu Glu Glu Glu Phe
        515                 520                 525             
Lys Lys Leu Thr Ser Ile Lys Ile Gln Asn Asp Lys Met Arg Thr Gly
    530                 535                 540                 
Asn Leu Pro Ala Asn Met Lys Lys Asn Arg Val Leu Gln Ile Ile Pro
545                 550                 555                 560 
Tyr Glu Phe Asn Arg Val Ile Ile Pro Val Lys Arg Gly Glu Glu Asn
                565                 570                 575     
Thr Asp Tyr Val Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp
            580                 585                 590         
Ser Tyr Ile Ala Ser Gln Gly Pro Leu Leu His Thr Ile Glu Asp Phe
        595                 600                 605             
Trp Arg Met Ile Trp Glu Trp Lys Ser Cys Ser Ile Val Met Leu Thr
    610                 615                 620                 
Glu Leu Glu Glu Arg Gly Gln Glu Lys Cys Ala Gln Tyr Trp Pro Ser
625                 630                 635                 640 
Asp Gly Leu Val Ser Tyr Gly Asp Ile Thr Val Glu Leu Lys Lys Glu
                645                 650                 655     
Glu Glu Cys Glu Ser Tyr Thr Val Arg Asp Leu Leu Val Thr Asn Thr
            660                 665                 670         
Arg Glu Asn Lys Ser Arg Gln Ile Arg Gln Phe His Phe His Gly Trp
        675                 680                 685             
Pro Glu Val Gly Ile Pro Ser Asp Gly Lys Gly Met Ile Ser Ile Ile
    690                 695                 700                 
Ala Ala Val Gln Lys Gln Gln Gln Gln Ser Gly Asn His Pro Ile Thr
705                 710                 715                 720 
Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe Cys Ala Leu
                725                 730                 735     
Ser Thr Val Leu Glu Arg Val Lys Ala Glu Gly Ile Leu Asp Val Phe
            740                 745                 750         
Gln Thr Val Lys Ser Leu Arg Leu Gln Arg Pro His Met Val Gln Thr
        755                 760                 765             
Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Glu Tyr Ile Asp
    770                 775                 780                 
Ala Phe Ser Asp Tyr Ala Asn Phe Lys
785                 790             


<210> 6422
<211> 1099
<212> PRT
<213> Homo sapiens

<400> 6422
Met Gly Lys Leu Ile Arg Met Gly Pro Gln Glu Arg Trp Leu Leu Arg
 1               5                  10                  15      
Thr Lys Arg Leu His Trp Ser Arg Leu Leu Phe Leu Leu Gly Met Leu
            20                  25                  30          
Ile Ile Gly Ser Thr Tyr Gln His Leu Arg Arg Pro Arg Gly Leu Ser
        35                  40                  45              
Ser Leu Trp Ala Ala Val Ser Ser His Gln Pro Ile Lys Leu Ala Ser
    50                  55                  60                  
Arg Asp Leu Ser Ser Glu Glu Met Met Met Met Ser Ser Ser Pro Ser
65                  70                  75                  80  
Lys Pro Ser Ser Glu Met Gly Gly Lys Met Leu Val Pro Gln Ala Ser
                85                  90                  95      
Val Gly Ser Asp Glu Ala Thr Leu Ser Met Thr Val Glu Asn Ile Pro
            100                 105                 110         
Ser Met Pro Lys Arg Thr Ala Lys Met Ile Pro Thr Thr Thr Lys Asn
        115                 120                 125             
Asn Tyr Ser Pro Thr Ala Ala Gly Thr Glu Arg Arg Lys Glu Asp Thr
    130                 135                 140                 
Pro Thr Ser Ser Arg Thr Leu Thr Tyr Tyr Thr Ser Thr Ser Ser Arg
145                 150                 155                 160 
Gln Ile Val Lys Lys Tyr Thr Pro Thr Pro Arg Gly Glu Met Lys Ser
                165                 170                 175     
Tyr Ser Pro Thr Gln Val Arg Glu Lys Val Lys Tyr Thr Pro Ser Pro
            180                 185                 190         
Arg Gly Arg Arg Val Gly Thr Tyr Val Pro Ser Thr Phe Met Thr Met
        195                 200                 205             
Glu Thr Ser His Ala Ile Thr Pro Arg Thr Thr Val Lys Asp Ser Asp
    210                 215                 220                 
Ile Thr Ala Thr Tyr Lys Ile Leu Glu Thr Asn Ser Leu Lys Arg Ile
225                 230                 235                 240 
Met Glu Glu Thr Thr Pro Thr Thr Leu Lys Gly Met Phe Asp Ser Thr
                245                 250                 255     
Pro Thr Phe Leu Thr His Glu Val Glu Ala Asn Val Leu Thr Ser Pro
            260                 265                 270         
Arg Ser Val Met Glu Lys Asn Asn Leu Phe Pro Pro Arg Arg Val Glu
        275                 280                 285             
Ser Asn Ser Ser Ala His Pro Trp Gly Leu Val Gly Lys Ser Asn Pro
    290                 295                 300                 
Lys Thr Pro Gln Gly Thr Val Leu Leu His Thr Pro Ala Thr Ser Glu
305                 310                 315                 320 
Gly Gln Val Thr Ile Ser Thr Met Thr Gly Ser Ser Pro Ala Glu Thr
                325                 330                 335     
Lys Ala Phe Thr Ala Ala Trp Ser Leu Arg Asn Pro Ser Pro Arg Thr
            340                 345                 350         
Ser Val Ser Ala Ile Lys Thr Ala Pro Ala Ile Val Trp Arg Leu Ala
        355                 360                 365             
Lys Lys Pro Ser Thr Ala Pro Ser Thr Ser Thr Thr Pro Thr Val Arg
    370                 375                 380                 
Ala Lys Leu Thr Met Gln Val His His Cys Val Val Val Lys Pro Thr
385                 390                 395                 400 
Pro Ala Met Leu Thr Thr Pro Ser Pro Ser Leu Thr Thr Ala Leu Leu
                405                 410                 415     
Pro Glu Glu Leu Ser Pro Ser Pro Ser Val Leu Pro Pro Ser Leu Pro
            420                 425                 430         
Asp Leu His Pro Lys Gly Glu Tyr Pro Pro Asp Leu Phe Ser Val Glu
        435                 440                 445             
Glu Arg Arg Gln Gly Trp Val Val Leu His Val Phe Gly Met Met Tyr
    450                 455                 460                 
Val Phe Val Ala Leu Ala Ile Val Cys Asp Glu Tyr Phe Val Pro Ala
465                 470                 475                 480 
Leu Gly Val Ile Thr Asp Lys Leu Gln Ile Ser Glu Asp Val Ala Gly
                485                 490                 495     
Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser
            500                 505                 510         
Leu Ile Gly Val Phe Ile Ser His Ser Asn Val Gly Ile Gly Thr Ile
        515                 520                 525             
Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Thr Cys Ser
    530                 535                 540                 
Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg
545                 550                 555                 560 
Asp Val Ser Phe Tyr Ile Leu Asp Leu Ile Met Leu Ile Leu Phe Phe
                565                 570                 575     
Leu Asp Ser Leu Ile Ala Trp Trp Glu Ser Leu Leu Leu Leu Leu Ala
            580                 585                 590         
Tyr Ala Phe Tyr Val Phe Thr Met Lys Trp Asn Lys His Ile Glu Val
        595                 600                 605             
Trp Val Lys Glu Gln Leu Ser Arg Arg Pro Val Ala Lys Val Met Ala
    610                 615                 620                 
Leu Glu Asp Leu Ser Lys Pro Gly Asp Gly Ala Ile Ala Val Asp Glu
625                 630                 635                 640 
Leu Gln Asp Asn Lys Lys Leu Lys Leu Pro Ser Leu Leu Thr Arg Gly
                645                 650                 655     
Ser Ser Ser Thr Ser Leu His Asn Ser Thr Ile Arg Ser Thr Ile Tyr
            660                 665                 670         
Gln Leu Met Leu His Ser Leu Asp Pro Leu Arg Glu Val Arg Leu Ala
        675                 680                 685             
Lys Glu Lys Glu Glu Glu Ser Leu Asn Gln Gly Ala Arg Ala Gln Pro
    690                 695                 700                 
Gln Ala Lys Ala Glu Ser Lys Pro Glu Glu Glu Glu Pro Ala Lys Leu
705                 710                 715                 720 
Pro Ala Val Thr Val Thr Pro Ala Pro Val Pro Asp Ile Lys Gly Asp
                725                 730                 735     
Gln Lys Glu Asn Pro Gly Gly Gln Glu Asp Val Ala Glu Ala Glu Ser
            740                 745                 750         
Thr Gly Glu Met Pro Gly Glu Glu Gly Glu Thr Ala Gly Glu Gly Glu
        755                 760                 765             
Thr Glu Glu Lys Ser Gly Gly Glu Thr Gln Pro Glu Gly Glu Gly Glu
    770                 775                 780                 
Thr Glu Thr Gln Gly Lys Gly Glu Glu Cys Glu Asp Glu Asn Glu Ala
785                 790                 795                 800 
Glu Gly Lys Gly Asp Asn Glu Gly Glu Asp Glu Gly Glu Ile His Ala
                805                 810                 815     
Glu Asp Gly Glu Met Lys Gly Asn Glu Gly Glu Thr Glu Ser Gln Glu
            820                 825                 830         
Leu Ser Ala Glu Asn His Gly Glu Ala Lys Asn Asp Glu Lys Gly Val
        835                 840                 845             
Glu Asp Gly Gly Gly Ser Asp Gly Gly Asp Ser Glu Glu Glu Glu Glu
    850                 855                 860                 
Glu Glu Glu Glu Gln Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu
865                 870                 875                 880 
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Gly Asn Glu Glu Pro
                885                 890                 895     
Leu Ser Leu Asp Trp Pro Glu Thr Arg Gln Lys Gln Ala Ile Tyr Leu
            900                 905                 910         
Phe Leu Leu Pro Ile Val Phe Pro Leu Trp Leu Thr Val Pro Asp Val
        915                 920                 925             
Arg Arg Gln Glu Ser Arg Lys Phe Phe Val Phe Thr Phe Leu Gly Ser
    930                 935                 940                 
Ile Met Trp Ile Ala Met Phe Ser Tyr Leu Met Val Trp Trp Ala His
945                 950                 955                 960 
Gln Val Gly Glu Thr Ile Gly Ile Ser Glu Glu Ile Met Gly Leu Thr
                965                 970                 975     
Ile Leu Ala Ala Gly Thr Ser Ile Pro Asp Leu Ile Thr Ser Val Ile
            980                 985                 990         
Val Ala Arg Lys Gly Leu Gly Asp Met Ala Val Ser Ser Ser Val Gly
        995                 1000                1005            
Ser Asn Ile Phe Asp Ile Thr Val Gly Leu Pro Val Pro Trp Leu Leu
    1010                1015                1020                
Phe Ser Leu Ile Asn Gly Leu Gln Pro Val Pro Val Ser Ser Asn Gly
1025                1030                1035                1040
Leu Phe Cys Ala Ile Val Leu Leu Phe Leu Met Leu Leu Phe Val Ile
                1045                1050                1055    
Ser Ser Ile Ala Ser Cys Lys Trp Arg Met Asn Lys Ile Leu Gly Phe
            1060                1065                1070        
Thr Met Phe Leu Leu Tyr Phe Val Phe Leu Ile Ile Ser Val Met Leu
        1075                1080                1085            
Glu Asp Arg Ile Ile Ser Cys Pro Val Ser Val
    1090                1095                


<210> 6423
<211> 1081
<212> PRT
<213> Homo sapiens

<400> 6423
Met Gly Lys Leu Ile Arg Met Gly Pro Gln Glu Arg Trp Leu Leu Arg
 1               5                  10                  15      
Thr Lys Arg Leu His Trp Ser Arg Leu Leu Phe Leu Leu Gly Met Leu
            20                  25                  30          
Ile Ile Gly Ser Thr Tyr Gln His Leu Arg Arg Pro Arg Gly Leu Ser
        35                  40                  45              
Ser Leu Trp Ala Ala Val Ser Ser His Gln Pro Ile Lys Leu Ala Ser
    50                  55                  60                  
Arg Asp Leu Ser Ser Glu Glu Met Met Met Met Ser Ser Ser Pro Ser
65                  70                  75                  80  
Lys Pro Ser Ser Glu Met Gly Gly Lys Met Leu Val Pro Gln Ala Ser
                85                  90                  95      
Val Gly Ser Asp Glu Ala Thr Leu Ser Met Thr Val Glu Asn Ile Pro
            100                 105                 110         
Ser Met Pro Lys Arg Thr Ala Lys Met Ile Pro Thr Thr Thr Lys Asn
        115                 120                 125             
Asn Tyr Ser Pro Thr Ala Ala Gly Thr Glu Arg Arg Lys Glu Asp Thr
    130                 135                 140                 
Pro Thr Ser Ser Arg Thr Leu Thr Tyr Tyr Thr Ser Thr Ser Ser Arg
145                 150                 155                 160 
Gln Ile Val Lys Lys Tyr Thr Pro Thr Pro Arg Gly Glu Met Lys Ser
                165                 170                 175     
Tyr Ser Pro Thr Gln Val Arg Glu Lys Val Lys Tyr Thr Pro Ser Pro
            180                 185                 190         
Arg Gly Arg Arg Val Gly Thr Tyr Val Pro Ser Thr Phe Met Thr Met
        195                 200                 205             
Glu Thr Ser His Ala Ile Thr Pro Arg Thr Thr Val Lys Asp Ser Asp
    210                 215                 220                 
Ile Thr Ala Thr Tyr Lys Ile Leu Glu Thr Asn Ser Leu Lys Arg Ile
225                 230                 235                 240 
Met Glu Glu Thr Thr Pro Thr Thr Leu Lys Gly Met Phe Asp Ser Thr
                245                 250                 255     
Pro Thr Phe Leu Thr His Glu Val Glu Ala Asn Val Leu Thr Ser Pro
            260                 265                 270         
Arg Ser Val Met Glu Lys Asn Asn Leu Phe Pro Pro Arg Arg Val Glu
        275                 280                 285             
Ser Asn Ser Ser Ala His Pro Trp Gly Leu Val Gly Lys Ser Asn Pro
    290                 295                 300                 
Lys Thr Pro Gln Gly Thr Val Leu Leu His Thr Pro Ala Thr Ser Glu
305                 310                 315                 320 
Gly Gln Val Thr Ile Ser Thr Met Thr Gly Ser Ser Pro Ala Glu Thr
                325                 330                 335     
Lys Ala Phe Thr Ala Ala Trp Ser Leu Arg Asn Pro Ser Pro Arg Thr
            340                 345                 350         
Ser Val Ser Ala Ile Lys Thr Ala Pro Ala Ile Val Trp Arg Leu Ala
        355                 360                 365             
Lys Lys Pro Ser Thr Ala Pro Ser Thr Ser Thr Thr Pro Thr Val Arg
    370                 375                 380                 
Ala Lys Leu Thr Met Gln Val His His Cys Val Val Val Lys Pro Thr
385                 390                 395                 400 
Pro Ala Met Leu Thr Thr Pro Ser Pro Ser Leu Thr Thr Ala Leu Leu
                405                 410                 415     
Pro Glu Glu Leu Ser Pro Ser Pro Ser Val Leu Pro Pro Ser Leu Pro
            420                 425                 430         
Asp Leu His Pro Lys Gly Glu Tyr Pro Pro Asp Leu Phe Ser Val Glu
        435                 440                 445             
Glu Arg Arg Gln Gly Trp Val Val Leu His Val Phe Gly Met Met Tyr
    450                 455                 460                 
Val Phe Val Ala Leu Ala Ile Val Cys Asp Glu Tyr Phe Val Pro Ala
465                 470                 475                 480 
Leu Gly Val Ile Thr Asp Lys Leu Gln Ile Ser Glu Asp Val Ala Gly
                485                 490                 495     
Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser
            500                 505                 510         
Leu Ile Gly Val Phe Ile Ser His Ser Asn Val Gly Ile Gly Thr Ile
        515                 520                 525             
Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Thr Cys Ser
    530                 535                 540                 
Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg
545                 550                 555                 560 
Asp Val Ser Phe Tyr Ile Leu Asp Leu Ile Met Leu Ile Leu Phe Phe
                565                 570                 575     
Leu Asp Ser Leu Ile Ala Trp Trp Glu Ser Leu Leu Leu Leu Leu Ala
            580                 585                 590         
Tyr Ala Phe Tyr Val Phe Thr Met Lys Trp Asn Lys His Ile Glu Val
        595                 600                 605             
Trp Val Lys Glu Gln Leu Ser Arg Arg Pro Val Ala Lys Val Met Ala
    610                 615                 620                 
Leu Glu Asp Leu Ser Lys Leu Pro Ser Leu Leu Thr Arg Gly Ser Ser
625                 630                 635                 640 
Ser Thr Ser Leu His Asn Ser Thr Ile Arg Ser Thr Ile Tyr Gln Leu
                645                 650                 655     
Met Leu His Ser Leu Asp Pro Leu Arg Glu Val Arg Leu Ala Lys Glu
            660                 665                 670         
Lys Glu Glu Glu Ser Leu Asn Gln Gly Ala Arg Ala Gln Pro Gln Ala
        675                 680                 685             
Lys Ala Glu Ser Lys Pro Glu Glu Glu Glu Pro Ala Lys Leu Pro Ala
    690                 695                 700                 
Val Thr Val Thr Pro Ala Pro Val Pro Asp Ile Lys Gly Asp Gln Lys
705                 710                 715                 720 
Glu Asn Pro Gly Gly Gln Glu Asp Val Ala Glu Ala Glu Ser Thr Gly
                725                 730                 735     
Glu Met Pro Gly Glu Glu Gly Glu Thr Ala Gly Glu Gly Glu Thr Glu
            740                 745                 750         
Glu Lys Ser Gly Gly Glu Thr Gln Pro Glu Gly Glu Gly Glu Thr Glu
        755                 760                 765             
Thr Gln Gly Lys Gly Glu Glu Cys Glu Asp Glu Asn Glu Ala Glu Gly
    770                 775                 780                 
Lys Gly Asp Asn Glu Gly Glu Asp Glu Gly Glu Ile His Ala Glu Asp
785                 790                 795                 800 
Gly Glu Met Lys Gly Asn Glu Gly Glu Thr Glu Ser Gln Glu Leu Ser
                805                 810                 815     
Ala Glu Asn His Gly Glu Ala Lys Asn Asp Glu Lys Gly Val Glu Asp
            820                 825                 830         
Gly Gly Gly Ser Asp Gly Gly Asp Ser Glu Glu Glu Glu Glu Glu Glu
        835                 840                 845             
Glu Glu Gln Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu Glu Glu
    850                 855                 860                 
Glu Glu Glu Glu Glu Glu Glu Glu Lys Gly Asn Glu Glu Pro Leu Ser
865                 870                 875                 880 
Leu Asp Trp Pro Glu Thr Arg Gln Lys Gln Ala Ile Tyr Leu Phe Leu
                885                 890                 895     
Leu Pro Ile Val Phe Pro Leu Trp Leu Thr Val Pro Asp Val Arg Arg
            900                 905                 910         
Gln Glu Ser Arg Lys Phe Phe Val Phe Thr Phe Leu Gly Ser Ile Met
        915                 920                 925             
Trp Ile Ala Met Phe Ser Tyr Leu Met Val Trp Trp Ala His Gln Val
    930                 935                 940                 
Gly Glu Thr Ile Gly Ile Ser Glu Glu Ile Met Gly Leu Thr Ile Leu
945                 950                 955                 960 
Ala Ala Gly Thr Ser Ile Pro Asp Leu Ile Thr Ser Val Ile Val Ala
                965                 970                 975     
Arg Lys Gly Leu Gly Asp Met Ala Val Ser Ser Ser Val Gly Ser Asn
            980                 985                 990         
Ile Phe Asp Ile Thr Val Gly Leu Pro Val Pro Trp Leu Leu Phe Ser
        995                 1000                1005            
Leu Ile Asn Gly Leu Gln Pro Val Pro Val Ser Ser Asn Gly Leu Phe
    1010                1015                1020                
Cys Ala Ile Val Leu Leu Phe Leu Met Leu Leu Phe Val Ile Ser Ser
1025                1030                1035                1040
Ile Ala Ser Cys Lys Trp Arg Met Asn Lys Ile Leu Gly Phe Thr Met
                1045                1050                1055    
Phe Leu Leu Tyr Phe Val Phe Leu Ile Ile Ser Val Met Leu Glu Asp
            1060                1065                1070        
Arg Ile Ile Ser Cys Pro Val Ser Val
        1075                1080    


<210> 6424
<211> 224
<212> PRT
<213> Homo sapiens

<400> 6424
Met Arg Leu Trp Lys Ala Arg Val Leu Lys Leu Val Leu Lys Thr Ala
 1               5                  10                  15      
Lys Asp Ser Arg Leu Gly Leu Asn Ser Lys Trp Leu Ser Leu Lys Leu
            20                  25                  30          
Gly Asp Ala Gly Asn Pro Arg Ser Leu Ala Ile Arg Phe Ile Leu Thr
        35                  40                  45              
Asn Tyr Asn Lys Leu Ser Ile Gln Ser Trp Phe Ser Leu Arg Arg Val
    50                  55                  60                  
Glu Ile Ile Ser Asn Asn Ser Ile Gln Ala Val Phe Asn Pro Thr Gly
65                  70                  75                  80  
Val Tyr Ala Pro Ser Gly Tyr Ser Tyr Arg Cys Gln Arg Val Gly Ser
                85                  90                  95      
Leu Gln Gln Asp Gln Ala Leu Leu Leu Pro Ser Asp Thr Asp Asp Gly
            100                 105                 110         
Ser Ser Leu Trp Glu Val Thr Phe Ile Asp Phe Gln Ile Gln Gly Phe
        115                 120                 125             
Ala Ile Lys Gly Gly Arg Phe Thr Lys Ala Gln Asp Cys Ala Ser Ser
    130                 135                 140                 
Phe Ser Pro Ala Phe Leu Ile Gly Leu Ala Met Ser Leu Ile Leu Leu
145                 150                 155                 160 
Leu Val Leu Ala Tyr Ala Leu His Met Leu Ile Tyr Leu Arg Tyr Leu
                165                 170                 175     
Asp Gln Gln Tyr Asp Leu Ile Ala Ser Pro Ala His Phe Ser Gln Leu
            180                 185                 190         
Lys Ala Arg Asp Thr Ala Glu Glu Lys Glu Leu Leu Arg Ser Gln Gly
        195                 200                 205             
Ala Glu Cys Tyr Lys Leu Arg Ser Gln Gln Ile Ser Lys Ile Tyr Val
    210                 215                 220                 


<210> 6425
<211> 2050
<212> PRT
<213> Homo sapiens

<400> 6425
Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys
 1               5                  10                  15      
Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys
            20                  25                  30          
Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu
        35                  40                  45              
Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser
    50                  55                  60                  
Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu
65                  70                  75                  80  
Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser
                85                  90                  95      
Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln
            100                 105                 110         
Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser
        115                 120                 125             
Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly
    130                 135                 140                 
Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala
145                 150                 155                 160 
Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala
                165                 170                 175     
Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu
            180                 185                 190         
Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly
        195                 200                 205             
Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val
    210                 215                 220                 
Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe
225                 230                 235                 240 
Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu
                245                 250                 255     
Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg
            260                 265                 270         
Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr
        275                 280                 285             
Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp
    290                 295                 300                 
Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met
305                 310                 315                 320 
Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg
                325                 330                 335     
Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly
            340                 345                 350         
Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu
        355                 360                 365             
Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile
    370                 375                 380                 
Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu
385                 390                 395                 400 
Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn
                405                 410                 415     
Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro
            420                 425                 430         
Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu
        435                 440                 445             
Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile
    450                 455                 460                 
Ala Ala Ser Gly Gly Glu Val Glu Asp Phe Ser Ser Ser Gly Thr Gly
465                 470                 475                 480 
Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu Thr Glu Val Gly Phe Val
                485                 490                 495     
Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser Pro Arg Glu
            500                 505                 510         
Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr Gly Lys Gly
        515                 520                 525             
Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu Ala Thr Phe
    530                 535                 540                 
Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile Ser Asn Asp
545                 550                 555                 560 
Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys Tyr Ser Leu
                565                 570                 575     
Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val Gly Glu Ala
            580                 585                 590         
Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp Thr
        595                 600                 605             
Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val Phe
    610                 615                 620                 
Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr Lys Pro Val
625                 630                 635                 640 
Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg Leu Asp Ala
                645                 650                 655     
Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr Asn Ile Glu
            660                 665                 670         
Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn Gln Leu Ala
        675                 680                 685             
Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp Thr Arg Tyr
    690                 695                 700                 
Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val Leu Asp Thr
705                 710                 715                 720 
Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile His Glu Ala
                725                 730                 735     
Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser Thr Leu Ala
            740                 745                 750         
Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr Glu Glu Pro
        755                 760                 765             
Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg Gly Glu Lys
    770                 775                 780                 
Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu Tyr Ser Thr
785                 790                 795                 800 
Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr Gln Thr Ile
                805                 810                 815     
Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys Val Pro Val
            820                 825                 830         
Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val Glu Lys Lys
        835                 840                 845             
Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala Glu Met Tyr
    850                 855                 860                 
Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser Gly Leu Val
865                 870                 875                 880 
Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu Lys Arg
                885                 890                 895     
Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly Glu Trp Ile
            900                 905                 910         
Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala Gly His Thr
        915                 920                 925             
Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr Pro Gly Gly
    930                 935                 940                 
Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn Gly Asp Lys
945                 950                 955                 960 
Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp Glu Trp Glu
                965                 970                 975     
Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp Glu Lys Gly
            980                 985                 990         
Trp Glu Tyr Gly Ile Thr Ile Pro Pro Asp His Lys Pro Lys Ser Trp
        995                 1000                1005            
Val Ala Ala Glu Lys Met Tyr His Thr His Arg Arg Arg Arg Leu Val
    1010                1015                1020                
Arg Lys Arg Lys Lys Asp Leu Thr Gln Thr Ala Ser Ser Thr Ala Arg
1025                1030                1035                1040
Ala Met Glu Glu Leu Gln Asp Gln Glu Gly Trp Glu Tyr Ala Ser Leu
                1045                1050                1055    
Ile Gly Trp Lys Phe His Trp Lys Gln Arg Ser Ser Asp Thr Phe Arg
            1060                1065                1070        
Arg Arg Arg Trp Arg Arg Lys Met Ala Pro Ser Glu Thr His Gly Ala
        1075                1080                1085            
Ala Ala Ile Phe Lys Leu Glu Gly Ala Leu Gly Ala Asp Thr Thr Glu
    1090                1095                1100                
Asp Gly Asp Glu Lys Ser Leu Glu Lys Gln Lys His Ser Ala Thr Thr
1105                1110                1115                1120
Val Phe Gly Ala Asn Thr Pro Ile Val Ser Cys Asn Phe Asp Arg Val
                1125                1130                1135    
Tyr Ile Tyr His Leu Arg Cys Tyr Val Tyr Gln Ala Arg Asn Leu Leu
            1140                1145                1150        
Ala Leu Asp Lys Asp Ser Phe Ser Asp Pro Tyr Ala His Ile Cys Phe
        1155                1160                1165            
Leu His Arg Ser Lys Thr Thr Glu Ile Ile His Ser Thr Leu Asn Pro
    1170                1175                1180                
Thr Trp Asp Gln Thr Ile Ile Phe Asp Glu Val Glu Ile Tyr Gly Glu
1185                1190                1195                1200
Pro Gln Thr Val Leu Gln Asn Pro Pro Lys Val Ile Met Glu Leu Phe
                1205                1210                1215    
Asp Asn Asp Gln Val Gly Lys Asp Glu Phe Leu Gly Arg Ser Ile Phe
            1220                1225                1230        
Ser Pro Val Val Lys Leu Asn Ser Glu Met Asp Ile Thr Pro Lys Leu
        1235                1240                1245            
Leu Trp His Pro Val Met Asn Gly Asp Lys Ala Cys Gly Asp Val Leu
    1250                1255                1260                
Val Thr Ala Glu Leu Ile Leu Arg Gly Lys Asp Gly Ser Asn Leu Pro
1265                1270                1275                1280
Ile Leu Pro Pro Gln Arg Ala Pro Asn Leu Tyr Met Val Pro Gln Gly
                1285                1290                1295    
Ile Arg Pro Val Val Gln Leu Thr Ala Ile Glu Ile Leu Ala Trp Gly
            1300                1305                1310        
Leu Arg Asn Met Lys Asn Phe Gln Met Ala Ser Ile Thr Ser Pro Ser
        1315                1320                1325            
Leu Val Val Glu Cys Gly Gly Glu Arg Val Glu Ser Val Val Ile Lys
    1330                1335                1340                
Asn Leu Lys Lys Thr Pro Asn Phe Pro Ser Ser Val Leu Phe Met Lys
1345                1350                1355                1360
Val Phe Leu Pro Lys Glu Glu Leu Tyr Met Pro Pro Leu Val Ile Lys
                1365                1370                1375    
Val Ile Asp His Arg Gln Phe Gly Arg Lys Pro Val Val Gly Gln Cys
            1380                1385                1390        
Thr Ile Glu Arg Leu Asp Arg Phe Arg Cys Asp Pro Tyr Ala Gly Lys
        1395                1400                1405            
Glu Asp Ile Val Pro Gln Leu Lys Ala Ser Leu Leu Ser Ala Pro Pro
    1410                1415                1420                
Cys Arg Asp Ile Val Ile Glu Met Glu Asp Thr Lys Pro Leu Leu Ala
1425                1430                1435                1440
Ser Lys Cys Leu Ser Ser Met Ser Thr Ala Leu Ser Lys Met Ala Ser
                1445                1450                1455    
Pro Ala Thr Val His Leu Thr Glu Lys Glu Glu Glu Ile Val Asp Trp
            1460                1465                1470        
Trp Ser Lys Phe Tyr Ala Ser Ser Gly Glu His Glu Lys Cys Gly Gln
        1475                1480                1485            
Tyr Ile Gln Lys Gly Tyr Ser Lys Leu Lys Ile Tyr Asn Cys Glu Leu
    1490                1495                1500                
Glu Asn Val Ala Glu Phe Glu Gly Leu Thr Asp Phe Ser Asp Thr Phe
1505                1510                1515                1520
Lys Leu Tyr Arg Gly Lys Ser Asp Glu Asn Glu Asp Pro Ser Val Val
                1525                1530                1535    
Gly Glu Phe Lys Gly Ser Phe Arg Ile Tyr Pro Leu Pro Asp Asp Pro
            1540                1545                1550        
Ser Val Pro Ala Pro Pro Arg Gln Phe Arg Glu Leu Pro Asp Ser Val
        1555                1560                1565            
Pro Gln Glu Cys Thr Val Arg Ile Tyr Ile Val Arg Gly Leu Glu Leu
    1570                1575                1580                
Gln Pro Gln Asp Asn Asn Gly Leu Cys Asp Pro Tyr Ile Lys Ile Thr
1585                1590                1595                1600
Leu Gly Lys Lys Val Ile Glu Asp Arg Asp His Tyr Ile Pro Asn Thr
                1605                1610                1615    
Leu Asn Pro Val Phe Gly Arg Met Tyr Glu Leu Ser Cys Tyr Leu Pro
            1620                1625                1630        
Gln Glu Lys Asp Leu Lys Ile Ser Val Tyr Asp Tyr Asp Thr Phe Thr
        1635                1640                1645            
Arg Asp Glu Lys Val Gly Glu Thr Ile Ile Asp Leu Glu Asn Arg Phe
    1650                1655                1660                
Leu Ser Arg Phe Gly Ser His Cys Gly Ile Pro Glu Glu Tyr Cys Val
1665                1670                1675                1680
Ser Gly Val Asn Thr Trp Arg Asp Gln Leu Arg Pro Thr Gln Leu Leu
                1685                1690                1695    
Gln Asn Val Ala Arg Phe Lys Gly Phe Pro Gln Pro Ile Leu Ser Glu
            1700                1705                1710        
Asp Gly Ser Arg Ile Arg Tyr Gly Gly Arg Asp Tyr Ser Leu Asp Glu
        1715                1720                1725            
Phe Glu Ala Asn Lys Ile Leu His Gln His Leu Gly Ala Pro Glu Glu
    1730                1735                1740                
Arg Leu Ala Leu His Ile Leu Arg Thr Gln Gly Leu Val Pro Glu His
1745                1750                1755                1760
Val Glu Thr Arg Thr Leu His Ser Thr Phe Gln Pro Asn Ile Ser Arg
                1765                1770                1775    
Tyr Tyr Leu Arg Val Ile Ile Trp Asn Thr Lys Asp Val Ile Leu Asp
            1780                1785                1790        
Glu Lys Ser Ile Thr Gly Glu Glu Met Ser Asp Ile Tyr Val Lys Gly
        1795                1800                1805            
Trp Ile Pro Gly Asn Glu Glu Asn Lys Gln Lys Thr Asp Val His Tyr
    1810                1815                1820                
Arg Ser Leu Asp Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Pro
1825                1830                1835                1840
Phe Asp Tyr Leu Pro Ala Glu Gln Leu Cys Ile Val Ala Lys Lys Glu
                1845                1850                1855    
His Phe Trp Ser Ile Asp Gln Thr Glu Phe Arg Ile Pro Pro Arg Leu
            1860                1865                1870        
Ile Ile Gln Ile Trp Asp Asn Asp Lys Phe Ser Leu Asp Asp Tyr Leu
        1875                1880                1885            
Gly Phe Leu Glu Leu Asp Leu Arg His Thr Ile Ile Pro Ala Lys Ser
    1890                1895                1900                
Pro Glu Lys Cys Arg Leu Asp Met Ile Pro Asp Leu Lys Ala Met Asn
1905                1910                1915                1920
Pro Leu Lys Ala Lys Thr Ala Ser Leu Phe Glu Gln Lys Ser Met Lys
                1925                1930                1935    
Gly Trp Trp Pro Cys Tyr Ala Glu Lys Asp Gly Ala Arg Val Met Ala
            1940                1945                1950        
Gly Lys Val Glu Met Thr Leu Glu Ile Leu Asn Glu Lys Glu Ala Asp
        1955                1960                1965            
Glu Arg Pro Ala Gly Lys Gly Arg Asp Glu Pro Asn Met Asn Pro Lys
    1970                1975                1980                
Leu Asp Leu Pro Asn Arg Pro Glu Thr Ser Phe Leu Trp Phe Thr Asn
1985                1990                1995                2000
Pro Cys Lys Thr Met Lys Phe Ile Val Trp Arg Arg Phe Lys Trp Val
                2005                2010                2015    
Ile Ile Gly Leu Leu Phe Leu Leu Ile Leu Leu Leu Phe Val Ala Val
            2020                2025                2030        
Leu Leu Tyr Ser Leu Pro Asn Tyr Leu Ser Met Lys Ile Val Lys Pro
        2035                2040                2045            
Asn Val
    2050


<210> 6426
<211> 311
<212> PRT
<213> Homo sapiens

<400> 6426
Met Lys Ile Phe Asn Ser Pro Ser Asn Ser Ser Thr Phe Thr Gly Phe
 1               5                  10                  15      
Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu Leu Phe
            20                  25                  30          
Val Leu Phe Thr Val Val Tyr Leu Leu Thr Leu Met Gly Asn Gly Ser
        35                  40                  45              
Ile Ile Cys Ala Val His Trp Asp Gln Arg Leu His Ala Pro Met Tyr
    50                  55                  60                  
Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val Thr Ser
65                  70                  75                  80  
Thr Val Pro Ser Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Ile Ile
                85                  90                  95      
Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly
            100                 105                 110         
Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg Tyr Leu
        115                 120                 125             
Ala Ile Cys Arg Pro Leu Arg Tyr Pro Thr Ile Met Thr Arg Arg Leu
    130                 135                 140                 
Cys Thr Asn Leu Val Val Asn Cys Trp Val Leu Gly Phe Ile Trp Phe
145                 150                 155                 160 
Leu Ile Pro Ile Val Asn Ile Ser Gln Met Ser Phe Cys Gly Ser Arg
                165                 170                 175     
Ile Ile Asp His Phe Leu Cys Asp Pro Ala Pro Leu Leu Thr Leu Thr
            180                 185                 190         
Cys Lys Lys Gly Pro Val Ile Glu Leu Val Phe Ser Val Leu Ser Pro
        195                 200                 205             
Leu Pro Val Phe Met Leu Phe Leu Phe Ile Val Gly Ser Tyr Ala Leu
    210                 215                 220                 
Val Val Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg Arg Lys
225                 230                 235                 240 
Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr
                245                 250                 255     
Gly Ser Val Leu Val Met Tyr Gly Ser Pro Pro Ser Lys Asn Glu Ala
            260                 265                 270         
Gly Lys Gln Lys Thr Val Thr Leu Phe Tyr Ser Val Val Thr Pro Leu
        275                 280                 285             
Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Arg Lys Ala
    290                 295                 300                 
Leu Lys Lys Phe Trp Gly Thr
305                 310     


<210> 6427
<211> 927
<212> PRT
<213> Homo sapiens

<400> 6427
Met Gln Arg Ala Arg Glu Ala Glu Met Met Lys Ser Gln Val Leu Phe
 1               5                  10                  15      
Pro Phe Leu Leu Ser Leu Phe Cys Gly Ala Ile Ser Gln Gln Ile Arg
            20                  25                  30          
Tyr Thr Ile Pro Glu Glu Leu Ala Asn Gly Ser Arg Val Gly Lys Leu
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Ser Val Arg Glu Leu Pro Thr Arg Lys Leu
    50                  55                  60                  
Arg Val Ser Ala Glu Asp Tyr Phe Asn Val Ser Leu Glu Ser Gly Asp
65                  70                  75                  80  
Leu Leu Val Asn Gly Arg Ile Asp Arg Glu Lys Ile Cys Gly Arg Lys
                85                  90                  95      
Leu Glu Cys Ala Leu Glu Phe Glu Thr Val Ala Glu Asn Pro Met Asn
            100                 105                 110         
Val Phe His Val Val Val Val Ile Gln Asp Ile Asn Asp Asn Ala Pro
        115                 120                 125             
Arg Phe Val Ala Lys Gly Ile Asp Leu Glu Ile Cys Glu Ser Ala Leu
    130                 135                 140                 
Pro Gly Val Lys Phe Ser Leu Asp Ser Ala Gln Asp Ala Asp Val Glu
145                 150                 155                 160 
Gly Asn Ser Leu Lys Leu Tyr Thr Ile Asn Pro Asn Gln Tyr Phe Ser
                165                 170                 175     
Leu Ser Thr Lys Glu Ser Pro Asp Gly Ser Lys Tyr Pro Val Leu Leu
            180                 185                 190         
Leu Glu Lys Pro Leu Asp Arg Glu His Gln Ser Ser His Arg Leu Ile
        195                 200                 205             
Leu Thr Ala Met Asp Gly Gly Asp Pro Pro Leu Ser Gly Thr Thr His
    210                 215                 220                 
Ile Trp Ile Arg Val Thr Asp Ala Asn Asp Asn Ala Pro Val Phe Ser
225                 230                 235                 240 
Gln Glu Val Tyr Arg Val Ser Leu Gln Glu Asn Val Pro Trp Gly Thr
                245                 250                 255     
Ser Val Leu Arg Val Met Ala Thr Asp Gln Asp Glu Gly Ile Asn Ala
            260                 265                 270         
Glu Ile Thr Tyr Ala Phe Leu Asn Ser Pro Ile Ser Thr Ser Leu Phe
        275                 280                 285             
Asn Leu Asn Pro Asn Thr Gly Asp Ile Thr Thr Asn Gly Thr Leu Asp
    290                 295                 300                 
Phe Glu Glu Thr Ser Arg Tyr Val Leu Ser Val Glu Ala Lys Asp Gly
305                 310                 315                 320 
Gly Val His Thr Ala His Cys Asn Val Gln Ile Glu Ile Val Asp Glu
                325                 330                 335     
Asn Asp Asn Ala Pro Glu Val Thr Phe Met Ser Phe Ser Asn Gln Ile
            340                 345                 350         
Pro Glu Asp Ser Asp Leu Gly Thr Val Ile Ala Leu Ile Lys Val Arg
        355                 360                 365             
Asp Lys Asp Ser Gly Gln Asn Gly Met Val Thr Cys Tyr Thr Gln Glu
    370                 375                 380                 
Glu Val Pro Phe Lys Leu Glu Ser Thr Ser Lys Asn Tyr Tyr Lys Leu
385                 390                 395                 400 
Val Ile Ala Gly Ala Leu Asn Arg Glu Gln Thr Ala Asp Tyr Asn Val
                405                 410                 415     
Thr Ile Ile Ala Thr Asp Lys Gly Lys Pro Ala Leu Ser Ser Arg Thr
            420                 425                 430         
Ser Ile Thr Leu His Ile Ser Asp Ile Asn Asp Asn Ala Pro Val Phe
        435                 440                 445             
His Gln Ala Ser Tyr Val Val His Val Ser Glu Asn Asn Pro Pro Gly
    450                 455                 460                 
Ala Ser Ile Ala Gln Val Ser Ala Ser Asp Pro Asp Leu Gly Pro Asn
465                 470                 475                 480 
Gly Arg Val Ser Tyr Ser Ile Leu Ala Ser Asp Leu Glu Pro Arg Glu
                485                 490                 495     
Leu Leu Ser Tyr Val Ser Val Ser Pro Gln Ser Gly Val Val Phe Ala
            500                 505                 510         
Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe Glu Leu Thr Leu
        515                 520                 525             
Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala Asn Val Ser Leu
    530                 535                 540                 
Arg Val Leu Val Gly Asp Leu Asn Asp Asn Ala Pro Arg Val Leu Tyr
545                 550                 555                 560 
Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp Met Val Pro Arg
                565                 570                 575     
Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Ala
            580                 585                 590         
Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val Leu Gln Ala Ser
        595                 600                 605             
Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly Glu Val Arg Thr
    610                 615                 620                 
Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln Arg Leu Leu Val
625                 630                 635                 640 
Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala Thr Ala Thr Leu
                645                 650                 655     
His Leu Ile Phe Ala Asp Ser Leu Gln Glu Val Leu Pro Asp Leu Ser
            660                 665                 670         
Asp Arg Pro Glu Pro Ser Asp Pro Gln Thr Glu Leu Gln Phe Tyr Leu
        675                 680                 685             
Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu Leu Ala Val Ile
    690                 695                 700                 
Leu Ala Ile Ala Leu Arg Leu Arg Arg Ser Ser Ser Leu Asp Thr Glu
705                 710                 715                 720 
Gly Cys Phe Gln Thr Gly Leu Cys Ser Lys Ser Gly Pro Gly Val Pro
                725                 730                 735     
Pro Asn His Ser Glu Gly Thr Leu Pro Tyr Ser Tyr Asn Leu Cys Ile
            740                 745                 750         
Ala Ser His Ser Ala Lys Thr Glu Phe Asn Ser Leu Asn Leu Thr Pro
        755                 760                 765             
Glu Met Ala Pro Pro Gln Asp Leu Leu Cys Asp Asp Pro Ser Met Val
    770                 775                 780                 
Val Cys Ala Ser Asn Glu Asp His Lys Ile Ala Tyr Asp Pro Ser Leu
785                 790                 795                 800 
Ser Ser His Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala
                805                 810                 815     
Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr
            820                 825                 830         
Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu
        835                 840                 845             
Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly
    850                 855                 860                 
Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu
865                 870                 875                 880 
Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn
                885                 890                 895     
Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala
            900                 905                 910         
Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys
        915                 920                 925         


<210> 6428
<211> 935
<212> PRT
<213> Homo sapiens

<400> 6428
Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu
 1               5                  10                  15      
Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile
            20                  25                  30          
Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn
        35                  40                  45              
Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly
    50                  55                  60                  
Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro
65                  70                  75                  80  
Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu
                85                  90                  95      
Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu
            100                 105                 110         
Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn
        115                 120                 125             
Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser
    130                 135                 140                 
Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp
145                 150                 155                 160 
Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn
                165                 170                 175     
Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn
            180                 185                 190         
Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala
        195                 200                 205             
His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys
    210                 215                 220                 
Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile
225                 230                 235                 240 
Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile
                245                 250                 255     
Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu
            260                 265                 270         
Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys
        275                 280                 285             
Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val
    290                 295                 300                 
Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile
305                 310                 315                 320 
Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile
                325                 330                 335     
Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser
            340                 345                 350         
Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala
        355                 360                 365             
Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser
    370                 375                 380                 
Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly
385                 390                 395                 400 
Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val
                405                 410                 415     
Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro
            420                 425                 430         
Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp
        435                 440                 445             
Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu
    450                 455                 460                 
Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro
465                 470                 475                 480 
Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr
                485                 490                 495     
Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr
            500                 505                 510         
Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp
        515                 520                 525             
Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser
    530                 535                 540                 
Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala
545                 550                 555                 560 
Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val
                565                 570                 575     
Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val
            580                 585                 590         
Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg
        595                 600                 605             
Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr
    610                 615                 620                 
Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys
625                 630                 635                 640 
Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser
                645                 650                 655     
Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val
            660                 665                 670         
Leu Ala Asp Leu Gly Ser Leu Glu Ser Leu Ala Asn Ser Glu Thr Ser
        675                 680                 685             
Asp Leu Ser Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Ile
    690                 695                 700                 
Phe Leu Val Phe Val Ile Val Leu Leu Ala Leu Arg Leu Trp Arg Trp
705                 710                 715                 720 
His Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Gly Met
                725                 730                 735     
Pro Thr Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln
            740                 745                 750         
Thr Tyr Ser His Glu Val Ser Leu Ile Ala Asp Ser Gln Lys Ser His
        755                 760                 765             
Leu Ile Phe Pro Gln Pro Asn Tyr Gly Asp Thr Leu Ile Ser Gln Glu
    770                 775                 780                 
Ser Cys Glu Lys Ser Glu Pro Leu Leu Ile Ala Glu Asp Ser Ala Ile
785                 790                 795                 800 
Ile Leu Gly Lys Cys Asp Pro Thr Ser Asn Gln Gln Ala Pro Pro Asn
                805                 810                 815     
Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser
            820                 825                 830         
Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr
        835                 840                 845             
Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp
    850                 855                 860                 
Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala
865                 870                 875                 880 
Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln
                885                 890                 895     
Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly
            900                 905                 910         
Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys
        915                 920                 925             
Ser Gly Lys Lys Glu Lys Lys
    930                 935 


<210> 6429
<211> 923
<212> PRT
<213> Homo sapiens

<400> 6429
Met Gly Ser Gly Ala Gly Glu Leu Gly Arg Ala Glu Arg Leu Pro Val
 1               5                  10                  15      
Leu Phe Leu Phe Leu Leu Ser Leu Phe Cys Pro Ala Leu Cys Glu Gln
            20                  25                  30          
Ile Arg Tyr Arg Ile Pro Glu Glu Met Pro Lys Gly Ser Val Val Gly
        35                  40                  45              
Asn Leu Ala Thr Asp Leu Gly Phe Ser Val Gln Glu Leu Pro Thr Arg
    50                  55                  60                  
Lys Leu Arg Val Ser Ser Glu Lys Pro Tyr Phe Thr Val Ser Ala Glu
65                  70                  75                  80  
Ser Gly Glu Leu Leu Val Ser Ser Arg Leu Asp Arg Glu Glu Ile Cys
                85                  90                  95      
Gly Lys Lys Pro Ala Cys Ala Leu Glu Phe Glu Ala Val Ala Glu Asn
            100                 105                 110         
Pro Leu Asn Phe Tyr His Val Asn Val Glu Ile Glu Asp Ile Asn Asp
        115                 120                 125             
His Thr Pro Lys Phe Thr Gln Asn Ser Phe Glu Leu Gln Ile Ser Glu
    130                 135                 140                 
Ser Ala Gln Pro Gly Thr Arg Phe Ile Leu Gly Ser Ala His Asp Ala
145                 150                 155                 160 
Asp Ile Gly Ser Asn Thr Leu Gln Asn Tyr Gln Leu Ser Pro Ser Asp
                165                 170                 175     
His Phe Ser Leu Ile Asn Lys Glu Lys Ser Asp Gly Ser Lys Tyr Pro
            180                 185                 190         
Glu Met Val Leu Lys Thr Pro Leu Asp Arg Glu Lys Gln Lys Ser Tyr
        195                 200                 205             
His Leu Thr Leu Thr Ala Leu Asp Phe Gly Ala Pro Pro Leu Ser Ser
    210                 215                 220                 
Thr Ala Gln Ile His Val Leu Val Thr Asp Ala Asn Asp Asn Ala Pro
225                 230                 235                 240 
Val Phe Ser Gln Asp Val Tyr Arg Val Ser Leu Ser Glu Asn Val Tyr
                245                 250                 255     
Pro Gly Thr Thr Val Leu Gln Val Thr Ala Thr Asp Gln Asp Glu Gly
            260                 265                 270         
Val Asn Ala Glu Ile Thr Phe Ser Phe Ser Glu Ala Ser Gln Ile Thr
        275                 280                 285             
Gln Phe Asp Leu Asn Ser Asn Thr Gly Glu Ile Thr Val Leu Asn Thr
    290                 295                 300                 
Leu Asp Phe Glu Glu Val Lys Glu Tyr Ser Ile Val Leu Glu Ala Arg
305                 310                 315                 320 
Asp Gly Gly Gly Met Ile Ala Gln Cys Thr Val Glu Val Glu Val Ile
                325                 330                 335     
Asp Glu Asn Asp Asn Ala Pro Glu Val Ile Phe Gln Ser Leu Pro Asn
            340                 345                 350         
Leu Ile Met Glu Asp Ala Glu Leu Gly Thr His Ile Ala Leu Leu Lys
        355                 360                 365             
Val Arg Asp Lys Asp Ser Arg His Asn Gly Glu Val Thr Cys Lys Leu
    370                 375                 380                 
Glu Gly Asp Val Pro Phe Lys Ile Leu Thr Ser Ser Arg Asn Thr Tyr
385                 390                 395                 400 
Lys Leu Val Thr Asp Ala Val Leu Asp Arg Glu Gln Asn Pro Glu Tyr
                405                 410                 415     
Asn Ile Thr Val Thr Ala Thr Asp Arg Gly Lys Pro Pro Leu Ser Ser
            420                 425                 430         
Ser Ser Ser Ile Thr Leu His Ile Gly Asp Val Asn Asp Asn Ala Pro
        435                 440                 445             
Val Phe Ser Gln Ser Ser Tyr Ile Val His Val Ala Glu Asn Asn Pro
    450                 455                 460                 
Pro Gly Ala Ser Ile Ser Gln Val Arg Ala Ser Asp Pro Asp Leu Gly
465                 470                 475                 480 
Pro Asn Gly Gln Val Ser Tyr Cys Ile Met Ala Ser Asp Leu Glu Gln
                485                 490                 495     
Arg Glu Leu Ser Ser Tyr Val Ser Ile Ser Ala Glu Ser Gly Val Val
            500                 505                 510         
Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe Glu Leu
        515                 520                 525             
Thr Leu Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala Asn Val
    530                 535                 540                 
Ser Leu Arg Val Leu Val Asp Asp Arg Asn Asp Asn Ala Pro Arg Val
545                 550                 555                 560 
Leu Tyr Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp Met Val
                565                 570                 575     
Pro His Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val
            580                 585                 590         
Asp Ala Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val Leu Gln
        595                 600                 605             
Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly Glu Val
    610                 615                 620                 
Arg Thr Ala Arg Ala Leu Gly Asp Arg Asp Ala Val Arg Gln Arg Leu
625                 630                 635                 640 
Leu Val Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala Thr Ala
                645                 650                 655     
Thr Leu His Leu Val Phe Ala Asp Ser Leu Gln Glu Val Leu Pro Asp
            660                 665                 670         
Ile Thr Asp Arg Pro Asp Pro Ser Asp Leu Gln Ala Glu Leu Gln Phe
        675                 680                 685             
Tyr Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu Val Ala
    690                 695                 700                 
Met Ile Leu Ala Ile Ala Leu Arg Leu Arg Arg Ser Ser Ser Pro Ala
705                 710                 715                 720 
Ser Trp Ser Cys Phe Gln Pro Gly Leu Cys Val Lys Ser Glu Ser Val
                725                 730                 735     
Val Pro Pro Asn Tyr Ser Glu Gly Thr Leu Pro Tyr Ser Tyr Asn Leu
            740                 745                 750         
Cys Val Ala His Thr Gly Lys Thr Glu Phe Asn Phe Leu Lys Cys Ser
        755                 760                 765             
Glu Gln Leu Ser Ser Gly Gln Asp Ile Leu Cys Gly Asp Ser Ser Gly
    770                 775                 780                 
Ala Leu Phe Pro Leu Cys Asn Ser Ser Glu Leu Thr Ser His Gln Gln
785                 790                 795                 800 
Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly
                805                 810                 815     
Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn
            820                 825                 830         
Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser
        835                 840                 845             
Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met
    850                 855                 860                 
Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro
865                 870                 875                 880 
Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr
                885                 890                 895     
Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly
            900                 905                 910         
Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys
        915                 920             


<210> 6430
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6430
Met Ala Ala Gln Pro Arg Gly Gly Asp Tyr Arg Gly Phe Phe Leu Leu
 1               5                  10                  15      
Ser Ile Leu Leu Gly Thr Pro Trp Glu Ala Trp Ala Gly Arg Ile Leu
            20                  25                  30          
Tyr Ser Val Ser Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asp Ile
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Glu Arg Gly Val
    50                  55                  60                  
Arg Ile Ile Ser Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Gln Arg
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Ile Cys
                85                  90                  95      
Ala Gln Ser Ala Arg Cys Leu Val Asn Phe Asn Ile Leu Met Glu Asp
            100                 105                 110         
Lys Met Asn Leu Tyr Pro Ile Asp Val Glu Ile Ile Asp Ile Asn Asp
        115                 120                 125             
Asn Val Pro Arg Phe Leu Thr Glu Glu Ile Asn Val Lys Ile Met Glu
    130                 135                 140                 
Asn Thr Ala Pro Gly Val Arg Phe Pro Leu Ser Glu Ala Gly Asp Pro
145                 150                 155                 160 
Asp Val Gly Thr Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn Arg
                165                 170                 175     
His Phe Ser Leu Ala Val Gln Ser Gly Asp Asp Glu Thr Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Val Leu Asp Arg Glu Glu Glu Arg Val His
        195                 200                 205             
His Leu Val Leu Thr Ala Ser Asp Gly Gly Asp Pro Pro Arg Ser Ser
    210                 215                 220                 
Thr Ala His Ile Gln Val Thr Val Val Asp Val Asn Asp His Thr Pro
225                 230                 235                 240 
Val Phe Ser Leu Pro Gln Tyr Gln Val Thr Val Pro Glu Asn Val Pro
                245                 250                 255     
Val Gly Thr Arg Leu Leu Thr Val His Ala Ile Asp Leu Asp Glu Gly
            260                 265                 270         
Val Asn Gly Glu Val Thr Tyr Ser Phe Arg Lys Ile Thr Pro Lys Leu
        275                 280                 285             
Pro Lys Met Phe His Leu Asn Ser Leu Thr Gly Glu Ile Ser Thr Leu
    290                 295                 300                 
Glu Gly Leu Asp Tyr Glu Glu Thr Ala Phe Tyr Glu Met Glu Val Gln
305                 310                 315                 320 
Ala Gln Asp Gly Pro Gly Ser Leu Thr Lys Ala Lys Val Leu Ile Thr
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Met Thr Ser Leu
            340                 345                 350         
Ser Ser Ser Ile Pro Glu Asp Thr Pro Leu Gly Thr Val Ile Ala Leu
        355                 360                 365             
Phe Tyr Leu Gln Asp Arg Asp Ser Gly Lys Asn Gly Glu Val Thr Cys
    370                 375                 380                 
Thr Ile Pro Glu Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Asp Asn
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Thr Lys Asn Leu Asp Arg Glu Thr Leu Ser
                405                 410                 415     
Leu Tyr Asn Ile Thr Leu Lys Ala Thr Asp Gly Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Arg Glu Thr His Ile Phe Met Gln Val Ala Asp Thr Asn Asp Asn
        435                 440                 445             
Pro Pro Thr Phe Pro His Ser Ser Tyr Ser Val Tyr Ile Ala Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Ile Phe Leu Val Thr Ala Gln Asp His Asp
465                 470                 475                 480 
Ser Glu Asp Asn Ala Gln Ile Thr Tyr Ser Leu Ala Glu Asp Thr Ile
                485                 490                 495     
Gln Gly Ala Pro Val Ser Ser Tyr Val Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Leu Arg Glu Leu
        515                 520                 525             
Gln Leu Arg Val Thr Ala His Asp Ser Gly Asp Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Met Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Pro Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Met Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Leu Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Leu Tyr Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Pro Ser Asp Gly Pro Tyr Asn Tyr Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Thr Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Leu Val Leu Leu Ala Leu Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Asn Val Pro
                725                 730                 735     
Thr Ser His Phe Val Gly Met Asp Gly Val Gln Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Val Asp Met Leu Ile Ser Gln Glu Ser
    770                 775                 780                 
Cys Glu Lys Asn Asp Ser Leu Leu Thr Ser Val Asp Phe Gln Glu Cys
785                 790                 795                 800 
Lys Glu Asn Leu Pro Ser Ile Gln Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 6431
<211> 931
<212> PRT
<213> Homo sapiens

<400> 6431
Met Lys Ile Gln Lys Lys Leu Thr Gly Cys Ser Arg Leu Met Leu Leu
 1               5                  10                  15      
Cys Leu Ser Leu Glu Leu Leu Leu Glu Ala Gly Ala Gly Asn Ile His
            20                  25                  30          
Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Gln Pro Gln Glu Leu Ala Asp Gly Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Met Pro Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Ser Leu Ile Thr Ala Arg Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ser Met Pro Cys Leu Val Ser Phe Asn Ile Leu Val Glu Asp
            100                 105                 110         
Lys Met Lys Leu Phe Pro Val Glu Val Glu Ile Ile Asp Ile Asn Asp
        115                 120                 125             
Asn Thr Pro Gln Phe Gln Leu Glu Glu Leu Glu Phe Lys Met Asn Glu
    130                 135                 140                 
Ile Thr Thr Pro Gly Thr Arg Val Ser Leu Pro Phe Gly Gln Asp Leu
145                 150                 155                 160 
Asp Val Gly Met Asn Ser Leu Gln Ser Tyr Gln Leu Ser Ser Asn Pro
                165                 170                 175     
His Phe Ser Leu Asp Val Gln Gln Gly Ala Asp Gly Pro Gln His Pro
            180                 185                 190         
Glu Met Val Leu Gln Ser Pro Leu Asp Arg Glu Glu Glu Ala Val His
        195                 200                 205             
His Leu Ile Leu Thr Ala Ser Asp Gly Gly Glu Pro Val Arg Ser Gly
    210                 215                 220                 
Thr Leu Arg Ile Tyr Ile Gln Val Val Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Ala Phe Thr Gln Ala Gln Tyr His Ile Asn Val Pro Glu Asn Val Pro
                245                 250                 255     
Leu Gly Thr Gln Leu Leu Met Val Asn Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Ala Asn Gly Glu Val Thr Tyr Ser Phe His Asn Val Asp His Arg Val
        275                 280                 285             
Ala Gln Ile Phe Arg Leu Asp Ser Tyr Thr Gly Glu Ile Ser Asn Lys
    290                 295                 300                 
Glu Pro Leu Asp Phe Glu Glu Tyr Lys Met Tyr Ser Met Glu Val Gln
305                 310                 315                 320 
Ala Gln Asp Gly Ala Gly Leu Met Ala Lys Val Lys Val Leu Ile Lys
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile Thr Ser Val
            340                 345                 350         
Thr Thr Ala Val Pro Glu Asn Phe Pro Pro Gly Thr Ile Ile Ala Leu
        355                 360                 365             
Ile Ser Val His Asp Gln Asp Ser Gly Asp Asn Gly Tyr Thr Thr Cys
    370                 375                 380                 
Phe Ile Pro Gly Asn Leu Pro Phe Lys Leu Glu Lys Leu Val Asp Asn
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Glu Arg Thr Leu Asp Arg Glu Leu Ile Ser
                405                 410                 415     
Gly Tyr Asn Ile Thr Ile Thr Ala Ile Asp Gln Gly Thr Pro Ala Leu
            420                 425                 430         
Ser Thr Glu Thr His Ile Ser Leu Leu Val Thr Asp Ile Asn Asp Asn
        435                 440                 445             
Ser Pro Val Phe His Gln Asp Ser Tyr Ser Ala Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Arg Ala His Asp Leu Asp
465                 470                 475                 480 
Ser Asn Glu Asn Ala Gln Ile Thr Tyr Ser Leu Ile Glu Asp Thr Ile
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ala Tyr Leu Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Phe Arg Asp Met
        515                 520                 525             
Gln Leu Lys Val Met Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Leu Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Leu Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Ser Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Ala Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Met Pro
                725                 730                 735     
Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser
    770                 775                 780                 
Cys Glu Lys Lys Gly Phe Leu Ser Ala Pro Gln Ser Leu Leu Glu Asp
785                 790                 795                 800 
Lys Lys Glu Pro Phe Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg
                805                 810                 815     
Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp
            820                 825                 830         
Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln
        835                 840                 845             
Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr
    850                 855                 860                 
Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro
865                 870                 875                 880 
Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile
                885                 890                 895     
Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly
            900                 905                 910         
Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys
        915                 920                 925             
Glu Lys Lys
    930     


<210> 6432
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6432
Met Thr Asn Cys Leu Ser Phe Arg Asn Gly Arg Gly Leu Ala Leu Leu
 1               5                  10                  15      
Cys Ala Leu Leu Gly Thr Leu Cys Glu Thr Gly Ser Ser Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Ser Glu Glu Leu Asp Lys Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Ala Asn Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Glu Arg Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser Leu Asn Pro Gln
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Glu Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ile Pro Leu Cys Leu Val Lys Ile Asn Ile Leu Val Glu Asp
            100                 105                 110         
Lys Leu Lys Ile Phe Glu Val Glu Ile Glu Ile Lys Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Asn Phe Pro Thr Glu Glu Leu Glu Ile Lys Ile Gly Glu
    130                 135                 140                 
Leu Thr Val Pro Gly Thr Arg Phe Pro Ile Lys Thr Ala Phe Asp Pro
145                 150                 155                 160 
Asp Val Gly Ile Asn Ser Leu Gln Asn Tyr Lys Leu Ser Pro Asn Asp
                165                 170                 175     
Tyr Phe Ser Leu Ala Val Asn Ser Val Ser Glu Gly Ala Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Lys Lys Glu Ile His
        195                 200                 205             
Gln Leu Val Leu Val Ala Ser Asp Gly Gly Asp Pro Val His Ser Gly
    210                 215                 220                 
Asn Leu His Ile Gln Val Ile Val Leu Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Met Phe Thr Gln Pro Glu Tyr Arg Val Ser Val Trp Glu Asn Val Pro
                245                 250                 255     
Val Gly Thr Arg Leu Leu Thr Val Asn Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Phe Asn Ala Gln Val Ser Tyr Ile Leu Asp Lys Met Pro Gly Lys Ile
        275                 280                 285             
Ala Glu Ile Phe His Leu Asn Ser Val Ser Gly Glu Val Ser Ile Leu
    290                 295                 300                 
Lys Ser Leu Asp Tyr Glu Asp Ala Met Phe Tyr Glu Ile Lys Ile Glu
305                 310                 315                 320 
Ala Gln Asp Gly Pro Gly Leu Leu Ser Arg Ala Lys Ile Leu Val Thr
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser Leu
            340                 345                 350         
Thr Ser Ser Val Pro Glu Glu Gly Thr Val Gly Arg Glu Ile Ala Leu
        355                 360                 365             
Ile Asp Val His Asp Arg Asp Ser Gly Gln Asn Gly Gln Val Glu Val
    370                 375                 380                 
Phe Val Leu Gly Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Asp Gln
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Ala Thr Ser Leu Asp Arg Glu Gln Ile Ser
                405                 410                 415     
Glu Tyr Asn Ile Ser Leu Arg Ala Ser Asp Gly Gly Ser Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Thr His Ile Thr Leu His Val Ile Asp Ile Asn Asp Asn
        435                 440                 445             
Pro Pro Thr Phe Pro His Leu Ser Tyr Ser Ala Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Gln Asp Pro Asp
465                 470                 475                 480 
Ser Asn Asn Asn Ala Arg Ile Thr Tyr Ala Leu Thr Glu Asp Thr Leu
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Phe Val Ser Ile Asn Ser Asn Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu
        515                 520                 525             
Lys Leu Leu Val Thr Ala Ser Asp Ser Gly Asn Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Asn Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Ile Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Ile Val Ala Val Ala Asp Arg Ile Pro Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Val Leu Leu Ala Leu Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Thr Pro
                725                 730                 735     
Gly Ser His Phe Val Gly Ala Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser
    770                 775                 780                 
Cys Glu Lys Ser Glu Pro Leu Leu Ile Thr Gln Asp Leu Leu Glu Met
785                 790                 795                 800 
Lys Gly Asp Ser Asn Leu Leu Gln Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 6433
<211> 923
<212> PRT
<213> Homo sapiens

<400> 6433
Met Gly Ser Gly Ala Gly Glu Leu Gly Arg Ala Glu Arg Leu Pro Val
 1               5                  10                  15      
Leu Phe Leu Phe Leu Leu Ser Leu Phe Cys Pro Ala Leu Cys Glu Gln
            20                  25                  30          
Ile Arg Tyr Arg Ile Pro Glu Glu Met Pro Lys Gly Ser Val Val Gly
        35                  40                  45              
Asn Leu Ala Thr Asp Leu Gly Phe Ser Val Gln Glu Leu Pro Thr Arg
    50                  55                  60                  
Lys Leu Arg Val Ser Ser Glu Lys Pro Tyr Phe Thr Val Ser Ala Glu
65                  70                  75                  80  
Ser Gly Glu Leu Leu Val Ser Ser Arg Leu Asp Arg Glu Glu Ile Cys
                85                  90                  95      
Gly Lys Lys Pro Ala Cys Ala Leu Glu Phe Glu Ala Val Ala Glu Asn
            100                 105                 110         
Pro Leu Asn Phe Tyr His Val Asn Val Glu Ile Glu Asp Ile Asn Asp
        115                 120                 125             
His Thr Pro Lys Phe Thr Gln Asn Ser Phe Glu Leu Gln Ile Ser Glu
    130                 135                 140                 
Ser Ala Gln Pro Gly Thr Arg Phe Ile Leu Glu Val Ala Glu Asp Ala
145                 150                 155                 160 
Asp Ile Gly Leu Asn Ser Leu Gln Lys Tyr Lys Leu Ser Leu Asn Pro
                165                 170                 175     
Ser Phe Ser Leu Ile Ile Lys Glu Lys Gln Asp Gly Ser Lys Tyr Pro
            180                 185                 190         
Glu Leu Ala Leu Glu Lys Thr Leu Asp Arg Glu Gln Gln Ser Tyr His
        195                 200                 205             
Arg Leu Val Leu Thr Ala Leu Asp Gly Gly His Pro Pro Leu Ser Gly
    210                 215                 220                 
Thr Thr Glu Leu Arg Ile Gln Val Thr Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Val Phe Asn Arg Asp Val Tyr Arg Val Ser Leu Arg Glu Asn Val Pro
                245                 250                 255     
Pro Gly Thr Thr Val Leu Gln Val Ser Ala Thr Asp Gln Asp Glu Gly
            260                 265                 270         
Ile Asn Ser Glu Ile Thr Tyr Ser Phe Tyr Arg Thr Gly Gln Ile Phe
        275                 280                 285             
Ser Leu Asn Ser Lys Ser Gly Glu Ile Thr Thr Gln Lys Lys Leu Asp
    290                 295                 300                 
Phe Glu Glu Thr Lys Glu Tyr Ser Met Val Val Glu Gly Arg Asp Gly
305                 310                 315                 320 
Gly Gly Leu Val Ala Gln Cys Thr Val Glu Ile Asn Ile Gln Asp Glu
                325                 330                 335     
Asn Asp Asn Ser Pro Glu Val Thr Phe His Ser Leu Leu Glu Met Ile
            340                 345                 350         
Leu Glu Asn Ala Val Pro Gly Thr Leu Ile Ala Leu Ile Lys Ile His
        355                 360                 365             
Asp Gln Asp Ser Gly Glu Asn Gly Glu Val Asn Cys Gln Leu Gln Gly
    370                 375                 380                 
Glu Val Pro Phe Lys Ile Ile Ser Ser Ser Lys Asn Ser Tyr Lys Leu
385                 390                 395                 400 
Val Thr Asp Gly Thr Leu Asp Arg Glu Gln Thr Pro Glu Tyr Asn Val
                405                 410                 415     
Thr Ile Thr Ala Thr Asp Arg Gly Lys Pro Pro Leu Ser Ser Ser Ile
            420                 425                 430         
Ser Val Ile Leu His Ile Arg Asp Val Asn Asp Asn Ala Pro Val Phe
        435                 440                 445             
His Gln Ala Ser Tyr Leu Val Ser Val Pro Glu Asn Asn Pro Pro Gly
    450                 455                 460                 
Ala Ser Ile Ala Gln Val Cys Ala Ser Asp Leu Asp Leu Gly Leu Asn
465                 470                 475                 480 
Gly Gln Val Ser Tyr Ser Ile Met Ala Ser Asp Leu Glu Pro Leu Ala
                485                 490                 495     
Leu Ala Ser Tyr Val Ser Met Ser Ala Gln Ser Gly Val Val Phe Ala
            500                 505                 510         
Gln Arg Ala Phe Asp Tyr Glu Gln Leu Arg Thr Phe Glu Leu Thr Leu
        515                 520                 525             
Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala Asn Val Ser Leu
    530                 535                 540                 
Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro Arg Val Leu Tyr
545                 550                 555                 560 
Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp Met Val Pro Arg
                565                 570                 575     
Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Ala
            580                 585                 590         
Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val Leu Gln Ala Ser
        595                 600                 605             
Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly Glu Val Arg Thr
    610                 615                 620                 
Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln Arg Leu Leu Val
625                 630                 635                 640 
Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala Thr Ala Thr Leu
                645                 650                 655     
His Leu Val Phe Ala Asp Ser Leu Gln Glu Val Leu Pro Asp Ile Thr
            660                 665                 670         
Asp Arg Pro Val Pro Ser Asp Pro Gln Ala Glu Leu Gln Phe Tyr Leu
        675                 680                 685             
Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu Leu Ala Val Ile
    690                 695                 700                 
Leu Ala Val Ala Leu Arg Leu Arg Arg Ser Ser Ser Pro Ala Ala Trp
705                 710                 715                 720 
Ser Cys Phe Gln Pro Gly Leu Cys Val Lys Ser Gly Pro Val Val Pro
                725                 730                 735     
Pro Asn Tyr Ser Gln Gly Thr Leu Pro Tyr Ser Tyr Asn Leu Cys Val
            740                 745                 750         
Ala His Thr Gly Lys Thr Glu Phe Asn Phe Leu Lys Cys Ser Glu Gln
        755                 760                 765             
Leu Ser Ser Gly Gln Asp Ile Leu Cys Gly Asp Ser Ser Gly Ala Leu
    770                 775                 780                 
Phe Pro Leu Cys Asn Ser Ser Glu Ser Thr Ser His Pro Glu Leu Gln
785                 790                 795                 800 
Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly
                805                 810                 815     
Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn
            820                 825                 830         
Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser
        835                 840                 845             
Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met
    850                 855                 860                 
Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro
865                 870                 875                 880 
Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr
                885                 890                 895     
Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly
            900                 905                 910         
Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys
        915                 920             


<210> 6434
<211> 936
<212> PRT
<213> Homo sapiens

<400> 6434
Met Ala Ala Gln Arg Asn Arg Ser Lys Glu Ser Lys Asp Cys Ser Gly
 1               5                  10                  15      
Leu Val Leu Leu Cys Leu Phe Phe Gly Ile Pro Trp Glu Ala Gly Ala
            20                  25                  30          
Arg Gln Ile Ser Tyr Ser Ile Pro Glu Glu Leu Glu Lys Gly Ser Phe
        35                  40                  45              
Val Gly Asn Ile Ser Lys Asp Leu Gly Leu Ala Pro Arg Glu Leu Ala
    50                  55                  60                  
Glu Arg Gly Val Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser
65                  70                  75                  80  
Leu Asn Pro Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg
                85                  90                  95      
Glu Glu Leu Cys Ala Gln Ser Ala Arg Cys Val Val Ser Phe Asn Ile
            100                 105                 110         
Leu Val Glu Asp Arg Val Lys Leu Phe Gly Ile Glu Ile Glu Val Thr
        115                 120                 125             
Asp Ile Asn Asp Asn Ala Pro Lys Phe Gln Ala Glu Asn Leu Asp Val
    130                 135                 140                 
Lys Ile Asn Glu Asn Val Ala Ala Gly Met Arg Phe Pro Leu Pro Glu
145                 150                 155                 160 
Ala Ile Asp Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu
                165                 170                 175     
Ser Pro Asn Lys His Phe Ser Leu Arg Val Gln Ser Arg Ala Asn Gly
            180                 185                 190         
Val Lys Tyr Pro Glu Leu Val Leu Glu His Ser Leu Asp Arg Glu Glu
        195                 200                 205             
Glu Ala Ile His His Leu Val Leu Thr Ala Ser Asp Gly Gly Asp Pro
    210                 215                 220                 
Leu Arg Ser Gly Thr Val Leu Val Ser Val Thr Val Phe Asp Ala Asn
225                 230                 235                 240 
Asp Asn Ala Pro Val Phe Thr Leu Pro Glu Tyr Arg Val Ser Val Pro
                245                 250                 255     
Glu Asn Leu Pro Val Gly Thr Gln Leu Leu Thr Val Thr Ala Thr Asp
            260                 265                 270         
Arg Asp Glu Gly Ala Asn Gly Glu Val Thr Tyr Ser Phe Arg Lys Leu
        275                 280                 285             
Pro Asp Thr Gln Leu Leu Lys Phe Gln Leu Asn Lys Tyr Thr Gly Glu
    290                 295                 300                 
Ile Lys Ile Ser Glu Asn Leu Asp Tyr Glu Glu Thr Gly Phe Tyr Glu
305                 310                 315                 320 
Ile Glu Ile Gln Ala Glu Asp Gly Gly Ala Tyr Leu Ala Thr Ala Lys
                325                 330                 335     
Val Leu Ile Thr Val Glu Asp Val Asn Asp Asn Ser Pro Glu Leu Thr
            340                 345                 350         
Ile Thr Ser Leu Phe Ser Pro Val Thr Glu Asp Ser Pro Leu Gly Thr
        355                 360                 365             
Val Val Ala Leu Leu Asn Val His Asp Leu Asp Ser Glu Gln Asn Gly
    370                 375                 380                 
Gln Val Thr Cys Ser Ile Leu Ala Tyr Leu Pro Phe Lys Leu Glu Lys
385                 390                 395                 400 
Ser Ile Asp Ser Tyr Tyr Arg Leu Val Ile His Arg Ala Leu Asp Arg
                405                 410                 415     
Glu Gln Val Ser Ser Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly
            420                 425                 430         
Ser Pro Pro Leu Ser Thr Glu Ala His Phe Met Leu Gln Val Ala Asp
        435                 440                 445             
Ile Asn Asp Asn Pro Pro Thr Phe Ser Gln Val Ser Tyr Phe Thr Tyr
    450                 455                 460                 
Ile Pro Glu Asn Asn Ala Arg Gly Ala Ser Ile Phe Ser Val Thr Ala
465                 470                 475                 480 
Leu Asp Pro Asp Ser Lys Glu Asn Ala Gln Ile Ile Tyr Ser Leu Ala
                485                 490                 495     
Glu Asp Thr Ile Gln Gly Val Pro Leu Ser Ser Tyr Ile Ser Ile Asn
            500                 505                 510         
Ser Asp Thr Gly Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln
        515                 520                 525             
Phe His Glu Leu Gln Met Gln Val Thr Ala Ser Asp Ser Gly Asp Pro
    530                 535                 540                 
Pro Leu Ser Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn
545                 550                 555                 560 
Asp Asn Ala Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser
                565                 570                 575     
Thr Gly Val Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val
            580                 585                 590         
Thr Lys Val Val Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu
        595                 600                 605             
Ser Tyr Arg Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly
    610                 615                 620                 
Glu His Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp
625                 630                 635                 640 
Ala Leu Lys Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro
                645                 650                 655     
Pro Leu Ser Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile
            660                 665                 670         
Pro Gln Val Leu Ala Asp Leu Gly Ser Phe Glu Ser Pro Ala Asn Ser
        675                 680                 685             
Glu Thr Ser Asp Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val
    690                 695                 700                 
Ser Cys Val Phe Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu
705                 710                 715                 720 
Arg Arg Trp His Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu
                725                 730                 735     
Thr Gly Val Ser Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala
            740                 745                 750         
Phe Leu Gln Thr Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg
        755                 760                 765             
Lys Ser His Leu Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile
    770                 775                 780                 
Ser Gln Glu Ser Cys Glu Lys Asn Asp Pro Leu Ser Leu Leu Asp Asp
785                 790                 795                 800 
Ser Lys Phe Pro Ile Glu Asp Thr Pro Leu Val Pro Gln Ala Pro Pro
                805                 810                 815     
Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly
            820                 825                 830         
Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp
        835                 840                 845             
Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala
    850                 855                 860                 
Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser
865                 870                 875                 880 
Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg
                885                 890                 895     
Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala
            900                 905                 910         
Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys
        915                 920                 925             
Lys Ser Gly Lys Lys Glu Lys Lys
    930                 935     


<210> 6435
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6435
Met Ile Pro Ala Arg Leu His Arg Asp Tyr Lys Gly Leu Val Leu Leu
 1               5                  10                  15      
Gly Ile Leu Leu Gly Thr Leu Trp Glu Thr Gly Cys Thr Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Pro Glu Glu Leu Glu Lys Gly Ser Arg Val Gly Asp Ile
        35                  40                  45              
Ser Arg Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Glu Arg Gly Val
    50                  55                  60                  
Arg Ile Ile Pro Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Met Gly Ala Ile Lys Cys Gln Leu Asn Leu Asp Ile Leu Met Glu Asp
            100                 105                 110         
Lys Val Lys Ile Tyr Gly Val Glu Val Glu Val Arg Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Tyr Phe Arg Glu Ser Glu Leu Glu Ile Lys Ile Ser Glu
    130                 135                 140                 
Asn Ala Ala Thr Glu Met Arg Phe Pro Leu Pro His Ala Trp Asp Pro
145                 150                 155                 160 
Asp Ile Gly Lys Asn Ser Leu Gln Ser Tyr Glu Leu Ser Pro Asn Thr
                165                 170                 175     
His Phe Ser Leu Ile Val Gln Asn Gly Ala Asp Gly Ser Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Lys Arg Ala Leu Asp Arg Glu Glu Lys Ala Ala His
        195                 200                 205             
His Leu Val Leu Thr Ala Ser Asp Gly Gly Asp Pro Val Arg Thr Gly
    210                 215                 220                 
Thr Ala Arg Ile Arg Val Met Val Leu Asp Ala Asn Asp Asn Ala Pro
225                 230                 235                 240 
Ala Phe Ala Gln Pro Glu Tyr Arg Ala Ser Val Pro Glu Asn Leu Ala
                245                 250                 255     
Leu Gly Thr Gln Leu Leu Val Val Asn Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Val Asn Ala Glu Val Arg Tyr Ser Phe Arg Tyr Val Asp Asp Lys Ala
        275                 280                 285             
Ala Gln Val Phe Lys Leu Asp Cys Asn Ser Gly Thr Ile Ser Thr Ile
    290                 295                 300                 
Gly Glu Leu Asp His Glu Glu Ser Gly Phe Tyr Gln Met Glu Val Gln
305                 310                 315                 320 
Ala Met Asp Asn Ala Gly Tyr Ser Ala Arg Ala Lys Val Leu Ile Thr
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr Ser Leu
            340                 345                 350         
Ala Ser Ser Val Pro Glu Asn Ser Pro Arg Gly Thr Leu Ile Ala Leu
        355                 360                 365             
Leu Asn Val Asn Asp Gln Asp Ser Glu Glu Asn Gly Gln Val Ile Cys
    370                 375                 380                 
Phe Ile Gln Gly Asn Leu Pro Phe Lys Leu Glu Lys Ser Tyr Gly Asn
385                 390                 395                 400 
Tyr Tyr Ser Leu Val Thr Asp Ile Val Leu Asp Arg Glu Gln Val Pro
                405                 410                 415     
Ser Tyr Asn Ile Thr Val Thr Ala Thr Asp Arg Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Thr His Ile Ser Leu Asn Val Ala Asp Thr Asn Asp Asn
        435                 440                 445             
Pro Pro Val Phe Pro Gln Ala Ser Tyr Ser Ala Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Val Ser Leu Val Ser Val Thr Ala His Asp Pro Asp
465                 470                 475                 480 
Cys Glu Glu Asn Ala Gln Ile Thr Tyr Ser Leu Ala Glu Asn Thr Ile
                485                 490                 495     
Gln Gly Ala Ser Leu Ser Ser Tyr Val Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Ser Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu
        515                 520                 525             
Gln Val Lys Val Met Ala Arg Asp Asn Gly His Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Gln Val Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Ser Pro Ala Asn Ser Glu Thr Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Leu Leu Leu Ala Leu Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Thr Gly Ala Pro
                725                 730                 735     
Ala Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Thr Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Met Leu Val Ser Gln Glu Ser
    770                 775                 780                 
Phe Glu Lys Ser Glu Pro Leu Leu Leu Ser Gly Asp Ser Val Phe Ser
785                 790                 795                 800 
Lys Asp Ser His Gly Leu Ile Glu Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 6436
<211> 930
<212> PRT
<213> Homo sapiens

<400> 6436
Met Gly Gly Ser Cys Ala Gln Arg Arg Arg Ala Gly Pro Arg Gln Val
 1               5                  10                  15      
Leu Phe Pro Leu Leu Leu Pro Leu Phe Tyr Pro Thr Leu Ser Glu Pro
            20                  25                  30          
Ile Arg Tyr Ser Ile Pro Glu Glu Leu Ala Lys Gly Ser Val Val Gly
        35                  40                  45              
Asn Leu Ala Lys Asp Leu Gly Leu Ser Val Leu Asp Val Ser Ala Arg
    50                  55                  60                  
Lys Leu Arg Val Ser Ala Glu Lys Leu His Phe Ser Val Asp Ala Glu
65                  70                  75                  80  
Ser Gly Asp Leu Leu Val Lys Asn Arg Ile Asp Arg Glu Gln Ile Cys
                85                  90                  95      
Lys Glu Arg Arg Arg Cys Glu Leu Gln Leu Glu Ala Val Val Glu Asn
            100                 105                 110         
Pro Leu Asn Ile Phe His Val Ile Val Val Ile Glu Asp Val Asn Asp
        115                 120                 125             
His Ala Pro Gln Phe Asp Lys Lys Glu Ile His Leu Glu Ile Phe Glu
    130                 135                 140                 
Ser Ala Ser Ala Gly Thr Arg Leu Ser Leu Asp Pro Ala Thr Asp Pro
145                 150                 155                 160 
Asp Ile Asn Ile Asn Ser Ile Lys Asp Tyr Lys Ile Asn Ser Asn Pro
                165                 170                 175     
Tyr Phe Ser Leu Met Val Arg Val Asn Ser Asp Gly Gly Lys Tyr Pro
            180                 185                 190         
Glu Leu Ser Leu Glu Lys Leu Leu Asp Arg Glu Glu Gln Arg Ser His
        195                 200                 205             
Ser Leu Ile Leu Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Ser Ala
    210                 215                 220                 
Thr Ala His Ile Glu Ile Ser Val Lys Asp Thr Asn Asp Asn Pro Pro
225                 230                 235                 240 
Val Phe Ser Arg Asp Glu Tyr Arg Ile Ser Leu Ser Glu Asn Leu Pro
                245                 250                 255     
Pro Gly Ser Pro Val Leu Gln Val Thr Ala Thr Asp Gln Asp Glu Gly
            260                 265                 270         
Val Asn Ala Glu Ile Asn Tyr Tyr Phe Arg Ser Thr Ala Gln Ser Thr
        275                 280                 285             
Lys His Met Phe Ser Leu Asp Glu Lys Thr Gly Met Ile Lys Asn Asn
    290                 295                 300                 
Gln Ser Phe Asp Phe Glu Asp Val Glu Arg Tyr Thr Met Glu Val Glu
305                 310                 315                 320 
Ala Lys Asp Gly Gly Gly Leu Ser Thr Gln Cys Lys Val Ile Ile Glu
                325                 330                 335     
Ile Leu Asp Glu Asn Asp Asn Ser Pro Glu Ile Ile Ile Thr Ser Leu
            340                 345                 350         
Ser Asp Gln Ile Leu Glu Asn Ser Pro Pro Gly Met Val Val Ala Leu
        355                 360                 365             
Phe Lys Thr Arg Asp Leu Asp Phe Gly Gly Asn Gly Glu Val Arg Cys
    370                 375                 380                 
Asn Ile Glu Thr Asp Ile Pro Phe Lys Ile Tyr Ser Ser Ser Asn Asn
385                 390                 395                 400 
Tyr Tyr Lys Leu Val Thr Asp Gly Ala Leu Asp Arg Glu Gln Thr Pro
                405                 410                 415     
Glu Tyr Asn Val Thr Ile Val Ala Thr Asp Arg Gly Lys Pro Pro Leu
            420                 425                 430         
Ser Ser Ser Arg Ser Ile Thr Leu Tyr Val Ala Asp Ile Asn Asp Asn
        435                 440                 445             
Ala Pro Val Phe Asp Gln Thr Ser Tyr Val Val His Val Ala Glu Asn
    450                 455                 460                 
Asn Pro Pro Gly Ala Ser Ile Ala Gln Val Ser Ala Ser Asp Pro Asp
465                 470                 475                 480 
Leu Gly Leu Asn Gly His Ile Ser Tyr Ser Ile Val Ala Ser Asp Leu
                485                 490                 495     
Glu Pro Leu Ala Val Ser Ser Tyr Val Ser Val Ser Ala Gln Ser Gly
            500                 505                 510         
Val Val Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe
        515                 520                 525             
Ala Leu Thr Leu Gln Ala Arg Asp His Gly Ser Pro Thr Leu Ser Ala
    530                 535                 540                 
Asn Val Ser Leu Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro
545                 550                 555                 560 
Arg Val Leu Tyr Pro Ala Leu Gly Pro Asp Gly Ser Ala Phe Phe Asp
                565                 570                 575     
Met Val Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Ala Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val
        595                 600                 605             
Leu Gln Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln
625                 630                 635                 640 
Arg Leu Leu Val Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Ala Thr Leu His Leu Val Phe Ala Asp Asn Leu Gln Glu Ile Leu
            660                 665                 670         
Pro Asp Leu Ser Asp Arg Pro Val Leu Ser Asp Pro Gln Ala Glu Leu
        675                 680                 685             
Gln Phe Tyr Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu
    690                 695                 700                 
Leu Ala Val Ile Leu Ala Ile Ala Leu Arg Leu Arg Arg Ser Leu Ser
705                 710                 715                 720 
Pro Ala Thr Trp Asp Cys Phe His Pro Gly Leu Cys Val Lys Ser Gly
                725                 730                 735     
Pro Val Val Pro Pro Asn Tyr Ser Glu Gly Thr Leu Pro Tyr Ser Tyr
            740                 745                 750         
Asn Leu Cys Ile Ala His Thr Gly Thr Lys Glu Phe Asn Phe Leu Lys
        755                 760                 765             
Cys Ser Val Pro Leu His Ser Asn Glu Asp Met Val Cys Ser Val Ser
    770                 775                 780                 
Pro Gly Ala Leu Ile Pro Pro His Gly Gly Glu Asp Leu Thr Ser His
785                 790                 795                 800 
Pro Glu Thr Leu Thr Ser Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe
                805                 810                 815     
Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp
            820                 825                 830         
Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala
        835                 840                 845             
Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu
    850                 855                 860                 
Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln
865                 870                 875                 880 
Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro
                885                 890                 895     
Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys
            900                 905                 910         
Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu
        915                 920                 925             
Lys Lys
    930 


<210> 6437
<211> 934
<212> PRT
<213> Homo sapiens

<400> 6437
Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val
 1               5                  10                  15      
Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val
            20                  25                  30          
Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly
        35                  40                  45              
Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg
    50                  55                  60                  
Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn
65                  70                  75                  80  
Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu
                85                  90                  95      
Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val
            100                 105                 110         
Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile
        115                 120                 125             
Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile
    130                 135                 140                 
Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His
145                 150                 155                 160 
Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg
                165                 170                 175     
Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys
            180                 185                 190         
Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro
        195                 200                 205             
Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu
    210                 215                 220                 
Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn
225                 230                 235                 240 
Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp
                245                 250                 255     
Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp
            260                 265                 270         
Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg
        275                 280                 285             
Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu
    290                 295                 300                 
Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile
305                 310                 315                 320 
Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys
                325                 330                 335     
Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile
            340                 345                 350         
Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly
        355                 360                 365             
Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn
    370                 375                 380                 
Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr
385                 390                 395                 400 
Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp
                405                 410                 415     
Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala
            420                 425                 430         
Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser
        435                 440                 445             
Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val
    450                 455                 460                 
Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser
465                 470                 475                 480 
Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu
                485                 490                 495     
Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile
            500                 505                 510         
Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu
        515                 520                 525             
Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr
    530                 535                 540                 
Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg
545                 550                 555                 560 
Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser
                565                 570                 575     
Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg
            580                 585                 590         
Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr
        595                 600                 605             
Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His
    610                 615                 620                 
Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro
625                 630                 635                 640 
Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu
                645                 650                 655     
Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu
            660                 665                 670         
Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys
        675                 680                 685             
Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly
    690                 695                 700                 
Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp
705                 710                 715                 720 
Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg
                725                 730                 735     
Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met
            740                 745                 750         
Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg
        755                 760                 765             
Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser
    770                 775                 780                 
Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val
785                 790                 795                 800 
Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Gln Ala Pro Pro Asn Thr
                805                 810                 815     
Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln
            820                 825                 830         
Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu
        835                 840                 845             
Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly
    850                 855                 860                 
Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg
865                 870                 875                 880 
Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn
                885                 890                 895     
Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys
            900                 905                 910         
Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser
        915                 920                 925             
Gly Lys Lys Glu Lys Lys
    930                 


<210> 6438
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6438
Met Ala Ala Pro Thr Lys Cys Gln Leu Arg Gly Arg Leu Val Leu Leu
 1               5                  10                  15      
Cys Ser Leu Leu Gly Met Leu Trp Glu Ala Arg Ala Ser Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Tyr Ile Val Gly Asn Ile
        35                  40                  45              
Ser Lys Asp Leu Ala Leu Glu Pro Arg Glu Leu Ala Glu Arg Arg Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Thr Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ser Pro Arg Cys Leu Val Asn Phe Lys Val Leu Val Glu Asp
            100                 105                 110         
Arg Val Lys Leu Tyr Gly Ile Glu Ile Glu Val Thr Asp Ile Asn Asp
        115                 120                 125             
Ser Ala Pro Lys Phe Gln Ala Glu Ser Leu Glu Val Lys Ile Asn Glu
    130                 135                 140                 
Ile Ala Val Pro Gly Ala Arg Tyr Pro Leu Pro Glu Ala Ile Asp Pro
145                 150                 155                 160 
Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn His
                165                 170                 175     
His Phe Ser Leu Asn Val Gln Thr Gly Asp Asn Gly Ala Ile Asn Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Glu Ala Thr Ala His
        195                 200                 205             
His Leu Val Leu Thr Ala Ser Asp Gly Gly Glu Pro Arg Arg Ser Ser
    210                 215                 220                 
Thr Val Arg Ile His Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro
225                 230                 235                 240 
Val Phe Ala Gln Arg Ile Tyr Arg Val Lys Val Leu Glu Asn Val Pro
                245                 250                 255     
Pro Gly Thr Trp Leu Leu Thr Ala Thr Ala Ser Asp Leu Asp Glu Gly
            260                 265                 270         
Ile Asn Gly Lys Val Ala Tyr Lys Phe Trp Lys Ile Asn Glu Lys Gln
        275                 280                 285             
Ser Leu Leu Phe Gln Leu Asn Glu Asn Thr Gly Glu Ile Ser Thr Ala
    290                 295                 300                 
Lys Ser Leu Asp Tyr Glu Glu Cys Ser Phe Tyr Glu Met Glu Ile Gln
305                 310                 315                 320 
Ala Glu Asp Gly Gly Gly Leu Lys Gly Trp Thr Lys Val Leu Ile Ser
                325                 330                 335     
Val Glu Asp Val Asn Asp Asn Arg Pro Glu Val Thr Ile Thr Ser Leu
            340                 345                 350         
Phe Ser Pro Val Arg Glu Asp Ala Pro Gln Gly Thr Val Ile Leu Leu
        355                 360                 365             
Phe Asn Ala His Asp Arg Asp Ser Gly Lys Asn Gly Gln Val Val Cys
    370                 375                 380                 
Ser Ile Gln Glu Asn Leu Ser Phe Thr Leu Glu Asn Ser Glu Glu Asp
385                 390                 395                 400 
Tyr Tyr Arg Leu Leu Thr Ala Gln Ile Leu Asp Arg Glu Lys Ala Ser
                405                 410                 415     
Glu Tyr Asn Ile Thr Val Thr Ala Thr Asp Arg Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Ile His Ile Thr Leu Gln Val Thr Asp Ile Asn Asp Asn
        435                 440                 445             
Pro Pro Ala Phe Ser Gln Ala Ser Tyr Ser Val Tyr Leu Pro Glu Asn
    450                 455                 460                 
Asn Ala Arg Gly Thr Ser Ile Phe Ser Val Ile Ala Tyr Asp Pro Asp
465                 470                 475                 480 
Ser Asn Glu Asn Ser Arg Val Ile Tyr Ser Leu Ala Glu Asp Thr Ile
                485                 490                 495     
Gln Gly Ser Pro Leu Ser Thr Tyr Val Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Cys Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu
        515                 520                 525             
Gln Met Gln Val Thr Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Arg Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Phe Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Ile Ala Asp Ser Ile Pro Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Gln Ile Pro Ala Asp Leu Glu Ala Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Val Val Ser Cys Val Phe
    690                 695                 700                 
Leu Thr Phe Val Ile Thr Leu Leu Ala Leu Arg Leu Arg His Trp His
705                 710                 715                 720 
Ser Ser His Leu Leu Arg Ala Thr Ser Asp Gly Leu Ala Gly Val Pro
                725                 730                 735     
Thr Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser Gln Glu Phe Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Gln Ser
    770                 775                 780                 
Cys Glu Lys Asn Glu Pro Leu Cys Val Ser Val Asp Ser Lys Phe Pro
785                 790                 795                 800 
Ile Glu Asp Thr Pro Leu Val Pro Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 6439
<211> 750
<212> PRT
<213> Homo sapiens

<400> 6439
Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu
 1               5                  10                  15      
Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile
            20                  25                  30          
Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn
        35                  40                  45              
Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly
    50                  55                  60                  
Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro
65                  70                  75                  80  
Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu
                85                  90                  95      
Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu
            100                 105                 110         
Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn
        115                 120                 125             
Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser
    130                 135                 140                 
Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp
145                 150                 155                 160 
Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn
                165                 170                 175     
Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn
            180                 185                 190         
Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala
        195                 200                 205             
His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys
    210                 215                 220                 
Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile
225                 230                 235                 240 
Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile
                245                 250                 255     
Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu
            260                 265                 270         
Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys
        275                 280                 285             
Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val
    290                 295                 300                 
Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile
305                 310                 315                 320 
Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile
                325                 330                 335     
Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser
            340                 345                 350         
Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala
        355                 360                 365             
Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser
    370                 375                 380                 
Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly
385                 390                 395                 400 
Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val
                405                 410                 415     
Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro
            420                 425                 430         
Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp
        435                 440                 445             
Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu
    450                 455                 460                 
Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro
465                 470                 475                 480 
Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr
                485                 490                 495     
Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr
            500                 505                 510         
Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp
        515                 520                 525             
Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser
    530                 535                 540                 
Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala
545                 550                 555                 560 
Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val
                565                 570                 575     
Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val
            580                 585                 590         
Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg
        595                 600                 605             
Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr
    610                 615                 620                 
Gly Glu Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln
625                 630                 635                 640 
Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp
                645                 650                 655     
Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala
            660                 665                 670         
Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala
        675                 680                 685             
Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln
    690                 695                 700                 
His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala
705                 710                 715                 720 
Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly
                725                 730                 735     
Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys
            740                 745                 750 


<210> 6440
<211> 931
<212> PRT
<213> Homo sapiens

<400> 6440
Met Lys Ala Ser Ser Gly Arg Cys Gly Leu Val Arg Trp Leu Gln Val
 1               5                  10                  15      
Leu Leu Pro Phe Leu Leu Ser Leu Phe Pro Gly Ala Leu Pro Val Gln
            20                  25                  30          
Ile Arg Tyr Ser Ile Pro Glu Glu Leu Ala Lys Asn Ser Val Val Gly
        35                  40                  45              
Asn Leu Ala Lys Asp Leu Gly Leu Ser Val Arg Asp Leu Pro Ala Arg
    50                  55                  60                  
Lys Leu Arg Val Ser Ala Glu Lys Glu Tyr Phe Thr Val Asn Pro Glu
65                  70                  75                  80  
Ser Gly Asp Leu Leu Val Ser Asp Arg Ile Asp Arg Glu Gln Ile Cys
                85                  90                  95      
Gly Lys Gln Pro Leu Cys Val Leu Asp Phe Asp Thr Val Ala Glu Asn
            100                 105                 110         
Pro Leu Asn Ile Phe Tyr Ile Ala Val Ile Val Gln Asp Ile Asn Asp
        115                 120                 125             
Asn Thr Pro Leu Phe Lys Gln Thr Lys Ile Asn Leu Lys Ile Gly Glu
    130                 135                 140                 
Ser Thr Lys Pro Gly Thr Thr Phe Pro Leu Asp Pro Ala Leu Asp Ser
145                 150                 155                 160 
Asp Val Gly Pro Asn Ser Leu Gln Arg Tyr His Leu Asn Asp Asn Glu
                165                 170                 175     
Tyr Phe Asp Leu Ala Glu Lys Gln Thr Pro Asp Gly Arg Lys Tyr Pro
            180                 185                 190         
Glu Leu Ile Leu Lys His Ser Leu Asp Arg Glu Glu His Ser Leu His
        195                 200                 205             
Gln Leu Val Leu Thr Ala Val Asp Gly Gly Asp Pro Pro Gln Ser Gly
    210                 215                 220                 
Thr Thr Gln Ile Arg Ile Lys Val Thr Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Val Phe Ser Gln Asp Val Tyr Arg Val Thr Leu Arg Glu Asp Val Pro
                245                 250                 255     
Pro Gly Phe Phe Val Leu Gln Val Thr Ala Thr Asp Arg Asp Glu Gly
            260                 265                 270         
Ile Asn Ala Glu Ile Thr Tyr Ser Phe His Asn Val Asp Glu Gln Val
        275                 280                 285             
Lys His Phe Phe Asn Leu Asn Glu Lys Thr Gly Glu Ile Thr Thr Lys
    290                 295                 300                 
Asp Asp Leu Asp Phe Glu Ile Ala Ser Ser Tyr Thr Leu Ser Ile Glu
305                 310                 315                 320 
Ala Lys Asp Pro Gly Asp Leu Ala Ala His Cys Ser Ile Gln Val Glu
                325                 330                 335     
Ile Leu Asp Asp Asn Asp Cys Ala Pro Glu Val Ile Val Thr Ser Val
            340                 345                 350         
Ser Thr Pro Leu Pro Glu Asp Ser Pro Pro Gly Thr Val Ile Ala Leu
        355                 360                 365             
Ile Lys Thr Arg Asp Arg Asp Ser Gly Glu Asn Gly Glu Val Tyr Cys
    370                 375                 380                 
Gln Val Leu Gly Asn Ala Lys Phe Ile Leu Lys Ser Ser Ser Lys Asn
385                 390                 395                 400 
Tyr Tyr Lys Leu Val Thr Asp Gly Ala Leu Asp Arg Glu Glu Ile Pro
                405                 410                 415     
Glu Tyr Asn Leu Thr Ile Thr Ala Thr Asp Gly Gly Lys Pro Pro Leu
            420                 425                 430         
Ser Ser Ser Ile Ile Val Thr Leu His Ile Ser Asp Val Asn Asp Asn
        435                 440                 445             
Ala Pro Val Phe Gln Gln Thr Ser Tyr Met Val His Val Ala Glu Asn
    450                 455                 460                 
Asn Pro Pro Gly Ala Ser Ile Ala Gln Ile Ser Ala Ser Asp Pro Asp
465                 470                 475                 480 
Leu Gly Pro Ser Gly Gln Val Ser Tyr Ser Ile Val Ala Ser Asp Leu
                485                 490                 495     
Lys Pro Arg Glu Ile Leu Ser Tyr Val Ser Val Ser Ala Gln Ser Gly
            500                 505                 510         
Val Val Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe
        515                 520                 525             
Glu Leu Thr Leu Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala
    530                 535                 540                 
Asn Val Ser Leu Arg Val Leu Val Gly Asp Leu Asn Asp Asn Ala Pro
545                 550                 555                 560 
Arg Val Leu Tyr Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp
                565                 570                 575     
Met Val Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Ala Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val
        595                 600                 605             
Leu Gln Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln
625                 630                 635                 640 
Arg Leu Leu Val Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Ala Thr Leu His Leu Ile Phe Ala Asp Ser Leu Gln Glu Val Leu
            660                 665                 670         
Pro Asp Leu Ser Asp Arg Arg Glu Pro Ser Asp Pro Gln Ala Lys Leu
        675                 680                 685             
Gln Phe Tyr Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Phe
    690                 695                 700                 
Leu Ala Val Ile Leu Ala Ile Ser Leu Arg Leu Arg Leu Ser Ser Arg
705                 710                 715                 720 
Ser Asp Ala Trp Asp Cys Phe Gln Pro Gly Leu Ser Ser Lys Pro Gly
                725                 730                 735     
Pro Gly Val Leu Pro Asn Tyr Ser Glu Gly Thr Leu Pro Tyr Ser Tyr
            740                 745                 750         
Asn Leu Cys Val Ala Ser Gln Ser Ala Lys Thr Glu Phe Asn Phe Leu
        755                 760                 765             
Asn Ile Thr Pro Glu Leu Val Pro Ala Gln Asp Leu Val Cys Asp Asn
    770                 775                 780                 
Ala Ser Trp Glu Gln Asn Thr Asn His Gly Ala Ala Gly Val Pro Phe
785                 790                 795                 800 
Ala Ser Asp Thr Ile Leu Lys Gln Ala Pro Pro Asn Thr Asp Trp Arg
                805                 810                 815     
Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp
            820                 825                 830         
Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln
        835                 840                 845             
Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr
    850                 855                 860                 
Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro
865                 870                 875                 880 
Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile
                885                 890                 895     
Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly
            900                 905                 910         
Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys
        915                 920                 925             
Glu Lys Lys
    930     


<210> 6441
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6441
Met Ala Ala Leu Gln Lys Leu Pro His Cys Arg Lys Leu Val Leu Leu
 1               5                  10                  15      
Cys Phe Leu Leu Ala Thr Leu Trp Glu Ala Arg Ala Gly Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Arg Glu Glu Ile Asp Arg Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Glu Pro Leu Ala Leu Ala Glu Gln Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Ser Gln Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Asn Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ser Ala Pro Cys Leu Leu Asn Phe Asn Ile Leu Leu Glu Asp
            100                 105                 110         
Lys Leu Thr Ile Tyr Ser Val Glu Val Glu Ile Thr Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Arg Phe Gly Val Glu Glu Leu Glu Leu Lys Ile Ser Glu
    130                 135                 140                 
Thr Thr Thr Pro Gly Phe Arg Ile Pro Leu Lys Asn Ala His Asp Ala
145                 150                 155                 160 
Asp Val Gly Glu Asn Ala Leu Gln Lys Tyr Ala Leu Asn Pro Asn Asp
                165                 170                 175     
His Phe Ser Leu Asp Val Arg Arg Gly Ala Asp Gly Asn Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Ser Leu Asp Arg Glu Glu Glu Ala Val His
        195                 200                 205             
His Leu Val Leu Val Ala Ser Asp Gly Gly Asp Pro Val Leu Ser Gly
    210                 215                 220                 
Thr Ser Arg Ile Cys Val Lys Val Leu Asp Ala Asn Asp Asn Ala Pro
225                 230                 235                 240 
Val Phe Thr Gln Pro Glu Tyr Arg Ile Ser Ile Pro Glu Asn Thr Leu
                245                 250                 255     
Val Gly Thr Arg Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Glu Gly
            260                 265                 270         
Tyr Tyr Ala Gln Val Val Tyr Phe Leu Glu Lys Ser Pro Gly Glu Thr
        275                 280                 285             
Ser Glu Val Phe Glu Leu Lys Ser Thr Ser Gly Glu Leu Thr Ile Ile
    290                 295                 300                 
Lys Asp Leu Asp Tyr Glu Asp Ala Thr Phe His Glu Ile Asp Ile Glu
305                 310                 315                 320 
Ala Gln Asp Gly Pro Gly Leu Leu Thr Arg Ala Lys Val Ile Val Thr
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Tyr Met Thr Ser Ala
            340                 345                 350         
Thr Ser Ser Val Ser Glu Asp Ser Leu Pro Gly Thr Ile Ile Gly Leu
        355                 360                 365             
Phe Asn Val His Asp Arg Asp Ser Gly Gln Asn Ala Phe Thr Thr Cys
    370                 375                 380                 
Ser Leu Pro Glu Asp Leu Pro Phe Lys Leu Glu Lys Ser Val Asp Asn
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Thr Arg Ala Leu Asp Arg Glu Gln Phe Ser
                405                 410                 415     
Phe Tyr Asn Ile Thr Leu Thr Ala Lys Asp Gly Gly Asn Pro Ser Leu
            420                 425                 430         
Ser Thr Asp Ala His Ile Leu Leu Gln Val Ala Asp Ile Asn Asp Asn
        435                 440                 445             
Ala Pro Ala Phe Ser Arg Thr Ser Tyr Ser Thr Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Val Phe Ser Val Thr Ala His Asp Pro Asp
465                 470                 475                 480 
Ser Asn Asp Asn Ala His Val Thr Tyr Ser Phe Ala Glu Asp Thr Val
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Tyr Ile Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Leu Arg Asp Leu
        515                 520                 525             
Gln Val Trp Val Ile Ala Arg Asp Ser Gly Asn Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Phe Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr His Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Ile Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Pro Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Ile Pro Asn Asp Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Ser Leu Thr Gly Met Gln
                725                 730                 735     
Ser Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser
    770                 775                 780                 
Cys Glu Lys Lys Asp Phe Leu Ser Ala Pro Gln Ser Leu Leu Glu Glu
785                 790                 795                 800 
Glu Arg Glu Glu Thr Phe Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 6442
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6442
Met Ala Pro Pro Gln Arg His Pro Gln Arg Ser Glu Gln Val Leu Leu
 1               5                  10                  15      
Leu Thr Leu Leu Gly Thr Leu Trp Gly Ala Ala Ala Ala Gln Ile Arg
            20                  25                  30          
Tyr Ser Ile Pro Glu Glu Leu Glu Lys Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Val Lys Asp Leu Gly Leu Glu Pro Gln Glu Leu Ala Glu His Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Met Gln Leu Phe Ser Leu Asn Pro Arg
65                  70                  75                  80  
Asn Gly Ser Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ser Pro Arg Cys Leu Val Ser Phe Asn Ile Leu Val Glu Asp
            100                 105                 110         
Lys Leu Asn Leu Tyr Pro Val Glu Val Glu Ile Val Asp Ile Asn Asp
        115                 120                 125             
Asn Thr Pro Arg Phe Leu Lys Glu Glu Leu Glu Val Lys Ile Leu Glu
    130                 135                 140                 
Asn Ala Ala Pro Ser Ser Arg Phe Pro Leu Met Glu Val Tyr Asp Pro
145                 150                 155                 160 
Asp Val Gly Met Asn Ser Leu Gln Gly Phe Lys Leu Ser Gly Asn Ser
                165                 170                 175     
His Phe Ser Val Asp Val Gln Ser Glu Ala His Gly Pro Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Gly Thr Leu Asp Arg Glu Gly Glu Ala Val Tyr
        195                 200                 205             
Arg Leu Val Leu Thr Ala Met Asp Gly Gly Asp Pro Val Arg Ser Ser
    210                 215                 220                 
Val Ala Gln Ile Leu Val Thr Val Leu Asp Val Asn Asp Asn Thr Pro
225                 230                 235                 240 
Met Phe Thr Gln Pro Val Tyr Arg Val Ser Val Pro Glu Asn Leu Pro
                245                 250                 255     
Val Gly Thr Pro Val Leu Ala Val Thr Ala Thr Asp Gln Asp Glu Gly
            260                 265                 270         
Val His Gly Glu Val Thr Tyr Ser Phe Val Lys Ile Thr Glu Lys Ile
        275                 280                 285             
Ser Gln Ile Phe Cys Leu Asn Val Leu Thr Gly Glu Ile Ser Thr Ser
    290                 295                 300                 
Ala Asn Leu Asp Tyr Glu Asp Ser Ser Phe Tyr Glu Leu Gly Val Glu
305                 310                 315                 320 
Ala Arg Asp Gly Pro Gly Leu Arg Asp Arg Ala Lys Val Leu Ile Thr
                325                 330                 335     
Ile Leu Asp Val Asn Asp Asn Val Pro Glu Val Val Val Thr Ser Gly
            340                 345                 350         
Ser Arg Thr Ile Ala Glu Ser Ala Pro Pro Gly Thr Val Ile Ala Leu
        355                 360                 365             
Phe Gln Val Phe Asp Arg Asp Ser Gly Leu Asn Gly Leu Val Thr Cys
    370                 375                 380                 
Ser Ile Pro Arg Ser Leu Pro Phe Glu Leu Glu Lys Ser Val Gly Asn
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Asn Ala Ala Leu Asp Arg Glu Glu Val Phe
                405                 410                 415     
Leu Tyr Asn Ile Thr Val Thr Ala Thr Asp Lys Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Thr Ile Ile Ser Leu Asn Val Ala Asp Thr Asn Asp Asn
        435                 440                 445             
Pro Pro Thr Phe Pro His Ser Ser Tyr Ser Val Tyr Val Leu Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Asn Ala Leu Asp Pro Asp
465                 470                 475                 480 
Val Asp Gln Asn Ala Gln Val Ser Tyr Ser Leu Ala Glu Asp Thr Leu
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Ile Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Leu Arg Asp Leu
        515                 520                 525             
Gln Leu Trp Val Thr Ala Ser Asp Ser Gly Asp Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Pro Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Val Leu Leu Ala Leu Arg Leu Gln Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Met Pro
                725                 730                 735     
Gly Ser His Phe Val Gly Val Glu Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Asn Gln Glu Ser
    770                 775                 780                 
Tyr Glu Lys Ser Glu Pro Leu Leu Ile Thr Gln Asp Leu Leu Glu Thr
785                 790                 795                 800 
Lys Gly Glu Pro Arg Gln Leu Gln Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 6443
<211> 938
<212> PRT
<213> Homo sapiens

<400> 6443
Met Leu Arg Lys Val Arg Ser Trp Thr Glu Ile Trp Arg Trp Ala Thr
 1               5                  10                  15      
Leu Leu Phe Leu Phe Tyr His Leu Gly Tyr Val Cys Gly Gln Ile Arg
            20                  25                  30          
Tyr Pro Val Pro Glu Glu Ser Gln Glu Gly Thr Phe Val Gly Asn Val
        35                  40                  45              
Ala Gln Asp Phe Leu Leu Asp Thr Asp Ser Leu Ser Ala Arg Arg Leu
    50                  55                  60                  
Gln Val Ala Gly Glu Val Asn Gln Arg His Phe Arg Val Asp Leu Asp
65                  70                  75                  80  
Ser Gly Ala Leu Leu Ile Lys Asn Pro Ile Asp Arg Glu Ala Leu Cys
                85                  90                  95      
Gly Leu Ser Ala Ser Cys Ile Val Pro Leu Glu Phe Val Thr Glu Gly
            100                 105                 110         
Pro Leu Glu Met Tyr Arg Ala Glu Val Glu Ile Val Asp Val Asn Asp
        115                 120                 125             
His Ala Pro Arg Phe Pro Arg Gln Gln Leu Asp Leu Glu Ile Gly Glu
    130                 135                 140                 
Ala Ala Pro Pro Gly Gln Arg Phe Pro Leu Glu Lys Ala Gln Asp Ala
145                 150                 155                 160 
Asp Val Gly Ser Asn Ser Ile Ser Ser Tyr Arg Leu Ser Ser Asn Glu
                165                 170                 175     
His Phe Ala Leu Asp Val Lys Lys Arg Ser Asp Gly Ser Leu Val Pro
            180                 185                 190         
Glu Leu Leu Leu Glu Lys Pro Leu Asp Arg Glu Lys Gln Ser Asp Tyr
        195                 200                 205             
Arg Leu Val Leu Thr Ala Val Asp Gly Gly Asn Pro Pro Arg Ser Gly
    210                 215                 220                 
Thr Ala Glu Leu Arg Val Ser Val Leu Asp Val Asn Asp Asn Ala Pro
225                 230                 235                 240 
Ala Phe Gln Gln Ser Ser Tyr Arg Ile Ser Val Leu Glu Ser Ala Pro
                245                 250                 255     
Ala Gly Met Val Leu Ile Gln Leu Asn Ala Ser Asp Pro Asp Leu Gly
            260                 265                 270         
Pro Ser Gly Asn Val Thr Phe Tyr Phe Ser Gly His Thr Pro Asp Arg
        275                 280                 285             
Val Arg Asn Leu Phe Ser Leu His Pro Thr Thr Gly Lys Leu Thr Leu
    290                 295                 300                 
Leu Gly Pro Leu Asp Phe Glu Ser Glu Asn Tyr Tyr Glu Phe Asp Val
305                 310                 315                 320 
Arg Ala Arg Asp Gly Gly Ser Pro Ala Met Glu Gln His Cys Ser Leu
                325                 330                 335     
Arg Val Asp Leu Leu Asp Val Asn Asp Asn Ala Pro Tyr Ile Thr Val
            340                 345                 350         
Thr Ser Glu Leu Gly Thr Leu Pro Glu Ser Ala Glu Pro Gly Thr Val
        355                 360                 365             
Val Ala Leu Ile Ser Val Gln Asp Pro Asp Ser Gly Ser Asn Gly Asp
    370                 375                 380                 
Val Ser Leu Arg Ile Pro Asp His Leu Pro Phe Ala Leu Lys Ser Ala
385                 390                 395                 400 
Phe Arg Asn Gln Phe Ser Leu Val Thr Ala Gly Pro Leu Asp Arg Glu
                405                 410                 415     
Ala Lys Ser Ser Tyr Asp Ile Met Val Thr Ala Ser Asp Ala Gly Asn
            420                 425                 430         
Pro Pro Leu Ser Thr His Arg Thr Ile Phe Leu Asn Ile Ser Asp Val
        435                 440                 445             
Asn Asp Asn Pro Pro Ser Phe Phe Gln Arg Ser His Glu Val Phe Val
    450                 455                 460                 
Pro Glu Asn Asn Arg Pro Gly Asp Leu Leu Cys Ser Leu Ala Ala Ser
465                 470                 475                 480 
Asp Pro Asp Ser Gly Leu Asn Ala Leu Ile Ser Tyr Ser Leu Leu Glu
                485                 490                 495     
Pro Arg Asn Arg Asp Val Ser Ala Ser Ser Phe Ile Ser Leu Asn Pro
            500                 505                 510         
Gln Thr Gly Ala Val His Ala Thr Arg Ser Phe Asp Tyr Glu Gln Thr
        515                 520                 525             
Gln Thr Leu Gln Phe Glu Val Gln Ala Arg Asp Arg Gly Asn Pro Pro
    530                 535                 540                 
Leu Ser Ser Thr Val Thr Val Arg Leu Phe Val Leu Asp Leu Asn Asp
545                 550                 555                 560 
Asn Ala Pro Ala Val Leu Arg Pro Arg Ala Arg Pro Gly Ser Leu Cys
                565                 570                 575     
Pro Gln Ala Leu Pro Pro Ser Val Gly Ala Gly His Leu Ile Thr Lys
            580                 585                 590         
Val Thr Ala Val Asp Leu Asp Ser Gly Tyr Asn Ala Trp Val Ser Tyr
        595                 600                 605             
Gln Leu Leu Glu Ala Pro Asp Pro Ser Leu Phe Ala Val Ser Arg Tyr
    610                 615                 620                 
Ala Gly Glu Val Arg Thr Ala Val Pro Ile Pro Ala Asp Leu Pro Pro
625                 630                 635                 640 
Gln Lys Leu Val Ile Val Val Lys Asp Ser Gly Ser Pro Pro Leu Ser
                645                 650                 655     
Thr Ser Val Thr Leu Leu Val Ser Leu Glu Glu Asp Thr His Pro Val
            660                 665                 670         
Val Pro Asp Leu Arg Glu Ser Ser Ala Pro Arg Glu Gly Glu Ser Arg
        675                 680                 685             
Leu Thr Leu Tyr Leu Ala Val Ser Leu Val Ala Ile Cys Phe Val Ser
    690                 695                 700                 
Phe Gly Ser Phe Val Ala Leu Leu Ser Lys Cys Leu Arg Gly Ala Ala
705                 710                 715                 720 
Cys Gly Val Thr Cys Phe Pro Ala Gly Thr Cys Ala Cys Leu Thr Arg
                725                 730                 735     
Ser Arg Arg Arg Glu Gly Leu Pro Pro Ser Asn Gly Ile Leu Arg Ile
            740                 745                 750         
Gln Leu Gly Ser Asp Asp Pro Ile Lys Phe Val Asp Val Gly Gly His
        755                 760                 765             
Ser His Gly Cys Thr Pro Leu Ala Ser Ala Pro Thr Arg Ser Asp Ser
    770                 775                 780                 
Phe Met Met Val Lys Ser Pro Ser Ala Pro Met Ala Gly Glu Pro Val
785                 790                 795                 800 
Arg Pro Ser Cys Pro Pro Ser Asp Leu Leu Tyr Gly Leu Glu Gln Ala
                805                 810                 815     
Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr
            820                 825                 830         
Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln
        835                 840                 845             
Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu
    850                 855                 860                 
Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly
865                 870                 875                 880 
Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp
                885                 890                 895     
Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn
            900                 905                 910         
Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn
        915                 920                 925             
Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys
    930                 935             


<210> 6444
<211> 931
<212> PRT
<213> Homo sapiens

<400> 6444
Met Ala Ala Pro Pro Ala Arg Pro Asp His Thr Arg Leu Leu Gln Ile
 1               5                  10                  15      
Cys Leu Leu Leu Gly Val Leu Val Glu Ile Arg Ala Glu Gln Ile Leu
            20                  25                  30          
Tyr Ser Val Phe Glu Glu Gln Glu Glu Gly Ser Val Val Gly Asn Ile
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Ala Pro Arg Glu Leu Ala Glu Arg Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Thr Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Asp Arg Ser Pro Asn Cys Val Thr Asn Leu Glu Ile Leu Leu Glu Asp
            100                 105                 110         
Thr Val Lys Ile Leu Arg Val Glu Val Glu Ile Ile Asp Val Asn Asp
        115                 120                 125             
Asn Pro Pro Ser Phe Gly Thr Glu Gln Arg Glu Ile Lys Val Ala Glu
    130                 135                 140                 
Asn Glu Asn Pro Gly Ala Arg Phe Pro Leu Pro Glu Ala Phe Asp Pro
145                 150                 155                 160 
Asp Val Gly Val Asn Ser Leu Gln Gly Tyr Gln Leu Asn Ser Asn Gly
                165                 170                 175     
Tyr Phe Ser Leu Asp Val Gln Ser Gly Ala Asp Gly Ile Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Glu Glu Ala Val His
        195                 200                 205             
His Leu Val Leu Thr Ala Phe Asp Gly Gly Asp Pro Val Arg Ser Gly
    210                 215                 220                 
Thr Ala Arg Ile Leu Ile Ile Leu Val Asp Thr Asn Asp Asn Ala Pro
225                 230                 235                 240 
Val Phe Thr Gln Pro Glu Tyr His Val Ser Val Arg Glu Asn Val Pro
                245                 250                 255     
Val Gly Thr Arg Leu Leu Thr Val Lys Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Ala Asn Gly Asp Val Thr Tyr Ser Phe Arg Lys Val Arg Asp Lys Ile
        275                 280                 285             
Ser Gln Leu Phe Gln Leu Asn Ser Leu Ser Gly Asp Ile Thr Ile Leu
    290                 295                 300                 
Gly Gly Leu Asp Tyr Glu Asp Ser Gly Phe Tyr Asp Ile Asp Val Glu
305                 310                 315                 320 
Ala His Asp Gly Pro Gly Leu Arg Ala Arg Ser Lys Val Leu Val Thr
                325                 330                 335     
Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Val Thr Val Thr Ser Leu
            340                 345                 350         
Thr Ser Ser Val Gln Glu Ser Ser Ser Pro Gly Thr Val Ile Ala Leu
        355                 360                 365             
Phe Asn Val His Asp Ser Asp Ser Gly Gly Asn Gly Leu Val Thr Cys
    370                 375                 380                 
Ser Ile Pro Asp Asn Leu Pro Phe Thr Leu Glu Lys Thr Tyr Gly Asn
385                 390                 395                 400 
Tyr Tyr Arg Leu Leu Thr His Arg Thr Leu Asp Arg Glu Glu Val Ser
                405                 410                 415     
Glu Tyr Asn Ile Thr Val Thr Ala Thr Asp Gln Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Thr His Ile Ser Leu Gln Val Met Asp Ile Asn Asp Asn
        435                 440                 445             
Pro Pro Thr Phe Pro His Ala Ser Tyr Ser Ala Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Ile Leu Ser Met Thr Ala Gln Asp Pro Asp
465                 470                 475                 480 
Ser Gly Asp Asn Ala Arg Ile Thr Tyr Ser Leu Ala Glu Asp Thr Phe
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr Gly
            500                 505                 510         
Ile Leu Tyr Ala Leu Cys Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu
        515                 520                 525             
Gln Leu Leu Met Thr Ala Ser Asp Ser Gly Asp Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Val Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Thr Phe Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Asp Ser Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Ser Leu
        595                 600                 605             
Leu Lys Ser Ser Glu Pro Gly Leu Phe Ala Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Arg Leu Val Val Val Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Asp Val Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Lys Pro Ser Ala Asp Pro Asp Asp Ser Gly
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Thr Val Leu Leu Ala Leu Lys Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu His Ala Glu Gly Ser Arg Leu Ala Gly Val Pro
                725                 730                 735     
Ala Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Ser Gln Pro Ser Tyr Ala Asp Thr Leu Ile Ser Arg Glu Ser
    770                 775                 780                 
Cys Glu Lys Ser Glu Pro Leu Leu Ile Thr Gln Asp Leu Leu Glu Thr
785                 790                 795                 800 
Lys Gly Asp Pro Asn Leu Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg
                805                 810                 815     
Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp
            820                 825                 830         
Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln
        835                 840                 845             
Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr
    850                 855                 860                 
Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro
865                 870                 875                 880 
Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile
                885                 890                 895     
Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly
            900                 905                 910         
Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys
        915                 920                 925             
Glu Lys Lys
    930     


<210> 6445
<211> 134
<212> PRT
<213> Homo sapiens

<400> 6445
Met Val Pro Glu Ala Trp Arg Ser Gly Leu Gln Ala Pro Pro Asn Thr
 1               5                  10                  15      
Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln
            20                  25                  30          
Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu
        35                  40                  45              
Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly
    50                  55                  60                  
Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg
65                  70                  75                  80  
Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn
                85                  90                  95      
Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys
            100                 105                 110         
Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser
        115                 120                 125             
Gly Lys Lys Glu Lys Lys
    130                 


<210> 6446
<211> 929
<212> PRT
<213> Homo sapiens

<400> 6446
Met Gly Gly Ser Cys Ala Gln Arg Arg Arg Ala Gly Pro Arg Gln Val
 1               5                  10                  15      
Leu Phe Pro Leu Leu Leu Pro Leu Phe Tyr Pro Thr Leu Cys Glu Pro
            20                  25                  30          
Ile Arg Tyr Ser Ile Pro Glu Glu Leu Ala Lys Gly Ser Val Val Gly
        35                  40                  45              
Asn Leu Ala Lys Asp Leu Gly Leu Ser Val Leu Asp Val Ser Ala Arg
    50                  55                  60                  
Glu Leu Arg Val Ser Ala Glu Lys Leu His Phe Ser Val Asp Ala Gln
65                  70                  75                  80  
Ser Gly Asp Leu Leu Val Lys Asp Arg Ile Asp Arg Glu Gln Ile Cys
                85                  90                  95      
Lys Glu Arg Arg Arg Cys Glu Leu Gln Leu Glu Ala Val Val Glu Asn
            100                 105                 110         
Pro Leu Asn Ile Phe His Val Ile Val Val Ile Glu Asp Val Asn Asp
        115                 120                 125             
His Ala Pro Gln Phe Arg Lys Asp Glu Ile Asn Leu Glu Ile Ser Glu
    130                 135                 140                 
Ser Val Ser Leu Gly Met Gly Thr Ile Leu Glu Ser Ala Glu Asp Pro
145                 150                 155                 160 
Asp Ile Ser Met Asn Ser Leu Ser Lys Tyr Gln Leu Ser Pro Asn Glu
                165                 170                 175     
Tyr Phe Ser Leu Val Glu Lys Asp Asn Pro Asp Gly Gly Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Gln Lys Thr Leu Asp Arg Glu Thr Gln Ser Ala His
        195                 200                 205             
His Leu Val Leu Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Ser Gly
    210                 215                 220                 
Thr Ala Gln Ile Arg Ile Leu Val Ile Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Val Phe Ser Gln Asp Val Tyr Arg Val Ser Leu Arg Glu Asp Val Pro
                245                 250                 255     
Pro Gly Thr Ser Ile Leu Arg Val Lys Ala Thr Asp Gln Asp Glu Gly
            260                 265                 270         
Ile Asn Ser Glu Ile Thr Tyr Ser Phe Phe Gly Val Ala Asp Lys Ala
        275                 280                 285             
Gln His Val Phe Ser Leu Asp Tyr Thr Thr Gly Asn Ile Leu Thr Gln
    290                 295                 300                 
Gln Pro Leu Asp Phe Glu Glu Val Glu Arg Tyr Thr Ile Asn Ile Glu
305                 310                 315                 320 
Ala Lys Asp Arg Gly Ser Leu Ser Thr Arg Cys Lys Val Ile Val Glu
                325                 330                 335     
Val Val Asp Glu Asn Asp Asn Ser Pro Glu Ile Ile Ile Thr Ser Leu
            340                 345                 350         
Ser Asp Gln Ile Met Glu Asp Ser Pro Pro Gly Val Val Val Ala Leu
        355                 360                 365             
Phe Lys Thr Arg Asp Gln Asp Ser Gly Glu Asn Gly Glu Val Arg Cys
    370                 375                 380                 
Ser Leu Ser Arg Gly Val Pro Phe Lys Ile His Ser Ser Ser Asn Asn
385                 390                 395                 400 
Tyr Tyr Lys Leu Val Thr Asp Glu Ala Leu Asp Arg Glu Gln Thr Pro
                405                 410                 415     
Glu Tyr Asn Val Thr Ile Ala Ala Thr Asp Arg Gly Lys Pro Pro Leu
            420                 425                 430         
Ser Ser Ser Lys Thr Ile Thr Leu His Ile Thr Asp Val Asn Asp Asn
        435                 440                 445             
Ala Pro Val Phe Gly Gln Ser Ala Tyr Leu Val His Val Pro Glu Asn
    450                 455                 460                 
Asn Gln Pro Gly Ala Ser Ile Ala Gln Val Ser Ala Ser Asp Pro Asp
465                 470                 475                 480 
Phe Gly Leu Asn Gly Arg Val Ser Tyr Ser Leu Ile Ala Ser Asp Leu
                485                 490                 495     
Glu Ser Arg Thr Leu Ser Ser Tyr Val Ser Val Ser Ala Gln Ser Gly
            500                 505                 510         
Val Val Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Thr Phe
        515                 520                 525             
Glu Leu Thr Leu Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala
    530                 535                 540                 
Asn Val Ser Leu Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro
545                 550                 555                 560 
Arg Val Leu Tyr Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp
                565                 570                 575     
Thr Val Pro Arg Ala Ala Gln Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Ala Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val
        595                 600                 605             
Val Gln Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly
    610                 615                 620                 
Glu Val Arg Met Val Arg Ala Leu Gly Asp Lys Asp Ser Val Arg Gln
625                 630                 635                 640 
Arg Leu Leu Val Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Ala Thr Leu His Leu Val Phe Ala Asp Ser Leu Gln Glu Val Leu
            660                 665                 670         
Pro Asp Phe Ser Asp His Pro Thr Pro Ser Asp Ser Gln Ala Glu Met
        675                 680                 685             
Gln Phe Tyr Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu
    690                 695                 700                 
Leu Ala Val Ile Leu Ala Ile Ala Leu Arg Leu Arg Gln Ser Phe Ser
705                 710                 715                 720 
Pro Thr Ala Gly Asp Cys Phe Glu Ser Val Leu Cys Ser Lys Ser Gly
                725                 730                 735     
Pro Val Gly Pro Pro Asn Tyr Ser Glu Gly Thr Leu Pro Tyr Ala Tyr
            740                 745                 750         
Asn Phe Cys Val Pro Gly Asp Gln Met Asn Pro Glu Phe Asn Phe Phe
        755                 760                 765             
Thr Ser Val Asp His Cys Pro Ala Thr Gln Asp Asn Leu Asn Lys Asp
    770                 775                 780                 
Ser Met Leu Leu Ala Ser Ile Leu Thr Pro Ser Val Glu Ala Asp Lys
785                 790                 795                 800 
Lys Ile Leu Lys Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser
                805                 810                 815     
Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr
            820                 825                 830         
Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met
        835                 840                 845             
Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly
    850                 855                 860                 
Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe
865                 870                 875                 880 
Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly
                885                 890                 895     
Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala
            900                 905                 910         
Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys
        915                 920                 925             
Lys
    


<210> 6447
<211> 931
<212> PRT
<213> Homo sapiens

<400> 6447
Met Ala Ser Pro Pro Arg Gly Trp Gly Cys Gly Glu Leu Leu Leu Pro
 1               5                  10                  15      
Phe Met Leu Leu Gly Thr Leu Cys Glu Pro Gly Ser Gly Gln Ile Arg
            20                  25                  30          
Tyr Ser Met Pro Glu Glu Leu Asp Lys Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Glu Pro Gln Glu Leu Ala Glu Arg Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ser Pro Leu Cys Val Val Asn Phe Asn Ile Leu Val Glu Asn
            100                 105                 110         
Lys Met Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn Asp
        115                 120                 125             
Asn Phe Pro Arg Phe Arg Asp Glu Glu Leu Lys Val Lys Val Asn Glu
    130                 135                 140                 
Asn Ala Ala Ala Gly Thr Arg Leu Val Leu Pro Phe Ala Arg Asp Ala
145                 150                 155                 160 
Asp Val Gly Val Asn Ser Leu Arg Ser Tyr Gln Leu Ser Ser Asn Leu
                165                 170                 175     
His Phe Ser Leu Asp Val Val Ser Gly Thr Asp Gly Gln Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Gln Pro Leu Asp Arg Glu Lys Glu Thr Val His
        195                 200                 205             
Asp Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Val Leu Ser Gly
    210                 215                 220                 
Thr Thr His Ile Arg Val Thr Val Leu Asp Ala Asn Asp Asn Ala Pro
225                 230                 235                 240 
Leu Phe Thr Pro Ser Glu Tyr Ser Val Ser Val Pro Glu Asn Ile Pro
                245                 250                 255     
Val Gly Thr Arg Leu Leu Met Leu Thr Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Ile Asn Gly Lys Leu Thr Tyr Ser Phe Arg Asn Glu Glu Glu Lys Ile
        275                 280                 285             
Ser Glu Thr Phe Gln Leu Asp Ser Asn Leu Gly Glu Ile Ser Thr Leu
    290                 295                 300                 
Gln Ser Leu Asp Tyr Glu Glu Ser Arg Phe Tyr Leu Met Glu Val Val
305                 310                 315                 320 
Ala Gln Asp Gly Gly Ala Leu Val Ala Ser Ala Lys Val Val Val Thr
                325                 330                 335     
Val Gln Asp Val Asn Asp Asn Ala Pro Glu Val Ile Leu Thr Ser Leu
            340                 345                 350         
Thr Ser Ser Ile Ser Glu Asp Cys Leu Pro Gly Thr Val Ile Ala Leu
        355                 360                 365             
Phe Ser Val His Asp Gly Asp Ser Gly Glu Asn Gly Glu Ile Ala Cys
    370                 375                 380                 
Ser Ile Pro Arg Asn Leu Pro Phe Lys Leu Glu Lys Ser Val Asp Asn
385                 390                 395                 400 
Tyr Tyr His Leu Leu Thr Thr Arg Asp Leu Asp Arg Glu Glu Thr Ser
                405                 410                 415     
Asp Tyr Asn Ile Thr Leu Thr Val Met Asp His Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Ser His Ile Pro Leu Lys Val Ala Asp Val Asn Asp Asn
        435                 440                 445             
Pro Pro Asn Phe Pro Gln Ala Ser Tyr Ser Thr Ser Val Thr Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Val Ser Ile Phe Ser Val Thr Ala His Asp Pro Asp
465                 470                 475                 480 
Ser Gly Asp Asn Ala Arg Val Thr Tyr Ser Leu Ala Glu Asp Thr Phe
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Leu Arg Asp Leu
        515                 520                 525             
Gln Leu Trp Val Thr Ala Ser Asp Ser Gly Asn Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Thr Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Glu Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Phe Thr Val Thr Val Ala Val Ala Asp Arg Ile Pro Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Ile Lys Thr Pro Ile Asp Pro Glu Asp Leu Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Val Leu Leu Val Leu Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Glu Gly Ser Arg Leu Ala Gly Val Pro
                725                 730                 735     
Ala Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Leu Ser Glu Glu Ser
    770                 775                 780                 
Cys Glu Lys Ser Glu Pro Leu Leu Met Ser Asp Lys Val Asp Ala Asn
785                 790                 795                 800 
Lys Glu Glu Arg Arg Val Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg
                805                 810                 815     
Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp
            820                 825                 830         
Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln
        835                 840                 845             
Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr
    850                 855                 860                 
Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro
865                 870                 875                 880 
Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile
                885                 890                 895     
Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly
            900                 905                 910         
Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys
        915                 920                 925             
Glu Lys Lys
    930     


<210> 6448
<211> 929
<212> PRT
<213> Homo sapiens

<400> 6448
Met Gly Asn Ser Ser Gly Trp Arg Gly Pro Ala Gly Gln Arg Arg Met
 1               5                  10                  15      
Leu Phe Leu Phe Leu Leu Ser Leu Leu Asp Gln Val Leu Ser Glu Pro
            20                  25                  30          
Ile Arg Tyr Ala Ile Pro Glu Glu Leu Asp Arg Gly Ser Leu Val Gly
        35                  40                  45              
Asn Leu Ala Lys Asp Leu Gly Phe Gly Val Gly Asp Leu Pro Thr Arg
    50                  55                  60                  
Asn Leu Arg Val Ile Ala Glu Lys Lys Phe Phe Thr Val Ser Pro Glu
65                  70                  75                  80  
Asn Gly Asn Leu Leu Val Ser Asp Arg Ile Asp Arg Glu Glu Ile Cys
                85                  90                  95      
Gly Lys Lys Ser Thr Cys Val Leu Glu Phe Glu Met Val Ala Glu Lys
            100                 105                 110         
Pro Leu Asn Phe Phe His Val Thr Val Leu Ile Gln Asp Ile Asn Asp
        115                 120                 125             
Asn Pro Pro Thr Phe Ser Gln Asn Ile Thr Glu Leu Glu Ile Ser Glu
    130                 135                 140                 
Leu Ala Leu Thr Gly Ala Thr Phe Ala Leu Glu Ser Ala Gln Asp Pro
145                 150                 155                 160 
Asp Val Gly Val Asn Ser Leu Gln Gln Tyr Tyr Leu Ser Pro Asp Pro
                165                 170                 175     
His Phe Ser Leu Ile Gln Lys Glu Asn Leu Asp Gly Ser Arg Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Lys Ala Pro Leu Asp Arg Glu Glu Gln Pro His His
        195                 200                 205             
His Leu Val Leu Thr Ala Val Asp Gly Gly Glu Pro Ser Arg Ser Cys
    210                 215                 220                 
Thr Thr Gln Ile Arg Val Ile Val Ala Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Val Phe Thr Gln Asp Met Tyr Arg Val Asn Val Ala Glu Asn Leu Pro
                245                 250                 255     
Ala Gly Ser Ser Val Leu Lys Val Met Ala Ile Asp Met Asp Glu Gly
            260                 265                 270         
Ile Asn Ala Glu Ile Ile Tyr Ala Phe Ile Asn Ile Gly Lys Glu Val
        275                 280                 285             
Arg Gln Leu Phe Lys Leu Asp Ser Lys Thr Gly Glu Leu Thr Thr Ile
    290                 295                 300                 
Gly Glu Leu Asp Phe Glu Glu Arg Asp Ser Tyr Thr Ile Gly Val Glu
305                 310                 315                 320 
Ala Lys Asp Gly Gly His His Thr Ala Tyr Cys Lys Val Gln Ile Asp
                325                 330                 335     
Ile Ser Asp Glu Asn Asp Asn Ala Pro Glu Ile Thr Leu Ala Ser Glu
            340                 345                 350         
Ser Gln His Ile Gln Glu Asp Ala Glu Leu Gly Thr Ala Val Ala Leu
        355                 360                 365             
Ile Lys Thr His Asp Leu Asp Ser Gly Phe Asn Gly Glu Ile Leu Cys
    370                 375                 380                 
Gln Leu Lys Gly Asn Phe Pro Phe Lys Ile Val Gln Asp Thr Lys Asn
385                 390                 395                 400 
Thr Tyr Arg Leu Val Thr Asp Gly Ala Leu Asp Arg Glu Gln Ile Pro
                405                 410                 415     
Glu Tyr Asn Val Thr Ile Thr Ala Thr Asp Lys Gly Asn Pro Pro Leu
            420                 425                 430         
Ser Ser Ser Lys Thr Ile Thr Leu His Ile Leu Asp Val Asn Asp Asn
        435                 440                 445             
Val Pro Val Phe His Gln Ala Ser Tyr Thr Val His Val Ala Glu Asn
    450                 455                 460                 
Asn Pro Pro Gly Ala Ser Ile Ala His Val Arg Ala Ser Asp Pro Asp
465                 470                 475                 480 
Leu Gly Pro Asn Gly Leu Val Ser Tyr Tyr Ile Val Ala Ser Asp Leu
                485                 490                 495     
Glu Pro Arg Glu Leu Ser Ser Tyr Val Ser Val Ser Ala Arg Ser Gly
            500                 505                 510         
Val Val Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe
        515                 520                 525             
Glu Leu Thr Leu Gln Ala Arg Asp Gln Gly Ser Pro Thr Leu Ser Ala
    530                 535                 540                 
Asn Val Ser Leu Arg Val Leu Val Asp Asp Arg Asn Asp Asn Ala Pro
545                 550                 555                 560 
Leu Val Leu Tyr Pro Ala Leu Gly Pro Glu Gly Ser Ala Leu Phe Asp
                565                 570                 575     
Met Val Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr His Ile
        595                 600                 605             
Val Gln Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Thr Leu Gly Asp Arg Glu Ala Ala Arg Gln
625                 630                 635                 640 
Arg Leu Leu Val Thr Val Arg Asp Gly Gly Gln Gln Pro Leu Ser Ala
                645                 650                 655     
Thr Val Met Leu His Leu Ile Phe Ala Asp Ser Leu Gln Glu Ile Gln
            660                 665                 670         
Pro Asp Leu Ser Asp Arg Pro Thr Pro Ser Asp Pro Gln Ala Glu Leu
        675                 680                 685             
Gln Phe His Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu
    690                 695                 700                 
Leu Ala Val Ile Leu Ala Ile Ser Leu Arg Leu Arg Cys Ser Ser Arg
705                 710                 715                 720 
Pro Ala Thr Glu Gly Tyr Phe Gln Pro Gly Val Cys Phe Lys Thr Val
                725                 730                 735     
Pro Gly Val Leu Pro Thr Tyr Ser Glu Arg Thr Leu Pro Tyr Ser Tyr
            740                 745                 750         
Asn Pro Cys Ala Ala Ser His Ser Ser Asn Thr Glu Phe Lys Phe Leu
        755                 760                 765             
Asn Ile Lys Ala Glu Asn Ala Ala Pro Gln Asp Leu Leu Cys Asp Glu
    770                 775                 780                 
Ala Ser Trp Phe Glu Ser Asn Asp Asn Pro Glu Met Pro Ser Asn Ser
785                 790                 795                 800 
Gly Asn Leu Gln Lys Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser
                805                 810                 815     
Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr
            820                 825                 830         
Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met
        835                 840                 845             
Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly
    850                 855                 860                 
Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe
865                 870                 875                 880 
Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly
                885                 890                 895     
Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala
            900                 905                 910         
Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys
        915                 920                 925             
Lys
    


<210> 6449
<211> 932
<212> PRT
<213> Homo sapiens

<400> 6449
Met Ala Ala Pro Gln Ser Arg Pro Arg Arg Gly Glu Leu Ile Leu Leu
 1               5                  10                  15      
Cys Ala Leu Leu Gly Thr Leu Trp Glu Ile Gly Arg Gly Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Ser Lys Asp Leu Gly Leu Asp Pro Arg Lys Leu Ala Lys His Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ser Pro Arg Cys Leu Ile Asn Ile Asn Thr Leu Val Glu Asp
            100                 105                 110         
Lys Gly Lys Leu Phe Gly Val Glu Ile Glu Ile Ile Asp Ile Asn Asp
        115                 120                 125             
Asn Asn Pro Lys Phe Gln Val Glu Asp Leu Glu Val Lys Ile Asn Glu
    130                 135                 140                 
Ile Ala Val Pro Gly Ala Arg Tyr Pro Leu Pro Glu Ala Val Asp Pro
145                 150                 155                 160 
Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn His
                165                 170                 175     
His Phe Ser Leu Asp Val Gln Thr Gly Asp Asn Gly Ala Ile Asn Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Glu Glu Ala Ala His
        195                 200                 205             
His Leu Val Leu Thr Ala Ser Asp Gly Gly Lys Pro Pro Arg Ser Ser
    210                 215                 220                 
Thr Val Arg Ile His Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro
225                 230                 235                 240 
Val Phe Pro His Pro Ile Tyr Arg Val Lys Val Leu Glu Asn Met Pro
                245                 250                 255     
Pro Gly Thr Arg Leu Leu Thr Val Thr Ala Ser Asp Pro Asp Glu Gly
            260                 265                 270         
Ile Asn Gly Lys Val Ala Tyr Lys Phe Arg Lys Ile Asn Glu Lys Gln
        275                 280                 285             
Thr Pro Leu Phe Gln Leu Asn Glu Asn Thr Gly Glu Ile Ser Ile Ala
    290                 295                 300                 
Lys Ser Leu Asp Tyr Glu Glu Cys Ser Phe Tyr Glu Met Glu Ile Gln
305                 310                 315                 320 
Ala Glu Asp Val Gly Ala Leu Leu Gly Arg Thr Lys Leu Leu Ile Ser
                325                 330                 335     
Val Glu Asp Val Asn Asp Asn Arg Pro Glu Val Ile Ile Thr Ser Leu
            340                 345                 350         
Phe Ser Pro Val Leu Glu Asn Ser Leu Pro Gly Thr Val Ile Ala Phe
        355                 360                 365             
Leu Ser Val His Asp Gln Asp Ser Gly Lys Asn Gly Gln Val Val Cys
    370                 375                 380                 
Tyr Thr Arg Asp Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Gly Asn
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Arg Lys Tyr Leu Asp Arg Glu Asn Val Ser
                405                 410                 415     
Ile Tyr Asn Ile Thr Val Met Ala Ser Asp Leu Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Thr Gln Ile Ala Leu His Val Ala Asp Ile Asn Asp Asn
        435                 440                 445             
Pro Pro Thr Phe Pro His Ala Ser Tyr Ser Ala Tyr Ile Leu Glu Asn
    450                 455                 460                 
Asn Leu Arg Gly Ala Ser Ile Phe Ser Leu Thr Ala His Asp Pro Asp
465                 470                 475                 480 
Ser Gln Glu Asn Ala Gln Val Thr Tyr Ser Val Thr Glu Asp Thr Leu
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Tyr Ile Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Ile Arg Asp Leu
        515                 520                 525             
Gln Leu Leu Val Thr Ala Ser Asp Ser Gly Asp Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Met Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Arg Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val Leu
            660                 665                 670         
Thr Glu Leu Gly Ser Leu Lys Pro Ser Val Asp Pro Asn Asp Ser Ser
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Ile Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ala Val Leu Leu Gly Leu Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Asp Ser Gly Gly Arg Leu Val Gly Val Pro
                725                 730                 735     
Ala Ser His Phe Val Gly Val Glu Glu Val Gln Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser Gln Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Met Leu Ile Ser Gln Glu Gly
    770                 775                 780                 
Cys Glu Lys Asn Asp Ser Leu Leu Thr Ser Val Asp Phe His Glu Tyr
785                 790                 795                 800 
Lys Asn Glu Ala Asp His Gly Gln Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 6450
<211> 944
<212> PRT
<213> Homo sapiens

<400> 6450
Met Gly Pro Lys Thr Leu Pro Gln Leu Ala Gly Lys Trp Gln Val Leu
 1               5                  10                  15      
Cys Met Leu Ser Leu Cys Cys Trp Gly Trp Val Ser Gly Gln Leu Arg
            20                  25                  30          
Tyr Ser Val Val Glu Glu Ser Glu Pro Gly Thr Leu Val Gly Asn Val
        35                  40                  45              
Ala Gln Asp Leu Gly Leu Lys Met Thr Asp Leu Leu Ser Arg Arg Leu
    50                  55                  60                  
Gln Leu Gly Ser Glu Glu Asn Gly Arg Tyr Phe Ser Leu Ser Leu Met
65                  70                  75                  80  
Ser Gly Ala Leu Ala Val Asn Gln Lys Ile Asp Arg Glu Ser Leu Cys
                85                  90                  95      
Gly Ala Ser Thr Ser Cys Leu Leu Pro Val Gln Val Val Thr Glu His
            100                 105                 110         
Pro Leu Glu Leu Ile Arg Val Glu Val Glu Ile Leu Asp Leu Asn Asp
        115                 120                 125             
Asn Ser Pro Ser Phe Ala Thr Pro Glu Arg Glu Met Arg Ile Ser Glu
    130                 135                 140                 
Ser Ala Ala Ser Gly Ala Arg Phe Pro Leu Asp Ser Ala Gln Asp Pro
145                 150                 155                 160 
Asp Val Gly Thr Asn Thr Val Ser Phe Tyr Thr Leu Ser Pro Asn Ser
                165                 170                 175     
His Phe Ser Leu Asn Val Lys Thr Leu Lys Asp Gly Lys Pro Phe Pro
            180                 185                 190         
Glu Leu Val Leu Glu Gln Gln Leu Asp Arg Glu Ala Gln Ala Arg His
        195                 200                 205             
Gln Leu Val Leu Thr Ala Val Asp Gly Gly Thr Pro Ala Arg Ser Gly
    210                 215                 220                 
Thr Thr Leu Ile Ser Val Ile Val Leu Asp Ile Asn Asp Asn Ala Pro
225                 230                 235                 240 
Thr Phe Gln Ser Ser Val Leu Arg Val Gly Ile Pro Glu Asn Ala Pro
                245                 250                 255     
Ile Gly Thr Leu Leu Leu Arg Leu Asn Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Thr Asn Gly Gln Leu Asp Tyr Ser Phe Gly Asp His Thr Ser Glu Ala
        275                 280                 285             
Val Arg Asn Leu Phe Gly Leu Asp Pro Ser Ser Gly Ala Ile His Val
    290                 295                 300                 
Leu Gly Pro Ile Asp Phe Glu Glu Ser Arg Phe Tyr Glu Ile His Ala
305                 310                 315                 320 
Arg Ala Arg Asp Gln Gly Gln Pro Ala Met Glu Gly His Cys Val Ile
                325                 330                 335     
Gln Val Asp Val Gly Asp Val Asn Asp Asn Ala Pro Glu Val Leu Leu
            340                 345                 350         
Ala Ser Leu Ala Asn Pro Val Leu Glu Ser Thr Pro Val Gly Thr Val
        355                 360                 365             
Val Gly Leu Phe Asn Val Arg Asp Arg Asp Ser Gly Arg Asn Gly Glu
    370                 375                 380                 
Val Ser Leu Asp Ile Ser Pro Asp Leu Pro Phe Gln Ile Lys Pro Ser
385                 390                 395                 400 
Glu Asn His Tyr Ser Leu Leu Thr Ser Gln Pro Leu Asp Arg Glu Ala
                405                 410                 415     
Thr Ser His Tyr Ile Ile Glu Leu Leu Ala Ser Asp Ala Gly Ser Pro
            420                 425                 430         
Ser Leu His Lys His Leu Thr Ile Arg Leu Asn Ile Ser Asp Val Asn
        435                 440                 445             
Asp Asn Ala Pro Arg Phe Asn Gln Gln Leu Tyr Thr Ala Tyr Ile Leu
    450                 455                 460                 
Glu Asn Arg Pro Pro Gly Ser Leu Leu Cys Thr Val Ala Ala Ser Asp
465                 470                 475                 480 
Pro Asp Thr Gly Asp Asn Ala Arg Leu Thr Tyr Ser Ile Val Gly Asn
                485                 490                 495     
Gln Val Gln Gly Ala Pro Ala Ser Ser Phe Val Tyr Val Asn Pro Glu
            500                 505                 510         
Asp Gly Arg Ile Phe Ala Gln Arg Thr Phe Asp Tyr Glu Leu Leu Gln
        515                 520                 525             
Met Leu Gln Ile Val Val Gly Val Arg Asp Ser Gly Ser Pro Pro Leu
    530                 535                 540                 
His Ala Asn Thr Ser Leu His Val Phe Val Leu Asp Glu Asn Asp Asn
545                 550                 555                 560 
Ala Pro Ala Val Leu His Pro Arg Pro Asp Trp Glu His Ser Ala Pro
                565                 570                 575     
Gln Arg Leu Pro Arg Ser Ala Pro Pro Gly Ser Leu Val Thr Lys Val
            580                 585                 590         
Thr Ala Val Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr Ser
        595                 600                 605             
Leu Leu Pro Gln Ser Thr Ala Pro Gly Leu Phe Leu Val Ser Thr His
    610                 615                 620                 
Thr Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Glu Asp Asp Ser Asp
625                 630                 635                 640 
Thr Gln Gln Val Val Val Leu Val Arg Asp Asn Gly Asp Pro Ser Leu
                645                 650                 655     
Ser Ser Thr Ala Thr Val Leu Leu Val Leu Glu Asp Glu Asp Pro Glu
            660                 665                 670         
Glu Met Pro Lys Ser Ser Asp Phe Leu Ile His Pro Pro Glu Arg Ser
        675                 680                 685             
Asp Leu Thr Leu Tyr Leu Ile Val Ala Leu Ala Thr Val Ser Leu Leu
    690                 695                 700                 
Ser Leu Val Thr Phe Thr Phe Leu Ser Ala Lys Cys Leu Gln Gly Asn
705                 710                 715                 720 
Ala Asp Gly Asp Gly Gly Gly Gly Gln Cys Cys Arg Arg Gln Asp Ser
                725                 730                 735     
Pro Ser Pro Asp Phe Tyr Lys Gln Ser Ser Pro Asn Leu Gln Val Ser
            740                 745                 750         
Ser Asp Gly Thr Leu Lys Tyr Met Glu Val Thr Leu Arg Pro Thr Asp
        755                 760                 765             
Ser Gln Ser His Cys Tyr Arg Thr Cys Phe Ser Pro Ala Ser Asp Gly
    770                 775                 780                 
Ser Asp Phe Thr Phe Leu Arg Pro Leu Ser Val Gln Gln Pro Thr Ala
785                 790                 795                 800 
Leu Ala Leu Glu Pro Asp Ala Ile Arg Ser Arg Ser Asn Thr Leu Arg
                805                 810                 815     
Glu Arg Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln
            820                 825                 830         
Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly
        835                 840                 845             
Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile
    850                 855                 860                 
Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly
865                 870                 875                 880 
Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr
                885                 890                 895     
Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser
            900                 905                 910         
Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro
        915                 920                 925             
Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys
    930                 935                 940                 


<210> 6451
<211> 912
<212> PRT
<213> Homo sapiens

<400> 6451
Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu
 1               5                  10                  15      
Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly
            20                  25                  30          
Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp
        35                  40                  45              
Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly
    50                  55                  60                  
Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu
65                  70                  75                  80  
Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu
                85                  90                  95      
Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp
            100                 105                 110         
Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu
        115                 120                 125             
Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile
    130                 135                 140                 
Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser
145                 150                 155                 160 
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln
                165                 170                 175     
Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr
            180                 185                 190         
Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala
        195                 200                 205             
Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val
    210                 215                 220                 
Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln
225                 230                 235                 240 
Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile
                245                 250                 255     
Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu
            260                 265                 270         
Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp
        275                 280                 285             
Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly
    290                 295                 300                 
His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro
305                 310                 315                 320 
Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro
                325                 330                 335     
Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr
            340                 345                 350         
Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp
        355                 360                 365             
Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His
    370                 375                 380                 
Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr
385                 390                 395                 400 
Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met
                405                 410                 415     
Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val
            420                 425                 430         
Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys
        435                 440                 445             
Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr
    450                 455                 460                 
Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr
465                 470                 475                 480 
Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr
                485                 490                 495     
Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly
            500                 505                 510         
Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu
        515                 520                 525             
Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro
    530                 535                 540                 
Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys
545                 550                 555                 560 
Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile
                565                 570                 575     
Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu
            580                 585                 590         
Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr
        595                 600                 605             
Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu
    610                 615                 620                 
Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr
625                 630                 635                 640 
Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg
                645                 650                 655     
Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr
            660                 665                 670         
Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val
        675                 680                 685             
Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe
    690                 695                 700                 
Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val
705                 710                 715                 720 
Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp
                725                 730                 735     
Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser
            740                 745                 750         
Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr
        755                 760                 765             
Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala
    770                 775                 780                 
Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala
785                 790                 795                 800 
Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr
                805                 810                 815     
Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val
            820                 825                 830         
Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His
        835                 840                 845             
Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val
    850                 855                 860                 
Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg
865                 870                 875                 880 
Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro
                885                 890                 895     
Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile
            900                 905                 910         


<210> 6452
<211> 1220
<212> PRT
<213> Homo sapiens

<400> 6452
Met Pro Thr Thr Phe Pro Asp Ala Asp Phe Gln Asp Arg Pro Pro Ala
 1               5                  10                  15      
His Leu Val Ser Ser Arg Arg Ser Ala Pro Pro Gly Ser Arg Glu Pro
            20                  25                  30          
Arg Gly Thr Gly His Leu His Pro Pro Leu Gly Val Ser Gly Ser Ser
        35                  40                  45              
Trp Cys Leu Ala Cys Val Ser Trp Met Pro Cys Gly Phe Ser Pro Ser
    50                  55                  60                  
Pro Val Ala His His Leu Val Pro Gly Pro Pro Asp Thr Pro Ala Gln
65                  70                  75                  80  
Gln Leu Arg Ala Leu Thr Ser Ala Ala Ser Arg Cys Ser Thr His Ala
                85                  90                  95      
Ser Val Leu Leu Asp Val Ala Gly Glu Pro Ala Arg Cys Ile Leu Val
            100                 105                 110         
Leu Asn Gly Met Tyr Asp Thr Cys Ser Gly Ala Glu Ile Cys Lys Ala
        115                 120                 125             
Ala Gly Ile Asp Ser Leu Leu Leu Pro His Leu Glu Arg Ser Leu Thr
    130                 135                 140                 
Leu Leu Val Ser His Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pro
145                 150                 155                 160 
Ser Ser Glu Gln Gln Leu Cys Ala Leu Ser Lys His Pro Thr Val Ala
                165                 170                 175     
Phe Glu Asp Leu Gln Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Ala
            180                 185                 190         
Arg Asp Phe Ser Gln Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile
        195                 200                 205             
Val Gly Ala Arg Asn Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Ser
    210                 215                 220                 
Leu Leu Gln Ala Thr Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Ser
225                 230                 235                 240 
Cys Gln Ser Lys Gly Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Arg
                245                 250                 255     
Val Leu Ile Val Ala Gly Arg Lys Val Phe Met Cys Gly Thr Asn Ala
            260                 265                 270         
Phe Ser Pro Met Cys Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Thr
        275                 280                 285             
Ile Glu Lys Ile Asn Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg His
    290                 295                 300                 
Asn Ser Thr Ala Val Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Thr
305                 310                 315                 320 
Val Ile Asp Phe Ser Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gly
                325                 330                 335     
Ser Gly Pro Pro Leu Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu Asn
            340                 345                 350         
Glu Pro Asn Phe Val Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Phe
        355                 360                 365             
Phe Leu Arg Glu Asn Ala Val Glu His Asp Cys Gly Arg Thr Val Tyr
    370                 375                 380                 
Ser Arg Val Ala Arg Val Cys Lys Asn Asp Val Gly Gly Arg Phe Leu
385                 390                 395                 400 
Leu Glu Asp Thr Trp Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Ser
                405                 410                 415     
Arg Pro Gly Glu Val Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Phe
            420                 425                 430         
His Leu Pro Glu Gln Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Val
        435                 440                 445             
Asn Ser Ile Ala Ala Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Ile
    450                 455                 460                 
Ser Gln Ala Phe Asn Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Ala
465                 470                 475                 480 
Ala Trp Leu Pro Ile Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Thr
                485                 490                 495     
Leu Pro Glu Thr Gly Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gln
            500                 505                 510         
Asp Ala Gln Arg Leu Phe Leu Met Ser Glu Ala Val Gln Pro Val Thr
        515                 520                 525             
Pro Glu Pro Cys Val Thr Gln Asp Ser Val Arg Phe Ser His Leu Val
    530                 535                 540                 
Val Asp Leu Val Gln Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Ile
545                 550                 555                 560 
Gly Thr Glu Ser Gly Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Arg
                565                 570                 575     
Ser Leu His Gly Cys Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gly
            580                 585                 590         
Arg Arg Glu Pro Leu Arg Ser Leu Arg Ile Leu His Ser Ala Arg Ala
        595                 600                 605             
Leu Phe Val Gly Leu Arg Asp Gly Val Leu Arg Val Pro Leu Glu Arg
    610                 615                 620                 
Cys Ala Ala Tyr Arg Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pro
625                 630                 635                 640 
Tyr Cys Gly Trp Asp Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu Asp
                645                 650                 655     
Ser Ser Asn Met Ser Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Val
            660                 665                 670         
Arg Asn Val Thr Arg Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gln
        675                 680                 685             
Pro Cys Glu His Leu Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Arg
    690                 695                 700                 
Ala Arg Ser Cys Asp Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cys
705                 710                 715                 720 
Leu Gly Pro Ala Ile His Ile Ala Asn Cys Ser Arg Asn Gly Ala Trp
                725                 730                 735     
Thr Pro Trp Ser Ser Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gly
            740                 745                 750         
Phe Gln Val Arg Gln Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gly
        755                 760                 765             
Gly Arg Ile Cys Val Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Glu
    770                 775                 780                 
Asn Thr Pro Cys Pro Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Trp
785                 790                 795                 800 
Ser Lys Cys Ser Ser Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Arg
                805                 810                 815     
Ala Cys Glu Asn Gly Asn Ser Cys Leu Gly Cys Gly Val Glu Phe Lys
            820                 825                 830         
Thr Cys Asn Pro Glu Gly Cys Pro Glu Val Arg Arg Asn Thr Pro Trp
        835                 840                 845             
Thr Pro Trp Leu Pro Val Asn Val Thr Gln Gly Gly Ala Arg Gln Glu
    850                 855                 860                 
Gln Arg Phe Arg Phe Thr Cys Arg Ala Pro Leu Ala Asp Pro His Gly
865                 870                 875                 880 
Leu Gln Phe Gly Arg Arg Arg Thr Glu Thr Arg Thr Cys Pro Ala Asp
                885                 890                 895     
Gly Ser Gly Ser Cys Asp Thr Asp Ala Leu Val Glu Val Leu Leu Arg
            900                 905                 910         
Ser Gly Ser Thr Ser Pro His Thr Val Ser Gly Gly Trp Ala Ala Trp
        915                 920                 925             
Gly Pro Trp Ser Ser Cys Ser Arg Asp Cys Glu Leu Gly Phe Arg Val
    930                 935                 940                 
Arg Lys Arg Thr Cys Thr Asn Pro Glu Pro Arg Asn Gly Gly Leu Pro
945                 950                 955                 960 
Cys Val Gly Asp Ala Ala Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cys
                965                 970                 975     
Pro Val Arg Gly Ala Trp Ser Cys Trp Thr Ser Trp Ser Pro Cys Ser
            980                 985                 990         
Ala Ser Cys Gly Gly Gly His Tyr Gln Arg Thr Arg Ser Cys Thr Ser
        995                 1000                1005            
Pro Ala Pro Ser Pro Gly Glu Asp Ile Cys Leu Gly Leu His Thr Glu
    1010                1015                1020                
Glu Ala Leu Cys Ala Thr Gln Ala Cys Pro Glu Gly Trp Ser Pro Trp
1025                1030                1035                1040
Ser Glu Trp Ser Lys Cys Thr Asp Asp Gly Ala Gln Ser Arg Ser Arg
                1045                1050                1055    
His Cys Glu Glu Leu Leu Pro Gly Ser Ser Ala Cys Ala Gly Asn Ser
            1060                1065                1070        
Ser Gln Ser Arg Pro Cys Pro Tyr Ser Glu Ile Pro Val Ile Leu Pro
        1075                1080                1085            
Ala Ser Ser Met Glu Glu Ala Thr Asp Cys Ala Gly Phe Asn Leu Ile
    1090                1095                1100                
His Leu Val Ala Thr Gly Ile Ser Cys Phe Leu Gly Ser Gly Leu Leu
1105                1110                1115                1120
Thr Leu Ala Val Tyr Leu Ser Cys Gln His Cys Gln Arg Gln Ser Gln
                1125                1130                1135    
Glu Ser Thr Leu Val His Pro Ala Thr Pro Asn His Leu His Tyr Lys
            1140                1145                1150        
Gly Gly Gly Thr Pro Lys Asn Glu Lys Tyr Thr Pro Met Glu Phe Lys
        1155                1160                1165            
Thr Leu Asn Lys Asn Asn Leu Ile Pro Asp Asp Arg Ala Asn Phe Tyr
    1170                1175                1180                
Pro Leu Gln Gln Thr Asn Val Tyr Thr Thr Thr Tyr Tyr Pro Ser Pro
1185                1190                1195                1200
Leu Asn Lys His Ser Phe Arg Pro Glu Ala Ser Pro Gly Gln Arg Cys
                1205                1210                1215    
Phe Pro Asn Ser
            1220


<210> 6453
<211> 1092
<212> PRT
<213> Homo sapiens

<400> 6453
Met Pro Cys Gly Phe Ser Pro Ser Pro Val Ala His His Leu Val Pro
 1               5                  10                  15      
Gly Pro Pro Asp Thr Pro Ala Gln Gln Leu Arg Cys Gly Trp Thr Val
            20                  25                  30          
Gly Gly Trp Leu Leu Ser Leu Val Arg Gly Leu Leu Pro Cys Leu Pro
        35                  40                  45              
Pro Gly Ala Arg Thr Ala Glu Gly Pro Ile Met Val Leu Ala Gly Pro
    50                  55                  60                  
Leu Ala Val Ser Leu Leu Leu Pro Ser Leu Thr Leu Leu Val Ser His
65                  70                  75                  80  
Leu Ser Ser Ser Gln Asp Val Ser Ser Glu Pro Ser Ser Glu Gln Gln
                85                  90                  95      
Leu Cys Ala Leu Ser Lys His Pro Thr Val Ala Phe Glu Asp Leu Gln
            100                 105                 110         
Pro Trp Val Ser Asn Phe Thr Tyr Pro Gly Ala Arg Asp Phe Ser Gln
        115                 120                 125             
Leu Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile Val Gly Ala Arg Asn
    130                 135                 140                 
Tyr Leu Phe Arg Leu Ser Leu Ala Asn Val Ser Leu Leu Gln Ala Thr
145                 150                 155                 160 
Glu Trp Ala Ser Ser Glu Asp Thr Arg Arg Ser Cys Gln Ser Lys Gly
                165                 170                 175     
Lys Thr Glu Glu Glu Cys Gln Asn Tyr Val Arg Val Leu Ile Val Ala
            180                 185                 190         
Gly Arg Lys Val Phe Met Cys Gly Thr Asn Ala Phe Ser Pro Met Cys
        195                 200                 205             
Thr Ser Arg Gln Val Gly Asn Leu Ser Arg Thr Ile Glu Lys Ile Asn
    210                 215                 220                 
Gly Val Ala Arg Cys Pro Tyr Asp Pro Arg His Asn Ser Thr Ala Val
225                 230                 235                 240 
Ile Ser Ser Gln Gly Glu Leu Tyr Ala Ala Thr Val Ile Asp Phe Ser
                245                 250                 255     
Gly Arg Asp Pro Ala Ile Tyr Arg Ser Leu Gly Ser Gly Pro Pro Leu
            260                 265                 270         
Arg Thr Ala Gln Tyr Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Val
        275                 280                 285             
Ala Ala Tyr Asp Ile Gly Leu Phe Ala Tyr Phe Phe Leu Arg Glu Asn
    290                 295                 300                 
Ala Val Glu His Asp Cys Gly Arg Thr Val Tyr Ser Arg Val Ala Arg
305                 310                 315                 320 
Val Cys Lys Asn Asp Val Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp
                325                 330                 335     
Thr Thr Phe Met Lys Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Val
            340                 345                 350         
Pro Phe Tyr Tyr Asn Glu Leu Gln Ser Ala Phe His Leu Pro Glu Gln
        355                 360                 365             
Asp Leu Ile Tyr Gly Val Phe Thr Thr Asn Val Asn Ser Ile Ala Ala
    370                 375                 380                 
Ser Ala Val Cys Ala Phe Asn Leu Ser Ala Ile Ser Gln Ala Phe Asn
385                 390                 395                 400 
Gly Pro Phe Arg Tyr Gln Glu Asn Pro Arg Ala Ala Trp Leu Pro Ile
                405                 410                 415     
Ala Asn Pro Ile Pro Asn Phe Gln Cys Gly Thr Leu Pro Glu Thr Gly
            420                 425                 430         
Pro Asn Glu Asn Leu Thr Glu Arg Ser Leu Gln Asp Ala Gln Arg Leu
        435                 440                 445             
Phe Leu Met Ser Glu Ala Val Gln Pro Val Thr Pro Glu Pro Cys Val
    450                 455                 460                 
Thr Gln Asp Ser Val Arg Phe Ser His Leu Val Val Asp Leu Val Gln
465                 470                 475                 480 
Ala Lys Asp Thr Leu Tyr His Val Leu Tyr Ile Gly Thr Glu Ser Gly
                485                 490                 495     
Thr Ile Leu Lys Ala Leu Ser Thr Ala Ser Arg Ser Leu His Gly Cys
            500                 505                 510         
Tyr Leu Glu Glu Leu His Val Leu Pro Pro Gly Arg Arg Glu Pro Leu
        515                 520                 525             
Arg Ser Leu Arg Ile Leu His Ser Ala Arg Ala Leu Phe Val Gly Leu
    530                 535                 540                 
Arg Asp Gly Val Leu Arg Val Pro Leu Glu Arg Cys Ala Ala Tyr Arg
545                 550                 555                 560 
Ser Gln Gly Ala Cys Leu Gly Ala Arg Asp Pro Tyr Cys Gly Trp Asp
                565                 570                 575     
Gly Lys Gln Gln Arg Cys Ser Thr Leu Glu Asp Ser Ser Asn Met Ser
            580                 585                 590         
Leu Trp Thr Gln Asn Ile Thr Ala Cys Pro Val Arg Asn Val Thr Arg
        595                 600                 605             
Asp Gly Gly Phe Gly Pro Trp Ser Pro Trp Gln Pro Cys Glu His Leu
    610                 615                 620                 
Asp Gly Asp Asn Ser Gly Ser Cys Leu Cys Arg Ala Arg Ser Cys Asp
625                 630                 635                 640 
Ser Pro Arg Pro Arg Cys Gly Gly Leu Asp Cys Leu Gly Pro Ala Ile
                645                 650                 655     
His Ile Ala Asn Cys Ser Arg Asn Gly Ala Trp Thr Pro Trp Ser Ser
            660                 665                 670         
Trp Ala Leu Cys Ser Thr Ser Cys Gly Ile Gly Phe Gln Val Arg Gln
        675                 680                 685             
Arg Ser Cys Ser Asn Pro Ala Pro Arg His Gly Gly Arg Ile Phe Val
    690                 695                 700                 
Gly Lys Ser Arg Glu Glu Arg Phe Cys Asn Glu Asn Thr Pro Cys Pro
705                 710                 715                 720 
Val Pro Ile Phe Trp Ala Ser Trp Gly Ser Trp Ser Lys Cys Ser Ser
                725                 730                 735     
Asn Cys Gly Gly Gly Met Gln Ser Arg Arg Arg Ala Cys Glu Asn Gly
            740                 745                 750         
Asn Ser Cys Leu Gly Cys Gly Glu Phe Lys Thr Cys Asn Pro Glu Gly
        755                 760                 765             
Cys Pro Glu Val Arg Arg Asn Thr Pro Trp Thr Pro Trp Leu Pro Val
    770                 775                 780                 
Asn Val Thr Gln Gly Gly Ala Arg Gln Glu Gln Arg Phe Arg Phe Thr
785                 790                 795                 800 
Cys Arg Ala Pro Leu Ala Asp Pro His Gly Leu Gln Phe Gly Arg Arg
                805                 810                 815     
Arg Thr Glu Thr Arg Thr Cys Pro Ala Asp Gly Ser Gly Ser Cys Asp
            820                 825                 830         
Thr Asp Ala Leu Val Glu Val Leu Leu Arg Ser Gly Ser Thr Ser Pro
        835                 840                 845             
His Thr Val Ser Gly Gly Trp Ala Ala Trp Gly Pro Trp Ser Ser Cys
    850                 855                 860                 
Ser Arg Asp Cys Glu Leu Gly Phe Arg Val Arg Lys Arg Thr Cys Thr
865                 870                 875                 880 
Asn Pro Glu Pro Arg Asn Gly Gly Leu Pro Cys Val Gly Asp Ala Ala
                885                 890                 895     
Glu Tyr Gln Asp Cys Asn Pro Gln Ala Cys Pro Val Arg Gly Ala Trp
            900                 905                 910         
Ser Cys Trp Thr Ser Trp Ser Pro Cys Ser Ala Ser Cys Gly Gly Gly
        915                 920                 925             
His Tyr Gln Arg Thr Arg Ser Cys Thr Ser Pro Ala Pro Ser Pro Gly
    930                 935                 940                 
Glu Asp Ile Cys Leu Gly Leu His Thr Glu Glu Ala Leu Cys Ala Thr
945                 950                 955                 960 
Gln Ala Cys Pro Gly Trp Ser Pro Trp Ser Glu Trp Ser Lys Cys Thr
                965                 970                 975     
Asp Asp Gly Ala Gln Ser Arg Ser Arg His Cys Glu Glu Leu Leu Pro
            980                 985                 990         
Gly Ser Ser Ala Cys Ala Gly Asn Ser Ser Gln Ser Arg Pro Cys Pro
        995                 1000                1005            
Tyr Ser Glu Ile Pro Val Ile Leu Pro Ala Ser Ser Met Glu Glu Ala
    1010                1015                1020                
Thr Asp Cys Ala Gly Lys Arg Asn Arg Thr Tyr Leu Met Leu Arg Ser
1025                1030                1035                1040
Ser Gln Pro Ser Ser Thr Pro Leu Gln Ser Leu Asp Ser Phe His Ile
                1045                1050                1055    
Leu Leu Gln Thr Ala Lys Leu Cys Trp Gly Pro His Cys Phe Glu Met
            1060                1065                1070        
Gly Ser Ile Ser Ser Thr Trp Trp Pro Arg Ala Ser Pro Ala Ser Trp
        1075                1080                1085            
Ala Leu Gly Ser
    1090        


<210> 6454
<211> 266
<212> PRT
<213> Homo sapiens

<400> 6454
Met Pro Ile Trp Val Val Leu Leu Ser Arg Ile Ile Met Lys Glu Lys
 1               5                  10                  15      
Gln Ser Thr Lys Val Tyr Leu Ser Leu Ile Pro Ile Ile Ser Gly Val
            20                  25                  30          
Leu Leu Ala Thr Val Thr Glu Leu Ser Phe Asp Met Trp Gly Leu Val
        35                  40                  45              
Ser Ala Leu Ala Ala Thr Leu Cys Phe Ser Leu Gln Asn Ile Phe Ser
    50                  55                  60                  
Lys Lys Val Leu Arg Asp Ser Arg Ile His His Leu Arg Leu Leu Asn
65                  70                  75                  80  
Ile Leu Gly Cys His Ala Val Phe Phe Met Ile Pro Thr Trp Val Leu
                85                  90                  95      
Val Asp Leu Ser Ala Phe Leu Val Ser Ser Asp Leu Thr Tyr Val Tyr
            100                 105                 110         
Gln Trp Pro Trp Thr Leu Leu Leu Leu Ala Val Ser Gly Phe Cys Asn
        115                 120                 125             
Phe Ala Gln Asn Val Ile Ala Phe Ser Ile Leu Asn Leu Val Ser Pro
    130                 135                 140                 
Leu Ser Tyr Ser Val Ala Asn Ala Thr Lys Arg Ile Met Val Ile Thr
145                 150                 155                 160 
Val Ser Leu Ile Met Leu Arg Asn Pro Val Thr Ser Thr Asn Val Leu
                165                 170                 175     
Gly Met Met Thr Ala Ile Leu Gly Val Phe Leu Tyr Asn Lys Thr Lys
            180                 185                 190         
Tyr Asp Ala Asn Gln Gln Ala Arg Lys His Leu Leu Pro Val Thr Thr
        195                 200                 205             
Ala Asp Leu Ser Ser Lys Glu Arg His Arg Ser Pro Leu Glu Lys Pro
    210                 215                 220                 
His Asn Gly Leu Leu Phe Pro Gln His Gly Asp Tyr Gln Tyr Gly Arg
225                 230                 235                 240 
Asn Asn Ile Leu Thr Asp His Phe Gln Tyr Ser Arg Gln Ser Tyr Pro
                245                 250                 255     
Asn Ser Tyr Ser Leu Asn Arg Tyr Asp Val
            260                 265     


<210> 6455
<211> 423
<212> PRT
<213> Homo sapiens

<400> 6455
Met Pro Ile Thr Cys Pro Thr Gln Asn Glu Pro Phe Leu Arg Thr Pro
 1               5                  10                  15      
Arg Asn Ser Asn Tyr Thr Tyr Pro Ile Lys Pro Ala Ile Glu Asn Trp
            20                  25                  30          
Gly Ser Asp Phe Leu Cys Thr Glu Trp Lys Ala Ser Asn Ser Val Pro
        35                  40                  45              
Thr Ser Val His Gln Leu Arg Pro Ala Asp Ile Lys Val Val Ala Ala
    50                  55                  60                  
Leu Gly Asp Ser Leu Thr Thr Ala Val Gly Ala Arg Pro Asn Asn Ser
65                  70                  75                  80  
Ser Asp Leu Pro Thr Ser Trp Arg Gly Leu Ser Trp Ser Ile Gly Gly
                85                  90                  95      
Asp Gly Asn Leu Glu Thr His Thr Thr Leu Pro Asn Ile Leu Lys Lys
            100                 105                 110         
Phe Asn Pro Tyr Leu Leu Gly Phe Ser Thr Ser Thr Trp Glu Gly Thr
        115                 120                 125             
Ala Gly Leu Asn Val Ala Ala Glu Gly Ala Arg Ala Arg Asp Met Pro
    130                 135                 140                 
Ala Gln Ala Trp Asp Leu Leu Glu Arg Met Lys Asn Ser Pro Asp Ile
145                 150                 155                 160 
Asn Leu Glu Lys Asp Trp Lys Leu Val Thr Leu Phe Ile Gly Val Asn
                165                 170                 175     
Asp Leu Cys His Tyr Cys Glu Asn Pro Glu Ala His Leu Ala Thr Glu
            180                 185                 190         
Tyr Val Gln His Ile Gln Gln Ala Leu Asp Ile Leu Ser Glu Glu Leu
        195                 200                 205             
Pro Arg Ala Phe Val Asn Val Val Glu Val Met Glu Leu Ala Ser Leu
    210                 215                 220                 
Tyr Gln Gly Gln Gly Gly Lys Cys Ala Met Leu Ala Ala Gln Asn Asn
225                 230                 235                 240 
Cys Thr Cys Leu Arg His Ser Gln Ser Ser Leu Glu Lys Gln Glu Leu
                245                 250                 255     
Lys Lys Val Asn Trp Asn Leu Gln His Gly Ile Ser Ser Phe Ser Tyr
            260                 265                 270         
Trp His Gln Tyr Thr Gln Arg Glu Asp Phe Ala Val Val Val Gln Pro
        275                 280                 285             
Phe Phe Gln Asn Thr Leu Thr Pro Leu Asn Glu Arg Gly Asp Thr Asp
    290                 295                 300                 
Leu Thr Phe Phe Ser Glu Asp Cys Phe His Phe Ser Asp Arg Gly His
305                 310                 315                 320 
Ala Glu Met Ala Ile Ala Leu Trp Asn Asn Met Leu Glu Pro Val Gly
                325                 330                 335     
Arg Lys Thr Thr Ser Asn Asn Phe Thr His Ser Arg Ala Lys Leu Lys
            340                 345                 350         
Cys Pro Ser Pro Glu Ser Pro Tyr Leu Tyr Thr Leu Arg Asn Ser Arg
        355                 360                 365             
Leu Leu Pro Asp Gln Ala Glu Glu Ala Pro Glu Val Leu Tyr Trp Ala
    370                 375                 380                 
Val Pro Val Ala Ala Gly Val Gly Leu Val Val Gly Ile Ile Gly Thr
385                 390                 395                 400 
Val Val Trp Arg Cys Arg Arg Gly Gly Arg Arg Glu Asp Pro Pro Met
                405                 410                 415     
Ser Leu Arg Thr Val Ala Leu
            420             


<210> 6456
<211> 1841
<212> PRT
<213> Homo sapiens

<400> 6456
Met Phe Gln Cys Phe Ala Arg Asn Ala Ala Gly Glu Val Gln Thr Ser
 1               5                  10                  15      
Thr Tyr Leu Ala Val Thr Ser Ile Ala Pro Asn Ile Thr Arg Gly Pro
            20                  25                  30          
Leu Asp Ser Thr Val Ile Asp Gly Met Ser Val Val Leu Ala Cys Glu
        35                  40                  45              
Thr Ser Gly Ala Pro Arg Pro Ala Ile Thr Trp Gln Lys Gly Glu Arg
    50                  55                  60                  
Ile Leu Ala Ser Gly Ser Val Gln Leu Pro Arg Phe Thr Pro Leu Glu
65                  70                  75                  80  
Ser Gly Ser Leu Leu Ile Ser Pro Thr His Ile Ser Asp Ala Gly Thr
                85                  90                  95      
Tyr Thr Cys Leu Ala Thr Asn Ser Arg Gly Val Asp Glu Ala Ser Ala
            100                 105                 110         
Asp Leu Val Val Trp Ala Arg Thr Arg Ile Thr Lys Pro Pro Gln Asp
        115                 120                 125             
Gln Ser Val Ile Lys Gly Thr Gln Ala Ser Met Val Cys Gly Val Thr
    130                 135                 140                 
His Asp Pro Arg Val Thr Ile Arg Tyr Ile Trp Glu Lys Asp Gly Ala
145                 150                 155                 160 
Thr Leu Gly Thr Glu Ser His Pro Arg Ile Arg Leu Asp Arg Asn Gly
                165                 170                 175     
Ser Leu His Ile Ser Gln Thr Trp Ser Gly Asp Ile Gly Thr Tyr Thr
            180                 185                 190         
Cys Arg Val Ile Ser Ala Gly Gly Asn Asp Ser Arg Ser Ala His Leu
        195                 200                 205             
Arg Val Arg Gln Leu Pro His Ala Pro Glu His Pro Val Ala Thr Leu
    210                 215                 220                 
Ser Thr Val Glu Arg Arg Ala Ile Asn Leu Thr Trp Thr Lys Pro Phe
225                 230                 235                 240 
Asp Gly Asn Ser Pro Leu Ile Arg Tyr Ile Leu Glu Met Ser Glu Asn
                245                 250                 255     
Asn Ala Pro Trp Thr Val Leu Leu Ala Ser Val Asp Pro Lys Ala Thr
            260                 265                 270         
Ser Val Thr Val Lys Gly Leu Val Pro Ala Arg Ser Tyr Gln Phe Arg
        275                 280                 285             
Leu Cys Ala Val Asn Asp Val Gly Lys Gly Gln Phe Ser Lys Asp Thr
    290                 295                 300                 
Glu Arg Val Ser Leu Pro Glu Glu Pro Pro Thr Ala Pro Pro Gln Asn
305                 310                 315                 320 
Val Ile Ala Ser Gly Arg Thr Asn Gln Ser Ile Met Ile Gln Trp Gln
                325                 330                 335     
Pro Pro Pro Glu Ser His Gln Asn Gly Ile Leu Lys Gly Tyr Ile Ile
            340                 345                 350         
Arg Tyr Cys Leu Ala Gly Leu Pro Val Gly Tyr Gln Phe Lys Asn Ile
        355                 360                 365             
Thr Asp Ala Asp Val Asn Asn Leu Leu Leu Glu Asp Leu Ile Ile Trp
    370                 375                 380                 
Thr Asn Tyr Glu Ile Glu Val Ala Ala Tyr Asn Ser Ala Gly Leu Gly
385                 390                 395                 400 
Val Tyr Ser Ser Lys Val Thr Glu Trp Thr Leu Gln Gly Val Pro Thr
                405                 410                 415     
Val Pro Pro Gly Asn Val His Ala Glu Ala Thr Asn Ser Thr Thr Ile
            420                 425                 430         
Arg Phe Thr Trp Asn Ala Pro Ser Pro Gln Phe Ile Asn Gly Ile Asn
        435                 440                 445             
Gln Gly Tyr Lys Leu Ile Ala Trp Glu Pro Glu Gln Glu Glu Glu Val
    450                 455                 460                 
Thr Met Val Thr Ala Arg Pro Asn Phe Gln Asp Ser Ile His Val Gly
465                 470                 475                 480 
Phe Val Ser Gly Leu Lys Lys Phe Thr Glu Tyr Phe Thr Ser Val Leu
                485                 490                 495     
Cys Phe Thr Thr Pro Gly Asp Gly Pro Arg Ser Thr Pro Gln Leu Val
            500                 505                 510         
Arg Thr His Glu Asp Val Pro Gly Pro Val Gly His Leu Ser Phe Ser
        515                 520                 525             
Glu Ile Leu Asp Thr Ser Leu Lys Val Ser Trp Gln Glu Pro Gly Glu
    530                 535                 540                 
Lys Asn Gly Ile Leu Thr Gly Tyr Arg Ile Ser Trp Glu Glu Tyr Asn
545                 550                 555                 560 
Arg Thr Asn Thr Arg Val Thr His Tyr Leu Pro Asn Val Thr Leu Glu
                565                 570                 575     
Tyr Arg Val Thr Gly Leu Thr Ala Leu Thr Thr Tyr Thr Ile Glu Val
            580                 585                 590         
Ala Ala Met Thr Ser Lys Gly Gln Gly Gln Val Ser Ala Ser Thr Ile
        595                 600                 605             
Ser Ser Gly Val Pro Pro Glu Leu Pro Gly Pro Pro Thr Asn Leu Gly
    610                 615                 620                 
Ile Ser Asn Ile Gly Pro Arg Ser Val Thr Leu Gln Phe Arg Pro Gly
625                 630                 635                 640 
Tyr Asp Gly Lys Thr Ser Ile Ser Arg Trp Leu Val Glu Ala Gln Val
                645                 650                 655     
Gly Val Val Gly Glu Gly Glu Glu Trp Leu Leu Ile His Gln Leu Ser
            660                 665                 670         
Asn Glu Pro Asp Ala Arg Ser Met Glu Val Pro Asp Leu Asn Pro Phe
        675                 680                 685             
Thr Cys Tyr Ser Phe Arg Met Arg Gln Val Asn Ile Val Gly Thr Ser
    690                 695                 700                 
Pro Pro Ser Gln Pro Ser Arg Lys Ile Gln Thr Leu Gln Ala Pro Pro
705                 710                 715                 720 
Asp Met Ala Pro Ala Asn Val Ser Leu Arg Thr Ala Ser Glu Thr Ser
                725                 730                 735     
Leu Trp Leu Arg Trp Met Pro Leu Pro Glu Met Glu Tyr Asn Gly Asn
            740                 745                 750         
Pro Glu Ser Val Gly Tyr Lys Ile Lys Tyr Ser Arg Ser Asp Gly His
        755                 760                 765             
Gly Lys Thr Leu Ser His Val Val Gln Asp Arg Val Glu Arg Asp Tyr
    770                 775                 780                 
Thr Ile Glu Asp Leu Glu Glu Trp Thr Glu Tyr Arg Val Gln Val Gln
785                 790                 795                 800 
Ala Phe Asn Ala Ile Gly Ser Gly Pro Trp Ser Gln Thr Val Val Gly
                805                 810                 815     
Arg Thr Arg Glu Ser Val Pro Ser Ser Gly Pro Thr Asn Val Ser Ala
            820                 825                 830         
Leu Ala Thr Thr Ser Ser Ser Met Leu Val Arg Trp Ser Glu Val Pro
        835                 840                 845             
Glu Ala Asp Arg Asn Gly Leu Val Leu Gly Tyr Lys Val Met Tyr Lys
    850                 855                 860                 
Glu Lys Asp Ser Asp Thr Gln Pro Arg Phe Trp Leu Val Glu Gly Asn
865                 870                 875                 880 
Ser Ser Arg Ser Ala Gln Leu Thr Gly Leu Gly Lys Tyr Val Leu Tyr
                885                 890                 895     
Glu Val Gln Val Leu Ala Phe Thr Arg Ile Gly Asp Gly Ser Pro Ser
            900                 905                 910         
His Pro Pro Ile Leu Glu Arg Thr Leu Asp Asp Val Pro Gly Pro Pro
        915                 920                 925             
Met Gly Ile Leu Phe Pro Glu Val Arg Thr Thr Ser Val Arg Leu Ile
    930                 935                 940                 
Trp Gln Pro Pro Ala Ala Pro Asn Gly Ile Ile Leu Ala Tyr Gln Ile
945                 950                 955                 960 
Thr His Arg Leu Asn Thr Thr Thr Ala Asn Thr Ala Thr Val Glu Val
                965                 970                 975     
Leu Ala Pro Ser Ala Arg Gln Tyr Thr Ala Thr Gly Leu Lys Pro Glu
            980                 985                 990         
Ser Val Tyr Leu Phe Arg Ile Thr Ala Gln Thr Arg Lys Gly Trp Gly
        995                 1000                1005            
Glu Ala Ala Glu Ala Leu Val Val Thr Thr Glu Lys Arg Asp Arg Pro
    1010                1015                1020                
Gln Pro Pro Ser Arg Pro Met Val Gln Gln Glu Asp Val Arg Ala Arg
1025                1030                1035                1040
Ser Val Leu Leu Ser Trp Glu Pro Gly Ser Asp Gly Leu Ser Pro Val
                1045                1050                1055    
Arg Tyr Tyr Thr Ile Gln Thr Arg Glu Leu Pro Ser Gly Arg Trp Ala
            1060                1065                1070        
Leu His Ser Ala Ser Val Ser His Asn Ala Ser Ser Phe Ile Val Asp
        1075                1080                1085            
Arg Leu Lys Pro Phe Thr Ser Tyr Lys Phe Arg Val Lys Ala Thr Asn
    1090                1095                1100                
Asp Ile Gly Asp Ser Glu Phe Ser Glu Glu Ser Glu Ser Leu Thr Thr
1105                1110                1115                1120
Leu Gln Ala Ala Pro Asp Glu Ala Pro Thr Ile Leu Ser Val Thr Pro
                1125                1130                1135    
His Thr Thr Thr Ser Val Leu Ile Arg Trp Gln Pro Pro Ala Glu Asp
            1140                1145                1150        
Lys Ile Asn Gly Ile Leu Leu Gly Phe Arg Ile Arg Tyr Arg Glu Leu
        1155                1160                1165            
Leu Tyr Glu Gly Leu Arg Gly Phe Thr Leu Arg Gly Ile Asn Asn Pro
    1170                1175                1180                
Gly Ala Thr Trp Ala Glu Leu Thr Ser Met Tyr Ser Met Arg Asn Leu
1185                1190                1195                1200
Ser Arg Pro Ser Leu Thr Gln Tyr Glu Leu Asp Asn Leu Asn Lys His
                1205                1210                1215    
Arg Arg Tyr Glu Ile Arg Met Ser Val Tyr Asn Ala Val Gly Glu Gly
            1220                1225                1230        
Pro Ser Ser Pro Pro Gln Glu Val Phe Val Gly Glu Ala Val Pro Thr
        1235                1240                1245            
Ala Ala Pro Arg Asn Val Val Val His Gly Ala Thr Ala Thr Gln Leu
    1250                1255                1260                
Asp Val Thr Trp Glu Pro Pro Pro Leu Asp Ser Gln Asn Gly Asp Ile
1265                1270                1275                1280
Gln Gly Tyr Lys Ile Tyr Phe Trp Glu Ala Gln Arg Gly Asn Leu Thr
                1285                1290                1295    
Glu Arg Val Lys Thr Leu Phe Leu Ala Glu Asn Ser Val Lys Leu Lys
            1300                1305                1310        
Asn Leu Thr Gly Tyr Thr Ala Tyr Met Val Ser Val Ala Ala Phe Asn
        1315                1320                1325            
Ala Ala Gly Asp Gly Pro Arg Ser Thr Pro Thr Gln Gly Gln Thr Gln
    1330                1335                1340                
Gln Ala Ala Pro Ser Ala Pro Ser Ser Val Lys Phe Ser Glu Leu Thr
1345                1350                1355                1360
Thr Thr Ser Val Asn Val Ser Trp Glu Ala Pro Gln Phe Pro Asn Gly
                1365                1370                1375    
Ile Leu Glu Gly Tyr Arg Leu Val Tyr Glu Pro Cys Ser Pro Val Asp
            1380                1385                1390        
Gly Val Ser Lys Ile Val Thr Val Asp Val Lys Gly Asn Ser Pro Leu
        1395                1400                1405            
Trp Leu Lys Val Lys Asp Leu Ala Glu Gly Val Thr Tyr Arg Phe Arg
    1410                1415                1420                
Ile Arg Ala Lys Thr Phe Thr Tyr Gly Pro Glu Ile Glu Ala Asn Val
1425                1430                1435                1440
Thr Thr Gly Pro Gly Glu Gly Ala Pro Gly Pro Pro Gly Val Pro Ile
                1445                1450                1455    
Ile Val Arg Tyr Ser Ser Ala Ile Ala Ile His Trp Ser Ser Gly Asp
            1460                1465                1470        
Pro Gly Lys Gly Pro Ile Thr Arg Tyr Val Ile Glu Ala Arg Pro Ser
        1475                1480                1485            
Asp Glu Gly Leu Trp Asp Ile Leu Ile Lys Asp Ile Pro Lys Glu Val
    1490                1495                1500                
Ser Ser Tyr Thr Phe Ser Met Asp Ile Leu Lys Pro Gly Val Ser Tyr
1505                1510                1515                1520
Asp Phe Arg Val Ile Ala Val Asn Asp Tyr Gly Phe Gly Thr Pro Ser
                1525                1530                1535    
Ser Pro Ser Gln Ser Val Pro Ala Gln Lys Ala Asn Pro Phe Tyr Glu
            1540                1545                1550        
Glu Trp Trp Phe Leu Val Val Ile Ala Leu Val Gly Leu Ile Phe Ile
        1555                1560                1565            
Leu Leu Leu Val Phe Val Leu Ile Ile Arg Gly Gln Ser Lys Lys Tyr
    1570                1575                1580                
Ala Lys Lys Thr Asp Ser Gly Asn Ser Ala Lys Ser Gly Ala Leu Gly
1585                1590                1595                1600
His Ser Glu Met Met Ser Leu Asp Glu Ser Ser Phe Pro Ala Leu Glu
                1605                1610                1615    
Leu Asn Asn Arg Arg Leu Ser Val Lys Asn Ser Phe Cys Arg Lys Asn
            1620                1625                1630        
Gly Leu Tyr Thr Arg Ser Pro Pro Arg Pro Ser Pro Gly Ser Leu His
        1635                1640                1645            
Tyr Ser Asp Glu Asp Val Thr Lys Tyr Asn Asp Leu Ile Pro Ala Glu
    1650                1655                1660                
Ser Ser Ser Leu Thr Glu Lys Pro Ser Glu Ile Ser Asp Ser Gln Gly
1665                1670                1675                1680
Ser Asp Ser Glu Tyr Glu Val Asp Ser Asn His Gln Lys Ala His Ser
                1685                1690                1695    
Phe Val Asn His Tyr Ile Ser Asp Pro Thr Tyr Tyr Asn Ser Trp Arg
            1700                1705                1710        
Arg Gln Gln Lys Gly Ile Ser Arg Ala Gln Ala Tyr Ser Tyr Thr Glu
        1715                1720                1725            
Ser Asp Ser Gly Glu Pro Asp His Thr Thr Val Thr Asn Ser Thr Ser
    1730                1735                1740                
Thr Gln Gln Gly Ser Leu Phe Arg Pro Lys Ala Ser Arg Thr Pro Thr
1745                1750                1755                1760
Pro Gln Asn Pro Pro Asn Pro Pro Ser Gln Gln Ser Thr Leu Tyr His
                1765                1770                1775    
Ser Arg Ala Ser Lys Ala Gly Val Gln Lys Glu Gly Glu Asn Arg Glu
            1780                1785                1790        
Arg Met Cys Val Ala Ser Ser Ser Ser Ala Leu Arg Trp Trp Gly Ser
        1795                1800                1805            
Leu Leu Pro Trp Glu Leu His Gly Ala Gly Glu Val Ala Val Ser Leu
    1810                1815                1820                
Leu Trp Thr Arg Ser Gly Ala Gly Ile Trp Arg Glu Arg Gly Ser Gly
1825                1830                1835                1840
Gly
    


<210> 6457
<211> 1329
<212> PRT
<213> Homo sapiens

<400> 6457
Gln Gly Tyr Lys Leu Ile Ala Trp Glu Pro Glu Gln Glu Glu Glu Val
 1               5                  10                  15      
Thr Met Val Thr Ala Arg Pro Asn Phe Gln Asp Ser Ile His Val Gly
            20                  25                  30          
Phe Val Ser Gly Leu Lys Lys Phe Thr Glu Tyr Phe Thr Ser Val Leu
        35                  40                  45              
Cys Phe Thr Thr Pro Gly Asp Gly Pro Arg Ser Thr Pro Gln Leu Val
    50                  55                  60                  
Arg Thr His Glu Asp Val Pro Gly Pro Val Gly His Leu Ser Phe Ser
65                  70                  75                  80  
Glu Ile Leu Asp Thr Ser Leu Lys Val Ser Trp Gln Glu Pro Gly Glu
                85                  90                  95      
Lys Asn Gly Ile Leu Thr Gly Tyr Arg Ile Ser Trp Glu Glu Tyr Asn
            100                 105                 110         
Arg Thr Asn Thr Arg Val Thr His Tyr Leu Pro Asn Val Thr Leu Glu
        115                 120                 125             
Tyr Arg Val Thr Gly Leu Thr Ala Leu Thr Thr Tyr Thr Ile Glu Val
    130                 135                 140                 
Ala Ala Met Thr Ser Lys Gly Gln Gly Gln Val Ser Ala Ser Thr Ile
145                 150                 155                 160 
Ser Ser Gly Val Pro Pro Glu Leu Pro Gly Pro Pro Thr Asn Leu Gly
                165                 170                 175     
Ile Ser Asn Ile Gly Pro Arg Ser Val Thr Leu Gln Phe Arg Pro Gly
            180                 185                 190         
Tyr Asp Gly Lys Thr Ser Ile Ser Arg Trp Leu Val Glu Ala Gln Val
        195                 200                 205             
Gly Val Val Gly Glu Gly Glu Glu Trp Leu Leu Ile His Gln Leu Ser
    210                 215                 220                 
Asn Glu Pro Asp Ala Arg Ser Met Glu Val Pro Asp Leu Asn Pro Phe
225                 230                 235                 240 
Thr Cys Tyr Ser Phe Arg Met Arg Gln Val Asn Ile Val Gly Thr Ser
                245                 250                 255     
Pro Pro Ser Gln Pro Ser Arg Lys Ile Gln Thr Leu Gln Ala Pro Pro
            260                 265                 270         
Asp Met Ala Pro Ala Asn Val Ser Leu Arg Thr Ala Ser Glu Thr Ser
        275                 280                 285             
Leu Trp Leu Arg Trp Met Pro Leu Pro Glu Met Glu Tyr Asn Gly Asn
    290                 295                 300                 
Pro Glu Ser Val Gly Tyr Lys Ile Lys Tyr Ser Arg Ser Asp Gly His
305                 310                 315                 320 
Gly Lys Thr Leu Ser His Val Val Gln Asp Arg Val Glu Arg Asp Tyr
                325                 330                 335     
Thr Ile Glu Asp Leu Glu Glu Trp Thr Glu Tyr Arg Val Gln Val Gln
            340                 345                 350         
Ala Phe Asn Ala Ile Gly Ser Gly Pro Trp Ser Gln Thr Val Val Gly
        355                 360                 365             
Arg Thr Arg Glu Ser Val Pro Ser Ser Gly Pro Thr Asn Val Ser Ala
    370                 375                 380                 
Leu Ala Thr Thr Ser Ser Ser Met Leu Val Arg Trp Ser Glu Val Pro
385                 390                 395                 400 
Glu Ala Asp Arg Asn Gly Leu Val Leu Gly Tyr Lys Val Met Tyr Lys
                405                 410                 415     
Glu Lys Asp Ser Asp Thr Gln Pro Arg Phe Trp Leu Val Glu Gly Asn
            420                 425                 430         
Ser Ser Arg Ser Ala Gln Leu Thr Gly Leu Gly Lys Tyr Val Leu Tyr
        435                 440                 445             
Glu Val Gln Val Leu Ala Phe Thr Arg Ile Gly Asp Gly Ser Pro Ser
    450                 455                 460                 
His Pro Pro Ile Leu Glu Arg Thr Leu Asp Asp Val Pro Gly Pro Pro
465                 470                 475                 480 
Met Gly Ile Leu Phe Pro Glu Val Arg Thr Thr Ser Val Arg Leu Ile
                485                 490                 495     
Trp Gln Pro Pro Ala Ala Pro Asn Gly Ile Ile Leu Ala Tyr Gln Ile
            500                 505                 510         
Thr His Arg Leu Asn Thr Thr Thr Ala Asn Thr Ala Thr Val Glu Val
        515                 520                 525             
Leu Ala Pro Ser Ala Arg Gln Tyr Thr Ala Thr Gly Leu Lys Pro Glu
    530                 535                 540                 
Ser Val Tyr Leu Phe Arg Ile Thr Ala Gln Thr Arg Lys Gly Trp Gly
545                 550                 555                 560 
Glu Ala Ala Glu Ala Leu Val Val Thr Thr Glu Lys Arg Asp Arg Pro
                565                 570                 575     
Gln Pro Pro Ser Arg Pro Met Val Gln Gln Glu Asp Val Arg Ala Arg
            580                 585                 590         
Ser Val Leu Leu Ser Trp Glu Pro Gly Ser Asp Gly Leu Ser Pro Val
        595                 600                 605             
Arg Tyr Tyr Thr Ile Gln Thr Arg Glu Leu Pro Ser Gly Arg Trp Ala
    610                 615                 620                 
Leu His Ser Ala Ser Val Ser His Asn Ala Ser Ser Phe Ile Val Asp
625                 630                 635                 640 
Arg Leu Lys Pro Phe Thr Ser Tyr Lys Phe Arg Val Lys Ala Thr Asn
                645                 650                 655     
Asp Ile Gly Asp Ser Glu Phe Ser Glu Glu Ser Glu Ser Leu Thr Thr
            660                 665                 670         
Leu Gln Ala Ala Pro Asp Glu Ala Pro Thr Ile Leu Ser Val Thr Pro
        675                 680                 685             
His Thr Thr Thr Ser Val Leu Ile Arg Trp Gln Pro Pro Ala Glu Asp
    690                 695                 700                 
Lys Ile Asn Gly Ile Leu Leu Gly Phe Arg Ile Arg Tyr Arg Glu Leu
705                 710                 715                 720 
Leu Tyr Glu Gly Leu Arg Gly Phe Met Leu Arg Gly Ile Asn Asn Pro
                725                 730                 735     
Gly Ala Thr Trp Ala Glu Leu Thr Tyr Leu Asn Lys His Arg Arg Tyr
            740                 745                 750         
Glu Ile Arg Met Ser Val Tyr Asn Ala Val Gly Glu Gly Pro Ser Ser
        755                 760                 765             
Pro Pro Gln Glu Val Phe Val Gly Glu Ala Val Pro Thr Ala Ala Pro
    770                 775                 780                 
Arg Asn Val Val Val His Gly Ala Thr Ala Thr Gln Leu Asp Val Thr
785                 790                 795                 800 
Trp Glu Pro Pro Pro Leu Asp Ser Gln Asn Gly Asp Ile Gln Gly Tyr
                805                 810                 815     
Lys Ile Tyr Phe Trp Glu Ala Gln Arg Gly Asn Leu Thr Glu Arg Val
            820                 825                 830         
Lys Thr Leu Phe Leu Ala Glu Asn Ser Val Lys Leu Lys Asn Leu Thr
        835                 840                 845             
Gly Tyr Thr Ala Tyr Met Val Ser Val Ala Ala Phe Asn Ala Ala Gly
    850                 855                 860                 
Asp Gly Pro Arg Ser Thr Pro Thr Gln Gly Gln Thr Gln Gln Ala Ala
865                 870                 875                 880 
Pro Ser Ala Pro Ser Ser Val Lys Phe Ser Glu Leu Thr Thr Thr Ser
                885                 890                 895     
Val Asn Val Ser Trp Glu Ala Pro Gln Phe Pro Asn Gly Ile Leu Glu
            900                 905                 910         
Gly Tyr Arg Leu Val Tyr Glu Pro Cys Ser Pro Val Asp Gly Val Ser
        915                 920                 925             
Lys Ile Val Thr Val Asp Val Lys Gly Asn Ser Pro Leu Trp Leu Lys
    930                 935                 940                 
Val Lys Asp Leu Ala Glu Gly Val Thr Tyr Arg Phe Arg Ile Arg Ala
945                 950                 955                 960 
Lys Thr Phe Thr Tyr Gly Pro Glu Ile Glu Ala Asn Val Thr Thr Gly
                965                 970                 975     
Pro Gly Glu Gly Ala Pro Gly Pro Pro Gly Val Pro Ile Ile Val Arg
            980                 985                 990         
Tyr Ser Ser Ala Ile Ala Ile His Trp Ser Ser Gly Asp Pro Gly Lys
        995                 1000                1005            
Gly Pro Ile Thr Arg Tyr Val Ile Glu Ala Arg Pro Ser Asp Glu Gly
    1010                1015                1020                
Leu Trp Asp Ile Leu Ile Lys Asp Ile Pro Lys Glu Val Ser Ser Tyr
1025                1030                1035                1040
Thr Phe Ser Met Asp Ile Leu Lys Pro Gly Val Ser Tyr Asp Phe Arg
                1045                1050                1055    
Val Ile Ala Val Asn Asp Tyr Gly Phe Gly Thr Pro Ser Ser Pro Ser
            1060                1065                1070        
Gln Ser Val Pro Ala Gln Lys Ala Asn Pro Phe Tyr Glu Glu Trp Trp
        1075                1080                1085            
Phe Leu Val Val Ile Ala Leu Val Gly Leu Ile Phe Ile Leu Leu Leu
    1090                1095                1100                
Val Phe Val Leu Ile Ile Arg Gly Gln Ser Lys Lys Tyr Ala Lys Lys
1105                1110                1115                1120
Thr Asp Ser Gly Asn Ser Ala Lys Ser Gly Ala Leu Gly His Ser Glu
                1125                1130                1135    
Met Met Ser Leu Asp Glu Ser Ser Phe Pro Ala Leu Glu Leu Asn Asn
            1140                1145                1150        
Arg Arg Leu Ser Val Lys Asn Ser Phe Cys Arg Lys Asn Gly Leu Tyr
        1155                1160                1165            
Thr Arg Ser Pro Pro Arg Pro Ser Pro Gly Ser Leu His Tyr Ser Asp
    1170                1175                1180                
Glu Asp Val Thr Lys Tyr Asn Asp Leu Ile Pro Ala Glu Ser Ser Ser
1185                1190                1195                1200
Leu Thr Glu Lys Pro Ser Glu Ile Ser Asp Ser Gln Gly Ser Asp Ser
                1205                1210                1215    
Glu Tyr Glu Val Asp Ser Asn His Gln Lys Ala His Ser Phe Val Asn
            1220                1225                1230        
His Tyr Ile Ser Asp Pro Thr Tyr Tyr Asn Ser Trp Arg Arg Gln Gln
        1235                1240                1245            
Lys Gly Ile Ser Arg Ala Gln Ala Tyr Ser Tyr Thr Glu Ser Asp Ser
    1250                1255                1260                
Gly Glu Pro Asp His Thr Thr Val Thr Asn Ser Thr Ser Thr Gln Gln
1265                1270                1275                1280
Gly Ser Leu Phe Arg Pro Lys Ala Ser Arg Thr Pro Thr Pro Gln Asn
                1285                1290                1295    
Pro Pro Asn Pro Pro Ser Gln Gln Ser Thr Leu Tyr Arg Pro Pro Ser
            1300                1305                1310        
Ser Leu Ala Pro Gly Ser Arg Ala Pro Ile Ala Gly Phe Ser Ser Phe
        1315                1320                1325            
Val
    


<210> 6458
<211> 1598
<212> PRT
<213> Homo sapiens

<400> 6458
Lys Val Val Asp Ile Pro Cys Gln Ala Lys Gly Val Pro Pro Pro Ser
 1               5                  10                  15      
Ile Thr Trp Tyr Lys Asp Ala Ala Val Val Glu Val Glu Lys Leu Thr
            20                  25                  30          
Arg Phe Arg Gln Arg Asn Asp Gly Gly Leu Gln Ile Ser Gly Leu Val
        35                  40                  45              
Pro Asp Asp Thr Gly Met Phe Gln Cys Phe Ala Arg Asn Ala Ala Gly
    50                  55                  60                  
Glu Val Gln Thr Ser Thr Tyr Leu Ala Val Thr Ser Ile Ala Pro Asn
65                  70                  75                  80  
Ile Thr Arg Gly Pro Leu Asp Ser Thr Val Ile Asp Gly Met Ser Val
                85                  90                  95      
Val Leu Ala Cys Glu Thr Ser Gly Ala Pro Arg Pro Ala Ile Thr Trp
            100                 105                 110         
Gln Lys Gly Glu Arg Ile Leu Ala Ser Gly Ser Val Gln Leu Pro Arg
        115                 120                 125             
Phe Thr Pro Leu Glu Ser Gly Ser Leu Leu Ile Ser Pro Thr His Ile
    130                 135                 140                 
Ser Asp Ala Gly Thr Tyr Thr Cys Leu Ala Thr Asn Ser Arg Gly Val
145                 150                 155                 160 
Asp Glu Ala Ser Ala Asp Leu Val Val Trp Ala Arg Thr Arg Ile Thr
                165                 170                 175     
Lys Pro Pro Gln Asp Gln Ser Val Ile Lys Gly Thr Gln Ala Ser Met
            180                 185                 190         
Val Cys Gly Val Thr His Asp Pro Arg Val Thr Ile Arg Tyr Ile Trp
        195                 200                 205             
Glu Lys Asp Gly Ala Thr Leu Gly Thr Glu Ser His Pro Arg Ile Arg
    210                 215                 220                 
Leu Asp Arg Asn Gly Ser Leu His Ile Ser Gln Thr Trp Ser Gly Asp
225                 230                 235                 240 
Ile Gly Thr Tyr Thr Cys Arg Val Ile Ser Ala Gly Gly Asn Asp Ser
                245                 250                 255     
Arg Ser Ala His Leu Arg Val Arg Gln Leu Pro His Ala Pro Glu His
            260                 265                 270         
Pro Val Ala Thr Leu Ser Thr Val Glu Arg Arg Ala Ile Asn Leu Thr
        275                 280                 285             
Trp Thr Lys Pro Phe Asp Gly Asn Ser Pro Leu Ile Arg Tyr Ile Leu
    290                 295                 300                 
Glu Met Ser Glu Asn Asn Ala Pro Trp Thr Val Leu Leu Ala Ser Val
305                 310                 315                 320 
Asp Pro Lys Ala Thr Ser Val Thr Val Lys Gly Leu Val Pro Ala Arg
                325                 330                 335     
Ser Tyr Gln Phe Arg Leu Cys Ala Val Asn Asp Val Gly Lys Gly Gln
            340                 345                 350         
Phe Ser Lys Asp Thr Glu Arg Val Ser Leu Pro Glu Glu Pro Pro Thr
        355                 360                 365             
Ala Pro Pro Gln Asn Val Ile Ala Ser Gly Arg Thr Asn Gln Ser Ile
    370                 375                 380                 
Met Ile Gln Trp Gln Pro Pro Pro Glu Ser His Gln Asn Gly Ile Leu
385                 390                 395                 400 
Lys Gly Tyr Ile Ile Arg Tyr Cys Leu Ala Gly Leu Pro Val Gly Tyr
                405                 410                 415     
Gln Phe Lys Asn Ile Thr Asp Ala Asp Val Asn Asn Leu Leu Leu Glu
            420                 425                 430         
Asp Leu Ile Ile Trp Thr Asn Tyr Glu Ile Glu Val Ala Ala Tyr Asn
        435                 440                 445             
Ser Ala Gly Leu Gly Val Tyr Ser Ser Lys Val Thr Glu Trp Thr Leu
    450                 455                 460                 
Gln Gly Val Pro Thr Val Pro Pro Gly Asn Val His Ala Glu Ala Thr
465                 470                 475                 480 
Asn Ser Thr Thr Ile Arg Phe Thr Trp Asn Ala Pro Ser Pro Gln Phe
                485                 490                 495     
Ile Asn Gly Ile Asn Gln Gly Tyr Lys Leu Ile Ala Trp Glu Pro Glu
            500                 505                 510         
Gln Glu Glu Glu Val Thr Met Val Thr Ala Arg Pro Asn Phe Gln Asp
        515                 520                 525             
Ser Ile His Val Gly Phe Val Ser Gly Leu Lys Lys Phe Thr Glu Tyr
    530                 535                 540                 
Phe Thr Ser Val Leu Cys Phe Thr Thr Pro Gly Asp Gly Pro Arg Ser
545                 550                 555                 560 
Thr Pro Gln Leu Val Arg Thr His Glu Asp Val Pro Gly Pro Val Gly
                565                 570                 575     
His Leu Ser Phe Ser Glu Ile Leu Asp Thr Ser Leu Lys Val Ser Trp
            580                 585                 590         
Gln Glu Pro Gly Glu Lys Asn Gly Ile Leu Thr Gly Tyr Arg Ile Ser
        595                 600                 605             
Trp Glu Glu Tyr Asn Arg Thr Asn Thr Arg Val Thr His Tyr Leu Pro
    610                 615                 620                 
Asn Val Thr Leu Glu Tyr Arg Val Thr Gly Leu Thr Ala Leu Thr Thr
625                 630                 635                 640 
Tyr Thr Ile Glu Val Ala Ala Met Thr Ser Lys Gly Gln Gly Gln Val
                645                 650                 655     
Ser Ala Ser Thr Ile Ser Ser Gly Val Pro Pro Glu Leu Pro Gly Pro
            660                 665                 670         
Pro Thr Asn Leu Gly Ile Ser Asn Ile Gly Pro Arg Ser Val Thr Leu
        675                 680                 685             
Gln Phe Arg Pro Gly Tyr Asp Gly Lys Thr Ser Ile Ser Arg Trp Leu
    690                 695                 700                 
Val Glu Ala Gln Val Gly Val Val Gly Glu Gly Glu Glu Trp Leu Leu
705                 710                 715                 720 
Ile His Gln Leu Ser Asn Glu Pro Asp Ala Arg Ser Met Glu Val Pro
                725                 730                 735     
Asp Leu Asn Pro Phe Thr Cys Tyr Ser Phe Arg Met Arg Gln Val Asn
            740                 745                 750         
Ile Val Gly Thr Ser Pro Pro Ser Gln Pro Ser Arg Lys Ile Gln Thr
        755                 760                 765             
Leu Gln Ala Pro Pro Asp Met Ala Pro Ala Asn Val Ser Leu Arg Thr
    770                 775                 780                 
Ala Ser Glu Thr Ser Leu Trp Leu Arg Trp Met Pro Leu Pro Glu Met
785                 790                 795                 800 
Glu Tyr Asn Gly Asn Pro Glu Ser Val Gly Tyr Lys Ile Lys Tyr Ser
                805                 810                 815     
Arg Ser Asp Gly His Gly Lys Thr Leu Ser His Val Val Gln Asp Arg
            820                 825                 830         
Val Glu Arg Asp Tyr Thr Ile Glu Asp Leu Glu Glu Trp Thr Glu Tyr
        835                 840                 845             
Arg Val Gln Val Gln Ala Phe Asn Ala Ile Gly Ser Gly Pro Trp Ser
    850                 855                 860                 
Gln Thr Val Val Gly Arg Thr Arg Glu Ser Val Pro Ser Ser Gly Pro
865                 870                 875                 880 
Thr Asn Val Ser Ala Leu Ala Thr Thr Ser Ser Ser Met Leu Val Arg
                885                 890                 895     
Trp Ser Glu Val Pro Glu Ala Asp Arg Asn Gly Leu Val Leu Gly Tyr
            900                 905                 910         
Lys Val Met Tyr Lys Glu Lys Asp Ser Asp Thr Gln Pro Arg Phe Trp
        915                 920                 925             
Leu Val Glu Gly Asn Ser Ser Arg Ser Ala Gln Leu Thr Gly Leu Gly
    930                 935                 940                 
Lys Tyr Val Leu Tyr Glu Val Gln Val Leu Ala Phe Thr Arg Ile Gly
945                 950                 955                 960 
Asp Gly Ser Pro Ser His Pro Pro Ile Leu Glu Arg Thr Leu Asp Asp
                965                 970                 975     
Val Pro Gly Pro Pro Met Gly Ile Leu Phe Pro Glu Val Arg Thr Thr
            980                 985                 990         
Ser Val Arg Leu Ile Trp Gln Pro Pro Ala Ala Pro Asn Gly Ile Ile
        995                 1000                1005            
Leu Ala Tyr Gln Ile Thr His Arg Leu Asn Thr Thr Thr Ala Asn Thr
    1010                1015                1020                
Ala Thr Val Glu Val Leu Ala Pro Ser Ala Arg Gln Tyr Thr Ala Thr
1025                1030                1035                1040
Gly Leu Lys Pro Glu Ser Val Tyr Leu Phe Arg Ile Thr Ala Gln Thr
                1045                1050                1055    
Arg Lys Gly Trp Gly Glu Ala Ala Glu Ala Leu Val Val Thr Thr Glu
            1060                1065                1070        
Lys Arg Asp Arg Pro Gln Pro Pro Ser Arg Pro Met Val Gln Gln Glu
        1075                1080                1085            
Asp Val Arg Ala Arg Ser Val Leu Leu Ser Trp Glu Pro Gly Ser Asp
    1090                1095                1100                
Gly Leu Ser Pro Val Arg Tyr Tyr Thr Ile Gln Thr Arg Glu Leu Pro
1105                1110                1115                1120
Ser Gly Arg Trp Ala Leu His Ser Ala Ser Val Ser His Asn Ala Ser
                1125                1130                1135    
Ser Phe Ile Val Asp Arg Leu Lys Pro Phe Thr Ser Tyr Lys Phe Arg
            1140                1145                1150        
Val Lys Ala Thr Asn Asp Ile Gly Asp Ser Glu Phe Ser Glu Glu Ser
        1155                1160                1165            
Glu Ser Leu Thr Thr Leu Gln Ala Ala Pro Asp Glu Ala Pro Thr Ile
    1170                1175                1180                
Leu Ser Val Thr Pro His Thr Thr Thr Ser Val Leu Ile Arg Trp Gln
1185                1190                1195                1200
Pro Pro Ala Glu Asp Lys Ile Asn Gly Ile Leu Leu Gly Phe Arg Ile
                1205                1210                1215    
Arg Tyr Arg Glu Leu Leu Tyr Glu Gly Leu Arg Gly Phe Thr Leu Arg
            1220                1225                1230        
Gly Ile Asn Asn Pro Gly Ala Thr Trp Ala Glu Leu Thr Ser Met Tyr
        1235                1240                1245            
Ser Met Arg Asn Leu Ser Arg Pro Ser Leu Thr Gln Tyr Glu Leu Asp
    1250                1255                1260                
Asn Leu Asn Lys His Arg Arg Tyr Glu Ile Arg Met Ser Val Tyr Asn
1265                1270                1275                1280
Ala Val Gly Glu Gly Pro Ser Ser Pro Pro Gln Glu Val Phe Val Gly
                1285                1290                1295    
Glu Ala Val Pro Thr Ala Ala Pro Arg Asn Val Val Val His Gly Ala
            1300                1305                1310        
Thr Ala Thr Gln Leu Asp Val Thr Trp Glu Pro Pro Pro Leu Asp Ser
        1315                1320                1325            
Gln Asn Gly Asp Ile Gln Gly Tyr Lys Ile Tyr Phe Trp Glu Ala Gln
    1330                1335                1340                
Arg Gly Asn Leu Thr Glu Arg Val Lys Thr Leu Phe Leu Ala Glu Asn
1345                1350                1355                1360
Ser Val Lys Leu Lys Asn Leu Thr Gly Tyr Thr Ala Tyr Met Val Ser
                1365                1370                1375    
Val Ala Ala Phe Asn Ala Ala Gly Asp Gly Pro Arg Ser Thr Pro Thr
            1380                1385                1390        
Gln Gly Gln Thr Gln Gln Ala Ala Pro Ser Ala Pro Ser Ser Val Lys
        1395                1400                1405            
Phe Ser Glu Leu Thr Thr Thr Ser Val Asn Val Ser Trp Glu Ala Pro
    1410                1415                1420                
Gln Phe Pro Asn Gly Ile Leu Glu Gly Tyr Arg Leu Val Tyr Glu Pro
1425                1430                1435                1440
Cys Ser Pro Val Asp Gly Val Ser Lys Ile Val Thr Val Asp Val Lys
                1445                1450                1455    
Gly Asn Ser Pro Leu Trp Leu Lys Val Lys Asp Leu Ala Glu Gly Val
            1460                1465                1470        
Thr Tyr Arg Phe Arg Ile Arg Ala Lys Thr Phe Thr Tyr Gly Pro Glu
        1475                1480                1485            
Ile Glu Ala Asn Val Thr Thr Gly Pro Gly Glu Gly Ala Pro Gly Pro
    1490                1495                1500                
Pro Gly Val Pro Ile Ile Val Arg Tyr Ser Ser Ala Ile Ala Ile His
1505                1510                1515                1520
Trp Ser Ser Gly Asp Pro Gly Lys Gly Pro Ile Thr Arg Tyr Val Ile
                1525                1530                1535    
Glu Ala Arg Pro Ser Gly Ala Pro Arg Pro Ala Gly Leu Arg Pro His
            1540                1545                1550        
Ser Ser Leu Ser Pro Phe Phe Leu Gly Pro Ser Thr Trp Gly Thr Cys
        1555                1560                1565            
Leu Cys Pro Pro Pro Glu Lys Ala Leu Val Leu Leu Gln Val Lys Ser
    1570                1575                1580                
Pro Gly Pro Val Glu Glu Trp Glu Thr Gly Leu Gly Gly Ser
1585                1590                1595            


<210> 6459
<211> 1454
<212> PRT
<213> Homo sapiens

<400> 6459
Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu Cys Val
 1               5                  10                  15      
Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg Lys Leu
            20                  25                  30          
Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln Lys Asn
        35                  40                  45              
Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser Pro Ile
    50                  55                  60                  
Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys Lys Leu
65                  70                  75                  80  
Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe Ile His
                85                  90                  95      
Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr Arg Val
            100                 105                 110         
Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile Thr Phe
        115                 120                 125             
His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His Ser Leu
    130                 135                 140                 
Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe Asp Ala
145                 150                 155                 160 
Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly Lys Leu
                165                 170                 175     
Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn Leu Asp
            180                 185                 190         
Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe Gly Lys
        195                 200                 205             
Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro Asn Ser
    210                 215                 220                 
Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro Pro Cys
225                 230                 235                 240 
Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser Ile Ser
                245                 250                 255     
Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln Gln Ser
            260                 265                 270         
Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg Glu Gln
        275                 280                 285             
Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly Lys Glu
    290                 295                 300                 
Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val Gln Ala
305                 310                 315                 320 
Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg Pro Arg
                325                 330                 335     
Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr Gln Gln
            340                 345                 350         
Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp Gly Tyr
        355                 360                 365             
Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met Ser Tyr
    370                 375                 380                 
Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly Lys Tyr
385                 390                 395                 400 
Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu Leu Asp
                405                 410                 415     
Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu Glu Glu
            420                 425                 430         
Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly Arg Asp
        435                 440                 445             
Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser Thr Thr
    450                 455                 460                 
Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys Thr Asn
465                 470                 475                 480 
Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp Val Pro
                485                 490                 495     
Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu Ala Thr
            500                 505                 510         
Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu Pro Pro
        515                 520                 525             
His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser Lys Thr
    530                 535                 540                 
Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu Ser Leu
545                 550                 555                 560 
Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu Thr Ser
                565                 570                 575     
Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser Pro Ala
            580                 585                 590         
Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly Tyr Ile
        595                 600                 605             
Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu Ile Pro
    610                 615                 620                 
Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly Ser Glu
625                 630                 635                 640 
Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe Pro Ser
                645                 650                 655     
Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg Glu Ser
            660                 665                 670         
Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser Glu Lys
        675                 680                 685             
Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly Pro Ser
    690                 695                 700                 
Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr Phe Pro
705                 710                 715                 720 
Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln Gln Asp
                725                 730                 735     
Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln Pro Val
            740                 745                 750         
Tyr Asn Ala Ser Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu
        755                 760                 765             
Gly Leu Glu Ser Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser
    770                 775                 780                 
Ala Leu Thr Phe Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr
785                 790                 795                 800 
Trp Arg Lys Cys Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Ser Thr
                805                 810                 815     
Ser Pro Arg Val Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser
            820                 825                 830         
Asp Asp Val Gly Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala
        835                 840                 845             
Asp Leu His Ala Ser Ser Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys
    850                 855                 860                 
Glu Phe Tyr Gln Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr
865                 870                 875                 880 
Ala Asp Ser Ser Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Ile
                885                 890                 895     
Asn Ile Val Ala Tyr Asp His Ser Arg Val Lys Leu Ala Gln Leu Ala
            900                 905                 910         
Glu Lys Asp Gly Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp
        915                 920                 925             
Gly Tyr Asn Arg Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys
    930                 935                 940                 
Ser Thr Ala Glu Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu
945                 950                 955                 960 
Val Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys
                965                 970                 975     
Asp Gln Tyr Trp Pro Ala Asp Gly Ser Glu Glu Tyr Gly Asn Phe Leu
            980                 985                 990         
Val Thr Gln Lys Ser Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn
        995                 1000                1005            
Phe Thr Leu Arg Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg
    1010                1015                1020                
Pro Ser Gly Arg Val Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp
1025                1030                1035                1040
Met Gly Val Pro Glu Tyr Ser Leu Pro Val Leu Thr Phe Val Arg Lys
                1045                1050                1055    
Ala Ala Tyr Ala Lys Arg His Ala Val Gly Pro Val Val Val His Cys
            1060                1065                1070        
Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met
        1075                1080                1085            
Leu Gln Gln Ile Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu
    1090                1095                1100                
Lys His Ile Arg Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln
1105                1110                1115                1120
Tyr Val Phe Ile His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu
                1125                1130                1135    
Thr Glu Val Leu Asp Ser His Ile His Ala Tyr Val Asn Ala Leu Leu
            1140                1145                1150        
Ile Pro Gly Pro Ala Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu
        1155                1160                1165            
Leu Ser Gln Ser Asn Ile Gln Gln Ser Asp Tyr Ser Ala Ala Leu Lys
    1170                1175                1180                
Gln Cys Asn Arg Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu
1185                1190                1195                1200
Arg Ser Arg Val Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr
                1205                1210                1215    
Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile
            1220                1225                1230        
Ile Thr Gln His Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met
        1235                1240                1245            
Ile Trp Asp His Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln
    1250                1255                1260                
Asn Met Ala Glu Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro
1265                1270                1275                1280
Ile Asn Cys Glu Ser Phe Lys Val Thr Leu Met Ala Glu Glu His Lys
                1285                1290                1295    
Cys Leu Ser Asn Glu Glu Lys Leu Ile Ile Gln Asp Phe Ile Leu Glu
            1300                1305                1310        
Ala Thr Gln Asp Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro
        1315                1320                1325            
Lys Trp Pro Asn Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile
    1330                1335                1340                
Ser Val Ile Lys Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val
1345                1350                1355                1360
His Asp Glu His Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr
                1365                1370                1375    
Thr Leu Met His Gln Leu Glu Lys Glu Asn Ser Val Asp Val Tyr Gln
            1380                1385                1390        
Val Ala Lys Met Ile Asn Leu Met Arg Pro Gly Val Phe Ala Asp Ile
        1395                1400                1405            
Glu Gln Tyr Gln Phe Leu Tyr Lys Val Ile Leu Ser Leu Val Ser Thr
    1410                1415                1420                
Arg Gln Glu Glu Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala
1425                1430                1435                1440
Leu Pro Asp Gly Asn Ile Ala Glu Ser Leu Glu Ser Leu Val
                1445                1450                


<210> 6460
<211> 2365
<212> PRT
<213> Homo sapiens

<400> 6460
Lys His Thr Tyr Ala Arg Thr Ile Ser Leu Arg Ser Ile His Trp Arg
 1               5                  10                  15      
Ile Lys Thr Asn Lys Gln Lys Lys His Phe Leu Arg Ser Pro Ser Leu
            20                  25                  30          
Ser Thr Leu Arg Ser Arg Gly Ala Ala Arg Arg Gly Ala Ala Asp Arg
        35                  40                  45              
Leu Glu Met Arg Ile Leu Lys Arg Phe Leu Ala Cys Ile Gln Leu Leu
    50                  55                  60                  
Cys Val Cys Arg Leu Asp Trp Ala Asn Gly Tyr Tyr Arg Gln Gln Arg
65                  70                  75                  80  
Lys Leu Val Glu Glu Ile Gly Trp Ser Tyr Thr Gly Ala Leu Asn Gln
                85                  90                  95      
Lys Asn Trp Gly Lys Lys Tyr Pro Thr Cys Asn Ser Pro Lys Gln Ser
            100                 105                 110         
Pro Ile Asn Ile Asp Glu Asp Leu Thr Gln Val Asn Val Asn Leu Lys
        115                 120                 125             
Lys Leu Lys Phe Gln Gly Trp Asp Lys Thr Ser Leu Glu Asn Thr Phe
    130                 135                 140                 
Ile His Asn Thr Gly Lys Thr Val Glu Ile Asn Leu Thr Asn Asp Tyr
145                 150                 155                 160 
Arg Val Ser Gly Gly Val Ser Glu Met Val Phe Lys Ala Ser Lys Ile
                165                 170                 175     
Thr Phe His Trp Gly Lys Cys Asn Met Ser Ser Asp Gly Ser Glu His
            180                 185                 190         
Ser Leu Glu Gly Gln Lys Phe Pro Leu Glu Met Gln Ile Tyr Cys Phe
        195                 200                 205             
Asp Ala Asp Arg Phe Ser Ser Phe Glu Glu Ala Val Lys Gly Lys Gly
    210                 215                 220                 
Lys Leu Arg Ala Leu Ser Ile Leu Phe Glu Val Gly Thr Glu Glu Asn
225                 230                 235                 240 
Leu Asp Phe Lys Ala Ile Ile Asp Gly Val Glu Ser Val Ser Arg Phe
                245                 250                 255     
Gly Lys Gln Ala Ala Leu Asp Pro Phe Ile Leu Leu Asn Leu Leu Pro
            260                 265                 270         
Asn Ser Thr Asp Lys Tyr Tyr Ile Tyr Asn Gly Ser Leu Thr Ser Pro
        275                 280                 285             
Pro Cys Thr Asp Thr Val Asp Trp Ile Val Phe Lys Asp Thr Val Ser
    290                 295                 300                 
Ile Ser Glu Ser Gln Leu Ala Val Phe Cys Glu Val Leu Thr Met Gln
305                 310                 315                 320 
Gln Ser Gly Tyr Val Met Leu Met Asp Tyr Leu Gln Asn Asn Phe Arg
                325                 330                 335     
Glu Gln Gln Tyr Lys Phe Ser Arg Gln Val Phe Ser Ser Tyr Thr Gly
            340                 345                 350         
Lys Glu Glu Ile His Glu Ala Val Cys Ser Ser Glu Pro Glu Asn Val
        355                 360                 365             
Gln Ala Asp Pro Glu Asn Tyr Thr Ser Leu Leu Val Thr Trp Glu Arg
    370                 375                 380                 
Pro Arg Val Val Tyr Asp Thr Met Ile Glu Lys Phe Ala Val Leu Tyr
385                 390                 395                 400 
Gln Gln Leu Asp Gly Glu Asp Gln Thr Lys His Glu Phe Leu Thr Asp
                405                 410                 415     
Gly Tyr Gln Asp Leu Gly Ala Ile Leu Asn Asn Leu Leu Pro Asn Met
            420                 425                 430         
Ser Tyr Val Leu Gln Ile Val Ala Ile Cys Thr Asn Gly Leu Tyr Gly
        435                 440                 445             
Lys Tyr Ser Asp Gln Leu Ile Val Asp Met Pro Thr Asp Asn Pro Glu
    450                 455                 460                 
Leu Asp Leu Phe Pro Glu Leu Ile Gly Thr Glu Glu Ile Ile Lys Glu
465                 470                 475                 480 
Glu Glu Glu Gly Lys Asp Ile Glu Glu Gly Ala Ile Val Asn Pro Gly
                485                 490                 495     
Arg Asp Ser Ala Thr Asn Gln Ile Arg Lys Lys Glu Pro Gln Ile Ser
            500                 505                 510         
Thr Thr Thr His Tyr Asn Arg Ile Gly Thr Lys Tyr Asn Glu Ala Lys
        515                 520                 525             
Thr Asn Arg Ser Pro Thr Arg Gly Ser Glu Phe Ser Gly Lys Gly Asp
    530                 535                 540                 
Val Pro Asn Thr Ser Leu Asn Ser Thr Ser Gln Pro Val Thr Lys Leu
545                 550                 555                 560 
Ala Thr Glu Lys Asp Ile Ser Leu Thr Ser Gln Thr Val Thr Glu Leu
                565                 570                 575     
Pro Pro His Thr Val Glu Gly Thr Ser Ala Ser Leu Asn Asp Gly Ser
            580                 585                 590         
Lys Thr Val Leu Arg Ser Pro His Met Asn Leu Ser Gly Thr Ala Glu
        595                 600                 605             
Ser Leu Asn Thr Val Ser Ile Thr Glu Tyr Glu Glu Glu Ser Leu Leu
    610                 615                 620                 
Thr Ser Phe Lys Leu Asp Thr Gly Ala Glu Asp Ser Ser Gly Ser Ser
625                 630                 635                 640 
Pro Ala Thr Ser Ala Ile Pro Phe Ile Ser Glu Asn Ile Ser Gln Gly
                645                 650                 655     
Tyr Ile Phe Ser Ser Glu Asn Pro Glu Thr Ile Thr Tyr Asp Val Leu
            660                 665                 670         
Ile Pro Glu Ser Ala Arg Asn Ala Ser Glu Asp Ser Thr Ser Ser Gly
        675                 680                 685             
Ser Glu Glu Ser Leu Lys Asp Pro Ser Met Glu Gly Asn Val Trp Phe
    690                 695                 700                 
Pro Ser Ser Thr Asp Ile Thr Ala Gln Pro Asp Val Gly Ser Gly Arg
705                 710                 715                 720 
Glu Ser Phe Leu Gln Thr Asn Tyr Thr Glu Ile Arg Val Asp Glu Ser
                725                 730                 735     
Glu Lys Thr Thr Lys Ser Phe Ser Ala Gly Pro Val Met Ser Gln Gly
            740                 745                 750         
Pro Ser Val Thr Asp Leu Glu Met Pro His Tyr Ser Thr Phe Ala Tyr
        755                 760                 765             
Phe Pro Thr Glu Val Thr Pro His Ala Phe Thr Pro Ser Ser Arg Gln
    770                 775                 780                 
Gln Asp Leu Val Ser Thr Val Asn Val Val Tyr Ser Gln Thr Thr Gln
785                 790                 795                 800 
Pro Val Tyr Asn Gly Glu Thr Pro Leu Gln Pro Ser Tyr Ser Ser Glu
                805                 810                 815     
Val Phe Pro Leu Val Thr Pro Leu Leu Leu Asp Asn Gln Ile Leu Asn
            820                 825                 830         
Thr Thr Pro Ala Ala Ser Ser Ser Asp Ser Ala Leu His Ala Thr Pro
        835                 840                 845             
Val Phe Pro Ser Val Asp Val Ser Phe Glu Ser Ile Leu Ser Ser Tyr
    850                 855                 860                 
Asp Gly Ala Pro Leu Leu Pro Phe Ser Ser Ala Ser Phe Ser Ser Glu
865                 870                 875                 880 
Leu Phe Arg His Leu His Thr Val Ser Gln Ile Leu Pro Gln Val Thr
                885                 890                 895     
Ser Ala Thr Glu Ser Asp Lys Val Pro Leu His Ala Ser Leu Pro Val
            900                 905                 910         
Ala Gly Gly Asp Leu Leu Leu Glu Pro Ser Leu Ala Gln Tyr Ser Asp
        915                 920                 925             
Val Leu Ser Thr Thr His Ala Ala Ser Glu Thr Leu Glu Phe Gly Ser
    930                 935                 940                 
Glu Ser Gly Val Leu Tyr Lys Thr Leu Met Phe Ser Gln Val Glu Pro
945                 950                 955                 960 
Pro Ser Ser Asp Ala Met Met His Ala Arg Ser Ser Gly Pro Glu Pro
                965                 970                 975     
Ser Tyr Ala Leu Ser Asp Asn Glu Gly Ser Gln His Ile Phe Thr Val
            980                 985                 990         
Ser Tyr Ser Ser Ala Ile Pro Val His Asp Ser Val Gly Val Thr Tyr
        995                 1000                1005            
Gln Gly Ser Leu Phe Ser Gly Pro Ser His Ile Pro Ile Pro Lys Ser
    1010                1015                1020                
Ser Leu Ile Thr Pro Thr Ala Ser Leu Leu Gln Pro Thr His Ala Leu
1025                1030                1035                1040
Ser Gly Asp Gly Glu Trp Ser Gly Ala Ser Ser Asp Ser Glu Phe Leu
                1045                1050                1055    
Leu Pro Asp Thr Asp Gly Leu Thr Ala Leu Asn Ile Ser Ser Pro Val
            1060                1065                1070        
Ser Val Ala Glu Phe Thr Tyr Thr Thr Ser Val Phe Gly Asp Asp Asn
        1075                1080                1085            
Lys Ala Leu Ser Lys Ser Glu Ile Ile Tyr Gly Asn Glu Thr Glu Leu
    1090                1095                1100                
Gln Ile Pro Ser Phe Asn Glu Met Val Tyr Pro Ser Glu Ser Thr Val
1105                1110                1115                1120
Met Pro Asn Met Tyr Asp Asn Val Asn Lys Leu Asn Ala Ser Leu Gln
                1125                1130                1135    
Glu Thr Ser Val Ser Ile Ser Ser Thr Lys Gly Met Phe Pro Gly Ser
            1140                1145                1150        
Leu Ala His Thr Thr Thr Lys Val Phe Asp His Glu Ile Ser Gln Val
        1155                1160                1165            
Pro Glu Asn Asn Phe Ser Val Gln Pro Thr His Thr Val Ser Gln Ala
    1170                1175                1180                
Ser Gly Asp Thr Ser Leu Lys Pro Val Leu Ser Ala Asn Ser Glu Pro
1185                1190                1195                1200
Ala Ser Ser Asp Pro Ala Ser Ser Glu Met Leu Ser Pro Ser Thr Gln
                1205                1210                1215    
Leu Leu Phe Tyr Glu Thr Ser Ala Ser Phe Ser Thr Glu Val Leu Leu
            1220                1225                1230        
Gln Pro Ser Phe Gln Ala Ser Asp Val Asp Thr Leu Leu Lys Thr Val
        1235                1240                1245            
Leu Pro Ala Val Pro Ser Asp Pro Ile Leu Val Glu Thr Pro Lys Val
    1250                1255                1260                
Asp Lys Ile Ser Ser Thr Met Leu His Leu Ile Val Ser Asn Ser Ala
1265                1270                1275                1280
Ser Ser Glu Asn Met Leu His Ser Thr Ser Val Pro Val Phe Asp Val
                1285                1290                1295    
Ser Pro Thr Ser His Met His Ser Ala Ser Leu Gln Gly Leu Thr Ile
            1300                1305                1310        
Ser Tyr Ala Ser Glu Lys Tyr Glu Pro Val Leu Leu Lys Ser Glu Ser
        1315                1320                1325            
Ser His Gln Val Val Pro Ser Leu Tyr Ser Asn Asp Glu Leu Phe Gln
    1330                1335                1340                
Thr Ala Asn Leu Glu Ile Asn Gln Ala His Pro Pro Lys Gly Arg His
1345                1350                1355                1360
Val Phe Ala Thr Pro Val Leu Ser Ile Asp Glu Pro Leu Asn Thr Leu
                1365                1370                1375    
Ile Asn Lys Leu Ile His Ser Asp Glu Ile Leu Thr Ser Thr Lys Ser
            1380                1385                1390        
Ser Val Thr Gly Lys Val Phe Ala Gly Ile Pro Thr Val Ala Ser Asp
        1395                1400                1405            
Thr Phe Val Ser Thr Asp His Ser Val Pro Ile Gly Asn Gly His Val
    1410                1415                1420                
Ala Ile Thr Ala Val Ser Pro His Arg Asp Gly Ser Val Thr Ser Thr
1425                1430                1435                1440
Lys Leu Leu Phe Pro Ser Lys Ala Thr Ser Glu Leu Ser His Ser Ala
                1445                1450                1455    
Lys Ser Asp Ala Gly Leu Val Gly Gly Gly Glu Asp Gly Asp Thr Asp
            1460                1465                1470        
Asp Asp Gly Asp Asp Asp Asp Asp Asp Arg Gly Ser Asp Gly Leu Ser
        1475                1480                1485            
Ile His Lys Cys Met Ser Cys Ser Ser Tyr Arg Glu Ser Gln Glu Lys
    1490                1495                1500                
Val Met Asn Asp Ser Asp Thr His Glu Asn Ser Leu Met Asp Gln Asn
1505                1510                1515                1520
Asn Pro Ile Ser Tyr Ser Leu Ser Glu Asn Ser Glu Glu Asp Asn Arg
                1525                1530                1535    
Val Thr Ser Val Ser Ser Asp Ser Gln Thr Gly Met Asp Arg Ser Pro
            1540                1545                1550        
Gly Lys Ser Pro Ser Ala Asn Gly Leu Ser Gln Lys His Asn Asp Gly
        1555                1560                1565            
Lys Glu Glu Asn Asp Ile Gln Thr Gly Ser Ala Leu Leu Pro Leu Ser
    1570                1575                1580                
Pro Glu Ser Lys Ala Trp Ala Val Leu Thr Ser Asp Glu Glu Ser Gly
1585                1590                1595                1600
Ser Gly Gln Gly Thr Ser Asp Ser Leu Asn Glu Asn Glu Thr Ser Thr
                1605                1610                1615    
Asp Phe Ser Phe Ala Asp Thr Asn Glu Lys Asp Ala Asp Gly Ile Leu
            1620                1625                1630        
Ala Ala Gly Asp Ser Glu Ile Thr Pro Gly Phe Pro Gln Ser Pro Thr
        1635                1640                1645            
Ser Ser Val Thr Ser Glu Asn Ser Glu Val Phe His Val Ser Glu Ala
    1650                1655                1660                
Glu Ala Ser Asn Ser Ser His Glu Ser Arg Ile Gly Leu Ala Glu Gly
1665                1670                1675                1680
Leu Glu Ser Glu Lys Lys Ala Val Ile Pro Leu Val Ile Val Ser Ala
                1685                1690                1695    
Leu Thr Phe Ile Cys Leu Val Val Leu Val Gly Ile Leu Ile Tyr Trp
            1700                1705                1710        
Arg Lys Cys Phe Gln Thr Ala His Phe Tyr Leu Glu Asp Ser Thr Ser
        1715                1720                1725            
Pro Arg Val Ile Ser Thr Pro Pro Thr Pro Ile Phe Pro Ile Ser Asp
    1730                1735                1740                
Asp Val Gly Ala Ile Pro Ile Lys His Phe Pro Lys His Val Ala Asp
1745                1750                1755                1760
Leu His Ala Ser Ser Gly Phe Thr Glu Glu Phe Glu Thr Leu Lys Glu
                1765                1770                1775    
Phe Tyr Gln Glu Val Gln Ser Cys Thr Val Asp Leu Gly Ile Thr Ala
            1780                1785                1790        
Asp Ser Ser Asn His Pro Asp Asn Lys His Lys Asn Arg Tyr Ile Asn
        1795                1800                1805            
Ile Val Ala Tyr Asp His Ser Arg Val Lys Leu Ala Gln Leu Ala Glu
    1810                1815                1820                
Lys Asp Gly Lys Leu Thr Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly
1825                1830                1835                1840
Tyr Asn Arg Pro Lys Ala Tyr Ile Ala Ala Gln Gly Pro Leu Lys Ser
                1845                1850                1855    
Thr Ala Glu Asp Phe Trp Arg Met Ile Trp Glu His Asn Val Glu Val
            1860                1865                1870        
Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys Cys Asp
        1875                1880                1885            
Gln Tyr Trp Pro Ala Asp Gly Ser Glu Glu Tyr Gly Asn Phe Leu Val
    1890                1895                1900                
Thr Gln Lys Ser Val Gln Val Leu Ala Tyr Tyr Thr Val Arg Asn Phe
1905                1910                1915                1920
Thr Leu Arg Asn Thr Lys Ile Lys Lys Gly Ser Gln Lys Gly Arg Pro
                1925                1930                1935    
Ser Gly Arg Val Val Thr Gln Tyr His Tyr Thr Gln Trp Pro Asp Met
            1940                1945                1950        
Gly Val Pro Glu Tyr Ser Leu Pro Val Leu Thr Phe Val Arg Lys Ala
        1955                1960                1965            
Ala Tyr Ala Lys Arg His Ala Val Gly Pro Val Val Val His Cys Ser
    1970                1975                1980                
Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val Leu Asp Ser Met Leu
1985                1990                1995                2000
Gln Gln Ile Gln His Glu Gly Thr Val Asn Ile Phe Gly Phe Leu Lys
                2005                2010                2015    
His Ile Arg Ser Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln Tyr
            2020                2025                2030        
Val Phe Ile His Asp Thr Leu Val Glu Ala Ile Leu Ser Lys Glu Thr
        2035                2040                2045            
Glu Val Leu Asp Ser His Ile His Ala Tyr Val Asn Ala Leu Leu Ile
    2050                2055                2060                
Pro Gly Pro Ala Gly Lys Thr Lys Leu Glu Lys Gln Phe Gln Leu Leu
2065                2070                2075                2080
Ser Gln Ser Asn Ile Gln Gln Ser Asp Tyr Ser Ala Ala Leu Lys Gln
                2085                2090                2095    
Cys Asn Arg Glu Lys Asn Arg Thr Ser Ser Ile Ile Pro Val Glu Arg
            2100                2105                2110        
Ser Arg Val Gly Ile Ser Ser Leu Ser Gly Glu Gly Thr Asp Tyr Ile
        2115                2120                2125            
Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Gln Ser Asn Glu Phe Ile Ile
    2130                2135                2140                
Thr Gln His Pro Leu Leu His Thr Ile Lys Asp Phe Trp Arg Met Ile
2145                2150                2155                2160
Trp Asp His Asn Ala Gln Leu Val Val Met Ile Pro Asp Gly Gln Asn
                2165                2170                2175    
Met Ala Glu Asp Glu Phe Val Tyr Trp Pro Asn Lys Asp Glu Pro Ile
            2180                2185                2190        
Asn Cys Glu Ser Phe Lys Val Thr Leu Met Ala Glu Glu His Lys Cys
        2195                2200                2205            
Leu Ser Asn Glu Glu Lys Leu Ile Ile Gln Asp Phe Ile Leu Glu Ala
    2210                2215                2220                
Thr Gln Asp Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys Pro Lys
2225                2230                2235                2240
Trp Pro Asn Pro Asp Ser Pro Ile Ser Lys Thr Phe Glu Leu Ile Ser
                2245                2250                2255    
Val Ile Lys Glu Glu Ala Ala Asn Arg Asp Gly Pro Met Ile Val His
            2260                2265                2270        
Asp Glu His Gly Gly Val Thr Ala Gly Thr Phe Cys Ala Leu Thr Thr
        2275                2280                2285            
Leu Met His Gln Leu Glu Lys Glu Asn Ser Val Asp Val Tyr Gln Val
    2290                2295                2300                
Ala Lys Met Ile Asn Leu Met Arg Pro Gly Val Phe Ala Asp Ile Glu
2305                2310                2315                2320
Gln Tyr Gln Phe Leu Tyr Lys Val Ile Leu Ser Leu Val Ser Thr Arg
                2325                2330                2335    
Gln Glu Glu Asn Pro Ser Thr Ser Leu Asp Ser Asn Gly Ala Ala Leu
            2340                2345                2350        
Pro Asp Gly Asn Ile Ala Glu Ser Leu Glu Ser Leu Val
        2355                2360                2365


<210> 6461
<211> 715
<212> PRT
<213> Homo sapiens

<400> 6461
Ser His Thr Arg Gly Gly Gly Leu Ser Cys Arg Arg Arg Arg Leu Cys
 1               5                  10                  15      
Arg Arg Arg Glu Cys Gly Val Gly Thr Gly Ala Ala Ala Ala Ala Thr
            20                  25                  30          
Pro Gly Ile Phe Val Ala Ser Ser Arg Pro Phe Cys Pro Ala Ala Phe
        35                  40                  45              
Pro Gln Ser Ala Leu Pro Thr Pro Leu Arg Pro Gly Ala Pro Ala Ser
    50                  55                  60                  
Ile Ser Arg Ser Leu Ser Thr Thr His Thr Ala Pro Pro Ile Met Asp
65                  70                  75                  80  
Pro Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser
                85                  90                  95      
Ser Gly Ser Ser Ser Ser Asp Ser Ala Pro Asp Cys Trp Asp Gln Ala
            100                 105                 110         
Asp Met Glu Ala Pro Gly Pro Gly Pro Cys Gly Gly Gly Gly Ser Leu
        115                 120                 125             
Ala Ala Ala Ala Glu Ala Gln Arg Glu Asn Leu Ser Ala Ala Phe Ser
    130                 135                 140                 
Arg Gln Leu Asn Val Asn Ala Lys Pro Phe Val Pro Asn Val His Ala
145                 150                 155                 160 
Ala Glu Phe Val Pro Ser Phe Leu Arg Gly Pro Ala Ala Pro Pro Pro
                165                 170                 175     
Pro Val Gly Gly Ala Ala Asn Asn His Gly Ala Gly Ser Gly Ala Gly
            180                 185                 190         
Gly Arg Ala Ala Pro Val Glu Ser Ser Gln Glu Glu Gln Ser Leu Cys
        195                 200                 205             
Glu Gly Ser Asn Ser Ala Val Ser Met Glu Leu Ser Glu Pro Ile Val
    210                 215                 220                 
Glu Asn Gly Glu Thr Glu Met Ser Pro Glu Glu Ser Trp Glu His Lys
225                 230                 235                 240 
Glu Glu Ile Ser Glu Ala Glu Pro Gly Gly Gly Ser Leu Gly Asp Gly
                245                 250                 255     
Arg Pro Pro Glu Glu Ser Ala His Glu Met Met Glu Glu Glu Glu Glu
            260                 265                 270         
Ile Pro Lys Pro Lys Ser Val Val Ala Pro Pro Gly Ala Pro Lys Lys
        275                 280                 285             
Glu His Val Asn Val Val Phe Ile Gly His Val Asp Ala Gly Lys Ser
    290                 295                 300                 
Thr Ile Gly Gly Gln Ile Met Tyr Leu Thr Gly Met Val Asp Lys Arg
305                 310                 315                 320 
Thr Leu Glu Lys Tyr Glu Arg Glu Ala Lys Glu Lys Asn Arg Glu Thr
                325                 330                 335     
Trp Tyr Leu Ser Trp Ala Leu Asp Thr Asn Gln Glu Glu Arg Asp Lys
            340                 345                 350         
Gly Lys Thr Val Glu Val Gly Arg Ala Tyr Phe Glu Thr Glu Lys Lys
        355                 360                 365             
His Phe Thr Ile Leu Asp Ala Pro Gly His Lys Ser Phe Val Pro Asn
    370                 375                 380                 
Met Ile Gly Gly Ala Ser Gln Ala Asp Leu Ala Val Leu Val Ile Ser
385                 390                 395                 400 
Ala Arg Lys Gly Glu Phe Glu Thr Gly Phe Glu Lys Gly Gly Gln Thr
                405                 410                 415     
Arg Glu His Ala Met Leu Ala Lys Thr Ala Gly Val Lys His Leu Ile
            420                 425                 430         
Val Leu Ile Asn Lys Met Asp Asp Pro Thr Val Asn Trp Ser Asn Glu
        435                 440                 445             
Arg Tyr Glu Glu Cys Lys Glu Lys Leu Val Pro Phe Leu Lys Lys Val
    450                 455                 460                 
Gly Phe Asn Pro Lys Lys Asp Ile His Phe Met Pro Cys Ser Gly Leu
465                 470                 475                 480 
Thr Gly Ala Asn Leu Lys Glu Gln Ser Asp Phe Cys Pro Trp Tyr Ile
                485                 490                 495     
Gly Leu Pro Phe Ile Pro Tyr Leu Asp Asn Leu Pro Asn Phe Asn Arg
            500                 505                 510         
Ser Val Asp Gly Pro Ile Arg Leu Pro Ile Val Asp Lys Tyr Lys Asp
        515                 520                 525             
Met Gly Thr Val Val Leu Gly Lys Leu Glu Ser Gly Ser Ile Cys Lys
    530                 535                 540                 
Gly Gln Gln Leu Val Met Met Pro Asn Lys His Asn Val Glu Val Leu
545                 550                 555                 560 
Gly Ile Leu Ser Asp Asp Val Glu Thr Asp Thr Val Ala Pro Gly Glu
                565                 570                 575     
Asn Leu Lys Ile Arg Leu Lys Gly Ile Glu Glu Glu Glu Ile Leu Pro
            580                 585                 590         
Gly Phe Ile Leu Cys Asp Pro Asn Asn Leu Cys His Ser Gly Arg Thr
        595                 600                 605             
Phe Asp Ala Gln Ile Val Ile Ile Glu His Lys Ser Ile Ile Cys Pro
    610                 615                 620                 
Gly Tyr Asn Ala Val Leu His Ile His Thr Cys Ile Glu Glu Val Glu
625                 630                 635                 640 
Ile Thr Ala Leu Ile Cys Leu Val Asp Lys Lys Ser Gly Glu Lys Ser
                645                 650                 655     
Lys Thr Arg Pro Arg Phe Val Lys Gln Asp Gln Val Cys Ile Ala Arg
            660                 665                 670         
Leu Arg Thr Ala Gly Thr Ile Cys Leu Glu Thr Phe Lys Asp Phe Pro
        675                 680                 685             
Gln Met Gly Arg Phe Thr Leu Arg Asp Glu Gly Lys Thr Ile Ala Ile
    690                 695                 700                 
Gly Lys Val Leu Lys Leu Val Pro Glu Lys Asp
705                 710                 715 


<210> 6462
<211> 712
<212> PRT
<213> Homo sapiens

<400> 6462
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Pro Leu Pro Thr Gln Pro
    370                 375                 380                 
Ala Thr Leu Gly Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly
385                 390                 395                 400 
Cys Glu Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu
                405                 410                 415     
Val Asn Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser
            420                 425                 430         
Ser Lys Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly
        435                 440                 445             
Val Leu Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln
    450                 455                 460                 
Cys Val Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys
465                 470                 475                 480 
Pro Gln Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr
                485                 490                 495     
Leu Arg Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr
            500                 505                 510         
Leu Val Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu
        515                 520                 525             
Arg Gly Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys
    530                 535                 540                 
Cys Cys Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn
545                 550                 555                 560 
Ala Tyr Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala
                565                 570                 575     
Lys Asn Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val
            580                 585                 590         
Leu Asp Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val
        595                 600                 605             
Val Gly Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile
    610                 615                 620                 
Pro Gly Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp
625                 630                 635                 640 
Leu Pro Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly
                645                 650                 655     
Phe Phe Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe
            660                 665                 670         
Leu Glu Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr
        675                 680                 685             
Met Ser Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro
    690                 695                 700                 
Pro Asp Asn Lys Lys Arg Lys Lys
705                 710         


<210> 6463
<211> 710
<212> PRT
<213> Homo sapiens

<400> 6463
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Ser
    130                 135                 140                 
Ser Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Ile Val Leu Ala Val Leu Glu
305                 310                 315                 320 
Ala Ile Leu Leu Leu Val Leu Ile Phe Leu Arg Gln Arg Ile Arg Ile
                325                 330                 335     
Ala Ile Ala Leu Leu Lys Glu Ala Ser Lys Ala Val Gly Gln Met Met
            340                 345                 350         
Ser Thr Met Phe Tyr Pro Leu Val Thr Phe Val Leu Leu Leu Ile Cys
        355                 360                 365             
Ile Ala Tyr Trp Ala Met Thr Ala Leu Tyr Leu Ala Thr Ser Gly Gln
    370                 375                 380                 
Pro Gln Tyr Val Leu Trp Ala Ser Asn Ile Ser Ser Pro Gly Cys Glu
385                 390                 395                 400 
Lys Val Pro Ile Asn Thr Ser Cys Asn Pro Thr Ala His Leu Val Asn
                405                 410                 415     
Ser Ser Cys Pro Gly Leu Met Cys Val Phe Gln Gly Tyr Ser Ser Lys
            420                 425                 430         
Gly Leu Ile Gln Arg Ser Val Phe Asn Leu Gln Ile Tyr Gly Val Leu
        435                 440                 445             
Gly Leu Phe Trp Thr Leu Asn Trp Val Leu Ala Leu Gly Gln Cys Val
    450                 455                 460                 
Leu Ala Gly Ala Phe Ala Ser Phe Tyr Trp Ala Phe His Lys Pro Gln
465                 470                 475                 480 
Asp Ile Pro Thr Phe Pro Leu Ile Ser Ala Phe Ile Arg Thr Leu Arg
                485                 490                 495     
Tyr His Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Thr Leu Val
            500                 505                 510         
Gln Ile Ala Arg Val Ile Leu Glu Tyr Ile Asp His Lys Leu Arg Gly
        515                 520                 525             
Val Gln Asn Pro Val Ala Arg Cys Ile Met Cys Cys Phe Lys Cys Cys
    530                 535                 540                 
Leu Trp Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr
545                 550                 555                 560 
Ile Met Ile Ala Ile Tyr Gly Lys Asn Phe Cys Val Ser Ala Lys Asn
                565                 570                 575     
Ala Phe Met Leu Leu Met Arg Asn Ile Val Arg Val Val Val Leu Asp
            580                 585                 590         
Lys Val Thr Asp Leu Leu Leu Phe Phe Gly Lys Leu Leu Val Val Gly
        595                 600                 605             
Gly Val Gly Val Leu Ser Phe Phe Phe Phe Ser Gly Arg Ile Pro Gly
    610                 615                 620                 
Leu Gly Lys Asp Phe Lys Ser Pro His Leu Asn Tyr Tyr Trp Leu Pro
625                 630                 635                 640 
Ile Met Thr Ser Ile Leu Gly Ala Tyr Val Ile Ala Ser Gly Phe Phe
                645                 650                 655     
Ser Val Phe Gly Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu
            660                 665                 670         
Asp Leu Glu Arg Asn Asn Gly Ser Leu Asp Arg Pro Tyr Tyr Met Ser
        675                 680                 685             
Lys Ser Leu Leu Lys Ile Leu Gly Lys Lys Asn Glu Ala Pro Pro Asp
    690                 695                 700                 
Asn Lys Lys Arg Lys Lys
705                 710 


<210> 6464
<211> 338
<212> PRT
<213> Homo sapiens

<400> 6464
Met Gly Gly Lys Gln Arg Asp Glu Asp Asp Glu Ala Tyr Gly Lys Pro
 1               5                  10                  15      
Val Lys Tyr Asp Pro Ser Phe Arg Gly Pro Ile Lys Asn Arg Ser Cys
            20                  25                  30          
Thr Asp Val Ile Cys Cys Val Leu Phe Leu Leu Phe Ile Leu Gly Tyr
        35                  40                  45              
Ile Val Val Gly Ile Val Ala Trp Leu Tyr Gly Asp Pro Arg Gln Val
    50                  55                  60                  
Leu Tyr Pro Arg Asn Ser Thr Gly Ala Tyr Cys Gly Met Gly Glu Asn
65                  70                  75                  80  
Lys Asp Lys Pro Tyr Leu Leu Tyr Phe Asn Ile Phe Ser Cys Ile Leu
                85                  90                  95      
Ser Ser Asn Ile Ile Ser Val Ala Glu Asn Gly Leu Gln Cys Pro Thr
            100                 105                 110         
Pro Gln Val Cys Val Ser Ser Cys Pro Glu Asp Pro Trp Thr Val Gly
        115                 120                 125             
Lys Asn Glu Phe Ser Gln Thr Val Gly Glu Val Phe Tyr Thr Lys Asn
    130                 135                 140                 
Arg Asn Phe Cys Leu Pro Gly Val Pro Trp Asn Met Thr Val Ile Thr
145                 150                 155                 160 
Ser Leu Gln Gln Glu Leu Cys Pro Ser Phe Leu Leu Pro Ser Ala Pro
                165                 170                 175     
Ala Leu Gly Arg Cys Phe Pro Trp Thr Asn Ile Thr Pro Pro Ala Leu
            180                 185                 190         
Pro Gly Ile Thr Asn Asp Thr Thr Ile Gln Gln Gly Ile Ser Gly Leu
        195                 200                 205             
Ile Asp Ser Leu Asn Ala Arg Asp Ile Ser Val Lys Ile Phe Glu Asp
    210                 215                 220                 
Phe Ala Gln Ser Trp Tyr Trp Ile Leu Val Ala Leu Gly Val Ala Leu
225                 230                 235                 240 
Val Leu Ser Leu Leu Phe Ile Leu Leu Leu Arg Leu Val Ala Gly Pro
                245                 250                 255     
Leu Val Leu Val Leu Ile Leu Gly Val Leu Gly Val Leu Ala Tyr Gly
            260                 265                 270         
Ile Tyr Tyr Cys Trp Glu Glu Tyr Arg Val Leu Arg Asp Lys Gly Ala
        275                 280                 285             
Ser Ile Ser Gln Leu Gly Phe Thr Thr Asn Leu Ser Ala Tyr Gln Ser
    290                 295                 300                 
Val Gln Glu Thr Trp Leu Ala Ala Leu Cys Pro His Leu Arg Ile Leu
305                 310                 315                 320 
Ser Phe His Met Ala Lys Cys Gly Pro Thr Thr Leu Ser Ala Leu Pro
                325                 330                 335     
Gly His
        


<210> 6465
<211> 752
<212> PRT
<213> Homo sapiens

<400> 6465
Met Tyr Thr Gly Pro Cys Lys Val Leu His Leu Ser Ser Gly Leu Leu
 1               5                  10                  15      
Pro Asn Ser Gly Arg Phe Gly Ile Val Leu Ser Asp Glu Tyr Gln Val
            20                  25                  30          
Val Thr Ser Leu Trp Cys Gln Leu Tyr Thr Thr His Ala Pro Gln Gln
        35                  40                  45              
Ala Ser Gly Met Leu Leu Leu Asn Tyr Leu Val Ile Pro Ser Lys Ala
    50                  55                  60                  
Gln Val Asn Lys Pro Gly Tyr Ile Pro Asn Leu Gly Glu Cys Ser His
65                  70                  75                  80  
Tyr Arg Ser Lys Ile His Leu Lys Ala Gly Asp Lys Leu Gln Ser Pro
                85                  90                  95      
Glu Gly Lys Pro Lys Thr Gly Arg Ile Gln Glu Lys Cys Glu Gly Pro
            100                 105                 110         
Cys Ile Ser Ser Ser Asn Cys Ser Gln Pro Cys Ala Lys Asp Phe His
        115                 120                 125             
Gly Glu Ile Gly Phe Thr Cys Asn Gln Lys Lys Trp Gln Lys Ser Ala
    130                 135                 140                 
Glu Thr Cys Thr Ser Leu Ser Val Glu Lys Leu Phe Lys Asp Ser Thr
145                 150                 155                 160 
Gly Ala Ser Arg Leu Ser Val Ala Ala Pro Ser Ile Pro Leu His Ile
                165                 170                 175     
Leu Asp Phe Arg Ala Pro Glu Thr Ile Glu Ser Val Ala Gln Gly Ile
            180                 185                 190         
Arg Lys Asn Cys Pro Phe Asp Tyr Ala Cys Ile Thr Asp Met Val Lys
        195                 200                 205             
Ser Ser Glu Thr Thr Ser Gly Asn Ile Ala Phe Ile Val Glu Leu Leu
    210                 215                 220                 
Lys Asn Ile Ser Thr Asp Leu Ser Asp Asn Val Thr Arg Glu Lys Met
225                 230                 235                 240 
Lys Ser Tyr Ser Glu Val Ala Asn His Ile Leu Asp Thr Ala Ala Ile
                245                 250                 255     
Ser Asn Trp Ala Phe Ile Pro Asn Lys Asn Ala Ser Ser Asp Leu Leu
            260                 265                 270         
Gln Ser Val Asn Leu Phe Ala Arg Gln Leu His Ile His Asn Asn Ser
        275                 280                 285             
Glu Asn Ile Val Asn Glu Leu Phe Ile Gln Thr Lys Gly Phe His Ile
    290                 295                 300                 
Asn His Asn Thr Ser Glu Lys Ser Leu Asn Phe Ser Met Ser Met Asn
305                 310                 315                 320 
Asn Thr Thr Glu Asp Ile Leu Gly Met Val Gln Ile Pro Arg Gln Glu
                325                 330                 335     
Leu Arg Lys Leu Trp Pro Asn Ala Ser Gln Ala Ile Ser Ile Ala Phe
            340                 345                 350         
Pro Thr Leu Gly Ala Ile Leu Arg Glu Ala His Leu Gln Asn Val Ser
        355                 360                 365             
Leu Pro Arg Gln Val Asn Gly Leu Val Leu Ser Val Val Leu Pro Glu
    370                 375                 380                 
Arg Leu Gln Glu Ile Ile Leu Thr Phe Glu Lys Ile Asn Lys Thr Arg
385                 390                 395                 400 
Asn Ala Arg Ala Gln Cys Val Gly Trp His Ser Lys Lys Arg Arg Trp
                405                 410                 415     
Asp Glu Lys Ala Cys Gln Met Met Leu Asp Ile Arg Asn Glu Val Lys
            420                 425                 430         
Cys Arg Cys Asn Tyr Thr Ser Val Val Met Ser Phe Ser Ile Leu Met
        435                 440                 445             
Ser Ser Lys Ser Met Thr Asp Lys Val Leu Asp Tyr Ile Thr Cys Ile
    450                 455                 460                 
Gly Leu Ser Val Ser Ile Leu Ser Leu Val Leu Cys Leu Ile Ile Glu
465                 470                 475                 480 
Ala Thr Val Trp Ser Arg Val Val Val Thr Glu Ile Ser Tyr Met Arg
                485                 490                 495     
His Val Cys Ile Val Asn Ile Ala Val Ser Leu Leu Thr Ala Asn Val
            500                 505                 510         
Trp Phe Ile Ile Gly Ser His Phe Asn Ile Lys Ala Gln Asp Tyr Asn
        515                 520                 525             
Met Cys Val Ala Val Thr Phe Phe Ser His Phe Phe Tyr Leu Ser Leu
    530                 535                 540                 
Phe Phe Trp Met Leu Phe Lys Ala Leu Leu Ile Ile Tyr Gly Ile Leu
545                 550                 555                 560 
Val Ile Phe Arg Arg Met Met Lys Ser Arg Met Met Val Ile Gly Phe
                565                 570                 575     
Ala Ile Gly Tyr Gly Cys Pro Leu Ile Ile Ala Val Thr Thr Val Ala
            580                 585                 590         
Ile Thr Glu Pro Glu Lys Gly Tyr Met Arg Pro Glu Ala Cys Trp Leu
        595                 600                 605             
Asn Trp Asp Asn Thr Lys Ala Leu Leu Ala Phe Ala Ile Pro Ala Phe
    610                 615                 620                 
Val Ile Val Ala Val Asn Leu Ile Val Val Leu Val Val Ala Val Asn
625                 630                 635                 640 
Thr Gln Arg Pro Ser Ile Gly Ser Ser Lys Ser Gln Asp Val Val Ile
                645                 650                 655     
Ile Met Arg Ile Ser Lys Asn Val Ala Ile Leu Thr Pro Leu Leu Gly
            660                 665                 670         
Leu Thr Trp Gly Phe Gly Ile Ala Thr Leu Ile Glu Gly Thr Ser Leu
        675                 680                 685             
Thr Phe His Ile Ile Phe Ala Leu Leu Asn Ala Phe Gln Gly Phe Phe
    690                 695                 700                 
Ile Leu Leu Phe Gly Thr Ile Met Asp His Lys Ile Arg Asp Ala Leu
705                 710                 715                 720 
Arg Met Arg Met Ser Ser Leu Lys Gly Lys Ser Arg Ala Ala Glu Asn
                725                 730                 735     
Ala Ser Leu Gly Pro Thr Asn Gly Ser Lys Leu Met Asn Arg Gln Gly
            740                 745                 750         


<210> 6466
<211> 469
<212> PRT
<213> Homo sapiens

<400> 6466
Ser Pro Gly Ala Gly Ser Arg Arg Arg Val Ala Gly Ala Pro Ala Pro
 1               5                  10                  15      
Trp Ala Ala Ala His Gly Gly Ala Met Met Asp Val Asn Ser Ser Gly
            20                  25                  30          
Arg Pro Asp Leu Tyr Gly His Leu Arg Ser Phe Leu Leu Pro Glu Val
        35                  40                  45              
Gly Arg Gly Leu Pro Asp Leu Ser Pro Asp Gly Gly Ala Asp Pro Val
    50                  55                  60                  
Ala Gly Ser Trp Ala Pro His Leu Leu Ser Glu Val Thr Ala Ser Pro
65                  70                  75                  80  
Ala Pro Thr Trp Asp Ala Pro Pro Asp Asn Ala Ser Gly Cys Gly Glu
                85                  90                  95      
Gln Ile Asn Tyr Gly Arg Val Glu Lys Val Val Ile Gly Ser Ile Leu
            100                 105                 110         
Thr Leu Ile Thr Leu Leu Thr Ile Ala Gly Asn Cys Leu Val Val Ile
        115                 120                 125             
Ser Val Cys Phe Val Lys Lys Leu Arg Gln Pro Ser Asn Tyr Leu Ile
    130                 135                 140                 
Val Ser Leu Ala Leu Ala Asp Leu Ser Val Ala Val Ala Val Met Pro
145                 150                 155                 160 
Phe Val Ser Val Thr Asp Leu Ile Gly Gly Lys Trp Ile Phe Gly His
                165                 170                 175     
Phe Phe Cys Asn Val Phe Ile Ala Met Asp Val Met Cys Cys Thr Ala
            180                 185                 190         
Ser Ile Met Thr Leu Cys Val Ile Ser Ile Asp Arg Tyr Leu Gly Ile
        195                 200                 205             
Thr Arg Pro Leu Thr Tyr Pro Val Arg Gln Asn Gly Lys Cys Met Ala
    210                 215                 220                 
Lys Met Ile Leu Ser Val Trp Leu Leu Ser Ala Ser Ile Thr Leu Pro
225                 230                 235                 240 
Pro Leu Phe Gly Trp Ala Gln Asn Val Asn Asp Asp Lys Val Cys Leu
                245                 250                 255     
Ile Ser Gln Asp Phe Gly Tyr Thr Ile Tyr Ser Thr Ala Val Ala Phe
            260                 265                 270         
Tyr Ile Pro Met Ser Val Met Leu Phe Met Tyr Tyr Gln Ile Tyr Lys
        275                 280                 285             
Ala Ala Arg Lys Ser Ala Ala Lys His Lys Phe Pro Gly Phe Pro Arg
    290                 295                 300                 
Val Glu Pro Asp Ser Val Ile Ala Leu Asn Gly Ile Val Lys Leu Gln
305                 310                 315                 320 
Lys Glu Val Glu Glu Cys Ala Asn Leu Ser Arg Leu Leu Lys His Glu
                325                 330                 335     
Arg Lys Asn Ile Ser Ile Phe Lys Arg Glu Gln Lys Ala Ala Thr Thr
            340                 345                 350         
Leu Gly Ile Ile Val Gly Ala Phe Thr Val Cys Trp Leu Pro Phe Phe
        355                 360                 365             
Leu Leu Ser Thr Ala Arg Pro Phe Ile Cys Gly Thr Ser Cys Ser Cys
    370                 375                 380                 
Ile Pro Leu Trp Val Glu Arg Thr Phe Leu Trp Leu Gly Tyr Ala Asn
385                 390                 395                 400 
Ser Leu Ile Asn Pro Phe Ile Tyr Ala Phe Phe Asn Arg Asp Leu Arg
                405                 410                 415     
Thr Thr Tyr Arg Ser Leu Leu Gln Cys Gln Tyr Arg Asn Ile Asn Arg
            420                 425                 430         
Lys Leu Ser Ala Ala Gly Met His Glu Ala Leu Lys Leu Ala Glu Arg
        435                 440                 445             
Pro Glu Arg Pro Glu Phe Val Leu Gln Asn Ala Asp Tyr Cys Arg Lys
    450                 455                 460                 
Lys Gly His Asp Ser
465                 


<210> 6467
<211> 253
<212> PRT
<213> Homo sapiens

<400> 6467
Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp
 1               5                  10                  15      
Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn
            20                  25                  30          
Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg
        35                  40                  45              
Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly
    50                  55                  60                  
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly
65                  70                  75                  80  
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His
                85                  90                  95      
Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met
            100                 105                 110         
Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr
        115                 120                 125             
Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp
    130                 135                 140                 
Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln
145                 150                 155                 160 
Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val
                165                 170                 175     
His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr
            180                 185                 190         
Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg
        195                 200                 205             
Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala
    210                 215                 220                 
Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val
225                 230                 235                 240 
Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly
                245                 250             


<210> 6468
<211> 285
<212> PRT
<213> Homo sapiens

<400> 6468
Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp
 1               5                  10                  15      
Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn
            20                  25                  30          
Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg
        35                  40                  45              
Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly
    50                  55                  60                  
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly
65                  70                  75                  80  
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly
                85                  90                  95      
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly
            100                 105                 110         
Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His
        115                 120                 125             
Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met
    130                 135                 140                 
Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr
145                 150                 155                 160 
Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp
                165                 170                 175     
Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln
            180                 185                 190         
Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val
        195                 200                 205             
His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr
    210                 215                 220                 
Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg
225                 230                 235                 240 
Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala
                245                 250                 255     
Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val
            260                 265                 270         
Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly
        275                 280                 285 


<210> 6469
<211> 352
<212> PRT
<213> Homo sapiens

<400> 6469
Met Thr Ser Gln Glu Arg Asp Thr Ala Ile Tyr Ser Ile Asn Val Ser
 1               5                  10                  15      
Phe Val Ala Lys Gly Met Thr Ser Arg Ser Val Cys Glu Lys Met Thr
            20                  25                  30          
Met Thr Thr Glu Asn Pro Asn Gln Thr Val Val Ser His Phe Phe Leu
        35                  40                  45              
Glu Gly Leu Arg Tyr Thr Ala Lys His Ser Ser Leu Phe Phe Leu Leu
    50                  55                  60                  
Phe Leu Leu Ile Tyr Ser Ile Thr Val Ala Gly Asn Leu Leu Ile Leu
65                  70                  75                  80  
Leu Thr Val Gly Ser Asp Ser His Leu Ser Leu Pro Met Tyr His Phe
                85                  90                  95      
Leu Gly His Leu Ser Phe Leu Asp Ala Cys Leu Ser Thr Val Thr Val
            100                 105                 110         
Pro Lys Val Met Ala Gly Leu Leu Thr Leu Asp Gly Lys Val Ile Ser
        115                 120                 125             
Phe Glu Gly Cys Ala Val Gln Leu Tyr Cys Phe His Phe Leu Ala Ser
    130                 135                 140                 
Thr Glu Cys Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Tyr Leu Ala
145                 150                 155                 160 
Ile Cys Gln Pro Leu His Tyr Pro Val Ala Met Asn Arg Arg Met Cys
                165                 170                 175     
Ala Glu Met Ala Gly Ile Thr Trp Ala Ile Gly Ala Thr His Ala Ala
            180                 185                 190         
Ile His Thr Ser Leu Thr Phe Arg Leu Leu Tyr Cys Gly Pro Cys His
        195                 200                 205             
Ile Ala Tyr Phe Phe Cys Asp Ile Pro Pro Val Leu Lys Leu Ala Cys
    210                 215                 220                 
Thr Asp Thr Thr Ile Asn Glu Leu Val Met Leu Ala Ser Ile Gly Ile
225                 230                 235                 240 
Val Ala Ala Gly Cys Leu Ile Leu Ile Val Ile Ser Tyr Ile Phe Ile
                245                 250                 255     
Val Ala Ala Val Leu Arg Ile Arg Thr Ala Gln Gly Arg Gln Arg Ala
            260                 265                 270         
Phe Ser Pro Cys Thr Ala Gln Leu Thr Gly Val Leu Leu Tyr Tyr Val
        275                 280                 285             
Pro Pro Val Cys Ile Tyr Leu Gln Pro Arg Ser Ser Glu Ala Gly Ala
    290                 295                 300                 
Gly Ala Pro Ala Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro
305                 310                 315                 320 
Phe Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys His Ala Leu Gln Arg
                325                 330                 335     
Leu Leu Cys Ser Ser Phe Arg Glu Ser Thr Ala Gly Ser Pro Pro Pro
            340                 345                 350         


<210> 6470
<211> 1095
<212> PRT
<213> Homo sapiens

<400> 6470
Met Pro Leu Met Met Ser Glu Glu Gly Phe Glu Asn Glu Glu Ser Asp
 1               5                  10                  15      
Tyr His Thr Leu Pro Arg Ala Arg Ile Met Gln Arg Lys Arg Gly Leu
            20                  25                  30          
Glu Trp Phe Val Cys Asp Gly Trp Lys Phe Leu Cys Thr Ser Cys Cys
        35                  40                  45              
Gly Trp Leu Ile Asn Ile Cys Arg Arg Lys Lys Glu Leu Lys Ala Arg
    50                  55                  60                  
Thr Val Trp Leu Gly Cys Pro Glu Lys Cys Glu Glu Lys His Pro Arg
65                  70                  75                  80  
Asn Ser Ile Lys Asn Gln Lys Tyr Asn Val Phe Thr Phe Ile Pro Gly
                85                  90                  95      
Val Leu Tyr Glu Gln Phe Lys Phe Phe Leu Asn Leu Tyr Phe Leu Val
            100                 105                 110         
Ile Ser Cys Ser Gln Phe Val Pro Ala Leu Lys Ile Gly Tyr Leu Tyr
        115                 120                 125             
Thr Tyr Trp Ala Pro Leu Gly Phe Val Leu Ala Val Thr Met Thr Arg
    130                 135                 140                 
Glu Ala Ile Asp Glu Phe Arg Arg Phe Gln Arg Asp Lys Glu Val Asn
145                 150                 155                 160 
Ser Gln Leu Tyr Ser Lys Leu Thr Val Arg Gly Lys Val Gln Val Lys
                165                 170                 175     
Ser Ser Asp Ile Gln Val Gly Asp Leu Ile Ile Val Glu Lys Asn Gln
            180                 185                 190         
Arg Ile Pro Ser Asp Met Val Phe Leu Arg Thr Ser Glu Lys Ala Gly
        195                 200                 205             
Ser Cys Phe Ile Arg Thr Asp Gln Leu Asp Gly Glu Thr Asp Trp Lys
    210                 215                 220                 
Leu Lys Val Ala Val Ser Cys Thr Gln Gln Leu Pro Ala Leu Gly Asp
225                 230                 235                 240 
Leu Phe Ser Ile Ser Ala Tyr Val Tyr Ala Gln Lys Pro Gln Met Asp
                245                 250                 255     
Ile His Ser Phe Glu Gly Thr Phe Thr Arg Glu Asp Ser Asp Pro Pro
            260                 265                 270         
Ile His Glu Ser Leu Ser Ile Glu Asn Thr Leu Trp Ala Ser Thr Ile
        275                 280                 285             
Val Ala Ser Gly Thr Val Ile Gly Val Val Ile Tyr Thr Gly Lys Glu
    290                 295                 300                 
Thr Arg Ser Val Met Asn Thr Ser Asn Pro Lys Asn Lys Val Gly Leu
305                 310                 315                 320 
Leu Asp Leu Glu Leu Asn Arg Leu Thr Lys Ala Leu Phe Leu Ala Leu
                325                 330                 335     
Val Ala Leu Ser Ile Val Met Val Thr Leu Gln Gly Phe Val Gly Pro
            340                 345                 350         
Trp Tyr Arg Asn Leu Phe Arg Phe Leu Leu Leu Phe Ser Tyr Ile Ile
        355                 360                 365             
Pro Ile Ser Leu Arg Val Asn Leu Asp Met Gly Lys Ala Val Tyr Gly
    370                 375                 380                 
Trp Met Met Met Lys Asp Glu Asn Ile Pro Gly Thr Val Val Arg Thr
385                 390                 395                 400 
Ser Thr Ile Pro Glu Glu Leu Gly Arg Leu Val Tyr Leu Leu Thr Asp
                405                 410                 415     
Lys Thr Gly Thr Leu Thr Gln Asn Glu Met Ile Phe Lys Arg Leu His
            420                 425                 430         
Leu Gly Thr Val Ser Tyr Gly Ala Asp Thr Met Asp Glu Ile Gln Ser
        435                 440                 445             
His Val Arg Asp Ser Tyr Ser Gln Met Gln Ser Gln Ala Gly Gly Asn
    450                 455                 460                 
Asn Thr Gly Ser Thr Pro Leu Arg Lys Ala Gln Ser Ser Ala Pro Lys
465                 470                 475                 480 
Val Arg Lys Ser Val Ser Ser Arg Ile His Glu Ala Val Lys Ala Ile
                485                 490                 495     
Val Leu Cys His Asn Val Thr Pro Val Tyr Glu Ser Arg Ala Gly Val
            500                 505                 510         
Thr Glu Glu Thr Glu Phe Ala Glu Ala Asp Gln Asp Phe Ser Asp Glu
        515                 520                 525             
Asn Arg Thr Tyr Gln Ala Ser Ser Pro Asp Glu Val Ala Leu Val Gln
    530                 535                 540                 
Trp Thr Glu Ser Val Gly Leu Thr Leu Val Ser Arg Asp Leu Thr Ser
545                 550                 555                 560 
Met Gln Leu Lys Thr Pro Ser Gly Gln Val Leu Ser Phe Cys Ile Leu
                565                 570                 575     
Gln Leu Phe Pro Phe Thr Ser Glu Ser Lys Arg Met Gly Val Ile Val
            580                 585                 590         
Arg Asp Glu Ser Thr Ala Glu Ile Thr Phe Tyr Met Lys Gly Ala Asp
        595                 600                 605             
Val Ala Met Ser Pro Ile Val Gln Tyr Asn Asp Trp Leu Glu Glu Glu
    610                 615                 620                 
Cys Gly Asn Met Ala Arg Glu Gly Leu Arg Thr Leu Val Val Ala Lys
625                 630                 635                 640 
Lys Ala Leu Thr Glu Glu Gln Tyr Gln Asp Phe Glu Ser Arg Tyr Thr
                645                 650                 655     
Gln Ala Lys Leu Ser Met His Asp Arg Ser Leu Lys Val Ala Ala Val
            660                 665                 670         
Val Glu Ser Leu Glu Arg Glu Met Glu Leu Leu Cys Leu Thr Gly Val
        675                 680                 685             
Glu Asp Gln Leu Gln Ala Asp Val Arg Pro Thr Leu Glu Met Leu Arg
    690                 695                 700                 
Asn Ala Gly Ile Lys Ile Trp Met Leu Thr Gly Asp Lys Leu Glu Thr
705                 710                 715                 720 
Ala Thr Cys Ile Ala Lys Ser Ser His Leu Val Ser Arg Thr Gln Asp
                725                 730                 735     
Ile His Ile Phe Arg Gln Val Thr Ser Arg Gly Glu Ala His Leu Glu
            740                 745                 750         
Leu Asn Ala Phe Arg Arg Lys His Asp Cys Ala Leu Val Ile Ser Gly
        755                 760                 765             
Asp Ser Leu Glu Val Cys Leu Lys Tyr Tyr Glu His Glu Phe Val Glu
    770                 775                 780                 
Leu Ala Cys Gln Cys Pro Ala Val Val Cys Cys Arg Cys Ser Pro Thr
785                 790                 795                 800 
Gln Lys Ala Arg Ile Val Thr Leu Leu Gln Gln His Thr Gly Arg Arg
                805                 810                 815     
Thr Cys Ala Ile Gly Asp Gly Gly Asn Asp Val Ser Met Ile Gln Ala
            820                 825                 830         
Ala Asp Cys Gly Ile Gly Ile Glu Gly Lys Glu Gly Lys Gln Ala Ser
        835                 840                 845             
Leu Ala Ala Asp Phe Ser Ile Thr Gln Phe Arg His Ile Gly Arg Leu
    850                 855                 860                 
Leu Met Val His Gly Arg Asn Ser Tyr Lys Arg Ser Ala Ala Leu Gly
865                 870                 875                 880 
Gln Phe Val Met His Arg Gly Leu Ile Ile Ser Thr Met Gln Ala Val
                885                 890                 895     
Phe Ser Ser Val Phe Tyr Phe Ala Ser Val Pro Leu Tyr Gln Gly Phe
            900                 905                 910         
Leu Met Val Gly Tyr Ala Thr Ile Tyr Thr Met Phe Pro Val Phe Ser
        915                 920                 925             
Leu Val Leu Asp Gln Asp Val Lys Pro Glu Met Ala Met Leu Tyr Pro
    930                 935                 940                 
Glu Leu Tyr Lys Asp Leu Thr Lys Gly Arg Ser Leu Ser Phe Lys Thr
945                 950                 955                 960 
Phe Leu Ile Trp Val Leu Ile Ser Ile Tyr Gln Gly Gly Ile Leu Met
                965                 970                 975     
Tyr Gly Ala Leu Val Leu Phe Glu Ser Glu Phe Val His Val Val Ala
            980                 985                 990         
Ile Ser Phe Thr Ala Leu Ile Leu Thr Glu Leu Leu Met Val Ala Leu
        995                 1000                1005            
Thr Val Arg Thr Trp His Trp Leu Met Val Val Ala Glu Phe Leu Ser
    1010                1015                1020                
Leu Gly Cys Tyr Val Ser Ser Leu Ala Phe Leu Asn Glu Tyr Phe Gly
1025                1030                1035                1040
Ile Gly Arg Val Ser Phe Gly Ala Phe Leu Asp Val Ala Phe Ile Thr
                1045                1050                1055    
Thr Val Thr Phe Leu Trp Lys Val Ser Ala Ile Thr Val Val Ser Cys
            1060                1065                1070        
Leu Pro Leu Tyr Val Leu Lys Tyr Leu Arg Arg Lys Leu Ser Pro Pro
        1075                1080                1085            
Ser Tyr Cys Lys Leu Ala Ser
    1090                1095


<210> 6471
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6471
Met Ala Arg Gly Pro Gly Pro Leu Gly Arg Pro Arg Pro Asp Thr Val
 1               5                  10                  15      
Ala Met Pro Lys Arg Gly Lys Arg Leu Lys Phe Arg Ala His Asp Ala
            20                  25                  30          
Cys Ser Gly Arg Val Thr Val Ala Asp Tyr Ala Asn Ser Asp Pro Ala
        35                  40                  45              
Val Val Arg Ser Gly Arg Val Lys Lys Ala Val Ala Asn Ala Val Gln
    50                  55                  60                  
Gln Glu Val Lys Ser Leu Cys Gly Leu Glu Ala Ser Gln Val Pro Thr
65                  70                  75                  80  
Glu Glu Ala Leu Ser Gly Ala Gly Glu Pro Cys Asp Ile Ile Asp Ser
                85                  90                  95      
Ser Asp Glu Met Asp Ala Gln Glu Glu Ser Ile His Glu Arg Thr Val
            100                 105                 110         
Ser Arg Lys Lys Lys Ser Lys Arg His Lys Glu Glu Leu Asp Gly Ala
        115                 120                 125             
Gly Gly Glu Glu Tyr Pro Met Asp Ile Trp Leu Leu Leu Ala Ser Tyr
    130                 135                 140                 
Ile Arg Pro Glu Asp Ile Val Asn Phe Ser Leu Ile Cys Lys Asn Ala
145                 150                 155                 160 
Trp Thr Val Thr Cys Thr Ala Ala Phe Trp Thr Arg Leu Tyr Arg Arg
                165                 170                 175     
His Tyr Thr Leu Asp Ala Ser Leu Pro Leu Arg Leu Arg Pro Glu Ser
            180                 185                 190         
Met Glu Lys Leu Arg Cys Leu Arg Ala Cys Val Ile Arg Ser Leu Tyr
        195                 200                 205             
His Met Tyr Glu Pro Phe Ala Ala Arg Ile Ser Lys Asn Pro Ala Ile
    210                 215                 220                 
Pro Glu Ser Thr Pro Ser Thr Leu Lys Asn Ser Lys Cys Leu Leu Phe
225                 230                 235                 240 
Trp Cys Arg Lys Ile Val Gly Asn Arg Gln Glu Pro Met Trp Glu Phe
                245                 250                 255     
Asn Phe Lys Phe Lys Lys Gln Ser Pro Arg Leu Lys Ser Lys Cys Thr
            260                 265                 270         
Gly Gly Leu Gln Pro Pro Val Gln Tyr Glu Asp Val His Thr Asn Pro
        275                 280                 285             
Asp Gln Asp Cys Cys Leu Leu Gln Val Thr Thr Leu Asn Phe Ile Phe
    290                 295                 300                 
Ile Pro Ile Val Met Gly Met Ile Phe Thr Leu Phe Thr Ile Asn Val
305                 310                 315                 320 
Ser Thr Asp Met Arg His His Arg Val Arg Leu Val Phe Gln Asp Ser
                325                 330                 335     
Pro Val His Gly Gly Arg Lys Leu Arg Ser Glu Gln Gly Val Gln Val
            340                 345                 350         
Ile Leu Asp Pro Val His Ser Val Arg Leu Phe Asp Trp Trp His Pro
        355                 360                 365             
Gln Tyr Pro Phe Ser Leu Arg Ala
    370                 375     


<210> 6472
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6472
Met Ala Arg Gly Pro Gly Pro Leu Gly Arg Pro Arg Pro Asp Thr Val
 1               5                  10                  15      
Ala Met Pro Lys Arg Gly Lys Arg Leu Lys Phe Arg Ala His Asp Ala
            20                  25                  30          
Cys Ser Gly Arg Val Thr Val Ala Asp Tyr Ala Asp Ser Asp Leu Ala
        35                  40                  45              
Val Val Arg Ser Gly Arg Val Lys Lys Ala Val Ala Asn Ala Val Arg
    50                  55                  60                  
Gln Glu Val Lys Ser Leu Cys Gly Leu Glu Ala Ser Gln Val Pro Ala
65                  70                  75                  80  
Glu Glu Ala Leu Ser Gly Ala Gly Glu Pro Tyr Asp Ile Ile Asp Ser
                85                  90                  95      
Ser Asp Glu Met Asp Ala Gln Glu Glu Asn Ile His Glu Arg Thr Val
            100                 105                 110         
Ser Arg Lys Lys Lys Ser Lys Arg His Lys Glu Glu Leu Asp Gly Ala
        115                 120                 125             
Gly Gly Glu Glu Tyr Pro Met Asp Ile Trp Leu Leu Leu Ala Ser Tyr
    130                 135                 140                 
Ile Arg Pro Glu Asp Ile Val Asn Phe Ser Leu Ile Cys Lys Asn Ala
145                 150                 155                 160 
Trp Thr Val Thr Cys Thr Ala Ala Phe Trp Thr Arg Leu Tyr Arg Arg
                165                 170                 175     
His Tyr Thr Leu Asp Ala Ser Leu Pro Leu Arg Leu Arg Pro Glu Ser
            180                 185                 190         
Met Glu Lys Leu His Cys Leu Arg Ala Cys Val Ile Arg Ser Leu Tyr
        195                 200                 205             
His Met Tyr Glu Pro Phe Ala Ala Arg Ile Ser Lys Asn Pro Ala Ile
    210                 215                 220                 
Pro Glu Ser Thr Pro Ser Thr Leu Lys Asn Ser Lys Cys Leu Leu Phe
225                 230                 235                 240 
Trp Cys Arg Lys Ile Val Gly Asn Arg Gln Glu Pro Met Trp Glu Phe
                245                 250                 255     
Asn Phe Lys Phe Lys Lys Gln Ser Pro Arg Leu Lys Ser Lys Cys Thr
            260                 265                 270         
Gly Gly Leu Gln Pro Pro Val Gln Tyr Glu Asp Val His Thr Asn Pro
        275                 280                 285             
Asp Gln Asp Cys Cys Leu Leu Gln Val Thr Thr Leu Asn Phe Ile Phe
    290                 295                 300                 
Ile Pro Ile Val Met Gly Met Ile Phe Thr Leu Phe Thr Ile Asn Val
305                 310                 315                 320 
Ser Thr Asp Met Arg His His Arg Val Arg Leu Val Phe Gln Asp Ser
                325                 330                 335     
Pro Val His Gly Gly Arg Lys Leu Arg Ser Glu Gln Gly Val Gln Val
            340                 345                 350         
Ile Leu Asp Pro Val His Ser Val Arg Leu Phe Asp Trp Trp His Pro
        355                 360                 365             
Gln Tyr Pro Phe Ser Leu Arg Ala
    370                 375     


<210> 6473
<211> 432
<212> PRT
<213> Homo sapiens

<400> 6473
Met Asp Ser Asn Gly Ile Arg Gln Phe Cys Val His Val Asn Asn Ser
 1               5                  10                  15      
Asn Leu Asn Tyr Phe Gln Lys Leu Gln Lys Val Asn Ala Thr Asn Phe
            20                  25                  30          
Gln Ala Leu Ala Ala Glu Phe Gly Gly Glu Ser Phe Thr Ser Thr Phe
        35                  40                  45              
Gln Thr Gln Ser Pro Pro Ser Phe Tyr Arg Ala Gly Asp Pro Ile Leu
    50                  55                  60                  
Thr Tyr Phe Pro Lys Trp Ser Val Ile Ser Leu Leu Arg Gln Pro Ala
65                  70                  75                  80  
Gly Val Gly Ala Gly Gly Leu Cys Ala Glu Ser Asn Pro Ala Gly Phe
                85                  90                  95      
Leu Glu Ser Lys Ser Thr Thr Cys Thr Arg Phe Phe Lys Asn Leu Ala
            100                 105                 110         
Ser Ser Cys Thr Leu Asp Ser Ala Leu Asn Ala Ala Ser Tyr Tyr Asn
        115                 120                 125             
Phe Thr Val Leu Lys Val Pro Arg Ser Met Thr Asp Pro Gln Asn Met
    130                 135                 140                 
Glu Val Thr Tyr Glu Ile Glu Thr Asn Gly Thr Phe Gly Ile Gln Lys
145                 150                 155                 160 
Val Ser Val Ser Leu Gly Gln Thr Asn Leu Thr Val Glu Pro Gly Ala
                165                 170                 175     
Ser Leu Gln Gln His Phe Ile Leu Arg Phe Arg Ala Phe Gln Gln Ser
            180                 185                 190         
Thr Ala Ala Ser Leu Thr Ser Pro Arg Ser Gly Asn Pro Gly Tyr Ile
        195                 200                 205             
Val Gly Lys Pro Leu Leu Ala Leu Thr Asp Asp Ile Ser Tyr Ser Val
    210                 215                 220                 
Ser Phe Leu Glu Leu Gly Gly Leu Gln Gly Asn Gly Ser Cys Ser Val
225                 230                 235                 240 
Lys Arg His Glu Val Gln Phe Gly Val Asn Ala Ile Ser Gly Cys Lys
                245                 250                 255     
Leu Arg Leu Lys Lys Ala Asp Cys Ser His Leu Gln Gln Glu Ile Tyr
            260                 265                 270         
Gln Thr Leu His Gly Arg Pro Arg Pro Glu Tyr Val Ala Ile Phe Gly
        275                 280                 285             
Asn Ala Asp Pro Ala Gln Lys Gly Gly Trp Thr Arg Ile Leu Asn Arg
    290                 295                 300                 
His Cys Ser Ile Ser Ala Ile Asn Cys Thr Ser Cys Cys Leu Ile Pro
305                 310                 315                 320 
Val Ser Leu Glu Ile Gln Val Leu Trp Ala Tyr Val Gly Leu Leu Ser
                325                 330                 335     
Asn Pro Gln Ala His Val Ser Gly Val Arg Phe Leu Tyr Gln Cys Gln
            340                 345                 350         
Ser Ile Gln Asp Ser Gln Gln Val Thr Glu Val Ser Leu Thr Thr Leu
        355                 360                 365             
Val Asn Phe Val Asp Ile Thr Gln Lys Pro Gln Pro Pro Arg Gly Gln
    370                 375                 380                 
Pro Lys Met Asp Trp Lys Trp Pro Phe Asp Phe Phe Pro Phe Lys Val
385                 390                 395                 400 
Ala Phe Ser Arg Gly Val Phe Ser Gln Lys Cys Ser Val Ser Pro Ile
                405                 410                 415     
Leu Ile Leu Cys Leu Leu Leu Leu Gly Val Leu Asn Leu Glu Thr Met
            420                 425                 430         


<210> 6474
<211> 618
<212> PRT
<213> Homo sapiens

<400> 6474
Gly Pro Gly Gly Pro Glu Cys Pro Met Arg Thr Pro Gln Leu Ala Leu
 1               5                  10                  15      
Leu Gln Val Phe Phe Leu Val Phe Pro Asp Gly Val Arg Pro Gln Pro
            20                  25                  30          
Ser Ser Ser Pro Ser Gly Ala Val Pro Thr Ser Leu Glu Leu Gln Arg
        35                  40                  45              
Gly Thr Asp Gly Gly Thr Leu Gln Ser Pro Ser Glu Ala Thr Ala Thr
    50                  55                  60                  
Arg Pro Ala Val Pro Gly Leu Pro Thr Val Val Pro Thr Leu Val Thr
65                  70                  75                  80  
Pro Ser Ala Pro Gly Asn Arg Thr Val Asp Leu Phe Pro Val Leu Pro
                85                  90                  95      
Ile Cys Val Cys Asp Leu Thr Pro Gly Ala Cys Asp Ile Asn Cys Cys
            100                 105                 110         
Cys Asp Arg Asp Cys Tyr Leu Leu His Pro Arg Thr Val Phe Ser Phe
        115                 120                 125             
Cys Leu Pro Gly Ser Val Arg Ser Ser Ser Trp Val Cys Val Asp Asn
    130                 135                 140                 
Ser Val Ile Phe Arg Ser Asn Ser Pro Phe Pro Ser Arg Val Phe Met
145                 150                 155                 160 
Asp Ser Asn Gly Ile Arg Gln Phe Cys Val His Val Asn Asn Ser Asn
                165                 170                 175     
Leu Asn Tyr Phe Gln Lys Leu Gln Lys Val Asn Ala Thr Asn Phe Gln
            180                 185                 190         
Ala Leu Ala Ala Glu Phe Gly Gly Glu Ser Phe Thr Ser Thr Phe Gln
        195                 200                 205             
Thr Gln Ser Pro Pro Ser Phe Tyr Arg Ala Gly Asp Pro Ile Leu Thr
    210                 215                 220                 
Tyr Phe Pro Lys Trp Ser Val Ile Ser Leu Leu Arg Gln Pro Ala Gly
225                 230                 235                 240 
Val Gly Ala Gly Gly Leu Cys Ala Glu Ser Asn Pro Ala Gly Phe Leu
                245                 250                 255     
Glu Ser Lys Ser Thr Thr Cys Thr Arg Phe Phe Lys Asn Leu Ala Ser
            260                 265                 270         
Ser Cys Thr Leu Asp Ser Ala Leu Asn Ala Ala Ser Tyr Tyr Asn Phe
        275                 280                 285             
Thr Val Leu Lys Val Pro Arg Ser Met Thr Asp Pro Gln Asn Met Glu
    290                 295                 300                 
Phe Gln Val Pro Val Ile Leu Thr Ser Gln Ala Asn Ala Pro Leu Leu
305                 310                 315                 320 
Ala Gly Asn Thr Cys Gln Asn Val Val Ser Gln Val Thr Tyr Glu Ile
                325                 330                 335     
Glu Thr Asn Gly Thr Phe Gly Ile Gln Lys Val Ser Val Ser Leu Gly
            340                 345                 350         
Gln Thr Asn Leu Thr Val Glu Pro Gly Ala Ser Leu Gln Gln His Phe
        355                 360                 365             
Ile Leu Arg Phe Arg Ala Phe Gln Gln Ser Thr Ala Ala Ser Leu Thr
    370                 375                 380                 
Ser Pro Arg Ser Gly Asn Pro Gly Tyr Ile Val Gly Lys Pro Leu Leu
385                 390                 395                 400 
Ala Leu Thr Asp Asp Ile Ser Tyr Ser Val Ser Phe Leu Glu Leu Gly
                405                 410                 415     
Gly Leu Gln Gly Asn Gly Ser Cys Ser Val Lys Arg His Glu Val Gln
            420                 425                 430         
Phe Gly Val Asn Ala Ile Ser Gly Cys Lys Leu Arg Leu Lys Lys Ala
        435                 440                 445             
Asp Cys Ser His Leu Gln Gln Glu Ile Tyr Gln Thr Leu His Gly Arg
    450                 455                 460                 
Pro Arg Pro Glu Tyr Val Ala Ile Phe Gly Asn Ala Asp Pro Ala Gln
465                 470                 475                 480 
Lys Gly Gly Trp Thr Arg Ile Leu Asn Arg His Cys Ser Ile Ser Ala
                485                 490                 495     
Ile Asn Cys Thr Ser Cys Cys Leu Ile Pro Val Ser Leu Glu Ile Gln
            500                 505                 510         
Val Leu Trp Ala Tyr Val Gly Leu Leu Ser Asn Pro Gln Ala His Val
        515                 520                 525             
Ser Gly Val Arg Phe Leu Tyr Gln Cys Gln Ser Ile Gln Asp Ser Gln
    530                 535                 540                 
Gln Val Thr Glu Val Ser Leu Thr Thr Leu Val Asn Phe Val Asp Ile
545                 550                 555                 560 
Thr Gln Lys Pro Gln Pro Pro Arg Gly Gln Pro Lys Met Asp Trp Lys
                565                 570                 575     
Trp Pro Phe Asp Phe Phe Pro Phe Lys Val Ala Phe Ser Arg Gly Val
            580                 585                 590         
Phe Ser Gln Lys Cys Ser Val Ser Pro Ile Leu Ile Leu Cys Leu Leu
        595                 600                 605             
Leu Leu Gly Val Leu Asn Leu Glu Thr Met
    610                 615             


<210> 6475
<211> 318
<212> PRT
<213> Homo sapiens

<400> 6475
Ile Pro Ala Trp Gly Pro Thr Lys Val Ala Asn Asn Val Thr Glu Phe
 1               5                  10                  15      
Ile Phe Leu Gly Leu Ser Gln Asp Ser Gly Met Arg Trp Ile Phe Phe
            20                  25                  30          
Val Leu Phe Leu Leu Phe Tyr Ile Val Ile Met Val Gly Asn Leu Leu
        35                  40                  45              
Ile Phe Leu Met Val Phe Ser Asp Pro Gln Leu His Thr Pro Met Tyr
    50                  55                  60                  
Phe Phe Leu Ser Asn Leu Ser Phe Val Asp Ile Ala Tyr Ser Ser Ala
65                  70                  75                  80  
Thr Ala Pro Lys Met Ile Ala Asp Phe Val Ser Glu Lys Lys Thr Ile
                85                  90                  95      
Ser Tyr Trp Gly Cys Ile Thr Gln Met Phe Thr Phe His Phe Phe Gly
            100                 105                 110         
Cys Ala Glu Ile Phe Val Leu Thr Val Met Ala Phe Asp Arg Tyr Ala
        115                 120                 125             
Ala Ile Cys Gln Pro Leu Arg Tyr Thr Val Ile Met Ser Ala Asn Ala
    130                 135                 140                 
Cys Thr Val Leu Ala Ser Leu Ser Trp Leu Gly Ala Leu Gly His Ser
145                 150                 155                 160 
Phe Val Gln Thr Leu Leu Thr Phe Gln Leu Pro Phe Cys Asn Ala Gln
                165                 170                 175     
Val Ile Asp His Tyr Phe Cys Asp Val His Pro Val Leu Lys Leu Ala
            180                 185                 190         
Cys Ala Asp Thr Thr Leu Ile Asn Met Leu Val Val Ala Asn Ser Gly
        195                 200                 205             
Leu Ile Ser Leu Gly Cys Phe Leu Ile Leu Leu Ala Ser Tyr Lys Val
    210                 215                 220                 
Ile Leu Leu Ser Leu Gln Lys Gln Ser Ala Glu Ser Arg Arg Lys Ala
225                 230                 235                 240 
Leu Ser Thr Cys Gly Ser His Leu Thr Val Val Thr Phe Phe Phe Val
                245                 250                 255     
Pro Cys Ile Phe Ile Tyr Leu Arg Pro Ser Thr Thr Phe Pro Leu Asp
            260                 265                 270         
Lys Ala Val Ser Val Phe Tyr Thr Thr Ile Thr Pro Met Leu Asn Pro
        275                 280                 285             
Leu Ile Tyr Thr Leu Arg Asn Glu Asp Val Lys Asn Ala Met Arg Gln
    290                 295                 300                 
Leu Trp Ser Ser Lys Ile Ser Leu Lys Glu Lys Gln Arg Gly
305                 310                 315             


<210> 6476
<211> 347
<212> PRT
<213> Homo sapiens

<400> 6476
Met Gly Asp Glu Leu Ala Pro Cys Pro Val Gly Thr Thr Ala Trp Pro
 1               5                  10                  15      
Ala Leu Ile Gln Leu Ile Ser Lys Thr Pro Cys Met Pro Gln Ala Ala
            20                  25                  30          
Ser Asn Thr Ser Leu Gly Leu Gly Asp Leu Arg Val Pro Ser Ser Met
        35                  40                  45              
Leu Tyr Trp Leu Phe Leu Pro Ser Ser Leu Leu Ala Ala Ala Thr Leu
    50                  55                  60                  
Ala Val Ser Pro Leu Leu Leu Val Thr Ile Leu Arg Asn Gln Arg Leu
65                  70                  75                  80  
Arg Gln Glu Pro His Tyr Leu Leu Pro Ala Asn Ile Leu Leu Ser Asp
                85                  90                  95      
Leu Ala Tyr Ile Leu Leu His Met Leu Ile Ser Ser Ser Ser Leu Gly
            100                 105                 110         
Gly Trp Glu Leu Gly Arg Met Ala Cys Gly Ile Leu Thr Asp Ala Val
        115                 120                 125             
Phe Ala Ala Cys Thr Ser Thr Ile Leu Ser Phe Thr Ala Ile Val Leu
    130                 135                 140                 
His Thr Tyr Leu Ala Val Ile His Pro Leu Arg Tyr Leu Ser Phe Met
145                 150                 155                 160 
Ser His Gly Ala Ala Trp Lys Ala Val Ala Leu Ile Trp Leu Val Ala
                165                 170                 175     
Cys Cys Phe Pro Thr Phe Leu Ile Trp Leu Ser Lys Trp Gln Asp Ala
            180                 185                 190         
Gln Leu Glu Glu Gln Gly Ala Ser Tyr Ile Leu Pro Pro Ser Met Gly
        195                 200                 205             
Thr Gln Pro Gly Cys Gly Leu Leu Val Ile Val Thr Tyr Thr Ser Ile
    210                 215                 220                 
Leu Cys Val Leu Phe Leu Cys Thr Ala Leu Ile Ala Asn Cys Phe Trp
225                 230                 235                 240 
Arg Ile Tyr Ala Glu Ala Lys Thr Ser Gly Ile Trp Gly Gln Gly Tyr
                245                 250                 255     
Ser Arg Ala Arg Gly Thr Leu Leu Ile His Ser Val Leu Ile Thr Leu
            260                 265                 270         
Tyr Val Ser Thr Gly Val Val Phe Ser Leu Asp Met Val Leu Thr Arg
        275                 280                 285             
Tyr His His Ile Asp Ser Gly Thr His Thr Trp Leu Leu Ala Ala Asn
    290                 295                 300                 
Ser Glu Val Leu Met Met Leu Pro Arg Ala Met Leu Pro Tyr Leu Tyr
305                 310                 315                 320 
Leu Leu Arg Tyr Arg Gln Leu Leu Gly Met Val Arg Gly His Leu Pro
                325                 330                 335     
Ser Arg Arg His Gln Ala Ile Phe Thr Ile Ser
            340                 345         


<210> 6477
<211> 2357
<212> PRT
<213> Homo sapiens

<400> 6477
Met Val Arg Phe Gly Asp Glu Leu Gly Gly Arg Tyr Gly Gly Pro Gly
 1               5                  10                  15      
Gly Gly Glu Arg Ala Arg Gly Gly Gly Ala Gly Gly Ala Gly Gly Pro
            20                  25                  30          
Gly Pro Gly Gly Leu Gln Pro Gly Gln Arg Val Leu Tyr Lys Gln Ser
        35                  40                  45              
Ile Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro Ile Pro Val
    50                  55                  60                  
Lys Gln Asn Cys Phe Thr Val Asn Arg Ser Leu Phe Val Phe Ser Glu
65                  70                  75                  80  
Asp Asn Val Val Arg Lys Tyr Ala Lys Arg Ile Thr Glu Trp Pro Tyr
                85                  90                  95      
Pro Ala Gly Arg Gly Arg Ala Gly Pro Gly Gly Asp Arg Val Leu Asn
            100                 105                 110         
Ser Arg Thr Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn
        115                 120                 125             
Cys Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Gly Asp Lys Thr
    130                 135                 140                 
Pro Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile
145                 150                 155                 160 
Phe Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Val Phe
                165                 170                 175     
His Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val
            180                 185                 190         
Val Val Leu Thr Gly Ile Leu Ala Thr Ala Gly Thr Asp Phe Asp Leu
        195                 200                 205             
Arg Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser
    210                 215                 220                 
Gly Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met
225                 230                 235                 240 
Val Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Met
                245                 250                 255     
Phe Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Lys Ala
            260                 265                 270         
Cys Phe Pro Asn Ser Thr Asp Ala Glu Pro Val Gly Asp Phe Pro Cys
        275                 280                 285             
Gly Lys Glu Ala Pro Ala Arg Leu Cys Glu Gly Asp Thr Glu Cys Arg
    290                 295                 300                 
Glu Tyr Trp Pro Gly Pro Asn Phe Gly Ile Thr Asn Phe Asp Asn Ile
305                 310                 315                 320 
Leu Phe Ala Ile Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp
                325                 330                 335     
Thr Asp Ile Leu Tyr Asn Thr Asn Asp Ala Ala Gly Asn Thr Trp Asn
            340                 345                 350         
Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu
        355                 360                 365             
Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu
    370                 375                 380                 
Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln
385                 390                 395                 400 
Ile Glu Arg Glu Leu Asn Gly Tyr Leu Glu Trp Ile Phe Lys Ala Glu
                405                 410                 415     
Glu Val Met Leu Ala Glu Glu Asp Arg Asn Ala Glu Glu Lys Ser Pro
            420                 425                 430         
Leu Asp Val Leu Lys Arg Ala Ala Thr Lys Lys Ser Arg Asn Asp Leu
        435                 440                 445             
Ile His Ala Glu Glu Gly Glu Asp Arg Phe Ala Asp Leu Cys Ala Val
    450                 455                 460                 
Gly Ser Pro Phe Ala Arg Ala Ser Leu Lys Ser Gly Lys Thr Glu Ser
465                 470                 475                 480 
Ser Ser Tyr Phe Arg Arg Lys Glu Lys Met Phe Arg Phe Phe Ile Arg
                485                 490                 495     
Arg Met Val Lys Ala Gln Ser Phe Tyr Trp Val Val Leu Cys Val Val
            500                 505                 510         
Ala Leu Asn Thr Leu Cys Val Ala Met Val His Tyr Asn Gln Pro Arg
        515                 520                 525             
Arg Leu Thr Thr Thr Leu Tyr Phe Ala Glu Phe Val Phe Leu Gly Leu
    530                 535                 540                 
Phe Leu Thr Glu Met Ser Leu Lys Met Tyr Gly Leu Gly Pro Arg Ser
545                 550                 555                 560 
Tyr Phe Arg Ser Ser Phe Asn Cys Phe Asp Phe Gly Val Ile Val Gly
                565                 570                 575     
Ser Val Phe Glu Val Val Trp Ala Ala Ile Lys Pro Gly Ser Ser Phe
            580                 585                 590         
Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val
        595                 600                 605             
Thr Lys Tyr Trp Ser Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn
    610                 615                 620                 
Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile
625                 630                 635                 640 
Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn
                645                 650                 655     
Phe Gln Asp Glu Thr Pro Thr Thr Asn Phe Asp Thr Phe Pro Ala Ala
            660                 665                 670         
Ile Leu Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala Val
        675                 680                 685             
Met Tyr His Gly Ile Glu Ser Gln Gly Gly Val Ser Lys Gly Met Phe
    690                 695                 700                 
Ser Ser Phe Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu
705                 710                 715                 720 
Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln
                725                 730                 735     
Glu Leu Thr Lys Asp Glu Glu Glu Met Glu Glu Ala Ala Asn Gln Lys
            740                 745                 750         
Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Met Ser
        755                 760                 765             
Ala Ala Asn Ile Ser Ile Ala Ala Arg Gln Gln Asn Ser Ala Lys Ala
    770                 775                 780                 
Arg Ser Val Trp Glu Gln Arg Ala Ser Gln Leu Arg Leu Gln Asn Leu
785                 790                 795                 800 
Arg Ala Ser Cys Glu Ala Leu Tyr Ser Glu Met Asp Pro Glu Glu Arg
                805                 810                 815     
Leu Arg Phe Ala Thr Thr Arg His Leu Arg Pro Asp Met Lys Thr His
            820                 825                 830         
Leu Asp Arg Pro Leu Val Val Glu Leu Gly Arg Asp Gly Ala Arg Gly
        835                 840                 845             
Pro Val Gly Gly Lys Ala Arg Pro Glu Ala Ala Glu Ala Pro Glu Gly
    850                 855                 860                 
Val Asp Pro Pro Arg Arg His His Arg His Arg Asp Lys Asp Lys Thr
865                 870                 875                 880 
Pro Ala Ala Gly Asp Gln Asp Arg Ala Glu Ala Pro Lys Ala Glu Ser
                885                 890                 895     
Gly Glu Pro Gly Ala Arg Glu Glu Arg Pro Arg Pro His Arg Ser His
            900                 905                 910         
Ser Lys Glu Ala Ala Gly Pro Pro Glu Ala Arg Ser Glu Arg Gly Arg
        915                 920                 925             
Gly Pro Gly Pro Glu Gly Gly Arg Arg His His Arg Arg Gly Ser Pro
    930                 935                 940                 
Glu Glu Ala Ala Glu Arg Glu Pro Arg Arg His Arg Ala His Arg His
945                 950                 955                 960 
Gln Asp Pro Ser Lys Glu Cys Ala Gly Ala Lys Gly Glu Arg Arg Ala
                965                 970                 975     
Arg His Arg Gly Gly Pro Arg Ala Gly Pro Arg Glu Ala Glu Ser Gly
            980                 985                 990         
Glu Glu Pro Ala Arg Arg His Arg Ala Arg His Lys Ala Gln Pro Ala
        995                 1000                1005            
His Glu Ala Val Glu Lys Glu Thr Thr Glu Lys Glu Ala Thr Glu Lys
    1010                1015                1020                
Glu Ala Glu Ile Val Glu Ala Asp Lys Glu Lys Glu Leu Arg Asn His
1025                1030                1035                1040
Gln Pro Arg Glu Pro His Cys Asp Leu Glu Thr Ser Gly Thr Val Thr
                1045                1050                1055    
Val Gly Pro Met His Thr Leu Pro Ser Thr Cys Leu Gln Lys Val Glu
            1060                1065                1070        
Glu Gln Pro Glu Asp Ala Asp Asn Gln Arg Asn Val Thr Arg Met Gly
        1075                1080                1085            
Ser Gln Pro Pro Asp Pro Asn Thr Ile Val His Ile Pro Val Met Leu
    1090                1095                1100                
Thr Gly Pro Leu Gly Glu Ala Thr Val Val Pro Ser Gly Asn Val Asp
1105                1110                1115                1120
Leu Glu Ser Gln Ala Glu Gly Lys Lys Glu Val Glu Ala Asp Asp Val
                1125                1130                1135    
Met Arg Ser Gly Pro Arg Pro Ile Val Pro Tyr Ser Ser Met Phe Cys
            1140                1145                1150        
Leu Ser Pro Thr Asn Leu Leu Arg Arg Phe Cys His Tyr Ile Val Thr
        1155                1160                1165            
Met Arg Tyr Phe Glu Val Val Ile Leu Val Val Ile Ala Leu Ser Ser
    1170                1175                1180                
Ile Ala Leu Ala Ala Glu Asp Pro Val Arg Thr Asp Ser Pro Arg Asn
1185                1190                1195                1200
Asn Ala Leu Lys Tyr Leu Asp Tyr Ile Phe Thr Gly Val Phe Thr Phe
                1205                1210                1215    
Glu Met Val Ile Lys Met Ile Asp Leu Gly Leu Leu Leu His Pro Gly
            1220                1225                1230        
Ala Tyr Phe Arg Asp Leu Trp Asn Ile Leu Asp Phe Ile Val Val Ser
        1235                1240                1245            
Gly Ala Leu Val Ala Phe Ala Phe Ser Gly Ser Lys Gly Lys Asp Ile
    1250                1255                1260                
Asn Thr Ile Lys Ser Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys
1265                1270                1275                1280
Thr Ile Lys Arg Leu Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val
                1285                1290                1295    
Asn Ser Leu Lys Asn Val Leu Asn Ile Leu Ile Val Tyr Met Leu Phe
            1300                1305                1310        
Met Phe Ile Phe Ala Val Ile Ala Val Gln Leu Phe Lys Gly Lys Phe
        1315                1320                1325            
Phe Tyr Cys Thr Asp Glu Ser Lys Glu Leu Glu Arg Asp Cys Arg Gly
    1330                1335                1340                
Gln Tyr Leu Asp Tyr Glu Lys Glu Glu Val Glu Ala Gln Pro Arg Gln
1345                1350                1355                1360
Trp Lys Lys Tyr Asp Phe His Tyr Asp Asn Val Leu Trp Ala Leu Leu
                1365                1370                1375    
Thr Leu Phe Thr Val Ser Thr Gly Glu Gly Trp Pro Met Val Leu Lys
            1380                1385                1390        
His Ser Val Asp Ala Thr Tyr Glu Glu Gln Gly Pro Ser Pro Gly Tyr
        1395                1400                1405            
Arg Met Glu Leu Ser Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro
    1410                1415                1420                
Phe Phe Phe Val Asn Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln
1425                1430                1435                1440
Glu Gln Gly Asp Lys Val Met Ser Glu Cys Ser Leu Glu Lys Asn Glu
                1445                1450                1455    
Arg Ala Cys Ile Asp Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg Tyr
            1460                1465                1470        
Met Pro Gln Asn Arg Gln Ser Phe Gln Tyr Lys Thr Trp Thr Phe Val
        1475                1480                1485            
Val Ser Pro Pro Phe Glu Tyr Phe Ile Met Ala Met Ile Ala Leu Asn
    1490                1495                1500                
Thr Val Val Leu Met Met Lys Phe Tyr Asp Ala Pro Tyr Glu Tyr Glu
1505                1510                1515                1520
Leu Met Leu Lys Cys Leu Asn Ile Val Phe Thr Ser Met Phe Ser Met
                1525                1530                1535    
Glu Cys Val Leu Lys Ile Ile Ala Phe Gly Val Leu Asn Tyr Phe Arg
            1540                1545                1550        
Asp Ala Trp Asn Val Phe Asp Phe Val Thr Val Leu Gly Ser Ile Thr
        1555                1560                1565            
Asp Ile Leu Val Thr Glu Ile Ala Asn Asn Phe Ile Asn Leu Ser Phe
    1570                1575                1580                
Leu Arg Leu Phe Arg Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly
1585                1590                1595                1600
Tyr Thr Ile Arg Ile Leu Leu Trp Thr Phe Val Gln Ser Phe Lys Ala
                1605                1610                1615    
Leu Pro Tyr Val Cys Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala
            1620                1625                1630        
Ile Ile Gly Met Gln Val Phe Gly Asn Ile Ala Leu Asp Asp Asp Thr
        1635                1640                1645            
Ser Ile Asn Arg His Asn Asn Phe Arg Thr Phe Leu Gln Ala Leu Met
    1650                1655                1660                
Leu Leu Phe Arg Ser Ala Thr Gly Glu Ala Trp His Glu Ile Met Leu
1665                1670                1675                1680
Ser Cys Leu Ser Asn Gln Ala Cys Asp Glu Gln Ala Asn Ala Thr Glu
                1685                1690                1695    
Cys Gly Ser Asp Phe Ala Tyr Phe Tyr Phe Val Ser Phe Ile Phe Leu
            1700                1705                1710        
Cys Ser Phe Leu Met Leu Asn Leu Phe Val Ala Val Ile Met Asp Asn
        1715                1720                1725            
Phe Glu Tyr Leu Thr Arg Asp Ser Ser Ile Leu Gly Pro His His Leu
    1730                1735                1740                
Asp Glu Phe Ile Arg Val Trp Ala Glu Tyr Asp Pro Ala Ala Cys Gly
1745                1750                1755                1760
Arg Ile Ser Tyr Asn Asp Met Phe Glu Met Leu Lys His Met Ser Pro
                1765                1770                1775    
Pro Leu Gly Leu Gly Lys Lys Cys Pro Ala Arg Val Ala Tyr Lys Arg
            1780                1785                1790        
Leu Val Arg Met Asn Met Pro Ile Ser Asn Glu Asp Met Thr Val His
        1795                1800                1805            
Phe Thr Ser Thr Leu Met Ala Leu Ile Arg Thr Ala Leu Glu Ile Lys
    1810                1815                1820                
Leu Ala Pro Ala Gly Thr Lys Gln His Gln Cys Asp Ala Glu Leu Arg
1825                1830                1835                1840
Lys Glu Ile Ser Val Val Trp Ala Asn Leu Pro Gln Lys Thr Leu Asp
                1845                1850                1855    
Leu Leu Val Pro Pro His Lys Pro Asp Glu Met Thr Val Gly Lys Val
            1860                1865                1870        
Tyr Ala Ala Leu Met Ile Phe Asp Phe Tyr Lys Gln Asn Lys Thr Thr
        1875                1880                1885            
Arg Asp Gln Met Gln Gln Ala Pro Gly Gly Leu Ser Gln Met Gly Pro
    1890                1895                1900                
Val Ser Leu Phe His Pro Leu Lys Ala Thr Leu Glu Gln Thr Gln Pro
1905                1910                1915                1920
Ala Val Leu Arg Gly Ala Arg Val Phe Leu Arg Gln Lys Ser Ser Thr
                1925                1930                1935    
Ser Leu Ser Asn Gly Gly Ala Ile Gln Asn Gln Glu Ser Gly Ile Lys
            1940                1945                1950        
Glu Ser Val Ser Trp Gly Thr Gln Arg Thr Gln Asp Ala Pro His Glu
        1955                1960                1965            
Ala Arg Pro Pro Leu Glu Arg Gly His Ser Thr Glu Ile Pro Val Gly
    1970                1975                1980                
Arg Ser Gly Ala Leu Ala Val Asp Val Gln Met Gln Ser Ile Thr Arg
1985                1990                1995                2000
Arg Gly Pro Asp Gly Glu Pro Gln Pro Gly Leu Glu Ser Gln Gly Arg
                2005                2010                2015    
Ala Ala Ser Met Pro Arg Leu Ala Ala Glu Thr Gln Pro Val Thr Asp
            2020                2025                2030        
Ala Ser Pro Met Lys Arg Ser Ile Ser Thr Leu Ala Gln Arg Pro Arg
        2035                2040                2045            
Gly Thr His Leu Cys Ser Thr Thr Pro Asp Arg Pro Pro Pro Ser Gln
    2050                2055                2060                
Ala Ser Ser His His His His His Arg Cys His Arg Arg Arg Asp Arg
2065                2070                2075                2080
Lys Gln Arg Ser Leu Glu Lys Gly Pro Ser Leu Ser Ala Asp Met Asp
                2085                2090                2095    
Gly Ala Pro Ser Ser Ala Val Gly Pro Gly Leu Pro Pro Gly Glu Gly
            2100                2105                2110        
Pro Thr Gly Cys Arg Arg Glu Arg Glu Arg Arg Gln Glu Arg Gly Arg
        2115                2120                2125            
Ser Gln Glu Arg Arg Gln Pro Ser Ser Ser Ser Ser Glu Lys Gln Arg
    2130                2135                2140                
Phe Tyr Ser Cys Asp Arg Phe Gly Gly Arg Glu Pro Pro Lys Pro Lys
2145                2150                2155                2160
Pro Ser Leu Ser Ser His Pro Thr Ser Pro Thr Ala Gly Gln Glu Pro
                2165                2170                2175    
Gly Pro His Pro Gln Gly Ser Gly Ser Val Asn Gly Ser Pro Leu Leu
            2180                2185                2190        
Ser Thr Ser Gly Ala Ser Thr Pro Gly Arg Gly Gly Arg Arg Gln Leu
        2195                2200                2205            
Pro Gln Thr Pro Leu Thr Pro Arg Pro Ser Ile Thr Tyr Lys Thr Ala
    2210                2215                2220                
Asn Ser Ser Pro Ile His Phe Ala Gly Ala Gln Thr Ser Leu Pro Ala
2225                2230                2235                2240
Phe Ser Pro Gly Arg Leu Ser Arg Gly Leu Ser Glu His Asn Ala Leu
                2245                2250                2255    
Leu Gln Arg Asp Pro Leu Ser Gln Pro Leu Ala Pro Gly Ser Arg Ile
            2260                2265                2270        
Gly Ser Asp Pro Tyr Leu Gly Gln Arg Leu Asp Ser Glu Ala Ser Val
        2275                2280                2285            
His Ala Leu Pro Glu Asp Thr Leu Thr Phe Glu Glu Ala Val Ala Thr
    2290                2295                2300                
Asn Ser Gly Arg Ser Ser Arg Thr Ser Tyr Val Ser Ser Leu Thr Ser
2305                2310                2315                2320
Gln Ser His Pro Leu Arg Arg Val Pro Asn Gly Tyr His Cys Thr Leu
                2325                2330                2335    
Gly Leu Ser Ser Gly Gly Arg Ala Arg His Ser Tyr His His Pro Asp
            2340                2345                2350        
Gln Asp His Trp Cys
        2355        


<210> 6478
<211> 2597
<212> PRT
<213> Homo sapiens

<400> 6478
Met Ala Ser Leu Phe His Gln Leu Gln Ile Leu Val Trp Lys Asn Trp
 1               5                  10                  15      
Leu Gly Val Lys Arg Gln Pro Leu Trp Thr Leu Val Leu Ile Leu Trp
            20                  25                  30          
Pro Val Ile Ile Phe Ile Ile Leu Ala Ile Thr Arg Thr Lys Phe Pro
        35                  40                  45              
Pro Thr Ala Lys Pro Thr Cys Tyr Leu Ala Pro Arg Asn Leu Pro Ser
    50                  55                  60                  
Thr Gly Phe Phe Pro Phe Leu Gln Thr Leu Leu Cys Asp Thr Asp Ser
65                  70                  75                  80  
Lys Cys Lys Asp Thr Pro Tyr Gly Pro Gln Asp Leu Leu Arg Arg Lys
                85                  90                  95      
Gly Ile Asp Asp Ala Leu Phe Lys Asp Ser Glu Ile Leu Arg Lys Ser
            100                 105                 110         
Ser Asn Leu Asp Lys Asp Ser Ser Leu Ser Phe Gln Ser Thr Gln Val
        115                 120                 125             
Pro Glu Arg Arg His Ala Ser Leu Ala Thr Val Phe Pro Ser Pro Ser
    130                 135                 140                 
Ser Asp Leu Glu Ile Pro Gly Thr Tyr Thr Phe Asn Gly Ser Gln Val
145                 150                 155                 160 
Leu Ala Arg Ile Leu Gly Leu Glu Lys Leu Leu Lys Gln Asn Ser Thr
                165                 170                 175     
Ser Glu Asp Ile Arg Arg Glu Leu Cys Asp Ser Tyr Ser Gly Tyr Ile
            180                 185                 190         
Val Asp Asp Ala Phe Ser Trp Thr Phe Leu Gly Arg Asn Val Phe Asn
        195                 200                 205             
Lys Phe Cys Leu Ser Asn Met Thr Leu Leu Glu Ser Ser Leu Gln Glu
    210                 215                 220                 
Leu Asn Lys Gln Phe Ser Gln Leu Ser Ser Asp Pro Asn Asn Gln Lys
225                 230                 235                 240 
Ile Val Phe Gln Glu Ile Val Arg Met Leu Ser Phe Phe Ser Gln Val
                245                 250                 255     
Gln Glu Gln Lys Ala Val Trp Gln Leu Leu Ser Ser Phe Pro Asn Val
            260                 265                 270         
Phe Gln Asn Asp Thr Ser Leu Ser Asn Leu Phe Asp Val Leu Arg Lys
        275                 280                 285             
Ala Asn Ser Val Leu Leu Val Val Gln Lys Val Tyr Pro Arg Phe Ala
    290                 295                 300                 
Thr Asn Glu Gly Phe Arg Thr Leu Gln Lys Ser Val Lys His Leu Leu
305                 310                 315                 320 
Tyr Thr Leu Asp Ser Pro Ala Gln Gly Asp Ser Asp Asn Ile Thr His
                325                 330                 335     
Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser Leu Ala
            340                 345                 350         
Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu Asn Ile
        355                 360                 365             
Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg Asn Val
    370                 375                 380                 
Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu Leu Gln
385                 390                 395                 400 
Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser Tyr Glu
                405                 410                 415     
Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu Ser Gln
            420                 425                 430         
Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe Ser Leu
        435                 440                 445             
Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser Leu Cys
    450                 455                 460                 
Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu Leu Gly
465                 470                 475                 480 
Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile Ser Lys
                485                 490                 495     
Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn Leu Asn
            500                 505                 510         
Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu Glu Asn
        515                 520                 525             
Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val Asn Asn
    530                 535                 540                 
Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met Phe Lys
545                 550                 555                 560 
Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly Met Ser
                565                 570                 575     
Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp Asn Arg
            580                 585                 590         
Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp Thr Asn
        595                 600                 605             
Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys Asn Leu
    610                 615                 620                 
Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu Thr Leu
625                 630                 635                 640 
Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Ala Ser Phe Phe
                645                 650                 655     
Pro Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe Ile
            660                 665                 670         
Arg Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro Leu
        675                 680                 685             
Leu Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser Val
    690                 695                 700                 
Pro Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro Gln
705                 710                 715                 720 
Gly Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile Thr
                725                 730                 735     
Thr Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys Gly
            740                 745                 750         
Asn His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln Ile
        755                 760                 765             
Ala Ser Lys Tyr Gly Ile Pro Ile Asn Ser Thr Pro Phe Cys Phe Ser
    770                 775                 780                 
Leu Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp Ala
785                 790                 795                 800 
Phe Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr Asn
                805                 810                 815     
Pro Val Thr Lys Ala Ile Met Glu Lys Ser Asn Val Thr Leu Arg Gln
            820                 825                 830         
Leu Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser Pro
        835                 840                 845             
Leu Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met Leu
    850                 855                 860                 
Gln Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe Ser
865                 870                 875                 880 
Val Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu Asp
                885                 890                 895     
Ile Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln Leu
            900                 905                 910         
Asn Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu Tyr
        915                 920                 925             
Asp Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu Ala
    930                 935                 940                 
Lys Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe Lys
945                 950                 955                 960 
Leu Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn Val
                965                 970                 975     
Phe Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys Thr
            980                 985                 990         
Ala Gln Thr Thr Arg Ser Leu Arg Thr Lys Ile Trp Ala Pro Gly Pro
        995                 1000                1005            
His Asn Ser Pro Ser His Asn Gln Ile Tyr Gly Arg Ala Phe Ile Tyr
    1010                1015                1020                
Leu Gln Asp Ser Ile Glu Arg Ala Ile Ile Glu Leu Gln Thr Gly Arg
1025                1030                1035                1040
Asn Ser Gln Glu Ile Ala Val Gln Val Gln Ala Ile Pro Tyr Pro Cys
                1045                1050                1055    
Phe Met Lys Asp Asn Phe Leu Thr Ser Val Ser Tyr Ser Leu Pro Ile
            1060                1065                1070        
Val Leu Met Val Ala Trp Val Val Phe Ile Ala Ala Phe Val Lys Lys
        1075                1080                1085            
Leu Val Tyr Glu Lys Asp Leu Arg Leu His Glu Tyr Met Lys Met Met
    1090                1095                1100                
Gly Val Asn Ser Cys Ser His Phe Phe Ala Trp Leu Ile Glu Ser Val
1105                1110                1115                1120
Gly Phe Leu Leu Val Thr Ile Val Ile Leu Ile Ile Ile Leu Lys Phe
                1125                1130                1135    
Gly Asn Ile Leu Pro Lys Thr Asn Gly Phe Ile Leu Phe Leu Tyr Phe
            1140                1145                1150        
Ser Asp Tyr Ser Phe Ser Val Ile Ala Met Ser Tyr Leu Ile Ser Val
        1155                1160                1165            
Phe Phe Asn Asn Thr Asn Ile Ala Ala Leu Ile Gly Ser Leu Ile Tyr
    1170                1175                1180                
Ile Ile Ala Phe Phe Pro Phe Ile Val Leu Val Thr Val Glu Asn Glu
1185                1190                1195                1200
Leu Ser Tyr Val Leu Lys Val Phe Met Ser Leu Leu Ser Pro Thr Ala
                1205                1210                1215    
Phe Ser Tyr Ala Ser Gln Tyr Ile Ala Arg Tyr Glu Glu Gln Gly Ile
            1220                1225                1230        
Gly Leu Gln Trp Glu Asn Met Tyr Thr Ser Pro Val Gln Asp Asp Thr
        1235                1240                1245            
Thr Ser Phe Gly Trp Leu Cys Cys Leu Ile Leu Ala Asp Ser Phe Ile
    1250                1255                1260                
Tyr Phe Leu Ile Ala Trp Tyr Val Arg Asn Val Phe Pro Gly Thr Tyr
1265                1270                1275                1280
Gly Met Ala Ala Pro Trp Tyr Phe Pro Ile Leu Pro Ser Tyr Trp Lys
                1285                1290                1295    
Glu Arg Phe Gly Cys Ala Glu Val Lys Pro Glu Lys Ser Asn Gly Leu
            1300                1305                1310        
Met Phe Thr Asn Ile Met Met Gln Asn Thr Asn Pro Ser Ala Ser Pro
        1315                1320                1325            
Glu Tyr Met Phe Ser Ser Asn Ile Glu Pro Glu Pro Lys Asp Leu Thr
    1330                1335                1340                
Val Gly Val Ala Leu His Gly Val Thr Lys Ile Tyr Gly Ser Lys Val
1345                1350                1355                1360
Ala Val Asp Asn Leu Asn Leu Asn Phe Tyr Glu Gly His Ile Thr Ser
                1365                1370                1375    
Leu Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser Met Leu
            1380                1385                1390        
Thr Gly Leu Phe Gly Ala Ser Ala Gly Thr Ile Phe Val Tyr Gly Lys
        1395                1400                1405            
Asp Ile Lys Thr Asp Leu His Thr Val Arg Lys Asn Met Gly Val Cys
    1410                1415                1420                
Met Gln His Asp Val Leu Phe Ser Tyr Leu Thr Thr Lys Glu His Leu
1425                1430                1435                1440
Leu Leu Tyr Gly Ser Ile Lys Val Pro His Trp Thr Lys Lys Gln Leu
                1445                1450                1455    
His Glu Glu Val Lys Arg Gln Thr Leu Lys Asp Thr Gly Leu Tyr Ser
            1460                1465                1470        
His Arg His Lys Arg Val Gly Thr Leu Ser Gly Gly Met Lys Arg Lys
        1475                1480                1485            
Leu Ser Ile Ser Ile Ala Leu Ile Gly Gly Ser Arg Val Val Ile Leu
    1490                1495                1500                
Asp Glu Pro Ser Thr Gly Val Asp Pro Cys Ser Arg Arg Ser Ile Trp
1505                1510                1515                1520
Asp Val Ile Ser Lys Asn Lys Thr Ala Arg Thr Ile Ile Leu Ser Thr
                1525                1530                1535    
His His Leu Asp Glu Ala Glu Val Leu Ser Asp Arg Ile Ala Phe Leu
            1540                1545                1550        
Glu Gln Gly Gly Leu Arg Cys Cys Gly Ser Pro Phe Tyr Leu Lys Glu
        1555                1560                1565            
Ala Phe Gly Asp Gly Tyr His Leu Thr Leu Thr Lys Lys Lys Ser Pro
    1570                1575                1580                
Asn Leu Asn Ala Asn Ala Val Cys Asp Thr Met Ala Val Thr Ala Met
1585                1590                1595                1600
Ile Gln Ser His Leu Pro Glu Ala Tyr Leu Lys Glu Asp Ile Gly Gly
                1605                1610                1615    
Glu Leu Val Tyr Val Leu Pro Pro Phe Ser Thr Lys Val Ser Gly Ala
            1620                1625                1630        
Tyr Leu Ser Leu Leu Arg Ala Leu Asp Asn Gly Met Gly Asp Leu Asn
        1635                1640                1645            
Ile Gly Cys Tyr Gly Ile Ser Asp Thr Thr Val Glu Glu Val Phe Leu
    1650                1655                1660                
Asn Leu Thr Lys Glu Ser Gln Lys Asn Ser Ala Met Ser Leu Glu His
1665                1670                1675                1680
Leu Thr Gln Lys Lys Ile Gly Asn Ser Asn Ala Asn Gly Ile Ser Thr
                1685                1690                1695    
Pro Asp Asp Leu Ser Val Ser Ser Ser Asn Phe Thr Asp Arg Asp Asp
            1700                1705                1710        
Lys Ile Leu Thr Arg Gly Glu Arg Leu Asp Gly Phe Gly Leu Leu Leu
        1715                1720                1725            
Lys Lys Ile Met Ala Ile Leu Ile Lys Arg Phe His His Thr Arg Arg
    1730                1735                1740                
Asn Trp Lys Gly Leu Ile Ala Gln Val Ile Leu Pro Ile Val Phe Val
1745                1750                1755                1760
Thr Thr Ala Met Gly Leu Gly Thr Leu Arg Asn Ser Ser Asn Ser Tyr
                1765                1770                1775    
Pro Glu Ile Gln Ile Ser Pro Ser Leu Tyr Gly Thr Ser Glu Gln Thr
            1780                1785                1790        
Ala Phe Tyr Ala Asn Tyr His Pro Ser Thr Glu Ala Leu Val Ser Ala
        1795                1800                1805            
Met Trp Asp Phe Pro Gly Ile Asp Asn Met Cys Leu Asn Thr Ser Asp
    1810                1815                1820                
Leu Gln Cys Leu Asn Lys Asp Ser Leu Glu Lys Trp Asn Thr Ser Gly
1825                1830                1835                1840
Glu Pro Ile Thr Asn Phe Gly Val Cys Ser Cys Ser Glu Asn Val Gln
                1845                1850                1855    
Glu Cys Pro Lys Phe Asn Tyr Ser Pro Pro His Arg Arg Thr Tyr Ser
            1860                1865                1870        
Ser Gln Val Ile Tyr Asn Leu Thr Gly Gln Arg Val Glu Asn Tyr Leu
        1875                1880                1885            
Ile Ser Thr Ala Asn Glu Phe Val Gln Lys Arg Tyr Gly Gly Trp Ser
    1890                1895                1900                
Phe Gly Leu Pro Leu Thr Lys Asp Leu Arg Phe Asp Ile Thr Gly Val
1905                1910                1915                1920
Pro Ala Asn Arg Thr Leu Ala Lys Val Trp Tyr Asp Pro Glu Gly Tyr
                1925                1930                1935    
His Ser Leu Pro Ala Tyr Leu Asn Ser Leu Asn Asn Phe Leu Leu Arg
            1940                1945                1950        
Val Asn Met Ser Lys Tyr Asp Ala Ala Arg His Gly Ile Ile Met Tyr
        1955                1960                1965            
Ser His Pro Tyr Pro Gly Val Gln Asp Gln Glu Gln Ala Thr Ile Ser
    1970                1975                1980                
Ser Leu Ile Asp Ile Leu Val Ala Leu Ser Ile Leu Met Gly Tyr Ser
1985                1990                1995                2000
Val Thr Thr Ala Ser Phe Val Thr Tyr Val Val Arg Glu His Gln Thr
                2005                2010                2015    
Lys Ala Lys Gln Leu Gln His Ile Ser Gly Ile Gly Val Thr Cys Tyr
            2020                2025                2030        
Trp Val Thr Asn Phe Ile Tyr Asp Met Val Phe Tyr Leu Val Pro Val
        2035                2040                2045            
Ala Phe Ser Ile Gly Ile Ile Ala Ile Phe Lys Leu Pro Ala Phe Tyr
    2050                2055                2060                
Ser Glu Asn Asn Leu Gly Ala Val Ser Leu Leu Leu Leu Leu Phe Gly
2065                2070                2075                2080
Tyr Ala Thr Phe Ser Trp Met Tyr Leu Leu Ala Gly Leu Phe His Glu
                2085                2090                2095    
Thr Gly Met Ala Phe Ile Thr Tyr Val Cys Val Asn Leu Phe Phe Gly
            2100                2105                2110        
Ile Asn Ser Ile Val Ser Leu Ser Val Val Tyr Phe Leu Ser Lys Glu
        2115                2120                2125            
Lys Pro Asn Asp Pro Thr Leu Glu Leu Ile Ser Glu Thr Leu Lys Arg
    2130                2135                2140                
Ile Phe Leu Ile Phe Pro Gln Phe Cys Phe Gly Tyr Gly Leu Ile Glu
2145                2150                2155                2160
Leu Ser Gln Gln Gln Ser Val Leu Asp Phe Leu Lys Ala Tyr Gly Val
                2165                2170                2175    
Glu Tyr Pro Asn Glu Thr Phe Glu Met Asn Lys Leu Gly Ala Met Phe
            2180                2185                2190        
Val Ala Leu Val Ser Gln Gly Thr Met Phe Phe Ser Leu Arg Leu Leu
        2195                2200                2205            
Ile Asn Glu Ser Leu Ile Lys Lys Leu Arg Leu Phe Phe Arg Lys Phe
    2210                2215                2220                
Asn Ser Ser His Val Arg Glu Thr Ile Asp Glu Asp Glu Asp Val Arg
2225                2230                2235                2240
Ala Glu Arg Leu Arg Val Glu Ser Gly Ala Ala Glu Phe Asp Leu Val
                2245                2250                2255    
Gln Leu Tyr Cys Leu Thr Lys Thr Tyr Gln Leu Ile His Lys Lys Ile
            2260                2265                2270        
Ile Ala Val Asn Asn Ile Ser Ile Gly Ile Pro Ala Gly Glu Cys Phe
        2275                2280                2285            
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Ile Phe Lys Met
    2290                2295                2300                
Leu Thr Gly Asp Ile Ile Pro Ser Ser Gly Asn Ile Leu Ile Arg Asn
2305                2310                2315                2320
Lys Thr Gly Ser Leu Gly His Val Asp Ser His Ser Ser Leu Val Gly
                2325                2330                2335    
Tyr Cys Pro Gln Glu Asp Ala Leu Asp Asp Leu Val Thr Val Glu Glu
            2340                2345                2350        
His Leu Tyr Phe Tyr Ala Arg Val His Gly Ile Pro Glu Lys Asp Ile
        2355                2360                2365            
Lys Glu Thr Val His Lys Leu Leu Arg Arg Leu His Leu Met Pro Phe
    2370                2375                2380                
Lys Asp Arg Ala Thr Ser Met Cys Ser Tyr Gly Thr Lys Arg Lys Leu
2385                2390                2395                2400
Ser Thr Ala Leu Ala Leu Ile Gly Lys Pro Ser Ile Leu Leu Leu Asp
                2405                2410                2415    
Glu Pro Ser Ser Gly Met Asp Pro Lys Ser Lys Arg His Leu Trp Lys
            2420                2425                2430        
Ile Ile Ser Glu Glu Val Gln Asn Lys Cys Ser Val Ile Leu Thr Ser
        2435                2440                2445            
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met
    2450                2455                2460                
Val Asn Gly Lys Phe Gln Cys Ile Gly Ser Leu Gln His Ile Lys Ser
2465                2470                2475                2480
Arg Phe Gly Arg Gly Phe Thr Val Lys Val His Leu Lys Asn Asn Lys
                2485                2490                2495    
Val Thr Met Glu Thr Leu Thr Lys Phe Met Gln Leu His Phe Pro Lys
            2500                2505                2510        
Thr Tyr Leu Lys Asp Gln His Leu Ser Met Leu Glu Tyr His Val Pro
        2515                2520                2525            
Val Thr Ala Gly Gly Val Ala Asn Ile Phe Asp Leu Leu Glu Thr Asn
    2530                2535                2540                
Lys Thr Ala Leu Asn Ile Thr Asn Phe Leu Val Ser Gln Thr Thr Leu
2545                2550                2555                2560
Glu Glu Val Phe Ile Asn Phe Ala Lys Asp Gln Lys Ser Tyr Glu Thr
                2565                2570                2575    
Ala Asp Thr Ser Ser Gln Gly Ser Thr Ile Ser Val Asp Ser Gln Asp
            2580                2585                2590        
Asp Gln Met Glu Ser
        2595        


<210> 6479
<211> 2277
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1707
<223> Xaa = Any Amino Acid

<400> 6479
Met Phe Thr Tyr Ile Lys Ile Ile Thr Ser Gly Asp Ser Asp Asn Ile
 1               5                  10                  15      
Thr His Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser
            20                  25                  30          
Leu Ala Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu
        35                  40                  45              
Asn Ile Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg
    50                  55                  60                  
Asn Val Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu
65                  70                  75                  80  
Leu Gln Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser
                85                  90                  95      
Tyr Glu Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu
            100                 105                 110         
Ser Gln Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe
        115                 120                 125             
Ser Leu Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser
    130                 135                 140                 
Leu Cys Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu
145                 150                 155                 160 
Leu Gly Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile
                165                 170                 175     
Ser Lys Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn
            180                 185                 190         
Leu Asn Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu
        195                 200                 205             
Glu Asn Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val
    210                 215                 220                 
Asn Asn Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met
225                 230                 235                 240 
Phe Lys Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly
                245                 250                 255     
Met Ser Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp
            260                 265                 270         
Asn Arg Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp
        275                 280                 285             
Thr Asn Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys
    290                 295                 300                 
Asn Leu Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu
305                 310                 315                 320 
Thr Leu Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Val Phe
                325                 330                 335     
Phe Pro Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe
            340                 345                 350         
Ile Arg Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro
        355                 360                 365             
Leu Leu Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser
    370                 375                 380                 
Val Pro Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro
385                 390                 395                 400 
Gln Gly Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile
                405                 410                 415     
Thr Thr Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys
            420                 425                 430         
Gly Asn His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln
        435                 440                 445             
Ile Ala Ser Lys Tyr Gly Ile Pro Ile Asn Thr Thr Pro Phe Cys Phe
    450                 455                 460                 
Ser Leu Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp
465                 470                 475                 480 
Ala Phe Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr
                485                 490                 495     
Asn Pro Val Thr Lys Ala Ile Met Glu Lys Ser Asp Val Thr Leu Arg
            500                 505                 510         
Gln Leu Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser
        515                 520                 525             
Pro Leu Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met
    530                 535                 540                 
Leu Gln Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe
545                 550                 555                 560 
Ser Val Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu
                565                 570                 575     
Asp Ile Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln
            580                 585                 590         
Leu Asn Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu
        595                 600                 605             
Tyr Asp Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu
    610                 615                 620                 
Ala Lys Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe
625                 630                 635                 640 
Lys Leu Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn
                645                 650                 655     
Val Phe Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys
            660                 665                 670         
Thr Ala Gln Thr Thr Arg Ser Leu Arg Thr Lys Ile Trp Ala Pro Gly
        675                 680                 685             
Pro His Asn Ser Pro Ser His Asn Gln Ile Tyr Gly Arg Ala Phe Ile
    690                 695                 700                 
Tyr Leu Gln Asp Ser Ile Glu Arg Ala Ile Ile Glu Leu Gln Thr Gly
705                 710                 715                 720 
Arg Asn Ser Gln Glu Ile Ala Val Gln Val Gln Ala Ile Pro Tyr Pro
                725                 730                 735     
Cys Phe Met Lys Asp Asn Phe Leu Thr Ser Val Ser Tyr Ser Leu Pro
            740                 745                 750         
Ile Val Leu Met Val Ala Trp Val Val Phe Ile Ala Ala Phe Val Lys
        755                 760                 765             
Lys Leu Val Tyr Glu Lys Asp Leu Arg Leu His Glu Tyr Met Lys Met
    770                 775                 780                 
Met Gly Val Asn Ser Cys Ser His Phe Phe Ala Trp Leu Ile Glu Ser
785                 790                 795                 800 
Val Gly Phe Leu Leu Val Thr Ile Val Ile Leu Ile Ile Ile Leu Lys
                805                 810                 815     
Phe Gly Asn Ile Leu Pro Lys Thr Asn Gly Phe Ile Leu Phe Leu Tyr
            820                 825                 830         
Phe Ser Asp Tyr Ser Phe Ser Val Ile Ala Met Ser Tyr Leu Ile Ser
        835                 840                 845             
Val Phe Phe Asn Asn Thr Asn Ile Ala Ala Leu Ile Gly Ser Leu Ile
    850                 855                 860                 
Tyr Ile Ile Ala Phe Phe Pro Phe Ile Val Leu Val Thr Val Glu Asn
865                 870                 875                 880 
Glu Leu Ser Tyr Val Leu Lys Val Phe Met Ser Leu Leu Ser Pro Thr
                885                 890                 895     
Ala Phe Ser Tyr Ala Ser Gln Tyr Ile Ala Arg Tyr Glu Glu Gln Gly
            900                 905                 910         
Ile Gly Leu Gln Trp Glu Asn Met Tyr Thr Ser Pro Val Gln Asp Asp
        915                 920                 925             
Thr Thr Ser Phe Gly Trp Leu Cys Cys Leu Ile Leu Ala Asp Ser Phe
    930                 935                 940                 
Ile Tyr Phe Leu Ile Ala Trp Tyr Val Arg Asn Val Phe Pro Gly Thr
945                 950                 955                 960 
Tyr Gly Met Ala Ala Pro Trp Tyr Phe Pro Ile Leu Pro Ser Tyr Trp
                965                 970                 975     
Lys Glu Arg Phe Gly Cys Ala Glu Val Lys Pro Glu Lys Ser Asn Gly
            980                 985                 990         
Leu Met Phe Thr Asn Ile Met Met Gln Asn Thr Asn Pro Ser Ala Ser
        995                 1000                1005            
Pro Glu Tyr Met Phe Ser Ser Asn Ile Glu Pro Glu Pro Lys Asp Leu
    1010                1015                1020                
Thr Val Gly Val Ala Leu His Gly Val Thr Lys Ile Tyr Gly Ser Lys
1025                1030                1035                1040
Val Ala Val Asp Asn Leu Asn Leu Asn Phe Tyr Glu Gly His Ile Thr
                1045                1050                1055    
Ser Leu Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser Met
            1060                1065                1070        
Leu Thr Gly Leu Phe Gly Ala Ser Ala Gly Thr Ile Phe Val Tyr Gly
        1075                1080                1085            
Lys Asp Ile Lys Thr Asp Leu His Thr Val Arg Lys Asn Met Gly Val
    1090                1095                1100                
Cys Met Gln His Asp Val Leu Phe Ser Tyr Leu Thr Thr Lys Glu His
1105                1110                1115                1120
Leu Leu Leu Tyr Gly Ser Ile Lys Val Pro His Trp Thr Lys Lys Gln
                1125                1130                1135    
Leu His Glu Glu Val Lys Arg Thr Leu Lys Asp Thr Gly Leu Tyr Ser
            1140                1145                1150        
His Arg His Lys Arg Val Gly Thr Leu Ser Gly Gly Met Lys Arg Lys
        1155                1160                1165            
Leu Ser Ile Ser Ile Ala Leu Ile Gly Gly Ser Arg Val Val Ile Leu
    1170                1175                1180                
Asp Glu Pro Ser Thr Gly Val Asp Pro Cys Ser Arg Arg Ser Ile Trp
1185                1190                1195                1200
Asp Val Ile Ser Lys Asn Lys Thr Ala Arg Thr Ile Ile Leu Ser Thr
                1205                1210                1215    
His His Leu Asp Glu Ala Glu Val Leu Ser Asp Arg Ile Ala Phe Leu
            1220                1225                1230        
Glu Gln Gly Gly Leu Arg Cys Cys Gly Ser Pro Phe Tyr Leu Lys Glu
        1235                1240                1245            
Ala Phe Gly Asp Gly Tyr His Leu Thr Leu Thr Lys Lys Lys Ser Pro
    1250                1255                1260                
Asn Leu Asn Ala Asn Ala Val Cys Asp Thr Met Ala Val Thr Ala Met
1265                1270                1275                1280
Ile Gln Ser His Leu Pro Glu Ala Tyr Leu Lys Glu Asp Ile Gly Gly
                1285                1290                1295    
Glu Leu Val Tyr Val Leu Pro Pro Phe Ser Thr Lys Val Ser Gly Ala
            1300                1305                1310        
Tyr Leu Ser Leu Leu Arg Ala Leu Asp Asn Gly Met Gly Asp Leu Asn
        1315                1320                1325            
Ile Gly Cys Tyr Gly Ile Ser Asp Thr Thr Val Glu Glu Val Phe Leu
    1330                1335                1340                
Asn Leu Thr Lys Glu Ser Gln Lys Asn Ser Ala Met Ser Leu Glu His
1345                1350                1355                1360
Leu Thr Gln Lys Lys Ile Gly Asn Ser Asn Ala Asn Gly Ile Ser Thr
                1365                1370                1375    
Pro Asp Asp Leu Ser Val Ser Ser Ser Asn Phe Thr Asp Arg Asp Asp
            1380                1385                1390        
Lys Ile Leu Thr Arg Gly Glu Arg Leu Asp Gly Phe Gly Leu Leu Leu
        1395                1400                1405            
Lys Lys Ile Met Ala Ile Leu Ile Lys Arg Phe His His Thr Arg Arg
    1410                1415                1420                
Asn Trp Lys Gly Leu Ile Ala Gln Val Ile Leu Pro Ile Val Phe Val
1425                1430                1435                1440
Thr Thr Ala Met Gly Leu Gly Thr Leu Arg Asn Ser Ser Asn Ser Tyr
                1445                1450                1455    
Pro Glu Ile Gln Ile Ser Pro Ser Leu Tyr Gly Thr Ser Glu Gln Thr
            1460                1465                1470        
Ala Phe Tyr Ala Asn Tyr His Pro Ser Thr Glu Ala Leu Val Ser Ala
        1475                1480                1485            
Met Trp Asp Phe Pro Gly Ile Asp Asn Met Cys Leu Asn Thr Ser Asp
    1490                1495                1500                
Leu Gln Cys Leu Asn Lys Asp Ser Leu Glu Lys Trp Asn Thr Ser Gly
1505                1510                1515                1520
Glu Pro Ile Thr Asn Phe Gly Val Cys Ser Cys Ser Glu Asn Val Gln
                1525                1530                1535    
Glu Cys Pro Lys Phe Asn Tyr Ser Pro Pro His Arg Arg Thr Tyr Ser
            1540                1545                1550        
Ser Gln Val Ile Tyr Asn Leu Thr Gly Gln Arg Val Glu Asn Tyr Leu
        1555                1560                1565            
Ile Ser Thr Ala Asn Glu Phe Val Gln Lys Arg Tyr Gly Gly Trp Ser
    1570                1575                1580                
Phe Gly Leu Pro Leu Thr Lys Asp Leu Arg Phe Asp Ile Thr Gly Val
1585                1590                1595                1600
Pro Ala Asn Arg Thr Leu Ala Lys Val Trp Tyr Asp Pro Glu Gly Tyr
                1605                1610                1615    
His Ser Leu Pro Ala Tyr Leu Asn Ser Leu Asn Asn Phe Leu Leu Arg
            1620                1625                1630        
Val Asn Met Ser Lys Tyr Asp Ala Ala Arg His Gly Ile Ile Met Tyr
        1635                1640                1645            
Ser His Pro Tyr Pro Gly Val Gln Asp Gln Glu Gln Ala Thr Ile Ser
    1650                1655                1660                
Ser Leu Ile Asp Ile Leu Val Ala Leu Ser Ile Leu Met Gly Tyr Ser
1665                1670                1675                1680
Val Thr Thr Ala Ser Phe Val Thr Tyr Val Val Arg Glu His Gln Thr
                1685                1690                1695    
Lys Ala Lys Gln Leu Gln His Ile Ser Gly Xaa Gly Val Thr Cys Tyr
            1700                1705                1710        
Trp Val Thr Asn Phe Ile Tyr Asp Met Val Phe Tyr Leu Val Pro Val
        1715                1720                1725            
Ala Phe Ser Ile Gly Ile Ile Ala Ile Phe Lys Leu Pro Ala Phe Tyr
    1730                1735                1740                
Ser Glu Asn Asn Leu Gly Ala Val Ser Leu Leu Leu Leu Leu Phe Gly
1745                1750                1755                1760
Tyr Ala Thr Phe Ser Trp Met Tyr Leu Leu Ala Gly Leu Phe His Glu
                1765                1770                1775    
Thr Gly Met Ala Phe Ile Thr Tyr Val Cys Val Asn Leu Phe Phe Gly
            1780                1785                1790        
Ile Asn Ser Ile Val Ser Leu Ser Val Val Tyr Phe Leu Ser Lys Glu
        1795                1800                1805            
Lys Pro Asn Asp Pro Thr Leu Glu Leu Ile Ser Glu Thr Leu Lys Arg
    1810                1815                1820                
Ile Phe Leu Ile Phe Pro Gln Phe Cys Phe Gly Tyr Gly Leu Ile Glu
1825                1830                1835                1840
Leu Ser Gln Gln Gln Ser Val Leu Asp Phe Leu Lys Ala Tyr Gly Val
                1845                1850                1855    
Glu Tyr Pro Asn Glu Thr Phe Glu Met Asn Lys Leu Gly Ala Met Phe
            1860                1865                1870        
Val Ala Leu Val Ser Gln Gly Thr Met Phe Phe Ser Leu Arg Leu Leu
        1875                1880                1885            
Ile Asn Glu Ser Leu Ile Lys Lys Leu Arg Leu Phe Phe Arg Lys Phe
    1890                1895                1900                
Asn Ser Ser His Val Arg Glu Thr Ile Asp Glu Asp Glu Asp Val Arg
1905                1910                1915                1920
Ala Glu Arg Leu Arg Val Glu Ser Gly Ala Ala Glu Phe Asp Leu Val
                1925                1930                1935    
Gln Leu Tyr Cys Leu Thr Lys Thr Tyr Gln Leu Ile His Lys Lys Ile
            1940                1945                1950        
Ile Ala Val Asn Asn Ile Ser Ile Gly Ile Pro Ala Gly Glu Cys Phe
        1955                1960                1965            
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Ile Phe Lys Met
    1970                1975                1980                
Leu Thr Gly Asp Ile Ile Pro Ser Ser Gly Asn Ile Leu Ile Arg Asn
1985                1990                1995                2000
Lys Thr Gly Ser Leu Gly His Val Asp Ser His Ser Ser Leu Val Gly
                2005                2010                2015    
Tyr Cys Pro Gln Glu Asp Ala Leu Asp Asp Leu Val Thr Val Glu Glu
            2020                2025                2030        
His Leu Tyr Phe Tyr Ala Arg Val His Gly Ile Pro Glu Lys Asp Ile
        2035                2040                2045            
Lys Glu Thr Val His Lys Leu Leu Arg Arg Leu His Leu Met Pro Phe
    2050                2055                2060                
Lys Asp Arg Ala Thr Ser Met Cys Ser Tyr Gly Thr Lys Arg Lys Leu
2065                2070                2075                2080
Ser Thr Ala Leu Ala Leu Ile Gly Lys Pro Ser Ile Leu Leu Leu Asp
                2085                2090                2095    
Glu Pro Ser Ser Gly Met Asp Pro Lys Ser Lys Arg His Leu Trp Lys
            2100                2105                2110        
Ile Ile Ser Glu Glu Val Gln Asn Lys Cys Ser Val Ile Leu Thr Ser
        2115                2120                2125            
His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met
    2130                2135                2140                
Val Asn Gly Lys Phe Gln Cys Ile Gly Ser Leu Gln His Ile Lys Ser
2145                2150                2155                2160
Arg Phe Gly Arg Gly Phe Thr Val Lys Val His Leu Lys Asn Asn Lys
                2165                2170                2175    
Val Thr Met Glu Thr Leu Thr Lys Phe Met Gln Leu His Phe Pro Lys
            2180                2185                2190        
Thr Tyr Leu Lys Asp Gln His Leu Ser Met Leu Glu Tyr His Val Pro
        2195                2200                2205            
Val Thr Ala Gly Gly Val Ala Asn Ile Phe Asp Leu Leu Glu Thr Asn
    2210                2215                2220                
Lys Thr Ala Leu Asn Ile Thr Asn Phe Leu Val Ser Gln Thr Thr Leu
2225                2230                2235                2240
Glu Glu Val Phe Ile Asn Phe Ala Lys Asp Gln Lys Ser Tyr Glu Thr
                2245                2250                2255    
Ala Asp Thr Ser Ser Gln Gly Ser Thr Ile Ser Val Asp Ser Gln Asp
            2260                2265                2270        
Asp Gln Met Glu Ser
        2275        


<210> 6480
<211> 1194
<212> PRT
<213> Homo sapiens

<400> 6480
Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val
 1               5                  10                  15      
Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala
            20                  25                  30          
Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly
        35                  40                  45              
Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu
    50                  55                  60                  
Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu
65                  70                  75                  80  
Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu
                85                  90                  95      
Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser
            100                 105                 110         
Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile
        115                 120                 125             
Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly
    130                 135                 140                 
Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile
145                 150                 155                 160 
Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln
                165                 170                 175     
Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu
            180                 185                 190         
Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp
        195                 200                 205             
Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp
    210                 215                 220                 
Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly
225                 230                 235                 240 
Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala
                245                 250                 255     
His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg
            260                 265                 270         
Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val
        275                 280                 285             
Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg
    290                 295                 300                 
Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp
305                 310                 315                 320 
Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly
                325                 330                 335     
Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp
            340                 345                 350         
Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe
        355                 360                 365             
Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu
    370                 375                 380                 
Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu
385                 390                 395                 400 
Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala
                405                 410                 415     
Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys
            420                 425                 430         
Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser
        435                 440                 445             
Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly
    450                 455                 460                 
Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp
465                 470                 475                 480 
Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His
                485                 490                 495     
Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile
            500                 505                 510         
Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys
        515                 520                 525             
Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys
    530                 535                 540                 
Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe
545                 550                 555                 560 
Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr
                565                 570                 575     
Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu
            580                 585                 590         
Pro Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu
        595                 600                 605             
Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys
    610                 615                 620                 
Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu
625                 630                 635                 640 
Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser
                645                 650                 655     
Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr
            660                 665                 670         
Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly
        675                 680                 685             
Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp
    690                 695                 700                 
Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu
705                 710                 715                 720 
Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr
                725                 730                 735     
Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly
            740                 745                 750         
Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr
        755                 760                 765             
Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala
    770                 775                 780                 
Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala
785                 790                 795                 800 
Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys
                805                 810                 815     
Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr
            820                 825                 830         
Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser
        835                 840                 845             
Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys
    850                 855                 860                 
Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys
865                 870                 875                 880 
Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser
                885                 890                 895     
Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg
            900                 905                 910         
Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala
        915                 920                 925             
Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu
    930                 935                 940                 
Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu
945                 950                 955                 960 
Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met
                965                 970                 975     
Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro
            980                 985                 990         
Pro His Leu Thr Ala Glu Glu Thr Pro Leu Phe Leu Ala Glu Pro Ala
        995                 1000                1005            
Leu Pro Lys Gly Leu Pro Pro Pro Leu Gln Gln Gln Gln Gln Pro Pro
    1010                1015                1020                
Pro Gln Gln Lys Ser Leu Met Asp Gln Leu Gln Gly Val Val Ser Asn
1025                1030                1035                1040
Phe Ser Thr Ala Ile Pro Asp Phe His Ala Val Leu Ala Gly Pro Gly
                1045                1050                1055    
Gly Pro Gly Asn Gly Leu Arg Ser Leu Tyr Pro Pro Pro Pro Pro Pro
            1060                1065                1070        
Gln His Leu Gln Met Leu Pro Leu Gln Leu Ser Thr Phe Gly Glu Glu
        1075                1080                1085            
Leu Val Ser Pro Pro Ala Asp Asp Asp Asp Asp Ser Glu Arg Phe Lys
    1090                1095                1100                
Leu Leu Gln Glu Tyr Val Tyr Glu His Glu Arg Glu Gly Asn Thr Glu
1105                1110                1115                1120
Glu Asp Glu Leu Glu Glu Glu Glu Glu Asp Leu Gln Ala Ala Ser Lys
                1125                1130                1135    
Leu Thr Pro Asp Asp Ser Pro Ala Leu Thr Pro Pro Ser Pro Phe Arg
            1140                1145                1150        
Asp Ser Val Ala Ser Gly Ser Ser Val Pro Ser Ser Pro Val Ser Glu
        1155                1160                1165            
Ser Val Leu Cys Thr Pro Pro Asn Val Ser Tyr Ala Ser Val Ile Leu
    1170                1175                1180                
Arg Asp Tyr Lys Gln Ser Ser Ser Thr Leu
1185                1190                


<210> 6481
<211> 260
<212> PRT
<213> Homo sapiens

<400> 6481
Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp
 1               5                  10                  15      
Asp Asp Asp Val Ala Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu
            20                  25                  30          
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala
        35                  40                  45              
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser
    50                  55                  60                  
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser
65                  70                  75                  80  
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile
                85                  90                  95      
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp
            100                 105                 110         
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val
        115                 120                 125             
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg
    130                 135                 140                 
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr
145                 150                 155                 160 
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile
                165                 170                 175     
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu
            180                 185                 190         
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser
        195                 200                 205             
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu
    210                 215                 220                 
Ser Gln Pro Gln Gly Ala Phe Leu Lys Ser Cys Pro Glu Pro Gln Pro
225                 230                 235                 240 
Asn Arg Glu Glu Gly Ala Leu Trp Ser Ser Gly Ala Pro Gly Pro Ala
                245                 250                 255     
Gly Arg Asp Asp
            260 


<210> 6482
<211> 251
<212> PRT
<213> Homo sapiens

<400> 6482
Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp
 1               5                  10                  15      
Asp Asp Asp Val Ala Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu
            20                  25                  30          
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala
        35                  40                  45              
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser
    50                  55                  60                  
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser
65                  70                  75                  80  
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile
                85                  90                  95      
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp
            100                 105                 110         
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val
        115                 120                 125             
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg
    130                 135                 140                 
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr
145                 150                 155                 160 
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile
                165                 170                 175     
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu
            180                 185                 190         
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser
        195                 200                 205             
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu
    210                 215                 220                 
Ser Gln Thr Met Trp Arg Gly Pro Cys Leu Thr Pro Arg Arg Pro Ser
225                 230                 235                 240 
Ser Thr Arg Ala Arg Arg Ala Gly Arg Lys Ser
                245                 250     


<210> 6483
<211> 288
<212> PRT
<213> Homo sapiens

<400> 6483
Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp
 1               5                  10                  15      
Asp Asp Asp Val Ala Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu
            20                  25                  30          
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala
        35                  40                  45              
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser
    50                  55                  60                  
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser
65                  70                  75                  80  
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile
                85                  90                  95      
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp
            100                 105                 110         
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val
        115                 120                 125             
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg
    130                 135                 140                 
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr
145                 150                 155                 160 
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile
                165                 170                 175     
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu
            180                 185                 190         
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser
        195                 200                 205             
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu
    210                 215                 220                 
Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala
225                 230                 235                 240 
Val Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys
                245                 250                 255     
Tyr Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys
            260                 265                 270         
Val Ile Leu Gly Ile Val Ile Ala Ser Thr Val Gly Gly Ile Phe Ala
        275                 280                 285             


<210> 6484
<211> 582
<212> PRT
<213> Homo sapiens

<400> 6484
Met Ala Ala Arg Ser Trp Gln Asp Glu Leu Ala Gln Gln Ala Glu Glu
 1               5                  10                  15      
Gly Ser Ala Arg Leu Arg Glu Met Leu Ser Val Gly Leu Gly Phe Leu
            20                  25                  30          
Arg Thr Glu Leu Gly Leu Asp Leu Gly Leu Glu Pro Lys Arg Tyr Pro
        35                  40                  45              
Gly Trp Val Ile Leu Val Gly Thr Gly Ala Leu Gly Leu Leu Leu Leu
    50                  55                  60                  
Phe Leu Leu Gly Tyr Gly Trp Ala Ala Ala Cys Ala Gly Ala Arg Lys
65                  70                  75                  80  
Lys Arg Arg Ser Pro Pro Arg Lys Arg Glu Glu Ala Ala Ala Val Pro
                85                  90                  95      
Ala Ala Ala Pro Asp Asp Leu Ala Leu Leu Lys Asn Leu Arg Ser Glu
            100                 105                 110         
Glu Gln Lys Lys Lys Asn Arg Lys Lys Leu Ser Glu Lys Pro Lys Pro
        115                 120                 125             
Asn Gly Arg Thr Val Glu Val Ala Glu Gly Glu Ala Val Arg Thr Pro
    130                 135                 140                 
Gln Ser Val Thr Ala Lys Gln Pro Pro Glu Ile Asp Lys Lys Asn Glu
145                 150                 155                 160 
Lys Ser Lys Lys Asn Lys Lys Lys Ser Lys Ser Asp Ala Lys Ala Val
                165                 170                 175     
Gln Asn Ser Ser Arg His Asp Gly Lys Glu Val Asp Glu Gly Ala Trp
            180                 185                 190         
Glu Thr Lys Ile Ser His Arg Glu Lys Arg Gln Gln Arg Lys Arg Asp
        195                 200                 205             
Lys Val Leu Thr Asp Ser Gly Ser Leu Asp Ser Thr Ile Pro Gly Ile
    210                 215                 220                 
Glu Asn Thr Ile Thr Val Thr Thr Glu Gln Leu Thr Thr Ala Ser Phe
225                 230                 235                 240 
Pro Val Gly Ser Lys Lys Asn Lys Gly Asp Ser His Leu Asn Val Gln
                245                 250                 255     
Val Ser Asn Phe Lys Ser Gly Lys Gly Asp Ser Thr Leu Gln Val Ser
            260                 265                 270         
Ser Gly Leu Asn Glu Asn Leu Thr Val Asn Gly Gly Gly Trp Asn Glu
        275                 280                 285             
Lys Ser Val Lys Leu Ser Ser Gln Ile Ser Ala Gly Glu Glu Lys Trp
    290                 295                 300                 
Asn Ser Val Ser Pro Ala Ser Ala Gly Lys Arg Lys Thr Glu Pro Ser
305                 310                 315                 320 
Ala Trp Ser Gln Asp Thr Gly Asp Ala Asn Thr Asn Gly Lys Asp Trp
                325                 330                 335     
Gly Arg Ser Trp Ser Asp Arg Ser Ile Phe Ser Gly Ile Gly Ser Thr
            340                 345                 350         
Ala Glu Pro Val Ser Gln Ser Thr Thr Ser Asp Tyr Gln Trp Asp Val
        355                 360                 365             
Ser Arg Asn Gln Pro Tyr Ile Asp Asp Glu Trp Ser Gly Leu Asn Gly
    370                 375                 380                 
Leu Ser Ser Ala Asp Pro Asn Ser Asp Trp Asn Ala Pro Ala Glu Glu
385                 390                 395                 400 
Trp Gly Asn Trp Val Asp Glu Glu Arg Ala Ser Leu Leu Lys Ser Gln
                405                 410                 415     
Glu Pro Ile Pro Asp Asp Gln Lys Val Ser Asp Asp Asp Lys Glu Lys
            420                 425                 430         
Gly Glu Gly Ala Leu Pro Thr Gly Lys Ser Lys Lys Lys Lys Lys Lys
        435                 440                 445             
Lys Lys Lys Gln Gly Glu Asp Asn Ser Thr Ala Gln Asp Thr Glu Glu
    450                 455                 460                 
Leu Glu Lys Glu Ile Arg Glu Asp Leu Pro Val Asn Thr Ser Lys Thr
465                 470                 475                 480 
Arg Pro Lys Gln Glu Lys Ala Phe Ser Leu Lys Thr Ile Ser Thr Ser
                485                 490                 495     
Asp Pro Ala Glu Val Leu Val Lys Asn Ser Gln Pro Ile Lys Thr Leu
            500                 505                 510         
Pro Pro Ala Thr Ser Thr Glu Pro Ser Val Ile Leu Ser Lys Ser Asp
        515                 520                 525             
Ser Asp Lys Ser Ser Ser Gln Val Pro Pro Ile Leu Gln Glu Thr Asp
    530                 535                 540                 
Lys Ser Lys Ser Asn Thr Lys Gln Asn Ser Val Pro Pro Ser Gln Thr
545                 550                 555                 560 
Lys Ser Glu Thr Ser Trp Glu Ser Pro Lys Gln Ile Lys Lys Lys Lys
                565                 570                 575     
Lys Ala Arg Arg Glu Thr
            580         


<210> 6485
<211> 314
<212> PRT
<213> Homo sapiens

<400> 6485
Pro Arg Ala Pro Gly Arg Ser Leu His Pro Pro Ala Pro Gly Thr Val
 1               5                  10                  15      
Asp Ser Thr Thr Leu Ser Ser Ala Leu Ser Ala Pro Lys Gln Pro Gly
            20                  25                  30          
Thr Ala Gln Arg Pro Ala Cys Arg His Gly Lys Ser Leu Ser His Leu
        35                  40                  45              
Pro Leu His Ser Ser Lys Glu Asp Ala Tyr Asp Gly Val Thr Ser Glu
    50                  55                  60                  
Asn Met Arg Asn Gly Leu Val Asn Ser Glu Val His Asn Glu Asp Gly
65                  70                  75                  80  
Arg Asn Gly Asp Val Ser Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg
                85                  90                  95      
Asp Ser Val Thr Cys Pro Thr Cys Gln Gly Thr Gly Arg Ile Pro Arg
            100                 105                 110         
Gly Gln Glu Asn Gln Leu Val Ala Leu Ile Pro Tyr Ser Asp Gln Arg
        115                 120                 125             
Leu Arg Pro Arg Arg Thr Lys Leu Tyr Val Met Ala Ser Val Phe Val
    130                 135                 140                 
Cys Leu Leu Leu Ser Gly Leu Ala Val Phe Phe Leu Phe Pro Arg Ser
145                 150                 155                 160 
Ile Asp Val Lys Tyr Ile Gly Val Lys Ser Ala Tyr Val Ser Tyr Asp
                165                 170                 175     
Val Gln Lys Arg Thr Ile Tyr Leu Asn Ile Thr Asn Thr Leu Asn Ile
            180                 185                 190         
Thr Asn Asn Asn Tyr Tyr Ser Val Glu Val Glu Asn Ile Thr Ala Gln
        195                 200                 205             
Val Gln Phe Ser Lys Thr Val Ile Gly Lys Ala Arg Leu Asn Asn Ile
    210                 215                 220                 
Ser Ile Ile Gly Pro Leu Asp Met Lys Gln Ile Asp Tyr Thr Val Pro
225                 230                 235                 240 
Thr Val Ile Ala Glu Glu Met Ser Tyr Met Tyr Asp Phe Cys Thr Leu
                245                 250                 255     
Ile Ser Ile Lys Val His Asn Ile Val Leu Met Met Gln Val Thr Val
            260                 265                 270         
Thr Thr Thr Tyr Phe Gly His Ser Glu Gln Ile Ser Gln Glu Arg Tyr
        275                 280                 285             
Gln Tyr Val Asp Cys Gly Arg Asn Thr Thr Tyr Gln Leu Gly Gln Ser
    290                 295                 300                 
Glu Tyr Leu Asn Val Leu Gln Pro Gln Gln
305                 310                 


<210> 6486
<211> 274
<212> PRT
<213> Homo sapiens

<400> 6486
Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp
 1               5                  10                  15      
Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn
            20                  25                  30          
Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe
        35                  40                  45              
Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys
    50                  55                  60                  
Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala
65                  70                  75                  80  
Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu
                85                  90                  95      
Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala
            100                 105                 110         
Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val
        115                 120                 125             
Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu
    130                 135                 140                 
Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val
145                 150                 155                 160 
Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile
                165                 170                 175     
Gly Lys Ala Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met
            180                 185                 190         
Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser
        195                 200                 205             
Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile
    210                 215                 220                 
Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser
225                 230                 235                 240 
Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn
                245                 250                 255     
Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro
            260                 265                 270         
Gln Gln
        


<210> 6487
<211> 501
<212> PRT
<213> Homo sapiens

<400> 6487
Met Arg Ala Glu Glu Pro Cys Ala Pro Gly Ala Pro Ser Ala Leu Gly
 1               5                  10                  15      
Ala Gln Arg Thr Pro Gly Pro Glu Leu Arg Leu Ser Ser Gln Leu Leu
            20                  25                  30          
Pro Glu Leu Cys Thr Phe Val Val Arg Val Leu Phe Tyr Leu Gly Pro
        35                  40                  45              
Val Tyr Leu Ala Gly Tyr Leu Gly Leu Ser Ile Thr Trp Leu Leu Leu
    50                  55                  60                  
Gly Ala Leu Leu Trp Met Trp Trp Arg Arg Asn Arg Arg Gly Lys Leu
65                  70                  75                  80  
Gly Arg Leu Ala Ala Ala Phe Glu Phe Leu Asp Asn Glu Arg Glu Phe
                85                  90                  95      
Ile Ser Arg Glu Leu Arg Gly Gln His Leu Pro Ala Trp Ile His Phe
            100                 105                 110         
Pro Asp Val Glu Arg Val Glu Trp Ala Asn Lys Ile Ile Ser Gln Thr
        115                 120                 125             
Trp Pro Tyr Leu Ser Met Ile Met Glu Ser Lys Phe Arg Glu Lys Leu
    130                 135                 140                 
Glu Pro Lys Ile Arg Glu Lys Ser Ile His Leu Arg Thr Phe Thr Phe
145                 150                 155                 160 
Thr Lys Leu Tyr Phe Gly Gln Lys Cys Pro Arg Val Asn Gly Val Lys
                165                 170                 175     
Ala His Thr Asn Thr Cys Asn Arg Arg Arg Val Thr Val Asp Leu Gln
            180                 185                 190         
Ile Cys Tyr Ile Gly Asp Cys Glu Ile Ser Val Glu Leu Gln Lys Ile
        195                 200                 205             
Gln Ala Gly Val Asn Gly Ile Gln Leu Gln Gly Thr Leu Arg Val Ile
    210                 215                 220                 
Leu Glu Pro Leu Leu Val Asp Lys Pro Phe Val Gly Ala Val Thr Val
225                 230                 235                 240 
Phe Phe Leu Gln Lys Gln His Leu Gln Ile Asn Trp Thr Gly Leu Thr
                245                 250                 255     
Asn Leu Leu Asp Ala Pro Gly Ile Asn Asp Val Ser Asp Ser Leu Leu
            260                 265                 270         
Glu Asp Leu Ile Ala Thr His Leu Val Leu Pro Asn Arg Val Thr Val
        275                 280                 285             
Pro Val Lys Lys Gly Leu Asp Leu Thr Asn Leu Arg Phe Pro Leu Pro
    290                 295                 300                 
Cys Gly Val Ile Arg Val His Leu Leu Glu Ala Glu Gln Leu Ala Gln
305                 310                 315                 320 
Lys Asp Asn Phe Leu Gly Leu Arg Gly Lys Ser Asp Pro Tyr Ala Lys
                325                 330                 335     
Val Ser Ile Gly Leu Gln His Phe Arg Ser Arg Thr Ile Tyr Arg Asn
            340                 345                 350         
Leu Asn Pro Thr Trp Asn Glu Val Phe Glu Phe Met Val Tyr Glu Val
        355                 360                 365             
Pro Gly Gln Asp Leu Glu Val Asp Leu Tyr Asp Glu Asp Thr Asp Arg
    370                 375                 380                 
Asp Asp Phe Leu Gly Ser Leu Gln Ile Cys Leu Gly Asp Val Met Thr
385                 390                 395                 400 
Asn Arg Val Val Asp Glu Trp Phe Val Leu Asn Asp Thr Thr Ser Gly
                405                 410                 415     
Arg Leu His Leu Arg Leu Glu Trp Leu Ser Leu Leu Thr Asp Gln Glu
            420                 425                 430         
Val Leu Thr Glu Asp His Gly Gly Leu Ser Thr Ala Ile Leu Val Val
        435                 440                 445             
Phe Leu Glu Ser Ala Cys Asn Leu Pro Arg Asn Pro Phe Asp Tyr Leu
    450                 455                 460                 
Asn Gly Glu Tyr Arg Ala Lys Lys Leu Ser Arg Phe Ala Arg Val Lys
465                 470                 475                 480 
Gln Gly Gln Gln Arg Pro Phe Phe Leu Cys Gln Thr Ile Cys Arg Gln
                485                 490                 495     
Glu Asp Thr Tyr Lys
            500     


<210> 6488
<211> 455
<212> PRT
<213> Homo sapiens

<400> 6488
Met Ser Phe Tyr Ser Lys Gln Asp Tyr Asn Met Asp Leu Glu Leu Asp
 1               5                  10                  15      
Glu Tyr Tyr Asn Lys Thr Leu Ala Thr Glu Asn Asn Thr Ala Ala Thr
            20                  25                  30          
Arg Asn Ser Asp Phe Pro Val Trp Asp Asp Tyr Lys Ser Ser Val Asp
        35                  40                  45              
Asp Leu Gln Tyr Phe Leu Ile Gly Leu Tyr Thr Phe Val Ser Leu Leu
    50                  55                  60                  
Gly Phe Met Gly Asn Leu Leu Ile Leu Met Ala Leu Met Lys Lys Arg
65                  70                  75                  80  
Asn Gln Lys Thr Thr Val Asn Phe Leu Ile Gly Asn Leu Ala Phe Ser
                85                  90                  95      
Asp Ile Leu Val Val Leu Phe Cys Ser Pro Phe Thr Leu Thr Ser Val
            100                 105                 110         
Leu Leu Asp Gln Trp Met Phe Gly Lys Val Met Cys His Ile Met Pro
        115                 120                 125             
Phe Leu Gln Cys Val Ser Val Leu Val Ser Thr Leu Ile Leu Ile Ser
    130                 135                 140                 
Ile Ala Ile Val Arg Tyr His Met Ile Lys His Pro Ile Ser Asn Asn
145                 150                 155                 160 
Leu Thr Ala Asn His Gly Tyr Phe Leu Ile Ala Thr Val Trp Thr Leu
                165                 170                 175     
Gly Phe Ala Ile Cys Ser Pro Leu Pro Val Phe His Ser Leu Val Glu
            180                 185                 190         
Leu Gln Glu Thr Phe Gly Ser Ala Leu Leu Ser Ser Arg Tyr Leu Cys
        195                 200                 205             
Val Glu Ser Trp Pro Ser Asp Ser Tyr Arg Ile Ala Phe Thr Ile Ser
    210                 215                 220                 
Leu Leu Leu Val Gln Tyr Ile Leu Pro Leu Val Cys Leu Thr Val Ser
225                 230                 235                 240 
His Thr Ser Val Cys Arg Ser Ile Ser Cys Gly Leu Ser Asn Lys Glu
                245                 250                 255     
Asn Arg Leu Glu Glu Asn Glu Met Ile Asn Leu Thr Leu His Pro Ser
            260                 265                 270         
Lys Lys Ser Gly Pro Gln Val Lys Leu Ser Gly Ser His Lys Trp Ser
        275                 280                 285             
Tyr Ser Phe Ile Lys Lys His Arg Arg Arg Tyr Ser Lys Lys Thr Ala
    290                 295                 300                 
Cys Val Leu Pro Ala Pro Glu Arg Pro Ser Gln Glu Asn His Ser Arg
305                 310                 315                 320 
Ile Leu Pro Glu Asn Phe Gly Ser Val Arg Ser Gln Leu Ser Ser Ser
                325                 330                 335     
Ser Lys Phe Ile Pro Gly Val Pro Thr Cys Phe Glu Ile Lys Pro Glu
            340                 345                 350         
Glu Asn Ser Asp Val His Glu Leu Arg Val Lys Arg Ser Val Thr Arg
        355                 360                 365             
Ile Lys Lys Arg Ser Arg Ser Val Phe Tyr Arg Leu Thr Ile Leu Ile
    370                 375                 380                 
Leu Val Phe Ala Val Ser Trp Met Pro Leu His Leu Phe His Val Val
385                 390                 395                 400 
Thr Asp Phe Asn Asp Asn Leu Ile Ser Asn Arg His Phe Lys Leu Val
                405                 410                 415     
Tyr Cys Ile Cys His Leu Leu Gly Met Met Ser Cys Cys Leu Asn Pro
            420                 425                 430         
Ile Leu Tyr Gly Phe Leu Asn Asn Gly Ile Lys Ala Asp Leu Val Ser
        435                 440                 445             
Leu Ile His Cys Leu His Met
    450                 455 


<210> 6489
<211> 862
<212> PRT
<213> Homo sapiens

<400> 6489
Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val
 1               5                  10                  15      
Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp
            20                  25                  30          
Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr
        35                  40                  45              
Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile
    50                  55                  60                  
Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu
65                  70                  75                  80  
Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys
                85                  90                  95      
Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile
            100                 105                 110         
Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr
        115                 120                 125             
Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys
    130                 135                 140                 
Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro
145                 150                 155                 160 
Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly
                165                 170                 175     
Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser
            180                 185                 190         
Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu
        195                 200                 205             
Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro
    210                 215                 220                 
Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val
225                 230                 235                 240 
Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val
                245                 250                 255     
Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr
            260                 265                 270         
Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu
        275                 280                 285             
Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu
    290                 295                 300                 
Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val
305                 310                 315                 320 
Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val
                325                 330                 335     
Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His
            340                 345                 350         
Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly
        355                 360                 365             
Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu
    370                 375                 380                 
Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met
385                 390                 395                 400 
Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys
                405                 410                 415     
Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp
            420                 425                 430         
Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu
        435                 440                 445             
His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr
    450                 455                 460                 
Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser
465                 470                 475                 480 
Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val
                485                 490                 495     
Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys
            500                 505                 510         
Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr
        515                 520                 525             
Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln
    530                 535                 540                 
Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser
545                 550                 555                 560 
Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys
                565                 570                 575     
Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Gly
            580                 585                 590         
Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn
        595                 600                 605             
Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys
    610                 615                 620                 
Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala
625                 630                 635                 640 
Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro
                645                 650                 655     
Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val
            660                 665                 670         
Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln
        675                 680                 685             
Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr
    690                 695                 700                 
Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu
705                 710                 715                 720 
His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu
                725                 730                 735     
Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe
            740                 745                 750         
Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg
        755                 760                 765             
Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp
    770                 775                 780                 
Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser
785                 790                 795                 800 
Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu
                805                 810                 815     
Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp
            820                 825                 830         
Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val
        835                 840                 845             
Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp
    850                 855                 860         


<210> 6490
<211> 862
<212> PRT
<213> Homo sapiens

<400> 6490
Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val
 1               5                  10                  15      
Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp
            20                  25                  30          
Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr
        35                  40                  45              
Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile
    50                  55                  60                  
Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu
65                  70                  75                  80  
Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys
                85                  90                  95      
Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile
            100                 105                 110         
Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr
        115                 120                 125             
Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys
    130                 135                 140                 
Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro
145                 150                 155                 160 
Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly
                165                 170                 175     
Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser
            180                 185                 190         
Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu
        195                 200                 205             
Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro
    210                 215                 220                 
Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val
225                 230                 235                 240 
Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val
                245                 250                 255     
Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr
            260                 265                 270         
Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu
        275                 280                 285             
Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu
    290                 295                 300                 
Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val
305                 310                 315                 320 
Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val
                325                 330                 335     
Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His
            340                 345                 350         
Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly
        355                 360                 365             
Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu
    370                 375                 380                 
Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met
385                 390                 395                 400 
Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys
                405                 410                 415     
Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp
            420                 425                 430         
Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu
        435                 440                 445             
His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr
    450                 455                 460                 
Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser
465                 470                 475                 480 
Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val
                485                 490                 495     
Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys
            500                 505                 510         
Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr
        515                 520                 525             
Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln
    530                 535                 540                 
Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser
545                 550                 555                 560 
Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys
                565                 570                 575     
Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Asp
            580                 585                 590         
Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn
        595                 600                 605             
Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys
    610                 615                 620                 
Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala
625                 630                 635                 640 
Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro
                645                 650                 655     
Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val
            660                 665                 670         
Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln
        675                 680                 685             
Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr
    690                 695                 700                 
Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu
705                 710                 715                 720 
His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu
                725                 730                 735     
Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe
            740                 745                 750         
Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg
        755                 760                 765             
Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp
    770                 775                 780                 
Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser
785                 790                 795                 800 
Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu
                805                 810                 815     
Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp
            820                 825                 830         
Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val
        835                 840                 845             
Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp
    850                 855                 860         


<210> 6491
<211> 513
<212> PRT
<213> Homo sapiens

<400> 6491
Lys Asn Lys Ile Ala Arg Leu Gly Asn Gly Ser Gln Asp Leu Asn His
 1               5                  10                  15      
Gly Val Asp Asn Glu Asn Gly Gly Arg Arg Gly Pro Asn Arg Thr Ser
            20                  25                  30          
Tyr Cys Arg Asn Pro Leu Cys Glu Pro Gly Ser Ser Gly Gly Ser Ser
        35                  40                  45              
Gly Ser His Thr Ser Ser Ala Ser Val Thr Ser Val Arg Ser Arg Thr
    50                  55                  60                  
Arg Ser Ser Ser Gly Thr Gly Leu Ser Ser Pro Pro Leu Ala Thr Gln
65                  70                  75                  80  
Thr Val Val Pro Leu Gln His Cys Lys Ile Pro Glu Leu Pro Val Gln
                85                  90                  95      
Ala Ser Ile Leu Phe Glu Leu Gln Leu Phe Phe Cys Gln Leu Ile Ala
            100                 105                 110         
Leu Phe Val His Tyr Ile Asn Ile Tyr Lys Thr Val Trp Trp Tyr Pro
        115                 120                 125             
Pro Ser His Pro Pro Ser His Thr Ser Leu Asn Phe His Leu Ile Asp
    130                 135                 140                 
Phe Asn Leu Leu Met Val Thr Thr Ile Val Leu Gly Arg Arg Phe Ile
145                 150                 155                 160 
Gly Ser Ile Val Lys Glu Ala Ser Gln Arg Gly Lys Val Ser Leu Phe
                165                 170                 175     
Arg Ser Ile Leu Leu Phe Leu Thr Arg Phe Thr Val Leu Thr Ala Thr
            180                 185                 190         
Gly Trp Ser Leu Cys Arg Ser Leu Ile His Leu Phe Arg Thr Tyr Ser
        195                 200                 205             
Phe Leu Asn Leu Leu Phe Leu Cys Tyr Pro Phe Gly Met Tyr Ile Pro
    210                 215                 220                 
Phe Leu Gln Leu Asn Cys Asp Leu Arg Lys Thr Ser Leu Phe Asn His
225                 230                 235                 240 
Met Ala Ser Met Gly Pro Arg Glu Ala Val Ser Gly Leu Ala Lys Ser
                245                 250                 255     
Arg Asp Tyr Leu Leu Thr Leu Arg Glu Thr Trp Lys Gln His Thr Arg
            260                 265                 270         
Gln Leu Tyr Gly Pro Asp Ala Met Pro Thr His Ala Cys Cys Leu Ser
        275                 280                 285             
Pro Ser Leu Ile Arg Ser Glu Val Glu Phe Leu Lys Met Asp Phe Asn
    290                 295                 300                 
Trp Arg Met Lys Glu Val Leu Val Ser Ser Met Leu Ser Ala Tyr Tyr
305                 310                 315                 320 
Val Ala Phe Val Pro Val Trp Phe Val Lys Asn Thr His Tyr Tyr Asp
                325                 330                 335     
Lys Arg Trp Ser Cys Glu Leu Phe Leu Leu Val Ser Ile Ser Thr Ser
            340                 345                 350         
Val Ile Leu Met Gln His Leu Leu Pro Ala Ser Tyr Cys Asp Leu Leu
        355                 360                 365             
His Lys Ala Ala Ala His Leu Gly Cys Trp Gln Lys Val Asp Pro Ala
    370                 375                 380                 
Leu Cys Ser Asn Val Leu Gln His Pro Trp Thr Glu Glu Cys Met Trp
385                 390                 395                 400 
Pro Gln Gly Val Leu Val Lys His Ser Lys Asn Val Tyr Lys Ala Val
                405                 410                 415     
Gly His Tyr Asn Val Ala Ile Pro Ser Asp Val Ser His Phe Arg Phe
            420                 425                 430         
His Phe Phe Phe Ser Lys Pro Leu Arg Ile Leu Asn Ile Leu Leu Leu
        435                 440                 445             
Leu Glu Gly Ala Val Ile Val Tyr Gln Leu Tyr Ser Leu Met Ser Ser
    450                 455                 460                 
Glu Lys Trp His Gln Thr Ile Ser Leu Ala Leu Ile Leu Phe Ser Asn
465                 470                 475                 480 
Tyr Tyr Ala Phe Phe Lys Leu Leu Arg Asp Arg Leu Val Leu Gly Lys
                485                 490                 495     
Ala Tyr Ser Tyr Ser Ala Ser Pro Gln Arg Asp Leu Asp His Arg Phe
            500                 505                 510         
Ser
    


<210> 6492
<211> 502
<212> PRT
<213> Homo sapiens

<400> 6492
Met Ala Ile His Leu Asp Lys Gln Asn Ile Ile Leu Lys Asn Asp Lys
 1               5                  10                  15      
Asp Glu Tyr Leu Lys Lys Thr Arg Asp Gly Val Leu Pro Pro Tyr Gln
            20                  25                  30          
Asp Ala Lys Pro Pro Ser Pro Ala Ser Ile Lys Lys Thr Tyr Thr Thr
        35                  40                  45              
Ser Lys Phe Asn Asp Ala Glu Pro Ala Lys Gly Asn Leu Phe Ile Gly
    50                  55                  60                  
Val Glu Val Leu Pro Glu Asn Leu His Leu Asp Glu Ser Glu Thr Ser
65                  70                  75                  80  
Glu Glu Asp His Gly Ser Leu Glu Lys Glu Lys Tyr Glu Gln Phe Leu
                85                  90                  95      
Ser Leu Glu Glu Gly Thr Lys Ala His Tyr Phe Phe Glu Lys Val Val
            100                 105                 110         
Asn Ala Ala Gln Thr Trp Phe Ser Leu Phe Gly Trp Pro Glu Gly Pro
        115                 120                 125             
His Ser Phe Ser Ile Pro Glu Thr Ile Arg Arg Asp Val Tyr Lys Met
    130                 135                 140                 
Gln Phe Tyr Ser Ser Thr Ser Pro Pro Gln Lys Phe Ser Arg Gln Asn
145                 150                 155                 160 
Asp Phe Ser Lys Tyr Asn Lys Thr Ile Tyr Asp Val Leu Leu His Leu
                165                 170                 175     
Ser Gly Lys Met Pro Pro Gly Ile Asn Ser Ser Gln Ser Leu Pro Val
            180                 185                 190         
Asp Asn His Glu Lys Arg Val Ile Gln Leu His Leu Gln His Ser Ser
        195                 200                 205             
Leu Leu Asp Phe Leu Asn Ala Gln Gly Gly Cys Ile Ser His Val Leu
    210                 215                 220                 
Pro Glu Phe Leu Leu Glu Pro Glu Asp Tyr Lys Arg Trp Ile Glu Ile
225                 230                 235                 240 
Met Ser Ser Thr Asn Thr Met Pro Val Ser Ser Cys Thr Pro Lys Lys
                245                 250                 255     
Lys Cys Ser Ile Val Ile Glu Met Ser Lys Phe Glu Ala Trp Ser Lys
            260                 265                 270         
Arg Ala Trp Thr Asp Val Phe Leu Gln Ile Tyr Lys Val Leu Val Leu
        275                 280                 285             
Ser Arg Val Val Pro Tyr Cys Ser Asn Asn Met Pro Pro Ile Cys Val
    290                 295                 300                 
Gln Asn Thr Pro Lys Val Asn Pro Cys Phe Ala Ser Ser Asn Ile Tyr
305                 310                 315                 320 
Ser Asp Ser Glu Arg Ile Leu Leu Ser Trp Met Asn Ile Asn Tyr Glu
                325                 330                 335     
Asn Thr Arg His Val Ile Trp Lys Asn Cys His Lys Asp Val Ile Pro
            340                 345                 350         
Ser Glu Arg Trp Ile Val Asn Phe Asp Lys Asp Leu Ser Asp Gly Leu
        355                 360                 365             
Val Phe Ala Thr Gln Leu Gly Ala Tyr Cys Pro Phe Leu Ile Glu Ser
    370                 375                 380                 
His Phe Ile Asn Met Tyr Thr Arg Pro Lys Ser Pro Glu Glu Tyr Leu
385                 390                 395                 400 
His Asn Cys Leu Ile Ile Val Asn Thr Leu Tyr Glu Ile Asp Phe Asp
                405                 410                 415     
Val Glu Ile Gln Val Cys Leu Arg Val Phe Pro Lys Glu Met Asp Ala
            420                 425                 430         
Gly Val Ser Gly Leu Arg Lys Glu Asp Met Pro Ser Val Trp Val Val
        435                 440                 445             
Thr Ile Arg Leu Ala Val Ala Val Ala Arg Thr Lys Arg Gln Lys Lys
    450                 455                 460                 
Gly Asp Ile Gln Phe Ala Cys Phe Phe Val Cys Leu Phe Phe Phe Ile
465                 470                 475                 480 
Phe Val Val Ile Ser Phe Ser Leu Trp Ser Arg Met His Phe Phe Leu
                485                 490                 495     
Leu Leu Pro Leu Asp Ile
            500         


<210> 6493
<211> 492
<212> PRT
<213> Homo sapiens

<400> 6493
Met Val Lys Phe Pro Ala Leu Thr His Tyr Trp Pro Leu Ile Arg Phe
 1               5                  10                  15      
Leu Val Pro Leu Gly Ile Thr Asn Ile Ala Ile Asp Phe Gly Glu Gln
            20                  25                  30          
Ala Leu Asn Arg Gly Ile Ala Ala Val Lys Glu Asp Ala Val Glu Met
        35                  40                  45              
Leu Ala Ser Tyr Gly Leu Ala Tyr Ser Leu Met Lys Phe Phe Thr Gly
    50                  55                  60                  
Pro Met Ser Asp Phe Lys Asn Val Gly Leu Val Phe Val Asn Ser Lys
65                  70                  75                  80  
Arg Asp Arg Thr Lys Ala Val Leu Cys Met Val Val Ala Gly Ala Ile
                85                  90                  95      
Ala Ala Val Phe His Thr Leu Ile Ala Tyr Ser Asp Leu Gly Tyr Tyr
            100                 105                 110         
Ile Ile Asn Lys Leu His His Val Asp Glu Ser Val Gly Ser Lys Thr
        115                 120                 125             
Arg Arg Ala Phe Leu Tyr Leu Ala Ala Phe Pro Phe Met Asp Ala Met
    130                 135                 140                 
Ala Trp Thr His Ala Gly Ile Leu Leu Lys His Lys Tyr Ser Phe Leu
145                 150                 155                 160 
Val Gly Cys Ala Ser Ile Ser Asp Val Ile Ala Gln Val Val Phe Val
                165                 170                 175     
Ala Ile Leu Leu His Ser His Leu Glu Cys Arg Glu Pro Leu Leu Ile
            180                 185                 190         
Pro Ile Leu Ser Leu Tyr Met Gly Ala Leu Val Arg Cys Thr Thr Leu
        195                 200                 205             
Cys Leu Gly Tyr Tyr Lys Asn Ile His Asp Ile Ile Pro Asp Arg Ser
    210                 215                 220                 
Gly Pro Glu Leu Gly Gly Asp Ala Thr Ile Arg Lys Met Leu Ser Phe
225                 230                 235                 240 
Trp Trp Pro Leu Ala Leu Ile Leu Ala Thr Gln Arg Ile Ser Arg Pro
                245                 250                 255     
Ile Val Asn Leu Phe Val Ser Arg Asp Leu Gly Gly Ser Ser Ala Ala
            260                 265                 270         
Thr Glu Ala Val Ala Ile Leu Thr Ala Thr Tyr Pro Val Gly His Met
        275                 280                 285             
Pro Tyr Gly Trp Leu Thr Glu Ile Arg Ala Val Tyr Pro Ala Phe Asp
    290                 295                 300                 
Lys Asn Asn Pro Ser Asn Lys Leu Val Ser Thr Ser Asn Thr Val Thr
305                 310                 315                 320 
Ala Ala His Ile Lys Lys Phe Thr Phe Val Cys Met Ala Leu Ser Leu
                325                 330                 335     
Thr Leu Cys Phe Val Met Phe Trp Thr Pro Asn Val Ser Glu Lys Ile
            340                 345                 350         
Leu Ile Asp Ile Ile Gly Val Asp Phe Ala Phe Ala Glu Leu Cys Val
        355                 360                 365             
Val Pro Leu Arg Ile Phe Ser Phe Phe Pro Val Pro Val Thr Val Arg
    370                 375                 380                 
Ala His Leu Thr Gly Trp Leu Met Thr Leu Lys Lys Thr Phe Val Leu
385                 390                 395                 400 
Ala Pro Ser Ser Val Leu Arg Ile Ile Val Leu Ile Ala Ser Leu Val
                405                 410                 415     
Val Leu Pro Tyr Leu Gly Val His Gly Ala Thr Leu Gly Val Gly Ser
            420                 425                 430         
Leu Leu Ala Gly Phe Val Gly Glu Ser Thr Met Val Ala Ile Ala Ala
        435                 440                 445             
Cys Tyr Val Tyr Arg Lys Gln Lys Lys Lys Met Glu Asn Glu Ser Ala
    450                 455                 460                 
Thr Glu Gly Glu Asp Ser Ala Met Thr Asp Met Pro Pro Thr Glu Glu
465                 470                 475                 480 
Val Thr Asp Ile Val Glu Met Arg Glu Glu Asn Glu
                485                 490         


<210> 6494
<211> 627
<212> PRT
<213> Homo sapiens

<400> 6494
Met Glu Leu Gly Gly Pro Gly Ala Pro Arg Leu Leu Pro Pro Leu Leu
 1               5                  10                  15      
Leu Leu Leu Gly Thr Gly Leu Leu Arg Ala Ser Ser His Val Glu Thr
            20                  25                  30          
Arg Ala His Ala Glu Glu Arg Leu Leu Lys Lys Leu Phe Ser Gly Tyr
        35                  40                  45              
Asn Lys Trp Ser Arg Pro Val Ala Asn Ile Ser Asp Val Val Leu Val
    50                  55                  60                  
Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn
65                  70                  75                  80  
Gln Met Met Thr Thr Asn Val Trp Val Lys Gln Glu Trp His Asp Tyr
                85                  90                  95      
Lys Leu Arg Trp Asp Pro Ala Asp Tyr Glu Asn Val Thr Ser Ile Arg
            100                 105                 110         
Ile Pro Ser Glu Leu Ile Trp Arg Pro Asp Ile Val Leu Tyr Asn Asn
        115                 120                 125             
Ala Asp Gly Asp Phe Ala Val Thr His Leu Thr Lys Ala His Leu Phe
    130                 135                 140                 
His Asp Gly Arg Val Gln Trp Thr Pro Pro Ala Ile Tyr Lys Ser Ser
145                 150                 155                 160 
Cys Ser Ile Asp Val Thr Phe Phe Pro Phe Asp Gln Gln Asn Cys Thr
                165                 170                 175     
Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys Ala Lys Ile Asp Leu Val
            180                 185                 190         
Asn Met His Ser Arg Val Asp Gln Leu Asp Phe Trp Glu Ser Gly Glu
        195                 200                 205             
Trp Val Ile Val Asp Ala Val Gly Thr Tyr Asn Thr Arg Lys Tyr Glu
    210                 215                 220                 
Cys Cys Ala Glu Ile Tyr Pro Asp Ile Thr Tyr Ala Phe Val Ile Arg
225                 230                 235                 240 
Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu
                245                 250                 255     
Ile Ser Cys Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Glu Cys Gly
            260                 265                 270         
Glu Lys Ile Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe
        275                 280                 285             
Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser Thr Ser Leu Val Ile Pro
    290                 295                 300                 
Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser
305                 310                 315                 320 
Ile Val Ile Thr Val Phe Val Leu Asn Val His His Arg Ser Pro Arg
                325                 330                 335     
Thr His Thr Met Pro Thr Trp Val Arg Arg Val Phe Leu Asp Ile Val
            340                 345                 350         
Pro Arg Leu Leu Leu Met Lys Arg Pro Ser Val Val Lys Asp Asn Cys
        355                 360                 365             
Arg Arg Leu Ile Glu Ser Met His Lys Met Ala Ser Ala Pro Arg Phe
    370                 375                 380                 
Trp Pro Glu Pro Glu Gly Glu Pro Pro Ala Thr Ser Gly Thr Gln Ser
385                 390                 395                 400 
Leu His Pro Pro Ser Pro Ser Phe Cys Val Pro Leu Asp Val Pro Ala
                405                 410                 415     
Glu Pro Gly Pro Ser Cys Lys Ser Pro Ser Asp Gln Leu Pro Pro Gln
            420                 425                 430         
Gln Pro Leu Glu Ala Glu Lys Ala Ser Pro His Pro Ser Pro Gly Pro
        435                 440                 445             
Cys Arg Pro Pro His Gly Thr Gln Ala Pro Gly Leu Ala Lys Ala Arg
    450                 455                 460                 
Ser Leu Ser Val Gln His Met Ser Ser Pro Gly Glu Ala Val Glu Gly
465                 470                 475                 480 
Gly Val Arg Cys Arg Ser Arg Ser Ile Gln Tyr Cys Val Pro Arg Asp
                485                 490                 495     
Asp Ala Ala Pro Glu Ala Asp Gly Gln Ala Ala Gly Ala Leu Ala Ser
            500                 505                 510         
Arg Asn Thr His Ser Ala Glu Leu Pro Pro Pro Asp Gln Pro Ser Pro
        515                 520                 525             
Cys Lys Cys Thr Cys Lys Lys Glu Pro Ser Ser Val Ser Pro Ser Ala
    530                 535                 540                 
Thr Val Lys Thr Arg Ser Thr Lys Ala Pro Pro Pro His Leu Pro Leu
545                 550                 555                 560 
Ser Pro Ala Leu Thr Arg Ala Val Glu Gly Val Gln Tyr Ile Ala Asp
                565                 570                 575     
His Leu Lys Ala Glu Asp Thr Asp Phe Ser Val Lys Glu Asp Trp Lys
            580                 585                 590         
Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Met Phe Ile Ile
        595                 600                 605             
Val Cys Leu Leu Gly Thr Val Gly Leu Phe Leu Pro Pro Trp Leu Ala
    610                 615                 620                 
Gly Met Ile
625         


<210> 6495
<211> 486
<212> PRT
<213> Homo sapiens

<400> 6495
Met Ala Lys Val Asn Arg Ala Arg Ser Thr Ser Pro Pro Asp Gly Gly
 1               5                  10                  15      
Trp Gly Trp Met Ile Val Ala Gly Cys Phe Leu Val Thr Ile Cys Thr
            20                  25                  30          
Arg Ala Val Thr Arg Cys Ile Ser Ile Phe Phe Val Glu Phe Gln Thr
        35                  40                  45              
Tyr Phe Thr Gln Asp Tyr Ala Gln Thr Ala Trp Ile His Ser Ile Val
    50                  55                  60                  
Asp Cys Val Thr Met Leu Cys Ala Pro Leu Gly Ser Val Val Ser Asn
65                  70                  75                  80  
His Leu Ser Cys Gln Val Gly Ile Met Leu Gly Gly Leu Leu Ala Ser
                85                  90                  95      
Thr Gly Leu Ile Leu Ser Ser Phe Ala Thr Ser Leu Lys His Leu Tyr
            100                 105                 110         
Leu Thr Leu Gly Val Leu Thr Gly Leu Gly Phe Ala Leu Cys Tyr Ser
        115                 120                 125             
Pro Ala Ile Ala Met Val Gly Lys Tyr Phe Ser Arg Arg Lys Ala Leu
    130                 135                 140                 
Ala Tyr Gly Ile Ala Met Ser Gly Ser Gly Ile Gly Thr Phe Ile Leu
145                 150                 155                 160 
Ala Pro Val Val Gln Leu Leu Ile Glu Gln Phe Ser Trp Arg Gly Ala
                165                 170                 175     
Leu Leu Ile Leu Gly Gly Phe Val Leu Asn Leu Cys Val Cys Gly Ala
            180                 185                 190         
Leu Met Arg Pro Ile Thr Leu Lys Glu Asp His Thr Thr Pro Glu Gln
        195                 200                 205             
Asn His Val Cys Arg Thr Gln Lys Glu Asp Ile Lys Arg Val Ser Pro
    210                 215                 220                 
Tyr Ser Ser Leu Thr Lys Glu Trp Ala Gln Thr Cys Leu Cys Cys Cys
225                 230                 235                 240 
Leu Gln Gln Glu Tyr Ser Phe Leu Leu Met Ser Asp Phe Val Val Leu
                245                 250                 255     
Ala Val Ser Val Leu Phe Met Ala Tyr Gly Cys Ser Pro Leu Phe Val
            260                 265                 270         
Tyr Leu Val Pro Tyr Ala Leu Ser Val Gly Val Ser His Gln Gln Ala
        275                 280                 285             
Ala Phe Leu Met Ser Ile Leu Gly Val Ile Asp Ile Ile Gly Asn Ile
    290                 295                 300                 
Thr Phe Gly Trp Leu Thr Asp Arg Arg Cys Leu Lys Asn Tyr Gln Tyr
305                 310                 315                 320 
Val Cys Tyr Leu Phe Ala Val Gly Met Asp Gly Leu Cys Tyr Leu Cys
                325                 330                 335     
Leu Pro Met Leu Gln Ser Leu Pro Leu Leu Val Pro Phe Ser Cys Thr
            340                 345                 350         
Phe Gly Tyr Phe Asp Gly Ala Tyr Val Thr Leu Ile Pro Val Val Thr
        355                 360                 365             
Thr Glu Ile Val Gly Thr Thr Ser Leu Ser Ser Ala Leu Gly Val Val
    370                 375                 380                 
Tyr Phe Leu His Ala Val Pro Tyr Leu Val Ser Pro Pro Ile Ala Gly
385                 390                 395                 400 
Arg Leu Val Asp Thr Thr Gly Ser Tyr Thr Ala Ala Phe Leu Leu Cys
                405                 410                 415     
Gly Phe Ser Met Ile Phe Ser Ser Val Leu Leu Gly Phe Ala Arg Leu
            420                 425                 430         
Ile Lys Arg Met Arg Lys Thr Gln Leu Gln Phe Ile Ala Lys Glu Ser
        435                 440                 445             
Asp Pro Lys Leu Gln Leu Trp Thr Asn Gly Ser Val Ala Tyr Ser Val
    450                 455                 460                 
Ala Arg Glu Leu Asp Gln Lys His Gly Glu Pro Val Ala Thr Ala Val
465                 470                 475                 480 
Pro Gly Tyr Ser Leu Thr
                485     


<210> 6496
<211> 1083
<212> PRT
<213> Homo sapiens

<400> 6496
Met Arg Asp Asn Glu Lys Ala Trp Trp Gln Gln Trp Thr Ser His Thr
 1               5                  10                  15      
Gly Leu Glu Gly Trp Gly Gly Thr Gln Glu Asp Arg Met Gly Phe Gly
            20                  25                  30          
Gly Ala Val Ala Ala Leu Arg Gly Arg Pro Ser Pro Leu Gln Ser Thr
        35                  40                  45              
Ile His Glu Ser Tyr Gly Arg Pro Glu Glu Gln Val Leu Ile Asn Arg
    50                  55                  60                  
Gln Glu Ile Thr Asn Lys Ala Asp Ala Trp Asp Met Gln Glu Phe Ile
65                  70                  75                  80  
Thr His Met Tyr Ile Lys Gln Leu Leu Arg His Pro Ala Phe Gln Leu
                85                  90                  95      
Leu Leu Ala Leu Leu Leu Val Ile Asn Ala Ile Thr Ile Ala Leu Arg
            100                 105                 110         
Thr Asn Ser Tyr Leu Asp Gln Lys His Tyr Glu Leu Phe Ser Thr Ile
        115                 120                 125             
Asp Asp Ile Val Leu Thr Ile Leu Leu Cys Glu Val Leu Leu Gly Trp
    130                 135                 140                 
Leu Asn Gly Phe Trp Ile Phe Trp Lys Asp Gly Trp Asn Ile Leu Asn
145                 150                 155                 160 
Phe Ile Ile Val Phe Ile Leu Leu Leu Arg Phe Phe Ile Asn Glu Ile
                165                 170                 175     
Asn Ile Pro Ser Ile Asn Tyr Thr Leu Arg Ala Leu Arg Leu Val His
            180                 185                 190         
Val Cys Met Ala Val Glu Pro Leu Ala Arg Ile Ile Arg Val Ile Leu
        195                 200                 205             
Gln Ser Val Pro Asp Met Ala Asn Ile Met Val Leu Ile Leu Phe Phe
    210                 215                 220                 
Met Leu Val Phe Ser Val Phe Gly Val Thr Leu Phe Gly Ala Phe Val
225                 230                 235                 240 
Pro Lys His Phe Gln Asn Ile Gln Val Ala Leu Tyr Thr Leu Phe Ile
                245                 250                 255     
Cys Ile Thr Gln Asp Gly Trp Val Asp Ile Tyr Ser Asp Phe Gln Thr
            260                 265                 270         
Glu Lys Arg Glu Tyr Ala Met Glu Ile Gly Gly Ala Ile Tyr Phe Thr
        275                 280                 285             
Ile Phe Ile Thr Ile Gly Ala Phe Ile Gly Ile Asn Leu Phe Val Ile
    290                 295                 300                 
Val Val Thr Thr Asn Leu Glu Gln Met Met Lys Ala Gly Glu Gln Gly
305                 310                 315                 320 
Gln Gln Gln Arg Ile Thr Phe Ser Glu Thr Gly Ala Glu Glu Glu Glu
                325                 330                 335     
Glu Asn Asp Gln Leu Pro Leu Val His Cys Val Val Ala Arg Ser Glu
            340                 345                 350         
Lys Ser Gly Leu Leu Gln Glu Pro Leu Ala Gly Gly Pro Leu Ser Asn
        355                 360                 365             
Leu Ser Glu Asn Thr Cys Asp Asn Phe Cys Leu Val Leu Glu Ala Ile
    370                 375                 380                 
Gln Glu Asn Leu Arg Gln Tyr Lys Glu Ile Arg Asp Glu Leu Asn Met
385                 390                 395                 400 
Ile Val Glu Glu Val Arg Ala Ile Arg Phe Asn Gln Glu Gln Glu Ser
                405                 410                 415     
Glu Val Leu Asn Arg Arg Ser Ser Thr Ser Gly Ser Leu Glu Thr Thr
            420                 425                 430         
Ser Ser Lys Asp Ile Arg Gln Met Ser Gln Gln Gln Asp Leu Leu Ser
        435                 440                 445             
Ala Leu Val Ser Met Glu Lys Asp Phe Phe Pro Ala Pro Ser Arg Thr
    450                 455                 460                 
Ile Ser Ser Thr Glu Lys Gly Thr Gln Arg Ile Leu Leu Leu Leu Leu
465                 470                 475                 480 
Leu Leu Thr Gly Asp Gly Ala Leu Asn Leu Pro Glu Ala Tyr Asn Thr
                485                 490                 495     
Ser Cys Ser Ser Asn Leu Ser Thr Asn Ser Ser Ser Asn Gly Ser Thr
            500                 505                 510         
Glu Gln Thr Thr Ser Ile Gln Lys Thr Gln Glu Glu Lys Leu Asn Thr
        515                 520                 525             
Thr Ile Ser Thr Thr Ser Lys Gly Thr Leu Leu Pro Asn Ser Ile Met
    530                 535                 540                 
Thr Ser Thr Leu Lys Asp Gln Gly Gly Ile Ser Arg Thr Thr Ala Leu
545                 550                 555                 560 
Ser Ser Thr Ala Ser Ser Val Glu Thr Pro Lys Gln Asn Gln Glu Thr
                565                 570                 575     
Pro Ile Ile Thr Pro Ser Ala Ser Asn Thr Thr Val Asn Gly Thr Gln
            580                 585                 590         
Ser Ser Val Ser Ile Gly Phe Gln Glu Ser Asp Thr Ile Thr Ser Pro
        595                 600                 605             
Thr Ala Leu Asn Thr Pro Gly Ser Asp Val Gln Ser Ser Gly Ser Met
    610                 615                 620                 
Ala Thr Thr Val Ser Gly Lys Ser Ala Ile Thr Thr Ser Pro Thr Ala
625                 630                 635                 640 
Lys Ser Thr Pro Gly His His Val Gln Ser Ser Gly Ser Met Ala Thr
                645                 650                 655     
Thr Val Ser Gly Lys Ser Ala Ile Thr Thr Ser Pro Thr Ala Leu Asn
            660                 665                 670         
Lys Thr Thr Gly Ile Lys Glu Ser Ser Pro Met Thr Ala Ser Glu Val
        675                 680                 685             
Met His Thr Thr Leu Leu Asn Thr Thr Thr Leu Gly Thr Thr Leu Leu
    690                 695                 700                 
Gly Thr Thr Thr Ser Glu Thr Gln Glu Gly Lys Thr Thr Ala Ala Ser
705                 710                 715                 720 
Leu Ser Pro Thr Thr Thr Ser Met Ile Ser Lys Leu Ser Gly Thr His
                725                 730                 735     
His Asn Thr Val Ser Gln Thr Pro Ser His Leu Ala Glu Ser Thr Ser
            740                 745                 750         
Ser Val Ala Thr Ala Ile Ile Gln Ser His Glu Met Thr Ala Ala His
        755                 760                 765             
Ser Thr Gly Leu Leu Pro Arg Ser Ser Glu Thr Thr Lys Ser Ser Ala
    770                 775                 780                 
Val Thr Gly Ala Ser Gln Thr Ser Pro Lys His Thr Gln Ser Ser Gly
785                 790                 795                 800 
Pro Arg Val Gly Ala Cys Ala Leu Asp Glu Tyr Ala Gly Ser Arg Gly
                805                 810                 815     
Val Cys Met Cys Asn Asp Ser Tyr Tyr Phe His Ala Glu Leu Ser Arg
            820                 825                 830         
Val Ser Val Ser Leu His Cys Trp Pro Gln Lys Ile Glu Val Val Leu
        835                 840                 845             
Ser Ser Cys Ile Leu Gln Thr Arg Arg Trp Met Leu Met Lys Asp Ala
    850                 855                 860                 
Phe Ser Gly Cys Ser Ser Ile Ser Lys Ile Glu Gln Gly Leu Arg Val
865                 870                 875                 880 
Gln Val Phe Leu Leu Glu Lys Lys Glu Gly Thr Cys Gly Leu Arg Leu
                885                 890                 895     
Ser Thr Asn Ser Ser His Ala Leu Tyr Ser Leu Glu Val Gln Leu Leu
            900                 905                 910         
Gln Val Leu Pro Gly Phe Ile Ser Asn Asp Ser Thr Met Leu Ser Phe
        915                 920                 925             
Ser Cys Thr Tyr Thr Leu Val Val Asn Val Ser Gln Thr His Pro Tyr
    930                 935                 940                 
Gln Val Phe Ser Phe Pro Tyr Ser Thr Ile His Val Leu Gly Thr Gly
945                 950                 955                 960 
Asp Thr Ile Ile Ile Leu Gly Ile Phe Thr Asp Leu Gln Leu Leu Thr
                965                 970                 975     
Leu Leu Glu Asn Arg Thr Val Pro Leu Gly Met Pro Phe Tyr Val Val
            980                 985                 990         
Leu Lys Thr Ile Ser Ser Asp Leu Pro Trp Cys Cys Pro Val Ser Asn
        995                 1000                1005            
Arg Leu Leu Gln Gly Leu Arg Ala Asn Gly Ala Ser Leu Glu Val Thr
    1010                1015                1020                
Leu Ala Phe Asn Leu Ile Arg Phe Ser Thr Ser Asp Thr Leu Tyr Leu
1025                1030                1035                1040
His Gly Arg Val Thr Leu Cys Asp Thr Arg Ala Arg Arg Pro Cys Gln
                1045                1050                1055    
Pro Val Ser Gly Gln Pro Arg Asp Leu Leu Arg Ser Arg Arg Ser Leu
            1060                1065                1070        
Ala Cys Lys Ala Val Pro Ala Gly Gln Ala Gly
        1075                1080            


<210> 6497
<211> 1256
<212> PRT
<213> Homo sapiens

<400> 6497
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15      
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly
            20                  25                  30          
Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu
        35                  40                  45              
Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu
    50                  55                  60                  
Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser
65                  70                  75                  80  
Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr
                85                  90                  95      
Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp
            100                 105                 110         
Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser
        115                 120                 125             
Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser
    130                 135                 140                 
Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly
145                 150                 155                 160 
Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro
                165                 170                 175     
Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn
            180                 185                 190         
Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val
        195                 200                 205             
Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr
    210                 215                 220                 
Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala
225                 230                 235                 240 
Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe
                245                 250                 255     
Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys
            260                 265                 270         
Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile
        275                 280                 285             
Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile
    290                 295                 300                 
Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu
305                 310                 315                 320 
Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys
                325                 330                 335     
Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser
            340                 345                 350         
Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser
        355                 360                 365             
Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys
    370                 375                 380                 
Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys
385                 390                 395                 400 
Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys
                405                 410                 415     
Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser
            420                 425                 430         
Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp
        435                 440                 445             
Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro
    450                 455                 460                 
His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg
465                 470                 475                 480 
Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr
                485                 490                 495     
Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro
            500                 505                 510         
Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala
        515                 520                 525             
Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu
    530                 535                 540                 
Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys
545                 550                 555                 560 
Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln
                565                 570                 575     
Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr
            580                 585                 590         
Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln
        595                 600                 605             
Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys
    610                 615                 620                 
Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp
625                 630                 635                 640 
Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn
                645                 650                 655     
Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr
            660                 665                 670         
Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg
        675                 680                 685             
Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys
    690                 695                 700                 
Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu
705                 710                 715                 720 
Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His
                725                 730                 735     
Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys
            740                 745                 750         
Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser
        755                 760                 765             
Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu
    770                 775                 780                 
Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val
785                 790                 795                 800 
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile
                805                 810                 815     
Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr
            820                 825                 830         
Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val
        835                 840                 845             
Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln
    850                 855                 860                 
Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His
865                 870                 875                 880 
Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala
                885                 890                 895     
Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile
            900                 905                 910         
Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile
        915                 920                 925             
Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser
    930                 935                 940                 
Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp
945                 950                 955                 960 
Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr
                965                 970                 975     
Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr
            980                 985                 990         
Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile
        995                 1000                1005            
Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln
    1010                1015                1020                
Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu
1025                1030                1035                1040
Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu
                1045                1050                1055    
Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr
            1060                1065                1070        
Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile
        1075                1080                1085            
Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser
    1090                1095                1100                
Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg
1105                1110                1115                1120
Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu
                1125                1130                1135    
Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys
            1140                1145                1150        
Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr
        1155                1160                1165            
Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly
    1170                1175                1180                
Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn
1185                1190                1195                1200
Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly
                1205                1210                1215    
Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu
            1220                1225                1230        
Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala
        1235                1240                1245            
Ser Pro Ala Leu Asn Gln Gly Ser
    1250                1255    


<210> 6498
<211> 2257
<212> PRT
<213> Homo sapiens

<400> 6498
Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln
 1               5                  10                  15      
Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala
            20                  25                  30          
Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala
        35                  40                  45              
Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu
    50                  55                  60                  
Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln
65                  70                  75                  80  
Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr
                85                  90                  95      
Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro
            100                 105                 110         
Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile
        115                 120                 125             
Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr
    130                 135                 140                 
Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu
145                 150                 155                 160 
Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu
                165                 170                 175     
Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg
            180                 185                 190         
Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe
        195                 200                 205             
Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu
    210                 215                 220                 
Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg
225                 230                 235                 240 
Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val
                245                 250                 255     
Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala
            260                 265                 270         
Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu
        275                 280                 285             
Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile
    290                 295                 300                 
Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr
305                 310                 315                 320 
Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp
                325                 330                 335     
Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala
            340                 345                 350         
Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val
        355                 360                 365             
Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr
    370                 375                 380                 
Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val
385                 390                 395                 400 
Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys
                405                 410                 415     
Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu
            420                 425                 430         
Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp
        435                 440                 445             
Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met
    450                 455                 460                 
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala
465                 470                 475                 480 
Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg
                485                 490                 495     
Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe
            500                 505                 510         
Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp
        515                 520                 525             
Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu
    530                 535                 540                 
His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn
545                 550                 555                 560 
Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr
                565                 570                 575     
Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp
            580                 585                 590         
Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr
        595                 600                 605             
Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu
    610                 615                 620                 
Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu
625                 630                 635                 640 
Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu
                645                 650                 655     
Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu
            660                 665                 670         
Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr
        675                 680                 685             
Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr
    690                 695                 700                 
Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly
705                 710                 715                 720 
Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu
                725                 730                 735     
Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala
            740                 745                 750         
Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu
        755                 760                 765             
Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro
    770                 775                 780                 
Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys
785                 790                 795                 800 
Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro
                805                 810                 815     
Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu
            820                 825                 830         
Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu
        835                 840                 845             
Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu
    850                 855                 860                 
Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe
865                 870                 875                 880 
Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile
                885                 890                 895     
Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu
            900                 905                 910         
Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe
        915                 920                 925             
Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe
    930                 935                 940                 
Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe
945                 950                 955                 960 
Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly
                965                 970                 975     
Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu
            980                 985                 990         
Asp Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser
        995                 1000                1005            
Ser Ala Ile Asn Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg
    1010                1015                1020                
Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln
1025                1030                1035                1040
Cys Val Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Val Ile Val Thr
                1045                1050                1055    
Thr Leu Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys
            1060                1065                1070        
Gly Lys Leu Tyr Thr Cys Ser Asp Ser Ser Lys Gln Thr Glu Ala Glu
        1075                1080                1085            
Cys Lys Gly Asn Tyr Ile Thr Tyr Lys Asp Gly Glu Val Asp His Pro
    1090                1095                1100                
Ile Ile Gln Pro Arg Ser Trp Glu Asn Ser Lys Phe Asp Phe Asp Asn
1105                1110                1115                1120
Val Leu Ala Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly
                1125                1130                1135    
Trp Pro Glu Leu Leu Tyr Arg Ser Ile Asp Ser His Thr Glu Asp Lys
            1140                1145                1150        
Gly Pro Ile Tyr Asn Tyr Arg Val Glu Ile Ser Ile Phe Phe Ile Ile
        1155                1160                1165            
Tyr Ile Ile Ile Ile Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe
    1170                1175                1180                
Val Ile Val Thr Phe Gln Glu Gln Gly Glu Gln Glu Tyr Lys Asn Cys
1185                1190                1195                1200
Glu Leu Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala
                1205                1210                1215    
Arg Pro Leu Arg Arg Tyr Ile Pro Lys Asn Gln His Gln Tyr Lys Val
            1220                1225                1230        
Trp Tyr Val Val Asn Ser Thr Tyr Phe Glu Tyr Leu Met Phe Val Leu
        1235                1240                1245            
Ile Leu Leu Asn Thr Ile Cys Leu Ala Met Gln His Tyr Gly Gln Ser
    1250                1255                1260                
Cys Leu Phe Lys Ile Ala Met Asn Ile Leu Asn Met Leu Phe Thr Gly
1265                1270                1275                1280
Leu Phe Thr Val Glu Met Ile Leu Lys Leu Ile Ala Phe Lys Pro Lys
                1285                1290                1295    
Gly Tyr Phe Ser Asp Pro Trp Asn Val Phe Asp Phe Leu Ile Val Ile
            1300                1305                1310        
Gly Ser Ile Ile Asp Val Ile Leu Ser Glu Thr Asn His Tyr Phe Cys
        1315                1320                1325            
Asp Ala Trp Asn Thr Phe Asp Ala Leu Ile Val Val Gly Ser Ile Val
    1330                1335                1340                
Asp Ile Ala Ile Thr Glu Val Asn Pro Ala Glu His Thr Gln Cys Ser
1345                1350                1355                1360
Pro Ser Met Asn Ala Glu Glu Asn Ser Arg Ile Ser Ile Thr Phe Phe
                1365                1370                1375    
Arg Leu Phe Arg Val Met Arg Leu Val Lys Leu Leu Ser Arg Gly Glu
            1380                1385                1390        
Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile Lys Ser Phe Gln Ala Leu
        1395                1400                1405            
Pro Tyr Val Ala Leu Leu Ile Val Met Leu Phe Phe Ile Tyr Ala Val
    1410                1415                1420                
Ile Gly Met Gln Val Phe Gly Lys Ile Ala Leu Asn Asp Thr Thr Glu
1425                1430                1435                1440
Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe Pro Gln Ala Val Leu Leu
                1445                1450                1455    
Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp Gln Asp Ile Met Leu Ala
            1460                1465                1470        
Cys Met Pro Gly Lys Lys Cys Ala Pro Glu Ser Glu Pro Ser Asn Ser
        1475                1480                1485            
Thr Glu Gly Glu Thr Pro Cys Gly Ser Ser Phe Ala Val Phe Tyr Phe
    1490                1495                1500                
Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile Asn Leu Phe Val
1505                1510                1515                1520
Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile
                1525                1530                1535    
Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile Trp Ala Glu Tyr
            1540                1545                1550        
Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp Val Val Thr Leu
        1555                1560                1565            
Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys Leu Cys Pro His
    1570                1575                1580                
Arg Val Ala Cys Lys Arg Leu Val Ser Met Asn Met Pro Leu Asn Ser
1585                1590                1595                1600
Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala Leu Val Arg Thr
                1605                1610                1615    
Ala Leu Arg Ile Lys Thr Glu Gly Asn Leu Glu Gln Ala Asn Glu Glu
            1620                1625                1630        
Leu Arg Ala Ile Ile Lys Lys Ile Trp Lys Arg Thr Ser Met Lys Leu
        1635                1640                1645            
Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu Val Thr Val Gly
    1650                1655                1660                
Lys Phe Tyr Ala Thr Phe Leu Ile Gln Glu Tyr Phe Arg Lys Phe Lys
1665                1670                1675                1680
Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Pro Ser Gln Arg Asn Ala
                1685                1690                1695    
Leu Ser Leu Gln Ala Gly Leu Arg Thr Leu His Asp Ile Gly Pro Glu
            1700                1705                1710        
Ile Arg Arg Ala Ile Ser Gly Asp Leu Thr Ala Glu Glu Glu Leu Asp
        1715                1720                1725            
Lys Ala Met Lys Glu Ala Val Ser Ala Ala Ser Glu Asp Asp Ile Phe
    1730                1735                1740                
Arg Arg Ala Gly Gly Leu Phe Gly Asn His Val Ser Tyr Tyr Gln Ser
1745                1750                1755                1760
Asp Gly Arg Ser Ala Phe Pro Gln Thr Phe Thr Thr Gln Arg Pro Leu
                1765                1770                1775    
His Ile Asn Lys Ala Gly Ser Ser Gln Gly Asp Thr Glu Ser Pro Ser
            1780                1785                1790        
His Glu Lys Leu Val Asp Ser Thr Phe Thr Pro Ser Ser Tyr Ser Ser
        1795                1800                1805            
Thr Gly Ser Asn Ala Asn Ile Asn Asn Ala Asn Asn Thr Ala Leu Gly
    1810                1815                1820                
Arg Leu Pro Arg Pro Ala Gly Tyr Pro Ser Thr Val Ser Thr Val Glu
1825                1830                1835                1840
Gly His Gly Pro Pro Leu Ser Pro Ala Ile Arg Val Gln Glu Val Ala
                1845                1850                1855    
Trp Lys Leu Ser Ser Asn Arg Met His Cys Cys Asp Met Leu Asp Gly
            1860                1865                1870        
Gly Thr Phe Pro Pro Ala Leu Gly Pro Arg Arg Ala Pro Pro Cys Leu
        1875                1880                1885            
His Gln Gln Leu Gln Gly Ser Leu Ala Gly Leu Arg Glu Asp Thr Pro
    1890                1895                1900                
Cys Ile Val Pro Gly His Ala Ser Leu Cys Cys Ser Ser Arg Val Gly
1905                1910                1915                1920
Glu Trp Leu Pro Ala Gly Cys Thr Ala Pro Gln His Ala Arg Cys His
                1925                1930                1935    
Ser Arg Glu Ser Gln Ala Ala Met Ala Gly Gln Glu Glu Thr Ser Gln
            1940                1945                1950        
Asp Glu Thr Tyr Glu Val Lys Met Asn His Asp Thr Glu Ala Cys Ser
        1955                1960                1965            
Glu Pro Ser Leu Leu Ser Thr Glu Met Leu Ser Tyr Gln Asp Asp Glu
    1970                1975                1980                
Asn Arg Gln Leu Thr Leu Pro Glu Glu Asp Lys Arg Asp Ile Arg Gln
1985                1990                1995                2000
Ser Pro Lys Arg Gly Phe Leu Arg Ser Ala Ser Leu Gly Arg Arg Ala
                2005                2010                2015    
Ser Phe His Leu Glu Cys Leu Lys Arg Gln Lys Asp Arg Gly Gly Asp
            2020                2025                2030        
Ile Ser Gln Lys Thr Val Leu Pro Leu His Leu Val His His Gln Ala
        2035                2040                2045            
Leu Ala Val Ala Gly Leu Ser Pro Leu Leu Gln Arg Ser His Ser Pro
    2050                2055                2060                
Ala Ser Phe Pro Arg Pro Phe Ala Thr Pro Pro Ala Thr Pro Gly Ser
2065                2070                2075                2080
Arg Gly Trp Pro Pro Gln Pro Val Pro Thr Leu Arg Leu Glu Gly Val
                2085                2090                2095    
Glu Ser Ser Glu Lys Leu Asn Ser Ser Phe Pro Ser Ile His Cys Gly
            2100                2105                2110        
Ser Trp Ala Glu Thr Thr Pro Gly Gly Gly Gly Ser Ser Ala Ala Arg
        2115                2120                2125            
Arg Val Arg Pro Val Ser Leu Met Val Pro Ser Gln Ala Gly Ala Pro
    2130                2135                2140                
Gly Arg Gln Phe His Gly Ser Ala Ser Ser Leu Val Glu Ala Val Leu
2145                2150                2155                2160
Ile Ser Glu Gly Leu Gly Gln Phe Ala Gln Asp Pro Lys Phe Ile Glu
                2165                2170                2175    
Val Thr Thr Gln Glu Leu Ala Asp Ala Cys Asp Met Thr Ile Glu Glu
            2180                2185                2190        
Met Glu Ser Ala Ala Asp Asn Ile Leu Ser Gly Gly Ala Pro Gln Ser
        2195                2200                2205            
Pro Asn Gly Ala Leu Leu Pro Phe Val Asn Cys Arg Asp Ala Gly Gln
    2210                2215                2220                
Asp Arg Ala Gly Gly Glu Glu Asp Ala Gly Cys Val Arg Ala Arg Gly
2225                2230                2235                2240
Ala Pro Ser Glu Glu Glu Leu Gln Asp Ser Arg Val Tyr Val Ser Ser
                2245                2250                2255    
Leu
    


<210> 6499
<211> 2138
<212> PRT
<213> Homo sapiens

<400> 6499
Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln
 1               5                  10                  15      
Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala
            20                  25                  30          
Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala
        35                  40                  45              
Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu
    50                  55                  60                  
Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln
65                  70                  75                  80  
Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr
                85                  90                  95      
Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro
            100                 105                 110         
Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile
        115                 120                 125             
Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr
    130                 135                 140                 
Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu
145                 150                 155                 160 
Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu
                165                 170                 175     
Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg
            180                 185                 190         
Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe
        195                 200                 205             
Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu
    210                 215                 220                 
Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg
225                 230                 235                 240 
Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val
                245                 250                 255     
Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala
            260                 265                 270         
Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu
        275                 280                 285             
Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile
    290                 295                 300                 
Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr
305                 310                 315                 320 
Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp
                325                 330                 335     
Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala
            340                 345                 350         
Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val
        355                 360                 365             
Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr
    370                 375                 380                 
Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val
385                 390                 395                 400 
Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys
                405                 410                 415     
Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu
            420                 425                 430         
Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp
        435                 440                 445             
Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met
    450                 455                 460                 
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala
465                 470                 475                 480 
Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg
                485                 490                 495     
Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe
            500                 505                 510         
Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp
        515                 520                 525             
Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu
    530                 535                 540                 
His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn
545                 550                 555                 560 
Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr
                565                 570                 575     
Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp
            580                 585                 590         
Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr
        595                 600                 605             
Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu
    610                 615                 620                 
Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu
625                 630                 635                 640 
Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu
                645                 650                 655     
Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu
            660                 665                 670         
Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr
        675                 680                 685             
Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr
    690                 695                 700                 
Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly
705                 710                 715                 720 
Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu
                725                 730                 735     
Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala
            740                 745                 750         
Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu
        755                 760                 765             
Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro
    770                 775                 780                 
Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys
785                 790                 795                 800 
Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro
                805                 810                 815     
Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu
            820                 825                 830         
Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu
        835                 840                 845             
Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu
    850                 855                 860                 
Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe
865                 870                 875                 880 
Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile
                885                 890                 895     
Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu
            900                 905                 910         
Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe
        915                 920                 925             
Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe
    930                 935                 940                 
Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His
945                 950                 955                 960 
Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val
                965                 970                 975     
Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn
            980                 985                 990         
Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala
        995                 1000                1005            
Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val Phe Val
    1010                1015                1020                
Ala Ile Arg Thr Ile Gly Asn Ile Val Ile Val Thr Thr Leu Leu Gln
1025                1030                1035                1040
Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys Leu Tyr
                1045                1050                1055    
Thr Cys Ser Asp Ser Ser Lys Gln Thr Glu Ala Glu Cys Lys Gly Asn
            1060                1065                1070        
Tyr Ile Thr Tyr Lys Asp Gly Glu Val Asp His Pro Ile Ile Gln Pro
        1075                1080                1085            
Arg Ser Trp Glu Asn Ser Lys Phe Asp Phe Asp Asn Val Leu Ala Ala
    1090                1095                1100                
Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro Glu Leu
1105                1110                1115                1120
Leu Tyr Arg Ser Ile Asp Ser His Thr Glu Asp Lys Gly Pro Ile Tyr
                1125                1130                1135    
Asn Tyr Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile Ile Ile
            1140                1145                1150        
Ile Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile Val Thr
        1155                1160                1165            
Phe Gln Glu Gln Gly Glu Gln Glu Tyr Lys Asn Cys Glu Leu Asp Lys
    1170                1175                1180                
Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg
1185                1190                1195                1200
Arg Tyr Ile Pro Lys Asn Gln His Gln Tyr Lys Val Trp Tyr Val Val
                1205                1210                1215    
Asn Ser Thr Tyr Phe Glu Tyr Leu Met Phe Val Leu Ile Leu Leu Asn
            1220                1225                1230        
Thr Ile Cys Leu Ala Met Gln His Tyr Gly Gln Ser Cys Leu Phe Lys
        1235                1240                1245            
Ile Ala Met Asn Ile Leu Asn Met Leu Phe Thr Gly Leu Phe Thr Val
    1250                1255                1260                
Glu Met Ile Leu Lys Leu Ile Ala Phe Lys Pro Lys His Tyr Phe Cys
1265                1270                1275                1280
Asp Ala Trp Asn Thr Phe Asp Ala Leu Ile Val Val Gly Ser Ile Val
                1285                1290                1295    
Asp Ile Ala Ile Thr Glu Val Asn Pro Ala Glu His Thr Gln Cys Ser
            1300                1305                1310        
Pro Ser Met Asn Ala Glu Glu Asn Ser Arg Ile Ser Ile Thr Phe Phe
        1315                1320                1325            
Arg Leu Phe Arg Val Met Arg Leu Val Lys Leu Leu Ser Arg Gly Glu
    1330                1335                1340                
Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile Lys Ser Phe Gln Ala Leu
1345                1350                1355                1360
Pro Tyr Val Ala Leu Leu Ile Val Met Leu Phe Phe Ile Tyr Ala Val
                1365                1370                1375    
Ile Gly Met Gln Val Phe Gly Lys Ile Ala Leu Asn Asp Thr Thr Glu
            1380                1385                1390        
Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe Pro Gln Ala Val Leu Leu
        1395                1400                1405            
Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp Gln Asp Ile Met Leu Ala
    1410                1415                1420                
Cys Met Pro Gly Lys Lys Cys Ala Pro Glu Ser Glu Pro Ser Asn Ser
1425                1430                1435                1440
Thr Glu Gly Glu Thr Pro Cys Gly Ser Ser Phe Ala Val Phe Tyr Phe
                1445                1450                1455    
Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile Asn Leu Phe Val
            1460                1465                1470        
Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile
        1475                1480                1485            
Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile Trp Ala Glu Tyr
    1490                1495                1500                
Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp Val Val Thr Leu
1505                1510                1515                1520
Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys Leu Cys Pro His
                1525                1530                1535    
Arg Val Ala Cys Lys Arg Leu Val Ser Met Asn Met Pro Leu Asn Ser
            1540                1545                1550        
Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala Leu Val Arg Thr
        1555                1560                1565            
Ala Leu Arg Ile Lys Thr Glu Gly Asn Leu Glu Gln Ala Asn Glu Glu
    1570                1575                1580                
Leu Arg Ala Ile Ile Lys Lys Ile Trp Lys Arg Thr Ser Met Lys Leu
1585                1590                1595                1600
Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu Val Thr Val Gly
                1605                1610                1615    
Lys Phe Tyr Ala Thr Phe Leu Ile Gln Glu Tyr Phe Arg Lys Phe Lys
            1620                1625                1630        
Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Pro Ser Gln Arg Asn Ala
        1635                1640                1645            
Leu Ser Leu Gln Ala Gly Leu Arg Thr Leu His Asp Ile Gly Pro Glu
    1650                1655                1660                
Ile Arg Arg Ala Ile Ser Gly Asp Leu Thr Ala Glu Glu Glu Leu Asp
1665                1670                1675                1680
Lys Ala Met Lys Glu Ala Val Ser Ala Ala Ser Glu Asp Asp Ile Phe
                1685                1690                1695    
Arg Arg Ala Gly Gly Leu Phe Gly Asn His Val Ser Tyr Tyr Gln Ser
            1700                1705                1710        
Asp Gly Arg Ser Ala Phe Pro Gln Thr Phe Thr Thr Gln Arg Pro Leu
        1715                1720                1725            
His Ile Asn Lys Ala Gly Ser Ser Gln Gly Asp Thr Glu Ser Pro Ser
    1730                1735                1740                
His Glu Lys Leu Val Asp Ser Thr Phe Thr Pro Ser Ser Tyr Ser Ser
1745                1750                1755                1760
Thr Gly Ser Asn Ala Asn Ile Asn Asn Ala Asn Asn Thr Ala Leu Gly
                1765                1770                1775    
Arg Leu Pro Arg Pro Ala Gly Tyr Pro Ser Thr Val Ser Thr Val Glu
            1780                1785                1790        
Gly His Gly Pro Pro Leu Ser Pro Ala Ile Arg Val Gln Glu Val Ala
        1795                1800                1805            
Trp Lys Leu Ser Ser Asn Arg Cys His Ser Arg Glu Ser Gln Ala Ala
    1810                1815                1820                
Met Ala Gly Gln Glu Glu Thr Ser Gln Asp Glu Thr Tyr Glu Val Lys
1825                1830                1835                1840
Met Asn His Asp Thr Glu Ala Cys Ser Glu Pro Ser Leu Leu Ser Thr
                1845                1850                1855    
Glu Met Leu Ser Tyr Gln Asp Asp Glu Asn Arg Gln Leu Thr Leu Pro
            1860                1865                1870        
Glu Glu Asp Lys Arg Asp Ile Arg Gln Ser Pro Lys Arg Gly Phe Leu
        1875                1880                1885            
Arg Ser Ala Ser Leu Gly Arg Arg Ala Ser Phe His Leu Glu Cys Leu
    1890                1895                1900                
Lys Arg Gln Lys Asp Arg Gly Gly Asp Ile Ser Gln Lys Thr Val Leu
1905                1910                1915                1920
Pro Leu His Leu Val His His Gln Ala Leu Ala Val Ala Gly Leu Ser
                1925                1930                1935    
Pro Leu Leu Gln Arg Ser His Ser Pro Ala Ser Phe Pro Arg Pro Phe
            1940                1945                1950        
Ala Thr Pro Pro Ala Thr Pro Gly Ser Arg Gly Trp Pro Pro Gln Pro
        1955                1960                1965            
Val Pro Thr Leu Arg Leu Glu Gly Val Glu Ser Ser Glu Lys Leu Asn
    1970                1975                1980                
Ser Ser Phe Pro Ser Ile His Cys Gly Ser Trp Ala Glu Thr Thr Pro
1985                1990                1995                2000
Gly Gly Gly Gly Ser Ser Ala Ala Arg Arg Val Arg Pro Val Ser Leu
                2005                2010                2015    
Met Val Pro Ser Gln Ala Gly Ala Pro Gly Arg Gln Phe His Gly Ser
            2020                2025                2030        
Ala Ser Ser Leu Val Glu Ala Val Leu Ile Ser Glu Gly Leu Gly Gln
        2035                2040                2045            
Phe Ala Gln Asp Pro Lys Phe Ile Glu Val Thr Thr Gln Glu Leu Ala
    2050                2055                2060                
Asp Ala Cys Asp Met Thr Ile Glu Glu Met Glu Ser Ala Ala Asp Asn
2065                2070                2075                2080
Ile Leu Ser Gly Gly Ala Pro Gln Ser Pro Asn Gly Ala Leu Leu Pro
                2085                2090                2095    
Phe Val Asn Cys Arg Asp Ala Gly Gln Asp Arg Ala Gly Gly Glu Glu
            2100                2105                2110        
Asp Ala Gly Cys Val Arg Ala Arg Gly Arg Pro Ser Glu Glu Glu Leu
        2115                2120                2125            
Gln Asp Ser Arg Val Tyr Val Ser Ser Leu
    2130                2135            


<210> 6500
<211> 2221
<212> PRT
<213> Homo sapiens

<400> 6500
Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln
 1               5                  10                  15      
Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala
            20                  25                  30          
Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala
        35                  40                  45              
Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu
    50                  55                  60                  
Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln
65                  70                  75                  80  
Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr
                85                  90                  95      
Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro
            100                 105                 110         
Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile
        115                 120                 125             
Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr
    130                 135                 140                 
Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu
145                 150                 155                 160 
Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu
                165                 170                 175     
Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg
            180                 185                 190         
Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe
        195                 200                 205             
Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu
    210                 215                 220                 
Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg
225                 230                 235                 240 
Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val
                245                 250                 255     
Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala
            260                 265                 270         
Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu
        275                 280                 285             
Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile
    290                 295                 300                 
Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr
305                 310                 315                 320 
Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp
                325                 330                 335     
Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala
            340                 345                 350         
Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val
        355                 360                 365             
Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr
    370                 375                 380                 
Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val
385                 390                 395                 400 
Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys
                405                 410                 415     
Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu
            420                 425                 430         
Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp
        435                 440                 445             
Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met
    450                 455                 460                 
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala
465                 470                 475                 480 
Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg
                485                 490                 495     
Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe
            500                 505                 510         
Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp
        515                 520                 525             
Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu
    530                 535                 540                 
His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn
545                 550                 555                 560 
Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr
                565                 570                 575     
Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp
            580                 585                 590         
Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr
        595                 600                 605             
Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu
    610                 615                 620                 
Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu
625                 630                 635                 640 
Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu
                645                 650                 655     
Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu
            660                 665                 670         
Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr
        675                 680                 685             
Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr
    690                 695                 700                 
Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly
705                 710                 715                 720 
Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu
                725                 730                 735     
Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala
            740                 745                 750         
Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu
        755                 760                 765             
Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro
    770                 775                 780                 
Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys
785                 790                 795                 800 
Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro
                805                 810                 815     
Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu
            820                 825                 830         
Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu
        835                 840                 845             
Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu
    850                 855                 860                 
Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe
865                 870                 875                 880 
Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile
                885                 890                 895     
Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu
            900                 905                 910         
Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe
        915                 920                 925             
Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe
    930                 935                 940                 
Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe
945                 950                 955                 960 
Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly
                965                 970                 975     
Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu
            980                 985                 990         
Asp Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser
        995                 1000                1005            
Ser Ala Ile Asn Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg
    1010                1015                1020                
Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln
1025                1030                1035                1040
Cys Val Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Val Ile Val Thr
                1045                1050                1055    
Thr Leu Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys
            1060                1065                1070        
Gly Lys Leu Tyr Thr Cys Ser Asp Ser Ser Lys Gln Thr Glu Ala Glu
        1075                1080                1085            
Cys Lys Gly Asn Tyr Ile Thr Tyr Lys Asp Gly Glu Val Asp His Pro
    1090                1095                1100                
Ile Ile Gln Pro Arg Ser Trp Glu Asn Ser Lys Phe Asp Phe Asp Asn
1105                1110                1115                1120
Val Leu Ala Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly
                1125                1130                1135    
Trp Pro Glu Leu Leu Tyr Arg Ser Ile Asp Ser His Thr Glu Asp Lys
            1140                1145                1150        
Gly Pro Ile Tyr Asn Tyr Arg Val Glu Ile Ser Ile Phe Phe Ile Ile
        1155                1160                1165            
Tyr Ile Ile Ile Ile Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe
    1170                1175                1180                
Val Ile Val Thr Phe Gln Glu Gln Gly Glu Gln Glu Tyr Lys Asn Cys
1185                1190                1195                1200
Glu Leu Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala
                1205                1210                1215    
Arg Pro Leu Arg Arg Tyr Ile Pro Lys Asn Gln His Gln Tyr Lys Val
            1220                1225                1230        
Trp Tyr Val Val Asn Ser Thr Tyr Phe Glu Tyr Leu Met Phe Val Leu
        1235                1240                1245            
Ile Leu Leu Asn Thr Ile Cys Leu Ala Met Gln His Tyr Gly Gln Ser
    1250                1255                1260                
Cys Leu Phe Lys Ile Ala Met Asn Ile Leu Asn Met Leu Phe Thr Gly
1265                1270                1275                1280
Leu Phe Thr Val Glu Met Ile Leu Lys Leu Ile Ala Phe Lys Pro Lys
                1285                1290                1295    
Gly Tyr Phe Ser Asp Pro Trp Asn Val Phe Asp Phe Leu Ile Val Ile
            1300                1305                1310        
Gly Ser Ile Ile Asp Val Ile Leu Ser Glu Thr Asn His Tyr Phe Cys
        1315                1320                1325            
Asp Ala Trp Asn Thr Phe Asp Ala Leu Ile Val Val Gly Ser Ile Val
    1330                1335                1340                
Asp Ile Ala Ile Thr Glu Val Asn Pro Ala Glu His Thr Gln Cys Ser
1345                1350                1355                1360
Pro Ser Met Asn Ala Glu Glu Asn Ser Arg Ile Ser Ile Thr Phe Phe
                1365                1370                1375    
Arg Leu Phe Arg Val Met Arg Leu Val Lys Leu Leu Ser Arg Gly Glu
            1380                1385                1390        
Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile Lys Ser Phe Gln Ala Leu
        1395                1400                1405            
Pro Tyr Val Ala Leu Leu Ile Val Met Leu Phe Phe Ile Tyr Ala Val
    1410                1415                1420                
Ile Gly Met Gln Val Phe Gly Lys Ile Ala Leu Asn Asp Thr Thr Glu
1425                1430                1435                1440
Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe Pro Gln Ala Val Leu Leu
                1445                1450                1455    
Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp Gln Asp Ile Met Leu Ala
            1460                1465                1470        
Cys Met Pro Gly Lys Lys Cys Ala Pro Glu Ser Glu Pro Ser Asn Ser
        1475                1480                1485            
Thr Glu Gly Glu Thr Pro Cys Gly Ser Ser Phe Ala Val Phe Tyr Phe
    1490                1495                1500                
Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile Asn Leu Phe Val
1505                1510                1515                1520
Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile
                1525                1530                1535    
Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile Trp Ala Glu Tyr
            1540                1545                1550        
Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp Val Val Thr Leu
        1555                1560                1565            
Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys Leu Cys Pro His
    1570                1575                1580                
Arg Val Ala Cys Lys Arg Leu Val Ser Met Asn Met Pro Leu Asn Ser
1585                1590                1595                1600
Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala Leu Val Arg Thr
                1605                1610                1615    
Ala Leu Arg Ile Lys Thr Glu Gly Asn Leu Glu Gln Ala Asn Glu Glu
            1620                1625                1630        
Leu Arg Ala Ile Ile Lys Lys Ile Trp Lys Arg Thr Ser Met Lys Leu
        1635                1640                1645            
Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu Val Thr Val Gly
    1650                1655                1660                
Lys Phe Tyr Ala Thr Phe Leu Ile Gln Glu Tyr Phe Arg Lys Phe Lys
1665                1670                1675                1680
Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Pro Ser Gln Arg Asn Ala
                1685                1690                1695    
Leu Ser Leu Gln Ala Gly Leu Arg Thr Leu His Asp Ile Gly Pro Glu
            1700                1705                1710        
Ile Arg Arg Ala Ile Ser Gly Asp Leu Thr Ala Glu Glu Glu Leu Asp
        1715                1720                1725            
Lys Ala Met Lys Glu Ala Val Ser Ala Ala Ser Glu Asp Asp Ile Phe
    1730                1735                1740                
Arg Arg Ala Gly Gly Leu Phe Gly Asn His Val Ser Tyr Tyr Gln Ser
1745                1750                1755                1760
Asp Gly Arg Ser Ala Phe Pro Gln Thr Phe Thr Thr Gln Arg Pro Leu
                1765                1770                1775    
His Ile Asn Lys Ala Gly Ser Ser Gln Gly Asp Thr Glu Ser Pro Ser
            1780                1785                1790        
His Glu Lys Leu Val Asp Ser Thr Phe Thr Pro Ser Ser Tyr Ser Ser
        1795                1800                1805            
Thr Gly Ser Asn Ala Asn Ile Asn Asn Ala Asn Asn Thr Ala Leu Gly
    1810                1815                1820                
Arg Leu Pro Arg Pro Ala Gly Tyr Pro Ser Thr Val Ser Thr Val Glu
1825                1830                1835                1840
Gly His Gly Pro Pro Leu Ser Pro Ala Ile Arg Val Gln Glu Val Ala
                1845                1850                1855    
Trp Lys Leu Ser Ser Asn Arg Glu Arg His Val Pro Val Cys Glu Asp
            1860                1865                1870        
Leu Glu Leu Arg Arg Asp Ser Gly Ser Ala Gly Thr Gln Ala His Cys
        1875                1880                1885            
Leu Leu Leu Arg Arg Ala Asn Pro Ser Arg Cys His Ser Arg Glu Ser
    1890                1895                1900                
Gln Ala Ala Met Ala Gly Gln Glu Glu Thr Ser Gln Asp Glu Thr Tyr
1905                1910                1915                1920
Glu Val Lys Met Asn His Asp Thr Glu Ala Cys Ser Glu Pro Ser Leu
                1925                1930                1935    
Leu Ser Thr Glu Met Leu Ser Tyr Gln Asp Asp Glu Asn Arg Gln Leu
            1940                1945                1950        
Thr Leu Pro Glu Glu Asp Lys Arg Asp Ile Arg Gln Ser Pro Lys Arg
        1955                1960                1965            
Gly Phe Leu Arg Ser Ala Ser Leu Gly Arg Arg Ala Ser Phe His Leu
    1970                1975                1980                
Glu Cys Leu Lys Arg Gln Lys Asp Arg Gly Gly Asp Ile Ser Gln Lys
1985                1990                1995                2000
Thr Val Leu Pro Leu His Leu Val His His Gln Ala Leu Ala Val Ala
                2005                2010                2015    
Gly Leu Ser Pro Leu Leu Gln Arg Ser His Ser Pro Ala Ser Phe Pro
            2020                2025                2030        
Arg Pro Phe Ala Thr Pro Pro Ala Thr Pro Gly Ser Arg Gly Trp Pro
        2035                2040                2045            
Pro Gln Pro Val Pro Thr Leu Arg Leu Glu Gly Val Glu Ser Ser Glu
    2050                2055                2060                
Lys Leu Asn Ser Ser Phe Pro Ser Ile His Cys Gly Ser Trp Ala Glu
2065                2070                2075                2080
Thr Thr Pro Gly Gly Gly Gly Ser Ser Ala Ala Arg Arg Val Arg Pro
                2085                2090                2095    
Val Ser Leu Met Val Pro Ser Gln Ala Gly Ala Pro Gly Arg Gln Phe
            2100                2105                2110        
His Gly Ser Ala Ser Ser Leu Val Glu Ala Val Leu Ile Ser Glu Gly
        2115                2120                2125            
Leu Gly Gln Phe Ala Gln Asp Pro Lys Phe Ile Glu Val Thr Thr Gln
    2130                2135                2140                
Glu Leu Ala Asp Ala Cys Asp Met Thr Ile Glu Glu Met Glu Ser Ala
2145                2150                2155                2160
Ala Asp Asn Ile Leu Ser Gly Gly Ala Pro Gln Ser Pro Asn Gly Ala
                2165                2170                2175    
Leu Leu Pro Phe Val Asn Cys Arg Asp Ala Gly Gln Asp Arg Ala Gly
            2180                2185                2190        
Gly Glu Glu Asp Ala Gly Cys Val Arg Ala Arg Gly Ala Pro Ser Glu
        2195                2200                2205            
Glu Glu Leu Gln Asp Ser Arg Val Tyr Val Ser Ser Leu
    2210                2215                2220    


<210> 6501
<211> 1243
<212> PRT
<213> Homo sapiens

<400> 6501
Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn
 1               5                  10                  15      
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg
            20                  25                  30          
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu
        35                  40                  45              
Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro
    50                  55                  60                  
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln
65                  70                  75                  80  
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu
                85                  90                  95      
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu
            100                 105                 110         
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly
        115                 120                 125             
Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu
    130                 135                 140                 
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser
145                 150                 155                 160 
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu
                165                 170                 175     
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe
            180                 185                 190         
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile
        195                 200                 205             
Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala
    210                 215                 220                 
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser
225                 230                 235                 240 
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro
                245                 250                 255     
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu
            260                 265                 270         
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu
        275                 280                 285             
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val
    290                 295                 300                 
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala
305                 310                 315                 320 
Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met
                325                 330                 335     
Gln Asp Gly Asn Val Asp Ala Ser Gln Ser Lys Ala Lys Gln Gln Asp
            340                 345                 350         
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly
        355                 360                 365             
Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu Lys Ser
    370                 375                 380                 
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala
385                 390                 395                 400 
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe
                405                 410                 415     
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro Glu Cys
            420                 425                 430         
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val
        435                 440                 445             
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr
    450                 455                 460                 
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu
465                 470                 475                 480 
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile
                485                 490                 495     
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val
            500                 505                 510         
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser
        515                 520                 525             
Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile Ala Ile
    530                 535                 540                 
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala
545                 550                 555                 560 
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe
                565                 570                 575     
Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro
            580                 585                 590         
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser
        595                 600                 605             
Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met Tyr Ser
    610                 615                 620                 
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Asn
625                 630                 635                 640 
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met
                645                 650                 655     
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile
            660                 665                 670         
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp
        675                 680                 685             
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly
    690                 695                 700                 
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys
705                 710                 715                 720 
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn
                725                 730                 735     
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu
            740                 745                 750         
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn
        755                 760                 765             
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys
    770                 775                 780                 
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val
785                 790                 795                 800 
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala
                805                 810                 815     
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp
            820                 825                 830         
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala
        835                 840                 845             
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala
    850                 855                 860                 
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln
865                 870                 875                 880 
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly
                885                 890                 895     
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp
            900                 905                 910         
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu
        915                 920                 925             
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys
    930                 935                 940                 
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val
945                 950                 955                 960 
Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met
                965                 970                 975     
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser
            980                 985                 990         
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe
        995                 1000                1005            
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp
    1010                1015                1020                
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe
1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys
                1045                1050                1055    
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu
            1060                1065                1070        
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg
        1075                1080                1085            
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile
    1090                1095                1100                
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu
1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg
                1125                1130                1135    
Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser Leu Tyr
            1140                1145                1150        
Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn Phe Met
        1155                1160                1165            
Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile Pro Leu
    1170                1175                1180                
Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln Asn Ser
1185                1190                1195                1200
Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp Ser Gly
                1205                1210                1215    
Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser Ser Pro
            1220                1225                1230        
Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu
        1235                1240            


<210> 6502
<211> 1199
<212> PRT
<213> Homo sapiens

<400> 6502
Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn
 1               5                  10                  15      
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg
            20                  25                  30          
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu
        35                  40                  45              
Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro
    50                  55                  60                  
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln
65                  70                  75                  80  
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu
                85                  90                  95      
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu
            100                 105                 110         
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly
        115                 120                 125             
Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu
    130                 135                 140                 
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser
145                 150                 155                 160 
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu
                165                 170                 175     
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe
            180                 185                 190         
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile
        195                 200                 205             
Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala
    210                 215                 220                 
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser
225                 230                 235                 240 
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro
                245                 250                 255     
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu
            260                 265                 270         
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu
        275                 280                 285             
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val
    290                 295                 300                 
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala
305                 310                 315                 320 
Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met
                325                 330                 335     
Gln Asp Gly Asn Val Asp Ala Ser Gln Ser Lys Ala Lys Gln Gln Asp
            340                 345                 350         
Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly
        355                 360                 365             
Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu Lys Ser
    370                 375                 380                 
Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala
385                 390                 395                 400 
Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe
                405                 410                 415     
Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro Glu Cys
            420                 425                 430         
Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val
        435                 440                 445             
Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr
    450                 455                 460                 
Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu
465                 470                 475                 480 
Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile
                485                 490                 495     
Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val
            500                 505                 510         
Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser
        515                 520                 525             
Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile Ala Ile
    530                 535                 540                 
Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala
545                 550                 555                 560 
Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe
                565                 570                 575     
Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro
            580                 585                 590         
Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser
        595                 600                 605             
Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met Tyr Ser
    610                 615                 620                 
Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Asn
625                 630                 635                 640 
Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met
                645                 650                 655     
Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile
            660                 665                 670         
Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp
        675                 680                 685             
Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly
    690                 695                 700                 
Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys
705                 710                 715                 720 
Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn
                725                 730                 735     
Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu
            740                 745                 750         
Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn
        755                 760                 765             
Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys
    770                 775                 780                 
Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val
785                 790                 795                 800 
Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala
                805                 810                 815     
Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp
            820                 825                 830         
Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala
        835                 840                 845             
Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala
    850                 855                 860                 
Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln
865                 870                 875                 880 
Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly
                885                 890                 895     
Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp
            900                 905                 910         
Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu
        915                 920                 925             
Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys
    930                 935                 940                 
Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val
945                 950                 955                 960 
Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met
                965                 970                 975     
Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser
            980                 985                 990         
Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln Leu Phe
        995                 1000                1005            
Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val Phe Asp
    1010                1015                1020                
Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly Thr Phe
1025                1030                1035                1040
Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe Ser Cys
                1045                1050                1055    
Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile Gly Leu
            1060                1065                1070        
Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr Ser Arg
        1075                1080                1085            
Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu Glu Ile
    1090                1095                1100                
Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His Ala Glu
1105                1110                1115                1120
Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg
                1125                1130                1135    
Ile Gln Thr Gln Ile Glu Val Val Asn Thr Phe Lys Ser Gly Ala Ser
            1140                1145                1150        
Phe Gln Gly Ala Leu Arg Arg Gln Ser Ser Val Thr Ser Gln Ser Gln
        1155                1160                1165            
Asp Val Ala Asn Leu Ser Ser Pro Ser Arg Val Ser Leu Ser Asn Ala
    1170                1175                1180                
Leu Ser Ser Pro Thr Ser Leu Pro Pro Ala Ala Ala Gly Gln Gly
1185                1190                1195                


<210> 6503
<211> 220
<212> PRT
<213> Homo sapiens

<400> 6503
Met Thr Ser Ser Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr Ile
 1               5                  10                  15      
Leu Asp Thr Thr Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val Gln
            20                  25                  30          
Asn His Thr Arg Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly Arg
        35                  40                  45              
Val Asp Leu Lys Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys Val
    50                  55                  60                  
Ser Ser Ile Ser Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg Leu
65                  70                  75                  80  
Gly Arg Asp Gln Ser Val Ser Val Ser Val Val Leu Asn Val Thr Phe
                85                  90                  95      
Glu Glu Gly Ser Asn Val Lys Leu Val Cys Asn Val Lys Ala Asn Pro
            100                 105                 110         
Gln Ala Gln Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp Leu Glu
        115                 120                 125             
Lys Ser Arg His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln Leu Ser
    130                 135                 140                 
Ile Thr Lys Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys Ile Ala
145                 150                 155                 160 
Lys Ser Ser Leu Lys Thr Glu Ser Leu Asp Phe His Leu Ile Val Lys
                165                 170                 175     
Asp Lys Thr Val Gly Val Pro Ile Glu Pro Ile Ile Ala Ala Cys Val
            180                 185                 190         
Val Ile Phe Leu Thr Leu Cys Phe Gly Leu Ile Ala Arg Arg Lys Lys
        195                 200                 205             
Ile Met Lys Val Ser Lys Tyr Ser Glu Leu Phe Lys
    210                 215                 220 


<210> 6504
<211> 1966
<212> PRT
<213> Homo sapiens

<400> 6504
Met Glu Phe Pro Ile Gly Ser Leu Glu Thr Asn Asn Phe Arg Arg Phe
 1               5                  10                  15      
Thr Pro Glu Ser Leu Val Glu Ile Glu Lys Gln Ile Ala Ala Lys Gln
            20                  25                  30          
Gly Thr Lys Lys Ala Arg Glu Lys His Arg Glu Gln Lys Asp Gln Glu
        35                  40                  45              
Glu Lys Pro Arg Pro Gln Leu Asp Leu Lys Ala Cys Asn Gln Leu Pro
    50                  55                  60                  
Lys Phe Tyr Gly Glu Leu Pro Ala Glu Leu Ile Gly Glu Pro Leu Glu
65                  70                  75                  80  
Asp Leu Asp Pro Phe Tyr Ser Thr His Arg Thr Phe Met Val Leu Asn
                85                  90                  95      
Lys Gly Arg Thr Ile Ser Arg Phe Ser Ala Thr Arg Ala Leu Trp Leu
            100                 105                 110         
Phe Ser Pro Phe Asn Leu Ile Arg Arg Thr Ala Ile Lys Val Ser Val
        115                 120                 125             
His Ser Tyr Pro Leu His Asp Cys Leu Phe His Val Trp Phe Ser Leu
    130                 135                 140                 
Phe Ile Thr Val Thr Ile Leu Val Asn Cys Val Cys Met Thr Arg Thr
145                 150                 155                 160 
Asp Leu Pro Glu Lys Ile Glu Tyr Val Phe Thr Val Ile Tyr Thr Phe
                165                 170                 175     
Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Asn Glu Phe
            180                 185                 190         
Thr Tyr Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Thr
        195                 200                 205             
Leu Ala Tyr Val Gly Thr Ala Ile Asp Leu Arg Gly Ile Ser Gly Leu
    210                 215                 220                 
Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr Val Ser Val Ile Pro
225                 230                 235                 240 
Gly Leu Lys Val Ile Val Gly Ala Leu Ile His Ser Val Lys Lys Leu
                245                 250                 255     
Ala Asp Val Thr Ile Leu Thr Ile Phe Cys Leu Ser Val Phe Ala Leu
            260                 265                 270         
Val Gly Leu Gln Leu Phe Lys Gly Asn Leu Lys Asn Lys Cys Val Lys
        275                 280                 285             
Asn Asp Met Ala Val Asn Glu Thr Thr Asn Tyr Ser Ser His Arg Lys
    290                 295                 300                 
Pro Asp Ile Tyr Ile Asn Lys Arg Gly Thr Ser Asp Pro Leu Leu Cys
305                 310                 315                 320 
Gly Asn Gly Ser Asp Ser Gly His Cys Pro Asp Gly Tyr Ile Cys Leu
                325                 330                 335     
Lys Thr Ser Asp Asn Pro Asp Phe Asn Tyr Thr Ser Phe Asp Ser Phe
            340                 345                 350         
Ala Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Ser Trp
        355                 360                 365             
Glu Arg Leu Tyr Gln Gln Thr Leu Arg Thr Ser Gly Lys Ile Tyr Met
    370                 375                 380                 
Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val Asn
385                 390                 395                 400 
Leu Ile Leu Ala Val Val Thr Met Ala Tyr Glu Glu Gln Asn Gln Ala
                405                 410                 415     
Thr Thr Asp Glu Ile Glu Ala Lys Glu Lys Lys Phe Gln Glu Ala Leu
            420                 425                 430         
Glu Met Leu Arg Lys Glu Gln Glu Val Leu Ala Ala Leu Gly Ile Asp
        435                 440                 445             
Thr Thr Ser Leu His Ser His Asn Gly Ser Pro Leu Thr Ser Lys Asn
    450                 455                 460                 
Ala Ser Glu Arg Arg His Arg Ile Lys Pro Arg Val Ser Glu Gly Ser
465                 470                 475                 480 
Thr Glu Asp Asn Lys Ser Pro Arg Ser Asp Pro Tyr Asn Gln Arg Arg
                485                 490                 495     
Met Ser Phe Leu Gly Leu Ala Ser Gly Lys Arg Arg Ala Ser His Gly
            500                 505                 510         
Ser Val Phe His Phe Arg Ser Pro Gly Arg Asp Ile Ser Leu Pro Glu
        515                 520                 525             
Gly Val Thr Asp Asp Gly Val Phe Pro Gly Asp His Glu Ser His Arg
    530                 535                 540                 
Gly Ser Leu Leu Leu Gly Gly Gly Ala Gly Gln Gln Gly Pro Leu Pro
545                 550                 555                 560 
Arg Ser Pro Leu Pro Gln Pro Ser Asn Pro Asp Ser Arg His Gly Glu
                565                 570                 575     
Asp Glu His Gln Pro Pro Pro Thr Ser Glu Leu Ala Pro Gly Ala Val
            580                 585                 590         
Asp Val Ser Ala Phe Asp Ala Gly Gln Lys Lys Thr Phe Leu Ser Ala
        595                 600                 605             
Glu Tyr Leu Asp Glu Pro Phe Arg Ala Gln Arg Ala Met Ser Val Val
    610                 615                 620                 
Ser Ile Ile Thr Ser Val Leu Glu Glu Leu Glu Glu Ser Glu Gln Lys
625                 630                 635                 640 
Cys Pro Pro Cys Leu Thr Ser Leu Ser Gln Lys Tyr Leu Ile Trp Asp
                645                 650                 655     
Cys Cys Pro Met Trp Val Lys Leu Lys Thr Ile Leu Phe Gly Leu Val
            660                 665                 670         
Thr Asp Pro Phe Ala Glu Leu Thr Ile Thr Leu Cys Ile Val Val Asn
        675                 680                 685             
Thr Ile Phe Met Ala Met Glu His His Gly Met Ser Pro Thr Phe Glu
    690                 695                 700                 
Ala Met Leu Gln Ile Gly Asn Ile Val Phe Thr Ile Phe Phe Thr Ala
705                 710                 715                 720 
Glu Met Val Phe Lys Ile Ile Ala Phe Asp Pro Tyr Tyr Tyr Phe Gln
                725                 730                 735     
Lys Lys Trp Asn Ile Phe Asp Cys Ile Ile Val Thr Val Ser Leu Leu
            740                 745                 750         
Glu Leu Gly Val Ala Lys Lys Gly Ser Leu Ser Val Leu Arg Ser Phe
        755                 760                 765             
Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn
    770                 775                 780                 
Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu
785                 790                 795                 800 
Thr Ile Ile Leu Ala Ile Ile Val Phe Val Phe Ala Leu Val Gly Lys
                805                 810                 815     
Gln Leu Leu Gly Glu Asn Tyr Arg Asn Asn Arg Lys Asn Ile Ser Ala
            820                 825                 830         
Pro His Glu Asp Trp Pro Arg Trp His Met His Asp Phe Phe His Ser
        835                 840                 845             
Phe Leu Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Asn Met
    850                 855                 860                 
Trp Ala Cys Met Glu Val Gly Gln Lys Ser Ile Cys Leu Ile Leu Phe
865                 870                 875                 880 
Leu Thr Val Met Val Leu Gly Asn Leu Val Val Leu Asn Leu Phe Ile
                885                 890                 895     
Ala Leu Leu Leu Asn Ser Phe Ser Ala Asp Asn Leu Thr Ala Pro Glu
            900                 905                 910         
Asp Asp Gly Glu Val Asn Asn Leu Gln Val Ala Leu Ala Arg Ile Gln
        915                 920                 925             
Val Phe Gly His Arg Thr Lys Gln Ala Leu Cys Ser Phe Phe Ser Arg
    930                 935                 940                 
Ser Cys Pro Phe Pro Gln Pro Lys Ala Glu Pro Glu Leu Val Val Lys
945                 950                 955                 960 
Leu Pro Leu Ser Ser Ser Lys Ala Glu Asn His Ile Ala Ala Asn Thr
                965                 970                 975     
Ala Arg Gly Ser Ser Gly Gly Leu Gln Ala Pro Arg Gly Pro Arg Asp
            980                 985                 990         
Glu His Ser Asp Phe Ile Ala Asn Pro Thr Val Trp Val Ser Val Pro
        995                 1000                1005            
Ile Ala Glu Gly Glu Ser Asp Leu Asp Asp Leu Glu Asp Asp Gly Gly
    1010                1015                1020                
Glu Asp Ala Gln Ser Phe Gln Gln Glu Val Ile Pro Lys Gly Gln Gln
1025                1030                1035                1040
Glu Gln Leu Gln Gln Val Glu Arg Cys Gly Asp His Leu Thr Pro Arg
                1045                1050                1055    
Ser Pro Gly Thr Gly Thr Ser Ser Glu Asp Leu Ala Pro Ser Leu Gly
            1060                1065                1070        
Glu Thr Trp Lys Asp Glu Ser Val Pro Gln Val Pro Ala Glu Gly Val
        1075                1080                1085            
Asp Asp Thr Ser Ser Ser Glu Gly Ser Thr Val Asp Cys Leu Asp Pro
    1090                1095                1100                
Glu Glu Ile Leu Arg Lys Ile Pro Glu Leu Ala Asp Asp Leu Glu Glu
1105                1110                1115                1120
Pro Asp Asp Cys Phe Thr Glu Gly Cys Ile Arg His Cys Pro Cys Cys
                1125                1130                1135    
Lys Leu Asp Thr Thr Lys Ser Pro Trp Asp Val Gly Trp Gln Val Arg
            1140                1145                1150        
Lys Thr Cys Tyr Arg Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile
        1155                1160                1165            
Ile Phe Met Ile Leu Leu Ser Ser Gly Ser Leu Ala Phe Glu Asp Tyr
    1170                1175                1180                
Tyr Leu Asp Gln Lys Pro Thr Val Lys Ala Leu Leu Glu Tyr Thr Asp
1185                1190                1195                1200
Arg Val Phe Thr Phe Ile Phe Val Phe Glu Met Leu Leu Lys Trp Val
                1205                1210                1215    
Ala Tyr Gly Phe Lys Lys Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp
            1220                1225                1230        
Phe Leu Ile Val Asn Ile Ser Leu Ile Ser Leu Thr Ala Lys Ile Leu
        1235                1240                1245            
Glu Tyr Ser Glu Val Ala Pro Ile Lys Ala Leu Arg Thr Leu Arg Ala
    1250                1255                1260                
Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val
1265                1270                1275                1280
Val Asp Ala Leu Val Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu
                1285                1290                1295    
Val Cys Leu Ile Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu
            1300                1305                1310        
Phe Ala Gly Lys Phe Trp Arg Cys Ile Asn Tyr Thr Asp Gly Glu Phe
        1315                1320                1325            
Ser Leu Val Pro Leu Ser Ile Val Asn Asn Lys Ser Asp Cys Lys Ile
    1330                1335                1340                
Gln Asn Ser Thr Gly Ser Phe Phe Trp Val Asn Val Lys Val Asn Phe
1345                1350                1355                1360
Asp Asn Val Ala Met Gly Tyr Leu Ala Leu Leu Gln Val Ala Thr Phe
                1365                1370                1375    
Lys Gly Trp Met Asp Ile Met Tyr Ala Ala Val Asp Ser Arg Glu Val
            1380                1385                1390        
Asn Met Gln Pro Lys Trp Glu Asp Asn Val Tyr Met Tyr Leu Tyr Phe
        1395                1400                1405            
Val Ile Phe Ile Ile Phe Gly Gly Phe Phe Thr Leu Asn Leu Phe Val
    1410                1415                1420                
Gly Val Ile Ile Asp Asn Phe Asn Gln Gln Lys Lys Lys Ile Arg Gly
1425                1430                1435                1440
Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met
                1445                1450                1455    
Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Leu
            1460                1465                1470        
Asn Lys Phe Gln Gly Phe Val Phe Asp Ile Val Thr Arg Gln Ala Phe
        1475                1480                1485            
Asp Ile Thr Ile Met Val Leu Ile Cys Leu Asn Met Ile Thr Met Met
    1490                1495                1500                
Val Glu Thr Asp Asp Gln Ser Glu Glu Lys Thr Lys Ile Leu Gly Lys
1505                1510                1515                1520
Ile Asn Gln Phe Phe Val Ala Val Phe Thr Gly Glu Cys Val Met Lys
                1525                1530                1535    
Met Phe Ala Leu Arg Gln Tyr Tyr Phe Thr Asn Gly Trp Asn Val Phe
            1540                1545                1550        
Asp Phe Ile Val Val Val Leu Ser Ile Ala Ser Leu Ile Phe Ser Ala
        1555                1560                1565            
Ile Leu Lys Ser Leu Gln Ser Tyr Phe Ser Pro Thr Leu Phe Arg Val
    1570                1575                1580                
Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg Leu Ile Arg Ala Ala
1585                1590                1595                1600
Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met Met Ser Leu Pro Ala
                1605                1610                1615    
Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val Met Phe Ile Tyr Ser
            1620                1625                1630        
Ile Phe Gly Met Ser Ser Phe Pro His Val Arg Trp Glu Ala Gly Ile
        1635                1640                1645            
Asp Asp Met Phe Asn Phe Gln Thr Phe Ala Asn Ser Met Leu Cys Leu
    1650                1655                1660                
Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly Leu Leu Ser Pro Ile
1665                1670                1675                1680
Leu Asn Thr Gly Pro Pro Tyr Cys Asp Pro Asn Leu Pro Asn Ser Asn
                1685                1690                1695    
Gly Thr Arg Gly Asp Cys Gly Ser Pro Ala Val Gly Ile Ile Phe Phe
            1700                1705                1710        
Thr Thr Tyr Ile Ile Ile Ser Phe Leu Ile Met Val Asn Met Tyr Ile
        1715                1720                1725            
Ala Val Ile Leu Glu Asn Phe Asn Val Ala Thr Glu Glu Ser Thr Glu
    1730                1735                1740                
Pro Leu Ser Glu Asp Asp Phe Asp Met Phe Tyr Glu Thr Trp Glu Lys
1745                1750                1755                1760
Phe Asp Pro Glu Ala Thr Gln Phe Ile Thr Phe Ser Ala Leu Ser Asp
                1765                1770                1775    
Phe Ala Asp Thr Leu Ser Gly Pro Leu Arg Ile Pro Lys Pro Asn Arg
            1780                1785                1790        
Asn Ile Leu Ile Gln Met Asp Leu Pro Leu Val Pro Gly Asp Lys Ile
        1795                1800                1805            
His Cys Leu Asp Ile Leu Phe Ala Phe Thr Lys Asn Val Leu Gly Glu
    1810                1815                1820                
Ser Gly Glu Leu Asp Ser Leu Lys Ala Asn Met Glu Glu Lys Phe Met
1825                1830                1835                1840
Ala Thr Asn Leu Ser Lys Ser Ser Tyr Glu Pro Ile Ala Thr Thr Leu
                1845                1850                1855    
Arg Trp Lys Gln Glu Asp Ile Ser Ala Thr Val Ile Gln Lys Ala Tyr
            1860                1865                1870        
Arg Ser Tyr Val Leu His Arg Ser Met Ala Leu Ser Asn Thr Pro Cys
        1875                1880                1885            
Val Pro Arg Ala Glu Glu Glu Ala Ala Ser Leu Pro Asp Glu Gly Phe
    1890                1895                1900                
Val Ala Phe Thr Ala Asn Glu Asn Cys Val Leu Pro Asp Lys Ser Glu
1905                1910                1915                1920
Thr Ala Ser Ala Thr Ser Phe Pro Pro Ser Tyr Glu Ser Val Thr Arg
                1925                1930                1935    
Gly Leu Ser Asp Arg Val Asn Met Arg Thr Ser Ser Ser Ile Gln Asn
            1940                1945                1950        
Glu Asp Glu Ala Thr Ser Met Glu Leu Ile Ala Pro Gly Pro
        1955                1960                1965    


<210> 6505
<211> 1286
<212> PRT
<213> Homo sapiens

<400> 6505
Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser
 1               5                  10                  15      
Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys
            20                  25                  30          
Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr
        35                  40                  45              
Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala
    50                  55                  60                  
Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu
65                  70                  75                  80  
Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val
                85                  90                  95      
Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu
            100                 105                 110         
Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu
        115                 120                 125             
Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg
    130                 135                 140                 
Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln
145                 150                 155                 160 
Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg
                165                 170                 175     
Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val
            180                 185                 190         
Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val
        195                 200                 205             
Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser
    210                 215                 220                 
Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala
225                 230                 235                 240 
Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala
                245                 250                 255     
Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln
            260                 265                 270         
Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu
        275                 280                 285             
Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala
    290                 295                 300                 
Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser
305                 310                 315                 320 
Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val
                325                 330                 335     
Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro
            340                 345                 350         
Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe
        355                 360                 365             
Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly
    370                 375                 380                 
His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His
385                 390                 395                 400 
Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn
                405                 410                 415     
Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly
            420                 425                 430         
Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro
        435                 440                 445             
Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn
    450                 455                 460                 
Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val
465                 470                 475                 480 
Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn
                485                 490                 495     
Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr
            500                 505                 510         
Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu
        515                 520                 525             
Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala
    530                 535                 540                 
Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr
545                 550                 555                 560 
Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp
                565                 570                 575     
Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser
            580                 585                 590         
Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile
        595                 600                 605             
Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr
    610                 615                 620                 
Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu
625                 630                 635                 640 
Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn
                645                 650                 655     
Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys
            660                 665                 670         
Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu
        675                 680                 685             
Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn
    690                 695                 700                 
Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala
705                 710                 715                 720 
Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile
                725                 730                 735     
Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn
            740                 745                 750         
Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr
        755                 760                 765             
Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr
    770                 775                 780                 
Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met
785                 790                 795                 800 
Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg
                805                 810                 815     
Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu
            820                 825                 830         
Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile
        835                 840                 845             
Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val
    850                 855                 860                 
Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly
865                 870                 875                 880 
Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala
                885                 890                 895     
Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu
            900                 905                 910         
Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg
        915                 920                 925             
Asn Ser Val Gln Lys Ala His Ile Tyr Gly Ile Thr Phe Ser Ile Ser
    930                 935                 940                 
Gln Ala Phe Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly Ala
945                 950                 955                 960 
Tyr Leu Ile Val Asn Gly His Met Arg Phe Arg Asp Val Ile Leu Val
                965                 970                 975     
Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser Ser
            980                 985                 990         
Phe Ala Pro Asp Tyr Ala Lys Ala Lys Leu Ser Ala Ala His Leu Phe
        995                 1000                1005            
Met Leu Phe Glu Arg Gln Pro Leu Ile Asp Ser Tyr Ser Glu Glu Gly
    1010                1015                1020                
Leu Lys Pro Asp Lys Phe Glu Gly Asn Ile Thr Phe Asn Glu Val Val
1025                1030                1035                1040
Phe Asn Tyr Pro Thr Arg Ala Asn Val Pro Val Leu Gln Gly Leu Ser
                1045                1050                1055    
Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly Ser Ser Gly
            1060                1065                1070        
Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe Tyr Asp Pro
        1075                1080                1085            
Leu Ala Gly Thr Val Phe Val Asp Phe Gly Phe Gln Leu Leu Asp Gly
    1090                1095                1100                
Gln Glu Ala Lys Lys Leu Asn Val Gln Trp Leu Arg Ala Gln Leu Gly
1105                1110                1115                1120
Ile Val Ser Gln Glu Pro Ile Leu Phe Asp Cys Ser Ile Ala Glu Asn
                1125                1130                1135    
Ile Ala Tyr Gly Asp Asn Ser Arg Val Val Ser Gln Asp Glu Ile Val
            1140                1145                1150        
Ser Ala Ala Lys Ala Ala Asn Ile His Pro Phe Ile Glu Thr Leu Pro
        1155                1160                1165            
His Lys Tyr Glu Thr Arg Val Gly Asp Lys Gly Thr Gln Leu Ser Gly
    1170                1175                1180                
Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Ile Arg Gln Pro
1185                1190                1195                1200
Gln Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala Leu Asp Thr Glu Ser
                1205                1210                1215    
Glu Lys Val Val Gln Glu Ala Leu Asp Lys Ala Arg Glu Gly Arg Thr
            1220                1225                1230        
Cys Ile Val Ile Ala His Arg Leu Ser Thr Ile Gln Asn Ala Asp Leu
        1235                1240                1245            
Ile Val Val Phe Gln Asn Gly Arg Val Lys Glu His Gly Thr His Gln
    1250                1255                1260                
Gln Leu Leu Ala Gln Lys Gly Ile Tyr Phe Ser Met Val Ser Val Gln
1265                1270                1275                1280
Ala Gly Thr Gln Asn Leu
                1285    


<210> 6506
<211> 1232
<212> PRT
<213> Homo sapiens

<400> 6506
Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser
 1               5                  10                  15      
Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys
            20                  25                  30          
Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr
        35                  40                  45              
Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala
    50                  55                  60                  
Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu
65                  70                  75                  80  
Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val
                85                  90                  95      
Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu
            100                 105                 110         
Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu
        115                 120                 125             
Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg
    130                 135                 140                 
Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln
145                 150                 155                 160 
Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg
                165                 170                 175     
Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val
            180                 185                 190         
Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val
        195                 200                 205             
Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser
    210                 215                 220                 
Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala
225                 230                 235                 240 
Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala
                245                 250                 255     
Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln
            260                 265                 270         
Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu
        275                 280                 285             
Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala
    290                 295                 300                 
Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser
305                 310                 315                 320 
Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val
                325                 330                 335     
Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro
            340                 345                 350         
Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe
        355                 360                 365             
Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly
    370                 375                 380                 
His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His
385                 390                 395                 400 
Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn
                405                 410                 415     
Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly
            420                 425                 430         
Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro
        435                 440                 445             
Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn
    450                 455                 460                 
Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val
465                 470                 475                 480 
Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn
                485                 490                 495     
Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr
            500                 505                 510         
Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu
        515                 520                 525             
Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala
    530                 535                 540                 
Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr
545                 550                 555                 560 
Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp
                565                 570                 575     
Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser
            580                 585                 590         
Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile
        595                 600                 605             
Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr
    610                 615                 620                 
Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu
625                 630                 635                 640 
Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn
                645                 650                 655     
Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys
            660                 665                 670         
Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu
        675                 680                 685             
Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn
    690                 695                 700                 
Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala
705                 710                 715                 720 
Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile
                725                 730                 735     
Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn
            740                 745                 750         
Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr
        755                 760                 765             
Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr
    770                 775                 780                 
Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met
785                 790                 795                 800 
Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg
                805                 810                 815     
Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu
            820                 825                 830         
Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile
        835                 840                 845             
Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val
    850                 855                 860                 
Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly
865                 870                 875                 880 
Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala
                885                 890                 895     
Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu
            900                 905                 910         
Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg
        915                 920                 925             
Val Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser
    930                 935                 940                 
Ser Phe Ala Pro Asp Tyr Ala Lys Ala Lys Leu Ser Ala Ala His Leu
945                 950                 955                 960 
Phe Met Leu Phe Glu Arg Gln Pro Leu Ile Asp Ser Tyr Ser Glu Glu
                965                 970                 975     
Gly Leu Lys Pro Asp Lys Phe Glu Gly Asn Ile Thr Phe Asn Glu Val
            980                 985                 990         
Val Phe Asn Tyr Pro Thr Arg Ala Asn Val Pro Val Leu Gln Gly Leu
        995                 1000                1005            
Ser Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly Ser Ser
    1010                1015                1020                
Gly Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe Tyr Asp
1025                1030                1035                1040
Pro Leu Ala Gly Thr Val Leu Leu Asp Gly Gln Glu Ala Lys Lys Leu
                1045                1050                1055    
Asn Val Gln Trp Leu Arg Ala Gln Leu Gly Ile Val Ser Gln Glu Pro
            1060                1065                1070        
Ile Leu Phe Asp Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn
        1075                1080                1085            
Ser Arg Val Val Ser Gln Asp Glu Ile Val Ser Ala Ala Lys Ala Ala
    1090                1095                1100                
Asn Ile His Pro Phe Ile Glu Thr Leu Pro His Lys Tyr Glu Thr Arg
1105                1110                1115                1120
Val Gly Asp Lys Gly Thr Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile
                1125                1130                1135    
Ala Ile Ala Arg Ala Leu Ile Arg Gln Pro Gln Ile Leu Leu Leu Asp
            1140                1145                1150        
Glu Ala Thr Ser Ala Leu Asp Thr Glu Ser Glu Lys Val Val Gln Glu
        1155                1160                1165            
Ala Leu Asp Lys Ala Arg Glu Gly Arg Thr Cys Ile Val Ile Ala His
    1170                1175                1180                
Arg Leu Ser Thr Ile Gln Asn Ala Asp Leu Ile Val Val Phe Gln Asn
1185                1190                1195                1200
Gly Arg Val Lys Glu His Gly Thr His Gln Gln Leu Leu Ala Gln Lys
                1205                1210                1215    
Gly Ile Tyr Phe Ser Met Val Ser Val Gln Ala Gly Thr Gln Asn Leu
            1220                1225                1230        


<210> 6507
<211> 1279
<212> PRT
<213> Homo sapiens

<400> 6507
Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser
 1               5                  10                  15      
Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys
            20                  25                  30          
Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr
        35                  40                  45              
Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala
    50                  55                  60                  
Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu
65                  70                  75                  80  
Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val
                85                  90                  95      
Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu
            100                 105                 110         
Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu
        115                 120                 125             
Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg
    130                 135                 140                 
Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln
145                 150                 155                 160 
Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg
                165                 170                 175     
Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val
            180                 185                 190         
Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val
        195                 200                 205             
Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser
    210                 215                 220                 
Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala
225                 230                 235                 240 
Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala
                245                 250                 255     
Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln
            260                 265                 270         
Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu
        275                 280                 285             
Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala
    290                 295                 300                 
Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser
305                 310                 315                 320 
Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val
                325                 330                 335     
Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro
            340                 345                 350         
Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe
        355                 360                 365             
Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly
    370                 375                 380                 
His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His
385                 390                 395                 400 
Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn
                405                 410                 415     
Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly
            420                 425                 430         
Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro
        435                 440                 445             
Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn
    450                 455                 460                 
Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val
465                 470                 475                 480 
Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn
                485                 490                 495     
Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr
            500                 505                 510         
Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu
        515                 520                 525             
Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala
    530                 535                 540                 
Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr
545                 550                 555                 560 
Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp
                565                 570                 575     
Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser
            580                 585                 590         
Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile
        595                 600                 605             
Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr
    610                 615                 620                 
Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu
625                 630                 635                 640 
Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn
                645                 650                 655     
Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys
            660                 665                 670         
Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu
        675                 680                 685             
Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn
    690                 695                 700                 
Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala
705                 710                 715                 720 
Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile
                725                 730                 735     
Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn
            740                 745                 750         
Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr
        755                 760                 765             
Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr
    770                 775                 780                 
Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met
785                 790                 795                 800 
Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg
                805                 810                 815     
Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu
            820                 825                 830         
Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile
        835                 840                 845             
Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val
    850                 855                 860                 
Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly
865                 870                 875                 880 
Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala
                885                 890                 895     
Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu
            900                 905                 910         
Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg
        915                 920                 925             
Asn Ser Val Gln Lys Ala His Ile Tyr Gly Ile Thr Phe Ser Ile Ser
    930                 935                 940                 
Gln Ala Phe Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly Ala
945                 950                 955                 960 
Tyr Leu Ile Val Asn Gly His Met Arg Phe Arg Asp Val Ile Leu Val
                965                 970                 975     
Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser Ser
            980                 985                 990         
Phe Ala Pro Asp Tyr Ala Lys Ala Lys Leu Ser Ala Ala His Leu Phe
        995                 1000                1005            
Met Leu Phe Glu Arg Gln Pro Leu Ile Asp Ser Tyr Ser Glu Glu Gly
    1010                1015                1020                
Leu Lys Pro Asp Lys Phe Glu Gly Asn Ile Thr Phe Asn Glu Val Val
1025                1030                1035                1040
Phe Asn Tyr Pro Thr Arg Ala Asn Val Pro Val Leu Gln Gly Leu Ser
                1045                1050                1055    
Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly Ser Ser Gly
            1060                1065                1070        
Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe Tyr Asp Pro
        1075                1080                1085            
Leu Ala Gly Thr Val Leu Leu Asp Gly Gln Glu Ala Lys Lys Leu Asn
    1090                1095                1100                
Val Gln Trp Leu Arg Ala Gln Leu Gly Ile Val Ser Gln Glu Pro Ile
1105                1110                1115                1120
Leu Phe Asp Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn Ser
                1125                1130                1135    
Arg Val Val Ser Gln Asp Glu Ile Val Ser Ala Ala Lys Ala Ala Asn
            1140                1145                1150        
Ile His Pro Phe Ile Glu Thr Leu Pro His Lys Tyr Glu Thr Arg Val
        1155                1160                1165            
Gly Asp Lys Gly Thr Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala
    1170                1175                1180                
Ile Ala Arg Ala Leu Ile Arg Gln Pro Gln Ile Leu Leu Leu Asp Glu
1185                1190                1195                1200
Ala Thr Ser Ala Leu Asp Thr Glu Ser Glu Lys Val Val Gln Glu Ala
                1205                1210                1215    
Leu Asp Lys Ala Arg Glu Gly Arg Thr Cys Ile Val Ile Ala His Arg
            1220                1225                1230        
Leu Ser Thr Ile Gln Asn Ala Asp Leu Ile Val Val Phe Gln Asn Gly
        1235                1240                1245            
Arg Val Lys Glu His Gly Thr His Gln Gln Leu Leu Ala Gln Lys Gly
    1250                1255                1260                
Ile Tyr Phe Ser Met Val Ser Val Gln Ala Gly Thr Gln Asn Leu
1265                1270                1275                


<210> 6508
<211> 351
<212> PRT
<213> Homo sapiens

<400> 6508
Met Thr Trp Ser Ala Thr Ala Arg Gly Ala His Gln Pro Asp Asn Thr
 1               5                  10                  15      
Ala Phe Thr Gln Gln Arg Leu Pro Ala Trp Gln Pro Leu Leu Ser Ala
            20                  25                  30          
Ser Ile Ala Leu Pro Leu Phe Phe Cys Ala Gly Leu Ala Phe Ile Gly
        35                  40                  45              
Leu Gly Leu Gly Leu Tyr Tyr Ser Ser Asn Gly Ile Lys Glu Leu Glu
    50                  55                  60                  
Tyr Asp Tyr Thr Gly Asp Pro Gly Thr Gly Asn Cys Ser Val Cys Ala
65                  70                  75                  80  
Ala Ala Gly Gln Gly Arg Ala Leu Pro Pro Pro Cys Ser Cys Ala Trp
                85                  90                  95      
Tyr Phe Ser Leu Pro Glu Leu Phe Gln Gly Pro Val Tyr Leu Tyr Tyr
            100                 105                 110         
Glu Leu Thr Asn Phe Tyr Gln Asn Asn Arg Arg Tyr Gly Val Ser Arg
        115                 120                 125             
Asp Asp Ala Gln Leu Ser Gly Leu Pro Ser Ala Leu Arg His Pro Val
    130                 135                 140                 
Asn Glu Cys Ala Pro Tyr Gln Arg Ser Ala Ala Gly Leu Pro Ile Ala
145                 150                 155                 160 
Pro Cys Gly Ala Ile Ala Asn Ser Leu Phe Asn Asp Ser Phe Ser Leu
                165                 170                 175     
Trp His Gln Arg Gln Pro Gly Gly Pro Tyr Val Glu Val Pro Leu Asp
            180                 185                 190         
Arg Ser Gly Ile Ala Trp Trp Thr Asp Tyr His Val Lys Phe Arg Asn
        195                 200                 205             
Pro Pro Leu Val Asn Gly Ser Leu Ala Leu Ala Phe Gln Gly Thr Ala
    210                 215                 220                 
Pro Pro Pro Asn Trp Arg Arg Pro Val Tyr Glu Leu Ser Pro Asp Pro
225                 230                 235                 240 
Asn Asn Thr Gly Phe Ile Asn Gln Asp Phe Val Val Trp Met Arg Thr
                245                 250                 255     
Ala Ala Leu Pro Thr Phe Arg Lys Leu Tyr Ala Arg Ile Arg Gln Gly
            260                 265                 270         
Asn Tyr Ser Ala Gly Leu Pro Arg Gly Ala Tyr Arg Val Asn Ile Thr
        275                 280                 285             
Tyr Asn Tyr Pro Val Arg Ala Phe Gly Gly His Lys Leu Leu Ile Phe
    290                 295                 300                 
Ser Ser Ile Ser Trp Met Gly Gly Lys Asn Pro Phe Leu Gly Ile Ala
305                 310                 315                 320 
Tyr Leu Val Val Gly Ser Leu Cys Ile Leu Thr Gly Phe Val Met Leu
                325                 330                 335     
Val Val Tyr Ile Arg Tyr Gln Asp Gln Asp Asp Asp Asp Glu Glu
            340                 345                 350     


<210> 6509
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 6509
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln
    290                 295                 300                 
Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Thr Gln Asp Gly Val Ala
305                 310                 315                 320 
Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu
                325                 330                 335     
Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu
            340                 345                 350         
Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu
        355                 360                 365             
Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu Tyr Phe Val Ile
    370                 375                 380                 
Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Thr Pro
385                 390                 395                 400 
Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Thr Val
                405                 410                 415     
Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr Ile Ser
            420                 425                 430         
Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg
        435                 440                 445             
His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile Cys Ser
    450                 455                 460                 
Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr Val Val Gln Ala
465                 470                 475                 480 
Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe
                485                 490                 495     
Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser
            500                 505                 510         
Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro
        515                 520                 525             
Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu Gly Phe Val Thr
    530                 535                 540                 
Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu
545                 550                 555                 560 
Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser Met Ser
                565                 570                 575     
Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly
            580                 585                 590         
Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys
        595                 600                 605             
Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg
    610                 615                 620                 
Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile
625                 630                 635                 640 
Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp Asp Asn Glu Asn
                645                 650                 655     
Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp
            660                 665                 670         
Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala
        675                 680                 685             
Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg
    690                 695                 700                 
Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly Asp Asp Phe Leu
705                 710                 715                 720 
Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly
                725                 730                 735     
Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val
            740                 745                 750         
Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile
        755                 760                 765             
Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val Ala Val Thr Gly
    770                 775                 780                 
Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe
785                 790                 795                 800 
Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile
                805                 810                 815     
Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp
            820                 825                 830         
Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu
        835                 840                 845             
Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile
    850                 855                 860                 
Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu
865                 870                 875                 880 
Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr
                885                 890                 895     
Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile
            900                 905                 910         
Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu
        915                 920                 925             
Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile
    930                 935                 940                 
Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr
945                 950                 955                 960 
Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile
                965                 970                 975     
Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr
            980                 985                 990         
Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr Phe Ile Cys Gln
        995                 1000                1005            
Ile Phe Ile Val Glu Phe Gly Gly Lys Pro Phe Ser Cys Thr Ser Leu
    1010                1015                1020                
Ser Leu Ser Gln Trp Leu Trp Cys Leu Phe Ile Gly Ile Gly Glu Leu
1025                1030                1035                1040
Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Thr Arg Ser Leu Lys Phe
                1045                1050                1055    
Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu Ile Thr Lys Asp
            1060                1065                1070        
Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met Glu Leu Arg Arg
        1075                1080                1085            
Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile
    1090                1095                1100                
Asp Val Ile Asn Thr Phe Gln Thr Gly Ala Ser Phe Lys Gly Val Leu
1105                1110                1115                1120
Arg Arg Gln Asn Met Gly Gln His Leu Asp Val Lys Leu Val Pro Ser
                1125                1130                1135    
Ser Ser Tyr Val Ala Val Ala Pro Val Lys Ser Ser Pro Thr Thr Ser
            1140                1145                1150        
Val Pro Ala Val Ser Ser Pro Pro Met Gly Asn Gln Ser Gly Gln Ser
        1155                1160                1165            
Val Pro
    1170


<210> 6510
<211> 1220
<212> PRT
<213> Homo sapiens

<400> 6510
Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn
 1               5                  10                  15      
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys
        35                  40                  45              
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys
    50                  55                  60                  
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg
65                  70                  75                  80  
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln
        115                 120                 125             
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu
    130                 135                 140                 
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu
145                 150                 155                 160 
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser
                165                 170                 175     
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln
            180                 185                 190         
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala
        195                 200                 205             
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu
    210                 215                 220                 
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu
225                 230                 235                 240 
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys
                245                 250                 255     
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg
            260                 265                 270         
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe
        275                 280                 285             
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys
    290                 295                 300                 
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg
305                 310                 315                 320 
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu
                325                 330                 335     
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala
            340                 345                 350         
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
        355                 360                 365             
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr
    370                 375                 380                 
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln
385                 390                 395                 400 
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe
                405                 410                 415     
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
            420                 425                 430         
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
        435                 440                 445             
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
    450                 455                 460                 
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
465                 470                 475                 480 
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His
                485                 490                 495     
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser
            500                 505                 510         
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile
        515                 520                 525             
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys
    530                 535                 540                 
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr
545                 550                 555                 560 
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr
                565                 570                 575     
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser
            580                 585                 590         
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu
        595                 600                 605             
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe
    610                 615                 620                 
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met
625                 630                 635                 640 
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro
                645                 650                 655     
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr
            660                 665                 670         
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro
        675                 680                 685             
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val
    690                 695                 700                 
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr
705                 710                 715                 720 
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly
                725                 730                 735     
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln
            740                 745                 750         
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser
        755                 760                 765             
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr
    770                 775                 780                 
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn
785                 790                 795                 800 
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile
                805                 810                 815     
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp
            820                 825                 830         
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val
        835                 840                 845             
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val
    850                 855                 860                 
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser
865                 870                 875                 880 
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr
                885                 890                 895     
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu
            900                 905                 910         
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met
        915                 920                 925             
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe
    930                 935                 940                 
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg
945                 950                 955                 960 
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe
                965                 970                 975     
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys
            980                 985                 990         
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile
        995                 1000                1005            
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val
    1010                1015                1020                
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln
1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln
                1045                1050                1055    
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala
            1060                1065                1070        
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu
        1075                1080                1085            
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln
    1090                1095                1100                
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val
1105                1110                1115                1120
Val Asn Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu
                1125                1130                1135    
Ser Arg Ser Ser Ile His Asn Phe Met Thr His Pro Glu Phe Arg Ile
            1140                1145                1150        
Glu Asp Ser Glu Pro His Ile Pro Leu Ile Asp Asp Thr Asp Ala Glu
        1155                1160                1165            
Asp Asp Ala Pro Thr Lys Arg Asn Ser Ser Pro Pro Pro Ser Pro Asn
    1170                1175                1180                
Lys Asn Asn Asn Ala Val Asp Ser Gly Ile His Leu Thr Ile Glu Met
1185                1190                1195                1200
Asn Lys Ser Ala Thr Ser Ser Ser Pro Gly Ser Pro Leu His Ser Leu
                1205                1210                1215    
Glu Thr Ser Leu
            1220


<210> 6511
<211> 1158
<212> PRT
<213> Homo sapiens

<400> 6511
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Ala Lys Thr Gln
    290                 295                 300                 
Asp Gly Val Ala Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile
305                 310                 315                 320 
Asp Asn Glu Glu Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu
                325                 330                 335     
Lys Ser Val Leu Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly
            340                 345                 350         
Lys Ala Gly Leu Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu
        355                 360                 365             
Tyr Phe Val Ile Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro
    370                 375                 380                 
Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile
385                 390                 395                 400 
Gly Ile Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala
                405                 410                 415     
Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn
            420                 425                 430         
Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr
        435                 440                 445             
Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr
    450                 455                 460                 
Val Val Gln Ala Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser
465                 470                 475                 480 
Pro Asp Val Phe Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile
                485                 490                 495     
Ser Ile Asn Ser Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu
            500                 505                 510         
Gly Gly Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu
        515                 520                 525             
Gly Phe Val Thr Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu
    530                 535                 540                 
Val Pro Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg
545                 550                 555                 560 
Lys Ser Met Ser Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met
                565                 570                 575     
Tyr Ser Lys Gly Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile
            580                 585                 590         
Leu Asp Arg Lys Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp
        595                 600                 605             
Asp Met Val Arg Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg
    610                 615                 620                 
Thr Ile Cys Ile Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp
625                 630                 635                 640 
Asp Asn Glu Asn Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val
                645                 650                 655     
Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys
            660                 665                 670         
Cys Lys Gln Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile
        675                 680                 685             
Asn Thr Ala Arg Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly
    690                 695                 700                 
Asp Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg
705                 710                 715                 720 
Asn Glu Lys Gly Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro
                725                 730                 735     
Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu
            740                 745                 750         
Val Lys Gly Ile Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val
        755                 760                 765             
Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala
    770                 775                 780                 
Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu
785                 790                 795                 800 
Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys
                805                 810                 815     
Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu
            820                 825                 830         
Gln Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr
        835                 840                 845             
Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu
    850                 855                 860                 
Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr
865                 870                 875                 880 
Glu Pro Pro Thr Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn
                885                 890                 895     
Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala
            900                 905                 910         
Phe Tyr Gln Leu Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys
        915                 920                 925             
Phe Phe Asp Ile Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro
    930                 935                 940                 
Ser Gln His Tyr Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu
945                 950                 955                 960 
Phe Asn Glu Ile Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe
                965                 970                 975     
Ser Gly Ile Tyr Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr
            980                 985                 990         
Phe Ile Cys Gln Ile Phe Ile Val Glu Phe Gly Gly Lys Pro Phe Ser
        995                 1000                1005            
Cys Thr Ser Leu Ser Leu Ser Gln Trp Leu Trp Cys Leu Phe Ile Gly
    1010                1015                1020                
Ile Gly Glu Leu Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Thr Arg
1025                1030                1035                1040
Ser Leu Lys Phe Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu
                1045                1050                1055    
Ile Thr Lys Asp Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met
            1060                1065                1070        
Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile
        1075                1080                1085            
Gln Thr Gln Ile Asp Val Ile Asn Thr Phe Gln Thr Gly Ala Ser Phe
    1090                1095                1100                
Lys Gly Val Leu Arg Arg Gln Asn Met Gly Gln His Leu Asp Val Lys
1105                1110                1115                1120
Leu Val Pro Ser Ser Ser Tyr Val Ala Val Ala Pro Val Lys Ser Ser
                1125                1130                1135    
Pro Thr Thr Ser Val Pro Ala Val Ser Ser Pro Pro Met Gly Asn Gln
            1140                1145                1150        
Ser Gly Gln Ser Val Pro
        1155            


<210> 6512
<211> 1206
<212> PRT
<213> Homo sapiens

<400> 6512
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Ala Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu
305                 310                 315                 320 
Lys Ser Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala
                325                 330                 335     
Asn Ala Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
            340                 345                 350         
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr
        355                 360                 365             
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu
    370                 375                 380                 
Gly Arg Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe
385                 390                 395                 400 
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
                405                 410                 415     
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
            420                 425                 430         
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
        435                 440                 445             
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
    450                 455                 460                 
Thr Thr Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His
465                 470                 475                 480 
Tyr Lys Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp
                485                 490                 495     
Leu Leu Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile
            500                 505                 510         
Leu Pro Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys
        515                 520                 525             
Thr Glu Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe
    530                 535                 540                 
Gln Pro Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr
545                 550                 555                 560 
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro
                565                 570                 575     
Asp Gly Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu
            580                 585                 590         
Lys Lys Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe
        595                 600                 605             
Arg Pro Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met
    610                 615                 620                 
Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr
625                 630                 635                 640 
Ala Gly Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp
                645                 650                 655     
Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu
            660                 665                 670         
Val Pro Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg
        675                 680                 685             
Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys
    690                 695                 700                 
Cys Gly Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys
705                 710                 715                 720 
Glu Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu
                725                 730                 735     
Arg Leu Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser
            740                 745                 750         
Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr
        755                 760                 765             
Gly Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp
    770                 775                 780                 
Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala
785                 790                 795                 800 
Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp
                805                 810                 815     
Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr
            820                 825                 830         
Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val
        835                 840                 845             
Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro
    850                 855                 860                 
Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe
865                 870                 875                 880 
Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu
                885                 890                 895     
Arg Lys Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met
            900                 905                 910         
Lys Asn Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr
        915                 920                 925             
Leu Leu Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn
    930                 935                 940                 
Ala Pro Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn
945                 950                 955                 960 
Thr Phe Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile
                965                 970                 975     
His Gly Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe
            980                 985                 990         
Cys Thr Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln
        995                 1000                1005            
Phe Gly Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp
    1010                1015                1020                
Leu Trp Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val
1025                1030                1035                1040
Ile Ala Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly
                1045                1050                1055    
His Gly Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly
            1060                1065                1070        
Glu Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile
        1075                1080                1085            
Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val
    1090                1095                1100                
Lys Ala Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser
1105                1110                1115                1120
Lys Thr Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn
                1125                1130                1135    
Asp Tyr Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu
            1140                1145                1150        
Asn Glu Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn
        1155                1160                1165            
Asn Asn Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys
    1170                1175                1180                
Ser Ala Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His
1185                1190                1195                1200
Ser Val Glu Thr Ser Leu
                1205    


<210> 6513
<211> 1193
<212> PRT
<213> Homo sapiens

<400> 6513
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Ala Lys Thr Gln
    290                 295                 300                 
Asp Gly Val Ala Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile
305                 310                 315                 320 
Asp Asn Glu Glu Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu
                325                 330                 335     
Lys Ser Val Leu Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly
            340                 345                 350         
Lys Ala Gly Leu Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu
        355                 360                 365             
Tyr Phe Val Ile Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro
    370                 375                 380                 
Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile
385                 390                 395                 400 
Gly Ile Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala
                405                 410                 415     
Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn
            420                 425                 430         
Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr
        435                 440                 445             
Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr
    450                 455                 460                 
Val Val Gln Ala Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser
465                 470                 475                 480 
Pro Asp Val Phe Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile
                485                 490                 495     
Ser Ile Asn Ser Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu
            500                 505                 510         
Gly Gly Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu
        515                 520                 525             
Gly Phe Val Thr Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu
    530                 535                 540                 
Val Pro Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg
545                 550                 555                 560 
Lys Ser Met Ser Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met
                565                 570                 575     
Tyr Ser Lys Gly Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile
            580                 585                 590         
Leu Asp Arg Lys Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp
        595                 600                 605             
Asp Met Val Arg Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg
    610                 615                 620                 
Thr Ile Cys Ile Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp
625                 630                 635                 640 
Asp Asn Glu Asn Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val
                645                 650                 655     
Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys
            660                 665                 670         
Cys Lys Gln Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile
        675                 680                 685             
Asn Thr Ala Arg Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly
    690                 695                 700                 
Asp Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg
705                 710                 715                 720 
Asn Glu Lys Gly Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro
                725                 730                 735     
Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu
            740                 745                 750         
Val Lys Gly Ile Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val
        755                 760                 765             
Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala
    770                 775                 780                 
Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu
785                 790                 795                 800 
Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys
                805                 810                 815     
Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu
            820                 825                 830         
Gln Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr
        835                 840                 845             
Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu
    850                 855                 860                 
Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr
865                 870                 875                 880 
Glu Pro Pro Thr Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn
                885                 890                 895     
Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala
            900                 905                 910         
Phe Tyr Gln Leu Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys
        915                 920                 925             
Phe Phe Asp Ile Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro
    930                 935                 940                 
Ser Gln His Tyr Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu
945                 950                 955                 960 
Phe Asn Glu Ile Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe
                965                 970                 975     
Ser Gly Ile Tyr Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr
            980                 985                 990         
Phe Ile Cys Gln Ile Phe Ile Val Glu Phe Gly Gly Lys Pro Phe Ser
        995                 1000                1005            
Cys Thr Ser Leu Ser Leu Ser Gln Trp Leu Trp Cys Leu Phe Ile Gly
    1010                1015                1020                
Ile Gly Glu Leu Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Thr Arg
1025                1030                1035                1040
Ser Leu Lys Phe Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu
                1045                1050                1055    
Ile Thr Lys Asp Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met
            1060                1065                1070        
Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile
        1075                1080                1085            
Gln Thr Gln Ile Lys Val Val Lys Ala Phe His Ser Ser Leu His Glu
    1090                1095                1100                
Ser Ile Gln Lys Pro Tyr Asn Gln Lys Ser Ile His Ser Phe Met Thr
1105                1110                1115                1120
His Pro Glu Phe Ala Ile Glu Glu Glu Leu Pro Arg Thr Pro Leu Leu
                1125                1130                1135    
Asp Glu Glu Glu Glu Glu Asn Pro Asp Lys Ala Ser Lys Phe Gly Thr
            1140                1145                1150        
Arg Val Leu Leu Leu Asp Gly Glu Val Thr Pro Tyr Ala Asn Thr Asn
        1155                1160                1165            
Asn Asn Ala Val Asp Cys Asn Gln Val Gln Leu Pro Gln Ser Asp Ser
    1170                1175                1180                
Ser Leu Gln Ser Leu Glu Thr Ser Val
1185                1190            


<210> 6514
<211> 1241
<212> PRT
<213> Homo sapiens

<400> 6514
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln
    290                 295                 300                 
Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Thr Gln Asp Gly Val Ala
305                 310                 315                 320 
Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu
                325                 330                 335     
Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu
            340                 345                 350         
Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu
        355                 360                 365             
Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu Tyr Phe Val Ile
    370                 375                 380                 
Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Thr Pro
385                 390                 395                 400 
Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Thr Val
                405                 410                 415     
Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr Ile Ser
            420                 425                 430         
Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg
        435                 440                 445             
His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile Cys Ser
    450                 455                 460                 
Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr Val Val Gln Ala
465                 470                 475                 480 
Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe
                485                 490                 495     
Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser
            500                 505                 510         
Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro
        515                 520                 525             
Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu Gly Phe Val Thr
    530                 535                 540                 
Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu
545                 550                 555                 560 
Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser Met Ser
                565                 570                 575     
Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly
            580                 585                 590         
Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys
        595                 600                 605             
Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg
    610                 615                 620                 
Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile
625                 630                 635                 640 
Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp Asp Asn Glu Asn
                645                 650                 655     
Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp
            660                 665                 670         
Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala
        675                 680                 685             
Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg
    690                 695                 700                 
Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly Asp Asp Phe Leu
705                 710                 715                 720 
Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly
                725                 730                 735     
Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val
            740                 745                 750         
Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile
        755                 760                 765             
Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val Ala Val Thr Gly
    770                 775                 780                 
Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe
785                 790                 795                 800 
Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile
                805                 810                 815     
Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp
            820                 825                 830         
Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu
        835                 840                 845             
Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile
    850                 855                 860                 
Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu
865                 870                 875                 880 
Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr
                885                 890                 895     
Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile
            900                 905                 910         
Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu
        915                 920                 925             
Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile
    930                 935                 940                 
Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr
945                 950                 955                 960 
Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile
                965                 970                 975     
Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr
            980                 985                 990         
Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr Phe Ile Cys Gln
        995                 1000                1005            
Ile Phe Ile Val Glu Phe Gly Gly Lys Pro Phe Ser Cys Thr Ser Leu
    1010                1015                1020                
Ser Leu Ser Gln Trp Leu Trp Cys Leu Phe Ile Gly Ile Gly Glu Leu
1025                1030                1035                1040
Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Thr Arg Ser Leu Lys Phe
                1045                1050                1055    
Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu Ile Thr Lys Asp
            1060                1065                1070        
Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met Glu Leu Arg Arg
        1075                1080                1085            
Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile
    1090                1095                1100                
Asp Val Ile Asn Thr Phe Gln Thr Gly Ala Ser Phe Lys Gly Val Leu
1105                1110                1115                1120
Arg Arg Gln Asn Met Gly Gln His Leu Asp Val Lys Leu Val Pro Ser
                1125                1130                1135    
Ser Ser Tyr Ile Lys Val Val Lys Ala Phe His Ser Ser Leu His Glu
            1140                1145                1150        
Ser Ile Gln Lys Pro Tyr Asn Gln Lys Ser Ile His Ser Phe Met Thr
        1155                1160                1165            
His Pro Glu Phe Ala Ile Glu Glu Glu Leu Pro Arg Thr Pro Leu Leu
    1170                1175                1180                
Asp Glu Glu Glu Glu Glu Asn Pro Asp Lys Ala Ser Lys Phe Gly Thr
1185                1190                1195                1200
Arg Val Leu Leu Leu Asp Gly Glu Val Thr Pro Tyr Ala Asn Thr Asn
                1205                1210                1215    
Asn Asn Ala Val Asp Cys Asn Gln Val Gln Leu Pro Gln Ser Asp Ser
            1220                1225                1230        
Ser Leu Gln Ser Leu Glu Thr Ser Val
        1235                1240    


<210> 6515
<211> 1115
<212> PRT
<213> Homo sapiens

<400> 6515
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Ala Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu
305                 310                 315                 320 
Lys Ser Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala
                325                 330                 335     
Asn Ala Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
            340                 345                 350         
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr
        355                 360                 365             
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu
    370                 375                 380                 
Gly Arg Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe
385                 390                 395                 400 
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
                405                 410                 415     
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
            420                 425                 430         
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
        435                 440                 445             
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
    450                 455                 460                 
Thr Thr Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His
465                 470                 475                 480 
Tyr Lys Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp
                485                 490                 495     
Leu Leu Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile
            500                 505                 510         
Leu Pro Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys
        515                 520                 525             
Thr Glu Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe
    530                 535                 540                 
Gln Pro Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr
545                 550                 555                 560 
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro
                565                 570                 575     
Asp Gly Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu
            580                 585                 590         
Lys Lys Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe
        595                 600                 605             
Arg Pro Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met
    610                 615                 620                 
Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr
625                 630                 635                 640 
Ala Gly Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp
                645                 650                 655     
Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu
            660                 665                 670         
Val Pro Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg
        675                 680                 685             
Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys
    690                 695                 700                 
Cys Gly Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys
705                 710                 715                 720 
Glu Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu
                725                 730                 735     
Arg Leu Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser
            740                 745                 750         
Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr
        755                 760                 765             
Gly Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp
    770                 775                 780                 
Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala
785                 790                 795                 800 
Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp
                805                 810                 815     
Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr
            820                 825                 830         
Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val
        835                 840                 845             
Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro
    850                 855                 860                 
Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe
865                 870                 875                 880 
Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu
                885                 890                 895     
Arg Lys Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met
            900                 905                 910         
Lys Asn Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr
        915                 920                 925             
Leu Leu Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn
    930                 935                 940                 
Ala Pro Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn
945                 950                 955                 960 
Thr Phe Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile
                965                 970                 975     
His Gly Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe
            980                 985                 990         
Cys Thr Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln
        995                 1000                1005            
Phe Gly Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp
    1010                1015                1020                
Leu Trp Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val
1025                1030                1035                1040
Ile Ala Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly
                1045                1050                1055    
His Gly Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly
            1060                1065                1070        
Glu Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile
        1075                1080                1085            
Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Val Cys Trp Asp
    1090                1095                1100                
Gly Lys Lys Met Leu Arg Thr Thr Glu Val Gly
1105                1110                1115


<210> 6516
<211> 1173
<212> PRT
<213> Homo sapiens

<400> 6516
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305                 310                 315                 320 
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
                325                 330                 335     
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
            340                 345                 350         
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
        355                 360                 365             
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
    370                 375                 380                 
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385                 390                 395                 400 
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
                405                 410                 415     
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
            420                 425                 430         
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
        435                 440                 445             
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
    450                 455                 460                 
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465                 470                 475                 480 
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
                485                 490                 495     
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
            500                 505                 510         
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
        515                 520                 525             
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
    530                 535                 540                 
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545                 550                 555                 560 
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
                565                 570                 575     
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly
            580                 585                 590         
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
        595                 600                 605             
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
    610                 615                 620                 
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625                 630                 635                 640 
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly
                645                 650                 655     
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
            660                 665                 670         
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
        675                 680                 685             
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
    690                 695                 700                 
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705                 710                 715                 720 
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
                725                 730                 735     
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
            740                 745                 750         
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
        755                 760                 765             
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
    770                 775                 780                 
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785                 790                 795                 800 
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
                805                 810                 815     
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
            820                 825                 830         
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
        835                 840                 845             
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
    850                 855                 860                 
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865                 870                 875                 880 
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
                885                 890                 895     
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
            900                 905                 910         
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
        915                 920                 925             
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
    930                 935                 940                 
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945                 950                 955                 960 
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
                965                 970                 975     
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
            980                 985                 990         
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
        995                 1000                1005            
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
    1010                1015                1020                
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
                1045                1050                1055    
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
            1060                1065                1070        
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
        1075                1080                1085            
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
    1090                1095                1100                
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr
1105                1110                1115                1120
Phe Lys Arg Ser Gly Ser Val Gln Gly Ala Val Arg Arg Arg Ser Ser
                1125                1130                1135    
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His
            1140                1145                1150        
Ala Ile Leu Ser Ala Ala Asn Pro Thr Ser Ala Ala Gly Asn Pro Gly
        1155                1160                1165            
Gly Glu Ser Val Pro
    1170            


<210> 6517
<211> 1134
<212> PRT
<213> Homo sapiens

<400> 6517
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln
    290                 295                 300                 
Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Thr Gln Asp Gly Val Ala
305                 310                 315                 320 
Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu
                325                 330                 335     
Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu
            340                 345                 350         
Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu
        355                 360                 365             
Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu Tyr Phe Val Ile
    370                 375                 380                 
Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Thr Pro
385                 390                 395                 400 
Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Thr Val
                405                 410                 415     
Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr Ile Ser
            420                 425                 430         
Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg
        435                 440                 445             
His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile Cys Ser
    450                 455                 460                 
Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr Val Val Gln Ala
465                 470                 475                 480 
Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe
                485                 490                 495     
Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser
            500                 505                 510         
Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro
        515                 520                 525             
Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu Gly Phe Val Thr
    530                 535                 540                 
Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu
545                 550                 555                 560 
Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser Met Ser
                565                 570                 575     
Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly
            580                 585                 590         
Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys
        595                 600                 605             
Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg
    610                 615                 620                 
Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile
625                 630                 635                 640 
Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp Asp Asn Glu Asn
                645                 650                 655     
Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp
            660                 665                 670         
Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala
        675                 680                 685             
Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg
    690                 695                 700                 
Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly Asp Asp Phe Leu
705                 710                 715                 720 
Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly
                725                 730                 735     
Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val
            740                 745                 750         
Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile
        755                 760                 765             
Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val Ala Val Thr Gly
    770                 775                 780                 
Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe
785                 790                 795                 800 
Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile
                805                 810                 815     
Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp
            820                 825                 830         
Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu
        835                 840                 845             
Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile
    850                 855                 860                 
Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu
865                 870                 875                 880 
Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr
                885                 890                 895     
Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile
            900                 905                 910         
Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu
        915                 920                 925             
Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile
    930                 935                 940                 
Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr
945                 950                 955                 960 
Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile
                965                 970                 975     
Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr
            980                 985                 990         
Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr Phe Ile Cys Gln
        995                 1000                1005            
Phe Ile Ser Ala Ile Pro Thr Arg Ser Leu Lys Phe Leu Lys Glu Ala
    1010                1015                1020                
Gly His Gly Thr Thr Lys Glu Glu Ile Thr Lys Asp Ala Glu Gly Leu
1025                1030                1035                1040
Asp Glu Ile Asp His Ala Glu Met Glu Leu Arg Arg Gly Gln Ile Leu
                1045                1050                1055    
Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Asp Val Ile Asn
            1060                1065                1070        
Thr Phe Gln Thr Gly Ala Ser Phe Lys Gly Val Leu Arg Arg Gln Asn
        1075                1080                1085            
Met Gly Gln His Leu Asp Val Lys Leu Val Pro Ser Ser Ser Tyr Val
    1090                1095                1100                
Ala Val Ala Pro Val Lys Ser Ser Pro Thr Thr Ser Val Pro Ala Val
1105                1110                1115                1120
Ser Ser Pro Pro Met Gly Asn Gln Ser Gly Gln Ser Val Pro
                1125                1130                


<210> 6518
<211> 1176
<212> PRT
<213> Homo sapiens

<400> 6518
Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn
 1               5                  10                  15      
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys
        35                  40                  45              
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys
    50                  55                  60                  
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg
65                  70                  75                  80  
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln
        115                 120                 125             
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu
    130                 135                 140                 
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu
145                 150                 155                 160 
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser
                165                 170                 175     
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln
            180                 185                 190         
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala
        195                 200                 205             
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu
    210                 215                 220                 
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu
225                 230                 235                 240 
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys
                245                 250                 255     
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg
            260                 265                 270         
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe
        275                 280                 285             
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys
    290                 295                 300                 
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg
305                 310                 315                 320 
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu
                325                 330                 335     
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala
            340                 345                 350         
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
        355                 360                 365             
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr
    370                 375                 380                 
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln
385                 390                 395                 400 
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe
                405                 410                 415     
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
            420                 425                 430         
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
        435                 440                 445             
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
    450                 455                 460                 
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
465                 470                 475                 480 
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His
                485                 490                 495     
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser
            500                 505                 510         
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile
        515                 520                 525             
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys
    530                 535                 540                 
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr
545                 550                 555                 560 
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr
                565                 570                 575     
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser
            580                 585                 590         
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu
        595                 600                 605             
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe
    610                 615                 620                 
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met
625                 630                 635                 640 
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro
                645                 650                 655     
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr
            660                 665                 670         
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro
        675                 680                 685             
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val
    690                 695                 700                 
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr
705                 710                 715                 720 
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly
                725                 730                 735     
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln
            740                 745                 750         
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser
        755                 760                 765             
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr
    770                 775                 780                 
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn
785                 790                 795                 800 
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile
                805                 810                 815     
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp
            820                 825                 830         
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val
        835                 840                 845             
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val
    850                 855                 860                 
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser
865                 870                 875                 880 
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr
                885                 890                 895     
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu
            900                 905                 910         
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met
        915                 920                 925             
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe
    930                 935                 940                 
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg
945                 950                 955                 960 
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe
                965                 970                 975     
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys
            980                 985                 990         
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile
        995                 1000                1005            
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val
    1010                1015                1020                
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln
1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln
                1045                1050                1055    
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala
            1060                1065                1070        
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu
        1075                1080                1085            
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln
    1090                1095                1100                
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val
1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Ser Ser Ile Gln Gly Ala Leu Arg Arg
                1125                1130                1135    
Gln Pro Ser Ile Ala Ser Gln His His Asp Val Thr Asn Ile Ser Thr
            1140                1145                1150        
Pro Thr His Val Val Phe Ser Ser Ser Thr Ala Ser Thr Thr Val Gly
        1155                1160                1165            
Tyr Ser Ser Gly Glu Cys Ile Ser
    1170                1175    


<210> 6519
<211> 1154
<212> PRT
<213> Homo sapiens

<400> 6519
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Ala Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu
305                 310                 315                 320 
Lys Ser Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala
                325                 330                 335     
Asn Ala Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
            340                 345                 350         
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr
        355                 360                 365             
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu
    370                 375                 380                 
Gly Arg Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe
385                 390                 395                 400 
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
                405                 410                 415     
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
            420                 425                 430         
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
        435                 440                 445             
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
    450                 455                 460                 
Thr Thr Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His
465                 470                 475                 480 
Tyr Lys Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp
                485                 490                 495     
Leu Leu Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile
            500                 505                 510         
Leu Pro Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys
        515                 520                 525             
Thr Glu Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe
    530                 535                 540                 
Gln Pro Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr
545                 550                 555                 560 
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro
                565                 570                 575     
Asp Gly Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu
            580                 585                 590         
Lys Lys Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe
        595                 600                 605             
Arg Pro Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met
    610                 615                 620                 
Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr
625                 630                 635                 640 
Ala Gly Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp
                645                 650                 655     
Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu
            660                 665                 670         
Val Pro Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg
        675                 680                 685             
Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys
    690                 695                 700                 
Cys Gly Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys
705                 710                 715                 720 
Glu Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu
                725                 730                 735     
Arg Leu Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser
            740                 745                 750         
Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr
        755                 760                 765             
Gly Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp
    770                 775                 780                 
Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala
785                 790                 795                 800 
Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp
                805                 810                 815     
Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr
            820                 825                 830         
Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val
        835                 840                 845             
Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro
    850                 855                 860                 
Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe
865                 870                 875                 880 
Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu
                885                 890                 895     
Arg Lys Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met
            900                 905                 910         
Lys Asn Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr
        915                 920                 925             
Leu Leu Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn
    930                 935                 940                 
Ala Pro Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn
945                 950                 955                 960 
Thr Phe Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile
                965                 970                 975     
His Gly Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe
            980                 985                 990         
Cys Thr Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln
        995                 1000                1005            
Phe Gly Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp
    1010                1015                1020                
Leu Trp Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val
1025                1030                1035                1040
Ile Ala Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly
                1045                1050                1055    
His Gly Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly
            1060                1065                1070        
Glu Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile
        1075                1080                1085            
Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val
    1090                1095                1100                
Ser Thr Phe Lys Arg Ser Gly Ser Val Gln Gly Ala Val Arg Arg Arg
1105                1110                1115                1120
Ser Ser Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro
                1125                1130                1135    
Thr His Ala Ile Leu Ser Ala Ala Asn Pro Thr Ser Ala Ala Gly Ser
            1140                1145                1150        
Glu Ser
        


<210> 6520
<211> 1220
<212> PRT
<213> Homo sapiens

<400> 6520
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305                 310                 315                 320 
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
                325                 330                 335     
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
            340                 345                 350         
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
        355                 360                 365             
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
    370                 375                 380                 
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385                 390                 395                 400 
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
                405                 410                 415     
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
            420                 425                 430         
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
        435                 440                 445             
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
    450                 455                 460                 
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465                 470                 475                 480 
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
                485                 490                 495     
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
            500                 505                 510         
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
        515                 520                 525             
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
    530                 535                 540                 
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545                 550                 555                 560 
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
                565                 570                 575     
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly
            580                 585                 590         
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
        595                 600                 605             
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
    610                 615                 620                 
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625                 630                 635                 640 
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly
                645                 650                 655     
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
            660                 665                 670         
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
        675                 680                 685             
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
    690                 695                 700                 
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705                 710                 715                 720 
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
                725                 730                 735     
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
            740                 745                 750         
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
        755                 760                 765             
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
    770                 775                 780                 
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785                 790                 795                 800 
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
                805                 810                 815     
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
            820                 825                 830         
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
        835                 840                 845             
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
    850                 855                 860                 
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865                 870                 875                 880 
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
                885                 890                 895     
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
            900                 905                 910         
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
        915                 920                 925             
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
    930                 935                 940                 
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945                 950                 955                 960 
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
                965                 970                 975     
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
            980                 985                 990         
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
        995                 1000                1005            
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
    1010                1015                1020                
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
                1045                1050                1055    
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
            1060                1065                1070        
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
        1075                1080                1085            
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
    1090                1095                1100                
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala
1105                1110                1115                1120
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Lys Thr
                1125                1130                1135    
Ser Ile His Asn Phe Met Ala Thr Pro Glu Phe Leu Ile Asn Asp Tyr
            1140                1145                1150        
Thr His Asn Ile Pro Leu Ile Asp Asp Thr Asp Val Asp Glu Asn Glu
        1155                1160                1165            
Glu Arg Leu Arg Ala Pro Pro Pro Pro Ser Pro Asn Gln Asn Asn Asn
    1170                1175                1180                
Ala Ile Asp Ser Gly Ile Tyr Leu Thr Thr His Val Thr Lys Ser Ala
1185                1190                1195                1200
Thr Ser Ser Val Phe Ser Ser Ser Pro Gly Ser Pro Leu His Ser Val
                1205                1210                1215    
Glu Thr Ser Leu
            1220


<210> 6521
<211> 1168
<212> PRT
<213> Homo sapiens

<400> 6521
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305                 310                 315                 320 
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
                325                 330                 335     
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
            340                 345                 350         
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
        355                 360                 365             
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
    370                 375                 380                 
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385                 390                 395                 400 
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
                405                 410                 415     
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
            420                 425                 430         
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
        435                 440                 445             
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
    450                 455                 460                 
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465                 470                 475                 480 
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
                485                 490                 495     
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
            500                 505                 510         
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
        515                 520                 525             
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
    530                 535                 540                 
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545                 550                 555                 560 
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
                565                 570                 575     
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly
            580                 585                 590         
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
        595                 600                 605             
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
    610                 615                 620                 
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625                 630                 635                 640 
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly
                645                 650                 655     
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
            660                 665                 670         
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
        675                 680                 685             
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
    690                 695                 700                 
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705                 710                 715                 720 
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
                725                 730                 735     
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
            740                 745                 750         
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
        755                 760                 765             
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
    770                 775                 780                 
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785                 790                 795                 800 
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
                805                 810                 815     
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
            820                 825                 830         
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
        835                 840                 845             
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
    850                 855                 860                 
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865                 870                 875                 880 
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
                885                 890                 895     
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
            900                 905                 910         
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
        915                 920                 925             
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
    930                 935                 940                 
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945                 950                 955                 960 
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
                965                 970                 975     
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
            980                 985                 990         
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
        995                 1000                1005            
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
    1010                1015                1020                
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
                1045                1050                1055    
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
            1060                1065                1070        
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
        1075                1080                1085            
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
    1090                1095                1100                
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val Ser Thr
1105                1110                1115                1120
Phe Lys Arg Ser Gly Ser Val Gln Gly Ala Val Arg Arg Arg Ser Ser
                1125                1130                1135    
Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro Thr His
            1140                1145                1150        
Ala Ile Leu Ser Ala Ala Asn Pro Thr Ser Ala Ala Gly Ser Glu Ser
        1155                1160                1165            


<210> 6522
<211> 1122
<212> PRT
<213> Homo sapiens

<400> 6522
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Ala Lys Thr Gln
    290                 295                 300                 
Asp Gly Val Ala Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile
305                 310                 315                 320 
Asp Asn Glu Glu Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu
                325                 330                 335     
Lys Ser Val Leu Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly
            340                 345                 350         
Lys Ala Gly Leu Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu
        355                 360                 365             
Tyr Phe Val Ile Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro
    370                 375                 380                 
Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile
385                 390                 395                 400 
Gly Ile Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala
                405                 410                 415     
Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn
            420                 425                 430         
Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr
        435                 440                 445             
Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr
    450                 455                 460                 
Val Val Gln Ala Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser
465                 470                 475                 480 
Pro Asp Val Phe Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile
                485                 490                 495     
Ser Ile Asn Ser Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu
            500                 505                 510         
Gly Gly Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu
        515                 520                 525             
Gly Phe Val Thr Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu
    530                 535                 540                 
Val Pro Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg
545                 550                 555                 560 
Lys Ser Met Ser Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met
                565                 570                 575     
Tyr Ser Lys Gly Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile
            580                 585                 590         
Leu Asp Arg Lys Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp
        595                 600                 605             
Asp Met Val Arg Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg
    610                 615                 620                 
Thr Ile Cys Ile Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp
625                 630                 635                 640 
Asp Asn Glu Asn Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val
                645                 650                 655     
Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys
            660                 665                 670         
Cys Lys Gln Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile
        675                 680                 685             
Asn Thr Ala Arg Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly
    690                 695                 700                 
Asp Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg
705                 710                 715                 720 
Asn Glu Lys Gly Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro
                725                 730                 735     
Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu
            740                 745                 750         
Val Lys Gly Ile Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val
        755                 760                 765             
Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala
    770                 775                 780                 
Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu
785                 790                 795                 800 
Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys
                805                 810                 815     
Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu
            820                 825                 830         
Gln Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr
        835                 840                 845             
Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu
    850                 855                 860                 
Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr
865                 870                 875                 880 
Glu Pro Pro Thr Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn
                885                 890                 895     
Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala
            900                 905                 910         
Phe Tyr Gln Leu Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys
        915                 920                 925             
Phe Phe Asp Ile Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro
    930                 935                 940                 
Ser Gln His Tyr Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu
945                 950                 955                 960 
Phe Asn Glu Ile Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe
                965                 970                 975     
Ser Gly Ile Tyr Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr
            980                 985                 990         
Phe Ile Cys Gln Phe Ile Ser Ala Ile Pro Thr Arg Ser Leu Lys Phe
        995                 1000                1005            
Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu Ile Thr Lys Asp
    1010                1015                1020                
Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met Glu Leu Arg Arg
1025                1030                1035                1040
Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile
                1045                1050                1055    
Asp Val Ile Asn Thr Phe Gln Thr Gly Ala Ser Phe Lys Gly Val Leu
            1060                1065                1070        
Arg Arg Gln Asn Met Gly Gln His Leu Asp Val Lys Leu Val Pro Ser
        1075                1080                1085            
Ser Ser Tyr Val Ala Val Ala Pro Val Lys Ser Ser Pro Thr Thr Ser
    1090                1095                1100                
Val Pro Ala Val Ser Ser Pro Pro Met Gly Asn Gln Ser Gly Gln Ser
1105                1110                1115                1120
Val Pro
        


<210> 6523
<211> 1258
<212> PRT
<213> Homo sapiens

<400> 6523
Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn
 1               5                  10                  15      
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys
        35                  40                  45              
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys
    50                  55                  60                  
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg
65                  70                  75                  80  
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln
        115                 120                 125             
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu
    130                 135                 140                 
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu
145                 150                 155                 160 
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser
                165                 170                 175     
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln
            180                 185                 190         
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala
        195                 200                 205             
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu
    210                 215                 220                 
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu
225                 230                 235                 240 
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys
                245                 250                 255     
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg
            260                 265                 270         
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe
        275                 280                 285             
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys
    290                 295                 300                 
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg
305                 310                 315                 320 
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu
                325                 330                 335     
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala
            340                 345                 350         
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
        355                 360                 365             
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr
    370                 375                 380                 
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln
385                 390                 395                 400 
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe
                405                 410                 415     
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
            420                 425                 430         
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
        435                 440                 445             
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
    450                 455                 460                 
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
465                 470                 475                 480 
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His
                485                 490                 495     
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser
            500                 505                 510         
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile
        515                 520                 525             
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys
    530                 535                 540                 
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr
545                 550                 555                 560 
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr
                565                 570                 575     
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser
            580                 585                 590         
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu
        595                 600                 605             
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe
    610                 615                 620                 
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met
625                 630                 635                 640 
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro
                645                 650                 655     
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr
            660                 665                 670         
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro
        675                 680                 685             
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val
    690                 695                 700                 
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr
705                 710                 715                 720 
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly
                725                 730                 735     
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln
            740                 745                 750         
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser
        755                 760                 765             
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr
    770                 775                 780                 
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn
785                 790                 795                 800 
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile
                805                 810                 815     
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp
            820                 825                 830         
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val
        835                 840                 845             
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val
    850                 855                 860                 
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser
865                 870                 875                 880 
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr
                885                 890                 895     
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu
            900                 905                 910         
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met
        915                 920                 925             
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe
    930                 935                 940                 
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg
945                 950                 955                 960 
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe
                965                 970                 975     
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys
            980                 985                 990         
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile
        995                 1000                1005            
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val
    1010                1015                1020                
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln
1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln
                1045                1050                1055    
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala
            1060                1065                1070        
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu
        1075                1080                1085            
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln
    1090                1095                1100                
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val
1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Ser Ser Ile Gln Gly Ala Leu Arg Arg
                1125                1130                1135    
Gln Pro Ser Ile Ala Ser Gln His His Asp Val Thr Asn Ile Ser Thr
            1140                1145                1150        
Pro Thr His Ile Arg Val Val Asn Ala Phe Arg Ser Ser Leu Tyr Glu
        1155                1160                1165            
Gly Leu Glu Lys Pro Glu Ser Arg Ser Ser Ile His Asn Phe Met Thr
    1170                1175                1180                
His Pro Glu Phe Arg Ile Glu Asp Ser Glu Pro His Ile Pro Leu Ile
1185                1190                1195                1200
Asp Asp Thr Asp Ala Glu Asp Asp Ala Pro Thr Lys Arg Asn Ser Ser
                1205                1210                1215    
Pro Pro Pro Ser Pro Asn Lys Asn Asn Asn Ala Val Asp Ser Gly Ile
            1220                1225                1230        
His Leu Thr Ile Glu Met Asn Lys Ser Ala Thr Ser Ser Ser Pro Gly
        1235                1240                1245            
Ser Pro Leu His Ser Leu Glu Thr Ser Leu
    1250                1255            


<210> 6524
<211> 1159
<212> PRT
<213> Homo sapiens

<400> 6524
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Ala Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu
305                 310                 315                 320 
Lys Ser Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala
                325                 330                 335     
Asn Ala Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
            340                 345                 350         
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr
        355                 360                 365             
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu
    370                 375                 380                 
Gly Arg Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe
385                 390                 395                 400 
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
                405                 410                 415     
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
            420                 425                 430         
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
        435                 440                 445             
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
    450                 455                 460                 
Thr Thr Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His
465                 470                 475                 480 
Tyr Lys Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp
                485                 490                 495     
Leu Leu Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile
            500                 505                 510         
Leu Pro Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys
        515                 520                 525             
Thr Glu Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe
    530                 535                 540                 
Gln Pro Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr
545                 550                 555                 560 
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro
                565                 570                 575     
Asp Gly Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu
            580                 585                 590         
Lys Lys Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe
        595                 600                 605             
Arg Pro Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met
    610                 615                 620                 
Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr
625                 630                 635                 640 
Ala Gly Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp
                645                 650                 655     
Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu
            660                 665                 670         
Val Pro Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg
        675                 680                 685             
Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys
    690                 695                 700                 
Cys Gly Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys
705                 710                 715                 720 
Glu Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu
                725                 730                 735     
Arg Leu Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser
            740                 745                 750         
Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr
        755                 760                 765             
Gly Glu Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp
    770                 775                 780                 
Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala
785                 790                 795                 800 
Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp
                805                 810                 815     
Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr
            820                 825                 830         
Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val
        835                 840                 845             
Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro
    850                 855                 860                 
Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe
865                 870                 875                 880 
Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu
                885                 890                 895     
Arg Lys Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met
            900                 905                 910         
Lys Asn Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr
        915                 920                 925             
Leu Leu Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn
    930                 935                 940                 
Ala Pro Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn
945                 950                 955                 960 
Thr Phe Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile
                965                 970                 975     
His Gly Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe
            980                 985                 990         
Cys Thr Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln
        995                 1000                1005            
Phe Gly Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp
    1010                1015                1020                
Leu Trp Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val
1025                1030                1035                1040
Ile Ala Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly
                1045                1050                1055    
His Gly Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly
            1060                1065                1070        
Glu Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile
        1075                1080                1085            
Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Glu Val Val
    1090                1095                1100                
Ser Thr Phe Lys Arg Ser Gly Ser Val Gln Gly Ala Val Arg Arg Arg
1105                1110                1115                1120
Ser Ser Val Leu Ser Gln Leu His Asp Val Thr Asn Leu Ser Thr Pro
                1125                1130                1135    
Thr His Ala Ile Leu Ser Ala Ala Asn Pro Thr Ser Ala Ala Gly Asn
            1140                1145                1150        
Pro Gly Gly Glu Ser Val Pro
        1155                


<210> 6525
<211> 1249
<212> PRT
<213> Homo sapiens

<400> 6525
Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn
 1               5                  10                  15      
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys
        35                  40                  45              
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys
    50                  55                  60                  
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg
65                  70                  75                  80  
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln
        115                 120                 125             
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu
    130                 135                 140                 
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu
145                 150                 155                 160 
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser
                165                 170                 175     
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln
            180                 185                 190         
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala
        195                 200                 205             
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu
    210                 215                 220                 
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu
225                 230                 235                 240 
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys
                245                 250                 255     
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg
            260                 265                 270         
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe
        275                 280                 285             
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys
    290                 295                 300                 
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg
305                 310                 315                 320 
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu
                325                 330                 335     
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala
            340                 345                 350         
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
        355                 360                 365             
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr
    370                 375                 380                 
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln
385                 390                 395                 400 
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe
                405                 410                 415     
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
            420                 425                 430         
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
        435                 440                 445             
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
    450                 455                 460                 
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
465                 470                 475                 480 
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His
                485                 490                 495     
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser
            500                 505                 510         
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile
        515                 520                 525             
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys
    530                 535                 540                 
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr
545                 550                 555                 560 
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr
                565                 570                 575     
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser
            580                 585                 590         
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu
        595                 600                 605             
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe
    610                 615                 620                 
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met
625                 630                 635                 640 
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro
                645                 650                 655     
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr
            660                 665                 670         
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro
        675                 680                 685             
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val
    690                 695                 700                 
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr
705                 710                 715                 720 
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly
                725                 730                 735     
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln
            740                 745                 750         
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser
        755                 760                 765             
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr
    770                 775                 780                 
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn
785                 790                 795                 800 
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile
                805                 810                 815     
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp
            820                 825                 830         
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val
        835                 840                 845             
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val
    850                 855                 860                 
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser
865                 870                 875                 880 
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr
                885                 890                 895     
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu
            900                 905                 910         
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met
        915                 920                 925             
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe
    930                 935                 940                 
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg
945                 950                 955                 960 
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe
                965                 970                 975     
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys
            980                 985                 990         
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile
        995                 1000                1005            
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val
    1010                1015                1020                
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln
1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln
                1045                1050                1055    
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala
            1060                1065                1070        
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu
        1075                1080                1085            
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln
    1090                1095                1100                
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val
1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Ser Ser Ile Gln Gly Ala Leu Arg Arg
                1125                1130                1135    
Gln Pro Ser Ile Ala Ser Gln His His Asp Ile Arg Val Val Asn Ala
            1140                1145                1150        
Phe Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Arg Ser
        1155                1160                1165            
Ser Ile His Asn Phe Met Thr His Pro Glu Phe Arg Ile Glu Asp Ser
    1170                1175                1180                
Glu Pro His Ile Pro Leu Ile Asp Asp Thr Asp Ala Glu Asp Asp Ala
1185                1190                1195                1200
Pro Thr Lys Arg Asn Ser Ser Pro Pro Pro Ser Pro Asn Lys Asn Asn
                1205                1210                1215    
Asn Ala Val Asp Ser Gly Ile His Leu Thr Ile Glu Met Asn Lys Ser
            1220                1225                1230        
Ala Thr Ser Ser Ser Pro Gly Ser Pro Leu His Ser Leu Glu Thr Ser
        1235                1240                1245            
Leu
    


<210> 6526
<211> 1184
<212> PRT
<213> Homo sapiens

<400> 6526
Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn
 1               5                  10                  15      
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys
        35                  40                  45              
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys
    50                  55                  60                  
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg
65                  70                  75                  80  
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln
        115                 120                 125             
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu
    130                 135                 140                 
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu
145                 150                 155                 160 
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser
                165                 170                 175     
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln
            180                 185                 190         
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala
        195                 200                 205             
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu
    210                 215                 220                 
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu
225                 230                 235                 240 
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys
                245                 250                 255     
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg
            260                 265                 270         
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe
        275                 280                 285             
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys
    290                 295                 300                 
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg
305                 310                 315                 320 
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu
                325                 330                 335     
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala
            340                 345                 350         
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
        355                 360                 365             
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr
    370                 375                 380                 
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln
385                 390                 395                 400 
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe
                405                 410                 415     
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
            420                 425                 430         
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
        435                 440                 445             
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
    450                 455                 460                 
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
465                 470                 475                 480 
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His
                485                 490                 495     
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser
            500                 505                 510         
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile
        515                 520                 525             
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys
    530                 535                 540                 
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr
545                 550                 555                 560 
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr
                565                 570                 575     
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser
            580                 585                 590         
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu
        595                 600                 605             
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe
    610                 615                 620                 
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met
625                 630                 635                 640 
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro
                645                 650                 655     
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr
            660                 665                 670         
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro
        675                 680                 685             
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val
    690                 695                 700                 
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr
705                 710                 715                 720 
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly
                725                 730                 735     
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln
            740                 745                 750         
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser
        755                 760                 765             
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr
    770                 775                 780                 
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn
785                 790                 795                 800 
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile
                805                 810                 815     
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp
            820                 825                 830         
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val
        835                 840                 845             
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val
    850                 855                 860                 
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser
865                 870                 875                 880 
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr
                885                 890                 895     
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu
            900                 905                 910         
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met
        915                 920                 925             
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe
    930                 935                 940                 
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg
945                 950                 955                 960 
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe
                965                 970                 975     
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys
            980                 985                 990         
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile
        995                 1000                1005            
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Leu Ile Ser Thr
    1010                1015                1020                
Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala Gly His Gly Thr
1025                1030                1035                1040
Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu Asp Val Glu Glu
                1045                1050                1055    
Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe
            1060                1065                1070        
Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Asn Ala Phe
        1075                1080                1085            
Arg Ser Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Arg Ser Ser
    1090                1095                1100                
Ile His Asn Phe Met Thr His Pro Glu Phe Arg Ile Glu Asp Ser Glu
1105                1110                1115                1120
Pro His Ile Pro Leu Ile Asp Asp Thr Asp Ala Glu Asp Asp Ala Pro
                1125                1130                1135    
Thr Lys Arg Asn Ser Ser Pro Pro Pro Ser Pro Asn Lys Asn Asn Asn
            1140                1145                1150        
Ala Val Asp Ser Gly Ile His Leu Thr Ile Glu Met Asn Lys Ser Ala
        1155                1160                1165            
Thr Ser Ser Ser Pro Gly Ser Pro Leu His Ser Leu Glu Thr Ser Leu
    1170                1175                1180                


<210> 6527
<211> 1171
<212> PRT
<213> Homo sapiens

<400> 6527
Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn
 1               5                  10                  15      
Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys
        35                  40                  45              
Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys
    50                  55                  60                  
Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg
65                  70                  75                  80  
Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln
        115                 120                 125             
Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu
    130                 135                 140                 
Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu
145                 150                 155                 160 
Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser
                165                 170                 175     
Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln
            180                 185                 190         
Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala
        195                 200                 205             
Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu
    210                 215                 220                 
Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu
225                 230                 235                 240 
Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys
                245                 250                 255     
Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg
            260                 265                 270         
Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe
        275                 280                 285             
Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys
    290                 295                 300                 
Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg
305                 310                 315                 320 
Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu
                325                 330                 335     
Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala
            340                 345                 350         
Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys
        355                 360                 365             
Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr
    370                 375                 380                 
Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln
385                 390                 395                 400 
Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe
                405                 410                 415     
Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro
            420                 425                 430         
Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys
        435                 440                 445             
Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu
    450                 455                 460                 
Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu
465                 470                 475                 480 
Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His
                485                 490                 495     
Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser
            500                 505                 510         
Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile
        515                 520                 525             
Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys
    530                 535                 540                 
Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr
545                 550                 555                 560 
Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr
                565                 570                 575     
Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser
            580                 585                 590         
Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu
        595                 600                 605             
Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe
    610                 615                 620                 
Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met
625                 630                 635                 640 
Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro
                645                 650                 655     
Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr
            660                 665                 670         
Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro
        675                 680                 685             
Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val
    690                 695                 700                 
Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr
705                 710                 715                 720 
Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly
                725                 730                 735     
Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln
            740                 745                 750         
Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser
        755                 760                 765             
Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr
    770                 775                 780                 
Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn
785                 790                 795                 800 
Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile
                805                 810                 815     
Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp
            820                 825                 830         
Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val
        835                 840                 845             
Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val
    850                 855                 860                 
Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser
865                 870                 875                 880 
Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr
                885                 890                 895     
Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu
            900                 905                 910         
Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met
        915                 920                 925             
Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe
    930                 935                 940                 
Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg
945                 950                 955                 960 
Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe
                965                 970                 975     
Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys
            980                 985                 990         
Ile His Gly Glu Arg Asn Val Phe Glu Gly Ile Phe Asn Asn Ala Ile
        995                 1000                1005            
Phe Cys Thr Ile Val Leu Gly Thr Phe Val Val Gln Ile Ile Ile Val
    1010                1015                1020                
Gln Phe Gly Gly Lys Pro Phe Ser Cys Ser Glu Leu Ser Ile Glu Gln
1025                1030                1035                1040
Trp Leu Trp Ser Ile Phe Leu Gly Met Gly Thr Leu Leu Trp Gly Gln
                1045                1050                1055    
Leu Ile Ser Thr Ile Pro Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala
            1060                1065                1070        
Gly His Gly Thr Gln Lys Glu Glu Ile Pro Glu Glu Glu Leu Ala Glu
        1075                1080                1085            
Asp Val Glu Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln
    1090                1095                1100                
Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Met Asp Val
1105                1110                1115                1120
Val Asn Ala Phe Gln Ser Gly Ser Ser Ile Gln Gly Ala Leu Arg Arg
                1125                1130                1135    
Gln Pro Ser Ile Ala Ser Gln His His Asp Val Thr Asn Ile Ser Thr
            1140                1145                1150        
Pro Thr His Val Val Phe Ser Ser Ser Thr Ala Ser Thr Thr Val Gly
        1155                1160                1165            
Phe Glu Trp
    1170    


<210> 6528
<211> 1229
<212> PRT
<213> Homo sapiens

<400> 6528
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Ala Lys Thr Gln
    290                 295                 300                 
Asp Gly Val Ala Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile
305                 310                 315                 320 
Asp Asn Glu Glu Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu
                325                 330                 335     
Lys Ser Val Leu Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly
            340                 345                 350         
Lys Ala Gly Leu Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu
        355                 360                 365             
Tyr Phe Val Ile Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro
    370                 375                 380                 
Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile
385                 390                 395                 400 
Gly Ile Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala
                405                 410                 415     
Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn
            420                 425                 430         
Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr
        435                 440                 445             
Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr
    450                 455                 460                 
Val Val Gln Ala Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser
465                 470                 475                 480 
Pro Asp Val Phe Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile
                485                 490                 495     
Ser Ile Asn Ser Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu
            500                 505                 510         
Gly Gly Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu
        515                 520                 525             
Gly Phe Val Thr Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu
    530                 535                 540                 
Val Pro Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg
545                 550                 555                 560 
Lys Ser Met Ser Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met
                565                 570                 575     
Tyr Ser Lys Gly Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile
            580                 585                 590         
Leu Asp Arg Lys Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp
        595                 600                 605             
Asp Met Val Arg Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg
    610                 615                 620                 
Thr Ile Cys Ile Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp
625                 630                 635                 640 
Asp Asn Glu Asn Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val
                645                 650                 655     
Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys
            660                 665                 670         
Cys Lys Gln Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile
        675                 680                 685             
Asn Thr Ala Arg Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly
    690                 695                 700                 
Asp Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg
705                 710                 715                 720 
Asn Glu Lys Gly Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro
                725                 730                 735     
Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu
            740                 745                 750         
Val Lys Gly Ile Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val
        755                 760                 765             
Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala
    770                 775                 780                 
Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu
785                 790                 795                 800 
Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys
                805                 810                 815     
Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu
            820                 825                 830         
Gln Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr
        835                 840                 845             
Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu
    850                 855                 860                 
Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr
865                 870                 875                 880 
Glu Pro Pro Thr Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn
                885                 890                 895     
Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala
            900                 905                 910         
Phe Tyr Gln Leu Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys
        915                 920                 925             
Phe Phe Asp Ile Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro
    930                 935                 940                 
Ser Gln His Tyr Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu
945                 950                 955                 960 
Phe Asn Glu Ile Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe
                965                 970                 975     
Ser Gly Ile Tyr Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr
            980                 985                 990         
Phe Ile Cys Gln Ile Phe Ile Val Glu Phe Gly Gly Lys Pro Phe Ser
        995                 1000                1005            
Cys Thr Ser Leu Ser Leu Ser Gln Trp Leu Trp Cys Leu Phe Ile Gly
    1010                1015                1020                
Ile Gly Glu Leu Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Thr Arg
1025                1030                1035                1040
Ser Leu Lys Phe Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu
                1045                1050                1055    
Ile Thr Lys Asp Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met
            1060                1065                1070        
Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile
        1075                1080                1085            
Gln Thr Gln Ile Asp Val Ile Asn Thr Phe Gln Thr Gly Ala Ser Phe
    1090                1095                1100                
Lys Gly Val Leu Arg Arg Gln Asn Met Gly Gln His Leu Asp Val Lys
1105                1110                1115                1120
Leu Val Pro Ser Ser Ser Tyr Ile Lys Val Val Lys Ala Phe His Ser
                1125                1130                1135    
Ser Leu His Glu Ser Ile Gln Lys Pro Tyr Asn Gln Lys Ser Ile His
            1140                1145                1150        
Ser Phe Met Thr His Pro Glu Phe Ala Ile Glu Glu Glu Leu Pro Arg
        1155                1160                1165            
Thr Pro Leu Leu Asp Glu Glu Glu Glu Glu Asn Pro Asp Lys Ala Ser
    1170                1175                1180                
Lys Phe Gly Thr Arg Val Leu Leu Leu Asp Gly Glu Val Thr Pro Tyr
1185                1190                1195                1200
Ala Asn Thr Asn Asn Asn Ala Val Asp Cys Asn Gln Val Gln Leu Pro
                1205                1210                1215    
Gln Ser Asp Ser Ser Leu Gln Ser Leu Glu Thr Ser Val
            1220                1225                


<210> 6529
<211> 1205
<212> PRT
<213> Homo sapiens

<400> 6529
Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu
 1               5                  10                  15      
Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu
            20                  25                  30          
Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr
        35                  40                  45              
Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu
    50                  55                  60                  
Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe
65                  70                  75                  80  
Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu
                85                  90                  95      
Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala
            100                 105                 110         
Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu
        115                 120                 125             
Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu
    130                 135                 140                 
Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile
145                 150                 155                 160 
Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln
                165                 170                 175     
Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile
            180                 185                 190         
Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val
        195                 200                 205             
Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly
    210                 215                 220                 
Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr
225                 230                 235                 240 
Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu
                245                 250                 255     
Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr
            260                 265                 270         
Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly
        275                 280                 285             
Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln
    290                 295                 300                 
Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Thr Gln Asp Gly Val Ala
305                 310                 315                 320 
Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu
                325                 330                 335     
Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu
            340                 345                 350         
Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu
        355                 360                 365             
Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu Tyr Phe Val Ile
    370                 375                 380                 
Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Thr Pro
385                 390                 395                 400 
Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Thr Val
                405                 410                 415     
Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr Ile Ser
            420                 425                 430         
Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg
        435                 440                 445             
His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile Cys Ser
    450                 455                 460                 
Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr Val Val Gln Ala
465                 470                 475                 480 
Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe
                485                 490                 495     
Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser
            500                 505                 510         
Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro
        515                 520                 525             
Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu Gly Phe Val Thr
    530                 535                 540                 
Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu
545                 550                 555                 560 
Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser Met Ser
                565                 570                 575     
Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly
            580                 585                 590         
Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys
        595                 600                 605             
Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg
    610                 615                 620                 
Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile
625                 630                 635                 640 
Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp Asp Asn Glu Asn
                645                 650                 655     
Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp
            660                 665                 670         
Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala
        675                 680                 685             
Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg
    690                 695                 700                 
Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly Asp Asp Phe Leu
705                 710                 715                 720 
Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly
                725                 730                 735     
Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val
            740                 745                 750         
Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile
        755                 760                 765             
Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val Ala Val Thr Gly
    770                 775                 780                 
Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe
785                 790                 795                 800 
Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile
                805                 810                 815     
Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp
            820                 825                 830         
Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu
        835                 840                 845             
Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile
    850                 855                 860                 
Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu
865                 870                 875                 880 
Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr
                885                 890                 895     
Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile
            900                 905                 910         
Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu
        915                 920                 925             
Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile
    930                 935                 940                 
Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr
945                 950                 955                 960 
Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile
                965                 970                 975     
Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr
            980                 985                 990         
Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr Phe Ile Cys Gln
        995                 1000                1005            
Ile Phe Ile Val Glu Phe Gly Gly Lys Pro Phe Ser Cys Thr Ser Leu
    1010                1015                1020                
Ser Leu Ser Gln Trp Leu Trp Cys Leu Phe Ile Gly Ile Gly Glu Leu
1025                1030                1035                1040
Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Thr Arg Ser Leu Lys Phe
                1045                1050                1055    
Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu Ile Thr Lys Asp
            1060                1065                1070        
Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met Glu Leu Arg Arg
        1075                1080                1085            
Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile
    1090                1095                1100                
Lys Val Val Lys Ala Phe His Ser Ser Leu His Glu Ser Ile Gln Lys
1105                1110                1115                1120
Pro Tyr Asn Gln Lys Ser Ile His Ser Phe Met Thr His Pro Glu Phe
                1125                1130                1135    
Ala Ile Glu Glu Glu Leu Pro Arg Thr Pro Leu Leu Asp Glu Glu Glu
            1140                1145                1150        
Glu Glu Asn Pro Asp Lys Ala Ser Lys Phe Gly Thr Arg Val Leu Leu
        1155                1160                1165            
Leu Asp Gly Glu Val Thr Pro Tyr Ala Asn Thr Asn Asn Asn Ala Val
    1170                1175                1180                
Asp Cys Asn Gln Val Gln Leu Pro Gln Ser Asp Ser Ser Leu Gln Ser
1185                1190                1195                1200
Leu Glu Thr Ser Val
                1205


<210> 6530
<211> 1129
<212> PRT
<213> Homo sapiens

<400> 6530
Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln
 1               5                  10                  15      
Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala
            20                  25                  30          
Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys
        35                  40                  45              
Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys
    50                  55                  60                  
Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys
65                  70                  75                  80  
Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys
                85                  90                  95      
Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile
            100                 105                 110         
Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala
        115                 120                 125             
Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala
    130                 135                 140                 
Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile
145                 150                 155                 160 
Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp
                165                 170                 175     
Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu
            180                 185                 190         
Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val
        195                 200                 205             
Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu
    210                 215                 220                 
Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp
225                 230                 235                 240 
Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp
                245                 250                 255     
Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly
            260                 265                 270         
Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile
        275                 280                 285             
Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys
    290                 295                 300                 
Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala
305                 310                 315                 320 
Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser
                325                 330                 335     
Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala
            340                 345                 350         
Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala
        355                 360                 365             
Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile
    370                 375                 380                 
Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg
385                 390                 395                 400 
Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys
                405                 410                 415     
Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly
            420                 425                 430         
Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met
        435                 440                 445             
Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met
    450                 455                 460                 
Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr
465                 470                 475                 480 
Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys
                485                 490                 495     
Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu
            500                 505                 510         
Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro
        515                 520                 525             
Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu
    530                 535                 540                 
Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro
545                 550                 555                 560 
Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe
                565                 570                 575     
Asn Ser Val Arg Lys Ser Met Ser Thr Val Val Arg Met Pro Asp Gly
            580                 585                 590         
Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys
        595                 600                 605             
Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro
    610                 615                 620                 
Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys
625                 630                 635                 640 
Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Tyr Ala Gly
                645                 650                 655     
Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr
            660                 665                 670         
Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro
        675                 680                 685             
Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val
    690                 695                 700                 
Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly
705                 710                 715                 720 
Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe
                725                 730                 735     
Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu
            740                 745                 750         
Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr
        755                 760                 765             
Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu
    770                 775                 780                 
Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro
785                 790                 795                 800 
Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr
                805                 810                 815     
Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe
            820                 825                 830         
Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser
        835                 840                 845             
Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val
    850                 855                 860                 
Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys
865                 870                 875                 880 
Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser
                885                 890                 895     
Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys
            900                 905                 910         
Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn
        915                 920                 925             
Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu
    930                 935                 940                 
Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro
945                 950                 955                 960 
Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe
                965                 970                 975     
Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly
            980                 985                 990         
Glu Arg Asn Val Phe Asp Gly Ile Phe Ser Asn Pro Ile Phe Cys Thr
        995                 1000                1005            
Ile Val Leu Gly Thr Phe Gly Ile Gln Ile Val Ile Val Gln Phe Gly
    1010                1015                1020                
Gly Lys Pro Phe Ser Cys Ser Pro Leu Ser Thr Glu Gln Trp Leu Trp
1025                1030                1035                1040
Cys Leu Phe Val Gly Val Gly Glu Leu Val Trp Gly Gln Val Ile Ala
                1045                1050                1055    
Thr Ile Pro Thr Ser Gln Leu Lys Cys Leu Lys Glu Ala Gly His Gly
            1060                1065                1070        
Pro Gly Lys Asp Glu Met Thr Asp Glu Glu Leu Ala Glu Gly Glu Glu
        1075                1080                1085            
Glu Ile Asp His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp
    1090                1095                1100                
Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Val Cys Trp Asp Gly Lys
1105                1110                1115                1120
Lys Met Leu Arg Thr Thr Glu Val Gly
                1125                


<210> 6531
<211> 261
<212> PRT
<213> Homo sapiens

<400> 6531
Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu
 1               5                  10                  15      
Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr
            20                  25                  30          
Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly
        35                  40                  45              
Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg
    50                  55                  60                  
Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg
65                  70                  75                  80  
Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val
                85                  90                  95      
Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser
            100                 105                 110         
Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser
        115                 120                 125             
Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val
    130                 135                 140                 
Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly
145                 150                 155                 160 
Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe
                165                 170                 175     
Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met
            180                 185                 190         
Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala
        195                 200                 205             
Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly
    210                 215                 220                 
Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile
225                 230                 235                 240 
Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser
                245                 250                 255     
Lys His Asp Tyr Val
            260     


<210> 6532
<211> 261
<212> PRT
<213> Homo sapiens

<400> 6532
Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile
 1               5                  10                  15      
Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr
            20                  25                  30          
Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly
        35                  40                  45              
Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg
    50                  55                  60                  
Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg
65                  70                  75                  80  
Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val
                85                  90                  95      
Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser
            100                 105                 110         
Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser
        115                 120                 125             
Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val
    130                 135                 140                 
Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly
145                 150                 155                 160 
Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe
                165                 170                 175     
Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met
            180                 185                 190         
Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala
        195                 200                 205             
Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly
    210                 215                 220                 
Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile
225                 230                 235                 240 
Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser
                245                 250                 255     
Lys His Asp Tyr Val
            260     


<210> 6533
<211> 310
<212> PRT
<213> Homo sapiens

<400> 6533
Met Val Lys Ala Gly Asn Glu Thr Gln Ile Ser Glu Phe Leu Leu Leu
 1               5                  10                  15      
Gly Phe Ser Glu Lys Gln Glu Leu Gln Pro Phe Leu Phe Gly Leu Phe
            20                  25                  30          
Leu Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu
        35                  40                  45              
Ala Ala Ile Ser Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu
    50                  55                  60                  
Ser Asn Leu Ser Phe Val Asp Ile Cys Phe Ala Ser Thr Met Val Pro
65                  70                  75                  80  
Lys Met Leu Val Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala
                85                  90                  95      
Gly Cys Ile Thr Gln Met Cys Phe Phe Val Leu Phe Ile Val Leu Asp
            100                 105                 110         
Ser Leu Leu Leu Thr Val Met Ala Tyr Asp Gln Phe Val Ala Ile Cys
        115                 120                 125             
His Pro Leu His Tyr Thr Val Ile Met Ser Pro Gln Leu Cys Gly Leu
    130                 135                 140                 
Leu Val Leu Val Ser Trp Ile Met Ser Val Leu Asn Ser Met Leu Gln
145                 150                 155                 160 
Ser Leu Val Thr Leu Gln Leu Ser Phe Cys Thr Asp Leu Glu Ile Pro
                165                 170                 175     
His Phe Phe Cys Glu Leu Asn Glu Met Ile His Leu Ala Cys Ser Asp
            180                 185                 190         
Thr Phe Val Asn Asn Met Val Met His Phe Ala Ala Val Leu Leu Asp
        195                 200                 205             
Gly Gly Pro Leu Val Gly Ile Leu Tyr Ser Tyr Cys Arg Ile Val Ser
    210                 215                 220                 
Ser Ile Arg Ala Ile Ser Ser Thr Gln Gly Lys Tyr Lys Ala Leu Ser
225                 230                 235                 240 
Thr Cys Ala Ser His Leu Ser Val Val Ser Ile Phe Tyr Gly Thr Gly
                245                 250                 255     
Leu Gly Val Tyr Leu Ser Ser Thr Met Thr Gln Asn Leu His Ser Thr
            260                 265                 270         
Ala Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro
        275                 280                 285             
Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Thr Gln
    290                 295                 300                 
Phe Phe Arg Gly Lys Gln
305                 310 


<210> 6534
<211> 314
<212> PRT
<213> Homo sapiens

<400> 6534
Met Pro Leu Thr Asn Glu Ser His Pro Glu Glu Phe Ile Leu Leu Gly
 1               5                  10                  15      
Phe Ala Asp Arg Pro Trp Leu Glu Leu Pro Leu Phe Thr Ser Leu Leu
            20                  25                  30          
Ile Met Tyr Pro Ile Ala Val Met Gly Asn Ile Thr Ile Ile Leu Met
        35                  40                  45              
Ser Arg Leu Asp Ser Arg Leu His Ser Pro Met Tyr Phe Phe Leu Thr
    50                  55                  60                  
Asn Leu Ser Phe Leu Asp Met Cys Tyr Thr Thr Ser Ile Val Pro Gln
65                  70                  75                  80  
Met Leu Phe Asn Leu Gly Ser Ser Lys Lys Thr Ile Ser Tyr Met Gly
                85                  90                  95      
Cys Ala Val Gln Leu Tyr Phe Phe His Ile Met Gly Gly Thr Glu Cys
            100                 105                 110         
Leu Leu Leu Ala Ile Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Arg
        115                 120                 125             
Pro Leu His Tyr Thr Leu Ile Met Asn Gln Arg Val Cys Ile Leu Ser
    130                 135                 140                 
Phe His Arg Val Ala Asn Trp Asn Asn Leu Cys Cys Leu Arg Gly His
145                 150                 155                 160 
Cys His Ile Thr Ile Ala Thr Val Cys Ser Asn Lys Leu Asp His Leu
                165                 170                 175     
Val Cys Glu Ile Pro Val Leu Ile Lys Ile Ala Cys Gly Glu Lys Gly
            180                 185                 190         
Ser Asn Glu Leu Thr Leu Ser Val Val Cys Ile Phe Met Leu Ala Val
        195                 200                 205             
Pro Leu Cys Leu Ile Leu Ala Ser Tyr Ala Ser Ile Gly Ser Ala Val
    210                 215                 220                 
Phe Lys Ile Lys Ser Ser Lys Gly Arg Lys Lys Ala Phe Gly Thr Cys
225                 230                 235                 240 
Ser Ser His Leu Ile Val Val Phe Leu Phe Tyr Gly Pro Ala Ile Ser
                245                 250                 255     
Met Tyr Leu Gln Pro Pro Ser Ser Ile Ser Arg Asp Gln Pro Lys Phe
            260                 265                 270         
Met Ala Leu Phe Tyr Gly Val Val Thr Pro Ser Leu Asn Pro Phe Ile
        275                 280                 285             
Tyr Thr Leu Arg Asn Lys Asn Val Lys Gly Ala Leu Arg Asn Leu Val
    290                 295                 300                 
Arg Ser Ile Ser Ala Leu Ser Asp Ser Gly
305                 310                 


<210> 6535
<211> 1393
<212> PRT
<213> Homo sapiens

<400> 6535
Met Phe Ser Trp Ile Ile Glu Glu Phe Asn Phe Pro Ile Arg Asn Pro
 1               5                  10                  15      
Ser Glu Thr Glu Gly Leu Asp Lys Glu Met Leu Lys Leu Val Phe Ile
            20                  25                  30          
Pro Ser Cys Phe Val Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro
        35                  40                  45              
Arg Ile Val Glu His Pro Ser Asp Val Ile Val Ser Lys Gly Glu Pro
    50                  55                  60                  
Thr Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu
65                  70                  75                  80  
Trp Tyr Lys Asp Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg
                85                  90                  95      
Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile
            100                 105                 110         
Val His Gly Arg Arg Ser Lys Pro Asp Glu Gly Ser Tyr Val Cys Val
        115                 120                 125             
Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser Arg Asn Ala Ser Leu Glu
    130                 135                 140                 
Val Ala Leu Leu Arg Asp Asp Phe Arg Gln Asn Pro Thr Asp Val Val
145                 150                 155                 160 
Val Ala Ala Gly Glu Pro Ala Ile Leu Glu Cys Gln Pro Pro Arg Gly
                165                 170                 175     
His Pro Glu Pro Thr Ile Tyr Trp Lys Lys Asp Lys Val Arg Ile Asp
            180                 185                 190         
Asp Lys Glu Glu Arg Ile Ser Ile Arg Gly Gly Lys Leu Met Ile Ser
        195                 200                 205             
Asn Thr Arg Lys Ser Asp Ala Gly Met Tyr Thr Cys Val Gly Thr Asn
    210                 215                 220                 
Met Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu
225                 230                 235                 240 
Arg Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu
                245                 250                 255     
Glu Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr
            260                 265                 270         
Val Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp
        275                 280                 285             
Ile Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp
    290                 295                 300                 
Glu Gly Thr Tyr Met Cys Ile Ala Glu Asn Arg Val Gly Lys Met Glu
305                 310                 315                 320 
Ala Ser Ala Thr Leu Thr Val Arg Ala Pro Pro Gln Phe Val Val Arg
                325                 330                 335     
Pro Arg Asp Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys
            340                 345                 350         
Glu Thr Lys Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly
        355                 360                 365             
Ser Gln Asn Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg
    370                 375                 380                 
Cys Ser Val Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg
385                 390                 395                 400 
Ser Asp Ala Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser
                405                 410                 415     
Ile Leu Ala Lys Ala Gln Leu Glu Val Thr Asp Val Leu Thr Asp Arg
            420                 425                 430         
Pro Pro Pro Ile Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Ala Val
        435                 440                 445             
Asp Gly Thr Ala Leu Leu Lys Cys Lys Ala Thr Gly Asp Pro Leu Pro
    450                 455                 460                 
Val Ile Ser Trp Leu Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro
465                 470                 475                 480 
Arg Ala Thr Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg
                485                 490                 495     
Ile Ser Asp Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser Gly
            500                 505                 510         
Glu Thr Ser Trp Ser Ala Val Leu Asp Val Thr Glu Ser Gly Ala Thr
        515                 520                 525             
Ile Ser Lys Asn Tyr Asp Leu Ser Asp Leu Pro Gly Pro Pro Ser Lys
    530                 535                 540                 
Pro Gln Val Thr Asp Val Thr Lys Asn Ser Val Thr Leu Ser Trp Gln
545                 550                 555                 560 
Pro Gly Thr Pro Gly Thr Leu Pro Ala Ser Ala Tyr Ile Ile Glu Ala
                565                 570                 575     
Phe Ser Gln Ser Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val
            580                 585                 590         
Lys Thr Thr Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr
        595                 600                 605             
Leu Phe Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser
    610                 615                 620                 
Pro Met Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln
625                 630                 635                 640 
Gly Val Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val
                645                 650                 655     
Arg Leu His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr
            660                 665                 670         
Trp Thr Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met
        675                 680                 685             
Tyr Arg Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu
    690                 695                 700                 
Asp Ala Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys
705                 710                 715                 720 
Lys Gly Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe
                725                 730                 735     
Gln Gly Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala
            740                 745                 750         
Pro Ser Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr
        755                 760                 765             
Asn Ser Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His
    770                 775                 780                 
Gln Asn Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu
785                 790                 795                 800 
Thr Arg Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val
                805                 810                 815     
Ile Ile Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala
            820                 825                 830         
Ala Ser Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile
        835                 840                 845             
Ile Ile Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser
    850                 855                 860                 
Ile Thr Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala
865                 870                 875                 880 
Gly Ile Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp
                885                 890                 895     
Leu Tyr Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val
            900                 905                 910         
Thr Phe Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro
        915                 920                 925             
Gly Leu Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser
    930                 935                 940                 
Trp Pro Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn
945                 950                 955                 960 
Glu Ile Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly
                965                 970                 975     
Gln Gly Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser
            980                 985                 990         
Ser Ile Asp Phe Thr Thr Lys Thr Ser Tyr Asn Ser Ser Ser Gln Ile
        995                 1000                1005            
Thr Gln Ala Thr Pro Tyr Ala Thr Thr Gln Ile Leu His Ser Asn Ser
    1010                1015                1020                
Ile His Glu Leu Ala Val Asp Leu Pro Asp Pro Gln Trp Lys Ser Ser
1025                1030                1035                1040
Ile Gln Gln Lys Thr Asp Leu Met Gly Phe Gly Tyr Ser Leu Pro Asp
                1045                1050                1055    
Gln Asn Lys Gly Asn Asn Gly Gly Lys Gly Gly Lys Lys Lys Lys Asn
            1060                1065                1070        
Lys Asn Ser Ser Lys Pro Gln Lys Asn Asn Gly Ser Thr Trp Ala Asn
        1075                1080                1085            
Val Pro Leu Pro Pro Pro Pro Val Gln Pro Leu Pro Gly Thr Glu Leu
    1090                1095                1100                
Glu His Tyr Ala Val Glu Gln Gln Glu Asn Gly Tyr Asp Ser Asp Ser
1105                1110                1115                1120
Trp Cys Pro Pro Leu Pro Val Gln Thr Tyr Leu His Gln Gly Leu Glu
                1125                1130                1135    
Asp Glu Leu Glu Glu Asp Asp Asp Arg Val Pro Thr Pro Pro Val Arg
            1140                1145                1150        
Gly Val Ala Ser Ser Pro Ala Ile Ser Phe Gly Gln Gln Ser Thr Ala
        1155                1160                1165            
Thr Leu Thr Pro Ser Pro Arg Glu Glu Met Gln Pro Met Leu Gln Ala
    1170                1175                1180                
His Leu Asp Glu Leu Thr Arg Ala Tyr Gln Phe Asp Ile Ala Lys Gln
1185                1190                1195                1200
Thr Trp His Ile Gln Ser Asn Asn Gln Pro Pro Gln Pro Pro Val Pro
                1205                1210                1215    
Pro Leu Gly Tyr Val Ser Gly Ala Leu Ile Ser Asp Leu Glu Thr Asp
            1220                1225                1230        
Val Ala Asp Asp Asp Ala Asp Asp Glu Glu Glu Ala Leu Glu Ile Pro
        1235                1240                1245            
Arg Pro Leu Arg Ala Leu Asp Gln Thr Pro Gly Ser Ser Met Asp Asn
    1250                1255                1260                
Leu Asp Ser Ser Val Thr Gly Lys Ala Phe Thr Ser Ser Gln Arg Pro
1265                1270                1275                1280
Arg Pro Thr Ser Pro Phe Ser Thr Asp Ser Asn Thr Ser Ala Ala Leu
                1285                1290                1295    
Ser Gln Ser Gln Arg Pro Arg Pro Thr Lys Lys His Lys Gly Gly Arg
            1300                1305                1310        
Met Asp Gln Gln Pro Ala Leu Pro His Arg Arg Glu Gly Met Thr Asp
        1315                1320                1325            
Glu Glu Ala Leu Val Pro Tyr Ser Lys Pro Ser Phe Pro Ser Pro Gly
    1330                1335                1340                
Gly His Ser Ser Ser Gly Thr Ala Ser Ser Lys Gly Ser Thr Gly Pro
1345                1350                1355                1360
Arg Lys Thr Glu Val Leu Arg Ala Gly His Gln Arg Asn Ala Ser Asp
                1365                1370                1375    
Leu Leu Asp Ile Gly Tyr Met Gly Ser Asn Ser Gln Gly Gln Phe Thr
            1380                1385                1390        
Glu
    


<210> 6536
<211> 507
<212> PRT
<213> Homo sapiens

<400> 6536
Glu Val Trp Asp Cys Pro Gly Asn Ser Arg Val Ser Gly Pro Arg Pro
 1               5                  10                  15      
Ile Leu Gly Ala Met Gly Val Ile Gly Ile Gln Leu Val Val Thr Met
            20                  25                  30          
Val Met Ala Ser Val Met Gln Lys Ile Ile Pro His Tyr Ser Leu Ala
        35                  40                  45              
Arg Trp Leu Leu Cys Asn Gly Ser Leu Arg Trp Tyr Gln His Pro Thr
    50                  55                  60                  
Glu Glu Glu Leu Arg Ile Leu Ala Gly Lys Gln Gln Lys Gly Lys Thr
65                  70                  75                  80  
Lys Lys Asp Arg Lys Tyr Asn Gly His Ile Glu Ser Lys Pro Leu Thr
                85                  90                  95      
Ile Pro Lys Asp Ile Asp Leu His Leu Glu Thr Lys Ser Val Thr Glu
            100                 105                 110         
Val Asp Thr Leu Ala Leu His Tyr Phe Pro Glu Tyr Gln Trp Leu Val
        115                 120                 125             
Asp Phe Thr Val Ala Ala Thr Val Val Tyr Leu Val Thr Glu Val Tyr
    130                 135                 140                 
Tyr Asn Phe Met Lys Pro Thr Gln Glu Met Asn Ile Ser Leu Val Trp
145                 150                 155                 160 
Cys Leu Leu Val Leu Ser Phe Ala Ile Lys Val Leu Phe Ser Leu Thr
                165                 170                 175     
Thr His Tyr Phe Lys Val Glu Asp Gly Gly Glu Arg Ser Val Cys Val
            180                 185                 190         
Thr Phe Gly Phe Phe Phe Phe Val Lys Ala Met Ala Val Leu Ile Val
        195                 200                 205             
Thr Glu Asn Tyr Leu Glu Phe Gly Leu Glu Thr Gly Phe Thr Asn Phe
    210                 215                 220                 
Ser Asp Ser Ala Met Gln Phe Leu Glu Lys Gln Gly Leu Glu Ser Gln
225                 230                 235                 240 
Ser Pro Val Ser Lys Leu Thr Phe Lys Phe Phe Leu Ala Ile Phe Cys
                245                 250                 255     
Ser Phe Ile Gly Ala Phe Leu Thr Phe Pro Gly Leu Arg Leu Ala Gln
            260                 265                 270         
Met His Leu Asp Ala Leu Asn Leu Ala Thr Glu Lys Ile Thr Gln Thr
        275                 280                 285             
Leu Leu His Ile Asn Phe Leu Ala Pro Leu Phe Met Val Leu Leu Trp
    290                 295                 300                 
Val Lys Pro Ile Thr Lys Asp Tyr Ile Met Asn Pro Pro Leu Gly Lys
305                 310                 315                 320 
Glu Ser Ile Pro Leu Met Thr Glu Ala Thr Phe Asp Thr Leu Arg Leu
                325                 330                 335     
Trp Leu Ile Ile Leu Leu Cys Ala Leu Arg Leu Ala Met Met Arg Ser
            340                 345                 350         
His Leu Gln Ala Tyr Leu Asn Leu Ala Gln Lys Cys Val Asp Gln Met
        355                 360                 365             
Lys Lys Glu Ala Gly Arg Ile Ser Thr Val Glu Leu Gln Lys Met Val
    370                 375                 380                 
Ala Arg Val Phe Tyr Tyr Leu Cys Val Ile Ala Leu Gln Tyr Val Ala
385                 390                 395                 400 
Pro Leu Val Met Leu Leu His Thr Thr Leu Leu Leu Lys Thr Leu Gly
                405                 410                 415     
Asn His Ser Trp Gly Ile Tyr Pro Glu Ser Ile Ser Thr Leu Pro Val
            420                 425                 430         
Asp Asn Ser Leu Leu Ser Asn Ser Val Tyr Ser Glu Leu Pro Ser Ala
        435                 440                 445             
Glu Gly Lys Met Lys Val Thr Val Thr Gln Ile Thr Val Ala Leu Ser
    450                 455                 460                 
Ser Leu Lys Asn Ile Phe Thr Pro Leu Leu Phe Arg Gly Leu Leu Ser
465                 470                 475                 480 
Phe Leu Thr Trp Trp Ile Ala Ala Cys Leu Phe Ser Thr Ser Leu Phe
                485                 490                 495     
Gly Leu Phe Tyr His Gln Tyr Leu Thr Val Ala
            500                 505         


<210> 6537
<211> 3859
<212> PRT
<213> Homo sapiens

<400> 6537
Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr
 1               5                  10                  15      
Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn
            20                  25                  30          
Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn
        35                  40                  45              
Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His
    50                  55                  60                  
Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe
65                  70                  75                  80  
Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile
                85                  90                  95      
Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn
            100                 105                 110         
Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn
        115                 120                 125             
Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg
    130                 135                 140                 
Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln
145                 150                 155                 160 
Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro
                165                 170                 175     
Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met
            180                 185                 190         
Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu
        195                 200                 205             
Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val
    210                 215                 220                 
Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys
225                 230                 235                 240 
Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn
                245                 250                 255     
Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr
            260                 265                 270         
Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu
        275                 280                 285             
Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys
    290                 295                 300                 
Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys
305                 310                 315                 320 
Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys
                325                 330                 335     
His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp
            340                 345                 350         
Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg
        355                 360                 365             
Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His
    370                 375                 380                 
His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln
385                 390                 395                 400 
Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln
                405                 410                 415     
Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser
            420                 425                 430         
Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met
        435                 440                 445             
Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu
    450                 455                 460                 
Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val
465                 470                 475                 480 
Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro
                485                 490                 495     
Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro
            500                 505                 510         
Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu
        515                 520                 525             
Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr
    530                 535                 540                 
Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile
545                 550                 555                 560 
Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile
                565                 570                 575     
Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu
            580                 585                 590         
Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala
        595                 600                 605             
Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg
    610                 615                 620                 
Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr
625                 630                 635                 640 
Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro
                645                 650                 655     
Tyr Met Val Asp Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala
            660                 665                 670         
Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile
        675                 680                 685             
Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val
    690                 695                 700                 
Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser
705                 710                 715                 720 
Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu
                725                 730                 735     
His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu
            740                 745                 750         
Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly
        755                 760                 765             
Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro
    770                 775                 780                 
Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln
785                 790                 795                 800 
His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg
                805                 810                 815     
Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val
            820                 825                 830         
Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr
        835                 840                 845             
Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His
    850                 855                 860                 
Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu
865                 870                 875                 880 
Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly
                885                 890                 895     
Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu
            900                 905                 910         
His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe
        915                 920                 925             
Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu
    930                 935                 940                 
Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg
945                 950                 955                 960 
Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser
                965                 970                 975     
Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn
            980                 985                 990         
Phe Thr Glu Lys Thr Ile Pro Asn Val Ile Ile Ser His Arg Tyr Lys
        995                 1000                1005            
Ala Gln Asp Thr Pro Ala Arg Lys Thr Phe Glu Gln Ala Leu Thr Gly
    1010                1015                1020                
Ala Phe Met Ser Ala Val Ile Lys Asp Leu Arg Pro Ser Ala Leu Pro
1025                1030                1035                1040
Phe Val Ala Ser Leu Ile Arg His Tyr Thr Met Val Ala Val Ala Gln
                1045                1050                1055    
Gln Cys Gly Pro Phe Leu Leu Pro Cys Tyr Gln Val Gly Ser Gln Pro
            1060                1065                1070        
Ser Thr Ala Met Phe His Ser Glu Glu Asn Gly Ser Lys Gly Met Asp
        1075                1080                1085            
Pro Leu Val Leu Ile Asp Ala Ile Ala Ile Cys Met Ala Tyr Glu Glu
    1090                1095                1100                
Lys Glu Leu Cys Lys Ile Gly Glu Val Ala Leu Ala Val Ile Phe Asp
1105                1110                1115                1120
Val Ala Ser Ile Ile Leu Gly Ser Lys Glu Arg Ala Cys Gln Leu Pro
                1125                1130                1135    
Leu Phe Ser Tyr Ile Val Glu Arg Leu Cys Ala Cys Cys Tyr Glu Gln
            1140                1145                1150        
Ala Trp Tyr Ala Lys Leu Gly Gly Val Val Ser Ile Lys Phe Leu Met
        1155                1160                1165            
Glu Arg Leu Pro Leu Thr Trp Val Leu Gln Asn Gln Gln Thr Phe Leu
    1170                1175                1180                
Lys Ala Leu Leu Phe Val Met Met Asp Leu Thr Gly Glu Val Ser Asn
1185                1190                1195                1200
Gly Ala Val Ala Met Ala Lys Thr Thr Leu Glu Gln Leu Leu Met Arg
                1205                1210                1215    
Cys Ala Thr Pro Leu Lys Asp Glu Glu Arg Ala Glu Glu Ile Val Ala
            1220                1225                1230        
Ala Gln Glu Lys Ser Phe His His Val Thr His Asp Leu Val Arg Glu
        1235                1240                1245            
Val Thr Ser Pro Asn Ser Thr Val Arg Lys Gln Ala Met His Ser Leu
    1250                1255                1260                
Gln Val Leu Ala Gln Val Thr Gly Lys Ser Val Thr Val Ile Met Glu
1265                1270                1275                1280
Pro His Lys Glu Val Leu Gln Asp Met Val Pro Pro Lys Lys His Leu
                1285                1290                1295    
Leu Arg His Gln Pro Ala Asn Ala Gln Ile Gly Leu Met Glu Gly Asn
            1300                1305                1310        
Thr Phe Cys Thr Thr Leu Gln Pro Arg Leu Phe Thr Met Asp Leu Asn
        1315                1320                1325            
Val Val Glu His Lys Val Phe Tyr Thr Glu Leu Leu Asn Leu Cys Glu
    1330                1335                1340                
Ala Glu Asp Ser Ala Leu Thr Lys Leu Pro Cys Tyr Lys Ser Leu Pro
1345                1350                1355                1360
Ser Leu Val Pro Leu Arg Ile Ala Ala Leu Asn Ala Leu Ala Ala Cys
                1365                1370                1375    
Asn Tyr Leu Pro Gln Ser Arg Glu Lys Ile Ile Ala Ala Leu Phe Lys
            1380                1385                1390        
Ala Leu Asn Ser Thr Asn Ser Glu Leu Gln Glu Ala Gly Glu Ala Cys
        1395                1400                1405            
Met Arg Lys Phe Leu Glu Gly Ala Thr Ile Glu Val Asp Gln Ile His
    1410                1415                1420                
Thr His Met Arg Pro Leu Leu Met Met Leu Gly Asp Tyr Arg Ser Leu
1425                1430                1435                1440
Thr Leu Asn Val Val Asn Arg Leu Thr Ser Val Thr Arg Leu Phe Pro
                1445                1450                1455    
Asn Ser Phe Asn Asp Lys Phe Cys Asp Gln Met Met Gln His Leu Arg
            1460                1465                1470        
Lys Trp Met Glu Val Val Val Ile Thr His Lys Gly Gly Gln Arg Ser
        1475                1480                1485            
Asp Gly Asn Glu Ser Ile Ser Glu Cys Gly Arg Cys Pro Leu Ser Pro
    1490                1495                1500                
Phe Cys Gln Phe Glu Glu Met Lys Ile Cys Ser Ala Ile Ile Asn Leu
1505                1510                1515                1520
Phe His Leu Ile Pro Ala Ala Pro Gln Thr Leu Val Lys Pro Leu Leu
                1525                1530                1535    
Glu Val Val Met Lys Thr Glu Arg Ala Met Leu Ile Glu Ala Gly Ser
            1540                1545                1550        
Pro Phe Arg Glu Pro Leu Ile Lys Phe Leu Thr Arg His Pro Ser Gln
        1555                1560                1565            
Thr Val Glu Leu Phe Met Met Glu Ala Thr Leu Asn Asp Pro Gln Trp
    1570                1575                1580                
Ser Arg Met Phe Met Ser Phe Leu Lys His Lys Asp Ala Arg Pro Leu
1585                1590                1595                1600
Arg Asp Val Leu Ala Ala Asn Pro Asn Arg Phe Ile Thr Leu Leu Leu
                1605                1610                1615    
Pro Gly Gly Ala Gln Thr Ala Val Arg Pro Gly Ser Pro Ser Thr Ser
            1620                1625                1630        
Thr Met Arg Leu Asp Leu Gln Phe Gln Ala Ile Lys Ile Ile Ser Ile
        1635                1640                1645            
Ile Val Lys Asn Asp Asp Ser Trp Leu Ala Ser Gln His Ser Leu Val
    1650                1655                1660                
Ser Gln Leu Arg Arg Val Trp Val Ser Glu Asn Phe Gln Glu Arg His
1665                1670                1675                1680
Arg Lys Glu Asn Met Ala Ala Thr Asn Trp Lys Glu Pro Lys Leu Leu
                1685                1690                1695    
Ala Tyr Cys Leu Leu Asn Tyr Cys Lys Arg Asn Tyr Gly Asp Ile Glu
            1700                1705                1710        
Leu Leu Phe Gln Leu Leu Arg Ala Phe Thr Gly Arg Phe Leu Cys Asn
        1715                1720                1725            
Met Thr Phe Leu Lys Glu Tyr Met Glu Glu Glu Ile Pro Lys Asn Tyr
    1730                1735                1740                
Ser Ile Ala Gln Lys Arg Ala Leu Phe Phe Arg Phe Val Asp Phe Asn
1745                1750                1755                1760
Asp Pro Asn Phe Gly Asp Glu Leu Lys Ala Lys Val Leu Gln His Ile
                1765                1770                1775    
Leu Asn Pro Ala Phe Leu Tyr Ser Phe Glu Lys Gly Glu Gly Glu Gln
            1780                1785                1790        
Leu Leu Gly Pro Pro Asn Pro Glu Gly Asp Asn Pro Glu Ser Ile Thr
        1795                1800                1805            
Ser Val Phe Ile Thr Lys Val Leu Asp Pro Glu Lys Gln Ala Asp Met
    1810                1815                1820                
Leu Asp Ser Leu Arg Ile Tyr Leu Leu Gln Tyr Ala Thr Leu Leu Val
1825                1830                1835                1840
Glu His Ala Pro His His Ile His Asp Asn Asn Lys Asn Arg Asn Ser
                1845                1850                1855    
Lys Leu Arg Arg Leu Met Thr Phe Ala Trp Pro Cys Leu Leu Ser Lys
            1860                1865                1870        
Ala Cys Val Asp Pro Ala Cys Lys Tyr Ser Gly His Leu Leu Leu Ala
        1875                1880                1885            
His Ile Ile Ala Lys Phe Ala Ile His Lys Lys Ile Val Leu Gln Val
    1890                1895                1900                
Phe His Ser Leu Leu Lys Ala His Ala Met Glu Ala Arg Ala Ile Val
1905                1910                1915                1920
Arg Gln Ala Met Ala Ile Leu Thr Pro Ala Val Pro Ala Arg Met Glu
                1925                1930                1935    
Asp Gly His Gln Met Leu Thr His Trp Thr Arg Lys Ile Ile Val Glu
            1940                1945                1950        
Glu Gly His Thr Val Pro Gln Leu Val His Ile Leu His Leu Ile Val
        1955                1960                1965            
Gln His Phe Lys Val Tyr Tyr Pro Val Arg His His Leu Val Gln His
    1970                1975                1980                
Met Val Ser Ala Met Gln Arg Leu Gly Phe Thr Pro Ser Val Thr Ile
1985                1990                1995                2000
Glu Gln Arg Arg Leu Ala Val Asp Leu Ser Glu Val Val Ile Lys Trp
                2005                2010                2015    
Glu Leu Gln Arg Ile Lys Asp Gln Gln Pro Asp Ser Asp Met Asp Pro
            2020                2025                2030        
Asn Ser Ser Gly Glu Gly Val Asn Ser Val Ser Ser Ser Ile Lys Arg
        2035                2040                2045            
Gly Leu Ser Val Asp Ser Ala Gln Glu Val Lys Arg Phe Arg Thr Ala
    2050                2055                2060                
Thr Gly Ala Ile Ser Ala Val Phe Gly Arg Ser Gln Ser Leu Pro Gly
2065                2070                2075                2080
Ala Asp Ser Leu Leu Ala Lys Pro Ile Asp Lys Gln His Thr Asp Thr
                2085                2090                2095    
Val Val Asn Phe Leu Ile Arg Val Ala Cys Gln Val Asn Asp Asn Thr
            2100                2105                2110        
Asn Thr Ala Gly Ser Pro Gly Glu Val Leu Ser Arg Arg Cys Val Asn
        2115                2120                2125            
Leu Leu Lys Thr Ala Leu Arg Pro Asp Met Trp Pro Lys Ser Glu Leu
    2130                2135                2140                
Lys Leu Gln Trp Phe Asp Lys Leu Leu Met Thr Val Glu Gln Pro Asn
2145                2150                2155                2160
Gln Val Asn Tyr Gly Asn Ile Cys Thr Gly Leu Glu Val Leu Ser Phe
                2165                2170                2175    
Leu Leu Thr Val Leu Gln Ser Pro Ala Ile Leu Ser Ser Phe Lys Pro
            2180                2185                2190        
Leu Gln Arg Gly Ile Ala Ala Cys Met Thr Cys Gly Asn Thr Lys Val
        2195                2200                2205            
Leu Arg Ala Val His Ser Leu Leu Ser Arg Leu Met Ser Ile Phe Pro
    2210                2215                2220                
Thr Glu Pro Ser Thr Ser Ser Val Ala Ser Lys Tyr Glu Glu Leu Glu
2225                2230                2235                2240
Cys Leu Tyr Ala Ala Val Gly Lys Val Ile Tyr Glu Gly Leu Thr Asn
                2245                2250                2255    
Tyr Glu Lys Ala Thr Asn Ala Asn Pro Ser Gln Leu Phe Gly Thr Leu
            2260                2265                2270        
Met Ile Leu Lys Ser Ala Cys Ser Asn Asn Pro Ser Tyr Ile Asp Arg
        2275                2280                2285            
Leu Ile Ser Val Phe Met Arg Ser Leu Gln Lys Met Val Arg Glu His
    2290                2295                2300                
Leu Asn Pro Gln Ala Ala Ser Gly Ser Thr Glu Ala Thr Ser Gly Thr
2305                2310                2315                2320
Ser Glu Leu Val Met Leu Ser Leu Glu Leu Val Lys Thr Arg Leu Ala
                2325                2330                2335    
Val Met Ser Met Glu Met Arg Lys Asn Phe Ile Gln Ala Ile Leu Thr
            2340                2345                2350        
Ser Leu Ile Glu Lys Ser Pro Asp Ala Lys Ile Leu Arg Ala Val Val
        2355                2360                2365            
Lys Ile Val Glu Glu Trp Val Lys Asn Asn Ser Pro Met Ala Ala Asn
    2370                2375                2380                
Gln Thr Pro Thr Leu Arg Glu Lys Ser Ile Leu Leu Val Lys Met Met
2385                2390                2395                2400
Thr Tyr Ile Glu Lys Arg Phe Pro Glu Asp Leu Glu Leu Asn Ala Gln
                2405                2410                2415    
Phe Leu Asp Leu Val Asn Tyr Val Tyr Arg Asp Glu Thr Leu Ser Gly
            2420                2425                2430        
Ser Glu Leu Thr Ala Lys Leu Glu Pro Ala Phe Leu Ser Gly Leu Arg
        2435                2440                2445            
Cys Ala Gln Pro Leu Ile Arg Ala Lys Phe Phe Glu Val Phe Asp Asn
    2450                2455                2460                
Ser Met Lys Arg Arg Val Tyr Glu Arg Leu Leu Tyr Val Thr Cys Ser
2465                2470                2475                2480
Gln Asn Trp Glu Ala Met Gly Asn His Phe Trp Ile Lys Gln Cys Ile
                2485                2490                2495    
Glu Leu Leu Leu Ala Val Cys Glu Lys Ser Thr Pro Ile Gly Thr Ser
            2500                2505                2510        
Cys Gln Gly Ala Met Leu Pro Ser Ile Thr Asn Val Ile Asn Leu Ala
        2515                2520                2525            
Asp Ser His Asp Arg Ala Ala Phe Ala Met Val Thr His Val Lys Gln
    2530                2535                2540                
Glu Pro Arg Glu Arg Glu Asn Ser Glu Ser Lys Glu Glu Asp Val Glu
2545                2550                2555                2560
Ile Asp Ile Glu Leu Ala Pro Gly Asp Gln Thr Ser Thr Pro Lys Thr
                2565                2570                2575    
Lys Glu Leu Ser Glu Lys Asp Ile Gly Asn Gln Leu His Met Leu Thr
            2580                2585                2590        
Asn Arg His Asp Lys Phe Leu Asp Thr Leu Arg Glu Val Lys Thr Gly
        2595                2600                2605            
Ala Leu Leu Ser Ala Phe Val Gln Leu Cys His Ile Ser Thr Thr Leu
    2610                2615                2620                
Ala Glu Lys Thr Trp Val Gln Leu Phe Pro Arg Leu Trp Lys Ile Leu
2625                2630                2635                2640
Ser Asp Arg Gln Gln His Ala Leu Ala Gly Glu Ile Ser Pro Phe Leu
                2645                2650                2655    
Cys Ser Gly Ser His Gln Val Gln Arg Asp Cys Gln Pro Ser Ala Leu
            2660                2665                2670        
Asn Cys Phe Val Glu Ala Met Ser Gln Cys Val Pro Pro Ile Pro Ile
        2675                2680                2685            
Arg Pro Cys Val Leu Lys Tyr Leu Gly Lys Thr His Asn Leu Trp Phe
    2690                2695                2700                
Arg Ser Thr Leu Met Leu Glu His Gln Ala Phe Glu Lys Gly Leu Ser
2705                2710                2715                2720
Leu Gln Ile Lys Pro Lys Gln Thr Thr Glu Phe Tyr Glu Gln Glu Ser
                2725                2730                2735    
Ile Thr Pro Pro Gln Gln Glu Ile Leu Asp Ser Leu Ala Glu Leu Tyr
            2740                2745                2750        
Ser Leu Leu Gln Glu Glu Asp Met Trp Ala Gly Leu Trp Gln Lys Arg
        2755                2760                2765            
Cys Lys Tyr Ser Glu Thr Ala Thr Ala Ile Ala Tyr Glu Gln His Gly
    2770                2775                2780                
Phe Phe Glu Gln Ala Gln Glu Ser Tyr Glu Lys Ala Met Asp Lys Ala
2785                2790                2795                2800
Lys Lys Glu His Glu Arg Ser Asn Ala Ser Pro Ala Ile Phe Pro Glu
                2805                2810                2815    
Tyr Gln Leu Trp Glu Asp His Trp Ile Arg Cys Ser Lys Glu Leu Asn
            2820                2825                2830        
Gln Trp Glu Ala Leu Thr Glu Tyr Gly Gln Ser Lys Gly His Ile Asn
        2835                2840                2845            
Pro Tyr Leu Val Leu Glu Cys Ala Trp Arg Val Ser Asn Trp Thr Ala
    2850                2855                2860                
Met Lys Glu Ala Leu Val Gln Val Glu Val Ser Cys Pro Lys Glu Met
2865                2870                2875                2880
Ala Trp Lys Val Asn Met Tyr Arg Gly Tyr Leu Ala Ile Cys His Pro
                2885                2890                2895    
Glu Glu Gln Gln Leu Ser Phe Ile Glu Arg Leu Val Glu Met Ala Ser
            2900                2905                2910        
Ser Leu Ala Ile Arg Glu Trp Arg Arg Leu Pro His Val Val Ser His
        2915                2920                2925            
Val His Thr Pro Leu Leu Gln Ala Ala Gln Gln Ile Ile Glu Leu Gln
    2930                2935                2940                
Glu Ala Ala Gln Ile Asn Ala Gly Leu Gln Pro Thr Asn Leu Gly Arg
2945                2950                2955                2960
Asn Asn Ser Leu His Asp Met Lys Thr Val Val Lys Thr Trp Arg Asn
                2965                2970                2975    
Arg Leu Pro Ile Val Ser Asp Asp Leu Ser His Trp Ser Ser Ile Phe
            2980                2985                2990        
Met Trp Arg Gln His His Tyr Gln Gly Lys Pro Thr Trp Ser Gly Met
        2995                3000                3005            
His Ser Ser Ser Ile Val Thr Ala Tyr Glu Asn Ser Ser Gln His Asp
    3010                3015                3020                
Pro Ser Ser Asn Asn Ala Met Leu Gly Val His Ala Ser Ala Ser Ala
3025                3030                3035                3040
Ile Ile Gln Tyr Gly Lys Ile Ala Arg Lys Gln Gly Leu Val Asn Val
                3045                3050                3055    
Ala Leu Asp Ile Leu Ser Arg Ile His Thr Ile Pro Thr Val Pro Ile
            3060                3065                3070        
Val Asp Cys Phe Gln Lys Ile Arg Gln Gln Val Lys Cys Tyr Leu Gln
        3075                3080                3085            
Leu Ala Gly Val Met Gly Lys Asn Glu Cys Met Gln Gly Leu Glu Val
    3090                3095                3100                
Ile Glu Ser Thr Asn Leu Lys Tyr Phe Thr Lys Glu Met Thr Ala Glu
3105                3110                3115                3120
Phe Tyr Ala Leu Lys Gly Met Phe Leu Ala Gln Ile Asn Lys Ser Glu
                3125                3130                3135    
Glu Ala Asn Lys Ala Phe Ser Ala Ala Val Gln Met His Asp Val Leu
            3140                3145                3150        
Val Lys Ala Trp Ala Met Trp Gly Asp Tyr Leu Glu Asn Ile Phe Val
        3155                3160                3165            
Lys Glu Arg Gln Leu His Leu Gly Val Ser Ala Ile Thr Cys Tyr Leu
    3170                3175                3180                
His Ala Cys Arg His Gln Asn Glu Ser Lys Ser Arg Lys Tyr Leu Ala
3185                3190                3195                3200
Lys Val Leu Trp Leu Leu Ser Phe Asp Asp Asp Lys Asn Thr Leu Ala
                3205                3210                3215    
Asp Ala Val Asp Lys Tyr Cys Ile Gly Val Pro Pro Ile Gln Trp Leu
            3220                3225                3230        
Ala Trp Ile Pro Gln Leu Leu Thr Cys Leu Val Gly Ser Glu Gly Lys
        3235                3240                3245            
Leu Leu Leu Asn Leu Ile Ser Gln Val Gly Arg Val Tyr Pro Gln Ala
    3250                3255                3260                
Val Tyr Phe Pro Ile Arg Thr Leu Tyr Leu Thr Leu Lys Ile Glu Gln
3265                3270                3275                3280
Arg Glu Arg Tyr Lys Ser Asp Pro Gly Pro Ile Arg Ala Thr Ala Pro
                3285                3290                3295    
Met Trp Arg Cys Ser Arg Ile Met His Met Gln Arg Glu Leu His Pro
            3300                3305                3310        
Thr Leu Leu Ser Ser Leu Glu Gly Ile Val Asp Gln Met Val Trp Phe
        3315                3320                3325            
Arg Glu Asn Trp His Glu Glu Val Leu Arg Gln Leu Gln Gln Gly Leu
    3330                3335                3340                
Ala Lys Cys Tyr Ser Val Ala Phe Glu Lys Ser Gly Ala Val Ser Asp
3345                3350                3355                3360
Ala Lys Ile Thr Pro His Thr Leu Asn Phe Val Lys Lys Leu Val Ser
                3365                3370                3375    
Thr Phe Gly Val Gly Leu Glu Asn Val Ser Asn Val Ser Thr Met Phe
            3380                3385                3390        
Ser Ser Ala Ala Ser Glu Ser Leu Ala Arg Arg Ala Gln Ala Thr Ala
        3395                3400                3405            
Gln Asp Pro Val Phe Gln Lys Leu Lys Gly Gln Phe Thr Thr Asp Phe
    3410                3415                3420                
Asp Phe Ser Val Pro Gly Ser Met Lys Leu His Asn Leu Ile Ser Lys
3425                3430                3435                3440
Leu Lys Lys Trp Ile Lys Ile Leu Glu Ala Lys Thr Lys Gln Leu Pro
                3445                3450                3455    
Lys Phe Phe Leu Ile Glu Glu Lys Cys Arg Phe Leu Ser Asn Phe Ser
            3460                3465                3470        
Ala Gln Thr Ala Glu Val Glu Ile Pro Gly Glu Phe Leu Met Pro Lys
        3475                3480                3485            
Pro Thr His Tyr Tyr Ile Lys Ile Ala Arg Phe Met Pro Arg Val Glu
    3490                3495                3500                
Ile Val Gln Lys His Asn Thr Ala Ala Arg Arg Leu Tyr Ile Arg Gly
3505                3510                3515                3520
His Asn Gly Lys Ile Tyr Pro Tyr Leu Val Met Asn Asp Ala Cys Leu
                3525                3530                3535    
Thr Glu Ser Arg Arg Glu Glu Arg Val Leu Gln Leu Leu Arg Leu Leu
            3540                3545                3550        
Asn Pro Cys Leu Glu Lys Arg Lys Glu Thr Thr Lys Arg His Leu Phe
        3555                3560                3565            
Phe Thr Val Pro Arg Val Val Ala Val Ser Pro Gln Met Arg Leu Val
    3570                3575                3580                
Glu Asp Asn Pro Ser Ser Leu Ser Leu Val Glu Ile Tyr Lys Gln Arg
3585                3590                3595                3600
Cys Ala Lys Lys Gly Ile Glu His Asp Asn Pro Ile Ser Arg Tyr Tyr
                3605                3610                3615    
Asp Arg Leu Ala Thr Val Gln Ala Arg Gly Thr Gln Ala Ser His Gln
            3620                3625                3630        
Val Leu Arg Asp Ile Leu Lys Glu Val Gln Ser Asn Met Val Pro Arg
        3635                3640                3645            
Ser Met Leu Lys Glu Trp Ala Leu His Thr Phe Pro Asn Ala Thr Asp
    3650                3655                3660                
Tyr Trp Thr Phe Arg Lys Met Phe Thr Ile Gln Leu Ala Leu Ile Gly
3665                3670                3675                3680
Phe Ala Glu Phe Val Leu His Leu Asn Arg Leu Asn Pro Glu Met Leu
                3685                3690                3695    
Gln Ile Ala Gln Asp Thr Gly Lys Leu Asn Val Ala Tyr Phe Arg Phe
            3700                3705                3710        
Asp Ile Asn Asp Ala Thr Gly Asp Leu Asp Ala Asn Arg Pro Val Pro
        3715                3720                3725            
Phe Arg Leu Thr Pro Asn Ile Ser Glu Phe Leu Thr Thr Ile Gly Val
    3730                3735                3740                
Ser Gly Pro Leu Thr Ala Ser Met Ile Ala Val Ala Arg Cys Phe Ala
3745                3750                3755                3760
Gln Pro Asn Phe Lys Val Asp Gly Ile Leu Lys Thr Val Leu Arg Asp
                3765                3770                3775    
Glu Ile Ile Ala Trp His Lys Lys Thr Gln Glu Asp Thr Ser Ser Pro
            3780                3785                3790        
Leu Ser Ala Ala Gly Gln Pro Glu Asn Met Asp Ser Gln Gln Leu Val
        3795                3800                3805            
Ser Leu Val Gln Lys Ala Val Thr Ala Ile Met Thr Arg Leu His Asn
    3810                3815                3820                
Leu Ala Gln Phe Glu Gly Gly Glu Ser Lys Val Asn Thr Leu Val Ala
3825                3830                3835                3840
Ala Ala Asn Ser Leu Asp Asn Leu Cys Arg Met Asp Pro Ala Trp His
                3845                3850                3855    
Pro Trp Leu
            


<210> 6538
<211> 3830
<212> PRT
<213> Homo sapiens

<400> 6538
Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr
 1               5                  10                  15      
Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn
            20                  25                  30          
Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn
        35                  40                  45              
Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His
    50                  55                  60                  
Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe
65                  70                  75                  80  
Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile
                85                  90                  95      
Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn
            100                 105                 110         
Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn
        115                 120                 125             
Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg
    130                 135                 140                 
Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln
145                 150                 155                 160 
Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro
                165                 170                 175     
Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met
            180                 185                 190         
Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu
        195                 200                 205             
Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val
    210                 215                 220                 
Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys
225                 230                 235                 240 
Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn
                245                 250                 255     
Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr
            260                 265                 270         
Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu
        275                 280                 285             
Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys
    290                 295                 300                 
Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys
305                 310                 315                 320 
Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys
                325                 330                 335     
His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp
            340                 345                 350         
Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg
        355                 360                 365             
Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His
    370                 375                 380                 
His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln
385                 390                 395                 400 
Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln
                405                 410                 415     
Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser
            420                 425                 430         
Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met
        435                 440                 445             
Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu
    450                 455                 460                 
Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val
465                 470                 475                 480 
Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro
                485                 490                 495     
Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro
            500                 505                 510         
Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu
        515                 520                 525             
Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr
    530                 535                 540                 
Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile
545                 550                 555                 560 
Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile
                565                 570                 575     
Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu
            580                 585                 590         
Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala
        595                 600                 605             
Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg
    610                 615                 620                 
Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr
625                 630                 635                 640 
Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro
                645                 650                 655     
Tyr Met Val Asp Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala
            660                 665                 670         
Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile
        675                 680                 685             
Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val
    690                 695                 700                 
Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser
705                 710                 715                 720 
Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu
                725                 730                 735     
His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu
            740                 745                 750         
Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly
        755                 760                 765             
Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro
    770                 775                 780                 
Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln
785                 790                 795                 800 
His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg
                805                 810                 815     
Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val
            820                 825                 830         
Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr
        835                 840                 845             
Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His
    850                 855                 860                 
Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu
865                 870                 875                 880 
Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly
                885                 890                 895     
Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu
            900                 905                 910         
His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe
        915                 920                 925             
Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu
    930                 935                 940                 
Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg
945                 950                 955                 960 
Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser
                965                 970                 975     
Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn
            980                 985                 990         
Phe Thr Glu Lys Thr Ile Pro Asn Val Ile Ile Ser His Arg Tyr Lys
        995                 1000                1005            
Ala Gln Asp Thr Pro Ala Arg Lys Thr Phe Glu Gln Ala Leu Thr Gly
    1010                1015                1020                
Ala Phe Met Ser Ala Val Ile Lys Asp Leu Arg Pro Ser Ala Leu Pro
1025                1030                1035                1040
Phe Val Ala Ser Leu Ile Arg His Tyr Thr Met Val Ala Val Ala Gln
                1045                1050                1055    
Gln Cys Gly Pro Phe Leu Leu Pro Cys Tyr Gln Val Gly Ser Gln Pro
            1060                1065                1070        
Ser Thr Ala Met Phe His Ser Glu Glu Asn Gly Ser Lys Gly Met Asp
        1075                1080                1085            
Pro Leu Val Leu Ile Asp Ala Ile Ala Ile Cys Met Ala Tyr Glu Glu
    1090                1095                1100                
Lys Glu Leu Cys Lys Ile Gly Glu Val Ala Leu Ala Val Ile Phe Asp
1105                1110                1115                1120
Val Ala Ser Ile Ile Leu Gly Ser Lys Glu Arg Ala Cys Gln Leu Pro
                1125                1130                1135    
Leu Phe Ser Tyr Ile Val Glu Arg Leu Cys Ala Cys Cys Tyr Glu Gln
            1140                1145                1150        
Ala Trp Tyr Ala Lys Leu Gly Gly Val Val Ser Ile Lys Phe Leu Met
        1155                1160                1165            
Glu Arg Leu Pro Leu Thr Trp Val Leu Gln Asn Gln Gln Thr Phe Leu
    1170                1175                1180                
Lys Ala Leu Leu Phe Val Met Met Asp Leu Thr Gly Glu Val Ser Asn
1185                1190                1195                1200
Gly Ala Val Ala Met Ala Lys Thr Thr Leu Glu Gln Leu Leu Met Arg
                1205                1210                1215    
Cys Ala Thr Pro Leu Lys Asp Glu Glu Arg Ala Glu Glu Ile Val Ala
            1220                1225                1230        
Ala Gln Glu Lys Ser Phe His His Val Thr His Asp Leu Val Arg Glu
        1235                1240                1245            
Val Thr Ser Pro Asn Ser Thr Val Arg Lys Gln Ala Met His Ser Leu
    1250                1255                1260                
Gln Val Leu Ala Gln Val Thr Gly Lys Ser Val Thr Val Ile Met Glu
1265                1270                1275                1280
Pro His Lys Glu Val Leu Gln Asp Met Val Pro Pro Lys Lys His Leu
                1285                1290                1295    
Leu Arg His Gln Pro Ala Asn Ala Gln Ile Gly Leu Met Glu Gly Asn
            1300                1305                1310        
Thr Phe Cys Thr Thr Leu Gln Pro Arg Leu Phe Thr Met Asp Leu Asn
        1315                1320                1325            
Val Val Glu His Lys Val Phe Tyr Thr Glu Leu Leu Asn Leu Cys Glu
    1330                1335                1340                
Ala Glu Asp Ser Ala Leu Thr Lys Leu Pro Cys Tyr Lys Ser Leu Pro
1345                1350                1355                1360
Ser Leu Val Pro Leu Arg Ile Ala Ala Leu Asn Ala Leu Ala Ala Cys
                1365                1370                1375    
Asn Tyr Leu Pro Gln Ser Arg Glu Lys Ile Ile Ala Ala Leu Phe Lys
            1380                1385                1390        
Ala Leu Asn Ser Thr Asn Ser Glu Leu Gln Glu Ala Gly Glu Ala Cys
        1395                1400                1405            
Met Arg Lys Phe Leu Glu Gly Ala Thr Ile Glu Val Asp Gln Ile His
    1410                1415                1420                
Thr His Met Arg Pro Leu Leu Met Met Leu Gly Asp Tyr Arg Ser Leu
1425                1430                1435                1440
Thr Leu Asn Val Val Asn Arg Leu Thr Ser Val Thr Arg Leu Phe Pro
                1445                1450                1455    
Asn Ser Phe Asn Asp Lys Phe Cys Asp Gln Met Met Gln His Leu Arg
            1460                1465                1470        
Lys Trp Met Glu Val Val Val Ile Thr His Lys Gly Gly Gln Arg Ser
        1475                1480                1485            
Asp Gly Asn Glu Met Lys Ile Cys Ser Ala Ile Ile Asn Leu Phe His
    1490                1495                1500                
Leu Ile Pro Ala Ala Pro Gln Thr Leu Val Lys Pro Leu Leu Glu Val
1505                1510                1515                1520
Val Met Lys Thr Glu Arg Ala Met Leu Ile Glu Ala Gly Ser Pro Phe
                1525                1530                1535    
Arg Glu Pro Leu Ile Lys Phe Leu Thr Arg His Pro Ser Gln Thr Val
            1540                1545                1550        
Glu Leu Phe Met Met Glu Ala Thr Leu Asn Asp Pro Gln Trp Ser Arg
        1555                1560                1565            
Met Phe Met Ser Phe Leu Lys His Lys Asp Ala Arg Pro Leu Arg Asp
    1570                1575                1580                
Val Leu Ala Ala Asn Pro Asn Arg Phe Ile Thr Leu Leu Leu Pro Gly
1585                1590                1595                1600
Gly Ala Gln Thr Ala Val Arg Pro Gly Ser Pro Ser Thr Ser Thr Met
                1605                1610                1615    
Arg Leu Asp Leu Gln Phe Gln Ala Ile Lys Ile Ile Ser Ile Ile Val
            1620                1625                1630        
Lys Asn Asp Asp Ser Trp Leu Ala Ser Gln His Ser Leu Val Ser Gln
        1635                1640                1645            
Leu Arg Arg Val Trp Val Ser Glu Asn Phe Gln Glu Arg His Arg Lys
    1650                1655                1660                
Glu Asn Met Ala Ala Thr Asn Trp Lys Glu Pro Lys Leu Leu Ala Tyr
1665                1670                1675                1680
Cys Leu Leu Asn Tyr Cys Lys Arg Asn Tyr Gly Asp Ile Glu Leu Leu
                1685                1690                1695    
Phe Gln Leu Leu Arg Ala Phe Thr Gly Arg Phe Leu Cys Asn Met Thr
            1700                1705                1710        
Phe Leu Lys Glu Tyr Met Glu Glu Glu Ile Pro Lys Asn Tyr Ser Ile
        1715                1720                1725            
Ala Gln Lys Arg Ala Leu Phe Phe Arg Phe Val Asp Phe Asn Asp Pro
    1730                1735                1740                
Asn Phe Gly Asp Glu Leu Lys Ala Lys Val Leu Gln His Ile Leu Asn
1745                1750                1755                1760
Pro Ala Phe Leu Tyr Ser Phe Glu Lys Gly Glu Gly Glu Gln Leu Leu
                1765                1770                1775    
Gly Pro Pro Asn Pro Glu Gly Asp Asn Pro Glu Ser Ile Thr Ser Val
            1780                1785                1790        
Phe Ile Thr Lys Val Leu Asp Pro Glu Lys Gln Ala Asp Met Leu Asp
        1795                1800                1805            
Ser Leu Arg Ile Tyr Leu Leu Gln Tyr Ala Thr Leu Leu Val Glu His
    1810                1815                1820                
Ala Pro His His Ile His Asp Asn Asn Lys Asn Arg Asn Ser Lys Leu
1825                1830                1835                1840
Arg Arg Leu Met Thr Phe Ala Trp Pro Cys Leu Leu Ser Lys Ala Cys
                1845                1850                1855    
Val Asp Pro Ala Cys Lys Tyr Ser Gly His Leu Leu Leu Ala His Ile
            1860                1865                1870        
Ile Ala Lys Phe Ala Ile His Lys Lys Ile Val Leu Gln Val Phe His
        1875                1880                1885            
Ser Leu Leu Lys Ala His Ala Met Glu Ala Arg Ala Ile Val Arg Gln
    1890                1895                1900                
Ala Met Ala Ile Leu Thr Pro Ala Val Pro Ala Arg Met Glu Asp Gly
1905                1910                1915                1920
His Gln Met Leu Thr His Trp Thr Arg Lys Ile Ile Val Glu Glu Gly
                1925                1930                1935    
His Thr Val Pro Gln Leu Val His Ile Leu His Leu Ile Val Gln His
            1940                1945                1950        
Phe Lys Val Tyr Tyr Pro Val Arg His His Leu Val Gln His Met Val
        1955                1960                1965            
Ser Ala Met Gln Arg Leu Gly Phe Thr Pro Ser Val Thr Ile Glu Gln
    1970                1975                1980                
Arg Arg Leu Ala Val Asp Leu Ser Glu Val Val Ile Lys Trp Glu Leu
1985                1990                1995                2000
Gln Arg Ile Lys Asp Gln Gln Pro Asp Ser Asp Met Asp Pro Asn Ser
                2005                2010                2015    
Ser Gly Glu Gly Val Asn Ser Val Ser Ser Ser Ile Lys Arg Gly Leu
            2020                2025                2030        
Ser Val Asp Ser Ala Gln Glu Val Lys Arg Phe Arg Thr Ala Thr Gly
        2035                2040                2045            
Ala Ile Ser Ala Val Phe Gly Arg Ser Gln Ser Leu Pro Gly Ala Asp
    2050                2055                2060                
Ser Leu Leu Ala Lys Pro Ile Asp Lys Gln His Thr Asp Thr Val Val
2065                2070                2075                2080
Asn Phe Leu Ile Arg Val Ala Cys Gln Val Asn Asp Asn Thr Asn Thr
                2085                2090                2095    
Ala Gly Ser Pro Gly Glu Val Leu Ser Arg Arg Cys Val Asn Leu Leu
            2100                2105                2110        
Lys Thr Ala Leu Arg Pro Asp Met Trp Pro Lys Ser Glu Leu Lys Leu
        2115                2120                2125            
Gln Trp Phe Asp Lys Leu Leu Met Thr Val Glu Gln Pro Asn Gln Val
    2130                2135                2140                
Asn Tyr Gly Asn Ile Cys Thr Gly Leu Glu Val Leu Ser Phe Leu Leu
2145                2150                2155                2160
Thr Val Leu Gln Ser Pro Ala Ile Leu Ser Ser Phe Lys Pro Leu Gln
                2165                2170                2175    
Arg Gly Ile Ala Ala Cys Met Thr Cys Gly Asn Thr Lys Val Leu Arg
            2180                2185                2190        
Ala Val His Ser Leu Leu Ser Arg Leu Met Ser Ile Phe Pro Thr Glu
        2195                2200                2205            
Pro Ser Thr Ser Ser Val Ala Ser Lys Tyr Glu Glu Leu Glu Cys Leu
    2210                2215                2220                
Tyr Ala Ala Val Gly Lys Val Ile Tyr Glu Gly Leu Thr Asn Tyr Glu
2225                2230                2235                2240
Lys Ala Thr Asn Ala Asn Pro Ser Gln Leu Phe Gly Thr Leu Met Ile
                2245                2250                2255    
Leu Lys Ser Ala Cys Ser Asn Asn Pro Ser Tyr Ile Asp Arg Leu Ile
            2260                2265                2270        
Ser Val Phe Met Arg Ser Leu Gln Lys Met Val Arg Glu His Leu Asn
        2275                2280                2285            
Pro Gln Ala Ala Ser Gly Ser Thr Glu Ala Thr Ser Gly Thr Ser Glu
    2290                2295                2300                
Leu Val Met Leu Ser Leu Glu Leu Val Lys Thr Arg Leu Ala Val Met
2305                2310                2315                2320
Ser Met Glu Met Arg Lys Asn Phe Ile Gln Ala Ile Leu Thr Ser Leu
                2325                2330                2335    
Ile Glu Lys Ser Pro Asp Ala Lys Ile Leu Arg Ala Val Val Lys Ile
            2340                2345                2350        
Val Glu Glu Trp Val Lys Asn Asn Ser Pro Met Ala Ala Asn Gln Thr
        2355                2360                2365            
Pro Thr Leu Arg Glu Lys Ser Ile Leu Leu Val Lys Met Met Thr Tyr
    2370                2375                2380                
Ile Glu Lys Arg Phe Pro Glu Asp Leu Glu Leu Asn Ala Gln Phe Leu
2385                2390                2395                2400
Asp Leu Val Asn Tyr Val Tyr Arg Asp Glu Thr Leu Ser Gly Ser Glu
                2405                2410                2415    
Leu Thr Ala Lys Leu Glu Pro Ala Phe Leu Ser Gly Leu Arg Cys Ala
            2420                2425                2430        
Gln Pro Leu Ile Arg Ala Lys Phe Phe Glu Val Phe Asp Asn Ser Met
        2435                2440                2445            
Lys Arg Arg Val Tyr Glu Arg Leu Leu Tyr Val Thr Cys Ser Gln Asn
    2450                2455                2460                
Trp Glu Ala Met Gly Asn His Phe Trp Ile Lys Gln Cys Ile Glu Leu
2465                2470                2475                2480
Leu Leu Ala Val Cys Glu Lys Ser Thr Pro Ile Gly Thr Ser Cys Gln
                2485                2490                2495    
Gly Ala Met Leu Pro Ser Ile Thr Asn Val Ile Asn Leu Ala Asp Ser
            2500                2505                2510        
His Asp Arg Ala Ala Phe Ala Met Val Thr His Val Lys Gln Glu Pro
        2515                2520                2525            
Arg Glu Arg Glu Asn Ser Glu Ser Lys Glu Glu Asp Val Glu Ile Asp
    2530                2535                2540                
Ile Glu Leu Ala Pro Gly Asp Gln Thr Ser Thr Pro Lys Thr Lys Glu
2545                2550                2555                2560
Leu Ser Glu Lys Asp Ile Gly Asn Gln Leu His Met Leu Thr Asn Arg
                2565                2570                2575    
His Asp Lys Phe Leu Asp Thr Leu Arg Glu Val Lys Thr Gly Ala Leu
            2580                2585                2590        
Leu Ser Ala Phe Val Gln Leu Cys His Ile Ser Thr Thr Leu Ala Glu
        2595                2600                2605            
Lys Thr Trp Val Gln Leu Phe Pro Arg Leu Trp Lys Ile Leu Ser Asp
    2610                2615                2620                
Arg Gln Gln His Ala Leu Ala Gly Glu Ile Ser Pro Phe Leu Cys Ser
2625                2630                2635                2640
Gly Ser His Gln Val Gln Arg Asp Cys Gln Pro Ser Ala Leu Asn Cys
                2645                2650                2655    
Phe Val Glu Ala Met Ser Gln Cys Val Pro Pro Ile Pro Ile Arg Pro
            2660                2665                2670        
Cys Val Leu Lys Tyr Leu Gly Lys Thr His Asn Leu Trp Phe Arg Ser
        2675                2680                2685            
Thr Leu Met Leu Glu His Gln Ala Phe Glu Lys Gly Leu Ser Leu Gln
    2690                2695                2700                
Ile Lys Pro Lys Gln Thr Thr Glu Phe Tyr Glu Gln Glu Ser Ile Thr
2705                2710                2715                2720
Pro Pro Gln Gln Glu Ile Leu Asp Ser Leu Ala Glu Leu Tyr Ser Leu
                2725                2730                2735    
Leu Gln Glu Glu Asp Met Trp Ala Gly Leu Trp Gln Lys Arg Cys Lys
            2740                2745                2750        
Tyr Ser Glu Thr Ala Thr Ala Ile Ala Tyr Glu Gln His Gly Phe Phe
        2755                2760                2765            
Glu Gln Ala Gln Glu Ser Tyr Glu Lys Ala Met Asp Lys Ala Lys Lys
    2770                2775                2780                
Glu His Glu Arg Ser Asn Ala Ser Pro Ala Ile Phe Pro Glu Tyr Gln
2785                2790                2795                2800
Leu Trp Glu Asp His Trp Ile Arg Cys Ser Lys Glu Leu Asn Gln Trp
                2805                2810                2815    
Glu Ala Leu Thr Glu Tyr Gly Gln Ser Lys Gly His Ile Asn Pro Tyr
            2820                2825                2830        
Leu Val Leu Glu Cys Ala Trp Arg Val Ser Asn Trp Thr Ala Met Lys
        2835                2840                2845            
Glu Ala Leu Val Gln Val Glu Val Ser Cys Pro Lys Glu Met Ala Trp
    2850                2855                2860                
Lys Val Asn Met Tyr Arg Gly Tyr Leu Ala Ile Cys His Pro Glu Glu
2865                2870                2875                2880
Gln Gln Leu Ser Phe Ile Glu Arg Leu Val Glu Met Ala Ser Ser Leu
                2885                2890                2895    
Ala Ile Arg Glu Trp Arg Arg Leu Pro His Val Val Ser His Val His
            2900                2905                2910        
Thr Pro Leu Leu Gln Ala Ala Gln Gln Ile Ile Glu Leu Gln Glu Ala
        2915                2920                2925            
Ala Gln Ile Asn Ala Gly Leu Gln Pro Thr Asn Leu Gly Arg Asn Asn
    2930                2935                2940                
Ser Leu His Asp Met Lys Thr Val Val Lys Thr Trp Arg Asn Arg Leu
2945                2950                2955                2960
Pro Ile Val Ser Asp Asp Leu Ser His Trp Ser Ser Ile Phe Met Trp
                2965                2970                2975    
Arg Gln His His Tyr Gln Ala Ile Val Thr Ala Tyr Glu Asn Ser Ser
            2980                2985                2990        
Gln His Asp Pro Ser Ser Asn Asn Ala Met Leu Gly Val His Ala Ser
        2995                3000                3005            
Ala Ser Ala Ile Ile Gln Tyr Gly Lys Ile Ala Arg Lys Gln Gly Leu
    3010                3015                3020                
Val Asn Val Ala Leu Asp Ile Leu Ser Arg Ile His Thr Ile Pro Thr
3025                3030                3035                3040
Val Pro Ile Val Asp Cys Phe Gln Lys Ile Arg Gln Gln Val Lys Cys
                3045                3050                3055    
Tyr Leu Gln Leu Ala Gly Val Met Gly Lys Asn Glu Cys Met Gln Gly
            3060                3065                3070        
Leu Glu Val Ile Glu Ser Thr Asn Leu Lys Tyr Phe Thr Lys Glu Met
        3075                3080                3085            
Thr Ala Glu Phe Tyr Ala Leu Lys Gly Met Phe Leu Ala Gln Ile Asn
    3090                3095                3100                
Lys Ser Glu Glu Ala Asn Lys Ala Phe Ser Ala Ala Val Gln Met His
3105                3110                3115                3120
Asp Val Leu Val Lys Ala Trp Ala Met Trp Gly Asp Tyr Leu Glu Asn
                3125                3130                3135    
Ile Phe Val Lys Glu Arg Gln Leu His Leu Gly Val Ser Ala Ile Thr
            3140                3145                3150        
Cys Tyr Leu His Ala Cys Arg His Gln Asn Glu Ser Lys Ser Arg Lys
        3155                3160                3165            
Tyr Leu Ala Lys Val Leu Trp Leu Leu Ser Phe Asp Asp Asp Lys Asn
    3170                3175                3180                
Thr Leu Ala Asp Ala Val Asp Lys Tyr Cys Ile Gly Val Pro Pro Ile
3185                3190                3195                3200
Gln Trp Leu Ala Trp Ile Pro Gln Leu Leu Thr Cys Leu Val Gly Ser
                3205                3210                3215    
Glu Gly Lys Leu Leu Leu Asn Leu Ile Ser Gln Val Gly Arg Val Tyr
            3220                3225                3230        
Pro Gln Ala Val Tyr Phe Pro Ile Arg Thr Leu Tyr Leu Thr Leu Lys
        3235                3240                3245            
Ile Glu Gln Arg Glu Arg Tyr Lys Ser Asp Pro Gly Pro Ile Arg Ala
    3250                3255                3260                
Thr Ala Pro Met Trp Arg Cys Ser Arg Ile Met His Met Gln Arg Glu
3265                3270                3275                3280
Leu His Pro Thr Leu Leu Ser Ser Leu Glu Gly Ile Val Asp Gln Met
                3285                3290                3295    
Val Trp Phe Arg Glu Asn Trp His Glu Glu Val Leu Arg Gln Leu Gln
            3300                3305                3310        
Gln Gly Leu Ala Lys Cys Tyr Ser Val Ala Phe Glu Lys Ser Gly Ala
        3315                3320                3325            
Val Ser Asp Ala Lys Ile Thr Pro His Thr Leu Asn Phe Val Lys Lys
    3330                3335                3340                
Leu Val Ser Thr Phe Gly Val Gly Leu Glu Asn Val Ser Asn Val Ser
3345                3350                3355                3360
Thr Met Phe Ser Ser Ala Ala Ser Glu Ser Leu Ala Arg Arg Ala Gln
                3365                3370                3375    
Ala Thr Ala Gln Asp Pro Val Phe Gln Lys Leu Lys Gly Gln Phe Thr
            3380                3385                3390        
Thr Asp Phe Asp Phe Ser Val Pro Gly Ser Met Lys Leu His Asn Leu
        3395                3400                3405            
Ile Ser Lys Leu Lys Lys Trp Ile Lys Ile Leu Glu Ala Lys Thr Lys
    3410                3415                3420                
Gln Leu Pro Lys Phe Phe Leu Ile Glu Glu Lys Cys Arg Phe Leu Ser
3425                3430                3435                3440
Asn Phe Ser Ala Gln Thr Ala Glu Val Glu Ile Pro Gly Glu Phe Leu
                3445                3450                3455    
Met Pro Lys Pro Thr His Tyr Tyr Ile Lys Ile Ala Arg Phe Met Pro
            3460                3465                3470        
Arg Val Glu Ile Val Gln Lys His Asn Thr Ala Ala Arg Arg Leu Tyr
        3475                3480                3485            
Ile Arg Gly His Asn Gly Lys Ile Tyr Pro Tyr Leu Val Met Asn Asp
    3490                3495                3500                
Ala Cys Leu Thr Glu Ser Arg Arg Glu Glu Arg Val Leu Gln Leu Leu
3505                3510                3515                3520
Arg Leu Leu Asn Pro Cys Leu Glu Lys Arg Lys Glu Thr Thr Lys Arg
                3525                3530                3535    
His Leu Phe Phe Thr Val Pro Arg Val Val Ala Val Ser Pro Gln Met
            3540                3545                3550        
Arg Leu Val Glu Asp Asn Pro Ser Ser Leu Ser Leu Val Glu Ile Tyr
        3555                3560                3565            
Lys Gln Arg Cys Ala Lys Lys Gly Ile Glu His Asp Asn Pro Ile Ser
    3570                3575                3580                
Arg Tyr Tyr Asp Arg Leu Ala Thr Val Gln Ala Arg Gly Thr Gln Ala
3585                3590                3595                3600
Ser His Gln Val Leu Arg Asp Ile Leu Lys Glu Val Gln Ser Asn Met
                3605                3610                3615    
Val Pro Arg Ser Met Leu Lys Glu Trp Ala Leu His Thr Phe Pro Asn
            3620                3625                3630        
Ala Thr Asp Tyr Trp Thr Phe Arg Lys Met Phe Thr Ile Gln Leu Ala
        3635                3640                3645            
Leu Ile Gly Phe Ala Glu Phe Val Leu His Leu Asn Arg Leu Asn Pro
    3650                3655                3660                
Glu Met Leu Gln Ile Ala Gln Asp Thr Gly Lys Leu Asn Val Ala Tyr
3665                3670                3675                3680
Phe Arg Phe Asp Ile Asn Asp Ala Thr Gly Asp Leu Asp Ala Asn Arg
                3685                3690                3695    
Pro Val Pro Phe Arg Leu Thr Pro Asn Ile Ser Glu Phe Leu Thr Thr
            3700                3705                3710        
Ile Gly Val Ser Gly Pro Leu Thr Ala Ser Met Ile Ala Val Ala Arg
        3715                3720                3725            
Cys Phe Ala Gln Pro Asn Phe Lys Val Asp Gly Ile Leu Lys Thr Val
    3730                3735                3740                
Leu Arg Asp Glu Ile Ile Ala Trp His Lys Lys Thr Gln Glu Asp Thr
3745                3750                3755                3760
Ser Ser Pro Leu Ser Ala Ala Gly Gln Pro Glu Asn Met Asp Ser Gln
                3765                3770                3775    
Gln Leu Val Ser Leu Val Gln Lys Ala Val Thr Ala Ile Met Thr Arg
            3780                3785                3790        
Leu His Asn Leu Ala Gln Phe Glu Gly Gly Glu Ser Lys Val Asn Thr
        3795                3800                3805            
Leu Val Ala Ala Ala Asn Ser Leu Asp Asn Leu Cys Arg Met Asp Pro
    3810                3815                3820                
Ala Trp His Pro Trp Leu
3825                3830


<210> 6539
<211> 1443
<212> PRT
<213> Homo sapiens

<400> 6539
Glu Gln Pro Asn Gln Val Asn Tyr Gly Asn Ile Cys Thr Gly Leu Glu
 1               5                  10                  15      
Val Leu Ser Phe Leu Leu Thr Val Leu Gln Ser Pro Ala Ile Leu Ser
            20                  25                  30          
Ser Phe Lys Pro Leu Gln Arg Gly Ile Ala Ala Cys Met Thr Cys Gly
        35                  40                  45              
Asn Thr Lys Val Leu Arg Ala Val His Ser Leu Leu Ser Arg Leu Met
    50                  55                  60                  
Ser Ile Phe Pro Thr Glu Pro Lys Tyr Ile Val Leu Asn Asn Val Leu
65                  70                  75                  80  
Leu Ser Leu Cys Phe Ser Trp Leu Leu Leu Phe Cys Glu Thr Leu Gly
                85                  90                  95      
Asn Phe Tyr Ile Leu Gly Thr Leu Met Ile Leu Lys Ser Ala Cys Ser
            100                 105                 110         
Asn Asn Pro Ser Tyr Ile Asp Arg Leu Ile Ser Val Phe Met Arg Ser
        115                 120                 125             
Leu Gln Lys Met Val Arg Glu His Leu Asn Pro Gln Ala Ala Ser Gly
    130                 135                 140                 
Ser Thr Glu Ala Thr Ser Gly Thr Ser Glu Leu Val Met Leu Ser Leu
145                 150                 155                 160 
Glu Leu Val Lys Thr Arg Leu Ala Val Met Ser Met Glu Met Arg Lys
                165                 170                 175     
Asn Phe Ile Gln Ala Ile Leu Thr Ser Leu Ile Glu Lys Ser Pro Asp
            180                 185                 190         
Ala Lys Ile Leu Arg Ala Val Val Lys Ile Val Glu Glu Trp Val Lys
        195                 200                 205             
Asn Asn Ser Pro Met Ala Ala Asn Gln Thr Pro Thr Leu Arg Glu Lys
    210                 215                 220                 
Ser Ile Leu Leu Val Lys Met Met Thr Tyr Ile Glu Lys Arg Phe Pro
225                 230                 235                 240 
Glu Asp Leu Glu Leu Asn Ala Gln Phe Leu Asp Leu Val Asn Tyr Val
                245                 250                 255     
Tyr Arg Asp Glu Thr Leu Ser Gly Ser Glu Leu Thr Ala Lys Leu Glu
            260                 265                 270         
Pro Ala Phe Leu Ser Gly Leu Arg Cys Ala Gln Pro Leu Ile Arg Ala
        275                 280                 285             
Lys Phe Phe Glu Val Phe Asp Asn Ser Met Lys Arg Arg Val Tyr Glu
    290                 295                 300                 
Arg Leu Leu Tyr Val Thr Cys Ser Gln Asn Trp Glu Ala Met Gly Asn
305                 310                 315                 320 
His Phe Trp Ile Lys Gln Cys Ile Glu Thr Gly Ala Leu Leu Ser Ala
                325                 330                 335     
Phe Val Gln Leu Cys His Ile Ser Thr Thr Leu Ala Glu Lys Thr Trp
            340                 345                 350         
Val Gln Leu Phe Pro Arg Leu Trp Lys Ile Leu Ser Asp Arg Gln Gln
        355                 360                 365             
His Ala Leu Ala Gly Glu Ile Ser Pro Phe Leu Cys Ser Gly Ser His
    370                 375                 380                 
Gln Val Gln Arg Asp Cys Gln Pro Ser Ala Leu Asn Cys Phe Val Glu
385                 390                 395                 400 
Ala Met Ser Gln Cys Val Pro Pro Ile Pro Ile Arg Pro Cys Val Leu
                405                 410                 415     
Lys Tyr Leu Gly Lys Thr His Asn Leu Trp Phe Arg Ser Thr Leu Met
            420                 425                 430         
Leu Glu His Gln Ala Phe Glu Lys Gly Leu Ser Leu Gln Ile Lys Pro
        435                 440                 445             
Lys Gln Thr Thr Glu Phe Tyr Glu Gln Glu Ser Ile Thr Pro Pro Gln
    450                 455                 460                 
Gln Glu Ile Leu Asp Ser Leu Ala Glu Leu Tyr Ser Leu Leu Gln Glu
465                 470                 475                 480 
Glu Asp Met Trp Ala Gly Leu Trp Gln Lys Arg Cys Lys Tyr Ser Glu
                485                 490                 495     
Thr Ala Thr Ala Ile Ala Tyr Glu Gln His Gly Phe Phe Glu Gln Ala
            500                 505                 510         
Gln Glu Ser Tyr Glu Lys Ala Met Asp Lys Ala Lys Lys Glu His Glu
        515                 520                 525             
Arg Ser Asn Ala Ser Pro Ala Ile Phe Pro Glu Tyr Gln Leu Trp Glu
    530                 535                 540                 
Asp His Trp Ile Arg Cys Ser Lys Glu Leu Asn Gln Trp Glu Ala Leu
545                 550                 555                 560 
Thr Glu Tyr Gly Gln Ser Lys Gly His Ile Asn Pro Tyr Leu Val Leu
                565                 570                 575     
Glu Cys Ala Trp Arg Val Ser Asn Trp Thr Ala Met Lys Glu Ala Leu
            580                 585                 590         
Val Gln Val Glu Val Ser Cys Pro Lys Glu Met Ala Trp Lys Val Asn
        595                 600                 605             
Met Tyr Arg Gly Tyr Leu Ala Ile Cys His Pro Glu Glu Gln Gln Leu
    610                 615                 620                 
Ser Phe Ile Glu Arg Leu Val Glu Met Ala Ser Ser Leu Ala Ile Arg
625                 630                 635                 640 
Glu Trp Arg Arg Leu Pro His Val Val Ser His Val His Thr Pro Leu
                645                 650                 655     
Leu Gln Ser Leu Leu Cys Trp Ser His Gln Ala Ala Gln Gln Ile Ile
            660                 665                 670         
Glu Leu Gln Glu Ala Ala Gln Ile Asn Ala Gly Leu Gln Pro Thr Asn
        675                 680                 685             
Leu Gly Arg Asn Asn Ser Leu His Asp Met Lys Thr Val Val Lys Thr
    690                 695                 700                 
Trp Arg Asn Arg Leu Pro Ile Val Ser Asp Asp Leu Ser His Trp Ser
705                 710                 715                 720 
Ser Ile Phe Met Trp Arg Gln His His Tyr Gln Ala Ile Val Thr Ala
                725                 730                 735     
Tyr Glu Asn Ser Ser Gln His Asp Pro Ser Ser Asn Asn Ala Met Leu
            740                 745                 750         
Gly Val His Ala Ser Ala Ser Ala Ile Ile Gln Tyr Gly Lys Ile Ala
        755                 760                 765             
Arg Lys Gln Gly Leu Val Asn Val Ala Leu Asp Ile Leu Ser Arg Ile
    770                 775                 780                 
His Thr Ile Pro Thr Val Pro Ile Val Asp Cys Phe Gln Lys Ile Arg
785                 790                 795                 800 
Gln Gln Val Lys Cys Tyr Leu Gln Leu Ala Gly Val Met Gly Lys Asn
                805                 810                 815     
Glu Cys Met Gln Gly Leu Glu Val Ile Glu Ser Thr Asn Leu Lys Tyr
            820                 825                 830         
Phe Thr Lys Glu Met Thr Ala Glu Phe Tyr Ala Leu Lys Gly Met Phe
        835                 840                 845             
Leu Ala Gln Ile Asn Lys Ser Glu Glu Ala Asn Lys Ala Phe Ser Ala
    850                 855                 860                 
Ala Val Gln Met His Asp Val Leu Val Lys Ala Trp Ala Met Trp Gly
865                 870                 875                 880 
Asp Tyr Leu Glu Asn Ile Phe Val Lys Glu Arg Gln Leu His Leu Gly
                885                 890                 895     
Val Ser Ala Ile Thr Cys Tyr Leu His Ala Cys Arg His Gln Asn Glu
            900                 905                 910         
Ser Lys Ser Arg Lys Tyr Leu Ala Lys Val Leu Trp Leu Leu Ser Phe
        915                 920                 925             
Asp Asp Asp Lys Asn Thr Leu Ala Asp Ala Val Asp Lys Tyr Cys Ile
    930                 935                 940                 
Gly Val Pro Pro Ile Gln Trp Leu Ala Trp Ile Pro Gln Leu Leu Thr
945                 950                 955                 960 
Cys Leu Val Gly Ser Glu Gly Lys Leu Leu Leu Asn Leu Ile Ser Gln
                965                 970                 975     
Val Gly Arg Val Tyr Pro Gln Ala Val Tyr Phe Pro Ile Arg Thr Leu
            980                 985                 990         
Tyr Leu Thr Leu Lys Ile Glu Gln Arg Glu Arg Tyr Lys Ser Asp Phe
        995                 1000                1005            
Asp Phe Ser Val Pro Gly Ser Met Lys Leu His Asn Leu Ile Ser Lys
    1010                1015                1020                
Leu Lys Lys Trp Ile Lys Ile Leu Glu Ala Lys Thr Lys Gln Leu Pro
1025                1030                1035                1040
Lys Phe Phe Leu Ile Glu Glu Lys Cys Arg Phe Leu Ser Asn Phe Ser
                1045                1050                1055    
Ala Gln Thr Ala Glu Val Glu Ile Pro Gly Glu Phe Leu Met Pro Lys
            1060                1065                1070        
Pro Thr His Tyr Tyr Ile Lys Ile Ala Arg Phe Met Pro Arg Val Glu
        1075                1080                1085            
Ile Val Gln Lys His Asn Thr Ala Ala Arg Arg Leu Tyr Ile Arg Gly
    1090                1095                1100                
His Asn Gly Lys Ile Tyr Pro Tyr Leu Val Met Asn Asp Ala Cys Leu
1105                1110                1115                1120
Thr Glu Ser Arg Arg Glu Glu Arg Val Leu Gln Leu Leu Arg Leu Leu
                1125                1130                1135    
Asn Pro Cys Leu Glu Lys Arg Lys Glu Thr Thr Lys Arg His Leu Phe
            1140                1145                1150        
Phe Thr Val Pro Arg Val Val Ala Val Ser Pro Gln Met Arg Leu Val
        1155                1160                1165            
Glu Asp Asn Pro Ser Ser Leu Ser Leu Val Glu Ile Tyr Lys Gln Arg
    1170                1175                1180                
Cys Ala Lys Lys Gly Ile Glu His Asp Asn Pro Ile Ser Arg Tyr Tyr
1185                1190                1195                1200
Asp Arg Leu Ala Thr Val Gln Ala Arg Gly Thr Gln Ala Ser His Gln
                1205                1210                1215    
Val Leu Arg Asp Ile Leu Lys Glu Val Gln Ser Asn Met Val Pro Arg
            1220                1225                1230        
Ser Met Leu Lys Glu Trp Ala Leu His Thr Phe Pro Asn Ala Thr Asp
        1235                1240                1245            
Tyr Trp Thr Phe Arg Lys Met Phe Thr Ile Gln Leu Ala Leu Ile Gly
    1250                1255                1260                
Phe Ala Glu Phe Val Leu His Leu Asn Arg Leu Asn Pro Glu Met Leu
1265                1270                1275                1280
Gln Ile Ala Gln Asp Thr Gly Lys Leu Asn Val Ala Tyr Phe Arg Phe
                1285                1290                1295    
Asp Ile Asn Asp Ala Thr Gly Asp Leu Asp Ala Asn Arg Pro Val Pro
            1300                1305                1310        
Phe Arg Leu Thr Pro Asn Ile Ser Glu Phe Leu Thr Thr Ile Gly Val
        1315                1320                1325            
Ser Gly Pro Leu Thr Ala Ser Met Ile Ala Val Ala Arg Cys Phe Ala
    1330                1335                1340                
Gln Pro Asn Phe Lys Val Asp Gly Ile Leu Lys Thr Val Leu Arg Asp
1345                1350                1355                1360
Glu Ile Ile Ala Trp His Lys Lys Thr Gln Glu Asp Thr Ser Ser Pro
                1365                1370                1375    
Leu Ser Ala Ala Gly Gln Pro Glu Asn Met Asp Ser Gln Gln Leu Val
            1380                1385                1390        
Ser Leu Val Gln Lys Ala Val Thr Ala Ile Met Thr Arg Leu His Asn
        1395                1400                1405            
Leu Ala Gln Phe Glu Gly Gly Glu Ser Lys Val Asn Thr Leu Val Ala
    1410                1415                1420                
Ala Ala Asn Ser Leu Asp Asn Leu Cys Arg Met Asp Pro Ala Trp His
1425                1430                1435                1440
Pro Trp Leu
            


<210> 6540
<211> 129
<212> PRT
<213> Homo sapiens

<400> 6540
Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu
 1               5                  10                  15      
Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg
            20                  25                  30          
Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu
        35                  40                  45              
Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser
    50                  55                  60                  
Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val
65                  70                  75                  80  
Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln
                85                  90                  95      
Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His
            100                 105                 110         
Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser
        115                 120                 125             
Pro
    


<210> 6541
<211> 1615
<212> PRT
<213> Homo sapiens

<400> 6541
Met Asp Asn Leu Thr Lys Val Thr Glu Phe Leu Leu Met Glu Phe Ser
 1               5                  10                  15      
Gly Ile Trp Glu Leu Gln Val Leu His Ala Gly Leu Phe Leu Leu Ile
            20                  25                  30          
Tyr Leu Ala Val Leu Val Gly Asn Leu Leu Ile Ile Ala Val Ile Thr
        35                  40                  45              
Leu Asp Gln His Leu His Thr Pro Met Tyr Phe Phe Leu Lys Asn Leu
    50                  55                  60                  
Ser Val Leu Asp Leu Cys Tyr Ile Ser Val Thr Val Pro Lys Ser Ile
65                  70                  75                  80  
Arg Asn Ser Leu Thr Arg Arg Ser Ser Ile Ser Tyr Leu Gly Cys Val
                85                  90                  95      
Ala Gln Val Tyr Phe Phe Ser Ala Phe Ala Ser Ala Glu Leu Ala Phe
            100                 105                 110         
Leu Thr Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu
        115                 120                 125             
Gln Tyr Arg Ala Val Met Thr Ser Gly Gly Cys Tyr Gln Met Ala Val
    130                 135                 140                 
Thr Thr Trp Leu Ser Cys Phe Ser Tyr Ala Ala Val His Thr Gly Asn
145                 150                 155                 160 
Met Phe Arg Glu His Val Cys Arg Ser Ser Val Ile His Gln Phe Phe
                165                 170                 175     
Arg Asp Ile Pro His Val Leu Ala Leu Val Ser Cys Glu Val Phe Phe
            180                 185                 190         
Val Glu Phe Leu Thr Leu Ala Leu Ser Ser Cys Leu Val Leu Gly Cys
        195                 200                 205             
Phe Ile Leu Met Met Ile Ser Tyr Phe Gln Ile Phe Ser Thr Val Leu
    210                 215                 220                 
Arg Ile Pro Ser Gly Gln Ser Arg Ala Lys Ala Phe Ser Thr Cys Ser
225                 230                 235                 240 
Pro Gln Leu Ile Val Ile Met Leu Phe Leu Thr Thr Gly Leu Phe Ala
                245                 250                 255     
Ala Leu Gly Pro Ile Ala Lys Ala Leu Ser Ile Gln Asp Leu Val Ile
            260                 265                 270         
Ala Leu Thr Tyr Thr Val Leu Pro Pro Phe Leu Asn Pro Ile Ile Tyr
        275                 280                 285             
Ser Leu Arg Asn Lys Glu Ile Lys Thr Ala Met Trp Arg Leu Phe Val
    290                 295                 300                 
Lys Ile Tyr Phe Leu Gln Asn Thr Asp Ser Leu Gln Ser Ile Arg Gly
305                 310                 315                 320 
Thr Ser Gly Asp Pro Pro Ala Cys Gly Asp Ser Leu Gln Ser Leu Arg
                325                 330                 335     
Gln Met Ser Gly Asp Pro Pro Ala Ser Arg Asp Ser Leu Gln Ser Ile
            340                 345                 350         
Arg Gly Thr Ser Gly Asp Pro Pro Ala Cys Gly Asp Ser Leu Gln Ser
        355                 360                 365             
Leu Arg Arg Met Ser Gly Asp Pro Pro Ala Ser Arg Asp Ser Leu Lys
    370                 375                 380                 
Ser Leu Ser Arg Thr Ser Gly Asp Pro Pro Ala Ser Thr Asp Ser Leu
385                 390                 395                 400 
Gln Ser Ile Arg Gly Thr Ser Gly Asp Pro Pro Ala Cys Arg Asp Ser
                405                 410                 415     
Leu Gln Ser Leu Arg Trp Met Ser Gly Asp Pro Pro Ala Ser Arg Asp
            420                 425                 430         
Ser Leu Gln Ser Ile Arg Gly Thr Ser Gly Asp Pro Pro Ala Cys Gly
        435                 440                 445             
Asp Ser Leu Gln Ser Leu Arg Trp Met Ser Gly Asp Pro Pro Ala Ser
    450                 455                 460                 
Arg Asp Ser Leu Gln Ser Leu Ser Arg Thr Ser Gly Asp Pro Pro Ala
465                 470                 475                 480 
Ser Val Asp Ser Leu Gln Ser Leu Arg Gln Thr Ser Gly Asp Pro Pro
                485                 490                 495     
Ala Ser Gly Asp Ser Leu Gln Ser Leu Arg Gln Thr Ser Gly Asp Pro
            500                 505                 510         
Pro Ala Ser Thr Asp Ser Leu His Ser Leu Arg Arg Thr Ser Gly Asp
        515                 520                 525             
Pro Pro Ala Ser Ala Asp Ser Leu Gln Asn Leu Arg Trp Thr Ser Gly
    530                 535                 540                 
Asp Pro Ser Ala Ser Gly Asp Ser Leu Gln Ser Leu Arg Ala Met Glu
545                 550                 555                 560 
Gln Ser Asn Tyr Ser Val Tyr Ala Asp Phe Ile Leu Leu Gly Leu Phe
                565                 570                 575     
Ser Asn Ala Arg Phe Pro Trp Leu Leu Phe Ala Leu Ile Leu Leu Val
            580                 585                 590         
Phe Leu Thr Ser Ile Ala Ser Asn Val Val Lys Ile Ile Leu Ile His
        595                 600                 605             
Ile Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu
    610                 615                 620                 
Ser Leu Arg Asp Ile Leu Tyr Ile Ser Thr Ile Val Pro Lys Met Leu
625                 630                 635                 640 
Val Asp Gln Val Met Ser Gln Arg Ala Ile Ser Phe Ala Gly Cys Thr
                645                 650                 655     
Ala Gln His Phe Leu Tyr Leu Thr Leu Ala Gly Ala Glu Phe Phe Leu
            660                 665                 670         
Leu Gly Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu
        675                 680                 685             
His Tyr Pro Val Leu Met Ser Arg Lys Ile Cys Trp Leu Ile Val Ala
    690                 695                 700                 
Ala Ala Trp Leu Gly Gly Ser Ile Asp Gly Phe Leu Leu Thr Pro Val
705                 710                 715                 720 
Thr Met Gln Phe Pro Phe Cys Ala Ser Arg Glu Ile Asn His Phe Phe
                725                 730                 735     
Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Thr Asp Thr Ser Ala
            740                 745                 750         
Tyr Glu Thr Ala Met Tyr Val Cys Cys Ile Met Met Leu Leu Ile Pro
        755                 760                 765             
Phe Ser Val Ile Ser Gly Ser Tyr Thr Arg Ile Leu Ile Thr Val Tyr
    770                 775                 780                 
Arg Met Ser Glu Ala Glu Gly Arg Gly Lys Ala Val Ala Thr Cys Ser
785                 790                 795                 800 
Ser His Met Val Val Val Ser Leu Phe Tyr Gly Ala Ala Met Tyr Thr
                805                 810                 815     
Tyr Val Leu Pro His Ser Tyr His Thr Pro Glu Gln Asp Lys Ala Val
            820                 825                 830         
Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr
        835                 840                 845             
Ser Leu Arg Asn Lys Asp Val Thr Gly Ala Leu Gln Lys Val Val Gly
    850                 855                 860                 
Arg Met Glu Trp Lys Thr Leu Pro Phe Gln Ala Leu Gln Val Arg Cys
865                 870                 875                 880 
Val Lys Trp Arg Arg Ser Val Leu Val Ser Ser Phe Ile Ala Thr Glu
                885                 890                 895     
Arg Thr Leu Ala Asp Thr Ser His Ser Ser Ser His Ala Glu Phe Pro
            900                 905                 910         
Glu Arg Gly Val Arg Met Asn Cys Ser Lys Leu Phe Ser Leu Val Glu
        915                 920                 925             
Glu Pro Val Thr Ser Leu Gly Asp Leu Phe Asn Phe Arg Pro Arg Ser
    930                 935                 940                 
Leu Ser Trp Thr Met Gly Met Glu Gly Leu Leu Gln Asn Ser Thr Asn
945                 950                 955                 960 
Phe Val Leu Thr Gly Leu Ile Thr His Pro Ala Phe Pro Gly Leu Leu
                965                 970                 975     
Phe Ala Val Val Phe Ser Ile Phe Val Val Ala Ile Thr Ala Asn Leu
            980                 985                 990         
Val Met Ile Leu Leu Ile His Met Asp Ser Arg Leu His Thr Pro Met
        995                 1000                1005            
Tyr Phe Leu Leu Ser Gln Leu Ser Ile Met Asp Thr Ile Tyr Ile Cys
    1010                1015                1020                
Ile Thr Val Pro Lys Met Leu Gln Asp Leu Leu Ser Lys Asp Lys Thr
1025                1030                1035                1040
Ile Ser Phe Leu Gly Cys Ala Val Gln Ile Phe Tyr Leu Thr Leu Ile
                1045                1050                1055    
Gly Gly Glu Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val
            1060                1065                1070        
Ala Val Cys Asn Pro Leu Arg Tyr Pro Leu Leu Met Asn Arg Arg Val
        1075                1080                1085            
Cys Leu Phe Met Val Val Gly Ser Trp Val Gly Gly Ser Leu Asp Gly
    1090                1095                1100                
Phe Met Leu Thr Pro Val Thr Met Ser Phe Pro Phe Cys Arg Ser Arg
1105                1110                1115                1120
Glu Ile Asn His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ser
                1125                1130                1135    
Cys Thr Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ala Cys Cys Val
            1140                1145                1150        
Leu Met Leu Leu Ile Pro Leu Ser Val Ile Ser Val Ser Tyr Thr His
        1155                1160                1165            
Ile Leu Leu Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Arg Lys
    1170                1175                1180                
Ala Phe Ala Thr Cys Ser Ser His Ile Met Val Val Ser Val Phe Tyr
1185                1190                1195                1200
Gly Ala Ala Phe Tyr Thr Asn Val Leu Pro His Ser Tyr His Thr Pro
                1205                1210                1215    
Glu Lys Asp Lys Val Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met
            1220                1225                1230        
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Ala Ala
        1235                1240                1245            
Leu Arg Lys Pro Leu Ala Trp Lys Leu His Pro Asp Gly Thr Leu Arg
    1250                1255                1260                
Ser Val Thr Ser Thr Ala Asp Leu Ser His Leu Asp Arg Val Leu Leu
1265                1270                1275                1280
Pro Pro Ser Trp Ser Leu Cys Leu Pro Val Ala Leu Gly Arg Ser Trp
                1285                1290                1295    
Ala Ile Ser Met Thr Asn Thr Ser Ser Ser Asp Phe Thr Leu Leu Gly
            1300                1305                1310        
Leu Leu Val Asn Ser Glu Ala Ala Gly Ile Val Phe Thr Val Ile Leu
        1315                1320                1325            
Ala Val Phe Leu Gly Ala Val Thr Ala Asn Leu Val Met Ile Phe Leu
    1330                1335                1340                
Ile Gln Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser
1345                1350                1355                1360
Gln Leu Ser Ile Met Asp Thr Leu Phe Ile Cys Thr Thr Val Pro Lys
                1365                1370                1375    
Leu Leu Ala Asp Met Val Ser Lys Glu Lys Ile Ile Ser Phe Val Ala
            1380                1385                1390        
Cys Gly Ile Gln Ile Phe Leu Tyr Leu Thr Met Ile Gly Ser Glu Phe
        1395                1400                1405            
Phe Leu Leu Gly Leu Met Ala Tyr Asp Cys Tyr Val Ala Val Cys Asn
    1410                1415                1420                
Pro Leu Arg Tyr Pro Val Leu Met Asn Arg Lys Lys Cys Leu Leu Leu
1425                1430                1435                1440
Ala Ala Gly Ala Trp Phe Gly Gly Ser Leu Asp Gly Phe Leu Leu Thr
                1445                1450                1455    
Pro Ile Thr Met Asn Val Pro Tyr Cys Gly Ser Arg Ser Ile Asn His
            1460                1465                1470        
Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ala Cys Ala Asp Thr
        1475                1480                1485            
Ser Leu Tyr Glu Thr Leu Met Tyr Ile Cys Cys Val Leu Met Leu Leu
    1490                1495                1500                
Ile Pro Ile Ser Ile Ile Ser Thr Ser Tyr Ser Leu Ile Leu Leu Thr
1505                1510                1515                1520
Ile His Arg Met Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Thr Thr
                1525                1530                1535    
Cys Ser Ser His Leu Thr Val Val Ser Ile Phe Tyr Gly Ala Ala Phe
            1540                1545                1550        
Tyr Thr Tyr Val Leu Pro Gln Ser Phe His Thr Pro Glu Gln Asp Lys
        1555                1560                1565            
Val Val Ser Ala Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Leu
    1570                1575                1580                
Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile Gly Ala Phe Lys Lys Val
1585                1590                1595                1600
Phe Ala Cys Cys Ser Ser Ala Gln Lys Val Ala Thr Ser Asp Ala
                1605                1610                1615


<210> 6542
<211> 1717
<212> PRT
<213> Homo sapiens

<400> 6542
Met Asp Asn Leu Thr Lys Val Thr Glu Phe Leu Leu Met Glu Phe Ser
 1               5                  10                  15      
Gly Ile Trp Glu Leu Gln Val Leu His Ala Gly Leu Phe Leu Leu Ile
            20                  25                  30          
Tyr Leu Ala Val Leu Val Gly Asn Leu Leu Ile Ile Ala Val Ile Thr
        35                  40                  45              
Leu Asp Gln His Leu His Thr Pro Met Tyr Phe Phe Leu Lys Asn Leu
    50                  55                  60                  
Ser Val Leu Asp Leu Cys Tyr Ile Ser Val Thr Val Pro Lys Ser Ile
65                  70                  75                  80  
Arg Asn Ser Leu Thr Arg Arg Ser Ser Ile Ser Tyr Leu Gly Cys Val
                85                  90                  95      
Ala Gln Val Tyr Phe Phe Ser Ala Phe Ala Ser Ala Glu Leu Ala Phe
            100                 105                 110         
Leu Thr Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu
        115                 120                 125             
Gln Tyr Arg Ala Val Met Thr Ser Gly Gly Cys Tyr Gln Met Ala Val
    130                 135                 140                 
Thr Thr Trp Leu Ser Cys Phe Ser Tyr Ala Ala Val His Thr Gly Asn
145                 150                 155                 160 
Met Phe Arg Glu His Val Cys Arg Ser Ser Val Ile His Gln Phe Phe
                165                 170                 175     
Arg Asp Ile Pro His Val Leu Ala Leu Val Ser Cys Glu Val Phe Phe
            180                 185                 190         
Val Glu Phe Leu Thr Leu Ala Leu Ser Ser Cys Leu Val Leu Gly Cys
        195                 200                 205             
Phe Ile Leu Met Met Ile Ser Tyr Phe Gln Ile Phe Ser Thr Val Leu
    210                 215                 220                 
Arg Ile Pro Ser Gly Gln Ser Arg Ala Lys Ala Phe Ser Thr Cys Ser
225                 230                 235                 240 
Pro Gln Leu Ile Val Ile Met Leu Phe Leu Thr Thr Gly Leu Phe Ala
                245                 250                 255     
Ala Leu Gly Pro Ile Ala Lys Ala Leu Ser Ile Gln Asp Leu Val Ile
            260                 265                 270         
Ala Leu Thr Tyr Thr Val Leu Pro Pro Phe Leu Asn Pro Ile Ile Tyr
        275                 280                 285             
Ser Leu Arg Asn Lys Glu Ile Lys Thr Ala Met Trp Arg Leu Phe Val
    290                 295                 300                 
Lys Ile Tyr Phe Leu Gln Asn Ala Ser Val Ser Thr Pro Val Leu Ile
305                 310                 315                 320 
Phe Asn Val Leu Ile His Thr Glu Leu Phe Pro Gly Ser Glu Phe Leu
                325                 330                 335     
Val Thr Ala Gly Asp Tyr His His Arg His Cys His Tyr Phe Val Arg
            340                 345                 350         
Thr Pro Glu Arg Glu Ser Leu Gly Thr Trp Ala Val Cys His Ser Gln
        355                 360                 365             
Ser Tyr Asp Pro Asp Val Arg Glu Ala Asn Gly Pro Gly Trp Gly Lys
    370                 375                 380                 
Cys Ala Ser Phe Leu Gln Leu Leu Asp Leu Lys Phe Met Glu Val Asp
385                 390                 395                 400 
Ser Gly Pro Ala Ile Pro Asp Lys Ala Gln Met Thr Pro Val Pro Pro
                405                 410                 415     
Glu Gln Ser Ile Arg Gly Thr Ser Gly Asp Pro Pro Ala Cys Gly Asp
            420                 425                 430         
Ser Leu Gln Ser Leu Arg Gln Met Ser Gly Asp Pro Pro Ala Ser Arg
        435                 440                 445             
Asp Ser Leu Gln Ser Ile Arg Gly Thr Ser Gly Asp Pro Pro Ala Cys
    450                 455                 460                 
Gly Asp Ser Leu Gln Ser Leu Arg Arg Met Ser Gly Asp Pro Pro Ala
465                 470                 475                 480 
Ser Arg Asp Ser Leu Lys Ser Leu Ser Arg Thr Ser Gly Asp Pro Pro
                485                 490                 495     
Ala Ser Thr Asp Ser Leu Gln Ser Ile Arg Gly Thr Ser Gly Asp Pro
            500                 505                 510         
Pro Ala Cys Arg Asp Ser Leu Gln Ser Leu Arg Trp Met Ser Gly Asp
        515                 520                 525             
Pro Pro Ala Ser Arg Asp Ser Leu Gln Ser Ile Arg Gly Thr Ser Gly
    530                 535                 540                 
Asp Pro Pro Ala Cys Gly Asp Ser Leu Gln Ser Leu Arg Trp Met Ser
545                 550                 555                 560 
Gly Asp Pro Pro Ala Ser Arg Asp Ser Leu Gln Ser Leu Ser Arg Thr
                565                 570                 575     
Ser Gly Asp Pro Pro Ala Ser Val Asp Ser Leu Gln Ser Leu Arg Gln
            580                 585                 590         
Thr Ser Gly Asp Pro Pro Ala Ser Gly Asp Ser Leu Gln Ser Leu Arg
        595                 600                 605             
Gln Thr Ser Gly Asp Pro Pro Ala Ser Thr Asp Ser Leu His Ser Leu
    610                 615                 620                 
Arg Arg Thr Ser Gly Asp Pro Pro Ala Ser Ala Asp Ser Leu Gln Asn
625                 630                 635                 640 
Leu Arg Trp Thr Ser Gly Asp Pro Ser Ala Ser Gly Asp Ser Leu Gln
                645                 650                 655     
Ser Leu Arg Ala Met Glu Gln Ser Asn Tyr Ser Val Tyr Ala Asp Phe
            660                 665                 670         
Ile Leu Leu Gly Leu Phe Ser Asn Ala Arg Phe Pro Trp Leu Leu Phe
        675                 680                 685             
Ala Leu Ile Leu Leu Val Phe Leu Thr Ser Ile Ala Ser Asn Val Val
    690                 695                 700                 
Lys Ile Ile Leu Ile His Ile Asp Ser Arg Leu His Thr Pro Met Tyr
705                 710                 715                 720 
Phe Leu Leu Ser Gln Leu Ser Leu Arg Asp Ile Leu Tyr Ile Ser Thr
                725                 730                 735     
Ile Val Pro Lys Met Leu Val Asp Gln Val Met Ser Gln Arg Ala Ile
            740                 745                 750         
Ser Phe Ala Gly Cys Thr Ala Gln His Phe Leu Tyr Leu Thr Leu Ala
        755                 760                 765             
Gly Ala Glu Phe Phe Leu Leu Gly Leu Met Ser Tyr Asp Arg Tyr Val
    770                 775                 780                 
Ala Ile Cys Asn Pro Leu His Tyr Pro Val Leu Met Ser Arg Lys Ile
785                 790                 795                 800 
Cys Trp Leu Ile Val Ala Ala Ala Trp Leu Gly Gly Ser Ile Asp Gly
                805                 810                 815     
Phe Leu Leu Thr Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser Arg
            820                 825                 830         
Glu Ile Asn His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser
        835                 840                 845             
Cys Thr Asp Thr Ser Ala Tyr Glu Thr Ala Met Tyr Val Cys Cys Ile
    850                 855                 860                 
Met Met Leu Leu Ile Pro Phe Ser Val Ile Ser Gly Ser Tyr Thr Arg
865                 870                 875                 880 
Ile Leu Ile Thr Val Tyr Arg Met Ser Glu Ala Glu Gly Arg Gly Lys
                885                 890                 895     
Ala Val Ala Thr Cys Ser Ser His Met Val Val Val Ser Leu Phe Tyr
            900                 905                 910         
Gly Ala Ala Met Tyr Thr Tyr Val Leu Pro His Ser Tyr His Thr Pro
        915                 920                 925             
Glu Gln Asp Lys Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met
    930                 935                 940                 
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly Ala
945                 950                 955                 960 
Leu Gln Lys Val Val Gly Arg Met Glu Trp Lys Thr Leu Pro Phe Gln
                965                 970                 975     
Ala Leu Gln Val Arg Cys Val Lys Trp Arg Arg Ser Val Leu Val Ser
            980                 985                 990         
Ser Phe Ile Ala Thr Glu Arg Thr Leu Ala Asp Thr Ser His Ser Ser
        995                 1000                1005            
Ser His Ala Glu Phe Pro Glu Arg Gly Val Arg Met Asn Cys Ser Lys
    1010                1015                1020                
Leu Phe Ser Leu Val Glu Glu Pro Val Thr Ser Leu Gly Asp Leu Phe
1025                1030                1035                1040
Asn Phe Arg Pro Arg Ser Leu Ser Trp Thr Met Gly Met Glu Gly Leu
                1045                1050                1055    
Leu Gln Asn Ser Thr Asn Phe Val Leu Thr Gly Leu Ile Thr His Pro
            1060                1065                1070        
Ala Phe Pro Gly Leu Leu Phe Ala Val Val Phe Ser Ile Phe Val Val
        1075                1080                1085            
Ala Ile Thr Ala Asn Leu Val Met Ile Leu Leu Ile His Met Asp Ser
    1090                1095                1100                
Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Ile Met
1105                1110                1115                1120
Asp Thr Ile Tyr Ile Cys Ile Thr Val Pro Lys Met Leu Gln Asp Leu
                1125                1130                1135    
Leu Ser Lys Asp Lys Thr Ile Ser Phe Leu Gly Cys Ala Val Gln Ile
            1140                1145                1150        
Phe Tyr Leu Thr Leu Ile Gly Gly Glu Phe Phe Leu Leu Gly Leu Met
        1155                1160                1165            
Ala Tyr Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr Pro Leu
    1170                1175                1180                
Leu Met Asn Arg Arg Val Cys Leu Phe Met Val Val Gly Ser Trp Val
1185                1190                1195                1200
Gly Gly Ser Leu Asp Gly Phe Met Leu Thr Pro Val Thr Met Ser Phe
                1205                1210                1215    
Pro Phe Cys Arg Ser Arg Glu Ile Asn His Phe Phe Cys Glu Ile Pro
            1220                1225                1230        
Ala Val Leu Lys Leu Ser Cys Thr Asp Thr Ser Leu Tyr Glu Thr Leu
        1235                1240                1245            
Met Tyr Ala Cys Cys Val Leu Met Leu Leu Ile Pro Leu Ser Val Ile
    1250                1255                1260                
Ser Val Ser Tyr Thr His Ile Leu Leu Thr Val His Arg Met Asn Ser
1265                1270                1275                1280
Ala Glu Gly Arg Arg Lys Ala Phe Ala Thr Cys Ser Ser His Ile Met
                1285                1290                1295    
Val Val Ser Val Phe Tyr Gly Ala Ala Phe Tyr Thr Asn Val Leu Pro
            1300                1305                1310        
His Ser Tyr His Thr Pro Glu Lys Asp Lys Val Val Ser Ala Phe Tyr
        1315                1320                1325            
Thr Ile Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn
    1330                1335                1340                
Lys Asp Val Ala Ala Ala Leu Arg Lys Pro Leu Ala Trp Lys Leu His
1345                1350                1355                1360
Pro Asp Gly Thr Leu Arg Ser Val Thr Ser Thr Ala Asp Leu Ser His
                1365                1370                1375    
Leu Asp Arg Val Leu Leu Pro Pro Ser Trp Ser Leu Cys Leu Pro Val
            1380                1385                1390        
Ala Leu Gly Arg Ser Trp Ala Ile Ser Met Thr Asn Thr Ser Ser Ser
        1395                1400                1405            
Asp Phe Thr Leu Leu Gly Leu Leu Val Asn Ser Glu Ala Ala Gly Ile
    1410                1415                1420                
Val Phe Thr Val Ile Leu Ala Val Phe Leu Gly Ala Val Thr Ala Asn
1425                1430                1435                1440
Leu Val Met Ile Phe Leu Ile Gln Val Asp Ser Arg Leu His Thr Pro
                1445                1450                1455    
Met Tyr Phe Leu Leu Ser Gln Leu Ser Ile Met Asp Thr Leu Phe Ile
            1460                1465                1470        
Cys Thr Thr Val Pro Lys Leu Leu Ala Asp Met Val Ser Lys Glu Lys
        1475                1480                1485            
Ile Ile Ser Phe Val Ala Cys Gly Ile Gln Ile Phe Leu Tyr Leu Thr
    1490                1495                1500                
Met Ile Gly Ser Glu Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Cys
1505                1510                1515                1520
Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr Pro Val Leu Met Asn Arg
                1525                1530                1535    
Lys Lys Cys Leu Leu Leu Ala Ala Gly Ala Trp Phe Gly Gly Ser Leu
            1540                1545                1550        
Asp Gly Phe Leu Leu Thr Pro Ile Thr Met Asn Val Pro Tyr Cys Gly
        1555                1560                1565            
Ser Arg Ser Ile Asn His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys
    1570                1575                1580                
Leu Ala Cys Ala Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ile Cys
1585                1590                1595                1600
Cys Val Leu Met Leu Leu Ile Pro Ile Ser Ile Ile Ser Thr Ser Tyr
                1605                1610                1615    
Ser Leu Ile Leu Leu Thr Ile His Arg Met Pro Ser Ala Glu Gly Arg
            1620                1625                1630        
Lys Lys Ala Phe Thr Thr Cys Ser Ser His Leu Thr Val Val Ser Ile
        1635                1640                1645            
Phe Tyr Gly Ala Ala Phe Tyr Thr Tyr Val Leu Pro Gln Ser Phe His
    1650                1655                1660                
Thr Pro Glu Gln Asp Lys Val Val Ser Ala Phe Tyr Thr Ile Val Thr
1665                1670                1675                1680
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile
                1685                1690                1695    
Gly Ala Phe Lys Lys Val Phe Ala Cys Cys Ser Ser Ala Gln Lys Val
            1700                1705                1710        
Ala Thr Ser Asp Ala
        1715        


<210> 6543
<211> 735
<212> PRT
<213> Homo sapiens

<400> 6543
Met Phe Tyr Val Asn Gln Ile Pro Phe Gln Leu Tyr His Ile Ser Phe
 1               5                  10                  15      
Val Tyr Pro Thr Glu Leu Trp Ser Arg Ala Ile Ile Pro Cys Met Pro
            20                  25                  30          
Thr Leu Ser Phe Trp Val Cys Ser Ala Thr Pro Val Ser Pro Gly Phe
        35                  40                  45              
Phe Ala Leu Ile Leu Leu Val Phe Val Thr Ser Ile Ala Ser Asn Val
    50                  55                  60                  
Val Lys Ile Ile Leu Ile His Ile Asp Ser Arg Leu His Thr Pro Met
65                  70                  75                  80  
Tyr Phe Leu Leu Ser Gln Leu Ser Leu Arg Asp Ile Leu Tyr Ile Ser
                85                  90                  95      
Thr Ile Val Pro Lys Met Leu Val Asp Gln Val Met Ser Gln Arg Ala
            100                 105                 110         
Ile Ser Phe Ala Gly Cys Thr Ala Gln His Phe Leu Tyr Leu Thr Leu
        115                 120                 125             
Ala Gly Ala Glu Phe Phe Leu Leu Gly Leu Met Ser Cys Asp Arg Tyr
    130                 135                 140                 
Val Ala Ile Cys Asn Pro Leu His Tyr Pro Asp Leu Met Ser Arg Lys
145                 150                 155                 160 
Ile Cys Trp Leu Ile Val Ala Ala Ala Trp Leu Gly Gly Ser Ile Asp
                165                 170                 175     
Gly Phe Leu Leu Thr Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser
            180                 185                 190         
Arg Glu Ile Asn His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu
        195                 200                 205             
Ser Cys Thr Asp Thr Ser Ala Tyr Glu Thr Ala Met Tyr Val Cys Cys
    210                 215                 220                 
Ile Met Met Leu Leu Ile Pro Phe Ser Val Ile Ser Gly Ser Tyr Thr
225                 230                 235                 240 
Arg Ile Leu Ile Thr Val Tyr Arg Met Ser Glu Ala Glu Gly Arg Arg
                245                 250                 255     
Lys Ala Val Ala Thr Cys Ser Ser His Met Val Val Val Ser Leu Phe
            260                 265                 270         
Tyr Gly Ala Ala Met Tyr Thr Tyr Val Leu Pro His Ser Tyr His Thr
        275                 280                 285             
Pro Glu Gln Asp Lys Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro
    290                 295                 300                 
Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly
305                 310                 315                 320 
Ala Leu Gln Lys Val Val Gly Arg Met Glu Trp Lys Thr Leu Pro Phe
                325                 330                 335     
Gln Ala Leu Gln Val Arg Cys Val Lys Trp Arg Arg Ser Val Leu Val
            340                 345                 350         
Ser Ser Phe Ile Ala Thr Glu Arg Thr Leu Ala Asp Thr Ser His Ser
        355                 360                 365             
Ser Ser His Ala Glu Phe Pro Glu Arg Gly Val Arg Met Asn Cys Ser
    370                 375                 380                 
Lys Leu Phe Ser Leu Val Glu Glu Pro Val Thr Ser Leu Gly Asp Leu
385                 390                 395                 400 
Phe Asn Phe Arg Pro Arg Ser Leu Ser Trp Thr Met Gly Met Glu Gly
                405                 410                 415     
Leu Leu Gln Asn Ser Thr Asn Phe Val Leu Thr Gly Leu Ile Thr His
            420                 425                 430         
Pro Ala Phe Pro Gly Leu Leu Phe Ala Ile Val Phe Ser Ile Phe Val
        435                 440                 445             
Val Ala Ile Thr Ala Asn Leu Val Met Ile Leu Leu Ile His Met Asp
    450                 455                 460                 
Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Ile
465                 470                 475                 480 
Met Asp Thr Ile Tyr Ile Cys Ile Thr Val Pro Lys Met Leu Gln Asp
                485                 490                 495     
Leu Leu Ser Lys Asp Lys Thr Ile Ser Phe Leu Gly Cys Ala Val Gln
            500                 505                 510         
Ile Phe Leu Tyr Leu Thr Leu Ile Gly Gly Glu Phe Phe Leu Leu Gly
        515                 520                 525             
Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr
    530                 535                 540                 
Pro Leu Leu Met Asn Arg Arg Val Cys Leu Phe Met Val Val Gly Ser
545                 550                 555                 560 
Trp Val Gly Gly Ser Leu Asp Gly Phe Met Leu Thr Pro Val Thr Met
                565                 570                 575     
Ser Phe Pro Phe Cys Arg Ser Arg Glu Ile Asn His Phe Phe Cys Glu
            580                 585                 590         
Ile Pro Ala Val Leu Lys Leu Ser Cys Thr Asp Thr Ser Leu Tyr Glu
        595                 600                 605             
Thr Leu Met Tyr Ala Cys Cys Val Leu Met Leu Leu Ile Pro Leu Ser
    610                 615                 620                 
Val Ile Ser Val Ser Tyr Thr His Ile Leu Leu Thr Val His Arg Met
625                 630                 635                 640 
Asn Ser Ala Glu Gly Arg Arg Lys Ala Phe Ala Thr Cys Ser Ser His
                645                 650                 655     
Ile Met Val Val Ser Val Phe Tyr Gly Ala Ala Phe Tyr Thr Asn Val
            660                 665                 670         
Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp Lys Val Val Ser Ala
        675                 680                 685             
Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu
    690                 695                 700                 
Arg Asn Lys Asp Val Ala Ala Ala Leu Arg Lys Val Leu Gly Arg Cys
705                 710                 715                 720 
Gly Ser Ser Gln Ser Ile Arg Val Ala Thr Val Ile Arg Lys Gly
                725                 730                 735 


<210> 6544
<211> 312
<212> PRT
<213> Homo sapiens

<400> 6544
Met Glu Asn Gly Ser Tyr Thr Ser Tyr Phe Ile Leu Leu Gly Leu Phe
 1               5                  10                  15      
Asn His Thr Arg Ala His Gln Val Leu Phe Met Met Val Leu Ser Ile
            20                  25                  30          
Val Leu Thr Ser Leu Phe Gly Asn Ser Leu Met Ile Leu Leu Ile His
        35                  40                  45              
Trp Asp His Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu
    50                  55                  60                  
Ser Leu Met Asp Val Met Leu Val Ser Thr Thr Val Pro Lys Met Ala
65                  70                  75                  80  
Ala Asp Tyr Leu Thr Gly Ser Lys Ala Ile Ser Arg Ala Gly Cys Gly
                85                  90                  95      
Ala Gln Ile Phe Phe Leu Pro Thr Leu Gly Gly Gly Glu Cys Phe Leu
            100                 105                 110         
Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys His Pro Leu
        115                 120                 125             
Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu Cys Leu Arg Met Asn Leu
    130                 135                 140                 
Ser Cys Trp Leu Leu Gly Ala Ala Asp Gly Leu Leu Gln Ala Val Ala
145                 150                 155                 160 
Thr Leu Ser Phe Pro Tyr Cys Gly Ala His Glu Ile Asp His Phe Phe
                165                 170                 175     
Cys Glu Thr Pro Val Leu Val Arg Leu Ala Cys Ala Asp Thr Ser Val
            180                 185                 190         
Phe Glu Asn Ala Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro
        195                 200                 205             
Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu Ile Leu Ala Ala Val Leu
    210                 215                 220                 
His Met Arg Ser Thr Glu Ala Arg Lys Lys Ala Phe Ala Thr Cys Ser
225                 230                 235                 240 
Ser His Val Ala Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Thr
                245                 250                 255     
Tyr Met Arg Pro Lys Ser His Arg Ser Thr Asn His Asp Lys Val Val
            260                 265                 270         
Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr
        275                 280                 285             
Ser Val Lys Asn Ser Glu Val Lys Gly Ala Leu Thr Arg Cys Met Gly
    290                 295                 300                 
Arg Cys Val Ala Leu Ser Arg Glu
305                 310         


<210> 6545
<211> 678
<212> PRT
<213> Homo sapiens

<400> 6545
Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala
 1               5                  10                  15      
Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser
            20                  25                  30          
Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu
        35                  40                  45              
Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln
    50                  55                  60                  
Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg
65                  70                  75                  80  
Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly
                85                  90                  95      
Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu
            100                 105                 110         
Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met
        115                 120                 125             
Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu
    130                 135                 140                 
Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys
145                 150                 155                 160 
Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu
                165                 170                 175     
Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly
            180                 185                 190         
Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser
        195                 200                 205             
Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg
    210                 215                 220                 
Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe
225                 230                 235                 240 
Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val
                245                 250                 255     
Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr
            260                 265                 270         
Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr
        275                 280                 285             
Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu
    290                 295                 300                 
Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn
305                 310                 315                 320 
Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln
                325                 330                 335     
Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp
            340                 345                 350         
His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp
        355                 360                 365             
His Arg Pro Ser Glu Glu Val Lys Gln Thr Lys Arg Leu Lys Gly Leu
    370                 375                 380                 
Arg Lys Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala Ser
385                 390                 395                 400 
Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser Ile
                405                 410                 415     
Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His Ile Gly
            420                 425                 430         
Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala
        435                 440                 445             
Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe
    450                 455                 460                 
Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu
465                 470                 475                 480 
Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys
                485                 490                 495     
Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile Met
            500                 505                 510         
Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser Gln Pro
        515                 520                 525             
Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr
    530                 535                 540                 
Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser Thr
545                 550                 555                 560 
Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val
                565                 570                 575     
Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr
            580                 585                 590         
Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly
        595                 600                 605             
Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys Asp
    610                 615                 620                 
Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg Glu
625                 630                 635                 640 
Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val Leu Gly
                645                 650                 655     
Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu Arg Tyr
            660                 665                 670         
Lys Ile Arg Ala Glu Arg
        675             


<210> 6546
<211> 666
<212> PRT
<213> Homo sapiens

<400> 6546
Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala
 1               5                  10                  15      
Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser
            20                  25                  30          
Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu
        35                  40                  45              
Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln
    50                  55                  60                  
Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg
65                  70                  75                  80  
Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly
                85                  90                  95      
Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu
            100                 105                 110         
Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met
        115                 120                 125             
Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu
    130                 135                 140                 
Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys
145                 150                 155                 160 
Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu
                165                 170                 175     
Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly
            180                 185                 190         
Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser
        195                 200                 205             
Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg
    210                 215                 220                 
Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe
225                 230                 235                 240 
Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val
                245                 250                 255     
Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr
            260                 265                 270         
Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr
        275                 280                 285             
Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu
    290                 295                 300                 
Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn
305                 310                 315                 320 
Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln
                325                 330                 335     
Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp
            340                 345                 350         
His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp
        355                 360                 365             
His Arg Pro Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys His Ser
    370                 375                 380                 
Phe Ser Ala Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr
385                 390                 395                 400 
Phe Leu Ser Ile Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr
                405                 410                 415     
Ser His Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile
            420                 425                 430         
Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe
        435                 440                 445             
Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr
    450                 455                 460                 
Phe Pro Leu Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp
465                 470                 475                 480 
Tyr Ser Leu Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro
                485                 490                 495     
Phe Gln Ile Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met
            500                 505                 510         
Thr Ser Gln Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu
        515                 520                 525             
Gly Thr Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly
    530                 535                 540                 
Ala Ala Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr
545                 550                 555                 560 
Ala Ile Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr
                565                 570                 575     
Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr
            580                 585                 590         
Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp
        595                 600                 605             
Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala
    610                 615                 620                 
Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe
625                 630                 635                 640 
Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe
                645                 650                 655     
Val Leu Arg Tyr Lys Ile Arg Ala Glu Arg
            660                 665     


<210> 6547
<211> 298
<212> PRT
<213> Homo sapiens

<400> 6547
Met Lys Thr Leu Gln Ser Thr Leu Leu Leu Leu Leu Leu Val Pro Leu
 1               5                  10                  15      
Ile Lys Pro Ala Pro Pro Thr Gln Gln Asp Ser Arg Ile Ile Tyr Asp
            20                  25                  30          
Tyr Gly Thr Asp Asn Phe Glu Glu Ser Ile Phe Ser Gln Asp Tyr Glu
        35                  40                  45              
Asp Lys Tyr Leu Asp Gly Lys Asn Ile Lys Glu Lys Glu Thr Val Ile
    50                  55                  60                  
Ile Pro Asn Glu Lys Ser Leu Gln Leu Gln Lys Asp Glu Ala Ile Thr
65                  70                  75                  80  
Pro Leu Pro Pro Lys Lys Glu Asn Asp Glu Met Pro Thr Cys Leu Leu
                85                  90                  95      
Cys Val Cys Leu Ser Gly Ser Val Tyr Cys Glu Glu Val Asp Ile Asp
            100                 105                 110         
Ala Val Pro Pro Leu Pro Lys Glu Ser Ala Tyr Leu Tyr Ala Arg Phe
        115                 120                 125             
Asn Lys Ile Lys Lys Leu Thr Ala Lys Asp Phe Ala Asp Ile Pro Asn
    130                 135                 140                 
Leu Arg Arg Leu Asp Phe Thr Gly Asn Leu Ile Glu Asp Ile Glu Asp
145                 150                 155                 160 
Gly Thr Phe Ser Lys Leu Ser Leu Leu Glu Glu Leu Ser Leu Ala Glu
                165                 170                 175     
Asn Gln Leu Leu Lys Leu Pro Val Leu Pro Pro Lys Leu Thr Leu Phe
            180                 185                 190         
Asn Ala Lys Tyr Asn Lys Ile Lys Ser Arg Gly Ile Lys Ala Asn Ala
        195                 200                 205             
Phe Lys Lys Leu Asn Asn Leu Thr Phe Leu Tyr Leu Asp His Asn Ala
    210                 215                 220                 
Leu Glu Ser Val Pro Leu Asn Leu Pro Glu Ser Leu Arg Val Ile His
225                 230                 235                 240 
Leu Gln Phe Asn Asn Ile Ala Ser Ile Thr Asp Asp Thr Phe Cys Lys
                245                 250                 255     
Ala Asn Asp Thr Ser Tyr Ile Arg Asp Arg Ile Glu Glu Ile Arg Leu
            260                 265                 270         
Glu Gly Asn Pro Ile Val Leu Gly Lys His Pro Asn Ser Phe Ile Cys
        275                 280                 285             
Leu Lys Arg Leu Pro Ile Gly Ser Tyr Phe
    290                 295             


<210> 6548
<211> 333
<212> PRT
<213> Homo sapiens

<400> 6548
Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp
            20                  25                  30          
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr
            100                 105                 110         
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
        195                 200                 205             
Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                245                 250                 255     
Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
            260                 265                 270         
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
        275                 280                 285             
Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
    290                 295                 300                 
Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
305                 310                 315                 320 
His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                325                 330             


<210> 6549
<211> 583
<212> PRT
<213> Homo sapiens

<400> 6549
Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu
 1               5                  10                  15      
Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn
            20                  25                  30          
Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro
        35                  40                  45              
Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser
    50                  55                  60                  
Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr
65                  70                  75                  80  
Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr
                85                  90                  95      
Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val
            100                 105                 110         
Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val
        115                 120                 125             
Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu
    130                 135                 140                 
Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu
145                 150                 155                 160 
Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val
                165                 170                 175     
Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met
            180                 185                 190         
Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys
        195                 200                 205             
Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr
    210                 215                 220                 
Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe
225                 230                 235                 240 
Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro
                245                 250                 255     
Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly
            260                 265                 270         
Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln
        275                 280                 285             
Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Met Asp Val Arg
    290                 295                 300                 
Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser
305                 310                 315                 320 
Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu
                325                 330                 335     
Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val
            340                 345                 350         
Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys
        355                 360                 365             
Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr
    370                 375                 380                 
Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu
385                 390                 395                 400 
Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro
                405                 410                 415     
Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr
            420                 425                 430         
Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr
        435                 440                 445             
Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr
    450                 455                 460                 
Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn
465                 470                 475                 480 
Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn
                485                 490                 495     
Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp
            500                 505                 510         
Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu
        515                 520                 525             
Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly
    530                 535                 540                 
Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His
545                 550                 555                 560 
Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu
                565                 570                 575     
Asn Asn His Lys Thr Glu Ala
            580             


<210> 6550
<211> 3122
<212> PRT
<213> Homo sapiens

<400> 6550
Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly
 1               5                  10                  15      
Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln
            20                  25                  30          
Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser
        35                  40                  45              
Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu
    50                  55                  60                  
Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn
65                  70                  75                  80  
Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg
                85                  90                  95      
His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser
            100                 105                 110         
Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu
        115                 120                 125             
Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala
    130                 135                 140                 
Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp
145                 150                 155                 160 
Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys
                165                 170                 175     
Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala
            180                 185                 190         
Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro
        195                 200                 205             
Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser
    210                 215                 220                 
Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr
225                 230                 235                 240 
Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met
                245                 250                 255     
Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg
            260                 265                 270         
Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile
        275                 280                 285             
Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys
    290                 295                 300                 
Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln
305                 310                 315                 320 
Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu
                325                 330                 335     
Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu
            340                 345                 350         
Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile
        355                 360                 365             
Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn
    370                 375                 380                 
Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro
385                 390                 395                 400 
Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys
                405                 410                 415     
Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His
            420                 425                 430         
Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe
        435                 440                 445             
Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro
    450                 455                 460                 
Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp
465                 470                 475                 480 
Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp
                485                 490                 495     
Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp
            500                 505                 510         
Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln
        515                 520                 525             
Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr
    530                 535                 540                 
Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp
545                 550                 555                 560 
Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln
                565                 570                 575     
Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly
            580                 585                 590         
Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr
        595                 600                 605             
Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met
    610                 615                 620                 
Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu
625                 630                 635                 640 
Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys
                645                 650                 655     
Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys
            660                 665                 670         
Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile
        675                 680                 685             
Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn
    690                 695                 700                 
Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala
705                 710                 715                 720 
Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu
                725                 730                 735     
Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly
            740                 745                 750         
Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp
        755                 760                 765             
Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr
    770                 775                 780                 
Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr
785                 790                 795                 800 
Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn
                805                 810                 815     
Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys
            820                 825                 830         
Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala
        835                 840                 845             
Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro
    850                 855                 860                 
Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp
865                 870                 875                 880 
Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg
                885                 890                 895     
Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala
            900                 905                 910         
Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu
        915                 920                 925             
Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln
    930                 935                 940                 
Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser
945                 950                 955                 960 
Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser
                965                 970                 975     
Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr
            980                 985                 990         
Gly Lys Lys Cys Asp Arg Cys Ala His Gly Tyr Phe Asn Phe Gln Glu
        995                 1000                1005            
Gly Gly Cys Thr Ala Cys Glu Cys Ser His Leu Gly Asn Asn Cys Asp
    1010                1015                1020                
Pro Lys Thr Gly Arg Cys Ile Cys Pro Pro Asn Thr Ile Gly Glu Lys
1025                1030                1035                1040
Cys Ser Lys Cys Ala Pro Asn Thr Trp Gly His Ser Ile Thr Thr Gly
                1045                1050                1055    
Cys Lys Ala Cys Asn Cys Ser Thr Val Gly Ser Leu Asp Phe Gln Cys
            1060                1065                1070        
Asn Val Asn Thr Gly Gln Cys Asn Cys His Pro Lys Phe Ser Gly Ala
        1075                1080                1085            
Lys Cys Thr Glu Cys Ser Arg Gly His Trp Asn Tyr Pro Arg Cys Asn
    1090                1095                1100                
Leu Cys Asp Cys Phe Leu Pro Gly Thr Asp Ala Thr Thr Cys Asp Ser
1105                1110                1115                1120
Glu Thr Lys Lys Cys Ser Cys Ser Asp Gln Thr Gly Gln Cys Thr Cys
                1125                1130                1135    
Lys Val Asn Val Glu Gly Ile His Cys Asp Arg Cys Arg Pro Gly Lys
            1140                1145                1150        
Phe Gly Leu Asp Ala Lys Asn Pro Leu Gly Cys Ser Ser Cys Tyr Cys
        1155                1160                1165            
Phe Gly Thr Thr Thr Gln Cys Ser Glu Ala Lys Gly Leu Ile Arg Thr
    1170                1175                1180                
Trp Val Thr Leu Lys Ala Glu Gln Thr Ile Leu Pro Leu Val Asp Glu
1185                1190                1195                1200
Ala Leu Gln His Thr Thr Thr Lys Gly Ile Val Phe Gln His Pro Glu
                1205                1210                1215    
Ile Val Ala His Met Asp Leu Met Arg Glu Asp Leu His Leu Glu Pro
            1220                1225                1230        
Phe Tyr Trp Lys Leu Pro Glu Gln Phe Glu Gly Lys Lys Leu Met Ala
        1235                1240                1245            
Tyr Gly Gly Lys Leu Lys Tyr Ala Ile Tyr Phe Glu Ala Arg Glu Glu
    1250                1255                1260                
Thr Gly Phe Ser Thr Tyr Asn Pro Gln Val Ile Ile Arg Gly Gly Thr
1265                1270                1275                1280
Pro Thr His Ala Arg Ile Ile Val Arg His Met Ala Ala Pro Leu Ile
                1285                1290                1295    
Gly Gln Leu Thr Arg His Glu Ile Glu Met Thr Glu Lys Glu Trp Lys
            1300                1305                1310        
Tyr Tyr Gly Asp Asp Pro Arg Val His Arg Thr Val Thr Arg Glu Asp
        1315                1320                1325            
Phe Leu Asp Ile Leu Tyr Asp Ile His Tyr Ile Leu Ile Lys Ala Thr
    1330                1335                1340                
Tyr Gly Asn Phe Met Arg Gln Ser Arg Ile Ser Glu Ile Ser Met Glu
1345                1350                1355                1360
Val Ala Glu Gln Gly Arg Gly Thr Thr Met Thr Pro Pro Ala Asp Leu
                1365                1370                1375    
Ile Glu Lys Cys Asp Cys Pro Leu Gly Tyr Ser Gly Leu Ser Cys Glu
            1380                1385                1390        
Ala Cys Leu Pro Gly Phe Tyr Arg Leu Arg Ser Gln Pro Gly Gly Arg
        1395                1400                1405            
Thr Pro Gly Pro Thr Leu Gly Thr Cys Val Pro Cys Gln Cys Asn Gly
    1410                1415                1420                
His Ser Ser Leu Cys Asp Pro Glu Thr Ser Ile Cys Gln Asn Cys Gln
1425                1430                1435                1440
His His Thr Ala Gly Asp Phe Cys Glu Arg Cys Ala Leu Gly Tyr Tyr
                1445                1450                1455    
Gly Ile Val Lys Gly Leu Pro Asn Asp Cys Gln Gln Cys Ala Cys Pro
            1460                1465                1470        
Leu Ile Ser Ser Ser Asn Asn Phe Ser Pro Ser Cys Val Ala Glu Gly
        1475                1480                1485            
Leu Asp Asp Tyr Arg Cys Thr Ala Cys Pro Arg Gly Tyr Glu Gly Gln
    1490                1495                1500                
Tyr Cys Glu Arg Cys Ala Pro Gly Tyr Thr Gly Ser Pro Gly Asn Pro
1505                1510                1515                1520
Gly Gly Ser Cys Gln Glu Cys Glu Cys Asp Pro Tyr Gly Ser Leu Pro
                1525                1530                1535    
Val Pro Cys Asp Pro Val Thr Gly Phe Cys Thr Cys Arg Pro Gly Ala
            1540                1545                1550        
Thr Gly Arg Lys Cys Asp Gly Cys Lys His Trp His Ala Arg Glu Gly
        1555                1560                1565            
Trp Glu Cys Val Phe Cys Gly Asp Glu Cys Thr Gly Leu Leu Leu Gly
    1570                1575                1580                
Asp Leu Ala Arg Leu Glu Gln Met Val Met Ser Ile Asn Leu Thr Gly
1585                1590                1595                1600
Pro Leu Pro Ala Pro Tyr Lys Met Leu Tyr Gly Leu Glu Asn Met Thr
                1605                1610                1615    
Gln Glu Leu Lys His Leu Leu Ser Pro Gln Arg Ala Pro Glu Arg Leu
            1620                1625                1630        
Ile Gln Leu Ala Glu Gly Asn Leu Asn Thr Leu Val Thr Glu Met Asn
        1635                1640                1645            
Glu Leu Leu Thr Arg Ala Thr Lys Val Thr Ala Asp Gly Glu Gln Thr
    1650                1655                1660                
Gly Gln Asp Ala Glu Arg Thr Asn Thr Arg Ala Lys Ser Leu Gly Glu
1665                1670                1675                1680
Phe Ile Lys Glu Leu Ala Arg Asp Ala Glu Ala Val Asn Glu Lys Ala
                1685                1690                1695    
Ile Lys Leu Asn Glu Thr Leu Gly Thr Arg Asp Glu Ala Phe Glu Arg
            1700                1705                1710        
Asn Leu Glu Gly Leu Gln Lys Glu Ile Asp Gln Met Ile Lys Glu Leu
        1715                1720                1725            
Arg Arg Lys Asn Leu Glu Thr Gln Lys Glu Ile Ala Glu Asp Glu Leu
    1730                1735                1740                
Val Ala Ala Glu Ala Leu Leu Lys Lys Val Lys Lys Leu Phe Gly Glu
1745                1750                1755                1760
Ser Arg Gly Glu Asn Glu Glu Met Glu Lys Asp Leu Arg Glu Lys Leu
                1765                1770                1775    
Ala Asp Tyr Lys Asn Lys Val Asp Asp Ala Trp Asp Leu Leu Arg Glu
            1780                1785                1790        
Ala Thr Asp Lys Ile Arg Glu Ala Asn Arg Leu Phe Ala Val Asn Gln
        1795                1800                1805            
Lys Asn Met Thr Ala Leu Glu Lys Lys Lys Glu Ala Val Glu Ser Gly
    1810                1815                1820                
Lys Arg Gln Ile Glu Asn Thr Leu Lys Glu Gly Asn Asp Ile Leu Asp
1825                1830                1835                1840
Glu Ala Asn Arg Leu Ala Asp Glu Ile Asn Ser Ile Ile Asp Tyr Val
                1845                1850                1855    
Glu Asp Ile Gln Thr Lys Leu Pro Pro Met Ser Glu Glu Leu Asn Asp
            1860                1865                1870        
Lys Ile Asp Asp Leu Ser Gln Glu Ile Lys Asp Arg Lys Leu Ala Glu
        1875                1880                1885            
Lys Val Ser Gln Ala Glu Ser His Ala Ala Gln Leu Asn Asp Ser Ser
    1890                1895                1900                
Ala Val Leu Asp Gly Ile Leu Asp Glu Ala Lys Asn Ile Ser Phe Asn
1905                1910                1915                1920
Ala Thr Ala Ala Phe Lys Ala Tyr Ser Asn Ile Lys Asp Tyr Ile Asp
                1925                1930                1935    
Glu Ala Glu Lys Val Ala Lys Glu Ala Lys Asp Leu Ala His Glu Ala
            1940                1945                1950        
Thr Lys Leu Ala Thr Gly Pro Arg Gly Leu Leu Lys Glu Asp Ala Lys
        1955                1960                1965            
Gly Cys Leu Gln Lys Ser Phe Arg Ile Leu Asn Glu Ala Lys Lys Leu
    1970                1975                1980                
Ala Asn Asp Val Lys Glu Asn Glu Asp His Leu Asn Gly Leu Lys Thr
1985                1990                1995                2000
Arg Ile Glu Asn Ala Asp Ala Arg Asn Gly Asp Leu Leu Arg Thr Leu
                2005                2010                2015    
Asn Asp Thr Leu Gly Lys Leu Ser Ala Ile Pro Asn Asp Thr Ala Ala
            2020                2025                2030        
Lys Leu Gln Ala Val Lys Asp Lys Ala Arg Gln Ala Asn Asp Thr Ala
        2035                2040                2045            
Lys Asp Val Leu Ala Gln Ile Thr Glu Leu His Gln Asn Leu Asp Gly
    2050                2055                2060                
Leu Lys Lys Asn Tyr Asn Lys Leu Ala Asp Ser Val Ala Lys Thr Asn
2065                2070                2075                2080
Ala Val Val Lys Asp Pro Ser Lys Asn Lys Ile Ile Ala Asp Ala Asp
                2085                2090                2095    
Ala Thr Val Lys Asn Leu Glu Gln Glu Ala Asp Arg Leu Ile Asp Lys
            2100                2105                2110        
Leu Lys Pro Ile Lys Glu Leu Glu Asp Asn Leu Lys Lys Asn Ile Ser
        2115                2120                2125            
Glu Ile Lys Glu Leu Ile Asn Gln Ala Arg Lys Gln Ala Asn Ser Ile
    2130                2135                2140                
Lys Val Ser Val Ser Ser Gly Gly Asp Cys Ile Arg Thr Tyr Lys Pro
2145                2150                2155                2160
Glu Ile Lys Lys Gly Ser Tyr Asn Asn Ile Val Val Asn Val Lys Thr
                2165                2170                2175    
Ala Val Ala Asp Asn Leu Leu Phe Tyr Leu Gly Ser Ala Lys Phe Ile
            2180                2185                2190        
Asp Phe Leu Ala Ile Glu Met Arg Lys Gly Lys Val Ser Phe Leu Trp
        2195                2200                2205            
Asp Val Gly Ser Gly Val Gly Arg Val Glu Tyr Pro Asp Leu Thr Ile
    2210                2215                2220                
Asp Asp Ser Tyr Trp Tyr Arg Ile Val Ala Ser Arg Thr Gly Arg Asn
2225                2230                2235                2240
Gly Thr Ile Ser Val Arg Ala Leu Asp Gly Pro Lys Ala Ser Ile Val
                2245                2250                2255    
Pro Ser Thr His His Ser Thr Ser Pro Pro Gly Tyr Thr Ile Leu Asp
            2260                2265                2270        
Val Asp Ala Asn Ala Met Leu Phe Val Gly Gly Leu Thr Gly Lys Leu
        2275                2280                2285            
Lys Lys Ala Asp Ala Val Arg Val Ile Thr Phe Thr Gly Cys Met Gly
    2290                2295                2300                
Glu Thr Tyr Phe Asp Asn Lys Pro Ile Gly Leu Trp Asn Phe Arg Glu
2305                2310                2315                2320
Lys Glu Gly Asp Cys Lys Gly Cys Thr Val Ser Pro Gln Val Glu Asp
                2325                2330                2335    
Ser Glu Gly Thr Ile Gln Phe Asp Gly Glu Gly Tyr Ala Leu Val Ser
            2340                2345                2350        
Arg Pro Ile Arg Trp Tyr Pro Asn Ile Ser Thr Val Met Phe Lys Phe
        2355                2360                2365            
Arg Thr Phe Ser Ser Ser Ala Leu Leu Met Tyr Leu Ala Thr Arg Asp
    2370                2375                2380                
Leu Arg Asp Phe Met Ser Val Glu Leu Thr Asp Gly His Ile Lys Val
2385                2390                2395                2400
Ser Tyr Asp Leu Gly Ser Gly Met Ala Ser Val Val Ser Asn Gln Asn
                2405                2410                2415    
His Asn Asp Gly Lys Trp Lys Ser Phe Thr Leu Ser Arg Ile Gln Lys
            2420                2425                2430        
Gln Ala Asn Ile Ser Ile Val Asp Ile Asp Thr Asn Gln Glu Glu Asn
        2435                2440                2445            
Ile Ala Thr Ser Ser Ser Gly Asn Asn Phe Gly Leu Asp Leu Lys Ala
    2450                2455                2460                
Asp Asp Lys Ile Tyr Phe Gly Gly Leu Pro Thr Leu Arg Asn Leu Ser
2465                2470                2475                2480
Met Lys Ala Arg Pro Glu Val Asn Leu Lys Lys Tyr Ser Gly Cys Leu
                2485                2490                2495    
Lys Asp Ile Glu Ile Ser Arg Thr Pro Tyr Asn Ile Leu Ser Ser Pro
            2500                2505                2510        
Asp Tyr Val Gly Val Thr Lys Gly Cys Ser Leu Glu Asn Val Tyr Thr
        2515                2520                2525            
Val Ser Phe Pro Lys Pro Gly Phe Val Glu Leu Ser Pro Val Pro Ile
    2530                2535                2540                
Asp Val Gly Thr Glu Ile Asn Leu Ser Phe Ser Thr Lys Asn Glu Ser
2545                2550                2555                2560
Gly Ile Ile Leu Leu Gly Ser Gly Gly Thr Pro Ala Pro Pro Arg Arg
                2565                2570                2575    
Lys Arg Arg Gln Thr Gly Gln Ala Tyr Tyr Val Ile Leu Leu Asn Arg
            2580                2585                2590        
Gly Arg Leu Glu Val His Leu Ser Thr Gly Ala Arg Thr Met Arg Lys
        2595                2600                2605            
Ile Val Ile Arg Pro Glu Pro Asn Leu Phe His Asp Gly Arg Glu His
    2610                2615                2620                
Ser Val His Val Glu Arg Thr Arg Gly Ile Phe Thr Val Gln Val Asp
2625                2630                2635                2640
Glu Asn Arg Arg Tyr Met Gln Asn Leu Thr Val Glu Gln Pro Ile Glu
                2645                2650                2655    
Val Lys Lys Leu Phe Val Gly Gly Ala Pro Pro Glu Phe Gln Pro Ser
            2660                2665                2670        
Pro Leu Arg Asn Ile Pro Pro Phe Glu Gly Cys Ile Trp Asn Leu Val
        2675                2680                2685            
Ile Asn Ser Val Pro Met Asp Phe Ala Arg Pro Val Ser Phe Lys Asn
    2690                2695                2700                
Ala Asp Ile Gly Arg Cys Ala His Gln Lys Leu Arg Glu Asp Glu Asp
2705                2710                2715                2720
Gly Ala Ala Pro Ala Glu Ile Val Ile Gln Pro Glu Pro Val Pro Thr
                2725                2730                2735    
Pro Ala Phe Pro Thr Pro Thr Pro Val Leu Thr His Gly Pro Cys Ala
            2740                2745                2750        
Ala Glu Ser Glu Pro Ala Leu Leu Ile Gly Ser Lys Gln Phe Gly Leu
        2755                2760                2765            
Ser Arg Asn Ser His Ile Ala Ile Ala Phe Asp Asp Thr Lys Val Lys
    2770                2775                2780                
Asn Arg Leu Thr Ile Glu Leu Glu Val Arg Thr Glu Ala Glu Ser Gly
2785                2790                2795                2800
Leu Leu Phe Tyr Met Ala Arg Ile Asn His Ala Asp Phe Ala Thr Val
                2805                2810                2815    
Gln Leu Arg Asn Gly Leu Pro Tyr Phe Ser Tyr Asp Leu Gly Ser Gly
            2820                2825                2830        
Asp Thr His Thr Met Ile Pro Thr Lys Ile Asn Asp Gly Gln Trp His
        2835                2840                2845            
Lys Ile Lys Ile Met Arg Ser Lys Gln Glu Gly Ile Leu Tyr Val Asp
    2850                2855                2860                
Gly Ala Ser Asn Arg Thr Ile Ser Pro Lys Lys Ala Asp Ile Leu Asp
2865                2870                2875                2880
Val Val Gly Met Leu Tyr Val Gly Gly Leu Pro Ile Asn Tyr Thr Thr
                2885                2890                2895    
Arg Arg Ile Gly Pro Val Thr Tyr Ser Ile Asp Gly Cys Val Arg Asn
            2900                2905                2910        
Leu His Met Ala Glu Ala Pro Ala Asp Leu Glu Gln Pro Thr Ser Ser
        2915                2920                2925            
Phe His Val Gly Thr Cys Phe Ala Asn Ala Gln Arg Gly Thr Tyr Phe
    2930                2935                2940                
Asp Gly Thr Gly Phe Ala Lys Ala Val Gly Gly Phe Lys Val Gly Leu
2945                2950                2955                2960
Asp Leu Leu Val Glu Phe Glu Phe Arg Thr Thr Thr Thr Thr Gly Val
                2965                2970                2975    
Leu Leu Gly Ile Ser Ser Gln Lys Met Asp Gly Met Gly Ile Glu Met
            2980                2985                2990        
Ile Asp Glu Lys Leu Met Phe His Val Asp Asn Gly Ala Gly Arg Phe
        2995                3000                3005            
Thr Ala Val Tyr Asp Ala Gly Val Pro Gly His Leu Cys Asp Gly Gln
    3010                3015                3020                
Trp His Lys Val Thr Ala Asn Lys Ile Lys His Arg Ile Glu Leu Thr
3025                3030                3035                3040
Val Asp Gly Asn Gln Val Glu Ala Gln Ser Pro Asn Pro Ala Ser Thr
                3045                3050                3055    
Ser Ala Asp Thr Asn Asp Pro Val Phe Val Gly Gly Phe Pro Asp Asp
            3060                3065                3070        
Leu Lys Gln Phe Gly Leu Thr Thr Ser Ile Pro Phe Arg Gly Cys Ile
        3075                3080                3085            
Arg Ser Leu Lys Leu Thr Lys Gly Thr Gly Lys Pro Leu Glu Val Asn
    3090                3095                3100                
Phe Ala Lys Ala Leu Glu Leu Arg Gly Val Gln Pro Val Ser Cys Pro
3105                3110                3115                3120
Ala Asn
        


<210> 6551
<211> 628
<212> PRT
<213> Homo sapiens

<400> 6551
Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu
 1               5                  10                  15      
Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu
            20                  25                  30          
Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser
        35                  40                  45              
Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu
    50                  55                  60                  
Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser
65                  70                  75                  80  
Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg
                85                  90                  95      
Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu
            100                 105                 110         
Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg
        115                 120                 125             
Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe
    130                 135                 140                 
Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser
145                 150                 155                 160 
Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn
                165                 170                 175     
Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu
            180                 185                 190         
Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr
        195                 200                 205             
Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu
    210                 215                 220                 
Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His
225                 230                 235                 240 
Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe
                245                 250                 255     
His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly
            260                 265                 270         
Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln
        275                 280                 285             
Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe
    290                 295                 300                 
Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly
305                 310                 315                 320 
Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly
                325                 330                 335     
Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys
            340                 345                 350         
Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu
        355                 360                 365             
Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys
    370                 375                 380                 
Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser
385                 390                 395                 400 
Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe
                405                 410                 415     
Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro
            420                 425                 430         
Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro
        435                 440                 445             
Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg
    450                 455                 460                 
Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp
465                 470                 475                 480 
Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile
                485                 490                 495     
Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr
            500                 505                 510         
Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His
        515                 520                 525             
Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr
    530                 535                 540                 
Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu
545                 550                 555                 560 
Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly
                565                 570                 575     
Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu
            580                 585                 590         
Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu
        595                 600                 605             
Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe
    610                 615                 620                 
Gly Asp Glu Cys
625             


<210> 6552
<211> 628
<212> PRT
<213> Homo sapiens

<400> 6552
Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu
 1               5                  10                  15      
Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu
            20                  25                  30          
Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser
        35                  40                  45              
Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu
    50                  55                  60                  
Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser
65                  70                  75                  80  
Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg
                85                  90                  95      
Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu
            100                 105                 110         
Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg
        115                 120                 125             
Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe
    130                 135                 140                 
Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser
145                 150                 155                 160 
Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn
                165                 170                 175     
Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu
            180                 185                 190         
Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr
        195                 200                 205             
Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu
    210                 215                 220                 
Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His
225                 230                 235                 240 
Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe
                245                 250                 255     
His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly
            260                 265                 270         
Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln
        275                 280                 285             
Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe
    290                 295                 300                 
Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly
305                 310                 315                 320 
Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly
                325                 330                 335     
Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys
            340                 345                 350         
Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu
        355                 360                 365             
Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys
    370                 375                 380                 
Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser
385                 390                 395                 400 
Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe
                405                 410                 415     
Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro
            420                 425                 430         
Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro
        435                 440                 445             
Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg
    450                 455                 460                 
Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp
465                 470                 475                 480 
Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile
                485                 490                 495     
Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr
            500                 505                 510         
Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His
        515                 520                 525             
Gly Asn Lys Arg His Val Phe His Phe Gly Ala Val Ser Pro Gln Thr
    530                 535                 540                 
Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu
545                 550                 555                 560 
Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly
                565                 570                 575     
Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu
            580                 585                 590         
Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu
        595                 600                 605             
Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe
    610                 615                 620                 
Gly Asp Glu Cys
625             


<210> 6553
<211> 4391
<212> PRT
<213> Homo sapiens

<400> 6553
Met Gly Trp Arg Ala Pro Gly Ala Leu Leu Leu Ala Leu Leu Leu His
 1               5                  10                  15      
Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu
            20                  25                  30          
Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp
        35                  40                  45              
Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile
    50                  55                  60                  
Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln
65                  70                  75                  80  
Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr
                85                  90                  95      
Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser
            100                 105                 110         
Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly
        115                 120                 125             
Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val
    130                 135                 140                 
Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln
145                 150                 155                 160 
Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser
                165                 170                 175     
Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val
            180                 185                 190         
Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser
        195                 200                 205             
Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp
    210                 215                 220                 
Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly
225                 230                 235                 240 
Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro
                245                 250                 255     
Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro
            260                 265                 270         
Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln
        275                 280                 285             
Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys
    290                 295                 300                 
Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly
305                 310                 315                 320 
Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His
                325                 330                 335     
Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp
            340                 345                 350         
Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys
        355                 360                 365             
Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala
    370                 375                 380                 
Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu
385                 390                 395                 400 
Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile
                405                 410                 415     
Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly
            420                 425                 430         
Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro
        435                 440                 445             
Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu
    450                 455                 460                 
Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu
465                 470                 475                 480 
Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu
                485                 490                 495     
Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu
            500                 505                 510         
Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser
        515                 520                 525             
Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe
    530                 535                 540                 
Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln
545                 550                 555                 560 
Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser
                565                 570                 575     
Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His
            580                 585                 590         
Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp
        595                 600                 605             
Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg
    610                 615                 620                 
Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Val Gly Ala
625                 630                 635                 640 
Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala
                645                 650                 655     
Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu
            660                 665                 670         
Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser
        675                 680                 685             
Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser
    690                 695                 700                 
Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala Thr
705                 710                 715                 720 
Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly
                725                 730                 735     
Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val
            740                 745                 750         
Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Ser Cys Asn Gly
        755                 760                 765             
His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln
    770                 775                 780                 
His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe
785                 790                 795                 800 
Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys
                805                 810                 815     
Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp
            820                 825                 830         
Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly
        835                 840                 845             
Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln
    850                 855                 860                 
Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp
865                 870                 875                 880 
Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn
                885                 890                 895     
Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His
            900                 905                 910         
Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly
        915                 920                 925             
Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His
    930                 935                 940                 
Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser
945                 950                 955                 960 
Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu
                965                 970                 975     
Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser
            980                 985                 990         
Leu Pro Ser Arg Phe Leu Gly Asp Lys Val Thr Ser Tyr Gly Gly Glu
        995                 1000                1005            
Leu Arg Phe Thr Val Thr Gln Arg Ser Gln Pro Gly Ser Thr Pro Leu
    1010                1015                1020                
His Gly Gln Pro Leu Val Val Leu Gln Gly Asn Asn Ile Ile Leu Glu
1025                1030                1035                1040
His His Val Ala Gln Glu Pro Ser Pro Gly Gln Pro Ser Thr Phe Ile
                1045                1050                1055    
Val Pro Phe Arg Glu Gln Ala Trp Gln Arg Pro Asp Gly Gln Pro Ala
            1060                1065                1070        
Thr Arg Glu His Leu Leu Met Ala Leu Ala Gly Ile Asp Thr Leu Leu
        1075                1080                1085            
Ile Arg Ala Ser Tyr Ala Gln Gln Pro Ala Glu Ser Arg Val Ser Gly
    1090                1095                1100                
Ile Ser Met Asp Val Ala Val Pro Glu Glu Thr Gly Gln Asp Pro Ala
1105                1110                1115                1120
Leu Glu Val Glu Gln Cys Ser Cys Pro Pro Gly Tyr Arg Gly Pro Ser
                1125                1130                1135    
Cys Gln Asp Cys Asp Thr Gly Tyr Thr Arg Thr Pro Ser Gly Leu Tyr
            1140                1145                1150        
Leu Gly Thr Cys Glu Arg Cys Ser Cys His Gly His Ser Glu Ala Cys
        1155                1160                1165            
Glu Pro Glu Thr Gly Ala Cys Gln Gly Cys Gln His His Thr Glu Gly
    1170                1175                1180                
Pro Arg Cys Glu Gln Cys Gln Pro Gly Tyr Tyr Gly Asp Ala Gln Arg
1185                1190                1195                1200
Gly Thr Pro Gln Asp Cys Gln Leu Cys Pro Cys Tyr Gly Asp Pro Ala
                1205                1210                1215    
Ala Gly Gln Ala Ala His Thr Cys Phe Leu Asp Thr Asp Gly His Pro
            1220                1225                1230        
Thr Cys Asp Ala Cys Ser Pro Gly His Ser Gly Arg His Cys Glu Arg
        1235                1240                1245            
Cys Ala Pro Gly Tyr Tyr Gly Asn Pro Ser Gln Gly Gln Pro Cys Gln
    1250                1255                1260                
Arg Asp Ser Gln Val Pro Gly Pro Ile Gly Cys Asn Cys Asp Pro Gln
1265                1270                1275                1280
Gly Ser Val Ser Ser Gln Cys Asp Ala Ala Gly Gln Cys Gln Cys Lys
                1285                1290                1295    
Ala Gln Val Glu Gly Leu Thr Cys Ser His Cys Arg Pro His His Phe
            1300                1305                1310        
His Leu Ser Ala Ser Asn Pro Asp Gly Cys Leu Pro Cys Phe Cys Met
        1315                1320                1325            
Gly Ile Thr Gln Gln Cys Ala Ser Ser Ala Tyr Thr Arg His Leu Ile
    1330                1335                1340                
Ser Thr His Phe Ala Pro Gly Asp Phe Gln Gly Phe Ala Leu Val Asn
1345                1350                1355                1360
Pro Gln Arg Asn Ser Arg Leu Thr Gly Glu Phe Thr Val Glu Pro Val
                1365                1370                1375    
Pro Glu Gly Ala Gln Leu Ser Phe Gly Asn Phe Ala Gln Leu Gly His
            1380                1385                1390        
Glu Ser Phe Tyr Trp Gln Leu Pro Glu Thr Tyr Gln Gly Asp Lys Val
        1395                1400                1405            
Ala Ala Tyr Gly Gly Lys Leu Arg Tyr Thr Leu Ser Tyr Thr Ala Gly
    1410                1415                1420                
Pro Gln Gly Ser Pro Leu Ser Asp Pro Asp Val Gln Ile Thr Gly Asn
1425                1430                1435                1440
Asn Ile Met Leu Val Ala Ser Gln Pro Ala Leu Gln Gly Pro Glu Arg
                1445                1450                1455    
Arg Ser Tyr Glu Ile Met Phe Arg Glu Glu Phe Trp Arg Arg Pro Asp
            1460                1465                1470        
Gly Gln Pro Ala Thr Arg Glu His Leu Leu Met Ala Leu Ala Asp Leu
        1475                1480                1485            
Asp Glu Leu Leu Ile Arg Ala Thr Phe Ser Ser Val Pro Leu Val Ala
    1490                1495                1500                
Ser Ile Ser Ala Val Ser Leu Glu Val Ala Gln Pro Gly Pro Ser Asn
1505                1510                1515                1520
Arg Pro Arg Ala Leu Glu Val Glu Glu Cys Arg Cys Pro Pro Gly Tyr
                1525                1530                1535    
Ile Gly Leu Ser Cys Gln Asp Cys Ala Pro Gly Tyr Thr Arg Thr Gly
            1540                1545                1550        
Ser Gly Leu Tyr Leu Gly His Cys Glu Leu Cys Glu Cys Asn Gly His
        1555                1560                1565            
Ser Asp Leu Cys His Pro Glu Thr Gly Ala Cys Ser Gln Cys Gln His
    1570                1575                1580                
Asn Ala Ala Gly Glu Phe Cys Glu Leu Cys Ala Pro Gly Tyr Tyr Gly
1585                1590                1595                1600
Asp Ala Thr Ala Gly Thr Pro Glu Asp Cys Gln Pro Cys Ala Cys Pro
                1605                1610                1615    
Leu Thr Asn Pro Glu Asn Met Phe Ser Arg Thr Cys Glu Ser Leu Gly
            1620                1625                1630        
Ala Gly Gly Tyr Arg Cys Thr Ala Cys Glu Pro Gly Tyr Thr Gly Gln
        1635                1640                1645            
Tyr Cys Glu Gln Cys Gly Pro Gly Tyr Val Gly Asn Pro Ser Val Gln
    1650                1655                1660                
Gly Gly Gln Cys Leu Pro Glu Thr Asn Gln Ala Pro Leu Val Val Glu
1665                1670                1675                1680
Val His Pro Ala Arg Ser Ile Val Pro Gln Gly Gly Ser His Ser Leu
                1685                1690                1695    
Arg Cys Gln Val Ser Gly Ser Pro Pro His Tyr Phe Tyr Trp Ser Arg
            1700                1705                1710        
Glu Asp Gly Arg Pro Val Pro Ser Gly Thr Gln Gln Arg His Gln Gly
        1715                1720                1725            
Ser Glu Leu His Phe Pro Ser Val Gln Pro Ser Asp Ala Gly Val Tyr
    1730                1735                1740                
Ile Cys Thr Cys Arg Asn Leu His Gln Ser Asn Thr Ser Arg Ala Glu
1745                1750                1755                1760
Leu Leu Val Thr Glu Ala Pro Ser Lys Pro Ile Thr Val Thr Val Glu
                1765                1770                1775    
Glu Gln Arg Ser Gln Ser Val Arg Pro Gly Ala Asp Val Thr Phe Ile
            1780                1785                1790        
Cys Thr Ala Lys Ser Lys Ser Pro Ala Tyr Thr Leu Val Trp Thr Arg
        1795                1800                1805            
Leu His Asn Gly Lys Leu Pro Thr Arg Ala Met Asp Phe Asn Gly Ile
    1810                1815                1820                
Leu Thr Ile Arg Asn Val Gln Leu Ser Asp Ala Gly Thr Tyr Val Cys
1825                1830                1835                1840
Thr Gly Ser Asn Met Phe Ala Met Asp Gln Gly Thr Ala Thr Leu His
                1845                1850                1855    
Val Gln Ala Ser Gly Thr Leu Ser Ala Pro Val Val Ser Ile His Pro
            1860                1865                1870        
Pro Gln Leu Thr Val Gln Pro Gly Gln Leu Ala Glu Phe Arg Cys Ser
        1875                1880                1885            
Ala Thr Gly Ser Pro Thr Pro Thr Leu Glu Trp Thr Gly Gly Pro Gly
    1890                1895                1900                
Gly Gln Leu Pro Ala Lys Ala Gln Ile His Gly Gly Ile Leu Arg Leu
1905                1910                1915                1920
Pro Ala Val Glu Pro Thr Asp Gln Ala Gln Tyr Leu Cys Arg Ala His
                1925                1930                1935    
Ser Ser Ala Gly Gln Gln Val Ala Arg Ala Val Leu His Val His Gly
            1940                1945                1950        
Gly Gly Gly Pro Arg Val Gln Val Ser Pro Glu Arg Thr Gln Val His
        1955                1960                1965            
Ala Gly Arg Thr Val Arg Leu Tyr Cys Arg Ala Ala Gly Val Pro Ser
    1970                1975                1980                
Ala Thr Ile Thr Trp Arg Lys Glu Gly Gly Ser Leu Pro Pro Gln Ala
1985                1990                1995                2000
Arg Ser Glu Arg Thr Asp Ile Ala Thr Leu Leu Ile Pro Ala Ile Thr
                2005                2010                2015    
Thr Ala Asp Ala Gly Phe Tyr Leu Cys Val Ala Thr Ser Pro Ala Gly
            2020                2025                2030        
Thr Ala Gln Ala Arg Ile Gln Val Val Val Leu Ser Ala Ser Asp Ala
        2035                2040                2045            
Ser Pro Pro Pro Val Lys Ile Glu Ser Ser Ser Pro Ser Val Thr Glu
    2050                2055                2060                
Gly Gln Thr Leu Asp Leu Asn Cys Val Val Ala Gly Ser Ala His Ala
2065                2070                2075                2080
Gln Val Thr Trp Tyr Arg Arg Gly Gly Ser Leu Pro Pro His Thr Gln
                2085                2090                2095    
Val His Gly Ser Arg Leu Arg Leu Pro Gln Val Ser Pro Ala Asp Ser
            2100                2105                2110        
Gly Glu Tyr Val Cys Arg Val Glu Asn Gly Ser Gly Pro Lys Glu Ala
        2115                2120                2125            
Ser Ile Thr Val Ser Val Leu His Gly Thr His Ser Gly Pro Ser Tyr
    2130                2135                2140                
Thr Pro Val Pro Gly Ser Thr Arg Pro Ile Arg Ile Glu Pro Ser Ser
2145                2150                2155                2160
Ser His Val Ala Glu Gly Gln Thr Leu Asp Leu Asn Cys Val Val Pro
                2165                2170                2175    
Gly Gln Ala His Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu
            2180                2185                2190        
Pro Ala Arg His Gln Thr His Gly Ser Leu Leu Arg Leu His Gln Val
        2195                2200                2205            
Thr Pro Ala Asp Ser Gly Glu Tyr Val Cys His Val Val Gly Thr Ser
    2210                2215                2220                
Gly Pro Leu Glu Ala Ser Val Leu Val Thr Ile Glu Ala Ser Val Ile
2225                2230                2235                2240
Pro Gly Pro Ile Pro Pro Val Arg Ile Glu Ser Ser Ser Ser Thr Val
                2245                2250                2255    
Ala Glu Gly Gln Thr Leu Asp Leu Ser Cys Val Val Ala Gly Gln Ala
            2260                2265                2270        
His Ala Gln Val Thr Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ala Arg
        2275                2280                2285            
His Gln Val Arg Gly Ser Arg Leu Tyr Ile Phe Gln Ala Ser Pro Ala
    2290                2295                2300                
Asp Ala Gly Gln Tyr Val Cys Arg Ala Ser Asn Gly Met Glu Ala Ser
2305                2310                2315                2320
Ile Thr Val Thr Val Thr Gly Thr Gln Gly Ala Asn Leu Ala Tyr Pro
                2325                2330                2335    
Ala Gly Ser Thr Gln Pro Ile Arg Ile Glu Pro Ser Ser Ser Gln Val
            2340                2345                2350        
Ala Glu Gly Gln Thr Leu Asp Leu Asn Cys Val Val Pro Gly Gln Ser
        2355                2360                2365            
His Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro Val Arg
    2370                2375                2380                
His Gln Thr His Gly Ser Leu Leu Arg Leu Tyr Gln Ala Ser Pro Ala
2385                2390                2395                2400
Asp Ser Gly Glu Tyr Val Cys Arg Val Leu Gly Ser Ser Val Pro Leu
                2405                2410                2415    
Glu Ala Ser Val Leu Val Thr Ile Glu Pro Ala Gly Ser Val Pro Ala
            2420                2425                2430        
Leu Gly Val Thr Pro Thr Val Arg Ile Glu Ser Ser Ser Ser Gln Val
        2435                2440                2445            
Ala Glu Gly Gln Thr Leu Asp Leu Asn Cys Leu Val Ala Gly Gln Ala
    2450                2455                2460                
His Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro Ala Arg
2465                2470                2475                2480
His Gln Val His Gly Ser Arg Leu Arg Leu Leu Gln Val Thr Pro Ala
                2485                2490                2495    
Asp Ser Gly Glu Tyr Val Cys Arg Val Val Gly Ser Ser Gly Thr Gln
            2500                2505                2510        
Glu Ala Ser Val Leu Val Thr Ile Gln Gln Arg Leu Ser Gly Ser His
        2515                2520                2525            
Ser Gln Gly Val Ala Tyr Pro Val Arg Ile Glu Ser Ser Ser Ala Ser
    2530                2535                2540                
Leu Ala Asn Gly His Thr Leu Asp Leu Asn Cys Leu Val Ala Ser Gln
2545                2550                2555                2560
Ala Pro His Thr Ile Thr Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ser
                2565                2570                2575    
Arg His Gln Ile Val Gly Ser Arg Leu Arg Ile Pro Gln Val Thr Pro
            2580                2585                2590        
Ala Asp Ser Gly Glu Tyr Val Cys His Val Ser Asn Gly Ala Gly Ser
        2595                2600                2605            
Arg Glu Thr Ser Leu Ile Val Thr Ile Gln Gly Ser Gly Ser Ser His
    2610                2615                2620                
Val Pro Ser Val Ser Pro Pro Ile Arg Ile Glu Ser Ser Ser Pro Thr
2625                2630                2635                2640
Val Val Glu Gly Gln Thr Leu Asp Leu Asn Cys Val Val Ala Arg Gln
                2645                2650                2655    
Pro Gln Ala Ile Ile Thr Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ser
            2660                2665                2670        
Arg His Gln Thr His Gly Ser His Leu Arg Leu His Gln Met Ser Val
        2675                2680                2685            
Ala Asp Ser Gly Glu Tyr Val Cys Arg Ala Asn Asn Asn Ile Asp Ala
    2690                2695                2700                
Leu Glu Ala Ser Ile Val Ile Ser Val Ser Pro Ser Ala Gly Ser Pro
2705                2710                2715                2720
Ser Ala Pro Gly Ser Ser Met Pro Ile Arg Ile Glu Ser Ser Ser Ser
                2725                2730                2735    
His Val Ala Glu Gly Glu Thr Leu Asp Leu Asn Cys Val Val Pro Gly
            2740                2745                2750        
Gln Ala His Ala Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro
        2755                2760                2765            
Ser His His Gln Thr Arg Gly Ser Arg Leu Arg Leu His His Val Ser
    2770                2775                2780                
Pro Ala Asp Ser Gly Glu Tyr Val Cys Arg Val Met Gly Ser Ser Gly
2785                2790                2795                2800
Pro Leu Glu Ala Ser Val Leu Val Thr Ile Glu Ala Ser Gly Ser Ser
                2805                2810                2815    
Ala Val His Val Pro Ala Pro Gly Gly Ala Pro Pro Ile Arg Ile Glu
            2820                2825                2830        
Pro Ser Ser Ser Arg Val Ala Glu Gly Gln Thr Leu Asp Leu Lys Cys
        2835                2840                2845            
Val Val Pro Gly Gln Ala His Ala Gln Val Thr Trp His Lys Arg Gly
    2850                2855                2860                
Gly Asn Leu Pro Ala Arg His Gln Val His Gly Pro Leu Leu Arg Leu
2865                2870                2875                2880
Asn Gln Val Ser Pro Ala Asp Ser Gly Glu Tyr Ser Cys Gln Val Thr
                2885                2890                2895    
Gly Ser Ser Gly Thr Leu Glu Ala Ser Val Leu Val Thr Ile Glu Pro
            2900                2905                2910        
Ser Ser Pro Gly Pro Ile Pro Ala Pro Gly Leu Ala Gln Pro Ile Tyr
        2915                2920                2925            
Ile Glu Ala Ser Ser Ser His Val Thr Glu Gly Gln Thr Leu Asp Leu
    2930                2935                2940                
Asn Cys Val Val Pro Gly Gln Ala His Ala Gln Val Thr Trp Tyr Lys
2945                2950                2955                2960
Arg Gly Gly Ser Leu Pro Ala Arg His Gln Thr His Gly Ser Gln Leu
                2965                2970                2975    
Arg Leu His Leu Val Ser Pro Ala Asp Ser Gly Glu Tyr Val Cys Arg
            2980                2985                2990        
Ala Ala Ser Gly Pro Gly Pro Glu Gln Glu Ala Ser Phe Thr Val Thr
        2995                3000                3005            
Val Pro Pro Ser Glu Gly Ser Ser Tyr Arg Leu Arg Ser Pro Val Ile
    3010                3015                3020                
Ser Ile Asp Pro Pro Ser Ser Thr Val Gln Gln Gly Gln Asp Ala Ser
3025                3030                3035                3040
Phe Lys Cys Leu Ile His Asp Gly Ala Ala Pro Ile Ser Leu Glu Trp
                3045                3050                3055    
Lys Thr Arg Asn Gln Glu Leu Glu Asp Asn Val His Ile Ser Pro Asn
            3060                3065                3070        
Gly Ser Ile Ile Thr Ile Val Gly Thr Arg Pro Ser Asn His Gly Thr
        3075                3080                3085            
Tyr Arg Cys Val Ala Ser Asn Ala Tyr Gly Val Ala Gln Ser Val Val
    3090                3095                3100                
Asn Leu Ser Val His Gly Pro Pro Thr Val Ser Val Leu Pro Glu Gly
3105                3110                3115                3120
Pro Val Trp Val Lys Val Gly Lys Ala Val Thr Leu Glu Cys Val Ser
                3125                3130                3135    
Ala Gly Glu Pro Arg Ser Ser Ala Arg Trp Thr Arg Ile Ser Ser Thr
            3140                3145                3150        
Pro Ala Lys Leu Glu Gln Arg Thr Tyr Gly Leu Met Asp Ser His Ala
        3155                3160                3165            
Val Leu Gln Ile Ser Ser Ala Lys Pro Ser Asp Ala Gly Thr Tyr Val
    3170                3175                3180                
Cys Leu Ala Gln Asn Ala Leu Gly Thr Ala Gln Lys Gln Val Glu Val
3185                3190                3195                3200
Ile Val Asp Thr Gly Ala Met Ala Pro Gly Ala Pro Gln Val Gln Ala
                3205                3210                3215    
Glu Glu Ala Glu Leu Thr Val Glu Ala Gly His Thr Ala Thr Leu Arg
            3220                3225                3230        
Cys Ser Ala Thr Gly Ser Pro Ala Pro Thr Ile His Trp Ser Lys Leu
        3235                3240                3245            
Arg Ser Pro Leu Pro Trp Gln His Arg Leu Glu Gly Asp Thr Leu Ile
    3250                3255                3260                
Ile Pro Arg Val Ala Gln Gln Asp Ser Gly Gln Tyr Ile Cys Asn Ala
3265                3270                3275                3280
Thr Ser Pro Ala Gly His Ala Glu Ala Thr Ile Ile Leu His Val Glu
                3285                3290                3295    
Ser Pro Pro Tyr Ala Thr Thr Val Pro Glu His Ala Ser Val Gln Ala
            3300                3305                3310        
Gly Glu Thr Val Gln Leu Gln Cys Leu Ala His Gly Thr Pro Pro Leu
        3315                3320                3325            
Thr Phe Gln Trp Ser Arg Val Gly Ser Ser Leu Pro Gly Arg Ala Thr
    3330                3335                3340                
Ala Arg Asn Glu Leu Leu His Phe Glu Arg Ala Ala Pro Glu Asp Ser
3345                3350                3355                3360
Gly Arg Tyr Arg Cys Arg Val Thr Asn Lys Val Gly Ser Ala Glu Ala
                3365                3370                3375    
Phe Ala Gln Leu Leu Val Gln Gly Pro Pro Gly Ser Leu Pro Ala Thr
            3380                3385                3390        
Ser Ile Pro Ala Gly Ser Thr Pro Thr Val Gln Val Thr Pro Gln Leu
        3395                3400                3405            
Glu Thr Lys Ser Ile Gly Ala Ser Val Glu Phe His Cys Ala Val Pro
    3410                3415                3420                
Ser Asp Arg Gly Thr Gln Leu Arg Trp Phe Lys Glu Gly Gly Gln Leu
3425                3430                3435                3440
Pro Pro Gly His Ser Val Gln Asp Gly Val Leu Arg Ile Gln Asn Leu
                3445                3450                3455    
Asp Gln Ser Cys Gln Gly Thr Tyr Ile Cys Gln Ala His Gly Pro Trp
            3460                3465                3470        
Gly Lys Ala Gln Ala Ser Ala Gln Leu Val Ile Gln Ala Leu Pro Ser
        3475                3480                3485            
Val Leu Ile Asn Ile Arg Thr Ser Val Gln Thr Val Val Val Gly His
    3490                3495                3500                
Ala Val Glu Phe Glu Cys Leu Ala Leu Gly Asp Pro Lys Pro Gln Val
3505                3510                3515                3520
Thr Trp Ser Lys Val Gly Gly His Leu Arg Pro Gly Ile Val Gln Ser
                3525                3530                3535    
Gly Gly Val Val Arg Ile Ala His Val Glu Leu Ala Asp Ala Gly Gln
            3540                3545                3550        
Tyr Arg Cys Thr Ala Thr Asn Ala Ala Gly Thr Thr Gln Ser His Val
        3555                3560                3565            
Leu Leu Leu Val Gln Ala Leu Pro Gln Ile Ser Met Pro Gln Glu Val
    3570                3575                3580                
Arg Val Pro Ala Gly Ser Ala Ala Val Phe Pro Cys Ile Ala Ser Gly
3585                3590                3595                3600
Tyr Pro Thr Pro Asp Ile Ser Trp Ser Lys Leu Asp Gly Ser Leu Pro
                3605                3610                3615    
Pro Asp Ser Arg Leu Glu Asn Asn Met Leu Met Leu Pro Ser Val Arg
            3620                3625                3630        
Pro Gln Asp Ala Gly Thr Tyr Val Cys Thr Ala Thr Asn Arg Gln Gly
        3635                3640                3645            
Lys Val Lys Ala Phe Ala His Leu Gln Val Pro Glu Arg Val Val Pro
    3650                3655                3660                
Tyr Phe Thr Gln Thr Pro Tyr Ser Phe Leu Pro Leu Pro Thr Ile Lys
3665                3670                3675                3680
Asp Ala Tyr Arg Lys Phe Glu Ile Lys Ile Thr Phe Arg Pro Asp Ser
                3685                3690                3695    
Ala Asp Gly Met Leu Leu Tyr Asn Gly Gln Lys Arg Val Pro Gly Ser
            3700                3705                3710        
Pro Thr Asn Leu Ala Asn Arg Gln Pro Asp Phe Ile Ser Phe Gly Leu
        3715                3720                3725            
Val Gly Gly Arg Pro Glu Phe Arg Phe Asp Ala Gly Ser Gly Met Ala
    3730                3735                3740                
Thr Ile Arg His Pro Thr Pro Leu Ala Leu Gly His Phe His Thr Val
3745                3750                3755                3760
Thr Leu Leu Arg Ser Leu Thr Gln Gly Ser Leu Ile Val Gly Asp Leu
                3765                3770                3775    
Ala Pro Val Asn Gly Thr Ser Gln Gly Lys Phe Gln Gly Leu Asp Leu
            3780                3785                3790        
Asn Glu Glu Leu Tyr Leu Gly Gly Tyr Pro Asp Tyr Gly Ala Ile Pro
        3795                3800                3805            
Lys Ala Gly Leu Ser Ser Gly Phe Ile Gly Cys Val Arg Glu Leu Arg
    3810                3815                3820                
Ile Gln Gly Glu Glu Ile Val Phe His Asp Leu Asn Leu Thr Ala His
3825                3830                3835                3840
Gly Ile Ser His Cys Pro Thr Cys Arg Asp Arg Pro Cys Gln Asn Gly
                3845                3850                3855    
Gly Gln Cys His Asp Ser Glu Ser Ser Ser Tyr Val Cys Val Cys Pro
            3860                3865                3870        
Ala Gly Phe Thr Gly Ser Arg Cys Glu His Ser Gln Ala Leu His Cys
        3875                3880                3885            
His Pro Glu Ala Cys Gly Pro Asp Ala Thr Cys Val Asn Arg Pro Asp
    3890                3895                3900                
Gly Arg Gly Tyr Thr Cys Arg Cys His Leu Gly Arg Ser Gly Leu Arg
3905                3910                3915                3920
Cys Glu Glu Gly Val Thr Val Thr Thr Pro Ser Leu Ser Gly Ala Gly
                3925                3930                3935    
Ser Tyr Leu Ala Leu Pro Ala Leu Thr Asn Thr His His Glu Leu Arg
            3940                3945                3950        
Leu Asp Val Glu Phe Lys Pro Leu Ala Pro Asp Gly Val Leu Leu Phe
        3955                3960                3965            
Ser Gly Gly Lys Ser Gly Pro Val Glu Asp Phe Val Ser Leu Ala Met
    3970                3975                3980                
Val Gly Gly His Leu Glu Phe Arg Tyr Glu Leu Gly Ser Gly Leu Ala
3985                3990                3995                4000
Val Leu Arg Ser Ala Glu Pro Leu Ala Leu Gly Arg Trp His Arg Val
                4005                4010                4015    
Ser Ala Glu Arg Leu Asn Lys Asp Gly Ser Leu Arg Val Asn Gly Gly
            4020                4025                4030        
Arg Pro Val Leu Arg Ser Ser Pro Gly Lys Ser Gln Gly Leu Asn Leu
        4035                4040                4045            
His Thr Leu Leu Tyr Leu Gly Gly Val Glu Pro Ser Val Pro Leu Ser
    4050                4055                4060                
Pro Ala Thr Asn Met Ser Ala His Phe Arg Gly Cys Val Gly Glu Val
4065                4070                4075                4080
Ser Val Asn Gly Lys Arg Leu Asp Leu Thr Tyr Ser Phe Leu Gly Ser
                4085                4090                4095    
Gln Gly Ile Gly Gln Cys Tyr Asp Ser Ser Pro Cys Glu Arg Gln Pro
            4100                4105                4110        
Cys Gln His Gly Ala Thr Cys Met Pro Ala Gly Glu Tyr Glu Phe Gln
        4115                4120                4125            
Cys Leu Cys Arg Asp Gly Phe Lys Gly Asp Leu Cys Glu His Glu Glu
    4130                4135                4140                
Asn Pro Cys Gln Leu Arg Glu Pro Cys Leu His Gly Gly Thr Cys Gln
4145                4150                4155                4160
Gly Thr Arg Cys Leu Cys Leu Pro Gly Phe Ser Gly Pro Arg Cys Gln
                4165                4170                4175    
Gln Gly Ser Gly His Gly Ile Ala Glu Ser Asp Trp His Leu Glu Gly
            4180                4185                4190        
Ser Gly Gly Asn Asp Ala Pro Gly Gln Tyr Gly Ala Tyr Phe His Asp
        4195                4200                4205            
Asp Gly Phe Leu Ala Phe Pro Gly His Val Phe Ser Arg Ser Leu Pro
    4210                4215                4220                
Glu Val Pro Glu Thr Ile Glu Leu Glu Val Arg Thr Ser Thr Ala Ser
4225                4230                4235                4240
Gly Leu Leu Leu Trp Gln Gly Val Glu Val Gly Glu Ala Gly Gln Gly
                4245                4250                4255    
Lys Asp Phe Ile Ser Leu Gly Leu Gln Asp Gly His Leu Val Phe Arg
            4260                4265                4270        
Tyr Gln Leu Gly Ser Gly Glu Ala Arg Leu Val Ser Glu Asp Pro Ile
        4275                4280                4285            
Asn Asp Gly Glu Trp His Arg Val Thr Ala Leu Arg Glu Gly Arg Arg
    4290                4295                4300                
Gly Ser Ile Gln Val Asp Gly Glu Glu Leu Val Ser Gly Arg Ser Pro
4305                4310                4315                4320
Gly Pro Asn Val Ala Val Asn Ala Lys Gly Ser Val Tyr Ile Gly Gly
                4325                4330                4335    
Ala Pro Asp Val Ala Thr Leu Thr Gly Gly Arg Phe Ser Ser Gly Ile
            4340                4345                4350        
Thr Gly Cys Val Lys Asn Leu Val Leu His Ser Ala Arg Pro Gly Ala
        4355                4360                4365            
Pro Pro Pro Gln Pro Leu Asp Leu Gln His Arg Ala Gln Ala Gly Ala
    4370                4375                4380                
Asn Thr Arg Pro Cys Pro Ser
4385                4390    


<210> 6554
<211> 316
<212> PRT
<213> Homo sapiens

<400> 6554
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala
 1               5                  10                  15      
Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln
            20                  25                  30          
Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu
        35                  40                  45              
Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn
    50                  55                  60                  
Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala
65                  70                  75                  80  
Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe
                85                  90                  95      
Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val
            100                 105                 110         
Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp
        115                 120                 125             
Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys
    130                 135                 140                 
Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr
145                 150                 155                 160 
Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val
                165                 170                 175     
Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr
            180                 185                 190         
Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu
        195                 200                 205             
Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn
    210                 215                 220                 
Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln
225                 230                 235                 240 
Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser
                245                 250                 255     
Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg
            260                 265                 270         
Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln
        275                 280                 285             
Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His
    290                 295                 300                 
Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala
305                 310                 315     


<210> 6555
<211> 388
<212> PRT
<213> Homo sapiens

<400> 6555
Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr
 1               5                  10                  15      
Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val Phe Trp
            20                  25                  30          
Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln
        35                  40                  45              
Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu Arg Val
    50                  55                  60                  
Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val
65                  70                  75                  80  
Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln Arg Ser
                85                  90                  95      
Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val Val Ala
            100                 105                 110         
Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro Glu Pro
        115                 120                 125             
Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr
    130                 135                 140                 
Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly Ser Ala
145                 150                 155                 160 
Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn
                165                 170                 175     
Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe
            180                 185                 190         
Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu
        195                 200                 205             
Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn
    210                 215                 220                 
Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr
225                 230                 235                 240 
Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val
                245                 250                 255     
Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly
            260                 265                 270         
Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala Asn Gly
        275                 280                 285             
Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His
    290                 295                 300                 
Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro Glu Ala
305                 310                 315                 320 
Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu Val
                325                 330                 335     
Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu Glu
            340                 345                 350         
Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser Lys
        355                 360                 365             
Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp Asp Gly
    370                 375                 380                 
Gln Glu Ile Ala
385             


<210> 6556
<211> 750
<212> PRT
<213> Homo sapiens

<400> 6556
Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg
 1               5                  10                  15      
Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe
            20                  25                  30          
Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu
        35                  40                  45              
Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu
    50                  55                  60                  
Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile
65                  70                  75                  80  
Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile
                85                  90                  95      
Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His
            100                 105                 110         
Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile
        115                 120                 125             
Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe
    130                 135                 140                 
Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro
145                 150                 155                 160 
Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr
                165                 170                 175     
Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met
            180                 185                 190         
Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val
        195                 200                 205             
Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly
    210                 215                 220                 
Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys
225                 230                 235                 240 
Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly
                245                 250                 255     
Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr
            260                 265                 270         
Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly
        275                 280                 285             
Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys
    290                 295                 300                 
Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg
305                 310                 315                 320 
Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn
                325                 330                 335     
Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val
            340                 345                 350         
Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro
        355                 360                 365             
Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly
    370                 375                 380                 
Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg
385                 390                 395                 400 
Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile
                405                 410                 415     
Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr
            420                 425                 430         
Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala
        435                 440                 445             
Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val
    450                 455                 460                 
Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu
465                 470                 475                 480 
Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser
                485                 490                 495     
Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile
            500                 505                 510         
Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu
        515                 520                 525             
Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn
    530                 535                 540                 
Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu
545                 550                 555                 560 
Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val
                565                 570                 575     
Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val
            580                 585                 590         
Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala
        595                 600                 605             
Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr
    610                 615                 620                 
Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr
625                 630                 635                 640 
Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser
                645                 650                 655     
Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu
            660                 665                 670         
Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg
        675                 680                 685             
His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser
    690                 695                 700                 
Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp
705                 710                 715                 720 
Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala
                725                 730                 735     
Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala
            740                 745                 750 


<210> 6557
<211> 693
<212> PRT
<213> Homo sapiens

<400> 6557
Met Lys Ala Phe Leu Asp Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe
 1               5                  10                  15      
Leu Tyr Asn Phe Thr Gln Ile Pro His Leu Ala Gly Thr Glu Gln Asn
            20                  25                  30          
Phe Gln Leu Ala Lys Gln Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu
        35                  40                  45              
Asp Ser Val Glu Leu Ala His Tyr Asp Val Leu Leu Ser Tyr Pro Asn
    50                  55                  60                  
Lys Thr His Pro Asn Tyr Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu
65                  70                  75                  80  
Ile Phe Asn Thr Ser Leu Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn
                85                  90                  95      
Val Ser Asp Ile Val Pro Pro Phe Ser Ala Phe Ser Pro Gln Gly Met
            100                 105                 110         
Pro Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe
        115                 120                 125             
Phe Lys Leu Glu Arg Asp Met Lys Ile Asn Cys Ser Gly Lys Ile Val
    130                 135                 140                 
Ile Ala Arg Tyr Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala
145                 150                 155                 160 
Gln Leu Ala Gly Ala Lys Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp
                165                 170                 175     
Tyr Phe Ala Pro Gly Val Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro
            180                 185                 190         
Gly Gly Gly Val Gln Arg Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly
        195                 200                 205             
Asp Pro Leu Thr Pro Gly Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg
    210                 215                 220                 
Gly Ile Ala Glu Ala Val Gly Leu Pro Ser Ile Pro Val His Pro Ile
225                 230                 235                 240 
Gly Tyr Tyr Asp Ala Gln Lys Leu Leu Glu Lys Met Gly Gly Ser Ala
                245                 250                 255     
Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys Val Pro Tyr Asn Val
            260                 265                 270         
Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln Lys Val Lys Met His
        275                 280                 285             
Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr Asn Val Ile Gly Thr
    290                 295                 300                 
Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His
305                 310                 315                 320 
Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala
                325                 330                 335     
Val Val His Glu Ile Val Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly
            340                 345                 350         
Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu
        355                 360                 365             
Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu
    370                 375                 380                 
Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu
385                 390                 395                 400 
Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu
                405                 410                 415     
Val His Asn Leu Thr Lys Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu
            420                 425                 430         
Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu
        435                 440                 445             
Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe
    450                 455                 460                 
Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr
465                 470                 475                 480 
Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His
                485                 490                 495     
Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys Phe Tyr Asp Pro Met
            500                 505                 510         
Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg Gly Gly Met Val Phe
        515                 520                 525             
Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala
    530                 535                 540                 
Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys
545                 550                 555                 560 
His Pro Gln Glu Met Lys Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe
                565                 570                 575     
Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg
            580                 585                 590         
Leu Gln Asp Phe Asp Lys Ser Asn Pro Ile Val Leu Arg Met Met Asn
        595                 600                 605             
Asp Gln Leu Met Phe Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu
    610                 615                 620                 
Pro Asp Arg Pro Phe Tyr Arg His Val Ile Tyr Ala Pro Ser Ser His
625                 630                 635                 640 
Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe
                645                 650                 655     
Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala Trp Gly Glu Val Lys
            660                 665                 670         
Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr
        675                 680                 685             
Leu Ser Glu Val Ala
    690             


<210> 6558
<211> 243
<212> PRT
<213> Homo sapiens

<400> 6558
Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg
 1               5                  10                  15      
Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe
            20                  25                  30          
Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu
        35                  40                  45              
Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu
    50                  55                  60                  
Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile
65                  70                  75                  80  
Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile
                85                  90                  95      
Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His
            100                 105                 110         
Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile
        115                 120                 125             
Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe
    130                 135                 140                 
Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro
145                 150                 155                 160 
Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr
                165                 170                 175     
Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met
            180                 185                 190         
Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val
        195                 200                 205             
Phe Arg Gly Asn Lys Asn Met Leu Ile Gly Val Glu Leu Gln Arg Leu
    210                 215                 220                 
Leu Val Phe Gln Val Phe Leu Phe Ile Gln Leu Asp Thr Met Met His
225                 230                 235                 240 
Arg Ser Ser
            


<210> 6559
<211> 718
<212> PRT
<213> Homo sapiens

<400> 6559
Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg
 1               5                  10                  15      
Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe
            20                  25                  30          
Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu
        35                  40                  45              
Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu
    50                  55                  60                  
Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile
65                  70                  75                  80  
Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile
                85                  90                  95      
Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His
            100                 105                 110         
Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile
        115                 120                 125             
Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe
    130                 135                 140                 
Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro
145                 150                 155                 160 
Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr
                165                 170                 175     
Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met
            180                 185                 190         
Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val
        195                 200                 205             
Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly
    210                 215                 220                 
Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys
225                 230                 235                 240 
Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly
                245                 250                 255     
Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr
            260                 265                 270         
Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly
        275                 280                 285             
Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys
    290                 295                 300                 
Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg
305                 310                 315                 320 
Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn
                325                 330                 335     
Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val
            340                 345                 350         
Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro
        355                 360                 365             
Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly
    370                 375                 380                 
Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg
385                 390                 395                 400 
Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile
                405                 410                 415     
Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr
            420                 425                 430         
Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala
        435                 440                 445             
Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val
    450                 455                 460                 
Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu
465                 470                 475                 480 
Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser
                485                 490                 495     
Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile
            500                 505                 510         
Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu
        515                 520                 525             
Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn
    530                 535                 540                 
Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu
545                 550                 555                 560 
Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val
                565                 570                 575     
Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val
            580                 585                 590         
Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala
        595                 600                 605             
Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr
    610                 615                 620                 
Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr
625                 630                 635                 640 
Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser
                645                 650                 655     
His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser
            660                 665                 670         
Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp
        675                 680                 685             
Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala
    690                 695                 700                 
Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala
705                 710                 715             


<210> 6560
<211> 695
<212> PRT
<213> Homo sapiens

<400> 6560
Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg
 1               5                  10                  15      
Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe
            20                  25                  30          
Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu
        35                  40                  45              
Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu
    50                  55                  60                  
Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile
65                  70                  75                  80  
Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile
                85                  90                  95      
Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His
            100                 105                 110         
Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile
        115                 120                 125             
Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe
    130                 135                 140                 
Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro
145                 150                 155                 160 
Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr
                165                 170                 175     
Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met
            180                 185                 190         
Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val
        195                 200                 205             
Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly
    210                 215                 220                 
Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys
225                 230                 235                 240 
Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly
                245                 250                 255     
Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr
            260                 265                 270         
Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly
        275                 280                 285             
Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys
    290                 295                 300                 
Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg
305                 310                 315                 320 
Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn
                325                 330                 335     
Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val
            340                 345                 350         
Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro
        355                 360                 365             
Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly
    370                 375                 380                 
Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg
385                 390                 395                 400 
Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile
                405                 410                 415     
Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr
            420                 425                 430         
Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala
        435                 440                 445             
Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val
    450                 455                 460                 
Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu
465                 470                 475                 480 
Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser
                485                 490                 495     
Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile
            500                 505                 510         
Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu
        515                 520                 525             
Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn
    530                 535                 540                 
Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu
545                 550                 555                 560 
Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val
                565                 570                 575     
Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val
            580                 585                 590         
Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala
        595                 600                 605             
Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr
    610                 615                 620                 
Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr
625                 630                 635                 640 
Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser
                645                 650                 655     
Met Ser Ser Met Leu Gln Ala Ala Thr Thr Ser Met Gln Gly Ser His
            660                 665                 670         
Ser Gln Glu Phe Met Met Leu Cys Leu Ile Leu Lys Ala Lys Trp Thr
        675                 680                 685             
Leu Pro Arg Pro Gly Glu Lys
    690                 695 


<210> 6561
<211> 233
<212> PRT
<213> Homo sapiens

<400> 6561
Met Arg Pro Gln Gln Leu His Ala Thr Glu Ile Thr Ser Ser Gly Phe
 1               5                  10                  15      
Arg Leu Ala Trp Pro Pro Leu Leu Thr Ala Asp Ser Gly Tyr Tyr Val
            20                  25                  30          
Leu Glu Leu Val Pro Ser Ala Gln Pro Gly Ala Ala Arg Arg Gln Gln
        35                  40                  45              
Leu Pro Gly Asn Ala Thr Asp Trp Ile Trp Ala Gly Leu Asp Pro Asp
    50                  55                  60                  
Thr Asp Tyr Asp Val Ala Leu Val Pro Glu Ser Asn Val Arg Leu Leu
65                  70                  75                  80  
Arg Pro Gln Ile Leu Arg Val Arg Thr Arg Pro Gly Glu Ala Gly Pro
                85                  90                  95      
Gly Ala Ser Gly Pro Glu Ser Gly Ala Gly Pro Ala Pro Thr Gln Leu
            100                 105                 110         
Ala Ala Leu Pro Ala Pro Glu Glu Ala Gly Pro Glu Arg Ile Val Ile
        115                 120                 125             
Ser His Ala Arg Pro Arg Ser Leu Arg Val Ser Trp Ala Pro Ala Leu
    130                 135                 140                 
Gly Ser Ala Ala Ala Leu Gly Tyr His Val Gln Phe Gly Pro Leu Arg
145                 150                 155                 160 
Gly Gly Glu Ala Gln Arg Val Glu Val Pro Ala Gly Arg Asn Cys Thr
                165                 170                 175     
Thr Leu Gln Gly Leu Ala Pro Gly Thr Ala Tyr Leu Val Thr Val Thr
            180                 185                 190         
Ala Ala Phe Arg Ser Gly Arg Glu Ser Ala Leu Ser Ala Lys Ala Cys
        195                 200                 205             
Thr Pro Asp Gly Pro Arg Pro Arg Pro Arg Pro Val Pro Arg Ala Pro
    210                 215                 220                 
Thr Pro Gly Thr Ala Ser Arg Glu Pro
225                 230             


<210> 6562
<211> 445
<212> PRT
<213> Homo sapiens

<400> 6562
Met Leu Pro Trp Thr Ala Leu Gly Leu Ala Leu Ser Leu Arg Leu Ala
 1               5                  10                  15      
Leu Ala Arg Ser Gly Ala Glu Arg Gly Pro Pro Ala Ser Ala Pro Arg
            20                  25                  30          
Gly Asp Leu Met Phe Leu Leu Asp Ser Ser Ala Ser Val Ser His Tyr
        35                  40                  45              
Glu Phe Ser Arg Val Arg Glu Phe Val Gly Gln Leu Val Ala Pro Leu
    50                  55                  60                  
Pro Leu Gly Thr Gly Ala Leu Arg Ala Ser Leu Val His Val Gly Ser
65                  70                  75                  80  
Arg Pro Tyr Thr Glu Phe Pro Phe Gly Gln His Ser Ser Gly Glu Ala
                85                  90                  95      
Ala Gln Asp Ala Val Arg Ala Ser Ala Gln Arg Met Gly Asp Thr His
            100                 105                 110         
Thr Gly Leu Ala Leu Val Tyr Ala Lys Glu Gln Leu Phe Ala Glu Ala
        115                 120                 125             
Ser Gly Ala Arg Pro Gly Val Pro Lys Val Leu Val Trp Val Thr Asp
    130                 135                 140                 
Gly Gly Ser Ser Asp Pro Val Gly Pro Pro Met Gln Glu Leu Lys Asp
145                 150                 155                 160 
Leu Gly Val Thr Val Phe Ile Val Ser Thr Gly Arg Gly Asn Phe Leu
                165                 170                 175     
Glu Leu Ser Ala Ala Ala Ser Ala Pro Ala Glu Lys His Leu His Phe
            180                 185                 190         
Val Asp Val Asp Asp Leu His Ile Ile Val Gln Glu Leu Arg Gly Ser
        195                 200                 205             
Ile Leu Asp Ala Met Arg Pro Gln Gln Leu His Ala Thr Glu Ile Thr
    210                 215                 220                 
Ser Ser Gly Phe Arg Leu Ala Trp Pro Pro Leu Leu Thr Ala Asp Ser
225                 230                 235                 240 
Gly Tyr Tyr Val Leu Glu Leu Val Pro Ser Ala Gln Pro Gly Ala Ala
                245                 250                 255     
Arg Arg Gln Gln Leu Pro Gly Asn Ala Thr Asp Trp Ile Trp Ala Gly
            260                 265                 270         
Leu Asp Pro Asp Thr Asp Tyr Asp Val Ala Leu Val Pro Glu Ser Asn
        275                 280                 285             
Val Arg Leu Leu Arg Pro Gln Ile Leu Arg Val Arg Thr Arg Pro Gly
    290                 295                 300                 
Glu Ala Gly Pro Gly Ala Ser Gly Pro Glu Ser Gly Ala Gly Pro Ala
305                 310                 315                 320 
Pro Thr Gln Leu Ala Ala Leu Pro Ala Pro Glu Glu Ala Gly Pro Glu
                325                 330                 335     
Arg Ile Val Ile Ser His Ala Arg Pro Arg Ser Leu Arg Val Ser Trp
            340                 345                 350         
Ala Pro Ala Leu Gly Ser Ala Ala Ala Leu Gly Tyr His Val Gln Phe
        355                 360                 365             
Gly Pro Leu Arg Gly Gly Glu Ala Gln Arg Val Glu Val Pro Ala Gly
    370                 375                 380                 
Arg Asn Cys Thr Thr Leu Gln Gly Leu Ala Pro Gly Thr Ala Tyr Leu
385                 390                 395                 400 
Val Thr Val Thr Ala Ala Phe Arg Ser Gly Arg Glu Ser Ala Leu Ser
                405                 410                 415     
Ala Lys Ala Cys Thr Pro Asp Gly Pro Arg Pro Arg Pro Arg Pro Val
            420                 425                 430         
Pro Arg Ala Pro Thr Pro Gly Thr Ala Ser Arg Glu Pro
        435                 440                 445 


<210> 6563
<211> 437
<212> PRT
<213> Homo sapiens

<400> 6563
Met Ser Pro Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu
 1               5                  10                  15      
Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val
            20                  25                  30          
Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser
        35                  40                  45              
Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser
    50                  55                  60                  
Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys
65                  70                  75                  80  
Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser
                85                  90                  95      
Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn
            100                 105                 110         
Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Asp Pro
        115                 120                 125             
Gly Ser Leu Arg Cys Pro Val Cys Leu Ser Met Glu Gly Cys Leu Glu
    130                 135                 140                 
Gly Thr Thr Glu Glu Ile Cys Pro Lys Gly Thr Thr His Cys Tyr Asp
145                 150                 155                 160 
Gly Leu Leu Arg Leu Arg Gly Gly Gly Ile Phe Ser Asn Leu Arg Val
                165                 170                 175     
Gln Gly Cys Met Pro Gln Pro Gly Cys Asn Leu Leu Asn Gly Thr Gln
            180                 185                 190         
Glu Ile Gly Pro Val Gly Met Thr Glu Asn Cys Asn Arg Lys Asp Phe
        195                 200                 205             
Leu Thr Cys His Arg Gly Thr Thr Ile Met Thr His Gly Asn Leu Ala
    210                 215                 220                 
Gln Glu Pro Thr Asp Trp Thr Thr Ser Asn Thr Glu Met Cys Glu Val
225                 230                 235                 240 
Gly Gln Val Cys Gln Glu Thr Leu Leu Leu Leu Asp Val Gly Leu Thr
                245                 250                 255     
Ser Thr Leu Val Gly Thr Lys Gly Cys Ser Thr Val Gly Ala Gln Asn
            260                 265                 270         
Ser Gln Lys Thr Thr Ile His Ser Ala Pro Pro Gly Val Leu Val Ala
        275                 280                 285             
Ser Tyr Thr His Phe Cys Ser Ser Asp Leu Cys Asn Ser Ala Ser Ser
    290                 295                 300                 
Ser Ser Val Leu Leu Asn Ser Leu Pro Pro Gln Ala Ala Pro Val Pro
305                 310                 315                 320 
Gly Asp Arg Gln Cys Pro Thr Cys Val Gln Pro Leu Gly Thr Cys Ser
                325                 330                 335     
Ser Gly Ser Pro Arg Met Thr Cys Pro Arg Gly Thr Thr His Cys Tyr
            340                 345                 350         
Asp Gly Tyr Ile His Leu Ser Gly Gly Gly Leu Ser Thr Lys Met Ser
        355                 360                 365             
Ile Gln Gly Cys Val Ala Gln Pro Ser Ser Phe Leu Leu Asn His Thr
    370                 375                 380                 
Arg Gln Ile Gly Ile Phe Ser Ala Arg Glu Lys Arg Asp Val Gln Pro
385                 390                 395                 400 
Pro Ala Ser Gln His Glu Gly Gly Gly Ala Glu Gly Leu Glu Ser Leu
                405                 410                 415     
Thr Trp Gly Val Gly Leu Ala Leu Ala Pro Ala Leu Trp Trp Gly Val
            420                 425                 430         
Val Cys Pro Ser Cys
        435         


<210> 6564
<211> 437
<212> PRT
<213> Homo sapiens

<400> 6564
Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu
 1               5                  10                  15      
Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val
            20                  25                  30          
Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser
        35                  40                  45              
Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser
    50                  55                  60                  
Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys
65                  70                  75                  80  
Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser
                85                  90                  95      
Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn
            100                 105                 110         
Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Asp Pro
        115                 120                 125             
Gly Ser Leu Arg Cys Pro Val Cys Leu Ser Met Glu Gly Cys Leu Glu
    130                 135                 140                 
Gly Thr Thr Glu Glu Ile Cys Pro Lys Gly Thr Thr His Cys Tyr Asp
145                 150                 155                 160 
Gly Leu Leu Arg Leu Arg Gly Gly Gly Ile Phe Ser Asn Leu Arg Val
                165                 170                 175     
Gln Gly Cys Met Pro Gln Pro Gly Cys Asn Leu Leu Asn Gly Thr Gln
            180                 185                 190         
Glu Ile Gly Pro Val Gly Met Thr Glu Asn Cys Asn Arg Lys Asp Phe
        195                 200                 205             
Leu Thr Cys His Arg Gly Thr Thr Ile Met Thr His Gly Asn Leu Ala
    210                 215                 220                 
Gln Glu Pro Thr Asp Trp Thr Thr Ser Asn Thr Glu Met Cys Glu Val
225                 230                 235                 240 
Gly Gln Val Cys Gln Glu Thr Leu Leu Leu Ile Asp Val Gly Leu Thr
                245                 250                 255     
Ser Thr Leu Val Gly Thr Lys Gly Cys Ser Thr Val Gly Ala Gln Asn
            260                 265                 270         
Ser Gln Lys Thr Thr Ile His Ser Ala Pro Pro Gly Val Leu Val Ala
        275                 280                 285             
Ser Tyr Thr His Phe Cys Ser Ser Asp Leu Cys Asn Ser Ala Ser Ser
    290                 295                 300                 
Ser Ser Val Leu Leu Asn Ser Leu Pro Pro Gln Ala Ala Pro Val Pro
305                 310                 315                 320 
Gly Asp Arg Gln Cys Pro Thr Cys Val Gln Pro Leu Gly Thr Cys Ser
                325                 330                 335     
Ser Gly Ser Pro Arg Met Thr Cys Pro Arg Gly Ala Thr His Cys Tyr
            340                 345                 350         
Asp Gly Tyr Ile His Leu Ser Gly Gly Gly Leu Ser Thr Lys Met Ser
        355                 360                 365             
Ile Gln Gly Cys Val Ala Gln Pro Ser Ser Phe Leu Leu Asn His Thr
    370                 375                 380                 
Arg Gln Ile Gly Ile Phe Ser Ala Arg Glu Lys Arg Asp Val Gln Pro
385                 390                 395                 400 
Pro Ala Ser Gln His Glu Gly Gly Gly Ala Glu Gly Leu Glu Ser Leu
                405                 410                 415     
Thr Trp Gly Val Gly Leu Ala Leu Ala Pro Ala Leu Trp Trp Gly Val
            420                 425                 430         
Val Cys Pro Ser Cys
        435         


<210> 6565
<211> 853
<212> PRT
<213> Homo sapiens

<400> 6565
Met Gly Thr Pro Arg Ala Gln His Pro Pro Pro Pro Gln Leu Leu Phe
 1               5                  10                  15      
Leu Ile Leu Leu Ser Cys Pro Trp Ile Gln Gly Leu Pro Leu Lys Glu
            20                  25                  30          
Glu Glu Ile Leu Pro Glu Pro Gly Ser Glu Thr Pro Thr Val Ala Ser
        35                  40                  45              
Glu Ala Leu Ala Glu Leu Leu His Gly Ala Leu Leu Arg Arg Gly Pro
    50                  55                  60                  
Glu Met Gly Tyr Leu Pro Gly Pro Pro Leu Gly Pro Glu Gly Gly Glu
65                  70                  75                  80  
Glu Glu Thr Thr Thr Thr Ile Ile Thr Thr Thr Thr Val Thr Thr Thr
                85                  90                  95      
Val Thr Ser Pro Val Leu Cys Asn Asn Asn Ile Ser Glu Gly Glu Gly
            100                 105                 110         
Tyr Val Glu Ser Pro Asp Leu Gly Ser Pro Val Ser Arg Thr Leu Gly
        115                 120                 125             
Leu Leu Asp Cys Thr Tyr Ser Ile His Val Tyr Pro Gly Tyr Gly Ile
    130                 135                 140                 
Glu Ile Gln Val Gln Thr Leu Asn Leu Ser Gln Glu Glu Glu Leu Leu
145                 150                 155                 160 
Val Leu Ala Gly Gly Gly Ser Pro Gly Leu Ala Pro Arg Leu Leu Ala
                165                 170                 175     
Asn Ser Ser Met Leu Gly Glu Gly Gln Val Leu Arg Ser Pro Thr Asn
            180                 185                 190         
Arg Leu Leu Leu His Phe Gln Ser Pro Arg Val Pro Arg Gly Gly Gly
        195                 200                 205             
Phe Arg Ile His Tyr Gln Ala Tyr Leu Leu Ser Cys Gly Phe Pro Pro
    210                 215                 220                 
Arg Pro Ala His Gly Asp Val Ser Val Thr Asp Leu His Pro Gly Gly
225                 230                 235                 240 
Thr Ala Thr Phe His Cys Asp Ser Gly Tyr Gln Leu Gln Gly Glu Glu
                245                 250                 255     
Thr Leu Ile Cys Leu Asn Gly Thr Arg Pro Ser Trp Asn Gly Glu Thr
            260                 265                 270         
Pro Ser Cys Met Ala Ser Cys Gly Gly Thr Ile His Asn Ala Thr Leu
        275                 280                 285             
Gly Arg Ile Val Ser Pro Glu Pro Gly Gly Ala Val Gly Pro Asn Leu
    290                 295                 300                 
Thr Cys Arg Trp Val Ile Glu Ala Ala Glu Gly Arg Arg Leu His Leu
305                 310                 315                 320 
His Phe Glu Arg Val Ser Leu Asp Glu Asp Asn Asp Arg Leu Met Val
                325                 330                 335     
Arg Ser Gly Gly Ser Pro Leu Ser Pro Val Ile Tyr Asp Ser Asp Met
            340                 345                 350         
Asp Asp Val Pro Glu Arg Gly Leu Ile Ser Asp Ala Gln Ser Leu Tyr
        355                 360                 365             
Val Glu Leu Leu Ser Glu Thr Pro Ala Asn Pro Leu Leu Leu Ser Leu
    370                 375                 380                 
Arg Phe Glu Ala Phe Glu Glu Asp Arg Cys Phe Ala Pro Phe Leu Ala
385                 390                 395                 400 
His Gly Asn Val Thr Thr Thr Asp Pro Glu Tyr Arg Pro Gly Ala Leu
                405                 410                 415     
Ala Thr Phe Ser Cys Leu Pro Gly Tyr Ala Leu Glu Pro Pro Gly Pro
            420                 425                 430         
Pro Asn Ala Ile Glu Cys Val Asp Pro Thr Glu Pro His Trp Asn Asp
        435                 440                 445             
Thr Glu Pro Ala Cys Lys Ala Met Cys Gly Gly Glu Leu Ser Glu Pro
    450                 455                 460                 
Ala Gly Val Val Leu Ser Pro Asp Trp Pro Gln Ser Tyr Ser Pro Gly
465                 470                 475                 480 
Gln Asp Cys Val Trp Gly Val His Val Gln Glu Glu Lys Arg Ile Leu
                485                 490                 495     
Leu Gln Val Glu Ile Leu Asn Val Arg Glu Gly Asp Met Leu Thr Leu
            500                 505                 510         
Phe Asp Gly Asp Gly Pro Ser Ala Arg Val Leu Ala Gln Leu Arg Gly
        515                 520                 525             
Pro Gln Pro Arg Arg Arg Leu Leu Ser Ser Gly Pro Asp Leu Thr Leu
    530                 535                 540                 
Gln Phe Gln Ala Pro Pro Gly Pro Pro Asn Pro Gly Leu Gly Gln Gly
545                 550                 555                 560 
Phe Val Leu His Phe Lys Glu Val Pro Arg Asn Asp Thr Cys Pro Glu
                565                 570                 575     
Leu Pro Pro Pro Glu Trp Gly Trp Arg Thr Ala Ser His Gly Asp Leu
            580                 585                 590         
Ile Arg Gly Thr Val Leu Thr Tyr Gln Cys Glu Pro Gly Tyr Glu Leu
        595                 600                 605             
Leu Gly Ser Asp Ile Leu Thr Cys Gln Trp Asp Leu Ser Trp Ser Ala
    610                 615                 620                 
Ala Pro Pro Ala Cys Gln Lys Ile Met Thr Cys Ala Asp Pro Gly Glu
625                 630                 635                 640 
Ile Ala Asn Gly His Arg Thr Ala Ser Asp Ala Gly Phe Pro Val Gly
                645                 650                 655     
Ser His Val Gln Tyr Arg Cys Leu Pro Gly Tyr Ser Leu Glu Gly Ala
            660                 665                 670         
Ala Met Leu Thr Cys Tyr Ser Arg Asp Thr Gly Thr Pro Lys Trp Ser
        675                 680                 685             
Asp Arg Val Pro Lys Cys Ala Leu Lys Tyr Glu Pro Cys Leu Asn Pro
    690                 695                 700                 
Gly Val Pro Glu Asn Gly Tyr Gln Thr Leu Tyr Lys His His Tyr Gln
705                 710                 715                 720 
Ala Gly Glu Ser Leu Arg Phe Phe Cys Tyr Glu Gly Phe Glu Leu Ile
                725                 730                 735     
Gly Glu Val Thr Ile Thr Cys Val Pro Gly His Pro Ser Gln Trp Thr
            740                 745                 750         
Ser Gln Pro Pro Leu Cys Lys Val Ala Tyr Glu Glu Leu Leu Asp Asn
        755                 760                 765             
Arg Lys Leu Glu Val Thr Gln Thr Thr Asp Pro Ser Arg Gln Leu Glu
    770                 775                 780                 
Gly Gly Asn Leu Ala Leu Ala Ile Leu Leu Pro Leu Gly Leu Val Ile
785                 790                 795                 800 
Val Leu Gly Ser Gly Val Tyr Ile Tyr Tyr Thr Lys Leu Gln Gly Lys
                805                 810                 815     
Ser Leu Phe Gly Phe Ser Gly Ser His Ser Tyr Ser Pro Ile Thr Val
            820                 825                 830         
Glu Ser Asp Phe Ser Asn Pro Leu Tyr Glu Ala Gly Asp Thr Arg Glu
        835                 840                 845             
Tyr Glu Val Ser Ile
    850             


<210> 6566
<211> 840
<212> PRT
<213> Homo sapiens

<400> 6566
Met Gly Thr Pro Arg Ala Gln His Pro Pro Pro Pro Gln Leu Leu Phe
 1               5                  10                  15      
Leu Ile Leu Leu Ser Cys Pro Trp Ile Gln Gly Leu Pro Leu Lys Glu
            20                  25                  30          
Glu Glu Ile Leu Pro Glu Pro Gly Ser Glu Thr Pro Thr Val Ala Ser
        35                  40                  45              
Glu Ala Leu Ala Glu Leu Leu His Gly Ala Leu Leu Arg Arg Gly Pro
    50                  55                  60                  
Glu Met Gly Tyr Leu Pro Gly Pro Pro Leu Gly Pro Glu Gly Gly Glu
65                  70                  75                  80  
Glu Glu Thr Thr Thr Thr Ile Ile Thr Thr Thr Thr Val Thr Thr Thr
                85                  90                  95      
Val Thr Ser Pro Val Leu Cys Asn Asn Asn Ile Ser Glu Gly Glu Gly
            100                 105                 110         
Tyr Val Glu Ser Pro Asp Leu Gly Ser Pro Val Ser Arg Thr Leu Gly
        115                 120                 125             
Leu Leu Asp Cys Thr Tyr Ser Ile His Val Tyr Pro Gly Tyr Gly Ile
    130                 135                 140                 
Glu Ile Gln Val Gln Thr Leu Asn Leu Ser Gln Glu Glu Glu Leu Leu
145                 150                 155                 160 
Val Leu Ala Gly Gly Gly Ser Pro Gly Leu Ala Pro Arg Leu Leu Ala
                165                 170                 175     
Asn Ser Ser Met Leu Gly Glu Gly Gln Val Leu Arg Ser Pro Thr Asn
            180                 185                 190         
Arg Leu Leu Leu His Phe Gln Ser Pro Arg Val Pro Arg Gly Gly Gly
        195                 200                 205             
Phe Arg Ile His Tyr Gln Ala Tyr Leu Leu Ser Cys Gly Phe Pro Pro
    210                 215                 220                 
Arg Pro Ala His Gly Asp Val Ser Val Thr Asp Leu His Pro Gly Gly
225                 230                 235                 240 
Thr Ala Thr Phe His Cys Asp Ser Gly Tyr Gln Leu Gln Gly Glu Glu
                245                 250                 255     
Thr Leu Ile Cys Leu Asn Gly Thr Arg Pro Ser Trp Asn Gly Glu Thr
            260                 265                 270         
Pro Ser Cys Met Ala Ser Cys Gly Gly Thr Ile His Asn Ala Thr Leu
        275                 280                 285             
Gly Arg Ile Val Ser Pro Glu Pro Gly Gly Ala Val Gly Pro Asn Leu
    290                 295                 300                 
Thr Cys Arg Trp Val Ile Glu Ala Ala Glu Gly Arg Arg Leu His Leu
305                 310                 315                 320 
His Phe Glu Arg Val Ser Leu Asp Glu Asp Asn Asp Arg Leu Met Val
                325                 330                 335     
Arg Ser Gly Gly Ser Pro Leu Ser Pro Val Ile Tyr Asp Ser Asp Met
            340                 345                 350         
Asp Asp Val Pro Glu Arg Gly Leu Ile Ser Asp Ala Gln Ser Leu Tyr
        355                 360                 365             
Val Glu Leu Leu Ser Glu Thr Pro Ala Asn Pro Leu Leu Leu Ser Leu
    370                 375                 380                 
Arg Phe Glu Ala Phe Glu Glu Asp Arg Cys Phe Ala Pro Phe Leu Ala
385                 390                 395                 400 
His Gly Asn Val Thr Thr Thr Asp Pro Glu Tyr Arg Pro Gly Ala Leu
                405                 410                 415     
Ala Thr Phe Ser Cys Leu Pro Gly Tyr Ala Leu Glu Pro Pro Gly Pro
            420                 425                 430         
Pro Asn Ala Ile Glu Cys Val Asp Pro Thr Glu Pro His Trp Asn Asp
        435                 440                 445             
Thr Glu Pro Ala Cys Lys Ala Met Cys Gly Gly Glu Leu Ser Glu Pro
    450                 455                 460                 
Ala Gly Val Val Leu Ser Pro Asp Trp Pro Gln Ser Tyr Ser Pro Gly
465                 470                 475                 480 
Gln Asp Cys Val Trp Gly Val His Val Gln Glu Glu Lys Arg Ile Leu
                485                 490                 495     
Leu Gln Val Glu Ile Leu Asn Val Arg Glu Gly Asp Met Leu Thr Leu
            500                 505                 510         
Phe Asp Gly Asp Gly Pro Ser Ala Arg Val Leu Ala Gln Leu Arg Gly
        515                 520                 525             
Pro Gln Pro Arg Arg Arg Leu Leu Ser Ser Gly Pro Asp Leu Thr Leu
    530                 535                 540                 
Gln Phe Gln Ala Pro Pro Gly Pro Pro Asn Pro Gly Leu Gly Gln Gly
545                 550                 555                 560 
Phe Val Leu His Phe Lys Glu Val Pro Arg Asn Asp Thr Cys Pro Glu
                565                 570                 575     
Leu Pro Pro Pro Glu Trp Gly Trp Arg Thr Ala Ser His Gly Asp Leu
            580                 585                 590         
Ile Arg Gly Thr Val Leu Thr Tyr Gln Cys Glu Pro Gly Tyr Glu Leu
        595                 600                 605             
Leu Gly Ser Asp Ile Leu Thr Cys Gln Trp Asp Leu Ser Trp Ser Ala
    610                 615                 620                 
Ala Pro Pro Ala Cys Gln Lys Ile Met Thr Cys Ala Asp Pro Gly Glu
625                 630                 635                 640 
Ile Ala Asn Gly His Arg Thr Ala Ser Asp Ala Gly Phe Pro Val Gly
                645                 650                 655     
Ser His Val Gln Tyr Arg Cys Leu Pro Gly Tyr Ser Leu Glu Gly Ala
            660                 665                 670         
Ala Met Leu Thr Cys Tyr Ser Arg Asp Thr Gly Thr Pro Lys Trp Ser
        675                 680                 685             
Asp Arg Val Pro Lys Cys Ala Leu Lys Tyr Glu Pro Cys Leu Asn Pro
    690                 695                 700                 
Gly Val Pro Glu Asn Gly Tyr Gln Thr Leu Tyr Lys His His Tyr Gln
705                 710                 715                 720 
Ala Gly Glu Ser Leu Arg Phe Phe Cys Tyr Glu Gly Phe Glu Leu Ile
                725                 730                 735     
Gly Glu Val Thr Ile Thr Cys Val Pro Gly His Pro Ser Gln Trp Thr
            740                 745                 750         
Ser Gln Pro Pro Leu Cys Lys Val Thr Gln Thr Thr Asp Pro Ser Arg
        755                 760                 765             
Gln Leu Glu Gly Gly Asn Leu Ala Leu Ala Ile Leu Leu Pro Leu Gly
    770                 775                 780                 
Leu Val Ile Val Leu Gly Ser Gly Val Tyr Ile Tyr Tyr Thr Lys Leu
785                 790                 795                 800 
Gln Gly Lys Ser Leu Phe Gly Phe Ser Gly Ser His Ser Tyr Ser Pro
                805                 810                 815     
Ile Thr Val Glu Ser Asp Phe Ser Asn Pro Leu Tyr Glu Ala Gly Asp
            820                 825                 830         
Thr Arg Glu Tyr Glu Val Ser Ile
        835                 840 


<210> 6567
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 6567
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15      
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Gly
            20                  25                  30          
Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu
        35                  40                  45              
Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu
    50                  55                  60                  
Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser
65                  70                  75                  80  
Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr
                85                  90                  95      
Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp
            100                 105                 110         
Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser
        115                 120                 125             
Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser
    130                 135                 140                 
Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro
145                 150                 155                 160 
Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala
                165                 170                 175     
Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser
            180                 185                 190         
Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly
        195                 200                 205             
Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro
    210                 215                 220                 
Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn
225                 230                 235                 240 
Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val
                245                 250                 255     
Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr
            260                 265                 270         
Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala
        275                 280                 285             
Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe
    290                 295                 300                 
Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys
305                 310                 315                 320 
Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile
                325                 330                 335     
Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile
            340                 345                 350         
Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu
        355                 360                 365             
Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys
    370                 375                 380                 
Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser
385                 390                 395                 400 
Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser
                405                 410                 415     
Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys
            420                 425                 430         
Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys
        435                 440                 445             
Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys
    450                 455                 460                 
Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser
465                 470                 475                 480 
Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp
                485                 490                 495     
Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro
            500                 505                 510         
His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg
        515                 520                 525             
Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr
    530                 535                 540                 
Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro
545                 550                 555                 560 
Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala
                565                 570                 575     
Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu
            580                 585                 590         
Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys
        595                 600                 605             
Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln
    610                 615                 620                 
Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr
625                 630                 635                 640 
Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln
                645                 650                 655     
Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys
            660                 665                 670         
Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp
        675                 680                 685             
Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn
    690                 695                 700                 
Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr
705                 710                 715                 720 
Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg
                725                 730                 735     
Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys
            740                 745                 750         
Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu
        755                 760                 765             
Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His
    770                 775                 780                 
Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys
785                 790                 795                 800 
Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser
                805                 810                 815     
Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu
            820                 825                 830         
Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val
        835                 840                 845             
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile
    850                 855                 860                 
Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr
865                 870                 875                 880 
Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val
                885                 890                 895     
Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln
            900                 905                 910         
Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His
        915                 920                 925             
Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala
    930                 935                 940                 
Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile
945                 950                 955                 960 
Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile
                965                 970                 975     
Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser
            980                 985                 990         
Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp
        995                 1000                1005            
Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr
    1010                1015                1020                
Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr
1025                1030                1035                1040
Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile
                1045                1050                1055    
Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln
            1060                1065                1070        
Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu
        1075                1080                1085            
Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu
    1090                1095                1100                
Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr
1105                1110                1115                1120
Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile
                1125                1130                1135    
Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser
            1140                1145                1150        
Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg
        1155                1160                1165            
Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu
    1170                1175                1180                
Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys
1185                1190                1195                1200
Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr
                1205                1210                1215    
Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly
            1220                1225                1230        
Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn
        1235                1240                1245            
Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly
    1250                1255                1260                
Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu
1265                1270                1275                1280
Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala
                1285                1290                1295    
Ser Pro Ala Leu Asn Gln Gly Ser
            1300                


<210> 6568
<211> 1143
<212> PRT
<213> Homo sapiens

<400> 6568
Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe Leu Asp
 1               5                  10                  15      
Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro Thr Asp
            20                  25                  30          
Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser
        35                  40                  45              
Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro Thr
    50                  55                  60                  
Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys
65                  70                  75                  80  
Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val Glu
                85                  90                  95      
Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr Glu
            100                 105                 110         
Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala Pro
        115                 120                 125             
Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe Gln
    130                 135                 140                 
Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys Leu
145                 150                 155                 160 
Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr
                165                 170                 175     
Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile Lys
            180                 185                 190         
Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu Ile
        195                 200                 205             
Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr
    210                 215                 220                 
Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu
225                 230                 235                 240 
Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe
                245                 250                 255     
His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu
            260                 265                 270         
Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro
        275                 280                 285             
Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys Val
    290                 295                 300                 
Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser Ala
305                 310                 315                 320 
Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp Asn
                325                 330                 335     
Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro His
            340                 345                 350         
Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg Asn
        355                 360                 365             
Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr Ser
    370                 375                 380                 
Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro Gly
385                 390                 395                 400 
Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala Leu
                405                 410                 415     
Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu Leu
            420                 425                 430         
Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys Asn
        435                 440                 445             
Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln Leu
    450                 455                 460                 
Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr Lys
465                 470                 475                 480 
Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln Ser
                485                 490                 495     
Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys Pro
            500                 505                 510         
Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp Tyr
        515                 520                 525             
Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn Tyr
    530                 535                 540                 
Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr Ile
545                 550                 555                 560 
Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg Met
                565                 570                 575     
Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys Glu
            580                 585                 590         
Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu Glu
        595                 600                 605             
Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His Lys
    610                 615                 620                 
Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys Lys
625                 630                 635                 640 
Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser Trp
                645                 650                 655     
Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu Arg
            660                 665                 670         
Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val Val
        675                 680                 685             
His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile Asp
    690                 695                 700                 
Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr Gly
705                 710                 715                 720 
Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val Glu
                725                 730                 735     
Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln Phe
            740                 745                 750         
Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His Asn
        755                 760                 765             
Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala Glu
    770                 775                 780                 
Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile Gly
785                 790                 795                 800 
Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile Pro
                805                 810                 815     
Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser Lys
            820                 825                 830         
Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp Ser
        835                 840                 845             
Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr Trp
    850                 855                 860                 
Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr Ile
865                 870                 875                 880 
Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile Val
                885                 890                 895     
Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln Tyr
            900                 905                 910         
Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu Lys
        915                 920                 925             
Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu Arg
    930                 935                 940                 
His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr Thr
945                 950                 955                 960 
Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile Ser
                965                 970                 975     
Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu
            980                 985                 990         
Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp
        995                 1000                1005            
Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu
    1010                1015                1020                
Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys Ala
1025                1030                1035                1040
Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln
                1045                1050                1055    
Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln
            1060                1065                1070        
Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu
        1075                1080                1085            
Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala
    1090                1095                1100                
Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro
1105                1110                1115                1120
Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser
                1125                1130                1135    
Pro Ala Leu Asn Gln Gly Ser
            1140            


<210> 6569
<211> 180
<212> PRT
<213> Homo sapiens

<400> 6569
Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu Ala
 1               5                  10                  15      
Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser Ala
            20                  25                  30          
Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly Cys
        35                  40                  45              
Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe Ser
    50                  55                  60                  
Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val His
65                  70                  75                  80  
Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr Leu
                85                  90                  95      
Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val Glu
            100                 105                 110         
Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser His
        115                 120                 125             
Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser Gln
    130                 135                 140                 
Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly Gln
145                 150                 155                 160 
Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu Glu
                165                 170                 175     
Gly Ala Glu Asp
            180 


<210> 6570
<211> 1445
<212> PRT
<213> Homo sapiens

<400> 6570
Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys
 1               5                  10                  15      
Thr Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Thr Ala
            20                  25                  30          
Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Thr Ile Gly Val Glu Leu
        35                  40                  45              
Leu Glu His Cys Pro Ser Gln Val Thr Val Lys Ala Glu Leu Leu Lys
    50                  55                  60                  
Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val Phe
65                  70                  75                  80  
Glu Lys Gly Ser Phe Lys Thr Leu Thr Leu Pro Ser Leu Pro Leu Asn
                85                  90                  95      
Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Thr Gly Arg Thr Gln Asp
            100                 105                 110         
Glu Ile Leu Phe Ser Asn Ser Thr Arg Leu Ser Phe Glu Thr Lys Arg
        115                 120                 125             
Ile Ser Val Phe Ile Gln Thr Asp Lys Ala Leu Tyr Lys Pro Lys Gln
    130                 135                 140                 
Glu Val Lys Phe Arg Ile Val Thr Leu Phe Ser Asp Phe Lys Pro Tyr
145                 150                 155                 160 
Lys Thr Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile
                165                 170                 175     
Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Thr
            180                 185                 190         
Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val
        195                 200                 205             
Gln Val Asn Asp Gln Thr Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr
    210                 215                 220                 
Val Leu Pro Lys Phe Glu Val Thr Leu Gln Thr Pro Leu Tyr Cys Ser
225                 230                 235                 240 
Met Asn Ser Lys His Leu Asn Gly Thr Ile Thr Ala Lys Tyr Thr Tyr
                245                 250                 255     
Gly Lys Pro Val Lys Gly Asp Val Thr Leu Thr Phe Leu Pro Leu Ser
            260                 265                 270         
Phe Trp Gly Lys Lys Lys Asn Ile Thr Lys Thr Phe Lys Ile Asn Gly
        275                 280                 285             
Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp
    290                 295                 300                 
Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro
305                 310                 315                 320 
Val Glu Ile Leu Thr Thr Val Thr Glu Ser Val Thr Gly Ile Ser Arg
                325                 330                 335     
Asn Val Ser Thr Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu
            340                 345                 350         
Phe Phe Asp Tyr Thr Thr Val Leu Lys Pro Ser Leu Asn Phe Thr Ala
        355                 360                 365             
Thr Val Lys Val Thr Arg Ala Asp Gly Asn Gln Leu Thr Leu Glu Glu
    370                 375                 380                 
Arg Arg Asn Asn Val Val Ile Thr Val Thr Gln Arg Asn Tyr Thr Glu
385                 390                 395                 400 
Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln
                405                 410                 415     
Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys Ile Glu Phe
            420                 425                 430         
Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu
        435                 440                 445             
Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser
    450                 455                 460                 
Lys Thr Tyr Ile Gln Leu Lys Thr Arg Asp Glu Asn Ile Lys Val Gly
465                 470                 475                 480 
Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu
                485                 490                 495     
Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln
            500                 505                 510         
Asn Ser Thr Met Phe Ser Leu Thr Pro Glu Asn Ser Trp Thr Pro Lys
        515                 520                 525             
Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser
    530                 535                 540                 
Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys
545                 550                 555                 560 
Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu
                565                 570                 575     
Arg Ile Ser Val Thr Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val
            580                 585                 590         
Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Thr Met Glu
        595                 600                 605             
Asn Val Val His Glu Leu Glu Leu Tyr Asn Thr Gly Tyr Tyr Leu Gly
    610                 615                 620                 
Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val
625                 630                 635                 640 
Leu Thr Asp Ala Asn Leu Thr Lys Asp Tyr Ile Asp Gly Val Tyr Asp
                645                 650                 655     
Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile
            660                 665                 670         
Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys
        675                 680                 685             
His Phe Pro Glu Thr Trp Ile Trp Leu Asp Thr Asn Met Gly Tyr Arg
    690                 695                 700                 
Ile Tyr Gln Glu Phe Glu Val Thr Val Pro Asp Ser Ile Thr Ser Trp
705                 710                 715                 720 
Val Ala Thr Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Thr
                725                 730                 735     
Thr Thr Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu
            740                 745                 750         
Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile
        755                 760                 765             
Thr Ile Phe Asn Tyr Leu Lys Asp Ala Thr Glu Val Lys Val Ile Ile
    770                 775                 780                 
Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Thr Ser Asn Glu Ile Asn
785                 790                 795                 800 
Ala Thr Gly His Gln Gln Thr Leu Leu Val Pro Ser Glu Asp Gly Ala
                805                 810                 815     
Thr Val Leu Phe Pro Ile Arg Pro Thr His Leu Gly Glu Ile Pro Ile
            820                 825                 830         
Thr Val Thr Ala Leu Ser Pro Thr Ala Ser Asp Ala Val Thr Gln Met
        835                 840                 845             
Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile
    850                 855                 860                 
Leu Leu Asp Leu Thr Asp Asn Arg Leu Gln Ser Thr Leu Lys Thr Leu
865                 870                 875                 880 
Ser Phe Ser Phe Pro Pro Asn Thr Val Thr Gly Ser Glu Arg Val Gln
                885                 890                 895     
Ile Thr Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala
            900                 905                 910         
Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn
        915                 920                 925             
Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Thr Lys Lys Lys Gln
    930                 935                 940                 
Leu Thr Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly
945                 950                 955                 960 
Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala
                965                 970                 975     
Phe Gly Asn Tyr Asp Pro Ser Gly Ser Thr Trp Leu Ser Ala Phe Val
            980                 985                 990         
Leu Arg Cys Phe Leu Glu Ala Asp Pro Tyr Ile Asp Ile Asp Gln Asn
        995                 1000                1005            
Val Leu His Arg Thr Tyr Thr Trp Leu Lys Gly His Gln Lys Ser Asn
    1010                1015                1020                
Gly Glu Phe Trp Asp Pro Gly Arg Val Ile His Ser Glu Leu Gln Gly
1025                1030                1035                1040
Gly Asn Lys Ser Pro Val Thr Leu Thr Ala Tyr Ile Val Thr Ser Leu
                1045                1050                1055    
Leu Gly Tyr Arg Lys Tyr Gln Pro Asn Ile Asp Val Gln Glu Ser Ile
            1060                1065                1070        
His Phe Leu Glu Ser Glu Phe Ser Arg Gly Ile Ser Asp Asn Tyr Thr
        1075                1080                1085            
Leu Ala Leu Ile Thr Tyr Ala Leu Ser Ser Val Gly Ser Pro Lys Ala
    1090                1095                1100                
Lys Glu Ala Leu Asn Met Leu Thr Trp Arg Ala Glu Gln Glu Gly Gly
1105                1110                1115                1120
Met Gln Phe Trp Val Ser Ser Glu Ser Lys Leu Ser Asp Ser Trp Gln
                1125                1130                1135    
Pro Arg Ser Leu Asp Ile Glu Val Ala Ala Tyr Ala Leu Leu Ser His
            1140                1145                1150        
Phe Leu Gln Phe Gln Thr Ser Glu Gly Ile Pro Ile Met Arg Trp Leu
        1155                1160                1165            
Ser Arg Gln Arg Asn Ser Leu Gly Gly Phe Ala Ser Thr Gln Asp Thr
    1170                1175                1180                
Thr Val Ala Leu Lys Ala Leu Ser Glu Phe Ala Ala Leu Met Asn Thr
1185                1190                1195                1200
Glu Arg Thr Asn Ile Gln Val Thr Val Thr Gly Pro Ser Ser Pro Ser
                1205                1210                1215    
Pro Val Lys Phe Leu Ile Asp Thr His Asn Arg Leu Leu Leu Gln Thr
            1220                1225                1230        
Ala Glu Leu Ala Val Val Gln Pro Met Ala Val Asn Ile Ser Ala Asn
        1235                1240                1245            
Gly Phe Gly Phe Ala Ile Cys Gln Leu Asn Val Val Tyr Asn Val Lys
    1250                1255                1260                
Ala Ser Gly Ser Ser Arg Arg Arg Arg Ser Ile Gln Asn Gln Glu Ala
1265                1270                1275                1280
Phe Asp Leu Asp Val Ala Val Lys Glu Asn Lys Asp Asp Leu Asn His
                1285                1290                1295    
Val Asp Leu Asn Val Cys Thr Ser Phe Ser Gly Pro Gly Arg Ser Gly
            1300                1305                1310        
Met Ala Leu Met Glu Val Asn Leu Leu Ser Gly Phe Met Val Pro Ser
        1315                1320                1325            
Glu Ala Ile Ser Leu Ser Glu Thr Val Lys Lys Val Glu Tyr Asp His
    1330                1335                1340                
Gly Lys Leu Asn Leu Tyr Leu Asp Ser Val Asn Glu Thr Gln Phe Cys
1345                1350                1355                1360
Val Asn Ile Pro Ala Val Arg Asn Phe Lys Val Ser Asn Thr Gln Asp
                1365                1370                1375    
Ala Ser Val Ser Ile Val Asp Tyr Tyr Glu Pro Arg Arg Gln Ala Val
            1380                1385                1390        
Arg Ser Tyr Asn Ser Glu Val Lys Leu Ser Ser Cys Asp Leu Cys Ser
        1395                1400                1405            
Asp Val Gln Gly Cys Arg Pro Cys Glu Asp Gly Ala Ser Gly Ser His
    1410                1415                1420                
His His Ser Ser Val Ile Phe Ile Phe Cys Phe Lys Leu Leu Tyr Phe
1425                1430                1435                1440
Met Glu Leu Trp Leu
                1445


<210> 6571
<211> 422
<212> PRT
<213> Homo sapiens

<400> 6571
Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala Val Asp Ala Ala Ile
 1               5                  10                  15      
Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala His Ser Met Gly Ile
            20                  25                  30          
Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser Thr Thr Arg Lys Ala
        35                  40                  45              
Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg Leu Ala Phe Ala Thr
    50                  55                  60                  
Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly Gly Leu Ser Val Ala
65                  70                  75                  80  
Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala His Gln Arg His Gly
                85                  90                  95      
Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser Ile Gln Leu Ala Arg
            100                 105                 110         
Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala Ala Leu Glu Asn Lys
        115                 120                 125             
Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys Glu Val Phe Cys Arg
    130                 135                 140                 
Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu Thr Leu Pro Gln Leu
145                 150                 155                 160 
Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly Ala Gln Ala Phe Tyr
                165                 170                 175     
Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp Ile Gln Ala Ala Gly
            180                 185                 190         
Glu Trp Val Thr Ser Gly Ala Trp Val Arg Asn Ser Ala Val Glu Thr
        195                 200                 205             
Leu Ser Cys Ser Pro Glu Leu Trp Gly Pro Pro Val Leu Pro Glu Pro
    210                 215                 220                 
Ala Gly Ser Ser Trp Trp Arg Arg Val Arg Tyr Asn Phe Ser Arg Glu
225                 230                 235                 240 
Ser Val Glu Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val
                245                 250                 255     
Glu Ala Phe Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro
            260                 265                 270         
Lys Phe Val Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe
        275                 280                 285             
Phe Ala Ala Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro
    290                 295                 300                 
Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr
305                 310                 315                 320 
Ala His Leu Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr
                325                 330                 335     
Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser
            340                 345                 350         
Gly Ile Leu Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile
        355                 360                 365             
Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro
    370                 375                 380                 
Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln
385                 390                 395                 400 
Asp Gly Gln Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile
                405                 410                 415     
Thr Thr Ala Thr Ala Leu
            420         


<210> 6572
<211> 366
<212> PRT
<213> Homo sapiens

<400> 6572
Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val
 1               5                  10                  15      
Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu
            20                  25                  30          
Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys
        35                  40                  45              
Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala
    50                  55                  60                  
Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala
65                  70                  75                  80  
His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser
                85                  90                  95      
Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg
            100                 105                 110         
Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly
        115                 120                 125             
Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala
    130                 135                 140                 
His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser
145                 150                 155                 160 
Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala
                165                 170                 175     
Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys
            180                 185                 190         
Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu
        195                 200                 205             
Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly
    210                 215                 220                 
Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp
225                 230                 235                 240 
Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr
                245                 250                 255     
Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Ala
            260                 265                 270         
Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu
        275                 280                 285             
Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu
    290                 295                 300                 
Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe
305                 310                 315                 320 
Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val
                325                 330                 335     
Asp Val Thr Glu Ala Ser Ser Gly Val Ser Ala Gly Gly Pro Gln His
            340                 345                 350         
Asp Leu Arg Val Leu Arg Cys Pro Ala Pro Gly Pro Asp Leu
        355                 360                 365     


<210> 6573
<211> 569
<212> PRT
<213> Homo sapiens

<400> 6573
Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val
 1               5                  10                  15      
Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu
            20                  25                  30          
Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys
        35                  40                  45              
Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala
    50                  55                  60                  
Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala
65                  70                  75                  80  
His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser
                85                  90                  95      
Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg
            100                 105                 110         
Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly
        115                 120                 125             
Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala
    130                 135                 140                 
His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser
145                 150                 155                 160 
Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala
                165                 170                 175     
Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys
            180                 185                 190         
Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu
        195                 200                 205             
Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly
    210                 215                 220                 
Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp
225                 230                 235                 240 
Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr
                245                 250                 255     
Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Ala
            260                 265                 270         
Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu
        275                 280                 285             
Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu
    290                 295                 300                 
Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe
305                 310                 315                 320 
Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val
                325                 330                 335     
Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala
            340                 345                 350         
Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr
        355                 360                 365             
Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu
    370                 375                 380                 
Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile
385                 390                 395                 400 
Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu
                405                 410                 415     
Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu
            420                 425                 430         
Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln
        435                 440                 445             
Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly Gln
    450                 455                 460                 
Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile Thr Thr Ala
465                 470                 475                 480 
Thr Ala Leu Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val Lys
                485                 490                 495     
Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Val
            500                 505                 510         
Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu Glu
        515                 520                 525             
Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val Val
    530                 535                 540                 
Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp Ser
545                 550                 555                 560 
Arg Lys Gly Gly Glu Pro Ala Gly Tyr
                565                 


<210> 6574
<211> 439
<212> PRT
<213> Homo sapiens

<400> 6574
Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr
 1               5                  10                  15      
Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp
            20                  25                  30          
Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys
        35                  40                  45              
Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu
    50                  55                  60                  
Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys
65                  70                  75                  80  
Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys
                85                  90                  95      
Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn
            100                 105                 110         
Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn
        115                 120                 125             
Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu
    130                 135                 140                 
Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys
145                 150                 155                 160 
Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys
                165                 170                 175     
Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser
            180                 185                 190         
Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Val Gln His Leu
        195                 200                 205             
Ile Tyr Lys Asp Cys Ser Asp Tyr Tyr Ala Ile Gly Lys Arg Ser Ser
    210                 215                 220                 
Glu Thr Tyr Arg Val Thr Pro Asp Pro Lys Asn Ser Ser Phe Glu Val
225                 230                 235                 240 
Tyr Cys Asp Met Glu Thr Met Gly Gly Gly Trp Thr Val Leu Gln Ala
                245                 250                 255     
Arg Leu Asp Gly Ser Thr Asn Phe Thr Arg Thr Trp Gln Asp Tyr Lys
            260                 265                 270         
Ala Gly Phe Gly Asn Leu Arg Arg Glu Phe Trp Leu Gly Asn Asp Lys
        275                 280                 285             
Ile His Leu Leu Thr Lys Ser Lys Glu Met Ile Leu Arg Ile Asp Leu
    290                 295                 300                 
Glu Asp Phe Asn Gly Val Glu Leu Tyr Ala Leu Tyr Asp Gln Phe Tyr
305                 310                 315                 320 
Val Ala Asn Glu Phe Leu Lys Tyr Arg Leu His Val Gly Asn Tyr Asn
                325                 330                 335     
Gly Thr Ala Gly Asp Ala Leu Arg Phe Asn Lys His Tyr Asn His Asp
            340                 345                 350         
Leu Lys Phe Phe Thr Thr Pro Asp Lys Asp Asn Asp Arg Tyr Pro Ser
        355                 360                 365             
Gly Asn Cys Gly Leu Tyr Tyr Ser Ser Gly Trp Trp Phe Asp Ala Cys
    370                 375                 380                 
Leu Ser Ala Asn Leu Asn Gly Lys Tyr Tyr His Gln Lys Tyr Arg Gly
385                 390                 395                 400 
Val Arg Asn Gly Ile Phe Trp Gly Thr Trp Pro Gly Val Ser Glu Ala
                405                 410                 415     
His Pro Gly Gly Tyr Lys Ser Ser Phe Lys Glu Ala Lys Met Met Ile
            420                 425                 430         
Arg Pro Lys His Phe Lys Pro
        435                 


<210> 6575
<211> 609
<212> PRT
<213> Homo sapiens

<400> 6575
Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala
 1               5                  10                  15      
Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr
            20                  25                  30          
Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met
        35                  40                  45              
Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile
    50                  55                  60                  
Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg
65                  70                  75                  80  
Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser
                85                  90                  95      
Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly
            100                 105                 110         
Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln
        115                 120                 125             
Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser
    130                 135                 140                 
Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys
145                 150                 155                 160 
Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His
                165                 170                 175     
Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp
            180                 185                 190         
Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro
        195                 200                 205             
Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala
    210                 215                 220                 
Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu
225                 230                 235                 240 
Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu
                245                 250                 255     
Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly
            260                 265                 270         
Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu
        275                 280                 285             
Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn
    290                 295                 300                 
Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln
305                 310                 315                 320 
Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu
                325                 330                 335     
Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro
            340                 345                 350         
Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val
        355                 360                 365             
Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala
    370                 375                 380                 
Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr
385                 390                 395                 400 
Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln
                405                 410                 415     
Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe
            420                 425                 430         
Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe
        435                 440                 445             
Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala
    450                 455                 460                 
Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn
465                 470                 475                 480 
Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp
                485                 490                 495     
Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu
            500                 505                 510         
Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu
        515                 520                 525             
Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys
    530                 535                 540                 
His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser
545                 550                 555                 560 
Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe
                565                 570                 575     
Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser
            580                 585                 590         
Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln
        595                 600                 605             
Asp
    


<210> 6576
<211> 608
<212> PRT
<213> Homo sapiens

<400> 6576
Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala Glu
 1               5                  10                  15      
Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr Ser
            20                  25                  30          
Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met Phe
        35                  40                  45              
Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile Gln
    50                  55                  60                  
Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg Asp
65                  70                  75                  80  
Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser Val
                85                  90                  95      
Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly Ala
            100                 105                 110         
Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln Lys
        115                 120                 125             
Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser Glu
    130                 135                 140                 
Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys Met
145                 150                 155                 160 
Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His Gly
                165                 170                 175     
Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp Leu
            180                 185                 190         
Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro Gly
        195                 200                 205             
Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala Glu
    210                 215                 220                 
Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu Asp
225                 230                 235                 240 
Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu Ser
                245                 250                 255     
Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly Ile
            260                 265                 270         
Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu Tyr
        275                 280                 285             
Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn Thr
    290                 295                 300                 
Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln Ile
305                 310                 315                 320 
Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu Leu
                325                 330                 335     
Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro Leu
            340                 345                 350         
Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val Tyr
        355                 360                 365             
Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala Leu
    370                 375                 380                 
Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr Thr
385                 390                 395                 400 
Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln Glu
                405                 410                 415     
Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe Gln
            420                 425                 430         
Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe Thr
        435                 440                 445             
Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala Ile
    450                 455                 460                 
Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn Pro
465                 470                 475                 480 
Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp Leu
                485                 490                 495     
Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu Ala
            500                 505                 510         
Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu Val
        515                 520                 525             
Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys His
    530                 535                 540                 
Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser Glu
545                 550                 555                 560 
Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe Thr
                565                 570                 575     
Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser Gly
            580                 585                 590         
Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln Asp
        595                 600                 605             


<210> 6577
<211> 1358
<212> PRT
<213> Homo sapiens

<400> 6577
Met Ile Glu Pro Ser Glu Asp Ser Phe Glu Thr Met Met Glu His Lys
 1               5                  10                  15      
Asn Pro Ser Ser Lys Gln Met Glu Ser Ser Glu Gly Ser Ser Asn Thr
            20                  25                  30          
Thr Glu Ala Thr Ser Gly Ser Gly Val Arg Gly Glu Ala Gly Pro Ala
        35                  40                  45              
Ser Gly Pro Ala Gln Glu Lys Lys Glu Pro Pro Ser Gly Pro Leu Gln
    50                  55                  60                  
Glu Met Glu Glu Leu Pro Thr Asp Leu Leu Gln Asp Met Glu Glu Pro
65                  70                  75                  80  
Ser Ser Gly Pro Arg Lys Glu Ile Glu Asp Pro Pro Asn Asp Leu Leu
                85                  90                  95      
Gln Asp Leu Glu Glu Ser Cys Asn Gly Ser His Gln Ala Arg Gly Asp
            100                 105                 110         
Pro Leu Ser Gly Ala Ser Asp Arg Met Lys Glu Ala Ser Val Asn Pro
        115                 120                 125             
Ser Gly Ala Arg Glu Glu Gln Glu Ala His Thr Asp Leu Lys Glu Ser
    130                 135                 140                 
Gly Arg Glu Glu Thr Pro Gln Glu Gln Asn Gln Thr Glu His Ser Thr
145                 150                 155                 160 
Ala Glu Leu Met Ala Met Val Arg Ser Ile Ile Ser Leu Tyr Phe Arg
                165                 170                 175     
Met Gln Asp Leu Lys Glu Gln Gln Arg Val Ala Glu Glu Ile Leu Ile
            180                 185                 190         
Lys Gly Ile Asn Ala Gly Gln Leu Pro Ala Pro Lys His Phe Ser Gly
        195                 200                 205             
Asp Arg Arg Glu Phe His Glu Phe Ile Val Leu Cys Gln Leu Thr Leu
    210                 215                 220                 
Gln Ser Tyr Pro Arg Met Phe Tyr Asn Asp Arg Leu Arg Val Gly Tyr
225                 230                 235                 240 
Val Ile Asn His Leu Ser Gly Leu Ala Leu Glu Trp Ala Lys Ala Leu
                245                 250                 255     
Leu Gln Glu Asn Ser Pro Leu Ile Gly Asp Phe Pro Ala Phe Leu Glu
            260                 265                 270         
Ala Met Ser Glu Val Phe Glu Tyr Arg Gln Ala Leu Arg Val Ala Glu
        275                 280                 285             
Glu Ala Met Phe Thr Ile Arg Gln Gly Gly Arg Ser Ala Thr Glu Tyr
    290                 295                 300                 
Ile Asp Glu Phe Gln Ser Leu Val Pro Ile Leu Gly Trp Pro Asp Glu
305                 310                 315                 320 
Val Leu Gln Ala His Leu Cys Gln Gly Leu Asn Glu Glu Ile Arg His
                325                 330                 335     
Tyr Leu Phe Arg Val Pro Gln Pro Asp Ser Leu Asp Ser Leu Ile Val
            340                 345                 350         
Leu Ile Leu Gln Ile Glu Glu Lys Leu Ala Glu Arg Arg Ala Met Leu
        355                 360                 365             
Arg Leu Pro Pro Glu Ala Arg Pro Arg Asn Leu Thr Trp Ile Asp Ser
    370                 375                 380                 
Pro Ala Pro Glu Arg Trp Met Val Ser Ser Trp Leu Pro Ser Glu Val
385                 390                 395                 400 
His Pro Asp Ile Asn Arg Ala His Leu Phe Leu Leu Leu Met Val Arg
                405                 410                 415     
Val Asn Pro Tyr His Ser Val Ala Val Gln Ala Leu Val Asp Ser Gly
            420                 425                 430         
Ala Asp Gly Asn Phe Met Asp Glu Lys Phe Ala Gln Glu His Tyr Val
        435                 440                 445             
Glu Leu Tyr Glu Lys Pro Tyr Pro Gln Pro Val Gln Ser Val Asp Gly
    450                 455                 460                 
Ser Leu Ile Gly Asn Glu Pro Val Trp Leu Tyr Thr Glu Pro Leu Val
465                 470                 475                 480 
Cys Ile His Gln Asn His Gln Glu Ser Ile Glu Phe Asp Ile Val Pro
                485                 490                 495     
Ser Pro Asn Phe Ser Val Val Leu Gly Ile Arg Trp Leu Arg Val His
            500                 505                 510         
Ala Pro Glu Val Asp Trp Ile Lys Gly Arg Cys Thr Phe His Ser Pro
        515                 520                 525             
Tyr Cys Leu Lys Asn Cys Phe Arg Pro Pro Pro Pro Cys Ile Ala Leu
    530                 535                 540                 
Glu Arg His Gly Met Ser Leu Leu Pro Gly Leu Pro His Pro Tyr Ser
545                 550                 555                 560 
Asp Leu Ala Asp Val Phe Asn Pro Lys Glu Ala Asp Asp Glu Thr Ser
                565                 570                 575     
Asp Gln Pro Ser Ser Asp Gly Ser Asp Asp Leu Ser Glu Ser Glu Pro
            580                 585                 590         
Ser Glu Leu Gln Gln Ala Gly Asp Ser Asp His Ser Glu Thr Phe Tyr
        595                 600                 605             
Glu Cys Pro Ser Thr Ala Pro Trp Glu Pro Val Gly Ala Arg Met Gln
    610                 615                 620                 
Glu Arg Ala Arg Leu Gln Glu Glu Tyr Trp Asp Leu Gln Asp Met Leu
625                 630                 635                 640 
Thr Asn Arg Gln Asp Tyr Ile Gln Met Ile Pro Glu Leu Phe Asp Gln
                645                 650                 655     
Leu His Gly Ala Glu Trp Phe Thr Lys Leu Glu Leu Arg Gly Thr Ile
            660                 665                 670         
Val Glu Glu Ser Val Asn Gly His Arg Thr Glu Asp Val Trp Lys Ala
        675                 680                 685             
Ala Phe Gly Leu Glu Leu Glu Glu Met Lys Ser Tyr Gln Pro Phe Ala
    690                 695                 700                 
Leu Ser Pro Asp Pro Ile Ile Pro Gln Asn Val Ile His Phe Ile Leu
705                 710                 715                 720 
Lys Asp Met Leu Gly Phe Phe Val Leu Ser Tyr Gly Gln Glu Val Leu
                725                 730                 735     
Ile Tyr Ser Met Ser Gln Glu Glu His Leu His His Val Arg Gln Val
            740                 745                 750         
Leu Val Arg Phe Arg His His Asn Val Tyr Cys Ser Leu Asp Lys Ser
        755                 760                 765             
Gln Phe His Arg Gln Thr Val Glu Phe Leu Gly Phe Val Val Thr Pro
    770                 775                 780                 
Lys Gly Val Lys Leu Asn Lys Asn Val Met Thr Ile Ile Thr Gly Tyr
785                 790                 795                 800 
Pro Thr Pro Gly Ser Lys Leu Ser Leu Arg Asn Phe Ile Glu Phe Val
                805                 810                 815     
Phe Pro Tyr Arg His Phe Val Glu Arg Phe Ser Ile Ile Ala Glu Pro
            820                 825                 830         
Leu Val Arg Gln Leu Leu Ser Ser Tyr Gln Phe Tyr Trp Gly Val Glu
        835                 840                 845             
Glu Gln Glu Ala Phe Glu Cys Leu Lys Arg Ala Phe Arg Lys Ala Pro
    850                 855                 860                 
Leu Leu His His Pro Lys Pro Gln Asn Pro Phe Tyr Leu Glu Thr Gly
865                 870                 875                 880 
Val Thr Gly Thr Ala Leu His Ala Ser Leu Ile Gln Ile Asp Asp Gln
                885                 890                 895     
Thr Gly Lys Arg Ala Cys Cys Ala Phe Tyr Ser Arg Asn Ile Ser Pro
            900                 905                 910         
Ile Glu Val Glu Tyr Ser Gln Ala Glu Met Lys Ile Leu Pro Ile Arg
        915                 920                 925             
Ala Ala Phe Met Val Trp Cys Arg Tyr Leu Glu Asn Thr Glu Glu Pro
    930                 935                 940                 
Ile Met Ile Leu Leu Asn Thr Glu Asp Leu Ala Ser Leu Asn Asn Asp
945                 950                 955                 960 
Arg Leu Thr Val Leu Leu Pro Gly His Trp Val Phe Phe Phe Ser His
                965                 970                 975     
Phe Asn Phe Asp Val Met Glu Leu Pro Glu Gln Asp Gly Gly Arg Ala
            980                 985                 990         
Leu Pro Pro Val Arg Asn Leu Arg Trp Arg Arg Ala Phe Gln Arg Asn
        995                 1000                1005            
Thr Ala Ala Arg Gln Thr Leu Leu Leu Ala Ser Arg Gly Phe Pro Arg
    1010                1015                1020                
Asp Pro Ser Thr Glu Ser Gly Glu Glu Glu Asn Glu Glu Gln Asp Glu
1025                1030                1035                1040
Leu Asn Glu Gln Ile Leu Arg Gln Glu Leu Leu Ala Met Ile Pro Ile
                1045                1050                1055    
Asp Gln Ile Leu Asn Ser Phe Leu Ala His Phe Ser Met Ala Gln Ile
            1060                1065                1070        
Arg Ala Val Ile Leu His Phe Phe Arg Gly Leu Leu Tyr Trp Lys Asn
        1075                1080                1085            
Thr Leu Ala Leu Ala Ala Ile Leu Val Leu Leu Arg Val Arg Gln Cys
    1090                1095                1100                
Leu Ser Leu Arg Pro Ala Pro Ala Met Arg Val Ala Arg Pro Gln Pro
1105                1110                1115                1120
Gln Arg Ser Leu Arg Leu Ile Leu Asp Ser Ser Leu Ile Ala Gly Ser
                1125                1130                1135    
Ser Ile Thr Thr Ala Ile Thr Gln Leu Leu Thr Gln Met Pro Ala Leu
            1140                1145                1150        
Val Gly Ala Asn Thr Ile Pro Ala Gln Glu Leu Ala Glu Leu Phe Leu
        1155                1160                1165            
Gly Pro Gly Arg Trp Gln Arg Asn Ala Leu His Ser Gln Ala His Arg
    1170                1175                1180                
Gly Leu Gln Phe Thr Pro Gly Phe Trp Leu Thr Leu Cys Glu Phe Phe
1185                1190                1195                1200
Gly Val Arg Val Thr Pro Gln Glu Gly His Leu Pro Ala Leu Arg Gln
                1205                1210                1215    
Asn Arg Tyr Leu Glu Leu His Val Val Gly Asp Glu Asp Val Val Leu
            1220                1225                1230        
Arg Glu Ala Leu Gln Asp Asp Leu Gln Arg Tyr Arg Gln Cys Gly Leu
        1235                1240                1245            
His Asp Gly Leu Gln Asp Thr Ser Gln Asp Lys Gln Asp Asn Asp Val
    1250                1255                1260                
Gln Glu Ala Pro Pro Ser His Thr Ala Ala Thr His Pro Pro Arg Pro
1265                1270                1275                1280
Arg His Leu Met Asp Pro Gln Val Leu Glu Phe Leu Gly Ser Arg Leu
                1285                1290                1295    
Leu His Ile His Ser Ala Asp Gly Gln Leu His Leu Leu Ser Arg Glu
            1300                1305                1310        
Gln Ala Ala Arg Ala Leu Ser Gln Phe Leu Thr Leu Ile Tyr Arg Arg
        1315                1320                1325            
Ala Leu Pro Ile Pro Ala Trp Glu Ser Gln Pro Arg Glu Gln Ala Arg
    1330                1335                1340                
Leu Glu Glu Leu Pro Asp Glu Asp Glu Asp Ala Asn Leu Asp
1345                1350                1355            


<210> 6578
<211> 2124
<212> PRT
<213> Homo sapiens

<400> 6578
Met Arg Ala Ser Leu Leu His Pro Pro Ser Gln Gln Phe Val Glu Glu
 1               5                  10                  15      
Asp Ala Val Gly Gly Asp Gly Arg Arg Ser Cys Pro Cys Ser His Trp
            20                  25                  30          
Val Lys Glu Ala Glu Thr Thr Asp Met Thr Glu Ser Ser Met Lys Lys
        35                  40                  45              
Leu Ala Ser Thr Leu Leu Asp Ala Ile Thr Asp Lys Asp Pro Leu Val
    50                  55                  60                  
Gln Glu Gln Val Cys Ser Ala Leu Cys Ser Leu Gly Glu Ala Arg Pro
65                  70                  75                  80  
Val Glu Thr Leu Arg Ala Cys Glu Glu Tyr Leu Arg Gln His Asp Lys
                85                  90                  95      
Leu Ala His Pro Tyr Arg Ala Ala Val Leu Arg Ala Met Glu Arg Val
            100                 105                 110         
Leu Ser Ser Arg Ala Ser Glu Leu Asp Lys Asp Thr Ala Ser Thr Ile
        115                 120                 125             
Ile Leu Leu Ala Ser Ser Glu Met Thr Lys Thr Lys Asp Leu Val Trp
    130                 135                 140                 
Asp Trp Gln Gln Ala Ala Ser Gly Val Leu Val Ala Val Gly Arg Gln
145                 150                 155                 160 
Phe Ile Ser Lys Val Met Glu Glu Leu Leu Arg Arg Leu His Pro Gly
                165                 170                 175     
Thr Leu Pro His Cys Ala Val Leu His Thr Leu Ala Ser Leu Ser Val
            180                 185                 190         
Ala Asn Ala Phe Gly Val Val Pro Phe Leu Pro Ser Val Leu Ser Ser
        195                 200                 205             
Leu Leu Pro Val Leu Gly Val Ala Lys Gln Asp Thr Val Arg Val Ala
    210                 215                 220                 
Phe Cys Ser Gly Asp Leu Arg Leu Leu Trp Ala Leu Pro Cys Trp His
225                 230                 235                 240 
Phe Pro Pro Cys Val Lys His Met Gly Ser Ala Ser Glu Asp Ser Met
                245                 250                 255     
Gly Pro Pro Arg Val Gly Arg Val Leu Pro Thr Thr Asn Gly Thr Phe
            260                 265                 270         
Pro Val Cys Ile Trp Arg Gly Trp Trp Ser Cys Trp Leu Glu Gln Pro
        275                 280                 285             
Gly Ala Arg Gly Ser Arg Ile Asn Arg Thr Gln Arg Cys Gln Leu Leu
    290                 295                 300                 
Cys Glu Ser Ile Ile Thr Asp Ser Gly Glu Leu Leu Met Arg Val Pro
305                 310                 315                 320 
Gln Gly Leu Ser Gln Pro Leu Gly Leu Arg Leu Glu Val Leu Val Thr
                325                 330                 335     
Leu Lys Ala Val Leu Glu Gly Gly Gln Trp Pro His Glu Gly Asp Glu
            340                 345                 350         
Gly Tyr Ser His Leu Pro Leu Ala Gly Phe Val Ala Leu Gln Arg Phe
        355                 360                 365             
Ser Glu Gly Ala Leu Glu Tyr Leu Ala Asn Leu Asp Arg Ala Pro Asp
    370                 375                 380                 
Pro Thr Val Arg Lys Asp Ala Phe Ala Thr Asp Ile Phe Ser Ala Tyr
385                 390                 395                 400 
Asp Val Leu Phe His Gln Trp Leu Gln Ser Arg Glu Ala Lys Leu Arg
                405                 410                 415     
Leu Ala Val Val Glu Ala Leu Gly Pro Met Ser His Leu Leu Pro Ser
            420                 425                 430         
Glu Arg Leu Glu Glu Gln Leu Pro Lys Leu Leu Pro Gly Ile Leu Ala
        435                 440                 445             
Leu Tyr Lys Lys His Ala Glu Thr Phe Tyr Leu Ser Lys Ala Leu Ile
    450                 455                 460                 
Asp Leu Ser Gln Phe Gly Arg Leu Glu Val Gly Leu Thr Ala Ser Ser
465                 470                 475                 480 
Pro Tyr Pro Glu Gln Ser Leu Gly Gln Ile Leu Glu Ala Ala Val Ser
                485                 490                 495     
Val Gly Ser Arg Thr Leu Glu Thr Gln Leu Asp Ala Leu Leu Ala Ala
            500                 505                 510         
Leu His Ser Gln Ile Cys Val Pro Val Glu Ser Ser Ser Pro Leu Val
        515                 520                 525             
Met Ser Asn Gln Lys Glu Val Leu Arg Cys Phe Thr Val Leu Gly Gly
    530                 535                 540                 
Leu Trp Leu Leu Ala Leu Val Thr Cys Gln Pro Pro Met Thr His Leu
545                 550                 555                 560 
Glu Val Pro Cys Ile Leu Ser Pro Pro Pro Leu Asp Ala Val Pro Met
                565                 570                 575     
Pro Cys Thr Gly Pro His Ser His Pro Gly Gly Ala Ala Asp Ala Cys
            580                 585                 590         
Ser Ser Pro Asp Arg Leu Leu Ala Phe Leu Leu Pro Arg Leu Asp Thr
        595                 600                 605             
Ser Asn Glu Arg Thr Arg Val Gly Thr Leu Gln Val Val Arg His Val
    610                 615                 620                 
Ile Asn Ser Ala Ala Ala Gln Met Glu Asp Lys Lys Pro Phe Ile Leu
625                 630                 635                 640 
Ser Ser Met Arg Leu Pro Leu Leu Asp Thr Asn Ser Lys Val Lys Arg
                645                 650                 655     
Ala Val Val Gln Val Ile Ser Ala Met Ala His His Gly Tyr Leu Glu
            660                 665                 670         
Gln Pro Gly Gly Glu Ala Met Ile Glu Tyr Ile Val Gln Gln Cys Ala
        675                 680                 685             
Leu Pro Pro Glu Gln Glu Ala Leu Ser Pro Val Cys Val Leu Thr Phe
    690                 695                 700                 
Val Phe Leu Val Glu Tyr Val Leu Thr Val Arg Tyr Gln Pro Glu Lys
705                 710                 715                 720 
Pro Gly Pro Gly Ser Lys Asp Pro Lys Ala Asp Ser Val Arg Ala Ile
                725                 730                 735     
Ser Val Arg Thr Leu Tyr Leu Val Ser Thr Thr Val Asp Arg Met Ser
            740                 745                 750         
His Val Leu Trp Pro Tyr Leu Leu Gln Phe Leu Thr Pro Val Arg Phe
        755                 760                 765             
Thr Gly Ala Leu Thr Pro Leu Cys Arg Ser Leu Val His Leu Ala Gln
    770                 775                 780                 
Lys Arg Gln Glu Ala Gly Ala Asp Ala Phe Leu Ile Gln Tyr Asp Ala
785                 790                 795                 800 
His Ala Ser Leu Pro Ser Pro Tyr Ala Val Thr Gly Arg Leu Leu Val
                805                 810                 815     
Val Ser Ser Ser Pro Tyr Leu Gly Asp Gly Arg Gly Ala Ala Ala Leu
            820                 825                 830         
Arg Leu Leu Ser Val Leu His Pro Asn Ile His Pro Leu Leu Gly Gln
        835                 840                 845             
His Trp Glu Thr Thr Val Pro Leu Leu Leu Gly Tyr Leu Asp Glu His
    850                 855                 860                 
Thr Glu Glu Thr Leu Pro Gln Glu Glu Trp Glu Glu Lys Leu Leu Met
865                 870                 875                 880 
Val Arg Ala Gly Val Arg Pro Ile Leu Gly Leu Lys Phe Leu Arg Asp
                885                 890                 895     
Thr Leu Ala Ile Ile Ser Asp Asn Ala Trp Ile Cys Gln Leu Ser Leu
            900                 905                 910         
Glu Leu Cys Arg Gln Leu Pro Cys Tyr Asp Glu Ala Pro Gln Glu Lys
        915                 920                 925             
Asn Phe Leu Tyr Lys Cys Ile Gly Thr Thr Leu Gly Ala Ala Ser Ser
    930                 935                 940                 
Lys Glu Val Val Arg Lys His Leu Gln Glu Leu Leu Glu Thr Ala Arg
945                 950                 955                 960 
Tyr Gln Glu Glu Ala Glu Arg Glu Gly Leu Ala Cys Cys Phe Gly Ile
                965                 970                 975     
Cys Ala Ile Ser His Leu Glu Asp Thr Leu Ala Gln Leu Glu Asp Phe
            980                 985                 990         
Val Arg Ser Glu Val Phe Arg Lys Ser Ile Gly Ile Leu Asn Ile Phe
        995                 1000                1005            
Lys Asp Arg Ser Glu Asn Glu Val Glu Lys Val Lys Ser Ala Leu Ile
    1010                1015                1020                
Leu Cys Tyr Gly His Val Ala Ala Arg Ala Pro Arg Glu Leu Val Leu
1025                1030                1035                1040
Ala Lys Val Glu Ser Asp Ile Leu Arg Asn Ile Cys Gln His Phe Ser
                1045                1050                1055    
Thr Lys Val Leu Gly Ile Lys Val Glu Thr Lys Glu Ala Phe Glu Ser
            1060                1065                1070        
Ile Thr Arg Ala Pro Ser Leu Ala Trp Ala Leu Asp Gly Ser Gly Lys
        1075                1080                1085            
Lys Gly Gly Val Cys Ala Ser Glu Gly Pro Gly Arg Gly Leu Ser Pro
    1090                1095                1100                
Pro Arg Glu Phe Ser Gln Pro His Pro Ser Gln Asp Ser Trp Asn Leu
1105                1110                1115                1120
Leu Trp Leu Cys Ser Pro Val Leu Met Gly Ala Val Pro Pro Arg Thr
                1125                1130                1135    
Pro Asp Pro Ala Leu Lys Leu Cys Leu Val Gln Ser Val Cys Met Val
            1140                1145                1150        
Ser Arg Ala Ile Cys Ser Ser Thr Gln Ala Gly Ser Phe His Phe Thr
        1155                1160                1165            
Arg Lys Ala Glu Leu Val Ala Gln Met Met Glu Phe Ile Arg Ala Glu
    1170                1175                1180                
Pro Pro Asp Ser Leu Arg Thr Pro Ile Arg Lys Lys Ala Met Leu Thr
1185                1190                1195                1200
Cys Thr Tyr Leu Pro Ala Leu Asp Glu Gln Ala Arg Ala Asp Val Ile
                1205                1210                1215    
His Gly Cys Leu His Ser Ile Met Ala Leu Leu Pro Glu Pro Lys Glu
            1220                1225                1230        
Glu Asp Gly Gly Cys Gln Lys Ser Leu Tyr Leu Glu Thr Leu His Ala
        1235                1240                1245            
Leu Glu Asp Leu Leu Thr Ser Leu Leu Gln Arg Asn Met Thr Pro Gln
    1250                1255                1260                
Gly Leu Gln Ile Met Ile Glu His Leu Ser Pro Trp Ile Lys Ser Pro
1265                1270                1275                1280
Arg Gly His Glu Arg Ala Arg Ala Leu Gly Leu Ser Ala Leu Leu Leu
                1285                1290                1295    
Arg Tyr Phe Leu Glu His Leu Arg Val Ser Ala Leu Val Pro Phe His
            1300                1305                1310        
Asn Leu Gly Leu Leu Ile Gly Leu Phe Ser Pro Arg Cys Ala Asp Leu
        1315                1320                1325            
Trp Pro Ala Thr Arg Gln Glu Ala Val Asp Cys Val Tyr Ser Leu Leu
    1330                1335                1340                
Tyr Leu Gln Leu Gly Tyr Glu Gly Phe Ser Arg Asp Tyr Arg Asp Asp
1345                1350                1355                1360
Val Ala Glu Arg Leu Leu Ser Leu Lys Asp Gly Leu Val His Pro Asp
                1365                1370                1375    
Pro Ala Ile Leu Phe His Thr Cys His Ser Val Gly Gln Ile Ile Ala
            1380                1385                1390        
Lys Arg Leu Pro Pro Asp Gln Leu Ile Ser Leu Leu Leu Thr Met Phe
        1395                1400                1405            
Glu Ala Leu Gly Asp Pro Glu Lys Asn Cys Ser Arg Ala Ala Thr Val
    1410                1415                1420                
Met Ile Asn Cys Leu Leu Gln Glu Arg Gly Gly Val Leu Gln Glu Lys
1425                1430                1435                1440
Val Pro Glu Ile Val Ser Val Leu Arg Ser Lys Leu Gln Glu Ala Gln
                1445                1450                1455    
Gly Glu His Val Leu Pro Ala Ala Gln His Ser Val Tyr Leu Leu Ala
            1460                1465                1470        
Thr Gln His Cys Ala Ala Val Val Ser Ser Leu Leu Gly Ser Pro Leu
        1475                1480                1485            
Pro Leu Asp Ser His Thr Cys Met Leu Trp Arg Ala Leu Ala Val Glu
    1490                1495                1500                
Pro Arg Leu Ala Ala Gln Val Leu Gly Leu Leu Leu Glu Lys Met Ser
1505                1510                1515                1520
Arg Asp Val Pro Phe Lys Glu Ser Arg Ala Phe Leu Leu Gly Arg Thr
                1525                1530                1535    
Pro Asp Arg Val Ala Thr Leu Leu Pro Leu Ser Ala Thr Cys Ala Leu
            1540                1545                1550        
Phe Glu Val Met Ser Thr Pro Ala Ala Gly Pro Ala Val Leu Glu Leu
        1555                1560                1565            
Tyr Pro Gln Leu Phe Val Val Leu Leu Leu Arg Val Ser Cys Thr Val
    1570                1575                1580                
Gly Val Gln Leu Pro Arg Asn Leu Gln Ala Gln Glu Arg Arg Gly Ala
1585                1590                1595                1600
Ser Pro Ala Leu Ala Thr Arg Asn Leu Glu Pro Cys Arg Ala Gly Ser
                1605                1610                1615    
Pro Leu Gly Thr Gln Ala Thr Trp Ala Gln Arg Ser Gly Pro Asn Thr
            1620                1625                1630        
Gly Thr Met Gly Leu Gln Ala Phe Pro Glu Leu Pro Ser Arg Thr Ser
        1635                1640                1645            
Asp Leu Gly Glu Gly Thr Arg Glu Arg Glu Glu Pro Gly Asp Thr His
    1650                1655                1660                
Gln Gly Leu Cys Glu Gly Leu Ala Leu Leu Leu Ala His Ser Thr Ser
1665                1670                1675                1680
Gln His Thr Arg Gly Pro Val Gly His Leu Ala Gly Gly Asp Gln Gly
                1685                1690                1695    
Ser Gly Thr Val Thr Thr Thr Ser Gly His His Thr Ala Arg Ala Ala
            1700                1705                1710        
Arg Gly Leu Ser Ala Phe Gly Pro Gly Ala Pro Glu Asp Glu Ala Leu
        1715                1720                1725            
Trp Gly Gln Arg Ser Lys Gly Gly Gly Gly Leu Ser Val Ser Ser Ala
    1730                1735                1740                
Val Asp Thr Leu Arg Ser Met Leu Leu Arg Ser Gly Ser Glu Asp Val
1745                1750                1755                1760
Val Gln Arg Met Asp Leu Glu Gly Gly Trp Glu Leu Leu Arg Thr Ser
                1765                1770                1775    
Ala Gly His Glu Glu Gly Ala Thr Arg Leu Ala Arg Ala Met Ala Glu
            1780                1785                1790        
His Ala Gly Pro Arg Leu Pro Leu Val Leu Lys Thr Leu Ala Cys Thr
        1795                1800                1805            
His Ser Ser Ala Tyr Glu Asn Gln Arg Val Thr Thr Thr Ala Phe Leu
    1810                1815                1820                
Ala Glu Leu Leu Asn Ser Asn Val Ala Asn Asp Leu Met Leu Leu Asp
1825                1830                1835                1840
Ser Leu Leu Glu Ser Leu Ala Ala Arg Gln Lys Asp Thr Cys Ala Ser
                1845                1850                1855    
Val Arg Arg Leu Val Leu Arg Gly Leu Ala Asn Leu Ala Ser Gly Cys
            1860                1865                1870        
Pro Asp Lys Val Arg Thr His Gly Pro Gln Leu Leu Thr Ala Met Ile
        1875                1880                1885            
Gly Gly Leu Asp Asp Gly Asp Asn Pro His Ser Pro Val Ala Leu Glu
    1890                1895                1900                
Ala Met Leu Gly Leu Ala Arg Leu Val His Leu Val Glu Ser Trp Asp
1905                1910                1915                1920
Leu Arg Ser Gly Leu Leu His Val Ala Ile Arg Ile Arg Pro Phe Phe
                1925                1930                1935    
Asp Ser Glu Lys Met Glu Phe Arg Thr Ala Ser Ile Arg Leu Phe Gly
            1940                1945                1950        
His Leu Asn Lys Val Cys His Gly Asp Cys Glu Asp Val Phe Leu Asp
        1955                1960                1965            
Gln Val Val Gly Gly Leu Ala Pro Leu Leu Leu His Leu Gln Asp Pro
    1970                1975                1980                
Gln Ala Thr Val Ala Ser Val Ser Ser Gln Gly Ala Cys Arg Phe Ala
1985                1990                1995                2000
Leu Arg Met Cys Gly Pro Asn Leu Ala Cys Glu Glu Leu Ser Ala Ala
                2005                2010                2015    
Phe Gln Lys His Leu Gln Glu Gly Arg Ala Leu His Phe Gly Glu Phe
            2020                2025                2030        
Leu Asn Thr Thr Cys Lys His Leu Met His His Phe Pro Asp Leu Leu
        2035                2040                2045            
Gly Arg Leu Leu Thr Thr Cys Leu Phe Tyr Phe Lys Ser Ser Trp Glu
    2050                2055                2060                
Asn Val Arg Ala Ala Ala Pro Leu Phe Thr Gly Phe Leu Val Leu His
2065                2070                2075                2080
Ser Glu Pro Arg Gln Gln Pro Gln Val Asp Leu Asp Gln Leu Ile Ala
                2085                2090                2095    
Ala Leu Gln Ile Leu Leu Lys Asp Pro Ala Pro Glu Val Arg Thr Arg
            2100                2105                2110        
Ala Ala Glu Ala Leu Gly Arg Leu Val Lys Leu Ala
        2115                2120                


<210> 6579
<211> 548
<212> PRT
<213> Homo sapiens

<400> 6579
Met Gly Phe Val Leu Gly Thr Gln Ala Leu Gln Cys Leu Pro Ser Trp
 1               5                  10                  15      
Gly Gln Gly Trp Ala Ser Leu Val Gly Asn Asp Cys Gly Pro His Arg
            20                  25                  30          
Phe Ser Ser Ser Thr Glu Gln Ser Ser Ala Ser Arg Leu Met Arg Arg
        35                  40                  45              
His Lys Arg Arg Arg Arg Lys Gln Lys Val Ser Arg Ile Glu Arg Ser
    50                  55                  60                  
Ser Ser Phe Ser Ser Ile Thr Asp Ser Thr Met Ser Leu Asn Ile Ile
65                  70                  75                  80  
Thr Val Thr Leu Asn Met Glu Lys Tyr Asn Phe Leu Gly Ile Ser Ile
                85                  90                  95      
Val Gly Gln Ser Asn Glu Arg Gly Asp Gly Gly Ile Tyr Ile Gly Ser
            100                 105                 110         
Ile Met Lys Gly Gly Ala Val Ala Ala Asp Gly Arg Ile Glu Pro Gly
        115                 120                 125             
Asp Met Leu Leu Gln Val Asn Glu Ile Asn Phe Glu Asn Met Ser Asn
    130                 135                 140                 
Asp Asp Ala Val Arg Val Leu Arg Glu Ile Val His Lys Pro Gly Pro
145                 150                 155                 160 
Ile Thr Leu Thr Val Ala Lys Cys Trp Asp Pro Ser Pro Arg Gly Cys
                165                 170                 175     
Phe Thr Leu Pro Arg Ser Glu Pro Ile Arg Pro Ile Asp Pro Ala Ala
            180                 185                 190         
Trp Val Ser His Thr Ala Ala Met Thr Gly Thr Phe Pro Ala Tyr Gly
        195                 200                 205             
Met Ser Pro Ser Leu Ser Thr Ile Thr Ser Thr Ser Ser Ser Ile Thr
    210                 215                 220                 
Ser Ser Ile Pro Asp Thr Glu Arg Leu Asp Asp Phe His Leu Ser Ile
225                 230                 235                 240 
His Ser Asp Met Ala Ala Ile Val Lys Ala Met Ala Ser Pro Glu Ser
                245                 250                 255     
Gly Leu Glu Val Arg Asp Arg Met Trp Leu Lys Ile Thr Ile Pro Asn
            260                 265                 270         
Ala Phe Ile Gly Ser Asp Val Val Asp Trp Leu Tyr His Asn Val Glu
        275                 280                 285             
Gly Phe Thr Asp Arg Arg Glu Ala Arg Lys Tyr Ala Ser Asn Leu Leu
    290                 295                 300                 
Lys Ala Gly Phe Ile Arg His Thr Val Asn Lys Ile Thr Phe Ser Glu
305                 310                 315                 320 
Gln Cys Tyr Tyr Ile Phe Gly Asp Leu Cys Gly Asn Met Ala Asn Leu
                325                 330                 335     
Ser Leu His Asp His Asp Gly Ser Ser Gly Ala Ser Asp Gln Asp Thr
            340                 345                 350         
Leu Ala Pro Leu Pro His Pro Gly Ala Ala Pro Trp Pro Met Ala Phe
        355                 360                 365             
Pro Tyr Gln Tyr Pro Pro Pro Pro His Pro Tyr Asn Pro His Pro Gly
    370                 375                 380                 
Phe Pro Glu Leu Gly Tyr Ser Tyr Gly Gly Gly Ser Ala Ser Ser Gln
385                 390                 395                 400 
His Ser Glu Gly Ser Arg Ser Ser Gly Ser Asn Arg Ser Gly Ser Asp
                405                 410                 415     
Arg Arg Lys Glu Lys Asp Pro Lys Ala Gly Asp Ser Lys Ser Gly Gly
            420                 425                 430         
Ser Gly Ser Glu Ser Asp His Thr Thr Arg Ser Ser Leu Arg Gly Pro
        435                 440                 445             
Arg Glu Arg Ala Pro Ser Glu Arg Ser Gly Pro Ala Ala Ser Glu His
    450                 455                 460                 
Ser His Arg Ser His His Ser Leu Ala Ser Ser Leu Arg Ser His His
465                 470                 475                 480 
Thr His Pro Ser Tyr Gly Pro Pro Gly Val Pro Pro Leu Tyr Gly Pro
                485                 490                 495     
Pro Met Leu Met Met Pro Pro Pro Pro Ala Ala Met Gly Pro Pro Gly
            500                 505                 510         
Ala Pro Pro Gly Arg Asp Leu Ala Ser Val Pro Pro Glu Leu Thr Ala
        515                 520                 525             
Ser Arg Gln Ser Phe Arg Met Ala Met Gly Asn Pro Ser Glu Phe Phe
    530                 535                 540                 
Val Asp Val Met
545             


<210> 6580
<211> 716
<212> PRT
<213> Homo sapiens

<400> 6580
Met Gly Glu Thr Lys Ile Ile Tyr His Leu Asp Gly Gln Glu Thr Pro
 1               5                  10                  15      
Tyr Leu Val Lys Leu Pro Leu Pro Ala Glu Arg Val Thr Leu Ala Asp
            20                  25                  30          
Phe Lys Gly Val Leu Gln Arg Pro Ser Tyr Lys Phe Phe Phe Lys Ser
        35                  40                  45              
Met Asp Asp Asp Phe Gly Val Val Lys Glu Glu Ile Ser Asp Asp Asn
    50                  55                  60                  
Ala Lys Leu Pro Cys Phe Asn Gly Arg Val Val Ser Trp Leu Val Ser
65                  70                  75                  80  
Ala Glu Gly Ser His Pro Asp Pro Ala Pro Phe Cys Ala Asp Asn Pro
                85                  90                  95      
Ser Glu Leu Pro Pro Pro Met Glu Arg Thr Gly Gly Ile Gly Asp Ser
            100                 105                 110         
Arg Pro Pro Ser Phe His Pro His Ala Gly Gly Gly Ser Gln Glu Asn
        115                 120                 125             
Leu Asp Asn Asp Thr Glu Thr Asp Ser Leu Val Ser Ala Gln Arg Glu
    130                 135                 140                 
Arg Pro Arg Arg Arg Asp Gly Pro Glu His Ala Thr Arg Leu Asn Gly
145                 150                 155                 160 
Thr Ala Lys Gly Glu Arg Arg Arg Glu Pro Gly Gly Tyr Asp Ser Ser
                165                 170                 175     
Ser Thr Leu Met Ser Ser Glu Leu Glu Thr Thr Ser Phe Phe Asp Ser
            180                 185                 190         
Asp Glu Asp Asp Ser Thr Ser Arg Phe Ser Ser Ser Thr Glu Gln Ser
        195                 200                 205             
Ser Ala Ser Arg Leu Met Arg Arg His Lys Arg Arg Arg Arg Lys Gln
    210                 215                 220                 
Lys Val Ser Arg Ile Glu Arg Ser Ser Ser Phe Ser Ser Ile Thr Asp
225                 230                 235                 240 
Ser Thr Met Ser Leu Asn Ile Ile Thr Val Thr Leu Asn Met Glu Lys
                245                 250                 255     
Tyr Asn Phe Leu Gly Ile Ser Ile Val Gly Gln Ser Asn Glu Arg Gly
            260                 265                 270         
Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly Gly Ala Val Ala
        275                 280                 285             
Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu Gln Val Asn Glu
    290                 295                 300                 
Ile Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val Arg Val Leu Arg
305                 310                 315                 320 
Glu Ile Val His Lys Pro Gly Pro Ile Thr Leu Thr Val Ala Lys Cys
                325                 330                 335     
Trp Asp Pro Ser Pro Arg Gly Cys Phe Thr Leu Pro Arg Ser Glu Pro
            340                 345                 350         
Ile Arg Pro Ile Asp Pro Ala Ala Trp Val Ser His Thr Ala Ala Met
        355                 360                 365             
Thr Gly Thr Phe Pro Ala Tyr Gly Met Ser Pro Ser Leu Ser Thr Ile
    370                 375                 380                 
Thr Ser Thr Ser Ser Ser Ile Thr Ser Ser Ile Pro Asp Thr Glu Arg
385                 390                 395                 400 
Leu Asp Asp Phe His Leu Ser Ile His Ser Asp Met Ala Ala Ile Val
                405                 410                 415     
Lys Ala Met Ala Ser Pro Glu Ser Gly Leu Glu Val Arg Asp Arg Met
            420                 425                 430         
Trp Leu Lys Ile Thr Ile Pro Asn Ala Phe Ile Gly Ser Asp Val Val
        435                 440                 445             
Asp Trp Leu Tyr His Asn Val Glu Gly Phe Thr Asp Arg Arg Glu Ala
    450                 455                 460                 
Arg Lys Tyr Ala Ser Asn Leu Leu Lys Ala Gly Phe Ile Arg His Thr
465                 470                 475                 480 
Val Asn Lys Ile Thr Phe Ser Glu Gln Cys Tyr Tyr Ile Phe Gly Asp
                485                 490                 495     
Leu Cys Gly Asn Met Ala Asn Leu Ser Leu His Asp His Asp Gly Ser
            500                 505                 510         
Ser Gly Ala Ser Asp Gln Asp Thr Leu Ala Pro Leu Pro His Pro Gly
        515                 520                 525             
Ala Ala Pro Trp Pro Met Ala Phe Pro Tyr Gln Tyr Pro Pro Pro Pro
    530                 535                 540                 
His Pro Tyr Asn Pro His Pro Gly Phe Pro Glu Leu Gly Tyr Ser Tyr
545                 550                 555                 560 
Gly Gly Gly Ser Ala Ser Ser Gln His Ser Glu Gly Ser Arg Ser Ser
                565                 570                 575     
Gly Ser Asn Arg Ser Gly Ser Asp Arg Arg Lys Glu Lys Asp Pro Lys
            580                 585                 590         
Ala Gly Asp Ser Lys Ser Gly Gly Ser Gly Ser Glu Ser Asp His Thr
        595                 600                 605             
Thr Arg Ser Ser Leu Arg Gly Pro Arg Glu Arg Ala Pro Ser Glu Arg
    610                 615                 620                 
Ser Gly Pro Ala Ala Ser Glu His Ser His Arg Ser His His Ser Leu
625                 630                 635                 640 
Ala Ser Ser Leu Arg Ser His His Thr His Pro Ser Tyr Gly Pro Pro
                645                 650                 655     
Gly Val Pro Pro Leu Tyr Gly Pro Pro Met Leu Met Met Pro Pro Pro
            660                 665                 670         
Pro Ala Ala Met Gly Pro Pro Gly Ala Pro Pro Gly Arg Asp Leu Ala
        675                 680                 685             
Ser Val Pro Pro Glu Leu Thr Ala Ser Arg Gln Ser Phe Arg Met Ala
    690                 695                 700                 
Met Gly Asn Pro Ser Glu Phe Phe Val Asp Val Met
705                 710                 715     


<210> 6581
<211> 457
<212> PRT
<213> Homo sapiens

<400> 6581
Asn Ser Glu Lys Tyr Asn Phe Leu Gly Ile Ser Ile Val Gly Gln Ser
 1               5                  10                  15      
Asn Glu Arg Gly Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly
            20                  25                  30          
Gly Ala Val Ala Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu
        35                  40                  45              
Gln Val Asn Glu Ile Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val
    50                  55                  60                  
Arg Val Leu Arg Glu Ile Val His Lys Pro Gly Pro Ile Thr Leu Thr
65                  70                  75                  80  
Val Ala Lys Cys Trp Asp Pro Ser Pro Arg Gly Cys Phe Thr Leu Pro
                85                  90                  95      
Arg Ser Glu Pro Ile Arg Pro Ile Asp Pro Ala Ala Trp Val Ser His
            100                 105                 110         
Thr Ala Ala Met Thr Gly Thr Phe Pro Ala Tyr Gly Met Ser Pro Ser
        115                 120                 125             
Leu Ser Thr Ile Thr Ser Thr Ser Ser Ser Ile Thr Ser Ser Ile Pro
    130                 135                 140                 
Asp Thr Glu Arg Leu Asp Asp Phe His Leu Ser Ile His Ser Asp Met
145                 150                 155                 160 
Ala Ala Ile Val Lys Ala Met Ala Ser Pro Glu Ser Gly Leu Glu Val
                165                 170                 175     
Arg Asp Arg Met Trp Leu Lys Ile Thr Ile Pro Asn Ala Phe Ile Gly
            180                 185                 190         
Ser Asp Val Val Asp Trp Leu Tyr His Asn Val Glu Gly Phe Thr Asp
        195                 200                 205             
Arg Arg Glu Ala Arg Lys Tyr Ala Ser Asn Leu Leu Lys Ala Gly Phe
    210                 215                 220                 
Ile Arg His Thr Val Asn Lys Ile Thr Phe Ser Glu Gln Cys Tyr Tyr
225                 230                 235                 240 
Ile Phe Gly Asp Phe Cys Gly Asn Met Ala Asn Leu Ser Leu His Asp
                245                 250                 255     
His Asp Gly Ser Ser Gly Ala Ser Asp Gln Asp Thr Leu Ala Leu Leu
            260                 265                 270         
Pro His Pro Gly Ala Ala Pro Trp Pro Met Ala Phe Pro Tyr Gln Tyr
        275                 280                 285             
Pro Pro Pro Pro His Pro Tyr Asn Pro His Pro Gly Phe Pro Glu Leu
    290                 295                 300                 
Gly Tyr Ser Tyr Gly Gly Gly Ser Ala Ser Ser Gln His Ser Glu Gly
305                 310                 315                 320 
Ser Arg Ser Ser Gly Ser Asn Arg Ser Gly Ser Asp Arg Arg Lys Glu
                325                 330                 335     
Lys Asp Pro Lys Ala Gly Asp Ser Lys Ser Gly Gly Ser Gly Ser Glu
            340                 345                 350         
Ser Asp His Thr Thr Arg Ser Ser Leu Arg Gly Pro Arg Glu Arg Ala
        355                 360                 365             
Pro Ser Glu Arg Ser Gly Pro Ala Ala Ser Glu His Ser His Arg Ser
    370                 375                 380                 
His His Ser Leu Ala Ser Ser Leu Arg Ser His His Thr His Pro Ser
385                 390                 395                 400 
Tyr Gly Pro Pro Gly Val Pro Pro Leu Tyr Gly Pro Pro Met Leu Met
                405                 410                 415     
Met Pro Pro Pro Pro Ala Ala Met Gly Pro Pro Gly Ala Pro Pro Gly
            420                 425                 430         
Arg Asp Pro Gly Leu Ser Ala Pro Gly Thr Asp Arg Gln Gln Thr Val
        435                 440                 445             
Leu Pro His Gly His Gly Lys Pro Gln
    450                 455         


<210> 6582
<211> 2181
<212> PRT
<213> Homo sapiens

<400> 6582
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln
 1               5                  10                  15      
Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu
            20                  25                  30          
Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln
        35                  40                  45              
Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys
    50                  55                  60                  
Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu
65                  70                  75                  80  
Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn
                85                  90                  95      
Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn
            100                 105                 110         
Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe
        115                 120                 125             
Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala
    130                 135                 140                 
Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn
145                 150                 155                 160 
Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr
                165                 170                 175     
Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr
            180                 185                 190         
Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly
        195                 200                 205             
Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly
    210                 215                 220                 
Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg
225                 230                 235                 240 
Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser
                245                 250                 255     
Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu
            260                 265                 270         
His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile
        275                 280                 285             
Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala
    290                 295                 300                 
Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser
305                 310                 315                 320 
Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly
                325                 330                 335     
Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe
            340                 345                 350         
Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp
        355                 360                 365             
Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val
    370                 375                 380                 
Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu
385                 390                 395                 400 
Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala
                405                 410                 415     
Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu
            420                 425                 430         
Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile
        435                 440                 445             
Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr
    450                 455                 460                 
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser
465                 470                 475                 480 
Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp
                485                 490                 495     
Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp
            500                 505                 510         
Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp
        515                 520                 525             
Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr
    530                 535                 540                 
Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile
545                 550                 555                 560 
Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp
                565                 570                 575     
Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val
            580                 585                 590         
Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn
        595                 600                 605             
Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu
    610                 615                 620                 
Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys
625                 630                 635                 640 
Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu
                645                 650                 655     
Cys Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ser Ala Ser
            660                 665                 670         
Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly
        675                 680                 685             
Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys
    690                 695                 700                 
Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln
705                 710                 715                 720 
Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met
                725                 730                 735     
Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe
            740                 745                 750         
Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu
        755                 760                 765             
Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala
    770                 775                 780                 
Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys
785                 790                 795                 800 
Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile
                805                 810                 815     
Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp
            820                 825                 830         
Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu
        835                 840                 845             
Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg
    850                 855                 860                 
Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile
865                 870                 875                 880 
Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg
                885                 890                 895     
Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile
            900                 905                 910         
Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro
        915                 920                 925             
Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr
    930                 935                 940                 
Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr
945                 950                 955                 960 
Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn
                965                 970                 975     
Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile
            980                 985                 990         
Gln Ser Ser Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val
        995                 1000                1005            
Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val
    1010                1015                1020                
Val Gln Cys Val Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Met Ile
1025                1030                1035                1040
Val Thr Thr Leu Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu
                1045                1050                1055    
Phe Lys Gly Lys Phe Tyr Arg Cys Thr Asp Glu Ala Lys Ser Asn Pro
            1060                1065                1070        
Glu Glu Cys Arg Gly Leu Phe Ile Leu Tyr Lys Asp Gly Asp Val Asp
        1075                1080                1085            
Ser Pro Val Val Arg Glu Arg Ile Trp Gln Asn Ser Asp Phe Asn Phe
    1090                1095                1100                
Asp Asn Val Leu Ser Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe
1105                1110                1115                1120
Glu Gly Trp Pro Ala Leu Leu Tyr Lys Ala Ile Asp Ser Asn Gly Glu
                1125                1130                1135    
Asn Ile Gly Pro Ile Tyr Asn His Arg Val Glu Ile Ser Ile Phe Phe
            1140                1145                1150        
Ile Ile Tyr Ile Ile Ile Val Ala Phe Phe Met Met Asn Ile Phe Val
        1155                1160                1165            
Gly Phe Val Ile Val Thr Phe Gln Glu Gln Gly Glu Lys Glu Tyr Lys
    1170                1175                1180                
Asn Cys Glu Leu Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu
1185                1190                1195                1200
Lys Ala Arg Pro Leu Arg Arg Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr
                1205                1210                1215    
Lys Phe Trp Tyr Val Val Asn Ser Ser Pro Phe Glu Tyr Met Met Phe
            1220                1225                1230        
Val Leu Ile Met Leu Asn Thr Leu Cys Leu Ala Met Gln His Tyr Glu
        1235                1240                1245            
Gln Ser Lys Met Phe Asn Asp Ala Met Asp Ile Leu Asn Met Val Phe
    1250                1255                1260                
Thr Gly Val Phe Thr Val Glu Met Val Leu Lys Val Ile Ala Phe Lys
1265                1270                1275                1280
Pro Lys Gly Tyr Phe Ser Asp Ala Trp Asn Thr Phe Asp Ser Leu Ile
                1285                1290                1295    
Val Ile Gly Ser Ile Ile Asp Val Ala Leu Ser Glu Ala Asp Pro Thr
            1300                1305                1310        
Glu Ser Glu Asn Val Pro Val Pro Thr Ala Thr Pro Gly Asn Ser Glu
        1315                1320                1325            
Glu Ser Asn Arg Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met
    1330                1335                1340                
Arg Leu Val Lys Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu
1345                1350                1355                1360
Trp Thr Phe Ile Lys Phe Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu
                1365                1370                1375    
Ile Ala Met Leu Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Met Phe
            1380                1385                1390        
Gly Lys Val Ala Met Arg Asp Asn Asn Gln Ile Asn Arg Asn Asn Asn
        1395                1400                1405            
Phe Gln Thr Phe Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr
    1410                1415                1420                
Gly Glu Ala Trp Gln Glu Ile Met Leu Ala Cys Leu Pro Gly Lys Leu
1425                1430                1435                1440
Cys Asp Pro Glu Ser Asp Tyr Asn Pro Gly Glu Glu His Thr Cys Gly
                1445                1450                1455    
Ser Asn Phe Ala Ile Val Tyr Phe Ile Ser Phe Tyr Met Leu Cys Ala
            1460                1465                1470        
Phe Leu Ile Ile Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Asp
        1475                1480                1485            
Tyr Leu Thr Arg Asp Trp Ser Ile Leu Gly Pro His His Leu Asp Glu
    1490                1495                1500                
Phe Lys Arg Ile Trp Ser Glu Tyr Asp Pro Glu Ala Lys Gly Arg Ile
1505                1510                1515                1520
Lys His Leu Asp Val Val Thr Leu Leu Arg Arg Ile Gln Pro Pro Leu
                1525                1530                1535    
Gly Phe Gly Lys Leu Cys Pro His Arg Val Ala Cys Lys Arg Leu Val
            1540                1545                1550        
Ala Met Asn Met Pro Leu Asn Ser Asp Gly Thr Val Met Phe Asn Ala
        1555                1560                1565            
Thr Leu Phe Ala Leu Val Arg Thr Ala Leu Lys Ile Lys Thr Glu Gly
    1570                1575                1580                
Asn Leu Glu Gln Ala Asn Glu Glu Leu Arg Ala Val Ile Lys Lys Ile
1585                1590                1595                1600
Trp Lys Lys Thr Ser Met Lys Leu Leu Asp Gln Val Val Pro Pro Ala
                1605                1610                1615    
Gly Asp Asp Glu Val Thr Val Gly Lys Phe Tyr Ala Thr Phe Leu Ile
            1620                1625                1630        
Gln Asp Tyr Phe Arg Lys Phe Lys Lys Arg Lys Glu Gln Gly Leu Val
        1635                1640                1645            
Gly Lys Tyr Pro Ala Lys Asn Thr Thr Ile Ala Leu Gln Ala Gly Leu
    1650                1655                1660                
Arg Thr Leu His Asp Ile Gly Pro Glu Ile Arg Arg Ala Ile Ser Cys
1665                1670                1675                1680
Asp Leu Gln Asp Asp Glu Pro Glu Glu Thr Lys Arg Glu Glu Glu Asp
                1685                1690                1695    
Asp Val Phe Lys Arg Asn Gly Ala Leu Leu Gly Asn His Val Asn His
            1700                1705                1710        
Val Asn Ser Asp Arg Arg Asp Ser Leu Gln Gln Thr Asn Thr Thr His
        1715                1720                1725            
Arg Pro Leu His Val Gln Arg Pro Ser Ile Pro Pro Ala Ser Asp Thr
    1730                1735                1740                
Glu Lys Pro Leu Phe Pro Pro Ala Gly Asn Ser Val Cys His Asn His
1745                1750                1755                1760
His Asn His Asn Ser Ile Gly Lys Gln Val Pro Thr Ser Thr Asn Ala
                1765                1770                1775    
Asn Leu Asn Asn Ala Asn Met Ser Lys Ala Ala His Gly Lys Arg Pro
            1780                1785                1790        
Ser Ile Gly Asn Leu Glu His Val Ser Glu Asn Gly His His Ser Ser
        1795                1800                1805            
His Lys His Asp Arg Glu Pro Gln Arg Arg Ser Ser Val Lys Arg Thr
    1810                1815                1820                
Arg Tyr Tyr Glu Thr Tyr Ile Arg Ser Asp Ser Gly Asp Glu Gln Leu
1825                1830                1835                1840
Pro Thr Ile Cys Arg Glu Asp Pro Glu Ile His Gly Tyr Phe Arg Asp
                1845                1850                1855    
Pro His Cys Leu Gly Glu Gln Glu Tyr Phe Ser Ser Glu Glu Cys Tyr
            1860                1865                1870        
Glu Asp Asp Ser Ser Pro Thr Trp Ser Arg Gln Asn Tyr Gly Tyr Tyr
        1875                1880                1885            
Ser Arg Tyr Pro Gly Arg Asn Ile Asp Ser Glu Arg Pro Arg Gly Tyr
    1890                1895                1900                
His His Pro Gln Gly Phe Leu Glu Asp Asp Asp Ser Pro Val Cys Tyr
1905                1910                1915                1920
Asp Ser Arg Arg Ser Pro Arg Arg Arg Leu Leu Pro Pro Thr Pro Ala
                1925                1930                1935    
Ser His Arg Arg Ser Ser Phe Asn Phe Glu Cys Leu Arg Arg Gln Ser
            1940                1945                1950        
Ser Gln Glu Glu Val Pro Ser Ser Pro Ile Phe Pro His Arg Thr Ala
        1955                1960                1965            
Leu Pro Leu His Leu Met Gln Gln Gln Ile Met Ala Val Ala Gly Leu
    1970                1975                1980                
Asp Ser Ser Lys Ala Gln Lys Tyr Ser Pro Ser His Ser Thr Arg Ser
1985                1990                1995                2000
Trp Ala Thr Pro Pro Ala Thr Pro Pro Tyr Arg Asp Trp Thr Pro Cys
                2005                2010                2015    
Tyr Thr Pro Leu Ile Gln Val Glu Gln Ser Glu Ala Leu Asp Gln Val
            2020                2025                2030        
Asn Gly Ser Leu Pro Ser Leu His Arg Ser Ser Trp Tyr Thr Asp Glu
        2035                2040                2045            
Pro Asp Ile Ser Tyr Arg Thr Phe Thr Pro Ala Ser Leu Thr Val Pro
    2050                2055                2060                
Ser Ser Phe Arg Asn Lys Asn Ser Asp Lys Gln Arg Ser Ala Asp Ser
2065                2070                2075                2080
Leu Val Glu Ala Val Leu Ile Ser Glu Gly Leu Gly Arg Tyr Ala Arg
                2085                2090                2095    
Asp Pro Lys Phe Val Ser Ala Thr Lys His Glu Ile Ala Asp Ala Cys
            2100                2105                2110        
Asp Leu Thr Ile Asp Glu Met Glu Ser Ala Ala Ser Thr Leu Leu Asn
        2115                2120                2125            
Gly Asn Val Arg Pro Arg Ala Asn Gly Asp Val Gly Pro Leu Ser His
    2130                2135                2140                
Arg Gln Asp Tyr Glu Leu Gln Asp Phe Gly Pro Gly Tyr Ser Asp Glu
2145                2150                2155                2160
Glu Pro Asp Pro Gly Arg Asp Glu Glu Asp Leu Ala Asp Glu Met Ile
                2165                2170                2175    
Cys Ile Thr Thr Leu
            2180    


<210> 6583
<211> 2161
<212> PRT
<213> Homo sapiens

<400> 6583
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln
 1               5                  10                  15      
Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu
            20                  25                  30          
Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln
        35                  40                  45              
Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys
    50                  55                  60                  
Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu
65                  70                  75                  80  
Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn
                85                  90                  95      
Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn
            100                 105                 110         
Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe
        115                 120                 125             
Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala
    130                 135                 140                 
Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn
145                 150                 155                 160 
Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr
                165                 170                 175     
Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr
            180                 185                 190         
Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly
        195                 200                 205             
Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly
    210                 215                 220                 
Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg
225                 230                 235                 240 
Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser
                245                 250                 255     
Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu
            260                 265                 270         
His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile
        275                 280                 285             
Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala
    290                 295                 300                 
Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser
305                 310                 315                 320 
Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly
                325                 330                 335     
Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe
            340                 345                 350         
Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp
        355                 360                 365             
Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val
    370                 375                 380                 
Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu
385                 390                 395                 400 
Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala
                405                 410                 415     
Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu
            420                 425                 430         
Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile
        435                 440                 445             
Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr
    450                 455                 460                 
Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser
465                 470                 475                 480 
Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile
                485                 490                 495     
Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn
            500                 505                 510         
Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu
        515                 520                 525             
Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His
    530                 535                 540                 
Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys
545                 550                 555                 560 
Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser
                565                 570                 575     
Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys
            580                 585                 590         
Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu
        595                 600                 605             
Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu
    610                 615                 620                 
Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Cys Asn Leu Val
625                 630                 635                 640 
Ala Ser Leu Leu Asn Ser Met Lys Ser Ser Ala Ser Leu Leu Leu Leu
                645                 650                 655     
Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe
            660                 665                 670         
Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe
        675                 680                 685             
Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly
    690                 695                 700                 
Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly
705                 710                 715                 720 
Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe
                725                 730                 735     
Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val
            740                 745                 750         
Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu
        755                 760                 765             
Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu
    770                 775                 780                 
Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp
785                 790                 795                 800 
Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp
                805                 810                 815     
Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu
            820                 825                 830         
Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile
        835                 840                 845             
Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser
    850                 855                 860                 
Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His
865                 870                 875                 880 
Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile
                885                 890                 895     
Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His
            900                 905                 910         
Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala
        915                 920                 925             
Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe
    930                 935                 940                 
Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met
945                 950                 955                 960 
Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala
                965                 970                 975     
Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu
            980                 985                 990         
Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val
        995                 1000                1005            
Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Met Ile Val Thr Thr Leu
    1010                1015                1020                
Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys
1025                1030                1035                1040
Phe Tyr Arg Cys Thr Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg
                1045                1050                1055    
Gly Leu Phe Ile Leu Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val
            1060                1065                1070        
Arg Glu Arg Ile Trp Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu
        1075                1080                1085            
Ser Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro
    1090                1095                1100                
Ala Leu Leu Tyr Lys Ala Ile Asp Ser Asn Gly Glu Asn Ile Gly Pro
1105                1110                1115                1120
Ile Tyr Asn His Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile
                1125                1130                1135    
Ile Ile Val Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile
            1140                1145                1150        
Val Thr Phe Gln Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu
        1155                1160                1165            
Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro
    1170                1175                1180                
Leu Arg Arg Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr
1185                1190                1195                1200
Val Val Asn Ser Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met
                1205                1210                1215    
Leu Asn Thr Leu Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met
            1220                1225                1230        
Phe Asn Asp Ala Met Asp Ile Leu Asn Met Val Phe Thr Gly Val Phe
        1235                1240                1245            
Thr Val Glu Met Val Leu Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr
    1250                1255                1260                
Phe Ser Asp Ala Trp Asn Thr Phe Asp Ser Leu Ile Val Ile Gly Ser
1265                1270                1275                1280
Ile Ile Asp Val Ala Leu Ser Glu Ala Asp Pro Thr Glu Ser Glu Asn
                1285                1290                1295    
Val Pro Val Pro Thr Ala Thr Pro Gly Asn Ser Glu Glu Ser Asn Arg
            1300                1305                1310        
Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys
        1315                1320                1325            
Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile
    1330                1335                1340                
Lys Phe Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu
1345                1350                1355                1360
Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Met Phe Gly Lys Val Ala
                1365                1370                1375    
Met Arg Asp Asn Asn Gln Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe
            1380                1385                1390        
Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp
        1395                1400                1405            
Gln Glu Ile Met Leu Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Glu
    1410                1415                1420                
Ser Asp Tyr Asn Pro Gly Glu Glu His Thr Cys Gly Ser Asn Phe Ala
1425                1430                1435                1440
Ile Val Tyr Phe Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile
                1445                1450                1455    
Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg
            1460                1465                1470        
Asp Trp Ser Ile Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile
        1475                1480                1485            
Trp Ser Glu Tyr Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp
    1490                1495                1500                
Val Val Thr Leu Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys
1505                1510                1515                1520
Leu Cys Pro His Arg Val Ala Cys Lys Arg Leu Val Ala Met Asn Met
                1525                1530                1535    
Pro Leu Asn Ser Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala
            1540                1545                1550        
Leu Val Arg Thr Ala Leu Lys Ile Lys Thr Glu Gly Asn Leu Glu Gln
        1555                1560                1565            
Ala Asn Glu Glu Leu Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Thr
    1570                1575                1580                
Ser Met Lys Leu Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu
1585                1590                1595                1600
Val Thr Val Gly Lys Phe Tyr Ala Thr Phe Leu Ile Gln Asp Tyr Phe
                1605                1610                1615    
Arg Lys Phe Lys Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro
            1620                1625                1630        
Ala Lys Asn Thr Thr Ile Ala Leu Gln Ala Gly Leu Arg Thr Leu His
        1635                1640                1645            
Asp Ile Gly Pro Glu Ile Arg Arg Ala Ile Ser Cys Asp Leu Gln Asp
    1650                1655                1660                
Asp Glu Pro Glu Glu Thr Lys Arg Glu Glu Glu Asp Asp Val Phe Lys
1665                1670                1675                1680
Arg Asn Gly Ala Leu Leu Gly Asn His Val Asn His Val Asn Ser Asp
                1685                1690                1695    
Arg Arg Asp Ser Leu Gln Gln Thr Asn Thr Thr His Arg Pro Leu His
            1700                1705                1710        
Val Gln Arg Pro Ser Ile Pro Pro Ala Ser Asp Thr Glu Lys Pro Leu
        1715                1720                1725            
Phe Pro Pro Ala Gly Asn Ser Val Cys His Asn His His Asn His Asn
    1730                1735                1740                
Ser Ile Gly Lys Gln Val Pro Thr Ser Thr Asn Ala Asn Leu Asn Asn
1745                1750                1755                1760
Ala Asn Met Ser Lys Ala Ala His Gly Lys Arg Pro Ser Ile Gly Asn
                1765                1770                1775    
Leu Glu His Val Ser Glu Asn Gly His His Ser Ser His Lys His Asp
            1780                1785                1790        
Arg Glu Pro Gln Arg Arg Ser Ser Val Lys Arg Thr Arg Tyr Tyr Glu
        1795                1800                1805            
Thr Tyr Ile Arg Ser Asp Ser Gly Asp Glu Gln Leu Pro Thr Ile Cys
    1810                1815                1820                
Arg Glu Asp Pro Glu Ile His Gly Tyr Phe Arg Asp Pro His Cys Leu
1825                1830                1835                1840
Gly Glu Gln Glu Tyr Phe Ser Ser Glu Glu Cys Tyr Glu Asp Asp Ser
                1845                1850                1855    
Ser Pro Thr Trp Ser Arg Gln Asn Tyr Gly Tyr Tyr Ser Arg Tyr Pro
            1860                1865                1870        
Gly Arg Asn Ile Asp Ser Glu Arg Pro Arg Gly Tyr His His Pro Gln
        1875                1880                1885            
Gly Phe Leu Glu Asp Asp Asp Ser Pro Val Cys Tyr Asp Ser Arg Arg
    1890                1895                1900                
Ser Pro Arg Arg Arg Leu Leu Pro Pro Thr Pro Ala Ser His Arg Arg
1905                1910                1915                1920
Ser Ser Phe Asn Phe Glu Cys Leu Arg Arg Gln Ser Ser Gln Glu Glu
                1925                1930                1935    
Val Pro Ser Ser Pro Ile Phe Pro His Arg Thr Ala Leu Pro Leu His
            1940                1945                1950        
Leu Met Gln Gln Gln Ile Met Ala Val Ala Gly Leu Asp Ser Ser Lys
        1955                1960                1965            
Ala Gln Lys Tyr Ser Pro Ser His Ser Thr Arg Ser Trp Ala Thr Pro
    1970                1975                1980                
Pro Ala Thr Pro Pro Tyr Arg Asp Trp Thr Pro Cys Tyr Thr Pro Leu
1985                1990                1995                2000
Ile Gln Val Glu Gln Ser Glu Ala Leu Asp Gln Val Asn Gly Ser Leu
                2005                2010                2015    
Pro Ser Leu His Arg Ser Ser Trp Tyr Thr Asp Glu Pro Asp Ile Ser
            2020                2025                2030        
Tyr Arg Thr Phe Thr Pro Ala Ser Leu Thr Val Pro Ser Ser Phe Arg
        2035                2040                2045            
Asn Lys Asn Ser Asp Lys Gln Arg Ser Ala Asp Ser Leu Val Glu Ala
    2050                2055                2060                
Val Leu Ile Ser Glu Gly Leu Gly Arg Tyr Ala Arg Asp Pro Lys Phe
2065                2070                2075                2080
Val Ser Ala Thr Lys His Glu Ile Ala Asp Ala Cys Asp Leu Thr Ile
                2085                2090                2095    
Asp Glu Met Glu Ser Ala Ala Ser Thr Leu Leu Asn Gly Asn Val Arg
            2100                2105                2110        
Pro Arg Ala Asn Gly Asp Val Gly Pro Leu Ser His Arg Gln Asp Tyr
        2115                2120                2125            
Glu Leu Gln Asp Phe Gly Pro Gly Tyr Ser Asp Glu Glu Pro Asp Pro
    2130                2135                2140                
Gly Arg Asp Glu Glu Asp Leu Ala Asp Glu Met Ile Cys Ile Thr Thr
2145                2150                2155                2160
Leu
    


<210> 6584
<211> 523
<212> PRT
<213> Homo sapiens

<400> 6584
Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro Glu Val Ala Asp
 1               5                  10                  15      
Gly Gly Gly Ala Pro Pro Gln Gly Gly Cys Gly Gly Gly Gly Cys Asp
            20                  25                  30          
Arg Tyr Glu Pro Leu Pro Pro Ser Leu Pro Ala Ala Gly Glu Gln Asp
        35                  40                  45              
Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe Glu
    50                  55                  60                  
Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr Leu Leu Gly Asp
65                  70                  75                  80  
Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe
                85                  90                  95      
Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln
            100                 105                 110         
Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro Ile Asp Ile Phe
        115                 120                 125             
Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu Ala Met Glu Lys
    130                 135                 140                 
Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu Arg Pro Leu Pro
145                 150                 155                 160 
Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro Glu
                165                 170                 175     
Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile
            180                 185                 190         
Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg
        195                 200                 205             
Asp Glu Lys Asp Tyr Pro Ala Ser Thr Ser Gln Asp Ser Phe Glu Ala
    210                 215                 220                 
Ala Gly Asn Ser Thr Ser Gly Ser Arg Ala Gly Ala Ser Ser Phe Ser
225                 230                 235                 240 
Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe
                245                 250                 255     
Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys Ala Thr Phe Ser
            260                 265                 270         
Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe
        275                 280                 285             
Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly Asn Gly Gln Gln
    290                 295                 300                 
Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe
305                 310                 315                 320 
Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly
                325                 330                 335     
Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe
            340                 345                 350         
Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu
        355                 360                 365             
Ala Asp Asp Pro Thr Ser Gly Phe Ser Ser Ile Pro Asp Ala Phe Trp
    370                 375                 380                 
Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met His Pro
385                 390                 395                 400 
Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly
                405                 410                 415     
Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn
            420                 425                 430         
Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln Ser Gln Tyr Met
        435                 440                 445             
His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala Glu Glu Leu Arg
    450                 455                 460                 
Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu Tyr Met Val Ile
465                 470                 475                 480 
Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln Thr Pro Phe Lys
                485                 490                 495     
Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn Asn Pro Asn Ser
            500                 505                 510         
Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val
        515                 520             


<210> 6585
<211> 536
<212> PRT
<213> Homo sapiens

<400> 6585
Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser
 1               5                  10                  15      
Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln
            20                  25                  30          
Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe
        35                  40                  45              
Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser
    50                  55                  60                  
Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu
65                  70                  75                  80  
Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln
                85                  90                  95      
Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln
            100                 105                 110         
Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala
        115                 120                 125             
Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu
    130                 135                 140                 
Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val
145                 150                 155                 160 
Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp
                165                 170                 175     
Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp
            180                 185                 190         
Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln
        195                 200                 205             
Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu
    210                 215                 220                 
Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro
225                 230                 235                 240 
Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu
                245                 250                 255     
Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu
            260                 265                 270         
Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu
        275                 280                 285             
Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly
    290                 295                 300                 
Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu
305                 310                 315                 320 
Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr
                325                 330                 335     
Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr
            340                 345                 350         
Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg
        355                 360                 365             
Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser
    370                 375                 380                 
Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met
385                 390                 395                 400 
Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly
                405                 410                 415     
Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp
            420                 425                 430         
Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp
        435                 440                 445             
Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys
    450                 455                 460                 
Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys
465                 470                 475                 480 
Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val
                485                 490                 495     
Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys
            500                 505                 510         
Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile
        515                 520                 525             
His Thr Tyr Leu Trp His Arg Gln
    530                 535     


<210> 6586
<211> 286
<212> PRT
<213> Homo sapiens

<400> 6586
Met Arg Leu Leu Pro Arg Leu Leu Leu Leu Leu Leu Leu Val Phe Pro
 1               5                  10                  15      
Ala Thr Val Leu Phe Arg Gly Gly Pro Arg Gly Leu Leu Ala Val Ala
            20                  25                  30          
Gln Asp Leu Thr Glu Asp Glu Glu Thr Val Glu Asp Ser Ile Ile Glu
        35                  40                  45              
Asp Glu Asp Asp Glu Ala Glu Val Glu Glu Asp Glu Pro Thr Asp Leu
    50                  55                  60                  
Val Glu Asp Lys Glu Glu Glu Asp Val Ser Gly Glu Pro Glu Ala Ser
65                  70                  75                  80  
Pro Ser Ala Asp Thr Thr Ile Leu Phe Val Lys Gly Glu Asp Phe Pro
                85                  90                  95      
Ala Asn Asn Ile Val Lys Phe Leu Val Gly Phe Thr Asn Lys Gly Thr
            100                 105                 110         
Glu Asp Phe Ile Val Glu Ser Leu Asp Ala Ser Phe Arg Tyr Pro Gln
        115                 120                 125             
Asp Tyr Gln Phe Tyr Ile Gln Asn Phe Thr Ala Leu Pro Leu Asn Thr
    130                 135                 140                 
Val Val Pro Pro Gln Arg Gln Ala Thr Phe Glu Tyr Ser Phe Ile Pro
145                 150                 155                 160 
Ala Glu Pro Met Gly Gly Arg Pro Phe Gly Leu Val Ile Asn Leu Asn
                165                 170                 175     
Tyr Lys Asp Leu Asn Gly Asn Val Phe Gln Asp Ala Val Phe Asn Gln
            180                 185                 190         
Thr Val Thr Val Ile Glu Arg Glu Asp Gly Leu Asp Gly Glu Thr Ile
        195                 200                 205             
Phe Met Tyr Met Phe Leu Ala Gly Leu Gly Leu Leu Val Ile Val Gly
    210                 215                 220                 
Leu His Gln Leu Leu Glu Ser Arg Lys Arg Lys Arg Pro Ile Gln Lys
225                 230                 235                 240 
Val Glu Met Gly Thr Ser Ser Gln Asn Asp Val Asp Met Ser Trp Ile
                245                 250                 255     
Pro Gln Glu Thr Leu Asn Gln Ile Asn Lys Ala Ser Pro Arg Arg Leu
            260                 265                 270         
Pro Arg Lys Arg Ala Gln Lys Arg Ser Val Gly Ser Asp Glu
        275                 280                 285     


<210> 6587
<211> 1366
<212> PRT
<213> Homo sapiens

<400> 6587
Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr
 1               5                  10                  15      
Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys
            20                  25                  30          
Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly
        35                  40                  45              
Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro
    50                  55                  60                  
Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln
65                  70                  75                  80  
Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met
                85                  90                  95      
Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly
            100                 105                 110         
Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro
        115                 120                 125             
Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp
    130                 135                 140                 
Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly
145                 150                 155                 160 
Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe
                165                 170                 175     
Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro
            180                 185                 190         
Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly
        195                 200                 205             
Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg
    210                 215                 220                 
Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val
225                 230                 235                 240 
Gly Pro Val Gly Pro Ala Gly Pro Asn Gly Ser Ala Gly Pro Pro Gly
                245                 250                 255     
Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn
            260                 265                 270         
Ala Gly Pro Thr Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro
        275                 280                 285             
Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly
    290                 295                 300                 
Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala
305                 310                 315                 320 
Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala
                325                 330                 335     
Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly
            340                 345                 350         
Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro
        355                 360                 365             
Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn
    370                 375                 380                 
Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly
385                 390                 395                 400 
Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val
                405                 410                 415     
Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg
            420                 425                 430         
Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly
        435                 440                 445             
Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys
    450                 455                 460                 
Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile
465                 470                 475                 480 
Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly
                485                 490                 495     
Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His
            500                 505                 510         
Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn
        515                 520                 525             
Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly
    530                 535                 540                 
Glu Gln Gly Pro Asp Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro
545                 550                 555                 560 
Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His
                565                 570                 575     
Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly
            580                 585                 590         
Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser
        595                 600                 605             
Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro
    610                 615                 620                 
Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly
625                 630                 635                 640 
Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu
                645                 650                 655     
Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp
            660                 665                 670         
Gly Ala Arg Gly Ala His Gly Ala Val Gly Ala Pro Gly Pro Ala Gly
        675                 680                 685             
Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro
    690                 695                 700                 
Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala
705                 710                 715                 720 
Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly
                725                 730                 735     
Ala Lys Gly Glu Arg Gly Gly Lys Gly Pro Lys Gly Glu Asn Gly Val
            740                 745                 750         
Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn
        755                 760                 765             
Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly
    770                 775                 780                 
Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro
785                 790                 795                 800 
Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu
                805                 810                 815     
Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly
            820                 825                 830         
Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro
        835                 840                 845             
Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln
    850                 855                 860                 
Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly
865                 870                 875                 880 
Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro
                885                 890                 895     
Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val
            900                 905                 910         
Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly
        915                 920                 925             
Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His
    930                 935                 940                 
Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala
945                 950                 955                 960 
Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly
                965                 970                 975     
Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala
            980                 985                 990         
Val Gly Pro Arg Gly Pro Ser Gly Pro Gln Gly Ile Arg Gly Asp Lys
        995                 1000                1005            
Gly Glu Pro Gly Glu Lys Gly Pro Arg Gly Leu Pro Gly Phe Lys Gly
    1010                1015                1020                
His Asn Gly Leu Gln Gly Leu Pro Gly Ile Ala Gly His His Gly Asp
1025                1030                1035                1040
Gln Gly Ala Pro Gly Ser Val Gly Pro Ala Gly Pro Arg Gly Pro Ala
                1045                1050                1055    
Gly Pro Ser Gly Pro Ala Gly Lys Asp Gly Arg Thr Gly His Pro Gly
            1060                1065                1070        
Thr Val Gly Pro Ala Gly Ile Arg Gly Pro Gln Gly His Gln Gly Pro
        1075                1080                1085            
Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Ser
    1090                1095                1100                
Gly Gly Gly Tyr Asp Phe Gly Tyr Asp Gly Asp Phe Tyr Arg Ala Asp
1105                1110                1115                1120
Gln Pro Arg Ser Ala Pro Ser Leu Arg Pro Lys Asp Tyr Glu Val Asp
                1125                1130                1135    
Ala Thr Leu Lys Ser Leu Asn Asn Gln Ile Glu Thr Leu Leu Thr Pro
            1140                1145                1150        
Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Arg Leu
        1155                1160                1165            
Ser His Pro Glu Trp Ser Ser Gly Tyr Tyr Trp Ile Asp Pro Asn Gln
    1170                1175                1180                
Gly Cys Thr Met Glu Ala Ile Lys Val Tyr Cys Asp Phe Pro Thr Gly
1185                1190                1195                1200
Glu Thr Cys Ile Arg Ala Gln Pro Glu Asn Ile Pro Ala Lys Asn Trp
                1205                1210                1215    
Tyr Arg Ser Ser Lys Asp Lys Lys His Val Trp Leu Gly Glu Thr Ile
            1220                1225                1230        
Asn Ala Gly Ser Gln Phe Glu Tyr Asn Val Glu Gly Val Thr Ser Lys
        1235                1240                1245            
Glu Met Ala Thr Gln Leu Ala Phe Met Arg Leu Leu Ala Asn Tyr Ala
    1250                1255                1260                
Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met Asp
1265                1270                1275                1280
Glu Glu Thr Gly Asn Leu Lys Lys Ala Val Ile Leu Gln Gly Ser Asn
                1285                1290                1295    
Asp Val Glu Leu Val Ala Glu Gly Asn Ser Arg Phe Thr Tyr Thr Val
            1300                1305                1310        
Leu Val Asp Gly Cys Ser Lys Lys Thr Asn Glu Trp Gly Lys Thr Ile
        1315                1320                1325            
Ile Glu Tyr Lys Thr Asn Lys Pro Ser Arg Leu Pro Phe Leu Asp Ile
    1330                1335                1340                
Ala Pro Leu Asp Ile Gly Gly Ala Asp His Glu Phe Phe Val Asp Ile
1345                1350                1355                1360
Gly Pro Val Cys Phe Lys
                1365    


<210> 6588
<211> 1239
<212> PRT
<213> Homo sapiens

<400> 6588
Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr
 1               5                  10                  15      
Leu Cys Leu Ala Thr Cys Gln Cys Lys Cys Leu Gln Leu Val Trp Gly
            20                  25                  30          
Arg Leu Gly Arg Glu Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Glu
        35                  40                  45              
Asp Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro
    50                  55                  60                  
Gly Leu Gly Gly Asn Phe Ala Ala Gln Tyr Asp Gly Lys Gly Val Gly
65                  70                  75                  80  
Leu Gly Pro Gly Pro Met Gly Leu Met Gly Pro Arg Gly Pro Pro Gly
                85                  90                  95      
Ala Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Ala Gly Glu
            100                 105                 110         
Pro Gly Glu Pro Gly Gln Thr Gly Pro Ala Gly Ala Arg Gly Pro Ala
        115                 120                 125             
Gly Pro Pro Gly Lys Ala Gly Glu Asp Gly His Pro Gly Lys Pro Gly
    130                 135                 140                 
Arg Pro Gly Glu Arg Gly Val Val Gly Pro Gln Gly Ala Arg Gly Phe
145                 150                 155                 160 
Pro Gly Thr Pro Gly Leu Pro Gly Phe Lys Gly Ile Arg Gly His Asn
                165                 170                 175     
Gly Leu Asp Gly Leu Lys Gly Gln Pro Gly Ala Pro Gly Val Lys Gly
            180                 185                 190         
Glu Pro Gly Ala Pro Gly Glu Asn Gly Thr Pro Gly Gln Thr Gly Glu
        195                 200                 205             
Ile Gly Ala Val Gly Asn Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg
    210                 215                 220                 
Gly Glu Val Gly Leu Pro Gly Leu Ser Gly Pro Val Gly Pro Pro Gly
225                 230                 235                 240 
Asn Pro Gly Ala Asn Gly Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu
                245                 250                 255     
Pro Gly Val Ala Gly Ala Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro
            260                 265                 270         
Gly Pro Val Gly Ala Ala Gly Ala Thr Gly Ala Arg Gly Leu Val Gly
        275                 280                 285             
Glu Pro Gly Pro Ala Gly Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu
    290                 295                 300                 
Pro Gly Ser Ala Gly Pro Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu
305                 310                 315                 320 
Gly Lys Arg Gly Pro Asn Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly
                325                 330                 335     
Pro Pro Gly Leu Arg Gly Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala
            340                 345                 350         
Asp Gly Arg Ala Gly Val Met Gly Pro Pro Gly Ser Arg Gly Ala Ser
        355                 360                 365             
Gly Pro Ala Gly Val Arg Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly
    370                 375                 380                 
Glu Pro Gly Leu Met Gly Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn
385                 390                 395                 400 
Ile Gly Pro Ala Gly Lys Glu Gly Pro Val Gly Leu Pro Gly Ile Asp
                405                 410                 415     
Gly Arg Pro Gly Pro Ile Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly
            420                 425                 430         
Asn Ile Gly Phe Pro Gly Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys
        435                 440                 445             
Asn Gly Asp Lys Gly His Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro
    450                 455                 460                 
Gly Pro Asp Gly Asn Asn Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly
465                 470                 475                 480 
Val Gln Gly Gly Lys Gly Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe
                485                 490                 495     
Gln Gly Leu Pro Gly Pro Ser Gly Pro Ala Gly Glu Val Gly Lys Pro
            500                 505                 510         
Gly Glu Arg Gly Glu Arg Gly Pro Pro Gly Glu Ser Gly Ala Ala Gly
        515                 520                 525             
Pro Thr Gly Pro Ile Gly Ser Arg Gly Pro Ser Gly Pro Pro Gly Pro
    530                 535                 540                 
Asp Gly Asn Lys Gly Glu Pro Gly Val Val Gly Ala Val Gly Thr Ala
545                 550                 555                 560 
Gly Pro Ser Gly Pro Ser Gly Leu Pro Gly Glu Arg Gly Ala Ala Gly
                565                 570                 575     
Ile Pro Gly Gly Lys Gly Glu Lys Gly Glu Pro Gly Leu Arg Gly Glu
            580                 585                 590         
Ile Gly Asn Pro Gly Arg Asp Gly Ala Arg Gly Glu Ala Gly Ala Ala
        595                 600                 605             
Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly
    610                 615                 620                 
Glu Val Gly Pro Ala Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala
625                 630                 635                 640 
Ala Gly Gln Pro Gly Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys
                645                 650                 655     
Gly Glu Asn Gly Val Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly
            660                 665                 670         
Pro Ala Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys
        675                 680                 685             
Glu Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr
    690                 695                 700                 
Gly Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly
705                 710                 715                 720 
Pro Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro
                725                 730                 735     
Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg
            740                 745                 750         
Gly Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly
        755                 760                 765             
Pro Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala
    770                 775                 780                 
Val Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp
785                 790                 795                 800 
Gly Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly
                805                 810                 815     
His Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala
            820                 825                 830         
Ala Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His
        835                 840                 845             
Gly Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly
    850                 855                 860                 
Ala Val Gly Pro Arg Gly Pro Ser Gly Pro Gln Gly Ile Arg Gly Asp
865                 870                 875                 880 
Lys Gly Glu Pro Gly Glu Lys Gly Pro Arg Gly Leu Pro Gly Leu Lys
                885                 890                 895     
Gly His Asn Gly Leu Gln Gly Leu Pro Gly Ile Ala Gly His His Gly
            900                 905                 910         
Asp Gln Gly Ala Pro Gly Ser Val Gly Pro Ala Gly Pro Arg Gly Pro
        915                 920                 925             
Ala Gly Pro Ser Gly Pro Ala Gly Lys Asp Gly Arg Thr Gly His Pro
    930                 935                 940                 
Gly Thr Val Gly Pro Ala Gly Ile Arg Gly Pro Gln Gly His Gln Gly
945                 950                 955                 960 
Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val
                965                 970                 975     
Ser Gly Gly Gly Tyr Asp Phe Gly Tyr Asp Gly Asp Phe Tyr Arg Ala
            980                 985                 990         
Asp Gln Pro Arg Ser Ala Pro Ser Leu Arg Pro Lys Asp Tyr Glu Val
        995                 1000                1005            
Asp Ala Thr Leu Lys Ser Leu Asn Asn Gln Ile Glu Thr Leu Leu Thr
    1010                1015                1020                
Pro Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Arg
1025                1030                1035                1040
Leu Ser His Pro Glu Trp Ser Ser Gly Tyr Tyr Trp Ile Asp Pro Asn
                1045                1050                1055    
Gln Gly Cys Thr Met Asp Ala Ile Lys Val Tyr Cys Asp Phe Ser Thr
            1060                1065                1070        
Gly Glu Thr Cys Ile Arg Ala Gln Pro Glu Asn Ile Pro Ala Lys Asn
        1075                1080                1085            
Trp Tyr Arg Ser Ser Lys Asp Lys Lys His Val Trp Leu Gly Glu Thr
    1090                1095                1100                
Ile Asn Ala Gly Ser Gln Phe Glu Tyr Asn Val Glu Gly Val Thr Ser
1105                1110                1115                1120
Lys Glu Met Ala Thr Gln Leu Ala Phe Met Arg Leu Leu Ala Asn Tyr
                1125                1130                1135    
Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met
            1140                1145                1150        
Asp Glu Glu Thr Gly Asn Leu Lys Lys Ala Val Ile Leu Gln Gly Ser
        1155                1160                1165            
Asn Asp Val Glu Leu Val Ala Glu Gly Asn Ser Arg Phe Thr Tyr Thr
    1170                1175                1180                
Val Leu Val Asp Gly Cys Ser Lys Lys Thr Asn Glu Trp Gly Lys Thr
1185                1190                1195                1200
Ile Ile Glu Tyr Lys Thr Asn Lys Pro Ser Arg Leu Pro Phe Leu Asp
                1205                1210                1215    
Ile Ala Pro Leu Asp Ile Gly Gly Ala Asp Gln Glu Phe Phe Val Asp
            1220                1225                1230        
Ile Gly Pro Val Cys Phe Lys
        1235                


<210> 6589
<211> 1366
<212> PRT
<213> Homo sapiens

<400> 6589
Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr
 1               5                  10                  15      
Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys
            20                  25                  30          
Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly
        35                  40                  45              
Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro
    50                  55                  60                  
Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln
65                  70                  75                  80  
Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met
                85                  90                  95      
Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly
            100                 105                 110         
Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro
        115                 120                 125             
Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp
    130                 135                 140                 
Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly
145                 150                 155                 160 
Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe
                165                 170                 175     
Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro
            180                 185                 190         
Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly
        195                 200                 205             
Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg
    210                 215                 220                 
Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val
225                 230                 235                 240 
Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly
                245                 250                 255     
Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn
            260                 265                 270         
Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro
        275                 280                 285             
Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly
    290                 295                 300                 
Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala
305                 310                 315                 320 
Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala
                325                 330                 335     
Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly
            340                 345                 350         
Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro
        355                 360                 365             
Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn
    370                 375                 380                 
Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly
385                 390                 395                 400 
Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val
                405                 410                 415     
Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg
            420                 425                 430         
Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly
        435                 440                 445             
Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys
    450                 455                 460                 
Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile
465                 470                 475                 480 
Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly
                485                 490                 495     
Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His
            500                 505                 510         
Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn
        515                 520                 525             
Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly
    530                 535                 540                 
Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro
545                 550                 555                 560 
Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His
                565                 570                 575     
Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly
            580                 585                 590         
Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser
        595                 600                 605             
Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro
    610                 615                 620                 
Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly
625                 630                 635                 640 
Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu
                645                 650                 655     
Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp
            660                 665                 670         
Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly
        675                 680                 685             
Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro
    690                 695                 700                 
Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala
705                 710                 715                 720 
Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly
                725                 730                 735     
Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val
            740                 745                 750         
Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn
        755                 760                 765             
Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly
    770                 775                 780                 
Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro
785                 790                 795                 800 
Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu
                805                 810                 815     
Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly
            820                 825                 830         
Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro
        835                 840                 845             
Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln
    850                 855                 860                 
Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly
865                 870                 875                 880 
Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro
                885                 890                 895     
Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val
            900                 905                 910         
Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly
        915                 920                 925             
Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His
    930                 935                 940                 
Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala
945                 950                 955                 960 
Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly
                965                 970                 975     
Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala
            980                 985                 990         
Val Gly Pro Arg Gly Pro Ser Gly Pro Gln Gly Ile Arg Gly Asp Lys
        995                 1000                1005            
Gly Glu Pro Gly Glu Lys Gly Pro Arg Gly Leu Pro Gly Leu Lys Gly
    1010                1015                1020                
His Asn Gly Leu Gln Gly Leu Pro Gly Ile Ala Gly His His Gly Asp
1025                1030                1035                1040
Gln Gly Ala Pro Gly Ser Val Gly Pro Ala Gly Pro Arg Gly Pro Ala
                1045                1050                1055    
Gly Pro Ser Gly Pro Ala Gly Lys Asp Gly Arg Thr Gly His Pro Gly
            1060                1065                1070        
Thr Val Gly Pro Ala Gly Ile Arg Gly Pro Gln Gly His Gln Gly Pro
        1075                1080                1085            
Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Ser
    1090                1095                1100                
Gly Gly Gly Tyr Asp Phe Gly Tyr Asp Gly Asp Phe Tyr Arg Ala Asp
1105                1110                1115                1120
Gln Pro Arg Ser Ala Pro Ser Leu Arg Pro Lys Asp Tyr Glu Val Asp
                1125                1130                1135    
Ala Thr Leu Lys Ser Leu Asn Asn Gln Ile Glu Thr Leu Leu Thr Pro
            1140                1145                1150        
Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Arg Leu
        1155                1160                1165            
Ser His Pro Glu Trp Ser Ser Gly Tyr Tyr Trp Ile Asp Pro Asn Gln
    1170                1175                1180                
Gly Cys Thr Met Asp Ala Ile Lys Val Tyr Cys Asp Phe Ser Thr Gly
1185                1190                1195                1200
Glu Thr Cys Ile Arg Ala Gln Pro Glu Asn Ile Pro Ala Lys Asn Trp
                1205                1210                1215    
Tyr Arg Ser Ser Lys Asp Lys Lys His Val Trp Leu Gly Glu Thr Ile
            1220                1225                1230        
Asn Ala Gly Ser Gln Phe Glu Tyr Asn Val Glu Gly Val Thr Ser Lys
        1235                1240                1245            
Glu Met Ala Thr Gln Leu Ala Phe Met Arg Leu Leu Ala Asn Tyr Ala
    1250                1255                1260                
Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met Asp
1265                1270                1275                1280
Glu Glu Thr Gly Asn Leu Lys Lys Ala Val Ile Leu Gln Gly Ser Asn
                1285                1290                1295    
Asp Val Glu Leu Val Ala Glu Gly Asn Ser Arg Phe Thr Tyr Thr Val
            1300                1305                1310        
Leu Val Asp Gly Cys Ser Lys Lys Thr Asn Glu Trp Gly Lys Thr Ile
        1315                1320                1325            
Ile Glu Tyr Lys Thr Asn Lys Pro Ser Arg Leu Pro Phe Leu Asp Ile
    1330                1335                1340                
Ala Pro Leu Asp Ile Gly Gly Ala Asp Gln Glu Phe Phe Val Asp Ile
1345                1350                1355                1360
Gly Pro Val Cys Phe Lys
                1365    


<210> 6590
<211> 807
<212> PRT
<213> Homo sapiens

<400> 6590
Met Arg Leu Ser Pro Ala Pro Leu Lys Leu Ser Arg Thr Pro Ala Leu
 1               5                  10                  15      
Leu Ala Leu Ala Leu Pro Leu Ala Ala Ala Leu Ala Phe Ser Asp Glu
            20                  25                  30          
Thr Leu Asp Lys Val Pro Lys Ser Glu Gly Tyr Cys Ser Arg Ile Leu
        35                  40                  45              
Arg Ala Gln Gly Thr Arg Arg Glu Gly Tyr Thr Glu Phe Ser Leu Arg
    50                  55                  60                  
Val Glu Gly Asp Pro Asp Phe Tyr Lys Pro Gly Thr Ser Tyr Arg Val
65                  70                  75                  80  
Thr Leu Ser Ala Ala Pro Pro Ser Tyr Phe Arg Gly Phe Thr Leu Ile
                85                  90                  95      
Ala Leu Arg Glu Asn Arg Glu Gly Asp Lys Glu Glu Asp His Ala Gly
            100                 105                 110         
Thr Phe Gln Ile Ile Asp Glu Glu Glu Thr Gln Phe Met Ser Asn Cys
        115                 120                 125             
Pro Val Ala Val Thr Glu Ser Thr Pro Arg Arg Arg Thr Arg Ile Gln
    130                 135                 140                 
Val Phe Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Ile Leu Lys
145                 150                 155                 160 
Ala Ser Ile Val Gln Lys Arg Ile Ile Tyr Phe Gln Asp Glu Gly Ser
                165                 170                 175     
Leu Thr Lys Lys Leu Cys Glu Gln Asp Ser Thr Phe Asp Gly Val Thr
            180                 185                 190         
Asp Lys Pro Ile Leu Asp Cys Cys Ala Cys Gly Thr Ala Lys Tyr Arg
        195                 200                 205             
Leu Thr Phe Tyr Gly Asn Trp Ser Glu Lys Thr His Pro Lys Asp Tyr
    210                 215                 220                 
Pro Arg Arg Ala Asn His Trp Ser Ala Ile Ile Gly Gly Ser His Ser
225                 230                 235                 240 
Lys Asn Tyr Val Leu Trp Glu Tyr Gly Gly Tyr Ala Ser Glu Gly Val
                245                 250                 255     
Lys Gln Val Ala Glu Leu Gly Ser Pro Val Lys Met Glu Glu Glu Ile
            260                 265                 270         
Arg Gln Gln Ser Asp Glu Val Leu Thr Val Ile Lys Ala Lys Ala Gln
        275                 280                 285             
Trp Pro Ala Trp Gln Pro Leu Asn Val Arg Ala Ala Pro Ser Ala Glu
    290                 295                 300                 
Phe Ser Val Asp Arg Thr Arg His Leu Met Ser Phe Leu Thr Met Met
305                 310                 315                 320 
Gly Pro Ser Pro Asp Trp Asn Val Gly Leu Ser Ala Glu Asp Leu Cys
                325                 330                 335     
Thr Lys Glu Cys Gly Trp Val Gln Lys Val Val Gln Asp Leu Ile Pro
            340                 345                 350         
Trp Asp Ala Gly Thr Asp Ser Gly Val Thr Tyr Glu Ser Pro Asn Lys
        355                 360                 365             
Pro Thr Ile Pro Gln Glu Lys Ile Arg Pro Leu Thr Ser Leu Asp His
    370                 375                 380                 
Pro Gln Ser Pro Phe Tyr Asp Pro Glu Gly Gly Ser Ile Thr Gln Val
385                 390                 395                 400 
Ala Arg Val Val Ile Glu Arg Ile Ala Arg Lys Gly Glu Gln Cys Asn
                405                 410                 415     
Ile Val Pro Asp Asn Val Asp Asp Ile Val Ala Asp Leu Ala Pro Glu
            420                 425                 430         
Glu Lys Asp Glu Asp Asp Thr Pro Glu Thr Cys Ile Tyr Ser Asn Trp
        435                 440                 445             
Ser Pro Trp Ser Ala Cys Ser Ser Ser Thr Cys Asp Lys Gly Lys Arg
    450                 455                 460                 
Met Arg Gln Arg Met Leu Lys Ala Gln Leu Asp Leu Ser Val Pro Cys
465                 470                 475                 480 
Pro Asp Thr Gln Asp Phe Gln Pro Cys Met Gly Pro Gly Cys Ser Asp
                485                 490                 495     
Glu Asp Gly Pro Thr Cys Thr Met Ser Glu Trp Ile Thr Trp Ser Pro
            500                 505                 510         
Cys Ser Ile Ser Cys Gly Met Gly Met Arg Ser Arg Glu Arg Tyr Val
        515                 520                 525             
Lys Gln Phe Pro Glu Asp Gly Ser Val Cys Thr Leu Pro Thr Glu Glu
    530                 535                 540                 
Thr Glu Lys Cys Thr Val Asn Glu Glu Cys Ser Pro Ser Ser Cys Leu
545                 550                 555                 560 
Met Thr Glu Trp Gly Glu Trp Asp Glu Tyr Ser Ala Thr Cys Gly Met
                565                 570                 575     
Gly Met Lys Lys Arg His Arg Met Ile Lys Met Asn Pro Ala Asp Gly
            580                 585                 590         
Ser Met Cys Lys Ala Glu Thr Ser Gln Ala Glu Lys Arg Met Met Pro
        595                 600                 605             
Glu Cys His Thr Ile Pro Cys Leu Leu Ser Pro Trp Ser Glu Trp Ser
    610                 615                 620                 
Asp Cys Ser Val Thr Cys Gly Lys Gly Met Arg Thr Arg Gln Arg Met
625                 630                 635                 640 
Leu Lys Ser Leu Ala Glu Leu Gly Asp Cys Asn Glu Asp Leu Glu Gln
                645                 650                 655     
Val Glu Lys Cys Met Leu Pro Glu Cys Pro Ile Asp Cys Glu Leu Thr
            660                 665                 670         
Glu Trp Ser Gln Trp Ser Glu Cys Asn Lys Ser Cys Gly Lys Gly His
        675                 680                 685             
Val Ile Arg Thr Arg Met Ile Gln Met Glu Pro Gln Phe Gly Gly Ala
    690                 695                 700                 
Pro Cys Pro Glu Thr Val Gln Arg Lys Lys Cys Arg Ile Arg Lys Cys
705                 710                 715                 720 
Leu Arg Asn Pro Ser Ile Gln Lys Leu Arg Trp Arg Glu Ala Arg Glu
                725                 730                 735     
Ser Arg Arg Ser Glu Gln Leu Lys Glu Glu Ser Glu Gly Glu Gln Phe
            740                 745                 750         
Pro Gly Cys Arg Met Arg Pro Trp Thr Ala Trp Ser Glu Cys Thr Lys
        755                 760                 765             
Leu Cys Gly Gly Gly Ile Gln Glu Arg Tyr Met Thr Val Lys Lys Arg
    770                 775                 780                 
Phe Lys Ser Ser Gln Phe Thr Ser Cys Lys Asp Lys Lys Glu Ile Arg
785                 790                 795                 800 
Ala Cys Asn Val His Pro Cys
                805         


<210> 6591
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 6591
Met Ala Arg Thr Arg Asp Arg Val Arg Leu Leu Leu Leu Leu Ile Cys
 1               5                  10                  15      
Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg Asn
            20                  25                  30          
Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys Arg
        35                  40                  45              
Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu Ser
    50                  55                  60                  
Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu Arg
65                  70                  75                  80  
Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu Pro
                85                  90                  95      
Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn Val
            100                 105                 110         
Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr Gly
        115                 120                 125             
Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu Leu
    130                 135                 140                 
Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr Gln
145                 150                 155                 160 
Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr Leu
                165                 170                 175     
Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu Asn
            180                 185                 190         
Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro Pro
        195                 200                 205             
Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser Val
    210                 215                 220                 
Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu Ala
225                 230                 235                 240 
Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala Gln
                245                 250                 255     
Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val Glu
            260                 265                 270         
Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val Glu
        275                 280                 285             
Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp Asn
    290                 295                 300                 
Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr Phe
305                 310                 315                 320 
His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu Ile
                325                 330                 335     
Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val Ile
            340                 345                 350         
Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr Lys
        355                 360                 365             
Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu Gly
    370                 375                 380                 
Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser Met
385                 390                 395                 400 
Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe Asp
                405                 410                 415     
Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu Asp
            420                 425                 430         
Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys Leu
        435                 440                 445             
Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr Tyr
    450                 455                 460                 
Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr Ile
465                 470                 475                 480 
Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys Pro
                485                 490                 495     
Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr Val
            500                 505                 510         
Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro Phe
        515                 520                 525             
Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp Lys
    530                 535                 540                 
Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu Lys
545                 550                 555                 560 
Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln Gly
                565                 570                 575     
Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu Val
            580                 585                 590         
Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val Gly
        595                 600                 605             
Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu Leu
    610                 615                 620                 
Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly Ala
625                 630                 635                 640 
Lys Ala Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro Trp
                645                 650                 655     
Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe Leu
            660                 665                 670         
Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly Gly
        675                 680                 685             
Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile Val
    690                 695                 700                 
Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu His
705                 710                 715                 720 
Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr Gly
                725                 730                 735     
Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly Ala
            740                 745                 750         
Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn Glu
        755                 760                 765             
Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr Glu
    770                 775                 780                 
Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser Gln
785                 790                 795                 800 
Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe Ile
                805                 810                 815     
Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys Phe
            820                 825                 830         
Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn Lys
        835                 840                 845             
Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn Thr
    850                 855                 860                 
Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn Thr
865                 870                 875                 880 
Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu Ala
                885                 890                 895     
Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val Ser
            900                 905                 910         
Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met Ala
        915                 920                 925             
Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser Thr
    930                 935                 940                 
Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser Leu
945                 950                 955                 960 
Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp Gln
                965                 970                 975     
Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile Gln
            980                 985                 990         
Pro His Gly Gly Gly Ser Asn Pro Leu Glu Gly Thr Gln His Leu Gln
        995                 1000                1005            
Asp Val Pro Tyr Val Met Val Arg Glu Arg Glu Ser Phe Leu Ala Pro
    1010                1015                1020                
Ser Ser Gly Val Gln Pro Thr Leu Ala Met Pro Asn Ile Ala Val Gly
1025                1030                1035                1040
Gln Asn Val Thr Val Thr Glu Arg Val Leu Ala Pro Ala Ser Thr Leu
                1045                1050                1055    
Gln Ser Ser Tyr Gln Ile Pro Thr Glu Asn Ser Met Thr Ala Arg Asn
            1060                1065                1070        
Thr Thr Val Ser Gly Ala Gly Val Pro Gly Pro Leu Pro Asp Phe Gly
        1075                1080                1085            
Leu Glu Glu Ser Gly His Ser Asn Ser Thr Ile Thr Thr Ser Ser Thr
    1090                1095                1100                
Arg Val Thr Lys His Ser Thr Val Gln His Ser Tyr Ser
1105                1110                1115        


<210> 6592
<211> 1890
<212> PRT
<213> Homo sapiens

<400> 6592
Arg Val Asp Pro Ile Gly Pro Gly Leu Asp Arg Glu Arg Leu Tyr Trp
 1               5                  10                  15      
Glu Leu Ser Gln Leu Thr Asn Ser Ile Thr Glu Leu Gly Pro Tyr Thr
            20                  25                  30          
Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Asn Pro Trp Ser Ser
        35                  40                  45              
Val Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr Val His Leu Ala Thr
    50                  55                  60                  
Ser Gly Thr Pro Ser Ser Leu Pro Gly His Thr Ala Pro Val Pro Leu
65                  70                  75                  80  
Leu Ile Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu His Tyr Glu
                85                  90                  95      
Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg
            100                 105                 110         
Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Ser Thr Ser Val Gly
        115                 120                 125             
Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys His
    130                 135                 140                 
Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr Leu Arg Leu Asp Pro
145                 150                 155                 160 
Thr Gly Pro Gly Leu Asp Arg Glu Arg Leu Tyr Trp Glu Leu Ser Gln
                165                 170                 175     
Leu Thr Asn Ser Val Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp
            180                 185                 190         
Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr
        195                 200                 205             
Ser Ile Pro Gly Thr Ser Ala Val His Leu Glu Thr Ser Gly Thr Pro
    210                 215                 220                 
Ala Ser Leu Pro Gly His Thr Ala Pro Gly Pro Leu Leu Val Pro Phe
225                 230                 235                 240 
Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met Arg
                245                 250                 255     
His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly
            260                 265                 270         
Leu Leu Lys Pro Leu Phe Lys Ser Thr Ser Val Gly Pro Leu Tyr Ser
        275                 280                 285             
Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Arg Gly Ala Ala Thr
    290                 295                 300                 
Gly Val Asp Thr Ile Cys Thr His Arg Leu Asp Pro Leu Asn Pro Gly
305                 310                 315                 320 
Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Lys Leu Thr Arg Gly
                325                 330                 335     
Ile Ile Glu Leu Gly Pro Tyr Leu Leu Asp Arg Gly Ser Leu Tyr Val
            340                 345                 350         
Asn Gly Phe Thr His Arg Asn Phe Val Pro Ile Thr Ser Thr Pro Gly
        355                 360                 365             
Thr Ser Thr Val His Leu Gly Thr Ser Glu Thr Pro Ser Ser Leu Pro
    370                 375                 380                 
Arg Pro Ile Val Pro Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe
385                 390                 395                 400 
Thr Ile Thr Asn Leu Gln Tyr Glu Glu Ala Met Arg His Pro Gly Ser
                405                 410                 415     
Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro
            420                 425                 430         
Leu Phe Lys Asn Thr Ser Ile Gly Pro Leu Tyr Ser Ser Cys Arg Leu
        435                 440                 445             
Thr Leu Leu Arg Pro Glu Lys Asp Lys Ala Ala Thr Arg Val Asp Ala
    450                 455                 460                 
Ile Cys Thr His His Pro Asp Pro Gln Ser Pro Gly Leu Asn Arg Glu
465                 470                 475                 480 
Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Gly Ile Thr Glu Leu
                485                 490                 495     
Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val Asp Gly Phe Thr
            500                 505                 510         
His Trp Ser Pro Ile Pro Thr Thr Ser Thr Pro Gly Thr Ser Ile Val
        515                 520                 525             
Asn Leu Gly Thr Ser Gly Ile Pro Pro Ser Leu Pro Glu Thr Thr Ala
    530                 535                 540                 
Thr Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn
545                 550                 555                 560 
Leu Gln Tyr Glu Glu Asn Met Gly His Pro Gly Ser Arg Lys Phe Asn
                565                 570                 575     
Ile Thr Glu Ser Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Ser
            580                 585                 590         
Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg
        595                 600                 605             
Pro Glu Lys Asp Gly Val Ala Thr Arg Val Asp Ala Ile Cys Thr His
    610                 615                 620                 
Arg Pro Asp Pro Lys Ile Pro Gly Leu Asp Arg Gln Gln Leu Tyr Trp
625                 630                 635                 640 
Glu Leu Ser Gln Leu Thr His Ser Ile Thr Glu Leu Gly Pro Tyr Thr
                645                 650                 655     
Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr Gln Arg Ser Ser
            660                 665                 670         
Val Pro Thr Thr Ser Thr Pro Gly Thr Phe Thr Val Gln Pro Glu Thr
        675                 680                 685             
Ser Glu Thr Pro Ser Ser Leu Pro Gly Pro Thr Ala Thr Gly Pro Val
    690                 695                 700                 
Leu Leu Pro Phe Thr Leu Asn Phe Thr Ile Ile Asn Leu Gln Tyr Glu
705                 710                 715                 720 
Glu Asp Met His Arg Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg
                725                 730                 735     
Val Leu Gln Gly Leu Leu Met Pro Leu Phe Lys Asn Thr Ser Val Ser
            740                 745                 750         
Ser Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp
        755                 760                 765             
Gly Ala Ala Thr Arg Val Asp Ala Val Cys Thr His Arg Pro Asp Pro
    770                 775                 780                 
Lys Ser Pro Gly Leu Asp Arg Glu Arg Leu Tyr Trp Lys Leu Ser Gln
785                 790                 795                 800 
Leu Thr His Gly Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg His
                805                 810                 815     
Ser Leu Tyr Val Asn Gly Phe Thr His Gln Ser Ser Met Thr Thr Thr
            820                 825                 830         
Arg Thr Pro Asp Thr Ser Thr Met His Leu Ala Thr Ser Arg Thr Pro
        835                 840                 845             
Ala Ser Leu Ser Gly Pro Thr Thr Ala Ser Pro Leu Leu Val Leu Phe
    850                 855                 860                 
Thr Ile Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn Met His
865                 870                 875                 880 
His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly
                885                 890                 895     
Leu Leu Arg Pro Val Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser
            900                 905                 910         
Gly Cys Arg Leu Thr Leu Leu Arg Pro Lys Lys Asp Gly Ala Ala Thr
        915                 920                 925             
Lys Val Asp Ala Ile Cys Thr Tyr Arg Pro Asp Pro Lys Ser Pro Gly
    930                 935                 940                 
Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Ser
945                 950                 955                 960 
Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val
                965                 970                 975     
Asn Gly Phe Thr Gln Arg Ser Ser Val Pro Thr Thr Ser Ile Pro Gly
            980                 985                 990         
Thr Pro Thr Val Asp Leu Gly Thr Ser Gly Thr Pro Val Ser Lys Pro
        995                 1000                1005            
Gly Pro Ser Ala Ala Ser Pro Leu Leu Val Leu Phe Thr Leu Asn Phe
    1010                1015                1020                
Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn Met Gln His Pro Gly Ser
1025                1030                1035                1040
Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Ser
                1045                1050                1055    
Leu Phe Lys Ser Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu
            1060                1065                1070        
Thr Leu Leu Arg Pro Glu Lys Asp Gly Thr Ala Thr Gly Val Asp Ala
        1075                1080                1085            
Ile Cys Thr His His Pro Asp Pro Lys Ser Pro Arg Leu Asp Arg Glu
    1090                1095                1100                
Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Asn Ile Thr Glu Leu
1105                1110                1115                1120
Gly Pro Tyr Ala Leu Asp Asn Asp Ser Leu Phe Val Asn Gly Phe Thr
                1125                1130                1135    
His Arg Ser Ser Val Ser Thr Thr Ser Thr Pro Gly Thr Pro Thr Val
            1140                1145                1150        
Tyr Leu Gly Ala Ser Lys Thr Pro Ala Ser Ile Phe Gly Pro Ser Ala
        1155                1160                1165            
Ala Ser His Leu Leu Ile Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn
    1170                1175                1180                
Leu Arg Tyr Glu Glu Asn Met Trp Pro Gly Ser Arg Lys Phe Asn Thr
1185                1190                1195                1200
Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro Leu Phe Lys Asn Thr
                1205                1210                1215    
Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro
            1220                1225                1230        
Glu Lys Asp Gly Glu Ala Thr Gly Val Asp Ala Ile Cys Thr His Arg
        1235                1240                1245            
Pro Asp Pro Thr Gly Pro Gly Leu Asp Arg Glu Gln Leu Tyr Leu Glu
    1250                1255                1260                
Leu Ser Gln Leu Thr His Ser Ile Thr Glu Leu Gly Pro Tyr Thr Leu
1265                1270                1275                1280
Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser Val
                1285                1290                1295    
Pro Thr Thr Ser Thr Gly Val Val Ser Glu Glu Pro Phe Thr Leu Asn
            1300                1305                1310        
Phe Thr Ile Asn Asn Leu Arg Tyr Met Ala Asp Met Gly Gln Pro Gly
        1315                1320                1325            
Ser Leu Lys Phe Asn Ile Thr Asp Asn Val Met Gln His Leu Leu Ser
    1330                1335                1340                
Pro Leu Phe Gln Arg Ser Ser Leu Gly Ala Arg Tyr Thr Gly Cys Arg
1345                1350                1355                1360
Val Ile Ala Leu Arg Ser Val Lys Asn Gly Ala Glu Thr Arg Val Asp
                1365                1370                1375    
Leu Leu Cys Thr Tyr Leu Gln Pro Leu Ser Gly Pro Gly Leu Pro Ile
            1380                1385                1390        
Lys Gln Val Phe His Glu Leu Ser Gln Gln Thr His Gly Ile Thr Arg
        1395                1400                1405            
Leu Gly Pro Tyr Ser Leu Asp Lys Asp Ser Leu Tyr Leu Asn Gly Tyr
    1410                1415                1420                
Asn Glu Pro Gly Pro Asp Glu Pro Pro Thr Thr Pro Lys Pro Ala Thr
1425                1430                1435                1440
Thr Phe Leu Pro Pro Leu Ser Glu Ala Thr Thr Ala Met Gly Tyr His
                1445                1450                1455    
Leu Lys Thr Leu Thr Leu Asn Phe Thr Ile Ser Asn Leu Gln Tyr Ser
            1460                1465                1470        
Pro Asp Met Gly Lys Gly Ser Ala Thr Phe Asn Ser Thr Glu Gly Val
        1475                1480                1485            
Leu Gln His Leu Leu Arg Pro Leu Phe Gln Lys Ser Ser Met Gly Pro
    1490                1495                1500                
Phe Tyr Leu Gly Cys Gln Leu Ile Ser Leu Arg Pro Glu Lys Asp Gly
1505                1510                1515                1520
Ala Ala Thr Gly Val Asp Thr Thr Cys Thr Tyr His Pro Asp Pro Val
                1525                1530                1535    
Gly Pro Gly Leu Asp Ile Gln Gln Leu Tyr Trp Glu Leu Ser Gln Leu
            1540                1545                1550        
Thr His Gly Val Thr Gln Leu Gly Phe Tyr Val Leu Asp Arg Asp Ser
        1555                1560                1565            
Leu Phe Ile Asn Gly Tyr Ala Pro Gln Asn Leu Ser Ile Arg Gly Glu
    1570                1575                1580                
Tyr Gln Ile Asn Phe His Ile Val Asn Trp Asn Leu Ser Asn Pro Asp
1585                1590                1595                1600
Pro Thr Ser Ser Glu Tyr Ile Thr Leu Leu Arg Asp Ile Gln Asp Lys
                1605                1610                1615    
Val Thr Thr Leu Tyr Lys Gly Ser Gln Leu His Asp Thr Phe Arg Phe
            1620                1625                1630        
Cys Leu Val Thr Asn Leu Thr Met Asp Ser Val Leu Val Thr Val Lys
        1635                1640                1645            
Ala Leu Phe Ser Ser Asn Leu Asp Pro Ser Leu Val Glu Gln Val Phe
    1650                1655                1660                
Leu Asp Lys Thr Leu Asn Ala Ser Phe His Trp Leu Gly Ser Thr Tyr
1665                1670                1675                1680
Gln Leu Val Asp Ile His Val Thr Glu Met Glu Ser Ser Val Tyr Gln
                1685                1690                1695    
Pro Thr Ser Ser Ser Ser Thr Gln His Phe Tyr Pro Asn Phe Thr Ile
            1700                1705                1710        
Thr Asn Leu Pro Tyr Ser Gln Asp Lys Ala Gln Pro Gly Thr Thr Asn
        1715                1720                1725            
Tyr Gln Arg Asn Lys Arg Asn Ile Glu Asp Ala Leu Asn Gln Leu Phe
    1730                1735                1740                
Arg Asn Ser Ser Ile Lys Ser Tyr Phe Ser Asp Cys Gln Val Ser Thr
1745                1750                1755                1760
Phe Arg Ser Val Pro Asn Arg His His Thr Gly Val Asp Ser Leu Cys
                1765                1770                1775    
Asn Phe Ser Pro Leu Ala Arg Arg Val Asp Arg Val Ala Ile Tyr Glu
            1780                1785                1790        
Glu Phe Leu Arg Met Thr Arg Asn Gly Thr Gln Leu Gln Asn Phe Thr
        1795                1800                1805            
Leu Asp Arg Ser Ser Val Leu Val Asp Gly Tyr Ser Pro Asn Arg Asn
    1810                1815                1820                
Glu Pro Leu Thr Gly Asn Ser Asp Leu Pro Phe Trp Ala Val Ile Leu
1825                1830                1835                1840
Ile Gly Leu Ala Gly Leu Leu Gly Leu Ile Thr Cys Leu Ile Cys Gly
                1845                1850                1855    
Val Leu Val Thr Thr Arg Arg Arg Lys Lys Glu Gly Glu Tyr Asn Val
            1860                1865                1870        
Gln Gln Gln Cys Pro Gly Tyr Tyr Gln Ser His Leu Asp Leu Glu Asp
        1875                1880                1885            
Leu Gln
    1890


<210>  6593
<211>  22152
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (13877)..(13878)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13880)..(13880)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13887)..(13887)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13890)..(13891)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13893)..(13893)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13903)..(13903)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13913)..(13914)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13916)..(13916)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13928)..(13929)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13938)..(13938)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13940)..(13941)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14569)..(14571)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14575)..(14575)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14579)..(14579)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14581)..(14581)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14587)..(14591)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14593)..(14594)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14725)..(14727)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14731)..(14731)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14735)..(14735)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14737)..(14737)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14743)..(14747)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14749)..(14750)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15661)..(15663)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15667)..(15667)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15671)..(15671)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15673)..(15673)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15679)..(15683)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15685)..(15686)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15972)..(15974)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15978)..(15978)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15982)..(15982)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15984)..(15984)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15990)..(15994)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15996)..(15997)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16008)..(16008)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16015)..(16015)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16017)..(16017)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16021)..(16021)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16025)..(16025)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16034)..(16034)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16037)..(16037)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16040)..(16040)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16046)..(16046)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16051)..(16051)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16053)..(16055)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16058)..(16058)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16062)..(16063)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16065)..(16065)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16072)..(16072)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16075)..(16076)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16078)..(16078)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16088)..(16088)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16268)..(16269)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16278)..(16278)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16280)..(16281)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16373)..(16374)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16376)..(16376)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16383)..(16383)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16386)..(16387)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16389)..(16389)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16399)..(16399)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16409)..(16410)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16412)..(16412)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16424)..(16425)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16434)..(16434)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16436)..(16437)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16439)..(16441)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16445)..(16445)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16449)..(16449)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16451)..(16451)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16457)..(16461)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16463)..(16464)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16841)..(16842)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16844)..(16844)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16851)..(16851)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16854)..(16855)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16857)..(16857)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16867)..(16867)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16877)..(16878)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16880)..(16880)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16892)..(16893)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16902)..(16902)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16904)..(16905)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16907)..(16909)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16913)..(16913)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16917)..(16917)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16919)..(16919)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16925)..(16929)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16931)..(16932)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17465)..(17466)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17468)..(17468)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17475)..(17475)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17478)..(17479)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17481)..(17481)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17491)..(17491)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17501)..(17502)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17504)..(17504)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17516)..(17517)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17526)..(17526)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17528)..(17529)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17531)..(17533)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17537)..(17537)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17541)..(17541)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17543)..(17543)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17549)..(17553)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17555)..(17556)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17567)..(17567)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17574)..(17574)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17576)..(17576)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17580)..(17580)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17584)..(17584)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17593)..(17593)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17596)..(17596)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17599)..(17599)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17605)..(17605)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17610)..(17610)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17612)..(17614)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17617)..(17617)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17621)..(17622)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17624)..(17624)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17631)..(17631)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17777)..(17778)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17780)..(17780)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17787)..(17787)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17790)..(17791)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17793)..(17793)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17803)..(17803)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17813)..(17814)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17816)..(17816)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17828)..(17829)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17838)..(17838)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17840)..(17841)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17843)..(17845)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17849)..(17849)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17853)..(17853)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17855)..(17855)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17861)..(17865)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17867)..(17868)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17879)..(17879)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17886)..(17886)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17888)..(17888)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17892)..(17892)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17896)..(17896)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17905)..(17905)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17908)..(17908)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17911)..(17911)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17917)..(17917)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17922)..(17922)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17924)..(17926)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17929)..(17929)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17933)..(17934)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17936)..(17936)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17943)..(17943)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17946)..(17947)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17949)..(17949)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17959)..(17959)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18089)..(18090)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18092)..(18092)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18099)..(18099)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18102)..(18103)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18105)..(18105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18115)..(18115)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18125)..(18126)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18128)..(18128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18140)..(18141)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18150)..(18150)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18152)..(18153)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18155)..(18157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18161)..(18161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18165)..(18165)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18167)..(18167)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18173)..(18177)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18179)..(18180)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18191)..(18191)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18198)..(18198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18200)..(18200)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18204)..(18204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18208)..(18208)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18217)..(18217)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18220)..(18220)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18223)..(18223)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18229)..(18229)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18234)..(18234)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18236)..(18238)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18241)..(18241)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18245)..(18246)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18248)..(18248)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18255)..(18255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18258)..(18259)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18261)..(18261)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18271)..(18271)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18401)..(18402)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18404)..(18404)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18411)..(18411)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18414)..(18415)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18417)..(18417)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18427)..(18427)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18437)..(18438)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18440)..(18440)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18452)..(18453)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18462)..(18462)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18464)..(18465)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18467)..(18469)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18473)..(18473)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18477)..(18477)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18479)..(18479)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18485)..(18489)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18491)..(18492)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18503)..(18503)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18510)..(18510)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18512)..(18512)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18516)..(18516)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18520)..(18520)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18529)..(18529)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18532)..(18532)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18535)..(18535)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18541)..(18541)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18546)..(18546)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18548)..(18550)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18553)..(18553)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18557)..(18558)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18560)..(18560)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18567)..(18567)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18570)..(18571)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18573)..(18573)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18583)..(18583)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18713)..(18714)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18716)..(18716)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18723)..(18723)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18726)..(18727)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18729)..(18729)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18739)..(18739)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18749)..(18750)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18752)..(18752)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18764)..(18765)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18774)..(18774)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18776)..(18777)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18779)..(18781)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18785)..(18785)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18789)..(18789)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18791)..(18791)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18797)..(18801)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18803)..(18804)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18815)..(18815)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18822)..(18822)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18824)..(18824)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18828)..(18828)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18832)..(18832)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18841)..(18841)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18844)..(18844)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18847)..(18847)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18853)..(18853)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18858)..(18858)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18860)..(18862)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18865)..(18865)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18869)..(18870)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18872)..(18872)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18879)..(18879)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18882)..(18883)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18885)..(18885)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18895)..(18895)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19091)..(19093)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19097)..(19097)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19101)..(19101)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19103)..(19103)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19109)..(19113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19115)..(19116)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19127)..(19127)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19134)..(19134)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19136)..(19136)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19140)..(19140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19144)..(19144)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19153)..(19153)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19156)..(19156)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19159)..(19159)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19165)..(19165)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19170)..(19170)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19172)..(19174)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19177)..(19177)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19181)..(19182)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19184)..(19184)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19191)..(19191)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19194)..(19195)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19197)..(19197)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19207)..(19207)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19337)..(19338)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19340)..(19340)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19347)..(19347)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19350)..(19351)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19353)..(19353)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19363)..(19363)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19373)..(19374)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19376)..(19376)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19388)..(19389)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19398)..(19398)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19400)..(19401)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19403)..(19405)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19409)..(19409)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19413)..(19413)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19415)..(19415)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19421)..(19425)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19427)..(19428)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19439)..(19439)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19446)..(19446)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19448)..(19448)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19452)..(19452)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19456)..(19456)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19465)..(19465)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19468)..(19468)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19471)..(19471)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19477)..(19477)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19482)..(19482)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19484)..(19486)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19489)..(19489)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19493)..(19494)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19496)..(19496)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19503)..(19503)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19506)..(19507)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19509)..(19509)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19519)..(19519)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19649)..(19650)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19652)..(19652)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19659)..(19659)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19662)..(19663)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19665)..(19665)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19675)..(19675)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19685)..(19686)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19688)..(19688)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19700)..(19701)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19710)..(19710)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19712)..(19713)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19715)..(19717)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19721)..(19721)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19725)..(19725)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19727)..(19727)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19733)..(19737)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19739)..(19740)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19751)..(19751)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19758)..(19758)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19760)..(19760)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19764)..(19764)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19768)..(19768)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19777)..(19777)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19780)..(19780)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19783)..(19783)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19789)..(19789)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19794)..(19794)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19796)..(19798)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19801)..(19801)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19805)..(19806)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19808)..(19808)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19815)..(19815)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19818)..(19819)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19821)..(19821)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19831)..(19831)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19960)..(19961)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19963)..(19963)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19970)..(19970)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19973)..(19974)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19976)..(19976)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19986)..(19986)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19996)..(19997)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19999)..(19999)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20011)..(20012)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20021)..(20021)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20023)..(20024)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20026)..(20028)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20032)..(20032)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20036)..(20036)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20038)..(20038)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20044)..(20048)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20050)..(20051)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20062)..(20062)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20069)..(20069)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20071)..(20071)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20075)..(20075)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20079)..(20079)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20088)..(20088)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20091)..(20091)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20094)..(20094)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20100)..(20100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20105)..(20105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20107)..(20109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20112)..(20112)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20116)..(20117)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20119)..(20119)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20126)..(20126)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20129)..(20130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20132)..(20132)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20142)..(20142)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20272)..(20273)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20275)..(20275)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20282)..(20282)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20285)..(20286)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20288)..(20288)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20298)..(20298)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20308)..(20309)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20311)..(20311)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20323)..(20324)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20333)..(20333)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20335)..(20336)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20806)..(20808)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20812)..(20812)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20816)..(20816)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20818)..(20818)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20824)..(20828)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20830)..(20831)
<223>  Xaa can be any naturally occurring amino acid

<400>  6593

Met Leu Lys Pro Ser Gly Leu Pro Gly Ser Ser Ser Pro Thr Arg Ser 
1               5                   10                  15      


Leu Met Thr Gly Ser Arg Ser Thr Lys Ala Thr Pro Glu Met Asp Ser 
            20                  25                  30          


Gly Leu Thr Gly Ala Thr Leu Ser Pro Lys Thr Ser Thr Gly Ala Ile 
        35                  40                  45              


Val Val Thr Glu His Thr Leu Pro Phe Thr Ser Pro Asp Lys Thr Leu 
    50                  55                  60                  


Ala Ser Pro Thr Ser Ser Val Val Gly Arg Thr Thr Gln Ser Leu Gly 
65                  70                  75                  80  


Val Met Ser Ser Ala Leu Pro Glu Ser Thr Ser Arg Gly Met Thr His 
                85                  90                  95      


Ser Glu Gln Arg Thr Ser Pro Ser Leu Ser Pro Gln Val Asn Gly Thr 
            100                 105                 110         


Pro Ser Arg Asn Tyr Pro Ala Thr Ser Met Val Ser Gly Leu Ser Ser 
        115                 120                 125             


Pro Arg Thr Arg Thr Ser Ser Thr Glu Gly Asn Phe Thr Lys Glu Ala 
    130                 135                 140                 


Ser Thr Tyr Thr Leu Thr Val Glu Thr Thr Ser Gly Pro Val Thr Glu 
145                 150                 155                 160 


Lys Tyr Thr Val Pro Thr Glu Thr Ser Thr Thr Glu Gly Asp Ser Thr 
                165                 170                 175     


Glu Thr Pro Trp Asp Thr Arg Tyr Ile Pro Val Lys Ile Thr Ser Pro 
            180                 185                 190         


Met Lys Thr Phe Ala Asp Ser Thr Ala Ser Lys Glu Asn Ala Pro Val 
        195                 200                 205             


Ser Met Thr Pro Ala Glu Thr Thr Val Thr Asp Ser His Thr Pro Gly 
    210                 215                 220                 


Arg Thr Asn Pro Ser Phe Gly Thr Leu Tyr Ser Ser Phe Leu Asp Leu 
225                 230                 235                 240 


Ser Pro Lys Gly Thr Pro Asn Ser Arg Gly Glu Thr Ser Leu Glu Leu 
                245                 250                 255     


Ile Leu Ser Thr Thr Gly Tyr Pro Phe Ser Ser Pro Glu Pro Gly Ser 
            260                 265                 270         


Ala Gly His Ser Arg Ile Ser Thr Ser Ala Pro Leu Ser Ser Ser Ala 
        275                 280                 285             


Ser Val Leu Asp Asn Lys Ile Ser Glu Thr Ser Ile Phe Ser Gly Gln 
    290                 295                 300                 


Ser Leu Thr Ser Pro Leu Ser Pro Gly Val Pro Glu Ala Arg Ala Ser 
305                 310                 315                 320 


Thr Met Pro Asn Ser Ala Ile Pro Phe Ser Met Thr Leu Ser Asn Ala 
                325                 330                 335     


Glu Thr Ser Ala Glu Arg Val Arg Ser Thr Ile Ser Ser Leu Gly Thr 
            340                 345                 350         


Pro Ser Ile Ser Thr Lys Gln Thr Ala Glu Thr Ile Leu Thr Phe His 
        355                 360                 365             


Ala Phe Ala Glu Thr Met Asp Ile Pro Ser Thr His Ile Ala Lys Thr 
    370                 375                 380                 


Leu Ala Ser Glu Trp Leu Gly Ser Pro Gly Thr Leu Gly Gly Thr Ser 
385                 390                 395                 400 


Thr Ser Ala Leu Thr Thr Thr Ser Pro Ser Thr Thr Leu Val Ser Glu 
                405                 410                 415     


Glu Thr Asn Thr His His Ser Thr Ser Gly Lys Glu Thr Glu Gly Thr 
            420                 425                 430         


Leu Asn Thr Ser Met Thr Pro Leu Glu Thr Ser Ala Pro Gly Glu Glu 
        435                 440                 445             


Ser Glu Met Thr Ala Thr Leu Val Pro Thr Leu Gly Phe Thr Thr Leu 
    450                 455                 460                 


Asp Ser Lys Ile Arg Ser Pro Ser Gln Val Ser Ser Ser His Pro Thr 
465                 470                 475                 480 


Arg Glu Leu Arg Thr Thr Gly Ser Thr Ser Gly Arg Gln Ser Ser Ser 
                485                 490                 495     


Thr Ala Ala His Gly Ser Ser Asp Ile Leu Arg Ala Thr Thr Ser Ser 
            500                 505                 510         


Thr Ser Lys Ala Ser Ser Trp Thr Ser Glu Ser Thr Ala Gln Gln Phe 
        515                 520                 525             


Ser Glu Pro Gln His Thr Gln Trp Val Glu Thr Ser Pro Ser Met Lys 
    530                 535                 540                 


Thr Glu Arg Pro Pro Ala Ser Thr Ser Val Ala Ala Pro Ile Thr Thr 
545                 550                 555                 560 


Ser Val Pro Ser Val Val Ser Gly Phe Thr Thr Leu Lys Thr Ser Ser 
                565                 570                 575     


Thr Lys Gly Ile Trp Leu Glu Glu Thr Ser Ala Asp Thr Leu Ile Gly 
            580                 585                 590         


Glu Ser Thr Ala Gly Pro Thr Thr His Gln Phe Ala Val Pro Thr Gly 
        595                 600                 605             


Ile Ser Met Thr Gly Gly Ser Ser Thr Arg Gly Ser Gln Gly Thr Thr 
    610                 615                 620                 


His Leu Leu Thr Arg Ala Thr Ala Ser Ser Glu Thr Ser Ala Asp Leu 
625                 630                 635                 640 


Thr Leu Ala Thr Asn Gly Val Pro Val Ser Val Ser Pro Ala Val Ser 
                645                 650                 655     


Lys Thr Ala Ala Gly Ser Ser Pro Pro Gly Gly Thr Lys Pro Ser Tyr 
            660                 665                 670         


Thr Met Val Ser Ser Val Ile Pro Glu Thr Ser Ser Leu Gln Ser Ser 
        675                 680                 685             


Ala Phe Arg Glu Gly Thr Ser Leu Gly Leu Thr Pro Leu Asn Thr Arg 
    690                 695                 700                 


His Pro Phe Ser Ser Pro Glu Pro Asp Ser Ala Gly His Thr Lys Ile 
705                 710                 715                 720 


Ser Thr Ser Ile Pro Leu Leu Ser Ser Ala Ser Val Leu Glu Asp Lys 
                725                 730                 735     


Val Ser Ala Thr Ser Thr Phe Ser His His Lys Ala Thr Ser Ser Ile 
            740                 745                 750         


Thr Thr Gly Thr Pro Glu Ile Ser Thr Lys Thr Lys Pro Ser Ser Ala 
        755                 760                 765             


Val Leu Ser Ser Met Thr Leu Ser Asn Ala Ala Thr Ser Pro Glu Arg 
    770                 775                 780                 


Val Arg Asn Ala Thr Ser Pro Leu Thr His Pro Ser Pro Ser Gly Glu 
785                 790                 795                 800 


Glu Thr Ala Gly Ser Val Leu Thr Leu Ser Thr Ser Ala Glu Thr Thr 
                805                 810                 815     


Asp Ser Pro Asn Ile His Pro Thr Gly Thr Leu Thr Ser Glu Ser Ser 
            820                 825                 830         


Glu Ser Pro Ser Thr Leu Ser Leu Pro Ser Val Ser Gly Val Lys Thr 
        835                 840                 845             


Thr Phe Ser Ser Ser Thr Pro Ser Thr His Leu Phe Thr Ser Gly Glu 
    850                 855                 860                 


Glu Thr Glu Glu Thr Ser Asn Pro Ser Val Ser Gln Pro Glu Thr Ser 
865                 870                 875                 880 


Val Ser Arg Val Arg Thr Thr Leu Ala Ser Thr Ser Val Pro Thr Pro 
                885                 890                 895     


Val Phe Pro Thr Met Asp Thr Trp Pro Thr Arg Ser Ala Gln Phe Ser 
            900                 905                 910         


Ser Ser His Leu Val Ser Glu Leu Arg Ala Thr Ser Ser Thr Ser Val 
        915                 920                 925             


Thr Asn Ser Thr Gly Ser Ala Leu Pro Lys Ile Ser His Leu Thr Gly 
    930                 935                 940                 


Thr Ala Thr Met Ser Gln Thr Asn Arg Asp Thr Phe Asn Asp Ser Ala 
945                 950                 955                 960 


Ala Pro Gln Ser Thr Thr Trp Pro Glu Thr Ser Pro Arg Phe Lys Thr 
                965                 970                 975     


Gly Leu Pro Ser Ala Thr Thr Thr Val Ser Thr Ser Ala Thr Ser Leu 
            980                 985                 990         


Ser Ala Thr Val Met Val Ser Lys  Phe Thr Ser Pro Ala  Thr Ser Ser 
        995                 1000                 1005             


Met Glu  Ala Thr Ser Ile Arg  Glu Pro Ser Thr Thr  Ile Leu Thr 
    1010                 1015                 1020             


Thr Glu  Thr Thr Asn Gly Pro  Gly Ser Met Ala Val  Ala Ser Thr 
    1025                 1030                 1035             


Asn Ile  Pro Ile Gly Lys Gly  Tyr Ile Thr Glu Gly  Arg Leu Asp 
    1040                 1045                 1050             


Thr Ser  His Leu Pro Ile Gly  Thr Thr Ala Ser Ser  Glu Thr Ser 
    1055                 1060                 1065             


Met Asp  Phe Thr Met Ala Lys  Glu Ser Val Ser Met  Ser Val Ser 
    1070                 1075                 1080             


Pro Ser  Gln Ser Met Asp Ala  Ala Gly Ser Ser Thr  Pro Gly Arg 
    1085                 1090                 1095             


Thr Ser  Gln Phe Val Asp Thr  Phe Ser Asp Asp Val  Tyr His Leu 
    1100                 1105                 1110             


Thr Ser  Arg Glu Ile Thr Ile  Pro Arg Asp Gly Thr  Ser Ser Ala 
    1115                 1120                 1125             


Leu Thr  Pro Gln Met Thr Ala  Thr His Pro Pro Ser  Pro Asp Pro 
    1130                 1135                 1140             


Gly Ser  Ala Arg Ser Thr Trp  Leu Gly Ile Leu Ser  Ser Ser Pro 
    1145                 1150                 1155             


Ser Ser  Pro Thr Pro Lys Val  Thr Met Ser Ser Thr  Phe Ser Thr 
    1160                 1165                 1170             


Gln Arg  Val Thr Thr Ser Met  Ile Met Asp Thr Val  Glu Thr Ser 
    1175                 1180                 1185             


Arg Trp  Asn Met Pro Asn Leu  Pro Ser Thr Thr Ser  Leu Thr Pro 
    1190                 1195                 1200             


Ser Asn  Ile Pro Thr Ser Gly  Ala Ile Gly Lys Ser  Thr Leu Val 
    1205                 1210                 1215             


Pro Leu  Asp Thr Pro Ser Pro  Ala Thr Ser Leu Glu  Ala Ser Glu 
    1220                 1225                 1230             


Gly Gly  Leu Pro Thr Leu Ser  Thr Tyr Pro Glu Ser  Thr Asn Thr 
    1235                 1240                 1245             


Pro Ser  Ile His Leu Gly Ala  His Ala Ser Ser Glu  Ser Pro Ser 
    1250                 1255                 1260             


Thr Ile  Lys Leu Thr Met Ala  Ser Val Val Lys Pro  Gly Ser Tyr 
    1265                 1270                 1275             


Thr Pro  Leu Thr Phe Pro Ser  Ile Glu Thr His Ile  His Val Ser 
    1280                 1285                 1290             


Thr Ala  Arg Met Ala Tyr Ser  Ser Gly Ser Ser Pro  Glu Met Thr 
    1295                 1300                 1305             


Ala Pro  Gly Glu Thr Asn Thr  Gly Ser Thr Trp Asp  Pro Thr Thr 
    1310                 1315                 1320             


Tyr Ile  Thr Thr Thr Asp Pro  Lys Asp Thr Ser Ser  Ala Gln Val 
    1325                 1330                 1335             


Ser Thr  Pro His Ser Val Arg  Thr Leu Arg Thr Thr  Glu Asn His 
    1340                 1345                 1350             


Pro Lys  Thr Glu Ser Ala Thr  Pro Ala Ala Tyr Ser  Gly Ser Pro 
    1355                 1360                 1365             


Lys Ile  Ser Ser Ser Pro Asn  Leu Thr Ser Pro Ala  Thr Lys Ala 
    1370                 1375                 1380             


Trp Thr  Ile Thr Asp Thr Thr  Glu His Ser Thr Gln  Leu His Tyr 
    1385                 1390                 1395             


Thr Lys  Leu Ala Glu Lys Ser  Ser Gly Phe Glu Thr  Gln Ser Ala 
    1400                 1405                 1410             


Pro Gly  Pro Val Ser Val Val  Ile Pro Thr Ser Pro  Thr Ile Gly 
    1415                 1420                 1425             


Ser Ser  Thr Leu Glu Leu Thr  Ser Asp Val Pro Gly  Glu Pro Leu 
    1430                 1435                 1440             


Val Leu  Ala Pro Ser Glu Gln  Thr Thr Ile Thr Leu  Pro Met Ala 
    1445                 1450                 1455             


Thr Trp  Leu Ser Thr Ser Leu  Thr Glu Glu Met Ala  Ser Thr Asp 
    1460                 1465                 1470             


Leu Asp  Ile Ser Ser Pro Ser  Ser Pro Met Ser Thr  Phe Ala Ile 
    1475                 1480                 1485             


Phe Pro  Pro Met Ser Thr Pro  Ser His Glu Leu Ser  Lys Ser Glu 
    1490                 1495                 1500             


Ala Asp  Thr Ser Ala Ile Arg  Asn Thr Asp Ser Thr  Thr Leu Asp 
    1505                 1510                 1515             


Gln His  Leu Gly Ile Arg Ser  Leu Gly Arg Thr Gly  Asp Leu Thr 
    1520                 1525                 1530             


Thr Val  Pro Ile Thr Pro Leu  Thr Thr Thr Trp Thr  Ser Val Ile 
    1535                 1540                 1545             


Glu His  Ser Thr Gln Ala Gln  Asp Thr Leu Ser Ala  Thr Met Ser 
    1550                 1555                 1560             


Pro Thr  His Val Thr Gln Ser  Leu Lys Asp Gln Thr  Ser Ile Pro 
    1565                 1570                 1575             


Ala Ser  Ala Ser Pro Ser His  Leu Thr Glu Val Tyr  Pro Glu Leu 
    1580                 1585                 1590             


Gly Thr  Gln Gly Arg Ser Ser  Ser Glu Ala Thr Thr  Phe Trp Lys 
    1595                 1600                 1605             


Pro Ser  Thr Asp Thr Leu Ser  Arg Glu Ile Glu Thr  Gly Pro Thr 
    1610                 1615                 1620             


Asn Ile  Gln Ser Thr Pro Pro  Met Asp Asn Thr Thr  Thr Gly Ser 
    1625                 1630                 1635             


Ser Ser  Ser Gly Val Thr Leu  Gly Ile Ala His Leu  Pro Ile Gly 
    1640                 1645                 1650             


Thr Ser  Ser Pro Ala Glu Thr  Ser Thr Asn Met Ala  Leu Glu Arg 
    1655                 1660                 1665             


Arg Ser  Ser Thr Ala Thr Val  Ser Met Ala Gly Thr  Met Gly Leu 
    1670                 1675                 1680             


Leu Val  Thr Ser Ala Pro Gly  Arg Ser Ile Ser Gln  Ser Leu Gly 
    1685                 1690                 1695             


Arg Val  Ser Ser Val Leu Ser  Glu Ser Thr Thr Glu  Gly Val Thr 
    1700                 1705                 1710             


Asp Ser  Ser Lys Gly Ser Ser  Pro Arg Leu Asn Thr  Gln Gly Asn 
    1715                 1720                 1725             


Thr Ala  Leu Ser Ser Ser Leu  Glu Pro Ser Tyr Ala  Glu Gly Ser 
    1730                 1735                 1740             


Gln Met  Ser Thr Ser Ile Pro  Leu Thr Ser Ser Pro  Thr Thr Pro 
    1745                 1750                 1755             


Asp Val  Glu Phe Ile Gly Gly  Ser Thr Phe Trp Thr  Lys Glu Val 
    1760                 1765                 1770             


Thr Thr  Val Met Thr Ser Asp  Ile Ser Lys Ser Ser  Ala Arg Thr 
    1775                 1780                 1785             


Glu Ser  Ser Ser Ala Thr Leu  Met Ser Thr Ala Leu  Gly Ser Thr 
    1790                 1795                 1800             


Glu Asn  Thr Gly Lys Glu Lys  Leu Arg Thr Ala Ser  Met Asp Leu 
    1805                 1810                 1815             


Pro Ser  Pro Thr Pro Ser Met  Glu Val Thr Pro Trp  Ile Ser Leu 
    1820                 1825                 1830             


Thr Leu  Ser Asn Ala Pro Asn  Thr Thr Asp Ser Leu  Asp Leu Ser 
    1835                 1840                 1845             


His Gly  Val His Thr Ser Ser  Ala Gly Thr Leu Ala  Thr Asp Arg 
    1850                 1855                 1860             


Ser Leu  Asn Thr Gly Val Thr  Arg Ala Ser Arg Leu  Glu Asn Gly 
    1865                 1870                 1875             


Ser Asp  Thr Ser Ser Lys Ser  Leu Ser Met Gly Asn  Ser Thr His 
    1880                 1885                 1890             


Thr Ser  Met Thr Asp Thr Glu  Lys Ser Glu Val Ser  Ser Ser Ile 
    1895                 1900                 1905             


His Pro  Arg Pro Glu Thr Ser  Ala Pro Gly Ala Glu  Thr Thr Leu 
    1910                 1915                 1920             


Thr Ser  Thr Pro Gly Asn Arg  Ala Ile Ser Leu Thr  Leu Pro Phe 
    1925                 1930                 1935             


Ser Ser  Ile Pro Val Glu Glu  Val Ile Ser Thr Gly  Ile Thr Ser 
    1940                 1945                 1950             


Gly Pro  Asp Ile Asn Ser Ala  Pro Met Thr His Ser  Pro Ile Thr 
    1955                 1960                 1965             


Pro Pro  Thr Ile Val Trp Thr  Ser Thr Gly Thr Ile  Glu Gln Ser 
    1970                 1975                 1980             


Thr Gln  Pro Leu His Ala Val  Ser Ser Glu Lys Val  Ser Val Gln 
    1985                 1990                 1995             


Thr Gln  Ser Thr Pro Tyr Val  Asn Ser Val Ala Val  Ser Ala Ser 
    2000                 2005                 2010             


Pro Thr  His Glu Asn Ser Val  Ser Ser Gly Ser Ser  Thr Ser Ser 
    2015                 2020                 2025             


Pro Tyr  Ser Ser Ala Ser Leu  Glu Ser Leu Asp Ser  Thr Ile Ser 
    2030                 2035                 2040             


Arg Arg  Asn Ala Ile Thr Ser  Trp Leu Trp Asp Leu  Thr Thr Ser 
    2045                 2050                 2055             


Leu Pro  Thr Thr Thr Trp Pro  Ser Thr Ser Leu Ser  Glu Ala Leu 
    2060                 2065                 2070             


Ser Ser  Gly His Ser Gly Val  Ser Asn Pro Ser Ser  Thr Thr Thr 
    2075                 2080                 2085             


Glu Phe  Pro Leu Phe Ser Ala  Ala Ser Thr Ser Ala  Ala Lys Gln 
    2090                 2095                 2100             


Arg Asn  Pro Glu Thr Glu Thr  His Gly Pro Gln Asn  Thr Ala Ala 
    2105                 2110                 2115             


Ser Thr  Leu Asn Thr Asp Ala  Ser Ser Val Thr Gly  Leu Ser Glu 
    2120                 2125                 2130             


Thr Pro  Val Gly Ala Ser Ile  Ser Ser Glu Val Pro  Leu Pro Met 
    2135                 2140                 2145             


Ala Ile  Thr Ser Arg Ser Asp  Val Ser Gly Leu Thr  Ser Glu Ser 
    2150                 2155                 2160             


Thr Ala  Asn Pro Ser Leu Gly  Thr Ala Ser Ser Ala  Gly Thr Lys 
    2165                 2170                 2175             


Leu Thr  Arg Thr Ile Ser Leu  Pro Thr Ser Glu Ser  Leu Val Ser 
    2180                 2185                 2190             


Phe Arg  Met Asn Lys Asp Pro  Trp Thr Val Ser Ile  Pro Leu Gly 
    2195                 2200                 2205             


Ser His  Pro Thr Thr Asn Thr  Glu Thr Ser Ile Pro  Val Asn Ser 
    2210                 2215                 2220             


Ala Gly  Pro Pro Gly Leu Ser  Thr Val Ala Ser Asp  Val Ile Asp 
    2225                 2230                 2235             


Thr Pro  Ser Asp Gly Ala Glu  Ser Ile Pro Thr Val  Ser Phe Ser 
    2240                 2245                 2250             


Pro Ser  Pro Asp Thr Glu Val  Thr Thr Ile Ser His  Phe Pro Glu 
    2255                 2260                 2265             


Lys Thr  Thr His Ser Phe Arg  Thr Ile Ser Ser Leu  Thr His Glu 
    2270                 2275                 2280             


Leu Thr  Ser Arg Val Thr Pro  Ile Pro Gly Asp Trp  Met Ser Ser 
    2285                 2290                 2295             


Ala Met  Ser Thr Lys Pro Thr  Gly Ala Ser Pro Ser  Ile Thr Leu 
    2300                 2305                 2310             


Gly Glu  Arg Arg Thr Ile Thr  Ser Ala Ala Pro Thr  Thr Ser Pro 
    2315                 2320                 2325             


Ile Val  Leu Thr Ala Ser Phe  Thr Glu Thr Ser Thr  Val Ser Leu 
    2330                 2335                 2340             


Asp Asn  Glu Thr Thr Val Lys  Thr Ser Asp Ile Leu  Asp Ala Arg 
    2345                 2350                 2355             


Lys Thr  Asn Glu Leu Pro Ser  Asp Ser Ser Ser Ser  Ser Asp Leu 
    2360                 2365                 2370             


Ile Asn  Thr Ser Ile Ala Ser  Ser Thr Met Asp Val  Thr Lys Thr 
    2375                 2380                 2385             


Ala Ser  Ile Ser Pro Thr Ser  Ile Ser Gly Met Thr  Ala Ser Ser 
    2390                 2395                 2400             


Ser Pro  Ser Leu Phe Ser Ser  Asp Arg Pro Gln Val  Pro Thr Ser 
    2405                 2410                 2415             


Thr Thr  Glu Thr Asn Thr Ala  Thr Ser Pro Ser Val  Ser Ser Asn 
    2420                 2425                 2430             


Thr Tyr  Ser Leu Asp Gly Gly  Ser Asn Val Gly Gly  Thr Pro Ser 
    2435                 2440                 2445             


Thr Leu  Pro Pro Phe Thr Ile  Thr His Pro Val Glu  Thr Ser Ser 
    2450                 2455                 2460             


Ala Leu  Leu Ala Trp Ser Arg  Pro Val Arg Thr Phe  Ser Thr Met 
    2465                 2470                 2475             


Val Ser  Thr Asp Thr Ala Ser  Gly Glu Asn Pro Thr  Ser Ser Asn 
    2480                 2485                 2490             


Ser Val  Val Thr Ser Val Pro  Ala Pro Gly Thr Trp  Ala Ser Val 
    2495                 2500                 2505             


Gly Ser  Thr Thr Asp Leu Pro  Ala Met Gly Phe Leu  Lys Thr Ser 
    2510                 2515                 2520             


Pro Ala  Gly Glu Ala His Ser  Leu Leu Ala Ser Thr  Ile Glu Pro 
    2525                 2530                 2535             


Ala Thr  Ala Phe Thr Pro His  Leu Ser Ala Ala Val  Val Thr Gly 
    2540                 2545                 2550             


Ser Ser  Ala Thr Ser Glu Ala  Ser Leu Leu Thr Thr  Ser Glu Ser 
    2555                 2560                 2565             


Lys Ala  Ile His Ser Ser Pro  Gln Thr Pro Thr Thr  Pro Thr Ser 
    2570                 2575                 2580             


Gly Ala  Asn Trp Glu Thr Ser  Ala Thr Pro Glu Ser  Leu Leu Val 
    2585                 2590                 2595             


Val Thr  Glu Thr Ser Asp Thr  Thr Leu Thr Ser Lys  Ile Leu Val 
    2600                 2605                 2610             


Thr Asp  Thr Ile Leu Phe Ser  Thr Val Ser Thr Pro  Pro Ser Lys 
    2615                 2620                 2625             


Phe Pro  Ser Thr Gly Thr Leu  Ser Gly Ala Ser Phe  Pro Thr Leu 
    2630                 2635                 2640             


Leu Pro  Asp Thr Pro Ala Ile  Pro Leu Thr Ala Thr  Glu Pro Thr 
    2645                 2650                 2655             


Ser Ser  Leu Ala Thr Ser Phe  Asp Ser Thr Pro Leu  Val Thr Ile 
    2660                 2665                 2670             


Ala Ser  Asp Ser Leu Gly Thr  Val Pro Glu Thr Thr  Leu Thr Met 
    2675                 2680                 2685             


Ser Glu  Thr Ser Asn Gly Asp  Ala Leu Val Leu Lys  Thr Val Ser 
    2690                 2695                 2700             


Asn Pro  Asp Arg Ser Ile Pro  Gly Ile Thr Ile Gln  Gly Val Thr 
    2705                 2710                 2715             


Glu Ser  Pro Leu His Pro Ser  Ser Thr Ser Pro Ser  Lys Ile Val 
    2720                 2725                 2730             


Ala Pro  Arg Asn Thr Thr Tyr  Glu Gly Ser Ile Thr  Val Ala Leu 
    2735                 2740                 2745             


Ser Thr  Leu Pro Ala Gly Thr  Thr Gly Ser Leu Val  Phe Ser Gln 
    2750                 2755                 2760             


Ser Ser  Glu Asn Ser Glu Thr  Thr Ala Leu Val Asp  Ser Ser Ala 
    2765                 2770                 2775             


Gly Leu  Glu Arg Ala Ser Val  Met Pro Leu Thr Thr  Gly Ser Gln 
    2780                 2785                 2790             


Gly Met  Ala Ser Ser Gly Gly  Ile Arg Ser Gly Ser  Thr His Ser 
    2795                 2800                 2805             


Thr Gly  Thr Lys Thr Phe Ser  Ser Leu Pro Leu Thr  Met Asn Pro 
    2810                 2815                 2820             


Gly Glu  Val Thr Ala Met Ser  Glu Ile Thr Thr Asn  Arg Leu Thr 
    2825                 2830                 2835             


Ala Thr  Gln Ser Thr Ala Pro  Lys Gly Ile Pro Val  Lys Pro Thr 
    2840                 2845                 2850             


Ser Ala  Glu Ser Gly Leu Leu  Thr Pro Val Ser Ala  Ser Ser Ser 
    2855                 2860                 2865             


Pro Ser  Lys Ala Phe Ala Ser  Leu Thr Thr Ala Pro  Pro Ser Thr 
    2870                 2875                 2880             


Trp Gly  Ile Pro Gln Ser Thr  Leu Thr Phe Glu Phe  Ser Glu Val 
    2885                 2890                 2895             


Pro Ser  Leu Asp Thr Lys Ser  Ala Ser Leu Pro Thr  Pro Gly Gln 
    2900                 2905                 2910             


Ser Leu  Asn Thr Ile Pro Asp  Ser Asp Ala Ser Thr  Ala Ser Ser 
    2915                 2920                 2925             


Ser Leu  Ser Lys Ser Pro Glu  Lys Asn Pro Arg Ala  Arg Met Met 
    2930                 2935                 2940             


Thr Ser  Thr Lys Ala Ile Ser  Ala Ser Ser Phe Gln  Ser Thr Gly 
    2945                 2950                 2955             


Phe Thr  Glu Thr Pro Glu Gly  Ser Ala Ser Pro Ser  Met Ala Gly 
    2960                 2965                 2970             


His Glu  Pro Arg Val Pro Thr  Ser Gly Thr Gly Asp  Pro Arg Tyr 
    2975                 2980                 2985             


Ala Ser  Glu Ser Met Ser Tyr  Pro Asp Pro Ser Lys  Ala Ser Ser 
    2990                 2995                 3000             


Ala Met  Thr Ser Thr Ser Leu  Ala Ser Lys Leu Thr  Thr Leu Phe 
    3005                 3010                 3015             


Ser Thr  Gly Gln Ala Ala Arg  Ser Gly Ser Ser Ser  Ser Pro Ile 
    3020                 3025                 3030             


Ser Leu  Ser Thr Glu Lys Glu  Thr Ser Phe Leu Ser  Pro Thr Ala 
    3035                 3040                 3045             


Ser Thr  Ser Arg Lys Thr Ser  Leu Phe Leu Gly Pro  Ser Met Ala 
    3050                 3055                 3060             


Arg Gln  Pro Asn Ile Leu Val  His Leu Gln Thr Ser  Ala Leu Thr 
    3065                 3070                 3075             


Leu Ser  Pro Thr Ser Thr Leu  Asn Met Ser Gln Glu  Glu Pro Pro 
    3080                 3085                 3090             


Glu Leu  Thr Ser Ser Gln Thr  Ile Ala Glu Glu Glu  Gly Thr Thr 
    3095                 3100                 3105             


Ala Glu  Thr Gln Thr Leu Thr  Phe Thr Pro Ser Glu  Thr Pro Thr 
    3110                 3115                 3120             


Ser Leu  Leu Pro Val Ser Ser  Pro Thr Glu Pro Thr  Ala Arg Arg 
    3125                 3130                 3135             


Lys Ser  Ser Pro Glu Thr Trp  Ala Ser Ser Ile Ser  Val Pro Ala 
    3140                 3145                 3150             


Lys Thr  Ser Leu Val Glu Thr  Thr Asp Gly Thr Leu  Val Thr Thr 
    3155                 3160                 3165             


Ile Lys  Met Ser Ser Gln Ala  Ala Gln Gly Asn Ser  Thr Trp Pro 
    3170                 3175                 3180             


Ala Pro  Ala Glu Glu Thr Gly  Thr Ser Pro Ala Gly  Thr Ser Pro 
    3185                 3190                 3195             


Gly Ser  Pro Glu Val Ser Thr  Thr Leu Lys Ile Met  Ser Ser Lys 
    3200                 3205                 3210             


Glu Pro  Ser Ile Ser Pro Glu  Ile Arg Ser Thr Val  Arg Asn Ser 
    3215                 3220                 3225             


Pro Trp  Lys Thr Pro Glu Thr  Thr Val Pro Met Glu  Thr Thr Val 
    3230                 3235                 3240             


Glu Pro  Val Thr Leu Gln Ser  Thr Ala Leu Gly Ser  Gly Ser Thr 
    3245                 3250                 3255             


Ser Ile  Ser His Leu Pro Thr  Gly Thr Thr Ser Pro  Thr Lys Ser 
    3260                 3265                 3270             


Pro Thr  Glu Asn Met Leu Ala  Thr Glu Arg Val Ser  Leu Ser Pro 
    3275                 3280                 3285             


Ser Pro  Pro Glu Ala Trp Thr  Asn Leu Tyr Ser Gly  Thr Pro Gly 
    3290                 3295                 3300             


Gly Thr  Arg Gln Ser Leu Ala  Thr Met Ser Ser Val  Ser Leu Glu 
    3305                 3310                 3315             


Ser Pro  Thr Ala Arg Ser Ile  Thr Gly Thr Gly Gln  Gln Ser Ser 
    3320                 3325                 3330             


Pro Glu  Leu Val Ser Lys Thr  Thr Gly Met Glu Phe  Ser Met Trp 
    3335                 3340                 3345             


His Gly  Ser Thr Gly Gly Thr  Thr Gly Asp Thr His  Val Ser Leu 
    3350                 3355                 3360             


Ser Thr  Ser Ser Asn Ile Leu  Glu Asp Pro Val Thr  Ser Pro Asn 
    3365                 3370                 3375             


Ser Val  Ser Ser Leu Thr Asp  Lys Ser Lys His Lys  Thr Glu Thr 
    3380                 3385                 3390             


Trp Val  Ser Thr Thr Ala Ile  Pro Ser Thr Val Leu  Asn Asn Lys 
    3395                 3400                 3405             


Ile Met  Ala Ala Glu Gln Gln  Thr Ser Arg Ser Val  Asp Glu Ala 
    3410                 3415                 3420             


Tyr Ser  Ser Thr Ser Ser Trp  Ser Asp Gln Thr Ser  Gly Ser Asp 
    3425                 3430                 3435             


Ile Thr  Leu Gly Ala Ser Pro  Asp Val Thr Asn Thr  Leu Tyr Ile 
    3440                 3445                 3450             


Thr Ser  Thr Ala Gln Thr Thr  Ser Leu Val Ser Leu  Pro Ser Gly 
    3455                 3460                 3465             


Asp Gln  Gly Ile Thr Ser Leu  Thr Asn Pro Ser Gly  Gly Lys Thr 
    3470                 3475                 3480             


Ser Ser  Ala Ser Ser Val Thr  Ser Pro Ser Ile Gly  Leu Glu Thr 
    3485                 3490                 3495             


Leu Arg  Ala Asn Val Ser Ala  Val Lys Ser Asp Ile  Ala Pro Thr 
    3500                 3505                 3510             


Ala Gly  His Leu Ser Gln Thr  Ser Ser Pro Ala Glu  Val Ser Ile 
    3515                 3520                 3525             


Leu Asp  Val Thr Thr Ala Pro  Thr Pro Gly Ile Ser  Thr Thr Ile 
    3530                 3535                 3540             


Thr Thr  Met Gly Thr Asn Ser  Ile Ser Thr Thr Thr  Pro Asn Pro 
    3545                 3550                 3555             


Glu Val  Gly Met Ser Thr Met  Asp Ser Thr Pro Ala  Thr Glu Arg 
    3560                 3565                 3570             


Arg Thr  Thr Ser Thr Glu His  Pro Ser Thr Trp Ser  Ser Thr Ala 
    3575                 3580                 3585             


Ala Ser  Asp Ser Trp Thr Val  Thr Asp Met Thr Ser  Asn Leu Lys 
    3590                 3595                 3600             


Val Ala  Arg Ser Pro Gly Thr  Ile Ser Thr Met His  Thr Thr Ser 
    3605                 3610                 3615             


Phe Leu  Ala Ser Ser Thr Glu  Leu Asp Ser Met Ser  Thr Pro His 
    3620                 3625                 3630             


Gly Arg  Ile Thr Val Ile Gly  Thr Ser Leu Val Thr  Pro Ser Ser 
    3635                 3640                 3645             


Asp Ala  Ser Ala Val Lys Thr  Glu Thr Ser Thr Ser  Glu Arg Thr 
    3650                 3655                 3660             


Leu Ser  Pro Ser Asp Thr Thr  Ala Ser Thr Pro Ile  Ser Thr Phe 
    3665                 3670                 3675             


Ser Arg  Val Gln Arg Met Ser  Ile Ser Val Pro Asp  Ile Leu Ser 
    3680                 3685                 3690             


Thr Ser  Trp Thr Pro Ser Ser  Thr Glu Ala Glu Asp  Val Pro Val 
    3695                 3700                 3705             


Ser Met  Val Ser Thr Asp His  Ala Ser Thr Lys Thr  Asp Pro Asn 
    3710                 3715                 3720             


Thr Pro  Leu Ser Thr Phe Leu  Phe Asp Ser Leu Ser  Thr Leu Asp 
    3725                 3730                 3735             


Trp Asp  Thr Gly Arg Ser Leu  Ser Ser Ala Thr Ala  Thr Thr Ser 
    3740                 3745                 3750             


Ala Pro  Gln Gly Ala Thr Thr  Pro Gln Glu Leu Thr  Leu Glu Thr 
    3755                 3760                 3765             


Met Ile  Ser Pro Ala Thr Ser  Gln Leu Pro Phe Ser  Ile Gly His 
    3770                 3775                 3780             


Ile Thr  Ser Ala Val Thr Pro  Ala Ala Met Ala Arg  Ser Ser Gly 
    3785                 3790                 3795             


Val Thr  Phe Ser Arg Pro Asp  Pro Thr Ser Lys Lys  Ala Glu Gln 
    3800                 3805                 3810             


Thr Ser  Thr Gln Leu Pro Thr  Thr Thr Ser Ala His  Pro Gly Gln 
    3815                 3820                 3825             


Val Pro  Arg Ser Ala Ala Thr  Thr Leu Asp Val Ile  Pro His Thr 
    3830                 3835                 3840             


Ala Lys  Thr Pro Asp Ala Thr  Phe Gln Arg Gln Gly  Gln Thr Ala 
    3845                 3850                 3855             


Leu Thr  Thr Glu Ala Arg Ala  Thr Ser Asp Ser Trp  Asn Glu Lys 
    3860                 3865                 3870             


Glu Lys  Ser Thr Pro Ser Ala  Pro Trp Ile Thr Glu  Met Met Asn 
    3875                 3880                 3885             


Ser Val  Ser Glu Asp Thr Ile  Lys Glu Val Thr Ser  Ser Ser Ser 
    3890                 3895                 3900             


Val Leu  Lys Asp Pro Glu Tyr  Ala Gly His Lys Leu  Gly Ile Trp 
    3905                 3910                 3915             


Asp Asp  Phe Ile Pro Lys Phe  Gly Lys Ala Ala His  Met Arg Glu 
    3920                 3925                 3930             


Leu Pro  Leu Leu Ser Pro Pro  Gln Asp Lys Glu Ala  Ile His Pro 
    3935                 3940                 3945             


Ser Thr  Asn Thr Val Glu Thr  Thr Gly Trp Val Thr  Ser Ser Glu 
    3950                 3955                 3960             


His Ala  Ser His Ser Thr Ile  Pro Ala His Ser Ala  Ser Ser Lys 
    3965                 3970                 3975             


Leu Thr  Ser Pro Val Val Thr  Thr Ser Thr Arg Glu  Gln Ala Ile 
    3980                 3985                 3990             


Val Ser  Met Ser Thr Thr Thr  Trp Pro Glu Ser Thr  Arg Ala Arg 
    3995                 4000                 4005             


Thr Glu  Pro Asn Ser Phe Leu  Thr Ile Glu Leu Arg  Asp Val Ser 
    4010                 4015                 4020             


Pro Tyr  Met Asp Thr Ser Ser  Thr Thr Gln Thr Ser  Ile Ile Ser 
    4025                 4030                 4035             


Ser Pro  Gly Ser Thr Ala Ile  Thr Lys Gly Pro Arg  Thr Glu Ile 
    4040                 4045                 4050             


Thr Ser  Ser Lys Arg Ile Ser  Ser Ser Phe Leu Ala  Gln Ser Met 
    4055                 4060                 4065             


Arg Ser  Ser Asp Ser Pro Ser  Glu Ala Ile Thr Arg  Leu Ser Asn 
    4070                 4075                 4080             


Phe Pro  Ala Met Thr Glu Ser  Gly Gly Met Ile Leu  Ala Met Gln 
    4085                 4090                 4095             


Thr Ser  Pro Pro Gly Ala Thr  Ser Leu Ser Ala Pro  Thr Leu Asp 
    4100                 4105                 4110             


Thr Ser  Ala Thr Ala Ser Trp  Thr Gly Thr Pro Leu  Ala Thr Thr 
    4115                 4120                 4125             


Gln Arg  Phe Thr Tyr Ser Glu  Lys Thr Thr Leu Phe  Ser Lys Gly 
    4130                 4135                 4140             


Pro Glu  Asp Thr Ser Gln Pro  Ser Pro Pro Ser Val  Glu Glu Thr 
    4145                 4150                 4155             


Ser Ser  Ser Ser Ser Leu Val  Pro Ile His Ala Thr  Thr Ser Pro 
    4160                 4165                 4170             


Ser Asn  Ile Leu Leu Thr Ser  Gln Gly His Ser Pro  Ser Ser Thr 
    4175                 4180                 4185             


Pro Pro  Val Thr Ser Val Phe  Leu Ser Glu Thr Ser  Gly Leu Gly 
    4190                 4195                 4200             


Lys Thr  Thr Asp Met Ser Arg  Ile Ser Leu Glu Pro  Gly Thr Ser 
    4205                 4210                 4215             


Leu Pro  Pro Asn Leu Ser Ser  Thr Ala Gly Glu Ala  Leu Ser Thr 
    4220                 4225                 4230             


Tyr Glu  Ala Ser Arg Asp Thr  Lys Ala Ile His His  Ser Ala Asp 
    4235                 4240                 4245             


Thr Ala  Val Thr Asn Met Glu  Ala Thr Ser Ser Glu  Tyr Ser Pro 
    4250                 4255                 4260             


Ile Pro  Gly His Thr Lys Pro  Ser Lys Ala Thr Ser  Pro Leu Val 
    4265                 4270                 4275             


Thr Ser  His Ile Met Gly Asp  Ile Thr Ser Ser Thr  Ser Val Phe 
    4280                 4285                 4290             


Gly Ser  Ser Glu Thr Thr Glu  Ile Glu Thr Val Ser  Ser Val Asn 
    4295                 4300                 4305             


Gln Gly  Leu Gln Glu Arg Ser  Thr Ser Gln Val Ala  Ser Ser Ala 
    4310                 4315                 4320             


Thr Glu  Thr Ser Thr Val Ile  Thr His Val Ser Ser  Gly Asp Ala 
    4325                 4330                 4335             


Thr Thr  His Val Thr Lys Thr  Gln Ala Thr Phe Ser  Ser Gly Thr 
    4340                 4345                 4350             


Ser Ile  Ser Ser Pro His Gln  Phe Ile Thr Ser Thr  Asn Thr Phe 
    4355                 4360                 4365             


Thr Asp  Val Ser Thr Asn Pro  Ser Thr Ser Leu Ile  Met Thr Glu 
    4370                 4375                 4380             


Ser Ser  Gly Val Thr Ile Thr  Thr Gln Thr Gly Pro  Thr Gly Ala 
    4385                 4390                 4395             


Ala Thr  Gln Gly Pro Tyr Leu  Leu Asp Thr Ser Thr  Met Pro Tyr 
    4400                 4405                 4410             


Leu Thr  Glu Thr Pro Leu Ala  Val Thr Pro Asp Phe  Met Gln Ser 
    4415                 4420                 4425             


Glu Lys  Thr Thr Leu Ile Ser  Lys Gly Pro Lys Asp  Val Thr Trp 
    4430                 4435                 4440             


Thr Ser  Pro Pro Ser Val Ala  Glu Thr Ser Tyr Pro  Ser Ser Leu 
    4445                 4450                 4455             


Thr Pro  Phe Leu Val Thr Thr  Ile Pro Pro Ala Thr  Ser Thr Leu 
    4460                 4465                 4470             


Gln Gly  Gln His Thr Ser Ser  Pro Val Ser Ala Thr  Ser Val Leu 
    4475                 4480                 4485             


Thr Ser  Gly Leu Val Lys Thr  Thr Asp Met Leu Asn  Thr Ser Met 
    4490                 4495                 4500             


Glu Pro  Val Thr Asn Ser Pro  Gln Asn Leu Asn Asn  Pro Ser Asn 
    4505                 4510                 4515             


Glu Ile  Leu Ala Thr Leu Ala  Ala Thr Thr Asp Ile  Glu Thr Ile 
    4520                 4525                 4530             


His Pro  Ser Ile Asn Lys Ala  Val Thr Asn Met Gly  Thr Ala Ser 
    4535                 4540                 4545             


Ser Ala  His Val Leu His Ser  Thr Leu Pro Val Ser  Ser Glu Pro 
    4550                 4555                 4560             


Ser Thr  Ala Thr Ser Pro Met  Val Pro Ala Ser Ser  Met Gly Asp 
    4565                 4570                 4575             


Ala Leu  Ala Ser Ile Ser Ile  Pro Gly Ser Glu Thr  Thr Asp Ile 
    4580                 4585                 4590             


Glu Gly  Glu Pro Thr Ser Ser  Leu Thr Ala Gly Arg  Lys Glu Asn 
    4595                 4600                 4605             


Ser Thr  Leu Gln Glu Met Asn  Ser Thr Thr Glu Ser  Asn Ile Ile 
    4610                 4615                 4620             


Leu Ser  Asn Val Ser Val Gly  Ala Ile Thr Glu Ala  Thr Lys Met 
    4625                 4630                 4635             


Glu Val  Pro Ser Phe Asp Ala  Thr Phe Ile Pro Thr  Pro Ala Gln 
    4640                 4645                 4650             


Ser Thr  Lys Phe Pro Asp Ile  Phe Ser Val Ala Ser  Ser Arg Leu 
    4655                 4660                 4665             


Ser Asn  Ser Pro Pro Met Thr  Ile Ser Thr His Met  Thr Thr Thr 
    4670                 4675                 4680             


Gln Thr  Gly Ser Ser Gly Ala  Thr Ser Lys Ile Pro  Leu Ala Leu 
    4685                 4690                 4695             


Asp Thr  Ser Thr Leu Glu Thr  Ser Ala Gly Thr Pro  Ser Val Val 
    4700                 4705                 4710             


Thr Glu  Gly Phe Ala His Ser  Lys Ile Thr Thr Ala  Met Asn Asn 
    4715                 4720                 4725             


Asp Val  Lys Asp Val Ser Gln  Thr Asn Pro Pro Phe  Gln Asp Glu 
    4730                 4735                 4740             


Ala Ser  Ser Pro Ser Ser Gln  Ala Pro Val Leu Val  Thr Thr Leu 
    4745                 4750                 4755             


Pro Ser  Ser Val Ala Phe Thr  Pro Gln Trp His Ser  Thr Ser Ser 
    4760                 4765                 4770             


Pro Val  Ser Met Ser Ser Val  Leu Thr Ser Ser Leu  Val Lys Thr 
    4775                 4780                 4785             


Ala Gly  Lys Val Asp Thr Ser  Leu Glu Thr Val Thr  Ser Ser Pro 
    4790                 4795                 4800             


Gln Ser  Met Ser Asn Thr Leu  Asp Asp Ile Ser Val  Thr Ser Ala 
    4805                 4810                 4815             


Ala Thr  Thr Asp Ile Glu Thr  Thr His Pro Ser Ile  Asn Thr Val 
    4820                 4825                 4830             


Val Thr  Asn Val Gly Thr Thr  Gly Ser Ala Phe Glu  Ser His Ser 
    4835                 4840                 4845             


Thr Val  Ser Ala Tyr Pro Glu  Pro Ser Lys Val Thr  Ser Pro Asn 
    4850                 4855                 4860             


Val Thr  Thr Ser Thr Met Glu  Asp Thr Thr Ile Ser  Arg Ser Ile 
    4865                 4870                 4875             


Pro Lys  Ser Ser Lys Thr Thr  Arg Thr Glu Thr Glu  Thr Thr Ser 
    4880                 4885                 4890             


Ser Leu  Thr Pro Lys Leu Arg  Glu Thr Ser Ile Ser  Gln Glu Ile 
    4895                 4900                 4905             


Thr Ser  Ser Thr Glu Thr Ser  Thr Val Pro Tyr Lys  Glu Leu Thr 
    4910                 4915                 4920             


Gly Ala  Thr Thr Glu Val Ser  Arg Thr Asp Val Thr  Ser Ser Ser 
    4925                 4930                 4935             


Ser Thr  Ser Phe Pro Gly Pro  Asp Gln Ser Thr Val  Ser Leu Asp 
    4940                 4945                 4950             


Ile Ser  Thr Glu Thr Asn Thr  Arg Leu Ser Thr Ser  Pro Ile Met 
    4955                 4960                 4965             


Thr Glu  Ser Ala Glu Ile Thr  Ile Thr Thr Gln Thr  Gly Pro His 
    4970                 4975                 4980             


Gly Ala  Thr Ser Gln Asp Thr  Phe Thr Met Asp Pro  Ser Asn Thr 
    4985                 4990                 4995             


Thr Pro  Gln Ala Gly Ile His  Ser Ala Met Thr His  Gly Phe Ser 
    5000                 5005                 5010             


Gln Leu  Asp Val Thr Thr Leu  Met Ser Arg Ile Pro  Gln Asp Val 
    5015                 5020                 5025             


Ser Trp  Thr Ser Pro Pro Ser  Val Asp Lys Thr Ser  Ser Pro Ser 
    5030                 5035                 5040             


Ser Phe  Leu Ser Ser Pro Ala  Met Thr Thr Pro Ser  Leu Ile Ser 
    5045                 5050                 5055             


Ser Thr  Leu Pro Glu Asp Lys  Leu Ser Ser Pro Met  Thr Ser Leu 
    5060                 5065                 5070             


Leu Thr  Ser Gly Leu Val Lys  Ile Thr Asp Ile Leu  Arg Thr Arg 
    5075                 5080                 5085             


Leu Glu  Pro Val Thr Ser Ser  Leu Pro Asn Phe Ser  Ser Thr Ser 
    5090                 5095                 5100             


Asp Lys  Ile Leu Ala Thr Ser  Lys Asp Ser Lys Asp  Thr Lys Glu 
    5105                 5110                 5115             


Ile Phe  Pro Ser Ile Asn Thr  Glu Glu Thr Asn Val  Lys Ala Asn 
    5120                 5125                 5130             


Asn Ser  Gly His Glu Ser His  Ser Pro Ala Leu Ala  Asp Ser Glu 
    5135                 5140                 5145             


Thr Pro  Lys Ala Thr Thr Gln  Met Val Ile Thr Thr  Thr Val Gly 
    5150                 5155                 5160             


Asp Pro  Ala Pro Ser Thr Ser  Met Pro Val His Gly  Ser Ser Glu 
    5165                 5170                 5175             


Thr Thr  Asn Ile Lys Arg Glu  Pro Thr Tyr Phe Leu  Thr Pro Arg 
    5180                 5185                 5190             


Leu Arg  Glu Thr Ser Thr Ser  Gln Glu Ser Ser Phe  Pro Thr Asp 
    5195                 5200                 5205             


Thr Ser  Phe Leu Leu Ser Lys  Val Pro Thr Gly Thr  Ile Thr Glu 
    5210                 5215                 5220             


Val Ser  Ser Thr Gly Val Asn  Ser Ser Ser Lys Ile  Ser Thr Pro 
    5225                 5230                 5235             


Asp His  Asp Lys Ser Thr Val  Pro Pro Asp Thr Phe  Thr Gly Glu 
    5240                 5245                 5250             


Ile Pro  Arg Val Phe Thr Ser  Ser Ile Lys Thr Lys  Ser Ala Glu 
    5255                 5260                 5265             


Met Thr  Ile Thr Thr Gln Ala  Ser Pro Pro Glu Ser  Ala Ser His 
    5270                 5275                 5280             


Ser Thr  Leu Pro Leu Asp Thr  Ser Thr Thr Leu Ser  Gln Gly Gly 
    5285                 5290                 5295             


Thr His  Ser Thr Val Thr Gln  Gly Phe Pro Tyr Ser  Glu Val Thr 
    5300                 5305                 5310             


Thr Leu  Met Gly Met Gly Pro  Gly Asn Val Ser Trp  Met Thr Thr 
    5315                 5320                 5325             


Pro Pro  Val Glu Glu Thr Ser  Ser Val Ser Ser Leu  Met Ser Ser 
    5330                 5335                 5340             


Pro Ala  Met Thr Ser Pro Ser  Pro Val Ser Ser Thr  Ser Pro Gln 
    5345                 5350                 5355             


Ser Ile  Pro Ser Ser Pro Leu  Pro Val Thr Ala Leu  Pro Thr Ser 
    5360                 5365                 5370             


Val Leu  Val Thr Thr Thr Asp  Val Leu Gly Thr Thr  Ser Pro Glu 
    5375                 5380                 5385             


Ser Val  Thr Ser Ser Pro Pro  Asn Leu Ser Ser Ile  Thr His Glu 
    5390                 5395                 5400             


Arg Pro  Ala Thr Tyr Lys Asp  Thr Ala His Thr Glu  Ala Ala Met 
    5405                 5410                 5415             


His His  Ser Thr Asn Thr Ala  Val Thr Asn Val Gly  Thr Ser Gly 
    5420                 5425                 5430             


Ser Gly  His Lys Ser Gln Ser  Ser Val Leu Ala Asp  Ser Glu Thr 
    5435                 5440                 5445             


Ser Lys  Ala Thr Pro Leu Met  Ser Thr Thr Ser Thr  Leu Gly Asp 
    5450                 5455                 5460             


Thr Ser  Val Ser Thr Ser Thr  Pro Asn Ile Ser Gln  Thr Asn Gln 
    5465                 5470                 5475             


Ile Gln  Thr Glu Pro Thr Ala  Ser Leu Ser Pro Arg  Leu Arg Glu 
    5480                 5485                 5490             


Ser Ser  Thr Ser Glu Lys Thr  Ser Ser Thr Thr Glu  Thr Asn Thr 
    5495                 5500                 5505             


Ala Phe  Ser Tyr Val Pro Thr  Gly Ala Ile Thr Gln  Ala Ser Arg 
    5510                 5515                 5520             


Thr Glu  Ile Ser Ser Ser Arg  Thr Ser Ile Ser Asp  Leu Asp Arg 
    5525                 5530                 5535             


Pro Thr  Ile Ala Pro Asp Ile  Ser Thr Gly Met Ile  Thr Arg Leu 
    5540                 5545                 5550             


Phe Thr  Ser Pro Ile Met Thr  Lys Ser Ala Glu Met  Thr Val Thr 
    5555                 5560                 5565             


Thr Gln  Thr Thr Thr Pro Gly  Ala Thr Ser Gln Gly  Ile Leu Pro 
    5570                 5575                 5580             


Trp Asp  Thr Ser Thr Thr Leu  Phe Gln Gly Gly Thr  His Ser Thr 
    5585                 5590                 5595             


Val Ser  Gln Gly Phe Pro His  Ser Glu Ile Thr Thr  Leu Arg Ser 
    5600                 5605                 5610             


Arg Thr  Pro Gly Asp Val Ser  Trp Met Thr Thr Pro  Pro Val Glu 
    5615                 5620                 5625             


Glu Thr  Ser Ser Gly Phe Ser  Leu Met Ser Pro Ser  Met Thr Ser 
    5630                 5635                 5640             


Pro Ser  Pro Val Ser Ser Thr  Ser Pro Glu Ser Ile  Pro Ser Ser 
    5645                 5650                 5655             


Pro Leu  Pro Val Thr Ala Leu  Leu Thr Ser Val Leu  Val Thr Thr 
    5660                 5665                 5670             


Thr Asn  Val Leu Gly Thr Thr  Ser Pro Glu Thr Val  Thr Ser Ser 
    5675                 5680                 5685             


Pro Pro  Asn Leu Ser Ser Pro  Thr Gln Glu Arg Leu  Thr Thr Tyr 
    5690                 5695                 5700             


Lys Asp  Thr Ala His Thr Glu  Ala Met His Ala Ser  Met His Thr 
    5705                 5710                 5715             


Asn Thr  Ala Val Ala Asn Val  Gly Thr Ser Ile Ser  Gly His Glu 
    5720                 5725                 5730             


Ser Gln  Ser Ser Val Pro Ala  Asp Ser His Thr Ser  Lys Ala Thr 
    5735                 5740                 5745             


Ser Pro  Met Gly Ile Thr Phe  Ala Met Gly Asp Thr  Ser Val Ser 
    5750                 5755                 5760             


Thr Ser  Thr Pro Ala Phe Phe  Glu Thr Arg Ile Gln  Thr Glu Ser 
    5765                 5770                 5775             


Thr Ser  Ser Leu Ile Pro Gly  Leu Arg Asp Thr Arg  Thr Ser Glu 
    5780                 5785                 5790             


Glu Ile  Asn Thr Val Thr Glu  Thr Ser Thr Val Leu  Ser Glu Val 
    5795                 5800                 5805             


Pro Thr  Thr Thr Thr Thr Glu  Val Ser Arg Thr Glu  Val Ile Thr 
    5810                 5815                 5820             


Ser Ser  Arg Thr Thr Ile Ser  Gly Pro Asp His Ser  Lys Met Ser 
    5825                 5830                 5835             


Pro Tyr  Ile Ser Thr Glu Thr  Ile Thr Arg Leu Ser  Thr Phe Pro 
    5840                 5845                 5850             


Phe Val  Thr Gly Ser Thr Glu  Met Ala Ile Thr Asn  Gln Thr Gly 
    5855                 5860                 5865             


Pro Ile  Gly Thr Ile Ser Gln  Ala Thr Leu Thr Leu  Asp Thr Ser 
    5870                 5875                 5880             


Ser Thr  Ala Ser Trp Glu Gly  Thr His Ser Pro Val  Thr Gln Arg 
    5885                 5890                 5895             


Phe Pro  His Ser Glu Glu Thr  Thr Thr Met Ser Arg  Ser Thr Lys 
    5900                 5905                 5910             


Gly Val  Ser Trp Gln Ser Pro  Pro Ser Val Glu Glu  Thr Ser Ser 
    5915                 5920                 5925             


Pro Ser  Ser Pro Val Pro Leu  Pro Ala Ile Thr Ser  His Ser Ser 
    5930                 5935                 5940             


Leu Tyr  Ser Ala Val Ser Gly  Ser Ser Pro Thr Ser  Ala Leu Pro 
    5945                 5950                 5955             


Val Thr  Ser Leu Leu Thr Ser  Gly Arg Arg Lys Thr  Ile Asp Met 
    5960                 5965                 5970             


Leu Asp  Thr His Ser Glu Leu  Val Thr Ser Ser Leu  Pro Ser Ala 
    5975                 5980                 5985             


Ser Ser  Phe Ser Gly Glu Ile  Leu Thr Ser Glu Ala  Ser Thr Asn 
    5990                 5995                 6000             


Thr Glu  Thr Ile His Phe Ser  Glu Asn Thr Ala Glu  Thr Asn Met 
    6005                 6010                 6015             


Gly Thr  Thr Asn Ser Met His  Lys Leu His Ser Ser  Val Ser Ile 
    6020                 6025                 6030             


His Ser  Gln Pro Ser Gly His  Thr Pro Pro Lys Val  Thr Gly Ser 
    6035                 6040                 6045             


Met Met  Glu Asp Ala Ile Val  Ser Thr Ser Thr Pro  Gly Ser Pro 
    6050                 6055                 6060             


Glu Thr  Lys Asn Val Asp Arg  Asp Ser Thr Ser Pro  Leu Thr Pro 
    6065                 6070                 6075             


Glu Leu  Lys Glu Asp Ser Thr  Ala Leu Val Met Asn  Ser Thr Thr 
    6080                 6085                 6090             


Glu Ser  Asn Thr Val Phe Ser  Ser Val Ser Leu Asp  Ala Ala Thr 
    6095                 6100                 6105             


Glu Val  Ser Arg Ala Glu Val  Thr Tyr Tyr Asp Pro  Thr Phe Met 
    6110                 6115                 6120             


Pro Ala  Ser Ala Gln Ser Thr  Lys Ser Pro Asp Ile  Ser Pro Glu 
    6125                 6130                 6135             


Ala Ser  Ser Ser His Ser Asn  Ser Pro Pro Leu Thr  Ile Ser Thr 
    6140                 6145                 6150             


His Lys  Thr Ile Ala Thr Gln  Thr Gly Pro Ser Gly  Val Thr Ser 
    6155                 6160                 6165             


Leu Gly  Gln Leu Thr Leu Asp  Thr Ser Thr Ile Ala  Thr Ser Ala 
    6170                 6175                 6180             


Gly Thr  Pro Ser Ala Arg Thr  Gln Asp Phe Val Asp  Ser Glu Thr 
    6185                 6190                 6195             


Thr Ser  Val Met Asn Asn Asp  Leu Asn Asp Val Leu  Lys Thr Ser 
    6200                 6205                 6210             


Pro Phe  Ser Ala Glu Glu Ala  Asn Ser Leu Ser Ser  Gln Ala Pro 
    6215                 6220                 6225             


Leu Leu  Val Thr Thr Ser Pro  Ser Pro Val Thr Ser  Thr Leu Gln 
    6230                 6235                 6240             


Glu His  Ser Thr Ser Ser Leu  Val Ser Val Thr Ser  Val Pro Thr 
    6245                 6250                 6255             


Pro Thr  Leu Ala Lys Ile Thr  Asp Met Asp Thr Asn  Leu Glu Pro 
    6260                 6265                 6270             


Val Thr  Arg Ser Pro Gln Asn  Leu Arg Asn Thr Leu  Ala Thr Ser 
    6275                 6280                 6285             


Glu Ala  Thr Thr Asp Thr His  Thr Met His Pro Ser  Ile Asn Thr 
    6290                 6295                 6300             


Ala Met  Ala Asn Val Gly Thr  Thr Ser Ser Pro Asn  Glu Phe Tyr 
    6305                 6310                 6315             


Phe Thr  Val Ser Pro Asp Ser  Asp Pro Tyr Lys Ala  Thr Ser Ala 
    6320                 6325                 6330             


Val Val  Ile Thr Ser Thr Ser  Gly Asp Ser Ile Val  Ser Thr Ser 
    6335                 6340                 6345             


Met Pro  Arg Ser Ser Ala Met  Lys Lys Ile Glu Ser  Glu Thr Thr 
    6350                 6355                 6360             


Phe Ser  Leu Ile Phe Arg Leu  Arg Glu Thr Ser Thr  Ser Gln Lys 
    6365                 6370                 6375             


Ile Gly  Ser Ser Ser Asp Thr  Ser Thr Val Phe Asp  Lys Ala Phe 
    6380                 6385                 6390             


Thr Ala  Ala Thr Thr Glu Val  Ser Arg Thr Glu Leu  Thr Ser Ser 
    6395                 6400                 6405             


Ser Arg  Thr Ser Ile Gln Gly  Thr Glu Lys Pro Thr  Met Ser Pro 
    6410                 6415                 6420             


Asp Thr  Ser Thr Arg Ser Val  Thr Met Leu Ser Thr  Phe Ala Gly 
    6425                 6430                 6435             


Leu Thr  Lys Ser Glu Glu Arg  Thr Ile Ala Thr Gln  Thr Gly Pro 
    6440                 6445                 6450             


His Arg  Ala Thr Ser Gln Gly  Thr Leu Thr Trp Asp  Thr Ser Ile 
    6455                 6460                 6465             


Thr Thr  Ser Gln Ala Gly Thr  His Ser Ala Met Thr  His Gly Phe 
    6470                 6475                 6480             


Ser Gln  Leu Asp Leu Ser Thr  Leu Thr Ser Arg Val  Pro Glu Tyr 
    6485                 6490                 6495             


Ile Ser  Gly Thr Ser Pro Pro  Ser Val Glu Lys Thr  Ser Ser Ser 
    6500                 6505                 6510             


Ser Ser  Leu Leu Ser Leu Pro  Ala Ile Thr Ser Pro  Ser Pro Val 
    6515                 6520                 6525             


Pro Thr  Thr Leu Pro Glu Ser  Arg Pro Ser Ser Pro  Val His Leu 
    6530                 6535                 6540             


Thr Ser  Leu Pro Thr Ser Gly  Leu Val Lys Thr Thr  Asp Met Leu 
    6545                 6550                 6555             


Ala Ser  Val Ala Ser Leu Pro  Pro Asn Leu Gly Ser  Thr Ser His 
    6560                 6565                 6570             


Lys Ile  Pro Thr Thr Ser Glu  Asp Ile Lys Asp Thr  Glu Lys Met 
    6575                 6580                 6585             


Tyr Pro  Ser Thr Asn Ile Ala  Val Thr Asn Val Gly  Thr Thr Thr 
    6590                 6595                 6600             


Ser Glu  Lys Glu Ser Tyr Ser  Ser Val Pro Ala Tyr  Ser Glu Pro 
    6605                 6610                 6615             


Pro Lys  Val Thr Ser Pro Met  Val Thr Ser Phe Asn  Ile Arg Asp 
    6620                 6625                 6630             


Thr Ile  Val Ser Thr Ser Met  Pro Gly Ser Ser Glu  Ile Thr Arg 
    6635                 6640                 6645             


Ile Glu  Met Glu Ser Thr Phe  Ser Val Ala His Gly  Leu Lys Gly 
    6650                 6655                 6660             


Thr Ser  Thr Ser Gln Asp Pro  Ile Val Ser Thr Glu  Lys Ser Ala 
    6665                 6670                 6675             


Val Leu  His Lys Leu Thr Thr  Gly Ala Thr Glu Thr  Ser Arg Thr 
    6680                 6685                 6690             


Glu Val  Ala Ser Ser Arg Arg  Thr Ser Ile Pro Gly  Pro Asp His 
    6695                 6700                 6705             


Ser Thr  Glu Ser Pro Asp Ile  Ser Thr Glu Val Ile  Pro Ser Leu 
    6710                 6715                 6720             


Pro Ile  Ser Leu Gly Ile Thr  Glu Ser Ser Asn Met  Thr Ile Ile 
    6725                 6730                 6735             


Thr Arg  Thr Gly Pro Pro Leu  Gly Ser Thr Ser Gln  Gly Thr Phe 
    6740                 6745                 6750             


Thr Leu  Asp Thr Pro Thr Thr  Ser Ser Arg Ala Gly  Thr His Ser 
    6755                 6760                 6765             


Met Ala  Thr Gln Glu Phe Pro  His Ser Glu Met Thr  Thr Val Met 
    6770                 6775                 6780             


Asn Lys  Asp Pro Glu Ile Leu  Ser Trp Thr Ile Pro  Pro Ser Ile 
    6785                 6790                 6795             


Glu Lys  Thr Ser Phe Ser Ser  Ser Leu Met Pro Ser  Pro Ala Met 
    6800                 6805                 6810             


Thr Ser  Pro Pro Val Ser Ser  Thr Leu Pro Lys Thr  Ile His Thr 
    6815                 6820                 6825             


Thr Pro  Ser Pro Met Thr Ser  Leu Leu Thr Pro Ser  Leu Val Met 
    6830                 6835                 6840             


Thr Thr  Asp Thr Leu Gly Thr  Ser Pro Glu Pro Thr  Thr Ser Ser 
    6845                 6850                 6855             


Pro Pro  Asn Leu Ser Ser Thr  Ser His Val Ile Leu  Thr Thr Asp 
    6860                 6865                 6870             


Glu Asp  Thr Thr Ala Ile Glu  Ala Met His Pro Ser  Thr Ser Thr 
    6875                 6880                 6885             


Ala Ala  Thr Asn Val Glu Thr  Thr Cys Ser Gly His  Gly Ser Gln 
    6890                 6895                 6900             


Ser Ser  Val Leu Thr Asp Ser  Glu Lys Thr Lys Ala  Thr Ala Pro 
    6905                 6910                 6915             


Met Asp  Thr Thr Ser Thr Met  Gly His Thr Thr Val  Ser Thr Ser 
    6920                 6925                 6930             


Met Ser  Val Ser Ser Glu Thr  Thr Lys Ile Lys Arg  Glu Ser Thr 
    6935                 6940                 6945             


Tyr Ser  Leu Thr Pro Gly Leu  Arg Glu Thr Ser Ile  Ser Gln Asn 
    6950                 6955                 6960             


Ala Ser  Phe Ser Thr Asp Thr  Ser Ile Val Leu Ser  Glu Val Pro 
    6965                 6970                 6975             


Thr Gly  Thr Thr Ala Glu Val  Ser Arg Thr Glu Val  Thr Ser Ser 
    6980                 6985                 6990             


Gly Arg  Thr Ser Ile Pro Gly  Pro Ser Gln Ser Thr  Val Leu Pro 
    6995                 7000                 7005             


Glu Ile  Ser Thr Arg Thr Met  Thr Arg Leu Phe Ala  Ser Pro Thr 
    7010                 7015                 7020             


Met Thr  Glu Ser Ala Glu Met  Thr Ile Pro Thr Gln  Thr Gly Pro 
    7025                 7030                 7035             


Ser Gly  Ser Thr Ser Gln Asp  Thr Leu Thr Leu Asp  Thr Ser Thr 
    7040                 7045                 7050             


Thr Lys  Ser Gln Ala Lys Thr  His Ser Thr Leu Thr  Gln Arg Phe 
    7055                 7060                 7065             


Pro His  Ser Glu Met Thr Thr  Leu Met Ser Arg Gly  Pro Gly Asp 
    7070                 7075                 7080             


Met Ser  Trp Gln Ser Ser Pro  Ser Leu Glu Asn Pro  Ser Ser Leu 
    7085                 7090                 7095             


Pro Ser  Leu Leu Ser Leu Pro  Ala Thr Thr Ser Pro  Pro Pro Ile 
    7100                 7105                 7110             


Ser Ser  Thr Leu Pro Val Thr  Ile Ser Ser Ser Pro  Leu Pro Val 
    7115                 7120                 7125             


Thr Ser  Leu Leu Thr Ser Ser  Pro Val Thr Thr Thr  Asp Met Leu 
    7130                 7135                 7140             


His Thr  Ser Pro Glu Leu Val  Thr Ser Ser Pro Pro  Lys Leu Ser 
    7145                 7150                 7155             


His Thr  Ser Asp Glu Arg Leu  Thr Thr Gly Lys Asp  Thr Thr Asn 
    7160                 7165                 7170             


Thr Glu  Ala Val His Pro Ser  Thr Asn Thr Ala Ala  Ser Asn Val 
    7175                 7180                 7185             


Glu Ile  Pro Ser Phe Gly His  Glu Ser Pro Ser Ser  Ala Leu Ala 
    7190                 7195                 7200             


Asp Ser  Glu Thr Ser Lys Ala  Thr Ser Pro Met Phe  Ile Thr Ser 
    7205                 7210                 7215             


Thr Gln  Glu Asp Thr Thr Val  Ala Ile Ser Thr Pro  His Phe Leu 
    7220                 7225                 7230             


Glu Thr  Ser Arg Ile Gln Lys  Glu Ser Ile Ser Ser  Leu Ser Pro 
    7235                 7240                 7245             


Lys Leu  Arg Glu Thr Gly Ser  Ser Val Glu Thr Ser  Ser Ala Ile 
    7250                 7255                 7260             


Glu Thr  Ser Ala Val Leu Ser  Glu Val Ser Ile Gly  Ala Thr Thr 
    7265                 7270                 7275             


Glu Ile  Ser Arg Thr Glu Val  Thr Ser Ser Ser Arg  Thr Ser Ile 
    7280                 7285                 7290             


Ser Gly  Ser Ala Glu Ser Thr  Met Leu Pro Glu Ile  Ser Thr Thr 
    7295                 7300                 7305             


Arg Lys  Ile Ile Lys Phe Pro  Thr Ser Pro Ile Leu  Ala Glu Ser 
    7310                 7315                 7320             


Ser Glu  Met Thr Ile Lys Thr  Gln Thr Ser Pro Pro  Gly Ser Thr 
    7325                 7330                 7335             


Ser Glu  Ser Thr Phe Thr Leu  Asp Thr Ser Thr Thr  Pro Ser Leu 
    7340                 7345                 7350             


Val Ile  Thr His Ser Thr Met  Thr Gln Arg Leu Pro  His Ser Glu 
    7355                 7360                 7365             


Ile Thr  Thr Leu Val Ser Arg  Gly Ala Gly Asp Val  Pro Arg Pro 
    7370                 7375                 7380             


Ser Ser  Leu Pro Val Glu Glu  Thr Ser Pro Pro Ser  Ser Gln Leu 
    7385                 7390                 7395             


Ser Leu  Ser Ala Met Ile Ser  Pro Ser Pro Val Ser  Ser Thr Leu 
    7400                 7405                 7410             


Pro Ala  Ser Ser His Ser Ser  Ser Ala Ser Val Thr  Ser Pro Leu 
    7415                 7420                 7425             


Thr Pro  Gly Gln Val Lys Thr  Thr Glu Val Leu Asp  Ala Ser Ala 
    7430                 7435                 7440             


Glu Pro  Glu Thr Ser Ser Pro  Pro Ser Leu Ser Ser  Thr Ser Val 
    7445                 7450                 7455             


Glu Ile  Leu Ala Thr Ser Glu  Val Thr Thr Asp Thr  Glu Lys Ile 
    7460                 7465                 7470             


His Pro  Phe Pro Asn Thr Ala  Val Thr Lys Val Gly  Thr Ser Ser 
    7475                 7480                 7485             


Ser Gly  His Glu Ser Pro Ser  Ser Val Leu Pro Asp  Ser Glu Thr 
    7490                 7495                 7500             


Thr Lys  Ala Thr Ser Ala Met  Gly Thr Ile Ser Ile  Met Gly Asp 
    7505                 7510                 7515             


Thr Ser  Val Ser Thr Leu Thr  Pro Ala Leu Ser Asn  Thr Arg Lys 
    7520                 7525                 7530             


Ile Gln  Ser Glu Pro Ala Ser  Ser Leu Thr Thr Arg  Leu Arg Glu 
    7535                 7540                 7545             


Thr Ser  Thr Ser Glu Glu Thr  Ser Leu Ala Thr Glu  Ala Asn Thr 
    7550                 7555                 7560             


Val Leu  Ser Lys Val Ser Thr  Gly Ala Thr Thr Glu  Val Ser Arg 
    7565                 7570                 7575             


Thr Glu  Ala Ile Ser Phe Ser  Arg Thr Ser Met Ser  Gly Pro Glu 
    7580                 7585                 7590             


Gln Ser  Thr Met Ser Gln Asp  Ile Ser Ile Gly Thr  Ile Pro Arg 
    7595                 7600                 7605             


Ile Ser  Ala Ser Ser Val Leu  Thr Glu Ser Ala Lys  Met Thr Ile 
    7610                 7615                 7620             


Thr Thr  Gln Thr Gly Pro Ser  Glu Ser Thr Leu Glu  Ser Thr Leu 
    7625                 7630                 7635             


Asn Leu  Asn Thr Ala Thr Thr  Pro Ser Trp Val Glu  Thr His Ser 
    7640                 7645                 7650             


Ile Val  Ile Gln Gly Phe Pro  His Pro Glu Met Thr  Thr Ser Met 
    7655                 7660                 7665             


Gly Arg  Gly Pro Gly Gly Val  Ser Trp Pro Ser Pro  Pro Phe Val 
    7670                 7675                 7680             


Lys Glu  Thr Ser Pro Pro Ser  Ser Pro Leu Ser Leu  Pro Ala Val 
    7685                 7690                 7695             


Thr Ser  Pro His Pro Val Ser  Thr Thr Phe Leu Ala  His Ile Pro 
    7700                 7705                 7710             


Pro Ser  Pro Leu Pro Val Thr  Ser Leu Leu Thr Ser  Gly Pro Ala 
    7715                 7720                 7725             


Thr Thr  Thr Asp Ile Leu Gly  Thr Ser Thr Glu Pro  Gly Thr Ser 
    7730                 7735                 7740             


Ser Ser  Ser Ser Leu Ser Thr  Thr Ser His Glu Arg  Leu Thr Thr 
    7745                 7750                 7755             


Tyr Lys  Asp Thr Ala His Thr  Glu Ala Val His Pro  Ser Thr Asn 
    7760                 7765                 7770             


Thr Gly  Gly Thr Asn Val Ala  Thr Thr Ser Ser Gly  Tyr Lys Ser 
    7775                 7780                 7785             


Gln Ser  Ser Val Leu Ala Asp  Ser Ser Pro Met Cys  Thr Thr Ser 
    7790                 7795                 7800             


Thr Met  Gly Asp Thr Ser Val  Leu Thr Ser Thr Pro  Ala Phe Leu 
    7805                 7810                 7815             


Glu Thr  Arg Arg Ile Gln Thr  Glu Leu Ala Ser Ser  Leu Thr Pro 
    7820                 7825                 7830             


Gly Leu  Arg Glu Ser Ser Gly  Ser Glu Gly Thr Ser  Ser Gly Thr 
    7835                 7840                 7845             


Lys Met  Ser Thr Val Leu Ser  Lys Val Pro Thr Gly  Ala Thr Thr 
    7850                 7855                 7860             


Glu Ile  Ser Lys Glu Asp Val  Thr Ser Ile Pro Gly  Pro Ala Gln 
    7865                 7870                 7875             


Ser Thr  Ile Ser Pro Asp Ile  Ser Thr Arg Thr Val  Ser Trp Phe 
    7880                 7885                 7890             


Ser Thr  Ser Pro Val Met Thr  Glu Ser Ala Glu Ile  Thr Met Asn 
    7895                 7900                 7905             


Thr His  Thr Ser Pro Leu Gly  Ala Thr Thr Gln Gly  Thr Ser Thr 
    7910                 7915                 7920             


Leu Ala  Thr Ser Ser Thr Thr  Ser Leu Thr Met Thr  His Ser Thr 
    7925                 7930                 7935             


Ile Ser  Gln Gly Phe Ser His  Ser Gln Met Ser Thr  Leu Met Arg 
    7940                 7945                 7950             


Arg Gly  Pro Glu Asp Val Ser  Trp Met Ser Pro Pro  Leu Leu Glu 
    7955                 7960                 7965             


Lys Thr  Arg Pro Ser Phe Ser  Leu Met Ser Ser Pro  Ala Thr Thr 
    7970                 7975                 7980             


Ser Pro  Ser Pro Val Ser Ser  Thr Leu Pro Glu Ser  Ile Ser Ser 
    7985                 7990                 7995             


Ser Pro  Leu Pro Val Thr Ser  Leu Leu Thr Ser Gly  Leu Ala Lys 
    8000                 8005                 8010             


Thr Thr  Asp Met Leu His Lys  Ser Ser Glu Pro Val  Thr Asn Ser 
    8015                 8020                 8025             


Pro Ala  Asn Leu Ser Ser Thr  Ser Val Glu Ile Leu  Ala Thr Ser 
    8030                 8035                 8040             


Glu Val  Thr Thr Asp Thr Glu  Lys Thr His Pro Ser  Ser Asn Arg 
    8045                 8050                 8055             


Thr Val  Thr Asp Val Gly Thr  Ser Ser Ser Gly His  Glu Ser Thr 
    8060                 8065                 8070             


Ser Phe  Val Leu Ala Asp Ser  Gln Thr Ser Lys Val  Thr Ser Pro 
    8075                 8080                 8085             


Met Val  Ile Thr Ser Thr Met  Glu Asp Thr Ser Val  Ser Thr Ser 
    8090                 8095                 8100             


Thr Pro  Gly Phe Phe Glu Thr  Ser Arg Ile Gln Thr  Glu Pro Thr 
    8105                 8110                 8115             


Ser Ser  Leu Thr Leu Gly Leu  Arg Lys Thr Ser Ser  Ser Glu Gly 
    8120                 8125                 8130             


Thr Ser  Leu Ala Thr Glu Met  Ser Thr Val Leu Ser  Gly Val Pro 
    8135                 8140                 8145             


Thr Gly  Ala Thr Ala Glu Val  Ser Arg Thr Glu Val  Thr Ser Ser 
    8150                 8155                 8160             


Ser Arg  Thr Ser Ile Ser Gly  Phe Ala Gln Leu Thr  Val Ser Pro 
    8165                 8170                 8175             


Glu Thr  Ser Thr Glu Thr Ile  Thr Arg Leu Pro Thr  Ser Ser Ile 
    8180                 8185                 8190             


Met Thr  Glu Ser Ala Glu Met  Met Ile Lys Thr Gln  Thr Asp Pro 
    8195                 8200                 8205             


Pro Gly  Ser Thr Pro Glu Ser  Thr His Thr Val Asp  Ile Ser Thr 
    8210                 8215                 8220             


Thr Pro  Asn Trp Val Glu Thr  His Ser Thr Val Thr  Gln Arg Phe 
    8225                 8230                 8235             


Ser His  Ser Glu Met Thr Thr  Leu Val Ser Arg Ser  Pro Gly Asp 
    8240                 8245                 8250             


Met Leu  Trp Pro Ser Gln Ser  Ser Val Glu Glu Thr  Ser Ser Ala 
    8255                 8260                 8265             


Ser Ser  Leu Leu Ser Leu Pro  Ala Thr Thr Ser Pro  Ser Pro Val 
    8270                 8275                 8280             


Ser Ser  Thr Leu Val Glu Asp  Phe Pro Ser Ala Ser  Leu Pro Val 
    8285                 8290                 8295             


Thr Ser  Leu Leu Thr Pro Gly  Leu Val Ile Thr Thr  Asp Arg Met 
    8300                 8305                 8310             


Gly Ile  Ser Arg Glu Pro Gly  Thr Ser Ser Thr Ser  Asn Leu Ser 
    8315                 8320                 8325             


Ser Thr  Ser His Glu Arg Leu  Thr Thr Leu Glu Asp  Thr Val Asp 
    8330                 8335                 8340             


Thr Glu  Asp Met Gln Pro Ser  Thr His Thr Ala Val  Thr Asn Val 
    8345                 8350                 8355             


Arg Thr  Ser Ile Ser Gly His  Glu Ser Gln Ser Ser  Val Leu Ser 
    8360                 8365                 8370             


Asp Ser  Glu Thr Pro Lys Ala  Thr Ser Pro Met Gly  Thr Thr Tyr 
    8375                 8380                 8385             


Thr Met  Gly Glu Thr Ser Val  Ser Ile Ser Thr Ser  Asp Phe Phe 
    8390                 8395                 8400             


Glu Thr  Ser Arg Ile Gln Ile  Glu Pro Thr Ser Ser  Leu Thr Ser 
    8405                 8410                 8415             


Gly Leu  Arg Glu Thr Ser Ser  Ser Glu Arg Ile Ser  Ser Ala Thr 
    8420                 8425                 8430             


Glu Gly  Ser Thr Val Leu Ser  Glu Val Pro Ser Gly  Ala Thr Thr 
    8435                 8440                 8445             


Glu Val  Ser Arg Thr Glu Val  Ile Ser Ser Arg Gly  Thr Ser Met 
    8450                 8455                 8460             


Ser Gly  Pro Asp Gln Phe Thr  Ile Ser Pro Asp Ile  Ser Thr Glu 
    8465                 8470                 8475             


Ala Ile  Thr Arg Leu Ser Thr  Ser Pro Ile Met Thr  Glu Ser Ala 
    8480                 8485                 8490             


Glu Ser  Ala Ile Thr Ile Glu  Thr Gly Ser Pro Gly  Ala Thr Ser 
    8495                 8500                 8505             


Glu Gly  Thr Leu Thr Leu Asp  Thr Ser Thr Thr Thr  Phe Trp Ser 
    8510                 8515                 8520             


Gly Thr  His Ser Thr Ala Ser  Pro Gly Phe Ser His  Ser Glu Met 
    8525                 8530                 8535             


Thr Thr  Leu Met Ser Arg Thr  Pro Gly Asp Val Pro  Trp Pro Ser 
    8540                 8545                 8550             


Leu Pro  Ser Val Glu Glu Ala  Ser Ser Val Ser Ser  Ser Leu Ser 
    8555                 8560                 8565             


Ser Pro  Ala Met Thr Ser Thr  Ser Phe Phe Ser Ala  Leu Pro Glu 
    8570                 8575                 8580             


Ser Ile  Ser Ser Ser Pro His  Pro Val Thr Ala Leu  Leu Thr Leu 
    8585                 8590                 8595             


Gly Pro  Val Lys Thr Thr Asp  Met Leu Arg Thr Ser  Ser Glu Pro 
    8600                 8605                 8610             


Glu Thr  Ser Ser Pro Pro Asn  Leu Ser Ser Thr Ser  Ala Glu Ile 
    8615                 8620                 8625             


Leu Ala  Thr Ser Glu Val Thr  Lys Asp Arg Glu Lys  Ile His Pro 
    8630                 8635                 8640             


Ser Ser  Asn Thr Pro Val Val  Asn Val Gly Thr Val  Ile Tyr Lys 
    8645                 8650                 8655             


His Leu  Ser Pro Ser Ser Val  Leu Ala Asp Leu Val  Thr Thr Lys 
    8660                 8665                 8670             


Pro Thr  Ser Pro Met Ala Thr  Thr Ser Thr Leu Gly  Asn Thr Ser 
    8675                 8680                 8685             


Val Ser  Thr Ser Thr Pro Ala  Phe Pro Glu Thr Met  Met Thr Gln 
    8690                 8695                 8700             


Pro Thr  Ser Ser Leu Thr Ser  Gly Leu Arg Glu Ile  Ser Thr Ser 
    8705                 8710                 8715             


Gln Glu  Thr Ser Ser Ala Thr  Glu Arg Ser Ala Ser  Leu Ser Gly 
    8720                 8725                 8730             


Met Pro  Thr Gly Ala Thr Thr  Lys Val Ser Arg Thr  Glu Ala Leu 
    8735                 8740                 8745             


Ser Leu  Gly Arg Thr Ser Thr  Pro Gly Pro Ala Gln  Ser Thr Ile 
    8750                 8755                 8760             


Ser Pro  Glu Ile Ser Thr Glu  Thr Ile Thr Arg Ile  Ser Thr Pro 
    8765                 8770                 8775             


Leu Thr  Thr Thr Gly Ser Ala  Glu Met Thr Ile Thr  Pro Lys Thr 
    8780                 8785                 8790             


Gly His  Ser Gly Ala Ser Ser  Gln Gly Thr Phe Thr  Leu Asp Thr 
    8795                 8800                 8805             


Ser Ser  Arg Ala Ser Trp Pro  Gly Thr His Ser Ala  Ala Thr His 
    8810                 8815                 8820             


Arg Ser  Pro His Ser Gly Met  Thr Thr Pro Met Ser  Arg Gly Pro 
    8825                 8830                 8835             


Glu Asp  Val Ser Trp Pro Ser  Arg Pro Ser Val Glu  Lys Thr Ser 
    8840                 8845                 8850             


Pro Pro  Ser Ser Leu Val Ser  Leu Ser Ala Val Thr  Ser Pro Ser 
    8855                 8860                 8865             


Pro Leu  Tyr Ser Thr Pro Ser  Glu Ser Ser His Ser  Ser Pro Leu 
    8870                 8875                 8880             


Arg Val  Thr Ser Leu Phe Thr  Pro Val Met Met Lys  Thr Thr Asp 
    8885                 8890                 8895             


Met Leu  Asp Thr Ser Leu Glu  Pro Val Thr Thr Ser  Pro Pro Ser 
    8900                 8905                 8910             


Met Asn  Ile Thr Ser Asp Glu  Ser Leu Ala Thr Ser  Lys Ala Thr 
    8915                 8920                 8925             


Met Glu  Thr Glu Ala Ile Gln  Leu Ser Glu Asn Thr  Ala Val Thr 
    8930                 8935                 8940             


Gln Met  Gly Thr Ile Ser Ala  Arg Gln Glu Phe Tyr  Ser Ser Tyr 
    8945                 8950                 8955             


Pro Gly  Leu Pro Glu Pro Ser  Lys Val Thr Ser Pro  Val Val Thr 
    8960                 8965                 8970             


Ser Ser  Thr Ile Lys Asp Ile  Val Ser Thr Thr Ile  Pro Ala Ser 
    8975                 8980                 8985             


Ser Glu  Ile Thr Arg Ile Glu  Met Glu Ser Thr Ser  Thr Leu Thr 
    8990                 8995                 9000             


Pro Thr  Pro Arg Glu Thr Ser  Thr Ser Gln Glu Ile  His Ser Ala 
    9005                 9010                 9015             


Thr Lys  Pro Ser Thr Val Pro  Tyr Lys Ala Leu Thr  Ser Ala Thr 
    9020                 9025                 9030             


Ile Glu  Asp Ser Met Thr Gln  Val Met Ser Ser Ser  Arg Gly Pro 
    9035                 9040                 9045             


Ser Pro  Asp Gln Ser Thr Met  Ser Gln Asp Ile Ser  Ser Glu Val 
    9050                 9055                 9060             


Ile Thr  Arg Leu Ser Thr Ser  Pro Ile Lys Ala Glu  Ser Thr Glu 
    9065                 9070                 9075             


Met Thr  Ile Thr Thr Gln Thr  Gly Ser Pro Gly Ala  Thr Ser Arg 
    9080                 9085                 9090             


Gly Thr  Leu Thr Leu Asp Thr  Ser Thr Thr Phe Met  Ser Gly Thr 
    9095                 9100                 9105             


His Ser  Thr Ala Ser Gln Gly  Phe Ser His Ser Gln  Met Thr Ala 
    9110                 9115                 9120             


Leu Met  Ser Arg Thr Pro Gly  Asp Val Pro Trp Leu  Ser His Pro 
    9125                 9130                 9135             


Ser Val  Glu Glu Ala Ser Ser  Ala Ser Phe Ser Leu  Ser Ser Pro 
    9140                 9145                 9150             


Val Met  Thr Ser Ser Ser Pro  Val Ser Ser Thr Leu  Pro Asp Ser 
    9155                 9160                 9165             


Ile His  Ser Ser Ser Leu Pro  Val Thr Ser Leu Leu  Thr Ser Gly 
    9170                 9175                 9180             


Leu Val  Lys Thr Thr Glu Leu  Leu Gly Thr Ser Ser  Glu Pro Glu 
    9185                 9190                 9195             


Thr Ser  Ser Pro Pro Asn Leu  Ser Ser Thr Ser Ala  Glu Ile Leu 
    9200                 9205                 9210             


Ala Thr  Thr Glu Val Thr Thr  Asp Thr Glu Lys Leu  Glu Met Thr 
    9215                 9220                 9225             


Asn Val  Val Thr Ser Gly Tyr  Thr His Glu Ser Pro  Ser Ser Val 
    9230                 9235                 9240             


Leu Ala  Asp Ser Val Thr Thr  Lys Ala Thr Ser Ser  Met Gly Ile 
    9245                 9250                 9255             


Thr Tyr  Pro Thr Gly Asp Thr  Asn Val Leu Thr Ser  Thr Pro Ala 
    9260                 9265                 9270             


Phe Ser  Asp Thr Ser Arg Ile  Gln Thr Lys Ser Lys  Leu Ser Leu 
    9275                 9280                 9285             


Thr Pro  Gly Leu Met Glu Thr  Ser Ile Ser Glu Glu  Thr Ser Ser 
    9290                 9295                 9300             


Ala Thr  Glu Lys Ser Thr Val  Leu Ser Ser Val Pro  Thr Gly Ala 
    9305                 9310                 9315             


Thr Thr  Glu Val Ser Arg Thr  Glu Ala Ile Ser Ser  Ser Arg Thr 
    9320                 9325                 9330             


Ser Ile  Pro Gly Pro Ala Gln  Ser Thr Met Ser Ser  Asp Thr Ser 
    9335                 9340                 9345             


Met Glu  Thr Ile Thr Arg Ile  Ser Thr Pro Leu Thr  Arg Lys Glu 
    9350                 9355                 9360             


Ser Thr  Asp Met Ala Ile Thr  Pro Lys Thr Gly Pro  Ser Gly Ala 
    9365                 9370                 9375             


Thr Ser  Gln Gly Thr Phe Thr  Leu Asp Ser Ser Ser  Thr Ala Ser 
    9380                 9385                 9390             


Trp Pro  Gly Thr His Ser Ala  Thr Thr Gln Arg Phe  Pro Gln Ser 
    9395                 9400                 9405             


Val Val  Thr Thr Pro Met Ser  Arg Gly Pro Glu Asp  Val Ser Trp 
    9410                 9415                 9420             


Pro Ser  Pro Leu Ser Val Glu  Lys Asn Ser Pro Pro  Ser Ser Leu 
    9425                 9430                 9435             


Val Ser  Ser Ser Ser Val Thr  Ser Pro Ser Pro Leu  Tyr Ser Thr 
    9440                 9445                 9450             


Pro Ser  Gly Ser Ser His Ser  Ser Pro Val Pro Val  Thr Ser Leu 
    9455                 9460                 9465             


Phe Thr  Ser Ile Met Met Lys  Ala Thr Asp Met Leu  Asp Ala Ser 
    9470                 9475                 9480             


Leu Glu  Pro Glu Thr Thr Ser  Ala Pro Asn Met Asn  Ile Thr Ser 
    9485                 9490                 9495             


Asp Glu  Ser Leu Ala Thr Ser  Lys Ala Thr Thr Glu  Thr Glu Ala 
    9500                 9505                 9510             


Ile His  Val Phe Glu Asn Thr  Ala Ala Ser His Val  Glu Thr Thr 
    9515                 9520                 9525             


Ser Ala  Thr Glu Glu Leu Tyr  Ser Ser Ser Pro Gly  Phe Ser Glu 
    9530                 9535                 9540             


Pro Thr  Lys Val Ile Ser Pro  Val Val Thr Ser Ser  Ser Ile Arg 
    9545                 9550                 9555             


Asp Asn  Met Val Ser Thr Thr  Met Pro Gly Ser Ser  Gly Ile Thr 
    9560                 9565                 9570             


Arg Ile  Glu Ile Glu Ser Met  Ser Ser Leu Thr Pro  Gly Leu Arg 
    9575                 9580                 9585             


Glu Thr  Arg Thr Ser Gln Asp  Ile Thr Ser Ser Thr  Glu Thr Ser 
    9590                 9595                 9600             


Thr Val  Leu Tyr Lys Met Ser  Ser Gly Ala Thr Pro  Glu Val Ser 
    9605                 9610                 9615             


Arg Thr  Glu Val Met Pro Ser  Ser Arg Thr Ser Ile  Pro Gly Pro 
    9620                 9625                 9630             


Ala Gln  Ser Thr Met Ser Leu  Asp Ile Ser Asp Glu  Val Val Thr 
    9635                 9640                 9645             


Arg Leu  Ser Thr Ser Pro Ile  Met Thr Glu Ser Ala  Glu Ile Thr 
    9650                 9655                 9660             


Ile Thr  Thr Gln Thr Gly Tyr  Ser Leu Ala Thr Ser  Gln Val Thr 
    9665                 9670                 9675             


Leu Pro  Leu Gly Thr Ser Met  Thr Phe Leu Ser Gly  Thr His Ser 
    9680                 9685                 9690             


Thr Met  Ser Gln Gly Leu Ser  His Ser Glu Met Thr  Asn Leu Met 
    9695                 9700                 9705             


Ser Arg  Gly Pro Glu Ser Leu  Ser Trp Thr Ser Pro  Arg Phe Val 
    9710                 9715                 9720             


Glu Thr  Thr Arg Ser Ser Ser  Ser Leu Thr Ser Leu  Pro Leu Thr 
    9725                 9730                 9735             


Thr Ser  Leu Ser Pro Val Ser  Ser Thr Leu Leu Asp  Ser Ser Pro 
    9740                 9745                 9750             


Ser Ser  Pro Leu Pro Val Thr  Ser Leu Ile Leu Pro  Gly Leu Val 
    9755                 9760                 9765             


Lys Thr  Thr Glu Val Leu Asp  Thr Ser Ser Glu Pro  Lys Thr Ser 
    9770                 9775                 9780             


Ser Ser  Pro Asn Leu Ser Ser  Thr Ser Val Glu Ile  Pro Ala Thr 
    9785                 9790                 9795             


Ser Glu  Ile Met Thr Asp Thr  Glu Lys Ile His Pro  Ser Ser Asn 
    9800                 9805                 9810             


Thr Ala  Val Ala Lys Val Arg  Thr Ser Ser Ser Val  His Glu Ser 
    9815                 9820                 9825             


His Ser  Ser Val Leu Ala Asp  Ser Glu Thr Thr Ile  Thr Ile Pro 
    9830                 9835                 9840             


Ser Met  Gly Ile Thr Ser Ala  Val Asp Asp Thr Thr  Val Phe Thr 
    9845                 9850                 9855             


Ser Asn  Pro Ala Phe Ser Glu  Thr Arg Arg Ile Pro  Thr Glu Pro 
    9860                 9865                 9870             


Thr Phe  Ser Leu Thr Pro Gly  Phe Arg Glu Thr Ser  Thr Ser Glu 
    9875                 9880                 9885             


Glu Thr  Thr Ser Ile Thr Glu  Thr Ser Ala Val Leu  Tyr Gly Val 
    9890                 9895                 9900             


Pro Thr  Ser Ala Thr Thr Glu  Val Ser Met Thr Glu  Ile Met Ser 
    9905                 9910                 9915             


Ser Asn  Arg Thr His Ile Pro  Asp Ser Asp Gln Ser  Thr Met Ser 
    9920                 9925                 9930             


Pro Asp  Ile Ile Thr Glu Val  Ile Thr Arg Leu Ser  Ser Ser Ser 
    9935                 9940                 9945             


Met Met  Ser Glu Ser Thr Gln  Met Thr Ile Thr Thr  Gln Lys Ser 
    9950                 9955                 9960             


Ser Pro  Gly Ala Thr Ala Gln  Ser Thr Leu Thr Leu  Ala Thr Thr 
    9965                 9970                 9975             


Thr Ala  Pro Leu Ala Arg Thr  His Ser Thr Val Pro  Pro Arg Phe 
    9980                 9985                 9990             


Leu His  Ser Glu Met Thr Thr   Leu Met Ser Arg Ser   Pro Glu Asn 
    9995                 10000                 10005             


Pro Ser   Trp Lys Ser Ser Pro   Phe Val Glu Lys Thr   Ser Ser Ser 
    10010                 10015                 10020             


Ser Ser   Leu Leu Ser Leu Pro   Val Thr Thr Ser Pro   Ser Val Ser 
    10025                 10030                 10035             


Ser Thr   Leu Pro Gln Ser Ile   Pro Ser Ser Ser Phe   Ser Val Thr 
    10040                 10045                 10050             


Ser Leu   Leu Thr Pro Gly Met   Val Lys Thr Thr Asp   Thr Ser Thr 
    10055                 10060                 10065             


Glu Pro   Gly Thr Ser Leu Ser   Pro Asn Leu Ser Gly   Thr Ser Val 
    10070                 10075                 10080             


Glu Ile   Leu Ala Ala Ser Glu   Val Thr Thr Asp Thr   Glu Lys Ile 
    10085                 10090                 10095             


His Pro   Ser Ser Ser Met Ala   Val Thr Asn Val Gly   Thr Thr Ser 
    10100                 10105                 10110             


Ser Gly   His Glu Leu Tyr Ser   Ser Val Ser Ile His   Ser Glu Pro 
    10115                 10120                 10125             


Ser Lys   Ala Thr Tyr Pro Val   Gly Thr Pro Ser Ser   Met Ala Glu 
    10130                 10135                 10140             


Thr Ser   Ile Ser Thr Ser Met   Pro Ala Asn Phe Glu   Thr Thr Gly 
    10145                 10150                 10155             


Phe Glu   Ala Glu Pro Phe Ser   His Leu Thr Ser Gly   Phe Arg Lys 
    10160                 10165                 10170             


Thr Asn   Met Ser Leu Asp Thr   Ser Ser Val Thr Pro   Thr Asn Thr 
    10175                 10180                 10185             


Pro Ser   Ser Pro Gly Ser Thr   His Leu Leu Gln Ser   Ser Lys Thr 
    10190                 10195                 10200             


Asp Phe   Thr Ser Ser Ala Lys   Thr Ser Ser Pro Asp   Trp Pro Pro 
    10205                 10210                 10215             


Ala Ser   Gln Tyr Thr Glu Ile   Pro Val Asp Ile Ile   Thr Pro Phe 
    10220                 10225                 10230             


Asn Ala   Ser Pro Ser Ile Thr   Glu Ser Thr Gly Ile   Thr Ser Phe 
    10235                 10240                 10245             


Pro Glu   Ser Arg Phe Thr Met   Ser Val Thr Glu Ser   Thr His His 
    10250                 10255                 10260             


Leu Ser   Thr Asp Leu Leu Pro   Ser Ala Glu Thr Ile   Ser Thr Gly 
    10265                 10270                 10275             


Thr Val   Met Pro Ser Leu Ser   Glu Ala Met Thr Ser   Phe Ala Thr 
    10280                 10285                 10290             


Thr Gly   Val Pro Arg Ala Ile   Ser Gly Ser Gly Ser   Pro Phe Ser 
    10295                 10300                 10305             


Arg Thr   Glu Ser Gly Pro Gly   Asp Ala Thr Leu Ser   Thr Ile Ala 
    10310                 10315                 10320             


Glu Ser   Leu Pro Ser Ser Thr   Pro Val Pro Phe Ser   Ser Ser Thr 
    10325                 10330                 10335             


Phe Thr   Thr Thr Asp Ser Ser   Thr Ile Pro Ala Leu   His Glu Ile 
    10340                 10345                 10350             


Thr Ser   Ser Ser Ala Thr Pro   Tyr Arg Val Asp Thr   Ser Leu Gly 
    10355                 10360                 10365             


Thr Glu   Ser Ser Thr Thr Glu   Gly Arg Leu Val Met   Val Ser Thr 
    10370                 10375                 10380             


Leu Asp   Thr Ser Ser Gln Pro   Gly Arg Thr Ser Ser   Thr Pro Ile 
    10385                 10390                 10395             


Leu Asp   Thr Arg Met Thr Glu   Ser Val Glu Leu Gly   Thr Val Thr 
    10400                 10405                 10410             


Ser Ala   Tyr Gln Val Pro Ser   Leu Ser Thr Arg Leu   Thr Arg Thr 
    10415                 10420                 10425             


Asp Gly   Ile Met Glu His Ile   Thr Lys Ile Pro Asn   Glu Ala Ala 
    10430                 10435                 10440             


His Arg   Gly Thr Ile Arg Pro   Val Lys Gly Pro Gln   Thr Ser Thr 
    10445                 10450                 10455             


Ser Pro   Ala Ser Pro Lys Gly   Leu His Thr Gly Gly   Thr Lys Arg 
    10460                 10465                 10470             


Met Glu   Thr Thr Thr Thr Ala   Leu Lys Thr Thr Thr   Thr Ala Leu 
    10475                 10480                 10485             


Lys Thr   Thr Ser Arg Ala Thr   Leu Thr Thr Ser Val   Tyr Thr Pro 
    10490                 10495                 10500             


Thr Leu   Gly Thr Leu Thr Pro   Leu Asn Ala Ser Arg   Gln Met Ala 
    10505                 10510                 10515             


Ser Thr   Ile Leu Thr Glu Met   Met Ile Thr Thr Pro   Tyr Val Phe 
    10520                 10525                 10530             


Pro Asp   Val Pro Glu Thr Thr   Ser Ser Leu Ala Thr   Ser Leu Gly 
    10535                 10540                 10545             


Ala Glu   Thr Ser Thr Ala Leu   Pro Arg Thr Thr Pro   Ser Val Leu 
    10550                 10555                 10560             


Asn Arg   Glu Ser Glu Thr Thr   Ala Ser Leu Val Ser   Arg Ser Gly 
    10565                 10570                 10575             


Ala Glu   Arg Ser Pro Val Ile   Gln Thr Leu Asp Val   Ser Ser Ser 
    10580                 10585                 10590             


Glu Pro   Asp Thr Thr Ala Ser   Trp Val Ile His Pro   Ala Glu Thr 
    10595                 10600                 10605             


Ile Pro   Thr Val Ser Lys Thr   Thr Pro Asn Phe Phe   His Ser Glu 
    10610                 10615                 10620             


Leu Asp   Thr Val Ser Ser Thr   Ala Thr Ser His Gly   Ala Asp Val 
    10625                 10630                 10635             


Ser Ser   Ala Ile Pro Thr Asn   Ile Ser Pro Ser Glu   Leu Asp Ala 
    10640                 10645                 10650             


Leu Thr   Pro Leu Val Thr Ile   Ser Gly Thr Asp Thr   Ser Thr Thr 
    10655                 10660                 10665             


Phe Pro   Thr Leu Thr Lys Ser   Pro His Glu Thr Glu   Thr Arg Thr 
    10670                 10675                 10680             


Thr Trp   Leu Thr His Pro Ala   Glu Thr Ser Ser Thr   Ile Pro Arg 
    10685                 10690                 10695             


Thr Ile   Pro Asn Phe Ser His   His Glu Ser Asp Ala   Thr Pro Ser 
    10700                 10705                 10710             


Ile Ala   Thr Ser Pro Gly Ala   Glu Thr Ser Ser Ala   Ile Pro Ile 
    10715                 10720                 10725             


Met Thr   Val Ser Pro Gly Ala   Glu Asp Leu Val Thr   Ser Gln Val 
    10730                 10735                 10740             


Thr Ser   Ser Gly Thr Asp Arg   Asn Met Thr Ile Pro   Thr Leu Thr 
    10745                 10750                 10755             


Leu Ser   Pro Gly Glu Pro Lys   Thr Ile Ala Ser Leu   Val Thr His 
    10760                 10765                 10770             


Pro Glu   Ala Gln Thr Ser Ser   Ala Ile Pro Thr Ser   Thr Ile Ser 
    10775                 10780                 10785             


Pro Ala   Val Ser Arg Leu Val   Thr Ser Met Val Thr   Ser Leu Ala 
    10790                 10795                 10800             


Ala Lys   Thr Ser Thr Thr Asn   Arg Ala Leu Thr Asn   Ser Pro Gly 
    10805                 10810                 10815             


Glu Pro   Ala Thr Thr Val Ser   Leu Val Thr His Pro   Ala Gln Thr 
    10820                 10825                 10830             


Ser Pro   Thr Val Pro Trp Thr   Thr Ser Ile Phe Phe   His Ser Lys 
    10835                 10840                 10845             


Ser Asp   Thr Thr Pro Ser Met   Thr Thr Ser His Gly   Ala Glu Ser 
    10850                 10855                 10860             


Ser Ser   Ala Val Pro Thr Pro   Thr Val Ser Thr Glu   Val Pro Gly 
    10865                 10870                 10875             


Val Val   Thr Pro Leu Val Thr   Ser Ser Arg Ala Val   Ile Ser Thr 
    10880                 10885                 10890             


Thr Ile   Pro Ile Leu Thr Leu   Ser Pro Gly Glu Pro   Glu Thr Thr 
    10895                 10900                 10905             


Pro Ser   Met Ala Thr Ser His   Gly Glu Glu Ala Ser   Ser Ala Ile 
    10910                 10915                 10920             


Pro Thr   Pro Thr Val Ser Pro   Gly Val Pro Gly Val   Val Thr Ser 
    10925                 10930                 10935             


Leu Val   Thr Ser Ser Arg Ala   Val Thr Ser Thr Thr   Ile Pro Ile 
    10940                 10945                 10950             


Leu Thr   Phe Ser Leu Gly Glu   Pro Glu Thr Thr Pro   Ser Met Ala 
    10955                 10960                 10965             


Thr Ser   His Gly Thr Glu Ala   Gly Ser Ala Val Pro   Thr Val Leu 
    10970                 10975                 10980             


Pro Glu   Val Pro Gly Met Val   Thr Ser Leu Val Ala   Ser Ser Arg 
    10985                 10990                 10995             


Ala Val   Thr Ser Thr Thr Leu   Pro Thr Leu Thr Leu   Ser Pro Gly 
    11000                 11005                 11010             


Glu Pro   Glu Thr Thr Pro Ser   Met Ala Thr Ser His   Gly Ala Glu 
    11015                 11020                 11025             


Ala Ser   Ser Thr Val Pro Thr   Val Ser Pro Glu Val   Pro Gly Val 
    11030                 11035                 11040             


Val Thr   Ser Leu Val Thr Ser   Ser Ser Gly Val Asn   Ser Thr Ser 
    11045                 11050                 11055             


Ile Pro   Thr Leu Ile Leu Ser   Pro Gly Glu Leu Glu   Thr Thr Pro 
    11060                 11065                 11070             


Ser Met   Ala Thr Ser His Gly   Ala Glu Ala Ser Ser   Ala Val Pro 
    11075                 11080                 11085             


Thr Pro   Thr Val Ser Pro Gly   Val Ser Gly Val Val   Thr Pro Leu 
    11090                 11095                 11100             


Val Thr   Ser Ser Arg Ala Val   Thr Ser Thr Thr Ile   Pro Ile Leu 
    11105                 11110                 11115             


Thr Leu   Ser Ser Ser Glu Pro   Glu Thr Thr Pro Ser   Met Ala Thr 
    11120                 11125                 11130             


Ser His   Gly Val Glu Ala Ser   Ser Ala Val Leu Thr   Val Ser Pro 
    11135                 11140                 11145             


Glu Val   Pro Gly Met Val Thr   Ser Leu Val Thr Ser   Ser Arg Ala 
    11150                 11155                 11160             


Val Thr   Ser Thr Thr Ile Pro   Thr Leu Thr Ile Ser   Ser Asp Glu 
    11165                 11170                 11175             


Pro Glu   Thr Thr Thr Ser Leu   Val Thr His Ser Glu   Ala Lys Met 
    11180                 11185                 11190             


Ile Ser   Ala Ile Pro Thr Leu   Ala Val Ser Pro Thr   Val Gln Gly 
    11195                 11200                 11205             


Leu Val   Thr Ser Leu Val Thr   Ser Ser Gly Ser Glu   Thr Ser Ala 
    11210                 11215                 11220             


Phe Ser   Asn Leu Thr Val Ala   Ser Ser Gln Pro Glu   Thr Ile Asp 
    11225                 11230                 11235             


Ser Trp   Val Ala His Pro Gly   Thr Glu Ala Ser Ser   Val Val Pro 
    11240                 11245                 11250             


Thr Leu   Thr Val Ser Thr Gly   Glu Pro Phe Thr Asn   Ile Ser Leu 
    11255                 11260                 11265             


Val Thr   His Pro Ala Glu Ser   Ser Ser Thr Leu Pro   Arg Thr Thr 
    11270                 11275                 11280             


Ser Arg   Phe Ser His Ser Glu   Leu Asp Thr Met Pro   Ser Thr Val 
    11285                 11290                 11295             


Thr Ser   Pro Glu Ala Glu Ser   Ser Ser Ala Ile Ser   Thr Thr Ile 
    11300                 11305                 11310             


Ser Pro   Gly Ile Pro Gly Val   Leu Thr Ser Leu Val   Thr Ser Ser 
    11315                 11320                 11325             


Gly Arg   Asp Ile Ser Ala Thr   Phe Pro Thr Val Pro   Glu Ser Pro 
    11330                 11335                 11340             


His Glu   Ser Glu Ala Thr Ala   Ser Trp Val Thr His   Pro Ala Val 
    11345                 11350                 11355             


Thr Ser   Thr Thr Val Pro Arg   Thr Thr Pro Asn Tyr   Ser His Ser 
    11360                 11365                 11370             


Glu Pro   Asp Thr Thr Pro Ser   Ile Ala Thr Ser Pro   Gly Ala Glu 
    11375                 11380                 11385             


Ala Thr   Ser Asp Phe Pro Thr   Ile Thr Val Ser Pro   Asp Val Pro 
    11390                 11395                 11400             


Asp Met   Val Thr Ser Gln Val   Thr Ser Ser Gly Thr   Asp Thr Ser 
    11405                 11410                 11415             


Ile Thr   Ile Pro Thr Leu Thr   Leu Ser Ser Gly Glu   Pro Glu Thr 
    11420                 11425                 11430             


Thr Thr   Ser Phe Ile Thr Tyr   Ser Glu Thr His Thr   Ser Ser Ala 
    11435                 11440                 11445             


Ile Pro   Thr Leu Pro Val Ser   Pro Gly Ala Ser Lys   Met Leu Thr 
    11450                 11455                 11460             


Ser Leu   Val Ile Ser Ser Gly   Thr Asp Ser Thr Thr   Thr Phe Pro 
    11465                 11470                 11475             


Thr Leu   Thr Glu Thr Pro Tyr   Glu Pro Glu Thr Thr   Ala Ile Gln 
    11480                 11485                 11490             


Leu Ile   His Pro Ala Glu Thr   Asn Thr Met Val Pro   Lys Thr Thr 
    11495                 11500                 11505             


Pro Lys   Phe Ser His Ser Lys   Ser Asp Thr Thr Leu   Pro Val Ala 
    11510                 11515                 11520             


Ile Thr   Ser Pro Gly Pro Glu   Ala Ser Ser Ala Val   Ser Thr Thr 
    11525                 11530                 11535             


Thr Ile   Ser Pro Asp Met Ser   Asp Leu Val Thr Ser   Leu Val Pro 
    11540                 11545                 11550             


Ser Ser   Gly Thr Asp Thr Ser   Thr Thr Phe Pro Thr   Leu Ser Glu 
    11555                 11560                 11565             


Thr Pro   Tyr Glu Pro Glu Thr   Thr Val Thr Trp Leu   Thr His Pro 
    11570                 11575                 11580             


Ala Glu   Thr Ser Thr Thr Val   Ser Gly Thr Ile Pro   Asn Phe Ser 
    11585                 11590                 11595             


His Arg   Gly Ser Asp Thr Ala   Pro Ser Met Val Thr   Ser Pro Gly 
    11600                 11605                 11610             


Val Asp   Thr Arg Ser Gly Val   Pro Thr Thr Thr Ile   Pro Pro Ser 
    11615                 11620                 11625             


Ile Pro   Gly Val Val Thr Ser   Gln Val Thr Ser Ser   Ala Thr Asp 
    11630                 11635                 11640             


Thr Ser   Thr Ala Ile Pro Thr   Leu Thr Pro Ser Pro   Gly Glu Pro 
    11645                 11650                 11655             


Glu Thr   Thr Ala Ser Ser Ala   Thr His Pro Gly Thr   Gln Thr Gly 
    11660                 11665                 11670             


Phe Thr   Val Pro Ile Arg Thr   Val Pro Ser Ser Glu   Pro Asp Thr 
    11675                 11680                 11685             


Met Ala   Ser Trp Val Thr His   Pro Pro Gln Thr Ser   Thr Pro Val 
    11690                 11695                 11700             


Ser Arg   Thr Thr Ser Ser Phe   Ser His Ser Ser Pro   Asp Ala Thr 
    11705                 11710                 11715             


Pro Val   Met Ala Thr Ser Pro   Arg Thr Glu Ala Ser   Ser Ala Val 
    11720                 11725                 11730             


Leu Thr   Thr Ile Ser Pro Gly   Ala Pro Glu Met Val   Thr Ser Gln 
    11735                 11740                 11745             


Ile Thr   Ser Ser Gly Ala Ala   Thr Ser Thr Thr Val   Pro Thr Leu 
    11750                 11755                 11760             


Thr His   Ser Pro Gly Met Pro   Glu Thr Thr Ala Leu   Leu Ser Thr 
    11765                 11770                 11775             


His Pro   Arg Thr Gly Thr Ser   Lys Thr Phe Pro Ala   Ser Thr Val 
    11780                 11785                 11790             


Phe Pro   Gln Val Ser Glu Thr   Thr Ala Ser Leu Thr   Ile Arg Pro 
    11795                 11800                 11805             


Gly Ala   Glu Thr Ser Thr Ala   Leu Pro Thr Gln Thr   Thr Ser Ser 
    11810                 11815                 11820             


Leu Phe   Thr Leu Leu Val Thr   Gly Thr Ser Arg Val   Asp Leu Ser 
    11825                 11830                 11835             


Pro Thr   Ala Ser Pro Gly Val   Ser Ala Lys Thr Ala   Pro Leu Ser 
    11840                 11845                 11850             


Thr His   Pro Gly Thr Glu Thr   Ser Thr Met Ile Pro   Thr Ser Thr 
    11855                 11860                 11865             


Leu Ser   Leu Gly Leu Leu Glu   Thr Thr Gly Leu Leu   Ala Thr Ser 
    11870                 11875                 11880             


Ser Ser   Ala Glu Thr Ser Thr   Ser Thr Leu Thr Leu   Thr Val Ser 
    11885                 11890                 11895             


Pro Ala   Val Ser Gly Leu Ser   Ser Ala Ser Ile Thr   Thr Asp Lys 
    11900                 11905                 11910             


Pro Gln   Thr Val Thr Ser Trp   Asn Thr Glu Thr Ser   Pro Ser Val 
    11915                 11920                 11925             


Thr Ser   Val Gly Pro Pro Glu   Phe Ser Arg Thr Val   Thr Gly Thr 
    11930                 11935                 11940             


Thr Met   Thr Leu Ile Pro Ser   Glu Met Pro Thr Pro   Pro Lys Thr 
    11945                 11950                 11955             


Ser His   Gly Glu Gly Val Ser   Pro Thr Thr Ile Leu   Arg Thr Thr 
    11960                 11965                 11970             


Met Val   Glu Ala Thr Asn Leu   Ala Thr Thr Gly Ser   Ser Pro Thr 
    11975                 11980                 11985             


Val Ala   Lys Thr Thr Thr Thr   Phe Asn Thr Leu Ala   Gly Ser Leu 
    11990                 11995                 12000             


Phe Thr   Pro Leu Thr Thr Pro   Gly Met Ser Thr Leu   Ala Ser Glu 
    12005                 12010                 12015             


Ser Val   Thr Ser Arg Thr Ser   Tyr Asn His Arg Ser   Trp Ile Ser 
    12020                 12025                 12030             


Thr Thr   Ser Ser Tyr Asn Arg   Arg Tyr Trp Thr Pro   Ala Thr Ser 
    12035                 12040                 12045             


Thr Pro   Val Thr Ser Thr Phe   Ser Pro Gly Ile Ser   Thr Ser Ser 
    12050                 12055                 12060             


Ile Pro   Ser Ser Thr Ala Ala   Thr Val Pro Phe Met   Val Pro Phe 
    12065                 12070                 12075             


Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Gln Tyr Glu   Glu Asp Met 
    12080                 12085                 12090             


Arg His   Pro Gly Ser Arg Lys   Phe Asn Ala Thr Glu   Arg Glu Leu 
    12095                 12100                 12105             


Gln Gly   Leu Leu Lys Pro Leu   Phe Arg Asn Ser Ser   Leu Glu Tyr 
    12110                 12115                 12120             


Leu Tyr   Ser Gly Cys Arg Leu   Ala Ser Leu Arg Pro   Glu Lys Asp 
    12125                 12130                 12135             


Ser Ser   Ala Met Ala Val Asp   Ala Ile Cys Thr His   Arg Pro Asp 
    12140                 12145                 12150             


Pro Glu   Asp Leu Gly Leu Asp   Arg Glu Arg Leu Tyr   Trp Glu Leu 
    12155                 12160                 12165             


Ser Asn   Leu Thr Asn Gly Ile   Gln Glu Leu Gly Pro   Tyr Thr Leu 
    12170                 12175                 12180             


Asp Arg   Asn Ser Leu Tyr Val   Asn Gly Phe Thr His   Arg Ser Ser 
    12185                 12190                 12195             


Met Pro   Thr Thr Ser Thr Pro   Gly Thr Ser Thr Val   Asp Val Gly 
    12200                 12205                 12210             


Thr Ser   Gly Thr Pro Ser Ser   Ser Pro Ser Pro Thr   Ala Ala Gly 
    12215                 12220                 12225             


Pro Leu   Leu Met Pro Phe Thr   Leu Asn Phe Thr Ile   Thr Asn Leu 
    12230                 12235                 12240             


Gln Tyr   Glu Glu Asp Met Arg   Arg Thr Gly Ser Arg   Lys Phe Asn 
    12245                 12250                 12255             


Thr Met   Glu Ser Val Leu Gln   Gly Leu Leu Lys Pro   Leu Phe Lys 
    12260                 12265                 12270             


Asn Thr   Ser Val Gly Pro Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu 
    12275                 12280                 12285             


Leu Arg   Pro Glu Lys Asp Gly   Ala Ala Thr Gly Val   Asp Ala Ile 
    12290                 12295                 12300             


Cys Thr   His Arg Leu Asp Pro   Lys Ser Pro Gly Leu   Asn Arg Glu 
    12305                 12310                 12315             


Gln Leu   Tyr Trp Glu Leu Ser   Lys Leu Thr Asn Asp   Ile Glu Glu 
    12320                 12325                 12330             


Leu Gly   Pro Tyr Thr Leu Asp   Arg Asn Ser Leu Tyr   Val Asn Gly 
    12335                 12340                 12345             


Phe Thr   His Gln Ser Ser Val   Ser Thr Thr Ser Thr   Pro Gly Thr 
    12350                 12355                 12360             


Ser Thr   Val Asp Leu Arg Thr   Ser Gly Thr Pro Ser   Ser Leu Ser 
    12365                 12370                 12375             


Ser Pro   Thr Ile Met Ala Ala   Gly Pro Leu Leu Val   Pro Phe Thr 
    12380                 12385                 12390             


Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr Gly Glu   Asp Met Gly 
    12395                 12400                 12405             


His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln 
    12410                 12415                 12420             


Gly Leu   Leu Gly Pro Ile Phe   Lys Asn Thr Ser Val   Gly Pro Leu 
    12425                 12430                 12435             


Tyr Ser   Gly Cys Arg Leu Thr   Ser Leu Arg Ser Glu   Lys Asp Gly 
    12440                 12445                 12450             


Ala Ala   Thr Gly Val Asp Ala   Ile Cys Ile His His   Leu Asp Pro 
    12455                 12460                 12465             


Lys Ser   Pro Gly Leu Asn Arg   Glu Arg Leu Tyr Trp   Glu Leu Ser 
    12470                 12475                 12480             


Gln Leu   Thr Asn Gly Ile Lys   Glu Leu Gly Pro Tyr   Thr Leu Asp 
    12485                 12490                 12495             


Arg Asn   Ser Leu Tyr Val Asn   Gly Phe Thr His Arg   Thr Ser Val 
    12500                 12505                 12510             


Pro Thr   Thr Ser Thr Pro Gly   Thr Ser Thr Val Asp   Leu Gly Thr 
    12515                 12520                 12525             


Ser Gly   Thr Pro Phe Ser Leu   Pro Ser Pro Ala Thr   Ala Gly Pro 
    12530                 12535                 12540             


Leu Leu   Val Leu Phe Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Lys 
    12545                 12550                 12555             


Tyr Glu   Glu Asp Met His Arg   Pro Gly Ser Arg Lys   Phe Asn Thr 
    12560                 12565                 12570             


Thr Glu   Arg Val Leu Gln Thr   Leu Leu Gly Pro Met   Phe Lys Asn 
    12575                 12580                 12585             


Thr Ser   Val Gly Leu Leu Tyr   Ser Gly Cys Arg Leu   Thr Leu Leu 
    12590                 12595                 12600             


Arg Ser   Glu Lys Asp Gly Ala   Ala Thr Gly Val Asp   Ala Ile Cys 
    12605                 12610                 12615             


Thr His   Arg Leu Asp Pro Lys   Ser Pro Gly Leu Asp   Arg Glu Gln 
    12620                 12625                 12630             


Leu Tyr   Trp Glu Leu Ser Gln   Leu Thr Asn Gly Ile   Lys Glu Leu 
    12635                 12640                 12645             


Gly Pro   Tyr Thr Leu Asp Arg   Asn Ser Leu Tyr Val   Asn Gly Phe 
    12650                 12655                 12660             


Thr His   Trp Ile Pro Val Pro   Thr Ser Ser Thr Pro   Gly Thr Ser 
    12665                 12670                 12675             


Thr Val   Asp Leu Gly Ser Gly   Thr Pro Ser Ser Leu   Pro Ser Pro 
    12680                 12685                 12690             


Thr Ala   Ala Gly Pro Leu Leu   Val Pro Phe Thr Leu   Asn Phe Thr 
    12695                 12700                 12705             


Ile Thr   Asn Leu Gln Tyr Glu   Glu Asp Met His His   Pro Gly Ser 
    12710                 12715                 12720             


Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu Gln Gly   Leu Leu Gly 
    12725                 12730                 12735             


Pro Met   Phe Lys Asn Thr Ser   Val Gly Leu Leu Tyr   Ser Gly Cys 
    12740                 12745                 12750             


Arg Leu   Thr Leu Leu Arg Ser   Glu Lys Asp Gly Ala   Ala Thr Gly 
    12755                 12760                 12765             


Val Asp   Ala Ile Cys Thr His   Arg Leu Asp Pro Lys   Ser Pro Gly 
    12770                 12775                 12780             


Val Asp   Arg Glu Gln Leu Tyr   Trp Glu Leu Ser Gln   Leu Thr Asn 
    12785                 12790                 12795             


Gly Ile   Lys Glu Leu Gly Pro   Tyr Thr Leu Asp Arg   Asn Ser Leu 
    12800                 12805                 12810             


Tyr Val   Asn Gly Phe Thr His   Gln Thr Ser Ala Pro   Asn Thr Ser 
    12815                 12820                 12825             


Thr Pro   Gly Thr Ser Thr Val   Asp Leu Gly Thr Ser   Gly Thr Pro 
    12830                 12835                 12840             


Ser Ser   Leu Pro Ser Pro Thr   Ser Ala Gly Pro Leu   Leu Val Pro 
    12845                 12850                 12855             


Phe Thr   Leu Asn Phe Thr Ile   Thr Asn Leu Gln Tyr   Glu Glu Asp 
    12860                 12865                 12870             


Met Arg   His Pro Gly Ser Arg   Lys Phe Asn Thr Thr   Glu Arg Val 
    12875                 12880                 12885             


Leu Gln   Gly Leu Leu Lys Pro   Leu Phe Lys Ser Thr   Ser Val Gly 
    12890                 12895                 12900             


Pro Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu Leu Arg   Ser Glu Lys 
    12905                 12910                 12915             


Asp Gly   Ala Ala Thr Gly Val   Asp Ala Ile Cys Thr   His Arg Leu 
    12920                 12925                 12930             


Asp Pro   Lys Ser Pro Gly Val   Asp Arg Glu Gln Leu   Tyr Trp Glu 
    12935                 12940                 12945             


Leu Ser   Gln Leu Thr Asn Gly   Ile Lys Glu Leu Gly   Pro Tyr Thr 
    12950                 12955                 12960             


Leu Asp   Arg Asn Ser Leu Tyr   Val Asn Gly Phe Thr   His Gln Thr 
    12965                 12970                 12975             


Ser Ala   Pro Asn Thr Ser Thr   Pro Gly Thr Ser Thr   Val Asp Leu 
    12980                 12985                 12990             


Gly Thr   Ser Gly Thr Pro Ser   Ser Leu Pro Ser Pro   Thr Ser Ala 
    12995                 13000                 13005             


Gly Pro   Leu Leu Val Pro Phe   Thr Leu Asn Phe Thr   Ile Thr Asn 
    13010                 13015                 13020             


Leu Gln   Tyr Glu Glu Asp Met   His His Pro Gly Ser   Arg Lys Phe 
    13025                 13030                 13035             


Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu Leu Gly   Pro Met Phe 
    13040                 13045                 13050             


Lys Asn   Thr Ser Val Gly Leu   Leu Tyr Ser Gly Cys   Arg Leu Thr 
    13055                 13060                 13065             


Leu Leu   Arg Pro Glu Lys Asn   Gly Ala Ala Thr Gly   Met Asp Ala 
    13070                 13075                 13080             


Ile Cys   Ser His Arg Leu Asp   Pro Lys Ser Pro Gly   Leu Asn Arg 
    13085                 13090                 13095             


Glu Gln   Leu Tyr Trp Glu Leu   Ser Gln Leu Thr His   Gly Ile Lys 
    13100                 13105                 13110             


Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Asn Ser Leu   Tyr Val Asn 
    13115                 13120                 13125             


Gly Phe   Thr His Arg Ser Ser   Val Ala Pro Thr Ser   Thr Pro Gly 
    13130                 13135                 13140             


Thr Ser   Thr Val Asp Leu Gly   Thr Ser Gly Thr Pro   Ser Ser Leu 
    13145                 13150                 13155             


Pro Ser   Pro Thr Thr Ala Val   Pro Leu Leu Val Pro   Phe Thr Leu 
    13160                 13165                 13170             


Asn Phe   Thr Ile Thr Asn Leu   Gln Tyr Gly Glu Asp   Met Arg His 
    13175                 13180                 13185             


Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu Arg Val   Leu Gln Gly 
    13190                 13195                 13200             


Leu Leu   Gly Pro Leu Phe Lys   Asn Ser Ser Val Gly   Pro Leu Tyr 
    13205                 13210                 13215             


Ser Gly   Cys Arg Leu Ile Ser   Leu Arg Ser Glu Lys   Asp Gly Ala 
    13220                 13225                 13230             


Ala Thr   Gly Val Asp Ala Ile   Cys Thr His His Leu   Asn Pro Gln 
    13235                 13240                 13245             


Ser Pro   Gly Leu Asp Arg Glu   Gln Leu Tyr Trp Gln   Leu Ser Gln 
    13250                 13255                 13260             


Met Thr   Asn Gly Ile Lys Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    13265                 13270                 13275             


Asn Ser   Leu Tyr Val Asn Gly   Phe Thr His Arg Ser   Ser Gly Leu 
    13280                 13285                 13290             


Thr Thr   Ser Thr Pro Trp Thr   Ser Thr Val Asp Leu   Gly Thr Ser 
    13295                 13300                 13305             


Gly Thr   Pro Ser Pro Val Pro   Ser Pro Thr Thr Ala   Gly Pro Leu 
    13310                 13315                 13320             


Leu Val   Pro Phe Thr Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr 
    13325                 13330                 13335             


Glu Glu   Asp Met His Arg Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    13340                 13345                 13350             


Glu Arg   Val Leu Gln Gly Leu   Leu Ser Pro Ile Phe   Lys Asn Ser 
    13355                 13360                 13365             


Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg Leu Thr   Ser Leu Arg 
    13370                 13375                 13380             


Pro Glu   Lys Asp Gly Ala Ala   Thr Gly Met Asp Ala   Val Cys Leu 
    13385                 13390                 13395             


Tyr His   Pro Asn Pro Lys Arg   Pro Gly Leu Asp Arg   Glu Gln Leu 
    13400                 13405                 13410             


Tyr Trp   Glu Leu Ser Gln Leu   Thr His Asn Ile Thr   Glu Leu Gly 
    13415                 13420                 13425             


Pro Tyr   Ser Leu Asp Arg Asp   Ser Leu Tyr Val Asn   Gly Phe Thr 
    13430                 13435                 13440             


His Gln   Asn Ser Val Pro Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    13445                 13450                 13455             


Val Tyr   Trp Ala Thr Thr Gly   Thr Pro Ser Ser Phe   Pro Gly His 
    13460                 13465                 13470             


Thr Glu   Pro Gly Pro Leu Leu   Ile Pro Phe Thr Phe   Asn Phe Thr 
    13475                 13480                 13485             


Ile Thr   Asn Leu His Tyr Glu   Glu Asn Met Gln His   Pro Gly Ser 
    13490                 13495                 13500             


Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu Gln Gly   Leu Leu Lys 
    13505                 13510                 13515             


Pro Leu   Phe Lys Asn Thr Ser   Val Gly Pro Leu Tyr   Ser Gly Cys 
    13520                 13525                 13530             


Arg Leu   Thr Ser Leu Arg Pro   Glu Lys Asp Gly Ala   Ala Thr Gly 
    13535                 13540                 13545             


Met Asp   Ala Val Cys Leu Tyr   His Pro Asn Pro Lys   Arg Pro Gly 
    13550                 13555                 13560             


Leu Asp   Arg Glu Gln Leu Tyr   Trp Glu Leu Ser Gln   Leu Thr His 
    13565                 13570                 13575             


Asn Ile   Thr Glu Leu Gly Pro   Tyr Ser Leu Asp Arg   Asp Ser Leu 
    13580                 13585                 13590             


Tyr Val   Asn Gly Phe Thr His   Gln Asn Ser Val Pro   Thr Thr Ser 
    13595                 13600                 13605             


Thr Pro   Gly Thr Ser Thr Val   Tyr Trp Ala Thr Thr   Gly Thr Pro 
    13610                 13615                 13620             


Ser Ser   Phe Pro Gly His Thr   Glu Pro Gly Pro Leu   Leu Ile Pro 
    13625                 13630                 13635             


Phe Thr   Phe Asn Phe Thr Ile   Thr Asn Leu His Tyr   Glu Glu Asn 
    13640                 13645                 13650             


Met Gln   His Pro Gly Ser Arg   Lys Phe Asn Thr Thr   Glu Arg Val 
    13655                 13660                 13665             


Leu Gln   Gly Leu Leu Lys Pro   Leu Phe Lys Asn Thr   Ser Val Gly 
    13670                 13675                 13680             


Pro Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu Leu Arg   Pro Glu Lys 
    13685                 13690                 13695             


His Glu   Ala Ala Thr Gly Val   Asp Thr Ile Cys Thr   His Arg Val 
    13700                 13705                 13710             


Asp Pro   Ile Gly Pro Gly Leu   Asp Arg Glu Arg Leu   Tyr Trp Glu 
    13715                 13720                 13725             


Leu Ser   Gln Leu Thr Asn Ser   Ile Thr Glu Leu Gly   Pro Tyr Thr 
    13730                 13735                 13740             


Leu Asp   Arg Asp Ser Leu Tyr   Val Asn Gly Phe Asn   Pro Arg Ser 
    13745                 13750                 13755             


Ser Val   Pro Thr Thr Ser Thr   Pro Gly Thr Ser Thr   Val His Leu 
    13760                 13765                 13770             


Ala Thr   Ser Gly Thr Pro Ser   Ser Leu Pro Gly His   Thr Ala Pro 
    13775                 13780                 13785             


Val Pro   Leu Leu Ile Pro Phe   Thr Leu Asn Phe Thr   Ile Thr Asn 
    13790                 13795                 13800             


Leu His   Tyr Glu Glu Asn Met   Gln His Pro Gly Ser   Arg Lys Phe 
    13805                 13810                 13815             


Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu Leu Lys   Pro Leu Phe 
    13820                 13825                 13830             


Lys Asn   Thr Ser Val Gly Pro   Leu Tyr Ser Gly Cys   Arg Leu Thr 
    13835                 13840                 13845             


Leu Leu   Arg Pro Glu Lys His   Glu Ala Ala Thr Gly   Val Asp Thr 
    13850                 13855                 13860             


Ile Cys   Thr His Arg Val Asp   Pro Ile Gly Pro Gly   Leu Xaa Xaa 
    13865                 13870                 13875             


Glu Xaa   Leu Tyr Trp Glu Leu   Ser Xaa Leu Thr Xaa   Xaa Ile Xaa 
    13880                 13885                 13890             


Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Xaa Ser Leu   Tyr Val Asn 
    13895                 13900                 13905             


Gly Phe   Thr His Xaa Xaa Ser   Xaa Pro Thr Thr Ser   Thr Pro Gly 
    13910                 13915                 13920             


Thr Ser   Thr Val Xaa Xaa Gly   Thr Ser Gly Thr Pro   Ser Ser Xaa 
    13925                 13930                 13935             


Pro Xaa   Xaa Thr Ser Ala Gly   Pro Leu Leu Val Pro   Phe Thr Leu 
    13940                 13945                 13950             


Asn Phe   Thr Ile Thr Asn Leu   Gln Tyr Glu Glu Asp   Met His His 
    13955                 13960                 13965             


Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu Arg Val   Leu Gln Gly 
    13970                 13975                 13980             


Leu Leu   Gly Pro Met Phe Lys   Asn Thr Ser Val Gly   Leu Leu Tyr 
    13985                 13990                 13995             


Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Pro Glu Lys   Asn Gly Ala 
    14000                 14005                 14010             


Ala Thr   Gly Met Asp Ala Ile   Cys Ser His Arg Leu   Asp Pro Lys 
    14015                 14020                 14025             


Ser Pro   Gly Leu Asp Arg Glu   Gln Leu Tyr Trp Glu   Leu Ser Gln 
    14030                 14035                 14040             


Leu Thr   His Gly Ile Lys Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    14045                 14050                 14055             


Asn Ser   Leu Tyr Val Asn Gly   Phe Thr His Arg Ser   Ser Val Ala 
    14060                 14065                 14070             


Pro Thr   Ser Thr Pro Gly Thr   Ser Thr Val Asp Leu   Gly Thr Ser 
    14075                 14080                 14085             


Gly Thr   Pro Ser Ser Leu Pro   Ser Pro Thr Thr Ala   Val Pro Leu 
    14090                 14095                 14100             


Leu Val   Pro Phe Thr Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr 
    14105                 14110                 14115             


Gly Glu   Asp Met Arg His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    14120                 14125                 14130             


Glu Arg   Val Leu Gln Gly Leu   Leu Gly Pro Leu Phe   Lys Asn Ser 
    14135                 14140                 14145             


Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg Leu Ile   Ser Leu Arg 
    14150                 14155                 14160             


Ser Glu   Lys Asp Gly Ala Ala   Thr Gly Val Asp Ala   Ile Cys Thr 
    14165                 14170                 14175             


His His   Leu Asn Pro Gln Ser   Pro Gly Leu Asp Arg   Glu Gln Leu 
    14180                 14185                 14190             


Tyr Trp   Gln Leu Ser Gln Met   Thr Asn Gly Ile Lys   Glu Leu Gly 
    14195                 14200                 14205             


Pro Tyr   Thr Leu Asp Arg Asn   Ser Leu Tyr Val Asn   Gly Phe Thr 
    14210                 14215                 14220             


His Arg   Ser Ser Gly Leu Thr   Thr Ser Thr Pro Trp   Thr Ser Thr 
    14225                 14230                 14235             


Val Asp   Leu Gly Thr Ser Gly   Thr Pro Ser Pro Val   Pro Ser Pro 
    14240                 14245                 14250             


Thr Thr   Ala Gly Pro Leu Leu   Val Pro Phe Thr Leu   Asn Phe Thr 
    14255                 14260                 14265             


Ile Thr   Asn Leu Gln Tyr Glu   Glu Asp Met His Arg   Pro Gly Ser 
    14270                 14275                 14280             


Arg Lys   Phe Asn Ala Thr Glu   Arg Val Leu Gln Gly   Leu Leu Ser 
    14285                 14290                 14295             


Pro Ile   Phe Lys Asn Ser Ser   Val Gly Pro Leu Tyr   Ser Gly Cys 
    14300                 14305                 14310             


Arg Leu   Thr Ser Leu Arg Pro   Glu Lys Asp Gly Ala   Ala Thr Gly 
    14315                 14320                 14325             


Met Asp   Ala Val Cys Leu Tyr   His Pro Asn Pro Lys   Arg Pro Gly 
    14330                 14335                 14340             


Leu Asp   Arg Glu Gln Leu Tyr   Trp Glu Leu Ser Gln   Leu Thr His 
    14345                 14350                 14355             


Asn Ile   Thr Glu Leu Gly Pro   Tyr Ser Leu Asp Arg   Asp Ser Leu 
    14360                 14365                 14370             


Tyr Val   Asn Gly Phe Thr His   Gln Ser Ser Met Thr   Thr Thr Arg 
    14375                 14380                 14385             


Thr Pro   Asp Thr Ser Thr Met   His Leu Ala Thr Ser   Arg Thr Pro 
    14390                 14395                 14400             


Ala Ser   Leu Ser Gly Pro Thr   Thr Ala Ser Pro Leu   Leu Val Leu 
    14405                 14410                 14415             


Phe Thr   Ile Asn Cys Thr Ile   Thr Asn Leu Gln Tyr   Glu Glu Asp 
    14420                 14425                 14430             


Met Arg   Arg Thr Gly Ser Arg   Lys Phe Asn Thr Met   Glu Ser Val 
    14435                 14440                 14445             


Leu Gln   Gly Leu Leu Lys Pro   Leu Phe Lys Asn Thr   Ser Val Gly 
    14450                 14455                 14460             


Pro Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu Leu Arg   Pro Lys Lys 
    14465                 14470                 14475             


Asp Gly   Ala Ala Thr Gly Val   Asp Ala Ile Cys Thr   His Arg Leu 
    14480                 14485                 14490             


Asp Pro   Lys Ser Pro Gly Leu   Asn Arg Glu Gln Leu   Tyr Trp Glu 
    14495                 14500                 14505             


Leu Ser   Lys Leu Thr Asn Asp   Ile Glu Glu Leu Gly   Pro Tyr Thr 
    14510                 14515                 14520             


Leu Asp   Arg Asn Ser Leu Tyr   Val Asn Gly Phe Thr   His Gln Ser 
    14525                 14530                 14535             


Ser Val   Ser Thr Thr Ser Thr   Pro Gly Thr Ser Thr   Val Asp Leu 
    14540                 14545                 14550             


Arg Thr   Ser Gly Thr Pro Ser   Ser Leu Ser Ser Pro   Thr Ile Met 
    14555                 14560                 14565             


Xaa Xaa   Xaa Pro Leu Leu Xaa   Pro Phe Thr Xaa Asn   Xaa Thr Ile 
    14570                 14575                 14580             


Thr Asn   Leu Xaa Xaa Xaa Xaa   Xaa Met Xaa Xaa Pro   Gly Ser Arg 
    14585                 14590                 14595             


Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln Gly Leu   Leu Arg Pro 
    14600                 14605                 14610             


Leu Phe   Lys Asn Thr Ser Val   Ser Ser Leu Tyr Ser   Gly Cys Arg 
    14615                 14620                 14625             


Leu Thr   Leu Leu Arg Pro Glu   Lys Asp Gly Ala Ala   Thr Arg Val 
    14630                 14635                 14640             


Asp Ala   Ala Cys Thr Tyr Arg   Pro Asp Pro Lys Ser   Pro Gly Leu 
    14645                 14650                 14655             


Asp Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser Gln Leu   Thr His Ser 
    14660                 14665                 14670             


Ile Thr   Glu Leu Gly Pro Tyr   Thr Leu Asp Arg Val   Ser Leu Tyr 
    14675                 14680                 14685             


Val Asn   Gly Phe Asn Pro Arg   Ser Ser Val Pro Thr   Thr Ser Thr 
    14690                 14695                 14700             


Pro Gly   Thr Ser Thr Val His   Leu Ala Thr Ser Gly   Thr Pro Ser 
    14705                 14710                 14715             


Ser Leu   Pro Gly His Thr Xaa   Xaa Xaa Pro Leu Leu   Xaa Pro Phe 
    14720                 14725                 14730             


Thr Xaa   Asn Xaa Thr Ile Thr   Asn Leu Xaa Xaa Xaa   Xaa Xaa Met 
    14735                 14740                 14745             


Xaa Xaa   Pro Gly Ser Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu 
    14750                 14755                 14760             


Gln Gly   Leu Leu Lys Pro Leu   Phe Arg Asn Ser Ser   Leu Glu Tyr 
    14765                 14770                 14775             


Leu Tyr   Ser Gly Cys Arg Leu   Ala Ser Leu Arg Pro   Glu Lys Asp 
    14780                 14785                 14790             


Ser Ser   Ala Met Ala Val Asp   Ala Ile Cys Thr His   Arg Pro Asp 
    14795                 14800                 14805             


Pro Glu   Asp Leu Gly Leu Asp   Arg Glu Arg Leu Tyr   Trp Glu Leu 
    14810                 14815                 14820             


Ser Asn   Leu Thr Asn Gly Ile   Gln Glu Leu Gly Pro   Tyr Thr Leu 
    14825                 14830                 14835             


Asp Arg   Asn Ser Leu Tyr Val   Asn Gly Phe Thr His   Arg Ser Ser 
    14840                 14845                 14850             


Gly Leu   Thr Thr Ser Thr Pro   Trp Thr Ser Thr Val   Asp Leu Gly 
    14855                 14860                 14865             


Thr Ser   Gly Thr Pro Ser Pro   Val Pro Ser Pro Thr   Thr Ala Gly 
    14870                 14875                 14880             


Pro Leu   Leu Val Pro Phe Thr   Leu Asn Phe Thr Ile   Thr Asn Leu 
    14885                 14890                 14895             


Gln Tyr   Glu Glu Asp Met His   Arg Pro Gly Ser Arg   Arg Phe Asn 
    14900                 14905                 14910             


Thr Thr   Glu Arg Val Leu Gln   Gly Leu Leu Thr Pro   Leu Phe Lys 
    14915                 14920                 14925             


Asn Thr   Ser Val Gly Pro Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu 
    14930                 14935                 14940             


Leu Arg   Pro Glu Lys Gln Glu   Ala Ala Thr Gly Val   Asp Thr Ile 
    14945                 14950                 14955             


Cys Thr   His Arg Val Asp Pro   Ile Gly Pro Gly Leu   Asp Arg Glu 
    14960                 14965                 14970             


Arg Leu   Tyr Trp Glu Leu Ser   Gln Leu Thr Asn Ser   Ile Thr Glu 
    14975                 14980                 14985             


Leu Gly   Pro Tyr Thr Leu Asp   Arg Asp Ser Leu Tyr   Val Asn Gly 
    14990                 14995                 15000             


Phe Asn   Pro Trp Ser Ser Val   Pro Thr Thr Ser Thr   Pro Gly Thr 
    15005                 15010                 15015             


Ser Thr   Val His Leu Ala Thr   Ser Gly Thr Pro Ser   Ser Leu Pro 
    15020                 15025                 15030             


Gly His   Thr Ala Pro Val Pro   Leu Leu Ile Pro Phe   Thr Leu Asn 
    15035                 15040                 15045             


Phe Thr   Ile Thr Asp Leu His   Tyr Glu Glu Asn Met   Gln His Pro 
    15050                 15055                 15060             


Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu 
    15065                 15070                 15075             


Leu Lys   Pro Leu Phe Lys Ser   Thr Ser Val Gly Pro   Leu Tyr Ser 
    15080                 15085                 15090             


Gly Cys   Arg Leu Thr Leu Leu   Arg Pro Glu Lys His   Gly Ala Ala 
    15095                 15100                 15105             


Thr Gly   Val Asp Ala Ile Cys   Thr Leu Arg Leu Asp   Pro Thr Gly 
    15110                 15115                 15120             


Pro Gly   Leu Asp Arg Glu Arg   Leu Tyr Trp Glu Leu   Ser Gln Leu 
    15125                 15130                 15135             


Thr Asn   Ser Val Thr Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Asp 
    15140                 15145                 15150             


Ser Leu   Tyr Val Asn Gly Phe   Thr His Arg Ser Ser   Val Pro Thr 
    15155                 15160                 15165             


Thr Ser   Ile Pro Gly Thr Ser   Ala Val His Leu Glu   Thr Ser Gly 
    15170                 15175                 15180             


Thr Pro   Ala Ser Leu Pro Gly   His Thr Ala Pro Gly   Pro Leu Leu 
    15185                 15190                 15195             


Val Pro   Phe Thr Leu Asn Phe   Thr Ile Thr Asn Leu   Gln Tyr Glu 
    15200                 15205                 15210             


Glu Asp   Met Arg His Pro Gly   Ser Arg Lys Phe Ser   Thr Thr Glu 
    15215                 15220                 15225             


Arg Val   Leu Gln Gly Leu Leu   Lys Pro Leu Phe Lys   Asn Thr Ser 
    15230                 15235                 15240             


Val Ser   Ser Leu Tyr Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Pro 
    15245                 15250                 15255             


Glu Lys   Asp Gly Ala Ala Thr   Arg Val Asp Ala Val   Cys Thr His 
    15260                 15265                 15270             


Arg Pro   Asp Pro Lys Ser Pro   Gly Leu Asp Arg Glu   Arg Leu Tyr 
    15275                 15280                 15285             


Trp Lys   Leu Ser Gln Leu Thr   His Gly Ile Thr Glu   Leu Gly Pro 
    15290                 15295                 15300             


Tyr Thr   Leu Asp Arg His Ser   Leu Tyr Val Asn Gly   Phe Thr His 
    15305                 15310                 15315             


Gln Ser   Ser Met Thr Thr Thr   Arg Thr Pro Asp Thr   Ser Thr Met 
    15320                 15325                 15330             


His Leu   Ala Thr Ser Arg Thr   Pro Ala Ser Leu Ser   Gly Pro Thr 
    15335                 15340                 15345             


Thr Ala   Ser Pro Leu Leu Val   Leu Phe Thr Ile Asn   Phe Thr Ile 
    15350                 15355                 15360             


Thr Asn   Leu Arg Tyr Glu Glu   Asn Met His His Pro   Gly Ser Arg 
    15365                 15370                 15375             


Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln Gly Leu   Leu Arg Pro 
    15380                 15385                 15390             


Val Phe   Lys Asn Thr Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg 
    15395                 15400                 15405             


Leu Thr   Thr Leu Arg Pro Lys   Lys Asp Gly Ala Ala   Thr Lys Val 
    15410                 15415                 15420             


Asp Ala   Ile Cys Thr Tyr Arg   Pro Asp Pro Lys Ser   Pro Gly Leu 
    15425                 15430                 15435             


Asp Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser Gln Leu   Thr His Ser 
    15440                 15445                 15450             


Ile Thr   Glu Leu Gly Pro Tyr   Thr Gln Asp Arg Asp   Ser Leu Tyr 
    15455                 15460                 15465             


Val Asn   Gly Phe Thr His Arg   Ser Ser Val Pro Thr   Thr Ser Ile 
    15470                 15475                 15480             


Pro Gly   Thr Ser Ala Val His   Leu Glu Thr Ser Gly   Thr Pro Ala 
    15485                 15490                 15495             


Ser Leu   Pro Gly His Thr Ala   Pro Gly Pro Leu Leu   Val Pro Phe 
    15500                 15505                 15510             


Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Gln Tyr Glu   Glu Asp Met 
    15515                 15520                 15525             


Arg His   Pro Gly Ser Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu 
    15530                 15535                 15540             


Gln Gly   Leu Leu Lys Pro Leu   Phe Lys Ser Thr Ser   Val Gly Pro 
    15545                 15550                 15555             


Leu Tyr   Ser Gly Cys Arg Leu   Thr Leu Leu Arg Pro   Glu Lys Arg 
    15560                 15565                 15570             


Gly Ala   Ala Thr Gly Val Asp   Thr Ile Cys Thr His   Arg Leu Asp 
    15575                 15580                 15585             


Pro Leu   Asn Pro Gly Leu Asp   Arg Glu Gln Leu Tyr   Trp Glu Leu 
    15590                 15595                 15600             


Ser Lys   Leu Thr Arg Gly Ile   Ile Glu Leu Gly Pro   Tyr Leu Leu 
    15605                 15610                 15615             


Asp Arg   Gly Ser Leu Tyr Val   Asn Gly Phe Thr His   Arg Thr Ser 
    15620                 15625                 15630             


Val Pro   Thr Thr Ser Thr Pro   Gly Thr Ser Thr Val   Asp Leu Gly 
    15635                 15640                 15645             


Thr Ser   Gly Thr Pro Phe Ser   Leu Pro Ser Pro Ala   Xaa Xaa Xaa 
    15650                 15655                 15660             


Pro Leu   Leu Xaa Pro Phe Thr   Xaa Asn Xaa Thr Ile   Thr Asn Leu 
    15665                 15670                 15675             


Xaa Xaa   Xaa Xaa Xaa Met Xaa   Xaa Pro Gly Ser Arg   Lys Phe Asn 
    15680                 15685                 15690             


Thr Thr   Glu Arg Val Leu Gln   Thr Leu Leu Gly Pro   Met Phe Lys 
    15695                 15700                 15705             


Asn Thr   Ser Val Gly Leu Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu 
    15710                 15715                 15720             


Leu Arg   Ser Glu Lys Asp Gly   Ala Ala Thr Gly Val   Asp Ala Ile 
    15725                 15730                 15735             


Cys Thr   His Arg Leu Asp Pro   Lys Ser Pro Gly Val   Asp Arg Glu 
    15740                 15745                 15750             


Gln Leu   Tyr Trp Glu Leu Ser   Gln Leu Thr Asn Gly   Ile Lys Glu 
    15755                 15760                 15765             


Leu Gly   Pro Tyr Thr Leu Asp   Arg Asn Ser Leu Tyr   Val Asn Gly 
    15770                 15775                 15780             


Phe Thr   His Trp Ile Pro Val   Pro Thr Ser Ser Thr   Pro Gly Thr 
    15785                 15790                 15795             


Ser Thr   Val Asp Leu Gly Ser   Gly Thr Pro Ser Ser   Leu Pro Ser 
    15800                 15805                 15810             


Pro Thr   Thr Ala Gly Pro Leu   Leu Val Pro Phe Thr   Leu Asn Phe 
    15815                 15820                 15825             


Thr Ile   Thr Asn Leu Lys Tyr   Glu Glu Asp Met His   Cys Pro Gly 
    15830                 15835                 15840             


Ser Arg   Lys Phe Asn Thr Thr   Glu Arg Val Leu Gln   Ser Leu Leu 
    15845                 15850                 15855             


Gly Pro   Met Phe Lys Asn Thr   Ser Val Gly Pro Leu   Tyr Ser Gly 
    15860                 15865                 15870             


Cys Arg   Leu Thr Leu Leu Arg   Ser Glu Lys Asp Gly   Ala Ala Thr 
    15875                 15880                 15885             


Gly Val   Asp Ala Ile Cys Thr   His Arg Leu Asp Pro   Lys Ser Pro 
    15890                 15895                 15900             


Gly Val   Asp Arg Glu Gln Leu   Tyr Trp Glu Leu Ser   Gln Leu Thr 
    15905                 15910                 15915             


Asn Gly   Ile Lys Glu Leu Gly   Pro Tyr Thr Leu Asp   Arg Asn Ser 
    15920                 15925                 15930             


Leu Tyr   Val Asn Gly Phe Thr   His Gln Thr Ser Ala   Pro Asn Thr 
    15935                 15940                 15945             


Ser Thr   Pro Gly Thr Ser Thr   Val Asp Leu Gly Thr   Ser Gly Thr 
    15950                 15955                 15960             


Pro Ser   Ser Leu Pro Ser Pro   Thr Xaa Xaa Xaa Pro   Leu Leu Xaa 
    15965                 15970                 15975             


Pro Phe   Thr Xaa Asn Xaa Thr   Ile Thr Asn Leu Xaa   Xaa Xaa Xaa 
    15980                 15985                 15990             


Xaa Met   Xaa Xaa Pro Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Xaa 
    15995                 16000                 16005             


Val Leu   Gln Gly Leu Leu Xaa   Pro Xaa Phe Lys Asn   Xaa Ser Val 
    16010                 16015                 16020             


Gly Xaa   Leu Tyr Ser Gly Cys   Arg Leu Thr Xaa Leu   Arg Xaa Glu 
    16025                 16030                 16035             


Lys Xaa   Gly Ala Ala Thr Gly   Xaa Asp Ala Ile Cys   Xaa His Xaa 
    16040                 16045                 16050             


Xaa Xaa   Pro Lys Xaa Pro Gly   Leu Xaa Xaa Glu Xaa   Leu Tyr Trp 
    16055                 16060                 16065             


Glu Leu   Ser Xaa Leu Thr Xaa   Xaa Ile Xaa Glu Leu   Gly Pro Tyr 
    16070                 16075                 16080             


Thr Leu   Asp Arg Xaa Ser Leu   Tyr Val Asn Gly Phe   Thr His Trp 
    16085                 16090                 16095             


Ile Pro   Val Pro Thr Ser Ser   Thr Pro Gly Thr Ser   Thr Val Asp 
    16100                 16105                 16110             


Leu Gly   Ser Gly Thr Pro Ser   Ser Leu Pro Ser Pro   Thr Thr Ala 
    16115                 16120                 16125             


Gly Pro   Leu Leu Val Pro Phe   Thr Leu Asn Phe Thr   Ile Thr Asn 
    16130                 16135                 16140             


Leu Lys   Tyr Glu Glu Asp Met   His Cys Pro Gly Ser   Arg Lys Phe 
    16145                 16150                 16155             


Asn Thr   Thr Glu Arg Val Leu   Gln Ser Leu Leu Gly   Pro Met Phe 
    16160                 16165                 16170             


Lys Asn   Thr Ser Val Gly Pro   Leu Tyr Ser Gly Cys   Arg Leu Thr 
    16175                 16180                 16185             


Ser Leu   Arg Ser Glu Lys Asp   Gly Ala Ala Thr Gly   Val Asp Ala 
    16190                 16195                 16200             


Ile Cys   Thr His Arg Val Asp   Pro Lys Ser Pro Gly   Val Asp Arg 
    16205                 16210                 16215             


Glu Gln   Leu Tyr Trp Glu Leu   Ser Gln Leu Thr Asn   Gly Ile Lys 
    16220                 16225                 16230             


Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Asn Ser Leu   Tyr Val Asn 
    16235                 16240                 16245             


Gly Phe   Thr His Gln Thr Ser   Ala Pro Asn Thr Ser   Thr Pro Gly 
    16250                 16255                 16260             


Thr Ser   Thr Val Xaa Xaa Gly   Thr Ser Gly Thr Pro   Ser Ser Xaa 
    16265                 16270                 16275             


Pro Xaa   Xaa Thr Ser Ala Gly   Pro Leu Leu Val Pro   Phe Thr Leu 
    16280                 16285                 16290             


Asn Phe   Thr Ile Thr Asn Leu   Gln Tyr Glu Glu Asp   Met His His 
    16295                 16300                 16305             


Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu Arg Val   Leu Gln Gly 
    16310                 16315                 16320             


Leu Leu   Gly Pro Met Phe Lys   Asn Thr Ser Val Gly   Leu Leu Tyr 
    16325                 16330                 16335             


Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Pro Glu Lys   Asn Gly Ala 
    16340                 16345                 16350             


Thr Thr   Gly Met Asp Ala Ile   Cys Thr His Arg Leu   Asp Pro Lys 
    16355                 16360                 16365             


Ser Pro   Gly Leu Xaa Xaa Glu   Xaa Leu Tyr Trp Glu   Leu Ser Xaa 
    16370                 16375                 16380             


Leu Thr   Xaa Xaa Ile Xaa Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    16385                 16390                 16395             


Xaa Ser   Leu Tyr Val Asn Gly   Phe Thr His Xaa Xaa   Ser Xaa Pro 
    16400                 16405                 16410             


Thr Thr   Ser Thr Pro Gly Thr   Ser Thr Val Xaa Xaa   Gly Thr Ser 
    16415                 16420                 16425             


Gly Thr   Pro Ser Ser Xaa Pro   Xaa Xaa Thr Xaa Xaa   Xaa Pro Leu 
    16430                 16435                 16440             


Leu Xaa   Pro Phe Thr Xaa Asn   Xaa Thr Ile Thr Asn   Leu Xaa Xaa 
    16445                 16450                 16455             


Xaa Xaa   Xaa Met Xaa Xaa Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    16460                 16465                 16470             


Glu Arg   Val Leu Gln Gly Leu   Leu Lys Pro Leu Phe   Arg Asn Ser 
    16475                 16480                 16485             


Ser Leu   Glu Tyr Leu Tyr Ser   Gly Cys Arg Leu Ala   Ser Leu Arg 
    16490                 16495                 16500             


Pro Glu   Lys Asp Ser Ser Ala   Met Ala Val Asp Ala   Ile Cys Thr 
    16505                 16510                 16515             


His Arg   Pro Asp Pro Glu Asp   Leu Gly Leu Asp Arg   Glu Arg Leu 
    16520                 16525                 16530             


Tyr Trp   Glu Leu Ser Asn Leu   Thr Asn Gly Ile Gln   Glu Leu Gly 
    16535                 16540                 16545             


Pro Tyr   Thr Leu Asp Arg Asn   Ser Leu Tyr Val Asn   Gly Phe Thr 
    16550                 16555                 16560             


His Arg   Ser Ser Met Pro Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    16565                 16570                 16575             


Val Asp   Val Gly Thr Ser Gly   Thr Pro Ser Ser Ser   Pro Ser Pro 
    16580                 16585                 16590             


Thr Thr   Ala Gly Pro Leu Leu   Ile Pro Phe Thr Leu   Asn Phe Thr 
    16595                 16600                 16605             


Ile Thr   Asn Leu Gln Tyr Gly   Glu Asp Met Gly His   Pro Gly Ser 
    16610                 16615                 16620             


Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu Gln Gly   Leu Leu Gly 
    16625                 16630                 16635             


Pro Ile   Phe Lys Asn Thr Ser   Val Gly Pro Leu Tyr   Ser Gly Cys 
    16640                 16645                 16650             


Arg Leu   Thr Ser Leu Arg Ser   Glu Lys Asp Gly Ala   Ala Thr Gly 
    16655                 16660                 16665             


Val Asp   Ala Ile Cys Ile His   His Leu Asp Pro Lys   Ser Pro Gly 
    16670                 16675                 16680             


Leu Asn   Arg Glu Arg Leu Tyr   Trp Glu Leu Ser Gln   Leu Thr Asn 
    16685                 16690                 16695             


Gly Ile   Lys Glu Leu Gly Pro   Tyr Thr Leu Asp Arg   Asn Ser Leu 
    16700                 16705                 16710             


Tyr Val   Asn Gly Phe Thr His   Arg Thr Ser Val Pro   Thr Thr Ser 
    16715                 16720                 16725             


Thr Pro   Gly Thr Ser Thr Val   Asp Leu Gly Thr Ser   Gly Thr Pro 
    16730                 16735                 16740             


Phe Ser   Leu Pro Ser Pro Ala   Thr Ala Gly Pro Leu   Leu Val Leu 
    16745                 16750                 16755             


Phe Thr   Leu Asn Phe Thr Ile   Thr Asn Leu Lys Tyr   Glu Glu Asp 
    16760                 16765                 16770             


Met His   Arg Pro Gly Ser Arg   Lys Phe Asn Thr Thr   Glu Arg Val 
    16775                 16780                 16785             


Leu Gln   Thr Leu Leu Gly Pro   Met Phe Lys Asn Thr   Ser Val Gly 
    16790                 16795                 16800             


Leu Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu Leu Arg   Ser Glu Lys 
    16805                 16810                 16815             


Asp Gly   Ala Ala Thr Gly Val   Asp Ala Ile Cys Thr   His Arg Leu 
    16820                 16825                 16830             


Asp Pro   Lys Ser Pro Gly Leu   Xaa Xaa Glu Xaa Leu   Tyr Trp Glu 
    16835                 16840                 16845             


Leu Ser   Xaa Leu Thr Xaa Xaa   Ile Xaa Glu Leu Gly   Pro Tyr Thr 
    16850                 16855                 16860             


Leu Asp   Arg Xaa Ser Leu Tyr   Val Asn Gly Phe Thr   His Xaa Xaa 
    16865                 16870                 16875             


Ser Xaa   Pro Thr Thr Ser Thr   Pro Gly Thr Ser Thr   Val Xaa Xaa 
    16880                 16885                 16890             


Gly Thr   Ser Gly Thr Pro Ser   Ser Xaa Pro Xaa Xaa   Thr Xaa Xaa 
    16895                 16900                 16905             


Xaa Pro   Leu Leu Xaa Pro Phe   Thr Xaa Asn Xaa Thr   Ile Thr Asn 
    16910                 16915                 16920             


Leu Xaa   Xaa Xaa Xaa Xaa Met   Xaa Xaa Pro Gly Ser   Arg Lys Phe 
    16925                 16930                 16935             


Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu Leu Arg   Pro Val Phe 
    16940                 16945                 16950             


Lys Asn   Thr Ser Val Gly Pro   Leu Tyr Ser Gly Cys   Arg Leu Thr 
    16955                 16960                 16965             


Leu Leu   Arg Pro Lys Lys Asp   Gly Ala Ala Thr Lys   Val Asp Ala 
    16970                 16975                 16980             


Ile Cys   Thr Tyr Arg Pro Asp   Pro Lys Ser Pro Gly   Leu Asp Arg 
    16985                 16990                 16995             


Glu Gln   Leu Tyr Trp Glu Leu   Ser Gln Leu Thr His   Ser Ile Thr 
    17000                 17005                 17010             


Glu Leu   Gly Pro Tyr Thr Gln   Asp Arg Asp Ser Leu   Tyr Val Asn 
    17015                 17020                 17025             


Gly Phe   Thr His Arg Ser Ser   Val Pro Thr Thr Ser   Ile Pro Gly 
    17030                 17035                 17040             


Thr Ser   Ala Val His Leu Glu   Thr Thr Gly Thr Pro   Ser Ser Phe 
    17045                 17050                 17055             


Pro Gly   His Thr Glu Pro Gly   Pro Leu Leu Ile Pro   Phe Thr Phe 
    17060                 17065                 17070             


Asn Phe   Thr Ile Thr Asn Leu   Arg Tyr Glu Glu Asn   Met Gln His 
    17075                 17080                 17085             


Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu Arg Val   Leu Gln Gly 
    17090                 17095                 17100             


Leu Leu   Thr Pro Leu Phe Lys   Asn Thr Ser Val Gly   Pro Leu Tyr 
    17105                 17110                 17115             


Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Pro Glu Lys   Gln Glu Ala 
    17120                 17125                 17130             


Ala Thr   Gly Val Asp Thr Ile   Cys Thr His Arg Val   Asp Pro Ile 
    17135                 17140                 17145             


Gly Pro   Gly Leu Asp Arg Glu   Arg Leu Tyr Trp Glu   Leu Ser Gln 
    17150                 17155                 17160             


Leu Thr   Asn Ser Ile Thr Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    17165                 17170                 17175             


Asp Ser   Leu Tyr Val Asp Gly   Phe Asn Pro Trp Ser   Ser Val Pro 
    17180                 17185                 17190             


Thr Thr   Ser Thr Pro Gly Thr   Ser Thr Val His Leu   Ala Thr Ser 
    17195                 17200                 17205             


Gly Thr   Pro Ser Pro Leu Pro   Gly His Thr Ala Pro   Val Pro Leu 
    17210                 17215                 17220             


Leu Ile   Pro Phe Thr Leu Asn   Phe Thr Ile Thr Asp   Leu His Tyr 
    17225                 17230                 17235             


Glu Glu   Asn Met Gln His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    17240                 17245                 17250             


Glu Arg   Val Leu Gln Gly Leu   Leu Lys Pro Leu Phe   Lys Ser Thr 
    17255                 17260                 17265             


Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg 
    17270                 17275                 17280             


Pro Glu   Lys His Gly Ala Ala   Thr Gly Val Asp Ala   Ile Cys Thr 
    17285                 17290                 17295             


Leu Arg   Leu Asp Pro Thr Gly   Pro Gly Leu Asp Arg   Glu Arg Leu 
    17300                 17305                 17310             


Tyr Trp   Glu Leu Ser Gln Leu   Thr Asn Ser Ile Thr   Glu Leu Gly 
    17315                 17320                 17325             


Pro Tyr   Thr Leu Asp Arg Asp   Ser Leu Tyr Val Asn   Gly Phe Asn 
    17330                 17335                 17340             


Pro Trp   Ser Ser Val Pro Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    17345                 17350                 17355             


Val His   Leu Ala Thr Ser Gly   Thr Pro Ser Ser Leu   Pro Gly His 
    17360                 17365                 17370             


Thr Thr   Ala Gly Pro Leu Leu   Val Pro Phe Thr Leu   Asn Phe Thr 
    17375                 17380                 17385             


Ile Thr   Asn Leu Lys Tyr Glu   Glu Asp Met His Cys   Pro Gly Ser 
    17390                 17395                 17400             


Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu Gln Ser   Leu His Gly 
    17405                 17410                 17415             


Pro Met   Phe Lys Asn Thr Ser   Val Gly Pro Leu Tyr   Ser Gly Cys 
    17420                 17425                 17430             


Arg Leu   Thr Leu Leu Arg Ser   Glu Lys Asp Gly Ala   Ala Thr Gly 
    17435                 17440                 17445             


Val Asp   Ala Ile Cys Thr His   Arg Leu Asp Pro Lys   Ser Pro Gly 
    17450                 17455                 17460             


Leu Xaa   Xaa Glu Xaa Leu Tyr   Trp Glu Leu Ser Xaa   Leu Thr Xaa 
    17465                 17470                 17475             


Xaa Ile   Xaa Glu Leu Gly Pro   Tyr Thr Leu Asp Arg   Xaa Ser Leu 
    17480                 17485                 17490             


Tyr Val   Asn Gly Phe Thr His   Xaa Xaa Ser Xaa Pro   Thr Thr Ser 
    17495                 17500                 17505             


Thr Pro   Gly Thr Ser Thr Val   Xaa Xaa Gly Thr Ser   Gly Thr Pro 
    17510                 17515                 17520             


Ser Ser   Xaa Pro Xaa Xaa Thr   Xaa Xaa Xaa Pro Leu   Leu Xaa Pro 
    17525                 17530                 17535             


Phe Thr   Xaa Asn Xaa Thr Ile   Thr Asn Leu Xaa Xaa   Xaa Xaa Xaa 
    17540                 17545                 17550             


Met Xaa   Xaa Pro Gly Ser Arg   Lys Phe Asn Thr Thr   Glu Xaa Val 
    17555                 17560                 17565             


Leu Gln   Gly Leu Leu Xaa Pro   Xaa Phe Lys Asn Xaa   Ser Val Gly 
    17570                 17575                 17580             


Xaa Leu   Tyr Ser Gly Cys Arg   Leu Thr Xaa Leu Arg   Xaa Glu Lys 
    17585                 17590                 17595             


Xaa Gly   Ala Ala Thr Gly Xaa   Asp Ala Ile Cys Xaa   His Xaa Xaa 
    17600                 17605                 17610             


Xaa Pro   Lys Xaa Pro Gly Leu   Xaa Xaa Glu Xaa Leu   Tyr Trp Glu 
    17615                 17620                 17625             


Leu Ser   Xaa Leu Thr Asn Ser   Ile Thr Glu Leu Gly   Pro Tyr Thr 
    17630                 17635                 17640             


Leu Asp   Arg Asp Ser Leu Tyr   Val Asn Gly Phe Thr   His Arg Ser 
    17645                 17650                 17655             


Ser Met   Pro Thr Thr Ser Ile   Pro Gly Thr Ser Ala   Val His Leu 
    17660                 17665                 17670             


Glu Thr   Ser Gly Thr Pro Ala   Ser Leu Pro Gly His   Thr Ala Pro 
    17675                 17680                 17685             


Gly Pro   Leu Leu Val Pro Phe   Thr Leu Asn Phe Thr   Ile Thr Asn 
    17690                 17695                 17700             


Leu Gln   Tyr Glu Glu Asp Met   Arg His Pro Gly Ser   Arg Lys Phe 
    17705                 17710                 17715             


Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu Leu Lys   Pro Leu Phe 
    17720                 17725                 17730             


Lys Ser   Thr Ser Val Gly Pro   Leu Tyr Ser Gly Cys   Arg Leu Thr 
    17735                 17740                 17745             


Leu Leu   Arg Pro Glu Lys Arg   Gly Ala Ala Thr Gly   Val Asp Thr 
    17750                 17755                 17760             


Ile Cys   Thr His Arg Leu Asp   Pro Leu Asn Pro Gly   Leu Xaa Xaa 
    17765                 17770                 17775             


Glu Xaa   Leu Tyr Trp Glu Leu   Ser Xaa Leu Thr Xaa   Xaa Ile Xaa 
    17780                 17785                 17790             


Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Xaa Ser Leu   Tyr Val Asn 
    17795                 17800                 17805             


Gly Phe   Thr His Xaa Xaa Ser   Xaa Pro Thr Thr Ser   Thr Pro Gly 
    17810                 17815                 17820             


Thr Ser   Thr Val Xaa Xaa Gly   Thr Ser Gly Thr Pro   Ser Ser Xaa 
    17825                 17830                 17835             


Pro Xaa   Xaa Thr Xaa Xaa Xaa   Pro Leu Leu Xaa Pro   Phe Thr Xaa 
    17840                 17845                 17850             


Asn Xaa   Thr Ile Thr Asn Leu   Xaa Xaa Xaa Xaa Xaa   Met Xaa Xaa 
    17855                 17860                 17865             


Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu Xaa Val   Leu Gln Gly 
    17870                 17875                 17880             


Leu Leu   Xaa Pro Xaa Phe Lys   Asn Xaa Ser Val Gly   Xaa Leu Tyr 
    17885                 17890                 17895             


Ser Gly   Cys Arg Leu Thr Xaa   Leu Arg Xaa Glu Lys   Xaa Gly Ala 
    17900                 17905                 17910             


Ala Thr   Gly Xaa Asp Ala Ile   Cys Xaa His Xaa Xaa   Xaa Pro Lys 
    17915                 17920                 17925             


Xaa Pro   Gly Leu Xaa Xaa Glu   Xaa Leu Tyr Trp Glu   Leu Ser Xaa 
    17930                 17935                 17940             


Leu Thr   Xaa Xaa Ile Xaa Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    17945                 17950                 17955             


Xaa Ser   Leu Tyr Val Asn Gly   Phe His Pro Arg Ser   Ser Val Pro 
    17960                 17965                 17970             


Thr Thr   Ser Thr Pro Gly Thr   Ser Thr Val His Leu   Ala Thr Ser 
    17975                 17980                 17985             


Gly Thr   Pro Ser Ser Leu Pro   Gly His Thr Ala Pro   Val Pro Leu 
    17990                 17995                 18000             


Leu Ile   Pro Phe Thr Leu Asn   Phe Thr Ile Thr Asn   Leu His Tyr 
    18005                 18010                 18015             


Glu Glu   Asn Met Gln His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    18020                 18025                 18030             


Glu Arg   Val Leu Gln Gly Leu   Leu Gly Pro Met Phe   Lys Asn Thr 
    18035                 18040                 18045             


Ser Val   Gly Leu Leu Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg 
    18050                 18055                 18060             


Pro Glu   Lys Asn Gly Ala Ala   Thr Gly Met Asp Ala   Ile Cys Ser 
    18065                 18070                 18075             


His Arg   Leu Asp Pro Lys Ser   Pro Gly Leu Xaa Xaa   Glu Xaa Leu 
    18080                 18085                 18090             


Tyr Trp   Glu Leu Ser Xaa Leu   Thr Xaa Xaa Ile Xaa   Glu Leu Gly 
    18095                 18100                 18105             


Pro Tyr   Thr Leu Asp Arg Xaa   Ser Leu Tyr Val Asn   Gly Phe Thr 
    18110                 18115                 18120             


His Xaa   Xaa Ser Xaa Pro Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    18125                 18130                 18135             


Val Xaa   Xaa Gly Thr Ser Gly   Thr Pro Ser Ser Xaa   Pro Xaa Xaa 
    18140                 18145                 18150             


Thr Xaa   Xaa Xaa Pro Leu Leu   Xaa Pro Phe Thr Xaa   Asn Xaa Thr 
    18155                 18160                 18165             


Ile Thr   Asn Leu Xaa Xaa Xaa   Xaa Xaa Met Xaa Xaa   Pro Gly Ser 
    18170                 18175                 18180             


Arg Lys   Phe Asn Thr Thr Glu   Xaa Val Leu Gln Gly   Leu Leu Xaa 
    18185                 18190                 18195             


Pro Xaa   Phe Lys Asn Xaa Ser   Val Gly Xaa Leu Tyr   Ser Gly Cys 
    18200                 18205                 18210             


Arg Leu   Thr Xaa Leu Arg Xaa   Glu Lys Xaa Gly Ala   Ala Thr Gly 
    18215                 18220                 18225             


Xaa Asp   Ala Ile Cys Xaa His   Xaa Xaa Xaa Pro Lys   Xaa Pro Gly 
    18230                 18235                 18240             


Leu Xaa   Xaa Glu Xaa Leu Tyr   Trp Glu Leu Ser Xaa   Leu Thr Xaa 
    18245                 18250                 18255             


Xaa Ile   Xaa Glu Leu Gly Pro   Tyr Thr Leu Asp Arg   Xaa Ser Leu 
    18260                 18265                 18270             


Tyr Val   Asn Gly Phe Thr His   Gln Asn Ser Val Pro   Thr Thr Ser 
    18275                 18280                 18285             


Thr Pro   Gly Thr Ser Thr Val   Tyr Trp Ala Thr Thr   Gly Thr Pro 
    18290                 18295                 18300             


Ser Ser   Phe Pro Gly His Thr   Glu Pro Gly Pro Leu   Leu Ile Pro 
    18305                 18310                 18315             


Phe Thr   Phe Asn Phe Thr Ile   Thr Asn Leu His Tyr   Glu Glu Asn 
    18320                 18325                 18330             


Met Gln   His Pro Gly Ser Arg   Lys Phe Asn Thr Thr   Glu Arg Val 
    18335                 18340                 18345             


Leu Gln   Gly Leu Leu Thr Pro   Leu Phe Lys Asn Thr   Ser Val Gly 
    18350                 18355                 18360             


Pro Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu Leu Arg   Pro Glu Lys 
    18365                 18370                 18375             


Gln Glu   Ala Ala Thr Gly Val   Asp Thr Ile Cys Thr   His Arg Val 
    18380                 18385                 18390             


Asp Pro   Ile Gly Pro Gly Leu   Xaa Xaa Glu Xaa Leu   Tyr Trp Glu 
    18395                 18400                 18405             


Leu Ser   Xaa Leu Thr Xaa Xaa   Ile Xaa Glu Leu Gly   Pro Tyr Thr 
    18410                 18415                 18420             


Leu Asp   Arg Xaa Ser Leu Tyr   Val Asn Gly Phe Thr   His Xaa Xaa 
    18425                 18430                 18435             


Ser Xaa   Pro Thr Thr Ser Thr   Pro Gly Thr Ser Thr   Val Xaa Xaa 
    18440                 18445                 18450             


Gly Thr   Ser Gly Thr Pro Ser   Ser Xaa Pro Xaa Xaa   Thr Xaa Xaa 
    18455                 18460                 18465             


Xaa Pro   Leu Leu Xaa Pro Phe   Thr Xaa Asn Xaa Thr   Ile Thr Asn 
    18470                 18475                 18480             


Leu Xaa   Xaa Xaa Xaa Xaa Met   Xaa Xaa Pro Gly Ser   Arg Lys Phe 
    18485                 18490                 18495             


Asn Thr   Thr Glu Xaa Val Leu   Gln Gly Leu Leu Xaa   Pro Xaa Phe 
    18500                 18505                 18510             


Lys Asn   Xaa Ser Val Gly Xaa   Leu Tyr Ser Gly Cys   Arg Leu Thr 
    18515                 18520                 18525             


Xaa Leu   Arg Xaa Glu Lys Xaa   Gly Ala Ala Thr Gly   Xaa Asp Ala 
    18530                 18535                 18540             


Ile Cys   Xaa His Xaa Xaa Xaa   Pro Lys Xaa Pro Gly   Leu Xaa Xaa 
    18545                 18550                 18555             


Glu Xaa   Leu Tyr Trp Glu Leu   Ser Xaa Leu Thr Xaa   Xaa Ile Xaa 
    18560                 18565                 18570             


Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Xaa Ser Leu   Tyr Val Asn 
    18575                 18580                 18585             


Gly Phe   Thr His Arg Ser Ser   Val Pro Thr Thr Ser   Ser Pro Gly 
    18590                 18595                 18600             


Thr Ser   Thr Val His Leu Ala   Thr Ser Gly Thr Pro   Ser Ser Leu 
    18605                 18610                 18615             


Pro Gly   His Thr Ala Pro Val   Pro Leu Leu Ile Pro   Phe Thr Leu 
    18620                 18625                 18630             


Asn Phe   Thr Ile Thr Asn Leu   His Tyr Glu Glu Asn   Met Gln His 
    18635                 18640                 18645             


Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu Arg Val   Leu Gln Gly 
    18650                 18655                 18660             


Leu Leu   Lys Pro Leu Phe Lys   Ser Thr Ser Val Gly   Pro Leu Tyr 
    18665                 18670                 18675             


Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Pro Glu Lys   His Gly Ala 
    18680                 18685                 18690             


Ala Thr   Gly Val Asp Ala Ile   Cys Thr Leu Arg Leu   Asp Pro Thr 
    18695                 18700                 18705             


Gly Pro   Gly Leu Xaa Xaa Glu   Xaa Leu Tyr Trp Glu   Leu Ser Xaa 
    18710                 18715                 18720             


Leu Thr   Xaa Xaa Ile Xaa Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    18725                 18730                 18735             


Xaa Ser   Leu Tyr Val Asn Gly   Phe Thr His Xaa Xaa   Ser Xaa Pro 
    18740                 18745                 18750             


Thr Thr   Ser Thr Pro Gly Thr   Ser Thr Val Xaa Xaa   Gly Thr Ser 
    18755                 18760                 18765             


Gly Thr   Pro Ser Ser Xaa Pro   Xaa Xaa Thr Xaa Xaa   Xaa Pro Leu 
    18770                 18775                 18780             


Leu Xaa   Pro Phe Thr Xaa Asn   Xaa Thr Ile Thr Asn   Leu Xaa Xaa 
    18785                 18790                 18795             


Xaa Xaa   Xaa Met Xaa Xaa Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    18800                 18805                 18810             


Glu Xaa   Val Leu Gln Gly Leu   Leu Xaa Pro Xaa Phe   Lys Asn Xaa 
    18815                 18820                 18825             


Ser Val   Gly Xaa Leu Tyr Ser   Gly Cys Arg Leu Thr   Xaa Leu Arg 
    18830                 18835                 18840             


Xaa Glu   Lys Xaa Gly Ala Ala   Thr Gly Xaa Asp Ala   Ile Cys Xaa 
    18845                 18850                 18855             


His Xaa   Xaa Xaa Pro Lys Xaa   Pro Gly Leu Xaa Xaa   Glu Xaa Leu 
    18860                 18865                 18870             


Tyr Trp   Glu Leu Ser Xaa Leu   Thr Xaa Xaa Ile Xaa   Glu Leu Gly 
    18875                 18880                 18885             


Pro Tyr   Thr Leu Asp Arg Xaa   Ser Leu Tyr Val Asn   Gly Phe Thr 
    18890                 18895                 18900             


His Arg   Thr Ser Val Pro Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    18905                 18910                 18915             


Val His   Leu Ala Thr Ser Gly   Thr Pro Ser Ser Leu   Pro Gly His 
    18920                 18925                 18930             


Thr Ala   Pro Val Pro Leu Leu   Ile Pro Phe Thr Leu   Asn Phe Thr 
    18935                 18940                 18945             


Ile Thr   Asn Leu Gln Tyr Glu   Glu Asp Met His Arg   Pro Gly Ser 
    18950                 18955                 18960             


Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu Gln Gly   Leu Leu Ser 
    18965                 18970                 18975             


Pro Ile   Phe Lys Asn Ser Ser   Val Gly Pro Leu Tyr   Ser Gly Cys 
    18980                 18985                 18990             


Arg Leu   Thr Ser Leu Arg Pro   Glu Lys Asp Gly Ala   Ala Thr Gly 
    18995                 19000                 19005             


Met Asp   Ala Val Cys Leu Tyr   His Pro Asn Pro Lys   Arg Pro Gly 
    19010                 19015                 19020             


Leu Asp   Arg Glu Gln Leu Tyr   Cys Glu Leu Ser Gln   Leu Thr His 
    19025                 19030                 19035             


Asn Ile   Thr Glu Leu Gly Pro   Tyr Ser Leu Asp Arg   Asp Ser Leu 
    19040                 19045                 19050             


Tyr Val   Asn Gly Phe Thr His   Gln Asn Ser Val Pro   Thr Thr Ser 
    19055                 19060                 19065             


Thr Pro   Gly Thr Ser Thr Val   Tyr Trp Ala Thr Thr   Gly Thr Pro 
    19070                 19075                 19080             


Ser Ser   Phe Pro Gly His Thr   Xaa Xaa Xaa Pro Leu   Leu Xaa Pro 
    19085                 19090                 19095             


Phe Thr   Xaa Asn Xaa Thr Ile   Thr Asn Leu Xaa Xaa   Xaa Xaa Xaa 
    19100                 19105                 19110             


Met Xaa   Xaa Pro Gly Ser Arg   Lys Phe Asn Thr Thr   Glu Xaa Val 
    19115                 19120                 19125             


Leu Gln   Gly Leu Leu Xaa Pro   Xaa Phe Lys Asn Xaa   Ser Val Gly 
    19130                 19135                 19140             


Xaa Leu   Tyr Ser Gly Cys Arg   Leu Thr Xaa Leu Arg   Xaa Glu Lys 
    19145                 19150                 19155             


Xaa Gly   Ala Ala Thr Gly Xaa   Asp Ala Ile Cys Xaa   His Xaa Xaa 
    19160                 19165                 19170             


Xaa Pro   Lys Xaa Pro Gly Leu   Xaa Xaa Glu Xaa Leu   Tyr Trp Glu 
    19175                 19180                 19185             


Leu Ser   Xaa Leu Thr Xaa Xaa   Ile Xaa Glu Leu Gly   Pro Tyr Thr 
    19190                 19195                 19200             


Leu Asp   Arg Xaa Ser Leu Tyr   Val Asn Gly Phe Thr   His Trp Ser 
    19205                 19210                 19215             


Ser Gly   Leu Thr Thr Ser Thr   Pro Trp Thr Ser Thr   Val Asp Leu 
    19220                 19225                 19230             


Gly Thr   Ser Gly Thr Pro Ser   Pro Val Pro Ser Pro   Thr Thr Ala 
    19235                 19240                 19245             


Gly Pro   Leu Leu Val Pro Phe   Thr Leu Asn Phe Thr   Ile Thr Asn 
    19250                 19255                 19260             


Leu Gln   Tyr Glu Glu Asp Met   His Arg Pro Gly Ser   Arg Lys Phe 
    19265                 19270                 19275             


Asn Ala   Thr Glu Arg Val Leu   Gln Gly Leu Leu Ser   Pro Ile Phe 
    19280                 19285                 19290             


Lys Asn   Thr Ser Val Gly Pro   Leu Tyr Ser Gly Cys   Arg Leu Thr 
    19295                 19300                 19305             


Leu Leu   Arg Pro Glu Lys Gln   Glu Ala Ala Thr Gly   Val Asp Thr 
    19310                 19315                 19320             


Ile Cys   Thr His Arg Val Asp   Pro Ile Gly Pro Gly   Leu Xaa Xaa 
    19325                 19330                 19335             


Glu Xaa   Leu Tyr Trp Glu Leu   Ser Xaa Leu Thr Xaa   Xaa Ile Xaa 
    19340                 19345                 19350             


Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Xaa Ser Leu   Tyr Val Asn 
    19355                 19360                 19365             


Gly Phe   Thr His Xaa Xaa Ser   Xaa Pro Thr Thr Ser   Thr Pro Gly 
    19370                 19375                 19380             


Thr Ser   Thr Val Xaa Xaa Gly   Thr Ser Gly Thr Pro   Ser Ser Xaa 
    19385                 19390                 19395             


Pro Xaa   Xaa Thr Xaa Xaa Xaa   Pro Leu Leu Xaa Pro   Phe Thr Xaa 
    19400                 19405                 19410             


Asn Xaa   Thr Ile Thr Asn Leu   Xaa Xaa Xaa Xaa Xaa   Met Xaa Xaa 
    19415                 19420                 19425             


Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu Xaa Val   Leu Gln Gly 
    19430                 19435                 19440             


Leu Leu   Xaa Pro Xaa Phe Lys   Asn Xaa Ser Val Gly   Xaa Leu Tyr 
    19445                 19450                 19455             


Ser Gly   Cys Arg Leu Thr Xaa   Leu Arg Xaa Glu Lys   Xaa Gly Ala 
    19460                 19465                 19470             


Ala Thr   Gly Xaa Asp Ala Ile   Cys Xaa His Xaa Xaa   Xaa Pro Lys 
    19475                 19480                 19485             


Xaa Pro   Gly Leu Xaa Xaa Glu   Xaa Leu Tyr Trp Glu   Leu Ser Xaa 
    19490                 19495                 19500             


Leu Thr   Xaa Xaa Ile Xaa Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    19505                 19510                 19515             


Xaa Ser   Leu Tyr Val Asn Gly   Phe Thr His Arg Ser   Phe Gly Leu 
    19520                 19525                 19530             


Thr Thr   Ser Thr Pro Trp Thr   Ser Thr Val Asp Leu   Gly Thr Ser 
    19535                 19540                 19545             


Gly Thr   Pro Ser Pro Val Pro   Ser Pro Thr Thr Ala   Gly Pro Leu 
    19550                 19555                 19560             


Leu Val   Pro Phe Thr Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr 
    19565                 19570                 19575             


Glu Glu   Asp Met His Arg Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    19580                 19585                 19590             


Glu Arg   Val Leu Gln Gly Leu   Leu Thr Pro Leu Phe   Arg Asn Thr 
    19595                 19600                 19605             


Ser Val   Ser Ser Leu Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg 
    19610                 19615                 19620             


Pro Glu   Lys Asp Gly Ala Ala   Thr Arg Val Asp Ala   Val Cys Thr 
    19625                 19630                 19635             


His Arg   Pro Asp Pro Lys Ser   Pro Gly Leu Xaa Xaa   Glu Xaa Leu 
    19640                 19645                 19650             


Tyr Trp   Glu Leu Ser Xaa Leu   Thr Xaa Xaa Ile Xaa   Glu Leu Gly 
    19655                 19660                 19665             


Pro Tyr   Thr Leu Asp Arg Xaa   Ser Leu Tyr Val Asn   Gly Phe Thr 
    19670                 19675                 19680             


His Xaa   Xaa Ser Xaa Pro Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    19685                 19690                 19695             


Val Xaa   Xaa Gly Thr Ser Gly   Thr Pro Ser Ser Xaa   Pro Xaa Xaa 
    19700                 19705                 19710             


Thr Xaa   Xaa Xaa Pro Leu Leu   Xaa Pro Phe Thr Xaa   Asn Xaa Thr 
    19715                 19720                 19725             


Ile Thr   Asn Leu Xaa Xaa Xaa   Xaa Xaa Met Xaa Xaa   Pro Gly Ser 
    19730                 19735                 19740             


Arg Lys   Phe Asn Thr Thr Glu   Xaa Val Leu Gln Gly   Leu Leu Xaa 
    19745                 19750                 19755             


Pro Xaa   Phe Lys Asn Xaa Ser   Val Gly Xaa Leu Tyr   Ser Gly Cys 
    19760                 19765                 19770             


Arg Leu   Thr Xaa Leu Arg Xaa   Glu Lys Xaa Gly Ala   Ala Thr Gly 
    19775                 19780                 19785             


Xaa Asp   Ala Ile Cys Xaa His   Xaa Xaa Xaa Pro Lys   Xaa Pro Gly 
    19790                 19795                 19800             


Leu Xaa   Xaa Glu Xaa Leu Tyr   Trp Glu Leu Ser Xaa   Leu Thr Xaa 
    19805                 19810                 19815             


Xaa Ile   Xaa Glu Leu Gly Pro   Tyr Thr Leu Asp Arg   Xaa Ser Leu 
    19820                 19825                 19830             


Tyr Val   Asn Gly Phe Thr His   Trp Ile Pro Val Pro   Thr Ser Ser 
    19835                 19840                 19845             


Thr Pro   Gly Thr Ser Thr Val   Asp Leu Gly Ser Gly   Thr Pro Ser 
    19850                 19855                 19860             


Ser Leu   Pro Ser Pro Thr Thr   Ala Gly Pro Leu Leu   Val Pro Phe 
    19865                 19870                 19875             


Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Gln Tyr Gly   Glu Asp Met 
    19880                 19885                 19890             


Gly His   Pro Gly Ser Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu 
    19895                 19900                 19905             


Gln Gly   Leu Leu Gly Pro Ile   Phe Lys Asn Thr Ser   Val Gly Pro 
    19910                 19915                 19920             


Leu Tyr   Ser Gly Cys Arg Leu   Thr Ser Leu Arg Ser   Glu Lys Asp 
    19925                 19930                 19935             


Gly Ala   Ala Thr Gly Val Asp   Ala Ile Cys Ile His   His Leu Asp 
    19940                 19945                 19950             


Pro Lys   Ser Pro Gly Leu Xaa   Xaa Glu Xaa Leu Tyr   Trp Glu Leu 
    19955                 19960                 19965             


Ser Xaa   Leu Thr Xaa Xaa Ile   Xaa Glu Leu Gly Pro   Tyr Thr Leu 
    19970                 19975                 19980             


Asp Arg   Xaa Ser Leu Tyr Val   Asn Gly Phe Thr His   Xaa Xaa Ser 
    19985                 19990                 19995             


Xaa Pro   Thr Thr Ser Thr Pro   Gly Thr Ser Thr Val   Xaa Xaa Gly 
    20000                 20005                 20010             


Thr Ser   Gly Thr Pro Ser Ser   Xaa Pro Xaa Xaa Thr   Xaa Xaa Xaa 
    20015                 20020                 20025             


Pro Leu   Leu Xaa Pro Phe Thr   Xaa Asn Xaa Thr Ile   Thr Asn Leu 
    20030                 20035                 20040             


Xaa Xaa   Xaa Xaa Xaa Met Xaa   Xaa Pro Gly Ser Arg   Lys Phe Asn 
    20045                 20050                 20055             


Thr Thr   Glu Xaa Val Leu Gln   Gly Leu Leu Xaa Pro   Xaa Phe Lys 
    20060                 20065                 20070             


Asn Xaa   Ser Val Gly Xaa Leu   Tyr Ser Gly Cys Arg   Leu Thr Xaa 
    20075                 20080                 20085             


Leu Arg   Xaa Glu Lys Xaa Gly   Ala Ala Thr Gly Xaa   Asp Ala Ile 
    20090                 20095                 20100             


Cys Xaa   His Xaa Xaa Xaa Pro   Lys Xaa Pro Gly Leu   Xaa Xaa Glu 
    20105                 20110                 20115             


Xaa Leu   Tyr Trp Glu Leu Ser   Xaa Leu Thr Xaa Xaa   Ile Xaa Glu 
    20120                 20125                 20130             


Leu Gly   Pro Tyr Thr Leu Asp   Arg Xaa Ser Leu Tyr   Val Asn Gly 
    20135                 20140                 20145             


Phe Thr   His Gln Thr Phe Ala   Pro Asn Thr Ser Thr   Pro Gly Thr 
    20150                 20155                 20160             


Ser Thr   Val Asp Leu Gly Thr   Ser Gly Thr Pro Ser   Ser Leu Pro 
    20165                 20170                 20175             


Ser Pro   Thr Ser Ala Gly Pro   Leu Leu Val Pro Phe   Thr Leu Asn 
    20180                 20185                 20190             


Phe Thr   Ile Thr Asn Leu Gln   Tyr Glu Glu Asp Met   His His Pro 
    20195                 20200                 20205             


Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu 
    20210                 20215                 20220             


Leu Gly   Pro Met Phe Lys Asn   Thr Ser Val Gly Leu   Leu Tyr Ser 
    20225                 20230                 20235             


Gly Cys   Arg Leu Thr Leu Leu   Arg Pro Glu Lys Asn   Gly Ala Ala 
    20240                 20245                 20250             


Thr Arg   Val Asp Ala Val Cys   Thr His Arg Pro Asp   Pro Lys Ser 
    20255                 20260                 20265             


Pro Gly   Leu Xaa Xaa Glu Xaa   Leu Tyr Trp Glu Leu   Ser Xaa Leu 
    20270                 20275                 20280             


Thr Xaa   Xaa Ile Xaa Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Xaa 
    20285                 20290                 20295             


Ser Leu   Tyr Val Asn Gly Phe   Thr His Xaa Xaa Ser   Xaa Pro Thr 
    20300                 20305                 20310             


Thr Ser   Thr Pro Gly Thr Ser   Thr Val Xaa Xaa Gly   Thr Ser Gly 
    20315                 20320                 20325             


Thr Pro   Ser Ser Xaa Pro Xaa   Xaa Thr Ala Pro Val   Pro Leu Leu 
    20330                 20335                 20340             


Ile Pro   Phe Thr Leu Asn Phe   Thr Ile Thr Asn Leu   His Tyr Glu 
    20345                 20350                 20355             


Glu Asn   Met Gln His Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu 
    20360                 20365                 20370             


Arg Val   Leu Gln Gly Leu Leu   Lys Pro Leu Phe Lys   Ser Thr Ser 
    20375                 20380                 20385             


Val Gly   Pro Leu Tyr Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Pro 
    20390                 20395                 20400             


Glu Lys   His Gly Ala Ala Thr   Gly Val Asp Ala Ile   Cys Thr Leu 
    20405                 20410                 20415             


Arg Leu   Asp Pro Thr Gly Pro   Gly Leu Asp Arg Glu   Arg Leu Tyr 
    20420                 20425                 20430             


Trp Glu   Leu Ser Gln Leu Thr   Asn Ser Val Thr Glu   Leu Gly Pro 
    20435                 20440                 20445             


Tyr Thr   Leu Asp Arg Asp Ser   Leu Tyr Val Asn Gly   Phe Thr Gln 
    20450                 20455                 20460             


Arg Ser   Ser Val Pro Thr Thr   Ser Ile Pro Gly Thr   Ser Ala Val 
    20465                 20470                 20475             


His Leu   Glu Thr Ser Gly Thr   Pro Ala Ser Leu Pro   Gly His Thr 
    20480                 20485                 20490             


Ala Pro   Gly Pro Leu Leu Val   Pro Phe Thr Leu Asn   Phe Thr Ile 
    20495                 20500                 20505             


Thr Asn   Leu Gln Tyr Glu Val   Asp Met Arg His Pro   Gly Ser Arg 
    20510                 20515                 20520             


Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln Gly Leu   Leu Lys Pro 
    20525                 20530                 20535             


Leu Phe   Lys Ser Thr Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg 
    20540                 20545                 20550             


Leu Thr   Leu Leu Arg Pro Glu   Lys Arg Gly Ala Ala   Thr Gly Val 
    20555                 20560                 20565             


Asp Thr   Ile Cys Thr His Arg   Leu Asp Pro Leu Asn   Pro Gly Leu 
    20570                 20575                 20580             


Asp Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser Lys Leu   Thr Arg Gly 
    20585                 20590                 20595             


Ile Ile   Glu Leu Gly Pro Tyr   Leu Leu Asp Arg Gly   Ser Leu Tyr 
    20600                 20605                 20610             


Val Asn   Gly Phe Thr His Arg   Asn Phe Val Pro Ile   Thr Ser Thr 
    20615                 20620                 20625             


Pro Gly   Thr Ser Thr Val His   Leu Gly Thr Ser Glu   Thr Pro Ser 
    20630                 20635                 20640             


Ser Leu   Pro Arg Pro Ile Val   Pro Gly Pro Leu Leu   Val Pro Phe 
    20645                 20650                 20655             


Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Gln Tyr Glu   Glu Ala Met 
    20660                 20665                 20670             


Arg His   Pro Gly Ser Arg Lys   Phe Asn Thr Thr Glu   Arg Val Leu 
    20675                 20680                 20685             


Gln Gly   Leu Leu Arg Pro Leu   Phe Lys Asn Thr Ser   Ile Gly Pro 
    20690                 20695                 20700             


Leu Tyr   Ser Ser Cys Arg Leu   Thr Leu Leu Arg Pro   Glu Lys Asp 
    20705                 20710                 20715             


Lys Ala   Ala Thr Arg Val Asp   Ala Ile Cys Thr His   His Pro Asp 
    20720                 20725                 20730             


Pro Gln   Ser Pro Gly Leu Asn   Arg Glu Gln Leu Tyr   Trp Glu Leu 
    20735                 20740                 20745             


Ser Gln   Leu Thr His Gly Ile   Thr Glu Leu Gly Pro   Tyr Thr Leu 
    20750                 20755                 20760             


Asp Arg   Asp Ser Leu Tyr Val   Asp Gly Phe Thr His   Trp Ser Pro 
    20765                 20770                 20775             


Ile Pro   Thr Thr Ser Thr Pro   Gly Thr Ser Ile Val   Asn Leu Gly 
    20780                 20785                 20790             


Thr Ser   Gly Ile Pro Pro Ser   Leu Pro Glu Thr Thr   Xaa Xaa Xaa 
    20795                 20800                 20805             


Pro Leu   Leu Xaa Pro Phe Thr   Xaa Asn Xaa Thr Ile   Thr Asn Leu 
    20810                 20815                 20820             


Xaa Xaa   Xaa Xaa Xaa Met Xaa   Xaa Pro Gly Ser Arg   Lys Phe Asn 
    20825                 20830                 20835             


Thr Thr   Glu Arg Val Leu Gln   Gly Leu Leu Lys Pro   Leu Phe Lys 
    20840                 20845                 20850             


Ser Thr   Ser Val Gly Pro Leu   Tyr Ser Gly Cys Arg   Leu Thr Leu 
    20855                 20860                 20865             


Leu Arg   Pro Glu Lys Asp Gly   Val Ala Thr Arg Val   Asp Ala Ile 
    20870                 20875                 20880             


Cys Thr   His Arg Pro Asp Pro   Lys Ile Pro Gly Leu   Asp Arg Gln 
    20885                 20890                 20895             


Gln Leu   Tyr Trp Glu Leu Ser   Gln Leu Thr His Ser   Ile Thr Glu 
    20900                 20905                 20910             


Leu Gly   Pro Tyr Thr Leu Asp   Arg Asp Ser Leu Tyr   Val Asn Gly 
    20915                 20920                 20925             


Phe Thr   Gln Arg Ser Ser Val   Pro Thr Thr Ser Thr   Pro Gly Thr 
    20930                 20935                 20940             


Phe Thr   Val Gln Pro Glu Thr   Ser Glu Thr Pro Ser   Ser Leu Pro 
    20945                 20950                 20955             


Gly Pro   Thr Ala Thr Gly Pro   Val Leu Leu Pro Phe   Thr Leu Asn 
    20960                 20965                 20970             


Phe Thr   Ile Thr Asn Leu Gln   Tyr Glu Glu Asp Met   His Arg Pro 
    20975                 20980                 20985             


Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu 
    20990                 20995                 21000             


Leu Met   Pro Leu Phe Lys Asn   Thr Ser Val Ser Ser   Leu Tyr Ser 
    21005                 21010                 21015             


Gly Cys   Arg Leu Thr Leu Leu   Arg Pro Glu Lys Asp   Gly Ala Ala 
    21020                 21025                 21030             


Thr Arg   Val Asp Ala Val Cys   Thr His Arg Pro Asp   Pro Lys Ser 
    21035                 21040                 21045             


Pro Gly   Leu Asp Arg Glu Arg   Leu Tyr Trp Lys Leu   Ser Gln Leu 
    21050                 21055                 21060             


Thr His   Gly Ile Thr Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg His 
    21065                 21070                 21075             


Ser Leu   Tyr Val Asn Gly Phe   Thr His Gln Ser Ser   Met Thr Thr 
    21080                 21085                 21090             


Thr Arg   Thr Pro Asp Thr Ser   Thr Met His Leu Ala   Thr Ser Arg 
    21095                 21100                 21105             


Thr Pro   Ala Ser Leu Ser Gly   Pro Thr Thr Ala Ser   Pro Leu Leu 
    21110                 21115                 21120             


Val Leu   Phe Thr Ile Asn Phe   Thr Ile Thr Asn Leu   Arg Tyr Glu 
    21125                 21130                 21135             


Glu Asn   Met His His Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu 
    21140                 21145                 21150             


Arg Val   Leu Gln Gly Leu Leu   Arg Pro Val Phe Lys   Asn Thr Ser 
    21155                 21160                 21165             


Val Gly   Pro Leu Tyr Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Pro 
    21170                 21175                 21180             


Lys Lys   Asp Gly Ala Ala Thr   Lys Val Asp Ala Ile   Cys Thr Tyr 
    21185                 21190                 21195             


Arg Pro   Asp Pro Lys Ser Pro   Gly Leu Asp Arg Glu   Gln Leu Tyr 
    21200                 21205                 21210             


Trp Glu   Leu Ser Gln Leu Thr   His Ser Ile Thr Glu   Leu Gly Pro 
    21215                 21220                 21225             


Tyr Thr   Leu Asp Arg Asp Ser   Leu Tyr Val Asn Gly   Phe Thr Gln 
    21230                 21235                 21240             


Arg Ser   Ser Val Pro Thr Thr   Ser Ile Pro Gly Thr   Pro Thr Val 
    21245                 21250                 21255             


Asp Leu   Gly Thr Ser Gly Thr   Pro Val Ser Lys Pro   Gly Pro Ser 
    21260                 21265                 21270             


Ala Ala   Ser Pro Leu Leu Val   Leu Phe Thr Leu Asn   Phe Thr Ile 
    21275                 21280                 21285             


Thr Asn   Leu Arg Tyr Glu Glu   Asn Met Gln His Pro   Gly Ser Arg 
    21290                 21295                 21300             


Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln Gly Leu   Leu Arg Ser 
    21305                 21310                 21315             


Leu Phe   Lys Ser Thr Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg 
    21320                 21325                 21330             


Leu Thr   Leu Leu Arg Pro Glu   Lys Asp Gly Thr Ala   Thr Gly Val 
    21335                 21340                 21345             


Asp Ala   Ile Cys Thr His His   Pro Asp Pro Lys Ser   Pro Arg Leu 
    21350                 21355                 21360             


Asp Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser Gln Leu   Thr His Asn 
    21365                 21370                 21375             


Ile Thr   Glu Leu Gly His Tyr   Ala Leu Asp Asn Asp   Ser Leu Phe 
    21380                 21385                 21390             


Val Asn   Gly Phe Thr His Arg   Ser Ser Val Ser Thr   Thr Ser Thr 
    21395                 21400                 21405             


Pro Gly   Thr Pro Thr Val Tyr   Leu Gly Ala Ser Lys   Thr Pro Ala 
    21410                 21415                 21420             


Ser Ile   Phe Gly Pro Ser Ala   Ala Ser His Leu Leu   Ile Leu Phe 
    21425                 21430                 21435             


Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Arg Tyr Glu   Glu Asn Met 
    21440                 21445                 21450             


Trp Pro   Gly Ser Arg Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln 
    21455                 21460                 21465             


Gly Leu   Leu Arg Pro Leu Phe   Lys Asn Thr Ser Val   Gly Pro Leu 
    21470                 21475                 21480             


Tyr Ser   Gly Ser Arg Leu Thr   Leu Leu Arg Pro Glu   Lys Asp Gly 
    21485                 21490                 21495             


Glu Ala   Thr Gly Val Asp Ala   Ile Cys Thr His Arg   Pro Asp Pro 
    21500                 21505                 21510             


Thr Gly   Pro Gly Leu Asp Arg   Glu Gln Leu Tyr Leu   Glu Leu Ser 
    21515                 21520                 21525             


Gln Leu   Thr His Ser Ile Thr   Glu Leu Gly Pro Tyr   Thr Leu Asp 
    21530                 21535                 21540             


Arg Asp   Ser Leu Tyr Val Asn   Gly Phe Thr His Arg   Ser Ser Val 
    21545                 21550                 21555             


Pro Thr   Thr Ser Thr Gly Val   Val Ser Glu Glu Pro   Phe Thr Leu 
    21560                 21565                 21570             


Asn Phe   Thr Ile Asn Asn Leu   Arg Tyr Met Ala Asp   Met Gly Gln 
    21575                 21580                 21585             


Pro Gly   Ser Leu Lys Phe Asn   Ile Thr Asp Asn Val   Met Lys His 
    21590                 21595                 21600             


Leu Leu   Ser Pro Leu Phe Gln   Arg Ser Ser Leu Gly   Ala Arg Tyr 
    21605                 21610                 21615             


Thr Gly   Cys Arg Val Ile Ala   Leu Arg Ser Val Lys   Asn Gly Ala 
    21620                 21625                 21630             


Glu Thr   Arg Val Asp Leu Leu   Cys Thr Tyr Leu Gln   Pro Leu Ser 
    21635                 21640                 21645             


Gly Pro   Gly Leu Pro Ile Lys   Gln Val Phe His Glu   Leu Ser Gln 
    21650                 21655                 21660             


Gln Thr   His Gly Ile Thr Arg   Leu Gly Pro Tyr Ser   Leu Asp Lys 
    21665                 21670                 21675             


Asp Ser   Leu Tyr Leu Asn Gly   Tyr Asn Glu Pro Gly   Leu Asp Glu 
    21680                 21685                 21690             


Pro Pro   Thr Thr Pro Lys Pro   Ala Thr Thr Phe Leu   Pro Pro Leu 
    21695                 21700                 21705             


Ser Glu   Ala Thr Thr Ala Met   Gly Tyr His Leu Lys   Thr Leu Thr 
    21710                 21715                 21720             


Leu Asn   Phe Thr Ile Ser Asn   Leu Gln Tyr Ser Pro   Asp Met Gly 
    21725                 21730                 21735             


Lys Gly   Ser Ala Thr Phe Asn   Ser Thr Glu Gly Val   Leu Gln His 
    21740                 21745                 21750             


Leu Leu   Arg Pro Leu Phe Gln   Lys Ser Ser Met Gly   Pro Phe Tyr 
    21755                 21760                 21765             


Leu Gly   Cys Gln Leu Ile Ser   Leu Arg Pro Glu Lys   Asp Gly Ala 
    21770                 21775                 21780             


Ala Thr   Gly Val Asp Thr Thr   Cys Thr Tyr His Pro   Asp Pro Val 
    21785                 21790                 21795             


Gly Pro   Gly Leu Asp Ile Gln   Gln Leu Tyr Trp Glu   Leu Ser Gln 
    21800                 21805                 21810             


Leu Thr   His Gly Val Thr Gln   Leu Gly Phe Tyr Val   Leu Asp Arg 
    21815                 21820                 21825             


Asp Ser   Leu Phe Ile Asn Gly   Tyr Ala Pro Gln Asn   Leu Ser Ile 
    21830                 21835                 21840             


Arg Gly   Glu Tyr Gln Ile Asn   Phe His Ile Val Asn   Trp Asn Leu 
    21845                 21850                 21855             


Ser Asn   Pro Asp Pro Thr Ser   Ser Glu Tyr Ile Thr   Leu Leu Arg 
    21860                 21865                 21870             


Asp Ile   Gln Asp Lys Val Thr   Thr Leu Tyr Lys Gly   Ser Gln Leu 
    21875                 21880                 21885             


His Asp   Thr Phe Arg Phe Cys   Leu Val Thr Asn Leu   Thr Met Asp 
    21890                 21895                 21900             


Ser Val   Leu Val Thr Val Lys   Ala Leu Phe Ser Ser   Asn Leu Asp 
    21905                 21910                 21915             


Pro Ser   Leu Val Glu Gln Val   Phe Leu Asp Lys Thr   Leu Asn Ala 
    21920                 21925                 21930             


Ser Phe   His Trp Leu Gly Ser   Thr Tyr Gln Leu Val   Asp Ile His 
    21935                 21940                 21945             


Val Thr   Glu Met Glu Ser Ser   Val Tyr Gln Pro Thr   Ser Ser Ser 
    21950                 21955                 21960             


Ser Thr   Gln His Phe Tyr Leu   Asn Phe Thr Ile Thr   Asn Leu Pro 
    21965                 21970                 21975             


Tyr Ser   Gln Asp Lys Ala Gln   Pro Gly Thr Thr Asn   Tyr Gln Arg 
    21980                 21985                 21990             


Asn Lys   Arg Asn Ile Glu Asp   Ala Leu Asn Gln Leu   Phe Arg Asn 
    21995                 22000                 22005             


Ser Ser   Ile Lys Ser Tyr Phe   Ser Asp Cys Gln Val   Ser Thr Phe 
    22010                 22015                 22020             


Arg Ser   Val Pro Asn Arg His   His Thr Gly Val Asp   Ser Leu Cys 
    22025                 22030                 22035             


Asn Phe   Ser Pro Leu Ala Arg   Arg Val Asp Arg Val   Ala Ile Tyr 
    22040                 22045                 22050             


Glu Glu   Phe Leu Arg Met Thr   Arg Asn Gly Thr Gln   Leu Gln Asn 
    22055                 22060                 22065             


Phe Thr   Leu Asp Arg Ser Ser   Val Leu Val Asp Gly   Tyr Ser Pro 
    22070                 22075                 22080             


Asn Arg   Asn Glu Pro Leu Thr   Gly Asn Ser Asp Leu   Pro Phe Trp 
    22085                 22090                 22095             


Ala Val   Ile Leu Ile Gly Leu   Ala Gly Leu Leu Gly   Leu Ile Thr 
    22100                 22105                 22110             


Cys Leu   Ile Cys Gly Val Leu   Val Thr Thr Arg Arg   Arg Lys Lys 
    22115                 22120                 22125             


Glu Gly   Glu Tyr Asn Val Gln   Gln Gln Cys Pro Gly   Tyr Tyr Gln 
    22130                 22135                 22140             


Ser His   Leu Asp Leu Glu Asp   Leu Gln 
    22145                 22150         



<210> 6594
<211> 104
<212> PRT
<213> Homo sapiens

<400> 6594
Met Leu Val Asn Gly Glu Asn Phe Gly Val Ser Leu Asn Ile Phe Pro
 1               5                  10                  15      
Ser Val Ala Ile Asn Lys Ser Ser Gly Ala Pro Arg Arg Val Pro Ala
            20                  25                  30          
Gln Gly Ser Ile Lys Asp His Thr Ala Gly Leu Arg Leu Thr Ala Leu
        35                  40                  45              
Ser Pro Glu His Gln Ser Pro Ala Glu Ser Gly Asp Asn Thr Ser Ser
    50                  55                  60                  
Leu Gln Arg Gly Thr Ser Pro Pro Ala Ala Thr Ser Leu Arg Leu Leu
65                  70                  75                  80  
Leu Ser Ser Lys Asp Ser Leu Gly Phe Lys Cys His Phe Pro Cys Phe
                85                  90                  95      
Arg Asp Pro Gly Val Leu Ile Ala
            100                 


<210> 6595
<211> 1005
<212> PRT
<213> Homo sapiens

<400> 6595
Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys Glu Pro Cys Leu
 1               5                  10                  15      
His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro Arg Gly Ser Arg
            20                  25                  30          
Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu Glu Val Glu Glu
        35                  40                  45              
Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser Phe Met Asn Arg
    50                  55                  60                  
Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg Gln Ser Pro Asp
65                  70                  75                  80  
Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val Val Cys Ala Phe
                85                  90                  95      
Val Ile Val Val Ala Val Ser Val Ile Met Val Ile Tyr Leu Leu Pro
            100                 105                 110         
Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys Asn Gln Ser Ile
        115                 120                 125             
Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu Phe Pro Trp Ala
    130                 135                 140                 
Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg Tyr Glu Leu Ser
145                 150                 155                 160 
Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly Ser Val Thr Ile
                165                 170                 175     
Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile Leu His Ser Thr
            180                 185                 190         
Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala Val Ser Ser Gln
        195                 200                 205             
Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His Gly Gln Ile Ala
    210                 215                 220                 
Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn Tyr Thr Leu Lys
225                 230                 235                 240 
Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr Gly Phe Tyr Gly
                245                 250                 255     
Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr Phe Ala Ala Thr
            260                 265                 270         
Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro Cys Phe Asp Glu
        275                 280                 285             
Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile Arg Asp Glu Gln
    290                 295                 300                 
Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser Val Val Leu Asp
305                 310                 315                 320 
Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val Lys Met Ser Thr
                325                 330                 335     
Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn Leu Ser Gln Asp
            340                 345                 350         
Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro Glu Asn Ile Gly
        355                 360                 365             
Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu Leu Glu Phe Phe
    370                 375                 380                 
Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys Leu Asp Leu Val
385                 390                 395                 400 
Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn Trp Gly Leu Leu
                405                 410                 415     
Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn Thr Ser Ser Met
            420                 425                 430         
Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His Glu Leu Ala His
        435                 440                 445             
Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp Asn Asp Leu Trp
    450                 455                 460                 
Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe Ser Leu Glu Lys
465                 470                 475                 480 
Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu Asp Ala Arg Phe
                485                 490                 495     
Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His Pro Ile Ser Ser
            500                 505                 510         
Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe Asp Ser Leu Ser
        515                 520                 525             
Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys Thr Tyr Leu Ser
    530                 535                 540                 
Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu His Asn His Ser
545                 550                 555                 560 
Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser Phe Asn Glu Val
                565                 570                 575     
Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys Thr Trp Thr Leu
            580                 585                 590         
Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys Gly Lys Glu Leu
        595                 600                 605             
Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys Pro Glu Ile Gln
    610                 615                 620                 
Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu Ser Tyr Val Thr
625                 630                 635                 640 
Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser Leu Leu Asp Lys
                645                 650                 655     
Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu Trp Val Lys Val
            660                 665                 670         
Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr Ala Asp Asp Asp
        675                 680                 685             
Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro Tyr Val Leu Ser
    690                 695                 700                 
Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe Glu Leu Ala Gly
705                 710                 715                 720 
Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu Ile Asn Tyr Leu
                725                 730                 735     
Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala Leu Phe Gln Thr
            740                 745                 750         
Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr Met Asp Leu Ala
        755                 760                 765             
Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln Asn Gln Ile Gln
    770                 775                 780                 
Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met Arg Glu Leu Arg
785                 790                 795                 800 
Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu Gly Asn Cys Ser
                805                 810                 815     
Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala Ser Asn Gly Thr
            820                 825                 830         
Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe Lys Val Gly Ala
        835                 840                 845             
Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys Tyr Ile Ser Ile
    850                 855                 860                 
Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala Leu Ala Ser Ser
865                 870                 875                 880 
Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser Ser Leu Asn Gly
                885                 890                 895     
Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile Arg Thr Val Gly
            900                 905                 910         
Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe Val Lys Glu Asn
        915                 920                 925             
Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser Tyr Thr Ile Gln
    930                 935                 940                 
Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr Lys Thr His Leu
945                 950                 955                 960 
Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu Ala Thr Phe Arg
                965                 970                 975     
Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln Leu Asn Ile Gln
            980                 985                 990         
Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp Trp Leu
        995                 1000                1005


<210> 6596
<211> 1010
<212> PRT
<213> Homo sapiens

<400> 6596
Ile Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala
 1               5                  10                  15      
Lys Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu
            20                  25                  30          
Pro Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met
        35                  40                  45              
Glu Glu Val Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met
    50                  55                  60                  
Ser Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr
65                  70                  75                  80  
Arg Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met
                85                  90                  95      
Val Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val
            100                 105                 110         
Ile Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys
        115                 120                 125             
Lys Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys
    130                 135                 140                 
Leu Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu
145                 150                 155                 160 
Arg Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg
                165                 170                 175     
Gly Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile
            180                 185                 190         
Ile Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser
        195                 200                 205             
Ala Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr
    210                 215                 220                 
His Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His
225                 230                 235                 240 
Asn Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr
                245                 250                 255     
Tyr Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys
            260                 265                 270         
Tyr Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe
        275                 280                 285             
Pro Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile
    290                 295                 300                 
Ile Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser
305                 310                 315                 320 
Ser Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser
                325                 330                 335     
Val Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys
            340                 345                 350         
Asn Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val
        355                 360                 365             
Pro Glu Asn Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys
    370                 375                 380                 
Leu Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys
385                 390                 395                 400 
Lys Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu
                405                 410                 415     
Asn Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser
            420                 425                 430         
Asn Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala
        435                 440                 445             
His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp
    450                 455                 460                 
Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr
465                 470                 475                 480 
Phe Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe
                485                 490                 495     
Leu Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser
            500                 505                 510         
His Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met
        515                 520                 525             
Phe Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu
    530                 535                 540                 
Lys Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr
545                 550                 555                 560 
Leu His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp
                565                 570                 575     
Ser Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met
            580                 585                 590         
Lys Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys
        595                 600                 605             
Lys Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met
    610                 615                 620                 
Lys Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro
625                 630                 635                 640 
Leu Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val
                645                 650                 655     
Ser Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val
            660                 665                 670         
Leu Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His
        675                 680                 685             
Tyr Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn
    690                 695                 700                 
Pro Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile
705                 710                 715                 720 
Phe Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp
                725                 730                 735     
Leu Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu
            740                 745                 750         
Ala Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly
        755                 760                 765             
Tyr Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu
    770                 775                 780                 
Gln Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser
785                 790                 795                 800 
Met Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn
                805                 810                 815     
Leu Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met
            820                 825                 830         
Ala Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val
        835                 840                 845             
Phe Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly
    850                 855                 860                 
Lys Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu
865                 870                 875                 880 
Ala Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys
                885                 890                 895     
Ser Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile
            900                 905                 910         
Ile Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp
        915                 920                 925             
Phe Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly
    930                 935                 940                 
Ser Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser
945                 950                 955                 960 
Thr Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser
                965                 970                 975     
Glu Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile
            980                 985                 990         
Gln Leu Asn Ile Gln Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp
        995                 1000                1005            
Trp Leu
    1010


<210> 6597
<211> 1025
<212> PRT
<213> Homo sapiens

<400> 6597
Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile
 1               5                  10                  15      
Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys
            20                  25                  30          
Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro
        35                  40                  45              
Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu
    50                  55                  60                  
Glu Val Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser
65                  70                  75                  80  
Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg
                85                  90                  95      
Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val
            100                 105                 110         
Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile
        115                 120                 125             
Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys
    130                 135                 140                 
Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu
145                 150                 155                 160 
Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg
                165                 170                 175     
Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly
            180                 185                 190         
Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile
        195                 200                 205             
Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala
    210                 215                 220                 
Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His
225                 230                 235                 240 
Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn
                245                 250                 255     
Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr
            260                 265                 270         
Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr
        275                 280                 285             
Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro
    290                 295                 300                 
Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile
305                 310                 315                 320 
Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser
                325                 330                 335     
Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val
            340                 345                 350         
Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn
        355                 360                 365             
Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro
    370                 375                 380                 
Glu Asn Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu
385                 390                 395                 400 
Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys
                405                 410                 415     
Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn
            420                 425                 430         
Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn
        435                 440                 445             
Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His
    450                 455                 460                 
Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp
465                 470                 475                 480 
Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe
                485                 490                 495     
Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu
            500                 505                 510         
Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His
        515                 520                 525             
Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe
    530                 535                 540                 
Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys
545                 550                 555                 560 
Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu
                565                 570                 575     
His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser
            580                 585                 590         
Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys
        595                 600                 605             
Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys
    610                 615                 620                 
Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys
625                 630                 635                 640 
Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu
                645                 650                 655     
Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser
            660                 665                 670         
Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu
        675                 680                 685             
Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr
    690                 695                 700                 
Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro
705                 710                 715                 720 
Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe
                725                 730                 735     
Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu
            740                 745                 750         
Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala
        755                 760                 765             
Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr
    770                 775                 780                 
Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln
785                 790                 795                 800 
Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met
                805                 810                 815     
Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu
            820                 825                 830         
Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala
        835                 840                 845             
Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe
    850                 855                 860                 
Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys
865                 870                 875                 880 
Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala
                885                 890                 895     
Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser
            900                 905                 910         
Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile
        915                 920                 925             
Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe
    930                 935                 940                 
Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser
945                 950                 955                 960 
Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr
                965                 970                 975     
Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu
            980                 985                 990         
Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln
        995                 1000                1005            
Leu Asn Ile Gln Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp Trp
    1010                1015                1020                
Leu
1025


<210> 6598
<211> 1979
<212> PRT
<213> Homo sapiens

<400> 6598
Met Ser Ser Trp Leu Gly Gly Leu Gly Ser Gly Leu Gly Gln Ser Leu
 1               5                  10                  15      
Gly Gln Val Gly Gly Ser Leu Ala Ser Leu Thr Gly Gln Ile Ser Asn
            20                  25                  30          
Phe Thr Lys Asp Met Leu Met Glu Gly Thr Glu Glu Val Glu Ala Glu
        35                  40                  45              
Leu Pro Asp Ser Arg Thr Lys Glu Ile Glu Ala Ile His Ala Ile Leu
    50                  55                  60                  
Arg Ser Glu Asn Glu Arg Leu Lys Lys Leu Cys Thr Asp Leu Glu Glu
65                  70                  75                  80  
Lys His Glu Ala Ser Glu Ile Gln Ile Lys Gln Gln Ser Thr Ser Tyr
                85                  90                  95      
Arg Asn Gln Leu Gln Gln Lys Glu Val Glu Ile Ser His Leu Lys Ala
            100                 105                 110         
Arg Gln Ile Ala Leu Gln Asp Gln Leu Leu Lys Leu Gln Ser Ala Ala
        115                 120                 125             
Gln Ser Val Pro Ser Gly Ala Gly Val Pro Ala Thr Thr Ala Ser Ser
    130                 135                 140                 
Ser Phe Ala Tyr Gly Ile Ser His His Pro Ser Ala Phe His Asp Asp
145                 150                 155                 160 
Asp Met Asp Phe Gly Asp Ile Ile Ser Ser Gln Gln Glu Ile Asn Arg
                165                 170                 175     
Leu Ser Asn Glu Val Ser Arg Leu Glu Ser Glu Val Gly His Trp Arg
            180                 185                 190         
His Ile Ala Gln Thr Ser Lys Ala Gln Gly Thr Asp Asn Ser Asp Gln
        195                 200                 205             
Ser Glu Ile Cys Lys Leu Gln Asn Ile Ile Lys Glu Leu Lys Gln Asn
    210                 215                 220                 
Arg Ser Gln Glu Ile Asp Asp His Gln His Glu Met Ser Val Leu Gln
225                 230                 235                 240 
Asn Ala His Gln Gln Lys Leu Thr Glu Ile Ser Arg Arg His Arg Glu
                245                 250                 255     
Glu Leu Ser Asp Tyr Glu Glu Arg Ile Glu Glu Leu Glu Asn Leu Leu
            260                 265                 270         
Gln Gln Gly Gly Ser Gly Val Ile Glu Thr Asp Leu Ser Lys Ile Tyr
        275                 280                 285             
Glu Met Gln Lys Thr Ile Gln Val Leu Gln Ile Glu Lys Val Glu Ser
    290                 295                 300                 
Thr Lys Lys Met Glu Gln Leu Glu Asp Lys Ile Lys Asp Ile Asn Lys
305                 310                 315                 320 
Lys Leu Ser Ser Ala Glu Asn Asp Arg Asp Ile Leu Arg Arg Glu Gln
                325                 330                 335     
Glu Gln Leu Asn Val Glu Lys Arg Gln Ile Met Glu Glu Cys Glu Asn
            340                 345                 350         
Leu Lys Leu Glu Cys Ser Lys Leu Gln Pro Ser Ala Val Lys Gln Ser
        355                 360                 365             
Asp Thr Met Thr Glu Lys Glu Arg Ile Leu Ala Gln Ser Ala Ser Val
    370                 375                 380                 
Glu Glu Val Phe Arg Leu Gln Gln Ala Leu Ser Asp Ala Glu Asn Glu
385                 390                 395                 400 
Ile Met Arg Leu Ser Ser Leu Asn Gln Asp Asn Ser Leu Ala Glu Asp
                405                 410                 415     
Asn Leu Lys Leu Lys Met Arg Ile Glu Val Leu Glu Lys Glu Lys Ser
            420                 425                 430         
Leu Leu Ser Gln Glu Lys Glu Glu Leu Gln Met Ser Leu Leu Lys Leu
        435                 440                 445             
Asn Asn Glu Tyr Glu Val Ile Lys Ser Thr Ala Thr Arg Asp Ile Ser
    450                 455                 460                 
Leu Asp Ser Glu Leu His Asp Leu Arg Leu Asn Leu Glu Ala Lys Glu
465                 470                 475                 480 
Gln Glu Leu Asn Gln Ser Ile Ser Glu Lys Glu Thr Leu Ile Ala Glu
                485                 490                 495     
Ile Glu Glu Leu Asp Arg Gln Asn Gln Glu Ala Thr Lys His Met Ile
            500                 505                 510         
Leu Ile Lys Asp Gln Leu Ser Lys Gln Gln Asn Glu Gly Asp Ser Ile
        515                 520                 525             
Ile Ser Lys Leu Lys Gln Asp Leu Asn Asp Glu Lys Lys Arg Val His
    530                 535                 540                 
Gln Leu Glu Asp Asp Lys Met Asp Ile Thr Lys Glu Leu Asp Val Gln
545                 550                 555                 560 
Lys Glu Lys Leu Ile Gln Ser Glu Val Ala Leu Asn Asp Leu His Leu
                565                 570                 575     
Thr Lys Gln Lys Leu Glu Asp Lys Val Glu Asn Leu Val Asp Gln Leu
            580                 585                 590         
Asn Lys Ser Gln Glu Ser Asn Val Ser Ile Gln Lys Glu Asn Leu Glu
        595                 600                 605             
Leu Lys Glu His Ile Arg Gln Asn Glu Glu Glu Leu Ser Arg Ile Arg
    610                 615                 620                 
Asn Glu Leu Met Gln Ser Leu Asn Gln Asp Ser Asn Ser Asn Phe Lys
625                 630                 635                 640 
Asp Thr Leu Leu Lys Glu Arg Glu Ala Glu Val Arg Asn Leu Lys Gln
                645                 650                 655     
Asn Leu Ser Glu Leu Glu Gln Leu Asn Glu Asn Leu Lys Lys Val Ala
            660                 665                 670         
Phe Asp Val Lys Met Glu Asn Glu Lys Leu Val Leu Ala Cys Glu Asp
        675                 680                 685             
Val Arg His Gln Leu Glu Glu Cys Leu Ala Gly Asn Asn Gln Leu Ser
    690                 695                 700                 
Leu Glu Lys Asn Thr Ile Val Glu Thr Leu Lys Met Glu Lys Gly Glu
705                 710                 715                 720 
Ile Glu Ala Glu Leu Cys Trp Ala Lys Lys Arg Leu Leu Glu Glu Ala
                725                 730                 735     
Asn Lys Tyr Glu Lys Thr Ile Glu Glu Leu Ser Asn Ala Arg Asn Leu
            740                 745                 750         
Asn Thr Ser Ala Leu Gln Leu Glu His Glu His Leu Ile Lys Leu Asn
        755                 760                 765             
Gln Lys Lys Asp Met Glu Ile Ala Glu Leu Lys Lys Asn Ile Glu Gln
    770                 775                 780                 
Met Asp Thr Asp His Lys Glu Thr Lys Asp Val Leu Ser Ser Ser Leu
785                 790                 795                 800 
Glu Glu Gln Lys Gln Leu Thr Gln Leu Ile Asn Lys Lys Glu Ile Phe
                805                 810                 815     
Ile Glu Lys Leu Lys Glu Arg Ser Ser Lys Leu Gln Glu Glu Leu Asp
            820                 825                 830         
Lys Tyr Ser Gln Ala Leu Arg Lys Asn Glu Ile Leu Arg Gln Thr Ile
        835                 840                 845             
Glu Glu Lys Asp Arg Ser Leu Gly Ser Met Lys Glu Glu Asn Asn His
    850                 855                 860                 
Leu Gln Glu Glu Leu Glu Arg Leu Arg Glu Glu Gln Ser Arg Thr Ala
865                 870                 875                 880 
Pro Val Ala Asp Pro Lys Thr Leu Asp Ser Val Thr Glu Leu Ala Ser
                885                 890                 895     
Glu Val Ser Gln Leu Asn Thr Ile Lys Glu His Leu Glu Glu Glu Ile
            900                 905                 910         
Lys His His Gln Lys Ile Ile Glu Asp Gln Asn Gln Ser Lys Met Gln
        915                 920                 925             
Leu Leu Gln Ser Leu Gln Glu Gln Lys Lys Glu Met Asp Glu Phe Arg
    930                 935                 940                 
Tyr Gln His Glu Gln Met Asn Ala Thr His Thr Gln Leu Phe Leu Glu
945                 950                 955                 960 
Lys Asp Glu Glu Ile Lys Ser Leu Gln Lys Thr Ile Glu Gln Ile Lys
                965                 970                 975     
Thr Gln Leu His Glu Glu Arg Gln Asp Ile Gln Thr Asp Asn Ser Asp
            980                 985                 990         
Ile Phe Gln Glu Thr Lys Val Gln Ser Leu Asn Ile Glu Asn Gly Ser
        995                 1000                1005            
Glu Lys His Asp Leu Ser Lys Ala Glu Thr Glu Arg Leu Val Lys Gly
    1010                1015                1020                
Ile Lys Glu Arg Glu Leu Glu Ile Lys Leu Leu Asn Glu Lys Asn Ile
1025                1030                1035                1040
Ser Leu Thr Lys Gln Ile Asp Gln Leu Ser Lys Asp Glu Val Gly Lys
                1045                1050                1055    
Leu Thr Gln Ile Ile Gln Gln Lys Asp Leu Glu Ile Gln Ala Leu His
            1060                1065                1070        
Ala Arg Ile Ser Ser Thr Ser His Thr Gln Asp Val Val Tyr Leu Gln
        1075                1080                1085            
Gln Gln Leu Gln Ala Tyr Ala Met Glu Arg Glu Lys Val Phe Ala Val
    1090                1095                1100                
Leu Asn Glu Lys Thr Arg Glu Asn Ser His Leu Lys Thr Glu Tyr His
1105                1110                1115                1120
Lys Met Met Asp Ile Val Ala Ala Lys Glu Ala Ala Leu Ile Lys Leu
                1125                1130                1135    
Gln Asp Glu Asn Lys Lys Leu Ser Thr Arg Phe Glu Ser Ser Gly Gln
            1140                1145                1150        
Asp Met Phe Arg Glu Thr Ile Gln Asn Leu Ser Arg Ile Ile Arg Glu
        1155                1160                1165            
Lys Asp Ile Glu Ile Asp Ala Leu Ser Gln Lys Cys Gln Thr Leu Leu
    1170                1175                1180                
Ala Val Leu Gln Thr Ser Ser Thr Gly Asn Glu Ala Gly Gly Val Asn
1185                1190                1195                1200
Ser His Gln Phe Glu Glu Leu Leu Gln Glu Arg Asp Lys Leu Lys Gln
                1205                1210                1215    
Gln Val Lys Lys Met Glu Glu Trp Lys Gln Gln Val Met Thr Thr Val
            1220                1225                1230        
Gln Asn Met Gln His Glu Ser Ala Gln Leu Gln Glu Glu Leu His Gln
        1235                1240                1245            
Leu Gln Ala Gln Val Leu Val Asp Ser Asp Asn Asn Ser Lys Leu Gln
    1250                1255                1260                
Val Asp Tyr Thr Gly Leu Ile Gln Ser Tyr Glu Gln Asn Glu Thr Lys
1265                1270                1275                1280
Leu Lys Asn Phe Gly Gln Glu Leu Ala Gln Val Gln His Ser Ile Gly
                1285                1290                1295    
Gln Leu Cys Asn Thr Lys Asp Leu Leu Leu Gly Lys Leu Asp Ile Ile
            1300                1305                1310        
Ser Pro Gln Leu Ser Ser Ala Ser Leu Leu Thr Pro Gln Ser Ala Glu
        1315                1320                1325            
Cys Leu Arg Ala Ser Lys Ser Glu Val Leu Ser Glu Ser Ser Glu Leu
    1330                1335                1340                
Leu Gln Gln Glu Leu Glu Glu Leu Arg Lys Ser Leu Gln Glu Lys Asp
1345                1350                1355                1360
Ala Thr Ile Arg Thr Leu Gln Glu Asn Asn His Arg Leu Ser Asp Ser
                1365                1370                1375    
Ile Ala Ala Thr Ser Glu Leu Glu Arg Lys Glu His Glu Gln Thr Asp
            1380                1385                1390        
Ser Glu Ile Lys Gln Leu Lys Glu Lys Gln Asp Val Leu Gln Lys Leu
        1395                1400                1405            
Leu Lys Glu Lys Asp Leu Leu Ile Lys Ala Lys Ser Asp Gln Leu Leu
    1410                1415                1420                
Ser Ser Asn Glu Asn Phe Thr Asn Lys Val Asn Glu Asn Glu Leu Leu
1425                1430                1435                1440
Arg Gln Ala Val Thr Asn Leu Lys Glu Arg Ile Leu Ile Leu Glu Met
                1445                1450                1455    
Asp Ile Gly Lys Leu Lys Gly Glu Asn Glu Lys Ile Val Glu Thr Tyr
            1460                1465                1470        
Arg Gly Lys Glu Thr Glu Tyr Gln Ala Leu Gln Glu Thr Asn Met Lys
        1475                1480                1485            
Phe Ser Met Met Leu Arg Glu Lys Glu Phe Glu Cys His Ser Met Lys
    1490                1495                1500                
Glu Lys Ala Leu Ala Phe Glu Gln Leu Leu Lys Glu Lys Glu Gln Gly
1505                1510                1515                1520
Lys Thr Gly Glu Leu Asn Gln Leu Leu Asn Ala Val Lys Ser Met Gln
                1525                1530                1535    
Glu Lys Thr Val Val Phe Gln Gln Glu Arg Asp Gln Val Met Leu Ala
            1540                1545                1550        
Leu Lys Gln Lys Gln Met Glu Asn Thr Ala Leu Gln Asn Glu Val Gln
        1555                1560                1565            
Arg Leu Arg Asp Lys Glu Phe Arg Ser Asn Gln Glu Leu Glu Arg Leu
    1570                1575                1580                
Arg Asn His Leu Leu Glu Ser Glu Asp Ser Tyr Thr Arg Glu Ala Leu
1585                1590                1595                1600
Ala Ala Glu Asp Arg Glu Ala Lys Leu Arg Lys Lys Val Thr Val Leu
                1605                1610                1615    
Glu Glu Lys Leu Val Ser Ser Ser Asn Ala Met Glu Asn Ala Ser His
            1620                1625                1630        
Gln Ala Ser Val Gln Val Glu Ser Leu Gln Glu Gln Leu Asn Val Val
        1635                1640                1645            
Ser Lys Gln Arg Asp Glu Thr Ala Leu Gln Leu Ser Val Ser Gln Glu
    1650                1655                1660                
Gln Val Lys Gln Tyr Ala Leu Ser Leu Ala Asn Leu Gln Met Val Leu
1665                1670                1675                1680
Glu His Phe Gln Gln Glu Glu Lys Ala Met Tyr Ser Ala Glu Leu Glu
                1685                1690                1695    
Lys Gln Lys Gln Leu Ile Ala Glu Trp Lys Lys Asn Ala Glu Asn Leu
            1700                1705                1710        
Glu Gly Lys Val Ile Ser Leu Gln Glu Cys Leu Asp Glu Ala Asn Ala
        1715                1720                1725            
Ala Leu Asp Ser Ala Ser Arg Leu Thr Glu Gln Leu Asp Val Lys Glu
    1730                1735                1740                
Glu Gln Ile Glu Glu Leu Lys Arg Gln Asn Glu Leu Arg Gln Glu Met
1745                1750                1755                1760
Leu Asp Asp Val Gln Lys Lys Leu Met Ser Leu Ala Asn Ser Ser Glu
                1765                1770                1775    
Gly Lys Val Asp Lys Val Leu Met Arg Asn Leu Phe Ile Gly His Phe
            1780                1785                1790        
His Thr Pro Lys Asn Gln Arg His Glu Val Leu Arg Leu Met Gly Ser
        1795                1800                1805            
Ile Leu Gly Val Arg Arg Glu Glu Met Glu Gln Leu Phe His Asp Asp
    1810                1815                1820                
Gln Gly Ser Val Thr Arg Trp Met Thr Gly Trp Leu Gly Gly Gly Ser
1825                1830                1835                1840
Lys Ser Val Pro Asn Thr Pro Leu Arg Pro Asn Gln Gln Ser Val Val
                1845                1850                1855    
Asn Ser Ser Phe Ser Glu Leu Phe Val Lys Phe Leu Glu Thr Glu Ser
            1860                1865                1870        
His Pro Ser Ile Pro Pro Pro Lys Leu Ser Val His Asp Met Lys Pro
        1875                1880                1885            
Leu Asp Ser Pro Gly Arg Arg Lys Arg Asp Thr Asn Ala Pro Glu Ser
    1890                1895                1900                
Phe Lys Asp Thr Ala Glu Ser Arg Ser Gly Arg Arg Thr Asp Val Asn
1905                1910                1915                1920
Pro Phe Leu Ala Pro Arg Ser Ala Ala Val Pro Leu Ile Asn Pro Ala
                1925                1930                1935    
Gly Leu Gly Pro Gly Gly Pro Gly His Leu Leu Leu Lys Pro Ile Ser
            1940                1945                1950        
Asp Val Leu Pro Thr Phe Thr Pro Leu Pro Ala Leu Pro Asp Asn Ser
        1955                1960                1965            
Ala Gly Val Val Leu Lys Asp Leu Leu Lys Gln
    1970                1975                


<210> 6599
<211> 318
<212> PRT
<213> Homo sapiens

<400> 6599
Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu
 1               5                  10                  15      
Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala
            20                  25                  30          
Arg Trp Arg Ala Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu
        35                  40                  45              
Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn
    50                  55                  60                  
Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys
65                  70                  75                  80  
Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu
                85                  90                  95      
Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser
            100                 105                 110         
His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro
        115                 120                 125             
Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys
    130                 135                 140                 
Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser
145                 150                 155                 160 
Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser
                165                 170                 175     
Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn
            180                 185                 190         
Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp
        195                 200                 205             
Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile
    210                 215                 220                 
Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu
225                 230                 235                 240 
Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln
                245                 250                 255     
Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val
            260                 265                 270         
Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala
        275                 280                 285             
Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu
    290                 295                 300                 
Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu
305                 310                 315             


<210> 6600
<211> 334
<212> PRT
<213> Homo sapiens

<400> 6600
Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp
            20                  25                  30          
Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly
    50                  55                  60                  
Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg
                85                  90                  95      
Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu
            100                 105                 110         
Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln
                165                 170                 175     
Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp
        195                 200                 205             
Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val
225                 230                 235                 240 
Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser
                245                 250                 255     
Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser
            260                 265                 270         
Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly
        275                 280                 285             
Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly
    290                 295                 300                 
Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn
305                 310                 315                 320 
Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val
                325                 330                 


<210> 6601
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 6601
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445             
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460                 
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
            500                 505                 510         
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
        515                 520                 525             
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
    530                 535                 540                 
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545                 550                 555                 560 
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
                565                 570                 575     
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
            580                 585                 590         
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
        595                 600                 605             
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
    610                 615                 620                 
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625                 630                 635                 640 
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser
                645                 650                 655     
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
            660                 665                 670         
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
        675                 680                 685             
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
    690                 695                 700                 
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705                 710                 715                 720 
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
                725                 730                 735     
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
            740                 745                 750         
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
        755                 760                 765             
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
    770                 775                 780                 
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785                 790                 795                 800 
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
                805                 810                 815     
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
            820                 825                 830         
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
        835                 840                 845             
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
    850                 855                 860                 
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865                 870                 875                 880 
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
                885                 890                 895     
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
            900                 905                 910         
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
        915                 920                 925             
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
    930                 935                 940                 
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met
945                 950                 955                 960 
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
                965                 970                 975     
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
            980                 985                 990         
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
        995                 1000                1005            
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu
    1010                1015                1020                
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly
1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly
                1045                1050                1055    
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg
            1060                1065                1070        
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly
        1075                1080                1085            
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His
    1090                1095                1100                
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu
1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln
                1125                1130                1135    
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro
            1140                1145                1150        
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu
        1155                1160                1165            
Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val
    1170                1175                1180                
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln
1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala
                1205                1210                1215    
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala
            1220                1225                1230        
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
        1235                1240                1245            
Leu Gly Leu Asp Val Pro Val
    1250                1255


<210> 6602
<211> 1506
<212> PRT
<213> Homo sapiens

<400> 6602
Met Ala Ser Ala Ser Gly Pro Thr Val Gly Ser Arg Pro Trp Trp Leu
 1               5                  10                  15      
Arg Ala Ser Glu Arg Pro Ser Ala Pro Ser Ala Met Ala Lys Arg Ser
            20                  25                  30          
Arg Gly Pro Gly Arg Arg Cys Leu Leu Ala Leu Val Leu Phe Cys Ala
        35                  40                  45              
Trp Gly Thr Leu Ala Val Val Ala Gln Lys Pro Gly Ala Gly Cys Pro
    50                  55                  60                  
Ser Arg Cys Leu Cys Phe Arg Thr Thr Val Arg Cys Met His Leu Leu
65                  70                  75                  80  
Leu Glu Ala Val Pro Ala Val Ala Pro Gln Thr Ser Ile Leu Asp Leu
                85                  90                  95      
Arg Phe Asn Arg Ile Arg Glu Ile Gln Pro Gly Ala Phe Arg Arg Leu
            100                 105                 110         
Arg Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn Gln Ile Lys Arg Ile
        115                 120                 125             
Pro Ser Gly Ala Phe Glu Asp Leu Glu Asn Leu Lys Tyr Leu Tyr Leu
    130                 135                 140                 
Tyr Lys Asn Glu Ile Gln Ser Ile Asp Arg Gln Ala Phe Lys Gly Leu
145                 150                 155                 160 
Ala Ser Leu Glu Gln Leu Tyr Leu His Phe Asn Gln Ile Glu Thr Leu
                165                 170                 175     
Asp Pro Asp Ser Phe Gln His Leu Pro Lys Leu Glu Arg Leu Phe Leu
            180                 185                 190         
His Asn Asn Arg Ile Thr His Leu Val Pro Gly Thr Phe Asn His Leu
        195                 200                 205             
Glu Ser Met Lys Arg Leu Arg Leu Asp Ser Asn Thr Leu His Cys Asp
    210                 215                 220                 
Cys Glu Ile Leu Trp Leu Ala Asp Leu Leu Lys Thr Tyr Ala Glu Ser
225                 230                 235                 240 
Gly Asn Ala Gln Ala Ala Ala Ile Cys Glu Tyr Pro Arg Arg Ile Gln
                245                 250                 255     
Gly Arg Ser Val Ala Thr Ile Thr Pro Glu Glu Leu Asn Cys Glu Arg
            260                 265                 270         
Pro Arg Ile Thr Ser Glu Pro Gln Asp Ala Asp Val Thr Ser Gly Asn
        275                 280                 285             
Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile
    290                 295                 300                 
Ile Trp Leu Arg Asn Asn Asn Glu Leu Ser Met Lys Thr Asp Ser Arg
305                 310                 315                 320 
Leu Asn Leu Leu Asp Asp Gly Thr Leu Met Ile Gln Asn Thr Gln Glu
                325                 330                 335     
Thr Asp Gln Gly Ile Tyr Gln Cys Met Ala Lys Asn Val Ala Gly Glu
            340                 345                 350         
Val Lys Thr Gln Glu Val Thr Leu Arg Tyr Phe Gly Ser Pro Ala Arg
        355                 360                 365             
Pro Thr Phe Val Ile Gln Pro Gln Asn Thr Glu Val Leu Val Gly Glu
    370                 375                 380                 
Ser Val Thr Leu Glu Cys Ser Ala Thr Gly His Pro Pro Pro Arg Ile
385                 390                 395                 400 
Ser Trp Thr Arg Gly Asp Arg Thr Pro Leu Pro Val Asp Pro Arg Val
                405                 410                 415     
Asn Ile Thr Pro Ser Gly Gly Leu Tyr Ile Gln Asn Val Val Gln Gly
            420                 425                 430         
Asp Ser Gly Glu Tyr Ala Cys Ser Ala Thr Asn Asn Ile Asp Ser Val
        435                 440                 445             
His Ala Thr Ala Phe Ile Ile Val Gln Ala Leu Pro Gln Phe Thr Val
    450                 455                 460                 
Thr Pro Gln Asp Arg Val Val Ile Glu Gly Gln Thr Val Asp Phe Gln
465                 470                 475                 480 
Cys Glu Ala Lys Gly Asn Pro Pro Pro Val Ile Ala Trp Thr Lys Gly
                485                 490                 495     
Gly Ser Gln Leu Ser Val Asp Arg Arg His Leu Val Leu Ser Ser Gly
            500                 505                 510         
Thr Leu Arg Ile Ser Gly Val Ala Leu His Asp Gln Gly Gln Tyr Glu
        515                 520                 525             
Cys Gln Ala Val Asn Ile Ile Gly Ser Gln Lys Val Val Ala His Leu
    530                 535                 540                 
Thr Val Gln Pro Arg Val Thr Pro Val Phe Ala Ser Ile Pro Ser Asp
545                 550                 555                 560 
Thr Thr Val Glu Val Gly Ala Asn Val Gln Leu Pro Cys Ser Ser Gln
                565                 570                 575     
Gly Glu Pro Glu Pro Ala Ile Thr Trp Asn Lys Asp Gly Val Gln Val
            580                 585                 590         
Thr Glu Ser Gly Lys Phe His Ile Ser Pro Glu Gly Phe Leu Thr Ile
        595                 600                 605             
Asn Asp Val Gly Pro Ala Asp Ala Gly Arg Tyr Glu Cys Val Ala Arg
    610                 615                 620                 
Asn Thr Ile Gly Ser Ala Ser Val Ser Met Val Leu Ser Val Asn Val
625                 630                 635                 640 
Pro Asp Val Ser Arg Asn Gly Asp Pro Phe Val Ala Thr Ser Ile Val
                645                 650                 655     
Glu Ala Ile Ala Thr Val Asp Arg Ala Ile Asn Ser Thr Arg Thr His
            660                 665                 670         
Leu Phe Asp Ser Arg Pro Arg Ser Pro Asn Asp Leu Leu Ala Leu Phe
        675                 680                 685             
Arg Tyr Pro Arg Asp Pro Tyr Thr Val Glu Gln Ala Arg Ala Gly Glu
    690                 695                 700                 
Ile Phe Glu Arg Thr Leu Gln Leu Ile Gln Glu His Val Gln His Gly
705                 710                 715                 720 
Leu Met Val Asp Leu Asn Gly Thr Ser Tyr His Tyr Asn Asp Leu Val
                725                 730                 735     
Ser Pro Gln Tyr Leu Asn Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala
            740                 745                 750         
His Arg Arg Val Asn Asn Cys Ser Asp Met Cys Phe His Gln Lys Tyr
        755                 760                 765             
Arg Thr His Asp Gly Thr Cys Asn Asn Leu Gln His Pro Met Trp Gly
    770                 775                 780                 
Ala Ser Leu Thr Ala Phe Glu Arg Leu Leu Lys Ser Val Tyr Glu Asn
785                 790                 795                 800 
Gly Phe Asn Thr Pro Arg Gly Ile Asn Pro His Arg Leu Tyr Asn Gly
                805                 810                 815     
His Ala Leu Pro Met Pro Arg Leu Val Ser Thr Thr Leu Ile Gly Thr
            820                 825                 830         
Glu Thr Val Thr Pro Asp Glu Gln Phe Thr His Met Leu Met Gln Trp
        835                 840                 845             
Gly Gln Phe Leu Asp His Asp Leu Asp Ser Thr Val Val Ala Leu Ser
    850                 855                 860                 
Gln Ala Arg Phe Ser Asp Gly Gln His Cys Ser Asn Val Cys Ser Asn
865                 870                 875                 880 
Asp Pro Pro Cys Phe Ser Val Met Ile Pro Pro Asn Asp Ser Arg Ala
                885                 890                 895     
Arg Ser Gly Ala Arg Cys Met Phe Phe Val Arg Ser Ser Pro Val Cys
            900                 905                 910         
Gly Ser Gly Met Thr Ser Leu Leu Met Asn Ser Val Tyr Pro Arg Glu
        915                 920                 925             
Gln Ile Asn Gln Leu Thr Ser Tyr Ile Asp Ala Ser Asn Val Tyr Gly
    930                 935                 940                 
Ser Thr Glu His Glu Ala Arg Ser Ile Arg Asp Leu Ala Ser His Arg
945                 950                 955                 960 
Gly Leu Leu Arg Gln Gly Ile Val Gln Arg Ser Gly Lys Pro Leu Leu
                965                 970                 975     
Pro Phe Ala Thr Gly Pro Pro Thr Glu Cys Met Arg Asp Glu Asn Glu
            980                 985                 990         
Ser Pro Ile Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu Gln
        995                 1000                1005            
Leu Gly Leu Thr Ser Met His Thr Leu Trp Phe Arg Glu His Asn Arg
    1010                1015                1020                
Ile Ala Thr Glu Leu Leu Lys Leu Asn Pro His Trp Asp Gly Asp Thr
1025                1030                1035                1040
Ile Tyr Tyr Glu Thr Arg Lys Ile Val Gly Ala Glu Ile Gln His Ile
                1045                1050                1055    
Thr Tyr Gln His Trp Leu Pro Lys Ile Leu Gly Glu Val Gly Met Arg
            1060                1065                1070        
Thr Leu Gly Glu Tyr His Gly Tyr Asp Pro Gly Ile Asn Ala Gly Ile
        1075                1080                1085            
Phe Asn Ala Phe Ala Thr Ala Ala Phe Arg Phe Gly His Thr Leu Val
    1090                1095                1100                
Asn Pro Leu Leu Tyr Arg Leu Asp Glu Asn Phe Gln Pro Ile Ala Gln
1105                1110                1115                1120
Asp His Leu Pro Leu His Lys Ala Phe Phe Ser Pro Phe Arg Ile Val
                1125                1130                1135    
Asn Glu Gly Gly Ile Asp Pro Leu Leu Arg Gly Leu Phe Gly Val Ala
            1140                1145                1150        
Gly Lys Met Arg Val Pro Ser Gln Leu Leu Asn Thr Glu Leu Thr Glu
        1155                1160                1165            
Arg Leu Phe Ser Met Ala His Thr Val Ala Leu Asp Leu Ala Ala Ile
    1170                1175                1180                
Asn Ile Gln Arg Gly Arg Asp His Gly Ile Pro Pro Tyr His Asp Tyr
1185                1190                1195                1200
Arg Val Tyr Cys Asn Leu Ser Ala Ala His Thr Phe Glu Asp Leu Lys
                1205                1210                1215    
Asn Glu Ile Lys Asn Pro Glu Ile Arg Glu Lys Leu Lys Arg Leu Tyr
            1220                1225                1230        
Gly Ser Thr Leu Asn Ile Asp Leu Phe Pro Ala Leu Val Val Glu Asp
        1235                1240                1245            
Leu Val Pro Gly Ser Arg Leu Gly Pro Thr Leu Met Cys Leu Leu Ser
    1250                1255                1260                
Thr Gln Phe Lys Arg Leu Arg Asp Gly Asp Arg Leu Trp Tyr Glu Asn
1265                1270                1275                1280
Pro Gly Val Phe Ser Pro Ala Gln Leu Thr Gln Ile Lys Gln Thr Ser
                1285                1290                1295    
Leu Ala Arg Ile Leu Cys Asp Asn Ala Asp Asn Ile Thr Arg Val Gln
            1300                1305                1310        
Ser Asp Val Phe Arg Val Ala Glu Phe Pro His Gly Tyr Gly Ser Cys
        1315                1320                1325            
Asp Glu Ile Pro Arg Val Asp Leu Arg Val Trp Gln Asp Cys Cys Glu
    1330                1335                1340                
Asp Cys Arg Thr Arg Gly Gln Phe Asn Ala Phe Ser Tyr His Phe Arg
1345                1350                1355                1360
Gly Arg Arg Ser Leu Glu Phe Ser Tyr Gln Glu Asp Lys Pro Thr Lys
                1365                1370                1375    
Lys Thr Arg Pro Arg Lys Ile Pro Ser Val Gly Arg Gln Gly Glu His
            1380                1385                1390        
Leu Ser Asn Ser Thr Ser Ala Phe Ser Thr Arg Ser Asp Ala Ser Gly
        1395                1400                1405            
Thr Asn Asp Phe Arg Glu Phe Val Leu Glu Met Gln Lys Thr Ile Thr
    1410                1415                1420                
Asp Leu Arg Thr Gln Ile Lys Lys Leu Glu Ser Arg Leu Ser Thr Thr
1425                1430                1435                1440
Glu Cys Val Asp Ala Gly Gly Glu Ser His Ala Asn Asn Thr Lys Trp
                1445                1450                1455    
Lys Lys Asp Ala Cys Thr Ile Cys Glu Cys Lys Asp Gly Gln Val Thr
            1460                1465                1470        
Cys Phe Val Glu Ala Cys Pro Pro Ala Thr Cys Ala Val Pro Val Asn
        1475                1480                1485            
Ile Pro Gly Ala Cys Cys Pro Val Cys Leu Gln Lys Arg Ala Glu Glu
    1490                1495                1500                
Lys Pro
1505    


<210> 6603
<211> 293
<212> PRT
<213> Homo sapiens

<400> 6603
Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile
 1               5                  10                  15      
Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp
            20                  25                  30          
Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln
        35                  40                  45              
Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser
    50                  55                  60                  
Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp
65                  70                  75                  80  
Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val
                85                  90                  95      
Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys
            100                 105                 110         
Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu
        115                 120                 125             
Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly
    130                 135                 140                 
Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn
145                 150                 155                 160 
Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser
                165                 170                 175     
His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr
            180                 185                 190         
Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn
        195                 200                 205             
Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln
    210                 215                 220                 
Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser
225                 230                 235                 240 
Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln
                245                 250                 255     
Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro
            260                 265                 270         
Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr
        275                 280                 285             
Ile Gln Ala Asn Ser
    290             


<210> 6604
<211> 560
<212> PRT
<213> Homo sapiens

<400> 6604
Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg
 1               5                  10                  15      
Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu
            20                  25                  30          
Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser
        35                  40                  45              
Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg
    50                  55                  60                  
Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala
65                  70                  75                  80  
Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe
                85                  90                  95      
Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly
            100                 105                 110         
Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala
        115                 120                 125             
Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly
    130                 135                 140                 
Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys
145                 150                 155                 160 
Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val
                165                 170                 175     
Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val
            180                 185                 190         
Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met
        195                 200                 205             
Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala
    210                 215                 220                 
Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val
225                 230                 235                 240 
Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu
                245                 250                 255     
Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His
            260                 265                 270         
Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn
        275                 280                 285             
Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val
    290                 295                 300                 
Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro
305                 310                 315                 320 
Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr
                325                 330                 335     
Pro Ser Leu Gly Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile
            340                 345                 350         
Pro Asp Glu Asn Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr
        355                 360                 365             
Ile Thr Ile Val Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr
    370                 375                 380                 
Asp Val Leu Met Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe
385                 390                 395                 400 
Val Val Thr Cys Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile
                405                 410                 415     
Ser Asp Pro Thr Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val
            420                 425                 430         
Asp Val Asp Glu Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly
        435                 440                 445             
Ser Gly Thr Tyr Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu
    450                 455                 460                 
Ala Leu Thr Ser Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser
465                 470                 475                 480 
Pro Leu Arg Met Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala
                485                 490                 495     
Ile Phe Val Thr Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu
            500                 505                 510         
Tyr Asn Pro Ile Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly
        515                 520                 525             
Leu Ser Val Phe Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn
    530                 535                 540                 
Gln Glu Lys Asp Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser
545                 550                 555                 560 


<210> 6605
<211> 1838
<212> PRT
<213> Homo sapiens

<400> 6605
Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly
 1               5                  10                  15      
Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro
            20                  25                  30          
Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe
        35                  40                  45              
His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr
    50                  55                  60                  
Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp
65                  70                  75                  80  
Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe
                85                  90                  95      
Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser
            100                 105                 110         
Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile
        115                 120                 125             
Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr
    130                 135                 140                 
Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu
145                 150                 155                 160 
Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn
                165                 170                 175     
Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp
            180                 185                 190         
Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly
        195                 200                 205             
Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu
    210                 215                 220                 
Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr
225                 230                 235                 240 
Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp
                245                 250                 255     
Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr
            260                 265                 270         
Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys
        275                 280                 285             
Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr
    290                 295                 300                 
Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met
305                 310                 315                 320 
Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly
                325                 330                 335     
Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr
            340                 345                 350         
Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr
        355                 360                 365             
Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser
    370                 375                 380                 
Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu
385                 390                 395                 400 
Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr
                405                 410                 415     
Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro
            420                 425                 430         
Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro
        435                 440                 445             
Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly
    450                 455                 460                 
Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro
465                 470                 475                 480 
Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly
                485                 490                 495     
Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu
            500                 505                 510         
Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly
        515                 520                 525             
Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser
    530                 535                 540                 
Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro
545                 550                 555                 560 
Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro
                565                 570                 575     
Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly
            580                 585                 590         
Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg
        595                 600                 605             
Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr
    610                 615                 620                 
Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly
625                 630                 635                 640 
Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro
                645                 650                 655     
Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg
            660                 665                 670         
Gly Leu Pro Gly Lys Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly
        675                 680                 685             
Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln
    690                 695                 700                 
Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro
705                 710                 715                 720 
Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly
                725                 730                 735     
Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu
            740                 745                 750         
Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu
        755                 760                 765             
Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly
    770                 775                 780                 
Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile
785                 790                 795                 800 
Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro
                805                 810                 815     
Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly
            820                 825                 830         
Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg
        835                 840                 845             
Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys
    850                 855                 860                 
Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly
865                 870                 875                 880 
Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu
                885                 890                 895     
Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg
            900                 905                 910         
Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly
        915                 920                 925             
Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro
    930                 935                 940                 
Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro
945                 950                 955                 960 
Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly
                965                 970                 975     
His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro
            980                 985                 990         
Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr
        995                 1000                1005            
Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly
    1010                1015                1020                
Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys Gly Asp
1025                1030                1035                1040
Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro Gly Leu Arg
                1045                1050                1055    
Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val Gly Ala Leu Gly
            1060                1065                1070        
Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Ser
        1075                1080                1085            
Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala Gly Pro Ile Gly Ile Pro
    1090                1095                1100                
Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly
1105                1110                1115                1120
Ala Pro Gly Glu Lys Gly Pro Gln Gly Pro Ala Gly Arg Asp Gly Leu
                1125                1130                1135    
Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Val Gly Pro Pro
            1140                1145                1150        
Gly Glu Asp Gly Asp Lys Gly Glu Ile Gly Glu Pro Gly Gln Lys Gly
        1155                1160                1165            
Ser Lys Gly Asp Lys Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly Pro
    1170                1175                1180                
Gln Gly Pro Ile Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro
1185                1190                1195                1200
Gly Pro Arg Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly
                1205                1210                1215    
Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu
            1220                1225                1230        
Pro Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met
        1235                1240                1245            
Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro Gly
    1250                1255                1260                
Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro Gly Ala
1265                1270                1275                1280
Val Gly Glu Lys Gly Glu Pro Gly Glu Ala Gly Glu Pro Gly Pro Ser
                1285                1290                1295    
Gly Arg Ser Gly Pro Pro Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly
            1300                1305                1310        
Glu Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro Gly Pro Lys Gly Pro
        1315                1320                1325            
Pro Gly Asp Asp Gly Pro Lys Gly Ser Pro Gly Pro Val Gly Phe Pro
    1330                1335                1340                
Gly Asp Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Gln Asp Gly
1345                1350                1355                1360
Pro Pro Gly Asp Lys Gly Asp Asp Gly Glu Pro Gly Gln Thr Gly Ser
                1365                1370                1375    
Pro Gly Pro Thr Gly Glu Pro Gly Pro Ser Gly Pro Pro Gly Lys Arg
            1380                1385                1390        
Gly Pro Pro Gly Pro Ala Gly Pro Glu Gly Arg Gln Gly Glu Lys Gly
        1395                1400                1405            
Ala Lys Gly Glu Ala Gly Leu Glu Gly Pro Pro Gly Lys Thr Gly Pro
    1410                1415                1420                
Ile Gly Pro Gln Gly Ala Pro Gly Lys Pro Gly Pro Asp Gly Leu Arg
1425                1430                1435                1440
Gly Ile Pro Gly Pro Val Gly Glu Gln Gly Leu Pro Gly Ser Pro Gly
                1445                1450                1455    
Pro Asp Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Leu
            1460                1465                1470        
Lys Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His Pro Gly Leu Ile
        1475                1480                1485            
Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys Gly Asp Arg Gly
    1490                1495                1500                
Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly Glu Gln Gly Ile
1505                1510                1515                1520
Thr Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Pro
                1525                1530                1535    
Gly Pro Pro Gly Pro Lys Gly Ala Lys Gly Ser Ser Gly Pro Thr Gly
            1540                1545                1550        
Pro Arg Gly Glu Ala Gly His Pro Gly Pro Pro Gly Pro Pro Gly Pro
        1555                1560                1565            
Pro Gly Glu Val Ile Gln Pro Leu Pro Ile Gln Ala Ser Arg Thr Arg
    1570                1575                1580                
Arg Asn Ile Asp Ala Ser Gln Leu Leu Asp Asp Gly Asn Gly Glu Asn
1585                1590                1595                1600
Tyr Val Asp Tyr Ala Asp Gly Met Glu Glu Ile Phe Gly Ser Leu Asn
                1605                1610                1615    
Ser Leu Lys Leu Glu Ile Glu Gln Met Lys Arg Pro Leu Gly Thr Gln
            1620                1625                1630        
Gln Asn Pro Ala Arg Thr Cys Lys Asp Leu Gln Leu Cys His Pro Asp
        1635                1640                1645            
Phe Pro Asp Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg
    1650                1655                1660                
Asp Ser Phe Lys Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys
1665                1670                1675                1680
Val Phe Pro Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro
                1685                1690                1695    
Lys Glu Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu
            1700                1705                1710        
Leu Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val Val Gln Met
        1715                1720                1725            
Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn Val Thr Tyr
    1730                1735                1740                
His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr Gly Ser Tyr
1745                1750                1755                1760
Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu Met Ser Tyr
                1765                1770                1775    
Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly Cys Ala Thr Lys
            1780                1785                1790        
Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp Thr Pro Lys Val Glu
        1795                1800                1805            
Gln Val Pro Ile Val Asp Ile Met Phe Asn Asp Phe Gly Glu Ala Ser
    1810                1815                1820                
Gln Lys Phe Gly Phe Glu Val Gly Pro Ala Cys Phe Met Gly
1825                1830                1835            


<210> 6606
<211> 1489
<212> PRT
<213> Homo sapiens

<400> 6606
Gly Asp Ile Gln Gln Leu Leu Phe Val Ser Asp His Arg Ala Ala Tyr
 1               5                  10                  15      
Asp Tyr Cys Glu His Tyr Ser Pro Asp Cys Asp Thr Ala Val Pro Asp
            20                  25                  30          
Thr Pro Gln Ser Gln Asp Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly
        35                  40                  45              
Asp Gly Glu Gly Glu Thr Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp
    50                  55                  60                  
Pro Glu Asp Leu Gly Lys Glu Pro Thr Pro Ser Lys Lys Pro Val Glu
65                  70                  75                  80  
Ala Ala Lys Glu Thr Thr Glu Val Pro Glu Glu Leu Thr Pro Thr Pro
                85                  90                  95      
Thr Glu Ala Ala Pro Met Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu
            100                 105                 110         
Glu Asp Val Gly Ile Gly Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr
        115                 120                 125             
Tyr Thr Pro Ser Pro Tyr Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu
    130                 135                 140                 
Asn Pro Asp Gln Pro Thr Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr
145                 150                 155                 160 
Ser Thr Ala Asp Thr Ser Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly
                165                 170                 175     
Glu Gly Ala Asp Asp Leu Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg
            180                 185                 190         
Asn Leu Asp Glu Asn Tyr Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser
        195                 200                 205             
Pro Ser Glu Ile Gly Pro Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr
    210                 215                 220                 
Glu Gly Ile Gly Gly Pro Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro
225                 230                 235                 240 
Ala Ile Ile Glu Pro Gly Met Leu Ile Glu Gly Pro Pro Gly Pro Glu
                245                 250                 255     
Gly Pro Ala Gly Leu Pro Gly Pro Pro Gly Thr Met Gly Pro Thr Gly
            260                 265                 270         
Gln Val Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu
        275                 280                 285             
Pro Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu
    290                 295                 300                 
Pro Phe Arg Phe Gly Gly Gly Gly Asp Ala Gly Ser Lys Gly Pro Met
305                 310                 315                 320 
Val Ser Ala Gln Glu Ser Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg
                325                 330                 335     
Leu Ala Leu Arg Gly Pro Ala Gly Pro Met Gly Leu Thr Gly Arg Pro
            340                 345                 350         
Gly Pro Val Gly Pro Pro Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly
        355                 360                 365             
Asp Val Gly Pro Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro
    370                 375                 380                 
Ala Gly Lys Pro Gly Arg Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg
385                 390                 395                 400 
Gly Met Pro Gly Gln Thr Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly
                405                 410                 415     
Leu Ala Gly Leu Pro Gly Glu Lys Gly His Arg Gly His Pro Gly Lys
            420                 425                 430         
Glu Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln
        435                 440                 445             
Gly Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Val Arg Glu Thr
    450                 455                 460                 
His Ala Thr Pro Gly Arg Pro Gly Val Cys Cys Gly Gly Trp Ser Ser
465                 470                 475                 480 
His Leu Leu Phe Ser Gly Leu Gln Gly Glu Ile Gly Pro Pro Gly Pro
                485                 490                 495     
Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Gly Gly Pro Asn
            500                 505                 510         
Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys Gly Lys Leu Gly
        515                 520                 525             
Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly Ser
    530                 535                 540                 
Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu Lys Gly Gly Arg
545                 550                 555                 560 
Val Arg Ile Ala Trp Pro Leu Gly Arg Gln Leu Val Arg Leu Pro Arg
                565                 570                 575     
Cys Leu Ala Ser Cys Phe Ser Pro Leu Ser Phe Pro Leu Lys Gly Asn
            580                 585                 590         
Ser Gly Gly Asp Gly Pro Ala Gly Pro Pro Gly Glu Arg Gly Pro Asn
        595                 600                 605             
Gly Pro Gln Gly Pro Thr Gly Phe Pro Gly Pro Lys Gly Pro Pro Val
    610                 615                 620                 
Ser Asn Gly Phe Leu Ala Gly Pro Ala Leu Pro Val Pro Ser Lys Thr
625                 630                 635                 640 
His Leu Ser Pro Pro Pro Pro Val Phe Ser Glu Gly Pro Thr Gly Glu
                645                 650                 655     
Thr Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro
            660                 665                 670         
Gly Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys Gly
        675                 680                 685             
Asp Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro Gly Leu
    690                 695                 700                 
Arg Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val Gly Ala Leu
705                 710                 715                 720 
Gly Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly
                725                 730                 735     
Ser Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala Gly Pro Ile Gly Ile
            740                 745                 750         
Pro Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Pro Ala Gly Glu Lys
        755                 760                 765             
Gly Ala Pro Gly Glu Lys Gly Pro Gln Gly Pro Ala Gly Arg Asp Gly
    770                 775                 780                 
Leu Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Val Gly Pro
785                 790                 795                 800 
Pro Gly Glu Asp Gly Asp Lys Val Arg Gln Ile Gln Ser Asp Pro Trp
                805                 810                 815     
Leu Gly Leu Ala Gly Gln Thr Gly Gly Pro Pro Gly Pro Thr Gly Pro
            820                 825                 830         
Gln Gly Pro Ile Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro
        835                 840                 845             
Gly Pro Arg Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly
    850                 855                 860                 
Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu
865                 870                 875                 880 
Pro Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met
                885                 890                 895     
Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro Gly
            900                 905                 910         
Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro Gly Ala
        915                 920                 925             
Val Gly Glu Lys Lys Thr Gly Glu Ala His Leu Ala Leu Gly Gly Asp
    930                 935                 940                 
Val Val Gly Ser Glu Asp Leu Thr Leu Ala Ser Phe Leu Gln Gly Pro
945                 950                 955                 960 
Lys Gly Glu Arg Gly Glu Lys Gly Glu Ser Gly Pro Ser Gly Ala Ala
                965                 970                 975     
Gly Pro Pro Gly Pro Lys Gly Pro Pro Gly Asp Asp Gly Pro Lys Gly
            980                 985                 990         
Ser Pro Val Ser Ile Pro Asp Thr Pro Gln Gly Pro Cys Ser Arg Gly
        995                 1000                1005            
Gly Ala Leu His Trp Asp His Ser Asp Ser Leu Ala Val His Ser Ala
    1010                1015                1020                
Leu Arg Thr Ala Ser Arg Pro Phe His Val Leu Gly Phe Pro Ser Ser
1025                1030                1035                1040
Gly Pro Gly Pro Gly Cys Leu Glu Pro Arg Ala Pro Asp Leu Ile Leu
                1045                1050                1055    
Pro Ser Ala Val Leu Gln Gly Glu Ala Gly Leu Glu Gly Pro Pro Gly
            1060                1065                1070        
Lys Thr Gly Pro Ile Gly Pro Gln Gly Ala Pro Gly Lys Pro Gly Pro
        1075                1080                1085            
Asp Gly Leu Arg Gly Ile Pro Gly Pro Val Gly Glu Gln Gly Leu Pro
    1090                1095                1100                
Gly Ser Pro Gly Pro Asp Gly Pro Pro Gly Pro Met Gly Pro Pro Gly
1105                1110                1115                1120
Leu Pro Gly Leu Lys Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His
                1125                1130                1135    
Pro Gly Leu Ile Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys
            1140                1145                1150        
Gly Asp Arg Gly Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly
        1155                1160                1165            
Glu Gln Ala Asp Arg Cys Pro Cys Ser Pro Gly Cys Gln Ala Pro Gly
    1170                1175                1180                
Asn Pro Cys Arg Cys Gly Pro Ser Cys Pro Cys Ser Ala His Ile Leu
1185                1190                1195                1200
Gly Pro Phe Pro Ser Ser Ile Thr His Arg Cys Ser Cys Ser Val Pro
                1205                1210                1215    
Gln Gly Pro Pro Gly Glu Val Ile Gln Pro Leu Pro Ile Gln Ala Ser
            1220                1225                1230        
Arg Thr Arg Arg Asn Ile Asp Ala Ser Gln Leu Leu Asp Asp Gly Asn
        1235                1240                1245            
Gly Glu Asn Tyr Val Asp Tyr Ala Asp Gly Met Glu Glu Ile Phe Gly
    1250                1255                1260                
Ser Leu Asn Ser Leu Lys Leu Glu Ile Glu Gln Met Lys Arg Pro Leu
1265                1270                1275                1280
Gly Thr Gln Gln Asn Pro Ala Arg Thr Cys Lys Asp Leu Gln Leu Cys
                1285                1290                1295    
His Pro Asp Phe Pro Asp Gly Glu Tyr Trp Val Asp Pro Asn Gln Gly
            1300                1305                1310        
Cys Ser Arg Asp Ser Phe Lys Val Tyr Cys Asn Phe Thr Ala Gly Gly
        1315                1320                1325            
Ser Thr Cys Val Phe Pro Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr
    1330                1335                1340                
Ser Trp Pro Lys Glu Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg
1345                1350                1355                1360
Gly Lys Leu Leu Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val
                1365                1370                1375    
Val Gln Met Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn
            1380                1385                1390        
Val Thr Tyr His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr
        1395                1400                1405            
Gly Ser Tyr Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu
    1410                1415                1420                
Met Ser Tyr Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly Cys
1425                1430                1435                1440
Ala Thr Lys Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp Thr Pro
                1445                1450                1455    
Lys Val Glu Gln Val Pro Ile Val Asp Ile Met Phe Asn Asp Phe Gly
            1460                1465                1470        
Glu Ala Ser Gln Lys Phe Gly Phe Glu Val Gly Pro Ala Cys Phe Met
        1475                1480                1485            
Gly
    


<210> 6607
<211> 822
<212> PRT
<213> Homo sapiens

<400> 6607
Met Lys Pro Ala Leu Leu Pro Trp Ala Leu Leu Leu Leu Ala Thr Ala
 1               5                  10                  15      
Leu Gly Pro Gly Pro Gly Pro Thr Ala Asp Ala Gln Glu Ser Cys Ser
            20                  25                  30          
Met Arg Cys Gly Ala Leu Asp Gly Pro Cys Ser Cys His Pro Thr Cys
        35                  40                  45              
Ser Gly Leu Gly Thr Cys Cys Leu Asp Phe Arg Asp Phe Cys Leu Glu
    50                  55                  60                  
Ile Leu Pro Tyr Ser Gly Ser Met Met Gly Gly Lys Asp Phe Val Val
65                  70                  75                  80  
Arg His Phe Lys Met Ser Ser Pro Thr Asp Ala Ser Val Ile Cys Arg
                85                  90                  95      
Phe Lys Asp Ser Ile Gln Thr Leu Gly His Val Asp Ser Ser Gly Gln
            100                 105                 110         
Val His Cys Val Ser Pro Leu Leu Tyr Glu Ser Gly Arg Ile Pro Phe
        115                 120                 125             
Thr Val Ser Leu Asp Asn Gly His Ser Phe Pro Arg Ala Gly Thr Trp
    130                 135                 140                 
Leu Ala Val His Pro Asn Lys Val Ser Met Met Glu Lys Ser Glu Leu
145                 150                 155                 160 
Val Asn Glu Thr Arg Trp Gln Tyr Tyr Gly Thr Ala Asn Thr Ser Gly
                165                 170                 175     
Asn Leu Ser Leu Thr Trp His Val Lys Ser Leu Pro Thr Gln Thr Ile
            180                 185                 190         
Thr Ile Glu Leu Trp Gly Tyr Glu Glu Thr Gly Met Pro Tyr Ser Gln
        195                 200                 205             
Glu Trp Thr Ala Lys Trp Ser Tyr Leu Tyr Pro Leu Ala Thr His Ile
    210                 215                 220                 
Pro Asn Ser Gly Ser Phe Thr Phe Thr Pro Lys Pro Ala Pro Pro Ser
225                 230                 235                 240 
Tyr Gln Arg Trp Arg Val Gly Ala Leu Arg Ile Ile Asp Ser Lys Asn
                245                 250                 255     
Tyr Ala Gly Gln Lys Asp Val Gln Ala Leu Trp Thr Asn Asp His Ala
            260                 265                 270         
Leu Ala Trp His Leu Ser Asp Asp Phe Arg Glu Asp Pro Val Ala Trp
        275                 280                 285             
Ala Arg Thr Gln Cys Gln Ala Trp Glu Glu Leu Glu Asp Gln Leu Pro
    290                 295                 300                 
Asn Phe Leu Glu Glu Leu Pro Asp Cys Pro Cys Thr Leu Thr Gln Ala
305                 310                 315                 320 
Arg Ala Asp Ser Gly Arg Phe Phe Thr Asp Tyr Gly Cys Asp Met Glu
                325                 330                 335     
Gln Gly Ser Val Cys Thr Tyr His Pro Gly Ala Val His Cys Val Arg
            340                 345                 350         
Ser Val Gln Ala Ser Leu Arg Tyr Gly Ser Gly Gln Gln Cys Cys Tyr
        355                 360                 365             
Thr Ala Asp Gly Thr Gln Leu Leu Thr Ala Asp Ser Ser Gly Gly Ser
    370                 375                 380                 
Thr Pro Asp Arg Gly His Asp Trp Gly Ala Pro Pro Phe Arg Thr Pro
385                 390                 395                 400 
Pro Arg Val Pro Ser Met Ser His Trp Leu Tyr Asp Val Leu Ser Phe
                405                 410                 415     
Tyr Tyr Cys Cys Leu Trp Ala Pro Asp Cys Pro Arg Tyr Met Gln Arg
            420                 425                 430         
Arg Pro Ser Asn Asp Cys Arg Asn Tyr Arg Pro Pro Arg Leu Ala Ser
        435                 440                 445             
Ala Phe Gly Asp Pro His Phe Val Thr Phe Asp Gly Thr Asn Phe Thr
    450                 455                 460                 
Phe Asn Gly Arg Gly Glu Tyr Val Leu Leu Glu Ala Ala Leu Thr Asp
465                 470                 475                 480 
Leu Arg Val Gln Ala Arg Ala Gln Pro Gly Thr Met Ser Asn Gly Thr
                485                 490                 495     
Glu Thr Arg Gly Thr Gly Leu Thr Ala Val Ala Val Gln Glu Gly Asn
            500                 505                 510         
Ser Asp Val Val Glu Val Arg Leu Ala Asn Arg Thr Gly Gly Leu Glu
        515                 520                 525             
Val Leu Leu Asn Gln Glu Val Leu Ser Phe Thr Glu Gln Ser Trp Met
    530                 535                 540                 
Asp Leu Lys Gly Met Phe Leu Ser Val Ala Ala Gly Asp Arg Val Ser
545                 550                 555                 560 
Ile Met Leu Ala Ser Gly Ala Gly Leu Glu Val Ser Val Gln Gly Pro
                565                 570                 575     
Phe Leu Ser Val Ser Val Leu Leu Pro Glu Lys Phe Leu Thr His Thr
            580                 585                 590         
His Gly Leu Leu Gly Thr Leu Asn Asn Asp Pro Thr Asp Asp Phe Thr
        595                 600                 605             
Leu His Ser Gly Arg Val Leu Pro Pro Gly Thr Ser Pro Gln Glu Leu
    610                 615                 620                 
Phe Leu Phe Gly Ala Asn Trp Thr Val His Asn Ala Ser Ser Leu Leu
625                 630                 635                 640 
Thr Tyr Asp Ser Trp Phe Leu Val His Asn Phe Leu Tyr Gln Pro Lys
                645                 650                 655     
His Asp Pro Thr Phe Glu Pro Leu Phe Pro Ser Glu Thr Thr Leu Asn
            660                 665                 670         
Pro Ser Leu Ala Gln Glu Ala Ala Lys Leu Cys Gly Asp Asp His Phe
        675                 680                 685             
Cys Asn Phe Asp Val Ala Ala Thr Gly Ser Leu Ser Thr Gly Thr Ala
    690                 695                 700                 
Thr Arg Val Ala His Gln Leu His Gln Arg Arg Met Gln Ser Leu Gln
705                 710                 715                 720 
Pro Val Val Ser Cys Gly Trp Leu Ala Pro Pro Pro Asn Gly Gln Lys
                725                 730                 735     
Glu Gly Asn Arg Tyr Leu Ala Gly Ser Thr Ile Tyr Phe His Cys Asp
            740                 745                 750         
Asn Gly Tyr Ser Leu Ala Gly Ala Glu Thr Ser Thr Cys Gln Ala Asp
        755                 760                 765             
Gly Thr Trp Ser Ser Pro Thr Pro Lys Cys Gln Pro Gly Arg Ser Tyr
    770                 775                 780                 
Ala Val Leu Leu Gly Ile Ile Phe Gly Gly Leu Ala Val Val Ala Ala
785                 790                 795                 800 
Val Ala Leu Val Tyr Val Leu Leu Arg Arg Arg Lys Gly Asn Thr His
                805                 810                 815     
Val Trp Gly Ala Gln Pro
            820         


<210> 6608
<211> 471
<212> PRT
<213> Homo sapiens

<400> 6608
Met Ala Arg Glu Met Thr Ile Leu Gly Ser Ala Val Leu Thr Leu Leu
 1               5                  10                  15      
Leu Ala Gly Tyr Leu Ala Gln Gln Tyr Leu Pro Leu Pro Thr Pro Lys
            20                  25                  30          
Val Ile Gly Ile Asp Leu Gly Thr Thr Tyr Cys Ser Val Gly Val Phe
        35                  40                  45              
Phe Pro Gly Thr Gly Lys Val Lys Val Ile Pro Asp Glu Asn Gly His
    50                  55                  60                  
Ile Ser Ile Pro Ser Met Val Ser Phe Thr Asp Asn Asp Val Tyr Val
65                  70                  75                  80  
Gly Tyr Glu Ser Val Glu Leu Ala Asp Ser Asn Pro Gln Asn Thr Ile
                85                  90                  95      
Tyr Asp Ala Lys Arg Phe Ile Gly Lys Ile Phe Thr Ala Glu Glu Leu
            100                 105                 110         
Glu Ala Glu Ile Gly Arg Tyr Pro Phe Lys Val Leu Asn Lys Asn Gly
        115                 120                 125             
Met Val Glu Phe Ser Val Thr Ser Asn Glu Thr Ile Thr Val Ser Pro
    130                 135                 140                 
Glu Tyr Val Gly Ser Arg Leu Leu Leu Lys Leu Lys Glu Met Ala Glu
145                 150                 155                 160 
Ala Tyr Leu Gly Met Pro Val Ala Asn Ala Val Ile Ser Val Pro Ala
                165                 170                 175     
Glu Phe Asp Leu Lys Gln Arg Asn Ser Thr Ile Glu Ala Ala Asn Leu
            180                 185                 190         
Ala Gly Leu Lys Ile Leu Arg Val Ile Asn Glu Pro Thr Ala Ala Ala
        195                 200                 205             
Met Ala Tyr Gly Leu His Lys Ala Asp Val Phe His Val Leu Val Ile
    210                 215                 220                 
Asp Leu Gly Gly Gly Thr Leu Asp Val Ser Leu Leu Asn Lys Gln Gly
225                 230                 235                 240 
Gly Met Phe Leu Thr Arg Ala Met Ser Gly Asn Asn Lys Leu Gly Gly
                245                 250                 255     
Gln Asp Phe Asn Gln Arg Leu Leu Gln Tyr Leu Tyr Lys Gln Ile Tyr
            260                 265                 270         
Gln Thr Tyr Gly Phe Val Pro Ser Arg Lys Glu Glu Ile His Arg Leu
        275                 280                 285             
Arg Gln Ala Val Glu Met Val Lys Leu Asn Leu Thr Leu His Gln Ser
    290                 295                 300                 
Ala Gln Leu Ser Val Leu Leu Thr Val Glu Glu Gln Asp Arg Lys Glu
305                 310                 315                 320 
Pro His Ser Ser Asp Thr Glu Leu Pro Lys Asp Lys Leu Ser Ser Ala
                325                 330                 335     
Asp Asp His Arg Val Asn Ser Gly Phe Gly Arg Gly Leu Ser Asp Lys
            340                 345                 350         
Lys Ser Gly Glu Ser Gln Val Leu Phe Glu Thr Glu Ile Ser Arg Lys
        355                 360                 365             
Leu Phe Asp Thr Leu Asn Glu Asp Leu Phe Gln Lys Ile Leu Val Pro
    370                 375                 380                 
Ile Gln Gln Val Leu Lys Glu Gly His Leu Glu Lys Thr Glu Ile Asp
385                 390                 395                 400 
Glu Val Val Leu Val Gly Gly Ser Thr Arg Ile Pro Arg Ile Arg Gln
                405                 410                 415     
Val Ile Gln Glu Phe Phe Gly Lys Asp Pro Asn Thr Ser Val Asp Pro
            420                 425                 430         
Asp Leu Ala Val Val Thr Gly Val Ala Ile Gln Ala Gly Ile Asp Gly
        435                 440                 445             
Gly Ser Trp Pro Leu Gln Val Ser Ala Leu Glu Ile Pro Asn Lys His
    450                 455                 460                 
Leu Gln Lys Thr Asn Phe Asn
465                 470     


<210> 6609
<211> 6620
<212> PRT
<213> Homo sapiens

<400> 6609
Met Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro
 1               5                  10                  15      
Lys Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Cys Gln
            20                  25                  30          
Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln
        35                  40                  45              
Pro Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu
    50                  55                  60                  
Tyr Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr
65                  70                  75                  80  
Val Cys Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Ala Val Gly
                85                  90                  95      
Leu Gln Val Asp Ala Glu Ala Ala Cys Ala Glu Gln Ala Pro His Phe
            100                 105                 110         
Leu Leu Arg Pro Thr Ser Ile Arg Val Arg Glu Gly Ser Glu Ala Thr
        115                 120                 125             
Phe Arg Cys Arg Val Gly Gly Ser Pro Arg Pro Ala Val Ser Trp Ser
    130                 135                 140                 
Lys Asp Gly Arg Arg Leu Gly Glu Pro Asp Gly Pro Arg Val Arg Val
145                 150                 155                 160 
Glu Glu Leu Gly Glu Ala Ser Ala Leu Arg Ile Arg Ala Ala Arg Pro
                165                 170                 175     
Arg Asp Gly Gly Thr Tyr Glu Val Arg Ala Glu Asn Pro Leu Gly Ala
            180                 185                 190         
Ala Ser Ala Ala Ala Ala Leu Val Val Asp Ser Asp Ala Ala Asp Thr
        195                 200                 205             
Ala Ser Arg Pro Gly Thr Ser Thr Ala Ala Leu Leu Ala His Leu Gln
    210                 215                 220                 
Arg Arg Arg Glu Ala Met Arg Ala Glu Gly Ala Pro Ala Ser Pro Pro
225                 230                 235                 240 
Ser Thr Gly Thr Arg Thr Cys Thr Val Thr Glu Gly Lys His Ala Arg
                245                 250                 255     
Leu Ser Cys Tyr Val Thr Gly Glu Pro Lys Pro Glu Thr Val Trp Lys
            260                 265                 270         
Lys Asp Gly Gln Leu Val Thr Glu Gly Arg Arg His Val Val Tyr Glu
        275                 280                 285             
Asp Ala Gln Glu Asn Phe Val Leu Lys Ile Leu Phe Cys Lys Gln Ser
    290                 295                 300                 
Asp Arg Gly Leu Tyr Thr Cys Thr Ala Ser Asn Leu Val Gly Gln Thr
305                 310                 315                 320 
Tyr Ser Ser Val Leu Val Val Val Arg Glu Pro Ala Val Pro Phe Lys
                325                 330                 335     
Lys Arg Leu Gln Asp Leu Glu Val Arg Glu Lys Glu Ser Ala Thr Phe
            340                 345                 350         
Leu Cys Glu Val Pro Gln Pro Ser Thr Glu Ala Ala Trp Phe Lys Glu
        355                 360                 365             
Glu Thr Arg Leu Trp Ala Ser Ala Lys Tyr Gly Ile Glu Glu Glu Gly
    370                 375                 380                 
Thr Glu Arg Arg Leu Thr Val Arg Asn Val Ser Ala Asp Asp Asp Ala
385                 390                 395                 400 
Val Tyr Ile Cys Glu Thr Pro Glu Gly Ser Arg Thr Val Ala Glu Leu
                405                 410                 415     
Ala Val Gln Gly Asn Leu Leu Arg Lys Leu Pro Arg Lys Thr Ala Val
            420                 425                 430         
Arg Val Gly Asp Thr Ala Met Phe Cys Val Glu Leu Ala Val Pro Val
        435                 440                 445             
Gly Pro Val His Trp Leu Arg Asn Gln Glu Glu Val Val Ala Gly Gly
    450                 455                 460                 
Arg Val Ala Ile Ser Ala Glu Gly Thr Arg His Thr Leu Thr Ile Ser
465                 470                 475                 480 
Gln Cys Cys Leu Glu Asp Val Gly Gln Val Ala Phe Met Ala Gly Asp
                485                 490                 495     
Cys Gln Thr Ser Thr Arg Phe Cys Val Ser Ala Pro Arg Lys Pro Pro
            500                 505                 510         
Leu Gln Pro Pro Val Asp Pro Val Val Lys Ala Arg Met Glu Ser Ser
        515                 520                 525             
Val Ile Leu Ser Trp Ser Pro Pro Pro His Gly Glu Arg Pro Val Thr
    530                 535                 540                 
Ile Asp Gly Tyr Leu Val Glu Lys Lys Lys Leu Gly Thr Tyr Thr Trp
545                 550                 555                 560 
Ile Arg Cys His Glu Ala Glu Trp Val Ala Thr Pro Glu Leu Thr Val
                565                 570                 575     
Ala Asp Val Ala Glu Glu Gly Asn Phe Gln Phe Arg Val Ser Ala Leu
            580                 585                 590         
Asn Ser Phe Gly Gln Ser Pro Tyr Leu Glu Phe Pro Gly Thr Val His
        595                 600                 605             
Leu Ala Pro Lys Leu Ala Val Arg Thr Pro Leu Lys Ala Val Gln Ala
    610                 615                 620                 
Val Glu Gly Gly Glu Val Thr Phe Ser Val Asp Leu Thr Val Ala Ser
625                 630                 635                 640 
Ala Gly Glu Trp Phe Leu Asp Gly Gln Ala Leu Lys Ala Ser Ser Val
                645                 650                 655     
Tyr Glu Ile His Cys Asp Arg Thr Arg His Thr Leu Thr Ile Arg Glu
            660                 665                 670         
Val Pro Ala Ser Leu His Gly Ala Gln Leu Lys Phe Val Ala Asn Gly
        675                 680                 685             
Ile Glu Ser Ser Ile Arg Met Glu Val Arg Ala Ala Pro Gly Leu Thr
    690                 695                 700                 
Ala Asn Lys Pro Pro Ala Ala Ala Ala Arg Glu Val Leu Ala Arg Leu
705                 710                 715                 720 
His Glu Glu Ala Gln Leu Leu Ala Glu Leu Ser Asp Gln Ala Ala Ala
                725                 730                 735     
Val Thr Trp Leu Lys Asp Gly Arg Thr Leu Ser Pro Gly Pro Lys Tyr
            740                 745                 750         
Glu Val Gln Ala Ser Ala Gly Arg Arg Val Leu Leu Val Arg Asp Val
        755                 760                 765             
Ala Arg Asp Asp Ala Gly Leu Tyr Glu Cys Val Ser Arg Gly Gly Arg
    770                 775                 780                 
Ile Ala Tyr Gln Leu Ser Val Gln Gly Leu Ala Arg Phe Leu His Lys
785                 790                 795                 800 
Asp Met Ala Gly Ser Cys Val Asp Ala Val Ala Gly Gly Pro Ala Gln
                805                 810                 815     
Phe Glu Cys Glu Thr Ser Glu Ala His Val His Val His Trp Tyr Lys
            820                 825                 830         
Asp Gly Met Glu Leu Gly His Ser Gly Glu Arg Phe Leu Gln Glu Asp
        835                 840                 845             
Val Gly Thr Arg His Arg Leu Val Ala Ala Thr Val Thr Arg Gln Asp
    850                 855                 860                 
Glu Gly Thr Tyr Ser Cys Arg Val Gly Glu Asp Ser Val Asp Phe Arg
865                 870                 875                 880 
Leu Arg Val Ser Glu Pro Lys Val Val Phe Ala Lys Glu Gln Leu Ala
                885                 890                 895     
Arg Arg Lys Leu Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys
            900                 905                 910         
Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys
        915                 920                 925             
Lys Leu Ser Ser Ser Ser Lys Val Cys Met Glu Ala Thr Gly Cys Thr
    930                 935                 940                 
Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr
945                 950                 955                 960 
Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu Asp Val Lys
                965                 970                 975     
Glu Pro Lys Val Val Phe Ala Lys Asp Gln Val Ala His Ser Glu Val
            980                 985                 990         
Gln Ala Glu Ala Gly Ala Asn Ala Thr Leu Ser Cys Glu Val Ala Gln
        995                 1000                1005            
Ala Gln Ala Glu Val Met Trp Tyr Lys Asp Gly Lys Lys Leu Ser Ser
    1010                1015                1020                
Ser Leu Lys Val His Val Glu Ala Lys Gly Cys Arg Arg Arg Leu Val
1025                1030                1035                1040
Val Gln Gln Ala Gly Lys Thr Asp Ala Gly Asp Tyr Ser Cys Glu Ala
                1045                1050                1055    
Arg Gly Gln Arg Val Ser Phe Arg Leu His Ile Thr Glu Pro Lys Met
            1060                1065                1070        
Met Phe Ala Lys Glu Gln Ser Val His Asn Glu Val Gln Ala Glu Ala
        1075                1080                1085            
Gly Ala Ser Ala Met Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu
    1090                1095                1100                
Val Thr Trp Tyr Lys Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Val
1105                1110                1115                1120
Gly Met Glu Val Lys Gly Cys Thr Arg Arg Leu Val Leu Pro Gln Ala
                1125                1130                1135    
Gly Lys Ala Asp Ala Gly Glu Tyr Ser Cys Glu Ala Gly Gly Gln Arg
            1140                1145                1150        
Val Ser Phe His Leu His Ile Thr Glu Pro Lys Gly Val Phe Ala Lys
        1155                1160                1165            
Glu Gln Ser Val His Asn Glu Val Gln Ala Glu Ala Gly Thr Thr Ala
    1170                1175                1180                
Met Leu Ser Cys Glu Val Ala Gln Pro Gln Thr Glu Val Thr Trp Tyr
1185                1190                1195                1200
Lys Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Val Arg Met Glu Val
                1205                1210                1215    
Lys Gly Cys Thr Arg Arg Leu Val Val Gln Gln Val Gly Lys Ala Asp
            1220                1225                1230        
Ala Gly Glu Tyr Ser Cys Glu Ala Gly Gly Gln Arg Val Ser Phe Gln
        1235                1240                1245            
Leu His Ile Thr Glu Pro Lys Ala Val Phe Ala Lys Glu Gln Leu Val
    1250                1255                1260                
His Asn Glu Val Arg Thr Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys
1265                1270                1275                1280
Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys
                1285                1290                1295    
Lys Leu Ser Ser Ser Ser Lys Val Arg Ile Glu Ala Ala Gly Cys Met
            1300                1305                1310        
Arg Gln Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr
        1315                1320                1325            
Thr Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu Asp Val Ser
    1330                1335                1340                
Glu Pro Lys Ala Val Phe Ala Lys Glu Gln Leu Ala His Arg Lys Val
1345                1350                1355                1360
Gln Ala Glu Ala Gly Ala Ile Ala Thr Leu Ser Cys Glu Val Ala Gln
                1365                1370                1375    
Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys Lys Leu Ser Ser
            1380                1385                1390        
Ser Ser Lys Val Arg Met Glu Ala Val Gly Cys Thr Arg Arg Leu Val
        1395                1400                1405            
Val Gln Gln Ala Cys Gln Ala Asp Thr Gly Glu Tyr Ser Cys Glu Ala
    1410                1415                1420                
Gly Gly Gln Arg Leu Ser Phe Ser Leu Asp Val Ala Glu Pro Lys Val
1425                1430                1435                1440
Val Phe Ala Lys Glu Gln Pro Val His Arg Glu Val Gln Ala Gln Ala
                1445                1450                1455    
Gly Ala Ser Thr Thr Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu
            1460                1465                1470        
Val Met Trp Tyr Lys Asp Gly Lys Lys Leu Ser Phe Ser Ser Lys Val
        1475                1480                1485            
Arg Met Glu Ala Val Gly Cys Thr Arg Arg Leu Val Val Gln Gln Ala
    1490                1495                1500                
Gly Gln Ala Asp Ala Gly Glu Tyr Ser Cys Glu Ala Gly Ser Gln Arg
1505                1510                1515                1520
Leu Ser Phe His Leu His Val Ala Glu Pro Lys Ala Val Phe Ala Lys
                1525                1530                1535    
Glu Gln Pro Ala Ser Arg Glu Val Gln Ala Glu Ala Gly Thr Ser Ala
            1540                1545                1550        
Thr Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr
        1555                1560                1565            
Lys Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Val Arg Met Glu Ala
    1570                1575                1580                
Val Gly Cys Thr Arg Arg Leu Val Val Gln Glu Ala Gly Gln Ala Asp
1585                1590                1595                1600
Ala Gly Glu Tyr Ser Cys Lys Ala Gly Asp Gln Arg Leu Ser Phe His
                1605                1610                1615    
Leu His Val Ala Glu Pro Lys Val Val Phe Ala Lys Glu Gln Pro Ala
            1620                1625                1630        
His Arg Glu Val Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys
        1635                1640                1645            
Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys
    1650                1655                1660                
Lys Leu Ser Ser Ser Ser Lys Val Arg Val Glu Ala Val Gly Cys Thr
1665                1670                1675                1680
Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr
                1685                1690                1695    
Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe Arg Leu His Val Ala
            1700                1705                1710        
Glu Leu Glu Pro Gln Ile Ser Glu Arg Pro Cys Arg Arg Glu Pro Leu
        1715                1720                1725            
Val Val Lys Glu His Glu Asp Ile Ile Leu Thr Ala Thr Leu Ala Thr
    1730                1735                1740                
Pro Ser Ala Ala Thr Val Thr Trp Leu Lys Asp Gly Val Glu Ile Arg
1745                1750                1755                1760
Arg Ser Lys Arg His Glu Thr Ala Ser Gln Gly Asp Thr His Thr Leu
                1765                1770                1775    
Thr Val His Gly Ala Gln Val Leu Asp Ser Ala Ile Tyr Ser Cys Arg
            1780                1785                1790        
Val Gly Ala Glu Gly Gln Asp Phe Pro Val Gln Val Glu Glu Val Ala
        1795                1800                1805            
Ala Lys Phe Cys Arg Leu Leu Glu Pro Val Cys Gly Glu Leu Gly Gly
    1810                1815                1820                
Thr Val Thr Leu Ala Cys Glu Leu Ser Pro Ala Cys Ala Glu Val Val
1825                1830                1835                1840
Trp Arg Cys Gly Asn Thr Gln Pro Arg Val Gly Lys Arg Phe Gln Met
                1845                1850                1855    
Val Ala Glu Gly Pro Val Arg Ser Leu Thr Val Leu Gly Leu Arg Ala
            1860                1865                1870        
Glu Asp Ala Gly Glu Tyr Val Cys Glu Ser Arg Asp Asp His Thr Ser
        1875                1880                1885            
Ala Gln Leu Thr Val Ser Val Pro Arg Val Val Lys Phe Met Ser Gly
    1890                1895                1900                
Leu Ser Thr Val Val Ala Glu Glu Gly Gly Glu Ala Thr Phe Gln Cys
1905                1910                1915                1920
Val Val Ser Pro Ser Asp Val Ala Val Val Trp Phe Arg Asp Gly Ala
                1925                1930                1935    
Leu Leu Gln Pro Ser Glu Lys Phe Ala Ile Ser Gln Ser Gly Ala Ser
            1940                1945                1950        
His Ser Leu Thr Ile Ser Asp Leu Val Leu Glu Asp Ala Gly Gln Ile
        1955                1960                1965            
Thr Val Glu Ala Glu Gly Ala Ser Ser Ser Ala Ala Leu Arg Val Arg
    1970                1975                1980                
Glu Ala Pro Val Leu Phe Lys Lys Lys Leu Glu Pro Gln Thr Val Glu
1985                1990                1995                2000
Glu Arg Ser Ser Val Thr Leu Glu Val Glu Leu Thr Arg Pro Trp Pro
                2005                2010                2015    
Glu Leu Arg Trp Thr Arg Asn Ala Thr Ala Leu Ala Pro Gly Lys Asn
            2020                2025                2030        
Val Glu Ile His Ala Glu Gly Ala Arg His Arg Leu Val Leu His Asn
        2035                2040                2045            
Val Gly Phe Ala Asp Arg Gly Phe Phe Gly Cys Glu Thr Pro Asp Asp
    2050                2055                2060                
Lys Thr Gln Ala Lys Leu Thr Val Glu Met Arg Gln Val Arg Leu Val
2065                2070                2075                2080
Arg Gly Leu Gln Ala Val Glu Ala Arg Glu Gln Gly Thr Ala Thr Met
                2085                2090                2095    
Glu Val Gln Leu Ser His Ala Asp Val Asp Gly Ser Trp Thr Arg Asp
            2100                2105                2110        
Gly Leu Arg Phe Gln Gln Gly Pro Thr Cys His Leu Ala Val Arg Gly
        2115                2120                2125            
Pro Met His Thr Leu Thr Leu Ser Gly Leu Arg Pro Glu Asp Ser Gly
    2130                2135                2140                
Leu Met Val Phe Lys Ala Glu Gly Val His Thr Ser Ala Arg Leu Val
2145                2150                2155                2160
Val Thr Glu Leu Pro Val Ser Phe Ser Arg Pro Leu Gln Asp Val Val
                2165                2170                2175    
Thr Thr Glu Lys Glu Lys Val Thr Leu Glu Cys Glu Leu Ser Arg Pro
            2180                2185                2190        
Asn Val Asp Val Arg Trp Leu Lys Asp Gly Val Glu Leu Arg Ala Gly
        2195                2200                2205            
Lys Thr Met Ala Ile Ala Ala Gln Gly Ala Cys Arg Ser Leu Thr Ile
    2210                2215                2220                
Tyr Arg Cys Glu Phe Ala Asp Gln Gly Val Tyr Val Cys Asp Ala His
2225                2230                2235                2240
Asp Ala Gln Ser Ser Ala Ser Val Lys Val Gln Gly Arg Thr Tyr Thr
                2245                2250                2255    
Leu Ile Tyr Arg Arg Val Leu Ala Glu Asp Ala Gly Glu Ile Gln Phe
            2260                2265                2270        
Val Ala Glu Asn Ala Glu Ser Arg Ala Gln Leu Arg Val Lys Glu Leu
        2275                2280                2285            
Pro Val Thr Leu Val Arg Pro Leu Arg Asp Lys Ile Ala Met Glu Lys
    2290                2295                2300                
His Arg Gly Val Leu Glu Cys Gln Val Ser Arg Ala Ser Ala Gln Val
2305                2310                2315                2320
Arg Trp Phe Lys Gly Ser Gln Glu Leu Gln Pro Gly Pro Lys Tyr Glu
                2325                2330                2335    
Leu Val Ser Asp Gly Leu Tyr Arg Lys Leu Ile Ile Ser Asp Val His
            2340                2345                2350        
Ala Glu Asp Glu Asp Thr Tyr Thr Cys Asp Ala Gly Asp Val Lys Thr
        2355                2360                2365            
Ser Ala Gln Phe Phe Val Glu Glu Gln Ser Ile Thr Ile Val Arg Gly
    2370                2375                2380                
Leu Gln Asp Val Thr Val Met Glu Pro Ala Pro Ala Trp Phe Glu Cys
2385                2390                2395                2400
Glu Thr Ser Ile Pro Ser Val Arg Pro Pro Lys Trp Leu Leu Gly Lys
                2405                2410                2415    
Thr Val Leu Gln Ala Gly Gly Asn Val Gly Leu Glu Gln Glu Gly Thr
            2420                2425                2430        
Val His Arg Leu Met Leu Arg Arg Thr Cys Ser Thr Met Thr Gly Pro
        2435                2440                2445            
Val His Phe Thr Val Gly Lys Ser Arg Ser Ser Ala Arg Leu Val Val
    2450                2455                2460                
Ser Asp Ile Pro Val Val Leu Thr Arg Pro Leu Glu Pro Lys Thr Gly
2465                2470                2475                2480
Arg Glu Leu Gln Ser Val Val Leu Ser Cys Asp Phe Arg Pro Ala Pro
                2485                2490                2495    
Lys Ala Val Gln Trp Tyr Lys Asp Asp Thr Pro Leu Ser Pro Ser Glu
            2500                2505                2510        
Lys Phe Lys Met Ser Leu Glu Gly Gln Met Ala Glu Leu Arg Ile Leu
        2515                2520                2525            
Arg Leu Met Pro Ala Asp Ala Gly Val Tyr Arg Cys Gln Ala Gly Ser
    2530                2535                2540                
Ala His Ser Ser Thr Glu Val Thr Val Glu Ala Arg Glu Val Thr Val
2545                2550                2555                2560
Thr Gly Pro Leu Gln Asp Ala Glu Ala Thr Glu Glu Gly Trp Ala Ser
                2565                2570                2575    
Phe Ser Cys Glu Leu Ser His Glu Asp Glu Glu Val Glu Trp Ser Leu
            2580                2585                2590        
Asn Gly Met Pro Leu Tyr Asn Asp Ser Phe His Glu Ile Ser His Lys
        2595                2600                2605            
Gly Arg Arg His Thr Leu Val Leu Lys Ser Ile Gln Arg Ala Asp Ala
    2610                2615                2620                
Gly Ile Val Arg Ala Ser Ser Leu Lys Val Ser Thr Ser Ala Arg Leu
2625                2630                2635                2640
Glu Val Arg Val Lys Pro Val Val Phe Leu Lys Ala Leu Asp Asp Leu
                2645                2650                2655    
Ser Ala Glu Glu Arg Gly Thr Leu Ala Leu Gln Cys Glu Val Ser Asp
            2660                2665                2670        
Pro Glu Ala His Val Val Trp Arg Lys Asp Gly Val Gln Leu Gly Pro
        2675                2680                2685            
Ser Asp Lys Tyr Asp Phe Leu His Thr Ala Gly Thr Arg Gly Leu Val
    2690                2695                2700                
Val His Asp Val Ser Pro Glu Asp Ala Gly Leu Tyr Thr Cys His Val
2705                2710                2715                2720
Gly Ser Glu Glu Thr Arg Ala Arg Val Arg Val His Asp Leu His Val
                2725                2730                2735    
Gly Ile Thr Lys Arg Leu Lys Thr Met Glu Val Leu Glu Gly Glu Ser
            2740                2745                2750        
Cys Ser Phe Glu Cys Val Leu Ser His Glu Ser Ala Ser Asp Pro Ala
        2755                2760                2765            
Met Trp Thr Val Gly Gly Lys Thr Val Gly Ser Ser Ser Arg Phe Gln
    2770                2775                2780                
Ala Thr Arg Gln Gly Arg Lys Tyr Ile Leu Val Val Arg Glu Ala Ala
2785                2790                2795                2800
Pro Ser Asp Ala Gly Glu Val Val Phe Ser Val Arg Gly Leu Thr Ser
                2805                2810                2815    
Lys Ala Ser Leu Ile Val Arg Glu Arg Pro Ala Ala Ile Ile Lys Pro
            2820                2825                2830        
Leu Glu Asp Gln Trp Val Ala Pro Gly Glu Asp Val Glu Leu Arg Cys
        2835                2840                2845            
Glu Leu Ser Arg Ala Gly Thr Pro Val His Trp Leu Lys Asp Arg Lys
    2850                2855                2860                
Ala Ile Arg Lys Ser Gln Lys Tyr Asp Val Val Cys Glu Gly Thr Met
2865                2870                2875                2880
Ala Met Leu Val Ile Arg Gly Ala Ser Leu Lys Asp Ala Gly Glu Tyr
                2885                2890                2895    
Thr Cys Glu Val Glu Ala Ser Lys Ser Thr Ala Ser Leu His Val Glu
            2900                2905                2910        
Glu Lys Ala Asn Cys Phe Thr Glu Glu Leu Thr Asn Leu Gln Val Glu
        2915                2920                2925            
Glu Lys Gly Thr Ala Val Phe Thr Cys Lys Thr Glu His Pro Ala Ala
    2930                2935                2940                
Thr Val Thr Trp Arg Lys Gly Leu Leu Glu Leu Arg Ala Ser Gly Lys
2945                2950                2955                2960
His Gln Pro Ser Gln Glu Gly Leu Thr Leu Arg Leu Thr Ile Ser Ala
                2965                2970                2975    
Leu Glu Lys Ala Asp Ser Asp Thr Tyr Thr Cys Asp Ile Gly Gln Ala
            2980                2985                2990        
Gln Ser Arg Ala Gln Leu Leu Val Gln Gly Arg Arg Val His Ile Ile
        2995                3000                3005            
Glu Asp Leu Glu Asp Val Asp Val Gln Glu Gly Ser Ser Ala Thr Phe
    3010                3015                3020                
Arg Cys Arg Ile Ser Pro Ala Asn Tyr Glu Pro Val His Trp Phe Leu
3025                3030                3035                3040
Asp Lys Thr Pro Leu His Ala Asn Glu Leu Asn Glu Ile Asp Ala Gln
                3045                3050                3055    
Pro Gly Gly Tyr His Val Leu Thr Leu Arg Gln Leu Ala Leu Lys Asp
            3060                3065                3070        
Ser Gly Thr Ile Tyr Phe Glu Ala Gly Asp Gln Arg Ala Ser Ala Ala
        3075                3080                3085            
Leu Arg Val Thr Glu Lys Pro Ser Val Phe Ser Arg Glu Leu Thr Asp
    3090                3095                3100                
Ala Thr Ile Thr Glu Gly Glu Asp Leu Thr Leu Val Cys Glu Thr Ser
3105                3110                3115                3120
Thr Cys Asp Ile Pro Met Cys Trp Thr Lys Asp Gly Lys Thr Leu Arg
                3125                3130                3135    
Gly Ser Ala Arg Cys Gln Leu Ser His Glu Gly His Arg Ala Gln Leu
            3140                3145                3150        
Leu Ile Thr Gly Ala Thr Leu Gln Asp Ser Gly Arg Tyr Lys Cys Glu
        3155                3160                3165            
Ala Gly Gly Ala Cys Ser Ser Ser Ile Val Arg Val His Ala Arg Pro
    3170                3175                3180                
Val Arg Phe Gln Glu Ala Leu Lys Asp Leu Glu Val Leu Glu Gly Gly
3185                3190                3195                3200
Ala Ala Thr Leu Arg Cys Val Leu Ser Ser Val Ala Ala Pro Val Lys
                3205                3210                3215    
Trp Cys Tyr Gly Asn Asn Val Leu Arg Pro Gly Asp Lys Tyr Ser Leu
            3220                3225                3230        
Arg Gln Glu Gly Ala Met Leu Glu Leu Val Val Arg Asn Leu Arg Pro
        3235                3240                3245            
Gln Asp Ser Gly Arg Tyr Ser Cys Ser Phe Gly Asp Gln Thr Thr Ser
    3250                3255                3260                
Ala Thr Leu Thr Val Thr Ala Leu Pro Ala Gln Phe Ile Gly Lys Leu
3265                3270                3275                3280
Arg Asn Lys Glu Ala Thr Glu Gly Ala Thr Ala Thr Leu Arg Cys Glu
                3285                3290                3295    
Leu Ser Lys Thr Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu
            3300                3305                3310        
Arg Asp Gly Asp Arg Tyr Cys Leu Arg Gln Asp Gly Ala Met Cys Glu
        3315                3320                3325            
Leu Gln Ile Arg Gly Leu Ala Met Val Asp Ala Ala Glu Tyr Ser Cys
    3330                3335                3340                
Val Cys Gly Glu Glu Arg Thr Ser Ala Ser Leu Thr Ile Arg Pro Met
3345                3350                3355                3360
Pro Ala His Phe Ile Gly Arg Leu Arg His Gln Glu Ser Ile Glu Gly
                3365                3370                3375    
Ala Thr Ala Thr Leu Arg Cys Glu Leu Ser Lys Ala Ala Pro Val Glu
            3380                3385                3390        
Trp Arg Lys Gly Arg Glu Ser Leu Arg Asp Gly Asp Arg His Ser Leu
        3395                3400                3405            
Arg Gln Asp Gly Ala Val Cys Glu Leu Gln Ile Cys Gly Leu Ala Val
    3410                3415                3420                
Ala Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Glu Glu Arg Thr Ser
3425                3430                3435                3440
Ala Thr Leu Thr Val Lys Ala Leu Pro Ala Lys Phe Thr Glu Gly Leu
                3445                3450                3455    
Arg Asn Glu Glu Ala Val Glu Gly Ala Thr Ala Met Leu Trp Cys Glu
            3460                3465                3470        
Leu Ser Lys Val Ala Pro Val Glu Trp Arg Lys Gly Pro Glu Asn Leu
        3475                3480                3485            
Arg Asp Gly Asp Arg Tyr Ile Leu Arg Gln Glu Gly Thr Arg Cys Glu
    3490                3495                3500                
Leu Gln Ile Cys Gly Leu Ala Met Ala Asp Ala Gly Glu Tyr Leu Cys
3505                3510                3515                3520
Val Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Ile Arg Ala Leu
                3525                3530                3535    
Pro Ala Arg Phe Ile Glu Asp Val Lys Asn Gln Glu Ala Arg Glu Gly
            3540                3545                3550        
Ala Thr Ala Val Leu Gln Cys Glu Leu Asn Ser Ala Ala Pro Val Glu
        3555                3560                3565            
Trp Arg Lys Gly Ser Glu Thr Leu Arg Asp Gly Asp Arg Tyr Ser Leu
    3570                3575                3580                
Arg Gln Asp Gly Thr Lys Cys Glu Leu Gln Ile Arg Gly Leu Ala Met
3585                3590                3595                3600
Ala Asp Thr Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser
                3605                3610                3615    
Ala Met Leu Thr Val Arg Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu
            3620                3625                3630        
Arg Asn Glu Glu Ala Thr Glu Gly Ala Thr Ala Val Leu Arg Cys Glu
        3635                3640                3645            
Leu Ser Lys Met Ala Pro Val Glu Trp Trp Lys Gly His Glu Thr Leu
    3650                3655                3660                
Arg Asp Gly Asp Arg His Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu
3665                3670                3675                3680
Leu Gln Ile Arg Gly Leu Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys
                3685                3690                3695    
Met Cys Gly Lys Glu Arg Thr Ser Ala Met Leu Thr Val Arg Ala Met
            3700                3705                3710        
Pro Ser Lys Phe Ile Glu Gly Leu Arg Asn Glu Glu Ala Thr Glu Gly
        3715                3720                3725            
Asp Thr Ala Thr Leu Trp Cys Glu Leu Ser Lys Ala Ala Pro Val Glu
    3730                3735                3740                
Trp Arg Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His Ser Leu
3745                3750                3755                3760
Arg Gln Asp Gly Ser Arg Cys Glu Leu Gln Ile Arg Gly Leu Ala Val
                3765                3770                3775    
Val Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser
            3780                3785                3790        
Ala Thr Leu Thr Val Arg Ala Leu Pro Ala Arg Phe Ile Glu Asp Val
        3795                3800                3805            
Lys Asn Gln Glu Ala Arg Glu Gly Ala Thr Ala Val Leu Gln Cys Glu
    3810                3815                3820                
Leu Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu
3825                3830                3835                3840
Arg Gly Gly Asp Arg Tyr Ser Leu Arg Gln Asp Gly Thr Arg Cys Glu
                3845                3850                3855    
Leu Gln Ile His Gly Leu Ser Val Ala Asp Thr Gly Glu Tyr Ser Cys
            3860                3865                3870        
Val Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Val Arg Ala Pro
        3875                3880                3885            
Gln Pro Val Phe Arg Glu Pro Leu Gln Ser Leu Gln Ala Glu Glu Gly
    3890                3895                3900                
Ser Thr Ala Thr Leu Gln Cys Glu Leu Ser Glu Pro Thr Ala Thr Val
3905                3910                3915                3920
Val Trp Ser Lys Gly Gly Leu Gln Leu Gln Ala Asn Gly Arg Arg Glu
                3925                3930                3935    
Pro Arg Leu Gln Gly Cys Thr Ala Glu Leu Val Leu Gln Asp Leu Gln
            3940                3945                3950        
Arg Glu Asp Thr Gly Glu Tyr Thr Cys Thr Cys Gly Ser Gln Ala Thr
        3955                3960                3965            
Ser Ala Thr Leu Thr Val Thr Ala Ala Pro Val Arg Phe Leu Arg Glu
    3970                3975                3980                
Leu Gln His Gln Glu Val Asp Glu Gly Gly Thr Ala His Leu Cys Cys
3985                3990                3995                4000
Glu Leu Ser Arg Ala Gly Ala Ser Val Glu Trp Arg Lys Gly Ser Leu
                4005                4010                4015    
Gln Leu Phe Pro Cys Ala Lys Tyr Gln Met Val Gln Asp Gly Ala Ala
            4020                4025                4030        
Ala Glu Leu Leu Val Arg Gly Val Glu Gln Glu Asp Ala Gly Asp Tyr
        4035                4040                4045            
Thr Cys Asp Thr Gly His Thr Gln Ser Met Ala Ser Leu Ser Val Arg
    4050                4055                4060                
Val Pro Arg Pro Lys Phe Lys Thr Arg Leu Gln Ser Leu Glu Gln Glu
4065                4070                4075                4080
Thr Gly Asp Ile Ala Arg Leu Cys Cys Gln Leu Ser Asp Ala Glu Ser
                4085                4090                4095    
Gly Ala Val Val Gln Trp Leu Lys Glu Gly Val Glu Leu His Ala Gly
            4100                4105                4110        
Pro Lys Tyr Glu Met Arg Ser Gln Gly Ala Thr Arg Glu Leu Leu Ile
        4115                4120                4125            
His Gln Leu Glu Ala Lys Asp Thr Gly Glu Tyr Ala Cys Val Thr Gly
    4130                4135                4140                
Gly Gln Lys Thr Ala Ala Ser Leu Arg Val Thr Glu Pro Glu Val Thr
4145                4150                4155                4160
Ile Val Arg Gly Leu Val Asp Ala Glu Val Thr Ala Asp Glu Asp Val
                4165                4170                4175    
Glu Phe Ser Cys Glu Val Ser Arg Ala Gly Ala Thr Gly Val Gln Trp
            4180                4185                4190        
Cys Leu Gln Gly Leu Pro Leu Gln Ser Asn Glu Val Thr Glu Val Ala
        4195                4200                4205            
Val Arg Asp Gly Arg Ile His Thr Leu Arg Leu Lys Gly Val Thr Pro
    4210                4215                4220                
Glu Asp Ala Gly Thr Val Ser Phe His Leu Gly Asn His Ala Ser Ser
4225                4230                4235                4240
Ala Gln Leu Thr Val Arg Ala Pro Glu Val Thr Ile Leu Glu Pro Leu
                4245                4250                4255    
Gln Asp Val Gln Leu Ser Glu Gly Gln Asp Ala Ser Phe Gln Cys Arg
            4260                4265                4270        
Leu Ser Arg Ala Ser Gly Gln Glu Ala Arg Trp Ala Leu Gly Gly Val
        4275                4280                4285            
Pro Leu Gln Ala Asn Glu Met Asn Asp Ile Thr Val Glu Gln Gly Thr
    4290                4295                4300                
Leu His Leu Leu Thr Leu His Lys Val Thr Leu Glu Asp Ala Gly Thr
4305                4310                4315                4320
Val Ser Phe His Val Gly Thr Cys Ser Ser Glu Ala Gln Leu Lys Val
                4325                4330                4335    
Thr Ala Lys Asn Thr Val Val Arg Gly Leu Glu Asn Val Glu Ala Leu
            4340                4345                4350        
Glu Gly Gly Glu Ala Leu Phe Glu Cys Gln Leu Ser Gln Pro Glu Val
        4355                4360                4365            
Ala Ala His Thr Trp Leu Leu Asp Asp Glu Pro Val Arg Thr Ser Glu
    4370                4375                4380                
Asn Ala Glu Val Val Phe Phe Glu Asn Gly Leu Arg His Leu Leu Leu
4385                4390                4395                4400
Leu Lys Asn Leu Arg Pro Gln Asp Ser Cys Arg Val Thr Phe Leu Ala
                4405                4410                4415    
Gly Asp Met Val Thr Ser Ala Phe Leu Thr Val Arg Gly Trp Arg Leu
            4420                4425                4430        
Glu Ile Leu Glu Pro Leu Lys Asn Ala Ala Val Arg Ala Gly Ala Gln
        4435                4440                4445            
Ala Arg Phe Thr Cys Thr Leu Ser Glu Ala Val Pro Val Gly Glu Ala
    4450                4455                4460                
Ser Trp Tyr Ile Asn Gly Ala Ala Val Gln Pro Asp Asp Ser Asp Trp
4465                4470                4475                4480
Thr Val Thr Ala Asp Gly Ser His Gln Ala Leu Leu Leu Arg Ser Ala
                4485                4490                4495    
Gln Pro His His Ala Gly Glu Val Thr Phe Ala Cys Arg Asp Ala Val
            4500                4505                4510        
Ala Ser Ala Arg Leu Thr Val Leu Gly Leu Pro Asp Pro Pro Glu Asp
        4515                4520                4525            
Ala Glu Val Val Ala His Ser Ser His Thr Val Thr Leu Ser Trp Ala
    4530                4535                4540                
Ala Pro Met Ser Asp Gly Gly Gly Gly Leu Cys Gly Tyr Arg Val Glu
4545                4550                4555                4560
Val Lys Glu Gly Ala Thr Gly Gln Trp Arg Leu Cys His Glu Leu Val
                4565                4570                4575    
Pro Gly Pro Glu Cys Val Val Asp Gly Leu Ala Pro Gly Glu Thr Tyr
            4580                4585                4590        
Arg Phe Arg Val Ala Ala Val Gly Pro Val Gly Ala Gly Glu Pro Val
        4595                4600                4605            
His Leu Pro Gln Thr Val Arg Leu Ala Glu Pro Pro Lys Pro Val Pro
    4610                4615                4620                
Pro Gln Pro Ser Ala Pro Glu Ser Arg Gln Val Ala Ala Gly Glu Asp
4625                4630                4635                4640
Val Ser Leu Glu Leu Glu Val Val Ala Glu Ala Gly Glu Val Ile Trp
                4645                4650                4655    
His Lys Gly Met Glu Arg Ile Gln Pro Gly Gly Arg Phe Glu Val Val
            4660                4665                4670        
Ser Gln Gly Arg Gln Gln Met Leu Val Ile Lys Gly Phe Thr Ala Glu
        4675                4680                4685            
Asp Gln Gly Glu Tyr His Cys Gly Leu Ala Gln Gly Ser Ile Cys Pro
    4690                4695                4700                
Ala Ala Ala Thr Phe Gln Val Ala Leu Ser Pro Ala Ser Val Asp Glu
4705                4710                4715                4720
Ala Pro Gln Pro Ser Leu Pro Pro Glu Ala Ala Gln Glu Gly Asp Leu
                4725                4730                4735    
His Leu Leu Trp Glu Ala Leu Ala Arg Lys Arg Arg Met Ser Arg Glu
            4740                4745                4750        
Pro Thr Leu Asp Ser Ile Ser Glu Leu Pro Glu Glu Asp Gly Arg Ser
        4755                4760                4765            
Gln Arg Leu Pro Gln Glu Ala Glu Glu Val Ala Pro Asp Leu Ser Glu
    4770                4775                4780                
Gly Tyr Ser Thr Ala Asp Glu Leu Ala Arg Thr Gly Asp Ala Asp Leu
4785                4790                4795                4800
Ser His Thr Ser Ser Asp Asp Glu Ser Arg Ala Gly Thr Pro Ser Leu
                4805                4810                4815    
Val Thr Tyr Leu Lys Lys Ala Gly Arg Pro Gly Thr Ser Pro Leu Ala
            4820                4825                4830        
Ser Lys Val Gly Ala Pro Ala Ala Pro Ser Val Lys Pro Gln Gln Gln
        4835                4840                4845            
Gln Glu Pro Leu Ala Ala Val Arg Pro Pro Leu Gly Asp Leu Ser Thr
    4850                4855                4860                
Lys Asp Leu Gly Asp Pro Ser Met Asp Lys Ala Ala Val Lys Ile Gln
4865                4870                4875                4880
Ala Ala Phe Lys Gly Tyr Lys Val Arg Lys Glu Met Lys Gln Gln Glu
                4885                4890                4895    
Gly Pro Met Phe Ser His Thr Phe Gly Asp Thr Glu Ala Gln Val Gly
            4900                4905                4910        
Asp Ala Leu Arg Leu Glu Cys Val Val Ala Ser Lys Ala Asp Val Arg
        4915                4920                4925            
Ala Arg Trp Leu Lys Asp Gly Val Glu Leu Thr Asp Gly Arg His His
    4930                4935                4940                
His Ile Asp Gln Leu Gly Asp Gly Thr Cys Ser Leu Leu Ile Ala Gly
4945                4950                4955                4960
Leu Asp Arg Ala Asp Ala Gly Cys Tyr Thr Cys Gln Val Ser Asn Lys
                4965                4970                4975    
Phe Gly Gln Val Thr His Ser Ala Cys Val Val Val Ser Gly Ser Glu
            4980                4985                4990        
Ser Glu Ala Glu Ser Ser Ser Gly Gly Glu Leu Asp Asp Ala Phe Arg
        4995                5000                5005            
Arg Ala Ala Arg Arg Leu His Arg Leu Phe Arg Thr Lys Ser Pro Ala
    5010                5015                5020                
Glu Val Ser Asp Glu Glu Leu Phe Leu Ser Ala Asp Glu Gly Pro Ala
5025                5030                5035                5040
Glu Pro Glu Glu Pro Ala Asp Trp Gln Thr Tyr Arg Glu Asp Glu His
                5045                5050                5055    
Phe Ile Cys Ile Arg Phe Glu Ala Leu Thr Glu Ala Arg Gln Ala Val
            5060                5065                5070        
Thr Arg Phe Gln Glu Met Phe Ala Thr Leu Gly Ile Gly Val Glu Ile
        5075                5080                5085            
Lys Leu Val Glu Gln Gly Pro Arg Arg Val Glu Met Cys Ile Ser Lys
    5090                5095                5100                
Glu Thr Pro Ala Pro Val Val Pro Pro Glu Pro Leu Pro Ser Leu Leu
5105                5110                5115                5120
Thr Ser Asp Ala Ala Pro Val Phe Leu Thr Glu Leu Gln Asn Gln Glu
                5125                5130                5135    
Val Gln Asp Gly Tyr Pro Val Ser Phe Asp Cys Val Val Thr Gly Gln
            5140                5145                5150        
Pro Met Pro Ser Val Arg Trp Phe Lys Asp Gly Lys Leu Leu Glu Glu
        5155                5160                5165            
Asp Asp His Tyr Met Ile Asn Glu Asp Gln Gln Gly Gly His Gln Leu
    5170                5175                5180                
Ile Ile Thr Ala Val Val Pro Ala Asp Met Gly Val Tyr Arg Cys Leu
5185                5190                5195                5200
Ala Glu Asn Ser Met Gly Val Ser Ser Thr Lys Ala Glu Leu Arg Val
                5205                5210                5215    
Asp Leu Thr Ser Thr Asp Tyr Asp Thr Ala Ala Asp Ala Thr Glu Ser
            5220                5225                5230        
Ser Ser Tyr Phe Ser Ala Gln Gly Tyr Leu Ser Ser Arg Glu Gln Glu
        5235                5240                5245            
Gly Thr Glu Ser Thr Thr Asp Glu Gly Gln Leu Pro Gln Val Val Glu
    5250                5255                5260                
Glu Leu Arg Asp Leu Gln Val Ala Pro Gly Thr Arg Leu Ala Lys Phe
5265                5270                5275                5280
Gln Leu Lys Val Lys Gly Tyr Pro Ala Pro Arg Leu Tyr Trp Phe Lys
                5285                5290                5295    
Asp Gly Gln Pro Leu Thr Ala Ser Ala His Ile Arg Met Thr Asp Lys
            5300                5305                5310        
Lys Ile Leu His Thr Leu Glu Ile Ile Ser Val Thr Arg Glu Asp Ser
        5315                5320                5325            
Gly Gln Tyr Ala Ala Tyr Ile Ser Asn Ala Met Gly Ala Ala Tyr Ser
    5330                5335                5340                
Ser Ala Arg Leu Leu Val Arg Gly Pro Asp Glu Pro Glu Glu Lys Pro
5345                5350                5355                5360
Ala Ser Asp Val His Glu Gln Leu Val Pro Pro Arg Met Leu Glu Arg
                5365                5370                5375    
Phe Thr Pro Lys Lys Val Lys Lys Gly Ser Ser Ile Thr Phe Ser Val
            5380                5385                5390        
Lys Val Glu Gly Arg Pro Val Pro Thr Val His Trp Leu Arg Glu Glu
        5395                5400                5405            
Ala Glu Arg Gly Val Leu Trp Ile Gly Pro Asp Thr Pro Gly Tyr Thr
    5410                5415                5420                
Val Ala Ser Ser Ala Gln Gln His Ser Leu Val Leu Leu Asp Val Gly
5425                5430                5435                5440
Arg Gln His Gln Gly Thr Tyr Thr Cys Ile Ala Ser Asn Ala Ala Gly
                5445                5450                5455    
Gln Ala Leu Cys Ser Ala Ser Leu His Val Ser Gly Leu Pro Lys Val
            5460                5465                5470        
Glu Glu Gln Glu Lys Val Lys Glu Ala Leu Ile Ser Thr Phe Leu Gln
        5475                5480                5485            
Gly Thr Thr Gln Ala Ile Ser Ala Gln Gly Phe Gln Thr Ala Ser Phe
    5490                5495                5500                
Ala Asp Leu Gly Gly Gln Arg Lys Glu Glu Pro Leu Ala Ala Lys Glu
5505                5510                5515                5520
Ala Leu Gly His Leu Ser Leu Ala Glu Val Gly Thr Glu Glu Phe Leu
                5525                5530                5535    
Gln Lys Leu Thr Ser Gln Ile Thr Glu Met Val Ser Ala Lys Ile Thr
            5540                5545                5550        
Gln Ala Lys Leu Gln Val Pro Gly Gly Asp Ser Asp Glu Asp Ser Lys
        5555                5560                5565            
Thr Pro Ser Ala Ser Pro Arg His Gly Arg Ser Arg Pro Ser Ser Ser
    5570                5575                5580                
Ile Gln Glu Ser Ser Ser Glu Ser Glu Asp Gly Asp Ala Arg Gly Glu
5585                5590                5595                5600
Ile Phe Asp Ile Tyr Val Val Thr Ala Asp Tyr Leu Pro Leu Gly Ala
                5605                5610                5615    
Glu Gln Asp Ala Ile Thr Leu Arg Glu Gly Gln Tyr Val Glu Val Leu
            5620                5625                5630        
Asp Ala Ala His Pro Leu Arg Trp Leu Val Arg Thr Lys Pro Thr Lys
        5635                5640                5645            
Ser Ser Pro Ser Arg Gln Gly Trp Val Ser Pro Ala Tyr Leu Asp Arg
    5650                5655                5660                
Arg Leu Lys Leu Ser Pro Glu Trp Gly Ala Ala Glu Ala Pro Glu Phe
5665                5670                5675                5680
Pro Gly Glu Ala Val Ser Glu Asp Glu Tyr Lys Ala Arg Leu Ser Ser
                5685                5690                5695    
Val Ile Gln Glu Leu Leu Ser Ser Glu Gln Ala Phe Val Glu Glu Leu
            5700                5705                5710        
Gln Phe Leu Gln Ser His His Leu Gln His Leu Glu Arg Cys Pro His
        5715                5720                5725            
Val Pro Ile Ala Val Ala Gly Gln Lys Ala Val Ile Phe Arg Asn Val
    5730                5735                5740                
Arg Asp Ile Gly Arg Phe His Ser Ser Phe Leu Gln Glu Leu Gln Gln
5745                5750                5755                5760
Cys Asp Thr Asp Asp Asp Val Ala Met Cys Phe Ile Lys Asn Gln Ala
                5765                5770                5775    
Ala Phe Glu Gln Tyr Leu Glu Phe Leu Val Gly Arg Val Gln Ala Glu
            5780                5785                5790        
Ser Val Val Val Ser Thr Ala Ile Gln Glu Phe Tyr Lys Lys Tyr Ala
        5795                5800                5805            
Glu Glu Ala Leu Leu Ala Gly Asp Pro Ser Gln Pro Pro Pro Pro Pro
    5810                5815                5820                
Leu Gln His Tyr Leu Glu Gln Pro Val Glu Arg Val Gln Arg Tyr Gln
5825                5830                5835                5840
Ala Leu Leu Lys Glu Leu Ile Arg Asn Lys Ala Arg Asn Arg Gln Asn
                5845                5850                5855    
Cys Ala Leu Leu Glu Gln Ala Tyr Ala Val Val Ser Ala Leu Pro Gln
            5860                5865                5870        
Arg Ala Glu Asn Lys Leu His Val Ser Leu Met Glu Asn Tyr Pro Gly
        5875                5880                5885            
Thr Leu Gln Ala Leu Gly Glu Pro Ile Arg Gln Gly His Phe Ile Val
    5890                5895                5900                
Trp Glu Gly Ala Pro Gly Ala Arg Met Pro Trp Lys Gly His Asn Arg
5905                5910                5915                5920
His Val Phe Leu Phe Arg Asn His Leu Val Ile Cys Lys Pro Arg Arg
                5925                5930                5935    
Asp Ser Arg Thr Asp Thr Val Ser Tyr Val Phe Arg Asn Met Met Lys
            5940                5945                5950        
Leu Ser Ser Ile Asp Leu Asn Asp Gln Val Glu Gly Asp Asp Arg Ala
        5955                5960                5965            
Phe Glu Val Trp Gln Glu Arg Glu Asp Ser Val Arg Lys Tyr Leu Leu
    5970                5975                5980                
Gln Ala Arg Thr Ala Ile Ile Lys Ser Ser Trp Val Lys Glu Ile Cys
5985                5990                5995                6000
Gly Ile Gln Gln Arg Leu Ala Leu Pro Val Trp Arg Pro Pro Asp Phe
                6005                6010                6015    
Glu Glu Glu Leu Ala Asp Cys Thr Ala Glu Leu Gly Glu Thr Val Lys
            6020                6025                6030        
Leu Ala Cys Arg Val Thr Gly Thr Pro Lys Pro Val Ile Ser Trp Tyr
        6035                6040                6045            
Lys Asp Gly Lys Ala Val Gln Val Asp Pro His His Ile Leu Ile Glu
    6050                6055                6060                
Asp Pro Asp Gly Ser Cys Ala Leu Ile Leu Asp Ser Leu Thr Gly Val
6065                6070                6075                6080
Asp Ser Gly Gln Tyr Met Cys Phe Ala Ala Ser Ala Ala Gly Asn Cys
                6085                6090                6095    
Ser Thr Leu Gly Lys Ile Leu Val Gln Val Pro Pro Arg Phe Val Asn
            6100                6105                6110        
Lys Val Leu Ala Ser Pro Phe Val Glu Gly Glu Asp Ala Gln Phe Thr
        6115                6120                6125            
Cys Thr Ile Glu Gly Ala Pro Tyr Pro Gln Ile Arg Trp Tyr Lys Asp
    6130                6135                6140                
Gly Ala Leu Leu Thr Thr Gly Asn Lys Phe Gln Thr Leu Ser Glu Pro
6145                6150                6155                6160
Arg Ser Gly Leu Leu Val Leu Val Ile Arg Ala Ala Ser Lys Glu Asp
                6165                6170                6175    
Leu Gly Leu Tyr Glu Cys Glu Leu Val Asn Arg Leu Gly Ser Ala Arg
            6180                6185                6190        
Ala Ser Ala Glu Leu Arg Ile Gln Ser Pro Met Leu Gln Ala Gln Glu
        6195                6200                6205            
Gln Cys His Arg Glu Gln Leu Val Ala Ala Val Glu Val Thr Glu Gln
    6210                6215                6220                
Glu Thr Lys Val Pro Lys Lys Thr Val Ile Ile Glu Glu Thr Ile Thr
6225                6230                6235                6240
Thr Val Val Lys Ser Pro Arg Gly Gln Arg Arg Ser Pro Ser Lys Ser
                6245                6250                6255    
Pro Ser Arg Ser Pro Ser Arg Cys Ser Ala Ser Pro Leu Arg Pro Gly
            6260                6265                6270        
Leu Leu Ala Pro Asp Leu Leu Tyr Leu Pro Gly Ala Gly Gln Pro Arg
        6275                6280                6285            
Arg Pro Glu Ala Glu Pro Gly Gln Lys Pro Val Val Pro Thr Leu Tyr
    6290                6295                6300                
Val Thr Glu Ala Glu Ala His Ser Pro Ala Leu Pro Gly Leu Ser Gly
6305                6310                6315                6320
Pro Gln Pro Lys Trp Val Glu Val Glu Glu Thr Ile Glu Val Arg Val
                6325                6330                6335    
Lys Lys Met Gly Pro Gln Gly Val Ser Pro Thr Thr Glu Val Pro Arg
            6340                6345                6350        
Ser Ser Ser Gly His Leu Phe Thr Leu Pro Gly Ala Thr Pro Gly Gly
        6355                6360                6365            
Asp Pro Asn Ser Asn Asn Ser Asn Asn Lys Leu Leu Ala Gln Glu Ala
    6370                6375                6380                
Trp Ala Gln Gly Thr Ala Met Val Gly Val Arg Glu Pro Leu Val Phe
6385                6390                6395                6400
Arg Val Asp Ala Arg Gly Ser Val Asp Trp Ala Ala Ser Gly Met Gly
                6405                6410                6415    
Ser Leu Glu Glu Glu Gly Thr Met Glu Glu Ala Gly Glu Glu Glu Gly
            6420                6425                6430        
Glu Asp Gly Asp Ala Phe Val Thr Glu Glu Ser Gln Asp Thr His Ser
        6435                6440                6445            
Leu Gly Asp Arg Asp Pro Lys Ile Leu Thr His Asn Gly Arg Met Leu
    6450                6455                6460                
Thr Leu Ala Asp Leu Glu Asp Tyr Val Pro Gly Glu Gly Glu Thr Phe
6465                6470                6475                6480
His Cys Gly Gly Pro Gly Pro Gly Ala Pro Asp Asp Pro Pro Cys Glu
                6485                6490                6495    
Val Ser Val Ile Gln Arg Glu Ile Gly Glu Pro Thr Val Gly Gln Pro
            6500                6505                6510        
Val Leu Leu Ser Val Gly His Ala Leu Gly Pro Arg Gly Pro Leu Gly
        6515                6520                6525            
Leu Phe Arg Pro Glu Pro Arg Gly Ala Ser Pro Pro Gly Pro Gln Val
    6530                6535                6540                
Arg Ser Leu Glu Gly Thr Ser Phe Leu Leu Arg Glu Ala Pro Ala Arg
6545                6550                6555                6560
Pro Val Gly Ser Ala Pro Trp Thr Gln Ser Phe Cys Thr Arg Ile Arg
                6565                6570                6575    
Arg Ser Ala Asp Ser Gly Gln Ser Ser Phe Thr Thr Glu Leu Ser Thr
            6580                6585                6590        
Gln Thr Val Asn Phe Gly Thr Val Gly Glu Thr Val Thr Leu His Ile
        6595                6600                6605            
Cys Pro Asp Arg Asp Gly Asp Glu Ala Ala Gln Pro
    6610                6615                6620


<210> 6610
<211> 718
<212> PRT
<213> Homo sapiens

<400> 6610
Met Arg Ala Val Leu Asp Thr Ala Asp Ile Ala Ile Val Ala Leu Tyr
 1               5                  10                  15      
Phe Ile Leu Val Met Cys Ile Gly Phe Phe Ala Met Trp Lys Ser Asn
            20                  25                  30          
Arg Ser Thr Val Ser Gly Tyr Phe Leu Ala Gly Arg Ser Met Thr Trp
        35                  40                  45              
Val Thr Ile Gly Ala Ser Leu Phe Val Ser Asn Ile Gly Ser Glu His
    50                  55                  60                  
Phe Ile Gly Leu Ala Gly Ser Gly Ala Ala Ser Gly Phe Ala Val Gly
65                  70                  75                  80  
Ala Trp Glu Phe Asn Ala Leu Leu Leu Leu Gln Leu Leu Gly Trp Val
                85                  90                  95      
Phe Ile Pro Ile Tyr Ile Arg Ser Gly Val Tyr Thr Met Pro Glu Tyr
            100                 105                 110         
Leu Ser Lys Arg Phe Gly Gly His Arg Ile Gln Val Tyr Phe Ala Ala
        115                 120                 125             
Leu Ser Leu Ile Leu Tyr Ile Phe Thr Lys Leu Ser Val Asp Leu Tyr
    130                 135                 140                 
Ser Gly Ala Leu Phe Ile Gln Glu Ser Leu Gly Trp Asn Leu Tyr Val
145                 150                 155                 160 
Ser Val Ile Leu Leu Ile Gly Met Thr Ala Leu Leu Thr Val Thr Gly
                165                 170                 175     
Gly Leu Val Ala Val Ile Tyr Thr Asp Thr Leu Gln Ala Leu Leu Met
            180                 185                 190         
Ile Ile Gly Ala Leu Thr Leu Met Ile Ile Ser Ile Met Glu Ile Gly
        195                 200                 205             
Gly Phe Glu Glu Val Lys Arg Arg Tyr Met Leu Ala Ser Pro Asp Val
    210                 215                 220                 
Thr Ser Ile Leu Leu Thr Tyr Asn Leu Ser Asn Thr Asn Ser Cys Asn
225                 230                 235                 240 
Val Ser Pro Lys Lys Glu Ala Leu Lys Met Leu Arg Asn Pro Thr Asp
                245                 250                 255     
Glu Asp Val Pro Trp Pro Gly Phe Ile Leu Gly Gln Thr Pro Ala Ser
            260                 265                 270         
Val Trp Tyr Trp Cys Ala Asp Gln Val Ile Val Gln Arg Val Leu Ala
        275                 280                 285             
Ala Lys Asn Ile Ala His Ala Lys Gly Ser Thr Leu Met Ala Gly Phe
    290                 295                 300                 
Leu Lys Leu Leu Pro Met Phe Ile Ile Val Val Pro Gly Met Ile Ser
305                 310                 315                 320 
Arg Ile Leu Phe Thr Asp Asp Ile Ala Cys Ile Asn Pro Glu His Cys
                325                 330                 335     
Met Leu Val Cys Gly Ser Arg Ala Gly Cys Ser Asn Ile Ala Tyr Pro
            340                 345                 350         
Arg Leu Val Met Lys Leu Val Pro Val Gly Leu Arg Gly Leu Met Met
        355                 360                 365             
Ala Val Met Ile Ala Ala Leu Met Ser Asp Leu Asp Ser Ile Phe Asn
    370                 375                 380                 
Ser Ala Ser Thr Ile Phe Thr Leu Asp Val Tyr Lys Leu Ile Arg Lys
385                 390                 395                 400 
Ser Ala Ser Ser Arg Glu Leu Met Ile Val Gly Arg Ile Phe Val Ala
                405                 410                 415     
Phe Met Val Val Ile Ser Ile Ala Trp Val Pro Ile Ile Val Glu Met
            420                 425                 430         
Gln Gly Gly Gln Met Tyr Leu Tyr Ile Gln Glu Val Ala Asp Tyr Leu
        435                 440                 445             
Thr Pro Pro Val Ala Ala Leu Phe Leu Leu Ala Ile Phe Trp Lys Arg
    450                 455                 460                 
Cys Asn Glu Gln Gly Ala Phe Tyr Gly Gly Met Ala Gly Phe Val Leu
465                 470                 475                 480 
Gly Ala Val Arg Leu Ile Leu Ala Phe Ala Tyr Arg Ala Pro Glu Cys
                485                 490                 495     
Asp Gln Pro Asp Asn Arg Pro Gly Phe Ile Lys Asp Ile His Tyr Met
            500                 505                 510         
Tyr Val Ala Thr Gly Leu Phe Trp Val Thr Gly Leu Ile Thr Val Ile
        515                 520                 525             
Val Ser Leu Leu Thr Pro Pro Pro Thr Lys Glu Gln Ile Arg Thr Thr
    530                 535                 540                 
Thr Phe Trp Ser Lys Lys Asn Leu Val Val Lys Glu Asn Cys Ser Pro
545                 550                 555                 560 
Lys Glu Glu Pro Tyr Gln Met Gln Glu Lys Ser Ile Leu Arg Cys Ser
                565                 570                 575     
Glu Asn Asn Glu Thr Ile Asn His Ile Ile Pro Asn Gly Lys Ser Glu
            580                 585                 590         
Asp Ser Ile Lys Gly Leu Gln Pro Glu Asp Val Asn Leu Leu Val Thr
        595                 600                 605             
Cys Arg Glu Glu Gly Asn Pro Val Ala Ser Leu Gly His Ser Glu Ala
    610                 615                 620                 
Glu Thr Pro Val Asp Ala Tyr Ser Asn Gly Gln Ala Ala Leu Met Gly
625                 630                 635                 640 
Glu Lys Glu Arg Lys Lys Glu Thr Asp Asp Gly Gly Arg Tyr Trp Lys
                645                 650                 655     
Phe Ile Asp Trp Phe Cys Gly Phe Lys Ser Lys Ser Leu Ser Lys Arg
            660                 665                 670         
Ser Leu Arg Asp Leu Met Glu Glu Glu Ala Val Cys Leu Gln Met Leu
        675                 680                 685             
Glu Glu Thr Arg Gln Val Lys Val Ile Leu Asn Ile Gly Leu Phe Ala
    690                 695                 700                 
Val Cys Ser Leu Gly Ile Phe Met Phe Val Tyr Phe Ser Leu
705                 710                 715             


<210> 6611
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 6611
Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly
 1               5                  10                  15      
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr
            20                  25                  30          
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp
        35                  40                  45              
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg
    50                  55                  60                  
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val
65                  70                  75                  80  
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile
                85                  90                  95      
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu
            100                 105                 110         
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala
        115                 120                 125             
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser
    130                 135                 140                 
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu
145                 150                 155                 160 
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val
                165                 170                 175     
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp
            180                 185                 190         
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu
        195                 200                 205             
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp
    210                 215                 220                 
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val
225                 230                 235                 240 
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val
                245                 250                 255     
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr
            260                 265                 270         
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val
        275                 280                 285             
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly
    290                 295                 300                 
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala
305                 310                 315                 320 
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Val
                325                 330                 335     
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu
            340                 345                 350         
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr
        355                 360                 365             
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp
    370                 375                 380                 
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser
385                 390                 395                 400 
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly
                405                 410                 415     
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val
            420                 425                 430         
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys
        435                 440                 445             
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn
    450                 455                 460                 
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu
465                 470                 475                 480 
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val
                485                 490                 495     
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu
            500                 505                 510         
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe
        515                 520                 525             
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly
    530                 535                 540                 
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala
545                 550                 555                 560 
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val
                565                 570                 575     
Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala
            580                 585                 590         
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly
        595                 600                 605             
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile
    610                 615                 620                 
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile
625                 630                 635                 640 
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His
                645                 650                 655     
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu
            660                 665                 670         
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys
        675                 680                 685             
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val
    690                 695                 700                 
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile
705                 710                 715                 720 
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala
                725                 730                 735     
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val
            740                 745                 750         
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr
        755                 760                 765             
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile
    770                 775                 780                 
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile
785                 790                 795                 800 
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala
                805                 810                 815     
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp
            820                 825                 830         
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly
        835                 840                 845             
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala
    850                 855                 860                 
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp
865                 870                 875                 880 
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp
                885                 890                 895     
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe
            900                 905                 910         
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys
        915                 920                 925             
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu
    930                 935                 940                 
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr
945                 950                 955                 960 
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser
                965                 970                 975     
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp
            980                 985                 990         
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu
        995                 1000                1005            
Lys Glu Thr Tyr Tyr
    1010            


<210> 6612
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 6612
Met His Gln Leu Phe Gln Lys Thr Pro Glu Ile Tyr Ser Val Glu Leu
 1               5                  10                  15      
Ser Gly Thr Lys Asp Ile Val Lys Thr Asp Lys Gly Asp Gly Lys Glu
            20                  25                  30          
Lys Tyr Arg Gly Leu Lys Asn Asn Cys Leu Glu Leu Lys Lys Lys Asn
        35                  40                  45              
His Lys Glu Glu Phe Gln Lys Glu Leu His Leu Asp Asp His Lys Leu
    50                  55                  60                  
Ser Asn Arg Glu Leu Glu Glu Lys Tyr Gly Thr Asp Ile Ile Met Gly
65                  70                  75                  80  
Leu Ser Ser Thr Arg Ala Ala Glu Leu Leu Ala Arg Asp Gly Pro Asn
                85                  90                  95      
Ser Leu Thr Pro Pro Lys Gln Thr Pro Glu Ile Val Lys Phe Leu Lys
            100                 105                 110         
Gln Met Val Gly Gly Phe Ser Ile Leu Leu Trp Val Gly Ala Phe Leu
        115                 120                 125             
Cys Trp Ile Ala Tyr Gly Ile Gln Tyr Ser Ser Asp Lys Ser Ala Ser
    130                 135                 140                 
Leu Asn Asn Val Tyr Leu Gly Cys Val Leu Gly Leu Val Val Ile Leu
145                 150                 155                 160 
Thr Gly Ile Phe Ala Tyr Tyr Gln Glu Ala Lys Ser Thr Asn Ile Met
                165                 170                 175     
Ser Ser Phe Asn Lys Met Ile Pro Gln Gln Ala Leu Val Ile Arg Asp
            180                 185                 190         
Ser Glu Lys Lys Thr Ile Pro Ser Glu Gln Leu Val Val Gly Asp Ile
        195                 200                 205             
Val Glu Val Lys Gly Gly Asp Gln Ile Pro Ala Asp Ile Arg Val Leu
    210                 215                 220                 
Ser Ser Gln Gly Cys Arg Val Asp Asn Ser Ser Leu Thr Gly Glu Ser
225                 230                 235                 240 
Glu Pro Gln Pro Arg Ser Ser Glu Phe Thr His Glu Asn Pro Leu Glu
                245                 250                 255     
Thr Lys Asn Ile Cys Phe Tyr Ser Thr Thr Cys Leu Glu Gly Thr Val
            260                 265                 270         
Thr Gly Met Val Ile Asn Thr Gly Asp Arg Thr Ile Ile Gly His Ile
        275                 280                 285             
Ala Ser Leu Ala Ser Gly Val Gly Asn Glu Lys Thr Pro Ile Ala Ile
    290                 295                 300                 
Glu Ile Glu His Phe Val His Ile Val Ala Gly Val Ala Val Ser Ile
305                 310                 315                 320 
Gly Ile Leu Phe Phe Ile Ile Ala Val Ser Leu Lys Tyr Gln Val Leu
                325                 330                 335     
Asp Ser Ile Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu
            340                 345                 350         
Gly Leu Leu Ala Thr Val Thr Val Thr Leu Ser Leu Thr Ala Lys Arg
        355                 360                 365             
Met Ala Lys Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr
    370                 375                 380                 
Leu Gly Ser Thr Ser Ile Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr
385                 390                 395                 400 
Gln Asn Arg Met Thr Val Ala His Leu Trp Phe Asp Asn Gln Ile Phe
                405                 410                 415     
Val Ala Asp Thr Ser Glu Asp His Ser Asn Gln Val Phe Asp Gln Ser
            420                 425                 430         
Ser Arg Thr Trp Ala Ser Leu Ser Lys Ile Ile Thr Leu Cys Asn Arg
        435                 440                 445             
Ala Glu Phe Lys Pro Gly Gln Glu Asn Val Pro Ile Met Lys Lys Ala
    450                 455                 460                 
Val Ile Gly Asp Ala Ser Glu Thr Ala Leu Leu Lys Phe Ser Glu Val
465                 470                 475                 480 
Ile Leu Gly Asp Val Met Glu Ile Arg Lys Arg Asn Arg Lys Val Ala
                485                 490                 495     
Glu Ile Pro Phe Asn Ser Thr Asn Lys Phe Gln Leu Ser Ile His Glu
            500                 505                 510         
Met Asp Asp Pro His Gly Lys Arg Phe Leu Met Val Met Lys Gly Ala
        515                 520                 525             
Pro Glu Arg Ile Leu Glu Lys Cys Ser Thr Ile Met Ile Asn Gly Glu
    530                 535                 540                 
Glu His Pro Leu Asp Lys Ser Thr Ala Lys Thr Phe His Thr Ala Tyr
545                 550                 555                 560 
Met Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu
                565                 570                 575     
Tyr Leu Pro Ala Asp Glu Phe Pro Glu Thr Tyr Ser Phe Asp Ile Asp
            580                 585                 590         
Ala Met Asn Phe Pro Thr Ser Asn Leu Cys Phe Val Gly Leu Leu Ser
        595                 600                 605             
Met Ile Asp Pro Pro Arg Ser Thr Val Pro Asp Ala Val Thr Lys Cys
    610                 615                 620                 
Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile
625                 630                 635                 640 
Thr Ala Lys Ala Ile Ala Lys Ser Val Gly Ile Ile Ser Ala Asn Ser
                645                 650                 655     
Glu Thr Val Glu Asp Ile Ala His Arg Leu Asn Ile Ala Val Glu Gln
            660                 665                 670         
Val Asn Lys Arg Asp Ala Lys Ala Ala Val Val Thr Gly Met Glu Leu
        675                 680                 685             
Lys Asp Met Ser Ser Glu Gln Leu Asp Glu Ile Leu Ala Asn Tyr Gln
    690                 695                 700                 
Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val
705                 710                 715                 720 
Glu Gly Cys Gln Arg Gln Asp Ala Val Val Ala Val Thr Gly Asp Gly
                725                 730                 735     
Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met
            740                 745                 750         
Gly Ile Ala Gly Ser Asp Ala Ala Lys Asn Ala Ala Asp Met Val Leu
        755                 760                 765             
Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg
    770                 775                 780                 
Leu Ile Phe Asp Asn Leu Lys Lys Thr Ile Ala Tyr Ser Leu Thr Lys
785                 790                 795                 800 
Asn Ile Ala Glu Leu Cys Pro Phe Leu Ile Tyr Ile Ile Val Gly Leu
                805                 810                 815     
Pro Leu Pro Ile Gly Thr Ile Thr Ile Leu Phe Ile Asp Leu Gly Thr
            820                 825                 830         
Asp Ile Ile Pro Ser Ile Ala Leu Ala Tyr Glu Lys Ala Glu Ser Asp
        835                 840                 845             
Ile Met Asn Arg Lys Pro Arg His Lys Asn Lys Asp Arg Leu Val Asn
    850                 855                 860                 
Gln Pro Leu Ala Val Tyr Ser Tyr Leu His Ile Gly Leu Met Gln Ala
865                 870                 875                 880 
Leu Gly Ala Phe Leu Val Tyr Phe Thr Val Tyr Ala Gln Glu Gly Phe
                885                 890                 895     
Leu Pro Arg Thr Leu Ile Asn Leu Arg Val Glu Trp Glu Lys Asp Tyr
            900                 905                 910         
Val Asn Asp Leu Lys Asp Ser Tyr Gly Gln Glu Trp Thr Arg Tyr Gln
        915                 920                 925             
Arg Glu Tyr Leu Glu Trp Thr Gly Tyr Thr Ala Phe Phe Val Gly Ile
    930                 935                 940                 
Leu Val Gln Gln Ile Ala Asp Leu Ile Ile Arg Lys Thr Arg Arg Asn
945                 950                 955                 960 
Ser Ile Phe Gln Gln Gly Leu Phe Arg Asn Lys Val Ile Trp Val Gly
                965                 970                 975     
Ile Thr Ser Gln Ile Ile Ile Gly Leu Ile Leu Ser Tyr Gly Leu Gly
            980                 985                 990         
Ser Val Thr Ala Leu Ser Phe Thr Met Leu Arg Ala Gln Tyr Trp Phe
        995                 1000                1005            
Val Ala Val Pro His Ala Ile Leu Ile Trp Val Tyr Asp Glu Val Arg
    1010                1015                1020                
Lys Leu Phe Ile Arg Leu Tyr Pro Gly Ser Trp Trp Asp Lys Asn Met
1025                1030                1035                1040
Tyr Tyr
        


<210> 6613
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 6613
Met Gly Lys Ala Glu Asn Tyr Glu Leu Tyr Ser Val Glu Leu Gly Pro
 1               5                  10                  15      
Gly Pro Gly Gly Asp Met Ala Ala Lys Met Ser Lys Lys Lys Lys Ala
            20                  25                  30          
Gly Gly Gly Gly Gly Lys Arg Lys Glu Lys Leu Glu Asn Met Lys Lys
        35                  40                  45              
Glu Met Glu Ile Asn Asp His Gln Leu Ser Val Ala Glu Leu Glu Gln
    50                  55                  60                  
Lys Tyr Gln Thr Ser Ala Thr Lys Gly Leu Ser Ala Ser Leu Ala Ala
65                  70                  75                  80  
Glu Leu Leu Leu Arg Asp Gly Pro Asn Ala Leu Arg Pro Pro Arg Gly
                85                  90                  95      
Thr Pro Glu Tyr Val Lys Phe Ala Arg Gln Leu Ala Gly Gly Leu Gln
            100                 105                 110         
Cys Leu Met Trp Val Ala Ala Ala Ile Cys Leu Ile Ala Phe Ala Ile
        115                 120                 125             
Gln Ala Ser Glu Gly Asp Leu Thr Thr Asp Asp Asn Leu Tyr Leu Ala
    130                 135                 140                 
Ile Ala Leu Ile Ala Val Val Val Val Thr Gly Cys Phe Gly Tyr Tyr
145                 150                 155                 160 
Gln Glu Phe Lys Ser Thr Asn Ile Ile Ala Ser Phe Lys Asn Leu Val
                165                 170                 175     
Pro Gln Gln Ala Thr Val Ile Arg Asp Gly Asp Lys Phe Gln Ile Asn
            180                 185                 190         
Ala Asp Gln Leu Val Val Gly Asp Leu Val Glu Met Lys Gly Gly Asp
        195                 200                 205             
Arg Val Pro Ala Asp Ile Arg Ile Leu Ala Ala Gln Gly Cys Lys Val
    210                 215                 220                 
Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro
225                 230                 235                 240 
Glu Cys Thr His Glu Ser Pro Leu Glu Thr Arg Asn Ile Ala Phe Phe
                245                 250                 255     
Ser Thr Met Cys Leu Glu Gly Thr Ala Gln Gly Leu Val Val Asn Thr
            260                 265                 270         
Gly Asp Arg Thr Ile Ile Gly Arg Ile Ala Ser Leu Ala Ser Gly Val
        275                 280                 285             
Glu Asn Glu Lys Thr Pro Ile Ala Ile Glu Ile Glu His Phe Val Asp
    290                 295                 300                 
Ile Ile Ala Gly Leu Ala Ile Leu Phe Gly Ala Thr Phe Phe Ile Val
305                 310                 315                 320 
Ala Met Cys Ile Gly Tyr Thr Phe Leu Arg Ala Met Val Phe Phe Met
                325                 330                 335     
Ala Ile Val Val Ala Tyr Val Pro Glu Gly Leu Leu Ala Thr Val Thr
            340                 345                 350         
Val Cys Leu Ser Leu Thr Ala Lys Arg Leu Ala Ser Lys Asn Cys Val
        355                 360                 365             
Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Val Ile
    370                 375                 380                 
Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ser
385                 390                 395                 400 
His Leu Trp Phe Asp Asn His Ile His Thr Ala Asp Thr Thr Glu Asp
                405                 410                 415     
Gln Ser Gly Gln Thr Phe Asp Gln Ser Ser Glu Thr Trp Arg Ala Leu
            420                 425                 430         
Cys Arg Val Leu Thr Leu Cys Asn Arg Ala Ala Phe Lys Ser Gly Gln
        435                 440                 445             
Asp Ala Val Pro Val Pro Lys Arg Ile Val Ile Gly Asp Ala Ser Glu
    450                 455                 460                 
Thr Ala Leu Leu Lys Phe Ser Glu Leu Thr Leu Gly Asn Ala Met Gly
465                 470                 475                 480 
Tyr Arg Asp Arg Phe Pro Lys Val Cys Glu Ile Pro Phe Asn Ser Thr
                485                 490                 495     
Asn Lys Phe Gln Leu Ser Ile His Thr Leu Glu Asp Pro Arg Asp Pro
            500                 505                 510         
Arg His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Val Leu Glu Arg
        515                 520                 525             
Cys Ser Ser Ile Leu Ile Lys Gly Gln Glu Leu Pro Leu Asp Glu Gln
    530                 535                 540                 
Trp Arg Glu Ala Phe Gln Thr Ala Tyr Leu Ser Leu Gly Gly Leu Gly
545                 550                 555                 560 
Glu Arg Val Leu Gly Phe Cys Gln Leu Tyr Leu Asn Glu Lys Asp Tyr
                565                 570                 575     
Pro Pro Gly Tyr Ala Phe Asp Val Glu Ala Met Asn Phe Pro Ser Ser
            580                 585                 590         
Gly Leu Cys Phe Ala Gly Leu Val Ser Met Ile Asp Pro Pro Arg Ala
        595                 600                 605             
Thr Val Pro Asp Ala Val Leu Lys Cys Arg Thr Ala Gly Ile Arg Val
    610                 615                 620                 
Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Ala
625                 630                 635                 640 
Ser Val Gly Ile Ile Ser Glu Gly Ser Glu Thr Val Glu Asp Ile Ala
                645                 650                 655     
Ala Arg Leu Arg Val Pro Val Asp Gln Val Asn Arg Lys Asp Ala Arg
            660                 665                 670         
Ala Cys Val Ile Asn Gly Met Gln Leu Lys Asp Met Asp Pro Ser Glu
        675                 680                 685             
Leu Val Glu Ala Leu Arg Thr His Pro Glu Met Val Phe Ala Arg Thr
    690                 695                 700                 
Ser Pro Gln Gln Lys Leu Val Ile Val Glu Ser Cys Gln Arg Leu Gly
705                 710                 715                 720 
Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu
                725                 730                 735     
Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Ala
            740                 745                 750         
Ala Lys Asn Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser
        755                 760                 765             
Ile Val Thr Gly Val Glu Gln Gly Arg Leu Ile Phe Asp Asn Leu Lys
    770                 775                 780                 
Lys Ser Ile Ala Tyr Thr Leu Thr Lys Asn Ile Pro Glu Leu Thr Pro
785                 790                 795                 800 
Tyr Leu Ile Tyr Ile Thr Val Ser Val Pro Leu Pro Leu Gly Cys Ile
                805                 810                 815     
Thr Ile Leu Phe Ile Glu Leu Cys Thr Asp Ile Phe Pro Ser Val Ser
            820                 825                 830         
Leu Ala Tyr Glu Lys Ala Glu Ser Asp Ile Met His Leu Arg Pro Arg
        835                 840                 845             
Asn Pro Lys Arg Asp Arg Leu Val Asn Glu Pro Leu Ala Ala Tyr Ser
    850                 855                 860                 
Tyr Phe Gln Ile Gly Ala Ile Gln Ser Phe Ala Gly Phe Thr Asp Tyr
865                 870                 875                 880 
Phe Thr Ala Met Ala Gln Glu Gly Trp Phe Pro Leu Leu Cys Val Gly
                885                 890                 895     
Leu Arg Ala Gln Trp Glu Asp His His Leu Gln Asp Leu Gln Asp Ser
            900                 905                 910         
Tyr Gly Gln Glu Trp Thr Phe Gly Gln Arg Leu Tyr Gln Gln Tyr Thr
        915                 920                 925             
Cys Tyr Thr Val Phe Phe Ile Ser Ile Glu Val Cys Gln Ile Ala Asp
    930                 935                 940                 
Val Leu Ile Arg Lys Thr Arg Arg Leu Ser Ala Phe Gln Gln Gly Phe
945                 950                 955                 960 
Phe Arg Asn Lys Ile Leu Val Ile Ala Ile Val Phe Gln Val Cys Ile
                965                 970                 975     
Gly Cys Phe Leu Cys Tyr Cys Pro Gly Met Pro Asn Ile Phe Asn Phe
            980                 985                 990         
Met Pro Ile Arg Phe Gln Trp Trp Leu Val Pro Leu Pro Tyr Gly Ile
        995                 1000                1005            
Leu Ile Phe Val Tyr Asp Glu Ile Arg Lys Leu Gly Val Arg Cys Cys
    1010                1015                1020                
Pro Gly Ser Trp Trp Asp Gln Glu Leu Tyr Tyr
1025                1030                1035


<210> 6614
<211> 1029
<212> PRT
<213> Homo sapiens

<400> 6614
Met Gly Leu Trp Gly Lys Lys Gly Thr Val Ala Pro His Asp Gln Ser
 1               5                  10                  15      
Pro Arg Arg Arg Pro Lys Lys Gly Leu Ile Lys Lys Lys Met Val Lys
            20                  25                  30          
Arg Glu Lys Gln Lys Arg Asn Met Glu Glu Leu Lys Lys Glu Val Val
        35                  40                  45              
Met Asp Asp His Lys Leu Thr Leu Glu Glu Leu Ser Thr Lys Tyr Ser
    50                  55                  60                  
Val Asp Leu Thr Lys Gly His Ser His Gln Arg Ala Lys Glu Ile Leu
65                  70                  75                  80  
Thr Arg Gly Gly Pro Asn Thr Val Thr Pro Pro Pro Thr Thr Pro Glu
                85                  90                  95      
Trp Val Lys Phe Cys Lys Gln Leu Phe Gly Gly Phe Ser Leu Leu Leu
            100                 105                 110         
Trp Thr Gly Ala Ile Leu Cys Phe Val Ala Tyr Ser Ile Gln Ile Tyr
        115                 120                 125             
Phe Asn Glu Glu Pro Thr Lys Asp Asn Leu Tyr Leu Ser Ile Val Leu
    130                 135                 140                 
Ser Val Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala
145                 150                 155                 160 
Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln
                165                 170                 175     
Ala Leu Val Ile Arg Gly Gly Glu Lys Met Gln Ile Asn Val Gln Glu
            180                 185                 190         
Val Val Leu Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro
        195                 200                 205             
Ala Asp Leu Arg Leu Ile Ser Ala Gln Gly Cys Lys Val Asp Asn Ser
    210                 215                 220                 
Ser Leu Thr Gly Glu Ser Glu Pro Gln Ser Arg Ser Pro Asp Phe Thr
225                 230                 235                 240 
His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe Ser Thr Asn
                245                 250                 255     
Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr Gly Asp Ser
            260                 265                 270         
Thr Val Met Gly Arg Ile Ala Ser Leu Thr Ser Gly Leu Ala Val Gly
        275                 280                 285             
Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His Leu Ile Thr
    290                 295                 300                 
Val Val Ala Val Phe Leu Gly Val Thr Phe Phe Ala Leu Ser Leu Leu
305                 310                 315                 320 
Leu Gly Tyr Gly Trp Leu Glu Ala Ile Ile Phe Leu Ile Gly Ile Ile
                325                 330                 335     
Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu
            340                 345                 350         
Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn
        355                 360                 365             
Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp
    370                 375                 380                 
Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp
385                 390                 395                 400 
Phe Asp Met Thr Val Tyr Glu Ala Asp Thr Thr Glu Glu Gln Thr Gly
                405                 410                 415     
Lys Thr Phe Thr Lys Ser Ser Asp Thr Trp Phe Met Leu Ala Arg Ile
            420                 425                 430         
Ala Gly Leu Cys Asn Arg Ala Asp Phe Lys Ala Asn Gln Glu Ile Leu
        435                 440                 445             
Pro Ile Ala Lys Arg Ala Thr Thr Gly Asp Ala Ser Glu Ser Ala Leu
    450                 455                 460                 
Leu Lys Phe Ile Glu Gln Ser Tyr Ser Ser Val Ala Glu Met Arg Glu
465                 470                 475                 480 
Lys Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr
                485                 490                 495     
Gln Met Ser Ile His Leu Arg Glu Asp Ser Ser Gln Thr His Val Leu
            500                 505                 510         
Met Met Lys Gly Ala Pro Glu Arg Ile Leu Glu Phe Cys Ser Thr Phe
        515                 520                 525             
Leu Leu Asn Gly Gln Glu Tyr Ser Met Asn Asp Glu Met Lys Glu Ala
    530                 535                 540                 
Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu
545                 550                 555                 560 
Gly Phe Cys Phe Leu Asn Leu Pro Ser Ser Phe Ser Lys Gly Phe Pro
                565                 570                 575     
Phe Asn Thr Asp Glu Ile Asn Phe Pro Met Asp Asn Leu Cys Phe Val
            580                 585                 590         
Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala
        595                 600                 605             
Val Ser Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly
    610                 615                 620                 
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile
625                 630                 635                 640 
Ser Glu Gly Thr Glu Thr Ala Glu Glu Val Ala Ala Arg Leu Lys Ile
                645                 650                 655     
Pro Ile Ser Lys Val Asp Ala Ser Ala Ala Lys Ala Ile Val Val His
            660                 665                 670         
Gly Ala Glu Leu Lys Asp Ile Gln Ser Lys Gln Leu Asp Gln Ile Leu
        675                 680                 685             
Gln Asn His Pro Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys
    690                 695                 700                 
Leu Ile Ile Val Glu Gly Cys Gln Arg Leu Gly Ala Val Val Ala Val
705                 710                 715                 720 
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile
                725                 730                 735     
Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys Gln Ala Ala
            740                 745                 750         
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val
        755                 760                 765             
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Met Tyr
    770                 775                 780                 
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Met Phe Ile
785                 790                 795                 800 
Ile Leu Gly Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile
                805                 810                 815     
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ser
            820                 825                 830         
Ala Glu Ser Asp Ile Met Lys Arg Leu Pro Arg Asn Pro Lys Thr Asp
        835                 840                 845             
Asn Leu Val Asn His Arg Leu Ile Gly Met Ala Tyr Gly Gln Ile Gly
    850                 855                 860                 
Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala
865                 870                 875                 880 
Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg Leu His Trp
                885                 890                 895     
Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp
            900                 905                 910         
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln Thr Ala Phe
        915                 920                 925             
Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Ser Lys
    930                 935                 940                 
Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn Lys Val Leu
945                 950                 955                 960 
Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe Leu Ser Tyr
                965                 970                 975     
Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Ile Thr
            980                 985                 990         
Trp Trp Leu Cys Ala Ile Pro Tyr Ser Ile Leu Ile Phe Val Tyr Asp
        995                 1000                1005            
Glu Ile Arg Lys Leu Leu Ile Arg Gln His Pro Asp Gly Trp Val Glu
    1010                1015                1020                
Arg Glu Thr Tyr Tyr
1025                


<210> 6615
<211> 1023
<212> PRT
<213> Homo sapiens

<400> 6615
Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser
 1               5                  10                  15      
Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met
            20                  25                  30          
Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu
        35                  40                  45              
Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr
    50                  55                  60                  
Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu
65                  70                  75                  80  
Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu
                85                  90                  95      
Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe
            100                 105                 110         
Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp
        115                 120                 125             
Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly
    130                 135                 140                 
Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser
145                 150                 155                 160 
Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu
                165                 170                 175     
Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu
            180                 185                 190         
Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala
        195                 200                 205             
Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro
    210                 215                 220                 
Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg
225                 230                 235                 240 
Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly
                245                 250                 255     
Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr
            260                 265                 270         
Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile
        275                 280                 285             
Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val
    290                 295                 300                 
Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala
305                 310                 315                 320 
Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu
                325                 330                 335     
Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala
            340                 345                 350         
Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly
        355                 360                 365             
Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn
    370                 375                 380                 
Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala
385                 390                 395                 400 
Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala
                405                 410                 415     
Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val
            420                 425                 430         
Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala
        435                 440                 445             
Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys
    450                 455                 460                 
Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile
465                 470                 475                 480 
Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro
                485                 490                 495     
Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu
            500                 505                 510         
Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln
        515                 520                 525             
Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu
    530                 535                 540                 
Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu
545                 550                 555                 560 
Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val
                565                 570                 575     
Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile
            580                 585                 590         
Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser
        595                 600                 605             
Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala
    610                 615                 620                 
Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr
625                 630                 635                 640 
Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn
                645                 650                 655     
Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp
            660                 665                 670         
Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile
        675                 680                 685             
Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly
    690                 695                 700                 
Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn
705                 710                 715                 720 
Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile
                725                 730                 735     
Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp
            740                 745                 750         
Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile
        755                 760                 765             
Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile
    770                 775                 780                 
Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu
785                 790                 795                 800 
Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met
                805                 810                 815     
Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met
            820                 825                 830         
Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg
        835                 840                 845             
Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly
    850                 855                 860                 
Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro
865                 870                 875                 880 
Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn
                885                 890                 895     
Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys
            900                 905                 910         
Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val
        915                 920                 925             
Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val
    930                 935                 940                 
Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu
945                 950                 955                 960 
Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val
                965                 970                 975     
Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe
            980                 985                 990         
Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu Ile
        995                 1000                1005            
Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr
    1010                1015                1020            


<210> 6616
<211> 1000
<212> PRT
<213> Homo sapiens

<400> 6616
Met Val Lys Arg Glu Lys Gln Lys Arg Asn Met Glu Glu Leu Lys Lys
 1               5                  10                  15      
Glu Val Val Met Asp Asp His Lys Leu Thr Leu Glu Glu Leu Ser Thr
            20                  25                  30          
Lys Tyr Ser Val Asp Leu Thr Lys Gly His Ser His Gln Arg Ala Lys
        35                  40                  45              
Glu Ile Leu Thr Arg Gly Gly Pro Asn Thr Val Thr Pro Pro Pro Thr
    50                  55                  60                  
Thr Pro Glu Trp Val Lys Phe Cys Lys Gln Leu Phe Gly Gly Phe Ser
65                  70                  75                  80  
Leu Leu Leu Trp Thr Gly Ala Ile Leu Cys Phe Val Ala Tyr Ser Ile
                85                  90                  95      
Gln Ile Tyr Phe Asn Glu Glu Pro Thr Lys Asp Asn Leu Tyr Leu Ser
            100                 105                 110         
Ile Val Leu Ser Val Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr
        115                 120                 125             
Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val
    130                 135                 140                 
Pro Gln Gln Ala Leu Val Ile Arg Gly Gly Glu Lys Met Gln Ile Asn
145                 150                 155                 160 
Val Gln Glu Val Val Leu Gly Asp Leu Val Glu Ile Lys Gly Gly Asp
                165                 170                 175     
Arg Val Pro Ala Asp Leu Arg Leu Ile Ser Ala Gln Gly Cys Lys Val
            180                 185                 190         
Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Ser Arg Ser Pro
        195                 200                 205             
Asp Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe
    210                 215                 220                 
Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr
225                 230                 235                 240 
Gly Asp Ser Thr Val Met Gly Arg Ile Ala Ser Leu Thr Ser Gly Leu
                245                 250                 255     
Ala Val Gly Gln Thr Pro Ile Ala Ala Glu Ile Glu His Phe Ile His
            260                 265                 270         
Leu Ile Thr Val Val Ala Val Phe Leu Gly Val Thr Phe Phe Ala Leu
        275                 280                 285             
Ser Leu Leu Leu Gly Tyr Gly Trp Leu Glu Ala Ile Ile Phe Leu Ile
    290                 295                 300                 
Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr
305                 310                 315                 320 
Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu
                325                 330                 335     
Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile
            340                 345                 350         
Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala
        355                 360                 365             
His Met Trp Phe Asp Met Thr Val Tyr Glu Ala Asp Thr Thr Glu Glu
    370                 375                 380                 
Gln Thr Gly Lys Thr Phe Thr Lys Ser Ser Asp Thr Trp Phe Met Leu
385                 390                 395                 400 
Ala Arg Ile Ala Gly Leu Cys Asn Arg Ala Asp Phe Lys Ala Asn Gln
                405                 410                 415     
Glu Ile Leu Pro Ile Ala Lys Arg Ala Thr Thr Gly Asp Ala Ser Glu
            420                 425                 430         
Ser Ala Leu Leu Lys Phe Ile Glu Gln Ser Tyr Ser Ser Val Ala Glu
        435                 440                 445             
Met Arg Glu Lys Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr
    450                 455                 460                 
Asn Lys Tyr Gln Met Ser Ile His Leu Arg Glu Asp Ser Ser Gln Thr
465                 470                 475                 480 
His Val Leu Met Met Lys Gly Ala Pro Glu Arg Ile Leu Glu Phe Cys
                485                 490                 495     
Ser Thr Phe Leu Leu Asn Gly Gln Glu Tyr Ser Met Asn Asp Glu Met
            500                 505                 510         
Lys Glu Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu
        515                 520                 525             
Arg Val Leu Gly Phe Cys Phe Leu Asn Leu Pro Ser Ser Phe Ser Lys
    530                 535                 540                 
Gly Phe Pro Phe Asn Thr Asp Glu Ile Asn Phe Pro Met Asp Asn Leu
545                 550                 555                 560 
Cys Phe Val Gly Leu Ile Ser Met Ile Asp Pro Pro Arg Ala Ala Val
                565                 570                 575     
Pro Asp Ala Val Ser Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met
            580                 585                 590         
Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val
        595                 600                 605             
Gly Ile Ile Ser Glu Gly Thr Glu Thr Ala Glu Glu Val Ala Ala Arg
    610                 615                 620                 
Leu Lys Ile Pro Ile Ser Lys Val Asp Ala Ser Ala Ala Lys Ala Ile
625                 630                 635                 640 
Val Val His Gly Ala Glu Leu Lys Asp Ile Gln Ser Lys Gln Leu Asp
                645                 650                 655     
Gln Ile Leu Gln Asn His Pro Glu Ile Val Phe Ala Arg Thr Ser Pro
            660                 665                 670         
Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Leu Gly Ala Val
        675                 680                 685             
Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys
    690                 695                 700                 
Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys
705                 710                 715                 720 
Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val
                725                 730                 735     
Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser
            740                 745                 750         
Ile Met Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu
        755                 760                 765             
Met Phe Ile Ile Leu Gly Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile
    770                 775                 780                 
Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala
785                 790                 795                 800 
Tyr Glu Ser Ala Glu Ser Asp Ile Met Lys Arg Leu Pro Arg Asn Pro
                805                 810                 815     
Lys Thr Asp Asn Leu Val Asn His Arg Leu Ile Gly Met Ala Tyr Gly
            820                 825                 830         
Gln Ile Gly Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val
        835                 840                 845             
Ile Leu Ala Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg
    850                 855                 860                 
Leu His Trp Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly
865                 870                 875                 880 
Gln Gln Trp Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln
                885                 890                 895     
Thr Ala Phe Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile
            900                 905                 910         
Ile Ser Lys Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn
        915                 920                 925             
Lys Val Leu Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe
    930                 935                 940                 
Leu Ser Tyr Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu
945                 950                 955                 960 
Lys Ile Thr Trp Trp Leu Cys Ala Ile Pro Tyr Ser Ile Leu Ile Phe
                965                 970                 975     
Val Tyr Asp Glu Ile Arg Lys Leu Leu Ile Arg Gln His Pro Asp Gly
            980                 985                 990         
Trp Val Glu Arg Glu Thr Tyr Tyr
        995                 1000


<210> 6617
<211> 1020
<212> PRT
<213> Homo sapiens

<400> 6617
Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala
 1               5                  10                  15      
Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu
            20                  25                  30          
Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu
        35                  40                  45              
Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln
    50                  55                  60                  
Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro
65                  70                  75                  80  
Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly
                85                  90                  95      
Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala
            100                 105                 110         
Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu
        115                 120                 125             
Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe
    130                 135                 140                 
Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys
145                 150                 155                 160 
Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met
                165                 170                 175     
Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys
            180                 185                 190         
Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly
        195                 200                 205             
Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr
    210                 215                 220                 
Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile
225                 230                 235                 240 
Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val
                245                 250                 255     
Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala
            260                 265                 270         
Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His
        275                 280                 285             
Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe
    290                 295                 300                 
Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile
305                 310                 315                 320 
Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala
                325                 330                 335     
Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys
            340                 345                 350         
Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr
        355                 360                 365             
Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met
    370                 375                 380                 
Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr
385                 390                 395                 400 
Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp
                405                 410                 415     
Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys
            420                 425                 430         
Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp
        435                 440                 445             
Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser
    450                 455                 460                 
Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe
465                 470                 475                 480 
Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser
                485                 490                 495     
Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu
            500                 505                 510         
Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp
        515                 520                 525             
Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly
    530                 535                 540                 
Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly
545                 550                 555                 560 
Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro
                565                 570                 575     
Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro
            580                 585                 590         
Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile
        595                 600                 605             
Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile
    610                 615                 620                 
Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp
625                 630                 635                 640 
Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu
                645                 650                 655     
Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser
            660                 665                 670         
Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala
        675                 680                 685             
Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg
    690                 695                 700                 
Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro
705                 710                 715                 720 
Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser
                725                 730                 735     
Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe
            740                 745                 750         
Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn
        755                 760                 765             
Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile
    770                 775                 780                 
Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly
785                 790                 795                 800 
Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala
                805                 810                 815     
Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln
            820                 825                 830         
Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser
        835                 840                 845             
Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe
    850                 855                 860                 
Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu
865                 870                 875                 880 
Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu
                885                 890                 895     
Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu
            900                 905                 910         
Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp
        915                 920                 925             
Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln
    930                 935                 940                 
Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala
945                 950                 955                 960 
Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg
                965                 970                 975     
Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser
            980                 985                 990         
Leu Leu Ile Phe Ile Tyr Asp Glu Val Arg Lys Leu Ile Leu Arg Arg
        995                 1000                1005            
Tyr Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr
    1010                1015                1020


<210> 6618
<211> 545
<212> PRT
<213> Homo sapiens

<400> 6618
Met Gly Asn Thr Pro Gln Lys Lys Ala Val Phe Gly Gln Cys Arg Gly
 1               5                  10                  15      
Leu Pro Cys Val Ala Pro Leu Leu Thr Thr Val Glu Glu Ala Pro Arg
            20                  25                  30          
Gly Ile Ser Ala Arg Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly
        35                  40                  45              
Ser Leu Leu Arg Ile Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys
    50                  55                  60                  
Tyr Asn His Trp Phe Asp Gly Met Ala Leu Leu His Gln Phe Arg Met
65                  70                  75                  80  
Ala Lys Gly Thr Val Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr
                85                  90                  95      
Tyr Lys Ala Asn Ser Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly
            100                 105                 110         
Thr Leu Ala Leu Pro Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met
        115                 120                 125             
Ser Arg Phe Glu Leu Pro Gly Lys Ala Ala Ala Met Thr Asp Asn Thr
    130                 135                 140                 
Asn Val Asn Tyr Val Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys Thr Glu
145                 150                 155                 160 
Thr Asn Phe Met Asn Lys Val Asp Ile Glu Thr Leu Glu Lys Thr Glu
                165                 170                 175     
Lys Val Asp Trp Ser Lys Phe Ile Ala Val Asn Gly Ala Thr Ala His
            180                 185                 190         
Pro His Tyr Asp Pro Asp Gly Thr Ala Tyr Asn Met Gly Asn Ser Phe
        195                 200                 205             
Gly Pro Tyr Gly Phe Ser Tyr Lys Val Ile Arg Val Pro Pro Glu Lys
    210                 215                 220                 
Val Asp Leu Gly Glu Thr Ile His Gly Val Gln Val Ile Cys Ser Ile
225                 230                 235                 240 
Ala Ser Thr Glu Lys Gly Lys Pro Ser Tyr Tyr His Ser Phe Gly Met
                245                 250                 255     
Thr Arg Asn Tyr Ile Ile Phe Ile Glu Gln Pro Leu Lys Met Asn Leu
            260                 265                 270         
Trp Lys Ile Ala Thr Ser Lys Ile Arg Gly Lys Ala Phe Ser Asp Gly
        275                 280                 285             
Ile Ser Trp Glu Pro Gln Cys Asn Thr Arg Phe His Val Val Glu Lys
    290                 295                 300                 
Arg Thr Gly Gln Leu Leu Pro Gly Arg Tyr Tyr Ser Lys Pro Phe Val
305                 310                 315                 320 
Thr Phe His Gln Ile Asn Ala Phe Glu Asp Gln Gly Cys Val Ile Ile
                325                 330                 335     
Asp Leu Cys Cys Gln Asp Asn Gly Arg Thr Leu Glu Val Tyr Gln Leu
            340                 345                 350         
Gln Asn Leu Arg Lys Ala Gly Glu Gly Leu Asp Gln Val His Asn Ser
        355                 360                 365             
Ala Ala Lys Ser Phe Pro Arg Arg Phe Val Leu Pro Leu Asn Val Ser
    370                 375                 380                 
Leu Asn Ala Pro Glu Gly Asp Asn Leu Ser Pro Leu Ser Tyr Thr Ser
385                 390                 395                 400 
Ala Ser Ala Val Lys Gln Ala Asp Gly Thr Ile Trp Cys Ser His Glu
                405                 410                 415     
Asn Leu His Gln Glu Asp Leu Glu Lys Glu Gly Gly Ile Glu Phe Pro
            420                 425                 430         
Gln Ile Tyr Tyr Asp Arg Phe Ser Gly Lys Lys Tyr His Phe Phe Tyr
        435                 440                 445             
Gly Cys Gly Phe Arg His Leu Val Gly Asp Ser Leu Ile Lys Val Asp
    450                 455                 460                 
Val Val Asn Lys Thr Leu Lys Val Trp Arg Glu Asp Gly Phe Tyr Pro
465                 470                 475                 480 
Ser Glu Pro Val Phe Val Pro Ala Pro Gly Thr Asn Glu Glu Asp Gly
                485                 490                 495     
Gly Val Ile Leu Ser Val Val Ile Thr Pro Asn Gln Asn Glu Ser Asn
            500                 505                 510         
Phe Leu Leu Val Leu Asp Ala Lys Asn Phe Glu Glu Leu Gly Arg Ala
        515                 520                 525             
Glu Val Pro Val Gln Met Pro Tyr Gly Phe His Gly Thr Phe Ile Pro
    530                 535                 540                 
Ile
545 


<210> 6619
<211> 534
<212> PRT
<213> Homo sapiens

<400> 6619
Phe Cys Ala Cys Ser Leu Phe Ser Ser Thr Gln Asn Cys Gln Cys Glu
 1               5                  10                  15      
Arg Ile Trp Lys Ser Leu Asp Leu Leu Asn Thr Lys Met Phe Phe Arg
            20                  25                  30          
Val Phe Leu His Phe Ile Arg Ser His Ser Ala Thr Ala Val Asp Phe
        35                  40                  45              
Leu Pro Val Met Val His Arg Leu Pro Val Phe Lys Arg Tyr Met Gly
    50                  55                  60                  
Asn Thr Pro Gln Lys Lys Ala Val Phe Gly Gln Cys Arg Gly Leu Pro
65                  70                  75                  80  
Cys Val Ala Pro Leu Leu Thr Thr Val Glu Glu Ala Pro Arg Gly Ile
                85                  90                  95      
Ser Ala Arg Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly Ser Leu
            100                 105                 110         
Leu Arg Ile Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys Tyr Asn
        115                 120                 125             
His Trp Phe Asp Gly Met Ala Leu Leu His Gln Phe Arg Met Ala Lys
    130                 135                 140                 
Gly Thr Val Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr Tyr Lys
145                 150                 155                 160 
Ala Asn Ser Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly Thr Leu
                165                 170                 175     
Ala Leu Pro Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met Ser Arg
            180                 185                 190         
Phe Glu Leu Pro Gly Lys Ala Ala Gly Phe Ser Tyr Lys Val Ile Arg
        195                 200                 205             
Val Pro Pro Glu Lys Val Asp Leu Gly Glu Thr Ile His Gly Val Gln
    210                 215                 220                 
Val Ile Cys Ser Ile Ala Ser Thr Glu Lys Gly Lys Pro Ser Tyr Tyr
225                 230                 235                 240 
His Ser Phe Gly Met Thr Arg Asn Tyr Ile Ile Phe Ile Glu Gln Pro
                245                 250                 255     
Leu Lys Met Asn Leu Trp Lys Ile Ala Thr Ser Lys Ile Arg Gly Lys
            260                 265                 270         
Ala Phe Ser Asp Gly Ile Ser Trp Glu Pro Gln Cys Asn Thr Arg Phe
        275                 280                 285             
His Val Val Glu Lys Arg Thr Gly Gln Leu Leu Pro Gly Arg Tyr Tyr
    290                 295                 300                 
Ser Lys Pro Phe Val Thr Phe His Gln Ile Asn Ala Phe Glu Asp Gln
305                 310                 315                 320 
Gly Cys Val Ile Ile Asp Leu Cys Cys Gln Asp Asn Gly Arg Thr Leu
                325                 330                 335     
Glu Val Tyr Gln Leu Gln Asn Leu Arg Lys Ala Gly Glu Gly Leu Asp
            340                 345                 350         
Gln Val His Asn Ser Ala Ala Lys Ser Phe Pro Arg Arg Phe Val Leu
        355                 360                 365             
Pro Leu Asn Val Ser Leu Asn Ala Pro Glu Gly Asp Asn Leu Ser Pro
    370                 375                 380                 
Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys Gln Ala Asp Gly Thr Ile
385                 390                 395                 400 
Trp Cys Ser His Glu Asn Leu His Gln Glu Asp Leu Glu Lys Glu Gly
                405                 410                 415     
Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp Arg Phe Ser Gly Lys Lys
            420                 425                 430         
Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg His Leu Val Gly Asp Ser
        435                 440                 445             
Leu Ile Lys Val Asp Val Val Asn Lys Thr Leu Lys Val Trp Arg Glu
    450                 455                 460                 
Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val Pro Ala Pro Gly Thr
465                 470                 475                 480 
Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val Val Ile Thr Pro Asn
                485                 490                 495     
Gln Asn Glu Ser Asn Phe Ile Leu Val Leu Asp Ala Lys Asn Phe Glu
            500                 505                 510         
Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met Pro Tyr Gly Phe His
        515                 520                 525             
Gly Thr Phe Ile Pro Ile
    530                 


<210> 6620
<211> 539
<212> PRT
<213> Homo sapiens

<400> 6620
Met Gly Asn Thr Pro Gln Lys Lys Ala Val Phe Gly Gln Cys Arg Gly
 1               5                  10                  15      
Leu Pro Cys Val Ala Pro Leu Leu Thr Thr Val Glu Glu Ala Pro Arg
            20                  25                  30          
Gly Ile Ser Ala Arg Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly
        35                  40                  45              
Ser Leu Leu Arg Ile Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys
    50                  55                  60                  
Tyr Asn His Trp Phe Asp Gly Met Ala Leu Leu His Gln Phe Arg Met
65                  70                  75                  80  
Ala Lys Gly Thr Val Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr
                85                  90                  95      
Tyr Lys Ala Asn Ser Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly
            100                 105                 110         
Thr Leu Ala Leu Pro Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met
        115                 120                 125             
Ser Arg Phe Glu Leu Pro Gly Lys Ala Ala Ala Met Thr Asp Asn Thr
    130                 135                 140                 
Asn Val Asn Tyr Val Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys Thr Glu
145                 150                 155                 160 
Thr Asn Phe Met Asn Lys Val Asp Ile Glu Thr Leu Glu Lys Thr Glu
                165                 170                 175     
Lys Val Asp Trp Ser Lys Phe Ile Ala Val Asn Gly Ala Thr Ala His
            180                 185                 190         
Pro His Tyr Asp Pro Asp Gly Thr Ala Tyr Asn Met Gly Asn Ser Phe
        195                 200                 205             
Gly Pro Tyr Gly Phe Ser Tyr Lys Val Ile Arg Val Pro Pro Glu Lys
    210                 215                 220                 
Val Asp Leu Gly Glu Thr Ile His Gly Val Gln Val Ile Cys Ser Ile
225                 230                 235                 240 
Ala Ser Thr Glu Lys Gly Lys Pro Ser Tyr Tyr His Ser Phe Gly Met
                245                 250                 255     
Thr Arg Asn Tyr Ile Ile Phe Ile Glu Gln Pro Leu Lys Met Asn Leu
            260                 265                 270         
Trp Lys Ile Ala Thr Ser Lys Ile Arg Gly Lys Ala Phe Ser Asp Gly
        275                 280                 285             
Ile Ser Trp Glu Pro Gln Cys Asn Thr Arg Phe His Val Val Glu Lys
    290                 295                 300                 
Arg Thr Gly Gln Leu Leu Pro Gly Arg Tyr Tyr Ser Lys Pro Phe Val
305                 310                 315                 320 
Thr Phe His Gln Ile Asn Ala Phe Glu Asp Gln Gly Cys Val Ile Ile
                325                 330                 335     
Asp Leu Cys Cys Gln Asp Asn Gly Arg Thr Leu Glu Val Tyr Gln Leu
            340                 345                 350         
Gln Asn Leu Arg Lys Ala Gly Glu Gly Leu Asp Gln Val His Asn Ser
        355                 360                 365             
Ala Ala Lys Ser Phe Pro Arg Arg Phe Val Leu Pro Leu Asn Val Ser
    370                 375                 380                 
Leu Asn Ala Pro Glu Gly Asp Asn Leu Ser Pro Leu Ser Tyr Thr Ser
385                 390                 395                 400 
Ala Ser Ala Val Lys Gln Ala Asp Gly Thr Ile Trp Cys Ser His Glu
                405                 410                 415     
Asn Leu His Gln Glu Asp Leu Glu Lys Glu Gly Gly Ile Glu Phe Pro
            420                 425                 430         
Gln Ile Tyr Tyr Asp Arg Phe Ser Gly Lys Lys Tyr His Phe Phe Tyr
        435                 440                 445             
Gly Cys Gly Phe Arg His Leu Val Gly Asp Ser Leu Ile Lys Val Asp
    450                 455                 460                 
Val Val Trp Arg Glu Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val
465                 470                 475                 480 
Pro Ala Pro Gly Thr Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val
                485                 490                 495     
Val Ile Thr Pro Asn Gln Asn Glu Ser Asn Phe Leu Leu Val Leu Asp
            500                 505                 510         
Ala Lys Asn Phe Glu Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met
        515                 520                 525             
Pro Tyr Gly Phe His Gly Thr Phe Ile Pro Ile
    530                 535                 


<210> 6621
<211> 550
<212> PRT
<213> Homo sapiens

<400> 6621
Met Val Tyr Arg Leu Pro Val Phe Lys Arg Tyr Met Gly Asn Thr Pro
 1               5                  10                  15      
Gln Lys Lys Ala Val Phe Gly Gln Cys Arg Gly Leu Pro Cys Val Ala
            20                  25                  30          
Pro Leu Leu Thr Thr Val Glu Glu Ala Pro Arg Gly Ile Ser Ala Arg
        35                  40                  45              
Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly Ser Leu Leu Arg Ile
    50                  55                  60                  
Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys Tyr Asn His Trp Phe
65                  70                  75                  80  
Asp Gly Met Ala Leu Leu His Gln Phe Arg Met Ala Lys Gly Thr Val
                85                  90                  95      
Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr Tyr Lys Ala Asn Ser
            100                 105                 110         
Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly Thr Leu Ala Leu Pro
        115                 120                 125             
Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met Ser Arg Phe Glu Leu
    130                 135                 140                 
Pro Gly Lys Ala Ala Ala Met Thr Asp Asn Thr Asn Val Asn Tyr Val
145                 150                 155                 160 
Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys Thr Glu Thr Asn Phe Met Asn
                165                 170                 175     
Lys Val Asp Ile Glu Thr Leu Glu Lys Thr Glu Lys Val Asp Trp Ser
            180                 185                 190         
Lys Phe Ile Ala Val Asn Gly Ala Thr Ala His Pro His Tyr Asp Pro
        195                 200                 205             
Asp Gly Thr Ala Tyr Asn Met Gly Asn Ser Phe Gly Pro Tyr Gly Phe
    210                 215                 220                 
Ser Tyr Lys Val Ile Arg Val Pro Pro Glu Lys Val Asp Leu Gly Glu
225                 230                 235                 240 
Thr Ile His Gly Val Gln Val Ile Cys Ser Ile Ala Ser Thr Glu Lys
                245                 250                 255     
Gly Lys Pro Ser Tyr Tyr His Ser Phe Gly Met Thr Arg Asn Tyr Ile
            260                 265                 270         
Ile Phe Ile Glu Gln Pro Leu Lys Met Asn Leu Trp Lys Ile Ala Thr
        275                 280                 285             
Ser Lys Ile Arg Gly Lys Ala Phe Ser Asp Gly Ile Ser Trp Glu Pro
    290                 295                 300                 
Gln Cys Asn Thr Arg Phe His Val Val Glu Lys Arg Thr Gly Gln Leu
305                 310                 315                 320 
Leu Pro Gly Arg Tyr Tyr Ser Lys Pro Phe Val Thr Phe His Gln Ile
                325                 330                 335     
Asn Ala Phe Glu Asp Gln Gly Cys Val Ile Ile Asp Leu Cys Cys Gln
            340                 345                 350         
Asp Asn Gly Arg Thr Leu Glu Val Tyr Gln Leu Gln Asn Leu Arg Lys
        355                 360                 365             
Ala Gly Glu Gly Leu Asp Gln Val His Asn Ser Ala Ala Lys Ser Phe
    370                 375                 380                 
Pro Arg Arg Phe Val Leu Pro Leu Asn Val Ser Leu Asn Ala Pro Glu
385                 390                 395                 400 
Gly Asp Asn Leu Ser Pro Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys
                405                 410                 415     
Gln Ala Asp Gly Thr Ile Trp Cys Ser His Glu Asn Leu His Gln Glu
            420                 425                 430         
Asp Leu Glu Lys Glu Gly Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp
        435                 440                 445             
Arg Phe Ser Gly Lys Lys Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg
    450                 455                 460                 
His Leu Val Gly Asp Ser Leu Ile Lys Val Asp Val Val Trp Arg Glu
465                 470                 475                 480 
Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val Pro Ala Pro Gly Thr
                485                 490                 495     
Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val Val Ile Thr Pro Asn
            500                 505                 510         
Gln Asn Glu Ser Asn Phe Leu Leu Val Leu Asp Ala Lys Asn Phe Glu
        515                 520                 525             
Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met Pro Tyr Gly Phe His
    530                 535                 540                 
Gly Thr Phe Ile Pro Ile
545                 550 


<210> 6622
<211> 556
<212> PRT
<213> Homo sapiens

<400> 6622
Met Val Tyr Arg Leu Pro Val Phe Lys Arg Tyr Met Gly Asn Thr Pro
 1               5                  10                  15      
Gln Lys Lys Ala Val Phe Gly Gln Cys Arg Gly Leu Pro Cys Val Ala
            20                  25                  30          
Pro Leu Leu Thr Thr Val Glu Glu Ala Pro Arg Gly Ile Ser Ala Arg
        35                  40                  45              
Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly Ser Leu Leu Arg Ile
    50                  55                  60                  
Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys Tyr Asn His Trp Phe
65                  70                  75                  80  
Asp Gly Met Ala Leu Leu His Gln Phe Arg Met Ala Lys Gly Thr Val
                85                  90                  95      
Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr Tyr Lys Ala Asn Ser
            100                 105                 110         
Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly Thr Leu Ala Leu Pro
        115                 120                 125             
Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met Ser Arg Phe Glu Leu
    130                 135                 140                 
Pro Gly Lys Ala Ala Ala Met Thr Asp Asn Thr Asn Val Asn Tyr Val
145                 150                 155                 160 
Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys Thr Glu Thr Asn Phe Met Asn
                165                 170                 175     
Lys Val Asp Ile Glu Thr Leu Glu Lys Thr Glu Lys Val Asp Trp Ser
            180                 185                 190         
Lys Phe Ile Ala Val Asn Gly Ala Thr Ala His Pro His Tyr Asp Pro
        195                 200                 205             
Asp Gly Thr Ala Tyr Asn Met Gly Asn Ser Phe Gly Pro Tyr Gly Phe
    210                 215                 220                 
Ser Tyr Lys Val Ile Arg Val Pro Pro Glu Lys Val Asp Leu Gly Glu
225                 230                 235                 240 
Thr Ile His Gly Val Gln Val Ile Cys Ser Ile Ala Ser Thr Glu Lys
                245                 250                 255     
Gly Lys Pro Ser Tyr Tyr His Ser Phe Gly Met Thr Arg Asn Tyr Ile
            260                 265                 270         
Ile Phe Ile Glu Gln Pro Leu Lys Met Asn Leu Trp Lys Ile Ala Thr
        275                 280                 285             
Ser Lys Ile Arg Gly Lys Ala Phe Ser Asp Gly Ile Ser Trp Glu Pro
    290                 295                 300                 
Gln Cys Asn Thr Arg Phe His Val Val Glu Lys Arg Thr Gly Gln Leu
305                 310                 315                 320 
Leu Pro Gly Arg Tyr Tyr Ser Lys Pro Phe Val Thr Phe His Gln Ile
                325                 330                 335     
Asn Ala Phe Glu Asp Gln Gly Cys Val Ile Ile Asp Leu Cys Cys Gln
            340                 345                 350         
Asp Asn Gly Arg Thr Leu Glu Val Tyr Gln Leu Gln Asn Leu Arg Lys
        355                 360                 365             
Ala Gly Glu Gly Leu Asp Gln Val His Asn Ser Ala Ala Lys Ser Phe
    370                 375                 380                 
Pro Arg Arg Phe Val Leu Pro Leu Asn Val Ser Leu Asn Ala Pro Glu
385                 390                 395                 400 
Gly Asp Asn Leu Ser Pro Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys
                405                 410                 415     
Gln Ala Asp Gly Thr Ile Trp Cys Ser His Glu Asn Leu His Gln Glu
            420                 425                 430         
Asp Leu Glu Lys Glu Gly Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp
        435                 440                 445             
Arg Phe Ser Gly Lys Lys Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg
    450                 455                 460                 
His Leu Val Gly Asp Ser Leu Ile Lys Val Asp Val Val Asn Lys Thr
465                 470                 475                 480 
Leu Lys Val Trp Arg Glu Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe
                485                 490                 495     
Val Pro Ala Pro Gly Thr Asn Glu Glu Asp Gly Gly Val Ile Leu Ser
            500                 505                 510         
Val Val Ile Thr Pro Asn Gln Asn Glu Ser Asn Phe Leu Leu Val Leu
        515                 520                 525             
Asp Ala Lys Asn Phe Glu Glu Leu Gly Arg Ala Glu Val Pro Val Gln
    530                 535                 540                 
Met Pro Tyr Gly Phe His Gly Thr Phe Ile Pro Ile
545                 550                 555     


<210> 6623
<211> 869
<212> PRT
<213> Homo sapiens

<400> 6623
Ser Glu Ser Ala Val Val Val Gln Thr Glu Cys Ser Leu Leu Phe Val
 1               5                  10                  15      
Trp Leu Arg Phe His Ala Arg Arg Trp Leu Arg Met Ser Ser Ser His
            20                  25                  30          
Phe Ala Ser Arg His Arg Lys Asp Ile Ser Thr Glu Met Ile Arg Thr
        35                  40                  45              
Lys Ile Ala His Arg Lys Ser Leu Ser Gln Lys Glu Asn Arg His Lys
    50                  55                  60                  
Glu Tyr Glu Arg Asn Arg His Phe Gly Leu Lys Asp Val Asn Ile Pro
65                  70                  75                  80  
Thr Leu Glu Gly Arg Ile Leu Val Glu Leu Asp Glu Thr Ser Gln Gly
                85                  90                  95      
Leu Val Pro Glu Lys Thr Asn Val Lys Pro Arg Ala Met Lys Thr Ile
            100                 105                 110         
Leu Gly Asp Gln Arg Lys Gln Met Leu Gln Lys Tyr Lys Glu Glu Lys
        115                 120                 125             
Gln Leu Gln Lys Leu Lys Glu Gln Arg Glu Lys Ala Lys Arg Gly Ile
    130                 135                 140                 
Phe Lys Val Gly Arg Tyr Arg Pro Asp Met Pro Cys Phe Leu Leu Ser
145                 150                 155                 160 
Asn Gln Asn Ala Val Lys Ala Glu Pro Lys Lys Ala Ile Pro Ser Ser
                165                 170                 175     
Val Arg Ile Thr Arg Ser Lys Ala Lys Asp Gln Met Glu Gln Thr Lys
            180                 185                 190         
Ile Asp Asn Glu Ser Asp Val Arg Ala Ile Arg Pro Gly Pro Arg Gln
        195                 200                 205             
Thr Ser Glu Lys Lys Val Ser Asp Lys Glu Lys Lys Val Val Gln Pro
    210                 215                 220                 
Val Met Pro Thr Ser Leu Arg Met Thr Arg Ser Ala Thr Gln Ala Ala
225                 230                 235                 240 
Lys Gln Val Pro Arg Thr Val Ser Ser Thr Thr Ala Arg Lys Pro Val
                245                 250                 255     
Thr Arg Ala Ala Asn Glu Asn Glu Pro Glu Gly Lys Val Pro Ser Lys
            260                 265                 270         
Gly Arg Pro Ala Lys Asn Val Glu Thr Lys Pro Asp Lys Gly Ile Ser
        275                 280                 285             
Cys Lys Val Asp Ser Glu Glu Asn Thr Leu Asn Ser Gln Thr Asn Ala
    290                 295                 300                 
Thr Ser Gly Met Asn Pro Asp Gly Val Leu Ser Lys Met Glu Asn Leu
305                 310                 315                 320 
Pro Glu Ile Asn Thr Ala Lys Ile Lys Gly Lys Asn Ser Phe Ala Pro
                325                 330                 335     
Lys Asp Phe Met Phe Gln Pro Leu Asp Gly Leu Lys Thr Tyr Gln Val
            340                 345                 350         
Thr Pro Met Thr Pro Arg Ser Ala Asn Ala Phe Leu Thr Pro Ser Tyr
        355                 360                 365             
Thr Trp Thr Pro Leu Lys Thr Glu Val Asp Glu Ser Gln Ala Thr Lys
    370                 375                 380                 
Glu Ile Leu Ala Gln Lys Cys Lys Thr Tyr Ser Thr Lys Thr Ile Gln
385                 390                 395                 400 
Gln Asp Ser Asn Lys Leu Pro Cys Pro Leu Gly Pro Leu Thr Val Trp
                405                 410                 415     
His Glu Glu His Val Leu Asn Lys Asn Glu Ala Thr Thr Lys Asn Leu
            420                 425                 430         
Asn Gly Leu Pro Ile Lys Glu Val Pro Ser Leu Glu Arg Asn Glu Gly
        435                 440                 445             
Arg Ile Ala Gln Pro His His Gly Val Pro Tyr Phe Arg Asn Ile Leu
    450                 455                 460                 
Gln Ser Glu Thr Glu Lys Leu Thr Ser His Cys Phe Glu Trp Asp Arg
465                 470                 475                 480 
Lys Leu Glu Leu Asp Ile Pro Asp Asp Ala Lys Asp Leu Ile Arg Thr
                485                 490                 495     
Ala Val Gly Gln Thr Arg Leu Leu Met Lys Glu Arg Phe Lys Gln Phe
            500                 505                 510         
Glu Gly Leu Val Asp Asp Cys Glu Tyr Lys Arg Gly Ile Lys Glu Thr
        515                 520                 525             
Thr Cys Thr Asp Leu Asp Gly Phe Trp Asp Met Val Ser Phe Gln Ile
    530                 535                 540                 
Glu Asp Val Ile His Lys Phe Asn Asn Leu Ile Lys Leu Glu Glu Ser
545                 550                 555                 560 
Gly Trp Gln Val Asn Asn Asn Met Asn His Asn Met Asn Lys Asn Val
                565                 570                 575     
Phe Arg Lys Lys Val Val Ser Gly Ile Ala Ser Lys Pro Lys Gln Asp
            580                 585                 590         
Asp Ala Gly Arg Ile Ala Ala Arg Asn Arg Leu Ala Ala Ile Lys Asn
        595                 600                 605             
Ala Met Arg Glu Arg Ile Arg Gln Glu Glu Cys Ala Glu Thr Ala Val
    610                 615                 620                 
Ser Val Ile Pro Lys Glu Val Asp Lys Ile Val Phe Asp Ala Gly Phe
625                 630                 635                 640 
Phe Arg Val Glu Ser Pro Val Lys Leu Phe Ser Gly Leu Ser Val Ser
                645                 650                 655     
Ser Glu Gly Pro Ser Gln Arg Leu Gly Thr Pro Lys Ser Val Asn Lys
            660                 665                 670         
Ala Val Ser Gln Ser Arg Asn Glu Met Gly Ile Pro Gln Gln Thr Thr
        675                 680                 685             
Ser Pro Glu Asn Ala Gly Pro Gln Asn Thr Lys Ser Glu His Val Lys
    690                 695                 700                 
Lys Thr Leu Phe Leu Ser Ile Pro Glu Ser Arg Ser Ser Ile Glu Asp
705                 710                 715                 720 
Ala Gln Cys Pro Gly Leu Pro Asp Leu Ile Glu Glu Asn His Val Val
                725                 730                 735     
Asn Lys Thr Asp Leu Lys Val Asp Cys Leu Ser Ser Glu Arg Met Ser
            740                 745                 750         
Leu Pro Leu Leu Ala Gly Gly Val Ala Asp Asp Ile Asn Thr Asn Lys
        755                 760                 765             
Lys Glu Gly Ile Ser Asp Val Val Glu Gly Met Glu Leu Asn Ser Ser
    770                 775                 780                 
Ile Thr Ser Gln Asp Val Leu Met Ser Ser Pro Glu Lys Asn Thr Ala
785                 790                 795                 800 
Ser Gln Asn Ser Ile Leu Glu Glu Gly Glu Thr Lys Ile Ser Gln Ser
                805                 810                 815     
Glu Leu Phe Asp Asn Lys Ser Leu Thr Thr Glu Cys His Leu Leu Asp
            820                 825                 830         
Ser Val Gly Ser Cys Tyr Val Ala Arg Ala Gly Leu Glu Val Leu Gly
        835                 840                 845             
Ser Ser Asp Pro Thr Thr Ser Ala Ser Arg Val Ala Gly Thr Thr Ala
    850                 855                 860                 
Arg Ser Lys Leu Gln
865                 


<210> 6624
<211> 846
<212> PRT
<213> Homo sapiens

<400> 6624
Met Ser Ser Ser His Phe Ala Ser Arg His Arg Lys Asp Ile Ser Thr
 1               5                  10                  15      
Glu Met Ile Arg Thr Lys Ile Ala His Arg Lys Ser Leu Ser Gln Lys
            20                  25                  30          
Glu Asn Arg His Lys Glu Tyr Glu Arg Asn Arg His Phe Gly Leu Lys
        35                  40                  45              
Asp Val Asn Ile Pro Thr Leu Glu Gly Arg Ile Leu Val Glu Leu Asp
    50                  55                  60                  
Glu Thr Ser Gln Glu Leu Val Pro Glu Lys Thr Asn Val Lys Pro Arg
65                  70                  75                  80  
Ala Met Lys Thr Ile Leu Gly Asp Gln Arg Lys Gln Met Leu Gln Lys
                85                  90                  95      
Tyr Lys Glu Glu Lys Gln Leu Gln Lys Leu Lys Glu Gln Arg Glu Lys
            100                 105                 110         
Ala Lys Arg Gly Ile Phe Lys Val Gly Arg Tyr Arg Pro Asp Met Pro
        115                 120                 125             
Cys Phe Leu Leu Ser Asn Gln Asn Ala Val Lys Ala Glu Pro Lys Lys
    130                 135                 140                 
Ala Ile Pro Ser Ser Val Arg Ile Thr Arg Ser Lys Ala Lys Asp Gln
145                 150                 155                 160 
Met Glu Gln Thr Lys Ile Asp Asn Glu Ser Asp Val Arg Ala Ile Arg
                165                 170                 175     
Pro Gly Pro Arg Gln Thr Ser Glu Lys Lys Val Ser Asp Lys Glu Lys
            180                 185                 190         
Lys Val Val Gln Pro Val Met Pro Thr Ser Leu Arg Met Thr Arg Ser
        195                 200                 205             
Ala Thr Gln Ala Ala Lys Gln Val Pro Arg Thr Val Ser Ser Thr Thr
    210                 215                 220                 
Ala Arg Lys Pro Val Thr Arg Ala Ala Asn Glu Asn Glu Pro Glu Gly
225                 230                 235                 240 
Lys Val Pro Ser Lys Gly Arg Pro Ala Lys Asn Val Glu Thr Lys Pro
                245                 250                 255     
Asp Lys Gly Ile Ser Cys Lys Val Asp Ser Glu Glu Asn Thr Leu Asn
            260                 265                 270         
Ser Gln Thr Asn Ala Thr Ser Gly Met Asn Pro Asp Gly Val Leu Ser
        275                 280                 285             
Lys Met Glu Asn Leu Pro Glu Ile Asn Thr Ala Lys Ile Lys Gly Lys
    290                 295                 300                 
Asn Ser Phe Ala Pro Lys Asp Phe Met Phe Gln Pro Leu Asp Gly Leu
305                 310                 315                 320 
Lys Thr Tyr Gln Val Thr Pro Met Thr Pro Arg Ser Ala Asn Ala Phe
                325                 330                 335     
Leu Thr Pro Ser Tyr Thr Trp Thr Pro Leu Lys Thr Glu Val Asp Glu
            340                 345                 350         
Ser Gln Ala Thr Lys Glu Ile Leu Ala Gln Lys Cys Lys Thr Tyr Ser
        355                 360                 365             
Thr Lys Thr Ile Gln Gln Asp Ser Asn Lys Leu Pro Cys Pro Leu Gly
    370                 375                 380                 
Pro Leu Thr Val Trp His Glu Glu His Val Leu Asn Lys Asn Glu Ala
385                 390                 395                 400 
Thr Thr Lys Asn Leu Asn Gly Leu Pro Ile Lys Glu Val Pro Ser Leu
                405                 410                 415     
Glu Arg Asn Glu Gly Arg Ile Ala Gln Pro His His Gly Val Pro Tyr
            420                 425                 430         
Phe Arg Asn Ile Leu Gln Ser Glu Thr Glu Lys Leu Thr Ser His Cys
        435                 440                 445             
Phe Glu Trp Asp Arg Lys Leu Glu Leu Asp Ile Pro Asp Asp Ala Lys
    450                 455                 460                 
Asp Leu Ile Arg Thr Ala Val Gly Gln Thr Arg Leu Leu Met Lys Glu
465                 470                 475                 480 
Arg Phe Lys Gln Phe Glu Gly Leu Val Asp Asp Cys Glu Tyr Lys Arg
                485                 490                 495     
Gly Ile Lys Glu Thr Thr Cys Thr Asp Leu Asp Gly Phe Trp Asp Met
            500                 505                 510         
Val Ser Phe Gln Ile Glu Asp Val Ile His Lys Phe Asn Asn Leu Ile
        515                 520                 525             
Lys Leu Glu Glu Ser Gly Trp Gln Val Asn Asn Asn Met Asn His Asn
    530                 535                 540                 
Met Asn Lys Asn Val Phe Arg Lys Lys Val Val Ser Gly Ile Ala Ser
545                 550                 555                 560 
Lys Pro Lys Gln Asp Asp Ala Gly Arg Ile Ala Ala Arg Asn Arg Leu
                565                 570                 575     
Ala Ala Ile Lys Asn Ala Met Arg Glu Arg Ile Arg Gln Glu Glu Cys
            580                 585                 590         
Ala Glu Thr Ala Val Ser Val Ile Pro Lys Glu Val Asp Lys Ile Val
        595                 600                 605             
Phe Asp Ala Gly Phe Phe Arg Val Glu Ser Pro Val Lys Leu Phe Ser
    610                 615                 620                 
Gly Leu Ser Val Ser Ser Glu Gly Pro Ser Gln Arg Leu Gly Thr Pro
625                 630                 635                 640 
Lys Ser Val Asn Lys Ala Val Ser Gln Ser Arg Asn Glu Met Gly Ile
                645                 650                 655     
Pro Gln Gln Thr Thr Ser Pro Glu Asn Ala Gly Pro Gln Asn Thr Lys
            660                 665                 670         
Ser Glu His Val Lys Lys Thr Leu Phe Leu Ser Ile Pro Glu Ser Arg
        675                 680                 685             
Ser Ser Ile Glu Asp Ala Gln Cys Pro Gly Leu Pro Asp Leu Ile Glu
    690                 695                 700                 
Glu Asn His Val Val Asn Lys Thr Asp Leu Lys Val Asp Cys Leu Ser
705                 710                 715                 720 
Ser Glu Arg Met Ser Leu Pro Leu Leu Ala Gly Gly Val Ala Asp Asp
                725                 730                 735     
Ile Asn Thr Asn Lys Lys Glu Gly Ile Ser Asp Val Val Glu Gly Met
            740                 745                 750         
Glu Leu Asn Ser Ser Ile Thr Ser Gln Asp Val Leu Met Ser Ser Pro
        755                 760                 765             
Glu Lys Asn Thr Ala Ser Gln Asn Ser Ile Leu Glu Glu Gly Glu Thr
    770                 775                 780                 
Lys Ile Ser Gln Ser Glu Leu Phe Asp Asn Lys Ser Leu Thr Thr Glu
785                 790                 795                 800 
Cys His Leu Leu Asp Ser Pro Gly Leu Asn Cys Ser Asn Pro Phe Thr
                805                 810                 815     
Gln Leu Glu Arg Arg His Gln Glu His Ala Arg His Ile Ser Phe Gly
            820                 825                 830         
Gly Asn Leu Ile Thr Phe Ser Pro Leu Gln Pro Gly Glu Phe
        835                 840                 845     


<210> 6625
<211> 271
<212> PRT
<213> Homo sapiens

<400> 6625
Met Pro Gly Thr Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp
 1               5                  10                  15      
Pro Glu Val Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe
            20                  25                  30          
Gln Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn
        35                  40                  45              
Thr Lys Asn Phe Leu Val Leu Lys Lys Lys Lys Val Gly Ser Ser Leu
    50                  55                  60                  
Ala Gly Asp Ser Trp Gly Asn Leu Phe Leu Gly Ala Ser Gly Met Ala
65                  70                  75                  80  
Ser Gly Cys Lys Ile Gly Pro Ser Ile Leu Asn Ser Asp Leu Ala Asn
                85                  90                  95      
Leu Gly Ala Lys Cys Leu Gln Met Leu Asp Ser Gly Ala Asp Tyr Leu
            100                 105                 110         
His Leu Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Phe Gly
        115                 120                 125             
His Pro Val Val Glu Ser Leu Arg Lys Gln Leu Gly Gln Asp Pro Phe
    130                 135                 140                 
Phe Asp Met His Met Met Val Ser Lys Pro Glu Gln Trp Val Lys Pro
145                 150                 155                 160 
Met Ala Val Ala Glu Ala Asn Gln Tyr Thr Phe His Leu Glu Ala Thr
                165                 170                 175     
Glu Asn Pro Gly Thr Leu Ile Lys Asp Ile Arg Glu Asn Gly Met Lys
            180                 185                 190         
Val Gly Leu Ala Ile Lys Pro Gly Thr Ser Val His Trp Leu Arg Thr
        195                 200                 205             
Gln Phe Pro Ser Leu Asp Ile Glu Gly Asp Gly Gly Val Gly Ser Asp
    210                 215                 220                 
Thr Val His Lys Cys Ala Glu Ala Gly Ala Asn Met Thr Val Ser Gly
225                 230                 235                 240 
Ser Ala Ile Met Arg Ser Glu Asp Pro Arg Ser Val Ile Asn Leu Leu
                245                 250                 255     
Arg Asn Ile Cys Ser Glu Ala Ala Gln Lys Arg Ser Leu Asp Arg
            260                 265                 270     


<210> 6626
<211> 311
<212> PRT
<213> Homo sapiens

<400> 6626
Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Asn Met Cys
 1               5                  10                  15      
Lys Gln Asp Leu Ser Val Leu His Thr Glu Glu Met Cys Phe Leu Arg
            20                  25                  30          
Glu Trp Val Glu Ser Leu Ala Gly Lys Val Pro Pro Ala Thr Gln Lys
        35                  40                  45              
Ala Lys Ser Glu Glu Asn Ala Lys Glu Glu Lys Pro Asn Ser Lys Lys
    50                  55                  60                  
Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp
65                  70                  75                  80  
Leu Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro
                85                  90                  95      
Gln Glu Met Gly Gly Glu Asn Ala Glu Ile Thr Glu Glu Met Met Asp
            100                 105                 110         
Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly
        115                 120                 125             
Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn
    130                 135                 140                 
Pro Arg Leu Ala Val Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys
145                 150                 155                 160 
Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu
                165                 170                 175     
Ile Asn Pro Asp Ser Ala Gln Pro His Lys Trp Arg Gly Lys Ala His
            180                 185                 190         
Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala
        195                 200                 205             
Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Val Met Leu Lys Glu Val
    210                 215                 220                 
Gln Leu Arg Ala Gln Lys Ile Ala Glu His Gln Arg Lys Tyr Glu Gln
225                 230                 235                 240 
Lys Arg Glu Glu Gly Met Pro Gly Met Ala Gly Met Pro Gly Leu Asn
                245                 250                 255     
Glu Ile Leu Ser Asp Pro Glu Val Leu Ala Thr Ile Gln Asp Pro Glu
            260                 265                 270         
Val Met Val Ala Phe Gln Asp Val Ala Gln Asn Pro Ala Asn Met Ser
        275                 280                 285             
Lys Tyr Gln Ser Asn Pro Lys Val Met Asn Leu Ile Ser Lys Leu Ser
    290                 295                 300                 
Ala Lys Phe Gly Gly Gln Val
305                 310     


<210> 6627
<211> 310
<212> PRT
<213> Homo sapiens

<400> 6627
Ala Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro
 1               5                  10                  15      
Gln Glu Met Gly Asp Glu Asn Ala Glu Ile Thr Glu Glu Met Met Asp
            20                  25                  30          
Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly
        35                  40                  45              
Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn
    50                  55                  60                  
Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys
65                  70                  75                  80  
Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu
                85                  90                  95      
Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His
            100                 105                 110         
Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala
        115                 120                 125             
Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val
    130                 135                 140                 
Gln Pro Arg Ala Gln Lys Ile Ala Glu His Arg Arg Lys Tyr Glu Arg
145                 150                 155                 160 
Lys Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys
                165                 170                 175     
Ala Arg Glu Glu His Glu Arg Ala Gln Arg Thr Leu Gln Thr Thr Leu
            180                 185                 190         
Cys Leu Val Ala Pro Ile Phe Phe Glu Pro Val Leu Phe Val Asp Glu
        195                 200                 205             
Ile Leu Arg Ile Phe Gly Ser Met Ile Ser Val Tyr Ser Phe Phe Ile
    210                 215                 220                 
Thr Gly Gly Phe Pro Gly Gly Met Pro Gly Asn Phe Pro Gly Gly Met
225                 230                 235                 240 
Pro Gly Met Gly Gly Gly Met Pro Gly Met Ala Gly Met Pro Gly Leu
                245                 250                 255     
Asn Glu Ile Leu Ser Asp Pro Glu Val Leu Ala Ala Met Gln Asp Pro
            260                 265                 270         
Glu Val Met Val Ala Phe Gln Asp Val Ala Gln Asn Pro Ala Asn Met
        275                 280                 285             
Ser Lys Tyr Gln Ser Asn Pro Lys Val Met Asn Leu Ile Ser Lys Leu
    290                 295                 300                 
Ser Ala Lys Phe Gly Gly
305                 310 


<210> 6628
<211> 369
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 102, 272
<223> Xaa = Any Amino Acid

<400> 6628
Met Asp Pro His Lys Val Asn Glu Leu Trp Ala Phe Val Lys Met Cys
 1               5                  10                  15      
Lys Gln Asp Pro Ser Ile Leu His Thr Glu Glu Met His Phe Leu Arg
            20                  25                  30          
Glu Trp Val Glu Ser Thr Val Gly Lys Val Pro Pro Ala Thr Gln Lys
        35                  40                  45              
Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Arg
    50                  55                  60                  
Val Glu Glu Asp Leu Lys Ala Asp Glu Gln Ser Ser Glu Lys Ser Asp
65                  70                  75                  80  
Leu Glu Ile Asp Lys Glu Gly Val Thr Glu Pro Asp Thr Asp Ala Pro
                85                  90                  95      
Gln Glu Met Gly Asp Xaa Asn Ala Glu Ile Met Glu Glu Met Met Asp
            100                 105                 110         
Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Thr Leu Asn Asp Gly
        115                 120                 125             
Glu Leu Gln Lys Ala Thr Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn
    130                 135                 140                 
Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys
145                 150                 155                 160 
Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu
                165                 170                 175     
Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His
            180                 185                 190         
Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala
        195                 200                 205             
Cys Lys Leu Asp Tyr Asp Glu Asp Val Ser Ala Met Leu Lys Glu Val
    210                 215                 220                 
Gln Pro Arg Ala Gln Lys Ile Glu Glu His Arg Arg Lys Tyr Glu Arg
225                 230                 235                 240 
Lys Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys
                245                 250                 255     
Ala Arg Glu Lys His Glu Arg Ala Gln Arg Glu Glu Glu Ala Arg Xaa
            260                 265                 270         
Gln Ser Gly Ala Gln Tyr Gly Ser Phe Leu Gly Gly Phe Pro Gly Gly
        275                 280                 285             
Met Pro Ala Asn Phe Pro Arg Gly Met Pro Gly Met Gly Gly Gly Met
    290                 295                 300                 
Pro Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro
305                 310                 315                 320 
Glu Val Leu Ala Ala Met Gln Asp Pro Glu Val Leu Val Ala Phe Gln
                325                 330                 335     
Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro
            340                 345                 350         
Lys Val Met Asn Leu Ile Ser Lys Leu Ser Val Lys Phe Gly Gly Gln
        355                 360                 365             
Val
    


<210> 6629
<211> 369
<212> PRT
<213> Homo sapiens

<400> 6629
Met Asp Pro Cys Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys
 1               5                  10                  15      
Lys Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg
            20                  25                  30          
Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys
        35                  40                  45              
Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys
    50                  55                  60                  
Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Thr Glu Glu Ser Asp
65                  70                  75                  80  
Leu Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro
                85                  90                  95      
Gln Glu Met Gly Asp Glu Asn Val Glu Ile Thr Glu Glu Met Met Asp
            100                 105                 110         
Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Val Leu Asn Asp Gly
        115                 120                 125             
Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn
    130                 135                 140                 
Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys
145                 150                 155                 160 
Leu Gln Lys Pro Asn Ala Ala Ile Gln Asp Cys Asp Arg Ala Ile Glu
                165                 170                 175     
Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His
            180                 185                 190         
Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Phe Ala
        195                 200                 205             
Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val
    210                 215                 220                 
Gln Pro Arg Ala Gln Lys Ile Ala Glu His Trp Arg Lys Tyr Glu Arg
225                 230                 235                 240 
Lys His Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys
                245                 250                 255     
Ala Gln Glu Glu Gln Glu Arg Ala Gln Arg Glu Glu Glu Ala Arg Arg
            260                 265                 270         
Gln Ser Gly Ala His Tyr Gly Pro Phe Pro Gly Gly Phe Pro Gly Gly
        275                 280                 285             
Met Pro Gly Asn Phe Pro Gly Gly Met Pro Gly Met Gly Gly Asp Met
    290                 295                 300                 
Pro Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro
305                 310                 315                 320 
Glu Ala Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe Gln
                325                 330                 335     
Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro
            340                 345                 350         
Lys Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln
        355                 360                 365             
Ala
    


<210> 6630
<211> 289
<212> PRT
<213> Homo sapiens

<400> 6630
Met Val Ser Arg Leu Glu Glu His Arg Thr Gly Trp Gly Ser Pro Gln
 1               5                  10                  15      
Ala Asn Phe Arg Val Glu Arg His Ala Lys Lys Glu Arg Lys Val Gly
            20                  25                  30          
Leu Cys His Ile Ser Gly Phe Tyr Pro Asn Ala Leu Gln Ile Glu Val
        35                  40                  45              
Asn Thr Leu Arg Ala Phe Val Lys Met Cys Lys Gln Asp Leu Ser Val
    50                  55                  60                  
Leu His Thr Lys Glu Met Cys Phe Leu Arg Glu Trp Val Glu Ser Met
65                  70                  75                  80  
Gly Ser Lys Val Pro Pro Ala Ser Gln Lys Ala Lys Ser Glu Glu Asn
                85                  90                  95      
Thr Lys Glu Glu Lys Ser Gly Ser Lys Asn Val Glu Glu Asp Leu Lys
            100                 105                 110         
Ala Asp Glu Pro Ser Ser Lys Glu Ser Tyr Leu Glu Ile Asn Asn Glu
        115                 120                 125             
Gly Val Ile Glu Pro Asp Thr Asp Ala Pro Gln Glu Met Gly Asp Glu
    130                 135                 140                 
Asn Ala Glu Ile Thr Glu Glu Met Met Asp Gln Ala Asn Asp Lys Lys
145                 150                 155                 160 
Val Ala Ala Val Glu Ala Leu Asn Asp Gly Glu Leu Gln Lys Ala Ile
                165                 170                 175     
Asp Leu Ile Thr Asp Ser Ile Lys Leu Asn Pro His Leu Ala Ile Leu
            180                 185                 190         
Tyr Ala Lys Arg Ala Ser Val Phe Ile Lys Leu Gln Lys Pro Asn Ser
        195                 200                 205             
Ala Ile Arg Asp Cys Asp Arg Lys Asn Thr Trp Asn Gly Gly Gly Ile
    210                 215                 220                 
Pro Arg Met Ala Arg Arg Pro Gly Pro Asn Glu Ile Leu Ser Asp Pro
225                 230                 235                 240 
Glu Val Pro Ala Ala Leu Gln Asp Pro Glu Val Met Val Ala Phe Gln
                245                 250                 255     
Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro
            260                 265                 270         
Lys Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln
        275                 280                 285             
Ala
    


<210> 6631
<211> 369
<212> PRT
<213> Homo sapiens

<400> 6631
Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys
 1               5                  10                  15      
Lys Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg
            20                  25                  30          
Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys
        35                  40                  45              
Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys
    50                  55                  60                  
Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp
65                  70                  75                  80  
Leu Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro
                85                  90                  95      
Gln Glu Met Gly Asp Glu Asn Ala Glu Ile Thr Glu Glu Met Met Asp
            100                 105                 110         
Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly
        115                 120                 125             
Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn
    130                 135                 140                 
Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys
145                 150                 155                 160 
Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu
                165                 170                 175     
Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His
            180                 185                 190         
Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala
        195                 200                 205             
Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val
    210                 215                 220                 
Gln Pro Arg Ala Gln Lys Ile Ala Glu His Arg Arg Lys Tyr Glu Arg
225                 230                 235                 240 
Lys Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys
                245                 250                 255     
Ala Arg Glu Glu His Glu Arg Ala Gln Arg Glu Glu Glu Ala Arg Arg
            260                 265                 270         
Gln Ser Gly Ala Gln Tyr Gly Ser Phe Pro Gly Gly Phe Pro Gly Gly
        275                 280                 285             
Met Pro Gly Asn Phe Pro Gly Gly Met Pro Gly Met Gly Gly Gly Met
    290                 295                 300                 
Pro Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro
305                 310                 315                 320 
Glu Val Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe Gln
                325                 330                 335     
Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro
            340                 345                 350         
Lys Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln
        355                 360                 365             
Ala
    


<210> 6632
<211> 356
<212> PRT
<213> Homo sapiens

<400> 6632
Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu
 1               5                  10                  15      
Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met
            20                  25                  30          
Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro
        35                  40                  45              
Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala
    50                  55                  60                  
Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu
65                  70                  75                  80  
Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys
                85                  90                  95      
Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr
            100                 105                 110         
Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro
        115                 120                 125             
Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu
    130                 135                 140                 
Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys
145                 150                 155                 160 
Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr
                165                 170                 175     
Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro
            180                 185                 190         
Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly
        195                 200                 205             
Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His
    210                 215                 220                 
Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala
225                 230                 235                 240 
Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys
                245                 250                 255     
Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe
            260                 265                 270         
Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys
        275                 280                 285             
Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His
    290                 295                 300                 
Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys
305                 310                 315                 320 
Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser
                325                 330                 335     
Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn
            340                 345                 350         
Arg Cys Gly Gln
        355     


<210> 6633
<211> 570
<212> PRT
<213> Homo sapiens

<400> 6633
Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu
 1               5                  10                  15      
Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met
            20                  25                  30          
Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro
        35                  40                  45              
Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala
    50                  55                  60                  
Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu
65                  70                  75                  80  
Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys
                85                  90                  95      
Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr
            100                 105                 110         
Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro
        115                 120                 125             
Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu
    130                 135                 140                 
Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys
145                 150                 155                 160 
Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr
                165                 170                 175     
Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro
            180                 185                 190         
Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly
        195                 200                 205             
Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His
    210                 215                 220                 
Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala
225                 230                 235                 240 
Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys
                245                 250                 255     
Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe
            260                 265                 270         
Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys
        275                 280                 285             
Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His
    290                 295                 300                 
Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys
305                 310                 315                 320 
Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser
                325                 330                 335     
Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro
            340                 345                 350         
Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val
        355                 360                 365             
Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu
    370                 375                 380                 
Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu
385                 390                 395                 400 
Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu
                405                 410                 415     
Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu
            420                 425                 430         
Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly
        435                 440                 445             
Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu
    450                 455                 460                 
Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu
465                 470                 475                 480 
Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile
                485                 490                 495     
Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys
            500                 505                 510         
Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly
        515                 520                 525             
Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val
    530                 535                 540                 
Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln
545                 550                 555                 560 
Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val
                565                 570 


<210> 6634
<211> 346
<212> PRT
<213> Homo sapiens

<400> 6634
Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu
 1               5                  10                  15      
Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met
            20                  25                  30          
Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro
        35                  40                  45              
Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala
    50                  55                  60                  
Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu
65                  70                  75                  80  
Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys
                85                  90                  95      
Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr
            100                 105                 110         
Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro
        115                 120                 125             
Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu
    130                 135                 140                 
Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys
145                 150                 155                 160 
Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr
                165                 170                 175     
Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro
            180                 185                 190         
Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly
        195                 200                 205             
Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His
    210                 215                 220                 
Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala
225                 230                 235                 240 
Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys
                245                 250                 255     
Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe
            260                 265                 270         
Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys
        275                 280                 285             
Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ala Ser Ser
    290                 295                 300                 
Lys Ile His Ser Gly Thr Gly Leu Trp Phe Trp Ser His Ser Pro Ala
305                 310                 315                 320 
Ser Gly Asp Ser His Cys Cys Leu Pro Cys Leu Leu Ala Arg Asp Gly
                325                 330                 335     
Pro Ile Leu Pro Gly Ser Phe Trp Asn Arg
            340                 345     


<210> 6635
<211> 324
<212> PRT
<213> Homo sapiens

<400> 6635
Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu
 1               5                  10                  15      
Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met
            20                  25                  30          
Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro
        35                  40                  45              
Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala
    50                  55                  60                  
Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu
65                  70                  75                  80  
Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys
                85                  90                  95      
Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr
            100                 105                 110         
Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro
        115                 120                 125             
Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu
    130                 135                 140                 
Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys
145                 150                 155                 160 
Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr
                165                 170                 175     
Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro
            180                 185                 190         
Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly
        195                 200                 205             
Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His
    210                 215                 220                 
Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala
225                 230                 235                 240 
Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys
                245                 250                 255     
Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe
            260                 265                 270         
Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys
        275                 280                 285             
Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ala Ser Ser
    290                 295                 300                 
Lys Ile His Ser Gly Thr Gly Leu Trp Phe Trp Ser His Ser Pro Ala
305                 310                 315                 320 
Ser Gly Asp Ser
                


<210> 6636
<211> 540
<212> PRT
<213> Homo sapiens

<400> 6636
Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn
 1               5                  10                  15      
Glu Glu Arg Glu Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu
            20                  25                  30          
Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg
        35                  40                  45              
Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe
    50                  55                  60                  
Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg
65                  70                  75                  80  
Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala
                85                  90                  95      
Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr
            100                 105                 110         
Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu
        115                 120                 125             
Gly Phe Ser Ser Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn
    130                 135                 140                 
Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val
145                 150                 155                 160 
Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys
                165                 170                 175     
Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr
            180                 185                 190         
Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser
        195                 200                 205             
Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala
    210                 215                 220                 
Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His
225                 230                 235                 240 
Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu
                245                 250                 255     
Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly
            260                 265                 270         
Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser
        275                 280                 285             
Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys
    290                 295                 300                 
Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met
305                 310                 315                 320 
Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly
                325                 330                 335     
Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu
            340                 345                 350         
Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His
        355                 360                 365             
Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala
    370                 375                 380                 
Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu
385                 390                 395                 400 
Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu
                405                 410                 415     
Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser
            420                 425                 430         
Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr
        435                 440                 445             
Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu
    450                 455                 460                 
Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala
465                 470                 475                 480 
Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu
                485                 490                 495     
Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile
            500                 505                 510         
Lys His Lys Ala His Thr Gly Arg Gln Arg Arg Gly Ser Trp Thr Gly
        515                 520                 525             
Gln Ser Ser Arg Arg Asp Leu His Val Arg Val Leu
    530                 535                 540 


<210> 6637
<211> 552
<212> PRT
<213> Homo sapiens

<400> 6637
Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn
 1               5                  10                  15      
Glu Glu Arg Lys Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu
            20                  25                  30          
Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg
        35                  40                  45              
Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe
    50                  55                  60                  
Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg
65                  70                  75                  80  
Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala
                85                  90                  95      
Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr
            100                 105                 110         
Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu
        115                 120                 125             
Gly Phe Ser Ser Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn
    130                 135                 140                 
Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val
145                 150                 155                 160 
Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys
                165                 170                 175     
Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr
            180                 185                 190         
Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser
        195                 200                 205             
Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala
    210                 215                 220                 
Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His
225                 230                 235                 240 
Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu
                245                 250                 255     
Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly
            260                 265                 270         
Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser
        275                 280                 285             
Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys
    290                 295                 300                 
Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met
305                 310                 315                 320 
Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly
                325                 330                 335     
Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu
            340                 345                 350         
Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His
        355                 360                 365             
Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala
    370                 375                 380                 
Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu
385                 390                 395                 400 
Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu
                405                 410                 415     
Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser
            420                 425                 430         
Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr
        435                 440                 445             
Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu
    450                 455                 460                 
Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala
465                 470                 475                 480 
Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu
                485                 490                 495     
Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile
            500                 505                 510         
Lys His Lys Val Arg Asp Leu Val Pro Ser Ser Arg Val Val Arg Leu
        515                 520                 525             
Gly Glu Gly Gly Pro Asp Ser Asp Gln Ala Ile Arg Asp Arg Phe Ser
    530                 535                 540                 
Arg Leu Arg Tyr Gln Ser Glu Ala
545                 550         


<210> 6638
<211> 1074
<212> PRT
<213> Homo sapiens

<400> 6638
Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg
 1               5                  10                  15      
Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr
            20                  25                  30          
His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln
        35                  40                  45              
Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr
    50                  55                  60                  
Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr
65                  70                  75                  80  
Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala
                85                  90                  95      
Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala
            100                 105                 110         
His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro
        115                 120                 125             
Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser
    130                 135                 140                 
Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr
145                 150                 155                 160 
Tyr Gln Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln
                165                 170                 175     
Pro Gln Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala
            180                 185                 190         
Gly Tyr Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg
        195                 200                 205             
Gln Val Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr
    210                 215                 220                 
Phe Ser Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala
225                 230                 235                 240 
Ala Thr Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr
                245                 250                 255     
Ala Val Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val
            260                 265                 270         
Tyr Ser Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys
        275                 280                 285             
Gln Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr
    290                 295                 300                 
Gly Thr Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys
305                 310                 315                 320 
Pro Lys Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys
                325                 330                 335     
Lys Ile Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly
            340                 345                 350         
Gln Lys His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr
        355                 360                 365             
Ser Ser Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys
    370                 375                 380                 
Glu Leu Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His
385                 390                 395                 400 
Ile Arg Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu
                405                 410                 415     
Gly Lys Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr
            420                 425                 430         
Ser Ser Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser
        435                 440                 445             
Ile Ala Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser
    450                 455                 460                 
Ser Met Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr
465                 470                 475                 480 
Ser Asn Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys
                485                 490                 495     
Thr Ser Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser
            500                 505                 510         
Thr Gly Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser
        515                 520                 525             
Thr Pro Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr
    530                 535                 540                 
Val Ser Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp
545                 550                 555                 560 
Val Gln Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu
                565                 570                 575     
Gly Lys Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn
            580                 585                 590         
Asp Pro Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu
        595                 600                 605             
Gln Tyr Lys Lys Lys Val Asn Pro Asp Leu Gln Val Glu Val Lys Pro
    610                 615                 620                 
Ser Ile Arg Ala Arg Lys Ile Gln Glu Glu Lys Met Arg Lys Gln Met
625                 630                 635                 640 
Gln Lys Glu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg
                645                 650                 655     
Met Glu Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu
            660                 665                 670         
Glu Glu Gln His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly
        675                 680                 685             
Tyr Pro His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro
    690                 695                 700                 
Gly Met Pro Pro Gln Pro Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp
705                 710                 715                 720 
Ser Ser Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro
                725                 730                 735     
Thr Glu Glu Glu Leu Gln Ala Val Gln Lys Ile Val Ser Ile Thr Glu
            740                 745                 750         
Arg Ala Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn
        755                 760                 765             
Lys Asn Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala
    770                 775                 780                 
Leu Lys Gly Val Leu Arg Val Gly Val Leu Ala Lys Gly Leu Leu Leu
785                 790                 795                 800 
Arg Gly Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro
                805                 810                 815     
Ser Lys Thr Leu Leu Ser Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu
            820                 825                 830         
Ala Val Ile Ser Pro Glu Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu
        835                 840                 845             
Ala Ala Ile Ile Leu Asn Ser Cys Val Glu Pro Lys Met Gln Val Thr
    850                 855                 860                 
Ile Thr Leu Thr Ser Pro Ile Ile Arg Glu Glu Asn Met Arg Glu Gly
865                 870                 875                 880 
Asp Val Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg
                885                 890                 895     
Gln Lys Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe
            900                 905                 910         
Gln Ala Arg Ala Asn Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile
        915                 920                 925             
Leu Arg Asp Leu Cys Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser
    930                 935                 940                 
Trp Ala Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser
945                 950                 955                 960 
Pro Gln Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser
                965                 970                 975     
Ser Gly Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu
            980                 985                 990         
Lys Asp Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu
        995                 1000                1005            
Asp Ile Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg
    1010                1015                1020                
Gln Ile His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln
1025                1030                1035                1040
Arg Phe Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly
                1045                1050                1055    
Val Asp Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp
            1060                1065                1070        
Asn Phe
        


<210> 6639
<211> 443
<212> PRT
<213> Homo sapiens

<400> 6639
Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala
 1               5                  10                  15      
Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu
            20                  25                  30          
Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile
        35                  40                  45              
Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg
    50                  55                  60                  
Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala
65                  70                  75                  80  
Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu
                85                  90                  95      
Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn
            100                 105                 110         
Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp
        115                 120                 125             
Gly Phe Glu Ala Val Lys Lys Pro Asp Cys Tyr Tyr Ser Ile Gly Arg
    130                 135                 140                 
Glu Asn Tyr Asn Gln Tyr Asp Leu Asn Arg Asn Phe Pro Asp Ala Phe
145                 150                 155                 160 
Glu Tyr Asn Asn Val Ser Arg Gln Pro Glu Thr Val Ala Val Met Lys
                165                 170                 175     
Trp Leu Lys Thr Glu Thr Phe Val Leu Ser Ala Asn Leu His Gly Gly
            180                 185                 190         
Ala Leu Val Ala Ser Tyr Pro Phe Asp Asn Gly Val Gln Ala Thr Gly
        195                 200                 205             
Ala Leu Tyr Ser Arg Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr
    210                 215                 220                 
Leu Ala His Thr Tyr Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp
225                 230                 235                 240 
Glu Cys Lys Asn Lys Met Asn Phe Pro Asn Gly Val Thr Asn Gly Tyr
                245                 250                 255     
Ser Trp Tyr Pro Leu Gln Gly Gly Met Gln Asp Tyr Asn Tyr Ile Trp
            260                 265                 270         
Ala Gln Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro
        275                 280                 285             
Arg Glu Glu Lys Leu Pro Ser Phe Trp Asn Asn Asn Lys Ala Ser Leu
    290                 295                 300                 
Ile Glu Tyr Ile Lys Gln Val His Leu Gly Val Lys Gly Gln Val Phe
305                 310                 315                 320 
Asp Gln Asn Gly Asn Pro Leu Pro Asn Val Ile Val Glu Val Gln Asp
                325                 330                 335     
Arg Lys His Ile Cys Pro Tyr Arg Thr Asn Lys Tyr Gly Glu Tyr Tyr
            340                 345                 350         
Leu Leu Leu Leu Pro Gly Ser Tyr Ile Ile Asn Val Thr Val Pro Gly
        355                 360                 365             
His Asp Pro His Ile Thr Lys Val Ile Ile Pro Glu Lys Ser Gln Asn
    370                 375                 380                 
Phe Ser Ala Leu Lys Lys Asp Ile Leu Leu Pro Phe Gln Gly Gln Leu
385                 390                 395                 400 
Asp Ser Ile Pro Val Ser Asn Pro Ser Cys Pro Met Ile Pro Leu Tyr
                405                 410                 415     
Arg Asn Leu Pro Asp His Ser Ala Ala Thr Lys Pro Ser Leu Phe Leu
            420                 425                 430         
Phe Leu Val Ser Leu Leu His Ile Phe Phe Lys
        435                 440             


<210> 6640
<211> 968
<212> PRT
<213> Homo sapiens

<400> 6640
Met Arg Ser Glu Ala Leu Leu Leu Tyr Phe Thr Leu Leu His Phe Ala
 1               5                  10                  15      
Gly Ala Gly Phe Pro Glu Asp Ser Glu Pro Ile Ser Ile Ser His Gly
            20                  25                  30          
Asn Tyr Thr Lys Gln Tyr Pro Val Phe Val Gly His Lys Pro Gly Arg
        35                  40                  45              
Asn Thr Thr Gln Arg His Arg Leu Asp Ile Gln Met Ile Met Ile Met
    50                  55                  60                  
Asn Gly Thr Leu Tyr Ile Ala Ala Arg Asp His Ile Tyr Thr Val Asp
65                  70                  75                  80  
Ile Asp Thr Ser His Thr Glu Glu Ile Tyr Cys Ser Lys Lys Leu Thr
                85                  90                  95      
Trp Lys Ser Arg Gln Ala Asp Val Asp Thr Cys Arg Met Lys Gly Lys
            100                 105                 110         
His Lys Asp Glu Cys His Asn Phe Ile Lys Val Leu Leu Lys Lys Asn
        115                 120                 125             
Asp Asp Ala Leu Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Ser Cys
    130                 135                 140                 
Arg Asn Tyr Lys Met Asp Thr Leu Glu Pro Phe Gly Asp Glu Phe Ser
145                 150                 155                 160 
Gly Met Ala Arg Cys Pro Tyr Asp Ala Lys His Ala Asn Val Ala Leu
                165                 170                 175     
Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Thr Asp Phe Leu Ala
            180                 185                 190         
Ile Asp Ala Val Ile Tyr Arg Ser Leu Gly Glu Ser Pro Thr Leu Arg
        195                 200                 205             
Thr Val Lys His Asp Ser Lys Trp Leu Lys Glu Pro Tyr Phe Val Gln
    210                 215                 220                 
Ala Val Asp Tyr Gly Asp Tyr Ile Tyr Phe Phe Phe Arg Glu Ile Ala
225                 230                 235                 240 
Val Glu Tyr Asn Thr Met Gly Lys Val Val Phe Pro Arg Val Ala Gln
                245                 250                 255     
Val Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys Gln
            260                 265                 270         
Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly Asp
        275                 280                 285             
Ser His Phe Tyr Phe Asn Ile Leu Gln Ala Val Thr Asp Val Ile Arg
    290                 295                 300                 
Ile Asn Gly Arg Asp Val Val Leu Ala Thr Phe Ser Thr Pro Tyr Asn
305                 310                 315                 320 
Ser Ile Pro Gly Ser Ala Val Cys Ala Tyr Asp Met Leu Asp Ile Ala
                325                 330                 335     
Ser Val Phe Thr Gly Arg Phe Lys Glu Gln Lys Ser Pro Asp Ser Thr
            340                 345                 350         
Trp Thr Pro Val Pro Asp Glu Arg Val Pro Lys Pro Arg Pro Gly Cys
        355                 360                 365             
Cys Ala Gly Ser Ser Ser Leu Glu Arg Tyr Ala Thr Ser Asn Glu Phe
    370                 375                 380                 
Pro Asp Asp Thr Leu Asn Phe Ile Lys Thr His Pro Leu Met Asp Glu
385                 390                 395                 400 
Ala Val Pro Ser Ile Phe Asn Arg Pro Trp Phe Leu Arg Thr Met Val
                405                 410                 415     
Arg Tyr Arg Leu Thr Lys Ile Ala Val Asp Thr Ala Ala Gly Pro Tyr
            420                 425                 430         
Gln Asn His Thr Val Val Phe Leu Gly Ser Glu Lys Gly Ile Ile Leu
        435                 440                 445             
Lys Phe Leu Ala Arg Ile Gly Asn Ser Gly Phe Leu Asn Asp Ser Leu
    450                 455                 460                 
Phe Leu Glu Glu Met Ser Val Tyr Asn Ser Glu Lys Cys Ser Tyr Asp
465                 470                 475                 480 
Gly Val Glu Asp Lys Arg Ile Met Gly Met Gln Leu Asp Arg Ala Ser
                485                 490                 495     
Ser Ser Leu Tyr Val Ala Phe Ser Thr Cys Val Ile Lys Val Pro Leu
            500                 505                 510         
Gly Arg Cys Glu Arg Tyr Gly Lys Cys Lys Lys Thr Cys Ile Ala Ser
        515                 520                 525             
Arg Asp Pro Tyr Cys Gly Trp Ile Lys Glu Gly Gly Ala Cys Ser His
    530                 535                 540                 
Leu Ser Pro Asn Ser Arg Leu Thr Phe Glu Gln Asp Ile Glu Arg Gly
545                 550                 555                 560 
Asn Thr Asp Gly Leu Gly Asp Cys His Arg Val Ile Arg Glu Ser Tyr
                565                 570                 575     
Leu Lys Gly His Asp Gln Leu Val Pro Val Thr Leu Leu Ala Ile Ala
            580                 585                 590         
Val Ile Leu Ala Phe Val Met Gly Ala Val Phe Ser Gly Ile Thr Val
        595                 600                 605             
Tyr Cys Val Cys Asp His Arg Arg Lys Asp Val Ala Val Val Gln Arg
    610                 615                 620                 
Lys Glu Lys Glu Leu Thr His Ser Arg Arg Gly Ser Met Ser Ser Val
625                 630                 635                 640 
Thr Lys Leu Ser Gly Leu Phe Gly Asp Thr Gln Ser Lys Asp Pro Lys
                645                 650                 655     
Pro Glu Ala Ile Leu Thr Pro Leu Met His Asn Gly Lys Leu Ala Thr
            660                 665                 670         
Pro Gly Asn Thr Ala Lys Met Leu Ile Lys Ala Asp Gln His His Leu
        675                 680                 685             
Asp Leu Thr Ala Leu Pro Thr Pro Glu Ser Thr Pro Thr Leu Gln Gln
    690                 695                 700                 
Lys Arg Lys Pro Ser Arg Gly Ser Arg Glu Trp Glu Arg Asn Gln Asn
705                 710                 715                 720 
Leu Ile Asn Ala Cys Thr Lys Asp Met Pro Pro Met Gly Ser Pro Val
                725                 730                 735     
Ile Pro Thr Asp Leu Pro Leu Arg Ala Ser Pro Ser His Ile Pro Ser
            740                 745                 750         
Val Val Val Leu Pro Ile Thr Gln Gln Gly Tyr Gln His Glu Tyr Val
        755                 760                 765             
Asp Gln Pro Lys Met Ser Glu Val Ala Gln Met Ala Leu Glu Asp Gln
    770                 775                 780                 
Ala Ala Thr Leu Glu Tyr Lys Thr Ile Lys Glu His Leu Ser Ser Lys
785                 790                 795                 800 
Ser Pro Asn His Gly Val Asn Leu Val Glu Asn Leu Asp Ser Leu Pro
                805                 810                 815     
Pro Lys Val Pro Gln Arg Glu Ala Ser Leu Gly Pro Pro Gly Ala Ser
            820                 825                 830         
Leu Ser Gln Thr Gly Leu Ser Lys Arg Leu Glu Met His His Ser Ser
        835                 840                 845             
Ser Tyr Gly Val Asp Tyr Lys Arg Ser Tyr Pro Thr Asn Ser Leu Thr
    850                 855                 860                 
Arg Ser His Gln Ala Thr Thr Leu Lys Arg Asn Asn Thr Asn Ser Ser
865                 870                 875                 880 
Asn Ser Ser His Leu Ser Arg Asn Gln Ser Phe Gly Arg Gly Asp Asn
                885                 890                 895     
Pro Pro Pro Ala Pro Gln Arg Val Asp Ser Ile Gln Val His Ser Ser
            900                 905                 910         
Gln Pro Ser Gly Gln Ala Val Thr Val Ser Arg Gln Pro Ser Leu Asn
        915                 920                 925             
Ala Tyr Asn Ser Leu Thr Arg Ser Gly Leu Lys Arg Thr Pro Ser Leu
    930                 935                 940                 
Lys Pro Asp Val Pro Pro Lys Pro Ser Phe Ala Pro Leu Ser Thr Ser
945                 950                 955                 960 
Met Lys Pro Asn Asp Ala Cys Thr
                965             


<210> 6641
<211> 1030
<212> PRT
<213> Homo sapiens

<400> 6641
Met Arg Ser Glu Ala Leu Leu Leu Tyr Phe Thr Leu Leu His Phe Ala
 1               5                  10                  15      
Gly Ala Gly Phe Pro Glu Asp Ser Glu Pro Ile Ser Ile Ser His Gly
            20                  25                  30          
Asn Tyr Thr Lys Gln Tyr Pro Val Phe Val Gly His Lys Pro Gly Arg
        35                  40                  45              
Asn Thr Thr Gln Arg His Arg Leu Asp Ile Gln Met Ile Met Ile Met
    50                  55                  60                  
Asn Gly Thr Leu Tyr Ile Ala Ala Arg Asp His Ile Tyr Thr Val Asp
65                  70                  75                  80  
Ile Asp Thr Ser His Thr Glu Glu Ile Tyr Cys Ser Lys Lys Leu Thr
                85                  90                  95      
Trp Lys Ser Arg Gln Ala Asp Val Asp Thr Cys Arg Met Lys Gly Lys
            100                 105                 110         
His Lys Asp Glu Cys His Asn Phe Ile Lys Val Leu Leu Lys Lys Asn
        115                 120                 125             
Asp Asp Ala Leu Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Ser Cys
    130                 135                 140                 
Arg Asn Tyr Lys Met Asp Thr Leu Glu Pro Phe Gly Asp Glu Phe Ser
145                 150                 155                 160 
Gly Met Ala Arg Cys Pro Tyr Asp Ala Lys His Ala Asn Val Ala Leu
                165                 170                 175     
Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Thr Asp Phe Leu Ala
            180                 185                 190         
Ile Asp Ala Val Ile Tyr Arg Ser Leu Gly Glu Ser Pro Thr Leu Arg
        195                 200                 205             
Thr Val Lys His Asp Ser Lys Trp Leu Lys Glu Pro Tyr Phe Val Gln
    210                 215                 220                 
Ala Val Asp Tyr Gly Asp Tyr Ile Tyr Phe Phe Phe Arg Glu Ile Ala
225                 230                 235                 240 
Val Glu Tyr Asn Thr Met Gly Lys Val Val Phe Pro Arg Val Ala Gln
                245                 250                 255     
Val Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys Gln
            260                 265                 270         
Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly Asp
        275                 280                 285             
Ser His Phe Tyr Phe Asn Ile Leu Gln Ala Val Thr Asp Val Ile Arg
    290                 295                 300                 
Ile Asn Gly Arg Asp Val Val Leu Ala Thr Phe Ser Thr Pro Tyr Asn
305                 310                 315                 320 
Ser Ile Pro Gly Ser Ala Val Cys Ala Tyr Asp Met Leu Asp Ile Ala
                325                 330                 335     
Ser Val Phe Thr Gly Arg Phe Lys Glu Gln Lys Ser Pro Asp Ser Thr
            340                 345                 350         
Trp Thr Pro Val Pro Asp Glu Arg Val Pro Lys Pro Arg Pro Gly Cys
        355                 360                 365             
Cys Ala Gly Ser Ser Ser Leu Glu Arg Tyr Ala Thr Ser Asn Glu Phe
    370                 375                 380                 
Pro Asp Asp Thr Leu Asn Phe Ile Lys Thr His Pro Leu Met Asp Glu
385                 390                 395                 400 
Ala Val Pro Ser Ile Phe Asn Arg Pro Trp Phe Leu Arg Thr Met Val
                405                 410                 415     
Arg Tyr Arg Leu Thr Lys Ile Ala Val Asp Thr Ala Ala Gly Pro Tyr
            420                 425                 430         
Gln Asn His Thr Val Val Phe Leu Gly Ser Glu Lys Gly Ile Ile Leu
        435                 440                 445             
Lys Phe Leu Ala Arg Ile Gly Asn Ser Gly Phe Leu Asn Asp Ser Leu
    450                 455                 460                 
Phe Leu Glu Glu Met Ser Val Tyr Asn Ser Glu Lys Cys Ser Tyr Asp
465                 470                 475                 480 
Gly Val Glu Asp Lys Arg Ile Met Gly Met Gln Leu Asp Arg Ala Ser
                485                 490                 495     
Ser Ser Leu Tyr Val Ala Phe Ser Thr Cys Val Ile Lys Val Pro Leu
            500                 505                 510         
Gly Arg Cys Glu Arg His Gly Lys Cys Lys Lys Thr Cys Ile Ala Ser
        515                 520                 525             
Arg Asp Pro Tyr Cys Gly Trp Ile Lys Glu Gly Gly Ala Cys Ser His
    530                 535                 540                 
Leu Ser Pro Asn Ser Arg Leu Thr Phe Glu Gln Asp Ile Glu Arg Gly
545                 550                 555                 560 
Asn Thr Asp Gly Leu Gly Asp Cys His Asn Ser Phe Val Ala Leu Asn
                565                 570                 575     
Gly His Ser Ser Ser Leu Leu Pro Ser Thr Thr Thr Ser Asp Ser Thr
            580                 585                 590         
Ala Gln Glu Gly Tyr Glu Ser Arg Gly Gly Met Leu Asp Trp Lys His
        595                 600                 605             
Leu Leu Asp Ser Pro Asp Ser Thr Asp Pro Leu Gly Ala Val Ser Ser
    610                 615                 620                 
His Asn His Gln Asp Lys Lys Gly Val Ile Arg Glu Ser Tyr Leu Lys
625                 630                 635                 640 
Gly His Asp Gln Leu Val Pro Val Thr Leu Leu Ala Ile Ala Val Ile
                645                 650                 655     
Leu Ala Phe Val Met Gly Ala Val Phe Ser Gly Ile Thr Val Tyr Cys
            660                 665                 670         
Val Cys Asp His Arg Arg Lys Asp Val Ala Val Val Gln Arg Lys Glu
        675                 680                 685             
Lys Glu Leu Thr His Ser Arg Arg Gly Ser Met Ser Ser Val Thr Lys
    690                 695                 700                 
Leu Ser Gly Leu Phe Gly Asp Thr Gln Ser Lys Asp Pro Lys Pro Glu
705                 710                 715                 720 
Ala Ile Leu Thr Pro Leu Met His Asn Gly Lys Leu Ala Thr Pro Gly
                725                 730                 735     
Asn Thr Ala Lys Met Leu Ile Lys Ala Asp Gln His His Leu Asp Leu
            740                 745                 750         
Thr Ala Leu Pro Thr Pro Glu Ser Thr Pro Thr Leu Gln Gln Lys Arg
        755                 760                 765             
Lys Pro Ser Arg Gly Ser Arg Glu Trp Glu Arg Asn Gln Asn Leu Ile
    770                 775                 780                 
Asn Ala Cys Thr Lys Asp Met Pro Pro Met Gly Ser Pro Val Ile Pro
785                 790                 795                 800 
Thr Asp Leu Pro Leu Arg Ala Ser Pro Ser His Ile Pro Ser Val Val
                805                 810                 815     
Val Leu Pro Ile Thr Gln Gln Gly Tyr Gln His Glu Tyr Val Asp Gln
            820                 825                 830         
Pro Lys Met Ser Glu Val Ala Gln Met Ala Leu Glu Asp Gln Ala Ala
        835                 840                 845             
Thr Leu Glu Tyr Lys Thr Ile Lys Glu His Leu Ser Ser Lys Ser Pro
    850                 855                 860                 
Asn His Gly Val Asn Leu Val Glu Asn Leu Asp Ser Leu Pro Pro Lys
865                 870                 875                 880 
Val Pro Gln Arg Glu Ala Ser Leu Gly Pro Pro Gly Ala Ser Leu Ser
                885                 890                 895     
Gln Thr Gly Leu Ser Lys Arg Leu Glu Met His His Ser Ser Ser Tyr
            900                 905                 910         
Gly Val Asp Tyr Lys Arg Ser Tyr Pro Thr Asn Ser Leu Thr Arg Ser
        915                 920                 925             
His Gln Ala Thr Thr Leu Lys Arg Asn Asn Thr Asn Ser Ser Asn Ser
    930                 935                 940                 
Ser His Leu Ser Arg Asn Gln Ser Phe Gly Arg Gly Asp Asn Pro Pro
945                 950                 955                 960 
Pro Ala Pro Gln Arg Val Asp Ser Ile Gln Val His Ser Ser Gln Pro
                965                 970                 975     
Ser Gly Gln Ala Val Thr Val Ser Arg Gln Pro Ser Leu Asn Ala Tyr
            980                 985                 990         
Asn Ser Leu Thr Arg Ser Gly Leu Lys Arg Thr Pro Ser Leu Lys Pro
        995                 1000                1005            
Asp Val Pro Pro Lys Pro Ser Phe Ala Pro Leu Ser Thr Ser Met Lys
    1010                1015                1020                
Pro Asn Asp Ala Cys Thr
1025                1030


<210> 6642
<211> 1047
<212> PRT
<213> Homo sapiens

<400> 6642
Met Arg Ser Glu Ala Leu Leu Leu Tyr Phe Thr Leu Leu His Phe Ala
 1               5                  10                  15      
Gly Ala Gly Phe Pro Glu Asp Ser Glu Pro Ile Ser Ile Ser His Gly
            20                  25                  30          
Asn Tyr Thr Lys Gln Tyr Pro Val Phe Val Gly His Lys Pro Gly Arg
        35                  40                  45              
Asn Thr Thr Gln Arg His Arg Leu Asp Ile Gln Met Ile Met Ile Met
    50                  55                  60                  
Asn Gly Thr Leu Tyr Ile Ala Ala Arg Asp His Ile Tyr Thr Val Asp
65                  70                  75                  80  
Ile Asp Thr Ser His Thr Glu Glu Ile Tyr Cys Ser Lys Lys Leu Thr
                85                  90                  95      
Trp Lys Ser Arg Gln Ala Asp Val Asp Thr Cys Arg Met Lys Gly Lys
            100                 105                 110         
His Lys Asp Glu Cys His Asn Phe Ile Lys Val Leu Leu Lys Lys Asn
        115                 120                 125             
Asp Asp Ala Leu Phe Val Cys Gly Thr Asn Ala Phe Asn Pro Ser Cys
    130                 135                 140                 
Arg Asn Tyr Lys Met Asp Thr Leu Glu Pro Phe Gly Asp Glu Phe Ser
145                 150                 155                 160 
Gly Met Ala Arg Cys Pro Tyr Asp Ala Lys His Ala Asn Val Ala Leu
                165                 170                 175     
Phe Ala Asp Gly Lys Leu Tyr Ser Ala Thr Val Thr Asp Phe Leu Ala
            180                 185                 190         
Ile Asp Ala Val Ile Tyr Arg Ser Leu Gly Glu Ser Pro Thr Leu Arg
        195                 200                 205             
Thr Val Lys His Asp Ser Lys Trp Leu Lys Glu Pro Tyr Phe Val Gln
    210                 215                 220                 
Ala Val Asp Tyr Gly Asp Tyr Ile Tyr Phe Phe Phe Arg Glu Ile Ala
225                 230                 235                 240 
Val Glu Tyr Asn Thr Met Gly Lys Val Val Phe Pro Arg Val Ala Gln
                245                 250                 255     
Val Cys Lys Asn Asp Met Gly Gly Ser Gln Arg Val Leu Glu Lys Gln
            260                 265                 270         
Trp Thr Ser Phe Leu Lys Ala Arg Leu Asn Cys Ser Val Pro Gly Asp
        275                 280                 285             
Ser His Phe Tyr Phe Asn Ile Leu Gln Ala Val Thr Asp Val Ile Arg
    290                 295                 300                 
Ile Asn Gly Arg Asp Val Val Leu Ala Thr Phe Ser Thr Pro Tyr Asn
305                 310                 315                 320 
Ser Ile Pro Gly Ser Ala Val Cys Ala Tyr Asp Met Leu Asp Ile Ala
                325                 330                 335     
Ser Val Phe Thr Gly Arg Phe Lys Glu Gln Lys Ser Pro Asp Ser Thr
            340                 345                 350         
Trp Thr Pro Val Pro Asp Glu Arg Val Pro Lys Pro Arg Pro Gly Cys
        355                 360                 365             
Cys Ala Gly Ser Ser Ser Leu Glu Arg Tyr Ala Thr Ser Asn Glu Phe
    370                 375                 380                 
Pro Asp Asp Thr Leu Asn Phe Ile Lys Thr His Pro Leu Met Asp Glu
385                 390                 395                 400 
Ala Val Pro Ser Ile Phe Asn Arg Pro Trp Phe Leu Arg Thr Met Val
                405                 410                 415     
Arg Tyr Arg Leu Thr Lys Ile Ala Val Asp Thr Ala Ala Gly Pro Tyr
            420                 425                 430         
Gln Asn His Thr Val Val Phe Leu Gly Ser Glu Lys Gly Ile Ile Leu
        435                 440                 445             
Lys Phe Leu Ala Arg Ile Gly Asn Ser Gly Phe Leu Asn Asp Ser Leu
    450                 455                 460                 
Phe Leu Glu Glu Met Ser Val Tyr Asn Ser Glu Lys Cys Ser Tyr Asp
465                 470                 475                 480 
Gly Val Glu Asp Lys Arg Ile Met Gly Met Gln Leu Asp Arg Ala Ser
                485                 490                 495     
Ser Ser Leu Tyr Val Ala Phe Ser Thr Cys Val Ile Lys Val Pro Leu
            500                 505                 510         
Gly Arg Cys Glu Arg His Gly Lys Cys Lys Lys Thr Cys Ile Ala Ser
        515                 520                 525             
Arg Asp Pro Tyr Cys Gly Trp Ile Lys Glu Gly Gly Ala Cys Ser His
    530                 535                 540                 
Leu Ser Pro Asn Ser Arg Leu Thr Phe Glu Gln Asp Ile Glu Arg Gly
545                 550                 555                 560 
Asn Thr Asp Gly Leu Gly Asp Cys His Asn Ser Phe Val Ala Leu Asn
                565                 570                 575     
Asp Ile Ser Thr Pro Leu Pro Asp Asn Glu Met Ser Tyr Asn Thr Val
            580                 585                 590         
Tyr Gly His Ser Ser Ser Leu Leu Pro Ser Thr Thr Thr Ser Asp Ser
        595                 600                 605             
Thr Ala Gln Glu Gly Tyr Glu Ser Arg Gly Gly Met Leu Asp Trp Lys
    610                 615                 620                 
His Leu Leu Asp Ser Pro Asp Ser Thr Asp Pro Leu Gly Ala Val Ser
625                 630                 635                 640 
Ser His Asn His Gln Asp Lys Lys Gly Val Ile Arg Glu Ser Tyr Leu
                645                 650                 655     
Lys Gly His Asp Gln Leu Val Pro Val Thr Leu Leu Ala Ile Ala Val
            660                 665                 670         
Ile Leu Ala Phe Val Met Gly Ala Val Phe Ser Gly Ile Thr Val Tyr
        675                 680                 685             
Cys Val Cys Asp His Arg Arg Lys Asp Val Ala Val Val Gln Arg Lys
    690                 695                 700                 
Glu Lys Glu Leu Thr His Ser Arg Arg Gly Ser Met Ser Ser Val Thr
705                 710                 715                 720 
Lys Leu Ser Gly Leu Phe Gly Asp Thr Gln Ser Lys Asp Pro Lys Pro
                725                 730                 735     
Glu Ala Ile Leu Thr Pro Leu Met His Asn Gly Lys Leu Ala Thr Pro
            740                 745                 750         
Gly Asn Thr Ala Lys Met Leu Ile Lys Ala Asp Gln His His Leu Asp
        755                 760                 765             
Leu Thr Ala Leu Pro Thr Pro Glu Ser Thr Pro Thr Leu Gln Gln Lys
    770                 775                 780                 
Arg Lys Pro Ser Arg Gly Ser Arg Glu Trp Glu Arg Asn Gln Asn Leu
785                 790                 795                 800 
Ile Asn Ala Cys Thr Lys Asp Met Pro Pro Met Gly Ser Pro Val Ile
                805                 810                 815     
Pro Thr Asp Leu Pro Leu Arg Ala Ser Pro Ser His Ile Pro Ser Val
            820                 825                 830         
Val Val Leu Pro Ile Thr Gln Gln Gly Tyr Gln His Glu Tyr Val Asp
        835                 840                 845             
Gln Pro Lys Met Ser Glu Val Ala Gln Met Ala Leu Glu Asp Gln Ala
    850                 855                 860                 
Ala Thr Leu Glu Tyr Lys Thr Ile Lys Glu His Leu Ser Ser Lys Ser
865                 870                 875                 880 
Pro Asn His Gly Val Asn Leu Val Glu Asn Leu Asp Ser Leu Pro Pro
                885                 890                 895     
Lys Val Pro Gln Arg Glu Ala Ser Leu Gly Pro Pro Gly Ala Ser Leu
            900                 905                 910         
Ser Gln Thr Gly Leu Ser Lys Arg Leu Glu Met His His Ser Ser Ser
        915                 920                 925             
Tyr Gly Val Asp Tyr Lys Arg Ser Tyr Pro Thr Asn Ser Leu Thr Arg
    930                 935                 940                 
Ser His Gln Ala Thr Thr Leu Lys Arg Asn Asn Thr Asn Ser Ser Asn
945                 950                 955                 960 
Ser Ser His Leu Ser Arg Asn Gln Ser Phe Gly Arg Gly Asp Asn Pro
                965                 970                 975     
Pro Pro Ala Pro Gln Arg Val Asp Ser Ile Gln Val His Ser Ser Gln
            980                 985                 990         
Pro Ser Gly Gln Ala Val Thr Val Ser Arg Gln Pro Ser Leu Asn Ala
        995                 1000                1005            
Tyr Asn Ser Leu Thr Arg Ser Gly Leu Lys Arg Thr Pro Ser Leu Lys
    1010                1015                1020                
Pro Asp Val Pro Pro Lys Pro Ser Phe Ala Pro Leu Ser Thr Ser Met
1025                1030                1035                1040
Lys Pro Asn Asp Ala Cys Thr
                1045        


<210> 6643
<211> 409
<212> PRT
<213> Homo sapiens

<400> 6643
Met Arg Arg Tyr Leu Arg Val Val Val Leu Cys Val Ala Cys Gly Phe
 1               5                  10                  15      
Cys Ser Leu Leu Tyr Ala Phe Ser Gln Leu Ala Val Ser Leu Glu Glu
            20                  25                  30          
Gly Thr Gly Gly Gly Gly Gly Lys Pro Gln Ala Ala Val Ala Ser Trp
        35                  40                  45              
Leu Ala Gly Gly Gly Arg Gly Ala Val Arg Gly Ala Gly Val Ala Gly
    50                  55                  60                  
Pro Ala Ala His Pro Gly Val Ser Asp Arg Tyr Ser Leu Lys Ile Gln
65                  70                  75                  80  
Pro Val Glu Lys Met His Leu Ala Val Val Ala Cys Gly Glu Arg Leu
                85                  90                  95      
Glu Glu Thr Met Thr Met Leu Lys Ser Ala Ile Ile Phe Ser Ile Lys
            100                 105                 110         
Pro Leu Gln Phe His Ile Phe Ala Glu Asp Gln Leu His His Ser Phe
        115                 120                 125             
Lys Gly Arg Leu Asp Asn Trp Ser Phe Leu Gln Thr Phe Asn Tyr Thr
    130                 135                 140                 
Leu Tyr Pro Ile Thr Phe Pro Ser Glu Asn Ala Ala Glu Trp Lys Lys
145                 150                 155                 160 
Leu Phe Lys Pro Cys Ala Ser Gln Arg Leu Phe Leu Pro Leu Ile Leu
                165                 170                 175     
Lys Glu Val Asp Ser Leu Leu Tyr Val Asp Thr Asp Ile Leu Phe Leu
            180                 185                 190         
Arg Pro Val Asp Asp Ile Trp Ser Leu Leu Lys Lys Phe Asn Ser Thr
        195                 200                 205             
Gln Ile Ala Ala Met Ala Pro Glu His Glu Glu Pro Arg Ile Gly Trp
    210                 215                 220                 
Tyr Asn Arg Phe Ala Arg His Pro Tyr Tyr Gly Lys Thr Gly Val Asn
225                 230                 235                 240 
Ser Gly Val Met Leu Met Asn Met Thr Arg Met Arg Arg Lys Tyr Phe
                245                 250                 255     
Lys Asn Asp Met Thr Thr Val Arg Leu Gln Trp Gly Asp Ile Leu Met
            260                 265                 270         
Pro Leu Leu Lys Lys Tyr Lys Leu Asn Ile Thr Trp Gly Asp Gln Asp
        275                 280                 285             
Leu Leu Asn Ile Val Phe Phe His Asn Pro Glu Ser Leu Phe Val Phe
    290                 295                 300                 
Pro Cys Gln Trp Asn Tyr Arg Pro Asp His Cys Ile Tyr Gly Ser Asn
305                 310                 315                 320 
Cys Gln Glu Ala Glu Glu Gly Gly Ile Phe Ile Leu His Gly Asn Arg
                325                 330                 335     
Gly Val Tyr His Asp Asp Lys Gln Pro Ala Phe Arg Ala Val Tyr Glu
            340                 345                 350         
Ala Leu Arg Asn Cys Ser Phe Glu Asp Asp Asn Ile Arg Ser Leu Leu
        355                 360                 365             
Lys Pro Leu Glu Leu Glu Leu Gln Lys Thr Val His Thr Tyr Cys Gly
    370                 375                 380                 
Lys Ile Tyr Lys Ile Phe Ile Lys Gln Leu Ala Lys Ser Val Arg Asp
385                 390                 395                 400 
Arg Tyr Ala Arg Ser Pro Lys Glu Lys
                405                 


<210> 6644
<211> 977
<212> PRT
<213> Homo sapiens

<400> 6644
Met Arg Thr Ala Gly Arg Asp Pro Val Pro Arg Arg Ser Pro Arg Trp
 1               5                  10                  15      
Arg Arg Ala Val Pro Leu Cys Glu Thr Ser Ala Gly Arg Arg Val Thr
            20                  25                  30          
Gln Leu Arg Gly Asp Asp Leu Arg Arg Pro Ala Thr Met Lys Gly Lys
        35                  40                  45              
Glu Arg Ser Pro Val Lys Ala Lys Arg Ser Arg Gly Gly Glu Asp Ser
    50                  55                  60                  
Thr Ser Arg Gly Glu Arg Ser Lys Lys Leu Gly Gly Ser Gly Gly Ser
65                  70                  75                  80  
Asn Gly Ser Ser Ser Gly Lys Thr Asp Ser Gly Gly Gly Ser Arg Arg
                85                  90                  95      
Ser Leu His Leu Asp Lys Ser Ser Ser Arg Gly Gly Ser Arg Glu Tyr
            100                 105                 110         
Asp Thr Gly Gly Gly Ser Ser Ser Ser Arg Leu His Ser Tyr Ser Ser
        115                 120                 125             
Pro Ser Thr Lys Asn Ser Ser Gly Gly Gly Glu Ser Arg Ser Ser Ser
    130                 135                 140                 
Arg Gly Gly Gly Gly Glu Ser Arg Ser Ser Gly Ala Ala Ser Ser Ala
145                 150                 155                 160 
Pro Gly Gly Gly Asp Gly Ala Glu Tyr Lys Thr Leu Lys Ile Ser Glu
                165                 170                 175     
Leu Gly Ser Gln Leu Ser Asp Glu Ala Val Glu Asp Gly Leu Phe His
            180                 185                 190         
Glu Phe Lys Arg Phe Gly Asp Val Ser Val Lys Ile Ser His Leu Ser
        195                 200                 205             
Gly Ser Gly Ser Gly Asp Glu Arg Val Ala Phe Val Asn Phe Arg Arg
    210                 215                 220                 
Pro Glu Asp Ala Arg Ala Ala Lys His Ala Arg Gly Arg Leu Val Leu
225                 230                 235                 240 
Tyr Asp Arg Pro Leu Lys Ile Glu Ala Val Tyr Val Ser Arg Arg Arg
                245                 250                 255     
Ser Arg Ser Pro Leu Asp Lys Asp Thr Tyr Pro Pro Ser Ala Ser Val
            260                 265                 270         
Val Gly Ala Ser Val Gly Gly His Arg His Pro Pro Gly Gly Gly Gly
        275                 280                 285             
Gly Gln Arg Ser Leu Ser Pro Gly Gly Ala Ala Leu Gly Tyr Arg Asp
    290                 295                 300                 
Tyr Arg Leu Gln Gln Leu Ala Leu Gly Arg Leu Pro Pro Pro Pro Pro
305                 310                 315                 320 
Pro Pro Leu Pro Arg Asp Leu Glu Arg Glu Arg Asp Tyr Pro Phe Tyr
                325                 330                 335     
Glu Arg Val Arg Pro Ala Tyr Ser Leu Glu Pro Arg Val Gly Ala Gly
            340                 345                 350         
Ala Gly Ala Ala Pro Phe Arg Glu Val Asp Glu Ile Ser Pro Glu Asp
        355                 360                 365             
Asp Gln Arg Ala Asn Arg Thr Leu Phe Leu Gly Asn Leu Asp Ile Thr
    370                 375                 380                 
Val Thr Glu Ser Asp Leu Arg Arg Ala Phe Asp Arg Phe Gly Val Ile
385                 390                 395                 400 
Thr Glu Val Asp Ile Lys Arg Pro Ser Arg Gly Gln Thr Ser Thr Tyr
                405                 410                 415     
Gly Phe Leu Lys Phe Glu Asn Leu Asp Met Ser His Arg Ala Lys Leu
            420                 425                 430         
Ala Met Ser Gly Lys Ile Ile Ile Arg Asn Pro Ile Lys Ile Gly Tyr
        435                 440                 445             
Gly Lys Ala Thr Pro Thr Thr Arg Leu Trp Val Gly Gly Leu Gly Pro
    450                 455                 460                 
Trp Val Pro Leu Ala Ala Leu Ala Arg Glu Phe Asp Arg Phe Gly Thr
465                 470                 475                 480 
Ile Arg Thr Ile Asp Tyr Arg Lys Gly Asp Ser Trp Ala Tyr Ile Gln
                485                 490                 495     
Tyr Glu Ser Leu Asp Ala Ala His Ala Ala Trp Thr His Met Arg Gly
            500                 505                 510         
Phe Pro Leu Gly Gly Pro Asp Arg Arg Leu Arg Val Asp Phe Ala Asp
        515                 520                 525             
Thr Glu His Arg Tyr Gln Gln Gln Tyr Leu Gln Pro Leu Pro Leu Thr
    530                 535                 540                 
His Tyr Glu Leu Val Thr Asp Ala Phe Gly His Arg Ala Pro Asp Pro
545                 550                 555                 560 
Leu Arg Gly Ala Arg Asp Arg Thr Pro Pro Leu Leu Tyr Arg Asp Arg
                565                 570                 575     
Asp Arg Asp Leu Tyr Pro Asp Ser Asp Trp Val Pro Pro Pro Pro Pro
            580                 585                 590         
Val Arg Glu Arg Ser Thr Arg Thr Ala Ala Thr Ser Val Pro Ala Tyr
        595                 600                 605             
Glu Pro Leu Asp Ser Leu Asp Arg Arg Arg Asp Gly Trp Ser Leu Asp
    610                 615                 620                 
Arg Asp Arg Gly Asp Arg Asp Leu Pro Ser Ser Arg Asp Gln Pro Arg
625                 630                 635                 640 
Lys Arg Arg Leu Pro Glu Glu Ser Gly Gly Arg His Leu Asp Arg Ser
                645                 650                 655     
Pro Glu Ser Asp Arg Pro Arg Lys Arg His Cys Ala Pro Ser Pro Asp
            660                 665                 670         
Arg Ser Pro Glu Leu Ser Ser Ser Arg Asp Arg Tyr Asn Ser Asp Asn
        675                 680                 685             
Asp Arg Ser Ser Arg Leu Leu Leu Glu Arg Pro Ser Pro Ile Arg Asp
    690                 695                 700                 
Arg Arg Gly Ser Leu Glu Lys Ser Gln Gly Asp Lys Arg Asp Arg Lys
705                 710                 715                 720 
Asn Ser Ala Ser Ala Glu Arg Asp Arg Lys His Arg Thr Thr Ala Pro
                725                 730                 735     
Thr Glu Gly Lys Ser Pro Leu Lys Lys Glu Asp Arg Ser Asp Gly Ser
            740                 745                 750         
Ala Pro Ser Thr Ser Thr Ala Ser Ser Lys Leu Lys Ser Pro Ser Gln
        755                 760                 765             
Lys Gln Asp Gly Gly Thr Ala Pro Val Ala Ser Ala Ser Pro Lys Leu
    770                 775                 780                 
Cys Leu Ala Trp Gln Gly Met Leu Leu Leu Lys Asn Ser Asn Phe Pro
785                 790                 795                 800 
Ser Asn Met His Leu Leu Gln Gly Asp Leu Gln Val Ala Ser Ser Leu
                805                 810                 815     
Leu Val Glu Gly Ser Thr Gly Gly Lys Val Ala Gln Leu Lys Ile Thr
            820                 825                 830         
Gln Arg Leu Arg Leu Asp Gln Pro Lys Leu Asp Glu Val Thr Arg Arg
        835                 840                 845             
Ile Lys Val Ala Gly Pro Asn Gly Tyr Ala Ile Leu Leu Ala Val Pro
    850                 855                 860                 
Gly Ser Ser Asp Ser Arg Ser Ser Ser Ser Ser Ala Ala Ser Asp Thr
865                 870                 875                 880 
Ala Thr Ser Thr Gln Arg Pro Leu Arg Asn Leu Val Ser Tyr Leu Lys
                885                 890                 895     
Gln Lys Gln Ala Ala Gly Val Ile Ser Leu Pro Val Gly Gly Asn Lys
            900                 905                 910         
Asp Lys Glu Asn Thr Gly Val Leu His Ala Phe Pro Pro Cys Glu Phe
        915                 920                 925             
Ser Gln Gln Phe Leu Asp Ser Pro Ala Lys Ala Leu Ala Lys Ser Glu
    930                 935                 940                 
Glu Asp Tyr Leu Val Met Ile Ile Val Arg Gly Phe Gly Phe Gln Ile
945                 950                 955                 960 
Gly Val Arg Tyr Glu Asn Lys Lys Arg Glu Asn Leu Ala Leu Thr Leu
                965                 970                 975     
Leu
    


<210> 6645
<211> 969
<212> PRT
<213> Homo sapiens

<400> 6645
Met Arg Thr Ala Gly Arg Asp Pro Val Pro Arg Arg Ser Pro Arg Trp
 1               5                  10                  15      
Arg Arg Ala Val Pro Leu Cys Glu Thr Ser Ala Gly Arg Arg Val Thr
            20                  25                  30          
Gln Leu Arg Gly Asp Asp Leu Arg Arg Pro Ala Thr Met Lys Gly Lys
        35                  40                  45              
Glu Arg Ser Pro Val Lys Ala Lys Arg Ser Arg Gly Gly Glu Asp Ser
    50                  55                  60                  
Thr Ser Arg Gly Glu Arg Ser Lys Lys Leu Gly Gly Ser Gly Gly Ser
65                  70                  75                  80  
Asn Gly Ser Ser Ser Gly Lys Thr Asp Ser Gly Gly Gly Ser Arg Arg
                85                  90                  95      
Ser Leu His Leu Asp Lys Ser Ser Ser Arg Gly Gly Ser Arg Glu Tyr
            100                 105                 110         
Asp Thr Gly Gly Gly Ser Ser Ser Ser Arg Leu His Ser Tyr Ser Ser
        115                 120                 125             
Pro Ser Thr Lys Asn Ser Ser Gly Gly Gly Glu Ser Arg Ser Ser Ser
    130                 135                 140                 
Arg Gly Gly Gly Gly Glu Ser Arg Ser Ser Gly Ala Ala Ser Ser Ala
145                 150                 155                 160 
Pro Gly Gly Gly Asp Gly Ala Glu Tyr Lys Thr Leu Lys Ile Ser Glu
                165                 170                 175     
Leu Gly Ser Gln Leu Ser Asp Glu Ala Val Glu Asp Gly Leu Phe His
            180                 185                 190         
Glu Phe Lys Arg Phe Gly Asp Val Ser Val Lys Ile Ser His Leu Ser
        195                 200                 205             
Gly Ser Gly Ser Gly Asp Glu Arg Val Ala Phe Val Asn Phe Arg Arg
    210                 215                 220                 
Pro Glu Asp Ala Arg Ala Ala Lys His Ala Arg Gly Arg Leu Val Leu
225                 230                 235                 240 
Tyr Asp Arg Pro Leu Lys Ile Glu Ala Val Tyr Val Ser Arg Arg Arg
                245                 250                 255     
Ser Arg Ser Pro Leu Asp Lys Asp Thr Tyr Pro Pro Ser Ala Ser Val
            260                 265                 270         
Val Gly Ala Ser Val Gly Gly His Arg His Pro Pro Gly Gly Gly Gly
        275                 280                 285             
Gly Gln Arg Ser Leu Ser Pro Gly Gly Ala Ala Leu Gly Tyr Arg Asp
    290                 295                 300                 
Tyr Arg Leu Gln Gln Leu Ala Leu Gly Arg Leu Pro Pro Pro Pro Pro
305                 310                 315                 320 
Pro Pro Leu Pro Arg Asp Leu Glu Arg Glu Arg Asp Tyr Pro Phe Tyr
                325                 330                 335     
Glu Arg Val Arg Pro Ala Tyr Ser Leu Glu Pro Arg Val Gly Ala Gly
            340                 345                 350         
Ala Gly Ala Ala Pro Phe Arg Glu Val Asp Glu Ile Ser Pro Glu Asp
        355                 360                 365             
Asp Gln Arg Ala Asn Arg Thr Leu Phe Leu Gly Asn Leu Asp Ile Thr
    370                 375                 380                 
Val Thr Glu Ser Asp Leu Arg Arg Ala Phe Asp Arg Phe Gly Val Ile
385                 390                 395                 400 
Thr Glu Val Asp Ile Lys Arg Pro Ser Arg Gly Gln Thr Ser Thr Tyr
                405                 410                 415     
Gly Phe Leu Lys Phe Glu Asn Leu Asp Met Ser His Arg Ala Lys Leu
            420                 425                 430         
Ala Met Ser Gly Lys Ile Ile Ile Arg Asn Pro Ile Lys Ile Gly Tyr
        435                 440                 445             
Gly Lys Ala Thr Pro Thr Thr Arg Leu Trp Val Gly Gly Leu Gly Pro
    450                 455                 460                 
Trp Val Pro Leu Ala Ala Leu Ala Arg Glu Phe Asp Arg Phe Gly Thr
465                 470                 475                 480 
Ile Arg Thr Ile Asp Tyr Arg Lys Gly Asp Ser Trp Ala Tyr Ile Gln
                485                 490                 495     
Tyr Glu Ser Leu Asp Ala Ala His Ala Ala Trp Thr His Met Arg Gly
            500                 505                 510         
Phe Pro Leu Gly Gly Pro Asp Arg Arg Leu Arg Val Asp Phe Ala Asp
        515                 520                 525             
Thr Glu His Arg Tyr Gln Gln Gln Tyr Leu Gln Pro Leu Pro Leu Thr
    530                 535                 540                 
His Tyr Glu Leu Val Thr Asp Ala Phe Gly His Arg Ala Pro Asp Pro
545                 550                 555                 560 
Leu Arg Gly Ala Arg Asp Arg Thr Pro Pro Leu Leu Tyr Arg Asp Arg
                565                 570                 575     
Asp Arg Asp Leu Tyr Pro Asp Ser Asp Trp Val Pro Pro Pro Pro Pro
            580                 585                 590         
Val Arg Glu Arg Ser Thr Arg Thr Ala Ala Thr Ser Val Pro Ala Tyr
        595                 600                 605             
Glu Pro Leu Asp Ser Leu Asp Arg Arg Arg Asp Gly Trp Ser Leu Asp
    610                 615                 620                 
Arg Asp Arg Gly Asp Arg Asp Leu Pro Ser Ser Arg Asp Gln Pro Arg
625                 630                 635                 640 
Lys Arg Arg Leu Pro Glu Glu Ser Gly Gly Arg His Leu Asp Arg Ser
                645                 650                 655     
Pro Glu Ser Asp Arg Pro Arg Lys Arg His Cys Ala Pro Ser Pro Asp
            660                 665                 670         
Arg Ser Pro Glu Leu Ser Ser Ser Arg Asp Arg Tyr Asn Ser Asp Asn
        675                 680                 685             
Asp Arg Ser Ser Arg Leu Leu Leu Glu Arg Pro Ser Pro Ile Arg Asp
    690                 695                 700                 
Arg Arg Gly Ser Leu Glu Lys Ser Gln Gly Asp Lys Arg Asp Arg Lys
705                 710                 715                 720 
Asn Ser Ala Ser Ala Glu Arg Asp Arg Lys His Arg Thr Thr Ala Pro
                725                 730                 735     
Thr Glu Gly Lys Ser Pro Leu Lys Lys Glu Asp Arg Ser Asp Gly Ser
            740                 745                 750         
Ala Pro Ser Thr Ser Thr Ala Ser Ser Lys Leu Lys Ser Pro Ser Gln
        755                 760                 765             
Lys Gln Asp Gly Gly Thr Ala Pro Val Ala Ser Ala Ser Pro Lys Leu
    770                 775                 780                 
Cys Leu Ala Trp Gln Gly Met Leu Leu Leu Lys Asn Ser Asn Phe Pro
785                 790                 795                 800 
Ser Asn Met His Leu Leu Gln Gly Asp Leu Gln Val Ala Ser Ser Leu
                805                 810                 815     
Leu Val Glu Gly Ser Thr Gly Gly Lys Val Ala Gln Leu Lys Ile Thr
            820                 825                 830         
Gln Arg Leu Arg Leu Asp Gln Pro Lys Leu Asp Glu Val Thr Arg Arg
        835                 840                 845             
Ile Lys Val Ala Gly Pro Asn Gly Tyr Ala Ile Leu Leu Ala Val Pro
    850                 855                 860                 
Gly Ser Ser Asp Ser Arg Ser Ser Ser Ser Ser Ala Ala Ser Asp Thr
865                 870                 875                 880 
Ala Thr Ser Thr Gln Arg Pro Leu Arg Asn Leu Val Ser Tyr Leu Lys
                885                 890                 895     
Gln Lys Gln Ala Ala Gly Val Ile Ser Leu Pro Val Gly Gly Asn Lys
            900                 905                 910         
Asp Lys Glu Asn Thr Gly Val Leu His Ala Phe Pro Pro Cys Glu Phe
        915                 920                 925             
Ser Gln Gln Phe Leu Asp Ser Pro Ala Lys Ala Leu Ala Lys Ser Glu
    930                 935                 940                 
Glu Asp Tyr Leu Val Met Ile Ile Val Arg Ala Lys Leu Val Glu Gln
945                 950                 955                 960 
Arg Met Lys Ile Trp Asn Ser Lys Leu
                965                 


<210> 6646
<211> 957
<212> PRT
<213> Homo sapiens

<400> 6646
Met Arg Thr Ala Gly Arg Asp Pro Val Pro Arg Arg Ser Pro Arg Trp
 1               5                  10                  15      
Arg Arg Ala Val Pro Leu Cys Glu Thr Ser Ala Gly Arg Arg Val Thr
            20                  25                  30          
Gln Leu Arg Gly Asp Asp Leu Arg Arg Pro Ala Thr Met Lys Gly Lys
        35                  40                  45              
Glu Arg Ser Pro Val Lys Ala Lys Arg Ser Arg Gly Gly Glu Asp Ser
    50                  55                  60                  
Thr Ser Arg Gly Glu Arg Ser Lys Lys Leu Gly Gly Ser Gly Gly Ser
65                  70                  75                  80  
Asn Gly Ser Ser Ser Gly Lys Thr Asp Ser Gly Gly Gly Ser Arg Arg
                85                  90                  95      
Ser Leu His Leu Asp Lys Ser Ser Ser Arg Gly Gly Ser Arg Glu Tyr
            100                 105                 110         
Asp Thr Gly Gly Gly Ser Ser Ser Ser Arg Leu His Ser Tyr Ser Ser
        115                 120                 125             
Pro Ser Thr Lys Asn Ser Ser Gly Gly Gly Glu Ser Arg Ser Ser Ser
    130                 135                 140                 
Arg Gly Gly Gly Gly Glu Ser Arg Ser Ser Gly Ala Ala Ser Ser Ala
145                 150                 155                 160 
Pro Gly Gly Gly Asp Gly Ala Glu Tyr Lys Thr Leu Lys Ile Ser Glu
                165                 170                 175     
Leu Gly Ser Gln Leu Ser Asp Glu Ala Val Glu Asp Gly Leu Phe His
            180                 185                 190         
Glu Phe Lys Arg Phe Gly Asp Val Ser Val Lys Ile Ser His Leu Ser
        195                 200                 205             
Gly Ser Gly Ser Gly Asp Glu Arg Val Ala Phe Val Asn Phe Arg Arg
    210                 215                 220                 
Pro Glu Asp Ala Arg Ala Ala Lys His Ala Arg Gly Arg Leu Val Leu
225                 230                 235                 240 
Tyr Asp Arg Pro Leu Lys Ile Glu Ala Val Tyr Val Ser Arg Arg Arg
                245                 250                 255     
Ser Arg Ser Pro Leu Asp Lys Asp Thr Tyr Pro Pro Ser Ala Ser Val
            260                 265                 270         
Val Gly Ala Ser Val Gly Gly His Arg His Pro Pro Gly Gly Gly Gly
        275                 280                 285             
Gly Gln Arg Ser Leu Ser Pro Gly Gly Ala Ala Leu Gly Tyr Arg Asp
    290                 295                 300                 
Tyr Arg Leu Gln Gln Leu Ala Leu Gly Arg Leu Pro Pro Pro Pro Pro
305                 310                 315                 320 
Pro Pro Leu Pro Arg Asp Leu Glu Arg Glu Arg Asp Tyr Pro Phe Tyr
                325                 330                 335     
Glu Arg Val Arg Pro Ala Tyr Ser Leu Glu Pro Arg Val Gly Ala Gly
            340                 345                 350         
Ala Gly Ala Ala Pro Phe Arg Glu Val Asp Glu Ile Ser Pro Glu Asp
        355                 360                 365             
Asp Gln Arg Ala Asn Arg Thr Leu Phe Leu Gly Asn Leu Asp Ile Thr
    370                 375                 380                 
Val Thr Glu Ser Asp Leu Arg Arg Ala Phe Asp Arg Phe Gly Val Ile
385                 390                 395                 400 
Thr Glu Val Asp Ile Lys Arg Pro Ser Arg Gly Gln Thr Ser Thr Tyr
                405                 410                 415     
Gly Phe Leu Lys Phe Glu Asn Leu Asp Met Ser His Arg Ala Lys Leu
            420                 425                 430         
Ala Met Ser Gly Lys Ile Ile Ile Arg Asn Pro Ile Lys Ile Gly Tyr
        435                 440                 445             
Gly Lys Ala Thr Pro Thr Thr Arg Leu Trp Val Gly Gly Leu Gly Pro
    450                 455                 460                 
Trp Val Pro Leu Ala Ala Leu Ala Arg Glu Phe Asp Arg Phe Gly Thr
465                 470                 475                 480 
Ile Arg Thr Ile Asp Tyr Arg Lys Gly Asp Ser Trp Ala Tyr Ile Gln
                485                 490                 495     
Tyr Glu Ser Leu Asp Ala Ala His Ala Ala Trp Thr His Met Arg Gly
            500                 505                 510         
Phe Pro Leu Gly Gly Pro Asp Arg Arg Leu Arg Val Asp Phe Ala Asp
        515                 520                 525             
Thr Glu His Arg Tyr Gln Gln Gln Tyr Leu Gln Pro Leu Pro Leu Thr
    530                 535                 540                 
His Tyr Glu Leu Val Thr Asp Ala Phe Gly His Arg Ala Pro Asp Pro
545                 550                 555                 560 
Leu Arg Gly Ala Arg Asp Arg Thr Pro Pro Leu Leu Tyr Arg Asp Arg
                565                 570                 575     
Asp Arg Asp Leu Tyr Pro Asp Ser Asp Trp Val Pro Pro Pro Pro Pro
            580                 585                 590         
Val Arg Glu Arg Ser Thr Arg Thr Ala Ala Thr Ser Val Pro Ala Tyr
        595                 600                 605             
Glu Pro Leu Asp Ser Leu Asp Arg Arg Arg Asp Gly Trp Ser Leu Asp
    610                 615                 620                 
Arg Asp Arg Gly Asp Arg Asp Leu Pro Ser Ser Arg Asp Gln Pro Arg
625                 630                 635                 640 
Lys Arg Arg Leu Pro Glu Glu Ser Gly Gly Arg His Leu Asp Arg Ser
                645                 650                 655     
Pro Glu Ser Asp Arg Pro Arg Lys Arg His Cys Ala Pro Ser Pro Asp
            660                 665                 670         
Arg Ser Pro Glu Leu Ser Ser Ser Arg Asp Arg Tyr Asn Ser Asp Asn
        675                 680                 685             
Asp Arg Ser Ser Arg Leu Leu Leu Glu Arg Pro Ser Pro Ile Arg Asp
    690                 695                 700                 
Arg Arg Gly Ser Leu Glu Lys Ser Gln Gly Asp Lys Arg Asp Arg Lys
705                 710                 715                 720 
Asn Ser Ala Ser Ala Glu Arg Asp Arg Lys His Arg Thr Thr Ala Pro
                725                 730                 735     
Thr Glu Gly Lys Ser Pro Leu Lys Lys Glu Asp Arg Ser Asp Gly Ser
            740                 745                 750         
Ala Pro Ser Thr Ser Thr Ala Ser Ser Lys Leu Lys Ser Pro Ser Gln
        755                 760                 765             
Lys Gln Asp Gly Gly Thr Ala Pro Val Ala Ser Ala Ser Pro Lys Leu
    770                 775                 780                 
Cys Leu Ala Trp Gln Gly Met Leu Leu Leu Lys Asn Ser Asn Phe Pro
785                 790                 795                 800 
Ser Asn Met His Leu Leu Gln Gly Asp Leu Gln Val Ala Ser Ser Leu
                805                 810                 815     
Leu Val Glu Gly Ser Thr Gly Gly Lys Val Ala Gln Leu Lys Ile Thr
            820                 825                 830         
Gln Arg Leu Arg Leu Asp Gln Pro Lys Leu Asp Glu Val Thr Arg Arg
        835                 840                 845             
Ile Lys Val Ala Gly Pro Asn Gly Tyr Ala Ile Leu Leu Ala Val Pro
    850                 855                 860                 
Gly Ser Ser Asp Ser Arg Ser Ser Ser Ser Ser Ala Ala Ser Asp Thr
865                 870                 875                 880 
Ala Thr Ser Thr Gln Arg Pro Leu Arg Asn Leu Val Ser Tyr Leu Lys
                885                 890                 895     
Gln Lys Gln Ala Ala Gly Val Ile Ser Leu Pro Val Gly Gly Asn Lys
            900                 905                 910         
Asp Lys Glu Asn Thr Gly Val Leu His Ala Phe Pro Pro Cys Glu Phe
        915                 920                 925             
Ser Gln Gln Phe Leu Asp Ser Pro Ala Lys Ala Leu Ala Lys Ser Glu
    930                 935                 940                 
Glu Asp Tyr Leu Val Met Ile Ile Val Arg Gly Ala Ser
945                 950                 955         


<210> 6647
<211> 1026
<212> PRT
<213> Homo sapiens

<400> 6647
Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys
 1               5                  10                  15      
Leu Ser Glu Ser Val Asp Tyr Gly Pro Val Phe Val Gln Glu Pro Asp
            20                  25                  30          
Asp Ile Ile Phe Pro Thr Asp Ser Asp Glu Lys Lys Val Ala Leu Asn
        35                  40                  45              
Cys Glu Val Arg Gly Asn Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn
    50                  55                  60                  
Gly Thr Glu Ile Asp Leu Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp
65                  70                  75                  80  
Gly Thr Phe Ile Ile Ser Asn Pro Ser Glu Ala Lys Asp Ser Gly His
                85                  90                  95      
Tyr Gln Cys Leu Ala Thr Asn Thr Val Gly Ser Ile Leu Ser Arg Glu
            100                 105                 110         
Ala Thr Leu Gln Phe Ala Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg
        115                 120                 125             
Ser Ala Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Met Cys Ser
    130                 135                 140                 
Pro Pro Pro His Ser Pro Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu
145                 150                 155                 160 
Phe Pro Ser Phe Val Ala Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu
                165                 170                 175     
Thr Gly Asn Leu Tyr Ile Ser Lys Val Gln Thr Ser Asp Val Gly Ser
            180                 185                 190         
Tyr Ile Cys Leu Val Lys Asn Thr Val Thr Asn Ala Arg Val Leu Ser
        195                 200                 205             
Pro Pro Thr Pro Leu Thr Leu Arg Asn Asp Gly Val Met Gly Glu Tyr
    210                 215                 220                 
Glu Pro Lys Ile Glu Val His Phe Pro Phe Thr Val Thr Ala Ala Lys
225                 230                 235                 240 
Gly Thr Thr Val Lys Met Glu Cys Phe Ala Leu Gly Asn Pro Val Pro
                245                 250                 255     
Thr Ile Thr Trp Met Lys Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg
            260                 265                 270         
Leu Arg Lys Ser Gln Ala Val Leu Glu Ile Pro Asn Val Gln Leu Asp
        275                 280                 285             
Asp Ala Gly Ile Tyr Glu Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn
    290                 295                 300                 
Ser Phe Arg Gly Gln Leu Gln Val Tyr Thr Tyr Pro His Trp Val Glu
305                 310                 315                 320 
Lys Leu Asn Asp Thr Gln Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu
                325                 330                 335     
Cys Lys Ala Thr Gly Lys Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn
            340                 345                 350         
Gly Val Pro Leu Ser Pro Gln Ser Arg Val Glu Met Val Asn Gly Val
        355                 360                 365             
Leu Met Ile His Asn Val Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys
    370                 375                 380                 
Leu Ala Glu Asn Lys Tyr Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys
385                 390                 395                 400 
Ile Leu Ala Ser Ala Pro Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr
                405                 410                 415     
Ile Ile Val Thr Lys Asp Gln Glu Val Val Ile Glu Cys Lys Pro Gln
            420                 425                 430         
Gly Ser Pro Lys Pro Thr Ile Ser Trp Lys Lys Gly Asp Arg Ala Val
        435                 440                 445             
Arg Glu Asn Lys Arg Ile Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile
    450                 455                 460                 
Leu Asn Ala Ser Lys Ser Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu
465                 470                 475                 480 
Asn Val Phe Gly Ser Ala Glu Ile Ile Ala Ser Leu Ser Val Lys Glu
                485                 490                 495     
Pro Thr Arg Ile Glu Leu Thr Pro Lys Arg Thr Glu Leu Thr Val Gly
            500                 505                 510         
Glu Ser Ile Val Leu Asn Cys Lys Ala Ile His Asp Ala Ser Leu Asp
        515                 520                 525             
Val Thr Phe Tyr Trp Thr Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu
    530                 535                 540                 
Glu Gly Gly His Phe Glu Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp
545                 550                 555                 560 
Leu Met Ile Arg Asn Ile Leu Leu Met His Ala Gly Arg Tyr Gly Cys
                565                 570                 575     
Arg Val Gln Thr Thr Ala Asp Ser Val Ser Asp Glu Ala Glu Leu Leu
            580                 585                 590         
Val Arg Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Val Glu Glu Ile
        595                 600                 605             
Thr Glu Ser Thr Ala Thr Leu Ser Trp Ser Pro Ala Ala Asp Asn His
    610                 615                 620                 
Ser Pro Ile Ser Ser Tyr Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu
625                 630                 635                 640 
Gly Trp Gln Thr Val Lys Thr Val Pro Glu Ile Ile Thr Gly Asp Met
                645                 650                 655     
Glu Ser Ala Met Ala Val Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe
            660                 665                 670         
Arg Val Val Ala Thr Asn Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro
        675                 680                 685             
Ser Arg Met Ile Arg Thr Asn Glu Ala Val Pro Lys Thr Ala Pro Thr
    690                 695                 700                 
Asn Val Ser Gly Arg Ser Gly Arg Arg His Glu Leu Val Ile Ala Trp
705                 710                 715                 720 
Glu Pro Val Ser Glu Glu Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile
                725                 730                 735     
Val Ala Phe Arg Pro Asn Gly Thr Arg Gly Trp Lys Glu Lys Met Val
            740                 745                 750         
Thr Ser Ser Glu Ala Ser Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro
        755                 760                 765             
Pro Leu Thr Pro Phe Glu Val Lys Val Gly Val Tyr Asn Asn Lys Gly
    770                 775                 780                 
Asp Gly Pro Phe Ser Gln Ile Val Val Ile Cys Ser Ala Glu Gly Glu
785                 790                 795                 800 
Pro Ser Ala Ala Pro Thr Asp Val Lys Ala Thr Ser Val Ser Val Ser
                805                 810                 815     
Glu Ile Leu Val Ala Trp Lys His Ile Lys Glu Ser Leu Gly Arg Pro
            820                 825                 830         
Gln Gly Phe Glu Val Gly Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr
        835                 840                 845             
Ala Glu Thr Val Lys Thr Arg Gly Asn Glu Ser Phe Val Ile Leu Thr
    850                 855                 860                 
Gly Leu Glu Gly Asn Thr Leu Tyr His Phe Thr Val Arg Ala Tyr Asn
865                 870                 875                 880 
Gly Ala Gly Tyr Gly Pro Pro Ser Ser Glu Val Ser Ala Thr Thr Lys
                885                 890                 895     
Lys Ser Pro Pro Ser Gln Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln
            900                 905                 910         
Gly Ser Gln Val Ser Leu Gly Trp Glu Pro Val Ile Pro Leu Ala Asn
        915                 920                 925             
Glu Ser Glu Val Val Gly Tyr Lys Val Phe Tyr Arg Gln Glu Gly His
    930                 935                 940                 
Ser Asn Ser Gln Val Ile Glu Thr Gln Lys Leu Gln Ala Val Val Pro
945                 950                 955                 960 
Leu Pro Asp Ala Gly Val Tyr Ile Ile Glu Val Arg Ala Tyr Ser Glu
                965                 970                 975     
Gly Gly Asp Gly Thr Ala Ser Ser Gln Ile Arg Val Pro Ser Tyr Ser
            980                 985                 990         
Gly Gly Lys Ile Thr Ser Ala Gln Ser Thr Leu His Ser Leu Ser Thr
        995                 1000                1005            
Ser Ser Ser Ser Val Thr Leu Leu Leu Ala Leu Met Ile Pro Ser Thr
    1010                1015                1020                
Ser Trp
1025    


<210> 6648
<211> 1100
<212> PRT
<213> Homo sapiens

<400> 6648
Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys
 1               5                  10                  15      
Leu Ser Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala
            20                  25                  30          
Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser
        35                  40                  45              
Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala
    50                  55                  60                  
Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile
65                  70                  75                  80  
Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp
                85                  90                  95      
Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr
            100                 105                 110         
Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn
        115                 120                 125             
Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu
    130                 135                 140                 
Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser
145                 150                 155                 160 
Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr
                165                 170                 175     
Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala
            180                 185                 190         
Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg
        195                 200                 205             
Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro
    210                 215                 220                 
Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala
225                 230                 235                 240 
Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile
                245                 250                 255     
Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys
            260                 265                 270         
Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr
        275                 280                 285             
Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val
    290                 295                 300                 
His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met
305                 310                 315                 320 
Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys
                325                 330                 335     
Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala
            340                 345                 350         
Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu
        355                 360                 365             
Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu
    370                 375                 380                 
Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln
385                 390                 395                 400 
Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys
                405                 410                 415     
Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro
            420                 425                 430         
Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val
        435                 440                 445             
Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr
    450                 455                 460                 
Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro
465                 470                 475                 480 
Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp
                485                 490                 495     
Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr
            500                 505                 510         
Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile
        515                 520                 525             
Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser
    530                 535                 540                 
Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala
545                 550                 555                 560 
Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu
                565                 570                 575     
Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn
            580                 585                 590         
Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr
        595                 600                 605             
Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu
    610                 615                 620                 
Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile
625                 630                 635                 640 
Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala
                645                 650                 655     
Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly
            660                 665                 670         
Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr
        675                 680                 685             
Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr
    690                 695                 700                 
Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys
705                 710                 715                 720 
Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val
                725                 730                 735     
Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn
            740                 745                 750         
Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr
        755                 760                 765             
Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser
    770                 775                 780                 
Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu
785                 790                 795                 800 
Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn
                805                 810                 815     
Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser
            820                 825                 830         
Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu
        835                 840                 845             
Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln
    850                 855                 860                 
Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr
865                 870                 875                 880 
Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp
                885                 890                 895     
Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val Gly
            900                 905                 910         
Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val Lys Thr
        915                 920                 925             
Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly Asn Thr
    930                 935                 940                 
Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr Gly Pro
945                 950                 955                 960 
Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro Ser Gln
                965                 970                 975     
Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val Ser Leu
            980                 985                 990         
Gly Trp Glu Pro Val Ile Pro Leu Ala Asn Glu Ser Glu Val Val Gly
        995                 1000                1005            
Tyr Lys Val Phe Tyr Arg Gln Glu Gly His Ser Asn Ser Gln Val Ile
    1010                1015                1020                
Glu Thr Gln Lys Leu Gln Ala Val Val Pro Leu Pro Asp Ala Gly Val
1025                1030                1035                1040
Tyr Ile Ile Glu Val Arg Ala Tyr Ser Glu Gly Gly Asp Gly Thr Ala
                1045                1050                1055    
Ser Ser Gln Ile Arg Val Pro Ser Tyr Ser Gly Gly Lys Ile Thr Ser
            1060                1065                1070        
Ala Gln Ser Thr Leu His Ser Leu Ser Thr Ser Ser Ser Ser Val Thr
        1075                1080                1085            
Leu Leu Leu Ala Leu Met Ile Pro Ser Thr Ser Trp
    1090                1095                1100


<210> 6649
<211> 1029
<212> PRT
<213> Homo sapiens

<400> 6649
Met Gln Thr Asn Glu Gly Glu Val Ser Glu Glu Ser Ser Ser Lys Val
 1               5                  10                  15      
Glu Gln Glu Asp Phe Val Met Glu Gly His Gly Lys Thr Pro Pro Pro
            20                  25                  30          
Gly Glu Glu Ser Lys Gln Glu Lys Glu Gln Glu Arg Glu Glu Gln Leu
        35                  40                  45              
Met Glu Asp Lys Lys Arg Lys Lys Glu Asp Lys Lys Lys Lys Glu Ala
    50                  55                  60                  
Thr Gln Lys Val Thr Glu Gln Lys Thr Lys Val Pro Glu Val Thr Lys
65                  70                  75                  80  
Pro Ser Leu Ser Gln Pro Thr Ala Ala Ser Pro Ile Gly Ser Ser Pro
                85                  90                  95      
Ser Pro Pro Val Asn Gly Gly Asn Asn Ala Lys Arg Val Ala Val Pro
            100                 105                 110         
Asn Gly Gln Pro Pro Ser Ala Ala Arg Tyr Met Pro Arg Glu Val Pro
        115                 120                 125             
Pro Arg Phe Arg Cys Gln Gln Asp His Lys Val Leu Leu Lys Arg Gly
    130                 135                 140                 
Gln Pro Pro Pro Pro Ser Cys Met Leu Leu Gly Gly Gly Ala Gly Pro
145                 150                 155                 160 
Pro Pro Cys Thr Ala Pro Gly Ala Asn Pro Asn Asn Ala Gln Val Thr
                165                 170                 175     
Gly Ala Leu Leu Gln Ser Glu Ser Gly Thr Ala Pro Val Trp Ser Lys
            180                 185                 190         
Ser Thr Pro Pro Ala Pro Asp Asn Gly Thr Ser Ala Trp Gly Glu Pro
        195                 200                 205             
Asn Glu Ser Ser Pro Gly Trp Gly Glu Met Asp Asp Thr Gly Ala Ser
    210                 215                 220                 
Thr Thr Gly Trp Gly Asn Thr Pro Ala Asn Ala Pro Asn Ala Met Lys
225                 230                 235                 240 
Pro Asn Ser Lys Ser Met Gln Asp Gly Trp Gly Glu Ser Asp Gly Pro
                245                 250                 255     
Val Thr Gly Ala Arg His Pro Ser Trp Glu Glu Glu Glu Asp Gly Gly
            260                 265                 270         
Val Trp Asn Thr Thr Gly Ser Gln Gly Ser Ala Ser Ser His Asn Ser
        275                 280                 285             
Ala Ser Trp Gly Gln Gly Gly Lys Lys Gln Met Lys Cys Ser Leu Lys
    290                 295                 300                 
Gly Gly Asn Asn Asp Ser Trp Met Asn Pro Leu Ala Lys Gln Phe Ser
305                 310                 315                 320 
Asn Met Gly Leu Leu Ser Gln Thr Glu Asp Asn Pro Ser Ser Lys Met
                325                 330                 335     
Asp Leu Ser Val Gly Ser Leu Ser Asp Lys Lys Phe Asp Val Asp Lys
            340                 345                 350         
Arg Ala Met Asn Leu Gly Asp Phe Asn Asp Ile Met Arg Lys Asp Arg
        355                 360                 365             
Ser Gly Phe Arg Pro Pro Asn Ser Lys Asp Met Gly Thr Thr Asp Ser
    370                 375                 380                 
Gly Pro Tyr Phe Glu Lys Gly Gly Ser His Gly Leu Phe Gly Asn Ser
385                 390                 395                 400 
Thr Ala Gln Ser Arg Gly Leu His Thr Pro Val Gln Pro Leu Asn Ser
                405                 410                 415     
Ser Pro Ser Leu Arg Ala Gln Val Pro Pro Gln Phe Ile Ser Pro Gln
            420                 425                 430         
Val Ser Ala Ser Met Leu Lys Gln Phe Pro Asn Ser Gly Leu Ser Pro
        435                 440                 445             
Gly Leu Phe Asn Val Gly Pro Gln Leu Ser Pro Gln Gln Ile Ala Met
    450                 455                 460                 
Leu Ser Gln Leu Pro Gln Ile Pro Gln Phe Gln Leu Ala Cys Gln Leu
465                 470                 475                 480 
Leu Leu Gln Gln Gln Gln Gln Gln Gln Leu Leu Gln Asn Gln Arg Lys
                485                 490                 495     
Ile Ser Gln Ala Val Arg Gln Gln Gln Glu Gln Gln Leu Ala Arg Met
            500                 505                 510         
Val Ser Ala Leu Gln Gln Gln Gln Gln Gln Gln Gln Arg Gln Pro Gly
        515                 520                 525             
Met Lys His Ser Pro Ser His Pro Val Gly Pro Lys Pro His Leu Asp
    530                 535                 540                 
Asn Met Val Pro Asn Ala Leu Asn Val Gly Leu Pro Asp Leu Gln Thr
545                 550                 555                 560 
Lys Gly Pro Ile Pro Gly Tyr Gly Ser Gly Phe Ser Ser Gly Gly Met
                565                 570                 575     
Asp Tyr Gly Met Val Gly Gly Lys Glu Ala Gly Thr Glu Ser Arg Phe
            580                 585                 590         
Lys Gln Trp Thr Ser Met Met Glu Gly Leu Pro Ser Val Ala Thr Gln
        595                 600                 605             
Glu Ala Asn Met His Lys Asn Gly Ala Ile Val Ala Pro Gly Lys Thr
    610                 615                 620                 
Arg Gly Gly Ser Pro Tyr Asn Gln Phe Asp Ile Ile Pro Gly Asp Thr
625                 630                 635                 640 
Leu Gly Gly His Thr Gly Pro Ala Gly Asp Ser Trp Leu Pro Ala Lys
                645                 650                 655     
Ser Pro Pro Thr Asn Lys Ile Gly Ser Lys Ser Ser Asn Ala Ser Trp
            660                 665                 670         
Pro Pro Glu Phe Gln Pro Gly Val Pro Trp Lys Gly Ile Gln Asn Ile
        675                 680                 685             
Asp Pro Glu Ser Asp Pro Tyr Val Thr Pro Gly Ser Val Leu Gly Gly
    690                 695                 700                 
Thr Ala Thr Ser Pro Ile Val Asp Thr Asp His Gln Leu Leu Arg Asp
705                 710                 715                 720 
Asn Thr Thr Gly Ser Asn Ser Ser Leu Asn Thr Ser Leu Pro Ser Pro
                725                 730                 735     
Gly Ala Trp Pro Tyr Ser Ala Ser Asp Asn Ser Phe Thr Asn Val His
            740                 745                 750         
Ser Thr Ser Ala Lys Phe Pro Asp Tyr Lys Ser Thr Trp Ser Pro Asp
        755                 760                 765             
Pro Ile Gly His Asn Pro Thr His Leu Ser Asn Lys Met Trp Lys Asn
    770                 775                 780                 
His Ile Ser Ser Arg Asn Thr Thr Pro Leu Pro Arg Pro Pro Pro Gly
785                 790                 795                 800 
Leu Thr Asn Pro Lys Pro Ser Ser Pro Trp Ser Ser Thr Ala Pro Arg
                805                 810                 815     
Ser Val Arg Gly Trp Gly Thr Gln Asp Ser Arg Leu Ala Ser Ala Ser
            820                 825                 830         
Thr Trp Ser Asp Gly Gly Ser Val Arg Pro Ser Tyr Trp Leu Val Leu
        835                 840                 845             
His Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Ile Cys
    850                 855                 860                 
Met Gln His Gly Pro Leu Leu Thr Phe His Leu Asn Leu Thr Gln Gly
865                 870                 875                 880 
Thr Ala Leu Ile Arg Tyr Ser Thr Lys Gln Glu Ala Ala Lys Ala Gln
                885                 890                 895     
Thr Ala Leu His Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu
            900                 905                 910         
Phe Ala Thr Asp Asp Glu Val Ser Arg Phe Leu Ala Gln Ala Gln Pro
        915                 920                 925             
Pro Thr Pro Ala Ala Thr Pro Ser Ala Pro Ala Ala Gly Trp Gln Ser
    930                 935                 940                 
Leu Glu Thr Gly Gln Asn Gln Ser Asp Pro Val Gly Pro Ala Leu Asn
945                 950                 955                 960 
Leu Phe Gly Gly Ser Thr Gly Leu Gly Gln Trp Ser Ser Ser Ala Gly
                965                 970                 975     
Gly Ser Ser Gly Ala Asp Leu Ala Gly Ala Ser Leu Trp Gly Pro Pro
            980                 985                 990         
Asn Tyr Ser Ser Ser Leu Trp Gly Val Pro Thr Val Glu Asp Pro His
        995                 1000                1005            
Arg Met Gly Ser Pro Ala Pro Leu Leu Pro Gly Asp Leu Leu Gly Gly
    1010                1015                1020                
Gly Ser Asp Ser Ile
1025                


<210> 6650
<211> 713
<212> PRT
<213> Homo sapiens

<400> 6650
Met Ala Lys Pro Ser His Ser Ser Tyr Val Leu Gln Gln Leu Asn Asn
 1               5                  10                  15      
Gln Arg Glu Trp Gly Phe Leu Cys Asp Cys Cys Ile Ala Ile Asp Asp
            20                  25                  30          
Ile Tyr Phe Gln Ala His Lys Ala Val Leu Ala Ala Cys Ser Ser Tyr
        35                  40                  45              
Phe Arg Met Phe Phe Met Asn His Gln His Ser Thr Ala Gln Leu Asn
    50                  55                  60                  
Leu Ser Asn Met Lys Ile Ser Ala Glu Cys Phe Asp Leu Ile Leu Gln
65                  70                  75                  80  
Phe Met Tyr Leu Gly Lys Ile Met Thr Ala Pro Ser Ser Phe Glu Gln
                85                  90                  95      
Phe Lys Val Ala Met Asn Tyr Leu Gln Leu Tyr Asn Val Pro Asp Cys
            100                 105                 110         
Leu Glu Asp Ile Gln Asp Ala Asp Cys Ser Ser Ser Lys Cys Ser Ser
        115                 120                 125             
Ser Ala Ser Ser Lys Gln Asn Ser Lys Met Ile Phe Gly Val Arg Met
    130                 135                 140                 
Tyr Glu Asp Thr Val Ala Arg Asn Gly Asn Glu Ala Asn Arg Trp Cys
145                 150                 155                 160 
Ala Glu Pro Ser Ser Thr Val Asn Thr Pro His Asn Arg Glu Ala Asp
                165                 170                 175     
Glu Glu Ser Leu Gln Leu Gly Asn Phe Pro Glu Pro Leu Phe Asp Val
            180                 185                 190         
Cys Lys Lys Ser Ser Val Ser Lys Leu Ser Thr Pro Lys Glu Arg Val
        195                 200                 205             
Ser Arg Arg Phe Gly Arg Ser Phe Thr Cys Asp Ser Cys Gly Phe Gly
    210                 215                 220                 
Phe Ser Cys Glu Lys Leu Leu Asp Glu His Val Leu Thr Cys Thr Asn
225                 230                 235                 240 
Arg His Leu Tyr Gln Asn Thr Arg Ser Tyr His Arg Ile Val Asp Ile
                245                 250                 255     
Arg Asp Gly Lys Asp Ser Asn Ile Lys Ala Glu Phe Gly Glu Lys Asp
            260                 265                 270         
Ser Ser Lys Thr Phe Ser Ala Gln Thr Asp Lys Tyr Arg Gly Asp Thr
        275                 280                 285             
Ser Gln Ala Ala Asp Asp Ser Ala Ser Thr Thr Gly Ser Arg Lys Ser
    290                 295                 300                 
Ser Thr Val Glu Ser Glu Ile Ala Ser Glu Glu Lys Ser Arg Ala Ala
305                 310                 315                 320 
Glu Arg Lys Arg Ile Ile Ile Lys Met Glu Pro Glu Asp Thr Pro Thr
                325                 330                 335     
Asp Glu Leu Lys Asp Phe Asn Ile Ile Lys Val Thr Asp Lys Asp Cys
            340                 345                 350         
Asn Glu Ser Thr Asp Asn Asp Glu Leu Glu Asp Glu Pro Glu Glu Pro
        355                 360                 365             
Phe Tyr Arg Tyr Tyr Val Glu Glu Asp Val Ser Ile Lys Lys Ser Gly
    370                 375                 380                 
Arg Lys Thr Leu Lys Pro Arg Met Ser Val Ser Ala Asp Glu Arg Gly
385                 390                 395                 400 
Gly Leu Glu Asn Met Arg Pro Pro Asn Asn Ser Ser Pro Val Gln Glu
                405                 410                 415     
Asp Ala Glu Asn Ala Ser Cys Glu Leu Cys Gly Leu Thr Ile Thr Glu
            420                 425                 430         
Glu Asp Leu Ser Ser His Tyr Leu Ala Lys His Ile Glu Asn Ile Cys
        435                 440                 445             
Ala Cys Gly Lys Cys Gly Gln Ile Leu Val Lys Gly Arg Gln Leu Gln
    450                 455                 460                 
Glu His Ala Gln Arg Cys Gly Glu Pro Gln Asp Leu Thr Met Asn Gly
465                 470                 475                 480 
Leu Gly Asn Thr Glu Glu Lys Met Asp Leu Glu Glu Asn Pro Asp Glu
                485                 490                 495     
Gln Ser Glu Ile Arg Asp Met Phe Val Glu Met Leu Asp Asp Phe Arg
            500                 505                 510         
Asp Asn His Tyr Gln Ile Asn Ser Ile Gln Lys Lys Gln Leu Phe Lys
        515                 520                 525             
His Ser Ala Cys Pro Phe Arg Cys Pro Asn Cys Gly Gln Arg Phe Glu
    530                 535                 540                 
Thr Glu Asn Leu Val Val Glu His Met Ser Ser Cys Leu Asp Gln Asp
545                 550                 555                 560 
Met Phe Lys Ser Ala Ile Met Glu Glu Asn Glu Arg Asp His Arg Arg
                565                 570                 575     
Lys His Phe Cys Asn Leu Cys Gly Lys Gly Phe Tyr Gln Arg Cys His
            580                 585                 590         
Leu Arg Glu His Tyr Thr Val His Thr Lys Glu Lys Gln Phe Val Cys
        595                 600                 605             
Gln Thr Cys Gly Lys Gln Phe Leu Arg Glu Arg Gln Leu Arg Leu His
    610                 615                 620                 
Asn Asp Met His Lys Gly Met Ala Arg Tyr Val Cys Ser Ile Cys Asp
625                 630                 635                 640 
Gln Gly Asn Phe Arg Lys His Asp His Val Arg His Met Ile Ser His
                645                 650                 655     
Leu Ser Ala Gly Glu Thr Ile Cys Gln Val Cys Phe Gln Ile Phe Pro
            660                 665                 670         
Asn Asn Glu Gln Leu Glu Gln His Met Asp Val His Leu Tyr Thr Cys
        675                 680                 685             
Gly Ile Cys Gly Ala Lys Phe Asn Leu Arg Lys Asp Met Arg Ser His
    690                 695                 700                 
Tyr Asn Ala Lys His Leu Lys Arg Thr
705                 710             


<210> 6651
<211> 644
<212> PRT
<213> Homo sapiens

<400> 6651
Met Ala Lys Pro Ser His Ser Ser Tyr Val Leu Gln Gln Leu Asn Asn
 1               5                  10                  15      
Gln Arg Glu Trp Gly Phe Leu Cys Asp Cys Cys Ile Ala Ile Asp Asp
            20                  25                  30          
Ile Tyr Phe Gln Ala His Lys Ala Val Leu Ala Ala Cys Ser Ser Tyr
        35                  40                  45              
Phe Arg Met Phe Phe Met Asn His Gln His Ser Thr Ala Gln Leu Asn
    50                  55                  60                  
Leu Ser Asn Met Lys Ile Ser Ala Glu Cys Phe Asp Leu Ile Leu Gln
65                  70                  75                  80  
Phe Met Tyr Leu Gly Lys Ile Met Thr Ala Pro Ser Ser Phe Glu Gln
                85                  90                  95      
Phe Lys Val Ala Met Asn Tyr Leu Gln Leu Tyr Asn Val Pro Asp Cys
            100                 105                 110         
Leu Glu Asp Ile Gln Asp Ala Asp Cys Ser Ser Ser Lys Cys Ser Ser
        115                 120                 125             
Ser Ala Ser Ser Lys Gln Asn Ser Lys Met Ile Phe Gly Val Arg Met
    130                 135                 140                 
Tyr Glu Asp Thr Val Ala Arg Asn Gly Asn Glu Ala Asn Arg Trp Cys
145                 150                 155                 160 
Ala Glu Pro Ser Ser Thr Val Asn Thr Pro His Asn Arg Glu Ala Asp
                165                 170                 175     
Glu Glu Ser Leu Gln Leu Gly Asn Phe Pro Glu Pro Leu Phe Asp Val
            180                 185                 190         
Cys Lys Lys Ser Ser Val Ser Lys Leu Ser Asn Pro Lys Glu Arg Val
        195                 200                 205             
Ser Arg Arg Phe Gly Arg Ser Phe Thr Cys Asp Ser Cys Gly Phe Gly
    210                 215                 220                 
Phe Ser Cys Glu Lys Leu Leu Asp Glu His Val Leu Thr Cys Thr Asn
225                 230                 235                 240 
Arg His Leu Tyr Gln Asn Thr Arg Ser Tyr His Arg Ile Val Asp Ile
                245                 250                 255     
Arg Asp Gly Lys Asp Ser Asn Ile Lys Ala Glu Phe Gly Glu Lys Asp
            260                 265                 270         
Ser Ser Lys Thr Phe Ser Ala Gln Thr Asp Lys Tyr Arg Gly Asp Thr
        275                 280                 285             
Ser Gln Ala Ala Asp Asp Ser Ala Ser Thr Thr Gly Ser Arg Lys Ser
    290                 295                 300                 
Ser Thr Val Glu Ser Glu Ile Ala Ser Glu Glu Lys Ser Arg Ala Ala
305                 310                 315                 320 
Glu Arg Lys Arg Ile Ile Ile Lys Met Glu Pro Glu Asp Ile Pro Thr
                325                 330                 335     
Asp Glu Leu Lys Asp Phe Asn Ile Ile Lys Val Thr Asp Lys Asp Cys
            340                 345                 350         
Asn Glu Ser Thr Asp Asn Asp Glu Leu Glu Asp Glu Pro Glu Glu Pro
        355                 360                 365             
Phe Tyr Arg Tyr Tyr Val Glu Glu Asp Val Ser Ile Lys Lys Ser Gly
    370                 375                 380                 
Arg Lys Thr Leu Lys Pro Arg Met Ser Val Ser Ala Asp Glu Arg Gly
385                 390                 395                 400 
Gly Leu Glu Asn Met Arg Pro Pro Asn Asn Ser Ser Pro Val Gln Glu
                405                 410                 415     
Asp Ala Glu Asn Ala Ser Cys Glu Leu Cys Gly Leu Thr Ile Thr Glu
            420                 425                 430         
Glu Asp Leu Ser Ser His Tyr Leu Ala Lys His Ile Glu Asn Ile Cys
        435                 440                 445             
Ala Cys Gly Lys Cys Gly Gln Ile Leu Val Lys Gly Arg Gln Leu Gln
    450                 455                 460                 
Glu His Ala Gln Arg Cys Gly Glu Pro Gln Asp Leu Thr Met Asn Gly
465                 470                 475                 480 
Leu Gly Asn Thr Glu Glu Lys Met Asp Leu Glu Glu Asn Pro Asp Glu
                485                 490                 495     
Gln Ser Glu Ile Arg Asp Met Phe Val Glu Met Leu Asp Asp Phe Arg
            500                 505                 510         
Asp Asn His Tyr Gln Ile Asn Ser Ile Gln Lys Lys Gln Leu Phe Lys
        515                 520                 525             
His Ser Ala Cys Pro Phe Arg Cys Pro Asn Cys Gly Gln Arg Phe Glu
    530                 535                 540                 
Thr Glu Asn Leu Val Val Glu His Met Ser Ser Cys Leu Asp Gln Asp
545                 550                 555                 560 
Met Phe Lys Ser Ala Ile Met Glu Glu Asn Glu Arg Asp His Arg Arg
                565                 570                 575     
Lys His Phe Cys Asn Leu Cys Gly Lys Gly Phe Tyr Gln Arg Cys His
            580                 585                 590         
Leu Arg Glu His Tyr Thr Val His Thr Lys Glu Lys Gln Phe Val Cys
        595                 600                 605             
Gln Thr Cys Gly Lys Gln Phe Leu Arg Glu Arg Gln Leu Arg Leu His
    610                 615                 620                 
Asn Asp Met His Lys Gly Met Ala Ser Gly Glu Ile Gly Pro Ser Lys
625                 630                 635                 640 
Pro Val Glu Lys
                


<210> 6652
<211> 1739
<212> PRT
<213> Homo sapiens

<400> 6652
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His
 1               5                  10                  15      
Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp
            20                  25                  30          
Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly
        35                  40                  45              
His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser
    50                  55                  60                  
Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro
65                  70                  75                  80  
Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val
                85                  90                  95      
Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser
            100                 105                 110         
Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala
        115                 120                 125             
Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln
    130                 135                 140                 
Leu Lys Lys Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln
145                 150                 155                 160 
Glu Gln Gly Thr Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys
                165                 170                 175     
Ala Arg Arg Pro Val Pro Arg Arg Thr Val Pro Lys Pro Arg Val Lys
            180                 185                 190         
Lys Gln Pro Lys Thr Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser
        195                 200                 205             
Asp Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Thr Arg Arg
    210                 215                 220                 
Arg Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Thr
225                 230                 235                 240 
Asp Ser Asp Asp Leu Ile Glu Met Thr Gly Glu Gly Val Asp Glu Gln
                245                 250                 255     
Gln Asp Asn Ser Glu Thr Ile Glu Lys Val Leu Asp Ser Arg Leu Gly
            260                 265                 270         
Lys Lys Gly Ala Thr Gly Ala Ser Thr Thr Val Tyr Ala Ile Glu Ala
        275                 280                 285             
Asn Gly Asp Pro Ser Gly Asp Phe Asp Thr Glu Lys Asp Glu Gly Glu
    290                 295                 300                 
Ile Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Thr
305                 310                 315                 320 
Trp Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys
                325                 330                 335     
Lys Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu
            340                 345                 350         
Gly Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu
        355                 360                 365             
Leu Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile
    370                 375                 380                 
Ala Val Lys Thr Ser Lys Ser Thr Leu Gly Gln Thr Asp Phe Pro Ala
385                 390                 395                 400 
His Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys
                405                 410                 415     
Trp Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu
            420                 425                 430         
Ile Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn
        435                 440                 445             
Asn Ser Lys Thr Ile Pro Thr Arg Glu Cys Lys Ala Leu Lys Gln Arg
    450                 455                 460                 
Pro Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu
465                 470                 475                 480 
Asn Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala
                485                 490                 495     
His Ser Trp Cys Lys Asn Asn Ser Val Ile Leu Ala Asp Glu Met Gly
            500                 505                 510         
Leu Gly Lys Thr Ile Gln Thr Ile Ser Phe Leu Ser Tyr Leu Phe His
        515                 520                 525             
Gln His Gln Leu Tyr Gly Pro Phe Leu Ile Val Val Pro Leu Ser Thr
    530                 535                 540                 
Leu Thr Ser Trp Gln Arg Glu Phe Glu Ile Trp Ala Pro Glu Ile Asn
545                 550                 555                 560 
Val Val Val Tyr Ile Gly Asp Leu Met Ser Arg Asn Thr Ile Arg Glu
                565                 570                 575     
Tyr Glu Trp Ile His Ser Gln Thr Lys Arg Leu Lys Phe Asn Ala Leu
            580                 585                 590         
Ile Thr Thr Tyr Glu Ile Leu Leu Lys Asp Lys Thr Val Leu Gly Ser
        595                 600                 605             
Ile Asn Trp Ala Phe Leu Gly Val Asp Glu Ala His Arg Leu Lys Asn
    610                 615                 620                 
Asp Asp Ser Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His
625                 630                 635                 640 
Arg Leu Leu Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu
                645                 650                 655     
Trp Ser Leu Leu His Phe Ile Met Pro Glu Lys Phe Glu Phe Trp Glu
            660                 665                 670         
Asp Phe Glu Glu Asp His Gly Lys Gly Arg Glu Asn Gly Tyr Gln Ser
        675                 680                 685             
Leu His Lys Val Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp
    690                 695                 700                 
Val Glu Lys Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Val Glu
705                 710                 715                 720 
Met Ser Ala Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn
                725                 730                 735     
Tyr Lys Ala Leu Ala Lys Gly Thr Arg Gly Ser Thr Ser Gly Phe Leu
            740                 745                 750         
Asn Ile Val Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile
        755                 760                 765             
Lys Pro Pro Glu Glu Asn Glu Arg Glu Asn Gly Gln Glu Ile Leu Leu
    770                 775                 780                 
Ser Leu Ile Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu
785                 790                 795                 800 
Thr Arg Leu Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met
                805                 810                 815     
Val Arg Met Leu Asp Ile Leu Ala Glu Tyr Leu Thr Ile Lys His Tyr
            820                 825                 830         
Pro Phe Gln Arg Leu Asp Gly Ser Ile Lys Gly Glu Ile Arg Lys Gln
        835                 840                 845             
Ala Leu Asp His Phe Asn Ala Asp Gly Ser Glu Asp Phe Cys Phe Leu
    850                 855                 860                 
Leu Ser Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp
865                 870                 875                 880 
Thr Val Val Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln
                885                 890                 895     
Ala Gln Ala Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile
            900                 905                 910         
Tyr Arg Leu Val Thr Lys Gly Thr Val Glu Glu Glu Ile Ile Glu Arg
        915                 920                 925             
Ala Lys Lys Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp
    930                 935                 940                 
Thr Thr Gly Arg Thr Ile Leu Glu Asn Asn Ser Gly Arg Ser Asn Ser
945                 950                 955                 960 
Asn Pro Phe Asn Lys Glu Glu Leu Thr Ala Ile Leu Lys Phe Gly Ala
                965                 970                 975     
Glu Asp Leu Phe Lys Glu Leu Glu Gly Glu Glu Ser Glu Pro Gln Glu
            980                 985                 990         
Met Asp Ile Asp Glu Ile Leu Arg Leu Ala Glu Thr Arg Glu Asn Glu
        995                 1000                1005            
Val Ser Thr Ser Ala Thr Asp Glu Leu Leu Ser Gln Phe Lys Val Ala
    1010                1015                1020                
Asn Phe Ala Thr Met Glu Asp Glu Glu Glu Leu Glu Glu Arg Pro His
1025                1030                1035                1040
Lys Asp Trp Asp Glu Ile Ile Pro Glu Glu Gln Arg Lys Lys Val Glu
                1045                1050                1055    
Glu Glu Glu Arg Gln Lys Glu Leu Glu Glu Ile Tyr Met Leu Pro Arg
            1060                1065                1070        
Ile Arg Ser Ser Thr Lys Lys Ala Gln Thr Asn Asp Ser Asp Ser Asp
        1075                1080                1085            
Thr Glu Ser Lys Arg Gln Ala Gln Arg Ser Ser Ala Ser Glu Ser Glu
    1090                1095                1100                
Thr Glu Asp Ser Asp Asp Asp Lys Lys Pro Lys Arg Arg Gly Arg Pro
1105                1110                1115                1120
Arg Ser Val Arg Lys Asp Leu Val Glu Gly Phe Thr Asp Ala Glu Ile
                1125                1130                1135    
Arg Arg Phe Ile Lys Ala Tyr Lys Lys Phe Gly Leu Pro Leu Glu Arg
            1140                1145                1150        
Leu Glu Cys Leu Ala Arg Asp Ala Glu Leu Val Asp Lys Ser Val Ala
        1155                1160                1165            
Asp Leu Lys Arg Leu Gly Glu Leu Ile His Asn Ser Cys Val Ser Ala
    1170                1175                1180                
Met Gln Glu Tyr Glu Glu Gln Leu Lys Glu Asn Ala Ser Glu Gly Lys
1185                1190                1195                1200
Gly Pro Gly Lys Arg Arg Gly Pro Thr Ile Lys Ile Ser Gly Val Gln
                1205                1210                1215    
Val Asn Val Lys Ser Ile Ile Gln His Glu Glu Glu Phe Glu Met Leu
            1220                1225                1230        
His Lys Ser Ile Pro Val Asp Pro Glu Glu Lys Lys Lys Tyr Cys Leu
        1235                1240                1245            
Thr Cys Arg Val Lys Ala Ala His Phe Asp Val Glu Trp Gly Val Glu
    1250                1255                1260                
Asp Asp Ser Arg Leu Leu Leu Gly Ile Tyr Glu His Gly Tyr Gly Asn
1265                1270                1275                1280
Trp Glu Leu Ile Lys Thr Asp Pro Glu Leu Lys Leu Thr Asp Lys Ile
                1285                1290                1295    
Leu Pro Val Glu Thr Asp Lys Lys Pro Gln Gly Lys Gln Leu Gln Thr
            1300                1305                1310        
Arg Ala Asp Tyr Leu Leu Lys Leu Leu Arg Lys Gly Leu Glu Lys Lys
        1315                1320                1325            
Gly Ala Val Thr Gly Gly Glu Glu Ala Lys Leu Lys Lys Arg Lys Pro
    1330                1335                1340                
Arg Val Lys Lys Glu Asn Lys Val Pro Arg Leu Lys Glu Glu His Gly
1345                1350                1355                1360
Ile Glu Leu Ser Ser Pro Arg His Ser Asp Asn Pro Ser Glu Glu Gly
                1365                1370                1375    
Glu Val Lys Asp Asp Gly Leu Glu Lys Ser Pro Met Lys Lys Lys Gln
            1380                1385                1390        
Lys Lys Lys Glu Asn Lys Glu Asn Lys Glu Lys Gln Met Ser Ser Arg
        1395                1400                1405            
Lys Asp Lys Glu Gly Asp Lys Glu Arg Lys Lys Ser Lys Asp Lys Lys
    1410                1415                1420                
Glu Lys Pro Lys Ser Gly Asp Ala Lys Ser Ser Ser Lys Ser Lys Arg
1425                1430                1435                1440
Ser Gln Gly Pro Val His Ile Thr Ala Gly Ser Glu Pro Val Pro Ile
                1445                1450                1455    
Gly Glu Asp Glu Asp Asp Asp Leu Asp Gln Glu Thr Phe Ser Ile Cys
            1460                1465                1470        
Lys Glu Arg Met Arg Pro Val Lys Lys Ala Leu Lys Gln Leu Asp Lys
        1475                1480                1485            
Pro Asp Lys Gly Leu Asn Val Gln Glu Gln Leu Glu His Thr Arg Asn
    1490                1495                1500                
Cys Leu Leu Lys Ile Gly Asp Arg Ile Ala Glu Cys Leu Lys Ala Tyr
1505                1510                1515                1520
Ser Asp Gln Glu His Ile Lys Leu Trp Arg Arg Asn Leu Trp Ile Phe
                1525                1530                1535    
Val Ser Lys Phe Thr Glu Phe Asp Ala Arg Lys Leu His Lys Leu Tyr
            1540                1545                1550        
Lys Met Ala His Lys Lys Arg Ser Gln Glu Glu Glu Glu Gln Lys Lys
        1555                1560                1565            
Lys Asp Asp Val Thr Gly Gly Lys Lys Pro Phe Arg Pro Glu Ala Ser
    1570                1575                1580                
Gly Ser Ser Arg Asp Ser Leu Ile Ser Gln Ser His Thr Ser His Asn
1585                1590                1595                1600
Leu His Pro Gln Lys Pro His Leu Pro Ala Ser His Gly Pro Gln Met
                1605                1610                1615    
His Gly His Pro Arg Asp Asn Tyr Asn His Pro Asn Lys Arg His Phe
            1620                1625                1630        
Ser Asn Ala Asp Arg Gly Asp Trp Gln Arg Glu Arg Lys Phe Asn Tyr
        1635                1640                1645            
Gly Gly Gly Asn Asn Asn Pro Pro Trp Gly Ser Asp Arg His His Gln
    1650                1655                1660                
Tyr Glu Gln His Trp Tyr Lys Asp His His Tyr Gly Asp Arg Arg His
1665                1670                1675                1680
Met Asp Ala His Arg Ser Gly Ser Tyr Arg Pro Asn Asn Met Ser Arg
                1685                1690                1695    
Lys Arg Pro Tyr Asp Gln Tyr Ser Ser Asp Arg Asp His Arg Gly His
            1700                1705                1710        
Arg Asp Tyr Tyr Asp Arg Tyr Ala Lys Gly Cys Glu Thr Pro Gly Ala
        1715                1720                1725            
Asn Leu Cys Gln Glu Leu Phe Leu Gly Arg Lys
    1730                1735                


<210> 6653
<211> 733
<212> PRT
<213> Homo sapiens

<400> 6653
Met Glu Arg Arg Ser Glu Ser Pro Cys Leu Arg Asp Ser Pro Asp Arg
 1               5                  10                  15      
Arg Ser Gly Ser Pro Asp Val Lys Gly Pro Pro Pro Val Lys Val Ala
            20                  25                  30          
Arg Leu Glu Gln Asn Gly Ser Pro Met Gly Ala Arg Gly Arg Pro Asn
        35                  40                  45              
Gly Ala Val Ala Lys Ala Val Gly Gly Leu Met Ile Pro Val Phe Cys
    50                  55                  60                  
Val Val Glu Gln Leu Asp Gly Ser Leu Glu Tyr Asp Asn Arg Glu Glu
65                  70                  75                  80  
His Ala Glu Phe Val Leu Val Arg Lys Asp Val Leu Phe Ser Gln Leu
                85                  90                  95      
Val Glu Thr Ala Leu Leu Ala Leu Gly Tyr Ser His Ser Ser Ala Ala
            100                 105                 110         
Gln Ala Gln Gly Ile Ile Lys Leu Gly Arg Trp Asn Pro Leu Pro Leu
        115                 120                 125             
Ser Tyr Val Thr Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln
    130                 135                 140                 
Asp Val Tyr His Val Val Thr Leu Lys Ile Gln Leu Gln Ser Cys Ser
145                 150                 155                 160 
Lys Leu Glu Asp Leu Pro Ala Glu Gln Trp Asn His Ala Thr Val Arg
                165                 170                 175     
Asn Ala Leu Lys Glu Leu Leu Lys Glu Met Asn Gln Ser Thr Leu Ala
            180                 185                 190         
Lys Glu Cys Pro Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser
        195                 200                 205             
Thr Tyr Tyr Ala Asn Val Ser Ala Thr Lys Cys Gln Glu Phe Gly Arg
    210                 215                 220                 
Trp Tyr Lys Lys Tyr Lys Lys Ile Lys Val Glu Arg Val Glu Arg Glu
225                 230                 235                 240 
Asn Leu Ser Asp Tyr Cys Val Leu Gly Gln Arg Pro Met His Leu Pro
                245                 250                 255     
Asn Met Asn Gln Leu Ala Ser Leu Gly Lys Thr Asn Glu Gln Ser Pro
            260                 265                 270         
His Ser Gln Ile His His Ser Thr Pro Ile Arg Asn Gln Val Pro Ala
        275                 280                 285             
Leu Gln Pro Ile Met Ser Pro Gly Leu Leu Ser Pro Gln Leu Ser Pro
    290                 295                 300                 
Gln Leu Val Arg Gln Gln Ile Ala Met Ala His Leu Ile Asn Gln Gln
305                 310                 315                 320 
Ile Ala Val Ser Arg Leu Leu Ala His Gln His Pro Gln Ala Ile Asn
                325                 330                 335     
Gln Gln Phe Leu Asn His Pro Pro Ile Pro Arg Ala Val Lys Pro Glu
            340                 345                 350         
Pro Thr Asn Ser Ser Val Glu Val Ser Pro Asp Ile Tyr Gln Gln Val
        355                 360                 365             
Arg Asp Glu Leu Lys Arg Ala Ser Val Ser Gln Ala Val Phe Ala Arg
    370                 375                 380                 
Val Ala Phe Asn Arg Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys
385                 390                 395                 400 
Glu Glu Asp Pro Arg Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg
                405                 410                 415     
Ala Met Gln Asn Phe Leu Asn Leu Pro Glu Val Glu Arg Asp Arg Ile
            420                 425                 430         
Tyr Gln Asp Glu Arg Glu Arg Ser Met Asn Pro Asn Val Ser Met Val
        435                 440                 445             
Ser Ser Ala Ser Ser Ser Pro Ser Ser Ser Arg Thr Pro Gln Ala Lys
    450                 455                 460                 
Thr Ser Thr Pro Thr Thr Asp Leu Pro Ile Lys Val Asp Gly Ala Asn
465                 470                 475                 480 
Ile Asn Ile Thr Ala Ala Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys
                485                 490                 495     
Arg Ala Lys Val Ser Gln Ala Leu Phe Ala Lys Val Ala Ala Asn Lys
            500                 505                 510         
Ser Gln Gly Trp Leu Cys Glu Leu Leu Arg Trp Lys Glu Asn Pro Ser
        515                 520                 525             
Pro Glu Asn Arg Thr Leu Trp Glu Asn Leu Cys Thr Ile Arg Arg Phe
    530                 535                 540                 
Leu Asn Leu Pro Gln His Glu Arg Asp Val Ile Tyr Glu Glu Glu Ser
545                 550                 555                 560 
Arg His His His Ser Glu Arg Met Gln His Val Val Gln Leu Pro Pro
                565                 570                 575     
Glu Pro Val Gln Val Leu His Arg Gln Gln Ser Gln Pro Ala Lys Glu
            580                 585                 590         
Ser Ser Pro Pro Arg Glu Glu Ala Pro Pro Pro Pro Pro Pro Thr Glu
        595                 600                 605             
Asp Ser Cys Ala Lys Lys Pro Arg Ser Arg Thr Lys Ile Ser Leu Glu
    610                 615                 620                 
Ala Leu Gly Ile Leu Gln Ser Phe Ile His Asp Val Gly Leu Tyr Pro
625                 630                 635                 640 
Asp Gln Glu Ala Ile His Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys
                645                 650                 655     
His Thr Ile Ile Lys Phe Phe Gln Asn Gln Arg Tyr His Val Lys His
            660                 665                 670         
His Gly Lys Leu Lys Glu His Leu Gly Ser Ala Val Asp Val Ala Glu
        675                 680                 685             
Tyr Lys Asp Glu Glu Leu Leu Thr Glu Ser Glu Glu Asn Asp Ser Glu
    690                 695                 700                 
Glu Gly Ser Glu Glu Met Tyr Lys Val Glu Ala Glu Glu Glu Asn Ala
705                 710                 715                 720 
Asp Lys Ser Lys Ala Ala Pro Ala Glu Ile Asp Gln Arg
                725                 730             


<210> 6654
<211> 643
<212> PRT
<213> Homo sapiens

<400> 6654
Met Ala Asp Tyr Ser Thr Val Pro Pro Pro Ser Ser Gly Ser Ala Gly
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Asn Asp Ala Phe Lys
            20                  25                  30          
Asp Ala Leu Gln Arg Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp
        35                  40                  45              
Ala Gly Thr Ser Leu Asn Ser Asn Asp Tyr Gly Tyr Gly Gly Gln Lys
    50                  55                  60                  
Arg Pro Leu Glu Asp Gly Asp Gln Pro Asp Ala Lys Lys Val Ala Pro
65                  70                  75                  80  
Gln Asn Asp Ser Phe Gly Thr Gln Leu Pro Pro Met His Gln Gln Gln
                85                  90                  95      
Arg Ser Val Met Thr Glu Glu Tyr Lys Val Pro Asp Gly Met Val Gly
            100                 105                 110         
Phe Ile Ile Gly Arg Gly Gly Glu Gln Ile Ser Arg Ile Gln Gln Glu
        115                 120                 125             
Ser Gly Cys Lys Ile Gln Ile Ala Pro Asp Ser Gly Gly Leu Pro Glu
    130                 135                 140                 
Arg Ser Cys Met Leu Thr Gly Thr Pro Glu Ser Val Gln Ser Ala Lys
145                 150                 155                 160 
Arg Leu Leu Asp Gln Ile Val Glu Lys Gly Arg Pro Ala Pro Gly Phe
                165                 170                 175     
His His Gly Asp Gly Pro Gly Asn Ala Val Gln Glu Ile Met Ile Pro
            180                 185                 190         
Ala Ser Lys Ala Gly Leu Val Ile Gly Lys Gly Gly Glu Thr Ile Lys
        195                 200                 205             
Gln Leu Gln Glu Arg Ala Gly Val Lys Met Val Met Ile Gln Asp Gly
    210                 215                 220                 
Pro Gln Asn Thr Gly Ala Asp Lys Pro Leu Arg Ile Thr Gly Asp Pro
225                 230                 235                 240 
Tyr Lys Val Gln Gln Ala Lys Glu Met Val Leu Glu Leu Ile Arg Asp
                245                 250                 255     
Gln Gly Gly Phe Arg Glu Val Arg Asn Glu Tyr Gly Ser Arg Ile Gly
            260                 265                 270         
Gly Asn Glu Gly Ile Asp Val Pro Ile Pro Arg Phe Ala Val Gly Ile
        275                 280                 285             
Val Ile Gly Arg Asn Gly Glu Met Ile Lys Lys Ile Gln Asn Asp Ala
    290                 295                 300                 
Gly Val Arg Ile Gln Phe Lys Pro Asp Asp Gly Thr Thr Pro Glu Arg
305                 310                 315                 320 
Ile Ala Gln Ile Thr Gly Pro Pro Asp Arg Cys Gln His Ala Ala Glu
                325                 330                 335     
Ile Ile Thr Asp Leu Leu Arg Ser Val Gln Ala Gly Asn Pro Gly Gly
            340                 345                 350         
Pro Gly Pro Gly Gly Arg Gly Arg Gly Arg Gly Gln Gly Asn Trp Asn
        355                 360                 365             
Met Gly Pro Pro Gly Gly Leu Gln Glu Phe Asn Phe Ile Val Pro Thr
    370                 375                 380                 
Gly Lys Thr Gly Leu Ile Ile Gly Lys Gly Gly Glu Thr Ile Lys Ser
385                 390                 395                 400 
Ile Ser Gln Gln Ser Gly Ala Arg Ile Glu Leu Gln Arg Asn Pro Pro
                405                 410                 415     
Pro Asn Ala Asp Pro Asn Met Lys Leu Phe Thr Ile Arg Gly Thr Pro
            420                 425                 430         
Gln Gln Ile Asp Tyr Ala Arg Gln Leu Ile Glu Glu Lys Ile Gly Gly
        435                 440                 445             
Pro Val Asn Pro Leu Gly Pro Pro Val Pro His Gly Pro His Gly Val
    450                 455                 460                 
Pro Gly Pro His Gly Pro Pro Gly Pro Pro Gly Pro Gly Thr Pro Met
465                 470                 475                 480 
Gly Pro Tyr Asn Pro Ala Pro Tyr Asn Pro Gly Pro Pro Gly Pro Ala
                485                 490                 495     
Pro His Gly Pro Pro Ala Pro Tyr Ala Pro Gln Gly Trp Gly Asn Ala
            500                 505                 510         
Tyr Pro His Trp Gln Gln Gln Ala Pro Pro Asp Pro Ala Lys Ala Gly
        515                 520                 525             
Thr Asp Pro Asn Ser Ala Ala Trp Ala Ala Tyr Tyr Ala His Tyr Tyr
    530                 535                 540                 
Gln Gln Gln Ala Gln Pro Pro Pro Ala Ala Pro Ala Gly Ala Pro Thr
545                 550                 555                 560 
Thr Thr Gln Thr Asn Gly Gln Gly Asp Gln Gln Asn Pro Ala Pro Ala
                565                 570                 575     
Gly Gln Val Asp Tyr Thr Lys Ala Trp Glu Glu Tyr Tyr Lys Lys Met
            580                 585                 590         
Gly Gln Ala Val Pro Ala Pro Thr Gly Ala Pro Pro Gly Gly Gln Pro
        595                 600                 605             
Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Ala Ala Tyr
    610                 615                 620                 
Tyr Ala Gln Thr Ser Pro Gln Gly Met Pro Gln His Pro Pro Ala Pro
625                 630                 635                 640 
Gln Gly Gln
            


<210> 6655
<211> 654
<212> PRT
<213> Homo sapiens

<400> 6655
Met Ala Asp Tyr Ser Thr Val Pro Pro Pro Ser Ser Gly Ser Ala Gly
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Asn Asp Ala Phe Lys
            20                  25                  30          
Asp Ala Leu Gln Arg Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp
        35                  40                  45              
Ala Gly Thr Ser Leu Asn Ser Asn Asp Tyr Gly Tyr Gly Gly Gln Lys
    50                  55                  60                  
Arg Pro Leu Glu Asp Gly Asp Gln Pro Asp Ala Lys Lys Val Ala Pro
65                  70                  75                  80  
Gln Asn Asp Ser Phe Gly Thr Gln Leu Pro Pro Met His Gln Gln Gln
                85                  90                  95      
Arg Ser Val Met Thr Glu Glu Tyr Lys Val Pro Asp Gly Met Val Gly
            100                 105                 110         
Phe Ile Ile Gly Arg Gly Gly Glu Gln Ile Ser Arg Ile Gln Gln Glu
        115                 120                 125             
Ser Gly Cys Lys Ile Gln Ile Ala Pro Asp Ser Gly Gly Leu Pro Glu
    130                 135                 140                 
Arg Ser Cys Met Leu Thr Gly Thr Pro Glu Ser Val Gln Ser Ala Lys
145                 150                 155                 160 
Arg Leu Leu Asp Gln Ile Val Glu Lys Gly Arg Pro Ala Pro Gly Phe
                165                 170                 175     
His His Gly Asp Gly Pro Gly Asn Ala Val Gln Glu Ile Met Ile Pro
            180                 185                 190         
Ala Ser Lys Ala Gly Leu Val Ile Gly Lys Gly Gly Glu Thr Ile Lys
        195                 200                 205             
Gln Leu Gln Glu Arg Ala Gly Val Lys Met Val Met Ile Gln Asp Gly
    210                 215                 220                 
Pro Gln Asn Thr Gly Ala Asp Lys Pro Leu Arg Ile Thr Gly Asp Pro
225                 230                 235                 240 
Tyr Lys Val Gln Gln Ala Lys Glu Met Val Leu Glu Leu Ile Arg Asp
                245                 250                 255     
Gln Gly Gly Phe Arg Glu Val Arg Asn Glu Tyr Gly Ser Arg Ile Gly
            260                 265                 270         
Gly Asn Glu Gly Ile Asp Val Pro Ile Pro Arg Phe Ala Val Gly Ile
        275                 280                 285             
Val Ile Gly Arg Asn Gly Glu Met Ile Lys Lys Ile Gln Asn Asp Ala
    290                 295                 300                 
Gly Val Arg Ile Gln Phe Lys Pro Asp Asp Gly Thr Thr Pro Glu Arg
305                 310                 315                 320 
Ile Ala Gln Ile Thr Gly Pro Pro Asp Arg Cys Gln His Ala Ala Glu
                325                 330                 335     
Ile Ile Thr Asp Leu Leu Arg Ser Val Gln Ala Gly Asn Pro Gly Gly
            340                 345                 350         
Pro Gly Pro Gly Gly Arg Gly Arg Gly Arg Gly Gln Gly Asn Trp Asn
        355                 360                 365             
Met Gly Pro Pro Gly Gly Leu Gln Glu Phe Asn Phe Ile Val Pro Thr
    370                 375                 380                 
Gly Lys Thr Gly Leu Ile Ile Gly Lys Gly Arg Gly Glu Thr Ile Lys
385                 390                 395                 400 
Ser Ile Ser Gln Gln Ser Gly Ala Arg Ile Glu Leu Gln Arg Asn Pro
                405                 410                 415     
Pro Pro Asn Ala Asp Pro Asn Met Lys Leu Phe Thr Ile Arg Gly Thr
            420                 425                 430         
Pro Gln Gln Ile Asp Tyr Ala Arg Gln Leu Ile Glu Glu Lys Ile Gly
        435                 440                 445             
Gly Pro Val Asn Pro Leu Gly Pro Pro Val Pro His Gly Pro His Gly
    450                 455                 460                 
Val Pro Gly Pro His Gly Pro Pro Gly Pro Pro Gly Pro Gly Thr Pro
465                 470                 475                 480 
Met Gly Pro Tyr Asn Pro Ala Pro Tyr Asn Pro Gly Pro Pro Gly Pro
                485                 490                 495     
Ala Pro His Gly Pro Pro Ala Pro Tyr Ala Pro Gln Gly Trp Gly Asn
            500                 505                 510         
Ala Tyr Pro His Trp Gln Gln Gln Ala Pro Pro Asp Pro Ala Lys Ala
        515                 520                 525             
Gly Thr Asp Pro Asn Ser Ala Ala Trp Ala Ala Tyr Tyr Ala His Tyr
    530                 535                 540                 
Tyr Gln Gln Gln Ala Gln Pro Pro Pro Ala Ala Pro Ala Gly Ala Pro
545                 550                 555                 560 
Thr Thr Thr Gln Thr Asn Gly Gln Gly Asp Gln Gln Asn Pro Ala Pro
                565                 570                 575     
Ala Gly Gln Val Asp Tyr Thr Lys Ala Trp Glu Glu Tyr Tyr Lys Lys
            580                 585                 590         
Met Gly Gln Ala Val Pro Ala Pro Thr Gly Ala Pro Pro Gly Gly Gln
        595                 600                 605             
Pro Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Ala Ala
    610                 615                 620                 
Tyr Tyr Ala Gln Thr Ser Pro Gln Gly Met Pro Gln His Pro Pro Ala
625                 630                 635                 640 
Pro Gln Cys Arg Phe Asp Pro Ala Ser Ile Glu Leu Ala Leu
                645                 650                 


<210> 6656
<211> 707
<212> PRT
<213> Homo sapiens

<400> 6656
Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys
 1               5                  10                  15      
Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu
            20                  25                  30          
Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile
        35                  40                  45              
Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val
    50                  55                  60                  
Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys
65                  70                  75                  80  
Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys
                85                  90                  95      
Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala
            100                 105                 110         
Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala
        115                 120                 125             
Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp
    130                 135                 140                 
Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp
145                 150                 155                 160 
Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys
                165                 170                 175     
Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp
            180                 185                 190         
Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu
        195                 200                 205             
Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val
    210                 215                 220                 
Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu
225                 230                 235                 240 
Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp
                245                 250                 255     
Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro
            260                 265                 270         
Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys
        275                 280                 285             
Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr
    290                 295                 300                 
Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala
305                 310                 315                 320 
Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu
                325                 330                 335     
Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val
            340                 345                 350         
Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly
        355                 360                 365             
Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys
    370                 375                 380                 
Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu
385                 390                 395                 400 
Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala
                405                 410                 415     
Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala
            420                 425                 430         
Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu
        435                 440                 445             
Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr
    450                 455                 460                 
Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr
465                 470                 475                 480 
Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser
                485                 490                 495     
Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile
            500                 505                 510         
Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile
        515                 520                 525             
Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn
    530                 535                 540                 
Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro
545                 550                 555                 560 
Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val
                565                 570                 575     
Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe
            580                 585                 590         
Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser
        595                 600                 605             
Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys
    610                 615                 620                 
Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val Thr Leu Asp
625                 630                 635                 640 
Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg Gly Gly Gly
                645                 650                 655     
Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly
            660                 665                 670         
Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Phe Arg
        675                 680                 685             
Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly Lys Lys Thr
    690                 695                 700                 
Lys Phe Glu
705         


<210> 6657
<211> 484
<212> PRT
<213> Homo sapiens

<400> 6657
Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys Met Ala Pro Pro Pro Lys
 1               5                  10                  15      
Glu Val Glu Glu Asp Ser Glu Asp Glu Glu Met Ser Glu Asp Glu Glu
            20                  25                  30          
Asp Asp Ser Ser Gly Glu Glu Val Val Ile Pro Gln Lys Lys Gly Lys
        35                  40                  45              
Lys Ala Ala Ala Thr Ser Ala Lys Lys Val Val Val Ser Pro Thr Lys
    50                  55                  60                  
Lys Val Ala Val Ala Thr Pro Ala Lys Lys Ala Ala Val Thr Pro Gly
65                  70                  75                  80  
Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys Thr Val Thr Pro Ala Lys
                85                  90                  95      
Ala Val Thr Thr Pro Gly Lys Lys Gly Ala Thr Pro Gly Lys Ala Leu
            100                 105                 110         
Val Ala Thr Pro Gly Lys Lys Gly Ala Ala Ile Pro Ala Lys Gly Ala
        115                 120                 125             
Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp Ser Asp Glu Glu Glu Asp
    130                 135                 140                 
Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp Glu Asp Glu Asp Glu Asp
145                 150                 155                 160 
Glu Asp Glu Ile Glu Pro Ala Ala Met Lys Ala Ala Ala Ala Ala Pro
                165                 170                 175     
Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp
            180                 185                 190         
Asp Asp Asp Glu Glu Asp Gly Lys Glu Leu Ser Trp Ile Ala Tyr Ile
        195                 200                 205             
Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu Lys Gln
    210                 215                 220                 
Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr Gly Glu
225                 230                 235                 240 
Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr Trp Ser
                245                 250                 255     
Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser Ala Thr
            260                 265                 270         
Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile Lys Val
        275                 280                 285             
Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile Glu Phe
    290                 295                 300                 
Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn Lys Arg
305                 310                 315                 320 
Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro Arg Gly
                325                 330                 335     
Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val Lys Gly
            340                 345                 350         
Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe Asp Gly
        355                 360                 365             
Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser Ser Lys
    370                 375                 380                 
Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys Ala Ala
385                 390                 395                 400 
Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val Thr Leu
                405                 410                 415     
Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg Gly Gly
            420                 425                 430         
Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly
        435                 440                 445             
Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Phe
    450                 455                 460                 
Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly Lys Lys
465                 470                 475                 480 
Thr Lys Phe Glu
                


<210> 6658
<211> 687
<212> PRT
<213> Homo sapiens

<400> 6658
Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys
 1               5                  10                  15      
Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu
            20                  25                  30          
Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile
        35                  40                  45              
Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val
    50                  55                  60                  
Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Ala
65                  70                  75                  80  
Val Thr Thr Pro Gly Lys Lys Gly Ala Thr Pro Gly Lys Ala Leu Val
                85                  90                  95      
Ala Thr Pro Gly Lys Lys Gly Ala Ala Ile Pro Ala Lys Gly Ala Lys
            100                 105                 110         
Asn Gly Lys Asn Ala Lys Lys Glu Asp Ser Asp Glu Glu Glu Asp Asp
        115                 120                 125             
Asp Ser Glu Glu Asp Glu Glu Asp Asp Glu Asp Glu Asp Glu Asp Glu
    130                 135                 140                 
Asp Glu Ile Glu Pro Ala Ala Met Lys Ala Ala Ala Ala Ala Pro Ala
145                 150                 155                 160 
Ser Glu Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Asp
                165                 170                 175     
Asp Asp Glu Glu Asp Asp Ser Glu Glu Glu Ala Met Glu Thr Thr Pro
            180                 185                 190         
Ala Lys Gly Lys Lys Ala Ala Lys Val Val Pro Val Lys Ala Lys Asn
        195                 200                 205             
Val Ala Glu Asp Glu Asp Glu Glu Glu Asp Asp Glu Asp Glu Asp Asp
    210                 215                 220                 
Asp Asp Asp Glu Asp Asp Glu Asp Asp Asp Asp Glu Asp Asp Glu Glu
225                 230                 235                 240 
Glu Glu Glu Glu Glu Glu Glu Glu Pro Val Lys Glu Ala Pro Gly Lys
                245                 250                 255     
Arg Lys Lys Glu Met Ala Lys Gln Lys Ala Ala Pro Glu Ala Lys Lys
            260                 265                 270         
Gln Lys Val Glu Gly Thr Glu Pro Thr Thr Ala Phe Asn Leu Phe Val
        275                 280                 285             
Gly Asn Leu Asn Phe Asn Lys Ser Ala Pro Glu Leu Lys Thr Gly Ile
    290                 295                 300                 
Ser Asp Val Phe Ala Lys Asn Asp Leu Ala Val Val Asp Val Arg Ile
305                 310                 315                 320 
Gly Met Thr Arg Lys Phe Gly Tyr Val Asp Phe Glu Ser Ala Glu Asp
                325                 330                 335     
Leu Glu Lys Ala Leu Glu Leu Thr Gly Leu Lys Val Phe Gly Asn Glu
            340                 345                 350         
Ile Lys Leu Glu Lys Pro Lys Gly Lys Asp Ser Lys Lys Glu Arg Asp
        355                 360                 365             
Ala Arg Thr Leu Leu Ala Lys Asn Leu Pro Tyr Lys Val Thr Gln Asp
    370                 375                 380                 
Glu Leu Lys Glu Val Phe Glu Asp Ala Ala Glu Ile Arg Leu Val Ser
385                 390                 395                 400 
Lys Asp Gly Lys Ser Lys Gly Ile Ala Tyr Ile Glu Phe Lys Thr Glu
                405                 410                 415     
Ala Asp Ala Glu Lys Thr Phe Glu Glu Lys Gln Gly Thr Glu Ile Asp
            420                 425                 430         
Gly Arg Ser Ile Ser Leu Tyr Tyr Thr Gly Glu Lys Gly Gln Asn Gln
        435                 440                 445             
Asp Tyr Arg Gly Gly Lys Asn Ser Thr Trp Ser Gly Glu Ser Lys Thr
    450                 455                 460                 
Leu Val Leu Ser Asn Leu Ser Tyr Ser Ala Thr Glu Glu Thr Leu Gln
465                 470                 475                 480 
Glu Val Phe Glu Lys Ala Thr Phe Ile Lys Val Pro Gln Asn Gln Asn
                485                 490                 495     
Gly Lys Ser Lys Gly Tyr Ala Phe Ile Glu Phe Ala Ser Phe Glu Asp
            500                 505                 510         
Ala Lys Glu Ala Leu Asn Ser Cys Asn Lys Arg Glu Ile Gly Gly Arg
        515                 520                 525             
Ala Ile Arg Leu Glu Leu Gln Gly Pro Arg Gly Ser Pro Asn Ala Arg
    530                 535                 540                 
Ser Gln Pro Ser Lys Thr Leu Phe Val Lys Gly Leu Ser Glu Asp Thr
545                 550                 555                 560 
Thr Glu Glu Thr Leu Lys Glu Ser Phe Asp Gly Ser Val Arg Ala Arg
                565                 570                 575     
Ile Val Thr Asp Arg Glu Thr Gly Ser Ser Lys Gly Phe Gly Phe Val
            580                 585                 590         
Asp Phe Asn Ser Glu Glu Asp Ala Lys Ala Ala Lys Glu Ala Met Glu
        595                 600                 605             
Asp Gly Glu Ile Asp Gly Asn Lys Val Thr Leu Asp Trp Ala Lys Pro
    610                 615                 620                 
Lys Gly Glu Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly Phe
625                 630                 635                 640 
Gly Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Phe Gly Gly Arg
                645                 650                 655     
Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Phe Arg Gly Gly Arg Gly
            660                 665                 670         
Gly Gly Gly Asp His Lys Pro Gln Gly Lys Lys Thr Lys Phe Glu
        675                 680                 685         


<210> 6659
<211> 280
<212> PRT
<213> Homo sapiens

<400> 6659
Met Lys Phe Arg Ala Lys Ile Val Asp Gly Ala Cys Leu Asn His Phe
 1               5                  10                  15      
Thr Arg Ile Ser Asn Met Ile Ala Lys Leu Ala Lys Thr Cys Thr Leu
            20                  25                  30          
Arg Ile Ser Pro Asp Lys Leu Asn Phe Ile Leu Cys Asp Lys Leu Ala
        35                  40                  45              
Asn Gly Gly Val Ser Met Trp Cys Glu Leu Glu Gln Glu Asn Phe Phe
    50                  55                  60                  
Asn Glu Phe Gln Met Glu Gly Val Ser Ala Glu Asn Asn Glu Ile Tyr
65                  70                  75                  80  
Leu Glu Leu Thr Ser Glu Asn Leu Ser Arg Ala Leu Lys Thr Ala Gln
                85                  90                  95      
Asn Ala Arg Ala Leu Lys Ile Lys Leu Thr Asn Lys His Phe Pro Cys
            100                 105                 110         
Leu Thr Val Ser Val Glu Leu Leu Ser Met Ser Ser Ser Ser Arg Ile
        115                 120                 125             
Val Thr His Asp Ile Pro Ile Lys Val Ile Pro Arg Lys Leu Trp Lys
    130                 135                 140                 
Asp Leu Gln Glu Pro Val Val Pro Asp Pro Asp Val Ser Ile Tyr Leu
145                 150                 155                 160 
Pro Val Leu Lys Thr Met Lys Ser Val Val Glu Lys Met Lys Asn Ile
                165                 170                 175     
Ser Asn His Leu Val Ile Glu Ala Asn Leu Asp Gly Glu Leu Asn Leu
            180                 185                 190         
Lys Ile Glu Thr Glu Leu Val Cys Val Thr Thr His Phe Lys Asp Leu
        195                 200                 205             
Gly Asn Pro Pro Leu Ala Ser Glu Ser Thr His Glu Asp Arg Asn Val
    210                 215                 220                 
Glu His Met Ala Glu Val His Ile Asp Ile Arg Lys Leu Leu Gln Phe
225                 230                 235                 240 
Leu Ala Gly Gln Gln Val Asn Pro Thr Lys Ala Leu Cys Asn Ile Val
                245                 250                 255     
Asn Asn Lys Met Val His Phe Asp Leu Leu His Glu Asp Val Ser Leu
            260                 265                 270         
Gln Tyr Phe Ile Pro Ala Leu Ser
        275                 280 


<210> 6660
<211> 652
<212> PRT
<213> Homo sapiens

<400> 6660
Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser
 1               5                  10                  15      
Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His
            20                  25                  30          
Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys
        35                  40                  45              
Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe
    50                  55                  60                  
Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile
65                  70                  75                  80  
Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95      
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110         
Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125             
Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp
    130                 135                 140                 
Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn
145                 150                 155                 160 
Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp
                165                 170                 175     
Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val
            180                 185                 190         
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe
        195                 200                 205             
Ala Ala Tyr His Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp
    210                 215                 220                 
Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe
225                 230                 235                 240 
Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255     
Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser
            260                 265                 270         
Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys
        275                 280                 285             
Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn
    290                 295                 300                 
Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp
305                 310                 315                 320 
Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys
                325                 330                 335     
Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr
            340                 345                 350         
Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile
        355                 360                 365             
Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn
    370                 375                 380                 
Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr
385                 390                 395                 400 
Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser
                405                 410                 415     
Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala
            420                 425                 430         
Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His
        435                 440                 445             
Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr
    450                 455                 460                 
His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His
465                 470                 475                 480 
Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys
                485                 490                 495     
Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly
            500                 505                 510         
Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala
        515                 520                 525             
Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu
    530                 535                 540                 
Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn
545                 550                 555                 560 
Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser
                565                 570                 575     
Asn Cys Glu Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr
            580                 585                 590         
Met Ala Pro Pro Val Met Ala Tyr Pro Ala Thr Thr Pro Thr Gly Met
        595                 600                 605             
Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly Ser Val Pro Val Met Thr
    610                 615                 620                 
Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro
625                 630                 635                 640 
Phe Gly Pro Val Ser Gly Ala Gln Ile Gln Phe Met
                645                 650         


<210> 6661
<211> 634
<212> PRT
<213> Homo sapiens

<400> 6661
Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser
 1               5                  10                  15      
Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His
            20                  25                  30          
Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys
        35                  40                  45              
Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe
    50                  55                  60                  
Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile
65                  70                  75                  80  
Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95      
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110         
Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125             
Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp
    130                 135                 140                 
Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn
145                 150                 155                 160 
Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp
                165                 170                 175     
Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val
            180                 185                 190         
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe
        195                 200                 205             
Ala Ala Tyr His Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp
    210                 215                 220                 
Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe
225                 230                 235                 240 
Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255     
Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser
            260                 265                 270         
Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys
        275                 280                 285             
Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn
    290                 295                 300                 
Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp
305                 310                 315                 320 
Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys
                325                 330                 335     
Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr
            340                 345                 350         
Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile
        355                 360                 365             
Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn
    370                 375                 380                 
Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr
385                 390                 395                 400 
Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser
                405                 410                 415     
Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala
            420                 425                 430         
Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His
        435                 440                 445             
Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr
    450                 455                 460                 
His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His
465                 470                 475                 480 
Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys
                485                 490                 495     
Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly
            500                 505                 510         
Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala
        515                 520                 525             
Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu
    530                 535                 540                 
Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn
545                 550                 555                 560 
Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser
                565                 570                 575     
Asn Cys Glu Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr
            580                 585                 590         
Met Pro Pro Pro Pro Gln Met Gly Ser Val Pro Val Met Thr Gln Pro
        595                 600                 605             
Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro Phe Gly
    610                 615                 620                 
Pro Val Ser Gly Ala Gln Ile Gln Phe Met
625                 630                 


<210> 6662
<211> 348
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 154
<223> Xaa = Any Amino Acid

<400> 6662
Met Leu Ser Leu Glu Lys Ser Arg Leu Lys Thr Thr His Trp Gly Gly
 1               5                  10                  15      
Gly Gly Ser Glu Asp Ser Gly Arg Gln Gly Ala Phe Val Ala Phe Pro
            20                  25                  30          
Glu Arg Ser Gly Val Cys Glu Val Val Ser Ile Met Phe Ser Phe Asn
        35                  40                  45              
Met Phe Asn His Leu Ile Pro Arg Val Phe Gln Asn Arg Phe Ser Thr
    50                  55                  60                  
His Tyr Arg Cys Phe Ser Val Ser Thr Leu Ala Gly Pro Asn Asp Lys
65                  70                  75                  80  
Ser Asp Val Glu Lys Gly Gly Lys Ile Ile Met Leu Pro Ser Ala Leu
                85                  90                  95      
Asp Gln Leu Ser Gln Leu Asn Ile Thr Tyr Pro Met Leu Phe Lys Leu
            100                 105                 110         
Thr Ser Lys Asn Leu Asp Arg Met Thr His Cys Gly Val Leu Glu Phe
        115                 120                 125             
Val Ala Asp Glu Gly Ile Cys Tyr Leu Pro His Trp Met Met Gln Asn
    130                 135                 140                 
Leu Leu Leu Glu Glu Gly Ser Leu Val Xaa Val Glu Ser Val Asn Leu
145                 150                 155                 160 
Gln Val Ala Thr Tyr Ser Lys Phe Gln Pro Gln Ser Pro Asp Ile Leu
                165                 170                 175     
Asp Ile Thr Asn Pro Lys Ala Val Leu Asp Asn Ala Leu Arg Asn Phe
            180                 185                 190         
Ala Cys Leu Thr Thr Gly Asn Val Thr Ala Ile Asn Cys Asn Glu Lys
        195                 200                 205             
Ile Tyr Glu Leu Glu Leu Arg Val Met Glu Thr Lys Pro Asn Lys Ala
    210                 215                 220                 
Val Ser Ile Thr Glu Cys Asp Thr Asn Val Asp Ser Asp Ala Pro Leu
225                 230                 235                 240 
Gly Tyr Lys Glu Pro Glu Arg Gln Val Gln His Glu Glu Leu Thr Glu
                245                 250                 255     
Gly Glu Ala Asp His Ser Gly Tyr Ala Gly Glu Leu Gly Phe Arg Ala
            260                 265                 270         
Phe Ser Gly Ser Gly Asn Arg Leu Asp Gly Lys Lys Glu Ser Pro Ser
        275                 280                 285             
Pro Ile Lys Pro Gly Asp Ile Lys Arg Gly Ile Pro Asn His Glu Phe
    290                 295                 300                 
Lys Leu Gly Lys Thr Pro Phe Ile Arg Asn Ala Cys Pro Leu Val Lys
305                 310                 315                 320 
Lys Phe Glu Glu Asp Glu Ala Gly Gly Arg Phe Val Ala Phe Ser Gly
                325                 330                 335     
Glu Gly Gln Ser Leu Ser Lys Lys Gly Arg Lys Pro
            340                 345             


<210> 6663
<211> 987
<212> PRT
<213> Homo sapiens

<400> 6663
Met Thr Pro Ala Leu Arg Glu Ala Thr Ala Lys Gly Ile Ser Phe Ser
 1               5                  10                  15      
Ser Leu Pro Ser Thr Met Glu Ser Asp Lys Met Leu Tyr Met Glu Ser
            20                  25                  30          
Pro Arg Thr Val Asp Glu Lys Leu Lys Gly Asp Thr Phe Ser Gln Met
        35                  40                  45              
Leu Gly Phe Pro Thr Pro Glu Pro Thr Leu Asn Thr Asn Phe Val Asn
    50                  55                  60                  
Leu Lys His Phe Gly Ser Pro Gln Ser Ser Lys His Tyr Gln Thr Val
65                  70                  75                  80  
Phe Leu Met Arg Ser Asn Ser Thr Leu Asn Lys His Asn Glu Asn Tyr
                85                  90                  95      
Lys Gln Lys Lys Leu Gly Glu Pro Ser Cys Asn Lys Leu Lys Asn Ile
            100                 105                 110         
Leu Tyr Asn Gly Ser Asn Ile Gln Leu Ser Lys Ile Cys Leu Ser His
        115                 120                 125             
Ser Glu Glu Phe Ile Lys Lys Glu Pro Leu Ser Asp Thr Thr Ser Gln
    130                 135                 140                 
Cys Met Lys Asp Val Gln Ile Ile Leu Asp Ser Asn Ile Thr Lys Asp
145                 150                 155                 160 
Thr Asn Val Asp Lys Val Gln Leu Gln Asn Cys Lys Trp Tyr Gln Glu
                165                 170                 175     
Asn Ala Leu Leu Asp Lys Val Thr Asp Ala Glu Ile Lys Lys Gly Leu
            180                 185                 190         
Leu His Cys Thr Gln Lys Lys Ile Val Pro Gly His Ser Asn Val Pro
        195                 200                 205             
Val Ser Ser Ser Ala Ala Glu Lys Glu Glu Glu Val His Ala Arg Leu
    210                 215                 220                 
Leu His Cys Val Ser Lys Gln Lys Ile Leu Leu Ser Gln Ala Arg Arg
225                 230                 235                 240 
Thr Gln Lys His Leu Gln Met Leu Leu Ala Lys His Val Val Lys His
                245                 250                 255     
Tyr Gly Gln Gln Met Lys Leu Ser Met Lys His Gln Leu Pro Lys Met
            260                 265                 270         
Lys Thr Phe His Glu Pro Thr Thr Ile Leu Gly Asn Ser Leu Pro Lys
        275                 280                 285             
Cys Thr Glu Ile Lys Pro Glu Val Asn Thr Leu Thr Ala Glu Asn Lys
    290                 295                 300                 
Leu Trp Asp Asp Ala Lys Asn Gly Phe Ala Arg Cys Thr Ala Ala Glu
305                 310                 315                 320 
Ile Gln Arg Phe Ala Phe Ser Ala Thr Gly Leu Leu Ser His Val Glu
                325                 330                 335     
Glu Gly Leu Asp Ser Asp Ala Thr Asp Ser Ser Ser Asp Asp Asp Leu
            340                 345                 350         
Asp Glu Tyr Thr Leu Arg Lys Asn Val Ala Val Asn Cys Ser Thr Glu
        355                 360                 365             
Trp Lys Trp Leu Val Asp Arg Ala Arg Val Gly Ser Arg Trp Thr Trp
    370                 375                 380                 
Leu Gln Ala Gln Ile Ser Asp Leu Glu Cys Lys Ile Gln Gln Leu Thr
385                 390                 395                 400 
Asp Ile His Arg Gln Ile Arg Ala Ser Lys Gly Ile Val Val Leu Glu
                405                 410                 415     
Glu Cys Gln Leu Pro Lys Asp Ile Leu Lys Lys Gln Met Gln Phe Ala
            420                 425                 430         
Asp Gln Ala Ala Ser Leu Asn Ile Leu Gly Asn Pro Gln Val Pro Gln
        435                 440                 445             
Glu Cys Gln Asp Pro Val Pro Glu Gln Asp Phe Glu Met Ser Pro Ser
    450                 455                 460                 
Ser Pro Thr Leu Leu Leu Arg Asn Ile Glu Lys Gln Ser Ala Gln Leu
465                 470                 475                 480 
Thr Glu Ile Ile Asn Ser Leu Ile Ala Pro Leu Asn Leu Ser Pro Thr
                485                 490                 495     
Ser Ser Pro Leu Ser Ser Lys Ser Cys Ser His Lys Cys Leu Ala Asn
            500                 505                 510         
Gly Ile Tyr Arg Ser Ala Ser Glu Asn Leu Asp Glu Leu Ser Ser Ser
        515                 520                 525             
Ser Ser Trp Leu Leu Asn Gln Lys His Ser Lys Lys Lys Arg Lys Asp
    530                 535                 540                 
Arg Thr Arg Leu Lys Ser Ser Ser Leu Thr Phe Met Ser Thr Ser Ala
545                 550                 555                 560 
Arg Thr Arg Pro Leu Gln Ser Phe His Lys Arg Lys Leu Tyr Arg Leu
                565                 570                 575     
Ser Pro Thr Phe Tyr Trp Thr Pro Gln Thr Leu Pro Ser Lys Glu Thr
            580                 585                 590         
Ala Phe Leu Asn Thr Thr Gln Met Pro Cys Leu Gln Ser Ala Ser Thr
        595                 600                 605             
Trp Ser Ser Tyr Glu His Asn Ser Glu Ser Tyr Leu Leu Arg Glu His
    610                 615                 620                 
Val Ser Glu Leu Asp Ser Ser Phe His Ser Val Leu Ser Leu Pro Ser
625                 630                 635                 640 
Asp Val Pro Leu His Phe His Phe Glu Thr Leu Leu Lys Lys Thr Glu
                645                 650                 655     
Ile Lys Gly Asn Leu Ala Glu Asn Lys Phe Val Asp Glu Tyr Ile Ile
            660                 665                 670         
Ser Pro Ser Pro Val His Ser Thr Leu Asn Gln Trp Arg Asn Gly Tyr
        675                 680                 685             
Ser Pro Ile Cys Lys Pro Gln Ile Arg Ser Glu Ser Ser Ala Gln Leu
    690                 695                 700                 
Leu Gln Gly Arg Lys Lys Arg His Leu Ser Glu Thr Ala Leu Gly Glu
705                 710                 715                 720 
Arg Thr Lys Leu Glu Glu Ser Asp Phe Gln His Thr Glu Ser Gly Ser
                725                 730                 735     
His Ser Asn Phe Thr Ala Val Ser Asn Val Asn Val Leu Ser Arg Ile
            740                 745                 750         
Gln Asn Ser Ser Arg Asn Thr Ala Arg Arg Arg Leu Arg Ser Glu Ser
        755                 760                 765             
Ser Tyr Asp Ile Asp Asn Ile Val Ile Pro Met Ser Leu Val Ala Pro
    770                 775                 780                 
Ala Lys Leu Glu Lys Leu Gln Tyr Lys Glu Ile Leu Thr Pro Ser Trp
785                 790                 795                 800 
Arg Met Val Val Leu Gln Pro Leu Asp Glu Tyr Asn Leu Gly Lys Glu
                805                 810                 815     
Glu Ile Glu Asp Leu Ser Asp Glu Val Phe Ser Leu Arg His Lys Lys
            820                 825                 830         
Tyr Glu Glu Arg Glu Gln Ala Arg Trp Ser Leu Trp Glu Gln Ser Lys
        835                 840                 845             
Trp His Arg Arg Asn Ser Arg Ala Tyr Ser Lys Asn Val Glu Gly Gln
    850                 855                 860                 
Asp Leu Leu Leu Lys Glu Tyr Pro Asn Asn Phe Ser Ser Ser Gln Gln
865                 870                 875                 880 
Cys Ala Ala Ala Ser Pro Pro Gly Leu Pro Ser Glu Asn Gln Asp Leu
                885                 890                 895     
Cys Ala Tyr Gly Leu Pro Ser Leu Asn Gln Ser Gln Glu Thr Lys Ser
            900                 905                 910         
Leu Trp Trp Glu Arg Arg Ala Phe Pro Leu Lys Gly Glu Asp Met Ala
        915                 920                 925             
Ala Leu Leu Cys Gln Asp Glu Lys Lys Asp Gln Val Glu Arg Ser Ser
    930                 935                 940                 
Thr Ala Phe His Gly Glu Ile Phe Gly Thr Ser Val Pro Glu Asn Gly
945                 950                 955                 960 
His His Pro Lys Lys Gln Ser Asp Gly Met Glu Glu Tyr Lys Thr Phe
                965                 970                 975     
Gly Leu Gly Leu Thr Asn Val Lys Lys Asn Arg
            980                 985         


<210> 6664
<211> 1003
<212> PRT
<213> Homo sapiens

<400> 6664
Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro
 1               5                  10                  15      
Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly
            20                  25                  30          
Ala Val Leu Tyr Ile Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu
        35                  40                  45              
Gln Thr Arg Ser Tyr Leu Leu Ser Asp Gly Thr Cys Lys Cys Gly Leu
    50                  55                  60                  
Glu Cys Pro Leu Asn Val Pro Lys Val Phe Asn Phe Asp Pro Leu Ala
65                  70                  75                  80  
Pro Val Thr Pro Gly Gly Ala Gly Val Gly Pro Ala Ser Glu Glu Asp
                85                  90                  95      
Met Thr Lys Leu Cys Asn His Arg Arg Lys Ala Val Ala Met Ala Thr
            100                 105                 110         
Leu Tyr Arg Ser Met Glu Thr Thr Cys Ser His Ser Ser Pro Gly Glu
        115                 120                 125             
Gly Ala Ser Pro Gln Met Phe His Thr Val Ser Pro Gly Pro Pro Ser
    130                 135                 140                 
Ala Arg Pro Pro Cys Arg Val Pro Pro Thr Thr Pro Leu Asn Gly Gly
145                 150                 155                 160 
Pro Gly Ser Leu Pro Pro Glu Pro Pro Ser Val Ser Gln Ala Phe Pro
                165                 170                 175     
Thr Leu Ala Gly Pro Gly Gly Leu Phe Pro Pro Arg Leu Ala Asp Pro
            180                 185                 190         
Val Pro Ser Gly Gly Ser Ser Ser Pro Arg Phe Leu Pro Arg Gly Asn
        195                 200                 205             
Ala Pro Ser Pro Ala Pro Pro Pro Pro Pro Ala Ile Ser Leu Asn Ala
    210                 215                 220                 
Pro Ser Tyr Asn Trp Gly Ala Ala Leu Arg Ser Ser Leu Val Pro Ser
225                 230                 235                 240 
Asp Leu Gly Ser Pro Pro Ala Pro His Ala Ser Ser Ser Pro Pro Ser
                245                 250                 255     
Asp Pro Pro Leu Phe His Cys Ser Asp Ala Leu Thr Pro Pro Pro Leu
            260                 265                 270         
Pro Pro Ser Asn Asn Leu Pro Ala His Pro Gly Pro Ala Ser Gln Pro
        275                 280                 285             
Pro Val Ser Ser Ala Thr Met His Leu Pro Leu Val Leu Gly Pro Leu
    290                 295                 300                 
Gly Gly Ala Pro Thr Val Glu Gly Pro Gly Ala Pro Pro Phe Leu Ala
305                 310                 315                 320 
Ser Ser Leu Leu Ser Ala Ala Ala Lys Ala Gln His Pro Pro Leu Pro
                325                 330                 335     
Pro Pro Ser Thr Leu Gln Gly Arg Arg Pro Arg Ala Gln Ala Pro Ser
            340                 345                 350         
Ala Ser His Ser Ser Ser Leu Arg Pro Ser Gln Arg Arg Pro Arg Arg
        355                 360                 365             
Pro Pro Thr Val Phe Arg Leu Leu Glu Gly Arg Gly Pro Gln Thr Pro
    370                 375                 380                 
Arg Arg Ser Arg Pro Arg Ala Pro Ala Pro Val Pro Gln Pro Phe Ser
385                 390                 395                 400 
Leu Pro Glu Pro Ser Gln Pro Ile Leu Pro Ser Val Leu Ser Leu Leu
                405                 410                 415     
Gly Leu Pro Thr Pro Gly Pro Ser His Ser Asp Gly Ser Phe Asn Leu
            420                 425                 430         
Leu Gly Ser Asp Ala His Leu Pro Pro Pro Pro Thr Leu Ser Ser Gly
        435                 440                 445             
Ser Pro Pro Gln Pro Arg His Pro Ile Gln Pro Ser Leu Pro Gly Thr
    450                 455                 460                 
Thr Ser Gly Ser Leu Ser Ser Val Pro Gly Ala Pro Ala Pro Pro Ala
465                 470                 475                 480 
Ala Ser Lys Ala Pro Val Val Pro Ser Pro Val Leu Gln Ser Pro Ser
                485                 490                 495     
Glu Gly Leu Gly Met Gly Ala Gly Pro Ala Cys Pro Leu Pro Pro Leu
            500                 505                 510         
Ala Gly Gly Glu Ala Phe Pro Phe Pro Ser Pro Glu Gln Gly Leu Ala
        515                 520                 525             
Leu Ser Gly Ala Gly Phe Pro Gly Met Leu Gly Ala Leu Pro Leu Pro
    530                 535                 540                 
Leu Ser Leu Gly Gln Pro Pro Pro Ser Pro Leu Leu Asn His Ser Leu
545                 550                 555                 560 
Phe Gly Val Leu Thr Gly Gly Gly Gly Gln Pro Pro Pro Glu Pro Leu
                565                 570                 575     
Leu Pro Pro Pro Gly Gly Pro Gly Pro Pro Leu Ala Pro Gly Glu Pro
            580                 585                 590         
Glu Gly Pro Ser Leu Leu Val Ala Ser Leu Leu Pro Pro Pro Pro Ser
        595                 600                 605             
Asp Leu Leu Pro Pro Pro Ser Ala Pro Pro Ser Asn Leu Leu Ala Ser
    610                 615                 620                 
Phe Leu Pro Leu Leu Ala Leu Gly Pro Thr Ala Gly Asp Gly Glu Gly
625                 630                 635                 640 
Ser Ala Glu Gly Ala Gly Gly Pro Ser Gly Glu Pro Phe Ser Gly Leu
                645                 650                 655     
Gly Asp Leu Ser Pro Leu Leu Phe Pro Pro Leu Ser Ala Pro Pro Thr
            660                 665                 670         
Leu Ile Ala Leu Asn Ser Ala Leu Leu Ala Ala Thr Leu Asp Pro Pro
        675                 680                 685             
Ser Gly Thr Pro Pro Gln Pro Cys Val Leu Ser Ala Pro Gln Pro Gly
    690                 695                 700                 
Pro Pro Thr Ser Ser Val Thr Thr Ala Thr Thr Asp Pro Gly Ala Ser
705                 710                 715                 720 
Ser Leu Gly Lys Ala Pro Ser Asn Ser Gly Arg Pro Pro Gln Leu Leu
                725                 730                 735     
Ser Pro Leu Leu Gly Ala Ser Leu Leu Gly Asp Leu Ser Ser Leu Thr
            740                 745                 750         
Ser Ser Pro Gly Ala Leu Pro Ser Leu Leu Gln Pro Pro Gly Pro Leu
        755                 760                 765             
Leu Ser Gly Gln Leu Gly Leu Gln Leu Leu Pro Gly Gly Gly Ala Pro
    770                 775                 780                 
Pro Pro Leu Ser Glu Ala Ser Ser Pro Leu Ala Cys Leu Leu Gln Ser
785                 790                 795                 800 
Leu Gln Ile Pro Pro Glu Gln Pro Glu Ala Pro Cys Leu Pro Pro Glu
                805                 810                 815     
Ser Pro Ala Ser Ala Leu Glu Pro Glu Pro Ala Arg Pro Pro Leu Ser
            820                 825                 830         
Ala Leu Ala Pro Pro His Gly Ser Pro Asp Pro Pro Val Pro Glu Leu
        835                 840                 845             
Leu Thr Gly Arg Gly Ser Gly Lys Arg Gly Arg Arg Gly Gly Gly Gly
    850                 855                 860                 
Leu Arg Gly Ile Asn Gly Glu Ala Arg Pro Ala Arg Gly Arg Lys Pro
865                 870                 875                 880 
Gly Ser Arg Arg Glu Pro Gly Arg Leu Ala Leu Lys Trp Gly Thr Arg
                885                 890                 895     
Gly Gly Phe Asn Gly Gln Met Glu Arg Ser Pro Arg Arg Thr His His
            900                 905                 910         
Trp Gln His Asn Gly Glu Leu Ala Glu Gly Gly Ala Glu Pro Lys Asp
        915                 920                 925             
Pro Pro Pro Pro Gly Pro His Ser Glu Asp Leu Lys Val Pro Pro Gly
    930                 935                 940                 
Val Val Arg Lys Ser Arg Arg Gly Arg Arg Arg Lys Tyr Asn Pro Thr
945                 950                 955                 960 
Arg Asn Ser Asn Ser Ser Arg Gln Asp Ile Thr Leu Glu Pro Ser Pro
                965                 970                 975     
Thr Ala Arg Ala Ala Val Pro Leu Pro Pro Arg Ala Arg Pro Gly Arg
            980                 985                 990         
Pro Ala Lys Asn Lys Arg Arg Lys Leu Ala Pro
        995                 1000            


<210> 6665
<211> 4349
<212> PRT
<213> Homo sapiens

<400> 6665
Met Thr Ile Ala Leu Leu Gly Phe Ala Ile Phe Leu Leu His Cys Ala
 1               5                  10                  15      
Thr Cys Glu Lys Pro Leu Glu Gly Ile Leu Ser Ser Ser Ala Trp His
            20                  25                  30          
Phe Thr His Ser His Tyr Asn Ala Thr Ile Tyr Glu Asn Ser Ser Pro
        35                  40                  45              
Lys Thr Tyr Val Glu Ser Phe Glu Lys Met Gly Ile Tyr Leu Ala Glu
    50                  55                  60                  
Pro Gln Trp Ala Val Arg Tyr Arg Ile Ile Ser Gly Asp Val Ala Asn
65                  70                  75                  80  
Val Phe Lys Thr Glu Glu Tyr Val Val Gly Asn Phe Cys Phe Leu Arg
                85                  90                  95      
Ile Arg Thr Lys Ser Ser Asn Thr Ala Leu Leu Asn Arg Glu Val Arg
            100                 105                 110         
Asp Ser Tyr Thr Leu Ile Ile Gln Ala Thr Glu Lys Thr Leu Glu Leu
        115                 120                 125             
Glu Ala Leu Thr Arg Val Val Val His Ile Leu Asp Gln Asn Asp Leu
    130                 135                 140                 
Lys Pro Leu Phe Ser Pro Pro Ser Tyr Arg Val Thr Ile Ser Glu Asp
145                 150                 155                 160 
Met Pro Leu Lys Ser Pro Ile Cys Lys Val Thr Ala Thr Asp Ala Asp
                165                 170                 175     
Leu Gly Gln Asn Ala Glu Phe Tyr Tyr Ala Phe Asn Thr Arg Ser Glu
            180                 185                 190         
Met Phe Ala Ile His Pro Thr Ser Gly Val Val Thr Val Ala Gly Lys
        195                 200                 205             
Leu Asn Val Thr Trp Arg Gly Lys His Glu Leu Gln Val Leu Ala Val
    210                 215                 220                 
Asp Arg Met Arg Lys Ile Ser Glu Gly Asn Gly Phe Gly Ser Leu Ala
225                 230                 235                 240 
Ala Leu Val Val His Val Glu Pro Ala Leu Arg Lys Pro Pro Ala Ile
                245                 250                 255     
Ala Ser Val Val Val Thr Pro Pro Asp Ser Asn Asp Gly Thr Thr Tyr
            260                 265                 270         
Ala Thr Val Leu Val Asp Ala Asn Ser Ser Gly Ala Glu Val Glu Ser
        275                 280                 285             
Val Glu Val Val Gly Gly Asp Pro Gly Lys His Phe Lys Ala Ile Lys
    290                 295                 300                 
Ser Tyr Ala Arg Ser Asn Glu Phe Ser Leu Val Ser Val Lys Asp Ile
305                 310                 315                 320 
Asn Trp Met Glu Tyr Leu His Gly Phe Asn Leu Ser Leu Gln Ala Arg
                325                 330                 335     
Ser Gly Ser Gly Pro Tyr Phe Tyr Ser Gln Ile Arg Gly Phe His Leu
            340                 345                 350         
Pro Pro Ser Lys Leu Ser Ser Leu Lys Phe Glu Lys Ala Val Tyr Arg
        355                 360                 365             
Val Gln Leu Ser Glu Phe Ser Pro Pro Gly Ser Arg Val Val Met Val
    370                 375                 380                 
Arg Val Thr Pro Ala Phe Pro Asn Leu Gln Tyr Val Leu Lys Pro Ser
385                 390                 395                 400 
Ser Glu Asn Val Gly Phe Lys Leu Asn Ala Arg Thr Gly Leu Ile Thr
                405                 410                 415     
Thr Thr Lys Leu Met Asp Phe His Asp Arg Ala His Tyr Gln Leu His
            420                 425                 430         
Ile Arg Thr Ser Pro Gly Gln Ala Ser Thr Val Val Val Ile Asp Ile
        435                 440                 445             
Val Asp Cys Asn Asn His Ala Pro Leu Phe Asn Arg Ser Ser Tyr Asp
    450                 455                 460                 
Gly Thr Leu Asp Glu Asn Ile Pro Pro Gly Thr Ser Val Leu Ala Val
465                 470                 475                 480 
Thr Ala Thr Asp Arg Asp His Gly Glu Asn Gly Tyr Val Thr Tyr Ser
                485                 490                 495     
Ile Ala Gly Pro Lys Ala Leu Pro Phe Ser Ile Asp Pro Tyr Leu Gly
            500                 505                 510         
Ile Ile Ser Thr Ser Lys Pro Met Asp Tyr Glu Leu Met Lys Arg Ile
        515                 520                 525             
Tyr Thr Phe Arg Val Arg Ala Ser Asp Trp Gly Ser Pro Phe Arg Arg
    530                 535                 540                 
Glu Lys Glu Val Ser Ile Phe Leu Gln Leu Arg Asn Leu Asn Asp Asn
545                 550                 555                 560 
Gln Pro Met Phe Glu Glu Val Asn Cys Thr Gly Ser Ile Arg Gln Asp
                565                 570                 575     
Trp Pro Val Gly Lys Ser Ile Met Thr Met Ser Ala Ile Asp Val Asp
            580                 585                 590         
Glu Leu Gln Asn Leu Lys Tyr Glu Ile Val Ser Gly Asn Glu Leu Glu
        595                 600                 605             
Tyr Phe Asp Leu Asn His Phe Ser Gly Val Ile Ser Leu Lys Arg Pro
    610                 615                 620                 
Phe Ile Asn Leu Thr Ala Gly Gln Pro Thr Ser Tyr Ser Leu Lys Ile
625                 630                 635                 640 
Thr Ala Ser Asp Gly Lys Asn Tyr Ala Ser Pro Thr Thr Leu Asn Ile
                645                 650                 655     
Thr Val Val Lys Asp Pro His Phe Glu Val Pro Val Thr Cys Asp Lys
            660                 665                 670         
Thr Gly Val Leu Thr Gln Phe Thr Lys Thr Ile Leu His Phe Ile Gly
        675                 680                 685             
Leu Gln Asn Gln Glu Ser Ser Asp Glu Glu Phe Thr Ser Leu Ser Thr
    690                 695                 700                 
Tyr Gln Ile Asn His Tyr Thr Pro Gln Phe Glu Asp His Phe Pro Gln
705                 710                 715                 720 
Ser Ile Asp Val Leu Glu Ser Val Pro Ile Asn Thr Pro Leu Ala Arg
                725                 730                 735     
Leu Ala Ala Thr Asp Pro Asp Ala Gly Phe Asn Gly Lys Leu Val Tyr
            740                 745                 750         
Val Ile Ala Asp Gly Asn Glu Glu Gly Cys Phe Asp Ile Glu Leu Glu
        755                 760                 765             
Thr Gly Leu Leu Thr Val Ala Ala Pro Leu Asp Tyr Glu Ala Thr Asn
    770                 775                 780                 
Phe Tyr Ile Leu Asn Val Thr Val Tyr Asp Leu Gly Thr Pro Gln Lys
785                 790                 795                 800 
Ser Ser Trp Lys Leu Leu Thr Val Asn Val Lys Asp Trp Asn Asp Asn
                805                 810                 815     
Ala Pro Arg Phe Pro Pro Gly Gly Tyr Gln Leu Thr Ile Ser Glu Asp
            820                 825                 830         
Thr Glu Val Gly Thr Thr Ile Ala Glu Leu Thr Thr Lys Asp Ala Asp
        835                 840                 845             
Ser Glu Asp Asn Gly Arg Val Arg Tyr Thr Leu Leu Ser Pro Thr Glu
    850                 855                 860                 
Lys Phe Ser Leu His Pro Leu Thr Gly Glu Leu Val Val Thr Gly His
865                 870                 875                 880 
Leu Asp Arg Glu Ser Glu Pro Arg Tyr Ile Leu Lys Val Glu Ala Arg
                885                 890                 895     
Asp Gln Pro Ser Lys Gly His Gln Leu Phe Ser Val Thr Asp Leu Ile
            900                 905                 910         
Ile Thr Leu Glu Asp Val Asn Asp Asn Ser Pro Gln Cys Ile Thr Glu
        915                 920                 925             
His Asn Arg Leu Lys Val Pro Glu Asp Leu Pro Pro Gly Thr Val Leu
    930                 935                 940                 
Thr Phe Leu Asp Ala Ser Asp Pro Asp Leu Gly Pro Ala Gly Glu Val
945                 950                 955                 960 
Arg Tyr Val Leu Met Asp Gly Ala His Gly Thr Phe Arg Val Asp Leu
                965                 970                 975     
Met Thr Gly Ala Leu Ile Leu Glu Arg Glu Leu Asp Phe Glu Arg Arg
            980                 985                 990         
Ala Gly Tyr Asn Leu Ser Leu Trp Ala Ser Asp Gly Gly Arg Pro Leu
        995                 1000                1005            
Ala Arg Arg Thr Leu Cys His Val Glu Val Ile Val Leu Asp Val Asn
    1010                1015                1020                
Glu Asn Leu His Pro Pro His Phe Ala Ser Phe Val His Gln Gly Gln
1025                1030                1035                1040
Val Gln Glu Asn Ser Pro Ser Gly Thr Gln Val Ile Val Val Ala Ala
                1045                1050                1055    
Gln Asp Asp Asp Ser Gly Leu Asp Gly Glu Leu Gln Tyr Phe Leu Arg
            1060                1065                1070        
Ala Gly Thr Gly Leu Ala Ala Phe Ser Ile Asn Gln Asp Thr Gly Met
        1075                1080                1085            
Ile Gln Thr Leu Ala Pro Leu Asp Arg Glu Phe Ala Ser Tyr Tyr Trp
    1090                1095                1100                
Leu Thr Val Leu Ala Val Asp Arg Gly Ser Val Pro Leu Ser Ser Val
1105                1110                1115                1120
Thr Glu Val Tyr Ile Glu Val Thr Asp Ala Asn Asp Asn Pro Pro Gln
                1125                1130                1135    
Met Ser Gln Ala Val Phe Tyr Pro Ser Ile Gln Glu Asp Ala Pro Val
            1140                1145                1150        
Gly Thr Ser Val Leu Gln Leu Asp Ala Trp Asp Pro Asp Ser Ser Ser
        1155                1160                1165            
Lys Gly Lys Leu Thr Phe Asn Ile Thr Ser Gly Asn Tyr Met Gly Phe
    1170                1175                1180                
Phe Met Ile His Pro Val Thr Gly Leu Leu Ser Thr Ala Gln Gln Leu
1185                1190                1195                1200
Asp Arg Glu Asn Lys Asp Glu His Ile Leu Glu Val Thr Val Leu Asp
                1205                1210                1215    
Asn Gly Glu Pro Ser Leu Lys Ser Thr Ser Arg Val Val Val Gly Ile
            1220                1225                1230        
Leu Asp Val Asn Asp Asn Pro Pro Ile Phe Ser His Lys Leu Phe Asn
        1235                1240                1245            
Val Arg Leu Pro Glu Arg Leu Ser Pro Val Ser Pro Gly Pro Val Tyr
    1250                1255                1260                
Arg Leu Val Ala Ser Asp Leu Asp Glu Gly Leu Asn Gly Arg Val Thr
1265                1270                1275                1280
Tyr Ser Ile Glu Asp Ser Tyr Glu Glu Ala Phe Ser Ile Asp Leu Val
                1285                1290                1295    
Thr Gly Val Val Ser Ser Asn Ser Thr Phe Thr Ala Gly Glu Tyr Asn
            1300                1305                1310        
Ile Leu Thr Ile Lys Ala Thr Asp Ser Gly Gln Pro Pro Leu Ser Ala
        1315                1320                1325            
Ser Val Arg Leu His Ile Glu Trp Ile Pro Trp Pro Arg Pro Ser Ser
    1330                1335                1340                
Ile Pro Leu Ala Phe Asp Glu Thr Tyr Tyr Ser Phe Thr Val Met Glu
1345                1350                1355                1360
Thr Asp Pro Val Asn His Met Val Gly Val Ile Ser Val Glu Gly Arg
                1365                1370                1375    
Pro Gly Leu Phe Trp Phe Asn Ile Ser Gly Gly Asp Lys Asp Met Asp
            1380                1385                1390        
Phe Asp Ile Glu Lys Thr Thr Gly Ser Ile Val Ile Ala Arg Pro Leu
        1395                1400                1405            
Asp Thr Arg Arg Arg Ser Asn Tyr Asn Leu Thr Val Glu Val Thr Asp
    1410                1415                1420                
Gly Ser Arg Thr Ile Ala Thr Gln Val His Ile Phe Met Ile Ala Asn
1425                1430                1435                1440
Ile Asn His His Arg Pro Gln Phe Leu Glu Thr Arg Tyr Glu Val Arg
                1445                1450                1455    
Val Pro Gln Asp Thr Val Pro Gly Val Glu Leu Leu Arg Val Gln Ala
            1460                1465                1470        
Ile Asp Gln Asp Lys Gly Lys Ser Leu Ile Tyr Thr Ile His Gly Ser
        1475                1480                1485            
Gln Asp Pro Gly Ser Ala Ser Leu Phe Gln Leu Asp Pro Ser Ser Gly
    1490                1495                1500                
Val Leu Val Thr Val Gly Lys Leu Asp Leu Gly Ser Gly Pro Ser Gln
1505                1510                1515                1520
His Thr Leu Thr Val Met Val Arg Asp Gln Glu Ile Pro Ile Lys Arg
                1525                1530                1535    
Asn Phe Val Trp Val Thr Ile His Val Glu Asp Gly Asn Leu His Pro
            1540                1545                1550        
Pro Arg Phe Thr Gln Leu His Tyr Glu Ala Ser Val Pro Asp Thr Ile
        1555                1560                1565            
Ala Pro Gly Thr Glu Leu Leu Gln Val Arg Ala Met Asp Ala Asp Arg
    1570                1575                1580                
Gly Val Asn Ala Glu Val His Tyr Ser Leu Leu Lys Gly Asn Ser Glu
1585                1590                1595                1600
Gly Phe Phe Asn Ile Asn Ala Leu Leu Gly Ile Ile Thr Leu Ala Gln
                1605                1610                1615    
Lys Leu Asp Gln Ala Asn His Ala Pro His Thr Leu Thr Val Lys Ala
            1620                1625                1630        
Glu Asp Gln Gly Ser Pro Gln Trp His Asp Leu Ala Thr Val Ile Ile
        1635                1640                1645            
His Val Tyr Pro Ser Asp Arg Ser Ala Pro Ile Phe Ser Lys Ser Glu
    1650                1655                1660                
Tyr Phe Val Glu Ile Pro Glu Ser Ile Pro Val Gly Ser Pro Ile Leu
1665                1670                1675                1680
Leu Val Ser Ala Met Ser Pro Ser Glu Val Thr Tyr Glu Leu Arg Glu
                1685                1690                1695    
Gly Asn Lys Asp Gly Val Phe Ser Met Asn Ser Tyr Ser Gly Leu Ile
            1700                1705                1710        
Ser Thr Gln Lys Lys Leu Asp His Glu Lys Ile Ser Ser Tyr Gln Leu
        1715                1720                1725            
Lys Ile Arg Gly Ser Asn Met Ala Gly Ala Phe Thr Asp Val Met Val
    1730                1735                1740                
Val Val Asp Ile Ile Asp Glu Asn Asp Asn Ala Pro Met Phe Leu Lys
1745                1750                1755                1760
Ser Thr Phe Val Gly Gln Ile Ser Glu Ala Ala Pro Leu Tyr Ser Met
                1765                1770                1775    
Ile Met Asp Lys Asn Asn Asn Pro Phe Val Ile His Ala Ser Asp Ser
            1780                1785                1790        
Asp Lys Glu Ala Asn Ser Leu Leu Val Tyr Lys Ile Leu Glu Pro Glu
        1795                1800                1805            
Ala Leu Lys Phe Phe Lys Ile Asp Pro Ser Met Gly Thr Leu Thr Ile
    1810                1815                1820                
Val Ser Glu Met Asp Tyr Glu Ser Met Pro Ser Phe Gln Phe Cys Val
1825                1830                1835                1840
Tyr Val His Asp Gln Gly Ser Pro Val Leu Phe Ala Pro Arg Pro Ala
                1845                1850                1855    
Gln Val Ile Ile His Val Arg Asp Val Asn Asp Ser Pro Pro Arg Phe
            1860                1865                1870        
Ser Glu Gln Ile Tyr Glu Val Ala Ile Val Gly Pro Ile His Pro Gly
        1875                1880                1885            
Met Glu Leu Leu Met Val Arg Ala Ser Asp Glu Asp Ser Glu Val Asn
    1890                1895                1900                
Tyr Ser Ile Lys Thr Gly Asn Ala Asp Glu Ala Val Thr Ile His Pro
1905                1910                1915                1920
Val Thr Gly Ser Ile Ser Val Leu Asn Pro Ala Phe Leu Gly Leu Ser
                1925                1930                1935    
Arg Lys Leu Thr Ile Arg Ala Ser Asp Gly Leu Tyr Gln Asp Thr Ala
            1940                1945                1950        
Leu Val Lys Ile Ser Leu Thr Gln Val Leu Asp Lys Ser Leu Gln Phe
        1955                1960                1965            
Asp Gln Asp Val Tyr Trp Ala Ala Val Lys Glu Asn Leu Gln Asp Arg
    1970                1975                1980                
Lys Ala Leu Val Ile Leu Gly Ala Gln Gly Asn His Leu Asn Asp Thr
1985                1990                1995                2000
Leu Ser Tyr Phe Leu Leu Asn Gly Thr Asp Met Phe His Met Val Gln
                2005                2010                2015    
Ser Ala Gly Val Leu Gln Thr Arg Gly Val Ala Phe Asp Arg Glu Gln
            2020                2025                2030        
Gln Asp Thr His Glu Leu Ala Val Glu Val Arg Asp Asn Arg Thr Pro
        2035                2040                2045            
Gln Arg Val Ala Gln Gly Leu Val Arg Val Ser Ile Glu Asp Val Asn
    2050                2055                2060                
Asp Asn Pro Pro Lys Phe Lys His Leu Pro Tyr Tyr Thr Ile Ile Gln
2065                2070                2075                2080
Asp Gly Thr Glu Pro Gly Asp Val Leu Phe Gln Val Ser Ala Thr Asp
                2085                2090                2095    
Glu Asp Leu Gly Thr Asn Gly Ala Val Thr Tyr Glu Phe Ala Glu Asp
            2100                2105                2110        
Tyr Thr Tyr Phe Arg Ile Asp Pro Tyr Leu Gly Asp Ile Ser Leu Lys
        2115                2120                2125            
Lys Pro Phe Asp Tyr Gln Ala Leu Asn Lys Tyr His Leu Lys Val Ile
    2130                2135                2140                
Ala Arg Asp Gly Gly Thr Pro Ser Leu Gln Ser Glu Glu Glu Val Leu
2145                2150                2155                2160
Val Thr Val Arg Asn Lys Ser Asn Pro Leu Phe Gln Ser Pro Tyr Tyr
                2165                2170                2175    
Lys Val Arg Val Pro Glu Asn Ile Thr Leu Tyr Thr Pro Ile Leu His
            2180                2185                2190        
Thr Gln Ala Arg Ser Pro Glu Gly Leu Arg Leu Ile Tyr Asn Ile Val
        2195                2200                2205            
Glu Glu Glu Pro Leu Met Leu Phe Thr Thr Asp Phe Lys Thr Gly Val
    2210                2215                2220                
Leu Thr Val Thr Gly Pro Leu Asp Tyr Glu Ser Lys Thr Lys His Val
2225                2230                2235                2240
Phe Thr Val Arg Ala Thr Asp Thr Ala Leu Gly Ser Phe Ser Glu Ala
                2245                2250                2255    
Thr Val Glu Val Leu Val Glu Asp Val Asn Asp Asn Pro Pro Thr Phe
            2260                2265                2270        
Ser Gln Leu Val Tyr Thr Thr Ser Ile Ser Glu Gly Leu Pro Ala Gln
        2275                2280                2285            
Thr Pro Val Ile Gln Leu Leu Ala Ser Asp Gln Asp Ser Gly Arg Asn
    2290                2295                2300                
Arg Asp Val Ser Tyr Gln Ile Val Glu Asp Gly Ser Asp Val Ser Lys
2305                2310                2315                2320
Phe Phe Gln Ile Asn Gly Ser Thr Gly Glu Met Ser Thr Val Gln Glu
                2325                2330                2335    
Leu Asp Tyr Glu Ala Gln Gln His Phe His Val Lys Val Arg Ala Met
            2340                2345                2350        
Asp Lys Gly Asp Pro Pro Leu Thr Gly Glu Thr Leu Val Val Val Asn
        2355                2360                2365            
Val Ser Asp Ile Asn Asp Asn Pro Pro Glu Phe Arg Gln Pro Gln Tyr
    2370                2375                2380                
Glu Ala Asn Val Ser Glu Leu Ala Thr Cys Gly His Leu Val Leu Lys
2385                2390                2395                2400
Val Gln Ala Ile Asp Pro Asp Ser Arg Asp Thr Ser Arg Leu Glu Tyr
                2405                2410                2415    
Leu Ile Leu Ser Gly Asn Gln Asp Arg His Phe Phe Ile Asn Ser Ser
            2420                2425                2430        
Ser Gly Ile Ile Ser Met Phe Asn Leu Cys Lys Lys His Leu Asp Ser
        2435                2440                2445            
Ser Tyr Asn Leu Arg Val Gly Ala Ser Asp Gly Val Phe Arg Ala Thr
    2450                2455                2460                
Val Pro Val Tyr Ile Asn Thr Thr Asn Ala Asn Lys Tyr Ser Pro Glu
2465                2470                2475                2480
Phe Gln Gln His Leu Tyr Glu Ala Glu Leu Ala Glu Asn Ala Met Val
                2485                2490                2495    
Gly Thr Lys Val Ile Asp Leu Leu Ala Ile Asp Lys Asp Ser Gly Pro
            2500                2505                2510        
Tyr Gly Thr Ile Asp Tyr Thr Ile Ile Asn Lys Leu Ala Ser Glu Lys
        2515                2520                2525            
Phe Ser Ile Asn Pro Asn Gly Gln Ile Ala Thr Leu Gln Lys Leu Asp
    2530                2535                2540                
Arg Glu Asn Ser Thr Glu Arg Val Ile Ala Ile Lys Val Met Ala Arg
2545                2550                2555                2560
Asp Gly Gly Gly Arg Val Ala Phe Cys Thr Val Lys Ile Ile Leu Thr
                2565                2570                2575    
Asp Glu Asn Asp Asn Pro Pro Gln Phe Lys Ala Ser Glu Tyr Thr Val
            2580                2585                2590        
Ser Ile Gln Ser Asn Val Ser Lys Asp Ser Pro Val Ile Gln Val Leu
        2595                2600                2605            
Ala Tyr Asp Ala Asp Glu Gly Gln Asn Ala Asp Val Thr Tyr Ser Val
    2610                2615                2620                
Asn Pro Glu Asp Leu Val Lys Asp Val Ile Glu Ile Asn Pro Val Thr
2625                2630                2635                2640
Gly Val Val Lys Val Lys Asp Ser Leu Val Gly Leu Glu Asn Gln Thr
                2645                2650                2655    
Leu Asp Phe Phe Ile Lys Ala Gln Asp Gly Gly Pro Pro His Trp Asn
            2660                2665                2670        
Ser Leu Val Pro Val Arg Leu Gln Val Val Pro Lys Lys Val Ser Leu
        2675                2680                2685            
Pro Lys Phe Ser Glu Pro Leu Tyr Thr Phe Ser Ala Pro Glu Asp Leu
    2690                2695                2700                
Pro Glu Gly Ser Glu Ile Gly Ile Val Lys Ala Val Ala Ala Gln Asp
2705                2710                2715                2720
Pro Val Ile Tyr Ser Leu Val Arg Gly Thr Thr Pro Glu Ser Asn Lys
                2725                2730                2735    
Asp Gly Val Phe Ser Leu Asp Pro Asp Thr Gly Val Ile Lys Val Arg
            2740                2745                2750        
Lys Pro Met Asp His Glu Ser Thr Lys Leu Tyr Gln Ile Asp Val Met
        2755                2760                2765            
Ala His Cys Leu Gln Asn Thr Asp Val Val Ser Leu Val Ser Val Asn
    2770                2775                2780                
Ile Gln Val Gly Asp Val Asn Asp Asn Arg Pro Val Phe Glu Ala Asp
2785                2790                2795                2800
Pro Tyr Lys Ala Val Leu Thr Glu Asn Met Pro Val Gly Thr Ser Val
                2805                2810                2815    
Ile Gln Val Thr Ala Ile Asp Lys Asp Thr Gly Arg Asp Gly Gln Val
            2820                2825                2830        
Ser Tyr Arg Leu Ser Ala Asp Pro Gly Ser Asn Val His Glu Leu Phe
        2835                2840                2845            
Ala Ile Asp Ser Glu Ser Gly Trp Ile Thr Thr Leu Gln Glu Leu Asp
    2850                2855                2860                
Cys Glu Thr Cys Gln Thr Tyr His Phe His Val Val Ala Tyr Asp His
2865                2870                2875                2880
Gly Gln Thr Ile Gln Leu Ser Ser Gln Ala Leu Val Gln Val Ser Ile
                2885                2890                2895    
Thr Asp Glu Asn Asp Asn Ala Pro Arg Phe Ala Ser Glu Glu Tyr Arg
            2900                2905                2910        
Gly Ser Val Val Glu Asn Ser Glu Pro Gly Glu Leu Val Ala Thr Leu
        2915                2920                2925            
Lys Thr Leu Asp Ala Asp Ile Ser Glu Gln Asn Arg Gln Val Thr Cys
    2930                2935                2940                
Tyr Ile Thr Glu Gly Asp Pro Leu Gly Gln Phe Gly Ile Ser Gln Val
2945                2950                2955                2960
Gly Asp Glu Trp Arg Ile Ser Ser Arg Lys Thr Leu Asp Arg Glu His
                2965                2970                2975    
Thr Ala Lys Tyr Leu Leu Arg Val Thr Ala Ser Asp Gly Lys Phe Gln
            2980                2985                2990        
Ala Ser Val Thr Val Glu Ile Phe Val Leu Asp Val Asn Asp Asn Ser
        2995                3000                3005            
Pro Gln Cys Ser Gln Leu Leu Tyr Thr Gly Lys Val His Glu Asp Val
    3010                3015                3020                
Phe Pro Gly His Phe Ile Leu Lys Val Ser Ala Thr Asp Leu Asp Thr
3025                3030                3035                3040
Asp Thr Asn Ala Gln Ile Thr Tyr Ser Leu His Gly Pro Gly Ala His
                3045                3050                3055    
Glu Phe Lys Leu Asp Pro His Thr Gly Glu Leu Thr Thr Leu Thr Ala
            3060                3065                3070        
Leu Asp Arg Glu Arg Lys Asp Val Phe Asn Leu Val Ala Lys Ala Thr
        3075                3080                3085            
Asp Gly Gly Gly Arg Ser Cys Gln Ala Asp Ile Thr Leu His Val Glu
    3090                3095                3100                
Asp Val Asn Asp Asn Ala Pro Arg Phe Phe Pro Ser His Cys Ala Val
3105                3110                3115                3120
Ala Val Phe Asp Asn Thr Thr Val Lys Thr Pro Val Ala Val Val Phe
                3125                3130                3135    
Ala Arg Asp Pro Asp Gln Gly Ala Asn Ala Gln Val Val Tyr Ser Leu
            3140                3145                3150        
Pro Asp Ser Ala Glu Gly His Phe Ser Ile Asp Ala Thr Thr Gly Val
        3155                3160                3165            
Ile Arg Leu Glu Lys Pro Leu Gln Val Arg Pro Gln Ala Pro Leu Glu
    3170                3175                3180                
Leu Thr Val Arg Ala Ser Asp Leu Gly Thr Pro Ile Pro Leu Ser Thr
3185                3190                3195                3200
Leu Gly Thr Val Thr Val Ser Val Val Gly Leu Glu Asp Tyr Leu Pro
                3205                3210                3215    
Val Phe Leu Asn Thr Glu His Ser Val Gln Val Pro Glu Asp Ala Pro
            3220                3225                3230        
Pro Gly Thr Glu Val Leu Gln Leu Ala Thr Leu Thr Arg Pro Gly Ala
        3235                3240                3245            
Glu Lys Thr Gly Tyr Arg Val Val Ser Gly Asn Glu Gln Gly Arg Phe
    3250                3255                3260                
Arg Leu Asp Ala Arg Thr Gly Ile Leu Tyr Val Asn Ala Ser Leu Asp
3265                3270                3275                3280
Phe Glu Thr Ser Pro Lys Tyr Phe Leu Ser Ile Glu Cys Ser Arg Lys
                3285                3290                3295    
Ser Ser Ser Ser Leu Ser Asp Val Thr Thr Val Met Val Asn Ile Thr
            3300                3305                3310        
Asp Val Asn Glu His Arg Pro Gln Phe Pro Gln Asp Pro Tyr Ser Thr
        3315                3320                3325            
Arg Val Leu Glu Asn Ala Leu Val Gly Asp Val Ile Leu Thr Val Ser
    3330                3335                3340                
Ala Thr Asp Glu Asp Gly Pro Leu Asn Ser Asp Ile Thr Tyr Ser Leu
3345                3350                3355                3360
Ile Gly Gly Asn Gln Leu Gly His Phe Thr Ile His Pro Lys Lys Gly
                3365                3370                3375    
Glu Leu Gln Val Ala Lys Ala Leu Asp Arg Glu Gln Ala Ser Ser Tyr
            3380                3385                3390        
Ser Leu Lys Leu Arg Ala Thr Asp Ser Gly Gln Pro Pro Leu His Glu
        3395                3400                3405            
Asp Thr Asp Ile Ala Ile Gln Val Ala Asp Val Asn Asp Asn Pro Pro
    3410                3415                3420                
Arg Phe Phe Gln Leu Asn Tyr Ser Thr Thr Val Gln Glu Asn Ser Pro
3425                3430                3435                3440
Ile Gly Ser Lys Val Leu Gln Leu Ile Leu Ser Asp Pro Asp Ser Pro
                3445                3450                3455    
Glu Asn Gly Pro Pro Tyr Ser Phe Arg Ile Thr Lys Gly Asn Asn Gly
            3460                3465                3470        
Ser Ala Phe Arg Val Thr Pro Asp Gly Trp Leu Val Thr Ala Glu Gly
        3475                3480                3485            
Leu Ser Arg Arg Ala Gln Glu Trp Tyr Gln Leu Gln Ile Gln Ala Ser
    3490                3495                3500                
Asp Ser Gly Ile Pro Pro Leu Ser Ser Leu Thr Ser Val Arg Val His
3505                3510                3515                3520
Val Thr Glu Gln Ser His Tyr Ala Pro Ser Ala Leu Pro Leu Glu Ile
                3525                3530                3535    
Phe Ile Thr Val Gly Glu Asp Glu Phe Gln Gly Gly Met Val Gly Lys
            3540                3545                3550        
Ile His Ala Thr Asp Arg Asp Pro Gln Asp Thr Leu Thr Tyr Ser Leu
        3555                3560                3565            
Ala Glu Glu Glu Thr Leu Gly Arg His Phe Ser Val Gly Ala Pro Asp
    3570                3575                3580                
Gly Lys Ile Ile Ala Ala Gln Gly Leu Pro Arg Gly His Tyr Ser Phe
3585                3590                3595                3600
Asn Val Thr Val Ser Asp Gly Thr Phe Thr Thr Thr Ala Gly Val His
                3605                3610                3615    
Val Tyr Val Trp His Val Gly Gln Glu Ala Leu Gln Gln Ala Met Trp
            3620                3625                3630        
Met Gly Phe Tyr Gln Leu Thr Pro Glu Glu Leu Val Ser Asp His Trp
        3635                3640                3645            
Arg Asn Leu Gln Arg Phe Leu Ser His Lys Leu Asp Ile Lys Arg Ala
    3650                3655                3660                
Asn Ile His Leu Ala Ser Leu Gln Pro Ala Glu Ala Val Ala Gly Val
3665                3670                3675                3680
Asp Val Leu Leu Val Phe Glu Gly His Ser Gly Thr Phe Tyr Glu Phe
                3685                3690                3695    
Gln Glu Leu Ala Ser Ile Ile Thr His Ser Ala Lys Glu Met Glu His
            3700                3705                3710        
Ser Val Gly Val Gln Met Arg Ser Ala Met Pro Met Val Pro Cys Gln
        3715                3720                3725            
Gly Pro Thr Cys Gln Gly Gln Ile Cys His Asn Thr Val His Leu Asp
    3730                3735                3740                
Pro Lys Val Gly Pro Thr Tyr Ser Thr Ala Arg Leu Ser Ile Leu Thr
3745                3750                3755                3760
Pro Arg His His Leu Gln Arg Ser Cys Ser Cys Asn Gly Thr Ala Thr
                3765                3770                3775    
Arg Phe Ser Gly Gln Ser Tyr Val Arg Tyr Arg Ala Pro Ala Ala Arg
            3780                3785                3790        
Asn Trp His Ile His Phe Tyr Leu Lys Thr Leu Gln Pro Gln Ala Ile
        3795                3800                3805            
Leu Leu Phe Thr Asn Glu Thr Ala Ser Val Ser Leu Lys Leu Ala Ser
    3810                3815                3820                
Gly Val Pro Gln Leu Glu Tyr His Cys Leu Gly Gly Phe Tyr Gly Asn
3825                3830                3835                3840
Leu Ser Ser Gln Arg His Val Asn Asp His Glu Trp His Ser Ile Leu
                3845                3850                3855    
Val Glu Glu Met Asp Ala Ser Ile Arg Leu Met Val Asp Ser Met Gly
            3860                3865                3870        
Asn Thr Ser Leu Val Val Pro Glu Asn Cys Arg Gly Leu Arg Pro Glu
        3875                3880                3885            
Arg His Leu Leu Leu Gly Gly Leu Ile Leu Leu His Ser Ser Ser Asn
    3890                3895                3900                
Val Ser Gln Gly Phe Glu Gly Cys Leu Asp Ala Val Val Val Asn Glu
3905                3910                3915                3920
Glu Ala Leu Asp Leu Leu Ala Pro Gly Lys Thr Val Ala Gly Leu Leu
                3925                3930                3935    
Glu Thr Gln Ala Leu Thr Gln Cys Cys Leu His Ser Asp Tyr Cys Ser
            3940                3945                3950        
Gln Asn Thr Cys Leu Asn Gly Gly Lys Cys Ser Trp Thr His Gly Ala
        3955                3960                3965            
Gly Tyr Val Cys Lys Cys Pro Pro Gln Phe Ser Gly Lys His Cys Glu
    3970                3975                3980                
Gln Gly Arg Glu Asn Cys Thr Phe Ala Pro Cys Leu Glu Gly Gly Thr
3985                3990                3995                4000
Cys Ile Leu Ser Pro Lys Gly Ala Ser Cys Asn Cys Pro His Pro Tyr
                4005                4010                4015    
Thr Gly Asp Arg Cys Glu Met Glu Ala Arg Gly Cys Ser Glu Gly His
            4020                4025                4030        
Cys Leu Val Thr Pro Glu Ile Gln Arg Gly Asp Trp Gly Gln Gln Glu
        4035                4040                4045            
Leu Leu Ile Ile Thr Val Ala Val Ala Phe Ile Ile Ile Ser Thr Val
    4050                4055                4060                
Gly Leu Leu Phe Tyr Cys Arg Arg Cys Lys Ser His Lys Pro Val Ala
4065                4070                4075                4080
Met Glu Asp Pro Asp Leu Leu Ala Arg Ser Val Gly Val Asp Thr Gln
                4085                4090                4095    
Ala Met Pro Ala Ile Glu Leu Asn Pro Leu Ser Ala Ser Ser Cys Asn
            4100                4105                4110        
Asn Leu Asn Gln Pro Glu Pro Ser Lys Ala Ser Val Pro Asn Glu Leu
        4115                4120                4125            
Val Thr Phe Gly Pro Asn Ser Lys Gln Arg Pro Val Val Cys Ser Val
    4130                4135                4140                
Pro Pro Arg Leu Pro Pro Ala Ala Val Pro Ser His Ser Asp Asn Glu
4145                4150                4155                4160
Pro Val Ile Lys Arg Thr Trp Ser Ser Glu Glu Met Val Tyr Pro Gly
                4165                4170                4175    
Gly Ala Met Val Trp Pro Pro Thr Tyr Ser Arg Asn Glu Arg Trp Glu
            4180                4185                4190        
Tyr Pro His Ser Glu Val Thr Gln Gly Pro Leu Pro Pro Ser Ala His
        4195                4200                4205            
Arg His Ser Thr Pro Val Val Met Pro Glu Pro Asn Gly Leu Tyr Gly
    4210                4215                4220                
Gly Phe Pro Phe Pro Leu Glu Met Glu Asn Lys Arg Ala Pro Leu Pro
4225                4230                4235                4240
Pro Arg Tyr Ser Asn Gln Asn Leu Glu Asp Leu Met Pro Ser Arg Pro
                4245                4250                4255    
Pro Ser Pro Arg Glu Arg Leu Val Ala Pro Cys Leu Asn Glu Tyr Thr
            4260                4265                4270        
Ala Ile Ser Tyr Tyr His Ser Gln Phe Arg Gln Gly Gly Gly Gly Pro
        4275                4280                4285            
Cys Leu Ala Asp Gly Gly Tyr Lys Gly Val Gly Met Arg Leu Ser Arg
    4290                4295                4300                
Ala Gly Pro Ser Tyr Ala Val Cys Glu Val Glu Gly Ala Pro Leu Ala
4305                4310                4315                4320
Gly Gln Gly Gln Pro Arg Val Pro Pro Asn Tyr Glu Gly Ser Asp Met
                4325                4330                4335    
Val Glu Ser Asp Tyr Gly Ser Cys Glu Glu Val Met Phe
            4340                4345                


<210> 6666
<211> 2214
<212> PRT
<213> Homo sapiens

<400> 6666
Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe
 1               5                  10                  15      
Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr
            20                  25                  30          
Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe
        35                  40                  45              
Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly
    50                  55                  60                  
Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys
65                  70                  75                  80  
Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val
                85                  90                  95      
Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu
            100                 105                 110         
Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala
        115                 120                 125             
Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser
    130                 135                 140                 
Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser
145                 150                 155                 160 
Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg
                165                 170                 175     
Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp
            180                 185                 190         
Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp
        195                 200                 205             
Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg
    210                 215                 220                 
Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr
225                 230                 235                 240 
Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp
                245                 250                 255     
Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser
            260                 265                 270         
Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu
        275                 280                 285             
Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp
    290                 295                 300                 
Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln
305                 310                 315                 320 
Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg
                325                 330                 335     
Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala
            340                 345                 350         
Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn
        355                 360                 365             
Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu
    370                 375                 380                 
Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp
385                 390                 395                 400 
Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg
                405                 410                 415     
Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser
            420                 425                 430         
Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly
        435                 440                 445             
Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys
    450                 455                 460                 
Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg
465                 470                 475                 480 
Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser
                485                 490                 495     
Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys
            500                 505                 510         
Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala
        515                 520                 525             
Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp
    530                 535                 540                 
His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu
545                 550                 555                 560 
Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe
                565                 570                 575     
Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu
            580                 585                 590         
Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His
        595                 600                 605             
Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro
    610                 615                 620                 
Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly
625                 630                 635                 640 
Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro
                645                 650                 655     
His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val
            660                 665                 670         
Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe
        675                 680                 685             
Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu
    690                 695                 700                 
Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser
705                 710                 715                 720 
Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys
                725                 730                 735     
Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys
            740                 745                 750         
Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser
        755                 760                 765             
Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu
    770                 775                 780                 
Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn
785                 790                 795                 800 
Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys
                805                 810                 815     
Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu
            820                 825                 830         
Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp
        835                 840                 845             
Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp
    850                 855                 860                 
Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala
865                 870                 875                 880 
Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly
                885                 890                 895     
Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala
            900                 905                 910         
Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val
        915                 920                 925             
Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu
    930                 935                 940                 
Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu
945                 950                 955                 960 
Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp
                965                 970                 975     
Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser
            980                 985                 990         
Gln Met Glu Ile Leu Ala Asn Gln Leu Thr Gly Leu Met Asp Met Lys
        995                 1000                1005            
Ile Phe Tyr Lys Gly Lys Asn Thr Gly Ser Asn Ala Cys Val Pro Arg
    1010                1015                1020                
Pro Cys Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser Cys
1025                1030                1035                1040
Arg Cys Pro Glu Asp Val Ser Ser Ser Val Leu Pro Ser Gly Asp Leu
                1045                1050                1055    
Met Cys Asp Cys Pro Gln Gly Tyr Gln Leu Lys Asn Asn Thr Cys Val
            1060                1065                1070        
Lys Glu Glu Asn Thr Cys Leu Arg Asn Gln Tyr Arg Cys Ser Asn Gly
        1075                1080                1085            
Asn Cys Ile Asn Ser Ile Trp Trp Cys Asp Phe Asp Asn Asp Cys Gly
    1090                1095                1100                
Asp Met Ser Asp Glu Arg Asn Cys Pro Thr Thr Ile Cys Asp Leu Asp
1105                1110                1115                1120
Thr Gln Phe Arg Cys Gln Glu Ser Gly Thr Cys Ile Pro Leu Ser Tyr
                1125                1130                1135    
Lys Cys Asp Leu Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu Ser His
            1140                1145                1150        
Cys Glu Met His Gln Cys Arg Ser Asp Glu Tyr Asn Cys Ser Ser Gly
        1155                1160                1165            
Met Cys Ile Arg Ser Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Arg
    1170                1175                1180                
Asp Trp Ser Asp Glu Ala Asn Cys Thr Ala Ile Tyr His Thr Cys Glu
1185                1190                1195                1200
Ala Ser Asn Phe Gln Cys Arg Asn Gly His Cys Ile Pro Gln Arg Trp
                1205                1210                1215    
Ala Cys Asp Gly Asp Thr Asp Cys Gln Asp Gly Ser Asp Glu Asp Pro
            1220                1225                1230        
Val Asn Cys Glu Lys Lys Cys Asn Gly Phe Arg Cys Pro Asn Gly Thr
        1235                1240                1245            
Cys Ile Pro Ser Ser Lys His Cys Asp Gly Leu Arg Asp Cys Ser Asp
    1250                1255                1260                
Gly Ser Asp Glu Gln His Cys Glu Pro Leu Cys Thr His Phe Met Asp
1265                1270                1275                1280
Phe Val Cys Lys Asn Arg Gln Gln Cys Leu Phe His Ser Met Val Cys
                1285                1290                1295    
Asp Gly Ile Ile Gln Cys Arg Asp Gly Ser Asp Glu Asp Ala Ala Phe
            1300                1305                1310        
Ala Gly Cys Ser Gln Asp Pro Glu Phe His Lys Val Cys Asp Glu Phe
        1315                1320                1325            
Gly Phe Gln Cys Gln Asn Gly Val Cys Ile Ser Leu Ile Trp Lys Cys
    1330                1335                1340                
Asp Gly Met Asp Asp Cys Gly Asp Tyr Ser Asp Glu Ala Asn Cys Glu
1345                1350                1355                1360
Asn Pro Thr Glu Ala Pro Asn Cys Ser Arg Tyr Phe Gln Phe Arg Cys
                1365                1370                1375    
Glu Asn Gly His Cys Ile Pro Asn Arg Trp Lys Cys Asp Arg Glu Asn
            1380                1385                1390        
Asp Cys Gly Asp Trp Ser Asp Glu Lys Asp Cys Gly Asp Ser His Ile
        1395                1400                1405            
Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Cys Leu Pro Asn Tyr Tyr
    1410                1415                1420                
Arg Cys Ser Ser Gly Thr Cys Val Met Asp Thr Trp Val Cys Asp Gly
1425                1430                1435                1440
Tyr Arg Asp Cys Ala Asp Gly Ser Asp Glu Glu Ala Cys Pro Leu Leu
                1445                1450                1455    
Ala Asn Val Thr Ala Ala Ser Thr Pro Thr Gln Leu Gly Arg Cys Asp
            1460                1465                1470        
Arg Phe Glu Phe Glu Cys His Gln Pro Lys Thr Cys Ile Pro Asn Trp
        1475                1480                1485            
Lys Arg Cys Asp Gly His Gln Asp Cys Gln Asp Gly Arg Asp Glu Ala
    1490                1495                1500                
Asn Cys Pro Thr His Ser Thr Leu Thr Cys Met Ser Arg Glu Phe Gln
1505                1510                1515                1520
Cys Glu Asp Gly Glu Ala Cys Ile Val Leu Ser Glu Arg Cys Asp Gly
                1525                1530                1535    
Phe Leu Asp Cys Ser Asp Glu Ser Asp Glu Lys Ala Cys Ser Asp Glu
            1540                1545                1550        
Leu Thr Val Tyr Lys Val Gln Asn Leu Gln Trp Thr Ala Asp Phe Ser
        1555                1560                1565            
Gly Asp Val Thr Leu Thr Trp Met Arg Pro Lys Lys Met Pro Ser Ala
    1570                1575                1580                
Ser Cys Val Tyr Asn Val Tyr Tyr Arg Val Val Gly Glu Ser Ile Trp
1585                1590                1595                1600
Lys Thr Leu Glu Thr His Ser Asn Lys Thr Asn Thr Val Leu Lys Val
                1605                1610                1615    
Leu Lys Pro Asp Thr Thr Tyr Gln Val Lys Val Gln Val Gln Cys Leu
            1620                1625                1630        
Ser Lys Ala His Asn Thr Asn Asp Phe Val Thr Leu Arg Thr Pro Glu
        1635                1640                1645            
Gly Leu Pro Asp Ala Pro Arg Asn Leu Gln Leu Ser Leu Pro Arg Glu
    1650                1655                1660                
Ala Glu Gly Val Ile Val Gly His Trp Ala Pro Pro Ile His Thr His
1665                1670                1675                1680
Gly Leu Ile Arg Glu Tyr Ile Val Glu Tyr Ser Arg Ser Gly Ser Lys
                1685                1690                1695    
Met Trp Ala Ser Gln Arg Ala Ala Ser Asn Phe Thr Glu Ile Lys Asn
            1700                1705                1710        
Leu Leu Val Asn Thr Leu Tyr Thr Val Arg Val Ala Ala Val Thr Ser
        1715                1720                1725            
Arg Gly Ile Gly Asn Trp Ser Asp Ser Lys Ser Ile Thr Thr Ile Lys
    1730                1735                1740                
Gly Lys Val Ile Pro Pro Pro Asp Ile His Ile Asp Ser Tyr Gly Glu
1745                1750                1755                1760
Asn Tyr Leu Ser Phe Thr Leu Thr Met Glu Ser Asp Ile Lys Val Asn
                1765                1770                1775    
Gly Tyr Val Val Asn Leu Phe Trp Ala Phe Asp Thr His Lys Gln Glu
            1780                1785                1790        
Arg Arg Thr Leu Asn Phe Arg Gly Ser Ile Leu Ser His Lys Val Gly
        1795                1800                1805            
Asn Leu Thr Ala His Thr Ser Tyr Glu Ile Ser Ala Trp Ala Lys Thr
    1810                1815                1820                
Asp Leu Gly Asp Ser Pro Leu Ala Phe Glu His Val Met Thr Arg Gly
1825                1830                1835                1840
Val Arg Pro Pro Ala Pro Ser Leu Lys Ala Lys Ala Ile Asn Gln Thr
                1845                1850                1855    
Ala Val Glu Cys Thr Trp Thr Gly Pro Arg Asn Val Val Tyr Gly Ile
            1860                1865                1870        
Phe Tyr Ala Thr Ser Phe Leu Asp Leu Tyr Arg Asn Pro Lys Ser Leu
        1875                1880                1885            
Thr Thr Ser Leu His Asn Lys Thr Val Ile Val Ser Lys Asp Glu Gln
    1890                1895                1900                
Tyr Leu Phe Leu Val Arg Val Val Val Pro Tyr Gln Gly Pro Ser Ser
1905                1910                1915                1920
Asp Tyr Val Val Val Lys Met Ile Pro Asp Ser Arg Leu Pro Pro Arg
                1925                1930                1935    
His Leu His Val Val His Thr Gly Lys Thr Ser Val Val Ile Lys Trp
            1940                1945                1950        
Glu Ser Pro Tyr Asp Ser Pro Asp Gln Asp Leu Leu Tyr Ala Ile Ala
        1955                1960                1965            
Val Lys Asp Leu Ile Arg Lys Thr Asp Arg Ser Tyr Lys Val Lys Ser
    1970                1975                1980                
Arg Asn Ser Thr Val Glu Tyr Thr Leu Asn Lys Leu Glu Pro Gly Gly
1985                1990                1995                2000
Lys Tyr His Ile Ile Val Gln Leu Gly Asn Met Ser Lys Asp Ser Ser
                2005                2010                2015    
Ile Lys Ile Thr Thr Val Ser Leu Ser Ala Pro Asp Ala Leu Lys Ile
            2020                2025                2030        
Ile Thr Glu Asn Asp His Val Leu Leu Phe Trp Lys Ser Leu Ala Leu
        2035                2040                2045            
Lys Glu Lys His Phe Asn Glu Ser Arg Gly Tyr Glu Ile His Met Phe
    2050                2055                2060                
Asp Ser Ala Met Asn Ile Thr Ala Tyr Leu Gly Asn Thr Thr Asp Asn
2065                2070                2075                2080
Phe Phe Lys Ile Ser Asn Leu Lys Met Gly His Asn Tyr Thr Phe Thr
                2085                2090                2095    
Val Gln Ala Arg Cys Leu Phe Gly Asn Gln Ile Cys Gly Glu Pro Ala
            2100                2105                2110        
Ile Leu Leu Tyr Asp Glu Leu Gly Ser Gly Ala Asp Ala Ser Ala Thr
        2115                2120                2125            
Gln Ala Ala Arg Ser Thr Asp Val Ala Ala Val Val Val Pro Ile Leu
    2130                2135                2140                
Phe Leu Ile Leu Leu Ser Leu Gly Val Gly Phe Ala Ile Leu Tyr Thr
2145                2150                2155                2160
Lys His Arg Arg Leu Gln Ser Ser Phe Thr Ala Phe Ala Asn Ser His
                2165                2170                2175    
Tyr Ser Ser Arg Leu Gly Ser Ala Ile Phe Ser Ser Gly Asp Asp Leu
            2180                2185                2190        
Gly Glu Asp Asp Glu Asp Ala Pro Met Ile Thr Gly Phe Ser Asp Asp
        2195                2200                2205            
Val Pro Met Val Ile Ala
    2210                


<210> 6667
<211> 362
<212> PRT
<213> Homo sapiens

<400> 6667
Met Glu Leu Gly Ser Cys Leu Glu Gly Gly Arg Glu Ala Ala Glu Glu
 1               5                  10                  15      
Glu Gly Glu Pro Glu Val Lys Lys Arg Arg Leu Leu Cys Val Glu Phe
            20                  25                  30          
Ala Ser Val Ala Ser Cys Asp Ala Ala Val Ala Gln Cys Phe Leu Ala
        35                  40                  45              
Glu Asn Asp Trp Glu Met Glu Arg Ala Leu Asn Ser Tyr Phe Glu Pro
    50                  55                  60                  
Pro Val Glu Glu Ser Ala Leu Glu Arg Arg Pro Glu Thr Ile Ser Glu
65                  70                  75                  80  
Pro Lys Thr Tyr Val Asp Leu Thr Asn Glu Glu Thr Thr Asp Ser Thr
                85                  90                  95      
Thr Ser Lys Ile Ser Pro Ser Glu Asp Thr Gln Gln Glu Asn Gly Ser
            100                 105                 110         
Met Phe Ser Leu Ile Thr Trp Asn Ile Asp Gly Leu Asp Leu Asn Asn
        115                 120                 125             
Leu Ser Glu Arg Ala Arg Gly Val Cys Ser Tyr Leu Ala Leu Tyr Ser
    130                 135                 140                 
Pro Asp Val Ile Phe Leu Gln Glu Val Ile Pro Pro Tyr Tyr Ser Tyr
145                 150                 155                 160 
Leu Lys Lys Arg Ser Ser Asn Tyr Glu Ile Ile Thr Gly His Glu Glu
                165                 170                 175     
Gly Tyr Phe Thr Ala Ile Met Leu Lys Lys Ser Arg Val Lys Leu Lys
            180                 185                 190         
Ser Gln Glu Ile Ile Pro Phe Pro Ser Thr Lys Met Met Arg Asn Leu
        195                 200                 205             
Leu Cys Val His Val Asn Val Ser Gly Asn Glu Leu Cys Leu Met Thr
    210                 215                 220                 
Ser His Leu Glu Ser Thr Arg Gly His Ala Ala Glu Arg Met Asn Gln
225                 230                 235                 240 
Leu Lys Met Val Leu Lys Lys Met Gln Glu Ala Pro Glu Ser Ala Thr
                245                 250                 255     
Val Ile Phe Ala Gly Asp Thr Asn Leu Arg Asp Arg Glu Val Thr Arg
            260                 265                 270         
Cys Gly Gly Leu Pro Asn Asn Ile Val Asp Val Trp Glu Phe Leu Gly
        275                 280                 285             
Lys Pro Lys His Cys Gln Tyr Thr Trp Asp Thr Gln Met Asn Ser Asn
    290                 295                 300                 
Leu Gly Ile Thr Ala Ala Cys Lys Leu Arg Phe Asp Arg Ile Phe Phe
305                 310                 315                 320 
Arg Ala Ala Ala Glu Glu Gly His Ile Ile Pro Arg Ser Leu Asp Leu
                325                 330                 335     
Leu Gly Leu Glu Lys Leu Asp Cys Gly Arg Phe Pro Ser Asp His Trp
            340                 345                 350         
Gly Leu Leu Cys Asn Leu Asp Ile Ile Leu
        355                 360         


<210> 6668
<211> 304
<212> PRT
<213> Homo sapiens

<400> 6668
Met Ala Thr Trp Lys Ser Pro Cys Phe Leu Tyr Cys Leu Phe Ile Leu
 1               5                  10                  15      
Gly Pro Arg Leu Thr Gly Gln Asn Asn Ser Val Asp Leu Thr Asn Glu
            20                  25                  30          
Glu Thr Thr Asp Ser Thr Thr Ser Lys Ile Ser Pro Ser Glu Asp Thr
        35                  40                  45              
Gln Gln Glu Asn Gly Ser Met Phe Ser Leu Ile Thr Trp Asn Ile Asp
    50                  55                  60                  
Gly Leu Asp Leu Asn Asn Leu Ser Glu Arg Ala Arg Gly Val Cys Ser
65                  70                  75                  80  
Tyr Leu Ala Leu Tyr Ser Pro Asp Val Ile Phe Leu Gln Glu Val Ile
                85                  90                  95      
Pro Pro Tyr Tyr Ser Tyr Leu Lys Lys Arg Ser Ser Asn Tyr Glu Ile
            100                 105                 110         
Ile Thr Gly His Glu Glu Gly Tyr Phe Thr Ala Ile Met Leu Lys Lys
        115                 120                 125             
Ser Arg Val Lys Leu Lys Ser Gln Glu Ile Ile Pro Phe Pro Ser Thr
    130                 135                 140                 
Lys Met Met Arg Asn Leu Leu Cys Val His Val Asn Val Ser Gly Asn
145                 150                 155                 160 
Glu Leu Cys Leu Met Thr Ser His Leu Glu Ser Thr Arg Gly His Ala
                165                 170                 175     
Ala Glu Arg Met Asn Gln Leu Lys Met Val Leu Lys Lys Met Gln Glu
            180                 185                 190         
Ala Pro Glu Ser Ala Thr Val Ile Phe Ala Gly Asp Thr Asn Leu Arg
        195                 200                 205             
Asp Arg Glu Val Thr Arg Cys Gly Gly Leu Pro Asn Asn Ile Val Asp
    210                 215                 220                 
Val Trp Glu Phe Leu Gly Lys Pro Lys His Cys Gln Tyr Thr Trp Asp
225                 230                 235                 240 
Thr Gln Met Asn Ser Asn Leu Gly Ile Thr Ala Ala Cys Lys Leu Arg
                245                 250                 255     
Phe Asp Arg Ile Phe Phe Arg Ala Ala Ala Glu Glu Gly His Ile Ile
            260                 265                 270         
Pro Arg Ser Leu Asp Leu Leu Gly Leu Glu Lys Leu Asp Cys Gly Arg
        275                 280                 285             
Phe Pro Ser Asp His Trp Gly Leu Leu Cys Asn Leu Asp Ile Ile Leu
    290                 295                 300                 


<210> 6669
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 6669
Met Leu Val Gly Gln Gly Ala Gly Pro Leu Gly Pro Ala Val Val Thr
 1               5                  10                  15      
Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser
            20                  25                  30          
Arg Asp Leu Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu
        35                  40                  45              
Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr
    50                  55                  60                  
Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile
65                  70                  75                  80  
Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu
                85                  90                  95      
Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val
            100                 105                 110         
Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly
        115                 120                 125             
Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro
    130                 135                 140                 
Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile
145                 150                 155                 160 
Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val
                165                 170                 175     
Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu
            180                 185                 190         
Lys Glu Ala Ser Thr Thr Val Ser Val Thr Asn Ser Asn Ala Asn Ala
        195                 200                 205             
Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg
    210                 215                 220                 
Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser
225                 230                 235                 240 
Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro
                245                 250                 255     
Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val
            260                 265                 270         
Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly
        275                 280                 285             
Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val
    290                 295                 300                 
Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile
305                 310                 315                 320 
Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu
                325                 330                 335     
Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn
            340                 345                 350         
Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu
        355                 360                 365             
Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu
    370                 375                 380                 
Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu
385                 390                 395                 400 
Ala Asp Ile Ile Ala Thr Gly Phe Ser Val Cys Gly Gln Ile Ser Ile
                405                 410                 415     
Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val
            420                 425                 430         
Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp
        435                 440                 445             
Ala His Gly Ser Phe Cys Phe Lys Ala Lys Pro Gly Thr Tyr Lys Val
    450                 455                 460                 
Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys
465                 470                 475                 480 
Pro Gln Thr Phe Pro Leu Thr Val Thr Asn Arg Pro Met Met Asp Val
                485                 490                 495     
Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu
            500                 505                 510         
Asn Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln
        515                 520                 525             
Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr
    530                 535                 540                 
Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met
545                 550                 555                 560 
His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu
                565                 570                 575     
Glu Asp Asp Met Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu
            580                 585                 590         
Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly
        595                 600                 605             
Asn Gly Arg Glu Asn Val Gly Ile Tyr Ser Leu Phe Lys Gly Val Asn
    610                 615                 620                 
Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser
625                 630                 635                 640 
Cys His Arg Phe Glu Gln Ala Phe Tyr Ile Tyr Asp Thr Ser Ser Pro
                645                 650                 655     
Ser Ile Phe Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile
            660                 665                 670         
Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile
        675                 680                 685             
Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu
    690                 695                 700                 
Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu
705                 710                 715                 720 
Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro
                725                 730                 735     
Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp
            740                 745                 750         
Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser
        755                 760                 765             
Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser
    770                 775                 780                 
Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly
785                 790                 795                 800 
Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile
                805                 810                 815     
Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr
            820                 825                 830         
Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu
        835                 840                 845             
Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu
    850                 855                 860                 
Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe
865                 870                 875                 880 
Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser
                885                 890                 895     
Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly
            900                 905                 910         
Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro
        915                 920                 925             
Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val
    930                 935                 940                 
Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala
945                 950                 955                 960 
Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln
                965                 970                 975     
Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly
            980                 985                 990         
Glu Asp Thr Val Thr Asp Glu Glu Gly Lys Phe Arg Leu Arg Gly Leu
        995                 1000                1005            
Leu Pro Gly Cys Val Tyr His Val Gln Leu Lys Ala Glu Gly Asn Asp
    1010                1015                1020                
His Ile Glu Arg Ala Leu Pro His His Arg Val Ile Glu Val Gly Asn
1025                1030                1035                1040
Asn Asp Ile Asp Asp Val Asn Ile Ile Val Phe Arg Gln Ile Asn Gln
                1045                1050                1055    
Phe Asp Leu Ser Gly Asn Val Ile Thr Ser Ser Glu Tyr Leu Pro Thr
            1060                1065                1070        
Leu Trp Val Lys Leu Tyr Lys Ser Glu Asn Leu Asp Asn Pro Ile Gln
        1075                1080                1085            
Thr Val Ser Leu Gly Gln Ser Leu Phe Phe His Phe Pro Pro Leu Leu
    1090                1095                1100                
Arg Asp Gly Glu Asn Tyr Val Val Leu Leu Asp Ser Thr Leu Pro Arg
1105                1110                1115                1120
Ser Gln Tyr Asp Tyr Ile Leu Pro Gln Val Ser Phe Thr Ala Val Gly
                1125                1130                1135    
Tyr His Lys His Thr Thr Leu Ile Phe Asn Pro Thr Arg Lys Leu Pro
            1140                1145                1150        
Glu Gln Asp Ile Ala Gln Gly Ser Tyr Ile Ala Leu Pro Leu Thr Leu
        1155                1160                1165            
Leu Val Leu Leu Ala Gly Tyr Asn His Asp Lys Leu Ile Pro Leu Leu
    1170                1175                1180                
Leu Gln Leu Thr Ser Arg Leu Gln Gly Val Arg Ala Leu Gly Gln Ala
1185                1190                1195                1200
Ala Ser Asp Asn Ser Gly Pro Glu Asp Ala Lys Arg Gln Ala Lys Lys
                1205                1210                1215    
Gln Lys Thr Arg Arg Thr
            1220        


<210> 6670
<211> 1692
<212> PRT
<213> Homo sapiens

<400> 6670
Ile Pro Glu Gly Arg Leu Ser Ala Glu His Thr Ser Ser Leu Val Pro
 1               5                  10                  15      
Ser Leu His Ile Thr Thr Leu Gly Gln Glu Gln Ala Ile Leu Ser Gly
            20                  25                  30          
Ala Val Pro Ala Ser Pro Ser Thr Gly Thr Ala Asp Phe Pro Ser Ile
        35                  40                  45              
Leu Thr Phe Leu Gln Pro Thr Glu Asn His Ala Ser Pro Ser Pro Val
    50                  55                  60                  
Pro Glu Met Pro Thr Leu Pro Ala Glu Gly Ser Asp Gly Ser Pro Pro
65                  70                  75                  80  
Ala Thr Arg Asp Leu Leu Leu Ser Ser Lys Val Pro Asn Leu Leu Ser
                85                  90                  95      
Thr Ser Trp Thr Phe Pro Arg Trp Lys Lys Asp Ser Val Thr Ala Ile
            100                 105                 110         
Leu Gly Lys Asn Glu Glu Ala Asn Val Thr Ile Pro Leu Gln Gly Phe
        115                 120                 125             
Pro Arg Lys Glu Val Leu Ser Leu His Thr Val Asn Gly Phe Val Ser
    130                 135                 140                 
Asp Phe Ser Thr Gly Ser Val Ser Ser Pro Ile Ile Thr Ala Pro Arg
145                 150                 155                 160 
Thr Asn Pro Leu Ser Ser Gly Pro Pro Leu Pro Ser Ile Leu Ser Ile
                165                 170                 175     
Gln Ala Thr Gln Thr Val Phe Pro Ser Leu Leu Ala Phe Ser Ser Thr
            180                 185                 190         
Lys Pro Glu Val Tyr Ala Ala Ala Val Asp His Ser Gly Leu Pro Ala
        195                 200                 205             
Ser Ala Pro Lys Gln Val Arg Ala Ser Pro Ser Ser Met Asp Val Tyr
    210                 215                 220                 
Asp Ser Leu Thr Ile Gly Asp Met Lys Lys Pro Ala Thr Thr Asp Val
225                 230                 235                 240 
Phe Trp Ser Ser Leu Ser Ala Glu Thr Gly Ser Leu Ser Thr Glu Ser
                245                 250                 255     
Ile Ile Ser Gly Leu Gln Gln Gln Thr Asn Tyr Asp Leu Asn Gly His
            260                 265                 270         
Thr Ile Ser Thr Thr Ser Trp Glu Thr His Leu Ala Pro Thr Ala Pro
        275                 280                 285             
Pro Asn Gly Leu Thr Ser Ala Ala Asp Ala Ile Lys Ser Gln Asp Phe
    290                 295                 300                 
Lys Asp Thr Ala Gly His Ser Val Thr Ala Glu Gly Phe Ser Ile Gln
305                 310                 315                 320 
Asp Leu Val Leu Gly Thr Ser Ile Glu Gln Pro Val Gln Gln Ser Asp
                325                 330                 335     
Met Thr Met Val Gly Ser His Ile Asp Leu Trp Pro Thr Ser Asn Asn
            340                 345                 350         
Asn His Ser Arg Asp Phe Gln Thr Ala Glu Val Ala Tyr Tyr Ser Pro
        355                 360                 365             
Thr Thr Arg His Ser Val Ser His Pro Gln Leu Gln Leu Pro Asn Gln
    370                 375                 380                 
Pro Ala His Pro Leu Leu Leu Thr Ser Pro Gly Pro Thr Ser Thr Gly
385                 390                 395                 400 
Ser Leu Gln Glu Met Leu Ser Asp Gly Thr Asp Thr Gly Ser Glu Ile
                405                 410                 415     
Ser Ser Asp Ile Asn Ser Ser Pro Glu Arg Asn Ala Ser Thr Pro Phe
            420                 425                 430         
Gln Asn Ile Leu Gly Tyr His Ser Ala Ala Glu Ser Ser Ile Ser Thr
        435                 440                 445             
Ser Val Phe Pro Arg Thr Ser Ser Arg Val Leu Arg Ala Ser Gln His
    450                 455                 460                 
Pro Lys Lys Trp Thr Ala Asp Thr Val Ser Ser Lys Val Gln Pro Thr
465                 470                 475                 480 
Ala Ala Ala Ala Val Thr Leu Phe Leu Arg Lys Ser Ser Pro Pro Ala
                485                 490                 495     
Leu Ser Ala Ala Leu Val Ala Lys Gly Thr Ser Ser Ser Pro Leu Ala
            500                 505                 510         
Val Ala Ser Gly Pro Ala Lys Ser Ser Ser Met Thr Thr Leu Ala Lys
        515                 520                 525             
Asn Val Thr Asn Lys Ala Ala Ser Gly Pro Lys Arg Thr Pro Gly Ala
    530                 535                 540                 
Val His Thr Ala Phe Pro Phe Thr Pro Thr Tyr Met Tyr Ala Arg Thr
545                 550                 555                 560 
Gly His Thr Thr Ser Thr His Thr Ala Ile Ala Arg Lys His Gly His
                565                 570                 575     
Cys Leu Trp Pro Val Val Tyr Asn Leu Pro Pro Pro Gly Lys Pro Gln
            580                 585                 590         
Ala Met His Thr Gly Leu Pro Asn Pro Thr Asn Leu Glu Met Pro Arg
        595                 600                 605             
Ala Ser Thr Pro Arg Pro Leu Thr Val Thr Ala Ala Leu Thr Ser Ile
    610                 615                 620                 
Thr Ala Ser Val Lys Ala Thr Arg Leu Pro Pro Leu Arg Ala Glu Asn
625                 630                 635                 640 
Thr Asp Ala Val Leu Pro Ala Ala Ser Ala Ala Val Val Thr Thr Gly
                645                 650                 655     
Lys Met Ala Ser Asn Leu Glu Cys Gln Met Ser Ser Lys Leu Leu Val
            660                 665                 670         
Lys Thr Val Leu Phe Leu Thr Gln Arg Arg Val Gln Ile Ser Glu Ser
        675                 680                 685             
Leu Lys Phe Ser Ile Ala Lys Gly Leu Thr Gln Ala Leu Arg Lys Ala
    690                 695                 700                 
Phe His Gln Asn Asp Val Ser Ala His Val Asp Ile Leu Glu Tyr Ser
705                 710                 715                 720 
His Asn Val Thr Val Gly Tyr Tyr Ala Thr Lys Gly Lys Leu Val Tyr
                725                 730                 735     
Leu Pro Ala Val Val Ile Glu Met Leu Gly Val Tyr Gly Val Ser Asn
            740                 745                 750         
Val Thr Ala Asp Leu Lys Gln His Thr Pro His Leu Gln Ser Val Ala
        755                 760                 765             
Val Leu Ala Ser Pro Trp Asn Pro Gln Pro Ala Gly Tyr Phe Gln Leu
    770                 775                 780                 
Lys Thr Val Leu Gln Phe Val Ser Gln Ala Asp Asn Ile Gln Ser Cys
785                 790                 795                 800 
Lys Phe Ala Gln Thr Met Glu Gln Arg Leu Gln Lys Ala Phe Gln Asp
                805                 810                 815     
Ala Glu Arg Lys Val Leu Asn Thr Lys Ser Asn Leu Thr Ile Gln Ile
            820                 825                 830         
Val Ser Thr Ser Asn Ala Ser Gln Ala Val Thr Leu Val Tyr Val Val
        835                 840                 845             
Gly Asn Gln Ser Thr Phe Leu Asn Gly Thr Val Ala Ser Ser Leu Leu
    850                 855                 860                 
Ser Gln Leu Ser Ala Glu Leu Val Gly Phe Tyr Leu Thr Tyr Pro Pro
865                 870                 875                 880 
Leu Thr Ile Ala Glu Pro Leu Glu Tyr Pro Asn Leu Asp Ile Ser Glu
                885                 890                 895     
Thr Thr Arg Asp Tyr Trp Val Ile Thr Val Leu Gln Gly Val Asp Asn
            900                 905                 910         
Ser Leu Val Gly Leu His Asn Gln Ser Phe Ala Arg Val Met Glu Gln
        915                 920                 925             
Arg Leu Ala Gln Leu Phe Met Met Ser Gln Gln Gln Gly Arg Arg Phe
    930                 935                 940                 
Lys Arg Ala Thr Thr Leu Gly Ser Tyr Thr Val Gln Met Val Lys Met
945                 950                 955                 960 
Gln Arg Val Pro Gly Pro Lys Asp Pro Ala Glu Leu Thr Tyr Tyr Thr
                965                 970                 975     
Leu Tyr Asn Gly Lys Pro Leu Leu Gly Thr Val Ala Ala Lys Ile Leu
            980                 985                 990         
Ser Thr Ile Asp Ser Gln Arg Met Ala Leu Thr Leu His His Val Val
        995                 1000                1005            
Leu Leu Gln Ala Asp Pro Val Val Lys Asn Pro Pro Asn Asn Leu Trp
    1010                1015                1020                
Ile Ile Ala Ala Val Leu Ala Pro Ile Ala Val Val Thr Val Ile Ile
1025                1030                1035                1040
Ile Ile Ile Thr Ala Val Leu Cys Arg Lys Asn Lys Asn Asp Phe Lys
                1045                1050                1055    
Pro Asp Thr Met Ile Asn Leu Pro Gln Arg Ala Lys Pro Val Gln Gly
            1060                1065                1070        
Phe Asp Tyr Ala Lys Gln His Leu Gly Gln Gln Gly Ala Asp Glu Glu
        1075                1080                1085            
Val Ile Pro Val Thr Gln Glu Thr Val Val Leu Pro Leu Pro Ile Arg
    1090                1095                1100                
Asp Ala Pro Gln Glu Arg Asp Val Ala Gln Asp Gly Ser Thr Ile Lys
1105                1110                1115                1120
Thr Ala Lys Ser Thr Glu Thr Arg Lys Ser Arg Ser Pro Ser Glu Asn
                1125                1130                1135    
Gly Ser Val Ile Ser Asn Glu Ser Gly Lys Pro Ser Ser Gly Arg Arg
            1140                1145                1150        
Ser Pro Gln Asn Val Met Ala Gln Gln Lys Val Thr Lys Glu Glu Ala
        1155                1160                1165            
Arg Lys Arg Asn Val Pro Ala Ser Asp Glu Glu Glu Gly Ala Val Leu
    1170                1175                1180                
Phe Asp Asn Ser Ser Lys Val Ala Ala Glu Pro Phe Asp Thr Ser Ser
1185                1190                1195                1200
Gly Ser Val Gln Leu Ile Ala Ile Lys Pro Thr Ala Leu Pro Met Val
                1205                1210                1215    
Pro Pro Thr Ser Asp Arg Ser Gln Glu Ser Ser Ala Val Leu Asn Gly
            1220                1225                1230        
Glu Val Asn Lys Ala Leu Lys Gln Lys Ser Asp Ile Glu His Tyr Arg
        1235                1240                1245            
Asn Lys Leu Arg Leu Lys Ala Lys Arg Lys Gly Tyr Tyr Asp Phe Pro
    1250                1255                1260                
Ala Val Glu Thr Ser Lys Gly Leu Thr Glu Arg Lys Lys Met Tyr Glu
1265                1270                1275                1280
Lys Ala Pro Lys Glu Met Glu His Val Leu Asp Pro Asp Ser Glu Leu
                1285                1290                1295    
Cys Ala Pro Phe Thr Glu Ser Lys Asn Arg Gln Gln Met Lys Asn Ser
            1300                1305                1310        
Val Tyr Arg Ser Arg Gln Ser Leu Asn Ser Pro Ser Pro Gly Glu Thr
        1315                1320                1325            
Glu Met Asp Leu Leu Val Thr Arg Glu Arg Pro Arg Arg Gly Ile Arg
    1330                1335                1340                
Asn Ser Gly Tyr Asp Thr Glu Pro Glu Ile Ile Glu Glu Thr Asn Ile
1345                1350                1355                1360
Asp Arg Val Pro Glu Pro Arg Gly Tyr Ser Arg Ser Arg Gln Val Lys
                1365                1370                1375    
Gly His Ser Glu Thr Ser Thr Leu Ser Ser Gln Pro Ser Ile Asp Glu
            1380                1385                1390        
Val Arg Gln Gln Met His Met Leu Leu Glu Glu Ala Phe Ser Leu Ala
        1395                1400                1405            
Ser Ala Gly His Ala Gly Gln Ser Arg His Gln Glu Ala Tyr Gly Ser
    1410                1415                1420                
Ala Gln His Leu Pro Tyr Ser Glu Val Val Thr Ser Ala Pro Gly Thr
1425                1430                1435                1440
Met Thr Arg Pro Arg Ala Gly Val Gln Trp Val Pro Thr Tyr Arg Pro
                1445                1450                1455    
Glu Met Tyr Gln Tyr Ser Leu Pro Arg Pro Ala Tyr Arg Phe Ser Gln
            1460                1465                1470        
Leu Pro Glu Met Val Met Gly Ser Pro Pro Pro Pro Val Pro Pro Arg
        1475                1480                1485            
Thr Gly Pro Val Ala Val Ala Ser Leu Arg Arg Ser Thr Ser Asp Ile
    1490                1495                1500                
Gly Ser Lys Thr Arg Met Ala Glu Ser Thr Gly Pro Glu Pro Ala Gln
1505                1510                1515                1520
Leu His Asp Ser Ala Ser Phe Thr Gln Met Ser Arg Gly Pro Val Ser
                1525                1530                1535    
Val Thr Gln Leu Asp Gln Ser Ala Leu Asn Tyr Ser Gly Asn Thr Val
            1540                1545                1550        
Pro Ala Val Phe Ala Ile Pro Ala Ala Asn Arg Pro Gly Phe Thr Gly
        1555                1560                1565            
Tyr Phe Ile Pro Thr Pro Pro Ser Ser Tyr Arg Asn Gln Ala Trp Met
    1570                1575                1580                
Ser Tyr Ala Gly Glu Asn Glu Leu Pro Ser Gln Trp Ala Asp Ser Val
1585                1590                1595                1600
Pro Leu Pro Gly Tyr Ile Glu Ala Tyr Pro Arg Ser Arg Tyr Pro Gln
                1605                1610                1615    
Ser Ser Pro Ser Arg Leu Pro Arg Gln Tyr Ser Gln Pro Ala Asn Leu
            1620                1625                1630        
His Pro Ser Leu Glu Gln Ala Pro Ala Pro Ser Thr Ala Ala Ser Gln
        1635                1640                1645            
Gln Ser Leu Ala Glu Asn Asp Pro Ser Asp Ala Pro Leu Thr Asn Ile
    1650                1655                1660                
Ser Thr Ala Ala Leu Val Lys Ala Ile Arg Glu Glu Val Ala Lys Leu
1665                1670                1675                1680
Ala Lys Lys Gln Thr Asp Met Phe Glu Phe Gln Val
                1685                1690        


<210> 6671
<211> 260
<212> PRT
<213> Homo sapiens

<400> 6671
Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg
 1               5                  10                  15      
Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile
            20                  25                  30          
Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg
        35                  40                  45              
Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr
    50                  55                  60                  
Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly
65                  70                  75                  80  
Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile
                85                  90                  95      
Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln
            100                 105                 110         
Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val
        115                 120                 125             
Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe
    130                 135                 140                 
Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr
145                 150                 155                 160 
Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe
                165                 170                 175     
His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr
            180                 185                 190         
Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His
        195                 200                 205             
Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val
    210                 215                 220                 
Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly
225                 230                 235                 240 
Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala
                245                 250                 255     
Gln Gly Thr Leu
            260 


<210> 6672
<211> 1186
<212> PRT
<213> Homo sapiens

<400> 6672
Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser Ala Glu Arg Thr
 1               5                  10                  15      
Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser Ser Asn Gly His
            20                  25                  30          
Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys Lys Lys Lys Pro
        35                  40                  45              
Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu Leu Arg His Gly
    50                  55                  60                  
Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp Pro Val Asp Val
65                  70                  75                  80  
Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp Val Cys His Arg
                85                  90                  95      
Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg Val Tyr His Ala
            100                 105                 110         
Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro
        115                 120                 125             
Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu Thr Gln Ser Lys
    130                 135                 140                 
Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe
145                 150                 155                 160 
Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro
                165                 170                 175     
Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro
            180                 185                 190         
Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly
        195                 200                 205             
Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys
    210                 215                 220                 
Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val
225                 230                 235                 240 
Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile Glu Val Cys Pro
                245                 250                 255     
Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu
            260                 265                 270         
Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe
        275                 280                 285             
Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp
    290                 295                 300                 
Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn
305                 310                 315                 320 
Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys
                325                 330                 335     
Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn
            340                 345                 350         
Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro
        355                 360                 365             
Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro
    370                 375                 380                 
Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn
385                 390                 395                 400 
Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu
                405                 410                 415     
Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser
            420                 425                 430         
Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser Asp Val Glu Gln
        435                 440                 445             
Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu
    450                 455                 460                 
Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys
465                 470                 475                 480 
Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro
                485                 490                 495     
Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr
            500                 505                 510         
Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp
        515                 520                 525             
Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro
    530                 535                 540                 
Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu
545                 550                 555                 560 
Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile
                565                 570                 575     
Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser
            580                 585                 590         
Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln
        595                 600                 605             
Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln
    610                 615                 620                 
Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn
625                 630                 635                 640 
Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu
                645                 650                 655     
Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu
            660                 665                 670         
Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp
        675                 680                 685             
Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly
    690                 695                 700                 
Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp
705                 710                 715                 720 
His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro
                725                 730                 735     
Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro Ser Thr Thr Val
            740                 745                 750         
Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr Arg Ser Ser Ala
        755                 760                 765             
Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr
    770                 775                 780                 
Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly Ser Pro Val Lys
785                 790                 795                 800 
Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro Ala Val Gln Arg
                805                 810                 815     
Val Val Trp Asn Ser Ser Ser Lys Phe Gln Thr Ser Ser Gln Lys Trp
            820                 825                 830         
His Met Gln Lys Met Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln Asn
        835                 840                 845             
Gln Gln Gln Gln Pro Gln Ser Ser Gln Gly Thr Arg Tyr Gln Thr Arg
    850                 855                 860                 
Gln Ala Val Lys Ala Val Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser
865                 870                 875                 880 
Thr Ser Thr Ile Thr Leu Val Thr Ser Thr Gln Ser Ser Pro Leu Val
                885                 890                 895     
Thr Ser Ser Gly Ser Met Ser Thr Leu Val Ser Ser Val Asn Ala Asp
            900                 905                 910         
Leu Pro Ile Ala Thr Ala Ser Ala Asp Val Ala Ala Asp Ile Ala Lys
        915                 920                 925             
Tyr Thr Ser Lys Met Met Asp Ala Ile Lys Gly Thr Met Thr Glu Ile
    930                 935                 940                 
Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile
945                 950                 955                 960 
Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu Gln Trp Leu His Gln Gln
                965                 970                 975     
Glu Leu Ser Glu Met Lys His Asn Leu Glu Leu Thr Met Ala Glu Met
            980                 985                 990         
Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg Leu Ile Ala Glu Val Lys
        995                 1000                1005            
Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala Val Asp Glu Thr Lys Lys
    1010                1015                1020                
Lys Gln Trp Cys Ala Asn Cys Lys Lys Glu Ala Ile Phe Tyr Cys Cys
1025                1030                1035                1040
Trp Asn Thr Ser Tyr Cys Asp Tyr Pro Cys Gln Gln Ala His Trp Pro
                1045                1050                1055    
Glu His Met Lys Ser Cys Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu
            1060                1065                1070        
Ala Asp Ala Glu Val Asn Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly
        1075                1080                1085            
Ser Ser Ser Ser Thr Gln Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser
    1090                1095                1100                
Lys Glu Lys Glu Thr Ser Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr
1105                1110                1115                1120
Leu Asp Leu Ser Gly Ser Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly
                1125                1130                1135    
Ser Asn Gln Gly Ser Asp His Ser Arg Ser Asn Lys Ser Ser Trp Ser
            1140                1145                1150        
Ser Ser Asp Glu Lys Arg Gly Ser Thr Arg Ser Asp His Asn Thr Ser
        1155                1160                1165            
Thr Ser Thr Lys Ser Leu Leu Pro Lys Glu Ser Arg Leu Asp Thr Phe
    1170                1175                1180                
Trp Asp
1185    


<210> 6673
<211> 1188
<212> PRT
<213> Homo sapiens

<400> 6673
Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu
 1               5                  10                  15      
Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser
            20                  25                  30          
Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser
        35                  40                  45              
Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys
    50                  55                  60                  
Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu
65                  70                  75                  80  
Leu Arg His Gly Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp
                85                  90                  95      
Pro Val Asp Val Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp
            100                 105                 110         
Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg
        115                 120                 125             
Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp
    130                 135                 140                 
Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu
145                 150                 155                 160 
Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr
                165                 170                 175     
Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala
            180                 185                 190         
Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr
        195                 200                 205             
Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys
    210                 215                 220                 
Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile
225                 230                 235                 240 
Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln
                245                 250                 255     
Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile
            260                 265                 270         
Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn
        275                 280                 285             
Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys
    290                 295                 300                 
Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp
305                 310                 315                 320 
Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val
                325                 330                 335     
Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val
            340                 345                 350         
Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val
        355                 360                 365             
Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro
    370                 375                 380                 
Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp
385                 390                 395                 400 
Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys
                405                 410                 415     
Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser
            420                 425                 430         
Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp
        435                 440                 445             
Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser
    450                 455                 460                 
Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser
465                 470                 475                 480 
Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro
                485                 490                 495     
Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys
            500                 505                 510         
Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys
        515                 520                 525             
Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys
    530                 535                 540                 
Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser
545                 550                 555                 560 
Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe
                565                 570                 575     
Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly
            580                 585                 590         
Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp
        595                 600                 605             
Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser
    610                 615                 620                 
Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys
625                 630                 635                 640 
Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro
                645                 650                 655     
Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser
            660                 665                 670         
Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser
        675                 680                 685             
Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His
    690                 695                 700                 
Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr
705                 710                 715                 720 
Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp
                725                 730                 735     
Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu
            740                 745                 750         
Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro
        755                 760                 765             
Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr
    770                 775                 780                 
Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser
785                 790                 795                 800 
Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly
                805                 810                 815     
Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro
            820                 825                 830         
Ala Val Gln Arg Val Val Trp Asn Ser Ser Thr Val Gln Gln Lys Glu
        835                 840                 845             
Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr
    850                 855                 860                 
Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val
865                 870                 875                 880 
Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val
                885                 890                 895     
Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys
            900                 905                 910         
Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly
        915                 920                 925             
Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu
    930                 935                 940                 
Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu
945                 950                 955                 960 
Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg
                965                 970                 975     
Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala
            980                 985                 990         
Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn Cys Lys Lys Glu
        995                 1000                1005            
Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys Asp Tyr Pro Cys
    1010                1015                1020                
Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys Thr Gln Ser Ala
1025                1030                1035                1040
Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn Thr Glu Thr Leu
                1045                1050                1055    
Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln Ser Ala Pro Ser
            1060                1065                1070        
Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser Ala Glu Lys Ser
        1075                1080                1085            
Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser Arg Glu Thr Pro
    1090                1095                1100                
Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Val Ser Lys Arg Cys
1105                1110                1115                1120
Asp Lys Gln Pro Ala Tyr Ala Pro Thr Thr Thr Asp His Gln Pro His
                1125                1130                1135    
Pro Asn Tyr Pro Ala Gln Lys Tyr His Ser Arg Ser Asn Lys Ser Ser
            1140                1145                1150        
Trp Ser Ser Ser Asp Glu Lys Arg Gly Ser Thr Arg Ser Asp His Asn
        1155                1160                1165            
Thr Ser Thr Ser Thr Lys Ser Leu Leu Pro Lys Glu Ser Arg Leu Asp
    1170                1175                1180                
Thr Phe Trp Asp
1185            


<210> 6674
<211> 1180
<212> PRT
<213> Homo sapiens

<400> 6674
Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu
 1               5                  10                  15      
Val Val Glu Gly Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser Ala
            20                  25                  30          
Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser Ser
        35                  40                  45              
Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys Lys
    50                  55                  60                  
Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Asp Gly Arg
65                  70                  75                  80  
Asn Asp Phe Tyr Cys Trp Val Cys His Arg Glu Gly Gln Val Leu Cys
                85                  90                  95      
Cys Glu Leu Cys Pro Arg Val Tyr His Ala Lys Cys Leu Arg Leu Thr
            100                 105                 110         
Ser Glu Pro Glu Gly Asp Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr
        115                 120                 125             
Val Ala Glu Cys Ile Glu Thr Gln Ser Lys Ala Met Thr Met Leu Thr
    130                 135                 140                 
Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe Ala Ile Gln Lys Met Lys
145                 150                 155                 160 
Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro Val Pro Leu Glu Gln His
                165                 170                 175     
Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro Met Asp Leu Cys Thr Leu
            180                 185                 190         
Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu
        195                 200                 205             
Ala Asp Ala Lys Trp Ile Leu His Asn Cys Ile Ile Tyr Asn Gly Gly
    210                 215                 220                 
Asn His Lys Leu Thr Gln Ile Ala Lys Val Val Ile Lys Ile Cys Glu
225                 230                 235                 240 
His Glu Met Asn Glu Ile Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala
                245                 250                 255     
Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu Pro Cys Ser Asn Pro His
            260                 265                 270         
Pro Leu Val Trp Ala Lys Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys
        275                 280                 285             
Ala Leu Arg Asp Lys Asp Gly Gln Val Asp Ala Arg Phe Phe Gly Gln
    290                 295                 300                 
His Asp Arg Ala Trp Val Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys
305                 310                 315                 320 
Glu Ile Pro Phe Ser Val Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala
                325                 330                 335     
Met Gln Glu Met Glu Val Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly
            340                 345                 350         
Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln
        355                 360                 365             
Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys
    370                 375                 380                 
Ile Asp Lys Gln Glu Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser
385                 390                 395                 400 
Pro Lys Ile Leu Met Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg
                405                 410                 415     
Arg Ile Ser Leu Ser Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser
            420                 425                 430         
Ser Val His Thr Gly Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala
        435                 440                 445             
Thr Ser Ser His Phe Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp
    450                 455                 460                 
Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser
465                 470                 475                 480 
Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile
                485                 490                 495     
Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu
            500                 505                 510         
Asn Leu Asp Arg Ser Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu
        515                 520                 525             
Ser Val Gln Gln Gln Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg
    530                 535                 540                 
Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser
545                 550                 555                 560 
Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr
                565                 570                 575     
Ala Val Glu His Ser Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser
            580                 585                 590         
Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro
        595                 600                 605             
Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser
    610                 615                 620                 
Ala Val Lys Lys Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu
625                 630                 635                 640 
Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala
                645                 650                 655     
Val Lys Asp Lys Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys
            660                 665                 670         
Ala Lys Pro Ser Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp
        675                 680                 685             
Glu Thr Asp Ser Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu
    690                 695                 700                 
Ser Glu Leu Val Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly
705                 710                 715                 720 
Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val
                725                 730                 735     
Val Gly Lys Thr Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro
            740                 745                 750         
Glu Thr Pro Val Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly
        755                 760                 765             
Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro
    770                 775                 780                 
Ala Pro Ala Ala Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu
785                 790                 795                 800 
Pro Lys Glu Thr Ala Pro Ala Val Gln Arg Val Val Trp Asn Ser Ser
                805                 810                 815     
Ser Lys Phe Gln Thr Ser Ser Gln Lys Trp His Met Gln Lys Met Gln
            820                 825                 830         
Arg Gln Gln Gln Gln Gln Gln Gln Gln Asn Gln Gln Gln Gln Pro Gln
        835                 840                 845             
Ser Ser Gln Gly Thr Arg Tyr Gln Thr Arg Gln Ala Val Lys Ala Val
    850                 855                 860                 
Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu
865                 870                 875                 880 
Val Thr Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met
                885                 890                 895     
Ser Thr Leu Val Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala
            900                 905                 910         
Ser Ala Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met
        915                 920                 925             
Asp Ala Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys
    930                 935                 940                 
Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu
945                 950                 955                 960 
Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys
                965                 970                 975     
His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln
            980                 985                 990         
Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu
        995                 1000                1005            
Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn
    1010                1015                1020                
Cys Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys
1025                1030                1035                1040
Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys
                1045                1050                1055    
Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn
            1060                1065                1070        
Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln
        1075                1080                1085            
Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser
    1090                1095                1100                
Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser
1105                1110                1115                1120
Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp
                1125                1130                1135    
His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg
            1140                1145                1150        
Gly Ser Thr Arg Ser Asp His Asn Thr Ser Thr Ser Thr Lys Ser Leu
        1155                1160                1165            
Leu Pro Lys Glu Ser Arg Leu Asp Thr Phe Trp Asp
    1170                1175                1180


<210> 6675
<211> 995
<212> PRT
<213> Homo sapiens

<400> 6675
Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr Leu Leu Lys Phe Ala
 1               5                  10                  15      
Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala Phe Gln Lys Pro Val
            20                  25                  30          
Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr Ile Phe His Pro Met
        35                  40                  45              
Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys Lys Met Tyr Gly Cys
    50                  55                  60                  
Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile Leu His Asn Cys Ile
65                  70                  75                  80  
Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln Ile Ala Lys Val Val
                85                  90                  95      
Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile Glu Val Cys Pro Glu
            100                 105                 110         
Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn Trp Phe Cys Glu Pro
        115                 120                 125             
Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys Leu Lys Gly Phe Pro
    130                 135                 140                 
Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp Gly Gln Val Asp Ala
145                 150                 155                 160 
Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val Pro Ile Asn Asn Cys
                165                 170                 175     
Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val Lys Lys Thr Lys Ser
            180                 185                 190         
Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val Tyr Val Glu Asn Ile
        195                 200                 205             
Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro Phe Arg Thr Pro Tyr
    210                 215                 220                 
Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp Pro Thr Asn Pro Ser
225                 230                 235                 240 
Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys Val Lys Leu Asn Phe
                245                 250                 255     
Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser Lys Pro Val Leu Ser
            260                 265                 270         
Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp Met Pro Arg Ser Pro
        275                 280                 285             
Met Ser Thr Asn Ser Ser Val His Thr Gly Ser Asp Val Glu Gln Asp
    290                 295                 300                 
Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser Ala Ser Glu Glu Ser
305                 310                 315                 320 
Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro Ala Ser Thr Lys Thr
                325                 330                 335     
Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys Pro Phe Ser Pro Gln
            340                 345                 350         
Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys Thr Ser Thr Thr Gly
        355                 360                 365             
Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys Ala Glu Met Asp Leu
    370                 375                 380                 
Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser Thr Pro Val Pro Leu
385                 390                 395                 400 
Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe Gln Leu Asn Leu Asp
                405                 410                 415     
Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly Ile Asn Glu Ile Ser
            420                 425                 430         
Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp Ser Glu Asp Ser Glu
        435                 440                 445             
Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser Asp Asp Glu Gln Lys
    450                 455                 460                 
Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys Glu Gly Cys Gln Met
465                 470                 475                 480 
Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro Lys Pro Thr Asn Pro
                485                 490                 495     
Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser Pro Ala Ser Glu Lys
            500                 505                 510         
Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser Pro Glu Pro Glu Lys
        515                 520                 525             
Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His Pro Ile Lys Asp Lys
    530                 535                 540                 
Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr Val His Leu Gly Leu
545                 550                 555                 560 
Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp Leu Gly Glu Asp His
                565                 570                 575     
Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu Pro Lys Glu Pro Ser
            580                 585                 590         
Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro Ser Thr Thr Val Gly
        595                 600                 605             
Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr Arg Ser Ser Ala Gln
    610                 615                 620                 
Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser Thr Ser Ser Thr Val
625                 630                 635                 640 
Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly Ser Pro Val Lys Lys
                645                 650                 655     
Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro Ala Val Gln Arg Val
            660                 665                 670         
Val Trp Asn Ser Ser Thr Val Gln Gln Lys Glu Ile Thr Gln Ser Pro
        675                 680                 685             
Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr Gln Ser Ser Pro Leu
    690                 695                 700                 
Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val Ser Ser Val Asn Ala
705                 710                 715                 720 
Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val Ala Ala Asp Ile Ala
                725                 730                 735     
Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys Gly Thr Met Thr Glu
            740                 745                 750         
Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly Ser Thr Ile Ala Glu
        755                 760                 765             
Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu Gln Trp Leu His Gln
    770                 775                 780                 
Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu Leu Thr Met Ala Glu
785                 790                 795                 800 
Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg Leu Ile Ala Glu Val
                805                 810                 815     
Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala Val Asp Glu Thr Lys
            820                 825                 830         
Lys Lys Gln Trp Cys Ala Asn Cys Lys Lys Glu Ala Ile Phe Tyr Cys
        835                 840                 845             
Cys Trp Asn Thr Ser Tyr Cys Asp Tyr Pro Cys Gln Gln Ala His Trp
    850                 855                 860                 
Pro Glu His Met Lys Ser Cys Thr Gln Ser Ala Thr Ala Pro Gln Gln
865                 870                 875                 880 
Glu Ala Asp Ala Glu Val Asn Thr Glu Thr Leu Asn Lys Ser Ser Gln
                885                 890                 895     
Gly Ser Ser Ser Ser Thr Gln Ser Ala Pro Ser Glu Thr Ala Ser Ala
            900                 905                 910         
Ser Lys Glu Lys Glu Thr Ser Ala Glu Lys Ser Lys Glu Ser Gly Ser
        915                 920                 925             
Thr Leu Asp Leu Ser Gly Ser Arg Glu Thr Pro Ser Ser Ile Leu Leu
    930                 935                 940                 
Gly Ser Asn Gln Gly Ser Asp His Ser Arg Ser Asn Lys Ser Ser Trp
945                 950                 955                 960 
Ser Ser Ser Asp Glu Lys Arg Gly Ser Thr Arg Ser Asp His Asn Thr
                965                 970                 975     
Ser Thr Ser Thr Lys Ser Leu Leu Pro Lys Glu Ser Arg Leu Asp Thr
            980                 985                 990         
Phe Trp Asp
        995 


<210> 6676
<211> 764
<212> PRT
<213> Homo sapiens

<400> 6676
Met Leu Leu Asp Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp
 1               5                  10                  15      
Lys Gln Glu Lys Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys
            20                  25                  30          
Ile Leu Met Ser Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile
        35                  40                  45              
Ser Leu Ser Asp Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val
    50                  55                  60                  
His Thr Gly Ser Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser
65                  70                  75                  80  
Ser His Phe Ser Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser
                85                  90                  95      
Thr Ala Ser Pro Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser
            100                 105                 110         
Gly Ser Pro Lys Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr
        115                 120                 125             
Lys Thr Asp Lys Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu
    130                 135                 140                 
Asp Arg Ser Lys Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val
145                 150                 155                 160 
Gln Gln Gln Ser Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile
                165                 170                 175     
Arg Ser Arg Phe Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys
            180                 185                 190         
Ala Gln Leu Gly Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val
        195                 200                 205             
Glu His Ser Asp Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser
    210                 215                 220                 
Glu Tyr Ile Ser Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp
225                 230                 235                 240 
Thr Glu Asp Lys Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val
                245                 250                 255     
Lys Lys Lys Pro Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu
            260                 265                 270         
Lys Ser Thr Ser Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys
        275                 280                 285             
Asp Lys Ala Ser Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys
    290                 295                 300                 
Pro Ser Pro His Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr
305                 310                 315                 320 
Asp Ser Pro Thr Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu
                325                 330                 335     
Leu Val Ile Asp Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys
            340                 345                 350         
Asn Lys Lys Glu Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly
        355                 360                 365             
Lys Thr Pro Pro Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr
    370                 375                 380                 
Pro Val Leu Thr Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr
385                 390                 395                 400 
Ala Thr Thr Ser Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro
                405                 410                 415     
Ala Ala Thr Gly Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys
            420                 425                 430         
Glu Thr Ala Pro Ala Val Gln Arg Val Val Trp Asn Ser Ser Thr Val
        435                 440                 445             
Gln Gln Lys Glu Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu
    450                 455                 460                 
Val Thr Ser Thr Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met
465                 470                 475                 480 
Ser Thr Leu Val Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala
                485                 490                 495     
Ser Ala Asp Val Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met
            500                 505                 510         
Asp Ala Ile Lys Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys
        515                 520                 525             
Asn Thr Thr Gly Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu
    530                 535                 540                 
Ile Glu Lys Leu Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys
545                 550                 555                 560 
His Asn Leu Glu Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln
                565                 570                 575     
Glu Arg Asp Arg Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu
            580                 585                 590         
Lys Gln Gln Ala Val Asp Glu Thr Lys Lys Lys Gln Trp Cys Ala Asn
        595                 600                 605             
Cys Lys Lys Glu Ala Ile Phe Tyr Cys Cys Trp Asn Thr Ser Tyr Cys
    610                 615                 620                 
Asp Tyr Pro Cys Gln Gln Ala His Trp Pro Glu His Met Lys Ser Cys
625                 630                 635                 640 
Thr Gln Ser Ala Thr Ala Pro Gln Gln Glu Ala Asp Ala Glu Val Asn
                645                 650                 655     
Thr Glu Thr Leu Asn Lys Ser Ser Gln Gly Ser Ser Ser Ser Thr Gln
            660                 665                 670         
Ser Ala Pro Ser Glu Thr Ala Ser Ala Ser Lys Glu Lys Glu Thr Ser
        675                 680                 685             
Ala Glu Lys Ser Lys Glu Ser Gly Ser Thr Leu Asp Leu Ser Gly Ser
    690                 695                 700                 
Arg Glu Thr Pro Ser Ser Ile Leu Leu Gly Ser Asn Gln Gly Ser Asp
705                 710                 715                 720 
His Ser Arg Ser Asn Lys Ser Ser Trp Ser Ser Ser Asp Glu Lys Arg
                725                 730                 735     
Gly Ser Thr Arg Ser Asp His Asn Thr Ser Thr Ser Thr Lys Ser Leu
            740                 745                 750         
Leu Pro Lys Glu Ser Arg Leu Asp Thr Phe Trp Asp
        755                 760                 


<210> 6677
<211> 1920
<212> PRT
<213> Homo sapiens

<400> 6677
His Thr Gln Lys Pro Asp Glu Gln Arg Ser Glu Pro Ser Ala Gly Ile
 1               5                  10                  15      
Pro Lys Val Thr Ser Arg Cys Ile Asp Ser Lys Glu Pro Ile Glu Arg
            20                  25                  30          
Pro Glu Glu Lys Pro Lys Lys Glu Gly Phe Ile Arg Ser Ser Glu Gly
        35                  40                  45              
Pro Lys Pro Glu Lys Val Tyr Lys Ser Lys Ser Glu Thr Arg Trp Gly
    50                  55                  60                  
Pro Arg Pro Ser Ser Asn Arg Arg Glu Glu Val Asn Asp Arg Pro Val
65                  70                  75                  80  
Arg Arg Ser Gly Pro Ile Lys Lys Pro Val Leu Arg Asp Met Lys Glu
                85                  90                  95      
Glu Arg Glu Gln Arg Lys Glu Lys Glu Gly Glu Lys Ala Glu Lys Val
            100                 105                 110         
Thr Glu Lys Val Val Val Lys Pro Glu Lys Thr Glu Lys Lys Asp Leu
        115                 120                 125             
Pro Pro Pro Pro Pro Pro Pro Gln Pro Pro Ala Pro Ile Gln Pro Gln
    130                 135                 140                 
Ser Val Pro Pro Pro Ile Gln Pro Glu Ala Glu Lys Phe Pro Ser Thr
145                 150                 155                 160 
Glu Thr Ala Thr Leu Ala Gln Lys Pro Ser Gln Asp Thr Glu Lys Pro
                165                 170                 175     
Leu Glu Pro Val Ser Thr Val Gln Val Glu Pro Ala Val Lys Thr Val
            180                 185                 190         
Asn Gln Gln Thr Met Ala Ala Pro Val Val Lys Glu Glu Lys Gln Pro
        195                 200                 205             
Glu Lys Val Ile Ser Lys Asp Leu Val Ile Glu Arg Pro Arg Pro Asp
    210                 215                 220                 
Ser Arg Pro Ala Val Lys Lys Glu Ser Thr Leu Pro Pro Arg Thr Tyr
225                 230                 235                 240 
Trp Lys Glu Ala Arg Glu Arg Asp Trp Phe Pro Asp Gln Gly Tyr Arg
                245                 250                 255     
Gly Arg Gly Arg Gly Glu Tyr Tyr Ser Arg Gly Arg Ser Tyr Arg Gly
            260                 265                 270         
Ser Tyr Gly Gly Arg Gly Arg Gly Gly Arg Gly His Thr Arg Asp Tyr
        275                 280                 285             
Pro Gln Tyr Arg Asp Asn Lys Pro Arg Ala Glu His Ile Pro Ser Gly
    290                 295                 300                 
Pro Leu Arg Gln Arg Glu Glu Ser Glu Thr Arg Ser Glu Ser Ser Asp
305                 310                 315                 320 
Phe Glu Val Val Pro Lys Arg Arg Arg Gln Arg Gly Ser Glu Thr Asp
                325                 330                 335     
Thr Asp Ser Glu Ile His Glu Ser Ala Ser Asp Lys Asp Ser Leu Ser
            340                 345                 350         
Lys Gly Lys Leu Pro Lys Arg Glu Glu Arg Pro Glu Asn Lys Lys Pro
        355                 360                 365             
Val Lys Pro His Ser Ser Phe Lys Pro Asp Asn His Val Arg Ile Asp
    370                 375                 380                 
Asn Arg Leu Leu Glu Lys Pro Tyr Val Arg Asp Asp Asp Lys Ala Lys
385                 390                 395                 400 
Pro Gly Phe Leu Pro Lys Gly Glu Pro Thr Arg Arg Gly Arg Gly Gly
                405                 410                 415     
Thr Phe Arg Arg Gly Gly Arg Asp Pro Gly Gly Arg Pro Ser Arg Pro
            420                 425                 430         
Ser Thr Leu Arg Arg Pro Ala Tyr Arg Asp Asn Gln Trp Asn Pro Arg
        435                 440                 445             
Gln Ser Glu Val Pro Lys Pro Glu Asp Gly Glu Pro Pro Arg Arg His
    450                 455                 460                 
Glu Gln Phe Ile Pro Ile Ala Ala Asp Lys Arg Pro Pro Lys Phe Glu
465                 470                 475                 480 
Arg Lys Phe Asp Pro Ala Arg Glu Arg Pro Arg Arg Gln Arg Pro Thr
                485                 490                 495     
Arg Pro Pro Arg Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu Arg Glu
            500                 505                 510         
Arg Glu Ala Ala Ser Lys Ser Asn Glu Val Val Ala Val Pro Thr Asn
        515                 520                 525             
Gly Thr Val Asn Asn Val Ala Gln Glu Pro Val Asn Thr Leu Gly Asp
    530                 535                 540                 
Ile Ser Gly Asn Lys Thr Pro Asp Leu Ser Asn Gln Asn Ser Ser Asp
545                 550                 555                 560 
Gln Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu Ser Ser Asp Phe Asn
                565                 570                 575     
Glu Arg Arg Glu Arg Asp Glu Lys Lys Asn Ala Asp Leu Asn Ala Gln
            580                 585                 590         
Thr Val Val Lys Val Gly Glu Asn Val Leu Pro Pro Lys Arg Glu Ile
        595                 600                 605             
Ala Lys Arg Ser Phe Ser Ser Gln Arg Pro Val Asp Arg Gln Asn Arg
    610                 615                 620                 
Arg Gly Asn Asn Gly Pro Pro Lys Ser Gly Arg Asn Phe Ser Gly Pro
625                 630                 635                 640 
Arg Asn Glu Arg Arg Ser Gly Pro Pro Ser Lys Ser Gly Lys Arg Gly
                645                 650                 655     
Pro Phe Asp Asp Gln Pro Ala Gly Thr Thr Gly Val Asp Leu Ile Asn
            660                 665                 670         
Gly Ser Ser Ala His His Gln Glu Gly Val Pro Asn Gly Thr Gly Gln
        675                 680                 685             
Lys Asn Ser Lys Asp Ser Thr Gly Lys Lys Arg Glu Asp Pro Lys Pro
    690                 695                 700                 
Gly Pro Lys Lys Pro Lys Glu Lys Val Asp Ala Leu Ser Gln Phe Asp
705                 710                 715                 720 
Leu Asn Asn Tyr Ala Ser Val Val Ile Ile Asp Asp His Pro Glu Val
                725                 730                 735     
Thr Val Ile Glu Asp Pro Gln Ser Asn Leu Asn Asp Asp Gly Phe Thr
            740                 745                 750         
Glu Val Val Ser Lys Lys Gln Gln Lys Arg Leu Gln Asp Glu Glu Arg
        755                 760                 765             
Arg Lys Lys Glu Glu Gln Val Ile Gln Val Trp Asn Lys Lys Asn Ala
    770                 775                 780                 
Asn Glu Lys Gly Arg Ser Gln Thr Ser Lys Leu Pro Pro Arg Phe Ala
785                 790                 795                 800 
Lys Lys Gln Ala Thr Gly Ile Gln Gln Ala Gln Ser Ser Ala Ser Val
                805                 810                 815     
Pro Pro Leu Ala Ser Ala Pro Leu Pro Pro Ser Thr Ser Ser Pro Leu
            820                 825                 830         
Ala Pro Val Ser Ala Ser Ala Ser Val Ser Ala Ser Val Pro Ala Ser
        835                 840                 845             
Thr Ser Ala Ala Ala Ile Thr Ser Ser Ser Ala Pro Ala Ser Ala Pro
    850                 855                 860                 
Ala Pro Thr Pro Ile Leu Ala Ser Val Ser Thr Pro Ala Ser Val Thr
865                 870                 875                 880 
Ile Leu Ala Ser Ala Ser Ile Pro Ile Leu Ala Ser Ala Leu Ala Ser
                885                 890                 895     
Thr Ser Ala Pro Thr Pro Ala Pro Ala Ala Ser Ser Pro Ala Ala Pro
            900                 905                 910         
Val Ile Thr Ala Pro Thr Ile Pro Ala Ser Ala Pro Thr Ala Ser Val
        915                 920                 925             
Pro Leu Ala Pro Ala Ser Ala Ser Ala Pro Ala Pro Ala Pro Thr Pro
    930                 935                 940                 
Val Ser Ala Pro Asn Pro Ala Pro Pro Ala Pro Ala Gln Thr Gln Ala
945                 950                 955                 960 
Gln Thr His Lys Pro Val Gln Asn Pro Leu Gln Thr Thr Ser Gln Ser
                965                 970                 975     
Ser Lys Gln Pro Pro Pro Ser Ile Arg Leu Pro Ser Ala Gln Thr Pro
            980                 985                 990         
Asn Gly Thr Asp Tyr Val Ala Ser Gly Lys Ser Ile Gln Thr Pro Gln
        995                 1000                1005            
Ser His Gly Thr Leu Thr Ala Glu Leu Trp Asp Asn Lys Val Ala Pro
    1010                1015                1020                
Pro Ala Val Leu Asn Asp Ile Ser Lys Lys Leu Gly Pro Ile Ser Pro
1025                1030                1035                1040
Pro Gln Pro Pro Ser Val Ser Ala Trp Asn Lys Pro Leu Thr Ser Phe
                1045                1050                1055    
Gly Ser Ala Pro Ser Ser Glu Gly Ala Lys Asn Gly Gln Glu Ser Gly
            1060                1065                1070        
Leu Glu Ile Gly Thr Asp Thr Ile Gln Phe Gly Ala Pro Ala Ser Asn
        1075                1080                1085            
Gly Asn Glu Asn Glu Val Val Pro Val Leu Ser Glu Lys Ser Ala Asp
    1090                1095                1100                
Lys Ile Pro Glu Pro Lys Glu Gln Arg Gln Lys Gln Pro Arg Ala Gly
1105                1110                1115                1120
Pro Ile Lys Ala Gln Lys Leu Pro Asp Leu Ser Pro Val Glu Asn Lys
                1125                1130                1135    
Glu His Lys Pro Gly Pro Ile Gly Lys Glu Arg Ser Leu Lys Asn Arg
            1140                1145                1150        
Lys Val Lys Asp Ala Gln Gln Val Glu Pro Glu Gly Gln Glu Lys Pro
        1155                1160                1165            
Ser Pro Ala Thr Val Arg Ser Thr Asp Pro Val Thr Thr Lys Glu Thr
    1170                1175                1180                
Lys Ala Val Ser Glu Met Ser Thr Glu Ile Gly Thr Met Ile Ser Val
1185                1190                1195                1200
Ser Ser Ala Glu Tyr Gly Thr Asn Ala Lys Glu Ser Val Thr Asp Tyr
                1205                1210                1215    
Thr Thr Pro Ser Ser Ser Leu Pro Asn Thr Val Ala Thr Asn Asn Thr
            1220                1225                1230        
Lys Met Glu Asp Thr Leu Val Asn Asn Val Pro Leu Pro Asn Thr Leu
        1235                1240                1245            
Pro Leu Pro Lys Arg Glu Thr Ile Gln Gln Ser Ser Ser Leu Thr Ser
    1250                1255                1260                
Val Pro Pro Thr Thr Phe Ser Leu Thr Phe Lys Met Glu Ser Ala Arg
1265                1270                1275                1280
Lys Ala Trp Glu Asn Ser Pro Asn Val Arg Glu Lys Gly Ser Pro Val
                1285                1290                1295    
Thr Ser Thr Ala Pro Pro Ile Ala Thr Gly Val Ser Ser Ser Ala Ser
            1300                1305                1310        
Gly Pro Ser Thr Ala Asn Tyr Asn Ser Phe Ser Ser Ala Ser Met Pro
        1315                1320                1325            
Gln Ile Pro Val Ala Ser Val Thr Pro Thr Ala Ser Leu Ser Gly Ala
    1330                1335                1340                
Gly Thr Tyr Thr Thr Ser Ser Leu Ser Thr Lys Ser Thr Thr Thr Ser
1345                1350                1355                1360
Asp Pro Pro Asn Ile Cys Lys Val Lys Pro Gln Gln Leu Gln Thr Ser
                1365                1370                1375    
Ser Leu Pro Ser Ala Ser His Phe Ser Gln Leu Ser Cys Met Pro Ser
            1380                1385                1390        
Leu Ile Ala Gln Gln Gln Gln Asn Pro Gln Val Tyr Val Ser Gln Ser
        1395                1400                1405            
Ala Ala Ala Gln Ile Pro Ala Phe Tyr Met Asp Thr Ser His Leu Phe
    1410                1415                1420                
Asn Thr Gln His Ala Arg Leu Ala Pro Pro Ser Leu Ala Gln Gln Gln
1425                1430                1435                1440
Gly Phe Gln Pro Gly Leu Ser Gln Pro Thr Ser Val Gln Gln Ile Pro
                1445                1450                1455    
Ile Pro Ile Tyr Ala Pro Leu Gln Gly Gln His Gln Ala Gln Leu Ser
            1460                1465                1470        
Leu Gly Ala Gly Pro Ala Val Ser Gln Ala Gln Glu Leu Phe Ser Ser
        1475                1480                1485            
Ser Leu Gln Pro Tyr Arg Ser Gln Pro Ala Phe Met Gln Ser Ser Leu
    1490                1495                1500                
Ser Gln Pro Ser Val Val Leu Ser Gly Thr Ala Ile His Asn Phe Pro
1505                1510                1515                1520
Thr Val Gln His Gln Glu Leu Ala Lys Ala Gln Ser Gly Leu Ala Phe
                1525                1530                1535    
Gln Gln Thr Ser Asn Thr Gln Pro Ile Pro Ile Leu Tyr Glu His Gln
            1540                1545                1550        
Leu Gly Gln Ala Ser Gly Leu Gly Gly Ser Gln Leu Ile Asp Thr His
        1555                1560                1565            
Leu Leu Gln Ala Arg Ala Asn Leu Thr Gln Ala Ser Asn Leu Tyr Ser
    1570                1575                1580                
Gly Gln Val Gln Gln Pro Gly Gln Thr Asn Phe Tyr Asn Thr Ala Gln
1585                1590                1595                1600
Ser Pro Ser Ala Leu Gln Gln Val Thr Val Pro Leu Pro Ala Ser Gln
                1605                1610                1615    
Leu Ser Leu Pro Asn Phe Gly Ser Thr Gly Gln Pro Leu Ile Ala Leu
            1620                1625                1630        
Pro Gln Thr Leu Gln Pro Pro Leu Gln His Thr Thr Pro Gln Ala Gln
        1635                1640                1645            
Ala Gln Ser Leu Ser Arg Pro Ala Gln Val Ser Gln Pro Phe Arg Gly
    1650                1655                1660                
Leu Ile Pro Ala Gly Thr Gln His Ser Met Ile Ala Thr Thr Gly Lys
1665                1670                1675                1680
Met Ser Glu Met Glu Leu Lys Ala Phe Gly Ser Gly Ile Asp Ile Lys
                1685                1690                1695    
Pro Gly Thr Pro Pro Ile Ala Gly Arg Ser Thr Thr Pro Thr Ser Ser
            1700                1705                1710        
Pro Ala Thr Ser Thr Ser Pro Asn Ser Gln Ser Ser Lys Met Asn Ser
        1715                1720                1725            
Ile Val Tyr Gln Lys Gln Phe Gln Ser Ala Pro Ala Thr Val Arg Met
    1730                1735                1740                
Thr Gln Pro Phe Pro Thr Gln Phe Ala Pro Gln Ile Leu Ser Gln Pro
1745                1750                1755                1760
Asn Leu Val Pro Pro Leu Val Arg Ala Pro His Thr Asn Thr Phe Pro
                1765                1770                1775    
Ala Pro Val Gln Arg Pro Pro Met Ala Leu Ala Ser Gln Met Pro Pro
            1780                1785                1790        
Pro Leu Thr Thr Gly Leu Met Ser His Ala Arg Leu Pro His Val Ala
        1795                1800                1805            
Arg Gly Pro Cys Gly Ser Leu Ser Gly Val Arg Gly Asn Gln Ala Gln
    1810                1815                1820                
Ala Ala Leu Lys Ala Glu Gln Asp Met Lys Ala Lys Gln Arg Ala Glu
1825                1830                1835                1840
Val Leu Gln Ser Thr Gln Arg Phe Phe Ser Glu Gln Gln Gln Ser Lys
                1845                1850                1855    
Gln Ile Gly Gly Gly Lys Ala Gln Lys Val Asp Ser Asp Ser Ser Lys
            1860                1865                1870        
Pro Pro Glu Thr Leu Thr Asp Pro Pro Gly Val Cys Gln Glu Lys Val
        1875                1880                1885            
Glu Glu Lys Pro Pro Pro Ala Pro Ser Ile Ala Thr Lys Pro Val Arg
    1890                1895                1900                
Thr Gly Pro Ile Lys Pro Gln Ala Ile Lys Thr Glu Glu Thr Lys Ser
1905                1910                1915                1920


<210> 6678
<211> 2701
<212> PRT
<213> Homo sapiens

<400> 6678
Met Ser Glu Lys Ser Gly Gln Ser Thr Lys Ala Lys Asp Gly Lys Lys
 1               5                  10                  15      
Tyr Ala Thr Leu Ser Leu Phe Asn Thr Tyr Lys Gly Lys Ser Leu Glu
            20                  25                  30          
Thr Gln Lys Thr Thr Ala Arg His Gly Leu Gln Ser Leu Gly Lys Val
        35                  40                  45              
Gly Ile Ser Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser Leu Lys
    50                  55                  60                  
Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Asn Ile Val Pro Lys Asp
65                  70                  75                  80  
Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln His Glu Glu Glu Lys Thr
                85                  90                  95      
Pro Glu Val Pro Pro Ala Gln Pro Lys Pro Gly Val Ala Ala Pro Pro
            100                 105                 110         
Glu Val Ala Pro Ala Pro Lys Ser Trp Ala Ser Asn Lys Gln Gly Gly
        115                 120                 125             
Gln Gly Asp Gly Ile Gln Val Asn Ser Gln Phe Gln Gln Glu Phe Pro
    130                 135                 140                 
Ser Leu Gln Ala Ala Gly Asp Gln Glu Lys Lys Glu Lys Glu Thr Asn
145                 150                 155                 160 
Asp Asp Asn Tyr Gly Pro Gly Pro Ser Leu Arg Pro Pro Asn Val Ala
                165                 170                 175     
Cys Trp Arg Asp Gly Gly Lys Ala Ala Gly Ser Pro Ser Ser Ser Asp
            180                 185                 190         
Gln Asp Glu Lys Leu Pro Gly Gln Asp Glu Ser Thr Ala Gly Thr Ser
        195                 200                 205             
Glu Gln Asn Asp Ile Leu Lys Val Val Glu Lys Arg Ile Ala Cys Gly
    210                 215                 220                 
Pro Pro Gln Ala Lys Leu Asn Gly Gln Gln Ala Ala Leu Ala Ser Gln
225                 230                 235                 240 
Tyr Arg Ala Met Met Pro Pro Tyr Met Phe Gln Gln Tyr Pro Arg Met
                245                 250                 255     
Thr Tyr Pro Pro Leu His Gly Pro Met Arg Phe Pro Pro Ser Leu Ser
            260                 265                 270         
Glu Thr Asn Lys Gly Leu Arg Gly Arg Gly Pro Pro Pro Ser Trp Ala
        275                 280                 285             
Ser Glu Pro Glu Arg Pro Ser Ile Leu Ser Ala Ser Glu Leu Lys Glu
    290                 295                 300                 
Leu Asp Lys Phe Asp Asn Leu Asp Ala Glu Ala Asp Glu Gly Trp Ala
305                 310                 315                 320 
Gly Ala Gln Met Glu Val Asp Tyr Thr Glu Gln Leu Asn Phe Ser Asp
                325                 330                 335     
Asp Asp Glu Gln Gly Ser Asn Ser Pro Lys Glu Asn Asn Ser Glu Asp
            340                 345                 350         
Gln Gly Ser Lys Ala Ser Glu Asn Asn Glu Asn Lys Lys Glu Thr Asp
        355                 360                 365             
Glu Val Ser Asn Thr Lys Ser Ser Ser Gln Ile Pro Ala Gln Pro Ser
    370                 375                 380                 
Val Ala Lys Val Pro Tyr Gly Lys Gly Pro Ser Phe Asn Gln Glu Arg
385                 390                 395                 400 
Gly Thr Ser Ser His Leu Pro Pro Pro Pro Lys Leu Leu Ala Gln Gln
                405                 410                 415     
His Pro Pro Pro Asp Arg Gln Ala Val Pro Gly Arg Pro Gly Pro Phe
            420                 425                 430         
Pro Ser Lys Gln Gln Val Ala Asp Glu Asp Glu Ile Trp Lys Gln Arg
        435                 440                 445             
Arg Arg Gln Gln Ser Glu Ile Ser Ala Ala Val Glu Arg Ala Arg Lys
    450                 455                 460                 
Arg Arg Glu Glu Glu Glu Arg Arg Met Glu Glu Gln Arg Lys Ala Ala
465                 470                 475                 480 
Cys Ala Glu Lys Leu Lys Arg Leu Asp Glu Lys Leu Gly Ile Leu Glu
                485                 490                 495     
Lys Gln Pro Ser Pro Glu Glu Ile Arg Glu Arg Glu Arg Glu Lys Glu
            500                 505                 510         
Arg Glu Arg Glu Lys Glu Leu Glu Lys Glu Gln Glu Gln Glu Arg Glu
        515                 520                 525             
Lys Glu Arg Glu Lys Asp Arg Glu Arg Gln Gln Glu Lys Glu Lys Glu
    530                 535                 540                 
Leu Glu Lys Glu Gln Glu Lys Gln Arg Glu Met Glu Lys Glu Arg Lys
545                 550                 555                 560 
Gln Glu Lys Glu Lys Glu Leu Glu Arg Gln Lys Glu Lys Glu Lys Glu
                565                 570                 575     
Leu Gln Lys Met Lys Glu Gln Glu Lys Glu Cys Glu Leu Glu Lys Glu
            580                 585                 590         
Arg Glu Lys Leu Glu Glu Lys Ile Glu Pro Arg Glu Pro Asn Leu Glu
        595                 600                 605             
Pro Met Val Glu Lys Gln Glu Ser Glu Asn Ser Cys Asn Lys Glu Glu
    610                 615                 620                 
Glu Pro Val Phe Thr Arg Gln Asp Ser Asn Arg Ser Glu Lys Glu Ala
625                 630                 635                 640 
Thr Pro Val Val His Glu Thr Glu Pro Glu Ser Gly Ser Gln Pro Arg
                645                 650                 655     
Pro Ala Val Leu Ser Gly Tyr Phe Lys Gln Phe Gln Lys Ser Leu Pro
            660                 665                 670         
Pro Arg Phe Gln Arg Gln Gln Glu Gln Met Lys Gln Gln Gln Trp Gln
        675                 680                 685             
Gln Gln Gln Gln Gln Gly Val Leu Pro Gln Thr Val Pro Ser Gln Pro
    690                 695                 700                 
Ser Ser Ser Thr Val Pro Pro Pro Pro His Arg Pro Leu Tyr Gln Pro
705                 710                 715                 720 
Met Gln Pro His Pro Gln His Leu Ala Ser Met Gly Phe Asp Pro Arg
                725                 730                 735     
Trp Leu Met Met Gln Ser Tyr Met Asp Pro Arg Met Met Ser Gly Arg
            740                 745                 750         
Pro Ala Met Asp Ile Pro Pro Ile His Pro Gly Met Ile Pro Pro Lys
        755                 760                 765             
Pro Leu Met Arg Arg Asp Gln Met Glu Gly Ser Pro Asn Ser Ser Glu
    770                 775                 780                 
Ser Phe Glu His Ile Ala Arg Ser Ala Arg Asp His Ala Ile Ser Leu
785                 790                 795                 800 
Ser Glu Pro Arg Met Leu Trp Gly Ser Asp Pro Tyr Pro His Ala Glu
                805                 810                 815     
Pro Gln Gln Ala Thr Thr Pro Lys Ala Thr Glu Glu Pro Glu Asp Val
            820                 825                 830         
Arg Ser Glu Ala Ala Leu Asp Gln Glu Gln Ile Thr Ala Ala Tyr Ser
        835                 840                 845             
Val Glu His Asn Gln Leu Glu Ala His Pro Lys Ala Asp Phe Ile Arg
    850                 855                 860                 
Glu Ser Ser Glu Ala Gln Val Gln Lys Phe Leu Ser Arg Ser Val Glu
865                 870                 875                 880 
Asp Val Arg Pro His His Thr Asp Ala Asn Asn Gln Ser Ala Cys Phe
                885                 890                 895     
Glu Ala Pro Asp Gln Lys Thr Leu Ser Ala Pro Gln Glu Glu Arg Ile
            900                 905                 910         
Ser Ala Val Glu Ser Gln Pro Ser Arg Lys Arg Ser Val Ser His Gly
        915                 920                 925             
Ser Asn His Thr Gln Lys Pro Asp Glu Gln Arg Ser Glu Pro Ser Ala
    930                 935                 940                 
Gly Ile Pro Lys Val Thr Ser Arg Cys Ile Asp Ser Lys Glu Pro Ile
945                 950                 955                 960 
Glu Arg Pro Glu Glu Lys Pro Lys Lys Glu Gly Phe Ile Arg Ser Ser
                965                 970                 975     
Glu Gly Pro Lys Pro Glu Lys Val Tyr Lys Ser Lys Ser Glu Thr Arg
            980                 985                 990         
Trp Gly Pro Arg Pro Ser Ser Asn Arg Arg Glu Glu Val Asn Asp Arg
        995                 1000                1005            
Pro Val Arg Arg Ser Gly Pro Ile Lys Lys Pro Val Leu Arg Asp Met
    1010                1015                1020                
Lys Glu Glu Arg Glu Gln Arg Lys Glu Lys Glu Gly Glu Lys Ala Glu
1025                1030                1035                1040
Lys Val Thr Glu Lys Val Val Val Lys Pro Glu Lys Thr Glu Lys Lys
                1045                1050                1055    
Asp Leu Pro Pro Pro Pro Pro Pro Pro Gln Pro Pro Ala Pro Ile Gln
            1060                1065                1070        
Pro Gln Ser Val Pro Pro Pro Ile Gln Pro Glu Ala Glu Lys Phe Pro
        1075                1080                1085            
Ser Thr Glu Thr Ala Thr Leu Ala Gln Lys Pro Ser Gln Asp Thr Glu
    1090                1095                1100                
Lys Pro Leu Glu Pro Val Ser Thr Val Gln Val Glu Pro Ala Val Lys
1105                1110                1115                1120
Thr Val Asn Gln Gln Thr Met Ala Ala Pro Val Val Lys Glu Glu Lys
                1125                1130                1135    
Gln Pro Glu Lys Val Ile Ser Lys Asp Leu Val Ile Glu Arg Pro Arg
            1140                1145                1150        
Pro Asp Ser Arg Pro Ala Val Lys Lys Glu Ser Thr Leu Pro Pro Arg
        1155                1160                1165            
Thr Tyr Trp Lys Glu Ala Arg Glu Arg Asp Trp Phe Pro Asp Gln Gly
    1170                1175                1180                
Tyr Arg Gly Arg Gly Arg Gly Glu Tyr Tyr Ser Arg Gly Arg Ser Tyr
1185                1190                1195                1200
Arg Gly Ser Tyr Gly Gly Arg Gly Arg Gly Gly Arg Gly His Thr Arg
                1205                1210                1215    
Asp Tyr Pro Gln Tyr Arg Asp Asn Lys Pro Arg Ala Glu His Ile Pro
            1220                1225                1230        
Ser Gly Pro Leu Arg Gln Arg Glu Glu Ser Glu Thr Arg Ser Glu Ser
        1235                1240                1245            
Ser Asp Phe Glu Val Val Pro Lys Arg Arg Arg Gln Arg Gly Ser Glu
    1250                1255                1260                
Thr Asp Thr Asp Ser Glu Ile His Glu Ser Ala Ser Asp Lys Asp Ser
1265                1270                1275                1280
Leu Ser Lys Gly Lys Leu Pro Lys Arg Glu Glu Arg Pro Glu Asn Lys
                1285                1290                1295    
Lys Pro Val Lys Pro His Ser Ser Phe Lys Pro Asp Asn His Val Arg
            1300                1305                1310        
Ile Asp Asn Arg Leu Leu Glu Lys Pro Tyr Val Arg Asp Asp Asp Lys
        1315                1320                1325            
Ala Lys Pro Gly Phe Leu Pro Lys Gly Glu Pro Thr Arg Arg Gly Arg
    1330                1335                1340                
Gly Gly Thr Phe Arg Arg Gly Gly Arg Asp Pro Gly Gly Arg Pro Ser
1345                1350                1355                1360
Arg Pro Ser Thr Leu Arg Arg Pro Ala Tyr Arg Asp Asn Gln Trp Asn
                1365                1370                1375    
Pro Arg Gln Ser Glu Val Pro Lys Pro Glu Asp Gly Glu Pro Pro Arg
            1380                1385                1390        
Arg His Glu Gln Phe Ile Pro Ile Ala Ala Asp Lys Arg Pro Pro Lys
        1395                1400                1405            
Phe Glu Arg Lys Phe Asp Pro Ala Arg Glu Arg Pro Arg Arg Gln Arg
    1410                1415                1420                
Pro Thr Arg Pro Pro Arg Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu
1425                1430                1435                1440
Arg Glu Arg Glu Ala Ala Ser Lys Ser Asn Glu Val Val Ala Val Pro
                1445                1450                1455    
Thr Asn Gly Thr Val Asn Asn Val Ala Gln Glu Pro Val Asn Thr Leu
            1460                1465                1470        
Gly Asp Ile Ser Gly Asn Lys Thr Pro Asp Leu Ser Asn Gln Asn Ser
        1475                1480                1485            
Ser Asp Gln Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu Ser Ser Asp
    1490                1495                1500                
Phe Asn Glu Arg Arg Glu Arg Asp Glu Lys Lys Asn Ala Asp Leu Asn
1505                1510                1515                1520
Ala Gln Thr Val Val Lys Val Gly Glu Asn Val Leu Pro Pro Lys Arg
                1525                1530                1535    
Glu Ile Ala Lys Arg Ser Phe Ser Ser Gln Arg Pro Val Asp Arg Gln
            1540                1545                1550        
Asn Arg Arg Gly Asn Asn Gly Pro Pro Lys Ser Gly Arg Asn Phe Ser
        1555                1560                1565            
Gly Pro Arg Asn Glu Arg Arg Ser Gly Pro Pro Ser Lys Ser Gly Lys
    1570                1575                1580                
Arg Gly Pro Phe Asp Asp Gln Pro Ala Gly Thr Thr Gly Val Asp Leu
1585                1590                1595                1600
Ile Asn Gly Ser Ser Ala His His Gln Glu Gly Val Pro Asn Gly Thr
                1605                1610                1615    
Gly Gln Lys Asn Ser Lys Asp Ser Thr Gly Lys Lys Arg Glu Asp Pro
            1620                1625                1630        
Lys Pro Gly Pro Lys Lys Pro Lys Glu Lys Val Asp Ala Leu Ser Gln
        1635                1640                1645            
Phe Asp Leu Asn Asn Tyr Ala Ser Val Val Ile Ile Asp Asp His Pro
    1650                1655                1660                
Glu Val Thr Val Ile Glu Asp Pro Gln Ser Asn Leu Asn Asp Asp Gly
1665                1670                1675                1680
Phe Thr Glu Val Val Ser Lys Lys Gln Gln Lys Arg Leu Gln Asp Glu
                1685                1690                1695    
Glu Arg Arg Lys Lys Glu Glu Gln Val Ile Gln Val Trp Asn Lys Lys
            1700                1705                1710        
Asn Ala Asn Glu Lys Gly Arg Ser Gln Thr Ser Lys Leu Pro Pro Arg
        1715                1720                1725            
Phe Ala Lys Lys Gln Ala Thr Gly Ile Gln Gln Ala Gln Ser Ser Ala
    1730                1735                1740                
Ser Val Pro Pro Leu Ala Ser Ala Pro Leu Pro Pro Ser Thr Ser Ala
1745                1750                1755                1760
Ser Val Pro Ala Ser Thr Ser Ala Pro Leu Pro Ala Thr Leu Thr Pro
                1765                1770                1775    
Val Pro Ala Ser Thr Ser Ala Pro Val Pro Ala Ser Thr Leu Ala Pro
            1780                1785                1790        
Val Leu Ala Ser Thr Ser Ala Pro Val Pro Ala Ser Pro Leu Ala Pro
        1795                1800                1805            
Val Ser Ala Ser Ala Ser Val Ser Ala Ser Val Pro Ala Ser Thr Ser
    1810                1815                1820                
Ala Ala Ala Ile Thr Ser Ser Ser Ala Pro Ala Ser Ala Pro Ala Pro
1825                1830                1835                1840
Thr Pro Ile Leu Ala Ser Val Ser Thr Pro Ala Ser Val Thr Ile Leu
                1845                1850                1855    
Ala Ser Ala Ser Ile Pro Ile Leu Ala Ser Ala Leu Ala Ser Thr Ser
            1860                1865                1870        
Ala Pro Thr Pro Ala Pro Ala Ala Ser Ser Pro Ala Ala Pro Val Ile
        1875                1880                1885            
Thr Ala Pro Thr Ile Pro Ala Ser Ala Pro Thr Ala Ser Val Pro Leu
    1890                1895                1900                
Ala Pro Ala Ser Ala Ser Ala Pro Ala Pro Ala Pro Thr Pro Val Ser
1905                1910                1915                1920
Ala Pro Asn Pro Ala Pro Pro Ala Pro Ala Gln Thr Gln Ala Gln Thr
                1925                1930                1935    
His Lys Pro Val Gln Asn Pro Leu Gln Thr Thr Ser Gln Ser Ser Lys
            1940                1945                1950        
Gln Pro Pro Pro Ser Ile Arg Leu Pro Ser Ala Gln Thr Pro Asn Gly
        1955                1960                1965            
Thr Asp Tyr Val Ala Ser Gly Lys Ser Ile Gln Thr Pro Gln Ser His
    1970                1975                1980                
Gly Thr Leu Thr Ala Glu Leu Trp Asp Asn Lys Val Ala Pro Pro Ala
1985                1990                1995                2000
Val Leu Asn Asp Ile Ser Lys Lys Leu Gly Pro Ile Ser Pro Pro Gln
                2005                2010                2015    
Pro Pro Ser Val Ser Ala Trp Asn Lys Pro Leu Thr Ser Phe Gly Ser
            2020                2025                2030        
Ala Pro Ser Ser Glu Gly Ala Lys Asn Gly Gln Glu Ser Gly Leu Glu
        2035                2040                2045            
Ile Gly Thr Asp Thr Ile Gln Phe Gly Ala Pro Ala Ser Asn Gly Asn
    2050                2055                2060                
Glu Asn Glu Val Val Pro Val Leu Ser Glu Lys Ser Ala Asp Lys Ile
2065                2070                2075                2080
Pro Glu Pro Lys Glu Gln Arg Gln Lys Gln Pro Arg Ala Gly Pro Ile
                2085                2090                2095    
Lys Ala Gln Lys Leu Pro Asp Leu Ser Pro Val Glu Asn Lys Glu His
            2100                2105                2110        
Lys Pro Gly Pro Ile Gly Lys Glu Arg Ser Leu Lys Asn Arg Lys Val
        2115                2120                2125            
Lys Asp Ala Gln Gln Val Glu Pro Glu Gly Gln Glu Lys Pro Ser Pro
    2130                2135                2140                
Ala Thr Val Arg Ser Thr Asp Pro Val Thr Thr Lys Glu Thr Lys Ala
2145                2150                2155                2160
Val Ser Glu Met Ser Thr Glu Ile Gly Thr Met Ile Ser Val Ser Ser
                2165                2170                2175    
Ala Glu Tyr Gly Thr Asn Ala Lys Glu Ser Val Thr Asp Tyr Thr Thr
            2180                2185                2190        
Pro Ser Ser Ser Leu Pro Asn Thr Val Ala Thr Asn Asn Thr Lys Met
        2195                2200                2205            
Glu Asp Thr Leu Val Asn Asn Val Pro Leu Pro Asn Thr Leu Pro Leu
    2210                2215                2220                
Pro Lys Arg Glu Thr Ile Gln Gln Ser Ser Ser Leu Thr Ser Val Pro
2225                2230                2235                2240
Pro Thr Thr Phe Ser Leu Thr Phe Lys Met Glu Ser Ala Arg Lys Ala
                2245                2250                2255    
Trp Glu Asn Ser Pro Asn Val Arg Glu Lys Gly Ser Pro Val Thr Ser
            2260                2265                2270        
Thr Ala Pro Pro Ile Ala Thr Gly Val Ser Ser Ser Ala Ser Gly Pro
        2275                2280                2285            
Ser Thr Ala Asn Tyr Asn Ser Phe Ser Ser Ala Ser Met Pro Gln Ile
    2290                2295                2300                
Pro Val Ala Ser Val Thr Pro Thr Ala Ser Leu Ser Gly Ala Gly Thr
2305                2310                2315                2320
Tyr Thr Thr Ser Ser Leu Ser Thr Lys Ser Thr Thr Thr Ser Asp Pro
                2325                2330                2335    
Pro Asn Ile Cys Lys Val Lys Pro Gln Gln Leu Gln Thr Ser Ser Leu
            2340                2345                2350        
Pro Ser Ala Ser His Phe Ser Gln Leu Ser Cys Met Pro Ser Leu Ile
        2355                2360                2365            
Ala Gln Gln Gln Gln Asn Pro Gln Val Tyr Val Ser Gln Ser Ala Ala
    2370                2375                2380                
Ala Gln Ile Pro Ala Phe Tyr Met Asp Thr Ser His Leu Phe Asn Thr
2385                2390                2395                2400
Gln His Ala Arg Leu Ala Pro Pro Ser Leu Ala Gln Gln Gln Gly Phe
                2405                2410                2415    
Gln Pro Gly Leu Ser Gln Pro Thr Ser Val Gln Gln Ile Pro Ile Pro
            2420                2425                2430        
Ile Tyr Ala Pro Leu Gln Gly Gln His Gln Ala Gln Leu Ser Leu Gly
        2435                2440                2445            
Ala Gly Pro Ala Val Ser Gln Ala Gln Glu Leu Phe Ser Ser Ser Leu
    2450                2455                2460                
Gln Pro Tyr Arg Ser Gln Pro Ala Phe Met Gln Ser Ser Leu Ser Gln
2465                2470                2475                2480
Pro Ser Val Val Leu Ser Gly Thr Ala Ile His Asn Phe Pro Thr Val
                2485                2490                2495    
Gln His Gln Glu Leu Ala Lys Ala Gln Ser Gly Leu Ala Phe Gln Gln
            2500                2505                2510        
Thr Ser Asn Thr Gln Pro Ile Pro Ile Leu Tyr Glu His Gln Leu Gly
        2515                2520                2525            
Gln Ala Ser Gly Leu Gly Gly Ser Gln Leu Ile Asp Thr His Leu Leu
    2530                2535                2540                
Gln Ala Arg Ala Asn Leu Thr Gln Ala Ser Asn Leu Tyr Ser Gly Gln
2545                2550                2555                2560
Val Gln Gln Pro Gly Gln Thr Asn Phe Tyr Asn Thr Ala Gln Ser Pro
                2565                2570                2575    
Ser Ala Leu Gln Gln Val Thr Val Pro Leu Pro Ala Ser Gln Leu Ser
            2580                2585                2590        
Leu Pro Asn Phe Gly Ser Thr Gly Gln Pro Leu Ile Ala Leu Pro Gln
        2595                2600                2605            
Thr Leu Gln Pro Pro Leu Gln His Thr Thr Pro Gln Ala Gln Ala Gln
    2610                2615                2620                
Ser Leu Ser Arg Pro Ala Gln Val Ser Gln Pro Phe Arg Gly Leu Ile
2625                2630                2635                2640
Pro Ala Gly Thr Gln His Ser Met Ile Ala Thr Thr Gly Lys Met Ser
                2645                2650                2655    
Glu Met Glu Leu Lys Ala Phe Gly Ser Gly Ile Asp Ile Lys Pro Gly
            2660                2665                2670        
Thr Pro Pro Ile Ala Gly Arg Ser Thr Thr Pro Thr Ser Ser Pro Ser
        2675                2680                2685            
Gly Leu Leu Leu Gln Val Arg Thr Ala Ser Pro Ala Lys
    2690                2695                2700    


<210> 6679
<211> 1299
<212> PRT
<213> Homo sapiens

<400> 6679
Ala Val Pro Thr Asn Gly Thr Val Asn Asn Val Ala Gln Glu Pro Val
 1               5                  10                  15      
Asn Thr Leu Gly Asp Ile Ser Gly Asn Lys Thr Pro Asp Leu Ser Asn
            20                  25                  30          
Gln Asn Ser Ser Asp Gln Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu
        35                  40                  45              
Ser Ser Asp Phe Asn Glu Arg Arg Glu Arg Asp Glu Lys Lys Asn Ala
    50                  55                  60                  
Asp Leu Asn Ala Gln Thr Val Val Lys Val Gly Glu Asn Val Leu Pro
65                  70                  75                  80  
Pro Lys Arg Glu Ile Ala Lys Arg Ser Phe Ser Ser Gln Arg Pro Val
                85                  90                  95      
Asp Arg Gln Asn Arg Arg Gly Asn Asn Gly Pro Pro Lys Ser Gly Arg
            100                 105                 110         
Asn Phe Ser Gly Pro Arg Asn Glu Arg Arg Ser Gly Pro Pro Ser Lys
        115                 120                 125             
Ser Gly Lys Arg Gly Pro Phe Asp Asp Gln Pro Ala Gly Thr Thr Gly
    130                 135                 140                 
Val Asp Leu Ile Asn Gly Ser Ser Ala His His Gln Glu Gly Val Pro
145                 150                 155                 160 
Asn Gly Thr Gly Gln Lys Asn Ser Lys Asp Ser Thr Gly Lys Lys Arg
                165                 170                 175     
Glu Asp Pro Lys Pro Gly Pro Lys Lys Pro Lys Glu Lys Val Asp Ala
            180                 185                 190         
Leu Ser Gln Phe Asp Leu Asn Asn Tyr Ala Ser Val Val Ile Ile Asp
        195                 200                 205             
Asp His Pro Glu Val Thr Val Ile Glu Asp Pro Gln Ser Asn Leu Asn
    210                 215                 220                 
Asp Asp Gly Phe Thr Glu Val Val Ser Lys Lys Gln Gln Lys Arg Leu
225                 230                 235                 240 
Gln Asp Glu Glu Arg Arg Lys Lys Glu Glu Gln Val Ile Gln Val Trp
                245                 250                 255     
Asn Lys Lys Asn Ala Asn Glu Lys Gly Arg Ser Gln Thr Ser Lys Leu
            260                 265                 270         
Pro Pro Arg Phe Ala Lys Lys Gln Ala Thr Gly Ile Gln Gln Ala Gln
        275                 280                 285             
Ser Ser Ala Ser Val Pro Pro Leu Ala Ser Ala Pro Leu Pro Pro Ser
    290                 295                 300                 
Thr Ser Ala Ser Val Pro Ala Ser Thr Ser Ala Pro Leu Pro Ala Thr
305                 310                 315                 320 
Leu Thr Pro Val Pro Ala Ser Thr Ser Ala Pro Val Pro Ala Ser Thr
                325                 330                 335     
Leu Ala Pro Val Leu Ala Ser Thr Ser Ala Pro Val Pro Ala Ser Pro
            340                 345                 350         
Leu Ala Pro Val Ser Ala Ser Ala Ser Val Ser Ala Ser Val Pro Ala
        355                 360                 365             
Ser Thr Ser Ala Ala Ala Ile Thr Ser Ser Ser Ala Pro Ala Ser Ala
    370                 375                 380                 
Pro Ala Pro Thr Pro Ile Leu Ala Ser Val Ser Thr Pro Ala Ser Val
385                 390                 395                 400 
Thr Ile Leu Ala Ser Ala Ser Ile Pro Ile Leu Ala Ser Ala Leu Ala
                405                 410                 415     
Ser Thr Ser Ala Pro Thr Pro Ala Pro Ala Ala Ser Ser Pro Ala Ala
            420                 425                 430         
Pro Val Ile Thr Ala Pro Thr Ile Pro Ala Ser Ala Pro Thr Ala Ser
        435                 440                 445             
Val Pro Leu Ala Pro Ala Ser Ala Ser Ala Pro Ala Pro Ala Pro Thr
    450                 455                 460                 
Pro Val Ser Ala Pro Asn Pro Ala Pro Pro Ala Pro Ala Gln Thr Gln
465                 470                 475                 480 
Ala Gln Thr His Lys Pro Ala Gln Asn Pro Leu Gln Thr Thr Ser Gln
                485                 490                 495     
Ser Ser Lys Gln Pro Pro Pro Ser Ile Arg Leu Pro Ser Ala Gln Thr
            500                 505                 510         
Pro Asn Gly Thr Asp Tyr Val Ala Ser Gly Lys Ser Ile Gln Thr Pro
        515                 520                 525             
Gln Ser His Gly Thr Leu Thr Ala Glu Leu Trp Asp Asn Lys Val Ala
    530                 535                 540                 
Pro Pro Ala Val Leu Asn Asp Ile Ser Lys Lys Leu Gly Pro Ile Ser
545                 550                 555                 560 
Pro Pro Gln Pro Pro Ser Val Ser Ala Trp Asn Lys Pro Leu Thr Ser
                565                 570                 575     
Phe Gly Ser Ala Pro Ser Ser Glu Gly Ala Lys Asn Gly Gln Glu Ser
            580                 585                 590         
Gly Leu Glu Ile Gly Thr Asp Thr Ile Gln Phe Gly Ala Pro Ala Ser
        595                 600                 605             
Asn Gly Asn Glu Asn Glu Val Val Pro Val Leu Ser Glu Lys Ser Ala
    610                 615                 620                 
Asp Lys Ile Pro Glu Pro Lys Glu Gln Arg Gln Lys Gln Pro Arg Ala
625                 630                 635                 640 
Gly Pro Ile Lys Ala Gln Lys Leu Pro Asp Leu Ser Pro Val Glu Asn
                645                 650                 655     
Lys Glu His Lys Pro Gly Pro Ile Gly Lys Glu Arg Ser Leu Lys Asn
            660                 665                 670         
Arg Lys Val Lys Asp Ala Gln Gln Val Glu Pro Glu Gly Gln Glu Lys
        675                 680                 685             
Pro Ser Pro Ala Thr Val Arg Ser Thr Asp Pro Val Thr Thr Lys Glu
    690                 695                 700                 
Thr Lys Ala Val Ser Glu Met Ser Thr Glu Ile Gly Thr Met Ile Ser
705                 710                 715                 720 
Val Ser Ser Ala Glu Tyr Gly Thr Asn Ala Lys Met Glu Ser Ala Arg
                725                 730                 735     
Lys Ala Trp Glu Asn Ser Pro Asn Val Arg Glu Lys Gly Ser Pro Val
            740                 745                 750         
Thr Ser Thr Ala Pro Pro Ile Ala Thr Gly Val Ser Ser Ser Ala Ser
        755                 760                 765             
Gly Pro Ser Thr Ala Asn Tyr Asn Ser Phe Ser Ser Ala Ser Met Pro
    770                 775                 780                 
Gln Ile Pro Val Ala Ser Val Thr Pro Thr Ala Ser Leu Ser Gly Ala
785                 790                 795                 800 
Gly Thr Tyr Thr Thr Ser Ser Leu Ser Thr Lys Ser Thr Thr Thr Ser
                805                 810                 815     
Asp Pro Pro Asn Ile Cys Lys Val Lys Pro Gln Gln Leu Gln Thr Ser
            820                 825                 830         
Ser Leu Pro Ser Ala Ser His Phe Ser Gln Leu Ser Cys Met Pro Ser
        835                 840                 845             
Leu Ile Ala Gln Gln Gln Gln Asn Pro Gln Val Tyr Val Ser Gln Ser
    850                 855                 860                 
Ala Ala Ala Gln Ile Pro Ala Phe Tyr Met Asp Thr Ser His Leu Phe
865                 870                 875                 880 
Asn Thr Gln His Ala Arg Leu Ala Pro Pro Ser Leu Ala Gln Gln Gln
                885                 890                 895     
Gly Phe Gln Pro Gly Leu Ser Gln Pro Thr Ser Val Gln Gln Ile Pro
            900                 905                 910         
Ile Pro Ile Tyr Ala Pro Leu Gln Gly Gln His Gln Ala Gln Leu Ser
        915                 920                 925             
Leu Gly Ala Gly Pro Ala Val Ser Gln Ala Gln Glu Leu Phe Ser Ser
    930                 935                 940                 
Ser Leu Gln Pro Tyr Arg Ser Gln Pro Ala Phe Met Gln Ser Ser Leu
945                 950                 955                 960 
Ser Gln Pro Ser Val Val Leu Ser Gly Thr Ala Ile His Asn Phe Pro
                965                 970                 975     
Thr Val Gln His Gln Glu Leu Ala Lys Ala Gln Ser Gly Leu Ala Phe
            980                 985                 990         
Gln Gln Thr Ser Asn Thr Gln Pro Ile Pro Ile Leu Tyr Glu His Gln
        995                 1000                1005            
Leu Gly Gln Ala Ser Gly Leu Gly Gly Ser Gln Leu Ile Asp Thr His
    1010                1015                1020                
Leu Leu Gln Ala Arg Ala Asn Leu Thr Gln Ala Ser Asn Leu Tyr Ser
1025                1030                1035                1040
Gly Gln Val Gln Gln Pro Gly Gln Thr Asn Phe Tyr Asn Thr Ala Gln
                1045                1050                1055    
Ser Pro Ser Ala Leu Gln Gln Val Thr Val Pro Leu Pro Ala Ser Gln
            1060                1065                1070        
Leu Ser Leu Pro Asn Phe Gly Ser Thr Gly Gln Pro Leu Ile Ala Leu
        1075                1080                1085            
Pro Gln Thr Leu Gln Pro Pro Leu Gln His Thr Thr Pro Gln Ala Gln
    1090                1095                1100                
Ala Gln Ser Leu Ser Arg Pro Ala Gln Val Ser Gln Pro Phe Arg Gly
1105                1110                1115                1120
Leu Ile Pro Ala Gly Thr Gln His Ser Met Ile Ala Thr Thr Gly Lys
                1125                1130                1135    
Met Ser Glu Met Glu Leu Lys Ala Phe Gly Ser Gly Ile Asp Ile Lys
            1140                1145                1150        
Pro Gly Thr Pro Pro Ile Ala Gly Arg Ser Thr Thr Pro Thr Ser Ser
        1155                1160                1165            
Pro Phe Arg Ala Thr Ser Thr Ser Pro Asn Ser Gln Ser Ser Lys Met
    1170                1175                1180                
Asn Ser Ile Val Tyr Gln Lys Gln Phe Gln Ser Ala Pro Ala Thr Val
1185                1190                1195                1200
Arg Met Thr Gln Pro Phe Pro Thr Gln Phe Ala Pro Gln Ala Lys Gln
                1205                1210                1215    
Arg Ala Glu Val Leu Gln Ser Thr Gln Arg Phe Phe Ser Glu Gln Gln
            1220                1225                1230        
Gln Ser Lys Gln Ile Gly Gly Gly Lys Ala Gln Lys Val Asp Ser Asp
        1235                1240                1245            
Ser Ser Lys Pro Pro Glu Thr Leu Thr Asp Pro Pro Gly Val Cys Gln
    1250                1255                1260                
Glu Lys Val Glu Glu Lys Pro Pro Pro Ala Pro Ser Ile Ala Thr Lys
1265                1270                1275                1280
Pro Val Arg Thr Gly Pro Ile Lys Pro Gln Ala Ile Lys Thr Glu Glu
                1285                1290                1295    
Thr Lys Ser
            


<210> 6680
<211> 183
<212> PRT
<213> Homo sapiens

<400> 6680
Met Leu Tyr Lys Ser Ser Asp Arg Pro Ala His Lys Val Ser Met Leu
 1               5                  10                  15      
Leu Leu Cys His Ala Leu Ala Ile Ala Val Val Gln Ile Val Ile Phe
            20                  25                  30          
Ser Glu Ser Trp Ala Phe Ala Lys Asn Ile Asn Phe Tyr Asn Val Arg
        35                  40                  45              
Pro Pro Leu Asp Pro Thr Pro Phe Pro Asn Ser Phe Lys Cys Phe Thr
    50                  55                  60                  
Cys Glu Asn Ala Gly Asp Asn Tyr Asn Cys Asn Arg Trp Ala Glu Asp
65                  70                  75                  80  
Lys Trp Cys Pro Gln Asn Thr Gln Tyr Cys Leu Thr Val His His Phe
                85                  90                  95      
Thr Ser His Gly Arg Ser Thr Ser Ile Thr Lys Lys Cys Ala Ser Arg
            100                 105                 110         
Ser Glu Cys His Phe Val Gly Cys His His Ser Arg Asp Ser Glu His
        115                 120                 125             
Thr Glu Cys Arg Ser Cys Cys Glu Gly Met Ile Cys Asn Val Glu Leu
    130                 135                 140                 
Pro Thr Asn His Thr Asn Ala Val Phe Ala Val Met His Ala Gln Arg
145                 150                 155                 160 
Thr Ser Gly Ser Ser Ala Pro Thr Leu Tyr Leu Pro Val Leu Ala Trp
                165                 170                 175     
Val Phe Val Leu Pro Leu Leu
            180             


<210> 6681
<211> 342
<212> PRT
<213> Homo sapiens

<400> 6681
Ala Asp Phe Leu Ser Arg Ala Gly Trp Val Gly Thr Gly Ser Leu Pro
 1               5                  10                  15      
Pro Pro Gln Arg Trp Pro Leu Pro His Cys Arg Pro Pro Gly Pro Pro
            20                  25                  30          
Phe Asn Leu Val Val Glu Pro Cys Gly Phe Pro Ala Glu Pro Gly Pro
        35                  40                  45              
Gly Leu Leu Pro Arg Gly Arg Gly Ser Pro Val Pro Ala Arg Pro Pro
    50                  55                  60                  
Pro Ala Pro Gln Val Val Gln Gly Gly Glu Glu Pro Arg Pro Ala Pro
65                  70                  75                  80  
Arg Gly Ser Ser Gln Arg Arg Pro Gln Ala Gly Ala Leu Gly Ala Trp
                85                  90                  95      
Ala Gly Ser Arg Val Arg Ala Pro Arg Gly Ser Val Gly Ala Gly Gly
            100                 105                 110         
Glu Ile Cys His Thr Ser Ala Cys Cys Trp Gln Pro Ser Trp Thr Arg
        115                 120                 125             
Leu Leu Leu Leu Ile Thr Trp Met Leu Leu Ile Thr Leu Ser Ala Asn
    130                 135                 140                 
Leu Phe Thr Val Pro Glu Arg Ser Leu Thr Thr Thr Phe Ser Phe Ser
145                 150                 155                 160 
Arg Tyr Lys Ser Ser Asp Arg Pro Ala His Lys Val Ser Met Leu Leu
                165                 170                 175     
Leu Cys His Ala Leu Ala Ile Ala Val Val Gln Ile Val Ile Phe Ser
            180                 185                 190         
Glu Ser Trp Ala Phe Ala Lys Asn Ile Asn Phe Tyr Asn Val Arg Pro
        195                 200                 205             
Pro Leu Asp Pro Thr Pro Phe Pro Asn Ser Phe Lys Cys Phe Thr Cys
    210                 215                 220                 
Glu Asn Ala Gly Asp Asn Tyr Asn Cys Asn Arg Trp Ala Glu Asp Lys
225                 230                 235                 240 
Trp Cys Pro Gln Asn Thr Gln Tyr Cys Leu Thr Val His His Phe Thr
                245                 250                 255     
Ser His Gly Arg Ser Thr Ser Ile Thr Lys Lys Cys Ala Ser Arg Ser
            260                 265                 270         
Glu Cys His Phe Val Gly Cys His His Ser Arg Asp Ser Glu His Thr
        275                 280                 285             
Glu Cys Arg Ser Cys Cys Glu Gly Met Ile Cys Asn Val Glu Leu Pro
    290                 295                 300                 
Thr Asn His Thr Asn Ala Val Phe Ala Val Met His Ala Gln Arg Thr
305                 310                 315                 320 
Ser Gly Ser Ser Ala Pro Thr Leu Tyr Leu Pro Val Leu Ala Trp Val
                325                 330                 335     
Phe Val Leu Pro Leu Leu
            340         


<210> 6682
<211> 303
<212> PRT
<213> Homo sapiens

<400> 6682
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu
 1               5                  10                  15      
Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser
            20                  25                  30          
His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp
        35                  40                  45              
Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr
    50                  55                  60                  
Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp
65                  70                  75                  80  
Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln
                85                  90                  95      
Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile
            100                 105                 110         
Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr
        115                 120                 125             
Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys
    130                 135                 140                 
Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp
145                 150                 155                 160 
Lys Thr Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu
                165                 170                 175     
Val Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe
            180                 185                 190         
Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg Gly
        195                 200                 205             
Gly Phe Gly Gly Ser His Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp
    210                 215                 220                 
Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly Gly
225                 230                 235                 240 
Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly
                245                 250                 255     
Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly
            260                 265                 270         
Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Val Ala Met Ala
        275                 280                 285             
Val Pro Ala Ala Ala Val Ala Met Ala Val Ala Glu Asp Phe Asn
    290                 295                 300             


<210> 6683
<211> 320
<212> PRT
<213> Homo sapiens

<400> 6683
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu
 1               5                  10                  15      
Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser
            20                  25                  30          
His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp
        35                  40                  45              
Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr
    50                  55                  60                  
Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp
65                  70                  75                  80  
Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln
                85                  90                  95      
Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile
            100                 105                 110         
Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr
        115                 120                 125             
Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys
    130                 135                 140                 
Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp
145                 150                 155                 160 
Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu
                165                 170                 175     
Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser
            180                 185                 190         
Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly
        195                 200                 205             
Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly
    210                 215                 220                 
Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser
225                 230                 235                 240 
Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly
                245                 250                 255     
Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn
            260                 265                 270         
Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro
        275                 280                 285             
Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly
    290                 295                 300                 
Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe
305                 310                 315                 320 


<210> 6684
<211> 372
<212> PRT
<213> Homo sapiens

<400> 6684
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu
 1               5                  10                  15      
Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser
            20                  25                  30          
His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp
        35                  40                  45              
Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr
    50                  55                  60                  
Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp
65                  70                  75                  80  
Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln
                85                  90                  95      
Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile
            100                 105                 110         
Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr
        115                 120                 125             
Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys
    130                 135                 140                 
Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp
145                 150                 155                 160 
Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu
                165                 170                 175     
Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser
            180                 185                 190         
Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly
        195                 200                 205             
Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly
    210                 215                 220                 
Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser
225                 230                 235                 240 
Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly
                245                 250                 255     
Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln
            260                 265                 270         
Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp
        275                 280                 285             
Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser
    290                 295                 300                 
Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn
305                 310                 315                 320 
Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg
                325                 330                 335     
Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg
            340                 345                 350         
Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser
        355                 360                 365             
Gly Arg Arg Phe
    370         


<210> 6685
<211> 1197
<212> PRT
<213> Homo sapiens

<400> 6685
Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln
 1               5                  10                  15      
Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly
            20                  25                  30          
Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu
        35                  40                  45              
Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp
    50                  55                  60                  
Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser
65                  70                  75                  80  
Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu
                85                  90                  95      
Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg
            100                 105                 110         
Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln
        115                 120                 125             
Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu
    130                 135                 140                 
Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu
145                 150                 155                 160 
Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr
                165                 170                 175     
Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu
            180                 185                 190         
Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln
        195                 200                 205             
Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met
    210                 215                 220                 
Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu
225                 230                 235                 240 
Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met
                245                 250                 255     
Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys
            260                 265                 270         
Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys
        275                 280                 285             
Asp Lys Glu Thr Gly Val Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala
    290                 295                 300                 
Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys
305                 310                 315                 320 
Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys
                325                 330                 335     
Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Val
            340                 345                 350         
Lys Lys Ile Thr Asp Gly Leu His Ala Leu Gln Glu Ala Ser Asn Lys
        355                 360                 365             
Asp Ala Glu Ala Leu Ala Ala Ala Gln Gln His Phe Asn Ala Val Ser
    370                 375                 380                 
Ala Gly Leu Ser Ser Asn Glu Asp Gly Ala Glu Ala Thr Leu Ala Gly
385                 390                 395                 400 
Gln Met Met Ala Cys Lys Asn Asp Ile Ser Lys Ala Gln Thr Glu Ala
                405                 410                 415     
Lys Gln Ala Gln Met Lys Leu Lys His Ala Gln Gln Glu Leu Lys Asn
            420                 425                 430         
Lys Gln Ala Glu Val Lys Lys Met Asp Ser Gly Tyr Arg Lys Asp Gln
        435                 440                 445             
Glu Ala Leu Glu Ala Val Lys Arg Leu Lys Glu Lys Leu Glu Ala Glu
    450                 455                 460                 
Met Lys Lys Leu Asn Tyr Glu Glu Asn Lys Glu Glu Ser Leu Leu Glu
465                 470                 475                 480 
Lys Arg Arg Gln Leu Ser Arg Asp Ile Gly Arg Leu Lys Glu Thr Tyr
                485                 490                 495     
Glu Ala Leu Leu Ala Arg Phe Pro Asn Leu Arg Phe Ala Tyr Lys Asp
            500                 505                 510         
Pro Glu Lys Asn Trp Asn Arg Asn Cys Val Lys Gly Leu Val Ala Ser
        515                 520                 525             
Leu Ile Ser Val Lys Asp Thr Ser Ala Thr Thr Ala Leu Glu Leu Val
    530                 535                 540                 
Ala Gly Glu Arg Leu Tyr Asn Val Val Val Asp Thr Glu Val Thr Gly
545                 550                 555                 560 
Lys Lys Leu Leu Glu Arg Gly Glu Leu Lys Arg Arg Tyr Thr Ile Ile
                565                 570                 575     
Pro Leu Asn Lys Ile Ser Ala Arg Cys Ile Ala Pro Glu Thr Leu Arg
            580                 585                 590         
Val Ala Gln Asn Leu Val Gly Pro Asp Asn Val His Val Ala Leu Ser
        595                 600                 605             
Leu Val Glu Tyr Lys Pro Glu Leu Gln Lys Ala Met Glu Phe Val Phe
    610                 615                 620                 
Gly Thr Thr Phe Val Cys Asp Asn Met Asp Asn Ala Lys Lys Val Ala
625                 630                 635                 640 
Phe Asp Lys Arg Ile Met Thr Arg Thr Val Thr Leu Gly Gly Asp Val
                645                 650                 655     
Phe Asp Pro His Gly Thr Leu Ser Gly Gly Ala Arg Ser Gln Ala Ala
            660                 665                 670         
Ser Ile Leu Thr Lys Phe Gln Glu Leu Lys Asp Val Gln Asp Glu Leu
        675                 680                 685             
Arg Ile Lys Glu Asn Glu Leu Arg Ala Leu Glu Glu Glu Leu Ala Gly
    690                 695                 700                 
Leu Lys Asn Thr Ala Glu Lys Tyr Arg Gln Leu Lys Gln Gln Trp Glu
705                 710                 715                 720 
Met Lys Thr Glu Glu Ala Asp Leu Leu Gln Thr Lys Leu Gln Gln Ser
                725                 730                 735     
Ser Tyr His Lys Gln Gln Glu Glu Leu Asp Ala Leu Lys Lys Thr Ile
            740                 745                 750         
Glu Glu Ser Glu Glu Thr Leu Lys Asn Thr Lys Glu Ile Gln Arg Lys
        755                 760                 765             
Ala Glu Glu Lys Tyr Glu Val Leu Glu Asn Lys Met Lys Asn Ala Glu
    770                 775                 780                 
Ala Glu Arg Glu Arg Glu Leu Lys Asp Ala Gln Lys Lys Leu Asp Cys
785                 790                 795                 800 
Ala Lys Thr Lys Ala Asp Ala Ser Ser Lys Lys Met Lys Glu Lys Gln
                805                 810                 815     
Gln Glu Val Glu Ala Ile Thr Leu Glu Leu Glu Glu Leu Lys Arg Glu
            820                 825                 830         
His Thr Ser Tyr Lys Gln Gln Leu Glu Ala Val Asn Glu Ala Ile Lys
        835                 840                 845             
Ser Tyr Glu Ser Gln Ile Glu Val Met Ala Ala Glu Val Ala Lys Asn
    850                 855                 860                 
Lys Glu Ser Val Asn Lys Ala Gln Glu Glu Val Thr Lys Gln Lys Glu
865                 870                 875                 880 
Val Ile Thr Ala Gln Asp Thr Val Ile Lys Leu Asn Met Gln Lys Trp
                885                 890                 895     
Gln Asn Thr Arg Ser Lys Thr Met Ile Leu Ser Leu Lys Ile Lys Glu
            900                 905                 910         
Leu Asp His His Ile Ser Lys His Lys Arg Glu Ala Glu Asp Gly Ala
        915                 920                 925             
Ala Lys Val Ser Lys Met Leu Lys Asp Tyr Asp Trp Ile Asn Ala Glu
    930                 935                 940                 
Arg His Leu Phe Gly Gln Pro Asn Ser Ala Tyr Asp Phe Lys Thr Asn
945                 950                 955                 960 
Asn Pro Lys Glu Ala Gly Gln Arg Leu Gln Lys Leu Gln Glu Met Lys
                965                 970                 975     
Glu Lys Leu Gly Arg Asn Val Asn Met Arg Ala Met Asn Val Leu Thr
            980                 985                 990         
Glu Ala Glu Glu Arg Cys Asn Asp Leu Met Lys Lys Lys Arg Ile Val
        995                 1000                1005            
Glu Asn Asp Lys Ser Lys Ile Leu Thr Thr Ile Glu Asp Leu Asp Gln
    1010                1015                1020                
Lys Lys Asn Gln Ala Leu Asn Ile Ala Trp Gln Lys Val Asn Lys Asp
1025                1030                1035                1040
Phe Gly Ser Ile Phe Ser Thr Leu Leu Pro Gly Ala Asn Ala Met Leu
                1045                1050                1055    
Ala Pro Pro Glu Gly Gln Thr Val Leu Asp Gly Leu Glu Phe Lys Val
            1060                1065                1070        
Ala Leu Gly Asn Thr Trp Lys Glu Asn Leu Thr Glu Leu Ser Gly Gly
        1075                1080                1085            
Gln Arg Ser Leu Val Ala Leu Ser Leu Ile Leu Ser Met Leu Leu Phe
    1090                1095                1100                
Lys Pro Ala Pro Ile Tyr Ile Leu Asp Glu Val Asp Ala Ala Leu Asp
1105                1110                1115                1120
Leu Ser His Thr Gln Asn Ile Gly Gln Met Leu Arg Thr His Phe Thr
                1125                1130                1135    
His Ser Gln Phe Ile Val Val Ser Leu Lys Glu Gly Met Phe Asn Asn
            1140                1145                1150        
Ala Asn Val Leu Phe Lys Thr Lys Phe Val Asp Gly Val Ser Thr Val
        1155                1160                1165            
Ala Arg Phe Thr Gln Cys Gln Asn Gly Lys Ile Ser Lys Glu Ala Lys
    1170                1175                1180                
Ser Lys Ala Lys Pro Pro Lys Gly Ala His Val Glu Val
1185                1190                1195        


<210> 6686
<211> 1099
<212> PRT
<213> Homo sapiens

<400> 6686
Met His Ile Lys Ser Ile Ile Leu Glu Gly Phe Lys Ser Tyr Ala Gln
 1               5                  10                  15      
Arg Thr Glu Val Asn Gly Phe Asp Pro Leu Phe Asn Ala Ile Thr Gly
            20                  25                  30          
Leu Asn Gly Ser Gly Lys Ser Asn Ile Leu Asp Ser Ile Cys Phe Leu
        35                  40                  45              
Leu Gly Ile Ser Asn Leu Ser Gln Val Arg Ala Ser Asn Leu Gln Asp
    50                  55                  60                  
Leu Val Tyr Lys Asn Gly Gln Ala Gly Ile Thr Lys Ala Ser Val Ser
65                  70                  75                  80  
Ile Thr Phe Asp Asn Ser Asp Lys Lys Gln Ser Pro Leu Gly Phe Glu
                85                  90                  95      
Val His Asp Glu Ile Thr Val Thr Arg Gln Val Val Ile Gly Gly Arg
            100                 105                 110         
Asn Lys Tyr Leu Ile Asn Gly Val Asn Ala Asn Asn Thr Arg Val Gln
        115                 120                 125             
Asp Leu Phe Cys Ser Val Gly Leu Asn Val Asn Asn Pro His Phe Leu
    130                 135                 140                 
Ile Met Gln Gly Arg Ile Thr Lys Val Leu Asn Met Lys Pro Pro Glu
145                 150                 155                 160 
Ile Leu Ser Met Ile Glu Glu Ala Ala Gly Thr Arg Met Tyr Glu Tyr
                165                 170                 175     
Lys Lys Ile Ala Ala Gln Lys Thr Ile Glu Lys Lys Glu Ala Lys Leu
            180                 185                 190         
Lys Glu Ile Lys Thr Ile Leu Glu Glu Glu Ile Thr Pro Thr Ile Gln
        195                 200                 205             
Lys Leu Lys Glu Glu Arg Ser Ser Tyr Leu Glu Tyr Gln Lys Val Met
    210                 215                 220                 
Arg Glu Ile Glu His Leu Ser Arg Leu Tyr Ile Ala Tyr Gln Phe Leu
225                 230                 235                 240 
Leu Ala Glu Asp Thr Lys Val Arg Ser Ala Glu Glu Leu Lys Glu Met
                245                 250                 255     
Gln Asp Lys Val Ile Lys Leu Gln Glu Glu Leu Ser Glu Asn Asp Lys
            260                 265                 270         
Lys Ile Lys Ala Leu Asn His Glu Ile Glu Glu Leu Glu Lys Arg Lys
        275                 280                 285             
Asp Lys Glu Thr Gly Val Ile Leu Arg Ser Leu Glu Asp Ala Leu Ala
    290                 295                 300                 
Glu Ala Gln Arg Val Asn Thr Lys Ser Gln Ser Ala Phe Asp Leu Lys
305                 310                 315                 320 
Lys Lys Asn Leu Ala Cys Glu Glu Ser Lys Arg Lys Glu Leu Glu Lys
                325                 330                 335     
Asn Met Val Glu Asp Ser Lys Thr Leu Ala Ala Lys Glu Lys Glu Val
            340                 345                 350         
Lys Lys Ile Thr Asp Gly Leu His Ala Leu Gln Glu Ala Ser Asn Lys
        355                 360                 365             
Asp Ala Glu Ala Leu Ala Ala Ala Gln Gln His Phe Asn Ala Val Ser
    370                 375                 380                 
Ala Gly Leu Ser Ser Asn Glu Asp Gly Ala Glu Ala Thr Leu Ala Gly
385                 390                 395                 400 
Gln Met Met Ala Cys Lys Asn Asp Ile Ser Lys Ala Gln Thr Glu Ala
                405                 410                 415     
Lys Gln Ala Gln Met Lys Leu Lys His Ala Gln Gln Glu Leu Lys Asn
            420                 425                 430         
Lys Gln Ala Glu Val Lys Lys Met Asp Ser Gly Tyr Arg Lys Asp Gln
        435                 440                 445             
Glu Ala Leu Glu Ala Val Lys Arg Leu Lys Glu Lys Leu Glu Ala Glu
    450                 455                 460                 
Met Lys Lys Leu Asn Tyr Glu Glu Asn Lys Glu Glu Ser Leu Leu Glu
465                 470                 475                 480 
Lys Arg Arg Gln Leu Ser Arg Asp Ile Gly Arg Leu Lys Glu Thr Tyr
                485                 490                 495     
Glu Ala Leu Leu Ala Arg Phe Pro Asn Leu Arg Phe Ala Tyr Lys Asp
            500                 505                 510         
Pro Glu Lys Asn Trp Asn Arg Asn Cys Val Lys Gly Leu Val Ala Ser
        515                 520                 525             
Leu Ile Ser Val Lys Asp Thr Ser Ala Thr Thr Ala Leu Glu Leu Val
    530                 535                 540                 
Ala Gly Glu Arg Leu Tyr Asn Val Val Val Asp Thr Glu Val Thr Gly
545                 550                 555                 560 
Lys Lys Leu Leu Glu Arg Gly Glu Leu Lys Arg Arg Tyr Thr Ile Ile
                565                 570                 575     
Pro Leu Asn Lys Ile Ser Ala Arg Cys Ile Ala Pro Glu Thr Leu Arg
            580                 585                 590         
Val Ala Gln Asn Leu Val Gly Pro Asp Asn Val His Val Ala Leu Ser
        595                 600                 605             
Leu Val Glu Tyr Lys Pro Glu Leu Gln Lys Ala Met Glu Phe Val Phe
    610                 615                 620                 
Gly Thr Thr Phe Val Cys Asp Asn Met Asp Asn Ala Lys Lys Val Ala
625                 630                 635                 640 
Phe Asp Lys Arg Ile Met Thr Arg Thr Val Thr Leu Gly Gly Asp Val
                645                 650                 655     
Phe Asp Pro His Gly Thr Leu Ser Gly Gly Ala Arg Ser Gln Ala Ala
            660                 665                 670         
Ser Ile Leu Thr Lys Phe Gln Glu Leu Lys Asp Val Gln Asp Glu Leu
        675                 680                 685             
Arg Ile Lys Glu Asn Glu Leu Arg Ala Leu Glu Glu Glu Leu Ala Gly
    690                 695                 700                 
Leu Lys Asn Thr Ala Glu Lys Tyr Arg Gln Leu Lys Gln Gln Trp Glu
705                 710                 715                 720 
Met Lys Thr Glu Glu Ala Asp Leu Leu Gln Thr Lys Leu Gln Gln Ser
                725                 730                 735     
Ser Tyr His Lys Gln Gln Glu Glu Leu Asp Ala Leu Lys Lys Thr Ile
            740                 745                 750         
Glu Glu Ser Glu Glu Thr Leu Lys Asn Thr Lys Glu Ile Gln Arg Lys
        755                 760                 765             
Ala Glu Glu Lys Tyr Glu Val Leu Glu Asn Lys Met Lys Asn Ala Glu
    770                 775                 780                 
Ala Glu Arg Glu Arg Glu Leu Lys Asp Ala Gln Lys Lys Leu Asp Cys
785                 790                 795                 800 
Ala Lys Thr Lys Ala Asp Ala Ser Ser Lys Lys Met Lys Glu Lys Gln
                805                 810                 815     
Gln Glu Val Glu Ala Ile Thr Leu Glu Leu Glu Glu Leu Lys Arg Glu
            820                 825                 830         
His Thr Ser Tyr Lys Gln Gln Leu Glu Ala Val Asn Glu Ala Ile Lys
        835                 840                 845             
Ser Tyr Glu Ser Gln Ile Glu Val Met Ala Ala Glu Val Ala Lys Asn
    850                 855                 860                 
Lys Glu Ser Val Asn Lys Ala Gln Glu Glu Val Thr Lys Gln Lys Glu
865                 870                 875                 880 
Val Ile Thr Ala Gln Asp Thr Val Ile Lys Leu Asn Met Gln Lys Trp
                885                 890                 895     
Gln Asn Thr Arg Ser Lys Thr Met Ile Leu Ser Leu Lys Ile Lys Glu
            900                 905                 910         
Leu Asp His His Ile Ser Lys His Lys Arg Glu Ala Glu Asp Gly Ala
        915                 920                 925             
Ala Lys Val Ser Lys Met Leu Lys Asp Tyr Asp Trp Ile Asn Ala Glu
    930                 935                 940                 
Arg His Leu Phe Gly Gln Pro Asn Ser Ala Tyr Asp Phe Lys Thr Asn
945                 950                 955                 960 
Asn Pro Lys Glu Ala Gly Gln Arg Leu Gln Lys Leu Gln Glu Met Lys
                965                 970                 975     
Glu Lys Leu Gly Arg Asn Val Asn Met Arg Ala Met Asn Val Leu Thr
            980                 985                 990         
Glu Ala Glu Glu Arg Cys Asn Asp Leu Met Lys Lys Lys Arg Ile Val
        995                 1000                1005            
Glu Asn Asp Lys Ser Lys Ile Leu Thr Thr Ile Glu Asp Leu Asp Gln
    1010                1015                1020                
Lys Lys Asn Gln Ala Leu Asn Ile Ala Trp Gln Lys Val Asn Lys Asp
1025                1030                1035                1040
Phe Gly Ser Ile Phe Ser Thr Leu Leu Pro Gly Ala Asn Ala Met Leu
                1045                1050                1055    
Ala Pro Pro Glu Gly Gln Thr Val Leu Asp Gly Leu Glu Phe Lys Val
            1060                1065                1070        
Ala Leu Gly Asn Thr Trp Lys Glu Asn Leu Thr Glu Leu Ser Gly Gly
        1075                1080                1085            
Gln Arg Gln Lys Gln Gln Asn His Thr Thr Gly
    1090                1095                


<210> 6687
<211> 1412
<212> PRT
<213> Homo sapiens

<400> 6687
Met Thr Thr Lys Arg Ser Leu Phe Val Arg Leu Val Pro Cys Arg Cys
 1               5                  10                  15      
Leu Arg Gly Glu Glu Glu Thr Val Thr Thr Leu Asp Tyr Ser His Cys
            20                  25                  30          
Ser Leu Glu Gln Val Pro Lys Glu Ile Phe Thr Phe Glu Lys Thr Leu
        35                  40                  45              
Glu Glu Leu Tyr Leu Asp Ala Asn Gln Ile Glu Glu Leu Pro Lys Gln
    50                  55                  60                  
Leu Phe Asn Cys Gln Ser Leu His Lys Leu Ser Leu Pro Asp Asn Asp
65                  70                  75                  80  
Leu Thr Thr Leu Pro Ala Ser Ile Ala Asn Leu Ile Asn Leu Arg Glu
                85                  90                  95      
Leu Asp Val Ser Lys Asn Gly Ile Gln Glu Phe Pro Glu Asn Ile Lys
            100                 105                 110         
Asn Cys Lys Val Leu Thr Ile Val Glu Ala Ser Val Asn Pro Ile Ser
        115                 120                 125             
Lys Leu Pro Asp Gly Phe Ser Gln Leu Leu Asn Leu Thr Gln Leu Tyr
    130                 135                 140                 
Leu Asn Asp Ala Phe Leu Glu Phe Leu Pro Ala Asn Phe Gly Arg Leu
145                 150                 155                 160 
Thr Lys Leu Gln Ile Leu Glu Leu Arg Glu Asn Gln Leu Lys Met Leu
                165                 170                 175     
Pro Lys Thr Met Asn Arg Leu Thr Gln Leu Glu Arg Leu Asp Leu Gly
            180                 185                 190         
Ser Asn Glu Phe Thr Glu Val Pro Glu Val Leu Glu Gln Leu Ser Gly
        195                 200                 205             
Leu Lys Glu Phe Trp Met Asp Ala Asn Arg Leu Thr Phe Ile Pro Gly
    210                 215                 220                 
Phe Ile Gly Ser Leu Lys Gln Leu Thr Tyr Leu Asp Val Ser Lys Asn
225                 230                 235                 240 
Asn Ile Glu Met Val Glu Glu Gly Ile Ser Thr Cys Glu Asn Leu Gln
                245                 250                 255     
Asp Leu Leu Leu Ser Ser Asn Ser Leu Gln Gln Leu Pro Glu Thr Ile
            260                 265                 270         
Gly Ser Leu Lys Asn Ile Thr Thr Leu Lys Ile Asp Glu Asn Gln Leu
        275                 280                 285             
Met Tyr Leu Pro Asp Ser Ile Gly Gly Leu Ile Ser Val Glu Glu Leu
    290                 295                 300                 
Asp Cys Ser Phe Asn Glu Val Glu Ala Leu Pro Ser Ser Ile Gly Gln
305                 310                 315                 320 
Leu Thr Asn Leu Arg Thr Phe Ala Ala Asp His Asn Tyr Leu Gln Gln
                325                 330                 335     
Leu Pro Pro Glu Ile Gly Ser Trp Lys Asn Ile Thr Val Leu Phe Leu
            340                 345                 350         
His Ser Asn Lys Leu Glu Thr Leu Pro Glu Glu Met Gly Asp Met Gln
        355                 360                 365             
Lys Leu Lys Val Ile Asn Leu Ser Asp Asn Arg Leu Lys Asn Leu Pro
    370                 375                 380                 
Phe Ser Phe Thr Lys Leu Gln Gln Leu Thr Ala Met Trp Leu Ser Asp
385                 390                 395                 400 
Asn Gln Ser Lys Pro Leu Ile Pro Leu Gln Lys Glu Thr Asp Ser Glu
                405                 410                 415     
Thr Gln Lys Met Val Leu Thr Asn Tyr Met Phe Pro Gln Gln Pro Arg
            420                 425                 430         
Thr Glu Asp Val Met Phe Ile Ser Asp Asn Glu Ser Phe Asn Pro Ser
        435                 440                 445             
Leu Trp Glu Glu Gln Arg Lys Gln Arg Ala Gln Val Ala Phe Glu Cys
    450                 455                 460                 
Asp Glu Asp Lys Asp Glu Arg Glu Ala Pro Pro Arg Glu Gly Asn Leu
465                 470                 475                 480 
Lys Arg Tyr Pro Thr Pro Tyr Pro Asp Glu Leu Lys Asn Met Val Lys
                485                 490                 495     
Thr Val Gln Thr Ile Val His Arg Leu Lys Asp Glu Glu Thr Asn Glu
            500                 505                 510         
Asp Ser Gly Arg Asp Leu Lys Pro His Glu Asp Gln Gln Asp Ile Asn
        515                 520                 525             
Lys Asp Val Gly Val Lys Thr Ser Glu Ser Thr Thr Thr Val Lys Ser
    530                 535                 540                 
Lys Val Asp Glu Arg Glu Lys Tyr Met Ile Gly Asn Ser Val Gln Lys
545                 550                 555                 560 
Ile Ser Glu Pro Glu Ala Glu Ile Ser Pro Gly Ser Leu Pro Val Thr
                565                 570                 575     
Ala Asn Met Lys Ala Ser Glu Asn Leu Lys His Ile Val Asn His Asp
            580                 585                 590         
Asp Val Phe Glu Glu Ser Glu Glu Leu Ser Ser Asp Glu Glu Met Lys
        595                 600                 605             
Met Ala Glu Met Arg Pro Pro Leu Ile Glu Thr Ser Ile Asn Gln Pro
    610                 615                 620                 
Lys Val Val Ala Leu Ser Asn Asn Lys Lys Asp Asp Thr Lys Glu Thr
625                 630                 635                 640 
Asp Ser Leu Ser Asp Glu Val Thr His Asn Ser Asn Gln Asn Asn Ser
                645                 650                 655     
Asn Cys Ser Ser Pro Ser Arg Met Ser Asp Ser Val Ser Leu Asn Thr
            660                 665                 670         
Asp Ser Ser Gln Asp Thr Ser Leu Cys Ser Pro Val Lys Gln Thr His
        675                 680                 685             
Ile Asp Ile Asn Ser Lys Ile Arg Gln Glu Asp Glu Asn Phe Asn Ser
    690                 695                 700                 
Leu Leu Gln Asn Gly Asp Ile Leu Asn Ser Ser Thr Glu Glu Lys Phe
705                 710                 715                 720 
Lys Ala His Asp Lys Lys Asp Phe Asn Leu Pro Glu Tyr Asp Leu Asn
                725                 730                 735     
Val Glu Glu Arg Leu Val Leu Ile Glu Lys Ser Val Asp Ser Thr Ala
            740                 745                 750         
Thr Ala Asp Asp Thr His Lys Leu Asp His Ile Asn Met Asn Leu Asn
        755                 760                 765             
Lys Leu Ile Thr Asn Asp Thr Phe Gln Pro Glu Ile Met Glu Arg Ser
    770                 775                 780                 
Lys Thr Gln Asp Ile Val Leu Gly Thr Ser Phe Leu Ser Ile Asn Ser
785                 790                 795                 800 
Lys Glu Glu Thr Glu His Leu Glu Asn Gly Asn Lys Cys Pro Asn Leu
                805                 810                 815     
Glu Ser Val Asn Lys Val Asn Gly His Ser Glu Glu Thr Ser Gln Ser
            820                 825                 830         
Pro Asn Arg Thr Glu Pro His Asp Ser Asp Cys Ser Val Asp Leu Gly
        835                 840                 845             
Ile Ser Lys Ser Thr Glu Asp Leu Ser Pro Gln Lys Ser Gly Pro Val
    850                 855                 860                 
Gly Ser Val Val Lys Ser His Ser Ile Thr Asn Met Glu Ile Gly Gly
865                 870                 875                 880 
Leu Lys Ile Tyr Asp Ile Leu Ser Asp Asn Gly Pro Gln Gln Pro Ser
                885                 890                 895     
Thr Thr Val Lys Ile Thr Ser Ala Val Asp Gly Lys Asn Ile Val Arg
            900                 905                 910         
Ser Lys Ser Ala Thr Leu Leu Tyr Asp Gln Pro Leu Gln Val Phe Thr
        915                 920                 925             
Gly Ser Ser Ser Ser Ser Asp Leu Ile Ser Gly Thr Lys Ala Ile Phe
    930                 935                 940                 
Lys Phe Asp Ser Asn His Asn Pro Glu Glu Pro Asn Ile Ile Arg Gly
945                 950                 955                 960 
Pro Thr Ser Gly Pro Gln Ser Ala Pro Gln Ile Tyr Gly Pro Pro Gln
                965                 970                 975     
Tyr Asn Ile Gln Tyr Ser Ser Ser Ala Ala Val Lys Asp Thr Leu Trp
            980                 985                 990         
His Ser Lys Gln Asn Pro Gln Ile Asp His Ala Ser Phe Pro Pro Gln
        995                 1000                1005            
Leu Leu Pro Arg Ser Glu Ser Thr Glu Asn Gln Ser Tyr Ala Lys His
    1010                1015                1020                
Ser Ala Asn Met Asn Phe Ser Asn His Asn Asn Val Arg Ala Asn Thr
1025                1030                1035                1040
Ala Tyr His Leu His Gln Arg Leu Gly Pro Ala Arg His Gly Glu Met
                1045                1050                1055    
Trp Ala Ile Ser Pro Asn Asp Arg Leu Ile Pro Ala Val Thr Arg Ser
            1060                1065                1070        
Thr Ile Gln Arg Gln Ser Ser Val Ser Ser Thr Ala Ser Val Asn Leu
        1075                1080                1085            
Gly Asp Pro Gly Ser Thr Arg Arg Ala Gln Ile Pro Glu Gly Asp Tyr
    1090                1095                1100                
Leu Ser Tyr Arg Glu Phe His Ser Ala Gly Arg Thr Pro Pro Met Met
1105                1110                1115                1120
Pro Gly Ser Gln Arg Pro Leu Ser Ala Arg Thr Tyr Ser Ile Asp Gly
                1125                1130                1135    
Pro Asn Ala Ser Arg Pro Gln Ser Ala Arg Pro Ser Ile Asn Glu Ile
            1140                1145                1150        
Pro Glu Arg Thr Met Ser Val Ser Asp Phe Asn Tyr Ser Arg Thr Ser
        1155                1160                1165            
Pro Ser Lys Arg Pro Asn Ala Arg Val Gly Ser Glu His Ser Leu Leu
    1170                1175                1180                
Asp Pro Pro Gly Lys Ser Lys Val Pro Arg Asp Trp Arg Glu Gln Val
1185                1190                1195                1200
Leu Arg His Ile Glu Ala Lys Lys Leu Glu Lys Lys His Pro Gln Thr
                1205                1210                1215    
Ser Ser Ser Gly Asp Pro Cys Gln Asp Gly Ile Phe Ile Ser Gly Gln
            1220                1225                1230        
Gln Asn Tyr Ser Ser Ala Thr Leu Ser His Lys Asp Val Pro Pro Asp
        1235                1240                1245            
Ser Leu Met Lys Met Pro Leu Ser Asn Gly Gln Met Gly Gln Pro Leu
    1250                1255                1260                
Arg Pro Gln Ala Asn Tyr Ser Gln Ile His His Pro Pro Gln Ala Ser
1265                1270                1275                1280
Val Ala Arg His Pro Ser Arg Glu Gln Leu Ile Asp Tyr Leu Met Leu
                1285                1290                1295    
Lys Val Ala His Gln Pro Pro Tyr Thr Gln Pro His Cys Ser Pro Arg
            1300                1305                1310        
Gln Gly His Glu Leu Ala Lys Gln Glu Ile Arg Val Arg Val Glu Lys
        1315                1320                1325            
Asp Pro Glu Leu Gly Phe Ser Ile Ser Gly Gly Val Gly Gly Arg Gly
    1330                1335                1340                
Asn Pro Phe Arg Pro Asp Asp Asp Gly Ile Phe Val Thr Arg Val Gln
1345                1350                1355                1360
Pro Glu Gly Pro Ala Ser Lys Leu Leu Gln Pro Gly Asp Lys Ile Ile
                1365                1370                1375    
Gln Ala Asn Gly Tyr Ser Phe Ile Asn Ile Glu His Gly Gln Ala Val
            1380                1385                1390        
Ser Leu Leu Lys Thr Phe Gln Asn Thr Val Glu Leu Ile Ile Val Arg
        1395                1400                1405            
Glu Val Ser Ser
    1410        


<210> 6688
<211> 1371
<212> PRT
<213> Homo sapiens

<400> 6688
Met Thr Thr Lys Arg Ser Leu Phe Val Arg Leu Val Pro Cys Arg Cys
 1               5                  10                  15      
Leu Arg Gly Glu Glu Glu Thr Val Thr Thr Leu Asp Tyr Ser His Cys
            20                  25                  30          
Ser Leu Glu Gln Val Pro Lys Glu Ile Phe Thr Phe Glu Lys Thr Leu
        35                  40                  45              
Glu Glu Leu Tyr Leu Asp Ala Asn Gln Ile Glu Glu Leu Pro Lys Gln
    50                  55                  60                  
Leu Phe Asn Cys Gln Ser Leu His Lys Leu Ser Leu Pro Asp Asn Asp
65                  70                  75                  80  
Leu Thr Thr Leu Pro Ala Ser Ile Ala Asn Leu Ile Asn Leu Arg Glu
                85                  90                  95      
Leu Asp Val Ser Lys Asn Gly Ile Gln Glu Phe Pro Glu Asn Ile Lys
            100                 105                 110         
Asn Cys Lys Val Leu Thr Ile Val Glu Ala Ser Val Asn Pro Ile Ser
        115                 120                 125             
Lys Leu Pro Asp Gly Phe Ser Gln Leu Leu Asn Leu Thr Gln Leu Tyr
    130                 135                 140                 
Leu Asn Asp Ala Phe Leu Glu Phe Leu Pro Ala Asn Phe Gly Arg Leu
145                 150                 155                 160 
Thr Lys Leu Gln Ile Leu Glu Leu Arg Glu Asn Gln Leu Lys Met Leu
                165                 170                 175     
Pro Lys Thr Met Asn Arg Leu Thr Gln Leu Glu Arg Leu Asp Leu Gly
            180                 185                 190         
Ser Asn Glu Phe Thr Glu Val Pro Glu Val Leu Glu Gln Leu Ser Gly
        195                 200                 205             
Leu Lys Glu Phe Trp Met Asp Ala Asn Arg Leu Thr Phe Ile Pro Gly
    210                 215                 220                 
Phe Ile Gly Ser Leu Lys Gln Leu Thr Tyr Leu Asp Val Ser Lys Asn
225                 230                 235                 240 
Asn Ile Glu Met Val Glu Glu Gly Ile Ser Thr Cys Glu Asn Leu Gln
                245                 250                 255     
Asp Leu Leu Leu Ser Ser Asn Ser Leu Gln Gln Leu Pro Glu Thr Ile
            260                 265                 270         
Gly Ser Leu Lys Asn Ile Thr Thr Leu Lys Ile Asp Glu Asn Gln Leu
        275                 280                 285             
Met Tyr Leu Pro Asp Ser Ile Gly Gly Leu Ile Ser Val Glu Glu Leu
    290                 295                 300                 
Asp Cys Ser Phe Asn Glu Val Glu Ala Leu Pro Ser Ser Ile Gly Gln
305                 310                 315                 320 
Leu Thr Asn Leu Arg Thr Phe Ala Ala Asp His Asn Tyr Leu Gln Gln
                325                 330                 335     
Leu Pro Pro Glu Ile Gly Ser Trp Lys Asn Ile Thr Val Leu Phe Leu
            340                 345                 350         
His Ser Asn Lys Leu Glu Thr Leu Pro Glu Glu Met Gly Asp Met Gln
        355                 360                 365             
Lys Leu Lys Val Ile Asn Leu Ser Asp Asn Arg Leu Lys Asn Leu Pro
    370                 375                 380                 
Phe Ser Phe Thr Lys Leu Gln Gln Leu Thr Ala Met Trp Leu Ser Asp
385                 390                 395                 400 
Asn Gln Ser Lys Pro Leu Ile Pro Leu Gln Lys Glu Thr Asp Ser Glu
                405                 410                 415     
Thr Gln Lys Met Val Leu Thr Asn Tyr Met Phe Pro Gln Gln Pro Arg
            420                 425                 430         
Thr Glu Asp Val Met Phe Ile Ser Asp Asn Glu Ser Phe Asn Pro Ser
        435                 440                 445             
Leu Trp Glu Glu Gln Arg Lys Gln Arg Ala Gln Val Ala Phe Glu Cys
    450                 455                 460                 
Asp Glu Asp Lys Asp Glu Arg Glu Ala Pro Pro Arg Glu Gly Asn Leu
465                 470                 475                 480 
Lys Arg Tyr Pro Thr Pro Tyr Pro Asp Glu Leu Lys Asn Met Val Lys
                485                 490                 495     
Thr Val Gln Thr Ile Val His Arg Leu Lys Asp Glu Glu Thr Asn Glu
            500                 505                 510         
Asp Ser Gly Arg Asp Leu Lys Pro His Glu Asp Gln Gln Asp Ile Asn
        515                 520                 525             
Lys Asp Val Gly Val Lys Thr Ser Glu Ser Thr Thr Thr Val Lys Ser
    530                 535                 540                 
Lys Val Asp Glu Arg Glu Lys Tyr Met Ile Gly Asn Ser Val Gln Lys
545                 550                 555                 560 
Ile Ser Glu Pro Glu Ala Glu Ile Ser Pro Gly Ser Leu Pro Val Thr
                565                 570                 575     
Ala Asn Met Lys Ala Ser Glu Asn Leu Lys His Ile Val Asn His Asp
            580                 585                 590         
Asp Val Phe Glu Glu Ser Glu Glu Leu Ser Ser Asp Glu Glu Met Lys
        595                 600                 605             
Met Ala Glu Met Arg Pro Pro Leu Ile Glu Thr Ser Ile Asn Gln Pro
    610                 615                 620                 
Lys Val Val Ala Leu Ser Asn Asn Lys Lys Asp Asp Thr Lys Glu Thr
625                 630                 635                 640 
Asp Ser Leu Ser Asp Glu Val Thr His Asn Ser Asn Gln Asn Asn Ser
                645                 650                 655     
Asn Cys Ser Ser Pro Ser Arg Met Ser Asp Ser Val Ser Leu Asn Thr
            660                 665                 670         
Asp Ser Ser Gln Asp Thr Ser Leu Cys Ser Pro Val Lys Gln Thr His
        675                 680                 685             
Ile Asp Ile Asn Ser Lys Ile Arg Gln Glu Asp Glu Asn Phe Asn Ser
    690                 695                 700                 
Leu Leu Gln Asn Gly Asp Ile Leu Asn Ser Ser Thr Glu Glu Lys Phe
705                 710                 715                 720 
Lys Ala His Asp Lys Lys Asp Phe Asn Leu Pro Glu Tyr Asp Leu Asn
                725                 730                 735     
Val Glu Glu Arg Leu Val Leu Ile Glu Lys Ser Val Asp Ser Thr Ala
            740                 745                 750         
Thr Ala Asp Asp Thr His Lys Leu Asp His Ile Asn Met Asn Leu Asn
        755                 760                 765             
Lys Leu Ile Thr Asn Asp Thr Phe Gln Pro Glu Ile Met Glu Arg Ser
    770                 775                 780                 
Lys Thr Gln Asp Ile Val Leu Gly Thr Ser Phe Leu Ser Ile Asn Ser
785                 790                 795                 800 
Lys Glu Glu Thr Glu His Leu Glu Asn Gly Asn Lys Tyr Pro Asn Leu
                805                 810                 815     
Glu Ser Val Asn Lys Val Asn Gly His Ser Glu Glu Thr Ser Gln Ser
            820                 825                 830         
Pro Asn Arg Thr Glu Pro His Asp Ser Asp Cys Ser Val Asp Leu Gly
        835                 840                 845             
Ile Ser Lys Ser Thr Glu Asp Leu Ser Pro Gln Lys Ser Gly Pro Val
    850                 855                 860                 
Gly Ser Val Val Lys Ser His Ser Ile Thr Asn Met Glu Ile Gly Gly
865                 870                 875                 880 
Leu Lys Ile Tyr Asp Ile Leu Ser Asp Asn Gly Pro Gln Gln Pro Ser
                885                 890                 895     
Thr Thr Val Lys Ile Thr Ser Ala Val Asp Gly Lys Asn Ile Val Arg
            900                 905                 910         
Ser Lys Ser Ala Thr Leu Leu Tyr Asp Gln Pro Leu Gln Val Phe Thr
        915                 920                 925             
Gly Ser Ser Ser Ser Ser Asp Leu Ile Ser Gly Thr Lys Ala Ile Phe
    930                 935                 940                 
Lys Phe Asp Ser Asn His Asn Pro Glu Glu Pro Asn Ile Ile Arg Gly
945                 950                 955                 960 
Pro Thr Ser Gly Pro Gln Ser Ala Pro Gln Ile Tyr Gly Pro Pro Gln
                965                 970                 975     
Tyr Asn Ile Gln Tyr Ser Ser Ser Ala Ala Val Lys Asp Thr Leu Trp
            980                 985                 990         
His Ser Lys Gln Asn Pro Gln Ile Asp His Ala Ser Phe Pro Pro Gln
        995                 1000                1005            
Leu Leu Pro Arg Ser Glu Ser Thr Glu Asn Gln Ser Tyr Ala Lys His
    1010                1015                1020                
Ser Ala Asn Met Asn Phe Ser Asn His Asn Asn Val Arg Ala Asn Thr
1025                1030                1035                1040
Ala Tyr His Leu His Gln Arg Leu Gly Pro Ala Arg His Gly Glu Met
                1045                1050                1055    
Trp Ala Ile Ser Pro Asn Asp Arg Leu Ile Pro Ala Val Thr Arg Ser
            1060                1065                1070        
Thr Ile Gln Arg Gln Ser Ser Val Ser Ser Thr Ala Ser Val Asn Leu
        1075                1080                1085            
Gly Asp Pro Gly Ser Thr Arg Arg Ala Gln Ile Pro Glu Gly Asp Tyr
    1090                1095                1100                
Leu Ser Tyr Arg Glu Phe His Ser Ala Gly Arg Thr Pro Pro Met Met
1105                1110                1115                1120
Pro Gly Ser Gln Arg Pro Leu Ser Ala Arg Thr Tyr Ser Ile Asp Gly
                1125                1130                1135    
Pro Asn Ala Ser Arg Pro Gln Ser Ala Arg Pro Ser Ile Asn Glu Ile
            1140                1145                1150        
Pro Glu Arg Thr Met Ser Val Ser Asp Phe Asn Tyr Ser Arg Thr Ser
        1155                1160                1165            
Pro Ser Lys Arg Pro Asn Ala Arg Val Gly Ser Glu His Ser Leu Leu
    1170                1175                1180                
Asp Pro Pro Gly Lys Ser Lys Val Pro Arg Asp Trp Arg Glu Gln Val
1185                1190                1195                1200
Leu Arg His Ile Glu Ala Lys Lys Leu Glu Lys Met Pro Leu Ser Asn
                1205                1210                1215    
Gly Gln Met Gly Gln Pro Leu Arg Pro Gln Ala Asn Tyr Ser Gln Ile
            1220                1225                1230        
His His Pro Pro Gln Ala Ser Val Ala Arg His Pro Ser Arg Glu Gln
        1235                1240                1245            
Leu Ile Asp Tyr Leu Met Leu Lys Val Ala His Gln Pro Pro Tyr Thr
    1250                1255                1260                
Gln Pro His Cys Ser Pro Arg Gln Gly His Glu Leu Ala Lys Gln Glu
1265                1270                1275                1280
Ile Arg Val Arg Val Glu Lys Asp Pro Glu Leu Gly Phe Ser Ile Ser
                1285                1290                1295    
Gly Gly Val Gly Gly Arg Gly Asn Pro Phe Arg Pro Asp Asp Asp Gly
            1300                1305                1310        
Ile Phe Val Thr Arg Val Gln Pro Glu Gly Pro Ala Ser Lys Leu Leu
        1315                1320                1325            
Gln Pro Gly Asp Lys Ile Ile Gln Ala Asn Gly Tyr Ser Phe Ile Asn
    1330                1335                1340                
Ile Glu His Gly Gln Ala Val Ser Leu Leu Lys Thr Phe Gln Asn Thr
1345                1350                1355                1360
Val Glu Leu Ile Ile Val Arg Glu Val Ser Ser
                1365                1370    


<210> 6689
<211> 2725
<212> PRT
<213> Homo sapiens

<400> 6689
Met Asn Gly His Arg Phe Thr Phe Arg Thr Arg Ser Leu Leu Pro Leu
 1               5                  10                  15      
Gln Lys Gly Gln His Arg Cys Ile Thr Lys Leu Leu Ala His Asn Asp
            20                  25                  30          
Pro Trp Gly Ile Phe Arg Ala Pro Ser Ser Arg Arg Ser Tyr Ser Val
        35                  40                  45              
Ser Gly Val Cys Gln Pro Ala Ile Pro Asn Ser Ser Leu His Ile Pro
    50                  55                  60                  
His Asn Ala Cys Trp Leu Lys Trp Lys Leu Cys Ser Glu Ile Ala Leu
65                  70                  75                  80  
Pro Tyr His His Ile Leu Gly Glu Arg Arg Lys Leu Cys Ser Ile Arg
                85                  90                  95      
Lys Phe Glu Phe Glu Asp Trp Arg Glu Asp Val Arg Ser Cys Cys Gln
            100                 105                 110         
Ala Arg Val Leu Pro Arg Gly Arg Thr Leu Gly Leu Trp Leu Ala Leu
        115                 120                 125             
Ile Gly Arg Glu Glu Phe Ala Met Asn Leu Leu Arg Arg Ser Gly Lys
    130                 135                 140                 
Arg Arg Arg Ser Glu Ser Gly Ser Asp Ser Phe Ser Gly Ser Gly Gly
145                 150                 155                 160 
Asp Ser Ser Ala Ser Pro Gln Phe Leu Ser Gly Ser Val Leu Ser Pro
                165                 170                 175     
Pro Pro Gly Leu Gly Arg Cys Leu Lys Ala Ala Ala Ala Gly Glu Cys
            180                 185                 190         
Lys Pro Thr Val Pro Asp Tyr Glu Arg Asp Lys Leu Leu Leu Ala Asn
        195                 200                 205             
Trp Gly Leu Pro Lys Ala Val Leu Glu Lys Tyr His Ser Phe Gly Val
    210                 215                 220                 
Lys Lys Met Phe Glu Trp Gln Ala Glu Cys Leu Leu Leu Gly Gln Val
225                 230                 235                 240 
Leu Glu Gly Lys Asn Leu Val Tyr Ser Ala Pro Thr Ser Ala Gly Lys
                245                 250                 255     
Thr Leu Val Ala Glu Leu Leu Ile Leu Lys Arg Val Leu Glu Met Arg
            260                 265                 270         
Lys Lys Ala Leu Phe Ile Leu Pro Phe Val Ser Val Ala Lys Glu Lys
        275                 280                 285             
Lys Tyr Tyr Leu Gln Ser Leu Phe Gln Glu Val Gly Ile Lys Val Asp
    290                 295                 300                 
Gly Tyr Met Gly Ser Thr Ser Pro Ser Arg His Phe Ser Ser Leu Asp
305                 310                 315                 320 
Ile Ala Val Cys Thr Ile Glu Arg Ala Asn Gly Leu Ile Asn Arg Leu
                325                 330                 335     
Ile Glu Glu Asn Lys Met Asp Leu Leu Gly Met Val Val Val Asp Glu
            340                 345                 350         
Leu His Met Leu Gly Asp Ser His Arg Gly Tyr Leu Leu Glu Leu Leu
        355                 360                 365             
Leu Thr Lys Ile Cys Tyr Ile Thr Arg Lys Ser Ala Ser Cys Gln Ala
    370                 375                 380                 
Asp Leu Ala Ser Ser Leu Ser Asn Ala Val Gln Ile Val Gly Met Ser
385                 390                 395                 400 
Ala Thr Leu Pro Asn Leu Glu Leu Val Ala Ser Trp Leu Asn Ala Glu
                405                 410                 415     
Leu Tyr His Thr Asp Phe Arg Pro Val Pro Leu Leu Glu Ser Val Lys
            420                 425                 430         
Val Gly Asn Ser Ile Tyr Asp Ser Ser Met Lys Leu Val Arg Glu Phe
        435                 440                 445             
Glu Pro Met Leu Gln Val Lys Gly Asp Glu Asp His Val Val Ser Leu
    450                 455                 460                 
Cys Tyr Glu Thr Ile Cys Asp Asn His Ser Val Leu Leu Phe Cys Pro
465                 470                 475                 480 
Ser Lys Lys Trp Cys Glu Lys Leu Ala Asp Ile Ile Ala Arg Glu Phe
                485                 490                 495     
Tyr Asn Leu His His Gln Ala Glu Gly Leu Val Lys Pro Ser Glu Cys
            500                 505                 510         
Pro Pro Val Ile Leu Glu Gln Lys Glu Leu Leu Glu Val Met Asp Gln
        515                 520                 525             
Leu Arg Arg Leu Pro Ser Gly Leu Asp Ser Val Leu Gln Lys Thr Val
    530                 535                 540                 
Pro Trp Gly Val Ala Phe His His Ala Gly Leu Thr Phe Glu Glu Arg
545                 550                 555                 560 
Asp Ile Ile Glu Gly Ala Phe Arg Gln Gly Leu Ile Arg Val Leu Ala
                565                 570                 575     
Ala Thr Ser Thr Leu Ser Ser Gly Val Asn Leu Pro Ala Arg Arg Val
            580                 585                 590         
Ile Ile Arg Thr Pro Ile Phe Gly Gly Arg Pro Leu Asp Ile Leu Thr
        595                 600                 605             
Tyr Lys Gln Met Val Gly Arg Ala Gly Arg Lys Gly Val Asp Thr Val
    610                 615                 620                 
Gly Glu Ser Ile Leu Ile Cys Lys Asn Ser Glu Lys Ser Lys Gly Ile
625                 630                 635                 640 
Ala Leu Leu Gln Gly Ser Leu Lys Pro Val Arg Ser Cys Leu Gln Arg
                645                 650                 655     
Arg Glu Gly Glu Glu Val Thr Gly Ser Met Ile Arg Ala Ile Leu Glu
            660                 665                 670         
Ile Ile Val Gly Gly Val Ala Ser Thr Ser Gln Asp Met His Thr Tyr
        675                 680                 685             
Ala Ala Cys Thr Phe Leu Ala Ala Ser Met Lys Glu Gly Lys Gln Gly
    690                 695                 700                 
Ile Gln Arg Asn Gln Glu Ser Val Gln Leu Gly Ala Ile Glu Ala Cys
705                 710                 715                 720 
Val Met Trp Leu Leu Glu Asn Glu Phe Ile Gln Ser Thr Glu Ala Ser
                725                 730                 735     
Asp Gly Thr Glu Gly Lys Val Tyr His Pro Thr His Leu Gly Ser Ala
            740                 745                 750         
Thr Leu Ser Ser Ser Leu Ser Pro Ala Asp Thr Leu Asp Ile Phe Ala
        755                 760                 765             
Asp Leu Gln Arg Ala Met Lys Gly Phe Val Leu Glu Asn Asp Leu His
    770                 775                 780                 
Ile Leu Tyr Leu Val Thr Pro Met Phe Glu Asp Trp Thr Thr Ile Asp
785                 790                 795                 800 
Trp Tyr Arg Phe Phe Cys Leu Trp Glu Lys Leu Pro Thr Ser Met Lys
                805                 810                 815     
Arg Val Ala Glu Leu Val Gly Val Glu Glu Gly Phe Leu Ala Arg Cys
            820                 825                 830         
Val Lys Gly Lys Val Val Ala Arg Thr Glu Arg Gln His Arg Gln Met
        835                 840                 845             
Ala Ile His Lys Arg Phe Phe Thr Ser Leu Val Leu Leu Asp Leu Ile
    850                 855                 860                 
Ser Glu Val Pro Leu Arg Glu Ile Asn Gln Lys Tyr Gly Cys Asn Arg
865                 870                 875                 880 
Gly Gln Ile Gln Ser Leu Gln Gln Ser Ala Ala Val Tyr Ala Gly Met
                885                 890                 895     
Ile Thr Val Phe Ser Asn Arg Leu Gly Trp His Asn Met Glu Leu Leu
            900                 905                 910         
Leu Ser Gln Phe Gln Lys Arg Leu Thr Phe Gly Ile Gln Arg Glu Leu
        915                 920                 925             
Cys Asp Leu Val Arg Val Ser Leu Leu Asn Ala Gln Arg Ala Arg Val
    930                 935                 940                 
Leu Tyr Ala Ser Gly Phe His Thr Val Ala Asp Leu Ala Arg Ala Asn
945                 950                 955                 960 
Ile Val Glu Val Glu Val Ile Leu Lys Asn Ala Val Pro Phe Lys Ser
                965                 970                 975     
Ala Arg Lys Ala Val Asp Glu Glu Glu Glu Ala Val Glu Glu Arg Arg
            980                 985                 990         
Asn Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr Glu Arg
        995                 1000                1005            
Glu Ala Ala Ala Leu Ile Val Glu Glu Ala Arg Met Ile Leu Gln Gln
    1010                1015                1020                
Asp Leu Val Glu Met Gly Val Gln Trp Asn Pro Cys Ala Leu Leu His
1025                1030                1035                1040
Ser Ser Thr Cys Ser Leu Thr His Ser Glu Ser Glu Val Lys Glu His
                1045                1050                1055    
Thr Phe Ile Ser Gln Thr Lys Ser Ser Tyr Lys Lys Leu Thr Ser Lys
            1060                1065                1070        
Asn Lys Ser Asn Thr Ile Phe Ser Asp Ser Tyr Ile Lys His Ser Pro
        1075                1080                1085            
Asn Ile Val Gln Asp Leu Asn Lys Ser Arg Glu His Thr Ser Ser Phe
    1090                1095                1100                
Asn Cys Asn Phe Gln Asn Gly Asn Gln Glu His Gln Thr Cys Ser Ile
1105                1110                1115                1120
Phe Arg Ala Arg Lys Arg Ala Ser Leu Asp Ile Asn Lys Glu Lys Pro
                1125                1130                1135    
Gly Ala Ser Gln Asn Glu Gly Lys Thr Ser Asp Lys Lys Val Val Gln
            1140                1145                1150        
Thr Phe Ser Gln Lys Thr Lys Lys Ala Pro Leu Asn Phe Asn Ser Glu
        1155                1160                1165            
Lys Met Ser Arg Ser Phe Arg Ser Trp Lys Arg Arg Lys His Leu Lys
    1170                1175                1180                
Arg Ser Arg Asp Ser Ser Pro Leu Lys Asp Ser Gly Ala Cys Arg Ile
1185                1190                1195                1200
His Leu Gln Gly Gln Thr Leu Ser Asn Pro Ser Leu Cys Glu Asp Pro
                1205                1210                1215    
Phe Thr Leu Asp Glu Lys Lys Thr Glu Phe Arg Asn Ser Gly Pro Phe
            1220                1225                1230        
Ala Lys Asn Val Ser Leu Ser Gly Lys Glu Lys Asp Asn Lys Thr Ser
        1235                1240                1245            
Phe Pro Leu Gln Ile Lys Gln Asn Cys Ser Trp Asn Ile Thr Leu Thr
    1250                1255                1260                
Asn Asp Asn Phe Val Glu His Ile Val Thr Gly Ser Gln Ser Lys Asn
1265                1270                1275                1280
Val Thr Cys Gln Ala Thr Ser Val Val Ser Glu Lys Gly Arg Gly Val
                1285                1290                1295    
Ala Val Glu Ala Glu Lys Ile Asn Glu Val Leu Ile Gln Asn Gly Ser
            1300                1305                1310        
Lys Asn Gln Asn Val Tyr Met Lys His His Asp Ile His Pro Ile Asn
        1315                1320                1325            
Gln Tyr Leu Arg Lys Gln Ser His Glu Gln Thr Ser Thr Ile Thr Lys
    1330                1335                1340                
Gln Lys Asn Ile Ile Glu Arg Gln Met Pro Cys Glu Ala Val Ser Ser
1345                1350                1355                1360
Tyr Ile Asn Arg Asp Ser Asn Val Thr Ile Asn Cys Glu Arg Ile Lys
                1365                1370                1375    
Leu Asn Thr Glu Glu Asn Lys Pro Ser His Phe Gln Ala Leu Gly Asp
            1380                1385                1390        
Asp Ile Ser Arg Thr Val Ile Pro Ser Glu Val Leu Pro Ser Ala Gly
        1395                1400                1405            
Ala Phe Ser Lys Ser Glu Gly Gln His Glu Asn Phe Leu Asn Ile Ser
    1410                1415                1420                
Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn
1425                1430                1435                1440
Asn His Val Ser Asp Leu Gly Leu Val Leu Cys Asp Phe Glu Asp Ser
                1445                1450                1455    
Phe Tyr Leu Asp Thr Gln Ser Glu Lys Ile Ile Gln Gln Met Ala Thr
            1460                1465                1470        
Glu Asn Ala Lys Leu Gly Ala Lys Asp Thr Asn Leu Ala Ala Gly Ile
        1475                1480                1485            
Met Gln Lys Ser Leu Val Gln Gln Asn Ser Met Asn Ser Phe Gln Lys
    1490                1495                1500                
Glu Cys His Ile Pro Phe Pro Ala Glu Gln His Pro Leu Gly Ala Thr
1505                1510                1515                1520
Lys Ile Asp His Leu Asp Leu Lys Thr Val Gly Thr Met Lys Gln Ser
                1525                1530                1535    
Ser Asp Ser His Gly Val Asp Ile Leu Thr Pro Glu Ser Pro Ile Phe
            1540                1545                1550        
His Ser Pro Ile Leu Leu Glu Glu Asn Gly Leu Phe Leu Lys Lys Asn
        1555                1560                1565            
Glu Val Ser Val Thr Asp Ser Gln Leu Asn Ser Phe Leu Gln Gly Tyr
    1570                1575                1580                
Gln Thr Gln Glu Thr Val Lys Pro Val Ile Leu Leu Ile Pro Gln Lys
1585                1590                1595                1600
Arg Thr Pro Thr Gly Val Glu Gly Glu Cys Leu Pro Val Pro Glu Thr
                1605                1610                1615    
Ser Leu Asn Met Ser Asp Ser Leu Leu Phe Asp Ser Phe Ser Asp Asp
            1620                1625                1630        
Tyr Leu Val Lys Glu Gln Leu Pro Asp Met Gln Met Lys Glu Pro Leu
        1635                1640                1645            
Pro Ser Glu Val Thr Ser Asn His Phe Ser Asp Ser Leu Cys Leu Gln
    1650                1655                1660                
Glu Asp Leu Ile Lys Lys Ser Asn Val Asn Glu Asn Gln Asp Thr His
1665                1670                1675                1680
Gln Gln Leu Thr Cys Ser Asn Asp Glu Ser Ile Ile Phe Ser Glu Met
                1685                1690                1695    
Asp Ser Val Gln Met Val Glu Ala Leu Asp Asn Val Asp Ile Phe Pro
            1700                1705                1710        
Val Gln Glu Lys Asn His Thr Val Val Ser Pro Arg Ala Leu Glu Leu
        1715                1720                1725            
Ser Asp Pro Val Leu Asp Glu His His Gln Gly Asp Gln Asp Gly Gly
    1730                1735                1740                
Asp Gln Asp Glu Arg Ala Glu Lys Ser Lys Leu Thr Gly Thr Arg Gln
1745                1750                1755                1760
Asn His Ser Phe Ile Trp Ser Gly Ala Ser Phe Asp Leu Ser Pro Gly
                1765                1770                1775    
Leu Gln Arg Ile Leu Asp Lys Val Ser Ser Pro Leu Glu Asn Glu Lys
            1780                1785                1790        
Leu Lys Ser Met Thr Ile Asn Phe Ser Ser Leu Asn Arg Lys Asn Thr
        1795                1800                1805            
Glu Leu Asn Glu Glu Gln Glu Val Ile Ser Asn Leu Glu Thr Lys Gln
    1810                1815                1820                
Val Gln Gly Ile Ser Phe Ser Ser Asn Asn Glu Val Lys Ser Lys Ile
1825                1830                1835                1840
Glu Met Leu Glu Asn Asn Ala Asn His Asp Glu Thr Ser Ser Leu Leu
                1845                1850                1855    
Pro Arg Lys Glu Ser Asn Ile Val Asp Asp Asn Gly Leu Ile Pro Pro
            1860                1865                1870        
Thr Pro Ile Pro Thr Ser Ala Ser Lys Leu Thr Phe Pro Gly Ile Leu
        1875                1880                1885            
Glu Thr Pro Val Asn Pro Trp Lys Thr Asn Asn Val Leu Gln Pro Gly
    1890                1895                1900                
Glu Ser Tyr Leu Phe Gly Ser Pro Ser Asp Ile Lys Asn His Asp Leu
1905                1910                1915                1920
Ser Pro Gly Ser Arg Asn Gly Phe Lys Asp Asn Ser Pro Ile Ser Asp
                1925                1930                1935    
Thr Ser Phe Ser Leu Gln Leu Ser Gln Asp Gly Leu Gln Leu Thr Pro
            1940                1945                1950        
Ala Ser Ser Ser Ser Glu Ser Leu Ser Ile Ile Asp Val Ala Ser Asp
        1955                1960                1965            
Gln Asn Leu Phe Gln Thr Phe Ile Lys Glu Trp Arg Cys Lys Lys Arg
    1970                1975                1980                
Phe Ser Ile Ser Leu Ala Cys Glu Lys Ile Arg Ser Leu Thr Ser Ser
1985                1990                1995                2000
Lys Thr Ala Thr Ile Gly Ser Arg Phe Lys Gln Ala Ser Ser Pro Gln
                2005                2010                2015    
Glu Ile Pro Ile Arg Asp Asp Gly Phe Pro Ile Lys Gly Cys Asp Asp
            2020                2025                2030        
Thr Leu Val Val Gly Leu Ala Val Cys Trp Gly Gly Arg Asp Ala Tyr
        2035                2040                2045            
Tyr Phe Ser Leu Gln Lys Glu Gln Lys His Ser Glu Ile Ser Ala Ser
    2050                2055                2060                
Leu Val Pro Pro Ser Leu Asp Pro Ser Leu Thr Leu Lys Asp Arg Met
2065                2070                2075                2080
Trp Tyr Leu Gln Ser Cys Leu Arg Lys Glu Ser Asp Lys Glu Cys Ser
                2085                2090                2095    
Val Val Ile Tyr Asp Phe Ile Gln Ser Tyr Lys Ile Leu Leu Leu Ser
            2100                2105                2110        
Cys Gly Ile Ser Leu Glu Gln Ser Tyr Glu Asp Pro Lys Val Ala Cys
        2115                2120                2125            
Trp Leu Leu Asp Pro Asp Ser Gln Glu Pro Thr Leu His Ser Ile Val
    2130                2135                2140                
Thr Ser Phe Leu Pro His Glu Leu Pro Leu Leu Glu Gly Met Glu Thr
2145                2150                2155                2160
Ser Gln Gly Ile Gln Ser Leu Gly Leu Asn Ala Gly Ser Glu His Ser
                2165                2170                2175    
Gly Arg Tyr Arg Ala Ser Val Glu Ser Ile Leu Ile Phe Asn Ser Met
            2180                2185                2190        
Asn Gln Leu Asn Ser Leu Leu Gln Lys Glu Asn Leu Gln Asp Val Phe
        2195                2200                2205            
Arg Lys Val Glu Met Pro Ser Gln Tyr Cys Leu Ala Leu Leu Glu Leu
    2210                2215                2220                
Asn Gly Ile Gly Phe Ser Thr Ala Glu Cys Glu Ser Gln Lys His Ile
2225                2230                2235                2240
Met Gln Ala Lys Leu Asp Ala Ile Glu Thr Gln Ala Tyr Gln Leu Ala
                2245                2250                2255    
Gly His Ser Phe Ser Phe Thr Ser Ser Asp Asp Ile Ala Glu Val Leu
            2260                2265                2270        
Phe Leu Glu Leu Lys Leu Pro Pro Asn Arg Glu Met Lys Asn Gln Gly
        2275                2280                2285            
Ser Lys Lys Thr Leu Gly Ser Thr Arg Arg Gly Ile Asp Asn Gly Arg
    2290                2295                2300                
Lys Leu Arg Leu Gly Arg Gln Phe Ser Thr Ser Lys Asp Val Leu Asn
2305                2310                2315                2320
Lys Leu Lys Ala Leu His Pro Leu Pro Gly Leu Ile Leu Glu Trp Arg
                2325                2330                2335    
Arg Ile Thr Asn Ala Ile Thr Lys Val Val Phe Pro Leu Gln Arg Glu
            2340                2345                2350        
Lys Cys Leu Asn Pro Phe Leu Gly Met Glu Arg Ile Tyr Pro Val Ser
        2355                2360                2365            
Gln Ser His Thr Ala Thr Gly Arg Ile Thr Phe Thr Glu Pro Asn Ile
    2370                2375                2380                
Gln Asn Val Pro Arg Asp Phe Glu Ile Lys Met Pro Thr Leu Val Gly
2385                2390                2395                2400
Glu Ser Pro Pro Ser Gln Ala Val Gly Lys Gly Leu Leu Pro Met Gly
                2405                2410                2415    
Arg Gly Lys Tyr Lys Lys Gly Phe Ser Val Asn Pro Arg Cys Gln Ala
            2420                2425                2430        
Gln Met Glu Glu Arg Ala Ala Asp Arg Gly Met Pro Phe Ser Ile Ser
        2435                2440                2445            
Met Arg His Ala Phe Val Pro Phe Pro Gly Gly Ser Ile Leu Ala Ala
    2450                2455                2460                
Asp Tyr Ser Gln Leu Glu Leu Arg Ile Leu Ala His Leu Ser His Asp
2465                2470                2475                2480
Arg Arg Leu Ile Gln Val Leu Asn Thr Gly Ala Asp Val Phe Arg Ser
                2485                2490                2495    
Ile Ala Ala Glu Trp Lys Met Ile Glu Pro Glu Ser Val Gly Asp Asp
            2500                2505                2510        
Leu Arg Gln Gln Ala Lys Gln Ile Cys Tyr Gly Ile Ile Tyr Gly Met
        2515                2520                2525            
Gly Ala Lys Ser Leu Gly Glu Gln Met Gly Ile Lys Glu Asn Asp Ala
    2530                2535                2540                
Ala Cys Tyr Ile Asp Ser Phe Lys Ser Arg Tyr Thr Gly Ile Asn Gln
2545                2550                2555                2560
Phe Met Thr Glu Thr Val Lys Asn Cys Lys Arg Asp Gly Phe Val Gln
                2565                2570                2575    
Thr Ile Leu Gly Arg Arg Arg Tyr Leu Pro Gly Ile Lys Asp Asn Asn
            2580                2585                2590        
Pro Tyr Arg Lys Ala His Ala Glu Arg Gln Ala Ile Asn Thr Ile Val
        2595                2600                2605            
Gln Gly Ser Ala Ala Asp Ile Val Lys Ile Ala Thr Val Asn Ile Gln
    2610                2615                2620                
Lys Gln Leu Glu Thr Phe His Ser Thr Phe Lys Ser His Gly His Arg
2625                2630                2635                2640
Glu Gly Met Leu Gln Ser Asp Gln Thr Gly Leu Ser Arg Lys Arg Lys
                2645                2650                2655    
Leu Gln Gly Met Phe Cys Pro Ile Arg Gly Gly Phe Phe Ile Leu Gln
            2660                2665                2670        
Leu His Asp Glu Leu Leu Tyr Glu Val Ala Glu Glu Asp Val Val Gln
        2675                2680                2685            
Val Ala Gln Ile Val Lys Asn Glu Met Glu Ser Ala Val Lys Leu Ser
    2690                2695                2700                
Val Lys Leu Lys Val Lys Val Lys Ile Gly Ala Ser Trp Gly Glu Leu
2705                2710                2715                2720
Lys Asp Phe Asp Val
                2725


<210> 6690
<211> 1740
<212> PRT
<213> Homo sapiens

<400> 6690
Ser Glu Ala Asn Cys Ser Trp Asp Lys Val Ile Ile Asp Arg Thr Asp
 1               5                  10                  15      
Lys Glu Ala Trp Pro Ser Ile Thr Gly Thr Glu Thr Glu Ser Ala Ser
            20                  25                  30          
Glu Cys Thr Thr Asp Thr Asp Ser Ala Ser Asn Cys Gly Ser Glu Asn
        35                  40                  45              
Ser Ser Met Ala Thr Gly Ser Ala Gln Gly Asn Phe Thr Gly His Thr
    50                  55                  60                  
Lys Lys Thr Asn Gly Asn Asn Gly Thr Asn Gly Ala Leu Val Gln Ser
65                  70                  75                  80  
Pro Ser Asn Gln Ser Ala Leu Gly Ala Gly Gly Ala Asn Ser Asn Gly
                85                  90                  95      
Ser Ala Ala Arg Val Trp Gly Val Ala Thr Gly Ser Ser Ser Gly Leu
            100                 105                 110         
Ala His Cys Ser Val Ser Gly Gly Asp Gly Lys Met Asp Thr Met Ile
        115                 120                 125             
Gly Asp Gly Arg Ser Gln Asn Cys Trp Gly Ala Ser Asn Ser Asn Ala
    130                 135                 140                 
Gly Ile Asn Leu Asn Leu Asn Pro Asn Ala Asn Pro Ala Ala Trp Pro
145                 150                 155                 160 
Val Leu Gly His Glu Gly Thr Val Ala Thr Gly Asn Pro Ser Ser Ile
                165                 170                 175     
Cys Ser Pro Val Ser Ala Ile Gly Gln Asn Met Gly Asn Gln Asn Gly
            180                 185                 190         
Asn Pro Thr Gly Thr Leu Gly Ala Trp Gly Asn Leu Leu Pro Gln Glu
        195                 200                 205             
Ser Thr Glu Pro Gln Thr Ser Thr Ser Gln Asn Val Ser Phe Ser Ala
    210                 215                 220                 
Gln Pro Gln Asn Leu Asn Thr Asp Gly Pro Asn Asn Thr Asn Pro Met
225                 230                 235                 240 
Asn Ser Ser Pro Asn Pro Ile Asn Ala Met Gln Thr Asn Gly Leu Pro
                245                 250                 255     
Asn Trp Gly Met Ala Val Gly Met Gly Ala Ile Ile Pro Pro His Leu
            260                 265                 270         
Gln Gly Leu Pro Gly Ala Asn Gly Ser Ser Val Ser Gln Val Ser Gly
        275                 280                 285             
Gly Ser Ala Glu Gly Ile Ser Asn Ser Val Trp Gly Leu Ser Pro Gly
    290                 295                 300                 
Asn Pro Ala Thr Gly Asn Ser Asn Ser Gly Phe Ser Gln Gly Asn Gly
305                 310                 315                 320 
Asp Thr Val Asn Ser Ala Leu Ser Ala Lys Gln Asn Gly Ser Ser Ser
                325                 330                 335     
Ala Val Gln Lys Glu Gly Ser Gly Gly Asn Ala Trp Asp Ser Gly Pro
            340                 345                 350         
Pro Ala Gly Pro Gly Ile Leu Ala Trp Gly Arg Gly Ser Gly Asn Asn
        355                 360                 365             
Gly Val Gly Asn Ile His Ser Gly Ala Trp Gly His Pro Ser Arg Ser
    370                 375                 380                 
Thr Ser Asn Gly Val Asn Gly Glu Trp Gly Lys Pro Pro Asn Gln His
385                 390                 395                 400 
Ser Asn Ser Asp Ile Asn Gly Lys Gly Ser Thr Gly Trp Glu Ser Pro
                405                 410                 415     
Ser Val Thr Ser Gln Asn Pro Thr Val Gln Pro Gly Gly Glu His Met
            420                 425                 430         
Asn Ser Trp Ala Lys Ala Ala Ser Ser Gly Thr Thr Ala Ser Glu Gly
        435                 440                 445             
Ser Ser Asp Gly Ser Gly Asn His Asn Glu Gly Ser Thr Gly Arg Glu
    450                 455                 460                 
Gly Thr Gly Glu Gly Arg Arg Arg Asp Lys Gly Ile Ile Asp Gln Gly
465                 470                 475                 480 
His Ile Gln Leu Pro Arg Asn Asp Leu Asp Pro Arg Val Leu Ser Asn
                485                 490                 495     
Thr Gly Trp Gly Gln Thr Pro Val Lys Gln Asn Thr Ala Trp Glu Phe
            500                 505                 510         
Glu Glu Ser Pro Arg Ser Glu Arg Lys Asn Asp Asn Gly Thr Glu Ala
        515                 520                 525             
Trp Gly Cys Ala Ala Thr Gln Ala Ser Asn Ser Gly Gly Lys Asn Asp
    530                 535                 540                 
Gly Ser Ile Met Asn Ser Thr Asn Thr Ser Ser Val Ser Gly Trp Val
545                 550                 555                 560 
Asn Ala Pro Pro Ala Ala Val Pro Ala Asn Thr Gly Trp Gly Asp Ser
                565                 570                 575     
Asn Asn Lys Ala Pro Ser Gly Pro Gly Val Trp Gly Asp Ser Ile Ser
            580                 585                 590         
Ser Thr Ala Val Ser Thr Ala Ala Ala Ala Lys Ser Gly His Ala Trp
        595                 600                 605             
Ser Gly Ala Ala Asn Gln Glu Asp Lys Ser Pro Thr Trp Gly Glu Pro
    610                 615                 620                 
Pro Lys Pro Lys Ser Gln His Trp Gly Asp Gly Gln Arg Ser Asn Pro
625                 630                 635                 640 
Ala Trp Ser Ala Gly Gly Gly Asp Trp Ala Asp Ser Ser Ser Val Leu
                645                 650                 655     
Gly His Leu Gly Asp Gly Lys Lys Asn Gly Ser Gly Trp Asp Ala Asp
            660                 665                 670         
Ser Asn Arg Ser Gly Ser Gly Trp Asn Asp Thr Thr Arg Ser Gly Asn
        675                 680                 685             
Ser Gly Trp Gly Asn Ser Thr Asn Thr Lys Ala Asn Pro Gly Thr Asn
    690                 695                 700                 
Trp Gly Glu Thr Leu Lys Pro Gly Pro Gln Gln Asn Trp Ala Ser Lys
705                 710                 715                 720 
Pro Gln Asp Asn Asn Val Ser Asn Trp Gly Gly Ala Ala Ser Val Lys
                725                 730                 735     
Gln Thr Gly Thr Gly Trp Ile Gly Gly Pro Val Pro Val Lys Gln Lys
            740                 745                 750         
Asp Ser Ser Glu Ala Thr Gly Trp Glu Glu Pro Ser Pro Pro Ser Ile
        755                 760                 765             
Arg Arg Lys Met Glu Ile Asp Asp Gly Thr Ser Ala Trp Gly Asp Pro
    770                 775                 780                 
Ser Asn Tyr Asn Asn Lys Thr Val Asn Met Trp Asp Arg Asn Asn Pro
785                 790                 795                 800 
Val Ile Gln Ser Ser Thr Thr Thr Asn Thr Thr Thr Thr Thr Thr Thr
                805                 810                 815     
Thr Thr Ser Asn Thr Thr His Arg Val Glu Thr Pro Pro Pro His Gln
            820                 825                 830         
Ala Gly Thr Gln Leu Asn Arg Ser Pro Leu Leu Gly Pro Gly Arg Lys
        835                 840                 845             
Val Ser Ser Gly Trp Gly Glu Met Pro Asn Val His Ser Lys Thr Glu
    850                 855                 860                 
Asn Ser Trp Gly Glu Pro Ser Ser Pro Ser Thr Leu Val Asp Asn Gly
865                 870                 875                 880 
Thr Ala Ala Trp Gly Lys Pro Pro Ser Ser Gly Ser Gly Trp Gly Asp
                885                 890                 895     
His Pro Ala Glu Pro Pro Val Ala Phe Gly Arg Ala Gly Ala Pro Val
            900                 905                 910         
Ala Ala Ser Ala Leu Cys Lys Pro Ala Ser Lys Ser Met Gln Glu Gly
        915                 920                 925             
Trp Gly Ser Gly Gly Asp Glu Met Asn Leu Ser Thr Ser Gln Trp Glu
    930                 935                 940                 
Asp Glu Glu Gly Asp Val Trp Asn Asn Ala Ala Ser Gln Glu Ser Thr
945                 950                 955                 960 
Ser Ser Cys Ser Ser Trp Gly Asn Ala Pro Lys Lys Gly Leu Gln Lys
                965                 970                 975     
Gly Met Lys Thr Ser Gly Lys Gln Asp Glu Ala Trp Ile Met Ser Arg
            980                 985                 990         
Leu Ile Lys Gln Leu Thr Asp Met Gly Phe Pro Arg Glu Pro Ala Glu
        995                 1000                1005            
Glu Ala Leu Lys Ser Asn Asn Met Asn Leu Asp Gln Ala Met Ser Ala
    1010                1015                1020                
Leu Leu Glu Lys Lys Val Asp Val Asp Lys Arg Gly Leu Gly Val Thr
1025                1030                1035                1040
Asp His Asn Gly Met Ala Ala Lys Pro Leu Gly Cys Arg Pro Pro Ile
                1045                1050                1055    
Ser Lys Glu Ser Ser Val Asp Arg Pro Thr Phe Leu Asp Lys Asp Gly
            1060                1065                1070        
Gly Leu Val Glu Glu Pro Thr Pro Ser Pro Phe Leu Pro Ser Pro Ser
        1075                1080                1085            
Leu Lys Leu Pro Leu Ser His Ser Ala Leu Pro Ser Gln Ala Leu Gly
    1090                1095                1100                
Gly Ile Ala Ser Gly Leu Gly Met Gln Asn Leu Asn Ser Ser Arg Gln
1105                1110                1115                1120
Ile Pro Ser Gly Asn Leu Gly Met Phe Gly Asn Ser Gly Ala Ala Gln
                1125                1130                1135    
Ala Arg Thr Met Gln Gln Pro Pro Gln Pro Pro Val Gln Pro Leu Asn
            1140                1145                1150        
Ser Ser Gln Pro Ser Leu Arg Ala Gln Val Pro Gln Phe Leu Ser Pro
        1155                1160                1165            
Gln Val Gln Ala Gln Leu Leu Gln Phe Ala Ala Lys Asn Ile Gly Leu
    1170                1175                1180                
Asn Pro Ala Leu Leu Thr Ser Pro Ile Asn Pro Gln His Met Thr Met
1185                1190                1195                1200
Leu Asn Gln Leu Tyr Gln Leu Gln Leu Ala Tyr Gln Arg Leu Gln Ile
                1205                1210                1215    
Gln Gln Gln Met Leu Gln Ala Gln Arg Asn Val Ser Gly Ser Met Arg
            1220                1225                1230        
Gln Gln Glu Gln Gln Val Ala Arg Thr Ile Thr Asn Leu Gln Gln Gln
        1235                1240                1245            
Ile Gln Gln His Gln Arg Gln Leu Ala Gln Ala Leu Leu Val Lys Gln
    1250                1255                1260                
Pro Pro Pro Pro Pro Pro Pro Pro His Leu Ser Leu His Pro Ser Ala
1265                1270                1275                1280
Gly Lys Ser Ala Met Asp Ser Phe Pro Ser His Pro Gln Thr Pro Gly
                1285                1290                1295    
Leu Pro Asp Leu Gln Thr Lys Glu Gln Gln Ser Ser Pro Asn Thr Phe
            1300                1305                1310        
Ala Pro Tyr Pro Leu Ala Gly Leu Asn Pro Asn Met Asn Val Asn Ser
        1315                1320                1325            
Met Asp Met Thr Gly Gly Leu Ser Val Lys Asp Pro Ser Gln Ser Gln
    1330                1335                1340                
Ser Arg Leu Pro Gln Trp Thr His Pro Asn Ser Met Asp Asn Leu Pro
1345                1350                1355                1360
Ser Ala Ala Ser Pro Leu Glu Gln Asn Pro Ser Lys His Gly Ala Ile
                1365                1370                1375    
Pro Gly Gly Leu Ser Ile Gly Pro Pro Gly Lys Ser Ser Ile Asp Asp
            1380                1385                1390        
Ser Tyr Gly Arg Tyr Asp Leu Ile Gln Asn Ser Glu Ser Pro Ala Ser
        1395                1400                1405            
Pro Pro Val Ala Val Pro His Ser Trp Ser Arg Ala Lys Ser Asp Ser
    1410                1415                1420                
Asp Lys Ile Ser Asn Gly Ser Ser Ile Asn Trp Pro Pro Glu Phe His
1425                1430                1435                1440
Pro Gly Val Pro Trp Lys Gly Leu Gln Asn Ile Asp Pro Glu Asn Asp
                1445                1450                1455    
Pro Asp Val Thr Pro Gly Ser Val Pro Thr Gly Pro Thr Ile Asn Thr
            1460                1465                1470        
Thr Ile Gln Asp Val Asn Arg Tyr Leu Leu Lys Ser Gly Gly Lys Leu
        1475                1480                1485            
Ser Asp Ile Lys Ser Thr Trp Ser Ser Gly Pro Thr Ser His Thr Gln
    1490                1495                1500                
Ala Ser Leu Ser His Glu Leu Trp Lys Val Pro Arg Asn Ser Thr Ala
1505                1510                1515                1520
Pro Thr Arg Pro Pro Pro Gly Leu Thr Asn Pro Lys Pro Ser Ser Thr
                1525                1530                1535    
Trp Gly Ala Ser Pro Leu Gly Trp Thr Ser Ser Tyr Ser Ser Gly Ser
            1540                1545                1550        
Ala Trp Ser Thr Asp Thr Ser Gly Arg Thr Ser Ser Trp Leu Val Leu
        1555                1560                1565            
Arg Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys
    1570                1575                1580                
Leu Gln His Gly Pro Leu Ile Thr Phe His Leu Asn Leu Thr Gln Gly
1585                1590                1595                1600
Asn Ala Val Val Arg Tyr Ser Ser Lys Glu Glu Ala Ala Lys Ala Gln
                1605                1610                1615    
Lys Ser Leu His Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu
            1620                1625                1630        
Phe Ala Gly Glu Glu Glu Val Asn Arg Phe Leu Ala Gln Gly Gln Ala
        1635                1640                1645            
Leu Pro Pro Thr Ser Ser Trp Gln Ser Ser Ser Ala Ser Ser Gln Pro
    1650                1655                1660                
Arg Leu Ser Ala Ala Gly Ser Ser His Gly Leu Val Arg Ser Asp Ala
1665                1670                1675                1680
Gly His Trp Asn Ala Pro Cys Leu Gly Gly Lys Gly Ser Ser Glu Leu
                1685                1690                1695    
Leu Trp Gly Gly Val Pro Gln Tyr Ser Ser Ser Leu Trp Gly Pro Pro
            1700                1705                1710        
Ser Ala Asp Asp Ser Arg Val Ile Gly Ser Pro Thr Pro Leu Thr Thr
        1715                1720                1725            
Leu Leu Pro Gly Asp Leu Leu Ser Gly Glu Ser Leu
    1730                1735                1740


<210> 6691
<211> 1031
<212> PRT
<213> Homo sapiens

<400> 6691
Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu
 1               5                  10                  15      
Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His
            20                  25                  30          
Lys Ala Arg Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser
        35                  40                  45              
Glu Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met
    50                  55                  60                  
Leu Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe
65                  70                  75                  80  
Arg Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn
                85                  90                  95      
Met Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys
            100                 105                 110         
Val Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His
        115                 120                 125             
Lys Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile
    130                 135                 140                 
Ser His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn
145                 150                 155                 160 
Leu Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg
                165                 170                 175     
Trp Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser
            180                 185                 190         
Val Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly
        195                 200                 205             
Gln Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile
    210                 215                 220                 
Gln Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr
225                 230                 235                 240 
Ser Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro
                245                 250                 255     
Gln Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu
            260                 265                 270         
Asp Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu
        275                 280                 285             
Thr Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu
    290                 295                 300                 
Asp Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu
305                 310                 315                 320 
Ser Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu
                325                 330                 335     
Gln Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val
            340                 345                 350         
Gly Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu
        355                 360                 365             
Asn Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr
    370                 375                 380                 
Tyr Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn
385                 390                 395                 400 
Asn Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr
                405                 410                 415     
Glu Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr
            420                 425                 430         
Lys Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe
        435                 440                 445             
Met Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys
    450                 455                 460                 
Gln Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser
465                 470                 475                 480 
Pro Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser
                485                 490                 495     
Lys Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro
            500                 505                 510         
Ser Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro
        515                 520                 525             
Thr Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser
    530                 535                 540                 
Pro Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg
545                 550                 555                 560 
Thr Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu
                565                 570                 575     
His Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser
            580                 585                 590         
Phe Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg
        595                 600                 605             
Pro His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys
    610                 615                 620                 
Gly Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala
625                 630                 635                 640 
Asn Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro
                645                 650                 655     
Glu Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly
            660                 665                 670         
Thr Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His
        675                 680                 685             
Asp Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu
    690                 695                 700                 
Tyr Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro
705                 710                 715                 720 
Ser Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg
                725                 730                 735     
Val Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys
            740                 745                 750         
Arg Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His
        755                 760                 765             
Ser Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met
    770                 775                 780                 
Lys Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro
785                 790                 795                 800 
Asp Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser
                805                 810                 815     
Ser Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr
            820                 825                 830         
Gln Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser
        835                 840                 845             
Ala Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr
    850                 855                 860                 
Ala Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu
865                 870                 875                 880 
Ser Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro
                885                 890                 895     
Lys Gly Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg
            900                 905                 910         
Arg Gln Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg
        915                 920                 925             
Thr Thr Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys
    930                 935                 940                 
Pro His Thr Pro Cys Val Pro Asn Arg Ala Leu His Arg Pro Ile Ser
945                 950                 955                 960 
Ser Pro Ala Pro Tyr Pro Val Leu Gln Val Arg Gly Thr Ser Met Cys
                965                 970                 975     
Pro Thr Leu Gln Val Arg Gly Thr Asp Ala Phe Ser Cys Pro Thr Gln
            980                 985                 990         
Gln Ser Gly Phe Ser Phe Phe Val Arg His Val Met Arg Glu Ala Leu
        995                 1000                1005            
Ile His Arg Ala Gln Val Asn Gln Ala Ala Leu Leu Thr Tyr His Glu
    1010                1015                1020                
Asn Ala Ala Leu Thr Gly Lys
1025                1030    


<210> 6692
<211> 115
<212> PRT
<213> Homo sapiens

<400> 6692
Met Pro Arg Arg Arg Arg Arg Arg Gly Ser Ser Gly Ala Gly Gly Arg
 1               5                  10                  15      
Gly Arg Thr Cys Ser Arg Thr Val Arg Ala Glu Leu Ser Phe Ser Val
            20                  25                  30          
Ser Gln Val Glu Arg Ser Leu Arg Glu Gly His Tyr Ala Gln Arg Leu
        35                  40                  45              
Ser Arg Thr Ala Pro Val Tyr Leu Ala Ala Val Ile Glu Tyr Leu Thr
    50                  55                  60                  
Ala Lys Val Leu Glu Leu Ala Gly Asn Glu Ala Gln Asn Ser Gly Glu
65                  70                  75                  80  
Arg Asn Ile Thr Pro Leu Leu Leu Asp Met Val Val His Asn Asp Arg
                85                  90                  95      
Leu Leu Ser Thr Leu Phe Asn Thr Thr Thr Ile Ser Gln Val Ala Pro
            100                 105                 110         
Gly Glu Asp
        115 


<210> 6693
<211> 687
<212> PRT
<213> Homo sapiens

<400> 6693
Met Asp Gly Gly Ala Leu Thr Asp Thr Ser Leu Thr Asp Ser Tyr Phe
 1               5                  10                  15      
Ser Thr Ser Phe Ile Gly Val Asn Gly Phe Gly Ser Pro Val Glu Thr
            20                  25                  30          
Lys Tyr Pro Leu Met Gln Arg Met Thr Asn Ser Ser Ser Ser Pro Ser
        35                  40                  45              
Leu Leu Asn Asp Ser Ala Lys Pro Tyr Ser Ala His Asp Pro Leu Thr
    50                  55                  60                  
Ser Pro Ala Ser Ser Leu Phe Asn Asp Phe Gly Ala Leu Asn Ile Ser
65                  70                  75                  80  
Gln Arg Gln Lys Thr Pro Asn Pro Thr Ala Ser Glu Phe Ile Pro Lys
                85                  90                  95      
Gly Gly Ser Thr Ser Arg Leu Ser Asn Val Ser Gln Ser Asn Met Ser
            100                 105                 110         
Ala Phe Ser Gln Val Phe Ser His Pro Ser Met Gly Ser Pro Ala Thr
        115                 120                 125             
Ala Gly Leu Ala Pro Gly Met Ser Leu Ser Ala Gly Ser Ser Pro Leu
    130                 135                 140                 
His Ser Pro Lys Ile Thr Pro His Thr Ser Pro Ala Pro Arg Arg Arg
145                 150                 155                 160 
Ser His Thr Pro Asn Pro Ala Ser Tyr Met Val Pro Ser Ser Ala Ser
                165                 170                 175     
Thr Ser Val Asn Asn Pro Val Ser Gln Thr Pro Ser Ser Gly Gln Val
            180                 185                 190         
Ile Gln Lys Glu Thr Val Gly Gly Thr Thr Tyr Phe Tyr Thr Asp Thr
        195                 200                 205             
Thr Pro Ala Pro Leu Thr Gly Met Val Phe Pro Asn Tyr His Ile Tyr
    210                 215                 220                 
Pro Pro Thr Ala Pro His Val Ala Tyr Met Gln Pro Lys Ala Asn Ala
225                 230                 235                 240 
Pro Ser Phe Phe Met Ala Asp Glu Leu Arg Gln Glu Leu Ile Asn Arg
                245                 250                 255     
His Leu Ile Thr Met Ala Gln Ile Asp Gln Ala Asp Met Pro Ala Val
            260                 265                 270         
Pro Thr Glu Val Asp Ser Tyr His Ser Leu Phe Pro Leu Glu Pro Leu
        275                 280                 285             
Pro Pro Pro Asn Arg Ile Gln Lys Ser Ser Asn Phe Gly Tyr Ile Thr
    290                 295                 300                 
Ser Cys Tyr Lys Ala Val Asn Ser Lys Asp Asp Leu Pro Tyr Cys Leu
305                 310                 315                 320 
Arg Arg Ile His Gly Phe Arg Leu Val Asn Thr Lys Cys Met Val Leu
                325                 330                 335     
Val Asp Met Trp Lys Lys Ile Gln His Ser Asn Ile Val Thr Leu Arg
            340                 345                 350         
Glu Val Phe Thr Thr Lys Ala Phe Ala Glu Pro Ser Leu Val Phe Ala
        355                 360                 365             
Tyr Asp Phe His Ala Gly Gly Glu Thr Met Met Ser Arg His Phe Asn
    370                 375                 380                 
Asp Pro Asn Ala Asp Ala Tyr Phe Thr Lys Arg Lys Trp Gly Gln His
385                 390                 395                 400 
Glu Gly Pro Leu Pro Arg Gln His Ala Gly Leu Leu Pro Glu Ser Leu
                405                 410                 415     
Ile Trp Ala Tyr Ile Val Gln Leu Ser Ser Ala Leu Arg Thr Ile His
            420                 425                 430         
Thr Ala Gly Leu Ala Cys Arg Val Met Asp Pro Thr Lys Ile Leu Ile
        435                 440                 445             
Thr Gly Lys Thr Arg Leu Arg Val Asn Cys Val Gly Val Phe Asp Val
    450                 455                 460                 
Leu Thr Phe Asp Asn Ser Gln Asn Asn Asn Pro Leu Ala Leu Met Ala
465                 470                 475                 480 
Gln Tyr Gln Gln Ala Asp Leu Ile Ser Leu Gly Lys Val Val Leu Ala
                485                 490                 495     
Leu Ala Cys Asn Ser Leu Ala Gly Ile Gln Arg Glu Asn Leu Gln Lys
            500                 505                 510         
Ala Met Glu Leu Val Thr Ile Asn Tyr Ser Ser Asp Leu Lys Asn Leu
        515                 520                 525             
Ile Leu Tyr Leu Leu Thr Asp Gln Asn Arg Met Arg Ser Val Asn Asp
    530                 535                 540                 
Ile Met Pro Met Ile Gly Ala Arg Phe Tyr Thr Gln Leu Asp Ala Ala
545                 550                 555                 560 
Gln Met Arg Asn Asp Val Ile Glu Glu Asp Leu Ala Lys Glu Val Gln
                565                 570                 575     
Asn Gly Arg Leu Phe Arg Leu Leu Ala Lys Leu Gly Thr Ile Asn Glu
            580                 585                 590         
Arg Pro Glu Phe Gln Lys Asp Pro Thr Trp Ser Glu Thr Gly Asp Arg
        595                 600                 605             
Tyr Leu Leu Lys Leu Phe Arg Asp His Leu Phe His Gln Val Thr Glu
    610                 615                 620                 
Ala Gly Ala Pro Trp Ile Asp Leu Ser His Ile Ile Ser Cys Leu Asn
625                 630                 635                 640 
Lys Leu Asp Ala Gly Val Pro Glu Lys Ile Ser Leu Ile Ser Arg Asp
                645                 650                 655     
Glu Lys Ser Val Leu Val Val Thr Tyr Ser Asp Leu Lys Arg Cys Phe
            660                 665                 670         
Glu Asn Thr Phe Gln Glu Leu Ile Ala Ala Ala Asn Gly Gln Leu
        675                 680                 685         


<210> 6694
<211> 1849
<212> PRT
<213> Homo sapiens

<400> 6694
Met Ala Val Ser Arg Leu Asp Arg Leu Phe Ile Leu Leu Asp Thr Gly
 1               5                  10                  15      
Thr Thr Pro Val Thr Arg Lys Ala Ala Ala Gln Gln Leu Gly Glu Val
            20                  25                  30          
Val Lys Leu His Pro His Glu Leu Asn Asn Leu Leu Ser Lys Val Leu
        35                  40                  45              
Ile Tyr Leu Arg Ser Ala Asn Trp Asp Thr Arg Ile Ala Ala Gly Gln
    50                  55                  60                  
Ala Val Glu Ala Ile Val Lys Asn Val Pro Glu Trp Asn Pro Val Pro
65                  70                  75                  80  
Arg Thr Arg Gln Glu Pro Thr Ser Glu Ser Ser Met Glu Asp Ser Pro
                85                  90                  95      
Thr Thr Glu Arg Leu Asn Phe Asp Arg Phe Asp Ile Cys Arg Leu Leu
            100                 105                 110         
Gln His Gly Ala Ser Leu Leu Gly Ser Ala Gly Ala Glu Phe Glu Val
        115                 120                 125             
Gln Asp Glu Lys Ser Gly Glu Val Asp Pro Lys Glu Arg Ile Ala Arg
    130                 135                 140                 
Gln Arg Lys Leu Leu Gln Lys Lys Leu Gly Leu Asn Met Gly Glu Ala
145                 150                 155                 160 
Ile Gly Met Ser Thr Glu Glu Leu Phe Asn Asp Glu Asp Leu Asp Tyr
                165                 170                 175     
Thr Pro Thr Ser Ala Ser Phe Val Asn Lys Gln Pro Thr Leu Gln Ala
            180                 185                 190         
Ala Glu Leu Ile Asp Ser Glu Phe Arg Ala Gly Met Ser Asn Arg Gln
        195                 200                 205             
Lys Asn Lys Ala Lys Arg Met Ala Lys Leu Phe Ala Lys Gln Arg Ser
    210                 215                 220                 
Arg Asp Ala Val Glu Thr Asn Glu Lys Ser Asn Asp Ser Thr Asp Gly
225                 230                 235                 240 
Glu Pro Glu Glu Lys Arg Arg Lys Ile Ala Asn Val Val Ile Asn Gln
                245                 250                 255     
Ser Ala Asn Asp Ser Lys Val Leu Ile Asp Asn Ile Pro Asp Ser Ser
            260                 265                 270         
Ser Leu Ile Glu Glu Thr Asn Glu Trp Pro Leu Glu Ser Phe Cys Glu
        275                 280                 285             
Glu Leu Cys Asn Asp Leu Phe Asn Pro Ser Trp Glu Val Arg His Gly
    290                 295                 300                 
Ala Gly Thr Gly Leu Arg Glu Ile Leu Lys Ala His Gly Lys Ser Gly
305                 310                 315                 320 
Gly Lys Met Gly Asp Ser Thr Leu Glu Glu Met Ile Gln Gln His Gln
                325                 330                 335     
Glu Trp Leu Glu Asp Leu Val Ile Arg Leu Leu Cys Val Phe Ala Leu
            340                 345                 350         
Asp Arg Phe Gly Asp Phe Val Ser Asp Glu Val Val Ala Pro Val Arg
        355                 360                 365             
Glu Thr Cys Ala Gln Thr Leu Gly Val Val Leu Lys His Met Asn Glu
    370                 375                 380                 
Thr Gly Val His Lys Thr Val Asp Val Leu Leu Lys Leu Leu Thr Gln
385                 390                 395                 400 
Glu Gln Trp Glu Val Arg His Gly Gly Leu Leu Gly Ile Lys Tyr Ala
                405                 410                 415     
Leu Ala Val Arg Gln Asp Val Ile Asn Thr Leu Leu Pro Lys Val Leu
            420                 425                 430         
Thr Arg Ile Ile Glu Gly Leu Gln Asp Leu Asp Asp Asp Val Arg Ala
        435                 440                 445             
Val Ala Ala Ala Ser Leu Val Pro Val Val Glu Ser Leu Val Tyr Leu
    450                 455                 460                 
Gln Thr Gln Lys Val Pro Phe Ile Ile Asn Thr Leu Trp Asp Ala Leu
465                 470                 475                 480 
Leu Glu Leu Asp Asp Leu Thr Ala Ser Thr Asn Ser Ile Met Thr Leu
                485                 490                 495     
Leu Ser Ser Leu Leu Thr Tyr Pro Gln Val Gln Gln Cys Ser Ile Gln
            500                 505                 510         
Gln Ser Leu Thr Val Leu Val Pro Arg Val Trp Pro Phe Leu His His
        515                 520                 525             
Thr Ile Ser Ser Val Arg Arg Ala Ala Leu Glu Thr Leu Phe Thr Leu
    530                 535                 540                 
Leu Ser Thr Gln Asp Gln Asn Ser Ser Ser Trp Leu Ile Pro Ile Leu
545                 550                 555                 560 
Pro Asp Met Leu Arg His Ile Phe Gln Phe Cys Val Leu Glu Ser Ser
                565                 570                 575     
Gln Glu Ile Leu Asp Leu Ile His Lys Val Trp Met Glu Leu Leu Ser
            580                 585                 590         
Lys Ala Ser Val Gln Tyr Val Val Ala Ala Ala Cys Pro Trp Met Gly
        595                 600                 605             
Ala Trp Leu Cys Leu Met Met Gln Pro Ser His Leu Pro Ile Asp Leu
    610                 615                 620                 
Asn Met Leu Leu Glu Val Lys Ala Arg Ala Lys Glu Lys Thr Gly Gly
625                 630                 635                 640 
Lys Val Arg Gln Gly Gln Ser Gln Asn Lys Glu Val Leu Gln Glu Tyr
                645                 650                 655     
Ile Ala Gly Ala Asp Thr Ile Met Glu Asp Pro Ala Thr Arg Asp Phe
            660                 665                 670         
Val Val Met Arg Ala Arg Met Met Ala Ala Lys Leu Leu Gly Ala Leu
        675                 680                 685             
Cys Cys Cys Ile Cys Asp Pro Gly Val Asn Val Val Thr Gln Glu Ile
    690                 695                 700                 
Lys Pro Ala Glu Ser Leu Gly Gln Leu Leu Leu Phe His Leu Asn Ser
705                 710                 715                 720 
Lys Ser Ala Leu Gln Arg Ile Ser Val Ala Leu Val Ile Cys Glu Trp
                725                 730                 735     
Ala Ala Leu Gln Lys Glu Cys Lys Ala Val Thr Leu Ala Val Gln Pro
            740                 745                 750         
Arg Leu Leu Asp Ile Leu Ser Glu His Leu Tyr Tyr Asp Glu Ile Ala
        755                 760                 765             
Val Pro Phe Thr Arg Met Gln Asn Glu Cys Lys Gln Leu Ile Ser Ser
    770                 775                 780                 
Leu Ala Asp Val His Ile Glu Val Gly Asn Arg Val Asn Asn Asn Val
785                 790                 795                 800 
Leu Thr Ile Asp Gln Ala Ser Asp Leu Val Thr Thr Val Phe Asn Glu
                805                 810                 815     
Ala Thr Ser Ser Phe Asp Leu Asn Pro Gln Val Leu Gln Gln Leu Asp
            820                 825                 830         
Ser Lys Arg Gln Gln Val Gln Met Thr Val Thr Glu Thr Asn Gln Glu
        835                 840                 845             
Trp Gln Val Leu Gln Leu Arg Val His Thr Phe Ala Ala Cys Ala Val
    850                 855                 860                 
Val Ser Leu Gln Gln Leu Pro Glu Lys Leu Asn Pro Ile Ile Lys Pro
865                 870                 875                 880 
Leu Met Glu Thr Ile Lys Lys Glu Glu Asn Thr Leu Val Gln Asn Tyr
                885                 890                 895     
Ala Ala Gln Cys Ile Ala Lys Leu Leu Gln Gln Cys Thr Thr Arg Thr
            900                 905                 910         
Pro Cys Pro Asn Ser Lys Ile Ile Lys Asn Leu Cys Ser Ser Leu Cys
        915                 920                 925             
Val Asp Pro Tyr Leu Thr Pro Cys Val Thr Cys Pro Val Pro Thr Gln
    930                 935                 940                 
Ser Gly Gln Glu Asn Ser Lys Gly Ser Thr Ser Glu Lys Asp Gly Met
945                 950                 955                 960 
His His Thr Val Thr Lys His Arg Gly Ile Ile Thr Leu Tyr Arg His
                965                 970                 975     
Gln Lys Ala Ala Phe Ala Ile Thr Ser Arg Arg Gly Pro Thr Pro Lys
            980                 985                 990         
Ala Val Lys Ala Gln Ile Ala Asp Leu Pro Ala Gly Ser Ser Gly Asn
        995                 1000                1005            
Ile Leu Val Glu Leu Asp Glu Ala Gln Lys Pro Tyr Leu Val Gln Arg
    1010                1015                1020                
Arg Gly Ala Glu Phe Ala Leu Thr Thr Ile Val Lys His Phe Gly Gly
1025                1030                1035                1040
Glu Met Ala Val Lys Leu Pro His Leu Trp Asp Ala Met Val Gly Pro
                1045                1050                1055    
Leu Arg Asn Thr Ile Asp Ile Asn Asn Phe Asp Gly Lys Ser Leu Leu
            1060                1065                1070        
Asp Lys Gly Asp Ser Pro Ala Gln Glu Leu Val Asn Ser Leu Gln Val
        1075                1080                1085            
Phe Glu Thr Ala Ala Ala Ser Met Asp Ser Glu Leu His Pro Leu Leu
    1090                1095                1100                
Val Gln His Leu Pro His Leu Tyr Met Cys Leu Gln Tyr Pro Ser Thr
1105                1110                1115                1120
Ala Val Arg His Met Ala Ala Arg Cys Val Gly Val Met Ser Lys Ile
                1125                1130                1135    
Ala Thr Met Glu Thr Met Asn Ile Phe Leu Glu Lys Val Leu Pro Trp
            1140                1145                1150        
Leu Gly Ala Ile Asp Asp Ser Val Lys Gln Glu Gly Ala Ile Glu Ala
        1155                1160                1165            
Leu Ala Cys Val Met Glu Gln Leu Asp Val Gly Ile Val Pro Tyr Ile
    1170                1175                1180                
Val Leu Leu Val Val Pro Val Leu Gly Arg Met Ser Asp Gln Thr Asp
1185                1190                1195                1200
Ser Val Arg Phe Met Ala Thr Gln Cys Phe Ala Thr Leu Ile Arg Leu
                1205                1210                1215    
Met Pro Leu Glu Ala Gly Ile Pro Asp Pro Pro Asn Met Ser Ala Glu
            1220                1225                1230        
Leu Ile Gln Leu Lys Ala Lys Glu Arg His Phe Leu Glu Gln Leu Leu
        1235                1240                1245            
Asp Gly Lys Lys Leu Glu Asn Tyr Lys Ile Pro Val Pro Ile Asn Ala
    1250                1255                1260                
Glu Leu Arg Lys Tyr Gln Gln Asp Gly Val Asn Trp Leu Ala Phe Leu
1265                1270                1275                1280
Asn Lys Tyr Lys Leu His Gly Ile Leu Cys Asp Asp Met Gly Leu Gly
                1285                1290                1295    
Lys Thr Leu Gln Ser Ile Cys Ile Leu Ala Gly Asp His Cys His Arg
            1300                1305                1310        
Ala Gln Glu Tyr Ala Arg Ser Lys Leu Ala Glu Cys Met Pro Leu Pro
        1315                1320                1325            
Ser Leu Val Val Cys Pro Pro Thr Leu Thr Gly His Trp Val Asp Glu
    1330                1335                1340                
Val Gly Lys Phe Cys Ser Arg Glu Tyr Leu Asn Pro Leu His Tyr Thr
1345                1350                1355                1360
Gly Pro Pro Thr Glu Arg Ile Arg Leu Gln His Gln Val Lys Arg His
                1365                1370                1375    
Asn Leu Ile Val Ala Ser Tyr Asp Val Val Arg Asn Asp Ile Asp Phe
            1380                1385                1390        
Phe Arg Asn Ile Lys Phe Asn Tyr Cys Ile Leu Asp Glu Gly His Val
        1395                1400                1405            
Ile Lys Asn Gly Lys Thr Lys Leu Ser Lys Ala Val Lys Gln Leu Thr
    1410                1415                1420                
Ala Asn Tyr Arg Ile Ile Leu Ser Gly Thr Pro Ile Gln Asn Asn Val
1425                1430                1435                1440
Leu Glu Leu Trp Ser Leu Phe Asp Phe Leu Met Pro Gly Phe Leu Gly
                1445                1450                1455    
Thr Glu Arg Gln Phe Ala Ala Arg Tyr Gly Lys Pro Ile Leu Ala Ser
            1460                1465                1470        
Arg Asp Ala Arg Ser Ser Ser Arg Glu Gln Glu Ala Gly Val Leu Ala
        1475                1480                1485            
Met Asp Ala Leu His Arg Gln Val Leu Pro Phe Leu Leu Arg Arg Met
    1490                1495                1500                
Lys Glu Asp Val Leu Gln Asp Leu Pro Pro Lys Ile Ile Gln Asp Tyr
1505                1510                1515                1520
Tyr Cys Thr Leu Ser Pro Leu Gln Val Gln Leu Tyr Glu Asp Phe Ala
                1525                1530                1535    
Lys Ser Arg Ala Lys Cys Asp Val Asp Glu Thr Val Ser Ser Ala Thr
            1540                1545                1550        
Leu Ser Glu Glu Thr Glu Lys Pro Lys Leu Lys Ala Thr Gly His Val
        1555                1560                1565            
Phe Gln Ala Leu Gln Tyr Leu Arg Lys Leu Cys Asn His Pro Ala Leu
    1570                1575                1580                
Val Leu Thr Pro Gln His Pro Glu Phe Lys Thr Thr Ala Glu Lys Leu
1585                1590                1595                1600
Ala Val Gln Asn Ser Ser Leu His Asp Ile Gln His Ala Pro Lys Leu
                1605                1610                1615    
Ser Ala Leu Lys Gln Leu Leu Leu Asp Cys Gly Leu Gly Asn Gly Ser
            1620                1625                1630        
Thr Ser Glu Ser Gly Thr Glu Ser Val Val Ala Gln His Arg Ile Leu
        1635                1640                1645            
Ile Phe Cys Gln Leu Lys Ser Met Leu Asp Ile Val Glu His Asp Leu
    1650                1655                1660                
Leu Lys Pro His Leu Pro Ser Val Thr Tyr Leu Arg Leu Asp Gly Ser
1665                1670                1675                1680
Ile Pro Pro Gly Gln Arg His Ser Ile Val Ser Arg Phe Asn Asn Asp
                1685                1690                1695    
Pro Ser Ile Asp Val Leu Leu Leu Thr Thr His Val Gly Gly Leu Gly
            1700                1705                1710        
Leu Asn Leu Thr Gly Ala Asp Thr Val Val Phe Val Glu His Asp Trp
        1715                1720                1725            
Asn Pro Met Arg Asp Leu Gln Ala Met Asp Arg Ala His Arg Ile Gly
    1730                1735                1740                
Gln Lys Arg Val Val Asn Val Tyr Arg Leu Ile Thr Arg Gly Thr Leu
1745                1750                1755                1760
Glu Glu Lys Ile Met Gly Leu Gln Lys Phe Lys Met Asn Ile Ala Asn
                1765                1770                1775    
Thr Val Ile Ser Gln Glu Asn Ser Ser Leu Gln Ser Met Gly Thr Asp
            1780                1785                1790        
Gln Leu Leu Asp Leu Phe Thr Leu Asp Lys Asp Gly Lys Ala Glu Lys
        1795                1800                1805            
Ala Asp Thr Ser Thr Ser Gly Lys Ala Ser Met Lys Ser Ile Leu Glu
    1810                1815                1820                
Asn Leu Ser Asp Leu Trp Asp Gln Glu Gln Tyr Asp Ser Glu Tyr Ser
1825                1830                1835                1840
Leu Glu Asn Phe Met His Ser Leu Lys
                1845                


<210> 6695
<211> 625
<212> PRT
<213> Homo sapiens

<400> 6695
Met Asn Val Thr Ser Ile Ala Leu Arg Ala Gly Thr Trp Leu Leu Ala
 1               5                  10                  15      
Ala Trp His Val Lys Val Pro Pro Met Trp Leu Glu Ala Cys Ile Asn
            20                  25                  30          
Trp Ile Gln Glu Glu Asn Asn Asn Val Asn Leu Ser Gln Ala Gln Met
        35                  40                  45              
Asn Lys Gln Val Phe Glu Gln Trp Leu Leu Thr Asp Leu Arg Asp Leu
    50                  55                  60                  
Glu His Pro Leu Leu Pro Asp Gly Ile Leu Glu Ile Pro Lys Gly Glu
65                  70                  75                  80  
Leu Asn Gly Phe Tyr Ala Leu Gln Ile Asn Ser Leu Val Asp Val Ser
                85                  90                  95      
Gln Pro Ala Tyr Ser Gln Ile Gln Lys Leu Arg Gly Lys Asn Thr Thr
            100                 105                 110         
Asn Asp Leu Val Thr Ala Glu Ala Gln Val Thr Pro Lys Pro Trp Glu
        115                 120                 125             
Ala Lys Pro Ser Arg Met Leu Met Leu Gln Leu Thr Asp Gly Ile Val
    130                 135                 140                 
Gln Ile Gln Gly Met Glu Tyr Gln Pro Ile Pro Ile Leu His Ser Asp
145                 150                 155                 160 
Leu Pro Pro Gly Thr Lys Ile Leu Ile Tyr Gly Asn Ile Ser Phe Arg
                165                 170                 175     
Leu Gly Val Leu Leu Leu Lys Pro Glu Asn Val Lys Val Leu Gly Gly
            180                 185                 190         
Glu Val Asp Ala Leu Leu Glu Glu Tyr Ala Gln Glu Lys Val Leu Ala
        195                 200                 205             
Arg Leu Ile Gly Glu Pro Asp Leu Val Val Ser Val Ile Pro Asn Asn
    210                 215                 220                 
Ser Asn Glu Asn Ile Pro Arg Val Thr Asp Val Leu Asp Pro Ala Leu
225                 230                 235                 240 
Gly Pro Ser Asp Glu Glu Leu Leu Ala Ser Leu Asp Glu Asn Asp Glu
                245                 250                 255     
Leu Thr Thr Asn Asn Asp Thr Ser Ser Glu Arg Cys Phe Thr Thr Gly
            260                 265                 270         
Ser Ser Ser Asn Thr Ile Pro Thr Arg Gln Ser Ser Phe Glu Pro Glu
        275                 280                 285             
Phe Val Ile Ser Pro Arg Pro Lys Glu Glu Pro Ser Asn Leu Ser Ile
    290                 295                 300                 
His Val Met Asp Gly Glu Leu Asp Asp Phe Ser Leu Glu Glu Ala Leu
305                 310                 315                 320 
Leu Leu Glu Glu Thr Val Gln Lys Glu Gln Met Glu Thr Lys Glu Leu
                325                 330                 335     
Gln Pro Leu Thr Phe Asn Arg Asn Ala Asp Arg Ser Ile Glu Arg Phe
            340                 345                 350         
Ser His Asn Pro Asn Thr Thr Asn Asn Phe Ser Leu Thr Cys Lys Asn
        355                 360                 365             
Gly Asn Asn Asn Trp Ser Glu Lys Asn Val Ser Glu Gln Met Thr Asn
    370                 375                 380                 
Glu Asp Lys Ser Phe Gly Cys Pro Ser Val Arg Asp Gln Asn Arg Ser
385                 390                 395                 400 
Ile Phe Ser Val His Cys Asn Val Pro Leu Ala His Asp Phe Thr Asn
                405                 410                 415     
Lys Glu Lys Asn Leu Glu Thr Asp Asn Lys Ile Lys Gln Thr Ser Ser
            420                 425                 430         
Ser Asp Ser His Ser Leu Asn Asn Lys Ile Leu Asn Arg Glu Val Val
        435                 440                 445             
Asn Tyr Val Gln Lys Arg Ser Ser Gln Ile Ser Asn Glu Asn Asp Cys
    450                 455                 460                 
Asn Leu Gln Ser Cys Ser Leu Arg Ser Ser Glu Asn Ser Ile Asn Leu
465                 470                 475                 480 
Ser Ile Ala Met Asp Leu Tyr Ser Pro Pro Phe Val Tyr Leu Ser Val
                485                 490                 495     
Leu Met Ala Ser Lys Pro Lys Glu Val Thr Thr Val Lys Val Lys Ala
            500                 505                 510         
Phe Ile Val Thr Leu Thr Gly Asn Leu Ser Ser Ser Gly Gly Ile Trp
        515                 520                 525             
Ser Ile Thr Ala Lys Val Ser Asp Gly Thr Ala Tyr Leu Asp Val Asp
    530                 535                 540                 
Phe Val Asp Glu Ile Leu Thr Ser Leu Ile Gly Phe Ser Val Pro Glu
545                 550                 555                 560 
Met Lys Gln Ser Lys Lys Asp Pro Leu Gln Tyr Gln Lys Phe Leu Glu
                565                 570                 575     
Gly Leu Gln Lys Cys Gln Arg Asp Leu Ile Asp Leu Cys Cys Leu Met
            580                 585                 590         
Thr Ile Ser Phe Asn Pro Ser Leu Ser Lys Ala Met Val Leu Ala Leu
        595                 600                 605             
Gln Asp Val Asn Met Glu His Leu Glu Asn Leu Lys Lys Arg Leu Asn
    610                 615                 620                 
Lys
625 


<210> 6696
<211> 1205
<212> PRT
<213> Homo sapiens

<400> 6696
Glu Ala Ala Ala Ser Leu Arg Pro Ala Pro Pro Ala Ser Ser Leu Ala
 1               5                  10                  15      
Pro Gly Ser Ser Arg Arg Leu Leu Pro Pro His Gly Ser Ser Arg Arg
            20                  25                  30          
Ser Pro Gly Ser Leu Leu Pro Gln Leu Arg Leu Gly Gly Gly Gly Gln
        35                  40                  45              
Leu Gln Trp Cys Arg Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr
    50                  55                  60                  
Glu Pro Ser Pro Asp Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala
65                  70                  75                  80  
Thr Leu Glu Ala Glu Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly
                85                  90                  95      
Lys Thr Asp Tyr Ile Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn
            100                 105                 110         
Ser Glu Ser Lys Lys Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp
        115                 120                 125             
Thr Pro Ser Ser Lys Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val
    130                 135                 140                 
Glu Gly Ser Asp Thr Thr Gly Ser Pro Thr Glu Phe Leu Glu Glu Lys
145                 150                 155                 160 
Met Ala Tyr Gln Glu Tyr Pro Asn Ser Gln Asn Trp Pro Glu Asp Thr
                165                 170                 175     
Asn Phe Cys Phe Gln Pro Glu Gln Val Val Asp Pro Ile Gln Thr Asp
            180                 185                 190         
Pro Phe Lys Met Tyr His Asp Asp Asp Leu Ala Asp Leu Val Phe Pro
        195                 200                 205             
Ser Ser Ala Thr Ala Asp Thr Ser Ile Phe Ala Gly Gln Asn Asp Pro
    210                 215                 220                 
Leu Lys Asp Ser Tyr Gly Met Ser Pro Cys Asn Thr Ala Val Val Pro
225                 230                 235                 240 
Gln Gly Trp Ser Val Glu Ala Leu Asn Ser Pro His Ser Glu Ser Phe
                245                 250                 255     
Val Ser Pro Glu Ala Val Ala Glu Pro Pro Gln Pro Thr Ala Val Pro
            260                 265                 270         
Leu Glu Leu Ala Lys Glu Ile Glu Met Ala Ser Glu Glu Arg Pro Pro
        275                 280                 285             
Ala Gln Ala Leu Glu Ile Met Met Gly Leu Lys Thr Thr Asp Met Ala
    290                 295                 300                 
Pro Ser Lys Glu Thr Glu Met Ala Leu Ala Lys Asp Met Ala Leu Ala
305                 310                 315                 320 
Thr Lys Thr Glu Val Ala Leu Ala Lys Asp Met Glu Ser Pro Thr Lys
                325                 330                 335     
Leu Asp Val Thr Leu Ala Lys Asp Met Gln Pro Ser Met Glu Ser Asp
            340                 345                 350         
Met Ala Leu Val Lys Asp Met Glu Leu Pro Thr Glu Lys Glu Val Ala
        355                 360                 365             
Leu Val Lys Asp Val Arg Trp Pro Thr Glu Thr Asp Val Ser Ser Ala
    370                 375                 380                 
Lys Asn Val Val Leu Pro Thr Glu Thr Glu Val Ala Pro Ala Lys Asp
385                 390                 395                 400 
Val Thr Leu Leu Lys Glu Thr Glu Arg Ala Ser Pro Ile Lys Met Asp
                405                 410                 415     
Leu Ala Pro Ser Lys Asp Met Gly Pro Pro Lys Glu Asn Lys Lys Glu
            420                 425                 430         
Thr Glu Arg Ala Ser Pro Ile Lys Met Asp Leu Ala Pro Ser Lys Asp
        435                 440                 445             
Met Gly Pro Pro Lys Glu Asn Lys Ile Val Pro Ala Lys Asp Leu Val
    450                 455                 460                 
Leu Leu Ser Glu Ile Glu Val Ala Gln Ala Asn Asp Ile Ile Ser Ser
465                 470                 475                 480 
Thr Glu Ile Ser Ser Ala Glu Lys Val Ala Leu Ser Ser Glu Thr Glu
                485                 490                 495     
Val Ala Leu Ala Arg Asp Met Thr Leu Pro Pro Glu Thr Asn Val Ile
            500                 505                 510         
Leu Thr Lys Asp Lys Ala Leu Pro Leu Glu Ala Glu Val Ala Pro Val
        515                 520                 525             
Lys Asp Met Ala Gln Leu Pro Glu Thr Glu Ile Ala Pro Ala Lys Asp
    530                 535                 540                 
Val Ala Pro Ser Thr Val Lys Glu Val Gly Leu Leu Lys Asp Met Ser
545                 550                 555                 560 
Pro Leu Ser Glu Thr Glu Met Ala Leu Gly Lys Asp Val Thr Pro Pro
                565                 570                 575     
Pro Glu Thr Glu Val Val Leu Ile Lys Asn Val Cys Leu Pro Pro Glu
            580                 585                 590         
Met Glu Val Ala Leu Thr Glu Asp Gln Val Pro Ala Leu Lys Thr Glu
        595                 600                 605             
Ala Pro Leu Ala Lys Asp Gly Val Leu Thr Leu Ala Asn Asn Val Thr
    610                 615                 620                 
Pro Ala Lys Asp Val Pro Pro Leu Ser Glu Thr Glu Ala Thr Pro Val
625                 630                 635                 640 
Pro Ile Lys Asp Met Glu Ile Ala Gln Thr Gln Lys Gly Ile Ser Glu
                645                 650                 655     
Asp Ser His Leu Glu Ser Leu Gln Asp Val Gly Gln Ser Ala Ala Pro
            660                 665                 670         
Thr Phe Met Ile Ser Pro Glu Thr Val Thr Gly Thr Gly Lys Lys Cys
        675                 680                 685             
Ser Leu Pro Ala Glu Glu Asp Ser Val Leu Glu Lys Leu Gly Glu Arg
    690                 695                 700                 
Lys Pro Cys Asn Ser Gln Pro Ser Glu Leu Ser Ser Glu Thr Ser Gly
705                 710                 715                 720 
Ile Ala Arg Pro Glu Glu Gly Arg Pro Val Val Ser Gly Thr Gly Asn
                725                 730                 735     
Asp Ile Thr Thr Pro Pro Asn Lys Glu Leu Pro Pro Ser Pro Glu Lys
            740                 745                 750         
Lys Thr Lys Pro Leu Ala Thr Thr Gln Pro Ala Lys Thr Ser Thr Ser
        755                 760                 765             
Lys Ala Lys Thr Gln Pro Thr Ser Leu Pro Lys Gln Pro Ala Pro Thr
    770                 775                 780                 
Thr Ile Gly Gly Leu Asn Lys Lys Pro Met Ser Leu Ala Ser Gly Leu
785                 790                 795                 800 
Val Pro Ala Ala Pro Pro Lys Arg Pro Ala Val Ala Ser Ala Arg Pro
                805                 810                 815     
Ser Ile Leu Pro Ser Lys Asp Val Lys Pro Lys Pro Ile Ala Asp Ala
            820                 825                 830         
Lys Ala Pro Glu Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser Ala Pro
        835                 840                 845             
Ala Ser Arg Ser Gly Ser Lys Ser Thr Gln Thr Val Ala Lys Thr Thr
    850                 855                 860                 
Thr Ala Ala Ala Val Ala Ser Thr Gly Pro Ser Ser Arg Ser Pro Ser
865                 870                 875                 880 
Thr Leu Leu Pro Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly Lys Pro
                885                 890                 895     
Ala Glu Val Lys Lys Met Thr Ala Lys Ser Val Pro Ala Asp Leu Ser
            900                 905                 910         
Arg Pro Lys Ser Thr Ser Thr Ser Ser Met Lys Lys Thr Thr Thr Leu
        915                 920                 925             
Ser Gly Thr Ala Pro Ala Ala Gly Val Val Pro Ser Arg Val Lys Ala
    930                 935                 940                 
Thr Pro Met Pro Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp Lys Lys
945                 950                 955                 960 
Pro Thr Ser Ala Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu
                965                 970                 975     
Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val
            980                 985                 990         
Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg Ala Lys
        995                 1000                1005            
Val Glu Lys Lys Thr Glu Ala Ala Ala Thr Thr Arg Lys Pro Glu Ser
    1010                1015                1020                
Asn Ala Val Thr Lys Thr Ala Gly Pro Ile Ala Ser Ala Gln Lys Gln
1025                1030                1035                1040
Pro Ala Gly Lys Val Gln Ile Val Ser Lys Lys Val Ser Tyr Ser His
                1045                1050                1055    
Ile Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly
            1060                1065                1070        
Gly Gly Asn Val Gln Ile Gln Asn Lys Lys Val Asp Ile Ser Lys Val
        1075                1080                1085            
Ser Ser Lys Cys Gly Ser Lys Ala Asn Ile Lys His Lys Pro Gly Gly
    1090                1095                1100                
Gly Asp Val Lys Ile Glu Ser Gln Lys Leu Asn Phe Lys Glu Lys Ala
1105                1110                1115                1120
Gln Ala Lys Val Gly Ser Leu Asp Asn Val Gly His Leu Pro Ala Gly
                1125                1130                1135    
Gly Ala Val Lys Thr Glu Gly Gly Gly Ser Glu Ala Pro Leu Cys Pro
            1140                1145                1150        
Gly Pro Pro Ala Gly Glu Glu Pro Ala Ile Ser Glu Ala Ala Pro Glu
        1155                1160                1165            
Ala Gly Ala Pro Thr Ser Ala Ser Gly Leu Asn Gly His Pro Thr Leu
    1170                1175                1180                
Ser Gly Gly Gly Asp Gln Arg Glu Ala Gln Thr Leu Asp Ser Gln Ile
1185                1190                1195                1200
Gln Glu Thr Ser Ile
                1205


<210> 6697
<211> 1167
<212> PRT
<213> Homo sapiens

<400> 6697
Glu Ala Ala Ala Ser Leu Arg Pro Ala Pro Pro Ala Ser Ser Leu Ala
 1               5                  10                  15      
Pro Gly Ser Ser Arg Arg Leu Leu Pro Pro His Gly Ser Ser Arg Arg
            20                  25                  30          
Ser Pro Gly Ser Leu Leu Pro Gln Leu Arg Leu Gly Gly Gly Gly Gln
        35                  40                  45              
Leu Gln Trp Cys Arg Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr
    50                  55                  60                  
Glu Pro Ser Pro Asp Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala
65                  70                  75                  80  
Thr Leu Glu Ala Glu Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly
                85                  90                  95      
Lys Thr Asp Tyr Ile Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn
            100                 105                 110         
Ser Glu Ser Lys Lys Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp
        115                 120                 125             
Thr Pro Ser Ser Lys Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val
    130                 135                 140                 
Glu Gly Ser Asp Thr Thr Gly Ser Pro Thr Glu Phe Leu Glu Glu Lys
145                 150                 155                 160 
Met Ala Tyr Gln Glu Tyr Pro Asn Ser Gln Asn Trp Pro Glu Asp Thr
                165                 170                 175     
Asn Phe Cys Phe Gln Pro Glu Gln Val Val Asp Pro Ile Gln Thr Asp
            180                 185                 190         
Pro Phe Lys Met Tyr His Asp Asp Asp Leu Ala Asp Leu Val Phe Pro
        195                 200                 205             
Ser Ser Ala Thr Ala Asp Thr Ser Ile Phe Ala Gly Gln Asn Asp Pro
    210                 215                 220                 
Leu Lys Asp Ser Tyr Gly Met Ser Pro Cys Asn Thr Ala Val Val Pro
225                 230                 235                 240 
Gln Gly Trp Ser Val Glu Ala Leu Asn Ser Pro His Ser Glu Ser Phe
                245                 250                 255     
Val Ser Pro Glu Ala Val Ala Glu Pro Pro Gln Pro Thr Ala Val Pro
            260                 265                 270         
Leu Glu Leu Ala Lys Glu Ile Glu Met Ala Ser Glu Glu Arg Pro Pro
        275                 280                 285             
Ala Gln Ala Leu Glu Ile Met Met Gly Leu Lys Thr Thr Asp Met Ala
    290                 295                 300                 
Pro Ser Lys Glu Thr Glu Met Ala Leu Ala Lys Asp Met Ala Leu Ala
305                 310                 315                 320 
Thr Lys Thr Glu Val Ala Leu Ala Lys Asp Met Glu Ser Pro Thr Lys
                325                 330                 335     
Leu Asp Val Thr Leu Ala Lys Asp Met Gln Pro Ser Met Glu Ser Asp
            340                 345                 350         
Met Ala Leu Val Lys Asp Met Glu Leu Pro Thr Glu Lys Glu Val Ala
        355                 360                 365             
Leu Val Lys Asp Val Arg Trp Pro Thr Glu Thr Asp Val Ser Ser Ala
    370                 375                 380                 
Lys Asn Val Val Leu Pro Thr Glu Thr Glu Val Ala Pro Ala Lys Asp
385                 390                 395                 400 
Val Thr Leu Leu Lys Glu Thr Glu Arg Ala Ser Pro Ile Lys Met Asp
                405                 410                 415     
Leu Ala Pro Ser Lys Asp Met Gly Pro Pro Lys Glu Asn Lys Lys Glu
            420                 425                 430         
Thr Glu Arg Ala Ser Pro Ile Lys Met Asp Leu Ala Pro Ser Lys Asp
        435                 440                 445             
Met Gly Pro Pro Lys Glu Asn Lys Ile Val Pro Ala Lys Asp Leu Val
    450                 455                 460                 
Leu Leu Ser Glu Ile Glu Val Ala Gln Ala Asn Asp Ile Ile Ser Ser
465                 470                 475                 480 
Thr Glu Ile Ser Ser Ala Glu Lys Val Ala Leu Ser Ser Glu Thr Glu
                485                 490                 495     
Val Ala Leu Ala Arg Asp Met Thr Leu Pro Pro Glu Thr Asn Val Ile
            500                 505                 510         
Leu Thr Lys Asp Lys Ala Leu Pro Leu Glu Ala Glu Val Ala Pro Val
        515                 520                 525             
Lys Asp Met Ala Gln Leu Pro Glu Thr Glu Ile Ala Pro Ala Lys Asp
    530                 535                 540                 
Val Ala Pro Ser Thr Val Lys Glu Val Gly Leu Leu Lys Asp Met Ser
545                 550                 555                 560 
Pro Leu Ser Glu Thr Glu Met Ala Leu Gly Lys Asp Val Thr Pro Pro
                565                 570                 575     
Pro Glu Thr Glu Val Val Leu Ile Lys Asn Val Cys Leu Pro Pro Glu
            580                 585                 590         
Met Glu Val Ala Leu Thr Glu Asp Gln Val Pro Ala Leu Lys Thr Glu
        595                 600                 605             
Ala Pro Leu Ala Lys Asp Gly Val Leu Thr Leu Ala Asn Asn Val Thr
    610                 615                 620                 
Pro Ala Lys Asp Val Pro Pro Leu Ser Glu Thr Glu Ala Thr Pro Val
625                 630                 635                 640 
Pro Ile Lys Asp Met Glu Ile Ala Gln Thr Gln Lys Gly Ile Ser Glu
                645                 650                 655     
Asp Ser His Leu Glu Ser Leu Gln Asp Val Gly Gln Ser Ala Ala Pro
            660                 665                 670         
Thr Phe Met Ile Ser Pro Glu Thr Val Thr Gly Thr Gly Lys Lys Cys
        675                 680                 685             
Ser Leu Pro Ala Glu Glu Asp Ser Val Leu Glu Lys Leu Gly Glu Arg
    690                 695                 700                 
Lys Pro Cys Asn Ser Gln Pro Ser Glu Leu Ser Ser Glu Thr Ser Gly
705                 710                 715                 720 
Ile Ala Arg Pro Glu Glu Gly Arg Pro Val Val Ser Gly Thr Gly Asn
                725                 730                 735     
Asp Ile Thr Thr Pro Pro Asn Lys Glu Leu Pro Pro Ser Pro Glu Lys
            740                 745                 750         
Lys Thr Lys Pro Leu Ala Thr Thr Gln Pro Ala Lys Thr Ser Thr Ser
        755                 760                 765             
Lys Ala Lys Thr Gln Pro Thr Ser Leu Pro Lys Gln Pro Ala Pro Thr
    770                 775                 780                 
Thr Ile Gly Gly Leu Asn Lys Lys Pro Met Ser Leu Ala Ser Gly Leu
785                 790                 795                 800 
Val Pro Ala Ala Pro Pro Lys Arg Pro Ala Val Ala Ser Ala Arg Pro
                805                 810                 815     
Ser Ile Leu Pro Ser Lys Asp Val Lys Pro Lys Pro Ile Ala Asp Ala
            820                 825                 830         
Lys Ala Pro Glu Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser Ala Pro
        835                 840                 845             
Ala Ser Arg Ser Gly Ser Lys Ser Thr Gln Thr Val Ala Lys Thr Thr
    850                 855                 860                 
Thr Ala Ala Ala Val Ala Ser Thr Gly Pro Ser Ser Arg Ser Pro Ser
865                 870                 875                 880 
Thr Leu Leu Pro Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly Lys Pro
                885                 890                 895     
Ala Glu Val Lys Lys Met Thr Ala Lys Ser Val Pro Ala Asp Leu Ser
            900                 905                 910         
Arg Pro Lys Ser Thr Ser Thr Ser Ser Met Lys Lys Thr Thr Thr Leu
        915                 920                 925             
Ser Gly Thr Ala Pro Ala Ala Gly Val Val Pro Ser Arg Val Lys Ala
    930                 935                 940                 
Thr Pro Met Pro Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp Lys Lys
945                 950                 955                 960 
Pro Thr Ser Ala Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu
                965                 970                 975     
Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val
            980                 985                 990         
Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg Val Gln
        995                 1000                1005            
Ile Val Ser Lys Lys Val Ser Tyr Ser His Ile Gln Ser Lys Cys Gly
    1010                1015                1020                
Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Asn Val Gln Ile
1025                1030                1035                1040
Gln Asn Lys Lys Val Asp Ile Ser Lys Val Ser Ser Lys Cys Gly Ser
                1045                1050                1055    
Lys Ala Asn Ile Lys His Lys Pro Gly Gly Gly Asp Val Lys Ile Glu
            1060                1065                1070        
Ser Gln Lys Leu Asn Phe Lys Glu Lys Ala Gln Ala Lys Val Gly Ser
        1075                1080                1085            
Leu Asp Asn Val Gly His Leu Pro Ala Gly Gly Ala Val Lys Thr Glu
    1090                1095                1100                
Gly Gly Gly Ser Glu Ala Pro Leu Cys Pro Gly Pro Pro Ala Gly Glu
1105                1110                1115                1120
Glu Pro Ala Ile Ser Glu Ala Ala Pro Glu Ala Gly Ala Pro Thr Ser
                1125                1130                1135    
Ala Ser Gly Leu Asn Gly His Pro Thr Leu Ser Gly Gly Gly Asp Gln
            1140                1145                1150        
Arg Glu Ala Gln Thr Leu Asp Ser Gln Ile Gln Glu Thr Ser Ile
        1155                1160                1165        


<210> 6698
<211> 1135
<212> PRT
<213> Homo sapiens

<400> 6698
Glu Ala Ala Ala Ser Leu Arg Pro Ala Pro Pro Ala Ser Ser Leu Ala
 1               5                  10                  15      
Pro Gly Ser Ser Arg Arg Leu Leu Pro Pro His Gly Ser Ser Arg Arg
            20                  25                  30          
Ser Pro Gly Ser Leu Leu Pro Gln Leu Arg Leu Gly Gly Gly Gly Gln
        35                  40                  45              
Leu Gln Trp Cys Arg Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr
    50                  55                  60                  
Glu Pro Ser Pro Asp Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala
65                  70                  75                  80  
Thr Leu Glu Ala Glu Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly
                85                  90                  95      
Lys Thr Asp Tyr Ile Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn
            100                 105                 110         
Ser Glu Ser Lys Lys Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp
        115                 120                 125             
Thr Pro Ser Ser Lys Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val
    130                 135                 140                 
Glu Gly Ser Asp Thr Thr Gly Ser Pro Thr Glu Phe Leu Glu Glu Lys
145                 150                 155                 160 
Met Ala Tyr Gln Glu Tyr Pro Asn Ser Gln Asn Trp Pro Glu Asp Thr
                165                 170                 175     
Asn Phe Cys Phe Gln Pro Glu Gln Val Val Asp Pro Ile Gln Thr Asp
            180                 185                 190         
Pro Phe Lys Met Tyr His Asp Asp Asp Leu Ala Asp Leu Val Phe Pro
        195                 200                 205             
Ser Ser Ala Thr Ala Asp Thr Ser Ile Phe Ala Gly Gln Asn Asp Pro
    210                 215                 220                 
Leu Lys Asp Ser Tyr Gly Met Ser Pro Cys Asn Thr Ala Val Val Pro
225                 230                 235                 240 
Gln Gly Trp Ser Val Glu Ala Leu Asn Ser Pro His Ser Glu Ser Phe
                245                 250                 255     
Val Ser Pro Glu Ala Val Ala Glu Pro Pro Gln Pro Thr Ala Val Pro
            260                 265                 270         
Leu Glu Leu Ala Lys Glu Ile Glu Met Ala Ser Glu Glu Arg Pro Pro
        275                 280                 285             
Ala Gln Ala Leu Glu Ile Met Met Gly Leu Lys Thr Thr Asp Met Ala
    290                 295                 300                 
Pro Ser Lys Glu Thr Glu Met Ala Leu Ala Lys Asp Met Ala Leu Ala
305                 310                 315                 320 
Thr Lys Thr Glu Val Ala Leu Ala Lys Asp Met Glu Ser Pro Thr Lys
                325                 330                 335     
Leu Asp Val Thr Leu Ala Lys Asp Met Gln Pro Ser Met Glu Ser Asp
            340                 345                 350         
Met Ala Leu Val Lys Asp Met Glu Leu Pro Thr Glu Lys Glu Val Ala
        355                 360                 365             
Leu Val Lys Asp Val Arg Trp Pro Thr Glu Thr Asp Val Ser Ser Ala
    370                 375                 380                 
Lys Asn Val Val Leu Pro Thr Glu Thr Glu Val Ala Pro Ala Lys Asp
385                 390                 395                 400 
Val Thr Leu Leu Lys Glu Thr Glu Arg Ala Ser Pro Ile Lys Met Asp
                405                 410                 415     
Leu Ala Pro Ser Lys Asp Met Gly Pro Pro Lys Glu Asn Lys Lys Glu
            420                 425                 430         
Thr Glu Arg Ala Ser Pro Ile Lys Met Asp Leu Ala Pro Ser Lys Asp
        435                 440                 445             
Met Gly Pro Pro Lys Glu Asn Lys Ile Val Pro Ala Lys Asp Leu Val
    450                 455                 460                 
Leu Leu Ser Glu Ile Glu Val Ala Gln Ala Asn Asp Ile Ile Ser Ser
465                 470                 475                 480 
Thr Glu Ile Ser Ser Ala Glu Lys Val Ala Leu Ser Ser Glu Thr Glu
                485                 490                 495     
Val Ala Leu Ala Arg Asp Met Thr Leu Pro Pro Glu Thr Asn Val Ile
            500                 505                 510         
Leu Thr Lys Asp Lys Ala Leu Pro Leu Glu Ala Glu Val Ala Pro Val
        515                 520                 525             
Lys Asp Met Ala Gln Leu Pro Glu Thr Glu Ile Ala Pro Ala Lys Asp
    530                 535                 540                 
Val Ala Pro Ser Thr Val Lys Glu Val Gly Leu Leu Lys Asp Met Ser
545                 550                 555                 560 
Pro Leu Ser Glu Thr Glu Met Ala Leu Gly Lys Asp Val Thr Pro Pro
                565                 570                 575     
Pro Glu Thr Glu Val Val Leu Ile Lys Asn Val Cys Leu Pro Pro Glu
            580                 585                 590         
Met Glu Val Ala Leu Thr Glu Asp Gln Val Pro Ala Leu Lys Thr Glu
        595                 600                 605             
Ala Pro Leu Ala Lys Asp Gly Val Leu Thr Leu Ala Asn Asn Val Thr
    610                 615                 620                 
Pro Ala Lys Asp Val Pro Pro Leu Ser Glu Thr Glu Ala Thr Pro Val
625                 630                 635                 640 
Pro Ile Lys Asp Met Glu Ile Ala Gln Thr Gln Lys Gly Ile Ser Glu
                645                 650                 655     
Asp Ser His Leu Glu Ser Leu Gln Asp Val Gly Gln Ser Ala Ala Pro
            660                 665                 670         
Thr Phe Met Ile Ser Pro Glu Thr Val Thr Gly Thr Gly Lys Lys Cys
        675                 680                 685             
Ser Leu Pro Ala Glu Glu Asp Ser Val Leu Glu Lys Leu Gly Glu Arg
    690                 695                 700                 
Lys Pro Cys Asn Ser Gln Pro Ser Glu Leu Ser Ser Glu Thr Ser Gly
705                 710                 715                 720 
Ile Ala Arg Pro Glu Glu Gly Arg Pro Val Val Ser Gly Thr Gly Asn
                725                 730                 735     
Asp Ile Thr Thr Pro Pro Asn Lys Glu Leu Pro Pro Ser Pro Glu Lys
            740                 745                 750         
Lys Thr Lys Pro Leu Ala Thr Thr Gln Pro Ala Lys Thr Ser Thr Ser
        755                 760                 765             
Lys Ala Lys Thr Gln Pro Thr Ser Leu Pro Lys Gln Pro Ala Pro Thr
    770                 775                 780                 
Thr Ile Gly Gly Leu Asn Lys Lys Pro Met Ser Leu Ala Ser Gly Leu
785                 790                 795                 800 
Val Pro Ala Ala Pro Pro Lys Arg Pro Ala Val Ala Ser Ala Arg Pro
                805                 810                 815     
Ser Ile Leu Pro Ser Lys Asp Val Lys Pro Lys Pro Ile Ala Asp Ala
            820                 825                 830         
Lys Ala Pro Glu Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser Ala Pro
        835                 840                 845             
Ala Ser Arg Ser Gly Ser Lys Ser Thr Gln Thr Val Ala Lys Thr Thr
    850                 855                 860                 
Thr Ala Ala Ala Val Ala Ser Thr Gly Pro Ser Ser Arg Ser Pro Ser
865                 870                 875                 880 
Thr Leu Leu Pro Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly Lys Pro
                885                 890                 895     
Ala Glu Val Lys Lys Met Thr Ala Lys Ser Val Pro Ala Asp Leu Ser
            900                 905                 910         
Arg Pro Lys Ser Thr Ser Thr Ser Ser Met Lys Lys Thr Thr Thr Leu
        915                 920                 925             
Ser Gly Thr Ala Pro Ala Ala Gly Val Val Pro Ser Arg Val Lys Ala
    930                 935                 940                 
Thr Pro Met Pro Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp Lys Lys
945                 950                 955                 960 
Pro Thr Ser Ala Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu
                965                 970                 975     
Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val
            980                 985                 990         
Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg Val Gln
        995                 1000                1005            
Ile Gln Asn Lys Lys Val Asp Ile Ser Lys Val Ser Ser Lys Cys Gly
    1010                1015                1020                
Ser Lys Ala Asn Ile Lys His Lys Pro Gly Gly Gly Asp Val Lys Ile
1025                1030                1035                1040
Glu Ser Gln Lys Leu Asn Phe Lys Glu Lys Ala Gln Ala Lys Val Gly
                1045                1050                1055    
Ser Leu Asp Asn Val Gly His Leu Pro Ala Gly Gly Ala Val Lys Thr
            1060                1065                1070        
Glu Gly Gly Gly Ser Glu Ala Pro Leu Cys Pro Gly Pro Pro Ala Gly
        1075                1080                1085            
Glu Glu Pro Ala Ile Ser Glu Ala Ala Pro Glu Ala Gly Ala Pro Thr
    1090                1095                1100                
Ser Ala Ser Gly Leu Asn Gly His Pro Thr Leu Ser Gly Gly Gly Asp
1105                1110                1115                1120
Gln Arg Glu Ala Gln Thr Leu Asp Ser Gln Ile Gln Glu Thr Asn
                1125                1130                1135


<210> 6699
<211> 187
<212> PRT
<213> Homo sapiens

<400> 6699
Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu Ala Thr Asn Thr Ser
 1               5                  10                  15      
Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val Gln Ile Val Ser Lys
            20                  25                  30          
Lys Val Ser Tyr Ser His Ile Gln Ser Lys Cys Gly Ser Lys Asp Asn
        35                  40                  45              
Ile Lys His Val Pro Gly Gly Gly Asn Val Gln Ile Gln Asn Lys Lys
    50                  55                  60                  
Val Asp Ile Ser Lys Val Ser Ser Lys Cys Gly Ser Lys Ala Asn Ile
65                  70                  75                  80  
Lys His Lys Pro Gly Gly Gly Asp Val Lys Ile Glu Ser Gln Lys Leu
                85                  90                  95      
Asn Phe Lys Glu Lys Ala Gln Ala Lys Val Gly Ser Leu Asp Asn Val
            100                 105                 110         
Gly His Leu Pro Ala Gly Gly Ala Val Lys Thr Glu Gly Gly Gly Ser
        115                 120                 125             
Glu Ala Pro Leu Cys Pro Gly Pro Pro Ala Gly Glu Glu Pro Ala Ile
    130                 135                 140                 
Ser Glu Ala Ala Pro Glu Ala Gly Ala Pro Thr Ser Ala Ser Gly Leu
145                 150                 155                 160 
Asn Gly His Pro Thr Leu Ser Gly Gly Gly Asp Gln Arg Glu Ala Gln
                165                 170                 175     
Thr Leu Asp Ser Gln Ile Gln Glu Thr Ser Ile
            180                 185         


<210> 6700
<211> 979
<212> PRT
<213> Homo sapiens

<400> 6700
Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr Glu Pro Ser Pro Asp
 1               5                  10                  15      
Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala Thr Leu Glu Ala Glu
            20                  25                  30          
Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly Lys Thr Asp Tyr Ile
        35                  40                  45              
Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn Ser Glu Ser Lys Lys
    50                  55                  60                  
Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp Thr Pro Ser Ser Lys
65                  70                  75                  80  
Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val Glu Gly Ser Asp Thr
                85                  90                  95      
Thr Gly Ser Pro Thr Glu Phe Leu Glu Glu Lys Met Ala Tyr Gln Glu
            100                 105                 110         
Tyr Pro Asn Ser Gln Asn Trp Pro Glu Asp Thr Asn Phe Cys Phe Gln
        115                 120                 125             
Pro Glu Gln Val Val Asp Pro Ile Gln Thr Asp Pro Phe Lys Met Tyr
    130                 135                 140                 
His Asp Asp Asp Leu Ala Asp Leu Val Phe Pro Ser Ser Ala Thr Ala
145                 150                 155                 160 
Asp Thr Ser Ile Phe Ala Gly Gln Asn Asp Pro Leu Lys Asp Ser Tyr
                165                 170                 175     
Gly Met Ser Pro Cys Asn Thr Ala Val Val Pro Gln Gly Trp Ser Val
            180                 185                 190         
Glu Ala Leu Asn Ser Pro His Ser Glu Ser Phe Val Ser Pro Glu Ala
        195                 200                 205             
Val Ala Glu Pro Pro Gln Pro Thr Ala Val Pro Leu Glu Leu Ala Lys
    210                 215                 220                 
Glu Ile Glu Met Ala Ser Glu Glu Arg Pro Pro Ala Gln Ala Leu Glu
225                 230                 235                 240 
Ile Met Met Gly Leu Lys Thr Thr Asp Met Ala Pro Ser Lys Glu Thr
                245                 250                 255     
Glu Met Ala Leu Ala Lys Asp Met Ala Leu Ala Thr Lys Thr Glu Val
            260                 265                 270         
Ala Leu Ala Lys Asp Met Glu Ser Pro Thr Lys Leu Asp Val Thr Leu
        275                 280                 285             
Ala Lys Asp Met Gln Pro Ser Met Glu Ser Asp Met Ala Leu Val Lys
    290                 295                 300                 
Asp Met Glu Leu Pro Thr Glu Lys Glu Val Ala Leu Val Lys Asp Val
305                 310                 315                 320 
Arg Trp Pro Thr Glu Thr Asp Val Ser Ser Ala Lys Asn Val Val Leu
                325                 330                 335     
Pro Thr Glu Thr Glu Val Ala Pro Ala Lys Asp Val Thr Leu Leu Lys
            340                 345                 350         
Glu Thr Glu Arg Ala Ser Pro Ile Lys Met Asp Leu Ala Pro Ser Lys
        355                 360                 365             
Asp Met Gly Pro Pro Lys Glu Asn Lys Lys Glu Thr Glu Arg Ala Ser
    370                 375                 380                 
Pro Ile Lys Met Asp Leu Ala Pro Ser Lys Asp Met Gly Pro Pro Lys
385                 390                 395                 400 
Glu Asn Lys Ile Val Pro Ala Lys Asp Leu Val Leu Leu Ser Glu Ile
                405                 410                 415     
Glu Val Ala Gln Ala Asn Asp Ile Ile Ser Ser Thr Glu Ile Ser Ser
            420                 425                 430         
Ala Glu Lys Val Ala Leu Ser Ser Glu Thr Glu Val Ala Leu Ala Arg
        435                 440                 445             
Asp Met Thr Leu Pro Pro Glu Thr Asn Val Ile Leu Thr Lys Asp Lys
    450                 455                 460                 
Ala Leu Pro Leu Glu Ala Glu Val Ala Pro Val Lys Asp Met Ala Gln
465                 470                 475                 480 
Leu Pro Glu Thr Glu Ile Ala Pro Ala Lys Asp Val Ala Pro Ser Thr
                485                 490                 495     
Val Lys Glu Val Gly Leu Leu Lys Asp Met Ser Pro Leu Ser Glu Thr
            500                 505                 510         
Glu Met Ala Leu Gly Lys Asp Val Thr Pro Pro Pro Glu Thr Glu Val
        515                 520                 525             
Val Leu Ile Lys Asn Val Cys Leu Pro Pro Glu Met Glu Val Ala Leu
    530                 535                 540                 
Thr Glu Asp Gln Val Pro Ala Leu Lys Thr Glu Ala Pro Thr Thr Ile
545                 550                 555                 560 
Gly Gly Leu Asn Lys Lys Pro Met Ser Leu Ala Ser Gly Leu Val Pro
                565                 570                 575     
Ala Ala Pro Pro Lys Arg Pro Ala Val Ala Ser Ala Arg Pro Ser Ile
            580                 585                 590         
Leu Pro Ser Lys Asp Val Lys Pro Lys Pro Ile Ala Asp Ala Lys Ala
        595                 600                 605             
Pro Glu Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser Ala Pro Ala Ser
    610                 615                 620                 
Arg Ser Gly Ser Lys Ser Thr Gln Thr Val Ala Lys Thr Thr Thr Ala
625                 630                 635                 640 
Ala Ala Val Ala Ser Thr Gly Pro Ser Ser Arg Ser Pro Ser Thr Leu
                645                 650                 655     
Leu Pro Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly Lys Pro Ala Glu
            660                 665                 670         
Val Lys Lys Met Thr Ala Lys Ser Val Pro Ala Asp Leu Ser Arg Pro
        675                 680                 685             
Lys Ser Thr Ser Thr Ser Ser Met Lys Lys Thr Thr Thr Leu Ser Gly
    690                 695                 700                 
Thr Ala Pro Ala Ala Gly Val Val Pro Ser Arg Val Lys Ala Thr Pro
705                 710                 715                 720 
Met Pro Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp Lys Lys Pro Thr
                725                 730                 735     
Ser Ala Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser Arg Leu Ala Thr
            740                 745                 750         
Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser Lys Val Gly Ser
        755                 760                 765             
Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg Ala Lys Val Glu
    770                 775                 780                 
Lys Lys Thr Glu Ala Ala Ala Thr Thr Arg Lys Pro Glu Ser Asn Ala
785                 790                 795                 800 
Val Thr Lys Thr Ala Gly Pro Ile Ala Ser Ala Gln Lys Gln Pro Ala
                805                 810                 815     
Gly Lys Val Gln Ile Val Ser Lys Lys Val Ser Tyr Ser His Ile Gln
            820                 825                 830         
Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly
        835                 840                 845             
Asn Val Gln Ile Gln Asn Lys Lys Val Asp Ile Ser Lys Val Ser Ser
    850                 855                 860                 
Lys Cys Gly Ser Lys Ala Asn Ile Lys His Lys Pro Gly Gly Gly Asp
865                 870                 875                 880 
Val Lys Ile Glu Ser Gln Lys Leu Asn Phe Lys Glu Lys Ala Gln Ala
                885                 890                 895     
Lys Val Gly Ser Leu Asp Asn Val Gly His Leu Pro Ala Gly Gly Ala
            900                 905                 910         
Val Lys Thr Glu Gly Gly Gly Ser Glu Ala Pro Leu Cys Pro Gly Pro
        915                 920                 925             
Pro Ala Gly Glu Glu Pro Ala Ile Ser Glu Ala Ala Pro Glu Ala Gly
    930                 935                 940                 
Ala Pro Thr Ser Ala Ser Gly Leu Asn Gly His Pro Thr Leu Ser Gly
945                 950                 955                 960 
Gly Gly Asp Gln Arg Glu Ala Gln Thr Leu Asp Ser Gln Ile Gln Glu
                965                 970                 975     
Thr Ser Ile
            


<210> 6701
<211> 1041
<212> PRT
<213> Homo sapiens

<400> 6701
Met Ala Asp Leu Ser Leu Ala Asp Ala Leu Thr Glu Pro Ser Pro Asp
 1               5                  10                  15      
Ile Glu Gly Glu Ile Lys Arg Asp Phe Ile Ala Thr Leu Glu Ala Glu
            20                  25                  30          
Ala Phe Asp Asp Val Val Gly Glu Thr Val Gly Lys Thr Asp Tyr Ile
        35                  40                  45              
Pro Leu Leu Asp Val Asp Glu Lys Thr Gly Asn Ser Glu Ser Lys Lys
    50                  55                  60                  
Lys Pro Cys Ser Glu Thr Ser Gln Ile Glu Asp Thr Pro Ser Ser Lys
65                  70                  75                  80  
Pro Thr Leu Leu Ala Asn Gly Gly His Gly Val Glu Gly Ser Asp Thr
                85                  90                  95      
Thr Gly Ser Pro Thr Glu Phe Leu Glu Glu Lys Met Ala Tyr Gln Glu
            100                 105                 110         
Tyr Pro Asn Ser Gln Asn Trp Pro Glu Asp Thr Asn Phe Cys Phe Gln
        115                 120                 125             
Pro Glu Gln Val Val Asp Pro Ile Gln Thr Asp Pro Phe Lys Met Tyr
    130                 135                 140                 
His Asp Asp Asp Leu Ala Asp Leu Val Phe Pro Ser Ser Ala Thr Ala
145                 150                 155                 160 
Asp Thr Ser Ile Phe Ala Gly Gln Asn Asp Pro Leu Lys Asp Ser Tyr
                165                 170                 175     
Val Pro Leu Glu Leu Ala Lys Glu Ile Glu Met Ala Ser Glu Glu Arg
            180                 185                 190         
Pro Pro Ala Gln Ala Leu Glu Ile Met Met Gly Leu Lys Thr Thr Asp
        195                 200                 205             
Met Ala Pro Ser Lys Glu Thr Glu Met Ala Leu Ala Lys Asp Met Ala
    210                 215                 220                 
Leu Ala Thr Lys Thr Glu Val Ala Leu Ala Lys Asp Met Glu Ser Pro
225                 230                 235                 240 
Thr Lys Leu Asp Val Thr Leu Ala Lys Asp Met Gln Pro Ser Met Glu
                245                 250                 255     
Ser Asp Met Ala Leu Val Lys Asp Met Glu Leu Pro Thr Glu Lys Glu
            260                 265                 270         
Val Ala Leu Val Lys Asp Val Arg Trp Pro Thr Glu Thr Asp Val Ser
        275                 280                 285             
Ser Ala Lys Asn Val Val Leu Pro Thr Glu Thr Glu Val Ala Pro Ala
    290                 295                 300                 
Lys Asp Val Thr Leu Leu Lys Glu Thr Glu Arg Ala Ser Pro Ile Lys
305                 310                 315                 320 
Met Asp Leu Ala Pro Ser Lys Asp Met Gly Pro Pro Lys Glu Asn Lys
                325                 330                 335     
Lys Glu Thr Glu Arg Ala Ser Pro Ile Lys Met Asp Leu Ala Pro Ser
            340                 345                 350         
Lys Asp Met Gly Pro Pro Lys Glu Asn Lys Ile Val Pro Ala Lys Asp
        355                 360                 365             
Leu Val Leu Leu Ser Glu Ile Glu Val Ala Gln Ala Asn Asp Ile Ile
    370                 375                 380                 
Ser Ser Thr Glu Ile Ser Ser Ala Glu Lys Val Ala Leu Ser Ser Glu
385                 390                 395                 400 
Thr Glu Val Ala Leu Ala Arg Asp Met Thr Leu Pro Pro Glu Thr Asn
                405                 410                 415     
Val Ile Leu Thr Lys Asp Lys Ala Leu Pro Leu Glu Ala Glu Val Ala
            420                 425                 430         
Pro Val Lys Asp Met Ala Gln Leu Pro Glu Thr Glu Ile Ala Pro Ala
        435                 440                 445             
Lys Asp Val Ala Pro Ser Thr Val Lys Glu Val Gly Leu Leu Lys Asp
    450                 455                 460                 
Met Ser Pro Leu Ser Glu Thr Glu Met Ala Leu Gly Lys Asp Val Thr
465                 470                 475                 480 
Pro Pro Pro Glu Thr Glu Val Val Leu Ile Lys Asn Val Cys Leu Pro
                485                 490                 495     
Pro Glu Met Glu Val Ala Leu Thr Glu Asp Gln Val Pro Ala Leu Lys
            500                 505                 510         
Thr Glu Ala Pro Leu Ala Lys Asp Gly Val Leu Thr Leu Ala Asn Asn
        515                 520                 525             
Val Thr Pro Ala Lys Asp Val Pro Pro Leu Ser Glu Thr Glu Ala Thr
    530                 535                 540                 
Pro Val Pro Ile Lys Asp Met Glu Ile Ala Gln Thr Gln Lys Gly Ile
545                 550                 555                 560 
Ser Glu Asp Ser His Leu Glu Ser Leu Gln Asp Val Gly Gln Ser Ala
                565                 570                 575     
Ala Pro Thr Phe Met Ile Ser Pro Glu Thr Ile Thr Gly Thr Gly Lys
            580                 585                 590         
Lys Cys Ser Leu Pro Ala Glu Glu Asp Ser Val Leu Glu Lys Leu Gly
        595                 600                 605             
Glu Arg Lys Pro Cys Asn Ser Gln Pro Ser Glu Leu Ser Ser Glu Thr
    610                 615                 620                 
Ser Gly Ile Ala Arg Pro Glu Glu Gly Arg Pro Val Val Ser Gly Thr
625                 630                 635                 640 
Gly Asn Asp Ile Thr Thr Pro Pro Asn Lys Glu Leu Pro Pro Ser Pro
                645                 650                 655     
Glu Lys Lys Thr Lys Pro Leu Ala Thr Thr Gln Pro Ala Lys Thr Ser
            660                 665                 670         
Thr Ser Lys Ala Lys Thr Gln Pro Thr Ser Leu Pro Lys Gln Pro Ala
        675                 680                 685             
Pro Thr Thr Ile Gly Gly Leu Asn Lys Lys Pro Met Ser Leu Ala Ser
    690                 695                 700                 
Gly Leu Val Pro Ala Ala Pro Pro Lys Arg Pro Ala Val Ala Ser Ala
705                 710                 715                 720 
Arg Pro Ser Ile Leu Pro Ser Lys Asp Val Lys Pro Lys Pro Ile Ala
                725                 730                 735     
Asp Ala Lys Ala Pro Glu Lys Arg Ala Ser Pro Ser Lys Pro Ala Ser
            740                 745                 750         
Ala Pro Ala Ser Arg Ser Gly Ser Lys Ser Thr Gln Thr Val Ala Lys
        755                 760                 765             
Thr Thr Thr Ala Ala Ala Val Ala Ser Thr Gly Pro Ser Ser Arg Ser
    770                 775                 780                 
Pro Ser Thr Leu Leu Pro Lys Lys Pro Thr Ala Ile Lys Thr Glu Gly
785                 790                 795                 800 
Lys Pro Ala Glu Val Lys Lys Met Thr Ala Lys Ser Val Pro Ala Asp
                805                 810                 815     
Leu Ser Arg Pro Lys Ser Thr Ser Thr Ser Ser Met Lys Lys Thr Thr
            820                 825                 830         
Thr Leu Ser Gly Thr Ala Pro Ala Ala Gly Val Val Pro Ser Arg Val
        835                 840                 845             
Lys Ala Thr Pro Met Pro Ser Arg Pro Ser Thr Thr Pro Phe Ile Asp
    850                 855                 860                 
Lys Lys Pro Thr Ser Ala Lys Pro Ser Ser Thr Thr Pro Arg Leu Ser
865                 870                 875                 880 
Arg Leu Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys Asn Val Arg Ser
                885                 890                 895     
Lys Val Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Arg
            900                 905                 910         
Val Gln Ile Gln Asn Lys Lys Val Asp Ile Ser Lys Val Ser Ser Lys
        915                 920                 925             
Cys Gly Ser Lys Ala Asn Ile Lys His Lys Pro Gly Gly Gly Asp Val
    930                 935                 940                 
Lys Ile Glu Ser Gln Lys Leu Asn Phe Lys Glu Lys Ala Gln Ala Lys
945                 950                 955                 960 
Val Gly Ser Leu Asp Asn Val Gly His Leu Pro Ala Gly Gly Ala Val
                965                 970                 975     
Lys Thr Glu Gly Gly Gly Ser Glu Ala Pro Leu Cys Pro Gly Pro Pro
            980                 985                 990         
Ala Gly Glu Glu Pro Ala Ile Ser Glu Ala Ala Pro Glu Ala Gly Ala
        995                 1000                1005            
Pro Thr Ser Ala Ser Gly Leu Asn Gly His Pro Thr Leu Ser Gly Gly
    1010                1015                1020                
Gly Asp Gln Arg Glu Ala Gln Thr Leu Asp Ser Gln Ile Gln Glu Thr
1025                1030                1035                1040
Asn
    


<210> 6702
<211> 859
<212> PRT
<213> Homo sapiens

<400> 6702
Pro Ser Glu Leu Ile Asn Lys Ser Ser Pro Leu Glu Val Leu Glu Ser
 1               5                  10                  15      
Ala Ala Cys Glu Lys Leu Pro Thr Pro Thr Pro Gln Val Val Lys Glu
            20                  25                  30          
Gly Asp Ser Phe Pro Asp Thr Leu Ala Lys Asn Gly Gln Glu Ile Ala
        35                  40                  45              
Pro Ala Gln Ile Ser Lys Ser Leu Met Val Asp Asn Tyr Thr Lys Asp
    50                  55                  60                  
Gly Val Pro Gly Gln Glu Arg Pro Lys Gly Pro Ser Ala Val Val Pro
65                  70                  75                  80  
Ser Thr Ser Thr Gly Gly Val Ala Leu Pro Ile Thr Thr Ala Ile Glu
                85                  90                  95      
Thr Val Asn Ile His Gly Asp His Ser Leu Lys Asn Lys Ala Glu Leu
            100                 105                 110         
Ala Asp Ser Met Lys Asn Glu Ala Gly Ile Asp Glu Gly His Val Ile
        115                 120                 125             
Gly Glu Ser Glu Ser Val His Ser Gly Ala Ser Lys His Ser Val Glu
    130                 135                 140                 
Lys Val Thr Glu Leu Ala Lys Gly His Leu Leu Pro Gly Val Pro Val
145                 150                 155                 160 
Glu Asp Gln Ser Leu Pro Gly Glu Ala Arg Ala Leu Glu Gly Tyr Ala
                165                 170                 175     
Asp Arg Gly Asn Phe Pro Ala His Pro Val Asn Glu Glu Lys Glu Thr
            180                 185                 190         
Lys Glu Gly Ser Val Ala Val Gln Ile Pro Asp Leu Leu Glu Asp Lys
        195                 200                 205             
Ala Gln Lys Leu Ser Phe Cys Glu Asp Gln Asn Ala Gln Asp Arg Asn
    210                 215                 220                 
Ser Lys Gly Ser Asp Ser Leu Asn Lys Lys Val Asp Leu Thr Leu Leu
225                 230                 235                 240 
Ser Pro Lys Ser Glu Asn Asp Lys Leu Lys Glu Ile Ser Leu Ala Cys
                245                 250                 255     
Lys Ile Thr Glu Leu Glu Ser Val Ser Leu Pro Thr Pro Glu Ile Gln
            260                 265                 270         
Ser Asp Phe Leu His Ser Lys Val Glu Ala Pro Pro Ser Glu Val Ala
        275                 280                 285             
Asp Thr Leu Val Ile Met Thr Ala Ser Lys Gly Val Arg Leu Pro Glu
    290                 295                 300                 
Pro Lys Asp Lys Ile Leu Glu Thr Pro Gln Lys Met Thr Glu Lys Ser
305                 310                 315                 320 
Glu Ser Lys Thr Pro Gly Glu Gly Lys Lys Glu Asp Lys Ser Arg Met
                325                 330                 335     
Ala Glu Pro Met Lys Gly Tyr Met Arg Pro Thr Lys Ser Arg Gly Leu
            340                 345                 350         
Thr Pro Leu Leu Pro Lys Ser Thr Ile Gln Glu Gln Glu Arg His Lys
        355                 360                 365             
Gln Leu Lys Ser Ala Gly Ile Ala Arg Pro Glu Glu Gly Arg Pro Val
    370                 375                 380                 
Val Ser Gly Thr Gly Asn Asp Ile Thr Thr Pro Pro Asn Lys Glu Leu
385                 390                 395                 400 
Pro Pro Ser Pro Glu Lys Lys Thr Lys Pro Leu Ala Thr Thr Gln Pro
                405                 410                 415     
Ala Lys Thr Ser Thr Ser Lys Ala Lys Thr Gln Pro Thr Ser Leu Pro
            420                 425                 430         
Lys Gln Pro Ala Pro Thr Thr Ile Gly Gly Leu Asn Lys Lys Pro Met
        435                 440                 445             
Ser Leu Ala Ser Gly Leu Val Pro Ala Ala Pro Pro Lys Arg Pro Ala
    450                 455                 460                 
Val Ala Ser Ala Arg Pro Ser Ile Leu Pro Ser Lys Asp Val Lys Pro
465                 470                 475                 480 
Lys Pro Ile Ala Asp Ala Lys Ala Pro Glu Lys Arg Ala Ser Pro Ser
                485                 490                 495     
Lys Pro Ala Ser Ala Pro Ala Ser Arg Ser Gly Ser Lys Ser Thr Gln
            500                 505                 510         
Thr Val Ala Lys Thr Thr Thr Ala Ala Ala Val Ala Ser Thr Gly Pro
        515                 520                 525             
Ser Ser Arg Ser Pro Ser Thr Leu Leu Pro Lys Lys Pro Thr Ala Ile
    530                 535                 540                 
Lys Thr Glu Gly Lys Pro Ala Glu Val Lys Lys Met Thr Ala Lys Ser
545                 550                 555                 560 
Val Pro Ala Asp Leu Ser Arg Pro Lys Ser Thr Ser Thr Ser Ser Met
                565                 570                 575     
Lys Lys Thr Thr Thr Leu Ser Gly Thr Ala Pro Ala Ala Gly Val Val
            580                 585                 590         
Pro Ser Arg Val Lys Ala Thr Pro Met Pro Ser Arg Pro Ser Thr Thr
        595                 600                 605             
Pro Phe Ile Asp Lys Lys Pro Thr Ser Ala Lys Pro Ser Ser Thr Thr
    610                 615                 620                 
Pro Arg Leu Ser Arg Leu Ala Thr Asn Thr Ser Ala Pro Asp Leu Lys
625                 630                 635                 640 
Asn Val Arg Ser Lys Val Gly Ser Thr Glu Asn Ile Lys His Gln Pro
                645                 650                 655     
Gly Gly Gly Arg Ala Lys Val Glu Lys Lys Thr Glu Ala Ala Ala Thr
            660                 665                 670         
Thr Arg Lys Pro Glu Ser Asn Ala Val Thr Lys Thr Ala Gly Pro Ile
        675                 680                 685             
Ala Ser Ala Gln Lys Gln Pro Ala Gly Lys Val Gln Ile Val Ser Lys
    690                 695                 700                 
Lys Val Ser Tyr Ser His Ile Gln Ser Lys Cys Gly Ser Lys Asp Asn
705                 710                 715                 720 
Ile Lys His Val Pro Gly Gly Gly Asn Val Gln Ile Gln Asn Lys Lys
                725                 730                 735     
Val Asp Ile Ser Lys Val Ser Ser Lys Cys Gly Ser Lys Ala Asn Ile
            740                 745                 750         
Lys His Lys Pro Gly Gly Gly Asp Val Lys Ile Glu Ser Gln Lys Leu
        755                 760                 765             
Asn Phe Lys Glu Lys Ala Gln Ala Lys Val Gly Ser Leu Asp Asn Val
    770                 775                 780                 
Gly His Leu Pro Ala Gly Gly Ala Val Lys Thr Glu Gly Gly Gly Ser
785                 790                 795                 800 
Glu Ala Pro Leu Cys Pro Gly Pro Pro Ala Gly Glu Glu Pro Ala Ile
                805                 810                 815     
Ser Glu Ala Ala Pro Glu Ala Gly Ala Pro Thr Ser Ala Ser Gly Leu
            820                 825                 830         
Asn Gly His Pro Thr Leu Ser Gly Gly Gly Asp Gln Arg Glu Ala Gln
        835                 840                 845             
Thr Leu Asp Ser Gln Ile Gln Glu Thr Ser Ile
    850                 855                 


<210> 6703
<211> 520
<212> PRT
<213> Homo sapiens

<400> 6703
Met Ala Leu Ser Ser Arg Ala Arg Ala Phe Ser Val Glu Ala Leu Val
 1               5                  10                  15      
Gly Arg Pro Ser Lys Arg Lys Leu Gln Asp Pro Ile Gln Ala Glu Gln
            20                  25                  30          
Pro Glu Leu Arg Glu Lys Lys Gly Gly Glu Glu Glu Glu Glu Arg Arg
        35                  40                  45              
Ser Ser Ala Ala Gly Lys Ser Glu Pro Leu Glu Lys Gln Pro Lys Thr
    50                  55                  60                  
Glu Pro Ser Thr Ser Ala Ser Ser Gly Cys Gly Ser Asp Ser Gly Tyr
65                  70                  75                  80  
Gly Asn Ser Ser Glu Ser Leu Glu Glu Lys Asp Ile Gln Met Glu Leu
                85                  90                  95      
Gln Gly Ser Glu Leu Trp Lys Arg Phe His Asp Ile Gly Thr Glu Met
            100                 105                 110         
Ile Ile Thr Lys Ala Gly Arg Arg Met Phe Pro Ser Val Arg Val Lys
        115                 120                 125             
Val Lys Gly Leu Asp Pro Gly Lys Gln Tyr His Val Ala Ile Asp Val
    130                 135                 140                 
Val Pro Val Asp Ser Lys Arg Tyr Arg Tyr Val Tyr His Ser Ser Gln
145                 150                 155                 160 
Trp Met Val Ala Gly Asn Thr Asp His Leu Cys Ile Ile Pro Arg Phe
                165                 170                 175     
Tyr Val His Pro Asp Ser Pro Cys Ser Gly Glu Thr Trp Met Arg Gln
            180                 185                 190         
Ile Ile Ser Phe Asp Arg Met Lys Leu Thr Asn Asn Glu Met Asp Asp
        195                 200                 205             
Lys Gly His Ile Ile Leu Gln Ser Met His Lys Tyr Lys Pro Arg Val
    210                 215                 220                 
His Val Ile Glu Gln Gly Ser Ser Val Asp Leu Ser Gln Ile Gln Ser
225                 230                 235                 240 
Leu Pro Thr Glu Gly Val Lys Thr Phe Ser Phe Lys Glu Thr Glu Phe
                245                 250                 255     
Thr Thr Val Thr Ala Tyr Gln Asn Gln Gln Ile Thr Lys Leu Lys Ile
            260                 265                 270         
Glu Arg Asn Pro Phe Ala Lys Gly Phe Arg Asp Thr Gly Arg Asn Arg
        275                 280                 285             
Gly Val Leu Asp Gly Leu Leu Glu Thr Tyr Pro Trp Arg Pro Ser Phe
    290                 295                 300                 
Thr Leu Asp Phe Lys Thr Phe Gly Ala Asp Thr Gln Ser Gly Ser Ser
305                 310                 315                 320 
Gly Ser Ser Pro Val Thr Ser Ser Gly Gly Ala Pro Ser Pro Leu Asn
                325                 330                 335     
Ser Leu Leu Ser Pro Leu Cys Phe Ser Pro Met Phe His Leu Pro Thr
            340                 345                 350         
Ser Ser Leu Gly Met Pro Cys Pro Glu Ala Tyr Leu Pro Asn Val Asn
        355                 360                 365             
Leu Pro Leu Cys Tyr Lys Ile Cys Pro Thr Asn Phe Trp Gln Gln Gln
    370                 375                 380                 
Pro Leu Val Leu Pro Ala Pro Glu Arg Leu Ala Ser Ser Asn Ser Ser
385                 390                 395                 400 
Gln Ser Leu Ala Pro Leu Met Met Glu Val Pro Met Leu Ser Ser Leu
                405                 410                 415     
Gly Val Thr Asn Ser Lys Ser Gly Ser Ser Glu Asp Ser Ser Asp Gln
            420                 425                 430         
Tyr Leu Gln Ala Pro Asn Ser Thr Asn Gln Met Leu Tyr Gly Leu Gln
        435                 440                 445             
Ser Pro Gly Asn Ile Phe Leu Pro Asn Ser Ile Thr Pro Glu Ala Leu
    450                 455                 460                 
Ser Cys Ser Phe His Pro Ser Tyr Asp Phe Tyr Arg Tyr Asn Phe Ser
465                 470                 475                 480 
Met Pro Ser Arg Leu Ile Ser Gly Ser Asn His Leu Lys Val Asn Asp
                485                 490                 495     
Asp Ser Gln Val Ser Phe Gly Glu Gly Lys Cys Asn His Val His Trp
            500                 505                 510         
Tyr Pro Ala Ile Asn His Tyr Leu
        515                 520 


<210> 6704
<211> 202
<212> PRT
<213> Homo sapiens

<400> 6704
Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu Gly
 1               5                  10                  15      
Arg Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys Val
            20                  25                  30          
Val Val Val Arg Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr Arg
        35                  40                  45              
Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Thr Asn
    50                  55                  60                  
Pro Ser Arg Gly Pro Tyr His Phe Arg Ala Pro Ser Arg Ile Phe Trp
65                  70                  75                  80  
Arg Thr Val Arg Gly Met Leu Pro His Lys Thr Lys Arg Gly Gln Ala
                85                  90                  95      
Ala Leu Asp Arg Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr Asp
            100                 105                 110         
Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg Leu
        115                 120                 125             
Lys Pro Thr Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu Val
    130                 135                 140                 
Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg Lys
145                 150                 155                 160 
Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Leu Met Arg Leu
                165                 170                 175     
Arg Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr Thr
            180                 185                 190         
Glu Val Leu Lys Thr His Gly Leu Leu Val
        195                 200         


<210> 6705
<211> 821
<212> PRT
<213> Homo sapiens

<400> 6705
Met Glu Val Arg Gly Ser Phe Leu Ala Ala Cys Arg Arg Arg Met Ala
 1               5                  10                  15      
Thr Trp Arg Lys Asn Arg Asp Lys Asp Gly Phe Ser Asn Pro Gly Tyr
            20                  25                  30          
Arg Val Arg Gln Lys Asp Leu Gly Met Ile His Lys Ala Ala Ile Ala
        35                  40                  45              
Gly Asp Val Asn Lys Val Met Glu Ser Ile Leu Leu Arg Leu Asn Asp
    50                  55                  60                  
Leu Asn Asp Arg Asp Lys Lys Asn Arg Thr Ala Leu Leu Leu Ala Cys
65                  70                  75                  80  
Ala His Gly Arg Pro Gly Val Val Ala Asp Leu Val Ala Arg Lys Cys
                85                  90                  95      
Gln Leu Asn Leu Thr Asp Ser Glu Asn Arg Thr Ala Leu Ile Lys Ala
            100                 105                 110         
Val Gln Cys Gln Glu Glu Val Cys Ala Ser Ile Leu Leu Glu His Gly
        115                 120                 125             
Ala Asn Pro Asn Val Arg Asp Met Tyr Gly Asn Thr Ala Leu His Tyr
    130                 135                 140                 
Ala Ile Asp Asn Glu Asn Ile Ser Met Ala Arg Lys Leu Leu Ala Tyr
145                 150                 155                 160 
Gly Ala Asp Ile Glu Ala Arg Ser Gln Asp Gly His Thr Ser Leu Leu
                165                 170                 175     
Leu Ala Val Asn Arg Lys Lys Glu Gln Met Val Ala Phe Leu Leu Lys
            180                 185                 190         
Lys Lys Pro Asp Leu Thr Ala Ile Asp Asn Phe Gly Arg Thr Ala Leu
        195                 200                 205             
Ile Leu Ala Ala Arg Asn Gly Ser Thr Ser Val Val Tyr Gln Leu Leu
    210                 215                 220                 
Gln His Asn Ile Asp Val Phe Cys Gln Asp Ile Ser Gly Trp Thr Ala
225                 230                 235                 240 
Glu Asp Tyr Ala Val Ala Ser Lys Phe Gln Ala Leu Ala Arg Lys Thr
                245                 250                 255     
Ser Asn Glu Lys Ser Lys Val Lys Ser Gln Ile Tyr Phe Thr Asp Asp
            260                 265                 270         
Leu Asn Asp Ile Ser Gly Ser Ser Glu Lys Thr Ser Glu Asp Asp Glu
        275                 280                 285             
Leu Pro Tyr Ser Asp Asp Glu Asn Phe Met Leu Leu Ile Glu Gln Ser
    290                 295                 300                 
Gly Met Glu Cys Lys Asp Phe Val Ser Leu Ser Lys Ser Lys Asn Ala
305                 310                 315                 320 
Thr Ala Ala Cys Gly Arg Ser Ile Glu Asp Gln Lys Cys Tyr Cys Glu
                325                 330                 335     
Arg Leu Lys Val Lys Phe Gln Lys Met Lys Asn Asn Ile Ser Val Leu
            340                 345                 350         
Gln Lys Ala Phe Lys Ile Ser Ile Phe Asn Tyr Arg Phe Ile Leu Gln
        355                 360                 365             
Gln Gln Glu Glu Glu Arg Ile Lys Ala Glu Glu Leu Tyr Glu Lys Asp
    370                 375                 380                 
Ile Glu Glu Leu Lys Ile Met Glu Glu Gln Tyr Arg Thr Gln Thr Glu
385                 390                 395                 400 
Val Lys Lys Gln Ser Lys Leu Thr Leu Lys Ser Leu Glu Val Glu Leu
                405                 410                 415     
Lys Thr Val Arg Ser Asn Ser Asn Gln Asn Phe His Thr His Glu Arg
            420                 425                 430         
Glu Arg Asp Leu Trp Gln Glu Asn His Leu Met Arg Asp Glu Ile Ala
        435                 440                 445             
Arg Leu Arg Leu Glu Ile Asp Thr Ile Lys His Gln Asn Gln Glu Thr
    450                 455                 460                 
Glu Asn Lys Tyr Phe Lys Asp Ile Glu Ile Ile Lys Glu Asn Asn Glu
465                 470                 475                 480 
Asp Leu Glu Lys Thr Leu Lys Arg Asn Glu Glu Ala Leu Thr Lys Thr
                485                 490                 495     
Ile Thr Arg Tyr Ser Lys Glu Leu Asn Val Leu Met Asp Glu Asn Thr
            500                 505                 510         
Met Leu Asn Ser Glu Leu Gln Lys Glu Lys Gln Ser Met Ser Arg Leu
        515                 520                 525             
Glu Thr Glu Met Glu Ser Tyr Arg Cys Arg Leu Ala Ala Ala Leu Cys
    530                 535                 540                 
Asp His Asp Gln Arg Gln Ser Ser Lys Arg Asp Leu Gln Leu Ala Phe
545                 550                 555                 560 
Gln Ser Thr Val Asn Glu Trp Cys His Leu Gln Glu Asp Thr Asn Ser
                565                 570                 575     
His Ile Gln Ile Leu Ser Gln Gln Leu Ser Lys Ala Glu Ser Thr Ser
            580                 585                 590         
Ser Gly Leu Glu Thr Glu Leu His Tyr Glu Arg Glu Ala Leu Lys Glu
        595                 600                 605             
Lys Thr Leu His Ile Glu His Met Gln Gly Val Leu Ser Arg Thr Gln
    610                 615                 620                 
Arg Arg Leu Glu Asp Ile Glu His Met Tyr Gln Asn Asp Gln Pro Ile
625                 630                 635                 640 
Leu Glu Lys Tyr Val Arg Lys Gln Gln Ser Val Glu Asp Gly Leu Phe
                645                 650                 655     
Gln Leu Gln Ser Gln Asn Leu Leu Tyr Gln Gln Gln Cys Asn Asp Ala
            660                 665                 670         
Arg Lys Lys Ala Asp Asn Gln Glu Lys Thr Ile Ile Asn Ile Gln Val
        675                 680                 685             
Lys Cys Glu Asp Thr Val Glu Lys Leu Gln Ala Glu Cys Arg Lys Leu
    690                 695                 700                 
Glu Glu Asn Asn Lys Gly Leu Met Lys Glu Cys Thr Leu Leu Lys Glu
705                 710                 715                 720 
Arg Gln Cys Gln Tyr Glu Lys Glu Lys Glu Glu Arg Glu Val Val Arg
                725                 730                 735     
Arg Gln Leu Gln Arg Glu Val Asp Asp Ala Leu Asn Lys Gln Leu Leu
            740                 745                 750         
Leu Glu Ala Met Leu Glu Ile Ser Ser Glu Arg Arg Ile Asn Leu Glu
        755                 760                 765             
Asp Glu Ala Gln Ser Leu Lys Lys Lys Leu Gly Gln Met Arg Ser Gln
    770                 775                 780                 
Leu Gln Glu Met Gln Asn Gln Arg Thr Glu Ile Leu Arg Arg Ala Glu
785                 790                 795                 800 
Glu Leu Pro Asp His Met Gln Lys Tyr Ser Leu Lys Gln His Thr Lys
                805                 810                 815     
Tyr Leu Glu Tyr Leu
            820     


<210> 6706
<211> 966
<212> PRT
<213> Homo sapiens

<400> 6706
Glu Asp Gly Cys Leu Glu Ile Arg Gln Phe Ser Ser Cys Ser Pro Arg
 1               5                  10                  15      
Phe Asn Lys Val Tyr Ser Ser Met Glu Arg Leu Ser Leu Leu Glu Glu
            20                  25                  30          
Arg Arg Thr Pro Pro Pro Thr Lys Arg Ser Leu Ser Glu Glu Lys Glu
        35                  40                  45              
Asp His Ser Asp Gly Leu Ala Gly Leu Lys Gly Arg Asp Arg Ser Trp
    50                  55                  60                  
Val Ile Gly Ser Pro Glu Ile Leu Arg Lys Arg Leu Ser Val Ser Glu
65                  70                  75                  80  
Ser Ser His Thr Glu Ser Asp Ser Ser Pro Pro Met Thr Val Arg Arg
                85                  90                  95      
Arg Cys Ser Gly Leu Leu Asp Ala Pro Arg Phe Pro Glu Gly Pro Glu
            100                 105                 110         
Glu Ala Ser Ser Thr Leu Arg Arg Gln Pro Gln Glu Gly Ile Trp Val
        115                 120                 125             
Leu Thr Pro Pro Ser Gly Glu Gly Val Ser Gly Pro Val Thr Glu His
    130                 135                 140                 
Ser Gly Glu Gln Arg Pro Lys Leu Asp Glu Glu Ala Val Gly Arg Ser
145                 150                 155                 160 
Ser Gly Ser Ser Pro Ala Met Glu Thr Arg Gly Arg Gly Thr Ser Gln
                165                 170                 175     
Leu Ala Glu Gly Ala Thr Ala Lys Ala Ile Ser Asp Leu Ala Val Arg
            180                 185                 190         
Arg Ala Arg His Arg Leu Leu Ser Gly Asp Ser Thr Glu Lys Arg Thr
        195                 200                 205             
Ala Arg Pro Val Asn Lys Val Ile Lys Ser Ala Ser Ala Thr Ala Leu
    210                 215                 220                 
Ser Leu Leu Ile Pro Ser Glu His His Thr Cys Ser Pro Leu Ala Ser
225                 230                 235                 240 
Pro Met Ser Pro His Ser Gln Ser Ser Asn Pro Ser Ser Arg Asp Ser
                245                 250                 255     
Ser Pro Ser Arg Asp Phe Leu Pro Ala Leu Gly Ser Met Arg Pro Pro
            260                 265                 270         
Ile Ile Ile His Arg Ala Gly Lys Lys Tyr Gly Phe Thr Leu Arg Ala
        275                 280                 285             
Ile Arg Val Tyr Met Gly Asp Ser Asp Val Tyr Thr Val His His Met
    290                 295                 300                 
Val Trp His Val Glu Asp Gly Gly Pro Ala Ser Glu Ala Gly Leu Arg
305                 310                 315                 320 
Gln Gly Asp Leu Ile Thr His Val Asn Gly Glu Pro Val His Gly Leu
                325                 330                 335     
Val His Thr Glu Val Val Glu Leu Ile Leu Lys Ser Gly Asn Lys Val
            340                 345                 350         
Ala Ile Ser Thr Thr Pro Leu Glu Asn Thr Ser Ile Lys Val Gly Pro
        355                 360                 365             
Ala Arg Lys Gly Ser Tyr Lys Ala Lys Met Ala Arg Arg Ser Lys Arg
    370                 375                 380                 
Ser Arg Gly Lys Asp Gly Gln Glu Ser Arg Lys Arg Ser Ser Leu Phe
385                 390                 395                 400 
Arg Lys Ile Thr Lys Gln Ala Ser Leu Leu His Thr Ser Arg Ser Leu
                405                 410                 415     
Ser Ser Leu Asn Arg Ser Leu Ser Ser Gly Glu Ser Gly Pro Gly Ser
            420                 425                 430         
Pro Thr His Ser His Ser Leu Ser Pro Arg Ser Pro Thr Gln Gly Tyr
        435                 440                 445             
Arg Val Thr Pro Asp Ala Val His Ser Val Gly Gly Asn Ser Ser Gln
    450                 455                 460                 
Ser Ser Ser Pro Ser Ser Ser Val Pro Ser Ser Pro Ala Gly Ser Gly
465                 470                 475                 480 
His Thr Arg Pro Ser Ser Leu His Gly Leu Ala Pro Lys Leu Gln Arg
                485                 490                 495     
Gln Tyr Arg Ser Pro Arg Arg Lys Ser Ala Gly Ser Ile Pro Leu Ser
            500                 505                 510         
Pro Leu Ala His Thr Pro Ser Pro Pro Pro Pro Thr Ala Ser Pro Gln
        515                 520                 525             
Arg Ser Pro Ser Pro Leu Ser Gly His Val Ala Gln Ala Phe Pro Thr
    530                 535                 540                 
Lys Leu His Leu Ser Pro Pro Leu Gly Arg Gln Leu Ser Arg Pro Lys
545                 550                 555                 560 
Ser Ala Glu Pro Pro Arg Ser Pro Leu Leu Lys Arg Val Gln Ser Ala
                565                 570                 575     
Glu Lys Leu Ala Ala Ala Leu Ala Ala Ser Glu Lys Lys Leu Ala Thr
            580                 585                 590         
Ser Arg Lys His Ser Leu Asp Leu Pro His Ser Glu Leu Lys Lys Glu
        595                 600                 605             
Leu Pro Pro Arg Glu Val Ser Pro Leu Glu Val Val Gly Ala Arg Ser
    610                 615                 620                 
Val Leu Ser Gly Lys Gly Ala Leu Pro Gly Lys Gly Val Leu Gln Pro
625                 630                 635                 640 
Ala Pro Ser Arg Ala Leu Gly Thr Leu Arg Gln Asp Arg Ala Glu Arg
                645                 650                 655     
Arg Glu Ser Leu Gln Lys Gln Glu Ala Ile Arg Glu Val Asp Ser Ser
            660                 665                 670         
Glu Asp Asp Thr Glu Glu Gly Pro Glu Asn Ser Gln Gly Ala Gln Glu
        675                 680                 685             
Leu Ser Leu Ala Pro His Pro Glu Val Ser Gln Ser Val Ala Pro Lys
    690                 695                 700                 
Gly Ala Gly Glu Ser Gly Glu Glu Asp Pro Phe Pro Ser Arg Asp Pro
705                 710                 715                 720 
Arg Ser Leu Gly Pro Met Val Pro Ser Leu Leu Thr Gly Ile Thr Leu
                725                 730                 735     
Gly Pro Pro Arg Met Glu Ser Pro Ser Gly Pro His Arg Arg Leu Gly
            740                 745                 750         
Ser Pro Gln Ala Ile Glu Glu Ala Ala Ser Ser Ser Ser Ala Gly Pro
        755                 760                 765             
Asn Leu Gly Gln Ser Gly Ala Thr Asp Pro Ile Pro Pro Glu Gly Cys
    770                 775                 780                 
Trp Lys Ala Gln His Leu His Thr Gln Ala Leu Thr Ala Leu Ser Pro
785                 790                 795                 800 
Ser Thr Ser Gly Leu Thr Pro Thr Ser Ser Cys Ser Pro Pro Ser Ser
                805                 810                 815     
Thr Ser Gly Lys Leu Ser Met Trp Ser Trp Lys Ser Leu Ile Glu Gly
            820                 825                 830         
Pro Asp Arg Ala Ser Pro Ser Arg Lys Ala Thr Met Ala Gly Gly Leu
        835                 840                 845             
Ala Asn Leu Gln Asp Leu Glu Asn Thr Thr Pro Ala Gln Pro Lys Asn
    850                 855                 860                 
Leu Ser Pro Arg Glu Gln Gly Lys Thr Gln Pro Pro Ser Ala Pro Arg
865                 870                 875                 880 
Leu Ala His Pro Ser Tyr Glu Asp Pro Ser Gln Gly Trp Leu Trp Glu
                885                 890                 895     
Ser Glu Cys Ala Gln Ala Val Lys Glu Asp Pro Ala Leu Ser Ile Thr
            900                 905                 910         
Gln Val Pro Asp Ala Ser Gly Asp Arg Arg Gln Asp Val Pro Cys Arg
        915                 920                 925             
Gly Cys Pro Leu Thr Gln Lys Ser Glu Pro Ser Leu Arg Arg Gly Gln
    930                 935                 940                 
Glu Pro Gly Gly His Gln Lys His Arg Asp Leu Ala Leu Val Pro Asp
945                 950                 955                 960 
Glu Leu Leu Lys Gln Thr
                965     


<210> 6707
<211> 1530
<212> PRT
<213> Homo sapiens

<400> 6707
Met Pro Ile Arg Pro Asp Leu Gln Gln Leu Glu Lys Cys Ile Asp Asp
 1               5                  10                  15      
Ala Leu Arg Lys Asn Asp Phe Lys Pro Leu Lys Thr Leu Leu Gln Ile
            20                  25                  30          
Asp Ile Cys Glu Asp Val Lys Ile Lys Cys Ser Lys Gln Phe Phe His
        35                  40                  45              
Lys Val Asp Asn Leu Ile Cys Arg Glu Leu Asn Lys Glu Asp Ile His
    50                  55                  60                  
Asn Val Ser Ala Ile Leu Val Ser Val Gly Arg Cys Gly Lys Asn Ile
65                  70                  75                  80  
Ser Val Leu Gly Gln Ala Gly Leu Leu Thr Met Ile Lys Gln Gly Leu
                85                  90                  95      
Ile Gln Lys Met Val Ala Trp Phe Glu Lys Ser Lys Asp Ile Ile Gln
            100                 105                 110         
Ser Gln Gly Asn Ser Lys Asp Glu Ala Val Leu Asn Met Ile Glu Asp
        115                 120                 125             
Leu Val Asp Leu Leu Leu Val Ile His Asp Val Ser Asp Glu Gly Lys
    130                 135                 140                 
Lys Gln Val Val Glu Ser Phe Val Pro Arg Ile Cys Ser Leu Val Ile
145                 150                 155                 160 
Asp Ser Arg Val Asn Ile Cys Ile Gln Gln Glu Ile Ile Lys Lys Met
                165                 170                 175     
Asn Ala Met Leu Asp Lys Met Pro Gln Asp Ala Arg Lys Ile Leu Ser
            180                 185                 190         
Asn Gln Glu Met Leu Ile Leu Met Ser Ser Met Gly Glu Arg Ile Leu
        195                 200                 205             
Asp Ala Gly Asp Tyr Asp Leu Gln Val Gly Ile Val Glu Ala Leu Cys
    210                 215                 220                 
Arg Met Thr Thr Glu Lys Gln Arg Gln Glu Leu Ala His Gln Trp Phe
225                 230                 235                 240 
Ser Met Asp Phe Ile Ala Lys Ala Phe Lys Arg Ile Lys Asp Ser Glu
                245                 250                 255     
Phe Glu Thr Asp Cys Arg Ile Phe Leu Asn Leu Val Asn Gly Met Leu
            260                 265                 270         
Gly Asp Lys Arg Arg Val Phe Thr Phe Pro Cys Leu Ser Ala Phe Leu
        275                 280                 285             
Asp Lys Tyr Glu Leu Gln Ile Pro Ser Asp Glu Lys Leu Glu Glu Phe
    290                 295                 300                 
Trp Ile Asp Phe Asn Leu Gly Ser Gln Thr Leu Ser Phe Tyr Ile Ala
305                 310                 315                 320 
Gly Asp Asn Asp Asp His Gln Trp Glu Ala Val Thr Val Pro Glu Glu
                325                 330                 335     
Lys Val Gln Ile Tyr Ser Ile Glu Val Arg Glu Ser Lys Lys Leu Leu
            340                 345                 350         
Thr Ile Ile Leu Lys Asn Thr Val Lys Ile Ser Lys Arg Glu Gly Lys
        355                 360                 365             
Glu Leu Leu Leu Tyr Phe Asp Ala Ser Leu Glu Ile Thr Asn Val Thr
    370                 375                 380                 
Gln Lys Ile Phe Gly Ala Thr Lys His Arg Glu Ser Ile Arg Lys Gln
385                 390                 395                 400 
Gly Ile Ser Val Ala Lys Thr Ser Leu His Ile Leu Phe Asp Ala Ser
                405                 410                 415     
Gly Ser Gln Ile Leu Val Pro Glu Ser Gln Ile Ser Pro Val Gly Glu
            420                 425                 430         
Glu Leu Val Ser Leu Lys Glu Lys Ser Lys Ser Pro Lys Glu Phe Ala
        435                 440                 445             
Lys Pro Ser Lys Tyr Ile Lys Asn Ser Asp Lys Gly Asn Arg Asn Asn
    450                 455                 460                 
Ser Gln Leu Glu Lys Thr Thr Pro Ser Lys Arg Lys Met Ser Glu Ala
465                 470                 475                 480 
Ser Met Ile Val Ser Gly Ala Asp Arg Tyr Thr Met Arg Ser Pro Val
                485                 490                 495     
Leu Phe Ser Asn Thr Ser Ile Pro Pro Arg Arg Arg Arg Ile Lys Pro
            500                 505                 510         
Pro Leu Gln Met Thr Ser Ser Ala Glu Lys Pro Ser Val Ser Gln Thr
        515                 520                 525             
Ser Glu Asn Arg Val Asp Asn Ala Ala Ser Leu Lys Ser Arg Ser Ser
    530                 535                 540                 
Glu Gly Arg His Arg Arg Asp Asn Ile Asp Lys His Ile Lys Thr Ala
545                 550                 555                 560 
Lys Cys Val Glu Asn Thr Glu Asn Lys Asn Val Glu Phe Pro Asn Gln
                565                 570                 575     
Asn Phe Ser Glu Leu Gln Asp Val Ile Pro Asp Ser Gln Ala Ala Glu
            580                 585                 590         
Lys Arg Asp His Thr Ile Leu Pro Gly Val Leu Asp Asn Ile Cys Gly
        595                 600                 605             
Asn Lys Ile His Ser Lys Trp Ala Cys Trp Thr Pro Val Thr Asn Ile
    610                 615                 620                 
Glu Leu Cys Asn Asn Gln Arg Ala Ser Thr Ser Ser Gly Asp Thr Leu
625                 630                 635                 640 
Asn Gln Asp Ile Val Ile Asn Lys Lys Leu Thr Lys Gln Lys Ser Ser
                645                 650                 655     
Ser Ser Ile Ser Asp His Asn Ser Glu Gly Thr Gly Lys Val Lys Tyr
            660                 665                 670         
Lys Lys Glu Gln Thr Asp His Ile Lys Ile Asp Lys Ala Glu Val Glu
        675                 680                 685             
Val Cys Lys Lys His Asn Gln Gln Gln Asn His Pro Lys Tyr Ser Gly
    690                 695                 700                 
Gln Lys Asn Thr Glu Asn Ala Lys Gln Ser Asp Trp Pro Val Glu Ser
705                 710                 715                 720 
Glu Thr Thr Phe Lys Ser Val Leu Leu Asn Lys Thr Ile Glu Glu Ser
                725                 730                 735     
Leu Ile Tyr Arg Lys Lys Tyr Ile Leu Ser Lys Asp Val Asn Thr Ala
            740                 745                 750         
Thr Cys Asp Lys Asn Pro Ser Ala Ser Lys Asn Val Gln Ser His Arg
        755                 760                 765             
Lys Ala Glu Lys Glu Leu Thr Ser Glu Leu Asn Ser Trp Asp Ser Lys
    770                 775                 780                 
Gln Lys Lys Met Arg Glu Lys Ser Lys Gly Lys Glu Phe Thr Asn Val
785                 790                 795                 800 
Ala Glu Ser Leu Ile Ser Gln Ile Asn Lys Arg Tyr Lys Thr Lys Asp
                805                 810                 815     
Asp Ile Lys Ser Thr Arg Lys Leu Lys Glu Ser Leu Ile Asn Ser Gly
            820                 825                 830         
Phe Ser Asn Lys Pro Val Val Gln Leu Ser Lys Glu Lys Val Gln Lys
        835                 840                 845             
Lys Ser Tyr Arg Lys Leu Lys Thr Thr Phe Val Asn Val Thr Ser Glu
    850                 855                 860                 
Cys Pro Val Asn Asp Val Tyr Asn Phe Asn Leu Asn Gly Ala Asp Asp
865                 870                 875                 880 
Pro Ile Ile Lys Leu Gly Ile Gln Glu Phe Gln Ala Thr Ala Lys Glu
                885                 890                 895     
Ala Cys Ala Asp Arg Ser Ile Arg Leu Val Gly Pro Arg Asn His Asp
            900                 905                 910         
Glu Leu Lys Ser Ser Val Lys Thr Lys Asp Lys Lys Ile Ile Thr Asn
        915                 920                 925             
His Gln Lys Lys Asn Leu Phe Ser Asp Thr Glu Thr Glu Tyr Arg Cys
    930                 935                 940                 
Asp Asp Ser Lys Thr Asp Ile Ser Trp Leu Arg Glu Pro Lys Ser Lys
945                 950                 955                 960 
Pro Gln Leu Ile Asp Tyr Ser Arg Asn Lys Asn Val Lys Asn His Lys
                965                 970                 975     
Ser Gly Lys Ser Arg Ser Ser Leu Glu Lys Gly Gln Pro Ser Ser Lys
            980                 985                 990         
Met Thr Pro Ser Lys Asn Ile Thr Lys Lys Met Asp Lys Thr Ile Pro
        995                 1000                1005            
Glu Gly Arg Ile Arg Leu Pro Arg Lys Ala Thr Lys Thr Lys Lys Asn
    1010                1015                1020                
Tyr Lys Asp Leu Ser Asn Ser Glu Ser Glu Cys Glu Gln Glu Phe Ser
1025                1030                1035                1040
His Ser Phe Lys Glu Asn Ile Pro Val Lys Glu Glu Asn Ile His Ser
                1045                1050                1055    
Arg Met Lys Thr Val Lys Leu Pro Lys Lys Gln Gln Lys Val Phe Cys
            1060                1065                1070        
Ala Glu Thr Glu Lys Glu Leu Ser Lys Gln Trp Lys Asn Ser Ser Leu
        1075                1080                1085            
Leu Lys Asp Ala Ile Arg Asp Asn Cys Leu Asp Leu Ser Pro Arg Ser
    1090                1095                1100                
Leu Ser Gly Ser Pro Ser Ser Ile Glu Val Thr Arg Cys Ile Glu Lys
1105                1110                1115                1120
Ile Thr Glu Lys Asp Phe Thr Gln Asp Tyr Asp Cys Ile Thr Lys Ser
                1125                1130                1135    
Ile Ser Pro Tyr Pro Lys Thr Ser Ser Leu Glu Ser Leu Asn Ser Asn
            1140                1145                1150        
Ser Gly Val Gly Gly Thr Ile Lys Ser Pro Lys Asn Asn Glu Lys Asn
        1155                1160                1165            
Phe Leu Cys Ala Ser Glu Ser Cys Ser Pro Ile Pro Arg Pro Leu Phe
    1170                1175                1180                
Leu Pro Arg His Thr Pro Thr Lys Ser Asn Thr Ile Val Asn Arg Lys
1185                1190                1195                1200
Lys Ile Ser Ser Leu Val Leu Thr Gln Glu Thr Gln Asn Ser Asn Ser
                1205                1210                1215    
Tyr Ser Asp Val Ser Ser Tyr Ser Ser Glu Glu Arg Phe Met Glu Ile
            1220                1225                1230        
Glu Ser Pro His Ile Asn Glu Asn Tyr Ile Gln Ser Lys Arg Glu Glu
        1235                1240                1245            
Ser His Leu Ala Ser Ser Leu Ser Lys Ser Ser Glu Gly Arg Glu Lys
    1250                1255                1260                
Thr Trp Phe Asp Met Pro Cys Asp Ala Thr His Val Ser Gly Pro Thr
1265                1270                1275                1280
Gln His Leu Ser Arg Lys Arg Ile Tyr Ile Glu Asp Asn Leu Ser Asn
                1285                1290                1295    
Ser Asn Glu Val Glu Met Glu Glu Lys Gly Glu Arg Arg Ala Asn Leu
            1300                1305                1310        
Leu Pro Lys Lys Leu Cys Lys Ile Glu Asp Ala Asp His His Ile His
        1315                1320                1325            
Lys Met Ser Glu Ser Val Ser Ser Leu Ser Thr Asn Asp Phe Ser Ile
    1330                1335                1340                
Pro Trp Glu Thr Trp Gln Asn Glu Phe Ala Gly Ile Glu Met Thr Tyr
1345                1350                1355                1360
Glu Thr Tyr Glu Arg Leu Asn Ser Glu Phe Lys Arg Arg Asn Asn Ile
                1365                1370                1375    
Arg His Lys Met Leu Ser Tyr Phe Thr Thr Gln Ser Trp Lys Thr Ala
            1380                1385                1390        
Gln Gln His Leu Arg Thr Met Asn His Gln Ser Gln Asp Ser Arg Ile
        1395                1400                1405            
Lys Lys Leu Asp Lys Phe Gln Phe Ile Ile Ile Glu Glu Leu Glu Asn
    1410                1415                1420                
Phe Glu Lys Asp Ser Gln Ser Leu Lys Asp Leu Glu Lys Glu Phe Val
1425                1430                1435                1440
Asp Phe Trp Glu Lys Ile Phe Gln Lys Phe Ser Ala Tyr Gln Lys Ser
                1445                1450                1455    
Glu Gln Gln Arg Leu His Leu Leu Lys Thr Ser Leu Ala Lys Ser Val
            1460                1465                1470        
Phe Cys Asn Thr Asp Ser Glu Glu Thr Val Phe Thr Ser Glu Met Cys
        1475                1480                1485            
Leu Met Lys Glu Asp Met Lys Val Leu Gln Asp Arg Leu Leu Lys Asp
    1490                1495                1500                
Met Leu Glu Glu Glu Leu Leu Asn Val Arg Arg Glu Leu Met Ser Val
1505                1510                1515                1520
Phe Met Ser His Glu Arg Asn Ala Asn Val
                1525                1530


<210> 6708
<211> 574
<212> PRT
<213> Homo sapiens

<400> 6708
Met Gly Asn Asn Phe Ser Ser Ile Pro Ser Leu Pro Arg Gly Asn Pro
 1               5                  10                  15      
Ser Arg Ala Pro Arg Gly His Pro Gln Asn Leu Lys Asp Ser Ile Gly
            20                  25                  30          
Gly Pro Phe Pro Val Thr Ser His Arg Cys His His Lys Gln Lys His
        35                  40                  45              
Cys Pro Ala Val Leu Pro Ser Gly Gly Leu Pro Ala Thr Pro Leu Leu
    50                  55                  60                  
Phe His Pro His Thr Lys Gly Ser Gln Ile Leu Met Asp Leu Ser His
65                  70                  75                  80  
Lys Ala Val Lys Arg Gln Ala Ser Phe Cys Asn Ala Ile Thr Phe Ser
                85                  90                  95      
Asn Arg Pro Val Leu Ile Tyr Glu Gln Val Arg Leu Lys Ile Thr Lys
            100                 105                 110         
Lys Gln Cys Cys Trp Ser Gly Ala Leu Arg Leu Gly Phe Thr Ser Lys
        115                 120                 125             
Asp Pro Ser Arg Ile His Pro Asp Ser Leu Pro Lys Tyr Ala Cys Pro
    130                 135                 140                 
Asp Leu Val Ser Gln Ser Gly Phe Trp Ala Lys Ala Leu Pro Glu Glu
145                 150                 155                 160 
Phe Ala Asn Glu Gly Asn Ile Ile Ala Phe Trp Val Asp Lys Lys Gly
                165                 170                 175     
Arg Val Phe His Arg Ile Asn Asp Ser Ala Val Met Leu Phe Phe Ser
            180                 185                 190         
Gly Val Arg Thr Ala Asp Pro Leu Trp Ala Leu Val Asp Val Tyr Gly
        195                 200                 205             
Leu Thr Arg Gly Val Gln Leu Leu Asp Ser Glu Leu Val Leu Pro Asp
    210                 215                 220                 
Cys Leu Arg Pro Arg Ser Phe Thr Ala Leu Arg Arg Pro Ser Leu Arg
225                 230                 235                 240 
Arg Glu Ala Asp Asp Ala Arg Leu Ser Val Ser Leu Cys Asp Leu Asn
                245                 250                 255     
Val Pro Gly Ala Asp Gly Asp Glu Ala Ala Pro Ala Ala Gly Cys Pro
            260                 265                 270         
Ile Pro Gln Asn Ser Leu Asn Ser Gln His Ser Arg Ala Leu Pro Ala
        275                 280                 285             
Gln Leu Asp Gly Asp Leu Arg Phe His Ala Leu Arg Ala Gly Ala His
    290                 295                 300                 
Val Arg Ile Leu Asp Glu Gln Thr Val Ala Arg Val Glu His Gly Arg
305                 310                 315                 320 
Asp Glu Arg Ala Leu Val Phe Thr Ser Arg Pro Val Arg Val Ala Glu
                325                 330                 335     
Thr Ile Phe Val Lys Val Thr Arg Ser Gly Gly Ala Arg Pro Gly Ala
            340                 345                 350         
Leu Ser Phe Gly Val Thr Thr Cys Asp Pro Gly Thr Leu Arg Pro Ala
        355                 360                 365             
Asp Leu Pro Phe Ser Pro Glu Ala Leu Val Asp Arg Lys Glu Phe Trp
    370                 375                 380                 
Ala Val Cys Arg Val Pro Gly Pro Leu His Ser Gly Asp Ile Leu Gly
385                 390                 395                 400 
Leu Val Val Asn Ala Asp Gly Glu Leu His Leu Ser His Asn Gly Ala
                405                 410                 415     
Ala Ala Gly Met Gln Leu Cys Val Asp Ala Ser Gln Pro Leu Trp Met
            420                 425                 430         
Leu Phe Gly Leu His Gly Thr Ile Thr Gln Ile Arg Ile Leu Gly Ser
        435                 440                 445             
Thr Ile Leu Ala Glu Arg Gly Ile Pro Ser Leu Pro Cys Ser Pro Ala
    450                 455                 460                 
Ser Thr Pro Thr Ser Pro Ser Ala Leu Gly Ser Arg Leu Ser Asp Pro
465                 470                 475                 480 
Leu Leu Ser Thr Cys Ser Ser Gly Pro Leu Gly Ser Ser Ala Gly Gly
                485                 490                 495     
Thr Ala Pro Asn Ser Pro Val Ser Leu Pro Glu Ser Pro Val Thr Pro
            500                 505                 510         
Gly Leu Gly Gln Trp Ser Asp Glu Cys Thr Ile Cys Tyr Glu His Ala
        515                 520                 525             
Val Asp Thr Val Ile Tyr Thr Cys Gly His Met Cys Leu Cys Tyr Ala
    530                 535                 540                 
Cys Gly Leu Arg Leu Lys Lys Ala Leu His Ala Cys Cys Pro Ile Cys
545                 550                 555                 560 
Arg Arg Pro Ile Lys Asp Ile Ile Lys Thr Tyr Arg Ser Ser
                565                 570                 


<210> 6709
<211> 311
<212> PRT
<213> Homo sapiens

<400> 6709
Met Ala Asp Val Ile Asn Val Ser Val Asn Leu Glu Ala Phe Ser Gln
 1               5                  10                  15      
Ala Ile Ser Ala Ile Gln Ala Leu Arg Ser Ser Val Ser Arg Val Phe
            20                  25                  30          
Asp Cys Leu Lys Asp Gly Met Arg Asn Lys Glu Thr Leu Glu Gly Arg
        35                  40                  45              
Glu Lys Ala Phe Ile Ala His Phe Gln Asp Asn Leu His Ser Val Asn
    50                  55                  60                  
Arg Asp Leu Asn Glu Leu Glu Arg Leu Ser Asn Leu Val Gly Lys Pro
65                  70                  75                  80  
Ser Glu Asn His Pro Leu His Asn Ser Gly Leu Leu Ser Leu Asp Pro
                85                  90                  95      
Val Gln Asp Lys Thr Pro Leu Tyr Ser Gln Leu Leu Gln Ala Tyr Lys
            100                 105                 110         
Trp Ser Asn Lys Leu Gln Tyr His Ala Gly Leu Ala Ser Gly Leu Leu
        115                 120                 125             
Asn Gln Gln Ser Leu Lys Arg Ser Ala Asn Gln Met Gly Val Ser Ala
    130                 135                 140                 
Lys Arg Arg Pro Lys Ala Gln Pro Thr Thr Leu Val Leu Pro Pro Gln
145                 150                 155                 160 
Tyr Val Asp Asp Val Ile Ser Arg Ile Asp Arg Met Phe Pro Glu Met
                165                 170                 175     
Ser Ile His Leu Ser Arg Pro Asn Gly Thr Ser Ala Met Leu Leu Val
            180                 185                 190         
Thr Leu Gly Lys Val Leu Lys Val Ile Val Val Met Arg Ser Leu Phe
        195                 200                 205             
Ile Asp Arg Thr Ile Val Lys Gly Tyr Asn Glu Asn Val Tyr Thr Glu
    210                 215                 220                 
Asp Gly Lys Leu Asp Ile Trp Ser Lys Ser Asn Tyr Gln Val Phe Gln
225                 230                 235                 240 
Lys Val Thr Asp His Ala Thr Thr Ala Leu Leu His Tyr Gln Leu Pro
                245                 250                 255     
Gln Met Pro Asp Val Val Val Arg Ser Phe Met Thr Trp Leu Arg Ser
            260                 265                 270         
Tyr Ile Lys Leu Phe Gln Ala Pro Cys Gln Arg Cys Gly Lys Phe Leu
        275                 280                 285             
Gln Asp Gly Leu Pro Pro Thr Trp Arg Asp Phe Arg Thr Leu Glu Ala
    290                 295                 300                 
Phe His Asp Thr Cys Arg Gln
305                 310     


<210> 6710
<211> 1677
<212> PRT
<213> Homo sapiens

<400> 6710
Met Thr Phe Val Lys Gly His Leu Pro Arg Val Arg His Lys Gly Ser
 1               5                  10                  15      
Ala Gly Ala Glu Ile Arg Glu Gly Arg Cys Gly Glu Ala Pro Leu Asp
            20                  25                  30          
Cys Glu Gln Ala Gln Val Arg Gly Gln Gly Gln Thr Gly Pro Ala Ser
        35                  40                  45              
Thr Lys Met Ser Ala Thr Ser Trp Phe Leu Val Ser Ser Ser Gly Ala
    50                  55                  60                  
Arg His Arg Leu Pro Arg Glu Leu Ile Phe Val Gly Arg Glu Glu Cys
65                  70                  75                  80  
Glu Leu Met Leu Gln Cys Pro Cys Ala Gln Cys Lys Pro Gly Thr Glu
                85                  90                  95      
Leu Val Pro Ser Glu Gln Ala Leu Asn Asp Ala Gly Thr Trp Thr Gln
            100                 105                 110         
Ala Gly Leu Pro Ala Val Ala Val Thr Pro Val Val Ala Gln Ala Val
        115                 120                 125             
Val Gln Glu Thr Thr Ala Trp Ala Gly Pro Asp Leu Leu Cys Pro Val
    130                 135                 140                 
His Arg Ala Gly Leu Leu Arg Val Pro Val Ala Ala Asn Gly Glu Leu
145                 150                 155                 160 
Gly Val Asp Lys Gln His Ala Val Ile Asn Tyr Asp Gln Asp Arg Asp
                165                 170                 175     
Glu His Trp Val Lys Asp Leu Gly Ser Leu Asn Gly Thr Phe Val Asn
            180                 185                 190         
Asp Met Arg Ile Pro Asp Gln Lys Tyr Val Thr Leu Lys Leu Asn Asp
        195                 200                 205             
Val Ile Arg Phe Gly Tyr Asp Ser Asn Met Tyr Val Leu Glu Arg Val
    210                 215                 220                 
Gln His Arg Val Pro Glu Glu Ala Leu Lys His Glu Lys Tyr Thr Ser
225                 230                 235                 240 
Gln Leu Gln Val Ser Val Lys Gly Leu Ala Pro Lys Arg Ser Glu Ala
                245                 250                 255     
Leu Pro Glu His Thr Pro Tyr Cys Glu Ala Ser Asn Pro Arg Pro Glu
            260                 265                 270         
Lys Gly Asp Arg Arg Pro Gly Thr Glu Ala Ala Ser Tyr Arg Thr Pro
        275                 280                 285             
Leu Tyr Gly Gln Pro Ser Trp Trp Gly Glu Asp Asp Gly Ser Thr Leu
    290                 295                 300                 
Pro Asp Ala Gln Arg Gln Gly Glu Pro Tyr Pro Glu Arg Pro Lys Gly
305                 310                 315                 320 
Pro Val Gln Gln Asp Gly Glu Leu His Gly Phe Arg Ala Pro Ala Glu
                325                 330                 335     
Pro Gln Gly Cys Ser Phe Arg Arg Glu Pro Ser Tyr Phe Glu Ile Pro
            340                 345                 350         
Thr Lys Glu Thr Pro Gln Pro Ser Gln Pro Pro Glu Val Pro Ala His
        355                 360                 365             
Glu Met Pro Thr Lys Asp Ala Glu Ala Gly Gly Gly Gly Ala Ala Pro
    370                 375                 380                 
Val Val Gln Ser His Ala Ser Phe Thr Ile Glu Phe Asp Asp Cys Ser
385                 390                 395                 400 
Pro Gly Lys Met Lys Ile Lys Asp His Ile Thr Lys Phe Ser Leu Arg
                405                 410                 415     
Gln Arg Arg Pro Pro Gly Lys Glu Ala Thr Pro Gly Glu Met Val Ser
            420                 425                 430         
Ala Glu Thr Lys Val Ala Asp Trp Leu Val Gln Asn Asp Pro Ser Leu
        435                 440                 445             
Leu His Arg Val Gly Pro Gly Asp Asp Arg His Ser Thr Lys Ser Asp
    450                 455                 460                 
Leu Pro Val His Thr Arg Thr Leu Lys Gly His Lys His Glu Asp Gly
465                 470                 475                 480 
Thr Gln Ser Asp Ser Glu Asp Pro Leu Ala Lys Ala Ala Ser Ala Ala
                485                 490                 495     
Gly Val Pro Leu Glu Ala Ser Gly Glu Gln Val Arg Leu Gln Arg Gln
            500                 505                 510         
Ile Lys Arg Asp Pro Gln Glu Leu Leu His Asn Gln Gln Ala Phe Val
        515                 520                 525             
Ile Glu Phe Phe Asp Glu Asp Thr Pro Arg Lys Lys Arg Ser Gln Ser
    530                 535                 540                 
Phe Thr His Ser Pro Ser Gly Asp Pro Lys Ala Asp Lys Arg Arg Gly
545                 550                 555                 560 
Pro Thr Pro Ala Asp Arg Asp Arg Pro Ser Val Pro Ala Pro Val Gln
                565                 570                 575     
Ala Gly Gly Arg Ser Ser Gly Pro Gln Arg Ala Gly Ser Leu Lys Arg
            580                 585                 590         
Glu Lys Thr Glu Glu Arg Leu Gly Ser Pro Ser Pro Ala Ser Arg Thr
        595                 600                 605             
Pro Ala Arg Pro Phe Gly Ser Val Gly Arg Arg Ser Arg Leu Ala Gln
    610                 615                 620                 
Asp Phe Met Ala Gln Cys Leu Arg Glu Ser Ser Pro Ala Ala Arg Pro
625                 630                 635                 640 
Ser Pro Glu Lys Val Pro Pro Val Leu Pro Ala Pro Leu Thr Pro His
                645                 650                 655     
Gly Thr Ser Pro Val Gly Pro Pro Thr Pro Pro Pro Ala Pro Thr Asp
            660                 665                 670         
Pro Gln Leu Thr Lys Ala Arg Lys Gln Glu Glu Asp Asp Ser Leu Ser
        675                 680                 685             
Asp Ala Gly Thr Tyr Thr Ile Glu Thr Glu Ala Gln Asp Thr Glu Val
    690                 695                 700                 
Glu Glu Ala Arg Lys Met Ile Asp Gln Val Phe Gly Val Leu Glu Ser
705                 710                 715                 720 
Pro Glu Leu Ser Arg Ala Ser Ser Ala Thr Phe Arg Pro Val Ile Arg
                725                 730                 735     
Gly Asp Arg Asp Glu Ser Asp Asp Gly Gly Val Ala Gln Arg Met Ala
            740                 745                 750         
Leu Leu Gln Glu Phe Ala Ser Arg Pro Leu Gly Ala Ala Pro Gln Ala
        755                 760                 765             
Glu His Gln Gly Leu Pro Val Pro Gly Ser Pro Gly Gly Gln Lys Trp
    770                 775                 780                 
Val Ser Arg Trp Ala Ser Leu Ala Asp Ser Tyr Ser Asp Pro Gly Leu
785                 790                 795                 800 
Thr Glu Asp Gly Leu Gly Arg Arg Gly Gly Glu Pro Glu Gly Ser Leu
                805                 810                 815     
Pro Val Arg Met Arg Arg Arg Leu Pro Gln Leu Pro Ser Glu Arg Ala
            820                 825                 830         
Asp Ser Pro Ala Gly Pro Glu Ser Ser Arg Arg Ser Gly Pro Gly Pro
        835                 840                 845             
Pro Glu Leu Asp Ser Glu Gln Pro Ser Arg Leu Phe Gly Gln Glu Glu
    850                 855                 860                 
Leu Asp Pro Asp Ser Leu Ser Asp Ala Ser Gly Ser Asp Gly Gly Arg
865                 870                 875                 880 
Gly Pro Glu Pro Gly Val Glu Pro Gln Asp Ser Arg Arg Arg Ser Pro
                885                 890                 895     
Gln Glu Gly Pro Thr Trp Ser Arg Gly Arg Arg Ser Pro Arg Ala Pro
            900                 905                 910         
Gly Glu Pro Thr Pro Ala Ser Phe Phe Ile Gly Asp Gln Asn Gly Asp
        915                 920                 925             
Ala Val Leu Ser Arg Lys Pro Leu Ala Ala Pro Gly Asp Gly Glu Gly
    930                 935                 940                 
Leu Gly Gln Thr Ala Gln Pro Ser Pro Pro Ala Arg Asp Gly Val Tyr
945                 950                 955                 960 
Val Ser Ala Asn Gly Arg Met Val Ile Gln Leu Arg Pro Gly Arg Ser
                965                 970                 975     
Pro Glu Pro Asp Gly Pro Ala Pro Ala Phe Leu Arg Gln Glu Ser Phe
            980                 985                 990         
Thr Lys Glu Pro Ala Ser Gly Pro Pro Ala Pro Gly Lys Pro Pro His
        995                 1000                1005            
Ile Ser Ser His Pro Leu Leu Gln Asp Leu Ala Ala Thr Arg Ala Ala
    1010                1015                1020                
Arg Met Asp Phe His Ser Gln Asp Thr His Leu Ile Leu Lys Glu Thr
1025                1030                1035                1040
Glu Thr Ala Leu Ala Ala Leu Glu Ala Arg Leu Leu Ser Asn Ser Val
                1045                1050                1055    
Asp Ala Glu Cys Glu Gly Gly Ser Thr Pro Arg Pro Pro Glu Asp Ala
            1060                1065                1070        
Leu Ser Gly Asp Ser Asp Val Asp Thr Ala Ser Thr Val Ser Leu Arg
        1075                1080                1085            
Ser Gly Lys Ser Gly Pro Ser Pro Thr Thr Pro Gln Pro Leu Arg Ala
    1090                1095                1100                
Gln Lys Glu Met Ser Pro Ser Pro Pro Ala Ala Gln Asp Pro Gly Gly
1105                1110                1115                1120
Thr Ala Leu Val Ser Ala Arg Glu Gln Ser Ser Glu Arg Gln His His
                1125                1130                1135    
Pro Leu Gly Pro Thr Asp Met Gly Arg Gly Glu Pro Val Arg Arg Ser
            1140                1145                1150        
Ala Ile Arg Arg Gly His Arg Pro Arg Gly Ser Leu Asp Trp Pro Ser
        1155                1160                1165            
Glu Glu Arg Gly Pro Val Leu Ala His Leu Pro Ser Ser Asp Val Met
    1170                1175                1180                
Ala Ser Asn His Glu Thr Pro Glu Ala Thr Gly Ala Gly Arg Leu Gly
1185                1190                1195                1200
Ser Arg Arg Lys Pro Ala Ala Pro Pro Pro Ser Pro Ala Ala Arg Glu
                1205                1210                1215    
Glu Gln Ser Arg Ser Ser Ala Ser Ser Gln Lys Gly Pro Gln Ala Leu
            1220                1225                1230        
Thr Arg Ser Asn Ser Leu Ser Thr Pro Arg Pro Thr Arg Ala Ser Arg
        1235                1240                1245            
Leu Arg Arg Ala Arg Leu Gly Asp Ala Ser Asp Thr Glu Ala Ala Asp
    1250                1255                1260                
Gly Glu Arg Gly Ser Leu Gly Asn Pro Glu Pro Val Gly Arg Pro Ala
1265                1270                1275                1280
Ala Glu Gln Ala Lys Lys Leu Ser Arg Leu Asp Ile Leu Ala Met Pro
                1285                1290                1295    
Arg Lys Arg Ala Gly Ser Phe Thr Gly Thr Ser Asp Pro Glu Ala Ala
            1300                1305                1310        
Pro Ala Arg Thr Ser Phe Ser Gly Arg Ser Val Glu Leu Cys Cys Ala
        1315                1320                1325            
Ser Arg Lys Pro Thr Met Ala Glu Ala Arg Ala Val Ser Arg Lys Ala
    1330                1335                1340                
Ala Asn Thr Ala Thr Thr Thr Gly Pro Arg Gln Pro Phe Ser Arg Ala
1345                1350                1355                1360
Arg Ser Gly Ser Ala Arg Tyr Thr Ser Thr Thr Gln Thr Pro Arg Ala
                1365                1370                1375    
Gly Ser Ser Ser Arg Ala Arg Ser Arg Ala Pro Gly Pro Arg Asp Thr
            1380                1385                1390        
Asp Asp Asp Glu Glu Glu Pro Asp Pro Tyr Gly Phe Ile Val Gln Thr
        1395                1400                1405            
Ala Glu Ile Ala Glu Ile Ala Arg Leu Ser Gln Thr Leu Val Lys Asp
    1410                1415                1420                
Val Ala Ile Leu Ala Gln Glu Ile His Asp Val Ala Gly Asp Gly Asp
1425                1430                1435                1440
Thr Leu Gly Ser Ser Glu Pro Ala His Ser Ala Ser Leu Ser Asn Met
                1445                1450                1455    
Pro Ser Thr Pro Ala Ser Thr Ile Ser Ala Arg Glu Glu Leu Val Gln
            1460                1465                1470        
Arg Ile Pro Glu Ala Ser Leu Asn Phe Gln Lys Val Pro Pro Gly Ser
        1475                1480                1485            
Leu Asn Ser Arg Asp Phe Asp Gln Asn Met Asn Asp Ser Cys Glu Asp
    1490                1495                1500                
Ala Leu Ala Asn Lys Thr Arg Pro Arg Asn Arg Glu Glu Val Ile Phe
1505                1510                1515                1520
Asp Asn Leu Met Leu Asn Pro Val Ser Gln Leu Ser Gln Ala Ile Arg
                1525                1530                1535    
Glu Asn Thr Glu His Leu Ala Glu Lys Met Lys Ile Leu Phe Gln Asn
            1540                1545                1550        
Thr Gly Arg Ala Trp Glu Asp Leu Glu Ala Arg Ile Asn Ala Glu Asn
        1555                1560                1565            
Glu Val Pro Ile Leu Lys Thr Ser Asn Lys Glu Ile Ser Ser Ile Leu
    1570                1575                1580                
Lys Glu Leu Arg Arg Val Gln Lys Gln Leu Glu Val Ile Asn Ala Ile
1585                1590                1595                1600
Val Asp Pro Ser Gly Ser Leu Asp Leu Leu Thr Gly Asn Arg Ser Leu
                1605                1610                1615    
Ala Ser Ser Ala Gln Pro Gly Leu Gly Lys Gly Arg Val Ala Ala Gln
            1620                1625                1630        
Ser Pro Pro Ser Pro Ala Ser Ala Glu Ala Leu Leu Pro Ala Leu Pro
        1635                1640                1645            
Leu Arg Asn Phe Pro Gln Arg Ala Ser Cys Gly Pro Pro Ser Leu Pro
    1650                1655                1660                
Asp Pro Thr Phe Leu Pro Asp Ala Glu Arg Phe Leu Ile
1665                1670                1675        


<210> 6711
<211> 586
<212> PRT
<213> Homo sapiens

<400> 6711
Met Ala Ala Ser Gly Val Glu Lys Ser Ser Lys Lys Lys Thr Glu Lys
 1               5                  10                  15      
Lys Leu Ala Ala Arg Glu Glu Ala Lys Leu Leu Ala Gly Phe Met Gly
            20                  25                  30          
Val Met Asn Asn Met Arg Lys Gln Lys Thr Leu Cys Asp Val Ile Leu
        35                  40                  45              
Met Val Gln Glu Arg Lys Ile Pro Ala His Arg Val Val Leu Ala Ala
    50                  55                  60                  
Ala Ser His Phe Phe Asn Leu Met Phe Thr Thr Asn Met Leu Glu Ser
65                  70                  75                  80  
Lys Ser Phe Glu Val Glu Leu Lys Asp Ala Glu Pro Asp Ile Ile Glu
                85                  90                  95      
Gln Leu Val Glu Phe Ala Tyr Thr Ala Arg Ile Ser Val Asn Ser Asn
            100                 105                 110         
Asn Val Gln Ser Leu Leu Asp Ala Ala Asn Gln Tyr Gln Ile Glu Pro
        115                 120                 125             
Val Lys Lys Met Cys Val Asp Phe Leu Lys Glu Gln Val Asp Ala Ser
    130                 135                 140                 
Asn Cys Leu Gly Ile Ser Val Leu Ala Glu Cys Leu Asp Cys Pro Glu
145                 150                 155                 160 
Leu Lys Ala Thr Ala Asp Asp Phe Ile His Gln His Phe Thr Glu Val
                165                 170                 175     
Tyr Lys Thr Asp Glu Phe Leu Gln Leu Asp Val Lys Arg Val Thr His
            180                 185                 190         
Leu Leu Asn Gln Asp Thr Leu Thr Val Arg Ala Glu Asp Gln Val Tyr
        195                 200                 205             
Asp Ala Ala Val Arg Trp Leu Lys Tyr Asp Glu Pro Asn Arg Gln Pro
    210                 215                 220                 
Phe Met Val Asp Ile Leu Ala Lys Val Arg Phe Pro Leu Ile Ser Lys
225                 230                 235                 240 
Asn Phe Leu Ser Lys Thr Val Gln Ala Glu Pro Leu Ile Gln Asp Asn
                245                 250                 255     
Pro Glu Cys Leu Lys Met Val Ile Ser Gly Met Arg Tyr His Leu Leu
            260                 265                 270         
Ser Pro Glu Asp Arg Glu Glu Leu Val Asp Gly Thr Arg Pro Arg Arg
        275                 280                 285             
Lys Lys His Asp Tyr Arg Ile Ala Leu Phe Gly Gly Ser Gln Pro Gln
    290                 295                 300                 
Ser Cys Arg Tyr Phe Asn Pro Lys Asp Tyr Ser Trp Thr Asp Ile Arg
305                 310                 315                 320 
Cys Pro Phe Glu Lys Arg Arg Asp Ala Ala Cys Val Phe Trp Asp Asn
                325                 330                 335     
Val Val Tyr Ile Leu Gly Gly Ser Gln Leu Phe Pro Ile Lys Arg Met
            340                 345                 350         
Asp Cys Tyr Asn Val Val Lys Asp Ser Trp Tyr Ser Lys Leu Gly Pro
        355                 360                 365             
Pro Thr Pro Arg Asp Ser Leu Ala Ala Cys Ala Ala Glu Gly Lys Ile
    370                 375                 380                 
Tyr Thr Ser Gly Gly Ser Glu Val Gly Asn Ser Ala Leu Tyr Leu Phe
385                 390                 395                 400 
Glu Cys Tyr Asp Thr Arg Thr Glu Ser Trp His Thr Lys Pro Ser Met
                405                 410                 415     
Leu Thr Gln Arg Cys Ser His Gly Met Val Glu Ala Asn Gly Leu Ile
            420                 425                 430         
Tyr Val Cys Gly Gly Ser Leu Gly Asn Asn Val Ser Gly Arg Val Leu
        435                 440                 445             
Asn Ser Cys Glu Val Tyr Asp Pro Ala Thr Glu Thr Trp Thr Glu Leu
    450                 455                 460                 
Cys Pro Met Ile Glu Ala Arg Lys Asn His Gly Leu Val Phe Val Lys
465                 470                 475                 480 
Asp Lys Ile Phe Ala Val Gly Gly Gln Asn Gly Leu Gly Gly Leu Asp
                485                 490                 495     
Asn Val Glu Tyr Tyr Asp Ile Lys Leu Asn Glu Trp Lys Met Val Ser
            500                 505                 510         
Pro Met Pro Trp Lys Gly Val Thr Val Lys Cys Ala Ala Val Gly Ser
        515                 520                 525             
Ile Val Tyr Val Leu Ala Gly Phe Gln Gly Val Gly Arg Leu Gly His
    530                 535                 540                 
Ile Leu Glu Tyr Asn Thr Glu Thr Asp Lys Trp Val Ala Asn Ser Lys
545                 550                 555                 560 
Val Arg Ala Phe Pro Val Thr Ser Cys Leu Ile Cys Val Val Asp Thr
                565                 570                 575     
Cys Gly Ala Asn Glu Glu Thr Leu Glu Thr
            580                 585     


<210> 6712
<211> 586
<212> PRT
<213> Homo sapiens

<400> 6712
Met Ala Ala Ser Gly Val Glu Lys Ser Ser Lys Lys Lys Thr Glu Lys
 1               5                  10                  15      
Lys Leu Ala Ala Arg Glu Glu Ala Lys Leu Leu Ala Gly Phe Met Gly
            20                  25                  30          
Val Met Asn Asn Met Arg Lys Gln Lys Thr Leu Cys Asp Val Ile Leu
        35                  40                  45              
Met Val Gln Glu Arg Lys Ile Pro Ala His Arg Val Val Leu Ala Ala
    50                  55                  60                  
Ala Ser His Phe Phe Asn Leu Met Phe Thr Thr Asn Met Leu Glu Ser
65                  70                  75                  80  
Lys Ser Phe Glu Leu Glu Leu Lys Asp Ala Glu Pro Asp Ile Ile Glu
                85                  90                  95      
Gln Leu Val Glu Phe Ala Tyr Thr Ala Arg Ile Ser Val Asn Ser Asn
            100                 105                 110         
Asn Val Gln Ser Leu Leu Asp Ala Ala Asn Gln Tyr Gln Ile Glu Pro
        115                 120                 125             
Val Lys Lys Met Cys Val Asp Phe Leu Lys Glu Gln Val Asp Ala Ser
    130                 135                 140                 
Asn Cys Leu Gly Ile Ser Val Leu Ala Glu Cys Leu Asp Cys Pro Glu
145                 150                 155                 160 
Leu Lys Ala Thr Ala Asp Asp Phe Ile His Gln His Phe Thr Glu Val
                165                 170                 175     
Tyr Lys Thr Asp Glu Phe Leu Gln Leu Asp Val Lys Arg Val Thr His
            180                 185                 190         
Leu Leu Asn Gln Asp Thr Leu Thr Val Arg Ala Glu Asp Gln Val Tyr
        195                 200                 205             
Asp Ala Ala Val Arg Trp Leu Lys Tyr Asp Glu Pro Asn Arg Gln Pro
    210                 215                 220                 
Phe Met Val Asp Ile Leu Ala Lys Val Arg Phe Pro Leu Ile Ser Lys
225                 230                 235                 240 
Asn Phe Leu Ser Lys Thr Val Gln Ala Glu Pro Leu Ile Gln Asp Asn
                245                 250                 255     
Pro Glu Cys Leu Lys Met Val Ile Ser Gly Met Arg Tyr His Leu Leu
            260                 265                 270         
Ser Pro Glu Asp Arg Glu Glu Leu Val Asp Gly Thr Arg Pro Arg Arg
        275                 280                 285             
Lys Lys His Asp Tyr Arg Ile Ala Leu Phe Gly Gly Ser Gln Pro Gln
    290                 295                 300                 
Ser Cys Arg Tyr Phe Asn Pro Lys Asp Tyr Ser Trp Thr Asp Ile Arg
305                 310                 315                 320 
Cys Pro Phe Glu Lys Arg Arg Asp Ala Ala Cys Val Phe Trp Asp Asn
                325                 330                 335     
Val Val Tyr Ile Leu Gly Gly Ser Gln Leu Phe Pro Ile Lys Arg Met
            340                 345                 350         
Asp Cys Tyr Asn Val Val Lys Asp Ser Trp Tyr Ser Lys Leu Gly Pro
        355                 360                 365             
Pro Thr Pro Arg Asp Ser Leu Ala Ala Cys Ala Ala Glu Gly Lys Ile
    370                 375                 380                 
Tyr Thr Ser Gly Gly Ser Glu Val Gly Asn Ser Ala Leu Tyr Leu Phe
385                 390                 395                 400 
Glu Cys Tyr Asp Thr Arg Thr Glu Ser Trp His Thr Lys Pro Ser Met
                405                 410                 415     
Leu Thr Gln Arg Cys Ser His Gly Met Val Glu Ala Asn Gly Leu Ile
            420                 425                 430         
Tyr Val Cys Gly Gly Ser Leu Gly Asn Asn Val Ser Gly Arg Val Leu
        435                 440                 445             
Asn Ser Cys Glu Val Tyr Asp Pro Ala Thr Glu Thr Trp Thr Glu Leu
    450                 455                 460                 
Cys Pro Met Ile Glu Ala Arg Lys Asn His Gly Leu Val Phe Val Lys
465                 470                 475                 480 
Asp Lys Ile Phe Ala Val Gly Gly Gln Asn Gly Leu Gly Gly Leu Asp
                485                 490                 495     
Asn Val Glu Tyr Tyr Asp Ile Lys Leu Asn Glu Trp Lys Met Val Ser
            500                 505                 510         
Pro Met Pro Trp Lys Gly Val Thr Val Lys Cys Ala Ala Val Gly Ser
        515                 520                 525             
Ile Val Tyr Val Leu Ala Gly Phe Gln Gly Val Gly Arg Leu Gly His
    530                 535                 540                 
Ile Leu Glu Tyr Asn Thr Glu Thr Asp Lys Trp Val Ala Asn Ser Lys
545                 550                 555                 560 
Val Arg Ala Phe Pro Val Thr Ser Cys Leu Ile Cys Val Val Asp Thr
                565                 570                 575     
Cys Gly Ala Asn Glu Glu Thr Leu Glu Thr
            580                 585     


<210> 6713
<211> 564
<212> PRT
<213> Homo sapiens

<400> 6713
Met Leu Gly Gly Thr Asp Cys Arg Thr Phe Leu Thr Ser His Ile Asn
 1               5                  10                  15      
Leu Lys Lys Thr Leu Cys Asp Val Ile Leu Met Val Gln Glu Arg Lys
            20                  25                  30          
Ile Pro Ala His Arg Val Val Leu Ala Ala Ala Ser His Phe Phe Asn
        35                  40                  45              
Leu Met Phe Thr Thr Asn Met Leu Glu Ser Lys Ser Phe Glu Val Glu
    50                  55                  60                  
Leu Lys Asp Ala Glu Pro Asp Ile Ile Glu Gln Leu Val Glu Phe Ala
65                  70                  75                  80  
Tyr Thr Ala Arg Ile Ser Val Asn Ser Asn Asn Val Gln Ser Leu Leu
                85                  90                  95      
Asp Ala Ala Asn Gln Tyr Gln Ile Glu Pro Val Lys Lys Met Cys Val
            100                 105                 110         
Asp Phe Leu Arg Glu Gln Val Asp Ala Ser Asn Cys Leu Gly Ile Ser
        115                 120                 125             
Val Leu Ala Glu Cys Leu Asp Cys Pro Glu Leu Lys Ala Thr Ala Asp
    130                 135                 140                 
Asp Phe Ile His Gln His Phe Thr Glu Val Tyr Lys Thr Asp Glu Phe
145                 150                 155                 160 
Leu Gln Leu Asp Val Lys Arg Val Thr His Leu Leu Asn Gln Asp Thr
                165                 170                 175     
Leu Thr Val Arg Ala Glu Asp Gln Val Tyr Asp Ala Ala Val Arg Trp
            180                 185                 190         
Leu Lys Tyr Asp Glu Pro Asn Arg Gln Pro Phe Met Val Asp Ile Leu
        195                 200                 205             
Ala Lys Val Arg Phe Pro Leu Ile Ser Lys Asn Phe Leu Ser Lys Thr
    210                 215                 220                 
Val Gln Ala Glu Pro Leu Ile Gln Asp Asn Pro Glu Cys Leu Lys Met
225                 230                 235                 240 
Val Ile Ser Gly Met Arg Tyr His Leu Leu Ser Pro Glu Asp Arg Glu
                245                 250                 255     
Glu Leu Val Asp Gly Thr Arg Pro Arg Arg Lys Lys His Asp Tyr Arg
            260                 265                 270         
Ile Ala Leu Phe Gly Gly Ser Gln Pro Gln Ser Cys Arg Tyr Phe Asn
        275                 280                 285             
Pro Lys Asp Tyr Ser Trp Thr Asp Ile Arg Cys Pro Phe Glu Lys Arg
    290                 295                 300                 
Arg Asp Ala Ala Cys Val Phe Trp Asp Asn Val Val Tyr Ile Leu Gly
305                 310                 315                 320 
Gly Ser Gln Leu Phe Pro Ile Lys Arg Met Asp Cys Tyr Asn Val Val
                325                 330                 335     
Lys Asp Ser Trp Tyr Ser Lys Leu Gly Pro Pro Thr Pro Arg Asp Ser
            340                 345                 350         
Leu Ala Ala Cys Ala Ala Glu Gly Lys Ile Tyr Thr Ser Gly Gly Ser
        355                 360                 365             
Glu Val Gly Asn Ser Ala Leu Tyr Leu Phe Glu Cys Tyr Asp Thr Arg
    370                 375                 380                 
Thr Glu Ser Trp His Thr Lys Pro Ser Met Leu Thr Gln Arg Cys Ser
385                 390                 395                 400 
His Gly Met Val Glu Ala Asn Gly Leu Ile Tyr Val Cys Gly Gly Ser
                405                 410                 415     
Leu Gly Asn Asn Val Ser Gly Arg Val Leu Asn Ser Cys Glu Val Tyr
            420                 425                 430         
Asp Pro Ala Thr Glu Thr Trp Thr Glu Leu Cys Pro Met Ile Glu Ala
        435                 440                 445             
Arg Lys Asn His Gly Leu Val Phe Val Lys Asp Lys Ile Phe Ala Val
    450                 455                 460                 
Gly Gly Gln Asn Gly Leu Gly Gly Leu Asp Asn Val Glu Tyr Tyr Asp
465                 470                 475                 480 
Ile Lys Leu Asn Glu Trp Lys Met Val Ser Pro Met Pro Trp Lys Gly
                485                 490                 495     
Val Thr Val Lys Cys Ala Ala Val Gly Ser Ile Val Tyr Val Leu Ala
            500                 505                 510         
Gly Phe Gln Gly Val Gly Arg Leu Gly His Ile Leu Glu Tyr Asn Thr
        515                 520                 525             
Glu Thr Asp Lys Trp Val Ala Asn Ser Lys Val Arg Ala Phe Pro Val
    530                 535                 540                 
Thr Ser Cys Leu Ile Cys Val Val Asp Thr Cys Gly Ala Asn Glu Glu
545                 550                 555                 560 
Thr Leu Glu Thr
                


<210> 6714
<211> 257
<212> PRT
<213> Homo sapiens

<400> 6714
Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro
 1               5                  10                  15      
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly
            20                  25                  30          
Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp
        35                  40                  45              
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg
    50                  55                  60                  
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg
65                  70                  75                  80  
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp
                85                  90                  95      
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn
            100                 105                 110         
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val
        115                 120                 125             
Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys
    130                 135                 140                 
Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala
145                 150                 155                 160 
Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro
                165                 170                 175     
Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu
            180                 185                 190         
Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala
        195                 200                 205             
Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala
    210                 215                 220                 
Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met
225                 230                 235                 240 
Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln
                245                 250                 255     
Ser
    


<210> 6715
<211> 453
<212> PRT
<213> Homo sapiens

<400> 6715
Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro
 1               5                  10                  15      
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly
            20                  25                  30          
Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp
        35                  40                  45              
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg
    50                  55                  60                  
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg
65                  70                  75                  80  
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp
                85                  90                  95      
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn
            100                 105                 110         
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val
        115                 120                 125             
Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys
    130                 135                 140                 
Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala
145                 150                 155                 160 
Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro
                165                 170                 175     
Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu
            180                 185                 190         
Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala
        195                 200                 205             
Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala
    210                 215                 220                 
Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met
225                 230                 235                 240 
Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln
                245                 250                 255     
Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala
            260                 265                 270         
Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala
        275                 280                 285             
Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser
    290                 295                 300                 
Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met
305                 310                 315                 320 
His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly
                325                 330                 335     
Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr
            340                 345                 350         
Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro
        355                 360                 365             
Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala
    370                 375                 380                 
Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg
385                 390                 395                 400 
Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Phe Ala Leu Leu Asn
                405                 410                 415     
Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His
            420                 425                 430         
Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala
        435                 440                 445             
Val Trp Arg Pro Tyr
    450             


<210> 6716
<211> 242
<212> PRT
<213> Homo sapiens

<400> 6716
Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro
 1               5                  10                  15      
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly
            20                  25                  30          
Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp
        35                  40                  45              
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg
    50                  55                  60                  
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg
65                  70                  75                  80  
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp
                85                  90                  95      
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn
            100                 105                 110         
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val
        115                 120                 125             
Ala Arg Phe Asn Asp Leu Arg Phe Val Asp Gly Pro Arg Glu Pro Arg
    130                 135                 140                 
Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser
145                 150                 155                 160 
Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met
                165                 170                 175     
Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser
            180                 185                 190         
Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln
        195                 200                 205             
Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser
    210                 215                 220                 
Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr
225                 230                 235                 240 
Pro Ile
        


<210> 6717
<211> 480
<212> PRT
<213> Homo sapiens

<400> 6717
Met Ala Ser Asp Ser Ile Phe Glu Ser Phe Pro Ser Tyr Pro Gln Cys
 1               5                  10                  15      
Phe Met Arg Glu Cys Ile Leu Gly Met Asn Pro Ser Arg Asp Val His
            20                  25                  30          
Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro Ser Thr Ala Leu Ser
        35                  40                  45              
Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly Ala Pro Asp Ala Gly
    50                  55                  60                  
Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp Arg Ser Met Val Glu
65                  70                  75                  80  
Val Leu Ala Asp His Pro Gly Glu Leu Val Arg Thr Asp Ser Pro Asn
                85                  90                  95      
Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg Cys Asn Lys Thr Leu
            100                 105                 110         
Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp Val Pro Asp Gly Thr
        115                 120                 125             
Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu
    130                 135                 140                 
Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val Ala Arg Phe Asn Asp
145                 150                 155                 160 
Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr
                165                 170                 175     
Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala
            180                 185                 190         
Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln
        195                 200                 205             
Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser Phe Ser Glu Arg
    210                 215                 220                 
Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met Arg Val Ser Pro
225                 230                 235                 240 
His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser Leu Asn His Ser
                245                 250                 255     
Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln Asp Thr Arg Gln
            260                 265                 270         
Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Gln Tyr Leu
        275                 280                 285             
Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr Pro Ile Ser Pro
    290                 295                 300                 
Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala Glu Leu Ser Ser Arg
305                 310                 315                 320 
Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser Asp Pro Arg Gln Phe
                325                 330                 335     
Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met His Tyr Pro Gly Ala
            340                 345                 350         
Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly Ile Gly Ile Gly Met
        355                 360                 365             
Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr Tyr Leu Pro Pro Pro
    370                 375                 380                 
Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro Phe Gln Ala Ser Ser
385                 390                 395                 400 
Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala Gly Ser Tyr Gln Phe
                405                 410                 415     
Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile Leu Pro Pro Cys
            420                 425                 430         
Thr Asn Ala Ser Thr Gly Phe Ala Leu Leu Asn Pro Ser Leu Pro Asn
        435                 440                 445             
Gln Ser Asp Val Val Glu Ala Glu Gly Ser His Ser Asn Ser Pro Thr
    450                 455                 460                 
Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala Val Trp Arg Pro Tyr
465                 470                 475                 480 


<210> 6718
<211> 472
<212> PRT
<213> Homo sapiens

<400> 6718
Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro
 1               5                  10                  15      
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly
            20                  25                  30          
Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp
        35                  40                  45              
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg
    50                  55                  60                  
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg
65                  70                  75                  80  
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp
                85                  90                  95      
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn
            100                 105                 110         
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val
        115                 120                 125             
Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys
    130                 135                 140                 
Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala
145                 150                 155                 160 
Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro
                165                 170                 175     
Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu
            180                 185                 190         
Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala
        195                 200                 205             
Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala
    210                 215                 220                 
Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met
225                 230                 235                 240 
Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln
                245                 250                 255     
Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala
            260                 265                 270         
Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala
        275                 280                 285             
Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser
    290                 295                 300                 
Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met
305                 310                 315                 320 
His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly
                325                 330                 335     
Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr
            340                 345                 350         
Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro
        355                 360                 365             
Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala
    370                 375                 380                 
Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg
385                 390                 395                 400 
Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Phe Ala Leu Leu Asn
                405                 410                 415     
Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His
            420                 425                 430         
Ser Asn Ser Pro Thr Asn Met Gly Gly Ala Ser Cys Ser Arg Gln Ala
        435                 440                 445             
Arg Arg Asp Pro Gly Pro Trp Ala Arg Thr Pro Ser Trp Gly Arg Gly
    450                 455                 460                 
Arg Pro Thr Asp Arg Ile Ser Leu
465                 470         


<210> 6719
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6719
Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Thr
 1               5                  10                  15      
Ala Ala Met Lys Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val
            20                  25                  30          
Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe
        35                  40                  45              
Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala Ile Lys Ile Thr
    50                  55                  60                  
Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp
65                  70                  75                  80  
Gln Thr Lys Pro Gly Ser Leu Ser Phe Ser Glu Arg Leu Ser Glu Leu
                85                  90                  95      
Glu Gln Leu Arg Arg Thr Ala Met Arg Val Ser Pro His His Pro Ala
            100                 105                 110         
Pro Thr Pro Asn Pro Arg Ala Ser Leu Asn His Ser Thr Ala Phe Asn
        115                 120                 125             
Pro Gln Pro Gln Ser Gln Met Gln Asp Thr Arg Gln Ile Gln Pro Ser
    130                 135                 140                 
Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Gln Tyr Leu Gly Ser Ile Ala
145                 150                 155                 160 
Ser Pro Ser Val His Pro Ala Thr Pro Ile Ser Pro Gly Arg Ala Ser
                165                 170                 175     
Gly Met Thr Thr Leu Ser Ala Glu Leu Ser Ser Arg Leu Ser Thr Ala
            180                 185                 190         
Pro Asp Leu Thr Ala Phe Ser Asp Pro Arg Gln Phe Pro Ala Leu Pro
        195                 200                 205             
Ser Ile Ser Asp Pro Arg Met His Tyr Pro Gly Ala Phe Thr Tyr Ser
    210                 215                 220                 
Pro Thr Pro Val Thr Ser Gly Ile Gly Ile Gly Met Ser Ala Met Gly
225                 230                 235                 240 
Ser Ala Thr Arg Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser
                245                 250                 255     
Ser Gln Ala Gln Gly Gly Pro Phe Gln Ala Ser Ser Pro Ser Tyr His
            260                 265                 270         
Leu Tyr Tyr Gly Ala Ser Ala Gly Ser Tyr Gln Phe Ser Met Val Gly
        275                 280                 285             
Gly Glu Arg Ser Pro Pro Arg Ile Leu Pro Pro Cys Thr Asn Ala Ser
    290                 295                 300                 
Thr Gly Phe Ala Leu Leu Asn Pro Ser Leu Pro Asn Gln Ser Asp Val
305                 310                 315                 320 
Val Glu Ala Glu Gly Ser His Ser Asn Ser Pro Thr Asn Met Ala Pro
                325                 330                 335     
Ser Ala Arg Leu Glu Glu Ala Val Trp Arg Pro Tyr
            340                 345             


<210> 6720
<211> 468
<212> PRT
<213> Homo sapiens

<400> 6720
Met Pro Ala Ala Pro Arg Gly Pro Ala Gln Gly Glu Ala Ala Ala Arg
 1               5                  10                  15      
Thr Arg Ser Arg Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro Ser
            20                  25                  30          
Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly Ala
        35                  40                  45              
Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp Arg
    50                  55                  60                  
Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg Thr
65                  70                  75                  80  
Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg Cys
                85                  90                  95      
Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp Val
            100                 105                 110         
Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr
        115                 120                 125             
Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val Ala
    130                 135                 140                 
Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser
145                 150                 155                 160 
Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr
                165                 170                 175     
Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro Arg
            180                 185                 190         
Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser
        195                 200                 205             
Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met
    210                 215                 220                 
Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser
225                 230                 235                 240 
Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln
                245                 250                 255     
Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser
            260                 265                 270         
Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr
        275                 280                 285             
Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala Glu
    290                 295                 300                 
Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser Asp
305                 310                 315                 320 
Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met His
                325                 330                 335     
Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly Ile
            340                 345                 350         
Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr Tyr
        355                 360                 365             
Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro Phe
    370                 375                 380                 
Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala Gly
385                 390                 395                 400 
Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile
                405                 410                 415     
Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Phe Ala Leu Leu Asn Pro
            420                 425                 430         
Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His Ser
        435                 440                 445             
Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala Val
    450                 455                 460                 
Trp Arg Pro Tyr
465             


<210> 6721
<211> 456
<212> PRT
<213> Homo sapiens

<400> 6721
Met Asn Pro Ser Arg Asp Val His Asp Ala Ser Thr Ser Arg Arg Phe
 1               5                  10                  15      
Thr Pro Pro Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu
            20                  25                  30          
Pro Leu Gly Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg
        35                  40                  45              
Ser Gly Asp Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu
    50                  55                  60                  
Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr
65                  70                  75                  80  
His Trp Arg Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala
                85                  90                  95      
Leu Gly Asp Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn
            100                 105                 110         
Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys
        115                 120                 125             
Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly
    130                 135                 140                 
Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro
145                 150                 155                 160 
Gln Val Ala Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro
                165                 170                 175     
Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro
            180                 185                 190         
Gly Ser Leu Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg
        195                 200                 205             
Arg Thr Ala Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn
    210                 215                 220                 
Pro Arg Ala Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln
225                 230                 235                 240 
Ser Gln Met Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser
                245                 250                 255     
Tyr Asp Gln Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val
            260                 265                 270         
His Pro Ala Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr
        275                 280                 285             
Leu Ser Ala Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr
    290                 295                 300                 
Ala Phe Ser Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp
305                 310                 315                 320 
Pro Arg Met His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val
                325                 330                 335     
Thr Ser Gly Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg
            340                 345                 350         
Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln
        355                 360                 365             
Gly Gly Pro Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly
    370                 375                 380                 
Ala Ser Ala Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser
385                 390                 395                 400 
Pro Pro Arg Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Phe Ala
                405                 410                 415     
Leu Leu Asn Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu
            420                 425                 430         
Gly Ser His Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu
        435                 440                 445             
Glu Glu Ala Val Trp Arg Pro Tyr
    450                 455     


<210> 6722
<211> 250
<212> PRT
<213> Homo sapiens

<400> 6722
Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro
 1               5                  10                  15      
Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly
            20                  25                  30          
Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp
        35                  40                  45              
Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg
    50                  55                  60                  
Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg
65                  70                  75                  80  
Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp
                85                  90                  95      
Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn
            100                 105                 110         
Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val
        115                 120                 125             
Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys
    130                 135                 140                 
Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala
145                 150                 155                 160 
Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro
                165                 170                 175     
Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu
            180                 185                 190         
Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala
        195                 200                 205             
Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala
    210                 215                 220                 
Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met
225                 230                 235                 240 
Gln Glu Glu Asp Thr Ala Pro Trp Arg Cys
                245                 250 


<210> 6723
<211> 1436
<212> PRT
<213> Homo sapiens

<400> 6723
Met Ala Gln Cys Val Gln Ser Val Gln Glu Leu Ile Pro Asp Ser Phe
 1               5                  10                  15      
Val Pro Cys Val Ala Ala Leu Cys Ser Asp Glu Ala Glu Arg Leu Thr
            20                  25                  30          
Arg Leu Asn His Leu Ser Phe Ala Glu Leu Leu Lys Pro Phe Ser Arg
        35                  40                  45              
Leu Thr Ser Glu Val His Met Arg Asp Pro Asn Asn Gln Leu His Val
    50                  55                  60                  
Ile Lys Asn Leu Lys Ile Ala Val Ser Asn Ile Val Thr Gln Pro Pro
65                  70                  75                  80  
Gln Pro Gly Ala Ile Arg Lys Leu Leu Asn Asp Val Val Ser Gly Ser
                85                  90                  95      
Gln Pro Ala Glu Gly Leu Val Ala Asn Val Ile Thr Ala Gly Asp Tyr
            100                 105                 110         
Asp Leu Asn Ile Ser Ala Thr Thr Pro Trp Phe Glu Ser Tyr Arg Glu
        115                 120                 125             
Thr Phe Leu Gln Ser Met Pro Ala Leu Asp His Glu Phe Leu Asn His
    130                 135                 140                 
Tyr Leu Ala Cys Met Leu Val Ala Ser Ser Ser Glu Ala Glu Pro Val
145                 150                 155                 160 
Glu Gln Phe Ser Lys Leu Ser Gln Glu Gln His Arg Ile Gln His Asn
                165                 170                 175     
Ser Asp Tyr Ser Tyr Pro Lys Trp Phe Ile Pro Asn Thr Leu Lys Tyr
            180                 185                 190         
Tyr Val Leu Leu His Asp Val Ser Ala Gly Asp Glu Gln Arg Ala Glu
        195                 200                 205             
Ser Ile Tyr Glu Glu Met Lys Gln Lys Tyr Gly Thr Gln Gly Cys Tyr
    210                 215                 220                 
Leu Leu Lys Ile Asn Ser Arg Thr Ser Asn Arg Ala Ser Asp Glu Gln
225                 230                 235                 240 
Ile Pro Asp Pro Trp Ser Gln Tyr Leu Gln Lys Asn Ser Ile Gln Asn
                245                 250                 255     
Gln Glu Ser Tyr Glu Asp Gly Pro Cys Thr Ile Thr Ser Asn Lys Asn
            260                 265                 270         
Ser Asp Asn Asn Leu Leu Ser Leu Asp Gly Leu Asp Asn Glu Val Lys
        275                 280                 285             
Val Asp Gly Leu Pro Asn Asn Phe Arg Ala His Pro Leu Gln Leu Glu
    290                 295                 300                 
Gln Ser Ser Asp Pro Ser Asn Ser Ile Asp Gly Pro Asp His Leu Arg
305                 310                 315                 320 
Ser Ala Ser Ser Leu His Glu Thr Lys Lys Gly Asn Thr Gly Ile Ile
                325                 330                 335     
His Gly Ala Cys Leu Thr Leu Thr Asp His Asp Arg Ile Arg Gln Phe
            340                 345                 350         
Ile Gln Glu Phe Thr Phe Arg Gly Leu Leu Pro His Ile Glu Lys Thr
        355                 360                 365             
Ile Arg Gln Leu Asn Asp Gln Leu Ile Ser Arg Lys Gly Leu Ser Arg
    370                 375                 380                 
Ser Leu Phe Ser Ala Thr Lys Lys Trp Phe Ser Gly Ser Lys Val Pro
385                 390                 395                 400 
Glu Lys Ser Ile Asn Asp Leu Lys Asn Thr Ser Gly Leu Leu Tyr Pro
                405                 410                 415     
Pro Glu Ala Pro Glu Leu Gln Ile Arg Lys Met Ala Asp Leu Cys Phe
            420                 425                 430         
Leu Val Gln His Tyr Asp Leu Ala Tyr Ser Cys Tyr His Thr Ala Lys
        435                 440                 445             
Lys Asp Phe Leu Asn Asp Gln Ala Met Leu Tyr Ala Ala Gly Ala Leu
    450                 455                 460                 
Glu Met Ala Ala Val Ser Ala Phe Leu Gln Pro Gly Ala Pro Arg Pro
465                 470                 475                 480 
Tyr Pro Ala His Tyr Met Asp Thr Ala Ile Gln Thr Tyr Arg Asp Ile
                485                 490                 495     
Cys Lys Asn Met Val Leu Ala Glu Arg Cys Val Leu Leu Ser Ala Glu
            500                 505                 510         
Leu Leu Lys Ser Gln Ser Lys Tyr Ser Glu Ala Ala Ala Leu Leu Ile
        515                 520                 525             
Arg Leu Thr Ser Glu Asp Ser Asp Leu Arg Ser Ala Leu Leu Leu Glu
    530                 535                 540                 
Gln Ala Ala His Cys Phe Ile Asn Met Lys Ser Pro Met Val Arg Lys
545                 550                 555                 560 
Tyr Ala Phe His Met Ile Leu Ala Gly His Arg Phe Ser Lys Ala Gly
                565                 570                 575     
Gln Lys Lys His Ala Leu Arg Cys Tyr Cys Gln Ala Met Gln Val Tyr
            580                 585                 590         
Lys Gly Lys Gly Trp Ser Leu Ala Glu Asp His Ile Asn Phe Thr Ile
        595                 600                 605             
Gly Arg Gln Ser Tyr Thr Leu Arg Gln Leu Asp Asn Ala Val Ser Ala
    610                 615                 620                 
Phe Arg His Ile Leu Ile Asn Glu Ser Lys Gln Ser Ala Ala Gln Gln
625                 630                 635                 640 
Gly Ala Phe Leu Arg Glu Tyr Leu Tyr Val Tyr Lys Asn Val Ser Gln
                645                 650                 655     
Leu Ser Pro Asp Gly Pro Leu Pro Gln Leu Pro Leu Pro Tyr Ile Asn
            660                 665                 670         
Ser Ser Ala Thr Arg Val Phe Phe Gly His Asp Arg Arg Pro Ala Asp
        675                 680                 685             
Gly Glu Lys Gln Ala Ala Thr His Val Ser Leu Asp Gln Glu Tyr Asp
    690                 695                 700                 
Ser Glu Ser Ser Gln Gln Trp Arg Glu Leu Glu Glu Gln Val Val Ser
705                 710                 715                 720 
Val Val Asn Lys Gly Val Ile Pro Ser Asn Phe His Pro Thr Gln Tyr
                725                 730                 735     
Cys Leu Asn Ser Tyr Ser Asp Asn Ser Arg Phe Pro Leu Ala Val Val
            740                 745                 750         
Glu Glu Pro Ile Thr Val Glu Val Ala Phe Arg Asn Pro Leu Lys Val
        755                 760                 765             
Leu Leu Leu Leu Thr Asp Leu Ser Leu Leu Trp Lys Phe His Pro Lys
    770                 775                 780                 
Asp Phe Ser Gly Lys Asp Asn Glu Glu Val Lys Gln Leu Val Thr Ser
785                 790                 795                 800 
Glu Pro Glu Met Ile Gly Ala Glu Val Ile Ser Glu Phe Leu Ile Asn
                805                 810                 815     
Gly Glu Glu Ser Lys Val Ala Arg Leu Lys Leu Phe Pro His His Ile
            820                 825                 830         
Gly Glu Leu His Ile Leu Gly Val Val Tyr Asn Leu Gly Thr Ile Gln
        835                 840                 845             
Gly Ser Met Thr Val Asp Gly Ile Gly Ala Leu Pro Gly Cys His Thr
    850                 855                 860                 
Gly Lys Tyr Ser Leu Ser Met Ser Val Arg Gly Lys Gln Asp Leu Glu
865                 870                 875                 880 
Ile Gln Gly Pro Arg Leu Asn Asn Thr Lys Glu Glu Lys Thr Ser Val
                885                 890                 895     
Lys Tyr Gly Pro Asp Arg Arg Leu Asp Pro Ile Ile Thr Glu Glu Met
            900                 905                 910         
Pro Leu Leu Glu Val Phe Phe Ile His Phe Pro Thr Gly Leu Leu Cys
        915                 920                 925             
Gly Glu Ile Arg Lys Ala Tyr Val Glu Phe Val Asn Val Ser Lys Cys
    930                 935                 940                 
Pro Leu Thr Gly Leu Lys Val Val Ser Lys Arg Pro Glu Phe Phe Thr
945                 950                 955                 960 
Phe Gly Gly Asn Thr Ala Val Leu Thr Pro Leu Ser Pro Ser Ala Ser
                965                 970                 975     
Glu Asn Cys Ser Ala Tyr Lys Thr Val Val Thr Asp Ala Thr Ser Val
            980                 985                 990         
Cys Thr Ala Leu Ile Ser Ser Ala Ser Ser Val Asp Phe Gly Ile Gly
        995                 1000                1005            
Thr Gly Ser Gln Pro Glu Val Ile Pro Val Pro Leu Pro Asp Thr Val
    1010                1015                1020                
Leu Leu Pro Gly Ala Ser Val Gln Leu Pro Met Trp Leu Arg Gly Pro
1025                1030                1035                1040
Asp Glu Glu Gly Val His Glu Ile Asn Phe Leu Phe Tyr Tyr Glu Ser
                1045                1050                1055    
Val Lys Lys Gln Pro Lys Ile Arg His Arg Ile Leu Arg His Thr Ala
            1060                1065                1070        
Ile Ile Cys Thr Ser Arg Ser Leu Asn Val Arg Ala Thr Val Cys Arg
        1075                1080                1085            
Ser Asn Ser Leu Glu Asn Glu Glu Gly Arg Gly Gly Asn Met Leu Val
    1090                1095                1100                
Phe Val Asp Val Glu Asn Thr Asn Thr Ser Glu Ala Gly Val Lys Glu
1105                1110                1115                1120
Phe His Ile Val Gln Val Ser Ser Ser Ser Lys His Trp Lys Leu Gln
                1125                1130                1135    
Lys Ser Val Asn Leu Ser Glu Asn Lys Asp Thr Lys Leu Ala Ser Arg
            1140                1145                1150        
Glu Lys Gly Lys Phe Cys Phe Lys Ala Ile Arg Cys Glu Lys Glu Glu
        1155                1160                1165            
Ala Ala Thr Gln Ser Ser Glu Lys Tyr Thr Phe Ala Asp Ile Ile Phe
    1170                1175                1180                
Gly Asn Glu Gln Ile Ile Ser Ser Ala Ser Pro Cys Ala Asp Phe Phe
1185                1190                1195                1200
Tyr Arg Ser Leu Ser Ser Glu Leu Lys Lys Pro Gln Ala His Leu Pro
                1205                1210                1215    
Val His Thr Glu Lys Gln Ser Thr Glu Asp Ala Val Arg Leu Ile Gln
            1220                1225                1230        
Lys Cys Ser Glu Val Asp Leu Asn Ile Val Ile Leu Trp Lys Ala Tyr
        1235                1240                1245            
Val Val Glu Asp Ser Lys Gln Leu Ile Leu Glu Gly Gln His His Val
    1250                1255                1260                
Ile Leu Arg Thr Ile Gly Lys Glu Ala Phe Ser Tyr Pro Gln Lys Gln
1265                1270                1275                1280
Glu Pro Pro Glu Met Glu Leu Leu Lys Phe Phe Arg Pro Glu Asn Ile
                1285                1290                1295    
Thr Val Ser Ser Arg Pro Ser Val Glu Gln Leu Ser Ser Leu Ile Lys
            1300                1305                1310        
Thr Ser Leu His Tyr Pro Glu Ser Phe Asn His Pro Phe His Gln Lys
        1315                1320                1325            
Ser Leu Cys Leu Val Pro Val Thr Leu Leu Leu Ser Asn Cys Ser Lys
    1330                1335                1340                
Ala Asp Val Asp Val Ile Val Asp Leu Arg His Lys Thr Thr Ser Pro
1345                1350                1355                1360
Glu Ala Leu Glu Ile His Gly Ser Phe Thr Trp Leu Gly Gln Thr Gln
                1365                1370                1375    
Tyr Lys Leu Gln Leu Lys Ser Gln Glu Ile His Ser Leu Gln Leu Lys
            1380                1385                1390        
Ala Cys Phe Val His Thr Gly Val Tyr Asn Leu Gly Thr Pro Arg Val
        1395                1400                1405            
Phe Ala Lys Leu Ser Asp Gln Val Thr Val Phe Glu Thr Ser Gln Gln
    1410                1415                1420                
Asn Ser Met Pro Ala Leu Ile Ile Ile Ser Asn Val
1425                1430                1435    


<210> 6724
<211> 1348
<212> PRT
<213> Homo sapiens

<400> 6724
Met Ala Gln Cys Val Gln Ser Val Gln Glu Leu Ile Pro Asp Ser Phe
 1               5                  10                  15      
Val Pro Cys Val Ala Ala Leu Cys Ser Asp Glu Ala Glu Arg Leu Thr
            20                  25                  30          
Arg Leu Asn His Leu Ser Phe Ala Glu Leu Leu Lys Pro Phe Ser Arg
        35                  40                  45              
Leu Thr Ser Glu Val His Met Arg Asp Pro Asn Asn Gln Leu His Val
    50                  55                  60                  
Ile Lys Asn Leu Lys Ile Ala Val Ser Asn Ile Val Thr Gln Pro Pro
65                  70                  75                  80  
Gln Pro Gly Ala Ile Arg Lys Leu Leu Asn Asp Val Val Ser Gly Ser
                85                  90                  95      
Gln Pro Ala Glu Gly Leu Val Ala Asn Val Ile Thr Ala Gly Asp Tyr
            100                 105                 110         
Asp Leu Asn Ile Ser Ala Thr Thr Pro Trp Phe Glu Ser Tyr Arg Glu
        115                 120                 125             
Thr Phe Leu Gln Ser Met Pro Ala Ser Asp His Glu Phe Leu Asn His
    130                 135                 140                 
Tyr Leu Ala Cys Met Leu Val Ala Ser Ser Ser Glu Ala Glu Pro Val
145                 150                 155                 160 
Glu Gln Phe Ser Lys Leu Ser Gln Glu Gln His Arg Ile Gln His Asn
                165                 170                 175     
Ser Asp Tyr Ser Tyr Pro Lys Trp Phe Ile Pro Asn Thr Leu Lys Tyr
            180                 185                 190         
Tyr Val Leu Leu His Asp Val Ser Ala Gly Asp Glu Gln Arg Ala Glu
        195                 200                 205             
Ser Ile Tyr Glu Glu Met Lys Gln Lys Tyr Gly Thr Gln Gly Cys Tyr
    210                 215                 220                 
Leu Leu Lys Ile Asn Ser Arg Thr Ser Asn Arg Ala Ser Asp Glu Gln
225                 230                 235                 240 
Ile Pro Asp Pro Trp Ser Gln Tyr Leu Gln Lys Asn Ser Ile Gln Asn
                245                 250                 255     
Gln Glu Ser Tyr Glu Asp Gly Pro Cys Thr Ile Thr Ser Asn Lys Asn
            260                 265                 270         
Ser Asp Asn Asn Leu Leu Ser Leu Asp Gly Leu Asp Asn Glu Val Lys
        275                 280                 285             
Asp Gly Leu Pro Asn Asn Phe Arg Ala His Pro Leu Gln Leu Glu Gln
    290                 295                 300                 
Ser Ser Asp Pro Ser Asn Ser Ile Asp Gly Pro Asp His Leu Arg Ser
305                 310                 315                 320 
Ala Ser Ser Leu His Glu Thr Lys Lys Gly Asn Thr Gly Ile Ile His
                325                 330                 335     
Gly Ala Cys Leu Thr Leu Thr Asp His Asp Arg Ile Arg Gln Phe Ile
            340                 345                 350         
Gln Glu Phe Thr Phe Arg Gly Leu Leu Pro His Ile Glu Lys Thr Ile
        355                 360                 365             
Arg Gln Leu Asn Asp Gln Leu Ile Ser Arg Lys Gly Leu Ser Arg Ser
    370                 375                 380                 
Leu Phe Ser Ala Thr Lys Lys Trp Phe Ser Gly Ser Lys Val Pro Glu
385                 390                 395                 400 
Lys Ser Ile Asn Asp Leu Lys Asn Thr Ser Gly Leu Leu Tyr Pro Pro
                405                 410                 415     
Glu Ala Pro Glu Leu Gln Ile Arg Lys Met Ala Asp Leu Cys Phe Leu
            420                 425                 430         
Val Gln His Tyr Asp Leu Ala Tyr Ser Cys Tyr His Thr Ala Lys Lys
        435                 440                 445             
Asp Phe Leu Asn Asp Gln Ala Met Leu Tyr Ala Ala Gly Ala Leu Glu
    450                 455                 460                 
Met Ala Ala Val Ser Ala Phe Leu Gln Pro Gly Ala Pro Arg Pro Tyr
465                 470                 475                 480 
Pro Ala His Tyr Met Asp Thr Ala Ile Gln Thr Tyr Arg Asp Ile Cys
                485                 490                 495     
Lys Asn Met Val Leu Ala Glu Arg Cys Val Leu Leu Ser Ala Glu Leu
            500                 505                 510         
Leu Lys Ser Gln Ser Lys Tyr Ser Glu Ala Ala Ala Leu Leu Ile Arg
        515                 520                 525             
Leu Thr Ser Glu Asp Ser Asp Leu Arg Ser Ala Leu Leu Leu Glu Gln
    530                 535                 540                 
Ala Ala His Cys Phe Ile Asn Met Lys Ser Pro Met Val Arg Lys Tyr
545                 550                 555                 560 
Ala Phe His Met Ile Leu Ala Gly His Arg Phe Ser Lys Ala Gly Gln
                565                 570                 575     
Lys Lys His Ala Leu Arg Cys Tyr Cys Gln Ala Met Gln Val Tyr Lys
            580                 585                 590         
Gly Lys Gly Trp Ser Leu Ala Glu Asp His Ile Asn Phe Thr Ile Gly
        595                 600                 605             
Arg Gln Ser Tyr Thr Leu Arg Gln Leu Asp Asn Ala Val Ser Ala Phe
    610                 615                 620                 
Arg His Ile Leu Ile Asn Glu Ser Lys Gln Ser Ala Ala Gln Gln Gly
625                 630                 635                 640 
Ala Phe Leu Arg Glu Tyr Leu Tyr Val Tyr Lys Asn Val Ser Gln Leu
                645                 650                 655     
Ser Pro Asp Gly Pro Leu Pro Gln Leu Pro Leu Pro Tyr Ile Asn Ser
            660                 665                 670         
Ser Ala Thr Arg Val Phe Phe Gly His Asp Arg Arg Pro Ala Asp Gly
        675                 680                 685             
Glu Lys Gln Ala Ala Thr His Val Ser Leu Asp Gln Glu Tyr Asp Ser
    690                 695                 700                 
Glu Ser Ser Gln Gln Trp Arg Glu Leu Glu Glu Gln Val Val Ser Val
705                 710                 715                 720 
Val Asn Lys Gly Val Ile Pro Ser Asn Phe His Pro Thr Gln Tyr Cys
                725                 730                 735     
Leu Asn Ser Tyr Ser Asp Asn Ser Arg Phe Pro Leu Ala Val Val Glu
            740                 745                 750         
Glu Pro Ile Thr Val Glu Val Ala Phe Arg Asn Pro Leu Lys Val Leu
        755                 760                 765             
Leu Leu Leu Thr Asp Leu Ser Leu Leu Trp Lys Phe His Pro Lys Asp
    770                 775                 780                 
Phe Ser Gly Lys Asp Asn Glu Glu Val Lys Gln Leu Val Thr Ser Glu
785                 790                 795                 800 
Pro Glu Met Ile Gly Ala Glu Val Ile Ser Glu Phe Leu Ile Asn Gly
                805                 810                 815     
Glu Glu Ser Lys Val Ala Arg Leu Lys Leu Phe Pro His His Ile Gly
            820                 825                 830         
Glu Leu His Ile Leu Gly Val Val Tyr Asn Leu Gly Thr Ile Gln Gly
        835                 840                 845             
Ser Met Thr Val Asp Gly Ile Gly Ala Leu Pro Gly Cys His Thr Gly
    850                 855                 860                 
Lys Tyr Ser Leu Ser Met Ser Val Arg Gly Lys Gln Asp Leu Glu Ile
865                 870                 875                 880 
Gln Gly Pro Arg Leu Asn Asn Thr Lys Glu Glu Lys Thr Ser Val Lys
                885                 890                 895     
Tyr Gly Pro Asp Arg Arg Leu Asp Pro Ile Ile Thr Glu Glu Met Pro
            900                 905                 910         
Leu Leu Glu Asp Phe Gly Ile Gly Thr Gly Ser Gln Pro Glu Val Ile
        915                 920                 925             
Pro Val Pro Leu Pro Asp Thr Val Leu Leu Pro Gly Ala Ser Val Gln
    930                 935                 940                 
Leu Pro Met Trp Leu Arg Gly Pro Asp Glu Glu Gly Val His Glu Ile
945                 950                 955                 960 
Asn Phe Leu Phe Tyr Tyr Glu Ser Val Lys Lys Gln Pro Lys Ile Arg
                965                 970                 975     
His Arg Ile Leu Arg His Thr Ala Ile Ile Cys Thr Ser Arg Ser Leu
            980                 985                 990         
Asn Val Arg Ala Thr Val Cys Arg Ser Asn Ser Leu Glu Asn Glu Glu
        995                 1000                1005            
Gly Arg Gly Gly Asn Met Leu Val Phe Val Asp Val Glu Asn Thr Asn
    1010                1015                1020                
Thr Ser Glu Ala Gly Val Lys Glu Phe His Ile Val Gln Val Ser Ser
1025                1030                1035                1040
Ser Ser Lys His Trp Lys Leu Gln Lys Ser Val Asn Leu Ser Glu Asn
                1045                1050                1055    
Lys Asp Ala Lys Leu Ala Ser Arg Glu Lys Gly Lys Phe Cys Phe Lys
            1060                1065                1070        
Ala Ile Arg Cys Glu Lys Glu Glu Ala Ala Thr Gln Ser Ser Glu Lys
        1075                1080                1085            
Tyr Thr Phe Ala Asp Ile Ile Phe Gly Asn Glu Gln Ile Ile Ser Ser
    1090                1095                1100                
Ala Ser Pro Cys Ala Asp Phe Phe Tyr Arg Ser Leu Ser Ser Glu Leu
1105                1110                1115                1120
Lys Lys Pro Gln Ala His Leu Pro Val His Thr Glu Lys Gln Ser Thr
                1125                1130                1135    
Glu Asp Ala Val Arg Leu Ile Gln Lys Cys Ser Glu Val Asp Leu Asn
            1140                1145                1150        
Ile Val Ile Leu Trp Lys Ala Tyr Val Val Glu Asp Ser Lys Gln Leu
        1155                1160                1165            
Ile Leu Glu Gly Gln His His Val Ile Leu Arg Thr Ile Gly Lys Glu
    1170                1175                1180                
Ala Phe Ser Tyr Pro Gln Lys Gln Glu Pro Pro Glu Met Glu Leu Leu
1185                1190                1195                1200
Lys Phe Phe Arg Pro Glu Asn Ile Thr Val Ser Ser Arg Pro Ser Val
                1205                1210                1215    
Glu Gln Leu Ser Ser Leu Ile Lys Thr Ser Leu His Tyr Pro Glu Ser
            1220                1225                1230        
Phe Asn His Pro Phe His Gln Lys Ser Leu Cys Leu Val Pro Val Thr
        1235                1240                1245            
Leu Leu Leu Ser Asn Cys Ser Lys Ala Asp Val Asp Val Ile Val Asp
    1250                1255                1260                
Leu Arg His Lys Thr Thr Ser Pro Glu Ala Leu Glu Ile His Gly Ser
1265                1270                1275                1280
Phe Thr Trp Leu Gly Gln Thr Gln Tyr Lys Leu Gln Leu Lys Ser Gln
                1285                1290                1295    
Glu Ile His Ser Leu Gln Leu Lys Ala Cys Phe Val His Thr Gly Val
            1300                1305                1310        
Tyr Asn Leu Gly Thr Pro Arg Val Phe Ala Lys Leu Ser Asp Gln Val
        1315                1320                1325            
Thr Val Phe Glu Thr Ser Gln Gln Asn Ser Met Pro Ala Leu Ile Ile
    1330                1335                1340                
Ile Ser Asn Val
1345            


<210> 6725
<211> 462
<212> PRT
<213> Homo sapiens

<400> 6725
Met Asp Lys Asp Ser Gln Gly Leu Leu Asp Ser Ser Leu Met Ala Ser
 1               5                  10                  15      
Gly Thr Ala Ser Arg Ser Glu Asp Glu Glu Ser Leu Ala Gly Gln Lys
            20                  25                  30          
Arg Ala Ser Ser Gln Ala Leu Gly Thr Ile Pro Lys Arg Arg Ser Ser
        35                  40                  45              
Ser Arg Phe Ile Lys Arg Lys Lys Phe Asp Asp Glu Leu Val Glu Ser
    50                  55                  60                  
Ser Leu Ala Lys Ser Ser Thr Arg Ala Lys Gly Ala Ser Gly Val Glu
65                  70                  75                  80  
Pro Gly Arg Cys Ser Gly Ser Glu Pro Ser Ser Ser Glu Lys Lys Lys
                85                  90                  95      
Val Ser Lys Ala Pro Ser Thr Pro Val Pro Pro Ser Pro Ala Pro Ala
            100                 105                 110         
Pro Gly Leu Thr Lys Arg Val Lys Lys Ser Lys Gln Pro Leu Gln Val
        115                 120                 125             
Thr Lys Asp Leu Gly Arg Trp Lys Pro Ala Asp Asp Leu Leu Leu Ile
    130                 135                 140                 
Asn Ala Val Leu Gln Thr Asn Asp Leu Thr Ser Val His Leu Gly Val
145                 150                 155                 160 
Lys Phe Ser Cys Arg Phe Thr Leu Arg Glu Val Gln Glu Arg Trp Tyr
                165                 170                 175     
Ala Leu Leu Tyr Asp Pro Val Ile Ser Lys Leu Ala Cys Gln Ala Met
            180                 185                 190         
Arg Gln Leu His Pro Glu Ala Ile Ala Ala Ile Gln Ser Lys Ala Leu
        195                 200                 205             
Phe Ser Lys Ala Glu Glu Gln Leu Leu Ser Lys Val Gly Ser Thr Ser
    210                 215                 220                 
Gln Pro Thr Leu Glu Thr Phe Gln Asp Leu Leu His Arg His Pro Asp
225                 230                 235                 240 
Ala Phe Tyr Leu Ala Arg Thr Ala Lys Ala Leu Gln Ala His Trp Gln
                245                 250                 255     
Leu Met Lys Gln Tyr Tyr Leu Leu Glu Asp Gln Thr Val Gln Pro Leu
            260                 265                 270         
Pro Lys Gly Asp Gln Val Leu Asn Phe Ser Asp Ala Glu Asp Leu Ile
        275                 280                 285             
Asp Asp Ser Lys Leu Lys Asp Met Arg Asp Glu Val Leu Glu His Glu
    290                 295                 300                 
Leu Met Val Ala Asp Arg Arg Gln Lys Arg Glu Ile Arg Gln Leu Glu
305                 310                 315                 320 
Gln Glu Leu His Lys Trp Gln Val Leu Val Asp Ser Ile Thr Gly Met
                325                 330                 335     
Ser Ser Pro Asp Phe Asp Asn Gln Thr Leu Ala Val Leu Arg Gly Arg
            340                 345                 350         
Met Val Arg Tyr Leu Met Arg Ser Arg Glu Ile Thr Leu Gly Arg Ala
        355                 360                 365             
Thr Lys Asp Asn Gln Ile Asp Val Asp Leu Ser Leu Glu Gly Pro Ala
    370                 375                 380                 
Trp Lys Ile Ser Arg Lys Gln Gly Val Ile Lys Leu Lys Asn Asn Gly
385                 390                 395                 400 
Asp Phe Phe Ile Ala Asn Glu Gly Arg Arg Pro Ile Tyr Ile Asp Gly
                405                 410                 415     
Arg Pro Val Leu Cys Gly Ser Lys Trp Arg Leu Ser Asn Asn Ser Val
            420                 425                 430         
Val Glu Ile Ala Ser Leu Arg Phe Val Phe Leu Ile Asn Gln Asp Leu
        435                 440                 445             
Ile Ala Leu Ile Arg Ala Glu Ala Ala Lys Ile Thr Pro Gln
    450                 455                 460         


<210> 6726
<211> 2715
<212> PRT
<213> Homo sapiens

<400> 6726
Met Lys Met Lys Ile Gln Lys Lys Glu Lys Gln Leu Ser Asn Leu Lys
 1               5                  10                  15      
Val Leu Asn His Ser Pro Met Ser Asp Ala Ser Val Asn Phe Asp Tyr
            20                  25                  30          
Lys Ser Pro Ser Pro Phe Asp Cys Ser Thr Asp Gln Glu Glu Lys Ile
        35                  40                  45              
Glu Asp Val Ala Ser His Cys Leu Pro Gln Lys Asp Leu Tyr Thr Ala
    50                  55                  60                  
Glu Glu Glu Ala Ala Thr Leu Phe Pro Arg Lys Met Thr Ser His Asn
65                  70                  75                  80  
Gly Met Glu Asp Ser Gly Gly Gly Gly Thr Gly Val Lys Lys Lys Arg
                85                  90                  95      
Lys Lys Lys Glu Pro Gly Asp Gln Glu Gly Ala Ala Lys Gly Ser Lys
            100                 105                 110         
Asp Arg Glu Pro Lys Pro Lys Arg Lys Arg Glu Pro Lys Glu Pro Lys
        115                 120                 125             
Glu Pro Arg Lys Ala Lys Glu Pro Lys Lys Ala Lys Glu His Lys Glu
    130                 135                 140                 
Pro Lys Gln Lys Asp Gly Ala Lys Lys Ala Arg Lys Pro Arg Glu Ala
145                 150                 155                 160 
Ser Gly Thr Lys Glu Ala Lys Glu Lys Arg Ser Cys Thr Asp Ser Ala
                165                 170                 175     
Ala Arg Thr Lys Ser Arg Lys Ala Ser Lys Glu Gln Gly Pro Thr Pro
            180                 185                 190         
Val Glu Lys Lys Lys Lys Gly Lys Arg Lys Ser Glu Thr Thr Val Glu
        195                 200                 205             
Ser Leu Glu Leu Asp Gln Gly Leu Thr Asn Pro Ser Leu Arg Ser Pro
    210                 215                 220                 
Glu Glu Ser Thr Glu Ser Thr Asp Ser Gln Lys Arg Arg Ser Gly Arg
225                 230                 235                 240 
Gln Val Lys Arg Arg Lys Tyr Asn Glu Asp Leu Asp Phe Lys Val Val
                245                 250                 255     
Asp Asp Asp Gly Glu Thr Ile Ala Val Leu Gly Ala Gly Arg Thr Ser
            260                 265                 270         
Ala Leu Ser Ala Ser Thr Leu Ala Trp Gln Ala Glu Glu Pro Pro Glu
        275                 280                 285             
Asp Asp Ala Asn Ile Ile Glu Lys Ile Leu Ala Ser Lys Thr Val Gln
    290                 295                 300                 
Glu Val His Pro Gly Glu Pro Pro Phe Asp Leu Glu Leu Phe Tyr Val
305                 310                 315                 320 
Lys Tyr Arg Asn Phe Ser Tyr Leu His Cys Lys Trp Ala Thr Met Glu
                325                 330                 335     
Glu Leu Glu Lys Asp Pro Arg Ile Ala Gln Lys Ile Lys Arg Phe Arg
            340                 345                 350         
Asn Lys Gln Ala Gln Met Lys His Ile Phe Thr Glu Pro Asp Glu Asp
        355                 360                 365             
Leu Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Glu Val Ala
    370                 375                 380                 
His Thr Lys Asp Ala Glu Thr Gly Glu Glu Val Thr His Tyr Leu Val
385                 390                 395                 400 
Lys Trp Cys Ser Leu Pro Tyr Glu Glu Ser Thr Trp Glu Leu Glu Glu
                405                 410                 415     
Asp Val Asp Pro Ala Lys Val Lys Glu Phe Glu Ser Leu Gln Val Leu
            420                 425                 430         
Pro Glu Ile Lys His Val Glu Arg Pro Ala Ser Asp Ser Trp Gln Lys
        435                 440                 445             
Leu Glu Lys Ser Arg Glu Tyr Lys Asn Ser Asn Gln Leu Arg Glu Tyr
    450                 455                 460                 
Gln Leu Glu Gly Met Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Lys
465                 470                 475                 480 
Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ser
                485                 490                 495     
Ile Thr Phe Leu Ser Glu Ile Phe Leu Arg Gly Ile His Gly Pro Phe
            500                 505                 510         
Leu Ile Ile Ala Pro Leu Ser Thr Ile Thr Asn Trp Glu Arg Glu Phe
        515                 520                 525             
Arg Thr Trp Thr Glu Met Asn Ala Ile Val Tyr His Gly Ser Gln Ile
    530                 535                 540                 
Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Val Tyr Arg Asp Ala Gln
545                 550                 555                 560 
Gly Asn Pro Leu Ser Gly Val Phe Lys Phe His Val Val Ile Thr Thr
                565                 570                 575     
Phe Glu Met Ile Leu Ala Asp Cys Pro Glu Leu Lys Lys Ile His Trp
            580                 585                 590         
Ser Cys Val Ile Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn Cys
        595                 600                 605             
Lys Leu Leu Glu Gly Leu Lys Leu Met Ala Leu Glu His Lys Val Leu
    610                 615                 620                 
Leu Thr Gly Thr Pro Leu Gln Asn Ser Val Glu Glu Leu Phe Ser Leu
625                 630                 635                 640 
Leu Asn Phe Leu Glu Pro Ser Gln Phe Pro Ser Glu Thr Ala Phe Leu
                645                 650                 655     
Glu Glu Phe Gly Asp Leu Lys Thr Glu Glu Gln Val Lys Lys Leu Gln
            660                 665                 670         
Ser Ile Leu Lys Pro Met Met Leu Arg Arg Leu Lys Asp Asp Val Glu
        675                 680                 685             
Lys Asn Leu Ala Pro Lys Gln Glu Thr Ile Ile Glu Val Glu Leu Thr
    690                 695                 700                 
Asn Ile Gln Lys Lys Tyr Tyr Arg Ala Ile Leu Glu Lys Asn Phe Ser
705                 710                 715                 720 
Phe Leu Thr Lys Gly Ala Asn Gln His Asn Met Pro Asn Leu Ile Asn
                725                 730                 735     
Thr Met Met Glu Leu Arg Lys Cys Cys Asn His Pro Tyr Leu Ile Asn
            740                 745                 750         
Gly Ala Glu Glu Lys Ile Leu Glu Asp Phe Arg Lys Thr His Ser Pro
        755                 760                 765             
Asp Ala Pro Asp Phe Gln Leu Gln Ala Met Ile Gln Ala Ala Gly Lys
    770                 775                 780                 
Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Leu Ile Ala Gly Gly His
785                 790                 795                 800 
Lys Val Leu Ile Phe Ser Gln Met Val Arg Cys Leu Asp Ile Leu Glu
                805                 810                 815     
Asp Tyr Leu Ile Gln Arg Arg Tyr Thr Tyr Glu Arg Ile Asp Gly Arg
            820                 825                 830         
Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp Arg Phe Cys Lys Pro
        835                 840                 845             
Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Thr Arg Ala Gly Gly Leu
    850                 855                 860                 
Gly Ile Asn Leu Thr Ala Ala Asp Thr Cys Ile Ile Phe Asp Ser Asp
865                 870                 875                 880 
Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala Arg Cys His Arg Ile
                885                 890                 895     
Gly Gln Ser Lys Ala Val Lys Val Tyr Arg Leu Ile Thr Arg Asn Ser
            900                 905                 910         
Tyr Glu Arg Glu Met Phe Asp Lys Ala Ser Leu Lys Leu Gly Leu Asp
        915                 920                 925             
Lys Ala Val Leu Gln Asp Ile Asn Arg Lys Gly Gly Thr Asn Gly Val
    930                 935                 940                 
Gln Gln Leu Ser Lys Met Glu Val Glu Asp Leu Leu Arg Lys Gly Ala
945                 950                 955                 960 
Tyr Gly Ala Leu Met Asp Glu Glu Asp Glu Gly Ser Lys Phe Cys Glu
                965                 970                 975     
Glu Asp Ile Asp Gln Ile Leu Gln Arg Arg Thr His Thr Ile Thr Ile
            980                 985                 990         
Gln Ser Glu Gly Lys Gly Ser Thr Phe Ala Lys Ala Ser Phe Val Ala
        995                 1000                1005            
Ser Gly Asn Arg Thr Asp Ile Ser Leu Asp Asp Pro Asn Phe Trp Gln
    1010                1015                1020                
Lys Trp Ala Lys Ile Ala Glu Leu Asp Thr Glu Ala Lys Asn Glu Lys
1025                1030                1035                1040
Glu Ser Leu Val Ile Asp Arg Pro Arg Val Arg Lys Gln Thr Lys His
                1045                1050                1055    
Tyr Asn Ser Phe Glu Glu Asp Glu Leu Met Glu Phe Ser Glu Leu Asp
            1060                1065                1070        
Ser Asp Ser Asp Glu Arg Pro Thr Arg Ser Arg Arg Leu Asn Asp Lys
        1075                1080                1085            
Ala Arg Arg Tyr Leu Arg Ala Glu Cys Phe Arg Val Glu Lys Asn Leu
    1090                1095                1100                
Leu Ile Phe Gly Trp Gly Arg Trp Lys Asp Ile Leu Thr His Gly Arg
1105                1110                1115                1120
Phe Lys Trp His Leu Asn Glu Lys Asp Met Glu Met Ile Cys Arg Ala
                1125                1130                1135    
Leu Leu Val Tyr Cys Val Lys His Tyr Lys Gly Asp Glu Lys Ile Lys
            1140                1145                1150        
Ser Phe Ile Trp Glu Leu Ile Thr Pro Thr Lys Asp Gly Gln Ala Gln
        1155                1160                1165            
Thr Leu Gln Asn His Ser Gly Leu Ser Ala Pro Val Pro Arg Gly Arg
    1170                1175                1180                
Lys Gly Lys Lys Thr Lys Asn Gln Leu Leu Ile Pro Glu Leu Lys Asp
1185                1190                1195                1200
Ala Asp Trp Leu Ala Thr Cys Asn Pro Glu Val Val Leu His Asp Asp
                1205                1210                1215    
Gly Tyr Lys Lys His Leu Lys Gln His Cys Asn Lys Val Leu Leu Arg
            1220                1225                1230        
Val Arg Met Leu Tyr Tyr Leu Lys Ala Glu Ile Leu Gly Glu Ala Ala
        1235                1240                1245            
Glu Lys Ala Phe Glu Gly Ser Pro Ala Arg Glu Leu Asp Val Pro Leu
    1250                1255                1260                
Pro Asp Ile Asp Tyr Met Glu Ile Pro Val Asp Trp Trp Asp Ala Glu
1265                1270                1275                1280
Ala Asp Lys Ser Leu Leu Ile Gly Val Phe Lys His Gly Tyr Glu Arg
                1285                1290                1295    
Tyr Asn Ala Met Arg Ala Asp Pro Ala Leu Cys Phe Leu Glu Lys Val
            1300                1305                1310        
Gly Met Pro Asp Glu Lys Ser Leu Ser Ala Glu Gln Gly Val Thr Asp
        1315                1320                1325            
Gly Thr Ser Asp Ile Pro Glu Arg Gly Asn Thr Asp Lys Glu Asp Asn
    1330                1335                1340                
Ala Glu Asp Lys Val Asp Gly Leu Gln Lys Gln Thr Glu Ser Ser Ser
1345                1350                1355                1360
Asp Gly Gly Asp Gly Val Phe Ser Glu Lys Lys Asp Asp Ser Arg Ala
                1365                1370                1375    
Ala Gln Asp Gly Ser Asp Pro Asp Lys Ser Pro Trp Pro Val Ser Ser
            1380                1385                1390        
Ala Leu Thr Ala Arg Leu Arg Arg Leu Val Thr Val Tyr Gln Arg Cys
        1395                1400                1405            
Asn Arg Lys Glu Leu Cys Arg Pro Glu Ile Leu Gly Pro Gly Asn Gln
    1410                1415                1420                
Gly Tyr Trp Val Gln Glu Glu Met Phe Arg Arg Thr Ser Glu Met Asp
1425                1430                1435                1440
Leu Ile Asn Lys Glu Ala Gln Lys Arg Trp Thr Arg Arg Glu Gln Ala
                1445                1450                1455    
Asp Phe Tyr Arg Thr Val Ser Ser Phe Gly Val Val Tyr Asp Gln Glu
            1460                1465                1470        
Lys Lys Thr Phe Asp Trp Thr Gln Phe Arg Ile Ile Ser Arg Leu Asp
        1475                1480                1485            
Lys Lys Ser Asp Glu Ser Leu Glu Gln Tyr Phe Tyr Ser Phe Val Ala
    1490                1495                1500                
Met Cys Arg Asn Val Cys Arg Leu Pro Thr Trp Lys Asp Gly Gly Pro
1505                1510                1515                1520
Pro Asp Thr Thr Ile Tyr Val Glu Pro Ile Thr Glu Glu Arg Ala Ala
                1525                1530                1535    
Arg Thr Leu Tyr Arg Ile Glu Leu Leu Arg Lys Val Arg Glu Gln Val
            1540                1545                1550        
Leu Lys Cys Pro Gln Leu His Glu Arg Leu Gln Leu Cys Arg Pro Ser
        1555                1560                1565            
Leu Tyr Leu Pro Val Trp Trp Glu Cys Gly Lys His Asp Arg Asp Leu
    1570                1575                1580                
Leu Ile Gly Thr Ala Lys His Gly Leu Asn Arg Thr Asp Cys Tyr Ile
1585                1590                1595                1600
Met Asn Asp Pro Gln Leu Ser Phe Leu Asp Ala Tyr Arg Asn Tyr Ala
                1605                1610                1615    
Gln His Lys Arg Ser Gly Thr Gln Ala Pro Gly Asn Leu Cys Cys Leu
            1620                1625                1630        
Tyr Gln Thr Asn Ser Lys Leu Tyr Glu Ser Leu Thr Tyr Ser Gln Met
        1635                1640                1645            
Ser Arg Thr Ser Glu Ser Leu Glu Asn Glu Pro Glu Asn Leu Val Arg
    1650                1655                1660                
Val Glu Ser Arg Asp Asp His Leu Ser Leu Pro Asp Val Thr Cys Glu
1665                1670                1675                1680
Asn Phe Ile Ser Lys Val Gln Asp Val Ile Ser Ile Asn His Asp Glu
                1685                1690                1695    
Ser Leu Leu Pro Glu Ser Leu Glu Ser Met Met Tyr Gly Lys Lys Val
            1700                1705                1710        
Leu Ser Gln Glu Pro Ser Ser Phe Gln Glu Ser Pro Ser Thr Asn Thr
        1715                1720                1725            
Glu Ser Arg Lys Asp Val Ile Thr Ile Ser Ile Ser Lys Asp Gly Asn
    1730                1735                1740                
Cys Gln Ser Gly Gly Pro Glu Ala Glu Ile Ala Ser Gly Pro Thr Phe
1745                1750                1755                1760
Met Gly Ser Leu Glu Ala Gly Gly Val Ala Gln Ala Asn Ile Lys Asn
                1765                1770                1775    
Gly Lys His Leu Leu Met Ser Ile Ser Lys Glu Gly Glu Leu Cys Cys
            1780                1785                1790        
Ser Glu Ala Gly Gln Arg Pro Glu Asn Ile Gly Gln Leu Glu Ala Lys
        1795                1800                1805            
Cys Leu Ala Ser Pro Ser Leu Asn Pro Gly Asn Glu Ser Gly Phe Val
    1810                1815                1820                
Asp Met Cys Ser Leu Ser Val Cys Asp Ser Lys Arg Asn Leu Ser Ser
1825                1830                1835                1840
Asp Gln Gln Leu Ile Asp Leu Leu Glu Asn Lys Ser Leu Glu Ser Lys
                1845                1850                1855    
Leu Ile Leu Ser Gln Asn His Ser Asp Glu Glu Glu Glu Glu Glu Glu
            1860                1865                1870        
Asn Glu Glu Glu Asn Leu Ala Met Ala Val Gly Met Gly Glu Arg Pro
        1875                1880                1885            
Glu Val Leu His Leu Thr Glu Pro Thr Thr Asn Ile Ser Arg Glu Lys
    1890                1895                1900                
Asn Gln Gly Phe Gln Asp Glu Thr Lys Lys Gly Ser Leu Glu Val Ala
1905                1910                1915                1920
Asn Gln Thr Pro Gly Leu Gln Arg Ala Phe Pro Ala Pro Ala Ala Cys
                1925                1930                1935    
Gln Cys His Cys Lys His Met Glu Arg Trp Met His Gly Leu Glu Asn
            1940                1945                1950        
Asp Glu Phe Glu Ile Glu Lys Pro Lys Ala Tyr Ile Pro Asp Leu Phe
        1955                1960                1965            
Lys Ser Lys Thr Asn Thr Ile Ala Met Glu Gly Glu Pro Thr Ala Ile
    1970                1975                1980                
Pro Ser Gln Pro Phe Lys Val Lys His Glu Leu Leu Lys Glu Pro Trp
1985                1990                1995                2000
Lys Glu Ser Ala Glu Gly Gln Asn Val Phe Pro Thr Tyr Pro Leu Glu
                2005                2010                2015    
Gly Ser Glu Leu Lys Ser Glu Asp Met Asp Phe Glu Asn Lys Asp Asp
            2020                2025                2030        
Tyr Asp Arg Asp Gly Asn Cys His Ser Gln Asp Tyr Pro Gly Lys Tyr
        2035                2040                2045            
Ser Glu Glu Glu Ser Lys Ser Ser Thr Ser Gly Ile Thr Gly Asp Ile
    2050                2055                2060                
Gly Asp Glu Leu Gln Glu Ala Arg Ala Pro Thr Ile Ala Gln Leu Leu
2065                2070                2075                2080
Gln Glu Lys Thr Leu Tyr Ser Phe Ser Glu Trp Pro Lys Asp Arg Val
                2085                2090                2095    
Ile Ile Asn Arg Leu Asp Asn Ile Cys His Val Val Leu Lys Gly Lys
            2100                2105                2110        
Trp Pro Ser Ser Gln Gln Tyr Glu Pro Ser Gly Thr Leu Pro Thr Pro
        2115                2120                2125            
Val Leu Thr Ser Ser Ala Gly Ser Arg Thr Ser Leu Ser Glu Pro Glu
    2130                2135                2140                
Ala Ala Glu His Ser Phe Ser Asn Gly Ala Ala Leu Ala Ala Gln Ile
2145                2150                2155                2160
His Lys Glu Ser Phe Leu Ala Pro Val Phe Thr Lys Asp Glu Gln Lys
                2165                2170                2175    
His Arg Arg Pro Tyr Glu Phe Glu Val Glu Arg Asp Ala Lys Ala Arg
            2180                2185                2190        
Gly Leu Glu Gln Phe Ser Ala Thr His Gly His Thr Pro Ile Ile Leu
        2195                2200                2205            
Asn Gly Trp His Gly Glu Ser Ala Met Asp Leu Ser Cys Ser Ser Glu
    2210                2215                2220                
Gly Ser Pro Gly Ala Thr Ser Pro Phe Pro Val Ser Ala Ser Thr Pro
2225                2230                2235                2240
Lys Ile Gly Ala Ile Ser Ser Leu Gln Gly Ala Leu Gly Met Asp Leu
                2245                2250                2255    
Ser Gly Ile Leu Gln Ala Gly Leu Ile His Pro Val Thr Gly Gln Ile
            2260                2265                2270        
Val Asn Gly Ser Leu Arg Arg Asp Asp Ala Ala Thr Arg Arg Arg Arg
        2275                2280                2285            
Gly Arg Arg Lys His Val Glu Gly Gly Met Asp Leu Ile Phe Leu Lys
    2290                2295                2300                
Glu Gln Thr Leu Gln Ala Gly Ile Leu Glu Val His Glu Asp Pro Gly
2305                2310                2315                2320
Gln Ala Thr Leu Ser Thr Thr His Pro Glu Gly Pro Gly Pro Ala Thr
                2325                2330                2335    
Ser Ala Pro Glu Pro Ala Thr Ala Ala Ser Ser Gln Ala Glu Lys Ser
            2340                2345                2350        
Ile Pro Ser Lys Ser Leu Leu Asp Trp Leu Arg Gln Gln Ala Asp Tyr
        2355                2360                2365            
Ser Leu Glu Val Pro Gly Phe Gly Ala Asn Phe Ser Asp Lys Pro Lys
    2370                2375                2380                
Gln Arg Arg Pro Arg Cys Lys Glu Pro Gly Lys Leu Asp Val Ser Ser
2385                2390                2395                2400
Leu Ser Gly Glu Glu Arg Val Pro Ala Ile Pro Lys Glu Pro Gly Leu
                2405                2410                2415    
Arg Gly Phe Leu Pro Glu Asn Lys Phe Asn His Thr Leu Ala Glu Pro
            2420                2425                2430        
Ile Leu Arg Asp Thr Gly Pro Arg Arg Arg Gly Arg Arg Pro Arg Ser
        2435                2440                2445            
Glu Leu Leu Lys Ala Pro Ser Ile Val Ala Asp Ser Pro Ser Gly Met
    2450                2455                2460                
Gly Pro Leu Phe Met Asn Gly Leu Ile Ala Gly Met Asp Leu Val Gly
2465                2470                2475                2480
Leu Gln Asn Met Arg Asn Met Pro Gly Ile Pro Leu Thr Gly Leu Val
                2485                2490                2495    
Gly Phe Pro Ala Gly Phe Ala Thr Met Pro Thr Gly Glu Glu Val Lys
            2500                2505                2510        
Ser Thr Leu Ser Met Leu Pro Met Met Leu Pro Gly Met Ala Ala Val
        2515                2520                2525            
Pro Gln Met Phe Gly Val Gly Gly Leu Leu Ser Pro Pro Met Ala Thr
    2530                2535                2540                
Thr Cys Thr Ser Thr Ala Pro Ala Ser Leu Ser Ser Thr Thr Lys Ser
2545                2550                2555                2560
Gly Thr Ala Val Thr Glu Lys Thr Ala Glu Asp Lys Pro Ser Ser His
                2565                2570                2575    
Asp Val Lys Thr Asp Thr Leu Ala Glu Asp Lys Pro Gly Pro Gly Pro
            2580                2585                2590        
Phe Ser Asp Gln Ser Glu Pro Ala Ile Thr Thr Ser Ser Pro Val Ala
        2595                2600                2605            
Phe Asn Pro Phe Leu Ile Pro Gly Val Ser Pro Gly Leu Ile Tyr Pro
    2610                2615                2620                
Ser Met Phe Leu Ser Pro Gly Met Gly Met Ala Leu Pro Ala Met Gln
2625                2630                2635                2640
Gln Ala Arg His Ser Glu Ile Val Gly Leu Glu Ser Gln Lys Arg Lys
                2645                2650                2655    
Lys Lys Lys Thr Lys Gly Asp Asn Pro Asn Ser His Pro Glu Pro Ala
            2660                2665                2670        
Pro Ser Cys Glu Arg Glu Pro Ser Gly Asp Glu Asn Cys Ala Glu Pro
        2675                2680                2685            
Ser Ala Pro Leu Pro Ala Glu Arg Glu His Gly Ala Gln Ala Gly Glu
    2690                2695                2700                
Gly Ala Leu Lys Asp Ser Asn Asn Asp Thr Asn
2705                2710                2715


<210> 6727
<211> 994
<212> PRT
<213> Homo sapiens

<400> 6727
Met Arg Arg Arg Pro Pro Ser Arg Gly Gly Arg Gly Ala Ala Arg Ala
 1               5                  10                  15      
Arg Glu Thr Arg Arg Gln Pro Arg His Arg Ser Gly Arg Arg Met Ala
            20                  25                  30          
Glu Ala Ile Ser Cys Thr Leu Asn Cys Ser Cys Gln Ser Phe Lys Pro
        35                  40                  45              
Gly Lys Ile Asn His Arg Gln Cys Asp Gln Cys Lys His Gly Trp Val
    50                  55                  60                  
Ala His Ala Leu Ser Lys Leu Arg Ile Pro Pro Met Tyr Pro Thr Ser
65                  70                  75                  80  
Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu
                85                  90                  95      
Met Leu Tyr Gly Thr Gln Ala Ile Pro Val Arg Leu Lys Ile Leu Leu
            100                 105                 110         
Asp Arg Leu Phe Ser Val Leu Lys Gln Asp Glu Val Leu Gln Ile Leu
        115                 120                 125             
His Ala Leu Asp Trp Thr Leu Gln Asp Tyr Ile Arg Gly Tyr Val Leu
    130                 135                 140                 
Gln Asp Ala Ser Gly Lys Val Leu Asp His Trp Ser Ile Met Thr Ser
145                 150                 155                 160 
Glu Glu Glu Val Ala Thr Leu Gln Gln Phe Leu Arg Phe Gly Glu Thr
                165                 170                 175     
Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Glu Gln Ser
            180                 185                 190         
Ile Ile Ile Pro Pro Ser Thr Ala Asn Val Asp Ile Arg Ala Phe Ile
        195                 200                 205             
Glu Ser Cys Ser His Arg Ser Ser Ser Leu Pro Thr Pro Val Asp Lys
    210                 215                 220                 
Gly Asn Pro Ser Ser Ile His Pro Phe Glu Asn Leu Ile Ser Asn Met
225                 230                 235                 240 
Thr Phe Met Leu Pro Phe Gln Phe Phe Asn Pro Leu Pro Pro Ala Leu
                245                 250                 255     
Ile Gly Ser Leu Pro Glu Gln Tyr Met Leu Glu Gln Gly His Asp Gln
            260                 265                 270         
Ser Gln Asp Pro Lys Gln Glu Val His Gly Pro Phe Pro Asp Ser Ser
        275                 280                 285             
Phe Leu Thr Ser Ser Ser Thr Pro Phe Gln Val Glu Lys Asp Gln Cys
    290                 295                 300                 
Leu Asn Cys Pro Asp Ala Ile Thr Lys Lys Glu Asp Ser Thr His Leu
305                 310                 315                 320 
Ser Asp Ser Ser Ser Tyr Asn Ile Val Thr Lys Phe Glu Arg Thr Gln
                325                 330                 335     
Leu Ser Pro Glu Ala Lys Val Lys Pro Glu Arg Asn Ser Leu Gly Thr
            340                 345                 350         
Lys Lys Gly Arg Val Phe Cys Thr Ala Cys Glu Lys Thr Phe Tyr Asp
        355                 360                 365             
Lys Gly Thr Leu Lys Ile His Tyr Asn Ala Val His Leu Lys Ile Lys
    370                 375                 380                 
His Lys Cys Thr Ile Glu Gly Cys Asn Met Val Phe Ser Ser Leu Arg
385                 390                 395                 400 
Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg Leu His Met Pro
                405                 410                 415     
Met Asn Arg Asn Asn Arg Asp Lys Asp Leu Arg Asn Ser Leu Asn Leu
            420                 425                 430         
Ala Ser Ser Glu Asn Tyr Lys Cys Pro Gly Phe Thr Val Thr Ser Pro
        435                 440                 445             
Asp Cys Arg Pro Pro Pro Ser Tyr Pro Gly Ser Gly Glu Asp Ser Lys
    450                 455                 460                 
Gly Gln Pro Ala Phe Pro Asn Ile Gly Gln Asn Gly Val Leu Phe Pro
465                 470                 475                 480 
Asn Leu Lys Thr Val Gln Pro Val Leu Pro Phe Tyr Arg Ser Pro Ala
                485                 490                 495     
Thr Pro Ala Glu Val Ala Asn Thr Pro Gly Ile Leu Pro Ser Leu Pro
            500                 505                 510         
Leu Leu Ser Ser Ser Ile Pro Glu Gln Leu Ile Ser Asn Glu Met Pro
        515                 520                 525             
Phe Asp Ala Leu Pro Lys Lys Lys Ser Arg Lys Ser Ser Met Pro Ile
    530                 535                 540                 
Lys Ile Glu Lys Glu Ala Val Glu Ile Ala Asn Glu Lys Arg His Asn
545                 550                 555                 560 
Leu Ser Ser Asp Glu Asp Met Pro Leu Gln Val Val Ser Glu Asp Glu
                565                 570                 575     
Gln Glu Ala Cys Ser Pro Gln Ser His Arg Val Ser Glu Glu Gln His
            580                 585                 590         
Val Gln Ser Gly Gly Leu Gly Lys Pro Phe Pro Glu Gly Glu Arg Pro
        595                 600                 605             
Cys His Arg Glu Ser Val Ile Glu Ser Ser Gly Ala Ile Ser Gln Thr
    610                 615                 620                 
Pro Glu Gln Ala Thr His Asn Ser Glu Arg Glu Thr Glu Gln Thr Pro
625                 630                 635                 640 
Ala Leu Ile Met Val Pro Arg Glu Val Glu Asp Gly Gly His Glu His
                645                 650                 655     
Tyr Phe Thr Pro Gly Met Glu Pro Gln Val Pro Phe Ser Asp Tyr Met
            660                 665                 670         
Glu Leu Gln Gln Arg Leu Leu Ala Gly Gly Leu Phe Ser Ala Leu Ser
        675                 680                 685             
Asn Arg Gly Met Ala Phe Pro Cys Leu Glu Asp Ser Lys Glu Leu Glu
    690                 695                 700                 
His Val Gly Gln His Ala Leu Ala Arg Gln Ile Glu Glu Asn Arg Phe
705                 710                 715                 720 
Gln Cys Asp Ile Cys Lys Lys Thr Phe Lys Asn Ala Cys Ser Val Lys
                725                 730                 735     
Ile His His Lys Asn Met His Val Lys Glu Met His Thr Cys Thr Val
            740                 745                 750         
Glu Gly Cys Asn Ala Thr Phe Pro Ser Arg Arg Ser Arg Asp Arg His
        755                 760                 765             
Ser Ser Asn Leu Asn Leu His Gln Lys Ala Leu Ser Gln Glu Ala Leu
    770                 775                 780                 
Glu Ser Ser Glu Asp His Phe Arg Ala Ala Tyr Leu Leu Lys Asp Val
785                 790                 795                 800 
Ala Lys Glu Ala Tyr Gln Asp Val Ala Phe Thr Gln Gln Ala Ser Gln
                805                 810                 815     
Thr Ser Val Ile Phe Lys Gly Thr Ser Arg Met Gly Ser Leu Val Tyr
            820                 825                 830         
Pro Ile Thr Gln Val His Ser Ala Ser Leu Glu Ser Tyr Asn Ser Gly
        835                 840                 845             
Pro Leu Ser Glu Gly Thr Ile Leu Asp Leu Ser Thr Thr Ser Ser Met
    850                 855                 860                 
Lys Ser Glu Ser Ser Ser His Ser Ser Trp Asp Ser Asp Gly Val Ser
865                 870                 875                 880 
Glu Glu Gly Thr Val Leu Met Glu Asp Ser Asp Gly Asn Cys Glu Gly
                885                 890                 895     
Ser Ser Leu Val Pro Gly Glu Asp Glu Tyr Pro Ile Cys Val Leu Met
            900                 905                 910         
Glu Lys Ala Asp Gln Ser Leu Ala Ser Leu Pro Ser Gly Leu Pro Ile
        915                 920                 925             
Thr Cys His Leu Cys Gln Lys Thr Tyr Ser Asn Lys Gly Thr Phe Arg
    930                 935                 940                 
Ala His Tyr Lys Thr Val His Leu Arg Gln Leu His Lys Cys Lys Val
945                 950                 955                 960 
Pro Gly Cys Asn Thr Met Phe Ser Ser Val Arg Ser Arg Asn Arg His
                965                 970                 975     
Ser Gln Asn Pro Asn Leu His Lys Ser Leu Ala Ser Ser Pro Ser His
            980                 985                 990         
Leu Gln
        


<210> 6728
<211> 703
<212> PRT
<213> Homo sapiens

<400> 6728
Met Ala Glu Leu Met Leu Leu Ser Glu Ile Ala Asp Pro Thr Arg Phe
 1               5                  10                  15      
Phe Thr Asp Asn Leu Leu Ser Pro Glu Asp Trp Gly Leu Gln Asn Ser
            20                  25                  30          
Thr Leu Tyr Ser Gly Leu Asp Glu Val Ala Glu Glu Gln Thr Gln Leu
        35                  40                  45              
Phe Arg Cys Pro Glu Gln Asp Val Pro Phe Asp Gly Ser Ser Leu Asp
    50                  55                  60                  
Val Gly Met Asp Val Ser Pro Ser Glu Pro Pro Trp Glu Leu Leu Pro
65                  70                  75                  80  
Ile Phe Pro Asp Leu Gln Val Lys Ser Glu Pro Ser Ser Pro Cys Ser
                85                  90                  95      
Ser Ser Ser Leu Ser Ser Glu Ser Ser Arg Leu Ser Thr Glu Pro Ser
            100                 105                 110         
Ser Glu Ala Leu Gly Val Gly Glu Val Leu His Val Lys Thr Glu Ser
        115                 120                 125             
Leu Ala Pro Pro Leu Cys Leu Leu Gly Asp Asp Pro Thr Ser Ser Phe
    130                 135                 140                 
Glu Thr Val Gln Ile Asn Val Ile Pro Thr Ser Asp Asp Ser Ser Asp
145                 150                 155                 160 
Val Gln Thr Lys Ile Glu Pro Val Ser Pro Cys Ser Ser Val Asn Ser
                165                 170                 175     
Glu Ala Ser Leu Leu Ser Ala Asp Ser Ser Ser Gln Ala Phe Ile Gly
            180                 185                 190         
Glu Glu Val Leu Glu Val Lys Thr Glu Ser Leu Ser Pro Ser Gly Cys
        195                 200                 205             
Leu Leu Trp Asp Val Pro Ala Pro Ser Leu Gly Ala Val Gln Ile Ser
    210                 215                 220                 
Met Gly Pro Ser Leu Asp Gly Ser Ser Gly Lys Ala Leu Pro Thr Arg
225                 230                 235                 240 
Lys Pro Pro Leu Gln Pro Lys Pro Val Val Leu Thr Thr Val Pro Met
                245                 250                 255     
Pro Ser Arg Ala Val Pro Pro Ser Thr Thr Val Leu Leu Gln Ser Leu
            260                 265                 270         
Val Gln Pro Pro Pro Val Ser Pro Val Val Leu Ile Gln Gly Ala Ile
        275                 280                 285             
Arg Val Gln Pro Glu Gly Pro Ala Pro Ser Leu Pro Arg Pro Glu Arg
    290                 295                 300                 
Lys Ser Ile Val Pro Ala Pro Met Pro Gly Asn Ser Cys Pro Pro Glu
305                 310                 315                 320 
Val Asp Ala Lys Leu Leu Lys Arg Gln Gln Arg Met Ile Lys Asn Arg
                325                 330                 335     
Glu Ser Ala Cys Gln Ser Arg Arg Lys Lys Lys Glu Tyr Leu Gln Gly
            340                 345                 350         
Leu Glu Ala Arg Leu Gln Ala Val Leu Ala Asp Asn Gln Gln Leu Arg
        355                 360                 365             
Arg Glu Asn Ala Ala Leu Arg Arg Arg Leu Glu Ala Leu Leu Ala Glu
    370                 375                 380                 
Asn Ser Glu Leu Lys Leu Gly Ser Gly Asn Arg Lys Val Val Cys Ile
385                 390                 395                 400 
Met Val Phe Leu Leu Phe Ile Ala Phe Asn Phe Gly Pro Val Ser Ile
                405                 410                 415     
Ser Glu Pro Pro Ser Ala Pro Ile Ser Pro Arg Met Asn Lys Gly Glu
            420                 425                 430         
Pro Gln Pro Arg Arg His Leu Leu Gly Phe Ser Glu Gln Glu Pro Val
        435                 440                 445             
Gln Gly Val Glu Pro Leu Gln Gly Ser Ser Gln Gly Pro Lys Glu Pro
    450                 455                 460                 
Gln Pro Ser Pro Thr Asp Gln Pro Ser Phe Ser Asn Leu Thr Ala Phe
465                 470                 475                 480 
Pro Gly Gly Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu Phe
                485                 490                 495     
Leu Ser Ser Asp Cys Arg His Phe Asn Arg Thr Glu Ser Leu Arg Leu
            500                 505                 510         
Ala Asp Glu Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg Arg
        515                 520                 525             
Lys Ile Pro Gln Arg Ala Gln Glu Arg Gln Lys Ser Gln Pro Arg Lys
    530                 535                 540                 
Lys Ser Pro Pro Val Lys Ala Val Pro Ile Gln Pro Pro Gly Pro Pro
545                 550                 555                 560 
Glu Arg Asp Ser Val Gly Gln Leu Gln Leu Tyr Arg His Pro Asp Arg
                565                 570                 575     
Ser Gln Pro Ala Phe Leu Asp Ala Ile Asp Arg Arg Glu Asp Thr Phe
            580                 585                 590         
Tyr Val Val Ser Phe Arg Arg Asp His Leu Leu Leu Pro Ala Ile Ser
        595                 600                 605             
His Asn Lys Thr Ser Arg Pro Lys Met Ser Leu Val Met Pro Ala Met
    610                 615                 620                 
Ala Pro Asn Glu Thr Leu Ser Gly Arg Gly Ala Pro Gly Asp Tyr Glu
625                 630                 635                 640 
Glu Met Met Gln Ile Glu Cys Glu Val Met Asp Thr Arg Val Ile His
                645                 650                 655     
Ile Lys Thr Ser Thr Val Pro Pro Ser Leu Arg Lys Gln Pro Ser Pro
            660                 665                 670         
Thr Pro Gly Asn Ala Thr Gly Gly Pro Leu Pro Val Ser Ala Ala Ser
        675                 680                 685             
Gln Ala His Gln Ala Ser His Gln Pro Leu Tyr Leu Asn His Pro
    690                 695                 700             


<210> 6729
<211> 700
<212> PRT
<213> Homo sapiens

<400> 6729
Met Ala Glu Leu Met Leu Leu Ser Glu Ile Ala Asp Pro Thr Arg Phe
 1               5                  10                  15      
Phe Thr Asp Asn Leu Leu Ser Pro Glu Asp Trp Asp Ser Thr Leu Tyr
            20                  25                  30          
Ser Gly Leu Asp Glu Val Ala Glu Glu Gln Thr Gln Leu Phe Arg Cys
        35                  40                  45              
Pro Glu Gln Asp Val Pro Phe Asp Gly Ser Ser Leu Asp Val Gly Met
    50                  55                  60                  
Asp Val Ser Pro Ser Glu Pro Pro Trp Glu Leu Leu Pro Ile Phe Pro
65                  70                  75                  80  
Asp Leu Gln Val Lys Ser Glu Pro Ser Ser Pro Cys Ser Ser Ser Ser
                85                  90                  95      
Leu Ser Ser Glu Ser Ser Arg Leu Ser Thr Glu Pro Ser Ser Glu Ala
            100                 105                 110         
Leu Gly Val Gly Glu Val Leu His Val Lys Thr Glu Ser Leu Ala Pro
        115                 120                 125             
Pro Leu Cys Leu Leu Gly Asp Asp Pro Thr Ser Ser Phe Glu Thr Val
    130                 135                 140                 
Gln Ile Asn Val Ile Pro Thr Ser Asp Asp Ser Ser Asp Val Gln Thr
145                 150                 155                 160 
Lys Ile Glu Pro Val Ser Pro Cys Ser Ser Val Asn Ser Glu Ala Ser
                165                 170                 175     
Leu Leu Ser Ala Asp Ser Ser Ser Gln Ala Phe Ile Gly Glu Glu Val
            180                 185                 190         
Leu Glu Val Lys Thr Glu Ser Leu Ser Pro Ser Gly Cys Leu Leu Trp
        195                 200                 205             
Asp Val Pro Ala Pro Ser Leu Gly Ala Val Gln Ile Ser Met Gly Pro
    210                 215                 220                 
Ser Leu Asp Gly Ser Ser Gly Lys Ala Leu Pro Thr Arg Lys Pro Pro
225                 230                 235                 240 
Leu Gln Pro Lys Pro Val Val Leu Thr Thr Val Pro Met Pro Ser Arg
                245                 250                 255     
Ala Val Pro Pro Ser Thr Thr Val Leu Leu Gln Ser Leu Val Gln Pro
            260                 265                 270         
Pro Pro Val Ser Pro Val Val Leu Ile Gln Gly Ala Ile Arg Val Gln
        275                 280                 285             
Pro Glu Gly Pro Ala Pro Ser Leu Pro Arg Pro Glu Arg Lys Ser Ile
    290                 295                 300                 
Val Pro Ala Pro Met Pro Gly Asn Ser Cys Pro Pro Glu Val Asp Ala
305                 310                 315                 320 
Lys Leu Leu Lys Arg Gln Gln Arg Met Ile Lys Asn Arg Glu Ser Ala
                325                 330                 335     
Cys Gln Ser Arg Arg Lys Lys Lys Glu Tyr Leu Gln Gly Leu Glu Ala
            340                 345                 350         
Arg Leu Gln Ala Val Leu Ala Asp Asn Gln Gln Leu Arg Arg Glu Asn
        355                 360                 365             
Ala Ala Leu Arg Arg Arg Leu Glu Ala Leu Leu Ala Glu Asn Ser Glu
    370                 375                 380                 
Leu Lys Leu Gly Ser Gly Asn Arg Lys Val Val Cys Ile Met Val Phe
385                 390                 395                 400 
Leu Leu Phe Ile Ala Phe Asn Phe Gly Pro Val Ser Ile Ser Glu Pro
                405                 410                 415     
Pro Ser Ala Pro Ile Ser Pro Arg Met Asn Lys Gly Glu Pro Gln Pro
            420                 425                 430         
Arg Arg His Leu Leu Gly Phe Ser Glu Gln Glu Pro Val Gln Gly Val
        435                 440                 445             
Glu Pro Leu Gln Gly Ser Ser Gln Gly Pro Lys Glu Pro Gln Pro Ser
    450                 455                 460                 
Pro Thr Asp Gln Pro Ser Phe Ser Asn Leu Thr Ala Phe Pro Gly Gly
465                 470                 475                 480 
Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu Phe Leu Ser Ser
                485                 490                 495     
Asp Cys Arg His Phe Asn Arg Thr Glu Ser Leu Arg Leu Ala Asp Glu
            500                 505                 510         
Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg Arg Lys Ile Pro
        515                 520                 525             
Gln Arg Ala Gln Glu Arg Gln Lys Ser Gln Pro Arg Lys Lys Ser Pro
    530                 535                 540                 
Pro Val Lys Ala Val Pro Ile Gln Pro Pro Gly Pro Pro Glu Arg Asp
545                 550                 555                 560 
Ser Val Gly Gln Leu Gln Leu Tyr Arg His Pro Asp Arg Ser Gln Pro
                565                 570                 575     
Ala Phe Leu Asp Ala Ile Asp Arg Arg Glu Asp Thr Phe Tyr Val Val
            580                 585                 590         
Ser Phe Arg Arg Asp His Leu Leu Leu Pro Ala Ile Ser His Asn Lys
        595                 600                 605             
Thr Ser Arg Pro Lys Met Ser Leu Val Met Pro Ala Met Ala Pro Asn
    610                 615                 620                 
Glu Thr Leu Ser Gly Arg Gly Ala Pro Gly Asp Tyr Glu Glu Met Met
625                 630                 635                 640 
Gln Ile Glu Cys Glu Val Met Asp Thr Arg Val Ile His Ile Lys Thr
                645                 650                 655     
Ser Thr Val Pro Pro Ser Leu Arg Lys Gln Pro Ser Pro Thr Pro Gly
            660                 665                 670         
Asn Ala Thr Gly Gly Pro Leu Pro Val Ser Ala Ala Ser Gln Ala His
        675                 680                 685             
Gln Ala Ser His Gln Pro Leu Tyr Leu Asn His Pro
    690                 695                 700 


<210> 6730
<211> 410
<212> PRT
<213> Homo sapiens

<400> 6730
Ile Phe Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser Asp Ile
 1               5                  10                  15      
Asp Leu Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp Thr Leu
            20                  25                  30          
Glu Glu Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser Val Lys
        35                  40                  45              
Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp Ser Phe
    50                  55                  60                  
Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly Val Arg
65                  70                  75                  80  
Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val Leu Pro
                85                  90                  95      
Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp Leu Asn
            100                 105                 110         
Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu Met Ala
        115                 120                 125             
Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile Pro Asn
    130                 135                 140                 
Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr Gly Arg
145                 150                 155                 160 
His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly Gly Ser
                165                 170                 175     
Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly Tyr Arg
            180                 185                 190         
Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn Asp Val
        195                 200                 205             
Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe Asp Tyr
    210                 215                 220                 
Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys Tyr Tyr
225                 230                 235                 240 
Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg Val Thr
                245                 250                 255     
Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp Gly Leu
            260                 265                 270         
Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Pro Val Ser Ser Ser Ser
        275                 280                 285             
Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro Cys
    290                 295                 300                 
Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg Val
305                 310                 315                 320 
Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys Met
                325                 330                 335     
Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys Ser Gln
            340                 345                 350         
His Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe Gln Gly
        355                 360                 365             
Thr Thr Gln Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln His Gln
    370                 375                 380                 
Gly Lys Ser Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys His Lys
385                 390                 395                 400 
Arg Asp Ala Pro Leu Ser Asp Leu Cys Arg
                405                 410 


<210> 6731
<211> 379
<212> PRT
<213> Homo sapiens

<400> 6731
His Glu Val Lys Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu
 1               5                  10                  15      
Thr Asp Ser Phe Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln
            20                  25                  30          
Asn Gly Val Arg Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr
        35                  40                  45              
Pro Val Leu Pro Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln
    50                  55                  60                  
Arg Asp Leu Asn Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu
65                  70                  75                  80  
Phe Leu Met Ala Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala
                85                  90                  95      
Cys Ile Pro Asn Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu
            100                 105                 110         
Leu Tyr Gly Arg His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys
        115                 120                 125             
Asp Gly Gly Ser Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu
    130                 135                 140                 
Asp Gly Tyr Arg Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro
145                 150                 155                 160 
Gly Asn Asp Val Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln
                165                 170                 175     
Ala Phe Asp Tyr Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile
            180                 185                 190         
Ala Lys Tyr Tyr Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile
        195                 200                 205             
Ile Arg Val Thr Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys
    210                 215                 220                 
Gln Trp Gly Leu Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Asn Gly
225                 230                 235                 240 
Val Thr Leu Ile Val Asp Thr Gln Gln Leu Asp Lys Cys Asn Asn Asn
                245                 250                 255     
Leu Ser Glu Glu Asn Glu Ala Leu Gly Lys Cys Arg Ser Lys Thr Ser
            260                 265                 270         
Glu Ser Leu Ser Lys His Ser Ser Asn Ser Ser Ser Gly Pro Val Ser
        275                 280                 285             
Ser Ser Ser Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala
    290                 295                 300                 
Thr Pro Cys Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly
305                 310                 315                 320 
Asn Arg Val Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val
                325                 330                 335     
Gly Lys Met Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn
            340                 345                 350         
Lys Ser Gln His Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly
        355                 360                 365             
Phe Gln Gly Thr Thr Gln Thr Ser His Gly Ser
    370                 375                 


<210> 6732
<211> 503
<212> PRT
<213> Homo sapiens

<400> 6732
Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His
        115                 120                 125             
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys
                325                 330                 335     
Asn Ser Ala Ala Ala Thr Ser Pro Lys Gly Thr Leu Pro Pro Ala Ala
            340                 345                 350         
Leu Glu Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala
        355                 360                 365             
Lys Ala Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu
    370                 375                 380                 
Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro
385                 390                 395                 400 
Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly
                405                 410                 415     
Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser
            420                 425                 430         
Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile Gly
        435                 440                 445             
Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp
    450                 455                 460                 
Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val Trp
465                 470                 475                 480 
His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly
                485                 490                 495     
Ala Pro Val Ala Pro Leu Gln
            500             


<210> 6733
<211> 499
<212> PRT
<213> Homo sapiens

<400> 6733
Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met
            20                  25                  30          
Lys Ile Pro Thr Gly Gln Gly Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His
        115                 120                 125             
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr
                325                 330                 335     
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys
            340                 345                 350         
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala
        355                 360                 365             
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala
    370                 375                 380                 
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu
385                 390                 395                 400 
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn
                405                 410                 415     
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile
            420                 425                 430         
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln
        435                 440                 445             
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn
    450                 455                 460                 
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro
465                 470                 475                 480 
Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp
                485                 490                 495     
Gln Asn Ile
            


<210> 6734
<211> 478
<212> PRT
<213> Homo sapiens

<400> 6734
Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met
            20                  25                  30          
Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His
        115                 120                 125             
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr
                325                 330                 335     
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys
            340                 345                 350         
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala
        355                 360                 365             
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala
    370                 375                 380                 
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu
385                 390                 395                 400 
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn
                405                 410                 415     
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile
            420                 425                 430         
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln
        435                 440                 445             
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn
    450                 455                 460                 
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Asn
465                 470                 475             


<210> 6735
<211> 518
<212> PRT
<213> Homo sapiens

<400> 6735
Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His
        115                 120                 125             
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys
                325                 330                 335     
Asn Ser Ala Ala Ala Thr Ser Pro Lys Gly Thr Leu Pro Pro Ala Ala
            340                 345                 350         
Leu Glu Pro Gln Thr Thr Val Ile His Asn Pro Val Asp Gly Ile Lys
        355                 360                 365             
Glu Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala Lys
    370                 375                 380                 
Ala Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu Ala
385                 390                 395                 400 
Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly
                405                 410                 415     
Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met
            420                 425                 430         
Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys
        435                 440                 445             
Pro Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile Gly Glu
    450                 455                 460                 
Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp Gly
465                 470                 475                 480 
Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val Trp His
                485                 490                 495     
Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly Ala
            500                 505                 510         
Pro Val Ala Pro Leu Gln
        515             


<210> 6736
<211> 478
<212> PRT
<213> Homo sapiens

<400> 6736
Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met
            20                  25                  30          
Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His
        115                 120                 125             
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr
                325                 330                 335     
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys
            340                 345                 350         
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala
        355                 360                 365             
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala
    370                 375                 380                 
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu
385                 390                 395                 400 
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn
                405                 410                 415     
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile
            420                 425                 430         
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln
        435                 440                 445             
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn
    450                 455                 460                 
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys
465                 470                 475             


<210> 6737
<211> 479
<212> PRT
<213> Homo sapiens

<400> 6737
Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His
        115                 120                 125             
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Asn Lys Lys Ala Asp Gly Val Lys Glu Ser Ser Asp Ser Ala Asn
                325                 330                 335     
Thr Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile
            340                 345                 350         
Lys Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu
        355                 360                 365             
Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu
    370                 375                 380                 
Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe
385                 390                 395                 400 
Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu
                405                 410                 415     
Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr
            420                 425                 430         
Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser
        435                 440                 445             
Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln
    450                 455                 460                 
Asn Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln
465                 470                 475                 


<210> 6738
<211> 574
<212> PRT
<213> Homo sapiens

<400> 6738
Lys Glu Ala Ala Ser Gly Lys Ser Asp Arg Arg Thr Pro Glu Ser Ser
 1               5                  10                  15      
Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp Leu Phe Leu
            20                  25                  30          
Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro Arg Thr Lys
        35                  40                  45              
Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu Glu Met Gln
    50                  55                  60                  
Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala Gly Asn Met
65                  70                  75                  80  
Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg Lys Ser Ser
                85                  90                  95      
Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr Leu Gly Gln
            100                 105                 110         
Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala Glu Cys Leu
        115                 120                 125             
Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Asp Glu Asn Met Val Ser
    130                 135                 140                 
Phe Ile Lys Gly Gly Ile Lys Val Arg Asn Ser Tyr Gln Thr Tyr Lys
145                 150                 155                 160 
Glu Leu Asp Ser Leu Val Gln Ser Ser Gln Tyr Cys Lys Gly Glu Asn
                165                 170                 175     
His Pro His Phe Glu Gly Gly Val Lys Leu Gly Val Gly Ala Phe Asn
            180                 185                 190         
Leu Thr Leu Ser Met Leu Pro Thr Arg Ile Leu Arg Leu Leu Glu Phe
        195                 200                 205             
Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly Leu Leu Gln Leu Glu Glu
    210                 215                 220                 
Gly Ala Ser Gly His Ser Phe Arg Ser Val Leu Cys Val Met Leu Leu
225                 230                 235                 240 
Leu Cys Tyr His Thr Phe Leu Thr Phe Val Leu Gly Thr Gly Asn Val
                245                 250                 255     
Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys Pro Tyr Leu Asn Arg Tyr
            260                 265                 270         
Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala Gly Arg Ile Glu Val Ile
        275                 280                 285             
Lys Gly Asn Ile Asp Ala Ala Ile Arg Arg Phe Glu Glu Cys Cys Glu
    290                 295                 300                 
Ala Gln Gln His Trp Lys Gln Phe His His Met Cys Tyr Trp Glu Leu
305                 310                 315                 320 
Met Trp Cys Phe Thr Tyr Lys Gly Gln Trp Lys Met Ser Tyr Phe Tyr
                325                 330                 335     
Ala Asp Leu Leu Ser Lys Glu Asn Cys Trp Ser Lys Ala Thr Tyr Ile
            340                 345                 350         
Tyr Met Lys Ala Ala Tyr Leu Ser Met Phe Gly Lys Glu Asp His Lys
        355                 360                 365             
Pro Phe Gly Asp Asp Glu Val Glu Leu Phe Arg Ala Val Pro Gly Leu
    370                 375                 380                 
Lys Leu Lys Ile Ala Gly Lys Ser Leu Pro Thr Glu Lys Phe Ala Ile
385                 390                 395                 400 
Arg Lys Ser Arg Arg Tyr Phe Ser Ser Asn Pro Ile Ser Leu Pro Val
                405                 410                 415     
Pro Ala Leu Glu Met Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly
            420                 425                 430         
Lys Gln Pro Lys Leu Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala
        435                 440                 445             
Glu Glu Met Leu Glu Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp
    450                 455                 460                 
Glu Cys Leu Val Lys Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly
465                 470                 475                 480 
Arg Val Gln Glu Ala Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu
                485                 490                 495     
Lys Lys Ile Lys Tyr Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu
            500                 505                 510         
Leu Ala Leu Leu Leu Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys
        515                 520                 525             
Leu Leu Glu Ser Ala Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser
    530                 535                 540                 
Arg Thr His Phe Arg Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser
545                 550                 555                 560 
Leu Glu Asn Ser Ser Arg Ser Met Val Ser Ser Val Ser Leu
                565                 570                 


<210> 6739
<211> 453
<212> PRT
<213> Homo sapiens

<400> 6739
Val Glu Thr Pro Pro Gln Gly Ser Val His Ser Gly His Leu Gly Ser
 1               5                  10                  15      
Val Val Gly Asp Pro His Thr Gly Thr Gly Asn Ala Gly Glu Arg Gly
            20                  25                  30          
Pro Arg Gly Lys Gly Ala Arg Val Leu Ala Leu Asp Ser Gly Gly Met
        35                  40                  45              
Asp Ser Ser Pro Ser Leu Pro Leu Ile Arg Thr Pro Glu Ser Ser Leu
    50                  55                  60                  
His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp Leu Phe Leu Thr
65                  70                  75                  80  
Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro Arg Thr Lys Glu
                85                  90                  95      
Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu Glu Met Gln Ala
            100                 105                 110         
Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala Gly Asn Met Met
        115                 120                 125             
Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg Lys Ser Ser Val
    130                 135                 140                 
Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr Leu Gly Gln Phe
145                 150                 155                 160 
Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala Glu Cys Leu Leu
                165                 170                 175     
Gln Arg Ala Ala Leu Thr Phe Leu Gln Gly Ser Ser His Gly Gly Ala
            180                 185                 190         
Val Arg Pro Arg Ala Leu His Asp Pro Ser His Ala Cys Ser Cys Pro
        195                 200                 205             
Pro Gly Pro Gly Arg Gln His Leu Phe Leu Leu Gln Asp Glu Asn Met
    210                 215                 220                 
Val Ser Phe Ile Lys Gly Gly Ile Lys Val Arg Asn Ser Tyr Gln Thr
225                 230                 235                 240 
Tyr Lys Glu Leu Asp Ser Leu Val Gln Ser Ser Gln Tyr Cys Lys Gly
                245                 250                 255     
Glu Asn His Pro His Phe Glu Gly Gly Val Lys Leu Gly Val Gly Ala
            260                 265                 270         
Phe Asn Leu Thr Leu Ser Met Leu Pro Thr Arg Ile Leu Arg Leu Leu
        275                 280                 285             
Glu Phe Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly Leu Leu Gln Leu
    290                 295                 300                 
Glu Glu Gly Ala Ser Gly His Ser Phe Arg Ser Val Leu Cys Val Met
305                 310                 315                 320 
Leu Leu Leu Cys Tyr His Thr Phe Leu Thr Phe Val Leu Gly Thr Gly
                325                 330                 335     
Asn Val Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys Pro Tyr Leu Asn
            340                 345                 350         
Arg Tyr Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala Gly Arg Ile Glu
        355                 360                 365             
Val Ile Lys Gly Asn Ile Asp Ala Val Ser Asp Gly Gly Pro Gly Arg
    370                 375                 380                 
Gly Trp Gly Ser Leu Gly Val Ser Gln Thr Ser Arg Lys Ser Gly Thr
385                 390                 395                 400 
Cys Asp Ile Leu Arg Asp Arg Ile Asp Trp Gly Arg Gly Gly Gly Pro
                405                 410                 415     
Arg Glu Asn Gln Pro Glu Ser Arg Gly Arg Arg Gly Pro Ser Gly Arg
            420                 425                 430         
Ala Ala Trp Glu Asp Lys Gly Gly Gly Gly Ile Cys Gly Ala Trp Asp
        435                 440                 445             
Phe Asp Trp Glu Ile
    450             


<210> 6740
<211> 214
<212> PRT
<213> Homo sapiens

<400> 6740
Val Ser Thr Glu His Phe Thr Gln Gln Tyr Ser Ser Cys Ser Thr Ile
 1               5                  10                  15      
Phe Leu Asp Asp Ser Ile Ala Ser Gln Pro His Leu Thr Met Thr Leu
            20                  25                  30          
Lys Ser Val Thr Leu Ala Leu Tyr Tyr His Ile Lys Gln Ser Thr Ser
        35                  40                  45              
Gly Phe Phe Leu Gln Trp Ile Leu Thr Leu His Pro Phe Phe Phe Gln
    50                  55                  60                  
Arg Lys Glu Val Leu Glu Glu Tyr Phe Lys Tyr Asp Pro Glu His Lys
65                  70                  75                  80  
Leu Ile Phe Arg Phe Val Arg Thr Leu Phe Lys Ala Met Arg Leu Thr
                85                  90                  95      
Ala Glu Phe Ala Ile Val Ser Leu Ile Tyr Ile Glu Arg Leu Val Ser
            100                 105                 110         
Tyr Ala Asp Ile Asp Ile Cys Pro Thr Asn Trp Lys Arg Ile Val Leu
        115                 120                 125             
Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Ser Asp Met Ala Val Trp
    130                 135                 140                 
Asn Glu Asp Tyr Cys Lys Leu Phe Lys Asn Ile Thr Val Glu Glu Met
145                 150                 155                 160 
Asn Glu Leu Glu Arg Gln Phe Leu Lys Leu Ile Asn Tyr Asn Asn Ser
                165                 170                 175     
Ile Thr Asn Ser Val Tyr Ser Arg Phe Tyr Phe Asp Leu Arg Thr Leu
            180                 185                 190         
Ala His Asn Asn Gly Leu Tyr Ser Pro Val Tyr Leu Leu Asp Arg Glu
        195                 200                 205             
Arg Ala Trp Lys Leu Glu
    210                 


<210> 6741
<211> 430
<212> PRT
<213> Homo sapiens

<400> 6741
Met His Thr Gln Ser Pro Glu Arg Phe Thr Ser Ala Ser Glu Leu Gly
 1               5                  10                  15      
Thr Asn Asn Val Ser Ala Phe Gln Ser Asp Gln Ala Ala Ser Glu Ile
            20                  25                  30          
Glu Val Thr Ser Ser Val Leu His Ala Thr Ser Leu Ser Val Ser Thr
        35                  40                  45              
Ala Arg Gln Pro Ala Pro Asn Ala Asn Ile Ser Gly His Ser Leu Gln
    50                  55                  60                  
Ala Pro Asn Asp Ser Gly Thr Leu Thr Val Thr Lys Ser Val Ser Pro
65                  70                  75                  80  
Arg Asn Ser Pro Thr Thr His Gly Trp Pro Asp Pro Arg Ala Ser Pro
                85                  90                  95      
Gly Leu His Gln His Gln Gly Leu Val Cys His Cys Glu Ser Glu Ile
            100                 105                 110         
Tyr Glu Ala Ala Ala Gly Asp Leu Ile Ala Gly Val Pro Val Ala Ala
        115                 120                 125             
Ala Val Glu Pro Gly Glu Val Thr Phe Val Ala Gly Glu Gly Leu His
    130                 135                 140                 
Met His His Ile Cys Glu Arg Glu Met Pro Glu Asp Ile Pro Leu Glu
145                 150                 155                 160 
Pro Asn Pro Ser Asp His Pro Lys Ala Ser Thr Ile Phe Leu Arg Lys
                165                 170                 175     
Ser Gln Thr Asp Val Pro Ser Arg Ala Met Gly Phe Ser His Ile Glu
            180                 185                 190         
Ser Ile Glu Glu Val Ser Thr Glu His Phe Thr Gln Gln Tyr Ser Ser
        195                 200                 205             
Cys Ser Thr Ile Phe Leu Asp Asp Ser Ile Ala Ser Gln Pro His Leu
    210                 215                 220                 
Thr Met Thr Leu Lys Ser Ser Leu Leu Leu Lys Cys Asp Leu Gly Thr
225                 230                 235                 240 
Ile Leu Ser Tyr Gln Ala Lys Arg Lys Glu Val Leu Glu Glu Tyr Phe
                245                 250                 255     
Lys Tyr Asp Pro Glu His Lys Leu Ile Phe Arg Phe Val Arg Thr Leu
            260                 265                 270         
Phe Lys Ala Met Arg Leu Thr Ala Glu Phe Ala Ile Ile Tyr Ile Glu
        275                 280                 285             
Arg Leu Val Ser Tyr Ala Asp Ile Asp Ile Cys Pro Thr Asn Trp Lys
    290                 295                 300                 
Arg Ile Val Leu Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Ser Asp
305                 310                 315                 320 
Met Ala Val Trp Asn Glu Asp Tyr Cys Lys Leu Phe Lys Asn Ile Thr
                325                 330                 335     
Val Glu Glu Met Asn Glu Leu Glu Arg Gln Phe Leu Lys Leu Ile Asn
            340                 345                 350         
Tyr Asn Asn Ser Ile Thr Asn Ser Val Tyr Ser Arg Phe Tyr Phe Asp
        355                 360                 365             
Leu Arg Thr Leu Ala His Asn Asn Gly Leu Tyr Ser Pro Val Tyr Leu
    370                 375                 380                 
Leu Asp Arg Glu Arg Ala Trp Lys Leu Glu Ala Phe Ser Arg Met Glu
385                 390                 395                 400 
Gln Asp Lys Val Phe Tyr Ser Ala Ala Lys Asn Gly Ser Leu Ser Ala
                405                 410                 415     
Asp Asp Leu Ile His Leu Gln Arg Ala Lys Ala Ile Leu Phe
            420                 425                 430 


<210> 6742
<211> 213
<212> PRT
<213> Homo sapiens

<400> 6742
Ile Tyr Glu His Phe Thr Gln Gln Tyr Ser Ser Cys Ser Thr Ile Phe
 1               5                  10                  15      
Leu Asp Asp Ser Ile Ala Ser Gln Pro His Leu Thr Met Thr Leu Lys
            20                  25                  30          
Ser Val Thr Leu Ala Leu Tyr Tyr His Ile Lys Gln Ser Thr Ser Gly
        35                  40                  45              
Phe Phe Leu Gln Trp Ile Leu Thr Leu His Pro Phe Phe Phe Gln Arg
    50                  55                  60                  
Lys Glu Val Leu Glu Glu Tyr Phe Lys Tyr Asp Pro Glu His Lys Leu
65                  70                  75                  80  
Ile Phe Arg Phe Val Arg Thr Leu Phe Lys Ala Met Arg Leu Thr Ala
                85                  90                  95      
Glu Phe Ala Ile Val Ser Leu Ile Tyr Ile Glu Arg Leu Val Ser Tyr
            100                 105                 110         
Ala Asp Ile Asp Ile Cys Pro Thr Asn Trp Lys Arg Ile Val Leu Gly
        115                 120                 125             
Ala Ile Leu Leu Ala Ser Lys Val Trp Ser Asp Met Ala Val Trp Asn
    130                 135                 140                 
Glu Asp Tyr Cys Lys Leu Phe Lys Asn Ile Thr Val Glu Glu Met Asn
145                 150                 155                 160 
Glu Leu Glu Arg Gln Phe Leu Lys Leu Ile Asn Tyr Asn Asn Ser Ile
                165                 170                 175     
Thr Asn Ser Val Tyr Ser Arg Phe Tyr Phe Asp Leu Arg Thr Leu Ala
            180                 185                 190         
His Asn Asn Gly Leu Tyr Ser Pro Val Tyr Leu Leu Asp Arg Glu Arg
        195                 200                 205             
Ala Trp Lys Leu Glu
    210             


<210> 6743
<211> 367
<212> PRT
<213> Homo sapiens

<400> 6743
Met Ala Ala Leu Arg Trp Val Gln Glu Asn Ile Ala Ala Phe Gly Gly
 1               5                  10                  15      
Asp Pro Gly Asn Val Thr Leu Phe Gly Gln Ser Ala Gly Ala Met Ser
            20                  25                  30          
Ile Ser Gly Leu Met Met Ser Pro Leu Ala Ser Gly Leu Phe His Arg
        35                  40                  45              
Ala Ile Ser Gln Ser Gly Thr Ala Leu Phe Arg Pro Phe Ile Thr Ser
    50                  55                  60                  
Asn Pro Leu Lys Val Ala Lys Lys Val Ala His Leu Ala Gly Cys Asn
65                  70                  75                  80  
His Asn Ser Thr Gln Ile Leu Val Asn Cys Leu Arg Ala Leu Ser Gly
                85                  90                  95      
Thr Lys Val Met Arg Val Ser Asn Lys Met Arg Phe Leu Gln Leu Asn
            100                 105                 110         
Phe Gln Arg Asp Pro Glu Glu Ile Ile Trp Ser Met Ser Pro Val Val
        115                 120                 125             
Asp Gly Val Val Ile Pro Asp Asp Pro Leu Val Leu Leu Thr Gln Gly
    130                 135                 140                 
Lys Val Ser Ser Val Pro Tyr Leu Leu Gly Val Asn Asn Leu Glu Phe
145                 150                 155                 160 
Asn Trp Leu Leu Pro Tyr Ile Met Lys Phe Pro Leu Asn Arg Gln Ala
                165                 170                 175     
Met Arg Lys Glu Thr Ile Thr Lys Met Leu Trp Ser Thr Arg Thr Leu
            180                 185                 190         
Leu Asn Ile Thr Lys Glu Gln Val Pro Leu Val Val Glu Glu Tyr Leu
        195                 200                 205             
Asp Asn Val Asn Glu His Asp Trp Lys Met Leu Arg Asn Arg Met Met
    210                 215                 220                 
Asp Ile Val Gln Asp Ala Thr Phe Val Tyr Ala Thr Leu Gln Thr Ala
225                 230                 235                 240 
His Tyr His Arg Asp Ala Gly Leu Pro Val Tyr Leu Tyr Glu Phe Glu
                245                 250                 255     
His His Ala Arg Gly Ile Ile Val Lys Pro Arg Thr Asp Gly Ala Asp
            260                 265                 270         
His Gly Asp Glu Met Tyr Phe Leu Phe Gly Gly Pro Phe Ala Thr Gly
        275                 280                 285             
Leu Ser Met Gly Lys Glu Lys Ala Leu Ser Leu Gln Met Met Lys Tyr
    290                 295                 300                 
Trp Ala Asn Phe Ala Arg Thr Gly Asn Pro Asn Asp Gly Asn Leu Pro
305                 310                 315                 320 
Cys Trp Pro Arg Tyr Asn Lys Asp Glu Lys Tyr Leu Gln Leu Asp Phe
                325                 330                 335     
Thr Thr Arg Val Gly Met Lys Leu Lys Glu Lys Lys Met Ala Phe Trp
            340                 345                 350         
Met Ser Leu Tyr Gln Ser Gln Arg Pro Glu Lys Gln Arg Gln Phe
        355                 360                 365         


<210> 6744
<211> 1557
<212> PRT
<213> Homo sapiens

<400> 6744
Met Gln Asn Ile Pro Phe Pro Ser Pro Gln Arg Pro Arg Ile Leu Val
 1               5                  10                  15      
Gln Leu Ser Val His Asp Ala Leu Ile Leu Ser Gln Pro Val Ser Thr
            20                  25                  30          
Pro Leu Pro Leu Ser Gly Ala Asn Phe Ser Thr Leu Leu Met Asn Leu
        35                  40                  45              
Gly Pro Glu Asn Cys Ala Thr Leu Leu Leu Phe Val Leu Leu Glu Ser
    50                  55                  60                  
Lys Ile Leu Leu His Ser Leu Arg Pro Ala Val Leu Thr Gly Val Ala
65                  70                  75                  80  
Glu Ala Val Val Ala Met Ile Phe Pro Phe Gln Trp Gln Cys Pro Tyr
                85                  90                  95      
Ile Pro Leu Cys Pro Leu Ser Leu Ala Ala Val Leu Ser Ala Pro Leu
            100                 105                 110         
Pro Phe Ile Val Gly Val Asp Ser Arg Tyr Phe Asp Leu His Asp Pro
        115                 120                 125             
Pro Gln Asp Val Val Cys Ile Asp Leu Asp Thr Asn Met Leu Tyr Val
    130                 135                 140                 
Ser Asp Glu Lys Lys Asn Met Asn Trp Lys Gln Leu Pro Lys Lys Pro
145                 150                 155                 160 
Cys Lys Asn Leu Leu Ser Thr Leu Lys Lys Leu Tyr Pro Gln Leu Ser
                165                 170                 175     
Ser Val His Gln Lys Thr Gln Glu Gly Ser Ala Ile Asp Met Thr Pro
            180                 185                 190         
Ile Glu Ala Asp Phe Ser Trp Gln Lys Lys Met Thr Gln Leu Glu Met
        195                 200                 205             
Glu Ile Gln Glu Ala Phe Leu Arg Phe Met Ala Ser Ile Leu Lys Gly
    210                 215                 220                 
Tyr Arg Thr Tyr Leu Arg Pro Ile Thr Glu Ala Pro Ser Asn Lys Ala
225                 230                 235                 240 
Thr Ala Ala Asp Ser Leu Phe Asp Arg Gln Gly Phe Leu Lys Ser Arg
                245                 250                 255     
Asp Arg Ala Tyr Ala Lys Phe Tyr Thr Leu Leu Ser Lys Thr Gln Ile
            260                 265                 270         
Phe Ile Arg Phe Ile Glu Glu Cys Ser Phe Val Ser Asp Lys Asp Thr
        275                 280                 285             
Gly Leu Ala Phe Phe Asp Asp Cys Ile Glu Lys Leu Phe Pro Asp Lys
    290                 295                 300                 
Gly Thr Glu Lys Thr Asp Lys Val Asp Phe Asp Ser Ala Glu Asp Thr
305                 310                 315                 320 
Arg Leu Ile Glu Leu Asp Asp Ser Gln Lys Gly Glu His Thr Val Phe
                325                 330                 335     
Ile Met Pro Pro Glu Pro Pro Pro Asp Asp Gly Lys Asp Leu Ser Pro
            340                 345                 350         
Lys Tyr Ser Tyr Lys Tyr Phe Pro Arg Leu Asp Leu Lys Leu Phe Asp
        355                 360                 365             
Arg Pro Gln Glu Leu Lys Leu Cys Phe Ser Arg His Pro Thr Gly Asn
    370                 375                 380                 
Ser Ile Thr Lys Ser Pro Pro Leu Met Ala Lys Arg Thr Lys Gln Glu
385                 390                 395                 400 
Ile Lys Thr Ala His Lys Leu Ala Lys Arg Cys Tyr Thr Asn Pro Pro
                405                 410                 415     
Gln Trp Ala Lys Cys Leu Phe Ser His Cys Tyr Ser Leu Trp Phe Ile
            420                 425                 430         
Cys Leu Pro Ala Tyr Val Arg Val Ser His Pro Lys Val Arg Ala Leu
        435                 440                 445             
Gln Gln Ala Tyr Asp Val Leu Ile Lys Met Arg Lys Thr Asp Val Asp
    450                 455                 460                 
Pro Leu Asp Glu Val Cys Tyr Arg Val Val Met Gln Leu Cys Gly Leu
465                 470                 475                 480 
Trp Gly His Pro Val Leu Ala Val Arg Val Leu Phe Glu Met Lys Thr
                485                 490                 495     
Ala Arg Ile Lys Pro Asn Ala Ile Thr Tyr Gly Tyr Tyr Asn Lys Val
            500                 505                 510         
Val Leu Glu Ser Pro Trp Pro Ser Ser Thr Arg Ser Gly Ile Phe Leu
        515                 520                 525             
Trp Thr Lys Val Arg Asn Val Val Arg Gly Leu Ala Gln Phe Arg Gln
    530                 535                 540                 
Pro Leu Lys Lys Thr Val Gln Arg Ser Gln Val Ser Ser Ile Ser Gly
545                 550                 555                 560 
Gly Gln Ser Asp Gln Gly Tyr Gly Ser Lys Asp Glu Leu Ile Lys Asp
                565                 570                 575     
Asp Ala Glu Ile His Val Pro Glu Glu Gln Ala Ala Arg Glu Leu Ile
            580                 585                 590         
Thr Lys Thr Lys Met Gln Thr Glu Glu Val Cys Asp Ala Ser Ala Ile
        595                 600                 605             
Val Ala Lys His Ser Gln Pro Ser Pro Glu Pro His Ser Pro Thr Glu
    610                 615                 620                 
Pro Pro Ala Trp Gly Ser Ser Ile Val Lys Val Pro Ser Gly Ile Phe
625                 630                 635                 640 
Asp Val Asn Ser Arg Lys Ser Ser Thr Gly Ser Ile Ser Asn Val Leu
                645                 650                 655     
Phe Ser Thr Gln Asp Pro Val Glu Asp Ala Val Phe Gly Glu Ala Thr
            660                 665                 670         
Asn Leu Lys Lys Asn Gly Asp Arg Gly Glu Lys Arg Gln Lys His Phe
        675                 680                 685             
Pro Glu Arg Ser Cys Ser Phe Ser Ser Glu Ser Arg Ala Gly Met Leu
    690                 695                 700                 
Leu Lys Lys Ser Ser Leu Asp Ser Asn Ser Ser Glu Met Ala Ile Met
705                 710                 715                 720 
Met Gly Ala Asp Ala Lys Ile Leu Thr Ala Ala Leu Thr Cys Pro Lys
                725                 730                 735     
Thr Ser Leu Leu His Ile Ala Arg Thr His Ser Phe Glu Asn Val Ser
            740                 745                 750         
Cys His Leu Pro Asp Ser Arg Thr Cys Met Ser Glu Ser Thr Trp Asn
        755                 760                 765             
Pro Glu His Arg Ser Ser Pro Val Pro Glu Met Leu Glu Glu Ser Gln
    770                 775                 780                 
Glu Leu Leu Glu Pro Val Val Asp Asp Val Pro Lys Thr Thr Ala Thr
785                 790                 795                 800 
Val Asp Thr Tyr Glu Ser Leu Leu Ser Asp Ser Asn Ser Asn Gln Ser
                805                 810                 815     
Arg Asp Leu Lys Thr Val Ser Lys Asp Leu Arg Asn Lys Arg Ser Ser
            820                 825                 830         
Leu Tyr Gly Ile Ala Lys Val Val Gln Arg Glu Asp Val Glu Thr Gly
        835                 840                 845             
Leu Asp Pro Leu Ser Leu Leu Ala Thr Glu Cys Thr Gly Gly Lys Thr
    850                 855                 860                 
Pro Asp Ser Glu Asp Lys Leu Phe Ser Pro Val Ile Ala Arg Asn Leu
865                 870                 875                 880 
Ala Asp Glu Ile Glu Ser Tyr Met Asn Leu Lys Ser Pro Leu Gly Ser
                885                 890                 895     
Lys Ser Ser Ser Met Glu Leu His Arg Glu Glu Asn Arg Glu Ser Gly
            900                 905                 910         
Met Thr Thr Ala Phe Ile His Ala Leu Glu Arg Arg Ser Ser Leu Pro
        915                 920                 925             
Leu Asp His Gly Ser Pro Ala Gln Glu Asn Pro Glu Ser Glu Lys Ser
    930                 935                 940                 
Ser Pro Ala Val Ser Arg Ser Lys Thr Phe Thr Gly Arg Phe Lys Gln
945                 950                 955                 960 
Gln Thr Pro Ser Arg Thr His Lys Glu Arg Ser Thr Ser Leu Ser Ala
                965                 970                 975     
Leu Val Arg Ser Ser Pro His Gly Ser Leu Gly Ser Val Val Asn Ser
            980                 985                 990         
Leu Ser Gly Leu Lys Leu Asp Asn Ile Leu Ser Gly Pro Lys Ile Asp
        995                 1000                1005            
Val Leu Lys Ser Gly Met Lys Gln Ala Ala Thr Val Ala Ser Lys Met
    1010                1015                1020                
Trp Val Ala Val Ala Ser Ala Tyr Ser Tyr Ser Asp Asp Glu Glu Glu
1025                1030                1035                1040
Thr Asn Arg Asp Tyr Ser Phe Pro Ala Gly Leu Glu Asp His Ile Leu
                1045                1050                1055    
Gly Glu Asn Ile Ser Pro Asn Thr Ser Ile Ser Gly Leu Val Pro Ser
            1060                1065                1070        
Glu Leu Thr Gln Ser Asn Thr Ser Leu Gly Ser Ser Ser Ser Ser Gly
        1075                1080                1085            
Asp Val Gly Lys Leu His Tyr Pro Thr Gly Glu Val Pro Phe Pro Arg
    1090                1095                1100                
Gly Met Lys Gly Gln Asp Phe Glu Lys Ser Asp His Gly Ser Ser Gln
1105                1110                1115                1120
Asn Thr Ser Met Ser Ser Ile Tyr Gln Asn Cys Ala Met Glu Val Leu
                1125                1130                1135    
Met Ser Ser Cys Ser Gln Cys Arg Ala Cys Gly Ala Leu Val Tyr Asp
            1140                1145                1150        
Glu Glu Ile Met Ala Gly Trp Thr Ala Asp Asp Ser Asn Leu Asn Thr
        1155                1160                1165            
Ala Cys Pro Phe Cys Lys Ser Asn Phe Leu Pro Leu Leu Asn Ile Glu
    1170                1175                1180                
Phe Lys Asp Leu Arg Gly Ser Ala Ser Phe Phe Leu Lys Pro Ser Thr
1185                1190                1195                1200
Ser Gly Asp Ser Leu Gln Ser Gly Ser Ile Pro Leu Ala Asn Glu Ser
                1205                1210                1215    
Leu Glu His Lys Pro Val Ser Ser Leu Ala Glu Pro Asp Leu Ile Asn
            1220                1225                1230        
Phe Met Asp Phe Pro Lys His Asn Gln Ile Ile Thr Glu Glu Thr Gly
        1235                1240                1245            
Ser Ala Val Glu Pro Ser Asp Glu Ile Lys Arg Ala Ser Gly Asp Val
    1250                1255                1260                
Gln Thr Met Lys Ile Ser Ser Val Pro Asn Ser Leu Ser Lys Arg Asn
1265                1270                1275                1280
Val Ser Leu Thr Arg Ser His Ser Val Gly Gly Pro Leu Gln Asn Ile
                1285                1290                1295    
Asp Phe Thr Gln Arg Pro Phe His Gly Ile Ser Thr Val Ser Leu Pro
            1300                1305                1310        
Asn Ser Leu Gln Glu Val Val Asp Pro Leu Gly Lys Arg Pro Asn Pro
        1315                1320                1325            
Pro Pro Val Ser Val Pro Tyr Leu Ser Pro Leu Val Leu Arg Lys Glu
    1330                1335                1340                
Leu Glu Ser Leu Leu Glu Asn Glu Gly Asp Gln Val Ile His Thr Ser
1345                1350                1355                1360
Ser Phe Ile Asn Gln His Pro Ile Ile Phe Trp Asn Leu Val Trp Tyr
                1365                1370                1375    
Phe Arg Arg Leu Asp Leu Pro Ser Asn Leu Pro Gly Leu Ile Leu Thr
            1380                1385                1390        
Ser Glu His Cys Asn Glu Gly Val Gln Leu Pro Leu Ser Ser Leu Ser
        1395                1400                1405            
Gln Asp Ser Lys Leu Val Tyr Ile Gln Leu Leu Trp Asp Asn Ile Asn
    1410                1415                1420                
Leu His Gln Glu Pro Arg Glu Pro Leu Tyr Val Ser Trp Arg Asn Phe
1425                1430                1435                1440
Asn Ser Glu Lys Lys Ser Ser Leu Leu Ser Glu Glu Gln Gln Glu Thr
                1445                1450                1455    
Ser Thr Leu Val Glu Thr Ile Arg Gln Ser Ile Gln His Asn Asn Val
            1460                1465                1470        
Leu Lys Pro Ile Asn Leu Leu Ser Gln Gln Met Lys Pro Gly Met Lys
        1475                1480                1485            
Arg Gln Arg Ser Leu Tyr Arg Glu Ile Leu Phe Leu Ser Leu Val Ser
    1490                1495                1500                
Leu Gly Arg Glu Asn Ile Asp Ile Glu Ala Phe Asp Asn Glu Tyr Gly
1505                1510                1515                1520
Ile Ala Tyr Asn Ser Leu Ser Ser Glu Ile Leu Glu Arg Leu Gln Lys
                1525                1530                1535    
Ile Asp Ala Pro Pro Ser Ala Ser Val Glu Trp Cys Arg Lys Cys Phe
            1540                1545                1550        
Gly Ala Pro Leu Ile
        1555        


<210> 6745
<211> 1179
<212> PRT
<213> Homo sapiens

<400> 6745
Met Asp Arg Leu Asp Arg Ile Leu Leu Ser Gly Ile Tyr Asn Val Arg
 1               5                  10                  15      
Lys Gly Lys Thr Gln Leu His Lys Trp Ala Glu Arg Leu Val Val Leu
            20                  25                  30          
Cys Gly Thr Cys Leu Ile Val Ser Ser Val Lys Asp Cys Gln Thr Gly
        35                  40                  45              
Lys Met His Ile Leu Pro Leu Val Gly Gly Lys Ile Glu Glu Val Lys
    50                  55                  60                  
Arg Arg Gln Tyr Ser Leu Ala Phe Ser Ser Ala Gly Ala Gln Ala Gln
65                  70                  75                  80  
Thr Tyr His Val Ser Phe Glu Thr Leu Ala Glu Tyr Gln Arg Trp Gln
                85                  90                  95      
Arg Gln Ala Ser Lys Val Val Ser Gln Arg Ile Ser Thr Val Asp Leu
            100                 105                 110         
Ser Cys Tyr Ser Leu Glu Glu Val Pro Glu His Leu Phe Tyr Ser Gln
        115                 120                 125             
Asp Ile Thr Tyr Leu Asn Leu Arg His Asn Phe Met Gln Leu Glu Arg
    130                 135                 140                 
Pro Gly Gly Leu Asp Thr Leu Tyr Lys Phe Ser Gln Leu Lys Gly Leu
145                 150                 155                 160 
Asn Leu Ser His Asn Lys Leu Gly Leu Phe Pro Ile Leu Leu Cys Glu
                165                 170                 175     
Ile Ser Thr Leu Thr Glu Leu Asn Leu Ser Cys Asn Gly Phe His Asp
            180                 185                 190         
Leu Pro Ser Gln Ile Gly Asn Leu Leu Asn Leu Gln Thr Leu Cys Leu
        195                 200                 205             
Asp Gly Asn Phe Leu Thr Thr Leu Pro Glu Glu Leu Gly Asn Leu Gln
    210                 215                 220                 
Gln Leu Ser Ser Leu Gly Ile Ser Phe Asn Asn Phe Ser Gln Ile Pro
225                 230                 235                 240 
Glu Val Tyr Glu Lys Leu Thr Met Leu Asp Arg Val Val Met Ala Gly
                245                 250                 255     
Asn Cys Leu Glu Val Leu Asn Leu Gly Val Leu Asn Arg Met Asn His
            260                 265                 270         
Ile Lys His Val Asp Leu Arg Met Asn His Leu Lys Thr Met Val Ile
        275                 280                 285             
Glu Asn Leu Glu Gly Asn Lys His Ile Thr His Val Asp Leu Arg Asp
    290                 295                 300                 
Asn Arg Leu Thr Asp Leu Asp Leu Ser Ser Leu Cys Ser Leu Glu Gln
305                 310                 315                 320 
Leu His Cys Gly Arg Asn Gln Leu Arg Glu Leu Thr Leu Ser Gly Phe
                325                 330                 335     
Ser Leu Arg Thr Leu Tyr Ala Ser Ser Asn Arg Leu Thr Ala Val Asn
            340                 345                 350         
Val Tyr Pro Val Pro Ser Leu Leu Thr Phe Leu Asp Leu Ser Arg Asn
        355                 360                 365             
Leu Leu Glu Cys Val Pro Asp Trp Ala Cys Glu Ala Lys Lys Ile Glu
    370                 375                 380                 
Val Leu Asp Val Ser Tyr Asn Leu Leu Thr Glu Val Pro Val Arg Ile
385                 390                 395                 400 
Leu Ser Ser Leu Ser Leu Arg Lys Leu Met Leu Gly His Asn His Val
                405                 410                 415     
Gln Asn Leu Pro Thr Leu Val Glu His Ile Pro Leu Glu Val Leu Asp
            420                 425                 430         
Leu Gln His Asn Ala Leu Thr Arg Leu Pro Asp Thr Leu Phe Ser Lys
        435                 440                 445             
Ala Leu Asn Leu Arg Tyr Leu Asn Ala Ser Ala Asn Ser Leu Glu Ser
    450                 455                 460                 
Leu Pro Ser Ala Cys Thr Gly Glu Glu Ser Leu Ser Met Leu Gln Leu
465                 470                 475                 480 
Leu Tyr Leu Thr Asn Asn Leu Leu Thr Asp Gln Cys Ile Pro Val Leu
                485                 490                 495     
Val Gly His Leu His Leu Arg Ile Leu His Leu Ala Asn Asn Gln Leu
            500                 505                 510         
Gln Thr Phe Pro Ala Ser Lys Leu Asn Lys Leu Glu Gln Leu Glu Glu
        515                 520                 525             
Leu Asn Leu Ser Gly Asn Lys Leu Lys Thr Ile Pro Thr Thr Ile Ala
    530                 535                 540                 
Asn Cys Lys Arg Leu His Thr Leu Val Ala His Ser Asn Asn Ile Ser
545                 550                 555                 560 
Ile Phe Pro Glu Ile Leu Gln Leu Pro Gln Ile Gln Phe Val Asp Leu
                565                 570                 575     
Ser Cys Asn Asp Leu Thr Glu Ile Leu Ile Pro Glu Ala Leu Pro Ala
            580                 585                 590         
Thr Leu Gln Asp Leu Asp Leu Thr Gly Asn Thr Asn Leu Val Leu Glu
        595                 600                 605             
His Lys Thr Leu Asp Ile Phe Ser His Ile Thr Thr Leu Lys Ile Asp
    610                 615                 620                 
Gln Lys Pro Leu Pro Thr Thr Asp Ser Thr Val Thr Ser Thr Phe Trp
625                 630                 635                 640 
Ser His Gly Leu Ala Glu Met Ala Gly Gln Arg Asn Lys Leu Cys Val
                645                 650                 655     
Ser Ala Leu Ala Met Asp Ser Phe Ala Glu Gly Val Gly Ala Val Tyr
            660                 665                 670         
Gly Met Phe Asp Gly Asp Arg Asn Glu Glu Leu Pro Arg Leu Leu Gln
        675                 680                 685             
Cys Thr Met Ala Asp Val Leu Leu Glu Glu Val Gln Gln Ser Thr Asn
    690                 695                 700                 
Asp Thr Val Phe Met Ala Asn Thr Phe Leu Val Ser His Arg Lys Leu
705                 710                 715                 720 
Gly Met Ala Gly Gln Lys Leu Gly Ser Ser Ala Leu Leu Cys Tyr Ile
                725                 730                 735     
Arg Pro Asp Thr Ala Asp Pro Ala Ser Ser Phe Ser Leu Thr Val Ala
            740                 745                 750         
Asn Val Gly Thr Cys Gln Ala Val Leu Cys Arg Gly Gly Lys Pro Val
        755                 760                 765             
Pro Leu Ser Lys Val Phe Ser Leu Glu Gln Asp Pro Glu Glu Ala Gln
    770                 775                 780                 
Arg Val Lys Asp Gln Lys Ala Ile Ile Thr Glu Asp Asn Lys Val Asn
785                 790                 795                 800 
Gly Val Thr Cys Cys Thr Arg Met Leu Gly Cys Thr Tyr Leu Tyr Pro
                805                 810                 815     
Trp Ile Leu Pro Lys Pro His Ile Ser Ser Thr Pro Leu Thr Ile Gln
            820                 825                 830         
Asp Glu Leu Leu Ile Leu Gly Asn Lys Ala Leu Trp Glu His Leu Ser
        835                 840                 845             
Tyr Thr Glu Ala Val Asn Ala Val Arg His Val Gln Asp Pro Leu Ala
    850                 855                 860                 
Ala Ala Lys Lys Leu Cys Thr Leu Ala Gln Ser Tyr Gly Cys Gln Asp
865                 870                 875                 880 
Asn Val Gly Ala Met Val Val Tyr Leu Asn Ile Gly Glu Glu Gly Cys
                885                 890                 895     
Thr Cys Glu Met Asn Gly Leu Thr Leu Pro Gly Pro Val Gly Phe Ala
            900                 905                 910         
Ser Thr Thr Thr Ile Lys Asp Ala Pro Lys Pro Ala Thr Pro Ser Ser
        915                 920                 925             
Ser Ser Gly Ile Ala Ser Glu Phe Ser Ser Glu Met Ser Thr Ser Glu
    930                 935                 940                 
Val Ser Ser Glu Val Gly Ser Thr Ala Ser Asp Glu His Asn Ala Gly
945                 950                 955                 960 
Gly Leu Asp Thr Ala Leu Leu Pro Arg Pro Glu Arg Arg Cys Ser Leu
                965                 970                 975     
His Pro Thr Pro Thr Ser Gly Leu Phe Gln Arg Gln Pro Ser Ser Ala
            980                 985                 990         
Thr Phe Ser Ser Asn Gln Ser Asp Asn Gly Leu Asp Ser Asp Asp Asp
        995                 1000                1005            
Gln Pro Val Glu Gly Val Ile Thr Asn Gly Ser Lys Val Glu Val Glu
    1010                1015                1020                
Val Asp Ile His Cys Cys Arg Gly Arg Asp Leu Glu Asn Ser Pro Pro
1025                1030                1035                1040
Leu Ile Glu Ser Ser Pro Thr Leu Cys Ser Glu Glu His Ala Arg Gly
                1045                1050                1055    
Ser Cys Phe Gly Ile Arg Arg Gln Asn Ser Val Asn Ser Gly Met Leu
            1060                1065                1070        
Leu Pro Met Ser Lys Asp Arg Met Glu Leu Gln Lys Ser Pro Ser Thr
        1075                1080                1085            
Ser Cys Leu Tyr Gly Lys Lys Leu Ser Asn Gly Ser Ile Val Pro Leu
    1090                1095                1100                
Glu Asp Ser Leu Asn Leu Ile Glu Val Ala Thr Glu Val Pro Lys Arg
1105                1110                1115                1120
Lys Thr Gly Tyr Phe Ala Ala Pro Thr Gln Met Glu Pro Glu Asp Gln
                1125                1130                1135    
Phe Val Val Pro His Asp Leu Glu Glu Glu Val Lys Glu Gln Met Lys
            1140                1145                1150        
Gln His Gln Asp Ser Arg Leu Glu Pro Glu Pro His Glu Glu Asp Arg
        1155                1160                1165            
Thr Glu Pro Pro Glu Glu Phe Asp Thr Ala Leu
    1170                1175                


<210> 6746
<211> 672
<212> PRT
<213> Homo sapiens

<400> 6746
Met Arg Ser Ile Arg Ser Phe Ala Asn Asp Asp Arg His Val Met Val
 1               5                  10                  15      
Lys His Ser Thr Ile Tyr Pro Ser Pro Glu Glu Leu Glu Ala Val Gln
            20                  25                  30          
Asn Met Val Ser Thr Val Glu Cys Ala Leu Lys His Val Ser Asp Trp
        35                  40                  45              
Leu Asp Glu Thr Asn Lys Gly Thr Lys Thr Glu Gly Glu Thr Glu Val
    50                  55                  60                  
Lys Lys Asp Glu Ala Gly Glu Asn Tyr Ser Lys Asp Gln Gly Gly Arg
65                  70                  75                  80  
Thr Leu Cys Gly Val Met Arg Ile Gly Leu Val Ala Lys Gly Leu Leu
                85                  90                  95      
Ile Lys Asp Asp Met Asp Leu Glu Leu Val Leu Met Cys Lys Asp Lys
            100                 105                 110         
Pro Thr Glu Thr Leu Leu Asn Thr Val Lys Asp Asn Leu Pro Ile Gln
        115                 120                 125             
Ile Gln Lys Leu Thr Glu Glu Lys Tyr Gln Val Glu Gln Cys Val Asn
    130                 135                 140                 
Glu Ala Ser Ile Ile Ile Arg Asn Thr Lys Glu Pro Thr Leu Thr Leu
145                 150                 155                 160 
Lys Val Ile Leu Thr Ser Pro Leu Ile Arg Asp Glu Leu Glu Lys Lys
                165                 170                 175     
Asp Gly Glu Asn Val Ser Met Lys Asp Pro Pro Asp Leu Leu Asp Arg
            180                 185                 190         
Gln Lys Cys Leu Asn Ala Leu Ala Ser Leu Arg His Ala Lys Trp Phe
        195                 200                 205             
Gln Ala Arg Ala Asn Gly Leu Lys Ser Cys Val Ile Val Leu Arg Ile
    210                 215                 220                 
Leu Arg Asp Leu Cys Asn Arg Val Pro Thr Trp Ala Pro Leu Lys Gly
225                 230                 235                 240 
Trp Pro Leu Glu Leu Ile Cys Glu Lys Ser Ile Gly Thr Cys Asn Arg
                245                 250                 255     
Pro Leu Gly Ala Gly Glu Ala Leu Arg Arg Val Met Glu Cys Leu Ala
            260                 265                 270         
Ser Gly Ile Leu Leu Pro Gly Gly Pro Gly Leu His Asp Pro Cys Glu
        275                 280                 285             
Arg Asp Pro Thr Asp Ala Leu Ser Tyr Met Thr Ile Gln Gln Lys Glu
    290                 295                 300                 
Asp Ile Thr His Ser Ala Gln His Ala Leu Arg Leu Ser Ala Phe Gly
305                 310                 315                 320 
Gln Ile Tyr Lys Val Leu Glu Met Asp Pro Leu Pro Ser Ser Lys Pro
                325                 330                 335     
Phe Gln Lys Tyr Ser Trp Ser Val Thr Asp Lys Glu Gly Ala Gly Ser
            340                 345                 350         
Ser Ala Leu Lys Arg Pro Phe Glu Asp Gly Leu Gly Asp Asp Lys Asp
        355                 360                 365             
Pro Asn Lys Lys Met Lys Arg Asn Leu Arg Lys Ile Leu Asp Ser Lys
    370                 375                 380                 
Ala Ile Asp Leu Met Asn Ala Leu Met Arg Leu Asn Gln Ile Arg Pro
385                 390                 395                 400 
Gly Leu Gln Tyr Lys Leu Leu Ser Gln Ser Gly Pro Val His Ala Pro
                405                 410                 415     
Val Phe Thr Met Ser Val Asp Val Asp Gly Thr Thr Tyr Glu Ala Ser
            420                 425                 430         
Gly Pro Ser Lys Lys Thr Ala Lys Leu His Val Ala Val Lys Val Leu
        435                 440                 445             
Gln Ala Met Gly Tyr Pro Thr Gly Phe Asp Ala Asp Ile Glu Cys Met
    450                 455                 460                 
Ser Ser Asp Glu Lys Ser Asp Asn Glu Ser Lys Asn Glu Thr Val Ser
465                 470                 475                 480 
Ser Asn Ser Ser Asn Asn Thr Gly Asn Ser Thr Thr Glu Thr Ser Ser
                485                 490                 495     
Thr Leu Glu Val Arg Thr Gln Gly Pro Ile Leu Thr Ala Ser Gly Lys
            500                 505                 510         
Asn Pro Val Met Glu Leu Asn Glu Lys Arg Arg Gly Leu Lys Tyr Glu
        515                 520                 525             
Leu Ile Ser Glu Thr Gly Gly Ser His Asp Lys Arg Phe Val Met Glu
    530                 535                 540                 
Val Glu Val Asp Gly Gln Lys Phe Arg Gly Ala Gly Pro Asn Lys Lys
545                 550                 555                 560 
Val Ala Lys Ala Ser Ala Ala Leu Ala Ala Leu Glu Lys Leu Phe Ser
                565                 570                 575     
Gly Pro Asn Ala Ala Asn Asn Lys Lys Lys Lys Ile Ile Pro Gln Ala
            580                 585                 590         
Lys Gly Val Val Asn Thr Ala Val Ser Ala Ala Val Gln Ala Val Arg
        595                 600                 605             
Gly Arg Gly Arg Gly Thr Leu Thr Arg Gly Ala Phe Val Gly Ala Thr
    610                 615                 620                 
Ala Ala Pro Gly Tyr Ile Ala Pro Gly Tyr Gly Thr Pro Tyr Gly Tyr
625                 630                 635                 640 
Ser Thr Ala Ala Pro Ala Tyr Gly Leu Pro Lys Arg Met Val Leu Leu
                645                 650                 655     
Pro Val Met Lys Phe Pro Thr Tyr Pro Val Pro His Tyr Ser Phe Phe
            660                 665                 670         


<210> 6747
<211> 530
<212> PRT
<213> Homo sapiens

<400> 6747
Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser
 1               5                  10                  15      
Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn
            20                  25                  30          
Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro
        35                  40                  45              
Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn
    50                  55                  60                  
Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr
65                  70                  75                  80  
Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp
                85                  90                  95      
Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn
            100                 105                 110         
Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro
        115                 120                 125             
Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu
    130                 135                 140                 
Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg
145                 150                 155                 160 
Leu Glu Arg Ile Val His Gly Ser Asn Lys Ile Lys Phe Val Val Lys
                165                 170                 175     
Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys
            180                 185                 190         
Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly
        195                 200                 205             
Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn
    210                 215                 220                 
Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn
225                 230                 235                 240 
Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu
                245                 250                 255     
Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu
            260                 265                 270         
Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys
        275                 280                 285             
Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu
    290                 295                 300                 
Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile
305                 310                 315                 320 
Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile
                325                 330                 335     
Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser
            340                 345                 350         
Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr
        355                 360                 365             
Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro
    370                 375                 380                 
Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu
385                 390                 395                 400 
Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile
                405                 410                 415     
Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn
            420                 425                 430         
Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys
        435                 440                 445             
Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser
    450                 455                 460                 
Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val
465                 470                 475                 480 
Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile
                485                 490                 495     
Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu
            500                 505                 510         
Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro
        515                 520                 525             
Thr Trp
    530 


<210> 6748
<211> 957
<212> PRT
<213> Homo sapiens

<400> 6748
Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser
 1               5                  10                  15      
Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser
            20                  25                  30          
Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala
        35                  40                  45              
Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala
    50                  55                  60                  
Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys
65                  70                  75                  80  
Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr
                85                  90                  95      
Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu
            100                 105                 110         
Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu
        115                 120                 125             
Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp
    130                 135                 140                 
Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys
145                 150                 155                 160 
His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn
                165                 170                 175     
Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys
            180                 185                 190         
Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile
        195                 200                 205             
Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro
    210                 215                 220                 
Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys
225                 230                 235                 240 
Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser
                245                 250                 255     
His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala
            260                 265                 270         
Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu
        275                 280                 285             
Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys
    290                 295                 300                 
Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu
305                 310                 315                 320 
Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile
                325                 330                 335     
Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His
            340                 345                 350         
Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg
        355                 360                 365             
Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala
    370                 375                 380                 
Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser
385                 390                 395                 400 
Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu
                405                 410                 415     
Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu
            420                 425                 430         
Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala
        435                 440                 445             
Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu
    450                 455                 460                 
Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile
465                 470                 475                 480 
Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val
                485                 490                 495     
Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln
            500                 505                 510         
Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr
        515                 520                 525             
Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln
    530                 535                 540                 
Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu
545                 550                 555                 560 
Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro
                565                 570                 575     
Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val
            580                 585                 590         
Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val
        595                 600                 605             
Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala
    610                 615                 620                 
Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val
625                 630                 635                 640 
Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln
                645                 650                 655     
Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro
            660                 665                 670         
Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys
        675                 680                 685             
Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys
    690                 695                 700                 
Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu
705                 710                 715                 720 
Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly
                725                 730                 735     
Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys
            740                 745                 750         
Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu
        755                 760                 765             
Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro
    770                 775                 780                 
Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val
785                 790                 795                 800 
Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu
                805                 810                 815     
Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn
            820                 825                 830         
Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro
        835                 840                 845             
Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val
    850                 855                 860                 
Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu
865                 870                 875                 880 
Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys
                885                 890                 895     
Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu
            900                 905                 910         
Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu
        915                 920                 925             
Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp
    930                 935                 940                 
Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp
945                 950                 955         


<210> 6749
<211> 998
<212> PRT
<213> Homo sapiens

<400> 6749
Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser
 1               5                  10                  15      
Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser
            20                  25                  30          
Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala
        35                  40                  45              
Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala
    50                  55                  60                  
Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys
65                  70                  75                  80  
Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr
                85                  90                  95      
Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu
            100                 105                 110         
Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu
        115                 120                 125             
Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp
    130                 135                 140                 
Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys
145                 150                 155                 160 
His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn
                165                 170                 175     
Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys
            180                 185                 190         
Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile
        195                 200                 205             
Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro
    210                 215                 220                 
Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys
225                 230                 235                 240 
Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly
                245                 250                 255     
Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro
            260                 265                 270         
Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met
        275                 280                 285             
Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser
    290                 295                 300                 
Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro
305                 310                 315                 320 
Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro
                325                 330                 335     
Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu
            340                 345                 350         
Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu
        355                 360                 365             
Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr
    370                 375                 380                 
Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu
385                 390                 395                 400 
Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile
                405                 410                 415     
Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val
            420                 425                 430         
Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu
        435                 440                 445             
Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr
    450                 455                 460                 
Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu
465                 470                 475                 480 
Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu
                485                 490                 495     
Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro
            500                 505                 510         
Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile
        515                 520                 525             
Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu
    530                 535                 540                 
Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val
545                 550                 555                 560 
Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu
                565                 570                 575     
Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala
            580                 585                 590         
Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr
        595                 600                 605             
Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe
    610                 615                 620                 
Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys
625                 630                 635                 640 
Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly
                645                 650                 655     
Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro
            660                 665                 670         
Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val
        675                 680                 685             
Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro
    690                 695                 700                 
Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu
705                 710                 715                 720 
Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys
                725                 730                 735     
Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys
            740                 745                 750         
Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp
        755                 760                 765             
Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser
    770                 775                 780                 
Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys
785                 790                 795                 800 
Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys
                805                 810                 815     
Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro
            820                 825                 830         
Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln
        835                 840                 845             
Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys
    850                 855                 860                 
Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe
865                 870                 875                 880 
Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys
                885                 890                 895     
Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly
            900                 905                 910         
Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg
        915                 920                 925             
Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe
    930                 935                 940                 
Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu
945                 950                 955                 960 
Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro
                965                 970                 975     
Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln
            980                 985                 990         
Glu Pro Asp Pro Thr Trp
        995             


<210> 6750
<211> 718
<212> PRT
<213> Homo sapiens

<400> 6750
Met Arg Cys Thr Glu Gly Ser Gln Gln Ser Glu Phe Leu Val Tyr Pro
 1               5                  10                  15      
Gln Gly Asn Glu His Gly Thr Leu Thr Thr Ala Asn Asp His Phe Leu
            20                  25                  30          
Phe Gln Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn
        35                  40                  45              
Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg
    50                  55                  60                  
Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp
65                  70                  75                  80  
Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala
                85                  90                  95      
Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser
            100                 105                 110         
His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe
        115                 120                 125             
Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu
    130                 135                 140                 
Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn
145                 150                 155                 160 
Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys
                165                 170                 175     
Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln
            180                 185                 190         
Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys
        195                 200                 205             
Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val
    210                 215                 220                 
Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly
225                 230                 235                 240 
Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe
                245                 250                 255     
Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr
            260                 265                 270         
Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile
        275                 280                 285             
Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala
    290                 295                 300                 
Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe
305                 310                 315                 320 
Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile
                325                 330                 335     
Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile
            340                 345                 350         
Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu
        355                 360                 365             
Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys
    370                 375                 380                 
Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys
385                 390                 395                 400 
Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro
                405                 410                 415     
Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val
            420                 425                 430         
Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala
        435                 440                 445             
Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys
    450                 455                 460                 
Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala
465                 470                 475                 480 
Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu
                485                 490                 495     
Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu
            500                 505                 510         
Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro
        515                 520                 525             
Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro
    530                 535                 540                 
Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly
545                 550                 555                 560 
Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn
                565                 570                 575     
Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val
            580                 585                 590         
Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe
        595                 600                 605             
Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val
    610                 615                 620                 
Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr
625                 630                 635                 640 
Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile
                645                 650                 655     
Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln
            660                 665                 670         
Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala
        675                 680                 685             
Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr
    690                 695                 700                 
Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp
705                 710                 715             


<210> 6751
<211> 977
<212> PRT
<213> Homo sapiens

<400> 6751
Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser
 1               5                  10                  15      
Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser
            20                  25                  30          
Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala
        35                  40                  45              
Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala
    50                  55                  60                  
Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys
65                  70                  75                  80  
Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr
                85                  90                  95      
Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu
            100                 105                 110         
Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu
        115                 120                 125             
Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp
    130                 135                 140                 
Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys
145                 150                 155                 160 
His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn
                165                 170                 175     
Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys
            180                 185                 190         
Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile
        195                 200                 205             
Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro
    210                 215                 220                 
Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys
225                 230                 235                 240 
Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly
                245                 250                 255     
Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro
            260                 265                 270         
Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met
        275                 280                 285             
Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro
    290                 295                 300                 
Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala
305                 310                 315                 320 
Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg
                325                 330                 335     
Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr
            340                 345                 350         
Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu
        355                 360                 365             
Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly
    370                 375                 380                 
Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg
385                 390                 395                 400 
Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu
                405                 410                 415     
Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser
            420                 425                 430         
Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met
        435                 440                 445             
Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr
    450                 455                 460                 
Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp
465                 470                 475                 480 
Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser
                485                 490                 495     
Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg
            500                 505                 510         
Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr
        515                 520                 525             
Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn
    530                 535                 540                 
Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu
545                 550                 555                 560 
Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr
                565                 570                 575     
Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro
            580                 585                 590         
Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu
        595                 600                 605             
Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys
    610                 615                 620                 
Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile
625                 630                 635                 640 
Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser
                645                 650                 655     
Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn
            660                 665                 670         
Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly
        675                 680                 685             
Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala
    690                 695                 700                 
Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe
705                 710                 715                 720 
Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val
                725                 730                 735     
Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly
            740                 745                 750         
Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro
        755                 760                 765             
Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile
    770                 775                 780                 
Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser
785                 790                 795                 800 
Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr
                805                 810                 815     
Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp
            820                 825                 830         
Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg
        835                 840                 845             
Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly
    850                 855                 860                 
Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro
865                 870                 875                 880 
Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala
                885                 890                 895     
Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala
            900                 905                 910         
Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile
        915                 920                 925             
Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln
    930                 935                 940                 
Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile
945                 950                 955                 960 
Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr
                965                 970                 975     
Trp
    


<210> 6752
<211> 530
<212> PRT
<213> Homo sapiens

<400> 6752
Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser
 1               5                  10                  15      
Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn
            20                  25                  30          
Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro
        35                  40                  45              
Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn
    50                  55                  60                  
Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr
65                  70                  75                  80  
Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp
                85                  90                  95      
Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn
            100                 105                 110         
Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro
        115                 120                 125             
Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu
    130                 135                 140                 
Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg
145                 150                 155                 160 
Leu Glu Arg Ile Val His Gly Ser Asn Lys Ile Lys Phe Val Val Lys
                165                 170                 175     
Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys
            180                 185                 190         
Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly
        195                 200                 205             
Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn
    210                 215                 220                 
Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn
225                 230                 235                 240 
Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu
                245                 250                 255     
Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu
            260                 265                 270         
Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys
        275                 280                 285             
Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu
    290                 295                 300                 
Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile
305                 310                 315                 320 
Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile
                325                 330                 335     
Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser
            340                 345                 350         
Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr
        355                 360                 365             
Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro
    370                 375                 380                 
Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu
385                 390                 395                 400 
Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile
                405                 410                 415     
Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn
            420                 425                 430         
Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys
        435                 440                 445             
Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser
    450                 455                 460                 
Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val
465                 470                 475                 480 
Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Lys Gly Pro Val Ile
                485                 490                 495     
Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu
            500                 505                 510         
Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro
        515                 520                 525             
Thr Trp
    530 


<210> 6753
<211> 978
<212> PRT
<213> Homo sapiens

<400> 6753
Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser
 1               5                  10                  15      
Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser
            20                  25                  30          
Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala
        35                  40                  45              
Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala
    50                  55                  60                  
Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys
65                  70                  75                  80  
Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr
                85                  90                  95      
Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu
            100                 105                 110         
Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu
        115                 120                 125             
Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp
    130                 135                 140                 
Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys
145                 150                 155                 160 
His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn
                165                 170                 175     
Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys
            180                 185                 190         
Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile
        195                 200                 205             
Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro
    210                 215                 220                 
Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys
225                 230                 235                 240 
Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser
                245                 250                 255     
His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala
            260                 265                 270         
Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu
        275                 280                 285             
Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg
    290                 295                 300                 
Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn
305                 310                 315                 320 
Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala
                325                 330                 335     
Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys
            340                 345                 350         
Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro
        355                 360                 365             
Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu
    370                 375                 380                 
Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu
385                 390                 395                 400 
Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His
                405                 410                 415     
Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala
            420                 425                 430         
Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys
        435                 440                 445             
Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser
    450                 455                 460                 
Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn
465                 470                 475                 480 
Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro
                485                 490                 495     
Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn
            500                 505                 510         
Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr
        515                 520                 525             
Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp
    530                 535                 540                 
Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn
545                 550                 555                 560 
Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro
                565                 570                 575     
Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu
            580                 585                 590         
Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg
        595                 600                 605             
Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys
    610                 615                 620                 
Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys
625                 630                 635                 640 
Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly
                645                 650                 655     
Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn
            660                 665                 670         
Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn
        675                 680                 685             
Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu
    690                 695                 700                 
Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu
705                 710                 715                 720 
Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys
                725                 730                 735     
Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu
            740                 745                 750         
Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile
        755                 760                 765             
Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile
    770                 775                 780                 
Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser
785                 790                 795                 800 
Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr
                805                 810                 815     
Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro
            820                 825                 830         
Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu
        835                 840                 845             
Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile
    850                 855                 860                 
Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn
865                 870                 875                 880 
Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys
                885                 890                 895     
Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser
            900                 905                 910         
Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val
        915                 920                 925             
Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile
    930                 935                 940                 
Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu
945                 950                 955                 960 
Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro
                965                 970                 975     
Thr Trp
        


<210> 6754
<211> 437
<212> PRT
<213> Homo sapiens

<400> 6754
Arg Ser His Phe Ile Cys Asp Leu Asp Phe Phe Val Leu His Tyr Ile
 1               5                  10                  15      
Phe Ile Asp Phe Val Ile Asn Met Val Leu Gly Lys Val Lys Ser Leu
            20                  25                  30          
Thr Ile Ser Phe Asp Cys Leu Asn Asp Ser Asn Val Pro Val Tyr Ser
        35                  40                  45              
Ser Gly Asp Thr Val Ser Gly Arg Val Asn Leu Glu Val Thr Gly Glu
    50                  55                  60                  
Ile Arg Val Lys Ser Leu Lys Ile His Ala Arg Gly His Ala Lys Val
65                  70                  75                  80  
Arg Trp Thr Glu Ser Arg Asn Ala Gly Ser Asn Thr Ala Tyr Thr Gln
                85                  90                  95      
Asn Tyr Thr Glu Glu Val Glu Tyr Phe Asn His Lys Asp Ile Leu Ile
            100                 105                 110         
Gly His Glu Arg Asp Asp Asp Asn Ser Glu Glu Gly Phe His Thr Ile
        115                 120                 125             
His Ser Gly Arg His Glu Tyr Ala Phe Ser Phe Glu Leu Pro Gln Thr
    130                 135                 140                 
Pro Leu Ala Thr Ser Phe Glu Gly Arg His Gly Ser Val Arg Tyr Trp
145                 150                 155                 160 
Val Lys Ala Glu Leu His Arg Pro Trp Leu Leu Pro Val Lys Leu Lys
                165                 170                 175     
Lys Glu Phe Thr Val Phe Glu His Ile Asp Ile Asn Thr Pro Ser Leu
            180                 185                 190         
Leu Ser Pro Gln Ala Gly Thr Lys Glu Lys Thr Leu Cys Cys Trp Phe
        195                 200                 205             
Cys Thr Ser Gly Pro Ile Ser Leu Ser Ala Lys Ile Glu Arg Lys Gly
    210                 215                 220                 
Tyr Thr Pro Gly Glu Ser Ile Gln Ile Phe Ala Glu Ile Glu Asn Cys
225                 230                 235                 240 
Ser Ser Arg Met Val Val Pro Lys Ala Ala Ile Tyr Gln Thr Gln Ala
                245                 250                 255     
Phe Tyr Ala Lys Gly Lys Met Lys Glu Val Lys Gln Leu Val Ala Asn
            260                 265                 270         
Leu Arg Gly Glu Ser Leu Ser Ser Gly Lys Thr Glu Thr Trp Asn Gly
        275                 280                 285             
Lys Leu Leu Lys Ile Pro Pro Val Ser Pro Ser Ile Leu Asp Cys Ser
    290                 295                 300                 
Ile Ile Arg Val Glu Tyr Ser Leu Met Val Tyr Val Asp Ile Pro Gly
305                 310                 315                 320 
Ala Met Asp Leu Phe Leu Asn Leu Pro Leu Val Ile Gly Thr Ile Pro
                325                 330                 335     
Leu His Pro Phe Gly Ser Arg Thr Ser Ser Val Ser Ser Gln Cys Ser
            340                 345                 350         
Met Asn Met Asn Trp Leu Ser Leu Ser Leu Pro Glu Arg Pro Glu Ala
        355                 360                 365             
Pro Pro Ser Tyr Ala Glu Val Val Thr Glu Glu Gln Arg Arg Asn Asn
    370                 375                 380                 
Leu Ala Pro Val Ser Ala Cys Asp Asp Phe Glu Arg Ala Leu Gln Gly
385                 390                 395                 400 
Pro Leu Phe Ala Tyr Ile Gln Glu Phe Arg Phe Leu Pro Pro Pro Leu
                405                 410                 415     
Tyr Ser Glu Ile Asp Pro Asn Pro Asp Gln Ser Ala Asp Asp Arg Pro
            420                 425                 430         
Ser Cys Pro Ser Arg
        435         


<210> 6755
<211> 581
<212> PRT
<213> Homo sapiens

<400> 6755
Met Thr Ser Ala Val Val Asp Ser Gly Gly Thr Ile Leu Glu Leu Ser
 1               5                  10                  15      
Ser Asn Gly Val Glu Asn Gln Glu Glu Ser Glu Lys Val Ser Glu Tyr
            20                  25                  30          
Pro Ala Val Ile Val Glu Pro Val Pro Ser Ala Arg Leu Glu Gln Gly
        35                  40                  45              
Tyr Ala Ala Gln Val Leu Val Tyr Asp Asp Glu Thr Tyr Met Met Gln
    50                  55                  60                  
Asp Val Ala Glu Glu Gln Glu Val Glu Thr Glu Asn Val Glu Thr Val
65                  70                  75                  80  
Glu Ala Ser Val His Ser Ser Asn Ala His Cys Thr Asp Lys Thr Ile
                85                  90                  95      
Glu Ala Ala Glu Ala Leu Leu His Met Glu Ser Pro Thr Cys Leu Arg
            100                 105                 110         
Asp Ser Arg Ser Pro Glu Phe Ile His Ala Ala Met Arg Pro Asp Val
        115                 120                 125             
Ile Thr Glu Thr Val Val Glu Val Ser Thr Glu Glu Ser Glu Pro Met
    130                 135                 140                 
Asp Thr Ser Pro Ile Pro Thr Ser Pro Asp Ser His Glu Pro Met Lys
145                 150                 155                 160 
Lys Lys Lys Val Gly Arg Lys Pro Lys Thr Gln Gln Ser Pro Ile Ser
                165                 170                 175     
Asn Gly Ser Pro Glu Leu Gly Ile Lys Lys Lys Pro Arg Glu Gly Lys
            180                 185                 190         
Gly Asn Thr Thr Tyr Leu Trp Glu Phe Leu Leu Asp Leu Leu Gln Asp
        195                 200                 205             
Lys Asn Thr Cys Pro Arg Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly
    210                 215                 220                 
Ile Phe Lys Leu Val Asp Ser Lys Ala Val Ser Lys Leu Trp Gly Lys
225                 230                 235                 240 
His Lys Asn Lys Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu
                245                 250                 255     
Arg Tyr Tyr Tyr Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg
            260                 265                 270         
Leu Val Tyr Gln Phe Lys Asp Met Pro Lys Asn Ile Val Val Ile Asp
        275                 280                 285             
Asp Asp Lys Ser Glu Thr Cys Asn Glu Asp Leu Ala Gly Thr Thr Asp
    290                 295                 300                 
Glu Lys Ser Leu Glu Arg Val Ser Leu Ser Ala Glu Ser Leu Leu Lys
305                 310                 315                 320 
Ala Ala Ser Ser Val Arg Ser Gly Lys Asn Ser Ser Pro Ile Asn Cys
                325                 330                 335     
Ser Arg Ala Glu Lys Gly Val Ala Arg Val Val Asn Ile Thr Ser Pro
            340                 345                 350         
Gly His Asp Ala Ser Ser Arg Ser Pro Thr Thr Thr Ala Ser Val Ser
        355                 360                 365             
Ala Thr Ala Ala Pro Arg Thr Val Arg Val Ala Met Gln Val Pro Val
    370                 375                 380                 
Val Met Thr Ser Leu Gly Gln Lys Ile Ser Thr Val Ala Val Gln Ser
385                 390                 395                 400 
Val Asn Ala Gly Ala Pro Leu Ile Thr Ser Thr Ser Pro Thr Thr Ala
                405                 410                 415     
Thr Ser Pro Lys Val Val Ile Gln Thr Ile Pro Thr Val Met Pro Ala
            420                 425                 430         
Ser Thr Glu Asn Gly Asp Lys Ile Thr Met Gln Pro Ala Lys Ile Ile
        435                 440                 445             
Thr Ile Pro Ala Thr Gln Leu Ala Gln Cys Gln Leu Gln Thr Lys Ser
    450                 455                 460                 
Asn Leu Thr Gly Ser Gly Ser Ile Asn Ile Val Gly Thr Pro Leu Ala
465                 470                 475                 480 
Val Arg Ala Leu Thr Pro Val Ser Ile Ala His Gly Thr Pro Val Met
                485                 490                 495     
Arg Leu Ser Met Pro Thr Gln Gln Ala Ser Gly Gln Thr Pro Pro Arg
            500                 505                 510         
Val Ile Ser Ala Val Ile Lys Gly Pro Glu Val Lys Ser Glu Ala Val
        515                 520                 525             
Ala Lys Lys Gln Glu His Asp Val Lys Thr Leu Gln Leu Val Glu Glu
    530                 535                 540                 
Lys Pro Ala Asp Gly Asn Lys Thr Val Thr His Val Val Val Val Ser
545                 550                 555                 560 
Ala Pro Ser Ala Ile Ala Leu Pro Val Thr Met Lys Thr Glu Gly Leu
                565                 570                 575     
Val Thr Cys Glu Lys
            580     


<210> 6756
<211> 533
<212> PRT
<213> Homo sapiens

<400> 6756
Met Ala Thr Ser Leu His Glu Gly Pro Thr Asn Gln Leu Asp Leu Leu
 1               5                  10                  15      
Ile Arg Ala Val Glu Ala Ser Val His Ser Ser Asn Ala His Cys Thr
            20                  25                  30          
Asp Lys Thr Ile Glu Ala Ala Glu Ala Leu Leu His Met Glu Ser Pro
        35                  40                  45              
Thr Cys Leu Arg Asp Ser Arg Ser Pro Val Glu Val Phe Val Pro Pro
    50                  55                  60                  
Cys Val Ser Thr Pro Glu Phe Ile His Ala Ala Met Arg Pro Asp Val
65                  70                  75                  80  
Ile Thr Glu Thr Val Val Glu Val Ser Thr Glu Glu Ser Glu Pro Met
                85                  90                  95      
Asp Thr Ser Pro Ile Pro Thr Ser Pro Asp Ser His Glu Pro Met Lys
            100                 105                 110         
Lys Lys Lys Val Gly Arg Lys Pro Lys Thr Gln Gln Ser Pro Ile Ser
        115                 120                 125             
Asn Gly Ser Pro Glu Leu Gly Ile Lys Lys Lys Pro Arg Glu Gly Lys
    130                 135                 140                 
Gly Asn Thr Thr Tyr Leu Trp Glu Phe Leu Leu Asp Leu Leu Gln Asp
145                 150                 155                 160 
Lys Asn Thr Cys Pro Arg Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly
                165                 170                 175     
Ile Phe Lys Leu Val Asp Ser Lys Ala Val Ser Lys Leu Trp Gly Lys
            180                 185                 190         
His Lys Asn Lys Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu
        195                 200                 205             
Arg Tyr Tyr Tyr Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg
    210                 215                 220                 
Leu Val Tyr Gln Phe Lys Asp Met Pro Lys Asn Ile Val Val Ile Asp
225                 230                 235                 240 
Asp Asp Lys Ser Glu Thr Cys Asn Glu Asp Leu Ala Gly Thr Thr Asp
                245                 250                 255     
Glu Lys Ser Leu Glu Arg Val Ser Leu Ser Ala Glu Ser Leu Leu Lys
            260                 265                 270         
Ala Ala Ser Ser Val Arg Ser Gly Lys Asn Ser Ser Pro Ile Asn Cys
        275                 280                 285             
Ser Arg Ala Glu Lys Gly Val Ala Arg Val Val Asn Ile Thr Ser Pro
    290                 295                 300                 
Gly His Asp Ala Ser Ser Arg Ser Pro Thr Thr Thr Ala Ser Val Ser
305                 310                 315                 320 
Ala Thr Ala Ala Pro Arg Thr Val Arg Val Ala Met Gln Val Pro Val
                325                 330                 335     
Val Met Thr Ser Leu Gly Gln Lys Ile Ser Thr Val Ala Val Gln Ser
            340                 345                 350         
Val Asn Ala Gly Ala Pro Leu Ile Thr Ser Thr Ser Pro Thr Thr Ala
        355                 360                 365             
Thr Ser Pro Lys Val Val Ile Gln Thr Ile Pro Thr Val Met Pro Ala
    370                 375                 380                 
Ser Thr Glu Asn Gly Asp Lys Ile Thr Met Gln Pro Ala Lys Ile Ile
385                 390                 395                 400 
Thr Ile Pro Ala Thr Gln Leu Ala Gln Cys Gln Leu Gln Thr Lys Ser
                405                 410                 415     
Asn Leu Thr Gly Ser Gly Ser Ile Asn Ile Val Gly Thr Pro Leu Ala
            420                 425                 430         
Val Arg Ala Leu Thr Pro Val Ser Ile Ala His Gly Thr Pro Val Met
        435                 440                 445             
Arg Leu Ser Met Pro Thr Gln Gln Ala Ser Gly Gln Thr Pro Pro Arg
    450                 455                 460                 
Val Ile Ser Ala Val Ile Lys Gly Pro Glu Val Lys Ser Glu Ala Val
465                 470                 475                 480 
Ala Lys Lys Gln Glu His Asp Val Lys Thr Leu Gln Leu Val Glu Glu
                485                 490                 495     
Lys Pro Ala Asp Gly Asn Lys Thr Val Thr His Val Val Val Val Ser
            500                 505                 510         
Ala Pro Ser Ala Ile Ala Leu Pro Val Thr Met Lys Thr Glu Gly Leu
        515                 520                 525             
Val Thr Cys Glu Lys
    530             


<210> 6757
<211> 1079
<212> PRT
<213> Homo sapiens

<400> 6757
Met Asp Asp Asp Asp Asp Ser Cys Leu Leu Asp Leu Ile Gly Asp Pro
 1               5                  10                  15      
Gln Ala Leu Asn Tyr Phe Leu His Gly Pro Ser Asn Lys Ser Ser Asn
            20                  25                  30          
Asp Asp Leu Thr Asn Ala Gly Tyr Ser Ala Ala Asn Ser Asn Ser Ile
        35                  40                  45              
Phe Ala Asn Ser Ser Asn Ala Asp Pro Lys Ser Ser Leu Lys Gly Val
    50                  55                  60                  
Ser Asn Gln Leu Gly Glu Gly Pro Ser Asp Gly Leu Pro Leu Ser Ser
65                  70                  75                  80  
Ser Leu Gln Phe Leu Glu Asp Glu Leu Glu Ser Ser Pro Leu Pro Asp
                85                  90                  95      
Leu Thr Glu Asp Gln Pro Phe Asp Ile Leu Gln Lys Ser Leu Gln Glu
            100                 105                 110         
Ala Asn Ile Thr Glu Gln Thr Leu Ala Glu Glu Ala Tyr Leu Asp Ala
        115                 120                 125             
Ser Ile Gly Ser Ser Gln Gln Phe Ala Gln Ala Gln Leu His Pro Ser
    130                 135                 140                 
Ser Ser Ala Ser Phe Thr Gln Ala Ser Asn Val Ser Asn Tyr Ser Gly
145                 150                 155                 160 
Gln Thr Leu Gln Pro Ile Gly Val Thr His Val Pro Val Gly Ala Ser
                165                 170                 175     
Phe Ala Ser Asn Thr Val Gly Val Gln His Gly Phe Met Gln His Val
            180                 185                 190         
Gly Ile Ser Val Pro Ser Gln His Leu Ser Asn Ser Ser Gln Ile Ser
        195                 200                 205             
Gly Ser Gly Gln Ile Gln Leu Ile Gly Ser Phe Gly Asn His Pro Ser
    210                 215                 220                 
Met Met Thr Ile Asn Asn Leu Asp Gly Ser Gln Ile Ile Leu Lys Gly
225                 230                 235                 240 
Ser Gly Gln Gln Ala Pro Ser Asn Val Ser Gly Gly Leu Leu Val His
                245                 250                 255     
Arg Gln Thr Pro Asn Gly Asn Ser Leu Phe Gly Asn Ser Ser Ser Ser
            260                 265                 270         
Pro Val Ala Gln Pro Val Thr Val Pro Phe Asn Ser Thr Asn Phe Gln
        275                 280                 285             
Thr Ser Leu Pro Val His Asn Ile Ile Ile Gln Arg Gly Leu Ala Pro
    290                 295                 300                 
Asn Ser Asn Lys Val Pro Ile Asn Ile Gln Pro Lys Pro Ile Gln Met
305                 310                 315                 320 
Gly Gln Gln Asn Thr Tyr Asn Val Asn Asn Leu Gly Ile Gln Gln His
                325                 330                 335     
His Val Gln Gln Gly Ile Ser Phe Ala Ser Ala Ser Ser Pro Gln Gly
            340                 345                 350         
Ser Val Val Gly Pro His Met Ser Val Asn Ile Val Asn Gln Gln Asn
        355                 360                 365             
Thr Arg Lys Pro Val Thr Ser Gln Ala Val Ser Ser Thr Gly Gly Ser
    370                 375                 380                 
Ile Val Ile His Ser Pro Met Gly Gln Pro His Ala Pro Gln Ser Gln
385                 390                 395                 400 
Phe Leu Ile Pro Thr Ser Leu Ser Val Ser Ser Asn Ser Val His His
                405                 410                 415     
Val Gln Thr Ile Asn Gly Gln Leu Leu Gln Thr Gln Pro Ser Gln Leu
            420                 425                 430         
Ile Ser Gly Gln Val Ala Ser Glu His Val Met Leu Asn Arg Asn Ser
        435                 440                 445             
Ser Asn Met Leu Arg Thr Asn Gln Pro Tyr Thr Gly Pro Met Leu Asn
    450                 455                 460                 
Asn Gln Asn Thr Ala Val His Leu Val Ser Gly Gln Thr Phe Ala Ala
465                 470                 475                 480 
Ser Gly Ser Pro Val Ile Ala Asn His Ala Ser Pro Gln Leu Val Gly
                485                 490                 495     
Gly Gln Met Pro Leu Gln Gln Ala Ser Pro Thr Val Leu His Leu Ser
            500                 505                 510         
Pro Gly Gln Ser Ser Val Ser Gln Gly Arg Pro Gly Phe Ala Thr Met
        515                 520                 525             
Pro Ser Val Thr Ser Met Ser Gly Pro Ser Arg Phe Pro Ala Val Ser
    530                 535                 540                 
Ser Ala Ser Thr Ala His Pro Ser Leu Gly Ser Ala Val Gln Ser Gly
545                 550                 555                 560 
Ser Ser Gly Ser Asn Phe Thr Gly Asp Gln Leu Thr Gln Pro Asn Arg
                565                 570                 575     
Thr Pro Val Pro Val Ser Val Ser His Arg Leu Pro Val Ser Ser Ser
            580                 585                 590         
Lys Ser Thr Ser Thr Phe Ser Asn Thr Pro Gly Thr Gly Thr Gln Gln
        595                 600                 605             
Gln Phe Phe Cys Gln Ala Gln Lys Lys Cys Leu Asn Gln Thr Ser Pro
    610                 615                 620                 
Ile Ser Ala Pro Lys Thr Thr Asp Gly Leu Arg Gln Ala Gln Ile Pro
625                 630                 635                 640 
Gly Leu Leu Ser Thr Thr Leu Pro Gly Gln Asp Ser Gly Ser Lys Val
                645                 650                 655     
Ile Ser Ala Ser Leu Gly Thr Ala Gln Pro Gln Gln Glu Lys Val Val
            660                 665                 670         
Gly Ser Ser Pro Gly His Pro Ala Val Gln Val Glu Ser His Ser Gly
        675                 680                 685             
Gly Gln Lys Arg Pro Ala Ala Lys Gln Leu Thr Lys Gly Ala Phe Ile
    690                 695                 700                 
Leu Gln Gln Leu Gln Arg Asp Gln Ala His Thr Val Thr Pro Asp Lys
705                 710                 715                 720 
Ser His Phe Arg Ser Leu Ser Asp Ala Val Gln Arg Leu Leu Ser Tyr
                725                 730                 735     
His Val Cys Gln Gly Ser Met Pro Thr Glu Glu Asp Leu Arg Lys Val
            740                 745                 750         
Asp Asn Glu Phe Glu Thr Val Ala Thr Gln Leu Leu Lys Arg Thr Gln
        755                 760                 765             
Ala Met Leu Asn Lys Tyr Arg Cys Leu Leu Leu Glu Asp Ala Met Arg
    770                 775                 780                 
Ile Asn Pro Ser Ala Glu Met Val Met Ile Asp Arg Met Phe Asn Gln
785                 790                 795                 800 
Glu Glu Arg Ala Ser Leu Ser Arg Asp Lys Arg Leu Ala Leu Val Asp
                805                 810                 815     
Pro Glu Gly Phe Gln Ala Asp Phe Cys Cys Ser Phe Lys Leu Asp Lys
            820                 825                 830         
Ala Ala His Glu Thr Gln Phe Gly Arg Ser Asp Gln His Gly Ser Lys
        835                 840                 845             
Ala Ser Ser Ser Leu Gln Pro Pro Ala Lys Ala Gln Gly Arg Asp Arg
    850                 855                 860                 
Ala Lys Thr Gly Val Thr Glu Pro Met Asn His Asp Gln Phe His Leu
865                 870                 875                 880 
Val Pro Asn His Ile Val Val Ser Ala Glu Gly Asn Ile Ser Lys Lys
                885                 890                 895     
Thr Glu Cys Leu Gly Arg Ala Leu Lys Phe Asp Lys Val Gly Leu Val
            900                 905                 910         
Gln Tyr Gln Ser Thr Ser Glu Glu Lys Ala Ser Arg Arg Glu Pro Leu
        915                 920                 925             
Lys Ala Ser Gln Cys Ser Pro Gly Pro Glu Gly His Arg Lys Thr Ser
    930                 935                 940                 
Ser Arg Ser Asp His Gly Thr Glu Ser Lys Leu Ser Ser Ile Leu Ala
945                 950                 955                 960 
Asp Ser His Leu Glu Met Thr Cys Asn Asn Ser Phe Gln Asp Lys Ser
                965                 970                 975     
Leu Arg Asn Ser Pro Lys Asn Glu Val Leu His Thr Asp Ile Met Lys
            980                 985                 990         
Gly Ser Gly Glu Pro Gln Pro Asp Leu Gln Leu Thr Lys Ser Leu Glu
        995                 1000                1005            
Thr Thr Phe Lys Asn Ile Leu Glu Leu Lys Lys Ala Gly Arg Gln Pro
    1010                1015                1020                
Gln Ser Asp Pro Thr Val Ser Gly Ser Val Glu Leu Asp Phe Pro Asn
1025                1030                1035                1040
Phe Ser Pro Met Ala Ser Gln Glu Asn Cys Leu Glu Lys Phe Ile Pro
                1045                1050                1055    
Asp His Ser Glu Gly Val Val Glu Thr Asp Ser Ile Leu Glu Ala Ala
            1060                1065                1070        
Val Asn Ser Ile Leu Glu Cys
        1075                


<210> 6758
<211> 761
<212> PRT
<213> Homo sapiens

<400> 6758
Met Arg Gln Asp Lys Leu Thr Gly Ser Leu Arg Arg Gly Gly Arg Cys
 1               5                  10                  15      
Leu Lys Arg Gln Gly Gly Gly Val Gly Thr Ile Leu Ser Asn Val Leu
            20                  25                  30          
Lys Lys Arg Ser Cys Ile Ser Arg Thr Ala Pro Arg Leu Leu Cys Thr
        35                  40                  45              
Leu Glu Pro Gly Val Asp Thr Lys Leu Lys Phe Thr Leu Glu Pro Ser
    50                  55                  60                  
Leu Gly Gln Asn Gly Phe Gln Gln Trp Tyr Asp Ala Leu Lys Ala Val
65                  70                  75                  80  
Ala Arg Leu Ser Thr Gly Ile Pro Lys Glu Trp Arg Arg Lys Val Trp
                85                  90                  95      
Leu Thr Leu Ala Asp His Tyr Leu His Ser Ile Ala Ile Asp Trp Asp
            100                 105                 110         
Lys Thr Met Arg Phe Thr Phe Asn Glu Arg Ser Asn Pro Asp Asp Asp
        115                 120                 125             
Ser Met Gly Ile Gln Ile Val Lys Asp Leu His Arg Thr Gly Cys Ser
    130                 135                 140                 
Ser Tyr Cys Gly Gln Glu Ala Glu Gln Asp Arg Val Val Leu Lys Arg
145                 150                 155                 160 
Val Leu Leu Ala Tyr Ala Arg Trp Asn Lys Thr Val Gly Tyr Cys Gln
                165                 170                 175     
Gly Phe Asn Ile Leu Ala Ala Leu Ile Leu Glu Val Met Glu Gly Asn
            180                 185                 190         
Glu Gly Asp Ala Leu Lys Ile Met Ile Tyr Leu Ile Asp Lys Val Leu
        195                 200                 205             
Pro Glu Ser Tyr Phe Val Asn Asn Leu Arg Ala Leu Ser Val Asp Met
    210                 215                 220                 
Ala Val Phe Arg Asp Leu Leu Arg Met Lys Leu Pro Glu Leu Ser Gln
225                 230                 235                 240 
His Leu Asp Thr Leu Gln Arg Thr Ala Asn Lys Glu Ser Gly Gly Gly
                245                 250                 255     
Tyr Glu Pro Pro Leu Thr Asn Val Phe Thr Met Gln Trp Phe Leu Thr
            260                 265                 270         
Leu Phe Ala Thr Cys Leu Pro Asn Gln Thr Val Leu Lys Ile Trp Asp
        275                 280                 285             
Ser Val Phe Phe Glu Gly Ser Glu Ile Ile Leu Arg Val Ser Leu Ala
    290                 295                 300                 
Ile Trp Ala Lys Leu Gly Glu Gln Ile Glu Cys Cys Glu Thr Ala Asp
305                 310                 315                 320 
Glu Phe Tyr Ser Thr Met Gly Arg Leu Thr Gln Glu Met Leu Glu Asn
                325                 330                 335     
Asp Leu Leu Gln Ser His Glu Leu Met Gln Thr Val Tyr Ser Met Ala
            340                 345                 350         
Pro Phe Pro Phe Pro Gln Leu Ala Glu Leu Arg Glu Lys Tyr Thr Tyr
        355                 360                 365             
Asn Ile Thr Pro Phe Pro Ala Thr Val Lys Pro Thr Ser Val Ser Gly
    370                 375                 380                 
Arg His Ser Lys Ala Arg Asp Ser Asp Glu Glu Asn Asp Pro Asp Asp
385                 390                 395                 400 
Glu Asp Ala Val Val Asn Ala Val Gly Cys Leu Gly Pro Phe Ser Gly
                405                 410                 415     
Phe Leu Ala Pro Glu Leu Gln Lys Tyr Gln Lys Gln Ile Lys Glu Pro
            420                 425                 430         
Asn Glu Glu Gln Ser Leu Arg Ser Asn Asn Ile Ala Glu Leu Ser Pro
        435                 440                 445             
Gly Ala Ile Asn Ser Cys Arg Ser Glu Tyr His Ala Ala Phe Asn Ser
    450                 455                 460                 
Met Met Met Glu Arg Met Thr Thr Asp Ile Asn Ala Leu Lys Arg Gln
465                 470                 475                 480 
Tyr Ser Arg Ile Lys Lys Lys Gln Gln Gln Gln Val His Gln Val Tyr
                485                 490                 495     
Ile Arg Ala Asp Lys Gly Pro Val Thr Ser Ile Leu Pro Ser Gln Val
            500                 505                 510         
Asn Ser Ser Pro Val Ile Asn His Leu Leu Leu Gly Lys Lys Met Lys
        515                 520                 525             
Met Thr Asn Arg Ala Ala Lys Asn Ala Val Ile His Ile Pro Gly His
    530                 535                 540                 
Thr Gly Gly Lys Ile Ser Pro Val Pro Tyr Glu Asp Leu Lys Thr Lys
545                 550                 555                 560 
Leu Asn Ser Pro Trp Arg Thr His Ile Arg Val His Lys Lys Asn Met
                565                 570                 575     
Pro Arg Thr Lys Ser His Pro Gly Cys Gly Asp Thr Val Gly Leu Ile
            580                 585                 590         
Asp Glu Gln Asn Glu Ala Ser Lys Thr Asn Gly Leu Gly Ala Ala Glu
        595                 600                 605             
Ala Phe Pro Ser Gly Cys Thr Ala Thr Ala Gly Arg Glu Gly Ser Ser
    610                 615                 620                 
Pro Glu Gly Ser Thr Arg Arg Thr Ile Glu Gly Gln Ser Pro Glu Pro
625                 630                 635                 640 
Val Phe Gly Asp Ala Asp Val Asp Val Ser Ala Val Gln Ala Lys Leu
                645                 650                 655     
Gly Ala Leu Glu Leu Asn Gln Arg Asp Ala Ala Ala Glu Thr Glu Leu
            660                 665                 670         
Arg Val His Pro Pro Cys Gln Arg His Cys Pro Glu Pro Pro Ser Ala
        675                 680                 685             
Pro Glu Glu Asn Lys Ala Thr Ser Lys Ala Pro Gln Gly Ser Asn Ser
    690                 695                 700                 
Lys Thr Pro Ile Phe Ser Pro Phe Pro Ser Val Lys Pro Leu Arg Lys
705                 710                 715                 720 
Ser Ala Thr Ala Arg Asn Leu Gly Leu Tyr Gly Pro Thr Glu Arg Thr
                725                 730                 735     
Pro Thr Val His Phe Pro Gln Met Ser Arg Ser Phe Ser Lys Pro Gly
            740                 745                 750         
Gly Gly Asn Ser Gly Thr Lys Lys Arg
        755                 760     


<210> 6759
<211> 542
<212> PRT
<213> Homo sapiens

<400> 6759
Met Asp Asp Pro Arg Tyr Gly Met Cys Pro Leu Lys Gly Ala Ser Gly
 1               5                  10                  15      
Cys Pro Gly Ala Glu Arg Ser Leu Leu Val Gln Ser Tyr Phe Glu Lys
            20                  25                  30          
Gly Pro Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu
        35                  40                  45              
Trp Gln Cys Leu Asp Ser Ala Gln Gln Gly Leu Tyr Arg Lys Val Met
    50                  55                  60                  
Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Ala Gly Ile Ala Leu Thr
65                  70                  75                  80  
Lys Pro Asp Leu Ile Thr Cys Leu Glu Gln Gly Lys Glu Pro Trp Asn
                85                  90                  95      
Ile Lys Arg His Glu Met Val Ala Lys Pro Pro Val Ile Cys Ser His
            100                 105                 110         
Phe Pro Gln Asp Leu Trp Ala Glu Gln Asp Ile Lys Asp Ser Phe Gln
        115                 120                 125             
Glu Ala Ile Leu Lys Lys Tyr Gly Lys Tyr Gly His Asp Asn Leu Gln
    130                 135                 140                 
Leu Gln Lys Gly Cys Lys Ser Val Asp Glu Cys Lys Val His Lys Glu
145                 150                 155                 160 
His Asp Asn Lys Leu Asn Gln Cys Leu Ile Thr Thr Gln Ser Asn Ile
                165                 170                 175     
Phe Gln Cys Asp Pro Ser Ala Lys Val Phe His Thr Phe Ser Asn Ser
            180                 185                 190         
Asn Arg His Lys Ile Arg His Thr Arg Lys Lys Pro Phe Lys Cys Lys
        195                 200                 205             
Lys Cys Glu Lys Ser Phe Cys Met Leu Leu His Leu Thr Gln His Lys
    210                 215                 220                 
Arg Phe His Ile Thr Glu Asn Ser Tyr Gln Cys Lys Asp Cys Gly Lys
225                 230                 235                 240 
Ala Phe Asn Trp Phe Ser Thr Leu Thr Thr His Arg Arg Ile His Thr
                245                 250                 255     
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg
            260                 265                 270         
Ser Ser His Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro
        275                 280                 285             
Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser His Leu
    290                 295                 300                 
Thr Thr His Lys Arg Ile His Thr Gly Val Lys Pro Tyr Lys Cys Thr
305                 310                 315                 320 
Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser His Leu Thr Thr His Arg
                325                 330                 335     
Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
            340                 345                 350         
Ala Phe Asn Gln Ser Ser Thr Leu Thr Thr His Lys Ile Thr His Ala
        355                 360                 365             
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Tyr Arg
    370                 375                 380                 
Phe Ser Tyr Leu Ile Lys His Lys Thr Ser His Thr Gly Glu Lys Phe
385                 390                 395                 400 
Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Asn Trp Ser Ser Ala Leu
                405                 410                 415     
Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
            420                 425                 430         
Glu Cys Gly Lys Ala Phe Asn Glu Ser Ser Asn Leu Thr Thr His Lys
        435                 440                 445             
Met Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys
    450                 455                 460                 
Ala Phe Asn Arg Ser Ser Gln Leu Thr Ala His Lys Met Ile His Thr
465                 470                 475                 480 
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg
                485                 490                 495     
Ser Ser Thr Leu Thr Lys His Lys Ile Thr His Thr Gly Glu Lys Ser
            500                 505                 510         
Tyr Lys Trp Glu Glu Cys Gly Lys Asp Phe Asn Gln Ser Leu Ser Leu
        515                 520                 525             
Ile Lys Gln Asn Asn Ser Tyr Trp Arg Glu Thr Leu Gln Met
    530                 535                 540         


<210> 6760
<211> 565
<212> PRT
<213> Homo sapiens

<400> 6760
Glu Glu Gly Pro Leu Pro Leu Leu Thr Phe Ala Thr Ala Pro Tyr His
 1               5                  10                  15      
Asp Gln Lys Pro Gly Thr Ser Gly Leu Arg Lys Lys Thr Tyr Tyr Phe
            20                  25                  30          
Glu Glu Lys Pro Cys Tyr Leu Glu Asn Phe Ile Gln Ser Ile Phe Phe
        35                  40                  45              
Ser Ile Asp Leu Lys Asp Arg Gln Gly Ser Ser Leu Val Val Gly Gly
    50                  55                  60                  
Asp Gly Arg Tyr Phe Asn Lys Ser Ala Ile Glu Thr Ile Val Gln Met
65                  70                  75                  80  
Ala Ala Ala Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile
                85                  90                  95      
Leu Ser Thr Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile
            100                 105                 110         
Gly Gly Ile Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly
        115                 120                 125             
Asp Phe Gly Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu
    130                 135                 140                 
Ala Ile Thr Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr
145                 150                 155                 160 
Ala Val Cys Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln
                165                 170                 175     
Gln Phe Asp Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val
            180                 185                 190         
Asp Ser Val Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe
        195                 200                 205             
Ser Ala Leu Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg
    210                 215                 220                 
Ile Asp Ala Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu
225                 230                 235                 240 
Cys Glu Glu Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro
                245                 250                 255     
Leu Glu Asp Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala
            260                 265                 270         
Ala Asp Leu Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala
        275                 280                 285             
Ala Phe Asp Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly
    290                 295                 300                 
Phe Phe Val Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile
305                 310                 315                 320 
Phe Ser Ile Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg
                325                 330                 335     
Ser Met Pro Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys
            340                 345                 350         
Ile Ala Leu Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu
        355                 360                 365             
Met Asp Ala Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr
    370                 375                 380                 
Gly Ser Asp His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala
385                 390                 395                 400 
Trp Leu Ser Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu
                405                 410                 415     
Lys Asp His Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp
            420                 425                 430         
Tyr Glu Glu Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu
        435                 440                 445             
Glu Ala Leu Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala
    450                 455                 460                 
Asn Asp Lys Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser
465                 470                 475                 480 
Asp Pro Val Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile
                485                 490                 495     
Phe Thr Asp Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser
            500                 505                 510         
Ala Gly Ala Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val
        515                 520                 525             
Ala Lys Ile Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser
    530                 535                 540                 
Ile Ala Leu Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala
545                 550                 555                 560 
Pro Thr Val Ile Thr
                565 


<210> 6761
<211> 561
<212> PRT
<213> Homo sapiens

<400> 6761
Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys Pro
 1               5                  10                  15      
Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser Ala
            20                  25                  30          
Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu Pro
        35                  40                  45              
Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg Phe
    50                  55                  60                  
Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala Asn
65                  70                  75                  80  
Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr Pro
                85                  90                  95      
Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile Ile
            100                 105                 110         
Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly Ile
        115                 120                 125             
Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr Asp
    130                 135                 140                 
Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys Pro
145                 150                 155                 160 
Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp Leu
                165                 170                 175     
Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val Glu
            180                 185                 190         
Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu Lys
        195                 200                 205             
Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala Met
    210                 215                 220                 
His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu Leu
225                 230                 235                 240 
Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp Phe
                245                 250                 255     
Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu Val
            260                 265                 270         
Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp Gly
        275                 280                 285             
Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val Asn
    290                 295                 300                 
Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile Pro
305                 310                 315                 320 
Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro Thr
                325                 330                 335     
Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu Tyr
            340                 345                 350         
Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala Ser
        355                 360                 365             
Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp His
    370                 375                 380                 
Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser Ile
385                 390                 395                 400 
Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His Trp
                405                 410                 415     
Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu Val
            420                 425                 430         
Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu Met
        435                 440                 445             
Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys Val
    450                 455                 460                 
Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val Asp
465                 470                 475                 480 
Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp Gly
                485                 490                 495     
Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala Thr
            500                 505                 510         
Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile Asn
        515                 520                 525             
Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu Lys
    530                 535                 540                 
Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val Ile
545                 550                 555                 560 
Thr
    


<210> 6762
<211> 2342
<212> PRT
<213> Homo sapiens

<400> 6762
Met Ile Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln
 1               5                  10                  15      
Cys Phe Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser
            20                  25                  30          
Phe Gln Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu
        35                  40                  45              
Leu Ser Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys
    50                  55                  60                  
Pro Glu Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu
65                  70                  75                  80  
Gln Asp Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu
                85                  90                  95      
Met Glu Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu
            100                 105                 110         
Val Pro Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe
        115                 120                 125             
Leu Lys Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly
    130                 135                 140                 
Asp Ser Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly
145                 150                 155                 160 
Gly Ser Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp
                165                 170                 175     
Arg Val Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro
            180                 185                 190         
Gly Ile Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu
        195                 200                 205             
Gln Ser Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile
    210                 215                 220                 
Ser Pro Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys
225                 230                 235                 240 
Asn Pro Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys
                245                 250                 255     
Phe Thr Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu
            260                 265                 270         
Phe Arg Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys
        275                 280                 285             
Met Gly Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser
    290                 295                 300                 
Ser Lys Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys
305                 310                 315                 320 
Asp Lys Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro
                325                 330                 335     
Ile Ser Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala
            340                 345                 350         
Asn Pro Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr
        355                 360                 365             
Gln Tyr Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe
    370                 375                 380                 
Leu Lys Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro
385                 390                 395                 400 
Thr Pro Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg
                405                 410                 415     
Glu Ser Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg
            420                 425                 430         
Lys Glu Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val
        435                 440                 445             
Glu Lys Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys
    450                 455                 460                 
Asp Lys Pro Val Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu
465                 470                 475                 480 
Val Pro Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu
                485                 490                 495     
Lys Gln Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val
            500                 505                 510         
Lys Lys Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu
        515                 520                 525             
Lys Pro Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys
    530                 535                 540                 
Lys Glu Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys
545                 550                 555                 560 
Glu Ile Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys
                565                 570                 575     
Glu Thr Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys
            580                 585                 590         
Lys Glu Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys
        595                 600                 605             
Leu Pro Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys
    610                 615                 620                 
Lys Pro Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val
625                 630                 635                 640 
Lys Lys Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile
                645                 650                 655     
Lys Val Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala
            660                 665                 670         
Val Gly Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile
        675                 680                 685             
Ala Ala Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met
    690                 695                 700                 
Ser Ser Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu
705                 710                 715                 720 
Glu Val Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu
                725                 730                 735     
Asp Glu Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile
            740                 745                 750         
Gln Lys Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu
        755                 760                 765             
Gly Ile Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu
    770                 775                 780                 
Glu Leu Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe
785                 790                 795                 800 
Glu Asp Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr
                805                 810                 815     
Glu Glu Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly
            820                 825                 830         
Glu Glu His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp
        835                 840                 845             
Glu Glu Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg
    850                 855                 860                 
Glu Ser Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu
865                 870                 875                 880 
Ala Ile Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu
                885                 890                 895     
Glu Asp Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys
            900                 905                 910         
Met Glu Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala Glu
        915                 920                 925             
Ala Gly Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro Thr Lys
    930                 935                 940                 
Gln Leu Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser Ser Ile His
945                 950                 955                 960 
Asp Glu Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala Thr Ala Ser Asp
                965                 970                 975     
Glu Glu Asn Arg Glu Asp Gln Pro Glu Glu Phe Thr Ala Thr Ser Gly
            980                 985                 990         
Tyr Thr Gln Ser Thr Ile Glu Ile Ser Ser Glu Pro Thr Pro Met Asp
        995                 1000                1005            
Glu Met Ser Thr Pro Arg Asp Val Met Ser Asp Glu Thr Asn Asn Glu
    1010                1015                1020                
Glu Thr Glu Ser Pro Ser Gln Glu Phe Val Asn Ile Thr Lys Tyr Glu
1025                1030                1035                1040
Ser Ser Leu Tyr Ser Gln Glu Tyr Ser Lys Pro Ala Asp Val Thr Pro
                1045                1050                1055    
Leu Asn Gly Phe Ser Glu Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys
            1060                1065                1070        
Asp Tyr Asn Ala Ser Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu
        1075                1080                1085            
Glu Asp Lys Phe Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu
    1090                1095                1100                
Val Lys Ala Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val
1105                1110                1115                1120
Ser Ser Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser
                1125                1130                1135    
Pro Pro Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn
            1140                1145                1150        
Phe Ser Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu Val
        1155                1160                1165            
Ala Pro Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu His Cys
    1170                1175                1180                
Ala Ser Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro Ser Gln Ser
1185                1190                1195                1200
Val Thr Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln Ser Pro Thr Asp
                1205                1210                1215    
Glu Lys Ser Ser His Leu Pro Thr Glu Val Ile Glu Lys Pro Pro Ala
            1220                1225                1230        
Val Pro Val Ser Phe Glu Phe Ser Asp Ala Lys Asp Glu Asn Glu Arg
        1235                1240                1245            
Ala Ser Val Ser Pro Met Asp Glu Pro Val Pro Asp Ser Glu Ser Pro
    1250                1255                1260                
Ile Glu Lys Val Leu Ser Pro Leu Arg Ser Pro Pro Leu Ile Gly Ser
1265                1270                1275                1280
Glu Ser Ala Tyr Glu Ser Phe Leu Ser Ala Asp Asp Lys Ala Ser Gly
                1285                1290                1295    
Arg Gly Ala Glu Ser Pro Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser
            1300                1305                1310        
Pro Asp Gln Val Ser Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr
        1315                1320                1325            
Gln Asp Lys Gln Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu
    1330                1335                1340                
Asp Phe Gly Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser
1345                1350                1355                1360
Gln Pro Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro
                1365                1370                1375    
Thr Gln Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys
            1380                1385                1390        
Met Ser Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro Val
        1395                1400                1405            
Asp Glu Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly Val Ala
    1410                1415                1420                
Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro Glu Pro Thr
1425                1430                1435                1440
Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu Val Gly Ser Pro His
                1445                1450                1455    
Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser Val Val Gln Thr Pro
            1460                1465                1470        
Thr Thr Phe Gln Glu Thr Glu Met Ser Pro Ser Lys Glu Glu Cys Pro
        1475                1480                1485            
Arg Pro Met Ser Ile Ser Pro Pro Asp Phe Ser Pro Lys Thr Ala Lys
    1490                1495                1500                
Ser Arg Thr Pro Val Gln Asp His Arg Ser Glu Gln Ser Ser Met Ser
1505                1510                1515                1520
Ile Glu Phe Gly Gln Glu Ser Pro Glu Gln Ser Leu Ala Met Asp Phe
                1525                1530                1535    
Ser Arg Gln Ser Pro Asp His Pro Thr Val Gly Ala Gly Val Leu His
            1540                1545                1550        
Ile Thr Glu Asn Gly Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met
        1555                1560                1565            
Gln Asp Ser Ser Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser
    1570                1575                1580                
Tyr Thr Gln Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val
1585                1590                1595                1600
Glu Ala Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala
                1605                1610                1615    
Ser Pro Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp
            1620                1625                1630        
Met Ser Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu Glu
        1635                1640                1645            
Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr Pro Arg
    1650                1655                1660                
Glu Ser Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser Thr Ser Ala
1665                1670                1675                1680
Val Lys Glu Lys Thr Ala Thr Cys His Ser Ser Ser Ser Pro Pro Ile
                1685                1690                1695    
Asp Ala Ala Ser Ala Glu Pro Tyr Gly Phe Arg Ala Ser Val Leu Phe
            1700                1705                1710        
Asp Thr Met Gln His His Leu Ala Leu Asn Arg Asp Leu Ser Thr Pro
        1715                1720                1725            
Gly Leu Glu Lys Asp Ser Gly Gly Lys Thr Pro Gly Asp Phe Ser Tyr
    1730                1735                1740                
Ala Tyr Gln Lys Pro Glu Glu Thr Thr Arg Ser Pro Asp Glu Glu Asp
1745                1750                1755                1760
Tyr Asp Tyr Glu Ser Tyr Glu Lys Thr Thr Arg Thr Ser Asp Val Gly
                1765                1770                1775    
Gly Tyr Tyr Tyr Glu Lys Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp
            1780                1785                1790        
Ser Gly Tyr Ser Tyr Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu
        1795                1800                1805            
Asp Gly Asp Tyr Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro
    1810                1815                1820                
Glu Glu Gly Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro
1825                1830                1835                1840
Pro Glu Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg
                1845                1850                1855    
Leu Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly
            1860                1865                1870        
His Thr Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys Ile
        1875                1880                1885            
Thr Ser Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser Thr Lys
    1890                1895                1900                
Thr Thr Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu Thr Ala Glu
1905                1910                1915                1920
Lys Ile Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser Tyr Glu Thr Ser
                1925                1930                1935    
Asp Leu Cys Tyr Thr Ala Glu Lys Lys Ser Pro Ser Glu Ala Arg Gln
            1940                1945                1950        
Asp Val Asp Leu Cys Leu Val Ser Ser Cys Glu Tyr Lys His Pro Lys
        1955                1960                1965            
Thr Glu Leu Ser Pro Ser Phe Ile Asn Pro Asn Pro Leu Glu Trp Phe
    1970                1975                1980                
Ala Ser Glu Glu Pro Thr Glu Glu Ser Glu Lys Pro Leu Thr Gln Ser
1985                1990                1995                2000
Gly Gly Ala Pro Pro Pro Pro Gly Gly Lys Gln Gln Gly Arg Gln Cys
                2005                2010                2015    
Asp Glu Thr Pro Pro Thr Ser Val Ser Glu Ser Ala Pro Ser Gln Thr
            2020                2025                2030        
Asp Ser Asp Val Pro Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala
        2035                2040                2045            
Asp Ala Asn Ile Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp
    2050                2055                2060                
Lys Thr Val Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln
2065                2070                2075                2080
Asp Arg Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro
                2085                2090                2095    
Glu Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp
            2100                2105                2110        
Leu Lys Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys Ser
        2115                2120                2125            
Ser Ser Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu Ala Ala
    2130                2135                2140                
Ser Pro Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys Val Ser Arg
2145                2150                2155                2160
Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu Lys Ala Ala Lys Pro
                2165                2170                2175    
Thr Thr Thr Pro Glu Val Lys Ala Ala Arg Gly Glu Glu Lys Asp Lys
            2180                2185                2190        
Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala Ser Lys Ser Ala Lys Thr
        2195                2200                2205            
Ala Thr Ala Gly Pro Gly Thr Thr Lys Thr Thr Lys Ser Ser Ala Val
    2210                2215                2220                
Pro Pro Gly Leu Pro Val Tyr Leu Asp Leu Cys Tyr Ile Pro Asn His
2225                2230                2235                2240
Ser Asn Ser Lys Asn Val Asp Val Glu Phe Phe Lys Arg Val Arg Ser
                2245                2250                2255    
Ser Tyr Tyr Val Val Ser Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser
            2260                2265                2270        
Arg Ala Val Leu Asp Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser
        2275                2280                2285            
Asn Met Gln Val Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg
    2290                2295                2300                
Glu Trp Tyr Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met
2305                2310                2315                2320
Val Leu Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro
                2325                2330                2335    
Ala Cys Lys Ile Glu Leu
            2340        


<210> 6763
<211> 2468
<212> PRT
<213> Homo sapiens

<400> 6763
Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser
 1               5                  10                  15      
Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe
            20                  25                  30          
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr
        35                  40                  45              
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg
    50                  55                  60                  
Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys
65                  70                  75                  80  
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly
                85                  90                  95      
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu
            100                 105                 110         
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile
        115                 120                 125             
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe
    130                 135                 140                 
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln
145                 150                 155                 160 
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser
                165                 170                 175     
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu
            180                 185                 190         
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp
        195                 200                 205             
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu
    210                 215                 220                 
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro
225                 230                 235                 240 
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys
                245                 250                 255     
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser
            260                 265                 270         
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser
        275                 280                 285             
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val
    290                 295                 300                 
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile
305                 310                 315                 320 
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser
                325                 330                 335     
Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro
            340                 345                 350         
Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro
        355                 360                 365             
Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr
    370                 375                 380                 
Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg
385                 390                 395                 400 
Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly
                405                 410                 415     
Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys
            420                 425                 430         
Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys
        435                 440                 445             
Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser
    450                 455                 460                 
Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro
465                 470                 475                 480 
Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr
                485                 490                 495     
Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys
            500                 505                 510         
Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro
        515                 520                 525             
Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser
    530                 535                 540                 
Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu
545                 550                 555                 560 
Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys
                565                 570                 575     
Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys
            580                 585                 590         
Pro Val Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro
        595                 600                 605             
Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln
    610                 615                 620                 
Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys
625                 630                 635                 640 
Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro
                645                 650                 655     
Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu
            660                 665                 670         
Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile
        675                 680                 685             
Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr
    690                 695                 700                 
Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu
705                 710                 715                 720 
Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro
                725                 730                 735     
Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro
            740                 745                 750         
Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys
        755                 760                 765             
Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val
    770                 775                 780                 
Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly
785                 790                 795                 800 
Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala
                805                 810                 815     
Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser
            820                 825                 830         
Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val
        835                 840                 845             
Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu
    850                 855                 860                 
Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys
865                 870                 875                 880 
Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile
                885                 890                 895     
Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu
            900                 905                 910         
Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp
        915                 920                 925             
Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu
    930                 935                 940                 
Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu
945                 950                 955                 960 
His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu
                965                 970                 975     
Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser
            980                 985                 990         
Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile
        995                 1000                1005            
Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu Asp
    1010                1015                1020                
Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys Met Glu
1025                1030                1035                1040
Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala Glu Ala Gly
                1045                1050                1055    
Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro Thr Lys Gln Leu
            1060                1065                1070        
Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser Ser Ile His Asp Glu
        1075                1080                1085            
Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala Thr Ala Ser Asp Glu Glu
    1090                1095                1100                
Asn Arg Glu Asp Gln Pro Glu Glu Phe Thr Ala Thr Ser Gly Tyr Thr
1105                1110                1115                1120
Gln Ser Thr Ile Glu Ile Ser Ser Glu Pro Thr Pro Met Asp Glu Met
                1125                1130                1135    
Ser Thr Pro Arg Asp Val Met Ser Asp Glu Thr Asn Asn Glu Glu Thr
            1140                1145                1150        
Glu Ser Pro Ser Gln Glu Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser
        1155                1160                1165            
Leu Tyr Ser Gln Glu Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn
    1170                1175                1180                
Gly Phe Ser Glu Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr
1185                1190                1195                1200
Asn Ala Ser Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp
                1205                1210                1215    
Lys Phe Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys
            1220                1225                1230        
Ala Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser
        1235                1240                1245            
Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro Pro
    1250                1255                1260                
Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn Phe Ser
1265                1270                1275                1280
Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu Val Ala Pro
                1285                1290                1295    
Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu His Cys Ala Ser
            1300                1305                1310        
Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro Ser Gln Ser Val Thr
        1315                1320                1325            
Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln Ser Pro Thr Asp Glu Lys
    1330                1335                1340                
Ser Ser His Leu Pro Thr Glu Val Ile Glu Lys Pro Pro Ala Val Pro
1345                1350                1355                1360
Val Ser Phe Glu Phe Ser Asp Ala Lys Asp Glu Asn Glu Arg Ala Ser
                1365                1370                1375    
Val Ser Pro Met Asp Glu Pro Val Pro Asp Ser Glu Ser Pro Ile Glu
            1380                1385                1390        
Lys Val Leu Ser Pro Leu Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser
        1395                1400                1405            
Ala Tyr Glu Ser Phe Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly
    1410                1415                1420                
Ala Glu Ser Pro Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp
1425                1430                1435                1440
Gln Val Ser Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp
                1445                1450                1455    
Lys Gln Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe
            1460                1465                1470        
Gly Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro
        1475                1480                1485            
Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr Gln
    1490                1495                1500                
Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys Met Ser
1505                1510                1515                1520
Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro Val Asp Glu
                1525                1530                1535    
Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly Val Ala Ser Val
            1540                1545                1550        
Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro Glu Pro Thr Thr Asp
        1555                1560                1565            
Asp Val Ser Pro Ser Leu His Ala Glu Val Gly Ser Pro His Ser Thr
    1570                1575                1580                
Glu Val Asp Asp Ser Leu Ser Val Ser Val Val Gln Thr Pro Thr Thr
1585                1590                1595                1600
Phe Gln Glu Thr Glu Met Ser Pro Ser Lys Glu Glu Cys Pro Arg Pro
                1605                1610                1615    
Met Ser Ile Ser Pro Pro Asp Phe Ser Pro Lys Thr Ala Lys Ser Arg
            1620                1625                1630        
Thr Pro Val Gln Asp His Arg Ser Glu Gln Ser Ser Met Ser Ile Glu
        1635                1640                1645            
Phe Gly Gln Glu Ser Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg
    1650                1655                1660                
Gln Ser Pro Asp His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr
1665                1670                1675                1680
Glu Asn Gly Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp
                1685                1690                1695    
Ser Ser Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr
            1700                1705                1710        
Gln Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala
        1715                1720                1725            
Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser Pro
    1730                1735                1740                
Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp Met Ser
1745                1750                1755                1760
Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu Glu Gly Glu
                1765                1770                1775    
Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr Pro Arg Glu Ser
            1780                1785                1790        
Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser Thr Ser Ala Val Lys
        1795                1800                1805            
Glu Lys Thr Ala Thr Cys His Ser Ser Ser Ser Pro Pro Ile Asp Ala
    1810                1815                1820                
Ala Ser Ala Glu Pro Tyr Gly Phe Arg Ala Ser Val Leu Phe Asp Thr
1825                1830                1835                1840
Met Gln His His Leu Ala Leu Asn Arg Asp Leu Ser Thr Pro Gly Leu
                1845                1850                1855    
Glu Lys Asp Ser Gly Gly Lys Thr Pro Gly Asp Phe Ser Tyr Ala Tyr
            1860                1865                1870        
Gln Lys Pro Glu Glu Thr Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp
        1875                1880                1885            
Tyr Glu Ser Tyr Glu Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr
    1890                1895                1900                
Tyr Tyr Glu Lys Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly
1905                1910                1915                1920
Tyr Ser Tyr Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly
                1925                1930                1935    
Asp Tyr Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu
            1940                1945                1950        
Gly Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu
        1955                1960                1965            
Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu Leu
    1970                1975                1980                
Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly His Thr
1985                1990                1995                2000
Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys Ile Thr Ser
                2005                2010                2015    
Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser Thr Lys Thr Thr
            2020                2025                2030        
Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu Thr Ala Glu Lys Ile
        2035                2040                2045            
Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser Tyr Glu Thr Ser Asp Leu
    2050                2055                2060                
Cys Tyr Thr Ala Glu Lys Lys Ser Pro Ser Glu Ala Arg Gln Asp Val
2065                2070                2075                2080
Asp Leu Cys Leu Val Ser Ser Cys Glu Tyr Lys His Pro Lys Thr Glu
                2085                2090                2095    
Leu Ser Pro Ser Phe Ile Asn Pro Asn Pro Leu Glu Trp Phe Ala Ser
            2100                2105                2110        
Glu Glu Pro Thr Glu Glu Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly
        2115                2120                2125            
Ala Pro Pro Pro Pro Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu
    2130                2135                2140                
Thr Pro Pro Thr Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser
2145                2150                2155                2160
Asp Val Pro Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala
                2165                2170                2175    
Asn Ile Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr
            2180                2185                2190        
Val Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg
        2195                2200                2205            
Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu Ala
    2210                2215                2220                
Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp Leu Lys
2225                2230                2235                2240
Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys Ser Ser Ser
                2245                2250                2255    
Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu Ala Ala Ser Pro
            2260                2265                2270        
Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys Val Ser Arg Val Ala
        2275                2280                2285            
Ser Pro Lys Lys Lys Glu Ser Val Glu Lys Ala Ala Lys Pro Thr Thr
    2290                2295                2300                
Thr Pro Glu Val Lys Ala Ala Arg Gly Glu Glu Lys Asp Lys Glu Thr
2305                2310                2315                2320
Lys Asn Ala Ala Asn Ala Ser Ala Ser Lys Ser Ala Lys Thr Ala Thr
                2325                2330                2335    
Ala Gly Pro Gly Thr Thr Lys Thr Thr Lys Ser Ser Ala Val Pro Pro
            2340                2345                2350        
Gly Leu Pro Val Tyr Leu Asp Leu Cys Tyr Ile Pro Asn His Ser Asn
        2355                2360                2365            
Ser Lys Asn Val Asp Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr
    2370                2375                2380                
Tyr Val Val Ser Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala
2385                2390                2395                2400
Val Leu Asp Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met
                2405                2410                2415    
Gln Val Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp
            2420                2425                2430        
Tyr Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu
        2435                2440                2445            
Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala Cys
    2450                2455                2460                
Lys Ile Glu Leu
2465            


<210> 6764
<211> 172
<212> PRT
<213> Homo sapiens

<400> 6764
Met Lys Asp Tyr Ser Lys Leu Gly Val His Asp Met Asn Asp Arg Lys
 1               5                  10                  15      
Arg Leu Phe Gln Leu Ile Lys Ile Ile Lys Ile Met Gln Glu Glu Asp
            20                  25                  30          
Lys Ala Val Ser Ile Pro Glu Arg His Leu Gln Thr Ser Ser Leu Arg
        35                  40                  45              
Ile Lys Ser Gln Glu Leu Arg Ser Gly Pro Arg Arg Gln Leu Asn Phe
    50                  55                  60                  
Asp Ser Pro Ala Asp Asn Lys Asp Arg Asn Ala Ser Asn Asp Gly Phe
65                  70                  75                  80  
Glu Met Cys Ser Leu Ser Asp Phe Ser Ala Asn Glu Gln Lys Ser Thr
                85                  90                  95      
Tyr Leu Lys Val Leu Glu His Met Leu Pro Asp Asp Ser Gln Tyr His
            100                 105                 110         
Thr Lys Thr Gly Ile Leu Asn Ala Thr Ala Gly Asp Ser Tyr Val Gln
        115                 120                 125             
Thr Glu Ile Ser Thr Ser Leu Phe Ser Pro Asn Tyr Leu Ser Ala Ile
    130                 135                 140                 
Leu Gly Asp Cys Asp Ile Pro Ile Ile Gln Arg Ile Ser His Val Ser
145                 150                 155                 160 
Gly Tyr Asn Tyr Gly Ile Pro His Ser Cys Ile Arg
                165                 170         


<210> 6765
<211> 971
<212> PRT
<213> Homo sapiens

<400> 6765
Met Ser Asn Val Ser Glu Glu Arg Arg Lys Arg Gln Gln Asn Ile Lys
 1               5                  10                  15      
Glu Gly Leu Gln Phe Ile Gln Ser Pro Leu Ser Tyr Pro Gly Thr Gln
            20                  25                  30          
Glu Gln Tyr Ala Val Tyr Leu Arg Ala Leu Val Arg Asn Leu Phe Asn
        35                  40                  45              
Glu Gly Asn Asp Val Tyr Arg Glu His Asp Trp Asn Asn Ser Ile Ser
    50                  55                  60                  
Gln Tyr Thr Glu Ala Leu Asn Ile Ala Asp Tyr Ala Lys Ser Glu Glu
65                  70                  75                  80  
Ile Leu Ile Pro Lys Glu Ile Ile Glu Lys Leu Tyr Ile Asn Arg Ile
                85                  90                  95      
Ala Cys Tyr Ser Asn Met Gly Phe His Asp Lys Val Leu Glu Asp Cys
            100                 105                 110         
Asn Ile Val Leu Ser Leu Asn Ala Ser Asn Cys Lys Ala Leu Tyr Arg
        115                 120                 125             
Lys Ser Lys Ala Leu Ser Asp Leu Gly Arg Tyr Lys Lys Ala Tyr Asp
    130                 135                 140                 
Ala Val Ala Lys Cys Ser Leu Ala Val Pro Gln Asp Glu His Val Ile
145                 150                 155                 160 
Lys Leu Thr Gln Glu Leu Ala Gln Lys Leu Gly Phe Lys Ile Arg Lys
                165                 170                 175     
Ala Tyr Val Arg Ala Glu Leu Ser Leu Lys Ser Val Pro Gly Asp Gly
            180                 185                 190         
Ala Thr Lys Ala Leu Asn His Ser Val Glu Asp Ile Glu Pro Asp Leu
        195                 200                 205             
Leu Thr Pro Arg Gln Glu Ala Val Pro Val Val Ser Leu Pro Ala Pro
    210                 215                 220                 
Ser Phe Ser His Glu Val Gly Ser Glu Leu Ala Ser Val Pro Val Met
225                 230                 235                 240 
Pro Leu Thr Ser Ile Leu Pro Leu Gln Val Glu Glu Ser Ala Leu Pro
                245                 250                 255     
Ser Ala Val Leu Ala Asn Gly Gly Lys Met Pro Phe Thr Met Pro Glu
            260                 265                 270         
Ala Phe Leu Asp Asp Gly Asp Met Val Leu Gly Asp Glu Leu Asp Asp
        275                 280                 285             
Leu Leu Asp Ser Ala Pro Glu Thr Asn Glu Thr Val Met Pro Ser Ala
    290                 295                 300                 
Leu Val Arg Gly Pro Leu Gln Thr Ala Ser Val Ser Pro Ser Met Pro
305                 310                 315                 320 
Phe Ser Ala Ser Leu Leu Gly Thr Leu Pro Ile Gly Ala Arg Tyr Ala
                325                 330                 335     
Pro Pro Pro Ser Phe Ser Glu Phe Tyr Pro Pro Leu Thr Ser Ser Leu
            340                 345                 350         
Glu Asp Phe Cys Ser Ser Leu Asn Ser Phe Ser Met Ser Glu Ser Lys
        355                 360                 365             
Arg Asp Leu Ser Thr Ser Thr Ser Arg Glu Gly Thr Pro Leu Asn Asn
    370                 375                 380                 
Ser Asn Ser Ser Leu Leu Leu Met Asn Gly Pro Gly Ser Leu Phe Ala
385                 390                 395                 400 
Ser Glu Asn Phe Leu Gly Ile Ser Ser Gln Pro Arg Asn Asp Phe Gly
                405                 410                 415     
Asn Phe Phe Gly Ser Ala Val Thr Lys Pro Ser Ser Ser Val Thr Pro
            420                 425                 430         
Arg His Pro Leu Glu Gly Thr His Glu Leu Arg Gln Ala Cys Gln Ile
        435                 440                 445             
Cys Phe Val Lys Ser Gly Pro Lys Leu Met Asp Phe Thr Tyr His Ala
    450                 455                 460                 
Asn Ile Asp His Lys Cys Lys Lys Asp Ile Leu Ile Gly Arg Ile Lys
465                 470                 475                 480 
Asn Val Glu Asp Lys Ser Trp Lys Lys Ile Arg Pro Arg Pro Thr Lys
                485                 490                 495     
Thr Asn Tyr Glu Gly Pro Tyr Tyr Ile Cys Lys Asp Val Ala Ala Glu
            500                 505                 510         
Glu Glu Cys Arg Tyr Ser Gly His Cys Thr Phe Ala Tyr Cys Gln Glu
        515                 520                 525             
Glu Ile Asp Val Trp Thr Leu Glu Arg Lys Gly Ala Phe Ser Arg Glu
    530                 535                 540                 
Ala Phe Phe Gly Gly Asn Gly Lys Ile Asn Leu Thr Val Phe Lys Leu
545                 550                 555                 560 
Leu Gln Glu His Leu Gly Glu Phe Ile Phe Leu Cys Glu Lys Cys Phe
                565                 570                 575     
Asp His Lys Pro Arg Met Ile Ser Lys Arg Asn Lys Asp Asn Ser Thr
            580                 585                 590         
Ala Cys Ser His Pro Val Thr Lys His Glu Phe Glu Asp Asn Lys Cys
        595                 600                 605             
Leu Val His Ile Leu Arg Glu Thr Thr Val Lys Tyr Ser Lys Ile Arg
    610                 615                 620                 
Ser Phe His Gly Gln Cys Gln Leu Asp Leu Cys Arg His Glu Val Arg
625                 630                 635                 640 
Tyr Gly Cys Leu Arg Glu Asp Glu Cys Phe Tyr Ala His Ser Leu Val
                645                 650                 655     
Glu Leu Lys Val Trp Ile Met Gln Asn Glu Thr Gly Ile Ser His Asp
            660                 665                 670         
Ala Ile Ala Gln Glu Ser Lys Arg Tyr Trp Gln Asn Leu Glu Ala Asn
        675                 680                 685             
Val Pro Gly Ala Gln Val Leu Gly Asn Gln Ile Met Pro Gly Phe Leu
    690                 695                 700                 
Asn Met Lys Ile Lys Phe Val Cys Ala Gln Cys Leu Arg Asn Gly Gln
705                 710                 715                 720 
Val Ile Glu Pro Asp Lys Asn Arg Lys Tyr Cys Ser Ala Lys Ala Arg
                725                 730                 735     
His Ser Trp Thr Lys Asp Arg Arg Ala Met Arg Val Met Ser Ile Glu
            740                 745                 750         
Arg Lys Lys Trp Met Asn Ile Arg Pro Leu Pro Thr Lys Lys Gln Met
        755                 760                 765             
Pro Leu Gln Phe Asp Leu Cys Asn His Ile Ala Ser Gly Lys Lys Cys
    770                 775                 780                 
Gln Tyr Val Gly Asn Cys Ser Phe Ala His Ser Pro Glu Glu Arg Glu
785                 790                 795                 800 
Val Trp Thr Tyr Met Lys Glu Asn Gly Ile Gln Asp Met Glu Gln Phe
                805                 810                 815     
Tyr Glu Leu Trp Leu Lys Ser Gln Lys Asn Glu Lys Ser Glu Asp Ile
            820                 825                 830         
Ala Ser Gln Ser Asn Lys Glu Asn Gly Lys Gln Ile His Met Pro Thr
        835                 840                 845             
Asp Tyr Ala Glu Val Thr Val Asp Phe His Cys Trp Met Cys Gly Lys
    850                 855                 860                 
Asn Cys Asn Ser Glu Lys Gln Trp Gln Gly His Ile Ser Ser Glu Lys
865                 870                 875                 880 
His Lys Glu Lys Val Phe His Thr Glu Asp Asp Gln Tyr Cys Trp Gln
                885                 890                 895     
His Arg Phe Pro Thr Gly Tyr Phe Ser Ile Cys Asp Arg Tyr Met Asn
            900                 905                 910         
Gly Thr Cys Pro Glu Gly Asn Ser Cys Lys Phe Ala His Gly Asn Ala
        915                 920                 925             
Glu Leu His Glu Trp Glu Glu Arg Arg Asp Ala Leu Lys Met Lys Leu
    930                 935                 940                 
Asn Lys Ala Arg Lys Asp His Leu Ile Gly Pro Asn Asp Asn Asp Phe
945                 950                 955                 960 
Gly Lys Tyr Ser Phe Leu Phe Lys Asp Leu Asn
                965                 970     


<210> 6766
<211> 673
<212> PRT
<213> Homo sapiens

<400> 6766
Met Arg Ser Ile Arg Ser Phe Ala Asn Asp Asp Arg His Val Met Val
 1               5                  10                  15      
Lys His Ser Thr Ile Tyr Pro Ser Pro Glu Glu Leu Glu Ala Val Gln
            20                  25                  30          
Asn Met Val Ser Thr Val Glu Cys Ala Leu Lys His Val Ser Asp Trp
        35                  40                  45              
Leu Asp Glu Thr Asn Lys Gly Thr Lys Thr Glu Gly Glu Thr Glu Val
    50                  55                  60                  
Lys Lys Asp Glu Ala Gly Glu Asn Tyr Ser Lys Asp Gln Gly Gly Arg
65                  70                  75                  80  
Thr Leu Cys Gly Val Met Arg Ile Gly Leu Val Ala Lys Gly Leu Leu
                85                  90                  95      
Ile Lys Asp Asp Met Asp Leu Glu Leu Val Leu Met Cys Lys Asp Lys
            100                 105                 110         
Pro Thr Glu Thr Leu Leu Asn Thr Val Lys Asp Asn Leu Pro Ile Gln
        115                 120                 125             
Ile Gln Lys Leu Thr Glu Glu Lys Tyr Gln Val Glu Gln Cys Val Asn
    130                 135                 140                 
Glu Ala Ser Ile Ile Ile Arg Asn Thr Lys Glu Pro Thr Leu Thr Leu
145                 150                 155                 160 
Lys Val Ile Leu Thr Ser Pro Leu Ile Arg Asp Glu Ile Gly Arg Arg
                165                 170                 175     
Lys Asp Gly Glu Asn Val Ser Met Lys Asp Pro Pro Asp Leu Leu Asp
            180                 185                 190         
Arg Gln Lys Cys Leu Asn Ala Leu Ala Ser Leu Arg His Ala Lys Trp
        195                 200                 205             
Phe Gln Ala Arg Ala Asn Gly Leu Lys Ser Cys Val Ile Val Leu Arg
    210                 215                 220                 
Ile Leu Arg Asp Leu Cys Asn Arg Val Pro Thr Trp Ala Pro Leu Lys
225                 230                 235                 240 
Gly Trp Pro Leu Glu Leu Ile Cys Glu Lys Ser Ile Gly Thr Cys Asn
                245                 250                 255     
Arg Pro Leu Gly Ala Gly Glu Ala Leu Arg Arg Val Met Glu Cys Leu
            260                 265                 270         
Ala Ser Gly Ile Leu Leu Pro Gly Gly Pro Gly Leu His Asp Pro Cys
        275                 280                 285             
Glu Arg Asp Pro Thr Asp Ala Leu Ser Tyr Met Thr Ile Gln Gln Lys
    290                 295                 300                 
Glu Asp Ile Thr His Ser Ala Gln His Ala Leu Arg Leu Ser Ala Phe
305                 310                 315                 320 
Gly Gln Ile Tyr Lys Val Leu Glu Met Asp Pro Leu Pro Ser Ser Lys
                325                 330                 335     
Pro Phe Gln Lys Tyr Ser Trp Ser Val Thr Asp Lys Glu Gly Ala Gly
            340                 345                 350         
Ser Ser Ala Leu Lys Arg Pro Phe Glu Asp Gly Leu Gly Asp Asp Lys
        355                 360                 365             
Asp Pro Asn Lys Lys Met Lys Arg Asn Leu Arg Lys Ile Leu Asp Ser
    370                 375                 380                 
Lys Ala Ile Asp Leu Met Asn Ala Leu Met Arg Leu Asn Gln Ile Arg
385                 390                 395                 400 
Pro Gly Leu Gln Tyr Lys Leu Leu Ser Gln Ser Gly Pro Val His Ala
                405                 410                 415     
Pro Val Phe Thr Met Ser Val Asp Val Asp Gly Thr Thr Tyr Glu Ala
            420                 425                 430         
Ser Gly Pro Ser Lys Lys Thr Ala Lys Leu His Val Ala Val Lys Val
        435                 440                 445             
Leu Gln Ala Met Gly Tyr Pro Thr Gly Phe Asp Ala Asp Ile Glu Cys
    450                 455                 460                 
Met Ser Ser Asp Glu Lys Ser Asp Asn Glu Ser Lys Asn Glu Thr Val
465                 470                 475                 480 
Ser Ser Asn Ser Ser Asn Asn Thr Gly Asn Ser Thr Thr Glu Thr Ser
                485                 490                 495     
Ser Thr Leu Glu Val Arg Thr Gln Gly Pro Ile Leu Thr Ala Ser Gly
            500                 505                 510         
Lys Asn Pro Val Met Glu Leu Asn Glu Lys Arg Arg Gly Leu Lys Tyr
        515                 520                 525             
Glu Leu Ile Ser Glu Thr Gly Gly Ser His Asp Lys Arg Phe Val Met
    530                 535                 540                 
Glu Val Glu Val Asp Gly Gln Lys Phe Arg Gly Ala Gly Pro Asn Lys
545                 550                 555                 560 
Lys Val Ala Lys Ala Ser Ala Ala Leu Ala Ala Leu Glu Lys Leu Phe
                565                 570                 575     
Ser Gly Pro Asn Ala Ala Asn Asn Lys Lys Lys Lys Ile Ile Pro Gln
            580                 585                 590         
Ala Lys Gly Val Val Asn Thr Ala Val Ser Ala Ala Val Gln Ala Val
        595                 600                 605             
Arg Gly Arg Gly Arg Gly Thr Leu Thr Arg Gly Ala Phe Val Gly Ala
    610                 615                 620                 
Thr Ala Ala Pro Gly Tyr Ile Ala Pro Gly Tyr Gly Thr Pro Tyr Gly
625                 630                 635                 640 
Tyr Ser Thr Ala Ala Pro Ala Tyr Gly Leu Pro Lys Arg Met Val Leu
                645                 650                 655     
Leu Pro Val Met Lys Phe Pro Thr Tyr Pro Val Pro His Tyr Ser Phe
            660                 665                 670         
Phe
    


<210> 6767
<211> 446
<212> PRT
<213> Homo sapiens

<400> 6767
Met Lys Asn Ala Leu Ile Pro Arg Ile Lys Asn Ala Cys Leu Gln Thr
 1               5                  10                  15      
Ser Ser Leu Ala Val Arg Val Asn Ser Leu Val Cys Leu Gly Lys Ile
            20                  25                  30          
Leu Glu Tyr Leu Asp Lys Trp Phe Val Leu Asp Asp Ile Leu Pro Phe
        35                  40                  45              
Leu Gln Gln Ile Pro Ser Lys Glu Pro Ala Val Leu Met Gly Ile Leu
    50                  55                  60                  
Gly Ile Tyr Lys Cys Thr Phe Thr His Lys Lys Leu Gly Ile Thr Lys
65                  70                  75                  80  
Glu Gln Leu Ala Gly Lys Val Leu Pro His Leu Ile Pro Leu Ser Ile
                85                  90                  95      
Glu Asn Asn Leu Asn Leu Asn Gln Phe Asn Ser Phe Ile Ser Val Ile
            100                 105                 110         
Lys Glu Met Leu Asn Arg Leu Glu Ser Glu His Lys Thr Lys Leu Glu
        115                 120                 125             
Gln Leu His Ile Met Gln Glu Gln Gln Lys Ser Leu Asp Ile Gly Asn
    130                 135                 140                 
Gln Met Asn Val Ser Glu Glu Met Lys Val Thr Asn Ile Gly Asn Gln
145                 150                 155                 160 
Gln Ile Asp Lys Val Phe Asn Asn Ile Gly Ala Asp Leu Leu Thr Gly
                165                 170                 175     
Ser Glu Ser Glu Asn Lys Glu Asp Gly Leu Gln Asn Lys His Lys Arg
            180                 185                 190         
Ala Ser Leu Thr Leu Glu Glu Lys Gln Lys Leu Ala Lys Glu Gln Glu
        195                 200                 205             
Gln Ala Gln Lys Leu Lys Ser Gln Gln Pro Leu Lys Pro Gln Val His
    210                 215                 220                 
Thr Pro Val Ala Thr Val Lys Gln Thr Lys Asp Leu Thr Asp Thr Leu
225                 230                 235                 240 
Met Asp Asn Met Ser Ser Leu Thr Ser Leu Ser Val Ser Thr Pro Lys
                245                 250                 255     
Ser Ser Ala Ser Ser Thr Phe Ala Ser Val Pro Ser Met Gly Ile Gly
            260                 265                 270         
Met Met Phe Ser Thr Pro Thr Asp Asn Thr Lys Arg Asn Leu Thr Asn
        275                 280                 285             
Gly Leu Asn Ala Asn Met Gly Phe Gln Thr Ser Gly Phe Asn Met Pro
    290                 295                 300                 
Val Asn Thr Asn Gln Asn Phe Tyr Ser Ser Pro Ser Thr Val Gly Val
305                 310                 315                 320 
Thr Lys Met Thr Leu Gly Thr Pro Pro Thr Leu Pro Asn Phe Asn Ala
                325                 330                 335     
Leu Ser Val Pro Pro Ala Gly Ala Lys Gln Thr Gln Gln Arg Pro Thr
            340                 345                 350         
Asp Met Ser Ala Leu Asn Asn Leu Phe Gly Pro Gln Lys Pro Lys Val
        355                 360                 365             
Ser Met Asn Gln Leu Ser Gln Gln Lys Pro Asn Gln Trp Leu Asn Gln
    370                 375                 380                 
Phe Val Pro Pro Gln Gly Ser Pro Thr Met Gly Ser Ser Val Met Gly
385                 390                 395                 400 
Thr Gln Met Asn Val Ile Gly Gln Ser Ala Phe Gly Met Gln Gly Asn
                405                 410                 415     
Pro Phe Phe Asn Pro Gln Asn Phe Ala Gln Pro Pro Thr Thr Met Thr
            420                 425                 430         
Asn Ser Ser Ser Ala Ser Asn Asp Leu Lys Asp Leu Phe Gly
        435                 440                 445     


<210> 6768
<211> 796
<212> PRT
<213> Homo sapiens

<400> 6768
Ser Leu Met Ser Gly Asp Ile Gly Asp Tyr Lys Leu Tyr Asp Val Glu
 1               5                  10                  15      
Thr Lys Tyr Gly Leu Leu Gln Val Ser Glu Gly Leu Ser Phe Leu His
            20                  25                  30          
Ser Ser Val Lys Met Val His Gly Asn Ile Thr Pro Glu Asn Ile Ile
        35                  40                  45              
Leu Asn Lys Ser Gly Ala Trp Lys Ile Met Gly Phe Asp Phe Cys Val
    50                  55                  60                  
Ser Ser Thr Asn Pro Ser Glu Gln Glu Pro Lys Phe Pro Cys Lys Glu
65                  70                  75                  80  
Trp Asp Pro Asn Leu Pro Ser Leu Cys Leu Pro Asn Pro Glu Tyr Leu
                85                  90                  95      
Ala Pro Glu Tyr Ile Leu Ser Val Ser Cys Glu Thr Ala Ser Asp Met
            100                 105                 110         
Tyr Ser Leu Gly Thr Val Met Tyr Ala Val Phe Asn Lys Gly Lys Pro
        115                 120                 125             
Ile Phe Glu Val Asn Lys Gln Asp Ile Tyr Lys Ser Phe Ser Arg Gln
    130                 135                 140                 
Leu Asp Gln Leu Ser Arg Leu Gly Ser Ser Ser Leu Thr Asn Ile Pro
145                 150                 155                 160 
Glu Glu Val Arg Glu His Val Lys Leu Leu Leu Asn Val Thr Pro Thr
                165                 170                 175     
Val Arg Pro Asp Ala Asp Gln Met Thr Lys Ile Pro Phe Phe Asp Asp
            180                 185                 190         
Val Gly Ala Val Thr Leu Gln Tyr Phe Asp Thr Leu Phe Gln Arg Asp
        195                 200                 205             
Asn Leu Gln Lys Ser Gln Phe Phe Lys Gly Leu Pro Lys Val Leu Pro
    210                 215                 220                 
Lys Leu Pro Lys Arg Val Ile Val Gln Arg Ile Leu Pro Cys Leu Thr
225                 230                 235                 240 
Ser Glu Phe Val Asn Pro Asp Met Val Pro Phe Val Leu Pro Asn Val
                245                 250                 255     
Leu Leu Ile Ala Glu Glu Cys Thr Lys Glu Glu Tyr Val Lys Leu Ile
            260                 265                 270         
Leu Pro Glu Leu Gly Pro Val Phe Lys Gln Gln Glu Pro Ile Gln Ala
        275                 280                 285             
Ser Asn Met Ile Leu Leu Ile Phe Leu Gln Lys Met Asp Leu Leu Leu
    290                 295                 300                 
Thr Lys Thr Pro Pro Asp Glu Ile Lys Asn Ser Val Leu Pro Met Val
305                 310                 315                 320 
Tyr Arg Ala Leu Glu Ala Pro Ser Ile Gln Ile Gln Glu Leu Cys Leu
                325                 330                 335     
Asn Ile Ile Pro Thr Phe Ala Asn Leu Ile Asp Tyr Pro Ser Met Lys
            340                 345                 350         
Asn Ala Leu Ile Pro Arg Ile Lys Asn Ala Cys Leu Gln Thr Ser Ser
        355                 360                 365             
Leu Ala Val Arg Val Asn Ser Leu Val Cys Leu Gly Lys Ile Leu Glu
    370                 375                 380                 
Tyr Leu Asp Lys Trp Phe Val Leu Asp Asp Ile Leu Pro Phe Leu Gln
385                 390                 395                 400 
Gln Ile Pro Ser Lys Glu Pro Ala Val Leu Met Gly Ile Leu Gly Ile
                405                 410                 415     
Tyr Lys Cys Thr Phe Thr His Lys Lys Leu Gly Ile Thr Lys Glu Gln
            420                 425                 430         
Leu Ala Gly Lys Val Leu Pro His Leu Ile Pro Leu Ser Ile Glu Asn
        435                 440                 445             
Asn Leu Asn Leu Asn Gln Phe Asn Ser Phe Ile Ser Val Ile Lys Glu
    450                 455                 460                 
Met Leu Asn Arg Leu Glu Ser Glu His Lys Thr Lys Leu Glu Gln Leu
465                 470                 475                 480 
His Ile Met Gln Glu Gln Gln Lys Ser Leu Asp Ile Gly Asn Gln Met
                485                 490                 495     
Asn Val Ser Glu Glu Met Lys Val Thr Asn Ile Gly Asn Gln Gln Ile
            500                 505                 510         
Asp Lys Val Phe Asn Asn Ile Gly Ala Asp Leu Leu Thr Gly Ser Glu
        515                 520                 525             
Ser Glu Asn Lys Glu Asp Gly Leu Gln Asn Lys His Lys Arg Ala Ser
    530                 535                 540                 
Leu Thr Leu Glu Glu Lys Gln Lys Leu Ala Lys Glu Gln Glu Gln Ala
545                 550                 555                 560 
Gln Lys Leu Lys Ser Gln Gln Pro Leu Lys Pro Gln Val His Thr Pro
                565                 570                 575     
Val Ala Thr Val Lys Gln Thr Lys Asp Leu Thr Asp Thr Leu Met Asp
            580                 585                 590         
Asn Met Ser Ser Leu Thr Ser Leu Ser Val Ser Thr Pro Lys Ser Ser
        595                 600                 605             
Ala Ser Ser Thr Phe Thr Ser Val Pro Ser Met Gly Ile Gly Met Met
    610                 615                 620                 
Phe Ser Thr Pro Thr Asp Asn Thr Lys Arg Asn Leu Thr Asn Gly Leu
625                 630                 635                 640 
Asn Ala Asn Met Gly Phe Gln Thr Ser Gly Phe Asn Met Pro Val Asn
                645                 650                 655     
Thr Asn Gln Asn Phe Tyr Ser Ser Pro Ser Thr Val Gly Val Thr Lys
            660                 665                 670         
Met Thr Leu Gly Thr Pro Pro Thr Leu Pro Asn Phe Asn Ala Leu Ser
        675                 680                 685             
Val Pro Pro Ala Gly Ala Lys Gln Thr Gln Gln Arg Pro Thr Asp Met
    690                 695                 700                 
Ser Ala Leu Asn Asn Leu Phe Gly Pro Gln Lys Pro Lys Val Ser Met
705                 710                 715                 720 
Asn Gln Leu Ser Gln Gln Lys Pro Asn Gln Trp Leu Asn Gln Phe Val
                725                 730                 735     
Pro Pro Gln Gly Ser Pro Thr Met Gly Ser Ser Val Met Gly Thr Gln
            740                 745                 750         
Met Asn Val Ile Gly Gln Ser Ala Phe Gly Met Gln Gly Asn Pro Phe
        755                 760                 765             
Phe Asn Pro Gln Asn Phe Ala Gln Pro Pro Thr Thr Met Thr Asn Ser
    770                 775                 780                 
Ser Ser Ala Ser Asn Asp Leu Lys Asp Leu Phe Gly
785                 790                 795     


<210> 6769
<211> 1057
<212> PRT
<213> Homo sapiens

<400> 6769
Met Met Lys Phe Pro Phe Arg Arg Gln Gly Ala Asp Pro Gln Arg Glu
 1               5                  10                  15      
Lys Leu Lys Gln Glu Leu Phe Ala Phe Asn Lys Thr Val Glu His Gly
            20                  25                  30          
Phe Pro Asn Gln Pro Ser Ala Leu Ala Phe Asp Pro Glu Leu Arg Ile
        35                  40                  45              
Met Ala Ile Gly Thr Arg Ser Gly Ala Val Lys Ile Tyr Gly Ala Pro
    50                  55                  60                  
Gly Val Glu Phe Thr Gly Leu His Arg Asp Ala Ala Thr Val Thr Gln
65                  70                  75                  80  
Met His Phe Leu Thr Gly Gln Gly Arg Leu Leu Ser Leu Leu Asp Asp
                85                  90                  95      
Ser Ser Leu His Leu Trp Glu Ile Val His His Asn Gly Cys Ala His
            100                 105                 110         
Leu Glu Glu Ala Leu Ser Phe Gln Leu Pro Ser Arg Pro Gly Phe Asp
        115                 120                 125             
Gly Ala Ser Ala Pro Leu Ser Leu Thr Arg Val Thr Val Val Leu Leu
    130                 135                 140                 
Val Ala Ala Gly Asp Ile Ala Ala Leu Gly Thr Glu Gly Ser Ser Ser
145                 150                 155                 160 
Val Phe Phe Leu Asp Val Thr Thr Leu Thr Leu Leu Glu Gly Gln Thr
                165                 170                 175     
Leu Ala Pro Gly Glu Val Leu Arg Ser Val Pro Asp Asp Tyr Arg Cys
            180                 185                 190         
Gly Lys Asp Leu Gly Pro Val Glu Ser Leu Gln Gly His Leu Gln Asp
        195                 200                 205             
Pro Thr Lys Ile Leu Ile Gly Tyr Ser Arg Gly Leu Leu Val Ile Arg
    210                 215                 220                 
Asn Gln Ala Ser Gln Cys Val Asp His Ile Phe Leu Gly Asn Gln Gln
225                 230                 235                 240 
Leu Glu Ser Leu Cys Trp Gly Arg Asp Ser Ser Thr Val Val Ser Ser
                245                 250                 255     
His Ser Asp Gly Ser Tyr Ala Val Trp Ser Val Asp Ala Gly Ser Phe
            260                 265                 270         
Pro Thr Leu Gln Pro Thr Val Ala Thr Thr Pro Tyr Gly Pro Phe Pro
        275                 280                 285             
Cys Lys Ala Ile Asn Lys Ile Leu Trp Arg Asn Cys Glu Ser Gly Gly
    290                 295                 300                 
His Phe Ile Ile Phe Ser Gly Gly Met Pro Arg Ala Ser Tyr Gly Asp
305                 310                 315                 320 
Arg His Cys Val Ser Val Leu Arg Ala Glu Thr Leu Val Thr Leu Asp
                325                 330                 335     
Phe His Phe Arg Ile Ile Asp Phe Phe Thr Val His Ser Thr Arg Pro
            340                 345                 350         
Glu Asp Glu Phe Asp Asp Pro Gln Ala Leu Ala Val Leu Leu Glu Glu
        355                 360                 365             
Glu Leu Val Val Leu Asp Leu Gln Thr Pro Gly Trp Pro Ala Val Pro
    370                 375                 380                 
Ala Pro Tyr Leu Ala Pro Leu His Ser Ser Ala Ile Thr Cys Ser Ala
385                 390                 395                 400 
His Val Ala Ser Val Pro Ala Lys Leu Trp Ala Arg Ile Val Ser Ala
                405                 410                 415     
Gly Glu Gln Gln Ser Pro Gln Pro Val Ser Ser Ala Leu Ser Trp Pro
            420                 425                 430         
Ile Thr Gly Gly Arg Asn Leu Ala Gln Glu Pro Ser Gln Arg Gly Leu
        435                 440                 445             
Leu Leu Thr Gly His Glu Asp Gly Thr Val Arg Phe Trp Asp Ala Ser
    450                 455                 460                 
Gly Val Ala Leu Arg Pro Leu Tyr Lys Leu Ser Thr Ala Gly Leu Phe
465                 470                 475                 480 
Gln Thr Asp Cys Glu His Ser Asp Ser Leu Ala Gln Ala Ala Glu Asp
                485                 490                 495     
Asp Trp Pro Pro Phe Arg Lys Val Gly Cys Phe Asp Pro Tyr Ser Asp
            500                 505                 510         
Asp Pro Arg Leu Gly Val Gln Lys Val Ala Leu Cys Lys Tyr Thr Ala
        515                 520                 525             
Gln Met Val Val Ala Gly Thr Ala Gly Gln Val Leu Val Leu Glu Leu
    530                 535                 540                 
Ser Asp Val Pro Val Glu His Ala Val Ser Val Ala Ile Ile Asp Leu
545                 550                 555                 560 
Leu Gln Asp Arg Glu Gly Phe Thr Trp Lys Gly His Glu Arg Leu Ser
                565                 570                 575     
Pro Arg Thr Gly Leu Leu Pro Trp Pro Ala Gly Phe Gln Pro Cys Val
            580                 585                 590         
Leu Val Gln Cys Leu Pro Pro Ala Ala Val Thr Ala Val Thr Leu His
        595                 600                 605             
Thr Glu Trp Ser Leu Val Ala Phe Gly Thr Ser His Gly Phe Gly Leu
    610                 615                 620                 
Leu Ser Pro Val Leu Ala Arg Cys Thr Leu His Pro Asn Asp Ser Leu
625                 630                 635                 640 
Ala Met Glu Gly Pro Leu Ser Arg Val Lys Ser Leu Lys Lys Ser Leu
                645                 650                 655     
Arg Gln Ser Phe Arg Arg Ile Arg Lys Ser Arg Val Ser Gly Lys Lys
            660                 665                 670         
Arg Ala Ala Asn Ala Ser Ser Lys Leu Gln Glu Ala Asn Ala Gln Leu
        675                 680                 685             
Ala Glu Gln Ala Cys Pro His Asp Val Glu Met Thr Pro Val Gln Arg
    690                 695                 700                 
Arg Ile Glu Pro Arg Ser Ala Asp Asp Ser Leu Ser Gly Val Val Arg
705                 710                 715                 720 
Cys Leu Tyr Phe Ala Asp Thr Phe Leu Arg Asp Gly Ala His His Gly
                725                 730                 735     
Pro Thr Met Trp Ala Gly Thr Asn Ser Gly Ser Val Phe Ala Tyr Ala
            740                 745                 750         
Leu Glu Val Pro Ala Ala Ala Val Gly Gly Glu Lys Arg Pro Glu Gln
        755                 760                 765             
Ala Val Glu Ala Val Leu Gly Lys Glu Leu Gln Leu Met His Arg Ala
    770                 775                 780                 
Pro Val Val Ala Ile Ala Val Leu Asp Gly Gly Arg Pro Leu Pro Glu
785                 790                 795                 800 
Pro Tyr Glu Ala Ser Arg Asp Leu Ala Gln Ala Pro His Met Gln Gly
                805                 810                 815     
Gly His Ala Val Leu Ile Ala Ser Glu Glu Gln Phe Lys Val Phe Thr
            820                 825                 830         
Leu Pro Lys Val Ser Ala Lys Thr Lys Phe Lys Leu Thr Ala His Glu
        835                 840                 845             
Gly Cys Arg Val Arg Lys Val Val Ala Leu Ala Thr Phe Ala Ser Val
    850                 855                 860                 
Ala Cys Glu Asp Tyr Ala Glu Thr Cys Leu Ala Cys Leu Thr Asn Leu
865                 870                 875                 880 
Gly Asp Val His Val Phe Ser Val Pro Gly Leu Arg Pro Glu Val His
                885                 890                 895     
Tyr Ser Cys Ile Arg Lys Glu Asp Ile Ser Gly Ile Ala Ser Cys Val
            900                 905                 910         
Phe Thr Arg His Gly Gln Gly Phe Tyr Leu Ile Ser Pro Ser Glu Phe
        915                 920                 925             
Glu Arg Phe Ser Leu Ser Ala Arg Asn Ile Thr Glu Gly Leu Cys Ser
    930                 935                 940                 
Leu Asp Ile Asn Trp Pro Arg Asp Ala Thr Gln Ala Ser Tyr Arg Ile
945                 950                 955                 960 
Arg Glu Ser Pro Lys Leu Ser Gln Ala Asn Gly Thr Pro Ser Ile Leu
                965                 970                 975     
Leu Ala Pro Gln Ser Leu Asp Gly Ser Pro Asp Pro Ala His Ser Met
            980                 985                 990         
Gly Pro Asp Thr Pro Glu Pro Pro Glu Ala Ala Leu Ser Pro Met Ser
        995                 1000                1005            
Ile Asp Ser Ala Thr Ser Ala Asp Thr Thr Leu Asp Thr Thr Gly Asp
    1010                1015                1020                
Val Thr Val Glu Asp Val Lys Asp Phe Leu Gly Ser Ser Glu Glu Ser
1025                1030                1035                1040
Glu Lys Asn Leu Arg Asn Leu Ala Glu Asp Glu Ala His Ala Cys Cys
                1045                1050                1055    
Ile
    


<210> 6770
<211> 1061
<212> PRT
<213> Homo sapiens

<400> 6770
Met Met Lys Phe Arg Phe Arg Arg Gln Gly Ala Asp Pro Gln Arg Glu
 1               5                  10                  15      
Lys Leu Lys Gln Glu Leu Phe Ala Phe Asn Lys Thr Val Glu His Gly
            20                  25                  30          
Phe Pro Asn Gln Pro Ser Ala Leu Ala Phe Asp Pro Glu Leu Arg Ile
        35                  40                  45              
Met Ala Ile Gly Thr Arg Ser Gly Ala Val Lys Ile Tyr Gly Ala Pro
    50                  55                  60                  
Gly Val Glu Phe Thr Gly Leu His Arg Asp Ala Ala Thr Val Thr Gln
65                  70                  75                  80  
Met His Phe Leu Thr Gly Gln Gly Arg Leu Leu Ser Leu Leu Asp Asp
                85                  90                  95      
Ser Ser Leu His Leu Trp Glu Ile Val His His Asn Gly Cys Ala His
            100                 105                 110         
Leu Glu Glu Ala Leu Ser Phe Gln Leu Pro Ser Arg Pro Gly Phe Asp
        115                 120                 125             
Gly Ala Ser Ala Pro Leu Ser Leu Thr Arg Val Thr Val Val Leu Leu
    130                 135                 140                 
Val Ala Ala Ser Asp Ile Ala Ala Leu Gly Thr Glu Gly Ser Ser Val
145                 150                 155                 160 
Phe Phe Leu Asp Val Thr Thr Leu Thr Leu Leu Glu Gly Gln Thr Leu
                165                 170                 175     
Ala Pro Gly Glu Val Leu Arg Ser Val Pro Asp Asp Tyr Arg Cys Gly
            180                 185                 190         
Lys Ala Leu Gly Pro Val Glu Ser Leu Gln Gly His Leu Arg Asp Pro
        195                 200                 205             
Thr Lys Ile Leu Ile Gly Tyr Ser Arg Gly Leu Leu Val Ile Trp Asn
    210                 215                 220                 
Gln Ala Ser Gln Cys Val Asp His Ile Phe Leu Gly Asn Gln Gln Leu
225                 230                 235                 240 
Glu Ser Leu Cys Trp Gly Arg Asp Ser Ser Thr Val Val Ser Ser His
                245                 250                 255     
Ser Asp Gly Ser Tyr Ala Val Trp Ser Val Asp Ala Gly Ser Phe Pro
            260                 265                 270         
Thr Leu Gln Pro Thr Val Ala Thr Thr Pro Tyr Gly Pro Phe Pro Cys
        275                 280                 285             
Lys Ala Ile Asn Lys Ile Leu Trp Arg Asn Cys Glu Ser Gly Gly His
    290                 295                 300                 
Phe Ile Ile Phe Ser Gly Gly Met Pro Arg Ala Ser Tyr Gly Asp Arg
305                 310                 315                 320 
His Cys Val Ser Val Leu Arg Ala Glu Thr Leu Val Thr Leu Asp Phe
                325                 330                 335     
Thr Ser Arg Ile Ile Asp Phe Phe Thr Val His Ser Thr Arg Pro Glu
            340                 345                 350         
Asp Glu Phe Asp Asp Pro Gln Ala Leu Ala Val Leu Leu Glu Glu Glu
        355                 360                 365             
Leu Val Val Leu Asp Leu Gln Thr Pro Gly Trp Pro Ala Val Pro Ala
    370                 375                 380                 
Pro Tyr Leu Ala Pro Leu His Ser Ser Ala Ile Thr Cys Ser Ala His
385                 390                 395                 400 
Val Ala Ser Val Pro Ala Lys Leu Trp Ala Arg Ile Val Ser Ala Gly
                405                 410                 415     
Glu Gln Gln Ser Pro Gln Pro Val Ser Ser Ala Leu Ser Trp Pro Ile
            420                 425                 430         
Thr Gly Gly Arg Asn Leu Ala Gln Glu Pro Ser Gln Arg Gly Leu Leu
        435                 440                 445             
Leu Thr Gly His Glu Asp Gly Thr Val Arg Phe Trp Asp Ala Ser Gly
    450                 455                 460                 
Val Ala Leu Arg Pro Leu Tyr Lys Leu Ser Thr Ala Gly Leu Phe Gln
465                 470                 475                 480 
Thr Asp Cys Glu His Ala Asp Ser Leu Ala Gln Ala Ala Glu Asp Asp
                485                 490                 495     
Trp Pro Pro Phe Arg Lys Val Gly Cys Phe Asp Pro Tyr Ser Asp Asp
            500                 505                 510         
Pro Arg Leu Gly Val Gln Lys Val Ala Leu Cys Lys Tyr Thr Ala Gln
        515                 520                 525             
Met Val Val Ala Gly Thr Ala Gly Gln Val Leu Val Leu Glu Leu Ser
    530                 535                 540                 
Asp Val Pro Val Glu Gln Ala Val Ser Val Ala Ile Ile Asp Leu Leu
545                 550                 555                 560 
Gln Asp Arg Glu Gly Phe Thr Trp Lys Gly His Glu Arg Leu Ser Pro
                565                 570                 575     
Arg Thr Gly Pro Leu Pro Trp Pro Ala Gly Phe Gln Pro Arg Val Leu
            580                 585                 590         
Val Gln Cys Leu Pro Pro Ala Ala Val Thr Ala Val Thr Leu His Thr
        595                 600                 605             
Glu Trp Ser Leu Val Ala Phe Gly Thr Ser His Gly Phe Gly Leu Phe
    610                 615                 620                 
Asp Tyr Gln Arg Lys Ser Pro Val Leu Ala Arg Cys Thr Leu His Pro
625                 630                 635                 640 
Asn Asp Ser Leu Ala Met Glu Gly Pro Leu Ser Arg Val Lys Ser Leu
                645                 650                 655     
Lys Lys Ser Leu Arg Gln Ser Phe Arg Arg Ile Arg Lys Ser Arg Val
            660                 665                 670         
Ser Gly Lys Lys Arg Ala Ala Asn Ala Ser Ser Lys Leu Gln Glu Ala
        675                 680                 685             
Asn Ala Gln Leu Ala Glu Gln Ala Cys Pro His Asp Val Glu Met Thr
    690                 695                 700                 
Pro Val Gln Arg Arg Ile Glu Pro Arg Ser Ala Asp Asp Ser Leu Ser
705                 710                 715                 720 
Gly Val Val Arg Cys Leu Tyr Phe Ala Asp Thr Phe Leu Arg Asp Gly
                725                 730                 735     
Ala His His Gly Pro Thr Met Trp Ala Gly Thr Asn Ser Gly Ser Val
            740                 745                 750         
Phe Ala Tyr Ala Leu Glu Val Pro Ala Ala Ala Val Gly Gly Glu Lys
        755                 760                 765             
Arg Pro Glu Gln Ala Val Glu Ala Val Leu Gly Lys Glu Val Gln Leu
    770                 775                 780                 
Met His Arg Ala Pro Val Val Ala Ile Ala Val Leu Asp Gly Arg Gly
785                 790                 795                 800 
Arg Pro Leu Pro Glu Pro Tyr Glu Ala Ser Arg Asp Leu Ala Gln Ala
                805                 810                 815     
Pro Asp Met Gln Gly Gly His Ala Val Leu Ile Ala Ser Glu Glu Gln
            820                 825                 830         
Phe Lys Val Phe Thr Leu Pro Lys Val Ser Ala Lys Thr Lys Phe Lys
        835                 840                 845             
Leu Thr Ala His Glu Gly Cys Arg Val Arg Lys Val Ala Leu Ala Thr
    850                 855                 860                 
Phe Ala Ser Val Ala Cys Glu Asp Tyr Ala Glu Thr Cys Leu Ala Cys
865                 870                 875                 880 
Leu Thr Asn Leu Gly Asp Val His Val Phe Ser Val Pro Gly Leu Arg
                885                 890                 895     
Pro Gln Val His Tyr Ser Cys Ile Arg Lys Glu Asp Ile Ser Gly Ile
            900                 905                 910         
Ala Ser Cys Val Phe Thr Arg His Gly Gln Gly Phe Tyr Leu Ile Ser
        915                 920                 925             
Pro Ser Glu Phe Glu Arg Phe Ser Leu Ser Ala Arg Asn Ile Thr Glu
    930                 935                 940                 
Pro Leu Cys Ser Leu Asp Ile Asn Trp Pro Arg Asp Ala Thr Gln Ala
945                 950                 955                 960 
Ser Tyr Arg Ile Arg Glu Ser Pro Lys Leu Ser Gln Ala Asn Gly Thr
                965                 970                 975     
Pro Ser Ile Leu Leu Ala Pro Gln Ser Leu Asp Gly Ser Pro Asp Pro
            980                 985                 990         
Ala His Ser Met Gly Pro Asp Thr Pro Glu Pro Pro Glu Ala Ala Leu
        995                 1000                1005            
Ser Pro Met Ser Ile Asp Ser Ala Thr Ser Ala Asp Thr Thr Leu Asp
    1010                1015                1020                
Thr Thr Gly Asp Val Thr Val Glu Asp Val Lys Asp Phe Leu Gly Ser
1025                1030                1035                1040
Ser Glu Glu Ser Glu Lys Asn Leu Arg Asn Leu Ala Glu Asp Glu Ala
                1045                1050                1055    
His Ala Cys Ala Ile
            1060    


<210> 6771
<211> 1032
<212> PRT
<213> Homo sapiens

<400> 6771
Met Met Lys Phe Arg Phe Arg Arg Gln Gly Ala Asp Pro Gln Arg Glu
 1               5                  10                  15      
Lys Leu Lys Gln Glu Leu Phe Ala Phe Asn Lys Thr Val Glu His Gly
            20                  25                  30          
Phe Pro Asn Gln Pro Ser Ala Leu Ala Phe Asp Pro Glu Leu Arg Ile
        35                  40                  45              
Met Ala Ile Gly Thr Arg Ser Gly Ala Val Lys Ile Tyr Gly Ala Pro
    50                  55                  60                  
Gly Val Glu Phe Thr Gly Leu His Arg Asp Ala Ala Thr Val Thr Gln
65                  70                  75                  80  
Met His Phe Leu Thr Gly Gln Gly Arg Leu Leu Ser Leu Leu Asp Asp
                85                  90                  95      
Ser Ser Leu His Leu Trp Glu Ile Val His His Asn Gly Cys Ala His
            100                 105                 110         
Leu Glu Glu Ala Leu Ser Phe Gln Leu Pro Ser Arg Pro Gly Phe Asp
        115                 120                 125             
Gly Ala Ser Ala Pro Leu Ser Leu Thr Arg Val Thr Val Val Leu Leu
    130                 135                 140                 
Val Ala Ala Gly Asp Ile Ala Gly Leu Gly Thr Glu Gly Ser Ser Val
145                 150                 155                 160 
Phe Phe Leu Asp Val Thr Thr Leu Thr Leu Leu Glu Gly Gln Thr Leu
                165                 170                 175     
Ala Pro Gly Glu Val Leu Arg Ser Val Pro Asp Asp Tyr Arg Cys Gly
            180                 185                 190         
Lys Ala Leu Gly Pro Val Glu Ser Leu Gln Gly His Cys Gly Thr Pro
        195                 200                 205             
Gln Arg Phe Ser Leu Ala Thr Asp Arg Gly Leu Leu Val Ile Trp Asn
    210                 215                 220                 
Gln Ser Arg Gln Cys Val Asp His Ile Phe Leu Gly Asn Gln Gln Leu
225                 230                 235                 240 
Glu Ser Leu Cys Trp Gly Arg Asp Ser Ser Thr Val Val Ser Ser His
                245                 250                 255     
Ser Asp Gly Ser Tyr Ala Val Trp Ser Val Asp Ala Gly Ser Phe Pro
            260                 265                 270         
Thr Leu Gln Pro Thr Val Ala Thr Thr Pro Tyr Gly Pro Phe Pro Cys
        275                 280                 285             
Lys Ala Ile Asn Lys Ile Leu Trp Arg Asn Cys Glu Ser Gly Gly His
    290                 295                 300                 
Phe Ile Ile Phe Ser Gly Gly Met Pro Arg Ala Ser Tyr Gly Asp Arg
305                 310                 315                 320 
His Cys Val Ser Val Leu Arg Ala Glu Thr Leu Val Thr Leu Asp Phe
                325                 330                 335     
Thr Ser Arg Ile Ile Asp Phe Phe Thr Val His Ser Thr Arg Pro Glu
            340                 345                 350         
Asp Glu Phe Asp Asp Pro Gln Ala Leu Ala Val Leu Leu Glu Glu Glu
        355                 360                 365             
Leu Val Val Leu Asp Leu Gln Thr Pro Gly Trp Pro Ala Val Pro Ala
    370                 375                 380                 
Pro Tyr Leu Ala Pro Leu His Ser Ser Ala Ile Thr Cys Ser Ala Tyr
385                 390                 395                 400 
Val Ala Ser Val Pro Ala Lys Leu Trp Ala Arg Ile Val Ser Ala Gly
                405                 410                 415     
Glu Gln Gln Ser Pro Gln Pro Val Ser Ser Ala Leu Ser Trp Pro Ile
            420                 425                 430         
Thr Gly Gly Arg Asn Leu Ala Gln Glu Pro Ser Gln Arg Gly Leu Leu
        435                 440                 445             
Leu Thr Gly His Glu Asp Gly Thr Val Arg Phe Trp Asp Ala Ser Gly
    450                 455                 460                 
Val Ala Leu Arg Pro Leu Tyr Lys Leu Ser Thr Ala Gly Leu Phe Gln
465                 470                 475                 480 
Thr Asp Cys Glu His Ala Asp Ser Leu Ala Gln Ala Ala Glu Asp Asp
                485                 490                 495     
Trp Pro Pro Phe Arg Lys Val Gly Cys Phe Asp Pro Tyr Ser Asp Asp
            500                 505                 510         
Pro Arg Leu Gly Val Gln Lys Val Ala Leu Cys Lys Tyr Thr Ala Gln
        515                 520                 525             
Met Val Val Ala Gly Thr Ala Gly Gln Val Leu Val Leu Glu Leu Ser
    530                 535                 540                 
Asp Val Pro Val Glu Gln Ala Val Ser Val Ala Ile Ile Asp Leu Leu
545                 550                 555                 560 
Gln Asp Arg Glu Gly Phe Thr Trp Lys Gly His Glu Arg Leu Ser Pro
                565                 570                 575     
Arg Thr Gly Pro Leu Pro Trp Pro Ala Gly Phe Leu Pro Arg Val Leu
            580                 585                 590         
Val Gln Cys Leu Pro Pro Ala Ala Val Thr Ala Val Thr Leu His Thr
        595                 600                 605             
Glu Trp Ser Leu Val Ala Phe Gly Thr Ser His Gly Phe Gly Leu Phe
    610                 615                 620                 
Asp Tyr Gln Arg Lys Ser Pro Val Leu Ala Arg Cys Thr Leu His Pro
625                 630                 635                 640 
Asn Asp Ser Leu Ala Met Glu Gly Pro Leu Ser Arg Val Lys Ser Leu
                645                 650                 655     
Lys Lys Ser Leu Arg Gln Ser Phe Arg Arg Ile Arg Lys Ser Arg Val
            660                 665                 670         
Ser Gly Lys Lys Arg Ala Ala Asn Ala Ser Ser Lys Leu Leu Glu Ala
        675                 680                 685             
Asn Ala Gln Leu Ala Glu Gln Ala Cys Pro His Asp Val Glu Met Thr
    690                 695                 700                 
Pro Val Gln Arg Arg Ile Glu Pro Arg Ser Ala Asp Asp Ser Leu Ser
705                 710                 715                 720 
Gly Val Val Arg Cys Leu Tyr Phe Ala Asp Thr Phe Leu Arg Asp Gly
                725                 730                 735     
Pro Thr Thr Gly Pro Thr Met Trp Ala Gly Thr Asn Ser Gly Ser Val
            740                 745                 750         
Phe Ala Tyr Ala Leu Glu Val Pro Ala Ala Ala Val Gly Gly Glu Lys
        755                 760                 765             
Arg Pro Glu Gln Ala Val Glu Ala Val Leu Gly Lys Lys Glu Gln Leu
    770                 775                 780                 
Met His Arg Ala Pro Val Val Ala Ile Cys Arg Val Gly Arg Arg Gly
785                 790                 795                 800 
Arg Pro Leu Pro Glu Pro Tyr Glu Ala Ser Arg Asp Leu Ala Gln Ala
                805                 810                 815     
Pro Asp Met Gln Gly Gly His Ala Val Leu Ile Ala Ser Glu Glu Gln
            820                 825                 830         
Phe Lys Val Phe Thr Leu Pro Lys Val Ser Ala Lys Thr Lys Phe Lys
        835                 840                 845             
Leu Thr Ala His Glu Gly Cys Arg Val Arg Lys Val Ala Leu Ala Thr
    850                 855                 860                 
Phe Cys Gln Cys Gly Leu Gln Thr Met Leu Arg Pro Ala Trp Pro Val
865                 870                 875                 880 
Leu Thr Asn Leu Gly Asp Val His Val Phe Ser Val Pro Leu Arg Pro
                885                 890                 895     
Gln Val His Tyr Ser Cys Ile Arg Lys Glu Asp Ile Ser Gly Ile Ala
            900                 905                 910         
Ser Cys Val Phe Thr Arg His Gly Gln Gly Phe Tyr Leu Ile Ser Pro
        915                 920                 925             
Ser Glu Phe Glu Arg Phe Ser Leu Ser Ala Arg Asn Ile Thr Glu Arg
    930                 935                 940                 
Ser Ala Leu Trp Thr Leu Thr Gly Pro Ala Met Pro Pro Arg Pro Val
945                 950                 955                 960 
Thr Gly Ser Glu Ser His Pro Lys Leu Ser Gln Ala Asn Gly Thr Pro
                965                 970                 975     
Ser Ile Leu Leu Ala Pro Gln Ser Leu Asp Gly Ser Pro Asp Pro Ala
            980                 985                 990         
His Ser Met Gly Pro Asp Thr Pro Glu Pro Pro Glu Ala Ala Leu Ser
        995                 1000                1005            
Pro Met Ser Ile Asp Ser Ala Thr Ser Ala Asp Thr Thr Leu Thr Arg
    1010                1015                1020                
Gln Gly Thr Ser Gln Trp Lys Met
1025                1030        


<210> 6772
<211> 599
<212> PRT
<213> Homo sapiens

<400> 6772
Met Glu Asn Cys Leu Gly Glu Ser Arg His Glu Val Glu Lys Ser Glu
 1               5                  10                  15      
Ile Ser Glu Asn Thr Asp Ala Ser Gly Lys Ile Glu Lys Tyr Asn Val
            20                  25                  30          
Pro Leu Asn Arg Leu Lys Met Met Phe Glu Lys Gly Glu Pro Thr Gln
        35                  40                  45              
Thr Lys Ile Leu Arg Ala Gln Ser Arg Ser Ala Ser Gly Arg Lys Ile
    50                  55                  60                  
Ser Glu Asn Ser Tyr Ser Leu Asp Asp Leu Glu Ile Gly Pro Gly Gln
65                  70                  75                  80  
Leu Ser Ser Ser Thr Phe Asp Ser Glu Lys Asn Glu Ser Arg Arg Asn
                85                  90                  95      
Leu Glu Leu Pro Arg Leu Ser Glu Thr Ser Ile Lys Asp Arg Met Ala
            100                 105                 110         
Lys Tyr Gln Ala Ala Val Ser Lys Gln Ser Ser Ser Thr Asn Tyr Thr
        115                 120                 125             
Asn Glu Leu Lys Ala Ser Gly Gly Glu Ile Lys Ile His Lys Met Glu
    130                 135                 140                 
Gln Lys Glu Asn Val Pro Pro Gly Pro Glu Val Cys Ile Thr His Gln
145                 150                 155                 160 
Glu Gly Glu Lys Ile Ser Ala Asn Glu Asn Ser Leu Ala Val Arg Ser
                165                 170                 175     
Thr Pro Ala Glu Asp Asp Ser Arg Asp Ser Gln Val Lys Ser Glu Val
            180                 185                 190         
Gln Gln Pro Val His Pro Lys Pro Leu Ser Pro Asp Ser Arg Ala Ser
        195                 200                 205             
Ser Leu Ser Glu Ser Ser Pro Pro Lys Ala Met Lys Lys Phe Gln Ala
    210                 215                 220                 
Pro Ala Arg Glu Thr Cys Val Glu Cys Gln Lys Thr Val Tyr Pro Met
225                 230                 235                 240 
Glu Arg Leu Leu Ala Asn Gln Gln Val Phe His Ile Ser Cys Phe Arg
                245                 250                 255     
Cys Ser Tyr Cys Asn Asn Lys Leu Ser Leu Gly Thr Tyr Ala Ser Leu
            260                 265                 270         
His Gly Arg Ile Tyr Cys Lys Pro His Phe Asn Gln Leu Phe Lys Ser
        275                 280                 285             
Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Arg Pro His Lys Asp Leu
    290                 295                 300                 
Trp Ala Ser Lys Asn Glu Asn Glu Glu Ile Leu Glu Arg Pro Ala Gln
305                 310                 315                 320 
Leu Ala Asn Ala Arg Glu Thr Pro His Ser Pro Gly Val Glu Asp Ala
                325                 330                 335     
Pro Ile Ala Lys Val Gly Val Leu Ala Ala Ser Met Glu Ala Lys Ala
            340                 345                 350         
Ser Ser Gln Gln Glu Lys Glu Asp Lys Pro Ala Glu Thr Lys Lys Leu
        355                 360                 365             
Arg Ile Ala Trp Pro Pro Pro Thr Glu Leu Gly Ser Ser Gly Ser Ala
    370                 375                 380                 
Leu Glu Glu Gly Ile Lys Met Ser Lys Pro Lys Trp Pro Pro Glu Asp
385                 390                 395                 400 
Glu Ile Ser Lys Pro Glu Val Pro Glu Asp Val Asp Leu Asp Leu Lys
                405                 410                 415     
Lys Leu Arg Arg Ser Ser Ser Leu Lys Glu Arg Ser Arg Pro Phe Thr
            420                 425                 430         
Val Ala Ala Ser Phe Gln Ser Thr Ser Val Lys Ser Pro Lys Thr Val
        435                 440                 445             
Ser Pro Pro Ile Arg Lys Gly Trp Ser Met Ser Glu Gln Ser Glu Glu
    450                 455                 460                 
Ser Val Gly Gly Arg Val Ala Glu Arg Lys Gln Val Glu Asn Ala Lys
465                 470                 475                 480 
Ala Ser Lys Lys Asn Gly Asn Val Gly Lys Thr Thr Trp Gln Asn Lys
                485                 490                 495     
Glu Ser Lys Gly Glu Thr Gly Lys Arg Ser Lys Glu Gly His Ser Leu
            500                 505                 510         
Glu Met Glu Asn Glu Asn Leu Val Glu Asn Gly Ala Asp Ser Asp Glu
        515                 520                 525             
Asp Asp Asn Ser Phe Leu Lys Gln Gln Ser Pro Gln Glu Pro Lys Ser
    530                 535                 540                 
Leu Asn Trp Ser Ser Phe Val Asp Asn Thr Phe Ala Glu Glu Phe Thr
545                 550                 555                 560 
Thr Gln Asn Gln Lys Ser Gln Asp Val Glu Leu Trp Glu Gly Glu Val
                565                 570                 575     
Val Lys Glu Leu Ser Val Glu Glu Gln Ile Lys Arg Asn Arg Tyr Tyr
            580                 585                 590         
Asp Glu Asp Glu Asp Glu Glu
        595                 


<210> 6773
<211> 759
<212> PRT
<213> Homo sapiens

<400> 6773
Met Glu Ser Ser Pro Phe Asn Arg Arg Gln Trp Thr Ser Leu Ser Leu
 1               5                  10                  15      
Arg Val Thr Ala Lys Glu Leu Ser Leu Val Asn Lys Asn Lys Ser Ser
            20                  25                  30          
Ala Ile Val Glu Ile Phe Ser Lys Tyr Gln Lys Ala Ala Glu Glu Thr
        35                  40                  45              
Asn Met Glu Lys Lys Arg Ser Asn Thr Glu Asn Leu Ser Gln His Phe
    50                  55                  60                  
Arg Lys Gly Thr Leu Thr Val Leu Lys Lys Lys Trp Glu Asn Pro Gly
65                  70                  75                  80  
Leu Gly Ala Glu Ser His Thr Asp Ser Leu Arg Asn Ser Ser Thr Glu
                85                  90                  95      
Ile Arg His Arg Ala Asp His Pro Pro Ala Glu Val Thr Ser His Ala
            100                 105                 110         
Ala Ser Gly Ala Lys Ala Asp Gln Glu Glu Gln Ile His Pro Arg Ser
        115                 120                 125             
Arg Leu Arg Ser Pro Pro Glu Ala Leu Val Gln Gly Arg Tyr Pro His
    130                 135                 140                 
Ile Lys Asp Gly Glu Asp Leu Lys Asp His Ser Thr Glu Ser Lys Lys
145                 150                 155                 160 
Met Glu Asn Cys Leu Gly Glu Ser Arg His Glu Val Glu Lys Ser Glu
                165                 170                 175     
Ile Ser Glu Asn Thr Asp Ala Ser Gly Lys Ile Glu Lys Tyr Asn Val
            180                 185                 190         
Pro Leu Asn Arg Leu Lys Met Met Phe Glu Lys Gly Glu Pro Thr Gln
        195                 200                 205             
Thr Lys Ile Leu Arg Ala Gln Ser Arg Ser Ala Ser Gly Arg Lys Ile
    210                 215                 220                 
Ser Glu Asn Ser Tyr Ser Leu Asp Asp Leu Glu Ile Gly Pro Gly Gln
225                 230                 235                 240 
Leu Ser Ser Ser Thr Phe Asp Ser Glu Lys Asn Glu Ser Arg Arg Asn
                245                 250                 255     
Leu Glu Leu Pro Arg Leu Ser Glu Thr Ser Ile Lys Asp Arg Met Ala
            260                 265                 270         
Lys Tyr Gln Ala Ala Val Ser Lys Gln Ser Ser Ser Thr Asn Tyr Thr
        275                 280                 285             
Asn Glu Leu Lys Ala Ser Gly Gly Glu Ile Lys Ile His Lys Met Glu
    290                 295                 300                 
Gln Lys Glu Asn Val Pro Pro Gly Pro Glu Val Cys Ile Thr His Gln
305                 310                 315                 320 
Glu Gly Glu Lys Ile Ser Ala Asn Glu Asn Ser Leu Ala Val Arg Ser
                325                 330                 335     
Thr Pro Ala Glu Asp Asp Ser Arg Asp Ser Gln Val Lys Ser Glu Val
            340                 345                 350         
Gln Gln Pro Val His Pro Lys Pro Leu Ser Pro Asp Ser Arg Ala Ser
        355                 360                 365             
Ser Leu Ser Glu Ser Ser Pro Pro Lys Ala Met Lys Lys Phe Gln Ala
    370                 375                 380                 
Pro Ala Arg Glu Thr Cys Val Glu Cys Gln Lys Thr Val Tyr Pro Met
385                 390                 395                 400 
Glu Arg Leu Leu Ala Asn Gln Gln Val Phe His Ile Ser Cys Phe Arg
                405                 410                 415     
Cys Ser Tyr Cys Asn Asn Lys Leu Ser Leu Gly Thr Tyr Ala Ser Leu
            420                 425                 430         
His Gly Arg Ile Tyr Cys Lys Pro His Phe Asn Gln Leu Phe Lys Ser
        435                 440                 445             
Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Arg Pro His Lys Asp Leu
    450                 455                 460                 
Trp Ala Ser Lys Asn Glu Asn Glu Glu Ile Leu Glu Arg Pro Ala Gln
465                 470                 475                 480 
Leu Ala Asn Ala Arg Glu Thr Pro His Ser Pro Gly Val Glu Asp Ala
                485                 490                 495     
Pro Ile Ala Lys Val Gly Val Leu Ala Ala Ser Met Glu Ala Lys Ala
            500                 505                 510         
Ser Ser Gln Gln Glu Lys Glu Asp Lys Pro Ala Glu Thr Lys Lys Leu
        515                 520                 525             
Arg Ile Ala Trp Pro Pro Pro Thr Glu Leu Gly Ser Ser Gly Ser Ala
    530                 535                 540                 
Leu Glu Glu Gly Ile Lys Met Ser Lys Pro Lys Trp Pro Pro Glu Asp
545                 550                 555                 560 
Glu Ile Ser Lys Pro Glu Val Pro Glu Asp Val Asp Leu Asp Leu Lys
                565                 570                 575     
Lys Leu Arg Arg Ser Ser Ser Leu Lys Glu Arg Ser Arg Pro Phe Thr
            580                 585                 590         
Val Ala Ala Ser Phe Gln Ser Thr Ser Val Lys Ser Pro Lys Thr Val
        595                 600                 605             
Ser Pro Pro Ile Arg Lys Gly Trp Ser Met Ser Glu Gln Ser Glu Glu
    610                 615                 620                 
Ser Val Gly Gly Arg Val Ala Glu Arg Lys Gln Val Glu Asn Ala Lys
625                 630                 635                 640 
Ala Ser Lys Lys Asn Gly Asn Val Gly Lys Thr Thr Trp Gln Asn Lys
                645                 650                 655     
Glu Ser Lys Gly Glu Thr Gly Lys Arg Ser Lys Glu Gly His Ser Leu
            660                 665                 670         
Glu Met Glu Asn Glu Asn Leu Val Glu Asn Gly Ala Asp Ser Asp Glu
        675                 680                 685             
Asp Asp Asn Ser Phe Leu Lys Gln Gln Ser Pro Gln Glu Pro Lys Ser
    690                 695                 700                 
Leu Asn Trp Ser Ser Phe Val Asp Asn Thr Phe Ala Glu Glu Phe Thr
705                 710                 715                 720 
Thr Gln Asn Gln Lys Ser Gln Asp Val Glu Leu Trp Glu Gly Glu Val
                725                 730                 735     
Val Lys Glu Leu Ser Val Glu Glu Gln Ile Lys Arg Asn Arg Tyr Tyr
            740                 745                 750         
Asp Glu Asp Glu Asp Glu Glu
        755                 


<210> 6774
<211> 705
<212> PRT
<213> Homo sapiens

<400> 6774
Met Thr Ile Glu Asp Leu Pro Asp Phe Pro Leu Glu Gly Asn Pro Leu
 1               5                  10                  15      
Phe Gly Arg Tyr Pro Phe Ile Phe Ser Ala Ser Asp Thr Pro Val Ile
            20                  25                  30          
Phe Ser Ile Ser Ala Ala Pro Met Pro Ser Asp Cys Glu Phe Ser Phe
        35                  40                  45              
Phe Asp Pro Asn Asp Ala Ser Cys Gln Glu Ile Leu Phe Asp Pro Lys
    50                  55                  60                  
Thr Ser Val Ser Glu Leu Phe Ala Ile Leu Arg Gln Trp Val Pro Gln
65                  70                  75                  80  
Val Gln Gln Asn Ile Asp Ile Ile Gly Asn Glu Ile Leu Lys Arg Gly
                85                  90                  95      
Cys Asn Val Asn Asp Arg Asp Gly Leu Thr Asp Met Thr Leu Leu His
            100                 105                 110         
Tyr Thr Cys Lys Ser Gly Ala His Gly Ile Gly Asp Val Glu Thr Ala
        115                 120                 125             
Val Lys Phe Ala Thr Gln Leu Ile Asp Leu Gly Ala Asp Ile Ser Leu
    130                 135                 140                 
Arg Ser Arg Trp Thr Asn Met Asn Ala Leu His Tyr Ala Ala Tyr Phe
145                 150                 155                 160 
Asp Val Pro Glu Leu Ile Arg Val Ile Leu Lys Thr Ser Lys Pro Lys
                165                 170                 175     
Asp Val Asp Ala Thr Cys Ser Asp Phe Asn Phe Gly Thr Ala Leu His
            180                 185                 190         
Ile Ala Ala Tyr Asn Leu Cys Ala Gly Ala Val Lys Cys Leu Leu Glu
        195                 200                 205             
Gln Gly Ala Asn Pro Ala Phe Arg Asn Asp Lys Gly Gln Ile Pro Ala
    210                 215                 220                 
Asp Val Val Pro Asp Pro Val Asp Met Pro Leu Glu Met Ala Asp Ala
225                 230                 235                 240 
Ala Ala Thr Ala Lys Glu Ile Lys Gln Met Leu Leu Asp Ala Val Pro
                245                 250                 255     
Leu Ser Cys Asn Ile Ser Lys Ala Met Leu Pro Asn Tyr Asp His Val
            260                 265                 270         
Thr Gly Lys Ala Met Leu Thr Ser Leu Gly Leu Lys Leu Gly Asp Arg
        275                 280                 285             
Val Val Ile Ala Gly Gln Lys Val Gly Thr Leu Arg Phe Cys Gly Thr
    290                 295                 300                 
Thr Glu Phe Ala Ser Gly Gln Trp Ala Gly Ile Glu Leu Asp Glu Pro
305                 310                 315                 320 
Glu Gly Lys Asn Asn Gly Ser Val Gly Lys Val Gln Tyr Phe Lys Cys
                325                 330                 335     
Ala Pro Lys Tyr Gly Ile Phe Ala Pro Leu Ser Lys Ile Ser Lys Ala
            340                 345                 350         
Lys Gly Arg Arg Lys Asn Ile Thr His Thr Pro Ser Thr Lys Ala Ala
        355                 360                 365             
Val Pro Leu Ile Arg Ser Gln Lys Ile Asp Val Ala His Val Thr Ser
    370                 375                 380                 
Lys Val Asn Thr Gly Leu Met Thr Ser Lys Lys Asp Ser Ala Ser Glu
385                 390                 395                 400 
Ser Thr Leu Ser Leu Pro Pro Gly Glu Glu Leu Lys Thr Val Thr Glu
                405                 410                 415     
Lys Asp Val Ala Leu Leu Gly Ser Val Ser Ser Cys Ser Ser Thr Ser
            420                 425                 430         
Ser Leu Glu His Arg Gln Ser Tyr Pro Lys Lys Gln Asn Ala Ile Ser
        435                 440                 445             
Ser Asn Lys Lys Thr Met Ser Lys Ser Pro Ser Leu Ser Ser Arg Ala
    450                 455                 460                 
Ser Ala Gly Leu Asn Ser Ser Ala Thr Ser Thr Ala Asn Asn Ser Arg
465                 470                 475                 480 
Cys Glu Gly Glu Leu Arg Leu Gly Glu Arg Val Leu Val Val Gly Gln
                485                 490                 495     
Arg Leu Gly Thr Ile Arg Phe Phe Gly Thr Thr Asn Phe Ala Pro Gly
            500                 505                 510         
Tyr Trp Tyr Gly Ile Glu Leu Glu Lys Pro His Gly Lys Asn Asp Gly
        515                 520                 525             
Ser Val Gly Gly Val Gln Tyr Phe Ser Cys Ser Pro Arg Tyr Gly Ile
    530                 535                 540                 
Phe Ala Pro Pro Ser Arg Val Gln Arg Val Thr Asp Ser Leu Asp Thr
545                 550                 555                 560 
Leu Ser Glu Ile Ser Ser Asn Lys Gln Asn His Ser Tyr Pro Gly Phe
                565                 570                 575     
Arg Arg Ser Phe Ser Thr Thr Ser Ala Ser Ser Gln Lys Glu Ile Asn
            580                 585                 590         
Arg Arg Asn Ala Phe Ser Lys Ser Lys Ala Ala Leu Arg Arg Ser Trp
        595                 600                 605             
Ser Ser Thr Pro Thr Ala Gly Gly Ile Glu Gly Ser Val Lys Leu His
    610                 615                 620                 
Glu Gly Ser Gln Val Leu Leu Thr Ser Ser Asn Glu Met Gly Thr Val
625                 630                 635                 640 
Arg Tyr Val Gly Pro Thr Asp Phe Ala Ser Gly Ile Trp Leu Gly Leu
                645                 650                 655     
Glu Leu Arg Ser Ala Lys Gly Lys Asn Asp Gly Ser Val Gly Asp Lys
            660                 665                 670         
Arg Tyr Phe Thr Cys Lys Pro Asn His Gly Val Leu Val Arg Pro Ser
        675                 680                 685             
Arg Val Thr Tyr Arg Gly Ile Asn Gly Ser Lys Leu Val Asp Glu Asn
    690                 695                 700                 
Cys
705 


<210> 6775
<211> 158
<212> PRT
<213> Homo sapiens

<400> 6775
Met Val Asn His Thr Met Phe Phe Asp Val Ala Val Asp Ser Glu Pro
 1               5                  10                  15      
Leu Asp His Val Ser Phe Glu Leu Phe Ala Glu Lys Phe Pro Lys Thr
            20                  25                  30          
Ala Glu Asn Val Arg Ala Leu Ser Thr Glu Glu Lys Gly Phe Gly Tyr
        35                  40                  45              
Lys Gly Pro Cys Phe His Arg Ile Ile Pro Ala Phe Met Cys Gln Gly
    50                  55                  60                  
Gly Asp Phe Thr His His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly
65                  70                  75                  80  
Glu Lys Phe Glu Asp Glu Lys Phe Ile Leu Lys Arg Thr Gly Pro Gly
                85                  90                  95      
Ile Leu Ser Met Ala Asn Ser Gly Pro Asn Thr Asn Cys Ser Val Phe
            100                 105                 110         
His Leu His Cys Gln Asp Gly Val Val Gly Trp Gln Ala Cys Ser Leu
        115                 120                 125             
Trp Gln Gly Glu Arg Arg His Glu Tyr Phe Gly Gly His Arg Ala Ile
    130                 135                 140                 
Trp Val Gln Glu Trp Gln Asp Gln Gln Glu Asp His His Cys
145                 150                 155             


<210> 6776
<211> 160
<212> PRT
<213> Homo sapiens

<400> 6776
Met Met Asn Asn Thr Asp Phe Leu Met Leu Asn Asn Pro Trp Asn Lys
 1               5                  10                  15      
Leu Cys Leu Val Ser Met Asp Phe Cys Phe Pro Leu Asp Phe Val Ser
            20                  25                  30          
Asn Leu Phe Trp Ile Phe Ala Ser Lys Phe Ile Ile Val Thr Gly Gln
        35                  40                  45              
Ile Lys Ala Asp Phe Lys Arg Thr Ser Trp Glu Ala Lys Ala Glu Gly
    50                  55                  60                  
Ser Leu Glu Pro Gly Arg Leu Lys Leu Gln Leu Ala Ser Ile Val Pro
65                  70                  75                  80  
Leu Tyr Ser Ser Leu Val Thr Ala Gly Pro Ala Ser Lys Ile Ile Ile
                85                  90                  95      
Leu Lys Arg Thr Ser Leu Pro Thr Val Ser Pro Ser Asn Glu Arg Ala
            100                 105                 110         
Tyr Leu Leu Pro Val Ser Phe Thr Asp Leu Ala His Val Phe Tyr Leu
        115                 120                 125             
Ser Tyr Phe Ser Ile Asn Ala Lys Ser Asn Ser Phe Ser Leu Asp Ile
    130                 135                 140                 
Ile Ile Ala Leu Gly Ile Pro His Asn Thr Gln Ala His Phe Asn His
145                 150                 155                 160 


<210> 6777
<211> 61
<212> PRT
<213> Homo sapiens

<400> 6777
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala
 1               5                  10                  15      
Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser
            20                  25                  30          
Cys Cys Ser Cys Cys Pro Met Ser Cys Ala Lys Cys Ala Gln Gly Cys
        35                  40                  45              
Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala
    50                  55                  60      


<210> 6778
<211> 61
<212> PRT
<213> Homo sapiens

<400> 6778
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala
 1               5                  10                  15      
Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser
            20                  25                  30          
Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys
        35                  40                  45              
Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser Cys Cys Ala
    50                  55                  60      


<210> 6779
<211> 470
<212> PRT
<213> Homo sapiens

<400> 6779
Met Gly Lys Pro Trp Leu Arg Ala Leu Gln Leu Leu Leu Leu Leu Gly
 1               5                  10                  15      
Ala Ser Trp Ala Arg Ala Gly Ala Pro Arg Cys Thr Tyr Thr Phe Val
            20                  25                  30          
Leu Pro Pro Gln Lys Phe Thr Gly Ala Val Cys Trp Ser Gly Pro Ala
        35                  40                  45              
Ser Thr Arg Ala Thr Pro Glu Ala Ala Asn Ala Ser Glu Leu Ala Ala
    50                  55                  60                  
Leu Arg Met Arg Val Gly Arg His Glu Glu Leu Leu Arg Glu Leu Gln
65                  70                  75                  80  
Arg Leu Ala Ala Ala Asp Gly Ala Val Ala Gly Glu Val Arg Ala Leu
                85                  90                  95      
Arg Lys Glu Ser Arg Gly Leu Ser Ala Arg Leu Gly Gln Leu Arg Ala
            100                 105                 110         
Gln Leu Gln His Glu Ala Gly Pro Gly Ala Gly Pro Gly Ala Asp Leu
        115                 120                 125             
Gly Ala Glu Pro Ala Ala Ala Leu Ala Leu Leu Gly Glu Arg Val Leu
    130                 135                 140                 
Asn Ala Ser Ala Glu Ala Gln Arg Ala Ala Ala Arg Phe His Gln Leu
145                 150                 155                 160 
Asp Val Lys Phe Arg Glu Leu Ala Gln Leu Val Thr Gln Gln Ser Ser
                165                 170                 175     
Leu Ile Ala Arg Leu Glu Arg Leu Cys Pro Gly Gly Ala Gly Gly Gln
            180                 185                 190         
Gln Gln Val Leu Pro Pro Pro Pro Leu Val Pro Val Val Pro Val Arg
        195                 200                 205             
Leu Val Gly Ser Thr Ser Asp Thr Ser Arg Met Leu Asp Pro Ala Pro
    210                 215                 220                 
Glu Pro Gln Arg Asp Gln Thr Gln Arg Gln Gln Glu Pro Met Ala Ser
225                 230                 235                 240 
Pro Met Pro Ala Gly His Pro Ala Val Pro Thr Lys Pro Val Gly Pro
                245                 250                 255     
Trp Gln Asp Cys Ala Glu Ala Arg Gln Ala Gly His Glu Gln Ser Gly
            260                 265                 270         
Val Tyr Glu Leu Arg Val Gly Arg His Val Val Ser Val Trp Cys Glu
        275                 280                 285             
Gln Gln Leu Glu Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Gln Asp
    290                 295                 300                 
Gly Ser Val Asn Phe Phe Thr Thr Trp Gln His Tyr Lys Ala Gly Phe
305                 310                 315                 320 
Gly Arg Pro Asp Gly Glu Tyr Trp Leu Gly Leu Glu Pro Val Tyr Gln
                325                 330                 335     
Leu Thr Ser Arg Gly Asp His Glu Leu Leu Val Leu Leu Glu Asp Trp
            340                 345                 350         
Gly Gly Arg Gly Ala Arg Ala His Tyr Asp Gly Phe Ser Leu Glu Pro
        355                 360                 365             
Glu Ser Asp His Tyr Arg Leu Arg Leu Gly Gln Tyr His Gly Asp Ala
    370                 375                 380                 
Gly Asp Ser Leu Ser Trp His Asn Asp Lys Pro Phe Ser Thr Val Asp
385                 390                 395                 400 
Arg Asp Arg Asp Ser Tyr Ser Gly Asn Cys Ala Leu Tyr Gln Arg Gly
                405                 410                 415     
Gly Trp Trp Tyr His Ala Cys Ala His Ser Asn Leu Asn Gly Val Trp
            420                 425                 430         
His His Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp Gly Val Tyr Trp
        435                 440                 445             
Ala Glu Phe Arg Gly Gly Ala Tyr Ser Leu Arg Lys Ala Ala Met Leu
    450                 455                 460                 
Ile Arg Pro Leu Lys Leu
465                 470 


<210> 6780
<211> 470
<212> PRT
<213> Homo sapiens

<400> 6780
Met Gly Lys Pro Trp Leu Arg Ala Leu Gln Leu Leu Leu Leu Leu Gly
 1               5                  10                  15      
Ala Ser Trp Ala Arg Ala Gly Ala Pro Arg Cys Thr Tyr Thr Phe Val
            20                  25                  30          
Leu Pro Pro Gln Lys Phe Thr Gly Ala Val Cys Trp Ser Gly Pro Ala
        35                  40                  45              
Ser Thr Arg Ala Thr Pro Glu Ala Ala Asn Ala Ser Glu Leu Ala Ala
    50                  55                  60                  
Leu Arg Met Arg Val Gly Arg His Glu Glu Leu Leu Arg Glu Leu Gln
65                  70                  75                  80  
Arg Leu Ala Ala Ala Asp Gly Ala Val Ala Gly Lys Val Arg Ala Leu
                85                  90                  95      
Arg Lys Glu Ser Arg Gly Leu Ser Ala Arg Leu Gly Gln Leu Arg Ala
            100                 105                 110         
Gln Leu Gln His Glu Ala Gly Pro Gly Ala Gly Pro Gly Ala Asp Leu
        115                 120                 125             
Gly Ala Glu Pro Ala Ala Ala Leu Ala Leu Leu Gly Glu Arg Val Leu
    130                 135                 140                 
Asn Ala Ser Ala Glu Ala Gln Arg Ala Ala Ala Arg Phe His Gln Leu
145                 150                 155                 160 
Asp Val Lys Phe Arg Glu Leu Ala Gln Leu Val Thr Gln Gln Ser Ser
                165                 170                 175     
Leu Ile Ala Arg Leu Glu Arg Leu Cys Pro Gly Gly Ala Gly Gly Gln
            180                 185                 190         
Gln Gln Val Leu Pro Pro Pro Pro Leu Val Pro Val Val Pro Val Arg
        195                 200                 205             
Leu Val Gly Ser Thr Ser Asp Thr Ser Arg Met Leu Asp Pro Ala Pro
    210                 215                 220                 
Glu Pro Gln Arg Asp Gln Thr Gln Arg Gln Gln Glu Pro Met Ala Ser
225                 230                 235                 240 
Pro Met Pro Ala Gly His Pro Ala Val Pro Thr Lys Pro Val Gly Pro
                245                 250                 255     
Trp Gln Asp Cys Ala Glu Ala Arg Gln Ala Gly His Glu Gln Ser Gly
            260                 265                 270         
Val Tyr Glu Leu Arg Val Gly Arg His Val Val Ser Val Trp Cys Glu
        275                 280                 285             
Gln Gln Leu Glu Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Gln Asp
    290                 295                 300                 
Gly Ser Val Asn Phe Phe Thr Thr Trp Gln His Tyr Lys Ala Gly Phe
305                 310                 315                 320 
Gly Arg Pro Asp Gly Glu Tyr Trp Leu Gly Leu Glu Pro Val Tyr Gln
                325                 330                 335     
Leu Thr Ser Arg Gly Asp His Glu Leu Leu Val Leu Leu Glu Asp Trp
            340                 345                 350         
Gly Gly Arg Gly Ala Arg Ala His Tyr Asp Gly Phe Ser Leu Glu Pro
        355                 360                 365             
Glu Ser Asp His Tyr Arg Leu Arg Leu Gly Gln Tyr His Gly Asp Ala
    370                 375                 380                 
Gly Asp Ser Leu Ser Trp His Asn Asp Lys Pro Phe Ser Thr Val Asp
385                 390                 395                 400 
Arg Asp Arg Asp Ser Tyr Ser Gly Asn Cys Ala Leu Tyr Gln Arg Gly
                405                 410                 415     
Gly Trp Trp Tyr His Ala Cys Ala His Ser Asn Leu Asn Gly Val Trp
            420                 425                 430         
His His Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp Gly Val Tyr Trp
        435                 440                 445             
Ala Glu Phe Arg Gly Gly Ala Tyr Ser Leu Arg Lys Ala Ala Met Leu
    450                 455                 460                 
Ile Arg Pro Leu Lys Leu
465                 470 


<210> 6781
<211> 336
<212> PRT
<213> Homo sapiens

<400> 6781
Met Lys Thr Leu Met Arg His Gly Leu Ala Val Cys Leu Ala Leu Thr
 1               5                  10                  15      
Thr Met Cys Thr Ser Leu Leu Leu Val Tyr Ser Ser Leu Gly Gly Gln
            20                  25                  30          
Lys Glu Arg Pro Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        35                  40                  45              
Gln Ala Ser Ala Thr Gly Ser Ser Gln Pro Ala Ala Glu Ser Ser Thr
    50                  55                  60                  
Gln Gln Arg Pro Gly Val Pro Ala Gly Pro Arg Pro Leu Asp Gly Tyr
65                  70                  75                  80  
Leu Gly Val Ala Asp His Lys Pro Leu Lys Met His Cys Arg Asp Cys
                85                  90                  95      
Ala Leu Val Thr Ser Ser Gly His Leu Leu His Ser Arg Gln Gly Ser
            100                 105                 110         
Gln Ile Asp Gln Thr Glu Cys Val Ile Arg Met Asn Asp Ala Pro Thr
        115                 120                 125             
Arg Gly Tyr Gly Arg Asp Val Gly Asn Arg Thr Ser Leu Arg Val Ile
    130                 135                 140                 
Ala His Ser Ser Ile Gln Arg Ile Leu Arg Asn Arg His Asp Leu Leu
145                 150                 155                 160 
Asn Val Ser Gln Gly Thr Val Phe Ile Phe Trp Gly Pro Ser Ser Tyr
                165                 170                 175     
Met Arg Arg Asp Gly Lys Gly Gln Val Tyr Asn Asn Leu His Leu Leu
            180                 185                 190         
Ser Gln Val Leu Pro Arg Leu Lys Ala Phe Met Ile Thr Arg His Lys
        195                 200                 205             
Met Leu Gln Phe Asp Glu Leu Phe Lys Gln Glu Thr Gly Lys Asp Arg
    210                 215                 220                 
Lys Ile Ser Asn Thr Trp Leu Ser Thr Gly Trp Phe Thr Met Thr Ile
225                 230                 235                 240 
Ala Leu Glu Leu Cys Asp Arg Ile Asn Val Tyr Gly Met Val Pro Pro
                245                 250                 255     
Asp Phe Cys Arg Asp Pro Asn His Pro Ser Val Pro Tyr His Tyr Tyr
            260                 265                 270         
Glu Pro Phe Gly Pro Asp Glu Cys Thr Met Tyr Leu Ser His Glu Arg
        275                 280                 285             
Gly Arg Lys Gly Ser His His Arg Phe Ile Thr Glu Lys Arg Val Phe
    290                 295                 300                 
Lys Asn Trp Ala Arg Thr Phe Asn Ile His Phe Phe Gln Pro Asp Trp
305                 310                 315                 320 
Lys Pro Glu Ser Leu Ala Ile Asn His Pro Glu Asn Lys Pro Val Phe
                325                 330                 335     


<210> 6782
<211> 661
<212> PRT
<213> Homo sapiens

<400> 6782
Met Ala Phe Asp Val Ser Cys Phe Phe Trp Val Val Leu Phe Ser Ala
 1               5                  10                  15      
Gly Cys Lys Val Ile Thr Ser Trp Asp Gln Met Cys Ile Glu Lys Glu
            20                  25                  30          
Ala Asn Lys Thr Tyr Asn Cys Glu Asn Leu Gly Leu Ser Glu Ile Pro
        35                  40                  45              
Asp Thr Leu Pro Asn Thr Thr Glu Phe Leu Glu Phe Ser Phe Asn Phe
    50                  55                  60                  
Leu Pro Thr Ile His Asn Arg Thr Phe Ser Arg Leu Met Asn Leu Thr
65                  70                  75                  80  
Phe Leu Asp Leu Thr Arg Cys Gln Ile Asn Trp Ile His Glu Asp Thr
                85                  90                  95      
Phe Gln Ser His His Gln Leu Ser Thr Leu Val Leu Thr Gly Asn Pro
            100                 105                 110         
Leu Ile Phe Met Ala Glu Thr Ser Leu Asn Gly Pro Lys Ser Leu Lys
        115                 120                 125             
His Leu Phe Leu Ile Gln Thr Gly Ile Ser Asn Leu Glu Phe Ile Pro
    130                 135                 140                 
Val His Asn Leu Glu Asn Leu Glu Ser Leu Tyr Leu Gly Ser Asn His
145                 150                 155                 160 
Ile Ser Ser Ile Lys Phe Pro Lys Asp Phe Pro Ala Arg Asn Leu Lys
                165                 170                 175     
Val Leu Asp Phe Gln Asn Asn Ala Ile His Tyr Ile Ser Arg Glu Asp
            180                 185                 190         
Met Arg Ser Leu Glu Gln Ala Ile Asn Leu Ser Leu Asn Phe Asn Gly
        195                 200                 205             
Asn Asn Val Lys Gly Ile Glu Leu Gly Ala Phe Asp Ser Thr Val Phe
    210                 215                 220                 
Gln Ser Leu Asn Phe Gly Gly Thr Pro Asn Leu Ser Val Ile Phe Asn
225                 230                 235                 240 
Gly Leu Gln Asn Ser Thr Thr Gln Ser Leu Trp Leu Gly Thr Phe Glu
                245                 250                 255     
Asp Ile Asp Asp Glu Asp Ile Ser Ser Ala Met Leu Lys Gly Leu Cys
            260                 265                 270         
Glu Met Ser Val Glu Ser Leu Asn Leu Gln Glu His Arg Phe Ser Asp
        275                 280                 285             
Ile Ser Ser Thr Thr Phe Gln Cys Phe Thr Gln Leu Gln Glu Leu Asp
    290                 295                 300                 
Leu Thr Ala Thr His Leu Lys Gly Leu Pro Ser Gly Met Lys Gly Leu
305                 310                 315                 320 
Asn Leu Leu Lys Lys Leu Val Leu Ser Val Asn His Phe Asp Gln Leu
                325                 330                 335     
Cys Gln Ile Ser Ala Ala Asn Phe Pro Ser Leu Thr His Leu Tyr Ile
            340                 345                 350         
Arg Gly Asn Val Lys Lys Leu His Leu Gly Val Gly Cys Leu Glu Lys
        355                 360                 365             
Leu Gly Asn Leu Gln Thr Leu Asp Leu Ser His Asn Asp Ile Glu Ala
    370                 375                 380                 
Ser Asp Cys Cys Ser Leu Gln Leu Lys Asn Leu Ser His Leu Gln Thr
385                 390                 395                 400 
Leu Asn Leu Ser His Asn Glu Pro Leu Gly Leu Gln Ser Gln Ala Phe
                405                 410                 415     
Lys Glu Cys Pro Gln Leu Glu Leu Leu Asp Leu Ala Phe Thr Arg Leu
            420                 425                 430         
His Ile Asn Ala Pro Gln Ser Pro Phe Gln Asn Leu His Phe Leu Gln
        435                 440                 445             
Val Leu Asn Leu Thr Tyr Cys Phe Leu Asp Thr Ser Asn Gln His Leu
    450                 455                 460                 
Leu Ala Gly Leu Pro Val Leu Arg His Leu Asn Leu Lys Gly Asn His
465                 470                 475                 480 
Phe Gln Asp Gly Thr Ile Thr Lys Thr Asn Leu Leu Gln Thr Val Gly
                485                 490                 495     
Ser Leu Glu Val Leu Ile Leu Ser Ser Cys Gly Leu Leu Ser Ile Asp
            500                 505                 510         
Gln Gln Ala Phe His Ser Leu Gly Lys Met Ser His Val Asp Leu Ser
        515                 520                 525             
His Asn Ser Leu Thr Cys Asp Ser Ile Asp Ser Leu Ser His Leu Lys
    530                 535                 540                 
Gly Ile Tyr Leu Asn Leu Ala Ala Asn Ser Ile Asn Ile Ile Ser Pro
545                 550                 555                 560 
Arg Leu Leu Pro Ile Leu Ser Gln Gln Ser Thr Ile Asn Leu Ser His
                565                 570                 575     
Asn Pro Leu Asp Cys Thr Cys Ser Asn Ile His Phe Leu Thr Trp Tyr
            580                 585                 590         
Lys Glu Asn Leu His Lys Leu Glu Gly Ser Glu Glu Thr Thr Cys Ala
        595                 600                 605             
Asn Pro Pro Ser Leu Arg Gly Val Lys Leu Ser Asp Val Lys Leu Ser
    610                 615                 620                 
Cys Gly Ile Thr Ala Ile Gly Ile Phe Phe Leu Ile Val Phe Leu Leu
625                 630                 635                 640 
Leu Leu Ala Ile Leu Leu Phe Phe Ala Val Lys Tyr Leu Leu Arg Trp
                645                 650                 655     
Lys Tyr Gln His Ile
            660     


<210> 6783
<211> 1848
<212> PRT
<213> Homo sapiens

<400> 6783
Met Arg Arg Gln Trp Gly Ala Leu Leu Leu Gly Ala Leu Leu Cys Ala
 1               5                  10                  15      
His Val Leu Pro Thr Cys Ser Pro Leu Asp Phe His Cys Asp Asn Gly
            20                  25                  30          
Lys Cys Ile Arg Arg Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Glu
        35                  40                  45              
Asp Asp Ser Asp Glu Gln Asp Cys Pro Pro Arg Glu Cys Glu Glu Asp
    50                  55                  60                  
Glu Phe Pro Cys Gln Asn Gly Tyr Cys Ile Arg Ser Leu Trp His Cys
65                  70                  75                  80  
Asp Gly Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Gln Cys Asp Met
                85                  90                  95      
Arg Lys Cys Ser Asp Lys Glu Phe Arg Cys Ser Asp Gly Ser Cys Ile
            100                 105                 110         
Ala Glu His Trp Tyr Cys Asp Gly Asp Thr Asp Cys Lys Asp Gly Ser
        115                 120                 125             
Asp Glu Glu Asn Cys Pro Ser Ala Val Pro Ala Pro Pro Cys Asn Leu
    130                 135                 140                 
Glu Glu Phe Gln Cys Ala Tyr Gly Arg Cys Ile Leu Asp Ile Tyr His
145                 150                 155                 160 
Cys Asp Gly Asp Asp Asp Cys Gly Asp Trp Ser Asp Glu Ser Asp Cys
                165                 170                 175     
Cys Glu Tyr Ser Gly Gln Leu Gly Ala Ser His Gln Pro Cys Arg Ser
            180                 185                 190         
Gly Glu Phe Met Cys Asp Ser Gly Leu Cys Ile Asn Ala Gly Trp Arg
        195                 200                 205             
Cys Asp Gly Asp Ala Asp Cys Asp Asp Gln Ser Asp Glu Arg Asn Cys
    210                 215                 220                 
Lys Gln Phe Arg Cys His Ser Gly Arg Cys Val Arg Leu Ser Trp Arg
225                 230                 235                 240 
Cys Asp Gly Glu Asp Asp Cys Ala Asp Asn Ser Asp Glu Glu Asn Cys
                245                 250                 255     
Glu Asn Thr Gly Ser Pro Gln Cys Ala Leu Asp Gln Phe Leu Cys Trp
            260                 265                 270         
Asn Gly Arg Cys Ile Gly Gln Arg Lys Leu Cys Asn Gly Val Asn Asp
        275                 280                 285             
Cys Gly Asp Asn Ser Asp Glu Ser Pro Gln Gln Asn Cys Arg Pro Arg
    290                 295                 300                 
Thr Gly Glu Glu Asn Cys Asn Val Asn Asn Gly Gly Cys Ala Gln Lys
305                 310                 315                 320 
Cys Gln Met Val Arg Gly Ala Val Gln Cys Thr Cys His Thr Gly Tyr
                325                 330                 335     
Arg Leu Thr Glu Asp Gly His Thr Cys Gln Asp Val Asn Glu Cys Ala
            340                 345                 350         
Glu Glu Gly Tyr Cys Ser Gln Gly Cys Thr Asn Ser Glu Gly Ala Phe
        355                 360                 365             
Gln Cys Trp Cys Glu Thr Gly Tyr Glu Leu Arg Pro Asp Arg Arg Ser
    370                 375                 380                 
Cys Lys Ala Leu Gly Pro Glu Pro Val Leu Leu Phe Ala Asn Arg Ile
385                 390                 395                 400 
Asp Ile Arg Gln Val Leu Pro His Arg Ser Glu Tyr Thr Leu Leu Leu
                405                 410                 415     
Asn Asn Leu Glu Asn Ala Ile Ala Leu Asp Phe His His Arg Arg Glu
            420                 425                 430         
Leu Val Phe Trp Ser Asp Val Thr Leu Asp Arg Ile Leu Arg Ala Asn
        435                 440                 445             
Leu Asn Gly Ser Asn Val Glu Glu Val Val Ser Thr Gly Leu Glu Ser
    450                 455                 460                 
Pro Gly Gly Leu Ala Val Asp Trp Val His Asp Lys Leu Tyr Trp Thr
465                 470                 475                 480 
Asp Ser Gly Thr Ser Arg Ile Glu Val Ala Asn Leu Asp Gly Ala His
                485                 490                 495     
Arg Lys Val Leu Leu Trp Gln Asn Leu Glu Lys Pro Arg Ala Ile Ala
            500                 505                 510         
Leu His Pro Met Glu Gly Thr Ile Tyr Trp Thr Asp Trp Gly Asn Thr
        515                 520                 525             
Pro Arg Ile Glu Ala Ser Ser Met Asp Gly Ser Gly Arg Arg Ile Ile
    530                 535                 540                 
Ala Asp Thr His Leu Phe Trp Pro Asn Gly Leu Thr Ile Asp Tyr Ala
545                 550                 555                 560 
Gly Arg Arg Met Tyr Trp Val Asp Ala Lys His His Val Ile Glu Arg
                565                 570                 575     
Ala Asn Leu Asp Gly Ser His Arg Lys Ala Val Ile Ser Gln Val Phe
            580                 585                 590         
Glu Asp Ser Leu Tyr Trp Thr Asp Trp His Thr Lys Ser Ile Asn Ser
        595                 600                 605             
Ala Asn Lys Phe Thr Gly Lys Asn Gln Glu Ile Ile Arg Asn Lys Leu
    610                 615                 620                 
His Phe Pro Met Asp Ile His Thr Leu His Pro Gln Arg Gln Pro Ala
625                 630                 635                 640 
Gly Lys Asn Arg Cys Gly Asp Asn Asn Gly Gly Cys Thr His Leu Cys
                645                 650                 655     
Leu Pro Ser Gly Gln Asn Tyr Thr Cys Ala Cys Pro Thr Gly Phe Arg
            660                 665                 670         
Lys Ile Ser Ser His Ala Cys Ala Gln Ser Leu Asp Lys Phe Leu Leu
        675                 680                 685             
Phe Ala Arg Arg Met Asp Ile Arg Arg Ile Ser Phe Asp Thr Glu Asp
    690                 695                 700                 
Leu Ser Asp Asp Val Ile Pro Leu Ala Asp Val Arg Ser Ala Val Ala
705                 710                 715                 720 
Leu Asp Trp Asp Ser Arg Asp Asp His Val Tyr Trp Thr Asp Val Ser
                725                 730                 735     
Thr Asp Thr Ile Ser Arg Ala Lys Trp Asp Gly Thr Gly Gln Glu Val
            740                 745                 750         
Val Val Asp Thr Ser Leu Glu Ser Pro Ala Gly Leu Ala Ile Asp Trp
        755                 760                 765             
Val Thr Asn Lys Leu Tyr Trp Thr Asp Ala Gly Thr Asp Arg Ile Glu
    770                 775                 780                 
Val Ala Asn Thr Asp Gly Ser Met Arg Thr Val Leu Ile Trp Glu Asn
785                 790                 795                 800 
Leu Asp Arg Pro Arg Asp Ile Val Val Glu Pro Met Gly Gly Tyr Met
                805                 810                 815     
Tyr Trp Thr Asp Trp Gly Ala Ser Pro Lys Ile Glu Arg Ala Gly Met
            820                 825                 830         
Asp Ala Ser Gly Arg Gln Val Ile Ile Ser Ser Asn Leu Thr Trp Pro
        835                 840                 845             
Asn Gly Leu Ala Ile Asp Tyr Gly Ser Gln Arg Leu Tyr Trp Ala Asp
    850                 855                 860                 
Ala Gly Met Lys Thr Ile Glu Phe Ala Gly Leu Asp Gly Ser Lys Arg
865                 870                 875                 880 
Lys Val Leu Ile Gly Ser Gln Leu Pro His Pro Phe Gly Leu Thr Leu
                885                 890                 895     
Tyr Gly Glu Arg Ile Tyr Trp Thr Asp Trp Gln Thr Lys Ser Ile Gln
            900                 905                 910         
Ser Ala Asp Arg Leu Thr Gly Leu Asp Arg Glu Thr Leu Gln Glu Asn
        915                 920                 925             
Leu Glu Asn Leu Met Asp Ile His Val Phe His Arg Arg Arg Pro Pro
    930                 935                 940                 
Val Ser Thr Pro Cys Ala Met Glu Asn Gly Gly Cys Ser His Leu Cys
945                 950                 955                 960 
Leu Arg Ser Pro Asn Pro Ser Gly Phe Ser Cys Thr Cys Pro Thr Gly
                965                 970                 975     
Ile Asn Leu Leu Ser Asp Gly Lys Thr Cys Ser Pro Gly Met Asn Ser
            980                 985                 990         
Phe Leu Ile Phe Ala Arg Arg Ile Asp Ile Arg Met Val Ser Leu Asp
        995                 1000                1005            
Ile Pro Tyr Phe Ala Asp Val Val Val Pro Ile Asn Ile Thr Met Lys
    1010                1015                1020                
Asn Thr Ile Ala Ile Gly Val Asp Pro Gln Glu Gly Lys Val Tyr Trp
1025                1030                1035                1040
Ser Asp Ser Thr Leu His Arg Ile Ser Arg Ala Asn Leu Asp Gly Ser
                1045                1050                1055    
Gln His Glu Asp Ile Ile Thr Thr Gly Leu Gln Thr Thr Asp Gly Leu
            1060                1065                1070        
Ala Val Asp Ala Ile Gly Arg Lys Val Tyr Trp Thr Asp Thr Gly Thr
        1075                1080                1085            
Asn Arg Ile Glu Val Gly Asn Leu Asp Gly Ser Met Arg Lys Val Leu
    1090                1095                1100                
Val Trp Gln Asn Leu Asp Ser Pro Arg Ala Ile Val Leu Tyr His Glu
1105                1110                1115                1120
Met Gly Phe Met Tyr Trp Thr Asp Trp Gly Glu Asn Ala Lys Leu Glu
                1125                1130                1135    
Arg Ser Gly Met Asp Gly Ser Asp Arg Ala Val Leu Ile Asn Asn Asn
            1140                1145                1150        
Leu Gly Trp Pro Asn Gly Leu Thr Val Asp Lys Ala Ser Ser Gln Leu
        1155                1160                1165            
Leu Trp Ala Asp Ala His Thr Glu Arg Ile Glu Ala Ala Asp Leu Asn
    1170                1175                1180                
Gly Ala Asn Arg His Thr Leu Val Ser Pro Val Gln His Pro Tyr Gly
1185                1190                1195                1200
Leu Thr Leu Leu Asp Ser Tyr Ile Tyr Trp Thr Asp Trp Gln Thr Arg
                1205                1210                1215    
Ser Ile His Arg Ala Asp Lys Gly Thr Gly Ser Asn Val Ile Leu Val
            1220                1225                1230        
Arg Ser Asn Leu Pro Gly Leu Met Asp Met Gln Ala Val Asp Arg Ala
        1235                1240                1245            
Gln Pro Leu Gly Phe Asn Lys Cys Gly Ser Arg Asn Gly Gly Cys Ser
    1250                1255                1260                
His Leu Cys Leu Pro Arg Pro Ser Gly Phe Ser Cys Ala Cys Pro Thr
1265                1270                1275                1280
Gly Ile Gln Leu Lys Gly Asp Gly Lys Thr Cys Asp Pro Ser Pro Glu
                1285                1290                1295    
Thr Tyr Leu Leu Phe Ser Ser Arg Gly Ser Ile Arg Arg Ile Ser Leu
            1300                1305                1310        
Asp Thr Ser Asp His Thr Asp Val His Val Pro Val Pro Glu Leu Asn
        1315                1320                1325            
Asn Val Ile Ser Leu Asp Tyr Asp Ser Val Asp Gly Lys Val Tyr Tyr
    1330                1335                1340                
Thr Asp Val Phe Leu Asp Val Ile Arg Arg Ala Asp Leu Asn Gly Ser
1345                1350                1355                1360
Asn Met Glu Thr Val Ile Gly Arg Gly Leu Lys Thr Thr Asp Gly Leu
                1365                1370                1375    
Ala Val Asp Trp Val Ala Arg Asn Leu Tyr Trp Thr Asp Thr Gly Arg
            1380                1385                1390        
Asn Thr Ile Glu Ala Ser Arg Leu Asp Gly Ser Cys Arg Lys Val Leu
        1395                1400                1405            
Ile Asn Asn Ser Leu Asp Glu Pro Arg Ala Ile Ala Val Phe Pro Arg
    1410                1415                1420                
Lys Gly Tyr Leu Phe Trp Thr Asp Trp Gly His Ile Ala Lys Ile Glu
1425                1430                1435                1440
Arg Ala Asn Leu Asp Gly Ser Glu Arg Lys Val Leu Ile Asn Thr Asp
                1445                1450                1455    
Leu Gly Trp Pro Asn Gly Leu Thr Leu Asp Tyr Asp Thr Arg Arg Ile
            1460                1465                1470        
Tyr Trp Val Asp Ala His Leu Asp Arg Ile Glu Ser Ala Asp Leu Asn
        1475                1480                1485            
Gly Lys Leu Arg Gln Val Leu Val Ser His Val Ser His Pro Phe Ala
    1490                1495                1500                
Leu Thr Gln Gln Asp Arg Trp Ile Tyr Trp Thr Asp Trp Gln Thr Lys
1505                1510                1515                1520
Ser Ile Gln Arg Val Asp Lys Tyr Ser Gly Arg Asn Lys Glu Thr Val
                1525                1530                1535    
Leu Ala Asn Val Glu Gly Leu Met Asp Ile Ile Val Val Ser Pro Gln
            1540                1545                1550        
Arg Gln Thr Gly Thr Asn Ala Cys Gly Val Asn Asn Gly Gly Cys Thr
        1555                1560                1565            
His Leu Cys Phe Ala Arg Ala Ser Asp Phe Val Cys Ala Cys Pro Asp
    1570                1575                1580                
Glu Pro Asp Ser Arg Pro Cys Ser Leu Val Pro Gly Leu Val Pro Pro
1585                1590                1595                1600
Ala Pro Arg Ala Thr Gly Met Ser Glu Lys Ser Pro Val Leu Pro Asn
                1605                1610                1615    
Thr Pro Pro Thr Thr Leu Tyr Ser Ser Thr Thr Arg Thr Arg Thr Ser
            1620                1625                1630        
Leu Glu Glu Val Glu Gly Arg Cys Ser Glu Arg Asp Ala Arg Leu Gly
        1635                1640                1645            
Leu Cys Ala Arg Ser Asn Asp Ala Val Pro Ala Ala Pro Gly Glu Gly
    1650                1655                1660                
Leu His Ile Ser Tyr Ala Ile Gly Gly Leu Leu Ser Ile Leu Leu Ile
1665                1670                1675                1680
Leu Val Val Ile Ala Ala Leu Met Leu Tyr Arg His Lys Lys Ser Lys
                1685                1690                1695    
Phe Thr Asp Pro Gly Met Gly Asn Leu Thr Tyr Ser Asn Pro Ser Tyr
            1700                1705                1710        
Arg Thr Ser Thr Gln Glu Val Lys Ile Glu Ala Ile Pro Lys Pro Ala
        1715                1720                1725            
Met Tyr Asn Gln Leu Cys Tyr Lys Lys Glu Gly Gly Pro Asp His Asn
    1730                1735                1740                
Tyr Thr Lys Glu Lys Ile Lys Ile Val Glu Gly Ile Cys Leu Leu Ser
1745                1750                1755                1760
Gly Asp Asp Ala Glu Trp Asp Asp Leu Lys Gln Leu Arg Ser Ser Arg
                1765                1770                1775    
Gly Gly Leu Leu Arg Asp His Val Cys Met Lys Thr Asp Thr Val Ser
            1780                1785                1790        
Ile Gln Ala Ser Ser Gly Ser Leu Asp Asp Thr Glu Thr Glu Gln Leu
        1795                1800                1805            
Leu Gln Glu Glu Gln Ser Glu Cys Ser Ser Val His Thr Ala Ala Thr
    1810                1815                1820                
Pro Glu Arg Arg Gly Ser Leu Pro Asp Thr Gly Trp Lys His Glu Arg
1825                1830                1835                1840
Lys Leu Ser Ser Glu Ser Gln Val
                1845            


<210> 6784
<211> 455
<212> PRT
<213> Homo sapiens

<400> 6784
Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu
 1               5                  10                  15      
Ala Ala Ser Gly Ile Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn
            20                  25                  30          
Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val
        35                  40                  45              
Ile Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser
    50                  55                  60                  
Glu Glu Tyr Leu Gln Leu Arg Ser Lys Ile His Asp Leu Phe Gln Ser
65                  70                  75                  80  
Phe Asp Asp Thr Pro Leu Gly Thr Ala Ser Leu Ala Gln Val His Lys
                85                  90                  95      
Ala Val Leu His Asp Gly Arg Thr Val Ala Val Lys Val Gln His Pro
            100                 105                 110         
Lys Val Arg Ala Gln Ser Ser Lys Asp Ile Leu Leu Met Glu Val Leu
        115                 120                 125             
Val Leu Ala Val Lys Gln Leu Phe Pro Glu Phe Glu Phe Met Trp Leu
    130                 135                 140                 
Val Asp Glu Ala Lys Lys Asn Leu Pro Leu Glu Leu Asp Phe Leu Asn
145                 150                 155                 160 
Glu Gly Arg Asn Ala Glu Lys Val Ser Gln Met Leu Arg His Phe Asp
                165                 170                 175     
Phe Leu Lys Val Pro Arg Ile His Trp Asp Leu Ser Thr Glu Arg Val
            180                 185                 190         
Leu Leu Met Glu Phe Val Asp Gly Gly Gln Val Asn Asp Arg Asp Tyr
        195                 200                 205             
Met Glu Arg Asn Lys Ile Asp Val Asn Glu Ile Ser Arg His Leu Gly
    210                 215                 220                 
Lys Met Tyr Ser Glu Met Ile Phe Val Asn Gly Phe Val His Cys Asp
225                 230                 235                 240 
Pro His Pro Gly Asn Val Leu Val Arg Lys His Pro Gly Thr Gly Lys
                245                 250                 255     
Ala Glu Ile Val Leu Leu Asp His Gly Leu Tyr Gln Met Leu Thr Glu
            260                 265                 270         
Glu Phe Arg Leu Asn Tyr Cys His Leu Trp Gln Ser Leu Ile Trp Thr
        275                 280                 285             
Asp Met Lys Arg Val Lys Glu Tyr Ser Gln Arg Leu Gly Ala Gly Asp
    290                 295                 300                 
Leu Tyr Pro Leu Phe Ala Cys Met Leu Thr Ala Arg Ser Trp Asp Ser
305                 310                 315                 320 
Val Asn Arg Gly Ile Ser Gln Ala Pro Val Thr Ala Thr Glu Asp Leu
                325                 330                 335     
Glu Ile Arg Asn Asn Ala Ala Asn Tyr Leu Pro Gln Ile Ser His Leu
            340                 345                 350         
Leu Asn His Val Pro Arg Gln Met Leu Leu Ile Leu Lys Thr Asn Asp
        355                 360                 365             
Leu Leu Arg Gly Ile Glu Ala Ala Leu Gly Thr Arg Ala Ser Ala Ser
    370                 375                 380                 
Ser Phe Leu Asn Met Ser Arg Cys Cys Ile Arg Ala Leu Ala Glu His
385                 390                 395                 400 
Lys Lys Lys Asn Thr Cys Ser Phe Phe Arg Arg Thr Gln Ile Ser Phe
                405                 410                 415     
Ser Glu Ala Phe Asn Leu Trp Gln Ile Asn Leu His Glu Leu Ile Leu
            420                 425                 430         
Arg Val Lys Gly Leu Lys Leu Ala Asp Arg Val Leu Ala Leu Ile Cys
        435                 440                 445             
Trp Leu Phe Pro Ala Pro Leu
    450                 455 


<210> 6785
<211> 1465
<212> PRT
<213> Homo sapiens

<400> 6785
Met Leu Leu Ser Pro Ser Leu Leu Leu Leu Leu Leu Leu Gly Gly Ala
 1               5                  10                  15      
Ala Gly Cys Ala Glu Gly Val Ala Ala Ala Leu Thr Pro Glu Arg Leu
            20                  25                  30          
Leu Glu Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu
        35                  40                  45              
Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Gly Arg Thr
    50                  55                  60                  
Gly Ser Lys Gln Ala Asn Lys His Met Leu Trp Lys Trp Val Ser Asn
65                  70                  75                  80  
His Gly Leu Phe Asn Ile Gly Gly Ser Gly Cys Leu Gly Leu Asn Phe
                85                  90                  95      
Ser Ala Pro Glu Gln Pro Leu Ser Leu Tyr Glu Cys Asp Ser Thr Leu
            100                 105                 110         
Val Ser Leu Arg Trp Arg Cys Asn Arg Lys Met Ile Thr Gly Pro Leu
        115                 120                 125             
Gln Tyr Ser Val Gln Val Ala His Asp Asn Thr Val Val Ala Ser Arg
    130                 135                 140                 
Lys Tyr Ile His Lys Trp Ile Ser Tyr Gly Ser Gly Gly Gly Asp Ile
145                 150                 155                 160 
Cys Glu Tyr Leu His Lys Asp Leu His Thr Ile Lys Gly Asn Thr His
                165                 170                 175     
Gly Met Pro Cys Met Phe Pro Phe Gln Tyr Asn His Gln Trp His His
            180                 185                 190         
Glu Cys Thr Arg Glu Gly Arg Glu Asp Asp Leu Leu Trp Cys Ala Thr
        195                 200                 205             
Thr Ser Arg Tyr Glu Arg Asp Glu Lys Trp Gly Phe Cys Pro Asp Pro
    210                 215                 220                 
Thr Ser Ala Glu Val Gly Cys Asp Thr Ile Trp Glu Lys Asp Leu Asn
225                 230                 235                 240 
Ser His Ile Cys Tyr Gln Phe Asn Leu Leu Ser Ser Leu Ser Trp Ser
                245                 250                 255     
Glu Ala His Ser Ser Cys Gln Met Gln Gly Gly Thr Leu Leu Ser Ile
            260                 265                 270         
Thr Asp Glu Thr Glu Glu Asn Phe Ile Arg Glu His Met Ser Ser Lys
        275                 280                 285             
Thr Val Glu Val Trp Val Gly Leu Asn Gln Leu Asp Glu Asp Ala Gly
    290                 295                 300                 
Trp Gln Trp Ser Asp Gly Thr Pro Leu Asn Tyr Leu Asn Trp Ser Pro
305                 310                 315                 320 
Glu Val Asn Phe Glu Pro Phe Val Glu Asp His Cys Gly Thr Phe Ser
                325                 330                 335     
Ser Phe Met Pro Ser Ala Trp Arg Ser Arg Asp Cys Glu Ser Thr Leu
            340                 345                 350         
Pro Tyr Ile Cys Lys Lys Tyr Leu Asn His Ile Asp His Glu Ile Val
        355                 360                 365             
Glu Lys Asp Ala Trp Lys Tyr Tyr Ala Thr His Cys Glu Pro Gly Trp
    370                 375                 380                 
Asn Pro Tyr Asn Arg Asn Cys Tyr Lys Leu Gln Lys Glu Glu Lys Thr
385                 390                 395                 400 
Trp His Glu Ala Leu Arg Ser Cys Gln Ala Asp Asn Ser Ala Leu Ile
                405                 410                 415     
Asp Ile Thr Ser Leu Ala Glu Val Glu Phe Leu Val Thr Leu Leu Gly
            420                 425                 430         
Asp Glu Asn Ala Ser Glu Thr Trp Ile Gly Leu Ser Ser Asn Lys Ile
        435                 440                 445             
Pro Val Ser Phe Glu Trp Ser Asn Asp Ser Ser Val Ile Phe Thr Asn
    450                 455                 460                 
Trp His Thr Leu Glu Pro His Ile Phe Pro Asn Arg Ser Gln Leu Cys
465                 470                 475                 480 
Val Ser Ala Glu Gln Ser Glu Gly His Trp Lys Val Lys Asn Cys Glu
                485                 490                 495     
Glu Arg Leu Phe Tyr Ile Cys Lys Lys Ala Gly His Val Leu Ser Asp
            500                 505                 510         
Ala Glu Ser Gly Cys Gln Glu Gly Trp Glu Glu Thr Cys Gly Phe Cys
        515                 520                 525             
Tyr Lys Ile Asp Thr Val Leu Arg Ser Phe Asp Gln Ala Ser Ser Gly
    530                 535                 540                 
Tyr Tyr Cys Pro Pro Ala Leu Val Thr Ile Thr Asn Arg Phe Glu Gln
545                 550                 555                 560 
Ala Phe Ile Thr Ser Leu Ile Ser Ser Val Val Lys Met Lys Asp Ser
                565                 570                 575     
Tyr Phe Trp Ile Ala Leu Gln Asp Gln Asn Asp Thr Gly Glu Tyr Thr
            580                 585                 590         
Trp Lys Pro Val Gly Gln Lys Pro Glu Pro Val Gln Tyr Thr His Trp
        595                 600                 605             
Asn Thr His Gln Pro Arg Tyr Ser Gly Gly Cys Val Ala Met Arg Gly
    610                 615                 620                 
Arg His Pro Leu Gly Arg Trp Glu Val Lys His Cys Arg His Phe Lys
625                 630                 635                 640 
Ala Met Ser Leu Cys Lys Gln Pro Val Glu Asn Gln Glu Lys Ala Glu
                645                 650                 655     
Tyr Glu Glu Arg Trp Pro Phe His Pro Cys Tyr Leu Asp Trp Glu Ser
            660                 665                 670         
Glu Pro Gly Leu Ala Ser Cys Phe Lys Val Phe His Ser Glu Lys Val
        675                 680                 685             
Leu Met Lys Arg Thr Trp Arg Glu Ala Glu Ala Phe Cys Glu Glu Phe
    690                 695                 700                 
Gly Ala His Leu Ala Ser Phe Ala His Ile Glu Glu Glu Asn Phe Val
705                 710                 715                 720 
Asn Glu Leu Leu His Pro Lys Phe Asn Trp Thr Glu Glu Arg Gln Phe
                725                 730                 735     
Trp Ile Gly Phe Asn Lys Arg Asn Pro Leu Asn Ala Gly Ser Trp Glu
            740                 745                 750         
Trp Ser Asp Arg Thr Pro Val Val Ser Ser Phe Leu Asp Asn Thr Tyr
        755                 760                 765             
Phe Gly Glu Asp Ala Arg Asn Cys Ala Val Tyr Lys Pro Asn Lys Thr
    770                 775                 780                 
Leu Leu Pro Leu His Cys Gly Ser Lys Arg Glu Trp Ile Cys Lys Ile
785                 790                 795                 800 
Pro Arg Asp Val Lys Pro Lys Ile Pro Phe Trp Tyr Gln Tyr Asp Val
                805                 810                 815     
Pro Trp Leu Phe Tyr Gln Asp Ala Glu Tyr Leu Phe His Thr Phe Ala
            820                 825                 830         
Ser Glu Trp Leu Asn Phe Glu Phe Val Cys Ser Trp Leu His Ser Asp
        835                 840                 845             
Leu Leu Thr Ile His Ser Ala His Glu Gln Glu Phe Ile His Ser Lys
    850                 855                 860                 
Ile Lys Ala Leu Ser Lys Tyr Gly Ala Ser Trp Trp Ile Gly Leu Gln
865                 870                 875                 880 
Glu Glu Arg Ala Asn Asp Glu Phe Arg Trp Arg Asp Gly Thr Pro Val
                885                 890                 895     
Ile Tyr Gln Asn Trp Asp Thr Gly Arg Glu Arg Thr Val Asn Asn Gln
            900                 905                 910         
Ser Gln Arg Cys Gly Phe Ile Ser Ser Ile Thr Gly Leu Trp Gly Ser
        915                 920                 925             
Glu Glu Cys Ser Val Ser Met Pro Ser Ile Cys Lys Arg Lys Lys Val
    930                 935                 940                 
Trp Leu Ile Glu Lys Lys Lys Asp Thr Pro Lys Gln His Gly Thr Cys
945                 950                 955                 960 
Pro Lys Gly Trp Leu Tyr Phe Asn Tyr Lys Cys Leu Leu Leu Asn Ile
                965                 970                 975     
Pro Lys Asp Pro Ser Ser Trp Lys Asn Trp Thr His Ala Gln His Phe
            980                 985                 990         
Cys Ala Glu Glu Gly Gly Thr Leu Val Ala Ile Glu Ser Glu Val Glu
        995                 1000                1005            
Gln Ala Phe Ile Thr Met Asn Leu Phe Gly Gln Thr Thr Ser Val Trp
    1010                1015                1020                
Ile Gly Leu Gln Asn Asp Asp Tyr Glu Thr Trp Leu Asn Gly Lys Pro
1025                1030                1035                1040
Val Val Tyr Ser Asn Trp Ser Pro Phe Asp Ile Ile Asn Ile Pro Ser
                1045                1050                1055    
His Asn Thr Thr Glu Val Gln Lys His Ile Pro Leu Cys Ala Leu Leu
            1060                1065                1070        
Ser Ser Asn Pro Asn Phe His Phe Thr Gly Lys Trp Tyr Phe Glu Asp
        1075                1080                1085            
Cys Gly Lys Glu Gly Tyr Gly Phe Val Cys Glu Lys Met Gln Asp Thr
    1090                1095                1100                
Ser Gly His Gly Val Asn Thr Ser Asp Met Tyr Pro Met Pro Asn Thr
1105                1110                1115                1120
Leu Glu Tyr Gly Asn Arg Thr Tyr Lys Ile Ile Asn Ala Asn Met Thr
                1125                1130                1135    
Trp Tyr Ala Ala Ile Lys Thr Cys Leu Met His Lys Ala Gln Leu Val
            1140                1145                1150        
Ser Ile Thr Asp Gln Tyr His Gln Ser Phe Leu Thr Val Val Leu Asn
        1155                1160                1165            
Arg Leu Gly Tyr Ala His Trp Ile Gly Leu Phe Thr Thr Asp Asn Gly
    1170                1175                1180                
Leu Asn Phe Asp Trp Ser Asp Gly Thr Lys Ser Ser Phe Thr Phe Trp
1185                1190                1195                1200
Lys Asp Glu Glu Ser Ser Leu Leu Gly Asp Cys Val Phe Ala Asp Ser
                1205                1210                1215    
Asn Gly Arg Trp His Ser Thr Ala Cys Asp Ser Phe Leu Gln Gly Ala
            1220                1225                1230        
Ile Cys His Val Pro Pro Glu Thr Arg Gln Ser Glu His Pro Glu Leu
        1235                1240                1245            
Cys Ser Glu Thr Ser Ile Pro Trp Ile Lys Phe Lys Ser Asn Cys Tyr
    1250                1255                1260                
Lys Phe Ser Thr Val Leu Asp Ser Met Ser Phe Glu Ala Ala His Glu
1265                1270                1275                1280
Phe Cys Lys Lys Glu Gly Ser Asn Leu Leu Thr Ile Lys Asp Glu Ala
                1285                1290                1295    
Glu Asn Ala Phe Leu Leu Glu Glu Leu Phe Ala Phe Gly Ser Ser Val
            1300                1305                1310        
Gln Met Val Trp Leu Asn Ala Gln Phe Asp Gly Asn Asn Glu Thr Ile
        1315                1320                1325            
Lys Trp Phe Asp Gly Thr Pro Thr Asp Gln Ser Asn Trp Gly Ile Arg
    1330                1335                1340                
Lys Pro Asp Thr Asp Tyr Phe Lys Pro His His Cys Val Ala Leu Arg
1345                1350                1355                1360
Ile Pro Glu Gly Leu Trp Gln Leu Ser Pro Cys Gln Glu Lys Lys Gly
                1365                1370                1375    
Phe Ile Cys Lys Met Glu Ala Asp Ile His Thr Ala Glu Ala Leu Pro
            1380                1385                1390        
Glu Lys Gly Pro Ser His Ser Ile Ile Pro Leu Ala Val Val Leu Thr
        1395                1400                1405            
Leu Ile Val Ile Val Ala Ile Cys Thr Leu Ser Phe Cys Ile Tyr Lys
    1410                1415                1420                
His Asn Gly Gly Phe Phe Arg Arg Leu Ala Gly Phe Arg Asn Pro Tyr
1425                1430                1435                1440
Tyr Pro Ala Thr Asn Phe Ser Thr Val Tyr Leu Glu Glu Asn Ile Leu
                1445                1450                1455    
Ile Ser Asp Leu Glu Lys Ser Asp Gln
            1460                1465


<210> 6786
<211> 3075
<212> PRT
<213> Homo sapiens

<400> 6786
Met Arg Gly Gly Val Leu Leu Val Leu Leu Leu Cys Val Ala Ala Gln
 1               5                  10                  15      
Cys Arg Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Ser Asn
            20                  25                  30          
Ala His Ile Ser Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met
        35                  40                  45              
Phe Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg Asn Pro
    50                  55                  60                  
Gln Cys Arg Ile Cys Asp Gly Asn Ser Ala Asn Pro Arg Glu Arg His
65                  70                  75                  80  
Pro Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro
                85                  90                  95      
Ser Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Ile Thr Leu Asp
            100                 105                 110         
Leu Arg Gln Val Phe Gln Val Ala Tyr Val Ile Ile Lys Ala Ala Asn
        115                 120                 125             
Ala Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Gly Thr
    130                 135                 140                 
Thr Phe Ser Pro Trp Gln Tyr Tyr Ala Val Ser Asp Ser Glu Cys Leu
145                 150                 155                 160 
Ser Arg Tyr Asn Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala
                165                 170                 175     
Asp Asp Glu Val Ile Cys Thr Ser Tyr Tyr Ser Arg Leu Val Pro Leu
            180                 185                 190         
Glu His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala
        195                 200                 205             
Asp Asp Leu Ser Pro Lys Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile
    210                 215                 220                 
Arg Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr
225                 230                 235                 240 
Leu Ser His Arg Glu Pro Lys Glu Leu Asp Pro Ile Val Thr Arg Arg
                245                 250                 255     
Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys
            260                 265                 270         
Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Thr Thr Lys Lys Leu
        275                 280                 285             
Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asn Arg Cys
    290                 295                 300                 
Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly Thr Val Ser Ser
305                 310                 315                 320 
Gly Asn Thr Cys Glu Ala Cys Asn Cys His Asn Lys Ala Lys Asp Cys
                325                 330                 335     
Tyr Tyr Asp Glu Ser Val Ala Lys Gln Lys Lys Ser Leu Asn Thr Ala
            340                 345                 350         
Gly Gln Phe Arg Gly Gly Gly Val Cys Ile Asn Cys Leu Gln Asn Thr
        355                 360                 365             
Met Gly Ile Asn Cys Glu Thr Cys Ile Asp Gly Tyr Tyr Arg Pro His
    370                 375                 380                 
Lys Val Ser Pro Tyr Glu Asp Glu Pro Cys Arg Pro Cys Asn Cys Asp
385                 390                 395                 400 
Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys Asp Asp Leu His Ser
                405                 410                 415     
Asp Leu His Asn Gly Lys Gln Pro Gly Gln Cys Pro Cys Lys Glu Gly
            420                 425                 430         
Tyr Thr Gly Glu Lys Cys Asp Arg Cys Gln Leu Gly Tyr Lys Asp Tyr
        435                 440                 445             
Pro Thr Cys Val Ser Cys Gly Cys Asn Pro Val Gly Ser Ala Ser Asp
    450                 455                 460                 
Glu Pro Cys Thr Gly Pro Cys Val Cys Lys Glu Asn Val Glu Gly Lys
465                 470                 475                 480 
Ala Cys Asp Arg Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Lys Asn
                485                 490                 495     
Pro Arg Gly Cys Ser Glu Cys Phe Cys Phe Gly Val Ser Asp Val Cys
            500                 505                 510         
Ser Ser Leu Ser Trp Pro Val Gly Gln Val Asn Ser Met Ser Gly Trp
        515                 520                 525             
Leu Val Thr Asp Leu Ile Ser Pro Arg Lys Ile Pro Ser Gln Gln Asp
    530                 535                 540                 
Ala Leu Gly Gly Arg His Gln Val Ser Ile Asn Asn Thr Ala Val Met
545                 550                 555                 560 
Gln Arg Leu Ala Pro Lys Tyr Tyr Trp Ala Ala Pro Glu Ala Tyr Leu
                565                 570                 575     
Gly Asn Lys Leu Thr Ala Phe Gly Gly Phe Leu Lys Tyr Thr Val Ser
            580                 585                 590         
Tyr Asp Ile Pro Val Glu Thr Val Asp Ser Asn Leu Met Ser His Ala
        595                 600                 605             
Asp Val Ile Ile Lys Gly Asn Gly Leu Thr Leu Ser Thr Gln Ala Glu
    610                 615                 620                 
Gly Leu Ser Leu Gln Pro Tyr Glu Glu Tyr Leu Asn Val Val Arg Leu
625                 630                 635                 640 
Val Pro Glu Asn Phe Gln Asp Phe His Ser Lys Arg Gln Ile Asp Arg
                645                 650                 655     
Asp Gln Leu Met Thr Val Leu Ala Asn Val Thr His Leu Leu Ile Arg
            660                 665                 670         
Ala Thr Tyr Asn Ser Ala Lys Met Ala Leu Tyr Arg Leu Glu Ser Val
        675                 680                 685             
Ser Leu Asp Ile Ala Ser Ser Asn Ala Ile Asp Leu Val Val Ala Ala
    690                 695                 700                 
Asp Val Glu His Cys Glu Cys Pro Gln Gly Tyr Thr Gly Thr Ser Cys
705                 710                 715                 720 
Glu Ser Cys Leu Ser Gly Tyr Tyr Arg Val Asp Gly Ile Leu Phe Gly
                725                 730                 735     
Gly Ile Cys Gln Pro Cys Glu Cys His Gly His Ala Ala Glu Cys Asn
            740                 745                 750         
Val His Gly Val Cys Ile Ala Cys Ala His Asn Thr Thr Gly Val His
        755                 760                 765             
Cys Glu Gln Cys Leu Pro Gly Phe Tyr Gly Glu Pro Ser Arg Gly Thr
    770                 775                 780                 
Pro Gly Asp Cys Gln Pro Cys Ala Cys Pro Leu Thr Ile Ala Ser Asn
785                 790                 795                 800 
Asn Phe Ser Pro Thr Cys His Leu Asn Asp Gly Asp Glu Val Val Cys
                805                 810                 815     
Asp Trp Cys Ala Pro Gly Tyr Ser Gly Ala Trp Cys Glu Arg Cys Ala
            820                 825                 830         
Asp Gly Tyr Tyr Gly Asn Pro Thr Val Pro Gly Glu Ser Cys Val Pro
        835                 840                 845             
Cys Asp Cys Ser Gly Asn Val Asp Pro Ser Glu Ala Gly His Cys Asp
    850                 855                 860                 
Ser Val Thr Gly Glu Cys Leu Lys Cys Leu Gly Asn Thr Asp Gly Ala
865                 870                 875                 880 
His Cys Glu Arg Cys Ala Asp Gly Phe Tyr Gly Asp Ala Val Thr Ala
                885                 890                 895     
Lys Asn Cys Arg Ala Cys Glu Cys His Val Lys Gly Ser His Ser Ala
            900                 905                 910         
Val Cys His Leu Glu Thr Gly Leu Cys Asp Cys Lys Pro Asn Val Thr
        915                 920                 925             
Gly Gln Gln Cys Asp Gln Cys Leu His Gly Tyr Tyr Gly Leu Asp Ser
    930                 935                 940                 
Gly His Gly Cys Arg Pro Cys Asn Cys Ser Val Ala Gly Ser Val Ser
945                 950                 955                 960 
Asp Gly Cys Thr Asp Glu Gly Gln Cys His Cys Val Pro Gly Val Ala
                965                 970                 975     
Gly Lys Arg Cys Asp Arg Cys Ala His Gly Phe Tyr Ala Tyr Gln Asp
            980                 985                 990         
Gly Ser Cys Thr Pro Cys Asp Cys Pro His Thr Gln Asn Thr Cys Asp
        995                 1000                1005            
Pro Glu Thr Gly Glu Cys Val Cys Pro Pro His Thr Gln Gly Gly Lys
    1010                1015                1020                
Cys Glu Glu Cys Glu Asp Gly His Trp Gly Tyr Asp Ala Glu Val Gly
1025                1030                1035                1040
Cys Gln Ala Cys Asn Cys Ser Leu Val Gly Ser Thr His His Arg Cys
                1045                1050                1055    
Asp Val Val Thr Gly His Cys Gln Cys Lys Ser Lys Phe Gly Gly Arg
            1060                1065                1070        
Ala Cys Asp Gln Cys Ser Leu Gly Tyr Arg Asp Phe Pro Asp Cys Val
        1075                1080                1085            
Pro Cys Asp Cys Asp Leu Arg Gly Thr Ser Gly Asp Ala Cys Asn Leu
    1090                1095                1100                
Glu Gln Gly Leu Cys Gly Cys Val Glu Glu Thr Gly Ala Cys Pro Cys
1105                1110                1115                1120
Lys Glu Asn Val Phe Gly Pro Gln Cys Asn Glu Cys Arg Glu Gly Thr
                1125                1130                1135    
Phe Ala Leu Arg Ala Asp Asn Pro Leu Gly Cys Ser Pro Cys Phe Cys
            1140                1145                1150        
Ser Gly Leu Ser His Leu Cys Ser Glu Leu Glu Asp Tyr Val Arg Thr
        1155                1160                1165            
Pro Val Thr Leu Gly Ser Asp Gln Pro Leu Leu Arg Val Val Ser Gln
    1170                1175                1180                
Ser Asn Leu Arg Gly Thr Thr Glu Gly Val Tyr Tyr Gln Ala Pro Asp
1185                1190                1195                1200
Phe Leu Leu Asp Ala Ala Thr Val Arg Gln His Ile Arg Ala Glu Pro
                1205                1210                1215    
Phe Tyr Trp Arg Leu Pro Gln Gln Phe Gln Gly Asp Gln Leu Met Ala
            1220                1225                1230        
Tyr Gly Gly Lys Leu Lys Tyr Ser Val Ala Phe Tyr Ser Leu Asp Gly
        1235                1240                1245            
Val Gly Thr Ser Asn Phe Glu Pro Gln Val Leu Ile Lys Gly Gly Arg
    1250                1255                1260                
Ile Arg Lys Gln Val Ile Tyr Met Asp Ala Pro Ala Pro Glu Asn Gly
1265                1270                1275                1280
Val Arg Gln Glu Gln Glu Val Ala Met Arg Glu Asn Phe Trp Lys Tyr
                1285                1290                1295    
Phe Asn Ser Val Ser Glu Lys Pro Val Thr Arg Glu Asp Phe Met Ser
            1300                1305                1310        
Val Leu Ser Asp Ile Glu Tyr Ile Leu Ile Lys Ala Ser Tyr Gly Gln
        1315                1320                1325            
Gly Leu Gln Gln Ser Arg Ile Ser Asp Ile Ser Val Glu Val Gly Arg
    1330                1335                1340                
Lys Ala Glu Lys Leu His Pro Glu Glu Glu Val Ala Ser Leu Leu Glu
1345                1350                1355                1360
Asn Cys Val Cys Pro Pro Gly Thr Val Gly Phe Ser Cys Gln Asp Cys
                1365                1370                1375    
Ala Pro Gly Tyr His Arg Gly Lys Leu Pro Ala Gly Ser Asp Arg Gly
            1380                1385                1390        
Pro Arg Pro Leu Val Ala Pro Cys Val Pro Cys Ser Cys Asn Asn His
        1395                1400                1405            
Ser Asp Thr Cys Asp Pro Asn Thr Gly Lys Cys Leu Asn Cys Gly Asp
    1410                1415                1420                
Asn Thr Ala Gly Asp His Cys Asp Val Cys Thr Ser Gly Tyr Tyr Gly
1425                1430                1435                1440
Lys Val Thr Gly Ser Ala Ser Asp Cys Ala Leu Cys Ala Cys Pro His
                1445                1450                1455    
Ser Pro Pro Ala Ser Phe Ser Pro Thr Cys Val Leu Glu Gly Asp His
            1460                1465                1470        
Asp Phe Arg Cys Asp Ala Cys Leu Leu Gly Tyr Glu Gly Lys His Cys
        1475                1480                1485            
Glu Arg Cys Ser Ser Ser Tyr Tyr Gly Asn Pro Gln Thr Pro Gly Gly
    1490                1495                1500                
Ser Cys Gln Lys Cys Asp Cys Asn Arg His Gly Ser Val His Gly Asp
1505                1510                1515                1520
Cys Asp Arg Thr Ser Gly Gln Cys Val Cys Arg Leu Gly Ala Ser Gly
                1525                1530                1535    
Leu Arg Cys Asp Glu Cys Glu Pro Arg His Ile Leu Met Glu Thr Asp
            1540                1545                1550        
Cys Val Ser Cys Asp Asp Glu Cys Val Gly Val Leu Leu Asn Asp Leu
        1555                1560                1565            
Asp Glu Ile Gly Asp Ala Val Leu Ser Leu Asn Leu Thr Gly Ile Ile
    1570                1575                1580                
Pro Val Pro Tyr Gly Ile Leu Ser Asn Leu Glu Asn Thr Thr Lys Tyr
1585                1590                1595                1600
Leu Gln Glu Ser Leu Leu Lys Glu Asn Met Gln Lys Asp Leu Gly Lys
                1605                1610                1615    
Ile Lys Leu Glu Gly Val Ala Glu Glu Thr Asp Asn Leu Gln Lys Lys
            1620                1625                1630        
Leu Thr Arg Met Leu Ala Ser Thr Gln Lys Val Asn Arg Ala Thr Glu
        1635                1640                1645            
Arg Ile Phe Lys Glu Ser Gln Asp Leu Ala Val Ala Ile Glu Arg Leu
    1650                1655                1660                
Gln Met Ser Ile Thr Glu Ile Met Glu Lys Thr Thr Leu Asn Gln Thr
1665                1670                1675                1680
Leu Asp Glu Asp Phe Leu Leu Pro Asn Ser Thr Leu Gln Asn Met Gln
                1685                1690                1695    
Gln Asn Gly Thr Ser Leu Leu Glu Ile Met Gln Ile Arg Asp Phe Thr
            1700                1705                1710        
Gln Leu His Gln Asn Ala Thr Leu Glu Leu Lys Ala Ala Glu Asp Leu
        1715                1720                1725            
Leu Ser Gln Ile Gln Glu Asn Tyr Gln Lys Pro Leu Glu Glu Leu Glu
    1730                1735                1740                
Val Leu Lys Glu Ala Ala Ser His Val Leu Ser Lys His Asn Asn Glu
1745                1750                1755                1760
Leu Lys Ala Ala Glu Ala Leu Val Arg Glu Ala Glu Ala Lys Met Gln
                1765                1770                1775    
Glu Ser Asn His Leu Leu Leu Met Val Asn Ala Asn Leu Arg Glu Phe
            1780                1785                1790        
Ser Asp Lys Lys Leu His Val Gln Glu Glu Gln Asn Leu Thr Ser Glu
        1795                1800                1805            
Leu Ile Val Gln Gly Arg Gly Leu Ile Asp Ala Ala Ala Ala Gln Thr
    1810                1815                1820                
Asp Ala Val Gln Asp Ala Leu Glu His Leu Glu Asp His Gln Asp Lys
1825                1830                1835                1840
Leu Leu Leu Trp Ser Ala Lys Ile Arg His His Ile Asp Asp Leu Val
                1845                1850                1855    
Met His Met Ser Gln Arg Asn Ala Val Asp Leu Val Tyr Arg Ala Glu
            1860                1865                1870        
Asp His Ala Thr Glu Phe Gln Arg Leu Ala Asp Val Leu Tyr Ser Gly
        1875                1880                1885            
Leu Glu Asn Ile Arg Asn Val Ser Leu Asn Ala Thr Ser Ala Ala Tyr
    1890                1895                1900                
Val His Tyr Asn Ile Gln Ser Leu Ile Glu Glu Ser Glu Glu Leu Ala
1905                1910                1915                1920
Arg Asp Ala His Arg Thr Val Thr Glu Thr Ser Leu Leu Ser Glu Ser
                1925                1930                1935    
Leu Val Ser Asn Gly Lys Ala Ala Val Gln Arg Ser Ser Arg Phe Leu
            1940                1945                1950        
Lys Glu Gly Asn Asn Leu Ser Arg Lys Leu Pro Gly Ile Ala Leu Glu
        1955                1960                1965            
Leu Ser Glu Leu Arg Asn Lys Thr Asn Arg Phe Gln Glu Asn Ala Val
    1970                1975                1980                
Glu Ile Thr Arg Gln Thr Asn Glu Ser Leu Leu Ile Leu Arg Ala Ile
1985                1990                1995                2000
Pro Glu Gly Ile Arg Asp Lys Gly Ala Lys Thr Lys Glu Leu Ala Thr
                2005                2010                2015    
Ser Ala Ser Gln Ser Ala Val Ser Thr Leu Arg Asp Val Ala Gly Leu
            2020                2025                2030        
Ser Gln Glu Leu Leu Asn Thr Ser Ala Ser Leu Ser Arg Val Asn Thr
        2035                2040                2045            
Thr Leu Arg Glu Thr His Gln Leu Leu Gln Asp Ser Thr Met Ala Thr
    2050                2055                2060                
Leu Leu Ala Gly Arg Lys Val Lys Asp Val Glu Ile Gln Ala Asn Leu
2065                2070                2075                2080
Leu Phe Asp Arg Leu Lys Pro Leu Lys Met Leu Glu Glu Asn Leu Ser
                2085                2090                2095    
Arg Asn Leu Ser Glu Ile Lys Leu Leu Ile Ser Gln Ala Arg Lys Gln
            2100                2105                2110        
Ala Ala Ser Ile Lys Val Ala Val Ser Ala Asp Arg Asp Cys Ile Arg
        2115                2120                2125            
Ala Tyr Gln Pro Gln Ile Ser Ser Thr Asn Tyr Asn Thr Leu Thr Leu
    2130                2135                2140                
Asn Val Lys Thr Gln Glu Pro Asp Asn Leu Leu Phe Tyr Leu Gly Ser
2145                2150                2155                2160
Ser Thr Ala Ser Asp Phe Leu Ala Val Glu Met Arg Arg Gly Arg Val
                2165                2170                2175    
Ala Phe Leu Trp Asp Leu Gly Ser Gly Ser Thr Arg Leu Glu Phe Pro
            2180                2185                2190        
Asp Phe Pro Ile Asp Asp Asn Arg Trp His Ser Ile His Val Ala Arg
        2195                2200                2205            
Phe Gly Asn Ile Gly Ser Leu Ser Val Lys Glu Met Ser Ser Asn Gln
    2210                2215                2220                
Lys Ser Pro Thr Lys Thr Ser Lys Ser Pro Gly Thr Ala Asn Val Leu
2225                2230                2235                2240
Asp Val Asn Asn Ser Thr Leu Met Phe Val Gly Gly Leu Gly Gly Gln
                2245                2250                2255    
Ile Lys Lys Ser Pro Ala Val Lys Val Thr His Phe Lys Gly Cys Leu
            2260                2265                2270        
Gly Glu Ala Phe Leu Asn Gly Lys Ser Ile Gly Leu Trp Asn Tyr Ile
        2275                2280                2285            
Glu Arg Glu Gly Lys Cys Arg Gly Cys Phe Gly Ser Ser Gln Asn Glu
    2290                2295                2300                
Asp Pro Ser Phe His Phe Asp Gly Ser Gly Tyr Ser Val Val Glu Lys
2305                2310                2315                2320
Ser Leu Pro Ala Thr Val Thr Gln Ile Ile Met Leu Phe Asn Thr Phe
                2325                2330                2335    
Ser Pro Asn Gly Leu Leu Leu Tyr Leu Gly Ser Tyr Gly Thr Lys Asp
            2340                2345                2350        
Phe Leu Ser Ile Glu Leu Phe Arg Gly Arg Val Lys Val Met Thr Asp
        2355                2360                2365            
Leu Gly Ser Gly Pro Ile Thr Leu Leu Thr Asp Arg Arg Tyr Asn Asn
    2370                2375                2380                
Gly Thr Trp Tyr Lys Ile Ala Phe Gln Arg Asn Arg Lys Gln Gly Val
2385                2390                2395                2400
Leu Ala Val Ile Asp Ala Tyr Asn Thr Ser Asn Lys Glu Thr Lys Gln
                2405                2410                2415    
Gly Glu Thr Pro Gly Ala Ser Ser Asp Leu Asn Arg Leu Asp Lys Asp
            2420                2425                2430        
Pro Ile Tyr Val Gly Gly Leu Pro Arg Ser Arg Val Val Arg Arg Gly
        2435                2440                2445            
Val Thr Thr Lys Ser Phe Val Gly Cys Ile Lys Asn Leu Glu Ile Ser
    2450                2455                2460                
Arg Ser Thr Phe Asp Leu Leu Arg Asn Ser Tyr Gly Val Arg Lys Gly
2465                2470                2475                2480
Cys Leu Leu Glu Pro Ile Arg Ser Val Ser Phe Leu Lys Gly Gly Tyr
                2485                2490                2495    
Ile Glu Leu Pro Pro Lys Ser Leu Ser Pro Glu Ser Glu Trp Leu Val
            2500                2505                2510        
Thr Phe Ala Thr Thr Asn Ser Ser Gly Ile Ile Leu Ala Ala Leu Gly
        2515                2520                2525            
Gly Asp Val Glu Lys Arg Gly Asp Arg Glu Glu Ala His Val Pro Phe
    2530                2535                2540                
Phe Ser Val Met Leu Ile Gly Gly Asn Ile Glu Val His Val Asn Pro
2545                2550                2555                2560
Gly Asp Gly Thr Gly Leu Arg Lys Ala Leu Leu His Ala Pro Thr Gly
                2565                2570                2575    
Thr Cys Ser Asp Gly Gln Ala His Ser Ile Ser Leu Val Arg Asn Arg
            2580                2585                2590        
Arg Ile Ile Thr Val Gln Leu Asp Glu Asn Asn Pro Val Glu Met Lys
        2595                2600                2605            
Leu Gly Thr Leu Val Glu Ser Arg Thr Ile Asn Val Ser Asn Leu Tyr
    2610                2615                2620                
Val Gly Gly Ile Pro Glu Gly Glu Gly Thr Ser Leu Leu Thr Met Arg
2625                2630                2635                2640
Arg Ser Phe His Gly Cys Ile Lys Asn Leu Ile Phe Asn Leu Glu Leu
                2645                2650                2655    
Leu Asp Phe Asn Ser Ala Val Gly His Glu Gln Val Asp Leu Asp Thr
            2660                2665                2670        
Cys Trp Leu Ser Glu Arg Pro Lys Leu Ala Pro Asp Ala Glu Asp Ser
        2675                2680                2685            
Lys Leu Leu Arg Glu Pro Arg Ala Phe Pro Glu Gln Cys Val Val Asp
    2690                2695                2700                
Ala Ala Leu Glu Tyr Val Pro Gly Ala His Gln Phe Gly Leu Thr Gln
2705                2710                2715                2720
Asn Ser His Phe Ile Leu Pro Phe Asn Gln Ser Ala Val Arg Lys Lys
                2725                2730                2735    
Leu Ser Val Glu Leu Ser Ile Arg Thr Phe Ala Ser Ser Gly Leu Ile
            2740                2745                2750        
Tyr Tyr Met Ala His Gln Asn Gln Ala Asp Tyr Ala Val Leu Gln Leu
        2755                2760                2765            
His Gly Gly Arg Leu His Phe Met Phe Asp Leu Gly Lys Gly Arg Thr
    2770                2775                2780                
Lys Val Ser His Pro Ala Leu Leu Ser Asp Gly Lys Trp His Thr Val
2785                2790                2795                2800
Lys Thr Asp Tyr Val Lys Arg Lys Gly Phe Ile Thr Val Asp Gly Arg
                2805                2810                2815    
Glu Ser Pro Met Val Thr Val Val Gly Asp Gly Thr Met Leu Asp Val
            2820                2825                2830        
Glu Gly Leu Phe Tyr Leu Gly Gly Leu Pro Ser Gln Tyr Gln Ala Arg
        2835                2840                2845            
Lys Ile Gly Asn Ile Thr His Ser Ile Pro Ala Cys Ile Gly Asp Val
    2850                2855                2860                
Thr Val Asn Ser Lys Gln Leu Asp Lys Asp Ser Pro Val Ser Ala Phe
2865                2870                2875                2880
Thr Val Asn Arg Cys Tyr Ala Val Ala Gln Glu Gly Thr Tyr Phe Asp
                2885                2890                2895    
Gly Ser Gly Tyr Ala Ala Leu Val Lys Glu Gly Tyr Lys Val Gln Ser
            2900                2905                2910        
Asp Val Asn Ile Thr Leu Glu Phe Arg Thr Ser Ser Gln Asn Gly Val
        2915                2920                2925            
Leu Leu Gly Ile Ser Thr Ala Lys Val Asp Ala Ile Gly Leu Glu Leu
    2930                2935                2940                
Val Asp Gly Lys Val Leu Phe His Val Asn Asn Gly Ala Gly Arg Ile
2945                2950                2955                2960
Thr Pro Ala Tyr Glu Pro Lys Thr Ala Thr Val Leu Cys Asp Gly Lys
                2965                2970                2975    
Trp His Thr Leu Gln Ala Asn Lys Ser Lys His Arg Ile Thr Leu Ile
            2980                2985                2990        
Val Asp Gly Asn Ala Val Gly Ala Glu Ser Pro His Thr Gln Ser Thr
        2995                3000                3005            
Ser Val Asp Thr Asn Asn Pro Ile Tyr Val Gly Gly Tyr Pro Ala Gly
    3010                3015                3020                
Val Lys Gln Lys Cys Leu Arg Ser Gln Thr Ser Phe Arg Gly Cys Leu
3025                3030                3035                3040
Arg Lys Leu Ala Leu Ile Lys Ser Pro Gln Val Gln Ser Phe Asp Phe
                3045                3050                3055    
Ser Arg Ala Phe Glu Leu His Gly Val Phe Leu His Ser Cys Pro Gly
            3060                3065                3070        
Thr Glu Ser
        3075


<210> 6787
<211> 1192
<212> PRT
<213> Homo sapiens

<400> 6787
Met Glu Val Asp Thr Glu Glu Lys Arg His Arg Thr Arg Ser Lys Gly
 1               5                  10                  15      
Val Arg Val Pro Val Glu Pro Ala Ile Gln Glu Leu Phe Ser Cys Pro
            20                  25                  30          
Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Lys Tyr Ala Arg
        35                  40                  45              
His Arg Ser Val Tyr Gly Cys Pro Leu Ala Lys Lys Arg Lys Thr Gln
    50                  55                  60                  
Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys Arg Lys Pro Phe Ala Val
65                  70                  75                  80  
Lys Ala Asp Ser Ser Ser Val Asp Glu Cys Asp Asp Ser Asp Gly Thr
                85                  90                  95      
Glu Asp Met Asp Glu Lys Glu Glu Asp Glu Gly Glu Glu Tyr Ser Glu
            100                 105                 110         
Asp Asn Asp Glu Pro Gly Asp Glu Asp Glu Glu Asp Glu Glu Gly Asp
        115                 120                 125             
Arg Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Glu Asp Asp Asp Glu
    130                 135                 140                 
Asp Gly Glu Asp Val Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu
145                 150                 155                 160 
Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn Cys His
                165                 170                 175     
Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn Ser Asp
            180                 185                 190         
Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu Asn Leu
        195                 200                 205             
Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu Ser Glu
    210                 215                 220                 
Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp Lys Asn
225                 230                 235                 240 
Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp Ser Asp
                245                 250                 255     
Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln Gly His
            260                 265                 270         
Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala Asp Ser
        275                 280                 285             
Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu Gly Lys
    290                 295                 300                 
Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser Asp Glu
305                 310                 315                 320 
Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys Phe Asp
                325                 330                 335     
Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn Pro Gln
            340                 345                 350         
Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp Phe Pro
        355                 360                 365             
Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu Met Arg
    370                 375                 380                 
Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser Cys Ala
385                 390                 395                 400 
Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser Val Asn
                405                 410                 415     
Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn Leu Thr
            420                 425                 430         
Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys Ala Met
        435                 440                 445             
Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met Arg Ser
    450                 455                 460                 
Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg Lys Pro
465                 470                 475                 480 
Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Gly Lys Asp Pro
                485                 490                 495     
Ser Arg Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp
            500                 505                 510         
Gly Thr Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser
        515                 520                 525             
Gly Cys Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His
    530                 535                 540                 
Glu Ser Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His
545                 550                 555                 560 
Val Asn Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile
                565                 570                 575     
Ala Ala Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys
            580                 585                 590         
Asp Val Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met
        595                 600                 605             
Cys Phe Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn
    610                 615                 620                 
Val Pro Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys
625                 630                 635                 640 
Tyr Ser Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr
                645                 650                 655     
Gly Lys Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro
            660                 665                 670         
Lys Gly Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser
        675                 680                 685             
Ser Ser Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser
    690                 695                 700                 
Cys Gly Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe
705                 710                 715                 720 
Asp Tyr Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile
                725                 730                 735     
Leu Asn Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr
            740                 745                 750         
Lys Pro Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp
        755                 760                 765             
Glu Asn Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp
    770                 775                 780                 
Ser Cys Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln
785                 790                 795                 800 
Gln Ala Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys
                805                 810                 815     
Trp Asp Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp
            820                 825                 830         
Glu Asp Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln
        835                 840                 845             
Glu Ala Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser
    850                 855                 860                 
Pro Lys Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile
865                 870                 875                 880 
Thr Leu Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu
                885                 890                 895     
Ala Thr Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly
            900                 905                 910         
Ser Gly His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly
        915                 920                 925             
Cys Pro Arg Ala Lys Lys Arg Gly Ile Arg Ile Ala Gln Ser Lys Glu
    930                 935                 940                 
Asp Lys Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp
945                 950                 955                 960 
Gly Gln Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser
                965                 970                 975     
Gly Cys Pro Leu Ala Ala Lys Arg Gln Lys Glu Gly Tyr Leu Asn Gly
            980                 985                 990         
Ser Gln Phe Ser Trp Lys Ser Val Lys Thr Glu Gly Met Ser Cys Pro
        995                 1000                1005            
Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Ser Phe Leu Thr
    1010                1015                1020                
His Arg Ser Leu Ser Gly Cys Pro Arg Ala Thr Ser Ala Met Lys Lys
1025                1030                1035                1040
Ala Lys Leu Ser Gly Glu Gln Met Leu Thr Ile Lys Gln Arg Ala Ser
                1045                1050                1055    
Asn Gly Ile Glu Asn Asp Glu Glu Ile Lys Gln Leu Asp Glu Glu Ile
            1060                1065                1070        
Lys Glu Leu Asn Glu Ser Asn Ser Gln Met Glu Ala Asp Met Ile Lys
        1075                1080                1085            
Leu Arg Thr Gln Ile Thr Thr Met Glu Ser Asn Leu Lys Thr Ile Glu
    1090                1095                1100                
Glu Glu Asn Lys Val Val Glu Gln Gln Asn Glu Ser Leu Leu His Glu
1105                1110                1115                1120
Leu Ala Asn Leu Ser Gln Ser Leu Ile His Ser Leu Ala Asn Ile Gln
                1125                1130                1135    
Leu Pro His Met Asp Pro Ile Asn Glu Gln Asn Phe Asp Ala Tyr Val
            1140                1145                1150        
Thr Thr Leu Thr Glu Met Tyr Thr Asn Gln Asp Arg Tyr Gln Ser Pro
        1155                1160                1165            
Glu Asn Lys Ala Leu Leu Glu Asn Ile Lys Gln Ala Val Arg Gly Ile
    1170                1175                1180                
Gln Phe Arg Ser Glu Gln Leu Leu
1185                1190        


<210> 6788
<211> 223
<212> PRT
<213> Homo sapiens

<400> 6788
Asp Tyr Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile
 1               5                  10                  15      
Leu Asn Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr
            20                  25                  30          
Lys Pro Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp
        35                  40                  45              
Glu Asn Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp
    50                  55                  60                  
Ser Cys Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln
65                  70                  75                  80  
Gln Ala Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys
                85                  90                  95      
Trp Asp Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp
            100                 105                 110         
Glu Asp Glu Ser Lys Asp Ile Thr Val Phe Cys Val Pro Cys Asp His
        115                 120                 125             
Pro Cys Gly Ser Glu Ala Val Phe Cys Pro Gln Pro Glu Asp Leu Asp
    130                 135                 140                 
Pro Phe Gln Glu Ala Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr
145                 150                 155                 160 
Ile Pro Ser Pro Lys Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys
                165                 170                 175     
Asp Leu Ile Thr Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His Val
            180                 185                 190         
Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro Leu Ala
        195                 200                 205             
Asp Lys Ser Ile Arg Ser Met Leu Ala Thr Ser Ser Gln Glu Leu
    210                 215                 220             


<210> 6789
<211> 1154
<212> PRT
<213> Homo sapiens

<400> 6789
Leu Trp Ala Cys Val Leu Pro Gly Val Thr Leu Pro Pro Phe Leu Gly
 1               5                  10                  15      
Glu Lys Thr Ser Cys Lys Met Glu Val Asp Thr Glu Glu Lys Arg His
            20                  25                  30          
Arg Thr Arg Ser Lys Gly Val Arg Val Pro Val Glu Pro Ala Ile Gln
        35                  40                  45              
Glu Leu Phe Ser Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His Val
    50                  55                  60                  
Ser Gly Lys Tyr Ala Arg His Arg Ser Val Tyr Gly Cys Pro Leu Ala
65                  70                  75                  80  
Lys Lys Arg Lys Thr Gln Asp Lys Gln Pro Gln Glu Pro Ala Pro Lys
                85                  90                  95      
Arg Lys Pro Phe Ala Val Lys Ala Asp Ser Ser Ser Val Asp Glu Cys
            100                 105                 110         
Asp Asp Ser Asp Gly Thr Glu Asp Met Asp Glu Lys Glu Glu Asp Glu
        115                 120                 125             
Gly Glu Glu Glu Glu Glu Glu Glu Glu Asn Glu Asp His Gln Met Asn
    130                 135                 140                 
Cys His Asn Thr Arg Ile Met Gln Asp Thr Glu Lys Asp Asp Asn Asn
145                 150                 155                 160 
Asn Asp Glu Tyr Asp Asn Tyr Asp Glu Leu Val Ala Lys Ser Leu Leu
                165                 170                 175     
Asn Leu Gly Lys Ile Ala Glu Asp Ala Ala Tyr Arg Ala Arg Thr Glu
            180                 185                 190         
Ser Glu Met Asn Ser Asn Thr Ser Asn Ser Leu Glu Asp Asp Ser Asp
        195                 200                 205             
Lys Asn Glu Asn Leu Gly Arg Lys Ser Glu Leu Ser Leu Asp Leu Asp
    210                 215                 220                 
Ser Asp Val Val Arg Glu Thr Val Asp Ser Leu Lys Leu Leu Ala Gln
225                 230                 235                 240 
Gly His Gly Val Val Leu Ser Glu Asn Met Asn Asp Arg Asn Tyr Ala
                245                 250                 255     
Asp Ser Met Ser Gln Gln Asp Ser Arg Asn Met Asn Tyr Val Met Leu
            260                 265                 270         
Gly Lys Pro Met Asn Asn Gly Leu Met Glu Lys Met Val Glu Glu Ser
        275                 280                 285             
Asp Glu Glu Val Cys Leu Ser Ser Leu Glu Cys Leu Arg Asn Gln Cys
    290                 295                 300                 
Phe Asp Leu Ala Arg Lys Leu Ser Glu Thr Asn Pro Gln Glu Arg Asn
305                 310                 315                 320 
Pro Gln Gln Asn Met Asn Ile Arg Gln His Val Arg Pro Glu Glu Asp
                325                 330                 335     
Phe Pro Gly Arg Thr Pro Asp Arg Asn Tyr Ser Asp Met Leu Asn Leu
            340                 345                 350         
Met Arg Leu Glu Glu Gln Leu Ser Pro Arg Ser Arg Val Phe Ala Ser
        355                 360                 365             
Cys Ala Lys Glu Asp Gly Cys His Glu Arg Asp Asp Asp Thr Thr Ser
    370                 375                 380                 
Val Asn Ser Asp Arg Ser Glu Glu Val Phe Asp Met Thr Lys Gly Asn
385                 390                 395                 400 
Leu Thr Leu Leu Glu Lys Ala Ile Ala Leu Glu Thr Glu Arg Ala Lys
                405                 410                 415     
Ala Met Arg Glu Lys Met Ala Met Glu Ala Gly Arg Arg Asp Asn Met
            420                 425                 430         
Arg Ser Tyr Glu Asp Gln Ser Pro Arg Gln Leu Pro Gly Glu Asp Arg
        435                 440                 445             
Lys Pro Lys Ser Ser Asp Ser His Val Lys Lys Pro Tyr Tyr Asp Pro
    450                 455                 460                 
Ser Arg Thr Glu Lys Lys Glu Ser Lys Cys Pro Thr Pro Gly Cys Asp
465                 470                 475                 480 
Gly Thr Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser
                485                 490                 495     
Gly Cys Pro His Lys Asp Arg Val Pro Pro Glu Ile Leu Ala Met His
            500                 505                 510         
Glu Ser Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Arg Gly His
        515                 520                 525             
Val Asn Ser Asn Arg Asn Ser His Arg Ser Leu Ser Gly Cys Pro Ile
    530                 535                 540                 
Ala Ala Ala Glu Lys Leu Ala Lys Ala Gln Glu Lys His Gln Ser Cys
545                 550                 555                 560 
Asp Val Ser Lys Ser Ser Gln Ala Ser Asp Arg Val Leu Arg Pro Met
                565                 570                 575     
Cys Phe Val Lys Gln Leu Glu Ile Pro Gln Tyr Gly Tyr Arg Asn Asn
            580                 585                 590         
Val Pro Thr Thr Thr Pro Arg Ser Asn Leu Ala Lys Glu Leu Glu Lys
        595                 600                 605             
Tyr Ser Lys Thr Ser Phe Glu Tyr Asn Ser Tyr Asp Asn His Thr Tyr
    610                 615                 620                 
Gly Lys Arg Ala Ile Ala Pro Lys Val Gln Thr Arg Asp Ile Ser Pro
625                 630                 635                 640 
Lys Gly Tyr Asp Asp Ala Lys Arg Tyr Cys Lys Asp Pro Ser Pro Ser
                645                 650                 655     
Ser Ser Ser Thr Ser Ser Tyr Ala Pro Ser Ser Ser Ser Asn Leu Ser
            660                 665                 670         
Cys Gly Gly Gly Ser Ser Ala Ser Ser Thr Cys Ser Lys Ser Ser Phe
        675                 680                 685             
Asp Tyr Thr His Asp Met Glu Ala Ala His Met Ala Ala Thr Ala Ile
    690                 695                 700                 
Leu Asn Leu Ser Thr Arg Cys Arg Glu Met Pro Gln Asn Leu Ser Thr
705                 710                 715                 720 
Lys Pro Gln Asp Leu Cys Ala Thr Arg Asn Pro Asp Met Glu Val Asp
                725                 730                 735     
Glu Asn Gly Thr Leu Asp Leu Ser Met Asn Lys Gln Arg Pro Arg Asp
            740                 745                 750         
Ser Cys Cys Pro Ile Leu Thr Pro Leu Glu Pro Met Ser Pro Gln Gln
        755                 760                 765             
Gln Ala Val Met Asn Asn Arg Cys Phe Gln Leu Gly Glu Gly Asp Cys
    770                 775                 780                 
Trp Asp Leu Pro Val Asp Tyr Thr Lys Met Lys Pro Arg Arg Ile Asp
785                 790                 795                 800 
Glu Asp Glu Ser Lys Asp Ile Thr Pro Glu Asp Leu Asp Pro Phe Gln
                805                 810                 815     
Glu Ala Leu Glu Glu Arg Arg Tyr Pro Gly Glu Val Thr Ile Pro Ser
            820                 825                 830         
Pro Lys Pro Lys Tyr Pro Gln Cys Lys Glu Ser Lys Lys Asp Leu Ile
        835                 840                 845             
Thr Leu Ser Gly Cys Pro Leu Ala Asp Lys Ser Ile Arg Ser Met Leu
    850                 855                 860                 
Ala Thr Ser Ser Gln Glu Leu Lys Cys Pro Thr Pro Gly Cys Asp Gly
865                 870                 875                 880 
Ser Gly His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly
                885                 890                 895     
Cys Pro Arg Ala Lys Lys Ser Gly Ile Arg Ile Ala Gln Ser Lys Glu
            900                 905                 910         
Asp Lys Glu Asp Gln Glu Pro Ile Arg Cys Pro Val Pro Gly Cys Asp
        915                 920                 925             
Gly Gln Gly His Ile Thr Gly Lys Tyr Ala Ser His Arg Ser Ala Ser
    930                 935                 940                 
Gly Cys Pro Leu Ala Ala Lys Arg Gln Lys Asp Gly Tyr Leu Asn Gly
945                 950                 955                 960 
Ser Gln Phe Ser Trp Lys Ser Val Lys Thr Glu Gly Met Ser Cys Pro
                965                 970                 975     
Thr Pro Gly Cys Asp Gly Ser Gly His Val Ser Gly Ser Phe Leu Thr
            980                 985                 990         
His Arg Ser Leu Ser Gly Cys Pro Arg Ala Thr Ser Ala Met Lys Lys
        995                 1000                1005            
Ala Lys Leu Ser Gly Glu Gln Met Leu Thr Ile Lys Gln Arg Ala Ser
    1010                1015                1020                
Asn Gly Ile Glu Asn Asp Glu Glu Ile Lys Gln Leu Asp Glu Glu Ile
1025                1030                1035                1040
Lys Glu Leu Asn Glu Ser Asn Ser Gln Met Glu Ala Asp Met Ile Lys
                1045                1050                1055    
Leu Arg Thr Gln Ile Thr Thr Met Glu Ser Asn Leu Lys Thr Ile Glu
            1060                1065                1070        
Glu Glu Asn Lys Val Ile Glu Gln Gln Asn Glu Ser Leu Leu His Glu
        1075                1080                1085            
Leu Ala Asn Leu Ser Gln Ser Leu Ile His Ser Leu Ala Asn Ile Gln
    1090                1095                1100                
Leu Pro His Met Asp Pro Ile Asn Glu Gln Asn Phe Asp Ala Tyr Val
1105                1110                1115                1120
Thr Thr Leu Thr Glu Met Tyr Thr Asn Gln Asp Arg Tyr Gln Ser Pro
                1125                1130                1135    
Glu Asn Lys Ala Leu Leu Glu Asn Ile Lys Gln Ala Val Arg Gly Ile
            1140                1145                1150        
Gln Val
        


<210> 6790
<211> 1107
<212> PRT
<213> Homo sapiens

<400> 6790
Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu
 1               5                  10                  15      
Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly
            20                  25                  30          
Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser
        35                  40                  45              
Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg
    50                  55                  60                  
Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr
65                  70                  75                  80  
Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly
                85                  90                  95      
Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu
            100                 105                 110         
Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu
        115                 120                 125             
Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu
    130                 135                 140                 
Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu
145                 150                 155                 160 
His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln
                165                 170                 175     
Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr
            180                 185                 190         
Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg
        195                 200                 205             
Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val
    210                 215                 220                 
Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn
225                 230                 235                 240 
Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Val Ile Gly
                245                 250                 255     
Arg Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His
            260                 265                 270         
Ile Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly
        275                 280                 285             
Thr Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu
    290                 295                 300                 
Lys Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu
305                 310                 315                 320 
Gly Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr
                325                 330                 335     
Leu Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe
            340                 345                 350         
Lys Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu
        355                 360                 365             
Ser Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu
    370                 375                 380                 
Val Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe
385                 390                 395                 400 
His Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val
                405                 410                 415     
Pro Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu
            420                 425                 430         
Gln Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile
        435                 440                 445             
Trp Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro
    450                 455                 460                 
Thr Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn
465                 470                 475                 480 
Val Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu
                485                 490                 495     
Arg Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg
            500                 505                 510         
Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser
        515                 520                 525             
Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val
    530                 535                 540                 
Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys
545                 550                 555                 560 
Pro Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp
                565                 570                 575     
Gly His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser
            580                 585                 590         
Thr Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly
        595                 600                 605             
Ser Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser
    610                 615                 620                 
His Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr
625                 630                 635                 640 
Ala Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met
                645                 650                 655     
Ser His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys
            660                 665                 670         
Thr Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly
        675                 680                 685             
Asp Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His
    690                 695                 700                 
His Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala
705                 710                 715                 720 
Leu Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu
                725                 730                 735     
Ser Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr
            740                 745                 750         
Val Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu
        755                 760                 765             
Ser Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro
    770                 775                 780                 
Glu Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser
785                 790                 795                 800 
Tyr Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu
                805                 810                 815     
Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn
            820                 825                 830         
Val Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu
        835                 840                 845             
Ala Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr
    850                 855                 860                 
Phe Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu
865                 870                 875                 880 
Tyr Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu
                885                 890                 895     
Ile Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu
            900                 905                 910         
Gln Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala
        915                 920                 925             
His Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu
    930                 935                 940                 
Lys Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu
945                 950                 955                 960 
Arg Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu
                965                 970                 975     
Glu Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg
            980                 985                 990         
Leu Pro Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val
        995                 1000                1005            
Leu Tyr Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile
    1010                1015                1020                
Pro Leu Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu
1025                1030                1035                1040
Gly Ser Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser
                1045                1050                1055    
Ser Thr Ile Ser Cys Asp Ser Pro Leu Glu Pro Gln Asp Glu Pro Glu
            1060                1065                1070        
Pro Glu Pro Gln Leu Glu Leu Gln Val Glu Pro Glu Pro Glu Leu Glu
        1075                1080                1085            
Gln Leu Pro Asp Ser Gly Cys Pro Ala Pro Arg Ala Glu Ala Glu Asp
    1090                1095                1100                
Ser Phe Leu
1105        


<210> 6791
<211> 558
<212> PRT
<213> Homo sapiens

<400> 6791
Met Glu Leu Arg Ala Arg Gly Trp Trp Leu Leu Cys Ala Ala Ala Ala
 1               5                  10                  15      
Leu Val Ala Cys Ala Arg Gly Asp Pro Ala Ser Lys Ser Arg Ser Cys
            20                  25                  30          
Gly Glu Val Arg Gln Ile Tyr Gly Ala Lys Gly Phe Ser Leu Ser Asp
        35                  40                  45              
Val Pro Gln Ala Glu Ile Ser Gly Glu His Leu Arg Ile Cys Pro Gln
    50                  55                  60                  
Gly Tyr Thr Cys Cys Thr Ser Glu Met Glu Glu Asn Leu Ala Asn Arg
65                  70                  75                  80  
Ser His Ala Glu Leu Glu Thr Ala Leu Arg Asp Ser Ser Arg Val Leu
                85                  90                  95      
Gln Ala Met Leu Ala Thr Gln Leu Arg Ser Phe Asp Asp His Phe Gln
            100                 105                 110         
His Leu Leu Asn Asp Ser Glu Arg Thr Leu Gln Ala Thr Phe Pro Gly
        115                 120                 125             
Ala Phe Gly Glu Leu Tyr Thr Gln Asn Ala Arg Ala Phe Arg Asp Leu
    130                 135                 140                 
Tyr Ser Glu Leu Arg Leu Tyr Tyr Arg Gly Ala Asn Leu His Leu Glu
145                 150                 155                 160 
Glu Thr Leu Ala Glu Phe Trp Ala Arg Leu Leu Glu Arg Leu Phe Lys
                165                 170                 175     
Gln Leu His Pro Gln Leu Leu Leu Pro Asp Asp Tyr Leu Asp Cys Leu
            180                 185                 190         
Gly Lys Gln Ala Glu Ala Leu Arg Pro Phe Gly Glu Ala Pro Arg Glu
        195                 200                 205             
Leu Arg Leu Arg Ala Thr Arg Ala Phe Val Ala Ala Arg Ser Phe Val
    210                 215                 220                 
Gln Gly Leu Gly Val Ala Ser Asp Val Val Arg Lys Val Ala Gln Val
225                 230                 235                 240 
Pro Leu Gly Pro Glu Cys Ser Arg Ala Val Met Lys Leu Val Tyr Cys
                245                 250                 255     
Ala His Cys Leu Gly Val Pro Gly Ala Arg Pro Cys Pro Asp Tyr Cys
            260                 265                 270         
Arg Asn Val Leu Lys Gly Cys Leu Ala Asn Gln Ala Asp Leu Asp Ala
        275                 280                 285             
Glu Trp Arg Asn Leu Leu Asp Ser Met Val Leu Ile Thr Asp Lys Phe
    290                 295                 300                 
Trp Gly Thr Ser Gly Val Glu Ser Val Ile Gly Ser Val His Thr Trp
305                 310                 315                 320 
Leu Ala Glu Ala Ile Asn Ala Leu Gln Asp Asn Arg Asp Thr Leu Thr
                325                 330                 335     
Ala Lys Val Ile Gln Gly Cys Gly Asn Pro Lys Val Asn Pro Gln Gly
            340                 345                 350         
Pro Gly Pro Glu Glu Lys Arg Arg Arg Gly Lys Leu Ala Pro Arg Glu
        355                 360                 365             
Arg Pro Pro Ser Gly Thr Leu Glu Lys Leu Val Ser Glu Ala Lys Ala
    370                 375                 380                 
Gln Leu Arg Asp Val Gln Asp Phe Trp Ile Ser Leu Pro Gly Thr Leu
385                 390                 395                 400 
Cys Ser Glu Lys Met Ala Leu Ser Thr Ala Ser Asp Asp Arg Cys Trp
                405                 410                 415     
Asn Gly Met Ala Arg Gly Arg Tyr Leu Pro Glu Val Met Gly Asp Gly
            420                 425                 430         
Leu Ala Asn Gln Ile Asn Asn Pro Glu Val Glu Val Asp Ile Thr Lys
        435                 440                 445             
Pro Asp Met Thr Ile Arg Gln Gln Ile Met Gln Leu Lys Ile Met Thr
    450                 455                 460                 
Asn Arg Leu Arg Ser Ala Tyr Asn Gly Asn Asp Val Asp Phe Gln Asp
465                 470                 475                 480 
Ala Ser Asp Asp Gly Ser Gly Ser Gly Ser Gly Asp Gly Cys Leu Asp
                485                 490                 495     
Asp Leu Cys Gly Arg Lys Val Ser Arg Lys Ser Ser Ser Ser Arg Thr
            500                 505                 510         
Pro Leu Thr His Ala Leu Pro Gly Leu Ser Glu Gln Glu Gly Gln Lys
        515                 520                 525             
Thr Ser Ala Ala Ser Cys Pro Gln Pro Pro Thr Phe Leu Leu Pro Leu
    530                 535                 540                 
Leu Leu Phe Leu Ala Leu Thr Val Ala Arg Pro Arg Trp Arg
545                 550                 555             


<210> 6792
<211> 287
<212> PRT
<213> Homo sapiens

<400> 6792
Met Pro Pro Leu Trp Ala Leu Leu Ala Leu Gly Cys Leu Arg Phe Gly
 1               5                  10                  15      
Ser Ala Val Asn Leu Gln Pro Gln Leu Ala Ser Val Thr Phe Ala Thr
            20                  25                  30          
Asn Asn Pro Thr Leu Thr Thr Val Ala Leu Glu Lys Pro Leu Cys Met
        35                  40                  45              
Phe Asp Ser Lys Glu Ala Leu Thr Gly Thr His Glu Val Tyr Leu Tyr
    50                  55                  60                  
Val Leu Val Asp Ser Ala Ile Ser Arg Asn Ala Ser Val Gln Asp Ser
65                  70                  75                  80  
Thr Asn Thr Pro Leu Gly Ser Thr Phe Leu Gln Thr Glu Gly Gly Arg
                85                  90                  95      
Thr Gly Pro Tyr Lys Ala Val Ala Phe Asp Leu Ile Pro Cys Ser Asp
            100                 105                 110         
Leu Pro Ser Leu Asp Ala Ile Gly Asp Val Ser Lys Ala Ser Gln Ile
        115                 120                 125             
Leu Asn Ala Tyr Leu Val Arg Val Gly Ala Asn Gly Thr Cys Leu Trp
    130                 135                 140                 
Asp Pro Asn Phe Gln Gly Leu Cys Asn Pro Pro Leu Ser Ala Ala Thr
145                 150                 155                 160 
Glu Tyr Arg Phe Lys Tyr Val Leu Val Asn Met Ser Thr Gly Leu Val
                165                 170                 175     
Glu Asp Gln Thr Leu Trp Ser Asp Pro Ile Arg Thr Asn Gln Leu Thr
            180                 185                 190         
Pro Tyr Ser Thr Ile Asp Thr Trp Pro Gly Arg Arg Ser Gly Gly Met
        195                 200                 205             
Ile Val Ile Thr Ser Ile Leu Gly Ser Leu Pro Phe Phe Leu Leu Val
    210                 215                 220                 
Gly Phe Ala Gly Ala Ile Ala Leu Ser Leu Val Ala Met Gly Ser Ser
225                 230                 235                 240 
Asp Gly Glu Thr Thr His Asp Ser Gln Ile Thr Gln Glu Ala Val Pro
                245                 250                 255     
Lys Ser Leu Gly Ala Ser Glu Ser Ser Tyr Thr Ser Val Asn Arg Gly
            260                 265                 270         
Pro Pro Leu Asp Arg Ala Glu Val Tyr Ser Ser Lys Leu Gln Asp
        275                 280                 285         


<210> 6793
<211> 366
<212> PRT
<213> Homo sapiens

<400> 6793
Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile
            20                  25                  30          
Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His
        35                  40                  45              
Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala
    50                  55                  60                  
Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu
65                  70                  75                  80  
Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val
                85                  90                  95      
Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro
            100                 105                 110         
Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe
        115                 120                 125             
Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly
    130                 135                 140                 
Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro
145                 150                 155                 160 
Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr
                165                 170                 175     
Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn
            180                 185                 190         
His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val
        195                 200                 205             
Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro
    210                 215                 220                 
Gly Leu Leu Ala Thr Arg Val Glu Val Pro Leu Leu Gly Ile Val Val
225                 230                 235                 240 
Ala Ala Gly Leu Ala Leu Gly Thr Leu Val Gly Phe Ser Thr Leu Val
                245                 250                 255     
Ala Cys Leu Val Cys Arg Lys Glu Lys Lys Thr Lys Gly Pro Ser Arg
            260                 265                 270         
His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu Lys Leu Asn Asn
        275                 280                 285             
Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser Asn Leu Gln Leu
    290                 295                 300                 
Asn Asp Leu Thr Pro Asp Ser Arg Ala Val Lys Pro Ala Asp Arg Gln
305                 310                 315                 320 
Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp Pro Glu Pro Gly
                325                 330                 335     
Gly Leu Leu Thr Ser Gln Gly Phe Ile Arg Leu Pro Val Leu Gly Tyr
            340                 345                 350         
Ile Tyr Arg Val Ser Ser Val Ser Ser Asp Glu Ile Trp Leu
        355                 360                 365     


<210> 6794
<211> 218
<212> PRT
<213> Homo sapiens

<400> 6794
Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Leu Leu Ser Ser Val Lys Pro Glu Ile Ala Gln Val Gly
            20                  25                  30          
Ala Lys Tyr Gln Glu Ala Gln Gly Pro Gly Leu Leu Val Val Leu Phe
        35                  40                  45              
Ala Leu Val Arg Ala Asn Pro Pro Ala Asn Val Thr Trp Ile Asp Gln
    50                  55                  60                  
Asp Gly Pro Val Thr Val Asn Thr Ser Asp Phe Leu Val Leu Asp Ala
65                  70                  75                  80  
Gln Asn Tyr Pro Trp Leu Thr Asn His Thr Val Gln Leu Gln Leu Arg
                85                  90                  95      
Ser Leu Ala His Asn Leu Ser Val Val Ala Thr Asn Asp Val Gly Val
            100                 105                 110         
Thr Ser Ala Ser Leu Pro Ala Pro Gly Pro Ser Arg His Pro Ser Leu
        115                 120                 125             
Ile Ser Ser Asp Ser Asn Asn Leu Lys Leu Asn Asn Val Arg Leu Pro
    130                 135                 140                 
Arg Glu Asn Met Ser Leu Pro Ser Asn Leu Gln Leu Asn Asp Leu Thr
145                 150                 155                 160 
Pro Asp Ser Arg Ala Val Lys Pro Ala Asp Arg Gln Met Ala Gln Asn
                165                 170                 175     
Asn Ser Arg Pro Glu Leu Leu Asp Pro Glu Pro Gly Gly Leu Leu Thr
            180                 185                 190         
Ser Gln Gly Phe Ile Arg Leu Pro Val Leu Gly Tyr Ile Tyr Arg Val
        195                 200                 205             
Ser Ser Val Ser Ser Asp Glu Ile Trp Leu
    210                 215             


<210> 6795
<211> 322
<212> PRT
<213> Homo sapiens

<400> 6795
Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu
 1               5                  10                  15      
Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile
            20                  25                  30          
Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His
        35                  40                  45              
Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala
    50                  55                  60                  
Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu
65                  70                  75                  80  
Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val
                85                  90                  95      
Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro
            100                 105                 110         
Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe
        115                 120                 125             
Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly
    130                 135                 140                 
Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro
145                 150                 155                 160 
Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr
                165                 170                 175     
Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn
            180                 185                 190         
His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val
        195                 200                 205             
Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro
    210                 215                 220                 
Gly Pro Ser Arg His Pro Ser Leu Ile Ser Ser Asp Ser Asn Asn Leu
225                 230                 235                 240 
Lys Leu Asn Asn Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser
                245                 250                 255     
Asn Leu Gln Leu Asn Asp Leu Thr Pro Asp Ser Arg Ala Val Lys Pro
            260                 265                 270         
Ala Asp Arg Gln Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp
        275                 280                 285             
Pro Glu Pro Gly Gly Leu Leu Thr Ser Arg Gly Phe Ile Arg Leu Pro
    290                 295                 300                 
Val Leu Gly Tyr Ile Tyr Arg Val Ser Ser Val Ser Ser Asp Glu Ile
305                 310                 315                 320 
Trp Leu
        


<210> 6796
<211> 314
<212> PRT
<213> Homo sapiens

<400> 6796
Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala
 1               5                  10                  15      
Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr
            20                  25                  30          
Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys
        35                  40                  45              
Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala
    50                  55                  60                  
Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg
65                  70                  75                  80  
Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp
                85                  90                  95      
Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly
            100                 105                 110         
Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp
        115                 120                 125             
Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile
    130                 135                 140                 
Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys
145                 150                 155                 160 
Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu
                165                 170                 175     
Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr
            180                 185                 190         
Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp
        195                 200                 205             
Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser
    210                 215                 220                 
Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu
225                 230                 235                 240 
Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala
                245                 250                 255     
Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile
            260                 265                 270         
Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile
        275                 280                 285             
Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu
    290                 295                 300                 
Met Gly Glu Met His Arg Glu Leu Asn Ala
305                 310                 


<210> 6797
<211> 314
<212> PRT
<213> Homo sapiens

<400> 6797
Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala
 1               5                  10                  15      
Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr
            20                  25                  30          
Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys
        35                  40                  45              
Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala
    50                  55                  60                  
Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg
65                  70                  75                  80  
Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp
                85                  90                  95      
Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly
            100                 105                 110         
Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp
        115                 120                 125             
Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile
    130                 135                 140                 
Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys
145                 150                 155                 160 
Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu
                165                 170                 175     
Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr
            180                 185                 190         
Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp
        195                 200                 205             
Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser
    210                 215                 220                 
Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu
225                 230                 235                 240 
Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala
                245                 250                 255     
Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile
            260                 265                 270         
Val Val Val Val Met Ala Val Val Ala Gly Ile Val Val Leu Val Ile
        275                 280                 285             
Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu
    290                 295                 300                 
Met Gly Glu Met His Arg Glu Leu Asn Ala
305                 310                 


<210> 6798
<211> 222
<212> PRT
<213> Homo sapiens

<400> 6798
Met Ser Leu Met Val Ile Ile Met Ala Cys Val Gly Phe Phe Leu Leu
 1               5                  10                  15      
Gln Gly Ala Trp Pro Gln Glu Gly Val His Arg Lys Pro Ser Phe Leu
            20                  25                  30          
Ala Leu Pro Gly His Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln
        35                  40                  45              
Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly
    50                  55                  60                  
Lys Phe Asn Asn Thr Leu His Leu Ile Gly Glu His His Asp Gly Val
65                  70                  75                  80  
Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly
                85                  90                  95      
Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser
            100                 105                 110         
Ala Pro Ser Asp Pro Leu Asp Met Val Ile Ile Gly Leu Tyr Glu Lys
        115                 120                 125             
Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn
    130                 135                 140                 
Val Thr Leu Ser Cys Ser Ser Ile Tyr Pro Gly Arg Gly Arg Pro Met
145                 150                 155                 160 
Asn Val Gly Ser Leu Gln Cys Ala Ala Ser Thr Glu His Ser Arg Pro
                165                 170                 175     
Thr Phe Leu Trp Ala Leu Pro Pro Thr Glu Gly Pro Thr Asp Ala Ser
            180                 185                 190         
Ala Leu Ser Val Thr Leu Pro Thr Ser Gly Gln Thr Arg Val Ile His
        195                 200                 205             
Cys Leu Phe Pro Ser Gln Val Thr Pro Asp Thr Tyr Met Phe
    210                 215                 220         


<210> 6799
<211> 304
<212> PRT
<213> Homo sapiens

<400> 6799
Met Ser Leu Met Val Ile Ile Met Ala Cys Val Gly Phe Phe Leu Leu
 1               5                  10                  15      
Gln Gly Ala Trp Pro Gln Glu Gly Val His Arg Lys Pro Ser Phe Leu
            20                  25                  30          
Ala Leu Pro Gly His Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln
        35                  40                  45              
Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly
    50                  55                  60                  
Lys Phe Asn Asn Thr Leu His Leu Ile Gly Glu His His Asp Gly Val
65                  70                  75                  80  
Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly
                85                  90                  95      
Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser
            100                 105                 110         
Ala Pro Ser Asp Pro Leu Asp Met Val Ile Ile Gly Leu Tyr Glu Lys
        115                 120                 125             
Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn
    130                 135                 140                 
Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu
145                 150                 155                 160 
Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Val Arg Ser
                165                 170                 175     
Ile Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His
            180                 185                 190         
Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ala Pro Tyr Glu
        195                 200                 205             
Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro
    210                 215                 220                 
Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn
225                 230                 235                 240 
Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro
                245                 250                 255     
Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys
            260                 265                 270         
Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val
        275                 280                 285             
Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala
    290                 295                 300                 


<210> 6800
<211> 105
<212> PRT
<213> Homo sapiens

<400> 6800
His Glu Gly Val His Arg Lys Pro Ser Phe Leu Ala Leu Pro Gly His
 1               5                  10                  15      
Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val
            20                  25                  30          
Arg Phe Glu His Phe Leu Leu His Arg Glu Gly Lys Phe Asn Asn Thr
        35                  40                  45              
Leu His Leu Ile Gly Glu His His Asp Gly Val Ser Lys Ala Asn Phe
    50                  55                  60                  
Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly Thr Tyr Arg Cys Phe
65                  70                  75                  80  
Gly Ser Phe Arg Asp Ala Pro Tyr Glu Trp Ser Asn Ser Ser Asp Pro
                85                  90                  95      
Leu Leu Val Ser Val Thr Gly Asn Pro
            100                 105 


<210> 6801
<211> 203
<212> PRT
<213> Homo sapiens

<400> 6801
His Glu Gly Val His Arg Lys Pro Ser Phe Leu Ala Leu Pro Gly His
 1               5                  10                  15      
Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val
            20                  25                  30          
Met Phe Glu His Phe Leu Leu His Arg Glu Gly Lys Phe Asn Asn Thr
        35                  40                  45              
Leu His Leu Ile Gly Glu His His Asp Gly Val Ser Lys Ala Asn Phe
    50                  55                  60                  
Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly Thr Tyr Arg Cys Tyr
65                  70                  75                  80  
Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro
                85                  90                  95      
Leu Asp Met Val Ile Ile Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala
            100                 105                 110         
Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser Val Thr Leu Ser Cys
        115                 120                 125             
Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Glu
    130                 135                 140                 
Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys Val Asn Gly Thr Phe
145                 150                 155                 160 
Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg
                165                 170                 175     
Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu Trp Ser Lys Ser Ser
            180                 185                 190         
Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro
        195                 200             


<210> 6802
<211> 504
<212> PRT
<213> Homo sapiens

<400> 6802
Met Leu Arg Leu Val Ala Ala Cys Pro Glu Ser Cys Val Val Cys Thr
 1               5                  10                  15      
Lys Asp Val Thr Leu Cys His Gln Leu Thr Tyr Ile Val Ala Ala Pro
            20                  25                  30          
Met Thr Thr Arg Val Leu Ile Ile Thr Asp Gly Tyr Leu Ser Ser Ile
        35                  40                  45              
Glu Ser Thr Asn Leu Ser Leu Leu Phe Asn Leu Ala Leu Leu Ser Leu
    50                  55                  60                  
Ser Arg Asn Gly Ile Glu Asp Val Gln Glu Asp Ala Leu His Gly Leu
65                  70                  75                  80  
Thr Met Leu Arg Thr Leu Leu Leu Glu His Asn Gln Ile Ser Ser Ser
                85                  90                  95      
Ser Leu Thr Asp His Thr Phe Ser Lys Leu His Ser Leu Gln Val Leu
            100                 105                 110         
Val Leu Ser Asn Asn Ala Leu Arg Thr Leu Arg Gly Ser Trp Phe Arg
        115                 120                 125             
Asn Thr Ser Gly Leu Thr Arg Leu Gln Leu Asp Gly Asn Gln Ile Thr
    130                 135                 140                 
Asn Leu Thr Asp Ser Ser Phe Gly Gly Thr Asn Leu His Ser Leu Arg
145                 150                 155                 160 
Tyr Leu Asp Leu Ser Asn Asn Phe Ile Ser Tyr Ile Gly Lys Asp Ala
                165                 170                 175     
Phe Arg Pro Leu Pro Gln Leu Gln Glu Val Asp Leu Ser Arg Asn Arg
            180                 185                 190         
Leu Ala His Met Pro Asp Val Phe Thr Pro Leu Lys Gln Leu Ile Leu
        195                 200                 205             
Leu Ser Leu Asp Lys Asn Gln Trp Ser Cys Thr Cys Asp Leu His Pro
    210                 215                 220                 
Leu Ala Arg Phe Leu Arg Asn Tyr Ile Lys Ser Ser Ala His Thr Leu
225                 230                 235                 240 
Arg Asn Ala Lys Asp Leu Asn Cys Gln Pro Ser Thr Ala Ala Val Ala
                245                 250                 255     
Ala Ala Gln Ser Val Leu Arg Leu Ser Glu Thr Asn Cys Asp Ser Lys
            260                 265                 270         
Ala Pro Asn Phe Thr Leu Val Leu Lys Asp Arg Ser Pro Leu Leu Pro
        275                 280                 285             
Gly Pro Asp Val Ala Leu Leu Thr Val Leu Gly Phe Ala Gly Ala Val
    290                 295                 300                 
Gly Leu Thr Cys Leu Gly Leu Val Val Phe Asn Trp Lys Leu His Gln
305                 310                 315                 320 
Gly Lys Ala Asn Glu His Thr Ser Glu Asn Leu Cys Cys Arg Thr Phe
                325                 330                 335     
Asp Glu Pro Leu Cys Ala His Glu Ala Arg Asn Tyr His Thr Lys Gly
            340                 345                 350         
Tyr Cys Asn Cys His Leu Thr Gln Glu Asn Glu Ile Lys Val Met Ser
        355                 360                 365             
Thr Val Gly Ser Arg Lys Glu Met Pro Leu Leu Gln Glu Asn Ser His
    370                 375                 380                 
Gln Ala Thr Ser Ala Ser Glu Ser Ala Thr Leu Asp Gly Ser Phe Arg
385                 390                 395                 400 
Asn Leu Lys Lys Lys Asp Arg Gly Val Gly Ser Thr Leu Phe Cys Gln
                405                 410                 415     
Asp Gly Arg Leu Leu His Ser Glu Cys Ser Glu Pro Pro Gly Asn Met
            420                 425                 430         
Arg Ala Phe Asn Glu Ala Gly Leu Leu Thr Thr Tyr Asn Pro Arg Lys
        435                 440                 445             
Val Gln Lys Leu Trp Asn Leu Glu Pro Gly Glu Val Gln Pro Gln Thr
    450                 455                 460                 
Leu Gln His His Ile Ile Arg Thr Glu Asp Ile Ser Ser Asp Ile Phe
465                 470                 475                 480 
Arg Arg Arg Tyr Ala Thr Pro Ala Ser Ala Leu Ala Gly Glu Ser Leu
                485                 490                 495     
Glu Lys Arg Leu Thr Asn Glu Ser
            500                 


<210> 6803
<211> 691
<212> PRT
<213> Homo sapiens

<400> 6803
Met Ser Trp Phe Val Asp Leu Ala Gly Lys Ala Glu Asp Leu Leu Asn
 1               5                  10                  15      
Arg Val Asp Gln Gly Ala Ala Thr Ala Leu Ser Arg Lys Asp Asn Ala
            20                  25                  30          
Ser Asn Ile Tyr Ser Lys Asn Thr Asp Tyr Thr Glu Leu His Gln Gln
        35                  40                  45              
Asn Thr Asp Leu Ile Tyr Gln Thr Gly Pro Lys Ser Thr Tyr Ile Ser
    50                  55                  60                  
Ser Ala Ala Asp Asn Ile Arg Asn Gln Lys Ala Thr Ile Leu Ala Gly
65                  70                  75                  80  
Thr Ala Asn Val Lys Val Gly Ser Arg Thr Pro Val Glu Ala Ser His
                85                  90                  95      
Pro Val Glu Asn Ala Ser Val Pro Arg Pro Ser Ser His Phe Val Arg
            100                 105                 110         
Arg Lys Lys Ser Glu Pro Asp Asp Glu Leu Leu Phe Asp Phe Leu Asn
        115                 120                 125             
Ser Ser Gln Lys Glu Pro Thr Gly Arg Val Glu Ile Arg Lys Glu Lys
    130                 135                 140                 
Gly Lys Thr Pro Val Phe Gln Ser Ser Gln Thr Ser Ser Val Ser Ser
145                 150                 155                 160 
Val Asn Pro Ser Val Thr Thr Ile Lys Thr Ile Glu Glu Asn Ser Phe
                165                 170                 175     
Gly Ser Gln Thr His Glu Ala Ala Ser Asn Ser Asp Ser Ser His Glu
            180                 185                 190         
Gly Gln Glu Glu Ser Ser Lys Glu Asn Val Ser Ser Asn Ala Ala Cys
        195                 200                 205             
Pro Asp His Thr Pro Thr Pro Asn Asp Asp Gly Lys Ser His Glu Leu
    210                 215                 220                 
Ser Asn Leu Arg Leu Glu Asn Gln Leu Leu Arg Asn Glu Val Gln Ser
225                 230                 235                 240 
Leu Asn Gln Glu Met Ala Ser Leu Leu Gln Arg Ser Lys Glu Thr Gln
                245                 250                 255     
Glu Glu Leu Asn Lys Ala Arg Ala Arg Val Glu Lys Trp Asn Ala Asp
            260                 265                 270         
His Ser Lys Ser Asp Arg Met Thr Arg Gly Leu Arg Ala Gln Val Asp
        275                 280                 285             
Asp Leu Thr Glu Ala Val Ala Ala Lys Asp Ser Gln Leu Ala Val Leu
    290                 295                 300                 
Lys Val Arg Leu Gln Glu Ala Asp Gln Leu Leu Ser Thr Arg Thr Glu
305                 310                 315                 320 
Ala Leu Glu Ala Leu Gln Ser Glu Lys Ser Arg Ile Met Gln Asp Gln
                325                 330                 335     
Ser Glu Gly Asn Ser Leu Gln Asn Gln Ala Leu Gln Thr Leu Gln Glu
            340                 345                 350         
Arg Leu His Glu Ala Asp Ala Thr Leu Lys Arg Glu Gln Glu Ser Tyr
        355                 360                 365             
Lys Gln Met Gln Ser Glu Phe Ala Ala Arg Leu Asn Lys Val Glu Met
    370                 375                 380                 
Glu Arg Gln Asn Leu Ala Glu Ala Ile Thr Leu Ala Glu Arg Lys Tyr
385                 390                 395                 400 
Ser Asp Glu Lys Lys Arg Val Asp Glu Leu Gln Gln Gln Val Lys Leu
                405                 410                 415     
Tyr Lys Leu Asn Leu Glu Ser Ser Lys Gln Glu Leu Ile Asp Tyr Lys
            420                 425                 430         
Gln Lys Ala Thr Arg Ile Leu Gln Ser Lys Glu Lys Leu Ile Asn Ser
        435                 440                 445             
Leu Lys Glu Gly Ser Gly Phe Glu Gly Leu Asp Ser Ser Thr Ala Ser
    450                 455                 460                 
Ser Met Glu Leu Glu Glu Leu Arg His Glu Lys Glu Met Gln Arg Glu
465                 470                 475                 480 
Glu Ile Gln Lys Leu Met Gly Gln Ile His Gln Leu Arg Ser Glu Leu
                485                 490                 495     
Gln Asp Met Glu Ala Gln Gln Val Asn Glu Ala Glu Ser Ala Arg Glu
            500                 505                 510         
Gln Leu Gln Asp Leu His Asp Gln Ile Ala Gly Gln Lys Ala Ser Lys
        515                 520                 525             
Gln Glu Leu Glu Thr Glu Leu Glu Arg Leu Lys Gln Glu Phe His Tyr
    530                 535                 540                 
Ile Glu Glu Asp Leu Tyr Arg Thr Lys Asn Thr Leu Gln Ser Arg Ile
545                 550                 555                 560 
Lys Asp Arg Asp Glu Glu Ile Gln Lys Leu Arg Asn Gln Leu Thr Asn
                565                 570                 575     
Lys Thr Leu Ser Asn Ser Ser Gln Ser Glu Leu Glu Asn Arg Leu His
            580                 585                 590         
Gln Leu Thr Glu Thr Leu Ile Gln Lys Gln Thr Met Leu Glu Ser Leu
        595                 600                 605             
Ser Thr Glu Lys Asn Ser Leu Val Phe Gln Leu Glu Arg Leu Glu Gln
    610                 615                 620                 
Gln Met Asn Ser Ala Ser Gly Ser Ser Ser Asn Gly Ser Ser Ile Asn
625                 630                 635                 640 
Met Ser Gly Ile Asp Asn Gly Glu Gly Thr Arg Leu Arg Asn Val Pro
                645                 650                 655     
Val Leu Phe Asn Asp Thr Glu Thr Asn Leu Ala Gly Met Tyr Gly Lys
            660                 665                 670         
Val Arg Lys Ala Ala Ser Ser Ile Asp Gln Phe Arg Leu Cys Phe Thr
        675                 680                 685             
Ser Gly Ser
    690     


<210> 6804
<211> 731
<212> PRT
<213> Homo sapiens

<400> 6804
Met Ser Trp Phe Val Asp Leu Ala Gly Lys Ala Glu Asp Leu Leu Asn
 1               5                  10                  15      
Arg Val Asp Gln Gly Ala Ala Thr Ala Leu Ser Arg Lys Asp Asn Ala
            20                  25                  30          
Ser Asn Ile Tyr Ser Lys Asn Thr Asp Tyr Thr Glu Leu His Gln Gln
        35                  40                  45              
Asn Thr Asp Leu Ile Tyr Gln Thr Gly Pro Lys Ser Thr Tyr Ile Ser
    50                  55                  60                  
Ser Ala Ala Asp Asn Ile Arg Asn Gln Lys Ala Thr Ile Leu Ala Gly
65                  70                  75                  80  
Thr Ala Asn Val Lys Val Gly Ser Arg Thr Pro Val Glu Ala Ser His
                85                  90                  95      
Pro Val Glu Asn Ala Ser Val Pro Arg Pro Ser Ser His Phe Val Arg
            100                 105                 110         
Arg Lys Lys Ser Glu Pro Asp Asp Glu Leu Leu Phe Asp Phe Leu Asn
        115                 120                 125             
Ser Ser Gln Lys Glu Pro Thr Gly Arg Val Glu Ile Arg Lys Glu Lys
    130                 135                 140                 
Gly Lys Thr Pro Val Phe Gln Ser Ser Gln Thr Ser Ser Val Ser Ser
145                 150                 155                 160 
Val Asn Pro Ser Val Thr Thr Ile Lys Thr Ile Glu Glu Asn Ser Phe
                165                 170                 175     
Gly Ser Gln Thr His Glu Ala Ala Ser Asn Ser Asp Ser Ser His Glu
            180                 185                 190         
Gly Gln Glu Glu Ser Ser Lys Glu Asn Val Ser Ser Asn Ala Ala Cys
        195                 200                 205             
Pro Asp His Thr Pro Thr Pro Asn Asp Asp Gly Lys Ser His Glu Leu
    210                 215                 220                 
Ser Asn Leu Arg Leu Glu Asn Gln Leu Leu Arg Asn Glu Val Gln Ser
225                 230                 235                 240 
Leu Asn Gln Glu Met Ala Ser Leu Leu Gln Arg Ser Lys Glu Thr Gln
                245                 250                 255     
Glu Glu Leu Asn Lys Ala Arg Ala Arg Val Glu Lys Trp Asn Ala Asp
            260                 265                 270         
His Ser Lys Ser Asp Arg Met Thr Arg Gly Leu Arg Ala Gln Val Asp
        275                 280                 285             
Asp Leu Thr Glu Ala Val Ala Ala Lys Asp Ser Gln Leu Ala Val Leu
    290                 295                 300                 
Lys Val Arg Leu Gln Glu Ala Asp Gln Leu Leu Ser Thr Arg Thr Glu
305                 310                 315                 320 
Ala Leu Glu Ala Leu Gln Ser Glu Lys Ser Arg Ile Met Gln Asp Gln
                325                 330                 335     
Ser Glu Gly Asn Ser Leu Gln Asn Gln Ala Leu Gln Thr Leu Gln Glu
            340                 345                 350         
Arg Leu His Glu Ala Asp Ala Thr Leu Lys Arg Glu Gln Glu Ser Tyr
        355                 360                 365             
Lys Gln Met Gln Ser Glu Phe Ala Ala Arg Leu Asn Lys Val Glu Met
    370                 375                 380                 
Glu Arg Gln Asn Leu Ala Glu Ala Ile Thr Leu Ala Glu Arg Lys Tyr
385                 390                 395                 400 
Ser Asp Glu Lys Lys Arg Val Asp Glu Leu Gln Gln Gln Val Lys Leu
                405                 410                 415     
Tyr Lys Leu Asn Leu Glu Ser Ser Lys Gln Glu Leu Ile Asp Tyr Lys
            420                 425                 430         
Gln Lys Ala Thr Arg Ile Leu Gln Ser Lys Glu Lys Leu Ile Asn Ser
        435                 440                 445             
Leu Lys Glu Gly Ser Gly Phe Glu Gly Leu Asp Ser Ser Thr Ala Ser
    450                 455                 460                 
Ser Met Glu Leu Glu Glu Leu Arg His Glu Lys Glu Met Gln Arg Glu
465                 470                 475                 480 
Glu Ile Gln Lys Leu Met Gly Gln Ile His Gln Leu Arg Ser Glu Leu
                485                 490                 495     
Gln Asp Met Glu Ala Gln Gln Val Asn Glu Ala Glu Ser Ala Arg Glu
            500                 505                 510         
Gln Leu Gln Asp Leu His Asp Gln Ile Ala Gly Gln Lys Ala Ser Lys
        515                 520                 525             
Gln Glu Leu Glu Thr Glu Leu Glu Arg Leu Lys Gln Glu Phe His Tyr
    530                 535                 540                 
Ile Glu Glu Asp Leu Tyr Arg Thr Lys Asn Thr Leu Gln Ser Arg Ile
545                 550                 555                 560 
Lys Asp Arg Asp Glu Glu Ile Gln Lys Leu Arg Asn Gln Leu Thr Asn
                565                 570                 575     
Lys Thr Leu Ser Asn Ser Ser Gln Ser Glu Leu Glu Asn Arg Leu His
            580                 585                 590         
Gln Leu Thr Glu Thr Leu Ile Gln Lys Gln Thr Met Leu Glu Ser Leu
        595                 600                 605             
Ser Thr Glu Lys Asn Ser Leu Val Phe Gln Leu Glu Arg Leu Glu Gln
    610                 615                 620                 
Gln Met Asn Ser Ala Ser Gly Ser Ser Ser Asn Gly Ser Ser Ile Asn
625                 630                 635                 640 
Met Ser Gly Ile Asp Asn Gly Glu Gly Thr Arg Leu Arg Asn Val Pro
                645                 650                 655     
Val Leu Phe Asn Asp Thr Glu Thr Asn Leu Ala Gly Met Tyr Gly Lys
            660                 665                 670         
Val Arg Lys Ala Ala Ser Ser Ile Asp Gln Phe Ser Ile Arg Leu Gly
        675                 680                 685             
Ile Phe Leu Arg Arg Tyr Pro Ile Ala Arg Val Phe Val Ile Ile Tyr
    690                 695                 700                 
Met Ala Leu Leu His Leu Trp Val Met Ile Val Leu Leu Thr Tyr Thr
705                 710                 715                 720 
Pro Glu Met His His Asp Gln Pro Tyr Gly Lys
                725                 730     


<210> 6805
<211> 1099
<212> PRT
<213> Homo sapiens

<400> 6805
Met Ser Leu Asn Asn Ser Ser Asn Val Phe Leu Asp Ser Val Pro Ser
 1               5                  10                  15      
Asn Thr Asn Arg Phe Gln Val Ser Val Ile Asn Glu Asn His Glu Ser
            20                  25                  30          
Ser Ala Ala Ala Asp Asp Asn Thr Asp Pro Pro His Tyr Glu Glu Thr
        35                  40                  45              
Ser Phe Gly Asp Glu Ala Gln Lys Arg Leu Arg Ile Ser Phe Arg Pro
    50                  55                  60                  
Gly Asn Gln Glu Cys Tyr Asp Asn Phe Leu His Ser Gly Glu Thr Ala
65                  70                  75                  80  
Lys Thr Asp Ala Ser Phe His Ala Tyr Asp Ser His Thr Asn Thr Tyr
                85                  90                  95      
Tyr Leu Gln Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Lys Ile
            100                 105                 110         
Glu Tyr Tyr Arg Asn Thr Gly Ser Ile Ser Gly Pro Lys Val Asn Arg
        115                 120                 125             
Pro Ser Leu Leu Glu Ile His Glu Gln Leu Ala Lys Asn Val Ala Val
    130                 135                 140                 
Thr Pro Ser Ser Ala Asp Arg Val Ala Asn Gly Asp Gly Ile Pro Gly
145                 150                 155                 160 
Asp Glu Gln Ala Glu Asn Lys Glu Asp Asp Gln Ala Gly Val Val Lys
                165                 170                 175     
Phe Gly Trp Val Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp
            180                 185                 190         
Gly Val Met Leu Phe Ile Arg Leu Ser Trp Ile Val Gly Glu Ala Gly
        195                 200                 205             
Ile Gly Leu Gly Val Ile Ile Ile Gly Leu Ser Thr Ile Val Thr Thr
    210                 215                 220                 
Ile Thr Gly Met Ser Thr Ser Ala Ile Ala Thr Asn Gly Val Val Arg
225                 230                 235                 240 
Gly Gly Gly Ala Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe
                245                 250                 255     
Gly Gly Ser Ile Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val
            260                 265                 270         
Ala Met Tyr Val Val Gly Phe Ala Glu Thr Val Val Asp Leu Leu Lys
        275                 280                 285             
Glu Ser Asp Ser Met Met Val Asp Pro Thr Asn Asp Ile Arg Ile Ile
    290                 295                 300                 
Gly Ser Ile Thr Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met
305                 310                 315                 320 
Glu Trp Glu Ala Lys Ala Gln Val Ile Leu Leu Val Ile Leu Leu Ile
                325                 330                 335     
Ala Ile Ala Asn Phe Phe Ile Gly Thr Val Ile Pro Ser Asn Asn Glu
            340                 345                 350         
Lys Lys Ser Arg Gly Phe Phe Asn Tyr Gln Ala Ser Ile Phe Ala Glu
        355                 360                 365             
Asn Phe Gly Pro Arg Phe Thr Lys Gly Glu Gly Phe Phe Ser Val Phe
    370                 375                 380                 
Ala Ile Phe Phe Pro Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile
385                 390                 395                 400 
Ser Gly Asp Leu Glu Asp Pro Gln Asp Ala Ile Pro Arg Gly Thr Met
                405                 410                 415     
Leu Ala Ile Phe Ile Thr Thr Val Ala Tyr Leu Gly Val Ala Ile Cys
            420                 425                 430         
Val Gly Ala Cys Val Val Arg Asp Ala Thr Gly Asn Met Asn Asp Thr
        435                 440                 445             
Ile Ile Ser Gly Met Asn Cys Asn Gly Ser Ala Ala Cys Gly Leu Gly
    450                 455                 460                 
Tyr Asp Phe Ser Arg Cys Arg His Glu Pro Cys Gln Tyr Gly Leu Met
465                 470                 475                 480 
Asn Asn Phe Gln Val Met Ser Met Val Ser Gly Phe Gly Pro Leu Ile
                485                 490                 495     
Thr Ala Gly Ile Phe Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu
            500                 505                 510         
Val Ser Ala Pro Lys Val Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr
        515                 520                 525             
Lys Ala Leu Gln Phe Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro
    530                 535                 540                 
Leu Arg Gly Tyr Ile Leu Thr Phe Leu Ile Ala Met Ala Phe Ile Leu
545                 550                 555                 560 
Ile Ala Glu Leu Asn Thr Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu
                565                 570                 575     
Ala Ser Tyr Ala Leu Ile Asn Phe Ser Cys Phe His Ala Ser Tyr Ala
            580                 585                 590         
Lys Ser Pro Gly Trp Arg Pro Ala Tyr Gly Ile Tyr Asn Met Trp Val
        595                 600                 605             
Ser Leu Phe Gly Ala Val Leu Cys Cys Ala Val Met Phe Val Ile Asn
    610                 615                 620                 
Trp Trp Ala Ala Val Ile Thr Tyr Val Ile Glu Phe Phe Leu Tyr Val
625                 630                 635                 640 
Tyr Val Thr Cys Lys Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln
                645                 650                 655     
Ala Leu Ser Tyr Val Ser Ala Leu Asp Asn Ala Leu Glu Leu Thr Thr
            660                 665                 670         
Val Glu Asp His Val Lys Asn Phe Arg Pro Gln Cys Ile Val Leu Thr
        675                 680                 685             
Gly Gly Pro Met Thr Arg Pro Ala Leu Leu Asp Ile Thr His Ala Phe
    690                 695                 700                 
Thr Lys Asn Ser Gly Leu Cys Ile Cys Cys Glu Val Phe Val Gly Pro
705                 710                 715                 720 
Arg Lys Leu Cys Val Lys Glu Met Asn Ser Gly Met Ala Lys Lys Gln
                725                 730                 735     
Ala Trp Leu Ile Lys Asn Lys Ile Lys Ala Phe Tyr Ala Ala Val Ala
            740                 745                 750         
Ala Asp Cys Phe Arg Asp Gly Val Arg Ser Leu Leu Gln Ala Ser Gly
        755                 760                 765             
Leu Gly Arg Met Lys Pro Asn Thr Leu Val Ile Gly Tyr Lys Lys Asn
    770                 775                 780                 
Trp Arg Lys Ala Pro Leu Thr Glu Ile Glu Asn Tyr Val Gly Ile Ile
785                 790                 795                 800 
His Asp Ala Phe Asp Phe Glu Ile Gly Val Val Ile Val Arg Ile Ser
                805                 810                 815     
Gln Gly Phe Asp Ile Ser Gln Val Leu Gln Val Gln Glu Glu Leu Glu
            820                 825                 830         
Arg Leu Glu Gln Glu Arg Leu Ala Leu Glu Ala Thr Ile Lys Asp Asn
        835                 840                 845             
Glu Cys Glu Glu Glu Ser Gly Gly Ile Arg Gly Leu Phe Lys Lys Ala
    850                 855                 860                 
Gly Lys Leu Asn Ile Thr Lys Thr Thr Pro Lys Lys Asp Gly Ser Ile
865                 870                 875                 880 
Asn Thr Ser Gln Ser Met His Val Gly Glu Phe Asn Gln Lys Leu Val
                885                 890                 895     
Glu Ala Ser Thr Gln Phe Lys Lys Lys Gln Glu Lys Gly Thr Ile Asp
            900                 905                 910         
Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro Tyr
        915                 920                 925             
Ile Leu Thr Leu Arg Lys Lys Trp Lys Asp Cys Lys Leu Arg Ile Tyr
    930                 935                 940                 
Val Gly Gly Lys Ile Asn Arg Ile Glu Glu Glu Lys Ile Ala Met Ala
945                 950                 955                 960 
Ser Leu Leu Ser Lys Phe Arg Ile Lys Phe Ala Asp Ile His Ile Ile
                965                 970                 975     
Gly Asp Ile Asn Ile Arg Pro Asn Lys Glu Ser Trp Lys Val Phe Glu
            980                 985                 990         
Glu Met Ile Glu Pro Tyr Arg Leu His Glu Ser Cys Lys Asp Leu Thr
        995                 1000                1005            
Thr Ala Glu Lys Leu Lys Arg Glu Thr Pro Trp Lys Ile Thr Asp Ala
    1010                1015                1020                
Glu Leu Glu Ala Val Lys Glu Lys Ser Tyr Arg Gln Val Arg Leu Asn
1025                1030                1035                1040
Glu Leu Leu Gln Glu His Ser Arg Ala Ala Asn Leu Ile Val Leu Ser
                1045                1050                1055    
Leu Pro Val Ala Arg Lys Gly Ser Ile Ser Asp Leu Leu Tyr Met Ala
            1060                1065                1070        
Trp Leu Glu Ile Leu Thr Lys Asn Leu Pro Pro Val Leu Leu Val Arg
        1075                1080                1085            
Gly Asn His Lys Asn Val Leu Thr Phe Tyr Ser
    1090                1095                


<210> 6806
<211> 1112
<212> PRT
<213> Homo sapiens

<400> 6806
Met Arg Arg Asp Glu Arg Asp Ala Lys Ala Met Arg Ser Leu Gln Pro
 1               5                  10                  15      
Pro Asp Gly Ala Gly Ser Pro Pro Glu Ser Leu Arg Asn Gly Tyr Val
            20                  25                  30          
Lys Ser Cys Val Ser Pro Leu Arg Gln Asp Pro Pro Arg Gly Phe Phe
        35                  40                  45              
Phe His Leu Cys Arg Phe Cys Asn Val Glu Leu Arg Pro Pro Pro Ala
    50                  55                  60                  
Ser Pro Gln Gln Pro Arg Arg Cys Ser Pro Phe Cys Arg Ala Arg Leu
65                  70                  75                  80  
Ser Leu Gly Asp Leu Ala Ala Phe Val Leu Ala Leu Leu Leu Gly Ala
                85                  90                  95      
Glu Pro Glu Ser Trp Ala Ala Gly Ala Ala Trp Leu Arg Thr Leu Leu
            100                 105                 110         
Ser Val Cys Ser His Ser Leu Ser Pro Leu Phe Ser Ile Ala Cys Ala
        115                 120                 125             
Phe Phe Phe Leu Thr Cys Phe Leu Thr Arg Thr Lys Arg Gly Pro Gly
    130                 135                 140                 
Pro Gly Arg Ser Cys Gly Ser Trp Trp Leu Leu Ala Leu Pro Ala Cys
145                 150                 155                 160 
Cys Tyr Leu Gly Asp Phe Leu Val Trp Gln Trp Trp Ser Trp Pro Trp
                165                 170                 175     
Gly Asp Gly Asp Ala Gly Ser Ala Ala Pro His Thr Pro Pro Glu Ala
            180                 185                 190         
Ala Ala Gly Arg Leu Leu Leu Val Leu Ser Cys Val Gly Leu Leu Leu
        195                 200                 205             
Thr Leu Ala His Pro Leu Arg Leu Arg His Cys Val Leu Val Leu Leu
    210                 215                 220                 
Leu Ala Ser Phe Val Trp Trp Val Ser Phe Thr Ser Leu Gly Ser Leu
225                 230                 235                 240 
Pro Ser Ala Leu Arg Pro Leu Leu Ser Gly Leu Val Gly Gly Ala Gly
                245                 250                 255     
Cys Leu Leu Ala Leu Gly Leu Asp His Phe Phe Gln Ile Arg Glu Ala
            260                 265                 270         
Pro Leu His Pro Arg Leu Ser Ser Ala Ala Glu Glu Lys Val Pro Val
        275                 280                 285             
Ile Arg Pro Arg Arg Arg Ser Ser Cys Val Ser Leu Gly Glu Thr Ala
    290                 295                 300                 
Ala Ser Tyr Tyr Gly Ser Cys Lys Ile Phe Arg Arg Pro Ser Leu Pro
305                 310                 315                 320 
Cys Ile Ser Arg Glu Gln Met Ile Leu Trp Asp Trp Asp Leu Lys Gln
                325                 330                 335     
Trp Tyr Lys Pro His Tyr Gln Asn Ser Gly Gly Gly Asn Gly Val Asp
            340                 345                 350         
Leu Ser Val Leu Asn Glu Ala Arg Asn Met Val Ser Asp Leu Leu Thr
        355                 360                 365             
Asp Pro Ser Leu Pro Pro Gln Val Ile Ser Ser Leu Arg Ser Ile Ser
    370                 375                 380                 
Ser Leu Met Gly Ala Phe Ser Gly Ser Cys Arg Pro Lys Ile Asn Pro
385                 390                 395                 400 
Leu Thr Pro Phe Pro Gly Phe Tyr Pro Cys Ser Glu Ile Glu Asp Pro
                405                 410                 415     
Ala Glu Lys Gly Asp Arg Lys Leu Asn Lys Gly Leu Asn Arg Asn Ser
            420                 425                 430         
Leu Pro Thr Pro Gln Leu Arg Arg Ser Ser Gly Thr Ser Gly Leu Leu
        435                 440                 445             
Pro Val Glu Gln Ser Ser Arg Trp Asp Arg Asn Asn Gly Lys Arg Pro
    450                 455                 460                 
His Gln Glu Phe Gly Ile Ser Ser Gln Gly Cys Tyr Leu Asn Gly Pro
465                 470                 475                 480 
Phe Asn Ser Asn Leu Leu Thr Ile Pro Lys Gln Arg Ser Ser Ser Val
                485                 490                 495     
Ser Leu Thr His His Val Gly Leu Arg Arg Ala Gly Val Leu Ser Ser
            500                 505                 510         
Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser Thr Gly Ser
        515                 520                 525             
Leu Thr Asn Arg Ser Pro Ile Glu Phe Pro Asp Thr Ala Asp Phe Leu
    530                 535                 540                 
Asn Lys Pro Ser Val Ile Leu Gln Arg Ser Leu Gly Asn Ala Pro Asn
545                 550                 555                 560 
Thr Pro Asp Phe Tyr Gln Gln Leu Arg Asn Ser Asp Ser Asn Leu Cys
                565                 570                 575     
Asn Ser Cys Gly His Gln Met Leu Lys Tyr Val Ser Thr Ser Glu Ser
            580                 585                 590         
Asp Gly Thr Asp Cys Cys Ser Gly Lys Ser Gly Glu Glu Glu Asn Ile
        595                 600                 605             
Phe Ser Lys Glu Ser Phe Lys Leu Met Glu Thr Gln Gln Glu Glu Glu
    610                 615                 620                 
Thr Glu Lys Lys Asp Ser Arg Lys Leu Phe Gln Glu Gly Asp Lys Trp
625                 630                 635                 640 
Leu Thr Glu Glu Ala Gln Ser Glu Gln Gln Thr Asn Ile Glu Gln Glu
                645                 650                 655     
Val Ser Leu Asp Leu Ile Leu Val Glu Glu Tyr Asp Ser Leu Ile Glu
            660                 665                 670         
Lys Met Ser Asn Trp Asn Phe Pro Ile Phe Glu Leu Val Glu Lys Met
        675                 680                 685             
Gly Glu Lys Ser Gly Arg Ile Leu Ser Gln Val Met Tyr Thr Leu Phe
    690                 695                 700                 
Gln Asp Thr Gly Leu Leu Glu Ile Phe Lys Ile Pro Thr Gln Gln Phe
705                 710                 715                 720 
Met Asn Tyr Phe Arg Ala Leu Glu Asn Gly Tyr Arg Asp Ile Pro Tyr
                725                 730                 735     
His Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu
            740                 745                 750         
Thr Thr Arg Pro Val Pro Gly Leu Gln Gln Ile His Asn Gly Cys Gly
        755                 760                 765             
Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn His Gly Arg Ile
    770                 775                 780                 
Ala Tyr Ile Ser Ser Lys Ser Cys Ser Asn Pro Asp Glu Ser Tyr Gly
785                 790                 795                 800 
Cys Leu Ser Ser Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val
                805                 810                 815     
Ala Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe
            820                 825                 830         
Leu Val Ala Thr Asn Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser
        835                 840                 845             
Val Leu Glu Asn His His Ala Ala Ser Ala Trp Asn Leu Tyr Leu Ser
    850                 855                 860                 
Arg Pro Glu Tyr Asn Phe Leu Leu His Leu Asp His Val Glu Phe Lys
865                 870                 875                 880 
Arg Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys
                885                 890                 895     
Lys His Phe Asp Phe Leu Ala Glu Phe Asn Ala Lys Ala Asn Asp Val
            900                 905                 910         
Asn Ser Asn Gly Ile Glu Trp Ser Asn Glu Asn Asp Arg Leu Leu Val
        915                 920                 925             
Cys Gln Val Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Val
    930                 935                 940                 
Arg Asp Leu His Leu Lys Trp Thr Glu Gly Ile Val Asn Glu Phe Tyr
945                 950                 955                 960 
Glu Gln Gly Asp Glu Glu Ala Asn Leu Gly Leu Pro Ile Ser Pro Phe
                965                 970                 975     
Met Asp Arg Ser Ser Pro Gln Leu Ala Lys Leu Gln Glu Ser Phe Ile
            980                 985                 990         
Thr His Ile Val Gly Pro Leu Cys Asn Ser Tyr Asp Ala Ala Gly Leu
        995                 1000                1005            
Leu Pro Gly Gln Trp Leu Glu Ala Glu Glu Asp Asn Asp Thr Glu Ser
    1010                1015                1020                
Gly Asp Asp Glu Asp Gly Glu Glu Leu Asp Thr Glu Asp Glu Glu Met
1025                1030                1035                1040
Glu Asn Asn Leu Asn Pro Lys Pro Pro Arg Arg Lys Ser Arg Arg Arg
                1045                1050                1055    
Ile Phe Cys Gln Leu Met His His Leu Thr Glu Asn His Lys Ile Trp
            1060                1065                1070        
Lys Glu Ile Val Glu Glu Glu Glu Lys Cys Lys Ala Asp Gly Asn Lys
        1075                1080                1085            
Leu Gln Val Glu Asn Ser Ser Leu Pro Gln Ala Asp Glu Ile Gln Val
    1090                1095                1100                
Ile Glu Glu Ala Asp Glu Glu Glu
1105                1110        


<210> 6807
<211> 3312
<212> PRT
<213> Homo sapiens

<400> 6807
Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Glu Arg Ser Thr
 1               5                  10                  15      
Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu
            20                  25                  30          
Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala
        35                  40                  45              
Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys
    50                  55                  60                  
Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val
65                  70                  75                  80  
Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg
                85                  90                  95      
Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu
            100                 105                 110         
His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly
        115                 120                 125             
Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg
    130                 135                 140                 
Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser
145                 150                 155                 160 
Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu
                165                 170                 175     
Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly
            180                 185                 190         
Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu
        195                 200                 205             
Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly
    210                 215                 220                 
Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly
225                 230                 235                 240 
Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro
                245                 250                 255     
Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala
            260                 265                 270         
Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro
        275                 280                 285             
Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala
    290                 295                 300                 
Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn
305                 310                 315                 320 
Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu
                325                 330                 335     
Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro
            340                 345                 350         
Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met
        355                 360                 365             
Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu
    370                 375                 380                 
Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr
385                 390                 395                 400 
Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr
                405                 410                 415     
Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val
            420                 425                 430         
Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu
        435                 440                 445             
Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro
    450                 455                 460                 
Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala
465                 470                 475                 480 
Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser
                485                 490                 495     
Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val
            500                 505                 510         
Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr
        515                 520                 525             
Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln
    530                 535                 540                 
Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro
545                 550                 555                 560 
His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala
                565                 570                 575     
Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His
            580                 585                 590         
Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu
        595                 600                 605             
Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp
    610                 615                 620                 
Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln
625                 630                 635                 640 
Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe
                645                 650                 655     
Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His
            660                 665                 670         
Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr
        675                 680                 685             
Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala
    690                 695                 700                 
Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu
705                 710                 715                 720 
His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu
                725                 730                 735     
Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn
            740                 745                 750         
Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp
        755                 760                 765             
Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp
    770                 775                 780                 
Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn
785                 790                 795                 800 
Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala
                805                 810                 815     
Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr
            820                 825                 830         
Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile
        835                 840                 845             
Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser
    850                 855                 860                 
Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile
865                 870                 875                 880 
Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu
                885                 890                 895     
Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala
            900                 905                 910         
Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr
        915                 920                 925             
Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr
    930                 935                 940                 
Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln
945                 950                 955                 960 
Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro
                965                 970                 975     
Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala
            980                 985                 990         
Asn Gly Arg Val Gln Tyr Thr Phe Gln Asn Gly Glu Asp Gly Asp Gly
        995                 1000                1005            
Asp Phe Thr Ile Glu Pro Thr Ser Gly Ile Val Arg Thr Val Arg Arg
    1010                1015                1020                
Leu Asp Arg Glu Ala Val Ser Val Tyr Glu Leu Thr Ala Tyr Ala Val
1025                1030                1035                1040
Asp Arg Gly Val Pro Pro Leu Arg Thr Pro Val Ser Ile Gln Val Met
                1045                1050                1055    
Val Gln Asp Val Asn Asp Asn Ala Pro Val Phe Pro Ala Glu Glu Phe
            1060                1065                1070        
Glu Val Arg Val Lys Glu Asn Ser Ile Val Gly Ser Val Val Ala Gln
        1075                1080                1085            
Ile Thr Ala Val Asp Pro Asp Glu Gly Pro Asn Ala His Ile Met Tyr
    1090                1095                1100                
Gln Ile Val Glu Gly Asn Ile Pro Glu Leu Phe Gln Met Asp Ile Phe
1105                1110                1115                1120
Ser Gly Glu Leu Thr Ala Leu Ile Asp Leu Asp Tyr Glu Ala Arg Gln
                1125                1130                1135    
Glu Tyr Val Ile Val Val Gln Ala Thr Ser Ala Pro Leu Val Ser Arg
            1140                1145                1150        
Ala Thr Val His Val Arg Leu Val Asp Gln Asn Asp Asn Ser Pro Val
        1155                1160                1165            
Leu Asn Asn Phe Gln Ile Leu Phe Asn Asn Tyr Val Ser Asn Arg Ser
    1170                1175                1180                
Asp Thr Phe Pro Ser Gly Ile Ile Gly Arg Ile Pro Ala Tyr Asp Pro
1185                1190                1195                1200
Asp Val Ser Asp His Leu Phe Tyr Ser Phe Glu Arg Gly Asn Glu Leu
                1205                1210                1215    
Gln Leu Leu Val Val Asn Gln Thr Ser Gly Glu Leu Arg Leu Ser Arg
            1220                1225                1230        
Lys Leu Asp Asn Asn Arg Pro Leu Val Ala Ser Met Leu Val Thr Val
        1235                1240                1245            
Thr Asp Gly Leu His Ser Val Thr Ala Gln Cys Val Leu Arg Val Val
    1250                1255                1260                
Ile Ile Thr Glu Glu Leu Leu Ala Asn Ser Leu Thr Val Arg Leu Glu
1265                1270                1275                1280
Asn Met Trp Gln Glu Arg Phe Leu Ser Pro Leu Leu Gly Arg Phe Leu
                1285                1290                1295    
Glu Gly Val Ala Ala Val Leu Ala Thr Pro Ala Glu Asp Val Phe Ile
            1300                1305                1310        
Phe Asn Ile Gln Asn Asp Thr Asp Val Gly Gly Thr Val Leu Asn Val
        1315                1320                1325            
Ser Phe Ser Ala Leu Ala Pro Arg Gly Ala Gly Ala Gly Ala Ala Gly
    1330                1335                1340                
Pro Trp Phe Ser Ser Glu Glu Leu Gln Glu Gln Leu Tyr Val Arg Arg
1345                1350                1355                1360
Ala Ala Leu Ala Ala Arg Ser Leu Leu Asp Val Leu Pro Phe Asp Asp
                1365                1370                1375    
Asn Val Cys Leu Arg Glu Pro Cys Glu Asn Tyr Met Lys Cys Val Ser
            1380                1385                1390        
Val Leu Arg Phe Asp Ser Ser Ala Pro Phe Leu Ala Ser Ala Ser Thr
        1395                1400                1405            
Leu Phe Arg Pro Ile Gln Pro Ile Ala Gly Leu Arg Cys Arg Cys Pro
    1410                1415                1420                
Pro Gly Phe Thr Gly Asp Phe Cys Glu Thr Glu Leu Asp Leu Cys Tyr
1425                1430                1435                1440
Ser Asn Pro Cys Arg Asn Gly Gly Ala Cys Ala Arg Arg Glu Gly Gly
                1445                1450                1455    
Tyr Thr Cys Val Cys Arg Pro Arg Phe Thr Gly Glu Asp Cys Glu Leu
            1460                1465                1470        
Asp Thr Glu Ala Gly Arg Cys Val Pro Gly Val Cys Arg Asn Gly Gly
        1475                1480                1485            
Thr Cys Thr Asp Ala Pro Asn Gly Gly Phe Arg Cys Gln Cys Pro Ala
    1490                1495                1500                
Gly Gly Ala Phe Glu Gly Pro Arg Cys Glu Val Ala Ala Arg Ser Phe
1505                1510                1515                1520
Pro Pro Ser Ser Phe Val Met Phe Arg Gly Leu Arg Gln Arg Phe His
                1525                1530                1535    
Leu Thr Leu Ser Leu Ser Phe Ala Thr Val Gln Gln Ser Gly Leu Leu
            1540                1545                1550        
Phe Tyr Asn Gly Arg Leu Asn Glu Lys His Asp Phe Leu Ala Leu Glu
        1555                1560                1565            
Leu Val Ala Gly Gln Val Arg Leu Thr Tyr Ser Thr Gly Glu Ser Asn
    1570                1575                1580                
Thr Val Val Ser Pro Thr Val Pro Gly Gly Leu Ser Asp Gly Gln Trp
1585                1590                1595                1600
His Thr Val His Leu Arg Tyr Tyr Asn Lys Pro Arg Thr Asp Ala Leu
                1605                1610                1615    
Gly Gly Ala Gln Gly Pro Ser Lys Asp Lys Val Ala Val Leu Ser Val
            1620                1625                1630        
Asp Asp Cys Asp Val Ala Val Ala Leu Gln Phe Gly Ala Glu Ile Gly
        1635                1640                1645            
Asn Tyr Ser Cys Ala Ala Ala Gly Val Gln Thr Ser Ser Lys Lys Ser
    1650                1655                1660                
Leu Asp Leu Thr Gly Pro Leu Leu Leu Gly Gly Val Pro Asn Leu Pro
1665                1670                1675                1680
Glu Asn Phe Pro Val Ser His Lys Asp Phe Ile Gly Cys Met Arg Asp
                1685                1690                1695    
Leu His Ile Asp Gly Arg Arg Val Asp Met Ala Ala Phe Val Ala Asn
            1700                1705                1710        
Asn Gly Thr Met Ala Gly Cys Gln Ala Lys Leu His Phe Cys Asp Ser
        1715                1720                1725            
Gly Pro Cys Lys Asn Ser Gly Phe Cys Ser Glu Arg Trp Gly Ser Phe
    1730                1735                1740                
Ser Cys Asp Cys Pro Val Gly Phe Gly Gly Lys Asp Cys Gln Leu Thr
1745                1750                1755                1760
Met Ala His Pro His His Phe Arg Gly Asn Gly Thr Leu Ser Trp Asn
                1765                1770                1775    
Phe Gly Ser Asp Met Ala Val Ser Val Pro Trp Tyr Leu Gly Leu Ala
            1780                1785                1790        
Phe Arg Thr Arg Ala Thr Gln Gly Val Leu Met Gln Val Gln Ala Gly
        1795                1800                1805            
Pro His Ser Thr Leu Leu Cys Gln Leu Asp Arg Gly Leu Leu Ser Val
    1810                1815                1820                
Thr Val Thr Arg Gly Ser Gly Arg Ala Ser His Leu Leu Leu Asp Gln
1825                1830                1835                1840
Val Thr Val Ser Asp Gly Arg Trp His Asp Leu Arg Leu Glu Leu Gln
                1845                1850                1855    
Glu Glu Pro Gly Gly Arg Arg Gly His His Val Leu Met Val Ser Leu
            1860                1865                1870        
Asp Phe Ser Leu Phe Gln Asp Thr Met Ala Val Gly Ser Glu Leu Gln
        1875                1880                1885            
Gly Leu Lys Val Lys Gln Leu His Val Gly Gly Leu Pro Pro Gly Ser
    1890                1895                1900                
Ala Glu Glu Ala Pro Gln Gly Leu Val Gly Cys Ile Gln Gly Val Trp
1905                1910                1915                1920
Leu Gly Ser Thr Pro Ser Gly Ser Pro Ala Leu Leu Pro Pro Ser His
                1925                1930                1935    
Arg Val Asn Ala Glu Pro Gly Cys Val Val Thr Asn Ala Cys Ala Ser
            1940                1945                1950        
Gly Pro Cys Pro Pro His Ala Asp Cys Arg Asp Leu Trp Gln Thr Phe
        1955                1960                1965            
Ser Cys Thr Cys Gln Pro Gly Tyr Tyr Gly Pro Gly Cys Val Asp Ala
    1970                1975                1980                
Cys Leu Leu Asn Pro Cys Gln Asn Gln Gly Ser Cys Arg His Leu Pro
1985                1990                1995                2000
Gly Ala Pro His Gly Tyr Thr Cys Asp Cys Val Gly Gly Tyr Phe Gly
                2005                2010                2015    
His His Cys Glu His Arg Met Asp Gln Gln Cys Pro Arg Gly Trp Trp
            2020                2025                2030        
Gly Ser Pro Thr Cys Gly Pro Cys Asn Cys Asp Val His Lys Gly Phe
        2035                2040                2045            
Asp Pro Asn Cys Asn Lys Thr Asn Gly Gln Cys His Cys Lys Glu Phe
    2050                2055                2060                
His Tyr Arg Pro Arg Gly Ser Asp Ser Cys Leu Pro Cys Asp Cys Tyr
2065                2070                2075                2080
Pro Val Gly Ser Thr Ser Arg Ser Cys Ala Pro His Ser Gly Gln Cys
                2085                2090                2095    
Pro Cys Arg Pro Gly Ala Leu Gly Arg Gln Cys Asn Ser Cys Asp Ser
            2100                2105                2110        
Pro Phe Ala Glu Val Thr Ala Ser Gly Cys Arg Val Leu Tyr Asp Ala
        2115                2120                2125            
Cys Pro Lys Ser Leu Arg Ser Gly Val Trp Trp Pro Gln Thr Lys Phe
    2130                2135                2140                
Gly Val Leu Ala Thr Val Pro Cys Pro Arg Gly Ala Leu Gly Ala Ala
2145                2150                2155                2160
Val Arg Leu Cys Asp Glu Ala Gln Gly Trp Leu Glu Pro Asp Leu Phe
                2165                2170                2175    
Asn Cys Thr Ser Pro Ala Phe Arg Glu Leu Ser Leu Leu Leu Asp Gly
            2180                2185                2190        
Leu Glu Leu Asn Lys Thr Ala Leu Asp Thr Met Glu Ala Lys Lys Leu
        2195                2200                2205            
Ala Gln Arg Leu Arg Glu Val Thr Gly His Thr Asp His Tyr Phe Ser
    2210                2215                2220                
Gln Asp Val Arg Val Thr Ala Arg Leu Leu Ala His Leu Leu Ala Phe
2225                2230                2235                2240
Glu Ser His Gln Gln Gly Phe Gly Leu Thr Ala Thr Gln Asp Ala His
                2245                2250                2255    
Phe Asn Glu Asn Leu Leu Trp Ala Gly Ser Ala Leu Leu Ala Pro Glu
            2260                2265                2270        
Thr Gly Asp Leu Trp Ala Ala Leu Gly Gln Arg Ala Pro Gly Gly Ser
        2275                2280                2285            
Pro Gly Ser Ala Gly Leu Val Arg His Leu Glu Glu Tyr Ala Ala Thr
    2290                2295                2300                
Leu Ala Arg Asn Met Glu Leu Thr Tyr Leu Asn Pro Met Gly Leu Val
2305                2310                2315                2320
Thr Pro Asn Ile Met Leu Ser Ile Asp Arg Met Glu His Pro Ser Ser
                2325                2330                2335    
Pro Arg Gly Ala Arg Arg Tyr Pro Arg Tyr His Ser Asn Leu Phe Arg
            2340                2345                2350        
Gly Gln Asp Ala Trp Asp Pro His Thr His Val Leu Leu Pro Ser Gln
        2355                2360                2365            
Ser Pro Arg Pro Ser Pro Ser Glu Val Leu Pro Thr Ser Ser Ser Ile
    2370                2375                2380                
Glu Asn Ser Thr Thr Ser Ser Val Val Pro Pro Pro Ala Pro Pro Glu
2385                2390                2395                2400
Pro Glu Pro Gly Ile Ser Ile Ile Ile Leu Leu Val Tyr Arg Thr Leu
                2405                2410                2415    
Gly Gly Leu Leu Pro Ala Gln Phe Gln Ala Glu Arg Arg Gly Ala Arg
            2420                2425                2430        
Leu Pro Gln Asn Pro Val Met Asn Ser Pro Val Val Ser Val Ala Val
        2435                2440                2445            
Phe His Gly Arg Asn Phe Leu Arg Gly Ile Leu Glu Ser Pro Ile Ser
    2450                2455                2460                
Leu Glu Phe Arg Leu Leu Gln Thr Ala Asn Arg Ser Lys Ala Ile Cys
2465                2470                2475                2480
Val Gln Trp Asp Pro Pro Gly Leu Ala Glu Gln His Gly Val Trp Thr
                2485                2490                2495    
Ala Arg Asp Cys Glu Leu Val His Arg Asn Gly Ser His Ala Arg Cys
            2500                2505                2510        
Arg Cys Ser Arg Thr Gly Thr Phe Gly Val Leu Met Asp Ala Ser Pro
        2515                2520                2525            
Arg Glu Arg Leu Glu Gly Asp Leu Glu Leu Leu Ala Val Phe Thr His
    2530                2535                2540                
Val Val Val Ala Val Ser Val Ala Ala Leu Val Leu Thr Ala Ala Ile
2545                2550                2555                2560
Leu Leu Ser Leu Arg Ser Leu Lys Ser Asn Val Arg Gly Ile His Ala
                2565                2570                2575    
Asn Val Ala Ala Ala Leu Gly Val Ala Glu Leu Leu Phe Leu Leu Gly
            2580                2585                2590        
Ile His Arg Thr His Asn Gln Leu Val Cys Thr Ala Val Ala Ile Leu
        2595                2600                2605            
Leu His Tyr Phe Phe Leu Ser Thr Phe Ala Trp Leu Phe Val Gln Gly
    2610                2615                2620                
Leu His Leu Tyr Arg Met Gln Val Glu Pro Arg Asn Val Asp Arg Gly
2625                2630                2635                2640
Ala Met Arg Phe Tyr His Ala Leu Gly Trp Gly Val Pro Ala Val Leu
                2645                2650                2655    
Leu Gly Leu Ala Val Gly Leu Asp Pro Glu Gly Tyr Gly Asn Pro Asp
            2660                2665                2670        
Phe Cys Trp Ile Ser Val His Glu Pro Leu Ile Trp Ser Phe Ala Gly
        2675                2680                2685            
Pro Val Val Leu Val Ile Val Met Asn Gly Thr Met Phe Leu Leu Ala
    2690                2695                2700                
Ala Arg Thr Ser Cys Ser Thr Gly Gln Arg Glu Ala Lys Lys Thr Ser
2705                2710                2715                2720
Ala Leu Thr Leu Arg Ser Ser Phe Leu Leu Leu Leu Leu Val Ser Ala
                2725                2730                2735    
Ser Trp Leu Phe Gly Leu Leu Ala Val Asn His Ser Ile Leu Ala Phe
            2740                2745                2750        
His Tyr Leu His Ala Gly Leu Cys Gly Leu Gln Gly Leu Ala Val Leu
        2755                2760                2765            
Leu Leu Phe Cys Val Leu Asn Ala Asp Ala Arg Ala Ala Trp Met Pro
    2770                2775                2780                
Ala Cys Leu Gly Arg Lys Ala Ala Pro Glu Glu Ala Arg Pro Ala Pro
2785                2790                2795                2800
Gly Leu Gly Pro Gly Ala Tyr Asn Asn Thr Ala Leu Phe Glu Glu Ser
                2805                2810                2815    
Gly Leu Ile Arg Ile Thr Leu Gly Ala Ser Thr Val Ser Ser Val Ser
            2820                2825                2830        
Ser Ala Arg Ser Gly Arg Thr Gln Asp Gln Asp Ser Gln Arg Gly Arg
        2835                2840                2845            
Ser Tyr Leu Arg Asp Asn Val Leu Val Arg His Gly Ser Ala Ala Asp
    2850                2855                2860                
His Thr Asp His Ser Leu Gln Ala His Ala Gly Pro Thr Asp Leu Asp
2865                2870                2875                2880
Val Ala Met Phe His Arg Asp Ala Gly Ala Asp Ser Asp Ser Asp Ser
                2885                2890                2895    
Asp Leu Ser Leu Glu Glu Glu Arg Ser Leu Ser Ile Pro Ser Ser Glu
            2900                2905                2910        
Ser Glu Asp Asn Gly Arg Thr Arg Gly Arg Phe Gln Arg Pro Leu Cys
        2915                2920                2925            
Arg Ala Ala Gln Ser Glu Arg Leu Leu Thr His Pro Lys Asp Val Asp
    2930                2935                2940                
Gly Asn Asp Leu Leu Ser Tyr Trp Pro Ala Leu Gly Glu Cys Glu Ala
2945                2950                2955                2960
Ala Pro Cys Ala Leu Gln Thr Trp Gly Ser Glu Arg Arg Leu Gly Leu
                2965                2970                2975    
Asp Thr Ser Lys Asp Ala Ala Asn Asn Asn Gln Pro Asp Pro Ala Leu
            2980                2985                2990        
Thr Ser Gly Asp Glu Thr Ser Leu Gly Arg Ala Gln Arg Gln Arg Lys
        2995                3000                3005            
Gly Ile Leu Lys Asn Arg Leu Gln Tyr Pro Leu Val Pro Gln Thr Arg
    3010                3015                3020                
Gly Ala Pro Glu Leu Ser Trp Cys Arg Ala Ala Thr Leu Gly His Arg
3025                3030                3035                3040
Ala Val Pro Ala Ala Ser Tyr Gly Arg Ile Tyr Ala Gly Gly Gly Thr
                3045                3050                3055    
Gly Ser Leu Ser Gln Pro Ala Ser Arg Tyr Ser Ser Arg Glu Gln Leu
            3060                3065                3070        
Asp Leu Leu Leu Arg Arg Gln Leu Ser Arg Glu Arg Leu Glu Glu Ala
        3075                3080                3085            
Pro Ala Pro Val Leu Arg Pro Leu Ser Arg Pro Gly Ser Gln Glu Cys
    3090                3095                3100                
Met Asp Ala Ala Pro Gly Arg Leu Glu Pro Lys Asp Arg Gly Ser Thr
3105                3110                3115                3120
Leu Pro Arg Arg Gln Pro Pro Arg Asp Tyr Pro Gly Ala Met Ala Gly
                3125                3130                3135    
Arg Phe Gly Ser Arg Asp Ala Leu Asp Leu Gly Ala Pro Arg Glu Trp
            3140                3145                3150        
Leu Ser Thr Leu Pro Pro Pro Arg Arg Thr Arg Asp Leu Asp Pro Gln
        3155                3160                3165            
Pro Pro Pro Leu Pro Leu Ser Pro Gln Arg Gln Leu Ser Arg Asp Pro
    3170                3175                3180                
Leu Leu Pro Ser Arg Pro Leu Asp Ser Leu Ser Arg Ser Ser Asn Ser
3185                3190                3195                3200
Arg Glu Gln Leu Asp Gln Val Pro Ser Arg His Pro Ser Arg Glu Ala
                3205                3210                3215    
Leu Gly Pro Leu Pro Gln Leu Leu Arg Ala Arg Glu Asp Ser Val Ser
            3220                3225                3230        
Gly Pro Ser His Gly Pro Ser Thr Glu Gln Leu Asp Ile Leu Ser Ser
        3235                3240                3245            
Ile Leu Ala Ser Phe Asn Ser Ser Ala Leu Ser Ser Val Gln Ser Ser
    3250                3255                3260                
Ser Thr Pro Leu Gly Pro His Thr Thr Ala Thr Pro Ser Ala Thr Ala
3265                3270                3275                3280
Ser Val Leu Gly Pro Ser Thr Pro Arg Ser Ala Thr Ser His Ser Ile
                3285                3290                3295    
Ser Glu Leu Ser Pro Asp Ser Glu Val Pro Arg Ser Glu Gly His Ser
            3300                3305                3310        


<210> 6808
<211> 278
<212> PRT
<213> Homo sapiens

<400> 6808
Ala Lys Gln Ser Met Ala Gly Ile Pro Gly Arg Glu Ser Asn Ala Pro
 1               5                  10                  15      
Ser Val Pro Thr Val Ser Leu Leu Pro Gly Ala Pro Gly Gly Asn Ala
            20                  25                  30          
Ser Ser Arg Thr Glu Ala Gln Val Pro Asn Gly Gln Gly Thr Pro Arg
        35                  40                  45              
Gly Leu Cys Leu Phe Lys Ser Gly Phe Pro Gly Pro Ser Arg Gln Ser
    50                  55                  60                  
Ala Pro Arg Ala Ala Arg Gly Pro Thr Pro Arg Thr Glu Glu Ala Ala
65                  70                  75                  80  
Trp Ala Ala Met Ala Leu Thr Phe Leu Leu Val Leu Leu Thr Leu Ala
                85                  90                  95      
Thr Leu Cys Thr Arg Leu His Arg Asn Phe Arg Arg Gly Glu Ser Ile
            100                 105                 110         
Tyr Trp Gly Pro Thr Ala Asp Ser Gln Asp Thr Val Ala Gly Glu Glu
        115                 120                 125             
Phe Pro Pro Tyr Pro Thr Arg Gly Pro Arg Pro Thr Ser Arg Arg Pro
    130                 135                 140                 
Ala Ala Pro Arg Ser Phe Pro Ala Leu Pro Pro Leu Thr Ala Arg Arg
145                 150                 155                 160 
Pro Ala His Ser Cys Ala Glu Ala Glu Ala Ala Ala Ala Ser Arg Arg
                165                 170                 175     
Val Lys Arg Ser Pro Glu Thr Leu Leu Pro Pro Thr Arg Thr Ala Ala
            180                 185                 190         
Arg Lys Ala Arg Ala Arg Ser Asp Gly Leu Asp Leu Pro Leu Trp Arg
        195                 200                 205             
Ala Ala Pro Pro Ala Pro Arg Pro Arg Pro Leu Pro Arg Gly Pro Arg
    210                 215                 220                 
Ala Gly Ala Pro Trp Trp Arg Trp Arg Gly Thr Gly Arg Ala Leu Arg
225                 230                 235                 240 
Gly Leu Ser Ser Leu Leu Val Ala Glu Trp Ala Ala Lys Gly Arg Lys
                245                 250                 255     
Gly Ala Ala Ser Ala Ser Leu Ala Lys Thr Pro Phe Leu Ile Lys Leu
            260                 265                 270         
Phe Leu Val Lys Lys Lys
        275             


<210> 6809
<211> 393
<212> PRT
<213> Homo sapiens

<400> 6809
Met Ala Pro Pro Pro Pro Ser Pro Gln Leu Leu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Ala Arg Leu Leu Gly Pro Ser Glu Val Met Ala Gly Pro Ala Glu Glu
            20                  25                  30          
Ala Gly Ala His Cys Pro Glu Ser Leu Trp Pro Leu Pro Pro Gln Val
        35                  40                  45              
Ser Pro Arg Val Thr Tyr Thr Arg Val Ser Pro Gly Gln Ala Glu Asp
    50                  55                  60                  
Val Thr Phe Leu Tyr His Pro Cys Ala His Pro Trp Leu Lys Leu Gln
65                  70                  75                  80  
Leu Ala Leu Leu Ala Tyr Ala Cys Met Ala Asn Pro Ser Leu Thr Pro
                85                  90                  95      
Asp Phe Ser Leu Thr Gln Asp Arg Pro Leu Val Leu Thr Ala Trp Gly
            100                 105                 110         
Leu Ala Leu Glu Met Ala Trp Val Glu Pro Ala Trp Ala Ala His Trp
        115                 120                 125             
Leu Met Arg Arg Arg Arg Arg Lys Gln Arg Lys Lys Lys Ala Trp Ile
    130                 135                 140                 
Tyr Cys Glu Ser Leu Ser Gly Pro Ala Pro Ser Glu Pro Thr Pro Gly
145                 150                 155                 160 
Arg Gly Arg Leu Cys Arg Arg Gly Cys Val Gln Ala Leu Ala Leu Ala
                165                 170                 175     
Phe Ala Leu Arg Ser Trp Arg Pro Pro Gly Thr Glu Val Thr Ser Gln
            180                 185                 190         
Gly Pro Arg Gln Pro Ser Ser Ser Gly Ala Lys Arg Arg Arg Leu Arg
        195                 200                 205             
Ala Ala Leu Gly Pro Gln Pro Thr Arg Ser Ala Leu Arg Phe Pro Ser
    210                 215                 220                 
Ala Ser Pro Gly Ser Leu Lys Ala Lys Gln Ser Met Ala Gly Ile Pro
225                 230                 235                 240 
Gly Arg Glu Ser Asn Ala Pro Ser Val Pro Thr Val Ser Leu Leu Pro
                245                 250                 255     
Gly Ala Pro Gly Gly Asn Ala Ser Ser Arg Thr Glu Ala Gln Val Pro
            260                 265                 270         
Asn Gly Gln Gly Ser Pro Gly Gly Cys Val Cys Ser Ser Gln Ala Ser
        275                 280                 285             
Pro Ala Pro Arg Ala Ala Ala Pro Pro Arg Ala Ala Arg Gly Pro Thr
    290                 295                 300                 
Pro Arg Thr Glu Glu Ala Ala Trp Ala Ala Met Ala Leu Thr Phe Leu
305                 310                 315                 320 
Leu Val Leu Leu Thr Leu Ala Thr Leu Cys Thr Arg Leu His Arg Asn
                325                 330                 335     
Phe Arg Arg Gly Glu Ser Ile Tyr Trp Gly Pro Thr Ala Asp Ser Gln
            340                 345                 350         
Asp Thr Val Ala Ala Val Leu Lys Arg Arg Leu Leu Gln Pro Ser Arg
        355                 360                 365             
Arg Val Lys Arg Ser Arg Arg Arg Pro Leu Leu Pro Pro Thr Pro Asp
    370                 375                 380                 
Ser Gly Pro Glu Gly Glu Ser Ser Glu
385                 390             


<210> 6810
<211> 356
<212> PRT
<213> Homo sapiens

<400> 6810
Met Ala Asp Cys Arg Arg Cys Arg Ser Gln Arg Arg Ser His Cys Cys
 1               5                  10                  15      
Gln Asp Arg Arg Leu Arg Ala Lys Thr His Ser Val Glu Thr Pro Tyr
            20                  25                  30          
Gly Ser Val Thr Phe Thr Val Tyr Gly Thr Pro Lys Pro Lys Arg Pro
        35                  40                  45              
Ala Ile Leu Thr Tyr His Asp Val Gly Leu Asn Tyr Lys Ser Cys Phe
    50                  55                  60                  
Gln Pro Leu Phe Gln Phe Glu Asp Met Gln Glu Ile Ile Gln Asn Phe
65                  70                  75                  80  
Val Arg Val His Val Asp Ala Pro Gly Met Glu Glu Gly Ala Pro Val
                85                  90                  95      
Phe Pro Leu Gly Tyr Gln Tyr Pro Ser Leu Asp Gln Leu Ala Asp Met
            100                 105                 110         
Ile Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser Thr Ile Ile Gly Val
        115                 120                 125             
Gly Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg Tyr Ala Leu Asn His
    130                 135                 140                 
Pro Asp Thr Val Glu Gly Leu Val Leu Ile Asn Ile Asp Pro Asn Ala
145                 150                 155                 160 
Lys Gly Trp Met Asp Trp Ala Ala His Lys Leu Thr Gly Leu Thr Ser
                165                 170                 175     
Ser Ile Pro Glu Met Ile Leu Gly His Leu Phe Ser Gln Glu Glu Leu
            180                 185                 190         
Ser Gly Asn Ser Glu Leu Ile Gln Lys Tyr Arg Asn Ile Ile Thr His
        195                 200                 205             
Ala Pro Asn Leu Asp Asn Ile Glu Leu Tyr Trp Asn Ser Tyr Asn Asn
    210                 215                 220                 
Arg Arg Asp Leu Asn Phe Glu Arg Gly Gly Asp Ile Thr Leu Arg Cys
225                 230                 235                 240 
Pro Val Met Leu Val Val Gly Asp Gln Ala Pro His Glu Asp Ala Val
                245                 250                 255     
Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Gln Thr Ser Phe Leu Lys
            260                 265                 270         
Met Ala Asp Ser Gly Gly Gln Pro Gln Leu Thr Gln Pro Gly Lys Leu
        275                 280                 285             
Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Met Ala Ser
    290                 295                 300                 
Ser Cys Met Thr Arg Leu Ser Arg Ser Arg Thr Ala Ser Leu Thr Ser
305                 310                 315                 320 
Ala Ala Ser Val Asp Gly Asn Arg Ser Arg Ser Arg Thr Leu Ser Gln
                325                 330                 335     
Ser Ser Glu Ser Gly Thr Leu Ser Ser Gly Pro Pro Gly His Thr Met
            340                 345                 350         
Glu Val Ser Cys
        355     


<210> 6811
<211> 360
<212> PRT
<213> Homo sapiens

<400> 6811
Met Ala Glu Leu Gln Glu Val Gln Ile Thr Glu Glu Lys Pro Leu Leu
 1               5                  10                  15      
Pro Gly Gln Thr Pro Glu Ala Ala Lys Glu Ala Glu Leu Ala Ala Arg
            20                  25                  30          
Ile Leu Leu Asp Gln Gly Gln Thr His Ser Val Glu Thr Pro Tyr Gly
        35                  40                  45              
Ser Val Thr Phe Thr Val Tyr Gly Thr Pro Lys Pro Lys Arg Pro Ala
    50                  55                  60                  
Ile Leu Thr Tyr His Asp Val Gly Leu Asn Tyr Lys Ser Cys Phe Gln
65                  70                  75                  80  
Pro Leu Phe Gln Phe Glu Asp Met Gln Glu Ile Ile Gln Asn Phe Val
                85                  90                  95      
Arg Val His Val Asp Ala Pro Gly Met Glu Glu Gly Ala Pro Val Phe
            100                 105                 110         
Pro Leu Gly Tyr Gln Tyr Pro Ser Leu Asp Gln Leu Ala Asp Met Ile
        115                 120                 125             
Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser Thr Ile Ile Gly Val Gly
    130                 135                 140                 
Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg Tyr Ala Leu Asn His Pro
145                 150                 155                 160 
Asp Thr Val Glu Gly Leu Val Leu Ile Asn Ile Asp Pro Asn Ala Lys
                165                 170                 175     
Gly Trp Met Asp Trp Ala Ala His Lys Leu Thr Gly Leu Thr Ser Ser
            180                 185                 190         
Ile Pro Glu Met Ile Leu Gly His Leu Phe Ser Gln Glu Glu Leu Ser
        195                 200                 205             
Gly Asn Ser Glu Leu Ile Gln Lys Tyr Arg Asn Ile Ile Thr His Ala
    210                 215                 220                 
Pro Asn Leu Asp Asn Ile Glu Leu Tyr Trp Asn Ser Tyr Asn Asn Arg
225                 230                 235                 240 
Arg Asp Leu Asn Phe Glu Arg Gly Gly Asp Ile Thr Leu Arg Cys Pro
                245                 250                 255     
Val Met Leu Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Gln Thr
            260                 265                 270         
Ser Phe Leu Lys Met Ala Asp Ser Gly Gly Gln Pro Gln Leu Thr Gln
        275                 280                 285             
Pro Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly
    290                 295                 300                 
Tyr Met Ala Ser Ser Cys Met Thr Arg Leu Ser Arg Ser Arg Thr Ala
305                 310                 315                 320 
Ser Leu Thr Ser Ala Ala Ser Val Asp Gly Asn Arg Ser Arg Ser Arg
                325                 330                 335     
Thr Leu Ser Gln Ser Ser Glu Ser Gly Thr Leu Ser Ser Gly Pro Pro
            340                 345                 350         
Gly His Thr Met Glu Val Ser Cys
        355                 360 


<210> 6812
<211> 362
<212> PRT
<213> Homo sapiens

<400> 6812
Cys Arg Arg Cys Arg Ser Gln Arg Arg Ser His Cys Cys Gln Asp Arg
 1               5                  10                  15      
Arg Leu Arg Arg Pro Ser Ser Trp Cys Pro Val Phe Leu Gln Thr His
            20                  25                  30          
Ser Val Glu Thr Pro Tyr Gly Ser Val Thr Phe Thr Val Tyr Gly Thr
        35                  40                  45              
Pro Lys Pro Lys Arg Pro Ala Ile Leu Thr Tyr His Asp Val Gly Leu
    50                  55                  60                  
Asn Tyr Lys Ser Cys Phe Gln Pro Leu Phe Gln Phe Glu Asp Met Gln
65                  70                  75                  80  
Glu Ile Ile Gln Asn Phe Val Arg Val His Val Asp Ala Pro Gly Met
                85                  90                  95      
Glu Glu Gly Ala Pro Val Phe Pro Leu Gly Tyr Gln Tyr Pro Ser Leu
            100                 105                 110         
Asp Gln Leu Ala Asp Met Ile Pro Cys Val Leu Gln Tyr Leu Asn Phe
        115                 120                 125             
Ser Thr Ile Ile Gly Val Gly Val Gly Ala Gly Ala Tyr Ile Leu Ala
    130                 135                 140                 
Arg Tyr Ala Leu Asn His Pro Asp Thr Val Glu Gly Leu Val Leu Ile
145                 150                 155                 160 
Asn Ile Asp Pro Asn Ala Lys Gly Trp Met Asp Trp Ala Ala His Lys
                165                 170                 175     
Leu Thr Gly Leu Thr Ser Ser Ile Pro Glu Met Ile Leu Gly His Leu
            180                 185                 190         
Phe Ser Gln Glu Glu Leu Ser Gly Asn Ser Glu Leu Ile Gln Lys Tyr
        195                 200                 205             
Arg Asn Ile Ile Thr His Ala Pro Asn Leu Asp Asn Ile Glu Leu Tyr
    210                 215                 220                 
Trp Asn Ser Tyr Asn Asn Arg Arg Asp Leu Asn Phe Glu Arg Gly Gly
225                 230                 235                 240 
Asp Ile Thr Leu Arg Cys Pro Val Met Leu Val Val Gly Asp Gln Ala
                245                 250                 255     
Pro His Glu Asp Ala Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr
            260                 265                 270         
Gln Thr Ser Phe Leu Lys Met Ala Asp Ser Gly Gly Gln Pro Gln Leu
        275                 280                 285             
Thr Gln Pro Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly
    290                 295                 300                 
Met Gly Tyr Met Ala Ser Ser Cys Met Thr Arg Leu Ser Arg Ser Arg
305                 310                 315                 320 
Thr Ala Ser Leu Thr Ser Ala Ala Ser Val Asp Gly Asn Arg Ser Arg
                325                 330                 335     
Ser Arg Thr Leu Ser Gln Ser Ser Glu Ser Gly Thr Leu Ser Ser Gly
            340                 345                 350         
Pro Pro Gly His Thr Met Glu Val Ser Cys
        355                 360         


<210> 6813
<211> 332
<212> PRT
<213> Homo sapiens

<400> 6813
Cys Gln Ala Thr Met Ala Glu Leu Gln Glu Val Gln Ile Thr Glu Glu
 1               5                  10                  15      
Lys Pro Leu Leu Pro Gly Gln Thr Pro Glu Ala Ala Lys Thr His Ser
            20                  25                  30          
Val Glu Thr Pro Tyr Gly Ser Val Thr Phe Thr Val Tyr Gly Thr Pro
        35                  40                  45              
Lys Pro Lys Arg Pro Ala Ile Leu Thr Tyr His Asp Val Gly Leu Asn
    50                  55                  60                  
Tyr Lys Ser Cys Phe Gln Pro Leu Phe Gln Phe Glu Asp Met Gln Glu
65                  70                  75                  80  
Ile Ile Gln Asn Phe Val Arg Val His Val Asp Ala Pro Gly Met Glu
                85                  90                  95      
Glu Gly Ala Pro Val Phe Pro Leu Gly Tyr Gln Tyr Pro Ser Leu Asp
            100                 105                 110         
Gln Leu Ala Asp Met Ile Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser
        115                 120                 125             
Thr Ile Ile Gly Val Gly Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg
    130                 135                 140                 
Tyr Ala Leu Thr Gly Leu Thr Ser Ser Ile Pro Glu Met Ile Leu Gly
145                 150                 155                 160 
His Leu Phe Ser Gln Glu Glu Leu Ser Gly Asn Ser Glu Leu Ile Gln
                165                 170                 175     
Lys Tyr Arg Asn Ile Ile Thr His Ala Pro Asn Leu Asp Asn Ile Glu
            180                 185                 190         
Leu Tyr Trp Asn Ser Tyr Asn Asn Arg Arg Asp Leu Asn Phe Glu Arg
        195                 200                 205             
Gly Gly Asp Ile Thr Leu Arg Cys Pro Val Met Leu Val Val Gly Asp
    210                 215                 220                 
Gln Ala Pro His Glu Asp Ala Val Val Glu Cys Asn Ser Lys Leu Asp
225                 230                 235                 240 
Pro Thr Gln Thr Ser Phe Leu Lys Met Ala Asp Ser Gly Gly Gln Pro
                245                 250                 255     
Gln Leu Thr Gln Pro Gly Lys Leu Thr Glu Ala Phe Lys Tyr Phe Leu
            260                 265                 270         
Gln Gly Met Gly Tyr Met Ala Ser Ser Cys Met Thr Arg Leu Ser Arg
        275                 280                 285             
Ser Arg Thr Ala Ser Leu Thr Ser Ala Ala Ser Val Asp Gly Asn Arg
    290                 295                 300                 
Ser Arg Ser Arg Thr Leu Ser Gln Ser Ser Glu Ser Gly Thr Leu Ser
305                 310                 315                 320 
Ser Gly Pro Pro Gly His Thr Met Glu Val Ser Cys
                325                 330         


<210> 6814
<211> 357
<212> PRT
<213> Homo sapiens

<400> 6814
Met Ala Glu Leu Gln Glu Val Gln Ile Thr Glu Glu Lys Pro Leu Leu
 1               5                  10                  15      
Pro Gly Gln Thr Pro Glu Ala Ala Lys Thr His Ser Val Glu Thr Pro
            20                  25                  30          
Tyr Gly Ser Val Thr Phe Thr Val Tyr Gly Thr Pro Lys Pro Lys Arg
        35                  40                  45              
Pro Ala Ile Leu Thr Tyr His Asp Val Gly Leu Asn Tyr Lys Ser Cys
    50                  55                  60                  
Phe Gln Pro Leu Phe Gln Phe Glu Asp Met Gln Glu Ile Ile Gln Asn
65                  70                  75                  80  
Phe Val Arg Val His Val Asp Ala Pro Gly Met Glu Glu Gly Ala Pro
                85                  90                  95      
Val Phe Pro Leu Gly Tyr Gln Tyr Pro Ser Leu Asp Gln Leu Ala Asp
            100                 105                 110         
Met Ile Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser Thr Ile Ile Gly
        115                 120                 125             
Val Gly Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg Tyr Ala Leu Asn
    130                 135                 140                 
His Pro Asp Thr Val Glu Gly Leu Val Leu Ile Asn Ile Asp Pro Asn
145                 150                 155                 160 
Ala Lys Gly Trp Met Asp Trp Ala Ala His Lys Leu Thr Gly Leu Thr
                165                 170                 175     
Ser Ser Ile Pro Glu Met Ile Leu Gly His Leu Phe Ser Gln Glu Glu
            180                 185                 190         
Leu Ser Gly Asn Ser Glu Leu Ile Gln Lys Tyr Arg Asn Ile Ile Thr
        195                 200                 205             
His Ala Pro Asn Leu Asp Asn Ile Glu Leu Tyr Trp Asn Ser Tyr Asn
    210                 215                 220                 
Asn Arg Arg Asp Leu Asn Phe Glu Arg Gly Gly Asp Ile Thr Leu Arg
225                 230                 235                 240 
Cys Pro Val Met Leu Val Val Gly Asp Gln Ala Pro His Glu Asp Ala
                245                 250                 255     
Val Val Glu Cys Asn Ser Lys Leu Asp Pro Thr Gln Thr Ser Phe Leu
            260                 265                 270         
Lys Met Ala Asp Ser Gly Gly Gln Pro Gln Leu Thr Gln Pro Gly Lys
        275                 280                 285             
Leu Thr Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Met Ala
    290                 295                 300                 
Ser Ser Cys Met Thr Arg Leu Ser Arg Ser Arg Thr Ala Ser Leu Thr
305                 310                 315                 320 
Ser Ala Ala Ser Val Asp Gly Asn Arg Ser Arg Ser Arg Thr Leu Ser
                325                 330                 335     
Gln Ser Ser Glu Ser Gly Thr Leu Ser Ser Gly Pro Pro Gly His Thr
            340                 345                 350         
Met Glu Val Ser Cys
        355         


<210> 6815
<211> 371
<212> PRT
<213> Homo sapiens

<400> 6815
Met Ala Glu Leu Gln Glu Val Gln Ile Thr Glu Glu Lys Pro Leu Leu
 1               5                  10                  15      
Pro Gly Gln Thr Pro Glu Ala Ala Lys Glu Ala Glu Leu Ala Ala Arg
            20                  25                  30          
Ile Leu Leu Asp Gln Gly Gln Thr His Ser Val Glu Thr Pro Tyr Gly
        35                  40                  45              
Ser Val Thr Phe Thr Val Tyr Gly Thr Pro Lys Pro Lys Arg Pro Ala
    50                  55                  60                  
Ile Leu Thr Tyr His Asp Val Gly Leu Asn Tyr Lys Ser Cys Phe Gln
65                  70                  75                  80  
Pro Leu Phe Gln Phe Glu Asp Met Gln Glu Ile Ile Gln Asn Phe Val
                85                  90                  95      
Arg Val His Val Asp Ala Pro Gly Met Glu Glu Gly Ala Pro Val Phe
            100                 105                 110         
Pro Leu Gly Tyr Gln Tyr Pro Ser Leu Asp Gln Leu Ala Asp Met Ile
        115                 120                 125             
Pro Cys Val Leu Gln Tyr Leu Asn Phe Ser Thr Ile Ile Gly Val Gly
    130                 135                 140                 
Val Gly Ala Gly Ala Tyr Ile Leu Ala Arg Tyr Ala Leu Asn His Pro
145                 150                 155                 160 
Asp Thr Val Glu Gly Leu Val Leu Ile Asn Ile Asp Pro Asn Ala Lys
                165                 170                 175     
Gly Trp Met Asp Trp Ala Ala His Lys Leu Thr Gly Leu Thr Ser Ser
            180                 185                 190         
Ile Pro Glu Met Ile Leu Gly His Leu Phe Ser Gln Glu Glu Leu Ser
        195                 200                 205             
Gly Asn Ser Glu Leu Ile Gln Lys Tyr Arg Asn Ile Ile Thr His Ala
    210                 215                 220                 
Pro Asn Leu Asp Asn Ile Glu Leu Tyr Trp Asn Ser Tyr Asn Asn Arg
225                 230                 235                 240 
Arg Asp Leu Asn Phe Glu Arg Gly Gly Asp Ile Thr Leu Arg Cys Pro
                245                 250                 255     
Val Met Leu Val Val Gly Asp Gln Ala Pro His Glu Asp Ala Val Val
            260                 265                 270         
Glu Cys Asn Ser Lys Leu Asp Pro Thr Gln Thr Ser Phe Leu Lys Met
        275                 280                 285             
Ala Asp Ser Gly Gly Gln Pro Gln Leu Thr Gln Pro Gly Lys Leu Thr
    290                 295                 300                 
Glu Ala Phe Lys Tyr Phe Leu Gln Gly Met Gly Tyr Met Ala Ser Ser
305                 310                 315                 320 
Cys Met Thr Arg Leu Ser Arg Ser Arg Thr Ala Ser Leu Thr Ser Ala
                325                 330                 335     
Ala Ser Val Asp Gly Asn Arg Ser Arg Ser Arg Thr Leu Ser Gln Ser
            340                 345                 350         
Ser Glu Ser Gly Thr Leu Ser Ser Gly Pro Pro Gly His Thr Met Glu
        355                 360                 365             
Val Ser Cys
    370     


<210> 6816
<211> 968
<212> PRT
<213> Homo sapiens

<400> 6816
Met Val Asn Ser Ser Arg Val Gln Pro Gln Gln Pro Gly Asp Ala Lys
 1               5                  10                  15      
Arg Pro Pro Ala Pro Arg Ala Pro Asp Pro Gly Arg Leu Met Ala Gly
            20                  25                  30          
Cys Ala Ala Val Gly Ala Ser Leu Ala Ala Pro Gly Arg Leu Cys Glu
        35                  40                  45              
Gln Arg Gly Leu Glu Ile Glu Met Gln Arg Ile Arg Gln Ala Ala Ala
    50                  55                  60                  
Arg Asp Pro Pro Ala Gly Ala Ala Ala Ser Pro Ser Pro Pro Leu Ser
65                  70                  75                  80  
Ser Cys Ser Arg Gln Ala Trp Ser Arg Asp Asn Pro Gly Phe Glu Ala
                85                  90                  95      
Glu Glu Glu Glu Glu Glu Val Glu Gly Glu Glu Gly Gly Met Val Val
            100                 105                 110         
Glu Met Asp Val Glu Trp Arg Pro Gly Ser Arg Arg Ser Ala Ala Ser
        115                 120                 125             
Ser Ala Val Ser Ser Val Gly Ala Arg Ser Arg Gly Leu Gly Gly Tyr
    130                 135                 140                 
His Gly Ala Gly His Pro Ser Gly Arg Arg Arg Arg Arg Glu Asp Gln
145                 150                 155                 160 
Gly Pro Pro Cys Pro Ser Pro Val Gly Gly Gly Asp Pro Leu His Arg
                165                 170                 175     
His Leu Pro Leu Glu Gly Gln Pro Pro Arg Val Ala Trp Ala Glu Arg
            180                 185                 190         
Leu Val Arg Gly Leu Arg Gly Leu Trp Gly Thr Arg Leu Met Glu Glu
        195                 200                 205             
Ser Ser Thr Asn Arg Glu Lys Tyr Leu Lys Ser Val Leu Arg Glu Leu
    210                 215                 220                 
Val Thr Tyr Leu Leu Phe Leu Ile Val Leu Cys Ile Leu Thr Tyr Gly
225                 230                 235                 240 
Met Met Ser Ser Asn Val Tyr Tyr Tyr Thr Arg Met Met Ser Gln Leu
                245                 250                 255     
Phe Leu Asp Thr Pro Val Ser Lys Thr Glu Lys Thr Asn Phe Lys Thr
            260                 265                 270         
Leu Ser Ser Met Glu Asp Phe Trp Lys Phe Thr Glu Gly Ser Leu Leu
        275                 280                 285             
Asp Gly Leu Tyr Trp Lys Met Gln Pro Ser Asn Gln Thr Glu Ala Asp
    290                 295                 300                 
Asn Arg Ser Phe Ile Phe Tyr Glu Asn Leu Leu Leu Gly Val Pro Arg
305                 310                 315                 320 
Ile Arg Gln Leu Arg Val Arg Asn Gly Ser Cys Ser Ile Pro Gln Asp
                325                 330                 335     
Leu Arg Asp Glu Ile Lys Glu Cys Tyr Asp Val Tyr Ser Val Ser Ser
            340                 345                 350         
Glu Asp Arg Ala Pro Phe Gly Pro Arg Asn Gly Thr Ala Trp Ile Tyr
        355                 360                 365             
Thr Ser Glu Lys Asp Leu Asn Gly Ser Ser His Trp Gly Ile Ile Ala
    370                 375                 380                 
Thr Tyr Ser Gly Ala Gly Tyr Tyr Leu Asp Leu Ser Arg Thr Arg Glu
385                 390                 395                 400 
Glu Thr Ala Ala Gln Val Ala Ser Leu Lys Lys Asn Val Trp Leu Asp
                405                 410                 415     
Arg Gly Thr Arg Ala Thr Phe Ile Asp Phe Ser Val Tyr Asn Ala Asn
            420                 425                 430         
Ile Asn Leu Phe Cys Val Val Arg Leu Leu Val Glu Phe Pro Ala Thr
        435                 440                 445             
Gly Gly Val Ile Pro Ser Trp Gln Phe Gln Pro Leu Lys Leu Ile Arg
    450                 455                 460                 
Tyr Val Thr Thr Phe Asp Phe Phe Leu Ala Ala Cys Glu Ile Ile Phe
465                 470                 475                 480 
Cys Phe Phe Ile Phe Tyr Tyr Val Val Glu Glu Ile Leu Glu Ile Arg
                485                 490                 495     
Ile His Lys Leu His Tyr Phe Arg Ser Phe Trp Asn Cys Leu Asp Val
            500                 505                 510         
Val Ile Val Val Leu Ser Val Val Ala Ile Gly Ile Asn Ile Tyr Arg
        515                 520                 525             
Thr Ser Asn Val Glu Val Leu Leu Gln Phe Leu Glu Asp Gln Asn Thr
    530                 535                 540                 
Phe Pro Asn Phe Glu His Leu Ala Tyr Trp Gln Ile Gln Phe Asn Asn
545                 550                 555                 560 
Ile Ala Ala Val Thr Val Phe Phe Val Trp Ile Lys Leu Phe Lys Phe
                565                 570                 575     
Ile Asn Phe Asn Arg Thr Met Ser Gln Leu Ser Thr Thr Met Ser Arg
            580                 585                 590         
Cys Ala Lys Asp Leu Phe Gly Phe Ala Ile Met Phe Phe Ile Ile Phe
        595                 600                 605             
Leu Ala Tyr Ala Gln Leu Ala Tyr Leu Val Phe Gly Thr Gln Val Asp
    610                 615                 620                 
Asp Phe Ser Thr Phe Gln Glu Cys Ile Phe Thr Gln Phe Arg Ile Ile
625                 630                 635                 640 
Leu Gly Asp Ile Asn Phe Ala Glu Ile Glu Glu Ala Asn Arg Val Leu
                645                 650                 655     
Gly Pro Ile Tyr Phe Thr Thr Phe Val Phe Phe Met Phe Phe Ile Leu
            660                 665                 670         
Leu Asn Met Phe Leu Ala Ile Ile Asn Asp Thr Tyr Ser Glu Val Lys
        675                 680                 685             
Ser Asp Leu Ala Gln Gln Lys Ala Glu Met Glu Leu Ser Asp Leu Ile
    690                 695                 700                 
Arg Lys Gly Tyr His Lys Ala Leu Val Lys Leu Lys Leu Lys Lys Asn
705                 710                 715                 720 
Thr Val Asp Asp Ile Ser Glu Ser Leu Arg Gln Gly Gly Gly Lys Leu
                725                 730                 735     
Asn Phe Asp Glu Leu Arg Gln Asp Leu Lys Gly Lys Gly His Thr Asp
            740                 745                 750         
Ala Glu Ile Glu Ala Ile Phe Thr Lys Tyr Asp Gln Asp Gly Asp Gln
        755                 760                 765             
Glu Leu Thr Glu His Glu His Gln Gln Met Arg Asp Asp Leu Glu Lys
    770                 775                 780                 
Glu Arg Glu Asp Leu Asp Leu Asp His Ser Ser Leu Pro Arg Pro Met
785                 790                 795                 800 
Ser Ser Arg Ser Phe Pro Arg Ser Leu Asp Asp Ser Glu Glu Asp Asp
                805                 810                 815     
Asp Glu Asp Ser Gly His Ser Ser Arg Arg Arg Gly Ser Ile Ser Ser
            820                 825                 830         
Gly Val Ser Tyr Glu Glu Phe Gln Val Leu Val Arg Arg Val Asp Arg
        835                 840                 845             
Met Glu His Ser Ile Gly Ser Ile Val Ser Lys Ile Asp Ala Val Ile
    850                 855                 860                 
Val Lys Leu Glu Ile Met Glu Arg Ala Lys Leu Lys Arg Arg Glu Val
865                 870                 875                 880 
Leu Gly Arg Leu Leu Asp Gly Val Ala Glu Asp Glu Arg Leu Gly Arg
                885                 890                 895     
Asp Ser Glu Ile His Arg Glu Gln Met Glu Arg Leu Val Arg Glu Glu
            900                 905                 910         
Leu Glu Arg Trp Glu Ser Asp Asp Ala Ala Ser Gln Ile Ser His Gly
        915                 920                 925             
Leu Gly Thr Pro Val Gly Leu Asn Gly Gln Pro Arg Pro Arg Ser Ser
    930                 935                 940                 
Arg Pro Ser Ser Ser Gln Ser Thr Glu Gly Met Glu Gly Ala Gly Gly
945                 950                 955                 960 
Asn Gly Ser Ser Asn Val His Val
                965             


<210> 6817
<211> 321
<212> PRT
<213> Homo sapiens

<400> 6817
Met Ala Thr Gly Gly Gln Gln Lys Glu Asn Thr Leu Leu His Leu Phe
 1               5                  10                  15      
Ala Gly Gly Cys Gly Gly Thr Val Gly Ala Ile Phe Thr Cys Pro Leu
            20                  25                  30          
Glu Val Ile Lys Thr Arg Leu Gln Ser Leu Arg Leu Ala Leu Arg Thr
        35                  40                  45              
Val Tyr Tyr Pro Gln Val His Leu Gly Thr Ile Ser Gly Ala Gly Met
    50                  55                  60                  
Val Arg Pro Thr Ser Val Thr Pro Gly Leu Phe Gln Val Leu Lys Ser
65                  70                  75                  80  
Ile Leu Glu Lys Glu Gly Pro Lys Ser Leu Phe Arg Gly Leu Gly Pro
                85                  90                  95      
Asn Leu Val Gly Val Ala Pro Ser Arg Ala Val Tyr Phe Ala Cys Tyr
            100                 105                 110         
Ser Lys Ala Lys Glu Gln Phe Asn Gly Ile Phe Val Pro Asn Ser Asn
        115                 120                 125             
Ile Val His Ile Phe Ser Ala Gly Ser Ala Ala Phe Ile Thr Asn Ser
    130                 135                 140                 
Leu Met Asn Pro Ile Trp Met Val Lys Thr Arg Met Gln Leu Glu Gln
145                 150                 155                 160 
Lys Val Arg Gly Phe Lys Gln Val Asn Thr Leu Gln Cys Ala Arg Tyr
                165                 170                 175     
Val Tyr Gln Thr Glu Gly Ile Arg Gly Phe Tyr Arg Gly Leu Thr Ala
            180                 185                 190         
Ser Tyr Ala Gly Ile Ser Glu Thr Ile Ile Cys Phe Ala Ile Tyr Glu
        195                 200                 205             
Ser Leu Lys Lys Tyr Leu Lys Glu Ala Pro Leu Ala Ser Ser Ala Asn
    210                 215                 220                 
Gly Thr Glu Lys Asn Ser Thr Ser Phe Phe Gly Leu Met Ala Ala Ala
225                 230                 235                 240 
Ala Leu Ser Lys Gly Cys Ala Ser Cys Ile Ala Tyr Pro His Glu Val
                245                 250                 255     
Ile Arg Thr Arg Leu Arg Glu Glu Gly Thr Lys Tyr Lys Ser Phe Val
            260                 265                 270         
Gln Thr Ala Arg Leu Val Phe Gln Glu Glu Gly Tyr Leu Ala Phe Tyr
        275                 280                 285             
Arg Gly Leu Phe Ala Gln Leu Ile Arg Arg Ile Pro Asn Thr Ala Ile
    290                 295                 300                 
Val Leu Ser Thr Tyr Glu Leu Ile Val Tyr Leu Leu Glu Asp Arg Thr
305                 310                 315                 320 
Gln
    


<210> 6818
<211> 321
<212> PRT
<213> Homo sapiens

<400> 6818
Met Ala Thr Gly Gly Gln Gln Lys Glu Asn Thr Leu Leu His Leu Phe
 1               5                  10                  15      
Ala Gly Gly Cys Gly Gly Thr Val Gly Ala Ile Phe Thr Cys Pro Leu
            20                  25                  30          
Glu Val Ile Lys Thr Arg Leu Gln Ser Ser Arg Leu Ala Leu Arg Thr
        35                  40                  45              
Val Tyr Tyr Pro Gln Val His Leu Gly Thr Ile Ser Gly Ala Gly Met
    50                  55                  60                  
Val Arg Pro Thr Ser Val Thr Pro Gly Leu Phe Gln Val Leu Lys Ser
65                  70                  75                  80  
Ile Leu Glu Lys Glu Gly Pro Lys Ser Leu Phe Arg Gly Leu Gly Pro
                85                  90                  95      
Asn Leu Val Gly Val Ala Pro Ser Arg Ala Val Tyr Phe Ala Cys Tyr
            100                 105                 110         
Ser Lys Ala Lys Glu Gln Phe Asn Gly Ile Phe Val Pro Asn Ser Asn
        115                 120                 125             
Ile Val His Ile Phe Ser Ala Gly Ser Ala Ala Phe Ile Thr Asn Ser
    130                 135                 140                 
Leu Met Asn Pro Ile Trp Met Val Lys Thr Arg Met Gln Leu Glu Gln
145                 150                 155                 160 
Lys Val Arg Gly Ser Lys Gln Met Asn Thr Leu Gln Cys Ala Arg Tyr
                165                 170                 175     
Val Tyr Gln Thr Glu Gly Ile Arg Gly Phe Tyr Arg Gly Leu Thr Ala
            180                 185                 190         
Ser Tyr Ala Gly Ile Ser Glu Thr Ile Ile Cys Phe Ala Ile Tyr Glu
        195                 200                 205             
Ser Leu Lys Lys Tyr Leu Lys Glu Ala Pro Leu Ala Ser Ser Ala Asn
    210                 215                 220                 
Gly Thr Glu Lys Asn Ser Thr Ser Phe Phe Gly Leu Met Ala Ala Ala
225                 230                 235                 240 
Ala Leu Ser Lys Gly Cys Ala Ser Cys Ile Ala Tyr Pro His Glu Val
                245                 250                 255     
Ile Arg Thr Arg Leu Arg Glu Glu Gly Thr Lys Tyr Lys Ser Phe Val
            260                 265                 270         
Gln Thr Ala Arg Leu Val Phe Arg Glu Glu Gly Tyr Leu Ala Phe Tyr
        275                 280                 285             
Arg Gly Leu Phe Ala Gln Leu Ile Arg Gln Ile Pro Asn Thr Ala Ile
    290                 295                 300                 
Val Leu Ser Thr Tyr Glu Leu Ile Val Tyr Leu Leu Glu Asp Arg Thr
305                 310                 315                 320 
Gln
    


<210> 6819
<211> 1617
<212> PRT
<213> Homo sapiens

<400> 6819
Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr Lys Ala Leu Leu
 1               5                  10                  15      
Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Leu
            20                  25                  30          
Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile Ala Leu Phe Ser
        35                  40                  45              
Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala Pro Gln Asn Leu
    50                  55                  60                  
Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met Val Val Tyr Thr
65                  70                  75                  80  
Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys Thr Ala Leu Ala
                85                  90                  95      
Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro Asn Lys Thr His
            100                 105                 110         
Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala Met Gly Ile Ile
        115                 120                 125             
Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe Gln Gly Tyr Asn
    130                 135                 140                 
Ser Pro Leu Trp Lys Glu Asp Phe Ser Ala His Cys Trp Asp Gly Tyr
145                 150                 155                 160 
Gly Glu Phe Ser Cys Thr Leu Thr Lys Tyr Trp Asn Arg Gly Phe Val
                165                 170                 175     
Ala Leu Gln Thr Ala Ile Asn Thr Ala Ile Ile Glu Ile Thr Thr Asn
            180                 185                 190         
His Pro Val Met Glu Glu Leu Met Ser Val Thr Ala Ile Thr Met Lys
        195                 200                 205             
Thr Leu Pro Phe Ile Thr Lys Asn Leu Leu His Asn Glu Met Phe Ile
    210                 215                 220                 
Leu Phe Phe Leu Leu His Phe Ser Pro Leu Val Tyr Phe Ile Ser Leu
225                 230                 235                 240 
Asn Val Thr Lys Glu Arg Lys Lys Ser Lys Asn Leu Met Lys Met Met
                245                 250                 255     
Gly Leu Gln Asp Ser Ala Phe Trp Leu Ser Trp Gly Leu Ile Tyr Ala
            260                 265                 270         
Gly Phe Ile Phe Ile Ile Ser Ile Phe Val Thr Ile Ile Ile Thr Phe
        275                 280                 285             
Thr Gln Ile Ile Val Met Thr Gly Phe Met Val Ile Phe Ile Leu Phe
    290                 295                 300                 
Phe Leu Tyr Gly Leu Ser Leu Val Ala Leu Val Phe Leu Met Ser Val
305                 310                 315                 320 
Leu Leu Lys Lys Ala Val Leu Thr Asn Leu Val Val Phe Leu Leu Thr
                325                 330                 335     
Leu Phe Trp Gly Cys Leu Gly Phe Thr Val Phe Tyr Glu Gln Leu Pro
            340                 345                 350         
Ser Ser Leu Glu Trp Ile Leu Asn Ile Cys Ser Pro Phe Ala Phe Thr
        355                 360                 365             
Thr Gly Met Ile Gln Ile Ile Lys Leu Asp Tyr Asn Leu Asn Gly Val
    370                 375                 380                 
Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Thr Met Ile Ala Thr Phe
385                 390                 395                 400 
Ser Met Leu Leu Leu Asp Gly Leu Ile Tyr Leu Leu Leu Ala Leu Tyr
                405                 410                 415     
Phe Asp Lys Ile Leu Pro Tyr Gly Asp Glu Arg His Tyr Ser Pro Leu
            420                 425                 430         
Phe Phe Leu Asn Ser Ser Ser Cys Phe Gln His Gln Arg Thr Asn Ala
        435                 440                 445             
Lys Val Ile Glu Lys Glu Ile Asp Ala Glu His Pro Ser Asp Asp Tyr
    450                 455                 460                 
Phe Glu Pro Val Ala Pro Glu Phe Gln Gly Lys Glu Ala Ile Arg Ile
465                 470                 475                 480 
Arg Asn Val Lys Lys Glu Tyr Lys Gly Lys Ser Gly Lys Val Glu Ala
                485                 490                 495     
Leu Lys Gly Leu Leu Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Ile
            500                 505                 510         
Leu Gly His Ser Gly Ala Gly Lys Ser Ser Leu Leu Asn Ile Leu Asn
        515                 520                 525             
Gly Leu Ser Val Pro Thr Glu Gly Ser Val Thr Ile Tyr Asn Lys Asn
    530                 535                 540                 
Leu Ser Glu Met Gln Asp Leu Glu Glu Ile Arg Lys Ile Thr Gly Val
545                 550                 555                 560 
Cys Pro Gln Phe Asn Val Gln Phe Asp Ile Leu Thr Val Lys Glu Asn
                565                 570                 575     
Leu Ser Leu Phe Ala Lys Ile Lys Gly Ile His Leu Lys Glu Val Glu
            580                 585                 590         
Gln Glu Val Gln Arg Ile Leu Leu Glu Leu Asp Met Gln Asn Ile Gln
        595                 600                 605             
Asp Asn Leu Ala Lys His Leu Ser Glu Gly Gln Lys Arg Lys Leu Thr
    610                 615                 620                 
Phe Gly Ile Thr Ile Leu Gly Asp Pro Gln Ile Leu Leu Leu Asp Glu
625                 630                 635                 640 
Pro Thr Thr Gly Leu Asp Pro Phe Ser Arg Asp Gln Val Trp Ser Leu
                645                 650                 655     
Leu Arg Glu Arg Arg Ala Asp His Val Ile Leu Phe Ser Thr Gln Ser
            660                 665                 670         
Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Ile Met Ser Asn
        675                 680                 685             
Gly Arg Leu Lys Cys Ala Gly Ser Ser Met Phe Leu Lys Arg Arg Trp
    690                 695                 700                 
Gly Leu Gly Tyr His Leu Ser Leu His Arg Asn Glu Ile Cys Asn Pro
705                 710                 715                 720 
Glu Gln Ile Thr Ser Phe Ile Thr His His Ile Pro Asp Ala Lys Leu
                725                 730                 735     
Lys Thr Glu Asn Lys Glu Lys Leu Val Tyr Thr Leu Pro Leu Glu Arg
            740                 745                 750         
Thr Asn Thr Phe Pro Asp Leu Phe Ser Asp Leu Asp Lys Cys Ser Asp
        755                 760                 765             
Gln Gly Val Thr Gly Tyr Asp Ile Ser Met Ser Thr Leu Asn Glu Val
    770                 775                 780                 
Phe Met Lys Leu Glu Gly Gln Ser Thr Ile Glu Gln Asp Phe Glu Gln
785                 790                 795                 800 
Val Glu Met Ile Arg Asp Ser Glu Ser Leu Asn Glu Met Glu Leu Ala
                805                 810                 815     
His Ser Ser Phe Ser Glu Met Gln Thr Ala Val Ser Asp Met Gly Leu
            820                 825                 830         
Trp Arg Met Gln Val Phe Ala Met Ala Arg Leu Arg Phe Leu Lys Leu
        835                 840                 845             
Lys Arg Gln Thr Lys Val Leu Leu Thr Leu Leu Leu Val Phe Gly Ile
    850                 855                 860                 
Ala Ile Phe Pro Leu Ile Val Glu Asn Ile Met Tyr Ala Met Leu Asn
865                 870                 875                 880 
Glu Lys Ile Asp Trp Glu Phe Lys Asn Glu Leu Tyr Phe Leu Ser Pro
                885                 890                 895     
Gly Gln Leu Pro Gln Glu Pro Arg Thr Ser Leu Leu Ile Ile Asn Asn
            900                 905                 910         
Thr Glu Ser Asn Ile Glu Asp Phe Ile Lys Ser Leu Lys His Gln Asn
        915                 920                 925             
Ile Leu Leu Glu Val Asp Asp Phe Glu Asn Arg Asn Gly Thr Asp Gly
    930                 935                 940                 
Leu Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Lys Gln Lys Asp Tyr
945                 950                 955                 960 
Arg Phe Ser Val Val Cys Asn Thr Lys Arg Leu His Cys Phe Pro Ile
                965                 970                 975     
Leu Met Asn Ile Ile Ser Asn Gly Leu Leu Gln Met Phe Asn His Thr
            980                 985                 990         
Gln His Ile Arg Ile Ser Gln Ala Pro Phe Pro Leu Ser His Ile Gly
        995                 1000                1005            
Leu Trp Thr Gly Leu Pro Asp Gly Ser Phe Phe Leu Phe Leu Val Leu
    1010                1015                1020                
Cys Ser Ile Ser Pro Tyr Ile Thr Met Gly Ser Ile Ser Asp Tyr Lys
1025                1030                1035                1040
Lys Asn Ala Lys Ser Gln Leu Trp Ile Ser Gly Leu Tyr Thr Ser Ala
                1045                1050                1055    
Tyr Trp Cys Gly Gln Ala Leu Val Asp Val Ser Phe Phe Ile Leu Ile
            1060                1065                1070        
Leu Leu Leu Met Tyr Leu Ile Phe Tyr Ile Glu Asn Met Gln Tyr Leu
        1075                1080                1085            
Leu Ile Thr Ser Gln Ile Val Phe Ala Leu Val Ile Val Thr Pro Gly
    1090                1095                1100                
Tyr Ala Ala Ser Leu Val Phe Phe Ile Tyr Met Ile Ser Phe Ile Phe
1105                1110                1115                1120
Arg Lys Arg Arg Lys Asn Ser Gly Leu Trp Ser Phe Tyr Phe Phe Phe
                1125                1130                1135    
Ala Ser Thr Ile Met Phe Ser Ile Thr Leu Ile Asn His Phe Asp Leu
            1140                1145                1150        
Ser Ile Leu Ile Thr Thr Met Val Leu Val Pro Ser Tyr Thr Leu Leu
        1155                1160                1165            
Gly Phe Lys Thr Phe Leu Glu Val Arg Asp Gln Glu His Tyr Arg Glu
    1170                1175                1180                
Phe Pro Glu Ala Asn Phe Glu Leu Ser Ala Thr Asp Phe Leu Val Cys
1185                1190                1195                1200
Phe Ile Pro Tyr Phe Gln Thr Leu Leu Phe Val Phe Val Leu Arg Cys
                1205                1210                1215    
Met Glu Leu Lys Cys Gly Lys Lys Arg Met Arg Lys Asp Pro Val Phe
            1220                1225                1230        
Arg Ile Ser Pro Gln Ser Arg Asp Ala Lys Pro Asn Pro Glu Glu Pro
        1235                1240                1245            
Ile Asp Glu Asp Glu Asp Ile Gln Thr Glu Arg Ile Arg Thr Ala Thr
    1250                1255                1260                
Ala Leu Thr Thr Ser Ile Leu Asp Glu Lys Pro Val Ile Ile Ala Ser
1265                1270                1275                1280
Cys Leu His Lys Glu Tyr Ala Gly Gln Lys Lys Ser Cys Phe Ser Lys
                1285                1290                1295    
Arg Lys Lys Lys Ile Ala Ala Arg Asn Ile Ser Phe Cys Val Gln Glu
            1300                1305                1310        
Gly Glu Ile Leu Gly Leu Leu Gly Pro Asn Gly Ala Gly Lys Ser Ser
        1315                1320                1325            
Ser Ile Arg Met Ile Ser Gly Ile Thr Lys Pro Thr Ala Gly Glu Val
    1330                1335                1340                
Glu Leu Lys Gly Cys Ser Ser Val Leu Gly His Leu Gly Tyr Cys Pro
1345                1350                1355                1360
Gln Glu Asn Val Leu Trp Pro Met Leu Thr Leu Arg Glu His Leu Glu
                1365                1370                1375    
Val Tyr Ala Ala Val Lys Gly Leu Arg Lys Ala Asp Ala Arg Leu Ala
            1380                1385                1390        
Ile Ala Arg Leu Val Ser Ala Phe Lys Leu His Glu Gln Leu Asn Val
        1395                1400                1405            
Pro Val Gln Lys Leu Thr Ala Gly Ile Thr Arg Lys Leu Cys Phe Val
    1410                1415                1420                
Leu Ser Leu Leu Gly Asn Ser Pro Val Leu Leu Leu Asp Glu Pro Ser
1425                1430                1435                1440
Thr Gly Ile Asp Pro Thr Gly Gln Gln Gln Met Trp Gln Ala Ile Gln
                1445                1450                1455    
Ala Val Val Lys Asn Thr Glu Arg Gly Val Leu Leu Thr Thr His Asn
            1460                1465                1470        
Leu Ala Glu Ala Glu Ala Leu Cys Asp Arg Val Ala Ile Met Val Ser
        1475                1480                1485            
Gly Arg Leu Arg Cys Ile Gly Ser Ile Gln His Leu Lys Asn Lys Leu
    1490                1495                1500                
Gly Lys Asp Tyr Ile Leu Glu Leu Lys Val Lys Glu Thr Ser Gln Val
1505                1510                1515                1520
Thr Leu Val His Thr Glu Ile Leu Lys Leu Phe Pro Gln Ala Ala Gly
                1525                1530                1535    
Gln Glu Arg Tyr Ser Ser Leu Leu Thr Tyr Lys Leu Pro Val Ala Asp
            1540                1545                1550        
Val Tyr Pro Leu Ser Gln Thr Phe His Lys Leu Glu Ala Val Lys His
        1555                1560                1565            
Asn Phe Asn Leu Glu Glu Tyr Ser Leu Ser Gln Cys Thr Leu Glu Lys
    1570                1575                1580                
Val Phe Leu Glu Leu Ser Lys Glu Gln Glu Val Gly Asn Phe Asp Glu
1585                1590                1595                1600
Glu Ile Asp Thr Thr Met Arg Trp Lys Leu Leu Pro His Ser Asp Glu
                1605                1610                1615    
Pro
    


<210> 6820
<211> 392
<212> PRT
<213> Homo sapiens

<400> 6820
Met Leu Lys Val Leu Asn Tyr Ile Phe Lys Gly Pro Phe Ser Met Tyr
 1               5                  10                  15      
Ser Asn Ile Phe Asn Gly Ser Gly Asp Met Asp Leu Glu Pro Leu Phe
            20                  25                  30          
Tyr Leu Gln Gln Leu Val Leu Asp Phe Ile Ile Phe Tyr His Ser Cys
        35                  40                  45              
Asn Arg Glu Arg Thr Ile Ser Leu Gly Val Ala Ser His Asn Val Cys
    50                  55                  60                  
Val Gly Ile Cys Val Gly Val Tyr Leu His Ser Leu Asn Asn Cys Met
65                  70                  75                  80  
Ile Arg Lys Phe Leu Ser Leu Phe Gln Met Phe His Val Val Ile Ile
                85                  90                  95      
Val Leu Gln Asn Pro Lys Gly Tyr Val Leu Leu Met Lys Met Ser Ser
            100                 105                 110         
Leu Gly Gly Gly Glu Gln Val Ile Met Cys Arg Phe Phe Leu Ala Glu
        115                 120                 125             
Val Cys Phe Leu Trp Glu Gln Pro Ser Arg Ile Asn Leu Phe Cys Phe
    130                 135                 140                 
Leu Phe Trp Glu Leu Arg Pro Ile Leu Arg Cys Pro Lys Ser Pro Ser
145                 150                 155                 160 
Ile Leu Phe Asp Leu Leu Ile His Ile Asp Leu Ile Ala Lys Tyr Asp
                165                 170                 175     
His Ile Asp Val Val Lys Leu Asn Thr Phe Val Gln Ile Glu Ser Leu
            180                 185                 190         
His Leu Leu Ser Val Lys Gln Trp Lys Thr Val Met Glu Lys Gln Thr
        195                 200                 205             
Cys Phe Asp Arg Phe Ile Cys Val Lys Lys Val Ser Ile Leu Trp Asn
    210                 215                 220                 
Ala Ala Asp Gln Ile Met Ser Cys Arg Leu Cys Ser Lys Gln His Ser
225                 230                 235                 240 
Ser Thr Thr Val Leu Leu Ser Ile Pro Ser Leu Ala Val Thr Glu Met
                245                 250                 255     
Lys Asn Ile Ser Ile Asp Leu Cys Phe Ala Leu Val Gln Glu Thr Ile
            260                 265                 270         
Cys Arg Glu Pro Asn Ile Ala Thr Glu Asp Leu Ile Ser Cys Gln Lys
        275                 280                 285             
Ile Gln Asn Leu Phe Pro Phe Lys His Asp Thr Leu Ser Phe Leu Val
    290                 295                 300                 
Asp Leu Ala Lys Arg Lys Asn Ile Ala Leu Asn Ser Pro Ile Pro Ser
305                 310                 315                 320 
Val Glu Ser Leu Arg Ile Phe Ser Asn Glu Leu Cys Met Val Leu Trp
                325                 330                 335     
Tyr Phe Met Phe Pro Lys Glu Asn Gly Tyr Met Lys Asn Leu Ser Ser
            340                 345                 350         
Val Ile Ile Phe Leu Thr Lys Ile Leu Leu Val Met Val Val Leu Ile
        355                 360                 365             
Asn Leu Ile Val Ile Met Ile Thr Gln Cys Leu Pro Ile Ser Asn His
    370                 375                 380                 
His Ile Val Tyr Leu Lys Tyr Ile
385                 390         


<210> 6821
<211> 93
<212> PRT
<213> Homo sapiens

<400> 6821
Arg Pro Thr Thr Leu Phe Glu Thr Met Gly Lys Ala Asp Ile Trp Leu
 1               5                  10                  15      
Met Arg Asn Ser Trp Asn Phe Gln Phe Pro His Pro Phe Leu Pro Asn
            20                  25                  30          
Val Asp Phe Val Gly Gly Phe His Cys Lys Pro Ala Lys Pro Leu Pro
        35                  40                  45              
Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly Val Val
    50                  55                  60                  
Val Phe Ser Leu Gly Ser Met Val Ser Asn Met Thr Ala Glu Arg Ala
65                  70                  75                  80  
Asn Val Ile Ala Thr Ala Leu Ala Lys Ile Pro Gln Lys
                85                  90              


<210> 6822
<211> 482
<212> PRT
<213> Homo sapiens

<400> 6822
Gly Lys Val Leu Val Trp Thr Gly Glu Tyr Ser His Trp Met Asn Met
 1               5                  10                  15      
Lys Thr Ile Leu Lys Glu Leu Val Gln Arg Gly His Glu Val Thr Val
            20                  25                  30          
Leu Ala Ser Ser Ala Ser Ile Leu Phe Asp Pro Asn Asp Ala Phe Thr
        35                  40                  45              
Leu Lys Leu Glu Val Tyr Pro Thr Ser Leu Thr Lys Thr Glu Phe Glu
    50                  55                  60                  
Asn Ile Ile Met Gln Gln Val Lys Arg Trp Ser Asp Ile Gln Lys Asp
65                  70                  75                  80  
Ser Phe Trp Leu Tyr Phe Ser Gln Glu Gln Glu Ile Leu Trp Glu Phe
                85                  90                  95      
His Asp Ile Phe Arg Asn Phe Cys Lys Asp Val Val Ser Asn Lys Lys
            100                 105                 110         
Val Met Lys Lys Leu Gln Glu Ser Arg Phe Asp Ile Ile Phe Ala Asp
        115                 120                 125             
Ala Phe Phe Pro Cys Gly Glu Leu Leu Ala Ala Leu Leu Asn Ile Pro
    130                 135                 140                 
Phe Val Tyr Ser Leu Cys Phe Thr Pro Gly Tyr Thr Ile Glu Arg His
145                 150                 155                 160 
Ser Gly Gly Leu Ile Phe Pro Pro Ser Tyr Ile Pro Val Val Met Ser
                165                 170                 175     
Lys Leu Ser Asp Gln Met Thr Phe Met Glu Arg Val Lys Asn Met Ile
            180                 185                 190         
Tyr Val Leu Tyr Phe Asp Phe Trp Phe Gln Met Cys Asp Met Lys Lys
        195                 200                 205             
Trp Asp Gln Phe Tyr Ser Glu Val Leu Gly Arg Pro Thr Thr Leu Phe
    210                 215                 220                 
Glu Thr Met Gly Lys Ala Asp Ile Trp Leu Met Arg Asn Ser Trp Ser
225                 230                 235                 240 
Phe Gln Phe Pro His Pro Phe Leu Pro Asn Ile Asp Phe Val Gly Gly
                245                 250                 255     
Leu His Cys Lys Pro Ala Lys Pro Leu Pro Lys Glu Met Glu Glu Phe
            260                 265                 270         
Val Gln Ser Ser Gly Glu Asn Gly Val Val Val Phe Ser Leu Gly Ser
        275                 280                 285             
Met Val Ser Asn Met Thr Ala Glu Arg Ala Asn Val Ile Ala Thr Ala
    290                 295                 300                 
Leu Ala Lys Ile Pro Gln Ala Phe His Cys Ala Ser His Phe Ile Pro
305                 310                 315                 320 
Met Asn Asn Phe Ala Lys Ile His Pro Ile Leu Gly His Pro Lys Thr
                325                 330                 335     
Arg Ala Phe Ile Thr His Gly Gly Ala Ser Gly Ile Tyr Glu Ala Ile
            340                 345                 350         
Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe Trp Asp Gln Pro
        355                 360                 365             
Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Val Arg Leu Asp
    370                 375                 380                 
Phe His Thr Met Ser Ser Thr Asp Leu Leu Asn Ala Leu Lys Thr Val
385                 390                 395                 400 
Ile Asn Asp Pro Leu Tyr Lys Glu Asn Val Met Lys Leu Ser Arg Ile
                405                 410                 415     
Gln Arg Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp Ile
            420                 425                 430         
Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala Ala
        435                 440                 445             
Arg Asp Leu Thr Trp Phe Gln Tyr His Ser Leu Asp Val Ile Gly Phe
    450                 455                 460                 
Leu Leu Ala Cys Val Ala Thr Val Thr Phe Ile Ile Thr Lys Cys Cys
465                 470                 475                 480 
Leu Phe
        


<210> 6823
<211> 830
<212> PRT
<213> Homo sapiens

<400> 6823
Met Ala Asn Cys Gln Ile Ala Ile Leu Tyr Gln Arg Phe Gln Arg Val
 1               5                  10                  15      
Val Phe Gly Ile Ser Gln Leu Leu Cys Phe Ser Ala Leu Ile Ser Glu
            20                  25                  30          
Leu Thr Asn Gln Lys Glu Val Ala Ala Trp Thr Tyr His Tyr Ser Thr
        35                  40                  45              
Lys Ala Tyr Ser Trp Asn Ile Ser Arg Lys Tyr Cys Gln Asn Arg Tyr
    50                  55                  60                  
Thr Asp Leu Val Ala Ile Gln Asn Lys Asn Glu Ile Asp Tyr Leu Asn
65                  70                  75                  80  
Lys Val Leu Pro Tyr Tyr Ser Ser Tyr Tyr Trp Ile Gly Ile Arg Lys
                85                  90                  95      
Asn Asn Lys Thr Trp Thr Trp Val Gly Thr Lys Lys Ala Leu Thr Asn
            100                 105                 110         
Glu Ala Glu Asn Trp Ala Asp Asn Glu Pro Asn Asn Lys Arg Asn Asn
        115                 120                 125             
Glu Asp Cys Val Glu Ile Tyr Ile Lys Ser Pro Ser Ala Pro Gly Lys
    130                 135                 140                 
Trp Asn Asp Glu His Cys Leu Lys Lys Lys His Ala Leu Cys Tyr Thr
145                 150                 155                 160 
Ala Ser Cys Gln Asp Met Ser Cys Ser Lys Gln Gly Glu Cys Leu Glu
                165                 170                 175     
Thr Ile Gly Asn Tyr Thr Cys Ser Cys Tyr Pro Gly Phe Tyr Gly Pro
            180                 185                 190         
Glu Cys Glu Tyr Val Arg Glu Cys Gly Glu Leu Glu Leu Pro Gln His
        195                 200                 205             
Val Leu Met Asn Cys Ser His Pro Leu Gly Asn Phe Ser Phe Asn Ser
    210                 215                 220                 
Gln Cys Ser Phe His Cys Thr Asp Gly Tyr Gln Val Asn Gly Pro Ser
225                 230                 235                 240 
Lys Leu Glu Cys Leu Ala Ser Gly Ile Trp Thr Asn Lys Pro Pro Gln
                245                 250                 255     
Cys Leu Ala Ala Gln Cys Pro Pro Leu Lys Ile Pro Glu Arg Gly Asn
            260                 265                 270         
Met Ile Cys Leu His Ser Ala Lys Ala Phe Gln His Gln Ser Ser Cys
        275                 280                 285             
Ser Phe Ser Cys Glu Glu Gly Phe Ala Leu Val Gly Pro Glu Val Val
    290                 295                 300                 
Gln Cys Thr Ala Ser Gly Val Trp Thr Ala Pro Ala Pro Val Cys Lys
305                 310                 315                 320 
Ala Val Gln Cys Gln His Leu Glu Ala Pro Ser Glu Gly Thr Met Asp
                325                 330                 335     
Cys Val His Pro Leu Thr Ala Phe Ala Tyr Gly Ser Ser Cys Lys Phe
            340                 345                 350         
Glu Cys Gln Pro Gly Tyr Arg Val Arg Gly Leu Asp Met Leu Arg Cys
        355                 360                 365             
Ile Asp Ser Gly His Trp Ser Ala Pro Leu Pro Thr Cys Glu Ala Ile
    370                 375                 380                 
Ser Cys Glu Pro Leu Glu Ser Pro Val His Gly Ser Met Asp Cys Ser
385                 390                 395                 400 
Pro Ser Leu Arg Ala Phe Gln Tyr Asp Thr Asn Cys Ser Phe Arg Cys
                405                 410                 415     
Ala Glu Gly Phe Met Leu Arg Gly Ala Asp Ile Val Arg Cys Asp Asn
            420                 425                 430         
Leu Gly Gln Trp Thr Ala Pro Ala Pro Val Cys Gln Ala Leu Gln Cys
        435                 440                 445             
Gln Asp Leu Pro Val Pro Asn Glu Ala Arg Val Asn Cys Ser His Pro
    450                 455                 460                 
Phe Gly Ala Phe Arg Tyr Gln Ser Val Cys Ser Phe Thr Cys Asn Glu
465                 470                 475                 480 
Gly Leu Leu Leu Val Gly Ala Ser Val Leu Gln Cys Leu Ala Thr Gly
                485                 490                 495     
Asn Trp Asn Ser Val Pro Pro Glu Cys Gln Ala Ile Pro Cys Thr Pro
            500                 505                 510         
Leu Leu Ser Pro Gln Asn Gly Thr Met Thr Cys Val Gln Pro Leu Gly
        515                 520                 525             
Ser Ser Ser Tyr Lys Ser Thr Cys Gln Phe Ile Cys Asp Glu Gly Tyr
    530                 535                 540                 
Ser Leu Ser Gly Pro Glu Arg Leu Asp Cys Thr Arg Ser Gly Arg Trp
545                 550                 555                 560 
Thr Asp Ser Pro Pro Met Cys Glu Ala Ile Lys Cys Pro Glu Leu Phe
                565                 570                 575     
Ala Pro Glu Gln Gly Ser Leu Asp Cys Ser Asp Thr Arg Gly Glu Phe
            580                 585                 590         
Asn Val Gly Ser Thr Cys His Phe Ser Cys Asn Asn Gly Phe Lys Leu
        595                 600                 605             
Glu Gly Pro Asn Asn Val Glu Cys Thr Thr Ser Gly Arg Trp Ser Ala
    610                 615                 620                 
Thr Pro Pro Thr Cys Lys Gly Ile Ala Ser Leu Pro Thr Pro Gly Leu
625                 630                 635                 640 
Gln Cys Pro Ala Leu Thr Thr Pro Gly Gln Gly Thr Met Tyr Cys Arg
                645                 650                 655     
His His Pro Gly Thr Phe Gly Phe Asn Thr Thr Cys Tyr Phe Gly Cys
            660                 665                 670         
Asn Ala Gly Phe Thr Leu Ile Gly Asp Ser Thr Leu Ser Cys Arg Pro
        675                 680                 685             
Ser Gly Gln Trp Thr Ala Val Thr Pro Ala Cys Arg Ala Val Lys Cys
    690                 695                 700                 
Ser Glu Leu His Val Asn Lys Pro Ile Ala Met Asn Cys Ser Asn Leu
705                 710                 715                 720 
Trp Gly Asn Phe Ser Tyr Gly Ser Ile Cys Ser Phe His Cys Leu Glu
                725                 730                 735     
Gly Gln Leu Leu Asn Gly Ser Ala Gln Thr Ala Cys Gln Glu Asn Gly
            740                 745                 750         
His Trp Ser Thr Thr Val Pro Thr Cys Gln Ala Gly Pro Leu Thr Ile
        755                 760                 765             
Gln Glu Ala Leu Thr Tyr Phe Gly Gly Ala Val Ala Ser Thr Ile Gly
    770                 775                 780                 
Leu Ile Met Gly Gly Thr Leu Leu Ala Leu Leu Arg Lys Arg Phe Arg
785                 790                 795                 800 
Gln Lys Asp Asp Gly Lys Cys Pro Leu Asn Pro His Ser His Leu Gly
                805                 810                 815     
Thr Tyr Gly Val Phe Thr Asn Ala Ala Phe Asp Pro Ser Pro
            820                 825                 830 


<210> 6824
<211> 261
<212> PRT
<213> Homo sapiens

<400> 6824
Ile Tyr Tyr Ala Ile Ser Lys Ser Ile Gly Phe Gly Val Asp Thr Trp
 1               5                  10                  15      
Val Tyr Pro Asn Ile Thr Asp Pro Glu Tyr Gly Tyr Leu Ala Arg Glu
            20                  25                  30          
Tyr Ile Tyr Cys Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly
        35                  40                  45              
Glu Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Ile Phe
    50                  55                  60                  
Asp Phe Leu Ile Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val
65                  70                  75                  80  
Gly Ser Met Ile Ser Asn Met Asn Ala Thr Arg Ala Glu Phe Gln Ala
                85                  90                  95      
Lys Ile Asp Ala Val Lys His Tyr Met Gln Phe Arg Lys Val Ser Lys
            100                 105                 110         
Gly Met Glu Ala Lys Val Ile Arg Trp Phe Asp Tyr Leu Trp Thr Asn
        115                 120                 125             
Lys Lys Thr Val Asp Glu Arg Glu Ile Leu Lys Asn Leu Pro Ala Lys
    130                 135                 140                 
Leu Arg Ala Glu Ile Ala Ile Asn Val His Leu Ser Thr Leu Lys Lys
145                 150                 155                 160 
Val Arg Ile Phe His Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val
                165                 170                 175     
Leu Lys Leu Arg Pro Gln Val Phe Ser Pro Gly Asp Tyr Ile Cys Arg
            180                 185                 190         
Lys Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Lys Glu Gly Lys Leu
        195                 200                 205             
Ala Val Val Ala Asp Asp Gly Val Thr Gln Tyr Ala Leu Leu Ser Ala
    210                 215                 220                 
Gly Ser Cys Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys
225                 230                 235                 240 
Met Gly Asn Arg Arg Thr Ala Asn Ile Arg Ser Leu Gly Tyr Ser Asp
                245                 250                 255     
Leu Phe Cys Leu Ser
            260     


<210> 6825
<211> 309
<212> PRT
<213> Homo sapiens

<400> 6825
Met Glu Asn Arg Asn Asn Met Thr Glu Phe Val Leu Leu Gly Leu Thr
 1               5                  10                  15      
Glu Asn Pro Lys Met Gln Lys Ile Ile Phe Val Val Phe Phe Val Ile
            20                  25                  30          
Tyr Ile Ile Thr Val Val Gly Tyr Val Leu Ile Val Val Thr Ile Thr
        35                  40                  45              
Ala Ser Pro Ser Leu Gly Ser Pro Met Tyr Leu Ser Leu Ala Tyr Leu
    50                  55                  60                  
Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Asn Leu Ile
65                  70                  75                  80  
Thr His Ser Leu Tyr Gly Lys Lys Ala Ile Leu Phe Asn Gly Cys Met
                85                  90                  95      
Thr Gln Val Phe Gly Glu His Phe Phe Gly Gly Ala Glu Gly Ile Leu
            100                 105                 110         
Leu Thr Val Met Ala Tyr Asp His Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125             
His Tyr Met Thr Ile Met Asn Gln Cys Val Cys Ala Leu Leu Met Gly
    130                 135                 140                 
Val Val Trp Met Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe
145                 150                 155                 160 
Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met
                165                 170                 175     
Cys Asp Leu Asn Pro Leu Leu Asn Leu Ala Cys Thr Asp Thr His Met
            180                 185                 190         
Leu Glu Leu Phe Ile Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn
        195                 200                 205             
Phe Ala Leu Leu Leu Val Ser Tyr Val Val Ile Leu Cys Ser Leu Arg
    210                 215                 220                 
Thr His Ser Leu Glu Ala Arg His Lys Ala Leu Ser Thr Cys Val Ser
225                 230                 235                 240 
His Ile Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe Val Tyr
                245                 250                 255     
Met Arg Pro Ala Ala Thr Leu Pro Ile Asp Lys Ala Val Ala Ile Phe
            260                 265                 270         
Tyr Thr Met Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Lys
        275                 280                 285             
Asn Ala Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Arg Lys Asp
    290                 295                 300                 
Ile Ser Gly Asp Lys
305                 


<210> 6826
<211> 691
<212> PRT
<213> Homo sapiens

<400> 6826
Met Asp Gln Asn Gln His Leu Asn Lys Thr Ala Glu Ala Gln Pro Ser
 1               5                  10                  15      
Glu Asn Lys Lys Thr Arg Tyr Cys Asn Gly Leu Lys Met Phe Leu Ala
            20                  25                  30          
Ala Leu Ser Leu Ser Phe Ile Ala Lys Thr Leu Gly Ala Ile Ile Met
        35                  40                  45              
Lys Ser Ser Ile Ile His Ile Glu Arg Arg Phe Glu Ile Ser Ser Ser
    50                  55                  60                  
Leu Val Gly Phe Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val
65                  70                  75                  80  
Ile Val Phe Val Ser Tyr Phe Gly Ser Lys Leu His Arg Pro Lys Leu
                85                  90                  95      
Ile Gly Ile Gly Cys Phe Ile Met Gly Ile Gly Gly Val Leu Thr Ala
            100                 105                 110         
Leu Pro His Phe Phe Met Gly Tyr Tyr Arg Tyr Ser Lys Glu Thr Asn
        115                 120                 125             
Ile Asn Ser Ser Glu Asn Ser Thr Ser Thr Leu Ser Thr Cys Leu Ile
    130                 135                 140                 
Asn Gln Ile Leu Ser Leu Asn Arg Ala Ser Pro Glu Ile Val Gly Lys
145                 150                 155                 160 
Gly Cys Leu Lys Glu Ser Gly Ser Tyr Met Trp Ile Tyr Val Phe Met
                165                 170                 175     
Gly Asn Met Leu Arg Gly Ile Gly Glu Thr Pro Ile Val Pro Leu Gly
            180                 185                 190         
Leu Ser Tyr Ile Asp Asp Phe Ala Lys Glu Gly His Ser Ser Leu Tyr
        195                 200                 205             
Leu Gly Ile Leu Asn Ala Ile Ala Met Ile Gly Pro Ile Ile Gly Phe
    210                 215                 220                 
Thr Leu Gly Ser Leu Phe Ser Lys Met Tyr Val Asp Ile Gly Tyr Val
225                 230                 235                 240 
Asp Leu Ser Thr Ile Arg Ile Thr Pro Thr Asp Ser Arg Trp Val Gly
                245                 250                 255     
Ala Trp Trp Leu Asn Phe Leu Val Ser Gly Leu Phe Ser Ile Ile Ser
            260                 265                 270         
Ser Ile Pro Phe Phe Phe Leu Pro Gln Thr Pro Asn Lys Pro Gln Lys
        275                 280                 285             
Glu Arg Lys Ala Ser Leu Ser Leu His Val Leu Glu Thr Asn Asp Glu
    290                 295                 300                 
Lys Asp Gln Thr Ala Asn Leu Thr Asn Gln Gly Lys Asn Ile Thr Lys
305                 310                 315                 320 
Asn Val Thr Gly Phe Phe Gln Ser Phe Lys Ser Ile Leu Thr Asn Pro
                325                 330                 335     
Leu Tyr Val Met Phe Val Leu Leu Thr Leu Leu Gln Val Ser Ser Tyr
            340                 345                 350         
Ile Gly Ala Phe Thr Tyr Val Phe Lys Tyr Val Glu Gln Gln Tyr Gly
        355                 360                 365             
Gln Pro Ser Ser Lys Ala Asn Ile Leu Leu Gly Val Ile Thr Ile Pro
    370                 375                 380                 
Ile Phe Ala Ser Gly Met Phe Leu Gly Gly Tyr Ile Ile Lys Lys Phe
385                 390                 395                 400 
Lys Leu Asn Thr Val Gly Ile Ala Lys Phe Ser Cys Phe Thr Ala Val
                405                 410                 415     
Met Ser Leu Ser Phe Tyr Leu Leu Tyr Phe Phe Ile Leu Cys Glu Asn
            420                 425                 430         
Lys Ser Val Ala Gly Leu Thr Met Thr Tyr Asp Gly Asn Asn Pro Val
        435                 440                 445             
Thr Ser His Arg Asp Val Pro Leu Ser Tyr Cys Asn Ser Asp Cys Asn
    450                 455                 460                 
Cys Asp Glu Ser Gln Trp Glu Pro Val Cys Gly Asn Asn Gly Ile Thr
465                 470                 475                 480 
Tyr Ile Ser Pro Cys Leu Ala Gly Cys Lys Ser Ser Ser Gly Asn Lys
                485                 490                 495     
Lys Pro Ile Val Phe Tyr Asn Cys Ser Cys Leu Glu Val Thr Gly Leu
            500                 505                 510         
Gln Asn Arg Asn Tyr Ser Ala His Leu Gly Glu Cys Pro Arg Asp Asp
        515                 520                 525             
Ala Cys Thr Arg Lys Phe Tyr Phe Phe Val Ala Ile Gln Val Leu Asn
    530                 535                 540                 
Leu Phe Phe Ser Ala Leu Gly Gly Thr Ser His Val Met Leu Ile Val
545                 550                 555                 560 
Lys Ile Val Gln Pro Glu Leu Lys Ser Leu Ala Leu Gly Phe His Ser
                565                 570                 575     
Met Val Ile Arg Ala Leu Gly Gly Ile Leu Ala Pro Ile Tyr Phe Gly
            580                 585                 590         
Ala Leu Ile Asp Thr Thr Cys Ile Lys Trp Ser Thr Asn Asn Cys Gly
        595                 600                 605             
Thr Arg Gly Ser Cys Arg Thr Tyr Asn Ser Thr Ser Phe Ser Arg Val
    610                 615                 620                 
Tyr Leu Gly Leu Ser Ser Met Leu Arg Val Ser Ser Leu Val Leu Tyr
625                 630                 635                 640 
Ile Ile Leu Ile Tyr Ala Met Lys Lys Lys Tyr Gln Glu Lys Asp Ile
                645                 650                 655     
Asn Ala Ser Glu Asn Gly Ser Val Met Asp Glu Ala Asn Leu Glu Ser
            660                 665                 670         
Leu Asn Lys Asn Lys His Phe Val Pro Ser Ala Gly Ala Asp Ser Glu
        675                 680                 685             
Thr His Cys
    690     


<210> 6827
<211> 332
<212> PRT
<213> Homo sapiens

<400> 6827
Met Leu Trp Leu Phe Gln Ser Leu Leu Phe Val Phe Cys Phe Gly Pro
 1               5                  10                  15      
Gly Asn Val Val Ser Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly
            20                  25                  30          
Ile Leu Gly Glu Ser Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu
        35                  40                  45              
Lys Val Asn Phe Ile Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe
    50                  55                  60                  
Ile Val Pro His Glu Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro
65                  70                  75                  80  
Lys Gln Gly Lys Arg Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu
                85                  90                  95      
Ser Asn Leu Lys Met Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser
            100                 105                 110         
Thr Lys Thr Ser Ala Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg
        115                 120                 125             
Gln Leu Arg Asn Ile Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn
    130                 135                 140                 
Met Thr Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp
145                 150                 155                 160 
Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln
                165                 170                 175     
Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp
            180                 185                 190         
Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val
        195                 200                 205             
Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr
    210                 215                 220                 
Lys Met Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe
225                 230                 235                 240 
Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser
                245                 250                 255     
Leu Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala Arg Asn Leu
            260                 265                 270         
Glu Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val
        275                 280                 285             
Thr His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp
    290                 295                 300                 
Thr Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro
305                 310                 315                 320 
Thr Phe Ser Arg Ala Thr Ala Leu Asp Asn Val Val
                325                 330         


<210> 6828
<211> 547
<212> PRT
<213> Homo sapiens

<400> 6828
Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr
 1               5                  10                  15      
Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe
            20                  25                  30          
Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser
        35                  40                  45              
Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala
    50                  55                  60                  
Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp
65                  70                  75                  80  
Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys
                85                  90                  95      
Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr
            100                 105                 110         
Val Tyr Gly Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp
        115                 120                 125             
Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Gly Gly
    130                 135                 140                 
Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu
145                 150                 155                 160 
Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr
                165                 170                 175     
Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr
            180                 185                 190         
Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser
        195                 200                 205             
Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg
    210                 215                 220                 
Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp
225                 230                 235                 240 
Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu
                245                 250                 255     
Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp
            260                 265                 270         
Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly
        275                 280                 285             
Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu
    290                 295                 300                 
Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn
305                 310                 315                 320 
Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys
                325                 330                 335     
Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala
            340                 345                 350         
Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp
        355                 360                 365             
Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu
    370                 375                 380                 
Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro
385                 390                 395                 400 
Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys
                405                 410                 415     
Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu
            420                 425                 430         
Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile
        435                 440                 445             
Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala
    450                 455                 460                 
Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu
465                 470                 475                 480 
Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr
                485                 490                 495     
Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu
            500                 505                 510         
His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu
        515                 520                 525             
Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser
    530                 535                 540                 
Arg Ala Glu
545         


<210> 6829
<211> 331
<212> PRT
<213> Homo sapiens

<400> 6829
Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val
 1               5                  10                  15      
Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro
            20                  25                  30          
Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe
        35                  40                  45              
Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr
    50                  55                  60                  
His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys
65                  70                  75                  80  
Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr
                85                  90                  95      
Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly
            100                 105                 110         
Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu
        115                 120                 125             
Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe
    130                 135                 140                 
Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu
145                 150                 155                 160 
Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly
                165                 170                 175     
Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn
            180                 185                 190         
Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val
        195                 200                 205             
Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro
    210                 215                 220                 
Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu
225                 230                 235                 240 
Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val
                245                 250                 255     
Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu
            260                 265                 270         
Arg Asn Ser Leu Pro Lys Val Leu Arg Gln Gly Leu Ala Lys Gly Trp
        275                 280                 285             
Asn Ala Val Ala Ile His Arg Cys Ser His Asn Ala Leu Gln Ser Glu
    290                 295                 300                 
Thr Pro Glu Leu Lys Gln Ser Ser Cys Leu Ser Phe Pro Ser Ser Trp
305                 310                 315                 320 
Asp Tyr Lys Arg Ala Ser Leu Cys Pro Ser Asp
                325                 330     


<210> 6830
<211> 515
<212> PRT
<213> Homo sapiens

<400> 6830
Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val
 1               5                  10                  15      
Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro
            20                  25                  30          
Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe
        35                  40                  45              
Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr
    50                  55                  60                  
His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys
65                  70                  75                  80  
Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr
                85                  90                  95      
Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly
            100                 105                 110         
Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu
        115                 120                 125             
Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe
    130                 135                 140                 
Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu
145                 150                 155                 160 
Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly
                165                 170                 175     
Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn
            180                 185                 190         
Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val
        195                 200                 205             
Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro
    210                 215                 220                 
Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu
225                 230                 235                 240 
Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val
                245                 250                 255     
Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu
            260                 265                 270         
Arg Asn Ser Leu Pro Lys Val Leu Asn Phe His Asn Phe Leu Ala Trp
        275                 280                 285             
Pro Phe Pro Asn Leu Pro Pro Leu Glu Ala Met Asp Met Val Glu Val
    290                 295                 300                 
Ile Tyr Ile Asn Arg Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp
305                 310                 315                 320 
Glu Ser Asp Ser Asp Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly
                325                 330                 335     
Tyr Thr Met His Gly Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala
            340                 345                 350         
Thr Ser Thr Glu Ser Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro
        355                 360                 365             
Asp Leu Pro Glu Val Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser
    370                 375                 380                 
Pro Gln Gln Leu Glu Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser
385                 390                 395                 400 
Pro Leu Gln Asp Pro Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly
                405                 410                 415     
Ser Gly Gly Arg Ile Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu
            420                 425                 430         
Arg Val Leu Asp Asp Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met
        435                 440                 445             
Leu Ser Ser His Leu Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn
    450                 455                 460                 
Val Gln Ser Asn His Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr
465                 470                 475                 480 
Phe Pro Ser Pro Ser Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser
                485                 490                 495     
Asp Gln Ser Asp Thr Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr
            500                 505                 510         
Ile Met Arg
        515 


<210> 6831
<211> 423
<212> PRT
<213> Homo sapiens

<400> 6831
Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val
 1               5                  10                  15      
Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro
            20                  25                  30          
Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe
        35                  40                  45              
Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr
    50                  55                  60                  
His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys
65                  70                  75                  80  
Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr
                85                  90                  95      
Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly
            100                 105                 110         
Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu
        115                 120                 125             
Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe
    130                 135                 140                 
Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu
145                 150                 155                 160 
Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly
                165                 170                 175     
Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn
            180                 185                 190         
Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val
        195                 200                 205             
Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro
    210                 215                 220                 
Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Phe Ser Thr
225                 230                 235                 240 
Ser Gly Gly Gly Tyr Thr Met His Gly Leu Thr Val Arg Pro Leu Gly
                245                 250                 255     
Gln Ala Ser Ala Thr Ser Thr Glu Ser Gln Leu Ile Asp Pro Glu Ser
            260                 265                 270         
Glu Glu Glu Pro Asp Leu Pro Glu Val Asp Val Glu Leu Pro Thr Met
        275                 280                 285             
Pro Lys Asp Ser Pro Gln Gln Leu Glu Leu Leu Ser Gly Pro Cys Glu
    290                 295                 300                 
Arg Arg Lys Ser Pro Leu Gln Asp Pro Phe Pro Glu Glu Asp Tyr Ser
305                 310                 315                 320 
Ser Thr Glu Gly Ser Gly Gly Arg Ile Thr Phe Asn Val Asp Leu Asn
                325                 330                 335     
Ser Val Phe Leu Arg Val Leu Asp Asp Glu Asp Ser Asp Asp Leu Glu
            340                 345                 350         
Ala Pro Leu Met Leu Ser Ser His Leu Glu Glu Met Val Asp Pro Glu
        355                 360                 365             
Asp Pro Asp Asn Val Gln Ser Asn His Leu Leu Ala Ser Gly Glu Gly
    370                 375                 380                 
Thr Gln Pro Thr Phe Pro Ser Pro Ser Ser Glu Gly Leu Trp Ser Glu
385                 390                 395                 400 
Asp Ala Pro Ser Asp Gln Ser Asp Thr Ser Glu Ser Asp Val Asp Leu
                405                 410                 415     
Gly Asp Gly Tyr Ile Met Arg
            420             


<210> 6832
<211> 267
<212> PRT
<213> Homo sapiens

<400> 6832
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15      
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30          
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45              
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60                  
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80  
Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu
                85                  90                  95      
Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys
            100                 105                 110         
Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr
        115                 120                 125             
Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln
    130                 135                 140                 
Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp
145                 150                 155                 160 
Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys
                165                 170                 175     
Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe
            180                 185                 190         
Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp
        195                 200                 205             
Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu
    210                 215                 220                 
Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile
225                 230                 235                 240 
Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val
                245                 250                 255     
His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr
            260                 265         


<210> 6833
<211> 242
<212> PRT
<213> Homo sapiens

<400> 6833
Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe
 1               5                  10                  15      
Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val
            20                  25                  30          
Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser
        35                  40                  45              
Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala
    50                  55                  60                  
Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu
65                  70                  75                  80  
Val Arg Cys Leu Leu Gly Leu Leu Lys Gln Glu Met Gly Gly Ile Val
                85                  90                  95      
Thr Glu Pro Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln
            100                 105                 110         
Asp Ala Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val
        115                 120                 125             
Ser Phe Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu
    130                 135                 140                 
Val Thr Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser
145                 150                 155                 160 
Leu Ser Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln
                165                 170                 175     
Ser Gly Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met
            180                 185                 190         
Glu Lys Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly
        195                 200                 205             
Val Gly Val Gly Val Ala Ile Val Glu Leu Leu Gly Met Val Leu Ser
    210                 215                 220                 
Ile Cys Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val Pro
225                 230                 235                 240 
Lys Tyr
        


<210> 6834
<211> 157
<212> PRT
<213> Homo sapiens

<400> 6834
Met Arg Ala Val Pro Leu Pro Ala Pro Leu Leu Pro Leu Leu Leu Leu
 1               5                  10                  15      
Ala Leu Leu Ala Ala Pro Thr Ala Arg Ala Ser Arg Ala Glu Ser Val
            20                  25                  30          
Ser Ala Pro Arg Pro Glu Pro Glu Arg Glu Ser Arg Pro Pro Pro Gly
        35                  40                  45              
Pro Gly Pro Gly Asn Thr Thr Arg Phe Gly Ser Gly Ala Ala Gly Gly
    50                  55                  60                  
Ser Gly Ser Ser Asn Ser Ser Gly Asp Ala Leu Val Thr Arg Ile Ser
65                  70                  75                  80  
Ile Leu Leu Arg Asp Leu Pro Thr Leu Lys Ala Ala Val Ile Val Ala
                85                  90                  95      
Phe Ala Phe Thr Thr Leu Leu Ile Ala Cys Leu Leu Leu Arg Val Phe
            100                 105                 110         
Arg Ser Gly Lys Arg Leu Lys Lys Thr Arg Lys Tyr Asp Ile Ile Thr
        115                 120                 125             
Thr Pro Ala Glu Arg Val Glu Met Ala Pro Leu Asn Glu Glu Asp Asp
    130                 135                 140                 
Glu Asp Glu Asp Ser Thr Val Phe Asp Ile Lys Tyr Arg
145                 150                 155         


<210> 6835
<211> 575
<212> PRT
<213> Homo sapiens

<400> 6835
Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg
 1               5                  10                  15      
Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe
            20                  25                  30          
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala
        35                  40                  45              
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile
    50                  55                  60                  
Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val
65                  70                  75                  80  
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys
                85                  90                  95      
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly
            100                 105                 110         
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe
        115                 120                 125             
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val
    130                 135                 140                 
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys
145                 150                 155                 160 
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala
                165                 170                 175     
Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys
            180                 185                 190         
Val Gly Arg Lys Gly Val Ile Thr Val Lys Ala Ser Asp Gly Lys Thr
        195                 200                 205             
Leu Asn Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly
    210                 215                 220                 
Tyr Ile Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu
225                 230                 235                 240 
Phe Gln Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile
                245                 250                 255     
Gln Ser Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro
            260                 265                 270         
Leu Val Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu
        275                 280                 285             
Val Leu Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala
    290                 295                 300                 
Pro Gly Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile
305                 310                 315                 320 
Ala Thr Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu
                325                 330                 335     
Glu Asp Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val
            340                 345                 350         
Thr Lys Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln
        355                 360                 365             
Ile Glu Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr
    370                 375                 380                 
Ser Glu Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser
385                 390                 395                 400 
Asp Gly Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val
                405                 410                 415     
Asn Glu Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala
            420                 425                 430         
Ala Val Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg
        435                 440                 445             
Cys Ile Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys
    450                 455                 460                 
Ile Gly Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr
465                 470                 475                 480 
Ile Ala Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile
                485                 490                 495     
Met Gln Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe
            500                 505                 510         
Val Asn Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg
        515                 520                 525             
Thr Ala Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala
    530                 535                 540                 
Glu Val Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met
545                 550                 555                 560 
Gly Ala Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe
                565                 570                 575 


<210> 6836
<211> 217
<212> PRT
<213> Homo sapiens

<400> 6836
Val Ser Leu Ser Ser Gln Arg Arg Ala Met Gly Ile Ser Arg Asp Asn
 1               5                  10                  15      
Trp His Lys Arg Arg Lys Thr Gly Gly Lys Arg Lys Pro Tyr His Lys
            20                  25                  30          
Lys Arg Lys Tyr Glu Leu Gly Arg Pro Ala Ala Asn Thr Lys Ile Gly
        35                  40                  45              
Pro Arg Arg Ile His Thr Val Arg Val Arg Gly Gly Asn Lys Lys Tyr
    50                  55                  60                  
Arg Ala Leu Arg Leu Asp Val Gly Asn Phe Ser Trp Gly Ser Glu Cys
65                  70                  75                  80  
Cys Thr Arg Lys Thr Arg Ile Ile Asp Val Val Tyr Asn Ala Ser Asn
                85                  90                  95      
Asn Glu Leu Val Arg Thr Lys Thr Leu Val Lys Asn Cys Ile Val Leu
            100                 105                 110         
Ile Asp Ser Thr Pro Tyr Arg Gln Trp Tyr Glu Ser His Tyr Ala Leu
        115                 120                 125             
Pro Leu Gly Arg Lys Lys Gly Ala Lys Leu Thr Pro Glu Glu Glu Glu
    130                 135                 140                 
Ile Leu Asn Lys Lys Arg Ser Lys Lys Ile Gln Lys Lys Tyr Asp Glu
145                 150                 155                 160 
Arg Lys Lys Asn Ala Lys Ile Ser Ser Leu Leu Glu Glu Gln Phe Gln
                165                 170                 175     
Gln Gly Lys Leu Leu Ala Cys Ile Ala Ser Arg Pro Gly Gln Cys Gly
            180                 185                 190         
Arg Ala Asp Gly Tyr Val Leu Glu Gly Lys Glu Leu Glu Phe Tyr Leu
        195                 200                 205             
Arg Lys Ile Lys Ala Arg Lys Gly Lys
    210                 215         


<210> 6837
<211> 221
<212> PRT
<213> Homo sapiens

<400> 6837
Met Ser Glu Thr Ala Pro Leu Ala Pro Thr Ile Pro Ala Pro Ala Glu
 1               5                  10                  15      
Lys Thr Pro Val Lys Lys Lys Ala Lys Lys Ala Gly Ala Thr Ala Gly
            20                  25                  30          
Lys Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala
        35                  40                  45              
Val Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys
    50                  55                  60                  
Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg
65                  70                  75                  80  
Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln
                85                  90                  95      
Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala
            100                 105                 110         
Ala Ser Gly Glu Gly Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala Lys
        115                 120                 125             
Pro Arg Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Val Ala Gly
    130                 135                 140                 
Ala Ala Thr Pro Lys Lys Ser Ile Lys Lys Thr Pro Lys Lys Val Lys
145                 150                 155                 160 
Lys Pro Ala Thr Ala Ala Gly Thr Lys Lys Val Ala Lys Ser Ala Lys
                165                 170                 175     
Lys Val Lys Thr Pro Gln Pro Lys Lys Ala Ala Lys Ser Pro Ala Lys
            180                 185                 190         
Ala Lys Ala Pro Lys Pro Lys Ala Ala Lys Pro Lys Ser Gly Lys Pro
        195                 200                 205             
Lys Val Thr Lys Ala Lys Lys Ala Ala Pro Lys Lys Lys
    210                 215                 220     


<210> 6838
<211> 213
<212> PRT
<213> Homo sapiens

<400> 6838
Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Ala Pro Pro Ala Glu
 1               5                  10                  15      
Lys Ala Pro Val Lys Lys Lys Ala Ala Lys Lys Ala Gly Gly Thr Pro
            20                  25                  30          
Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val
        35                  40                  45              
Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys
    50                  55                  60                  
Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile
65                  70                  75                  80  
Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr
                85                  90                  95      
Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala
            100                 105                 110         
Ser Gly Glu Ala Lys Pro Lys Val Lys Lys Ala Gly Gly Thr Lys Pro
        115                 120                 125             
Lys Lys Pro Val Gly Ala Ala Lys Lys Pro Lys Lys Ala Ala Gly Gly
    130                 135                 140                 
Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys
145                 150                 155                 160 
Pro Ala Ala Ala Thr Val Thr Lys Lys Val Ala Lys Ser Pro Lys Lys
                165                 170                 175     
Ala Lys Val Ala Lys Pro Lys Lys Ala Ala Lys Ser Ala Ala Lys Ala
            180                 185                 190         
Val Lys Pro Lys Ala Ala Lys Pro Lys Val Val Lys Pro Lys Lys Ala
        195                 200                 205             
Ala Pro Lys Lys Lys
    210             


<210> 6839
<211> 219
<212> PRT
<213> Homo sapiens

<400> 6839
Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu
 1               5                  10                  15      
Lys Thr Pro Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala Lys
            20                  25                  30          
Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val
        35                  40                  45              
Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys
    50                  55                  60                  
Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile
65                  70                  75                  80  
Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr
                85                  90                  95      
Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala
            100                 105                 110         
Ser Gly Glu Ala Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala Lys Ala
        115                 120                 125             
Lys Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Ala Thr Gly Ala
    130                 135                 140                 
Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys
145                 150                 155                 160 
Pro Ala Ala Ala Ala Gly Ala Lys Lys Ala Lys Ser Pro Lys Lys Ala
                165                 170                 175     
Lys Ala Ala Lys Pro Lys Lys Ala Pro Lys Ser Pro Ala Lys Ala Lys
            180                 185                 190         
Ala Val Lys Pro Lys Ala Ala Lys Pro Lys Thr Ala Lys Pro Lys Ala
        195                 200                 205             
Ala Lys Pro Lys Lys Ala Ala Ala Lys Lys Lys
    210                 215                 


<210> 6840
<211> 215
<212> PRT
<213> Homo sapiens

<400> 6840
Met Ser Glu Thr Val Pro Pro Ala Pro Ala Ala Ser Ala Ala Pro Glu
 1               5                  10                  15      
Lys Pro Leu Ala Gly Lys Lys Ala Lys Lys Pro Ala Lys Ala Ala Ala
            20                  25                  30          
Ala Ser Lys Lys Lys Pro Ala Gly Pro Ser Val Ser Glu Leu Ile Val
        35                  40                  45              
Gln Ala Ala Ser Ser Ser Lys Glu Arg Gly Gly Val Ser Leu Ala Ala
    50                  55                  60                  
Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn
65                  70                  75                  80  
Ser Arg Ile Lys Leu Gly Ile Lys Ser Leu Val Ser Lys Gly Thr Leu
                85                  90                  95      
Val Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys
            100                 105                 110         
Lys Ala Ser Ser Val Glu Thr Lys Pro Gly Ala Ser Lys Val Ala Thr
        115                 120                 125             
Lys Thr Lys Ala Thr Gly Ala Ser Lys Lys Leu Lys Lys Ala Thr Gly
    130                 135                 140                 
Ala Ser Lys Lys Ser Val Lys Thr Pro Lys Lys Ala Lys Lys Pro Ala
145                 150                 155                 160 
Ala Thr Arg Lys Ser Ser Lys Asn Pro Lys Lys Pro Lys Thr Val Lys
                165                 170                 175     
Pro Lys Lys Val Ala Lys Ser Pro Ala Lys Ala Lys Ala Val Lys Pro
            180                 185                 190         
Lys Ala Ala Lys Ala Arg Val Thr Lys Pro Lys Thr Ala Lys Pro Lys
        195                 200                 205             
Lys Ala Ala Pro Lys Lys Lys
    210                 215 


<210> 6841
<211> 207
<212> PRT
<213> Homo sapiens

<400> 6841
Met Ser Glu Thr Val Pro Ala Ala Ser Ala Ser Ala Gly Val Ala Ala
 1               5                  10                  15      
Met Glu Lys Leu Pro Thr Lys Lys Arg Gly Arg Lys Pro Ala Gly Leu
            20                  25                  30          
Ile Ser Ala Ser Arg Lys Val Pro Asn Leu Ser Val Ser Lys Leu Ile
        35                  40                  45              
Thr Glu Ala Leu Ser Val Ser Gln Glu Arg Val Gly Met Ser Leu Val
    50                  55                  60                  
Ala Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn
65                  70                  75                  80  
Asn Ser Arg Ile Lys Leu Ser Leu Lys Ser Leu Val Asn Lys Gly Ile
                85                  90                  95      
Leu Val Gln Thr Arg Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Ser
            100                 105                 110         
Lys Lys Val Ile Pro Lys Ser Thr Arg Ser Lys Ala Lys Lys Ser Val
        115                 120                 125             
Ser Ala Lys Thr Lys Lys Leu Val Leu Ser Arg Asp Ser Lys Ser Pro
    130                 135                 140                 
Lys Thr Ala Lys Thr Asn Lys Arg Ala Lys Lys Pro Arg Ala Thr Thr
145                 150                 155                 160 
Pro Lys Thr Val Arg Ser Gly Arg Lys Ala Lys Gly Ala Lys Gly Lys
                165                 170                 175     
Gln Gln Gln Lys Ser Pro Val Lys Ala Arg Ala Ser Lys Ser Lys Leu
            180                 185                 190         
Thr Gln His His Glu Val Asn Val Arg Lys Ala Thr Ser Lys Lys
        195                 200                 205         


<210> 6842
<211> 238
<212> PRT
<213> Homo sapiens

<400> 6842
Met Leu Thr Thr Leu Leu Pro Ile Leu Leu Leu Ser Gly Trp Ala Phe
 1               5                  10                  15      
Cys Ser Gln Asp Ala Ser Asp Gly Leu Gln Arg Leu His Met Leu Gln
            20                  25                  30          
Ile Ser Tyr Phe Arg Asp Pro Tyr His Val Trp Tyr Gln Gly Asn Ala
        35                  40                  45              
Ser Leu Gly Gly His Leu Thr His Val Leu Glu Gly Pro Asp Thr Asn
    50                  55                  60                  
Thr Thr Ile Ile Gln Leu Gln Pro Leu Gln Glu Pro Glu Ser Trp Ala
65                  70                  75                  80  
Arg Thr Gln Ser Gly Leu Gln Ser Tyr Leu Leu Gln Phe His Gly Leu
                85                  90                  95      
Val Arg Leu Val His Gln Glu Arg Thr Leu Ala Phe Pro Leu Thr Ile
            100                 105                 110         
Arg Cys Phe Leu Gly Cys Glu Leu Pro Pro Glu Gly Ser Arg Ala His
        115                 120                 125             
Val Phe Phe Glu Val Ala Val Asn Gly Ser Ser Phe Val Ser Phe Arg
    130                 135                 140                 
Pro Glu Arg Ala Leu Trp Gln Ala Asp Thr Gln Val Thr Ser Gly Val
145                 150                 155                 160 
Val Thr Phe Thr Leu Gln Gln Leu Asn Ala Tyr Asn Arg Thr Arg Tyr
                165                 170                 175     
Glu Leu Arg Glu Phe Leu Glu Asp Thr Cys Val Gln Tyr Val Gln Lys
            180                 185                 190         
His Ile Ser Ala Glu Asn Thr Lys Gly Ser Gln Thr Ser Arg Ser Tyr
        195                 200                 205             
Thr Ser Leu Val Leu Gly Val Leu Val Gly Ser Phe Ile Ile Ala Gly
    210                 215                 220                 
Val Ala Val Gly Ile Phe Leu Cys Thr Gly Gly Arg Arg Cys
225                 230                 235             


<210> 6843
<211> 825
<212> PRT
<213> Homo sapiens

<400> 6843
Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val
 1               5                  10                  15      
Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro
            20                  25                  30          
Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met
        35                  40                  45              
Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu
    50                  55                  60                  
Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly
65                  70                  75                  80  
Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala
                85                  90                  95      
Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys
            100                 105                 110         
Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn
        115                 120                 125             
Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser
    130                 135                 140                 
Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala
145                 150                 155                 160 
Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn
                165                 170                 175     
Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys
            180                 185                 190         
Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr
        195                 200                 205             
Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser
    210                 215                 220                 
Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser
225                 230                 235                 240 
Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr
                245                 250                 255     
Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser
            260                 265                 270         
Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu
        275                 280                 285             
Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn
    290                 295                 300                 
Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg
305                 310                 315                 320 
Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser
                325                 330                 335     
Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp
            340                 345                 350         
Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro
        355                 360                 365             
Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe
    370                 375                 380                 
Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu
385                 390                 395                 400 
Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly
                405                 410                 415     
Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu
            420                 425                 430         
Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe
        435                 440                 445             
Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro
    450                 455                 460                 
Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp
465                 470                 475                 480 
Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala
                485                 490                 495     
Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu
            500                 505                 510         
Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro
        515                 520                 525             
Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln
    530                 535                 540                 
Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln
545                 550                 555                 560 
His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln
                565                 570                 575     
Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val
            580                 585                 590         
Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser
        595                 600                 605             
Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala
    610                 615                 620                 
Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly
625                 630                 635                 640 
Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly
                645                 650                 655     
Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser
            660                 665                 670         
Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp
        675                 680                 685             
Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val
    690                 695                 700                 
Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu
705                 710                 715                 720 
Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr
                725                 730                 735     
Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser
            740                 745                 750         
Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly
        755                 760                 765             
Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly
    770                 775                 780                 
Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly
785                 790                 795                 800 
Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser
                805                 810                 815     
Val Gly Pro Thr Tyr Met Arg Val Ser
            820                 825 


<210> 6844
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 6844
Met Phe Pro Thr Glu Ser Ala Trp Leu Gly Lys Arg Gly Ala Asn Pro
 1               5                  10                  15      
Gly Pro Glu Ala Ala Val Arg Glu Thr Val Met Leu Leu Leu Cys Leu
            20                  25                  30          
Gly Val Pro Thr Gly Arg Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu
        35                  40                  45              
Leu Tyr Gln Gly Pro His Asn Thr Leu Phe Gly Tyr Ser Val Val Leu
    50                  55                  60                  
His Ser His Gly Ala Asn Arg Trp Leu Leu Val Gly Ala Pro Thr Ala
65                  70                  75                  80  
Asn Trp Leu Ala Asn Ala Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg
                85                  90                  95      
Cys Arg Ile Gly Lys Asn Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu
            100                 105                 110         
Gly Ser Pro Asn Gly Glu Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg
        115                 120                 125             
Asp Asn Gln Trp Leu Gly Val Thr Leu Ser Arg Gln Pro Gly Glu Asn
    130                 135                 140                 
Gly Ser Ile Val Thr Cys Gly His Arg Trp Lys Asn Ile Phe Tyr Ile
145                 150                 155                 160 
Lys Asn Glu Asn Lys Leu Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro
                165                 170                 175     
Asp Leu Arg Thr Glu Leu Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp
            180                 185                 190         
Tyr Val Lys Lys Phe Gly Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile
        195                 200                 205             
Ser Ser Phe Tyr Thr Lys Asp Leu Ile Val Met Gly Ala Pro Gly Ser
    210                 215                 220                 
Ser Tyr Trp Thr Gly Ser Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys
225                 230                 235                 240 
Tyr Lys Ala Phe Leu Asp Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr
                245                 250                 255     
Leu Gly Tyr Ser Val Gly Ala Gly His Phe Arg Ser Gln His Thr Thr
            260                 265                 270         
Glu Val Val Gly Gly Ala Pro Gln His Glu Gln Ile Gly Lys Ala Tyr
        275                 280                 285             
Ile Phe Ser Ile Asp Glu Lys Glu Leu Asn Ile Leu His Glu Met Lys
    290                 295                 300                 
Gly Lys Lys Leu Gly Ser Tyr Phe Gly Ala Ser Val Cys Ala Val Asp
305                 310                 315                 320 
Leu Asn Ala Asp Gly Phe Ser Asp Leu Leu Val Gly Ala Pro Met Gln
                325                 330                 335     
Ser Thr Ile Arg Glu Glu Gly Arg Val Phe Val Tyr Ile Asn Ser Gly
            340                 345                 350         
Ser Gly Ala Val Met Asn Ala Met Glu Thr Asn Leu Val Gly Ser Asp
        355                 360                 365             
Lys Tyr Ala Ala Arg Phe Gly Glu Ser Ile Val Asn Leu Gly Asp Ile
    370                 375                 380                 
Asp Asn Asp Gly Phe Glu Asp Val Ala Ile Gly Ala Pro Gln Glu Asp
385                 390                 395                 400 
Asp Leu Gln Gly Ala Ile Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile
                405                 410                 415     
Ser Ser Thr Phe Ser Gln Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser
            420                 425                 430         
Leu Ser Met Phe Gly Gln Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn
        435                 440                 445             
Asn Gly Tyr Val Asp Val Ala Val Gly Ala Phe Arg Ser Asp Ser Ala
    450                 455                 460                 
Val Leu Leu Arg Thr Arg Pro Val Val Ile Val Asp Ala Ser Leu Ser
465                 470                 475                 480 
His Pro Glu Ser Val Asn Arg Thr Lys Phe Asp Cys Val Glu Asn Gly
                485                 490                 495     
Trp Pro Ser Val Cys Ile Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly
            500                 505                 510         
Lys Glu Val Pro Gly Tyr Ile Val Leu Phe Tyr Asn Met Ser Leu Asp
        515                 520                 525             
Val Asn Arg Lys Ala Glu Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn
    530                 535                 540                 
Gly Thr Ser Asp Val Ile Thr Gly Ser Ile Gln Val Ser Ser Arg Glu
545                 550                 555                 560 
Ala Asn Cys Arg Thr His Gln Ala Phe Met Arg Lys Asp Val Arg Asp
                565                 570                 575     
Ile Leu Thr Pro Ile Gln Ile Glu Ala Ala Tyr His Leu Gly Pro His
            580                 585                 590         
Val Ile Ser Lys Arg Ser Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile
        595                 600                 605             
Leu Gln Gln Lys Lys Glu Lys Asp Ile Met Lys Lys Thr Ile Asn Phe
    610                 615                 620                 
Ala Arg Phe Cys Ala His Glu Asn Cys Ser Ala Asp Leu Gln Val Ser
625                 630                 635                 640 
Ala Lys Ile Gly Phe Leu Lys Pro His Glu Asn Lys Thr Tyr Leu Ala
                645                 650                 655     
Val Gly Ser Met Lys Thr Leu Met Leu Asn Val Ser Leu Phe Asn Ala
            660                 665                 670         
Gly Asp Asp Ala Tyr Glu Thr Thr Leu His Val Lys Leu Pro Val Gly
        675                 680                 685             
Leu Tyr Phe Ile Lys Ile Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys
    690                 695                 700                 
Glu Val Thr Asp Asn Ser Gly Val Val Gln Leu Asp Cys Ser Ile Gly
705                 710                 715                 720 
Tyr Ile Tyr Val Asp His Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu
                725                 730                 735     
Asp Val Ser Ser Leu Ser Arg Ala Glu Glu Asp Leu Ser Ile Thr Val
            740                 745                 750         
His Ala Thr Cys Glu Asn Glu Glu Glu Met Asp Asn Leu Lys His Ser
        755                 760                 765             
Arg Val Thr Val Ala Ile Pro Leu Lys Tyr Glu Val Lys Leu Thr Val
    770                 775                 780                 
His Gly Phe Val Asn Pro Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu
785                 790                 795                 800 
Asn Glu Pro Glu Thr Cys Met Val Glu Lys Met Asn Leu Thr Phe His
                805                 810                 815     
Val Ile Asn Thr Gly Asn Ser Met Ala Pro Asn Val Ser Val Glu Ile
            820                 825                 830         
Met Val Pro Asn Ser Phe Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile
        835                 840                 845             
Leu Asp Val Gln Thr Thr Thr Gly Glu Cys His Phe Glu Asn Tyr Gln
    850                 855                 860                 
Arg Val Cys Ala Leu Glu Gln Gln Lys Ser Ala Met Gln Thr Leu Lys
865                 870                 875                 880 
Gly Ile Val Arg Phe Leu Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys
                885                 890                 895     
Ile Lys Ala Asp Pro His Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys
            900                 905                 910         
Met Glu Ser Gly Lys Glu Ala Ser Val His Ile Gln Leu Glu Gly Arg
        915                 920                 925             
Pro Ser Ile Leu Glu Met Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile
    930                 935                 940                 
Arg Ala Thr Gly Phe Pro Glu Pro Asn Pro Arg Val Ile Glu Leu Asn
945                 950                 955                 960 
Lys Asp Glu Asn Val Ala His Val Leu Leu Glu Gly Leu His His Gln
                965                 970                 975     
Arg Pro Lys Arg Tyr Phe Thr Ile Val Ile Ile Ser Ser Ser Leu Leu
            980                 985                 990         
Leu Gly Leu Ile Val Leu Leu Leu Ile Ser Tyr Val Met Trp Lys Ala
        995                 1000                1005            
Gly Phe Phe Lys Arg Gln Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg
    1010                1015                1020                
Arg Asp Ser Trp Ser Tyr Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030                1035            


<210> 6845
<211> 1709
<212> PRT
<213> Homo sapiens

<400> 6845
Met Ser Thr Leu Gly Tyr Asp Ser Leu Glu Cys Val Phe Val Phe Trp
 1               5                  10                  15      
Val Thr Asn Ser Asn Leu Glu Ser Ser Arg Met Tyr Asp Val Leu Glu
            20                  25                  30          
Pro Gln Gln Gly Arg Gly Cys Gly Ser Ser Gly Ser Gly Pro Gly Asn
        35                  40                  45              
Ser Ile Thr Ala Cys Lys Lys Val Leu Arg Ser Asn Ser Leu Leu Glu
    50                  55                  60                  
Ser Thr Asp Tyr Trp Leu Gln Asn Gln Arg Met Pro Cys Gln Ile Gly
65                  70                  75                  80  
Phe Val Glu Asp Lys Ser Glu Asn Cys Ala Ser Val Cys Phe Val Asn
                85                  90                  95      
Leu Asp Val Asn Lys Asp Glu Cys Ser Thr Glu His Leu Gln Gln Lys
            100                 105                 110         
Leu Val Asn Val Ser Pro Asp Leu Pro Lys Leu Ile Ser Ser Met Asn
        115                 120                 125             
Val Gln Gln Pro Lys Glu Asn Glu Ile Val Val Leu Ser Gly Leu Ala
    130                 135                 140                 
Ser Gly Asn Leu Gln Ala Asp Phe Glu Val Ser Gln Cys Pro Trp Leu
145                 150                 155                 160 
Pro Asp Ile Cys Leu Val Gln Cys Ala Arg Gly Asn Arg Pro Asn Ser
                165                 170                 175     
Thr Asn Cys Ile Ile Phe Glu Ile Asn Lys Phe Leu Ile Gly Leu Glu
            180                 185                 190         
Leu Val Gln Glu Arg Gln Leu His Leu Glu Thr Asn Ile Leu Lys Leu
        195                 200                 205             
Glu Asp Asp Thr Asn Cys Ser Leu Ser Ser Ile Glu Glu Asp Phe Leu
    210                 215                 220                 
Thr Ala Ser Glu His Leu Glu Glu Glu Ser Glu Val Asp Glu Ser Arg
225                 230                 235                 240 
Asn Asp Tyr Glu Asn Ile Asn Val Ser Ala Asn Val Leu Glu Ser Lys
                245                 250                 255     
Gln Leu Lys Gly Ala Thr Gln Val Glu Trp Asn Cys Asn Lys Glu Lys
            260                 265                 270         
Trp Leu Tyr Ala Leu Glu Asp Lys Tyr Ile Asn Lys Tyr Pro Thr Pro
        275                 280                 285             
Leu Ile Lys Thr Glu Arg Ser Pro Glu Asn Leu Thr Lys Asn Thr Ala
    290                 295                 300                 
Leu Gln Ser Leu Asp Pro Ser Ala Lys Pro Ser Gln Trp Lys Arg Glu
305                 310                 315                 320 
Ala Val Gly Asn Gly Arg Gln Ala Thr His Tyr Tyr His Ser Glu Ala
                325                 330                 335     
Phe Lys Gly Gln Met Glu Lys Ser Gln Ala Leu Tyr Ile Pro Lys Asp
            340                 345                 350         
Ala Tyr Phe Ser Met Met Asp Lys Asp Val Pro Ser Ala Cys Ala Val
        355                 360                 365             
Ala Glu Gln Arg Ser Asn Leu Asn Pro Gly Asp His Glu Asp Thr Arg
    370                 375                 380                 
Asn Ala Leu Pro Pro Arg Gln Asp Gly Glu Val Thr Thr Gly Lys Tyr
385                 390                 395                 400 
Ala Thr Asn Leu Ala Glu Ser Val Leu Gln Asp Ala Phe Ile Arg Leu
                405                 410                 415     
Ser Gln Ser Gln Ser Thr Leu Pro Gln Glu Ser Ala Val Ser Val Ser
            420                 425                 430         
Val Gly Ser Ser Leu Leu Pro Ser Cys Tyr Ser Thr Lys Asp Thr Val
        435                 440                 445             
Val Ser Arg Ser Trp Asn Glu Leu Pro Lys Ile Val Val Val Gln Ser
    450                 455                 460                 
Pro Asp Gly Ser Asp Ala Ala Pro Gln Pro Gly Ile Ser Ser Trp Pro
465                 470                 475                 480 
Glu Met Glu Val Ser Val Glu Thr Ser Ser Ile Leu Ser Gly Glu Asn
                485                 490                 495     
Ser Ser Arg Gln Pro Gln Ser Ala Leu Glu Val Ala Leu Ala Cys Ala
            500                 505                 510         
Ala Thr Val Ile Gly Thr Ile Ser Ser Pro Gln Ala Thr Glu Arg Leu
        515                 520                 525             
Lys Met Glu Gln Val Val Ser Asn Phe Pro Pro Gly Ser Ser Gly Ala
    530                 535                 540                 
Leu Gln Thr Gln Ala Pro Gln Gly Leu Lys Glu Pro Ser Ile Asn Glu
545                 550                 555                 560 
Tyr Ser Phe Pro Ser Ala Leu Cys Gly Met Thr Gln Val Ala Ser Ala
                565                 570                 575     
Val Ala Val Cys Gly Leu Gly Glu Arg Glu Glu Val Thr Cys Ser Val
            580                 585                 590         
Ala Pro Ser Gly Ser Leu Pro Pro Ala Ala Glu Ala Ser Glu Ala Met
        595                 600                 605             
Pro Pro Leu Cys Gly Leu Ala Ser Met Glu Leu Gly Lys Glu Ala Ile
    610                 615                 620                 
Ala Lys Gly Leu Leu Lys Glu Ala Ala Leu Val Leu Thr Arg Pro Asn
625                 630                 635                 640 
Thr Tyr Ser Ser Ile Gly Asp Phe Leu Asp Ser Met Asn Arg Arg Ile
                645                 650                 655     
Met Glu Thr Ala Ser Lys Ser Gln Thr Leu Cys Ser Glu Asn Val Val
            660                 665                 670         
Arg Asn Glu Leu Ala His Thr Leu Ser Asn Val Ile Leu Arg His Ser
        675                 680                 685             
Ile Asp Glu Val His His Lys Asn Met Ile Ile Asp Pro Asn Asp Asn
    690                 695                 700                 
Arg His Ser Ser Glu Ile Leu Asp Thr Leu Met Glu Ser Thr Asn Gln
705                 710                 715                 720 
Leu Leu Leu Asp Val Ile Cys Phe Thr Phe Lys Lys Met Ser His Ile
                725                 730                 735     
Val Arg Leu Gly Glu Cys Pro Ala Val Leu Ser Lys Glu Thr Ile Arg
            740                 745                 750         
Arg Arg Glu Thr Glu Pro Ser Cys Gln Pro Ser Asp Pro Gly Ala Ser
        755                 760                 765             
Gln Ala Trp Thr Lys Ala Thr Glu Ser Ser Ser Ser Ser Pro Leu Ser
    770                 775                 780                 
Asn Ser His Asn Thr Ser Leu Val Ile Asn Asn Leu Val Asp Gly Met
785                 790                 795                 800 
Tyr Ser Lys Gln Asp Lys Gly Gly Val Arg Pro Gly Leu Phe Lys Asn
                805                 810                 815     
Pro Thr Leu Gln Ser Gln Leu Ser Arg Ser His Arg Val Pro Asp Ser
            820                 825                 830         
Ser Thr Ala Thr Thr Ser Ser Lys Glu Ile Tyr Leu Lys Gly Ile Ala
        835                 840                 845             
Gly Glu Asp Thr Lys Ser Pro His His Ser Glu Asn Glu Cys Arg Ala
    850                 855                 860                 
Ser Ser Glu Gly Gln Arg Ser Pro Thr Val Ser Gln Ser Arg Ser Gly
865                 870                 875                 880 
Ser Gln Glu Ala Glu Glu Ser Ile His Pro Asn Thr Gln Glu Lys Tyr
                885                 890                 895     
Asn Cys Ala Thr Ser Arg Ile Asn Glu Val Gln Val Asn Leu Ser Leu
            900                 905                 910         
Leu Gly Asp Asp Leu Leu Leu Pro Ala Gln Ser Thr Leu Gln Thr Lys
        915                 920                 925             
His Pro Asp Ile Tyr Cys Ile Thr Asp Phe Ala Glu Glu Leu Ala Asp
    930                 935                 940                 
Thr Val Val Ser Met Ala Thr Glu Ile Ala Ala Ile Cys Leu Asp Asn
945                 950                 955                 960 
Ser Ser Gly Lys Gln Pro Trp Phe Cys Ala Trp Lys Arg Gly Ser Glu
                965                 970                 975     
Phe Leu Met Thr Pro Asn Val Pro Cys Arg Ser Leu Lys Arg Lys Lys
            980                 985                 990         
Glu Ser Gln Gly Ser Gly Thr Ala Val Arg Lys His Lys Pro Pro Arg
        995                 1000                1005            
Leu Ser Glu Ile Lys Arg Lys Thr Asp Glu His Pro Glu Leu Lys Glu
    1010                1015                1020                
Lys Leu Met Asn Arg Val Val Asp Glu Ser Met Asn Leu Glu Asp Val
1025                1030                1035                1040
Pro Asp Ser Val Asn Leu Phe Ala Asn Glu Val Ala Ala Lys Ile Met
                1045                1050                1055    
Asn Leu Thr Glu Phe Ser Met Val Asp Gly Met Trp Gln Ala Gln Gly
            1060                1065                1070        
Tyr Pro Arg Asn Arg Leu Leu Ser Gly Asp Arg Trp Ser Arg Leu Lys
        1075                1080                1085            
Ala Ser Ser Cys Glu Ser Ile Pro Glu Glu Asp Ser Glu Ala Arg Ala
    1090                1095                1100                
Tyr Val Asn Ser Leu Gly Leu Met Ser Thr Leu Ser Gln Pro Val Ser
1105                1110                1115                1120
Arg Ala Ser Ser Val Ser Lys Gln Ser Ser Cys Glu Ser Ile Thr Asp
                1125                1130                1135    
Glu Phe Ser Arg Phe Met Val Asn Gln Met Glu Asn Glu Gly Arg Gly
            1140                1145                1150        
Phe Glu Leu Leu Leu Asp Tyr Tyr Ala Gly Lys Asn Ala Ser Ser Ile
        1155                1160                1165            
Leu Asn Ser Ala Met Gln Gln Ala Cys Arg Lys Ser Asp His Leu Ser
    1170                1175                1180                
Val Arg Pro Ser Cys Pro Ser Lys Gln Ser Ser Thr Glu Ser Ile Thr
1185                1190                1195                1200
Glu Glu Phe Tyr Arg Tyr Met Leu Arg Asp Ile Glu Arg Asp Ser Arg
                1205                1210                1215    
Glu Ser Ala Ser Ser Arg Arg Ser Ser Gln Asp Trp Thr Ala Gly Leu
            1220                1225                1230        
Leu Ser Pro Ser Leu Arg Ser Pro Val Cys His Arg Gln Ser Ser Met
        1235                1240                1245            
Pro Asp Ser Arg Ser Pro Cys Ser Arg Leu Thr Val Asn Val Pro Ile
    1250                1255                1260                
Lys Ala Asn Ser Leu Asp Gly Phe Ala Gln Asn Cys Pro Gln Asp Phe
1265                1270                1275                1280
Leu Ser Val Gln Pro Val Ser Ser Ala Ser Ser Ser Gly Leu Cys Lys
                1285                1290                1295    
Ser Asp Ser Cys Leu Tyr Arg Arg Gly Gly Thr Asp His Ile Thr Asn
            1300                1305                1310        
Met Leu Ile His Glu Thr Trp Ala Ser Ser Ile Glu Ala Leu Met Arg
        1315                1320                1325            
Lys Asn Lys Ile Ile Val Asp Asp Ala Glu Glu Ala Asp Thr Glu Pro
    1330                1335                1340                
Val Ser Gly Gly Ser Pro Ser Gln Ala Glu Lys Cys Ala Asn Arg Leu
1345                1350                1355                1360
Ala Ala Ser Arg Met Cys Ser Gly Pro Thr Leu Leu Val Gln Glu Ser
                1365                1370                1375    
Leu Asp Cys Pro Arg Lys Asp Ser Val Thr Glu Cys Lys Gln Pro Pro
            1380                1385                1390        
Val Ser Ser Leu Ser Lys Thr Ala Ser Leu Thr Asn His Ser Pro Leu
        1395                1400                1405            
Asp Ser Lys Lys Glu Thr Ser Ser Cys Gln Asp Pro Val Pro Ile Asn
    1410                1415                1420                
His Lys Arg Arg Ser Leu Cys Ser Arg Glu Val Pro Leu Ile Gln Ile
1425                1430                1435                1440
Glu Thr Asp Gln Arg Glu Ala Cys Ala Gly Glu Pro Glu Pro Phe Leu
                1445                1450                1455    
Ser Lys Ser Ser Leu Leu Glu Glu Ala Glu Gly His Ser Asn Asp Lys
            1460                1465                1470        
Asn Ile Pro Asp Val Val Arg Gly Gly Asp Thr Ala Val Ser Ala Cys
        1475                1480                1485            
Gln Ile His Ser Asp Ser Leu Asp Thr Arg Asp Val Pro Glu Ala Glu
    1490                1495                1500                
Ala Ser Thr Glu Ala Arg Ala Pro Asp Glu Ala Pro Asn Pro Pro Ser
1505                1510                1515                1520
Ser Ser Glu Glu Ser Thr Gly Ser Trp Thr Gln Leu Ala Asn Glu Glu
                1525                1530                1535    
Asp Asn Pro Asp Asp Thr Ser Ser Phe Leu Gln Leu Ser Glu Arg Ser
            1540                1545                1550        
Met Ser Asn Gly Asn Ser Ser Ala Thr Ser Ser Leu Gly Ile Met Asp
        1555                1560                1565            
Leu Asp Ile Tyr Gln Glu Ser Met Pro Ser Ser Pro Met Ile Asn Glu
    1570                1575                1580                
Leu Val Glu Glu Lys Lys Ile Leu Lys Gly Gln Ser Glu Ser Thr Glu
1585                1590                1595                1600
Ala Pro Ala Ser Gly Pro Pro Thr Gly Thr Ala Ser Pro Gln Arg Ser
                1605                1610                1615    
Leu Leu Val Ile Asn Phe Asp Leu Glu Pro Glu Cys Pro Asp Ala Glu
            1620                1625                1630        
Leu Arg Ala Thr Leu Gln Trp Ile Ala Ala Ser Glu Leu Gly Ile Pro
        1635                1640                1645            
Thr Ile Tyr Phe Lys Lys Ser Gln Glu Asn Arg Ile Glu Lys Phe Leu
    1650                1655                1660                
Asp Val Val Gln Leu Val His Arg Lys Ser Trp Lys Val Gly Asp Ile
1665                1670                1675                1680
Phe His Ala Val Val Gln Tyr Cys Lys Met His Glu Glu Gln Lys Asp
                1685                1690                1695    
Gly Arg Leu Ser Leu Phe Asp Trp Leu Leu Glu Leu Gly
            1700                1705                


<210> 6846
<211> 376
<212> PRT
<213> Homo sapiens

<400> 6846
Met Glu Ser Tyr Asp Val Ile Ala Asn Gln Pro Val Val Ile Asp Asn
 1               5                  10                  15      
Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys
            20                  25                  30          
Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Val Arg Val Met
        35                  40                  45              
Ala Gly Ala Leu Glu Gly Asp Ile Phe Ile Gly Pro Lys Ala Glu Glu
    50                  55                  60                  
His Arg Gly Leu Leu Ser Ile Arg Tyr Pro Met Glu His Gly Ile Val
65                  70                  75                  80  
Lys Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys
                85                  90                  95      
Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu
            100                 105                 110         
Ala Pro Leu Asn Pro Arg Lys Asn Arg Glu Arg Ala Ala Glu Val Phe
        115                 120                 125             
Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val
    130                 135                 140                 
Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser
145                 150                 155                 160 
Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met
                165                 170                 175     
Pro His Ser Ile Met Arg Ile Asp Ile Ala Gly Arg Asp Val Ser Arg
            180                 185                 190         
Phe Leu Arg Leu Tyr Leu Arg Lys Glu Gly Tyr Asp Phe His Ser Ser
        195                 200                 205             
Ser Glu Phe Glu Ile Val Lys Ala Ile Lys Glu Arg Ala Cys Tyr Leu
    210                 215                 220                 
Ser Ile Asn Pro Gln Lys Asp Glu Thr Leu Glu Thr Glu Lys Ala Gln
225                 230                 235                 240 
Tyr Tyr Leu Pro Asp Gly Ser Thr Ile Glu Ile Gly Pro Ser Arg Phe
                245                 250                 255     
Arg Ala Pro Glu Leu Leu Phe Arg Pro Asp Leu Ile Gly Glu Glu Ser
            260                 265                 270         
Glu Gly Ile His Glu Val Leu Val Phe Ala Ile Gln Lys Ser Asp Met
        275                 280                 285             
Asp Leu Arg Arg Thr Leu Phe Ser Asn Ile Val Leu Ser Gly Gly Ser
    290                 295                 300                 
Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys
305                 310                 315                 320 
Leu Ala Pro Lys Asp Val Lys Ile Arg Ile Ser Ala Pro Gln Glu Arg
                325                 330                 335     
Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr
            340                 345                 350         
Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ala
        355                 360                 365             
Arg Ser Ile His Arg Lys Thr Phe
    370                 375     


<210> 6847
<211> 1298
<212> PRT
<213> Homo sapiens

<400> 6847
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15      
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30          
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45              
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60                  
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80  
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95      
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110         
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125             
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140                 
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160 
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175     
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190         
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205             
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220                 
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240 
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255     
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270         
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285             
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300                 
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320 
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335     
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350         
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365             
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380                 
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400 
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415     
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430         
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445             
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460                 
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480 
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495     
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510         
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525             
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540                 
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560 
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575     
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590         
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605             
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620                 
Cys Ile Gly Ser Ser Ile Glu Asp Cys Ile Gly Leu Met Asp Arg Thr
625                 630                 635                 640 
Pro Leu Ile Ala Ala Gly Val Ile Gly Gly Leu Phe Ile Leu Val Ile
                645                 650                 655     
Val Gly Leu Thr Phe Ala Val Tyr Val Arg Arg Lys Ser Ile Lys Lys
            660                 665                 670         
Lys Arg Ala Leu Arg Arg Phe Leu Glu Thr Glu Leu Val Glu Pro Leu
        675                 680                 685             
Thr Pro Ser Gly Thr Ala Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys
    690                 695                 700                 
Glu Thr Glu Leu Lys Arg Val Lys Val Leu Gly Ser Gly Ala Phe Gly
705                 710                 715                 720 
Thr Val Tyr Lys Gly Ile Trp Val Pro Glu Gly Glu Thr Val Lys Ile
                725                 730                 735     
Pro Val Ala Ile Lys Ile Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn
            740                 745                 750         
Val Glu Phe Met Asp Glu Ala Leu Ile Met Ala Ser Met Asp His Pro
        755                 760                 765             
His Leu Val Arg Leu Leu Gly Val Cys Leu Ser Pro Thr Ile Gln Leu
    770                 775                 780                 
Val Thr Gln Leu Met Pro His Gly Cys Leu Leu Glu Tyr Val His Glu
785                 790                 795                 800 
His Lys Asp Asn Ile Gly Ser Gln Leu Leu Leu Asn Trp Cys Val Gln
                805                 810                 815     
Ile Ala Lys Gly Met Met Tyr Leu Glu Glu Arg Arg Leu Val His Arg
            820                 825                 830         
Asp Leu Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys
        835                 840                 845             
Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu
    850                 855                 860                 
Tyr Asn Ala Asp Gly Gly Lys Met Pro Ile Lys Trp Met Ala Leu Glu
865                 870                 875                 880 
Cys Ile His Tyr Arg Lys Phe Thr His Gln Ser Asp Val Trp Ser Tyr
                885                 890                 895     
Gly Val Thr Ile Trp Glu Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp
            900                 905                 910         
Gly Ile Pro Thr Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg
        915                 920                 925             
Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Val Met Val
    930                 935                 940                 
Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu
945                 950                 955                 960 
Ala Ala Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Tyr Leu Val
                965                 970                 975     
Ile Gln Gly Asp Asp Arg Met Lys Leu Pro Ser Pro Asn Asp Ser Lys
            980                 985                 990         
Phe Phe Gln Asn Leu Leu Asp Glu Glu Asp Leu Glu Asp Met Met Asp
        995                 1000                1005            
Ala Glu Glu Tyr Leu Val Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile
    1010                1015                1020                
Tyr Thr Ser Arg Ala Arg Ile Asp Ser Asn Arg Ser Glu Ile Gly His
1025                1030                1035                1040
Ser Pro Pro Pro Ala Tyr Thr Pro Met Ser Gly Asn Gln Phe Val Tyr
                1045                1050                1055    
Arg Asp Gly Gly Phe Ala Ala Glu Gln Gly Val Ser Val Pro Tyr Arg
            1060                1065                1070        
Ala Pro Thr Ser Thr Ile Pro Glu Ala Pro Val Ala Gln Gly Ala Thr
        1075                1080                1085            
Ala Glu Ile Phe Asp Asp Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro
    1090                1095                1100                
Val Ala Pro His Val Gln Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala
1105                1110                1115                1120
Asp Pro Thr Val Phe Ala Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp
                1125                1130                1135    
Glu Glu Gly Tyr Met Thr Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr
            1140                1145                1150        
Leu Asn Pro Val Glu Glu Asn Pro Phe Val Ser Arg Arg Lys Asn Gly
        1155                1160                1165            
Asp Leu Gln Ala Leu Asp Asn Pro Glu Tyr His Asn Ala Ser Asn Gly
    1170                1175                1180                
Pro Pro Lys Ala Glu Asp Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn
1185                1190                1195                1200
Thr Phe Ala Asn Thr Leu Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile
                1205                1210                1215    
Leu Ser Met Pro Glu Lys Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr
            1220                1225                1230        
Trp Asn His Ser Leu Pro Pro Arg Ser Thr Leu Gln His Pro Asp Tyr
        1235                1240                1245            
Leu Gln Glu Tyr Ser Thr Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile
    1250                1255                1260                
Arg Pro Ile Val Ala Glu Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu
1265                1270                1275                1280
Lys Pro Gly Thr Val Leu Pro Pro Pro Pro Tyr Arg His Arg Asn Thr
                1285                1290                1295    
Val Val
        


<210> 6848
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 6848
Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala
 1               5                  10                  15      
Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr
            20                  25                  30          
Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala
        35                  40                  45              
Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60                  
Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val
65                  70                  75                  80  
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr
                85                  90                  95      
Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu
            100                 105                 110         
Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn
        115                 120                 125             
Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn
    130                 135                 140                 
Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr
145                 150                 155                 160 
Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr
                165                 170                 175     
Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser
            180                 185                 190         
Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu
        195                 200                 205             
Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro
    210                 215                 220                 
Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly
225                 230                 235                 240 
Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly
                245                 250                 255     
Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr
            260                 265                 270         
Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe
        275                 280                 285             
Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys
    290                 295                 300                 
Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile
305                 310                 315                 320 
Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly
                325                 330                 335     
Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn
            340                 345                 350         
Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe
        355                 360                 365             
Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile
    370                 375                 380                 
Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly
385                 390                 395                 400 
Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val
                405                 410                 415     
Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu
            420                 425                 430         
Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln
        435                 440                 445             
Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser
    450                 455                 460                 
Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr
465                 470                 475                 480 
Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys
                485                 490                 495     
Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys
            500                 505                 510         
Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg
        515                 520                 525             
Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg
    530                 535                 540                 
Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu
545                 550                 555                 560 
Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn
                565                 570                 575     
Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys
            580                 585                 590         
Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala
        595                 600                 605             
Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly
    610                 615                 620                 
Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly
625                 630                 635                 640 
His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly
                645                 650                 655     
Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala
            660                 665                 670         
Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg
        675                 680                 685             
Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala
    690                 695                 700                 
Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg
705                 710                 715                 720 
Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
                725                 730                 735     
Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile
            740                 745                 750         
Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu
        755                 760                 765             
Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu
    770                 775                 780                 
Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro
785                 790                 795                 800 
His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly
                805                 810                 815     
Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met
            820                 825                 830         
Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
        835                 840                 845             
Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
    850                 855                 860                 
Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly
865                 870                 875                 880 
Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys
                885                 890                 895     
Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu
            900                 905                 910         
Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu
        915                 920                 925             
Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
    930                 935                 940                 
Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp
945                 950                 955                 960 
Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg
                965                 970                 975     
Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg
            980                 985                 990         
Met Lys Leu Pro Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu
        995                 1000                1005            
Asp Glu Glu Asp Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val
    1010                1015                1020                
Pro Gln Ala Phe Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg
1025                1030                1035                1040
Ile Asp Ser Asn Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr
                1045                1050                1055    
Thr Pro Met Ser Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala
            1060                1065                1070        
Ala Glu Gln Gly Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile
        1075                1080                1085            
Pro Glu Ala Pro Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp
    1090                1095                1100                
Ser Cys Cys Asn Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln
1105                1110                1115                1120
Glu Asp Ser Ser Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala
                1125                1130                1135    
Pro Glu Arg Ser Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr
            1140                1145                1150        
Pro Met Arg Asp Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu
        1155                1160                1165            
Asn Pro Phe Val Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp
    1170                1175                1180                
Asn Pro Glu Tyr His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp
1185                1190                1195                1200
Glu Tyr Val Asn Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu
                1205                1210                1215    
Gly Lys Ala Glu Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys
            1220                1225                1230        
Ala Lys Lys Ala Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro
        1235                1240                1245            
Pro Arg Ser Thr Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr
    1250                1255                1260                
Lys Tyr Phe Tyr Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu
1265                1270                1275                1280
Asn Pro Glu Tyr Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu
                1285                1290                1295    
Pro Pro Pro Pro Tyr Arg His Arg Asn Thr Val Val
            1300                1305            


<210> 6849
<211> 3859
<212> PRT
<213> Homo sapiens

<400> 6849
Met Ala Glu Gly Gly Glu Gly Gly Glu Asp Glu Ile Gln Phe Leu Arg
 1               5                  10                  15      
Thr Glu Asp Glu Val Val Leu Gln Cys Ile Ala Thr Ile His Lys Glu
            20                  25                  30          
Gln Arg Lys Phe Cys Leu Ala Ala Glu Gly Leu Gly Asn Arg Leu Cys
        35                  40                  45              
Phe Leu Glu Pro Thr Ser Glu Ala Lys Tyr Ile Pro Pro Asp Leu Cys
    50                  55                  60                  
Val Cys Asn Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln
65                  70                  75                  80  
Glu Met Leu Ala Asn Thr Gly Glu Asn Gly Gly Glu Gly Ala Ala Gln
                85                  90                  95      
Gly Gly Gly His Arg Thr Leu Leu Tyr Gly His Ala Val Leu Leu Arg
            100                 105                 110         
His Ser Phe Ser Gly Met Tyr Leu Thr Cys Leu Thr Thr Ser Arg Ser
        115                 120                 125             
Gln Thr Asp Lys Leu Ala Phe Asp Val Gly Leu Arg Glu His Ala Thr
    130                 135                 140                 
Gly Glu Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser
145                 150                 155                 160 
Glu Gly Glu Lys Val Arg Ile Gly Asp Asp Leu Ile Leu Val Ser Val
                165                 170                 175     
Ser Ser Glu Arg Tyr Leu His Leu Ser Val Ser Asn Gly Asn Ile Gln
            180                 185                 190         
Val Asp Ala Ser Phe Met Gln Thr Leu Trp Asn Val His Pro Thr Cys
        195                 200                 205             
Ser Gly Ser Ser Ile Glu Glu Gly Tyr Leu Leu Gly Gly His Val Val
    210                 215                 220                 
Arg Leu Phe His Gly His Asp Glu Cys Leu Thr Ile Pro Ser Thr Asp
225                 230                 235                 240 
Gln Asn Asp Ser Gln His Arg Arg Ile Phe Tyr Glu Ala Gly Gly Ala
                245                 250                 255     
Gly Thr Arg Ala Ser Ser Leu Trp Arg Val Glu Pro Leu Arg Ile Ser
            260                 265                 270         
Trp Ser Gly Ser Asn Ile Arg Trp Gly Gln Ala Phe Arg Leu Arg His
        275                 280                 285             
Leu Thr Thr Gly His Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Ile
    290                 295                 300                 
Leu Gln Asp Arg Ala Lys Ser Asp Thr Lys Ser Thr Ala Phe Ser Phe
305                 310                 315                 320 
Arg Ala Ser Lys Glu Leu Lys Glu Lys Leu Asp Ser Ser His Lys Arg
                325                 330                 335     
Asp Ile Glu Gly Met Gly Val Pro Glu Ile Lys Tyr Gly Asp Ser Val
            340                 345                 350         
Cys Phe Val Gln His Ile Ala Ser Gly Leu Trp Val Thr Tyr Lys Ala
        355                 360                 365             
Gln Asp Ala Lys Thr Ser Arg Leu Gly Pro Leu Lys Arg Lys Val Ile
    370                 375                 380                 
Leu His Gln Glu Gly His Met Asp Asp Gly Leu Thr Leu Gln Arg Cys
385                 390                 395                 400 
Gln Arg Glu Glu Ser Gln Ala Ala Arg Ile Ile Arg Asn Thr Thr Ala
                405                 410                 415     
Leu Phe Ser Gln Phe Val Ser Gly Asn Asn Arg Thr Ala Ala Pro Ile
            420                 425                 430         
Thr Leu Pro Ile Glu Glu Val Leu Gln Thr Leu Gln Asp Leu Ile Ala
        435                 440                 445             
Tyr Phe Gln Pro Pro Glu Glu Glu Met Arg His Glu Asp Lys Gln Asn
    450                 455                 460                 
Lys Leu Arg Ser Leu Lys Asn Arg Gln Asn Leu Phe Lys Glu Glu Gly
465                 470                 475                 480 
Met Leu Ala Leu Val Leu Asn Cys Ile Asp Arg Leu Asn Ile Tyr Asn
                485                 490                 495     
Ser Val Ala His Phe Ala Gly Ile Ala Arg Glu Glu Ser Gly Met Ala
            500                 505                 510         
Trp Lys Glu Ile Leu Asn Leu Leu Tyr Lys Leu Leu Ala Ala Leu Ile
        515                 520                 525             
Arg Gly Asn Arg Asn Asn Cys Ala Gln Phe Ser Asn Asn Leu Asp Trp
    530                 535                 540                 
Leu Ile Ser Lys Leu Asp Arg Leu Glu Ser Ser Ser Gly Ile Leu Glu
545                 550                 555                 560 
Val Leu His Cys Ile Leu Thr Glu Ser Pro Glu Ala Leu Asn Leu Ile
                565                 570                 575     
Ala Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly
            580                 585                 590         
Arg Asn His Lys Val Leu Asp Ile Leu Cys Ser Leu Cys Leu Cys Asn
        595                 600                 605             
Gly Val Ala Val Arg Ala Asn Gln Asn Leu Ile Cys Asp Asn Leu Leu
    610                 615                 620                 
Pro Arg Arg Asn Leu Leu Leu Gln Thr Arg Leu Ile Asn Asp Val Thr
625                 630                 635                 640 
Ser Ile Arg Pro Asn Ile Phe Leu Gly Val Ala Glu Gly Ser Ala Gln
                645                 650                 655     
Tyr Lys Lys Trp Tyr Phe Glu Leu Ile Ile Asp Gln Val Asp Pro Phe
            660                 665                 670         
Leu Thr Ala Glu Pro Thr His Leu Arg Val Gly Trp Ala Ser Ser Ser
        675                 680                 685             
Gly Tyr Ala Pro Cys Pro Gly Gly Gly Glu Gly Trp Gly Gly Asn Gly
    690                 695                 700                 
Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu Trp
705                 710                 715                 720 
Ser Gly Arg Ile Pro Arg Ala Val Ala Ser Val Asn Gln His Leu Leu
                725                 730                 735     
Arg Ser Asp Asp Val Val Ser Cys Cys Leu Asp Leu Gly Val Pro Ser
            740                 745                 750         
Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn
        755                 760                 765             
Phe Asn Thr Asp Gly Leu Phe Phe Pro Val Met Ser Phe Ser Ala Gly
    770                 775                 780                 
Val Lys Val Arg Phe Leu Met Gly Gly Arg His Gly Glu Phe Lys Phe
785                 790                 795                 800 
Leu Pro Pro Ser Gly Tyr Ala Pro Cys Tyr Glu Ala Leu Leu Pro Lys
                805                 810                 815     
Glu Lys Met Arg Leu Glu Pro Val Lys Glu Tyr Lys Arg Asp Ala Asp
            820                 825                 830         
Gly Ile Arg Asp Leu Leu Gly Thr Thr Gln Phe Leu Ser Gln Ala Ser
        835                 840                 845             
Phe Ile Pro Cys Pro Val Asp Thr Ser Gln Val Ile Leu Pro Pro His
    850                 855                 860                 
Leu Glu Lys Ile Arg Asp Arg Leu Ala Glu Asn Ile His Glu Leu Trp
865                 870                 875                 880 
Gly Met Asn Lys Ile Glu Leu Gly Trp Thr Phe Gly Lys Ile Arg Asp
                885                 890                 895     
Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro
            900                 905                 910         
Glu Thr Glu Lys Asn Tyr Asn Leu Gln Met Ser Thr Glu Thr Leu Lys
        915                 920                 925             
Thr Leu Leu Ala Leu Gly Cys His Ile Ala His Val Asn Pro Ala Ala
    930                 935                 940                 
Glu Glu Asp Leu Lys Lys Val Lys Leu Pro Lys Asn Tyr Met Met Ser
945                 950                 955                 960 
Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser Asp Val Lys Leu Leu
                965                 970                 975     
Pro Pro Gln Glu Ile Leu Val Asp Lys Leu Ala Glu Asn Ala His Asn
            980                 985                 990         
Val Trp Ala Lys Asp Arg Ile Lys Gln Gly Trp Thr Tyr Gly Ile Gln
        995                 1000                1005            
Gln Asp Leu Lys Asn Lys Arg Asn Pro Arg Leu Val Pro Tyr Ala Leu
    1010                1015                1020                
Leu Asp Glu Arg Thr Lys Lys Ser Asn Arg Asp Ser Leu Arg Glu Ala
1025                1030                1035                1040
Val Arg Thr Phe Val Gly Tyr Gly Tyr Asn Ile Glu Pro Ser Asp Gln
                1045                1050                1055    
Glu Leu Ala Asp Ser Ala Val Glu Lys Val Ser Ile Asp Lys Ile Arg
            1060                1065                1070        
Phe Phe Arg Val Glu Arg Ser Tyr Ala Val Arg Ser Gly Lys Trp Tyr
        1075                1080                1085            
Phe Glu Phe Glu Val Val Thr Gly Gly Asp Met Arg Val Gly Trp Ala
    1090                1095                1100                
Arg Pro Gly Cys Arg Pro Asp Val Glu Leu Gly Ala Asp Asp Gln Ala
1105                1110                1115                1120
Phe Val Phe Glu Gly Asn Arg Gly Gln Arg Trp His Gln Gly Ser Gly
                1125                1130                1135    
Tyr Phe Gly Arg Thr Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile
            1140                1145                1150        
Asn Leu Asp Asp Ala Ser Met Ile Phe Thr Leu Asn Gly Glu Leu Leu
        1155                1160                1165            
Ile Thr Asn Lys Gly Ser Glu Leu Ala Phe Ala Asp Tyr Glu Ile Glu
    1170                1175                1180                
Asn Gly Phe Val Pro Ile Cys Cys Leu Gly Leu Ser Gln Ile Gly Arg
1185                1190                1195                1200
Met Asn Leu Gly Thr Asp Ala Ser Thr Phe Lys Phe Tyr Thr Met Cys
                1205                1210                1215    
Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Val Asn Met Asn Arg Asp
            1220                1225                1230        
Val Ala Met Trp Phe Ser Lys Arg Leu Pro Thr Phe Val Asn Val Pro
        1235                1240                1245            
Lys Asp His Pro His Ile Glu Val Met Arg Ile Asp Gly Thr Met Asp
    1250                1255                1260                
Ser Pro Pro Cys Leu Lys Val Thr His Lys Thr Phe Gly Thr Gln Asn
1265                1270                1275                1280
Ser Asn Ala Asp Met Ile Tyr Cys Arg Leu Ser Met Pro Val Glu Cys
                1285                1290                1295    
His Ser Ser Phe Ser His Ser Pro Cys Leu Asp Ser Glu Ala Phe Gln
            1300                1305                1310        
Lys Arg Lys Gln Met Gln Glu Ile Leu Ser His Thr Thr Thr Gln Cys
        1315                1320                1325            
Tyr Tyr Ala Ile Arg Ile Phe Ala Gly Gln Asp Pro Ser Cys Val Trp
    1330                1335                1340                
Val Gly Trp Val Thr Pro Asp Tyr His Leu Tyr Ser Glu Lys Phe Asp
1345                1350                1355                1360
Leu Asn Lys Asn Cys Thr Val Thr Val Thr Leu Gly Asp Glu Arg Gly
                1365                1370                1375    
Arg Val His Glu Ser Val Lys Arg Ser Asn Cys Tyr Met Val Trp Gly
            1380                1385                1390        
Gly Asp Ile Val Ala Ser Ser Gln Arg Ser Asn Arg Ser Asn Val Asp
        1395                1400                1405            
Leu Glu Ile Gly Cys Leu Val Asp Leu Ala Met Gly Met Leu Ser Phe
    1410                1415                1420                
Ser Ala Asn Gly Lys Glu Leu Gly Thr Cys Tyr Gln Val Glu Pro Asn
1425                1430                1435                1440
Thr Lys Val Phe Pro Ala Val Phe Leu Gln Pro Thr Ser Thr Ser Leu
                1445                1450                1455    
Phe Gln Phe Glu Leu Gly Lys Leu Lys Asn Ala Met Pro Leu Ser Ala
            1460                1465                1470        
Ala Ile Phe Arg Ser Glu Glu Lys Asn Pro Val Pro Gln Cys Pro Pro
        1475                1480                1485            
Arg Leu Asp Val Gln Thr Ile Gln Pro Val Leu Trp Ser Arg Met Pro
    1490                1495                1500                
Asn Ser Phe Leu Lys Val Glu Thr Glu Arg Val Ser Glu Arg His Gly
1505                1510                1515                1520
Trp Val Val Gln Cys Leu Glu Pro Leu Gln Met Met Ala Leu His Ile
                1525                1530                1535    
Pro Glu Glu Asn Arg Cys Val Asp Ile Leu Glu Leu Cys Glu Gln Glu
            1540                1545                1550        
Asp Leu Met Arg Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val
        1555                1560                1565            
Cys Ala Leu Gly Asn Ser Arg Val Ala Tyr Ala Leu Cys Ser His Val
    1570                1575                1580                
Asp Leu Ser Gln Leu Phe Tyr Ala Ile Asp Asn Lys Tyr Leu Pro Gly
1585                1590                1595                1600
Leu Leu Arg Ser Gly Phe Tyr Asp Leu Leu Ile Ser Ile His Leu Ala
                1605                1610                1615    
Ser Ala Lys Glu Arg Lys Leu Met Met Lys Asn Glu Tyr Ile Ile Pro
            1620                1625                1630        
Ile Thr Ser Thr Thr Arg Asn Ile Cys Leu Phe Pro Asp Glu Ser Lys
        1635                1640                1645            
Arg His Gly Leu Pro Gly Val Gly Leu Arg Thr Cys Leu Lys Pro Gly
    1650                1655                1660                
Phe Arg Phe Ser Thr Pro Cys Phe Val Val Thr Gly Glu Asp His Gln
1665                1670                1675                1680
Lys Gln Ser Pro Glu Ile Pro Leu Glu Ser Leu Arg Thr Lys Ala Leu
                1685                1690                1695    
Ser Met Leu Thr Glu Ala Val Gln Cys Ser Gly Ala His Ile Arg Asp
            1700                1705                1710        
Pro Val Gly Gly Ser Val Glu Phe Gln Phe Val Pro Val Leu Lys Leu
        1715                1720                1725            
Ile Gly Thr Leu Leu Val Met Gly Val Phe Asp Asp Asp Asp Val Arg
    1730                1735                1740                
Gln Ile Leu Leu Leu Ile Asp Pro Ser Val Phe Gly Glu His Ser Ala
1745                1750                1755                1760
Gly Thr Glu Glu Gly Ala Glu Lys Glu Glu Val Thr Gln Val Glu Glu
                1765                1770                1775    
Lys Ala Val Glu Ala Gly Glu Lys Ala Gly Lys Glu Ala Pro Val Lys
            1780                1785                1790        
Gly Leu Leu Gln Thr Arg Leu Pro Glu Ser Val Lys Leu Gln Met Cys
        1795                1800                1805            
Glu Leu Leu Ser Tyr Leu Cys Asp Cys Glu Leu Gln His Arg Val Glu
    1810                1815                1820                
Ala Ile Val Ala Phe Gly Asp Ile Tyr Val Ser Lys Leu Gln Ala Asn
1825                1830                1835                1840
Gln Lys Phe Arg Tyr Asn Glu Leu Met Gln Ala Leu Asn Met Ser Ala
                1845                1850                1855    
Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro Pro Gln Glu
            1860                1865                1870        
Gln Ile Asn Met Leu Leu Asn Phe Gln Leu Gly Glu Asn Cys Pro Cys
        1875                1880                1885            
Pro Glu Glu Ile Arg Glu Glu Leu Tyr Asp Phe His Glu Asp Leu Leu
    1890                1895                1900                
Leu His Cys Gly Val Pro Leu Glu Glu Glu Glu Glu Glu Glu Glu Asp
1905                1910                1915                1920
Thr Ser Trp Thr Gly Lys Leu Cys Ala Leu Val Tyr Lys Ile Lys Gly
                1925                1930                1935    
Pro Pro Lys Pro Glu Lys Glu Gln Pro Thr Glu Glu Glu Glu Arg Cys
            1940                1945                1950        
Pro Thr Thr Leu Lys Glu Leu Ile Ser Gln Thr Met Ile Cys Trp Ala
        1955                1960                1965            
Gln Glu Asp Gln Ile Gln Asp Ser Glu Leu Val Arg Met Met Phe Asn
    1970                1975                1980                
Leu Leu Arg Arg Gln Tyr Asp Ser Ile Gly Glu Leu Leu Gln Ala Leu
1985                1990                1995                2000
Arg Lys Thr Tyr Thr Ile Ser His Thr Ser Val Ser Asp Thr Ile Asn
                2005                2010                2015    
Leu Leu Ala Ala Leu Gly Gln Ile Arg Ser Leu Leu Ser Val Arg Met
            2020                2025                2030        
Gly Lys Glu Glu Glu Leu Leu Met Ile Asn Gly Leu Gly Asp Ile Met
        2035                2040                2045            
Asn Asn Lys Val Phe Tyr Gln His Pro Asn Leu Met Arg Val Leu Gly
    2050                2055                2060                
Met His Glu Thr Val Met Glu Val Met Val Asn Val Leu Gly Thr Glu
2065                2070                2075                2080
Lys Ser Gln Ile Ala Phe Pro Lys Met Val Ala Ser Cys Cys Arg Phe
                2085                2090                2095    
Leu Cys Tyr Phe Cys Arg Ile Ser Arg Gln Asn Gln Lys Ala Met Phe
            2100                2105                2110        
Glu His Leu Ser Tyr Leu Leu Glu Asn Ser Ser Val Gly Leu Ala Ser
        2115                2120                2125            
Pro Ser Met Arg Gly Ser Thr Pro Leu Asp Val Ala Ala Ser Ser Val
    2130                2135                2140                
Met Asp Asn Asn Glu Leu Ala Leu Ser Leu Glu Glu Pro Asp Leu Glu
2145                2150                2155                2160
Lys Val Val Thr Tyr Leu Ala Gly Cys Gly Leu Gln Ser Cys Pro Met
                2165                2170                2175    
Leu Leu Ala Lys Gly Tyr Pro Asp Val Gly Trp Asn Pro Ile Glu Gly
            2180                2185                2190        
Glu Arg Tyr Leu Ser Phe Leu Arg Phe Ala Val Phe Val Asn Ser Glu
        2195                2200                2205            
Ser Val Glu Glu Asn Ala Ser Val Val Val Lys Leu Leu Ile Arg Arg
    2210                2215                2220                
Pro Glu Cys Phe Gly Pro Ala Leu Arg Gly Glu Gly Gly Asn Gly Leu
2225                2230                2235                2240
Leu Ala Ala Met Gln Gly Ala Ile Lys Ile Ser Glu Asn Pro Ala Leu
                2245                2250                2255    
Asp Leu Pro Ser Gln Gly Tyr Lys Arg Glu Val Ser Thr Glu Asp Asp
            2260                2265                2270        
Glu Glu Glu Glu Glu Ile Val His Met Gly Asn Ala Ile Met Ser Phe
        2275                2280                2285            
Tyr Ser Ala Leu Ile Asp Leu Leu Gly Arg Cys Ala Pro Glu Met His
    2290                2295                2300                
Leu Ile Gln Thr Gly Lys Gly Glu Ala Ile Arg Ile Arg Ser Ile Leu
2305                2310                2315                2320
Arg Ser Leu Val Pro Thr Glu Asp Leu Val Gly Ile Ile Ser Ile Pro
                2325                2330                2335    
Leu Lys Leu Pro Ser Leu Asn Lys Asp Gly Ser Val Ser Glu Pro Asp
            2340                2345                2350        
Met Ala Ala Asn Phe Cys Pro Asp His Lys Ala Pro Met Val Leu Phe
        2355                2360                2365            
Leu Asp Arg Val Tyr Gly Ile Lys Asp Gln Thr Phe Leu Leu His Leu
    2370                2375                2380                
Leu Glu Val Gly Phe Leu Pro Asp Leu Arg Ala Ser Ala Ser Leu Asp
2385                2390                2395                2400
Thr Val Ser Leu Ser Thr Thr Glu Ala Ala Leu Ala Leu Asn Arg Tyr
                2405                2410                2415    
Ile Cys Ser Ala Val Leu Pro Leu Leu Thr Arg Cys Ala Pro Leu Phe
            2420                2425                2430        
Ala Gly Thr Glu His Cys Thr Ser Leu Ile Asp Ser Thr Leu Gln Thr
        2435                2440                2445            
Ile Tyr Arg Leu Ser Lys Gly Arg Ser Leu Thr Lys Ala Gln Arg Asp
    2450                2455                2460                
Thr Ile Glu Glu Cys Leu Leu Ala Ile Cys Asn His Leu Arg Pro Ser
2465                2470                2475                2480
Met Leu Gln Gln Leu Leu Arg Arg Leu Val Phe Asp Val Pro Gln Leu
                2485                2490                2495    
Asn Glu Tyr Cys Lys Met Pro Leu Lys Leu Leu Thr Asn His Tyr Glu
            2500                2505                2510        
Gln Cys Trp Lys Tyr Tyr Cys Leu Pro Ser Gly Trp Gly Ser Tyr Gly
        2515                2520                2525            
Leu Ala Val Glu Glu Glu Leu His Leu Thr Glu Lys Leu Phe Trp Gly
    2530                2535                2540                
Ile Phe Asp Ser Leu Ser His Lys Lys Tyr Asp Pro Asp Leu Phe Arg
2545                2550                2555                2560
Met Ala Leu Pro Cys Leu Ser Ala Ile Ala Gly Ala Leu Pro Pro Asp
                2565                2570                2575    
Tyr Leu Asp Thr Arg Ile Thr Ala Thr Leu Glu Lys Gln Ile Ser Val
            2580                2585                2590        
Asp Ala Asp Gly Asn Phe Asp Pro Lys Pro Ile Asn Thr Met Asn Phe
        2595                2600                2605            
Ser Leu Pro Glu Lys Leu Glu Tyr Ile Val Thr Lys Tyr Ala Glu His
    2610                2615                2620                
Ser His Asp Lys Trp Ala Cys Asp Lys Ser Gln Ser Gly Trp Lys Tyr
2625                2630                2635                2640
Gly Ile Ser Leu Asp Glu Asn Val Lys Thr His Pro Leu Ile Arg Pro
                2645                2650                2655    
Phe Lys Thr Leu Thr Glu Lys Glu Lys Glu Ile Tyr Arg Trp Pro Ala
            2660                2665                2670        
Arg Glu Ser Leu Lys Thr Met Leu Ala Val Gly Trp Thr Val Glu Arg
        2675                2680                2685            
Thr Lys Glu Gly Glu Ala Leu Val Gln Gln Arg Glu Asn Glu Lys Leu
    2690                2695                2700                
Arg Ser Val Ser Gln Ala Asn Gln Gly Asn Ser Tyr Ser Pro Ala Pro
2705                2710                2715                2720
Leu Asp Leu Ser Asn Val Val Leu Ser Arg Glu Leu Gln Gly Met Val
                2725                2730                2735    
Glu Val Val Ala Glu Asn Tyr His Asn Ile Trp Ala Lys Lys Lys Lys
            2740                2745                2750        
Leu Glu Leu Glu Ser Lys Gly Gly Gly Ser His Pro Leu Leu Val Pro
        2755                2760                2765            
Tyr Asp Thr Leu Thr Ala Lys Glu Lys Phe Lys Asp Arg Glu Lys Ala
    2770                2775                2780                
Gln Asp Leu Phe Lys Phe Leu Gln Val Asn Gly Ile Ile Val Ser Arg
2785                2790                2795                2800
Gly Met Lys Asp Met Glu Leu Asp Ala Ser Ser Met Glu Lys Arg Phe
                2805                2810                2815    
Ala Tyr Lys Phe Leu Lys Lys Ile Leu Lys Tyr Val Asp Ser Ala Gln
            2820                2825                2830        
Glu Phe Ile Ala His Leu Glu Ala Ile Val Ser Ser Gly Lys Thr Glu
        2835                2840                2845            
Lys Ser Pro Arg Asp Gln Glu Ile Lys Phe Phe Ala Lys Val Leu Leu
    2850                2855                2860                
Pro Leu Val Asp Gln Tyr Phe Thr Ser His Cys Leu Tyr Phe Leu Ser
2865                2870                2875                2880
Ser Pro Leu Lys Pro Leu Ser Ser Ser Gly Tyr Ala Ser His Lys Glu
                2885                2890                2895    
Lys Glu Met Val Ala Gly Leu Phe Cys Lys Leu Ala Ala Leu Val Arg
            2900                2905                2910        
His Arg Ile Ser Leu Phe Gly Ser Asp Ser Thr Thr Met Val Ser Cys
        2915                2920                2925            
Leu His Ile Leu Ala Gln Thr Leu Asp Thr Arg Thr Val Met Lys Ser
    2930                2935                2940                
Gly Ser Glu Leu Val Lys Ala Gly Leu Arg Ala Phe Phe Glu Asn Ala
2945                2950                2955                2960
Ala Glu Asp Leu Glu Lys Thr Ser Glu Asn Leu Lys Leu Gly Lys Phe
                2965                2970                2975    
Thr His Ser Arg Thr Gln Ile Lys Gly Val Ser Gln Asn Ile Asn Tyr
            2980                2985                2990        
Thr Thr Val Ala Leu Leu Pro Ile Leu Thr Ser Ile Phe Glu His Val
        2995                3000                3005            
Thr Gln His Gln Phe Gly Met Asp Leu Leu Leu Gly Asp Val Gln Ile
    3010                3015                3020                
Ser Cys Tyr His Ile Leu Cys Ser Leu Tyr Ser Leu Gly Thr Gly Lys
3025                3030                3035                3040
Asn Ile Tyr Val Glu Arg Gln Arg Pro Ala Leu Gly Glu Cys Leu Ala
                3045                3050                3055    
Ser Leu Ala Ala Ala Ile Pro Val Ala Phe Leu Glu Pro Thr Leu Asn
            3060                3065                3070        
Arg Tyr Asn Pro Leu Ser Val Phe Asn Thr Lys Thr Pro Arg Glu Arg
        3075                3080                3085            
Ser Ile Leu Gly Met Pro Asp Thr Val Glu Asp Met Cys Pro Asp Ile
    3090                3095                3100                
Pro Gln Leu Glu Gly Leu Met Lys Glu Ile Asn Asp Leu Ala Glu Ser
3105                3110                3115                3120
Gly Ala Arg Tyr Thr Glu Met Pro His Val Ile Glu Val Ile Leu Pro
                3125                3130                3135    
Met Leu Cys Asn Tyr Leu Ser Tyr Trp Trp Glu Arg Gly Pro Glu Asn
            3140                3145                3150        
Leu Pro Pro Ser Thr Gly Pro Cys Cys Thr Lys Val Thr Ser Glu His
        3155                3160                3165            
Leu Ser Leu Ile Leu Gly Asn Ile Leu Lys Ile Ile Asn Asn Asn Leu
    3170                3175                3180                
Gly Ile Asp Glu Ala Ser Trp Met Lys Arg Ile Ala Val Tyr Ala Gln
3185                3190                3195                3200
Pro Ile Ile Ser Lys Ala Arg Pro Asp Leu Leu Arg Ser His Phe Ile
                3205                3210                3215    
Pro Thr Leu Glu Lys Leu Lys Lys Lys Ala Val Lys Thr Val Gln Glu
            3220                3225                3230        
Glu Glu Gln Leu Lys Ala Asp Gly Lys Gly Asp Thr Gln Glu Ala Glu
        3235                3240                3245            
Leu Leu Ile Leu Asp Glu Phe Ala Val Leu Cys Arg Asp Leu Tyr Ala
    3250                3255                3260                
Phe Tyr Pro Met Leu Ile Arg Tyr Val Asp Asn Asn Arg Ser Asn Trp
3265                3270                3275                3280
Leu Lys Ser Pro Asp Ala Asp Ser Asp Gln Leu Phe Arg Met Val Ala
                3285                3290                3295    
Glu Val Phe Ile Leu Trp Cys Lys Ser His Asn Phe Lys Arg Glu Glu
            3300                3305                3310        
Gln Asn Phe Val Ile Gln Asn Glu Ile Asn Asn Leu Ala Phe Leu Thr
        3315                3320                3325            
Gly Asp Ser Lys Ser Lys Met Ser Lys Ala Met Gln Val Lys Ser Gly
    3330                3335                3340                
Gly Gln Asp Gln Glu Arg Lys Lys Thr Lys Arg Arg Gly Asp Leu Tyr
3345                3350                3355                3360
Ser Ile Gln Thr Ser Leu Ile Val Ala Ala Leu Lys Lys Met Leu Pro
                3365                3370                3375    
Ile Gly Leu Asn Met Cys Thr Pro Gly Asp Gln Glu Leu Ile Ser Leu
            3380                3385                3390        
Ala Lys Ser Arg Tyr Ser His Arg Asp Thr Asp Glu Glu Val Arg Glu
        3395                3400                3405            
His Leu Arg Asn Asn Leu His Leu Gln Glu Lys Ser Asp Asp Pro Ala
    3410                3415                3420                
Val Lys Trp Gln Leu Asn Leu Tyr Lys Asp Val Leu Lys Ser Glu Glu
3425                3430                3435                3440
Pro Phe Asn Pro Glu Lys Thr Val Glu Arg Val Gln Arg Ile Ser Ala
                3445                3450                3455    
Ala Val Phe His Leu Glu Gln Val Glu Gln Pro Leu Arg Ser Lys Lys
            3460                3465                3470        
Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Lys Arg Ala Val Val
        3475                3480                3485            
Ala Cys Phe Arg Met Ala Pro Leu Tyr Asn Leu Pro Arg His Arg Ser
    3490                3495                3500                
Ile Asn Leu Phe Leu His Gly Tyr Gln Arg Phe Trp Ile Glu Thr Glu
3505                3510                3515                3520
Glu Tyr Ser Phe Glu Glu Lys Leu Val Gln Asp Leu Ala Lys Ser Pro
                3525                3530                3535    
Lys Val Glu Glu Glu Glu Glu Glu Glu Thr Glu Lys Gln Pro Asp Pro
            3540                3545                3550        
Leu His Gln Ile Ile Leu Tyr Phe Ser Arg Asn Ala Leu Thr Glu Arg
        3555                3560                3565            
Ser Lys Leu Glu Asp Asp Pro Leu Tyr Thr Ser Tyr Ser Ser Met Met
    3570                3575                3580                
Ala Lys Ser Cys Gln Ser Gly Glu Asp Glu Glu Glu Asp Glu Asp Lys
3585                3590                3595                3600
Glu Lys Thr Phe Glu Glu Lys Glu Met Glu Lys Gln Lys Thr Leu Tyr
                3605                3610                3615    
Gln Gln Ala Arg Leu His Glu Arg Gly Ala Ala Glu Met Val Leu Gln
            3620                3625                3630        
Met Ile Ser Ala Ser Lys Gly Glu Met Ser Pro Met Val Val Glu Thr
        3635                3640                3645            
Leu Lys Leu Gly Ile Ala Ile Leu Asn Gly Gly Asn Ala Gly Val Gln
    3650                3655                3660                
Gln Lys Met Leu Asp Tyr Leu Lys Glu Lys Lys Asp Ala Gly Phe Phe
3665                3670                3675                3680
Gln Ser Leu Ser Gly Leu Met Gln Ser Cys Ser Val Leu Asp Leu Asn
                3685                3690                3695    
Ala Phe Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly Met Val Thr Glu
            3700                3705                3710        
Glu Gly Thr Leu Ile Val Arg Glu Arg Gly Glu Lys Val Leu Gln Asn
        3715                3720                3725            
Asp Glu Phe Thr Arg Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu
    3730                3735                3740                
Gly His Asn Ser Asp Phe Gln Asn Phe Leu Arg Thr Gln Met Gly Asn
3745                3750                3755                3760
Thr Thr Thr Val Asn Val Ile Ile Ser Thr Val Asp Tyr Leu Leu Arg
                3765                3770                3775    
Leu Gln Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp
            3780                3785                3790        
Ile Ile Asp Glu Ser Gly Gln His Asn Phe Ser Lys Ala Leu Ala Val
        3795                3800                3805            
Thr Lys Gln Ile Phe Asn Ser Leu Thr Glu Tyr Ile Gln Gly Pro Cys
    3810                3815                3820                
Ile Gly Asn Gln Gln Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val
3825                3830                3835                3840
Val Gly Phe Leu His Val Phe Ala Asn Met Gln Met Lys Leu Ser Gln
                3845                3850                3855    
Gly Met Trp
            


<210> 6850
<211> 4870
<212> PRT
<213> Homo sapiens

<400> 6850
Met Ala Glu Gly Gly Glu Gly Gly Glu Asp Glu Ile Gln Phe Leu Arg
 1               5                  10                  15      
Thr Glu Asp Glu Val Val Leu Gln Cys Ile Ala Thr Ile His Lys Glu
            20                  25                  30          
Gln Arg Lys Phe Cys Leu Ala Ala Glu Gly Leu Gly Asn Arg Leu Cys
        35                  40                  45              
Phe Leu Glu Pro Thr Ser Glu Ala Lys Tyr Ile Pro Pro Asp Leu Cys
    50                  55                  60                  
Val Cys Asn Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln
65                  70                  75                  80  
Glu Met Leu Ala Asn Thr Gly Glu Asn Gly Gly Glu Gly Ala Ala Gln
                85                  90                  95      
Gly Gly Gly His Arg Thr Leu Leu Tyr Gly His Ala Val Leu Leu Arg
            100                 105                 110         
His Ser Phe Ser Gly Met Tyr Leu Thr Cys Leu Thr Thr Ser Arg Ser
        115                 120                 125             
Gln Thr Asp Lys Leu Ala Phe Asp Val Gly Leu Arg Glu His Ala Thr
    130                 135                 140                 
Gly Glu Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser
145                 150                 155                 160 
Glu Gly Glu Lys Val Arg Ile Gly Asp Asp Leu Ile Leu Val Ser Val
                165                 170                 175     
Ser Ser Glu Arg Tyr Leu His Leu Ser Val Ser Asn Gly Asn Ile Gln
            180                 185                 190         
Val Asp Ala Ser Phe Met Gln Thr Leu Trp Asn Val His Pro Thr Cys
        195                 200                 205             
Ser Gly Ser Ser Ile Glu Glu Gly Tyr Leu Leu Gly Gly His Val Val
    210                 215                 220                 
Arg Leu Phe His Gly His Asp Glu Cys Leu Thr Ile Pro Ser Thr Asp
225                 230                 235                 240 
Gln Asn Asp Ser Gln His Arg Arg Ile Phe Tyr Glu Ala Gly Gly Ala
                245                 250                 255     
Gly Thr Arg Ala Ser Ser Leu Trp Arg Val Glu Pro Leu Arg Ile Ser
            260                 265                 270         
Trp Ser Gly Ser Asn Ile Arg Trp Gly Gln Ala Phe Arg Leu Arg His
        275                 280                 285             
Leu Thr Thr Gly His Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Ile
    290                 295                 300                 
Leu Gln Asp Arg Ala Lys Ser Asp Thr Lys Ser Thr Ala Phe Ser Phe
305                 310                 315                 320 
Arg Ala Ser Lys Glu Leu Lys Glu Lys Leu Asp Ser Ser His Lys Arg
                325                 330                 335     
Asp Ile Glu Gly Met Gly Val Pro Glu Ile Lys Tyr Gly Asp Ser Val
            340                 345                 350         
Cys Phe Val Gln His Ile Ala Ser Gly Leu Trp Val Thr Tyr Lys Ala
        355                 360                 365             
Gln Asp Ala Lys Thr Ser Arg Leu Gly Pro Leu Lys Arg Lys Val Ile
    370                 375                 380                 
Leu His Gln Glu Gly His Met Asp Asp Gly Leu Thr Leu Gln Arg Cys
385                 390                 395                 400 
Gln Arg Glu Glu Ser Gln Ala Ala Arg Ile Ile Arg Asn Thr Thr Ala
                405                 410                 415     
Leu Phe Ser Gln Phe Val Ser Gly Asn Asn Arg Thr Ala Ala Pro Ile
            420                 425                 430         
Thr Leu Pro Ile Glu Glu Val Leu Gln Thr Leu Gln Asp Leu Ile Ala
        435                 440                 445             
Tyr Phe Gln Pro Pro Glu Glu Glu Met Arg His Glu Asp Lys Gln Asn
    450                 455                 460                 
Lys Leu Arg Ser Leu Lys Asn Arg Gln Asn Leu Phe Lys Glu Glu Gly
465                 470                 475                 480 
Met Leu Ala Leu Val Leu Asn Cys Ile Asp Arg Leu Asn Ile Tyr Asn
                485                 490                 495     
Ser Val Ala His Phe Ala Gly Ile Ala Arg Glu Glu Ser Gly Met Ala
            500                 505                 510         
Trp Lys Glu Ile Leu Asn Leu Leu Tyr Lys Leu Leu Ala Ala Leu Ile
        515                 520                 525             
Arg Gly Asn Arg Asn Asn Cys Ala Gln Phe Ser Asn Asn Leu Asp Trp
    530                 535                 540                 
Leu Ile Ser Lys Leu Asp Arg Leu Glu Ser Ser Ser Gly Ile Leu Glu
545                 550                 555                 560 
Val Leu His Cys Ile Leu Thr Glu Ser Pro Glu Ala Leu Asn Leu Ile
                565                 570                 575     
Ala Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly
            580                 585                 590         
Arg Asn His Lys Val Leu Asp Ile Leu Cys Ser Leu Cys Leu Cys Asn
        595                 600                 605             
Gly Val Ala Val Arg Ala Asn Gln Asn Leu Ile Cys Asp Asn Leu Leu
    610                 615                 620                 
Pro Arg Arg Asn Leu Leu Leu Gln Thr Arg Leu Ile Asn Asp Val Thr
625                 630                 635                 640 
Ser Ile Arg Pro Asn Ile Phe Leu Gly Val Ala Glu Gly Ser Ala Gln
                645                 650                 655     
Tyr Lys Lys Trp Tyr Phe Glu Leu Ile Ile Asp Gln Val Asp Pro Phe
            660                 665                 670         
Leu Thr Ala Glu Pro Thr His Leu Arg Val Gly Trp Ala Ser Ser Ser
        675                 680                 685             
Gly Tyr Ala Pro Cys Pro Gly Gly Gly Glu Gly Trp Gly Gly Asn Gly
    690                 695                 700                 
Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu Trp
705                 710                 715                 720 
Ser Gly Arg Ile Pro Arg Ala Val Ala Ser Val Asn Gln His Leu Leu
                725                 730                 735     
Arg Ser Asp Asp Val Val Ser Cys Cys Leu Asp Leu Gly Val Pro Ser
            740                 745                 750         
Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn
        755                 760                 765             
Phe Asn Thr Asp Gly Leu Phe Phe Pro Val Met Ser Phe Ser Ala Gly
    770                 775                 780                 
Val Lys Val Arg Phe Leu Met Gly Gly Arg His Gly Glu Phe Lys Phe
785                 790                 795                 800 
Leu Pro Pro Ser Gly Tyr Ala Pro Cys Tyr Glu Ala Leu Leu Pro Lys
                805                 810                 815     
Glu Lys Met Arg Leu Glu Pro Val Lys Glu Tyr Lys Arg Asp Ala Asp
            820                 825                 830         
Gly Ile Arg Asp Leu Leu Gly Thr Thr Gln Phe Leu Ser Gln Ala Ser
        835                 840                 845             
Phe Ile Pro Cys Pro Val Asp Thr Ser Gln Val Ile Leu Pro Pro His
    850                 855                 860                 
Leu Glu Lys Ile Arg Asp Arg Leu Ala Glu Asn Ile His Glu Leu Trp
865                 870                 875                 880 
Gly Met Asn Lys Ile Glu Leu Gly Trp Thr Phe Gly Lys Ile Arg Asp
                885                 890                 895     
Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro
            900                 905                 910         
Glu Thr Glu Lys Asn Tyr Asn Leu Gln Met Ser Thr Glu Thr Leu Lys
        915                 920                 925             
Thr Leu Leu Ala Leu Gly Cys His Ile Ala His Val Asn Pro Ala Ala
    930                 935                 940                 
Glu Glu Asp Leu Lys Lys Val Lys Leu Pro Lys Asn Tyr Met Met Ser
945                 950                 955                 960 
Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser Asp Val Lys Leu Leu
                965                 970                 975     
Pro Pro Gln Glu Ile Leu Val Asp Lys Leu Ala Glu Asn Ala His Asn
            980                 985                 990         
Val Trp Ala Lys Asp Arg Ile Lys Gln Gly Trp Thr Tyr Gly Ile Gln
        995                 1000                1005            
Gln Asp Leu Lys Asn Lys Arg Asn Pro Arg Leu Val Pro Tyr Ala Leu
    1010                1015                1020                
Leu Asp Glu Arg Thr Lys Lys Ser Asn Arg Asp Ser Leu Arg Glu Ala
1025                1030                1035                1040
Val Arg Thr Phe Val Gly Tyr Gly Tyr Asn Ile Glu Pro Ser Asp Gln
                1045                1050                1055    
Glu Leu Ala Asp Ser Ala Val Glu Lys Val Ser Ile Asp Lys Ile Arg
            1060                1065                1070        
Phe Phe Arg Val Glu Arg Ser Tyr Ala Val Arg Ser Gly Lys Trp Tyr
        1075                1080                1085            
Phe Glu Phe Glu Val Val Thr Gly Gly Asp Met Arg Val Gly Trp Ala
    1090                1095                1100                
Arg Pro Gly Cys Arg Pro Asp Val Glu Leu Gly Ala Asp Asp Gln Ala
1105                1110                1115                1120
Phe Val Phe Glu Gly Asn Arg Gly Gln Arg Trp His Gln Gly Ser Gly
                1125                1130                1135    
Tyr Phe Gly Arg Thr Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile
            1140                1145                1150        
Asn Leu Asp Asp Ala Ser Met Ile Phe Thr Leu Asn Gly Glu Leu Leu
        1155                1160                1165            
Ile Thr Asn Lys Gly Ser Glu Leu Ala Phe Ala Asp Tyr Glu Ile Glu
    1170                1175                1180                
Asn Gly Phe Val Pro Ile Cys Cys Leu Gly Leu Ser Gln Ile Gly Arg
1185                1190                1195                1200
Met Asn Leu Gly Thr Asp Ala Ser Thr Phe Lys Phe Tyr Thr Met Cys
                1205                1210                1215    
Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Val Asn Met Asn Arg Asp
            1220                1225                1230        
Val Ala Met Trp Phe Ser Lys Arg Leu Pro Thr Phe Val Asn Val Pro
        1235                1240                1245            
Lys Asp His Pro His Ile Glu Val Met Arg Ile Asp Gly Thr Met Asp
    1250                1255                1260                
Ser Pro Pro Cys Leu Lys Val Thr His Lys Thr Phe Gly Thr Gln Asn
1265                1270                1275                1280
Ser Asn Ala Asp Met Ile Tyr Cys Arg Leu Ser Met Pro Val Glu Cys
                1285                1290                1295    
His Ser Ser Phe Ser His Ser Pro Cys Leu Asp Ser Glu Ala Phe Gln
            1300                1305                1310        
Lys Arg Lys Gln Met Gln Glu Ile Leu Ser His Thr Thr Thr Gln Cys
        1315                1320                1325            
Tyr Tyr Ala Ile Arg Ile Phe Ala Gly Gln Asp Pro Ser Cys Val Trp
    1330                1335                1340                
Val Gly Trp Val Thr Pro Asp Tyr His Leu Tyr Ser Glu Lys Phe Asp
1345                1350                1355                1360
Leu Asn Lys Asn Cys Thr Val Thr Val Thr Leu Gly Asp Glu Arg Gly
                1365                1370                1375    
Arg Val His Glu Ser Val Lys Arg Ser Asn Cys Tyr Met Val Trp Gly
            1380                1385                1390        
Gly Asp Ile Val Ala Ser Ser Gln Arg Ser Asn Arg Ser Asn Val Asp
        1395                1400                1405            
Leu Glu Ile Gly Cys Leu Val Asp Leu Ala Met Gly Met Leu Ser Phe
    1410                1415                1420                
Ser Ala Asn Gly Lys Glu Leu Gly Thr Cys Tyr Gln Val Glu Pro Asn
1425                1430                1435                1440
Thr Lys Val Phe Pro Ala Val Phe Leu Gln Pro Thr Ser Thr Ser Leu
                1445                1450                1455    
Phe Gln Phe Glu Leu Gly Lys Leu Lys Asn Ala Met Pro Leu Ser Ala
            1460                1465                1470        
Ala Ile Phe Arg Ser Glu Glu Lys Asn Pro Val Pro Gln Cys Pro Pro
        1475                1480                1485            
Arg Leu Asp Val Gln Thr Ile Gln Pro Val Leu Trp Ser Arg Met Pro
    1490                1495                1500                
Asn Ser Phe Leu Lys Val Glu Thr Glu Arg Val Ser Glu Arg His Gly
1505                1510                1515                1520
Trp Val Val Gln Cys Leu Glu Pro Leu Gln Met Met Ala Leu His Ile
                1525                1530                1535    
Pro Glu Glu Asn Arg Cys Val Asp Ile Leu Glu Leu Cys Glu Gln Glu
            1540                1545                1550        
Asp Leu Met Arg Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val
        1555                1560                1565            
Cys Ala Leu Gly Asn Ser Arg Val Ala Tyr Ala Leu Cys Ser His Val
    1570                1575                1580                
Asp Leu Ser Gln Leu Phe Tyr Ala Ile Asp Asn Lys Tyr Leu Pro Gly
1585                1590                1595                1600
Leu Leu Arg Ser Gly Phe Tyr Asp Leu Leu Ile Ser Ile His Leu Ala
                1605                1610                1615    
Ser Ala Lys Glu Arg Lys Leu Met Met Lys Asn Glu Tyr Ile Ile Pro
            1620                1625                1630        
Ile Thr Ser Thr Thr Arg Asn Ile Cys Leu Phe Pro Asp Glu Ser Lys
        1635                1640                1645            
Arg His Gly Leu Pro Gly Val Gly Leu Arg Thr Cys Leu Lys Pro Gly
    1650                1655                1660                
Phe Arg Phe Ser Thr Pro Cys Phe Val Val Thr Gly Glu Asp His Gln
1665                1670                1675                1680
Lys Gln Ser Pro Glu Ile Pro Leu Glu Ser Leu Arg Thr Lys Ala Leu
                1685                1690                1695    
Ser Met Leu Thr Glu Ala Val Gln Cys Ser Gly Ala His Ile Arg Asp
            1700                1705                1710        
Pro Val Gly Gly Ser Val Glu Phe Gln Phe Val Pro Val Leu Lys Leu
        1715                1720                1725            
Ile Gly Thr Leu Leu Val Met Gly Val Phe Asp Asp Asp Asp Val Arg
    1730                1735                1740                
Gln Ile Leu Leu Leu Ile Asp Pro Ser Val Phe Gly Glu His Ser Ala
1745                1750                1755                1760
Gly Thr Glu Glu Gly Ala Glu Lys Glu Glu Val Thr Gln Val Glu Glu
                1765                1770                1775    
Lys Ala Val Glu Ala Gly Glu Lys Ala Gly Lys Glu Ala Pro Val Lys
            1780                1785                1790        
Gly Leu Leu Gln Thr Arg Leu Pro Glu Ser Val Lys Leu Gln Met Cys
        1795                1800                1805            
Glu Leu Leu Ser Tyr Leu Cys Asp Cys Glu Leu Gln His Arg Val Glu
    1810                1815                1820                
Ala Ile Val Ala Phe Gly Asp Ile Tyr Val Ser Lys Leu Gln Ala Asn
1825                1830                1835                1840
Gln Lys Phe Arg Tyr Asn Glu Leu Met Gln Ala Leu Asn Met Ser Ala
                1845                1850                1855    
Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro Pro Gln Glu
            1860                1865                1870        
Gln Ile Asn Met Leu Leu Asn Phe Gln Leu Gly Glu Asn Cys Pro Cys
        1875                1880                1885            
Pro Glu Glu Ile Arg Glu Glu Leu Tyr Asp Phe His Glu Asp Leu Leu
    1890                1895                1900                
Leu His Cys Gly Val Pro Leu Glu Glu Glu Glu Glu Glu Glu Glu Asp
1905                1910                1915                1920
Thr Ser Trp Thr Gly Lys Leu Cys Ala Leu Val Tyr Lys Ile Lys Gly
                1925                1930                1935    
Pro Pro Lys Pro Glu Lys Glu Gln Pro Thr Glu Glu Glu Glu Arg Cys
            1940                1945                1950        
Pro Thr Thr Leu Lys Glu Leu Ile Ser Gln Thr Met Ile Cys Trp Ala
        1955                1960                1965            
Gln Glu Asp Gln Ile Gln Asp Ser Glu Leu Val Arg Met Met Phe Asn
    1970                1975                1980                
Leu Leu Arg Arg Gln Tyr Asp Ser Ile Gly Glu Leu Leu Gln Ala Leu
1985                1990                1995                2000
Arg Lys Thr Tyr Thr Ile Ser His Thr Ser Val Ser Asp Thr Ile Asn
                2005                2010                2015    
Leu Leu Ala Ala Leu Gly Gln Ile Arg Ser Leu Leu Ser Val Arg Met
            2020                2025                2030        
Gly Lys Glu Glu Glu Leu Leu Met Ile Asn Gly Leu Gly Asp Ile Met
        2035                2040                2045            
Asn Asn Lys Val Phe Tyr Gln His Pro Asn Leu Met Arg Val Leu Gly
    2050                2055                2060                
Met His Glu Thr Val Met Glu Val Met Val Asn Val Leu Gly Thr Glu
2065                2070                2075                2080
Lys Ser Gln Ile Ala Phe Pro Lys Met Val Ala Ser Cys Cys Arg Phe
                2085                2090                2095    
Leu Cys Tyr Phe Cys Arg Ile Ser Arg Gln Asn Gln Lys Ala Met Phe
            2100                2105                2110        
Glu His Leu Ser Tyr Leu Leu Glu Asn Ser Ser Val Gly Leu Ala Ser
        2115                2120                2125            
Pro Ser Met Arg Gly Ser Thr Pro Leu Asp Val Ala Ala Ser Ser Val
    2130                2135                2140                
Met Asp Asn Asn Glu Leu Ala Leu Ser Leu Glu Glu Pro Asp Leu Glu
2145                2150                2155                2160
Lys Val Val Thr Tyr Leu Ala Gly Cys Gly Leu Gln Ser Cys Pro Met
                2165                2170                2175    
Leu Leu Ala Lys Gly Tyr Pro Asp Val Gly Trp Asn Pro Ile Glu Gly
            2180                2185                2190        
Glu Arg Tyr Leu Ser Phe Leu Arg Phe Ala Val Phe Val Asn Ser Glu
        2195                2200                2205            
Ser Val Glu Glu Asn Ala Ser Val Val Val Lys Leu Leu Ile Arg Arg
    2210                2215                2220                
Pro Glu Cys Phe Gly Pro Ala Leu Arg Gly Glu Gly Gly Asn Gly Leu
2225                2230                2235                2240
Leu Ala Ala Met Gln Gly Ala Ile Lys Ile Ser Glu Asn Pro Ala Leu
                2245                2250                2255    
Asp Leu Pro Ser Gln Gly Tyr Lys Arg Glu Val Ser Thr Glu Asp Asp
            2260                2265                2270        
Glu Glu Glu Glu Glu Ile Val His Met Gly Asn Ala Ile Met Ser Phe
        2275                2280                2285            
Tyr Ser Ala Leu Ile Asp Leu Leu Gly Arg Cys Ala Pro Glu Met His
    2290                2295                2300                
Leu Ile Gln Thr Gly Lys Gly Glu Ala Ile Arg Ile Arg Ser Ile Leu
2305                2310                2315                2320
Arg Ser Leu Val Pro Thr Glu Asp Leu Val Gly Ile Ile Ser Ile Pro
                2325                2330                2335    
Leu Lys Leu Pro Ser Leu Asn Lys Asp Gly Ser Val Ser Glu Pro Asp
            2340                2345                2350        
Met Ala Ala Asn Phe Cys Pro Asp His Lys Ala Pro Met Val Leu Phe
        2355                2360                2365            
Leu Asp Arg Val Tyr Gly Ile Lys Asp Gln Thr Phe Leu Leu His Leu
    2370                2375                2380                
Leu Glu Val Gly Phe Leu Pro Asp Leu Arg Ala Ser Ala Ser Leu Asp
2385                2390                2395                2400
Thr Val Ser Leu Ser Thr Thr Glu Ala Ala Leu Ala Leu Asn Arg Tyr
                2405                2410                2415    
Ile Cys Ser Ala Val Leu Pro Leu Leu Thr Arg Cys Ala Pro Leu Phe
            2420                2425                2430        
Ala Gly Thr Glu His Cys Thr Ser Leu Ile Asp Ser Thr Leu Gln Thr
        2435                2440                2445            
Ile Tyr Arg Leu Ser Lys Gly Arg Ser Leu Thr Lys Ala Gln Arg Asp
    2450                2455                2460                
Thr Ile Glu Glu Cys Leu Leu Ala Ile Cys Asn His Leu Arg Pro Ser
2465                2470                2475                2480
Met Leu Gln Gln Leu Leu Arg Arg Leu Val Phe Asp Val Pro Gln Leu
                2485                2490                2495    
Asn Glu Tyr Cys Lys Met Pro Leu Lys Leu Leu Thr Asn His Tyr Glu
            2500                2505                2510        
Gln Cys Trp Lys Tyr Tyr Cys Leu Pro Ser Gly Trp Gly Ser Tyr Gly
        2515                2520                2525            
Leu Ala Val Glu Glu Glu Leu His Leu Thr Glu Lys Leu Phe Trp Gly
    2530                2535                2540                
Ile Phe Asp Ser Leu Ser His Lys Lys Tyr Asp Pro Asp Leu Phe Arg
2545                2550                2555                2560
Met Ala Leu Pro Cys Leu Ser Ala Ile Ala Gly Ala Leu Pro Pro Asp
                2565                2570                2575    
Tyr Leu Asp Thr Arg Ile Thr Ala Thr Leu Glu Lys Gln Ile Ser Val
            2580                2585                2590        
Asp Ala Asp Gly Asn Phe Asp Pro Lys Pro Ile Asn Thr Met Asn Phe
        2595                2600                2605            
Ser Leu Pro Glu Lys Leu Glu Tyr Ile Val Thr Lys Tyr Ala Glu His
    2610                2615                2620                
Ser His Asp Lys Trp Ala Cys Asp Lys Ser Gln Ser Gly Trp Lys Tyr
2625                2630                2635                2640
Gly Ile Ser Leu Asp Glu Asn Val Lys Thr His Pro Leu Ile Arg Pro
                2645                2650                2655    
Phe Lys Thr Leu Thr Glu Lys Glu Lys Glu Ile Tyr Arg Trp Pro Ala
            2660                2665                2670        
Arg Glu Ser Leu Lys Thr Met Leu Ala Val Gly Trp Thr Val Glu Arg
        2675                2680                2685            
Thr Lys Glu Gly Glu Ala Leu Val Gln Gln Arg Glu Asn Glu Lys Leu
    2690                2695                2700                
Arg Ser Val Ser Gln Ala Asn Gln Gly Asn Ser Tyr Ser Pro Ala Pro
2705                2710                2715                2720
Leu Asp Leu Ser Asn Val Val Leu Ser Arg Glu Leu Gln Gly Met Val
                2725                2730                2735    
Glu Val Val Ala Glu Asn Tyr His Asn Ile Trp Ala Lys Lys Lys Lys
            2740                2745                2750        
Leu Glu Leu Glu Ser Lys Gly Gly Gly Ser His Pro Leu Leu Val Pro
        2755                2760                2765            
Tyr Asp Thr Leu Thr Ala Lys Glu Lys Phe Lys Asp Arg Glu Lys Ala
    2770                2775                2780                
Gln Asp Leu Phe Lys Phe Leu Gln Val Asn Gly Ile Ile Val Ser Arg
2785                2790                2795                2800
Gly Met Lys Asp Met Glu Leu Asp Ala Ser Ser Met Glu Lys Arg Phe
                2805                2810                2815    
Ala Tyr Lys Phe Leu Lys Lys Ile Leu Lys Tyr Val Asp Ser Ala Gln
            2820                2825                2830        
Glu Phe Ile Ala His Leu Glu Ala Ile Val Ser Ser Gly Lys Thr Glu
        2835                2840                2845            
Lys Ser Pro Arg Asp Gln Glu Ile Lys Phe Phe Ala Lys Val Leu Leu
    2850                2855                2860                
Pro Leu Val Asp Gln Tyr Phe Thr Ser His Cys Leu Tyr Phe Leu Ser
2865                2870                2875                2880
Ser Pro Leu Lys Pro Leu Ser Ser Ser Gly Tyr Ala Ser His Lys Glu
                2885                2890                2895    
Lys Glu Met Val Ala Gly Leu Phe Cys Lys Leu Ala Ala Leu Val Arg
            2900                2905                2910        
His Arg Ile Ser Leu Phe Gly Ser Asp Ser Thr Thr Met Val Ser Cys
        2915                2920                2925            
Leu His Ile Leu Ala Gln Thr Leu Asp Thr Arg Thr Val Met Lys Ser
    2930                2935                2940                
Gly Ser Glu Leu Val Lys Ala Gly Leu Arg Ala Phe Phe Glu Asn Ala
2945                2950                2955                2960
Ala Glu Asp Leu Glu Lys Thr Ser Glu Asn Leu Lys Leu Gly Lys Phe
                2965                2970                2975    
Thr His Ser Arg Thr Gln Ile Lys Gly Val Ser Gln Asn Ile Asn Tyr
            2980                2985                2990        
Thr Thr Val Ala Leu Leu Pro Ile Leu Thr Ser Ile Phe Glu His Val
        2995                3000                3005            
Thr Gln His Gln Phe Gly Met Asp Leu Leu Leu Gly Asp Val Gln Ile
    3010                3015                3020                
Ser Cys Tyr His Ile Leu Cys Ser Leu Tyr Ser Leu Gly Thr Gly Lys
3025                3030                3035                3040
Asn Ile Tyr Val Glu Arg Gln Arg Pro Ala Leu Gly Glu Cys Leu Ala
                3045                3050                3055    
Ser Leu Ala Ala Ala Ile Pro Val Ala Phe Leu Glu Pro Thr Leu Asn
            3060                3065                3070        
Arg Tyr Asn Pro Leu Ser Val Phe Asn Thr Lys Thr Pro Arg Glu Arg
        3075                3080                3085            
Ser Ile Leu Gly Met Pro Asp Thr Val Glu Asp Met Cys Pro Asp Ile
    3090                3095                3100                
Pro Gln Leu Glu Gly Leu Met Lys Glu Ile Asn Asp Leu Ala Glu Ser
3105                3110                3115                3120
Gly Ala Arg Tyr Thr Glu Met Pro His Val Ile Glu Val Ile Leu Pro
                3125                3130                3135    
Met Leu Cys Asn Tyr Leu Ser Tyr Trp Trp Glu Arg Gly Pro Glu Asn
            3140                3145                3150        
Leu Pro Pro Ser Thr Gly Pro Cys Cys Thr Lys Val Thr Ser Glu His
        3155                3160                3165            
Leu Ser Leu Ile Leu Gly Asn Ile Leu Lys Ile Ile Asn Asn Asn Leu
    3170                3175                3180                
Gly Ile Asp Glu Ala Ser Trp Met Lys Arg Ile Ala Val Tyr Ala Gln
3185                3190                3195                3200
Pro Ile Ile Ser Lys Ala Arg Pro Asp Leu Leu Arg Ser His Phe Ile
                3205                3210                3215    
Pro Thr Leu Glu Lys Leu Lys Lys Lys Ala Val Lys Thr Val Gln Glu
            3220                3225                3230        
Glu Glu Gln Leu Lys Ala Asp Gly Lys Gly Asp Thr Gln Glu Ala Glu
        3235                3240                3245            
Leu Leu Ile Leu Asp Glu Phe Ala Val Leu Cys Arg Asp Leu Tyr Ala
    3250                3255                3260                
Phe Tyr Pro Met Leu Ile Arg Tyr Val Asp Asn Asn Arg Ser Asn Trp
3265                3270                3275                3280
Leu Lys Ser Pro Asp Ala Asp Ser Asp Gln Leu Phe Arg Met Val Ala
                3285                3290                3295    
Glu Val Phe Ile Leu Trp Cys Lys Ser His Asn Phe Lys Arg Glu Glu
            3300                3305                3310        
Gln Asn Phe Val Ile Gln Asn Glu Ile Asn Asn Leu Ala Phe Leu Thr
        3315                3320                3325            
Gly Asp Ser Lys Ser Lys Met Ser Lys Ala Met Gln Val Lys Ser Gly
    3330                3335                3340                
Gly Gln Asp Gln Glu Arg Lys Lys Thr Lys Arg Arg Gly Asp Leu Tyr
3345                3350                3355                3360
Ser Ile Gln Thr Ser Leu Ile Val Ala Ala Leu Lys Lys Met Leu Pro
                3365                3370                3375    
Ile Gly Leu Asn Met Cys Thr Pro Gly Asp Gln Glu Leu Ile Ser Leu
            3380                3385                3390        
Ala Lys Ser Arg Tyr Ser His Arg Asp Thr Asp Glu Glu Val Arg Glu
        3395                3400                3405            
His Leu Arg Asn Asn Leu His Leu Gln Glu Lys Ser Asp Asp Pro Ala
    3410                3415                3420                
Val Lys Trp Gln Leu Asn Leu Tyr Lys Asp Val Leu Lys Ser Glu Glu
3425                3430                3435                3440
Pro Phe Asn Pro Glu Lys Thr Val Glu Arg Val Gln Arg Ile Ser Ala
                3445                3450                3455    
Ala Val Phe His Leu Glu Gln Val Glu Gln Pro Leu Arg Ser Lys Lys
            3460                3465                3470        
Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Lys Arg Ala Val Val
        3475                3480                3485            
Ala Cys Phe Arg Met Ala Pro Leu Tyr Asn Leu Pro Arg His Arg Ser
    3490                3495                3500                
Ile Asn Leu Phe Leu His Gly Tyr Gln Arg Phe Trp Ile Glu Thr Glu
3505                3510                3515                3520
Glu Tyr Ser Phe Glu Glu Lys Leu Val Gln Asp Leu Ala Lys Ser Pro
                3525                3530                3535    
Lys Val Glu Glu Glu Glu Glu Glu Glu Thr Glu Lys Gln Pro Asp Pro
            3540                3545                3550        
Leu His Gln Ile Ile Leu Tyr Phe Ser Arg Asn Ala Leu Thr Glu Arg
        3555                3560                3565            
Ser Lys Leu Glu Asp Asp Pro Leu Tyr Thr Ser Tyr Ser Ser Met Met
    3570                3575                3580                
Ala Lys Ser Cys Gln Ser Gly Glu Asp Glu Glu Glu Asp Glu Asp Lys
3585                3590                3595                3600
Glu Lys Thr Phe Glu Glu Lys Glu Met Glu Lys Gln Lys Thr Leu Tyr
                3605                3610                3615    
Gln Gln Ala Arg Leu His Glu Arg Gly Ala Ala Glu Met Val Leu Gln
            3620                3625                3630        
Met Ile Ser Ala Ser Lys Gly Glu Met Ser Pro Met Val Val Glu Thr
        3635                3640                3645            
Leu Lys Leu Gly Ile Ala Ile Leu Asn Gly Gly Asn Ala Gly Val Gln
    3650                3655                3660                
Gln Lys Met Leu Asp Tyr Leu Lys Glu Lys Lys Asp Ala Gly Phe Phe
3665                3670                3675                3680
Gln Ser Leu Ser Gly Leu Met Gln Ser Cys Ser Val Leu Asp Leu Asn
                3685                3690                3695    
Ala Phe Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly Met Val Thr Glu
            3700                3705                3710        
Glu Gly Thr Leu Ile Val Arg Glu Arg Gly Glu Lys Val Leu Gln Asn
        3715                3720                3725            
Asp Glu Phe Thr Arg Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu
    3730                3735                3740                
Gly His Asn Ser Asp Phe Gln Asn Phe Leu Arg Thr Gln Met Gly Asn
3745                3750                3755                3760
Thr Thr Thr Val Asn Val Ile Ile Ser Thr Val Asp Tyr Leu Leu Arg
                3765                3770                3775    
Leu Gln Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp
            3780                3785                3790        
Ile Ile Asp Glu Ser Gly Gln His Asn Phe Ser Lys Ala Leu Ala Val
        3795                3800                3805            
Thr Lys Gln Ile Phe Asn Ser Leu Thr Glu Tyr Ile Gln Gly Pro Cys
    3810                3815                3820                
Ile Gly Asn Gln Gln Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val
3825                3830                3835                3840
Val Gly Phe Leu His Val Phe Ala Asn Met Gln Met Lys Leu Ser Gln
                3845                3850                3855    
Asp Ser Ser Gln Ile Glu Leu Leu Lys Glu Leu Leu Asp Leu Leu Gln
            3860                3865                3870        
Asp Met Val Val Met Leu Leu Ser Leu Leu Glu Gly Asn Val Val Asn
        3875                3880                3885            
Gly Thr Ile Gly Lys Gln Met Val Asp Thr Leu Val Glu Ser Ser Thr
    3890                3895                3900                
Asn Val Glu Met Ile Leu Lys Phe Phe Asp Met Phe Leu Lys Leu Lys
3905                3910                3915                3920
Asp Leu Thr Ser Ser Asp Thr Phe Lys Glu Tyr Asp Pro Asp Gly Lys
                3925                3930                3935    
Gly Ile Ile Ser Lys Lys Glu Phe Gln Lys Ala Met Glu Gly Gln Lys
            3940                3945                3950        
Gln Tyr Thr Gln Ser Glu Ile Asp Phe Leu Leu Ser Cys Ala Glu Ala
        3955                3960                3965            
Asp Glu Asn Asp Met Phe Asn Tyr Val Asp Phe Val Asp Arg Phe His
    3970                3975                3980                
Glu Pro Ala Lys Asp Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn
3985                3990                3995                4000
Leu Ser Glu His Met Pro Asn Asp Ser Arg Leu Lys Cys Leu Leu Asp
                4005                4010                4015    
Pro Ala Glu Ser Val Leu Asn Tyr Phe Glu Pro Tyr Leu Gly Arg Ile
            4020                4025                4030        
Glu Ile Met Gly Gly Ala Lys Lys Ile Glu Arg Val Tyr Phe Glu Ile
        4035                4040                4045            
Ser Glu Ser Ser Arg Thr Gln Trp Glu Lys Pro Gln Val Lys Glu Ser
    4050                4055                4060                
Lys Arg Gln Phe Ile Phe Asp Val Val Asn Glu Gly Gly Glu Gln Glu
4065                4070                4075                4080
Lys Met Glu Leu Phe Val Asn Phe Cys Glu Asp Thr Ile Phe Glu Met
                4085                4090                4095    
Gln Leu Ala Ser Gln Ile Ser Glu Ser Asp Ser Ala Asp Arg Pro Glu
            4100                4105                4110        
Glu Glu Glu Glu Asp Glu Asp Ser Ser Tyr Val Leu Glu Ile Ala Gly
        4115                4120                4125            
Glu Glu Glu Glu Asp Gly Ser Leu Glu Pro Ala Ser Ala Phe Ala Met
    4130                4135                4140                
Ala Cys Ala Ser Val Lys Arg Asn Val Thr Asp Phe Leu Lys Arg Ala
4145                4150                4155                4160
Thr Leu Lys Asn Leu Arg Lys Gln Tyr Arg Asn Val Lys Lys Met Thr
                4165                4170                4175    
Ala Lys Glu Leu Val Lys Val Leu Phe Ser Phe Phe Trp Met Leu Phe
            4180                4185                4190        
Val Gly Leu Phe Gln Leu Leu Phe Thr Ile Leu Gly Gly Ile Phe Gln
        4195                4200                4205            
Ile Leu Trp Ser Thr Val Phe Gly Gly Gly Leu Val Glu Gly Ala Lys
    4210                4215                4220                
Asn Ile Arg Val Thr Lys Ile Leu Gly Asp Met Pro Asp Pro Thr Gln
4225                4230                4235                4240
Phe Gly Ile His Asp Asp Thr Met Glu Ala Glu Arg Ala Glu Val Met
                4245                4250                4255    
Glu Pro Gly Ile Thr Thr Glu Leu Val His Phe Ile Lys Gly Glu Lys
            4260                4265                4270        
Gly Asp Thr Asp Ile Met Ser Asp Leu Phe Gly Leu His Pro Lys Lys
        4275                4280                4285            
Glu Gly Ser Leu Lys His Gly Pro Glu Val Gly Leu Gly Asp Leu Ser
    4290                4295                4300                
Glu Ile Ile Gly Lys Asp Glu Pro Pro Thr Leu Glu Ser Thr Val Gln
4305                4310                4315                4320
Lys Lys Arg Lys Ala Gln Ala Ala Glu Met Lys Ala Ala Asn Glu Ala
                4325                4330                4335    
Glu Gly Lys Val Glu Ser Glu Lys Ala Asp Met Glu Asp Gly Glu Lys
            4340                4345                4350        
Glu Asp Lys Asp Lys Glu Glu Glu Gln Ala Glu Tyr Leu Trp Thr Glu
        4355                4360                4365            
Val Thr Lys Lys Lys Lys Arg Arg Cys Gly Gln Lys Val Glu Lys Pro
    4370                4375                4380                
Glu Ala Phe Thr Ala Asn Phe Phe Lys Gly Leu Glu Ile Tyr Gln Thr
4385                4390                4395                4400
Lys Leu Leu His Tyr Leu Ala Arg Asn Phe Tyr Asn Leu Arg Phe Leu
                4405                4410                4415    
Ala Leu Phe Val Ala Phe Ala Ile Asn Phe Ile Leu Leu Phe Tyr Lys
            4420                4425                4430        
Val Thr Glu Glu Pro Leu Glu Glu Glu Thr Glu Asp Val Ala Asn Leu
        4435                4440                4445            
Trp Asn Ser Phe Asn Asp Glu Glu Glu Glu Glu Ala Met Val Phe Phe
    4450                4455                4460                
Val Leu Gln Glu Ser Thr Gly Tyr Met Ala Pro Thr Leu Arg Ala Leu
4465                4470                4475                4480
Ala Ile Ile His Thr Ile Ile Ser Leu Val Cys Val Val Gly Tyr Tyr
                4485                4490                4495    
Cys Leu Lys Val Pro Leu Val Val Phe Lys Arg Glu Lys Glu Ile Ala
            4500                4505                4510        
Arg Lys Leu Glu Phe Asp Gly Leu Tyr Ile Thr Glu Gln Pro Ser Glu
        4515                4520                4525            
Asp Asp Ile Lys Gly Gln Trp Asp Arg Leu Val Ile Asn Thr Pro Ser
    4530                4535                4540                
Phe Pro Asn Asn Tyr Trp Asp Lys Phe Val Lys Arg Lys Val Ile Asn
4545                4550                4555                4560
Lys Tyr Gly Asp Leu Tyr Gly Ala Glu Arg Ile Ala Glu Leu Leu Gly
                4565                4570                4575    
Leu Asp Lys Asn Ala Leu Asp Phe Ser Pro Val Glu Glu Thr Lys Ala
            4580                4585                4590        
Glu Ala Ala Ser Leu Val Ser Trp Leu Ser Ser Ile Asp Met Lys Tyr
        4595                4600                4605            
His Ile Trp Lys Leu Gly Val Val Phe Thr Asp Asn Ser Phe Leu Tyr
    4610                4615                4620                
Leu Ala Trp Tyr Thr Thr Met Ser Val Leu Gly His Tyr Asn Asn Phe
4625                4630                4635                4640
Phe Phe Ala Ala His Leu Leu Asp Ile Ala Met Gly Phe Lys Thr Leu
                4645                4650                4655    
Arg Thr Ile Leu Ser Ser Val Thr His Asn Gly Lys Gln Leu Val Leu
            4660                4665                4670        
Thr Val Gly Leu Leu Ala Val Val Val Tyr Leu Tyr Thr Val Val Ala
        4675                4680                4685            
Phe Asn Phe Phe Arg Lys Phe Tyr Asn Lys Ser Glu Asp Asp Asp Glu
    4690                4695                4700                
Pro Asp Met Lys Cys Asp Asp Met Met Thr Cys Tyr Leu Phe His Met
4705                4710                4715                4720
Tyr Val Gly Val Arg Ala Gly Gly Gly Ile Gly Asp Glu Ile Glu Asp
                4725                4730                4735    
Pro Ala Gly Asp Pro Tyr Glu Met Tyr Arg Ile Val Phe Asp Ile Thr
            4740                4745                4750        
Phe Phe Phe Phe Val Ile Val Ile Leu Leu Ala Ile Ile Gln Gly Leu
        4755                4760                4765            
Ile Ile Asp Ala Phe Gly Glu Leu Arg Asp Gln Gln Glu Gln Val Arg
    4770                4775                4780                
Glu Asp Met Glu Thr Lys Cys Phe Ile Cys Gly Ile Gly Asn Asp Tyr
4785                4790                4795                4800
Phe Asp Thr Thr Pro His Gly Phe Glu Thr His Thr Leu Gln Glu His
                4805                4810                4815    
Asn Leu Ala Asn Tyr Leu Phe Phe Leu Met Tyr Leu Ile Asn Lys Asp
            4820                4825                4830        
Glu Thr Glu His Thr Gly Gln Glu Ser Tyr Val Trp Lys Met Tyr Gln
        4835                4840                4845            
Glu Arg Cys Trp Asp Phe Phe Pro Ala Gly Asp Cys Phe Arg Lys Gln
    4850                4855                4860                
Tyr Glu Asp Gln Leu Gly
4865                4870


<210> 6851
<211> 4865
<212> PRT
<213> Homo sapiens

<400> 6851
Met Ala Glu Gly Gly Glu Gly Gly Glu Asp Glu Ile Gln Phe Leu Arg
 1               5                  10                  15      
Thr Glu Asp Glu Val Val Leu Gln Cys Ile Ala Thr Ile His Lys Glu
            20                  25                  30          
Gln Arg Lys Phe Cys Leu Ala Ala Glu Gly Leu Gly Asn Arg Leu Cys
        35                  40                  45              
Phe Leu Glu Pro Thr Ser Glu Ala Lys Tyr Ile Pro Pro Asp Leu Cys
    50                  55                  60                  
Val Cys Asn Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln
65                  70                  75                  80  
Glu Met Leu Ala Asn Thr Gly Glu Asn Gly Gly Glu Gly Ala Ala Gln
                85                  90                  95      
Gly Gly Gly His Arg Thr Leu Leu Tyr Gly His Ala Val Leu Leu Arg
            100                 105                 110         
His Ser Phe Ser Gly Met Tyr Leu Thr Cys Leu Thr Thr Ser Arg Ser
        115                 120                 125             
Gln Thr Asp Lys Leu Ala Phe Asp Val Gly Leu Arg Glu His Ala Thr
    130                 135                 140                 
Gly Glu Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser
145                 150                 155                 160 
Glu Gly Glu Lys Val Arg Ile Gly Asp Asp Leu Ile Leu Val Ser Val
                165                 170                 175     
Ser Ser Glu Arg Tyr Leu His Leu Ser Val Ser Asn Gly Asn Ile Gln
            180                 185                 190         
Val Asp Ala Ser Phe Met Gln Thr Leu Trp Asn Val His Pro Thr Cys
        195                 200                 205             
Ser Gly Ser Ser Ile Glu Glu Gly Tyr Leu Leu Gly Gly His Val Val
    210                 215                 220                 
Arg Leu Phe His Gly His Asp Glu Cys Leu Thr Ile Pro Ser Thr Asp
225                 230                 235                 240 
Gln Asn Asp Ser Gln His Arg Arg Ile Phe Tyr Glu Ala Gly Gly Ala
                245                 250                 255     
Gly Thr Arg Ala Ser Ser Leu Trp Arg Val Glu Pro Leu Arg Ile Ser
            260                 265                 270         
Trp Ser Gly Ser Asn Ile Arg Trp Gly Gln Ala Phe Arg Leu Arg His
        275                 280                 285             
Leu Thr Thr Gly His Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Ile
    290                 295                 300                 
Leu Gln Asp Arg Ala Lys Ser Asp Thr Lys Ser Thr Ala Phe Ser Phe
305                 310                 315                 320 
Arg Ala Ser Lys Glu Leu Lys Glu Lys Leu Asp Ser Ser His Lys Arg
                325                 330                 335     
Asp Ile Glu Gly Met Gly Val Pro Glu Ile Lys Tyr Gly Asp Ser Val
            340                 345                 350         
Cys Phe Val Gln His Ile Ala Ser Gly Leu Trp Val Thr Tyr Lys Ala
        355                 360                 365             
Gln Asp Ala Lys Thr Ser Arg Leu Gly Pro Leu Lys Arg Lys Val Ile
    370                 375                 380                 
Leu His Gln Glu Gly His Met Asp Asp Gly Leu Thr Leu Gln Arg Cys
385                 390                 395                 400 
Gln Arg Glu Glu Ser Gln Ala Ala Arg Ile Ile Arg Asn Thr Thr Ala
                405                 410                 415     
Leu Phe Ser Gln Phe Val Ser Gly Asn Asn Arg Thr Ala Ala Pro Ile
            420                 425                 430         
Thr Leu Pro Ile Glu Glu Val Leu Gln Thr Leu Gln Asp Leu Ile Ala
        435                 440                 445             
Tyr Phe Gln Pro Pro Glu Glu Glu Met Arg His Glu Asp Lys Gln Asn
    450                 455                 460                 
Lys Leu Arg Ser Leu Lys Asn Arg Gln Asn Leu Phe Lys Glu Glu Gly
465                 470                 475                 480 
Met Leu Ala Leu Val Leu Asn Cys Ile Asp Arg Leu Asn Ile Tyr Asn
                485                 490                 495     
Ser Val Ala His Phe Ala Gly Ile Ala Arg Glu Glu Ser Gly Met Ala
            500                 505                 510         
Trp Lys Glu Ile Leu Asn Leu Leu Tyr Lys Leu Leu Ala Ala Leu Ile
        515                 520                 525             
Arg Gly Asn Arg Asn Asn Cys Ala Gln Phe Ser Asn Asn Leu Asp Trp
    530                 535                 540                 
Leu Ile Ser Lys Leu Asp Arg Leu Glu Ser Ser Ser Gly Ile Leu Glu
545                 550                 555                 560 
Val Leu His Cys Ile Leu Thr Glu Ser Pro Glu Ala Leu Asn Leu Ile
                565                 570                 575     
Ala Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly
            580                 585                 590         
Arg Asn His Lys Val Leu Asp Ile Leu Cys Ser Leu Cys Leu Cys Asn
        595                 600                 605             
Gly Val Ala Val Arg Ala Asn Gln Asn Leu Ile Cys Asp Asn Leu Leu
    610                 615                 620                 
Pro Arg Arg Asn Leu Leu Leu Gln Thr Arg Leu Ile Asn Asp Val Thr
625                 630                 635                 640 
Ser Ile Arg Pro Asn Ile Phe Leu Gly Val Ala Glu Gly Ser Ala Gln
                645                 650                 655     
Tyr Lys Lys Trp Tyr Phe Glu Leu Ile Ile Asp Gln Val Asp Pro Phe
            660                 665                 670         
Leu Thr Ala Glu Pro Thr His Leu Arg Val Gly Trp Ala Ser Ser Ser
        675                 680                 685             
Gly Tyr Ala Pro Cys Pro Gly Gly Gly Glu Gly Trp Gly Gly Asn Gly
    690                 695                 700                 
Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu Trp
705                 710                 715                 720 
Ser Gly Arg Ile Pro Arg Ala Val Ala Ser Val Asn Gln His Leu Leu
                725                 730                 735     
Arg Ser Asp Asp Val Val Ser Cys Cys Leu Asp Leu Gly Val Pro Ser
            740                 745                 750         
Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn
        755                 760                 765             
Phe Asn Thr Asp Gly Leu Phe Phe Pro Val Met Ser Phe Ser Ala Gly
    770                 775                 780                 
Val Lys Val Arg Phe Leu Met Gly Gly Arg His Gly Glu Phe Lys Phe
785                 790                 795                 800 
Leu Pro Pro Ser Gly Tyr Ala Pro Cys Tyr Glu Ala Leu Leu Pro Lys
                805                 810                 815     
Glu Lys Met Arg Leu Glu Pro Val Lys Glu Tyr Lys Arg Asp Ala Asp
            820                 825                 830         
Gly Ile Arg Asp Leu Leu Gly Thr Thr Gln Phe Leu Ser Gln Ala Ser
        835                 840                 845             
Phe Ile Pro Cys Pro Val Asp Thr Ser Gln Val Ile Leu Pro Pro His
    850                 855                 860                 
Leu Glu Lys Ile Arg Asp Arg Leu Ala Glu Asn Ile His Glu Leu Trp
865                 870                 875                 880 
Gly Met Asn Lys Ile Glu Leu Gly Trp Thr Phe Gly Lys Ile Arg Asp
                885                 890                 895     
Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro
            900                 905                 910         
Glu Thr Glu Lys Asn Tyr Asn Leu Gln Met Ser Thr Glu Thr Leu Lys
        915                 920                 925             
Thr Leu Leu Ala Leu Gly Cys His Ile Ala His Val Asn Pro Ala Ala
    930                 935                 940                 
Glu Glu Asp Leu Lys Lys Val Lys Leu Pro Lys Asn Tyr Met Met Ser
945                 950                 955                 960 
Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser Asp Val Lys Leu Leu
                965                 970                 975     
Pro Pro Gln Glu Ile Leu Val Asp Lys Leu Ala Glu Asn Ala His Asn
            980                 985                 990         
Val Trp Ala Lys Asp Arg Ile Lys Gln Gly Trp Thr Tyr Gly Ile Gln
        995                 1000                1005            
Gln Asp Leu Lys Asn Lys Arg Asn Pro Arg Leu Val Pro Tyr Ala Leu
    1010                1015                1020                
Leu Asp Glu Arg Thr Lys Lys Ser Asn Arg Asp Ser Leu Arg Glu Ala
1025                1030                1035                1040
Val Arg Thr Phe Val Gly Tyr Gly Tyr Asn Ile Glu Pro Ser Asp Gln
                1045                1050                1055    
Glu Leu Ala Asp Ser Ala Val Glu Lys Val Ser Ile Asp Lys Ile Arg
            1060                1065                1070        
Phe Phe Arg Val Glu Arg Ser Tyr Ala Val Arg Ser Gly Lys Trp Tyr
        1075                1080                1085            
Phe Glu Phe Glu Val Val Thr Gly Gly Asp Met Arg Val Gly Trp Ala
    1090                1095                1100                
Arg Pro Gly Cys Arg Pro Asp Val Glu Leu Gly Ala Asp Asp Gln Ala
1105                1110                1115                1120
Phe Val Phe Glu Gly Asn Arg Gly Gln Arg Trp His Gln Gly Ser Gly
                1125                1130                1135    
Tyr Phe Gly Arg Thr Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile
            1140                1145                1150        
Asn Leu Asp Asp Ala Ser Met Ile Phe Thr Leu Asn Gly Glu Leu Leu
        1155                1160                1165            
Ile Thr Asn Lys Gly Ser Glu Leu Ala Phe Ala Asp Tyr Glu Ile Glu
    1170                1175                1180                
Asn Gly Phe Val Pro Ile Cys Cys Leu Gly Leu Ser Gln Ile Gly Arg
1185                1190                1195                1200
Met Asn Leu Gly Thr Asp Ala Ser Thr Phe Lys Phe Tyr Thr Met Cys
                1205                1210                1215    
Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Val Asn Met Asn Arg Asp
            1220                1225                1230        
Val Ala Met Trp Phe Ser Lys Arg Leu Pro Thr Phe Val Asn Val Pro
        1235                1240                1245            
Lys Asp His Pro His Ile Glu Val Met Arg Ile Asp Gly Thr Met Asp
    1250                1255                1260                
Ser Pro Pro Cys Leu Lys Val Thr His Lys Thr Phe Gly Thr Gln Asn
1265                1270                1275                1280
Ser Asn Ala Asp Met Ile Tyr Cys Arg Leu Ser Met Pro Val Glu Cys
                1285                1290                1295    
His Ser Ser Phe Ser His Ser Pro Cys Leu Asp Ser Glu Ala Phe Gln
            1300                1305                1310        
Lys Arg Lys Gln Met Gln Glu Ile Leu Ser His Thr Thr Thr Gln Cys
        1315                1320                1325            
Tyr Tyr Ala Ile Arg Ile Phe Ala Gly Gln Asp Pro Ser Cys Val Trp
    1330                1335                1340                
Val Gly Trp Val Thr Pro Asp Tyr His Leu Tyr Ser Glu Lys Phe Asp
1345                1350                1355                1360
Leu Asn Lys Asn Cys Thr Val Thr Val Thr Leu Gly Asp Glu Arg Gly
                1365                1370                1375    
Arg Val His Glu Ser Val Lys Arg Ser Asn Cys Tyr Met Val Trp Gly
            1380                1385                1390        
Gly Asp Ile Val Ala Ser Ser Gln Arg Ser Asn Arg Ser Asn Val Asp
        1395                1400                1405            
Leu Glu Ile Gly Cys Leu Val Asp Leu Ala Met Gly Met Leu Ser Phe
    1410                1415                1420                
Ser Ala Asn Gly Lys Glu Leu Gly Thr Cys Tyr Gln Val Glu Pro Asn
1425                1430                1435                1440
Thr Lys Val Phe Pro Ala Val Phe Leu Gln Pro Thr Ser Thr Ser Leu
                1445                1450                1455    
Phe Gln Phe Glu Leu Gly Lys Leu Lys Asn Ala Met Pro Leu Ser Ala
            1460                1465                1470        
Ala Ile Phe Arg Ser Glu Glu Lys Asn Pro Val Pro Gln Cys Pro Pro
        1475                1480                1485            
Arg Leu Asp Val Gln Thr Ile Gln Pro Val Leu Trp Ser Arg Met Pro
    1490                1495                1500                
Asn Ser Phe Leu Lys Val Glu Thr Glu Arg Val Ser Glu Arg His Gly
1505                1510                1515                1520
Trp Val Val Gln Cys Leu Glu Pro Leu Gln Met Met Ala Leu His Ile
                1525                1530                1535    
Pro Glu Glu Asn Arg Cys Val Asp Ile Leu Glu Leu Cys Glu Gln Glu
            1540                1545                1550        
Asp Leu Met Arg Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val
        1555                1560                1565            
Cys Ala Leu Gly Asn Ser Arg Val Ala Tyr Ala Leu Cys Ser His Val
    1570                1575                1580                
Asp Leu Ser Gln Leu Phe Tyr Ala Ile Asp Asn Lys Tyr Leu Pro Gly
1585                1590                1595                1600
Leu Leu Arg Ser Gly Phe Tyr Asp Leu Leu Ile Ser Ile His Leu Ala
                1605                1610                1615    
Ser Ala Lys Glu Arg Lys Leu Met Met Lys Asn Glu Tyr Ile Ile Pro
            1620                1625                1630        
Ile Thr Ser Thr Thr Arg Asn Ile Cys Leu Phe Pro Asp Glu Ser Lys
        1635                1640                1645            
Arg His Gly Leu Pro Gly Val Gly Leu Arg Thr Cys Leu Lys Pro Gly
    1650                1655                1660                
Phe Arg Phe Ser Thr Pro Cys Phe Val Val Thr Gly Glu Asp His Gln
1665                1670                1675                1680
Lys Gln Ser Pro Glu Ile Pro Leu Glu Ser Leu Arg Thr Lys Ala Leu
                1685                1690                1695    
Ser Met Leu Thr Glu Ala Val Gln Cys Ser Gly Ala His Ile Arg Asp
            1700                1705                1710        
Pro Val Gly Gly Ser Val Glu Phe Gln Phe Val Pro Val Leu Lys Leu
        1715                1720                1725            
Ile Gly Thr Leu Leu Val Met Gly Val Phe Asp Asp Asp Asp Val Arg
    1730                1735                1740                
Gln Ile Leu Leu Leu Ile Asp Pro Ser Val Phe Gly Glu His Ser Ala
1745                1750                1755                1760
Gly Thr Glu Glu Gly Ala Glu Lys Glu Glu Val Thr Gln Val Glu Glu
                1765                1770                1775    
Lys Ala Val Glu Ala Gly Glu Lys Ala Gly Lys Glu Ala Pro Val Lys
            1780                1785                1790        
Gly Leu Leu Gln Thr Arg Leu Pro Glu Ser Val Lys Leu Gln Met Cys
        1795                1800                1805            
Glu Leu Leu Ser Tyr Leu Cys Asp Cys Glu Leu Gln His Arg Val Glu
    1810                1815                1820                
Ala Ile Val Ala Phe Gly Asp Ile Tyr Val Ser Lys Leu Gln Ala Asn
1825                1830                1835                1840
Gln Lys Phe Arg Tyr Asn Glu Leu Met Gln Ala Leu Asn Met Ser Ala
                1845                1850                1855    
Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro Pro Gln Glu
            1860                1865                1870        
Gln Ile Asn Met Leu Leu Asn Phe Gln Leu Gly Glu Asn Cys Pro Cys
        1875                1880                1885            
Pro Glu Glu Ile Arg Glu Glu Leu Tyr Asp Phe His Glu Asp Leu Leu
    1890                1895                1900                
Leu His Cys Gly Val Pro Leu Glu Glu Glu Glu Glu Glu Glu Glu Asp
1905                1910                1915                1920
Thr Ser Trp Thr Gly Lys Leu Cys Ala Leu Val Tyr Lys Ile Lys Gly
                1925                1930                1935    
Pro Pro Lys Pro Glu Lys Glu Gln Pro Thr Glu Glu Glu Glu Arg Cys
            1940                1945                1950        
Pro Thr Thr Leu Lys Glu Leu Ile Ser Gln Thr Met Ile Cys Trp Ala
        1955                1960                1965            
Gln Glu Asp Gln Ile Gln Asp Ser Glu Leu Val Arg Met Met Phe Asn
    1970                1975                1980                
Leu Leu Arg Arg Gln Tyr Asp Ser Ile Gly Glu Leu Leu Gln Ala Leu
1985                1990                1995                2000
Arg Lys Thr Tyr Thr Ile Ser His Thr Ser Val Ser Asp Thr Ile Asn
                2005                2010                2015    
Leu Leu Ala Ala Leu Gly Gln Ile Arg Ser Leu Leu Ser Val Arg Met
            2020                2025                2030        
Gly Lys Glu Glu Glu Leu Leu Met Ile Asn Gly Leu Gly Asp Ile Met
        2035                2040                2045            
Asn Asn Lys Val Phe Tyr Gln His Pro Asn Leu Met Arg Val Leu Gly
    2050                2055                2060                
Met His Glu Thr Val Met Glu Val Met Val Asn Val Leu Gly Thr Glu
2065                2070                2075                2080
Lys Ser Gln Ile Ala Phe Pro Lys Met Val Ala Ser Cys Cys Arg Phe
                2085                2090                2095    
Leu Cys Tyr Phe Cys Arg Ile Ser Arg Gln Asn Gln Lys Ala Met Phe
            2100                2105                2110        
Glu His Leu Ser Tyr Leu Leu Glu Asn Ser Ser Val Gly Leu Ala Ser
        2115                2120                2125            
Pro Ser Met Arg Gly Ser Thr Pro Leu Asp Val Ala Ala Ser Ser Val
    2130                2135                2140                
Met Asp Asn Asn Glu Leu Ala Leu Ser Leu Glu Glu Pro Asp Leu Glu
2145                2150                2155                2160
Lys Val Val Thr Tyr Leu Ala Gly Cys Gly Leu Gln Ser Cys Pro Met
                2165                2170                2175    
Leu Leu Ala Lys Gly Tyr Pro Asp Val Gly Trp Asn Pro Ile Glu Gly
            2180                2185                2190        
Glu Arg Tyr Leu Ser Phe Leu Arg Phe Ala Val Phe Val Asn Ser Glu
        2195                2200                2205            
Ser Val Glu Glu Asn Ala Ser Val Val Val Lys Leu Leu Ile Arg Arg
    2210                2215                2220                
Pro Glu Cys Phe Gly Pro Ala Leu Arg Gly Glu Gly Gly Asn Gly Leu
2225                2230                2235                2240
Leu Ala Ala Met Gln Gly Ala Ile Lys Ile Ser Glu Asn Pro Ala Leu
                2245                2250                2255    
Asp Leu Pro Ser Gln Gly Tyr Lys Arg Glu Val Ser Thr Glu Asp Asp
            2260                2265                2270        
Glu Glu Glu Glu Glu Ile Val His Met Gly Asn Ala Ile Met Ser Phe
        2275                2280                2285            
Tyr Ser Ala Leu Ile Asp Leu Leu Gly Arg Cys Ala Pro Glu Met His
    2290                2295                2300                
Leu Ile Gln Thr Gly Lys Gly Glu Ala Ile Arg Ile Arg Ser Ile Leu
2305                2310                2315                2320
Arg Ser Leu Val Pro Thr Glu Asp Leu Val Gly Ile Ile Ser Ile Pro
                2325                2330                2335    
Leu Lys Leu Pro Ser Leu Asn Lys Asp Gly Ser Val Ser Glu Pro Asp
            2340                2345                2350        
Met Ala Ala Asn Phe Cys Pro Asp His Lys Ala Pro Met Val Leu Phe
        2355                2360                2365            
Leu Asp Arg Val Tyr Gly Ile Lys Asp Gln Thr Phe Leu Leu His Leu
    2370                2375                2380                
Leu Glu Val Gly Phe Leu Pro Asp Leu Arg Ala Ser Ala Ser Leu Asp
2385                2390                2395                2400
Thr Val Ser Leu Ser Thr Thr Glu Ala Ala Leu Ala Leu Asn Arg Tyr
                2405                2410                2415    
Ile Cys Ser Ala Val Leu Pro Leu Leu Thr Arg Cys Ala Pro Leu Phe
            2420                2425                2430        
Ala Gly Thr Glu His Cys Thr Ser Leu Ile Asp Ser Thr Leu Gln Thr
        2435                2440                2445            
Ile Tyr Arg Leu Ser Lys Gly Arg Ser Leu Thr Lys Ala Gln Arg Asp
    2450                2455                2460                
Thr Ile Glu Glu Cys Leu Leu Ala Ile Cys Asn His Leu Arg Pro Ser
2465                2470                2475                2480
Met Leu Gln Gln Leu Leu Arg Arg Leu Val Phe Asp Val Pro Gln Leu
                2485                2490                2495    
Asn Glu Tyr Cys Lys Met Pro Leu Lys Leu Leu Thr Asn His Tyr Glu
            2500                2505                2510        
Gln Cys Trp Lys Tyr Tyr Cys Leu Pro Ser Gly Trp Gly Ser Tyr Gly
        2515                2520                2525            
Leu Ala Val Glu Glu Glu Leu His Leu Thr Glu Lys Leu Phe Trp Gly
    2530                2535                2540                
Ile Phe Asp Ser Leu Ser His Lys Lys Tyr Asp Pro Asp Leu Phe Arg
2545                2550                2555                2560
Met Ala Leu Pro Cys Leu Ser Ala Ile Ala Gly Ala Leu Pro Pro Asp
                2565                2570                2575    
Tyr Leu Asp Thr Arg Ile Thr Ala Thr Leu Glu Lys Gln Ile Ser Val
            2580                2585                2590        
Asp Ala Asp Gly Asn Phe Asp Pro Lys Pro Ile Asn Thr Met Asn Phe
        2595                2600                2605            
Ser Leu Pro Glu Lys Leu Glu Tyr Ile Val Thr Lys Tyr Ala Glu His
    2610                2615                2620                
Ser His Asp Lys Trp Ala Cys Asp Lys Ser Gln Ser Gly Trp Lys Tyr
2625                2630                2635                2640
Gly Ile Ser Leu Asp Glu Asn Val Lys Thr His Pro Leu Ile Arg Pro
                2645                2650                2655    
Phe Lys Thr Leu Thr Glu Lys Glu Lys Glu Ile Tyr Arg Trp Pro Ala
            2660                2665                2670        
Arg Glu Ser Leu Lys Thr Met Leu Ala Val Gly Trp Thr Val Glu Arg
        2675                2680                2685            
Thr Lys Glu Gly Glu Ala Leu Val Gln Gln Arg Glu Asn Glu Lys Leu
    2690                2695                2700                
Arg Ser Val Ser Gln Ala Asn Gln Gly Asn Ser Tyr Ser Pro Ala Pro
2705                2710                2715                2720
Leu Asp Leu Ser Asn Val Val Leu Ser Arg Glu Leu Gln Gly Met Val
                2725                2730                2735    
Glu Val Val Ala Glu Asn Tyr His Asn Ile Trp Ala Lys Lys Lys Lys
            2740                2745                2750        
Leu Glu Leu Glu Ser Lys Gly Gly Gly Ser His Pro Leu Leu Val Pro
        2755                2760                2765            
Tyr Asp Thr Leu Thr Ala Lys Glu Lys Phe Lys Asp Arg Glu Lys Ala
    2770                2775                2780                
Gln Asp Leu Phe Lys Phe Leu Gln Val Asn Gly Ile Ile Val Ser Arg
2785                2790                2795                2800
Gly Met Lys Asp Met Glu Leu Asp Ala Ser Ser Met Glu Lys Arg Phe
                2805                2810                2815    
Ala Tyr Lys Phe Leu Lys Lys Ile Leu Lys Tyr Val Asp Ser Ala Gln
            2820                2825                2830        
Glu Phe Ile Ala His Leu Glu Ala Ile Val Ser Ser Gly Lys Thr Glu
        2835                2840                2845            
Lys Ser Pro Arg Asp Gln Glu Ile Lys Phe Phe Ala Lys Val Leu Leu
    2850                2855                2860                
Pro Leu Val Asp Gln Tyr Phe Thr Ser His Cys Leu Tyr Phe Leu Ser
2865                2870                2875                2880
Ser Pro Leu Lys Pro Leu Ser Ser Ser Gly Tyr Ala Ser His Lys Glu
                2885                2890                2895    
Lys Glu Met Val Ala Gly Leu Phe Cys Lys Leu Ala Ala Leu Val Arg
            2900                2905                2910        
His Arg Ile Ser Leu Phe Gly Ser Asp Ser Thr Thr Met Val Ser Cys
        2915                2920                2925            
Leu His Ile Leu Ala Gln Thr Leu Asp Thr Arg Thr Val Met Lys Ser
    2930                2935                2940                
Gly Ser Glu Leu Val Lys Ala Gly Leu Arg Ala Phe Phe Glu Asn Ala
2945                2950                2955                2960
Ala Glu Asp Leu Glu Lys Thr Ser Glu Asn Leu Lys Leu Gly Lys Phe
                2965                2970                2975    
Thr His Ser Arg Thr Gln Ile Lys Gly Val Ser Gln Asn Ile Asn Tyr
            2980                2985                2990        
Thr Thr Val Ala Leu Leu Pro Ile Leu Thr Ser Ile Phe Glu His Val
        2995                3000                3005            
Thr Gln His Gln Phe Gly Met Asp Leu Leu Leu Gly Asp Val Gln Ile
    3010                3015                3020                
Ser Cys Tyr His Ile Leu Cys Ser Leu Tyr Ser Leu Gly Thr Gly Lys
3025                3030                3035                3040
Asn Ile Tyr Val Glu Arg Gln Arg Pro Ala Leu Gly Glu Cys Leu Ala
                3045                3050                3055    
Ser Leu Ala Ala Ala Ile Pro Val Ala Phe Leu Glu Pro Thr Leu Asn
            3060                3065                3070        
Arg Tyr Asn Pro Leu Ser Val Phe Asn Thr Lys Thr Pro Arg Glu Arg
        3075                3080                3085            
Ser Ile Leu Gly Met Pro Asp Thr Val Glu Asp Met Cys Pro Asp Ile
    3090                3095                3100                
Pro Gln Leu Glu Gly Leu Met Lys Glu Ile Asn Asp Leu Ala Glu Ser
3105                3110                3115                3120
Gly Ala Arg Tyr Thr Glu Met Pro His Val Ile Glu Val Ile Leu Pro
                3125                3130                3135    
Met Leu Cys Asn Tyr Leu Ser Tyr Trp Trp Glu Arg Gly Pro Glu Asn
            3140                3145                3150        
Leu Pro Pro Ser Thr Gly Pro Cys Cys Thr Lys Val Thr Ser Glu His
        3155                3160                3165            
Leu Ser Leu Ile Leu Gly Asn Ile Leu Lys Ile Ile Asn Asn Asn Leu
    3170                3175                3180                
Gly Ile Asp Glu Ala Ser Trp Met Lys Arg Ile Ala Val Tyr Ala Gln
3185                3190                3195                3200
Pro Ile Ile Ser Lys Ala Arg Pro Asp Leu Leu Arg Ser His Phe Ile
                3205                3210                3215    
Pro Thr Leu Glu Lys Leu Lys Lys Lys Ala Val Lys Thr Val Gln Glu
            3220                3225                3230        
Glu Glu Gln Leu Lys Ala Asp Gly Lys Gly Asp Thr Gln Glu Ala Glu
        3235                3240                3245            
Leu Leu Ile Leu Asp Glu Phe Ala Val Leu Cys Arg Asp Leu Tyr Ala
    3250                3255                3260                
Phe Tyr Pro Met Leu Ile Arg Tyr Val Asp Asn Asn Arg Ser Asn Trp
3265                3270                3275                3280
Leu Lys Ser Pro Asp Ala Asp Ser Asp Gln Leu Phe Arg Met Val Ala
                3285                3290                3295    
Glu Val Phe Ile Leu Trp Cys Lys Ser His Asn Phe Lys Arg Glu Glu
            3300                3305                3310        
Gln Asn Phe Val Ile Gln Asn Glu Ile Asn Asn Leu Ala Phe Leu Thr
        3315                3320                3325            
Gly Asp Ser Lys Ser Lys Met Ser Lys Ser Gly Gly Gln Asp Gln Glu
    3330                3335                3340                
Arg Lys Lys Thr Lys Arg Arg Gly Asp Leu Tyr Ser Ile Gln Thr Ser
3345                3350                3355                3360
Leu Ile Val Ala Ala Leu Lys Lys Met Leu Pro Ile Gly Leu Asn Met
                3365                3370                3375    
Cys Thr Pro Gly Asp Gln Glu Leu Ile Ser Leu Ala Lys Ser Arg Tyr
            3380                3385                3390        
Ser His Arg Asp Thr Asp Glu Glu Val Arg Glu His Leu Arg Asn Asn
        3395                3400                3405            
Leu His Leu Gln Glu Lys Ser Asp Asp Pro Ala Val Lys Trp Gln Leu
    3410                3415                3420                
Asn Leu Tyr Lys Asp Val Leu Lys Ser Glu Glu Pro Phe Asn Pro Glu
3425                3430                3435                3440
Lys Thr Val Glu Arg Val Gln Arg Ile Ser Ala Ala Val Phe His Leu
                3445                3450                3455    
Glu Gln Val Glu Gln Pro Leu Arg Ser Lys Lys Ala Val Trp His Lys
            3460                3465                3470        
Leu Leu Ser Lys Gln Arg Lys Arg Ala Val Val Ala Cys Phe Arg Met
        3475                3480                3485            
Ala Pro Leu Tyr Asn Leu Pro Arg His Arg Ser Ile Asn Leu Phe Leu
    3490                3495                3500                
His Gly Tyr Gln Arg Phe Trp Ile Glu Thr Glu Glu Tyr Ser Phe Glu
3505                3510                3515                3520
Glu Lys Leu Val Gln Asp Leu Ala Lys Ser Pro Lys Val Glu Glu Glu
                3525                3530                3535    
Glu Glu Glu Glu Thr Glu Lys Gln Pro Asp Pro Leu His Gln Ile Ile
            3540                3545                3550        
Leu Tyr Phe Ser Arg Asn Ala Leu Thr Glu Arg Ser Lys Leu Glu Asp
        3555                3560                3565            
Asp Pro Leu Tyr Thr Ser Tyr Ser Ser Met Met Ala Lys Ser Cys Gln
    3570                3575                3580                
Ser Gly Glu Asp Glu Glu Glu Asp Glu Asp Lys Glu Lys Thr Phe Glu
3585                3590                3595                3600
Glu Lys Glu Met Glu Lys Gln Lys Thr Leu Tyr Gln Gln Ala Arg Leu
                3605                3610                3615    
His Glu Arg Gly Ala Ala Glu Met Val Leu Gln Met Ile Ser Ala Ser
            3620                3625                3630        
Lys Gly Glu Met Ser Pro Met Val Val Glu Thr Leu Lys Leu Gly Ile
        3635                3640                3645            
Ala Ile Leu Asn Gly Gly Asn Ala Gly Val Gln Gln Lys Met Leu Asp
    3650                3655                3660                
Tyr Leu Lys Glu Lys Lys Asp Ala Gly Phe Phe Gln Ser Leu Ser Gly
3665                3670                3675                3680
Leu Met Gln Ser Cys Ser Val Leu Asp Leu Asn Ala Phe Glu Arg Gln
                3685                3690                3695    
Asn Lys Ala Glu Gly Leu Gly Met Val Thr Glu Glu Gly Thr Leu Ile
            3700                3705                3710        
Val Arg Glu Arg Gly Glu Lys Val Leu Gln Asn Asp Glu Phe Thr Arg
        3715                3720                3725            
Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu Gly His Asn Ser Asp
    3730                3735                3740                
Phe Gln Asn Phe Leu Arg Thr Gln Met Gly Asn Thr Thr Thr Val Asn
3745                3750                3755                3760
Val Ile Ile Ser Thr Val Asp Tyr Leu Leu Arg Leu Gln Glu Ser Ile
                3765                3770                3775    
Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp Ile Ile Asp Glu Ser
            3780                3785                3790        
Gly Gln His Asn Phe Ser Lys Ala Leu Ala Val Thr Lys Gln Ile Phe
        3795                3800                3805            
Asn Ser Leu Thr Glu Tyr Ile Gln Gly Pro Cys Ile Gly Asn Gln Gln
    3810                3815                3820                
Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val Val Gly Phe Leu His
3825                3830                3835                3840
Val Phe Ala Asn Met Gln Met Lys Leu Ser Gln Asp Ser Ser Gln Ile
                3845                3850                3855    
Glu Leu Leu Lys Glu Leu Leu Asp Leu Leu Gln Asp Met Val Val Met
            3860                3865                3870        
Leu Leu Ser Leu Leu Glu Gly Asn Val Val Asn Gly Thr Ile Gly Lys
        3875                3880                3885            
Gln Met Val Asp Thr Leu Val Glu Ser Ser Thr Asn Val Glu Met Ile
    3890                3895                3900                
Leu Lys Phe Phe Asp Met Phe Leu Lys Leu Lys Asp Leu Thr Ser Ser
3905                3910                3915                3920
Asp Thr Phe Lys Glu Tyr Asp Pro Asp Gly Lys Gly Ile Ile Ser Lys
                3925                3930                3935    
Lys Glu Phe Gln Lys Ala Met Glu Gly Gln Lys Gln Tyr Thr Gln Ser
            3940                3945                3950        
Glu Ile Asp Phe Leu Leu Ser Cys Ala Glu Ala Asp Glu Asn Asp Met
        3955                3960                3965            
Phe Asn Tyr Val Asp Phe Val Asp Arg Phe His Glu Pro Ala Lys Asp
    3970                3975                3980                
Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn Leu Ser Glu His Met
3985                3990                3995                4000
Pro Asn Asp Ser Arg Leu Lys Cys Leu Leu Asp Pro Ala Glu Ser Val
                4005                4010                4015    
Leu Asn Tyr Phe Glu Pro Tyr Leu Gly Arg Ile Glu Ile Met Gly Gly
            4020                4025                4030        
Ala Lys Lys Ile Glu Arg Val Tyr Phe Glu Ile Ser Glu Ser Ser Arg
        4035                4040                4045            
Thr Gln Trp Glu Lys Pro Gln Val Lys Glu Ser Lys Arg Gln Phe Ile
    4050                4055                4060                
Phe Asp Val Val Asn Glu Gly Gly Glu Gln Glu Lys Met Glu Leu Phe
4065                4070                4075                4080
Val Asn Phe Cys Glu Asp Thr Ile Phe Glu Met Gln Leu Ala Ser Gln
                4085                4090                4095    
Ile Ser Glu Ser Asp Ser Ala Asp Arg Pro Glu Glu Glu Glu Glu Asp
            4100                4105                4110        
Glu Asp Ser Ser Tyr Val Leu Glu Ile Ala Gly Glu Glu Glu Glu Asp
        4115                4120                4125            
Gly Ser Leu Glu Pro Ala Ser Ala Phe Ala Met Ala Cys Ala Ser Val
    4130                4135                4140                
Lys Arg Asn Val Thr Asp Phe Leu Lys Arg Ala Thr Leu Lys Asn Leu
4145                4150                4155                4160
Arg Lys Gln Tyr Arg Asn Val Lys Lys Met Thr Ala Lys Glu Leu Val
                4165                4170                4175    
Lys Val Leu Phe Ser Phe Phe Trp Met Leu Phe Val Gly Leu Phe Gln
            4180                4185                4190        
Leu Leu Phe Thr Ile Leu Gly Gly Ile Phe Gln Ile Leu Trp Ser Thr
        4195                4200                4205            
Val Phe Gly Gly Gly Leu Val Glu Gly Ala Lys Asn Ile Arg Val Thr
    4210                4215                4220                
Lys Ile Leu Gly Asp Met Pro Asp Pro Thr Gln Phe Gly Ile His Asp
4225                4230                4235                4240
Asp Thr Met Glu Ala Glu Arg Ala Glu Val Met Glu Pro Gly Ile Thr
                4245                4250                4255    
Thr Glu Leu Val His Phe Ile Lys Gly Glu Lys Gly Asp Thr Asp Ile
            4260                4265                4270        
Met Ser Asp Leu Phe Gly Leu His Pro Lys Lys Glu Gly Ser Leu Lys
        4275                4280                4285            
His Gly Pro Glu Val Gly Leu Gly Asp Leu Ser Glu Ile Ile Gly Lys
    4290                4295                4300                
Asp Glu Pro Pro Thr Leu Glu Ser Thr Val Gln Lys Lys Arg Lys Ala
4305                4310                4315                4320
Gln Ala Ala Glu Met Lys Ala Ala Asn Glu Ala Glu Gly Lys Val Glu
                4325                4330                4335    
Ser Glu Lys Ala Asp Met Glu Asp Gly Glu Lys Glu Asp Lys Asp Lys
            4340                4345                4350        
Glu Glu Glu Gln Ala Glu Tyr Leu Trp Thr Glu Val Thr Lys Lys Lys
        4355                4360                4365            
Lys Arg Arg Cys Gly Gln Lys Val Glu Lys Pro Glu Ala Phe Thr Ala
    4370                4375                4380                
Asn Phe Phe Lys Gly Leu Glu Ile Tyr Gln Thr Lys Leu Leu His Tyr
4385                4390                4395                4400
Leu Ala Arg Asn Phe Tyr Asn Leu Arg Phe Leu Ala Leu Phe Val Ala
                4405                4410                4415    
Phe Ala Ile Asn Phe Ile Leu Leu Phe Tyr Lys Val Thr Glu Glu Pro
            4420                4425                4430        
Leu Glu Glu Glu Thr Glu Asp Val Ala Asn Leu Trp Asn Ser Phe Asn
        4435                4440                4445            
Asp Glu Glu Glu Glu Glu Ala Met Val Phe Phe Val Leu Gln Glu Ser
    4450                4455                4460                
Thr Gly Tyr Met Ala Pro Thr Leu Arg Ala Leu Ala Ile Ile His Thr
4465                4470                4475                4480
Ile Ile Ser Leu Val Cys Val Val Gly Tyr Tyr Cys Leu Lys Val Pro
                4485                4490                4495    
Leu Val Val Phe Lys Arg Glu Lys Glu Ile Ala Arg Lys Leu Glu Phe
            4500                4505                4510        
Asp Gly Leu Tyr Ile Thr Glu Gln Pro Ser Glu Asp Asp Ile Lys Gly
        4515                4520                4525            
Gln Trp Asp Arg Leu Val Ile Asn Thr Pro Ser Phe Pro Asn Asn Tyr
    4530                4535                4540                
Trp Asp Lys Phe Val Lys Arg Lys Val Ile Asn Lys Tyr Gly Asp Leu
4545                4550                4555                4560
Tyr Gly Ala Glu Arg Ile Ala Glu Leu Leu Gly Leu Asp Lys Asn Ala
                4565                4570                4575    
Leu Asp Phe Ser Pro Val Glu Glu Thr Lys Ala Glu Ala Ala Ser Leu
            4580                4585                4590        
Val Ser Trp Leu Ser Ser Ile Asp Met Lys Tyr His Ile Trp Lys Leu
        4595                4600                4605            
Gly Val Val Phe Thr Asp Asn Ser Phe Leu Tyr Leu Ala Trp Tyr Thr
    4610                4615                4620                
Thr Met Ser Val Leu Gly His Tyr Asn Asn Phe Phe Phe Ala Ala His
4625                4630                4635                4640
Leu Leu Asp Ile Ala Met Gly Phe Lys Thr Leu Arg Thr Ile Leu Ser
                4645                4650                4655    
Ser Val Thr His Asn Gly Lys Gln Leu Val Leu Thr Val Gly Leu Leu
            4660                4665                4670        
Ala Val Val Val Tyr Leu Tyr Thr Val Val Ala Phe Asn Phe Phe Arg
        4675                4680                4685            
Lys Phe Tyr Asn Lys Ser Glu Asp Asp Asp Glu Pro Asp Met Lys Cys
    4690                4695                4700                
Asp Asp Met Met Thr Cys Tyr Leu Phe His Met Tyr Val Gly Val Arg
4705                4710                4715                4720
Ala Gly Gly Gly Ile Gly Asp Glu Ile Glu Asp Pro Ala Gly Asp Pro
                4725                4730                4735    
Tyr Glu Met Tyr Arg Ile Val Phe Asp Ile Thr Phe Phe Phe Phe Val
            4740                4745                4750        
Ile Val Ile Leu Leu Ala Ile Ile Gln Gly Leu Ile Ile Asp Ala Phe
        4755                4760                4765            
Gly Glu Leu Arg Asp Gln Gln Glu Gln Val Arg Glu Asp Met Glu Thr
    4770                4775                4780                
Lys Cys Phe Ile Cys Gly Ile Gly Asn Asp Tyr Phe Asp Thr Thr Pro
4785                4790                4795                4800
His Gly Phe Glu Thr His Thr Leu Gln Glu His Asn Leu Ala Asn Tyr
                4805                4810                4815    
Leu Phe Phe Leu Met Tyr Leu Ile Asn Lys Asp Glu Thr Glu His Thr
            4820                4825                4830        
Gly Gln Glu Ser Tyr Val Trp Lys Met Tyr Gln Glu Arg Cys Trp Asp
        4835                4840                4845            
Phe Phe Pro Ala Gly Asp Cys Phe Arg Lys Gln Tyr Glu Asp Gln Leu
    4850                4855                4860                
Gly
4865


<210> 6852
<211> 368
<212> PRT
<213> Homo sapiens

<400> 6852
Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala
 1               5                  10                  15      
Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly
            20                  25                  30          
Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly
        35                  40                  45              
Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro
    50                  55                  60                  
Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly
65                  70                  75                  80  
Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp
                85                  90                  95      
Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly
            100                 105                 110         
Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys
        115                 120                 125             
Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr
    130                 135                 140                 
Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser
145                 150                 155                 160 
Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys
                165                 170                 175     
Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly
            180                 185                 190         
Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu
        195                 200                 205             
Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro
    210                 215                 220                 
Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys
225                 230                 235                 240 
Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr
                245                 250                 255     
Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser
            260                 265                 270         
Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys
        275                 280                 285             
Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val
    290                 295                 300                 
Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe
305                 310                 315                 320 
Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser
                325                 330                 335     
Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe
            340                 345                 350         
Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys
        355                 360                 365             


<210> 6853
<211> 325
<212> PRT
<213> Homo sapiens

<400> 6853
Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala
 1               5                  10                  15      
Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly
            20                  25                  30          
Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly
        35                  40                  45              
Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro
    50                  55                  60                  
Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly
65                  70                  75                  80  
Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp
                85                  90                  95      
Leu Gln Lys Leu Tyr Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro
            100                 105                 110         
Asn Leu Pro Ser Ser Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile
        115                 120                 125             
Arg Lys Val Pro Lys Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys
    130                 135                 140                 
Ile Glu Met Gly Gly Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly
145                 150                 155                 160 
Ala Phe Asp Gly Leu Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys
                165                 170                 175     
Leu Thr Gly Ile Pro Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His
            180                 185                 190         
Leu Asp His Asn Lys Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg
        195                 200                 205             
Tyr Ser Lys Leu Tyr Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met
    210                 215                 220                 
Ile Glu Asn Gly Ser Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His
225                 230                 235                 240 
Leu Asp Asn Asn Lys Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu
                245                 250                 255     
Lys Leu Leu Gln Val Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val
            260                 265                 270         
Gly Val Asn Asp Phe Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr
        275                 280                 285             
Tyr Asn Gly Ile Ser Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val
    290                 295                 300                 
Gln Pro Ala Thr Phe Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe
305                 310                 315                 320 
Gly Asn Tyr Lys Lys
                325 


<210> 6854
<211> 450
<212> PRT
<213> Homo sapiens

<400> 6854
Met Leu Ile Met Pro Lys Ala Leu Lys Glu Glu Ser Glu Asp Thr Cys
 1               5                  10                  15      
Leu Glu Thr Leu Ala Val Pro Ser Glu Cys Ser Ala Phe Ser Glu Asn
            20                  25                  30          
Ile Glu Asp Pro Gly Glu Gly Pro Ser Asn Pro Cys Leu Asp Thr Ser
        35                  40                  45              
Gln Asp Gln Pro Ser Met Glu Ser Glu Met Gly Ala Ala Ala Cys Pro
    50                  55                  60                  
Gly Ser Cys Ser Arg Glu Cys Glu Val Ser Phe Ser Ala Ser Asn Pro
65                  70                  75                  80  
Val Trp Asp Tyr Ser His Leu Met Ser Ser Glu Arg Asn Phe Gln Arg
                85                  90                  95      
Leu Asp Phe Glu Glu Leu Glu Glu Glu Gly Gln Ala Ser Asp Lys Ser
            100                 105                 110         
Leu Leu Pro Ser Arg Ile Asn Leu Ser Leu Leu Asp Asp Asp Glu Glu
        115                 120                 125             
Asp Glu Glu Leu Pro Arg Phe Ile Leu His Tyr Glu Thr His Pro Phe
    130                 135                 140                 
Glu Thr Gly Met Ile Val Trp Phe Lys Tyr Gln Lys Tyr Pro Phe Trp
145                 150                 155                 160 
Pro Ala Val Ile Lys Ser Ile Arg Arg Lys Glu Arg Lys Ala Ser Val
                165                 170                 175     
Leu Phe Val Glu Ala Asn Met Asn Ser Glu Lys Lys Gly Ile Arg Val
            180                 185                 190         
Asn Phe Arg Arg Leu Lys Lys Phe Asp Cys Lys Glu Lys Gln Met Leu
        195                 200                 205             
Val Asp Lys Ala Arg Glu Asp Tyr Ser Glu Ser Ile Asp Trp Cys Ile
    210                 215                 220                 
Ser Leu Ile Cys Asp Tyr Arg Val Arg Ile Gly Cys Gly Ser Phe Thr
225                 230                 235                 240 
Gly Ser Leu Leu Glu Tyr Tyr Ala Ala Asp Ile Ser Tyr Pro Val Arg
                245                 250                 255     
Lys Glu Thr Lys Gln Asp Thr Phe Arg Asn Lys Phe Pro Lys Leu His
            260                 265                 270         
Asn Glu Asp Ala Arg Glu Pro Met Ala Val Thr Ser Gln Thr Lys Lys
        275                 280                 285             
Met Ser Phe Gln Lys Ile Leu Pro Asp Arg Met Lys Ala Ala Arg Asp
    290                 295                 300                 
Arg Ala Asn Lys Asn Leu Val Asp Phe Ile Val Asn Ala Lys Gly Thr
305                 310                 315                 320 
Glu Asn His Leu Leu Ala Ile Val Asn Gly Thr Lys Gly Ser Arg Trp
                325                 330                 335     
Leu Lys Ser Phe Leu Asn Ala Asn Arg Phe Thr Pro Cys Ile Glu Thr
            340                 345                 350         
Tyr Phe Glu Asp Glu Asp Gln Leu Asp Glu Val Val Lys Tyr Leu Gln
        355                 360                 365             
Glu Val Cys Asn Gln Ile Asp Gln Ile Met Pro Thr Trp Ile Lys Asp
    370                 375                 380                 
Asp Lys Ile Lys Phe Ile Leu Glu Val Leu Leu Pro Glu Ala Ile Ile
385                 390                 395                 400 
Cys Ser Ile Ser Ala Val Asp Gly Leu Asp Tyr Glu Ala Ala Glu Ala
                405                 410                 415     
Lys Tyr Leu Lys Gly Pro Cys Leu Gly Tyr Arg Glu Arg Glu Leu Phe
            420                 425                 430         
Asp Ala Lys Ile Ile Tyr Glu Lys Arg Arg Lys Ala Pro Thr Asn Glu
        435                 440                 445             
Ala His
    450 


<210> 6855
<211> 637
<212> PRT
<213> Homo sapiens

<400> 6855
Met Glu Ser Glu Tyr Val Leu Cys Asp Trp Lys Asp Gln Leu Trp Pro
 1               5                  10                  15      
Ala Lys Val Leu Ser Arg Ser Glu Thr Ser Ser Asn Ser Lys Arg Lys
            20                  25                  30          
Lys Ala Phe Ser Leu Glu Val Gln Ile Leu Ser Leu Asp Glu Lys Ile
        35                  40                  45              
Lys Leu Asp Ser Thr Glu Thr Lys Ile Leu Asn Lys Ser Gln Ile Glu
    50                  55                  60                  
Ala Ile Ala Ala Ser Leu Gly Leu Gln Ser Glu Asp Ser Ala Pro Pro
65                  70                  75                  80  
Thr Glu Glu Thr Ala Tyr Gly Arg Ser Leu Lys Val Ala Leu Gly Ile
                85                  90                  95      
Leu Asn Glu Arg Thr Asn Leu Ser Gln Ala Ser Thr Ser Asp Glu Glu
            100                 105                 110         
Glu Ile Thr Met Leu Ser Gln Asn Val Pro Gln Lys Gln Ser Asp Ser
        115                 120                 125             
Pro Pro His Lys Lys Tyr Arg Lys Asp Glu Gly Asp Leu Pro Gly Cys
    130                 135                 140                 
Leu Glu Glu Arg Glu Asn Ser Ala Cys Leu Leu Ala Ser Ser Glu Ser
145                 150                 155                 160 
Asp Asp Ser Leu Tyr Asp Asp Lys Ser Gln Ala Pro Thr Met Val Asp
                165                 170                 175     
Thr Ile Pro Ser Glu Val Glu Thr Lys Ser Leu Gln Asn Ser Ser Trp
            180                 185                 190         
Cys Glu Thr Phe Pro Ser Leu Ser Glu Asp Asn Asp Glu Lys Glu Asn
        195                 200                 205             
Lys Asn Lys Ile Asp Ile Ser Ala Val Met Ser Val His Ser Ala Val
    210                 215                 220                 
Lys Glu Glu Ser Ala Cys Val Lys Asp Glu Lys Phe Ala Pro Pro Leu
225                 230                 235                 240 
Ser Pro Leu Ser Ser Asp Met Leu Ile Met Pro Lys Ala Leu Lys Glu
                245                 250                 255     
Glu Ser Glu Asp Thr Cys Leu Glu Thr Leu Ala Val Pro Ser Glu Cys
            260                 265                 270         
Ser Ala Phe Ser Glu Asn Ile Glu Asp Pro Gly Glu Gly Pro Ser Asn
        275                 280                 285             
Pro Cys Leu Asp Thr Ser Gln Asn Gln Pro Ser Met Glu Ser Glu Met
    290                 295                 300                 
Gly Ala Ala Ala Cys Pro Gly Ser Cys Ser Arg Glu Cys Glu Val Ser
305                 310                 315                 320 
Phe Ser Ala Ser Asn Pro Val Trp Asp Tyr Ser His Leu Met Ser Ser
                325                 330                 335     
Glu Arg Asn Phe Gln Arg Leu Asp Phe Glu Glu Leu Glu Glu Glu Gly
            340                 345                 350         
Gln Ala Ser Asp Lys Ser Leu Leu Pro Ser Arg Ile Asn Leu Ser Leu
        355                 360                 365             
Leu Asp Asp Asp Glu Glu Asp Glu Glu Leu Pro Arg Phe Ile Leu His
    370                 375                 380                 
Tyr Glu Thr His Pro Phe Glu Thr Gly Met Ile Val Trp Phe Lys Tyr
385                 390                 395                 400 
Gln Lys Tyr Pro Phe Trp Pro Ala Val Ile Lys Ser Ile Arg Arg Lys
                405                 410                 415     
Glu Arg Lys Ala Ser Val Leu Phe Val Glu Ala Asn Met Asn Ser Glu
            420                 425                 430         
Lys Lys Gly Ile Arg Val Asn Phe Arg Arg Leu Lys Lys Phe Asp Cys
        435                 440                 445             
Lys Glu Lys Gln Met Leu Val Asp Lys Ala Arg Glu Asp Tyr Ser Glu
    450                 455                 460                 
Ser Ile Asp Trp Cys Ile Ser Leu Ile Cys Asp Tyr Arg Val Arg Ile
465                 470                 475                 480 
Gly Cys Gly Ser Phe Thr Gly Ser Leu Leu Glu Tyr Tyr Ala Ala Asp
                485                 490                 495     
Ile Ser Tyr Pro Val Arg Lys Glu Thr Lys Gln Asp Thr Phe Arg Asn
            500                 505                 510         
Lys Phe Pro Lys Leu His Asn Glu Asp Ala Arg Glu Pro Met Ala Val
        515                 520                 525             
Thr Ser Gln Thr Lys Lys Met Ser Phe Gln Lys Ile Leu Pro Asp Arg
    530                 535                 540                 
Met Lys Ala Ala Arg Asp Arg Ala Asn Lys Asn Leu Val Asp Phe Ile
545                 550                 555                 560 
Val Asn Ala Lys Gly Thr Glu Asn His Leu Leu Ala Ile Val Asn Gly
                565                 570                 575     
Thr Lys Gly Ser Arg Trp Leu Lys Ser Phe Leu Asn Ala Asn Arg Phe
            580                 585                 590         
Thr Pro Cys Ile Glu Thr Tyr Phe Glu Asp Glu Asp Gln Leu Asp Glu
        595                 600                 605             
Val Val Lys Tyr Leu Gln Glu Val Cys Asn Gln Ile Asp Gln Ile Met
    610                 615                 620                 
Pro Thr Trp Ile Lys Asp Asp Lys Ile Lys Phe Ile Leu
625                 630                 635         


<210> 6856
<211> 593
<212> PRT
<213> Homo sapiens

<400> 6856
Met Glu Thr Pro Pro Leu Pro Pro Ala Cys Thr Lys Gln Gly His Gln
 1               5                  10                  15      
Lys Pro Leu Asp Ser Lys Asp Asp Asn Thr Glu Lys His Cys Pro Val
            20                  25                  30          
Thr Val Asn Pro Trp His Met Lys Lys Ala Phe Lys Val Met Asn Glu
        35                  40                  45              
Leu Arg Ser Gln Asn Leu Leu Cys Asp Val Thr Ile Val Ala Glu Asp
    50                  55                  60                  
Met Glu Ile Ser Ala His Arg Val Val Leu Ala Ala Cys Ser Pro Tyr
65                  70                  75                  80  
Phe His Ala Met Phe Thr Gly Glu Met Ser Glu Ser Arg Ala Lys Arg
                85                  90                  95      
Val Arg Ile Lys Glu Val Asp Gly Trp Thr Leu Arg Met Leu Ile Asp
            100                 105                 110         
Tyr Val Tyr Thr Ala Glu Ile Gln Val Thr Glu Glu Asn Val Gln Val
        115                 120                 125             
Leu Leu Pro Ala Ala Gly Leu Leu Gln Leu Gln Asp Val Lys Lys Thr
    130                 135                 140                 
Cys Cys Glu Phe Leu Glu Ser Gln Leu His Pro Val Asn Cys Leu Gly
145                 150                 155                 160 
Ile Arg Ala Phe Ala Asp Met His Ala Cys Thr Asp Leu Leu Asn Lys
                165                 170                 175     
Ala Asn Thr Tyr Ala Glu Gln His Phe Ala Asp Val Val Leu Ser Glu
            180                 185                 190         
Glu Phe Leu Asn Leu Gly Ile Glu Gln Val Cys Ser Leu Ile Ser Ser
        195                 200                 205             
Asp Lys Leu Thr Ile Ser Ser Glu Glu Lys Val Phe Glu Ala Val Ile
    210                 215                 220                 
Ala Trp Val Asn His Asp Lys Asp Val Arg Gln Glu Phe Met Ala Arg
225                 230                 235                 240 
Leu Met Glu His Val Arg Leu Pro Leu Leu Pro Arg Glu Tyr Leu Val
                245                 250                 255     
Gln Arg Val Glu Glu Glu Ala Leu Val Lys Asn Ser Ser Ala Cys Lys
            260                 265                 270         
Asn Tyr Leu Ile Glu Ala Met Lys Tyr His Leu Leu Pro Thr Glu Gln
        275                 280                 285             
Arg Ile Leu Met Lys Ser Val Arg Thr Arg Leu Arg Thr Pro Met Asn
    290                 295                 300                 
Leu Pro Lys Leu Met Val Val Val Gly Gly Gln Ala Pro Lys Ala Ile
305                 310                 315                 320 
Arg Ser Val Glu Cys Tyr Asp Phe Lys Glu Glu Arg Trp His Gln Val
                325                 330                 335     
Ala Glu Leu Pro Ser Arg Arg Cys Arg Ala Gly Met Val Tyr Met Ala
            340                 345                 350         
Gly Leu Val Phe Ala Val Gly Gly Phe Asn Gly Ser Leu Arg Val Arg
        355                 360                 365             
Thr Val Asp Ser Tyr Asp Pro Val Lys Asp Gln Trp Thr Ser Val Ala
    370                 375                 380                 
Asn Met Arg Asp Arg Arg Ser Thr Leu Gly Ala Ala Val Leu Asn Gly
385                 390                 395                 400 
Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly Ser Thr Gly Leu Ser Ser
                405                 410                 415     
Val Glu Ala Tyr Asn Ile Lys Ser Asn Glu Trp Phe His Val Ala Pro
            420                 425                 430         
Met Asn Thr Arg Arg Ser Ser Val Gly Val Gly Val Val Gly Gly Leu
        435                 440                 445             
Leu Tyr Ala Val Gly Gly Tyr Asp Gly Ala Ser Arg Gln Tyr Leu Ser
    450                 455                 460                 
Thr Val Glu Cys Tyr Asn Ala Thr Thr Asn Glu Trp Thr Tyr Ile Ala
465                 470                 475                 480 
Glu Met Ser Thr Arg Arg Ser Gly Ala Gly Val Gly Val Leu Asn Asn
                485                 490                 495     
Leu Leu Tyr Ala Val Gly Gly His Asp Gly Pro Leu Val Arg Lys Ser
            500                 505                 510         
Val Glu Val Tyr Asp Pro Thr Thr Asn Ala Trp Arg Gln Val Ala Asp
        515                 520                 525             
Met Asn Met Cys Arg Arg Asn Ala Gly Val Cys Ala Val Asn Gly Leu
    530                 535                 540                 
Leu Tyr Val Val Gly Gly Asp Asp Gly Ser Cys Asn Leu Ala Ser Val
545                 550                 555                 560 
Glu Tyr Tyr Asn Pro Thr Thr Asp Lys Trp Thr Val Val Ser Ser Cys
                565                 570                 575     
Met Ser Thr Gly Arg Ser Tyr Ala Gly Val Thr Val Ile Asp Lys Pro
            580                 585                 590         
Leu
    


<210> 6857
<211> 593
<212> PRT
<213> Homo sapiens

<400> 6857
Met Glu Thr Pro Pro Leu Pro Pro Ala Cys Thr Lys Gln Gly His Gln
 1               5                  10                  15      
Lys Pro Leu Asp Ser Lys Asp Asp Asn Thr Glu Lys His Cys Pro Val
            20                  25                  30          
Thr Val Asn Pro Trp His Met Lys Lys Ala Phe Lys Val Met Asn Glu
        35                  40                  45              
Leu Arg Ser Gln Asn Leu Leu Cys Asp Val Thr Ile Val Ala Glu Asp
    50                  55                  60                  
Met Glu Ile Ser Ala His Arg Val Val Leu Ala Ala Cys Ser Pro Tyr
65                  70                  75                  80  
Phe His Ala Met Phe Thr Gly Glu Met Ser Glu Ser Arg Ala Lys Arg
                85                  90                  95      
Val Arg Ile Lys Glu Val Asp Gly Trp Thr Leu Arg Met Leu Ile Asp
            100                 105                 110         
Tyr Val Tyr Thr Ala Glu Ile Gln Val Thr Glu Glu Asn Val Gln Val
        115                 120                 125             
Leu Leu Pro Ala Ala Gly Leu Leu Gln Leu Gln Asp Val Lys Lys Thr
    130                 135                 140                 
Cys Cys Glu Phe Leu Glu Ser Gln Leu His Pro Val Asn Cys Leu Gly
145                 150                 155                 160 
Ile Arg Ala Phe Ala Asp Met His Ala Cys Thr Asp Leu Leu Asn Lys
                165                 170                 175     
Ala Asn Thr Tyr Ala Glu Gln His Phe Ala Asp Val Val Leu Ser Glu
            180                 185                 190         
Glu Phe Leu Asn Leu Gly Ile Glu Gln Val Cys Ser Leu Ile Ser Ser
        195                 200                 205             
Asp Lys Leu Thr Ile Ser Ser Glu Glu Lys Val Phe Glu Ala Val Ile
    210                 215                 220                 
Ala Trp Val Asn His Asp Lys Asp Val Arg Gln Glu Phe Met Ala Arg
225                 230                 235                 240 
Leu Met Glu His Val Arg Leu Pro Leu Leu Pro Arg Glu Tyr Leu Val
                245                 250                 255     
Gln Arg Val Glu Glu Glu Ala Leu Val Lys Asn Ser Ser Ala Cys Lys
            260                 265                 270         
Asp Tyr Leu Ile Glu Ala Met Lys Tyr His Leu Leu Pro Thr Glu Gln
        275                 280                 285             
Arg Ile Leu Met Lys Ser Val Arg Thr Arg Leu Arg Thr Pro Met Asn
    290                 295                 300                 
Leu Pro Lys Leu Met Val Val Val Gly Gly Gln Ala Pro Lys Ala Ile
305                 310                 315                 320 
Arg Ser Val Glu Cys Tyr Asp Phe Lys Glu Glu Arg Trp His Gln Val
                325                 330                 335     
Ala Glu Leu Pro Ser Gly Arg Cys Arg Ala Gly Met Val Tyr Met Ala
            340                 345                 350         
Gly Leu Val Phe Ala Val Gly Gly Phe Asn Gly Ser Leu Arg Val Arg
        355                 360                 365             
Thr Val Asp Ser Tyr Asp Pro Val Lys Asp Gln Trp Thr Ser Val Ala
    370                 375                 380                 
Asn Met Arg Asp Arg Arg Ser Thr Leu Gly Ala Ala Val Leu Asn Gly
385                 390                 395                 400 
Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly Ser Thr Gly Leu Ser Ser
                405                 410                 415     
Val Glu Ala Tyr Asn Ile Lys Ser Asn Glu Trp Phe His Val Ala Pro
            420                 425                 430         
Met Asn Thr Arg Arg Ser Ser Val Gly Val Gly Val Val Gly Gly Leu
        435                 440                 445             
Leu Tyr Ala Val Gly Gly Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser
    450                 455                 460                 
Thr Val Glu Cys Tyr Asn Ala Thr Thr Asn Glu Trp Thr Tyr Ile Ala
465                 470                 475                 480 
Glu Met Ser Thr Arg Arg Ser Gly Ala Gly Val Gly Val Leu Asn Asn
                485                 490                 495     
Leu Leu Tyr Ala Val Gly Gly His Asp Gly Pro Leu Val Arg Lys Ser
            500                 505                 510         
Val Glu Val Tyr Asp Pro Thr Thr Asn Ala Trp Arg Gln Val Ala Asp
        515                 520                 525             
Met Asn Met Cys Arg Arg Asn Ala Gly Val Cys Ala Val Asn Gly Leu
    530                 535                 540                 
Leu Tyr Val Val Gly Gly Asp Asp Gly Ser Cys Asn Leu Ala Ser Val
545                 550                 555                 560 
Glu Tyr Tyr Asn Pro Thr Thr Asp Lys Trp Thr Val Val Ser Ser Cys
                565                 570                 575     
Met Ser Thr Gly Arg Ser Tyr Ala Gly Val Thr Val Ile Asp Lys Pro
            580                 585                 590         
Leu
    


<210> 6858
<211> 873
<212> PRT
<213> Homo sapiens

<400> 6858
Met Thr Asp Ser Asp Glu Asp Ala Leu Lys Val Asp Gln Gly Pro Ser
 1               5                  10                  15      
Arg Asp Ile Pro Lys Pro Trp Val Ile Pro Ala Pro Lys Gly Ile Leu
            20                  25                  30          
Gln His Ile Phe Gly Thr Ser His Val Phe Gln Ser Ile Cys Asp Val
        35                  40                  45              
Lys Pro Lys Val Thr Gly Leu Thr Val Pro Leu Lys Val Arg Glu Tyr
    50                  55                  60                  
Tyr Ser Arg Gly Gln Gln Cys Leu Glu Gln Ala Asp Trp Glu Thr Ala
65                  70                  75                  80  
Val Leu Leu Phe Ser Arg Ala Leu His Leu Asp Pro Gln Leu Val Asp
                85                  90                  95      
Phe Tyr Ala Leu Arg Ala Glu Ala Tyr Leu Gln Leu Cys Asp Phe Ser
            100                 105                 110         
Ser Ala Ala Gln Asn Leu Arg Arg Ala Tyr Ser Leu Gln Gln Asp Asn
        115                 120                 125             
Cys Lys His Leu Glu Arg Leu Thr Phe Val Leu Tyr Leu Gln Gly Gln
    130                 135                 140                 
Cys Leu Phe Glu Gln Cys Ala Phe Leu Asp Ala Leu Asn Val Phe Ser
145                 150                 155                 160 
His Ala Ala Glu Leu Gln Pro Glu Lys Pro Cys Phe Arg Tyr Arg Cys
                165                 170                 175     
Met Ala Cys Leu Leu Ala Leu Lys Gln His Gln Ala Cys Leu Thr Leu
            180                 185                 190         
Ile Thr Asn Glu Leu Lys Gln Asp Thr Thr Asn Ala Asp Val Tyr Ile
        195                 200                 205             
Phe Arg Ala Arg Leu Tyr Asn Phe Leu Gln Lys Pro His Leu Cys Tyr
    210                 215                 220                 
Arg Asp Leu His Ser Ala Leu Leu Leu Asn Pro Lys His Pro Gln Ala
225                 230                 235                 240 
Arg Met Leu Leu Gln Lys Met Val Ala Gln Ala Gln Gln Ala Arg Gln
                245                 250                 255     
Asp Ala Gly Ile Leu Ala Val Gln Gly Lys Leu Gln His Ala Leu Gln
            260                 265                 270         
Arg Ile Asn Arg Ala Ile Glu Asn Asn Pro Leu Asp Pro Ser Leu Phe
        275                 280                 285             
Leu Phe Arg Gly Thr Met Tyr Arg Arg Leu Gln Glu Phe Asp Gly Ala
    290                 295                 300                 
Val Glu Asp Phe Leu Lys Val Leu Asp Met Val Thr Glu Asp Gln Glu
305                 310                 315                 320 
Asp Met Val Arg Gln Ala Gln Arg Gln Leu Leu Leu Thr Tyr Asn Asp
                325                 330                 335     
Phe Ala Val His Cys Tyr Arg Gln Gly Ala Tyr Gln Glu Gly Val Leu
            340                 345                 350         
Leu Leu Asn Lys Ala Leu Arg Asp Glu Gln Gln Glu Lys Gly Leu Tyr
        355                 360                 365             
Ile Asn Arg Gly Asp Cys Phe Phe Gln Leu Gly Asn Leu Ala Phe Ala
    370                 375                 380                 
Glu Ala Asp Tyr Gln Gln Ala Leu Ala Leu Ser Pro Gln Asp Glu Gly
385                 390                 395                 400 
Ala Asn Thr Arg Thr Gly Leu Leu Gln Glu Lys Met Gly Phe Cys Glu
                405                 410                 415     
Gln Arg Arg Lys Gln Phe Gln Lys Ala Glu Asn His Phe Ser Thr Ala
            420                 425                 430         
Ile Arg His Asn Pro Gln Lys Ala Gln Tyr Tyr Leu Tyr Arg Ala Lys
        435                 440                 445             
Ser Arg Gln Leu Leu Gln Asn Ile Phe Gly Ala Arg Gln Asp Val Ala
    450                 455                 460                 
Thr Val Leu Leu Leu Asn Pro Lys Gln Pro Lys Leu Ser Leu Leu Met
465                 470                 475                 480 
Thr Asn Leu Phe Pro Gly Met Ser Val Glu Glu Val Leu Ser Thr Gln
                485                 490                 495     
Ile Ala His Leu Ala Arg Leu Gln Leu Glu Gln Met Val Glu Gly Ser
            500                 505                 510         
Leu Gln Ala Gly Ser Pro Gln Gly Ile Val Gly Met Leu Lys Arg His
        515                 520                 525             
Glu Leu Glu Arg Gln Lys Ala Leu Ala Leu Gln His Ser Trp Lys Gln
    530                 535                 540                 
Gly Glu Pro Leu Ile Ala Thr Ser Glu Glu Leu Lys Ala Thr Pro Glu
545                 550                 555                 560 
Ile Pro Gln Val Lys Pro Gly Ser Ser Glu Gly Glu Ala Glu Ala Pro
                565                 570                 575     
Glu Glu Glu Glu Glu Lys Glu Lys Glu Lys Lys Gly Glu Lys Lys Ser
            580                 585                 590         
Glu Leu Ile Pro Ser Lys Val Ala Ser Leu Ser Asp Ser Tyr Leu Asp
        595                 600                 605             
Gln Thr Ser Ser Ala Ser Ser Met Ser Phe Arg Thr Thr Gly Thr Ser
    610                 615                 620                 
Glu Thr Glu Met Ser Ala Ile Cys Gln Glu Tyr Arg Ser Thr Ser Ala
625                 630                 635                 640 
Thr Ala Val Thr Phe Ser Asp Ser Ser Leu Leu Lys Thr Gln Ser Ser
                645                 650                 655     
Asp Ser Gly Asn Asn Arg Glu Ala Leu Ser His Gly Pro Arg Lys Ile
            660                 665                 670         
Lys Ala Thr Gln Gly Gln Arg Gln Ser Leu Ser Lys Thr Glu Pro Thr
        675                 680                 685             
Gln Ser Gln Arg Arg Asn Ser Ser Lys Thr Lys Ala Thr Ile His Lys
    690                 695                 700                 
Arg Asn Ser Ser Lys Thr Lys Ala Thr Gln Ser Gln Arg Arg Asn Ser
705                 710                 715                 720 
Ser Lys Thr Arg Ala Thr Gln Gly Gln Gly Gln Ser Ser Ser Lys Thr
                725                 730                 735     
Glu Ala Thr Gln Gly Gln Arg Gln Ser Ser Ser Glu Ile Glu Ala Thr
            740                 745                 750         
Gln Gly Pro Arg Gln Glu Pro Ser Lys Thr Lys Thr Thr Arg Ser Pro
        755                 760                 765             
Arg Gln Arg Pro Arg Lys Val Lys Ala Ala Arg Gly Arg Ser Trp Arg
    770                 775                 780                 
Pro Ser Lys Val Asp Ala Thr Gln Gly Arg Ser Arg Gly Leu Leu Arg
785                 790                 795                 800 
Ser Ser Thr Lys Thr Glu Ala Phe Tyr Asp Ser Asn Trp Ser Leu Ser
                805                 810                 815     
Lys Thr Glu Tyr Ala Gln Gly Gln Gly Gln Arg Ser Ser Lys Ala Glu
            820                 825                 830         
Gly Ala Gln Gly Lys Ser Gln Gly Met Ser Ser Thr Ser Ser Lys Ala
        835                 840                 845             
Glu Ser Thr Trp Gly Pro Ser Pro Ser Leu Ser Lys Thr Glu Val Asp
    850                 855                 860                 
Gln Asp Leu Thr Tyr Tyr Glu Ser Val
865                 870             


<210> 6859
<211> 873
<212> PRT
<213> Homo sapiens

<400> 6859
Met Thr Asp Ser Asp Glu Asp Ala Leu Lys Val Asp Gln Gly Pro Ser
 1               5                  10                  15      
Arg Asp Ile Pro Lys Pro Trp Val Ile Pro Ala Pro Lys Gly Ile Leu
            20                  25                  30          
Gln His Ile Phe Gly Thr Ser His Val Phe Gln Ser Ile Cys Asp Val
        35                  40                  45              
Lys Pro Lys Val Thr Gly Leu Thr Val Pro Leu Lys Val Arg Glu Tyr
    50                  55                  60                  
Tyr Ser Arg Gly Gln Gln Cys Leu Glu Gln Ala Asp Trp Glu Thr Ala
65                  70                  75                  80  
Val Leu Leu Phe Ser Arg Ala Leu His Leu Asp Pro Gln Leu Val Asp
                85                  90                  95      
Phe Tyr Ala Leu Arg Ala Glu Ala Tyr Leu Gln Leu Cys Asp Phe Ser
            100                 105                 110         
Ser Ala Ala Gln Asn Leu Arg Arg Ala Tyr Ser Leu Gln Gln Asp Asn
        115                 120                 125             
Cys Lys His Leu Glu Arg Leu Thr Phe Val Leu Tyr Leu Gln Gly Gln
    130                 135                 140                 
Cys Leu Phe Glu Gln Cys Ala Phe Leu Asp Ala Leu Asn Val Phe Ser
145                 150                 155                 160 
His Ala Ala Glu Leu Gln Pro Glu Lys Pro Cys Phe Arg Tyr Arg Cys
                165                 170                 175     
Met Ala Cys Leu Leu Ala Leu Lys Gln His Gln Ala Cys Leu Thr Leu
            180                 185                 190         
Ile Thr Asn Glu Leu Lys Gln Asp Thr Thr Asn Ala Asp Val Tyr Ile
        195                 200                 205             
Phe Arg Ala Arg Leu Tyr Asn Phe Leu Gln Lys Pro His Leu Cys Tyr
    210                 215                 220                 
Arg Asp Leu His Ser Ala Leu Leu Leu Asn Pro Lys His Pro Gln Ala
225                 230                 235                 240 
Arg Met Leu Leu Gln Lys Met Val Ala Gln Ala Gln Gln Ala Arg Gln
                245                 250                 255     
Asp Ala Gly Ile Leu Ala Val Gln Gly Lys Leu Gln His Ala Leu Gln
            260                 265                 270         
Arg Ile Asn Arg Ala Ile Glu Asn Asn Pro Leu Asp Pro Ser Leu Phe
        275                 280                 285             
Leu Phe Arg Gly Thr Met Tyr Arg Arg Leu Gln Glu Phe Asp Gly Ala
    290                 295                 300                 
Val Glu Asp Phe Leu Lys Val Leu Asp Met Val Thr Glu Asp Gln Glu
305                 310                 315                 320 
Asp Met Val Arg Gln Ala Gln Arg Gln Leu Leu Leu Thr Tyr Asn Asp
                325                 330                 335     
Phe Ala Val His Cys Tyr Arg Gln Gly Ala Tyr Gln Glu Gly Val Leu
            340                 345                 350         
Leu Leu Asn Lys Ala Leu Arg Asp Glu Gln Gln Glu Lys Gly Leu Tyr
        355                 360                 365             
Ile Asn Arg Gly Asp Cys Phe Phe Gln Leu Gly Asn Leu Ala Phe Ala
    370                 375                 380                 
Glu Ala Asp Tyr Gln Gln Ala Leu Ala Leu Ser Pro Gln Asp Glu Gly
385                 390                 395                 400 
Ala Asn Thr Arg Met Gly Leu Leu Gln Glu Lys Met Gly Phe Cys Glu
                405                 410                 415     
Gln Arg Arg Lys Gln Phe Gln Lys Ala Glu Asn His Phe Ser Thr Ala
            420                 425                 430         
Ile Arg His Asn Pro Gln Lys Ala Gln Tyr Tyr Leu Tyr Arg Ala Lys
        435                 440                 445             
Ser Arg Gln Leu Leu Gln Asn Ile Phe Gly Ala Arg Gln Asp Val Ala
    450                 455                 460                 
Thr Val Leu Leu Leu Asn Pro Lys Gln Pro Lys Leu Ser Leu Leu Met
465                 470                 475                 480 
Thr Asn Leu Phe Pro Gly Met Ser Val Glu Glu Val Leu Ser Thr Gln
                485                 490                 495     
Ile Ala His Leu Ala Arg Leu Gln Leu Glu Gln Met Val Glu Gly Ser
            500                 505                 510         
Leu Gln Ala Gly Ser Pro Gln Gly Ile Val Gly Met Leu Lys Arg His
        515                 520                 525             
Glu Leu Glu Arg Gln Lys Ala Leu Ala Leu Gln His Ser Trp Lys Gln
    530                 535                 540                 
Gly Glu Pro Leu Ile Ala Thr Ser Glu Glu Leu Lys Ala Thr Pro Glu
545                 550                 555                 560 
Ile Pro Gln Val Lys Pro Gly Ser Ser Glu Gly Glu Ala Glu Ala Pro
                565                 570                 575     
Glu Glu Glu Glu Glu Lys Glu Lys Glu Lys Lys Glu Glu Lys Lys Ser
            580                 585                 590         
Glu Leu Ile Pro Ser Lys Val Ala Ser Leu Ser Asp Ser Tyr Leu Asp
        595                 600                 605             
Gln Thr Ser Ser Ala Ser Ser Met Ser Phe Arg Thr Thr Gly Thr Ser
    610                 615                 620                 
Glu Thr Glu Met Ser Ala Ile Cys Gln Glu Tyr Arg Ser Thr Ser Ala
625                 630                 635                 640 
Thr Ala Val Thr Phe Ser Asp Ser Ser Leu Leu Lys Thr Gln Ser Ser
                645                 650                 655     
Asp Ser Gly Asn Asn Arg Glu Ala Leu Ser His Gly Pro Arg Lys Ile
            660                 665                 670         
Lys Ala Thr Gln Gly Gln Arg Gln Ser Leu Ser Lys Thr Glu Pro Thr
        675                 680                 685             
Gln Ser Gln Arg Arg Asn Ser Ser Lys Thr Lys Ala Thr Ile His Lys
    690                 695                 700                 
Arg Asn Ser Ser Lys Thr Lys Ala Thr Gln Ser Gln Arg Arg Asn Ser
705                 710                 715                 720 
Ser Lys Thr Arg Ala Thr Gln Gly Gln Gly Gln Ser Ser Ser Lys Thr
                725                 730                 735     
Glu Ala Thr Gln Gly Gln Arg Gln Ser Ser Ser Glu Ile Glu Ala Thr
            740                 745                 750         
Gln Gly Pro Arg Gln Glu Pro Ser Lys Thr Lys Thr Thr Arg Ser Pro
        755                 760                 765             
Arg Gln Arg Pro Arg Lys Val Lys Ala Ala Arg Gly Arg Ser Trp Arg
    770                 775                 780                 
Pro Ser Lys Val Asp Ala Thr Gln Gly Arg Ser Arg Gly Leu Leu Arg
785                 790                 795                 800 
Ser Ser Thr Lys Thr Glu Ala Phe Tyr Asp Ser Asn Trp Ser Leu Ser
                805                 810                 815     
Lys Thr Glu Tyr Ala Gln Gly Gln Gly Gln Arg Ser Ser Lys Ala Glu
            820                 825                 830         
Gly Ala Gln Gly Lys Ser Gln Gly Met Ser Ser Thr Ser Ser Lys Ala
        835                 840                 845             
Glu Ser Thr Trp Gly Pro Ser Pro Ser Leu Ser Lys Thr Glu Val Asp
    850                 855                 860                 
Gln Asp Leu Thr Tyr Tyr Glu Ala Val
865                 870             


<210> 6860
<211> 814
<212> PRT
<213> Homo sapiens

<400> 6860
Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala
 1               5                  10                  15      
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp
            20                  25                  30          
Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile
        35                  40                  45              
Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val
    50                  55                  60                  
Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile
65                  70                  75                  80  
Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn
                85                  90                  95      
Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe
            100                 105                 110         
Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr
        115                 120                 125             
Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val
    130                 135                 140                 
Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala
145                 150                 155                 160 
Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala
                165                 170                 175     
Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp
            180                 185                 190         
Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe
        195                 200                 205             
Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly
    210                 215                 220                 
Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu
225                 230                 235                 240 
Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala
                245                 250                 255     
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys
            260                 265                 270         
Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile
        275                 280                 285             
Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser
    290                 295                 300                 
Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro
305                 310                 315                 320 
Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser
                325                 330                 335     
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu
            340                 345                 350         
Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala
        355                 360                 365             
Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser
    370                 375                 380                 
Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe
385                 390                 395                 400 
Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val
                405                 410                 415     
His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu
            420                 425                 430         
Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp
        435                 440                 445             
Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val
    450                 455                 460                 
Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val
465                 470                 475                 480 
Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser
                485                 490                 495     
Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala
            500                 505                 510         
Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp
        515                 520                 525             
Ala Asn Glu Lys Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys
    530                 535                 540                 
Ile Lys Val Val Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp
545                 550                 555                 560 
Gln Leu Gly Lys Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys
                565                 570                 575     
Met Ile Met Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn
            580                 585                 590         
Ala Val Glu Glu Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro
        595                 600                 605             
Tyr Glu Lys Phe Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu
    610                 615                 620                 
Leu Thr Glu Thr Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala
625                 630                 635                 640 
Lys Gln Ala Tyr Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr
                645                 650                 655     
Pro Val Lys Val Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe
            660                 665                 670         
Glu Glu Leu Gly Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp
        675                 680                 685             
Phe Arg Asn Lys Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met
    690                 695                 700                 
Lys Lys Val Glu Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn
705                 710                 715                 720 
Val Met Asn Ala Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val
                725                 730                 735     
Arg Ala Gln Glu Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys
            740                 745                 750         
Glu Pro Val Val Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu
        755                 760                 765             
Glu Arg Thr Pro Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu
    770                 775                 780                 
Glu Asp Lys Asn Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu
785                 790                 795                 800 
Cys Tyr Pro Asn Glu Lys Asn Ser Val Asn Met Asp Leu Asp
                805                 810                 


<210> 6861
<211> 858
<212> PRT
<213> Homo sapiens

<400> 6861
Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala
 1               5                  10                  15      
Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp
            20                  25                  30          
Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile
        35                  40                  45              
Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val
    50                  55                  60                  
Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile
65                  70                  75                  80  
Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn
                85                  90                  95      
Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe
            100                 105                 110         
Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr
        115                 120                 125             
Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val
    130                 135                 140                 
Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala
145                 150                 155                 160 
Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala
                165                 170                 175     
Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp
            180                 185                 190         
Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe
        195                 200                 205             
Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly
    210                 215                 220                 
Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu
225                 230                 235                 240 
Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala
                245                 250                 255     
Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys
            260                 265                 270         
Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile
        275                 280                 285             
Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser
    290                 295                 300                 
Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro
305                 310                 315                 320 
Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser
                325                 330                 335     
Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu
            340                 345                 350         
Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala
        355                 360                 365             
Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser
    370                 375                 380                 
Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe
385                 390                 395                 400 
Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val
                405                 410                 415     
His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu
            420                 425                 430         
Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp
        435                 440                 445             
Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val
    450                 455                 460                 
Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val
465                 470                 475                 480 
Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser
                485                 490                 495     
Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala
            500                 505                 510         
Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp
        515                 520                 525             
Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val
    530                 535                 540                 
Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu
545                 550                 555                 560 
Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys
                565                 570                 575     
Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val
            580                 585                 590         
Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys
        595                 600                 605             
Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln
    610                 615                 620                 
Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu
625                 630                 635                 640 
Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe
                645                 650                 655     
Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr
            660                 665                 670         
Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr
        675                 680                 685             
Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val
    690                 695                 700                 
Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly
705                 710                 715                 720 
Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys
                725                 730                 735     
Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu
            740                 745                 750         
Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala
        755                 760                 765             
Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu
    770                 775                 780                 
Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val
785                 790                 795                 800 
Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro
                805                 810                 815     
Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn
            820                 825                 830         
Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn
        835                 840                 845             
Glu Lys Asn Ser Val Asn Met Asp Leu Asp
    850                 855             


<210> 6862
<211> 1684
<212> PRT
<213> Homo sapiens

<400> 6862
Gln Leu Arg Lys Leu Val Leu Glu Ile Ile His Arg Ile Pro Thr Asn
 1               5                  10                  15      
Glu His Leu Arg Pro His Thr Lys Asn Val Leu Ser Val Met Phe Arg
            20                  25                  30          
Phe Leu Glu Thr Glu Asn Glu Glu Asn Val Leu Ile Cys Leu Arg Ile
        35                  40                  45              
Ile Ile Glu Leu His Lys Gln Phe Arg Pro Pro Ile Thr Gln Glu His
    50                  55                  60                  
Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val Leu Ala Glu Leu
65                  70                  75                  80  
Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys Leu Asn Ile His
                85                  90                  95      
Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn Thr Ile Ala Ile
            100                 105                 110         
Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr Asn Lys Glu Leu
        115                 120                 125             
Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu Ser Phe Leu Ala
    130                 135                 140                 
Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys Tyr Ser Gln Gln
145                 150                 155                 160 
Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys Pro Ala Glu Thr
                165                 170                 175     
Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys His Ile Leu Thr
            180                 185                 190         
Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp Lys Leu Phe Asp
        195                 200                 205             
Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg Glu Thr Leu Arg
    210                 215                 220                 
Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His His Val Arg Gln
225                 230                 235                 240 
His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln Leu Phe Ala Lys
                245                 250                 255     
Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln Thr Met Ser Cys
            260                 265                 270         
Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser Lys Ser Glu Gln
        275                 280                 285             
Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met Leu Glu Val Phe
    290                 295                 300                 
Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu Ser Ala Ile Phe
305                 310                 315                 320 
Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val Glu Ala Ala Leu
                325                 330                 335     
Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro Ala Pro Ser Pro
            340                 345                 350         
Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala
        355                 360                 365             
Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu Lys Gln Gly Glu
    370                 375                 380                 
Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr Asp Cys Arg Ser
385                 390                 395                 400 
Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile Thr Trp Gly Ile
                405                 410                 415     
Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile Pro Asn Lys Gln
            420                 425                 430         
Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu Val Lys Tyr Ala
        435                 440                 445             
Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala Gly Asn Gly Gln
    450                 455                 460                 
Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg Met Lys Glu Glu
465                 470                 475                 480 
Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr Met Met Asn Pro
                485                 490                 495     
Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro Tyr Met Val Glu
            500                 505                 510         
Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala Asn Ser Phe Leu
        515                 520                 525             
Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile Leu Val Glu Tyr
    530                 535                 540                 
Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val Glu Leu Ser Asn
545                 550                 555                 560 
Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser Val Ser Leu Phe
                565                 570                 575     
Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu His Lys Ile Val
            580                 585                 590         
Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu Pro Tyr Asn Tyr
        595                 600                 605             
Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly Gly Gly Leu Asn
    610                 615                 620                 
Met Leu Gln Ser Gly Leu His Lys Gln His Met Lys Asp Leu Phe Val
625                 630                 635                 640 
Glu Leu Cys Leu Thr Val Pro Val Arg Leu Ser Ser Leu Leu Pro Tyr
                645                 650                 655     
Leu Pro Met Leu Met Asp Pro Leu Val Ser Ala Leu Asn Gly Ser Gln
            660                 665                 670         
Thr Leu Val Ser Gln Gly Leu Arg Thr Leu Glu Leu Cys Val Asp Asn
        675                 680                 685             
Leu Gln Pro Asp Phe Leu Tyr Asp His Ile Gln Pro Val Arg Ala Glu
    690                 695                 700                 
Leu Met Gln Ala Leu Trp Arg Thr Leu Arg Asn Pro Ala Asp Ser Ile
705                 710                 715                 720 
Ser His Val Ala Tyr Arg Val Leu Gly Lys Phe Gly Gly Ser Asn Arg
                725                 730                 735     
Lys Met Leu Lys Glu Ser Gln Lys Leu His Tyr Val Val Thr Glu Val
            740                 745                 750         
Gln Gly Pro Ser Ile Thr Val Glu Phe Ser Asp Cys Lys Ala Ser Leu
        755                 760                 765             
Gln Leu Pro Met Glu Lys Ala Ile Glu Thr Ala Leu Asp Cys Leu Lys
    770                 775                 780                 
Ser Ala Asn Thr Glu Pro Tyr Tyr Arg Arg Gln Ala Trp Glu Val Ile
785                 790                 795                 800 
Lys Cys Phe Leu Val Ala Met Met Ser Leu Glu Asp Asn Lys His Ala
                805                 810                 815     
Leu Tyr Gln Leu Leu Ala His Pro Asn Phe Thr Glu Lys Thr Ile Pro
            820                 825                 830         
Asn Val Ile Ile Ser His Arg Tyr Lys Ala Gln Asp Thr Pro Ala Arg
        835                 840                 845             
Lys Thr Phe Glu Gln Ala Leu Thr Gly Ala Phe Met Ser Ala Val Ile
    850                 855                 860                 
Lys Asp Leu Arg Pro Ser Ala Leu Pro Phe Val Ala Ser Leu Ile Arg
865                 870                 875                 880 
His Tyr Thr Met Val Ala Val Ala Gln Gln Cys Gly Pro Phe Leu Leu
                885                 890                 895     
Pro Cys Tyr Gln Val Gly Ser Gln Pro Ser Thr Ala Met Phe His Ser
            900                 905                 910         
Glu Glu Asn Gly Ser Lys Gly Met Asp Pro Leu Val Leu Ile Asp Ala
        915                 920                 925             
Ile Ala Ile Cys Met Ala Tyr Glu Glu Lys Glu Leu Cys Lys Ile Gly
    930                 935                 940                 
Glu Val Ala Leu Ala Val Ile Phe Asp Val Ala Ser Ile Ile Leu Gly
945                 950                 955                 960 
Ser Lys Glu Arg Ala Cys Gln Leu Pro Leu Phe Ser Tyr Ile Val Glu
                965                 970                 975     
Arg Leu Cys Ala Cys Cys Tyr Glu Gln Ala Trp Tyr Ala Lys Leu Gly
            980                 985                 990         
Gly Val Val Ser Ile Lys Phe Leu Met Glu Arg Leu Pro Leu Thr Trp
        995                 1000                1005            
Val Leu Gln Asn Gln Gln Thr Phe Leu Lys Ala Leu Leu Phe Val Met
    1010                1015                1020                
Met Asp Leu Thr Gly Glu Val Ser Asn Gly Ala Val Ala Met Ala Lys
1025                1030                1035                1040
Thr Thr Leu Glu Gln Leu Leu Met Arg Cys Ala Thr Pro Leu Lys Asp
                1045                1050                1055    
Glu Glu Arg Ala Glu Glu Ile Val Ala Ala Gln Glu Lys Ser Phe His
            1060                1065                1070        
His Val Thr His Asp Leu Val Arg Glu Val Thr Ser Pro Asn Ser Thr
        1075                1080                1085            
Val Arg Lys Gln Ala Met His Ser Leu Gln Val Leu Ala Gln Val Thr
    1090                1095                1100                
Gly Lys Ser Val Thr Val Ile Met Glu Pro His Lys Glu Phe Leu Glu
1105                1110                1115                1120
Gly Ala Thr Ile Glu Val Asp Gln Ile His Thr His Met Arg Pro Leu
                1125                1130                1135    
Leu Met Met Leu Gly Asp Tyr Arg Ser Leu Thr Leu Asn Val Val Asn
            1140                1145                1150        
Arg Leu Thr Ser Val Thr Arg Leu Phe Pro Asn Ser Phe Asn Asp Lys
        1155                1160                1165            
Phe Cys Asp Gln Met Met Glu Met Lys Ile Cys Ser Ala Ile Ile Asn
    1170                1175                1180                
Leu Phe His Leu Ile Pro Ala Ala Pro Gln Thr Leu Val Lys Pro Leu
1185                1190                1195                1200
Leu Glu Val Val Met Lys Thr Glu Arg Ala Met Leu Ile Glu Ala Gly
                1205                1210                1215    
Ser Pro Phe Arg Glu Pro Leu Ile Lys Phe Leu Thr Arg His Pro Ser
            1220                1225                1230        
Gln Thr Val Glu Leu Phe Met Met Glu Ala Thr Leu Asn Asp Pro Gln
        1235                1240                1245            
Trp Ser Arg Met Phe Met Ser Phe Leu Lys His Lys Asp Ala Arg Pro
    1250                1255                1260                
Leu Arg Asp Val Leu Ala Ala Asn Pro Asn Arg Phe Ile Thr Leu Leu
1265                1270                1275                1280
Leu Pro Gly Gly Ala Gln Thr Ala Val Arg Pro Gly Ser Pro Ser Thr
                1285                1290                1295    
Ser Thr Met Arg Leu Asp Leu Gln Phe Gln Ala Ile Lys Ile Ile Ser
            1300                1305                1310        
Ile Ile Val Lys Asn Asp Asp Ser Trp Leu Ala Ser Gln His Ser Leu
        1315                1320                1325            
Val Ser Gln Leu Arg Arg Val Trp Val Ser Glu Asn Phe Gln Glu Arg
    1330                1335                1340                
His Arg Lys Glu Asn Met Ala Ala Thr Asn Trp Lys Glu Pro Lys Leu
1345                1350                1355                1360
Leu Ala Tyr Cys Leu Leu Asn Tyr Cys Lys Arg Asn Tyr Gly Asp Ile
                1365                1370                1375    
Glu Leu Leu Phe Gln Leu Leu Arg Ala Phe Thr Gly Arg Phe Leu Cys
            1380                1385                1390        
Asn Met Thr Phe Leu Lys Glu Tyr Met Glu Glu Glu Ile Pro Lys Asn
        1395                1400                1405            
Tyr Ser Ile Ala Gln Lys Arg Ala Leu Phe Phe Arg Phe Val Asp Phe
    1410                1415                1420                
Asn Asp Pro Asn Phe Gly Asp Glu Leu Lys Ala Lys Val Leu Asp Pro
1425                1430                1435                1440
Glu Lys Gln Ala Asp Met Leu Asp Ser Leu Arg Ile Tyr Leu Leu Gln
                1445                1450                1455    
Tyr Ala Thr Leu Leu Val Glu His Ala Pro His His Ile His Asp Asn
            1460                1465                1470        
Asn Lys Asn Arg Asn Ser Lys Leu Arg Arg Leu Met Thr Phe Ala Trp
        1475                1480                1485            
Pro Cys Leu Leu Ser Lys Ala Cys Val Asp Pro Ala Cys Lys Tyr Ser
    1490                1495                1500                
Gly His Leu Leu Leu Ala His Ile Ile Ala Lys Phe Ala Ile His Lys
1505                1510                1515                1520
Lys Ile Val Leu Gln Val Phe His Ser Leu Leu Lys Ala His Ala Met
                1525                1530                1535    
Glu Ala Arg Ala Ile Val Arg Gln Ala Met Ala Ile Leu Thr Pro Ala
            1540                1545                1550        
Val Pro Ala Arg Met Glu Asp Gly His Gln Met Leu Thr His Trp Thr
        1555                1560                1565            
Arg Lys Ile Ile Val Glu Glu Gly His Thr Val Pro Gln Leu Val His
    1570                1575                1580                
Ile Leu His Leu Ile Val Gln His Phe Lys Val Tyr Tyr Pro Val Arg
1585                1590                1595                1600
His His Leu Val Gln His Met Val Ser Ala Met Gln Arg Leu Gly Phe
                1605                1610                1615    
Thr Pro Ser Val Thr Ile Glu Gln Arg Arg Leu Ala Val Asp Leu Ser
            1620                1625                1630        
Glu Val Val Ile Lys Trp Glu Leu Gln Arg Ile Lys Asp Gln Gln Val
        1635                1640                1645            
Phe Gly Arg Ser Gln Ser Leu Pro Gly Ala Asp Ser Leu Leu Ala Lys
    1650                1655                1660                
Pro Ile Asp Lys Gln His Thr Asp Thr Val Val Asn Phe Leu Ile Arg
1665                1670                1675                1680
Val Ala Cys Gln
                


<210> 6863
<211> 1683
<212> PRT
<213> Homo sapiens

<400> 6863
Met Asn Gln Asn Thr Thr Glu Pro Val Ala Ala Thr Glu Thr Leu Ala
 1               5                  10                  15      
Glu Val Pro Glu His Val Leu Arg Gly Leu Pro Glu Glu Val Arg Leu
            20                  25                  30          
Phe Pro Ser Ala Val Asp Lys Thr Arg Ile Gly Val Trp Ala Thr Lys
        35                  40                  45              
Pro Ile Leu Lys Gly Lys Lys Phe Gly Pro Phe Val Gly Asp Lys Lys
    50                  55                  60                  
Lys Arg Ser Gln Val Lys Asn Asn Val Tyr Met Trp Glu Val Tyr Tyr
65                  70                  75                  80  
Pro Asn Leu Gly Trp Met Cys Ile Asp Ala Thr Asp Pro Glu Lys Gly
                85                  90                  95      
Asn Trp Leu Arg Tyr Val Asn Trp Ala Cys Ser Gly Glu Glu Gln Asn
            100                 105                 110         
Leu Phe Pro Leu Glu Ile Asn Arg Ala Ile Tyr Tyr Lys Thr Leu Lys
        115                 120                 125             
Pro Ile Ala Pro Gly Glu Glu Leu Leu Val Trp Tyr Asn Gly Glu Asp
    130                 135                 140                 
Asn Pro Glu Ile Ala Ala Ala Ile Glu Glu Glu Arg Ala Ser Ala Arg
145                 150                 155                 160 
Ser Lys Arg Ser Ser Pro Lys Ser Arg Lys Gly Lys Lys Lys Ser Gln
                165                 170                 175     
Glu Asn Lys Asn Lys Gly Asn Lys Ile Gln Asp Ile Gln Leu Lys Thr
            180                 185                 190         
Ser Glu Pro Asp Phe Thr Ser Ala Asn Met Arg Asp Ser Ala Glu Gly
        195                 200                 205             
Pro Lys Glu Asp Glu Glu Lys Pro Ser Ala Ser Ala Leu Glu Gln Pro
    210                 215                 220                 
Ala Thr Leu Gln Glu Val Ala Ser Gln Glu Val Pro Pro Glu Leu Ala
225                 230                 235                 240 
Thr Pro Ala Pro Ala Trp Glu Pro Gln Pro Glu Pro Asp Glu Arg Leu
                245                 250                 255     
Glu Ala Ala Ala Cys Glu Val Asn Asp Leu Gly Glu Glu Glu Glu Glu
            260                 265                 270         
Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp Glu
        275                 280                 285             
Leu Glu Asp Glu Gly Glu Glu Glu Ala Ser Met Pro Asn Glu Asn Ser
    290                 295                 300                 
Val Lys Glu Pro Glu Ile Arg Cys Asp Glu Lys Pro Glu Asp Leu Leu
305                 310                 315                 320 
Glu Glu Pro Lys Thr Thr Ser Glu Glu Thr Leu Glu Asp Cys Ser Glu
                325                 330                 335     
Val Thr Pro Ala Met Gln Ile Pro Arg Thr Lys Glu Glu Ala Asn Gly
            340                 345                 350         
Asp Val Phe Glu Thr Phe Met Phe Pro Cys Gln His Cys Glu Arg Lys
        355                 360                 365             
Phe Thr Thr Lys Gln Gly Leu Glu Arg His Met His Ile His Ile Ser
    370                 375                 380                 
Thr Val Asn His Ala Phe Lys Cys Lys Tyr Cys Gly Lys Ala Phe Gly
385                 390                 395                 400 
Thr Gln Ile Asn Arg Arg Arg His Glu Arg Arg His Glu Ala Gly Leu
                405                 410                 415     
Lys Arg Lys Pro Ser Gln Thr Leu Gln Pro Ser Glu Asp Leu Ala Asp
            420                 425                 430         
Gly Lys Ala Ser Gly Glu Asn Val Ala Ser Lys Asp Asp Ser Ser Pro
        435                 440                 445             
Pro Ser Leu Gly Pro Asp Cys Leu Ile Met Asn Ser Glu Lys Ala Ser
    450                 455                 460                 
Gln Asp Thr Ile Asn Ser Ser Val Val Glu Glu Asn Gly Glu Val Lys
465                 470                 475                 480 
Glu Leu His Pro Cys Lys Tyr Cys Lys Lys Val Phe Gly Thr His Thr
                485                 490                 495     
Asn Met Arg Arg His Gln Arg Arg Val His Glu Arg His Leu Ile Pro
            500                 505                 510         
Lys Gly Val Arg Arg Lys Gly Gly Leu Glu Glu Pro Gln Pro Pro Ala
        515                 520                 525             
Glu Gln Ala Gln Ala Thr Gln Asn Val Tyr Val Pro Ser Thr Glu Pro
    530                 535                 540                 
Glu Glu Glu Gly Glu Ala Asp Asp Val Tyr Ile Met Asp Ile Ser Ser
545                 550                 555                 560 
Asn Ile Ser Glu Asn Leu Asn Tyr Tyr Ile Asp Gly Lys Ile Gln Thr
                565                 570                 575     
Asn Asn Asn Thr Ser Asn Cys Asp Val Ile Glu Met Glu Ser Ala Ser
            580                 585                 590         
Ala Asp Leu Tyr Gly Ile Asn Cys Leu Leu Thr Pro Val Thr Val Glu
        595                 600                 605             
Ile Thr Gln Asn Ile Lys Thr Thr Gln Val Pro Val Thr Glu Asp Leu
    610                 615                 620                 
Pro Lys Glu Pro Leu Gly Ser Thr Asn Ser Glu Ala Lys Lys Arg Arg
625                 630                 635                 640 
Thr Ala Ser Pro Pro Ala Leu Pro Lys Ile Lys Ala Glu Thr Asp Ser
                645                 650                 655     
Asp Pro Met Val Pro Ser Cys Ser Leu Ser Leu Pro Leu Ser Ile Ser
            660                 665                 670         
Thr Thr Glu Ala Val Ser Phe His Lys Glu Lys Ser Val Tyr Leu Ser
        675                 680                 685             
Ser Lys Leu Lys Gln Leu Leu Gln Thr Gln Asp Lys Leu Thr Pro Pro
    690                 695                 700                 
Ala Gly Ile Ser Ala Thr Glu Ile Ala Lys Leu Gly Pro Val Cys Val
705                 710                 715                 720 
Ser Ala Pro Ala Ser Met Leu Pro Val Thr Ser Ser Arg Phe Lys Arg
                725                 730                 735     
Arg Thr Ser Ser Pro Pro Ser Ser Pro Gln His Ser Pro Ala Leu Arg
            740                 745                 750         
Asp Phe Gly Lys Pro Ser Asp Gly Lys Ala Ala Trp Thr Asp Ala Gly
        755                 760                 765             
Leu Thr Ser Lys Lys Ser Lys Leu Glu Ser His Ser Asp Ser Pro Ala
    770                 775                 780                 
Trp Ser Leu Ser Gly Arg Asp Glu Arg Glu Thr Val Ser Pro Pro Cys
785                 790                 795                 800 
Phe Asp Glu Tyr Lys Met Ser Lys Glu Trp Thr Ala Ser Ser Ala Phe
                805                 810                 815     
Ser Ser Val Cys Asn Gln Gln Pro Leu Asp Leu Ser Ser Gly Val Lys
            820                 825                 830         
Gln Lys Ala Glu Gly Thr Gly Lys Thr Pro Val Gln Trp Glu Ser Val
        835                 840                 845             
Leu Asp Leu Ser Val His Lys Lys His Cys Ser Asp Ser Glu Gly Lys
    850                 855                 860                 
Glu Phe Lys Glu Ser His Ser Val Gln Pro Thr Cys Ser Ala Val Lys
865                 870                 875                 880 
Lys Arg Lys Pro Thr Thr Cys Met Leu Gln Lys Val Leu Leu Asn Glu
                885                 890                 895     
Tyr Asn Gly Ile Asp Leu Pro Val Glu Asn Pro Ala Asp Gly Thr Arg
            900                 905                 910         
Ser Pro Ser Pro Cys Lys Ser Leu Glu Ala Gln Pro Asp Pro Asp Leu
        915                 920                 925             
Gly Pro Gly Ser Gly Phe Pro Ala Pro Thr Val Glu Ser Thr Pro Asp
    930                 935                 940                 
Val Cys Pro Ser Ser Pro Ala Leu Gln Thr Pro Ser Leu Ser Ser Gly
945                 950                 955                 960 
Gln Leu Pro Pro Leu Leu Ile Pro Thr Asp Pro Ser Ser Pro Pro Pro
                965                 970                 975     
Cys Pro Pro Val Leu Thr Val Ala Thr Pro Pro Pro Pro Leu Leu Pro
            980                 985                 990         
Thr Val Pro Leu Pro Ala Pro Ser Ser Ser Ala Ser Pro His Pro Cys
        995                 1000                1005            
Pro Ser Pro Leu Ser Asn Ala Thr Ala Gln Ser Pro Leu Pro Ile Leu
    1010                1015                1020                
Ser Pro Thr Val Ser Pro Ser Pro Ser Pro Ile Pro Pro Val Glu Pro
1025                1030                1035                1040
Leu Met Ser Ala Ala Ser Pro Gly Pro Pro Thr Leu Ser Ser Ser Ser
                1045                1050                1055    
Ser Ser Ser Ser Ser Ser Ser Ser Phe Ser Ser Ser Ser Ser Ser Ser
            1060                1065                1070        
Ser Pro Ser Pro Pro Pro Leu Ser Ala Ile Ser Ser Val Val Ser Ser
        1075                1080                1085            
Gly Asp Asn Leu Glu Ala Ser Leu Pro Met Ile Ser Phe Lys Gln Glu
    1090                1095                1100                
Glu Leu Glu Asn Glu Gly Leu Lys Pro Arg Glu Glu Pro Gln Ser Ala
1105                1110                1115                1120
Ala Glu Gln Asp Val Val Val Gln Glu Thr Phe Asn Lys Asn Phe Val
                1125                1130                1135    
Cys Asn Val Cys Glu Ser Pro Phe Leu Ser Ile Lys Asp Leu Thr Lys
            1140                1145                1150        
His Leu Ser Ile His Ala Glu Glu Trp Pro Phe Lys Cys Glu Phe Cys
        1155                1160                1165            
Val Gln Leu Phe Lys Asp Lys Thr Asp Leu Ser Glu His Arg Phe Leu
    1170                1175                1180                
Leu His Gly Val Gly Asn Ile Phe Val Cys Ser Val Cys Lys Lys Glu
1185                1190                1195                1200
Phe Ala Phe Leu Cys Asn Leu Gln Gln His Gln Arg Asp Leu His Pro
                1205                1210                1215    
Asp Lys Val Cys Thr His His Glu Phe Glu Ser Gly Thr Leu Arg Pro
            1220                1225                1230        
Gln Asn Phe Thr Asp Pro Ser Lys Ala His Val Glu His Met Gln Ser
        1235                1240                1245            
Leu Pro Glu Asp Pro Leu Glu Thr Ser Lys Glu Glu Glu Glu Leu Asn
    1250                1255                1260                
Asp Ser Ser Glu Glu Leu Tyr Thr Thr Ile Lys Ile Met Ala Ser Gly
1265                1270                1275                1280
Ile Lys Thr Lys Asp Pro Asp Val Arg Leu Gly Leu Asn Gln His Tyr
                1285                1290                1295    
Pro Ser Phe Lys Pro Pro Pro Phe Gln Tyr His His Arg Asn Pro Met
            1300                1305                1310        
Gly Ile Gly Val Thr Ala Thr Asn Phe Thr Thr His Asn Ile Pro Gln
        1315                1320                1325            
Thr Phe Thr Thr Ala Ile Arg Cys Thr Lys Cys Gly Lys Gly Val Asp
    1330                1335                1340                
Asn Met Pro Glu Leu His Lys His Ile Leu Ala Cys Ala Ser Ala Ser
1345                1350                1355                1360
Asp Lys Lys Arg Tyr Thr Pro Lys Lys Asn Pro Val Pro Leu Lys Gln
                1365                1370                1375    
Thr Val Gln Pro Lys Asn Gly Val Val Val Leu Asp Asn Ser Gly Lys
            1380                1385                1390        
Asn Ala Phe Arg Arg Met Gly Gln Pro Lys Arg Leu Asn Phe Ser Val
        1395                1400                1405            
Glu Leu Ser Lys Met Ser Ser Asn Lys Leu Lys Leu Asn Ala Leu Lys
    1410                1415                1420                
Lys Lys Asn Gln Leu Val Gln Lys Ala Ile Leu Gln Lys Asn Lys Ser
1425                1430                1435                1440
Ala Lys Gln Lys Ala Asp Leu Lys Asn Ala Cys Glu Ser Ser Ser His
                1445                1450                1455    
Ile Cys Pro Tyr Cys Asn Arg Glu Phe Thr Tyr Ile Gly Ser Leu Asn
            1460                1465                1470        
Lys His Ala Ala Phe Ser Cys Pro Lys Lys Pro Leu Ser Pro Pro Lys
        1475                1480                1485            
Lys Lys Val Ser His Ser Ser Lys Lys Gly Gly His Ser Ser Pro Ala
    1490                1495                1500                
Ser Ser Asp Lys Asn Ser Asn Ser Asn His Arg Arg Arg Thr Ala Asp
1505                1510                1515                1520
Ala Glu Ile Lys Met Gln Ser Met Gln Thr Pro Leu Gly Lys Thr Arg
                1525                1530                1535    
Ala Arg Ser Ser Gly Pro Thr Gln Val Pro Leu Pro Ser Ser Ser Phe
            1540                1545                1550        
Arg Ser Lys Gln Asn Val Lys Phe Ala Ala Ser Val Lys Ser Lys Lys
        1555                1560                1565            
Pro Ser Ser Ser Ser Leu Arg Asn Ser Ser Pro Ile Arg Met Ala Lys
    1570                1575                1580                
Ile Thr His Val Glu Gly Lys Lys Pro Lys Ala Val Ala Lys Asn His
1585                1590                1595                1600
Ser Ala Gln Leu Ser Ser Lys Thr Ser Arg Ser Leu His Val Arg Val
                1605                1610                1615    
Gln Lys Ser Lys Ala Val Leu Gln Ser Lys Ser Thr Leu Ala Ser Lys
            1620                1625                1630        
Lys Arg Thr Asp Arg Phe Asn Ile Lys Ser Arg Glu Arg Ser Gly Gly
        1635                1640                1645            
Pro Val Thr Arg Ser Leu Gln Leu Ala Ala Ala Ala Asp Leu Ser Glu
    1650                1655                1660                
Asn Lys Arg Glu Asp Gly Ser Ala Lys Gln Glu Leu Lys Asp Phe Arg
1665                1670                1675                1680
Asn Phe Leu
            


<210> 6864
<211> 1719
<212> PRT
<213> Homo sapiens

<400> 6864
Met Asn Gln Asn Thr Thr Glu Pro Val Ala Ala Thr Glu Thr Leu Ala
 1               5                  10                  15      
Glu Val Pro Glu His Val Leu Arg Gly Leu Pro Glu Glu Val Arg Leu
            20                  25                  30          
Phe Pro Ser Ala Val Asp Lys Thr Arg Ile Gly Val Trp Ala Thr Lys
        35                  40                  45              
Pro Ile Leu Lys Gly Lys Lys Phe Gly Pro Phe Val Gly Asp Lys Lys
    50                  55                  60                  
Lys Arg Ser Gln Val Lys Asn Asn Val Tyr Met Trp Glu Val Tyr Tyr
65                  70                  75                  80  
Pro Asn Leu Gly Trp Met Cys Ile Asp Ala Thr Asp Pro Glu Lys Gly
                85                  90                  95      
Asn Trp Leu Arg Tyr Val Asn Trp Ala Cys Ser Gly Glu Glu Gln Asn
            100                 105                 110         
Leu Phe Pro Leu Glu Ile Asn Arg Ala Ile Tyr Tyr Lys Thr Leu Lys
        115                 120                 125             
Pro Ile Ala Pro Gly Glu Glu Leu Leu Val Trp Tyr Asn Gly Glu Asp
    130                 135                 140                 
Asn Pro Glu Ile Ala Ala Ala Ile Glu Glu Glu Arg Ala Ser Ala Arg
145                 150                 155                 160 
Ser Lys Arg Ser Ser Pro Lys Ser Arg Lys Gly Lys Lys Lys Ser Gln
                165                 170                 175     
Glu Asn Lys Asn Lys Gly Asn Lys Ile Gln Asp Ile Gln Leu Lys Thr
            180                 185                 190         
Ser Glu Pro Asp Phe Thr Ser Ala Asn Met Arg Asp Ser Ala Glu Gly
        195                 200                 205             
Pro Lys Glu Asp Glu Glu Lys Pro Ser Ala Ser Ala Leu Glu Gln Pro
    210                 215                 220                 
Ala Thr Leu Gln Glu Val Ala Ser Gln Glu Val Pro Pro Glu Leu Ala
225                 230                 235                 240 
Thr Pro Ala Pro Ala Trp Glu Pro Gln Pro Glu Pro Asp Glu Arg Leu
                245                 250                 255     
Glu Ala Ala Ala Cys Glu Val Asn Asp Leu Gly Glu Glu Glu Glu Glu
            260                 265                 270         
Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp Glu
        275                 280                 285             
Leu Glu Asp Glu Gly Glu Glu Glu Ala Ser Met Pro Asn Glu Asn Ser
    290                 295                 300                 
Val Lys Glu Pro Glu Ile Arg Cys Asp Glu Lys Pro Glu Asp Leu Leu
305                 310                 315                 320 
Glu Glu Pro Lys Thr Thr Ser Glu Glu Thr Leu Glu Asp Cys Ser Glu
                325                 330                 335     
Val Thr Pro Ala Met Gln Ile Pro Arg Thr Lys Glu Glu Ala Asn Gly
            340                 345                 350         
Asp Val Phe Glu Thr Phe Met Phe Pro Cys Gln His Cys Glu Arg Lys
        355                 360                 365             
Phe Thr Thr Lys Gln Gly Leu Glu Arg His Met His Ile His Ile Ser
    370                 375                 380                 
Thr Val Asn His Ala Phe Lys Cys Lys Tyr Cys Gly Lys Ala Phe Gly
385                 390                 395                 400 
Thr Gln Ile Asn Arg Arg Arg His Glu Arg Arg His Glu Ala Gly Leu
                405                 410                 415     
Lys Arg Lys Pro Ser Gln Thr Leu Gln Pro Ser Glu Asp Leu Ala Asp
            420                 425                 430         
Gly Lys Ala Ser Gly Glu Asn Val Ala Ser Lys Asp Asp Ser Ser Pro
        435                 440                 445             
Pro Ser Leu Gly Pro Asp Cys Leu Ile Met Asn Ser Glu Lys Ala Ser
    450                 455                 460                 
Gln Asp Thr Ile Asn Ser Ser Val Val Glu Glu Asn Gly Glu Val Lys
465                 470                 475                 480 
Glu Leu His Pro Cys Lys Tyr Cys Lys Lys Val Phe Gly Thr His Thr
                485                 490                 495     
Asn Met Arg Arg His Gln Arg Arg Val His Glu Arg His Leu Ile Pro
            500                 505                 510         
Lys Gly Val Arg Arg Lys Gly Gly Leu Glu Glu Pro Gln Pro Pro Ala
        515                 520                 525             
Glu Gln Ala Gln Ala Thr Gln Asn Val Tyr Val Pro Ser Thr Glu Pro
    530                 535                 540                 
Glu Glu Glu Gly Glu Ala Asp Asp Val Tyr Ile Met Asp Ile Ser Ser
545                 550                 555                 560 
Asn Ile Ser Glu Asn Leu Asn Tyr Tyr Ile Asp Gly Lys Ile Gln Thr
                565                 570                 575     
Asn Asn Asn Thr Ser Asn Cys Asp Val Ile Glu Met Glu Ser Ala Ser
            580                 585                 590         
Ala Asp Leu Tyr Gly Ile Asn Cys Leu Leu Thr Pro Val Thr Val Glu
        595                 600                 605             
Ile Thr Gln Asn Ile Lys Thr Thr Gln Val Pro Val Thr Glu Asp Leu
    610                 615                 620                 
Pro Lys Glu Pro Leu Gly Ser Thr Asn Ser Glu Ala Lys Lys Arg Arg
625                 630                 635                 640 
Thr Ala Ser Pro Pro Ala Leu Pro Lys Ile Lys Ala Glu Thr Asp Ser
                645                 650                 655     
Asp Pro Met Val Pro Ser Cys Ser Leu Ser Leu Pro Leu Ser Ile Ser
            660                 665                 670         
Thr Thr Glu Ala Val Ser Phe His Lys Glu Lys Ser Val Tyr Leu Ser
        675                 680                 685             
Ser Lys Leu Lys Gln Leu Leu Gln Thr Gln Asp Lys Leu Thr Pro Pro
    690                 695                 700                 
Ala Gly Ile Ser Ala Thr Glu Ile Ala Lys Leu Gly Pro Val Cys Val
705                 710                 715                 720 
Ser Ala Pro Ala Ser Met Leu Pro Val Thr Ser Ser Arg Phe Lys Arg
                725                 730                 735     
Arg Thr Ser Ser Pro Pro Ser Ser Pro Gln His Ser Pro Ala Leu Arg
            740                 745                 750         
Asp Phe Gly Lys Pro Ser Asp Gly Lys Ala Ala Trp Thr Asp Ala Gly
        755                 760                 765             
Leu Thr Ser Lys Lys Ser Lys Leu Glu Ser His Ser Asp Ser Pro Ala
    770                 775                 780                 
Trp Ser Leu Ser Gly Arg Asp Glu Arg Glu Thr Val Ser Pro Pro Cys
785                 790                 795                 800 
Phe Asp Glu Tyr Lys Met Ser Lys Glu Trp Thr Ala Ser Ser Ala Phe
                805                 810                 815     
Ser Ser Val Cys Asn Gln Gln Pro Leu Asp Leu Ser Ser Gly Val Lys
            820                 825                 830         
Gln Lys Ala Glu Gly Thr Gly Lys Thr Pro Val Gln Trp Glu Ser Val
        835                 840                 845             
Leu Asp Leu Ser Val His Lys Lys His Cys Ser Asp Ser Glu Gly Lys
    850                 855                 860                 
Glu Phe Lys Glu Ser His Ser Val Gln Pro Thr Cys Ser Ala Val Lys
865                 870                 875                 880 
Lys Arg Lys Pro Thr Thr Cys Met Leu Gln Lys Val Leu Leu Asn Glu
                885                 890                 895     
Tyr Asn Gly Ile Asp Leu Pro Val Glu Asn Pro Ala Asp Gly Thr Arg
            900                 905                 910         
Ser Pro Ser Pro Cys Lys Ser Leu Glu Ala Gln Pro Asp Pro Asp Leu
        915                 920                 925             
Gly Pro Gly Ser Gly Phe Pro Ala Pro Thr Val Glu Ser Thr Pro Asp
    930                 935                 940                 
Val Cys Pro Ser Ser Pro Ala Leu Gln Thr Pro Ser Leu Ser Ser Gly
945                 950                 955                 960 
Gln Leu Pro Pro Leu Leu Ile Pro Thr Asp Pro Ser Ser Pro Pro Pro
                965                 970                 975     
Cys Pro Pro Val Leu Thr Val Ala Thr Pro Pro Pro Pro Leu Leu Pro
            980                 985                 990         
Thr Val Pro Leu Pro Ala Pro Ser Ser Ser Ala Ser Pro His Pro Cys
        995                 1000                1005            
Pro Ser Pro Leu Ser Asn Ala Thr Ala Gln Ser Pro Leu Pro Ile Leu
    1010                1015                1020                
Ser Pro Thr Val Ser Pro Ser Pro Ser Pro Ile Pro Pro Val Glu Pro
1025                1030                1035                1040
Leu Met Ser Ala Ala Ser Pro Gly Pro Pro Thr Leu Ser Ser Ser Ser
                1045                1050                1055    
Ser Ser Ser Ser Ser Ser Ser Ser Phe Ser Ser Ser Ser Ser Ser Ser
            1060                1065                1070        
Ser Pro Ser Pro Pro Pro Leu Ser Ala Ile Ser Ser Val Val Ser Ser
        1075                1080                1085            
Gly Asp Asn Leu Glu Ala Ser Leu Pro Met Ile Ser Phe Lys Gln Glu
    1090                1095                1100                
Glu Leu Glu Asn Glu Gly Leu Lys Pro Arg Glu Glu Pro Gln Ser Ala
1105                1110                1115                1120
Ala Glu Gln Asp Val Val Val Gln Glu Thr Phe Asn Lys Asn Phe Val
                1125                1130                1135    
Cys Asn Val Cys Glu Ser Pro Phe Leu Ser Ile Lys Asp Leu Thr Lys
            1140                1145                1150        
His Leu Ser Ile His Ala Glu Glu Trp Pro Phe Lys Cys Glu Phe Cys
        1155                1160                1165            
Val Gln Leu Phe Lys Asp Lys Thr Asp Leu Ser Glu His Arg Phe Leu
    1170                1175                1180                
Leu His Gly Val Gly Asn Ile Phe Val Cys Ser Val Cys Lys Lys Glu
1185                1190                1195                1200
Phe Ala Phe Leu Cys Asn Leu Gln Gln His Gln Arg Asp Leu His Pro
                1205                1210                1215    
Asp Lys Val Cys Thr His His Glu Phe Glu Ser Gly Thr Leu Arg Pro
            1220                1225                1230        
Gln Asn Phe Thr Asp Pro Ser Lys Ala His Val Glu His Met Gln Ser
        1235                1240                1245            
Leu Pro Glu Asp Pro Leu Glu Thr Ser Lys Glu Glu Glu Glu Leu Asn
    1250                1255                1260                
Asp Ser Ser Glu Glu Leu Tyr Thr Thr Ile Lys Ile Met Ala Ser Gly
1265                1270                1275                1280
Ile Lys Thr Lys Asp Pro Asp Val Arg Leu Gly Leu Asn Gln His Tyr
                1285                1290                1295    
Pro Ser Phe Lys Pro Pro Pro Phe Gln Tyr His His Arg Asn Pro Met
            1300                1305                1310        
Gly Ile Gly Val Thr Ala Thr Asn Phe Thr Thr His Asn Ile Pro Gln
        1315                1320                1325            
Thr Phe Thr Thr Ala Ile Arg Cys Thr Lys Cys Gly Lys Gly Val Asp
    1330                1335                1340                
Asn Met Pro Glu Leu His Lys His Ile Leu Ala Cys Ala Ser Ala Ser
1345                1350                1355                1360
Asp Lys Lys Arg Tyr Thr Pro Lys Lys Asn Pro Val Pro Leu Lys Gln
                1365                1370                1375    
Thr Val Gln Pro Lys Asn Gly Val Val Val Leu Asp Asn Ser Gly Lys
            1380                1385                1390        
Asn Ala Phe Arg Arg Met Gly Gln Pro Lys Arg Leu Asn Phe Ser Val
        1395                1400                1405            
Glu Leu Ser Lys Met Ser Ser Asn Lys Leu Lys Leu Asn Ala Leu Lys
    1410                1415                1420                
Lys Lys Asn Gln Leu Val Gln Lys Ala Ile Leu Gln Lys Asn Lys Ser
1425                1430                1435                1440
Ala Lys Gln Lys Ala Asp Leu Lys Asn Ala Cys Glu Ser Ser Ser His
                1445                1450                1455    
Ile Cys Pro Tyr Cys Asn Arg Glu Phe Thr Tyr Ile Gly Ser Leu Asn
            1460                1465                1470        
Lys His Ala Ala Phe Ser Cys Pro Lys Lys Pro Leu Ser Pro Pro Lys
        1475                1480                1485            
Lys Lys Val Ser His Ser Ser Lys Lys Gly Gly His Ser Ser Pro Ala
    1490                1495                1500                
Ser Ser Asp Lys Asn Ser Asn Ser Asn His Arg Arg Arg Thr Ala Asp
1505                1510                1515                1520
Ala Glu Ile Lys Met Gln Ser Met Gln Thr Pro Leu Gly Lys Thr Arg
                1525                1530                1535    
Ala Arg Ser Ser Gly Pro Thr Gln Val Pro Leu Pro Ser Ser Ser Phe
            1540                1545                1550        
Arg Ser Lys Gln Asn Val Lys Phe Ala Ala Ser Val Lys Ser Lys Lys
        1555                1560                1565            
Pro Ser Ser Ser Ser Leu Arg Asn Ser Ser Pro Ile Arg Met Ala Lys
    1570                1575                1580                
Ile Thr His Val Glu Gly Lys Lys Pro Lys Ala Val Ala Lys Asn His
1585                1590                1595                1600
Ser Ala Gln Leu Ser Ser Lys Thr Ser Arg Ser Leu His Val Arg Val
                1605                1610                1615    
Gln Lys Ser Lys Ala Val Leu Gln Ser Lys Ser Thr Leu Ala Ser Lys
            1620                1625                1630        
Lys Arg Thr Asp Arg Phe Asn Ile Lys Ser Arg Glu Arg Ser Gly Gly
        1635                1640                1645            
Pro Val Thr Arg Ser Leu Gln Leu Ala Ala Ala Ala Asp Leu Ser Glu
    1650                1655                1660                
Asn Lys Arg Glu Asp Gly Ser Ala Lys Gln Glu Leu Lys Asp Phe Ser
1665                1670                1675                1680
Tyr Ser Leu Arg Leu Ala Ser Arg Cys Ser Pro Pro Ala Ala Pro Tyr
                1685                1690                1695    
Ile Thr Arg Gln Tyr Arg Lys Val Lys Ala Pro Ala Ala Ala Gln Phe
            1700                1705                1710        
Gln Gly Pro Phe Phe Lys Glu
        1715                


<210> 6865
<211> 537
<212> PRT
<213> Homo sapiens

<400> 6865
Met Ala Ala Gln Cys Val Thr Lys Val Ala Leu Asn Val Ser Cys Ala
 1               5                  10                  15      
Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val
            20                  25                  30          
Leu Phe Leu Asn Thr Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Thr
        35                  40                  45              
Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Thr Phe Ile
    50                  55                  60                  
Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr
65                  70                  75                  80  
Asp Ile Asp Asn Lys Thr Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly
                85                  90                  95      
Glu Cys Glu Cys Thr Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Thr
            100                 105                 110         
Arg Pro Leu Val Met Lys Thr Gly Arg Pro Ala Gly Lys Gly Ser Ile
        115                 120                 125             
Thr Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu
    130                 135                 140                 
Met Glu Ala Arg Lys Leu Asp Asn Lys Asp Leu Phe Gly Lys Ser Asp
145                 150                 155                 160 
Pro Tyr Leu Glu Phe His Lys Gln Thr Ser Asp Gly Asn Trp Leu Met
                165                 170                 175     
Val His Arg Thr Glu Val Val Lys Asn Asn Leu Asn Pro Val Trp Arg
            180                 185                 190         
Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp Lys
        195                 200                 205             
Thr Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His Asp
    210                 215                 220                 
Leu Ile Gly Thr Phe Gln Thr Thr Met Thr Lys Leu Lys Glu Ala Ser
225                 230                 235                 240 
Arg Ser Ser Pro Val Glu Phe Glu Cys Ile Asn Glu Lys Lys Arg Gln
                245                 250                 255     
Lys Lys Lys Ser Tyr Lys Asn Ser Gly Val Ile Ser Val Lys Gln Cys
            260                 265                 270         
Glu Ile Thr Val Glu Cys Thr Phe Leu Asp Tyr Ile Met Gly Gly Cys
        275                 280                 285             
Gln Leu Asn Phe Thr Val Gly Val Asp Phe Thr Gly Ser Asn Gly Asp
    290                 295                 300                 
Pro Arg Ser Pro Asp Ser Leu His Tyr Ile Ser Pro Asn Gly Val Asn
305                 310                 315                 320 
Glu Tyr Leu Thr Ala Leu Trp Ser Val Gly Leu Val Ile Gln Asp Tyr
                325                 330                 335     
Asp Ala Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Gln Ile Pro
            340                 345                 350         
Pro Gln Trp Gln Val Ser His Glu Phe Pro Met Asn Phe Asn Pro Ser
        355                 360                 365             
Asn Pro Tyr Cys Asn Gly Ile Gln Gly Ile Val Glu Ala Tyr Arg Ser
    370                 375                 380                 
Cys Leu Pro Gln Ile Lys Leu Tyr Gly Pro Thr Asn Phe Ser Pro Ile
385                 390                 395                 400 
Ile Asn His Val Ala Arg Phe Ala Ala Ala Ala Thr Gln Gln Gln Thr
                405                 410                 415     
Ala Ser Gln Tyr Phe Val Leu Leu Ile Ile Thr Asp Gly Val Ile Thr
            420                 425                 430         
Asp Leu Asp Glu Thr Arg Gln Ala Ile Val Asn Ala Ser Arg Leu Pro
        435                 440                 445             
Met Ser Ile Ile Ile Val Gly Val Gly Gly Ala Asp Phe Ser Ala Met
    450                 455                 460                 
Glu Phe Leu Asp Gly Asp Gly Gly Ser Leu Arg Ser Pro Leu Gly Glu
465                 470                 475                 480 
Val Ala Ile Arg Asp Ile Val Gln Phe Val Pro Phe Arg Gln Phe Gln
                485                 490                 495     
Asn Ala Pro Lys Glu Ala Leu Ala Gln Cys Val Leu Ala Glu Ile Pro
            500                 505                 510         
Gln Gln Val Val Gly Tyr Phe Asn Thr Tyr Lys Leu Leu Pro Pro Lys
        515                 520                 525             
Asn Pro Ala Thr Lys Gln Gln Lys Gln
    530                 535         


<210> 6866
<211> 344
<212> PRT
<213> Homo sapiens

<400> 6866
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15      
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30          
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45              
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60                  
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80  
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95      
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110         
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125             
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140                 
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160 
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175     
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190         
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205             
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220                 
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro
225                 230                 235                 240 
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255     
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270         
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285             
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300                 
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320 
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335     
Val Leu Ala Arg Val Ala Leu Ile
            340                 


<210> 6867
<211> 344
<212> PRT
<213> Homo sapiens

<400> 6867
Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys
 1               5                  10                  15      
Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30          
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45              
Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly
    50                  55                  60                  
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val
65                  70                  75                  80  
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95      
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110         
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
        115                 120                 125             
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
    130                 135                 140                 
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160 
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr
                165                 170                 175     
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190         
Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn
        195                 200                 205             
Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220                 
Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro
225                 230                 235                 240 
Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn
                245                 250                 255     
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270         
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285             
Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser
    290                 295                 300                 
Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly
305                 310                 315                 320 
Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly
                325                 330                 335     
Val Leu Ala Arg Val Ala Leu Ile
            340                 


<210> 6868
<211> 488
<212> PRT
<213> Homo sapiens

<400> 6868
Met Phe Ser Ala Leu Lys Tyr His Ala Ile Asp Tyr Leu Tyr Glu Asn
 1               5                  10                  15      
Val Val Arg Lys Lys Phe Tyr Arg Asp Ala Leu Leu Leu Arg Ile Pro
            20                  25                  30          
Ser Cys Leu Tyr Gln Asp Glu Ser Tyr His Val Ala Val Thr Asp Asn
        35                  40                  45              
Lys Phe Arg Arg Pro Trp Thr Arg Val Ser Ala Val Ser Val Pro Gly
    50                  55                  60                  
Met Thr Asp Thr Ser Val Leu Asp Gln Trp Lys Ala Ser Phe Phe Val
65                  70                  75                  80  
Glu Asp Phe Leu Glu Lys Lys Thr Ile Thr Arg Met Val Thr Gln Ile
                85                  90                  95      
Asn Cys Glu Phe Glu Glu Val Val Pro Ser Ser Asn Pro Asp Ser Gln
            100                 105                 110         
Ile Glu Val Glu Glu Val Ser Leu Tyr Thr His Met Asp Tyr Asn Glu
        115                 120                 125             
Val Phe Thr Pro Val Ser Cys Leu Glu Lys Cys Ser Ala Leu Gln Asn
    130                 135                 140                 
Gln Asn Gln Asp Leu Phe Ile Asp Asp Lys Gly Ile Leu Phe Val Ser
145                 150                 155                 160 
Ser Arg Lys His Leu Pro Thr Leu Pro Thr Leu Leu Ser Arg Leu Lys
                165                 170                 175     
Leu Phe Leu Val Lys Asp Pro Leu Leu Asp Phe Lys Gly Gln Ile Phe
            180                 185                 190         
Thr Glu Ala Asn Phe Ser Arg Glu Cys Phe Ser Leu Gln Glu Thr Leu
        195                 200                 205             
Glu Ala Phe Val Lys Glu Asp Phe Cys Met Asp Lys Val Asn Phe Cys
    210                 215                 220                 
Gln Glu Lys Leu Glu Asp Thr Ile Cys Leu Asn Glu Pro Ser Ser Phe
225                 230                 235                 240 
Leu Ile Glu Tyr Glu Phe Leu Ile Pro Pro Ser Leu Lys Pro Glu Ile
                245                 250                 255     
Asp Ile Pro Ser Leu Ser Glu Leu Lys Glu Leu Leu Asn Pro Val Pro
            260                 265                 270         
Glu Ile Ile Asn Tyr Val Asp Glu Lys Glu Lys Leu Phe Glu Arg Asp
        275                 280                 285             
Leu Thr Asn Lys His Gly Ile Glu Asp Ile Gly Asp Ile Lys Phe Ser
    290                 295                 300                 
Ser Thr Glu Ile Leu Thr Ile Gln Ser Gln Ser Glu Pro Glu Glu Cys
305                 310                 315                 320 
Ser Lys Pro Gly Glu Leu Glu Met Pro Leu Thr Pro Leu Phe Leu Thr
                325                 330                 335     
Cys Gln His Ser Ser Val Asn Ser Leu Arg Thr Glu Leu Gln Thr Phe
            340                 345                 350         
Pro Leu Ser Pro Val Cys Lys Ile Asn Leu Leu Thr Ala Glu Glu Ser
        355                 360                 365             
Ala Asn Glu Tyr Tyr Met Met Trp Gln Leu Glu Arg Cys Arg Ser Pro
    370                 375                 380                 
Leu Asn Pro Phe Leu Leu Thr Val Pro Arg Ile Gln Glu Pro His Ser
385                 390                 395                 400 
Gln Tyr Ser Val Thr Asp Leu Lys Lys Ile Phe Ser Val Lys Glu Glu
                405                 410                 415     
Ser Leu Val Ile Asn Leu Glu Lys Ala Glu Trp Trp Lys Gln Ala Gly
            420                 425                 430         
Leu Asn Leu Lys Met Met Glu Thr Leu Glu His Leu Asn Thr Tyr Leu
        435                 440                 445             
Cys His Asp Asn Leu Ser Ser Asn Asp Thr Lys Ile Glu Ile Phe Leu
    450                 455                 460                 
Pro Thr Lys Val Leu Gln Leu Glu Cys Lys Tyr Ile Thr Val Asn Ile
465                 470                 475                 480 
Ser Tyr Val Asn Ile Phe Arg Met
                485             


<210> 6869
<211> 6907
<212> PRT
<213> Homo sapiens

<400> 6869
Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp
 1               5                  10                  15      
Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr
            20                  25                  30          
Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His
        35                  40                  45              
Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly
    50                  55                  60                  
His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro
65                  70                  75                  80  
Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His
                85                  90                  95      
Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His
            100                 105                 110         
Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile
        115                 120                 125             
Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu
    130                 135                 140                 
Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp
145                 150                 155                 160 
Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln
                165                 170                 175     
Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln
            180                 185                 190         
Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser
        195                 200                 205             
Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg
    210                 215                 220                 
Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp
225                 230                 235                 240 
Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro
                245                 250                 255     
Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys
            260                 265                 270         
Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys Asp Ala
        275                 280                 285             
Pro Gly Thr Gly Glu Glu Ala Gln Gly Lys Val Lys Asp Ala Met Gly
    290                 295                 300                 
Trp Leu Thr Leu Gln Lys Glu Lys Leu Gln Lys Leu Leu Lys Asp Ser
305                 310                 315                 320 
Glu Asn Asp Thr Tyr Phe Lys Lys Tyr Asn Ser Leu Leu Ser Phe Met
                325                 330                 335     
Glu Ser Phe Asn Glu Glu Lys Lys Ser Phe Leu Asp Val Leu Ser Ile
            340                 345                 350         
Lys Arg Asp Leu Asp Glu Leu Asp Lys Asp His Leu Gln Leu Arg Glu
        355                 360                 365             
Ala Trp Asp Gly Leu Asp His Gln Ile Asn Ala Trp Lys Ile Lys Leu
    370                 375                 380                 
Asn Tyr Ala Leu Pro Pro Pro Leu His Gln Thr Glu Ala Trp Leu Gln
385                 390                 395                 400 
Glu Val Glu Glu Leu Met Asp Glu Asp Leu Ser Ala Ser Gln Asp His
                405                 410                 415     
Ser Gln Ala Val Thr Leu Ile Gln Glu Lys Met Thr Leu Phe Lys Ser
            420                 425                 430         
Leu Met Asp Arg Phe Glu His His Ser Asn Ile Leu Leu Thr Phe Glu
        435                 440                 445             
Asn Lys Asp Glu Asn His Leu Pro Leu Val Pro Pro Asn Lys Leu Glu
    450                 455                 460                 
Glu Met Lys Arg Arg Ile Asn Asn Ile Leu Glu Lys Lys Phe Ile Leu
465                 470                 475                 480 
Leu Leu Glu Phe His Tyr Tyr Lys Cys Leu Val Leu Gly Leu Val Asp
                485                 490                 495     
Glu Val Lys Ser Lys Leu Asp Ile Trp Asn Ile Lys Tyr Gly Ser Arg
            500                 505                 510         
Glu Ser Val Glu Leu Leu Leu Glu Asp Trp His Lys Phe Ile Glu Glu
        515                 520                 525             
Lys Glu Phe Leu Ala Arg Leu Asp Thr Ser Phe Gln Lys Cys Gly Glu
    530                 535                 540                 
Ile Tyr Lys Asn Leu Ala Gly Glu Cys Gln Asn Ile Asn Lys Gln Tyr
545                 550                 555                 560 
Met Met Val Lys Ser Asp Val Cys Met Tyr Arg Lys Asn Ile Tyr Asn
                565                 570                 575     
Val Lys Ser Thr Leu Gln Lys Val Leu Ala Cys Trp Ala Thr Tyr Val
            580                 585                 590         
Glu Asn Leu Arg Leu Leu Arg Ala Cys Phe Glu Glu Thr Lys Lys Glu
        595                 600                 605             
Glu Ile Lys Glu Val Pro Phe Glu Thr Leu Ala Gln Trp Asn Leu Glu
    610                 615                 620                 
His Ala Thr Leu Asn Glu Ala Gly Asn Phe Leu Val Glu Val Ser Asn
625                 630                 635                 640 
Asp Val Val Gly Ser Ser Ile Ser Lys Glu Leu Arg Arg Leu Asn Lys
                645                 650                 655     
Arg Trp Arg Lys Leu Val Ser Lys Thr Gln Leu Glu Met Asn Leu Pro
            660                 665                 670         
Leu Met Ile Lys Lys Gln Asp Gln Pro Thr Phe Asp Asn Ser Gly Asn
        675                 680                 685             
Ile Leu Ser Lys Glu Glu Lys Ala Thr Val Glu Phe Ser Thr Asp Met
    690                 695                 700                 
Ser Val Glu Leu Pro Glu Asn Tyr Asn Gln Asn Ile Lys Ala Gly Glu
705                 710                 715                 720 
Lys His Glu Lys Glu Asn Glu Glu Phe Thr Gly Gln Leu Lys Val Ala
                725                 730                 735     
Lys Asp Val Glu Lys Leu Ile Gly Gln Val Glu Ile Trp Glu Ala Glu
            740                 745                 750         
Ala Lys Ser Val Leu Asp Gln Asp Asp Val Asp Thr Ser Met Glu Glu
        755                 760                 765             
Ser Leu Lys His Leu Ile Ala Lys Gly Ser Met Phe Asp Glu Leu Met
    770                 775                 780                 
Ala Arg Ser Glu Asp Met Leu Gln Met Asp Ile Gln Asn Ile Ser Ser
785                 790                 795                 800 
Gln Glu Ser Phe Gln His Val Leu Thr Thr Gly Leu Gln Ala Lys Ile
                805                 810                 815     
Gln Glu Ala Lys Glu Lys Val Gln Ile Asn Val Val Lys Leu Ile Ala
            820                 825                 830         
Ala Leu Lys Asn Leu Thr Asp Val Ser Pro Asp Leu Asp Ile Arg Leu
        835                 840                 845             
Lys Met Glu Glu Ser Gln Lys Glu Leu Glu Ser Tyr Met Met Arg Ala
    850                 855                 860                 
Gln Gln Leu Leu Gly Gln Arg Glu Ser Pro Gly Glu Leu Ile Ser Lys
865                 870                 875                 880 
His Lys Glu Ala Leu Ile Ile Ser Asn Thr Lys Ser Leu Ala Lys Tyr
                885                 890                 895     
Leu Lys Ala Val Glu Glu Leu Lys Asn Asn Val Thr Glu Asp Ile Lys
            900                 905                 910         
Met Ser Leu Glu Glu Lys Ser Arg Asp Val Cys Ala Lys Trp Glu Ser
        915                 920                 925             
Leu His His Glu Leu Ser Leu Tyr Val Gln Gln Leu Lys Ile Asp Ile
    930                 935                 940                 
Glu Lys Gly Lys Leu Ser Asp Asn Ile Leu Lys Leu Glu Lys Gln Ile
945                 950                 955                 960 
Asn Lys Glu Lys Lys Leu Ile Arg Arg Gly Arg Thr Lys Gly Leu Ile
                965                 970                 975     
Lys Glu His Glu Ala Cys Phe Ser Glu Glu Gly Cys Leu Tyr Gln Leu
            980                 985                 990         
Asn His His Met Glu Val Leu Arg Glu Leu Cys Glu Glu Leu Pro Ser
        995                 1000                1005            
Gln Lys Ser Gln Gln Glu Val Lys Arg Leu Leu Lys Asp Tyr Glu Gln
    1010                1015                1020                
Lys Ile Glu Arg Leu Leu Lys Cys Ala Ser Glu Ile His Met Thr Leu
1025                1030                1035                1040
Gln Pro Thr Ala Gly Gly Thr Ser Lys Asn Glu Gly Thr Ile Thr Thr
                1045                1050                1055    
Ser Glu Asn Arg Gly Gly Asp Pro His Ser Glu Ala Pro Phe Ala Lys
            1060                1065                1070        
Ser Asp Asn Gln Pro Ser Thr Glu Lys Ala Met Glu Pro Thr Met Lys
        1075                1080                1085            
Phe Ser Leu Ala Ser Val Leu Arg Pro Leu Gln Glu Glu Ser Ile Met
    1090                1095                1100                
Glu Lys Asp Tyr Ser Ala Ser Ile Asn Ser Leu Leu Glu Arg Tyr Asp
1105                1110                1115                1120
Thr Tyr Arg Asp Ile Leu Glu His His Leu Gln Asn Asn Lys Phe Arg
                1125                1130                1135    
Ile Thr Ser Asp Phe Ser Ser Glu Glu Asp Arg Ser Ser Ser Cys Leu
            1140                1145                1150        
Gln Ala Lys Leu Thr Asp Leu Gln Val Ile Lys Asn Glu Thr Asp Ala
        1155                1160                1165            
Arg Trp Lys Glu Phe Glu Ile Ile Ser Leu Lys Leu Glu Asn His Val
    1170                1175                1180                
Asn Asp Ile Lys Lys Pro Phe Val Ile Lys Glu Arg Asp Thr Leu Lys
1185                1190                1195                1200
Glu Arg Glu Arg Glu Leu Gln Met Thr Leu Asn Thr Arg Met Glu Ser
                1205                1210                1215    
Leu Glu Thr Ala Leu Arg Leu Val Leu Pro Val Glu Lys Ala Ser Leu
            1220                1225                1230        
Leu Leu Cys Gly Ser Asp Leu Pro Leu His Lys Met Ala Ile Gln Gly
        1235                1240                1245            
Phe His Leu Ile Asp Ala Asp Arg Ile Tyr Gln His Leu Arg Asn Ile
    1250                1255                1260                
Gln Asp Ser Ile Ala Lys Gln Ile Glu Ile Cys Asn Arg Leu Glu Glu
1265                1270                1275                1280
Pro Gly Asn Phe Val Leu Lys Glu Leu His Pro Phe Asp Leu His Ala
                1285                1290                1295    
Met Gln Asn Ile Ile Leu Lys Tyr Lys Thr Gln Phe Glu Gly Met Asn
            1300                1305                1310        
His Arg Val Gln Arg Ser Glu Asp Thr Leu Lys Ala Leu Glu Asp Phe
        1315                1320                1325            
Leu Ala Ser Leu Arg Thr Ala Lys Leu Ser Ala Glu Pro Val Thr Asp
    1330                1335                1340                
Leu Ser Ala Ser Asp Thr Gln Val Ala Gln Glu Asn Thr Leu Thr Val
1345                1350                1355                1360
Lys Asn Lys Glu Gly Glu Ile His Leu Met Lys Asp Lys Ala Lys His
                1365                1370                1375    
Leu Asp Lys Cys Leu Lys Met Leu Asp Met Ser Phe Lys Asp Ala Glu
            1380                1385                1390        
Arg Gly Asp Asp Thr Ser Cys Glu Asn Leu Leu Asp Ala Phe Ser Ile
        1395                1400                1405            
Lys Leu Ser Glu Thr His Gly Tyr Gly Val Gln Glu Glu Phe Thr Glu
    1410                1415                1420                
Glu Asn Lys Leu Leu Glu Ala Cys Ile Phe Lys Asn Asn Glu Leu Leu
1425                1430                1435                1440
Lys Asn Ile Gln Asp Val Gln Ser Gln Ile Ser Lys Ile Gly Leu Lys
                1445                1450                1455    
Asp Pro Thr Val Pro Ala Val Lys His Arg Lys Lys Ser Leu Ile Arg
            1460                1465                1470        
Leu Asp Lys Val Leu Asp Glu Tyr Glu Glu Glu Lys Arg His Leu Gln
        1475                1480                1485            
Glu Met Ala Asn Ser Leu Pro His Phe Lys Asp Gly Arg Glu Lys Thr
    1490                1495                1500                
Val Asn Gln Gln Cys Gln Asn Thr Val Val Leu Trp Glu Asn Thr Lys
1505                1510                1515                1520
Ala Leu Val Thr Glu Cys Leu Glu Gln Cys Gly Arg Val Leu Glu Leu
                1525                1530                1535    
Leu Lys Gln Tyr Gln Asn Phe Lys Ser Ile Leu Thr Thr Leu Ile Gln
            1540                1545                1550        
Lys Glu Glu Ser Val Ile Ser Leu Gln Ala Ser Tyr Met Gly Lys Glu
        1555                1560                1565            
Asn Leu Lys Lys Arg Ile Ala Glu Ile Glu Ile Val Lys Glu Glu Phe
    1570                1575                1580                
Asn Glu His Leu Glu Val Val Asp Lys Ile Asn Gln Val Cys Lys Asn
1585                1590                1595                1600
Leu Gln Phe Tyr Leu Asn Lys Met Lys Thr Phe Glu Glu Pro Pro Phe
                1605                1610                1615    
Glu Lys Glu Ala Asn Ile Ile Val Asp Arg Trp Leu Asp Ile Asn Glu
            1620                1625                1630        
Lys Thr Glu Asp Tyr Tyr Glu Asn Leu Gly Arg Ala Leu Ala Leu Trp
        1635                1640                1645            
Asp Lys Leu Phe Asn Leu Lys Asn Val Ile Asp Glu Trp Thr Glu Lys
    1650                1655                1660                
Ala Leu Gln Lys Met Glu Leu His Gln Leu Thr Glu Glu Asp Arg Glu
1665                1670                1675                1680
Arg Leu Lys Glu Glu Leu Gln Val His Glu Gln Lys Thr Ser Glu Phe
                1685                1690                1695    
Ser Arg Arg Val Ala Glu Ile Gln Phe Leu Leu Gln Ser Ser Glu Ile
            1700                1705                1710        
Pro Leu Glu Leu Gln Val Met Glu Ser Ser Ile Leu Asn Lys Met Glu
        1715                1720                1725            
His Val Gln Lys Cys Leu Thr Gly Glu Ser Asn Cys His Ala Leu Ser
    1730                1735                1740                
Gly Ser Thr Ala Glu Leu Arg Glu Asp Leu Asp Gln Ala Lys Thr Gln
1745                1750                1755                1760
Ile Gly Met Thr Glu Ser Leu Leu Lys Ala Leu Ser Pro Ser Asp Ser
                1765                1770                1775    
Leu Glu Ile Phe Thr Lys Leu Glu Glu Ile Gln Gln Gln Ile Leu Gln
            1780                1785                1790        
Gln Lys His Ser Met Ile Leu Leu Glu Asn Gln Ile Gly Cys Leu Thr
        1795                1800                1805            
Pro Glu Leu Ser Glu Leu Lys Lys Gln Tyr Glu Ser Val Ser Asp Leu
    1810                1815                1820                
Phe Asn Thr Lys Lys Ser Val Leu Gln Asp His Phe Ser Lys Leu Leu
1825                1830                1835                1840
Asn Asp Gln Cys Lys Asn Phe Asn Asp Trp Phe Ser Asn Ile Lys Val
                1845                1850                1855    
Asn Leu Lys Glu Cys Phe Glu Ser Ser Glu Thr Lys Lys Ser Val Glu
            1860                1865                1870        
Gln Lys Leu Gln Lys Leu Ser Asp Phe Leu Thr Leu Glu Gly Arg Asn
        1875                1880                1885            
Ser Lys Ile Lys Gln Val Asp Ser Val Leu Lys His Val Lys Lys His
    1890                1895                1900                
Leu Pro Lys Ala His Val Lys Glu Leu Ile Ser Trp Leu Val Gly Gln
1905                1910                1915                1920
Glu Phe Glu Leu Glu Lys Met Glu Ser Ile Cys Gln Ala Arg Ala Lys
                1925                1930                1935    
Glu Leu Glu Asp Ser Leu Gln Gln Leu Leu Arg Leu Gln Asp Asp His
            1940                1945                1950        
Arg Asn Leu Arg Lys Trp Leu Thr Asn Gln Glu Glu Lys Trp Lys Gly
        1955                1960                1965            
Met Glu Glu Pro Gly Glu Lys Thr Glu Leu Phe Cys Gln Ala Leu Ala
    1970                1975                1980                
Arg Lys Arg Glu Gln Phe Glu Ser Val Ala Gln Leu Asn Asn Ser Leu
1985                1990                1995                2000
Lys Glu Tyr Gly Phe Thr Glu Glu Glu Glu Ile Ile Met Glu Ala Thr
                2005                2010                2015    
Cys Leu Met Asp Arg Tyr Gln Thr Leu Leu Arg Gln Leu Ser Glu Ile
            2020                2025                2030        
Glu Glu Glu Asp Lys Leu Leu Pro Thr Glu Asp Gln Ser Phe Asn Asp
        2035                2040                2045            
Leu Ala His Asp Val Ile His Trp Ile Lys Glu Ile Lys Glu Ser Leu
    2050                2055                2060                
Met Val Leu Asn Ser Ser Glu Gly Lys Met Pro Leu Glu Glu Arg Ile
2065                2070                2075                2080
Gln Lys Ile Lys Glu Ile Ile Leu Leu Lys Pro Glu Gly Asp Ala Arg
                2085                2090                2095    
Ile Glu Thr Ile Met Lys Gln Ala Glu Ser Ser Glu Ala Pro Leu Val
            2100                2105                2110        
Gln Lys Thr Leu Thr Asp Ile Ser Asn Gln Trp Asp Asn Thr Leu His
        2115                2120                2125            
Leu Ala Ser Thr Tyr Leu Ser His Gln Glu Lys Leu Leu Leu Glu Gly
    2130                2135                2140                
Glu Lys Tyr Leu Gln Ser Lys Glu Asp Leu Arg Leu Met Leu Ile Glu
2145                2150                2155                2160
Leu Lys Lys Lys Gln Glu Ala Gly Phe Ala Leu Gln His Gly Leu Gln
                2165                2170                2175    
Glu Lys Lys Ala Gln Leu Lys Ile Tyr Lys Lys Phe Leu Lys Lys Ala
            2180                2185                2190        
Gln Asp Leu Thr Ser Leu Leu Lys Glu Leu Lys Ser Gln Gly Asn Tyr
        2195                2200                2205            
Leu Leu Glu Cys Thr Lys Asn Pro Ser Phe Ser Glu Glu Pro Trp Leu
    2210                2215                2220                
Glu Ile Lys His Leu His Glu Ser Leu Leu Gln Gln Leu Gln Asp Ser
2225                2230                2235                2240
Val Gln Asn Leu Asp Gly His Val Arg Glu His Asp Ser Tyr Gln Val
                2245                2250                2255    
Cys Val Thr Asp Leu Asn Thr Thr Leu Asp Asn Phe Ser Lys Glu Phe
            2260                2265                2270        
Val Ser Phe Ser Asp Lys Pro Val Asp Gln Ile Ala Val Glu Glu Lys
        2275                2280                2285            
Leu Gln Lys Leu Gln Glu Leu Glu Asn Arg Leu Ser Leu Gln Asp Gly
    2290                2295                2300                
Thr Leu Lys Lys Ile Leu Ala Leu Ala Lys Ser Val Lys Gln Asn Thr
2305                2310                2315                2320
Ser Ser Val Gly Gln Lys Ile Ile Lys Asp Asp Ile Lys Ser Leu Gln
                2325                2330                2335    
Cys Lys Gln Lys Asp Leu Glu Asn Arg Leu Ala Ser Ala Lys Gln Glu
            2340                2345                2350        
Met Glu Cys Cys Leu Asn Ser Ile Leu Lys Ser Lys Arg Ser Thr Glu
        2355                2360                2365            
Lys Lys Gly Lys Phe Thr Leu Pro Gly Arg Glu Lys Gln Ala Thr Ser
    2370                2375                2380                
Asp Val Gln Glu Ser Thr Gln Glu Ser Ala Ala Val Glu Lys Leu Glu
2385                2390                2395                2400
Glu Asp Trp Glu Ile Asn Lys Asp Ser Ala Val Glu Met Ala Met Ser
                2405                2410                2415    
Lys Gln Leu Ser Leu Asn Ala Gln Glu Ser Met Lys Asn Thr Glu Asp
            2420                2425                2430        
Glu Arg Lys Val Asn Glu Leu Gln Asn Gln Pro Leu Glu Leu Asp Thr
        2435                2440                2445            
Met Leu Arg Asn Glu Gln Leu Glu Glu Ile Glu Lys Leu Tyr Thr Gln
    2450                2455                2460                
Leu Glu Ala Lys Lys Ala Ala Ile Lys Pro Leu Glu Gln Thr Glu Cys
2465                2470                2475                2480
Leu Asn Lys Thr Glu Thr Gly Ala Leu Val Leu His Asn Ile Gly Tyr
                2485                2490                2495    
Ser Ala Gln His Leu Asp Asn Leu Leu Gln Ala Leu Ile Thr Leu Lys
            2500                2505                2510        
Lys Asn Lys Glu Ser Gln Tyr Cys Val Leu Arg Asp Phe Gln Glu Tyr
        2515                2520                2525            
Leu Ala Ala Val Glu Ser Ser Met Lys Ala Leu Leu Thr Asp Lys Glu
    2530                2535                2540                
Ser Leu Lys Val Gly Pro Leu Asp Ser Val Thr Tyr Leu Asp Lys Ile
2545                2550                2555                2560
Lys Lys Phe Ile Ala Ser Ile Glu Lys Glu Lys Asp Ser Leu Gly Asn
                2565                2570                2575    
Leu Lys Ile Lys Trp Glu Asn Leu Ser Asn His Val Thr Asp Met Asp
            2580                2585                2590        
Lys Lys Leu Leu Glu Ser Gln Ile Lys Gln Leu Glu His Gly Trp Glu
        2595                2600                2605            
Gln Val Glu Gln Gln Ile Gln Lys Lys Tyr Ser Gln Gln Val Val Glu
    2610                2615                2620                
Tyr Asp Glu Phe Thr Thr Leu Met Asn Lys Val Gln Asp Thr Glu Ile
2625                2630                2635                2640
Ser Leu Gln Gln Gln Gln Gln His Leu Gln Leu Arg Leu Lys Ser Pro
                2645                2650                2655    
Glu Glu Arg Ala Gly Asn Gln Ser Met Ile Ala Leu Thr Thr Asp Leu
            2660                2665                2670        
Gln Ala Thr Lys His Gly Phe Ser Val Leu Lys Gly Gln Ala Glu Leu
        2675                2680                2685            
Gln Met Lys Arg Ile Trp Gly Glu Lys Glu Lys Lys Asn Leu Glu Asp
    2690                2695                2700                
Gly Ile Asn Asn Leu Lys Lys Gln Trp Glu Thr Leu Glu Pro Leu His
2705                2710                2715                2720
Leu Glu Ala Glu Asn Gln Ile Lys Lys Cys Asp Ile Arg Asn Lys Met
                2725                2730                2735    
Lys Glu Thr Ile Leu Trp Ala Lys Asn Leu Leu Gly Glu Leu Asn Pro
            2740                2745                2750        
Ser Ile Pro Leu Leu Pro Asp Asp Ile Leu Ser Gln Ile Arg Lys Cys
        2755                2760                2765            
Lys Val Thr His Asp Gly Ile Leu Ala Arg Gln Gln Ser Val Glu Ser
    2770                2775                2780                
Leu Ala Glu Glu Val Lys Asp Lys Val Pro Ser Leu Thr Thr Tyr Glu
2785                2790                2795                2800
Gly Ser Asp Leu Asn Asn Thr Leu Glu Asp Leu Arg Asn Gln Tyr Gln
                2805                2810                2815    
Met Leu Val Leu Lys Ser Thr Gln Arg Ser Gln Gln Leu Glu Phe Lys
            2820                2825                2830        
Leu Glu Glu Arg Ser Asn Phe Phe Ala Ile Ile Arg Lys Phe Gln Leu
        2835                2840                2845            
Met Val Gln Glu Ser Glu Thr Leu Ile Ile Pro Arg Val Glu Thr Ala
    2850                2855                2860                
Ala Thr Glu Ala Glu Leu Lys His His His Val Thr Leu Glu Ala Ser
2865                2870                2875                2880
Gln Lys Glu Leu Gln Glu Ile Asp Ser Gly Ile Ser Thr His Leu Gln
                2885                2890                2895    
Glu Leu Thr Asn Ile Tyr Glu Glu Leu Asn Val Phe Glu Arg Leu Phe
            2900                2905                2910        
Leu Glu Asp Gln Leu Lys Asn Leu Lys Ile Arg Thr Asn Arg Ile Gln
        2915                2920                2925            
Arg Phe Ile Gln Asn Thr Cys Asn Glu Val Glu His Lys Ile Lys Phe
    2930                2935                2940                
Cys Arg Gln Phe His Glu Lys Thr Ser Ala Leu Gln Glu Glu Ala Asp
2945                2950                2955                2960
Ser Ile Gln Arg Asn Glu Leu Leu Leu Asn Gln Glu Val Asn Lys Gly
                2965                2970                2975    
Val Lys Glu Glu Ile Tyr Asn Leu Lys Asp Arg Leu Thr Ala Ile Lys
            2980                2985                2990        
Cys Cys Ile Leu Gln Val Leu Lys Leu Lys Lys Val Phe Asp Tyr Ile
        2995                3000                3005            
Gly Leu Asn Trp Asp Phe Ser Gln Leu Asp Gln Leu Gln Thr Gln Val
    3010                3015                3020                
Phe Glu Lys Glu Lys Glu Leu Glu Glu Lys Ile Lys Gln Leu Asp Thr
3025                3030                3035                3040
Phe Glu Glu Glu His Gly Lys Tyr Gln Ala Leu Leu Ser Lys Met Arg
                3045                3050                3055    
Ala Ile Asp Leu Gln Ile Lys Lys Met Thr Glu Val Val Leu Lys Ala
            3060                3065                3070        
Pro Asp Ser Ser Pro Glu Ser Arg Arg Leu Asn Ala Gln Ile Leu Ser
        3075                3080                3085            
Gln Arg Ile Glu Lys Ala Lys Cys Leu Cys Asp Glu Ile Ile Lys Lys
    3090                3095                3100                
Leu Asn Glu Asn Lys Thr Phe Asp Asp Ser Phe Lys Glu Lys Glu Ile
3105                3110                3115                3120
Leu Gln Ile Lys Leu Asn Ala Glu Glu Asn Asp Lys Leu Tyr Lys Val
                3125                3130                3135    
Leu Gln Asn Met Val Leu Glu Leu Ser Pro Lys Glu Leu Asp Glu Lys
            3140                3145                3150        
Asn Cys Gln Asp Lys Leu Glu Thr Ser Leu His Val Leu Asn Gln Ile
        3155                3160                3165            
Lys Ser Gln Leu Gln Gln Pro Leu Leu Ile Asn Leu Glu Ile Lys His
    3170                3175                3180                
Ile Gln Asn Glu Lys Asp Asn Cys Glu Ala Phe Gln Glu Gln Val Trp
3185                3190                3195                3200
Ala Glu Met Cys Ser Ile Lys Ala Val Thr Ala Ile Glu Lys Gln Arg
                3205                3210                3215    
Glu Glu Asn Ser Ser Glu Ala Ser Asp Val Glu Thr Lys Leu Arg Glu
            3220                3225                3230        
Phe Glu Asp Leu Gln Met Gln Leu Asn Thr Ser Ile Asp Leu Arg Thr
        3235                3240                3245            
Asn Val Leu Asn Asp Ala Tyr Glu Asn Leu Thr Arg Tyr Lys Glu Ala
    3250                3255                3260                
Val Thr Arg Ala Val Glu Ser Ile Thr Ser Leu Glu Ala Ile Ile Ile
3265                3270                3275                3280
Pro Tyr Arg Val Asp Val Gly Asn Pro Glu Glu Ser Leu Glu Met Pro
                3285                3290                3295    
Leu Arg Lys Gln Glu Glu Leu Glu Ser Thr Val Ala His Ile Gln Asp
            3300                3305                3310        
Leu Thr Glu Lys Leu Gly Met Ile Ser Ser Pro Glu Ala Lys Leu Gln
        3315                3320                3325            
Leu Gln Tyr Thr Leu Gln Glu Leu Val Ser Lys Asn Ser Ala Met Lys
    3330                3335                3340                
Glu Ala Phe Lys Ala Gln Glu Thr Glu Ala Glu Arg Tyr Leu Glu Asn
3345                3350                3355                3360
Tyr Lys Cys Tyr Arg Lys Met Glu Glu Asp Ile Tyr Thr Asn Leu Ser
                3365                3370                3375    
Lys Met Glu Thr Val Leu Gly Gln Ser Met Ser Ser Leu Pro Leu Ser
            3380                3385                3390        
Tyr Arg Glu Ala Leu Glu Arg Leu Glu Gln Ser Lys Ala Leu Val Ser
        3395                3400                3405            
Asn Leu Ile Ser Thr Lys Glu Glu Leu Met Lys Leu Arg Gln Ile Leu
    3410                3415                3420                
Arg Leu Leu Arg Leu Arg Cys Thr Glu Asn Asp Gly Ile Cys Leu Leu
3425                3430                3435                3440
Lys Ile Val Ser Ala Leu Trp Glu Lys Trp Leu Ser Leu Leu Glu Ala
                3445                3450                3455    
Ala Lys Glu Trp Glu Met Trp Cys Glu Glu Leu Lys Gln Glu Trp Lys
            3460                3465                3470        
Phe Val Ser Glu Glu Ile Glu Arg Glu Ala Ile Ile Leu Asp Asn Leu
        3475                3480                3485            
Gln Glu Glu Leu Pro Glu Ile Ser Lys Thr Lys Glu Ala Ala Thr Thr
    3490                3495                3500                
Glu Glu Leu Ser Glu Leu Leu Asp Cys Leu Cys Gln Tyr Gly Glu Asn
3505                3510                3515                3520
Val Glu Lys Gln Gln Leu Leu Leu Thr Leu Leu Leu Gln Arg Ile Arg
                3525                3530                3535    
Ser Ile Gln Asn Val Pro Glu Ser Ser Gly Ala Val Glu Thr Val Pro
            3540                3545                3550        
Ala Phe Gln Glu Ile Thr Ser Met Lys Glu Arg Cys Asn Lys Leu Leu
        3555                3560                3565            
Gln Lys Val Gln Lys Asn Lys Glu Leu Val Gln Thr Glu Ile Gln Glu
    3570                3575                3580                
Arg His Ser Phe Thr Lys Glu Ile Ile Ala Leu Lys Asn Phe Phe Gln
3585                3590                3595                3600
Gln Thr Thr Thr Ser Phe Gln Asn Met Ala Phe Gln Asp His Pro Glu
                3605                3610                3615    
Lys Ser Glu Gln Phe Glu Glu Leu Gln Ser Ile Leu Lys Lys Gly Lys
            3620                3625                3630        
Leu Thr Phe Glu Asn Ile Met Glu Lys Leu Arg Ile Lys Tyr Ser Glu
        3635                3640                3645            
Met Tyr Thr Ile Val Pro Ala Glu Ile Glu Ser Gln Val Glu Glu Cys
    3650                3655                3660                
Arg Lys Ala Leu Glu Asp Ile Asp Glu Lys Ile Ser Asn Glu Val Leu
3665                3670                3675                3680
Lys Ser Ser Pro Ser Tyr Ala Met Arg Arg Lys Ile Glu Glu Ile Asn
                3685                3690                3695    
Asn Gly Leu His Asn Val Glu Lys Met Leu Gln Gln Lys Ser Lys Asn
            3700                3705                3710        
Ile Glu Lys Ala Gln Glu Ile Gln Lys Lys Met Trp Asp Glu Leu Asp
        3715                3720                3725            
Leu Trp His Ser Lys Leu Asn Glu Leu Asp Ser Glu Val Gln Asp Ile
    3730                3735                3740                
Val Glu Gln Asp Pro Gly Gln Ala Gln Glu Trp Met Asp Asn Leu Met
3745                3750                3755                3760
Ile Pro Phe Gln Gln Tyr Gln Gln Val Ser Gln Arg Ala Glu Cys Arg
                3765                3770                3775    
Thr Ser Gln Leu Asn Lys Ala Thr Val Lys Met Glu Glu Tyr Ser Asp
            3780                3785                3790        
Leu Leu Lys Ser Thr Glu Ala Trp Ile Glu Asn Thr Ser His Leu Leu
        3795                3800                3805            
Ala Asn Pro Ala Asp Tyr Asp Ser Leu Arg Thr Leu Ser His His Ala
    3810                3815                3820                
Ser Thr Val Gln Met Ala Leu Glu Asp Ser Glu Gln Lys His Asn Leu
3825                3830                3835                3840
Leu His Ser Ile Phe Met Asp Leu Glu Asp Leu Ser Ile Ile Phe Glu
                3845                3850                3855    
Thr Asp Glu Leu Thr Gln Ser Ile Gln Glu Leu Ser Asn Gln Val Thr
            3860                3865                3870        
Ala Leu Gln Gln Lys Ile Met Glu Ser Leu Pro Gln Ile Gln Arg Met
        3875                3880                3885            
Ala Asp Asp Val Val Ala Ile Glu Ser Glu Val Lys Ser Met Glu Lys
    3890                3895                3900                
Arg Val Ser Lys Ile Lys Thr Ile Leu Leu Ser Lys Glu Ile Phe Asp
3905                3910                3915                3920
Phe Ser Pro Glu Glu His Leu Lys His Gly Glu Val Ile Leu Glu Asn
                3925                3930                3935    
Ile Arg Pro Met Lys Lys Thr Ile Ala Glu Ile Val Ser Tyr Gln Val
            3940                3945                3950        
Glu Leu Arg Leu Pro Gln Thr Gly Met Lys Pro Leu Pro Val Phe Gln
        3955                3960                3965            
Arg Thr Asn Gln Leu Leu Gln Asp Ile Lys Leu Leu Glu Asn Val Thr
    3970                3975                3980                
Gln Glu Gln Asn Glu Leu Leu Lys Val Val Ile Lys Gln Thr Asn Glu
3985                3990                3995                4000
Gln Asp Glu Glu Ile Glu Asn Leu Lys Gln Ile Leu Asn Asn Tyr Ser
                4005                4010                4015    
Ala Gln Phe Ser Leu Glu His Met Ser Pro Asp Gln Ala Asp Lys Leu
            4020                4025                4030        
Pro Gln Leu Gln Gly Glu Ile Glu Arg Met Glu Lys Gln Ile Leu Ser
        4035                4040                4045            
Leu Asn Gln Arg Lys Glu Asp Leu Leu Val Asp Leu Lys Ala Thr Val
    4050                4055                4060                
Leu Asn Leu His Gln His Leu Lys Gln Glu Gln Glu Gly Val Glu Arg
4065                4070                4075                4080
Asp Arg Leu Pro Ala Val Thr Ser Glu Glu Gly Gly Val Ala Glu Arg
                4085                4090                4095    
Asp Ala Ser Glu Arg Lys Leu Asn Arg Arg Gly Ser Met Ser Tyr Leu
            4100                4105                4110        
Ala Ala Val Glu Glu Glu Val Glu Glu Ser Ser Val Lys Ser Asp Asn
        4115                4120                4125            
Gly Asp Glu Lys Ala Glu Pro Ser Pro Gln Ser Trp Ser Ser Leu Trp
    4130                4135                4140                
Lys His Asp Lys Asp Met Glu Glu Asp Arg Ala Ser Ser Ser Ser Gly
4145                4150                4155                4160
Thr Ile Val Gln Glu Ala Tyr Gly Lys Ile Ser Thr Ser Asp Asn Ser
                4165                4170                4175    
Met Ala Gln Ile Leu Thr Pro Asp Ser Leu Asn Thr Glu Gln Gly Pro
            4180                4185                4190        
Glu Cys Ser Leu Arg Pro Asn Gln Thr Glu Glu Gly Thr Thr Pro Pro
        4195                4200                4205            
Ile Glu Ala Asp Thr Leu Asp Ser Ser Asp Ala Gln Gly Gly Leu Glu
    4210                4215                4220                
Pro Arg Val Glu Lys Thr Arg Pro Glu Pro Thr Glu Val Leu His Ala
4225                4230                4235                4240
Cys Lys Thr Gln Val Ala Glu Leu Glu Leu Trp Leu Gln Gln Ala Asn
                4245                4250                4255    
Val Ala Val Glu Pro Glu Thr Leu Asn Ala Asp Met Gln Gln Val Leu
            4260                4265                4270        
Glu Gln Gln Leu Val Gly Cys Gln Ala Met Leu Thr Glu Ile Glu His
        4275                4280                4285            
Lys Val Ala Phe Leu Leu Glu Thr Cys Lys Asp Gln Gly Leu Gly Asp
    4290                4295                4300                
Asn Gly Ala Thr Gln His Glu Ala Glu Ala Leu Ser Leu Lys Leu Lys
4305                4310                4315                4320
Thr Val Lys Cys Asn Leu Glu Lys Val Gln Met Met Leu Gln Glu Lys
                4325                4330                4335    
His Ser Glu Asp Gln His Pro Thr Ile Leu Lys Lys Ser Ser Glu Pro
            4340                4345                4350        
Glu His Gln Glu Ala Leu Gln Pro Val Asn Leu Ser Glu Leu Glu Ser
        4355                4360                4365            
Ile Val Thr Glu Arg Pro Gln Phe Ser Arg Gln Lys Asp Phe Gln Gln
    4370                4375                4380                
Gln Gln Val Leu Glu Leu Lys Pro Met Glu Gln Lys Asp Phe Ile Lys
4385                4390                4395                4400
Phe Ile Glu Phe Asn Ala Lys Lys Met Trp Pro Gln Tyr Cys Gln His
                4405                4410                4415    
Asp Asn Asp Thr Thr Gln Glu Ser Ser Ala Ser Asn Gln Ala Ser Ser
            4420                4425                4430        
Pro Glu Asn Asp Val Pro Asp Ser Ile Leu Ser Pro Gln Gly Gln Asn
        4435                4440                4445            
Gly Asp Lys Trp Gln Tyr Leu His His Glu Leu Ser Ser Lys Ile Lys
    4450                4455                4460                
Leu Pro Leu Pro Gln Leu Val Glu Pro Gln Val Ser Thr Asn Met Gly
4465                4470                4475                4480
Ile Leu Pro Ser Val Thr Met Tyr Asn Phe Arg Tyr Pro Thr Thr Glu
                4485                4490                4495    
Glu Leu Lys Thr Tyr Thr Thr Gln Leu Glu Asp Leu Arg Gln Glu Ala
            4500                4505                4510        
Ser Asn Leu Gln Thr Gln Glu Asn Met Thr Glu Glu Ala Tyr Ile Asn
        4515                4520                4525            
Leu Asp Lys Lys Leu Phe Glu Leu Phe Leu Thr Leu Ser Gln Cys Leu
    4530                4535                4540                
Ser Ser Val Glu Glu Met Leu Glu Met Pro Arg Leu Tyr Arg Glu Asp
4545                4550                4555                4560
Gly Ser Gly Gln Gln Val His Tyr Glu Thr Leu Ala Leu Glu Leu Lys
                4565                4570                4575    
Lys Leu Tyr Leu Ala Leu Ser Asp Lys Lys Gly Asp Leu Leu Lys Ala
            4580                4585                4590        
Met Thr Trp Pro Gly Glu Asn Thr Asn Leu Leu Leu Glu Cys Phe Asp
        4595                4600                4605            
Asn Leu Gln Val Cys Leu Glu His Thr Gln Ala Ala Ala Val Cys Arg
    4610                4615                4620                
Ser Lys Ser Leu Lys Ala Gly Leu Asp Tyr Asn Arg Ser Tyr Gln Asn
4625                4630                4635                4640
Glu Ile Lys Arg Leu Tyr His Gln Leu Ile Lys Ser Lys Thr Ser Leu
                4645                4650                4655    
Gln Gln Ser Leu Asn Glu Ile Ser Gly Gln Ser Val Ala Glu Gln Leu
            4660                4665                4670        
Gln Lys Ala Asp Ala Tyr Thr Val Glu Leu Glu Asn Ala Glu Ser Arg
        4675                4680                4685            
Val Ala Lys Leu Arg Asp Glu Gly Glu Arg Leu His Leu Pro Tyr Ala
    4690                4695                4700                
Leu Leu Gln Glu Val Tyr Lys Leu Glu Asp Val Leu Asp Ser Met Trp
4705                4710                4715                4720
Gly Met Leu Arg Ala Arg Tyr Thr Glu Leu Ser Ser Pro Phe Val Thr
                4725                4730                4735    
Glu Ser Gln Gln Asp Ala Leu Leu Gln Gly Met Val Glu Leu Val Lys
            4740                4745                4750        
Ile Gly Lys Glu Lys Leu Ala His Gly His Leu Lys Gln Thr Lys Ser
        4755                4760                4765            
Lys Val Ala Leu Gln Ala Gln Ile Glu Asn His Lys Val Phe Phe Gln
    4770                4775                4780                
Lys Leu Val Ala Asp Met Leu Leu Ile Gln Ala Tyr Ser Ala Lys Ile
4785                4790                4795                4800
Leu Pro Ser Leu Leu Gln Asn Arg Glu Thr Phe Trp Ala Glu Gln Val
                4805                4810                4815    
Thr Glu Val Lys Ile Leu Glu Glu Lys Ser Arg Gln Cys Gly Met Lys
            4820                4825                4830        
Leu Gln Ser Leu Leu Gln Lys Trp Glu Glu Phe Asp Glu Asn Tyr Ala
        4835                4840                4845            
Ser Leu Glu Lys Asp Leu Glu Ile Leu Ile Ser Thr Leu Pro Ser Val
    4850                4855                4860                
Ser Leu Val Glu Glu Thr Glu Glu Arg Leu Val Glu Arg Ile Ser Phe
4865                4870                4875                4880
Tyr Gln Gln Ile Lys Arg Asn Ile Gly Gly Lys His Ala Arg Leu Tyr
                4885                4890                4895    
Gln Thr Leu Asn Glu Gly Lys Gln Leu Val Ala Ser Val Ser Cys Pro
            4900                4905                4910        
Glu Leu Glu Gly Gln Ile Ala Lys Leu Glu Glu Gln Trp Leu Ser Leu
        4915                4920                4925            
Asn Lys Lys Ile Asp His Glu Leu His Arg Leu Gln Ala Leu Leu Lys
    4930                4935                4940                
His Leu Leu Ser Tyr Asn Arg Asp Ser Asp Gln Leu Thr Lys Trp Leu
4945                4950                4955                4960
Glu Ser Ser Gln His Thr Leu Asn Tyr Trp Lys Glu Gln Ser Leu Asn
                4965                4970                4975    
Val Ser Gln Asp Leu Asp Thr Ile Arg Ser Asn Ile Asn Asn Phe Phe
            4980                4985                4990        
Glu Phe Ser Lys Glu Val Asp Glu Lys Ser Ser Leu Lys Thr Ala Val
        4995                5000                5005            
Ile Ser Ile Gly Asn Gln Leu Leu His Leu Lys Glu Thr Asp Thr Ala
    5010                5015                5020                
Thr Leu Arg Ala Ser Leu Ala Gln Phe Glu Gln Lys Trp Thr Met Leu
5025                5030                5035                5040
Ile Thr Gln Leu Pro Asp Ile Gln Glu Lys Leu His Gln Leu Gln Met
                5045                5050                5055    
Glu Lys Leu Pro Ser Arg Lys Ala Ile Thr Glu Met Ile Ser Trp Met
            5060                5065                5070        
Asn Asn Val Glu His Gln Thr Ser Asp Glu Asp Ser Val His Ser Pro
        5075                5080                5085            
Ser Ser Ala Ser Gln Val Lys His Leu Leu Gln Lys His Lys Glu Phe
    5090                5095                5100                
Arg Met Glu Met Asp Tyr Lys Gln Trp Ile Val Asp Phe Val Asn Gln
5105                5110                5115                5120
Ser Leu Leu Gln Leu Ser Thr Cys Asp Val Glu Ser Lys Arg Tyr Glu
                5125                5130                5135    
Arg Thr Glu Phe Ala Glu His Leu Gly Glu Met Asn Arg Gln Trp His
            5140                5145                5150        
Arg Val His Gly Met Leu Asn Arg Lys Ile Gln His Leu Glu Gln Leu
        5155                5160                5165            
Leu Glu Ser Ile Thr Glu Ser Glu Asn Lys Ile Gln Ile Leu Asn Asn
    5170                5175                5180                
Trp Leu Glu Ala Gln Glu Glu Arg Leu Lys Thr Leu Gln Lys Pro Glu
5185                5190                5195                5200
Ser Val Ile Ser Val Gln Lys Leu Leu Leu Asp Cys Gln Asp Ile Glu
                5205                5210                5215    
Asn Gln Leu Ala Ile Lys Ser Lys Ala Leu Asp Glu Leu Lys Gln Ser
            5220                5225                5230        
Tyr Leu Thr Leu Glu Ser Gly Ala Val Pro Leu Leu Glu Asp Thr Ala
        5235                5240                5245            
Ser Arg Ile Asp Glu Leu Phe Gln Lys Arg Ser Ser Val Leu Thr Gln
    5250                5255                5260                
Val Asn Gln Leu Lys Thr Ser Met Gln Ser Val Leu Gln Glu Trp Lys
5265                5270                5275                5280
Ile Tyr Asp Gln Leu Tyr Asp Glu Val Asn Met Met Thr Ile Arg Phe
                5285                5290                5295    
Trp Tyr Cys Met Glu His Ser Lys Pro Val Val Leu Ser Leu Glu Thr
            5300                5305                5310        
Leu Arg Cys Gln Val Glu Asn Leu Gln Ser Leu Gln Asp Glu Ala Glu
        5315                5320                5325            
Ser Ser Glu Gly Ser Trp Glu Lys Leu Gln Glu Val Ile Gly Lys Leu
    5330                5335                5340                
Lys Gly Leu Cys Pro Ser Val Ala Glu Ile Ile Glu Glu Lys Cys Gln
5345                5350                5355                5360
Asn Thr His Lys Arg Trp Thr Gln Val Asn Gln Ala Ile Ala Asp Gln
                5365                5370                5375    
Leu Gln Lys Ala Gln Ser Leu Leu Gln Leu Trp Lys Ala Tyr Ser Asn
            5380                5385                5390        
Ala His Gly Glu Ala Ala Ala Arg Leu Lys Gln Gln Glu Ala Lys Phe
        5395                5400                5405            
Gln Gln Leu Ala Asn Ile Ser Met Ser Gly Asn Asn Leu Ala Glu Ile
    5410                5415                5420                
Leu Pro Pro Ala Leu Gln Asp Ile Lys Glu Leu Gln His Asp Val Gln
5425                5430                5435                5440
Lys Thr Lys Glu Ala Phe Leu Gln Asn Ser Ser Val Leu Asp Arg Leu
                5445                5450                5455    
Pro Gln Pro Ala Glu Ser Ser Thr His Met Leu Leu Pro Gly Pro Leu
            5460                5465                5470        
His Ser Leu Gln Arg Ala Ala Tyr Leu Glu Lys Met Leu Leu Val Lys
        5475                5480                5485            
Ala Asn Glu Phe Glu Phe Val Leu Ser Gln Phe Lys Asp Phe Gly Val
    5490                5495                5500                
Arg Leu Glu Ser Leu Lys Gly Leu Ile Met His Glu Glu Glu Asn Leu
5505                5510                5515                5520
Asp Arg Leu His Gln Gln Glu Lys Glu Asn Pro Asp Ser Phe Leu Asn
                5525                5530                5535    
His Val Leu Ala Leu Thr Ala Gln Ser Pro Asp Ile Glu His Leu Asn
            5540                5545                5550        
Glu Val Ser Leu Lys Leu Pro Leu Ser Asp Val Ala Val Lys Thr Leu
        5555                5560                5565            
Gln Asn Met Asn Arg Gln Trp Ile Arg Ala Thr Ala Thr Ala Leu Glu
    5570                5575                5580                
Arg Cys Ser Glu Leu Gln Gly Ile Gly Leu Asn Glu Lys Phe Leu Tyr
5585                5590                5595                5600
Cys Cys Glu Lys Trp Ile Gln Leu Leu Glu Lys Ile Glu Glu Ala Leu
                5605                5610                5615    
Lys Val Asp Val Ala Asn Ser Leu Pro Glu Leu Leu Glu Gln Gln Lys
            5620                5625                5630        
Thr Tyr Lys Met Leu Glu Ala Glu Val Ser Ile Asn Gln Thr Ile Ala
        5635                5640                5645            
Asp Ser Tyr Val Thr Gln Ser Leu Gln Leu Leu Asp Thr Thr Glu Ile
    5650                5655                5660                
Glu Asn Arg Pro Glu Phe Ile Thr Glu Phe Ser Lys Leu Thr Asp Arg
5665                5670                5675                5680
Trp Gln Asn Ala Val Gln Gly Val Arg Gln Arg Lys Gly Asp Val Asp
                5685                5690                5695    
Gly Leu Val Arg Gln Trp Gln Asp Phe Thr Thr Ser Val Glu Asn Leu
            5700                5705                5710        
Phe Arg Phe Leu Thr Asp Thr Ser His Leu Leu Ser Ala Val Lys Gly
        5715                5720                5725            
Gln Glu Arg Phe Ser Leu Tyr Gln Thr Arg Ser Leu Ile His Glu Leu
    5730                5735                5740                
Lys Asn Lys Glu Ile His Phe Gln Arg Arg Arg Thr Thr Cys Ala Leu
5745                5750                5755                5760
Thr Leu Glu Ala Gly Glu Lys Leu Leu Leu Thr Thr Asp Leu Lys Thr
                5765                5770                5775    
Lys Glu Ser Val Gly Arg Arg Ile Ser Gln Leu Gln Asp Ser Trp Lys
            5780                5785                5790        
Asp Met Glu Pro Gln Leu Ala Glu Met Ile Lys Gln Phe Gln Ser Thr
        5795                5800                5805            
Val Glu Thr Trp Asp Gln Cys Glu Lys Lys Ile Lys Glu Leu Lys Ser
    5810                5815                5820                
Arg Leu Gln Val Leu Lys Ala Gln Ser Glu Asp Pro Leu Pro Glu Leu
5825                5830                5835                5840
His Glu Asp Leu His Asn Glu Lys Glu Leu Ile Lys Glu Leu Glu Gln
                5845                5850                5855    
Ser Leu Ala Ser Trp Thr Gln Asn Leu Lys Glu Leu Gln Thr Met Lys
            5860                5865                5870        
Ala Asp Leu Thr Arg His Val Leu Val Glu Asp Val Met Val Leu Lys
        5875                5880                5885            
Glu Gln Ile Glu His Leu His Arg Gln Trp Glu Asp Leu Cys Leu Arg
    5890                5895                5900                
Val Ala Ile Arg Lys Gln Glu Ile Glu Asp Arg Leu Asn Thr Trp Val
5905                5910                5915                5920
Val Phe Asn Glu Lys Asn Lys Glu Leu Cys Ala Trp Leu Val Gln Met
                5925                5930                5935    
Glu Asn Lys Val Leu Gln Thr Ala Asp Ile Ser Ile Glu Glu Met Ile
            5940                5945                5950        
Glu Lys Leu Gln Lys Asp Cys Met Glu Glu Ile Asn Leu Phe Ser Glu
        5955                5960                5965            
Asn Lys Leu Gln Leu Lys Gln Met Gly Asp Gln Leu Ile Lys Ala Ser
    5970                5975                5980                
Asn Lys Ser Arg Ala Ala Glu Ile Asp Asp Lys Leu Asn Lys Ile Asn
5985                5990                5995                6000
Asp Arg Trp Gln His Leu Phe Asp Val Ile Gly Ser Arg Val Lys Lys
                6005                6010                6015    
Leu Lys Glu Thr Phe Ala Phe Ile Gln Gln Leu Asp Lys Asn Met Ser
            6020                6025                6030        
Asn Leu Arg Thr Trp Leu Ala Arg Ile Glu Ser Glu Leu Ser Lys Pro
        6035                6040                6045            
Val Val Tyr Asp Val Cys Asp Asp Gln Glu Ile Gln Lys Arg Leu Ala
    6050                6055                6060                
Glu Gln Gln Asp Leu Gln Arg Asp Ile Glu Gln His Ser Ala Gly Val
6065                6070                6075                6080
Glu Ser Val Phe Asn Ile Cys Asp Val Leu Leu His Asp Ser Asp Ala
                6085                6090                6095    
Cys Ala Asn Glu Thr Glu Cys Asp Ser Ile Gln Gln Thr Thr Arg Ser
            6100                6105                6110        
Leu Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met Glu Arg Arg
        6115                6120                6125            
Met Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe Leu Asp Asp
    6130                6135                6140                
Tyr Ser Arg Phe Glu Asp Trp Leu Lys Ser Ala Glu Arg Thr Ala Ala
6145                6150                6155                6160
Cys Pro Asn Ser Ser Glu Val Leu Tyr Thr Ser Ala Lys Glu Glu Leu
                6165                6170                6175    
Lys Arg Phe Glu Ala Phe Gln Arg Gln Ile His Glu Arg Leu Thr Gln
            6180                6185                6190        
Leu Glu Leu Ile Asn Lys Gln Tyr Arg Arg Leu Ala Arg Glu Asn Arg
        6195                6200                6205            
Thr Asp Thr Ala Ser Arg Leu Lys Gln Met Val His Glu Gly Asn Gln
    6210                6215                6220                
Arg Trp Asp Asn Leu Gln Arg Arg Val Thr Ala Val Leu Arg Arg Leu
6225                6230                6235                6240
Arg His Phe Thr Asn Gln Arg Glu Glu Phe Glu Gly Thr Arg Glu Ser
                6245                6250                6255    
Ile Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr Asn Val Glu
            6260                6265                6270        
His Phe Ser Glu Ser Asp Ala Asp Asp Lys Met Arg Gln Leu Asn Gly
        6275                6280                6285            
Phe Gln Gln Glu Ile Thr Leu Asn Thr Asn Lys Ile Asp Gln Leu Ile
    6290                6295                6300                
Val Phe Gly Glu Gln Leu Ile Gln Lys Ser Glu Pro Leu Asp Ala Val
6305                6310                6315                6320
Leu Ile Glu Asp Glu Leu Glu Glu Leu His Arg Tyr Cys Gln Glu Val
                6325                6330                6335    
Phe Gly Arg Val Ser Arg Phe His Arg Arg Leu Thr Ser Cys Thr Pro
            6340                6345                6350        
Gly Leu Glu Asp Glu Lys Glu Ala Ser Glu Asn Glu Thr Asp Met Glu
        6355                6360                6365            
Asp Pro Arg Glu Ile Gln Thr Asp Ser Trp Arg Lys Arg Gly Glu Ser
    6370                6375                6380                
Glu Glu Pro Ser Ser Pro Gln Ser Leu Cys His Leu Val Ala Pro Gly
6385                6390                6395                6400
His Glu Arg Ser Gly Cys Glu Thr Pro Val Ser Val Asp Ser Ile Pro
                6405                6410                6415    
Leu Glu Trp Asp His Thr Gly Asp Val Gly Gly Ser Ser Ser His Glu
            6420                6425                6430        
Glu Asp Glu Glu Gly Pro Tyr Tyr Ser Ala Leu Ser Asp Val Glu Ile
        6435                6440                6445            
Pro Glu Asn Pro Glu Ala Tyr Leu Lys Met Thr Thr Lys Thr Leu Lys
    6450                6455                6460                
Ala Ser Ser Gly Lys Ser Ile Ser Asp Gly His Ser Trp His Val Pro
6465                6470                6475                6480
Asp Ser Pro Ser Cys Pro Glu His His Tyr Lys Gln Met Glu Gly Asp
                6485                6490                6495    
Arg Asn Val Pro Pro Val Pro Pro Ala Ser Ser Thr Pro Tyr Lys Pro
            6500                6505                6510        
Pro Tyr Gly Lys Leu Leu Leu Pro Pro Gly Thr Asp Gly Gly Lys Glu
        6515                6520                6525            
Gly Pro Arg Val Leu Asn Gly Asn Pro Gln Gln Glu Asp Gly Gly Leu
    6530                6535                6540                
Ala Gly Ile Thr Glu Gln Gln Ser Gly Ala Phe Asp Arg Trp Glu Met
6545                6550                6555                6560
Ile Gln Ala Gln Glu Leu His Asn Lys Leu Lys Ile Lys Gln Asn Leu
                6565                6570                6575    
Gln Gln Leu Asn Ser Asp Ile Ser Ala Ile Thr Thr Trp Leu Lys Lys
            6580                6585                6590        
Thr Glu Ala Glu Leu Glu Met Leu Lys Met Ala Lys Pro Pro Ser Asp
        6595                6600                6605            
Ile Gln Glu Ile Glu Leu Arg Val Lys Arg Leu Gln Glu Ile Leu Lys
    6610                6615                6620                
Ala Phe Asp Thr Tyr Lys Ala Leu Val Val Ser Val Asn Val Ser Ser
6625                6630                6635                6640
Lys Glu Phe Leu Gln Thr Glu Ser Pro Glu Ser Thr Glu Leu Gln Ser
                6645                6650                6655    
Arg Leu Arg Gln Leu Ser Leu Leu Trp Glu Ala Ala Gln Gly Ala Val
            6660                6665                6670        
Asp Ser Trp Arg Gly Gly Leu Arg Gln Ser Leu Met Gln Cys Gln Asp
        6675                6680                6685            
Phe His Gln Leu Ser Gln Asn Leu Leu Leu Trp Leu Ala Ser Ala Lys
    6690                6695                6700                
Asn Arg Arg Gln Lys Ala His Val Thr Asp Pro Lys Ala Asp Pro Arg
6705                6710                6715                6720
Ala Leu Leu Glu Cys Arg Arg Glu Leu Met Gln Leu Glu Lys Glu Leu
                6725                6730                6735    
Val Glu Arg Gln Pro Gln Val Asp Met Leu Gln Glu Ile Ser Asn Ser
            6740                6745                6750        
Leu Leu Ile Lys Gly His Gly Glu Asp Cys Ile Glu Ala Glu Glu Lys
        6755                6760                6765            
Val His Val Ile Glu Lys Lys Leu Lys Gln Leu Arg Glu Gln Val Ser
    6770                6775                6780                
Gln Asp Leu Met Ala Leu Gln Gly Thr Gln Asn Pro Ala Ser Pro Leu
6785                6790                6795                6800
Pro Ser Phe Asp Glu Val Asp Ser Gly Asp Gln Pro Pro Ala Thr Ser
                6805                6810                6815    
Val Pro Ala Pro Arg Ala Lys Phe Arg Ala Val Arg Thr Thr Glu Gly
            6820                6825                6830        
Glu Glu Glu Thr Glu Ser Arg Val Pro Gly Ser Thr Arg Pro Gln Arg
        6835                6840                6845            
Ser Phe Leu Ser Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu Leu
    6850                6855                6860                
Leu Leu Leu Leu Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu Glu
6865                6870                6875                6880
Asp Tyr Ser Cys Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr Pro
                6885                6890                6895    
Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Thr
            6900                6905        


<210> 6870
<211> 6885
<212> PRT
<213> Homo sapiens

<400> 6870
Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp
 1               5                  10                  15      
Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr
            20                  25                  30          
Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His
        35                  40                  45              
Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly
    50                  55                  60                  
His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro
65                  70                  75                  80  
Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His
                85                  90                  95      
Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His
            100                 105                 110         
Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile
        115                 120                 125             
Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu
    130                 135                 140                 
Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp
145                 150                 155                 160 
Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln
                165                 170                 175     
Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln
            180                 185                 190         
Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser
        195                 200                 205             
Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg
    210                 215                 220                 
Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp
225                 230                 235                 240 
Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro
                245                 250                 255     
Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys
            260                 265                 270         
Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys Asp Ala
        275                 280                 285             
Pro Gly Thr Gly Glu Glu Ala Gln Gly Lys Val Lys Asp Ala Met Gly
    290                 295                 300                 
Trp Leu Thr Leu Gln Lys Glu Lys Leu Gln Lys Leu Leu Lys Asp Ser
305                 310                 315                 320 
Glu Asn Asp Thr Tyr Phe Lys Lys Tyr Asn Ser Leu Leu Ser Phe Met
                325                 330                 335     
Glu Ser Phe Asn Glu Glu Lys Lys Ser Phe Leu Asp Val Leu Ser Ile
            340                 345                 350         
Lys Arg Asp Leu Asp Glu Leu Asp Lys Asp His Leu Gln Leu Arg Glu
        355                 360                 365             
Ala Trp Asp Gly Leu Asp His Gln Ile Asn Ala Trp Lys Ile Lys Leu
    370                 375                 380                 
Asn Tyr Ala Leu Pro Pro Pro Leu His Gln Thr Glu Ala Trp Leu Gln
385                 390                 395                 400 
Glu Val Glu Glu Leu Met Asp Glu Asp Leu Ser Ala Ser Gln Asp His
                405                 410                 415     
Ser Gln Ala Val Thr Leu Ile Gln Glu Lys Met Thr Leu Phe Lys Ser
            420                 425                 430         
Leu Met Asp Arg Phe Glu His His Ser Asn Ile Leu Leu Thr Phe Glu
        435                 440                 445             
Asn Lys Asp Glu Asn His Leu Pro Leu Val Pro Pro Asn Lys Leu Glu
    450                 455                 460                 
Glu Met Lys Arg Arg Ile Asn Asn Ile Leu Glu Lys Lys Phe Ile Leu
465                 470                 475                 480 
Leu Leu Glu Phe His Tyr Tyr Lys Cys Leu Val Leu Gly Leu Val Asp
                485                 490                 495     
Glu Val Lys Ser Lys Leu Asp Ile Trp Asn Ile Lys Tyr Gly Ser Arg
            500                 505                 510         
Glu Ser Val Glu Leu Leu Leu Glu Asp Trp His Lys Phe Ile Glu Glu
        515                 520                 525             
Lys Glu Phe Leu Ala Arg Leu Asp Thr Ser Phe Gln Lys Cys Gly Glu
    530                 535                 540                 
Ile Tyr Lys Asn Leu Ala Gly Glu Cys Gln Asn Ile Asn Lys Gln Tyr
545                 550                 555                 560 
Met Met Val Lys Ser Asp Val Cys Met Tyr Arg Lys Asn Ile Tyr Asn
                565                 570                 575     
Val Lys Ser Thr Leu Gln Lys Val Leu Ala Cys Trp Ala Thr Tyr Val
            580                 585                 590         
Glu Asn Leu Arg Leu Leu Arg Ala Cys Phe Glu Glu Thr Lys Lys Glu
        595                 600                 605             
Glu Ile Lys Glu Val Pro Phe Glu Thr Leu Ala Gln Trp Asn Leu Glu
    610                 615                 620                 
His Ala Thr Leu Asn Glu Ala Gly Asn Phe Leu Val Glu Val Ser Asn
625                 630                 635                 640 
Asp Val Val Gly Ser Ser Ile Ser Lys Glu Leu Arg Arg Leu Asn Lys
                645                 650                 655     
Arg Trp Arg Lys Leu Val Ser Lys Thr Gln Leu Glu Met Asn Leu Pro
            660                 665                 670         
Leu Met Ile Lys Lys Gln Asp Gln Pro Thr Phe Asp Asn Ser Gly Asn
        675                 680                 685             
Ile Leu Ser Lys Glu Glu Lys Ala Thr Val Glu Phe Ser Thr Asp Met
    690                 695                 700                 
Ser Val Glu Leu Pro Glu Asn Tyr Asn Gln Asn Ile Lys Ala Gly Glu
705                 710                 715                 720 
Lys His Glu Lys Glu Asn Glu Glu Phe Thr Gly Gln Leu Lys Val Ala
                725                 730                 735     
Lys Asp Val Glu Lys Leu Ile Gly Gln Val Glu Ile Trp Glu Ala Glu
            740                 745                 750         
Ala Lys Ser Val Leu Asp Gln Asp Asp Val Asp Thr Ser Met Glu Glu
        755                 760                 765             
Ser Leu Lys His Leu Ile Ala Lys Gly Ser Met Phe Asp Glu Leu Met
    770                 775                 780                 
Ala Arg Ser Glu Asp Met Leu Gln Met Asp Ile Gln Asn Ile Ser Ser
785                 790                 795                 800 
Gln Glu Ser Phe Gln His Val Leu Thr Thr Gly Leu Gln Ala Lys Ile
                805                 810                 815     
Gln Glu Ala Lys Glu Lys Val Gln Ile Asn Val Val Lys Leu Ile Ala
            820                 825                 830         
Ala Leu Lys Asn Leu Thr Asp Val Ser Pro Asp Leu Asp Ile Arg Leu
        835                 840                 845             
Lys Met Glu Glu Ser Gln Lys Glu Leu Glu Ser Tyr Met Met Arg Ala
    850                 855                 860                 
Gln Gln Leu Leu Gly Gln Arg Glu Ser Pro Gly Glu Leu Ile Ser Lys
865                 870                 875                 880 
His Lys Glu Ala Leu Ile Ile Ser Asn Thr Lys Ser Leu Ala Lys Tyr
                885                 890                 895     
Leu Lys Ala Val Glu Glu Leu Lys Asn Asn Val Thr Glu Asp Ile Lys
            900                 905                 910         
Met Ser Leu Glu Glu Lys Ser Arg Asp Val Cys Ala Lys Trp Glu Ser
        915                 920                 925             
Leu His His Glu Leu Ser Leu Tyr Val Gln Gln Leu Lys Ile Asp Ile
    930                 935                 940                 
Glu Lys Gly Lys Leu Ser Asp Asn Ile Leu Lys Leu Glu Lys Gln Ile
945                 950                 955                 960 
Asn Lys Glu Lys Lys Leu Ile Arg Arg Gly Arg Thr Lys Gly Leu Ile
                965                 970                 975     
Lys Glu His Glu Ala Cys Phe Ser Glu Glu Gly Cys Leu Tyr Gln Leu
            980                 985                 990         
Asn His His Met Glu Val Leu Arg Glu Leu Cys Glu Glu Leu Pro Ser
        995                 1000                1005            
Gln Lys Ser Gln Gln Glu Val Lys Arg Leu Leu Lys Asp Tyr Glu Gln
    1010                1015                1020                
Lys Ile Glu Arg Leu Leu Lys Cys Ala Ser Glu Ile His Met Thr Leu
1025                1030                1035                1040
Gln Pro Thr Ala Gly Gly Thr Ser Lys Asn Glu Gly Thr Ile Thr Thr
                1045                1050                1055    
Ser Glu Asn Arg Gly Gly Asp Pro His Ser Glu Ala Pro Phe Ala Lys
            1060                1065                1070        
Ser Asp Asn Gln Pro Ser Thr Glu Lys Ala Met Glu Pro Thr Met Lys
        1075                1080                1085            
Phe Ser Leu Ala Ser Val Leu Arg Pro Leu Gln Glu Glu Ser Ile Met
    1090                1095                1100                
Glu Lys Asp Tyr Ser Ala Ser Ile Asn Ser Leu Leu Glu Arg Tyr Asp
1105                1110                1115                1120
Thr Tyr Arg Asp Ile Leu Glu His His Leu Gln Asn Asn Lys Phe Arg
                1125                1130                1135    
Ile Thr Ser Asp Phe Ser Ser Glu Glu Asp Arg Ser Ser Ser Cys Leu
            1140                1145                1150        
Gln Ala Lys Leu Thr Asp Leu Gln Val Ile Lys Asn Glu Thr Asp Ala
        1155                1160                1165            
Arg Trp Lys Glu Phe Glu Ile Ile Ser Leu Lys Leu Glu Asn His Val
    1170                1175                1180                
Asn Asp Ile Lys Lys Pro Phe Val Ile Lys Glu Arg Asp Thr Leu Lys
1185                1190                1195                1200
Glu Arg Glu Arg Glu Leu Gln Met Thr Leu Asn Thr Arg Met Glu Ser
                1205                1210                1215    
Leu Glu Thr Ala Leu Arg Leu Val Leu Pro Val Glu Lys Ala Ser Leu
            1220                1225                1230        
Leu Leu Cys Gly Ser Asp Leu Pro Leu His Lys Met Ala Ile Gln Gly
        1235                1240                1245            
Phe His Leu Ile Asp Ala Asp Arg Ile Tyr Gln His Leu Arg Asn Ile
    1250                1255                1260                
Gln Asp Ser Ile Ala Lys Gln Ile Glu Ile Cys Asn Arg Leu Glu Glu
1265                1270                1275                1280
Pro Gly Asn Phe Val Leu Lys Glu Leu His Pro Phe Asp Leu His Ala
                1285                1290                1295    
Met Gln Asn Ile Ile Leu Lys Tyr Lys Thr Gln Phe Glu Gly Met Asn
            1300                1305                1310        
His Arg Val Gln Arg Ser Glu Asp Thr Leu Lys Ala Leu Glu Asp Phe
        1315                1320                1325            
Leu Ala Ser Leu Arg Thr Ala Lys Leu Ser Ala Glu Pro Val Thr Asp
    1330                1335                1340                
Leu Ser Ala Ser Asp Thr Gln Val Ala Gln Glu Asn Thr Leu Thr Val
1345                1350                1355                1360
Lys Asn Lys Glu Gly Glu Ile His Leu Met Lys Asp Lys Ala Lys His
                1365                1370                1375    
Leu Asp Lys Cys Leu Lys Met Leu Asp Met Ser Phe Lys Asp Ala Glu
            1380                1385                1390        
Arg Gly Asp Asp Thr Ser Cys Glu Asn Leu Leu Asp Ala Phe Ser Ile
        1395                1400                1405            
Lys Leu Ser Glu Thr His Gly Tyr Gly Val Gln Glu Glu Phe Thr Glu
    1410                1415                1420                
Glu Asn Lys Leu Leu Glu Ala Cys Ile Phe Lys Asn Asn Glu Leu Leu
1425                1430                1435                1440
Lys Asn Ile Gln Asp Val Gln Ser Gln Ile Ser Lys Ile Gly Leu Lys
                1445                1450                1455    
Asp Pro Thr Val Pro Ala Val Lys His Arg Lys Lys Ser Leu Ile Arg
            1460                1465                1470        
Leu Asp Lys Val Leu Asp Glu Tyr Glu Glu Glu Lys Arg His Leu Gln
        1475                1480                1485            
Glu Met Ala Asn Ser Leu Pro His Phe Lys Asp Gly Arg Glu Lys Thr
    1490                1495                1500                
Val Asn Gln Gln Cys Gln Asn Thr Val Val Leu Trp Glu Asn Thr Lys
1505                1510                1515                1520
Ala Leu Val Thr Glu Cys Leu Glu Gln Cys Gly Arg Val Leu Glu Leu
                1525                1530                1535    
Leu Lys Gln Tyr Gln Asn Phe Lys Ser Ile Leu Thr Thr Leu Ile Gln
            1540                1545                1550        
Lys Glu Glu Ser Val Ile Ser Leu Gln Ala Ser Tyr Met Gly Lys Glu
        1555                1560                1565            
Asn Leu Lys Lys Arg Ile Ala Glu Ile Glu Ile Val Lys Glu Glu Phe
    1570                1575                1580                
Asn Glu His Leu Glu Val Val Asp Lys Ile Asn Gln Val Cys Lys Asn
1585                1590                1595                1600
Leu Gln Phe Tyr Leu Asn Lys Met Lys Thr Phe Glu Glu Pro Pro Phe
                1605                1610                1615    
Glu Lys Glu Ala Asn Ile Ile Val Asp Arg Trp Leu Asp Ile Asn Glu
            1620                1625                1630        
Lys Thr Glu Asp Tyr Tyr Glu Asn Leu Gly Arg Ala Leu Ala Leu Trp
        1635                1640                1645            
Asp Lys Leu Phe Asn Leu Lys Asn Val Ile Asp Glu Trp Thr Glu Lys
    1650                1655                1660                
Ala Leu Gln Lys Met Glu Leu His Gln Leu Thr Glu Glu Asp Arg Glu
1665                1670                1675                1680
Arg Leu Lys Glu Glu Leu Gln Val His Glu Gln Lys Thr Ser Glu Phe
                1685                1690                1695    
Ser Arg Arg Val Ala Glu Ile Gln Phe Leu Leu Gln Ser Ser Glu Ile
            1700                1705                1710        
Pro Leu Glu Leu Gln Val Met Glu Ser Ser Ile Leu Asn Lys Met Glu
        1715                1720                1725            
His Val Gln Lys Cys Leu Thr Gly Glu Ser Asn Cys His Ala Leu Ser
    1730                1735                1740                
Gly Ser Thr Ala Glu Leu Arg Glu Asp Leu Asp Gln Ala Lys Thr Gln
1745                1750                1755                1760
Ile Gly Met Thr Glu Ser Leu Leu Lys Ala Leu Ser Pro Ser Asp Ser
                1765                1770                1775    
Leu Glu Ile Phe Thr Lys Leu Glu Glu Ile Gln Gln Gln Ile Leu Gln
            1780                1785                1790        
Gln Lys His Ser Met Ile Leu Leu Glu Asn Gln Ile Gly Cys Leu Thr
        1795                1800                1805            
Pro Glu Leu Ser Glu Leu Lys Lys Gln Tyr Glu Ser Val Ser Asp Leu
    1810                1815                1820                
Phe Asn Thr Lys Lys Ser Val Leu Gln Asp His Phe Ser Lys Leu Leu
1825                1830                1835                1840
Asn Asp Gln Cys Lys Asn Phe Asn Asp Trp Phe Ser Asn Ile Lys Val
                1845                1850                1855    
Asn Leu Lys Glu Cys Phe Glu Ser Ser Glu Thr Lys Lys Ser Val Glu
            1860                1865                1870        
Gln Lys Leu Gln Lys Leu Ser Asp Phe Leu Thr Leu Glu Gly Arg Asn
        1875                1880                1885            
Ser Lys Ile Lys Gln Val Asp Ser Val Leu Lys His Val Lys Lys His
    1890                1895                1900                
Leu Pro Lys Ala His Val Lys Glu Leu Ile Ser Trp Leu Val Gly Gln
1905                1910                1915                1920
Glu Phe Glu Leu Glu Lys Met Glu Ser Ile Cys Gln Ala Arg Ala Lys
                1925                1930                1935    
Glu Leu Glu Asp Ser Leu Gln Gln Leu Leu Arg Leu Gln Asp Asp His
            1940                1945                1950        
Arg Asn Leu Arg Lys Trp Leu Thr Asn Gln Glu Glu Lys Trp Lys Gly
        1955                1960                1965            
Met Glu Glu Pro Gly Glu Lys Thr Glu Leu Phe Cys Gln Ala Leu Ala
    1970                1975                1980                
Arg Lys Arg Glu Gln Phe Glu Ser Val Ala Gln Leu Asn Asn Ser Leu
1985                1990                1995                2000
Lys Glu Tyr Gly Phe Thr Glu Glu Glu Glu Ile Ile Met Glu Ala Thr
                2005                2010                2015    
Cys Leu Met Asp Arg Tyr Gln Thr Leu Leu Arg Gln Leu Ser Glu Ile
            2020                2025                2030        
Glu Glu Glu Asp Lys Leu Leu Pro Thr Glu Asp Gln Ser Phe Asn Asp
        2035                2040                2045            
Leu Ala His Asp Val Ile His Trp Ile Lys Glu Ile Lys Glu Ser Leu
    2050                2055                2060                
Met Val Leu Asn Ser Ser Glu Gly Lys Met Pro Leu Glu Glu Arg Ile
2065                2070                2075                2080
Gln Lys Ile Lys Glu Ile Ile Leu Leu Lys Pro Glu Gly Asp Ala Arg
                2085                2090                2095    
Ile Glu Thr Ile Met Lys Gln Ala Glu Ser Ser Glu Ala Pro Leu Val
            2100                2105                2110        
Gln Lys Thr Leu Thr Asp Ile Ser Asn Gln Trp Asp Asn Thr Leu His
        2115                2120                2125            
Leu Ala Ser Thr Tyr Leu Ser His Gln Glu Lys Leu Leu Leu Glu Gly
    2130                2135                2140                
Glu Lys Tyr Leu Gln Ser Lys Glu Asp Leu Arg Leu Met Leu Ile Glu
2145                2150                2155                2160
Leu Lys Lys Lys Gln Glu Ala Gly Phe Ala Leu Gln His Gly Leu Gln
                2165                2170                2175    
Glu Lys Lys Ala Gln Leu Lys Ile Tyr Lys Lys Phe Leu Lys Lys Ala
            2180                2185                2190        
Gln Asp Leu Thr Ser Leu Leu Lys Glu Leu Lys Ser Gln Gly Asn Tyr
        2195                2200                2205            
Leu Leu Glu Cys Thr Lys Asn Pro Ser Phe Ser Glu Glu Pro Trp Leu
    2210                2215                2220                
Glu Ile Lys His Leu His Glu Ser Leu Leu Gln Gln Leu Gln Asp Ser
2225                2230                2235                2240
Val Gln Asn Leu Asp Gly His Val Arg Glu His Asp Ser Tyr Gln Val
                2245                2250                2255    
Cys Val Thr Asp Leu Asn Thr Thr Leu Asp Asn Phe Ser Lys Glu Phe
            2260                2265                2270        
Val Ser Phe Ser Asp Lys Pro Val Asp Gln Ile Ala Val Glu Glu Lys
        2275                2280                2285            
Leu Gln Lys Leu Gln Glu Leu Glu Asn Arg Leu Ser Leu Gln Asp Gly
    2290                2295                2300                
Thr Leu Lys Lys Ile Leu Ala Leu Ala Lys Ser Val Lys Gln Asn Thr
2305                2310                2315                2320
Ser Ser Val Gly Gln Lys Ile Ile Lys Asp Asp Ile Lys Ser Leu Gln
                2325                2330                2335    
Cys Lys Gln Lys Asp Leu Glu Asn Arg Leu Ala Ser Ala Lys Gln Glu
            2340                2345                2350        
Met Glu Cys Cys Leu Asn Ser Ile Leu Lys Ser Lys Arg Ser Thr Glu
        2355                2360                2365            
Lys Lys Gly Lys Phe Thr Leu Pro Gly Arg Glu Lys Gln Ala Thr Ser
    2370                2375                2380                
Asp Val Gln Glu Ser Thr Gln Glu Ser Ala Ala Val Glu Lys Leu Glu
2385                2390                2395                2400
Glu Asp Trp Glu Ile Asn Lys Asp Ser Ala Val Glu Met Ala Met Ser
                2405                2410                2415    
Lys Gln Leu Ser Leu Asn Ala Gln Glu Ser Met Lys Asn Thr Glu Asp
            2420                2425                2430        
Glu Arg Lys Val Asn Glu Leu Gln Asn Gln Pro Leu Glu Leu Asp Thr
        2435                2440                2445            
Met Leu Arg Asn Glu Gln Leu Glu Glu Ile Glu Lys Leu Tyr Thr Gln
    2450                2455                2460                
Leu Glu Ala Lys Lys Ala Ala Ile Lys Pro Leu Glu Gln Thr Glu Cys
2465                2470                2475                2480
Leu Asn Lys Thr Glu Thr Gly Ala Leu Val Leu His Asn Ile Gly Tyr
                2485                2490                2495    
Ser Ala Gln His Leu Asp Asn Leu Leu Gln Ala Leu Ile Thr Leu Lys
            2500                2505                2510        
Lys Asn Lys Glu Ser Gln Tyr Cys Val Leu Arg Asp Phe Gln Glu Tyr
        2515                2520                2525            
Leu Ala Ala Val Glu Ser Ser Met Lys Ala Leu Leu Thr Asp Lys Glu
    2530                2535                2540                
Ser Leu Lys Val Gly Pro Leu Asp Ser Val Thr Tyr Leu Asp Lys Ile
2545                2550                2555                2560
Lys Lys Phe Ile Ala Ser Ile Glu Lys Glu Lys Asp Ser Leu Gly Asn
                2565                2570                2575    
Leu Lys Ile Lys Trp Glu Asn Leu Ser Asn His Val Thr Asp Met Asp
            2580                2585                2590        
Lys Lys Leu Leu Glu Ser Gln Ile Lys Gln Leu Glu His Gly Trp Glu
        2595                2600                2605            
Gln Val Glu Gln Gln Ile Gln Lys Lys Tyr Ser Gln Gln Val Val Glu
    2610                2615                2620                
Tyr Asp Glu Phe Thr Thr Leu Met Asn Lys Val Gln Asp Thr Glu Ile
2625                2630                2635                2640
Ser Leu Gln Gln Gln Gln Gln His Leu Gln Leu Arg Leu Lys Ser Pro
                2645                2650                2655    
Glu Glu Arg Ala Gly Asn Gln Ser Met Ile Ala Leu Thr Thr Asp Leu
            2660                2665                2670        
Gln Ala Thr Lys His Gly Phe Ser Val Leu Lys Gly Gln Ala Glu Leu
        2675                2680                2685            
Gln Met Lys Arg Ile Trp Gly Glu Lys Glu Lys Lys Asn Leu Glu Asp
    2690                2695                2700                
Gly Ile Asn Asn Leu Lys Lys Gln Trp Glu Thr Leu Glu Pro Leu His
2705                2710                2715                2720
Leu Glu Ala Glu Asn Gln Ile Lys Lys Cys Asp Ile Arg Asn Lys Met
                2725                2730                2735    
Lys Glu Thr Ile Leu Trp Ala Lys Asn Leu Leu Gly Glu Leu Asn Pro
            2740                2745                2750        
Ser Ile Pro Leu Leu Pro Asp Asp Ile Leu Ser Gln Ile Arg Lys Cys
        2755                2760                2765            
Lys Val Thr His Asp Gly Ile Leu Ala Arg Gln Gln Ser Val Glu Ser
    2770                2775                2780                
Leu Ala Glu Glu Val Lys Asp Lys Val Pro Ser Leu Thr Thr Tyr Glu
2785                2790                2795                2800
Gly Ser Asp Leu Asn Asn Thr Leu Glu Asp Leu Arg Asn Gln Tyr Gln
                2805                2810                2815    
Met Leu Val Leu Lys Ser Thr Gln Arg Ser Gln Gln Leu Glu Phe Lys
            2820                2825                2830        
Leu Glu Glu Arg Ser Asn Phe Phe Ala Ile Ile Arg Lys Phe Gln Leu
        2835                2840                2845            
Met Val Gln Glu Ser Glu Thr Leu Ile Ile Pro Arg Val Glu Thr Ala
    2850                2855                2860                
Ala Thr Glu Ala Glu Leu Lys His His His Val Thr Leu Glu Ala Ser
2865                2870                2875                2880
Gln Lys Glu Leu Gln Glu Ile Asp Ser Gly Ile Ser Thr His Leu Gln
                2885                2890                2895    
Glu Leu Thr Asn Ile Tyr Glu Glu Leu Asn Val Phe Glu Arg Leu Phe
            2900                2905                2910        
Leu Glu Asp Gln Leu Lys Asn Leu Lys Ile Arg Thr Asn Arg Ile Gln
        2915                2920                2925            
Arg Phe Ile Gln Asn Thr Cys Asn Glu Val Glu His Lys Ile Lys Phe
    2930                2935                2940                
Cys Arg Gln Phe His Glu Lys Thr Ser Ala Leu Gln Glu Glu Ala Asp
2945                2950                2955                2960
Ser Ile Gln Arg Asn Glu Leu Leu Leu Asn Gln Glu Val Asn Lys Gly
                2965                2970                2975    
Val Lys Glu Glu Ile Tyr Asn Leu Lys Asp Arg Leu Thr Ala Ile Lys
            2980                2985                2990        
Cys Cys Ile Leu Gln Val Leu Lys Leu Lys Lys Val Phe Asp Tyr Ile
        2995                3000                3005            
Gly Leu Asn Trp Asp Phe Ser Gln Leu Asp Gln Leu Gln Thr Gln Val
    3010                3015                3020                
Phe Glu Lys Glu Lys Glu Leu Glu Glu Lys Ile Lys Gln Leu Asp Thr
3025                3030                3035                3040
Phe Glu Glu Glu His Gly Lys Tyr Gln Ala Leu Leu Ser Lys Met Arg
                3045                3050                3055    
Ala Ile Asp Leu Gln Ile Lys Lys Met Thr Glu Val Val Leu Lys Ala
            3060                3065                3070        
Pro Asp Ser Ser Pro Glu Ser Arg Arg Leu Asn Ala Gln Ile Leu Ser
        3075                3080                3085            
Gln Arg Ile Glu Lys Ala Lys Cys Leu Cys Asp Glu Ile Ile Lys Lys
    3090                3095                3100                
Leu Asn Glu Asn Lys Thr Phe Asp Asp Ser Phe Lys Glu Lys Glu Ile
3105                3110                3115                3120
Leu Gln Ile Lys Leu Asn Ala Glu Glu Asn Asp Lys Leu Tyr Lys Val
                3125                3130                3135    
Leu Gln Asn Met Val Leu Glu Leu Ser Pro Lys Glu Leu Asp Glu Lys
            3140                3145                3150        
Asn Cys Gln Asp Lys Leu Glu Thr Ser Leu His Val Leu Asn Gln Ile
        3155                3160                3165            
Lys Ser Gln Leu Gln Gln Pro Leu Leu Ile Asn Leu Glu Ile Lys His
    3170                3175                3180                
Ile Gln Asn Glu Lys Asp Asn Cys Glu Ala Phe Gln Glu Gln Val Trp
3185                3190                3195                3200
Ala Glu Met Cys Ser Ile Lys Ala Val Thr Ala Ile Glu Lys Gln Arg
                3205                3210                3215    
Glu Glu Asn Ser Ser Glu Ala Ser Asp Val Glu Thr Lys Leu Arg Glu
            3220                3225                3230        
Phe Glu Asp Leu Gln Met Gln Leu Asn Thr Ser Ile Asp Leu Arg Thr
        3235                3240                3245            
Asn Val Leu Asn Asp Ala Tyr Glu Asn Leu Thr Arg Tyr Lys Glu Ala
    3250                3255                3260                
Val Thr Arg Ala Val Glu Ser Ile Thr Ser Leu Glu Ala Ile Ile Ile
3265                3270                3275                3280
Pro Tyr Arg Val Asp Val Gly Asn Pro Glu Glu Ser Leu Glu Met Pro
                3285                3290                3295    
Leu Arg Lys Gln Glu Glu Leu Glu Ser Thr Val Ala His Ile Gln Asp
            3300                3305                3310        
Leu Thr Glu Lys Leu Gly Met Ile Ser Ser Pro Glu Ala Lys Leu Gln
        3315                3320                3325            
Leu Gln Tyr Thr Leu Gln Glu Leu Val Ser Lys Asn Ser Ala Met Lys
    3330                3335                3340                
Glu Ala Phe Lys Ala Gln Glu Thr Glu Ala Glu Arg Tyr Leu Glu Asn
3345                3350                3355                3360
Tyr Lys Cys Tyr Arg Lys Met Glu Glu Asp Ile Tyr Thr Asn Leu Ser
                3365                3370                3375    
Lys Met Glu Thr Val Leu Gly Gln Ser Met Ser Ser Leu Pro Leu Ser
            3380                3385                3390        
Tyr Arg Glu Ala Leu Glu Arg Leu Glu Gln Ser Lys Ala Leu Val Ser
        3395                3400                3405            
Asn Leu Ile Ser Thr Lys Glu Glu Leu Met Lys Leu Arg Gln Ile Leu
    3410                3415                3420                
Arg Leu Leu Arg Leu Arg Cys Thr Glu Asn Asp Gly Ile Cys Leu Leu
3425                3430                3435                3440
Lys Ile Val Ser Ala Leu Trp Glu Lys Trp Leu Ser Leu Leu Glu Ala
                3445                3450                3455    
Ala Lys Glu Trp Glu Met Trp Cys Glu Glu Leu Lys Gln Glu Trp Lys
            3460                3465                3470        
Phe Val Ser Glu Glu Ile Glu Arg Glu Ala Ile Ile Leu Asp Asn Leu
        3475                3480                3485            
Gln Glu Glu Leu Pro Glu Ile Ser Lys Thr Lys Glu Ala Ala Thr Thr
    3490                3495                3500                
Glu Glu Leu Ser Glu Leu Leu Asp Cys Leu Cys Gln Tyr Gly Glu Asn
3505                3510                3515                3520
Val Glu Lys Gln Gln Leu Leu Leu Thr Leu Leu Leu Gln Arg Ile Arg
                3525                3530                3535    
Ser Ile Gln Asn Val Pro Glu Ser Ser Gly Ala Val Glu Thr Val Pro
            3540                3545                3550        
Ala Phe Gln Glu Ile Thr Ser Met Lys Glu Arg Cys Asn Lys Leu Leu
        3555                3560                3565            
Gln Lys Val Gln Lys Asn Lys Glu Leu Val Gln Thr Glu Ile Gln Glu
    3570                3575                3580                
Arg His Ser Phe Thr Lys Glu Ile Ile Ala Leu Lys Asn Phe Phe Gln
3585                3590                3595                3600
Gln Thr Thr Thr Ser Phe Gln Asn Met Ala Phe Gln Asp His Pro Glu
                3605                3610                3615    
Lys Ser Glu Gln Phe Glu Glu Leu Gln Ser Ile Leu Lys Lys Gly Lys
            3620                3625                3630        
Leu Thr Phe Glu Asn Ile Met Glu Lys Leu Arg Ile Lys Tyr Ser Glu
        3635                3640                3645            
Met Tyr Thr Ile Val Pro Ala Glu Ile Glu Ser Gln Val Glu Glu Cys
    3650                3655                3660                
Arg Lys Ala Leu Glu Asp Ile Asp Glu Lys Ile Ser Asn Glu Val Leu
3665                3670                3675                3680
Lys Ser Ser Pro Ser Tyr Ala Met Arg Arg Lys Ile Glu Glu Ile Asn
                3685                3690                3695    
Asn Gly Leu His Asn Val Glu Lys Met Leu Gln Gln Lys Ser Lys Asn
            3700                3705                3710        
Ile Glu Lys Ala Gln Glu Ile Gln Lys Lys Met Trp Asp Glu Leu Asp
        3715                3720                3725            
Leu Trp His Ser Lys Leu Asn Glu Leu Asp Ser Glu Val Gln Asp Ile
    3730                3735                3740                
Val Glu Gln Asp Pro Gly Gln Ala Gln Glu Trp Met Asp Asn Leu Met
3745                3750                3755                3760
Ile Pro Phe Gln Gln Tyr Gln Gln Val Ser Gln Arg Ala Glu Cys Arg
                3765                3770                3775    
Thr Ser Gln Leu Asn Lys Ala Thr Val Lys Met Glu Glu Tyr Ser Asp
            3780                3785                3790        
Leu Leu Lys Ser Thr Glu Ala Trp Ile Glu Asn Thr Ser His Leu Leu
        3795                3800                3805            
Ala Asn Pro Ala Asp Tyr Asp Ser Leu Arg Thr Leu Ser His His Ala
    3810                3815                3820                
Ser Thr Val Gln Met Ala Leu Glu Asp Ser Glu Gln Lys His Asn Leu
3825                3830                3835                3840
Leu His Ser Ile Phe Met Asp Leu Glu Asp Leu Ser Ile Ile Phe Glu
                3845                3850                3855    
Thr Asp Glu Leu Thr Gln Ser Ile Gln Glu Leu Ser Asn Gln Val Thr
            3860                3865                3870        
Ala Leu Gln Gln Lys Ile Met Glu Ser Leu Pro Gln Ile Gln Arg Met
        3875                3880                3885            
Ala Asp Asp Val Val Ala Ile Glu Ser Glu Val Lys Ser Met Glu Lys
    3890                3895                3900                
Arg Val Ser Lys Ile Lys Thr Ile Leu Leu Ser Lys Glu Ile Phe Asp
3905                3910                3915                3920
Phe Ser Pro Glu Glu His Leu Lys His Gly Glu Val Ile Leu Glu Asn
                3925                3930                3935    
Ile Arg Pro Met Lys Lys Thr Ile Ala Glu Ile Val Ser Tyr Gln Val
            3940                3945                3950        
Glu Leu Arg Leu Pro Gln Thr Gly Met Lys Pro Leu Pro Val Phe Gln
        3955                3960                3965            
Arg Thr Asn Gln Leu Leu Gln Asp Ile Lys Leu Leu Glu Asn Val Thr
    3970                3975                3980                
Gln Glu Gln Asn Glu Leu Leu Lys Val Val Ile Lys Gln Thr Asn Glu
3985                3990                3995                4000
Gln Asp Glu Glu Ile Glu Asn Leu Lys Gln Ile Leu Asn Asn Tyr Ser
                4005                4010                4015    
Ala Gln Phe Ser Leu Glu His Met Ser Pro Asp Gln Ala Asp Lys Leu
            4020                4025                4030        
Pro Gln Leu Gln Gly Glu Ile Glu Arg Met Glu Lys Gln Ile Leu Ser
        4035                4040                4045            
Leu Asn Gln Arg Lys Glu Asp Leu Leu Val Asp Leu Lys Ala Thr Val
    4050                4055                4060                
Leu Asn Leu His Gln His Leu Lys Gln Glu Gln Glu Gly Val Glu Arg
4065                4070                4075                4080
Asp Arg Leu Pro Ala Val Thr Ser Glu Glu Gly Gly Val Ala Glu Arg
                4085                4090                4095    
Asp Ala Ser Glu Arg Lys Leu Asn Arg Arg Gly Ser Met Ser Tyr Leu
            4100                4105                4110        
Ala Ala Val Glu Glu Glu Val Glu Glu Ser Ser Val Lys Ser Asp Asn
        4115                4120                4125            
Gly Asp Glu Lys Ala Glu Pro Ser Pro Gln Ser Trp Ser Ser Leu Trp
    4130                4135                4140                
Lys His Asp Lys Asp Met Glu Glu Asp Arg Ala Ser Ser Ser Ser Gly
4145                4150                4155                4160
Thr Ile Val Gln Glu Ala Tyr Gly Lys Ile Ser Thr Ser Asp Asn Ser
                4165                4170                4175    
Met Ala Gln Ile Leu Thr Pro Asp Ser Leu Asn Thr Glu Gln Gly Pro
            4180                4185                4190        
Glu Cys Ser Leu Arg Pro Asn Gln Thr Glu Glu Gly Thr Thr Pro Pro
        4195                4200                4205            
Ile Glu Ala Asp Thr Leu Asp Ser Ser Asp Ala Gln Gly Gly Leu Glu
    4210                4215                4220                
Pro Arg Val Glu Lys Thr Arg Pro Glu Pro Thr Glu Val Leu His Ala
4225                4230                4235                4240
Cys Lys Thr Gln Val Ala Glu Leu Glu Leu Trp Leu Gln Gln Ala Asn
                4245                4250                4255    
Val Ala Val Glu Pro Glu Thr Leu Asn Ala Asp Met Gln Gln Val Leu
            4260                4265                4270        
Glu Gln Gln Leu Val Gly Cys Gln Ala Met Leu Thr Glu Ile Glu His
        4275                4280                4285            
Lys Val Ala Phe Leu Leu Glu Thr Cys Lys Asp Gln Gly Leu Gly Asp
    4290                4295                4300                
Asn Gly Ala Thr Gln His Glu Ala Glu Ala Leu Ser Leu Lys Leu Lys
4305                4310                4315                4320
Thr Val Lys Cys Asn Leu Glu Lys Val Gln Met Met Leu Gln Glu Lys
                4325                4330                4335    
His Ser Glu Asp Gln His Pro Thr Ile Leu Lys Lys Ser Ser Glu Pro
            4340                4345                4350        
Glu His Gln Glu Ala Leu Gln Pro Val Asn Leu Ser Glu Leu Glu Ser
        4355                4360                4365            
Ile Val Thr Glu Arg Pro Gln Phe Ser Arg Gln Lys Asp Phe Gln Gln
    4370                4375                4380                
Gln Gln Val Leu Glu Leu Lys Pro Met Glu Gln Lys Asp Phe Ile Lys
4385                4390                4395                4400
Phe Ile Glu Phe Asn Ala Lys Lys Met Trp Pro Gln Tyr Cys Gln His
                4405                4410                4415    
Asp Asn Asp Thr Thr Gln Glu Ser Ser Ala Ser Asn Gln Ala Ser Ser
            4420                4425                4430        
Pro Glu Asn Asp Val Pro Asp Ser Ile Leu Ser Pro Gln Gly Gln Asn
        4435                4440                4445            
Gly Asp Lys Trp Gln Tyr Leu His His Glu Leu Ser Ser Lys Ile Lys
    4450                4455                4460                
Leu Pro Leu Pro Gln Leu Val Glu Pro Gln Val Ser Thr Asn Met Gly
4465                4470                4475                4480
Ile Leu Pro Ser Val Thr Met Tyr Asn Phe Arg Tyr Pro Thr Thr Glu
                4485                4490                4495    
Glu Leu Lys Thr Tyr Thr Thr Gln Leu Glu Asp Leu Arg Gln Glu Ala
            4500                4505                4510        
Ser Asn Leu Gln Thr Gln Glu Asn Met Thr Glu Glu Ala Tyr Ile Asn
        4515                4520                4525            
Leu Asp Lys Lys Leu Phe Glu Leu Phe Leu Thr Leu Ser Gln Cys Leu
    4530                4535                4540                
Ser Ser Val Glu Glu Met Leu Glu Met Pro Arg Leu Tyr Arg Glu Asp
4545                4550                4555                4560
Gly Ser Gly Gln Gln Val His Tyr Glu Thr Leu Ala Leu Glu Leu Lys
                4565                4570                4575    
Lys Leu Tyr Leu Ala Leu Ser Asp Lys Lys Gly Asp Leu Leu Lys Ala
            4580                4585                4590        
Met Thr Trp Pro Gly Glu Asn Thr Asn Leu Leu Leu Glu Cys Phe Asp
        4595                4600                4605            
Asn Leu Gln Val Cys Leu Glu His Thr Gln Ala Ala Ala Val Cys Arg
    4610                4615                4620                
Ser Lys Ser Leu Lys Ala Gly Leu Asp Tyr Asn Arg Ser Tyr Gln Asn
4625                4630                4635                4640
Glu Ile Lys Arg Leu Tyr His Gln Leu Ile Lys Ser Lys Thr Ser Leu
                4645                4650                4655    
Gln Gln Ser Leu Asn Glu Ile Ser Gly Gln Ser Val Ala Glu Gln Leu
            4660                4665                4670        
Gln Lys Ala Asp Ala Tyr Thr Val Glu Leu Glu Asn Ala Glu Ser Arg
        4675                4680                4685            
Val Ala Lys Leu Arg Asp Glu Gly Glu Arg Leu His Leu Pro Tyr Ala
    4690                4695                4700                
Leu Leu Gln Glu Val Tyr Lys Leu Glu Asp Val Leu Asp Ser Met Trp
4705                4710                4715                4720
Gly Met Leu Arg Ala Arg Tyr Thr Glu Leu Ser Ser Pro Phe Val Thr
                4725                4730                4735    
Glu Ser Gln Gln Asp Ala Leu Leu Gln Gly Met Val Glu Leu Val Lys
            4740                4745                4750        
Ile Gly Lys Glu Lys Leu Ala His Gly His Leu Lys Gln Thr Lys Ser
        4755                4760                4765            
Lys Val Ala Leu Gln Ala Gln Ile Glu Asn His Lys Val Phe Phe Gln
    4770                4775                4780                
Lys Leu Val Ala Asp Met Leu Leu Ile Gln Ala Tyr Ser Ala Lys Ile
4785                4790                4795                4800
Leu Pro Ser Leu Leu Gln Asn Arg Glu Thr Phe Trp Ala Glu Gln Val
                4805                4810                4815    
Thr Glu Val Lys Ile Leu Glu Glu Lys Ser Arg Gln Cys Gly Met Lys
            4820                4825                4830        
Leu Gln Ser Leu Leu Gln Lys Trp Glu Glu Phe Asp Glu Asn Tyr Ala
        4835                4840                4845            
Ser Leu Glu Lys Asp Leu Glu Ile Leu Ile Ser Thr Leu Pro Ser Val
    4850                4855                4860                
Ser Leu Val Glu Glu Thr Glu Glu Arg Leu Val Glu Arg Ile Ser Phe
4865                4870                4875                4880
Tyr Gln Gln Ile Lys Arg Asn Ile Gly Gly Lys His Ala Arg Leu Tyr
                4885                4890                4895    
Gln Thr Leu Asn Glu Gly Lys Gln Leu Val Ala Ser Val Ser Cys Pro
            4900                4905                4910        
Glu Leu Glu Gly Gln Ile Ala Lys Leu Glu Glu Gln Trp Leu Ser Leu
        4915                4920                4925            
Asn Lys Lys Ile Asp His Glu Leu His Arg Leu Gln Ala Leu Leu Lys
    4930                4935                4940                
His Leu Leu Ser Tyr Asn Arg Asp Ser Asp Gln Leu Thr Lys Trp Leu
4945                4950                4955                4960
Glu Ser Ser Gln His Thr Leu Asn Tyr Trp Lys Glu Gln Ser Leu Asn
                4965                4970                4975    
Val Ser Gln Asp Leu Asp Thr Ile Arg Ser Asn Ile Asn Asn Phe Phe
            4980                4985                4990        
Glu Phe Ser Lys Glu Val Asp Glu Lys Ser Ser Leu Lys Thr Ala Val
        4995                5000                5005            
Ile Ser Ile Gly Asn Gln Leu Leu His Leu Lys Glu Thr Asp Thr Ala
    5010                5015                5020                
Thr Leu Arg Ala Ser Leu Ala Gln Phe Glu Gln Lys Trp Thr Met Leu
5025                5030                5035                5040
Ile Thr Gln Leu Pro Asp Ile Gln Glu Lys Leu His Gln Leu Gln Met
                5045                5050                5055    
Glu Lys Leu Pro Ser Arg Lys Ala Ile Thr Glu Met Ile Ser Trp Met
            5060                5065                5070        
Asn Asn Val Glu His Gln Thr Ser Asp Glu Asp Ser Val His Ser Pro
        5075                5080                5085            
Ser Ser Ala Ser Gln Val Lys His Leu Leu Gln Lys His Lys Glu Phe
    5090                5095                5100                
Arg Met Glu Met Asp Tyr Lys Gln Trp Ile Val Asp Phe Val Asn Gln
5105                5110                5115                5120
Ser Leu Leu Gln Leu Ser Thr Cys Asp Val Glu Ser Lys Arg Tyr Glu
                5125                5130                5135    
Arg Thr Glu Phe Ala Glu His Leu Gly Glu Met Asn Arg Gln Trp His
            5140                5145                5150        
Arg Val His Gly Met Leu Asn Arg Lys Ile Gln His Leu Glu Gln Leu
        5155                5160                5165            
Leu Glu Ser Ile Thr Glu Ser Glu Asn Lys Ile Gln Ile Leu Asn Asn
    5170                5175                5180                
Trp Leu Glu Ala Gln Glu Glu Arg Leu Lys Thr Leu Gln Lys Pro Glu
5185                5190                5195                5200
Ser Val Ile Ser Val Gln Lys Leu Leu Leu Asp Cys Gln Asp Ile Glu
                5205                5210                5215    
Asn Gln Leu Ala Ile Lys Ser Lys Ala Leu Asp Glu Leu Lys Gln Ser
            5220                5225                5230        
Tyr Leu Thr Leu Glu Ser Gly Ala Val Pro Leu Leu Glu Asp Thr Ala
        5235                5240                5245            
Ser Arg Ile Asp Glu Leu Phe Gln Lys Arg Ser Ser Val Leu Thr Gln
    5250                5255                5260                
Val Asn Gln Leu Lys Thr Ser Met Gln Ser Val Leu Gln Glu Trp Lys
5265                5270                5275                5280
Ile Tyr Asp Gln Leu Tyr Asp Glu Val Asn Met Met Thr Ile Arg Phe
                5285                5290                5295    
Trp Tyr Cys Met Glu His Ser Lys Pro Val Val Leu Ser Leu Glu Thr
            5300                5305                5310        
Leu Arg Cys Gln Val Glu Asn Leu Gln Ser Leu Gln Asp Glu Ala Glu
        5315                5320                5325            
Ser Ser Glu Gly Ser Trp Glu Lys Leu Gln Glu Val Ile Gly Lys Leu
    5330                5335                5340                
Lys Gly Leu Cys Pro Ser Val Ala Glu Ile Ile Glu Glu Lys Cys Gln
5345                5350                5355                5360
Asn Thr His Lys Arg Trp Thr Gln Val Asn Gln Ala Ile Ala Asp Gln
                5365                5370                5375    
Leu Gln Lys Ala Gln Ser Leu Leu Gln Leu Trp Lys Ala Tyr Ser Asn
            5380                5385                5390        
Ala His Gly Glu Ala Ala Ala Arg Leu Lys Gln Gln Glu Ala Lys Phe
        5395                5400                5405            
Gln Gln Leu Ala Asn Ile Ser Met Ser Gly Asn Asn Leu Ala Glu Ile
    5410                5415                5420                
Leu Pro Pro Ala Leu Gln Asp Ile Lys Glu Leu Gln His Asp Val Gln
5425                5430                5435                5440
Lys Thr Lys Glu Ala Phe Leu Gln Asn Ser Ser Val Leu Asp Arg Leu
                5445                5450                5455    
Pro Gln Pro Ala Glu Ser Ser Thr His Met Leu Leu Pro Gly Pro Leu
            5460                5465                5470        
His Ser Leu Gln Arg Ala Ala Tyr Leu Glu Lys Met Leu Leu Val Lys
        5475                5480                5485            
Ala Asn Glu Phe Glu Phe Val Leu Ser Gln Phe Lys Asp Phe Gly Val
    5490                5495                5500                
Arg Leu Glu Ser Leu Lys Gly Leu Ile Met His Glu Glu Glu Asn Leu
5505                5510                5515                5520
Asp Arg Leu His Gln Gln Glu Lys Glu Asn Pro Asp Ser Phe Leu Asn
                5525                5530                5535    
His Val Leu Ala Leu Thr Ala Gln Ser Pro Asp Ile Glu His Leu Asn
            5540                5545                5550        
Glu Val Ser Leu Lys Leu Pro Leu Ser Asp Val Ala Val Lys Thr Leu
        5555                5560                5565            
Gln Asn Met Asn Arg Gln Trp Ile Arg Ala Thr Ala Thr Ala Leu Glu
    5570                5575                5580                
Arg Cys Ser Glu Leu Gln Gly Ile Gly Leu Asn Glu Lys Phe Leu Tyr
5585                5590                5595                5600
Cys Cys Glu Lys Trp Ile Gln Leu Leu Glu Lys Ile Glu Glu Ala Leu
                5605                5610                5615    
Lys Val Asp Val Ala Asn Ser Leu Pro Glu Leu Leu Glu Gln Gln Lys
            5620                5625                5630        
Thr Tyr Lys Met Leu Glu Ala Glu Val Ser Ile Asn Gln Thr Ile Ala
        5635                5640                5645            
Asp Ser Tyr Val Thr Gln Ser Leu Gln Leu Leu Asp Thr Thr Glu Ile
    5650                5655                5660                
Glu Asn Arg Pro Glu Phe Ile Thr Glu Phe Ser Lys Leu Thr Asp Arg
5665                5670                5675                5680
Trp Gln Asn Ala Val Gln Gly Val Arg Gln Arg Lys Gly Asp Val Asp
                5685                5690                5695    
Gly Leu Val Arg Gln Trp Gln Asp Phe Thr Thr Ser Val Glu Asn Leu
            5700                5705                5710        
Phe Arg Phe Leu Thr Asp Thr Ser His Leu Leu Ser Ala Val Lys Gly
        5715                5720                5725            
Gln Glu Arg Phe Ser Leu Tyr Gln Thr Arg Ser Leu Ile His Glu Leu
    5730                5735                5740                
Lys Asn Lys Glu Ile His Phe Gln Arg Arg Arg Thr Thr Cys Ala Leu
5745                5750                5755                5760
Thr Leu Glu Ala Gly Glu Lys Leu Leu Leu Thr Thr Asp Leu Lys Thr
                5765                5770                5775    
Lys Glu Ser Val Gly Arg Arg Ile Ser Gln Leu Gln Asp Ser Trp Lys
            5780                5785                5790        
Asp Met Glu Pro Gln Leu Ala Glu Met Ile Lys Gln Phe Gln Ser Thr
        5795                5800                5805            
Val Glu Thr Trp Asp Gln Cys Glu Lys Lys Ile Lys Glu Leu Lys Ser
    5810                5815                5820                
Arg Leu Gln Val Leu Lys Ala Gln Ser Glu Asp Pro Leu Pro Glu Leu
5825                5830                5835                5840
His Glu Asp Leu His Asn Glu Lys Glu Leu Ile Lys Glu Leu Glu Gln
                5845                5850                5855    
Ser Leu Ala Ser Trp Thr Gln Asn Leu Lys Glu Leu Gln Thr Met Lys
            5860                5865                5870        
Ala Asp Leu Thr Arg His Val Leu Val Glu Asp Val Met Val Leu Lys
        5875                5880                5885            
Glu Gln Ile Glu His Leu His Arg Gln Trp Glu Asp Leu Cys Leu Arg
    5890                5895                5900                
Val Ala Ile Arg Lys Gln Glu Ile Glu Asp Arg Leu Asn Thr Trp Val
5905                5910                5915                5920
Val Phe Asn Glu Lys Asn Lys Glu Leu Cys Ala Trp Leu Val Gln Met
                5925                5930                5935    
Glu Asn Lys Val Leu Gln Thr Ala Asp Ile Ser Ile Glu Glu Met Ile
            5940                5945                5950        
Glu Lys Leu Gln Lys Asp Cys Met Glu Glu Ile Asn Leu Phe Ser Glu
        5955                5960                5965            
Asn Lys Leu Gln Leu Lys Gln Met Gly Asp Gln Leu Ile Lys Ala Ser
    5970                5975                5980                
Asn Lys Ser Arg Ala Ala Glu Ile Asp Asp Lys Leu Asn Lys Ile Asn
5985                5990                5995                6000
Asp Arg Trp Gln His Leu Phe Asp Val Ile Gly Ser Arg Val Lys Lys
                6005                6010                6015    
Leu Lys Glu Thr Phe Ala Phe Ile Gln Gln Leu Asp Lys Asn Met Ser
            6020                6025                6030        
Asn Leu Arg Thr Trp Leu Ala Arg Ile Glu Ser Glu Leu Ser Lys Pro
        6035                6040                6045            
Val Val Tyr Asp Val Cys Asp Asp Gln Glu Ile Gln Lys Arg Leu Ala
    6050                6055                6060                
Glu Gln Gln Asp Leu Gln Arg Asp Ile Glu Gln His Ser Ala Gly Val
6065                6070                6075                6080
Glu Ser Val Phe Asn Ile Cys Asp Val Leu Leu His Asp Ser Asp Ala
                6085                6090                6095    
Cys Ala Asn Glu Thr Glu Cys Asp Ser Ile Gln Gln Thr Thr Arg Ser
            6100                6105                6110        
Leu Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met Glu Arg Arg
        6115                6120                6125            
Met Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe Leu Asp Asp
    6130                6135                6140                
Tyr Ser Arg Phe Glu Asp Trp Leu Lys Ser Ala Glu Arg Thr Ala Ala
6145                6150                6155                6160
Cys Pro Asn Ser Ser Glu Val Leu Tyr Thr Ser Ala Lys Glu Glu Leu
                6165                6170                6175    
Lys Arg Phe Glu Ala Phe Gln Arg Gln Ile His Glu Arg Leu Thr Gln
            6180                6185                6190        
Leu Glu Leu Ile Asn Lys Gln Tyr Arg Arg Leu Ala Arg Glu Asn Arg
        6195                6200                6205            
Thr Asp Thr Ala Ser Arg Leu Lys Gln Met Val His Glu Gly Asn Gln
    6210                6215                6220                
Arg Trp Asp Asn Leu Gln Arg Arg Val Thr Ala Val Leu Arg Arg Leu
6225                6230                6235                6240
Arg His Phe Thr Asn Gln Arg Glu Glu Phe Glu Gly Thr Arg Glu Ser
                6245                6250                6255    
Ile Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr Asn Val Glu
            6260                6265                6270        
His Phe Ser Glu Ser Asp Ala Asp Asp Lys Met Arg Gln Leu Asn Gly
        6275                6280                6285            
Phe Gln Gln Glu Ile Thr Leu Asn Thr Asn Lys Ile Asp Gln Leu Ile
    6290                6295                6300                
Val Phe Gly Glu Gln Leu Ile Gln Lys Ser Glu Pro Leu Asp Ala Val
6305                6310                6315                6320
Leu Ile Glu Asp Glu Leu Glu Glu Leu His Arg Tyr Cys Gln Glu Val
                6325                6330                6335    
Phe Gly Arg Val Ser Arg Phe His Arg Arg Leu Thr Ser Cys Thr Pro
            6340                6345                6350        
Gly Leu Glu Asp Glu Lys Glu Ala Ser Glu Asn Glu Thr Asp Met Glu
        6355                6360                6365            
Asp Pro Arg Glu Ile Gln Thr Asp Ser Trp Arg Lys Arg Gly Glu Ser
    6370                6375                6380                
Glu Glu Pro Ser Ser Pro Gln Ser Leu Cys His Leu Val Ala Pro Gly
6385                6390                6395                6400
His Glu Arg Ser Gly Cys Glu Thr Pro Val Ser Val Asp Ser Ile Pro
                6405                6410                6415    
Leu Glu Trp Asp His Thr Gly Asp Val Gly Gly Ser Ser Ser His Glu
            6420                6425                6430        
Glu Asp Glu Glu Gly Pro Tyr Tyr Ser Ala Leu Ser Gly Lys Ser Ile
        6435                6440                6445            
Ser Asp Gly His Ser Trp His Val Pro Asp Ser Pro Ser Cys Pro Glu
    6450                6455                6460                
His His Tyr Lys Gln Met Glu Gly Asp Arg Asn Val Pro Pro Val Pro
6465                6470                6475                6480
Pro Ala Ser Ser Thr Pro Tyr Lys Pro Pro Tyr Gly Lys Leu Leu Leu
                6485                6490                6495    
Pro Pro Gly Thr Asp Gly Gly Lys Glu Gly Pro Arg Val Leu Asn Gly
            6500                6505                6510        
Asn Pro Gln Gln Glu Asp Gly Gly Leu Ala Gly Ile Thr Glu Gln Gln
        6515                6520                6525            
Ser Gly Ala Phe Asp Arg Trp Glu Met Ile Gln Ala Gln Glu Leu His
    6530                6535                6540                
Asn Lys Leu Lys Ile Lys Gln Asn Leu Gln Gln Leu Asn Ser Asp Ile
6545                6550                6555                6560
Ser Ala Ile Thr Thr Trp Leu Lys Lys Thr Glu Ala Glu Leu Glu Met
                6565                6570                6575    
Leu Lys Met Ala Lys Pro Pro Ser Asp Ile Gln Glu Ile Glu Leu Arg
            6580                6585                6590        
Val Lys Arg Leu Gln Glu Ile Leu Lys Ala Phe Asp Thr Tyr Lys Ala
        6595                6600                6605            
Leu Val Val Ser Val Asn Val Ser Ser Lys Glu Phe Leu Gln Thr Glu
    6610                6615                6620                
Ser Pro Glu Ser Thr Glu Leu Gln Ser Arg Leu Arg Gln Leu Ser Leu
6625                6630                6635                6640
Leu Trp Glu Ala Ala Gln Gly Ala Val Asp Ser Trp Arg Gly Gly Leu
                6645                6650                6655    
Arg Gln Ser Leu Met Gln Cys Gln Asp Phe His Gln Leu Ser Gln Asn
            6660                6665                6670        
Leu Leu Leu Trp Leu Ala Ser Ala Lys Asn Arg Arg Gln Lys Ala His
        6675                6680                6685            
Val Thr Asp Pro Lys Ala Asp Pro Arg Ala Leu Leu Glu Cys Arg Arg
    6690                6695                6700                
Glu Leu Met Gln Leu Glu Lys Glu Leu Val Glu Arg Gln Pro Gln Val
6705                6710                6715                6720
Asp Met Leu Gln Glu Ile Ser Asn Ser Leu Leu Ile Lys Gly His Gly
                6725                6730                6735    
Glu Asp Cys Ile Glu Ala Glu Glu Lys Val His Val Ile Glu Lys Lys
            6740                6745                6750        
Leu Lys Gln Leu Arg Glu Gln Val Ser Gln Asp Leu Met Ala Leu Gln
        6755                6760                6765            
Gly Thr Gln Asn Pro Ala Ser Pro Leu Pro Ser Phe Asp Glu Val Asp
    6770                6775                6780                
Ser Gly Asp Gln Pro Pro Ala Thr Ser Val Pro Ala Pro Arg Ala Lys
6785                6790                6795                6800
Gln Phe Arg Ala Val Arg Thr Thr Glu Gly Glu Glu Glu Thr Glu Ser
                6805                6810                6815    
Arg Val Pro Gly Ser Thr Arg Pro Gln Arg Ser Phe Leu Ser Arg Val
            6820                6825                6830        
Val Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Leu Leu Leu
        6835                6840                6845            
Leu Ala Cys Leu Leu Pro Ser Ser Glu Glu Asp Tyr Ser Cys Thr Gln
    6850                6855                6860                
Ala Asn Asn Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr Asn
6865                6870                6875                6880
Gly Pro Pro Pro Thr
                6885


<210> 6871
<211> 284
<212> PRT
<213> Homo sapiens

<400> 6871
Met Pro Arg Tyr Ala Gln Leu Val Met Gly Pro Ala Gly Ser Gly Lys
 1               5                  10                  15      
Ser Thr Tyr Cys Ala Thr Met Val Gln His Cys Glu Ala Leu Asn Arg
            20                  25                  30          
Ser Val Gln Val Val Asn Leu Asp Pro Ala Ala Glu His Phe Asn Tyr
        35                  40                  45              
Ser Val Met Val Asp Ile Arg Glu Leu Ile Glu Val Asp Asp Val Met
    50                  55                  60                  
Glu Asp Asp Ser Leu Arg Phe Gly Pro Asn Gly Gly Leu Val Phe Cys
65                  70                  75                  80  
Met Glu Tyr Phe Ala Asn Asn Phe Asp Trp Leu Glu Asn Cys Leu Gly
                85                  90                  95      
His Val Glu Asp Asp Tyr Ile Leu Phe Asp Cys Pro Gly Gln Ile Glu
            100                 105                 110         
Leu Tyr Thr His Leu Pro Val Met Lys Gln Leu Val Gln Gln Leu Glu
        115                 120                 125             
Gln Trp Glu Phe Arg Val Cys Gly Val Phe Leu Val Asp Ser Gln Phe
    130                 135                 140                 
Met Val Glu Ser Phe Lys Phe Ile Ser Gly Ile Leu Ala Ala Leu Ser
145                 150                 155                 160 
Ala Met Ile Ser Leu Glu Ile Pro Gln Val Asn Ile Met Thr Lys Met
                165                 170                 175     
Asp Leu Leu Ser Lys Lys Ala Lys Lys Glu Ile Glu Lys Phe Leu Asp
            180                 185                 190         
Pro Asp Met Tyr Ser Leu Leu Glu Asp Ser Thr Ser Asp Leu Arg Ser
        195                 200                 205             
Lys Lys Phe Lys Lys Leu Thr Lys Ala Ile Cys Gly Leu Ile Asp Asp
    210                 215                 220                 
Tyr Ser Met Val Arg Phe Leu Pro Tyr Asp Gln Ser Asp Glu Glu Ser
225                 230                 235                 240 
Met Asn Ile Val Leu Gln His Ile Asp Phe Ala Ile Gln Tyr Gly Glu
                245                 250                 255     
Asp Leu Glu Phe Lys Glu Pro Lys Glu Arg Glu Asp Glu Ser Ser Ser
            260                 265                 270         
Met Phe Asp Glu Tyr Phe Gln Glu Cys Gln Asp Glu
        275                 280                 


<210> 6872
<211> 514
<212> PRT
<213> Homo sapiens

<400> 6872
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser
 1               5                  10                  15      
Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser
            20                  25                  30          
Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn
        35                  40                  45              
Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu
    50                  55                  60                  
Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro
65                  70                  75                  80  
Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu
                85                  90                  95      
Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn
            100                 105                 110         
Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro
        115                 120                 125             
Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe
    130                 135                 140                 
Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile
145                 150                 155                 160 
Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly
                165                 170                 175     
Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser
            180                 185                 190         
Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp
        195                 200                 205             
Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys
    210                 215                 220                 
Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg
225                 230                 235                 240 
Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe
                245                 250                 255     
Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr
            260                 265                 270         
Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile
        275                 280                 285             
Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met
    290                 295                 300                 
Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys
305                 310                 315                 320 
Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln
                325                 330                 335     
Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met
            340                 345                 350         
Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val
        355                 360                 365             
Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu
    370                 375                 380                 
Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu
385                 390                 395                 400 
His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr
                405                 410                 415     
Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp
            420                 425                 430         
Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr
        435                 440                 445             
Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg
    450                 455                 460                 
Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro
465                 470                 475                 480 
Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly
                485                 490                 495     
Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala
            500                 505                 510         
Val Leu
        


<210> 6873
<211> 543
<212> PRT
<213> Homo sapiens

<400> 6873
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser
 1               5                  10                  15      
Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser
            20                  25                  30          
Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn
        35                  40                  45              
Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu
    50                  55                  60                  
Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro
65                  70                  75                  80  
Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu
                85                  90                  95      
Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn
            100                 105                 110         
Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro
        115                 120                 125             
Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe
    130                 135                 140                 
Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile
145                 150                 155                 160 
Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly
                165                 170                 175     
Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser
            180                 185                 190         
Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp
        195                 200                 205             
Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys
    210                 215                 220                 
Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg
225                 230                 235                 240 
Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe
                245                 250                 255     
Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr
            260                 265                 270         
Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile
        275                 280                 285             
Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met
    290                 295                 300                 
Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys
305                 310                 315                 320 
Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln
                325                 330                 335     
Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn
            340                 345                 350         
Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp
        355                 360                 365             
Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu
    370                 375                 380                 
Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly
385                 390                 395                 400 
Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile
                405                 410                 415     
Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr
            420                 425                 430         
Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile
        435                 440                 445             
Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys
    450                 455                 460                 
Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala
465                 470                 475                 480 
Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln
                485                 490                 495     
Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu
            500                 505                 510         
Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu
        515                 520                 525             
Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala Val Leu
    530                 535                 540             


<210> 6874
<211> 873
<212> PRT
<213> Homo sapiens

<400> 6874
Met Ala Ser Arg Arg Lys Ser Thr Thr Pro Cys Met Val Leu Ala Ser
 1               5                  10                  15      
Glu Gln Asp Pro Asp Leu Glu Leu Ile Ser Asp Leu Asp Glu Gly Pro
            20                  25                  30          
Pro Val Leu Thr Pro Val Glu Asn Thr Arg Ala Glu Ser Ile Ser Ser
        35                  40                  45              
Asp Glu Glu Val His Glu Ser Val Asp Ser Asp Asn Gln Gln Asn Lys
    50                  55                  60                  
Lys Val Glu Gly Gly Tyr Glu Cys Lys Tyr Cys Thr Phe Gln Thr Pro
65                  70                  75                  80  
Asp Leu Asn Met Phe Thr Phe His Val Asp Ser Glu His Pro Asn Val
                85                  90                  95      
Val Leu Asn Ser Ser Tyr Val Cys Val Glu Cys Asn Phe Leu Thr Lys
            100                 105                 110         
Arg Tyr Asp Ala Leu Ser Glu His Asn Leu Lys Tyr His Pro Gly Glu
        115                 120                 125             
Glu Asn Phe Lys Leu Thr Met Val Lys Arg Asn Asn Gln Thr Ile Phe
    130                 135                 140                 
Glu Gln Thr Ile Asn Asp Leu Thr Phe Asp Gly Ser Phe Val Lys Glu
145                 150                 155                 160 
Glu Asn Ala Glu Gln Ala Glu Ser Thr Glu Val Ser Ser Ser Gly Ile
                165                 170                 175     
Ser Ile Ser Lys Thr Pro Ile Met Lys Met Met Lys Asn Lys Val Glu
            180                 185                 190         
Asn Lys Arg Ile Ala Val His His Asn Ser Val Glu Asp Val Pro Glu
        195                 200                 205             
Glu Lys Glu Asn Glu Ile Lys Pro Asp Arg Glu Glu Ile Val Glu Asn
    210                 215                 220                 
Pro Ser Ser Ser Ala Ser Glu Ser Asn Thr Ser Thr Ser Ile Val Asn
225                 230                 235                 240 
Arg Ile His Pro Ser Thr Ala Ser Thr Val Val Thr Pro Ala Ala Val
                245                 250                 255     
Leu Pro Gly Leu Ala Gln Met Ile Thr Ala Val Ser Ala Gln Gln Asn
            260                 265                 270         
Ser Asn Leu Ile Pro Lys Val Leu Ile Pro Val Asn Ser Ile Pro Thr
        275                 280                 285             
Tyr Asn Ala Ala Leu Asp Asn Asn Pro Leu Leu Leu Asn Thr Tyr Asn
    290                 295                 300                 
Lys Phe Pro Tyr Pro Thr Met Ser Glu Ile Thr Val Leu Ser Ala Gln
305                 310                 315                 320 
Ala Lys Tyr Thr Glu Glu Gln Ile Lys Ile Trp Phe Ser Ala Gln Arg
                325                 330                 335     
Leu Lys His Gly Val Ser Trp Thr Pro Glu Glu Val Glu Glu Ala Arg
            340                 345                 350         
Arg Lys Gln Phe Asn Gly Thr Val His Thr Val Pro Gln Thr Ile Thr
        355                 360                 365             
Val Ile Pro Thr His Ile Ser Thr Gly Ser Asn Gly Leu Pro Ser Ile
    370                 375                 380                 
Leu Gln Thr Cys Gln Ile Val Gly Gln Pro Gly Leu Val Leu Thr Gln
385                 390                 395                 400 
Val Ala Gly Thr Asn Thr Leu Pro Val Thr Ala Pro Ile Ala Leu Thr
                405                 410                 415     
Val Ala Gly Val Pro Ser Gln Asn Asn Ile Gln Lys Ser Gln Val Pro
            420                 425                 430         
Ala Ala Gln Pro Thr Ala Glu Thr Lys Pro Ala Thr Ala Ala Val Pro
        435                 440                 445             
Thr Ser Gln Ser Val Lys His Glu Thr Ala Leu Val Asn Pro Asp Ser
    450                 455                 460                 
Phe Gly Ile Arg Ala Lys Lys Thr Lys Glu Gln Leu Ala Glu Leu Lys
465                 470                 475                 480 
Val Ser Tyr Leu Lys Asn Gln Phe Pro His Asp Ser Glu Ile Ile Arg
                485                 490                 495     
Leu Met Lys Ile Thr Gly Leu Thr Lys Gly Glu Ile Lys Lys Trp Phe
            500                 505                 510         
Ser Asp Thr Arg Tyr Asn Gln Arg Asn Ser Lys Ser Asn Gln Cys Leu
        515                 520                 525             
His Leu Asn Asn Asp Ser Ser Thr Thr Ile Ile Ile Asp Ser Ser Asp
    530                 535                 540                 
Glu Thr Thr Glu Ser Pro Thr Val Gly Thr Ala Gln Pro Lys Gln Ser
545                 550                 555                 560 
Trp Asn Pro Phe Pro Asp Phe Thr Pro Gln Lys Phe Lys Glu Lys Thr
                565                 570                 575     
Ala Glu Gln Leu Arg Val Leu Gln Ala Ser Phe Leu Asn Ser Ser Val
            580                 585                 590         
Leu Thr Asp Glu Glu Leu Asn Arg Leu Arg Ala Gln Thr Lys Leu Thr
        595                 600                 605             
Arg Arg Glu Ile Asp Ala Trp Phe Thr Glu Lys Lys Lys Ser Lys Ala
    610                 615                 620                 
Leu Lys Glu Glu Lys Met Glu Ile Asp Glu Ser Asn Ala Gly Ser Ser
625                 630                 635                 640 
Lys Glu Glu Ala Gly Glu Thr Ser Pro Ala Asp Glu Ser Gly Ala Pro
                645                 650                 655     
Lys Ser Gly Ser Thr Gly Lys Ile Cys Lys Lys Thr Pro Glu Gln Leu
            660                 665                 670         
His Met Leu Lys Ser Ala Phe Val Arg Thr Gln Trp Pro Ser Pro Glu
        675                 680                 685             
Glu Tyr Asp Lys Leu Ala Lys Glu Ser Gly Leu Ala Arg Thr Asp Ile
    690                 695                 700                 
Val Ser Trp Phe Gly Asp Thr Arg Tyr Ala Trp Lys Asn Gly Asn Leu
705                 710                 715                 720 
Lys Trp Tyr Tyr Tyr Tyr Gln Ser Ala Asn Ser Ser Ser Met Asn Gly
                725                 730                 735     
Leu Ser Ser Leu Arg Lys Arg Gly Arg Gly Arg Pro Lys Gly Arg Gly
            740                 745                 750         
Arg Gly Arg Pro Arg Gly Arg Pro Arg Gly Ser Lys Arg Ile Asn Asn
        755                 760                 765             
Trp Asp Arg Gly Pro Ser Leu Ile Lys Phe Lys Thr Gly Thr Ala Ile
    770                 775                 780                 
Leu Lys Asp Tyr Tyr Leu Lys Arg Lys Phe Leu Asn Glu Gln Asp Leu
785                 790                 795                 800 
Asp Glu Leu Val Asn Lys Ser His Met Gly Tyr Glu Gln Val Arg Glu
                805                 810                 815     
Trp Phe Ala Glu Arg Gln Arg Arg Ser Glu Leu Gly Ile Glu Leu Phe
            820                 825                 830         
Glu Glu Asn Glu Glu Glu Asp Glu Val Ile Asp Asp Gln Glu Glu Asp
        835                 840                 845             
Glu Glu Glu Thr Asp Asp Ser Asp Thr Trp Glu Pro Pro Arg His Val
    850                 855                 860                 
Lys Arg Lys Leu Ser Lys Ser Asp Asp
865                 870             


<210> 6875
<211> 3122
<212> PRT
<213> Homo sapiens

<400> 6875
Met Ser Thr Asp Gly Ser Ala Glu Pro Gln Ser Pro Pro Pro Val Pro
 1               5                  10                  15      
Pro Ser Ile Arg Glu Asp Gly Arg Lys Ala Asn Val Ser Gly Met Ala
            20                  25                  30          
Gly Gln Ser Leu Thr Leu Glu Cys Asp Ala Asn Gly Phe Pro Val Pro
        35                  40                  45              
Glu Ile Val Trp Leu Lys Asp Ala Gln Leu Ile Pro Lys Val Gly Gly
    50                  55                  60                  
His Arg Leu Leu Asp Glu Gly Gln Ser Leu His Phe Pro Arg Ile Gln
65                  70                  75                  80  
Glu Gly Asp Ser Gly Leu Tyr Ser Cys Arg Ala Glu Asn Gln Ala Gly
                85                  90                  95      
Thr Ala Gln Arg Asp Phe His Leu Leu Val Leu Thr Pro Pro Ser Val
            100                 105                 110         
Leu Gly Ala Gly Ala Ala Gln Glu Val Leu Gly Leu Ala Gly Ala Asp
        115                 120                 125             
Val Glu Leu Gln Cys Trp Thr Ser Gly Val Pro Thr Pro Gln Val Glu
    130                 135                 140                 
Trp Thr Lys Asp Arg Gln Pro Val Leu Pro Gly Gly Pro His Leu Gln
145                 150                 155                 160 
Val Gln Glu Asp Gly Gln Val Leu Arg Ile Thr Gly Ser His Val Gly
                165                 170                 175     
Asp Glu Gly Arg Tyr Gln Cys Val Ala Phe Ser Pro Ala Gly Gln Gln
            180                 185                 190         
Ala Arg Asp Phe Gln Leu Arg Val His Ala Pro Pro Thr Ile Trp Gly
        195                 200                 205             
Ser Asn Glu Thr Gly Glu Val Ala Val Met Glu Asp His Leu Val Gln
    210                 215                 220                 
Leu Leu Cys Glu Ala Arg Gly Val Pro Thr Pro Asn Ile Thr Trp Phe
225                 230                 235                 240 
Lys Asp Gly Ala Leu Leu Pro Thr Ser Thr Lys Val Val Tyr Thr Arg
                245                 250                 255     
Gly Gly Arg Gln Leu Gln Leu Gly Arg Ala Gln Ser Ser Asp Ala Gly
            260                 265                 270         
Val Tyr Thr Cys Lys Ala Ser Asn Ala Val Gly Ala Ala Glu Lys Ala
        275                 280                 285             
Thr Arg Leu Asp Val Tyr Val Pro Pro Thr Ile Glu Gly Ala Gly Gly
    290                 295                 300                 
Arg Pro Tyr Val Val Lys Ala Val Ala Gly Arg Pro Val Ala Leu Glu
305                 310                 315                 320 
Cys Val Ala Arg Gly His Pro Ser Pro Thr Leu Ser Trp His His Glu
                325                 330                 335     
Gly Leu Pro Val Ala Glu Ser Asn Glu Ser Arg Leu Glu Thr Asp Gly
            340                 345                 350         
Ser Val Leu Arg Leu Glu Ser Pro Gly Glu Ala Ser Ser Gly Leu Tyr
        355                 360                 365             
Ser Cys Val Ala Ser Ser Pro Ala Gly Glu Ala Val Leu Gln Tyr Ser
    370                 375                 380                 
Val Glu Val Gln Val Pro Pro Gln Leu Leu Val Ala Glu Gly Leu Gly
385                 390                 395                 400 
Gln Val Thr Thr Ile Val Gly Gln Pro Leu Glu Leu Pro Cys Gln Ala
                405                 410                 415     
Ser Gly Ser Pro Val Pro Thr Ile Gln Trp Leu Gln Asn Gly Arg Pro
            420                 425                 430         
Ala Glu Glu Leu Ala Gly Val Gln Val Ala Ser Gln Gly Thr Thr Leu
        435                 440                 445             
His Ile Asp His Val Glu Leu Asp His Ser Gly Leu Phe Ala Cys Gln
    450                 455                 460                 
Ala Thr Asn Glu Ala Gly Thr Ala Gly Ala Glu Val Glu Val Ser Val
465                 470                 475                 480 
His Glu Phe Pro Ser Val Ser Ile Ile Gly Gly Glu Asn Ile Thr Ala
                485                 490                 495     
Pro Phe Leu Gln Pro Val Thr Leu Gln Cys Ile Gly Asp Gly Val Pro
            500                 505                 510         
Thr Pro Ser Leu Arg Trp Trp Lys Asp Gly Val Ala Leu Ala Ala Phe
        515                 520                 525             
Gly Gly Asn Leu Gln Ile Glu Lys Val Asp Leu Arg Asp Glu Gly Ile
    530                 535                 540                 
Tyr Thr Cys Ala Ala Thr Asn Leu Ala Gly Glu Ser Lys Arg Glu Val
545                 550                 555                 560 
Ala Leu Lys Val Leu Val Pro Pro Asn Ile Glu Pro Gly Pro Val Asn
                565                 570                 575     
Lys Ala Val Leu Glu Asn Ala Ser Val Thr Leu Glu Cys Leu Ala Ser
            580                 585                 590         
Gly Val Pro Pro Pro Asp Val Ser Trp Phe Lys Gly His Gln Pro Val
        595                 600                 605             
Ser Ser Trp Met Gly Val Thr Val Ser Val Asp Gly Arg Val Leu Arg
    610                 615                 620                 
Ile Glu Gln Ala Gln Leu Ser Asp Ala Gly Ser Tyr Arg Cys Val Ala
625                 630                 635                 640 
Ser Asn Val Ala Gly Ser Thr Glu Leu Arg Tyr Gly Leu Arg Val Asn
                645                 650                 655     
Val Pro Pro Arg Ile Thr Leu Pro Pro Ser Leu Pro Gly Pro Val Leu
            660                 665                 670         
Val Asn Thr Pro Val Arg Leu Thr Cys Asn Ala Thr Gly Ala Pro Ser
        675                 680                 685             
Pro Thr Leu Met Trp Leu Lys Asp Gly Asn Pro Val Ser Pro Ala Gly
    690                 695                 700                 
Thr Pro Gly Leu Gln Val Phe Pro Gly Gly Arg Val Leu Thr Leu Ala
705                 710                 715                 720 
Ser Ala Arg Ala Ser Asp Ser Gly Arg Tyr Ser Cys Val Ala Val Ser
                725                 730                 735     
Ala Val Gly Glu Asp Arg Gln Asp Val Val Leu Gln Val His Met Pro
            740                 745                 750         
Pro Ser Ile Leu Gly Glu Glu Leu Asn Val Ser Val Val Ala Asn Glu
        755                 760                 765             
Ser Val Ala Leu Glu Cys Gln Ser His Ala Met Pro Pro Pro Val Leu
    770                 775                 780                 
Ser Trp Trp Lys Asp Gly Arg Pro Leu Glu Pro Arg Pro Gly Val His
785                 790                 795                 800 
Leu Ser Ala Asp Lys Ala Leu Leu Gln Val Asp Arg Ala Asp Val Trp
                805                 810                 815     
Asp Ala Gly His Tyr Thr Cys Glu Ala Leu Asn Gln Ala Gly His Ser
            820                 825                 830         
Glu Lys His Tyr Asn Leu Asn Val Trp Gly Gln Pro Leu Pro Gly Glu
        835                 840                 845             
Gly Ala Gly Leu Gln His Val Ser Ala Val Gly Arg Leu Leu Tyr Leu
    850                 855                 860                 
Gly Gln Ala Gln Leu Ala Gln Glu Gly Thr Tyr Thr Cys Glu Cys Ser
865                 870                 875                 880 
Asn Val Val Gly Asn Ser Ser Gln Asp Leu Gln Leu Glu Val His Val
                885                 890                 895     
Pro Pro Gln Ile Ala Gly Pro Arg Glu Pro Pro Thr Gln Val Ser Val
            900                 905                 910         
Val Gln Asp Gly Val Ala Thr Leu Glu Cys Asn Ala Thr Gly Lys Pro
        915                 920                 925             
Pro Pro Thr Val Thr Trp Glu Arg Asp Gly Gln Pro Val Gly Ala Glu
    930                 935                 940                 
Leu Gly Leu Gln Leu Gln Asn Gln Gly Gln Ser Leu His Val Glu Arg
945                 950                 955                 960 
Ala Gln Ala Ala His Thr Gly Arg Tyr Ser Cys Val Ala Glu Asn Leu
                965                 970                 975     
Ala Gly Arg Ala Glu Arg Lys Phe Glu Leu Ser Val Leu Val Pro Pro
            980                 985                 990         
Glu Leu Ile Gly Asp Leu Asp Pro Leu Thr Asn Ile Thr Ala Ala Leu
        995                 1000                1005            
His Ser Pro Leu Thr Leu Leu Cys Glu Ala Met Gly Ile Pro Pro Pro
    1010                1015                1020                
Ala Ile Arg Trp Phe Arg Gly Glu Glu Pro Val Ser Pro Gly Glu Asp
1025                1030                1035                1040
Thr Tyr Leu Leu Ala Gly Gly Trp Met Leu Lys Met Thr Gln Thr Gln
                1045                1050                1055    
Glu Gln Asp Ser Gly Leu Tyr Ser Cys Leu Ala Ser Asn Glu Ala Gly
            1060                1065                1070        
Glu Ala Arg Arg Asn Phe Ser Val Glu Val Leu Val Pro Pro Ser Ile
        1075                1080                1085            
Glu Asn Glu Asp Leu Glu Glu Val Ile Lys Val Leu Asp Gly Gln Thr
    1090                1095                1100                
Ala His Leu Met Cys Asn Val Thr Gly His Pro Gln Pro Lys Leu Thr
1105                1110                1115                1120
Trp Phe Lys Asp Gly Arg Pro Leu Ala Arg Gly Asp Ala His His Ile
                1125                1130                1135    
Ser Pro Asp Gly Val Leu Leu Gln Val Leu Gln Ala Asn Leu Ser Ser
            1140                1145                1150        
Ala Gly His Tyr Ser Cys Ile Ala Ala Asn Ala Val Gly Glu Lys Thr
        1155                1160                1165            
Lys His Phe Gln Leu Ser Val Leu Leu Ala Pro Thr Ile Leu Gly Gly
    1170                1175                1180                
Ala Glu Asp Ser Ala Asp Glu Glu Val Thr Val Thr Val Asn Asn Pro
1185                1190                1195                1200
Ile Ser Leu Ile Cys Glu Ala Leu Ala Phe Pro Ser Pro Asn Ile Thr
                1205                1210                1215    
Trp Met Lys Asp Gly Ala Pro Phe Glu Ala Ser Arg Asn Ile Gln Leu
            1220                1225                1230        
Leu Pro Gly Thr His Gly Leu Gln Ile Leu Asn Ala Gln Lys Glu Asp
        1235                1240                1245            
Ala Gly Gln Tyr Thr Cys Val Val Thr Asn Glu Leu Gly Glu Ala Val
    1250                1255                1260                
Lys Asn Tyr His Val Glu Val Leu Ile Pro Pro Ser Ile Ser Lys Asp
1265                1270                1275                1280
Asp Pro Leu Ala Glu Val Gly Val Lys Glu Val Lys Thr Lys Val Asn
                1285                1290                1295    
Ser Thr Leu Thr Leu Glu Cys Glu Ser Trp Ala Val Pro Pro Pro Thr
            1300                1305                1310        
Ile Arg Trp Tyr Lys Asp Gly Gln Pro Val Thr Pro Ser Ser Arg Leu
        1315                1320                1325            
Gln Val Leu Gly Glu Gly Arg Leu Leu Gln Ile Gln Pro Thr Gln Val
    1330                1335                1340                
Ser Asp Ser Gly Arg Tyr Leu Cys Val Ala Thr Asn Val Ala Gly Glu
1345                1350                1355                1360
Asp Asp Gln Asp Phe Asn Val Leu Ile Gln Val Pro Pro Met Phe Gln
                1365                1370                1375    
Lys Val Gly Asp Phe Ser Ala Ala Phe Glu Ile Leu Ser Arg Glu Glu
            1380                1385                1390        
Glu Ala Arg Gly Gly Val Thr Glu Tyr Arg Glu Ile Val Glu Asn Asn
        1395                1400                1405            
Pro Ala Tyr Leu Tyr Cys Asp Thr Asn Ala Ile Pro Pro Pro Asp Leu
    1410                1415                1420                
Thr Trp Tyr Arg Glu Asp Gln Pro Leu Ser Ala Gly Asp Glu Val Ser
1425                1430                1435                1440
Val Leu Gln Gly Gly Arg Val Leu Gln Ile Pro Leu Val Arg Ala Glu
                1445                1450                1455    
Asn Ala Gly Arg Tyr Ser Cys Lys Ala Ser Asn Glu Val Gly Glu Asp
            1460                1465                1470        
Trp Leu His Tyr Glu Leu Leu Val Leu Lys Glu Leu Val Glu Glu Val
        1475                1480                1485            
Thr Val Asn Ala Ser Ser Thr Val Ser Leu Gln Cys Pro Ala Leu Gly
    1490                1495                1500                
Asn Pro Val Pro Thr Ile Ser Trp Leu Gln Asn Gly Leu Pro Phe Ser
1505                1510                1515                1520
Pro Ser Pro Arg Leu Gln Val Leu Glu Asp Gly Gln Val Leu Gln Val
                1525                1530                1535    
Ser Thr Ala Glu Val Ala Asp Ala Ala Ser Tyr Met Cys Val Ala Glu
            1540                1545                1550        
Asn Gln Ala Gly Ser Ala Glu Lys Leu Phe Thr Leu Arg Val Gln Gly
        1555                1560                1565            
Leu Asp Leu Glu Gln Val Thr Ala Ile Leu Asn Ser Ser Val Ser Leu
    1570                1575                1580                
Pro Cys Asp Val His Ala His Pro Asn Pro Glu Val Thr Trp Tyr Lys
1585                1590                1595                1600
Asp Ser Gln Ala Leu Ser Leu Gly Glu Glu Val Phe Leu Leu Pro Gly
                1605                1610                1615    
Thr His Thr Leu Gln Leu Gly Arg Ala Arg Leu Ser Asp Ser Gly Met
            1620                1625                1630        
Tyr Thr Cys Glu Ala Leu Asn Ala Ala Gly Arg Asp Gln Lys Leu Val
        1635                1640                1645            
Gln Leu Ser Val Leu Val Pro Pro Ala Phe Arg Gln Ala Pro Arg Gly
    1650                1655                1660                
Pro Gln Asp Ala Val Leu Val Arg Val Gly Asp Lys Ala Val Leu Ser
1665                1670                1675                1680
Cys Glu Thr Asp Ala Leu Pro Glu Pro Thr Val Thr Trp Tyr Lys Asp
                1685                1690                1695    
Gly Gln Pro Leu Val Leu Ala Gln Arg Thr Gln Ala Leu Arg Gly Gly
            1700                1705                1710        
Gln Arg Leu Glu Ile Gln Glu Ala Gln Val Ser Asp Lys Gly Leu Tyr
        1715                1720                1725            
Ser Cys Lys Val Ser Asn Val Ala Gly Glu Ala Val Arg Thr Phe Thr
    1730                1735                1740                
Leu Thr Val Gln Val Pro Pro Thr Phe Glu Asn Pro Lys Thr Glu Thr
1745                1750                1755                1760
Val Ser Gln Val Ala Gly Ser Pro Leu Val Leu Thr Cys Asp Val Ser
                1765                1770                1775    
Gly Val Pro Ala Pro Thr Val Thr Trp Leu Lys Asp Arg Met Pro Val
            1780                1785                1790        
Glu Ser Ser Ala Val His Gly Val Val Ser Arg Gly Gly Arg Leu Gln
        1795                1800                1805            
Leu Ser Arg Leu Gln Pro Ala Gln Ala Gly Thr Tyr Thr Cys Val Ala
    1810                1815                1820                
Glu Asn Thr Gln Ala Glu Ala Arg Lys Asp Phe Val Val Ala Val Leu
1825                1830                1835                1840
Val Ala Pro Arg Ile Arg Ser Ser Gly Val Ala Arg Glu His His Val
                1845                1850                1855    
Leu Glu Gly Gln Glu Val Arg Leu Asp Cys Glu Ala Asp Gly Gln Pro
            1860                1865                1870        
Pro Pro Asp Val Ala Trp Leu Lys Asp Gly Ser Pro Leu Gly Gln Asp
        1875                1880                1885            
Met Gly Pro His Leu Arg Phe Tyr Leu Asp Gly Gly Ser Leu Val Leu
    1890                1895                1900                
Lys Gly Leu Arg Ala Ser Asp Ala Gly Ala Tyr Thr Cys Val Ala His
1905                1910                1915                1920
Asn Pro Ala Gly Glu Asp Ala Arg Leu His Thr Val Asn Val Leu Glu
                1925                1930                1935    
Asp Asn Ser Ala Ser Pro Gly Tyr Ser Gly Asp Ser Gly Val Pro Pro
            1940                1945                1950        
Thr Ile Lys Gln Gly Ala Asp Gly Ser Gly Thr Leu Val Ser Arg Pro
        1955                1960                1965            
Gly Glu Leu Val Thr Met Val Cys Pro Val Arg Gly Ser Pro Pro Ile
    1970                1975                1980                
His Val Ser Trp Leu Lys Asp Gly Leu Pro Leu Pro Leu Ser Gln Arg
1985                1990                1995                2000
Thr Leu Leu His Gly Ser Gly His Thr Leu Arg Ile Ser Lys Val Gln
                2005                2010                2015    
Leu Ala Asp Ala Gly Ile Phe Thr Cys Val Ala Ala Ser Pro Ala Gly
            2020                2025                2030        
Val Ala Asp Arg Asn Phe Thr Leu Gln Val Gln Val Pro Pro Val Leu
        2035                2040                2045            
Glu Pro Val Glu Phe Gln Asn Asp Val Val Val Val Arg Gly Ser Leu
    2050                2055                2060                
Val Glu Leu Pro Cys Glu Ala Arg Gly Val Pro Leu Pro Leu Val Ser
2065                2070                2075                2080
Trp Met Lys Asp Gly Glu Pro Leu Leu Ser Gln Ser Leu Glu Gln Gly
                2085                2090                2095    
Pro Ser Leu Gln Leu Glu Ala Val Gly Ala Gly Asp Ser Gly Thr Tyr
            2100                2105                2110        
Ser Cys Val Ala Val Ser Glu Ala Gly Glu Ala Arg Arg His Phe Gln
        2115                2120                2125            
Leu Thr Val Met Glu Pro Pro His Ile Glu Asp Ser Gly Gln Pro Thr
    2130                2135                2140                
Glu Leu Ser Leu Thr Pro Gly Ala Pro Met Glu Leu Leu Cys Asp Ala
2145                2150                2155                2160
Gln Gly Thr Pro Gln Pro Asn Ile Thr Trp His Lys Asp Gly Gln Ala
                2165                2170                2175    
Leu Thr Arg Leu Glu Asn Asn Ser Arg Ala Thr Arg Val Leu Arg Val
            2180                2185                2190        
Glu Asn Val Gln Val Arg Asp Ala Gly Leu Tyr Thr Cys Leu Ala Glu
        2195                2200                2205            
Ser Pro Ala Gly Ala Ile Glu Lys Ser Phe Arg Val Arg Val Gln Ala
    2210                2215                2220                
Pro Pro Asn Ile Val Gly Pro Arg Gly Pro Arg Phe Val Val Gly Leu
2225                2230                2235                2240
Ala Pro Gly Gln Leu Val Leu Glu Cys Ser Val Glu Ala Glu Pro Ala
                2245                2250                2255    
Pro Lys Ile Thr Trp His Arg Asp Gly Ile Val Leu Gln Glu Asp Ala
            2260                2265                2270        
His Thr Gln Phe Pro Glu Arg Gly Arg Phe Leu Gln Leu Gln Ala Leu
        2275                2280                2285            
Ser Thr Ala Asp Ser Gly Asp Tyr Ser Cys Thr Ala Arg Asn Ala Ala
    2290                2295                2300                
Gly Ser Thr Ser Val Ala Phe Arg Val Glu Ile His Thr Val Pro Thr
2305                2310                2315                2320
Ile Arg Ser Gly Pro Pro Ala Val Asn Val Ser Val Asn Gln Thr Ala
                2325                2330                2335    
Leu Leu Pro Cys Gln Ala Asp Gly Val Pro Ala Pro Leu Val Ser Trp
            2340                2345                2350        
Arg Lys Asp Arg Val Pro Leu Asp Pro Arg Ser Pro Arg Phe Glu Ile
        2355                2360                2365            
Leu Pro Glu Gly Ser Leu Arg Ile Gln Pro Val Leu Ala Gln Asp Ala
    2370                2375                2380                
Gly His Tyr Leu Cys Leu Ala Ser Asn Ser Ala Gly Ser Asp Arg Gln
2385                2390                2395                2400
Gly Arg Asp Leu Arg Val Leu Glu Pro Pro Ala Ile Ala Pro Ser Pro
                2405                2410                2415    
Ser Asn Leu Thr Leu Thr Ala His Thr Pro Ala Leu Leu Pro Cys Glu
            2420                2425                2430        
Ala Ser Gly Ser Pro Lys Pro Leu Val Val Trp Trp Lys Asp Gly Gln
        2435                2440                2445            
Lys Leu Asp Phe Arg Leu Gln Gln Gly Ala Tyr Arg Leu Leu Pro Ser
    2450                2455                2460                
Asn Ala Leu Leu Leu Thr Ala Pro Gly Pro Gln Asp Ser Ala Gln Phe
2465                2470                2475                2480
Glu Cys Val Val Ser Asn Glu Val Gly Glu Ala His Arg Leu Tyr Gln
                2485                2490                2495    
Val Thr Val His Ala Leu Pro Pro Gly Pro Val Ala Val Ser Ala Leu
            2500                2505                2510        
Cys Pro Pro Ala Gly Pro Gln Ala Leu Ser Trp Val Leu Val Pro Pro
        2515                2520                2525            
Thr Ile Ala Asp Asp Gln Thr Asp Phe Thr Val Thr Met Met Ala Pro
    2530                2535                2540                
Val Val Leu Thr Cys His Ser Thr Gly Ile Pro Ala Pro Thr Val Ser
2545                2550                2555                2560
Trp Ser Lys Ala Gly Ala Gln Leu Gly Ala Arg Gly Ser Gly Tyr Arg
                2565                2570                2575    
Val Ser Pro Ser Gly Ala Leu Glu Ile Gly Gln Ala Leu Pro Ile His
            2580                2585                2590        
Ala Gly Arg Tyr Thr Cys Ser Ala Arg Asn Ser Ala Gly Val Ala His
        2595                2600                2605            
Lys His Val Phe Leu Thr Val Gln Ala Ser Pro Val Val Lys Pro Leu
    2610                2615                2620                
Pro Ser Val Val Arg Ala Val Ala Glu Glu Glu Val Leu Leu Pro Cys
2625                2630                2635                2640
Glu Ala Ser Gly Ile Pro Arg Pro Thr Ile Thr Trp Gln Lys Glu Gly
                2645                2650                2655    
Leu Asn Val Ala Thr Gly Val Ser Thr Gln Val Leu Pro Gly Gly Gln
            2660                2665                2670        
Leu Arg Ile Ala His Ala Ser Pro Glu Asp Ala Gly Asn Tyr Leu Cys
        2675                2680                2685            
Ile Ala Lys Asn Ser Ala Gly Ser Ala Met Gly Lys Thr Arg Leu Val
    2690                2695                2700                
Val Gln Val Pro Pro Val Ile Glu Asn Gly Leu Pro Asp Leu Ser Thr
2705                2710                2715                2720
Thr Glu Gly Ser His Ala Phe Leu Pro Cys Lys Ala Arg Gly Ser Pro
                2725                2730                2735    
Glu Pro Asn Ile Thr Trp Asp Lys Asp Gly Gln Pro Val Ser Gly Ala
            2740                2745                2750        
Glu Gly Lys Phe Thr Ile Gln Pro Ser Gly Glu Leu Leu Val Lys Asn
        2755                2760                2765            
Leu Glu Gly Gln Asp Ala Gly Thr Tyr Thr Cys Thr Ala Glu Asn Ala
    2770                2775                2780                
Val Gly Arg Ala Arg Arg Arg Val His Leu Thr Ile Leu Val Leu Pro
2785                2790                2795                2800
Val Phe Thr Thr Leu Pro Gly Asp Arg Ser Leu Arg Leu Gly Asp Arg
                2805                2810                2815    
Leu Trp Leu Arg Cys Ala Ala Arg Gly Ser Pro Thr Pro Arg Ile Gly
            2820                2825                2830        
Trp Thr Val Asn Asp Arg Pro Val Thr Glu Gly Val Ser Glu Gln Asp
        2835                2840                2845            
Gly Gly Ser Thr Leu Gln Arg Ala Ala Val Ser Arg Glu Asp Ser Gly
    2850                2855                2860                
Thr Tyr Val Cys Trp Ala Glu Asn Arg Val Gly Arg Thr Gln Ala Val
2865                2870                2875                2880
Ser Phe Val His Val Lys Glu Ala Pro Val Leu Gln Gly Glu Ala Phe
                2885                2890                2895    
Ser Tyr Leu Val Glu Pro Val Gly Gly Ser Ile Gln Leu Asp Cys Val
            2900                2905                2910        
Val Arg Gly Asp Pro Val Pro Asp Ile His Trp Ile Lys Asp Gly Leu
        2915                2920                2925            
Pro Leu Arg Gly Ser His Leu Arg His Gln Leu Gln Asn Gly Ser Leu
    2930                2935                2940                
Thr Ile Arg Arg Thr Glu Ala Arg Arg Gly Leu Ala Pro Trp Arg Asp
2945                2950                2955                2960
Asp Ala Gly Arg Tyr Gln Cys Leu Ala Glu Asn Glu Met Gly Val Ala
                2965                2970                2975    
Lys Lys Val Val Ile Leu Val Leu Gln Ser Ala Pro Val Phe Gln Val
            2980                2985                2990        
Glu Pro Gln Asp Met Thr Val Arg Ser Gly Asp Asp Val Ala Leu Arg
        2995                3000                3005            
Cys Gln Ala Thr Gly Glu Pro Thr Pro Thr Ile Glu Trp Leu Gln Ala
    3010                3015                3020                
Gly Gln Pro Leu Arg Ala Ser Arg Arg Leu Arg Thr Leu Pro Asp Gly
3025                3030                3035                3040
Ser Leu Trp Leu Glu Asn Val Glu Thr Gly Asp Ala Gly Thr Tyr Asp
                3045                3050                3055    
Cys Val Ala His Asn Leu Leu Gly Ser Ala Thr Ala Arg Ala Phe Leu
            3060                3065                3070        
Val Val Arg Gly Met Gly His Pro Cys Leu Asp Leu Arg Gly Gln Arg
        3075                3080                3085            
Gln Asp Leu Leu Pro Met Gly Ile Val Trp Cys Leu Trp Glu Thr Cys
    3090                3095                3100                
Pro Leu Pro Cys Gln Leu Pro Thr Ser Ser Leu Cys Phe Ile Thr Ser
3105                3110                3115                3120
Pro Glu
        


<210> 6876
<211> 1188
<212> PRT
<213> Homo sapiens

<400> 6876
Met Glu Pro Asn Ser Leu Gln Trp Val Gly Ser Pro Cys Gly Leu His
 1               5                  10                  15      
Gly Pro Tyr Ile Phe Tyr Lys Ala Phe Gln Phe His Leu Glu Gly Lys
            20                  25                  30          
Pro Arg Ile Leu Ser Leu Gly Asp Phe Phe Phe Val Arg Cys Thr Pro
        35                  40                  45              
Lys Asp Pro Ile Cys Ile Ala Glu Leu Gln Leu Leu Trp Glu Glu Arg
    50                  55                  60                  
Thr Ser Arg Gln Leu Leu Ser Ser Ser Lys Leu Tyr Phe Leu Pro Glu
65                  70                  75                  80  
Asp Thr Pro Gln Gly Arg Asn Ser Asp His Gly Glu Asp Glu Val Ile
                85                  90                  95      
Ala Val Ser Glu Lys Val Ile Val Lys Leu Glu Asp Leu Val Lys Trp
            100                 105                 110         
Val His Ser Asp Phe Ser Lys Trp Arg Cys Gly Phe His Ala Gly Pro
        115                 120                 125             
Val Lys Thr Glu Ala Leu Gly Arg Asn Gly Gln Lys Glu Ala Leu Leu
    130                 135                 140                 
Lys Tyr Arg Gln Ser Thr Leu Asn Ser Gly Leu Asn Phe Lys Asp Val
145                 150                 155                 160 
Leu Lys Glu Lys Ala Asp Leu Gly Glu Asp Glu Glu Glu Thr Asn Val
                165                 170                 175     
Ile Val Leu Ser Tyr Pro Gln Tyr Cys Arg Tyr Arg Ser Met Leu Lys
            180                 185                 190         
Arg Ile Gln Asp Lys Pro Ser Ser Ile Leu Thr Asp Gln Phe Ala Leu
        195                 200                 205             
Ala Leu Gly Gly Ile Ala Val Val Ser Arg Asn Pro Gln Ile Leu Tyr
    210                 215                 220                 
Cys Arg Asp Thr Phe Asp His Pro Thr Leu Ile Glu Asn Glu Ser Ile
225                 230                 235                 240 
Cys Asp Glu Phe Ala Pro Asn Leu Lys Gly Arg Pro Arg Lys Lys Lys
                245                 250                 255     
Pro Cys Pro Gln Arg Arg Asp Ser Phe Ser Gly Val Lys Asp Ser Asn
            260                 265                 270         
Asn Asn Ser Asp Gly Lys Ala Val Ala Lys Val Lys Cys Glu Ala Arg
        275                 280                 285             
Ser Ala Leu Thr Lys Pro Lys Asn Asn His Asn Cys Lys Lys Val Ser
    290                 295                 300                 
Asn Glu Glu Lys Pro Lys Val Ala Ile Gly Glu Glu Cys Arg Ala Asp
305                 310                 315                 320 
Glu Gln Ala Phe Leu Val Ala Leu Tyr Lys Tyr Met Lys Glu Arg Lys
                325                 330                 335     
Thr Pro Ile Glu Arg Ile Pro Tyr Leu Gly Phe Lys Gln Ile Asn Leu
            340                 345                 350         
Trp Thr Met Phe Gln Ala Ala Gln Lys Leu Gly Gly Tyr Glu Thr Ile
        355                 360                 365             
Thr Ala Arg Arg Gln Trp Lys His Ile Tyr Asp Glu Leu Gly Gly Asn
    370                 375                 380                 
Pro Gly Ser Thr Ser Ala Ala Thr Cys Thr Arg Arg His Tyr Glu Arg
385                 390                 395                 400 
Leu Ile Leu Pro Tyr Glu Arg Phe Ile Lys Gly Glu Glu Asp Lys Pro
                405                 410                 415     
Leu Pro Pro Ile Lys Pro Arg Lys Gln Glu Asn Ser Ser Gln Glu Asn
            420                 425                 430         
Glu Asn Lys Thr Lys Val Ser Gly Thr Lys Arg Ile Lys His Glu Ile
        435                 440                 445             
Pro Lys Ser Lys Lys Glu Lys Glu Asn Ala Pro Lys Pro Gln Asp Ala
    450                 455                 460                 
Ala Glu Val Ser Ser Glu Gln Glu Lys Glu Gln Glu Thr Leu Ile Ser
465                 470                 475                 480 
Gln Lys Ser Ile Pro Glu Pro Leu Pro Ala Ala Asp Met Lys Lys Lys
                485                 490                 495     
Ile Glu Gly Tyr Gln Glu Phe Ser Ala Lys Pro Leu Ala Ser Arg Val
            500                 505                 510         
Asp Pro Glu Lys Asp Asn Glu Thr Asp Gln Gly Ser Asn Ser Glu Lys
        515                 520                 525             
Val Ala Glu Glu Ala Gly Glu Lys Gly Pro Thr Pro Pro Leu Pro Ser
    530                 535                 540                 
Ala Pro Leu Ala Pro Glu Lys Asp Ser Ala Leu Val Pro Gly Ala Ser
545                 550                 555                 560 
Lys Gln Pro Leu Thr Ser Pro Ser Ala Leu Val Asp Ser Lys Gln Glu
                565                 570                 575     
Ser Lys Leu Cys Cys Phe Thr Glu Ser Pro Glu Ser Glu Pro Gln Glu
            580                 585                 590         
Ala Ser Phe Pro Ser Phe Pro Thr Thr Gln Pro Pro Leu Ala Asn Gln
        595                 600                 605             
Asn Glu Thr Glu Asp Asp Lys Leu Pro Ala Met Ala Asp Tyr Ile Ala
    610                 615                 620                 
Asn Cys Thr Val Lys Val Asp Gln Leu Gly Ser Asp Asp Ile His Asn
625                 630                 635                 640 
Ala Leu Lys Gln Thr Pro Lys Val Leu Val Val Gln Ser Phe Asp Met
                645                 650                 655     
Phe Lys Asp Lys Asp Leu Thr Gly Pro Met Asn Glu Asn His Gly Leu
            660                 665                 670         
Asn Tyr Thr Pro Leu Leu Tyr Ser Arg Gly Asn Pro Gly Ile Met Ser
        675                 680                 685             
Pro Leu Ala Lys Lys Lys Leu Leu Ser Gln Val Ser Gly Ala Ser Leu
    690                 695                 700                 
Ser Ser Ser Tyr Pro Tyr Gly Ser Pro Pro Pro Leu Ile Ser Lys Lys
705                 710                 715                 720 
Lys Leu Ile Ala Arg Asp Asp Leu Cys Ser Ser Leu Ser Gln Thr His
                725                 730                 735     
His Gly Gln Ser Thr Asp His Met Ala Val Ser Arg Pro Ser Val Ile
            740                 745                 750         
Gln His Val Gln Ser Phe Arg Ser Lys Pro Ser Glu Glu Arg Lys Thr
        755                 760                 765             
Ile Asn Asp Ile Phe Lys His Glu Lys Leu Ser Arg Ser Asp Pro His
    770                 775                 780                 
Arg Cys Ser Phe Ser Lys His His Leu Asn Pro Leu Ala Asp Ser Tyr
785                 790                 795                 800 
Val Leu Lys Gln Glu Ile Gln Glu Gly Lys Asp Lys Leu Leu Glu Lys
                805                 810                 815     
Arg Ala Leu Pro His Ser His Met Pro Ser Phe Leu Ala Asp Phe Tyr
            820                 825                 830         
Ser Ser Pro His Leu His Ser Leu Tyr Arg His Thr Glu His His Leu
        835                 840                 845             
His Asn Glu Gln Thr Ser Lys Tyr Pro Ser Arg Asp Met Tyr Arg Glu
    850                 855                 860                 
Ser Glu Asn Ser Ser Phe Pro Ser His Arg His Gln Glu Lys Leu His
865                 870                 875                 880 
Val Asn Tyr Leu Thr Ser Leu His Leu Gln Asp Lys Lys Ser Ala Ala
                885                 890                 895     
Ala Glu Ala Pro Thr Asp Asp Gln Pro Thr Asp Leu Ser Leu Pro Lys
            900                 905                 910         
Asn Pro His Lys Pro Thr Gly Lys Val Leu Gly Leu Ala His Ser Thr
        915                 920                 925             
Thr Gly Pro Gln Glu Ser Lys Gly Ile Ser Gln Phe Gln Val Leu Gly
    930                 935                 940                 
Ser Gln Ser Arg Asp Cys His Pro Lys Ala Cys Arg Val Ser Pro Met
945                 950                 955                 960 
Thr Met Ser Gly Pro Lys Lys Tyr Pro Glu Ser Leu Ser Arg Ser Gly
                965                 970                 975     
Lys Pro His His Val Arg Leu Glu Asn Phe Arg Lys Met Glu Gly Met
            980                 985                 990         
Val His Pro Ile Leu His Arg Lys Met Ser Pro Gln Asn Ile Gly Ala
        995                 1000                1005            
Ala Arg Pro Ile Lys Arg Ser Leu Glu Asp Leu Asp Leu Val Ile Ala
    1010                1015                1020                
Gly Lys Lys Ala Arg Ala Val Ser Pro Leu Asp Pro Ser Lys Glu Val
1025                1030                1035                1040
Ser Gly Lys Glu Lys Ala Ser Glu Gln Glu Ser Glu Gly Ser Lys Ala
                1045                1050                1055    
Ala His Gly Gly His Ser Gly Gly Gly Ser Glu Gly His Lys Leu Pro
            1060                1065                1070        
Leu Ser Ser Pro Ile Phe Pro Gly Leu Tyr Ser Gly Ser Leu Cys Asn
        1075                1080                1085            
Ser Gly Leu Asn Ser Arg Leu Pro Ala Gly Tyr Ser His Ser Leu Gln
    1090                1095                1100                
Tyr Leu Lys Asn Gln Thr Val Leu Ser Pro Leu Met Gln Pro Leu Ala
1105                1110                1115                1120
Phe His Ser Leu Val Met Gln Arg Gly Ile Phe Thr Ser Pro Thr Asn
                1125                1130                1135    
Ser Gln Gln Leu Tyr Arg His Leu Ala Ala Ala Thr Pro Val Gly Ser
            1140                1145                1150        
Ser Tyr Gly Asp Leu Leu His Asn Ser Ile Tyr Pro Leu Ala Ala Ile
        1155                1160                1165            
Asn Pro Gln Ala Ala Phe Pro Ser Ser Gln Leu Ser Ser Val His Pro
    1170                1175                1180                
Ser Thr Lys Leu
1185            


<210> 6877
<211> 246
<212> PRT
<213> Homo sapiens

<400> 6877
Lys Val Ser Asn Glu Glu Lys Pro Lys Val Ala Ile Gly Glu Glu Cys
 1               5                  10                  15      
Arg Ala Asp Glu Gln Ala Phe Leu Val Ala Leu Tyr Lys Tyr Met Lys
            20                  25                  30          
Glu Arg Lys Thr Pro Ile Glu Arg Ile Pro Tyr Leu Gly Phe Lys Gln
        35                  40                  45              
Ile Asn Leu Trp Thr Met Phe Gln Ala Ala Gln Lys Leu Gly Gly Tyr
    50                  55                  60                  
Glu Thr Ile Thr Ala Arg Arg Gln Trp Lys His Ile Tyr Asp Glu Leu
65                  70                  75                  80  
Gly Gly Asn Pro Gly Ser Thr Ser Ala Ala Thr Cys Thr Arg Arg His
                85                  90                  95      
Tyr Glu Arg Leu Ile Leu Pro Tyr Glu Arg Phe Ile Lys Gly Glu Glu
            100                 105                 110         
Asp Lys Pro Leu Pro Pro Ile Lys Pro Arg Lys Gln Glu Asn Ser Ser
        115                 120                 125             
Gln Glu Asn Glu Asn Lys Thr Lys Val Ser Gly Thr Lys Arg Ile Lys
    130                 135                 140                 
His Glu Ile Pro Lys Ser Lys Lys Glu Lys Glu Asn Ala Pro Lys Pro
145                 150                 155                 160 
Gln Asp Ala Ala Glu Val Ser Ser Glu Gln Glu Lys Glu Gln Glu Thr
                165                 170                 175     
Leu Ile Ser Gln Lys Ser Ile Pro Glu Pro Leu Pro Ala Ala Asp Met
            180                 185                 190         
Lys Lys Lys Ile Glu Gly Tyr Gln Glu Phe Ser Ala Lys Pro Leu Ala
        195                 200                 205             
Ser Arg Val Asp Pro Glu Lys Asp Asn Glu Thr Asp Gln Gly Ser Asn
    210                 215                 220                 
Ser Glu Lys Val Ala Glu Glu Ala Gly Glu Lys Gly Pro Thr Pro Pro
225                 230                 235                 240 
Leu Pro Ser Ala Pro Leu
                245     


<210> 6878
<211> 217
<212> PRT
<213> Homo sapiens

<400> 6878
Met Ser Gln Phe Pro Val Val Ser Ile Val Ser Thr Val Ser Ala Thr
 1               5                  10                  15      
Val Ile Thr Gly Ala Leu Leu Ile Leu Leu Pro Asp Asp Ser Asn Ser
            20                  25                  30          
Asp Trp Arg Phe Val Glu Arg Leu Leu Asp Ala Thr Ile Ala Val Ser
        35                  40                  45              
Pro Val Leu Ser Ala Met Val Asn Ser Val Val Phe Phe Glu Ile Thr
    50                  55                  60                  
Arg Asp Gly Lys Pro Leu Gly Arg Ile Ser Ile Lys Leu Phe Ala Asp
65                  70                  75                  80  
Lys Ile Pro Lys Thr Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu
                85                  90                  95      
Lys Gly Phe Arg Tyr Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly
            100                 105                 110         
Phe Met Cys Gln Gly Gly Asp Phe Thr Arg Pro Asn Gly Thr Gly Asp
        115                 120                 125             
Lys Ser Ile Tyr Gly Glu Lys Phe Asp Asp Glu Asn Leu Ile Arg Lys
    130                 135                 140                 
His Thr Gly Ser Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr
145                 150                 155                 160 
Asn Gly Ser Gln Phe Phe Ile Cys Ala Ala Lys Thr Glu Trp Leu Asp
                165                 170                 175     
Gly Lys His Val Ala Phe Gly Lys Val Lys Glu Arg Val Asn Ile Val
            180                 185                 190         
Glu Ala Thr Glu His Phe Gly Tyr Arg Asn Ser Lys Thr Ser Lys Lys
        195                 200                 205             
Ile Thr Ile Ala Asp Cys Gly Gln Phe
    210                 215         


<210> 6879
<211> 183
<212> PRT
<213> Homo sapiens

<400> 6879
Met His Val Tyr Phe Asn Asn Phe Val Leu Ser Phe Ser Asp Ala Thr
 1               5                  10                  15      
Val Ala Gly Ser Pro Val Leu Ser Ala Met Val Lys Pro Ile Val Phe
            20                  25                  30          
Phe Asp Ile Ala Val Asp Ala Lys Pro Ser Gly Arg Ile Ser Ile Lys
        35                  40                  45              
Leu Phe Ala Asp Lys Ile Pro Lys Thr Ala Glu Lys Phe His Ala Leu
    50                  55                  60                  
Ser Thr Gly Glu Lys Gly Phe Cys Tyr Lys Gly Ser Cys Phe His Arg
65                  70                  75                  80  
Ile Ile Pro Arg Phe Met Cys Arg Gly Gly Asp Phe Thr His His Asn
                85                  90                  95      
Gly Thr Gly Gly Lys Phe His Asp Glu Asn Leu Ile Arg Lys His Thr
            100                 105                 110         
Gly Ser Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly
        115                 120                 125             
Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Cys Leu Asp Gly Lys
    130                 135                 140                 
His Val Ala Phe Gly Lys Val Lys Glu His Met Asn Ile Val Glu Ala
145                 150                 155                 160 
Met Glu His Phe Gly Tyr Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr
                165                 170                 175     
Ile Ala Asp Cys Gly Gln Phe
            180             


<210> 6880
<211> 164
<212> PRT
<213> Homo sapiens

<400> 6880
Met Val Asn Ser Val Val Phe Phe Asp Ile Thr Val Asp Gly Lys Pro
 1               5                  10                  15      
Leu Gly Arg Ile Ser Ile Lys Leu Phe Ala Asp Lys Ile Leu Lys Thr
            20                  25                  30          
Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Arg Tyr
        35                  40                  45              
Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly
    50                  55                  60                  
Gly Asp Phe Thr Arg His Asn Gly Thr Gly Asp Lys Ser Ile Tyr Gly
65                  70                  75                  80  
Glu Lys Phe Asp Asp Glu Asn Leu Ile Arg Lys His Thr Gly Ser Gly
                85                  90                  95      
Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe
            100                 105                 110         
Phe Ile Cys Ala Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Ala
        115                 120                 125             
Phe Gly Lys Val Lys Glu Arg Val Asn Ile Val Glu Ala Met Glu His
    130                 135                 140                 
Phe Gly Tyr Arg Asn Ser Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp
145                 150                 155                 160 
Cys Gly Gln Phe
                


<210> 6881
<211> 1858
<212> PRT
<213> Homo sapiens

<400> 6881
Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser
 1               5                  10                  15      
Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys
            20                  25                  30          
Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe
        35                  40                  45              
Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln
    50                  55                  60                  
Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr
65                  70                  75                  80  
Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln
                85                  90                  95      
Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys
            100                 105                 110         
Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu
        115                 120                 125             
Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu
    130                 135                 140                 
Gln Thr Val Thr Val Glu Glu Asp Leu Leu Thr Ala Ser Lys Met Glu
145                 150                 155                 160 
Phe His Asp Gln Gln Glu Leu Thr Pro Ser Thr Ala Glu Pro Ser Asp
                165                 170                 175     
Gln Lys Glu Lys Glu Ser Glu Lys Gln Ser Lys Pro Gly Glu Asp Leu
            180                 185                 190         
Lys His Ala Ala Leu Val Ser Gln Pro Glu Thr Thr Lys Thr Tyr Pro
        195                 200                 205             
Asp Lys Lys Asp Met Gln Gly Thr Glu Glu Glu Lys Ala Pro Leu Ala
    210                 215                 220                 
Leu Phe Gly His Thr Leu Val Ala Ser Leu Glu Asp Met Lys Gln Lys
225                 230                 235                 240 
Thr Glu Pro Ser Leu Val Val Pro Gly Ile Asp Leu Pro Lys Glu Pro
                245                 250                 255     
Pro Thr Pro Lys Glu Gln Lys Asp Trp Phe Ile Glu Met Pro Thr Glu
            260                 265                 270         
Ala Lys Lys Asp Glu Trp Gly Leu Val Ala Pro Ile Ser Pro Gly Pro
        275                 280                 285             
Leu Thr Pro Met Arg Glu Lys Asp Val Phe Asp Asp Ile Pro Lys Trp
    290                 295                 300                 
Glu Gly Lys Gln Phe Asp Ser Pro Met Pro Ser Pro Phe Gln Gly Gly
305                 310                 315                 320 
Ser Phe Thr Leu Pro Leu Asp Val Met Lys Asn Glu Ile Val Thr Glu
                325                 330                 335     
Thr Ser Pro Phe Ala Pro Ala Phe Leu Gln Pro Asp Asp Lys Lys Ser
            340                 345                 350         
Leu Gln Gln Thr Ser Gly Pro Ala Thr Ala Lys Asp Ser Phe Lys Ile
        355                 360                 365             
Glu Glu Pro His Glu Ala Lys Pro Asp Lys Met Ala Glu Ala Pro Pro
    370                 375                 380                 
Ser Glu Ala Met Thr Leu Pro Lys Asp Ala His Ile Pro Val Val Glu
385                 390                 395                 400 
Glu His Val Met Gly Lys Val Leu Glu Glu Glu Lys Glu Ala Ile Asn
                405                 410                 415     
Gln Glu Thr Val Gln Gln Arg Asp Thr Phe Thr Pro Ser Gly Gln Glu
            420                 425                 430         
Pro Ile Leu Thr Glu Lys Glu Thr Glu Leu Lys Leu Glu Glu Lys Thr
        435                 440                 445             
Thr Ile Ser Asp Lys Glu Ala Val Pro Lys Glu Ser Lys Pro Pro Lys
    450                 455                 460                 
Pro Ala Asp Glu Glu Ile Gly Ile Ile Gln Thr Ser Thr Glu His Thr
465                 470                 475                 480 
Phe Ser Glu Gln Lys Asp Gln Glu Pro Thr Thr Asp Met Leu Lys Gln
                485                 490                 495     
Asp Ser Phe Pro Val Ser Leu Glu Gln Ala Val Thr Asp Ser Ala Met
            500                 505                 510         
Thr Ser Lys Thr Leu Glu Lys Ala Met Thr Glu Pro Ser Ala Leu Ile
        515                 520                 525             
Glu Lys Ser Ser Ile Gln Glu Leu Phe Glu Met Arg Val Asp Asp Lys
    530                 535                 540                 
Asp Lys Ile Glu Gly Val Gly Ala Ala Thr Ser Ala Glu Leu Asp Met
545                 550                 555                 560 
Pro Phe Tyr Glu Asp Lys Ser Gly Met Ser Lys Tyr Phe Glu Thr Ser
                565                 570                 575     
Ala Leu Lys Glu Glu Ala Thr Lys Ser Ile Glu Pro Gly Ser Asp Tyr
            580                 585                 590         
Tyr Glu Leu Ser Asp Thr Arg Glu Ser Val His Glu Ser Ile Asp Thr
        595                 600                 605             
Met Ser Pro Met His Lys Asn Gly Asp Lys Glu Phe Gln Thr Gly Lys
    610                 615                 620                 
Glu Ser Gln Pro Ser Pro Pro Ala Gln Glu Ala Gly Tyr Ser Thr Leu
625                 630                 635                 640 
Ala Gln Ser Tyr Pro Ser Asp Leu Pro Glu Glu Pro Ser Ser Pro Gln
                645                 650                 655     
Glu Arg Met Phe Thr Ile Asp Pro Lys Val Tyr Gly Glu Lys Arg Asp
            660                 665                 670         
Leu His Ser Lys Asn Lys Asp Asp Leu Thr Leu Ser Arg Ser Leu Gly
        675                 680                 685             
Leu Gly Gly Arg Ser Ala Ile Glu Gln Arg Ser Met Ser Ile Asn Leu
    690                 695                 700                 
Pro Met Ser Cys Leu Asp Ser Ile Ala Leu Gly Phe Asn Phe Gly Arg
705                 710                 715                 720 
Gly His Asp Leu Ser Pro Leu Ala Ser Asp Ile Leu Thr Asn Thr Ser
                725                 730                 735     
Gly Ser Met Asp Glu Gly Asp Asp Tyr Leu Pro Ala Thr Thr Pro Ala
            740                 745                 750         
Leu Glu Lys Ala Pro Cys Phe Pro Val Glu Ser Lys Glu Glu Glu Gln
        755                 760                 765             
Ile Glu Lys Val Lys Ala Thr Gly Glu Glu Ser Thr Gln Ala Glu Ile
    770                 775                 780                 
Ser Cys Glu Ser Pro Phe Leu Ala Lys Asp Phe Tyr Lys Asn Gly Thr
785                 790                 795                 800 
Val Met Ala Pro Asp Leu Pro Glu Met Leu Asp Leu Ala Gly Thr Arg
                805                 810                 815     
Ser Arg Leu Ala Ser Val Ser Ala Asp Ala Glu Val Ala Arg Arg Lys
            820                 825                 830         
Ser Val Pro Ser Glu Thr Val Val Glu Asp Ser Arg Thr Gly Leu Pro
        835                 840                 845             
Pro Val Thr Asp Glu Asn His Val Ile Val Lys Thr Asp Ser Gln Leu
    850                 855                 860                 
Glu Asp Leu Gly Tyr Cys Val Phe Asn Lys Tyr Thr Val Pro Leu Pro
865                 870                 875                 880 
Ser Pro Val Gln Asp Ser Glu Asn Leu Ser Gly Glu Ser Gly Thr Phe
                885                 890                 895     
Tyr Glu Gly Thr Asp Asp Lys Val Arg Arg Asp Leu Ala Thr Asp Leu
            900                 905                 910         
Ser Leu Ile Glu Val Lys Leu Ala Ala Ala Gly Arg Val Lys Asp Glu
        915                 920                 925             
Phe Ser Val Asp Lys Glu Ala Ser Ala His Ile Ser Gly Asp Lys Ser
    930                 935                 940                 
Gly Leu Ser Lys Glu Phe Asp Gln Glu Lys Lys Ala Asn Asp Arg Leu
945                 950                 955                 960 
Asp Thr Val Leu Glu Lys Ser Glu Glu His Ala Asp Ser Lys Glu His
                965                 970                 975     
Ala Lys Lys Thr Glu Glu Ala Gly Asp Glu Ile Glu Thr Phe Gly Leu
            980                 985                 990         
Gly Val Thr Tyr Glu Gln Ala Leu Ala Lys Asp Leu Ser Ile Pro Thr
        995                 1000                1005            
Asp Ala Ser Ser Glu Lys Ala Glu Lys Gly Leu Ser Ser Val Pro Glu
    1010                1015                1020                
Ile Ala Glu Val Glu Pro Ser Lys Lys Val Glu Gln Gly Leu Asp Phe
1025                1030                1035                1040
Ala Val Gln Gly Gln Leu Asp Val Lys Ile Ser Asp Phe Gly Gln Met
                1045                1050                1055    
Ala Ser Gly Leu Asn Ile Asp Asp Arg Arg Ala Thr Glu Leu Lys Leu
            1060                1065                1070        
Glu Ala Thr Gln Asp Met Thr Pro Ser Ser Lys Ala Pro Gln Glu Ala
        1075                1080                1085            
Asp Ala Phe Met Gly Val Glu Ser Gly His Met Lys Glu Gly Thr Lys
    1090                1095                1100                
Val Ser Glu Thr Glu Val Lys Gln Lys Val Ala Lys Pro Asp Leu Val
1105                1110                1115                1120
His Gln Glu Ala Val Asp Lys Glu Glu Ser Tyr Glu Ser Ser Gly Glu
                1125                1130                1135    
His Glu Ser Leu Thr Met Glu Ser Leu Lys Ala Asp Glu Gly Lys Lys
            1140                1145                1150        
Glu Thr Ser Pro Glu Ser Ser Leu Ile Gln Asp Glu Ile Ala Val Lys
        1155                1160                1165            
Leu Ser Val Glu Ile Pro Cys Pro Pro Ala Val Ser Glu Ala Asp Leu
    1170                1175                1180                
Ala Thr Asp Glu Arg Ala Asp Val Gln Met Glu Phe Ile Gln Gly Pro
1185                1190                1195                1200
Lys Glu Glu Ser Lys Glu Thr Pro Asp Ile Ser Ile Thr Pro Ser Asp
                1205                1210                1215    
Val Ala Glu Pro Leu His Glu Thr Ile Val Ser Glu Pro Ala Glu Ile
            1220                1225                1230        
Gln Ser Glu Glu Glu Glu Ile Glu Ala Gln Gly Glu Tyr Asp Lys Leu
        1235                1240                1245            
Leu Phe Arg Ser Asp Thr Leu Gln Ile Thr Asp Leu Gly Val Ser Gly
    1250                1255                1260                
Ala Arg Glu Glu Phe Val Glu Thr Cys Pro Ser Glu His Lys Gly Val
1265                1270                1275                1280
Ile Glu Ser Val Val Thr Ile Glu Asp Asp Phe Ile Thr Val Val Gln
                1285                1290                1295    
Thr Thr Thr Asp Glu Gly Glu Ser Gly Ser His Ser Val Arg Phe Ala
            1300                1305                1310        
Ala Leu Glu Gln Pro Glu Val Glu Arg Arg Pro Ser Pro His Asp Glu
        1315                1320                1325            
Glu Glu Phe Glu Val Glu Glu Ala Ala Glu Ala Gln Ala Glu Pro Lys
    1330                1335                1340                
Asp Gly Ser Pro Glu Ala Pro Ala Ser Pro Glu Arg Glu Glu Val Ala
1345                1350                1355                1360
Leu Ser Glu Tyr Lys Thr Glu Thr Tyr Asp Asp Tyr Lys Asp Glu Thr
                1365                1370                1375    
Thr Ile Asp Asp Ser Ile Met Asp Ala Asp Ser Leu Trp Val Asp Thr
            1380                1385                1390        
Gln Asp Asp Asp Arg Ser Ile Met Thr Glu Gln Leu Glu Thr Ile Pro
        1395                1400                1405            
Lys Glu Glu Lys Ala Glu Lys Glu Ala Arg Arg Ser Ser Leu Glu Lys
    1410                1415                1420                
His Arg Lys Glu Lys Pro Phe Lys Thr Gly Arg Gly Arg Ile Ser Thr
1425                1430                1435                1440
Pro Glu Arg Lys Val Ala Lys Lys Glu Pro Ser Thr Val Ser Arg Asp
                1445                1450                1455    
Glu Val Arg Arg Lys Lys Ala Val Tyr Lys Lys Ala Glu Leu Ala Lys
            1460                1465                1470        
Lys Thr Glu Val Gln Ala His Ser Pro Ser Arg Lys Phe Ile Leu Lys
        1475                1480                1485            
Pro Ala Ile Lys Tyr Thr Arg Pro Thr His Leu Ser Cys Val Lys Arg
    1490                1495                1500                
Lys Thr Thr Ala Ala Gly Gly Glu Ser Ala Leu Ala Pro Ser Val Phe
1505                1510                1515                1520
Lys Gln Ala Lys Asp Lys Val Ser Asp Gly Val Thr Lys Ser Pro Glu
                1525                1530                1535    
Lys Arg Ser Ser Leu Pro Arg Pro Ser Ser Ile Leu Pro Pro Arg Arg
            1540                1545                1550        
Gly Val Ser Gly Asp Arg Asp Glu Asn Ser Phe Ser Leu Asn Ser Ser
        1555                1560                1565            
Ile Ser Ser Ser Ala Arg Arg Thr Thr Arg Ser Glu Pro Ile Arg Arg
    1570                1575                1580                
Ala Gly Lys Ser Gly Thr Ser Thr Pro Thr Thr Pro Gly Ser Thr Ala
1585                1590                1595                1600
Ile Thr Pro Gly Thr Pro Pro Ser Tyr Ser Ser Arg Thr Pro Gly Thr
                1605                1610                1615    
Pro Gly Thr Pro Ser Tyr Pro Arg Thr Pro His Thr Pro Gly Thr Pro
            1620                1625                1630        
Lys Ser Ala Ile Leu Val Pro Ser Glu Lys Lys Val Ala Ile Ile Arg
        1635                1640                1645            
Thr Pro Pro Lys Ser Pro Ala Thr Pro Lys Gln Leu Arg Leu Ile Asn
    1650                1655                1660                
Gln Pro Leu Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr
1665                1670                1675                1680
Asp Asn Ile Lys Tyr Gln Pro Lys Gly Gly Gln Val Arg Ile Leu Asn
                1685                1690                1695    
Lys Lys Ile Asp Phe Ser Lys Val His Ser Arg Ser Gly Ser Lys Asp
            1700                1705                1710        
Asn Ile Lys His Ser Ala Gly Gly Gly Asn Val Gln Ile Val Thr Lys
        1715                1720                1725            
Lys Ile Asp Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Lys Asn
    1730                1735                1740                
Ile Gly His Arg Pro Gly Gly Gly Arg Val Lys Ile Glu Ser Val Lys
1745                1750                1755                1760
Leu Asp Phe Lys Glu Lys Ala Gln Ala Lys Val Gly Ser Leu Asp Asn
                1765                1770                1775    
Ala His His Val Pro Gly Gly Gly Asn Val Lys Ile Asp Ser Gln Lys
            1780                1785                1790        
Leu Asn Phe Arg Glu His Ala Lys Ala Arg Val Asp His Gly Ala Glu
        1795                1800                1805            
Ile Ile Thr Gln Ser Pro Gly Arg Ser Ser Val Ala Ser Pro Arg Arg
    1810                1815                1820                
Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Leu Leu Glu Ser Pro
1825                1830                1835                1840
Gln Leu Ala Thr Leu Ala Glu Asp Val Thr Ala Ala Leu Ala Lys Gln
                1845                1850                1855    
Gly Leu
        


<210> 6882
<211> 471
<212> PRT
<213> Homo sapiens

<400> 6882
Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser
 1               5                  10                  15      
Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys
            20                  25                  30          
Asp Gln Gly Gly Arg Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe
        35                  40                  45              
Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln
    50                  55                  60                  
Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr
65                  70                  75                  80  
Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln
                85                  90                  95      
Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Ala Glu Gln Glu Lys
            100                 105                 110         
Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu
        115                 120                 125             
Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu
    130                 135                 140                 
Gln Thr Val Thr Val Glu Glu Ala Ala Gly Gly Glu Ser Ala Leu Ala
145                 150                 155                 160 
Pro Ser Val Phe Lys Gln Ala Lys Asp Lys Val Ser Asp Gly Val Thr
                165                 170                 175     
Lys Ser Pro Glu Lys Arg Ser Ser Leu Pro Arg Pro Ser Ser Ile Leu
            180                 185                 190         
Pro Pro Arg Arg Gly Val Ser Gly Asp Arg Asp Glu Asn Ser Phe Ser
        195                 200                 205             
Leu Asn Ser Ser Ile Ser Ser Ser Ala Arg Arg Thr Thr Arg Ser Glu
    210                 215                 220                 
Pro Ile Arg Arg Ala Gly Lys Ser Gly Thr Ser Thr Pro Thr Thr Pro
225                 230                 235                 240 
Gly Ser Thr Ala Ile Thr Pro Gly Thr Pro Pro Ser Tyr Ser Ser Arg
                245                 250                 255     
Thr Pro Gly Thr Pro Gly Thr Pro Ser Tyr Pro Arg Thr Pro His Thr
            260                 265                 270         
Pro Gly Thr Pro Lys Ser Ala Ile Leu Val Pro Ser Glu Lys Lys Val
        275                 280                 285             
Ala Ile Ile Arg Thr Pro Pro Lys Ser Pro Ala Thr Pro Lys Gln Leu
    290                 295                 300                 
Arg Leu Ile Asn Gln Pro Leu Pro Asp Leu Lys Asn Val Lys Ser Lys
305                 310                 315                 320 
Ile Gly Ser Thr Asp Asn Ile Lys Tyr Gln Pro Lys Gly Gly Gln Val
                325                 330                 335     
Gln Ile Val Thr Lys Lys Ile Asp Leu Ser His Val Thr Ser Lys Cys
            340                 345                 350         
Gly Ser Leu Lys Asn Ile Arg His Arg Pro Gly Gly Gly Arg Val Lys
        355                 360                 365             
Ile Glu Ser Val Lys Leu Asp Phe Lys Glu Lys Val Gln Ala Lys Val
    370                 375                 380                 
Gly Ser Leu Asp Asn Ala His His Val Pro Gly Gly Gly Asn Val Lys
385                 390                 395                 400 
Ile Asp Ser Gln Lys Leu Asn Phe Arg Glu His Ala Lys Ala Arg Val
                405                 410                 415     
Asp His Gly Ala Glu Ile Ile Thr Gln Ser Pro Gly Arg Ser Ser Val
            420                 425                 430         
Ala Ser Pro Arg Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn
        435                 440                 445             
Leu Leu Glu Ser Pro Gln Leu Ala Thr Leu Ala Glu Asp Val Thr Ala
    450                 455                 460                 
Ala Leu Ala Lys Gln Gly Leu
465                 470     


<210> 6883
<211> 1827
<212> PRT
<213> Homo sapiens

<400> 6883
Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser
 1               5                  10                  15      
Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys
            20                  25                  30          
Asp Gln Gly Gly Arg Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe
        35                  40                  45              
Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln
    50                  55                  60                  
Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr
65                  70                  75                  80  
Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln
                85                  90                  95      
Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Ala Glu Gln Glu Lys
            100                 105                 110         
Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu
        115                 120                 125             
Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu
    130                 135                 140                 
Gln Thr Val Thr Val Glu Glu Asp Leu Leu Thr Ala Ser Lys Met Glu
145                 150                 155                 160 
Phe His Asp Gln Gln Glu Leu Thr Pro Ser Thr Ala Glu Pro Ser Asp
                165                 170                 175     
Gln Lys Glu Lys Glu Ser Glu Lys Gln Ser Ser Pro Gly Glu Asp Leu
            180                 185                 190         
Lys His Ala Ala Leu Val Ser Gln Pro Glu Thr Thr Lys Thr Tyr Pro
        195                 200                 205             
Asp Lys Lys Asp Met Gln Gly Thr Glu Glu Glu Lys Ala Pro Leu Ala
    210                 215                 220                 
Leu Phe Gly His Thr Leu Val Ala Ser Leu Glu Asp Met Lys Gln Lys
225                 230                 235                 240 
Thr Glu Pro Ser Leu Val Val Pro Gly Ile Asp Leu Pro Lys Glu Pro
                245                 250                 255     
Pro Thr Pro Lys Glu Gln Lys Asp Trp Phe Ile Glu Met Pro Thr Glu
            260                 265                 270         
Ala Lys Lys Asp Glu Trp Gly Leu Val Ala Pro Ile Ser Pro Gly Pro
        275                 280                 285             
Leu Thr Pro Met Arg Glu Lys Asp Val Phe Asp Asp Ile Pro Lys Trp
    290                 295                 300                 
Glu Gly Lys Gln Phe Asp Ser Pro Met Pro Ser Pro Phe Gln Gly Gly
305                 310                 315                 320 
Ser Phe Thr Leu Pro Leu Asp Val Met Lys Asn Glu Ile Val Thr Glu
                325                 330                 335     
Thr Ser Pro Phe Ala Pro Ala Phe Leu Gln Pro Asp Asp Lys Lys Ser
            340                 345                 350         
Leu Gln Gln Thr Ser Gly Pro Ala Thr Ala Lys Asp Ser Phe Lys Ile
        355                 360                 365             
Glu Glu Pro His Glu Ala Lys Pro Asp Lys Met Ala Glu Ala Pro Pro
    370                 375                 380                 
Ser Glu Ala Met Thr Leu Pro Lys Asp Ala His Ile Pro Val Val Glu
385                 390                 395                 400 
Glu His Val Met Gly Lys Val Leu Glu Glu Glu Lys Glu Ala Ile Asn
                405                 410                 415     
Gln Glu Thr Val Gln Gln Arg Asp Thr Phe Thr Pro Ser Gly Gln Glu
            420                 425                 430         
Pro Ile Leu Thr Glu Lys Glu Thr Glu Leu Lys Leu Glu Glu Lys Thr
        435                 440                 445             
Thr Ile Ser Asp Lys Glu Ala Val Pro Lys Glu Ser Lys Pro Pro Lys
    450                 455                 460                 
Pro Ala Asp Glu Glu Ile Gly Ile Ile Gln Thr Ser Thr Glu His Thr
465                 470                 475                 480 
Phe Ser Glu Gln Lys Asp Gln Glu Pro Thr Thr Asp Met Leu Lys Gln
                485                 490                 495     
Asp Ser Phe Pro Val Ser Leu Glu Gln Ala Val Thr Asp Ser Ala Met
            500                 505                 510         
Thr Ser Lys Thr Leu Glu Lys Ala Met Thr Glu Pro Ser Ala Leu Ile
        515                 520                 525             
Glu Lys Ser Ser Ile Gln Glu Leu Phe Glu Met Arg Val Asp Asp Lys
    530                 535                 540                 
Asp Lys Ile Glu Gly Val Gly Ala Ala Thr Ser Ala Glu Leu Asp Met
545                 550                 555                 560 
Pro Phe Tyr Glu Asp Lys Ser Gly Met Ser Lys Tyr Phe Glu Thr Ser
                565                 570                 575     
Ala Leu Lys Glu Glu Ala Thr Lys Ser Ile Glu Pro Gly Ser Asp Tyr
            580                 585                 590         
Tyr Glu Leu Ser Asp Thr Arg Glu Ser Val His Glu Ser Ile Asp Thr
        595                 600                 605             
Met Ser Pro Met His Lys Asn Gly Asp Lys Glu Phe Gln Thr Gly Lys
    610                 615                 620                 
Glu Ser Gln Pro Ser Pro Pro Ala Gln Glu Ala Gly Tyr Ser Thr Leu
625                 630                 635                 640 
Ala Gln Ser Tyr Pro Ser Asp Leu Pro Glu Glu Pro Ser Ser Pro Gln
                645                 650                 655     
Glu Arg Met Phe Thr Ile Asp Pro Lys Val Tyr Gly Glu Lys Arg Asp
            660                 665                 670         
Leu His Ser Lys Asn Lys Asp Asp Leu Thr Leu Ser Arg Ser Leu Gly
        675                 680                 685             
Leu Gly Gly Arg Ser Ala Ile Glu Gln Arg Ser Met Ser Ile Asn Leu
    690                 695                 700                 
Pro Met Ser Cys Leu Asp Ser Ile Ala Leu Gly Phe Asn Phe Gly Arg
705                 710                 715                 720 
Gly His Asp Leu Ser Pro Leu Ala Ser Asp Ile Leu Thr Asn Thr Ser
                725                 730                 735     
Gly Ser Met Asp Glu Gly Asp Asp Tyr Leu Pro Ala Thr Thr Pro Ala
            740                 745                 750         
Leu Glu Lys Ala Pro Cys Phe Pro Val Glu Ser Lys Glu Glu Glu Gln
        755                 760                 765             
Ile Glu Lys Val Lys Ala Thr Gly Glu Glu Ser Thr Gln Ala Glu Ile
    770                 775                 780                 
Ser Cys Glu Ser Pro Phe Leu Ala Lys Asp Phe Tyr Lys Asn Gly Thr
785                 790                 795                 800 
Val Met Ala Pro Asp Leu Pro Glu Met Leu Asp Leu Ala Gly Thr Arg
                805                 810                 815     
Ser Arg Leu Ala Ser Val Ser Ala Asp Ala Glu Val Ala Arg Arg Lys
            820                 825                 830         
Ser Val Pro Ser Glu Thr Val Val Glu Asp Ser Arg Thr Gly Leu Pro
        835                 840                 845             
Pro Val Thr Asp Glu Asn His Val Ile Val Lys Thr Asp Ser Gln Leu
    850                 855                 860                 
Glu Asp Leu Gly Tyr Cys Val Phe Asn Lys Tyr Thr Val Pro Leu Pro
865                 870                 875                 880 
Ser Pro Val Gln Asp Ser Glu Asn Leu Ser Gly Glu Ser Gly Thr Phe
                885                 890                 895     
Tyr Glu Gly Thr Asp Asp Lys Val Arg Arg Asp Leu Ala Thr Asp Leu
            900                 905                 910         
Ser Leu Ile Glu Val Lys Leu Ala Ala Ala Gly Arg Val Lys Asp Glu
        915                 920                 925             
Phe Ser Val Asp Lys Glu Ala Ser Ala His Ile Ser Gly Asp Lys Ser
    930                 935                 940                 
Gly Leu Ser Lys Glu Phe Asp Gln Glu Lys Lys Ala Asn Asp Arg Leu
945                 950                 955                 960 
Asp Thr Val Leu Glu Lys Ser Glu Glu His Ala Asp Ser Lys Glu His
                965                 970                 975     
Ala Lys Lys Thr Glu Glu Ala Gly Asp Glu Ile Glu Thr Phe Gly Leu
            980                 985                 990         
Gly Val Thr Tyr Glu Gln Ala Leu Ala Lys Asp Leu Ser Ile Pro Thr
        995                 1000                1005            
Asp Ala Ser Ser Glu Lys Ala Glu Lys Gly Leu Ser Ser Val Pro Glu
    1010                1015                1020                
Ile Ala Glu Val Glu Pro Ser Lys Lys Val Glu Gln Gly Leu Asp Phe
1025                1030                1035                1040
Ala Val Gln Gly Gln Leu Asp Val Lys Ile Ser Asp Phe Gly Gln Met
                1045                1050                1055    
Ala Ser Gly Leu Asn Ile Asp Asp Arg Arg Ala Thr Glu Leu Lys Leu
            1060                1065                1070        
Glu Ala Thr Gln Asp Met Thr Pro Ser Ser Lys Ala Pro Gln Glu Ala
        1075                1080                1085            
Asp Ala Phe Met Gly Val Glu Ser Gly His Met Lys Glu Gly Thr Lys
    1090                1095                1100                
Val Ser Glu Thr Glu Val Lys Gln Lys Val Ala Lys Pro Asp Leu Val
1105                1110                1115                1120
His Gln Glu Ala Val Asp Lys Glu Glu Ser Tyr Glu Ser Ser Gly Glu
                1125                1130                1135    
His Glu Ser Leu Thr Met Glu Ser Leu Lys Ala Asp Glu Gly Lys Lys
            1140                1145                1150        
Glu Thr Ser Pro Glu Ser Ser Leu Ile Gln Asp Glu Ile Ala Val Lys
        1155                1160                1165            
Leu Ser Val Glu Ile Pro Cys Pro Pro Ala Val Ser Glu Ala Asp Leu
    1170                1175                1180                
Ala Thr Asp Glu Arg Ala Asp Val Gln Met Glu Phe Ile Gln Gly Pro
1185                1190                1195                1200
Lys Glu Glu Ser Lys Glu Thr Pro Asp Ile Ser Ile Thr Pro Ser Asp
                1205                1210                1215    
Val Ala Glu Pro Leu His Glu Thr Ile Val Ser Glu Pro Ala Glu Ile
            1220                1225                1230        
Gln Ser Glu Glu Glu Glu Ile Glu Ala Gln Gly Glu Tyr Asp Lys Leu
        1235                1240                1245            
Leu Phe Arg Ser Asp Thr Leu Gln Ile Thr Asp Leu Gly Val Ser Gly
    1250                1255                1260                
Ala Arg Glu Glu Phe Val Glu Thr Cys Pro Ser Glu His Lys Gly Val
1265                1270                1275                1280
Ile Glu Ser Val Val Thr Ile Glu Asp Asp Phe Ile Thr Val Val Gln
                1285                1290                1295    
Thr Thr Thr Asp Glu Gly Glu Ser Gly Ser His Ser Val Arg Phe Ala
            1300                1305                1310        
Ala Leu Glu Gln Pro Glu Val Glu Arg Arg Pro Ser Pro His Asp Glu
        1315                1320                1325            
Glu Glu Phe Glu Val Glu Glu Ala Ala Glu Ala Gln Ala Glu Pro Lys
    1330                1335                1340                
Asp Gly Ser Pro Glu Ala Pro Ala Ser Pro Glu Arg Glu Glu Val Ala
1345                1350                1355                1360
Leu Ser Glu Tyr Lys Thr Glu Thr Tyr Asp Asp Tyr Lys Asp Glu Thr
                1365                1370                1375    
Thr Ile Asp Asp Ser Ile Met Asp Ala Asp Ser Leu Trp Val Asp Thr
            1380                1385                1390        
Gln Asp Asp Asp Arg Ser Ile Met Thr Glu Gln Leu Glu Thr Ile Pro
        1395                1400                1405            
Lys Glu Glu Lys Ala Glu Lys Glu Ala Arg Arg Ser Ser Leu Glu Lys
    1410                1415                1420                
His Arg Lys Glu Lys Pro Phe Lys Thr Gly Arg Gly Arg Ile Ser Thr
1425                1430                1435                1440
Pro Glu Arg Lys Val Ala Lys Lys Glu Pro Ser Thr Val Ser Arg Asp
                1445                1450                1455    
Glu Val Arg Arg Lys Lys Ala Val Tyr Lys Lys Ala Glu Leu Ala Lys
            1460                1465                1470        
Lys Thr Glu Val Gln Ala His Ser Pro Ser Arg Lys Phe Ile Leu Lys
        1475                1480                1485            
Pro Ala Ile Lys Tyr Thr Arg Pro Thr His Leu Ser Cys Val Lys Arg
    1490                1495                1500                
Lys Thr Thr Ala Ala Gly Gly Glu Ser Ala Leu Ala Pro Ser Val Phe
1505                1510                1515                1520
Lys Gln Ala Lys Asp Lys Val Ser Asp Gly Val Thr Lys Ser Pro Glu
                1525                1530                1535    
Lys Arg Ser Ser Leu Pro Arg Pro Ser Ser Ile Leu Pro Pro Arg Arg
            1540                1545                1550        
Gly Val Ser Gly Asp Arg Asp Glu Asn Ser Phe Ser Leu Asn Ser Ser
        1555                1560                1565            
Ile Ser Ser Ser Ala Arg Arg Thr Thr Arg Ser Glu Pro Ile Arg Arg
    1570                1575                1580                
Ala Gly Lys Ser Gly Thr Ser Thr Pro Thr Thr Pro Gly Ser Thr Ala
1585                1590                1595                1600
Ile Thr Pro Gly Thr Pro Pro Ser Tyr Ser Ser Arg Thr Pro Gly Thr
                1605                1610                1615    
Pro Gly Thr Pro Ser Tyr Pro Arg Thr Pro His Thr Pro Gly Thr Pro
            1620                1625                1630        
Lys Ser Ala Ile Leu Val Pro Ser Glu Lys Lys Val Ala Ile Ile Arg
        1635                1640                1645            
Thr Pro Pro Lys Ser Pro Ala Thr Pro Lys Gln Leu Arg Leu Ile Asn
    1650                1655                1660                
Gln Pro Leu Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr
1665                1670                1675                1680
Asp Asn Ile Lys Tyr Gln Pro Lys Gly Gly Gln Val Gln Ile Val Thr
                1685                1690                1695    
Lys Lys Ile Asp Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Lys
            1700                1705                1710        
Asn Ile Arg His Arg Pro Gly Gly Gly Arg Val Lys Ile Glu Ser Val
        1715                1720                1725            
Lys Leu Asp Phe Lys Glu Lys Val Gln Ala Lys Val Gly Ser Leu Asp
    1730                1735                1740                
Asn Ala His His Val Pro Gly Gly Gly Asn Val Lys Ile Asp Ser Gln
1745                1750                1755                1760
Lys Leu Asn Phe Arg Glu His Ala Lys Ala Arg Val Asp His Gly Ala
                1765                1770                1775    
Glu Ile Ile Thr Gln Ser Pro Gly Arg Ser Ser Val Ala Ser Pro Arg
            1780                1785                1790        
Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Leu Leu Glu Ser
        1795                1800                1805            
Pro Gln Leu Ala Thr Leu Ala Glu Asp Val Thr Ala Ala Leu Ala Lys
    1810                1815                1820                
Gln Gly Leu
1825        


<210> 6884
<211> 502
<212> PRT
<213> Homo sapiens

<400> 6884
Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser
 1               5                  10                  15      
Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys
            20                  25                  30          
Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe
        35                  40                  45              
Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln
    50                  55                  60                  
Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr
65                  70                  75                  80  
Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln
                85                  90                  95      
Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys
            100                 105                 110         
Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu
        115                 120                 125             
Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu
    130                 135                 140                 
Gln Thr Val Thr Val Glu Glu Ala Ala Gly Gly Glu Ser Ala Leu Ala
145                 150                 155                 160 
Pro Ser Val Phe Lys Gln Ala Lys Asp Lys Val Ser Asp Gly Val Thr
                165                 170                 175     
Lys Ser Pro Glu Lys Arg Ser Ser Leu Pro Arg Pro Ser Ser Ile Leu
            180                 185                 190         
Pro Pro Arg Arg Gly Val Ser Gly Asp Arg Asp Glu Asn Ser Phe Ser
        195                 200                 205             
Leu Asn Ser Ser Ile Ser Ser Ser Ala Arg Arg Thr Thr Arg Ser Glu
    210                 215                 220                 
Pro Ile Arg Arg Ala Gly Lys Ser Gly Thr Ser Thr Pro Thr Thr Pro
225                 230                 235                 240 
Gly Ser Thr Ala Ile Thr Pro Gly Thr Pro Pro Ser Tyr Ser Ser Arg
                245                 250                 255     
Thr Pro Gly Thr Pro Gly Thr Pro Ser Tyr Pro Arg Thr Pro His Thr
            260                 265                 270         
Pro Gly Thr Pro Lys Ser Ala Ile Leu Val Pro Ser Glu Lys Lys Val
        275                 280                 285             
Ala Ile Ile Arg Thr Pro Pro Lys Ser Pro Ala Thr Pro Lys Gln Leu
    290                 295                 300                 
Arg Leu Ile Asn Gln Pro Leu Pro Asp Leu Lys Asn Val Lys Ser Lys
305                 310                 315                 320 
Ile Gly Ser Thr Asp Asn Ile Lys Tyr Gln Pro Lys Gly Gly Gln Val
                325                 330                 335     
Arg Ile Leu Asn Lys Lys Ile Asp Phe Ser Lys Val His Ser Arg Ser
            340                 345                 350         
Gly Ser Lys Asp Asn Ile Lys His Ser Ala Gly Gly Gly Asn Val Gln
        355                 360                 365             
Ile Val Thr Lys Lys Ile Asp Leu Ser His Val Thr Ser Lys Cys Gly
    370                 375                 380                 
Ser Leu Lys Asn Ile Gly His Arg Pro Gly Gly Gly Arg Val Lys Ile
385                 390                 395                 400 
Glu Ser Val Lys Leu Asp Phe Lys Glu Lys Ala Gln Ala Lys Val Gly
                405                 410                 415     
Ser Leu Asp Asn Ala His His Val Pro Gly Gly Gly Asn Val Lys Ile
            420                 425                 430         
Asp Ser Gln Lys Leu Asn Phe Arg Glu His Ala Lys Ala Arg Val Asp
        435                 440                 445             
His Gly Ala Glu Ile Ile Thr Gln Ser Pro Gly Arg Ser Ser Val Ala
    450                 455                 460                 
Ser Pro Arg Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Leu
465                 470                 475                 480 
Leu Glu Ser Pro Gln Leu Ala Thr Leu Ala Glu Asp Val Thr Ala Ala
                485                 490                 495     
Leu Ala Lys Gln Gly Leu
            500         


<210> 6885
<211> 559
<212> PRT
<213> Homo sapiens

<400> 6885
Met Ala Asp Glu Arg Lys Asp Glu Ala Lys Ala Pro His Trp Thr Ser
 1               5                  10                  15      
Ala Pro Leu Thr Glu Ala Ser Ala His Ser His Pro Pro Glu Ile Lys
            20                  25                  30          
Asp Gln Gly Gly Ala Gly Glu Gly Leu Val Arg Ser Ala Asn Gly Phe
        35                  40                  45              
Pro Tyr Arg Glu Asp Glu Glu Gly Ala Phe Gly Glu His Gly Ser Gln
    50                  55                  60                  
Gly Thr Tyr Ser Asn Thr Lys Glu Asn Gly Ile Asn Gly Glu Leu Thr
65                  70                  75                  80  
Ser Ala Asp Arg Glu Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln
                85                  90                  95      
Val Val Thr Ala Glu Ala Val Ala Val Leu Lys Gly Glu Gln Glu Lys
            100                 105                 110         
Glu Ala Gln His Lys Asp Gln Thr Ala Ala Leu Pro Leu Ala Ala Glu
        115                 120                 125             
Glu Thr Ala Asn Leu Pro Pro Ser Pro Pro Pro Ser Pro Ala Ser Glu
    130                 135                 140                 
Gln Thr Val Thr Val Glu Glu Ala Ala Gly Gly Glu Ser Ala Leu Ala
145                 150                 155                 160 
Pro Ser Val Phe Lys Gln Ala Lys Asp Lys Val Ser Asn Ser Thr Leu
                165                 170                 175     
Ser Lys Ile Pro Ala Leu Gln Gly Ser Thr Lys Ser Pro Arg Tyr Ser
            180                 185                 190         
Ser Ala Cys Pro Ser Thr Thr Lys Arg Ala Thr Phe Ser Asp Ser Leu
        195                 200                 205             
Leu Ile Gln Pro Thr Ser Ala Gly Ser Thr Asp Arg Leu Pro Tyr Ser
    210                 215                 220                 
Lys Ser Gly Asn Lys Asp Gly Val Thr Lys Ser Pro Glu Lys Arg Ser
225                 230                 235                 240 
Ser Leu Pro Arg Pro Ser Ser Ile Leu Pro Pro Arg Arg Gly Val Ser
                245                 250                 255     
Gly Asp Arg Asp Glu Asn Ser Phe Ser Leu Asn Ser Ser Ile Ser Ser
            260                 265                 270         
Ser Ala Arg Arg Thr Thr Arg Ser Glu Pro Ile Arg Arg Ala Gly Lys
        275                 280                 285             
Ser Gly Thr Ser Thr Pro Thr Thr Pro Gly Ser Thr Ala Ile Thr Pro
    290                 295                 300                 
Gly Thr Pro Pro Ser Tyr Ser Ser Arg Thr Pro Gly Thr Pro Gly Thr
305                 310                 315                 320 
Pro Ser Tyr Pro Arg Thr Pro His Thr Pro Gly Thr Pro Lys Ser Ala
                325                 330                 335     
Ile Leu Val Pro Ser Glu Lys Lys Val Ala Ile Ile Arg Thr Pro Pro
            340                 345                 350         
Lys Ser Pro Ala Thr Pro Lys Gln Leu Arg Leu Ile Asn Gln Pro Leu
        355                 360                 365             
Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Asp Asn Ile
    370                 375                 380                 
Lys Tyr Gln Pro Lys Gly Gly Gln Val Arg Ile Leu Asn Lys Lys Ile
385                 390                 395                 400 
Asp Phe Ser Lys Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys
                405                 410                 415     
His Ser Ala Gly Gly Gly Asn Val Gln Ile Val Thr Lys Lys Ile Asp
            420                 425                 430         
Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Lys Asn Ile Arg His
        435                 440                 445             
Arg Pro Gly Gly Gly Arg Val Lys Ile Glu Ser Val Lys Leu Asp Phe
    450                 455                 460                 
Lys Glu Lys Ala Gln Ala Lys Val Gly Ser Leu Asp Asn Ala His His
465                 470                 475                 480 
Val Pro Gly Gly Gly Asn Val Lys Ile Asp Ser Gln Lys Leu Asn Phe
                485                 490                 495     
Arg Glu His Ala Lys Ala Arg Val Asp His Gly Ala Glu Ile Ile Thr
            500                 505                 510         
Gln Ser Pro Gly Arg Ser Ser Val Ala Ser Pro Arg Arg Leu Ser Asn
        515                 520                 525             
Val Ser Ser Ser Gly Ser Ile Asn Leu Leu Glu Ser Pro Gln Leu Ala
    530                 535                 540                 
Thr Leu Ala Glu Asp Val Thr Ala Ala Leu Ala Lys Gln Gly Leu
545                 550                 555                 


<210> 6886
<211> 644
<212> PRT
<213> Homo sapiens

<400> 6886
Met Glu Ala Glu Arg Gly Pro Glu Arg Arg Pro Ala Glu Arg Ser Ser
 1               5                  10                  15      
Pro Gly Gln Thr Pro Glu Glu Gly Ala Gln Ala Leu Ala Glu Phe Ala
            20                  25                  30          
Ala Leu His Gly Pro Ala Leu Arg Ala Ser Gly Val Pro Glu Arg Tyr
        35                  40                  45              
Trp Gly Arg Leu Leu His Lys Leu Glu His Glu Val Phe Asp Ala Gly
    50                  55                  60                  
Glu Val Phe Gly Ile Met Gln Val Glu Glu Val Glu Glu Glu Glu Asp
65                  70                  75                  80  
Glu Ala Ala Arg Glu Val Arg Lys Gln Gln Pro Asn Pro Gly Asn Glu
                85                  90                  95      
Leu Cys Tyr Lys Val Ile Val Thr Arg Glu Ser Gly Leu Gln Ala Ala
            100                 105                 110         
His Pro Asn Ser Ile Phe Leu Ile Asp His Ala Trp Thr Cys Arg Val
        115                 120                 125             
Glu His Ala Arg Gln Gln Leu Gln Gln Val Pro Gly Leu Leu His Arg
    130                 135                 140                 
Met Ala Asn Leu Met Gly Ile Glu Phe His Gly Glu Leu Pro Ser Thr
145                 150                 155                 160 
Glu Ala Val Ala Leu Val Leu Glu Glu Met Trp Lys Phe Asn Gln Thr
                165                 170                 175     
Tyr Gln Leu Ala His Gly Thr Ala Glu Glu Lys Met Pro Val Trp Tyr
            180                 185                 190         
Ile Met Asp Glu Phe Gly Ser Arg Ile Gln His Ala Asp Val Pro Ser
        195                 200                 205             
Phe Ala Thr Ala Pro Phe Phe Tyr Met Pro Gln Gln Val Ala Tyr Thr
    210                 215                 220                 
Leu Leu Trp Pro Leu Arg Asp Leu Asp Thr Gly Glu Glu Val Thr Arg
225                 230                 235                 240 
Asp Phe Ala Tyr Gly Glu Thr Asp Pro Leu Ile Arg Lys Cys Met Leu
                245                 250                 255     
Leu Pro Trp Ala Pro Thr Asp Met Leu Asp Leu Ser Ser Cys Thr Pro
            260                 265                 270         
Glu Pro Pro Ala Glu His Tyr Gln Ala Ile Leu Glu Glu Asn Lys Glu
        275                 280                 285             
Lys Leu Pro Leu Asp Ile Asn Pro Val Val His Pro His Gly His Ile
    290                 295                 300                 
Phe Lys Val Tyr Thr Asp Val Gln Gln Val Ala Ser Ser Leu Thr His
305                 310                 315                 320 
Pro Arg Phe Thr Leu Thr Gln Ser Glu Ala Asp Ala Asp Ile Leu Phe
                325                 330                 335     
Asn Phe Ser His Phe Lys Asp Tyr Arg Lys Leu Ser Gln Glu Arg Pro
            340                 345                 350         
Gly Val Leu Leu Asn Gln Phe Pro Cys Glu Asn Leu Leu Thr Val Lys
        355                 360                 365             
Asp Cys Leu Ala Ser Ile Ala Arg Arg Ala Gly Gly Pro Glu Gly Pro
    370                 375                 380                 
Pro Trp Leu Pro Arg Thr Phe Asn Leu Arg Thr Glu Leu Pro Gln Phe
385                 390                 395                 400 
Val Ser Tyr Phe Gln Gln Arg Glu Arg Trp Gly Glu Asp Asn His Trp
                405                 410                 415     
Ile Cys Lys Pro Trp Asn Leu Ala Arg Ser Leu Asp Thr His Val Thr
            420                 425                 430         
Lys Ser Leu His Ser Ile Ile Arg His Arg Glu Ser Thr Pro Lys Val
        435                 440                 445             
Val Ser Lys Tyr Ile Glu Ser Pro Val Leu Phe Leu Arg Glu Asp Val
    450                 455                 460                 
Gly Lys Val Lys Phe Asp Ile Arg Tyr Ile Val Leu Leu Arg Ser Val
465                 470                 475                 480 
Arg Pro Leu Arg Leu Phe Val Tyr Asp Val Phe Trp Leu Arg Phe Ser
                485                 490                 495     
Asn Arg Ala Phe Ala Leu Asn Asp Leu Asp Asp Tyr Glu Lys His Phe
            500                 505                 510         
Thr Val Met Asn Tyr Asp Pro Asp Val Val Leu Lys Gln Val His Cys
        515                 520                 525             
Glu Glu Phe Ile Pro Glu Phe Glu Lys Gln Tyr Pro Glu Phe Pro Trp
    530                 535                 540                 
Thr Asp Val Gln Ala Glu Ile Phe Arg Ala Phe Thr Glu Leu Phe Gln
545                 550                 555                 560 
Val Ala Cys Ala Lys Pro Pro Pro Leu Gly Leu Cys Asp Tyr Pro Ser
                565                 570                 575     
Ser Arg Ala Met Tyr Ala Val Asp Leu Met Leu Lys Trp Asp Asn Gly
            580                 585                 590         
Pro Asp Gly Arg Arg Val Met Gln Pro Gln Ile Leu Glu Val Asn Phe
        595                 600                 605             
Asn Pro Asp Cys Glu Arg Ala Cys Arg Tyr His Pro Thr Phe Phe Asn
    610                 615                 620                 
Asp Val Phe Ser Thr Leu Phe Leu Asp Gln Pro Gly Gly Cys His Val
625                 630                 635                 640 
Thr Cys Leu Val
                


<210> 6887
<211> 896
<212> PRT
<213> Homo sapiens

<400> 6887
Met Ala Ala Arg Ala Val Leu Asp Glu Phe Thr Ala Pro Ala Glu Lys
 1               5                  10                  15      
Ala Glu Leu Leu Glu Gln Ser Arg Gly Arg Ile Glu Gly Leu Phe Gly
            20                  25                  30          
Val Ser Leu Ala Val Leu Gly Ala Leu Gly Ala Glu Glu Pro Leu Pro
        35                  40                  45              
Ala Arg Ile Trp Leu Gln Leu Cys Gly Ala Gln Glu Ala Glu His Ser
    50                  55                  60                  
Ala Lys Glu Tyr Ile Lys Gly Ile Cys Glu Pro Glu Leu Glu Glu Arg
65                  70                  75                  80  
Glu Cys Tyr Pro Lys Asp Met His Cys Ile Phe Val Gly Ala Glu Ser
                85                  90                  95      
Leu Phe Leu Lys Ser Leu Ile Gln Asp Thr Cys Ala Asp Leu Cys Ile
            100                 105                 110         
Leu Asp Ile Gly Leu Leu Gly Ile Arg Gly Ser Ala Glu Ala Val Val
        115                 120                 125             
Met Ala Arg Ser His Ile Gln Gln Phe Val Lys Leu Phe Glu Asn Lys
    130                 135                 140                 
Glu Asn Leu Pro Ser Ser Gln Lys Glu Ser Glu Val Lys Arg Glu Phe
145                 150                 155                 160 
Lys Gln Phe Val Glu Ala His Ala Asp Asn Tyr Thr Met Asp Leu Leu
                165                 170                 175     
Ile Leu Pro Thr Ser Leu Lys Lys Glu Leu Leu Thr Leu Thr Gln Gly
            180                 185                 190         
Glu Glu Asn Leu Phe Glu Thr Gly Asp Asp Glu Val Ile Glu Met Arg
        195                 200                 205             
Asp Ser Gln Gln Thr Glu Phe Thr Gln Asn Ala Ala Thr Gly Leu Asn
    210                 215                 220                 
Ile Ser Arg Asp Glu Thr Val Leu Gln Glu Glu Ala Arg Asn Lys Ala
225                 230                 235                 240 
Gly Thr Pro Val Ser Glu Leu Thr Lys Gln Met Asp Thr Val Leu Ser
                245                 250                 255     
Ser Ser Pro Asp Val Leu Phe Asp Pro Ile Asn Gly Leu Thr Pro Asp
            260                 265                 270         
Glu Glu Ala Leu Ser Asn Glu Arg Ile Cys Gln Lys Arg Arg Phe Ser
        275                 280                 285             
Asp Ser Glu Glu Arg His Thr Lys Lys Gln Phe Ser Leu Glu Asn Val
    290                 295                 300                 
Gln Glu Gly Glu Ile Leu His Asp Ala Lys Thr Leu Ala Gly Asn Val
305                 310                 315                 320 
Ile Ala Asp Leu Ser Asp Ser Ser Ala Asp Ser Glu Asn Leu Ser Pro
                325                 330                 335     
Asp Ile Lys Glu Thr Thr Glu Glu Met Glu Tyr Asn Ile Leu Val Asn
            340                 345                 350         
Phe Phe Lys Thr Met Gly Tyr Ser Gln Glu Ile Val Glu Lys Val Ile
        355                 360                 365             
Lys Val Tyr Gly Pro Ser Thr Glu Pro Leu Leu Leu Leu Glu Glu Ile
    370                 375                 380                 
Glu Lys Glu Asn Lys Arg Phe Gln Glu Asp Arg Glu Phe Ser Ala Gly
385                 390                 395                 400 
Thr Val Tyr Pro Glu Thr Asn Lys Thr Lys Asn Lys Gly Val Tyr Ser
                405                 410                 415     
Ser Thr Asn Glu Leu Thr Thr Asp Ser Thr Pro Lys Lys Thr Gln Ala
            420                 425                 430         
His Thr Gln Gln Asn Met Val Glu Lys Phe Ser Gln Leu Pro Phe Lys
        435                 440                 445             
Val Glu Ala Lys Pro Cys Thr Ser Asn Cys Arg Ile Asn Thr Phe Arg
    450                 455                 460                 
Thr Val Pro Ile Glu Gln Lys His Glu Val Trp Gly Ser Asn Gln Asn
465                 470                 475                 480 
Tyr Ile Cys Asn Thr Asp Pro Glu Thr Asp Gly Leu Ser Pro Ser Val
                485                 490                 495     
Ala Ser Pro Ser Pro Lys Glu Val Asn Phe Val Ser Arg Gly Ala Ser
            500                 505                 510         
Ser His Gln Pro Arg Val Pro Leu Phe Pro Glu Asn Gly Leu His Gln
        515                 520                 525             
Gln Pro Glu Pro Leu Leu Pro Asn Asn Met Lys Ser Ala Cys Glu Lys
    530                 535                 540                 
Arg Leu Gly Cys Cys Ser Ser Pro His Ser Lys Pro Asn Cys Ser Thr
545                 550                 555                 560 
Leu Ser Pro Pro Met Pro Leu Pro Gln Leu Leu Pro Ser Val Thr Asp
                565                 570                 575     
Ala Arg Ser Ala Gly Pro Ser Asp His Ile Asp Ser Ser Val Thr Gly
            580                 585                 590         
Val Gln Arg Phe Arg Asp Thr Leu Lys Ile Pro Tyr Lys Leu Glu Leu
        595                 600                 605             
Lys Asn Glu Pro Gly Arg Thr Asp Leu Lys His Ile Val Ile Asp Gly
    610                 615                 620                 
Ser Asn Val Ala Ile Thr His Gly Leu Lys Lys Phe Phe Ser Cys Arg
625                 630                 635                 640 
Gly Ile Ala Ile Ala Val Glu Tyr Phe Trp Lys Leu Gly Asn Arg Asn
                645                 650                 655     
Ile Thr Val Phe Val Pro Gln Trp Arg Thr Arg Arg Asp Pro Asn Val
            660                 665                 670         
Thr Glu Gln His Phe Leu Thr Gln Leu Gln Glu Leu Gly Ile Leu Ser
        675                 680                 685             
Leu Thr Pro Ala Arg Met Val Phe Gly Glu Arg Ile Ala Ser His Asp
    690                 695                 700                 
Asp Arg Phe Leu Leu His Leu Ala Asp Lys Thr Gly Gly Ile Ile Val
705                 710                 715                 720 
Thr Asn Asp Asn Phe Arg Glu Phe Val Asn Glu Ser Val Ser Trp Arg
                725                 730                 735     
Glu Ile Ile Thr Lys Arg Leu Leu Gln Tyr Thr Phe Val Gly Asp Ile
            740                 745                 750         
Phe Met Val Pro Asp Asp Pro Leu Gly Arg Ser Gly Pro Arg Leu Glu
        755                 760                 765             
Glu Phe Leu Gln Lys Glu Val Cys Leu Arg Asp Met Gln Pro Leu Leu
    770                 775                 780                 
Ser Ala Leu Pro Asn Val Gly Met Phe Asp Pro Ser Phe Arg Val Pro
785                 790                 795                 800 
Gly Thr Gln Ala Ala Ser Thr Ser His Gln Pro Pro Thr Arg Ile Gln
                805                 810                 815     
Gly Ala Pro Ser Ser His Trp Leu Pro Gln Gln Pro His Phe Pro Leu
            820                 825                 830         
Leu Pro Ala Leu Pro Ser Leu Gln Gln Asn Leu Pro Met Pro Ala Gln
        835                 840                 845             
Arg Ser Ser Ala Glu Thr Asn Glu Leu Arg Glu Ala Leu Leu Lys Ile
    850                 855                 860                 
Phe Pro Asp Ser Glu Gln Arg Leu Lys Ile Asp Gln Ile Leu Val Ala
865                 870                 875                 880 
His Pro Tyr Met Lys Asp Leu Asn Ala Leu Ser Ala Met Val Leu Asp
                885                 890                 895     


<210> 6888
<211> 907
<212> PRT
<213> Homo sapiens

<400> 6888
Met Glu Ser Ala Ile Ala Glu Gly Gly Ala Ser Arg Phe Ser Ala Ser
 1               5                  10                  15      
Ser Gly Gly Gly Gly Ser Arg Gly Ala Pro Gln His Tyr Pro Lys Thr
            20                  25                  30          
Ala Gly Asn Ser Glu Phe Leu Gly Lys Thr Pro Gly Gln Asn Ala Gln
        35                  40                  45              
Lys Trp Ile Pro Ala Arg Ser Thr Arg Arg Asp Asp Asn Ser Ala Ala
    50                  55                  60                  
Asn Asn Ser Ala Asn Glu Lys Glu Arg His Asp Ala Ile Phe Arg Lys
65                  70                  75                  80  
Val Arg Gly Ile Leu Asn Lys Leu Thr Pro Glu Lys Phe Asp Lys Leu
                85                  90                  95      
Cys Leu Glu Leu Leu Asn Val Gly Val Glu Ser Lys Leu Ile Leu Lys
            100                 105                 110         
Gly Val Ile Leu Leu Ile Val Asp Lys Ala Leu Glu Glu Pro Lys Tyr
        115                 120                 125             
Ser Ser Leu Tyr Ala Gln Leu Cys Leu Arg Leu Ala Glu Asp Ala Pro
    130                 135                 140                 
Asn Phe Asp Gly Pro Ala Ala Glu Gly Gln Pro Gly Gln Lys Gln Ser
145                 150                 155                 160 
Thr Thr Phe Arg Arg Leu Leu Ile Ser Lys Leu Gln Asp Glu Phe Glu
                165                 170                 175     
Asn Arg Thr Arg Asn Val Asp Val Tyr Asp Lys Arg Glu Asn Pro Leu
            180                 185                 190         
Leu Pro Glu Glu Glu Glu Gln Arg Ala Ile Ala Lys Ile Lys Met Leu
        195                 200                 205             
Gly Asn Ile Lys Phe Ile Gly Glu Leu Gly Lys Leu Asp Leu Ile His
    210                 215                 220                 
Glu Ser Ile Leu His Lys Cys Ile Lys Thr Leu Leu Glu Lys Lys Lys
225                 230                 235                 240 
Arg Val Gln Leu Lys Asp Met Gly Glu Asp Leu Glu Cys Leu Cys Gln
                245                 250                 255     
Ile Met Arg Thr Val Gly Pro Arg Leu Asp His Glu Arg Ala Lys Ser
            260                 265                 270         
Leu Met Asp Gln Tyr Phe Ala Arg Met Cys Ser Leu Met Leu Ser Lys
        275                 280                 285             
Glu Leu Pro Ala Arg Ile Arg Phe Leu Leu Gln Asp Thr Val Glu Leu
    290                 295                 300                 
Arg Glu His His Trp Val Pro Arg Lys Ala Phe Leu Asp Asn Gly Pro
305                 310                 315                 320 
Lys Thr Ile Asn Gln Ile Arg Gln Asp Ala Val Lys Asp Leu Gly Val
                325                 330                 335     
Phe Ile Pro Ala Pro Met Ala Gln Gly Met Arg Ser Asp Phe Phe Leu
            340                 345                 350         
Glu Gly Pro Phe Met Pro Pro Arg Met Lys Met Asp Arg Asp Pro Leu
        355                 360                 365             
Gly Gly Leu Ala Asp Met Phe Gly Gln Met Pro Gly Ser Gly Ile Gly
    370                 375                 380                 
Thr Gly Pro Gly Val Ile Gln Asp Arg Phe Ser Pro Thr Met Gly Arg
385                 390                 395                 400 
His Arg Ser Asn Gln Leu Phe Asn Gly His Gly Gly His Ile Met Pro
                405                 410                 415     
Pro Thr Gln Ser Gln Phe Gly Glu Met Gly Gly Lys Phe Met Lys Ser
            420                 425                 430         
Gln Gly Leu Ser Gln Leu Tyr His Asn Gln Ser Gln Gly Leu Leu Ser
        435                 440                 445             
Gln Leu Gln Gly Gln Ser Lys Asp Met Pro Pro Arg Phe Ser Lys Lys
    450                 455                 460                 
Gly Gln Leu Asn Ala Asp Glu Ile Ser Leu Arg Pro Ala Gln Ser Phe
465                 470                 475                 480 
Leu Met Asn Lys Asn Gln Val Pro Lys Leu Gln Pro Gln Ile Thr Met
                485                 490                 495     
Ile Pro Pro Ser Ala Gln Pro Pro Arg Thr Gln Thr Pro Pro Leu Gly
            500                 505                 510         
Gln Thr Pro Gln Leu Gly Leu Lys Thr Asn Pro Pro Leu Ile Gln Glu
        515                 520                 525             
Lys Pro Ala Lys Thr Ser Lys Lys Pro Pro Pro Ser Lys Glu Glu Leu
    530                 535                 540                 
Leu Lys Leu Thr Glu Thr Val Val Thr Glu Tyr Leu Asn Ser Gly Asn
545                 550                 555                 560 
Ala Asn Glu Ala Val Asn Gly Val Arg Glu Met Arg Ala Pro Lys His
                565                 570                 575     
Phe Leu Pro Glu Met Leu Ser Lys Val Ile Ile Leu Ser Leu Asp Arg
            580                 585                 590         
Ser Asp Glu Asp Lys Glu Lys Ala Ser Ser Leu Ile Ser Leu Leu Lys
        595                 600                 605             
Gln Glu Gly Ile Ala Thr Ser Asp Asn Phe Met Gln Ala Phe Leu Asn
    610                 615                 620                 
Val Leu Asp Gln Cys Pro Lys Leu Glu Val Asp Ile Pro Leu Val Lys
625                 630                 635                 640 
Ser Tyr Leu Ala Gln Phe Ala Ala Arg Ala Ile Ile Ser Glu Leu Val
                645                 650                 655     
Ser Ile Ser Glu Leu Ala Gln Pro Leu Glu Ser Gly Thr His Phe Pro
            660                 665                 670         
Leu Phe Leu Leu Cys Leu Gln Gln Leu Ala Lys Leu Gln Asp Arg Glu
        675                 680                 685             
Trp Leu Thr Glu Leu Phe Gln Gln Ser Lys Val Asn Met Gln Lys Met
    690                 695                 700                 
Leu Pro Glu Ile Asp Gln Asn Lys Asp Arg Met Leu Glu Ile Leu Glu
705                 710                 715                 720 
Gly Lys Gly Leu Ser Phe Leu Phe Pro Leu Leu Lys Leu Glu Lys Glu
                725                 730                 735     
Leu Leu Lys Gln Ile Lys Leu Asp Pro Ser Pro Gln Thr Ile Tyr Lys
            740                 745                 750         
Trp Ile Lys Asp Asn Ile Ser Pro Lys Leu His Val Asp Lys Gly Phe
        755                 760                 765             
Val Asn Ile Leu Met Thr Ser Phe Leu Gln Tyr Ile Ser Ser Glu Val
    770                 775                 780                 
Asn Pro Pro Ser Asp Glu Thr Asp Ser Ser Ser Ala Pro Ser Lys Glu
785                 790                 795                 800 
Gln Leu Glu Gln Glu Lys Gln Leu Leu Leu Ser Phe Lys Pro Val Met
                805                 810                 815     
Gln Lys Phe Leu His Asp His Val Asp Leu Gln Val Ser Ala Leu Tyr
            820                 825                 830         
Ala Leu Gln Val His Cys Tyr Asn Ser Asn Phe Pro Lys Gly Met Leu
        835                 840                 845             
Leu Arg Phe Phe Val His Phe Tyr Asp Met Glu Ile Ile Glu Glu Glu
    850                 855                 860                 
Ala Phe Leu Ala Trp Lys Glu Asp Ile Thr Gln Glu Phe Pro Gly Lys
865                 870                 875                 880 
Gly Lys Ala Leu Phe Gln Val Asn Gln Trp Leu Thr Trp Leu Glu Thr
                885                 890                 895     
Ala Glu Glu Glu Glu Ser Glu Glu Glu Ala Asp
            900                 905         


<210> 6889
<211> 518
<212> PRT
<213> Homo sapiens

<400> 6889
Met Thr Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro
 1               5                  10                  15      
Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Thr Pro Asn
            20                  25                  30          
Leu Glu Ile Lys Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp Gln Asn
        35                  40                  45              
Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala Thr Gly Glu
    50                  55                  60                  
Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala
65                  70                  75                  80  
Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg
                85                  90                  95      
Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu
            100                 105                 110         
Val Glu Arg Asp Arg Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly
        115                 120                 125             
Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile
    130                 135                 140                 
Lys Thr Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met
145                 150                 155                 160 
Thr Ile Pro Val Asp Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro
                165                 170                 175     
Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met
            180                 185                 190         
Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val
        195                 200                 205             
Ile Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala
    210                 215                 220                 
Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro
225                 230                 235                 240 
Gly Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile
                245                 250                 255     
Asp Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Gln
            260                 265                 270         
Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly
        275                 280                 285             
Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala
    290                 295                 300                 
Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys
305                 310                 315                 320 
Thr Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe
                325                 330                 335     
Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro
            340                 345                 350         
Phe Asp Pro Thr Thr Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr
        355                 360                 365             
Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys
    370                 375                 380                 
Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu
385                 390                 395                 400 
Pro Thr Val Phe Ser Asn Val Thr Asp Asp Met Arg Ile Ala Lys Glu
                405                 410                 415     
Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys Thr Met Asp
            420                 425                 430         
Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala
        435                 440                 445             
Val Phe Thr Asn Asp Ile Asn Lys Ala Leu Thr Val Ser Ser Ala Met
    450                 455                 460                 
Gln Ala Gly Thr Val Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln
465                 470                 475                 480 
Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly
                485                 490                 495     
Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Thr Val Thr Val Lys
            500                 505                 510         
Ile Pro Gln Lys Asn Ser
        515             


<210> 6890
<211> 422
<212> PRT
<213> Homo sapiens

<400> 6890
Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu
 1               5                  10                  15      
Val Glu Arg Asp Arg Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly
            20                  25                  30          
Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile
        35                  40                  45              
Lys Thr Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met
    50                  55                  60                  
Thr Ile Pro Val Asp Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro
65                  70                  75                  80  
Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met
                85                  90                  95      
Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val
            100                 105                 110         
Ile Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala
        115                 120                 125             
Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro
    130                 135                 140                 
Gly Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile
145                 150                 155                 160 
Asp Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Gln
                165                 170                 175     
Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly
            180                 185                 190         
Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala
        195                 200                 205             
Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys
    210                 215                 220                 
Thr Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe
225                 230                 235                 240 
Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Ile Val Gly Ser Pro
                245                 250                 255     
Phe Asp Pro Thr Thr Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr
            260                 265                 270         
Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys
        275                 280                 285             
Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu
    290                 295                 300                 
Pro Thr Val Phe Ser Asn Val Thr Asp Asp Met Arg Ile Ala Lys Glu
305                 310                 315                 320 
Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys Thr Met Asp
                325                 330                 335     
Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala
            340                 345                 350         
Val Phe Thr Asn Asp Ile Asn Lys Ala Leu Thr Val Ser Ser Ala Met
        355                 360                 365             
Gln Ala Gly Thr Val Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln
    370                 375                 380                 
Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly
385                 390                 395                 400 
Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Thr Val Thr Val Lys
                405                 410                 415     
Ile Pro Gln Lys Asn Ser
            420         


<210> 6891
<211> 480
<212> PRT
<213> Homo sapiens

<400> 6891
Met Thr Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro
 1               5                  10                  15      
Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Thr Pro Asn
            20                  25                  30          
Leu Glu Ile Lys Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp Gln Asn
        35                  40                  45              
Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala Thr Gly Glu
    50                  55                  60                  
Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala
65                  70                  75                  80  
Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg
                85                  90                  95      
Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu
            100                 105                 110         
Val Glu Arg Asp Arg Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly
        115                 120                 125             
Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile
    130                 135                 140                 
Lys Thr Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met
145                 150                 155                 160 
Thr Ile Pro Val Asp Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro
                165                 170                 175     
Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met
            180                 185                 190         
Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val
        195                 200                 205             
Ile Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala
    210                 215                 220                 
Leu Ile Lys Glu Val Gly Lys Leu Ile Gln Glu Ala Ala Gly Arg Ser
225                 230                 235                 240 
Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile
                245                 250                 255     
Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala Val Glu Gln Ala His Gln
            260                 265                 270         
Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Thr Ala Gly Ser Arg Ile
        275                 280                 285             
Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe Val Arg Arg Ser Val Glu
    290                 295                 300                 
Arg Ala Lys Arg Arg Val Val Gly Ser Pro Phe Asp Pro Thr Thr Glu
305                 310                 315                 320 
Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr Asn Lys Ile Leu Glu Leu
                325                 330                 335     
Ile Gln Ser Gly Val Ala Glu Gly Ala Lys Leu Glu Cys Gly Gly Lys
            340                 345                 350         
Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu Pro Thr Val Phe Ser Asn
        355                 360                 365             
Val Thr Asp Asp Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro Val
    370                 375                 380                 
Gln Glu Ile Leu Arg Phe Lys Thr Met Asp Glu Val Ile Glu Arg Ala
385                 390                 395                 400 
Asn Asn Ser Asp Phe Gly Leu Val Ala Ala Val Phe Thr Asn Asp Ile
                405                 410                 415     
Asn Lys Ala Leu Thr Val Ser Ser Ala Met Gln Ala Gly Thr Val Trp
            420                 425                 430         
Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln Ser Pro Phe Gly Gly Phe
        435                 440                 445             
Lys Met Ser Gly Asn Gly Arg Glu Met Gly Glu Phe Gly Leu Arg Glu
    450                 455                 460                 
Tyr Ser Glu Val Lys Thr Val Thr Val Lys Ile Pro Gln Lys Asn Ser
465                 470                 475                 480 


<210> 6892
<211> 1833
<212> PRT
<213> Homo sapiens

<400> 6892
Met Ile Thr Met Thr Leu Gln Ser Val Pro Asp Val Pro Val Lys Glu
 1               5                  10                  15      
Asp Thr Asn Ser Val Val Glu Lys Ala Met Asp Glu Ile Lys Ser Gln
            20                  25                  30          
Glu Leu Asn Leu Glu Gly Gln Arg Lys Ile Ser Pro Gly Ser Ile Lys
        35                  40                  45              
Asp Ser Lys Thr Glu Ala Ser Gly Asn Ile Ala Ile Arg Lys Ser Ala
    50                  55                  60                  
Lys Val Ile Phe Ala Leu Asp Glu Thr Glu Leu Lys Ser Lys Pro Glu
65                  70                  75                  80  
His Thr Trp Lys Lys Asn Leu Phe Glu Arg Met Glu Ala Arg Ala Gln
                85                  90                  95      
Ala Met Gln Gln Lys Ile Ile Asp Lys Glu Asn Leu Lys Lys Glu Leu
            100                 105                 110         
Glu Lys Lys Ala Glu Lys Lys Leu Pro Arg Asp Asn Leu Ala Lys Glu
        115                 120                 125             
Trp Phe Asn Thr Asp Ser Met Thr Leu Asn Asn Thr Ala Tyr Leu Leu
    130                 135                 140                 
Asp Lys Leu Leu Pro Thr Leu Val Pro Gly Val Glu Asn Met Leu Thr
145                 150                 155                 160 
Gln Val Glu Lys Lys Lys Val Leu Thr Glu Ala Asp Thr Pro Ser Lys
                165                 170                 175     
Phe Asp Pro Ile Asn Tyr Leu Gly Glu Tyr Leu Ile Arg Asn Asn Pro
            180                 185                 190         
Asn Tyr Ile Lys Asp Pro Gly Met Ser Gly Tyr Gln Arg Leu Met Lys
        195                 200                 205             
Glu Val Thr Glu Asp Leu Lys Ile Tyr Val Pro Asp Thr Ile Cys Asn
    210                 215                 220                 
Ser Tyr Val Ser Ser Arg Pro Val Asp Gly His Gly Leu Gly Arg Val
225                 230                 235                 240 
Gln Cys Asp Pro Cys Leu Glu Gly His Asp Arg Tyr Pro Asp Arg Val
                245                 250                 255     
Glu Ala Asp Ser Val Thr Ile Trp Gly Asp Phe Ser Asp Val His Ile
            260                 265                 270         
Ser Arg Asn Ile Ile His Thr Ser Tyr Ser Gly Asn Pro Ser Pro His
        275                 280                 285             
Ser Tyr Lys Ser Leu Pro Asn His Phe Pro Val Tyr Ile Leu Pro Tyr
    290                 295                 300                 
Pro Thr Leu Glu Asp Phe Glu Pro Gln Thr Leu Cys Ala Phe Leu Tyr
305                 310                 315                 320 
Leu Ser Gln His Lys Ile Gly Pro Asn Pro Phe Cys Thr Lys Leu Pro
                325                 330                 335     
Asp Asn Leu Trp Gly Val Phe Lys Ser Gly Val Ser Lys Met Lys Glu
            340                 345                 350         
Asn Val Lys Gln Asn Arg Lys Gln Arg Glu Ser Ile Asp Lys Ile Ile
        355                 360                 365             
Val Lys Val Ala Asn Thr Arg Lys Gln Ala Leu Gln Glu Gln Phe Asp
    370                 375                 380                 
Glu Trp Ile Leu Asp Pro Lys Gly Met Ile Pro Lys Ser Val Tyr Ile
385                 390                 395                 400 
Ser Ser His Ile Lys Asp Leu Lys Ser Glu Met Phe Glu Glu Leu Leu
                405                 410                 415     
Lys His Leu Cys His Ser Ala Asp Glu Phe Arg Glu Val Ile Lys Ala
            420                 425                 430         
Asp Met Arg Arg Gln Met Phe Ala Glu Leu Phe Leu His Cys Asp His
        435                 440                 445             
Gly Lys Val Gly Phe Leu Asp Arg Gln Arg Thr Leu Ala Leu Leu Glu
    450                 455                 460                 
Leu Phe Tyr Asp His Ser Ser Gln Met Leu Arg Ser Leu Leu Arg Asn
465                 470                 475                 480 
Pro Arg Gln Trp Pro Phe Ile Glu Phe Glu Glu Ile Asn Leu Thr Glu
                485                 490                 495     
Leu Trp Gly Asp Met Asp Asn Gln Lys His Ile Tyr Glu Gly Phe Asp
            500                 505                 510         
Lys Val Leu Leu Glu Met Asn Thr Leu Leu Ser Ala Asn His Ala Ser
        515                 520                 525             
Lys Thr Gln Ser Lys Leu Leu Glu Ser Pro Asp Gln Pro Lys Leu Asn
    530                 535                 540                 
Glu Gln Arg Thr Ser Thr Pro Ser Pro Asn Pro Pro Glu Gln Gln Arg
545                 550                 555                 560 
Gly Val Thr Ala Glu Gln Gly Pro Gln Arg Ile Ser Ile Glu Glu Gln
                565                 570                 575     
Gln Gln Gly Lys Lys Pro Thr Ala Glu Gln Glu Leu Tyr Ile Glu Ser
            580                 585                 590         
Val Ile Glu Pro Gly Thr His Thr Glu Ser Thr Leu Glu Gln Gly Ser
        595                 600                 605             
Ser Arg Arg Leu Leu Thr Glu Gln Glu Thr His Arg Glu Ser Thr Thr
    610                 615                 620                 
Glu Gln Gly Gln His Lys Gly Ser Ile Glu Gly Gln Gly Pro Arg Arg
625                 630                 635                 640 
Val Ser Val Ser Glu Gln Gly Ser Ser Arg Glu Ser Val Ala Glu Gln
                645                 650                 655     
Gly Ser Arg Arg Glu Ser Ile Ala Glu Gln Asp Arg His Lys Gly Ser
            660                 665                 670         
Val Ala Glu Gln Gly Ser Arg Arg Met Ser Ala Ala Glu Gln Gly Ser
        675                 680                 685             
Leu Arg Glu Ser Val Ile Glu Glu Pro Tyr Gln Lys Ser Glu Gln Gly
    690                 695                 700                 
Pro Tyr Gly Glu Ile Ile Ser Glu Glu Gln Glu Asp Ile Gly Ser Thr
705                 710                 715                 720 
Ser Gln Ser Arg Lys Asp Ser Ile Leu Lys Ser Thr Lys Tyr Gly Glu
                725                 730                 735     
Pro Ile Thr Ser Glu Tyr Ile Glu Val Pro Leu Gln Glu Lys Arg Ser
            740                 745                 750         
Trp Glu Gln Thr Tyr Glu Glu Glu Ile Phe Leu Ser Ser Glu Leu Gln
        755                 760                 765             
Glu Glu Val Pro Thr Leu Ser Arg Lys Asp His Phe Pro Glu Thr Thr
    770                 775                 780                 
Lys Lys Glu Val Gln Lys Asp Lys Pro Cys Glu Pro Lys Ser Gln Lys
785                 790                 795                 800 
Ile Glu Gly Lys Ser Trp Ser Gly Glu Phe Phe Thr Cys Asn Trp Lys
                805                 810                 815     
Met Lys Tyr Val Thr Phe Glu Asp Glu Glu Gln Ala Asn Leu Ile Tyr
            820                 825                 830         
Gly Asn Ser Arg Phe Thr Asp Leu His Ser Ile Ile Arg Asn Ile Gln
        835                 840                 845             
Ser Cys Lys Glu Val Lys Gly Arg Thr Ala Phe Asn Gly Val Ser Phe
    850                 855                 860                 
Asn Leu Leu Gln Phe Val Gln Leu Leu Glu Thr Phe Val Gly Glu Asp
865                 870                 875                 880 
Ala Pro Leu Ser Val Ser Glu Thr Leu Thr Ser Phe Phe Lys Glu Gly
                885                 890                 895     
Tyr Val Glu Thr Glu Gln Glu Lys Met Asn Ala Leu Glu Gln Phe Ser
            900                 905                 910         
Gln Asn Ala Phe Gln Val Arg Gln Arg Leu Leu Leu Glu Ala Ile Phe
        915                 920                 925             
Gln Lys Trp Asp Ser Asp Gly Ser Gly Phe Leu Asp Leu Lys Glu Val
    930                 935                 940                 
Asp Glu Leu Leu Tyr Thr Tyr Lys Glu Gly Met Glu Lys Glu Ser Met
945                 950                 955                 960 
Lys Lys Ala Ala Asp Met Gly Arg Ser Leu Val Gly Leu Pro Val Arg
                965                 970                 975     
Val Ala Arg Ala Val Asp Ile Thr Leu Leu Phe Arg Ala Ser Val Lys
            980                 985                 990         
Thr Val Lys Thr Gln Asn Lys Ala Leu Gly Val Ala Val Gly Gly Arg
        995                 1000                1005            
Val Asp Gly Ser Arg Asp Glu Leu Phe Arg Arg Ser Pro Trp Pro Lys
    1010                1015                1020                
Gly Asn Phe Ser Ser Arg Ala Arg Glu Met Ile Ser His Ser Gly Lys
1025                1030                1035                1040
Leu Arg Asp Phe Leu Leu Glu His Arg Lys Asp Tyr Ile Asn Ala Tyr
                1045                1050                1055    
Ser His Thr Met Ser Glu Tyr Gly Arg Met Thr Asp Thr Glu Arg Asp
            1060                1065                1070        
Gln Ile Asp Gln Asp Val Gln Ile Phe Met Arg Thr Cys Ser Glu Ala
        1075                1080                1085            
Ile Gln Gln Leu Arg Thr Glu Ala His Lys Glu Ile His Ser Gln Gln
    1090                1095                1100                
Val Lys Glu His Arg Thr Ala Val Leu Asp Phe Ile Glu Asp Tyr Leu
1105                1110                1115                1120
Lys Lys Val Cys Lys Leu Tyr Ser Glu Gln Arg Ala Ile Arg Val Lys
                1125                1130                1135    
Arg Val Thr Glu Glu Asn Pro Ala Thr Glu Glu His Pro Glu Lys Ile
            1140                1145                1150        
Leu Thr Glu Arg Gln Pro Glu Leu Gly Thr Trp Gly Asp Gly Lys Gly
        1155                1160                1165            
Glu Asp Glu Leu Ser Pro Glu Glu Ile Gln Met Phe Glu Gln Glu Asn
    1170                1175                1180                
Gln Arg Leu Ile Gly Glu Met Asn Ser Leu Phe Asp Glu Val Arg Gln
1185                1190                1195                1200
Ile Lys Gly Arg Val Val Glu Ile Ser Arg Leu Gln Glu Ile Phe Thr
                1205                1210                1215    
Glu Lys Val Leu Gln Gln Glu Ala Glu Ile Asp Gly Val His Gln Leu
            1220                1225                1230        
Val Val Gly Ala Thr Glu Asn Ile Lys Glu Gly Asn Glu Asp Ile Arg
        1235                1240                1245            
Glu Ala Ile Lys Asn Asn Ala Gly Phe Arg Val Trp Ile Leu Phe Phe
    1250                1255                1260                
Leu Val Met Cys Ser Phe Ser Leu Leu Phe Leu Asp Trp Gly Asn Glu
1265                1270                1275                1280
Asp Gln Val Leu Glu Ser Val Val Glu Phe Leu Met Asn Ala Leu Glu
                1285                1290                1295    
Arg Ser His Ile Glu Ser Leu Arg Asn Ser Ala Arg Arg Lys Trp Leu
            1300                1305                1310        
His Gln Ile Gln Cys Ala Ala Glu Thr Ser Gly Val Ser Leu Glu Pro
        1315                1320                1325            
Val Tyr Ser Glu Thr Phe Lys Ala Leu Met Gln Asp Ala Glu Ala His
    1330                1335                1340                
Gly Asn Lys Lys Ile Ser Ala His Ile Ser Leu Leu Glu Glu Asn Leu
1345                1350                1355                1360
Leu Leu Pro Glu Lys Gly Asn Val Leu Leu Arg Asn Val Ala Cys Thr
                1365                1370                1375    
Leu Asp Asp Ala Gln Phe Val Leu Asn Arg Val Leu Tyr Arg Asp Met
            1380                1385                1390        
Lys Gly Ile Ser Phe Thr Val Val Asp Glu Gly Lys Pro Ile His Val
        1395                1400                1405            
Pro Gln Val Gln Tyr His Gly Asn Ile Phe Phe Trp Asn Gln Ser Arg
    1410                1415                1420                
Asn Lys His Asp Tyr Asn Gly Ser Phe Leu Ala Leu Pro Leu Gln Asp
1425                1430                1435                1440
Ala Tyr Met Arg Ile Phe Gly Val Leu Ala Val Asp Thr Leu Arg Asp
                1445                1450                1455    
Pro His Glu Ile Asn Ile Phe Leu Pro His Glu Ile Arg Phe Tyr Gln
            1460                1465                1470        
Gly Val Ala Asn Val Phe Ser Thr Ala Tyr His Tyr Val His Ser Arg
        1475                1480                1485            
Glu His Ile Leu His Ile Val Ile Thr Gly Ile Gly Trp Leu Tyr Asp
    1490                1495                1500                
Val Thr Ser Ser Ile Thr Ser Ile Thr Thr Tyr Phe Val Glu Pro Ser
1505                1510                1515                1520
Pro Ala Gln Asp Ser Asp Tyr Val Leu Arg Asn Met Met Val Thr Gly
                1525                1530                1535    
Gln Leu Gly Leu Thr Glu Ile His Lys Asn Pro Pro Thr Ile His Arg
            1540                1545                1550        
Lys Ser Cys Ile Phe Arg Asp Phe Leu Phe Lys Cys Thr Asp Ser Ser
        1555                1560                1565            
Glu Val Val Leu Ala Ser Ala Cys Gly Glu Thr His Ile Val Val Pro
    1570                1575                1580                
Leu Arg Glu Arg Thr Gly Glu Ala Leu Gly Val Leu Asp Phe Asn Ile
1585                1590                1595                1600
Gly Gln Asn Arg Met Leu Leu Cys Gln Glu Tyr Lys Asp Leu Gln Lys
                1605                1610                1615    
Met Met Lys Val Val Gln Val Ala Cys Tyr Glu Ile Leu Gly Glu Phe
            1620                1625                1630        
Ser Gly Glu Ile Lys Lys Lys Tyr Ile Leu Glu Ile Glu Asn Val Arg
        1635                1640                1645            
Glu Val Gln Arg Ala Gly Ile Leu Phe Phe Arg Ile Met Leu Leu Glu
    1650                1655                1660                
Leu Gln Glu Ser Ile Gln Leu Leu Asn Ser Met Glu Phe Val Ser Leu
1665                1670                1675                1680
Leu Leu Tyr Asp His Thr Leu Val Thr Glu Pro Asn Ser Pro Gln Asp
                1685                1690                1695    
Ser Lys Ser Met Glu Leu Glu Ala Asn Val Lys Leu Val Arg Asp Ile
            1700                1705                1710        
Leu Lys Ala Val Ile Leu Phe Phe His Pro Glu Leu Glu Phe Ser Ser
        1715                1720                1725            
Asp Phe Gly Ser Trp Asp Lys Cys Lys Phe Tyr Val Asn Lys Tyr Leu
    1730                1735                1740                
Val Asn Asn Ile Cys Ala Phe Asp Pro Thr Ala Lys His Val Glu Val
1745                1750                1755                1760
Asn Val Gln Leu Ile Asp Glu Tyr Ile Arg Asp His Ser Arg Thr Glu
                1765                1770                1775    
Val Trp Lys Phe Gly Asn Val Val Ile Glu His Leu Tyr His Trp Ile
            1780                1785                1790        
His Ile Cys Ser Ala Leu Met Lys Ile Thr Lys Gln Leu Asn Ser Gly
        1795                1800                1805            
Ile Thr Pro Pro Leu Pro Ser Lys Thr Asp Asn Tyr Met Tyr Ala Lys
    1810                1815                1820                
Met Pro Gly Glu Gly Leu Gln Glu Lys
1825                1830            


<210> 6893
<211> 346
<212> PRT
<213> Homo sapiens

<400> 6893
Met Glu Thr Gln Leu Ser Asn Gly Pro Thr Cys Asn Asn Thr Ala Asn
 1               5                  10                  15      
Gly Pro Thr Thr Ile Asn Asn Asn Cys Ser Ser Pro Val Asp Ser Gly
            20                  25                  30          
Asn Thr Glu Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln
        35                  40                  45              
Asn Met Thr Gln Glu Glu Leu Lys Ser Leu Phe Gly Ser Ile Gly Glu
    50                  55                  60                  
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu
65                  70                  75                  80  
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala
                85                  90                  95      
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val
            100                 105                 110         
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr
        115                 120                 125             
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu
    130                 135                 140                 
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln
145                 150                 155                 160 
Val Thr Gly Ile Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg
                165                 170                 175     
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Pro
            180                 185                 190         
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln
        195                 200                 205             
Lys Thr Asn Gln Ala Ile Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg
    210                 215                 220                 
Arg Tyr Pro Gly Pro Leu Ala Gln Gln Ala Gln Arg Phe Arg Phe Ser
225                 230                 235                 240 
Pro Met Thr Ile Asp Gly Met Thr Ser Leu Ala Gly Ile Asn Ile Pro
                245                 250                 255     
Gly His Pro Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu Ala Pro
            260                 265                 270         
Asp Ala Asp Glu Ser Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala
        275                 280                 285             
Val Thr Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys
    290                 295                 300                 
Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala
305                 310                 315                 320 
Ile Arg Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val
                325                 330                 335     
Ser Phe Lys Thr Asn Lys Thr His Lys Ala
            340                 345     


<210> 6894
<211> 359
<212> PRT
<213> Homo sapiens

<400> 6894
Met Glu Thr Gln Leu Ser Asn Gly Pro Thr Cys Asn Asn Thr Ala Asn
 1               5                  10                  15      
Gly Pro Thr Thr Ile Asn Asn Asn Cys Ser Ser Pro Val Asp Ser Gly
            20                  25                  30          
Asn Thr Glu Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln
        35                  40                  45              
Asn Met Thr Gln Glu Glu Leu Lys Ser Leu Phe Gly Ser Ile Gly Glu
    50                  55                  60                  
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu
65                  70                  75                  80  
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala
                85                  90                  95      
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val
            100                 105                 110         
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr
        115                 120                 125             
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu
    130                 135                 140                 
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln
145                 150                 155                 160 
Val Thr Gly Ile Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg
                165                 170                 175     
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Pro
            180                 185                 190         
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln
        195                 200                 205             
Lys Thr Asn Gln Ala Ile Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg
    210                 215                 220                 
Arg Tyr Pro Gly Pro Leu Ala Gln Gln Ala Gln Arg Phe Arg Leu Asp
225                 230                 235                 240 
Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Arg Phe Ser Pro Met Thr
                245                 250                 255     
Ile Asp Gly Met Thr Ser Leu Ala Gly Ile Asn Ile Pro Gly His Pro
            260                 265                 270         
Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu Ala Pro Asp Ala Asp
        275                 280                 285             
Glu Ser Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala Val Thr Asn
    290                 295                 300                 
Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly
305                 310                 315                 320 
Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Arg Ser
                325                 330                 335     
Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys
            340                 345                 350         
Thr Asn Lys Thr His Lys Ala
        355                 


<210> 6895
<211> 346
<212> PRT
<213> Homo sapiens

<400> 6895
Met Glu Thr Gln Leu Ser Asn Gly Pro Thr Cys Asn Asn Thr Ala Asn
 1               5                  10                  15      
Gly Pro Thr Thr Ile Asn Asn Asn Cys Ser Ser Pro Val Asp Ser Gly
            20                  25                  30          
Asn Thr Glu Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln
        35                  40                  45              
Asn Met Thr Gln Glu Glu Leu Lys Ser Leu Phe Gly Ser Ile Gly Glu
    50                  55                  60                  
Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu
65                  70                  75                  80  
Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala
                85                  90                  95      
Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val
            100                 105                 110         
Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr
        115                 120                 125             
Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu
    130                 135                 140                 
Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln
145                 150                 155                 160 
Val Thr Gly Ile Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg
                165                 170                 175     
Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Pro
            180                 185                 190         
Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln
        195                 200                 205             
Lys Thr Asn Gln Ala Ile Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg
    210                 215                 220                 
Arg Tyr Pro Gly Pro Leu Ala Gln Gln Ala Gln Arg Phe Arg Phe Ser
225                 230                 235                 240 
Pro Met Thr Ile Asp Gly Met Thr Ser Leu Ala Gly Ile Asn Ile Pro
                245                 250                 255     
Gly His Pro Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu Ala Pro
            260                 265                 270         
Asp Ala Asp Glu Ser Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala
        275                 280                 285             
Val Thr Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys
    290                 295                 300                 
Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala
305                 310                 315                 320 
Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val
                325                 330                 335     
Ser Phe Lys Thr Asn Lys Thr His Lys Ala
            340                 345     


<210> 6896
<211> 339
<212> PRT
<213> Homo sapiens

<400> 6896
Met Ala Ala Glu Asp Glu Leu Gln Leu Pro Arg Leu Pro Glu Leu Phe
 1               5                  10                  15      
Glu Thr Gly Arg Gln Leu Leu Asp Glu Val Glu Val Ala Thr Glu Pro
            20                  25                  30          
Ala Gly Ser Arg Ile Val Gln Glu Lys Val Phe Lys Gly Leu Asp Leu
        35                  40                  45              
Leu Glu Lys Ala Ala Glu Met Leu Ser Gln Leu Asp Leu Phe Ser Arg
    50                  55                  60                  
Asn Glu Asp Leu Glu Glu Ile Ala Ser Thr Asp Leu Lys Tyr Leu Leu
65                  70                  75                  80  
Val Pro Ala Phe Gln Gly Ala Leu Thr Met Lys Gln Val Asn Pro Ser
                85                  90                  95      
Lys Arg Leu Asp His Leu Gln Arg Ala Arg Glu His Phe Ile Asn Tyr
            100                 105                 110         
Leu Thr Gln Cys His Cys Tyr His Val Ala Glu Phe Glu Leu Pro Lys
        115                 120                 125             
Thr Met Asn Asn Ser Ala Glu Asn His Thr Ala Asn Ser Ser Met Ala
    130                 135                 140                 
Tyr Pro Ser Leu Val Ala Met Ala Ser Gln Arg Gln Ala Lys Ile Gln
145                 150                 155                 160 
Arg Tyr Lys Gln Lys Lys Glu Leu Glu His Arg Leu Ser Ala Met Lys
                165                 170                 175     
Ser Ala Val Glu Ser Gly Gln Ala Asp Asp Glu Arg Val Arg Glu Tyr
            180                 185                 190         
Tyr Leu Leu His Leu Gln Arg Trp Ile Asp Ile Ser Leu Glu Glu Ile
        195                 200                 205             
Glu Ser Ile Asp Gln Glu Ile Lys Ile Leu Arg Glu Arg Asp Ser Ser
    210                 215                 220                 
Arg Glu Ala Ser Thr Ser Asn Ser Ser Arg Gln Glu Arg Pro Pro Val
225                 230                 235                 240 
Lys Pro Phe Ile Leu Thr Arg Asn Met Ala Gln Ala Lys Val Phe Gly
                245                 250                 255     
Ala Gly Tyr Pro Ser Leu Pro Thr Met Thr Val Ser Asp Trp Tyr Glu
            260                 265                 270         
Gln His Arg Lys Tyr Gly Ala Leu Pro Asp Gln Gly Ile Ala Lys Ala
        275                 280                 285             
Ala Pro Glu Glu Phe Arg Lys Ala Ala Gln Gln Gln Glu Glu Gln Glu
    290                 295                 300                 
Glu Lys Glu Glu Glu Asp Asp Glu Gln Thr Leu His Arg Ala Arg Glu
305                 310                 315                 320 
Trp Asp Asp Trp Lys Asp Thr His Pro Arg Gly Tyr Gly Asn Arg Gln
                325                 330                 335     
Asn Met Gly
            


<210> 6897
<211> 714
<212> PRT
<213> Homo sapiens

<400> 6897
Met Ser Glu Glu Ile Ile Thr Pro Val Tyr Cys Thr Gly Val Ser Ala
 1               5                  10                  15      
Gln Val Gln Lys Gln Arg Ala Arg Glu Leu Gly Leu Gly Arg His Glu
            20                  25                  30          
Asn Ala Ile Lys Tyr Leu Gly Gln Asp Tyr Glu Gln Leu Arg Val Arg
        35                  40                  45              
Cys Leu Gln Ser Gly Thr Leu Phe Arg Asp Glu Ala Phe Pro Pro Val
    50                  55                  60                  
Pro Gln Ser Leu Gly Tyr Lys Asp Leu Gly Pro Asn Ser Ser Lys Thr
65                  70                  75                  80  
Tyr Gly Ile Lys Trp Lys Arg Pro Thr Glu Leu Leu Ser Asn Pro Gln
                85                  90                  95      
Phe Ile Val Asp Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Ala Leu
            100                 105                 110         
Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Asp
        115                 120                 125             
Thr Leu Leu His Arg Val Val Pro His Gly Gln Ser Phe Gln Asn Gly
    130                 135                 140                 
Tyr Ala Gly Ile Phe His Phe Gln Leu Trp Gln Phe Gly Glu Trp Val
145                 150                 155                 160 
Asp Val Val Val Asp Asp Leu Leu Pro Ile Lys Asp Gly Lys Leu Val
                165                 170                 175     
Phe Val His Ser Ala Glu Gly Asn Glu Phe Trp Ser Ala Leu Leu Glu
            180                 185                 190         
Lys Ala Tyr Ala Lys Val Asn Gly Ser Tyr Glu Ala Leu Ser Gly Gly
        195                 200                 205             
Ser Thr Ser Glu Gly Phe Glu Asp Phe Thr Gly Gly Val Thr Glu Trp
    210                 215                 220                 
Tyr Glu Leu Arg Lys Ala Pro Ser Asp Leu Tyr Gln Ile Ile Leu Lys
225                 230                 235                 240 
Ala Leu Glu Arg Gly Ser Leu Leu Gly Cys Ser Ile Asp Ile Ser Ser
                245                 250                 255     
Val Leu Asp Met Glu Ala Ile Thr Phe Lys Lys Leu Val Lys Gly His
            260                 265                 270         
Ala Tyr Ser Val Thr Gly Ala Lys Gln Val Asn Tyr Arg Gly Gln Val
        275                 280                 285             
Val Ser Leu Ile Arg Met Arg Asn Pro Trp Gly Glu Val Glu Trp Thr
    290                 295                 300                 
Gly Ala Trp Ser Asp Ser Ser Ser Glu Trp Asn Asn Val Asp Pro Tyr
305                 310                 315                 320 
Glu Arg Asp Gln Leu Arg Val Lys Met Glu Asp Gly Glu Phe Trp Met
                325                 330                 335     
Ser Phe Arg Asp Phe Met Arg Glu Phe Thr Arg Leu Glu Ile Cys Asn
            340                 345                 350         
Leu Thr Pro Asp Ala Leu Lys Ser Arg Thr Ile Arg Lys Trp Asn Thr
        355                 360                 365             
Thr Leu Tyr Glu Gly Thr Trp Arg Arg Gly Ser Thr Ala Gly Gly Cys
    370                 375                 380                 
Arg Asn Tyr Pro Ala Thr Phe Trp Val Asn Pro Gln Phe Lys Ile Arg
385                 390                 395                 400 
Leu Asp Glu Thr Asp Asp Pro Asp Asp Tyr Gly Asp Arg Glu Ser Gly
                405                 410                 415     
Cys Ser Phe Val Leu Ala Leu Met Gln Lys His Arg Arg Arg Glu Arg
            420                 425                 430         
Arg Phe Gly Arg Asp Met Glu Thr Ile Gly Phe Ala Val Tyr Glu Val
        435                 440                 445             
Pro Pro Glu Leu Val Gly Gln Pro Ala Val His Leu Lys Arg Asp Phe
    450                 455                 460                 
Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln Phe Ile Asn Leu
465                 470                 475                 480 
Arg Glu Val Ser Thr Arg Phe Arg Leu Pro Pro Gly Glu Tyr Val Val
                485                 490                 495     
Val Pro Ser Thr Phe Glu Pro Asn Lys Glu Gly Asp Phe Val Leu Arg
            500                 505                 510         
Phe Phe Ser Glu Lys Ser Ala Gly Thr Val Glu Leu Asp Asp Gln Ile
        515                 520                 525             
Gln Ala Asn Leu Pro Asp Glu Gln Val Leu Ser Glu Glu Glu Ile Asp
    530                 535                 540                 
Glu Asn Phe Lys Ala Leu Phe Arg Gln Leu Ala Gly Glu Asp Met Glu
545                 550                 555                 560 
Ile Ser Val Lys Glu Leu Arg Thr Ile Leu Asn Arg Ile Ile Ser Lys
                565                 570                 575     
His Lys Asp Leu Arg Thr Lys Gly Phe Ser Leu Glu Ser Cys Arg Ser
            580                 585                 590         
Met Val Asn Leu Met Asp Arg Asp Gly Asn Gly Lys Leu Gly Leu Val
        595                 600                 605             
Glu Phe Asn Ile Leu Trp Asn Arg Ile Arg Asn Tyr Leu Ser Ile Phe
    610                 615                 620                 
Arg Lys Phe Asp Leu Asp Lys Ser Gly Ser Met Ser Ala Tyr Glu Met
625                 630                 635                 640 
Arg Met Ala Ile Glu Ser Ala Gly Phe Lys Leu Asn Lys Lys Leu Tyr
                645                 650                 655     
Glu Leu Ile Ile Thr Arg Tyr Ser Glu Pro Asp Leu Ala Val Asp Phe
            660                 665                 670         
Asp Asn Phe Val Cys Cys Leu Val Arg Leu Glu Thr Met Phe Arg Phe
        675                 680                 685             
Phe Lys Thr Leu Asp Thr Asp Leu Asp Gly Val Val Thr Phe Asp Leu
    690                 695                 700                 
Phe Lys Trp Leu Gln Leu Thr Met Phe Ala
705                 710                 


<210> 6898
<211> 963
<212> PRT
<213> Homo sapiens

<400> 6898
Met Ala Val Ala Pro Arg Leu Phe Gly Gly Leu Cys Phe Arg Phe Arg
 1               5                  10                  15      
Asp Gln Asn Pro Glu Val Ala Val Glu Gly Arg Leu Pro Ile Ser His
            20                  25                  30          
Ser Cys Val Gly Cys Arg Arg Glu Arg Thr Ala Met Ala Thr Val Ala
        35                  40                  45              
Ala Asn Pro Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Val
    50                  55                  60                  
Thr Glu Asp Arg Glu Pro Gln His Glu Glu Leu Pro Gly Leu Asp Ser
65                  70                  75                  80  
Gln Trp Arg Gln Ile Glu Asn Gly Glu Ser Gly Arg Glu Arg Pro Leu
                85                  90                  95      
Arg Ala Gly Glu Ser Trp Phe Leu Val Glu Lys His Trp Tyr Lys Gln
            100                 105                 110         
Trp Glu Ala Tyr Val Gln Gly Gly Asp Gln Asp Ser Ser Thr Phe Pro
        115                 120                 125             
Gly Cys Ile Asn Asn Ala Thr Leu Phe Gln Asp Glu Ile Asn Trp Arg
    130                 135                 140                 
Leu Lys Glu Gly Leu Val Glu Gly Glu Asp Tyr Val Leu Leu Pro Ala
145                 150                 155                 160 
Ala Ala Trp His Tyr Leu Val Ser Trp Tyr Gly Leu Glu His Gly Gln
                165                 170                 175     
Pro Pro Ile Glu Arg Lys Val Ile Glu Leu Pro Asn Ile Gln Lys Val
            180                 185                 190         
Glu Val Tyr Pro Val Glu Leu Leu Leu Val Arg His Asn Asp Leu Gly
        195                 200                 205             
Lys Ser His Thr Val Gln Phe Ser His Thr Asp Ser Ile Gly Leu Val
    210                 215                 220                 
Leu Arg Thr Ala Arg Glu Arg Phe Leu Val Glu Pro Gln Glu Asp Thr
225                 230                 235                 240 
Arg Leu Trp Ala Lys Asn Ser Glu Gly Ser Leu Asp Arg Leu Tyr Asp
                245                 250                 255     
Thr His Ile Thr Val Leu Asp Ala Ala Leu Glu Thr Gly Gln Leu Ile
            260                 265                 270         
Ile Met Glu Thr Arg Lys Lys Asp Gly Thr Trp Pro Ser Ala Gln Leu
        275                 280                 285             
His Val Met Asn Asn Asn Met Ser Glu Glu Asp Glu Asp Phe Lys Gly
    290                 295                 300                 
Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys Phe Met
305                 310                 315                 320 
Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr Glu Tyr
                325                 330                 335     
Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn Pro Leu
            340                 345                 350         
Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val Lys Gln
        355                 360                 365             
Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe Lys Asn
    370                 375                 380                 
Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln His Asp
385                 390                 395                 400 
Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu Asp Leu
                405                 410                 415     
Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala Ala Gly
            420                 425                 430         
Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His Lys Arg
        435                 440                 445             
Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe Lys Ser
    450                 455                 460                 
Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe Asp Pro
465                 470                 475                 480 
Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg Val Leu
                485                 490                 495     
Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu Gln His
            500                 505                 510         
Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys Val Ala
        515                 520                 525             
Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val Ala Asp
    530                 535                 540                 
Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu Pro Leu
545                 550                 555                 560 
Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val Ser Gly
                565                 570                 575     
Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val Pro Val
            580                 585                 590         
Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser Tyr Tyr
        595                 600                 605             
Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro Arg Asp
    610                 615                 620                 
Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg Leu Ser
625                 630                 635                 640 
Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly Asp Glu
                645                 650                 655     
Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro Ser Thr
            660                 665                 670         
Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro Ser Ser
        675                 680                 685             
Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu Gly Thr
    690                 695                 700                 
Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr Leu Gln
705                 710                 715                 720 
Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro Glu Glu
                725                 730                 735     
Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu Met Lys
            740                 745                 750         
Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys His Asp
        755                 760                 765             
Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln Glu Cys
    770                 775                 780                 
Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn Pro Trp
785                 790                 795                 800 
Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys Leu Asp
                805                 810                 815     
Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg Phe Ser
            820                 825                 830         
Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu Phe Pro
        835                 840                 845             
Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln Asn Glu
    850                 855                 860                 
Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser Asn His
865                 870                 875                 880 
Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys Asn Lys
                885                 890                 895     
Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser Pro Val
            900                 905                 910         
Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe Tyr Gln
        915                 920                 925             
Arg Gln Asp Val Ala Arg Arg Leu Leu Ser Pro Ala Gly Ser Ser Gly
    930                 935                 940                 
Ala Pro Ala Ser Pro Ala Cys Ser Ser Pro Pro Ser Ser Glu Phe Met
945                 950                 955                 960 
Asp Val Asn
            


<210> 6899
<211> 546
<212> PRT
<213> Homo sapiens

<400> 6899
Met Asn Glu Leu Ser Cys Thr Asn Glu Leu Val Val Asn Lys Val Glu
 1               5                  10                  15      
Ser Glu Cys Val Leu Asn Gln Gln Val Ser Leu Asn Ser Gln Glu His
            20                  25                  30          
Ala Asn Leu Pro Thr Asp Ser Leu Leu His Leu Asn Lys Glu Met Pro
        35                  40                  45              
Leu Ala Thr Gly Arg Asp Ala His Gln Ser His His Pro Pro Leu Glu
    50                  55                  60                  
Gly Arg Ala Asp Val Ile Ala Asp Ile Gln Thr Ile Pro Ile Gln Thr
65                  70                  75                  80  
Lys Ile Lys Asp Ile Ser Pro Pro Gly Asn Gln Thr Cys Gly Ala Ser
                85                  90                  95      
Ser Asn Cys Pro Thr Leu Asn Ile Lys Pro Val Ser Leu Glu Arg Lys
            100                 105                 110         
Lys Glu Met Ala Asp Ser Gly Thr Lys Ala Leu His Ser Arg Leu Arg
        115                 120                 125             
Ser Asn Lys Arg Glu Ala Ala Gly Phe Pro Gln Val Val Ser Val Ile
    130                 135                 140                 
Glu Cys His Ser Val Gln Ser Gln Asp Ile Ser Ser Cys His Arg Val
145                 150                 155                 160 
Arg Lys Asn Val Ser Gln Glu Asn Met Cys Ser Ala Ser Ala Ala Phe
                165                 170                 175     
Lys Ser Ser Lys Ile Ser Leu Gln Val Asp Asn Ser Leu Ile Thr Lys
            180                 185                 190         
Tyr Glu Asn Ala Phe Gln His Arg Asp His Cys Cys Gln Gly Thr Gly
        195                 200                 205             
His Ser Val Glu Lys Ser Ser Cys Lys Val Ser Tyr Thr Ser Gln Glu
    210                 215                 220                 
Arg Glu Leu Asp Gly Lys Glu Thr Asn Gly Ser Leu Pro Gly Asp Lys
225                 230                 235                 240 
Ile Arg Asn Lys Met Val Ala Gly Leu Leu Asn Ser Gly Asn Ser Asn
                245                 250                 255     
Lys Thr Ile His Thr Ser Ser Ser Ile Lys Leu Ser Glu Glu Gly Leu
            260                 265                 270         
Glu Gly Lys Glu Gln Asp Val Ser Lys Glu Thr Val Phe Cys Lys Tyr
        275                 280                 285             
Asn Ile Ser Asp His Ala Ile Gln Glu Leu Asn Gln Thr Val Asn Ile
    290                 295                 300                 
Pro Gly Pro Glu Lys Val Leu Asp Gln Ser Pro Thr Val Met Phe Ser
305                 310                 315                 320 
Ser Phe Lys Asn Val Lys Ser Val Glu Thr Leu Asp Gln Lys Ala Asp
                325                 330                 335     
Glu Val Leu Asp Cys Gln Ser Asn Gln Asn Arg Pro Asp Glu Cys Lys
            340                 345                 350         
Ser Glu Gly Gln Ser Ala Lys Glu Met Leu Ser Ser Asp Gln Arg Glu
        355                 360                 365             
Thr Val Thr Glu Pro His Gly Glu Val Asn His Asn Gln Lys Asp Leu
    370                 375                 380                 
Leu Val Ser Ser Gly Ser Asn Asn Ser Leu Pro Cys Gly Ser Pro Lys
385                 390                 395                 400 
Lys Cys Asn Leu Lys Gly Ala Phe Val Lys Met Ser Gly Cys Asp Glu
                405                 410                 415     
Ser Thr Glu Gly Met Val Asp Ile Val Tyr Thr Asp Cys Ser Asn Lys
            420                 425                 430         
Leu Ala Glu Gly Val Leu Asp Val Lys Ala Ser Asn Leu Leu Asp Cys
        435                 440                 445             
Gly Ala Arg Gln Glu Lys Leu Ala Phe Gln Glu Asp Ser Arg Ser Thr
    450                 455                 460                 
Leu Ser Arg Arg Glu Leu Asp Ala Ala His Thr Gly Thr Thr Gly Gln
465                 470                 475                 480 
Asp Ser Asp Phe Pro Val Thr Ala Ala Ser Thr Val Asp Phe Leu Lys
                485                 490                 495     
Ile Lys Lys Ser Cys Glu Glu Asn Val Cys Arg Ser Leu Lys Asp Cys
            500                 505                 510         
Glu Met Glu Lys Cys Pro Asp Ser Cys Ala His Glu Met Glu Ser Val
        515                 520                 525             
Ala Asp His Glu Pro Asn Lys Arg Ile Leu Gly Arg Val Asn Phe Val
    530                 535                 540                 
Phe Lys
545     


<210> 6900
<211> 642
<212> PRT
<213> Homo sapiens

<400> 6900
Met Lys Arg Ser Ser Val Ser Ser Gly Gly Ala Gly Arg Leu Ser Met
 1               5                  10                  15      
Gln Glu Leu Arg Ser Gln Asp Val Asn Lys Gln Gly Leu Tyr Thr Pro
            20                  25                  30          
Gln Thr Lys Glu Lys Pro Thr Phe Gly Lys Leu Ser Ile Asn Lys Pro
        35                  40                  45              
Thr Ser Glu Arg Lys Val Ser Leu Phe Gly Lys Arg Thr Ser Gly His
    50                  55                  60                  
Gly Ser Arg Asn Ser Gln Leu Gly Ile Phe Ser Ser Ser Glu Lys Ile
65                  70                  75                  80  
Lys Asp Pro Arg Pro Leu Asn Asp Lys Ala Phe Ile Gln Gln Cys Ile
                85                  90                  95      
Arg Gln Leu Cys Glu Phe Leu Thr Glu Asn Gly Tyr Ala His Asn Val
            100                 105                 110         
Ser Met Lys Ser Leu Gln Ala Pro Ser Val Lys Asp Phe Leu Lys Ile
        115                 120                 125             
Phe Thr Phe Leu Tyr Gly Phe Leu Cys Pro Ser Tyr Glu Leu Pro Asp
    130                 135                 140                 
Thr Lys Phe Glu Glu Glu Val Pro Arg Ile Phe Lys Asp Leu Gly Tyr
145                 150                 155                 160 
Pro Phe Ala Leu Ser Lys Ser Ser Met Tyr Thr Val Gly Ala Pro His
                165                 170                 175     
Thr Trp Pro His Ile Val Ala Ala Leu Val Trp Leu Ile Asp Cys Ile
            180                 185                 190         
Lys Ile His Thr Ala Met Lys Glu Ser Ser Pro Leu Phe Asp Asp Gly
        195                 200                 205             
Gln Pro Trp Gly Glu Glu Thr Glu Asp Gly Ile Met His Asn Lys Leu
    210                 215                 220                 
Phe Leu Asp Tyr Thr Ile Lys Cys Tyr Glu Ser Phe Met Ser Gly Ala
225                 230                 235                 240 
Asp Ser Phe Asp Glu Met Asn Ala Glu Leu Gln Ser Lys Leu Lys Asp
                245                 250                 255     
Leu Phe Asn Val Asp Ala Phe Lys Leu Glu Ser Leu Glu Ala Lys Asn
            260                 265                 270         
Arg Ala Leu Asn Glu Gln Ile Ala Arg Leu Glu Gln Glu Arg Glu Lys
        275                 280                 285             
Glu Pro Asn Arg Leu Glu Ser Leu Arg Lys Leu Lys Ala Ser Leu Gln
    290                 295                 300                 
Gly Asp Val Gln Lys Tyr Gln Ala Tyr Met Ser Asn Leu Glu Ser His
305                 310                 315                 320 
Ser Ala Ile Leu Asp Gln Lys Leu Asn Gly Leu Asn Glu Glu Ile Ala
                325                 330                 335     
Arg Val Glu Leu Glu Cys Glu Thr Ile Lys Gln Glu Asn Thr Arg Leu
            340                 345                 350         
Gln Asn Ile Ile Asp Asn Gln Lys Tyr Ser Val Ala Asp Ile Glu Arg
        355                 360                 365             
Ile Asn His Glu Arg Asn Glu Leu Gln Gln Thr Ile Asn Lys Leu Thr
    370                 375                 380                 
Lys Asp Leu Glu Ala Glu Gln Gln Lys Leu Trp Asn Glu Glu Leu Lys
385                 390                 395                 400 
Tyr Ala Arg Gly Lys Glu Ala Ile Glu Thr Gln Leu Ala Glu Tyr His
                405                 410                 415     
Lys Leu Ala Arg Lys Leu Lys Leu Ile Pro Lys Gly Ala Glu Asn Ser
            420                 425                 430         
Lys Gly Tyr Asp Phe Glu Ile Lys Phe Asn Pro Glu Ala Gly Ala Asn
        435                 440                 445             
Cys Leu Val Lys Tyr Arg Ala Gln Val Tyr Val Pro Leu Lys Glu Leu
    450                 455                 460                 
Leu Asn Glu Thr Glu Glu Glu Ile Asn Lys Ala Leu Asn Lys Lys Met
465                 470                 475                 480 
Gly Leu Glu Asp Thr Leu Glu Gln Leu Asn Ala Met Ile Thr Glu Ser
                485                 490                 495     
Lys Arg Ser Val Arg Thr Leu Lys Glu Glu Val Gln Lys Leu Asp Asp
            500                 505                 510         
Leu Tyr Gln Gln Lys Ile Lys Glu Ala Glu Glu Glu Asp Glu Lys Cys
        515                 520                 525             
Ala Ser Glu Leu Glu Ser Leu Glu Lys His Lys His Leu Leu Glu Ser
    530                 535                 540                 
Thr Val Asn Gln Gly Leu Ser Glu Ala Met Asn Glu Leu Asp Ala Val
545                 550                 555                 560 
Gln Arg Glu Tyr Gln Leu Val Val Gln Thr Thr Thr Glu Glu Arg Arg
                565                 570                 575     
Lys Val Gly Asn Asn Leu Gln Arg Leu Leu Glu Met Val Ala Thr His
            580                 585                 590         
Val Gly Ser Val Glu Lys His Leu Glu Glu Gln Ile Ala Lys Val Asp
        595                 600                 605             
Arg Glu Tyr Glu Glu Cys Met Ser Glu Asp Leu Ser Glu Asn Ile Lys
    610                 615                 620                 
Glu Ile Arg Asp Lys Tyr Glu Lys Lys Ala Thr Leu Ile Lys Ser Ser
625                 630                 635                 640 
Glu Glu
        


<210> 6901
<211> 2376
<212> PRT
<213> Homo sapiens

<400> 6901
Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu
 1               5                  10                  15      
Val Asp Asn Leu Thr Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile
            20                  25                  30          
Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu
        35                  40                  45              
Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser
    50                  55                  60                  
Gly Lys Asp Phe His Gln Thr Gln Phe Leu Ile Gln Glu Cys Ala Leu
65                  70                  75                  80  
Leu Ile Thr Lys Pro Asn Phe Ile Ser Thr Leu Ser Tyr Ala Ile Asp
                85                  90                  95      
Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe
            100                 105                 110         
Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile
        115                 120                 125             
Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe
    130                 135                 140                 
Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr
145                 150                 155                 160 
Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile
                165                 170                 175     
Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln
            180                 185                 190         
Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys
        195                 200                 205             
Thr Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala
    210                 215                 220                 
Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu
225                 230                 235                 240 
Pro Asp Ser Gly Gly Val Ala Lys Thr Met Met Glu Ser Ser Leu Ala
                245                 250                 255     
Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu
            260                 265                 270         
Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Thr Ala Ala
        275                 280                 285             
Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Thr His Ser Gly Leu
    290                 295                 300                 
Thr Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile
305                 310                 315                 320 
Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Thr Trp
                325                 330                 335     
Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu
            340                 345                 350         
Asn Phe Lys Glu Val Thr Tyr Glu Leu Asp His Pro Gly Phe Gln Ile
        355                 360                 365             
Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly
    370                 375                 380                 
Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys
385                 390                 395                 400 
His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro
                405                 410                 415     
Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Thr Val Ala Thr Asp
            420                 425                 430         
Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Thr Trp
        435                 440                 445             
Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly
    450                 455                 460                 
Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys
465                 470                 475                 480 
Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Thr Ser Trp His
                485                 490                 495     
Thr Leu Arg His Glu Leu Ile Ser Thr Leu Met Pro Ile Phe Leu Gly
            500                 505                 510         
Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln
        515                 520                 525             
Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu
    530                 535                 540                 
Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile
545                 550                 555                 560 
Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly
                565                 570                 575     
Thr Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg
            580                 585                 590         
Glu Tyr Leu Lys Leu Asp Lys Trp Leu Thr Asp Lys Ile Arg Glu His
        595                 600                 605             
Gly Glu Pro Phe Ile Gln Ala Cys Met Thr Phe Leu Lys Arg Arg Cys
    610                 615                 620                 
Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser
625                 630                 635                 640 
Ala Gln Leu Pro Pro Glu Thr Leu Ala Thr Met Leu Ala Cys Leu Gln
                645                 650                 655     
Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Thr Ile Leu Thr
            660                 665                 670         
Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro
        675                 680                 685             
Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp
    690                 695                 700                 
Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Thr Ser Leu
705                 710                 715                 720 
Ser Ile Gly Gly Ser Ala Ala Pro His Thr Gln Ser Met Gln Gly Phe
                725                 730                 735     
Pro Pro Asn Leu Gly Ser Ala Phe Ser Thr Pro Gln Ser Pro Ala Lys
            740                 745                 750         
Ala Phe Pro Pro Leu Ser Thr Pro Asn Gln Thr Thr Ala Phe Ser Gly
        755                 760                 765             
Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Thr Gly
    770                 775                 780                 
Ser Leu Thr Gly Ile Gly Thr Gly Ala Leu Gly Leu Pro Ala Val Asn
785                 790                 795                 800 
Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Thr Ser Gly Leu Asn Gln
                805                 810                 815     
Pro Thr Phe Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln Val
            820                 825                 830         
Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala
        835                 840                 845             
Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Thr Met
    850                 855                 860                 
Ser Val Asp Glu Val Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Thr
865                 870                 875                 880 
Ile Lys Arg Glu Arg Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe
                885                 890                 895     
Glu Glu Tyr Arg Phe Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile
            900                 905                 910         
Thr Ala Cys Leu Phe Gly Gly Ile Ile Glu Lys Gly Leu Val Thr Tyr
        915                 920                 925             
Met Ala Leu Gly Leu Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys
    930                 935                 940                 
Pro Phe Gly Ser Lys Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg
945                 950                 955                 960 
Phe Lys Asn Arg Leu Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala
                965                 970                 975     
Ser Ile Ser His Phe Met Gln Phe Pro His His Leu Gln Glu Tyr Ile
            980                 985                 990         
Glu Tyr Gly Gln Gln Ser Arg Asp Pro Pro Val Lys Thr Gln Gly Ser
        995                 1000                1005            
Ile Thr Thr Pro Gly Ser Ile Ala Leu Ala Gln Ala Gln Ala Gln Ala
    1010                1015                1020                
Gln Val Pro Ala Lys Ala Pro Leu Ala Gly Gln Val Ser Thr Met Val
1025                1030                1035                1040
Thr Thr Ser Thr Thr Thr Thr Val Ala Lys Thr Val Thr Val Thr Arg
                1045                1050                1055    
Pro Thr Gly Val Ser Phe Lys Lys Asp Val Pro Pro Ser Ile Asn Thr
            1060                1065                1070        
Thr Asn Ile Asp Thr Leu Leu Val Ala Thr Asp Gln Thr Glu Arg Ile
        1075                1080                1085            
Val Glu Pro Pro Glu Asn Ile Gln Glu Lys Ile Ala Phe Ile Phe Asn
    1090                1095                1100                
Asn Leu Ser Gln Ser Asn Met Thr Gln Lys Val Glu Glu Leu Lys Glu
1105                1110                1115                1120
Thr Val Lys Glu Glu Phe Met Pro Trp Val Ser Gln Tyr Leu Val Met
                1125                1130                1135    
Arg Arg Val Ser Ile Glu Pro Asn Phe His Ser Leu Tyr Ser Asn Phe
            1140                1145                1150        
Leu Asp Thr Leu Lys Asn Pro Glu Phe Asn Lys Met Val Leu Asn Glu
        1155                1160                1165            
Thr Tyr Arg Asn Ile Lys Val Leu Leu Thr Ser Asp Lys Ala Ala Ala
    1170                1175                1180                
Asn Phe Ser Asp Arg Ser Leu Leu Lys Asn Leu Gly His Trp Leu Gly
1185                1190                1195                1200
Met Ile Thr Leu Ala Lys Asn Lys Pro Ile Leu His Thr Asp Leu Asp
                1205                1210                1215    
Val Lys Ser Leu Leu Leu Glu Ala Tyr Val Lys Gly Gln Gln Glu Leu
            1220                1225                1230        
Leu Tyr Val Val Pro Phe Val Ala Lys Val Leu Glu Ser Ser Ile Arg
        1235                1240                1245            
Ser Val Val Phe Arg Pro Pro Asn Pro Trp Thr Met Ala Ile Met Asn
    1250                1255                1260                
Val Leu Ala Glu Leu His Gln Glu His Asp Leu Lys Leu Asn Leu Lys
1265                1270                1275                1280
Phe Glu Ile Glu Val Leu Cys Lys Asn Leu Ala Leu Asp Ile Asn Glu
                1285                1290                1295    
Leu Lys Pro Gly Asn Leu Leu Lys Asp Lys Asp Arg Leu Lys Asn Leu
            1300                1305                1310        
Asp Glu Gln Leu Ser Ala Pro Lys Lys Asp Val Lys Gln Pro Glu Glu
        1315                1320                1325            
Leu Pro Pro Ile Thr Thr Thr Thr Thr Ser Thr Thr Pro Ala Thr Asn
    1330                1335                1340                
Thr Thr Cys Thr Ala Thr Val Pro Pro Gln Pro Gln Tyr Ser Tyr His
1345                1350                1355                1360
Asp Ile Asn Val Tyr Ser Leu Ala Gly Leu Ala Pro His Ile Thr Leu
                1365                1370                1375    
Asn Pro Thr Ile Pro Leu Phe Gln Ala His Pro Gln Leu Lys Gln Cys
            1380                1385                1390        
Val Arg Gln Ala Ile Glu Arg Ala Val Gln Glu Leu Val His Pro Val
        1395                1400                1405            
Val Asp Arg Ser Ile Lys Ile Ala Met Thr Thr Cys Glu Gln Ile Val
    1410                1415                1420                
Arg Lys Asp Phe Ala Leu Asp Ser Glu Glu Ser Arg Met Arg Ile Ala
1425                1430                1435                1440
Ala His His Met Met Arg Asn Leu Thr Ala Gly Met Ala Met Ser Thr
                1445                1450                1455    
Cys Arg Glu Pro Leu Leu Met Ser Ile Ser Thr Asn Leu Lys Asn Ser
            1460                1465                1470        
Phe Ala Ser Ala Leu Arg Thr Ala Ser Pro Gln Gln Arg Glu Met Met
        1475                1480                1485            
Asp Gln Ala Ala Ala Gln Leu Ala Gln Asp Asn Cys Glu Leu Ala Cys
    1490                1495                1500                
Cys Phe Ile Gln Lys Thr Ala Val Glu Lys Ala Gly Pro Glu Met Asp
1505                1510                1515                1520
Lys Arg Leu Ala Thr Glu Phe Glu Leu Arg Lys His Ala Arg Gln Glu
                1525                1530                1535    
Gly Arg Arg Tyr Cys Asp Pro Val Val Leu Thr Tyr Gln Ala Glu Arg
            1540                1545                1550        
Met Pro Glu Gln Ile Arg Leu Lys Val Gly Gly Val Asp Pro Lys Gln
        1555                1560                1565            
Leu Ala Val Tyr Glu Glu Phe Ala Arg Asn Val Pro Gly Phe Leu Pro
    1570                1575                1580                
Thr Asn Asp Leu Ser Gln Pro Thr Gly Phe Leu Ala Gln Pro Met Lys
1585                1590                1595                1600
Gln Ala Trp Ala Thr Asp Asp Val Ala Gln Ile Tyr Asp Lys Cys Ile
                1605                1610                1615    
Thr Glu Leu Glu Gln His Leu His Ala Ile Pro Pro Thr Leu Ala Met
            1620                1625                1630        
Asn Pro Gln Ala Gln Ala Leu Arg Ser Leu Leu Glu Val Val Val Leu
        1635                1640                1645            
Ser Arg Asn Ser Arg Asp Ala Ile Ala Ala Leu Gly Leu Leu Gln Lys
    1650                1655                1660                
Ala Val Glu Gly Leu Leu Asp Ala Thr Ser Gly Val Asp Ala Asp Leu
1665                1670                1675                1680
Leu Leu Arg Tyr Arg Glu Cys His Leu Leu Val Leu Lys Ala Leu Gln
                1685                1690                1695    
Asp Gly Arg Ala Tyr Gly Ser Pro Trp Cys Asn Arg Gln Ile Thr Arg
            1700                1705                1710        
Cys Leu Ile Glu Cys Arg Asp Glu Tyr Lys Tyr Asn Val Glu Ala Val
        1715                1720                1725            
Glu Leu Leu Ile Arg Asn His Leu Val Asn Met Gln Gln Tyr Asp Leu
    1730                1735                1740                
His Leu Ala Gln Ser Met Glu Asn Gly Leu Asn Tyr Met Ala Val Ala
1745                1750                1755                1760
Phe Ala Met Gln Leu Val Lys Ile Leu Leu Val Asp Glu Arg Ser Val
                1765                1770                1775    
Ala His Val Thr Glu Ala Asp Leu Phe His Thr Ile Glu Thr Leu Met
            1780                1785                1790        
Arg Ile Asn Ala His Ser Arg Gly Asn Ala Pro Glu Gly Leu Pro Gln
        1795                1800                1805            
Leu Met Glu Val Val Arg Ser Asn Tyr Glu Ala Met Ile Asp Arg Ala
    1810                1815                1820                
His Gly Gly Pro Asn Phe Met Met His Ser Gly Ile Ser Gln Ala Ser
1825                1830                1835                1840
Glu Tyr Asp Asp Pro Pro Gly Leu Arg Glu Lys Ala Glu Tyr Leu Leu
                1845                1850                1855    
Arg Glu Trp Val Asn Leu Tyr His Ser Ala Ala Ala Gly Arg Asp Ser
            1860                1865                1870        
Thr Lys Ala Phe Ser Ala Phe Val Gly Gln Met His Gln Gln Gly Ile
        1875                1880                1885            
Leu Lys Thr Asp Asp Leu Ile Thr Arg Phe Phe Arg Leu Cys Thr Glu
    1890                1895                1900                
Met Cys Val Glu Ile Ser Tyr Arg Ala Gln Ala Glu Gln Gln His Asn
1905                1910                1915                1920
Pro Ala Ala Asn Pro Thr Met Ile Arg Ala Lys Cys Tyr His Asn Leu
                1925                1930                1935    
Asp Ala Phe Val Arg Leu Ile Ala Leu Leu Val Lys His Ser Gly Glu
            1940                1945                1950        
Ala Thr Asn Thr Val Thr Lys Ile Asn Leu Leu Asn Lys Val Leu Gly
        1955                1960                1965            
Ile Val Val Gly Val Leu Leu Gln Asp His Asp Val Arg Gln Ser Glu
    1970                1975                1980                
Phe Gln Gln Leu Pro Tyr His Arg Ile Phe Ile Met Leu Leu Leu Glu
1985                1990                1995                2000
Leu Asn Ala Pro Glu His Val Leu Glu Thr Ile Asn Phe Gln Thr Leu
                2005                2010                2015    
Thr Ala Phe Cys Asn Thr Phe His Ile Leu Arg Pro Thr Lys Ala Pro
            2020                2025                2030        
Gly Phe Val Tyr Ala Trp Leu Glu Leu Ile Ser His Arg Ile Phe Ile
        2035                2040                2045            
Ala Arg Met Leu Ala His Thr Pro Gln Gln Lys Gly Trp Pro Met Tyr
    2050                2055                2060                
Ala Gln Leu Leu Ile Asp Leu Phe Lys Tyr Leu Ala Pro Phe Leu Arg
2065                2070                2075                2080
Asn Val Glu Leu Thr Lys Pro Met Gln Ile Leu Tyr Lys Gly Thr Leu
                2085                2090                2095    
Arg Val Leu Leu Val Leu Leu His Asp Phe Pro Glu Phe Leu Cys Asp
            2100                2105                2110        
Tyr His Tyr Gly Phe Cys Asp Val Ile Pro Pro Asn Cys Ile Gln Leu
        2115                2120                2125            
Arg Asn Leu Ile Leu Ser Ala Phe Pro Arg Asn Met Arg Leu Pro Asp
    2130                2135                2140                
Pro Phe Thr Pro Asn Leu Lys Val Asp Met Leu Ser Glu Ile Asn Ile
2145                2150                2155                2160
Ala Pro Arg Ile Leu Thr Asn Phe Thr Gly Val Met Pro Pro Gln Phe
                2165                2170                2175    
Lys Lys Asp Leu Asp Ser Tyr Leu Lys Thr Arg Ser Pro Val Thr Phe
            2180                2185                2190        
Leu Ser Asp Leu Arg Ser Asn Leu Gln Val Ser Asn Glu Pro Gly Asn
        2195                2200                2205            
Arg Tyr Asn Leu Gln Leu Ile Asn Ala Leu Val Leu Tyr Val Gly Thr
    2210                2215                2220                
Gln Ala Ile Ala His Ile His Asn Lys Gly Ser Thr Pro Ser Met Ser
2225                2230                2235                2240
Thr Ile Thr His Ser Ala His Met Gly Ile Phe Gln Asn Leu Ala Val
                2245                2250                2255    
Asp Leu Asp Thr Glu Gly Arg Tyr Leu Phe Leu Asn Ala Ile Ala Asn
            2260                2265                2270        
Gln Leu Arg Tyr Pro Asn Ser His Thr His Tyr Phe Ser Cys Thr Met
        2275                2280                2285            
Leu Tyr Leu Phe Ala Glu Ala Asn Thr Glu Ala Ile Gln Glu Gln Ile
    2290                2295                2300                
Thr Arg Val Leu Leu Glu Arg Leu Ile Val Asn Arg Pro His Pro Trp
2305                2310                2315                2320
Gly Leu Leu Ile Thr Phe Ile Glu Leu Ile Lys Asn Pro Ala Phe Lys
                2325                2330                2335    
Phe Trp Asn His Glu Phe Val His Cys Ala Pro Glu Ile Glu Lys Leu
            2340                2345                2350        
Phe Gln Ser Val Ala Gln Cys Cys Met Gly Gln Lys Gln Ala Gln Gln
        2355                2360                2365            
Val Met Glu Gly Thr Gly Ala Ser
    2370                2375    


<210> 6902
<211> 838
<212> PRT
<213> Homo sapiens

<400> 6902
Val Lys Glu Thr His Leu Pro Lys Val Val Leu Val Asp Leu Val Pro
 1               5                  10                  15      
Gly Asp Ser Asp Tyr Glu Val Ile Ser Asp Asp Ile Pro Leu Gln Leu
            20                  25                  30          
Val Thr Asp Pro Pro Gln Leu Thr Val Lys Asp Ile Ser Cys Ile Asn
        35                  40                  45              
Thr Glu Cys Ile Asp Ile Glu Asp Lys Ser Cys Asp Phe Phe Gly Ser
    50                  55                  60                  
Glu Val Arg Cys Asn Cys Lys Ala Ser Thr Pro Ser Met Thr Asn Gln
65                  70                  75                  80  
Cys Lys Glu Thr Phe Lys Ile Ile Asn Arg Lys Lys Asp Tyr Ile Ile
                85                  90                  95      
Leu Gly Glu Pro Ser Cys Gln Ser Cys Gly Ser Glu Met Asn Phe Asn
            100                 105                 110         
Val Asp Ala Ser Asp Gln Ser Met Thr Tyr Glu Ser Gln Gly Pro Asp
        115                 120                 125             
Glu Lys Met Val Lys Tyr Ile Asp Ser Glu Asp Lys Ser Cys Gly Tyr
    130                 135                 140                 
Asn Gly Ser Lys Gly Lys Phe Asn Leu Glu Asp Thr Ser His Arg Thr
145                 150                 155                 160 
Thr His Arg Leu Gln Lys Ala His Lys Glu Ala Ser Leu Arg Lys Asp
                165                 170                 175     
Pro Arg Asn Ala Gly Leu Lys Gly Lys Ser Cys Gln Ser Ser Ala Ser
            180                 185                 190         
Ala Val Asp Phe Gly Ala Ser Ser Lys Ser Ala Leu His Arg Arg Ala
        195                 200                 205             
Asp Lys Lys Lys Arg Ser Lys Leu Lys His Arg Asp Leu Glu Val Ser
    210                 215                 220                 
Cys Glu Pro Asp Gly Phe Glu Met Asn Phe Gln Cys Ala Pro Pro Leu
225                 230                 235                 240 
Pro Ser Asp Thr Asp Gln Pro Gln Glu Thr Val Lys Lys Arg His Pro
                245                 250                 255     
Cys Lys Lys Val Ser Ser Asp Leu Lys Glu Lys Asn His Asp Ser Gln
            260                 265                 270         
Ser Ser Ser Val Leu Lys Val Asp Ser Val Arg Asn Leu Lys Lys Ala
        275                 280                 285             
Lys Asp Val Ile Glu Asp Asn Pro Asp Glu Pro Val Leu Glu Ala Leu
    290                 295                 300                 
Pro His Val Pro Pro Ser Phe Val Gly Lys Thr Trp Ser Gln Ile Met
305                 310                 315                 320 
Arg Glu Asp Asp Ile Lys Ile Asn Ala Leu Val Lys Glu Phe Arg Glu
                325                 330                 335     
Gly Arg Phe His Cys Tyr Phe Asp Asp Asp Cys Glu Thr Lys Lys Val
            340                 345                 350         
Ser Ser Lys Gly Lys Lys Lys Val Thr Trp Ala Asp Leu Gln Gly Lys
        355                 360                 365             
Glu Asp Thr Ala Pro Thr Gln Ala Val Ser Glu Ser Asp Asp Ile Val
    370                 375                 380                 
Cys Gly Ile Ser Asp Ile Asp Asp Leu Ser Val Ala Leu Asp Lys Pro
385                 390                 395                 400 
Cys His Arg His Pro Pro Ala Glu Arg Pro Pro Lys Gln Lys Gly Arg
                405                 410                 415     
Val Ala Ser Gln Cys Gln Thr Ala Lys Ile Ser His Ser Thr Gln Thr
            420                 425                 430         
Ser Cys Lys Asn Tyr Pro Val Met Lys Arg Lys Ile Ile Arg Gln Glu
        435                 440                 445             
Glu Asp Pro Pro Lys Ser Lys Cys Ser Arg Leu Gln Asp Asp Arg Lys
    450                 455                 460                 
Thr Lys Lys Lys Val Lys Ile Gly Thr Val Glu Phe Pro Ala Ser Cys
465                 470                 475                 480 
Thr Lys Val Leu Lys Pro Met Gln Pro Lys Ala Leu Val Cys Val Leu
                485                 490                 495     
Ser Ser Leu Asn Ile Lys Leu Lys Glu Gly Glu Gly Leu Pro Phe Pro
            500                 505                 510         
Lys Met Arg His His Ser Trp Asp Asn Asp Ile Arg Phe Ile Cys Lys
        515                 520                 525             
Tyr Lys Arg Asn Ile Phe Asp Tyr Tyr Glu Pro Leu Ile Lys Gln Ile
    530                 535                 540                 
Val Ile Ser Pro Pro Leu Ser Val Ile Val Pro Glu Phe Glu Arg Arg
545                 550                 555                 560 
Asn Trp Val Lys Ile His Phe Asn Arg Ser Asn Gln Asn Ser Ser Ala
                565                 570                 575     
Gly Asp Asn Asp Ala Asp Gly Gln Gly Ser Ala Ser Ala Pro Leu Met
            580                 585                 590         
Ala Val Pro Ala Arg Tyr Gly Phe Asn Ser His Gln Gly Thr Ser Asp
        595                 600                 605             
Ser Ser Leu Phe Leu Glu Glu Ser Lys Val Leu His Ala Arg Glu Leu
    610                 615                 620                 
Pro Lys Lys Arg Asn Phe Gln Leu Thr Phe Leu Asn His Asp Val Val
625                 630                 635                 640 
Lys Ile Ser Pro Lys Ser Val Arg Asn Lys Leu Leu Glu Ser Gln Ser
                645                 650                 655     
Lys Lys Lys Ile His Gly Lys Arg Val Thr Thr Ser Ser Asn Lys Leu
            660                 665                 670         
Gly Phe Pro Lys Lys Val Tyr Lys Pro Ile Ile Leu Gln Gln Lys Pro
        675                 680                 685             
Arg Lys Ala Ser Glu Lys Gln Ser Ile Trp Ile Arg Thr Lys Pro Ser
    690                 695                 700                 
Asp Ile Ile Arg Lys Tyr Ile Ser Lys Tyr Ser Val Phe Leu Arg His
705                 710                 715                 720 
Arg Tyr Gln Ser Arg Ser Ala Phe Leu Gly Arg Tyr Leu Lys Lys Lys
                725                 730                 735     
Lys Ser Val Val Ser Arg Leu Lys Lys Ala Lys Arg Thr Ala Lys Val
            740                 745                 750         
Leu Leu Asn Ser Ser Val Pro Pro Ala Gly Ala Glu Glu Leu Ser Ser
        755                 760                 765             
Ala Met Ala Asn Pro Pro Pro Lys Arg Pro Val Arg Ala Ser Cys Arg
    770                 775                 780                 
Val Ala Arg Arg Arg Lys Lys Thr Asp Glu Ser Tyr His Gly Arg Gln
785                 790                 795                 800 
Lys Gly Pro Ser Thr Pro Val Arg Ala Tyr Asp Leu Arg Ser Ser Ser
                805                 810                 815     
Cys Leu Gln Gln Arg Glu Arg Met Met Thr Arg Leu Ala Asn Lys Leu
            820                 825                 830         
Arg Gly Asn Glu Val Lys
        835             


<210> 6903
<211> 388
<212> PRT
<213> Homo sapiens

<400> 6903
Met Leu Asn Gly Thr Thr Leu Glu Ala Ala Met Leu Phe His Gly Ile
 1               5                  10                  15      
Ser Gly Gly His Ile Gln Gly Ile Met Glu Glu Met Glu Arg Arg Ser
            20                  25                  30          
Lys Thr Glu Ala Arg Leu Ala Lys Gly Ala Gln Leu Asn Gly Arg Asp
        35                  40                  45              
Ala Gly Met Pro Pro Leu Ser Pro Glu Lys Pro Ala Leu Cys Ala Gly
    50                  55                  60                  
Cys Gly Gly Lys Ile Ser Asp Arg Tyr Tyr Leu Leu Ala Val Asp Lys
65                  70                  75                  80  
Gln Trp His Leu Arg Cys Leu Lys Cys Cys Glu Cys Lys Leu Ala Leu
                85                  90                  95      
Glu Ser Glu Leu Thr Cys Phe Ala Lys Asp Gly Ser Ile Tyr Cys Lys
            100                 105                 110         
Glu Asp Tyr Tyr Arg Arg Phe Ser Val Gln Arg Cys Ala Arg Cys His
        115                 120                 125             
Leu Gly Ile Ser Ala Ser Glu Met Val Met Arg Ala Arg Asp Ser Val
    130                 135                 140                 
Tyr His Leu Ser Cys Phe Thr Cys Ser Thr Cys Asn Lys Thr Leu Thr
145                 150                 155                 160 
Thr Gly Asp His Phe Gly Met Lys Asp Ser Leu Val Tyr Cys Arg Ala
                165                 170                 175     
His Phe Glu Thr Leu Leu Gln Gly Glu Tyr Pro Pro Gln Leu Ser Tyr
            180                 185                 190         
Thr Glu Leu Ala Ala Lys Ser Gly Gly Leu Ala Leu Pro Tyr Phe Asn
        195                 200                 205             
Gly Thr Gly Thr Val Gln Lys Gly Arg Pro Arg Lys Arg Lys Ser Pro
    210                 215                 220                 
Ala Leu Gly Val Asp Ile Val Asn Tyr Asn Ser Gly Cys Asn Glu Asn
225                 230                 235                 240 
Glu Ala Asp His Leu Asp Arg Asp Gln Gln Pro Tyr Pro Pro Ser Gln
                245                 250                 255     
Lys Thr Lys Arg Met Arg Thr Ser Phe Lys His His Gln Leu Arg Thr
            260                 265                 270         
Met Lys Ser Tyr Phe Ala Ile Asn His Asn Pro Asp Ala Lys Asp Leu
        275                 280                 285             
Lys Gln Leu Ala Gln Lys Thr Gly Leu Thr Lys Arg Val Leu Gln Val
    290                 295                 300                 
Trp Phe Gln Asn Ala Arg Ala Lys Phe Arg Arg Asn Leu Leu Arg Gln
305                 310                 315                 320 
Glu Asn Gly Gly Val Asp Lys Ala Asp Gly Thr Ser Leu Pro Ala Pro
                325                 330                 335     
Pro Ser Ala Asp Ser Gly Ala Leu Thr Pro Pro Gly Thr Ala Thr Thr
            340                 345                 350         
Leu Thr Asp Leu Thr Asn Pro Thr Ile Thr Val Val Thr Ser Val Thr
        355                 360                 365             
Ser Asn Met Asp Ser His Glu Ser Gly Ser Pro Ser Gln Thr Thr Leu
    370                 375                 380                 
Thr Asn Leu Phe
385             


<210> 6904
<211> 390
<212> PRT
<213> Homo sapiens

<400> 6904
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Ser Lys Tyr Ser His Ser Ser Ser Pro
        35                  40                  45              
Gln Glu Lys Pro Val Ala Asp Ser Val Val Leu Ser Phe Asp Ser Ala
    50                  55                  60                  
Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu Asn
65                  70                  75                  80  
Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn Phe
                85                  90                  95      
Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr Ala
            100                 105                 110         
Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp Ser
        115                 120                 125             
Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly Ile
    130                 135                 140                 
Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys Glu
145                 150                 155                 160 
Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys Ile
                165                 170                 175     
Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser Arg
            180                 185                 190         
Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val Lys
        195                 200                 205             
Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr Tyr
    210                 215                 220                 
Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser Leu
225                 230                 235                 240 
Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys Tyr
                245                 250                 255     
Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp Lys Ser
            260                 265                 270         
Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile Leu Asn
        275                 280                 285             
Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu Pro Phe
    290                 295                 300                 
Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly Ser Val
305                 310                 315                 320 
Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val Ala Gly
                325                 330                 335     
Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr Tyr Glu
            340                 345                 350         
Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn Ile Gln
        355                 360                 365             
Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile Thr
    370                 375                 380                 
Asp Leu Ser Ser Gly Ile
385                 390 


<210> 6905
<211> 230
<212> PRT
<213> Homo sapiens

<400> 6905
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Lys Tyr Asp Arg Leu Gly Phe Leu Leu
        35                  40                  45              
Asn Leu Asp Ser Lys Leu Phe Ser Lys Pro Ala Pro Met Phe Leu Asp
    50                  55                  60                  
Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe
65                  70                  75                  80  
Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr
                85                  90                  95      
Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg
            100                 105                 110         
Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly
        115                 120                 125             
Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro
    130                 135                 140                 
Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile
145                 150                 155                 160 
Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp
                165                 170                 175     
Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu
            180                 185                 190         
Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Trp Thr His Ser Ile Gln
        195                 200                 205             
Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile Thr
    210                 215                 220                 
Asp Leu Ser Ser Gly Ile
225                 230 


<210> 6906
<211> 228
<212> PRT
<213> Homo sapiens

<400> 6906
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Lys Tyr Asp Arg Leu Gly Phe Leu Leu
        35                  40                  45              
Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn
    50                  55                  60                  
Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Ser Met Thr
65                  70                  75                  80  
Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp
                85                  90                  95      
Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Leu Val Pro Pro Phe Gly
            100                 105                 110         
Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys
        115                 120                 125             
Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys
    130                 135                 140                 
Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser
145                 150                 155                 160 
Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Val His Arg Met Ala Ser
                165                 170                 175     
Gly Asn Leu Trp Pro Leu Glu Cys Pro Arg Ser Pro Leu Arg Phe Glu
            180                 185                 190         
Ser Ser Thr His Ile Ser Ser Arg Arg Pro Pro Ser Pro Ser Leu Ala
        195                 200                 205             
Cys Pro Ser Thr Met Ala Ser Trp Ala Gly Gly Thr Ser Leu Pro Leu
    210                 215                 220                 
Ala Val Trp Gln
225             


<210> 6907
<211> 444
<212> PRT
<213> Homo sapiens

<400> 6907
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Ser Lys Tyr Ser His Ser Ser Ser Pro
        35                  40                  45              
Gln Glu Lys Pro Val Ala Asp Ser Val Val Leu Ser Phe Asp Ser Ala
    50                  55                  60                  
Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu Asn
65                  70                  75                  80  
Leu Asp Ser Lys Leu Ser Pro Arg Thr Leu Cys Thr Val Val Phe Gly
                85                  90                  95      
Leu Asp Cys Ile Leu Glu Ser Pro Gly Glu Pro Lys Lys Leu Leu Met
            100                 105                 110         
Pro Ala Ser His Pro Leu Glu Ile Leu Lys Ser Leu Ser Glu Asp Thr
        115                 120                 125             
Ala Phe Ala Leu Gly Phe Leu Lys Leu Pro Arg Pro Ala Glu Leu Ala
    130                 135                 140                 
Thr Lys Tyr Ala Asn Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala
145                 150                 155                 160 
Ser Ala Leu Met Thr Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro
                165                 170                 175     
Met Phe Leu Asp Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe
            180                 185                 190         
Val Pro Pro Phe Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile
        195                 200                 205             
Leu Ser Val Thr Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu
    210                 215                 220                 
Arg Cys Arg Arg Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn
225                 230                 235                 240 
Lys Ser Leu Gly Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu
                245                 250                 255     
Asn Ser Ala Pro Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr
            260                 265                 270         
Thr Leu Arg Ile Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln
        275                 280                 285             
Tyr Glu Arg Asp Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp
    290                 295                 300                 
Phe Lys Trp Leu Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser
305                 310                 315                 320 
Asp Gly Phe Trp Lys Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro
                325                 330                 335     
Glu Ile Arg Ile Leu Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr
            340                 345                 350         
Leu Ile Gly Leu Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile
        355                 360                 365             
Pro Thr Leu Gly Ser Val Ala Val Thr Met Ala Leu His Gly Cys Asp
    370                 375                 380                 
Glu Val Ala Val Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala
385                 390                 395                 400 
Pro Leu His Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser
                405                 410                 415     
Trp Thr His Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val
            420                 425                 430         
Lys Ala Arg Val Ile Thr Asp Leu Ser Ser Gly Ile
        435                 440                 


<210> 6908
<211> 189
<212> PRT
<213> Homo sapiens

<400> 6908
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser
        35                  40                  45              
Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu
    50                  55                  60                  
Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn
65                  70                  75                  80  
Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr
                85                  90                  95      
Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp
            100                 105                 110         
Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly
        115                 120                 125             
Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys
    130                 135                 140                 
Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys
145                 150                 155                 160 
Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser
                165                 170                 175     
Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Pro Arg Leu
            180                 185                 


<210> 6909
<211> 429
<212> PRT
<213> Homo sapiens

<400> 6909
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser
        35                  40                  45              
Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu
    50                  55                  60                  
Asn Leu Asp Ser Lys Leu Ser Pro Arg Thr Leu Cys Thr Val Val Phe
65                  70                  75                  80  
Gly Leu Asp Cys Ile Leu Glu Ser Pro Gly Glu Pro Lys Lys Leu Leu
                85                  90                  95      
Met Pro Ala Ser His Pro Leu Glu Ile Leu Lys Ser Leu Ser Glu Asp
            100                 105                 110         
Thr Ala Phe Ala Leu Gly Phe Leu Lys Leu Pro Arg Pro Ala Glu Leu
        115                 120                 125             
Ala Thr Lys Tyr Ala Asn Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr
    130                 135                 140                 
Ala Ser Ala Leu Met Thr Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala
145                 150                 155                 160 
Pro Met Phe Leu Asp Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu
                165                 170                 175     
Phe Val Pro Pro Phe Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala
            180                 185                 190         
Ile Leu Ser Val Thr Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser
        195                 200                 205             
Leu Arg Cys Arg Arg Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala
    210                 215                 220                 
Asn Lys Ser Leu Gly Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg
225                 230                 235                 240 
Leu Asn Ser Ala Pro Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys
                245                 250                 255     
Thr Thr Leu Arg Ile Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu
            260                 265                 270         
Gln Tyr Glu Arg Asp Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln
        275                 280                 285             
Asp Phe Lys Trp Leu Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala
    290                 295                 300                 
Ser Asp Gly Phe Trp Lys Ser Val Ala Thr Arg Val Pro Lys Glu Pro
305                 310                 315                 320 
Pro Glu Ile Arg Ile Leu Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe
                325                 330                 335     
Thr Leu Ile Gly Leu Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn
            340                 345                 350         
Ile Pro Thr Leu Gly Ser Val Ala Val Thr Met Ala Leu His Gly Cys
        355                 360                 365             
Asp Glu Val Ala Val Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn
    370                 375                 380                 
Ala Pro Leu His Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu
385                 390                 395                 400 
Ser Trp Thr His Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu
                405                 410                 415     
Val Lys Ala Arg Val Ile Thr Asp Leu Ser Ser Gly Ile
            420                 425                 


<210> 6910
<211> 359
<212> PRT
<213> Homo sapiens

<400> 6910
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Lys Tyr Asp Arg Leu Gly Phe Leu Leu
        35                  40                  45              
Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn
    50                  55                  60                  
Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr
65                  70                  75                  80  
Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp
                85                  90                  95      
Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly
            100                 105                 110         
Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys
        115                 120                 125             
Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys
    130                 135                 140                 
Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser
145                 150                 155                 160 
Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val
                165                 170                 175     
Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr
            180                 185                 190         
Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser
        195                 200                 205             
Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys
    210                 215                 220                 
Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp Lys
225                 230                 235                 240 
Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile Leu
                245                 250                 255     
Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu Pro
            260                 265                 270         
Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly Ser
        275                 280                 285             
Val Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val Ala
    290                 295                 300                 
Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr Tyr
305                 310                 315                 320 
Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn Ile
                325                 330                 335     
Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile
            340                 345                 350         
Thr Asp Leu Ser Ser Gly Ile
        355                 


<210> 6911
<211> 201
<212> PRT
<213> Homo sapiens

<400> 6911
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Ser Lys Tyr Ser His Ser Ser Ser Pro
        35                  40                  45              
Gln Glu Lys Pro Val Ala Glu Tyr Asp Arg Leu Gly Phe Leu Leu Asn
    50                  55                  60                  
Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn Phe
65                  70                  75                  80  
Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr Ala
                85                  90                  95      
Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp Ser
            100                 105                 110         
Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly Ile
        115                 120                 125             
Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys Glu
    130                 135                 140                 
Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys Ile
145                 150                 155                 160 
Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser Arg
                165                 170                 175     
Ile Asp Asp Tyr Asp Ile Val Val Ser Pro Gly Arg Thr Ile Ser Ser
            180                 185                 190         
Glu Arg Lys Ser Phe Cys Gly Ser Trp
        195                 200     


<210> 6912
<211> 375
<212> PRT
<213> Homo sapiens

<400> 6912
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser
        35                  40                  45              
Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu
    50                  55                  60                  
Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn
65                  70                  75                  80  
Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr
                85                  90                  95      
Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp
            100                 105                 110         
Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly
        115                 120                 125             
Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys
    130                 135                 140                 
Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys
145                 150                 155                 160 
Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser
                165                 170                 175     
Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val
            180                 185                 190         
Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr
        195                 200                 205             
Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser
    210                 215                 220                 
Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys
225                 230                 235                 240 
Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp Lys
                245                 250                 255     
Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile Leu
            260                 265                 270         
Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu Pro
        275                 280                 285             
Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly Ser
    290                 295                 300                 
Val Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val Ala
305                 310                 315                 320 
Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr Tyr
                325                 330                 335     
Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn Ile
            340                 345                 350         
Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile
        355                 360                 365             
Thr Asp Leu Ser Ser Gly Ile
    370                 375 


<210> 6913
<211> 413
<212> PRT
<213> Homo sapiens

<400> 6913
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Lys Tyr Asp Arg Leu Gly Phe Leu Leu
        35                  40                  45              
Asn Leu Asp Ser Lys Leu Ser Pro Arg Thr Leu Cys Thr Val Val Phe
    50                  55                  60                  
Gly Leu Asp Cys Ile Leu Glu Ser Pro Gly Glu Pro Lys Lys Leu Leu
65                  70                  75                  80  
Met Pro Ala Ser His Pro Leu Glu Ile Leu Lys Ser Leu Ser Glu Asp
                85                  90                  95      
Thr Ala Phe Ala Leu Gly Phe Leu Lys Leu Pro Arg Pro Ala Glu Leu
            100                 105                 110         
Ala Thr Lys Tyr Ala Asn Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr
        115                 120                 125             
Ala Ser Ala Leu Met Thr Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala
    130                 135                 140                 
Pro Met Phe Leu Asp Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu
145                 150                 155                 160 
Phe Val Pro Pro Phe Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala
                165                 170                 175     
Ile Leu Ser Val Thr Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser
            180                 185                 190         
Leu Arg Cys Arg Arg Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala
        195                 200                 205             
Asn Lys Ser Leu Gly Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg
    210                 215                 220                 
Leu Asn Ser Ala Pro Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys
225                 230                 235                 240 
Thr Thr Leu Arg Ile Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu
                245                 250                 255     
Gln Tyr Glu Arg Asp Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln
            260                 265                 270         
Asp Phe Lys Trp Leu Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala
        275                 280                 285             
Ser Asp Gly Phe Trp Lys Ser Val Ala Thr Arg Val Pro Lys Glu Pro
    290                 295                 300                 
Pro Glu Ile Arg Ile Leu Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe
305                 310                 315                 320 
Thr Leu Ile Gly Leu Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn
                325                 330                 335     
Ile Pro Thr Leu Gly Ser Val Ala Val Thr Met Ala Leu His Gly Cys
            340                 345                 350         
Asp Glu Val Ala Val Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn
        355                 360                 365             
Ala Pro Leu His Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu
    370                 375                 380                 
Ser Trp Thr His Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu
385                 390                 395                 400 
Val Lys Ala Arg Val Ile Thr Asp Leu Ser Ser Gly Ile
                405                 410             


<210> 6914
<211> 344
<212> PRT
<213> Homo sapiens

<400> 6914
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser
        35                  40                  45              
Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu
    50                  55                  60                  
Asn Leu Asp Ser Lys Leu Phe Ser Lys Pro Ala Pro Met Phe Leu Asp
65                  70                  75                  80  
Asp Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe
                85                  90                  95      
Gly Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr
            100                 105                 110         
Lys Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg
        115                 120                 125             
Cys Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly
    130                 135                 140                 
Ser Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro
145                 150                 155                 160 
Val Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile
                165                 170                 175     
Thr Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp
            180                 185                 190         
Ser Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu
        195                 200                 205             
Lys Tyr Ile Val Tyr Lys Glu Arg Val Ser Ala Ser Asp Gly Phe Trp
    210                 215                 220                 
Lys Ser Val Ala Thr Arg Val Pro Lys Glu Pro Pro Glu Ile Arg Ile
225                 230                 235                 240 
Leu Asn Pro Tyr Phe Ile Gln Glu Ala Ala Phe Thr Leu Ile Gly Leu
                245                 250                 255     
Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu Gly
            260                 265                 270         
Ser Val Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala Val
        275                 280                 285             
Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His Tyr
    290                 295                 300                 
Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His Asn
305                 310                 315                 320 
Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val
                325                 330                 335     
Ile Thr Asp Leu Ser Ser Gly Ile
            340                 


<210> 6915
<211> 277
<212> PRT
<213> Homo sapiens

<400> 6915
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser
        35                  40                  45              
Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu
    50                  55                  60                  
Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn
65                  70                  75                  80  
Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr
                85                  90                  95      
Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp
            100                 105                 110         
Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly
        115                 120                 125             
Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys
    130                 135                 140                 
Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys
145                 150                 155                 160 
Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser
                165                 170                 175     
Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val
            180                 185                 190         
Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr
        195                 200                 205             
Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser
    210                 215                 220                 
Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys
225                 230                 235                 240 
Tyr Ile Val Tyr Lys Glu Arg Val Ser Trp Thr His Asn Ile Gln Arg
                245                 250                 255     
Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg Val Ile Thr Asp
            260                 265                 270         
Leu Ser Ser Gly Ile
        275         


<210> 6916
<211> 345
<212> PRT
<213> Homo sapiens

<400> 6916
Met Gly Leu Leu Val Phe Val Arg Asn Leu Leu Leu Ala Leu Cys Leu
 1               5                  10                  15      
Phe Leu Val Leu Gly Phe Leu Tyr Tyr Ser Ala Trp Lys Leu His Leu
            20                  25                  30          
Leu Gln Trp Glu Glu Asp Ser Asn Ser Val Val Leu Ser Phe Asp Ser
        35                  40                  45              
Ala Gly Gln Thr Leu Gly Ser Glu Tyr Asp Arg Leu Gly Phe Leu Leu
    50                  55                  60                  
Asn Leu Asp Ser Lys Leu Pro Ala Glu Leu Ala Thr Lys Tyr Ala Asn
65                  70                  75                  80  
Phe Ser Glu Gly Ala Cys Lys Pro Gly Tyr Ala Ser Ala Leu Met Thr
                85                  90                  95      
Ala Ile Phe Pro Arg Phe Ser Lys Pro Ala Pro Met Phe Leu Asp Asp
            100                 105                 110         
Ser Phe Arg Lys Trp Ala Arg Ile Arg Glu Phe Val Pro Pro Phe Gly
        115                 120                 125             
Ile Lys Gly Gln Asp Asn Leu Ile Lys Ala Ile Leu Ser Val Thr Lys
    130                 135                 140                 
Glu Tyr Arg Leu Thr Pro Ala Leu Asp Ser Leu Arg Cys Arg Arg Cys
145                 150                 155                 160 
Ile Ile Val Gly Asn Gly Gly Val Leu Ala Asn Lys Ser Leu Gly Ser
                165                 170                 175     
Arg Ile Asp Asp Tyr Asp Ile Val Val Arg Leu Asn Ser Ala Pro Val
            180                 185                 190         
Lys Gly Phe Glu Lys Asp Val Gly Ser Lys Thr Thr Leu Arg Ile Thr
        195                 200                 205             
Tyr Pro Glu Gly Ala Met Gln Arg Pro Glu Gln Tyr Glu Arg Asp Ser
    210                 215                 220                 
Leu Phe Val Leu Ala Gly Phe Lys Trp Gln Asp Phe Lys Trp Leu Lys
225                 230                 235                 240 
Tyr Ile Val Tyr Lys Glu Arg Val Glu Ala Ala Phe Thr Leu Ile Gly
                245                 250                 255     
Leu Pro Phe Asn Asn Gly Leu Met Gly Arg Gly Asn Ile Pro Thr Leu
            260                 265                 270         
Gly Ser Val Ala Val Thr Met Ala Leu His Gly Cys Asp Glu Val Ala
        275                 280                 285             
Val Ala Gly Phe Gly Tyr Asp Met Ser Thr Pro Asn Ala Pro Leu His
    290                 295                 300                 
Tyr Tyr Glu Thr Val Arg Met Ala Ala Ile Lys Glu Ser Trp Thr His
305                 310                 315                 320 
Asn Ile Gln Arg Glu Lys Glu Phe Leu Arg Lys Leu Val Lys Ala Arg
                325                 330                 335     
Val Ile Thr Asp Leu Ser Ser Gly Ile
            340                 345 


<210> 6917
<211> 899
<212> PRT
<213> Homo sapiens

<400> 6917
Met Tyr Leu Ser Ile Cys Cys Cys Phe Leu Leu Trp Ala Pro Ala Leu
 1               5                  10                  15      
Thr Leu Lys Asn Leu Asn Tyr Ser Val Pro Glu Glu Gln Gly Ala Gly
            20                  25                  30          
Thr Val Ile Gly Asn Ile Gly Arg Asp Ala Arg Leu Gln Pro Gly Leu
        35                  40                  45              
Pro Pro Ala Glu Arg Gly Gly Gly Gly Arg Ser Lys Ser Gly Ser Tyr
    50                  55                  60                  
Arg Val Leu Glu Asn Ser Ala Pro His Leu Leu Asp Val Asp Ala Asp
65                  70                  75                  80  
Ser Gly Leu Leu Tyr Thr Lys Gln Arg Ile Asp Arg Glu Ser Leu Cys
                85                  90                  95      
Arg His Asn Ala Lys Cys Gln Leu Ser Leu Glu Val Phe Ala Asn Asp
            100                 105                 110         
Lys Glu Ile Cys Met Ile Lys Val Glu Ile Gln Asp Ile Asn Asp Asn
        115                 120                 125             
Ala Pro Ser Phe Ser Ser Asp Gln Ile Glu Met Asp Ile Ser Glu Asn
    130                 135                 140                 
Ala Ala Pro Gly Thr Arg Phe Pro Leu Thr Ser Ala His Asp Pro Asp
145                 150                 155                 160 
Ala Gly Glu Asn Gly Leu Arg Thr Tyr Leu Leu Thr Arg Asp Asp His
                165                 170                 175     
Gly Leu Phe Gly Leu Asp Val Lys Ser Arg Gly Asp Gly Thr Lys Phe
            180                 185                 190         
Pro Glu Leu Val Ile Gln Lys Ala Leu Asp Arg Glu Gln Gln Asn His
        195                 200                 205             
His Thr Leu Val Leu Thr Ala Leu Asp Gly Gly Glu Pro Pro Arg Ser
    210                 215                 220                 
Ala Thr Val Gln Ile Asn Val Lys Val Ile Asp Ser Asn Asp Asn Ser
225                 230                 235                 240 
Pro Val Phe Glu Ala Pro Ser Tyr Leu Val Glu Leu Pro Glu Asn Ala
                245                 250                 255     
Pro Leu Gly Thr Val Val Ile Asp Leu Asn Ala Thr Asp Ala Asp Glu
            260                 265                 270         
Gly Pro Asn Gly Glu Val Leu Tyr Ser Phe Ser Ser Tyr Val Pro Asp
        275                 280                 285             
Arg Val Arg Glu Leu Phe Ser Ile Asp Pro Lys Thr Gly Leu Ile Arg
    290                 295                 300                 
Val Lys Gly Asn Leu Asp Tyr Glu Glu Asn Gly Met Leu Glu Ile Asp
305                 310                 315                 320 
Val Gln Ala Arg Asp Leu Gly Pro Asn Pro Ile Pro Ala His Cys Lys
                325                 330                 335     
Val Thr Val Lys Leu Ile Asp Arg Asn Asp Asn Ala Pro Ser Ile Gly
            340                 345                 350         
Phe Val Ser Val Arg Gln Gly Ala Leu Ser Glu Ala Ala Pro Pro Gly
        355                 360                 365             
Thr Val Ile Ala Leu Val Arg Val Thr Asp Arg Asp Ser Gly Lys Asn
    370                 375                 380                 
Gly Gln Leu Gln Cys Arg Val Leu Gly Gly Gly Gly Thr Gly Gly Gly
385                 390                 395                 400 
Gly Gly Leu Gly Gly Pro Gly Gly Ser Val Pro Phe Lys Leu Glu Glu
                405                 410                 415     
Asn Tyr Asp Asn Phe Tyr Thr Val Val Thr Asp Arg Pro Leu Asp Arg
            420                 425                 430         
Glu Thr Gln Asp Glu Tyr Asn Val Thr Ile Val Ala Arg Asp Gly Gly
        435                 440                 445             
Ser Pro Pro Leu Asn Ser Thr Lys Ser Phe Ala Ile Lys Ile Leu Asp
    450                 455                 460                 
Glu Asn Asp Asn Pro Pro Arg Phe Thr Lys Gly Leu Tyr Val Leu Gln
465                 470                 475                 480 
Val His Glu Asn Asn Ile Pro Gly Glu Tyr Leu Gly Ser Val Leu Ala
                485                 490                 495     
Gln Asp Pro Asp Leu Gly Gln Asn Gly Thr Val Ser Tyr Ser Ile Leu
            500                 505                 510         
Pro Ser His Ile Gly Asp Val Ser Ile Tyr Thr Tyr Val Ser Val Asn
        515                 520                 525             
Pro Thr Asn Gly Ala Ile Tyr Ala Leu Arg Ser Phe Asn Phe Glu Gln
    530                 535                 540                 
Thr Lys Ala Phe Glu Phe Lys Val Leu Ala Lys Asp Ser Gly Ala Pro
545                 550                 555                 560 
Ala His Leu Glu Ser Asn Ala Thr Val Arg Val Thr Val Leu Asp Val
                565                 570                 575     
Asn Asp Asn Ala Pro Val Ile Val Leu Pro Thr Leu Gln Asn Asp Thr
            580                 585                 590         
Ala Glu Leu Gln Val Pro Arg Asn Ala Gly Leu Gly Tyr Leu Val Ser
        595                 600                 605             
Thr Val Arg Ala Leu Asp Ser Asp Phe Gly Glu Ser Gly Arg Leu Thr
    610                 615                 620                 
Tyr Glu Ile Val Asp Gly Asn Asp Asp His Leu Phe Glu Ile Asp Pro
625                 630                 635                 640 
Ser Ser Gly Glu Ile Arg Thr Leu His Pro Phe Trp Glu Asp Val Thr
                645                 650                 655     
Pro Val Val Glu Leu Val Val Lys Val Thr Asp His Gly Lys Pro Thr
            660                 665                 670         
Leu Ser Ala Val Ala Lys Leu Ile Ile Arg Ser Val Ser Gly Ser Leu
        675                 680                 685             
Pro Glu Gly Val Pro Arg Val Asn Gly Glu Gln His His Trp Asp Met
    690                 695                 700                 
Ser Leu Pro Leu Ile Val Thr Leu Ser Thr Ile Ser Ile Ile Leu Leu
705                 710                 715                 720 
Ala Ala Met Ile Thr Ile Ala Val Lys Cys Lys Arg Glu Asn Lys Glu
                725                 730                 735     
Ile Arg Thr Tyr Asn Cys Arg Ile Ala Glu Tyr Ser His Pro Gln Leu
            740                 745                 750         
Gly Gly Gly Lys Gly Lys Lys Lys Lys Ile Asn Lys Asn Asp Ile Met
        755                 760                 765             
Leu Val Gln Ser Glu Val Glu Glu Arg Asn Ala Met Asn Val Met Asn
    770                 775                 780                 
Val Val Ser Ser Pro Ser Leu Ala Thr Ser Pro Met Tyr Phe Asp Tyr
785                 790                 795                 800 
Gln Thr Arg Leu Pro Leu Ser Ser Pro Arg Ser Glu Val Met Tyr Leu
                805                 810                 815     
Lys Pro Ala Ser Asn Asn Leu Thr Val Pro Gln Gly His Ala Gly Cys
            820                 825                 830         
His Thr Ser Phe Thr Gly Gln Gly Thr Asn Ala Ser Glu Thr Pro Ala
        835                 840                 845             
Thr Arg Met Ser Ile Ile Gln Thr Asp Asn Phe Pro Ala Glu Pro Asn
    850                 855                 860                 
Tyr Met Gly Ser Arg Gln Gln Phe Val Gln Arg Gln His Phe Leu Phe
865                 870                 875                 880 
Phe Phe Phe Ile Cys Ile Ser Val Ala Pro Arg Leu Arg Thr Gln Lys
                885                 890                 895     
Glu Pro Ala
            


<210> 6918
<211> 472
<212> PRT
<213> Homo sapiens

<400> 6918
Met Ala Gly Ala Ser Arg Leu Leu Phe Leu Trp Leu Gly Cys Phe Cys
 1               5                  10                  15      
Val Ser Leu Ala Gln Gly Glu Arg Pro Lys Pro Pro Phe Pro Glu Leu
            20                  25                  30          
Arg Lys Ala Val Pro Gly Asp Arg Thr Ala Gly Gly Gly Pro Asp Ser
        35                  40                  45              
Glu Leu Gln Pro Gln Asp Lys Val Ser Glu His Met Leu Arg Leu Tyr
    50                  55                  60                  
Asp Arg Tyr Ser Thr Val Gln Ala Ala Arg Thr Pro Gly Ser Leu Glu
65                  70                  75                  80  
Gly Gly Ser Gln Pro Trp Arg Pro Arg Leu Leu Arg Glu Gly Asn Thr
                85                  90                  95      
Val Arg Ser Phe Arg Ala Ala Ala Ala Glu Thr Leu Glu Arg Lys Gly
            100                 105                 110         
Leu Tyr Ile Phe Asn Leu Thr Ser Leu Thr Lys Ser Glu Asn Ile Leu
        115                 120                 125             
Ser Ala Thr Leu Tyr Phe Cys Ile Gly Glu Leu Gly Asn Ile Ser Leu
    130                 135                 140                 
Ser Cys Pro Val Ser Gly Gly Cys Ser His His Ala Gln Arg Lys His
145                 150                 155                 160 
Ile Gln Ile Asp Leu Ser Ala Trp Thr Leu Lys Phe Ser Arg Asn Gln
                165                 170                 175     
Ser Gln Leu Leu Gly His Leu Ser Val Asp Met Ala Lys Ser His Arg
            180                 185                 190         
Asp Ile Met Ser Trp Leu Ser Lys Asp Ile Thr Gln Phe Leu Arg Lys
        195                 200                 205             
Ala Lys Glu Asn Glu Glu Phe Leu Ile Gly Phe Asn Ile Thr Ser Lys
    210                 215                 220                 
Gly Arg Gln Leu Pro Lys Arg Arg Leu Pro Phe Pro Glu Pro Tyr Ile
225                 230                 235                 240 
Leu Val Tyr Ala Asn Asp Ala Ala Ile Ser Glu Pro Glu Ser Val Val
                245                 250                 255     
Ser Ser Leu Gln Gly His Arg Asn Phe Pro Thr Gly Thr Val Pro Lys
            260                 265                 270         
Trp Asp Ser His Ile Arg Ala Ala Leu Ser Ile Glu Arg Arg Lys Lys
        275                 280                 285             
Arg Ser Thr Gly Val Leu Leu Pro Leu Gln Asn Asn Glu Leu Pro Gly
    290                 295                 300                 
Ala Glu Tyr Gln Tyr Lys Lys Asp Glu Val Trp Glu Glu Arg Lys Pro
305                 310                 315                 320 
Tyr Lys Thr Leu Gln Ala Gln Ala Pro Glu Lys Ser Lys Asn Lys Lys
                325                 330                 335     
Lys Gln Arg Lys Gly Pro His Arg Lys Ser Gln Thr Leu Gln Phe Asp
            340                 345                 350         
Glu Gln Thr Leu Lys Lys Ala Arg Arg Lys Gln Trp Ile Glu Pro Arg
        355                 360                 365             
Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp
    370                 375                 380                 
Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ser
385                 390                 395                 400 
Gly Ala Cys Gln Phe Pro Met Pro Lys Ser Leu Lys Pro Ser Asn His
                405                 410                 415     
Ala Thr Ile Gln Ser Ile Val Arg Ala Val Gly Val Val Pro Gly Ile
            420                 425                 430         
Pro Glu Pro Cys Cys Val Pro Glu Lys Met Ser Ser Leu Ser Ile Leu
        435                 440                 445             
Phe Phe Asp Glu Asn Lys Asn Val Val Leu Lys Val Tyr Pro Asn Met
    450                 455                 460                 
Thr Val Glu Ser Cys Ala Cys Arg
465                 470         


<210> 6919
<211> 870
<212> PRT
<213> Homo sapiens

<400> 6919
Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met
 1               5                  10                  15      
Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn
            20                  25                  30          
Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu
        35                  40                  45              
Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val
    50                  55                  60                  
Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe
65                  70                  75                  80  
Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser
                85                  90                  95      
Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser
            100                 105                 110         
Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp
        115                 120                 125             
Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser
    130                 135                 140                 
Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr
145                 150                 155                 160 
Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser
                165                 170                 175     
Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys
            180                 185                 190         
Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly
        195                 200                 205             
Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe
    210                 215                 220                 
Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr
225                 230                 235                 240 
Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala
                245                 250                 255     
Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys
            260                 265                 270         
Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu
        275                 280                 285             
Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly
    290                 295                 300                 
Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr
305                 310                 315                 320 
Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe
                325                 330                 335     
Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe
            340                 345                 350         
Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro
        355                 360                 365             
Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe
    370                 375                 380                 
Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile
385                 390                 395                 400 
Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr
                405                 410                 415     
Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp
            420                 425                 430         
Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val
        435                 440                 445             
Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Arg Thr Gly Leu Leu
    450                 455                 460                 
Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro
465                 470                 475                 480 
Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val
                485                 490                 495     
Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser
            500                 505                 510         
Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu
        515                 520                 525             
Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln
    530                 535                 540                 
Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln Ser Gln Ser His
545                 550                 555                 560 
Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro
                565                 570                 575     
Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys
            580                 585                 590         
Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu
        595                 600                 605             
Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu
    610                 615                 620                 
Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Arg Ile Leu
625                 630                 635                 640 
Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr
                645                 650                 655     
Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn
            660                 665                 670         
Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu
        675                 680                 685             
Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly
    690                 695                 700                 
Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu
705                 710                 715                 720 
Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala
                725                 730                 735     
Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln
            740                 745                 750         
Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys
        755                 760                 765             
Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys
    770                 775                 780                 
Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly
785                 790                 795                 800 
Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln
                805                 810                 815     
His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg
            820                 825                 830         
Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn
        835                 840                 845             
Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro
    850                 855                 860                 
Ser His Ser Pro Lys Thr
865                 870 


<210> 6920
<211> 870
<212> PRT
<213> Homo sapiens

<400> 6920
Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met
 1               5                  10                  15      
Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn
            20                  25                  30          
Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu
        35                  40                  45              
Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val
    50                  55                  60                  
Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe
65                  70                  75                  80  
Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser
                85                  90                  95      
Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser
            100                 105                 110         
Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp
        115                 120                 125             
Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser
    130                 135                 140                 
Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr
145                 150                 155                 160 
Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser
                165                 170                 175     
Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys
            180                 185                 190         
Trp Glu Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly
        195                 200                 205             
Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe
    210                 215                 220                 
Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr
225                 230                 235                 240 
Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala
                245                 250                 255     
Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys
            260                 265                 270         
Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu
        275                 280                 285             
Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly
    290                 295                 300                 
Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr
305                 310                 315                 320 
Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe
                325                 330                 335     
Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe
            340                 345                 350         
Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro
        355                 360                 365             
Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe
    370                 375                 380                 
Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ile Trp Ser Leu Ala Ile
385                 390                 395                 400 
Leu Leu Leu Ser Lys Lys Tyr Lys Gln Leu Pro His Met Leu Thr Thr
                405                 410                 415     
Asn Leu Leu Ile Ala Gln Ser Ile Val Cys Ala Gly Met Met Ile Trp
            420                 425                 430         
Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile Leu Val Phe Val
        435                 440                 445             
Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp Thr Gly Leu Leu
    450                 455                 460                 
Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg Val Gln Ile Pro
465                 470                 475                 480 
Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro Ala Leu Leu Val
                485                 490                 495     
Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp Ser Ile Asp Ser
            500                 505                 510         
Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr Ala Val Thr Leu
        515                 520                 525             
Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met Cys Met Asn Gln
    530                 535                 540                 
Thr Ala Gln Ala Gly Gly Tyr Glu Gly Phe Asp Gln Ser Gln Ser His
545                 550                 555                 560 
Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu Ser Pro Ala Pro
                565                 570                 575     
Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro Glu Thr Ser Cys
            580                 585                 590         
Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys Pro Ser Ile Glu
        595                 600                 605             
Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile Pro Ser Phe Glu
    610                 615                 620                 
Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln Ser Cys Ile Leu
625                 630                 635                 640 
Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp Gln Gln Leu Thr
                645                 650                 655     
Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly Leu Phe Ala Asn
            660                 665                 670         
Leu Tyr Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu Pro Gly Arg Leu
        675                 680                 685             
Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn Phe Gly Gln Gly
    690                 695                 700                 
Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His Leu Ile Ile Leu
705                 710                 715                 720 
Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn Lys Asp Thr Ala
                725                 730                 735     
Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys Met Thr Cys Gln
            740                 745                 750         
Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg Asn Ile Val Lys
        755                 760                 765             
Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr Phe Cys Gly Cys
    770                 775                 780                 
Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala Ser Asp Arg Gly
785                 790                 795                 800 
Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly Gly Val Ile Gln
                805                 810                 815     
His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr Leu Phe Tyr Arg
            820                 825                 830         
Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala Ile Asn Ala Asn
        835                 840                 845             
Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His Ser Ser Pro Pro
    850                 855                 860                 
Ser His Ser Pro Lys Thr
865                 870 


<210> 6921
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6921
Met Val Ile Gln Lys Glu Lys Lys Ser Cys Gly Gln Val Val Glu Glu
 1               5                  10                  15      
Trp Lys Glu Phe Val Trp Asn Pro Arg Thr His Gln Phe Met Gly Arg
            20                  25                  30          
Thr Gly Thr Ser Trp Ala Phe Ile Leu Leu Phe Tyr Leu Val Phe Tyr
        35                  40                  45              
Gly Phe Pro Thr Ala Met Phe Thr Leu Thr Met Trp Val Met Leu Gln
    50                  55                  60                  
Thr Val Ser Asp His Thr Pro Lys Tyr Gln Asp Arg Leu Ala Thr Pro
65                  70                  75                  80  
Gly Leu Met Ile Arg Pro Lys Thr Glu Asn Leu Asp Val Ile Val Asn
                85                  90                  95      
Val Ser Asp Thr Glu Ser Trp Asp Gln His Val Gln Lys Leu Asn Lys
            100                 105                 110         
Phe Leu Glu Pro Tyr Asn Asp Ser Met Gln Ala Gln Lys Asn Asp Val
        115                 120                 125             
Cys Arg Pro Gly Arg Tyr Tyr Glu Gln Pro Asp Asn Gly Val Leu Asn
    130                 135                 140                 
Tyr Pro Lys Leu Ala Cys Gln Phe Asn Arg Thr Gln Leu Gly Asn Cys
145                 150                 155                 160 
Ser Gly Ile Gly Asp Ser Thr His Tyr Gly Tyr Ser Thr Gly Gln Pro
                165                 170                 175     
Cys Val Phe Ile Lys Met Asn Arg Val Ile Asn Phe Tyr Ala Gly Ala
            180                 185                 190         
Asn Gln Ser Met Asn Val Thr Cys Ala Gly Lys Arg Asp Glu Asp Ala
        195                 200                 205             
Glu Asn Leu Gly Asn Phe Val Met Phe Pro Ala Asn Gly Asn Ile Asp
    210                 215                 220                 
Leu Met Tyr Phe Pro Tyr Tyr Gly Lys Lys Phe His Val Asn Tyr Thr
225                 230                 235                 240 
Gln Pro Leu Val Ala Val Lys Phe Leu Asn Val Thr Pro Asn Val Glu
                245                 250                 255     
Val Asn Val Glu Cys Arg Ile Asn Ala Ala Asn Ile Ala Thr Asp Asp
            260                 265                 270         
Glu Arg Asp Lys Phe Ala Gly Arg Val Ala Phe Lys Leu Arg Ile Asn
        275                 280                 285             
Lys Thr
    290 


<210> 6922
<211> 791
<212> PRT
<213> Homo sapiens

<400> 6922
Met Ala Asp Asp Lys Val Ala Ile Leu Thr Asp Asp Glu Glu Glu Gln
 1               5                  10                  15      
Lys Arg Lys Tyr Val Leu Ala Asp Pro Phe Asn Gly Ile Ser Arg Glu
            20                  25                  30          
Pro Glu Pro Pro Ser Asn Glu Thr Pro Ser Ser Thr Glu Thr Ser Ala
        35                  40                  45              
Ile Pro Glu Glu Glu Ile Asp Trp Ile Glu Lys His Cys Val Lys Ile
    50                  55                  60                  
Asn Asn Asp Leu Leu Ile Ser Lys Val Phe Tyr Phe Phe Phe Tyr Ser
65                  70                  75                  80  
Ala Tyr Gly Ser Leu Tyr Pro Leu Leu Pro Val Tyr Tyr Lys Gln Leu
                85                  90                  95      
Gly Met Ser Pro Ser Gln Ser Gly Leu Leu Val Gly Ile Arg Tyr Phe
            100                 105                 110         
Ile Glu Phe Cys Ser Ala Pro Phe Trp Gly Val Val Ala Asp Arg Phe
        115                 120                 125             
Lys Lys Gly Lys Ile Val Leu Leu Phe Ser Leu Leu Cys Trp Val Leu
    130                 135                 140                 
Phe Asn Leu Gly Ile Gly Phe Val Lys Pro Ala Thr Leu Arg Cys Val
145                 150                 155                 160 
Pro Lys Ile Arg Pro Thr Thr His Pro Thr Asn Ala Ser His Gln Leu
                165                 170                 175     
Thr Ile Leu Pro Thr Asn Ser Ser Phe Thr Ser Phe Leu Thr Ile Ser
            180                 185                 190         
Pro Lys Met Arg Glu Lys Arg Asn Leu Leu Glu Thr Gly Leu Asn Val
        195                 200                 205             
Ser Asp Thr Val Thr Leu Pro Thr Ala Pro Asn Met Asn Ser Glu Pro
    210                 215                 220                 
Thr Leu Gln Pro Gln Thr Gly Glu Ile Thr Asn Arg Met Met Asp Leu
225                 230                 235                 240 
Thr Leu Asn Ser Ser Thr Ala Thr Pro Val Ser Pro Gly Ser Val Thr
                245                 250                 255     
Lys Glu Thr Thr Thr Val Ile Val Thr Thr Thr Lys Ser Leu Pro Ser
            260                 265                 270         
Asp Gln Val Met Leu Val Tyr Asp Gln Gln Glu Val Glu Ala Ile Phe
        275                 280                 285             
Leu Val Ile Leu Val Val Val Ile Ile Gly Glu Phe Phe Ser Ala Ser
    290                 295                 300                 
Ser Val Thr Ile Val Asp Thr Val Thr Leu Gln Tyr Leu Gly Lys His
305                 310                 315                 320 
Arg Asp Arg Tyr Gly Leu Gln Arg Met Trp Gly Ser Leu Gly Trp Gly
                325                 330                 335     
Leu Ala Met Leu Ser Val Gly Ile Gly Ile Asp Tyr Thr His Ile Glu
            340                 345                 350         
Val Leu Ile Asp Gly Lys Gly Cys Lys Pro Pro Glu Tyr Arg Asn Tyr
        355                 360                 365             
Gln Ile Val Phe Ile Val Phe Gly Val Leu Met Thr Met Ala Leu Ile
    370                 375                 380                 
Val Ala Thr Gln Phe Arg Phe Arg Tyr Asn His Phe Lys Asn Asp Asp
385                 390                 395                 400 
Ser Lys Gly Lys Glu Val Glu Ile Pro Gln Val Glu Arg Asn Asn Ser
                405                 410                 415     
Thr Glu Ser Ser Glu Glu Thr Pro Thr Thr Thr Ser His Ser Gln Ala
            420                 425                 430         
Phe Asn Phe Trp Asp Leu Ile Lys Leu Leu Cys Ser Val Gln Tyr Gly
        435                 440                 445             
Ser Val Leu Phe Val Ala Trp Phe Met Gly Phe Gly Tyr Gly Phe Val
    450                 455                 460                 
Phe Thr Phe Leu Tyr Trp His Leu Glu Asp Leu Asn Gly Thr Thr Thr
465                 470                 475                 480 
Leu Phe Gly Val Cys Ser Val Leu Ser His Val Ser Glu Leu Thr Ala
                485                 490                 495     
Tyr Phe Phe Ser His Lys Leu Ile Glu Leu Ile Gly His Ile Arg Val
            500                 505                 510         
Leu Tyr Ile Gly Leu Ala Cys Asn Thr Ala Arg Tyr Ile Tyr Ile Ser
        515                 520                 525             
Tyr Leu Glu Asn Ala Trp Thr Val Leu Pro Met Glu Val Leu Gln Gly
    530                 535                 540                 
Val Thr His Ala Ala Ile Trp Ala Ala Cys Ile Ser Tyr Leu Ser Ala
545                 550                 555                 560 
Ala Val Pro Pro Glu Leu Arg Thr Ser Ala Gln Gly Ile Leu Gln Gly
                565                 570                 575     
Leu His Leu Gly Leu Gly Arg Gly Cys Gly Ala Met Ile Gly Gly Val
            580                 585                 590         
Leu Val Asn Tyr Phe Gly Ala Ala Ala Thr Phe Arg Gly Ile Gly Met
        595                 600                 605             
Ala Cys Leu Val Ile Leu Leu Leu Phe Ala Leu Ile Gln Trp Leu Ala
    610                 615                 620                 
Val Pro Asp Glu Glu Glu Asp Lys Thr Met Leu Ala Glu Arg Ile Pro
625                 630                 635                 640 
Val Pro Ser Ser Pro Val Pro Ile Ala Thr Ile Asp Leu Val Gln Gln
                645                 650                 655     
Gln Thr Glu Asp Val Met Pro Arg Ile Glu Pro Arg Leu Pro Pro Lys
            660                 665                 670         
Lys Thr Lys His Gln Glu Glu Gln Glu Asp Val Asn Lys Pro Ala Trp
        675                 680                 685             
Gly Val Ser Ser Ser Pro Trp Val Thr Phe Val Tyr Ala Leu Tyr Gln
    690                 695                 700                 
Ile Lys Glu Met Met Gln Leu Thr Arg Asp Asn Arg Ala Ser Glu Ile
705                 710                 715                 720 
Gln Pro Leu Gln Gly Thr Asn Glu Asn Arg Glu Asn Ser Pro Ala Gly
                725                 730                 735     
Arg Ala Gln Pro Val Pro Cys Glu Thr His Ser Asp Pro Ser Arg Asn
            740                 745                 750         
Gln Pro Ser Pro Asp Ala Ala Ala Ser Gln Thr Gln Thr Ser Pro Ala
        755                 760                 765             
His Pro Ser Val Asp Pro Cys Thr Glu Glu Ser Glu Glu Gln Gln Ala
    770                 775                 780                 
Gln Leu Ala Ala Gly Gly His
785                 790     


<210> 6923
<211> 162
<212> PRT
<213> Homo sapiens

<400> 6923
Met Ala Ile His Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe
 1               5                  10                  15      
Leu Phe Pro Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg Gly
            20                  25                  30          
Val Gly Tyr Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met Phe
        35                  40                  45              
Val Glu Asn Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys Arg
    50                  55                  60                  
Pro Val Ser Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser Val
65                  70                  75                  80  
Tyr Gln Pro Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu Gly
                85                  90                  95      
Ala Tyr Asp Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val Met
            100                 105                 110         
Gly Ser Ala Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala Gln
        115                 120                 125             
Ser His Gln Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln Val
    130                 135                 140                 
Ser Glu Leu Thr Gln Arg Gly Gln Ala Asn Thr Asn Gln Val Phe Leu
145                 150                 155                 160 
Arg Leu
        


<210> 6924
<211> 441
<212> PRT
<213> Homo sapiens

<400> 6924
Met Ala Ile His Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe
 1               5                  10                  15      
Leu Phe Pro Gly Ala Trp Ala Gln Gly His Val Pro Pro Gly Cys Ser
            20                  25                  30          
Gln Gly Leu Asn Pro Leu Tyr Tyr Asn Leu Cys Asp Arg Ser Gly Ala
        35                  40                  45              
Trp Gly Ile Val Leu Glu Ala Val Ala Gly Ala Gly Ile Val Thr Thr
    50                  55                  60                  
Phe Val Leu Thr Ile Ile Leu Val Ala Ser Leu Pro Phe Val Gln Asp
65                  70                  75                  80  
Thr Lys Lys Arg Ser Leu Leu Gly Thr Gln Val Phe Phe Leu Leu Gly
                85                  90                  95      
Thr Leu Gly Leu Phe Cys Leu Val Phe Ala Cys Val Val Lys Pro Asp
            100                 105                 110         
Phe Ser Thr Cys Ala Ser Arg Arg Phe Leu Phe Gly Val Leu Phe Ala
        115                 120                 125             
Ile Cys Phe Ser Cys Leu Ala Ala His Val Phe Ala Leu Asn Phe Leu
    130                 135                 140                 
Ala Arg Lys Asn His Gly Pro Arg Gly Trp Val Ile Phe Thr Val Ala
145                 150                 155                 160 
Leu Leu Leu Thr Leu Val Glu Val Ile Ile Asn Thr Glu Trp Leu Ile
                165                 170                 175     
Ile Thr Leu Val Arg Gly Ser Gly Glu Gly Gly Pro Gln Gly Asn Ser
            180                 185                 190         
Ser Ala Gly Trp Ala Val Ala Ser Pro Cys Ala Ile Ala Asn Met Asp
        195                 200                 205             
Phe Val Met Ala Leu Ile Tyr Val Met Leu Leu Leu Leu Gly Ala Phe
    210                 215                 220                 
Leu Gly Ala Trp Pro Ala Leu Cys Gly Arg Tyr Lys Arg Trp Arg Lys
225                 230                 235                 240 
His Gly Val Phe Val Leu Leu Thr Thr Ala Thr Ser Val Ala Ile Trp
                245                 250                 255     
Val Val Trp Ile Val Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser
            260                 265                 270         
Pro Thr Trp Asp Asp Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala
        275                 280                 285             
Trp Ala Phe Val Leu Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr
    290                 295                 300                 
Lys Ser Ser Pro Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg
305                 310                 315                 320 
Gly Val Gly Tyr Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met
                325                 330                 335     
Phe Val Glu Asn Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys
            340                 345                 350         
Arg Pro Val Ser Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser
        355                 360                 365             
Val Tyr Gln Pro Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu
    370                 375                 380                 
Gly Ala Tyr Asp Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val
385                 390                 395                 400 
Met Gly Ser Ala Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala
                405                 410                 415     
Gln Ser His Gln Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln
            420                 425                 430         
Val Phe Arg Asn Pro Tyr Val Trp Asp
        435                 440     


<210> 6925
<211> 486
<212> PRT
<213> Homo sapiens

<400> 6925
Met Arg Gly Arg Gly Ser Gln Gln Gln Gln Pro Thr Arg Arg Gln Gly
 1               5                  10                  15      
Gln Lys Leu Pro Ser Pro Ser Pro Ala Gly Lys Tyr Glu Ser Ala Gln
            20                  25                  30          
Pro Gly Gly Thr Gln Pro Glu Pro Gly Leu Gly Ala Arg Met Ala Ile
        35                  40                  45              
His Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe Leu Phe Pro
    50                  55                  60                  
Gly Ala Trp Ala Gln Gly His Val Pro Pro Gly Cys Ser Gln Gly Leu
65                  70                  75                  80  
Asn Pro Leu Tyr Tyr Asn Leu Cys Asp Arg Ser Gly Ala Trp Gly Ile
                85                  90                  95      
Val Leu Glu Ala Val Ala Gly Ala Gly Ile Val Thr Thr Phe Val Leu
            100                 105                 110         
Thr Ile Ile Leu Val Ala Ser Leu Pro Phe Val Gln Asp Thr Lys Lys
        115                 120                 125             
Arg Ser Leu Leu Gly Thr Gln Val Phe Phe Leu Leu Gly Thr Leu Gly
    130                 135                 140                 
Leu Phe Cys Leu Val Phe Ala Cys Val Val Lys Pro Asp Phe Ser Thr
145                 150                 155                 160 
Cys Ala Ser Arg Arg Phe Leu Phe Gly Val Leu Phe Ala Ile Cys Phe
                165                 170                 175     
Ser Cys Leu Ala Ala His Val Phe Ala Leu Asn Phe Leu Ala Arg Lys
            180                 185                 190         
Asn His Gly Pro Arg Gly Trp Val Ile Phe Thr Val Ala Leu Leu Leu
        195                 200                 205             
Thr Leu Val Glu Val Ile Ile Asn Thr Glu Trp Leu Ile Ile Thr Leu
    210                 215                 220                 
Val Arg Gly Ser Gly Glu Gly Gly Pro Gln Gly Asn Ser Ser Ala Gly
225                 230                 235                 240 
Trp Ala Val Ala Ser Pro Cys Ala Ile Ala Asn Met Asp Phe Val Met
                245                 250                 255     
Ala Leu Ile Tyr Val Met Leu Leu Leu Leu Gly Ala Phe Leu Gly Ala
            260                 265                 270         
Trp Pro Ala Leu Cys Gly Arg Tyr Lys Arg Trp Arg Lys His Gly Val
        275                 280                 285             
Phe Val Leu Leu Thr Thr Ala Thr Ser Val Ala Ile Trp Val Val Trp
    290                 295                 300                 
Ile Val Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser Pro Thr Trp
305                 310                 315                 320 
Asp Asp Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala Trp Ala Phe
                325                 330                 335     
Val Leu Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr Lys Ser Ser
            340                 345                 350         
Pro Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg Gly Val Gly
        355                 360                 365             
Tyr Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met Phe Val Glu
    370                 375                 380                 
Asn Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys Arg Pro Val
385                 390                 395                 400 
Ser Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser Val Tyr Gln
                405                 410                 415     
Pro Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu Gly Ala Tyr
            420                 425                 430         
Asp Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val Met Gly Ser
        435                 440                 445             
Ala Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala Gln Ser His
    450                 455                 460                 
Gln Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln Val Phe Arg
465                 470                 475                 480 
Asn Pro Tyr Val Trp Asp
                485     


<210> 6926
<211> 828
<212> PRT
<213> Homo sapiens

<400> 6926
Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp
 1               5                  10                  15      
Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser
            20                  25                  30          
Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val
        35                  40                  45              
Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn
    50                  55                  60                  
Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn
65                  70                  75                  80  
Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val
                85                  90                  95      
Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val
            100                 105                 110         
Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro
        115                 120                 125             
Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr
    130                 135                 140                 
Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu
145                 150                 155                 160 
Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys
                165                 170                 175     
Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His
            180                 185                 190         
Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu
        195                 200                 205             
Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser
    210                 215                 220                 
Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu
225                 230                 235                 240 
Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu
                245                 250                 255     
Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg
            260                 265                 270         
Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg
        275                 280                 285             
Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro
    290                 295                 300                 
Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly
305                 310                 315                 320 
Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile
                325                 330                 335     
Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys
            340                 345                 350         
Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys
        355                 360                 365             
His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser
    370                 375                 380                 
Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr
385                 390                 395                 400 
Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly
                405                 410                 415     
Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp
            420                 425                 430         
Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr
        435                 440                 445             
Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro
    450                 455                 460                 
Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu
465                 470                 475                 480 
Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe
                485                 490                 495     
Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met
            500                 505                 510         
Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu
        515                 520                 525             
Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr
    530                 535                 540                 
Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala
545                 550                 555                 560 
Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe
                565                 570                 575     
Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe
            580                 585                 590         
Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser
        595                 600                 605             
Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr
    610                 615                 620                 
Gln Leu Ile Ala Arg Arg Ala Ala Asp Asn Leu Arg Arg His His Gln
625                 630                 635                 640 
Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala Met
                645                 650                 655     
Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe Lys
            660                 665                 670         
Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly Leu
        675                 680                 685             
Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser Lys
    690                 695                 700                 
Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu Glu
705                 710                 715                 720 
Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu Glu Arg Asn Ile Gln
                725                 730                 735     
Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp Leu Ser Ile Pro Gly
            740                 745                 750         
Leu Ser Glu Gln Cys Val Leu Val Asp His Arg Glu Arg Asn Thr Asp
        755                 760                 765             
Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys Pro Phe Lys Ser Glu
    770                 775                 780                 
Lys Val Val Val Glu Asp Thr Val Pro Ile Ile Pro Lys Glu Lys His
785                 790                 795                 800 
Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp Leu Asn Leu Pro Asp
                805                 810                 815     
Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg Leu
            820                 825             


<210> 6927
<211> 301
<212> PRT
<213> Homo sapiens

<400> 6927
Met Glu Arg Ala Pro Pro Asp Gly Pro Leu Asn Ala Ser Gly Ala Leu
 1               5                  10                  15      
Ala Gly Asp Ala Ala Ala Ala Gly Gly Ala Arg Gly Phe Ser Ala Ala
            20                  25                  30          
Trp Thr Ala Val Leu Ala Ala Leu Met Ala Leu Leu Ile Val Ala Thr
        35                  40                  45              
Val Leu Gly Asn Ala Leu Val Met Leu Ala Phe Val Ala Asp Ser Ser
    50                  55                  60                  
Leu Arg Thr Gln Asn Asn Phe Phe Leu Leu Asn Leu Ala Ile Ser Asp
65                  70                  75                  80  
Phe Leu Val Gly Ala Phe Cys Ile Pro Leu Tyr Val Pro Tyr Val Leu
                85                  90                  95      
Thr Gly Arg Trp Thr Phe Gly Arg Gly Leu Cys Lys Leu Trp Leu Val
            100                 105                 110         
Val Asp Tyr Leu Leu Cys Thr Ser Ser Ala Phe Asn Ile Val Leu Ile
        115                 120                 125             
Ser Tyr Asp Arg Phe Leu Ser Val Thr Arg Ala Val Ser Tyr Arg Ala
    130                 135                 140                 
Gln Gln Gly Asp Thr Arg Arg Ala Val Arg Lys Met Leu Leu Val Trp
145                 150                 155                 160 
Val Leu Ala Phe Leu Leu Tyr Gly Pro Ala Ile Leu Ser Trp Glu Tyr
                165                 170                 175     
Leu Ser Gly Gly Ser Ser Ile Pro Glu Gly His Cys Tyr Ala Glu Phe
            180                 185                 190         
Phe Tyr Asn Trp Tyr Phe Leu Ile Thr Ala Ser Thr Leu Glu Phe Phe
        195                 200                 205             
Thr Pro Phe Leu Ser Val Thr Phe Phe Asn Leu Ser Ile Tyr Leu Asn
    210                 215                 220                 
Ile Gln Arg Arg Thr Arg Leu Arg Leu Asp Gly Ala Arg Glu Ala Ala
225                 230                 235                 240 
Gly Pro Glu Pro Pro Pro Glu Ala Gln Pro Ser Pro Pro Pro Pro Pro
                245                 250                 255     
Gly Cys Trp Gly Cys Trp Gln Lys Gly His Gly Glu Ala Met Pro Leu
            260                 265                 270         
His Ser Phe Arg Arg Ala Phe Thr Lys Leu Leu Cys Pro Gln Lys Leu
        275                 280                 285             
Lys Ile Gln Pro His Ser Ser Leu Glu His Cys Trp Lys
    290                 295                 300     


<210> 6928
<211> 200
<212> PRT
<213> Homo sapiens

<400> 6928
Met Glu Arg Ala Pro Pro Asp Gly Pro Leu Asn Ala Ser Gly Ala Leu
 1               5                  10                  15      
Ala Gly Asp Ala Ala Ala Ala Gly Gly Ala Arg Gly Phe Ser Ala Ala
            20                  25                  30          
Trp Thr Ala Val Leu Ala Ala Leu Met Ala Leu Leu Ile Val Ala Thr
        35                  40                  45              
Val Leu Gly Asn Ala Leu Val Met Leu Ala Phe Val Ala Asp Ser Ser
    50                  55                  60                  
Leu Arg Thr Gln Asn Asn Phe Phe Leu Leu Asn Leu Ala Ile Ser Asp
65                  70                  75                  80  
Phe Leu Val Gly Ala Phe Cys Ile Pro Leu Tyr Val Pro Tyr Val Leu
                85                  90                  95      
Thr Gly Arg Trp Thr Phe Gly Arg Gly Leu Cys Lys Leu Trp Leu Val
            100                 105                 110         
Val Asp Tyr Leu Leu Cys Thr Ser Ser Ala Phe Asn Ile Val Leu Ile
        115                 120                 125             
Ser Tyr Asp Arg Phe Leu Ser Val Thr Arg Ala Val Ser Tyr Arg Ala
    130                 135                 140                 
Gln Gln Gly Asp Thr Arg Arg Ala Val Arg Lys Met Leu Leu Val Trp
145                 150                 155                 160 
Val Leu Ala Phe Leu Leu Tyr Gly Pro Ala Pro Ala Ala Pro Arg Gly
                165                 170                 175     
Ala Leu Arg Gly Arg Ala His Ser Arg Gly Ala Pro Ser Arg Arg Arg
            180                 185                 190         
Pro Arg Pro Arg Trp Arg Ser Ala
        195                 200 


<210> 6929
<211> 812
<212> PRT
<213> Homo sapiens

<400> 6929
Met His Gln Phe Phe Cys Arg Cys Lys Glu Gly Leu Gln Gly Val Thr
 1               5                  10                  15      
Leu Gly Ala Ala Pro Gly Asp Lys Leu Ile Pro Gln Trp Gly Cys Asn
            20                  25                  30          
Ile Ala Gln Gly Gln Trp Ser Leu Gly Arg Glu Trp Ser Pro Gly Gly
        35                  40                  45              
Val Gly Lys Gly Asp Gly Gly Arg Thr Trp Pro Ala Asp Ser Gly Leu
    50                  55                  60                  
Asp Ser His Thr His Thr Lys Glu Ala Gly Lys Cys Pro Glu Glu Ala
65                  70                  75                  80  
Gly Ala Ser Arg Arg Thr Asp Pro Gly Pro Cys Arg Ala Arg Pro Ala
                85                  90                  95      
Ala Pro Gly Pro Gly Ser Thr Ala Ala Leu Thr Pro Pro Arg Ser Pro
            100                 105                 110         
Pro Pro Pro Pro Leu Arg Pro Pro Pro Met Lys Arg Leu Pro Leu Leu
        115                 120                 125             
Val Val Phe Ser Thr Leu Leu Asn Cys Ser Tyr Thr Gln Asn Cys Thr
    130                 135                 140                 
Lys Thr Pro Cys Leu Pro Asn Ala Lys Cys Glu Ile Arg Asn Gly Ile
145                 150                 155                 160 
Glu Ala Cys Tyr Cys Asn Met Gly Phe Ser Gly Asn Gly Val Thr Ile
                165                 170                 175     
Cys Glu Asp Asp Asn Glu Cys Gly Asn Leu Thr Gln Ser Cys Gly Glu
            180                 185                 190         
Asn Ala Asn Cys Thr Asn Thr Glu Gly Ser Tyr Tyr Cys Met Cys Val
        195                 200                 205             
Pro Gly Phe Arg Ser Ser Ser Asn Gln Asp Arg Phe Ile Thr Asn Asp
    210                 215                 220                 
Gly Thr Val Cys Ile Glu Asn Val Asn Ala Asn Cys His Leu Asp Asn
225                 230                 235                 240 
Val Cys Ile Ala Ala Asn Ile Asn Lys Thr Leu Thr Lys Ile Arg Ser
                245                 250                 255     
Ile Lys Glu Pro Val Ala Leu Leu Gln Glu Val Tyr Arg Asn Ser Val
            260                 265                 270         
Thr Asp Leu Ser Pro Thr Asp Ile Ile Thr Tyr Ile Glu Ile Leu Ala
        275                 280                 285             
Glu Ser Ser Ser Leu Leu Gly Tyr Lys Asn Asn Thr Ile Ser Ala Lys
    290                 295                 300                 
Asp Thr Leu Ser Asn Ser Thr Leu Thr Glu Phe Val Lys Thr Val Asn
305                 310                 315                 320 
Asn Phe Val Gln Arg Asp Thr Phe Val Val Trp Asp Lys Leu Ser Val
                325                 330                 335     
Asn His Arg Arg Thr His Leu Thr Lys Leu Met His Thr Val Glu Gln
            340                 345                 350         
Ala Thr Leu Arg Ile Ser Gln Ser Phe Gln Lys Thr Thr Glu Phe Asp
        355                 360                 365             
Thr Asn Ser Thr Asp Ile Ala Leu Lys Val Phe Phe Phe Asp Ser Tyr
    370                 375                 380                 
Asn Met Lys His Ile His Pro His Met Asn Met Asp Gly Asp Tyr Ile
385                 390                 395                 400 
Asn Ile Phe Pro Lys Arg Lys Ala Ala Tyr Asp Ser Asn Gly Asn Val
                405                 410                 415     
Ala Val Ala Phe Val Tyr Tyr Lys Ser Ile Gly Pro Leu Leu Ser Ser
            420                 425                 430         
Ser Asp Asn Phe Leu Leu Lys Pro Gln Asn Tyr Asp Asn Ser Glu Glu
        435                 440                 445             
Glu Glu Arg Val Ile Ser Ser Val Ile Ser Val Ser Met Ser Ser Asn
    450                 455                 460                 
Pro Pro Thr Leu Tyr Glu Leu Glu Lys Ile Thr Phe Thr Leu Ser His
465                 470                 475                 480 
Arg Lys Val Thr Asp Arg Tyr Arg Ser Leu Cys Ala Phe Trp Asn Tyr
                485                 490                 495     
Ser Pro Asp Thr Met Asn Gly Ser Trp Ser Ser Glu Gly Cys Glu Leu
            500                 505                 510         
Thr Tyr Ser Asn Glu Thr His Thr Ser Cys Arg Cys Asn His Leu Thr
        515                 520                 525             
His Phe Ala Ile Leu Met Ser Ser Gly Pro Ser Ile Gly Ile Lys Asp
    530                 535                 540                 
Tyr Asn Ile Leu Thr Arg Ile Thr Gln Leu Gly Ile Ile Ile Ser Leu
545                 550                 555                 560 
Ile Cys Leu Ala Ile Cys Ile Phe Thr Phe Trp Phe Phe Ser Glu Ile
                565                 570                 575     
Gln Ser Thr Arg Thr Thr Ile His Lys Asn Leu Cys Cys Ser Leu Phe
            580                 585                 590         
Leu Ala Glu Leu Val Phe Leu Val Gly Ile Asn Thr Asn Thr Asn Lys
        595                 600                 605             
Leu Phe Cys Ser Ile Ile Ala Gly Leu Leu His Tyr Phe Phe Leu Ala
    610                 615                 620                 
Ala Phe Ala Trp Met Cys Ile Glu Gly Ile His Leu Tyr Leu Ile Val
625                 630                 635                 640 
Val Gly Val Ile Tyr Asn Lys Gly Phe Leu His Lys Asn Phe Tyr Ile
                645                 650                 655     
Phe Gly Tyr Leu Ser Pro Ala Val Val Val Gly Phe Ser Ala Ala Leu
            660                 665                 670         
Gly Tyr Arg Tyr Tyr Gly Thr Thr Lys Val Cys Trp Leu Ser Thr Glu
        675                 680                 685             
Asn Asn Phe Ile Trp Ser Phe Ile Gly Pro Ala Cys Leu Ile Ile Leu
    690                 695                 700                 
Val Asn Leu Leu Ala Phe Gly Val Ile Ile Tyr Lys Val Phe Arg His
705                 710                 715                 720 
Thr Ala Gly Leu Lys Pro Glu Val Ser Cys Phe Glu Asn Ile Arg Ser
                725                 730                 735     
Cys Ala Arg Gly Ala Leu Ala Leu Leu Phe Leu Leu Gly Thr Thr Trp
            740                 745                 750         
Ile Phe Gly Val Leu His Val Val His Ala Ser Val Val Thr Ala Tyr
        755                 760                 765             
Leu Phe Thr Val Ser Asn Ala Phe Gln Gly Met Phe Ile Phe Leu Phe
    770                 775                 780                 
Leu Cys Val Leu Ser Arg Lys Ile Gln Glu Glu Tyr Tyr Arg Leu Phe
785                 790                 795                 800 
Lys Asn Val Pro Cys Cys Phe Gly Cys Leu Ser Cys
                805                 810         


<210> 6930
<211> 1325
<212> PRT
<213> Homo sapiens

<400> 6930
Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala
 1               5                  10                  15      
Asn Ile Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys
            20                  25                  30          
Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu
        35                  40                  45              
Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp
    50                  55                  60                  
Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu
65                  70                  75                  80  
Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly
                85                  90                  95      
Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe
            100                 105                 110         
Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser
        115                 120                 125             
Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys
    130                 135                 140                 
Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln
145                 150                 155                 160 
Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg
                165                 170                 175     
Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly
            180                 185                 190         
Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val
        195                 200                 205             
Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala
    210                 215                 220                 
Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly
225                 230                 235                 240 
Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys
                245                 250                 255     
Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg
            260                 265                 270         
Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met
        275                 280                 285             
Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys
    290                 295                 300                 
Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn
305                 310                 315                 320 
Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe
                325                 330                 335     
Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe
            340                 345                 350         
Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe
        355                 360                 365             
Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg
    370                 375                 380                 
Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg
385                 390                 395                 400 
Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr
                405                 410                 415     
Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser
            420                 425                 430         
Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly
        435                 440                 445             
Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro
    450                 455                 460                 
Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln
465                 470                 475                 480 
Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly
                485                 490                 495     
Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala
            500                 505                 510         
Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile
        515                 520                 525             
Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn
    530                 535                 540                 
Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp
545                 550                 555                 560 
Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu
                565                 570                 575     
Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His
            580                 585                 590         
Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp
        595                 600                 605             
Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly
    610                 615                 620                 
Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln
625                 630                 635                 640 
Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu
                645                 650                 655     
Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly
            660                 665                 670         
Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu
        675                 680                 685             
Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr
    690                 695                 700                 
Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu
705                 710                 715                 720 
Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser
                725                 730                 735     
Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly
            740                 745                 750         
Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr
        755                 760                 765             
Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu
    770                 775                 780                 
Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys
785                 790                 795                 800 
Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn
                805                 810                 815     
Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu
            820                 825                 830         
Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Thr Leu Leu
        835                 840                 845             
Gln Val Val Gly Val Val Ser Val Ala Val Ala Val Ile Pro Trp Ile
    850                 855                 860                 
Ala Ile Pro Leu Val Pro Leu Gly Ile Ile Phe Ile Phe Leu Arg Arg
865                 870                 875                 880 
Tyr Phe Leu Glu Thr Ser Arg Asp Val Lys Arg Leu Glu Ser Thr Thr
                885                 890                 895     
Arg Ser Pro Val Phe Ser His Leu Ser Ser Ser Leu Gln Gly Leu Trp
            900                 905                 910         
Thr Ile Arg Ala Tyr Lys Ala Glu Glu Arg Cys Gln Glu Leu Phe Asp
        915                 920                 925             
Ala His Gln Asp Leu His Ser Glu Ala Trp Phe Leu Phe Leu Thr Thr
    930                 935                 940                 
Ser Arg Trp Phe Ala Val Arg Leu Asp Ala Ile Cys Ala Met Phe Val
945                 950                 955                 960 
Ile Ile Val Ala Phe Gly Ser Leu Ile Leu Ala Lys Thr Leu Asp Ala
                965                 970                 975     
Gly Gln Val Gly Leu Ala Leu Ser Tyr Ala Leu Thr Leu Met Gly Met
            980                 985                 990         
Phe Gln Trp Cys Val Arg Gln Ser Ala Glu Val Glu Asn Met Met Ile
        995                 1000                1005            
Ser Val Glu Arg Val Ile Glu Tyr Thr Asp Leu Glu Lys Glu Ala Pro
    1010                1015                1020                
Trp Glu Tyr Gln Lys Arg Pro Pro Pro Ala Trp Pro His Glu Gly Val
1025                1030                1035                1040
Ile Ile Phe Asp Asn Val Asn Phe Met Tyr Ser Pro Gly Gly Pro Leu
                1045                1050                1055    
Val Leu Lys His Leu Thr Ala Leu Ile Lys Ser Gln Glu Lys Val Gly
            1060                1065                1070        
Ile Val Gly Arg Thr Gly Ala Gly Lys Ser Ser Leu Ile Ser Ala Leu
        1075                1080                1085            
Phe Arg Leu Ser Glu Pro Glu Gly Lys Ile Trp Ile Asp Lys Ile Leu
    1090                1095                1100                
Thr Thr Glu Ile Gly Leu His Asp Leu Arg Lys Lys Met Ser Ile Ile
1105                1110                1115                1120
Pro Gln Glu Pro Val Leu Phe Thr Gly Thr Met Arg Lys Asn Leu Asp
                1125                1130                1135    
Pro Phe Lys Glu His Thr Asp Glu Glu Leu Trp Asn Ala Leu Gln Glu
            1140                1145                1150        
Val Gln Leu Lys Glu Thr Ile Glu Asp Leu Pro Gly Lys Met Asp Thr
        1155                1160                1165            
Glu Leu Ala Glu Ser Gly Ser Asn Phe Ser Val Gly Gln Arg Gln Leu
    1170                1175                1180                
Val Cys Leu Ala Arg Ala Ile Leu Arg Lys Asn Gln Ile Leu Ile Ile
1185                1190                1195                1200
Asp Glu Ala Thr Ala Asn Val Asp Pro Arg Thr Asp Glu Leu Ile Gln
                1205                1210                1215    
Lys Lys Ile Arg Glu Lys Phe Ala His Cys Thr Val Leu Thr Ile Ala
            1220                1225                1230        
His Arg Leu Asn Thr Ile Ile Asp Ser Asp Lys Ile Met Val Leu Asp
        1235                1240                1245            
Ser Gly Arg Leu Lys Glu Tyr Asp Glu Pro Tyr Val Leu Leu Gln Asn
    1250                1255                1260                
Lys Glu Ser Leu Phe Tyr Lys Met Val Gln Gln Leu Gly Lys Ala Glu
1265                1270                1275                1280
Ala Ala Ala Leu Thr Glu Thr Ala Lys Gln Val Tyr Phe Lys Arg Asn
                1285                1290                1295    
Tyr Pro His Ile Gly His Thr Asp His Met Val Thr Asn Thr Ser Asn
            1300                1305                1310        
Gly Gln Pro Ser Thr Leu Thr Ile Phe Glu Thr Ala Leu
        1315                1320                1325


<210> 6931
<211> 1059
<212> PRT
<213> Homo sapiens

<400> 6931
Met Lys Glu Ser Ser Leu Gln Asn Ser Ser Cys Ser Leu Gly Lys Glu
 1               5                  10                  15      
Thr Lys Lys Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile
            20                  25                  30          
Phe Leu Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe
        35                  40                  45              
Ser Arg Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile
    50                  55                  60                  
Ala Glu Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly
65                  70                  75                  80  
Lys Tyr Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile
                85                  90                  95      
Thr Asn Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu
            100                 105                 110         
Asn His Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln
        115                 120                 125             
Ser Asn Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn
    130                 135                 140                 
Leu Arg Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser
145                 150                 155                 160 
Gly Leu Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile
                165                 170                 175     
Tyr Asn Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn
            180                 185                 190         
Leu Tyr Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr
        195                 200                 205             
Asn Ile Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu
    210                 215                 220                 
Ser Leu Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser
225                 230                 235                 240 
Ser Leu Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser
                245                 250                 255     
Glu Glu Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser
            260                 265                 270         
Gly Asn Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys
        275                 280                 285             
Asp Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu
    290                 295                 300                 
Thr Gln Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile
305                 310                 315                 320 
Asn Ala Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu
                325                 330                 335     
Glu Phe Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr
            340                 345                 350         
Met Leu Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys
        355                 360                 365             
Gly Ser Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu
    370                 375                 380                 
Leu Ser Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu
385                 390                 395                 400 
Arg Glu Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr
                405                 410                 415     
Ile Asn Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe
            420                 425                 430         
Gln Asn Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile
        435                 440                 445             
Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser
    450                 455                 460                 
Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp
465                 470                 475                 480 
Pro His Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln
                485                 490                 495     
Cys Ala Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe
            500                 505                 510         
Phe Ile Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu
        515                 520                 525             
Asn Leu Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe
    530                 535                 540                 
Ser Ala Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu
545                 550                 555                 560 
Asp Phe Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val
                565                 570                 575     
Leu Asp Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr
            580                 585                 590         
His His Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn
        595                 600                 605             
Leu Ser His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu
    610                 615                 620                 
Ser Lys Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile
625                 630                 635                 640 
Leu Trp Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu
                645                 650                 655     
Lys Asn Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile
            660                 665                 670         
Pro Asn Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His
        675                 680                 685             
Ile Asn Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln
    690                 695                 700                 
Phe Pro Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe
705                 710                 715                 720 
Leu Thr Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu
                725                 730                 735     
Leu Ser His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu
            740                 745                 750         
Val Ser Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr
        755                 760                 765             
Ile Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met
    770                 775                 780                 
Leu Glu Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp
785                 790                 795                 800 
Phe Arg Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu
                805                 810                 815     
Val Asp Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile
            820                 825                 830         
Val Ser Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile
        835                 840                 845             
Leu Phe Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala
    850                 855                 860                 
Leu Ala His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val
865                 870                 875                 880 
Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr
                885                 890                 895     
Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr
            900                 905                 910         
Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp
        915                 920                 925             
Lys Asn Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu
    930                 935                 940                 
Ala Ile Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr
945                 950                 955                 960 
Val Phe Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr
                965                 970                 975     
Ala Phe Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val
            980                 985                 990         
Ile Ile Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu
        995                 1000                1005            
Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp
    1010                1015                1020                
Asn Pro Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val
1025                1030                1035                1040
Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile
                1045                1050                1055    
Lys Gln Tyr
            


<210> 6932
<211> 1041
<212> PRT
<213> Homo sapiens

<400> 6932
Met Glu Asn Met Phe Leu Gln Ser Ser Met Leu Thr Cys Ile Phe Leu
 1               5                  10                  15      
Leu Ile Ser Gly Ser Cys Glu Leu Cys Ala Glu Glu Asn Phe Ser Arg
            20                  25                  30          
Ser Tyr Pro Cys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile Ala Glu
        35                  40                  45              
Cys Ser Asn Arg Arg Leu Gln Glu Val Pro Gln Thr Val Gly Lys Tyr
    50                  55                  60                  
Val Thr Glu Leu Asp Leu Ser Asp Asn Phe Ile Thr His Ile Thr Asn
65                  70                  75                  80  
Glu Ser Phe Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu Asn His
                85                  90                  95      
Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln Ser Asn
            100                 105                 110         
Gly Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn Leu Arg
        115                 120                 125             
Glu Leu Leu Leu Glu Asp Asn Gln Leu Pro Gln Ile Pro Ser Gly Leu
    130                 135                 140                 
Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn
145                 150                 155                 160 
Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr
                165                 170                 175     
Leu Ala Trp Asn Cys Tyr Phe Asn Lys Val Cys Glu Lys Thr Asn Ile
            180                 185                 190         
Glu Asp Gly Val Phe Glu Thr Leu Thr Asn Leu Glu Leu Leu Ser Leu
        195                 200                 205             
Ser Phe Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu
    210                 215                 220                 
Arg Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Ile Ser Glu Glu
225                 230                 235                 240 
Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly Asn
                245                 250                 255     
Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys Asp Gly
            260                 265                 270         
Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln
        275                 280                 285             
Leu Arg Tyr Leu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala
    290                 295                 300                 
Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu Glu Phe
305                 310                 315                 320 
Asn Tyr Leu Val Gly Glu Ile Ala Ser Gly Ala Phe Leu Thr Met Leu
                325                 330                 335     
Pro Arg Leu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser
            340                 345                 350         
Tyr Pro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser
        355                 360                 365             
Leu Arg Ala Leu His Leu Arg Gly Tyr Val Phe Gln Glu Leu Arg Glu
    370                 375                 380                 
Asp Asp Phe Gln Pro Leu Met Gln Leu Pro Asn Leu Ser Thr Ile Asn
385                 390                 395                 400 
Leu Gly Ile Asn Phe Ile Lys Gln Ile Asp Phe Lys Leu Phe Gln Asn
                405                 410                 415     
Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro
            420                 425                 430         
Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln
        435                 440                 445             
Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His
    450                 455                 460                 
Ser Asn Phe Tyr His Phe Thr Arg Pro Leu Ile Lys Pro Gln Cys Ala
465                 470                 475                 480 
Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe Ile
                485                 490                 495     
Gly Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu Asn Leu
            500                 505                 510         
Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe Ser Ala
        515                 520                 525             
Ile Pro His Val Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu Asp Phe
    530                 535                 540                 
Asp Asn Ala Ser Ala Leu Thr Glu Leu Ser Asp Leu Glu Val Leu Asp
545                 550                 555                 560 
Leu Ser Tyr Asn Ser His Tyr Phe Arg Ile Ala Gly Val Thr His His
                565                 570                 575     
Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn Leu Ser
            580                 585                 590         
His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu Ser Lys
        595                 600                 605             
Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile Leu Trp
    610                 615                 620                 
Asn Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly Leu Lys Asn
625                 630                 635                 640 
Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu Lys His Ile Pro Asn
                645                 650                 655     
Glu Ala Phe Leu Asn Leu Pro Ala Ser Leu Thr Glu Leu His Ile Asn
            660                 665                 670         
Asp Asn Met Leu Lys Phe Phe Asn Trp Thr Leu Leu Gln Gln Phe Pro
        675                 680                 685             
Arg Leu Glu Leu Leu Asp Leu Arg Gly Asn Lys Leu Leu Phe Leu Thr
    690                 695                 700                 
Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser
705                 710                 715                 720 
His Asn Arg Ile Ser His Leu Pro Ser Gly Phe Leu Ser Glu Val Ser
                725                 730                 735     
Ser Leu Lys His Leu Asp Leu Ser Ser Asn Leu Leu Lys Thr Ile Asn
            740                 745                 750         
Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser Met Leu Glu
        755                 760                 765             
Leu His Gly Asn Pro Phe Glu Cys Thr Cys Asp Ile Gly Asp Phe Arg
    770                 775                 780                 
Arg Trp Met Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu Val Asp
785                 790                 795                 800 
Val Ile Cys Ala Ser Pro Gly Asp Gln Arg Gly Lys Ser Ile Val Ser
                805                 810                 815     
Leu Glu Leu Thr Thr Cys Val Ser Asp Val Thr Ala Val Ile Leu Phe
            820                 825                 830         
Phe Phe Thr Phe Phe Ile Thr Thr Met Val Met Leu Ala Ala Leu Ala
        835                 840                 845             
His His Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu
    850                 855                 860                 
Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser Gln Thr Phe Tyr
865                 870                 875                 880 
Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp
                885                 890                 895     
Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn
            900                 905                 910         
Val Leu Leu Cys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile
        915                 920                 925             
Ile Asp Asn Leu Met Gln Ser Ile Asn Gln Ser Lys Lys Thr Val Phe
    930                 935                 940                 
Val Leu Thr Lys Lys Tyr Ala Lys Ser Trp Asn Phe Lys Thr Ala Phe
945                 950                 955                 960 
Tyr Leu Ala Leu Gln Arg Leu Met Asp Glu Asn Met Asp Val Ile Ile
                965                 970                 975     
Phe Ile Leu Leu Glu Pro Val Leu Gln His Ser Gln Tyr Leu Arg Leu
            980                 985                 990         
Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro
        995                 1000                1005            
Lys Ala Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr
    1010                1015                1020                
Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Gln
1025                1030                1035                1040
Tyr
    


<210> 6933
<211> 804
<212> PRT
<213> Homo sapiens

<400> 6933
Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp
 1               5                  10                  15      
Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser
            20                  25                  30          
Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val
        35                  40                  45              
Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn
    50                  55                  60                  
Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn
65                  70                  75                  80  
Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val
                85                  90                  95      
Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val
            100                 105                 110         
Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Phe Val
        115                 120                 125             
Ala Gln Pro Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu
    130                 135                 140                 
Phe Pro Gly Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys
145                 150                 155                 160 
Phe Ile Ile Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile
                165                 170                 175     
Ala Pro Lys Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys
            180                 185                 190         
Phe Ile Cys His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu
        195                 200                 205             
Leu Ala Ser Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro
    210                 215                 220                 
Pro Pro Thr Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe
225                 230                 235                 240 
Ile Trp Gly Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr
                245                 250                 255     
Ile His Asp Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr
            260                 265                 270         
Leu Ala Thr Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala
        275                 280                 285             
Leu Asn Pro Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala
    290                 295                 300                 
Glu Ala Leu Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile
305                 310                 315                 320 
Ser Leu Phe Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu
                325                 330                 335     
Gly Arg Met Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu
            340                 345                 350         
Val Leu Leu Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr
        355                 360                 365             
Glu Glu Thr Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln
    370                 375                 380                 
Asn Asn Ala Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp
385                 390                 395                 400 
Ser Ile Phe Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln
                405                 410                 415     
His Glu Phe Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn
            420                 425                 430         
Val Ile Ser Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn
        435                 440                 445             
Asn Ser Tyr Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe
    450                 455                 460                 
Ala Arg Thr Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu
465                 470                 475                 480 
Pro Thr Pro Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu
                485                 490                 495     
Ile Lys Trp Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys
            500                 505                 510         
Pro Glu Ser Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg
        515                 520                 525             
Arg His His Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr
    530                 535                 540                 
Val Ala Ala Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu
545                 550                 555                 560 
Glu Asn Phe Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu
                565                 570                 575     
Val Leu Gly Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala
            580                 585                 590         
Asn Ala Ser Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser
        595                 600                 605             
Asp Ser Glu Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser Leu Phe
    610                 615                 620                 
Asp Leu Thr Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala Ser Glu
625                 630                 635                 640 
Arg His Asn Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu Pro Pro
                645                 650                 655     
Arg Glu Lys Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys Asn Phe
            660                 665                 670         
Gly Leu Phe His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln Asn Ala
        675                 680                 685             
Asn Gln Ile Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln Ala Ala
    690                 695                 700                 
Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser
705                 710                 715                 720 
Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val
                725                 730                 735     
Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys
            740                 745                 750         
Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val
        755                 760                 765             
Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile
    770                 775                 780                 
Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val
785                 790                 795                 800 
Thr Thr Arg Leu
                


<210> 6934
<211> 893
<212> PRT
<213> Homo sapiens

<400> 6934
Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp
 1               5                  10                  15      
Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser
            20                  25                  30          
Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val
        35                  40                  45              
Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn
    50                  55                  60                  
Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn
65                  70                  75                  80  
Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val
                85                  90                  95      
Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val
            100                 105                 110         
Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro
        115                 120                 125             
Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr
    130                 135                 140                 
Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu
145                 150                 155                 160 
Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys
                165                 170                 175     
Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His
            180                 185                 190         
Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu
        195                 200                 205             
Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser
    210                 215                 220                 
Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu
225                 230                 235                 240 
Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu
                245                 250                 255     
Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg
            260                 265                 270         
Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg
        275                 280                 285             
Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro
    290                 295                 300                 
Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly
305                 310                 315                 320 
Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile
                325                 330                 335     
Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys
            340                 345                 350         
Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys
        355                 360                 365             
His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser
    370                 375                 380                 
Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr
385                 390                 395                 400 
Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly
                405                 410                 415     
Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp
            420                 425                 430         
Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr
        435                 440                 445             
Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro
    450                 455                 460                 
Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu
465                 470                 475                 480 
Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe
                485                 490                 495     
Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met
            500                 505                 510         
Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu
        515                 520                 525             
Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr
    530                 535                 540                 
Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala
545                 550                 555                 560 
Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe
                565                 570                 575     
Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe
            580                 585                 590         
Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser
        595                 600                 605             
Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr
    610                 615                 620                 
Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr
625                 630                 635                 640 
Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro
                645                 650                 655     
Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp
            660                 665                 670         
Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser
        675                 680                 685             
Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His
    690                 695                 700                 
Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala
705                 710                 715                 720 
Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe
                725                 730                 735     
Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly
            740                 745                 750         
Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser
        755                 760                 765             
Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu
    770                 775                 780                 
Glu Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu Glu Arg Asn Ile
785                 790                 795                 800 
Gln Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp Leu Ser Ile Pro
                805                 810                 815     
Gly Leu Ser Glu Gln Cys Val Leu Val Asp His Arg Glu Arg Asn Thr
            820                 825                 830         
Asp Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys Pro Phe Lys Ser
        835                 840                 845             
Glu Lys Val Val Val Glu Asp Thr Val Pro Ile Ile Pro Lys Glu Lys
    850                 855                 860                 
His Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp Leu Asn Leu Pro
865                 870                 875                 880 
Asp Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg Leu
                885                 890             


<210> 6935
<211> 836
<212> PRT
<213> Homo sapiens

<400> 6935
Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp
 1               5                  10                  15      
Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser
            20                  25                  30          
Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val
        35                  40                  45              
Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn
    50                  55                  60                  
Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn
65                  70                  75                  80  
Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val
                85                  90                  95      
Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val
            100                 105                 110         
Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro
        115                 120                 125             
Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr
    130                 135                 140                 
Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu
145                 150                 155                 160 
Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys
                165                 170                 175     
Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His
            180                 185                 190         
Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu
        195                 200                 205             
Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser
    210                 215                 220                 
Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu
225                 230                 235                 240 
Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu
                245                 250                 255     
Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg
            260                 265                 270         
Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg
        275                 280                 285             
Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro
    290                 295                 300                 
Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly
305                 310                 315                 320 
Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile
                325                 330                 335     
Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys
            340                 345                 350         
Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys
        355                 360                 365             
His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser
    370                 375                 380                 
Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr
385                 390                 395                 400 
Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly
                405                 410                 415     
Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp
            420                 425                 430         
Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr
        435                 440                 445             
Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro
    450                 455                 460                 
Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu
465                 470                 475                 480 
Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe
                485                 490                 495     
Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met
            500                 505                 510         
Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu
        515                 520                 525             
Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr
    530                 535                 540                 
Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala
545                 550                 555                 560 
Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe
                565                 570                 575     
Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe
            580                 585                 590         
Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser
        595                 600                 605             
Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr
    610                 615                 620                 
Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr
625                 630                 635                 640 
Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro
                645                 650                 655     
Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp
            660                 665                 670         
Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser
        675                 680                 685             
Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His
    690                 695                 700                 
Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala
705                 710                 715                 720 
Met Ile Arg Asp Ala Lys Thr Glu Glu Val Ala Arg Gln Gln Ala Ala
                725                 730                 735     
Gly Pro Leu Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser
            740                 745                 750         
Arg Gly Asp Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val
        755                 760                 765             
Asp His Arg Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys
    770                 775                 780                 
Arg Val Cys Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val
785                 790                 795                 800 
Pro Ile Ile Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile
                805                 810                 815     
Asp Tyr Asp Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val
            820                 825                 830         
Thr Thr Arg Leu
        835     


<210> 6936
<211> 977
<212> PRT
<213> Homo sapiens

<400> 6936
Met Ala Gln Phe Tyr Tyr Lys Arg Asn Val Asn Ala Pro Tyr Arg Asp
 1               5                  10                  15      
Arg Ile Pro Leu Arg Ile Val Arg Ala Glu Ser Glu Leu Ser Pro Ser
            20                  25                  30          
Glu Lys Ala Tyr Leu Asn Ala Val Glu Lys Gly Asp Tyr Ala Ser Val
        35                  40                  45              
Lys Lys Ser Leu Glu Glu Ala Glu Ile Tyr Phe Lys Ile Asn Ile Asn
    50                  55                  60                  
Cys Ile Asp Pro Leu Gly Arg Thr Ala Leu Leu Ile Ala Ile Glu Asn
65                  70                  75                  80  
Glu Asn Leu Glu Leu Ile Glu Leu Leu Leu Ser Phe Asn Val Tyr Val
                85                  90                  95      
Gly Asp Ala Leu Leu His Ala Ile Arg Lys Glu Val Val Gly Ala Val
            100                 105                 110         
Glu Leu Leu Leu Asn His Lys Lys Pro Ser Gly Glu Lys Gln Val Pro
        115                 120                 125             
Pro Ile Leu Leu Asp Lys Gln Phe Ser Glu Phe Thr Pro Asp Ile Thr
    130                 135                 140                 
Pro Ile Ile Leu Ala Ala His Thr Asn Asn Tyr Glu Ile Ile Lys Leu
145                 150                 155                 160 
Leu Val Gln Lys Gly Val Ser Val Pro Arg Pro His Glu Val Arg Cys
                165                 170                 175     
Asn Cys Val Glu Cys Val Ser Ser Ser Asp Val Asp Ser Leu Arg His
            180                 185                 190         
Ser Arg Ser Arg Leu Asn Ile Tyr Lys Ala Leu Ala Ser Pro Ser Leu
        195                 200                 205             
Ile Ala Leu Ser Ser Glu Asp Pro Phe Leu Thr Ala Phe Gln Leu Ser
    210                 215                 220                 
Trp Glu Leu Gln Glu Leu Ser Lys Val Glu Asn Glu Phe Lys Ser Glu
225                 230                 235                 240 
Tyr Glu Glu Leu Ser Arg Gln Cys Lys Gln Phe Ala Lys Asp Leu Leu
                245                 250                 255     
Asp Gln Thr Arg Ser Ser Arg Glu Leu Glu Ile Ile Leu Asn Tyr Arg
            260                 265                 270         
Asp Asp Asn Ser Leu Ile Glu Glu Gln Ser Gly Asn Asp Leu Ala Arg
        275                 280                 285             
Leu Lys Leu Ala Ile Lys Tyr Arg Gln Lys Glu Phe Val Ala Gln Pro
    290                 295                 300                 
Asn Cys Gln Gln Leu Leu Ala Ser Arg Trp Tyr Asp Glu Phe Pro Gly
305                 310                 315                 320 
Trp Arg Arg Arg His Trp Ala Val Lys Met Val Thr Cys Phe Ile Ile
                325                 330                 335     
Gly Leu Leu Phe Pro Val Phe Ser Val Cys Tyr Leu Ile Ala Pro Lys
            340                 345                 350         
Ser Pro Leu Gly Leu Phe Ile Arg Lys Pro Phe Ile Lys Phe Ile Cys
        355                 360                 365             
His Thr Ala Ser Tyr Leu Thr Phe Leu Phe Leu Leu Leu Leu Ala Ser
    370                 375                 380                 
Gln His Ile Asp Arg Ser Asp Leu Asn Arg Gln Gly Pro Pro Pro Thr
385                 390                 395                 400 
Ile Val Glu Trp Met Ile Leu Pro Trp Val Leu Gly Phe Ile Trp Gly
                405                 410                 415     
Glu Ile Lys Gln Met Trp Asp Gly Gly Leu Gln Asp Tyr Ile His Asp
            420                 425                 430         
Trp Trp Asn Leu Met Asp Phe Val Met Asn Ser Leu Tyr Leu Ala Thr
        435                 440                 445             
Ile Ser Leu Lys Ile Val Ala Phe Val Lys Tyr Ser Ala Leu Asn Pro
    450                 455                 460                 
Arg Glu Ser Trp Asp Met Trp His Pro Thr Leu Val Ala Glu Ala Leu
465                 470                 475                 480 
Phe Ala Ile Ala Asn Ile Phe Ser Ser Leu Arg Leu Ile Ser Leu Phe
                485                 490                 495     
Thr Ala Asn Ser His Leu Gly Pro Leu Gln Ile Ser Leu Gly Arg Met
            500                 505                 510         
Leu Leu Asp Ile Leu Lys Phe Leu Phe Ile Tyr Cys Leu Val Leu Leu
        515                 520                 525             
Ala Phe Ala Asn Gly Leu Asn Gln Leu Tyr Phe Tyr Tyr Glu Glu Thr
    530                 535                 540                 
Lys Gly Leu Thr Cys Lys Gly Ile Arg Cys Glu Lys Gln Asn Asn Ala
545                 550                 555                 560 
Phe Ser Thr Leu Phe Glu Thr Leu Gln Ser Leu Phe Trp Ser Ile Phe
                565                 570                 575     
Gly Leu Ile Asn Leu Tyr Val Thr Asn Val Lys Ala Gln His Glu Phe
            580                 585                 590         
Thr Glu Phe Val Gly Ala Thr Met Phe Gly Thr Tyr Asn Val Ile Ser
        595                 600                 605             
Leu Val Val Leu Leu Asn Met Leu Ile Ala Met Met Asn Asn Ser Tyr
    610                 615                 620                 
Gln Leu Ile Ala Asp His Ala Asp Ile Glu Trp Lys Phe Ala Arg Thr
625                 630                 635                 640 
Lys Leu Trp Met Ser Tyr Phe Glu Glu Gly Gly Thr Leu Pro Thr Pro
                645                 650                 655     
Phe Asn Val Ile Pro Ser Pro Lys Ser Leu Trp Tyr Leu Ile Lys Trp
            660                 665                 670         
Ile Trp Thr His Leu Cys Lys Lys Lys Met Arg Arg Lys Pro Glu Ser
        675                 680                 685             
Phe Gly Thr Ile Gly Arg Arg Ala Ala Asp Asn Leu Arg Arg His His
    690                 695                 700                 
Gln Tyr Gln Glu Val Met Arg Asn Leu Val Lys Arg Tyr Val Ala Ala
705                 710                 715                 720 
Met Ile Arg Asp Ala Lys Thr Glu Glu Gly Leu Thr Glu Glu Asn Phe
                725                 730                 735     
Lys Glu Leu Lys Gln Asp Ile Ser Ser Phe Arg Phe Glu Val Leu Gly
            740                 745                 750         
Leu Leu Arg Gly Ser Lys Leu Ser Thr Ile Gln Ser Ala Asn Ala Ser
        755                 760                 765             
Lys Glu Ser Ser Asn Ser Ala Asp Ser Asp Glu Lys Ser Asp Ser Glu
    770                 775                 780                 
Gly Asn Ser Lys Asp Lys Lys Lys Asn Phe Ser Leu Phe Asp Leu Thr
785                 790                 795                 800 
Thr Leu Ile His Pro Arg Ser Ala Ala Ile Ala Ser Glu Arg His Asn
                805                 810                 815     
Ile Ser Asn Gly Ser Ala Leu Val Val Gln Glu Pro Pro Arg Glu Lys
            820                 825                 830         
Gln Arg Lys Val Asn Phe Val Thr Asp Ile Lys Asn Phe Gly Leu Phe
        835                 840                 845             
His Arg Arg Ser Lys Gln Asn Ala Ala Glu Gln Asn Ala Asn Gln Ile
    850                 855                 860                 
Phe Ser Val Ser Glu Glu Val Ala Arg Gln Gln Ala Ala Gly Pro Leu
865                 870                 875                 880 
Glu Arg Asn Ile Gln Leu Glu Ser Arg Gly Leu Ala Ser Arg Gly Asp
                885                 890                 895     
Leu Ser Ile Pro Gly Leu Ser Glu Gln Cys Val Leu Val Asp His Arg
            900                 905                 910         
Glu Arg Asn Thr Asp Thr Leu Gly Leu Gln Val Gly Lys Arg Val Cys
        915                 920                 925             
Pro Phe Lys Ser Glu Lys Val Val Val Glu Asp Thr Val Pro Ile Ile
    930                 935                 940                 
Pro Lys Glu Lys His Ala Lys Glu Glu Asp Ser Ser Ile Asp Tyr Asp
945                 950                 955                 960 
Leu Asn Leu Pro Asp Thr Val Thr His Glu Asp Tyr Val Thr Thr Arg
                965                 970                 975     
Leu
    


<210> 6937
<211> 1240
<212> PRT
<213> Homo sapiens

<400> 6937
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile
 1               5                  10                  15      
Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg
            20                  25                  30          
Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Thr
        35                  40                  45              
Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Thr Asp Asp Lys
    50                  55                  60                  
Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu
65                  70                  75                  80  
Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Thr Gln
                85                  90                  95      
Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly
            100                 105                 110         
Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val
        115                 120                 125             
Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln
    130                 135                 140                 
Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys
145                 150                 155                 160 
Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Thr Pro
                165                 170                 175     
Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys Asp Asp Phe Ile
            180                 185                 190         
Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His Arg Val Asp Gly
        195                 200                 205             
Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg
    210                 215                 220                 
Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser Gly
225                 230                 235                 240 
Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr Ser Pro Tyr Arg
                245                 250                 255     
Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu
            260                 265                 270         
Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys Ile Val Ile Ser
        275                 280                 285             
Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr Trp Asp Thr Ala
    290                 295                 300                 
Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu
305                 310                 315                 320 
Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Thr Gly
                325                 330                 335     
Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser Lys Asp Ser Leu
            340                 345                 350         
Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp
        355                 360                 365             
Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val
    370                 375                 380                 
Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln
385                 390                 395                 400 
Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp
                405                 410                 415     
Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Thr Thr Gly Pro
            420                 425                 430         
Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu Arg Thr Thr Thr
        435                 440                 445             
Leu Ser Pro Gly Arg Ser Thr Thr Pro Ser Val Ser Gly Arg Arg Asn
    450                 455                 460                 
Arg Ser Thr Ser Thr Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met
465                 470                 475                 480 
Thr Thr His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu
                485                 490                 495     
Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Thr Arg
            500                 505                 510         
Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Thr Ile Gly Val
        515                 520                 525             
Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly
    530                 535                 540                 
Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Thr Gln
545                 550                 555                 560 
Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg Glu Leu Ala
                565                 570                 575     
Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr Tyr Ser Val
            580                 585                 590         
Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn
        595                 600                 605             
Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu
    610                 615                 620                 
Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu
625                 630                 635                 640 
Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp
                645                 650                 655     
Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu Leu His Thr
            660                 665                 670         
Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Thr Asp
        675                 680                 685             
Ile Val Arg Glu Asn Thr Asp Asn Ile Lys Leu Glu Val Ala Arg Leu
    690                 695                 700                 
Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly
705                 710                 715                 720 
His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys Gln Asn Gly
                725                 730                 735     
Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly
            740                 745                 750         
Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly Thr Glu Ala
        755                 760                 765             
Leu Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val Ile Thr Ala
    770                 775                 780                 
Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val
785                 790                 795                 800 
Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro
                805                 810                 815     
Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr Gly Tyr Trp
            820                 825                 830         
Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr His Thr Thr
        835                 840                 845             
Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met Ala His Val
    850                 855                 860                 
Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile
865                 870                 875                 880 
Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile
                885                 890                 895     
Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile
            900                 905                 910         
His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu
        915                 920                 925             
Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala Val Phe Ala
    930                 935                 940                 
Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp Met Phe Leu
945                 950                 955                 960 
Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu
                965                 970                 975     
His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala
            980                 985                 990         
Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg Ser Tyr Gly Thr
        995                 1000                1005            
Asp Lys Val Cys Trp Leu Arg Leu Asp Thr Tyr Phe Ile Trp Ser Phe
    1010                1015                1020                
Ile Gly Pro Ala Thr Leu Ile Ile Met Leu Asn Val Ile Phe Leu Gly
1025                1030                1035                1040
Ile Ala Leu Tyr Lys Met Phe His His Thr Ala Ile Leu Lys Pro Glu
                1045                1050                1055    
Ser Gly Cys Leu Asp Asn Ile Asn Tyr Glu Asp Asn Arg Pro Phe Ile
            1060                1065                1070        
Lys Ser Trp Val Ile Gly Ala Ile Ala Leu Leu Cys Leu Leu Gly Leu
        1075                1080                1085            
Thr Trp Ala Phe Gly Leu Met Tyr Ile Asn Glu Ser Thr Val Ile Met
    1090                1095                1100                
Ala Tyr Leu Phe Thr Ile Phe Asn Ser Leu Gln Gly Met Phe Ile Phe
1105                1110                1115                1120
Ile Phe His Cys Val Leu Gln Lys Lys Val Arg Lys Glu Tyr Gly Lys
                1125                1130                1135    
Cys Leu Arg Thr His Cys Cys Ser Gly Lys Ser Thr Glu Ser Ser Ile
            1140                1145                1150        
Gly Ser Gly Lys Thr Ser Gly Ser Arg Thr Pro Gly Arg Tyr Ser Thr
        1155                1160                1165            
Gly Ser Gln Ser Arg Ile Arg Arg Met Trp Asn Asp Thr Val Arg Lys
    1170                1175                1180                
Gln Ser Glu Ser Ser Phe Ile Thr Gly Asp Ile Asn Ser Ser Ala Ser
1185                1190                1195                1200
Leu Asn Arg Glu Pro Tyr Arg Glu Thr Ser Met Gly Val Lys Leu Asn
                1205                1210                1215    
Ile Ala Tyr Gln Ile Gly Ala Ser Glu Gln Cys Gln Gly Tyr Lys Cys
            1220                1225                1230        
His Gly Tyr Ser Thr Thr Glu Trp
        1235                1240


<210> 6938
<211> 872
<212> PRT
<213> Homo sapiens

<400> 6938
Ala Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr Tyr Ser
 1               5                  10                  15      
Val Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg
            20                  25                  30          
Asn Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys
        35                  40                  45              
Ala Met Val Glu Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn
    50                  55                  60                  
Ala Trp Arg Asp Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met
65                  70                  75                  80  
Leu Leu His Thr Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu
                85                  90                  95      
Leu Lys Thr Asp Ile Val Arg Glu Asn Thr Asp Asn Ile Lys Leu Glu
            100                 105                 110         
Val Ala Arg Leu Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro
        115                 120                 125             
Glu Asn Met Gly His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu
    130                 135                 140                 
Lys Gln Asn Gly Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr
145                 150                 155                 160 
Asn Asn Leu Gly Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu
                165                 170                 175     
Gly Thr Glu Ala Leu Ser Thr Asn His Ser Val Ile Val Asn Ser Pro
            180                 185                 190         
Val Ile Thr Ala Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu
        195                 200                 205             
Ala Asp Pro Val Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu
    210                 215                 220                 
Asn Phe Asn Pro Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met
225                 230                 235                 240 
Thr Gly Tyr Trp Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys
                245                 250                 255     
Thr His Thr Thr Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu
            260                 265                 270         
Met Ala His Val Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu
        275                 280                 285             
Leu Asp Val Ile Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu
    290                 295                 300                 
Leu Ile Cys Ile Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp
305                 310                 315                 320 
Arg Asn Thr Ile His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu
                325                 330                 335     
Leu Leu Phe Leu Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys
            340                 345                 350         
Ala Val Phe Ala Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr
        355                 360                 365             
Trp Met Phe Leu Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val
    370                 375                 380                 
Phe Glu Ser Glu His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr
385                 390                 395                 400 
Gly Met Pro Ala Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg
                405                 410                 415     
Ser Tyr Gly Thr Asp Lys Val Cys Trp Leu Arg Leu Asp Thr Tyr Phe
            420                 425                 430         
Ile Trp Ser Phe Ile Gly Pro Ala Thr Leu Ile Ile Met Leu Asn Val
        435                 440                 445             
Ile Phe Leu Gly Ile Ala Leu Tyr Lys Met Phe His His Thr Ala Ile
    450                 455                 460                 
Leu Lys Pro Glu Ser Gly Cys Leu Asp Asn Ile Lys Ser Trp Val Ile
465                 470                 475                 480 
Gly Ala Ile Ala Leu Leu Cys Leu Leu Gly Leu Thr Trp Ala Phe Gly
                485                 490                 495     
Leu Met Tyr Ile Asn Glu Ser Thr Val Ile Met Ala Tyr Leu Phe Thr
            500                 505                 510         
Ile Phe Asn Ser Leu Gln Gly Met Phe Ile Phe Ile Phe His Cys Val
        515                 520                 525             
Leu Gln Lys Lys Val Arg Lys Glu Tyr Gly Lys Cys Leu Arg Thr His
    530                 535                 540                 
Cys Cys Ser Gly Lys Ser Thr Glu Ser Ser Ile Gly Ser Gly Lys Thr
545                 550                 555                 560 
Ser Gly Ser Arg Thr Pro Gly Arg Tyr Ser Thr Gly Ser Gln Ser Arg
                565                 570                 575     
Ile Arg Arg Met Trp Asn Asp Thr Val Arg Lys Gln Ser Glu Ser Ser
            580                 585                 590         
Phe Ile Thr Gly Asp Ile Asn Ser Ser Ala Ser Leu Asn Arg Glu Gly
        595                 600                 605             
Leu Leu Asn Asn Ala Arg Asp Thr Ser Val Met Asp Thr Leu Pro Leu
    610                 615                 620                 
Asn Gly Asn His Gly Asn Ser Tyr Ser Ile Ala Ser Gly Glu Tyr Leu
625                 630                 635                 640 
Ser Asn Cys Val Gln Ile Ile Asp Arg Gly Tyr Asn His Asn Glu Thr
                645                 650                 655     
Ala Leu Glu Lys Lys Ile Leu Lys Glu Leu Thr Ser Asn Tyr Ile Pro
            660                 665                 670         
Ser Tyr Leu Asn Asn His Glu Arg Ser Ser Glu Gln Asn Arg Asn Leu
        675                 680                 685             
Met Asn Lys Leu Val Asn Asn Leu Gly Ser Gly Arg Glu Asp Asp Ala
    690                 695                 700                 
Ile Val Leu Asp Asp Ala Thr Ser Phe Asn His Glu Glu Ser Leu Gly
705                 710                 715                 720 
Leu Glu Leu Ile His Glu Glu Ser Asp Ala Pro Leu Leu Pro Pro Arg
                725                 730                 735     
Val Tyr Ser Thr Glu Asn His Gln Pro His His Tyr Thr Arg Arg Arg
            740                 745                 750         
Ile Pro Gln Asp His Ser Glu Ser Phe Phe Pro Leu Leu Thr Asn Glu
        755                 760                 765             
His Thr Glu Asp Leu Gln Ser Pro His Arg Asp Ser Leu Tyr Thr Ser
    770                 775                 780                 
Met Pro Thr Leu Ala Gly Val Ala Ala Thr Glu Ser Val Thr Thr Ser
785                 790                 795                 800 
Thr Gln Thr Glu Pro Pro Pro Ala Lys Cys Gly Asp Ala Glu Asp Val
                805                 810                 815     
Tyr Tyr Lys Ser Met Pro Asn Leu Gly Ser Arg Asn His Val His Gln
            820                 825                 830         
Leu His Thr Tyr Tyr Gln Leu Gly Arg Gly Ser Ser Asp Gly Phe Ile
        835                 840                 845             
Val Pro Pro Asn Lys Asp Gly Thr Pro Pro Glu Gly Ser Ser Lys Gly
    850                 855                 860                 
Pro Ala His Leu Val Thr Ser Leu
865                 870         


<210> 6939
<211> 941
<212> PRT
<213> Homo sapiens

<400> 6939
Met Thr Val His Ser Ser Val His Ser Asn Asn Leu Asn Ser Met Pro
 1               5                  10                  15      
Ala Ala Glu Lys Gly Lys Asp Thr Leu Lys Ser Ala Tyr Asp Asp Thr
            20                  25                  30          
Glu Asn Asp Leu Lys Gly Ala Ala Ile His Ile Ser Lys Gly Met Leu
        35                  40                  45              
His Glu Glu Lys Pro Gly Glu Gln Ile Leu Glu Gly Gly Ser Glu Ser
    50                  55                  60                  
Glu Ser Ala Gln Lys Ala Ala Gly Asn Gln Met Asn Asp Arg Lys Ile
65                  70                  75                  80  
Gln Gln Glu Ser Leu Gly Ser Ala Pro Leu Met Gly Asp Asp His Pro
                85                  90                  95      
Asn Ala Ser Arg Asp Ser Val Glu Gly Asp Ala Leu Val Asn Gly Ala
            100                 105                 110         
Lys Leu His Thr Leu Ser Val Glu His Gln Arg Glu Glu Leu Lys Glu
        115                 120                 125             
Glu Leu Val Leu Lys Thr Gln Asn Gln Pro Arg Phe Ser Ser Pro Asp
    130                 135                 140                 
Glu Ile Asp Leu Pro Arg Glu Leu Glu Asp Glu Val Pro Ile Leu Gly
145                 150                 155                 160 
Arg Asn Leu Pro Trp Gln Gln Glu Arg Asp Val Ala Ala Thr Ala Ser
                165                 170                 175     
Lys Gln Met Ser Glu Lys Ile Arg Leu Ser Glu Gly Glu Ala Lys Glu
            180                 185                 190         
Asp Ser Leu Asp Glu Glu Phe Phe His His Lys Ala Met Gln Gly Thr
        195                 200                 205             
Glu Val Gly Gln Thr Asp Gln Thr Asp Ser Thr Gly Gly Pro Ala Phe
    210                 215                 220                 
Leu Ser Lys Val Glu Glu Asp Asp Tyr Pro Ser Glu Glu Leu Leu Glu
225                 230                 235                 240 
Asp Glu Asn Ala Ile Asn Ala Lys Arg Ser Lys Glu Lys Asn Pro Gly
                245                 250                 255     
Asn Gln Gly Arg Gln Phe Asp Val Asn Leu Gln Val Pro Asp Arg Ala
            260                 265                 270         
Val Leu Gly Thr Ile His Pro Asp Pro Glu Ile Glu Glu Ser Lys Gln
        275                 280                 285             
Glu Thr Ser Met Ile Leu Asp Ser Glu Lys Thr Ser Glu Thr Ala Ala
    290                 295                 300                 
Lys Gly Val Asn Thr Gly Gly Arg Glu Pro Asn Thr Met Val Glu Lys
305                 310                 315                 320 
Glu Arg Pro Leu Ala Asp Lys Lys Ala Gln Arg Pro Phe Glu Arg Ser
                325                 330                 335     
Asp Phe Ser Asp Ser Ile Lys Ile Gln Thr Pro Glu Leu Gly Glu Val
            340                 345                 350         
Phe Gln Asn Lys Asp Ser Asp Tyr Leu Lys Asn Asp Asn Pro Glu Glu
        355                 360                 365             
His Leu Lys Thr Ser Gly Leu Ala Gly Glu Pro Glu Gly Glu Leu Ser
    370                 375                 380                 
Lys Glu Asp His Glu Asn Thr Glu Lys Tyr Met Gly Thr Glu Ser Gln
385                 390                 395                 400 
Gly Ser Ala Ala Ala Glu Pro Glu Asp Asp Ser Phe His Trp Thr Pro
                405                 410                 415     
His Thr Ser Val Glu Pro Gly His Ser Asp Lys Arg Glu Asp Leu Leu
            420                 425                 430         
Ile Ile Ser Ser Phe Phe Lys Glu Gln Gln Ser Leu Gln Arg Phe Gln
        435                 440                 445             
Lys Tyr Phe Asn Val His Glu Leu Glu Ala Leu Leu Gln Glu Met Ser
    450                 455                 460                 
Ser Lys Leu Lys Ser Ala Gln Gln Glu Ser Leu Pro Tyr Asn Met Glu
465                 470                 475                 480 
Lys Val Leu Asp Lys Val Phe Arg Ala Ser Glu Ser Gln Ile Leu Ser
                485                 490                 495     
Ile Ala Glu Lys Met Leu Asp Thr Arg Val Ala Glu Asn Arg Asp Leu
            500                 505                 510         
Gly Met Asn Glu Asn Asn Ile Phe Glu Glu Ala Ala Val Leu Asp Asp
        515                 520                 525             
Ile Gln Asp Leu Ile Tyr Phe Val Arg Tyr Lys Arg Ser Thr Ala Glu
    530                 535                 540                 
Glu Thr Ala Thr Leu Val Met Ala Pro Pro Leu Glu Glu Gly Leu Gly
545                 550                 555                 560 
Gly Ala Met Glu Glu Met Gln Pro Leu His Glu Asp Asn Phe Ser Arg
                565                 570                 575     
Glu Lys Thr Ala Glu Leu Asn Val Gln Val Pro Glu Glu Pro Thr His
            580                 585                 590         
Leu Asp Gln Arg Val Ile Gly Asp Thr His Ala Ser Glu Val Ser Gln
        595                 600                 605             
Lys Pro Asn Thr Glu Lys Asp Leu Asp Pro Gly Pro Val Thr Thr Glu
    610                 615                 620                 
Asp Thr Pro Met Asp Ala Ile Asp Ala Asn Lys Gln Pro Glu Thr Ala
625                 630                 635                 640 
Ala Glu Glu Pro Ala Ser Val Thr Pro Leu Glu Asn Ala Ile Leu Leu
                645                 650                 655     
Ile Tyr Ser Phe Met Phe Tyr Leu Thr Lys Ser Leu Val Ala Thr Leu
            660                 665                 670         
Pro Asp Asp Val Gln Pro Gly Pro Asp Phe Tyr Gly Leu Pro Trp Lys
        675                 680                 685             
Pro Val Phe Ile Thr Ala Phe Leu Gly Ile Ala Ser Phe Ala Ile Phe
    690                 695                 700                 
Leu Trp Arg Thr Val Leu Val Val Lys Asp Arg Val Tyr Gln Val Thr
705                 710                 715                 720 
Glu Gln Gln Ile Ser Glu Lys Leu Lys Thr Ile Met Lys Glu Asn Thr
                725                 730                 735     
Glu Leu Val Gln Lys Leu Ser Asn Tyr Glu Gln Lys Ile Lys Glu Ser
            740                 745                 750         
Lys Lys His Val Gln Glu Thr Arg Lys Gln Asn Met Ile Leu Ser Asp
        755                 760                 765             
Glu Ala Ile Lys Tyr Lys Asp Lys Ile Lys Thr Leu Glu Lys Asn Gln
    770                 775                 780                 
Glu Ile Leu Asp Asp Thr Ala Lys Asn Leu Arg Val Met Leu Glu Ser
785                 790                 795                 800 
Glu Arg Glu Gln Asn Val Lys Asn Gln Asp Leu Leu Gln Gln Glu Ile
                805                 810                 815     
Glu Asp Trp Ser Lys Leu His Ala Glu Leu Ser Glu Gln Ile Lys Ser
            820                 825                 830         
Phe Glu Lys Ser Gln Lys Asp Leu Glu Val Ala Leu Thr His Lys Asp
        835                 840                 845             
Asp Asn Ile Asn Ala Leu Thr Asn Cys Ile Thr Gln Leu Asn Leu Leu
    850                 855                 860                 
Glu Cys Glu Ser Glu Ser Glu Gly Gln Asn Lys Gly Gly Asn Asp Ser
865                 870                 875                 880 
Asp Glu Leu Ala Asn Gly Glu Val Gly Gly Asp Arg Asn Glu Lys Met
                885                 890                 895     
Lys Asn Gln Ile Lys Gln Met Met Asp Val Ser Arg Thr Gln Thr Ala
            900                 905                 910         
Ile Ser Val Val Glu Glu Asp Leu Lys Leu Leu Gln Leu Lys Leu Arg
        915                 920                 925             
Ala Ser Val Ser Thr Lys Cys Asn Leu Glu Asp Gln Val
    930                 935                 940     


<210> 6940
<211> 1907
<212> PRT
<213> Homo sapiens

<400> 6940
Met Ala Ala Ala Pro Gly Leu Leu Val Trp Leu Leu Val Leu Arg Leu
 1               5                  10                  15      
Pro Trp Arg Val Pro Gly Gln Leu Asp Pro Ser Thr Gly Arg Arg Phe
            20                  25                  30          
Ser Glu His Lys Leu Cys Ala Asp Asp Glu Cys Ser Met Leu Met Tyr
        35                  40                  45              
Arg Gly Glu Ala Leu Glu Asp Phe Thr Gly Pro Asp Cys Arg Phe Val
    50                  55                  60                  
Asn Phe Lys Lys Gly Asp Pro Val Tyr Val Tyr Tyr Lys Leu Ala Arg
65                  70                  75                  80  
Gly Trp Pro Glu Val Trp Ala Gly Ser Val Gly Arg Thr Phe Gly Tyr
                85                  90                  95      
Phe Pro Lys Asp Leu Ile Gln Val Val His Glu Tyr Thr Lys Glu Glu
            100                 105                 110         
Leu Gln Val Pro Thr Asp Glu Thr Asp Phe Val Cys Phe Asp Gly Gly
        115                 120                 125             
Arg Asp Asp Phe His Asn Tyr Asn Val Glu Glu Leu Leu Gly Phe Leu
    130                 135                 140                 
Glu Leu Tyr Asn Ser Ala Ala Thr Asp Ser Glu Lys Ala Val Glu Lys
145                 150                 155                 160 
Thr Leu Gln Asp Met Glu Lys Asn Pro Glu Leu Ser Lys Glu Arg Glu
                165                 170                 175     
Pro Glu Pro Glu Pro Val Glu Ala Asn Ser Glu Glu Ser Asp Ser Val
            180                 185                 190         
Phe Ser Glu Asn Thr Glu Asp Leu Gln Glu Gln Phe Thr Thr Gln Lys
        195                 200                 205             
His His Ser His Ala Asn Ser Gln Ala Asn His Ala Gln Gly Glu Gln
    210                 215                 220                 
Ala Ser Phe Glu Ser Phe Glu Glu Met Leu Gln Asp Lys Leu Lys Val
225                 230                 235                 240 
Pro Glu Ser Glu Asn Asn Lys Thr Ser Asn Ser Ser Gln Val Ser Asn
                245                 250                 255     
Glu Gln Asp Lys Ile Asp Ala Tyr Lys Leu Leu Lys Lys Glu Met Thr
            260                 265                 270         
Leu Asp Leu Lys Thr Lys Phe Gly Ser Thr Ala Asp Ala Leu Val Ser
        275                 280                 285             
Asp Asp Glu Thr Thr Arg Leu Val Thr Ser Leu Glu Asp Asp Phe Asp
    290                 295                 300                 
Glu Glu Leu Asp Thr Glu Tyr Tyr Ala Val Gly Lys Glu Asp Glu Glu
305                 310                 315                 320 
Asn Gln Glu Asp Phe Asp Glu Leu Pro Leu Leu Thr Phe Thr Asp Gly
                325                 330                 335     
Glu Asp Met Lys Thr Pro Ala Lys Ser Gly Val Glu Lys Tyr Pro Thr
            340                 345                 350         
Asp Lys Glu Gln Asn Ser Asn Glu Glu Asp Lys Val Gln Leu Thr Val
        355                 360                 365             
Pro Pro Gly Ile Lys Asn Asp Asp Lys Asn Ile Leu Thr Thr Trp Gly
    370                 375                 380                 
Asp Thr Ile Phe Ser Ile Val Thr Gly Gly Glu Glu Thr Arg Asp Thr
385                 390                 395                 400 
Met Asp Leu Glu Ser Ser Ser Ser Glu Glu Glu Lys Glu Asp Asp Asp
                405                 410                 415     
Asp Ala Leu Val Pro Asp Ser Lys Gln Gly Lys Pro Gln Ser Ala Thr
            420                 425                 430         
Asp Tyr Ser Asp Pro Asp Asn Val Asp Asp Gly Leu Phe Ile Val Asp
        435                 440                 445             
Ile Pro Lys Thr Asn Asn Asp Lys Glu Val Asn Ala Glu His His Ile
    450                 455                 460                 
Lys Gly Lys Gly Arg Gly Val Gln Glu Ser Lys Arg Gly Leu Val Gln
465                 470                 475                 480 
Asp Lys Thr Glu Leu Glu Asp Glu Asn Gln Glu Gly Met Thr Val His
                485                 490                 495     
Ser Ser Val His Ser Asn Asn Leu Asn Ser Met Pro Ala Ala Glu Lys
            500                 505                 510         
Gly Lys Asp Thr Leu Lys Ser Ala Tyr Asp Asp Thr Glu Asn Asp Leu
        515                 520                 525             
Lys Gly Ala Ala Ile His Ile Ser Lys Gly Met Leu His Glu Glu Lys
    530                 535                 540                 
Pro Gly Glu Gln Ile Leu Glu Gly Gly Ser Glu Ser Glu Ser Ala Gln
545                 550                 555                 560 
Lys Ala Ala Gly Asn Gln Met Asn Asp Arg Lys Ile Gln Gln Glu Ser
                565                 570                 575     
Leu Gly Ser Ala Pro Leu Met Gly Asp Asp His Pro Asn Ala Ser Arg
            580                 585                 590         
Asp Ser Val Glu Gly Asp Ala Leu Val Asn Gly Ala Lys Leu His Thr
        595                 600                 605             
Leu Ser Val Glu His Gln Arg Glu Glu Leu Lys Glu Glu Leu Val Leu
    610                 615                 620                 
Lys Thr Gln Asn Gln Pro Arg Phe Ser Ser Pro Asp Glu Ile Asp Leu
625                 630                 635                 640 
Pro Arg Glu Leu Glu Asp Glu Val Pro Ile Leu Gly Arg Asn Leu Pro
                645                 650                 655     
Trp Gln Gln Glu Arg Asp Val Ala Ala Thr Ala Ser Lys Gln Met Ser
            660                 665                 670         
Glu Lys Ile Arg Leu Ser Glu Gly Glu Ala Lys Glu Asp Ser Leu Asp
        675                 680                 685             
Glu Glu Phe Phe His His Lys Ala Met Gln Gly Thr Glu Val Gly Gln
    690                 695                 700                 
Thr Asp Gln Thr Asp Ser Thr Gly Gly Pro Ala Phe Leu Ser Lys Val
705                 710                 715                 720 
Glu Glu Asp Asp Tyr Pro Ser Glu Glu Leu Leu Glu Asp Glu Asn Ala
                725                 730                 735     
Ile Asn Ala Lys Arg Ser Lys Glu Lys Asn Pro Gly Asn Gln Gly Arg
            740                 745                 750         
Gln Phe Asp Val Asn Leu Gln Val Pro Asp Arg Ala Val Leu Gly Thr
        755                 760                 765             
Ile His Pro Asp Pro Glu Ile Glu Glu Ser Lys Gln Glu Thr Ser Met
    770                 775                 780                 
Ile Leu Asp Ser Glu Lys Thr Ser Glu Thr Ala Ala Lys Gly Val Asn
785                 790                 795                 800 
Thr Gly Gly Arg Glu Pro Asn Thr Met Val Glu Lys Glu Arg Pro Leu
                805                 810                 815     
Ala Asp Lys Lys Ala Gln Arg Pro Phe Glu Arg Ser Asp Phe Ser Asp
            820                 825                 830         
Ser Ile Lys Ile Gln Thr Pro Glu Leu Gly Glu Val Phe Gln Asn Lys
        835                 840                 845             
Asp Ser Asp Tyr Leu Lys Asn Asp Asn Pro Glu Glu His Leu Lys Thr
    850                 855                 860                 
Ser Gly Leu Ala Gly Glu Pro Glu Gly Glu Leu Ser Lys Glu Asp His
865                 870                 875                 880 
Glu Asn Thr Glu Lys Tyr Met Gly Thr Glu Ser Gln Gly Ser Ala Ala
                885                 890                 895     
Ala Glu Pro Glu Asp Asp Ser Phe His Trp Thr Pro His Thr Ser Val
            900                 905                 910         
Glu Pro Gly His Ser Asp Lys Arg Glu Asp Leu Leu Ile Ile Ser Ser
        915                 920                 925             
Phe Phe Lys Glu Gln Gln Ser Leu Gln Arg Phe Gln Lys Tyr Phe Asn
    930                 935                 940                 
Val His Glu Leu Glu Ala Leu Leu Gln Glu Met Ser Ser Lys Leu Lys
945                 950                 955                 960 
Ser Ala Gln Gln Glu Ser Leu Pro Tyr Asn Met Glu Lys Val Leu Asp
                965                 970                 975     
Lys Val Phe Arg Ala Ser Glu Ser Gln Ile Leu Ser Ile Ala Glu Lys
            980                 985                 990         
Met Leu Asp Thr Arg Val Ala Glu Asn Arg Asp Leu Gly Met Asn Glu
        995                 1000                1005            
Asn Asn Ile Phe Glu Glu Ala Ala Val Leu Asp Asp Ile Gln Asp Leu
    1010                1015                1020                
Ile Tyr Phe Val Arg Tyr Lys His Ser Thr Ala Glu Glu Thr Ala Thr
1025                1030                1035                1040
Leu Val Met Ala Pro Pro Leu Glu Glu Gly Leu Gly Gly Ala Met Glu
                1045                1050                1055    
Glu Met Gln Pro Leu His Glu Asp Asn Phe Ser Arg Glu Lys Thr Ala
            1060                1065                1070        
Glu Leu Asn Val Gln Val Pro Glu Glu Pro Thr His Leu Asp Gln Arg
        1075                1080                1085            
Val Ile Gly Asp Thr His Ala Ser Glu Val Ser Gln Lys Pro Asn Thr
    1090                1095                1100                
Glu Lys Asp Leu Asp Pro Gly Pro Val Thr Thr Glu Asp Thr Pro Met
1105                1110                1115                1120
Asp Ala Ile Asp Ala Asn Lys Gln Pro Glu Thr Ala Ala Glu Glu Pro
                1125                1130                1135    
Ala Ser Val Thr Pro Leu Glu Asn Ala Ile Leu Leu Ile Tyr Ser Phe
            1140                1145                1150        
Met Phe Tyr Leu Thr Lys Ser Leu Val Ala Thr Leu Pro Asp Asp Val
        1155                1160                1165            
Gln Pro Gly Pro Asp Phe Tyr Gly Leu Pro Trp Lys Pro Val Phe Ile
    1170                1175                1180                
Thr Ala Phe Leu Gly Ile Ala Ser Phe Ala Ile Phe Leu Trp Arg Thr
1185                1190                1195                1200
Val Leu Val Val Lys Asp Arg Val Tyr Gln Val Thr Glu Gln Gln Ile
                1205                1210                1215    
Ser Glu Lys Leu Lys Thr Ile Met Lys Glu Asn Thr Glu Leu Val Gln
            1220                1225                1230        
Lys Leu Ser Asn Tyr Glu Gln Lys Ile Lys Glu Ser Lys Lys His Val
        1235                1240                1245            
Gln Glu Thr Arg Lys Gln Asn Met Ile Leu Ser Asp Glu Ala Ile Lys
    1250                1255                1260                
Tyr Lys Asp Lys Ile Lys Thr Leu Glu Lys Asn Gln Glu Ile Leu Asp
1265                1270                1275                1280
Asp Thr Ala Lys Asn Leu Arg Val Met Leu Glu Ser Glu Arg Glu Gln
                1285                1290                1295    
Asn Val Lys Asn Gln Asp Leu Ile Ser Glu Asn Lys Lys Ser Ile Glu
            1300                1305                1310        
Lys Leu Lys Asp Val Ile Ser Met Asn Ala Ser Glu Phe Ser Glu Val
        1315                1320                1325            
Gln Ile Ala Leu Asn Glu Ala Lys Leu Ser Glu Glu Lys Val Lys Ser
    1330                1335                1340                
Glu Cys His Arg Val Gln Glu Glu Asn Ala Arg Leu Lys Lys Lys Lys
1345                1350                1355                1360
Glu Gln Leu Gln Gln Glu Ile Glu Asp Trp Ser Lys Leu His Ala Glu
                1365                1370                1375    
Leu Ser Glu Gln Ile Lys Ser Phe Glu Lys Ser Gln Lys Asp Leu Glu
            1380                1385                1390        
Val Ala Leu Thr His Lys Asp Asp Asn Ile Asn Ala Leu Thr Asn Cys
        1395                1400                1405            
Ile Thr Gln Leu Asn Leu Leu Glu Cys Glu Ser Glu Ser Glu Gly Gln
    1410                1415                1420                
Asn Lys Gly Gly Asn Asp Ser Asp Glu Leu Ala Asn Gly Glu Val Gly
1425                1430                1435                1440
Gly Asp Arg Asn Glu Lys Met Lys Asn Gln Ile Lys Gln Met Met Asp
                1445                1450                1455    
Val Ser Arg Thr Gln Thr Ala Ile Ser Val Val Glu Glu Asp Leu Lys
            1460                1465                1470        
Leu Leu Gln Leu Lys Leu Arg Ala Ser Val Ser Thr Lys Cys Asn Leu
        1475                1480                1485            
Glu Asp Gln Val Lys Lys Leu Glu Asp Asp Arg Asn Ser Leu Gln Ala
    1490                1495                1500                
Ala Lys Ala Gly Leu Glu Asp Glu Cys Lys Thr Leu Arg Gln Lys Val
1505                1510                1515                1520
Glu Ile Leu Asn Glu Leu Tyr Gln Gln Lys Glu Met Ala Leu Gln Lys
                1525                1530                1535    
Lys Leu Ser Gln Glu Glu Tyr Glu Arg Gln Glu Arg Glu His Arg Leu
            1540                1545                1550        
Ser Ala Ala Asp Glu Lys Ala Val Ser Ala Ala Glu Glu Val Lys Thr
        1555                1560                1565            
Tyr Lys Arg Arg Ile Glu Glu Met Glu Asp Glu Leu Gln Lys Thr Glu
    1570                1575                1580                
Arg Ser Phe Lys Asn Gln Ile Ala Thr His Glu Lys Lys Ala His Glu
1585                1590                1595                1600
Asn Trp Leu Lys Ala Arg Ala Ala Glu Arg Ala Ile Ala Glu Glu Lys
                1605                1610                1615    
Arg Glu Ala Ala Asn Leu Arg His Lys Leu Leu Glu Leu Thr Gln Lys
            1620                1625                1630        
Met Ala Met Leu Gln Glu Glu Pro Val Ile Val Lys Pro Met Pro Gly
        1635                1640                1645            
Lys Pro Asn Thr Gln Asn Pro Pro Arg Arg Gly Pro Leu Ser Gln Asn
    1650                1655                1660                
Gly Ser Phe Gly Pro Ser Pro Val Ser Gly Gly Glu Cys Ser Pro Pro
1665                1670                1675                1680
Leu Thr Val Glu Pro Pro Val Arg Pro Leu Ser Ala Thr Leu Asn Arg
                1685                1690                1695    
Arg Asp Met Pro Arg Ser Glu Phe Gly Ser Val Asp Gly Pro Leu Pro
            1700                1705                1710        
His Pro Arg Trp Ser Ala Glu Ala Ser Gly Lys Pro Ser Pro Ser Asp
        1715                1720                1725            
Pro Gly Ser Gly Thr Ala Thr Met Met Asn Ser Ser Ser Arg Gly Ser
    1730                1735                1740                
Ser Pro Thr Arg Val Leu Asp Glu Gly Lys Val Asn Met Ala Pro Lys
1745                1750                1755                1760
Gly Pro Pro Pro Phe Pro Gly Val Pro Leu Met Ser Thr Pro Met Gly
                1765                1770                1775    
Gly Pro Val Pro Pro Pro Ile Arg Tyr Gly Pro Pro Pro Gln Leu Cys
            1780                1785                1790        
Gly Pro Phe Gly Pro Arg Pro Leu Pro Pro Pro Phe Gly Pro Gly Met
        1795                1800                1805            
Arg Pro Pro Leu Gly Leu Arg Glu Phe Ala Pro Gly Val Pro Pro Gly
    1810                1815                1820                
Arg Arg Asp Leu Pro Leu His Pro Arg Gly Phe Leu Pro Gly His Ala
1825                1830                1835                1840
Pro Phe Arg Pro Leu Gly Ser Leu Gly Pro Arg Glu Tyr Phe Ile Pro
                1845                1850                1855    
Gly Thr Arg Leu Pro Pro Pro Thr His Gly Pro Gln Glu Tyr Pro Pro
            1860                1865                1870        
Pro Pro Ala Val Arg Asp Leu Leu Pro Ser Gly Ser Arg Asp Glu Pro
        1875                1880                1885            
Pro Pro Ala Ser Gln Ser Thr Ser Gln Asp Cys Ser Gln Ala Leu Lys
    1890                1895                1900                
Gln Ser Pro
1905        


<210> 6941
<211> 1907
<212> PRT
<213> Homo sapiens

<400> 6941
Met Ala Ala Ala Pro Gly Leu Leu Val Trp Leu Leu Val Leu Arg Leu
 1               5                  10                  15      
Pro Trp Arg Val Pro Gly Gln Leu Asp Pro Ser Thr Gly Arg Arg Phe
            20                  25                  30          
Ser Glu His Lys Leu Cys Ala Asp Asp Glu Cys Ser Met Leu Met Tyr
        35                  40                  45              
Arg Gly Glu Ala Leu Glu Asp Phe Thr Gly Pro Asp Cys Arg Phe Val
    50                  55                  60                  
Asn Phe Lys Lys Gly Asp Pro Val Tyr Val Tyr Tyr Lys Leu Ala Arg
65                  70                  75                  80  
Gly Trp Pro Glu Val Trp Ala Gly Ser Val Gly Arg Thr Phe Gly Tyr
                85                  90                  95      
Phe Pro Lys Asp Leu Ile Gln Val Val His Glu Tyr Thr Lys Glu Glu
            100                 105                 110         
Leu Gln Val Pro Thr Asp Glu Thr Asp Phe Val Cys Phe Asp Gly Gly
        115                 120                 125             
Arg Asp Asp Phe His Asn Tyr Asn Val Glu Glu Leu Leu Gly Phe Leu
    130                 135                 140                 
Glu Leu Tyr Asn Ser Ala Ala Thr Asp Ser Glu Lys Ala Val Glu Lys
145                 150                 155                 160 
Thr Leu Gln Asp Met Glu Lys Asn Pro Glu Leu Ser Lys Glu Arg Glu
                165                 170                 175     
Pro Glu Pro Glu Pro Val Glu Ala Asn Ser Glu Glu Ser Asp Ser Val
            180                 185                 190         
Phe Ser Glu Asn Thr Glu Asp Leu Gln Glu Gln Phe Thr Thr Gln Lys
        195                 200                 205             
His His Ser His Ala Asn Ser Gln Ala Asn His Ala Gln Gly Glu Gln
    210                 215                 220                 
Ala Ser Phe Glu Ser Phe Glu Glu Met Leu Gln Asp Lys Leu Lys Val
225                 230                 235                 240 
Pro Glu Ser Glu Asn Asn Lys Thr Ser Asn Ser Ser Gln Val Ser Asn
                245                 250                 255     
Glu Gln Asp Lys Ile Asp Ala Tyr Lys Leu Leu Lys Lys Glu Met Thr
            260                 265                 270         
Leu Asp Leu Lys Thr Lys Phe Gly Ser Thr Ala Asp Ala Leu Val Ser
        275                 280                 285             
Asp Asp Glu Thr Thr Arg Leu Val Thr Ser Leu Glu Asp Asp Phe Asp
    290                 295                 300                 
Glu Glu Leu Asp Thr Glu Tyr Tyr Ala Val Gly Lys Glu Asp Glu Glu
305                 310                 315                 320 
Asn Gln Glu Asp Phe Asp Glu Leu Pro Leu Leu Thr Phe Thr Asp Gly
                325                 330                 335     
Glu Asp Met Lys Thr Pro Ala Lys Ser Gly Val Glu Lys Tyr Pro Thr
            340                 345                 350         
Asp Lys Glu Gln Asn Ser Asn Glu Glu Asp Lys Val Gln Leu Thr Val
        355                 360                 365             
Pro Pro Gly Ile Lys Asn Asp Asp Lys Asn Ile Leu Thr Thr Trp Gly
    370                 375                 380                 
Asp Thr Ile Phe Ser Ile Val Thr Gly Gly Glu Glu Thr Arg Asp Thr
385                 390                 395                 400 
Met Asp Leu Glu Ser Ser Ser Ser Glu Glu Glu Lys Glu Asp Asp Asp
                405                 410                 415     
Asp Ala Leu Val Pro Asp Ser Lys Gln Gly Lys Pro Gln Ser Ala Thr
            420                 425                 430         
Asp Tyr Ser Asp Pro Asp Asn Val Asp Asp Gly Leu Phe Ile Val Asp
        435                 440                 445             
Ile Pro Lys Thr Asn Asn Asp Lys Glu Val Asn Ala Glu His His Ile
    450                 455                 460                 
Lys Gly Lys Gly Arg Gly Val Gln Glu Ser Lys Arg Gly Leu Val Gln
465                 470                 475                 480 
Asp Lys Thr Glu Leu Glu Asp Glu Asn Gln Glu Gly Met Thr Val His
                485                 490                 495     
Ser Ser Val His Ser Asn Asn Leu Asn Ser Met Pro Ala Ala Glu Lys
            500                 505                 510         
Gly Lys Asp Thr Leu Lys Ser Ala Tyr Asp Asp Thr Glu Asn Asp Leu
        515                 520                 525             
Lys Gly Ala Ala Ile His Ile Ser Lys Gly Met Leu His Glu Glu Lys
    530                 535                 540                 
Pro Gly Glu Gln Ile Leu Glu Gly Gly Ser Glu Ser Glu Ser Ala Gln
545                 550                 555                 560 
Lys Ala Ala Gly Asn Gln Met Asn Asp Arg Lys Ile Gln Gln Glu Ser
                565                 570                 575     
Leu Gly Ser Ala Pro Leu Met Gly Asp Asp His Pro Asn Ala Ser Arg
            580                 585                 590         
Asp Ser Val Glu Gly Asp Ala Leu Val Asn Gly Ala Lys Leu His Thr
        595                 600                 605             
Leu Ser Val Glu His Gln Arg Glu Glu Leu Lys Glu Glu Leu Val Leu
    610                 615                 620                 
Lys Thr Gln Asn Gln Pro Arg Phe Ser Ser Pro Asp Glu Ile Asp Leu
625                 630                 635                 640 
Pro Arg Glu Leu Glu Asp Glu Val Pro Ile Leu Gly Arg Asn Leu Pro
                645                 650                 655     
Trp Gln Gln Glu Arg Asp Val Ala Ala Thr Ala Ser Lys Gln Met Ser
            660                 665                 670         
Glu Lys Ile Arg Leu Ser Glu Gly Glu Ala Lys Glu Asp Ser Leu Asp
        675                 680                 685             
Glu Glu Phe Phe His His Lys Ala Met Gln Gly Thr Glu Val Gly Gln
    690                 695                 700                 
Thr Asp Gln Thr Asp Ser Thr Gly Gly Pro Ala Phe Leu Ser Lys Val
705                 710                 715                 720 
Glu Glu Asp Asp Tyr Pro Ser Glu Glu Leu Leu Glu Asp Glu Asn Ala
                725                 730                 735     
Ile Asn Ala Lys Arg Ser Lys Glu Lys Asn Pro Gly Asn Gln Gly Arg
            740                 745                 750         
Gln Phe Asp Val Asn Leu Gln Val Pro Asp Arg Ala Val Leu Gly Thr
        755                 760                 765             
Ile His Pro Asp Pro Glu Ile Glu Glu Ser Lys Gln Glu Thr Ser Met
    770                 775                 780                 
Ile Leu Asp Ser Glu Lys Thr Ser Glu Thr Ala Ala Lys Gly Val Asn
785                 790                 795                 800 
Thr Gly Gly Arg Glu Pro Asn Thr Met Val Glu Lys Glu Arg Pro Leu
                805                 810                 815     
Ala Asp Lys Lys Ala Gln Arg Pro Phe Glu Arg Ser Asp Phe Ser Asp
            820                 825                 830         
Ser Ile Lys Ile Gln Thr Pro Glu Leu Gly Glu Val Phe Gln Asn Lys
        835                 840                 845             
Asp Ser Asp Tyr Leu Lys Asn Asp Asn Pro Glu Glu His Leu Lys Thr
    850                 855                 860                 
Ser Gly Leu Ala Gly Glu Pro Glu Gly Glu Leu Ser Lys Glu Asp His
865                 870                 875                 880 
Glu Asn Thr Glu Lys Tyr Met Gly Thr Glu Ser Gln Gly Ser Ala Ala
                885                 890                 895     
Ala Glu Pro Glu Asp Asp Ser Phe His Trp Thr Pro His Thr Ser Val
            900                 905                 910         
Glu Pro Gly His Ser Asp Lys Arg Glu Asp Leu Leu Ile Ile Ser Ser
        915                 920                 925             
Phe Phe Lys Glu Gln Gln Ser Leu Gln Arg Phe Gln Lys Tyr Phe Asn
    930                 935                 940                 
Val His Glu Leu Glu Ala Leu Leu Gln Glu Met Ser Ser Lys Leu Lys
945                 950                 955                 960 
Ser Ala Gln Gln Glu Ser Leu Pro Tyr Asn Met Glu Lys Val Leu Asp
                965                 970                 975     
Lys Val Phe Arg Ala Ser Glu Ser Gln Ile Leu Ser Ile Ala Glu Lys
            980                 985                 990         
Met Leu Asp Thr Arg Val Ala Glu Asn Arg Asp Leu Gly Met Asn Glu
        995                 1000                1005            
Asn Asn Ile Phe Glu Glu Ala Ala Val Leu Asp Asp Ile Gln Asp Leu
    1010                1015                1020                
Ile Tyr Phe Val Arg Tyr Lys His Ser Thr Ala Glu Glu Thr Ala Thr
1025                1030                1035                1040
Leu Val Met Ala Pro Pro Leu Glu Glu Gly Leu Gly Gly Ala Met Glu
                1045                1050                1055    
Glu Met Gln Pro Leu His Glu Asp Asn Phe Ser Arg Glu Lys Thr Ala
            1060                1065                1070        
Glu Leu Asn Val Gln Val Pro Glu Glu Pro Thr His Leu Asp Gln Arg
        1075                1080                1085            
Val Ile Gly Asp Thr His Ala Ser Glu Val Ser Gln Lys Pro Asn Thr
    1090                1095                1100                
Glu Lys Asp Leu Asp Pro Gly Pro Val Thr Thr Glu Asp Thr Pro Met
1105                1110                1115                1120
Asp Ala Ile Asp Ala Asn Gln Gln Pro Glu Thr Ala Ala Glu Glu Pro
                1125                1130                1135    
Ala Ser Val Thr Pro Leu Glu Asn Ala Ile Leu Leu Ile Tyr Ser Phe
            1140                1145                1150        
Met Phe Tyr Leu Thr Lys Ser Leu Val Ala Thr Leu Pro Asp Asp Val
        1155                1160                1165            
Gln Pro Gly Pro Asp Phe Tyr Gly Leu Pro Trp Lys Pro Val Phe Ile
    1170                1175                1180                
Thr Ala Phe Leu Gly Ile Ala Ser Phe Ala Ile Phe Leu Trp Arg Thr
1185                1190                1195                1200
Val Leu Val Val Lys Asp Arg Val Tyr Gln Val Thr Glu Gln Gln Ile
                1205                1210                1215    
Ser Glu Lys Leu Lys Thr Ile Met Lys Glu Asn Thr Glu Leu Val Gln
            1220                1225                1230        
Lys Leu Ser Asn Tyr Glu Gln Lys Ile Lys Glu Ser Lys Lys His Val
        1235                1240                1245            
Gln Glu Thr Arg Lys Gln Asn Met Ile Leu Ser Asp Glu Ala Ile Lys
    1250                1255                1260                
Tyr Lys Asp Lys Ile Lys Thr Leu Glu Lys Asn Gln Glu Ile Leu Asp
1265                1270                1275                1280
Asp Thr Ala Lys Asn Leu Arg Val Met Leu Glu Ser Glu Arg Glu Gln
                1285                1290                1295    
Asn Val Lys Asn Gln Asp Leu Ile Ser Glu Asn Lys Lys Ser Ile Glu
            1300                1305                1310        
Lys Leu Lys Asp Val Ile Ser Met Asn Ala Ser Glu Phe Ser Glu Val
        1315                1320                1325            
Gln Ile Ala Leu Asn Glu Ala Lys Leu Ser Glu Glu Lys Val Lys Ser
    1330                1335                1340                
Glu Cys His Arg Val Gln Glu Glu Asn Ala Arg Leu Lys Lys Lys Lys
1345                1350                1355                1360
Glu Gln Leu Gln Gln Glu Ile Glu Asp Trp Ser Lys Leu His Ala Glu
                1365                1370                1375    
Leu Ser Glu Gln Ile Lys Ser Phe Glu Lys Ser Gln Lys Asp Leu Glu
            1380                1385                1390        
Val Ala Leu Thr His Lys Asp Asp Asn Ile Asn Ala Leu Thr Asn Cys
        1395                1400                1405            
Ile Thr Gln Leu Asn Leu Leu Glu Cys Glu Ser Glu Ser Glu Gly Gln
    1410                1415                1420                
Asn Lys Gly Gly Asn Asp Ser Asp Glu Leu Ala Asn Gly Glu Val Gly
1425                1430                1435                1440
Gly Asp Arg Asn Glu Lys Met Lys Asn Gln Ile Lys Gln Met Met Asp
                1445                1450                1455    
Val Ser Arg Thr Gln Thr Ala Ile Ser Val Val Glu Glu Asp Leu Lys
            1460                1465                1470        
Leu Leu Gln Leu Lys Leu Arg Ala Ser Val Ser Thr Lys Cys Asn Leu
        1475                1480                1485            
Glu Asp Gln Val Lys Lys Leu Glu Asp Asp Arg Asn Ser Leu Gln Ala
    1490                1495                1500                
Ala Lys Ala Gly Leu Glu Asp Glu Cys Lys Thr Leu Arg Gln Lys Val
1505                1510                1515                1520
Glu Ile Leu Asn Glu Leu Tyr Gln Gln Lys Glu Met Ala Leu Gln Lys
                1525                1530                1535    
Lys Leu Ser Gln Glu Glu Tyr Glu Arg Gln Glu Arg Glu His Arg Leu
            1540                1545                1550        
Ser Ala Ala Asp Glu Lys Ala Val Ser Ala Ala Glu Glu Val Lys Thr
        1555                1560                1565            
Tyr Lys Arg Arg Ile Glu Glu Met Glu Asp Glu Leu Gln Lys Thr Glu
    1570                1575                1580                
Arg Ser Phe Lys Asn Gln Ile Ala Thr His Glu Lys Lys Ala His Glu
1585                1590                1595                1600
Asn Trp Leu Lys Ala Arg Ala Ala Glu Arg Ala Ile Ala Glu Glu Lys
                1605                1610                1615    
Arg Glu Ala Ala Asn Leu Arg His Lys Leu Leu Glu Leu Thr Gln Lys
            1620                1625                1630        
Met Ala Met Leu Gln Glu Glu Pro Val Ile Val Lys Pro Met Pro Gly
        1635                1640                1645            
Lys Pro Asn Thr Gln Asn Pro Pro Arg Arg Gly Pro Leu Ser Gln Asn
    1650                1655                1660                
Gly Ser Phe Gly Pro Ser Pro Val Ser Gly Gly Glu Cys Ser Pro Pro
1665                1670                1675                1680
Leu Thr Val Glu Pro Pro Val Arg Pro Leu Ser Ala Thr Leu Asn Arg
                1685                1690                1695    
Arg Asp Met Pro Arg Ser Glu Phe Gly Ser Val Asp Gly Pro Leu Pro
            1700                1705                1710        
His Pro Arg Trp Ser Ala Glu Ala Ser Gly Lys Pro Ser Pro Ser Asp
        1715                1720                1725            
Pro Gly Ser Gly Thr Ala Thr Met Met Asn Ser Ser Ser Arg Gly Ser
    1730                1735                1740                
Ser Pro Thr Arg Val Leu Asp Glu Gly Lys Val Asn Met Ala Pro Lys
1745                1750                1755                1760
Gly Pro Pro Pro Phe Pro Gly Val Pro Leu Met Ser Thr Pro Met Gly
                1765                1770                1775    
Gly Pro Val Pro Pro Pro Ile Arg Tyr Gly Pro Pro Pro Gln Leu Cys
            1780                1785                1790        
Gly Pro Phe Gly Pro Arg Pro Leu Pro Pro Pro Phe Gly Pro Gly Met
        1795                1800                1805            
Arg Pro Pro Leu Gly Leu Arg Glu Phe Ala Pro Gly Val Pro Pro Gly
    1810                1815                1820                
Arg Arg Asp Leu Pro Leu His Pro Arg Gly Phe Leu Pro Gly His Ala
1825                1830                1835                1840
Pro Phe Arg Pro Leu Gly Ser Leu Gly Pro Arg Glu Tyr Phe Ile Pro
                1845                1850                1855    
Gly Thr Arg Leu Pro Pro Pro Thr His Gly Pro Gln Glu Tyr Pro Pro
            1860                1865                1870        
Pro Pro Ala Val Arg Asp Leu Leu Pro Ser Gly Ser Arg Asp Glu Pro
        1875                1880                1885            
Pro Pro Ala Ser Gln Ser Thr Ser Gln Asp Cys Ser Gln Ala Leu Lys
    1890                1895                1900                
Gln Ser Pro
1905        


<210> 6942
<211> 1419
<212> PRT
<213> Homo sapiens

<400> 6942
Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn Phe Pro Ser Val Gln Lys
 1               5                  10                  15      
Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser Asp Val Lys Phe Thr Val
            20                  25                  30          
Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys Leu Leu Glu Tyr Ser Gly
        35                  40                  45              
Leu Lys Lys Arg His Leu His Cys Ile Ser Phe Leu Val Pro Pro Pro
    50                  55                  60                  
Ala Gly Gly Thr Glu Glu Val Ala Thr Ile Arg Val Ser Gly Val Gly
65                  70                  75                  80  
Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys Val Leu Ile Gln Arg Gln
                85                  90                  95      
Gly Asn Gly Thr Phe Val Gln Thr Asp Lys Pro Leu Tyr Thr Pro Gly
            100                 105                 110         
Gln Gln Val Tyr Phe Arg Ile Val Thr Met Asp Ser Asn Phe Val Pro
        115                 120                 125             
Val Asn Asp Lys Val Ser Thr Ser Cys Ser Phe Ser Ile Gly Gln Asp
    130                 135                 140                 
Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro Glu Gln
145                 150                 155                 160 
Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met Leu Gly
                165                 170                 175     
Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr Phe Ser
            180                 185                 190         
Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val Glu Pro
        195                 200                 205             
Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile Cys Cys
    210                 215                 220                 
Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val Ser Val
225                 230                 235                 240 
Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg Glu Gln
                245                 250                 255     
Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys Thr Gly
            260                 265                 270         
Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile Gly Tyr
        275                 280                 285             
Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu Glu Gly
    290                 295                 300                 
Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser Pro Gln
305                 310                 315                 320 
Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His Pro Asn
                325                 330                 335     
Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp Ser Phe
            340                 345                 350         
Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn Gly Thr
        355                 360                 365             
Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro Phe Thr
    370                 375                 380                 
Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu Gly Lys
385                 390                 395                 400 
Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro Arg Tyr
                405                 410                 415     
Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr Thr Arg
            420                 425                 430         
Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys Gly Gln
        435                 440                 445             
Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp Ala Ser
    450                 455                 460                 
Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Val Arg Pro Gly Asn Gly
465                 470                 475                 480 
Asp Gly Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys
                485                 490                 495     
Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu
            500                 505                 510         
Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly
        515                 520                 525             
Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn
    530                 535                 540                 
Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu
545                 550                 555                 560 
Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg
                565                 570                 575     
Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser
            580                 585                 590         
Asn Arg Ser Val Ser Asn Cys Leu Leu Thr Glu Phe Thr Ile Asn Ser
        595                 600                 605             
Lys Arg Met Phe Cys Phe Asn Ser Leu Met Val Glu Phe Leu Gly Ser
    610                 615                 620                 
Ser Pro Cys Ser Trp Gly Arg Asp His Leu Asn Thr Tyr Phe Ser Asp
625                 630                 635                 640 
Ala Tyr Gln Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile Lys
                645                 650                 655     
Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala Met
            660                 665                 670         
Gly Val Phe Val Phe Ser Ile Ser Ser Ala Gly Gly Gly His Pro Glu
        675                 680                 685             
Ala Phe Glu Ser Ser Thr Pro Leu His Gln Ala Glu Asp Ser Gln Val
    690                 695                 700                 
Arg Gln Tyr Phe Pro Glu Thr Trp Leu Trp Asp Leu Phe Pro Ile Gly
705                 710                 715                 720 
Asn Ser Gly Lys Glu Ala Val His Val Thr Val Pro Asp Ala Ile Thr
                725                 730                 735     
Glu Trp Lys Ala Met Ser Phe Cys Thr Ser Gln Ser Arg Gly Phe Gly
            740                 745                 750         
Leu Ser Pro Thr Val Gly Leu Thr Ala Phe Lys Pro Phe Phe Val Asp
        755                 760                 765             
Leu Thr Leu Pro Tyr Ser Val Val Arg Gly Glu Ser Phe Arg Leu Thr
    770                 775                 780                 
Ala Thr Ile Phe Asn Tyr Leu Lys Asp Cys Ile Arg Val Gln Thr Asp
785                 790                 795                 800 
Leu Ala Lys Ser His Glu Tyr Gln Leu Glu Ser Trp Ala Asp Ser Gln
                805                 810                 815     
Thr Ser Ser Cys Leu Cys Ala Asp Asp Ala Lys Thr His His Trp Asn
            820                 825                 830         
Ile Thr Ala Val Lys Leu Ala Leu Val Cys Ser Ser Glu Gly Ser Pro
        835                 840                 845             
Gly Gly Thr Ala Arg Gly Leu Pro Ser Leu Ser Phe Ser Ala Ile Pro
    850                 855                 860                 
Pro Asp Val His Leu Cys Cys Phe Tyr Leu Cys Leu Ser Ser Ser Gln
865                 870                 875                 880 
Pro Glu Gly Val Leu Val Glu Lys Thr His Ser Ser Leu Leu Cys Pro
                885                 890                 895     
Lys Gly Lys Val Ala Ser Glu Ser Val Ser Leu Glu Leu Pro Val Asp
            900                 905                 910         
Ile Val Pro Asp Ser Thr Lys Ala Tyr Val Thr Val Leu Gly Asp Ile
        915                 920                 925             
Met Gly Thr Ala Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser
    930                 935                 940                 
Gly Cys Gly Glu Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val
945                 950                 955                 960 
Leu Gln Tyr Leu Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser
                965                 970                 975     
Arg Ala Val Gly Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr
            980                 985                 990         
Lys His Ser Asn Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn
        995                 1000                1005            
Gly Asn Thr Trp Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala
    1010                1015                1020                
Gln Lys Phe Ile Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys
1025                1030                1035                1040
Trp Met Ala Gly Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly
                1045                1050                1055    
Asn Leu Leu His Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser
            1060                1065                1070        
Leu Thr Ala Tyr Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val
        1075                1080                1085            
Asp Asp Pro Met Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala
    1090                1095                1100                
Thr Ser Thr Thr Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe
1105                1110                1115                1120
Ser Leu Ala Gly Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu
                1125                1130                1135    
Asp Gln Gln Ala Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys
            1140                1145                1150        
Pro Thr Pro Ser Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val
        1155                1160                1165            
Asp Val Glu Leu Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro
    1170                1175                1180                
Ser Leu Thr Gln Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp
1185                1190                1195                1200
Leu Ala Lys Gln His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp
                1205                1210                1215    
Thr Val Val Ala Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr
            1220                1225                1230        
Met Pro Ser Glu Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe
        1235                1240                1245            
Gln Arg Thr Phe Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln
    1250                1255                1260                
Asp Thr Leu Pro Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly
1265                1270                1275                1280
Gln Gly Cys Val Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro
                1285                1290                1295    
Pro Thr Asn Met Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala
            1300                1305                1310        
Arg Cys Glu Gln Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His
        1315                1320                1325            
Thr Ser Tyr Val Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu
    1330                1335                1340                
Val Lys Met Leu Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu
1345                1350                1355                1360
Val Arg Ser Phe Ile Pro His Cys Ile Gln Cys Asn Phe His Phe Thr
                1365                1370                1375    
Ser Lys Val Leu Phe His Leu Ser Ser Pro Gln Leu Ile Lys Asn Thr
            1380                1385                1390        
Gln Thr Tyr Thr Phe Thr Ile Ser Gln Ser Val Leu Val Thr Asn Leu
        1395                1400                1405            
Lys Pro Ala Thr Ile Lys Val Tyr Asp Tyr Tyr
    1410                1415                


<210> 6943
<211> 278
<212> PRT
<213> Homo sapiens

<400> 6943
Met Asp Ser Met Pro Glu Pro Ala Ser Arg Cys Leu Leu Leu Leu Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Ala Pro Glu Leu Gly Pro
            20                  25                  30          
Ser Gln Ala Gly Ala Glu Glu Asn Asp Trp Val Arg Leu Pro Ser Lys
        35                  40                  45              
Cys Glu Val Cys Lys Tyr Val Ala Val Glu Leu Lys Ser Ala Phe Glu
    50                  55                  60                  
Glu Thr Gly Lys Thr Lys Glu Val Ile Gly Thr Gly Tyr Gly Ile Leu
65                  70                  75                  80  
Asp Gln Lys Ala Ser Gly Val Lys Tyr Thr Lys Ser Asp Leu Arg Leu
                85                  90                  95      
Ile Glu Val Thr Glu Thr Ile Cys Lys Arg Leu Leu Asp Tyr Ser Leu
            100                 105                 110         
His Lys Glu Arg Thr Gly Ser Asn Arg Phe Ala Lys Gly Met Ser Glu
        115                 120                 125             
Thr Phe Glu Thr Leu His Asn Leu Val His Lys Gly Val Lys Val Val
    130                 135                 140                 
Met Asp Ile Pro Tyr Glu Leu Trp Asn Glu Thr Ser Ala Glu Val Ala
145                 150                 155                 160 
Asp Leu Lys Lys Gln Cys Asp Val Leu Val Glu Glu Phe Glu Glu Val
                165                 170                 175     
Ile Glu Asp Trp Tyr Arg Asn His Gln Glu Glu Asp Leu Thr Glu Phe
            180                 185                 190         
Leu Cys Ala Asn His Val Leu Lys Gly Lys Asp Thr Ser Cys Leu Ala
        195                 200                 205             
Glu Gln Trp Ser Gly Lys Lys Gly Asp Thr Ala Ala Leu Gly Gly Lys
    210                 215                 220                 
Lys Ser Lys Lys Lys Ser Ser Arg Ala Lys Ala Ala Gly Gly Arg Ser
225                 230                 235                 240 
Ser Ser Ser Lys Gln Arg Lys Glu Leu Gly Gly Leu Glu Gly Asp Pro
                245                 250                 255     
Ser Pro Glu Glu Asp Glu Gly Ile Gln Lys Ala Ser Pro Leu Thr His
            260                 265                 270         
Ser Pro Pro Asp Glu Leu
        275             


<210> 6944
<211> 348
<212> PRT
<213> Homo sapiens

<400> 6944
Met Ala Ala Thr Leu Gly Pro Leu Gly Ser Trp Gln Gln Trp Arg Arg
 1               5                  10                  15      
Cys Leu Ser Ala Arg Asp Gly Ser Arg Met Leu Leu Leu Leu Leu Leu
            20                  25                  30          
Leu Gly Ser Gly Gln Gly Pro Gln Gln Val Gly Ala Gly Gln Thr Phe
        35                  40                  45              
Glu Tyr Leu Lys Arg Glu His Ser Leu Ser Lys Pro Tyr Gln Gly Val
    50                  55                  60                  
Gly Thr Gly Ser Ser Ser Leu Trp Asn Leu Met Gly Asn Ala Met Val
65                  70                  75                  80  
Met Thr Gln Tyr Ile Arg Leu Thr Pro Asp Met Gln Ser Lys Gln Gly
                85                  90                  95      
Ala Leu Trp Asn Arg Val Pro Cys Phe Leu Arg Asp Trp Glu Leu Gln
            100                 105                 110         
Val His Phe Lys Ile His Gly Gln Gly Lys Lys Asn Leu His Gly Asp
        115                 120                 125             
Gly Leu Ala Ile Trp Tyr Thr Lys Asp Arg Met Gln Pro Gly Pro Val
    130                 135                 140                 
Phe Gly Asn Met Asp Lys Phe Val Gly Leu Gly Val Phe Val Asp Thr
145                 150                 155                 160 
Tyr Pro Asn Glu Glu Lys Gln Gln Glu Arg Val Phe Pro Tyr Ile Ser
                165                 170                 175     
Ala Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Glu Arg Asp Gly
            180                 185                 190         
Arg Pro Thr Glu Leu Gly Gly Cys Thr Ala Ile Val Arg Asn Leu His
        195                 200                 205             
Tyr Asp Thr Phe Leu Val Ile Arg Tyr Val Lys Arg His Leu Thr Ile
    210                 215                 220                 
Met Met Asp Ile Asp Gly Lys His Glu Trp Arg Asp Cys Ile Glu Val
225                 230                 235                 240 
Pro Gly Val Arg Leu Pro Arg Gly Tyr Tyr Phe Gly Thr Ser Ser Ile
                245                 250                 255     
Thr Gly Asp Leu Ser Asp Asn His Asp Val Ile Ser Leu Lys Leu Phe
            260                 265                 270         
Glu Leu Thr Val Glu Arg Thr Pro Glu Glu Glu Lys Leu His Arg Asp
        275                 280                 285             
Val Phe Leu Pro Ser Val Asp Asn Met Lys Leu Pro Glu Met Thr Ala
    290                 295                 300                 
Pro Leu Pro Pro Leu Ser Gly Leu Ala Leu Phe Leu Ile Val Phe Phe
305                 310                 315                 320 
Ser Leu Val Phe Ser Val Phe Ala Ile Val Ile Gly Ile Ile Leu Tyr
                325                 330                 335     
Asn Lys Trp Gln Glu Gln Ser Arg Lys Arg Phe Tyr
            340                 345             


<210> 6945
<211> 180
<212> PRT
<213> Homo sapiens

<400> 6945
Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val
 1               5                  10                  15      
Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys
            20                  25                  30          
Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser
        35                  40                  45              
Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu
    50                  55                  60                  
Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu
65                  70                  75                  80  
Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn
                85                  90                  95      
Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu
            100                 105                 110         
Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr
        115                 120                 125             
Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu
    130                 135                 140                 
Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro
145                 150                 155                 160 
Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu
                165                 170                 175     
Pro Cys Arg Phe
            180 


<210> 6946
<211> 481
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 189, 205, 244, 449
<223> Xaa = Any Amino Acid

<400> 6946
Met Trp Gly Arg Val His Val Lys Gly Cys Pro Gln Ile Gln Ala Thr
 1               5                  10                  15      
His Ser Leu Gly Leu Leu Ser Arg Phe His Gly Ser Ala Ser Thr Asp
            20                  25                  30          
Ser Glu Leu Glu Ala Lys Glu Ser Gly Ile Thr Gln Glu Leu Ile Lys
        35                  40                  45              
Ser Leu Tyr Pro Gln Gln Thr Arg Leu Cys Ala Trp Cys Trp Thr Cys
    50                  55                  60                  
Ile Ile Leu Val Gly Thr Asn Val Leu His Arg Leu Pro Leu His Leu
65                  70                  75                  80  
Ala Ser Gly His Ala Phe His Leu Trp Leu Ser Cys Ser Asn Pro Ala
                85                  90                  95      
Thr Leu Pro Arg Val Gly Glu Lys Lys Leu Val Lys Pro Val Leu Lys
            100                 105                 110         
Leu Met Leu Gln Val Ala Phe Phe Leu Leu Gly Phe Leu Ala Lys Val
        115                 120                 125             
Lys Gly Lys Lys Ala Thr Gln Asp Lys Ala Pro Ile Phe Val Thr Ala
    130                 135                 140                 
Pro Arg Ser Thr Phe Phe Asp Ser Ile Pro Cys Val Val Ala Gly Leu
145                 150                 155                 160 
Pro Ser Val Val Ser Ala Ser Gln Asn Val Gln Ile Pro Leu Ala Gly
                165                 170                 175     
Lys Phe Leu Leu Ser Thr Gln Leu Val Leu Val Ile Xaa Glu Asp Ser
            180                 185                 190         
His Ser Arg Lys Asn Thr Lys Asp Glu Ile Leu Lys Xaa Val Thr Phe
        195                 200                 205             
Gly Lys Lys Trp Pro Gln Ile Leu Ile Phe Leu Glu Gly Val Cys Ile
    210                 215                 220                 
Asn Arg Ser Arg Leu Val Thr Phe Lys Pro Gly Ala Phe Cys Pro Gly
225                 230                 235                 240 
Val Pro Val Xaa Pro Val Leu Leu Arg Tyr Pro Asn Thr Leu Asp Met
                245                 250                 255     
Ala Ile Trp Thr Trp Gln Gly Phe Thr Ala Leu Gln Ala Cys Met Leu
            260                 265                 270         
Thr Leu Ser Gln Leu Phe Thr Arg Val Glu Val Glu Phe Met Pro Val
        275                 280                 285             
Tyr Ile Pro Asn Asp Glu Glu Lys Lys Asp Pro Ile Leu Phe Ala Asn
    290                 295                 300                 
Thr Ala His Ile Asn Met Ala Asn Ala Leu Gly Val Pro Gly Thr Gly
305                 310                 315                 320 
His Thr Tyr Glu Gly Cys Arg Val Met Ile Ser Ala Gly Asn Leu Gln
                325                 330                 335     
Leu Pro Val Glu Ala Gly Leu Val Glu Phe Thr Asn Ile Ser Gln Lys
            340                 345                 350         
Leu Lys Leu Asp Arg Asp Asn Ile His Gln His Leu Asp Glu Tyr Ala
        355                 360                 365             
Ala Ile Ala Val Ala Ser Lys Gly Gly Lys Thr Gly Ile Glu Glu Phe
    370                 375                 380                 
Ser Ser Tyr Leu Lys Leu Pro Ile Ser Glu Pro Leu Arg Gln Pro Pro
385                 390                 395                 400 
Ala His Phe Gly Arg Asn Asn Asp Gly Asn Ile Asp Phe Arg Glu Tyr
                405                 410                 415     
Val Ile Gly Leu Lys Lys Ser Leu Gln Met Ser Phe Lys Leu Phe Asp
            420                 425                 430         
Leu Asp Ala Asp Gly Leu Ile Thr Glu Gln Glu Phe Ala Ala Ile Leu
        435                 440                 445             
Xaa Ala Ala Phe Gly His Pro Ala Tyr Pro Asn Leu Phe Asn Ser His
    450                 455                 460                 
Leu Asp Leu Gln Ala Ala Tyr Ile Tyr Ser Leu Pro Gln Lys Val Gln
465                 470                 475                 480 
Phe
    


<210> 6947
<211> 538
<212> PRT
<213> Homo sapiens

<400> 6947
Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile
 1               5                  10                  15      
Ala Asn Ser Gln Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg
            20                  25                  30          
Leu His Arg Phe Leu Cys Phe Gly Ser Glu Gly Gly Thr Tyr Tyr Ile
        35                  40                  45              
Lys Glu Gln Lys Leu Gly Leu Glu Asn Ala Glu Ala Leu Ile Arg Leu
    50                  55                  60                  
Ile Glu Asp Gly Arg Gly Cys Glu Val Ile Gln Glu Ile Lys Ser Phe
65                  70                  75                  80  
Ser Gln Glu Gly Arg Thr Thr Lys Gln Glu Pro Met Leu Phe Ala Leu
                85                  90                  95      
Ala Ile Cys Ser Gln Cys Ser Asp Ile Ser Thr Lys Gln Ala Ala Phe
            100                 105                 110         
Lys Ala Val Ser Glu Val Cys Arg Ile Pro Thr His Leu Phe Thr Phe
        115                 120                 125             
Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser Met Lys Cys Gly Met Trp
    130                 135                 140                 
Gly Arg Ala Leu Arg Lys Ala Ile Ala Asp Trp Tyr Asn Glu Lys Gly
145                 150                 155                 160 
Gly Met Ala Leu Ala Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly
                165                 170                 175     
Trp Ser His Lys Asp Leu Leu Arg Leu Ser His Leu Lys Pro Ser Ser
            180                 185                 190         
Glu Gly Leu Ala Ile Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu
        195                 200                 205             
Val His Glu Leu Tyr Lys Glu Lys Ala Leu Ser Val Glu Thr Glu Lys
    210                 215                 220                 
Leu Leu Lys Tyr Leu Glu Ala Val Glu Lys Val Lys Arg Thr Lys Asp
225                 230                 235                 240 
Glu Leu Glu Val Ile His Leu Ile Glu Glu His Arg Leu Val Arg Glu
                245                 250                 255     
His Leu Leu Thr Asn His Leu Lys Ser Lys Glu Val Trp Lys Ala Leu
            260                 265                 270         
Leu Gln Glu Met Pro Leu Thr Ala Leu Leu Arg Asn Leu Gly Lys Met
        275                 280                 285             
Thr Ala Asn Ser Val Leu Glu Pro Gly Asn Ser Glu Val Ser Leu Val
    290                 295                 300                 
Cys Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His
305                 310                 315                 320 
Pro Phe His Ile Leu Ile Ala Leu Glu Thr Tyr Lys Thr Gly His Gly
                325                 330                 335     
Leu Arg Gly Lys Leu Lys Trp Arg Pro Asp Glu Glu Ile Leu Lys Ala
            340                 345                 350         
Leu Asp Ala Ala Phe Tyr Lys Thr Phe Lys Thr Val Glu Pro Thr Gly
        355                 360                 365             
Lys Arg Phe Leu Leu Ala Val Asp Val Ser Ala Ser Met Asn Gln Arg
    370                 375                 380                 
Val Leu Gly Ser Ile Leu Asn Ala Ser Thr Val Ala Ala Ala Met Cys
385                 390                 395                 400 
Met Val Val Thr Arg Thr Glu Lys Asp Ser Tyr Val Val Ala Phe Ser
                405                 410                 415     
Asp Glu Met Val Pro Cys Pro Val Thr Thr Asp Met Thr Leu Gln Gln
            420                 425                 430         
Val Leu Met Ala Met Ser Gln Ile Pro Ala Gly Gly Thr Asp Cys Ser
        435                 440                 445             
Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro Ala Asp Val Phe
    450                 455                 460                 
Ile Val Phe Thr Asp Asn Glu Thr Phe Ala Gly Gly Val His Pro Ala
465                 470                 475                 480 
Ile Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala Lys Leu
                485                 490                 495     
Ile Val Cys Gly Met Thr Ser Asn Gly Phe Thr Ile Ala Asp Pro Asp
            500                 505                 510         
Asp Arg Gly Met Leu Asp Met Cys Gly Phe Asp Thr Gly Ala Leu Asp
        515                 520                 525             
Val Ile Arg Asn Phe Thr Leu Asp Met Ile
    530                 535             


<210> 6948
<211> 538
<212> PRT
<213> Homo sapiens

<400> 6948
Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile
 1               5                  10                  15      
Ala Asn Ser Gln Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg
            20                  25                  30          
Leu His Arg Phe Leu Cys Phe Gly Ser Glu Gly Gly Thr Tyr Tyr Ile
        35                  40                  45              
Lys Glu Gln Lys Leu Gly Leu Glu Asn Ala Glu Ala Leu Ile Arg Leu
    50                  55                  60                  
Ile Glu Asp Gly Arg Gly Cys Glu Val Ile Gln Glu Ile Lys Ser Phe
65                  70                  75                  80  
Ser Gln Glu Gly Arg Thr Thr Lys Gln Glu Pro Met Leu Phe Ala Leu
                85                  90                  95      
Ala Ile Cys Ser Gln Cys Ser Asp Ile Ser Thr Lys Gln Ala Ala Phe
            100                 105                 110         
Lys Ala Val Ser Glu Val Cys Arg Ile Pro Thr His Leu Phe Thr Phe
        115                 120                 125             
Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser Met Lys Cys Gly Met Trp
    130                 135                 140                 
Gly Arg Ala Leu Arg Lys Ala Ile Ala Asp Trp Tyr Asn Glu Lys Gly
145                 150                 155                 160 
Gly Met Ala Leu Ala Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly
                165                 170                 175     
Trp Ser His Lys Asp Leu Leu Arg Leu Ser His Leu Lys Pro Ser Ser
            180                 185                 190         
Glu Gly Leu Ala Ile Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu
        195                 200                 205             
Val His Glu Leu Tyr Lys Glu Lys Ala Leu Ser Val Glu Thr Glu Lys
    210                 215                 220                 
Leu Leu Lys Tyr Leu Glu Ala Val Glu Lys Val Lys Arg Thr Arg Asp
225                 230                 235                 240 
Glu Leu Glu Val Ile His Leu Ile Glu Glu His Arg Leu Val Arg Glu
                245                 250                 255     
His Leu Leu Thr Asn His Leu Lys Ser Lys Glu Val Trp Lys Ala Leu
            260                 265                 270         
Leu Gln Glu Met Pro Leu Thr Ala Leu Leu Arg Asn Leu Gly Lys Met
        275                 280                 285             
Thr Ala Asn Ser Val Leu Glu Pro Gly Asn Ser Glu Val Ser Leu Val
    290                 295                 300                 
Cys Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His
305                 310                 315                 320 
Pro Phe His Ile Leu Ile Ala Leu Glu Thr Tyr Lys Thr Gly His Gly
                325                 330                 335     
Leu Arg Gly Lys Leu Lys Trp Arg Pro Asp Glu Glu Ile Leu Lys Ala
            340                 345                 350         
Leu Asp Ala Ala Phe Tyr Lys Thr Phe Lys Thr Val Glu Pro Thr Gly
        355                 360                 365             
Lys Arg Phe Leu Leu Ala Val Asp Val Ser Ala Ser Met Asn Gln Arg
    370                 375                 380                 
Val Leu Gly Ser Ile Leu Asn Ala Ser Thr Val Ala Ala Ala Met Cys
385                 390                 395                 400 
Met Val Val Thr Arg Thr Glu Lys Asp Ser Tyr Val Val Ala Phe Ser
                405                 410                 415     
Asp Glu Met Val Pro Cys Pro Val Thr Thr Asp Met Thr Leu Gln Gln
            420                 425                 430         
Val Leu Met Ala Met Ser Gln Ile Pro Ala Gly Gly Thr Asp Cys Ser
        435                 440                 445             
Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro Ala Asp Val Phe
    450                 455                 460                 
Ile Val Phe Thr Asp Asn Glu Thr Phe Ala Gly Gly Val His Pro Ala
465                 470                 475                 480 
Ile Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala Lys Leu
                485                 490                 495     
Ile Val Cys Gly Met Thr Ser Asn Gly Phe Thr Ile Ala Asp Pro Asp
            500                 505                 510         
Asp Arg Gly Met Leu Asp Met Cys Gly Phe Asp Thr Gly Ala Leu Asp
        515                 520                 525             
Val Ile Arg Asn Phe Thr Leu Asp Met Ile
    530                 535             


<210> 6949
<211> 817
<212> PRT
<213> Homo sapiens

<400> 6949
Met Met Asp Gly Pro Arg Ser Asp Val Gly Arg Trp Gly Gly Asn Pro
 1               5                  10                  15      
Leu Gln Pro Pro Thr Thr Pro Ser Pro Glu Pro Glu Pro Glu Pro Asp
            20                  25                  30          
Gly Arg Ser Arg Arg Gly Gly Gly Arg Ser Phe Trp Ala Arg Cys Cys
        35                  40                  45              
Gly Cys Cys Ser Cys Arg Asn Ala Ala Asp Asp Asp Trp Gly Pro Glu
    50                  55                  60                  
Pro Ser Asp Ser Arg Gly Arg Gly Ser Ser Ser Gly Thr Arg Arg Pro
65                  70                  75                  80  
Gly Ser Arg Gly Ser Asp Ser Arg Arg Pro Val Ser Arg Gly Ser Gly
                85                  90                  95      
Val Asn Ala Ala Gly Asp Gly Thr Ile Arg Gly Gly Met Leu Val Val
            100                 105                 110         
Asn Gly Val Asp Leu Leu Ser Ser Arg Ser Asp Gln Asn Arg Arg Glu
        115                 120                 125             
His His Thr Asp Glu Tyr Glu Tyr Asp Glu Leu Ile Val Arg Arg Gly
    130                 135                 140                 
Gln Pro Phe His Met Leu Leu Leu Leu Ser Arg Thr Tyr Glu Ser Ser
145                 150                 155                 160 
Asp Arg Ile Thr Leu Glu Leu Leu Ile Gly Asn Asn Pro Glu Val Gly
                165                 170                 175     
Lys Gly Thr His Val Ile Ile Pro Val Gly Lys Gly Gly Ser Gly Gly
            180                 185                 190         
Trp Lys Ala Gln Val Val Lys Ala Ser Gly Gln Asn Leu Asn Leu Arg
        195                 200                 205             
Val His Thr Ser Pro Asn Ala Ile Ile Gly Lys Phe Gln Phe Thr Val
    210                 215                 220                 
Arg Thr Gln Ser Asp Ala Gly Glu Phe Gln Leu Pro Phe Asp Pro Arg
225                 230                 235                 240 
Asn Glu Ile Tyr Ile Leu Phe Asn Pro Trp Cys Pro Gly Asp Ile Val
                245                 250                 255     
Tyr Val Asp His Glu Asp Trp Arg Gln Glu Tyr Val Leu Asn Glu Ser
            260                 265                 270         
Gly Arg Ile Tyr Tyr Gly Thr Glu Ala Gln Ile Gly Glu Arg Thr Trp
        275                 280                 285             
Asn Tyr Gly Gln Val Asp His Gly Val Leu Asp Ala Cys Leu Tyr Ile
    290                 295                 300                 
Leu Asp Arg Arg Gly Met Pro Tyr Gly Gly Arg Gly Asp Pro Val Asn
305                 310                 315                 320 
Val Ser Arg Val Ile Ser Ala Met Val Asn Ser Leu Asp Asp Asn Gly
                325                 330                 335     
Val Leu Ile Gly Asn Trp Ser Gly Asp Tyr Ser Arg Gly Thr Asn Pro
            340                 345                 350         
Ser Ala Trp Val Gly Ser Val Glu Ile Leu Leu Ser Tyr Leu Arg Thr
        355                 360                 365             
Gly Tyr Ser Val Pro Tyr Gly Gln Cys Trp Val Phe Ala Gly Val Thr
    370                 375                 380                 
Thr Thr Gly Leu Arg Cys Leu Gly Leu Ala Thr Arg Thr Val Thr Asn
385                 390                 395                 400 
Phe Asn Ser Ala His Asp Thr Asp Thr Ser Leu Thr Met Asp Ile Tyr
                405                 410                 415     
Phe Asp Glu Asn Met Lys Pro Leu Glu His Leu Asn His Asp Ser Val
            420                 425                 430         
Trp Asn Phe His Val Trp Asn Asp Cys Trp Met Lys Arg Pro Asp Leu
        435                 440                 445             
Pro Ser Gly Phe Asp Gly Trp Gln Val Val Asp Ala Thr Pro Gln Glu
    450                 455                 460                 
Thr Ser Ser Gly Ile Phe Cys Cys Gly Pro Cys Ser Val Glu Ser Ile
465                 470                 475                 480 
Lys Asn Gly Leu Val Tyr Met Lys Tyr Asp Thr Pro Phe Ile Phe Ala
                485                 490                 495     
Glu Val Asn Ser Asp Lys Val Tyr Trp Gln Arg Gln Asp Asp Gly Ser
            500                 505                 510         
Phe Lys Ile Val Tyr Val Glu Glu Lys Ala Ile Gly Thr Leu Ile Val
        515                 520                 525             
Thr Lys Ala Ile Ser Ser Asn Met Arg Glu Asp Ile Thr Tyr Leu Tyr
    530                 535                 540                 
Lys His Pro Glu Gly Ser Asp Ala Glu Arg Lys Ala Val Glu Thr Ala
545                 550                 555                 560 
Ala Ala His Gly Ser Lys Pro Asn Val Tyr Ala Asn Arg Gly Ser Ala
                565                 570                 575     
Glu Asp Val Ala Met Gln Val Glu Ala Gln Asp Ala Val Met Gly Gln
            580                 585                 590         
Asp Leu Met Val Ser Val Met Leu Ile Asn His Ser Ser Ser Arg Arg
        595                 600                 605             
Thr Val Lys Leu His Leu Tyr Leu Ser Val Thr Phe Tyr Thr Gly Val
    610                 615                 620                 
Ser Gly Thr Ile Phe Lys Glu Thr Lys Lys Glu Val Glu Leu Ala Pro
625                 630                 635                 640 
Gly Ala Trp Asp Arg Val Thr Met Pro Val Ala Tyr Lys Glu Tyr Arg
                645                 650                 655     
Pro His Leu Val Asp Gln Gly Ala Met Leu Leu Asn Val Ser Gly His
            660                 665                 670         
Val Lys Glu Ser Gly Gln Val Leu Ala Lys Gln His Thr Phe Arg Leu
        675                 680                 685             
Arg Thr Pro Asp Leu Ser Leu Thr Val Leu Gly Ala Ala Val Val Gly
    690                 695                 700                 
Gln Glu Cys Glu Val Gln Ile Val Phe Lys Asn Pro Leu Pro Val Thr
705                 710                 715                 720 
Leu Thr Asn Val Val Phe Arg Leu Glu Gly Ser Gly Leu Gln Arg Pro
                725                 730                 735     
Lys Ile Leu Asn Val Gly Asp Ile Gly Gly Asn Glu Thr Val Thr Leu
            740                 745                 750         
Arg Gln Ser Phe Val Pro Val Arg Pro Gly Pro Arg Gln Leu Ile Ala
        755                 760                 765             
Ser Leu Asp Ser Pro Gln Leu Ser Gln Val His Gly Val Ile Gln Val
    770                 775                 780                 
Asp Val Ala Pro Ala Pro Gly Asp Gly Gly Phe Phe Ser Asp Ala Gly
785                 790                 795                 800 
Gly Asp Ser His Leu Gly Glu Thr Ile Pro Met Ala Ser Arg Gly Gly
                805                 810                 815     
Ala
    


<210> 6950
<211> 189
<212> PRT
<213> Homo sapiens

<400> 6950
Met Lys Glu Lys Leu Asn Gly Asp Thr Glu Glu Gly Phe Asn Arg Leu
 1               5                  10                  15      
Ser Asp Glu Phe Ser Lys Ser His Lys Ser Arg Arg Lys Asp Leu Pro
            20                  25                  30          
Asn Gly Asp Ile Asp Glu Tyr Glu Lys Lys Ser Lys Arg Val Ser Ser
        35                  40                  45              
Leu Asp Thr Ser Thr His Lys Ser Ser Asp Asn Lys Leu Glu Glu Thr
    50                  55                  60                  
Leu Thr Arg Glu Gln Lys Glu Gly Ala Phe Ser Asn Phe Pro Ile Ser
65                  70                  75                  80  
Glu Glu Thr Ile Lys Leu Leu Lys Gly Arg Gly Val Thr Tyr Leu Phe
                85                  90                  95      
Pro Ile Gln Val Lys Thr Phe Gly Pro Val Tyr Glu Gly Lys Asp Leu
            100                 105                 110         
Ile Ala Gln Ala Arg Thr Gly Thr Gly Lys Thr Phe Ser Phe Ala Ile
        115                 120                 125             
Pro Leu Ile Glu Arg Leu Gln Arg Asn Gln Glu Thr Ile Lys Lys Ser
    130                 135                 140                 
Arg Ser Pro Lys Val Leu Val Leu Ala Pro Thr Arg Glu Leu Ala Asn
145                 150                 155                 160 
Gln Val Ala Lys Asp Phe Lys Asp Ile Thr Arg Ser Pro Cys Ser Ile
                165                 170                 175     
Asn Ala Ser Ile Ser Ser Ile Thr Ser Tyr Thr Cys Phe
            180                 185                 


<210> 6951
<211> 986
<212> PRT
<213> Homo sapiens

<400> 6951
Met Ser Gln Trp Thr Pro Glu Tyr Lys Glu Leu Tyr Thr Leu Lys Val
 1               5                  10                  15      
Asp Met Lys Ser Glu Ile Pro Ser Asp Ala Pro Lys Thr Gln Glu Ser
            20                  25                  30          
Leu Lys Gly Ile Leu Leu His Pro Glu Pro Ile Gly Ala Ala Lys Ser
        35                  40                  45              
Phe Pro Ala Gly Val Glu Met Ile Asn Ser Lys Val Gly Asn Glu Phe
    50                  55                  60                  
Ser His Leu Cys Asp Asp Ser Gln Lys Gln Glu Lys Glu Met Asn Gly
65                  70                  75                  80  
Asn Gln Gln Glu Gln Glu Lys Ser Leu Val Val Arg Lys Lys Arg Lys
                85                  90                  95      
Ser Gln Gln Ala Gly Pro Ser Tyr Val Gln Asn Cys Val Lys Glu Asn
            100                 105                 110         
Gln Gly Ile Leu Gly Leu Arg Gln His Leu Gly Thr Pro Ser Asp Glu
        115                 120                 125             
Asp Asn Asp Ser Ser Phe Ser Asp Cys Leu Ser Ser Pro Ser Ser Ser
    130                 135                 140                 
Leu His Phe Gly Asp Ser Asp Thr Val Thr Ser Asp Glu Asp Lys Glu
145                 150                 155                 160 
Val Ser Val Arg His Ser Gln Thr Ile Leu Asn Ala Lys Ser Arg Ser
                165                 170                 175     
His Ser Ala Arg Ser His Lys Trp Pro Arg Thr Glu Thr Glu Ser Val
            180                 185                 190         
Ser Gly Leu Leu Met Lys Arg Pro Cys Leu His Gly Ser Ser Leu Arg
        195                 200                 205             
Arg Leu Pro Cys Arg Lys Arg Phe Val Lys Asn Asn Ser Ser Gln Arg
    210                 215                 220                 
Thr Gln Lys Gln Lys Glu Arg Ile Leu Met Gln Arg Lys Lys Arg Glu
225                 230                 235                 240 
Val Leu Ala Arg Arg Lys Tyr Ala Leu Leu Pro Ser Ser Ser Ser Ser
                245                 250                 255     
Ser Glu Asn Asp Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Thr Glu
            260                 265                 270         
Gly Glu Glu Asp Leu Phe Val Ser Ala Ser Glu Asn His Gln Asn Asn
        275                 280                 285             
Pro Ala Val Pro Ser Gly Ser Ile Asp Glu Asp Val Val Val Ile Glu
    290                 295                 300                 
Ala Ser Ser Thr Pro Gln Val Thr Ala Asn Glu Glu Ile Asn Val Thr
305                 310                 315                 320 
Ser Thr Asp Ser Glu Val Glu Ile Val Thr Val Gly Glu Ser Tyr Arg
                325                 330                 335     
Ser Arg Ser Thr Leu Gly His Ser Arg Ser His Trp Ser Gln Gly Ser
            340                 345                 350         
Ser Ser His Ala Ser Arg Pro Gln Glu Pro Arg Asn Arg Ser Arg Ile
        355                 360                 365             
Ser Thr Val Ile Gln Pro Leu Arg Gln Asn Ala Ala Glu Val Val Asp
    370                 375                 380                 
Leu Thr Val Asp Glu Asp Glu Pro Thr Val Val Pro Thr Thr Ser Ala
385                 390                 395                 400 
Arg Met Glu Ser Gln Ala Thr Ser Ala Ser Ile Asn Asn Ser Asn Pro
                405                 410                 415     
Ser Thr Ser Glu Gln Ala Ser Asp Thr Ala Ser Ala Val Thr Ser Ser
            420                 425                 430         
Gln Pro Ser Thr Val Ser Glu Thr Ser Ala Thr Leu Thr Ser Asn Ser
        435                 440                 445             
Thr Thr Gly Thr Ser Ile Gly Asp Asp Ser Arg Arg Thr Thr Ser Ser
    450                 455                 460                 
Ala Val Thr Glu Thr Gly Pro Pro Glu Met Pro Arg Leu Pro Ser Cys
465                 470                 475                 480 
Cys Pro Gln His Ser Pro Cys Gly Gly Ser Ser Gln Asn His His Ala
                485                 490                 495     
Leu Gly His Pro His Thr Ser Cys Phe Gln Gln His Gly His His Phe
            500                 505                 510         
Gln His His His His His His His Thr Pro His Pro Ala Val Pro Val
        515                 520                 525             
Ser Pro Ser Phe Ser Asp Pro Ala Cys Pro Val Glu Arg Pro Pro Gln
    530                 535                 540                 
Val Gln Ala Pro Cys Gly Ala Asn Ser Ser Ser Gly Thr Ser Tyr His
545                 550                 555                 560 
Glu Gln Gln Ala Leu Pro Val Asp Leu Ser Asn Ser Gly Ile Arg Ser
                565                 570                 575     
His Gly Ser Gly Ser Phe His Gly Ala Ser Ala Phe Asp Pro Cys Cys
            580                 585                 590         
Pro Val Ser Ser Ser Arg Ala Ala Ile Phe Gly His Gln Ala Ala Ala
        595                 600                 605             
Ala Ala Pro Ser Gln Pro Leu Ser Ser Ile Asp Gly Tyr Gly Ser Ser
    610                 615                 620                 
Met Val Ala Gln Pro Gln Pro Gln Pro Pro Pro Gln Pro Ser Leu Ser
625                 630                 635                 640 
Ser Cys Arg His Tyr Met Pro Pro Pro Tyr Ala Ser Leu Thr Arg Pro
                645                 650                 655     
Leu His His Gln Ala Ser Ala Cys Pro His Ser His Gly Asn Pro Pro
            660                 665                 670         
Pro Gln Thr Gln Pro Pro Pro Gln Val Asp Tyr Val Ile Pro His Pro
        675                 680                 685             
Val His Ala Phe His Ser Gln Ile Ser Ser His Ala Thr Ser His Pro
    690                 695                 700                 
Val Ala Pro Pro Pro Pro Thr His Leu Ala Ser Thr Ala Ala Pro Ile
705                 710                 715                 720 
Pro Gln His Leu Pro Pro Thr His Gln Pro Ile Ser His His Ile Pro
                725                 730                 735     
Ala Thr Ala Pro Pro Ala Gln Arg Leu His Pro His Glu Val Met Gln
            740                 745                 750         
Arg Met Glu Val Gln Arg Arg Arg Met Met Gln His Pro Thr Arg Ala
        755                 760                 765             
His Glu Arg Pro Pro Pro His Pro His Arg Met His Pro Asn Tyr Gly
    770                 775                 780                 
His Gly His His Ile His Val Pro Gln Thr Met Ser Ser His Pro Arg
785                 790                 795                 800 
Gln Ala Pro Glu Arg Ser Ala Trp Gly Leu Gly Ile Glu Ala Gly Val
                805                 810                 815     
Thr Ala Ala Thr Tyr Thr Pro Gly Ala Leu His Pro His Leu Ala His
            820                 825                 830         
Tyr His Ala Pro Pro Arg Leu His His Leu Gln Leu Gly Ala Leu Pro
        835                 840                 845             
Leu Met Val Pro Asp Met Ala Gly Tyr Pro His Ile Arg Tyr Ile Ser
    850                 855                 860                 
Ser Gly Leu Asp Gly Thr Ser Phe Arg Gly Pro Phe Arg Gly Asn Phe
865                 870                 875                 880 
Glu Glu Leu Ile His Leu Glu Glu Arg Leu Gly Asn Val Asn Arg Gly
                885                 890                 895     
Ala Ser Gln Gly Thr Ile Glu Arg Cys Thr Tyr Pro His Lys Tyr Lys
            900                 905                 910         
Lys Arg Lys Leu His Cys Lys Gln Asp Gly Gly Glu Gly Thr Glu Glu
        915                 920                 925             
Asp Thr Glu Glu Lys Cys Thr Ile Cys Leu Ser Ile Leu Glu Glu Gly
    930                 935                 940                 
Glu Asp Val Arg Arg Leu Pro Cys Met His Leu Phe His Gln Val Cys
945                 950                 955                 960 
Val Asp Gln Trp Leu Ile Thr Asn Lys Lys Cys Pro Ile Cys Arg Val
                965                 970                 975     
Asp Ile Glu Ala Gln Leu Pro Ser Glu Ser
            980                 985     


<210> 6952
<211> 365
<212> PRT
<213> Homo sapiens

<400> 6952
Ser Ala Ala Arg Trp Glu Phe Gly Phe Gly Trp Leu Gln Pro Ala Ser
 1               5                  10                  15      
Arg Val Lys Thr Pro Thr Pro Gly Ala Ala Gly Ser Thr His Gly Asp
            20                  25                  30          
Pro Arg Gly Ala Ala Ala Ala Pro Gly Asn Trp Ser Ser Arg Gln Arg
        35                  40                  45              
Pro Ala His Pro Arg Thr Pro Gly Pro Ala Ala Ser Val Phe Ser Arg
    50                  55                  60                  
Ser Val Gln Arg Leu Thr Met Arg Asn Thr Ser Lys Glu Leu Gln Gly
65                  70                  75                  80  
Ala Thr His Arg Tyr Ala Pro Cys Asp Trp Tyr Tyr His Val Pro Val
                85                  90                  95      
Lys Arg Ser Glu Lys Ala Val Asp Ala Pro Pro Ala Ser Gln Ile Pro
            100                 105                 110         
Gly Leu Ser Asn Leu Gly Asp Ser His Ser Glu Asn Leu Pro Gly Thr
        115                 120                 125             
Arg Arg Tyr Trp Ile Lys Glu Thr Asp Ser Glu Tyr Val Lys Leu Ala
    130                 135                 140                 
Lys Gln Gly Gly Arg Pro Asp Leu Leu Lys His Phe Ala Pro Gly Thr
145                 150                 155                 160 
Arg Lys Gly Ser Pro Val Ala Tyr Ser Leu Pro Asp Trp Tyr Ile His
                165                 170                 175     
His Ser Lys Pro Pro Thr Ala Ser Gln Gln Glu Val Arg Ala Val Ser
            180                 185                 190         
Met Leu Asp Tyr Met Val His Glu Glu Phe Asn Pro Asp Gln Ala Asn
        195                 200                 205             
Gly Ser Tyr Ala Ser Arg Arg Gly Pro Phe Asp Phe Asp Thr Lys Thr
    210                 215                 220                 
Val Trp Gln Arg Glu Ala Glu Glu Leu Glu Lys Glu Lys Lys Lys Leu
225                 230                 235                 240 
Arg Leu Pro Ala Ile Asp Ser Lys Tyr Leu Ser Lys Ala Gly Thr Pro
                245                 250                 255     
Leu Gly Pro Lys Asn Pro Ala Gly Ser Arg Leu Ser Phe Pro His Val
            260                 265                 270         
Pro Gly Gln Lys Asn Ser Ser Pro Thr Asn Phe Ser Lys Leu Ile Ser
        275                 280                 285             
Asn Gly Tyr Lys Asp Glu Trp Leu Gln Gln Gln Gln Arg Ala Asp Ser
    290                 295                 300                 
Asp Lys Arg Thr Pro Lys Thr Ser Arg Ala Ser Val Leu Ser Gln Ser
305                 310                 315                 320 
Pro Arg Asp Leu Glu Gly Pro Gln Asp Ala Ala Arg Leu Gln Asp Ala
                325                 330                 335     
Glu Ala Ser Glu Gly Pro Glu Asp Thr Pro Glu Ser Ser Gln Ser Pro
            340                 345                 350         
Glu Glu Ser Val Ser Ala Ser Thr Pro Ala Glu Leu Lys
        355                 360                 365 


<210> 6953
<211> 813
<212> PRT
<213> Homo sapiens

<400> 6953
Asp Pro Glu Thr Pro Ser Asp Ala Ala Ala Met Glu Ser Gly Pro Arg
 1               5                  10                  15      
Ala Glu Leu Gly Ala Gly Ala Pro Pro Ala Val Val Ala Arg Thr Pro
            20                  25                  30          
Pro Glu Pro Arg Pro Ser Pro Glu Gly Asp Pro Ser Pro Pro Pro Pro
        35                  40                  45              
Pro Met Ser Ala Leu Val Pro Asp Thr Pro Pro Asp Thr Pro Pro Ala
    50                  55                  60                  
Met Lys Asn Ala Thr Ser Ser Lys Gln Leu Pro Leu Glu Pro Glu Ser
65                  70                  75                  80  
Pro Ser Gly Gln Val Gly Pro Arg Pro Ala Pro Pro Gln Glu Glu Ser
                85                  90                  95      
Pro Ser Ser Glu Ala Lys Ser Arg Gly Pro Thr Pro Pro Ala Met Gly
            100                 105                 110         
Pro Arg Asp Ala Arg Pro Pro Arg Arg Ser Ser Gln Pro Ser Pro Thr
        115                 120                 125             
Ala Val Pro Ala Ser Asp Ser Pro Pro Thr Lys Gln Glu Val Lys Lys
    130                 135                 140                 
Ala Gly Glu Arg His Lys Leu Ala Lys Glu Arg Arg Glu Glu Arg Ala
145                 150                 155                 160 
Lys Tyr Leu Ala Ala Lys Lys Ala Val Trp Leu Glu Lys Glu Glu Lys
                165                 170                 175     
Ala Lys Ala Leu Arg Glu Lys Gln Leu Gln Glu Arg Arg Arg Arg Leu
            180                 185                 190         
Glu Glu Gln Arg Leu Lys Ala Glu Gln Arg Arg Ala Ala Leu Glu Glu
        195                 200                 205             
Arg Gln Arg Gln Lys Leu Glu Lys Asn Lys Glu Arg Tyr Glu Ala Ala
    210                 215                 220                 
Ile Gln Arg Ser Val Lys Lys Thr Trp Ala Glu Ile Arg Gln Gln Arg
225                 230                 235                 240 
Trp Ser Trp Ala Gly Ala Leu His His Ser Ser Pro Gly His Lys Thr
                245                 250                 255     
Asn Arg Ser Leu Gln Leu Ser Ala Trp Glu Ser Ser Ile Val Asp Arg
            260                 265                 270         
Leu Met Thr Pro Thr Leu Ser Phe Leu Ala Arg Ser Arg Ser Ala Val
        275                 280                 285             
Thr Leu Pro Arg Asn Gly Arg Asp Gln Gly Arg Gly Cys Asp Pro Gly
    290                 295                 300                 
Arg Gly Pro Thr Trp Gly Arg Ala Gly Ala Ser Leu Ala Arg Gly Pro
305                 310                 315                 320 
Gln Pro Asp Arg Thr His Pro Ser Ala Ala Val Pro Val Cys Pro Arg
                325                 330                 335     
Ser Ala Ser Ala Ser Pro Leu Thr Pro Cys Ser Val Thr Arg Ser Val
            340                 345                 350         
His Arg Cys Ala Pro Ala Gly Glu Arg Gly Glu Arg Arg Lys Pro Asn
        355                 360                 365             
Ala Gly Gly Ser Pro Ala Pro Val Arg Arg Arg Pro Glu Ala Ser Pro
    370                 375                 380                 
Val Gln Lys Lys Glu Lys Lys Asp Lys Glu Arg Glu Asn Glu Lys Glu
385                 390                 395                 400 
Lys Ser Ala Leu Ala Arg Glu Arg Ser Leu Lys Lys Arg Gln Ser Leu
                405                 410                 415     
Pro Ala Ser Pro Arg Ala Arg Leu Ser Ala Ser Thr Ala Ser Glu Leu
            420                 425                 430         
Ser Pro Lys Ser Lys Ala Arg Pro Ser Ser Pro Ser Thr Ser Trp His
        435                 440                 445             
Arg Pro Ala Ser Pro Cys Pro Ser Pro Gly Pro Gly His Thr Leu Pro
    450                 455                 460                 
Pro Lys Pro Pro Ser Pro Arg Gly Thr Thr Ala Ser Pro Lys Gly Arg
465                 470                 475                 480 
Val Arg Arg Lys Glu Glu Ala Lys Glu Ser Pro Ser Ala Ala Gly Pro
                485                 490                 495     
Glu Asp Lys Ser Gln Ser Lys Arg Arg Ala Ser Asn Glu Lys Glu Ser
            500                 505                 510         
Ala Ala Pro Ala Ser Pro Ala Pro Ser Pro Ala Pro Ser Pro Thr Pro
        515                 520                 525             
Ala Pro Pro Gln Lys Glu Gln Pro Pro Ala Glu Thr Pro Thr Asp Ala
    530                 535                 540                 
Ala Val Leu Thr Ser Pro Pro Ala Pro Ala Pro Pro Val Thr Pro Ser
545                 550                 555                 560 
Lys Pro Met Ala Gly Thr Thr Asp Arg Glu Glu Ala Thr Arg Leu Leu
                565                 570                 575     
Ala Glu Lys Arg Arg Gln Ala Arg Glu Gln Arg Glu Arg Glu Glu Gln
            580                 585                 590         
Glu Arg Arg Leu Gln Ala Glu Arg Asp Lys Arg Met Arg Glu Glu Gln
        595                 600                 605             
Leu Ala Arg Glu Ala Glu Ala Arg Ala Glu Arg Glu Ala Glu Ala Arg
    610                 615                 620                 
Arg Arg Glu Glu Gln Glu Ala Arg Glu Lys Ala Gln Ala Glu Gln Glu
625                 630                 635                 640 
Glu Gln Glu Arg Leu Gln Lys Gln Lys Glu Glu Ala Glu Ala Arg Ser
                645                 650                 655     
Arg Glu Glu Ala Glu Arg Gln Arg Leu Glu Arg Glu Lys His Phe Gln
            660                 665                 670         
Gln Gln Glu Gln Glu Arg Gln Glu Arg Arg Lys Arg Leu Glu Glu Ile
        675                 680                 685             
Met Lys Arg Thr Arg Lys Ser Glu Val Ser Glu Thr Lys Lys Gln Asp
    690                 695                 700                 
Ser Lys Glu Ala Asn Ala Asn Gly Ser Ser Pro Glu Pro Val Lys Ala
705                 710                 715                 720 
Val Glu Ala Arg Ser Pro Gly Leu Gln Lys Glu Ala Val Gln Lys Glu
                725                 730                 735     
Glu Pro Ile Pro Gln Glu Pro Gln Trp Ser Leu Pro Ser Lys Glu Leu
            740                 745                 750         
Pro Ala Ser Leu Val Asn Gly Leu Gln Pro Leu Pro Ala His Gln Glu
        755                 760                 765             
Asn Gly Phe Ser Thr Asn Gly Pro Ser Gly Asp Lys Ser Leu Ser Arg
    770                 775                 780                 
Thr Pro Glu Thr Leu Leu Pro Phe Ala Glu Ala Glu Ala Phe Leu Lys
785                 790                 795                 800 
Lys Ala Val Val Gln Ser Pro Gln Val Thr Glu Val Leu
                805                 810             


<210> 6954
<211> 1581
<212> PRT
<213> Homo sapiens

<400> 6954
Met Lys Ala Gln Gly Glu Thr Glu Glu Ser Glu Lys Leu Ser Lys Met
 1               5                  10                  15      
Ser Ser Leu Leu Glu Arg Leu His Ala Lys Phe Asn Gln Asn Arg Pro
            20                  25                  30          
Trp Ser Glu Thr Ile Lys Leu Val Arg Gln Val Met Glu Lys Arg Val
        35                  40                  45              
Val Met Ser Ser Gly Gly His Gln His Leu Val Ser Cys Leu Glu Thr
    50                  55                  60                  
Leu Gln Lys Ala Leu Lys Val Thr Ser Leu Pro Ala Met Thr Asp Arg
65                  70                  75                  80  
Leu Glu Ser Ile Ala Arg Gln Asn Gly Leu Gly Ser His Leu Ser Ala
                85                  90                  95      
Ser Gly Thr Glu Cys Tyr Ile Thr Ser Asp Met Phe Tyr Val Glu Val
            100                 105                 110         
Gln Leu Asp Pro Ala Gly Gln Leu Cys Asp Val Lys Val Ala His His
        115                 120                 125             
Gly Glu Asn Pro Val Ser Cys Pro Glu Leu Val Gln Gln Leu Arg Glu
    130                 135                 140                 
Lys Asn Phe Asp Glu Phe Ser Lys His Leu Lys Gly Leu Val Asn Leu
145                 150                 155                 160 
Tyr Asn Leu Pro Gly Asp Asn Lys Leu Lys Thr Lys Met Tyr Leu Ala
                165                 170                 175     
Leu Gln Ser Leu Glu Gln Asp Leu Ser Lys Met Ala Ile Met Tyr Trp
            180                 185                 190         
Lys Ala Thr Asn Ala Gly Pro Leu Asp Lys Ile Leu His Gly Ser Val
        195                 200                 205             
Gly Tyr Leu Thr Pro Arg Ser Gly Gly His Leu Met Asn Leu Lys Tyr
    210                 215                 220                 
Tyr Val Ser Pro Ser Asp Leu Leu Asp Asp Lys Thr Ala Ser Pro Ile
225                 230                 235                 240 
Ile Leu His Glu Asn Asn Val Ser Arg Ser Leu Gly Met Asn Ala Ser
                245                 250                 255     
Val Thr Ile Glu Gly Thr Ser Ala Val Tyr Lys Leu Pro Ile Ala Pro
            260                 265                 270         
Leu Ile Met Gly Ser His Pro Val Asp Asn Lys Trp Thr Pro Ser Phe
        275                 280                 285             
Ser Ser Ile Thr Ser Ala Asn Ser Val Asp Leu Pro Ala Cys Phe Phe
    290                 295                 300                 
Leu Lys Phe Pro Gln Pro Ile Pro Val Ser Arg Ala Phe Val Gln Lys
305                 310                 315                 320 
Leu Gln Asn Cys Thr Gly Ile Pro Leu Phe Glu Thr Gln Pro Thr Tyr
                325                 330                 335     
Ala Pro Leu Tyr Glu Leu Ile Thr Gln Phe Glu Leu Ser Lys Asp Pro
            340                 345                 350         
Asp Pro Ile Pro Leu Asn His Asn Met Arg Phe Tyr Ala Ala Leu Pro
        355                 360                 365             
Gly Gln Gln His Cys Tyr Phe Leu Asn Lys Asp Ala Pro Leu Pro Asp
    370                 375                 380                 
Gly Arg Ser Leu Gln Gly Thr Leu Val Ser Lys Ile Thr Phe Gln His
385                 390                 395                 400 
Pro Gly Arg Val Pro Leu Ile Leu Asn Leu Ile Arg His Gln Val Ala
                405                 410                 415     
Tyr Asn Thr Leu Ile Gly Ser Cys Val Lys Arg Thr Ile Leu Lys Glu
            420                 425                 430         
Asp Ser Pro Gly Leu Leu Gln Phe Glu Val Cys Pro Leu Ser Glu Ser
        435                 440                 445             
Arg Phe Ser Val Ser Phe Gln His Pro Val Asn Asp Ser Leu Val Cys
    450                 455                 460                 
Val Val Met Asp Val Gln Asp Ser Thr His Val Ser Cys Lys Leu Tyr
465                 470                 475                 480 
Lys Gly Leu Ser Asp Ala Leu Ile Cys Thr Asp Asp Phe Ile Ala Lys
                485                 490                 495     
Val Val Gln Arg Cys Met Ser Ile Pro Val Thr Met Arg Ala Ile Arg
            500                 505                 510         
Arg Lys Ala Glu Thr Ile Gln Ala Asp Thr Pro Ala Leu Ser Leu Ile
        515                 520                 525             
Ala Glu Thr Val Glu Asp Met Val Lys Lys Asn Leu Pro Pro Ala Ser
    530                 535                 540                 
Ser Pro Gly Tyr Gly Met Thr Thr Gly Asn Asn Pro Met Ser Gly Thr
545                 550                 555                 560 
Thr Thr Ser Thr Asn Thr Phe Pro Gly Gly Pro Ile Ala Thr Leu Phe
                565                 570                 575     
Asn Met Ser Met Ser Ile Lys Asp Arg His Glu Ser Val Gly His Gly
            580                 585                 590         
Glu Asp Phe Ser Lys Val Ser Gln Asn Pro Ile Leu Thr Ser Leu Leu
        595                 600                 605             
Gln Ile Thr Gly Asn Gly Gly Ser Thr Ile Gly Ser Ser Pro Thr Pro
    610                 615                 620                 
Pro His His Thr Pro Pro Pro Val Ser Ser Met Ala Gly Asn Thr Lys
625                 630                 635                 640 
Asn His Pro Met Leu Met Asn Leu Leu Lys Asp Asn Pro Ala Gln Asp
                645                 650                 655     
Phe Ser Thr Leu Tyr Gly Ser Ser Pro Leu Glu Arg Gln Asn Ser Ser
            660                 665                 670         
Ser Gly Ser Pro Arg Met Glu Ile Cys Ser Gly Ser Asn Lys Thr Lys
        675                 680                 685             
Lys Lys Lys Ser Ser Arg Leu Pro Pro Glu Lys Pro Lys His Gln Thr
    690                 695                 700                 
Glu Asp Asp Phe Gln Arg Glu Leu Phe Ser Met Asp Val Asp Ser Gln
705                 710                 715                 720 
Asn Pro Ile Phe Asp Val Asn Met Thr Ala Asp Thr Leu Asp Thr Pro
                725                 730                 735     
His Ile Thr Pro Ala Pro Ser Gln Cys Ser Thr Pro Pro Thr Thr Tyr
            740                 745                 750         
Pro Gln Pro Val Pro His Pro Gln Pro Ser Ile Gln Arg Met Val Arg
        755                 760                 765             
Leu Ser Ser Ser Asp Ser Ile Gly Pro Asp Val Thr Asp Ile Leu Ser
    770                 775                 780                 
Asp Ile Ala Glu Glu Ala Ser Lys Leu Pro Ser Thr Ser Asp Asp Cys
785                 790                 795                 800 
Pro Ala Ile Gly Thr Pro Leu Arg Asp Ser Ser Ser Ser Gly His Ser
                805                 810                 815     
Gln Ser Thr Leu Phe Asp Ser Asp Val Phe Gln Thr Asn Asn Asn Glu
            820                 825                 830         
Asn Pro Tyr Thr Asp Pro Ala Asp Leu Ile Ala Asp Ala Ala Gly Ser
        835                 840                 845             
Pro Ser Ser Asp Ser Pro Thr Asn His Phe Phe His Asp Gly Val Asp
    850                 855                 860                 
Phe Asn Pro Asp Leu Leu Asn Ser Gln Ser Gln Ser Gly Phe Gly Glu
865                 870                 875                 880 
Glu Tyr Phe Asp Glu Ser Ser Gln Ser Gly Asp Asn Asp Asp Phe Lys
                885                 890                 895     
Gly Phe Ala Ser Gln Ala Leu Asn Thr Leu Gly Val Pro Met Leu Gly
            900                 905                 910         
Gly Asp Asn Gly Glu Thr Lys Phe Lys Gly Asn Asn Gln Ala Asp Thr
        915                 920                 925             
Val Asp Phe Ser Ile Ile Ser Val Ala Gly Lys Ala Leu Ala Pro Ala
    930                 935                 940                 
Asp Leu Met Glu His His Ser Gly Ser Gln Gly Pro Leu Leu Thr Thr
945                 950                 955                 960 
Gly Asp Leu Gly Lys Glu Lys Thr Gln Lys Arg Val Lys Glu Gly Asn
                965                 970                 975     
Gly Thr Ser Asn Ser Thr Leu Ser Gly Pro Gly Leu Asp Ser Lys Pro
            980                 985                 990         
Gly Lys Arg Ser Arg Thr Pro Ser Asn Asp Gly Lys Ser Lys Asp Lys
        995                 1000                1005            
Pro Pro Lys Arg Lys Lys Ala Asp Thr Glu Gly Lys Ser Pro Ser His
    1010                1015                1020                
Ser Ser Ser Asn Arg Pro Phe Thr Pro Pro Thr Ser Thr Gly Gly Ser
1025                1030                1035                1040
Lys Ser Pro Gly Ser Ala Gly Arg Ser Gln Thr Pro Pro Gly Val Ala
                1045                1050                1055    
Thr Pro Pro Ile Pro Lys Ile Thr Ile Gln Ile Pro Lys Gly Thr Val
            1060                1065                1070        
Met Val Gly Lys Pro Ser Ser His Ser Gln Tyr Thr Ser Ser Gly Ser
        1075                1080                1085            
Val Ser Ser Ser Gly Ser Lys Ser His His Ser His Ser Ser Ser Ser
    1090                1095                1100                
Ser Ser Ser Ala Ser Thr Ser Gly Lys Met Lys Ser Ser Lys Ser Glu
1105                1110                1115                1120
Gly Ser Ser Ser Ser Lys Leu Ser Ser Ser Met Tyr Ser Ser Gln Gly
                1125                1130                1135    
Ser Ser Gly Ser Ser Gln Ser Lys Asn Ser Ser Gln Ser Gly Gly Lys
            1140                1145                1150        
Pro Gly Ser Ser Pro Ile Thr Lys His Gly Leu Ser Ser Gly Ser Ser
        1155                1160                1165            
Ser Thr Lys Met Lys Pro Gln Gly Lys Pro Ser Ser Leu Met Asn Pro
    1170                1175                1180                
Ser Leu Ser Lys Pro Asn Ile Ser Pro Ser His Ser Arg Pro Pro Gly
1185                1190                1195                1200
Gly Ser Asp Lys Leu Ala Ser Pro Met Lys Pro Val Pro Gly Thr Pro
                1205                1210                1215    
Pro Ser Ser Lys Ala Lys Ser Pro Ile Ser Ser Gly Ser Gly Gly Ser
            1220                1225                1230        
His Met Ser Gly Thr Ser Ser Ser Ser Gly Met Lys Ser Ser Ser Gly
        1235                1240                1245            
Leu Gly Ser Ser Gly Ser Leu Ser Gln Lys Thr Pro Pro Ser Ser Asn
    1250                1255                1260                
Ser Cys Thr Ala Ser Ser Ser Ser Phe Ser Ser Ser Gly Ser Ser Met
1265                1270                1275                1280
Ser Ser Ser Gln Asn Gln His Gly Ser Ser Lys Gly Lys Ser Pro Ser
                1285                1290                1295    
Arg Asn Lys Lys Pro Ser Leu Thr Ala Val Ile Asp Lys Leu Lys His
            1300                1305                1310        
Gly Val Val Thr Ser Gly Pro Gly Gly Glu Asp Pro Leu Asp Gly Gln
        1315                1320                1325            
Met Gly Val Ser Thr Asn Ser Ser Ser His Pro Met Ser Ser Lys His
    1330                1335                1340                
Asn Met Ser Gly Gly Glu Phe Gln Gly Lys Arg Glu Lys Ser Asp Lys
1345                1350                1355                1360
Asp Lys Ser Lys Val Ser Thr Ser Gly Ser Ser Val Asp Ser Ser Lys
                1365                1370                1375    
Lys Thr Ser Glu Ser Lys Asn Val Gly Ser Thr Gly Val Ala Lys Ile
            1380                1385                1390        
Ile Ile Ser Lys His Asp Gly Gly Ser Pro Ser Ile Lys Ala Lys Val
        1395                1400                1405            
Thr Leu Gln Lys Pro Gly Glu Ser Ser Gly Glu Gly Leu Arg Pro Gln
    1410                1415                1420                
Met Ala Ser Ser Lys Asn Tyr Gly Ser Pro Leu Ile Ser Gly Ser Thr
1425                1430                1435                1440
Pro Lys His Glu Arg Gly Ser Pro Ser His Ser Lys Ser Pro Ala Tyr
                1445                1450                1455    
Thr Pro Gln Asn Leu Asp Ser Glu Ser Glu Ser Gly Ser Ser Ile Ala
            1460                1465                1470        
Glu Lys Ser Tyr Gln Asn Ser Pro Ser Ser Asp Asp Gly Ile Arg Pro
        1475                1480                1485            
Leu Pro Glu Tyr Ser Thr Glu Lys His Lys Lys His Lys Lys Glu Lys
    1490                1495                1500                
Lys Lys Val Lys Asp Lys Asp Arg Asp Arg Asp Arg Asp Lys Asp Arg
1505                1510                1515                1520
Asp Lys Lys Lys Ser His Ser Ile Lys Pro Glu Ser Trp Ser Lys Ser
                1525                1530                1535    
Pro Ile Ser Ser Asp Gln Ser Leu Ser Met Thr Ser Asn Thr Ile Leu
            1540                1545                1550        
Ser Ala Asp Arg Pro Ser Arg Leu Ser Pro Asp Phe Met Ile Gly Glu
        1555                1560                1565            
Glu Asp Asp Asp Leu Met Asp Val Ala Leu Ile Gly Asn
    1570                1575                1580    


<210> 6955
<211> 111
<212> PRT
<213> Homo sapiens

<400> 6955
Met Val Arg Thr Lys Ala Asp Ser Val Pro Gly Thr Tyr Arg Lys Val
 1               5                  10                  15      
Val Ala Ala Arg Ala Pro Arg Lys Val Leu Gly Ser Ser Thr Ser Ala
            20                  25                  30          
Thr Asn Ser Thr Ser Val Ser Ser Arg Lys Ala Glu Asn Lys Tyr Ala
        35                  40                  45              
Gly Gly Asn Pro Val Cys Val Arg Pro Thr Pro Lys Trp Gln Lys Gly
    50                  55                  60                  
Ile Gly Glu Phe Phe Arg Leu Ser Pro Lys Asp Ser Glu Lys Glu Asn
65                  70                  75                  80  
Gln Ile Pro Glu Glu Ala Gly Ser Ser Gly Leu Gly Lys Ala Lys Arg
                85                  90                  95      
Lys Ala Cys Pro Leu Gln Pro Asp His Thr Asn Asp Glu Lys Glu
            100                 105                 110     


<210> 6956
<211> 2098
<212> PRT
<213> Homo sapiens

<400> 6956
Met Ala Thr Asp Asp Lys Thr Ser Pro Thr Leu Asp Ser Ala Asn Asp
 1               5                  10                  15      
Leu Pro Arg Ser Pro Thr Ser Pro Ser His Leu Thr His Phe Lys Pro
            20                  25                  30          
Leu Thr Pro Asp Gln Asp Glu Pro Pro Phe Lys Ser Ala Tyr Ser Ser
        35                  40                  45              
Phe Val Asn Leu Phe Arg Phe Asn Lys Glu Arg Ala Glu Gly Gly Gln
    50                  55                  60                  
Gly Glu Gln Gln Pro Leu Ser Gly Ser Trp Thr Ser Pro Gln Leu Pro
65                  70                  75                  80  
Ser Arg Thr Gln Ser Val Arg Ser Pro Thr Pro Tyr Lys Lys Gln Leu
                85                  90                  95      
Asn Glu Glu Leu Gln Arg Arg Ser Ser Ala Leu Asp Thr Arg Arg Lys
            100                 105                 110         
Ala Glu Pro Thr Phe Gly Gly His Asp Pro Arg Thr Ala Val Gln Leu
        115                 120                 125             
Arg Ser Leu Ser Thr Val Leu Lys Arg Leu Lys Glu Ile Met Glu Gly
    130                 135                 140                 
Lys Ser Gln Asp Ser Asp Leu Lys Gln Tyr Trp Met Pro Asp Ser Gln
145                 150                 155                 160 
Cys Lys Glu Cys Tyr Asp Cys Ser Glu Lys Phe Thr Thr Phe Arg Arg
                165                 170                 175     
Arg His His Cys Arg Leu Cys Gly Gln Ile Phe Cys Ser Arg Cys Cys
            180                 185                 190         
Asn Gln Glu Ile Pro Gly Lys Phe Met Gly Tyr Thr Gly Asp Leu Arg
        195                 200                 205             
Ala Cys Thr Tyr Cys Arg Lys Ile Ala Leu Ser Tyr Ala His Ser Thr
    210                 215                 220                 
Asp Ser Asn Ser Ile Gly Glu Asp Leu Asn Ala Leu Ser Asp Ser Ala
225                 230                 235                 240 
Cys Ser Val Ser Val Leu Asp Pro Ser Glu Pro Arg Thr Pro Val Gly
                245                 250                 255     
Ser Arg Lys Ala Ser Arg Asn Ile Phe Leu Glu Asp Asp Leu Ala Trp
            260                 265                 270         
Gln Ser Leu Ile His Pro Asp Ser Ser Asn Thr Pro Leu Ser Thr Arg
        275                 280                 285             
Leu Val Ser Val Gln Glu Asp Ala Gly Lys Ser Pro Ala Arg Asn Arg
    290                 295                 300                 
Ser Ala Ser Ile Thr Asn Leu Ser Leu Asp Arg Ser Gly Ser Pro Met
305                 310                 315                 320 
Val Pro Ser Tyr Glu Thr Ser Val Ser Pro Gln Ala Asn Arg Thr Tyr
                325                 330                 335     
Val Arg Thr Glu Thr Thr Glu Asp Glu Arg Lys Ile Leu Leu Asp Ser
            340                 345                 350         
Val Gln Leu Lys Asp Leu Trp Lys Lys Ile Cys His His Ser Ser Gly
        355                 360                 365             
Met Glu Phe Gln Asp His Arg Tyr Trp Leu Arg Thr His Pro Asn Cys
    370                 375                 380                 
Ile Val Gly Lys Glu Leu Val Asn Trp Leu Ile Arg Asn Gly His Ile
385                 390                 395                 400 
Ala Thr Arg Ala Gln Ala Ile Ala Ile Gly Gln Ala Met Val Asp Gly
                405                 410                 415     
Arg Trp Leu Asp Cys Val Ser His His Asp Gln Leu Phe Arg Asp Glu
            420                 425                 430         
Tyr Ala Leu Tyr Arg Pro Leu Gln Ser Thr Glu Phe Ser Glu Thr Pro
        435                 440                 445             
Ser Pro Asp Ser Asp Ser Val Asn Ser Val Glu Gly His Ser Glu Pro
    450                 455                 460                 
Ser Trp Phe Lys Asp Ile Lys Phe Asp Asp Ser Asp Thr Glu Gln Ile
465                 470                 475                 480 
Ala Glu Glu Gly Asp Asp Asn Leu Ala Asn Ser Ala Ser Pro Ser Lys
                485                 490                 495     
Arg Thr Ser Val Ser Ser Phe Gln Ser Thr Val Asp Ser Asp Ser Ala
            500                 505                 510         
Ala Ser Ile Ser Leu Asn Val Glu Leu Asp Asn Val Asn Phe His Ile
        515                 520                 525             
Lys Lys Pro Ser Lys Tyr Pro His Val Pro Pro His Pro Ala Asp Gln
    530                 535                 540                 
Lys Glu Tyr Leu Ile Ser Asp Thr Gly Gly Gln Gln Leu Ser Ile Ser
545                 550                 555                 560 
Asp Ala Phe Ile Lys Glu Ser Leu Phe Asn Arg Arg Val Glu Glu Lys
                565                 570                 575     
Ser Lys Glu Leu Pro Phe Thr Pro Leu Gly Trp His His Asn Asn Leu
            580                 585                 590         
Glu Leu Leu Arg Glu Glu Asn Gly Glu Lys Gln Ala Met Glu Arg Leu
        595                 600                 605             
Leu Ser Ala Asn His Asn His Met Met Ala Leu Leu Gln Gln Leu Leu
    610                 615                 620                 
His Ser Asp Ser Leu Ser Ser Ser Trp Arg Asp Ile Ile Val Ser Leu
625                 630                 635                 640 
Val Cys Gln Val Val Gln Thr Val Arg Pro Asp Val Lys Asn Gln Asp
                645                 650                 655     
Asp Asp Met Asp Ile Arg Gln Phe Val His Ile Lys Lys Ile Pro Gly
            660                 665                 670         
Gly Lys Lys Phe Asp Ser Val Val Val Asn Gly Phe Val Cys Thr Lys
        675                 680                 685             
Asn Ile Ala His Lys Lys Met Asn Ser Cys Ile Lys Asn Pro Lys Ile
    690                 695                 700                 
Leu Leu Leu Lys Cys Ser Ile Glu Tyr Leu Tyr Arg Glu Glu Thr Lys
705                 710                 715                 720 
Phe Thr Cys Ile Asp Pro Ile Val Leu Gln Glu Arg Glu Phe Leu Lys
                725                 730                 735     
Asn Tyr Val Gln Arg Ile Val Asp Val Arg Pro Thr Leu Val Leu Val
            740                 745                 750         
Glu Lys Thr Val Ser Arg Ile Ala Gln Asp Met Leu Leu Glu His Gly
        755                 760                 765             
Ile Thr Leu Val Ile Asn Val Lys Ser Gln Val Leu Glu Arg Ile Ser
    770                 775                 780                 
Arg Met Thr Gln Gly Asp Leu Val Met Ser Met Asp Gln Leu Leu Thr
785                 790                 795                 800 
Lys Pro His Leu Gly Thr Cys His Lys Phe Tyr Met Gln Ile Phe Gln
                805                 810                 815     
Leu Pro Asn Glu Gln Thr Lys Thr Leu Met Phe Phe Glu Gly Cys Pro
            820                 825                 830         
Gln His Leu Gly Cys Thr Ile Lys Leu Arg Gly Gly Ser Asp Tyr Glu
        835                 840                 845             
Leu Ala Arg Val Lys Glu Ile Leu Ile Phe Met Ile Cys Val Ala Tyr
    850                 855                 860                 
His Ser Gln Leu Glu Ile Ser Phe Leu Met Asp Glu Phe Ala Met Pro
865                 870                 875                 880 
Pro Thr Leu Met Gln Asn Pro Ser Phe His Ser Leu Ile Glu Gly Arg
                885                 890                 895     
Gly His Glu Gly Ala Val Gln Glu Gln Tyr Gly Gly Gly Ser Ile Pro
            900                 905                 910         
Trp Asp Pro Asp Ile Pro Pro Glu Ser Leu Pro Cys Asp Asp Ser Ser
        915                 920                 925             
Leu Leu Glu Ser Arg Ile Val Phe Glu Lys Gly Glu Gln Glu Asn Lys
    930                 935                 940                 
Asn Leu Pro Gln Ala Val Ala Ser Val Lys His Gln Glu His Ser Thr
945                 950                 955                 960 
Thr Ala Cys Pro Ala Gly Leu Pro Cys Ala Phe Phe Ala Pro Val Pro
                965                 970                 975     
Glu Ser Leu Leu Pro Leu Pro Val Asp Asp Gln Gln Asp Ala Leu Gly
            980                 985                 990         
Ser Glu Leu Pro Glu Ser Leu Gln Gln Thr Val Val Leu Gln Asp Pro
        995                 1000                1005            
Lys Ser Gln Ile Arg Ala Phe Arg Asp Pro Leu Gln Asp Asp Thr Gly
    1010                1015                1020                
Leu Tyr Val Thr Glu Glu Val Thr Ser Ser Glu Asp Lys Arg Lys Thr
1025                1030                1035                1040
Tyr Ser Leu Ala Phe Lys Gln Glu Leu Lys Asp Val Ile Leu Cys Ile
                1045                1050                1055    
Ser Pro Val Ile Thr Phe Arg Glu Pro Phe Leu Leu Thr Glu Lys Gly
            1060                1065                1070        
Met Arg Cys Ser Thr Arg Asp Tyr Phe Ala Glu Gln Val Tyr Trp Ser
        1075                1080                1085            
Pro Leu Leu Asn Lys Glu Phe Lys Glu Met Glu Asn Arg Arg Lys Lys
    1090                1095                1100                
Gln Leu Leu Arg Asp Leu Ser Gly Leu Gln Gly Met Asn Gly Ser Ile
1105                1110                1115                1120
Gln Ala Lys Ser Ile Gln Val Leu Pro Ser His Glu Leu Val Ser Thr
                1125                1130                1135    
Arg Ile Ala Glu His Leu Gly Asp Ser Gln Ser Leu Gly Arg Met Leu
            1140                1145                1150        
Ala Asp Tyr Arg Ala Arg Gly Gly Arg Ile Gln Pro Lys Asn Ser Asp
        1155                1160                1165            
Pro Phe Ala His Ser Lys Asp Ala Ser Ser Thr Ser Ser Gly Lys Ser
    1170                1175                1180                
Gly Ser Lys Asn Glu Gly Asp Glu Glu Arg Gly Leu Ile Leu Ser Asp
1185                1190                1195                1200
Ala Val Trp Ser Thr Lys Val Asp Cys Leu Asn Pro Ile Asn His Gln
                1205                1210                1215    
Arg Leu Cys Val Leu Phe Ser Ser Ser Ser Ala Gln Ser Ser Asn Ala
            1220                1225                1230        
Pro Ser Ala Cys Val Ser Pro Trp Ile Val Thr Met Glu Phe Tyr Gly
        1235                1240                1245            
Lys Asn Asp Leu Thr Leu Gly Ile Phe Leu Glu Arg Tyr Cys Phe Arg
    1250                1255                1260                
Pro Ser Tyr Gln Cys Pro Ser Met Phe Cys Asp Thr Pro Met Val His
1265                1270                1275                1280
His Ile Arg Arg Phe Val His Gly Gln Gly Cys Val Gln Ile Ile Leu
                1285                1290                1295    
Lys Glu Leu Asp Ser Pro Val Pro Gly Tyr Gln His Thr Ile Leu Thr
            1300                1305                1310        
Tyr Ser Trp Cys Arg Ile Cys Lys Gln Val Thr Pro Val Val Ala Leu
        1315                1320                1325            
Ser Asn Glu Ser Trp Ser Met Ser Phe Ala Lys Tyr Leu Glu Leu Arg
    1330                1335                1340                
Phe Tyr Gly His Gln Tyr Thr Arg Arg Ala Asn Ala Glu Pro Cys Gly
1345                1350                1355                1360
His Ser Ile His His Asp Tyr His Gln Tyr Phe Ser Tyr Asn Gln Met
                1365                1370                1375    
Val Ala Ser Phe Ser Tyr Ser Pro Ile Arg Leu Leu Glu Val Cys Val
            1380                1385                1390        
Pro Leu Pro Lys Ile Phe Ile Lys Arg Gln Ala Pro Leu Lys Val Ser
        1395                1400                1405            
Leu Leu Gln Asp Leu Lys Asp Phe Phe Gln Lys Val Ser Gln Val Tyr
    1410                1415                1420                
Val Ala Ile Asp Glu Arg Leu Ala Ser Leu Lys Thr Asp Thr Phe Ser
1425                1430                1435                1440
Lys Thr Arg Glu Glu Lys Met Glu Asp Ile Phe Ala Gln Lys Glu Met
                1445                1450                1455    
Glu Glu Gly Glu Phe Lys Asn Trp Ile Glu Lys Met Gln Ala Arg Leu
            1460                1465                1470        
Met Ser Ser Ser Val Asp Thr Pro Gln Gln Leu Gln Ser Val Phe Glu
        1475                1480                1485            
Ser Leu Ile Ala Lys Lys Gln Ser Leu Cys Glu Val Leu Gln Ala Trp
    1490                1495                1500                
Asn Asn Arg Leu Gln Asp Leu Phe Gln Gln Glu Lys Gly Arg Lys Arg
1505                1510                1515                1520
Pro Ser Val Pro Pro Ser Pro Gly Arg Leu Arg Gln Gly Glu Glu Ser
                1525                1530                1535    
Lys Ile Ser Ala Met Asp Ala Ser Pro Arg Asn Ile Ser Pro Gly Leu
            1540                1545                1550        
Gln Asn Gly Glu Lys Glu Asp Arg Phe Leu Thr Thr Leu Ser Ser Gln
        1555                1560                1565            
Ser Ser Thr Ser Ser Thr His Leu Gln Leu Pro Thr Pro Pro Glu Val
    1570                1575                1580                
Met Ser Glu Gln Ser Val Gly Gly Pro Pro Glu Leu Asp Thr Ala Ser
1585                1590                1595                1600
Ser Ser Glu Asp Val Phe Asp Gly His Leu Leu Gly Ser Thr Asp Ser
                1605                1610                1615    
Gln Val Lys Glu Lys Ser Thr Met Lys Ala Ile Phe Ala Asn Leu Leu
            1620                1625                1630        
Pro Gly Asn Ser Tyr Asn Pro Ile Pro Phe Pro Phe Asp Pro Asp Lys
        1635                1640                1645            
His Tyr Leu Met Tyr Glu His Glu Arg Val Pro Ile Ala Val Cys Glu
    1650                1655                1660                
Lys Glu Pro Ser Ser Ile Ile Ala Phe Ala Leu Ser Cys Lys Glu Tyr
1665                1670                1675                1680
Arg Asn Ala Leu Glu Glu Leu Ser Lys Ala Thr Gln Trp Asn Ser Ala
                1685                1690                1695    
Glu Glu Gly Leu Pro Thr Asn Ser Thr Ser Asp Ser Arg Pro Lys Ser
            1700                1705                1710        
Ser Ser Pro Ile Arg Leu Pro Glu Met Ser Gly Gly Gln Thr Asn Arg
        1715                1720                1725            
Thr Thr Glu Thr Glu Pro Gln Pro Thr Lys Lys Ala Ser Gly Met Leu
    1730                1735                1740                
Ser Phe Phe Arg Gly Thr Ala Gly Lys Ser Pro Asp Leu Ser Ser Gln
1745                1750                1755                1760
Lys Arg Glu Thr Leu Arg Gly Ala Asp Ser Ala Tyr Tyr Gln Val Gly
                1765                1770                1775    
Gln Thr Gly Lys Glu Gly Thr Glu Asn Gln Gly Val Glu Pro Gln Asp
            1780                1785                1790        
Glu Val Asp Gly Gly Asp Thr Gln Lys Lys Gln Leu Ile Asn Pro His
        1795                1800                1805            
Val Glu Leu Gln Phe Ser Asp Ala Asn Ala Lys Phe Tyr Cys Arg Leu
    1810                1815                1820                
Tyr Tyr Ala Gly Glu Phe His Lys Met Arg Glu Val Ile Leu Asp Ser
1825                1830                1835                1840
Ser Glu Glu Asp Phe Ile Arg Ser Leu Ser His Ser Ser Pro Trp Gln
                1845                1850                1855    
Ala Arg Gly Gly Lys Ser Gly Ala Ala Phe Tyr Ala Thr Glu Asp Asp
            1860                1865                1870        
Arg Phe Ile Leu Lys Gln Met Pro Arg Leu Glu Val Gln Ser Phe Leu
        1875                1880                1885            
Asp Phe Ala Pro His Tyr Phe Asn Tyr Ile Thr Asn Ala Val Gln Gln
    1890                1895                1900                
Lys Arg Pro Thr Ala Leu Ala Lys Ile Leu Gly Val Tyr Arg Ile Gly
1905                1910                1915                1920
Tyr Lys Asn Ser Gln Asn Asn Thr Glu Lys Lys Leu Asp Leu Leu Val
                1925                1930                1935    
Met Glu Asn Leu Phe Tyr Gly Arg Lys Met Ala Gln Val Phe Asp Leu
            1940                1945                1950        
Lys Gly Ser Leu Arg Asn Arg Asn Val Lys Thr Asp Thr Gly Lys Glu
        1955                1960                1965            
Ser Cys Asp Val Val Leu Leu Asp Glu Asn Leu Leu Lys Met Val Arg
    1970                1975                1980                
Asp Asn Pro Leu Tyr Ile Arg Ser His Ser Lys Ala Val Leu Arg Thr
1985                1990                1995                2000
Ser Ile His Ser Asp Ser His Phe Leu Ser Ser His Leu Ile Ile Asp
                2005                2010                2015    
Tyr Ser Leu Leu Val Gly Arg Asp Asp Thr Ser Asn Glu Leu Val Val
            2020                2025                2030        
Gly Ile Ile Asp Tyr Ile Arg Thr Phe Thr Trp Asp Lys Lys Leu Glu
        2035                2040                2045            
Met Val Val Lys Ser Thr Gly Ile Leu Gly Gly Gln Gly Lys Met Pro
    2050                2055                2060                
Thr Val Val Ser Pro Glu Leu Tyr Arg Thr Arg Phe Cys Glu Ala Met
2065                2070                2075                2080
Asp Lys Tyr Phe Leu Met Val Pro Asp His Trp Thr Gly Leu Gly Leu
                2085                2090                2095    
Asn Cys
        


<210> 6957
<211> 1613
<212> PRT
<213> Homo sapiens

<400> 6957
Met Ser Lys Ile Asp Ile Phe Met Glu Ile Leu Lys Thr Glu Ile Gly
 1               5                  10                  15      
Lys Met Met Glu Asn Ile Trp Val Ser Met Lys Gly Gly Lys Ser Arg
            20                  25                  30          
Tyr Asp Thr Cys Val Arg Ile Asn Tyr Arg Trp Trp Ser Leu Gly Gly
        35                  40                  45              
Tyr Tyr Glu Gly Phe Glu Tyr Lys Leu Thr Asp Val Glu Tyr Leu Ile
    50                  55                  60                  
Ser Asp Thr Gly Gly Gln Gln Leu Ser Ile Ser Asp Ala Phe Ile Lys
65                  70                  75                  80  
Glu Ser Leu Phe Asn Arg Arg Val Glu Glu Lys Ser Lys Glu Leu Pro
                85                  90                  95      
Phe Thr Pro Leu Gly Trp His His Asn Asn Leu Glu Leu Leu Arg Glu
            100                 105                 110         
Glu Asn Gly Glu Lys Gln Ala Met Glu Arg Leu Leu Ser Ala Asn His
        115                 120                 125             
Asn His Met Met Ala Leu Leu Gln Gln Leu Leu His Ser Asp Ser Leu
    130                 135                 140                 
Ser Ser Ser Trp Arg Asp Ile Ile Val Ser Leu Val Cys Gln Val Val
145                 150                 155                 160 
Gln Thr Val Arg Pro Asp Val Lys Asn Gln Asp Asp Asp Met Asp Ile
                165                 170                 175     
Arg Gln Phe Val His Ile Lys Lys Ile Pro Gly Gly Lys Lys Phe Asp
            180                 185                 190         
Ser Val Val Val Asn Gly Phe Val Cys Thr Lys Asn Ile Ala His Lys
        195                 200                 205             
Lys Met Ser Ser Cys Ile Lys Asn Pro Lys Ile Leu Leu Leu Lys Cys
    210                 215                 220                 
Ser Ile Glu Tyr Leu Tyr Arg Glu Glu Thr Lys Phe Thr Cys Ile Asp
225                 230                 235                 240 
Pro Ile Val Leu Gln Glu Arg Glu Phe Leu Lys Asn Tyr Val Gln Arg
                245                 250                 255     
Ile Val Asp Val Arg Pro Thr Leu Val Leu Val Glu Lys Thr Val Ser
            260                 265                 270         
Arg Ile Ala Gln Asp Met Leu Leu Glu His Gly Ile Thr Leu Val Ile
        275                 280                 285             
Asn Val Lys Ser Gln Val Leu Glu Arg Ile Ser Arg Met Thr Gln Gly
    290                 295                 300                 
Asp Leu Val Met Ser Met Asp Gln Leu Leu Thr Lys Pro His Leu Gly
305                 310                 315                 320 
Thr Cys His Lys Phe Tyr Met Gln Ile Phe Gln Leu Pro Asn Glu Gln
                325                 330                 335     
Thr Lys Thr Leu Met Phe Phe Glu Gly Cys Pro Gln His Leu Gly Cys
            340                 345                 350         
Thr Ile Lys Leu Arg Gly Gly Ser Asp Tyr Glu Leu Ala Arg Val Lys
        355                 360                 365             
Glu Ile Leu Ile Phe Met Ile Cys Val Ala Tyr His Ser Gln Leu Glu
    370                 375                 380                 
Ile Ser Phe Leu Met Asp Glu Phe Ala Met Pro Pro Thr Leu Met Gln
385                 390                 395                 400 
Asn Pro Ser Phe His Ser Leu Ile Glu Gly Arg Gly His Glu Gly Ala
                405                 410                 415     
Val Gln Glu Gln Tyr Gly Gly Gly Ser Ile Pro Trp Asp Pro Asp Ile
            420                 425                 430         
Pro Pro Glu Ser Leu Pro Cys Asp Asp Ser Ser Leu Leu Glu Leu Arg
        435                 440                 445             
Ile Val Phe Glu Lys Gly Glu Gln Glu Asn Lys Asn Leu Pro Gln Ala
    450                 455                 460                 
Val Ala Ser Val Lys His Gln Glu His Ser Thr Thr Ala Cys Pro Ala
465                 470                 475                 480 
Gly Leu Pro Cys Ala Phe Phe Ala Pro Val Pro Glu Ser Leu Leu Pro
                485                 490                 495     
Leu Pro Val Asp Asp Gln Gln Asp Ala Leu Gly Ser Glu Gln Pro Glu
            500                 505                 510         
Thr Leu Gln Gln Thr Val Val Leu Gln Asp Pro Lys Ser Gln Ile Arg
        515                 520                 525             
Ala Phe Arg Asp Pro Leu Gln Asp Asp Thr Gly Leu Tyr Val Thr Glu
    530                 535                 540                 
Glu Val Thr Ser Ser Glu Asp Lys Arg Lys Thr Tyr Ser Leu Ala Phe
545                 550                 555                 560 
Lys Gln Glu Leu Lys Asp Val Ile Leu Cys Ile Ser Pro Val Ile Thr
                565                 570                 575     
Phe Arg Glu Pro Phe Leu Leu Thr Glu Lys Gly Met Arg Cys Ser Thr
            580                 585                 590         
Arg Asp Tyr Phe Ala Glu Gln Val Tyr Trp Ser Pro Leu Leu Asn Lys
        595                 600                 605             
Glu Phe Lys Glu Met Glu Asn Arg Arg Lys Lys Gln Leu Leu Arg Asp
    610                 615                 620                 
Leu Ser Gly Leu Gln Gly Met Asn Gly Ser Ile Gln Ala Lys Ser Ile
625                 630                 635                 640 
Gln Val Leu Pro Ser His Glu Leu Val Ser Thr Arg Ile Ala Glu His
                645                 650                 655     
Leu Gly Asp Ser Gln Ser Leu Gly Arg Met Leu Ala Asp Tyr Arg Ala
            660                 665                 670         
Arg Gly Gly Arg Ile Gln Pro Lys Asn Ser Asp Pro Phe Ala His Ser
        675                 680                 685             
Lys Asp Ala Ser Ser Thr Ser Ser Gly Gln Ser Gly Ser Lys Asn Glu
    690                 695                 700                 
Gly Asp Glu Glu Arg Gly Leu Ile Leu Ser Asp Ala Val Trp Ser Thr
705                 710                 715                 720 
Lys Val Asp Cys Leu Asn Pro Ile Asn His Gln Arg Leu Cys Val Leu
                725                 730                 735     
Phe Ser Ser Ser Ser Ala Gln Ser Ser Asn Ala Pro Ser Ala Cys Val
            740                 745                 750         
Ser Pro Trp Ile Val Thr Met Glu Phe Tyr Gly Lys Asn Asp Leu Thr
        755                 760                 765             
Leu Gly Ile Phe Leu Glu Arg Tyr Cys Phe Arg Pro Ser Tyr Gln Cys
    770                 775                 780                 
Pro Ser Met Phe Cys Asp Thr Pro Met Val His His Ile Arg Arg Phe
785                 790                 795                 800 
Val His Gly Gln Gly Cys Val Gln Ile Ile Leu Lys Glu Leu Asp Ser
                805                 810                 815     
Pro Val Pro Gly Tyr Gln His Thr Ile Leu Thr Tyr Ser Trp Cys Arg
            820                 825                 830         
Ile Cys Lys Gln Val Thr Pro Val Val Ala Leu Ser Asn Glu Ser Trp
        835                 840                 845             
Ser Met Ser Phe Ala Lys Tyr Leu Glu Leu Arg Phe Tyr Gly His Gln
    850                 855                 860                 
Tyr Thr Arg Arg Ala Asn Ala Glu Pro Cys Gly His Ser Ile His His
865                 870                 875                 880 
Asp Tyr His Gln Tyr Phe Ser Tyr Asn Gln Met Val Ala Ser Phe Ser
                885                 890                 895     
Tyr Ser Pro Ile Arg Leu Leu Glu Val Cys Val Pro Leu Pro Lys Ile
            900                 905                 910         
Phe Ile Lys Arg Gln Ala Pro Leu Lys Val Ser Leu Leu Gln Asp Leu
        915                 920                 925             
Lys Asp Phe Phe Gln Lys Val Ser Gln Val Tyr Val Ala Ile Asp Glu
    930                 935                 940                 
Arg Leu Ala Ser Leu Lys Thr Asp Thr Phe Ser Lys Thr Arg Glu Glu
945                 950                 955                 960 
Lys Met Glu Asp Ile Phe Ala Gln Lys Glu Met Glu Glu Gly Glu Phe
                965                 970                 975     
Lys Asn Trp Ile Glu Lys Met Gln Ala Arg Leu Met Ser Ser Ser Val
            980                 985                 990         
Asp Thr Pro Gln Gln Leu Gln Ser Val Phe Glu Ser Leu Ile Ala Lys
        995                 1000                1005            
Lys Gln Ser Leu Cys Glu Val Leu Gln Ala Trp Asn Asn Arg Leu Gln
    1010                1015                1020                
Asp Leu Phe Gln Gln Glu Lys Gly Arg Lys Arg Pro Ser Val Pro Pro
1025                1030                1035                1040
Ser Pro Gly Arg Leu Arg Gln Gly Glu Glu Ser Lys Ile Ser Ala Met
                1045                1050                1055    
Asp Ala Ser Pro Arg Asn Ile Ser Pro Gly Leu Gln Asn Gly Glu Lys
            1060                1065                1070        
Glu Asp Arg Phe Leu Thr Thr Leu Ser Ser Gln Ser Ser Thr Ser Ser
        1075                1080                1085            
Thr His Leu Gln Leu Pro Thr Pro Pro Glu Val Met Ser Glu Gln Ser
    1090                1095                1100                
Val Gly Gly Pro Pro Glu Leu Asp Thr Ala Ser Ser Ser Glu Asp Val
1105                1110                1115                1120
Phe Asp Gly His Leu Leu Gly Ser Thr Asp Ser Gln Val Lys Glu Lys
                1125                1130                1135    
Ser Thr Met Lys Ala Ile Phe Ala Asn Leu Leu Pro Gly Asn Ser Tyr
            1140                1145                1150        
Asn Pro Ile Pro Phe Pro Phe Asp Pro Asp Lys His Tyr Leu Met Tyr
        1155                1160                1165            
Glu His Glu Arg Val Pro Ile Ala Val Cys Glu Lys Glu Pro Ser Ser
    1170                1175                1180                
Ile Ile Ala Phe Ala Leu Ser Cys Lys Glu Tyr Arg Asn Ala Leu Glu
1185                1190                1195                1200
Glu Leu Ser Lys Ala Thr Gln Trp Asn Ser Ala Glu Glu Gly Leu Pro
                1205                1210                1215    
Thr Asn Ser Thr Ser Asp Ser Arg Pro Lys Ser Ser Ser Pro Ile Arg
            1220                1225                1230        
Leu Pro Glu Met Ser Gly Gly Gln Thr Asn Arg Thr Thr Glu Thr Glu
        1235                1240                1245            
Pro Gln Pro Thr Lys Lys Ala Ser Gly Met Leu Ser Phe Phe Arg Gly
    1250                1255                1260                
Thr Ala Gly Lys Ser Pro Asp Leu Ser Ser Gln Lys Arg Glu Thr Leu
1265                1270                1275                1280
Arg Gly Ala Asp Ser Ala Tyr Tyr Gln Val Gly Gln Thr Gly Lys Glu
                1285                1290                1295    
Gly Thr Glu Asn Gln Gly Val Glu Pro Gln Asp Glu Val Asp Gly Gly
            1300                1305                1310        
Asp Thr Gln Lys Lys Gln Leu Ile Asn Pro His Val Glu Leu Gln Phe
        1315                1320                1325            
Ser Asp Ala Asn Ala Lys Phe Tyr Cys Arg Leu Tyr Tyr Ala Gly Glu
    1330                1335                1340                
Phe His Lys Met Arg Glu Val Ile Leu Asp Ser Ser Glu Glu Asp Phe
1345                1350                1355                1360
Ile Arg Ser Leu Ser His Ser Ser Pro Trp Gln Ala Arg Gly Gly Lys
                1365                1370                1375    
Ser Gly Ala Ala Phe Tyr Ala Thr Glu Asp Asp Arg Phe Ile Leu Lys
            1380                1385                1390        
Gln Met Pro Arg Leu Glu Val Gln Ser Phe Leu Asp Phe Ala Pro His
        1395                1400                1405            
Tyr Phe Asn Tyr Ile Thr Asn Ala Val Gln Gln Lys Arg Pro Thr Ala
    1410                1415                1420                
Leu Ala Lys Ile Leu Gly Val Tyr Arg Ile Gly Tyr Lys Asn Ser Gln
1425                1430                1435                1440
Asn Asn Thr Glu Lys Lys Leu Asp Leu Leu Val Met Glu Asn Leu Phe
                1445                1450                1455    
Tyr Gly Arg Lys Met Ala Gln Val Phe Asp Leu Lys Gly Ser Leu Arg
            1460                1465                1470        
Asn Arg Asn Val Lys Thr Asp Thr Gly Lys Glu Ser Cys Asp Val Val
        1475                1480                1485            
Leu Leu Asp Glu Asn Leu Leu Lys Met Val Arg Asp Asn Pro Leu Tyr
    1490                1495                1500                
Ile Arg Ser His Ser Lys Ala Val Leu Arg Thr Ser Ile His Ser Asp
1505                1510                1515                1520
Ser His Phe Leu Ser Ser His Leu Ile Ile Asp Tyr Ser Leu Leu Val
                1525                1530                1535    
Gly Arg Asp Asp Thr Ser Asn Glu Leu Val Val Gly Ile Ile Asp Tyr
            1540                1545                1550        
Ile Arg Thr Phe Thr Trp Asp Lys Lys Leu Glu Met Val Val Lys Ser
        1555                1560                1565            
Thr Gly Ile Leu Gly Gly Gln Gly Lys Met Pro Thr Val Val Ser Pro
    1570                1575                1580                
Glu Leu Tyr Arg Thr Arg Phe Cys Glu Ala Met Asp Lys Tyr Phe Leu
1585                1590                1595                1600
Met Val Pro Asp His Trp Thr Gly Leu Gly Leu Asn Cys
                1605                1610            


<210> 6958
<211> 419
<212> PRT
<213> Homo sapiens

<400> 6958
Met Pro Ala Glu Asn Ser Pro Ala Pro Ala Tyr Lys Val Ser Ser His
 1               5                  10                  15      
Gly Gly Asp Ser Gly Leu Asp Gly Leu Gly Gly Pro Gly Val Gln Leu
            20                  25                  30          
Gly Ser Pro Asp Lys Lys Lys Arg Lys Ala Asn Thr Gln Gly Pro Ser
        35                  40                  45              
Phe Pro Pro Leu Ser Glu Tyr Ala Pro Pro Pro Asn Pro Asn Ser Asp
    50                  55                  60                  
His Leu Val Ala Ala Asn Pro Phe Asp Asp Asn Tyr Asn Thr Ile Ser
65                  70                  75                  80  
Tyr Lys Pro Leu Pro Ser Ser Asn Pro Tyr Leu Gly Pro Gly Tyr Pro
                85                  90                  95      
Gly Phe Gly Gly Tyr Ser Thr Phe Arg Met Pro Pro His Val Pro Pro
            100                 105                 110         
Arg Met Ser Ser Pro Tyr Cys Gly Pro Tyr Ser Leu Arg Asn Gln Pro
        115                 120                 125             
His Pro Phe Pro Gln Asn Pro Leu Gly Met Gly Phe Asn Arg Pro His
    130                 135                 140                 
Ala Phe Asn Phe Gly Pro His Asp Asn Ser Ser Phe Gly Asn Pro Ser
145                 150                 155                 160 
Tyr Asn Asn Ala Leu Ser Gln Asn Val Asn Met Pro Asn Gln His Phe
                165                 170                 175     
Arg Gln Asn Pro Ala Glu Asn Phe Ser Gln Ile Pro Pro Gln Asn Ala
            180                 185                 190         
Ser Gln Val Ser Asn Pro Asp Leu Ala Ser Asn Phe Val Pro Gly Asn
        195                 200                 205             
Asn Ser Asn Phe Thr Ser Pro Leu Glu Ser Asn His Ser Phe Ile Pro
    210                 215                 220                 
Pro Pro Asn Thr Phe Gly Gln Ala Lys Ala Pro Pro Pro Lys Gln Asp
225                 230                 235                 240 
Phe Thr Gln Gly Ala Thr Lys Asn Thr Asn Gln Asn Ser Ser Ala His
                245                 250                 255     
Pro Pro His Leu Asn Met Asp Asp Thr Val Asn Gln Ser Asn Ile Glu
            260                 265                 270         
Leu Lys Asn Val Asn Arg Asn Asn Ala Val Asn Gln Glu Asn Ser Arg
        275                 280                 285             
Ser Ser Ser Thr Glu Ala Thr Asn Asn Asn Pro Ala Asn Gly Thr Gln
    290                 295                 300                 
Asn Lys Pro Arg Gln Pro Arg Gly Ala Ala Asp Ala Cys Thr Thr Glu
305                 310                 315                 320 
Lys Ser Asn Lys Ser Ser Leu His Pro Asn Arg His Gly His Ser Ser
                325                 330                 335     
Ser Asp Pro Val Tyr Pro Cys Gly Ile Cys Thr Asn Glu Val Asn Asp
            340                 345                 350         
Asp Gln Asp Ala Ile Leu Cys Glu Ala Ser Cys Gln Lys Trp Phe His
        355                 360                 365             
Arg Ile Cys Thr Gly Met Thr Glu Thr Ala Tyr Gly Leu Leu Thr Ala
    370                 375                 380                 
Glu Ala Ser Ala Val Trp Gly Cys Asp Thr Cys Met Ala Asp Lys Asp
385                 390                 395                 400 
Val Gln Leu Met Arg Thr Arg Glu Thr Phe Gly Pro Ser Ala Val Gly
                405                 410                 415     
Ser Asp Ala
            


<210> 6959
<211> 207
<212> PRT
<213> Homo sapiens

<400> 6959
Met Ala Lys Thr Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Thr Cys Leu Leu Phe Arg Phe Ser Glu Asp Ala
            20                  25                  30          
Phe Asn Thr Thr Phe Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg
        35                  40                  45              
Thr Ile Glu Leu Asp Gly Lys Lys Ile Lys Leu Gln Ile Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly
65                  70                  75                  80  
Ala Met Gly Ile Met Leu Val Tyr Asp Ile Thr Asn Glu Lys Ser Phe
                85                  90                  95      
Asp Asn Ile Lys Asn Trp Ile Arg Asn Ile Glu Glu His Ala Ser Ser
            100                 105                 110         
Asp Val Glu Arg Met Ile Leu Gly Asn Lys Cys Asp Met Asn Asp Lys
        115                 120                 125             
Arg Gln Val Ser Lys Glu Arg Gly Glu Lys Leu Ala Ile Asp Tyr Gly
    130                 135                 140                 
Ile Lys Phe Leu Glu Thr Ser Ala Lys Ser Ser Ala Asn Val Glu Glu
145                 150                 155                 160 
Ala Phe Phe Thr Leu Ala Arg Asp Ile Met Thr Lys Leu Asn Arg Lys
                165                 170                 175     
Met Asn Asp Ser Asn Ser Ala Gly Ala Gly Gly Pro Val Lys Ile Thr
            180                 185                 190         
Glu Asn Arg Ser Lys Lys Thr Ser Phe Phe Arg Cys Ser Leu Leu
        195                 200                 205         


<210> 6960
<211> 145
<212> PRT
<213> Homo sapiens

<400> 6960
Met Ala Val Ser Thr Gly Val Lys Val Pro Arg Asn Phe Arg Leu Leu
 1               5                  10                  15      
Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr Val Ser
            20                  25                  30          
Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp Thr Gly
        35                  40                  45              
Met Ile Ile Gly Pro Pro Arg Thr Asn Tyr Glu Asn Arg Ile Tyr Ser
    50                  55                  60                  
Leu Lys Val Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro Ser Val
65                  70                  75                  80  
Arg Phe Val Thr Lys Ile Asn Met Asn Gly Ile Asn Asn Ser Ser Gly
                85                  90                  95      
Met Val Asp Ala Arg Ser Ile Pro Val Leu Ala Lys Trp Gln Asn Ser
            100                 105                 110         
Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met Met Ser
        115                 120                 125             
Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Thr Tyr Asn
    130                 135                 140                 
Asn
145 


<210> 6961
<211> 319
<212> PRT
<213> Homo sapiens

<400> 6961
Met Ala Ser Asp Asp Phe Asp Ile Val Ile Glu Ala Met Leu Glu Ala
 1               5                  10                  15      
Pro Tyr Lys Lys Glu Glu Asp Glu Gln Gln Arg Lys Glu Val Lys Lys
            20                  25                  30          
Asp Tyr Pro Ser Asn Thr Thr Ser Ser Thr Ser Asn Ser Gly Asn Glu
        35                  40                  45              
Thr Ser Gly Ser Ser Thr Ile Gly Glu Thr Ser Lys Lys Lys Arg Ser
    50                  55                  60                  
Arg Ser His Asn Lys Ser Arg Asp Arg Lys Arg Ser Arg Ser Arg Asp
65                  70                  75                  80  
Arg Asp Arg Tyr Arg Arg Arg Asn Ser Arg Ser Arg Ser Pro Gly Arg
                85                  90                  95      
Gln Cys Arg His Arg Ser Arg Ser Trp Asp Arg Arg His Gly Ser Glu
            100                 105                 110         
Ser Arg Ser Arg Asp His Arg Arg Glu Asp Arg Val His Tyr Arg Ser
        115                 120                 125             
Pro Pro Leu Ala Thr Gly Tyr Arg Tyr Gly His Ser Lys Ser Pro His
    130                 135                 140                 
Phe Arg Glu Lys Ser Pro Val Arg Glu Pro Val Asp Asn Leu Ser Pro
145                 150                 155                 160 
Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu Ala Ala Arg
                165                 170                 175     
Ile Arg Pro Arg Asp Leu Glu Asp Phe Phe Ser Ala Val Gly Lys Val
            180                 185                 190         
Arg Asp Val Arg Ile Ile Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly
        195                 200                 205             
Ile Ala Tyr Val Glu Phe Cys Glu Ile Gln Ser Val Pro Leu Ala Ile
    210                 215                 220                 
Gly Leu Thr Gly Gln Arg Leu Leu Gly Val Pro Ile Ile Val Gln Ala
225                 230                 235                 240 
Ser Gln Ala Glu Lys Asn Arg Leu Ala Ala Met Ala Asn Asn Leu Gln
                245                 250                 255     
Lys Gly Asn Gly Gly Pro Met Arg Leu Tyr Val Gly Ser Leu His Phe
            260                 265                 270         
Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro Phe Gly Lys
        275                 280                 285             
Ile Asp Asn Ile Val Leu Met Lys Asp Ser Asp Thr Gly Arg Ser Lys
    290                 295                 300                 
Gly Tyr Gly Phe Ile Thr Leu His Pro Pro Pro Leu Gly Thr Val
305                 310                 315                 


<210> 6962
<211> 439
<212> PRT
<213> Homo sapiens

<400> 6962
Met Ala Ser Asp Asp Phe Asp Ile Val Ile Glu Ala Met Leu Glu Ala
 1               5                  10                  15      
Pro Tyr Lys Lys Glu Glu Asp Glu Gln Gln Arg Lys Glu Val Lys Lys
            20                  25                  30          
Asp Tyr Pro Ser Asn Thr Thr Ser Ser Thr Ser Asn Ser Gly Asn Glu
        35                  40                  45              
Thr Ser Gly Ser Ser Thr Ile Gly Glu Thr Ser Lys Lys Lys Arg Ser
    50                  55                  60                  
Arg Ser His Asn Lys Ser Arg Asp Arg Lys Arg Ser Arg Ser Arg Asp
65                  70                  75                  80  
Arg Asp Arg Tyr Arg Arg Arg Asn Ser Arg Ser Arg Ser Pro Gly Arg
                85                  90                  95      
Gln Cys Arg His Arg Ser Arg Ser Trp Asp Arg Arg His Gly Ser Glu
            100                 105                 110         
Ser Arg Ser Arg Asp His Arg Arg Glu Asp Arg Val His Tyr Arg Ser
        115                 120                 125             
Pro Pro Leu Ala Thr Gly Tyr Arg Tyr Gly His Ser Lys Ser Pro His
    130                 135                 140                 
Phe Arg Glu Lys Ser Pro Val Arg Glu Pro Val Asp Asn Leu Ser Pro
145                 150                 155                 160 
Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu Ala Ala Arg
                165                 170                 175     
Ile Arg Pro Arg Asp Leu Glu Asp Phe Phe Ser Ala Val Gly Lys Val
            180                 185                 190         
Arg Asp Val Arg Ile Ile Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly
        195                 200                 205             
Ile Ala Tyr Val Glu Phe Cys Glu Ile Gln Ser Val Pro Leu Ala Ile
    210                 215                 220                 
Gly Leu Thr Gly Gln Arg Leu Leu Gly Val Pro Ile Ile Val Gln Ala
225                 230                 235                 240 
Ser Gln Ala Glu Lys Asn Arg Leu Ala Ala Met Ala Asn Asn Leu Gln
                245                 250                 255     
Lys Gly Asn Gly Gly Pro Met Arg Leu Tyr Val Gly Ser Leu His Phe
            260                 265                 270         
Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro Phe Gly Lys
        275                 280                 285             
Ile Asp Asn Ile Val Leu Met Lys Asp Ser Asp Thr Gly Arg Ser Lys
    290                 295                 300                 
Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala Arg Arg Ala
305                 310                 315                 320 
Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro Met Arg Val
                325                 330                 335     
Gly His Val Thr Glu Arg Leu Asp Gly Gly Thr Asp Ile Thr Phe Pro
            340                 345                 350         
Asp Gly Asp Gln Glu Leu Asp Leu Gly Ser Ala Gly Gly Arg Phe Gln
        355                 360                 365             
Leu Met Ala Lys Leu Ala Glu Gly Ala Gly Ile Gln Leu Pro Ser Thr
    370                 375                 380                 
Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Ala Ala Ala Leu Gln Leu
385                 390                 395                 400 
Asn Gly Ala Val Pro Leu Gly Ala Leu Asn Pro Ala Ala Leu Thr Ala
                405                 410                 415     
Leu Ser Pro Ala Leu Asn Leu Ala Ser Gln Cys Phe Gln Leu Ser Ser
            420                 425                 430         
Leu Phe Thr Pro Gln Thr Met
        435                 


<210> 6963
<211> 336
<212> PRT
<213> Homo sapiens

<400> 6963
Met Val Thr Ala Phe Arg Ser Leu Pro Arg Gly Ser Ser Gly Ala Ala
 1               5                  10                  15      
Ala Ser Met Ser Ala His Asn Arg Gly Thr Glu Leu Asp Leu Ser Trp
            20                  25                  30          
Ile Ser Lys Ile Gln Val Asn His Pro Ala Val Leu Arg Arg Ala Glu
        35                  40                  45              
Gln Ile Gln Ala Arg Arg Thr Val Lys Lys Glu Trp Gln Ala Ala Trp
    50                  55                  60                  
Leu Leu Lys Ala Val Thr Phe Ile Asp Leu Thr Thr Leu Ser Gly Asp
65                  70                  75                  80  
Asp Thr Ser Ser Asn Ile Gln Arg Leu Cys Tyr Lys Ala Lys Tyr Pro
                85                  90                  95      
Ile Arg Glu Asp Leu Leu Lys Ala Leu Asn Met His Asp Lys Gly Ile
            100                 105                 110         
Thr Thr Ala Ala Val Cys Val Tyr Pro Ala Arg Val Cys Asp Ala Val
        115                 120                 125             
Lys Ala Leu Lys Ala Ala Gly Cys Asn Ile Pro Val Ala Ser Val Ala
    130                 135                 140                 
Ala Gly Phe Pro Ala Gly Gln Thr His Leu Lys Thr Arg Leu Glu Glu
145                 150                 155                 160 
Ile Arg Leu Ala Val Glu Asp Gly Ala Thr Glu Ile Asp Val Val Ile
                165                 170                 175     
Asn Arg Ser Leu Val Leu Thr Gly Gln Trp Glu Ala Leu Tyr Asp Glu
            180                 185                 190         
Ile Arg Gln Phe Arg Lys Ala Cys Gly Glu Ala His Leu Lys Thr Ile
        195                 200                 205             
Leu Ala Thr Gly Glu Leu Gly Thr Leu Thr Asn Val Tyr Lys Ala Ser
    210                 215                 220                 
Met Ile Ala Met Met Ala Gly Ser Asp Phe Ile Lys Thr Ser Thr Gly
225                 230                 235                 240 
Lys Glu Thr Val Asn Ala Thr Phe Pro Val Ala Ile Val Met Leu Arg
                245                 250                 255     
Ala Ile Arg Asp Phe Phe Trp Lys Thr Gly Asn Lys Ile Gly Phe Lys
            260                 265                 270         
Pro Ala Gly Gly Ile Arg Ser Ala Lys Asp Ser Leu Ala Trp Leu Ser
        275                 280                 285             
Leu Val Lys Glu Glu Leu Gly Asp Glu Trp Leu Lys Pro Glu Leu Phe
    290                 295                 300                 
Arg Ile Gly Ala Ser Thr Leu Leu Ser Asp Ile Glu Arg Gln Ile Tyr
305                 310                 315                 320 
His His Val Thr Gly Arg Tyr Ala Ala Tyr His Asp Leu Pro Met Ser
                325                 330                 335     


<210> 6964
<211> 230
<212> PRT
<213> Homo sapiens

<400> 6964
Met Cys Gly Asn Asn Met Ser Thr Pro Leu Pro Ala Ile Val Pro Ala
 1               5                  10                  15      
Ala Arg Lys Ala Thr Ala Ala Val Ile Phe Leu His Gly Leu Gly Asp
            20                  25                  30          
Thr Gly His Gly Trp Ala Glu Ala Phe Ala Gly Ile Arg Ser Ser His
        35                  40                  45              
Ile Lys Tyr Ile Cys Pro His Ala Pro Val Arg Pro Val Thr Leu Asn
    50                  55                  60                  
Met Asn Val Ala Met Pro Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro
65                  70                  75                  80  
Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Asn Ile
                85                  90                  95      
Lys Ala Leu Ile Asp Gln Glu Val Lys Asn Gly Ile Pro Ser Asn Arg
            100                 105                 110         
Ile Ile Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr
        115                 120                 125             
Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys
    130                 135                 140                 
Trp Leu Pro Leu Arg Ala Ser Phe Pro Gln Gly Pro Ile Gly Gly Ala
145                 150                 155                 160 
Asn Arg Asp Ile Ser Ile Leu Gln Cys His Gly Asp Cys Asp Pro Leu
                165                 170                 175     
Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Lys Leu Lys Thr Leu
            180                 185                 190         
Val Asn Pro Ala Asn Val Thr Phe Lys Thr Tyr Glu Gly Met Met His
        195                 200                 205             
Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Gln Phe Ile Asp Lys
    210                 215                 220                 
Leu Leu Pro Pro Ile Asp
225                 230 


<210> 6965
<211> 61
<212> PRT
<213> Homo sapiens

<400> 6965
Met Asp Pro Asn Cys Ser Cys Ala Ala Ser Asp Ser Cys Thr Cys Ala
 1               5                  10                  15      
Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser
            20                  25                  30          
Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys
        35                  40                  45              
Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser Cys Cys Ala
    50                  55                  60      


<210> 6966
<211> 756
<212> PRT
<213> Homo sapiens

<400> 6966
Met His Leu Lys Ile Val Leu Ala Phe Leu Ala Leu Ser Leu Ile Thr
 1               5                  10                  15      
Ile Phe Ala Leu Ala Tyr Val Leu Leu Thr Ser Pro Gly Gly Ser Ser
            20                  25                  30          
Gln Pro Pro His Cys Pro Ser Val Ser His Arg Ala Gln Pro Trp Pro
        35                  40                  45              
His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser Arg Glu Glu Leu
    50                  55                  60                  
Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly Pro Gly Leu Val
65                  70                  75                  80  
Asp Ala Ala Gln Ala Gln Pro Ser Asp Asn Cys Ile Phe Ser Val Glu
                85                  90                  95      
Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His Leu Asp Arg Gly
            100                 105                 110         
Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val Leu Phe Gly Gly
        115                 120                 125             
Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly Pro Leu Pro His
    130                 135                 140                 
Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His Gly Gly Pro Leu
145                 150                 155                 160 
Pro Tyr His Arg Arg Pro Val Leu Arg Ala Glu Phe Thr Gln Met Trp
                165                 170                 175     
Arg His Leu Lys Asp Val Glu Leu Pro Lys Ala Pro Ile Phe Leu Ser
            180                 185                 190         
Ser Thr Phe Asn Tyr Asn Gly Ser Thr Leu Ala Ala Val His Ala Thr
        195                 200                 205             
Pro Arg Gly Leu Arg Ser Arg Glu Arg Thr Thr Trp Met Ala Leu Tyr
    210                 215                 220                 
His Asn Ile Ser Gly Val Gly Leu Phe Leu His Pro Val Gly Leu Glu
225                 230                 235                 240 
Leu Leu Leu Asp His Arg Ala Leu Asp Pro Ala His Trp Thr Val Gln
                245                 250                 255     
Gln Val Phe Tyr Leu Gly His Tyr Tyr Ala Asp Leu Gly Gln Leu Glu
            260                 265                 270         
Arg Glu Phe Lys Ser Gly Arg Leu Glu Val Val Arg Val Pro Leu Pro
        275                 280                 285             
Pro Pro Asn Gly Ala Ser Ser Leu Arg Ser Arg Asn Ser Pro Gly Pro
    290                 295                 300                 
Leu Pro Pro Leu Gln Phe Ser Pro Gln Gly Ser Gln Tyr Ser Val Gln
305                 310                 315                 320 
Gly Asn Leu Val Val Ser Ser Leu Trp Ser Phe Thr Phe Gly His Gly
                325                 330                 335     
Val Phe Ser Gly Leu Arg Ile Phe Asp Val Arg Phe Gln Gly Glu Arg
            340                 345                 350         
Ile Ala Tyr Glu Val Ser Val Gln Glu Cys Val Ser Ile Tyr Gly Ala
        355                 360                 365             
Asp Ser Pro Lys Thr Met Leu Thr Arg Tyr Leu Asp Ser Ser Phe Gly
    370                 375                 380                 
Leu Gly Arg Asn Ser Arg Gly Leu Val Arg Gly Val Asp Cys Pro Tyr
385                 390                 395                 400 
Gln Ala Thr Met Val Asp Ile His Ile Leu Val Gly Lys Gly Ala Val
                405                 410                 415     
Gln Leu Leu Pro Gly Ala Val Cys Val Phe Glu Glu Ala Gln Gly Leu
            420                 425                 430         
Pro Leu Arg Arg His His Asn Tyr Leu Gln Asn His Phe Tyr Gly Gly
        435                 440                 445             
Leu Ala Ser Ser Ala Leu Val Val Arg Ser Val Ser Ser Val Gly Asn
    450                 455                 460                 
Tyr Asp Tyr Ile Trp Asp Phe Val Leu Tyr Pro Asn Gly Ala Leu Glu
465                 470                 475                 480 
Gly Arg Val His Ala Thr Gly Tyr Ile Asn Thr Ala Phe Leu Lys Gly
                485                 490                 495     
Gly Glu Glu Gly Leu Leu Phe Gly Asn Arg Val Gly Glu Arg Val Leu
            500                 505                 510         
Gly Thr Val His Thr His Ala Phe His Phe Lys Leu Asp Leu Asp Val
        515                 520                 525             
Ala Gly Leu Lys Asn Trp Val Val Ala Glu Asp Val Val Phe Lys Pro
    530                 535                 540                 
Val Ala Ala Pro Trp Asn Pro Glu His Trp Leu Gln Arg Pro Gln Leu
545                 550                 555                 560 
Thr Arg Gln Val Leu Gly Lys Glu Asp Leu Thr Ala Phe Ser Leu Gly
                565                 570                 575     
Ser Pro Leu Pro Arg Tyr Leu Tyr Leu Ala Ser Asn Gln Thr Asn Ala
            580                 585                 590         
Trp Gly His Gln Arg Gly Tyr Arg Ile Gln Ile His Ser Pro Leu Gly
        595                 600                 605             
Ile Gln Ile Pro Leu Glu Ser Asp Met Glu Arg Ala Leu Ser Trp Gly
    610                 615                 620                 
Arg Tyr Gln Leu Val Val Thr Gln Arg Lys Glu Glu Glu Ser Gln Ser
625                 630                 635                 640 
Ser Ser Ile Tyr His Gln Asn Asp Ile Trp Thr Pro Thr Val Thr Phe
                645                 650                 655     
Ala Asp Phe Ile Asn Asn Glu Thr Leu Leu Gly Glu Asp Leu Val Ala
            660                 665                 670         
Trp Val Thr Ala Ser Phe Leu His Ile Pro His Ala Glu Asp Ile Pro
        675                 680                 685             
Asn Thr Val Thr Leu Gly Asn Arg Val Gly Phe Leu Leu Arg Pro Tyr
    690                 695                 700                 
Asn Phe Phe Asp Glu Asp Pro Ser Ile Phe Ser Pro Gly Ser Val Tyr
705                 710                 715                 720 
Phe Glu Lys Gly Gln Asp Ala Gly Leu Cys Ser Ile Asn Pro Val Ala
                725                 730                 735     
Cys Leu Pro Asp Leu Ala Ala Cys Val Pro Asp Leu Pro Pro Phe Ser
            740                 745                 750         
Tyr His Gly Phe
        755     


<210> 6967
<211> 729
<212> PRT
<213> Homo sapiens

<400> 6967
Met His Leu Lys Ile Val Leu Ala Phe Leu Ala Leu Ser Leu Ile Thr
 1               5                  10                  15      
Ile Phe Ala Leu Ala Tyr Val Leu Leu Thr Ser Pro Gly Gly Ser Ser
            20                  25                  30          
Gln Pro Pro His Cys Pro Ser Val Ser His Arg Ala Gln Pro Trp Pro
        35                  40                  45              
His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser Arg Glu Glu Leu
    50                  55                  60                  
Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly Pro Gly Leu Val
65                  70                  75                  80  
Asp Ala Ala Gln Ala Gln Pro Ser Asp Asn Cys Ile Phe Ser Val Glu
                85                  90                  95      
Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His Leu Asp Arg Gly
            100                 105                 110         
Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val Leu Phe Gly Gly
        115                 120                 125             
Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly Pro Leu Pro His
    130                 135                 140                 
Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His Gly Gly Pro Leu
145                 150                 155                 160 
Pro Tyr His Arg Arg Pro Val Leu Arg Ala Glu Phe Thr Gln Met Trp
                165                 170                 175     
Arg His Leu Lys Asp Val Glu Leu Pro Lys Ala Pro Ile Phe Leu Ser
            180                 185                 190         
Ser Thr Phe Asn Tyr Asn Gly Ser Thr Leu Ala Ala Val His Ala Thr
        195                 200                 205             
Pro Arg Gly Leu Arg Ser Arg Glu Arg Thr Thr Trp Met Ala Leu Tyr
    210                 215                 220                 
His Asn Ile Ser Gly Val Gly Leu Phe Leu His Pro Val Gly Leu Glu
225                 230                 235                 240 
Leu Leu Leu Asp His Arg Ala Leu Asp Pro Ala His Trp Thr Val Gln
                245                 250                 255     
Gln Val Phe Tyr Leu Gly His Tyr Tyr Ala Asp Leu Gly Gln Leu Glu
            260                 265                 270         
Arg Glu Phe Lys Ser Gly Arg Leu Glu Val Val Arg Val Pro Leu Pro
        275                 280                 285             
Pro Pro Asn Gly Ala Ser Ser Leu Arg Ser Arg Asn Ser Pro Gly Pro
    290                 295                 300                 
Leu Pro Pro Leu Gln Phe Ser Pro Gln Gly Ser Gln Tyr Ser Val Gln
305                 310                 315                 320 
Gly Asn Leu Val Val Ser Ser Leu Trp Ser Phe Thr Phe Gly His Gly
                325                 330                 335     
Val Phe Ser Gly Leu Arg Ile Phe Asp Val Arg Phe Gln Gly Glu Arg
            340                 345                 350         
Ile Ala Tyr Glu Val Ser Val Gln Glu Cys Val Ser Ile Tyr Gly Ala
        355                 360                 365             
Asp Ser Pro Lys Thr Met Leu Thr Arg Tyr Leu Asp Ser Ser Phe Gly
    370                 375                 380                 
Leu Gly Arg Asn Ser Arg Gly Leu Val Arg Gly Val Asp Cys Pro Tyr
385                 390                 395                 400 
Gln Ala Thr Met Val Asp Ile His Ile Leu Val Gly Lys Gly Ala Val
                405                 410                 415     
Gln Leu Leu Pro Gly Ala Val Cys Val Phe Glu Glu Ala Gln Gly Leu
            420                 425                 430         
Pro Leu Arg Arg His His Asn Tyr Leu Gln Asn His Phe Tyr Gly Gly
        435                 440                 445             
Leu Ala Ser Ser Ala Leu Val Val Arg Ser Val Ser Ser Val Gly Asn
    450                 455                 460                 
Tyr Asp Tyr Ile Trp Asp Phe Val Leu Tyr Pro Asn Gly Ala Leu Glu
465                 470                 475                 480 
Gly Arg Val His Ala Thr Gly Tyr Ile Asn Thr Ala Phe Leu Lys Gly
                485                 490                 495     
Gly Glu Glu Gly Leu Leu Phe Gly Asn Arg Val Gly Glu Arg Val Leu
            500                 505                 510         
Gly Thr Val His Thr His Ala Phe His Phe Lys Leu Asp Leu Asp Val
        515                 520                 525             
Ala Gly Leu Lys Asn Trp Val Val Ala Glu Asp Val Val Phe Lys Pro
    530                 535                 540                 
Val Ala Ala Pro Trp Asn Pro Glu His Trp Leu Gln Arg Pro Gln Leu
545                 550                 555                 560 
Thr Arg Gln Val Leu Gly Lys Glu Asp Leu Thr Ala Phe Ser Leu Gly
                565                 570                 575     
Ser Pro Leu Pro Arg Tyr Leu Tyr Leu Ala Ser Asn Gln Thr Asn Ala
            580                 585                 590         
Trp Gly His Gln Arg Gly Tyr Gln Leu Val Val Thr Gln Arg Lys Glu
        595                 600                 605             
Glu Glu Ser Gln Ser Ser Ser Ile Tyr His Gln Asn Asp Ile Trp Thr
    610                 615                 620                 
Pro Thr Val Thr Phe Ala Asp Phe Ile Asn Asn Glu Thr Leu Leu Gly
625                 630                 635                 640 
Glu Asp Leu Val Ala Trp Val Thr Ala Ser Phe Leu His Ile Pro His
                645                 650                 655     
Ala Glu Asp Ile Pro Asn Thr Val Thr Leu Gly Asn Arg Val Gly Phe
            660                 665                 670         
Leu Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Ile Phe Ser
        675                 680                 685             
Pro Gly Ser Val Tyr Phe Glu Lys Gly Gln Asp Ala Gly Leu Cys Ser
    690                 695                 700                 
Ile Asn Pro Val Ala Cys Leu Pro Asp Leu Ala Ala Cys Val Pro Asp
705                 710                 715                 720 
Leu Pro Pro Phe Ser Tyr His Gly Phe
                725                 


<210> 6968
<211> 335
<212> PRT
<213> Homo sapiens

<400> 6968
Met Gly His Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu His Thr Cys
 1               5                  10                  15      
Val Pro Ala Ser Trp Gly Leu Arg Cys Met Gln Cys Lys Thr Asn Gly
            20                  25                  30          
Asp Cys Arg Val Glu Glu Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr
        35                  40                  45              
Thr Ile Val Arg Leu Trp Glu Glu Gly Glu Glu Leu Glu Leu Val Glu
    50                  55                  60                  
Lys Ser Cys Thr His Ser Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg
65                  70                  75                  80  
Thr Gly Leu Lys Ile Thr Ser Leu Thr Glu Val Val Cys Gly Leu Asp
                85                  90                  95      
Leu Cys Asn Gln Gly Asn Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser
            100                 105                 110         
Arg Tyr Leu Glu Cys Ile Ser Cys Gly Ser Ser Asp Met Ser Cys Glu
        115                 120                 125             
Arg Gly Arg His Gln Ser Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys
    130                 135                 140                 
Leu Asp Val Val Thr His Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro
145                 150                 155                 160 
Lys Asp Asp Arg His Leu Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro
                165                 170                 175     
Gly Ser Asn Gly Phe His Asn Asn Asp Thr Phe His Phe Leu Lys Cys
            180                 185                 190         
Cys Asn Thr Thr Lys Cys Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn
        195                 200                 205             
Leu Pro Gln Asn Gly Arg Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr
    210                 215                 220                 
His Gly Cys Ser Ser Glu Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro
225                 230                 235                 240 
Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro Lys Asn Gln
                245                 250                 255     
Ser Tyr Met Val Arg Gly Cys Ala Thr Ala Ser Met Cys Gln His Ala
            260                 265                 270         
His Leu Gly Asp Ala Phe Ser Met Asn His Ile Asp Val Ser Cys Cys
        275                 280                 285             
Thr Lys Ser Gly Cys Asn His Pro Asp Leu Asp Val Gln Tyr Arg Ser
    290                 295                 300                 
Gly Ala Ala Pro Gln Pro Gly Pro Ala His Leu Ser Leu Thr Ile Thr
305                 310                 315                 320 
Leu Leu Met Thr Ala Arg Leu Trp Gly Gly Thr Leu Leu Trp Thr
                325                 330                 335 


<210> 6969
<211> 290
<212> PRT
<213> Homo sapiens

<400> 6969
Met Gly His Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu His Thr Cys
 1               5                  10                  15      
Val Pro Ala Ser Trp Gly Leu Arg Cys Met Gln Cys Lys Thr Asn Gly
            20                  25                  30          
Asp Cys Arg Val Glu Glu Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr
        35                  40                  45              
Thr Ile Val Arg Leu Trp Glu Glu Gly Glu Glu Leu Glu Leu Val Glu
    50                  55                  60                  
Lys Ser Cys Thr His Ser Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg
65                  70                  75                  80  
Thr Gly Leu Lys Ile Thr Ser Leu Thr Glu Val Val Cys Gly Leu Asp
                85                  90                  95      
Leu Cys Asn Gln Gly Asn Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser
            100                 105                 110         
Arg Tyr Leu Glu Cys Ile Ser Cys Gly Ser Ser Asp Met Ser Cys Glu
        115                 120                 125             
Arg Gly Arg His Gln Ser Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys
    130                 135                 140                 
Leu Asp Val Val Thr His Trp Ile Gln Glu Gly Glu Glu Ile Leu Glu
145                 150                 155                 160 
Leu Glu Asn Leu Pro Gln Asn Gly Arg Gln Cys Tyr Ser Cys Lys Gly
                165                 170                 175     
Asn Ser Thr His Gly Cys Ser Ser Glu Glu Thr Phe Leu Ile Asp Cys
            180                 185                 190         
Arg Gly Pro Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro
        195                 200                 205             
Lys Asn Gln Ser Tyr Met Val Arg Gly Cys Ala Thr Ala Ser Met Cys
    210                 215                 220                 
Gln His Ala His Leu Gly Asp Ala Phe Ser Met Asn His Ile Asp Val
225                 230                 235                 240 
Ser Cys Cys Thr Lys Ser Gly Cys Asn His Pro Asp Leu Asp Val Gln
                245                 250                 255     
Tyr Arg Ser Gly Ala Ala Pro Gln Pro Gly Pro Ala His Leu Ser Leu
            260                 265                 270         
Thr Ile Thr Leu Leu Met Thr Ala Arg Leu Trp Gly Gly Thr Leu Leu
        275                 280                 285             
Trp Thr
    290 


<210> 6970
<211> 803
<212> PRT
<213> Homo sapiens

<400> 6970
Asp Ile Arg Ile Arg Val Ala Ile Pro Leu Asp Tyr Glu Thr Val Asp
 1               5                  10                  15      
Arg Tyr Asp Phe Asp Leu Phe Ala Asn Glu Ser Val Pro Asp His Val
            20                  25                  30          
Gly Tyr Ala Lys Val Lys Ile Thr Leu Ile Asn Glu Asn Asp Asn Arg
        35                  40                  45              
Pro Ile Phe Ser Gln Pro Leu Tyr Asn Ile Ser Leu Tyr Glu Asn Val
    50                  55                  60                  
Thr Val Gly Thr Ser Val Leu Thr Val Leu Ala Thr Asp Asn Asp Ala
65                  70                  75                  80  
Gly Thr Phe Gly Glu Val Asn Tyr Phe Phe Ser Asp Asp Pro Asp Arg
                85                  90                  95      
Phe Ser Leu Asp Lys Asp Thr Gly Leu Ile Met Leu Ile Ala Arg Leu
            100                 105                 110         
Asp Tyr Glu Leu Ile Gln Arg Phe Thr Leu Thr Ile Ile Ala Arg Asp
        115                 120                 125             
Gly Gly Gly Glu Glu Thr Thr Gly Arg Val Arg Ile Asn Val Leu Asp
    130                 135                 140                 
Val Asn Asp Asn Val Pro Thr Phe Gln Lys Asp Ala Tyr Val Gly Ala
145                 150                 155                 160 
Leu Arg Glu Asn Glu Pro Ser Val Thr Gln Leu Val Arg Leu Arg Ala
                165                 170                 175     
Thr Asp Glu Asp Ser Pro Pro Asn Asn Gln Ile Thr Tyr Ser Ile Val
            180                 185                 190         
Ser Ala Ser Ala Phe Gly Ser Tyr Phe Asp Ile Ser Leu Tyr Glu Gly
        195                 200                 205             
Tyr Gly Val Ile Ser Val Ser Arg Pro Leu Asp Tyr Glu Gln Ile Ser
    210                 215                 220                 
Asn Gly Leu Ile Tyr Leu Thr Val Met Ala Met Asp Ala Gly Asn Pro
225                 230                 235                 240 
Pro Leu Asn Ser Thr Val Pro Val Thr Ile Glu Val Phe Asp Glu Asn
                245                 250                 255     
Asp Asn Pro Pro Thr Phe Ser Lys Pro Ala Tyr Phe Val Ser Val Val
            260                 265                 270         
Glu Asn Ile Met Ala Gly Ala Thr Val Leu Phe Leu Asn Ala Thr Asp
        275                 280                 285             
Leu Asp Arg Ser Arg Glu Tyr Gly Gln Glu Ser Ile Ile Tyr Ser Leu
    290                 295                 300                 
Glu Gly Ser Thr Gln Phe Arg Ile Asn Ala Arg Ser Gly Glu Ile Thr
305                 310                 315                 320 
Thr Thr Ser Leu Leu Asp Arg Glu Thr Lys Ser Glu Tyr Ile Leu Ile
                325                 330                 335     
Val Arg Ala Val Asp Gly Gly Val Gly His Asn Gln Lys Thr Gly Ile
            340                 345                 350         
Ala Thr Val Asn Ile Thr Leu Leu Asp Ile Asn Asp Asn His Pro Thr
        355                 360                 365             
Trp Lys Asp Ala Pro Tyr Tyr Ile Asn Leu Val Glu Met Thr Pro Pro
    370                 375                 380                 
Asp Ser Asp Val Thr Thr Val Val Ala Val Asp Pro Asp Leu Gly Glu
385                 390                 395                 400 
Asn Gly Thr Leu Val Tyr Ser Ile Gln Pro Pro Asn Lys Phe Tyr Ser
                405                 410                 415     
Leu Asn Ser Thr Thr Gly Lys Ile Arg Thr Thr His Ala Met Leu Asp
            420                 425                 430         
Arg Glu Asn Pro Asp Pro His Glu Ala Glu Leu Met Arg Lys Ile Val
        435                 440                 445             
Val Ser Val Thr Asp Cys Gly Arg Pro Pro Leu Lys Ala Thr Ser Ser
    450                 455                 460                 
Ala Thr Val Phe Val Asn Leu Leu Asp Leu Asn Asp Asn Asp Pro Thr
465                 470                 475                 480 
Phe Gln Asn Leu Pro Phe Val Ala Glu Val Leu Glu Gly Ile Pro Ala
                485                 490                 495     
Gly Val Ser Ile Tyr Gln Val Val Ala Ile Asp Leu Asp Glu Gly Leu
            500                 505                 510         
Asn Gly Leu Val Ser Tyr Arg Met Pro Val Gly Met Pro Arg Met Asp
        515                 520                 525             
Phe Leu Ile Asn Ser Ser Ser Gly Val Val Val Thr Thr Thr Glu Leu
    530                 535                 540                 
Asp Arg Glu Arg Ile Ala Glu Tyr Gln Leu Arg Val Val Ala Ser Asp
545                 550                 555                 560 
Ala Gly Thr Pro Thr Lys Ser Ser Thr Ser Thr Leu Thr Ile His Val
                565                 570                 575     
Leu Asp Val Asn Asp Glu Thr Pro Thr Phe Phe Pro Ala Val Tyr Asn
            580                 585                 590         
Val Ser Val Ser Glu Asp Val Pro Arg Glu Phe Arg Val Val Trp Leu
        595                 600                 605             
Asn Cys Thr Asp Asn Asp Val Gly Leu Asn Ala Glu Leu Ser Tyr Phe
    610                 615                 620                 
Ile Thr Gly Gly Asn Val Asp Gly Lys Phe Ser Val Gly Tyr Arg Asp
625                 630                 635                 640 
Ala Val Val Arg Thr Val Val Gly Leu Asp Arg Glu Thr Thr Ala Ala
                645                 650                 655     
Tyr Met Leu Ile Leu Glu Ala Ile Asp Asn Gly Pro Val Gly Lys Arg
            660                 665                 670         
His Thr Gly Thr Ala Thr Val Phe Val Thr Val Leu Asp Val Asn Asp
        675                 680                 685             
Asn Arg Pro Ile Phe Leu Gln Ser Ser Tyr Glu Ala Ser Val Pro Glu
    690                 695                 700                 
Asp Ile Pro Glu Gly His Ser Ile Leu Gln Glu Glu Asp Leu Ala Ser
705                 710                 715                 720 
Pro Cys Ile Ser Pro Ala Pro Pro Arg Arg Ala Phe Gln Ser Ser Gly
                725                 730                 735     
Glu Lys Glu Thr Ser Gln Phe Pro Gly Lys Glu Leu Arg Arg Glu Pro
            740                 745                 750         
Gly Pro Ser Lys Ala Gln Asn Arg Ala Ala Phe Thr Glu Pro Leu Ala
        755                 760                 765             
Glu Ala Pro Leu Leu Gly Ser Lys Gln Ala Gln Glu Glu Arg Ala Pro
    770                 775                 780                 
Leu Pro Arg Glu Gln Ala Gln Gln Leu Gln Gly Ser Glu Gly Glu Lys
785                 790                 795                 800 
Gly Gly Pro
            


<210> 6971
<211> 818
<212> PRT
<213> Homo sapiens

<400> 6971
Asp Ile Arg Ile Arg Val Ala Ile Pro Leu Asp Tyr Glu Thr Val Asp
 1               5                  10                  15      
Arg Tyr Asp Phe Asp Leu Phe Ala Asn Glu Ser Val Pro Asp His Val
            20                  25                  30          
Gly Tyr Ala Lys Val Lys Ile Thr Leu Ile Asn Glu Asn Asp Asn Arg
        35                  40                  45              
Pro Ile Phe Ser Gln Pro Leu Tyr Asn Ile Ser Leu Tyr Glu Asn Val
    50                  55                  60                  
Thr Val Gly Thr Ser Val Leu Thr Val Leu Ala Thr Asp Asn Asp Ala
65                  70                  75                  80  
Gly Thr Phe Gly Glu Val Ser Tyr Phe Phe Ser Asp Asp Pro Asp Arg
                85                  90                  95      
Phe Ser Leu Asp Lys Asp Thr Gly Leu Ile Met Leu Ile Ala Arg Leu
            100                 105                 110         
Asp Tyr Glu Leu Ile Gln Arg Phe Thr Leu Thr Ile Ile Ala Arg Asp
        115                 120                 125             
Gly Gly Gly Glu Glu Thr Thr Gly Arg Val Arg Ile Asn Val Leu Asp
    130                 135                 140                 
Val Asn Asp Asn Val Pro Thr Phe Gln Lys Asp Ala Tyr Val Gly Ala
145                 150                 155                 160 
Leu Arg Glu Asn Glu Pro Ser Val Thr Gln Leu Val Arg Leu Arg Ala
                165                 170                 175     
Thr Asp Glu Asp Ser Pro Pro Asn Asn Gln Ile Thr Tyr Ser Ile Val
            180                 185                 190         
Ser Ala Ser Ala Phe Gly Ser Tyr Phe Asp Ile Ser Leu Tyr Glu Gly
        195                 200                 205             
Tyr Gly Val Ile Ser Val Ser Arg Pro Leu Asp Tyr Glu Gln Ile Ser
    210                 215                 220                 
Asn Gly Leu Ile Tyr Leu Thr Val Met Ala Met Asp Ala Gly Asn Pro
225                 230                 235                 240 
Pro Leu Asn Ser Thr Val Pro Val Thr Ile Glu Val Phe Asp Glu Asn
                245                 250                 255     
Asp Asn Pro Pro Thr Phe Ser Lys Pro Ala Tyr Phe Val Ser Val Val
            260                 265                 270         
Glu Asn Ile Met Ala Gly Ala Thr Val Leu Phe Leu Asn Ala Thr Asp
        275                 280                 285             
Leu Asp Arg Ser Arg Glu Tyr Gly Gln Glu Ser Ile Ile Tyr Ser Leu
    290                 295                 300                 
Glu Gly Ser Thr Gln Phe Arg Ile Asn Ala Arg Ser Gly Glu Ile Thr
305                 310                 315                 320 
Thr Thr Ser Leu Leu Asp Arg Glu Thr Lys Ser Glu Tyr Ile Leu Ile
                325                 330                 335     
Val Arg Ala Val Asp Gly Gly Val Gly His Asn Gln Lys Thr Gly Ile
            340                 345                 350         
Ala Thr Val Asn Ile Thr Leu Leu Asp Ile Asn Asp Asn His Pro Thr
        355                 360                 365             
Trp Lys Asp Ala Pro Tyr Tyr Ile Asn Leu Val Glu Met Thr Pro Pro
    370                 375                 380                 
Asp Ser Asp Val Thr Thr Val Val Ala Val Asp Pro Asp Leu Gly Glu
385                 390                 395                 400 
Asn Gly Thr Leu Val Tyr Ser Ile Gln Pro Pro Asn Lys Phe Tyr Ser
                405                 410                 415     
Leu Asn Ser Thr Thr Gly Lys Ile Arg Thr Thr His Ala Met Leu Asp
            420                 425                 430         
Arg Glu Asn Pro Asp Pro His Glu Ala Glu Leu Met Arg Lys Ile Val
        435                 440                 445             
Val Ser Val Thr Asp Cys Gly Arg Pro Pro Leu Lys Ala Thr Ser Ser
    450                 455                 460                 
Ala Thr Val Phe Val Asn Leu Leu Asp Leu Asn Asp Asn Asp Pro Thr
465                 470                 475                 480 
Phe Gln Asn Leu Pro Phe Val Ala Glu Val Leu Glu Gly Ile Pro Ala
                485                 490                 495     
Gly Val Ser Ile Tyr Gln Val Val Ala Ile Asp Leu Asp Glu Gly Leu
            500                 505                 510         
Asn Gly Leu Val Ser Tyr Arg Met Pro Val Gly Met Pro Arg Met Asp
        515                 520                 525             
Phe Leu Ile Asn Ser Ser Ser Gly Val Val Val Thr Thr Thr Glu Leu
    530                 535                 540                 
Asp Arg Glu Arg Ile Ala Glu Tyr Gln Leu Arg Val Val Ala Ser Asp
545                 550                 555                 560 
Ala Gly Thr Pro Thr Lys Ser Ser Thr Ser Thr Leu Thr Ile His Val
                565                 570                 575     
Leu Asp Val Asn Asp Glu Thr Pro Thr Phe Phe Pro Ala Val Tyr Asn
            580                 585                 590         
Val Ser Val Ser Glu Asp Val Pro Arg Glu Phe Arg Val Val Trp Leu
        595                 600                 605             
Asn Cys Thr Asp Asn Asp Val Gly Leu Asn Ala Glu Leu Ser Tyr Phe
    610                 615                 620                 
Ile Thr Gly Gly Asn Val Asp Gly Lys Phe Ser Val Gly Tyr Arg Asp
625                 630                 635                 640 
Ala Val Val Arg Thr Val Val Gly Leu Asp Arg Glu Thr Thr Ala Ala
                645                 650                 655     
Tyr Met Leu Ile Leu Glu Ala Ile Asp Asn Gly Pro Val Gly Lys Arg
            660                 665                 670         
His Thr Gly Thr Ala Thr Val Phe Val Thr Val Leu Asp Val Asn Asp
        675                 680                 685             
Asn Arg Pro Ile Phe Leu Gln Ser Ser Tyr Glu Ala Ser Val Pro Glu
    690                 695                 700                 
Asp Ile Pro Glu Gly His Ser Ile Leu Gln Ala Gly Cys Arg Ala Glu
705                 710                 715                 720 
Asp Arg Ala Leu Ala Pro His Lys Gln Glu Glu Asp Leu Ala Ser Pro
                725                 730                 735     
Cys Ile Ser Pro Ala Pro Pro Arg Arg Ala Phe Gln Ser Ser Gly Glu
            740                 745                 750         
Lys Glu Thr Ser Gln Phe Pro Gly Lys Glu Leu Arg Arg Glu Pro Gly
        755                 760                 765             
Pro Ser Lys Ala Gln Asn Arg Ala Ala Phe Thr Glu Pro Leu Ala Glu
    770                 775                 780                 
Ala Pro Leu Leu Gly Ser Lys Gln Ala Gln Glu Glu Arg Ala Pro Leu
785                 790                 795                 800 
Pro Arg Glu Gln Ala Gln Gln Leu Gln Gly Ser Glu Gly Glu Lys Gly
                805                 810                 815     
Gly Pro
        


<210> 6972
<211> 537
<212> PRT
<213> Homo sapiens

<400> 6972
Asp Tyr Glu Leu Ile Gln Arg Phe Thr Leu Thr Ile Ile Ala Arg Asp
 1               5                  10                  15      
Gly Gly Gly Glu Glu Thr Thr Gly Arg Val Arg Ile Asn Val Leu Asp
            20                  25                  30          
Val Asn Asp Asn Val Pro Thr Phe Gln Lys Asp Ala Tyr Val Gly Ala
        35                  40                  45              
Leu Arg Glu Asn Glu Pro Ser Val Thr Gln Leu Val Arg Leu Arg Ala
    50                  55                  60                  
Thr Asp Glu Asp Ser Pro Pro Asn Asn Gln Ile Thr Tyr Ser Ile Val
65                  70                  75                  80  
Ser Ala Ser Ala Phe Gly Ser Tyr Phe Asp Ile Ser Leu Tyr Glu Gly
                85                  90                  95      
Tyr Gly Val Ile Ser Val Ser Arg Pro Leu Asp Tyr Glu Gln Ile Ser
            100                 105                 110         
Asn Gly Leu Ile Tyr Leu Thr Val Met Ala Met Asp Ala Gly Asn Pro
        115                 120                 125             
Pro Leu Asn Ser Thr Val Pro Val Thr Ile Glu Val Phe Asp Glu Asn
    130                 135                 140                 
Asp Asn Pro Pro Thr Phe Ser Lys Pro Ala Tyr Phe Val Ser Val Val
145                 150                 155                 160 
Glu Asn Ile Met Ala Gly Ala Thr Val Leu Phe Leu Asn Ala Thr Asp
                165                 170                 175     
Leu Asp Arg Ser Arg Glu Tyr Gly Gln Glu Ser Ile Ile Tyr Ser Leu
            180                 185                 190         
Glu Gly Ser Thr Gln Phe Arg Ile Asn Ala Arg Ser Gly Glu Ile Thr
        195                 200                 205             
Thr Thr Ser Leu Leu Asp Arg Glu Thr Lys Ser Glu Tyr Ile Leu Ile
    210                 215                 220                 
Val Arg Ala Val Asp Gly Gly Val Gly His Asn Gln Lys Thr Gly Ile
225                 230                 235                 240 
Ala Thr Val Asn Ile Thr Leu Leu Asp Ile Asn Asp Asn His Pro Thr
                245                 250                 255     
Trp Lys Asp Ala Pro Tyr Tyr Ile Asn Leu Val Glu Met Thr Pro Pro
            260                 265                 270         
Asp Ser Asp Val Thr Thr Val Val Ala Val Asp Pro Asp Leu Gly Glu
        275                 280                 285             
Asn Gly Thr Leu Val Tyr Ser Ile Gln Pro Pro Asn Lys Phe Tyr Ser
    290                 295                 300                 
Leu Asn Ser Thr Thr Gly Lys Ile Arg Thr Thr His Ala Met Leu Asp
305                 310                 315                 320 
Arg Glu Asn Pro Asp Pro His Glu Ala Glu Leu Met Arg Lys Ile Val
                325                 330                 335     
Val Ser Val Thr Asp Cys Gly Arg Pro Pro Leu Lys Ala Thr Ser Ser
            340                 345                 350         
Ala Thr Val Phe Val Asn Leu Leu Asp Leu Asn Asp Asn Asp Pro Thr
        355                 360                 365             
Phe Gln Asn Leu Pro Phe Val Ala Glu Val Leu Glu Gly Ile Pro Ala
    370                 375                 380                 
Gly Val Ser Ile Tyr Gln Val Val Ala Ile Asp Leu Asp Glu Gly Leu
385                 390                 395                 400 
Asn Gly Leu Val Ser Tyr Arg Met Pro Val Gly Met Pro Arg Met Asp
                405                 410                 415     
Phe Leu Ile Asn Ser Ser Ser Gly Val Val Val Thr Thr Thr Glu Leu
            420                 425                 430         
Asp Arg Glu Arg Ile Ala Glu Tyr Gln Leu Arg Val Val Ala Ser Asp
        435                 440                 445             
Ala Gly Thr Pro Thr Lys Ser Ser Thr Ser Thr Leu Thr Ile His Gly
    450                 455                 460                 
Leu Ala Pro Ala Pro Val Leu Pro Arg Ser Ala Gly Cys Glu Arg Arg
465                 470                 475                 480 
Asp Ala His Leu Leu Pro Gly Arg Val Gln Cys Val Cys Val Arg Gly
                485                 490                 495     
Arg Ala Thr Arg Val Pro Gly Gly Leu Ala Glu Leu His Gly Gln Arg
            500                 505                 510         
Arg Gly Pro Gln Cys Arg Ala Gln Leu Leu His His Arg Trp Gln Arg
        515                 520                 525             
Gly Trp Glu Val Gln Arg Gly Leu Pro
    530                 535         


<210> 6973
<211> 373
<212> PRT
<213> Homo sapiens

<400> 6973
Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr
 1               5                  10                  15      
Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg
            20                  25                  30          
Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg
        35                  40                  45              
Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly
    50                  55                  60                  
Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu
65                  70                  75                  80  
Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr
                85                  90                  95      
Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val
            100                 105                 110         
Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser
        115                 120                 125             
Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys
    130                 135                 140                 
Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His
145                 150                 155                 160 
Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly
                165                 170                 175     
Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu
            180                 185                 190         
Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val
        195                 200                 205             
Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val
    210                 215                 220                 
Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg
225                 230                 235                 240 
Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser
                245                 250                 255     
Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu
            260                 265                 270         
Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser
        275                 280                 285             
Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr
    290                 295                 300                 
Pro Thr Phe Phe Pro Ala Val Tyr Asn Val Ser Val Ser Glu Asp Val
305                 310                 315                 320 
Pro Arg Glu Phe Arg Val Val Trp Leu Asn Cys Thr Asp Asn Asp Val
                325                 330                 335     
Gly Leu Asn Ala Glu Leu Ser Tyr Phe Ile Thr Gly Ala Ala Pro Ala
            340                 345                 350         
Ser Thr His Leu Cys Arg Pro Pro Gly Ala Leu Pro Pro Pro Leu Pro
        355                 360                 365             
Asp Gly Gln Pro Asp
    370             


<210> 6974
<211> 794
<212> PRT
<213> Homo sapiens

<400> 6974
Met Arg Val Arg Ile Gly Leu Thr Leu Leu Leu Cys Ala Val Leu Leu
 1               5                  10                  15      
Ser Leu Ala Ser Ala Ser Ser Asp Glu Glu Gly Ser Gln Asp Glu Ser
            20                  25                  30          
Leu Asp Ser Lys Thr Thr Leu Thr Ser Asp Glu Ser Val Lys Asp His
        35                  40                  45              
Thr Thr Ala Gly Arg Val Val Ala Gly Gln Ile Phe Leu Asp Ser Glu
    50                  55                  60                  
Glu Ser Glu Leu Glu Ser Ser Ile Gln Glu Glu Glu Asp Ser Leu Lys
65                  70                  75                  80  
Ser Gln Glu Gly Glu Ser Val Thr Glu Asp Ile Ser Phe Leu Glu Ser
                85                  90                  95      
Pro Asn Pro Glu Asn Lys Asp Tyr Glu Glu Pro Lys Lys Val Arg Lys
            100                 105                 110         
Pro Ala Leu Thr Ala Ile Glu Gly Thr Ala His Gly Glu Pro Cys His
        115                 120                 125             
Phe Pro Phe Leu Phe Leu Asp Lys Glu Tyr Asp Glu Cys Thr Ser Asp
    130                 135                 140                 
Gly Arg Glu Asp Gly Arg Leu Trp Cys Ala Thr Thr Tyr Asp Tyr Lys
145                 150                 155                 160 
Ala Asp Glu Lys Trp Gly Phe Cys Glu Thr Glu Glu Glu Ala Ala Lys
                165                 170                 175     
Arg Arg Gln Met Gln Glu Ala Glu Met Met Tyr Gln Thr Gly Met Lys
            180                 185                 190         
Ile Leu Asn Gly Ser Asn Lys Lys Ser Gln Lys Arg Glu Ala Tyr Arg
        195                 200                 205             
Tyr Leu Gln Lys Ala Ala Ser Met Asn His Thr Lys Ala Leu Glu Arg
    210                 215                 220                 
Val Ser Tyr Ala Leu Leu Phe Gly Asp Tyr Leu Pro Gln Asn Ile Gln
225                 230                 235                 240 
Ala Ala Arg Glu Met Phe Glu Lys Leu Thr Glu Glu Gly Ser Pro Lys
                245                 250                 255     
Gly Gln Thr Ala Leu Gly Phe Leu Tyr Ala Ser Gly Leu Gly Val Asn
            260                 265                 270         
Ser Ser Gln Ala Lys Ala Leu Val Tyr Tyr Thr Phe Gly Ala Leu Gly
        275                 280                 285             
Gly Asn Leu Ile Ala His Met Val Leu Gly Tyr Arg Tyr Trp Ala Gly
    290                 295                 300                 
Ile Gly Val Leu Gln Ser Cys Glu Ser Ala Leu Thr His Tyr Arg Leu
305                 310                 315                 320 
Val Ala Asn His Val Ala Ser Asp Ile Ser Leu Thr Gly Gly Ser Val
                325                 330                 335     
Val Gln Arg Ile Arg Leu Pro Asp Glu Val Glu Asn Pro Gly Met Asn
            340                 345                 350         
Ser Gly Met Leu Glu Glu Asp Leu Ile Gln Tyr Tyr Gln Phe Leu Ala
        355                 360                 365             
Glu Lys Gly Asp Val Gln Ala Gln Val Gly Leu Gly Gln Leu His Leu
    370                 375                 380                 
His Gly Gly Arg Gly Val Glu Gln Asn His Gln Arg Ala Phe Asp Tyr
385                 390                 395                 400 
Phe Asn Leu Ala Ala Asn Ala Gly Asn Ser His Ala Met Ala Phe Leu
                405                 410                 415     
Gly Lys Met Tyr Ser Glu Gly Ser Asp Ile Val Pro Gln Ser Asn Glu
            420                 425                 430         
Thr Ala Leu His Tyr Phe Lys Lys Ala Ala Asp Met Gly Asn Pro Val
        435                 440                 445             
Gly Gln Ser Gly Leu Gly Met Ala Tyr Leu Tyr Gly Arg Gly Val Gln
    450                 455                 460                 
Val Asn Tyr Asp Leu Ala Leu Lys Tyr Phe Gln Lys Ala Ala Glu Gln
465                 470                 475                 480 
Gly Trp Val Asp Gly Gln Leu Gln Leu Gly Ser Met Tyr Tyr Asn Gly
                485                 490                 495     
Ile Gly Val Lys Arg Asp Tyr Lys Gln Ala Leu Lys Tyr Phe Asn Leu
            500                 505                 510         
Ala Ser Gln Gly Gly His Ile Leu Ala Phe Tyr Asn Leu Ala Gln Met
        515                 520                 525             
His Ala Ser Gly Thr Gly Val Met Arg Ser Cys His Thr Ala Val Glu
    530                 535                 540                 
Leu Phe Lys Asn Val Cys Glu Arg Gly Arg Trp Ser Glu Arg Leu Met
545                 550                 555                 560 
Thr Ala Tyr Asn Ser Tyr Lys Asp Gly Asp Tyr Asn Ala Ala Val Ile
                565                 570                 575     
Gln Tyr Leu Leu Leu Ala Glu Gln Gly Tyr Glu Val Ala Gln Ser Asn
            580                 585                 590         
Ala Ala Phe Ile Leu Asp Gln Arg Glu Ala Ser Ile Val Gly Glu Asn
        595                 600                 605             
Glu Thr Tyr Pro Arg Ala Leu Leu His Trp Asn Arg Ala Ala Ser Gln
    610                 615                 620                 
Gly Tyr Thr Val Ala Arg Ile Lys Leu Gly Asp Tyr His Phe Tyr Gly
625                 630                 635                 640 
Phe Gly Thr Asp Val Asp Tyr Glu Thr Ala Phe Ile His Tyr Arg Leu
                645                 650                 655     
Ala Ser Glu Gln Gln His Ser Ala Gln Ala Met Phe Asn Leu Gly Tyr
            660                 665                 670         
Met His Glu Lys Gly Leu Gly Ile Lys Gln Asp Ile His Leu Ala Lys
        675                 680                 685             
Arg Phe Tyr Asp Met Ala Ala Glu Ala Ser Pro Asp Ala Gln Val Pro
    690                 695                 700                 
Val Phe Leu Ala Leu Cys Lys Leu Gly Val Val Tyr Phe Leu Gln Tyr
705                 710                 715                 720 
Ile Arg Glu Thr Asn Ile Arg Asp Met Phe Thr Gln Leu Asp Met Asp
                725                 730                 735     
Gln Leu Leu Gly Pro Glu Trp Asp Leu Tyr Leu Met Thr Ile Ile Ala
            740                 745                 750         
Leu Leu Leu Gly Thr Val Ile Ala Tyr Arg Gln Arg Gln His Gln Asp
        755                 760                 765             
Met Pro Ala Pro Arg Pro Pro Gly Pro Arg Pro Ala Pro Pro Gln Gln
    770                 775                 780                 
Glu Gly Pro Pro Glu Gln Gln Pro Pro Gln
785                 790                 


<210> 6975
<211> 41
<212> PRT
<213> Homo sapiens

<400> 6975
Met Ser Ile Ser Leu Ala Trp Cys Gln Phe Leu Gln Val Asp Gly Thr
 1               5                  10                  15      
Ser Leu Pro Leu Asn His Leu Ser Lys Leu Gln Asp Ile Phe Tyr Pro
            20                  25                  30          
Asn Thr Ser Asn Cys Ala Lys Gly His
        35                  40      


<210> 6976
<211> 3241
<212> PRT
<213> Homo sapiens

<400> 6976
Met Glu Leu Val Gln Lys Glu Glu Gly Gly Glu Lys Gln Leu Lys Val
 1               5                  10                  15      
Ala Gln Phe Val Leu Lys Cys Ile Asp Asp Lys Asp Ser Thr Glu Lys
            20                  25                  30          
Glu Gly Phe Asp Ile Ile Leu Ala Gly Gln Thr Val His Asn Val Gly
        35                  40                  45              
Tyr Arg His Gln Ser Leu Glu Ser Gly Ile Ser His Ser Phe Gln Leu
    50                  55                  60                  
Asp Ser Gln Pro Arg Leu Gln Glu Asp Pro Ala Gly Asn Ala Arg Ser
65                  70                  75                  80  
Ser Trp His Phe Pro Ala Val Ser Leu Val Val Cys Pro Gly Thr Asp
                85                  90                  95      
Phe Ala Cys Ser Gln Ala Asp Leu Ser Lys Pro Glu His Arg Asp His
            100                 105                 110         
Ala Leu Ser Arg Asp Ser Arg Pro Ala Ala Phe Gly Arg Ala Leu Leu
        115                 120                 125             
Ser Pro Gly Leu Ala Gly Ala Ala Gly Val Pro Ala Glu Glu Ala Ile
    130                 135                 140                 
Val Leu Ala Asn Arg Gly Leu Arg Val Pro Phe Gly Arg Glu Val Trp
145                 150                 155                 160 
Leu Asp Pro Leu His Asp Leu Val Leu Gln Val Gln Pro Gly Asp Arg
                165                 170                 175     
Cys Ala Val Ser Val Leu Asp Asn Asp Ala Leu Ala Gln Arg Pro Gly
            180                 185                 190         
Arg Leu Ser Pro Lys Arg Phe Pro Cys Asp Phe Gly Pro Gly Glu Val
        195                 200                 205             
Arg Tyr Ser His Leu Gly Ala Arg Ser Pro Ser Arg Asp Arg Val Arg
    210                 215                 220                 
Leu Gln Leu Arg Tyr Asp Ala Pro Gly Gly Ala Val Val Leu Pro Leu
225                 230                 235                 240 
Val Leu Glu Val Glu Val Val Phe Thr Gln Leu Glu Val Val Thr Arg
                245                 250                 255     
Asn Leu Pro Leu Val Val Glu Glu Leu Leu Gly Thr Ser Asn Ala Leu
            260                 265                 270         
Asp Ala Arg Ser Leu Glu Phe Ala Phe Gln Pro Glu Thr Glu Glu Cys
        275                 280                 285             
Arg Val Gly Ile Leu Ser Gly Leu Gly Ala Leu Pro Arg Tyr Gly Glu
    290                 295                 300                 
Leu Leu His Tyr Pro Gln Val Pro Gly Gly Ala Arg Glu Gly Gly Ala
305                 310                 315                 320 
Pro Glu Thr Leu Leu Met Asp Cys Lys Ala Phe Gln Glu Leu Gly Val
                325                 330                 335     
Arg Tyr Arg His Thr Ala Ala Ser Arg Ser Pro Asn Arg Asp Trp Ile
            340                 345                 350         
Pro Met Val Val Glu Leu Arg Ser Arg Gly Ala Pro Val Gly Ser Pro
        355                 360                 365             
Ala Leu Lys Arg Glu His Phe Gln Val Leu Val Arg Ile Arg Gly Gly
    370                 375                 380                 
Ala Glu Asn Thr Ala Pro Lys Pro Ser Phe Val Ala Met Met Met Met
385                 390                 395                 400 
Glu Val Asp Gln Phe Val Leu Thr Ala Leu Thr Pro Asp Met Leu Ala
                405                 410                 415     
Ala Glu Asp Ala Glu Ser Pro Ser Asp Leu Leu Ile Phe Asn Leu Thr
            420                 425                 430         
Ser Pro Phe Gln Pro Gly Gln Gly Tyr Leu Val Ser Thr Asp Asp Arg
        435                 440                 445             
Ser Leu Pro Leu Ser Ser Phe Thr Gln Arg Asp Leu Arg Leu Leu Lys
    450                 455                 460                 
Ile Ala Tyr Gln Pro Pro Ser Glu Asp Ser Asp Gln Glu Arg Leu Phe
465                 470                 475                 480 
Glu Leu Glu Leu Glu Val Val Asp Leu Glu Gly Ala Ala Ser Asp Pro
                485                 490                 495     
Phe Ala Phe Met Val Val Val Lys Pro Met Asn Thr Met Ala Pro Val
            500                 505                 510         
Val Thr Arg Asn Thr Gly Leu Ile Leu Tyr Glu Gly Gln Ser Arg Pro
        515                 520                 525             
Leu Thr Gly Pro Ala Gly Ser Gly Pro Gln Asn Leu Val Ile Ser Asp
    530                 535                 540                 
Glu Asp Asp Leu Glu Ala Val Arg Leu Glu Val Val Ala Gly Leu Arg
545                 550                 555                 560 
His Gly His Leu Val Ile Leu Gly Ala Ser Ser Gly Ser Ser Ala Pro
                565                 570                 575     
Lys Ser Phe Thr Val Ala Glu Leu Ala Ala Gly Gln Val Val Tyr Gln
            580                 585                 590         
His Asp Asp Arg Asp Gly Ser Leu Ser Asp Asn Leu Val Leu Arg Met
        595                 600                 605             
Val Asp Gly Gly Gly Arg His Gln Val Gln Phe Leu Phe Pro Ile Thr
    610                 615                 620                 
Leu Val Pro Val Asp Asp Gln Pro Pro Val Leu Asn Ala Asn Thr Gly
625                 630                 635                 640 
Leu Thr Leu Ala Glu Gly Glu Thr Val Pro Ile Leu Pro Leu Ser Leu
                645                 650                 655     
Ser Ala Thr Asp Met Asp Ser Asp Asp Ser Leu Leu Leu Phe Val Leu
            660                 665                 670         
Glu Ser Pro Phe Leu Thr Thr Gly His Leu Leu Leu Arg Gln Thr His
        675                 680                 685             
Pro Pro His Glu Lys Gln Glu Leu Leu Arg Gly Leu Trp Arg Lys Glu
    690                 695                 700                 
Gly Ala Phe Tyr Glu Arg Thr Val Thr Glu Trp Gln Gln Gln Asp Ile
705                 710                 715                 720 
Thr Glu Gly Arg Leu Phe Tyr Arg His Ser Gly Pro His Ser Pro Gly
                725                 730                 735     
Pro Val Thr Asp Gln Phe Thr Phe Arg Val Gln Asp Asn His Asp Pro
            740                 745                 750         
Pro Asn Gln Ser Gly Leu Gln Arg Phe Val Ile Arg Ile His Pro Val
        755                 760                 765             
Asp Arg Leu Pro Pro Glu Leu Gly Ser Gly Cys Pro Leu Arg Met Val
    770                 775                 780                 
Val Gln Glu Ser Gln Leu Thr Pro Leu Arg Lys Lys Trp Leu Arg Tyr
785                 790                 795                 800 
Thr Asp Leu Asp Thr Asp Asp Arg Glu Leu Arg Tyr Thr Val Thr Gln
                805                 810                 815     
Ser Pro Thr Asp Thr Asp Glu Asn His Leu Pro Ala Pro Leu Gly Thr
            820                 825                 830         
Leu Val Leu Thr Asp Asn Pro Ser Val Val Val Thr His Phe Thr Gln
        835                 840                 845             
Ala Gln Ile Asn His His Lys Ile Ala Tyr Arg Pro Pro Gly Gln Glu
    850                 855                 860                 
Leu Gly Val Ala Thr Arg Val Ala Gln Phe Gln Phe Gln Val Glu Asp
865                 870                 875                 880 
Arg Ala Gly Asn Val Ala Pro Gly Thr Phe Thr Leu Tyr Leu His Pro
                885                 890                 895     
Val Asp Asn Gln Pro Pro Glu Ile Leu Asn Thr Gly Phe Thr Ile Gln
            900                 905                 910         
Glu Lys Gly His His Ile Leu Ser Glu Thr Glu Leu His Val Asn Asp
        915                 920                 925             
Val Asp Thr Asp Val Ala His Ile Ser Phe Thr Leu Thr Gln Ala Pro
    930                 935                 940                 
Lys His Gly His Met Arg Val Ser Gly Gln Ile Leu His Val Gly Gly
945                 950                 955                 960 
Leu Phe His Leu Glu Asp Ile Lys Gln Gly Arg Val Ser Tyr Ala His
                965                 970                 975     
Asn Gly Asp Lys Ser Leu Thr Asp Ser Cys Ser Leu Glu Val Ser Asp
            980                 985                 990         
Arg His His Val Val Pro Ile Thr Leu Arg Val Asn Val Arg Pro Val
        995                 1000                1005            
Asp Asp Glu Val Pro Ile Leu Ser His Pro Thr Gly Thr Leu Glu Ser
    1010                1015                1020                
Tyr Leu Asp Val Leu Glu Asn Gly Ala Thr Glu Ile Thr Ala Asn Val
1025                1030                1035                1040
Ile Lys Gly Thr Asn Glu Glu Thr Asp Asp Leu Met Leu Thr Phe Leu
                1045                1050                1055    
Leu Glu Asp Pro Pro Leu Tyr Gly Glu Ile Leu Val Asn Gly Ile Pro
            1060                1065                1070        
Ala Glu Gln Phe Thr Gln Arg Asp Ile Leu Glu Gly Ser Val Val Tyr
        1075                1080                1085            
Thr His Thr Ser Gly Glu Ile Gly Leu Leu Pro Lys Ala Asp Ser Phe
    1090                1095                1100                
Asn Leu Ser Leu Ser Asp Met Ser Gln Glu Trp Arg Ile Gly Gly Asn
1105                1110                1115                1120
Thr Ile Gln Gly Val Thr Ile Trp Val Thr Ile Leu Pro Val Asp Ser
                1125                1130                1135    
Gln Ala Pro Glu Ile Phe Val Gly Glu Gln Leu Ile Val Met Glu Gly
            1140                1145                1150        
Asp Lys Ser Val Ile Thr Ser Val His Ile Ser Ala Glu Asp Val Asp
        1155                1160                1165            
Ser Leu Asn Asp Asp Ile Leu Cys Thr Ile Val Ile Gln Pro Thr Ser
    1170                1175                1180                
Gly Tyr Val Glu Asn Ile Ser Pro Ala Pro Gly Ser Glu Lys Ser Arg
1185                1190                1195                1200
Ala Gly Ile Ala Ile Ser Ala Phe Asn Leu Lys Asp Leu Arg Gln Gly
                1205                1210                1215    
His Ile Asn Tyr Val Gln Ser Val His Lys Gly Val Glu Pro Val Glu
            1220                1225                1230        
Asp Arg Phe Val Phe Arg Cys Ser Asp Gly Ile Asn Phe Ser Glu Arg
        1235                1240                1245            
Gln Phe Phe Pro Ile Val Ile Ile Pro Thr Asn Asp Glu Gln Pro Glu
    1250                1255                1260                
Met Phe Met Arg Glu Phe Met Val Met Glu Gly Met Ser Leu Val Ile
1265                1270                1275                1280
Asp Thr Pro Ile Leu Asn Ala Ala Asp Ala Asp Val Pro Leu Asp Asp
                1285                1290                1295    
Leu Thr Phe Thr Ile Thr Gln Phe Pro Thr His Gly His Ile Met Asn
            1300                1305                1310        
Gln Leu Ile Asn Gly Thr Val Leu Val Glu Ser Phe Thr Leu Asp Gln
        1315                1320                1325            
Ile Ile Glu Ser Ser Ser Ile Ile Tyr Glu His Asp Asp Ser Glu Thr
    1330                1335                1340                
Gln Glu Asp Ser Phe Val Ile Lys Leu Thr Asp Gly Lys His Ser Val
1345                1350                1355                1360
Glu Lys Thr Val Leu Ile Ile Val Ile Pro Val Asp Asp Glu Thr Pro
                1365                1370                1375    
Arg Met Thr Ile Asn Asn Gly Leu Glu Ile Glu Ile Gly Asp Thr Lys
            1380                1385                1390        
Ile Ile Asn Asn Lys Ile Leu Met Ala Thr Asp Leu Asp Ser Glu Asp
        1395                1400                1405            
Lys Ser Leu Val Tyr Ile Ile Arg Tyr Gly Pro Gly His Gly Leu Leu
    1410                1415                1420                
Gln Arg Arg Lys Pro Thr Gly Ala Phe Glu Asn Ile Thr Leu Gly Met
1425                1430                1435                1440
Asn Phe Thr Gln Asp Glu Val Asp Arg Asn Leu Ile Gln Tyr Val His
                1445                1450                1455    
Leu Gly Gln Glu Gly Ile Arg Asp Leu Ile Lys Phe Asp Val Thr Asp
            1460                1465                1470        
Gly Ile Asn Pro Leu Ile Asp Arg Tyr Phe Tyr Val Ser Ile Gly Ser
        1475                1480                1485            
Ile Asp Ile Val Phe Pro Asp Val Ile Ser Lys Gly Val Ser Leu Lys
    1490                1495                1500                
Glu Gly Gly Lys Val Thr Leu Thr Thr Asp Leu Leu Ser Thr Ser Asp
1505                1510                1515                1520
Leu Asn Ser Pro Asp Glu Asn Leu Val Phe Thr Ile Thr Arg Ala Pro
                1525                1530                1535    
Met Arg Gly His Leu Glu Cys Thr Asp Gln Pro Gly Val Ser Ile Thr
            1540                1545                1550        
Ser Phe Thr Gln Leu Gln Leu Ala Gly Asn Lys Ile Tyr Tyr Ile His
        1555                1560                1565            
Thr Ala Asp Asp Glu Val Lys Met Asp Ser Phe Glu Phe Gln Val Thr
    1570                1575                1580                
Asp Gly Arg Asn Pro Val Phe Arg Thr Phe Arg Ile Ser Ile Ser Asp
1585                1590                1595                1600
Val Asp Asn Lys Lys Pro Val Val Thr Ile His Lys Leu Val Val Ser
                1605                1610                1615    
Glu Ser Glu Asn Lys Leu Ile Thr Pro Phe Glu Leu Thr Val Glu Asp
            1620                1625                1630        
Arg Asp Thr Pro Asp Lys Leu Leu Lys Phe Thr Ile Thr Gln Val Pro
        1635                1640                1645            
Ile His Gly His Leu Leu Phe Asn Asn Thr Arg Pro Val Met Val Phe
    1650                1655                1660                
Thr Lys Gln Asp Leu Asn Glu Asn Leu Ile Ser Tyr Lys His Asp Gly
1665                1670                1675                1680
Thr Glu Ser Ser Glu Asp Ser Phe Ser Phe Thr Val Thr Asp Gly Thr
                1685                1690                1695    
His Thr Asp Phe Tyr Val Phe Pro Asp Thr Val Phe Glu Thr Arg Arg
            1700                1705                1710        
Pro Gln Val Met Lys Ile Gln Val Leu Ala Val Asp Asn Ser Val Pro
        1715                1720                1725            
Gln Ile Ala Val Asn Lys Gly Ala Ser Thr Leu Arg Thr Leu Ala Thr
    1730                1735                1740                
Gly His Leu Gly Phe Met Ile Thr Ser Lys Ile Leu Lys Val Glu Asp
1745                1750                1755                1760
Arg Asp Ser Leu His Ile Ser Leu Arg Phe Ile Val Thr Glu Ala Pro
                1765                1770                1775    
Gln His Gly Tyr Leu Leu Asn Leu Asp Lys Gly Asn His Ser Ile Thr
            1780                1785                1790        
Gln Phe Thr Gln Ala Asp Ile Asp Asp Met Lys Ile Cys Tyr Val Leu
        1795                1800                1805            
Arg Glu Gly Ala Asn Ala Thr Ser Asp Met Phe Tyr Phe Ala Val Glu
    1810                1815                1820                
Asp Gly Gly Gly Asn Lys Leu Thr Tyr Gln Asn Phe Arg Leu Asn Trp
1825                1830                1835                1840
Ala Trp Ile Ser Phe Glu Lys Glu Tyr Tyr Leu Val Asn Glu Asp Ser
                1845                1850                1855    
Lys Phe Leu Asp Val Val Leu Lys Arg Arg Gly Tyr Leu Gly Glu Thr
            1860                1865                1870        
Ser Phe Ile Ser Ile Gly Thr Arg Asp Arg Thr Ala Glu Lys Asp Lys
        1875                1880                1885            
Asp Phe Lys Gly Lys Ala Gln Lys Gln Val Gln Phe Asn Pro Gly Gln
    1890                1895                1900                
Thr Arg Ala Thr Trp Arg Val Arg Ile Leu Ser Asp Gly Glu His Glu
1905                1910                1915                1920
Gln Ser Glu Thr Phe Gln Val Val Leu Ser Glu Pro Val Leu Ala Ala
                1925                1930                1935    
Leu Glu Phe Pro Thr Val Ala Thr Val Glu Ile Val Asp Pro Gly Asp
            1940                1945                1950        
Glu Pro Thr Val Phe Ile Pro Gln Ser Lys Tyr Ser Val Glu Glu Asp
        1955                1960                1965            
Val Gly Glu Leu Phe Ile Pro Ile Arg Arg Ser Gly Asp Val Ser Gln
    1970                1975                1980                
Glu Leu Met Val Val Cys Tyr Thr Gln Gln Gly Thr Ala Thr Gly Thr
1985                1990                1995                2000
Val Pro Thr Ser Val Leu Ser Tyr Ser Asp Tyr Ile Ser Arg Pro Glu
                2005                2010                2015    
Asp His Thr Ser Val Val Arg Phe Asp Lys Asp Glu Arg Glu Lys Leu
            2020                2025                2030        
Cys Arg Ile Val Ile Ile Asp Asp Ser Leu Tyr Glu Glu Glu Glu Thr
        2035                2040                2045            
Phe His Val Leu Leu Ser Met Pro Met Gly Gly Arg Ile Gly Ser Glu
    2050                2055                2060                
Phe Pro Gly Ala Gln Val Thr Ile Val Pro Asp Lys Asp Asp Glu Pro
2065                2070                2075                2080
Ile Phe Tyr Phe Gly Asp Val Glu Tyr Ser Val Asp Glu Ser Ala Gly
                2085                2090                2095    
Tyr Val Glu Val Gln Val Trp Arg Thr Gly Thr Asp Leu Ser Lys Ser
            2100                2105                2110        
Ser Ser Val Thr Val Arg Ser Arg Lys Thr Asp Pro Pro Ser Ala Asp
        2115                2120                2125            
Ala Gly Thr Asp Tyr Val Gly Ile Ser Arg Asn Leu Asp Phe Ala Pro
    2130                2135                2140                
Gly Val Asn Met Gln Pro Val Arg Val Val Ile Leu Asp Asp Leu Gly
2145                2150                2155                2160
Gln Pro Ala Leu Glu Gly Ile Glu Lys Phe Glu Leu Val Leu Arg Met
                2165                2170                2175    
Pro Met Asn Ala Ala Leu Gly Glu Pro Ser Lys Ala Thr Val Ser Ile
            2180                2185                2190        
Asn Asp Ser Val Ser Asp Leu Pro Lys Met Gln Phe Lys Glu Arg Ile
        2195                2200                2205            
Tyr Thr Gly Ser Glu Ser Asp Gly Gln Ile Val Thr Met Ile His Arg
    2210                2215                2220                
Thr Gly Asp Val Gln Tyr Arg Ser Ser Val Arg Cys Tyr Thr Arg Gln
2225                2230                2235                2240
Gly Ser Ala Gln Val Met Met Asp Phe Glu Glu Arg Pro Asn Thr Asp
                2245                2250                2255    
Thr Ser Ile Ile Thr Phe Leu Pro Gly Glu Thr Glu Lys Pro Cys Ile
            2260                2265                2270        
Leu Glu Leu Met Asp Asp Val Leu Tyr Glu Glu Val Glu Glu Leu Arg
        2275                2280                2285            
Leu Val Leu Gly Thr Pro Gln Ser Asn Ser Pro Phe Gly Ala Ala Val
    2290                2295                2300                
Gly Glu Gln Asn Glu Thr Leu Ile Arg Ile Arg Asp Asp Ala Asp Lys
2305                2310                2315                2320
Thr Val Ile Lys Phe Gly Glu Thr Lys Phe Ser Val Thr Glu Pro Lys
                2325                2330                2335    
Glu Pro Gly Glu Ser Val Val Ile Arg Ile Pro Val Ile Arg Gln Gly
            2340                2345                2350        
Asp Thr Ser Lys Val Ser Ile Val Arg Val His Thr Lys Asp Gly Ser
        2355                2360                2365            
Ala Thr Ser Gly Glu Asp Tyr His Pro Val Ser Glu Glu Ile Glu Phe
    2370                2375                2380                
Lys Glu Gly Glu Thr Gln His Val Val Glu Ile Glu Val Thr Phe Asp
2385                2390                2395                2400
Gly Val Arg Glu Met Arg Glu Ala Phe Thr Val His Leu Lys Pro Asp
                2405                2410                2415    
Glu Asn Met Ile Ala Glu Met Gln Leu Thr Lys Ala Ile Val Tyr Ile
            2420                2425                2430        
Glu Glu Met Ser Ser Met Ala Asp Val Thr Phe Pro Ser Val Pro Gln
        2435                2440                2445            
Ile Val Ser Leu Leu Met Tyr Asp Asp Thr Ser Lys Ala Lys Glu Ser
    2450                2455                2460                
Ala Glu Pro Met Ser Gly Tyr Pro Val Ile Cys Ile Thr Ala Cys Asn
2465                2470                2475                2480
Pro Lys Tyr Ser Asp Tyr Asp Lys Thr Gly Ser Ile Cys Ala Ser Glu
                2485                2490                2495    
Asn Ile Asn Asp Thr Leu Thr Arg Tyr Arg Trp Leu Ile Ser Ala Pro
            2500                2505                2510        
Ala Gly Pro Asp Gly Val Thr Ser Pro Met Arg Glu Val Asp Phe Asp
        2515                2520                2525            
Thr Phe Phe Thr Ser Ser Lys Met Val Thr Leu Asp Ser Ile Tyr Phe
    2530                2535                2540                
Gln Pro Gly Ser Arg Val Gln Cys Ala Ala Arg Ala Val Asn Thr Asn
2545                2550                2555                2560
Gly Asp Glu Gly Leu Glu Leu Met Ser Pro Ile Val Thr Ile Ser Arg
                2565                2570                2575    
Glu Glu Gly Leu Cys Gln Pro Arg Val Pro Gly Val Val Gly Ala Glu
            2580                2585                2590        
Pro Phe Ser Ala Lys Leu Arg Tyr Thr Gly Pro Glu Asp Ala Asp Tyr
        2595                2600                2605            
Thr Asn Leu Ile Lys Leu Thr Val Thr Met Pro His Ile Asp Gly Met
    2610                2615                2620                
Leu Pro Val Ile Ser Thr Arg Glu Leu Ser Asn Phe Glu Leu Thr Leu
2625                2630                2635                2640
Ser Pro Asp Gly Thr Arg Val Gly Asn His Lys Cys Ser Asn Leu Leu
                2645                2650                2655    
Asp Tyr Thr Glu Val Lys Thr His Tyr Gly Phe Leu Thr Asp Ala Thr
            2660                2665                2670        
Lys Asn Pro Glu Ile Ile Gly Glu Thr Tyr Pro Tyr Gln Tyr Ser Leu
        2675                2680                2685            
Ser Ile Arg Gly Ser Thr Thr Leu Arg Phe Tyr Arg Asn Leu Asn Leu
    2690                2695                2700                
Glu Ala Cys Leu Trp Glu Phe Val Ser Tyr Tyr Asp Met Ser Glu Leu
2705                2710                2715                2720
Leu Ala Asp Cys Gly Gly Thr Ile Gly Thr Asp Gly Gln Val Leu Asn
                2725                2730                2735    
Leu Val Gln Ser Tyr Val Thr Leu Arg Val Pro Leu Tyr Val Ser Tyr
            2740                2745                2750        
Val Phe His Ser Pro Val Gly Val Gly Gly Trp Gln His Phe Asp Leu
        2755                2760                2765            
Lys Ser Glu Leu Arg Leu Thr Phe Val Tyr Asp Thr Ala Ile Leu Trp
    2770                2775                2780                
Asn Asp Gly Ile Gly Ser Pro Pro Glu Ala Glu Leu Gln Gly Ser Leu
2785                2790                2795                2800
Tyr Pro Thr Ser Met Arg Ile Gly Asp Glu Gly Arg Leu Ala Val His
                2805                2810                2815    
Phe Lys Thr Glu Ala Gln Phe His Gly Leu Phe Val Leu Ser His Pro
            2820                2825                2830        
Ala Ser Phe Thr Ser Ser Val Ile Met Ser Ala Asp His Pro Gly Leu
        2835                2840                2845            
Thr Phe Ser Leu Arg Leu Ile Arg Ser Glu Pro Thr Tyr Asn Gln Pro
    2850                2855                2860                
Val Gln Gln Trp Ser Phe Val Ser Asp Phe Ala Val Arg Asp Tyr Ser
2865                2870                2875                2880
Gly Thr Tyr Thr Val Lys Leu Val Pro Cys Thr Ala Pro Ser His Gln
                2885                2890                2895    
Glu Tyr Arg Leu Pro Val Thr Cys Asn Pro Arg Glu Pro Val Thr Phe
            2900                2905                2910        
Asp Leu Asp Ile Arg Phe Gln Gln Val Ser Asp Pro Val Ala Ala Glu
        2915                2920                2925            
Phe Ser Leu Asn Thr Gln Met Tyr Leu Leu Ser Lys Lys Ser Leu Trp
    2930                2935                2940                
Leu Ser Asp Gly Ser Met Gly Phe Gly Gln Glu Ser Asp Val Ala Phe
2945                2950                2955                2960
Ala Glu Gly Asp Ile Ile Tyr Gly Arg Val Met Val Asp Pro Val Gln
                2965                2970                2975    
Asn Leu Gly Asp Ser Phe Tyr Cys Ser Ile Glu Lys Val Phe Leu Cys
            2980                2985                2990        
Thr Gly Ala Asp Gly Tyr Val Pro Lys Tyr Ser Pro Met Asn Ala Glu
        2995                3000                3005            
Tyr Gly Cys Leu Ala Asp Ser Pro Ser Leu Leu Tyr Arg Phe Lys Ile
    3010                3015                3020                
Val Asp Lys Ala Gln Pro Glu Thr Gln Ala Thr Ser Phe Gly Asn Val
3025                3030                3035                3040
Leu Phe Asn Ala Lys Leu Ala Val Asp Asp Pro Glu Ala Ile Leu Leu
                3045                3050                3055    
Val Asn Gln Pro Gly Ser Asp Gly Phe Lys Val Asp Ser Thr Pro Leu
            3060                3065                3070        
Phe Gln Val Ala Leu Gly Arg Glu Trp Tyr Ile His Thr Ile Tyr Thr
        3075                3080                3085            
Val Arg Ser Lys Asp Asn Ala Asn Arg Gly Ile Gly Lys Arg Ser Val
    3090                3095                3100                
Glu Tyr His Ser Leu Val Ser Gln Gly Lys Pro Gln Ser Thr Thr Lys
3105                3110                3115                3120
Ser Arg Lys Lys Arg Glu Ile Arg Ser Thr Pro Ser Leu Ala Trp Glu
                3125                3130                3135    
Ile Gly Ala Glu Asn Ser Arg Gly Thr Asn Ile Gln His Ile Ala Leu
            3140                3145                3150        
Asp Arg Thr Lys Arg Gln Ile Pro His Gly Arg Ala Pro Pro Asp Gly
        3155                3160                3165            
Ile Leu Pro Trp Glu Leu Asn Ser Pro Ser Ser Ala Val Ser Leu Val
    3170                3175                3180                
Thr Val Val Gly Gly Thr Thr Val Gly Leu Leu Thr Ile Cys Leu Thr
3185                3190                3195                3200
Val Ile Ala Val Leu Met Cys Arg Gly Lys Glu Ser Phe Arg Gly Lys
                3205                3210                3215    
Asp Ala Pro Lys Gly Ser Ser Ser Ser Glu Pro Met Val Pro Pro Gln
            3220                3225                3230        
Ser His His Asn Asp Ser Ser Glu Val
        3235                3240    


<210> 6977
<211> 101
<212> PRT
<213> Homo sapiens

<400> 6977
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val
 1               5                  10                  15      
Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
            20                  25                  30          
Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
        35                  40                  45              
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
    50                  55                  60                  
Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
65                  70                  75                  80  
Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
                85                  90                  95      
Ala Ala Tyr Arg Ser
            100     


<210> 6978
<211> 220
<212> PRT
<213> Homo sapiens

<400> 6978
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val
 1               5                  10                  15      
Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
            20                  25                  30          
Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
        35                  40                  45              
Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
    50                  55                  60                  
Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
65                  70                  75                  80  
Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                85                  90                  95      
Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
            100                 105                 110         
Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
        115                 120                 125             
Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
    130                 135                 140                 
Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
145                 150                 155                 160 
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                165                 170                 175     
Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
            180                 185                 190         
Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
        195                 200                 205             
Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
    210                 215                 220 


<210> 6979
<211> 123
<212> PRT
<213> Homo sapiens

<400> 6979
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val
 1               5                  10                  15      
Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
            20                  25                  30          
Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu
        35                  40                  45              
Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
    50                  55                  60                  
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
65                  70                  75                  80  
Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                85                  90                  95      
Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
            100                 105                 110         
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        115                 120             


<210> 6980
<211> 136
<212> PRT
<213> Homo sapiens

<400> 6980
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val
 1               5                  10                  15      
Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
            20                  25                  30          
Asp Asn Ala Val Asn Leu Ser Tyr Asn Glu Lys Ser Asn Gly Thr Ile
        35                  40                  45              
Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
    50                  55                  60                  
Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
65                  70                  75                  80  
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                85                  90                  95      
Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
            100                 105                 110         
Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
        115                 120                 125             
Arg Asp Phe Ala Ala Tyr Arg Ser
    130                 135     


<210> 6981
<211> 393
<212> PRT
<213> Homo sapiens

<400> 6981
Met Val Ser Arg Ser Leu Val Gly Ile Leu Met Met Ala Asn Val Phe
 1               5                  10                  15      
Ile Tyr Phe Ile Met Glu Val Ser Lys Ser Ser Ser Gln Glu Lys Asn
            20                  25                  30          
Gly Lys Gly Glu Val Ile Ile Pro Lys Glu Lys Phe Trp Lys Ile Ser
        35                  40                  45              
Thr Pro Pro Glu Ala Tyr Trp Asn Arg Glu Gln Glu Lys Leu Asn Arg
    50                  55                  60                  
Gln Tyr Asn Pro Ile Leu Ser Met Leu Thr Asn Gln Thr Gly Glu Ala
65                  70                  75                  80  
Gly Arg Leu Ser Asn Ile Ser His Leu Asn Tyr Cys Glu Pro Asp Leu
                85                  90                  95      
Arg Val Thr Ser Val Val Thr Gly Phe Asn Asn Leu Pro Asp Arg Phe
            100                 105                 110         
Lys Asp Phe Leu Leu Tyr Leu Arg Cys Arg Asn Tyr Ser Leu Leu Ile
        115                 120                 125             
Asp Gln Pro Asp Lys Cys Ala Lys Lys Pro Phe Leu Leu Leu Ala Ile
    130                 135                 140                 
Lys Ser Leu Thr Pro His Phe Ala Arg Arg Gln Ala Ile Arg Glu Ser
145                 150                 155                 160 
Trp Gly Gln Glu Ser Asn Ala Gly Asn Gln Thr Val Val Arg Val Phe
                165                 170                 175     
Leu Leu Gly Gln Thr Pro Pro Glu Asp Asn His Pro Asp Leu Ser Asp
            180                 185                 190         
Met Leu Lys Phe Glu Ser Glu Lys His Gln Asp Ile Leu Met Trp Asn
        195                 200                 205             
Tyr Arg Asp Thr Phe Phe Asn Leu Ser Leu Lys Glu Val Leu Phe Leu
    210                 215                 220                 
Arg Trp Val Ser Thr Ser Cys Pro Asp Thr Glu Phe Val Phe Lys Gly
225                 230                 235                 240 
Asp Asp Asp Val Phe Val Asn Thr His His Ile Leu Asn Tyr Leu Asn
                245                 250                 255     
Ser Leu Ser Lys Thr Lys Ala Lys Asp Leu Phe Ile Gly Asp Val Ile
            260                 265                 270         
His Asn Ala Gly Pro His Arg Asp Lys Lys Leu Lys Tyr Tyr Ile Pro
        275                 280                 285             
Glu Val Val Tyr Ser Gly Leu Tyr Pro Pro Tyr Ala Gly Gly Gly Gly
    290                 295                 300                 
Phe Leu Tyr Ser Gly His Leu Ala Leu Arg Leu Tyr His Ile Thr Asp
305                 310                 315                 320 
Gln Val His Leu Tyr Pro Ile Asp Asp Val Tyr Thr Gly Met Cys Leu
                325                 330                 335     
Gln Lys Leu Gly Leu Val Pro Glu Lys His Lys Gly Phe Arg Thr Phe
            340                 345                 350         
Asp Ile Glu Glu Lys Asn Lys Asn Asn Ile Cys Ser Tyr Val Asp Leu
        355                 360                 365             
Met Leu Val His Ser Arg Lys Pro Gln Glu Met Ile Asp Ile Trp Ser
    370                 375                 380                 
Gln Leu Gln Ser Ala His Leu Lys Cys
385                 390             


<210> 6982
<211> 397
<212> PRT
<213> Homo sapiens

<400> 6982
Met Ser Val Gly Arg Arg Arg Ile Lys Leu Leu Gly Ile Leu Met Met
 1               5                  10                  15      
Ala Asn Val Phe Ile Tyr Phe Ile Met Glu Val Ser Lys Ser Ser Ser
            20                  25                  30          
Gln Glu Lys Asn Gly Lys Gly Glu Val Ile Ile Pro Lys Glu Lys Phe
        35                  40                  45              
Trp Lys Ile Ser Thr Pro Pro Glu Ala Tyr Trp Asn Arg Glu Gln Glu
    50                  55                  60                  
Lys Leu Asn Arg Gln Tyr Asn Pro Ile Leu Ser Met Leu Thr Asn Gln
65                  70                  75                  80  
Thr Gly Glu Ala Gly Arg Leu Ser Asn Ile Ser His Leu Asn Tyr Cys
                85                  90                  95      
Glu Pro Asp Leu Arg Val Thr Ser Val Val Thr Gly Phe Asn Asn Leu
            100                 105                 110         
Pro Asp Arg Phe Lys Asp Phe Leu Leu Tyr Leu Arg Cys Arg Asn Tyr
        115                 120                 125             
Ser Leu Leu Ile Asp Gln Pro Asp Lys Cys Ala Lys Lys Pro Phe Leu
    130                 135                 140                 
Leu Leu Ala Ile Lys Ser Leu Thr Pro His Phe Ala Arg Arg Gln Ala
145                 150                 155                 160 
Ile Arg Glu Ser Trp Gly Gln Glu Ser Asn Ala Gly Asn Gln Thr Val
                165                 170                 175     
Val Arg Val Phe Leu Leu Gly Gln Thr Pro Pro Glu Asp Asn His Pro
            180                 185                 190         
Asp Leu Ser Asp Met Leu Lys Phe Glu Ser Glu Lys His Gln Asp Ile
        195                 200                 205             
Leu Met Trp Asn Tyr Arg Asp Thr Phe Phe Asn Leu Ser Leu Lys Glu
    210                 215                 220                 
Val Leu Phe Leu Arg Trp Val Ser Thr Ser Cys Pro Asp Thr Glu Phe
225                 230                 235                 240 
Val Phe Lys Gly Asp Asp Asp Val Phe Val Asn Thr His His Ile Leu
                245                 250                 255     
Asn Tyr Leu Asn Ser Leu Ser Lys Thr Lys Ala Lys Asp Leu Phe Ile
            260                 265                 270         
Gly Asp Val Ile His Asn Ala Gly Pro His Arg Asp Lys Lys Leu Lys
        275                 280                 285             
Tyr Tyr Ile Pro Glu Val Val Tyr Ser Gly Leu Tyr Pro Pro Tyr Ala
    290                 295                 300                 
Gly Gly Gly Gly Phe Leu Tyr Ser Gly His Leu Ala Leu Arg Leu Tyr
305                 310                 315                 320 
His Ile Thr Asp Gln Val His Leu Tyr Pro Ile Asp Asp Val Tyr Thr
                325                 330                 335     
Gly Met Cys Leu Gln Lys Leu Gly Leu Val Pro Glu Lys His Lys Gly
            340                 345                 350         
Phe Arg Thr Phe Asp Ile Glu Glu Lys Asn Lys Asn Asn Ile Cys Ser
        355                 360                 365             
Tyr Val Asp Leu Met Leu Val His Ser Arg Lys Pro Gln Glu Met Ile
    370                 375                 380                 
Asp Ile Trp Ser Gln Leu Gln Ser Ala His Leu Lys Cys
385                 390                 395         


<210> 6983
<211> 838
<212> PRT
<213> Homo sapiens

<400> 6983
Met Gln Glu Gln Glu Ile Gly Phe Ile Ser Lys Tyr Asn Glu Gly Leu
 1               5                  10                  15      
Cys Val Asn Thr Asp Pro Val Ser Ile Leu Thr Ser Ile Leu Asp Met
            20                  25                  30          
Ser Leu His Arg Gln Met Gly Ser Asp Arg Asp Leu Gln Ser Ser Ala
        35                  40                  45              
Ser Ser Val Ser Leu Pro Ser Val Lys Lys Ala Pro Lys Lys Arg Arg
    50                  55                  60                  
Ile Ser Ile Gly Ser Leu Phe Arg Arg Lys Lys Asp Asn Lys Arg Lys
65                  70                  75                  80  
Ser Arg Glu Leu Asn Gly Gly Val Asp Gly Ile Ala Ser Ile Glu Ser
                85                  90                  95      
Ile His Ser Glu Met Cys Thr Asp Lys Asn Ser Ile Phe Ser Thr Asn
            100                 105                 110         
Thr Ser Ser Asp Asn Gly Leu Thr Ser Ile Ser Lys Gln Ile Gly Asp
        115                 120                 125             
Phe Ile Glu Cys Pro Leu Cys Leu Leu Arg His Ser Lys Asp Arg Phe
    130                 135                 140                 
Pro Asp Ile Met Thr Cys His His Arg Ser Cys Val Asp Cys Leu Arg
145                 150                 155                 160 
Gln Tyr Leu Arg Ile Glu Ile Ser Glu Ser Arg Val Asn Ile Ser Cys
                165                 170                 175     
Pro Glu Cys Thr Glu Arg Phe Asn Pro His Asp Ile Arg Leu Ile Leu
            180                 185                 190         
Ser Asp Asp Val Leu Met Glu Lys Tyr Glu Glu Phe Met Leu Arg Arg
        195                 200                 205             
Trp Leu Val Ala Asp Pro Asp Cys Arg Trp Cys Pro Ala Pro Asp Cys
    210                 215                 220                 
Gly Tyr Ala Val Ile Ala Phe Gly Cys Ala Ser Cys Pro Lys Leu Thr
225                 230                 235                 240 
Cys Gly Arg Glu Gly Cys Gly Thr Glu Phe Cys Tyr His Cys Lys Gln
                245                 250                 255     
Ile Trp His Pro Asn Gln Thr Cys Asp Ala Ala Arg Gln Glu Arg Ala
            260                 265                 270         
Gln Ser Leu Arg Leu Arg Thr Ile Arg Ser Ser Ser Ile Ser Tyr Ser
        275                 280                 285             
Gln Glu Ser Gly Ala Ala Ala Asp Asp Ile Lys Pro Cys Pro Arg Cys
    290                 295                 300                 
Ala Ala Tyr Ile Ile Lys Met Asn Asp Gly Ser Cys Asn His Met Thr
305                 310                 315                 320 
Cys Ala Val Cys Gly Cys Glu Phe Cys Trp Leu Cys Met Lys Glu Ile
                325                 330                 335     
Ser Asp Leu His Tyr Leu Ser Pro Ser Gly Cys Thr Phe Trp Gly Lys
            340                 345                 350         
Lys Pro Trp Ser Arg Lys Lys Lys Ile Leu Trp Gln Leu Gly Thr Leu
        355                 360                 365             
Val Gly Ala Pro Val Gly Ile Ala Leu Ile Ala Gly Ile Ala Ile Pro
    370                 375                 380                 
Ala Met Ile Ile Gly Ile Pro Val Tyr Val Gly Arg Lys Ile His Asn
385                 390                 395                 400 
Arg Tyr Glu Gly Lys Asp Val Ser Lys His Lys Arg Asn Leu Ala Ile
                405                 410                 415     
Ala Gly Gly Val Thr Leu Ser Val Ile Val Ser Pro Val Val Ala Ala
            420                 425                 430         
Val Thr Val Gly Ile Gly Val Pro Ile Met Leu Ala Tyr Val Tyr Gly
        435                 440                 445             
Val Val Pro Ile Ser Leu Cys Arg Ser Gly Gly Cys Gly Val Ser Ala
    450                 455                 460                 
Gly Asn Gly Lys Gly Val Arg Ile Glu Phe Asp Asp Glu Asn Asp Ile
465                 470                 475                 480 
Asn Val Gly Gly Thr Asn Thr Ala Val Asp Thr Thr Ser Val Ala Glu
                485                 490                 495     
Ala Arg His Asn Pro Ser Ile Gly Glu Gly Ser Val Gly Gly Leu Thr
            500                 505                 510         
Gly Ser Leu Ser Ala Ser Gly Ser His Met Asp Arg Ile Gly Ala Ile
        515                 520                 525             
Arg Asp Asn Leu Ser Glu Thr Ala Ser Thr Met Ala Leu Ala Gly Ala
    530                 535                 540                 
Ser Ile Thr Gly Ser Leu Ser Gly Ser Ala Met Val Asn Cys Phe Asn
545                 550                 555                 560 
Arg Leu Glu Val Gln Ala Asp Val Gln Lys Glu Arg Tyr Ser Leu Ser
                565                 570                 575     
Gly Glu Ser Gly Thr Val Ser Leu Gly Thr Val Ser Asp Asn Ala Ser
            580                 585                 590         
Thr Lys Ala Met Ala Gly Ser Ile Leu Asn Ser Tyr Ile Pro Leu Asp
        595                 600                 605             
Lys Glu Gly Asn Ser Met Glu Val Gln Val Asp Ile Glu Ser Lys Pro
    610                 615                 620                 
Ser Lys Phe Arg His Asn Ser Gly Ser Ser Ser Val Asp Asp Gly Ser
625                 630                 635                 640 
Ala Thr Arg Ser Tyr Ala Gly Gly Ser Ser Ser Gly Leu Pro Glu Gly
                645                 650                 655     
Lys Ser Ser Ala Thr Lys Trp Ser Lys Glu Ala Thr Ala Gly Lys Lys
            660                 665                 670         
Ser Lys Ser Gly Lys Leu Arg Lys Lys Gly Asn Met Lys Ile Asn Glu
        675                 680                 685             
Thr Arg Glu Asp Met Asp Ala Gln Leu Leu Glu Gln Gln Ser Thr Asn
    690                 695                 700                 
Ser Ser Glu Phe Glu Ala Pro Ser Leu Ser Asp Ser Met Pro Ser Val
705                 710                 715                 720 
Ala Asp Ser His Ser Ser His Phe Ser Glu Phe Ser Cys Ser Asp Leu
                725                 730                 735     
Glu Ser Met Lys Thr Ser Cys Ser His Gly Ser Ser Asp Tyr His Thr
            740                 745                 750         
Arg Phe Ala Thr Val Asn Ile Leu Pro Glu Val Glu Asn Asp Arg Leu
        755                 760                 765             
Glu Asn Ser Pro His Gln Cys Ser Ile Ser Val Val Thr Gln Thr Ala
    770                 775                 780                 
Ser Cys Ser Glu Val Ser Gln Leu Asn His Ile Ala Glu Glu His Gly
785                 790                 795                 800 
Asn Asn Gly Ile Lys Pro Asn Val Asp Leu Tyr Phe Gly Asp Ala Leu
                805                 810                 815     
Lys Glu Thr Asn Asn Asn His Ser His Gln Thr Met Glu Leu Lys Val
            820                 825                 830         
Ala Ile Gln Thr Glu Ile
        835             


<210> 6984
<211> 1359
<212> PRT
<213> Homo sapiens

<400> 6984
Met Ala Glu Ala Gly Leu Arg Gly Trp Leu Leu Trp Ala Leu Leu Leu
 1               5                  10                  15      
Arg Leu Ala Gln Ser Glu Pro Tyr Thr Thr Ile His Gln Pro Gly Tyr
            20                  25                  30          
Cys Ala Phe Tyr Asp Glu Cys Gly Lys Asn Pro Glu Leu Ser Gly Ser
        35                  40                  45              
Leu Met Thr Leu Ser Asn Val Ser Cys Leu Ser Asn Thr Pro Ala Arg
    50                  55                  60                  
Lys Ile Thr Gly Asp His Leu Ile Leu Leu Gln Lys Ile Cys Pro Arg
65                  70                  75                  80  
Leu Tyr Thr Gly Pro Asn Thr Gln Ala Cys Cys Ser Ala Lys Gln Leu
                85                  90                  95      
Val Ser Leu Glu Ala Ser Leu Ser Ile Thr Lys Ala Leu Leu Thr Arg
            100                 105                 110         
Cys Pro Ala Cys Ser Asp Asn Phe Val Asn Leu His Cys His Asn Thr
        115                 120                 125             
Cys Ser Pro Asn Gln Ser Leu Phe Ile Asn Val Thr Arg Val Ala Gln
    130                 135                 140                 
Leu Gly Ala Gly Gln Leu Pro Ala Val Val Ala Tyr Glu Ala Phe Tyr
145                 150                 155                 160 
Gln His Ser Phe Ala Glu Gln Ser Tyr Asp Ser Cys Ser Arg Val Arg
                165                 170                 175     
Val Pro Ala Ala Ala Thr Leu Ala Val Gly Thr Met Cys Gly Val Tyr
            180                 185                 190         
Gly Ser Ala Leu Cys Asn Ala Gln Arg Trp Leu Asn Phe Gln Gly Asp
        195                 200                 205             
Thr Gly Asn Gly Leu Ala Pro Leu Asp Ile Thr Phe His Leu Leu Glu
    210                 215                 220                 
Pro Gly Gln Ala Val Gly Ser Gly Ile Gln Pro Leu Asn Glu Gly Val
225                 230                 235                 240 
Ala Arg Cys Asn Glu Ser Gln Gly Asp Asp Val Ala Thr Cys Ser Cys
                245                 250                 255     
Gln Asp Cys Ala Ala Ser Cys Pro Ala Ile Ala Arg Pro Gln Ala Leu
            260                 265                 270         
Asp Ser Thr Phe Tyr Leu Gly Gln Met Pro Gly Ser Leu Val Leu Ile
        275                 280                 285             
Ile Ile Leu Cys Ser Val Phe Ala Val Val Thr Ile Leu Leu Val Gly
    290                 295                 300                 
Phe Arg Val Ala Pro Ala Arg Asp Lys Ser Lys Met Val Asp Pro Lys
305                 310                 315                 320 
Lys Gly Thr Ser Leu Ser Asp Lys Leu Ser Phe Ser Thr His Thr Leu
                325                 330                 335     
Leu Gly Gln Phe Phe Gln Gly Trp Gly Thr Trp Val Ala Ser Trp Pro
            340                 345                 350         
Leu Thr Ile Leu Val Leu Ser Val Ile Pro Val Val Ala Leu Ala Ala
        355                 360                 365             
Gly Leu Val Phe Thr Glu Leu Thr Thr Asp Pro Val Glu Leu Trp Ser
    370                 375                 380                 
Ala Pro Asn Ser Gln Ala Arg Ser Glu Lys Ala Phe His Asp Gln His
385                 390                 395                 400 
Phe Gly Pro Phe Phe Arg Thr Asn Gln Val Ile Leu Thr Ala Pro Asn
                405                 410                 415     
Arg Ser Ser Tyr Arg Tyr Asp Ser Leu Leu Leu Gly Pro Lys Asn Phe
            420                 425                 430         
Ser Gly Ile Leu Asp Leu Asp Leu Leu Leu Glu Leu Leu Glu Leu Gln
        435                 440                 445             
Glu Arg Leu Arg His Leu Gln Val Trp Ser Pro Glu Ala Gln Arg Asn
    450                 455                 460                 
Ile Ser Leu Gln Asp Ile Cys Tyr Ala Pro Leu Asn Pro Asp Asn Thr
465                 470                 475                 480 
Ser Leu Tyr Asp Cys Cys Ile Asn Ser Leu Leu Gln Tyr Phe Gln Asn
                485                 490                 495     
Asn Arg Thr Leu Leu Leu Leu Thr Ala Asn Gln Thr Leu Met Gly Gln
            500                 505                 510         
Thr Ser Gln Val Asp Trp Lys Asp His Phe Leu Tyr Cys Ala Asn Ala
        515                 520                 525             
Pro Leu Thr Phe Lys Asp Gly Thr Ala Leu Ala Leu Ser Cys Met Ala
    530                 535                 540                 
Asp Tyr Gly Ala Pro Val Phe Pro Phe Leu Ala Ile Gly Gly Tyr Lys
545                 550                 555                 560 
Gly Lys Asp Tyr Ser Glu Ala Glu Ala Leu Ile Met Thr Phe Ser Leu
                565                 570                 575     
Asn Asn Tyr Pro Ala Gly Asp Pro Arg Leu Ala Gln Ala Lys Leu Trp
            580                 585                 590         
Glu Glu Ala Phe Leu Glu Glu Met Arg Ala Phe Gln Arg Arg Met Ala
        595                 600                 605             
Gly Met Phe Gln Val Thr Phe Met Ala Glu Arg Ser Leu Glu Asp Glu
    610                 615                 620                 
Ile Asn Arg Thr Thr Ala Glu Asp Leu Pro Ile Phe Ala Thr Ser Tyr
625                 630                 635                 640 
Ile Val Ile Phe Leu Tyr Ile Ser Leu Ala Leu Gly Ser Tyr Ser Ser
                645                 650                 655     
Trp Ser Arg Val Met Val Asp Ser Lys Ala Thr Leu Gly Leu Gly Gly
            660                 665                 670         
Val Ala Val Val Leu Gly Ala Val Met Ala Ala Met Gly Phe Phe Ser
        675                 680                 685             
Tyr Leu Gly Ile Arg Ser Ser Leu Val Ile Leu Gln Val Val Pro Phe
    690                 695                 700                 
Leu Val Leu Ser Val Gly Ala Asp Asn Ile Phe Ile Phe Val Leu Glu
705                 710                 715                 720 
Tyr Gln Arg Leu Pro Arg Arg Pro Gly Glu Pro Arg Glu Val His Ile
                725                 730                 735     
Gly Arg Ala Leu Gly Arg Val Ala Pro Ser Met Leu Leu Cys Ser Leu
            740                 745                 750         
Ser Glu Ala Ile Cys Phe Phe Leu Gly Ala Leu Thr Pro Met Pro Ala
        755                 760                 765             
Val Arg Thr Phe Ala Leu Thr Ser Gly Leu Ala Val Ile Leu Asp Phe
    770                 775                 780                 
Leu Leu Gln Met Ser Ala Phe Val Ala Leu Leu Ser Leu Asp Ser Lys
785                 790                 795                 800 
Arg Gln Glu Ala Ser Arg Leu Asp Val Cys Cys Cys Val Lys Pro Gln
                805                 810                 815     
Glu Leu Pro Pro Pro Gly Gln Gly Glu Gly Leu Leu Leu Gly Phe Phe
            820                 825                 830         
Gln Lys Ala Tyr Ala Pro Phe Leu Leu His Trp Ile Thr Arg Gly Val
        835                 840                 845             
Val Leu Leu Leu Phe Leu Ala Leu Phe Gly Val Ser Leu Tyr Ser Met
    850                 855                 860                 
Cys His Ile Ser Val Gly Leu Asp Gln Glu Leu Ala Leu Pro Lys Asp
865                 870                 875                 880 
Ser Tyr Leu Leu Asp Tyr Phe Leu Phe Leu Asn Arg Tyr Phe Glu Val
                885                 890                 895     
Gly Ala Pro Val Tyr Phe Val Thr Thr Leu Gly Tyr Asn Phe Ser Ser
            900                 905                 910         
Glu Ala Gly Met Asn Ala Ile Cys Ser Ser Ala Gly Cys Asn Asn Phe
        915                 920                 925             
Ser Phe Thr Gln Lys Ile Gln Tyr Ala Thr Glu Phe Pro Glu Gln Ser
    930                 935                 940                 
Tyr Leu Ala Ile Pro Ala Ser Ser Trp Val Asp Asp Phe Ile Asp Trp
945                 950                 955                 960 
Leu Thr Pro Ser Ser Cys Cys Arg Leu Tyr Ile Ser Gly Pro Asn Lys
                965                 970                 975     
Asp Lys Phe Cys Pro Ser Thr Val Asn Ser Leu Asn Cys Leu Lys Asn
            980                 985                 990         
Cys Met Ser Ile Thr Met Gly Ser Val Arg Pro Ser Val Glu Gln Phe
        995                 1000                1005            
His Lys Tyr Leu Pro Trp Phe Leu Asn Asp Arg Pro Asn Ile Lys Cys
    1010                1015                1020                
Pro Lys Gly Gly Leu Ala Ala Tyr Ser Thr Ser Val Asn Leu Thr Ser
1025                1030                1035                1040
Asp Gly Gln Val Leu Asp Thr Val Ala Ile Leu Ser Pro Arg Leu Glu
                1045                1050                1055    
Tyr Ser Gly Thr Ile Ser Ala His Cys Asn Leu Tyr Leu Leu Asp Ser
            1060                1065                1070        
Ala Ser Arg Phe Met Ala Tyr His Lys Pro Leu Lys Asn Ser Gln Asp
        1075                1080                1085            
Tyr Thr Glu Ala Leu Arg Ala Ala Arg Glu Leu Ala Ala Asn Ile Thr
    1090                1095                1100                
Ala Asp Leu Arg Lys Val Pro Gly Thr Asp Pro Ala Phe Glu Val Phe
1105                1110                1115                1120
Pro Tyr Thr Ile Thr Asn Val Phe Tyr Glu Gln Tyr Leu Thr Ile Leu
                1125                1130                1135    
Pro Glu Gly Leu Phe Met Leu Ser Leu Cys Leu Val Pro Thr Phe Ala
            1140                1145                1150        
Val Ser Cys Leu Leu Leu Gly Leu Asp Leu Arg Ser Gly Leu Leu Asn
        1155                1160                1165            
Leu Leu Ser Ile Val Met Ile Leu Val Asp Thr Val Gly Phe Met Ala
    1170                1175                1180                
Leu Trp Gly Ile Ser Tyr Asn Ala Val Ser Leu Ile Asn Leu Val Ser
1185                1190                1195                1200
Ala Val Gly Met Ser Val Glu Phe Val Ser His Ile Thr Arg Ser Phe
                1205                1210                1215    
Ala Ile Ser Thr Lys Pro Thr Trp Leu Glu Arg Ala Lys Glu Ala Thr
            1220                1225                1230        
Ile Ser Met Gly Ser Ala Val Phe Ala Gly Val Ala Met Thr Asn Leu
        1235                1240                1245            
Pro Gly Ile Leu Val Leu Gly Leu Ala Lys Ala Gln Leu Ile Gln Ile
    1250                1255                1260                
Phe Phe Phe Arg Leu Asn Leu Leu Ile Thr Leu Leu Gly Leu Leu His
1265                1270                1275                1280
Gly Leu Val Phe Leu Pro Val Ile Leu Ser Tyr Val Gly Pro Asp Val
                1285                1290                1295    
Asn Pro Ala Leu Ala Leu Glu Gln Lys Arg Ala Glu Glu Ala Val Ala
            1300                1305                1310        
Ala Val Met Val Ala Ser Cys Pro Asn His Pro Ser Arg Val Ser Thr
        1315                1320                1325            
Ala Asp Asn Ile Tyr Val Asn His Ser Phe Glu Gly Ser Ile Lys Gly
    1330                1335                1340                
Ala Gly Ala Ile Ser Asn Phe Leu Pro Asn Asn Gly Arg Gln Phe
1345                1350                1355                


<210> 6985
<211> 273
<212> PRT
<213> Homo sapiens

<400> 6985
Met Thr Phe Asp Asp Leu Lys Ile Gln Thr Val Lys Asp Gln Pro Asp
 1               5                  10                  15      
Glu Lys Ser Asn Gly Lys Lys Ala Lys Gly Leu Gln Phe Leu Tyr Ser
            20                  25                  30          
Pro Trp Trp Cys Leu Ala Ala Ala Thr Leu Gly Val Leu Cys Leu Gly
        35                  40                  45              
Leu Val Val Thr Ile Met Val Leu Gly Met Gln Leu Ser Gln Val Ser
    50                  55                  60                  
Asp Leu Leu Thr Gln Glu Gln Ala Asn Leu Thr His Gln Lys Lys Lys
65                  70                  75                  80  
Leu Glu Gly Gln Ile Ser Ala Arg Gln Gln Ala Glu Glu Ala Ser Gln
                85                  90                  95      
Glu Ser Glu Asn Glu Leu Lys Glu Met Ile Glu Thr Leu Ala Arg Lys
            100                 105                 110         
Leu Asn Glu Lys Ser Lys Glu Gln Met Glu Leu His His Gln Asn Leu
        115                 120                 125             
Asn Leu Gln Glu Thr Leu Lys Arg Val Ala Asn Cys Ser Ala Pro Cys
    130                 135                 140                 
Pro Gln Asp Trp Ile Trp His Gly Glu Asn Cys Tyr Leu Phe Ser Ser
145                 150                 155                 160 
Gly Ser Phe Asn Trp Glu Lys Ser Gln Glu Lys Cys Leu Ser Leu Asp
                165                 170                 175     
Ala Lys Leu Leu Lys Ile Asn Ser Thr Ala Asp Leu Asp Phe Ile Gln
            180                 185                 190         
Gln Ala Ile Ser Tyr Ser Ser Phe Pro Phe Trp Met Gly Leu Ser Arg
        195                 200                 205             
Arg Asn Pro Ser Tyr Pro Trp Leu Trp Glu Asp Gly Ser Pro Leu Met
    210                 215                 220                 
Pro His Leu Phe Arg Val Arg Gly Ala Val Ser Gln Thr Tyr Pro Ser
225                 230                 235                 240 
Gly Thr Cys Ala Tyr Ile Gln Arg Gly Ala Val Tyr Ala Glu Asn Cys
                245                 250                 255     
Ile Leu Ala Ala Phe Ser Ile Cys Gln Lys Lys Ala Asn Leu Arg Ala
            260                 265                 270         
Gln
    


<210> 6986
<211> 329
<212> PRT
<213> Homo sapiens

<400> 6986
Met Met Gly His Gln Asn His Thr Phe Ser Ser Asp Phe Ile Leu Leu
 1               5                  10                  15      
Gly Leu Phe Ser Ser Ser Pro Thr Ser Val Val Phe Phe Leu Val Leu
            20                  25                  30          
Phe Val Ile Phe Ile Met Ser Val Thr Glu Asn Thr Leu Met Ile Leu
        35                  40                  45              
Leu Ile Arg Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu
    50                  55                  60                  
Ser His Leu Ser Leu Met Asp Ile Leu His Val Ser Asn Ile Val Pro
65                  70                  75                  80  
Lys Met Val Thr Asn Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala
                85                  90                  95      
Gly Cys Gly Phe Gln Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu
            100                 105                 110         
Cys Leu Leu Leu Ala Ala Met Ser Cys Asp Arg Tyr Val Ala Ile Cys
        115                 120                 125             
His Pro Leu Arg Tyr Pro Ile Leu Met Lys Glu Tyr Ala Ser Ala Leu
    130                 135                 140                 
Met Ala Gly Gly Ser Trp Leu Ile Gly Val Phe Asn Ser Thr Val His
145                 150                 155                 160 
Thr Ala Tyr Ala Leu Gln Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp
                165                 170                 175     
His Phe Phe Cys Glu Val Pro Ala Met Leu Lys Leu Ser Cys Ala Asp
            180                 185                 190         
Thr Thr Arg Tyr Glu Arg Gly Val Cys Val Ser Ala Val Ile Phe Leu
        195                 200                 205             
Leu Ile Pro Phe Ser Leu Ile Ser Ala Ser Tyr Gly Gln Ile Ile Leu
    210                 215                 220                 
Thr Val Leu Gln Met Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser
225                 230                 235                 240 
Thr Cys Ser Phe His Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe
                245                 250                 255     
Ile Phe Thr Tyr Met Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp
            260                 265                 270         
Lys Phe Leu Ala Ile Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro
        275                 280                 285             
Phe Ile Tyr Ser Phe Arg Asn Lys Asp Val Leu Ala Val Met Lys Asn
    290                 295                 300                 
Met Leu Lys Ser Asn Phe Leu His Lys Lys Met Asn Arg Lys Ile Pro
305                 310                 315                 320 
Glu Cys Val Phe Cys Leu Phe Leu Cys
                325                 


<210> 6987
<211> 4031
<212> PRT
<213> Homo sapiens

<400> 6987
Gly Gln Arg Val Leu Ala Ala Met Ser Ser Glu Gln Asp Lys Ser Ala
 1               5                  10                  15      
Ser Lys Glu Lys Ser Lys Lys Pro Val Arg Phe Leu Pro Gln Leu Ser
            20                  25                  30          
Met Glu Lys Leu Ala Ser Lys Glu Lys Phe Lys Ala Pro Ala Arg Ala
        35                  40                  45              
Leu Pro Gln Leu Ser Met Val Ser Thr Lys Pro His Trp Gln Gln Ala
    50                  55                  60                  
Ala Pro Ser Phe His Leu Ser Val Lys Gln Asp Asp Glu Ser Pro Glu
65                  70                  75                  80  
Pro Phe Ser Val Lys Asn Glu Gln Ser His Ala Glu Tyr Met Glu Arg
                85                  90                  95      
Phe Gly Lys Lys Gly Lys Leu Pro His Gln Val Asp Asp Ser Tyr Val
            100                 105                 110         
Gly Pro Ser Thr Ser Lys Ser Lys Gly Lys Ser Pro His Lys Glu Arg
        115                 120                 125             
Glu Asn Phe Arg Ser Thr Leu Val Asn Val Ile Met Gln Gln Asp Ala
    130                 135                 140                 
Asp Leu Asp Ser Ala Val Pro Asp Gly Ser Thr Ile Pro Lys Pro Thr
145                 150                 155                 160 
Ala Ser Ala Ile Glu Lys Asp Ile Leu Arg Tyr Tyr Tyr Tyr Ile His
                165                 170                 175     
His Gly Ile Asp Thr Asp His Val Ala Pro Met Glu Asp Ser Trp Leu
            180                 185                 190         
Glu His Val Leu Asp Leu Val Pro Gln His Leu Lys Val Phe Thr Asp
        195                 200                 205             
Ser Ile Val Thr Leu Ser Asp Glu Met Arg Glu Asp Tyr Leu Leu Ser
    210                 215                 220                 
Val Arg Lys Ser Ile Val Asp Phe Val Leu Lys Asp Pro Arg Glu Lys
225                 230                 235                 240 
Gly Asp Asp Lys Lys Thr Asp Glu Leu Pro Ala His Arg Ala Glu Met
                245                 250                 255     
Glu Ile Leu Pro Lys Pro Trp Arg Lys Ser Phe Leu Ala Ala Ser Ser
            260                 265                 270         
Tyr Ile Arg Asp His Leu Asn Ala Met Asn Pro Thr Met Leu Ala Val
        275                 280                 285             
Leu Asp Leu Trp His Thr Asn Phe Lys Lys Leu Arg Leu Val Asp Ile
    290                 295                 300                 
Lys Glu Phe His Asn Cys Gln Asp Ala Leu Glu Leu Ser Ser Phe Gln
305                 310                 315                 320 
Asn Ile Ile Met Arg His Met Asp Ser Ala Lys Glu Thr Leu Leu Lys
                325                 330                 335     
Met Trp Phe Pro Glu Val Gln Asn Ile Tyr Tyr Gln Gly Asn Lys Lys
            340                 345                 350         
Lys Gln Leu Pro Thr Gly Asp Ser Ser Ala Lys Leu Glu Ser Phe Phe
        355                 360                 365             
Asn Cys Ala Ala Ala Leu Met Thr Leu Gln Leu Gln Asp Leu Thr Leu
    370                 375                 380                 
Val Ser Met Gln Asp Phe Thr Asp Leu Ile Ala Gln Pro Pro Asp Ser
385                 390                 395                 400 
Val Arg Ala Phe Glu His Pro Gly Phe Ile Met Arg Leu Ile Leu Asp
                405                 410                 415     
Asn Asp Thr Ile Lys Phe Glu Pro Glu Leu Ser Asp Tyr Ile Asp Ile
            420                 425                 430         
Phe Leu Asn Val Tyr Asp Val Met Ile Lys Ala Val Ser Phe Val Pro
        435                 440                 445             
Arg Val Glu Thr Lys Leu Tyr Ser Lys Trp Glu Ser Lys Ser Lys Pro
    450                 455                 460                 
Thr Thr Leu Lys Pro Ile Ile Leu Asn Glu Ile Val Asp Ala His Lys
465                 470                 475                 480 
Glu Lys Ile Lys Glu Val Ile Met Lys Glu Ser Val Ala Pro Thr Glu
                485                 490                 495     
His Leu Arg Leu Tyr Asp Lys Tyr Asp Phe Leu Ile Thr Arg Lys Ala
            500                 505                 510         
Glu Arg Asp Val Asp Asn Phe Leu Ala Glu Asn His Ser Tyr Glu Lys
        515                 520                 525             
Ile Ile Asp Glu Ile Cys Lys Tyr Gln Lys Leu Ile Glu Glu Ile Gln
    530                 535                 540                 
Tyr Thr Ser Ile Lys Thr Ile Cys Leu Gly Met Phe Glu Met His Cys
545                 550                 555                 560 
Glu Glu Leu Ile Arg Ala Leu Val Lys Arg Ala Asp Ile Ile Cys Gly
                565                 570                 575     
Lys Leu Leu Ala Lys Met Phe Arg Asp His Gln Glu Val Asn Thr Arg
            580                 585                 590         
Leu Cys Asp Glu Phe Glu Arg Ile Ala Glu Lys Ala Leu Ser Thr Pro
        595                 600                 605             
Pro Asn Thr Ala Glu Leu Met Glu Met Lys Ala Tyr Ile Gln Lys Val
    610                 615                 620                 
Glu Val Thr Asp Met Ile Glu Leu Glu Gln Arg Leu Val Asp Ser Lys
625                 630                 635                 640 
Asn Cys Leu Ala Phe Leu Ile Glu Tyr Val Asn Phe Ser Pro Ala Asp
                645                 650                 655     
Met Arg Leu Asn Asn Ser Val Phe Gln Trp Tyr Gly Arg Met Gly Glu
            660                 665                 670         
Ile Phe Glu Glu His Arg Lys Ile Ile Lys Glu Lys Ile Glu Gln Tyr
        675                 680                 685             
Gln Glu Gly Leu Lys Leu Arg Cys Glu Arg Phe Val Glu Glu Leu Glu
    690                 695                 700                 
Ser Tyr Ala Lys Gln Ser Glu Glu Phe Tyr Ser Phe Gly Asp Leu Gln
705                 710                 715                 720 
Asp Val Gln Arg Tyr Leu Lys Lys Ala Gln Ile Leu Asn Gly Lys Leu
                725                 730                 735     
Asp Leu Ala Ala Asp Lys Ile Glu Gln Phe Asn Ala Glu Glu Glu Ala
            740                 745                 750         
Phe Gly Trp Leu Pro Ser Val Tyr Pro Gln Arg Lys Lys Ile Gln Asp
        755                 760                 765             
Gly Leu Asn Pro Tyr Leu Arg Leu Tyr Glu Thr Ala Val Glu Phe Ser
    770                 775                 780                 
Ser Asn Tyr Arg Ala Trp Thr Glu Gly Pro Tyr His Lys Val Asn Pro
785                 790                 795                 800 
Asp Gln Val Glu Ala Asp Ile Gly Asn Tyr Trp Arg Gly Leu Tyr Lys
                805                 810                 815     
Leu Glu Lys Thr Phe His Asp Ser Pro Tyr Ala Leu Ala Met Thr Lys
            820                 825                 830         
Lys Val Arg Ser Lys Val Glu Asp Phe Lys Gln His Ile Pro Leu Ile
        835                 840                 845             
Gln Val Ile Cys Asn Pro Gly Leu Arg Pro Arg His Trp Glu Ala Met
    850                 855                 860                 
Ser Ala Ile Val Gly Tyr Pro Leu Gln Pro Ser Asp Asp Ser Thr Val
865                 870                 875                 880 
Ser Ser Phe Leu Asp Met Asn Leu Glu Pro Tyr Ile Asp Arg Phe Glu
                885                 890                 895     
Gly Ile Ser Glu Ala Ala Ser Lys Glu Tyr Ser Leu Glu Lys Ala Met
            900                 905                 910         
Glu Lys Met Ile Thr Glu Trp Asp Ala Val Glu Phe Val Ile His Ser
        915                 920                 925             
Tyr Arg Glu Thr Gly Thr Phe Ile Leu Ala Ser Val Asp Glu Ile Gln
    930                 935                 940                 
Met Leu Leu Asp Asp His Ile Ile Lys Thr Gln Thr Met Arg Gly Ser
945                 950                 955                 960 
Pro Phe Ile Lys Pro Tyr Glu Lys Gln Met Arg Glu Trp Glu Gly Lys
                965                 970                 975     
Leu Leu Leu Leu Gln Glu Ile Leu Asp Glu Trp Leu Lys Val Gln Ala
            980                 985                 990         
Thr Trp Leu Tyr Leu Glu Pro Ile Phe Ser Ser Pro Asp Ile Met Ser
        995                 1000                1005            
Gln Met Pro Glu Glu Gly Arg Arg Phe Thr Ala Val Asp Lys Thr Trp
    1010                1015                1020                
Arg Asp Thr Met Arg Ser Val Met Gln Asp Lys His Val Leu Thr Val
1025                1030                1035                1040
Val Thr Ile Asp Arg Met Leu Glu Arg Leu Lys Lys Ser Asn Glu Leu
                1045                1050                1055    
Leu Glu Leu Ile Leu Lys Gly Leu Asn Glu Tyr Leu Glu Lys Lys Arg
            1060                1065                1070        
Leu Phe Phe Pro Arg Phe Phe Phe Leu Ser Asn Asp Glu Leu Leu Glu
        1075                1080                1085            
Ile Leu Ser Glu Thr Lys Asp Pro Thr Arg Val Gln Pro His Leu Lys
    1090                1095                1100                
Lys Cys Phe Glu Gly Ile Ala Lys Val Glu Phe Thr Glu Thr Leu Asp
1105                1110                1115                1120
Ile Thr His Met Lys Ser Ser Glu Gly Glu Val Val Glu Leu Ile Glu
                1125                1130                1135    
Ile Ile Ser Thr Ala Lys Ala Arg Gly Gln Val Glu Lys Trp Leu Val
            1140                1145                1150        
Glu Leu Glu Arg Val Met Ile Asn Ser Ile His Lys Val Thr Gly Asp
        1155                1160                1165            
Ala Thr Phe Ala Tyr Thr Lys Tyr Glu Arg Ile Asn Trp Val Arg Asp
    1170                1175                1180                
Trp Pro Gly Gln Thr Val Leu Cys Val Ser Gln Ile Phe Trp Thr Lys
1185                1190                1195                1200
Glu Val Gln Thr Ala Ile Pro Met Gly Ile Lys Ala Leu Glu Gln Tyr
                1205                1210                1215    
Leu Lys Thr Cys Asn Arg Gln Ile Asp Asp Ile Val Thr Leu Val Arg
            1220                1225                1230        
Gly Lys Leu Ser Met Gln Asn Arg Val Thr Leu Gly Ala Leu Val Val
        1235                1240                1245            
Leu Asp Val His Ala Arg Asp Val Leu Ser Ser Leu Val Lys Lys Asn
    1250                1255                1260                
Ile Ser Asp Asp Ser Asp Phe Glu Trp Leu Ser Gln Leu Arg Tyr Tyr
1265                1270                1275                1280
Trp Gln Glu Asn His Leu Glu Thr Lys Met Ile Asn Ala Gly Leu Arg
                1285                1290                1295    
Tyr Gly Tyr Glu Tyr Leu Gly Asn Ser Pro Arg Leu Val Ile Thr Pro
            1300                1305                1310        
Leu Thr Asp Arg Cys Tyr Arg Thr Leu Phe Gly Ala Leu His Leu His
        1315                1320                1325            
Leu Gly Gly Ala Pro Glu Gly Pro Ala Gly Thr Gly Lys Thr Glu Thr
    1330                1335                1340                
Thr Lys Asp Leu Ala Lys Ala Val Ala Lys Gln Cys Val Val Phe Asn
1345                1350                1355                1360
Cys Ser Asp Gly Leu Asp Tyr Leu Ala Leu Gly Lys Phe Phe Lys Gly
                1365                1370                1375    
Leu Leu Ser Cys Gly Ala Trp Ala Cys Phe Asp Glu Phe Asn Arg Ile
            1380                1385                1390        
Asp Leu Glu Val Leu Ser Val Val Ala Gln Gln Ile Leu Thr Ile Gln
        1395                1400                1405            
Arg Gly Ile Asn Ala Gly Ala Asp Ile Leu Met Phe Glu Gly Thr Glu
    1410                1415                1420                
Leu Lys Leu Asp Pro Thr Cys Ala Val Phe Ile Thr Met Asn Pro Gly
1425                1430                1435                1440
Tyr Ala Gly Arg Ser Glu Leu Pro Asp Asn Leu Lys Ala Leu Phe Arg
                1445                1450                1455    
Thr Val Ala Met Met Val Pro Asp Tyr Ala Met Ile Ala Glu Ile Val
            1460                1465                1470        
Leu Tyr Ser Cys Gly Phe Val Thr Ala Arg Pro Leu Ser Val Lys Ile
        1475                1480                1485            
Val Ala Thr Tyr Arg Leu Cys Ser Glu Gln Leu Ser Ser Gln His His
    1490                1495                1500                
Tyr Asp Tyr Gly Met Arg Ala Val Lys Ser Val Leu Thr Ala Ala Gly
1505                1510                1515                1520
Asn Leu Lys Leu Lys Tyr Pro Asn Glu Asn Glu Glu Ile Leu Leu Leu
                1525                1530                1535    
Arg Ser Ile Ile Asp Val Asn Leu Pro Lys Phe Leu Ser His Asp Leu
            1540                1545                1550        
Pro Leu Phe Glu Gly Ile Thr Ser Asp Leu Phe Pro Gly Val Lys Leu
        1555                1560                1565            
Pro Lys Pro Asp Tyr Asn Asp Leu Leu Ala Ala Ile Lys Asp Asn Cys
    1570                1575                1580                
Ala Ser Met Asn Leu Gln Met Thr Ala Phe Phe Ser Glu Lys Ile Leu
1585                1590                1595                1600
Gln Val Tyr Glu Met Met Ile Val Arg His Gly Phe Met Ile Val Gly
                1605                1610                1615    
Glu Pro Phe Gly Gly Lys Thr Ser Ala Tyr Arg Val Leu Ala Gly Ala
            1620                1625                1630        
Leu Asn Asp Ile Cys Glu Lys Gly Leu Met Glu Glu Asn Lys Val Gln
        1635                1640                1645            
Ile Thr Val Leu Asn Pro Lys Ser Val Thr Met Gly Gln Leu Tyr Gly
    1650                1655                1660                
Gln Phe Asp Ser Val Ser His Glu Trp Ser Asp Gly Val Leu Ala Val
1665                1670                1675                1680
Ser Phe Arg Ala Phe Ala Ser Ser Val Thr Pro Asp Arg Lys Trp Leu
                1685                1690                1695    
Ile Phe Asp Gly Pro Val Asp Ala Val Trp Ile Glu Asn Met Asn Thr
            1700                1705                1710        
Val Leu Asp Asp Asn Lys Lys Leu Cys Leu Met Ser Gly Glu Ile Ile
        1715                1720                1725            
Gln Met Ser Pro Gln Met Asn Leu Ile Phe Glu Pro Met Asp Leu Glu
    1730                1735                1740                
Val Ala Ser Pro Ala Thr Val Ser Arg Cys Gly Met Ile Tyr Met Glu
1745                1750                1755                1760
Pro His Met Leu Gly Trp Arg Pro Leu Met Leu Ser Trp Val Asn Leu
                1765                1770                1775    
Leu Pro Ala Ser Val Ser Val Ile Gln Lys Glu Phe Ile Met Gly Leu
            1780                1785                1790        
Phe Asp Arg Met Val Pro Val Ser Val Glu Phe Ile Arg Lys His Thr
        1795                1800                1805            
Lys Glu Leu Ser Pro Thr Ser Asp Thr Asn Leu Val Arg Ser Leu Met
    1810                1815                1820                
Asn Leu Ile Asp Cys Phe Met Asp Asp Phe Ala Asp Glu Val Lys Leu
1825                1830                1835                1840
Lys Glu Arg Asn Asp Arg Glu Thr Tyr Ser Leu Leu Glu Gly Ile Phe
                1845                1850                1855    
Leu Phe Ser Leu Ile Trp Ser Val Gly Ala Ser Cys Thr Asp Asp Asp
            1860                1865                1870        
Arg Leu Lys Phe Asn Lys Ile Leu Arg Glu Leu Met Glu Ser Pro Ile
        1875                1880                1885            
Ser Asp Arg Thr Arg Asn Thr Phe Lys Leu Gln Ser Gly Thr Glu Gln
    1890                1895                1900                
Thr Ser Ser Lys Ala Leu Thr Val Pro Phe Pro Glu Lys Gly Thr Ile
1905                1910                1915                1920
Tyr Asp Tyr Gln Phe Val Thr Glu Gly Ile Gly Lys Trp Glu Pro Trp
                1925                1930                1935    
Ile Lys Lys Leu Lys Glu Ala Pro Pro Ile Pro Lys Asp Val Met Phe
            1940                1945                1950        
Asn Glu Ile Ile Val Pro Thr Leu Asp Thr Ile Arg Tyr Ser Ala Leu
        1955                1960                1965            
Met Glu Leu Leu Thr Thr His Gln Lys Pro Ser Ile Phe Val Gly Pro
    1970                1975                1980                
Thr Gly Thr Gly Lys Ser Val Tyr Ile Thr Asn Phe Leu Leu Asn Gln
1985                1990                1995                2000
Leu Asn Lys Glu Ile Tyr Lys Pro Leu Leu Ile Asn Phe Ser Ala Gln
                2005                2010                2015    
Thr Thr Ala Ala Gln Thr Gln Asn Ile Val Met Ser Lys Leu Asp Lys
            2020                2025                2030        
Arg Arg Lys Gly Val Phe Gly Pro Pro Leu Gly Lys Arg Met Val Val
        2035                2040                2045            
Phe Val Asp Asp Val Asn Met Pro Ala Arg Glu Val Tyr Gly Ala Gln
    2050                2055                2060                
Pro Pro Ile Glu Leu Leu Arg Gln Trp Leu Asp His Trp Asn Trp Tyr
2065                2070                2075                2080
Asp Leu Lys Asp Cys Ser Met Ile Lys Leu Val Asp Ile Gln Ile Met
                2085                2090                2095    
Cys Ala Met Gly Pro Pro Gly Gly Gly Arg Asn Pro Val Thr Pro Arg
            2100                2105                2110        
Tyr Met Arg His Phe Asn Ile Ile Thr Ile Asn Glu Phe Ser Asp Lys
        2115                2120                2125            
Ser Met Tyr Thr Ile Phe Ser Arg Ile Leu Thr Trp His Leu Glu Ile
    2130                2135                2140                
Cys Tyr Lys Phe Pro Asp Glu Phe Leu Asp Leu Thr Thr Gln Ile Val
2145                2150                2155                2160
Asn Gly Thr Met Thr Leu Tyr Lys Glu Ala Met Lys Asn Leu Leu Pro
                2165                2170                2175    
Thr Pro Ala Lys Ser His Tyr Leu Phe Asn Leu Arg Asp Phe Ser Arg
            2180                2185                2190        
Val Ile Gln Gly Val Cys Leu Ser Arg Pro Glu Thr Thr Glu Thr Thr
        2195                2200                2205            
Glu Val Ile Lys Arg Leu Trp Val His Glu Val Leu Arg Val Tyr Tyr
    2210                2215                2220                
Asp Arg Leu Leu Asp Asn Thr Asp Arg Ser Trp Leu Ile Asn Tyr Ile
2225                2230                2235                2240
Gln Glu Ile Leu Arg Asn Tyr Met Tyr Glu Asp Phe His Glu Leu Phe
                2245                2250                2255    
Gln Arg Leu Asp Phe Asp Asn Asp Gly Met Val Glu Ala Asp Asp Leu
            2260                2265                2270        
Arg Ser Leu Met Phe Cys Asp Phe His Asp Pro Lys Arg Glu Asp Thr
        2275                2280                2285            
Asn Tyr Arg Glu Ile Ala Asp Val Asp Asn Leu Arg Met Ile Val Glu
    2290                2295                2300                
Ile His Leu Glu Glu Tyr Asn Asn Ile Ser Lys Lys Pro Met Asn Leu
2305                2310                2315                2320
Val Leu Phe Arg Phe Ala Ile Glu His Ile Ser Arg Ile Ser Arg Ile
                2325                2330                2335    
Leu Lys Gln Pro Arg Ser His Ala Leu Leu Val Gly Val Gly Gly Ser
            2340                2345                2350        
Gly Arg Gln Ser Val Thr Arg Leu Ala Ala His Met Ala Asp Tyr Ser
        2355                2360                2365            
Val Phe Gln Val Glu Ile Ser Lys Gly Tyr Asp Thr Thr Glu Trp His
    2370                2375                2380                
Glu Asp Leu Lys Val Ile Leu Arg Lys Cys Ala Glu Gly Glu Met Gln
2385                2390                2395                2400
Gly Val Phe Leu Phe Thr Asp Thr Gln Ile Lys Glu Glu Ser Phe Leu
                2405                2410                2415    
Glu Asp Val Ser Asn Leu Leu Asn Ala Gly Glu Ile Pro Asn Leu Phe
            2420                2425                2430        
Ala Leu Asp Glu Lys Gln Glu Ile Cys Asp Lys Met Arg Gln Leu Asp
        2435                2440                2445            
Arg Gln Arg Asp Lys Thr Lys Gln Thr Asp Gly Ser Pro Ile Ala Leu
    2450                2455                2460                
Phe Asn Met Phe Ile Asp His Cys Arg Ser Gln Leu His Val Val Leu
2465                2470                2475                2480
Ala Met Ser Pro Ile Gly Asp Ala Phe Arg Asn Arg Leu Arg Lys Phe
                2485                2490                2495    
Pro Ala Leu Val Asn Cys Cys Thr Ile Asp Trp Phe Gln Ser Trp Pro
            2500                2505                2510        
Glu Asp Ala Leu Gln Ala Val Ala Ser Arg Phe Leu Glu Glu Ile Glu
        2515                2520                2525            
Met Ser Glu Glu Ile Arg Asp Gly Cys Ile Asp Met Cys Lys Ser Phe
    2530                2535                2540                
His Thr Ser Thr Ile Asp Leu Ser Lys Ser Phe Phe Val Glu Leu Gln
2545                2550                2555                2560
Arg Tyr Asn Tyr Val Thr Pro Thr Ser Tyr Leu Glu Leu Ile Ser Thr
                2565                2570                2575    
Phe Lys Leu Leu Leu Glu Lys Lys Arg Ser Glu Val Met Lys Met Lys
            2580                2585                2590        
Lys Arg Tyr Glu Val Gly Leu Glu Lys Leu Asp Ser Ala Ser Ser Gln
        2595                2600                2605            
Val Ala Thr Met Gln Met Glu Leu Glu Ala Leu His Pro Gln Leu Lys
    2610                2615                2620                
Val Ala Ser Lys Glu Val Asp Glu Met Met Ile Met Ile Glu Lys Glu
2625                2630                2635                2640
Ser Val Glu Val Ala Lys Thr Glu Lys Ile Val Lys Ala Asp Glu Thr
                2645                2650                2655    
Ile Ala Asn Glu Gln Ala Met Ala Ser Lys Ala Ile Lys Asp Glu Cys
            2660                2665                2670        
Asp Ala Asp Leu Ala Gly Ala Leu Pro Ile Leu Glu Ser Ala Leu Ala
        2675                2680                2685            
Ala Leu Asp Thr Leu Thr Ala Gln Asp Ile Thr Val Val Lys Ser Met
    2690                2695                2700                
Lys Ser Pro Pro Ala Gly Val Lys Leu Val Met Glu Ala Ile Cys Ile
2705                2710                2715                2720
Leu Lys Gly Ile Lys Ala Asp Lys Ile Pro Asp Pro Thr Gly Ser Gly
                2725                2730                2735    
Lys Lys Ile Glu Asp Phe Trp Gly Pro Ala Lys Arg Leu Leu Gly Asp
            2740                2745                2750        
Met Arg Phe Leu Gln Ser Leu His Glu Tyr Asp Lys Asp Asn Ile Pro
        2755                2760                2765            
Pro Ala Tyr Met Asn Ile Ile Arg Lys Asn Tyr Ile Pro Asn Pro Asp
    2770                2775                2780                
Phe Val Pro Glu Lys Ile Arg Asn Ala Ser Thr Ala Ala Glu Gly Leu
2785                2790                2795                2800
Cys Lys Trp Val Ile Ala Met Asp Ser Tyr Asp Lys Val Ala Lys Ile
                2805                2810                2815    
Val Ala Pro Lys Lys Ile Lys Leu Ala Ala Ala Glu Gly Glu Leu Lys
            2820                2825                2830        
Ile Ala Met Asp Gly Leu Arg Lys Lys Gln Ala Ala Leu Lys Glu Val
        2835                2840                2845            
Gln Asp Lys Leu Ala Arg Leu Gln Asp Thr Leu Glu Leu Asn Lys Gln
    2850                2855                2860                
Lys Lys Ala Asp Leu Glu Asn Gln Val Asp Leu Cys Ser Lys Lys Leu
2865                2870                2875                2880
Glu Arg Ala Glu Gln Leu Ile Gly Gly Leu Gly Gly Glu Lys Thr Arg
                2885                2890                2895    
Trp Ser His Thr Ala Leu Glu Leu Gly Gln Leu Tyr Ile Asn Leu Thr
            2900                2905                2910        
Gly Asp Ile Leu Ile Ser Ser Gly Val Val Ala Tyr Leu Gly Ala Phe
        2915                2920                2925            
Thr Ser Thr Tyr Arg Gln Asn Gln Thr Lys Glu Trp Thr Thr Leu Cys
    2930                2935                2940                
Lys Gly Arg Asp Ile Pro Cys Ser Asp Asp Cys Ser Leu Met Gly Thr
2945                2950                2955                2960
Leu Gly Glu Ala Val Thr Ile Arg Thr Trp Asn Ile Ala Gly Leu Pro
                2965                2970                2975    
Ser Asp Ser Phe Ser Ile Asp Asn Gly Ile Ile Ile Met Asn Ala Arg
            2980                2985                2990        
Arg Trp Pro Leu Met Ile Asp Pro Gln Ser Gln Ala Asn Lys Trp Ile
        2995                3000                3005            
Lys Asn Met Glu Lys Ala Asn Ser Leu Tyr Val Ile Lys Leu Ser Glu
    3010                3015                3020                
Pro Asp Tyr Val Arg Thr Leu Glu Asn Cys Ile Gln Phe Gly Thr Pro
3025                3030                3035                3040
Val Leu Leu Glu Asn Val Gly Glu Glu Leu Asp Pro Ile Leu Glu Pro
                3045                3050                3055    
Leu Leu Leu Lys Gln Thr Phe Lys Gln Gly Gly Ser Thr Cys Ile Arg
            3060                3065                3070        
Leu Gly Asp Ser Thr Ile Glu Tyr Ala Pro Asp Phe Arg Phe Tyr Ile
        3075                3080                3085            
Thr Thr Lys Leu Arg Asn Pro His Tyr Leu Pro Glu Thr Ser Val Lys
    3090                3095                3100                
Val Thr Leu Leu Asn Phe Met Ile Thr Pro Glu Gly Met Gln Asp Gln
3105                3110                3115                3120
Leu Leu Gly Ile Val Val Ala Gln Glu Arg Pro Asp Leu Glu Glu Glu
                3125                3130                3135    
Lys Gln Ala Leu Ile Leu Gln Gly Ala Glu Asn Lys Arg Gln Leu Lys
            3140                3145                3150        
Glu Ile Glu Asp Lys Ile Leu Glu Val Leu Ser Ser Ser Glu Gly Asn
        3155                3160                3165            
Ile Leu Glu Asp Glu Thr Ala Ile Lys Ile Leu Ser Ser Ser Lys Ala
    3170                3175                3180                
Leu Ala Asn Glu Ile Ser Gln Lys Gln Glu Val Ala Glu Glu Thr Glu
3185                3190                3195                3200
Lys Lys Ile Asp Thr Thr Arg Met Gly Tyr Arg Pro Ile Ala Ile His
                3205                3210                3215    
Ser Ser Ile Leu Phe Phe Ser Leu Ala Asp Leu Ala Asn Ile Glu Pro
            3220                3225                3230        
Met Tyr Gln Tyr Ser Leu Thr Trp Phe Ile Asn Leu Phe Ile Leu Ser
        3235                3240                3245            
Ile Glu Asn Ser Glu Lys Ser Glu Ile Leu Ala Lys Arg Leu Gln Ile
    3250                3255                3260                
Leu Lys Asp His Phe Thr Tyr Ser Leu Tyr Val Asn Val Cys Arg Ser
3265                3270                3275                3280
Leu Phe Glu Lys Asp Lys Leu Leu Phe Ser Phe Cys Leu Thr Ile Asn
                3285                3290                3295    
Leu Leu Leu His Glu Arg Ala Ile Asn Lys Ala Glu Trp Arg Phe Leu
            3300                3305                3310        
Leu Thr Gly Gly Ile Gly Leu Asp Asn Pro Tyr Ala Asn Pro Cys Thr
        3315                3320                3325            
Trp Leu Pro Gln Lys Ser Trp Asp Glu Ile Cys Arg Leu Asp Asp Leu
    3330                3335                3340                
Pro Ala Phe Lys Thr Ile Arg Arg Glu Phe Met Arg Leu Lys Asp Gly
3345                3350                3355                3360
Trp Lys Lys Val Tyr Asp Ser Leu Glu Pro His His Glu Val Phe Pro
                3365                3370                3375    
Glu Glu Trp Glu Asp Lys Ala Asn Glu Phe Gln Arg Met Leu Ile Ile
            3380                3385                3390        
Arg Cys Leu Arg Pro Asp Lys Val Ile Pro Met Leu Gln Glu Phe Ile
        3395                3400                3405            
Ile Asn Arg Leu Gly Arg Ala Phe Ile Glu Pro Pro Pro Phe Asp Leu
    3410                3415                3420                
Ala Lys Ala Phe Gly Asp Ser Asn Cys Cys Ala Pro Leu Ile Phe Val
3425                3430                3435                3440
Leu Ser Pro Gly Ala Asp Pro Met Ala Ala Leu Leu Lys Phe Ala Asp
                3445                3450                3455    
Asp Gln Gly Tyr Gly Gly Ser Lys Leu Ser Ser Leu Ser Leu Gly Gln
            3460                3465                3470        
Gly Gln Gly Pro Ile Ala Met Lys Met Leu Glu Lys Ala Val Lys Glu
        3475                3480                3485            
Gly Thr Trp Val Val Leu Gln Asn Cys His Leu Ala Thr Ser Trp Met
    3490                3495                3500                
Pro Thr Leu Glu Lys Val Cys Glu Glu Leu Ser Pro Glu Ser Thr His
3505                3510                3515                3520
Pro Asp Phe Arg Met Trp Leu Thr Ser Tyr Pro Ser Pro Asn Phe Pro
                3525                3530                3535    
Val Ser Val Leu Gln Asn Gly Val Lys Met Thr Asn Glu Ala Pro Lys
            3540                3545                3550        
Gly Leu Arg Ala Asn Ile Ile Arg Ser Tyr Leu Met Asp Pro Ile Ser
        3555                3560                3565            
Asp Pro Glu Phe Phe Gly Ser Cys Lys Lys Pro Glu Glu Phe Lys Lys
    3570                3575                3580                
Leu Leu Tyr Gly Leu Cys Phe Phe His Ala Leu Val Gln Glu Arg Arg
3585                3590                3595                3600
Lys Phe Gly Pro Leu Gly Trp Asn Ile Pro Tyr Glu Phe Asn Glu Thr
                3605                3610                3615    
Asp Leu Arg Ile Ser Val Gln Gln Leu His Met Phe Leu Asn Gln Tyr
            3620                3625                3630        
Glu Glu Leu Pro Tyr Glu Ala Leu Arg Tyr Met Thr Gly Glu Cys Asn
        3635                3640                3645            
Tyr Gly Gly Arg Val Thr Asp Asp Trp Asp Arg Arg Thr Leu Arg Ser
    3650                3655                3660                
Ile Leu Asn Lys Phe Phe Asn Pro Glu Leu Val Glu Asn Ser Asp Tyr
3665                3670                3675                3680
Lys Phe Asp Ser Ser Gly Ile Tyr Phe Val Pro Pro Ser Gly Asp His
                3685                3690                3695    
Lys Ser Tyr Ile Glu Tyr Thr Lys Thr Leu Pro Leu Thr Pro Ala Pro
            3700                3705                3710        
Glu Ile Phe Gly Met Asn Ala Asn Ala Asp Ile Thr Lys Asp Gln Ser
        3715                3720                3725            
Glu Thr Gln Leu Leu Phe Asp Asn Ile Leu Leu Thr Gln Ser Arg Ser
    3730                3735                3740                
Ala Gly Ala Gly Ala Lys Ser Ser Asp Glu Val Val Asn Glu Val Ala
3745                3750                3755                3760
Ser Asp Ile Leu Gly Lys Leu Pro Asn Asn Phe Asp Ile Glu Ala Ala
                3765                3770                3775    
Met Arg Arg Tyr Pro Thr Thr Tyr Thr Gln Ser Met Asn Thr Val Leu
            3780                3785                3790        
Val Gln Glu Met Gly Arg Phe Asn Lys Leu Leu Lys Thr Ile Arg Asp
        3795                3800                3805            
Ser Cys Val Asn Ile Gln Lys Ala Ile Lys Gly Leu Ala Val Met Ser
    3810                3815                3820                
Thr Asp Leu Glu Glu Val Val Ser Ser Ile Leu Asn Val Lys Ile Pro
3825                3830                3835                3840
Glu Met Trp Met Gly Lys Ser Tyr Pro Ser Leu Lys Pro Leu Gly Ser
                3845                3850                3855    
Tyr Val Asn Asp Phe Leu Ala Arg Leu Lys Phe Leu Gln Gln Trp Tyr
            3860                3865                3870        
Glu Val Gly Pro Pro Pro Val Phe Trp Leu Ser Gly Phe Phe Phe Thr
        3875                3880                3885            
Gln Ala Phe Leu Thr Gly Ala Gln Gln Asn Tyr Ala Arg Lys Tyr Thr
    3890                3895                3900                
Ile Pro Ile Asp Leu Leu Gly Phe Asp Tyr Glu Val Met Glu Asp Lys
3905                3910                3915                3920
Glu Tyr Lys His Pro Pro Glu Asp Gly Val Phe Ile His Gly Leu Phe
                3925                3930                3935    
Leu Asp Gly Ala Ser Trp Asn Arg Lys Ile Lys Lys Leu Ala Glu Ser
            3940                3945                3950        
His Pro Lys Ile Leu Tyr Asp Thr Val Pro Val Met Trp Leu Lys Pro
        3955                3960                3965            
Cys Lys Arg Ala Asp Ile Pro Lys Arg Pro Ser Tyr Val Ala Pro Leu
    3970                3975                3980                
Tyr Lys Thr Ser Glu Arg Arg Gly Val Leu Ser Thr Thr Gly His Ser
3985                3990                3995                4000
Thr Asn Phe Val Ile Ala Met Thr Leu Pro Ser Asp Gln Pro Lys Glu
                4005                4010                4015    
His Trp Ile Gly Arg Gly Val Ala Leu Leu Cys Gln Leu Asn Ser
            4020                4025                4030    


<210> 6988
<211> 4024
<212> PRT
<213> Homo sapiens

<400> 6988
Met Ser Ser Glu Gln Asp Lys Ser Ala Ser Lys Glu Lys Ser Lys Lys
 1               5                  10                  15      
Pro Val Arg Phe Leu Pro Gln Leu Ser Met Glu Lys Leu Ala Ser Lys
            20                  25                  30          
Glu Lys Phe Lys Ala Pro Ala Arg Ala Leu Pro Gln Leu Ser Met Val
        35                  40                  45              
Ser Thr Lys Pro His Trp Gln Gln Ala Ala Pro Ser Phe His Leu Ser
    50                  55                  60                  
Val Lys Gln Asp Asp Glu Ser Pro Glu Pro Phe Ser Val Lys Asn Glu
65                  70                  75                  80  
Gln Ser His Ala Glu Tyr Met Glu Arg Phe Gly Lys Lys Gly Lys Leu
                85                  90                  95      
Pro His Gln Val Asp Asp Ser Tyr Val Gly Pro Ser Thr Ser Lys Ser
            100                 105                 110         
Lys Gly Lys Ser Pro His Lys Glu Arg Glu Asn Phe Arg Ser Thr Leu
        115                 120                 125             
Val Asn Val Ile Met Gln Gln Asp Ala Asp Leu Asp Ser Ala Val Pro
    130                 135                 140                 
Asp Gly Ser Thr Ile Pro Lys Pro Thr Ala Ser Ala Ile Glu Lys Asp
145                 150                 155                 160 
Ile Leu Arg Tyr Tyr Tyr Tyr Ile His His Gly Ile Asp Thr Asp His
                165                 170                 175     
Val Ala Pro Met Glu Asp Ser Trp Leu Glu His Val Leu Asp Leu Val
            180                 185                 190         
Pro Gln His Leu Lys Val Phe Thr Asp Ser Ile Val Thr Leu Ser Asp
        195                 200                 205             
Glu Met Arg Glu Asp Tyr Leu Leu Ser Val Arg Lys Ser Ile Val Asp
    210                 215                 220                 
Phe Val Leu Lys Asp Pro Arg Glu Lys Gly Asp Asp Lys Lys Thr Asp
225                 230                 235                 240 
Glu Leu Pro Ala His Arg Ala Glu Met Glu Ile Leu Pro Lys Pro Trp
                245                 250                 255     
Arg Lys Ser Phe Leu Ala Ala Ser Ser Tyr Ile Arg Asp His Leu Asn
            260                 265                 270         
Ala Met Asn Pro Thr Met Leu Ala Val Leu Asp Leu Trp His Thr Asn
        275                 280                 285             
Phe Lys Lys Leu Arg Leu Val Asp Ile Lys Glu Phe His Asn Cys Gln
    290                 295                 300                 
Asp Ala Leu Glu Leu Ser Ser Phe Gln Asn Ile Ile Met Arg His Met
305                 310                 315                 320 
Asp Ser Ala Lys Glu Thr Leu Leu Lys Met Trp Phe Pro Glu Val Gln
                325                 330                 335     
Asn Ile Tyr Tyr Gln Gly Asn Lys Lys Lys Gln Leu Pro Thr Gly Asp
            340                 345                 350         
Ser Ser Ala Lys Leu Glu Ser Phe Phe Asn Cys Ala Ala Ala Leu Met
        355                 360                 365             
Thr Leu Gln Leu Gln Asp Leu Thr Leu Val Ser Met Gln Asp Phe Thr
    370                 375                 380                 
Asp Leu Ile Ala Gln Pro Pro Asp Ser Val Arg Ala Phe Glu His Pro
385                 390                 395                 400 
Gly Phe Ile Met Arg Leu Ile Leu Asp Asn Asp Thr Ile Lys Phe Glu
                405                 410                 415     
Pro Glu Leu Ser Asp Tyr Ile Asp Ile Phe Leu Asn Val Tyr Asp Val
            420                 425                 430         
Met Ile Lys Ala Val Ser Phe Val Pro Arg Val Glu Thr Lys Leu Tyr
        435                 440                 445             
Ser Lys Trp Glu Ser Lys Ser Lys Pro Thr Thr Leu Lys Pro Ile Ile
    450                 455                 460                 
Leu Asn Glu Ile Val Asp Ala His Lys Glu Lys Ile Lys Glu Val Ile
465                 470                 475                 480 
Met Lys Glu Ser Val Ala Pro Thr Glu His Leu Arg Leu Tyr Asp Lys
                485                 490                 495     
Tyr Asp Phe Leu Ile Thr Arg Lys Ala Glu Arg Asp Val Asp Asn Phe
            500                 505                 510         
Leu Ala Glu Asn His Ser Tyr Glu Lys Ile Ile Asp Glu Ile Cys Lys
        515                 520                 525             
Tyr Gln Lys Leu Ile Glu Glu Ile Gln Tyr Thr Ser Ile Lys Thr Ile
    530                 535                 540                 
Arg Leu Gly Met Phe Glu Met His Cys Glu Glu Leu Ile Arg Ala Leu
545                 550                 555                 560 
Val Lys Arg Ala Asp Ile Ile Cys Gly Lys Leu Leu Ala Lys Met Phe
                565                 570                 575     
Arg Asp His Gln Glu Val Asn Thr Arg Leu Cys Asp Glu Phe Glu Arg
            580                 585                 590         
Ile Ala Glu Lys Ala Leu Ser Thr Pro Pro Asn Thr Ala Glu Leu Met
        595                 600                 605             
Glu Met Lys Ala Tyr Ile Gln Lys Val Glu Val Thr Asp Met Ile Glu
    610                 615                 620                 
Leu Glu Gln Arg Leu Val Asp Ser Lys Asn Cys Leu Ala Phe Leu Ile
625                 630                 635                 640 
Glu Tyr Val Asn Phe Ser Pro Ala Asp Met Arg Leu Asn Asn Ser Val
                645                 650                 655     
Phe Gln Trp Tyr Gly Arg Met Gly Glu Ile Phe Glu Glu His Arg Lys
            660                 665                 670         
Ile Ile Lys Glu Lys Ile Glu Gln Tyr Gln Glu Gly Leu Lys Leu Arg
        675                 680                 685             
Cys Glu Arg Phe Val Glu Glu Leu Glu Ser Tyr Ala Lys Gln Ser Glu
    690                 695                 700                 
Glu Phe Tyr Ser Phe Gly Asp Leu Gln Asp Val Gln Arg Tyr Leu Lys
705                 710                 715                 720 
Lys Ala Gln Ile Leu Asn Gly Lys Leu Asp Leu Ala Ala Asp Lys Ile
                725                 730                 735     
Glu Gln Phe Asn Ala Glu Glu Glu Ala Phe Gly Trp Leu Pro Ser Val
            740                 745                 750         
Tyr Pro Gln Arg Lys Lys Ile Gln Asp Gly Leu Asn Pro Tyr Leu Arg
        755                 760                 765             
Leu Tyr Glu Thr Ala Val Glu Phe Ser Ser Asn Tyr Arg Ala Trp Thr
    770                 775                 780                 
Glu Gly Pro Tyr His Lys Val Asn Pro Asp Gln Val Glu Ala Asp Ile
785                 790                 795                 800 
Gly Asn Tyr Trp Arg Gly Leu Tyr Lys Leu Glu Lys Thr Phe His Asp
                805                 810                 815     
Ser Pro Tyr Ala Leu Ala Met Thr Lys Lys Val Arg Ser Lys Val Glu
            820                 825                 830         
Asp Phe Lys Gln His Ile Pro Leu Ile Gln Val Ile Cys Asn Pro Gly
        835                 840                 845             
Leu Arg Pro Arg His Trp Glu Ala Met Ser Ala Ile Val Gly Tyr Pro
    850                 855                 860                 
Leu Gln Pro Ser Asp Asp Ser Thr Val Ser Ser Phe Leu Asp Met Asn
865                 870                 875                 880 
Leu Glu Pro Tyr Ile Asp Arg Phe Glu Gly Ile Ser Glu Ala Ala Ser
                885                 890                 895     
Lys Glu Tyr Ser Leu Glu Lys Ala Met Glu Lys Met Ile Thr Glu Trp
            900                 905                 910         
Asp Ala Val Glu Phe Val Ile His Ser Tyr Arg Glu Thr Gly Thr Phe
        915                 920                 925             
Ile Leu Ala Ser Val Asp Glu Ile Gln Met Leu Leu Asp Asp His Ile
    930                 935                 940                 
Ile Lys Thr Gln Thr Met Arg Gly Ser Pro Phe Ile Lys Pro Tyr Glu
945                 950                 955                 960 
Lys Gln Met Arg Glu Trp Glu Gly Lys Leu Leu Leu Leu Gln Glu Ile
                965                 970                 975     
Leu Asp Glu Trp Leu Lys Val Gln Ala Thr Trp Leu Tyr Leu Glu Pro
            980                 985                 990         
Ile Phe Ser Ser Pro Asp Ile Met Ser Gln Met Pro Glu Glu Gly Arg
        995                 1000                1005            
Arg Phe Thr Ala Val Asp Lys Thr Trp Arg Asp Ile Met Arg Ser Val
    1010                1015                1020                
Met Gln Asp Lys His Val Leu Thr Val Val Thr Ile Asp Arg Met Leu
1025                1030                1035                1040
Glu Arg Leu Lys Lys Ser Asn Glu Leu Leu Glu Leu Ile Leu Lys Gly
                1045                1050                1055    
Leu Asn Glu Tyr Leu Glu Lys Lys Arg Leu Phe Phe Pro Arg Phe Phe
            1060                1065                1070        
Phe Leu Ser Asn Asp Glu Leu Leu Glu Ile Leu Ser Glu Thr Lys Asp
        1075                1080                1085            
Pro Thr Arg Val Gln Pro His Leu Lys Lys Cys Phe Glu Gly Ile Ala
    1090                1095                1100                
Lys Val Glu Phe Thr Glu Thr Leu Asp Ile Thr His Met Lys Ser Ser
1105                1110                1115                1120
Glu Gly Glu Val Val Glu Leu Ile Glu Ile Ile Ser Thr Ala Lys Ala
                1125                1130                1135    
Arg Gly Gln Val Glu Lys Trp Leu Val Glu Leu Glu Arg Val Met Ile
            1140                1145                1150        
Asn Ser Ile His Lys Val Thr Gly Asp Ala Thr Phe Ala Tyr Thr Lys
        1155                1160                1165            
Tyr Glu Arg Ile Asn Trp Val Arg Asp Trp Pro Gly Gln Thr Val Leu
    1170                1175                1180                
Cys Val Ser Gln Ile Phe Trp Thr Lys Glu Val Gln Thr Ala Ile Pro
1185                1190                1195                1200
Met Gly Ile Lys Ala Leu Glu Gln Tyr Leu Lys Thr Cys Asn Arg Gln
                1205                1210                1215    
Ile Asp Asp Ile Val Thr Leu Val Arg Gly Lys Leu Ser Met Gln Asn
            1220                1225                1230        
Arg Val Thr Leu Gly Ala Leu Val Val Leu Asp Val His Ala Arg Asp
        1235                1240                1245            
Val Leu Ser Ser Leu Val Lys Lys Asn Ile Ser Asp Asp Ser Asp Phe
    1250                1255                1260                
Glu Trp Leu Ser Gln Leu Arg Tyr Tyr Trp Gln Glu Asn His Leu Glu
1265                1270                1275                1280
Thr Lys Met Ile Asn Ala Gly Leu Arg Tyr Gly Tyr Glu Tyr Leu Gly
                1285                1290                1295    
Asn Ser Pro Arg Leu Val Ile Thr Pro Leu Thr Asp Arg Cys Tyr Arg
            1300                1305                1310        
Thr Leu Phe Gly Ala Leu His Leu His Leu Gly Gly Ala Pro Glu Gly
        1315                1320                1325            
Pro Ala Gly Thr Gly Lys Thr Glu Thr Thr Lys Asp Leu Ala Lys Ala
    1330                1335                1340                
Val Ala Lys Gln Cys Val Val Phe Asn Cys Ser Asp Gly Leu Asp Tyr
1345                1350                1355                1360
Leu Ala Leu Gly Lys Phe Phe Lys Gly Leu Leu Ser Cys Gly Ala Trp
                1365                1370                1375    
Ala Cys Phe Asp Glu Phe Asn Arg Ile Asp Leu Glu Val Leu Ser Val
            1380                1385                1390        
Val Ala Gln Gln Ile Leu Thr Ile Gln Arg Gly Ile Asn Ala Gly Ala
        1395                1400                1405            
Asp Ile Leu Met Phe Glu Gly Thr Glu Leu Lys Leu Asp Pro Thr Cys
    1410                1415                1420                
Ala Val Phe Ile Thr Met Asn Pro Gly Tyr Ala Gly Arg Ser Glu Leu
1425                1430                1435                1440
Pro Asp Asn Leu Lys Ala Leu Phe Arg Thr Val Ala Met Met Val Pro
                1445                1450                1455    
Asp Tyr Ala Met Ile Ala Glu Ile Val Leu Tyr Ser Cys Gly Phe Val
            1460                1465                1470        
Thr Ala Arg Pro Leu Ser Val Lys Ile Val Ala Thr Tyr Arg Leu Cys
        1475                1480                1485            
Ser Glu Gln Leu Ser Ser Gln His His Tyr Asp Tyr Gly Met Arg Ala
    1490                1495                1500                
Val Lys Ser Val Leu Thr Ala Ala Gly Asn Leu Lys Leu Lys Tyr Pro
1505                1510                1515                1520
Asn Glu Asn Glu Glu Ile Leu Leu Leu Arg Ser Ile Ile Asp Val Asn
                1525                1530                1535    
Leu Pro Lys Phe Leu Ser His Asp Leu Pro Leu Phe Glu Gly Ile Thr
            1540                1545                1550        
Ser Asp Leu Phe Pro Gly Val Lys Leu Pro Lys Pro Asp Tyr Asn Asp
        1555                1560                1565            
Leu Leu Ala Ala Ile Lys Asp Asn Cys Ala Ser Met Asn Leu Gln Met
    1570                1575                1580                
Thr Ala Phe Phe Ser Glu Lys Ile Leu Gln Val Tyr Glu Met Met Ile
1585                1590                1595                1600
Val Arg His Gly Phe Met Ile Val Gly Glu Pro Phe Gly Gly Lys Thr
                1605                1610                1615    
Ser Ala Tyr Arg Val Leu Ala Gly Ala Leu Asn Asp Ile Cys Glu Lys
            1620                1625                1630        
Gly Leu Met Glu Glu Asn Lys Val Gln Ile Thr Val Leu Asn Pro Lys
        1635                1640                1645            
Ser Val Thr Met Gly Gln Leu Tyr Gly Gln Phe Asp Ser Val Ser His
    1650                1655                1660                
Glu Trp Ser Asp Gly Val Leu Ala Val Ser Phe Arg Ala Phe Ala Ser
1665                1670                1675                1680
Ser Val Thr Pro Asp Arg Lys Trp Leu Ile Phe Asp Gly Pro Val Asp
                1685                1690                1695    
Ala Val Trp Ile Glu Asn Met Asn Thr Val Leu Asp Asp Asn Lys Lys
            1700                1705                1710        
Leu Cys Leu Met Ser Gly Glu Ile Ile Gln Met Ser Pro Gln Met Asn
        1715                1720                1725            
Leu Ile Phe Glu Pro Met Asp Leu Glu Val Ala Ser Pro Ala Thr Val
    1730                1735                1740                
Ser Arg Cys Gly Met Ile Tyr Met Glu Pro His Met Leu Gly Trp Arg
1745                1750                1755                1760
Pro Leu Met Leu Ser Trp Val Asn Leu Leu Pro Ala Ser Val Ser Val
                1765                1770                1775    
Ile Gln Lys Glu Phe Ile Met Gly Leu Phe Asp Arg Met Val Pro Val
            1780                1785                1790        
Ser Val Glu Phe Ile Arg Lys His Thr Lys Glu Leu Ser Pro Thr Ser
        1795                1800                1805            
Asp Thr Asn Leu Val Arg Ser Leu Met Asn Leu Ile Asp Cys Phe Met
    1810                1815                1820                
Asp Asp Phe Ala Asp Glu Val Lys Leu Lys Glu Arg Asn Asp Arg Glu
1825                1830                1835                1840
Thr Tyr Ser Leu Leu Glu Gly Ile Phe Leu Phe Ser Leu Ile Trp Ser
                1845                1850                1855    
Val Gly Ala Ser Cys Thr Asp Asp Asp Arg Leu Lys Phe Asn Lys Ile
            1860                1865                1870        
Leu Arg Glu Leu Met Glu Ser Pro Ile Ser Asp Arg Thr Arg Asn Thr
        1875                1880                1885            
Phe Lys Leu Gln Ser Gly Thr Glu Gln Thr Ser Ser Lys Ala Leu Thr
    1890                1895                1900                
Val Pro Phe Pro Glu Lys Gly Thr Ile Tyr Asp Tyr Gln Phe Val Thr
1905                1910                1915                1920
Glu Gly Ile Gly Lys Trp Glu Pro Trp Ile Lys Lys Leu Lys Glu Ala
                1925                1930                1935    
Pro Pro Ile Pro Lys Asp Val Met Phe Asn Glu Ile Ile Val Pro Thr
            1940                1945                1950        
Leu Asp Thr Ile Arg Tyr Ser Ala Leu Met Glu Leu Leu Thr Thr His
        1955                1960                1965            
Gln Lys Pro Ser Ile Phe Val Gly Pro Thr Gly Thr Gly Lys Ser Val
    1970                1975                1980                
Tyr Ile Thr Asn Phe Leu Leu Asn Gln Leu Asn Lys Glu Ile Tyr Lys
1985                1990                1995                2000
Pro Leu Leu Ile Asn Phe Ser Ala Gln Thr Thr Ala Ala Gln Thr Gln
                2005                2010                2015    
Asn Ile Val Met Ser Lys Leu Asp Lys Arg Arg Lys Gly Val Phe Gly
            2020                2025                2030        
Pro Pro Leu Gly Lys Arg Met Val Val Phe Val Asp Asp Val Asn Met
        2035                2040                2045            
Pro Ala Arg Glu Val Tyr Gly Ala Gln Pro Pro Ile Glu Leu Leu Arg
    2050                2055                2060                
Gln Trp Leu Asp His Trp Asn Trp Tyr Asp Leu Lys Asp Cys Ser Met
2065                2070                2075                2080
Ile Lys Leu Val Asp Ile Gln Ile Met Cys Ala Met Gly Pro Pro Gly
                2085                2090                2095    
Gly Gly Arg Asn Pro Val Thr Pro Arg Tyr Met Arg His Phe Asn Ile
            2100                2105                2110        
Ile Thr Ile Asn Glu Phe Ser Asp Lys Ser Met Tyr Thr Ile Phe Ser
        2115                2120                2125            
Arg Ile Leu Thr Trp His Leu Glu Ile Cys Tyr Lys Phe Pro Asp Glu
    2130                2135                2140                
Phe Leu Asp Leu Thr Thr Gln Ile Val Asn Gly Thr Met Thr Leu Tyr
2145                2150                2155                2160
Lys Glu Ala Met Lys Asn Leu Leu Pro Thr Pro Ala Lys Ser His Tyr
                2165                2170                2175    
Leu Phe Asn Leu Arg Asp Phe Ser Arg Val Ile Gln Gly Val Cys Leu
            2180                2185                2190        
Ser Arg Pro Glu Thr Thr Glu Thr Thr Glu Val Ile Lys Arg Leu Trp
        2195                2200                2205            
Val His Glu Val Leu Arg Val Tyr Tyr Asp Arg Leu Leu Asp Asn Thr
    2210                2215                2220                
Asp Arg Ser Trp Leu Ile Asn Tyr Ile Gln Glu Ile Leu Arg Asn Tyr
2225                2230                2235                2240
Met Tyr Glu Asp Phe His Glu Leu Phe Gln Arg Leu Asp Phe Asp Asn
                2245                2250                2255    
Asp Gly Met Val Glu Ala Asp Asp Leu Arg Ser Leu Met Phe Cys Asp
            2260                2265                2270        
Phe His Asp Pro Lys Arg Glu Asp Thr Asn Tyr Arg Glu Ile Ala Asp
        2275                2280                2285            
Val Asp Asn Leu Arg Met Ile Val Glu Ile His Leu Glu Glu Tyr Asn
    2290                2295                2300                
Asn Ile Ser Lys Lys Pro Met Asn Leu Val Leu Phe Arg Phe Ala Ile
2305                2310                2315                2320
Glu His Ile Ser Arg Ile Ser Arg Ile Leu Lys Gln Pro Arg Ser His
                2325                2330                2335    
Ala Leu Leu Val Gly Val Gly Gly Ser Gly Arg Gln Ser Val Thr Arg
            2340                2345                2350        
Leu Ala Ala His Met Ala Asp Tyr Ser Val Phe Gln Val Glu Ile Ser
        2355                2360                2365            
Lys Gly Tyr Asp Thr Thr Glu Trp His Glu Asp Leu Lys Val Ile Leu
    2370                2375                2380                
Arg Lys Cys Ala Glu Gly Glu Met Gln Gly Val Phe Leu Phe Thr Asp
2385                2390                2395                2400
Thr Gln Ile Lys Glu Glu Ser Phe Leu Glu Asp Val Ser Asn Leu Leu
                2405                2410                2415    
Asn Ala Gly Glu Ile Pro Asn Leu Phe Ala Leu Asp Glu Lys Gln Glu
            2420                2425                2430        
Ile Cys Asp Lys Met Arg Gln Leu Asp Arg Gln Arg Asp Lys Thr Lys
        2435                2440                2445            
Gln Thr Asp Gly Ser Pro Ile Ala Leu Phe Asn Met Phe Ile Asp His
    2450                2455                2460                
Cys Arg Ser Gln Leu His Val Val Leu Ala Met Ser Pro Ile Gly Asp
2465                2470                2475                2480
Ala Phe Arg Asn Arg Leu Arg Lys Phe Pro Ala Leu Val Asn Cys Cys
                2485                2490                2495    
Thr Ile Asp Trp Phe Gln Ser Trp Pro Glu Asp Ala Leu Gln Ala Val
            2500                2505                2510        
Ala Ser Arg Phe Leu Glu Glu Ile Glu Met Ser Glu Glu Ile Arg Asp
        2515                2520                2525            
Gly Cys Ile Asp Met Cys Lys Ser Phe His Thr Ser Thr Ile Asp Leu
    2530                2535                2540                
Ser Lys Ser Phe Phe Val Glu Leu Gln Arg Tyr Asn Tyr Val Thr Pro
2545                2550                2555                2560
Thr Ser Tyr Leu Glu Leu Ile Ser Thr Phe Lys Leu Leu Leu Glu Lys
                2565                2570                2575    
Lys Arg Ser Glu Val Met Lys Met Lys Lys Arg Tyr Glu Val Gly Leu
            2580                2585                2590        
Glu Lys Leu Asp Ser Ala Ser Ser Gln Val Ala Thr Met Gln Met Glu
        2595                2600                2605            
Leu Glu Ala Leu His Pro Gln Leu Lys Val Ala Ser Lys Glu Val Asp
    2610                2615                2620                
Glu Met Met Ile Met Ile Glu Lys Glu Ser Val Glu Val Ala Lys Thr
2625                2630                2635                2640
Glu Lys Ile Val Lys Ala Asp Glu Thr Ile Ala Asn Glu Gln Ala Met
                2645                2650                2655    
Ala Ser Lys Ala Ile Lys Asp Glu Cys Asp Ala Asp Leu Ala Gly Ala
            2660                2665                2670        
Leu Pro Ile Leu Glu Ser Ala Leu Ala Ala Leu Asp Thr Leu Thr Ala
        2675                2680                2685            
Gln Asp Ile Thr Val Val Lys Ser Met Lys Ser Pro Pro Ala Gly Val
    2690                2695                2700                
Lys Leu Val Met Glu Ala Ile Cys Ile Leu Lys Gly Ile Lys Ala Asp
2705                2710                2715                2720
Lys Ile Pro Asp Pro Thr Gly Ser Gly Lys Lys Ile Glu Asp Phe Trp
                2725                2730                2735    
Gly Pro Ala Lys Arg Leu Leu Gly Asp Met Arg Phe Leu Gln Ser Leu
            2740                2745                2750        
His Glu Tyr Asp Lys Asp Asn Ile Pro Pro Ala Tyr Met Asn Ile Ile
        2755                2760                2765            
Arg Lys Asn Tyr Ile Pro Asn Pro Asp Phe Val Pro Glu Lys Ile Arg
    2770                2775                2780                
Asn Ala Ser Thr Ala Ala Glu Gly Leu Cys Lys Trp Val Ile Ala Met
2785                2790                2795                2800
Asp Ser Tyr Asp Lys Val Ala Lys Ile Val Ala Pro Lys Lys Ile Lys
                2805                2810                2815    
Leu Ala Ala Ala Glu Gly Glu Leu Lys Ile Ala Met Asp Gly Leu Arg
            2820                2825                2830        
Lys Lys Gln Ala Ala Leu Lys Glu Val Gln Asp Lys Leu Ala Arg Leu
        2835                2840                2845            
Gln Asp Thr Leu Glu Leu Asn Lys Gln Lys Lys Ala Asp Leu Glu Asn
    2850                2855                2860                
Gln Val Asp Leu Cys Ser Lys Lys Leu Glu Arg Ala Glu Gln Leu Ile
2865                2870                2875                2880
Gly Gly Leu Gly Gly Glu Lys Thr Arg Trp Ser His Thr Ala Leu Glu
                2885                2890                2895    
Leu Gly Gln Leu Tyr Ile Asn Leu Thr Gly Asp Ile Leu Ile Ser Ser
            2900                2905                2910        
Gly Val Val Ala Tyr Leu Gly Ala Phe Thr Ser Thr Tyr Arg Gln Asn
        2915                2920                2925            
Gln Thr Lys Glu Trp Thr Thr Leu Cys Lys Gly Arg Asp Ile Pro Cys
    2930                2935                2940                
Ser Asp Asp Cys Ser Leu Met Gly Thr Leu Gly Glu Ala Val Thr Ile
2945                2950                2955                2960
Arg Thr Trp Asn Ile Ala Gly Leu Pro Ser Asp Ser Phe Ser Ile Asp
                2965                2970                2975    
Asn Gly Ile Ile Ile Met Asn Ala Arg Arg Trp Pro Leu Met Ile Asp
            2980                2985                2990        
Pro Gln Ser Gln Ala Asn Lys Trp Ile Lys Asn Met Glu Lys Ala Asn
        2995                3000                3005            
Ser Leu Tyr Val Ile Lys Leu Ser Glu Pro Asp Tyr Val Arg Thr Leu
    3010                3015                3020                
Glu Asn Cys Ile Gln Phe Gly Thr Pro Val Leu Leu Glu Asn Val Gly
3025                3030                3035                3040
Glu Glu Leu Asp Pro Ile Leu Glu Pro Leu Leu Leu Lys Gln Thr Phe
                3045                3050                3055    
Lys Gln Gly Gly Ser Thr Cys Ile Arg Leu Gly Asp Ser Thr Ile Glu
            3060                3065                3070        
Tyr Ala Pro Asp Phe Arg Phe Tyr Ile Thr Thr Lys Leu Arg Asn Pro
        3075                3080                3085            
His Tyr Leu Pro Glu Thr Ser Val Lys Val Thr Leu Leu Asn Phe Met
    3090                3095                3100                
Ile Thr Pro Glu Gly Met Gln Asp Gln Leu Leu Gly Ile Val Val Ala
3105                3110                3115                3120
Gln Glu Arg Pro Asp Leu Glu Glu Glu Lys Gln Ala Leu Ile Leu Gln
                3125                3130                3135    
Gly Ala Glu Asn Lys Arg Gln Leu Lys Glu Ile Glu Asp Lys Ile Leu
            3140                3145                3150        
Glu Val Leu Ser Ser Ser Glu Gly Asn Ile Leu Glu Asp Glu Thr Ala
        3155                3160                3165            
Ile Lys Ile Leu Ser Ser Ser Lys Ala Leu Ala Asn Glu Ile Ser Gln
    3170                3175                3180                
Lys Gln Glu Val Ala Glu Glu Thr Glu Lys Lys Ile Asp Thr Thr Arg
3185                3190                3195                3200
Met Gly Tyr Arg Pro Ile Ala Ile His Ser Ser Ile Leu Phe Phe Ser
                3205                3210                3215    
Leu Ala Asp Leu Ala Asn Ile Glu Pro Met Tyr Gln Tyr Ser Leu Thr
            3220                3225                3230        
Trp Phe Ile Asn Leu Phe Ile Leu Ser Ile Glu Asn Ser Glu Lys Ser
        3235                3240                3245            
Glu Ile Leu Ala Lys Arg Leu Gln Ile Leu Lys Asp His Phe Thr Tyr
    3250                3255                3260                
Ser Leu Tyr Val Asn Val Cys Arg Ser Leu Phe Glu Lys Asp Lys Leu
3265                3270                3275                3280
Leu Phe Ser Phe Cys Leu Thr Ile Asn Leu Leu Leu His Glu Arg Ala
                3285                3290                3295    
Ile Asn Lys Ala Glu Trp Arg Phe Leu Leu Thr Gly Gly Ile Gly Leu
            3300                3305                3310        
Asp Asn Pro Tyr Ala Asn Pro Cys Thr Trp Leu Pro Gln Lys Ser Trp
        3315                3320                3325            
Asp Glu Ile Cys Arg Leu Asp Asp Leu Pro Ala Phe Lys Thr Ile Arg
    3330                3335                3340                
Arg Glu Phe Met Arg Leu Lys Asp Gly Trp Lys Lys Val Tyr Asp Ser
3345                3350                3355                3360
Leu Glu Pro His His Glu Val Phe Pro Glu Glu Trp Glu Asp Lys Ala
                3365                3370                3375    
Asn Glu Phe Gln Arg Met Leu Ile Ile Arg Cys Leu Arg Pro Asp Lys
            3380                3385                3390        
Val Ile Pro Met Leu Gln Glu Phe Ile Ile Asn Arg Leu Gly Arg Ala
        3395                3400                3405            
Phe Ile Glu Pro Pro Pro Phe Asp Leu Ala Lys Ala Phe Gly Asp Ser
    3410                3415                3420                
Asn Cys Cys Ala Pro Leu Ile Phe Val Leu Ser Pro Gly Ala Asp Pro
3425                3430                3435                3440
Met Ala Ala Leu Leu Lys Phe Ala Asp Asp Gln Gly Tyr Gly Gly Ser
                3445                3450                3455    
Lys Leu Ser Ser Leu Ser Leu Gly Gln Gly Gln Gly Pro Ile Ala Met
            3460                3465                3470        
Lys Met Leu Glu Lys Ala Val Lys Glu Gly Thr Trp Val Val Leu Gln
        3475                3480                3485            
Asn Cys His Leu Ala Thr Ser Trp Met Pro Thr Leu Glu Lys Val Cys
    3490                3495                3500                
Glu Glu Leu Ser Pro Glu Ser Thr His Pro Asp Phe Arg Met Trp Leu
3505                3510                3515                3520
Thr Ser Tyr Pro Ser Pro Asn Phe Pro Val Ser Val Leu Gln Asn Gly
                3525                3530                3535    
Val Lys Met Thr Asn Glu Ala Pro Lys Gly Leu Arg Ala Asn Ile Ile
            3540                3545                3550        
Arg Ser Tyr Leu Met Asp Pro Ile Ser Asp Pro Glu Phe Phe Gly Ser
        3555                3560                3565            
Cys Lys Lys Pro Glu Glu Phe Lys Lys Leu Leu Tyr Gly Leu Cys Phe
    3570                3575                3580                
Phe His Ala Leu Val Gln Glu Arg Arg Lys Phe Gly Pro Leu Gly Trp
3585                3590                3595                3600
Asn Ile Pro Tyr Glu Phe Asn Glu Thr Asp Leu Arg Ile Ser Val Gln
                3605                3610                3615    
Gln Leu His Met Phe Leu Asn Gln Tyr Glu Glu Leu Pro Tyr Glu Ala
            3620                3625                3630        
Leu Arg Tyr Met Thr Gly Glu Cys Asn Tyr Gly Gly Arg Val Thr Asp
        3635                3640                3645            
Asp Trp Asp Arg Arg Thr Leu Arg Ser Ile Leu Asn Lys Phe Phe Asn
    3650                3655                3660                
Pro Glu Leu Val Glu Asn Ser Asp Tyr Lys Phe Asp Ser Ser Gly Ile
3665                3670                3675                3680
Tyr Phe Val Pro Pro Ser Gly Asp His Lys Ser Tyr Ile Glu Tyr Thr
                3685                3690                3695    
Lys Thr Leu Pro Leu Thr Pro Ala Pro Glu Ile Phe Gly Met Asn Ala
            3700                3705                3710        
Asn Ala Asp Ile Thr Lys Asp Gln Ser Glu Thr Gln Leu Leu Phe Asp
        3715                3720                3725            
Asn Ile Leu Leu Thr Gln Ser Arg Ser Ala Gly Ala Gly Ala Lys Ser
    3730                3735                3740                
Ser Asp Glu Val Val Asn Glu Val Ala Ser Asp Ile Leu Gly Lys Leu
3745                3750                3755                3760
Pro Asn Asn Phe Asp Ile Glu Ala Ala Met Arg Arg Tyr Pro Thr Thr
                3765                3770                3775    
Tyr Thr Gln Ser Met Asn Thr Val Leu Val Gln Glu Met Gly Arg Phe
            3780                3785                3790        
Asn Lys Leu Leu Lys Thr Ile Arg Asp Ser Cys Val Asn Ile Gln Lys
        3795                3800                3805            
Ala Ile Lys Gly Leu Ala Val Met Ser Thr Asp Leu Glu Glu Val Val
    3810                3815                3820                
Ser Ser Ile Leu Asn Val Lys Ile Pro Glu Met Trp Met Gly Lys Ser
3825                3830                3835                3840
Tyr Pro Ser Leu Lys Pro Leu Gly Ser Tyr Val Asn Asp Phe Leu Ala
                3845                3850                3855    
Arg Leu Lys Phe Leu Gln Gln Trp Tyr Glu Val Gly Pro Pro Pro Val
            3860                3865                3870        
Phe Trp Leu Ser Gly Phe Phe Phe Thr Gln Ala Phe Leu Thr Gly Ala
        3875                3880                3885            
Gln Gln Asn Tyr Ala Arg Lys Tyr Thr Ile Pro Ile Asp Leu Leu Gly
    3890                3895                3900                
Phe Asp Tyr Glu Val Met Glu Asp Lys Glu Tyr Lys His Pro Pro Glu
3905                3910                3915                3920
Asp Gly Val Phe Ile His Gly Leu Phe Leu Asp Gly Ala Ser Trp Asn
                3925                3930                3935    
Arg Lys Ile Lys Lys Leu Ala Glu Ser His Pro Lys Ile Leu Tyr Asp
            3940                3945                3950        
Thr Val Pro Val Met Trp Leu Lys Pro Cys Lys Arg Ala Asp Ile Pro
        3955                3960                3965            
Lys Arg Pro Ser Tyr Val Ala Pro Leu Tyr Lys Thr Ser Glu Arg Arg
    3970                3975                3980                
Gly Val Leu Ser Thr Thr Gly His Ser Thr Asn Phe Val Ile Ala Met
3985                3990                3995                4000
Thr Leu Pro Ser Asp Gln Pro Lys Glu His Trp Ile Gly Arg Gly Val
                4005                4010                4015    
Ala Leu Leu Cys Gln Leu Asn Ser
            4020                


<210> 6989
<211> 6669
<212> PRT
<213> Homo sapiens

<400> 6989
Met Ala Asp Asp Glu Asp Tyr Glu Glu Val Val Glu Tyr Tyr Thr Glu
 1               5                  10                  15      
Glu Val Val Tyr Glu Glu Val Pro Gly Glu Thr Ile Thr Lys Ile Tyr
            20                  25                  30          
Glu Thr Thr Thr Thr Arg Thr Ser Asp Tyr Glu Gln Ser Glu Thr Ser
        35                  40                  45              
Lys Pro Ala Leu Ala Gln Pro Ala Leu Ala Gln Pro Ala Ser Ala Lys
    50                  55                  60                  
Pro Val Glu Arg Arg Lys Val Ile Arg Lys Lys Val Asp Pro Ser Lys
65                  70                  75                  80  
Phe Met Thr Pro Tyr Ile Ala His Ser Gln Lys Met Gln Asp Leu Phe
                85                  90                  95      
Ser Pro Asn Lys Tyr Lys Glu Lys Phe Glu Lys Thr Lys Gly Gln Pro
            100                 105                 110         
Tyr Ala Ser Thr Thr Asp Thr Pro Glu Leu Arg Arg Ile Lys Lys Val
        115                 120                 125             
Gln Asp Gln Leu Ser Glu Val Lys Tyr Arg Met Asp Gly Asp Val Ala
    130                 135                 140                 
Lys Thr Ile Cys His Val Asp Glu Lys Ala Lys Asp Ile Glu His Ala
145                 150                 155                 160 
Lys Lys Val Ser Gln Gln Val Ser Lys Val Leu Tyr Lys Gln Asn Trp
                165                 170                 175     
Glu Asp Thr Lys Asp Lys Tyr Leu Leu Pro Pro Asp Ala Pro Glu Leu
            180                 185                 190         
Val Gln Ala Val Lys Asn Thr Ala Met Phe Ser Lys Lys Leu Tyr Thr
        195                 200                 205             
Glu Asp Trp Glu Ala Asp Lys Ser Leu Phe Tyr Pro Tyr Asn Asp Ser
    210                 215                 220                 
Pro Glu Leu Arg Arg Val Ala Gln Ala Gln Lys Ala Leu Ser Asp Val
225                 230                 235                 240 
Ala Tyr Lys Lys Gly Leu Ala Glu Gln Gln Ala Gln Phe Thr Pro Leu
                245                 250                 255     
Ala Asp Pro Pro Asp Ile Glu Phe Ala Lys Lys Val Thr Asn Gln Val
            260                 265                 270         
Ser Lys Gln Lys Tyr Lys Glu Asp Tyr Glu Asn Lys Ile Lys Gly Lys
        275                 280                 285             
Trp Ser Glu Thr Pro Cys Phe Glu Val Ala Asn Ala Arg Met Asn Ala
    290                 295                 300                 
Asp Asn Ile Ser Thr Arg Lys Tyr Gln Glu Asp Phe Glu Asn Met Lys
305                 310                 315                 320 
Asp Gln Ile Tyr Phe Met Gln Thr Glu Thr Pro Glu Tyr Lys Met Asn
                325                 330                 335     
Lys Lys Ala Gly Val Ala Ala Ser Lys Val Lys Tyr Lys Glu Asp Tyr
            340                 345                 350         
Glu Lys Asn Lys Gly Lys Ala Asp Tyr Asn Val Leu Pro Ala Ser Glu
        355                 360                 365             
Asn Pro Gln Leu Arg Gln Leu Lys Ala Ala Gly Asp Ala Leu Ser Asp
    370                 375                 380                 
Lys Leu Tyr Lys Glu Asn Tyr Glu Lys Thr Lys Ala Lys Ser Ile Asn
385                 390                 395                 400 
Tyr Cys Glu Thr Pro Lys Phe Lys Leu Asp Thr Val Leu Gln Asn Phe
                405                 410                 415     
Ser Ser Asp Lys Lys Tyr Lys Asp Ser Tyr Leu Lys Asp Ile Leu Gly
            420                 425                 430         
His Tyr Val Gly Ser Phe Glu Asp Pro Tyr His Ser His Cys Met Lys
        435                 440                 445             
Val Thr Ala Gln Asn Ser Asp Lys Asn Tyr Lys Ala Glu Tyr Glu Glu
    450                 455                 460                 
Asp Arg Gly Lys Gly Phe Phe Pro Gln Thr Ile Thr Gln Glu Tyr Glu
465                 470                 475                 480 
Ala Ile Lys Lys Leu Asp Gln Cys Lys Asp His Thr Tyr Lys Val His
                485                 490                 495     
Pro Asp Lys Thr Lys Phe Thr Gln Val Thr Asp Ser Pro Val Leu Leu
            500                 505                 510         
Gln Ala Gln Val Asn Ser Lys Gln Leu Ser Asp Leu Asn Tyr Lys Ala
        515                 520                 525             
Lys His Glu Ser Glu Lys Phe Lys Cys His Ile Pro Pro Asp Thr Pro
    530                 535                 540                 
Ala Phe Ile Gln His Lys Val Asn Ala Tyr Asn Leu Ser Asp Asn Leu
545                 550                 555                 560 
Tyr Lys Gln Asp Trp Glu Lys Ser Lys Ala Lys Lys Phe Asp Ile Lys
                565                 570                 575     
Val Asp Ala Ile Pro Leu Leu Ala Ala Lys Ala Asn Thr Lys Asn Thr
            580                 585                 590         
Ser Asp Val Met Tyr Lys Lys Asp Tyr Glu Lys Asn Lys Gly Lys Met
        595                 600                 605             
Ile Gly Val Leu Ser Ile Asn Asp Asp Pro Lys Met Leu His Ser Leu
    610                 615                 620                 
Lys Val Ala Lys Asn Gln Ser Asp Arg Leu Tyr Lys Glu Asn Tyr Glu
625                 630                 635                 640 
Lys Thr Lys Ala Lys Ser Met Asn Tyr Cys Glu Thr Pro Lys Tyr Gln
                645                 650                 655     
Leu Asp Thr Gln Leu Lys Asn Phe Ser Glu Ala Arg Tyr Lys Asp Leu
            660                 665                 670         
Tyr Val Lys Asp Val Leu Gly His Tyr Val Gly Ser Met Glu Asp Pro
        675                 680                 685             
Tyr His Thr His Cys Met Lys Val Ala Ala Gln Asn Ser Asp Lys Ser
    690                 695                 700                 
Tyr Lys Ala Glu Tyr Glu Glu Asp Lys Gly Lys Cys Tyr Phe Pro Gln
705                 710                 715                 720 
Thr Ile Thr Gln Glu Tyr Asp Ala Ile Lys Lys Leu Asp Gln Cys Lys
                725                 730                 735     
Asp His Thr Tyr Lys Val His Pro Asp Lys Thr Lys Phe Thr Ala Val
            740                 745                 750         
Thr Asp Ser Pro Val Leu Leu Gln Ala Gln Leu Asn Thr Lys Gln Leu
        755                 760                 765             
Ser Asp Leu Asn Tyr Lys Ala Lys His Glu Gly Glu Arg Phe Lys Cys
    770                 775                 780                 
His Ile Pro Ala Asp Ala Pro Gln Phe Ile Gln His Arg Val Asn Ala
785                 790                 795                 800 
Tyr Asn Leu Ser Asp Asn Val Tyr Lys Gln Asp Trp Glu Lys Ser Lys
                805                 810                 815     
Ala Lys Lys Phe Asp Ile Lys Val Asp Ala Ile Pro Leu Leu Ala Ala
            820                 825                 830         
Lys Ala Asn Thr Lys Asn Thr Ser Asp Val Met Tyr Lys Lys Asp Tyr
        835                 840                 845             
Glu Lys Ser Lys Gly Lys Met Ile Gly Ala Leu Ser Ile Asn Asp Asp
    850                 855                 860                 
Pro Lys Met Leu His Ser Leu Lys Thr Ala Lys Asn Gln Ser Asp Arg
865                 870                 875                 880 
Glu Tyr Arg Lys Asp Tyr Glu Lys Ser Lys Thr Ile Tyr Thr Ala Pro
                885                 890                 895     
Leu Asp Met Leu Gln Val Thr Gln Ala Lys Lys Ser Gln Ala Ile Ala
            900                 905                 910         
Ser Asp Val Asp Tyr Lys His Ile Leu His Ser Tyr Ser Tyr Pro Pro
        915                 920                 925             
Asp Ser Ile Asn Val Asp Leu Ala Lys Lys Ala Tyr Ala Leu Gln Ser
    930                 935                 940                 
Asp Val Glu Tyr Lys Ala Asp Tyr Asn Ser Trp Met Lys Gly Cys Gly
945                 950                 955                 960 
Trp Val Pro Phe Gly Ser Leu Glu Met Glu Lys Ala Lys Arg Ala Ser
                965                 970                 975     
Asp Ile Leu Asn Glu Lys Lys Tyr Arg Gln His Pro Asp Thr Leu Lys
            980                 985                 990         
Phe Thr Ser Ile Glu Asp Ala Pro Ile Thr Val Gln Ser Lys Ile Asn
        995                 1000                1005            
Gln Ala Gln Arg Ser Asp Ile Ala Tyr Lys Ala Lys Gly Glu Glu Ile
    1010                1015                1020                
Ile His Asn Tyr Asn Leu Pro Pro Asp Leu Pro Gln Phe Ile Gln Ala
1025                1030                1035                1040
Lys Val Asn Ala Tyr Asn Ile Ser Glu Asn Met Tyr Lys Ala Asp Leu
                1045                1050                1055    
Lys Asp Leu Ser Lys Lys Gly Tyr Asp Leu Arg Thr Asp Ala Ile Pro
            1060                1065                1070        
Ile Arg Ala Ala Lys Ala Ala Arg Gln Ala Ala Ser Asp Val Gln Tyr
        1075                1080                1085            
Lys Lys Asp Tyr Glu Lys Ala Lys Gly Lys Met Val Gly Phe Gln Ser
    1090                1095                1100                
Leu Gln Asp Asp Pro Lys Leu Val His Tyr Met Asn Val Ala Lys Ile
1105                1110                1115                1120
Gln Ser Asp Arg Glu Tyr Lys Lys Asp Tyr Glu Lys Thr Lys Ser Lys
                1125                1130                1135    
Tyr Asn Thr Pro His Asp Met Phe Asn Val Val Ala Ala Lys Lys Ala
            1140                1145                1150        
Gln Asp Val Val Ser Asn Val Asn Tyr Lys His Ser Leu His His Tyr
        1155                1160                1165            
Thr Tyr Leu Pro Asp Ala Met Asp Leu Glu Leu Ser Lys Asn Met Met
    1170                1175                1180                
Gln Ile Gln Ser Asp Asn Val Tyr Lys Glu Asp Tyr Asn Asn Trp Met
1185                1190                1195                1200
Lys Gly Ile Gly Trp Ile Pro Ile Gly Ser Leu Asp Val Glu Lys Val
                1205                1210                1215    
Lys Lys Ala Gly Asp Ala Leu Asn Glu Lys Lys Tyr Arg Gln His Pro
            1220                1225                1230        
Asp Thr Leu Lys Phe Thr Ser Ile Val Asp Ser Pro Val Met Val Gln
        1235                1240                1245            
Ala Lys Gln Asn Thr Lys Gln Val Ser Asp Ile Leu Tyr Lys Ala Lys
    1250                1255                1260                
Gly Glu Asp Val Lys His Lys Tyr Thr Met Ser Pro Asp Leu Pro Gln
1265                1270                1275                1280
Phe Leu Gln Ala Lys Cys Asn Ala Tyr Ser Ile Ser Asp Val Cys Tyr
                1285                1290                1295    
Lys Arg Asp Trp His Asp Leu Ile Arg Lys Gly Asn Asn Val Leu Gly
            1300                1305                1310        
Asp Ala Ile Pro Ile Thr Ala Ala Lys Ala Ser Arg Asn Ile Ala Ser
        1315                1320                1325            
Asp Tyr Lys Tyr Lys Glu Ala Tyr Glu Lys Ser Lys Gly Lys His Val
    1330                1335                1340                
Gly Phe Arg Ser Leu Gln Asp Asp Pro Lys Leu Val His Tyr Met Asn
1345                1350                1355                1360
Val Ala Lys Leu Gln Ser Asp Arg Glu Tyr Lys Lys Asn Tyr Glu Asn
                1365                1370                1375    
Thr Lys Thr Ser Tyr His Thr Pro Gly Asp Met Val Thr Ile Thr Ala
            1380                1385                1390        
Ala Lys Met Ala Gln Asp Val Ala Thr Asn Val Asn Tyr Lys Gln Pro
        1395                1400                1405            
Leu His His Tyr Thr Tyr Leu Pro Asp Ala Met Ser Leu Glu His Thr
    1410                1415                1420                
Arg Asn Val Asn Gln Ile Gln Ser Asp Asn Val Tyr Lys Asp Glu Tyr
1425                1430                1435                1440
Asn Ser Phe Leu Lys Gly Ile Gly Trp Ile Pro Ile Gly Ser Leu Glu
                1445                1450                1455    
Val Glu Lys Val Lys Lys Ala Gly Asp Ala Leu Asn Glu Arg Lys Tyr
            1460                1465                1470        
Arg Gln His Pro Asp Thr Val Lys Phe Thr Ser Val Pro Asp Ser Met
        1475                1480                1485            
Gly Met Met Leu Ala Gln His Asn Thr Lys Gln Leu Ser Asp Leu Asn
    1490                1495                1500                
Tyr Lys Val Glu Gly Glu Lys Leu Lys His Lys Tyr Thr Ile Asp Pro
1505                1510                1515                1520
Glu Leu Pro Gln Phe Ile Gln Ala Lys Val Asn Ala Leu Asn Met Ser
                1525                1530                1535    
Asp Ala His Tyr Lys Ala Asp Trp Lys Lys Thr Ile Arg Lys Gly Tyr
            1540                1545                1550        
Asp Leu Arg Pro Asp Ala Ile Pro Ile Val Ala Ala Lys Ser Ser Arg
        1555                1560                1565            
Asn Ile Ala Ser Asp Cys Lys Tyr Lys Glu Ala Tyr Glu Lys Ala Lys
    1570                1575                1580                
Gly Lys Gln Val Gly Phe Leu Ser Leu Gln Asp Asp Pro Lys Leu Val
1585                1590                1595                1600
His Tyr Met Asn Val Ala Lys Ile Gln Ser Asp Arg Glu Tyr Lys Lys
                1605                1610                1615    
Gly Tyr Glu Ala Ser Lys Thr Lys Tyr His Thr Pro Leu Asp Met Val
            1620                1625                1630        
Ser Val Thr Ala Ala Lys Lys Ser Gln Glu Val Ala Thr Asn Ala Asn
        1635                1640                1645            
Tyr Arg Gln Ser Tyr His His Tyr Thr Leu Leu Pro Asp Ala Leu Asn
    1650                1655                1660                
Val Glu His Ser Arg Asn Ala Met Gln Ile Gln Ser Asp Asn Leu Tyr
1665                1670                1675                1680
Lys Ser Asp Phe Thr Asn Trp Met Lys Gly Ile Gly Trp Val Pro Ile
                1685                1690                1695    
Glu Ser Leu Glu Val Glu Lys Ala Lys Lys Ala Gly Glu Ile Leu Ser
            1700                1705                1710        
Glu Lys Lys Tyr Arg Gln His Pro Glu Lys Leu Lys Phe Thr Tyr Ala
        1715                1720                1725            
Met Asp Thr Met Glu Gln Ala Leu Asn Lys Ser Asn Lys Leu Asn Met
    1730                1735                1740                
Asp Lys Arg Leu Tyr Thr Glu Lys Trp Asn Lys Asp Lys Thr Thr Ile
1745                1750                1755                1760
His Val Met Pro Asp Thr Pro Asp Ile Leu Leu Ser Arg Val Asn Gln
                1765                1770                1775    
Ile Thr Met Ser Asp Lys Leu Tyr Lys Ala Gly Trp Glu Glu Glu Lys
            1780                1785                1790        
Lys Lys Gly Tyr Asp Leu Arg Pro Asp Ala Ile Ala Ile Lys Ala Ala
        1795                1800                1805            
Arg Ala Ser Arg Asp Ile Ala Ser Asp Tyr Lys Tyr Lys Lys Ala Tyr
    1810                1815                1820                
Glu Gln Ala Lys Gly Lys His Ile Gly Phe Arg Ser Leu Glu Asp Asp
1825                1830                1835                1840
Pro Lys Leu Val His Phe Met Gln Val Ala Lys Met Gln Ser Asp Arg
                1845                1850                1855    
Glu Tyr Lys Lys Gly Tyr Glu Lys Ser Lys Thr Ser Phe His Thr Pro
            1860                1865                1870        
Val Asp Met Leu Ser Val Val Ala Ala Lys Lys Ser Gln Glu Val Ala
        1875                1880                1885            
Thr Asn Ala Asn Tyr Arg Asn Val Ile His Thr Tyr Asn Met Leu Pro
    1890                1895                1900                
Asp Ala Met Ser Phe Glu Leu Ala Lys Asn Met Met Gln Ile Gln Ser
1905                1910                1915                1920
Asp Asn Gln Tyr Lys Ala Asp Tyr Ala Asp Phe Met Lys Gly Ile Gly
                1925                1930                1935    
Trp Leu Pro Leu Gly Ser Leu Glu Ala Glu Lys Asn Lys Lys Ala Met
            1940                1945                1950        
Glu Ile Ile Ser Glu Lys Lys Tyr Arg Gln His Pro Asp Thr Leu Lys
        1955                1960                1965            
Tyr Ser Thr Leu Met Asp Ser Met Asn Met Val Leu Ala Gln Asn Asn
    1970                1975                1980                
Ala Lys Ile Met Asn Glu His Leu Tyr Lys Gln Ala Trp Glu Ala Asp
1985                1990                1995                2000
Lys Thr Lys Val His Ile Met Pro Asp Ile Pro Gln Ile Ile Leu Ala
                2005                2010                2015    
Lys Ala Asn Ala Ile Asn Ile Ser Asp Lys Leu Tyr Lys Leu Ser Leu
            2020                2025                2030        
Glu Glu Ser Lys Lys Lys Gly Tyr Asp Leu Arg Pro Asp Ala Ile Pro
        2035                2040                2045            
Ile Lys Ala Ala Lys Ala Ser Arg Asp Ile Ala Ser Asp Tyr Lys Tyr
    2050                2055                2060                
Lys Tyr Asn Tyr Glu Lys Gly Lys Gly Lys Met Val Gly Phe Arg Ser
2065                2070                2075                2080
Leu Glu Asp Asp Pro Lys Leu Val His Ser Met Gln Val Ala Lys Met
                2085                2090                2095    
Gln Ser Asp Arg Glu Tyr Lys Lys Asn Tyr Glu Asn Thr Lys Thr Ser
            2100                2105                2110        
Tyr His Thr Pro Ala Asp Met Leu Ser Val Thr Ala Ala Lys Asp Ala
        2115                2120                2125            
Gln Ala Asn Ile Thr Asn Thr Asn Tyr Lys His Leu Ile His Lys Tyr
    2130                2135                2140                
Ile Leu Leu Pro Asp Ala Met Asn Ile Glu Leu Thr Arg Asn Met Asn
2145                2150                2155                2160
Arg Ile Gln Ser Asp Asn Glu Tyr Lys Gln Asp Tyr Asn Glu Trp Tyr
                2165                2170                2175    
Lys Gly Leu Gly Trp Ser Pro Ala Gly Ser Leu Glu Val Glu Lys Ala
            2180                2185                2190        
Lys Lys Ala Thr Glu Tyr Ala Ser Asp Gln Lys Tyr Arg Gln His Pro
        2195                2200                2205            
Ser Asn Phe Gln Phe Lys Lys Leu Thr Asp Ser Met Asp Met Val Leu
    2210                2215                2220                
Ala Lys Gln Asn Ala His Thr Met Asn Lys His Leu Tyr Thr Ile Asp
2225                2230                2235                2240
Trp Asn Lys Asp Lys Thr Lys Ile His Val Met Pro Asp Thr Pro Asp
                2245                2250                2255    
Ile Leu Gln Ala Lys Gln Asn Gln Thr Leu Tyr Ser Gln Lys Leu Tyr
            2260                2265                2270        
Lys Leu Gly Trp Glu Glu Ala Leu Lys Lys Gly Tyr Asp Leu Pro Val
        2275                2280                2285            
Asp Ala Ile Ser Val Gln Leu Ala Lys Ala Ser Arg Asp Ile Ala Ser
    2290                2295                2300                
Asp Tyr Lys Tyr Lys Gln Gly Tyr Arg Lys Gln Leu Gly His His Val
2305                2310                2315                2320
Gly Phe Arg Ser Leu Gln Asp Asp Pro Lys Leu Val Leu Ser Met Asn
                2325                2330                2335    
Val Ala Lys Met Gln Ser Glu Arg Glu Tyr Lys Lys Asp Phe Glu Lys
            2340                2345                2350        
Trp Lys Thr Lys Phe Ser Ser Pro Val Asp Met Leu Gly Val Val Leu
        2355                2360                2365            
Ala Lys Lys Cys Gln Glu Leu Val Ser Asp Val Asp Tyr Lys Asn Tyr
    2370                2375                2380                
Leu His Gln Trp Thr Cys Leu Pro Asp Gln Asn Asp Val Val Gln Ala
2385                2390                2395                2400
Lys Lys Val Tyr Glu Leu Gln Ser Glu Asn Leu Tyr Lys Ser Asp Leu
                2405                2410                2415    
Glu Trp Leu Arg Gly Ile Gly Trp Ser Pro Leu Gly Ser Leu Glu Ala
            2420                2425                2430        
Glu Lys Asn Lys Arg Ala Ser Glu Ile Ile Ser Glu Lys Lys Tyr Arg
        2435                2440                2445            
Gln Pro Pro Asp Arg Asn Lys Phe Thr Ser Ile Pro Asp Ala Met Asp
    2450                2455                2460                
Ile Val Leu Ala Lys Thr Asn Ala Lys Asn Arg Ser Asp Arg Leu Tyr
2465                2470                2475                2480
Arg Glu Ala Trp Asp Lys Asp Lys Thr Gln Ile His Ile Met Pro Asp
                2485                2490                2495    
Thr Pro Asp Ile Val Leu Ala Lys Ala Asn Leu Ile Asn Thr Ser Asp
            2500                2505                2510        
Lys Leu Tyr Arg Met Gly Tyr Glu Glu Leu Lys Arg Lys Gly Tyr Asp
        2515                2520                2525            
Leu Pro Val Asp Ala Ile Pro Ile Lys Ala Ala Lys Ala Ser Arg Glu
    2530                2535                2540                
Ile Ala Ser Glu Tyr Lys Tyr Lys Glu Gly Phe Arg Lys Gln Leu Gly
2545                2550                2555                2560
His His Ile Gly Ala Arg Asn Ile Glu Asp Asp Pro Lys Met Met Trp
                2565                2570                2575    
Ser Met His Val Ala Lys Ile Gln Ser Asp Arg Glu Tyr Lys Lys Asp
            2580                2585                2590        
Phe Glu Lys Trp Lys Thr Lys Phe Ser Ser Pro Val Asp Met Leu Gly
        2595                2600                2605            
Val Val Leu Ala Tyr Lys Cys Gln Thr Leu Val Ser Asp Val Asp Tyr
    2610                2615                2620                
Lys Asn Tyr Leu His Gln Trp Thr Cys Leu Pro Asp Gln Ser Asp Val
2625                2630                2635                2640
Ile His Ala Arg Gln Ala Tyr Asp Leu Gln Ser Asp Asn Leu Tyr Lys
                2645                2650                2655    
Ser Asp Leu Gln Trp Leu Lys Gly Ile Gly Trp Met Thr Ser Gly Ser
            2660                2665                2670        
Leu Glu Asp Glu Lys Asn Lys Arg Ala Thr Gln Ile Leu Ser Asp His
        2675                2680                2685            
Val Tyr Arg Gln His Pro Asp Gln Phe Lys Phe Ser Ser Leu Met Asp
    2690                2695                2700                
Ser Ile Pro Met Val Leu Ala Lys Asn Asn Ala Ile Thr Met Asn His
2705                2710                2715                2720
Arg Leu Tyr Thr Glu Ala Trp Asp Lys Asp Lys Thr Thr Val His Ile
                2725                2730                2735    
Met Pro Asp Thr Pro Glu Val Leu Leu Ala Lys Gln Asn Lys Val Asn
            2740                2745                2750        
Tyr Ser Glu Lys Leu Tyr Lys Leu Gly Leu Glu Glu Ala Lys Arg Lys
        2755                2760                2765            
Gly Tyr Asp Met Arg Val Asp Ala Ile Pro Ile Lys Ala Ala Lys Ala
    2770                2775                2780                
Ser Arg Asp Ile Ala Ser Glu Phe Lys Tyr Lys Glu Gly Tyr Arg Lys
2785                2790                2795                2800
Gln Leu Gly His His Ile Gly Ala Arg Ala Ile Arg Asp Asp Pro Lys
                2805                2810                2815    
Met Met Trp Ser Met His Val Ala Lys Ile Gln Ser Asp Arg Glu Tyr
            2820                2825                2830        
Lys Lys Asp Phe Glu Lys Trp Lys Thr Lys Phe Ser Ser Pro Val Asp
        2835                2840                2845            
Met Leu Gly Val Val Leu Ala Lys Lys Cys Gln Thr Leu Val Ser Asp
    2850                2855                2860                
Val Asp Tyr Lys Asn Tyr Leu His Gln Trp Thr Cys Leu Pro Asp Gln
2865                2870                2875                2880
Ser Asp Val Ile His Ala Arg Gln Ala Tyr Asp Leu Gln Ser Asp Asn
                2885                2890                2895    
Met Tyr Lys Ser Asp Leu Gln Trp Met Arg Gly Ile Gly Trp Val Ser
            2900                2905                2910        
Ile Gly Ser Leu Asp Val Glu Lys Cys Lys Arg Ala Thr Glu Ile Leu
        2915                2920                2925            
Ser Asp Lys Ile Tyr Arg Gln Pro Pro Asp Arg Phe Lys Phe Thr Ser
    2930                2935                2940                
Val Thr Asp Ser Leu Glu Gln Val Leu Ala Lys Asn Asn Ala Leu Asn
2945                2950                2955                2960
Met Asn Lys Arg Leu Tyr Thr Glu Ala Trp Asp Lys Asp Lys Thr Gln
                2965                2970                2975    
Ile His Ile Met Pro Asp Thr Pro Glu Ile Met Leu Ala Arg Gln Asn
            2980                2985                2990        
Lys Ile Asn Tyr Ser Glu Thr Leu Tyr Lys Leu Ala Asn Glu Glu Ala
        2995                3000                3005            
Lys Lys Lys Gly Tyr Asp Leu Arg Ser Asp Ala Ile Pro Ile Val Ala
    3010                3015                3020                
Ala Lys Ala Ser Arg Asp Val Ile Ser Asp Tyr Lys Tyr Lys Asp Gly
3025                3030                3035                3040
Tyr Arg Lys Gln Leu Gly His His Ile Gly Ala Arg Asn Ile Glu Asp
                3045                3050                3055    
Asp Pro Lys Met Met Trp Ser Met His Val Ala Lys Ile Gln Ser Asp
            3060                3065                3070        
Arg Glu Tyr Lys Lys Asp Phe Glu Lys Trp Lys Thr Lys Phe Ser Ser
        3075                3080                3085            
Pro Val Asp Met Leu Gly Val Val Leu Ala Lys Lys Cys Gln Thr Leu
    3090                3095                3100                
Val Ser Asp Val Asp Tyr Lys Asn Tyr Leu His Glu Trp Thr Cys Leu
3105                3110                3115                3120
Pro Asp Gln Asn Asp Val Ile His Ala Arg Gln Ala Tyr Asp Leu Gln
                3125                3130                3135    
Ser Asp Asn Ile Tyr Lys Ser Asp Leu Gln Trp Leu Arg Gly Ile Gly
            3140                3145                3150        
Trp Val Pro Ile Gly Ser Met Asp Val Val Lys Cys Lys Arg Ala Ala
        3155                3160                3165            
Glu Ile Leu Ser Asp Asn Ile Tyr Arg Gln Pro Pro Asp Lys Leu Lys
    3170                3175                3180                
Phe Thr Ser Val Thr Asp Ser Leu Glu Gln Val Leu Ala Lys Asn Asn
3185                3190                3195                3200
Ala Leu Asn Met Asn Lys Arg Leu Tyr Thr Glu Ala Trp Asp Lys Asp
                3205                3210                3215    
Lys Thr Gln Val His Ile Met Pro Asp Thr Pro Glu Ile Met Leu Ala
            3220                3225                3230        
Arg Gln Asn Lys Ile Asn Tyr Ser Glu Ser Leu Tyr Arg Gln Ala Met
        3235                3240                3245            
Glu Glu Ala Lys Lys Glu Gly Tyr Asp Leu Arg Ser Asp Ala Ile Pro
    3250                3255                3260                
Ile Val Ala Ala Lys Ala Ser Arg Asp Ile Ala Ser Asp Tyr Lys Tyr
3265                3270                3275                3280
Lys Glu Ala Tyr Arg Lys Gln Leu Gly His His Ile Gly Ala Arg Ala
                3285                3290                3295    
Val His Asp Asp Pro Lys Ile Met Trp Ser Leu His Ile Ala Lys Val
            3300                3305                3310        
Gln Ser Asp Arg Glu Tyr Lys Lys Asp Phe Glu Lys Tyr Lys Thr Arg
        3315                3320                3325            
Tyr Ser Ser Pro Val Asp Met Leu Gly Ile Val Leu Ala Lys Lys Cys
    3330                3335                3340                
Gln Thr Leu Val Ser Asp Val Asp Tyr Lys His Pro Leu His Glu Cys
3345                3350                3355                3360
Ile Cys Leu Pro Asp Gln Asn Asp Ile Ile His Ala Arg Lys Ala Tyr
                3365                3370                3375    
Asp Leu Gln Ser Asp Asn Leu Tyr Lys Ser Asp Leu Glu Trp Met Lys
            3380                3385                3390        
Gly Ile Gly Trp Val Pro Ile Asp Ser Leu Glu Val Val Arg Ala Lys
        3395                3400                3405            
Arg Ala Gly Glu Leu Leu Ser Asp Thr Ile Tyr Arg Gln Arg Pro Glu
    3410                3415                3420                
Thr Leu Lys Phe Thr Ser Ile Thr Asp Thr Pro Glu Gln Val Leu Ala
3425                3430                3435                3440
Lys Asn Asn Ala Leu Asn Met Asn Lys Arg Leu Tyr Thr Glu Ala Trp
                3445                3450                3455    
Asp Asn Asp Lys Lys Thr Ile His Val Met Pro Asp Thr Pro Glu Ile
            3460                3465                3470        
Met Leu Ala Lys Leu Asn Arg Ile Asn Tyr Ser Asp Lys Leu Tyr Lys
        3475                3480                3485            
Leu Ala Leu Glu Glu Ser Lys Lys Glu Gly Tyr Asp Leu Arg Leu Asp
    3490                3495                3500                
Ala Ile Pro Ile Gln Ala Ala Lys Ala Ser Arg Asp Ile Ala Ser Asp
3505                3510                3515                3520
Tyr Lys Tyr Lys Glu Gly Tyr Arg Lys Gln Leu Gly His His Ile Gly
                3525                3530                3535    
Ala Arg Asn Ile Lys Asp Asp Pro Lys Met Met Trp Ser Ile His Val
            3540                3545                3550        
Ala Lys Ile Gln Ser Asp Arg Glu Tyr Lys Lys Glu Phe Glu Lys Trp
        3555                3560                3565            
Lys Thr Lys Phe Ser Ser Pro Val Asp Met Leu Gly Val Val Leu Ala
    3570                3575                3580                
Lys Lys Cys Gln Ile Leu Val Ser Asp Ile Asp Tyr Lys His Pro Leu
3585                3590                3595                3600
His Glu Trp Thr Cys Leu Pro Asp Gln Asn Asp Val Ile Gln Ala Arg
                3605                3610                3615    
Lys Ala Tyr Asp Leu Gln Ser Asp Ala Ile Tyr Lys Ser Asp Leu Glu
            3620                3625                3630        
Trp Leu Arg Gly Ile Gly Trp Val Pro Ile Gly Ser Val Glu Val Glu
        3635                3640                3645            
Lys Val Lys Arg Ala Gly Glu Ile Leu Ser Asp Arg Lys Tyr Arg Gln
    3650                3655                3660                
Pro Ala Asp Gln Leu Lys Phe Thr Cys Ile Thr Asp Thr Pro Glu Ile
3665                3670                3675                3680
Val Leu Ala Lys Asn Asn Ala Leu Thr Met Ser Lys His Leu Tyr Thr
                3685                3690                3695    
Glu Ala Trp Asp Ala Asp Lys Thr Ser Ile His Val Met Pro Asp Thr
            3700                3705                3710        
Pro Asp Ile Leu Leu Ala Lys Ser Asn Ser Ala Asn Ile Ser Gln Lys
        3715                3720                3725            
Leu Tyr Thr Lys Gly Trp Asp Glu Ser Lys Met Lys Asp Tyr Asp Leu
    3730                3735                3740                
Arg Ala Asp Ala Ile Ser Ile Lys Ser Ala Lys Ala Ser Arg Asp Ile
3745                3750                3755                3760
Ala Ser Asp Tyr Lys Tyr Lys Glu Ala Tyr Glu Lys Gln Lys Gly His
                3765                3770                3775    
His Ile Gly Ala Gln Ser Ile Glu Asp Asp Pro Lys Ile Met Cys Ala
            3780                3785                3790        
Ile His Ala Glu Lys Ile Gln Ser Glu Arg Glu Tyr Lys Lys Glu Phe
        3795                3800                3805            
Gln Lys Trp Lys Thr Lys Phe Ser Ser Pro Val Asp Met Leu Ser Ile
    3810                3815                3820                
Leu Leu Ala Lys Lys Cys Gln Thr Leu Val Thr Asp Ile Tyr Tyr Arg
3825                3830                3835                3840
Asn Tyr Leu His Glu Trp Thr Cys Met Pro Asp Gln Asn Asp Ile Ile
                3845                3850                3855    
Gln Ala Lys Lys Ala Tyr Asp Leu Gln Ser Asp Ala Leu Tyr Lys Ala
            3860                3865                3870        
Asp Leu Glu Trp Leu Arg Gly Ile Gly Trp Met Pro Gln Gly Ser Pro
        3875                3880                3885            
Glu Val Leu Arg Val Lys Asn Ala Gln Asn Ile Phe Cys Asp Ser Val
    3890                3895                3900                
Tyr Arg Thr Pro Val Val Asn Leu Lys Tyr Thr Ser Ile Val Asp Thr
3905                3910                3915                3920
Pro Glu Val Val Leu Ala Lys Ser Asn Ala Glu Asn Ile Ser Ile Pro
                3925                3930                3935    
Lys Tyr Arg Glu Val Trp Asp Lys Asp Lys Thr Ser Ile His Ile Met
            3940                3945                3950        
Pro Asp Thr Pro Glu Ile Asn Leu Ala Arg Ala Asn Ala Leu Asn Val
        3955                3960                3965            
Ser Asn Lys Leu Tyr Arg Glu Gly Trp Asp Glu Met Lys Ala Gly Cys
    3970                3975                3980                
Asp Val Arg Leu Asp Ala Ile Pro Ile Gln Ala Ala Lys Ala Ser Arg
3985                3990                3995                4000
Glu Ile Ala Ser Asp Tyr Lys Tyr Lys Leu Asp His Glu Lys Gln Lys
                4005                4010                4015    
Gly His Tyr Val Gly Thr Leu Thr Ala Arg Asp Asp Asn Lys Ile Arg
            4020                4025                4030        
Trp Ala Leu Ile Ala Asp Lys Leu Gln Asn Glu Arg Glu Tyr Arg Leu
        4035                4040                4045            
Asp Trp Ala Lys Trp Lys Ala Lys Ile Gln Ser Pro Val Asp Met Leu
    4050                4055                4060                
Ser Ile Leu His Ser Lys Asn Ser Gln Ala Leu Val Ser Asp Met Asp
4065                4070                4075                4080
Tyr Arg Asn Tyr Leu His Gln Trp Thr Cys Met Pro Asp Gln Asn Asp
                4085                4090                4095    
Val Ile Gln Ala Lys Lys Ala Tyr Glu Leu Gln Ser Asp Asn Val Tyr
            4100                4105                4110        
Lys Ala Asp Leu Glu Trp Leu Arg Gly Ile Gly Trp Met Pro Asn Asp
        4115                4120                4125            
Ser Val Ser Val Asn His Ala Lys His Ala Ala Asp Ile Phe Ser Glu
    4130                4135                4140                
Lys Lys Tyr Arg Thr Lys Ile Glu Thr Leu Asn Phe Thr Pro Val Asp
4145                4150                4155                4160
Asp Arg Val Asp Tyr Val Thr Ala Lys Gln Ser Gly Glu Ile Leu Asp
                4165                4170                4175    
Asp Ile Lys Tyr Arg Lys Asp Trp Asn Ala Thr Lys Ser Lys Tyr Thr
            4180                4185                4190        
Leu Thr Glu Thr Pro Leu Leu His Thr Ala Gln Glu Ala Ala Arg Ile
        4195                4200                4205            
Leu Asp Gln Tyr Leu Tyr Lys Glu Gly Trp Glu Arg Gln Lys Ala Thr
    4210                4215                4220                
Gly Tyr Ile Leu Pro Pro Asp Ala Val Pro Phe Val His Ala His His
4225                4230                4235                4240
Cys Asn Asp Val Gln Ser Glu Leu Lys Tyr Lys Ala Glu His Val Lys
                4245                4250                4255    
Gln Lys Gly His Tyr Val Gly Val Pro Thr Met Arg Asp Asp Pro Lys
            4260                4265                4270        
Leu Val Trp Phe Glu His Ala Gly Gln Ile Gln Asn Glu Arg Leu Tyr
        4275                4280                4285            
Lys Glu Asp Tyr His Lys Thr Lys Ala Lys Ile Asn Ile Pro Ala Asp
    4290                4295                4300                
Met Val Ser Val Leu Ala Ala Lys Gln Gly Gln Thr Leu Val Ser Asp
4305                4310                4315                4320
Ile Asp Tyr Arg Asn Tyr Leu His Gln Trp Met Cys His Pro Asp Gln
                4325                4330                4335    
Asn Asp Val Ile Gln Ala Arg Lys Ala Tyr Asp Leu Gln Ser Asp Asn
            4340                4345                4350        
Val Tyr Arg Ala Asp Leu Glu Trp Leu Arg Gly Ile Gly Trp Ile Pro
        4355                4360                4365            
Leu Asp Ser Val Asp His Val Arg Val Thr Lys Asn Gln Glu Met Met
    4370                4375                4380                
Ser Gln Ile Lys Tyr Lys Lys Asn Ala Leu Glu Asn Tyr Pro Asn Phe
4385                4390                4395                4400
Thr Ser Val Val Asp Pro Pro Glu Ile Val Leu Ala Lys Ile Asn Ser
                4405                4410                4415    
Val Asn Gln Ser Asp Val Lys Tyr Lys Glu Thr Phe Asn Lys Ala Lys
            4420                4425                4430        
Gly Lys Tyr Thr Phe Ser Pro Asp Thr Pro His Ile Ser His Ser Lys
        4435                4440                4445            
Asp Met Gly Lys Leu Tyr Ser Thr Ile Leu Tyr Lys Gly Ala Trp Glu
    4450                4455                4460                
Gly Thr Lys Ala Tyr Gly Tyr Thr Leu Asp Glu Arg Tyr Ile Pro Ile
4465                4470                4475                4480
Val Gly Ala Lys His Ala Asp Leu Val Asn Ser Glu Leu Lys Tyr Lys
                4485                4490                4495    
Glu Thr Tyr Glu Lys Gln Lys Gly His Tyr Leu Ala Gly Lys Val Ile
            4500                4505                4510        
Gly Glu Phe Pro Gly Val Val His Cys Leu Asp Phe Gln Lys Met Arg
        4515                4520                4525            
Ser Ala Leu Asn Tyr Arg Lys His Tyr Glu Asp Thr Lys Ala Asn Val
    4530                4535                4540                
His Ile Pro Asn Asp Met Met Asn His Val Leu Ala Lys Arg Cys Gln
4545                4550                4555                4560
Tyr Ile Leu Ser Asp Leu Glu Tyr Arg His Tyr Phe His Gln Trp Thr
                4565                4570                4575    
Ser Leu Leu Glu Glu Pro Asn Val Ile Arg Val Arg Asn Ala Gln Glu
            4580                4585                4590        
Ile Leu Ser Asp Asn Val Tyr Lys Asp Asp Leu Asn Trp Leu Lys Gly
        4595                4600                4605            
Ile Gly Cys Tyr Val Trp Asp Thr Pro Gln Ile Leu His Ala Lys Lys
    4610                4615                4620                
Ser Tyr Asp Leu Gln Ser Gln Leu Gln Tyr Thr Ala Ala Gly Lys Glu
4625                4630                4635                4640
Asn Leu Gln Asn Tyr Asn Leu Val Thr Asp Thr Pro Leu Tyr Val Thr
                4645                4650                4655    
Ala Val Gln Ser Gly Ile Asn Ala Ser Glu Val Lys Tyr Lys Glu Asn
            4660                4665                4670        
Tyr His Gln Ile Lys Asp Lys Tyr Thr Thr Val Leu Glu Thr Val Asp
        4675                4680                4685            
Tyr Asp Arg Thr Arg Asn Leu Lys Asn Leu Tyr Ser Ser Asn Leu Tyr
    4690                4695                4700                
Lys Glu Ala Trp Asp Arg Val Lys Ala Thr Ser Tyr Ile Leu Pro Ser
4705                4710                4715                4720
Ser Thr Leu Ser Leu Thr His Ala Lys Asn Gln Lys His Leu Ala Ser
                4725                4730                4735    
His Ile Lys Tyr Arg Glu Glu Tyr Glu Lys Phe Lys Ala Leu Tyr Thr
            4740                4745                4750        
Leu Pro Arg Ser Val Asp Asp Asp Pro Asn Thr Ala Arg Cys Leu Arg
        4755                4760                4765            
Val Gly Lys Leu Asn Ile Asp Arg Leu Tyr Arg Ser Val Tyr Glu Lys
    4770                4775                4780                
Asn Lys Met Lys Ile His Ile Val Pro Asp Met Val Glu Met Val Thr
4785                4790                4795                4800
Ala Lys Asp Ser Gln Lys Lys Val Ser Glu Ile Asp Tyr Arg Leu Arg
                4805                4810                4815    
Leu His Glu Trp Ile Cys His Pro Asp Leu Gln Val Asn Asp His Val
            4820                4825                4830        
Arg Lys Val Thr Asp Gln Ile Ser Asp Ile Val Tyr Lys Asp Asp Leu
        4835                4840                4845            
Asn Trp Leu Lys Gly Ile Gly Cys Tyr Val Trp Asp Thr Pro Glu Ile
    4850                4855                4860                
Leu His Ala Lys His Ala Tyr Asp Leu Arg Asp Asp Ile Lys Tyr Lys
4865                4870                4875                4880
Ala His Met Leu Lys Thr Arg Asn Asp Tyr Lys Leu Val Thr Asp Thr
                4885                4890                4895    
Pro Val Tyr Val Gln Ala Val Lys Ser Gly Lys Gln Leu Ser Asp Ala
            4900                4905                4910        
Val Tyr His Tyr Asp Tyr Val His Ser Val Arg Gly Lys Val Ala Pro
        4915                4920                4925            
Thr Thr Lys Thr Val Asp Leu Asp Arg Ala Leu His Ala Tyr Lys Leu
    4930                4935                4940                
Gln Ser Ser Asn Leu Tyr Lys Thr Ser Leu Arg Thr Leu Pro Thr Gly
4945                4950                4955                4960
Tyr Arg Leu Pro Gly Asp Thr Pro His Phe Lys His Ile Lys Asp Thr
                4965                4970                4975    
Arg Tyr Met Ser Ser Tyr Phe Lys Tyr Lys Glu Ala Tyr Glu His Thr
            4980                4985                4990        
Lys Ala Tyr Gly Tyr Thr Leu Gly Pro Lys Asp Val Pro Phe Val His
        4995                5000                5005            
Val Arg Arg Val Asn Asn Val Thr Ser Glu Arg Leu Tyr Arg Glu Leu
    5010                5015                5020                
Tyr His Lys Leu Lys Asp Lys Ile His Thr Thr Pro Asp Pro Pro Glu
5025                5030                5035                5040
Ile Arg Gln Val Lys Lys Thr Gln Glu Ala Val Ser Glu Leu Ile Tyr
                5045                5050                5055    
Lys Ser Asp Phe Phe Lys Met Gln Gly His Met Ile Ser Leu Pro Tyr
            5060                5065                5070        
Thr Pro Gln Val Ile His Cys Arg Tyr Val Gly Asp Ile Thr Ser Asp
        5075                5080                5085            
Ile Lys Tyr Lys Glu Asp Leu Gln Val Leu Lys Gly Phe Gly Cys Phe
    5090                5095                5100                
Leu Tyr Asp Thr Pro Asp Met Val Arg Ser Arg His Leu Arg Lys Leu
5105                5110                5115                5120
Trp Ser Asn Tyr Leu Tyr Thr Asp Lys Ala Arg Glu Met Arg Asp Lys
                5125                5130                5135    
Tyr Lys Val Val Leu Asp Thr Pro Glu Tyr Arg Lys Val Gln Glu Leu
            5140                5145                5150        
Lys Thr His Leu Ser Glu Leu Val Tyr Arg Ala Ala Gly Lys Lys Gln
        5155                5160                5165            
Lys Ser Ile Phe Thr Ser Val Pro Asp Thr Pro Asp Leu Leu Arg Ala
    5170                5175                5180                
Lys Arg Gly Gln Lys Leu Gln Ser Gln Tyr Leu Tyr Val Glu Leu Ala
5185                5190                5195                5200
Thr Lys Glu Arg Pro His His His Ala Gly Asn Gln Thr Thr Ala Leu
                5205                5210                5215    
Lys His Ala Lys Asp Val Lys Asp Met Val Ser Glu Lys Lys Tyr Lys
            5220                5225                5230        
Ile Gln Tyr Glu Lys Met Lys Asp Lys Tyr Thr Pro Val Pro Asp Thr
        5235                5240                5245            
Pro Ile Leu Ile Arg Ala Lys Arg Ala Tyr Trp Asn Ala Ser Asp Leu
    5250                5255                5260                
Arg Tyr Lys Glu Thr Phe Gln Lys Thr Lys Gly Lys Tyr His Thr Val
5265                5270                5275                5280
Lys Asp Ala Leu Asp Ile Val Tyr His Arg Lys Val Thr Asp Asp Ile
                5285                5290                5295    
Ser Lys Ile Lys Tyr Lys Glu Asn Tyr Met Ser Gln Leu Gly Ile Trp
            5300                5305                5310        
Arg Ser Ile Pro Asp Arg Pro Glu His Phe His His Arg Ala Val Thr
        5315                5320                5325            
Asp Thr Val Ser Asp Val Lys Tyr Lys Glu Asp Leu Thr Trp Leu Lys
    5330                5335                5340                
Gly Ile Gly Cys Tyr Ala Tyr Asp Thr Pro Asp Phe Thr Leu Ala Glu
5345                5350                5355                5360
Lys Asn Lys Thr Leu Tyr Ser Lys Tyr Lys Tyr Lys Glu Val Phe Glu
                5365                5370                5375    
Arg Thr Lys Ser Asp Phe Lys Tyr Val Ala Asp Ser Pro Ile Asn Arg
            5380                5385                5390        
His Phe Lys Tyr Ala Thr Gln Leu Met Asn Glu Lys Lys Tyr Arg Ala
        5395                5400                5405            
Asp Tyr Glu Gln Arg Lys Asp Lys Tyr His Leu Val Val Asp Glu Pro
    5410                5415                5420                
Arg His Leu Leu Ala Lys Thr Arg Ser Asp Gln Ile Ser Gln Ile Lys
5425                5430                5435                5440
Tyr Arg Lys Asn Tyr Glu Lys Ser Lys Asp Lys Phe Thr Ser Ile Val
                5445                5450                5455    
Asp Thr Pro Glu His Leu Arg Thr Thr Lys Val Asn Lys Gln Ile Ser
            5460                5465                5470        
Asp Ile Leu Tyr Lys Leu Glu Tyr Asn Lys Ala Lys Pro Arg Gly Tyr
        5475                5480                5485            
Thr Thr Ile His Asp Thr Pro Met Leu Leu His Val Arg Lys Val Lys
    5490                5495                5500                
Asp Glu Val Ser Asp Leu Lys Tyr Lys Glu Val Tyr Gln Arg Asn Lys
5505                5510                5515                5520
Ser Asn Cys Thr Ile Glu Pro Asp Ala Val His Ile Lys Ala Ala Lys
                5525                5530                5535    
Asp Ala Tyr Lys Val Asn Thr Asn Leu Asp Tyr Lys Lys Gln Tyr Glu
            5540                5545                5550        
Ala Asn Lys Ala His Trp Lys Trp Thr Pro Asp Arg Pro Asp Phe Leu
        5555                5560                5565            
Gln Ala Ala Lys Ser Ser Leu Gln Gln Ser Asp Phe Glu Tyr Lys Leu
    5570                5575                5580                
Asp Arg Glu Phe Leu Lys Gly Cys Lys Leu Ser Val Thr Asp Asp Lys
5585                5590                5595                5600
Asn Thr Val Leu Ala Leu Arg Asn Thr Leu Ile Glu Ser Asp Leu Lys
                5605                5610                5615    
Tyr Lys Glu Lys His Val Lys Glu Arg Gly Thr Cys His Ala Val Pro
            5620                5625                5630        
Asp Thr Pro Gln Ile Leu Leu Ala Lys Thr Val Ser Asn Leu Val Ser
        5635                5640                5645            
Glu Asn Lys Tyr Lys Asp His Val Lys Lys His Leu Ala Gln Gly Ser
    5650                5655                5660                
Tyr Thr Thr Leu Pro Glu Thr Arg Asp Thr Val His Val Lys Glu Val
5665                5670                5675                5680
Thr Lys His Val Ser Asp Thr Asn Tyr Lys Lys Lys Phe Val Lys Glu
                5685                5690                5695    
Lys Gly Lys Ser Asn Tyr Ser Ile Met Leu Glu Pro Pro Glu Val Lys
            5700                5705                5710        
His Ala Met Glu Val Ala Lys Lys Gln Ser Asp Val Ala Tyr Arg Lys
        5715                5720                5725            
Asp Ala Lys Glu Asn Leu His Tyr Thr Thr Val Ala Asp Arg Pro Asp
    5730                5735                5740                
Ile Lys Lys Ala Thr Gln Ala Ala Lys Gln Ala Ser Glu Val Glu Tyr
5745                5750                5755                5760
Arg Ala Lys His Arg Lys Glu Gly Ser His Gly Leu Ser Met Leu Gly
                5765                5770                5775    
Arg Pro Asp Ile Glu Met Ala Lys Lys Ala Ala Lys Leu Ser Ser Gln
            5780                5785                5790        
Val Lys Tyr Arg Glu Asn Phe Asp Lys Glu Lys Gly Lys Thr Pro Lys
        5795                5800                5805            
Tyr Asn Pro Lys Asp Ser Gln Leu Tyr Lys Val Met Lys Asp Ala Asn
    5810                5815                5820                
Asn Leu Ala Ser Glu Val Lys Tyr Lys Ala Asp Leu Lys Lys Leu His
5825                5830                5835                5840
Lys Pro Val Thr Asp Met Lys Glu Ser Leu Ile Met Asn His Val Leu
                5845                5850                5855    
Asn Thr Ser Gln Leu Ala Ser Ser Tyr Gln Tyr Lys Lys Lys Tyr Glu
            5860                5865                5870        
Lys Ser Lys Gly His Tyr His Thr Ile Pro Asp Asn Leu Glu Gln Leu
        5875                5880                5885            
His Leu Lys Glu Ala Thr Glu Leu Gln Ser Ile Val Lys Tyr Lys Glu
    5890                5895                5900                
Lys Tyr Glu Lys Glu Arg Gly Lys Pro Met Leu Asp Phe Glu Thr Pro
5905                5910                5915                5920
Thr Tyr Ile Thr Ala Lys Glu Ser Gln Gln Met Gln Ser Gly Lys Glu
                5925                5930                5935    
Tyr Arg Lys Asp Tyr Glu Glu Ser Ile Lys Gly Arg Asn Leu Thr Gly
            5940                5945                5950        
Leu Glu Val Thr Pro Ala Leu Leu His Val Lys Tyr Ala Thr Lys Ile
        5955                5960                5965            
Ala Ser Glu Lys Glu Tyr Arg Lys Asp Leu Glu Glu Ser Ile Arg Gly
    5970                5975                5980                
Lys Gly Leu Thr Glu Met Glu Asp Thr Pro Asp Met Leu Arg Ala Lys
5985                5990                5995                6000
Asn Ala Thr Gln Ile Leu Asn Glu Lys Glu Tyr Lys Arg Asp Leu Glu
                6005                6010                6015    
Leu Glu Val Lys Gly Arg Gly Leu Asn Ala Met Ala Asn Glu Thr Pro
            6020                6025                6030        
Asp Phe Met Arg Ala Arg Asn Ala Thr Asp Ile Ala Ser Gln Ile Lys
        6035                6040                6045            
Tyr Lys Gln Ser Ala Glu Met Glu Lys Ala Asn Phe Thr Ser Val Val
    6050                6055                6060                
Asp Thr Pro Glu Ile Ile His Ala Gln Gln Val Lys Asn Leu Ser Ser
6065                6070                6075                6080
Gln Lys Lys Tyr Lys Glu Asp Ala Glu Lys Ser Met Ser Tyr Tyr Glu
                6085                6090                6095    
Thr Val Leu Asp Thr Pro Glu Ile Gln Arg Val Arg Glu Asn Gln Lys
            6100                6105                6110        
Asn Phe Ser Leu Leu Gln Tyr Gln Cys Asp Leu Lys Asn Ser Lys Gly
        6115                6120                6125            
Lys Ile Thr Val Val Gln Asp Thr Pro Glu Ile Leu Arg Val Lys Glu
    6130                6135                6140                
Asn Gln Lys Asn Phe Ser Ser Val Leu Tyr Lys Glu Asp Val Ser Pro
6145                6150                6155                6160
Gly Thr Ala Ile Gly Lys Thr Pro Glu Met Met Arg Val Lys Gln Thr
                6165                6170                6175    
Gln Asp His Ile Ser Ser Val Lys Tyr Lys Glu Ala Ile Gly Gln Gly
            6180                6185                6190        
Thr Pro Ile Pro Asp Leu Pro Glu Val Lys Arg Val Lys Glu Thr Gln
        6195                6200                6205            
Lys His Ile Ser Ser Val Met Tyr Lys Glu Asn Leu Gly Thr Gly Ile
    6210                6215                6220                
Pro Thr Thr Val Thr Pro Glu Ile Glu Arg Val Lys Arg Asn Gln Glu
6225                6230                6235                6240
Asn Phe Ser Ser Val Leu Tyr Lys Glu Asn Leu Gly Lys Gly Ile Pro
                6245                6250                6255    
Thr Pro Ile Thr Pro Glu Met Glu Arg Val Lys Arg Asn Gln Glu Asn
            6260                6265                6270        
Phe Ser Ser Val Leu Tyr Lys Glu Asn Met Gly Lys Gly Thr Pro Leu
        6275                6280                6285            
Pro Val Thr Pro Glu Met Glu Arg Val Lys His Asn Gln Glu Asn Ile
    6290                6295                6300                
Ser Ser Val Leu Tyr Lys Glu Asn Val Gly Lys Ala Thr Ala Thr Pro
6305                6310                6315                6320
Val Thr Pro Glu Met Gln Arg Val Lys Arg Asn Gln Glu Asn Ile Ser
                6325                6330                6335    
Ser Val Leu Tyr Lys Glu Asn Leu Gly Lys Ala Thr Pro Thr Pro Phe
            6340                6345                6350        
Thr Pro Glu Met Glu Arg Val Lys Arg Asn Gln Glu Asn Phe Ser Ser
        6355                6360                6365            
Val Leu Tyr Lys Glu Asn Met Arg Lys Ala Thr Pro Thr Pro Val Thr
    6370                6375                6380                
Pro Glu Met Glu Arg Ala Lys Arg Asn Gln Glu Asn Ile Ser Ser Val
6385                6390                6395                6400
Leu Tyr Ser Asp Ser Phe Arg Lys Gln Ile Gln Gly Lys Ala Ala Tyr
                6405                6410                6415    
Val Leu Asp Thr Pro Glu Met Arg Arg Val Arg Glu Thr Gln Arg His
            6420                6425                6430        
Ile Ser Thr Val Lys Tyr His Glu Asp Phe Glu Lys His Lys Gly Cys
        6435                6440                6445            
Phe Thr Pro Val Val Thr Asp Pro Ile Thr Glu Arg Val Lys Lys Asn
    6450                6455                6460                
Met Gln Asp Phe Ser Asp Ile Asn Tyr Arg Gly Ile Gln Arg Lys Val
6465                6470                6475                6480
Val Glu Met Glu Gln Lys Arg Asn Asp Gln Asp Gln Glu Thr Ile Thr
                6485                6490                6495    
Gly Leu Arg Val Trp Arg Thr Asn Pro Gly Ser Val Phe Asp Tyr Asp
            6500                6505                6510        
Pro Ala Glu Asp Asn Ile Gln Ser Arg Ser Leu His Met Ile Asn Val
        6515                6520                6525            
Gln Ala Gln Arg Arg Ser Arg Glu Gln Ser Arg Ser Ala Ser Ala Leu
    6530                6535                6540                
Ser Val Ser Gly Gly Glu Glu Lys Ser Glu His Ser Glu Ala Pro Asp
6545                6550                6555                6560
His His Leu Ser Thr Tyr Ser Asp Gly Gly Val Phe Ala Val Ser Thr
                6565                6570                6575    
Ala Tyr Lys His Ala Lys Thr Thr Glu Leu Pro Gln Gln Arg Ser Ser
            6580                6585                6590        
Ser Val Ala Thr Gln Gln Thr Thr Val Ser Ser Ile Pro Ser His Pro
        6595                6600                6605            
Ser Thr Ala Gly Lys Ile Phe Arg Ala Met Tyr Asp Tyr Met Ala Ala
    6610                6615                6620                
Asp Ala Asp Glu Val Ser Phe Lys Asp Gly Asp Ala Ile Ile Asn Val
6625                6630                6635                6640
Gln Ala Ile Asp Glu Gly Trp Met Tyr Gly Thr Val Gln Arg Thr Gly
                6645                6650                6655    
Arg Thr Gly Met Leu Pro Ala Asn Tyr Val Glu Ala Ile
            6660                6665                


<210> 6990
<211> 977
<212> PRT
<213> Homo sapiens

<400> 6990
Val Ala Tyr Arg Lys Asp Ala Lys Glu Asn Leu His Tyr Thr Thr Val
 1               5                  10                  15      
Ala Asp Arg Pro Asp Ile Lys Lys Ala Thr Gln Ala Ala Lys Gln Ala
            20                  25                  30          
Ser Glu Val Glu Tyr Arg Ala Lys His Arg Lys Glu Gly Ser His Gly
        35                  40                  45              
Leu Ser Met Leu Gly Arg Pro Asp Ile Glu Met Ala Lys Lys Ala Ala
    50                  55                  60                  
Lys Leu Ser Ser Gln Val Lys Tyr Arg Glu Asn Phe Asp Lys Glu Lys
65                  70                  75                  80  
Gly Lys Thr Pro Lys Tyr Asn Pro Lys Asp Ser Gln Leu Tyr Lys Val
                85                  90                  95      
Met Lys Asp Ala Asn Asn Leu Ala Ser Glu Val Lys Tyr Lys Ala Asp
            100                 105                 110         
Leu Lys Lys Leu His Lys Pro Val Thr Asp Met Lys Glu Ser Leu Ile
        115                 120                 125             
Met Asn His Val Leu Asn Thr Ser Gln Leu Ala Ser Ser Tyr Gln Tyr
    130                 135                 140                 
Lys Lys Lys Tyr Glu Lys Ser Lys Gly His Tyr His Thr Ile Pro Asp
145                 150                 155                 160 
Asn Leu Glu Gln Leu His Leu Lys Glu Ala Thr Glu Leu Gln Ser Ile
                165                 170                 175     
Val Lys Tyr Lys Glu Lys Tyr Glu Lys Glu Arg Gly Lys Pro Met Leu
            180                 185                 190         
Asp Phe Glu Thr Pro Thr Tyr Ile Thr Ala Lys Glu Ser Gln Gln Met
        195                 200                 205             
Gln Ser Gly Lys Glu Tyr Arg Lys Asp Tyr Glu Glu Ser Ile Lys Gly
    210                 215                 220                 
Arg Asn Leu Thr Gly Leu Glu Val Thr Pro Ala Leu Leu His Val Lys
225                 230                 235                 240 
Tyr Ala Thr Lys Ile Ala Ser Glu Lys Glu Tyr Arg Lys Asp Leu Glu
                245                 250                 255     
Glu Ser Ile Arg Gly Lys Gly Leu Thr Glu Met Glu Asp Thr Pro Asp
            260                 265                 270         
Met Leu Arg Ala Lys Asn Ala Thr Gln Ile Leu Asn Glu Lys Glu Tyr
        275                 280                 285             
Lys Arg Asp Leu Glu Leu Glu Val Lys Gly Arg Gly Leu Asn Ala Met
    290                 295                 300                 
Ala Asn Glu Thr Pro Asp Phe Met Arg Ala Arg Asn Ala Thr Asp Ile
305                 310                 315                 320 
Ala Ser Gln Ile Lys Tyr Lys Gln Ser Ala Glu Met Glu Lys Ala Asn
                325                 330                 335     
Phe Thr Ser Val Val Asp Thr Pro Glu Ile Ile His Ala Gln Gln Val
            340                 345                 350         
Lys Asn Leu Ser Ser Gln Lys Lys Tyr Lys Glu Asp Ala Glu Lys Ser
        355                 360                 365             
Met Ser Tyr Tyr Glu Thr Val Leu Asp Thr Pro Glu Ile Gln Arg Val
    370                 375                 380                 
Arg Glu Asn Gln Lys Asn Phe Ser Leu Leu Gln Tyr Gln Cys Asp Leu
385                 390                 395                 400 
Lys Asn Ser Lys Gly Lys Ile Thr Val Val Gln Asp Thr Pro Glu Ile
                405                 410                 415     
Leu Arg Val Lys Glu Asn Gln Lys Asn Phe Ser Ser Val Leu Tyr Lys
            420                 425                 430         
Glu Asp Val Ser Pro Gly Thr Ala Ile Gly Lys Thr Pro Glu Met Met
        435                 440                 445             
Arg Val Lys Gln Thr Gln Asp His Ile Ser Ser Val Lys Tyr Lys Glu
    450                 455                 460                 
Ala Ile Gly Gln Gly Thr Pro Ile Pro Asp Leu Pro Glu Val Lys Arg
465                 470                 475                 480 
Val Lys Glu Thr Gln Lys His Ile Ser Ser Val Met Tyr Lys Glu Asn
                485                 490                 495     
Leu Gly Thr Gly Ile Pro Thr Thr Val Thr Pro Glu Ile Glu Arg Val
            500                 505                 510         
Lys Arg Asn Gln Glu Asn Phe Ser Ser Val Leu Tyr Lys Glu Asn Leu
        515                 520                 525             
Gly Lys Gly Ile Pro Thr Pro Ile Thr Pro Glu Met Glu Arg Val Lys
    530                 535                 540                 
Arg Asn Gln Glu Asn Phe Ser Ser Val Leu Tyr Lys Glu Asn Met Gly
545                 550                 555                 560 
Lys Gly Thr Pro Leu Pro Val Thr Pro Glu Met Glu Arg Val Lys His
                565                 570                 575     
Asn Gln Glu Asn Ile Ser Ser Val Leu Tyr Lys Glu Asn Met Gly Lys
            580                 585                 590         
Gly Thr Pro Leu Pro Val Thr Pro Glu Met Glu Arg Val Lys His Asn
        595                 600                 605             
Gln Glu Asn Ile Ser Ser Val Leu Tyr Lys Glu Asn Val Gly Lys Ala
    610                 615                 620                 
Thr Ala Thr Pro Val Thr Pro Glu Met Gln Arg Val Lys Arg Asn Gln
625                 630                 635                 640 
Glu Asn Ile Ser Ser Val Leu Tyr Lys Glu Asn Leu Gly Lys Ala Thr
                645                 650                 655     
Pro Thr Pro Phe Thr Pro Glu Met Glu Arg Val Lys Arg Asn Gln Glu
            660                 665                 670         
Asn Phe Ser Ser Val Leu Tyr Lys Glu Asn Met Arg Lys Ala Thr Pro
        675                 680                 685             
Thr Pro Val Thr Pro Glu Met Glu Arg Ala Lys Arg Asn Gln Glu Asn
    690                 695                 700                 
Ile Ser Ser Val Leu Tyr Ser Asp Ser Phe Arg Lys Gln Ile Gln Gly
705                 710                 715                 720 
Lys Ala Ala Tyr Val Leu Asp Thr Pro Glu Met Arg Arg Val Arg Glu
                725                 730                 735     
Thr Gln Arg His Ile Ser Thr Val Lys Tyr His Glu Asp Phe Glu Lys
            740                 745                 750         
His Lys Gly Cys Phe Thr Pro Val Val Thr Asp Pro Ile Thr Glu Arg
        755                 760                 765             
Val Lys Lys Asn Met Gln Asp Phe Ser Asp Ile Asn Tyr Arg Gly Ile
    770                 775                 780                 
Gln Arg Lys Val Val Glu Met Glu Gln Lys Arg Asn Asp Gln Asp Gln
785                 790                 795                 800 
Glu Thr Ile Thr Gly Leu Arg Val Trp Arg Thr Asn Pro Gly Ser Val
                805                 810                 815     
Phe Asp Tyr Asp Pro Ala Glu Asp Asn Ile Gln Ser Arg Ser Leu His
            820                 825                 830         
Met Ile Asn Val Gln Ala Gln Arg Arg Ser Arg Glu Gln Ser Arg Ser
        835                 840                 845             
Ala Ser Ala Leu Ser Ile Ser Gly Gly Glu Glu Lys Ser Glu His Ser
    850                 855                 860                 
Glu Ala Pro Asp His His Leu Ser Thr Tyr Ser Asp Gly Gly Val Phe
865                 870                 875                 880 
Ala Val Ser Thr Ala Tyr Lys His Ala Lys Thr Thr Glu Leu Pro Gln
                885                 890                 895     
Gln Arg Ser Ser Ser Val Ala Thr Gln Gln Thr Thr Val Ser Ser Ile
            900                 905                 910         
Pro Ser His Pro Ser Thr Ala Gly Lys Ile Phe Arg Ala Met Tyr Asp
        915                 920                 925             
Tyr Met Ala Ala Asp Ala Asp Glu Val Ser Phe Lys Asp Gly Asp Ala
    930                 935                 940                 
Ile Ile Asn Val Gln Ala Ile Asp Glu Gly Trp Met Tyr Gly Thr Val
945                 950                 955                 960 
Gln Arg Thr Gly Arg Thr Gly Met Leu Pro Ala Asn Tyr Val Glu Ala
                965                 970                 975     
Ile
    


<210> 6991
<211> 316
<212> PRT
<213> Homo sapiens

<400> 6991
Gly Thr Gly Ser Ala Ala Gly Ala Ala Ala Arg Thr Arg Ser Ser Gly
 1               5                  10                  15      
Pro Pro Pro Pro Ala Val Pro Ala Ser Arg Val Tyr Pro Arg Ala Leu
            20                  25                  30          
Lys Glu Val Arg Gln Pro Ser Pro Ala Pro Ala Asp Arg Ala Met Ala
        35                  40                  45              
Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala Arg Arg
65                  70                  75                  80  
Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly Leu Ser
                85                  90                  95      
Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu Gly Val
            100                 105                 110         
Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr Glu Glu
        115                 120                 125             
Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly Asp Phe
    130                 135                 140                 
Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg Ser Thr
145                 150                 155                 160 
Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr Glu Pro
                165                 170                 175     
Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu Asp Glu
            180                 185                 190         
Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His Ala Glu
        195                 200                 205             
His Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp
    210                 215                 220                 
Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp
225                 230                 235                 240 
Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp
                245                 250                 255     
Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu
            260                 265                 270         
Glu Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp
        275                 280                 285             
Asn Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe
    290                 295                 300                 
Pro Val Glu Glu Gln Gln Glu Val Pro Pro Asp Thr
305                 310                 315     


<210> 6992
<211> 758
<212> PRT
<213> Homo sapiens

<400> 6992
Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser
 1               5                  10                  15      
Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala
            20                  25                  30          
Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly
        35                  40                  45              
Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu
    50                  55                  60                  
Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr
65                  70                  75                  80  
Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly
                85                  90                  95      
Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg
            100                 105                 110         
Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr
        115                 120                 125             
Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu
    130                 135                 140                 
Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His
145                 150                 155                 160 
Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr
                165                 170                 175     
Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val
            180                 185                 190         
Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr
        195                 200                 205             
Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln
    210                 215                 220                 
Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu
225                 230                 235                 240 
Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr
                245                 250                 255     
Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu
            260                 265                 270         
Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val
        275                 280                 285             
Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu
    290                 295                 300                 
Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro
305                 310                 315                 320 
Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys
                325                 330                 335     
Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg
            340                 345                 350         
Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val
        355                 360                 365             
Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys
    370                 375                 380                 
Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly
385                 390                 395                 400 
Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala
                405                 410                 415     
Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe
            420                 425                 430         
Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln
        435                 440                 445             
Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr
    450                 455                 460                 
Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val
465                 470                 475                 480 
Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe
                485                 490                 495     
Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys
            500                 505                 510         
Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr
        515                 520                 525             
Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr
    530                 535                 540                 
Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp
545                 550                 555                 560 
Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp
                565                 570                 575     
Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg
            580                 585                 590         
Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala
        595                 600                 605             
Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp
    610                 615                 620                 
Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala
625                 630                 635                 640 
Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu
                645                 650                 655     
Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro
            660                 665                 670         
Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg
        675                 680                 685             
Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys
    690                 695                 700                 
Ala Asn Glu Thr Arg Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp
705                 710                 715                 720 
Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu
                725                 730                 735     
Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg
            740                 745                 750         
Arg Ser Leu Pro Ala Ile
        755             


<210> 6993
<211> 313
<212> PRT
<213> Homo sapiens

<400> 6993
Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser
 1               5                  10                  15      
Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala
            20                  25                  30          
Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly
        35                  40                  45              
Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu
    50                  55                  60                  
Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr
65                  70                  75                  80  
Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly
                85                  90                  95      
Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg
            100                 105                 110         
Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr
        115                 120                 125             
Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu
    130                 135                 140                 
Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His
145                 150                 155                 160 
Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr
                165                 170                 175     
Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val
            180                 185                 190         
Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr
        195                 200                 205             
Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln
    210                 215                 220                 
Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu
225                 230                 235                 240 
Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr
                245                 250                 255     
Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu
            260                 265                 270         
Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val
        275                 280                 285             
Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu
    290                 295                 300                 
Glu Gln Gln Glu Val Pro Pro Asp Thr
305                 310             


<210> 6994
<211> 750
<212> PRT
<213> Homo sapiens

<400> 6994
Met Glu Asp Tyr Pro Asp Pro Gln Ser Ala Asn His Met Asn Ser Ser
 1               5                  10                  15      
Leu Leu Ser Leu Tyr Arg Lys Gly Asn Pro Asp Ser Val Ser Asn Thr
            20                  25                  30          
Pro Glu Met Glu Gln Arg Glu Thr Thr Ser Ser Thr Pro Arg Ile Ser
        35                  40                  45              
Ser Lys Thr Gly Ser Ile Pro Leu Lys Thr Pro Ala Lys Asp Ser Glu
    50                  55                  60                  
Gly Gly Trp Phe Ile Asp Lys Thr Pro Ser Val Lys Lys Asp Ser Phe
65                  70                  75                  80  
Phe Leu Asp Leu Ser Cys Glu Lys Ser Asn Pro Lys Lys Pro Ile Thr
                85                  90                  95      
Glu Ile Gln Asp Ser Lys Asp Ser Ser Leu Leu Glu Ser Asp Met Lys
            100                 105                 110         
Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys Arg Lys Lys Glu Asp
        115                 120                 125             
Leu Gln Glu Val Asp Gly Glu Ile Glu Ala Val Leu Gln Lys Lys Ala
    130                 135                 140                 
Lys Ala Arg Gly Leu Glu Phe Gln Ile Ser Asn Val Lys Phe Glu Asp
145                 150                 155                 160 
Val Gly Gly Asn Asp Met Thr Leu Lys Glu Val Cys Lys Met Leu Ile
                165                 170                 175     
His Met Arg His Pro Glu Val Tyr His His Leu Gly Val Val Pro Pro
            180                 185                 190         
Arg Gly Val Leu Leu His Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu
        195                 200                 205             
Ala His Ala Ile Ala Gly Glu Leu Asp Leu Pro Ile Leu Lys Val Ala
    210                 215                 220                 
Ala Pro Glu Ile Val Ser Gly Val Ser Gly Glu Ser Glu Gln Lys Leu
225                 230                 235                 240 
Arg Glu Leu Phe Glu Gln Ala Val Ser Asn Ala Pro Cys Ile Ile Phe
                245                 250                 255     
Ile Asp Glu Ile Asp Ala Ile Thr Pro Lys Arg Glu Val Ala Ser Lys
            260                 265                 270         
Asp Met Glu Arg Arg Ile Val Ala Gln Leu Leu Thr Cys Met Asp Asp
        275                 280                 285             
Leu Asn Asn Val Ala Ala Thr Ala Arg Val Leu Val Ile Gly Ala Thr
    290                 295                 300                 
Asn Arg Pro Asp Ser Leu Asp Pro Ala Leu Arg Arg Ala Gly Arg Phe
305                 310                 315                 320 
Asp Arg Glu Ile Cys Leu Gly Ile Pro Asp Glu Ala Ser Arg Glu Arg
                325                 330                 335     
Ile Leu Gln Thr Leu Cys Arg Lys Leu Arg Leu Pro Gln Ala Phe Asp
            340                 345                 350         
Phe Cys His Leu Ala His Leu Thr Pro Gly Phe Val Gly Ala Asp Leu
        355                 360                 365             
Met Ala Leu Cys Arg Glu Ala Ala Met Cys Ala Val Asn Arg Val Leu
    370                 375                 380                 
Met Lys Leu Gln Glu Gln Gln Lys Lys Asn Pro Glu Met Glu Asp Leu
385                 390                 395                 400 
Pro Ser Lys Gly Val Gln Glu Glu Arg Leu Gly Thr Glu Pro Thr Ser
                405                 410                 415     
Glu Thr Gln Asp Glu Leu Gln Arg Leu Leu Gly Leu Leu Arg Asp Gln
            420                 425                 430         
Asp Pro Leu Ser Glu Glu Gln Met Gln Gly Leu Cys Ile Glu Leu Asn
        435                 440                 445             
Asp Phe Ile Val Ala Leu Ser Ser Val Gln Pro Ser Ala Lys Arg Glu
    450                 455                 460                 
Gly Phe Val Thr Val Pro Asn Val Thr Trp Ala Asp Ile Gly Ala Leu
465                 470                 475                 480 
Glu Asp Ile Arg Glu Glu Leu Thr Met Ala Ile Leu Ala Pro Val Arg
                485                 490                 495     
Asn Pro Asp Gln Phe Lys Ala Leu Gly Leu Val Thr Pro Ala Gly Val
            500                 505                 510         
Leu Leu Ala Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Lys Ala
        515                 520                 525             
Val Ala Asn Glu Ser Gly Leu Asn Phe Ile Ser Val Lys Gly Pro Glu
    530                 535                 540                 
Leu Leu Asn Met Tyr Val Gly Glu Ser Glu Arg Ala Val Arg Gln Val
545                 550                 555                 560 
Phe Gln Arg Ala Lys Asn Ser Ala Pro Cys Val Ile Phe Phe Asp Glu
                565                 570                 575     
Val Asp Ala Leu Cys Pro Arg Arg Ser Asp Arg Glu Thr Gly Ala Ser
            580                 585                 590         
Val Arg Val Val Asn Gln Leu Leu Thr Glu Met Asp Gly Leu Glu Ala
        595                 600                 605             
Arg Gln Gln Val Phe Ile Met Ala Ala Thr Asn Arg Pro Asp Ile Ile
    610                 615                 620                 
Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp Lys Thr Leu Phe Val
625                 630                 635                 640 
Gly Leu Pro Pro Pro Ala Asp Arg Leu Ala Ile Leu Lys Thr Ile Thr
                645                 650                 655     
Lys Asn Gly Thr Lys Pro Pro Leu Asp Ala Asp Val Asn Leu Glu Ala
            660                 665                 670         
Ile Ala Gly Asp Leu Arg Cys Asp Cys Tyr Thr Gly Ala Asp Leu Ser
        675                 680                 685             
Ala Leu Val Arg Glu Ala Ser Ile Cys Ala Leu Arg Gln Glu Met Ala
    690                 695                 700                 
Arg Gln Lys Ser Gly Asn Glu Lys Gly Glu Leu Lys Val Ser His Lys
705                 710                 715                 720 
His Phe Glu Glu Ala Phe Lys Lys Val Arg Ser Ser Ile Ser Lys Lys
                725                 730                 735     
Asp Gln Ile Met Tyr Glu Arg Leu Gln Glu Ser Leu Ser Arg
            740                 745                 750 


<210> 6995
<211> 856
<212> PRT
<213> Homo sapiens

<400> 6995
Met Lys Pro Arg Pro Ala Gly Phe Val Asp Asn Lys Leu Lys Gln Arg
 1               5                  10                  15      
Val Ile Gln Tyr Leu Thr Ser Asn Lys Cys Gly Lys Tyr Val Asp Ile
            20                  25                  30          
Gly Val Leu Ala Ser Asp Leu Gln Arg Val Tyr Ser Ile Asp Tyr Gly
        35                  40                  45              
Arg Arg Lys Arg Asn Ala Phe Arg Ile Gln Val Glu Lys Val Phe Ser
    50                  55                  60                  
Ile Ile Ser Ser Glu Lys Glu Leu Lys Asn Leu Thr Glu Leu Glu Asp
65                  70                  75                  80  
Glu His Leu Ala Lys Arg Ala Arg Gln Gly Glu Glu Asp Asn Glu Tyr
                85                  90                  95      
Thr Glu Ser Tyr Ser Asp Asp Asp Ser Ser Met Glu Asp Tyr Pro Asp
            100                 105                 110         
Pro Gln Ser Ala Asn His Met Asn Ser Ser Leu Leu Ser Leu Tyr Arg
        115                 120                 125             
Lys Gly Asn Pro Asp Ser Val Ser Asn Thr Pro Glu Met Glu Gln Arg
    130                 135                 140                 
Glu Thr Thr Ser Ser Thr Pro Arg Ile Ser Ser Lys Thr Gly Ser Ile
145                 150                 155                 160 
Pro Leu Lys Thr Pro Ala Lys Asp Ser Glu Gly Gly Trp Phe Ile Asp
                165                 170                 175     
Lys Thr Pro Ser Val Lys Lys Asp Ser Phe Phe Leu Asp Leu Ser Cys
            180                 185                 190         
Glu Lys Ser Asn Pro Lys Lys Pro Ile Thr Glu Ile Gln Asp Ser Lys
        195                 200                 205             
Asp Ser Ser Leu Leu Glu Ser Asp Met Lys Arg Lys Gly Lys Leu Lys
    210                 215                 220                 
Asn Lys Gly Ser Lys Arg Lys Lys Glu Asp Leu Gln Glu Val Asp Gly
225                 230                 235                 240 
Glu Ile Glu Ala Val Leu Gln Lys Lys Ala Lys Ala Arg Gly Leu Glu
                245                 250                 255     
Phe Gln Ile Ser Asn Val Lys Phe Glu Asp Val Gly Gly Asn Asp Met
            260                 265                 270         
Thr Leu Lys Glu Val Cys Lys Met Leu Ile His Met Arg His Pro Glu
        275                 280                 285             
Val Tyr His His Leu Gly Val Val Pro Pro Arg Gly Val Leu Leu His
    290                 295                 300                 
Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala His Ala Ile Ala Gly
305                 310                 315                 320 
Glu Leu Asp Leu Pro Ile Leu Lys Val Ala Ala Pro Glu Ile Val Ser
                325                 330                 335     
Gly Val Ser Gly Glu Ser Glu Gln Lys Leu Arg Glu Leu Phe Glu Gln
            340                 345                 350         
Ala Val Ser Asn Ala Pro Cys Ile Ile Phe Ile Asp Glu Ile Asp Ala
        355                 360                 365             
Ile Thr Pro Lys Arg Glu Val Ala Ser Lys Asp Met Glu Arg Arg Ile
    370                 375                 380                 
Val Ala Gln Leu Leu Thr Cys Met Asp Asp Leu Asn Asn Val Ala Ala
385                 390                 395                 400 
Thr Ala Arg Val Leu Val Ile Gly Ala Thr Asn Arg Pro Asp Ser Leu
                405                 410                 415     
Asp Pro Ala Leu Arg Arg Ala Gly Arg Phe Asp Arg Glu Ile Cys Leu
            420                 425                 430         
Gly Ile Pro Asp Glu Ala Ser Arg Glu Arg Ile Leu Gln Thr Leu Cys
        435                 440                 445             
Arg Lys Leu Arg Leu Pro Gln Ala Phe Asp Phe Cys His Leu Ala His
    450                 455                 460                 
Leu Thr Pro Gly Phe Val Gly Ala Asp Leu Met Ala Leu Cys Arg Glu
465                 470                 475                 480 
Ala Ala Met Cys Ala Val Asn Arg Val Leu Met Lys Leu Gln Glu Gln
                485                 490                 495     
Gln Lys Lys Asn Pro Glu Met Glu Asp Leu Pro Ser Lys Gly Val Gln
            500                 505                 510         
Glu Glu Arg Leu Gly Thr Glu Pro Thr Ser Glu Thr Gln Asp Glu Leu
        515                 520                 525             
Gln Arg Leu Leu Gly Leu Leu Arg Asp Gln Asp Pro Leu Ser Glu Glu
    530                 535                 540                 
Gln Met Gln Gly Leu Cys Ile Glu Leu Asn Asp Phe Ile Val Ala Leu
545                 550                 555                 560 
Ser Ser Val Gln Pro Ser Ala Lys Arg Glu Gly Phe Val Thr Val Pro
                565                 570                 575     
Asn Val Thr Trp Ala Asp Ile Gly Ala Leu Glu Asp Ile Arg Glu Glu
            580                 585                 590         
Leu Thr Met Ala Ile Leu Ala Pro Val Arg Asn Pro Asp Gln Phe Lys
        595                 600                 605             
Ala Leu Gly Leu Val Thr Pro Ala Gly Val Leu Leu Ala Gly Pro Pro
    610                 615                 620                 
Gly Cys Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Asn Glu Ser Gly
625                 630                 635                 640 
Leu Asn Phe Ile Ser Val Lys Gly Pro Glu Leu Leu Asn Met Tyr Val
                645                 650                 655     
Gly Glu Ser Glu Arg Ala Val Arg Gln Val Phe Gln Arg Ala Lys Asn
            660                 665                 670         
Ser Ala Pro Cys Val Ile Phe Phe Asp Glu Val Asp Ala Leu Cys Pro
        675                 680                 685             
Arg Arg Ser Asp Arg Glu Thr Gly Ala Ser Val Arg Val Val Asn Gln
    690                 695                 700                 
Leu Leu Thr Glu Met Asp Gly Leu Glu Ala Arg Gln Gln Val Phe Ile
705                 710                 715                 720 
Met Ala Ala Thr Asn Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg
                725                 730                 735     
Pro Gly Arg Leu Asp Lys Thr Leu Phe Val Gly Leu Pro Pro Pro Ala
            740                 745                 750         
Asp Arg Leu Ala Ile Leu Lys Thr Ile Thr Lys Asn Gly Thr Lys Pro
        755                 760                 765             
Pro Leu Asp Ala Asp Val Asn Leu Glu Ala Ile Ala Gly Asp Leu Arg
    770                 775                 780                 
Cys Asp Cys Tyr Thr Gly Ala Asp Leu Ser Ala Leu Val Arg Glu Ala
785                 790                 795                 800 
Ser Ile Cys Ala Leu Arg Gln Glu Met Ala Arg Gln Lys Ser Gly Asn
                805                 810                 815     
Glu Lys Gly Glu Leu Lys Val Ser His Lys His Phe Glu Glu Ala Phe
            820                 825                 830         
Lys Lys Val Arg Ser Ser Ile Ser Lys Lys Asp Gln Ile Met Tyr Glu
        835                 840                 845             
Arg Leu Gln Glu Ser Leu Ser Arg
    850                 855     


<210> 6996
<211> 790
<212> PRT
<213> Homo sapiens

<400> 6996
His Ala Cys Val Ile Arg Gly Gln Val Met Thr Ser Asp Gly Thr Pro
 1               5                  10                  15      
Leu Val Gly Val Asn Ile Ser Phe Val Asn Asn Pro Leu Phe Gly Tyr
            20                  25                  30          
Thr Ile Ser Arg Gln Asp Gly Ser Phe Asp Leu Val Thr Asn Gly Gly
        35                  40                  45              
Ile Ser Ile Ile Leu Arg Phe Glu Arg Ala Pro Phe Ile Thr Gln Glu
    50                  55                  60                  
His Thr Leu Trp Leu Pro Trp Asp Arg Phe Phe Val Met Glu Thr Ile
65                  70                  75                  80  
Ile Met Arg His Glu Glu Asn Glu Ile Pro Ser Cys Asp Leu Ser Asn
                85                  90                  95      
Phe Ala Arg Pro Asn Pro Val Val Ser Pro Ser Pro Leu Thr Ser Phe
            100                 105                 110         
Ala Ser Ser Cys Ala Glu Lys Gly Pro Ile Val Pro Glu Ile Gln Val
        115                 120                 125             
Pro Ser Phe Pro Asn Cys Ile Pro Pro Cys Phe Tyr Phe Ile Leu Gly
    130                 135                 140                 
Val Glu Glu Asp Leu Arg Asp Ser Gly Lys Arg Lys Asn Thr Ser Val
145                 150                 155                 160 
Gly Leu Gly Tyr Leu Ser Ser Arg Thr Pro Gly Tyr Lys Ser Val Leu
                165                 170                 175     
Arg Ile Ser Leu Thr His Pro Thr Ile Pro Phe Asn Leu Met Lys Val
            180                 185                 190         
His Leu Met Val Ala Val Glu Gly Arg Leu Phe Arg Lys Trp Phe Ala
        195                 200                 205             
Ala Ala Pro Asp Leu Ser Tyr Tyr Phe Ile Trp Asp Lys Thr Asp Val
    210                 215                 220                 
Tyr Asn Gln Lys Val Phe Gly Leu Ser Glu Ala Phe Val Ser Val Gly
225                 230                 235                 240 
Tyr Glu Tyr Glu Ser Cys Pro Asp Leu Ile Leu Trp Glu Lys Arg Thr
                245                 250                 255     
Thr Val Leu Gln Gly Tyr Glu Ile Asp Ala Ser Lys Leu Gly Gly Trp
            260                 265                 270         
Ser Leu Asp Lys His His Ala Leu Asn Ile Gln Ser Gly Ile Leu His
        275                 280                 285             
Lys Gly Asn Gly Glu Asn Gln Phe Val Ser Gln Gln Pro Pro Val Ile
    290                 295                 300                 
Gly Ser Ile Met Gly Asn Gly Arg Arg Arg Ser Ile Ser Cys Pro Ser
305                 310                 315                 320 
Cys Asn Gly Leu Ala Asp Gly Asn Lys Leu Leu Ala Pro Val Ala Leu
                325                 330                 335     
Thr Cys Gly Ser Asp Gly Ser Leu Tyr Val Gly Asp Phe Asn Tyr Ile
            340                 345                 350         
Arg Arg Ile Phe Pro Ser Gly Asn Val Thr Asn Ile Leu Glu Leu Arg
        355                 360                 365             
Tyr Val Ser Pro Ala His Lys Tyr Tyr Leu Ala Thr Asp Pro Met Ser
    370                 375                 380                 
Gly Ala Val Phe Leu Ser Asp Ser Asn Ser Arg Arg Val Phe Lys Ile
385                 390                 395                 400 
Lys Ser Thr Val Val Val Lys Asp Leu Val Lys Asn Ser Glu Val Val
                405                 410                 415     
Ala Gly Thr Gly Asp Gln Cys Leu Pro Phe Asp Asp Thr Arg Cys Gly
            420                 425                 430         
Asp Gly Gly Lys Ala Thr Glu Ala Thr Leu Thr Asn Pro Arg Gly Ile
        435                 440                 445             
Thr Val Asp Lys Phe Gly Leu Ile Tyr Phe Val Asp Gly Thr Met Ile
    450                 455                 460                 
Arg Arg Ile Asp Gln Asn Gly Ile Ile Ser Thr Leu Leu Gly Ser Asn
465                 470                 475                 480 
Asp Leu Thr Ser Ala Arg Pro Leu Ser Cys Asp Ser Val Met Asp Ile
                485                 490                 495     
Ser Gln Val His Leu Glu Trp Pro Thr Asp Leu Ala Ile Asn Pro Met
            500                 505                 510         
Asp Asn Ser Leu Tyr Val Leu Asp Asn Asn Val Val Leu Gln Ile Ser
        515                 520                 525             
Glu Asn His Gln Val Arg Ile Val Ala Gly Arg Pro Met His Cys Gln
    530                 535                 540                 
Val Pro Gly Ile Asp His Phe Leu Leu Ser Lys Val Ala Ile His Ala
545                 550                 555                 560 
Thr Leu Glu Ser Ala Thr Ala Leu Ala Val Ser His Asn Gly Val Leu
                565                 570                 575     
Tyr Ile Ala Glu Thr Asp Glu Lys Lys Ile Asn Arg Ile Arg Gln Val
            580                 585                 590         
Thr Thr Ser Gly Glu Ile Ser Leu Val Ala Gly Ala Pro Ser Gly Cys
        595                 600                 605             
Asp Cys Lys Asn Asp Ala Asn Cys Asp Cys Phe Ser Gly Asp Asp Gly
    610                 615                 620                 
Tyr Ala Lys Asp Ala Lys Leu Asn Thr Pro Ser Ser Leu Ala Val Cys
625                 630                 635                 640 
Ala Asp Gly Glu Leu Tyr Val Ala Asp Leu Gly Asn Ile Arg Ile Arg
                645                 650                 655     
Phe Ile Arg Lys Asn Lys Pro Phe Leu Asn Thr Gln Asn Met Tyr Glu
            660                 665                 670         
Leu Ser Ser Pro Ile Asp Gln Glu Leu Tyr Leu Phe Asp Thr Thr Gly
        675                 680                 685             
Lys His Leu Tyr Thr Gln Ser Leu Pro Thr Gly Asp Tyr Leu Tyr Asn
    690                 695                 700                 
Phe Thr Tyr Thr Gly Asp Gly Asp Ile Thr Leu Ile Thr Asp Asn Asn
705                 710                 715                 720 
Gly Asn Met Val Asn Val Arg Arg Asp Ser Thr Gly Met Pro Leu Trp
                725                 730                 735     
Leu Val Val Pro Asp Gly Gln Val Tyr Trp Val Thr Met Gly Thr Asn
            740                 745                 750         
Ser Ala Leu Lys Ser Val Thr Thr Gln Gly His Glu Leu Ala Met Met
        755                 760                 765             
Thr Tyr His Gly Asn Ser Gly Leu Leu Ala Thr Lys Ser Asn Glu Asn
    770                 775                 780                 
Gly Trp Thr Thr Phe Tyr
785                 790 


<210> 6997
<211> 649
<212> PRT
<213> Homo sapiens

<400> 6997
Arg Ser Leu Pro Arg Gly Arg Ala His Gly Arg Thr Glu Arg Arg Lys
 1               5                  10                  15      
Gly Trp Arg Cys Asp Ser Arg Ala Gly Ala Leu Ala Ser Pro Pro Arg
            20                  25                  30          
Ala Leu Ala Ala Gly Pro Gly Glu Met Glu Ser Thr Ala Tyr Pro Leu
        35                  40                  45              
Asn Leu Ser Leu Lys Glu Glu Glu Glu Glu Glu Glu Ile Gln Ser Arg
    50                  55                  60                  
Glu Leu Glu Asp Gly Pro Ala Asp Met Gln Lys Val Arg Ile Cys Ser
65                  70                  75                  80  
Glu Gly Gly Trp Val Pro Ala Leu Phe Asp Glu Val Ala Ile Tyr Phe
                85                  90                  95      
Ser Asp Glu Glu Trp Glu Val Leu Thr Glu Gln Gln Lys Ala Leu Tyr
            100                 105                 110         
Arg Glu Val Met Arg Met Asn Tyr Glu Thr Val Leu Ser Leu Glu Phe
        115                 120                 125             
Pro Phe Pro Lys Pro Asp Met Ile Thr Arg Leu Glu Gly Glu Glu Glu
    130                 135                 140                 
Ser Gln Asn Ser Asp Glu Trp Gln Leu Gln Gly Gly Thr Ser Ala Glu
145                 150                 155                 160 
Asn Glu Glu Ser Asp Val Lys Pro Pro Asp Trp Pro Asn Pro Met Asn
                165                 170                 175     
Ala Thr Ser Gln Phe Pro Gln Pro Gln His Phe Asp Ser Phe Gly Leu
            180                 185                 190         
Arg Leu Pro Arg Asp Ile Thr Glu Leu Pro Glu Trp Ser Glu Gly Tyr
        195                 200                 205             
Pro Phe Tyr Met Ala Met Gly Phe Pro Gly Tyr Asp Leu Ser Ala Asp
    210                 215                 220                 
Asp Ile Ala Gly Lys Phe Gln Phe Ser Arg Gly Met Arg Arg Ser Tyr
225                 230                 235                 240 
Asp Ala Gly Phe Lys Leu Met Val Val Glu Tyr Ala Glu Ser Thr Asn
                245                 250                 255     
Asn Cys Gln Ala Ala Lys Gln Phe Gly Val Leu Glu Lys Asn Val Arg
            260                 265                 270         
Asp Trp Arg Lys Val Lys Pro Gln Leu Gln Asn Ala His Ala Met Arg
        275                 280                 285             
Arg Ala Phe Arg Gly Pro Lys Asn Gly Arg Phe Ala Leu Val Asp Gln
    290                 295                 300                 
Arg Val Ala Glu Tyr Val Arg Tyr Met Gln Ala Lys Gly Asp Pro Ile
305                 310                 315                 320 
Thr Arg Glu Ala Met Gln Leu Lys Ala Leu Glu Ile Ala Gln Glu Met
                325                 330                 335     
Asn Ile Pro Glu Lys Gly Phe Lys Ala Ser Leu Gly Trp Cys Arg Arg
            340                 345                 350         
Met Met Arg Arg Tyr Asp Leu Ser Leu Arg His Lys Val Pro Val Pro
        355                 360                 365             
Gln His Leu Pro Glu Asp Leu Thr Glu Lys Leu Val Thr Tyr Gln Arg
    370                 375                 380                 
Ser Val Leu Ala Leu Arg Arg Ala His Asp Tyr Glu Val Ala Gln Met
385                 390                 395                 400 
Gly Asn Ala Asp Glu Thr Pro Ile Cys Leu Glu Val Pro Ser Arg Val
                405                 410                 415     
Thr Val Asp Asn Gln Gly Glu Lys Pro Val Leu Val Lys Thr Pro Gly
            420                 425                 430         
Arg Glu Lys Leu Lys Ile Thr Ala Met Leu Gly Val Leu Ala Asp Gly
        435                 440                 445             
Arg Lys Leu Pro Pro Tyr Ile Ile Leu Arg Gly Thr Tyr Ile Pro Pro
    450                 455                 460                 
Gly Lys Phe Pro Ser Gly Met Glu Ile Arg Cys His Arg Tyr Gly Trp
465                 470                 475                 480 
Met Thr Glu Asp Leu Met Gln Asp Trp Leu Glu Val Val Trp Arg Arg
                485                 490                 495     
Arg Thr Gly Ala Val Pro Lys Gln Arg Gly Met Leu Ile Leu Asn Gly
            500                 505                 510         
Phe Arg Gly His Ala Thr Asp Ser Val Lys Asn Ser Met Glu Ser Met
        515                 520                 525             
Asn Thr Asp Met Val Ile Ile Pro Gly Gly Leu Thr Ser Gln Leu Gln
    530                 535                 540                 
Val Leu Asp Val Val Val Tyr Lys Pro Leu Asn Asp Ser Val Arg Ala
545                 550                 555                 560 
Gln Tyr Ser Asn Trp Leu Leu Ala Gly Asn Leu Ala Leu Ser Pro Thr
                565                 570                 575     
Gly Asn Ala Lys Lys Pro Pro Leu Gly Leu Phe Leu Glu Trp Val Met
            580                 585                 590         
Val Ala Trp Asn Ser Ile Ser Ser Glu Ser Ile Val Gln Gly Phe Lys
        595                 600                 605             
Lys Cys His Ile Ser Ser Asn Leu Glu Glu Glu Asp Asp Val Leu Trp
    610                 615                 620                 
Glu Ile Glu Ser Glu Leu Pro Gly Gly Gly Glu Pro Pro Lys Asp Cys
625                 630                 635                 640 
Asp Thr Glu Ser Met Ala Glu Ser Asn
                645                 


<210> 6998
<211> 145
<212> PRT
<213> Homo sapiens

<400> 6998
Ala Leu Gly Gly Val Ala Glu Tyr Asp Leu Lys Glu Gly Leu Leu Val
 1               5                  10                  15      
Ser Pro Gly Ser Val Ile Met Asn Gly Ser Asn Met Ala Asn Thr Ser
            20                  25                  30          
Pro Ser Val Lys Ser Lys Glu Asp Gln Gly Leu Ser Gly His Asp Glu
        35                  40                  45              
Lys Glu Asn Pro Phe Ala Glu Tyr Met Trp Met Glu Asn Glu Glu Asp
    50                  55                  60                  
Phe Asn Arg Gln Val Glu Glu Glu Leu Gln Glu Gln Asp Phe Leu Asp
65                  70                  75                  80  
Arg Cys Phe Gln Glu Met Leu Asp Glu Glu Asp Gln Asp Trp Phe Ile
                85                  90                  95      
Pro Ser Arg Asp Leu Pro Gln Ala Met Gly Gln Leu Gln Gln Gln Leu
            100                 105                 110         
Asn Gly Leu Ser Val Ser Glu Gly His Asp Ser Glu Asp Ile Leu Ser
        115                 120                 125             
Lys Ser Asn Leu Asn Pro Asp Ala Lys Glu Phe Ile Pro Gly Glu Lys
    130                 135                 140                 
Tyr
145 


<210> 6999
<211> 431
<212> PRT
<213> Homo sapiens

<400> 6999
Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu
 1               5                  10                  15      
Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala
            20                  25                  30          
Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg
        35                  40                  45              
Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met
    50                  55                  60                  
Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala
65                  70                  75                  80  
Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu
                85                  90                  95      
Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His
            100                 105                 110         
Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met
        115                 120                 125             
Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys
    130                 135                 140                 
Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp
145                 150                 155                 160 
Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala
                165                 170                 175     
Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro
            180                 185                 190         
Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe
        195                 200                 205             
Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu
    210                 215                 220                 
Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln
225                 230                 235                 240 
Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met
                245                 250                 255     
Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val
            260                 265                 270         
Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln
        275                 280                 285             
Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser
    290                 295                 300                 
Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr
305                 310                 315                 320 
Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met
                325                 330                 335     
Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu
            340                 345                 350         
Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr
        355                 360                 365             
Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala
    370                 375                 380                 
Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser
385                 390                 395                 400 
Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys
                405                 410                 415     
Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro
            420                 425                 430     


<210> 7000
<211> 628
<212> PRT
<213> Homo sapiens

<400> 7000
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln
 1               5                  10                  15      
Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg
            20                  25                  30          
Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp
        35                  40                  45              
Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln
    50                  55                  60                  
Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser
65                  70                  75                  80  
Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp
                85                  90                  95      
Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr Asp
            100                 105                 110         
Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg Leu
        115                 120                 125             
His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg
    130                 135                 140                 
Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His
145                 150                 155                 160 
Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val
                165                 170                 175     
Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys
            180                 185                 190         
Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu
        195                 200                 205             
His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile
    210                 215                 220                 
Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly
225                 230                 235                 240 
Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu
                245                 250                 255     
Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val
            260                 265                 270         
Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala
        275                 280                 285             
Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala
    290                 295                 300                 
Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe
305                 310                 315                 320 
His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro
                325                 330                 335     
Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp
            340                 345                 350         
Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala
        355                 360                 365             
Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln
    370                 375                 380                 
Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser
385                 390                 395                 400 
Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val
                405                 410                 415     
Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr
            420                 425                 430         
Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr
        435                 440                 445             
Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu
    450                 455                 460                 
Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly
465                 470                 475                 480 
Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr
                485                 490                 495     
Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu
            500                 505                 510         
Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro
        515                 520                 525             
Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn
    530                 535                 540                 
Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly
545                 550                 555                 560 
Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val
                565                 570                 575     
Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu
            580                 585                 590         
Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu
        595                 600                 605             
Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val
    610                 615                 620                 
Glu Leu Ser Ala
625             


<210> 7001
<211> 645
<212> PRT
<213> Homo sapiens

<400> 7001
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln
 1               5                  10                  15      
Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg
            20                  25                  30          
Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp
        35                  40                  45              
Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln
    50                  55                  60                  
Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Gln Pro Leu His Phe
65                  70                  75                  80  
Leu Thr Trp Asp Thr Cys Tyr Phe His Tyr Leu Val Pro Thr Pro Met
                85                  90                  95      
Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln
            100                 105                 110         
Asp Ser Gly Asp Leu Gly Pro Leu Thr Arg Thr Leu Gln Trp Asp Thr
        115                 120                 125             
Asp Pro Ser Val Leu Gln Leu Gln Ser Asp Ser Glu Leu Gly Arg Arg
    130                 135                 140                 
Leu His Lys Leu Gly Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro
145                 150                 155                 160 
Arg Glu Val Val Ser Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr
                165                 170                 175     
His Gln Ser Glu Glu Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys
            180                 185                 190         
Val Gly Gln Asp Ser Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val
        195                 200                 205             
Lys Glu Ala Pro Pro Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile
    210                 215                 220                 
Leu His Ser Glu Glu Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val
225                 230                 235                 240 
Ile Glu Arg Ala Leu Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser
                245                 250                 255     
Gly Arg Glu Leu Glu Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn
            260                 265                 270         
Leu Ser Phe Asn Arg Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg
        275                 280                 285             
Val Val Thr Cys Met Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val
    290                 295                 300                 
Ala Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val
305                 310                 315                 320 
Ala Leu Val Trp Asn Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val
                325                 330                 335     
Phe His Cys Gln Ser Ser Val Met Ser Val Cys Phe Ala Arg Phe His
            340                 345                 350         
Pro Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp
        355                 360                 365             
Asp Asn Arg Ser His Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser
    370                 375                 380                 
Ala Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr
385                 390                 395                 400 
Gln Asn Ala His Asn Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys
                405                 410                 415     
Ser Trp Ser Leu Asp Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu
            420                 425                 430         
Val Tyr Asn Lys Ser Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro
        435                 440                 445             
Thr Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val
    450                 455                 460                 
Tyr Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe
465                 470                 475                 480 
Glu Gly His Gln Gly Pro Val Thr Gly Ile Asn Cys His Met Ala Val
                485                 490                 495     
Gly Pro Ile Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp
            500                 505                 510         
Thr Val Lys Leu Trp Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe
        515                 520                 525             
Glu Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Val His
    530                 535                 540                 
Pro Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp
545                 550                 555                 560 
Asn Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu
                565                 570                 575     
Gly Ala Ser Ala Leu Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu
            580                 585                 590         
Val Ala Val Gly Asp Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly
        595                 600                 605             
Glu Leu Ala Val Pro His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr
    610                 615                 620                 
Leu Val Glu Ile Arg Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr
625                 630                 635                 640 
Val Glu Leu Ser Ala
                645 


<210> 7002
<211> 608
<212> PRT
<213> Homo sapiens

<400> 7002
Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln
 1               5                  10                  15      
Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg
            20                  25                  30          
Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp
        35                  40                  45              
Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln
    50                  55                  60                  
Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser
65                  70                  75                  80  
Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp
                85                  90                  95      
Ser Gly Asp Leu Gly Pro Leu Thr Arg Arg Arg Leu His Lys Leu Gly
            100                 105                 110         
Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu Val Val Ser
        115                 120                 125             
Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln Ser Glu Glu
    130                 135                 140                 
Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val Gly Gln Asp Ser
145                 150                 155                 160 
Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys Glu Ala Pro Pro
                165                 170                 175     
Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu
            180                 185                 190         
Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu Arg Ala Leu
        195                 200                 205             
Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg Glu Leu Glu
    210                 215                 220                 
Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser Phe Asn Arg
225                 230                 235                 240 
Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val Thr Cys Met
                245                 250                 255     
Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser Tyr Asn Asn
            260                 265                 270         
Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn
        275                 280                 285             
Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser
    290                 295                 300                 
Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn Leu Val Val
305                 310                 315                 320 
Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser His
                325                 330                 335     
Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr
            340                 345                 350         
His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn
        355                 360                 365             
Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp Ser Leu Asp
    370                 375                 380                 
Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr Asn Lys Ser
385                 390                 395                 400 
Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly Asp Val Asn
                405                 410                 415     
Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr Ala Cys Arg
            420                 425                 430         
His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly His Gln Gly
        435                 440                 445             
Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro Ile Asp Phe
    450                 455                 460                 
Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp
465                 470                 475                 480 
Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp
                485                 490                 495     
Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala Leu Phe Ala
            500                 505                 510         
Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp
        515                 520                 525             
Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala Ser Ala Leu
    530                 535                 540                 
Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val Ala Val Gly Asp
545                 550                 555                 560 
Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu Leu Ala Val Pro
                565                 570                 575     
His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu Val Glu Ile Arg
            580                 585                 590         
Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val Glu Leu Ser Ala
        595                 600                 605             


<210> 7003
<211> 1781
<212> PRT
<213> Homo sapiens

<400> 7003
Met Thr Thr Tyr Arg Ala Ile Pro Ser Asp Gly Val Asp Leu Ala Ala
 1               5                  10                  15      
Ser Cys Gly Ala Arg Val Gly Asp Val Leu Pro Gly Pro His Thr Gly
            20                  25                  30          
Asp Tyr Ala Pro Leu Gly Phe Trp Ala Gln Asn Gly Ser Met Ser Gln
        35                  40                  45              
Pro Leu Gly Glu Ser Pro Ala Thr Ala Thr Ala Thr Ala Thr Ala Thr
    50                  55                  60                  
Thr Arg Pro Ser Pro Thr Thr Pro Ala Met Pro Lys Met Gly Val Arg
65                  70                  75                  80  
Ala Arg Val Ala Asp Trp Pro Pro Lys Arg Glu Ala Leu Arg Glu His
                85                  90                  95      
Ser Asn Pro Ser Pro Ser Gln Asp Thr Asp Gly Thr Lys Ala Thr Lys
            100                 105                 110         
Met Ala His Ser Met Arg Ser Ile Gln Asn Gly Gln Pro Pro Thr Ser
        115                 120                 125             
Thr Pro Ala Ser Ser Gly Ser Lys Ala Phe His Arg Leu Ser Arg Arg
    130                 135                 140                 
Arg Ser Lys Asp Val Glu Phe Gln Asp Gly Trp Pro Arg Ser Pro Gly
145                 150                 155                 160 
Arg Ala Phe Leu Pro Leu Arg His Arg Ser Ser Ser Glu Ile Thr Leu
                165                 170                 175     
Ser Glu Cys Asp Ala Glu Asp Ala Gly Glu Pro Arg Gly Ala Arg His
            180                 185                 190         
Thr Gly Ala Leu Pro Leu Phe Arg Glu Tyr Gly Ser Thr Ser Ser Ile
        195                 200                 205             
Asp Val Gln Gly Met Pro Glu Gln Ser Phe Phe Asp Ile Leu Asn Glu
    210                 215                 220                 
Phe Arg Ser Glu Gln Pro Asp Ala Arg Gly Cys Gln Ala Leu Thr Glu
225                 230                 235                 240 
Leu Leu Arg Ala Asp Pro Gly Pro His Leu Met Gly Gly Gly Gly Gly
                245                 250                 255     
Ala Lys Gly Asp Ser His Asn Gly Gln Pro Ala Lys Asp Ser Leu Leu
            260                 265                 270         
Pro Leu Gln Pro Thr Lys Glu Lys Glu Lys Ala Arg Lys Lys Pro Ala
        275                 280                 285             
Arg Gly Leu Gly Gly Gly Asp Thr Val Asp Ser Ser Ile Phe Arg Lys
    290                 295                 300                 
Leu Arg Ser Ser Lys Pro Glu Gly Glu Ala Gly Arg Ser Pro Gly Glu
305                 310                 315                 320 
Ala Asp Glu Gly Arg Ser Pro Pro Glu Ala Ser Arg Pro Trp Val Cys
                325                 330                 335     
Gln Lys Ser Phe Ala His Phe Asp Val Gln Ser Met Leu Phe Asp Leu
            340                 345                 350         
Asn Glu Ala Ala Ala Asn Arg Val Ser Val Ser Gln Arg Arg Asn Thr
        355                 360                 365             
Thr Thr Gly Ala Ser Ala Ala Ser Ala Ala Ser Ala Met Ala Ser Leu
    370                 375                 380                 
Thr Ala Ser Arg Ala His Ser Leu Gly Gly Leu Asp Pro Ala Phe Thr
385                 390                 395                 400 
Ser Thr Glu Asp Leu Asn Cys Lys Glu Asn Leu Glu Gln Asp Leu Gly
                405                 410                 415     
Asp Asp Asn Ser Asn Asp Leu Leu Leu Ser Cys Pro His Phe Arg Asn
            420                 425                 430         
Glu Ile Gly Gly Glu Cys Glu Arg Asn Val Ser Phe Ser Arg Ala Ser
        435                 440                 445             
Val Gly Ser Pro Ser Ser Gly Glu Gly His Leu Ala Glu Pro Ala Leu
    450                 455                 460                 
Ser Ala Tyr Arg Thr Asn Ala Ser Ile Ser Val Leu Glu Val Pro Lys
465                 470                 475                 480 
Glu Gln Gln Arg Thr Gln Ser Arg Pro Arg Gln Tyr Ser Ile Glu His
                485                 490                 495     
Val Asp Leu Gly Ala Arg Tyr Tyr Gln Asp Tyr Phe Val Gly Lys Glu
            500                 505                 510         
His Ala Asn Tyr Phe Gly Val Asp Glu Lys Leu Gly Pro Val Ala Val
        515                 520                 525             
Ser Ile Lys Arg Glu Lys Leu Glu Asp His Lys Glu His Gly Pro Gln
    530                 535                 540                 
Tyr Gln Tyr Arg Ile Ile Phe Arg Thr Arg Glu Leu Ile Thr Leu Arg
545                 550                 555                 560 
Gly Ser Ile Leu Glu Asp Ala Thr Pro Thr Ala Thr Lys His Gly Thr
                565                 570                 575     
Gly Arg Gly Leu Pro Leu Lys Asp Ala Leu Glu Tyr Val Ile Pro Glu
            580                 585                 590         
Leu Asn Ile His Cys Leu Arg Leu Ala Leu Asn Thr Pro Lys Val Thr
        595                 600                 605             
Glu Gln Leu Leu Lys Leu Asp Glu Gln Gly Leu Cys Arg Lys His Lys
    610                 615                 620                 
Val Gly Ile Leu Tyr Cys Lys Ala Gly Gln Ser Ser Glu Glu Glu Met
625                 630                 635                 640 
Tyr Asn Asn Glu Glu Ala Gly Pro Ala Phe Glu Glu Phe Leu Ser Leu
                645                 650                 655     
Ile Gly Glu Lys Val Cys Leu Lys Gly Phe Thr Lys Tyr Ala Ala Gln
            660                 665                 670         
Leu Asp Val Lys Thr Asp Ser Thr Gly Thr His Ser Leu Tyr Thr Met
        675                 680                 685             
Tyr Gln Asp Tyr Glu Ile Met Phe His Val Ser Thr Leu Leu Pro Tyr
    690                 695                 700                 
Thr Pro Asn Asn Arg Gln Gln Leu Leu Arg Lys Arg His Ile Gly Asn
705                 710                 715                 720 
Asp Ile Val Thr Ile Ile Phe Gln Glu Pro Gly Ala Leu Pro Phe Thr
                725                 730                 735     
Pro Lys Asn Ile Arg Ser His Phe Gln His Val Phe Ile Ile Val Arg
            740                 745                 750         
Val His Asn Pro Cys Thr Asp Asn Val Cys Tyr Ser Met Ala Val Thr
        755                 760                 765             
Arg Ser Lys Asp Ala Pro Pro Phe Gly Pro Pro Ile Pro Ser Gly Thr
    770                 775                 780                 
Thr Phe Arg Lys Ser Asp Val Phe Arg Asp Phe Leu Leu Ala Lys Val
785                 790                 795                 800 
Ile Asn Ala Glu Asn Ala Ala His Lys Ser Asp Lys Phe His Thr Met
                805                 810                 815     
Ala Thr Arg Thr Arg Gln Glu Tyr Leu Lys Asp Leu Ala Glu Asn Cys
            820                 825                 830         
Val Ser Asn Thr Pro Ile Asp Ser Thr Gly Lys Phe Asn Leu Ile Ser
        835                 840                 845             
Leu Thr Ser Lys Lys Lys Glu Lys Thr Lys Ala Arg Ala Gly Ala Glu
    850                 855                 860                 
Gln His Ser Ala Gly Ala Ile Ala Trp Arg Val Val Ala Gln Asp Tyr
865                 870                 875                 880 
Ala Gln Gly Val Glu Ile Asp Cys Ile Leu Gly Ile Ser Asn Glu Phe
                885                 890                 895     
Val Val Leu Leu Asp Leu Arg Thr Lys Glu Val Val Phe Asn Cys Tyr
            900                 905                 910         
Cys Gly Asp Val Ile Gly Trp Thr Pro Asp Ser Ser Thr Leu Lys Ile
        915                 920                 925             
Phe Tyr Gly Arg Gly Asp His Ile Phe Leu Gln Ala Thr Glu Gly Ser
    930                 935                 940                 
Val Glu Asp Ile Arg Glu Ile Val Gln Arg Leu Lys Val Met Thr Ser
945                 950                 955                 960 
Gly Trp Glu Thr Val Asp Met Thr Leu Arg Arg Asn Gly Leu Gly Gln
                965                 970                 975     
Leu Gly Phe His Val Lys Tyr Asp Gly Thr Val Ala Glu Val Glu Asp
            980                 985                 990         
Tyr Gly Phe Ala Trp Gln Ala Gly Leu Arg Gln Gly Ser Arg Leu Val
        995                 1000                1005            
Glu Ile Cys Lys Val Ala Val Val Thr Leu Thr His Asp Gln Met Ile
    1010                1015                1020                
Asp Leu Leu Arg Thr Ser Val Thr Val Lys Val Val Ile Ile Pro Pro
1025                1030                1035                1040
Phe Glu Asp Gly Thr Pro Arg Arg Gly Trp Pro Glu Thr Tyr Asp Met
                1045                1050                1055    
Asn Thr Ser Glu Pro Lys Thr Glu Gln Glu Ser Ile Thr Pro Gly Gly
            1060                1065                1070        
Arg Pro Pro Tyr Arg Ser Asn Ala Pro Trp Gln Trp Ser Gly Pro Ala
        1075                1080                1085            
Ser His Asn Ser Leu Pro Ala Ser Lys Trp Ala Thr Pro Thr Thr Pro
    1090                1095                1100                
Gly His Ala Gln Ser Leu Ser Arg Pro Leu Lys Gln Thr Pro Ile Val
1105                1110                1115                1120
Pro Phe Arg Glu Ser Gln Pro Leu His Ser Lys Arg Pro Val Ser Phe
                1125                1130                1135    
Pro Glu Thr Pro Tyr Thr Val Ser Pro Ala Gly Ala Asp Arg Val Pro
            1140                1145                1150        
Pro Tyr Arg Gln Pro Ser Gly Ser Phe Ser Thr Pro Gly Ser Ala Thr
        1155                1160                1165            
Tyr Val Arg Tyr Lys Pro Ser Pro Glu Arg Tyr Thr Ala Ala Pro His
    1170                1175                1180                
Pro Leu Leu Ser Leu Asp Pro His Phe Ser His Asp Gly Thr Ser Ser
1185                1190                1195                1200
Gly Asp Ser Ser Ser Gly Gly Leu Thr Ser Gln Glu Ser Thr Met Glu
                1205                1210                1215    
Arg Gln Lys Pro Glu Pro Leu Trp His Val Pro Ala Gln Ala Arg Leu
            1220                1225                1230        
Ser Ala Ile Ala Gly Ser Ser Gly Asn Lys His Pro Ser Arg Gln Asp
        1235                1240                1245            
Ala Ala Gly Lys Asp Ser Pro Asn Arg His Ser Lys Gly Glu Pro Gln
    1250                1255                1260                
Tyr Ser Ser His Ser Ser Ser Asn Thr Leu Ser Ser Asn Ala Ser Ser
1265                1270                1275                1280
Ser His Ser Asp Asp Arg Trp Phe Asp Pro Leu Asp Pro Leu Glu Pro
                1285                1290                1295    
Glu Gln Asp Pro Leu Ser Lys Gly Gly Ser Ser Asp Ser Gly Ile Asp
            1300                1305                1310        
Thr Thr Leu Tyr Thr Ser Ser Pro Ser Cys Met Ser Leu Ala Lys Ala
        1315                1320                1325            
Pro Arg Pro Ala Lys Pro His Lys Pro Pro Gly Ser Met Gly Leu Cys
    1330                1335                1340                
Gly Gly Gly Arg Glu Ala Ala Gly Arg Ser His His Ala Asp Arg Arg
1345                1350                1355                1360
Arg Glu Val Ser Pro Ala Pro Ala Val Ala Gly Gln Ser Lys Gly Tyr
                1365                1370                1375    
Arg Pro Lys Leu Tyr Ser Ser Gly Ser Ser Thr Pro Thr Gly Leu Ala
            1380                1385                1390        
Gly Gly Ser Arg Asp Pro Pro Arg Gln Pro Ser Asp Met Gly Ser Arg
        1395                1400                1405            
Val Gly Tyr Pro Ala Gln Val Tyr Lys Thr Ala Ser Ala Glu Thr Pro
    1410                1415                1420                
Arg Pro Ser Gln Leu Ala Gln Pro Ser Pro Phe Gln Leu Ser Ala Ser
1425                1430                1435                1440
Val Pro Lys Ser Phe Phe Ser Lys Gln Pro Val Arg Asn Lys His Pro
                1445                1450                1455    
Thr Gly Trp Lys Arg Thr Glu Glu Pro Pro Pro Arg Pro Leu Pro Phe
            1460                1465                1470        
Ser Asp Pro Lys Lys Gln Val Asp Thr Asn Thr Lys Asn Val Phe Gly
        1475                1480                1485            
Gln Pro Arg Leu Arg Ala Ser Leu Arg Asp Leu Arg Ser Pro Arg Lys
    1490                1495                1500                
Asn Tyr Lys Ser Thr Ile Glu Asp Asp Leu Lys Lys Leu Ile Ile Met
1505                1510                1515                1520
Asp Asn Leu Gly Pro Glu Gln Glu Arg Asp Thr Gly Gln Ser Pro Gln
                1525                1530                1535    
Lys Gly Leu Gln Arg Thr Leu Ser Asp Glu Ser Leu Cys Ser Gly Arg
            1540                1545                1550        
Arg Glu Pro Ser Phe Ala Ser Pro Ala Gly Leu Glu Pro Gly Leu Pro
        1555                1560                1565            
Ser Asp Val Leu Phe Thr Ser Thr Cys Ala Phe Pro Ser Ser Thr Leu
    1570                1575                1580                
Pro Ala Arg Arg Gln His Gln His Pro His Pro Pro Val Gly Pro Gly
1585                1590                1595                1600
Ala Thr Pro Ala Ala Gly Ser Gly Phe Pro Glu Lys Lys Ser Thr Ile
                1605                1610                1615    
Ser Ala Ser Glu Leu Ser Leu Ala Asp Gly Arg Asp Arg Pro Leu Arg
            1620                1625                1630        
Arg Leu Asp Pro Gly Leu Met Pro Leu Pro Asp Thr Ala Ala Gly Leu
        1635                1640                1645            
Glu Trp Ser Ser Leu Val Asn Ala Ala Lys Ala Tyr Glu Val Gln Arg
    1650                1655                1660                
Ala Val Ser Leu Phe Ser Leu Asn Asp Pro Ala Leu Ser Pro Asp Ile
1665                1670                1675                1680
Pro Pro Ala His Ser Pro Val His Ser His Leu Ser Leu Glu Arg Gly
                1685                1690                1695    
Pro Pro Thr Pro Arg Thr Thr Pro Thr Met Ser Glu Glu Pro Pro Leu
            1700                1705                1710        
Asp Leu Thr Gly Lys Val Tyr Gln Leu Glu Val Met Leu Lys Gln Leu
        1715                1720                1725            
His Thr Asp Leu Gln Lys Glu Lys Gln Asp Lys Val Val Leu Gln Ser
    1730                1735                1740                
Glu Val Ala Ser Leu Arg Gln Asn Asn Gln Arg Leu Gln Glu Glu Ser
1745                1750                1755                1760
Gln Ala Ala Ser Glu Gln Leu Arg Lys Phe Ala Glu Ile Phe Cys Arg
                1765                1770                1775    
Glu Lys Lys Glu Leu
            1780    


<210> 7004
<211> 353
<212> PRT
<213> Homo sapiens

<400> 7004
Met Thr Thr Tyr Arg Ala Ile Pro Ser Asp Gly Val Asp Leu Ala Ala
 1               5                  10                  15      
Ser Cys Gly Ala Arg Val Gly Asp Val Leu Pro Gly Pro His Thr Gly
            20                  25                  30          
Asp Tyr Ala Pro Leu Gly Phe Trp Ala Gln Asn Gly Ser Met Ser Gln
        35                  40                  45              
Pro Leu Gly Glu Ser Pro Ala Thr Ala Thr Ala Thr Ala Thr Ala Thr
    50                  55                  60                  
Thr Arg Pro Ser Pro Thr Thr Pro Ala Met Pro Lys Met Gly Val Arg
65                  70                  75                  80  
Ala Arg Val Ala Asp Trp Pro Pro Lys Arg Glu Ala Leu Arg Glu His
                85                  90                  95      
Ser Asn Pro Ser Pro Ser Gln Asp Thr Asp Gly Thr Lys Ala Thr Lys
            100                 105                 110         
Met Ala His Ser Met Arg Ser Ile Gln Asn Gly Gln Pro Pro Thr Ser
        115                 120                 125             
Thr Pro Ala Ser Ser Gly Ser Lys Ala Phe His Arg Leu Ser Arg Arg
    130                 135                 140                 
Arg Ser Lys Asp Val Glu Phe Gln Asp Gly Trp Pro Arg Ser Pro Gly
145                 150                 155                 160 
Arg Ala Phe Leu Pro Leu Arg His Arg Ser Ser Ser Glu Ile Thr Leu
                165                 170                 175     
Ser Glu Cys Asp Ala Glu Asp Ala Gly Glu Pro Arg Gly Ala Arg His
            180                 185                 190         
Thr Gly Ala Leu Pro Leu Phe Arg Glu Tyr Gly Ser Thr Ser Ser Ile
        195                 200                 205             
Asp Val Gln Gly Met Pro Glu Gln Ser Phe Phe Asp Ile Leu Asn Glu
    210                 215                 220                 
Phe Arg Ser Glu Gln Pro Asp Ala Arg Gly Cys Gln Ala Leu Thr Glu
225                 230                 235                 240 
Leu Leu Arg Ala Asp Pro Gly Pro His Leu Met Gly Gly Gly Gly Gly
                245                 250                 255     
Ala Lys Gly Asp Ser His Asn Gly Gln Pro Ala Lys Asp Ser Leu Leu
            260                 265                 270         
Pro Leu Gln Pro Thr Lys Glu Lys Glu Lys Ala Arg Lys Lys Pro Ala
        275                 280                 285             
Arg Gly Leu Gly Gly Gly Asp Thr Val Asp Ser Ser Ile Phe Arg Lys
    290                 295                 300                 
Leu Arg Ser Ser Lys Pro Glu Gly Glu Ala Gly Arg Ser Pro Gly Glu
305                 310                 315                 320 
Ala Asp Glu Gly Arg Ser Pro Pro Glu Ala Ser Arg Pro Trp Val Cys
                325                 330                 335     
Gln Lys Ser Phe Ala His Phe Asp Val Gln Ser Met Leu Phe Asp Leu
            340                 345                 350         
Asn
    


<210> 7005
<211> 318
<212> PRT
<213> Homo sapiens

<400> 7005
Met Pro Asn Ile Lys Ile Phe Ser Gly Ser Ser His Gln Asp Leu Ser
 1               5                  10                  15      
Gln Lys Ile Ala Asp Arg Leu Gly Leu Glu Leu Gly Lys Val Val Thr
            20                  25                  30          
Lys Lys Phe Ser Asn Gln Glu Thr Cys Val Glu Ile Asp Glu Ser Val
        35                  40                  45              
Arg Gly Glu Asp Val Tyr Ile Val Gln Ser Gly Cys Gly Glu Ile Asn
    50                  55                  60                  
Asp Ser Leu Met Glu Leu Leu Ile Met Ile Asn Ala Cys Lys Ile Ala
65                  70                  75                  80  
Ser Ala Ser Arg Val Thr Ala Val Ile Pro Cys Phe Pro Tyr Ala Arg
                85                  90                  95      
Gln Asp Lys Lys Asp Lys Ser Arg Ser Pro Ile Ser Ala Lys Leu Val
            100                 105                 110         
Ala Asn Met Leu Ser Ile Ala Gly Ala Asp His Ile Ile Thr Met Asp
        115                 120                 125             
Leu His Ala Ser Gln Ile Gln Gly Phe Phe Asp Ile Pro Val Asp Asn
    130                 135                 140                 
Leu Tyr Ala Glu Pro Thr Val Leu Lys Trp Ile Arg Glu Asn Ile Pro
145                 150                 155                 160 
Glu Trp Lys Asn Cys Ile Ile Val Ser Pro Asp Ala Gly Gly Ala Lys
                165                 170                 175     
Arg Val Thr Ser Ile Ala Asp Gln Leu Asn Val Asp Phe Ala Leu Ile
            180                 185                 190         
His Lys Glu Arg Lys Lys Ala Asn Glu Val Asp Cys Ile Val Leu Val
        195                 200                 205             
Gly Asp Val Asn Asp Arg Val Ala Ile Leu Val Asp Asp Met Ala Asp
    210                 215                 220                 
Thr Cys Val Thr Ile Cys Leu Ala Ala Asp Lys Leu Leu Ser Ala Gly
225                 230                 235                 240 
Ala Thr Arg Val Tyr Ala Ile Leu Thr His Gly Ile Phe Ser Gly Pro
                245                 250                 255     
Ala Ile Ser Arg Ile Asn Thr Ala Cys Phe Glu Ala Val Val Val Thr
            260                 265                 270         
Asn Thr Ile Pro Gln Asp Glu Lys Met Lys His Cys Ser Lys Ile Arg
        275                 280                 285             
Val Ile Asp Ile Ser Met Ile Leu Ala Glu Ala Ile Arg Arg Thr His
    290                 295                 300                 
Asn Gly Glu Ser Val Ser Tyr Leu Phe Ser His Val Pro Leu
305                 310                 315             


<210> 7006
<211> 349
<212> PRT
<213> Homo sapiens

<400> 7006
Met Gln Pro Met Ile Lys Gln Met Ser Leu Ser Thr Tyr Arg Asp Gln
 1               5                  10                  15      
Ser Lys Gln Thr Leu Asn Pro Leu Ala Ile Asp Gln Leu Ala Lys Thr
            20                  25                  30          
Pro Asn Ile Lys Ile Phe Ser Gly Ser Ser His Gln Asp Leu Ser Gln
        35                  40                  45              
Lys Ile Ala Asp Arg Leu Gly Leu Glu Leu Gly Lys Val Val Thr Lys
    50                  55                  60                  
Lys Phe Ser Asn Gln Glu Thr Cys Val Glu Ile Asp Glu Ser Val Arg
65                  70                  75                  80  
Gly Glu Asp Val Tyr Ile Val Gln Ser Gly Cys Gly Glu Ile Asn Asp
                85                  90                  95      
Ser Leu Met Glu Leu Leu Ile Met Ile Asn Ala Cys Lys Ile Ala Ser
            100                 105                 110         
Ala Ser Arg Val Thr Ala Val Ile Pro Cys Phe Pro Tyr Ala Arg Gln
        115                 120                 125             
Asp Lys Lys Asp Lys Ser Arg Ser Pro Ile Ser Ala Lys Leu Val Ala
    130                 135                 140                 
Asn Met Leu Ser Ile Ala Gly Ala Asp His Ile Ile Thr Met Asp Leu
145                 150                 155                 160 
His Ala Ser Gln Ile Gln Gly Phe Phe Asp Ile Pro Val Asp Asn Leu
                165                 170                 175     
Tyr Ala Glu Pro Thr Val Leu Lys Trp Ile Arg Glu Asn Ile Pro Glu
            180                 185                 190         
Trp Lys Asn Cys Ile Ile Val Ser Pro Asp Ala Gly Gly Ala Lys Arg
        195                 200                 205             
Val Thr Ser Ile Ala Asp Gln Leu Asn Val Asp Phe Ala Leu Ile His
    210                 215                 220                 
Lys Glu Arg Lys Lys Ala Asn Glu Val Asp Cys Ile Val Leu Val Gly
225                 230                 235                 240 
Asp Val Asn Asp Arg Val Ala Ile Leu Val Asp Asp Met Ala Asp Thr
                245                 250                 255     
Cys Val Thr Ile Cys Leu Ala Ala Asp Lys Leu Leu Ser Ala Gly Ala
            260                 265                 270         
Thr Arg Val Tyr Ala Ile Leu Thr His Gly Ile Phe Ser Gly Pro Ala
        275                 280                 285             
Ile Ser Arg Ile Asn Thr Ala Cys Phe Glu Ala Val Val Val Thr Asn
    290                 295                 300                 
Thr Ile Pro Gln Asp Asp Lys Met Lys His Cys Ser Lys Ile Arg Val
305                 310                 315                 320 
Ile Asp Ile Ser Met Ile Leu Ala Glu Ala Ile Arg Arg Thr His Asn
                325                 330                 335     
Gly Glu Ser Val Ser Tyr Leu Phe Ser His Val Pro Leu
            340                 345                 


<210> 7007
<211> 726
<212> PRT
<213> Homo sapiens

<400> 7007
Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln
 1               5                  10                  15      
Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys
            20                  25                  30          
Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr
        35                  40                  45              
Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His
    50                  55                  60                  
Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr
65                  70                  75                  80  
Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn
                85                  90                  95      
Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro
            100                 105                 110         
Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg
        115                 120                 125             
His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile
    130                 135                 140                 
Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr
145                 150                 155                 160 
Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly
                165                 170                 175     
Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly
            180                 185                 190         
Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser
        195                 200                 205             
Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu
    210                 215                 220                 
Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile
225                 230                 235                 240 
Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser
                245                 250                 255     
Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr
            260                 265                 270         
Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly
        275                 280                 285             
Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln
    290                 295                 300                 
Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr
305                 310                 315                 320 
Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser
                325                 330                 335     
Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly
            340                 345                 350         
Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile
        355                 360                 365             
Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser
    370                 375                 380                 
Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro
385                 390                 395                 400 
Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Asn Leu Ser Ser Ala
                405                 410                 415     
Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser Gly Leu Ile Asp Ser
            420                 425                 430         
Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala Ser Arg Cys Asp Asp
        435                 440                 445             
Lys Ser Val Glu Asn Cys Met Cys Val Leu His Asn Leu Ser Tyr Arg
    450                 455                 460                 
Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln Leu Glu Tyr Asn Ala
465                 470                 475                 480 
Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly Cys Phe Ser Asn Lys
                485                 490                 495     
Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys Pro Leu Pro Glu Glu
            500                 505                 510         
Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr His Ser Asp Ala Ile
        515                 520                 525             
Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys Lys Asp Ala Thr Leu
    530                 535                 540                 
Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr Ala Ser Lys Gly Leu
545                 550                 555                 560 
Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu Lys Glu Lys Gly Leu
                565                 570                 575     
Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn Ser Asp Val Val Arg
            580                 585                 590         
Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg His Pro Leu Leu His
        595                 600                 605             
Arg Val Met Gly Asn Gln Val Phe Pro Glu Val Thr Arg Leu Leu Thr
    610                 615                 620                 
Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp Ile Leu Ser Ser Ala
625                 630                 635                 640 
Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln Pro Gln Leu Ala Lys
                645                 650                 655     
Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile Ile Asn Leu Cys Arg
            660                 665                 670         
Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala Arg Leu Leu Leu Ser
        675                 680                 685             
Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val Leu Arg Gln Gln Gly
    690                 695                 700                 
Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly Ala Asn Ser Leu Arg
705                 710                 715                 720 
Asn Phe Thr Ser Arg Phe
                725     


<210> 7008
<211> 747
<212> PRT
<213> Homo sapiens

<400> 7008
Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln
 1               5                  10                  15      
Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys
            20                  25                  30          
Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr
        35                  40                  45              
Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His
    50                  55                  60                  
Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr
65                  70                  75                  80  
Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn
                85                  90                  95      
Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro
            100                 105                 110         
Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg
        115                 120                 125             
His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile
    130                 135                 140                 
Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr
145                 150                 155                 160 
Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly
                165                 170                 175     
Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly
            180                 185                 190         
Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser
        195                 200                 205             
Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu
    210                 215                 220                 
Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile
225                 230                 235                 240 
Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser
                245                 250                 255     
Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr
            260                 265                 270         
Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly
        275                 280                 285             
Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln
    290                 295                 300                 
Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr
305                 310                 315                 320 
Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser
                325                 330                 335     
Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly
            340                 345                 350         
Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile
        355                 360                 365             
Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser
    370                 375                 380                 
Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro
385                 390                 395                 400 
Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Lys Arg Leu Gly Met
                405                 410                 415     
Arg Glu Leu Leu Ala Leu Val Pro Gln Arg Ala Thr Ser Ser Arg Val
            420                 425                 430         
Asn Leu Ser Ser Ala Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser
        435                 440                 445             
Gly Leu Ile Asp Ser Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala
    450                 455                 460                 
Ser Arg Cys Asp Asp Lys Ser Val Glu Asn Cys Met Cys Val Leu His
465                 470                 475                 480 
Asn Leu Ser Tyr Arg Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln
                485                 490                 495     
Leu Glu Tyr Asn Ala Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly
            500                 505                 510         
Cys Phe Ser Asn Lys Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys
        515                 520                 525             
Pro Leu Pro Glu Glu Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr
    530                 535                 540                 
His Ser Asp Ala Ile Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys
545                 550                 555                 560 
Lys Asp Ala Thr Leu Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr
                565                 570                 575     
Ala Ser Lys Gly Leu Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu
            580                 585                 590         
Lys Glu Lys Gly Leu Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn
        595                 600                 605             
Ser Asp Val Val Arg Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg
    610                 615                 620                 
His Pro Leu Leu His Arg Val Met Gly Asn Gln Val Phe Pro Glu Val
625                 630                 635                 640 
Thr Arg Leu Leu Thr Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp
                645                 650                 655     
Ile Leu Ser Ser Ala Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln
            660                 665                 670         
Pro Gln Leu Ala Lys Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile
        675                 680                 685             
Ile Asn Leu Cys Arg Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala
    690                 695                 700                 
Arg Leu Leu Leu Ser Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val
705                 710                 715                 720 
Leu Arg Gln Gln Gly Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly
                725                 730                 735     
Ala Asn Ser Leu Arg Asn Phe Thr Ser Arg Phe
            740                 745         


<210> 7009
<211> 1890
<212> PRT
<213> Homo sapiens

<400> 7009
Met Val Lys Leu Ala Asn Pro Leu Tyr Thr Glu Trp Ile Leu Glu Ala
 1               5                  10                  15      
Ile Gln Lys Ile Lys Lys Gln Lys Gln Arg Pro Ser Glu Glu Arg Ile
            20                  25                  30          
Cys His Ala Val Ser Thr Ser His Gly Leu Asp Lys Lys Thr Val Ser
        35                  40                  45              
Glu Gln Leu Glu Leu Ser Val Gln Asp Gly Ser Val Leu Lys Val Thr
    50                  55                  60                  
Asn Lys Gly Leu Ala Ser Tyr Lys Asp Pro Asp Asn Pro Gly Arg Phe
65                  70                  75                  80  
Ser Ser Val Lys Pro Gly Thr Phe Pro Lys Ser Ala Lys Gly Ser Arg
                85                  90                  95      
Gly Ser Cys Asn Asp Leu Arg Asn Val Asp Trp Asn Lys Leu Leu Arg
            100                 105                 110         
Arg Ala Ile Glu Gly Leu Glu Glu Pro Asn Gly Ser Ser Leu Lys Asn
        115                 120                 125             
Ile Glu Lys Tyr Leu Arg Ser Gln Ser Asp Leu Thr Ser Thr Thr Asn
    130                 135                 140                 
Asn Pro Ala Phe Gln Gln Arg Leu Arg Leu Gly Ala Lys Arg Ala Val
145                 150                 155                 160 
Asn Asn Gly Arg Leu Leu Lys Asp Gly Pro Gln Tyr Arg Val Asn Tyr
                165                 170                 175     
Gly Ser Leu Asp Gly Lys Gly Ala Pro Gln Tyr Pro Ser Ala Phe Pro
            180                 185                 190         
Ser Ser Leu Pro Pro Val Ser Leu Leu Pro His Glu Lys Asp Gln Pro
        195                 200                 205             
Arg Ala Asp Pro Ile Pro Ile Cys Ser Phe Cys Leu Gly Thr Lys Glu
    210                 215                 220                 
Ser Asn Arg Glu Lys Lys Pro Glu Glu Leu Leu Ser Cys Ala Asp Cys
225                 230                 235                 240 
Gly Ser Ser Gly His Pro Ser Cys Leu Lys Phe Cys Pro Glu Leu Thr
                245                 250                 255     
Thr Asn Val Lys Ala Leu Arg Trp Gln Cys Ile Glu Cys Lys Thr Cys
            260                 265                 270         
Ser Ala Cys Arg Val Gln Gly Arg Asn Ala Asp Asn Met Leu Phe Cys
        275                 280                 285             
Asp Ser Cys Asp Arg Gly Phe His Met Glu Cys Cys Asp Pro Pro Leu
    290                 295                 300                 
Ser Arg Met Pro Lys Gly Met Trp Ile Cys Gln Val Cys Arg Pro Lys
305                 310                 315                 320 
Lys Lys Gly Arg Lys Leu Leu His Glu Lys Ala Ala Gln Ile Lys Arg
                325                 330                 335     
Arg Tyr Ala Lys Pro Ile Gly Arg Pro Lys Asn Lys Leu Lys Gln Arg
            340                 345                 350         
Leu Leu Ser Val Thr Ser Asp Glu Gly Ser Met Asn Ala Phe Thr Gly
        355                 360                 365             
Arg Gly Ser Pro Gly Arg Gly Gln Lys Thr Lys Val Cys Thr Thr Pro
    370                 375                 380                 
Ser Ser Gly His Ala Ala Ser Gly Lys Asp Ser Ser Ser Arg Leu Ala
385                 390                 395                 400 
Val Thr Asp Pro Thr Arg Pro Gly Ala Thr Thr Lys Ile Thr Thr Thr
                405                 410                 415     
Ser Thr Tyr Ile Ser Ala Ser Thr Leu Lys Val Asn Lys Lys Thr Lys
            420                 425                 430         
Gly Leu Ile Asp Gly Leu Thr Lys Phe Phe Thr Pro Ser Pro Asp Gly
        435                 440                 445             
Arg Arg Ser Arg Gly Glu Ile Ile Asp Phe Ser Lys His Tyr Arg Pro
    450                 455                 460                 
Arg Lys Lys Val Ser Gln Lys Gln Ser Cys Thr Ser His Val Leu Ala
465                 470                 475                 480 
Thr Asp Thr Glu Ile Lys Ile Asn Ile Lys Gln Glu Ser Ala Asp Val
                485                 490                 495     
Asn Val Ile Gly Asn Lys Asp Val Val Thr Glu Glu Asp Leu Asp Val
            500                 505                 510         
Phe Lys Gln Ala Gln Glu Leu Ser Trp Glu Lys Ile Glu Cys Glu Ser
        515                 520                 525             
Gly Val Glu Asp Cys Gly Arg Tyr Pro Ser Val Ile Glu Phe Gly Lys
    530                 535                 540                 
Tyr Glu Ile Gln Thr Trp Tyr Ser Ser Pro Tyr Pro Gln Glu Tyr Ala
545                 550                 555                 560 
Arg Leu Pro Lys Leu Tyr Leu Cys Glu Phe Cys Leu Lys Tyr Met Lys
                565                 570                 575     
Ser Lys Asn Ile Leu Leu Arg His Ser Lys Lys Cys Gly Trp Phe His
            580                 585                 590         
Pro Pro Ala Asn Glu Ile Tyr Arg Arg Lys Asp Leu Ser Val Phe Glu
        595                 600                 605             
Val Asp Gly Asn Met Ser Lys Ile Tyr Cys Gln Asn Leu Cys Leu Leu
    610                 615                 620                 
Ala Lys Leu Phe Leu Asp His Lys Thr Leu Tyr Tyr Asp Val Glu Pro
625                 630                 635                 640 
Phe Leu Phe Tyr Val Leu Thr Lys Asn Asp Glu Lys Gly Cys His Leu
                645                 650                 655     
Val Gly Tyr Leu Ser Lys Glu Lys Leu Cys Gln Gln Lys Tyr Asn Val
            660                 665                 670         
Ser Cys Ile Met Ile Met Pro Gln His Gln Arg Gln Gly Phe Gly Arg
        675                 680                 685             
Phe Leu Ile Asp Phe Ser Tyr Leu Leu Ser Arg Arg Glu Gly Gln Ala
    690                 695                 700                 
Gly Ser Pro Glu Lys Pro Leu Ser Asp Leu Gly Arg Leu Ser Tyr Leu
705                 710                 715                 720 
Ala Tyr Trp Lys Ser Val Ile Leu Glu Tyr Leu Tyr His His His Glu
                725                 730                 735     
Arg His Ile Ser Ile Lys Ala Ile Ser Arg Ala Thr Gly Met Cys Pro
            740                 745                 750         
His Asp Ile Ala Thr Thr Leu Gln His Leu His Met Ile Asp Lys Arg
        755                 760                 765             
Asp Gly Arg Phe Val Ile Ile Arg Arg Glu Lys Leu Ile Leu Ser His
    770                 775                 780                 
Met Glu Lys Leu Lys Thr Cys Ser Arg Ala Asn Glu Leu Asp Pro Asp
785                 790                 795                 800 
Ser Leu Arg Trp Thr Pro Ile Leu Ile Ser Asn Ala Ala Val Ser Glu
                805                 810                 815     
Glu Glu Arg Glu Ala Glu Lys Glu Ala Glu Arg Leu Met Glu Gln Ala
            820                 825                 830         
Ser Cys Trp Glu Lys Glu Glu Gln Glu Ile Leu Ser Thr Arg Ala Asn
        835                 840                 845             
Ser Arg Gln Ser Pro Ala Lys Val Gln Ser Lys Asn Lys Tyr Leu His
    850                 855                 860                 
Ser Pro Glu Ser Arg Pro Val Thr Gly Glu Arg Gly Gln Leu Leu Glu
865                 870                 875                 880 
Leu Ser Lys Glu Ser Ser Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu
                885                 890                 895     
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu
            900                 905                 910         
Glu Glu Glu Glu Glu Glu Glu Glu Glu Asn Ile Gln Ser Ser Pro Pro
        915                 920                 925             
Arg Leu Thr Lys Pro Gln Ser Val Ala Ile Lys Arg Lys Arg Pro Phe
    930                 935                 940                 
Val Leu Lys Lys Lys Arg Gly Arg Lys Arg Arg Arg Ile Asn Ser Ser
945                 950                 955                 960 
Val Thr Thr Glu Thr Ile Ser Glu Thr Thr Glu Val Leu Asn Glu Pro
                965                 970                 975     
Phe Asp Asn Ser Asp Glu Glu Arg Pro Met Pro Gln Leu Glu Pro Thr
            980                 985                 990         
Cys Glu Ile Glu Val Glu Glu Asp Gly Arg Lys Pro Val Leu Arg Lys
        995                 1000                1005            
Ala Phe Gln His Gln Pro Gly Lys Lys Arg Gln Thr Glu Glu Glu Glu
    1010                1015                1020                
Gly Lys Asp Asn His Cys Phe Lys Asn Ala Asp Pro Cys Arg Asn Asn
1025                1030                1035                1040
Met Asn Asp Asp Ser Ser Asn Leu Lys Glu Gly Ser Lys Asp Asn Pro
                1045                1050                1055    
Glu Pro Leu Lys Cys Lys Gln Val Trp Pro Lys Gly Thr Lys Arg Gly
            1060                1065                1070        
Leu Ser Lys Trp Arg Gln Asn Lys Glu Arg Lys Thr Gly Phe Lys Leu
        1075                1080                1085            
Asn Leu Tyr Thr Pro Pro Glu Thr Pro Met Glu Pro Asp Glu Gln Val
    1090                1095                1100                
Thr Val Glu Glu Gln Lys Glu Thr Ser Glu Gly Lys Thr Ser Pro Ser
1105                1110                1115                1120
Pro Ile Arg Ile Glu Glu Glu Val Lys Glu Thr Gly Glu Ala Leu Leu
                1125                1130                1135    
Pro Gln Glu Glu Asn Arg Arg Glu Glu Thr Cys Ala Pro Val Ser Pro
            1140                1145                1150        
Asn Thr Ser Pro Gly Glu Lys Pro Glu Asp Asp Leu Ile Lys Pro Glu
        1155                1160                1165            
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    1170                1175                1180                
Glu Gly Glu Glu Glu Glu Gly Gly Gly Asn Val Glu Lys Asp Pro Asp
1185                1190                1195                1200
Gly Ala Lys Ser Gln Glu Lys Glu Glu Pro Glu Ile Ser Thr Glu Lys
                1205                1210                1215    
Glu Asp Ser Ala Arg Leu Asp Asp His Glu Glu Glu Glu Glu Glu Asp
            1220                1225                1230        
Glu Glu Pro Ser His Asn Glu Asp His Asp Ala Asp Asp Glu Asp Asp
        1235                1240                1245            
Ser His Met Glu Ser Ala Glu Val Glu Lys Glu Glu Leu Pro Arg Glu
    1250                1255                1260                
Ser Phe Lys Glu Val Leu Glu Asn Gln Glu Thr Phe Leu Asp Leu Asn
1265                1270                1275                1280
Val Gln Pro Gly His Ser Asn Pro Glu Val Leu Met Asp Cys Gly Val
                1285                1290                1295    
Asp Leu Thr Ala Ser Cys Asn Ser Glu Pro Lys Glu Leu Ala Gly Asp
            1300                1305                1310        
Pro Glu Ala Val Pro Glu Ser Asp Glu Glu Pro Pro Pro Gly Glu Gln
        1315                1320                1325            
Ala Gln Lys Gln Asp Gln Lys Asn Ser Lys Glu Val Asp Thr Glu Phe
    1330                1335                1340                
Lys Glu Gly Asn Pro Ala Thr Met Glu Ile Asp Ser Glu Thr Val Gln
1345                1350                1355                1360
Ala Val Gln Ser Leu Thr Gln Glu Ser Ser Glu Gln Asp Asp Thr Phe
                1365                1370                1375    
Gln Asp Cys Ala Glu Thr Gln Glu Ala Cys Arg Ser Leu Gln Asn Tyr
            1380                1385                1390        
Thr Arg Ala Asp Gln Ser Pro Gln Ile Ala Thr Thr Leu Asp Asp Cys
        1395                1400                1405            
Gln Gln Ser Asp His Ser Ser Pro Val Ser Ser Val His Ser His Pro
    1410                1415                1420                
Gly Gln Ser Val Arg Ser Val Asn Ser Pro Ser Val Pro Ala Leu Glu
1425                1430                1435                1440
Asn Ser Tyr Ala Gln Ile Ser Pro Asp Gln Ser Ala Ile Ser Val Pro
                1445                1450                1455    
Ser Leu Gln Asn Met Glu Thr Ser Pro Met Met Asp Val Pro Ser Val
            1460                1465                1470        
Ser Asp His Ser Gln Gln Val Val Asp Ser Gly Phe Ser Asp Leu Gly
        1475                1480                1485            
Ser Ile Glu Ser Thr Thr Glu Asn Tyr Glu Asn Pro Ser Ser Tyr Asp
    1490                1495                1500                
Ser Thr Met Gly Gly Ser Ile Cys Gly Asn Gly Ser Ser Gln Asn Ser
1505                1510                1515                1520
Cys Ser Tyr Ser Asn Leu Thr Ser Ser Ser Leu Thr Gln Ser Ser Cys
                1525                1530                1535    
Ala Val Thr Gln Gln Met Ser Asn Ile Ser Gly Ser Cys Ser Met Leu
            1540                1545                1550        
Gln Gln Thr Ser Ile Ser Ser Pro Pro Thr Cys Ser Val Lys Ser Pro
        1555                1560                1565            
Gln Gly Cys Val Val Glu Arg Pro Pro Ser Ser Ser Gln Gln Leu Ala
    1570                1575                1580                
Gln Cys Ser Met Ala Ala Asn Phe Thr Pro Pro Met Gln Leu Ala Glu
1585                1590                1595                1600
Ile Pro Glu Thr Ser Asn Ala Asn Ile Gly Leu Tyr Glu Arg Met Gly
                1605                1610                1615    
Gln Ser Asp Phe Gly Ala Gly His Tyr Pro Gln Pro Ser Ala Thr Phe
            1620                1625                1630        
Ser Leu Ala Lys Leu Gln Gln Leu Thr Asn Thr Leu Ile Asp His Ser
        1635                1640                1645            
Leu Pro Tyr Ser His Ser Ala Ala Val Thr Ser Tyr Ala Asn Ser Ala
    1650                1655                1660                
Ser Leu Ser Thr Pro Leu Ser Asn Thr Gly Leu Val Gln Leu Ser Gln
1665                1670                1675                1680
Ser Pro His Ser Val Pro Gly Gly Pro Gln Ala Gln Ala Thr Met Thr
                1685                1690                1695    
Pro Pro Pro Asn Leu Thr Pro Pro Pro Met Asn Leu Pro Pro Pro Leu
            1700                1705                1710        
Leu Gln Arg Asn Met Ala Ala Ser Asn Ile Gly Ile Ser His Ser Gln
        1715                1720                1725            
Arg Leu Gln Thr Gln Ile Ala Ser Lys Gly His Ile Ser Met Arg Thr
    1730                1735                1740                
Lys Ser Ala Ser Leu Ser Pro Ala Ala Ala Thr His Gln Ser Gln Ile
1745                1750                1755                1760
Tyr Gly Arg Ser Gln Thr Val Ala Met Gln Gly Pro Ala Arg Thr Leu
                1765                1770                1775    
Thr Met Gln Arg Gly Met Asn Met Ser Val Asn Leu Met Pro Ala Pro
            1780                1785                1790        
Ala Tyr Asn Val Asn Ser Val Asn Met Asn Met Asn Thr Leu Asn Ala
        1795                1800                1805            
Met Asn Gly Tyr Ser Met Ser Gln Pro Met Met Asn Ser Gly Tyr His
    1810                1815                1820                
Ser Asn His Gly Tyr Met Asn Gln Thr Pro Gln Tyr Pro Met Gln Met
1825                1830                1835                1840
Gln Met Gly Met Met Gly Thr Gln Pro Tyr Ala Gln Gln Pro Met Gln
                1845                1850                1855    
Thr Pro Pro His Gly Asn Met Met Tyr Thr Ala Pro Gly His His Gly
            1860                1865                1870        
Tyr Met Asn Thr Gly Met Ser Lys Gln Ser Leu Asn Gly Ser Tyr Met
        1875                1880                1885            
Arg Arg
    1890


<210> 7010
<211> 2073
<212> PRT
<213> Homo sapiens

<400> 7010
Met Val Lys Leu Ala Asn Pro Leu Tyr Thr Glu Trp Ile Leu Glu Ala
 1               5                  10                  15      
Ile Gln Lys Ile Lys Lys Gln Lys Gln Arg Pro Ser Glu Glu Arg Ile
            20                  25                  30          
Cys His Ala Val Ser Thr Ser His Gly Leu Asp Lys Lys Thr Val Ser
        35                  40                  45              
Glu Gln Leu Glu Leu Ser Val Gln Asp Gly Ser Val Leu Lys Val Thr
    50                  55                  60                  
Asn Lys Gly Leu Ala Ser Tyr Lys Asp Pro Asp Asn Pro Gly Arg Phe
65                  70                  75                  80  
Ser Ser Val Lys Pro Gly Thr Phe Pro Lys Ser Ala Lys Gly Ser Arg
                85                  90                  95      
Gly Ser Cys Asn Asp Leu Arg Asn Val Asp Trp Asn Lys Leu Leu Arg
            100                 105                 110         
Arg Ala Ile Glu Gly Leu Glu Glu Pro Asn Gly Ser Ser Leu Lys Asn
        115                 120                 125             
Ile Glu Lys Tyr Leu Arg Ser Gln Ser Asp Leu Thr Ser Thr Thr Asn
    130                 135                 140                 
Asn Pro Ala Phe Gln Gln Arg Leu Arg Leu Gly Ala Lys Arg Ala Val
145                 150                 155                 160 
Asn Asn Gly Arg Leu Leu Lys Asp Gly Pro Gln Tyr Arg Val Asn Tyr
                165                 170                 175     
Gly Ser Leu Asp Gly Lys Gly Ala Pro Gln Tyr Pro Ser Ala Phe Pro
            180                 185                 190         
Ser Ser Leu Pro Pro Val Ser Leu Leu Pro His Glu Lys Asp Gln Pro
        195                 200                 205             
Arg Ala Asp Pro Ile Pro Ile Cys Ser Phe Cys Leu Gly Thr Lys Glu
    210                 215                 220                 
Ser Asn Arg Glu Lys Lys Pro Glu Glu Leu Leu Ser Cys Ala Asp Cys
225                 230                 235                 240 
Gly Ser Ser Gly His Pro Ser Cys Leu Lys Phe Cys Pro Glu Leu Thr
                245                 250                 255     
Thr Asn Val Lys Ala Leu Arg Trp Gln Cys Ile Glu Cys Lys Thr Cys
            260                 265                 270         
Ser Ala Cys Arg Val Gln Gly Arg Asn Ala Asp Asn Met Leu Phe Cys
        275                 280                 285             
Asp Ser Cys Asp Arg Gly Phe His Met Glu Cys Cys Asp Pro Pro Leu
    290                 295                 300                 
Ser Arg Met Pro Lys Gly Met Trp Ile Cys Gln Val Cys Arg Pro Lys
305                 310                 315                 320 
Lys Lys Gly Arg Lys Leu Leu His Glu Lys Ala Ala Gln Ile Lys Arg
                325                 330                 335     
Arg Tyr Ala Lys Pro Ile Gly Arg Pro Lys Asn Lys Leu Lys Gln Arg
            340                 345                 350         
Leu Leu Ser Val Thr Ser Asp Glu Gly Ser Met Asn Ala Phe Thr Gly
        355                 360                 365             
Arg Gly Ser Pro Gly Arg Gly Gln Lys Thr Lys Val Cys Thr Thr Pro
    370                 375                 380                 
Ser Ser Gly His Ala Ala Ser Gly Lys Asp Ser Ser Ser Arg Leu Ala
385                 390                 395                 400 
Val Thr Asp Pro Thr Arg Pro Gly Ala Thr Thr Lys Ile Thr Thr Thr
                405                 410                 415     
Ser Thr Tyr Ile Ser Ala Ser Thr Leu Lys Val Asn Lys Lys Thr Lys
            420                 425                 430         
Gly Leu Ile Asp Gly Leu Thr Lys Phe Phe Thr Pro Ser Pro Asp Gly
        435                 440                 445             
Arg Arg Ser Arg Gly Glu Ile Ile Asp Phe Ser Lys His Tyr Arg Pro
    450                 455                 460                 
Arg Lys Lys Val Ser Gln Lys Gln Ser Cys Thr Ser His Val Leu Ala
465                 470                 475                 480 
Thr Gly Thr Thr Gln Lys Leu Lys Pro Pro Pro Ser Ser Leu Pro Pro
                485                 490                 495     
Pro Thr Pro Ile Ser Gly Gln Ser Pro Ser Ser Gln Lys Ser Ser Thr
            500                 505                 510         
Ala Thr Ser Ser Pro Ser Pro Gln Ser Ser Ser Ser Gln Cys Ser Val
        515                 520                 525             
Pro Ser Leu Ser Ser Leu Thr Thr Asn Ser Gln Leu Lys Ala Leu Phe
    530                 535                 540                 
Asp Gly Leu Ser His Thr Ile Pro Leu Arg Asp Ser Leu Ala Lys Arg
545                 550                 555                 560 
Asp Thr Pro Ser Tyr Ala Pro Pro Lys Arg Met Arg Arg Lys Thr Glu
                565                 570                 575     
Leu Ser Ser Thr Ala Lys Ser Lys Ala His Phe Phe Gly Lys Arg Asp
            580                 585                 590         
Ile Arg Ser Arg Phe Ile Ser His Ser Ser Ser Ser Ser Trp Gly Met
        595                 600                 605             
Ala Arg Gly Ser Ile Phe Lys Ala Ile Ala His Phe Lys Arg Thr Thr
    610                 615                 620                 
Phe Leu Lys Lys His Arg Met Leu Gly Arg Leu Lys Tyr Lys Val Thr
625                 630                 635                 640 
Pro Gln Met Gly Thr Pro Ser Pro Gly Lys Gly Ser Leu Thr Asp Gly
                645                 650                 655     
Arg Ile Lys Pro Asp Gln Asp Asp Asp Thr Glu Ile Lys Ile Asn Ile
            660                 665                 670         
Lys Gln Glu Ser Ala Asp Val Asn Val Ile Gly Asn Lys Asp Val Val
        675                 680                 685             
Thr Glu Glu Asp Leu Asp Val Phe Lys Gln Ala Gln Glu Leu Ser Trp
    690                 695                 700                 
Glu Lys Ile Glu Cys Glu Ser Gly Val Glu Asp Cys Gly Arg Tyr Pro
705                 710                 715                 720 
Ser Val Ile Glu Phe Gly Lys Tyr Glu Ile Gln Thr Trp Tyr Ser Ser
                725                 730                 735     
Pro Tyr Pro Gln Glu Tyr Ala Arg Leu Pro Lys Leu Tyr Leu Cys Glu
            740                 745                 750         
Phe Cys Leu Lys Tyr Met Lys Ser Lys Asn Ile Leu Leu Arg His Ser
        755                 760                 765             
Lys Lys Cys Gly Trp Phe His Pro Pro Ala Asn Glu Ile Tyr Arg Arg
    770                 775                 780                 
Lys Asp Leu Ser Val Phe Glu Val Asp Gly Asn Met Ser Lys Ile Tyr
785                 790                 795                 800 
Cys Gln Asn Leu Cys Leu Leu Ala Lys Leu Phe Leu Asp His Lys Thr
                805                 810                 815     
Leu Tyr Tyr Asp Val Glu Pro Phe Leu Phe Tyr Val Leu Thr Lys Asn
            820                 825                 830         
Asp Glu Lys Gly Cys His Leu Val Gly Tyr Leu Ser Lys Glu Lys Leu
        835                 840                 845             
Cys Gln Gln Lys Tyr Asn Val Ser Cys Ile Met Ile Met Pro Gln His
    850                 855                 860                 
Gln Arg Gln Gly Phe Gly Arg Phe Leu Ile Asp Phe Ser Tyr Leu Leu
865                 870                 875                 880 
Ser Arg Arg Glu Gly Gln Ala Gly Ser Pro Glu Lys Pro Leu Ser Asp
                885                 890                 895     
Leu Gly Arg Leu Ser Tyr Leu Ala Tyr Trp Lys Ser Val Ile Leu Glu
            900                 905                 910         
Tyr Leu Tyr His His His Glu Arg His Ile Ser Ile Lys Ala Ile Ser
        915                 920                 925             
Arg Ala Thr Gly Met Cys Pro His Asp Ile Ala Thr Thr Leu Gln His
    930                 935                 940                 
Leu His Met Ile Asp Lys Arg Asp Gly Arg Phe Val Ile Ile Arg Arg
945                 950                 955                 960 
Glu Lys Leu Ile Leu Ser His Met Glu Lys Leu Lys Thr Cys Ser Arg
                965                 970                 975     
Ala Asn Glu Leu Asp Pro Asp Ser Leu Arg Trp Thr Pro Ile Leu Ile
            980                 985                 990         
Ser Asn Ala Ala Val Ser Glu Glu Glu Arg Glu Ala Glu Lys Glu Ala
        995                 1000                1005            
Glu Arg Leu Met Glu Gln Ala Ser Cys Trp Glu Lys Glu Glu Gln Glu
    1010                1015                1020                
Ile Leu Ser Thr Arg Ala Asn Ser Arg Gln Ser Pro Ala Lys Val Gln
1025                1030                1035                1040
Ser Lys Asn Lys Tyr Leu His Ser Pro Glu Ser Arg Pro Val Thr Gly
                1045                1050                1055    
Glu Arg Gly Gln Leu Leu Glu Leu Ser Lys Glu Ser Ser Glu Glu Glu
            1060                1065                1070        
Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
        1075                1080                1085            
Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    1090                1095                1100                
Asn Ile Gln Ser Ser Pro Pro Arg Leu Thr Lys Pro Gln Ser Val Ala
1105                1110                1115                1120
Ile Lys Arg Lys Arg Pro Phe Val Leu Lys Lys Lys Arg Gly Arg Lys
                1125                1130                1135    
Arg Arg Arg Ile Asn Ser Ser Val Thr Thr Glu Thr Ile Ser Glu Thr
            1140                1145                1150        
Thr Glu Val Leu Asn Glu Pro Phe Asp Asn Ser Asp Glu Glu Arg Pro
        1155                1160                1165            
Met Pro Gln Leu Glu Pro Thr Cys Glu Ile Glu Val Glu Glu Asp Gly
    1170                1175                1180                
Arg Lys Pro Val Leu Arg Lys Ala Phe Gln His Gln Pro Gly Lys Lys
1185                1190                1195                1200
Arg Gln Thr Glu Glu Glu Glu Gly Lys Asp Asn His Cys Phe Lys Asn
                1205                1210                1215    
Ala Asp Pro Cys Arg Asn Asn Met Asn Asp Asp Ser Ser Asn Leu Lys
            1220                1225                1230        
Glu Gly Ser Lys Asp Asn Pro Glu Pro Leu Lys Cys Lys Gln Val Trp
        1235                1240                1245            
Pro Lys Gly Thr Lys Arg Gly Leu Ser Lys Trp Arg Gln Asn Lys Glu
    1250                1255                1260                
Arg Lys Thr Gly Phe Lys Leu Asn Leu Tyr Thr Pro Pro Glu Thr Pro
1265                1270                1275                1280
Met Glu Pro Asp Glu Gln Val Thr Val Glu Glu Gln Lys Glu Thr Ser
                1285                1290                1295    
Glu Gly Lys Thr Ser Pro Ser Pro Ile Arg Ile Glu Glu Glu Val Lys
            1300                1305                1310        
Glu Thr Gly Glu Ala Leu Leu Pro Gln Glu Glu Asn Arg Arg Glu Glu
        1315                1320                1325            
Thr Cys Ala Pro Val Ser Pro Asn Thr Ser Pro Gly Glu Lys Pro Glu
    1330                1335                1340                
Asp Asp Leu Ile Lys Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
1345                1350                1355                1360
Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu Glu Gly Gly Gly
                1365                1370                1375    
Asn Val Glu Lys Asp Pro Asp Gly Ala Lys Ser Gln Glu Lys Glu Glu
            1380                1385                1390        
Pro Glu Ile Ser Thr Glu Lys Glu Asp Ser Ala Arg Leu Asp Asp His
        1395                1400                1405            
Glu Glu Glu Glu Glu Glu Asp Glu Glu Pro Ser His Asn Glu Asp His
    1410                1415                1420                
Asp Ala Asp Asp Glu Asp Asp Ser His Met Glu Ser Ala Glu Val Glu
1425                1430                1435                1440
Lys Glu Glu Leu Pro Arg Glu Ser Phe Lys Glu Val Leu Glu Asn Gln
                1445                1450                1455    
Glu Thr Phe Leu Asp Leu Asn Val Gln Pro Gly His Ser Asn Pro Glu
            1460                1465                1470        
Val Leu Met Asp Cys Gly Val Asp Leu Thr Ala Ser Cys Asn Ser Glu
        1475                1480                1485            
Pro Lys Glu Leu Ala Gly Asp Pro Glu Ala Val Pro Glu Ser Asp Glu
    1490                1495                1500                
Glu Pro Pro Pro Gly Glu Gln Ala Gln Lys Gln Asp Gln Lys Asn Ser
1505                1510                1515                1520
Lys Glu Val Asp Thr Glu Phe Lys Glu Gly Asn Pro Ala Thr Met Glu
                1525                1530                1535    
Ile Asp Ser Glu Thr Val Gln Ala Val Gln Ser Leu Thr Gln Glu Ser
            1540                1545                1550        
Ser Glu Gln Asp Asp Thr Phe Gln Asp Cys Ala Glu Thr Gln Glu Ala
        1555                1560                1565            
Cys Arg Ser Leu Gln Asn Tyr Thr Arg Ala Asp Gln Ser Pro Gln Ile
    1570                1575                1580                
Ala Thr Thr Leu Asp Asp Cys Gln Gln Ser Asp His Ser Ser Pro Val
1585                1590                1595                1600
Ser Ser Val His Ser His Pro Gly Gln Ser Val Arg Ser Val Asn Ser
                1605                1610                1615    
Pro Ser Val Pro Ala Leu Glu Asn Ser Tyr Ala Gln Ile Ser Pro Asp
            1620                1625                1630        
Gln Ser Ala Ile Ser Val Pro Ser Leu Gln Asn Met Glu Thr Ser Pro
        1635                1640                1645            
Met Met Asp Val Pro Ser Val Ser Asp His Ser Gln Gln Val Val Asp
    1650                1655                1660                
Ser Gly Phe Ser Asp Leu Gly Ser Ile Glu Ser Thr Thr Glu Asn Tyr
1665                1670                1675                1680
Glu Asn Pro Ser Ser Tyr Asp Ser Thr Met Gly Gly Ser Ile Cys Gly
                1685                1690                1695    
Asn Gly Ser Ser Gln Asn Ser Cys Ser Tyr Ser Asn Leu Thr Ser Ser
            1700                1705                1710        
Ser Leu Thr Gln Ser Ser Cys Ala Val Thr Gln Gln Met Ser Asn Ile
        1715                1720                1725            
Ser Gly Ser Cys Ser Met Leu Gln Gln Thr Ser Ile Ser Ser Pro Pro
    1730                1735                1740                
Thr Cys Ser Val Lys Ser Pro Gln Gly Cys Val Val Glu Arg Pro Pro
1745                1750                1755                1760
Ser Ser Ser Gln Gln Leu Ala Gln Cys Ser Met Ala Ala Asn Phe Thr
                1765                1770                1775    
Pro Pro Met Gln Leu Ala Glu Ile Pro Glu Thr Ser Asn Ala Asn Ile
            1780                1785                1790        
Gly Leu Tyr Glu Arg Met Gly Gln Ser Asp Phe Gly Ala Gly His Tyr
        1795                1800                1805            
Pro Gln Pro Ser Ala Thr Phe Ser Leu Ala Lys Leu Gln Gln Leu Thr
    1810                1815                1820                
Asn Thr Leu Ile Asp His Ser Leu Pro Tyr Ser His Ser Ala Ala Val
1825                1830                1835                1840
Thr Ser Tyr Ala Asn Ser Ala Ser Leu Ser Thr Pro Leu Ser Asn Thr
                1845                1850                1855    
Gly Leu Val Gln Leu Ser Gln Ser Pro His Ser Val Pro Gly Gly Pro
            1860                1865                1870        
Gln Ala Gln Ala Thr Met Thr Pro Pro Pro Asn Leu Thr Pro Pro Pro
        1875                1880                1885            
Met Asn Leu Pro Pro Pro Leu Leu Gln Arg Asn Met Ala Ala Ser Asn
    1890                1895                1900                
Ile Gly Ile Ser His Ser Gln Arg Leu Gln Thr Gln Ile Ala Ser Lys
1905                1910                1915                1920
Gly His Ile Ser Met Arg Thr Lys Ser Ala Ser Leu Ser Pro Ala Ala
                1925                1930                1935    
Ala Thr His Gln Ser Gln Ile Tyr Gly Arg Ser Gln Thr Val Ala Met
            1940                1945                1950        
Gln Gly Pro Ala Arg Thr Leu Thr Met Gln Arg Gly Met Asn Met Ser
        1955                1960                1965            
Val Asn Leu Met Pro Ala Pro Ala Tyr Asn Val Asn Ser Val Asn Met
    1970                1975                1980                
Asn Met Asn Thr Leu Asn Ala Met Asn Gly Tyr Ser Met Ser Gln Pro
1985                1990                1995                2000
Met Met Asn Ser Gly Tyr His Ser Asn His Gly Tyr Met Asn Gln Thr
                2005                2010                2015    
Pro Gln Tyr Pro Met Gln Met Gln Met Gly Met Met Gly Thr Gln Pro
            2020                2025                2030        
Tyr Ala Gln Gln Pro Met Gln Thr Pro Pro His Gly Asn Met Met Tyr
        2035                2040                2045            
Thr Ala Pro Gly His His Gly Tyr Met Asn Thr Gly Met Ser Lys Gln
    2050                2055                2060                
Ser Leu Asn Gly Ser Tyr Met Arg Arg
2065                2070            


<210> 7011
<211> 1781
<212> PRT
<213> Homo sapiens

<400> 7011
Met Val Lys Leu Ala Asn Pro Leu Tyr Thr Glu Trp Ile Leu Glu Ala
 1               5                  10                  15      
Ile Gln Lys Ile Lys Lys Gln Lys Gln Arg Pro Ser Glu Glu Arg Ile
            20                  25                  30          
Cys His Ala Val Ser Thr Ser His Gly Leu Asp Lys Lys Thr Val Ser
        35                  40                  45              
Glu Gln Leu Glu Leu Ser Val Gln Asp Gly Ser Val Leu Lys Val Thr
    50                  55                  60                  
Asn Lys Gly Leu Ala Ser Tyr Lys Asp Pro Asp Asn Pro Gly Arg Phe
65                  70                  75                  80  
Ser Ser Val Lys Pro Gly Thr Phe Pro Lys Ser Ala Lys Gly Ser Arg
                85                  90                  95      
Gly Ser Cys Asn Asp Leu Arg Asn Val Asp Trp Asn Lys Leu Leu Arg
            100                 105                 110         
Arg Ala Ile Glu Gly Leu Glu Glu Pro Asn Gly Ser Ser Leu Lys Asn
        115                 120                 125             
Ile Glu Lys Tyr Leu Arg Ser Gln Ser Asp Leu Thr Ser Thr Thr Asn
    130                 135                 140                 
Asn Pro Ala Phe Gln Gln Arg Leu Arg Leu Gly Ala Lys Arg Ala Val
145                 150                 155                 160 
Asn Asn Gly Arg Leu Leu Lys Asp Gly Pro Gln Tyr Arg Val Asn Tyr
                165                 170                 175     
Gly Ser Leu Asp Gly Lys Gly Ala Pro Gln Tyr Pro Ser Ala Phe Pro
            180                 185                 190         
Ser Ser Leu Pro Pro Val Ser Leu Leu Pro His Glu Lys Asp Gln Pro
        195                 200                 205             
Arg Ala Asp Pro Ile Pro Ile Cys Ser Phe Cys Leu Gly Thr Lys Glu
    210                 215                 220                 
Ser Asn Arg Glu Lys Lys Pro Glu Glu Leu Leu Ser Cys Ala Asp Cys
225                 230                 235                 240 
Gly Ser Ser Gly His Pro Ser Cys Leu Lys Phe Cys Pro Glu Leu Thr
                245                 250                 255     
Thr Asn Val Lys Ala Leu Arg Trp Gln Cys Ile Glu Cys Lys Thr Cys
            260                 265                 270         
Ser Ala Cys Arg Val Gln Gly Arg Asn Ala Asp Asn Met Leu Phe Cys
        275                 280                 285             
Asp Ser Cys Asp Arg Gly Phe His Met Glu Cys Cys Asp Pro Pro Leu
    290                 295                 300                 
Ser Arg Met Pro Lys Gly Met Trp Ile Cys Gln Val Cys Arg Pro Lys
305                 310                 315                 320 
Lys Lys Gly Arg Lys Leu Leu His Glu Lys Ala Ala Gln Ile Lys Arg
                325                 330                 335     
Arg Tyr Ala Lys Pro Ile Gly Arg Pro Lys Asn Lys Leu Lys Gln Arg
            340                 345                 350         
Leu Leu Ser Val Thr Ser Asp Glu Gly Ser Met Asn Ala Phe Thr Gly
        355                 360                 365             
Arg Gly Ser Pro Asp Thr Glu Ile Lys Ile Asn Ile Lys Gln Glu Ser
    370                 375                 380                 
Ala Asp Val Asn Val Ile Gly Asn Lys Asp Val Val Thr Glu Glu Asp
385                 390                 395                 400 
Leu Asp Val Phe Lys Gln Ala Gln Glu Leu Ser Trp Glu Lys Ile Glu
                405                 410                 415     
Cys Glu Ser Gly Val Glu Asp Cys Gly Arg Tyr Pro Ser Val Ile Glu
            420                 425                 430         
Phe Gly Lys Tyr Glu Ile Gln Thr Trp Tyr Ser Ser Pro Tyr Pro Gln
        435                 440                 445             
Glu Tyr Ala Arg Leu Pro Lys Leu Tyr Leu Cys Glu Phe Cys Leu Lys
    450                 455                 460                 
Tyr Met Lys Ser Lys Asn Ile Leu Leu Arg His Ser Lys Lys Cys Gly
465                 470                 475                 480 
Trp Phe His Pro Pro Ala Asn Glu Ile Tyr Arg Arg Lys Asp Leu Ser
                485                 490                 495     
Val Phe Glu Val Asp Gly Asn Met Ser Lys Ile Tyr Cys Gln Asn Leu
            500                 505                 510         
Cys Leu Leu Ala Lys Leu Phe Leu Asp His Lys Thr Leu Tyr Tyr Asp
        515                 520                 525             
Val Glu Pro Phe Leu Phe Tyr Val Leu Thr Lys Asn Asp Glu Lys Gly
    530                 535                 540                 
Cys His Leu Val Gly Tyr Leu Ser Lys Glu Lys Leu Cys Gln Gln Lys
545                 550                 555                 560 
Tyr Asn Val Ser Cys Ile Met Ile Met Pro Gln His Gln Arg Gln Gly
                565                 570                 575     
Phe Gly Arg Phe Leu Ile Asp Phe Ser Tyr Leu Leu Ser Arg Arg Glu
            580                 585                 590         
Gly Gln Ala Gly Ser Pro Glu Lys Pro Leu Ser Asp Leu Gly Arg Leu
        595                 600                 605             
Ser Tyr Leu Ala Tyr Trp Lys Ser Val Ile Leu Glu Tyr Leu Tyr His
    610                 615                 620                 
His His Glu Arg His Ile Ser Ile Lys Ala Ile Ser Arg Ala Thr Gly
625                 630                 635                 640 
Met Cys Pro His Asp Ile Ala Thr Thr Leu Gln His Leu His Met Ile
                645                 650                 655     
Asp Lys Arg Asp Gly Arg Phe Val Ile Ile Arg Arg Glu Lys Leu Ile
            660                 665                 670         
Leu Ser His Met Glu Lys Leu Lys Thr Cys Ser Arg Ala Asn Glu Leu
        675                 680                 685             
Asp Pro Asp Ser Leu Arg Trp Thr Pro Ile Leu Ile Ser Asn Ala Ala
    690                 695                 700                 
Val Ser Glu Glu Glu Arg Glu Ala Glu Lys Glu Ala Glu Arg Leu Met
705                 710                 715                 720 
Glu Gln Ala Ser Cys Trp Glu Lys Glu Glu Gln Glu Ile Leu Ser Thr
                725                 730                 735     
Arg Ala Asn Ser Arg Gln Ser Pro Ala Lys Val Gln Ser Lys Asn Lys
            740                 745                 750         
Tyr Leu His Ser Pro Glu Ser Arg Pro Val Thr Gly Glu Arg Gly Gln
        755                 760                 765             
Leu Leu Glu Leu Ser Lys Glu Ser Ser Glu Glu Glu Glu Glu Glu Glu
    770                 775                 780                 
Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu
785                 790                 795                 800 
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asn Ile Gln Ser
                805                 810                 815     
Ser Pro Pro Arg Leu Thr Lys Pro Gln Ser Val Ala Ile Lys Arg Lys
            820                 825                 830         
Arg Pro Phe Val Leu Lys Lys Lys Arg Gly Arg Lys Arg Arg Arg Ile
        835                 840                 845             
Asn Ser Ser Val Thr Thr Glu Thr Ile Ser Glu Thr Thr Glu Val Leu
    850                 855                 860                 
Asn Glu Pro Phe Asp Asn Ser Asp Glu Glu Arg Pro Met Pro Gln Leu
865                 870                 875                 880 
Glu Pro Thr Cys Glu Ile Glu Val Glu Glu Asp Gly Arg Lys Pro Val
                885                 890                 895     
Leu Arg Lys Ala Phe Gln His Gln Pro Gly Lys Lys Arg Gln Thr Glu
            900                 905                 910         
Glu Glu Glu Gly Lys Asp Asn His Cys Phe Lys Asn Ala Asp Pro Cys
        915                 920                 925             
Arg Asn Asn Met Asn Asp Asp Ser Ser Asn Leu Lys Glu Gly Ser Lys
    930                 935                 940                 
Asp Asn Pro Glu Pro Leu Lys Cys Lys Gln Val Trp Pro Lys Gly Thr
945                 950                 955                 960 
Lys Arg Gly Leu Ser Lys Trp Arg Gln Asn Lys Glu Arg Lys Thr Gly
                965                 970                 975     
Phe Lys Leu Asn Leu Tyr Thr Pro Pro Glu Thr Pro Met Glu Pro Asp
            980                 985                 990         
Glu Gln Val Thr Val Glu Glu Gln Lys Glu Thr Ser Glu Gly Lys Thr
        995                 1000                1005            
Ser Pro Ser Pro Ile Arg Ile Glu Glu Glu Val Lys Glu Thr Gly Glu
    1010                1015                1020                
Ala Leu Leu Pro Gln Glu Glu Asn Arg Arg Glu Glu Thr Cys Ala Pro
1025                1030                1035                1040
Val Ser Pro Asn Thr Ser Pro Gly Glu Lys Pro Glu Asp Asp Leu Ile
                1045                1050                1055    
Lys Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            1060                1065                1070        
Glu Glu Glu Glu Gly Glu Glu Glu Glu Gly Gly Gly Asn Val Glu Lys
        1075                1080                1085            
Asp Pro Asp Gly Ala Lys Ser Gln Glu Lys Glu Glu Pro Glu Ile Ser
    1090                1095                1100                
Thr Glu Lys Glu Asp Ser Ala Arg Leu Asp Asp His Glu Glu Glu Glu
1105                1110                1115                1120
Glu Glu Asp Glu Glu Pro Ser His Asn Glu Asp His Asp Ala Asp Asp
                1125                1130                1135    
Glu Asp Asp Ser His Met Glu Ser Ala Glu Val Glu Lys Glu Glu Leu
            1140                1145                1150        
Pro Arg Glu Ser Phe Lys Glu Val Leu Glu Asn Gln Glu Thr Phe Leu
        1155                1160                1165            
Asp Leu Asn Val Gln Pro Gly His Ser Asn Pro Glu Val Leu Met Asp
    1170                1175                1180                
Cys Gly Val Asp Leu Thr Ala Ser Cys Asn Ser Glu Pro Lys Glu Leu
1185                1190                1195                1200
Ala Gly Asp Pro Glu Ala Val Pro Glu Ser Asp Glu Glu Pro Pro Pro
                1205                1210                1215    
Gly Glu Gln Ala Gln Lys Gln Asp Gln Lys Asn Ser Lys Glu Val Asp
            1220                1225                1230        
Thr Glu Phe Lys Glu Gly Asn Pro Ala Thr Met Glu Ile Asp Ser Glu
        1235                1240                1245            
Thr Val Gln Ala Val Gln Ser Leu Thr Gln Glu Ser Ser Glu Gln Asp
    1250                1255                1260                
Asp Thr Phe Gln Asp Cys Ala Glu Thr Gln Glu Ala Cys Arg Ser Leu
1265                1270                1275                1280
Gln Asn Tyr Thr Arg Ala Asp Gln Ser Pro Gln Ile Ala Thr Thr Leu
                1285                1290                1295    
Asp Asp Cys Gln Gln Ser Asp His Ser Ser Pro Val Ser Ser Val His
            1300                1305                1310        
Ser His Pro Gly Gln Ser Val Arg Ser Val Asn Ser Pro Ser Val Pro
        1315                1320                1325            
Ala Leu Glu Asn Ser Tyr Ala Gln Ile Ser Pro Asp Gln Ser Ala Ile
    1330                1335                1340                
Ser Val Pro Ser Leu Gln Asn Met Glu Thr Ser Pro Met Met Asp Val
1345                1350                1355                1360
Pro Ser Val Ser Asp His Ser Gln Gln Val Val Asp Ser Gly Phe Ser
                1365                1370                1375    
Asp Leu Gly Ser Ile Glu Ser Thr Thr Glu Asn Tyr Glu Asn Pro Ser
            1380                1385                1390        
Ser Tyr Asp Ser Thr Met Gly Gly Ser Ile Cys Gly Asn Gly Ser Ser
        1395                1400                1405            
Gln Asn Ser Cys Ser Tyr Ser Asn Leu Thr Ser Ser Ser Leu Thr Gln
    1410                1415                1420                
Ser Ser Cys Ala Val Thr Gln Gln Met Ser Asn Ile Ser Gly Ser Cys
1425                1430                1435                1440
Ser Met Leu Gln Gln Thr Ser Ile Ser Ser Pro Pro Thr Cys Ser Val
                1445                1450                1455    
Lys Ser Pro Gln Gly Cys Val Val Glu Arg Pro Pro Ser Ser Ser Gln
            1460                1465                1470        
Gln Leu Ala Gln Cys Ser Met Ala Ala Asn Phe Thr Pro Pro Met Gln
        1475                1480                1485            
Leu Ala Glu Ile Pro Glu Thr Ser Asn Ala Asn Ile Gly Leu Tyr Glu
    1490                1495                1500                
Arg Met Gly Gln Ser Asp Phe Gly Ala Gly His Tyr Pro Gln Pro Ser
1505                1510                1515                1520
Ala Thr Phe Ser Leu Ala Lys Leu Gln Gln Leu Thr Asn Thr Leu Ile
                1525                1530                1535    
Asp His Ser Leu Pro Tyr Ser His Ser Ala Ala Val Thr Ser Tyr Ala
            1540                1545                1550        
Asn Ser Ala Ser Leu Ser Thr Pro Leu Ser Asn Thr Gly Leu Val Gln
        1555                1560                1565            
Leu Ser Gln Ser Pro His Ser Val Pro Gly Gly Pro Gln Ala Gln Ala
    1570                1575                1580                
Thr Met Thr Pro Pro Pro Asn Leu Thr Pro Pro Pro Met Asn Leu Pro
1585                1590                1595                1600
Pro Pro Leu Leu Gln Arg Asn Met Ala Ala Ser Asn Ile Gly Ile Ser
                1605                1610                1615    
His Ser Gln Arg Leu Gln Thr Gln Ile Ala Ser Lys Gly His Ile Ser
            1620                1625                1630        
Met Arg Thr Lys Ser Ala Ser Leu Ser Pro Ala Ala Ala Thr His Gln
        1635                1640                1645            
Ser Gln Ile Tyr Gly Arg Ser Gln Thr Val Ala Met Gln Gly Pro Ala
    1650                1655                1660                
Arg Thr Leu Thr Met Gln Arg Gly Met Asn Met Ser Val Asn Leu Met
1665                1670                1675                1680
Pro Ala Pro Ala Tyr Asn Val Asn Ser Val Asn Met Asn Met Asn Thr
                1685                1690                1695    
Leu Asn Ala Met Asn Gly Tyr Ser Met Ser Gln Pro Met Met Asn Ser
            1700                1705                1710        
Gly Tyr His Ser Asn His Gly Tyr Met Asn Gln Thr Pro Gln Tyr Pro
        1715                1720                1725            
Met Gln Met Gln Met Gly Met Met Gly Thr Gln Pro Tyr Ala Gln Gln
    1730                1735                1740                
Pro Met Gln Thr Pro Pro His Gly Asn Met Met Tyr Thr Ala Pro Gly
1745                1750                1755                1760
His His Gly Tyr Met Asn Thr Gly Met Ser Lys Gln Ser Leu Asn Gly
                1765                1770                1775    
Ser Tyr Met Arg Arg
            1780    


<210> 7012
<211> 2948
<212> PRT
<213> Homo sapiens

<400> 7012
Met Gly Asn Glu Asn Ser Thr Ser Asp Asn Gln Arg Thr Leu Ser Ala
 1               5                  10                  15      
Gln Thr Pro Arg Ser Ala Gln Pro Pro Gly Asn Ser Gln Asn Ile Lys
            20                  25                  30          
Arg Lys Gln Gln Asp Thr Pro Gly Ser Pro Asp His Arg Asp Ala Ser
        35                  40                  45              
Ser Ile Gly Ser Val Gly Leu Gly Gly Phe Cys Thr Ala Ser Glu Ser
    50                  55                  60                  
Ser Ala Ser Leu Asp Pro Cys Leu Val Ser Pro Glu Val Thr Glu Pro
65                  70                  75                  80  
Arg Lys Asp Pro Gln Gly Ala Arg Gly Pro Glu Gly Ser Leu Leu Pro
                85                  90                  95      
Ser Pro Pro Pro Ser Gln Glu Arg Glu His Pro Ser Ser Ser Met Pro
            100                 105                 110         
Phe Ala Glu Cys Pro Pro Glu Gly Cys Leu Ala Ser Pro Ala Ala Ala
        115                 120                 125             
Pro Glu Asp Gly Pro Gln Thr Gln Ser Pro Arg Arg Glu Pro Ala Pro
    130                 135                 140                 
Asn Ala Pro Gly Asp Ile Ala Ala Ala Phe Pro Ala Glu Arg Asp Ser
145                 150                 155                 160 
Ser Thr Pro Tyr Gln Glu Ile Ala Ala Val Pro Ser Ala Gly Arg Glu
                165                 170                 175     
Arg Gln Pro Lys Glu Glu Gly Gln Lys Ser Ser Phe Ser Phe Ser Ser
            180                 185                 190         
Gly Ile Asp Gln Ser Pro Gly Met Ser Pro Val Pro Leu Arg Glu Pro
        195                 200                 205             
Met Lys Ala Pro Leu Cys Gly Glu Gly Asp Gln Pro Gly Gly Phe Glu
    210                 215                 220                 
Ser Gln Glu Lys Glu Ala Ala Gly Gly Phe Pro Pro Ala Glu Ser Arg
225                 230                 235                 240 
Gln Gly Val Ala Ser Val Gln Val Thr Pro Glu Ala Pro Ala Ala Ala
                245                 250                 255     
Gln Gln Gly Thr Glu Ser Ser Ala Val Leu Glu Lys Ser Pro Leu Lys
            260                 265                 270         
Pro Met Ala Pro Ile Pro Gln Asp Pro Ala Pro Arg Ala Ser Asp Arg
        275                 280                 285             
Glu Arg Gly Gln Gly Glu Ala Pro Pro Gln Tyr Leu Thr Asp Asp Leu
    290                 295                 300                 
Glu Phe Leu Arg Ala Cys His Leu Pro Arg Ser Asn Ser Gly Ala Ala
305                 310                 315                 320 
Pro Glu Ala Glu Val Asn Ala Ala Ser Gln Glu Ser Cys Gln Gln Pro
                325                 330                 335     
Val Gly Ala Tyr Leu Pro His Ala Glu Leu Pro Trp Gly Leu Pro Ser
            340                 345                 350         
Pro Ala Leu Val Pro Glu Ala Gly Gly Ser Gly Lys Glu Ala Leu Asp
        355                 360                 365             
Thr Ile Asp Val Gln Gly His Pro Gln Thr Gly Met Arg Gly Thr Lys
    370                 375                 380                 
Pro Asn Gln Val Val Cys Val Ala Ala Gly Gly Gln Pro Glu Gly Gly
385                 390                 395                 400 
Leu Pro Val Ser Pro Glu Pro Ser Leu Leu Thr Pro Thr Glu Glu Ala
                405                 410                 415     
His Pro Ala Ser Ser Leu Ala Ser Phe Pro Ala Ala Gln Ile Pro Ile
            420                 425                 430         
Ala Val Glu Glu Pro Gly Ser Ser Ser Arg Glu Ser Val Ser Lys Ala
        435                 440                 445             
Gly Met Pro Val Ser Ala Asp Ala Ala Lys Glu Val Val Asp Ala Gly
    450                 455                 460                 
Leu Val Gly Leu Glu Arg Gln Val Ser Asp Leu Gly Ser Lys Gly Glu
465                 470                 475                 480 
His Pro Glu Gly Asp Pro Gly Glu Val Pro Ala Pro Ser Pro Gln Glu
                485                 490                 495     
Arg Gly Glu His Leu Asn Thr Glu Gln Ser His Glu Val Gln Pro Gly
            500                 505                 510         
Val Pro Pro Pro Pro Leu Pro Lys Glu Gln Ser His Glu Val Gln Pro
        515                 520                 525             
Gly Ala Pro Pro Pro Pro Leu Pro Lys Ala Pro Ser Glu Ser Ala Arg
    530                 535                 540                 
Gly Pro Pro Gly Pro Thr Asp Gly Ala Lys Val His Glu Asp Ser Thr
545                 550                 555                 560 
Ser Pro Ala Val Ala Lys Glu Gly Ser Arg Ser Pro Gly Asp Ser Pro
                565                 570                 575     
Gly Gly Lys Glu Glu Ala Pro Glu Pro Pro Asp Gly Gly Asp Pro Gly
            580                 585                 590         
Asn Leu Gln Gly Glu Asp Ser Gln Ala Phe Ser Ser Lys Arg Asp Pro
        595                 600                 605             
Glu Val Gly Lys Asp Glu Leu Ser Lys Pro Ser Ser Asp Ala Glu Ser
    610                 615                 620                 
Arg Asp His Pro Ser Ser His Ser Ala Gln Pro Pro Arg Lys Gly Gly
625                 630                 635                 640 
Ala Gly His Thr Asp Gly Pro His Ser Gln Thr Ala Glu Ala Asp Ala
                645                 650                 655     
Ser Gly Leu Pro His Lys Leu Gly Glu Glu Asp Pro Val Leu Pro Pro
            660                 665                 670         
Val Pro Asp Gly Ala Gly Glu Pro Thr Val Pro Glu Gly Ala Ile Trp
        675                 680                 685             
Glu Gly Ser Gly Leu Gln Pro Lys Cys Pro Asp Thr Leu Gln Ser Arg
    690                 695                 700                 
Glu Gly Leu Gly Arg Met Glu Ser Phe Leu Thr Leu Glu Ser Glu Lys
705                 710                 715                 720 
Ser Asp Phe Pro Pro Thr Pro Val Ala Glu Val Ala Pro Lys Ala Gln
                725                 730                 735     
Glu Gly Glu Ser Thr Leu Glu Ile Arg Lys Met Gly Ser Cys Asp Gly
            740                 745                 750         
Glu Gly Leu Leu Thr Ser Pro Asp Gln Pro Arg Gly Pro Ala Cys Asp
        755                 760                 765             
Ala Ser Arg Gln Glu Phe His Ala Gly Val Pro His Pro Pro Gln Gly
    770                 775                 780                 
Glu Asn Leu Ala Ala Asp Leu Gly Leu Thr Ala Leu Ile Leu Asp Gln
785                 790                 795                 800 
Asp Gln Gln Gly Ile Pro Ser Cys Pro Gly Glu Gly Trp Ile Arg Gly
                805                 810                 815     
Ala Ala Ser Glu Trp Pro Leu Leu Ser Ser Glu Lys His Phe Gln Pro
            820                 825                 830         
Ser Gln Ala Gln Pro Glu Thr Ser Ile Phe Asp Val Leu Lys Glu Gln
        835                 840                 845             
Ala Gln Pro Pro Glu Asn Gly Lys Glu Thr Ser Pro Ser His Pro Gly
    850                 855                 860                 
Phe Lys Asp Gln Gly Ala Asp Ser Ser Gln Ile His Val Pro Val Glu
865                 870                 875                 880 
Pro Gln Glu Asp Asn Asn Leu Pro Thr His Gly Gly Gln Glu Gln Ala
                885                 890                 895     
Leu Gly Ser Glu Leu Gln Ser Gln Leu Pro Lys Gly Thr Leu Ser Asp
            900                 905                 910         
Thr Pro Thr Ser Ser Pro Thr Asp Met Val Trp Glu Ser Ser Leu Thr
        915                 920                 925             
Glu Glu Ser Glu Leu Ser Ala Pro Thr Arg Gln Lys Leu Pro Ala Leu
    930                 935                 940                 
Gly Glu Lys Arg Pro Glu Gly Ala Cys Gly Asp Gly Gln Ser Ser Arg
945                 950                 955                 960 
Val Ser Pro Pro Ala Ala Asp Val Leu Lys Asp Phe Ser Leu Ala Gly
                965                 970                 975     
Asn Phe Ser Arg Lys Glu Thr Cys Cys Thr Gly Gln Gly Pro Asn Lys
            980                 985                 990         
Ser Gln Gln Ala Leu Ala Asp Ala Leu Glu Glu Gly Ser Gln His Glu
        995                 1000                1005            
Glu Ala Cys Gln Arg His Pro Gly Ala Ser Glu Ala Ala Asp Gly Cys
    1010                1015                1020                
Ser Pro Leu Trp Gly Leu Ser Lys Arg Glu Met Ala Ser Gly Asn Thr
1025                1030                1035                1040
Gly Glu Ala Pro Pro Cys Gln Pro Asp Ser Val Ala Leu Leu Asp Ala
                1045                1050                1055    
Val Pro Cys Leu Pro Ala Leu Ala Pro Ala Ser Pro Gly Val Thr Pro
            1060                1065                1070        
Thr Gln Asp Ala Pro Glu Thr Glu Ala Cys Asp Glu Thr Gln Glu Gly
        1075                1080                1085            
Arg Gln Gln Pro Val Pro Ala Pro Gln Gln Lys Met Glu Cys Arg Ala
    1090                1095                1100                
Thr Ser Asp Ala Glu Ser Pro Lys Leu Leu Ala Ser Phe Pro Ser Ala
1105                1110                1115                1120
Gly Glu Gln Gly Gly Glu Ala Gly Ala Ala Glu Thr Gly Gly Ser Ala
                1125                1130                1135    
Gly Ala Gly Asp Pro Gly Lys Gln Gln Ala Pro Glu Lys Pro Gly Glu
            1140                1145                1150        
Ala Thr Leu Ser Cys Gly Leu Leu Gln Thr Glu His Cys Leu Thr Ser
        1155                1160                1165            
Gly Glu Glu Ala Ser Thr Ser Ala Leu Arg Glu Ser Cys Gln Ala Glu
    1170                1175                1180                
His Pro Met Ala Ser Cys Gln Asp Ala Leu Leu Pro Ala Arg Glu Leu
1185                1190                1195                1200
Gly Gly Ile Pro Arg Ser Thr Met Asp Phe Ser Thr His Gln Ala Val
                1205                1210                1215    
Pro Asp Pro Lys Glu Leu Leu Leu Ser Gly Pro Pro Glu Val Ala Ala
            1220                1225                1230        
Pro Asp Thr Pro Tyr Leu His Val Asp Ser Ala Ala Gln Arg Gly Ala
        1235                1240                1245            
Glu Asp Ser Gly Val Lys Ala Val Ser Ser Ala Asp Pro Arg Ala Pro
    1250                1255                1260                
Gly Glu Ser Pro Cys Pro Val Gly Glu Pro Pro Leu Ala Leu Glu Asn
1265                1270                1275                1280
Ala Ala Ser Leu Lys Leu Phe Ala Gly Ser Leu Ala Pro Leu Leu Gln
                1285                1290                1295    
Pro Gly Ala Ala Gly Gly Glu Ile Pro Ala Val Gln Ala Ser Ser Gly
            1300                1305                1310        
Ser Pro Lys Ala Arg Thr Thr Glu Gly Pro Val Asp Ser Met Pro Cys
        1315                1320                1325            
Leu Asp Arg Met Pro Leu Leu Ala Lys Gly Lys Gln Ala Thr Gly Glu
    1330                1335                1340                
Glu Lys Ala Ala Thr Ala Pro Gly Ala Gly Ala Lys Ala Ser Gly Glu
1345                1350                1355                1360
Gly Met Ala Gly Asp Ala Ala Gly Glu Thr Glu Gly Ser Met Glu Arg
                1365                1370                1375    
Met Gly Glu Pro Ser Gln Asp Pro Lys Gln Gly Thr Ser Gly Gly Val
            1380                1385                1390        
Asp Thr Ser Ser Glu Gln Ile Ala Thr Leu Thr Gly Phe Pro Asp Phe
        1395                1400                1405            
Arg Glu His Ile Ala Lys Ile Phe Glu Lys Pro Val Leu Gly Ala Leu
    1410                1415                1420                
Ala Thr Pro Gly Glu Lys Ala Gly Ala Gly Arg Ser Ala Val Gly Lys
1425                1430                1435                1440
Asp Leu Thr Arg Pro Leu Gly Pro Glu Lys Leu Leu Asp Gly Pro Pro
                1445                1450                1455    
Gly Val Asp Val Thr Leu Leu Pro Ala Pro Pro Ala Arg Leu Gln Val
            1460                1465                1470        
Glu Lys Lys Gln Gln Leu Ala Gly Glu Ala Glu Ile Ser His Leu Ala
        1475                1480                1485            
Leu Gln Asp Pro Ala Ser Asp Lys Leu Leu Gly Pro Ala Gly Leu Thr
    1490                1495                1500                
Trp Glu Arg Asn Leu Pro Gly Ala Gly Val Gly Lys Glu Met Ala Gly
1505                1510                1515                1520
Val Pro Pro Thr Leu Arg Glu Asp Glu Arg Pro Glu Gly Pro Gly Ala
                1525                1530                1535    
Ala Trp Pro Gly Leu Glu Gly Gln Ala Tyr Ser Gln Leu Glu Arg Ser
            1540                1545                1550        
Arg Gln Glu Leu Ala Ser Gly Leu Pro Ser Pro Ala Ala Thr Gln Glu
        1555                1560                1565            
Leu Pro Val Glu Arg Ala Ala Ala Phe Gln Val Ala Pro His Ser His
    1570                1575                1580                
Gly Glu Glu Ala Val Ala Gln Asp Arg Ile Pro Ser Gly Lys Gln His
1585                1590                1595                1600
Gln Glu Thr Ser Ala Cys Asp Ser Pro His Gly Glu Asp Gly Pro Gly
                1605                1610                1615    
Asp Phe Ala His Thr Gly Val Pro Gly His Val Pro Arg Ser Thr Cys
            1620                1625                1630        
Ala Pro Ser Pro Gln Arg Glu Val Leu Thr Val Pro Glu Ala Asn Ser
        1635                1640                1645            
Glu Pro Trp Thr Leu Asp Thr Leu Gly Gly Glu Arg Arg Pro Gly Val
    1650                1655                1660                
Thr Ala Gly Ile Leu Glu Met Arg Asn Ala Leu Gly Asn Gln Ser Thr
1665                1670                1675                1680
Pro Ala Pro Pro Thr Gly Glu Val Ala Asp Thr Pro Leu Glu Pro Gly
                1685                1690                1695    
Lys Val Ala Gly Ala Ala Gly Glu Ala Glu Gly Asp Ile Thr Leu Ser
            1700                1705                1710        
Thr Ala Glu Thr Gln Ala Cys Ala Ser Gly Asp Leu Pro Glu Ala Gly
        1715                1720                1725            
Thr Thr Arg Thr Phe Ser Val Val Ala Gly Asp Leu Val Leu Pro Gly
    1730                1735                1740                
Ser Cys Gln Asp Pro Ala Cys Ser Asp Lys Ala Pro Gly Met Glu Gly
1745                1750                1755                1760
Thr Ala Ala Leu His Gly Asp Ser Pro Ala Arg Pro Gln Gln Ala Lys
                1765                1770                1775    
Glu Gln Pro Gly Pro Glu Arg Pro Ile Pro Ala Gly Asp Gly Lys Val
            1780                1785                1790        
Cys Val Ser Ser Pro Pro Glu Pro Asp Glu Thr His Asp Pro Lys Leu
        1795                1800                1805            
Gln His Leu Ala Pro Glu Glu Leu His Thr Asp Arg Glu Ser Pro Arg
    1810                1815                1820                
Pro Gly Pro Ser Met Leu Pro Ser Val Pro Lys Lys Asp Ala Pro Arg
1825                1830                1835                1840
Val Met Asp Lys Val Thr Ser Asp Glu Thr Arg Gly Ala Glu Gly Thr
                1845                1850                1855    
Glu Ser Ser Pro Val Ala Asp Asp Ile Ile Gln Pro Ala Ala Pro Ala
            1860                1865                1870        
Asp Leu Glu Ser Pro Thr Leu Ala Ala Ser Ser Tyr His Gly Asp Val
        1875                1880                1885            
Val Gly Gln Val Ser Thr Asp Leu Ile Ala Gln Ser Ile Ser Pro Ala
    1890                1895                1900                
Ala Ala His Ala Gly Leu Pro Pro Ser Ala Ala Glu His Ile Val Ser
1905                1910                1915                1920
Pro Ser Ala Pro Ala Gly Asp Arg Val Glu Ala Ser Thr Pro Ser Cys
                1925                1930                1935    
Pro Asp Pro Ala Lys Asp Leu Ser Arg Ser Ser Asp Ser Glu Glu Ala
            1940                1945                1950        
Phe Glu Thr Pro Glu Ser Thr Thr Pro Val Lys Ala Pro Pro Ala Pro
        1955                1960                1965            
Pro Pro Pro Pro Pro Glu Val Ile Pro Glu Pro Glu Val Ser Thr Gln
    1970                1975                1980                
Pro Pro Pro Glu Glu Pro Gly Cys Gly Ser Glu Thr Val Pro Val Pro
1985                1990                1995                2000
Asp Gly Pro Arg Ser Asp Ser Val Glu Gly Ser Pro Phe Arg Pro Pro
                2005                2010                2015    
Ser His Ser Phe Ser Ala Val Phe Asp Glu Asp Lys Pro Ile Ala Ser
            2020                2025                2030        
Ser Gly Thr Tyr Asn Leu Asp Phe Asp Asn Ile Glu Leu Val Asp Thr
        2035                2040                2045            
Phe Gln Thr Leu Glu Pro Arg Ala Ser Asp Ala Lys Asn Gln Glu Gly
    2050                2055                2060                
Lys Val Asn Thr Arg Arg Lys Ser Thr Asp Ser Val Pro Ile Ser Lys
2065                2070                2075                2080
Ser Thr Leu Ser Arg Ser Leu Ser Leu Gln Ala Ser Asp Phe Asp Gly
                2085                2090                2095    
Ala Ser Ser Ser Gly Asn Pro Glu Ala Val Ala Leu Ala Pro Asp Ala
            2100                2105                2110        
Tyr Ser Thr Gly Ser Ser Ser Ala Ser Ser Thr Leu Lys Arg Thr Lys
        2115                2120                2125            
Lys Pro Arg Pro Pro Ser Leu Lys Lys Lys Gln Thr Thr Lys Lys Pro
    2130                2135                2140                
Thr Glu Thr Pro Pro Val Lys Glu Thr Gln Gln Glu Pro Asp Glu Glu
2145                2150                2155                2160
Ser Leu Val Pro Ser Gly Glu Asn Leu Ala Ser Glu Thr Lys Thr Glu
                2165                2170                2175    
Ser Ala Lys Thr Glu Gly Pro Ser Pro Ala Leu Leu Glu Glu Thr Pro
            2180                2185                2190        
Leu Glu Pro Ala Val Gly Pro Lys Ala Ala Cys Pro Leu Asp Ser Glu
        2195                2200                2205            
Ser Ala Glu Gly Val Val Pro Pro Ala Ser Gly Gly Gly Arg Val Gln
    2210                2215                2220                
Asn Ser Pro Pro Val Gly Arg Lys Thr Leu Pro Leu Thr Thr Ala Pro
2225                2230                2235                2240
Glu Ala Gly Glu Val Thr Pro Ser Asp Ser Gly Gly Gln Glu Asp Ser
                2245                2250                2255    
Pro Ala Lys Gly Leu Ser Val Arg Leu Glu Phe Asp Tyr Ser Glu Asp
            2260                2265                2270        
Lys Ser Ser Trp Asp Asn Gln Gln Glu Asn Pro Pro Pro Thr Lys Lys
        2275                2280                2285            
Ile Gly Lys Lys Pro Val Ala Lys Met Pro Leu Arg Arg Pro Lys Met
    2290                2295                2300                
Lys Lys Thr Pro Glu Lys Leu Asp Asn Thr Pro Ala Ser Pro Pro Arg
2305                2310                2315                2320
Ser Pro Ala Glu Pro Asn Asp Ile Pro Ile Ala Lys Gly Thr Tyr Thr
                2325                2330                2335    
Phe Asp Ile Asp Lys Trp Asp Asp Pro Asn Phe Asn Pro Phe Ser Ser
            2340                2345                2350        
Thr Ser Lys Met Gln Glu Ser Pro Lys Leu Pro Gln Gln Ser Tyr Asn
        2355                2360                2365            
Phe Asp Pro Asp Thr Cys Asp Glu Ser Val Asp Pro Phe Lys Thr Ser
    2370                2375                2380                
Ser Lys Thr Pro Ser Ser Pro Ser Lys Ser Pro Ala Ser Phe Glu Ile
2385                2390                2395                2400
Pro Ala Ser Ala Met Glu Ala Asn Gly Val Asp Gly Asp Gly Leu Asn
                2405                2410                2415    
Lys Pro Ala Lys Lys Lys Lys Thr Pro Leu Lys Thr Asp Thr Phe Arg
            2420                2425                2430        
Val Lys Lys Ser Pro Lys Arg Ser Pro Leu Ser Asp Pro Pro Ser Gln
        2435                2440                2445            
Asp Pro Thr Pro Ala Ala Thr Pro Glu Thr Pro Pro Val Ile Ser Ala
    2450                2455                2460                
Val Val His Ala Thr Asp Glu Glu Lys Leu Ala Val Thr Asn Gln Lys
2465                2470                2475                2480
Trp Thr Cys Met Thr Val Asp Leu Glu Ala Asp Lys Gln Asp Tyr Pro
                2485                2490                2495    
Gln Pro Ser Asp Leu Ser Thr Phe Val Asn Glu Thr Lys Phe Ser Ser
            2500                2505                2510        
Pro Thr Glu Glu Leu Asp Tyr Arg Asn Ser Tyr Glu Ile Glu Tyr Met
        2515                2520                2525            
Glu Lys Ile Gly Ser Ser Leu Pro Gln Asp Asp Asp Ala Pro Lys Lys
    2530                2535                2540                
Gln Ala Leu Tyr Leu Met Phe Asp Thr Ser Gln Glu Ser Pro Val Lys
2545                2550                2555                2560
Ser Ser Pro Val Arg Met Ser Glu Ser Pro Thr Pro Cys Ser Gly Ser
                2565                2570                2575    
Ser Phe Glu Glu Thr Glu Ala Leu Val Asn Thr Ala Ala Lys Asn Gln
            2580                2585                2590        
His Pro Val Pro Arg Gly Leu Ala Pro Asn Gln Glu Ser His Leu Gln
        2595                2600                2605            
Val Pro Glu Lys Ser Ser Gln Lys Glu Leu Glu Ala Met Gly Leu Gly
    2610                2615                2620                
Thr Pro Ser Glu Ala Ile Glu Ile Thr Ala Pro Glu Gly Ser Phe Ala
2625                2630                2635                2640
Ser Ala Asp Ala Leu Leu Ser Arg Leu Ala His Pro Val Ser Leu Cys
                2645                2650                2655    
Gly Ala Leu Asp Tyr Leu Glu Pro Asp Leu Ala Glu Lys Asn Pro Pro
            2660                2665                2670        
Leu Phe Ala Gln Lys Leu Gln Glu Glu Leu Glu Phe Ala Ile Met Arg
        2675                2680                2685            
Ile Glu Ala Leu Lys Leu Ala Arg Gln Ile Ala Leu Ala Ser Arg Ser
    2690                2695                2700                
His Gln Asp Ala Lys Arg Glu Ala Ala His Pro Thr Asp Val Ser Ile
2705                2710                2715                2720
Ser Lys Thr Ala Leu Tyr Ser Arg Ile Gly Thr Ala Glu Val Glu Lys
                2725                2730                2735    
Pro Ala Gly Leu Leu Phe Gln Gln Pro Asp Leu Asp Ser Ala Leu Gln
            2740                2745                2750        
Ile Ala Arg Ala Glu Ile Ile Thr Lys Glu Arg Glu Val Ser Glu Trp
        2755                2760                2765            
Lys Asp Lys Tyr Glu Glu Ser Arg Arg Glu Val Met Glu Met Arg Lys
    2770                2775                2780                
Ile Val Ala Glu Tyr Glu Lys Thr Ile Ala Gln Met Ile Glu Asp Glu
2785                2790                2795                2800
Gln Arg Glu Lys Ser Val Ser His Gln Thr Val Gln Gln Leu Val Leu
                2805                2810                2815    
Glu Lys Glu Gln Ala Leu Ala Asp Leu Asn Ser Val Glu Lys Ser Leu
            2820                2825                2830        
Ala Asp Leu Phe Arg Arg Tyr Glu Lys Met Lys Glu Val Leu Glu Gly
        2835                2840                2845            
Phe Arg Lys Asn Glu Glu Val Leu Lys Arg Cys Ala Gln Glu Tyr Leu
    2850                2855                2860                
Ser Arg Val Lys Lys Glu Glu Gln Arg Tyr Gln Ala Leu Lys Val His
2865                2870                2875                2880
Ala Glu Glu Lys Leu Asp Arg Ala Asn Ala Glu Ile Ala Gln Val Gln
                2885                2890                2895    
Gly Lys Ala Lys Gln Glu Gln Ala Ala His Gln Ala Ser Leu Arg Lys
            2900                2905                2910        
Glu Gln Leu Arg Val Asp Ala Leu Glu Arg Thr Leu Glu Gln Lys Asn
        2915                2920                2925            
Lys Glu Ile Glu Glu Leu Thr Lys Ile Cys Asp Glu Leu Ile Ala Lys
    2930                2935                2940                
Met Gly Lys Ser
2945            


<210> 7013
<211> 441
<212> PRT
<213> Homo sapiens

<400> 7013
Lys Met Phe Thr Leu Leu Asp Val Val Asn Cys Lys Ala Arg Phe Ile
 1               5                  10                  15      
His Asp Gly Pro Glu Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser
            20                  25                  30          
Val Met Ala Trp Leu Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr
        35                  40                  45              
Asp Leu Leu Pro Ile Gln Val Asn Pro Val Asn Asp Pro Pro His Ile
    50                  55                  60                  
Ile Phe Pro His Gly Ser Leu Met Val Ile Leu Glu His Thr Gln Lys
65                  70                  75                  80  
Pro Leu Gly Pro Glu Val Leu Gln Ala Tyr Asp Leu Asp Ser Ala Cys
                85                  90                  95      
Glu Gly Leu Thr Phe Gln Leu Leu Gly Thr Pro Ser Gly Leu Pro Val
            100                 105                 110         
Glu His Arg Asp Gln Pro Gly Glu Pro Val Thr Glu Phe Ser Cys Trp
        115                 120                 125             
Glu Leu Glu Ala Gly Ser Leu Val Tyr Val His Cys Gly Gly Pro Thr
    130                 135                 140                 
Gln Asp Leu Thr Phe Arg Val Ser Asn Gly Leu Gln Ala Ser Pro Pro
145                 150                 155                 160 
Ala Met Leu Lys Val Val Ala Val Gln Leu Ala Ile Gln Ile His Arg
                165                 170                 175     
Ser Thr Gly Leu His Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro
            180                 185                 190         
Thr Asn Leu Leu Val Glu Thr Ser Ala Val Gly Gln Asp Val Thr Val
        195                 200                 205             
Leu Phe Arg Val Thr Gly Gly Leu Pro Phe Arg Glu Leu Gln Lys Gln
    210                 215                 220                 
Gly Ala Gly Gly Val Glu Asp Ala Glu Trp Trp Val Thr Gln Ala Phe
225                 230                 235                 240 
His Gln Gln Asp Val Glu Gln Gly His Val Arg Tyr Leu Ser Thr Asp
                245                 250                 255     
Pro Gln His Tyr Thr Glu Asp Thr Val Glu Asn Leu Asp Leu Gln Val
            260                 265                 270         
Gln Val Ser Trp Glu Ile Leu Ser Asn Leu Ser Phe Leu Val Thr Ile
        275                 280                 285             
Gln Arg Ala Thr Val Trp Met Leu Gln Leu Glu Pro Leu His Thr Gln
    290                 295                 300                 
Asn Thr Gln Gln Glu Ala Leu Thr Thr Ala His Leu Glu Ala Thr Leu
305                 310                 315                 320 
Glu Glu Ala Gly Pro Ser Pro Pro Thr Phe His Cys Glu Val Val Gln
                325                 330                 335     
Ala Pro Arg Lys Gly Asn Phe Gln Leu Gln Gly Thr Met Leu Ser Asp
            340                 345                 350         
Gly Gln Gly Phe Thr Gln Asp Asp Val Gln Ala Ala Glu Val Thr Tyr
        355                 360                 365             
Gly Ala Met Ala His Ala Ser Val Ala Val Glu Asp Thr Phe Cys Phe
    370                 375                 380                 
His Val Thr Ala Pro Pro Tyr Phe Ser Pro Leu Cys Thr Phe Ser Ile
385                 390                 395                 400 
His Ile Gly Gly Asp Pro Asp Met Pro Val Leu Val Val Pro Glu Gly
                405                 410                 415     
Gly Gly Cys Val Leu Ser Ala Asp Gln Leu Phe Ile Lys Ser Leu Asn
            420                 425                 430         
Ser Ala Arg Tyr Leu Tyr Glu Val Met
        435                 440     


<210> 7014
<211> 445
<212> PRT
<213> Homo sapiens

<400> 7014
Lys Met Phe Thr Leu Leu Asp Val Val Asn Cys Lys Ala Arg Phe Ile
 1               5                  10                  15      
His Asp Gly Pro Glu Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser
            20                  25                  30          
Val Met Ala Trp Leu Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr
        35                  40                  45              
Asp Leu Leu Pro Ile Gln Val Asn Pro Val Asn Asp Pro Pro His Ile
    50                  55                  60                  
Ile Phe Pro His Gly Ser Leu Met Val Ile Leu Glu His Thr Gln Lys
65                  70                  75                  80  
Pro Leu Gly Pro Glu Val Leu Gln Ala Tyr Asp Leu Asp Ser Ala Cys
                85                  90                  95      
Glu Gly Leu Ala Phe Gln Leu Leu Gly Thr Pro Ser Gly Leu Pro Val
            100                 105                 110         
Asp His Arg Asp Gln Pro Gly Glu Pro Val Thr Glu Phe Ser Cys Trp
        115                 120                 125             
Glu Leu Glu Ala Gly Ser Leu Val Tyr Val His Cys Gly Gly Pro Thr
    130                 135                 140                 
Gln Asp Leu Thr Phe Arg Val Ser Asn Gly Leu Gln Ala Ser Pro Pro
145                 150                 155                 160 
Ala Met Leu Lys Val Val Ala Val Gln Leu Ala Ile Gln Ile His Arg
                165                 170                 175     
Ser Thr Gly Leu His Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro
            180                 185                 190         
Thr Asn Leu Leu Val Glu Thr Ser Ala Val Gly Gln Asp Val Thr Val
        195                 200                 205             
Leu Phe His Val Thr Gly Gly Leu Pro Phe Arg Glu Leu Gln Lys Gln
    210                 215                 220                 
Gly Ala Gly Gly Val Glu Asp Ala Glu Trp Trp Val Thr Gln Ala Phe
225                 230                 235                 240 
His Gln Gln Asp Val Glu Gln Gly His Val Arg Tyr Arg Ser Thr Asp
                245                 250                 255     
Pro Gln His Tyr Thr Glu Asp Thr Val Glu Asn Leu Asp Leu Gln Val
            260                 265                 270         
Gln Val Ser Trp Glu Ile Leu Ser Asn Leu Ser Phe Leu Val Thr Ile
        275                 280                 285             
Gln Arg Ala Thr Val Trp Met Leu Gln Leu Glu Pro Leu His Thr Gln
    290                 295                 300                 
Asn Thr Gln Gln Glu Ala Leu Thr Thr Ala His Leu Glu Ala Thr Leu
305                 310                 315                 320 
Glu Glu Ala Gly Pro Ser Pro Pro Thr Phe His Cys Glu Val Val Gln
                325                 330                 335     
Ala Pro Arg Lys Gly Asn Phe Gln Leu Gln Gly Thr Met Leu Ser Asp
            340                 345                 350         
Gly Gln Gly Phe Thr Gln Asp Asp Val Gln Ala Ala Glu Val Thr Tyr
        355                 360                 365             
Gly Ala Met Ala Arg Ala Ser Val Ala Val Glu Asp Thr Phe Cys Phe
    370                 375                 380                 
His Val Thr Ala Pro Pro Tyr Phe Ser Pro Leu Cys Thr Phe Ser Ile
385                 390                 395                 400 
His Ile Gly Gly Asp Pro Asp Met Pro Val Leu Thr Asn Val Leu Val
                405                 410                 415     
Val Pro Glu Gly Gly Gly Cys Val Leu Ser Ala Asp Gln Leu Phe Val
            420                 425                 430         
Lys Ser Leu Asn Ser Ala Arg Tyr Leu Tyr Glu Val Met
        435                 440                 445 


<210> 7015
<211> 391
<212> PRT
<213> Homo sapiens

<400> 7015
Met Ser Arg Glu Pro Thr Pro Pro Leu Pro Gly Asp Met Ser Thr Gly
 1               5                  10                  15      
Pro Ile Ala Glu Ser Trp Cys Tyr Thr Gln Val Lys Val Val Lys Phe
            20                  25                  30          
Ser Tyr Met Trp Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met
        35                  40                  45              
Gly Glu Val Leu Lys Ser Ser Thr Phe Ser Ser Gly Pro Ser Asp Lys
    50                  55                  60                  
Met Lys Trp Cys Leu Arg Val Asn Pro Lys Gly Leu Asp Asp Glu Ser
65                  70                  75                  80  
Lys Asp Tyr Leu Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser
                85                  90                  95      
Glu Val Arg Ala Lys Phe Lys Phe Ser Leu Leu Asn Ala Lys Arg Glu
            100                 105                 110         
Glu Thr Lys Ala Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly
        115                 120                 125             
Lys Asp Trp Gly Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp
    130                 135                 140                 
Glu Ala Asn Gly Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu
145                 150                 155                 160 
Val Ser Val Val Gln Asp Ser Val Asn Ile Ser Gly His Thr Asn Thr
                165                 170                 175     
Asn Thr Leu Lys Val Pro Glu Cys Arg Leu Ala Glu Asp Leu Gly Asn
            180                 185                 190         
Leu Trp Glu Asn Thr Arg Phe Thr Asp Cys Ser Phe Phe Val Arg Gly
        195                 200                 205             
Gln Glu Phe Lys Ala His Lys Ser Val Leu Ala Ala Arg Ser Pro Val
    210                 215                 220                 
Phe Asn Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg
225                 230                 235                 240 
Val Glu Ile Asn Asp Leu Asp Pro Glu Val Phe Lys Glu Met Met Arg
                245                 250                 255     
Phe Ile Tyr Thr Gly Arg Ala Pro Asn Leu Asp Lys Met Ala Asp Asn
            260                 265                 270         
Leu Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met
        275                 280                 285             
Cys Glu Glu Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Val Ala Asp
    290                 295                 300                 
Thr Leu Val Leu Ala Asp Leu His Ser Ala Glu Gln Leu Lys Ala Gln
305                 310                 315                 320 
Ala Ile Asp Phe Ile Asn Arg Cys Ser Val Leu Arg Gln Leu Gly Cys
                325                 330                 335     
Lys Asp Gly Lys Asn Trp Asn Ser Asn Gln Ala Thr Asp Ile Met Glu
            340                 345                 350         
Ser Glu Arg Asp Arg Gln His Phe Asp Lys Glu Val Met Lys Ala Tyr
        355                 360                 365             
Ile Glu Asp Leu Lys Glu Arg Glu Ser Val Pro Ser Tyr Thr Thr Lys
    370                 375                 380                 
Val Ser Phe Ser Leu Gln Leu
385                 390     


<210> 7016
<211> 239
<212> PRT
<213> Homo sapiens

<400> 7016
Met Pro Lys Ser Cys Ala Ala Arg Gln Cys Cys Asn Arg Tyr Ser Ser
 1               5                  10                  15      
Arg Arg Lys Gln Leu Thr Phe His Arg Phe Pro Phe Ser Arg Pro Glu
            20                  25                  30          
Leu Leu Lys Glu Trp Val Leu Asn Ile Gly Arg Gly Asn Phe Lys Pro
        35                  40                  45              
Lys Gln His Thr Val Ile Cys Ser Glu His Phe Arg Pro Glu Cys Phe
    50                  55                  60                  
Ser Ala Phe Gly Asn Arg Lys Asn Leu Lys His Asn Ala Val Pro Thr
65                  70                  75                  80  
Val Phe Ala Phe Gln Asp Pro Thr Gln Gln Val Arg Glu Asn Thr Asp
                85                  90                  95      
Pro Ala Ser Glu Arg Gly Asn Ala Ser Ser Ser Gln Lys Glu Lys Val
            100                 105                 110         
Leu Pro Glu Ala Gly Ala Gly Glu Asp Ser Pro Gly Arg Asn Met Asp
        115                 120                 125             
Thr Ala Leu Glu Glu Leu Gln Leu Pro Pro Asn Ala Glu Gly His Val
    130                 135                 140                 
Lys Gln Val Ser Pro Arg Arg Pro Gln Ala Thr Glu Ala Val Gly Arg
145                 150                 155                 160 
Pro Thr Gly Pro Ala Gly Leu Arg Arg Thr Pro Asn Lys Gln Pro Ser
                165                 170                 175     
Asp His Ser Tyr Ala Leu Leu Asp Leu Asp Ser Leu Lys Lys Lys Leu
            180                 185                 190         
Phe Leu Thr Leu Lys Glu Asn Glu Lys Leu Arg Lys Arg Leu Gln Ala
        195                 200                 205             
Gln Arg Leu Val Met Arg Arg Met Ser Ser Arg Leu Arg Ala Cys Lys
    210                 215                 220                 
Gly His Gln Gly Leu Gln Ala Arg Leu Gly Pro Glu Gln Gln Ser
225                 230                 235                 


<210> 7017
<211> 434
<212> PRT
<213> Homo sapiens

<400> 7017
Met Ser Ser Phe Glu Gly Gln Met Ala Glu Tyr Pro Thr Ile Ser Ile
 1               5                  10                  15      
Asp Arg Phe Asp Arg Glu Asn Leu Arg Ala Arg Ala Tyr Phe Leu Ser
            20                  25                  30          
His Cys His Lys Asp His Met Lys Gly Leu Arg Ala Pro Thr Leu Lys
        35                  40                  45              
Arg Arg Leu Glu Cys Ser Leu Lys Val Tyr Leu Tyr Cys Ser Pro Val
    50                  55                  60                  
Thr Lys Glu Leu Leu Leu Thr Ser Pro Lys Tyr Arg Phe Trp Lys Lys
65                  70                  75                  80  
Arg Ile Ile Ser Ile Glu Ile Glu Thr Pro Thr Gln Ile Ser Leu Val
                85                  90                  95      
Asp Glu Ala Ser Gly Glu Lys Glu Glu Ile Val Val Thr Leu Leu Pro
            100                 105                 110         
Ala Gly His Cys Pro Gly Ser Val Met Phe Leu Phe Gln Gly Asn Asn
        115                 120                 125             
Gly Thr Val Leu Tyr Thr Gly Asp Phe Arg Leu Ala Gln Gly Glu Ala
    130                 135                 140                 
Ala Arg Met Glu Leu Leu His Ser Gly Gly Arg Val Lys Asp Ile Gln
145                 150                 155                 160 
Ser Val Tyr Leu Asp Thr Thr Phe Cys Asp Pro Arg Phe Tyr Gln Ile
                165                 170                 175     
Pro Ser Arg Glu Glu Cys Leu Ser Gly Val Leu Glu Leu Val Arg Ser
            180                 185                 190         
Trp Ile Thr Arg Ser Pro Tyr His Val Val Trp Leu Asn Cys Lys Ala
        195                 200                 205             
Ala Tyr Gly Tyr Glu Tyr Leu Phe Thr Asn Leu Ser Glu Glu Leu Gly
    210                 215                 220                 
Val Gln Val His Val Asn Lys Leu Asp Met Phe Arg Asn Met Pro Glu
225                 230                 235                 240 
Ile Leu Arg His Leu Thr Thr Asp Arg Asn Thr Gln Ile His Ala Cys
                245                 250                 255     
Arg His Pro Lys Ala Glu Glu Tyr Phe Gln Trp Ser Lys Leu Pro Cys
            260                 265                 270         
Gly Ile Thr Ser Arg Asn Arg Ile Pro Leu His Ile Ile Ser Ile Lys
        275                 280                 285             
Pro Ser Thr Met Trp Phe Gly Glu Arg Ser Arg Lys Thr Asn Val Ile
    290                 295                 300                 
Val Arg Thr Gly Glu Ser Ser Tyr Arg Ala Cys Phe Ser Phe His Ser
305                 310                 315                 320 
Ser Tyr Ser Glu Ile Lys Asp Phe Leu Ser Tyr Leu Cys Pro Val Asn
                325                 330                 335     
Ala Tyr Pro Asn Val Ile Pro Val Gly Thr Thr Met Asp Lys Val Val
            340                 345                 350         
Glu Ile Leu Lys Pro Leu Cys Arg Ser Ser Gln Ser Thr Glu Pro Lys
        355                 360                 365             
Tyr Lys Pro Leu Gly Lys Leu Lys Arg Ala Arg Thr Val His Arg Asp
    370                 375                 380                 
Ser Gly Ser His Ser Val Thr Gln Ala Arg Met Arg Trp Cys His His
385                 390                 395                 400 
Asp Ser Leu Tyr Pro Leu Thr Pro Gly Ile Lys Arg Ser Ser Cys Leu
                405                 410                 415     
Ser Leu Leu Thr Ser Trp Ile Thr Gly Ala Tyr Arg His Ala Gln Leu
            420                 425                 430         
Met Ile
        


<210> 7018
<211> 692
<212> PRT
<213> Homo sapiens

<400> 7018
Met Ser Ser Phe Glu Gly Gln Met Ala Glu Tyr Pro Thr Ile Ser Ile
 1               5                  10                  15      
Asp Arg Phe Asp Arg Glu Asn Leu Arg Ala Arg Ala Tyr Phe Leu Ser
            20                  25                  30          
His Cys His Lys Asp His Met Lys Gly Leu Arg Ala Pro Thr Leu Lys
        35                  40                  45              
Arg Arg Leu Glu Cys Ser Leu Lys Val Tyr Leu Tyr Cys Ser Pro Val
    50                  55                  60                  
Thr Lys Glu Leu Leu Leu Thr Ser Pro Lys Tyr Arg Phe Trp Lys Lys
65                  70                  75                  80  
Arg Ile Ile Ser Ile Glu Ile Glu Thr Pro Thr Gln Ile Ser Leu Val
                85                  90                  95      
Asp Glu Ala Ser Gly Glu Lys Glu Glu Ile Val Val Thr Leu Leu Pro
            100                 105                 110         
Ala Gly His Cys Pro Gly Ser Val Met Phe Leu Phe Gln Gly Asn Asn
        115                 120                 125             
Gly Thr Val Leu Tyr Thr Gly Asp Phe Arg Leu Ala Gln Gly Glu Ala
    130                 135                 140                 
Ala Arg Met Glu Leu Leu His Ser Gly Gly Arg Val Lys Asp Ile Gln
145                 150                 155                 160 
Ser Val Tyr Leu Asp Thr Thr Phe Cys Asp Pro Arg Phe Tyr Gln Ile
                165                 170                 175     
Pro Ser Arg Glu Glu Cys Leu Ser Gly Val Leu Glu Leu Val Arg Ser
            180                 185                 190         
Trp Ile Thr Arg Ser Pro Tyr His Val Val Trp Leu Asn Cys Lys Ala
        195                 200                 205             
Ala Tyr Gly Tyr Glu Tyr Leu Phe Thr Asn Leu Ser Glu Glu Leu Gly
    210                 215                 220                 
Val Gln Val His Val Asn Lys Leu Asp Met Phe Arg Asn Met Pro Glu
225                 230                 235                 240 
Ile Leu His His Leu Thr Thr Asp Arg Asn Thr Gln Ile His Ala Cys
                245                 250                 255     
Arg His Pro Lys Ala Glu Glu Tyr Phe Gln Trp Ser Lys Leu Pro Cys
            260                 265                 270         
Gly Ile Thr Ser Arg Asn Arg Ile Pro Leu His Ile Ile Ser Ile Lys
        275                 280                 285             
Pro Ser Thr Met Trp Phe Gly Glu Arg Ser Arg Lys Thr Asn Val Ile
    290                 295                 300                 
Val Arg Thr Gly Glu Ser Ser Tyr Arg Ala Cys Phe Ser Phe His Ser
305                 310                 315                 320 
Ser Tyr Ser Glu Ile Lys Asp Phe Leu Ser Tyr Leu Cys Pro Val Asn
                325                 330                 335     
Ala Tyr Pro Asn Val Ile Pro Val Gly Thr Thr Met Asp Lys Val Val
            340                 345                 350         
Glu Ile Leu Lys Pro Leu Cys Arg Ser Ser Gln Ser Thr Glu Pro Lys
        355                 360                 365             
Tyr Lys Pro Leu Gly Lys Leu Lys Arg Ala Arg Thr Val His Arg Asp
    370                 375                 380                 
Ser Glu Glu Glu Asp Asp Tyr Leu Phe Asp Asp Pro Leu Pro Ile Pro
385                 390                 395                 400 
Leu Arg His Lys Val Pro Tyr Pro Glu Thr Phe His Pro Glu Val Phe
                405                 410                 415     
Ser Met Thr Ala Val Ser Glu Lys Gln Pro Glu Lys Leu Arg Gln Thr
            420                 425                 430         
Pro Gly Cys Cys Arg Ala Glu Cys Met Gln Ser Ser Arg Phe Thr Asn
        435                 440                 445             
Phe Val Asp Cys Glu Glu Ser Asn Ser Glu Ser Glu Glu Glu Val Gly
    450                 455                 460                 
Ile Pro Ala Ser Leu Gln Gly Asp Leu Gly Ser Val Leu His Leu Gln
465                 470                 475                 480 
Lys Ala Asp Gly Asp Val Pro Gln Trp Glu Val Phe Phe Lys Arg Asn
                485                 490                 495     
Asp Glu Ile Thr Asp Glu Ser Leu Glu Asn Phe Pro Ser Ser Thr Val
            500                 505                 510         
Ala Gly Gly Ser Gln Ser Pro Lys Leu Phe Ser Asp Ser Asp Gly Glu
        515                 520                 525             
Ser Thr His Ile Ser Ser Gln Asn Ser Ser Gln Ser Thr His Ile Thr
    530                 535                 540                 
Glu Gln Gly Ser Gln Gly Trp Asp Ser Gln Ser Asp Thr Val Leu Val
545                 550                 555                 560 
Ser Ser Gln Glu Arg Asn Ser Gly Asp Ile Thr Ser Leu Asp Lys Ala
                565                 570                 575     
Asp Tyr Arg Pro Thr Ile Lys Glu Asn Ile Pro Ala Ser Leu Met Glu
            580                 585                 590         
Gln Asn Val Ile Cys Pro Lys Asp Thr Tyr Ser Asp Leu Lys Ser Arg
        595                 600                 605             
Asp Lys Asp Val Thr Ile Val Pro Ser Thr Gly Glu Pro Thr Thr Leu
    610                 615                 620                 
Ser Ser Glu Thr His Ile Pro Glu Glu Lys Ser Leu Leu Asn Leu Ser
625                 630                 635                 640 
Thr Asn Ala Asp Ser Gln Ser Ser Ser Asp Phe Glu Val Pro Ser Thr
                645                 650                 655     
Pro Glu Ala Glu Leu Pro Lys Arg Glu His Leu Gln Tyr Leu Tyr Glu
            660                 665                 670         
Lys Leu Ala Thr Gly Glu Ser Ile Ala Val Lys Lys Arg Lys Cys Ser
        675                 680                 685             
Leu Leu Asp Thr
    690         


<210> 7019
<211> 213
<212> PRT
<213> Homo sapiens

<400> 7019
Met Pro Ala Thr Pro Pro Pro Pro Lys Leu Lys Glu Ala Gly Lys Glu
 1               5                  10                  15      
Ser Val Val Ser Arg Leu Val Cys Pro Asn Thr Asn Pro Asn Asp Thr
            20                  25                  30          
Pro Thr Tyr Val Leu Glu Met Glu Glu Ala Gly Ser Ile Phe Ala Cys
        35                  40                  45              
Asn Met Glu Gly Arg Ser Asn Ser Ser Gly Glu Val Lys Tyr Thr Thr
    50                  55                  60                  
Cys Pro Asp Lys Thr Gly Ser Pro Arg Lys Pro Tyr Ile Lys Gly Lys
65                  70                  75                  80  
Val His Ala His Ser Val Lys Ile Gly Trp Lys Pro Ser Lys Asp Asn
                85                  90                  95      
Gly Gly Thr Tyr Ile Ser Ser Tyr Ser Leu Glu Val Ser Glu Asn Ser
            100                 105                 110         
Asp Asp Asn Tyr Leu Ala Asn Gly Asn Pro Glu Glu Leu Val Tyr Val
        115                 120                 125             
Lys Lys Ala Asn Gly Asn Gln Asp Asp Thr Gln Gly His Pro Gly Ser
    130                 135                 140                 
Asp Val Lys Tyr Arg Leu Ser Lys Leu Ile Pro Ile Pro Val Cys Asn
145                 150                 155                 160 
Gly Ala Glu Ile Thr Asp Tyr Arg Leu Glu Cys Gly Gln Ile Glu Lys
                165                 170                 175     
Ser Val His Leu Ile Tyr Thr Gly Pro Cys Leu Ser Tyr Glu Val Lys
            180                 185                 190         
Gly Leu Ile Pro Ala Thr Thr Tyr Phe Cys Arg Val Gln Val Asn Leu
        195                 200                 205             
Thr Val Pro Pro Met
    210             


<210> 7020
<211> 1379
<212> PRT
<213> Homo sapiens

<400> 7020
His Leu Cys Val Leu Ala Phe Ser Phe Phe Lys Ile Ser Phe His Asp
 1               5                  10                  15      
Ser Glu Val Ser Gly Ile Lys Thr Val Arg Met Ser Ser Pro Met Pro
            20                  25                  30          
Asp Cys Thr Ser Lys Cys Arg Ser Leu Lys His Ala Leu Asp Val Leu
        35                  40                  45              
Ser Val Val Thr Lys Gly Ser Glu Asn Gln Ile Lys Ala Phe Leu Ser
    50                  55                  60                  
Ser His Cys Tyr Asn Ala Ala Thr Ile Lys Asp Val Phe Gly Arg Asn
65                  70                  75                  80  
Ala Leu His Leu Val Ser Ser Cys Gly Lys Lys Gly Val Leu Asp Trp
                85                  90                  95      
Leu Ile Gln Lys Gly Val Asp Leu Leu Val Lys Asp Lys Glu Ser Gly
            100                 105                 110         
Trp Thr Ala Leu His Arg Ser Ile Phe Tyr Gly His Ile Asp Cys Val
        115                 120                 125             
Trp Ser Leu Leu Lys His Gly Val Ser Leu Tyr Ile Gln Asp Lys Glu
    130                 135                 140                 
Gly Leu Ser Ala Leu Asp Leu Val Met Lys Asp Arg Pro Thr His Val
145                 150                 155                 160 
Val Phe Lys Asn Thr Asp Pro Thr Asp Val Tyr Thr Trp Gly Asp Asn
                165                 170                 175     
Thr Asn Phe Thr Leu Gly His Gly Ser Gln Asn Ser Lys His His Pro
            180                 185                 190         
Glu Leu Val Asp Leu Phe Ser Arg Ser Gly Ile Tyr Ile Lys Gln Val
        195                 200                 205             
Val Leu Cys Lys Phe His Ser Val Phe Leu Ser Gln Lys Gly Gln Val
    210                 215                 220                 
Tyr Thr Cys Gly His Gly Pro Gly Gly Arg Leu Gly His Gly Asp Glu
225                 230                 235                 240 
Gln Thr Cys Leu Val Pro Arg Leu Val Glu Gly Leu Asn Gly His Asn
                245                 250                 255     
Cys Ser Gln Val Ala Ala Ala Lys Asp His Thr Val Val Leu Thr Glu
            260                 265                 270         
Asp Gly Cys Val Tyr Thr Phe Gly Leu Asn Ile Phe His Gln Leu Gly
        275                 280                 285             
Ile Ile Pro Pro Pro Ser Ser Cys Asn Val Pro Arg Gln Ile Gln Ala
    290                 295                 300                 
Lys Tyr Leu Lys Gly Arg Thr Ile Ile Gly Val Ala Ala Gly Arg Phe
305                 310                 315                 320 
His Thr Val Leu Trp Thr Arg Glu Ala Val Tyr Thr Met Gly Leu Asn
                325                 330                 335     
Gly Gly Gln Leu Gly Cys Leu Leu Asp Pro Asn Gly Glu Lys Cys Val
            340                 345                 350         
Thr Ala Pro Arg Gln Val Ser Ala Leu His His Lys Asp Ile Ala Leu
        355                 360                 365             
Ser Leu Val Ala Ala Ser Asp Gly Ala Thr Val Cys Val Thr Thr Arg
    370                 375                 380                 
Gly Asp Ile Tyr Leu Leu Ala Asp Tyr Gln Cys Lys Lys Met Ala Ser
385                 390                 395                 400 
Lys Gln Leu Asn Leu Lys Lys Val Leu Val Ser Gly Gly His Met Glu
                405                 410                 415     
Tyr Lys Val Asp Pro Glu His Leu Lys Glu Asn Gly Gly Gln Lys Ile
            420                 425                 430         
Cys Ile Leu Ala Met Asp Gly Ala Gly Arg Val Phe Cys Trp Arg Ser
        435                 440                 445             
Val Asn Ser Ser Leu Lys Gln Cys Arg Trp Ala Tyr Pro Arg Gln Val
    450                 455                 460                 
Phe Ile Ser Asp Ile Ala Leu Asn Arg Asn Glu Ile Leu Phe Val Thr
465                 470                 475                 480 
Gln Asp Gly Glu Gly Phe Arg Gly Arg Trp Phe Glu Glu Lys Arg Lys
                485                 490                 495     
Ser Ser Glu Lys Lys Glu Ile Leu Ser Asn Leu His Asn Ser Ser Ser
            500                 505                 510         
Asp Val Ser Tyr Val Ser Asp Ile Asn Ser Val Tyr Glu Arg Ile Arg
        515                 520                 525             
Leu Glu Lys Leu Thr Phe Ala His Arg Ala Val Ser Val Ser Thr Asp
    530                 535                 540                 
Pro Ser Gly Cys Asn Phe Ala Ile Leu Gln Ser Asp Pro Lys Thr Ser
545                 550                 555                 560 
Leu Tyr Glu Ile Pro Ala Val Ser Ser Ser Ser Phe Phe Glu Glu Phe
                565                 570                 575     
Gly Lys Leu Leu Arg Glu Ala Asp Glu Met Asp Ser Ile His Asp Val
            580                 585                 590         
Thr Phe Gln Val Gly Asn Arg Leu Phe Pro Ala His Lys Tyr Ile Leu
        595                 600                 605             
Ala Val His Ser Asp Phe Phe Gln Lys Leu Phe Leu Ser Asp Gly Asn
    610                 615                 620                 
Thr Ser Glu Phe Thr Asp Ile Tyr Gln Lys Asp Glu Asp Ser Ala Gly
625                 630                 635                 640 
Cys His Leu Phe Val Val Glu Lys Val His Pro Asp Met Phe Glu Tyr
                645                 650                 655     
Leu Leu Gln Phe Ile Tyr Thr Asp Thr Cys Asp Phe Leu Thr His Gly
            660                 665                 670         
Phe Lys Pro Arg Ile His Leu Asn Lys Asn Pro Glu Glu Tyr Gln Gly
        675                 680                 685             
Thr Leu Asn Ser His Leu Asn Lys Val Asn Phe His Glu Asp Asp Asn
    690                 695                 700                 
Gln Lys Ser Ala Phe Glu Val Tyr Lys Ser Asn Gln Ala Gln Thr Val
705                 710                 715                 720 
Ser Glu Arg Gln Lys Ser Lys Pro Lys Ser Cys Lys Lys Gly Lys Asn
                725                 730                 735     
Ile Arg Glu Asp Asp Pro Val Arg Met Leu Gln Thr Val Ala Lys Lys
            740                 745                 750         
Phe Asp Phe Ser Asn Leu Ser Ser Arg Leu Asp Gly Val Arg Phe Glu
        755                 760                 765             
Asn Glu Lys Ile Asn Val Ile Ala Lys Asn Thr Gly Asn Lys Leu Lys
    770                 775                 780                 
Leu Ser Gln Lys Lys Cys Ser Phe Leu Cys Asp Val Thr Met Lys Ser
785                 790                 795                 800 
Val Asp Gly Lys Glu Phe Pro Cys His Lys Cys Val Leu Cys Ala Arg
                805                 810                 815     
Leu Glu Tyr Phe His Ser Met Leu Ser Ser Ser Trp Ile Glu Ala Ser
            820                 825                 830         
Ser Cys Ala Ala Leu Glu Met Pro Ile His Ser Asp Ile Leu Lys Val
        835                 840                 845             
Ile Leu Asp Tyr Leu Tyr Thr Asp Glu Ala Val Val Ile Lys Glu Ser
    850                 855                 860                 
Gln Asn Val Asp Phe Ile Cys Ser Val Leu Val Val Ala Asp Gln Leu
865                 870                 875                 880 
Leu Ile Thr Arg Leu Lys Glu Ile Cys Glu Val Ala Leu Thr Glu Lys
                885                 890                 895     
Leu Thr Leu Lys Asn Ala Ala Met Leu Leu Glu Phe Ala Ala Met Tyr
            900                 905                 910         
Ser Ala Lys Gln Leu Lys Leu Ser Cys Leu Gln Phe Ile Gly Leu Asn
        915                 920                 925             
Met Ala Ala Leu Leu Glu Ala Arg Ser Leu Asp Val Leu Ser Asp Gly
    930                 935                 940                 
Val Leu Lys Asp Leu Ser Glu Phe Tyr Arg Lys Met Ile Pro Ala Met
945                 950                 955                 960 
Asp Arg Arg Val Ile Thr Pro Tyr Gln Asp Gly Pro Asp Ile Ser Tyr
                965                 970                 975     
Leu Glu Val Glu Asp Gly Asp Ile Phe Leu Lys Glu Glu Ile Asn Met
            980                 985                 990         
Glu Gln Asn His Ser Glu Thr Met Phe Lys Lys Ala Lys Thr Lys Ala
        995                 1000                1005            
Lys Lys Lys Pro Arg Lys Arg Ser Asp Ser Ser Gly Gly Tyr Asn Leu
    1010                1015                1020                
Ser Asp Ile Ile Gln Ser Pro Ser Ser Thr Gly Leu Leu Lys Ser Gly
1025                1030                1035                1040
Lys Thr Asn Ser Val Glu Ser Leu Pro Glu Leu Leu Thr Ser Asp Ser
                1045                1050                1055    
Glu Gly Ser Tyr Ala Gly Val Gly Ser Pro Arg Asp Leu Gln Ser Pro
            1060                1065                1070        
Asp Phe Thr Thr Gly Phe His Ser Asp Lys Ile Glu Ala Lys Val Lys
        1075                1080                1085            
Pro Tyr Val Asn Gly Thr Ser Pro Val Tyr Ser Arg Glu Asp Leu Lys
    1090                1095                1100                
Pro Trp Glu Lys Ser Pro Ile Leu Lys Ile Ser Ala Pro Gln Pro Ile
1105                1110                1115                1120
Pro Ser Asn Arg Ile Asp Thr Thr Ser Ser Ala Ser Trp Val Ala Gly
                1125                1130                1135    
Ser Phe Ser Pro Val Ser Pro Pro Val Val Asp Leu Arg Thr Ile Met
            1140                1145                1150        
Glu Ile Glu Glu Ser Arg Gln Lys Cys Gly Ala Thr Pro Lys Ser His
        1155                1160                1165            
Leu Gly Lys Thr Val Ser His Gly Val Lys Leu Ser Gln Lys Gln Arg
    1170                1175                1180                
Lys Met Ile Ala Leu Thr Thr Lys Glu Asn Asn Ser Gly Met Asn Ser
1185                1190                1195                1200
Met Glu Thr Val Leu Phe Thr Pro Ser Lys Ala Pro Lys Pro Val Asn
                1205                1210                1215    
Ala Trp Ala Ser Ser Leu His Ser Val Ser Ser Lys Ser Phe Arg Asp
            1220                1225                1230        
Phe Leu Leu Glu Glu Lys Lys Ser Val Thr Ser His Ser Ser Gly Asp
        1235                1240                1245            
His Val Lys Lys Val Ser Phe Lys Gly Ile Glu Asn Ser Gln Ala Pro
    1250                1255                1260                
Lys Ile Val Arg Cys Ser Thr His Gly Thr Pro Gly Pro Glu Gly Asn
1265                1270                1275                1280
His Ile Ser Asp Leu Pro Leu Leu Asp Ser Pro Asn Pro Trp Leu Ser
                1285                1290                1295    
Ser Ser Val Thr Ala Pro Ser Met Val Ala Pro Val Thr Phe Ala Ser
            1300                1305                1310        
Ile Val Glu Glu Glu Leu Gln Gln Glu Ala Ala Leu Ile Arg Ser Arg
        1315                1320                1325            
Glu Lys Pro Leu Ala Leu Ile Gln Ile Glu Glu His Ala Ile Gln Asp
    1330                1335                1340                
Leu Leu Val Phe Tyr Glu Ala Phe Gly Asn Pro Glu Glu Phe Val Ile
1345                1350                1355                1360
Val Glu Arg Thr Pro Gln Gly Pro Leu Ala Val Pro Met Trp Asn Lys
                1365                1370                1375    
His Gly Cys
            


<210> 7021
<211> 536
<212> PRT
<213> Homo sapiens

<400> 7021
Met Lys Lys Ser Glu Thr Tyr Ala Pro Leu Phe Cys Leu Pro Ser Phe
 1               5                  10                  15      
His Lys Phe Cys Lys Gly Leu Leu Ala Asn Ile Leu Val Glu Asp Val
            20                  25                  30          
Asn Ile Cys Leu Gln Ala Cys Ser Ser Leu Pro Ala Leu Ser Ser Ser
        35                  40                  45              
Leu Pro Asp Asp Leu Leu Gln Arg Cys Val Asp Val Cys His Val Gln
    50                  55                  60                  
Leu Val His Cys Gly Thr Arg Ile Arg Gln Ala Phe Gly Lys Leu Leu
65                  70                  75                  80  
Lys Ser Ile Pro Leu Asp Val Ile Leu Ser Asn Asn Asn His Thr Glu
                85                  90                  95      
Ile Gln Glu Ile Ser Leu Ala Leu Arg Ser His Met Ser Lys Ala Pro
            100                 105                 110         
Ser Asn Thr Phe His Pro Gln Asp Phe Ser Asp Val Ile Ser Phe Ile
        115                 120                 125             
Leu Tyr Gly Asn Ser His Arg Thr Gly Lys Asp Asn Trp Leu Glu Arg
    130                 135                 140                 
Leu Phe Tyr Ser Cys Gln Arg Leu Asp Lys His Asp Gln Ser Thr Ile
145                 150                 155                 160 
Pro Arg Asn Leu Leu Lys Thr Asp Ala Ile Leu Trp Gln Trp Ala Val
                165                 170                 175     
Trp Glu Ala Ala Gln Phe Thr Val Leu Ser Lys Leu Arg Thr Pro Leu
            180                 185                 190         
Gly Arg Ala Gln Asp Thr Phe Gln Thr Ile Glu Gly Ile Ile Arg Ser
        195                 200                 205             
Leu Ala Ala His Thr Leu Asn Pro Asp Gln Asp Val Ser Gln Trp Thr
    210                 215                 220                 
Thr Ala Asp Ser Asp Glu Gly His Gly Asn Asn Gln Leu Arg Leu Val
225                 230                 235                 240 
Leu Leu Leu Gln Tyr Leu Glu Tyr Leu Glu Lys Leu Met Tyr Asn Ala
                245                 250                 255     
Tyr Glu Gly Cys Ala Asn Ala Leu Thr Ser Pro Pro Lys Val Ile Arg
            260                 265                 270         
Thr Phe Phe Tyr Thr Asn Arg Gln Thr Cys Gln Asp Trp Leu Thr Arg
        275                 280                 285             
Ile Arg Leu Ser Ile Met Arg Val Gly Leu Leu Ala Gly Gln Pro Ala
    290                 295                 300                 
Val Thr Val Arg His Gly Phe Asp Leu Leu Thr Glu Met Lys Thr Thr
305                 310                 315                 320 
Ser Leu Ser Gln Gly Asn Glu Leu Glu Val Thr Ile Met Met Val Val
                325                 330                 335     
Glu Ala Leu Cys Glu Leu His Cys Pro Glu Ala Ile Gln Gly Ile Ala
            340                 345                 350         
Val Trp Ser Ser Ser Ile Val Gly Lys Asn Leu Leu Trp Ile Asn Ser
        355                 360                 365             
Val Ala Gln Gln Ala Glu Gly Arg Phe Glu Lys Ala Ser Val Glu Tyr
    370                 375                 380                 
Gln Glu His Leu Cys Ala Met Ile Gly Val His Cys Cys Ile Ser Ser
385                 390                 395                 400 
Phe Asp Lys Ser Val Leu Thr Leu Ala Asn Ala Gly Cys Asn Ser Ala
                405                 410                 415     
Ser Pro Lys His Cys Leu Asn Gly Glu Ser Arg Lys Thr Val Leu Ser
            420                 425                 430         
Lys Pro Thr Asp Ser Ser Pro Glu Val Ile Asn Tyr Leu Gly Asn Lys
        435                 440                 445             
Ala Cys Glu Cys Tyr Ile Ser Ile Ala Asp Trp Ala Ala Val Gln Glu
    450                 455                 460                 
Trp Gln Asn Ala Ile His Asp Leu Lys Lys Ser Thr Ser Ser Thr Ser
465                 470                 475                 480 
Phe Asn Leu Lys Ala Asp Phe Asn Tyr Ile Lys Ser Leu Ser Ser Phe
                485                 490                 495     
Glu Ser Gly Lys Phe Val Lys Cys Thr Glu Gln Leu Glu Leu Leu Pro
            500                 505                 510         
Gly Glu Asn Ile Asn Leu Leu Ala Gly Gly Ser Lys Glu Lys Ile Asp
        515                 520                 525             
Met Lys Lys Leu Leu Arg Asn Met
    530                 535     


<210> 7022
<211> 285
<212> PRT
<213> Homo sapiens

<400> 7022
Met Leu Tyr Leu Ile Gly Leu Gly Leu Gly Asp Ala Lys Asp Ile Thr
 1               5                  10                  15      
Val Lys Gly Leu Glu Val Val Arg Arg Cys Ser Arg Val Tyr Leu Glu
            20                  25                  30          
Ala Tyr Thr Ser Val Leu Thr Val Gly Lys Glu Ala Leu Glu Glu Phe
        35                  40                  45              
Tyr Gly Arg Lys Leu Val Val Ala Asp Arg Glu Glu Val Glu Gln Glu
    50                  55                  60                  
Ala Asp Asn Ile Leu Lys Asp Ala Asp Ile Ser Asp Val Ala Phe Leu
65                  70                  75                  80  
Val Val Gly Asp Pro Phe Gly Ala Thr Thr His Ser Asp Leu Val Leu
                85                  90                  95      
Arg Ala Thr Lys Leu Gly Ile Pro Tyr Arg Val Ile His Asn Ala Ser
            100                 105                 110         
Ile Met Asn Ala Glu Ala Ala Gly Gly Tyr Arg Tyr Ile Ser Leu Glu
        115                 120                 125             
Arg Gln Val Leu Leu Val Phe Gly Gln Thr Leu Gly Gly Pro Glu Ser
    130                 135                 140                 
Phe Phe Asp Lys Val Lys Lys Asn Arg Gln Asn Gly Met His Thr Leu
145                 150                 155                 160 
Cys Leu Leu Asp Ile Lys Val Lys Glu Gln Ser Leu Glu Asn Leu Ile
                165                 170                 175     
Lys Gly Arg Lys Ile Tyr Glu Pro Pro Arg Tyr Met Ser Val Asn Gln
            180                 185                 190         
Ala Ala Gln Gln Leu Leu Glu Ile Val Gln Asn Gln Arg Ile Arg Gly
        195                 200                 205             
Glu Glu Pro Ala Val Thr Glu Glu Thr Leu Cys Val Gly Leu Ala Arg
    210                 215                 220                 
Val Gly Ala Asp Asp Gln Lys Ile Ala Ala Gly Thr Leu Arg Gln Met
225                 230                 235                 240 
Cys Thr Val Asp Leu Gly Glu Pro Leu His Ser Leu Ile Ile Thr Gly
                245                 250                 255     
Gly Ser Ile His Pro Met Glu Met Glu Met Leu Ser Leu Phe Ser Ile
            260                 265                 270         
Pro Glu Asn Ser Ser Glu Ser Gln Ser Ile Asn Gly Leu
        275                 280                 285 


<210> 7023
<211> 1134
<212> PRT
<213> Homo sapiens

<400> 7023
Gly Leu Glu Met Asp Pro Ile Asp Cys Thr Pro Pro Glu Tyr Ile Leu
 1               5                  10                  15      
Pro Gly Ser Arg Glu Arg Pro Leu Cys Pro Leu Gln Pro Gln Asn Arg
            20                  25                  30          
Asp Trp Lys Pro Leu Gln Cys Leu Lys Val Leu Thr Met Ser Gly Trp
        35                  40                  45              
Asn Pro Pro Pro Gly Asn Arg Lys Met His Gly Asp Leu Met Tyr Leu
    50                  55                  60                  
Phe Val Ile Thr Ala Glu Asp Arg Gln Val Ser Ile Thr Ala Ser Thr
65                  70                  75                  80  
Arg Gly Phe Tyr Leu Asn Gln Ser Thr Ala Tyr His Phe Asn Pro Lys
                85                  90                  95      
Pro Ala Ser Pro Arg Phe Leu Ser His Ser Leu Val Glu Leu Leu Asn
            100                 105                 110         
Gln Ile Ser Pro Thr Phe Lys Lys Asn Phe Ala Val Leu Gln Lys Lys
        115                 120                 125             
Arg Val Gln Arg His Pro Phe Glu Arg Ile Ala Thr Pro Phe Gln Val
    130                 135                 140                 
Tyr Ser Trp Thr Ala Pro Gln Ala Glu His Ala Met Asp Cys Val Arg
145                 150                 155                 160 
Ala Glu Asp Ala Tyr Thr Ser Arg Leu Gly Tyr Glu Glu His Ile Pro
                165                 170                 175     
Gly Gln Thr Arg Asp Trp Asn Glu Glu Leu Gln Thr Thr Arg Glu Leu
            180                 185                 190         
Pro Arg Lys Asn Leu Pro Glu Arg Leu Leu Arg Glu Arg Ala Ile Phe
        195                 200                 205             
Lys Val His Ser Asp Phe Thr Ala Ala Ala Thr Arg Gly Ala Met Ala
    210                 215                 220                 
Val Ile Asp Gly Asn Val Met Ala Ile Asn Pro Ser Glu Glu Thr Lys
225                 230                 235                 240 
Met Gln Met Phe Ile Trp Asn Asn Ile Phe Phe Ser Leu Gly Phe Asp
                245                 250                 255     
Val Arg Asp His Tyr Lys Asp Phe Gly Gly Asp Val Ala Ala Tyr Val
            260                 265                 270         
Ala Pro Thr Asn Asp Leu Asn Gly Val Arg Thr Tyr Asn Ala Val Asp
        275                 280                 285             
Val Glu Gly Leu Tyr Thr Leu Gly Thr Val Val Val Asp Tyr Arg Gly
    290                 295                 300                 
Tyr Arg Val Thr Ala Gln Ser Ile Ile Pro Gly Ile Leu Glu Arg Asp
305                 310                 315                 320 
Gln Glu Gln Ser Val Ile Tyr Gly Ser Ile Asp Phe Gly Lys Thr Val
                325                 330                 335     
Val Ser His Pro Arg Tyr Leu Glu Leu Leu Glu Arg Thr Ser Arg Pro
            340                 345                 350         
Leu Lys Ile Leu Arg His Gln Val Leu Asn Asp Arg Asp Glu Glu Val
        355                 360                 365             
Glu Leu Cys Ser Ser Val Glu Cys Lys Gly Ile Ile Gly Asn Asp Gly
    370                 375                 380                 
Arg His Tyr Ile Leu Asp Leu Leu Arg Thr Phe Pro Pro Asp Leu Asn
385                 390                 395                 400 
Phe Leu Pro Val Pro Gly Glu Glu Leu Pro Glu Glu Cys Ala Arg Ala
                405                 410                 415     
Gly Phe Pro Arg Ala His Arg His Lys Leu Cys Cys Leu Arg Gln Glu
            420                 425                 430         
Leu Val Asp Ala Phe Val Glu His Arg Tyr Leu Leu Phe Met Lys Leu
        435                 440                 445             
Ala Ala Leu Gln Leu Met Gln Gln Asn Ala Ser Gln Leu Glu Thr Pro
    450                 455                 460                 
Ser Ser Leu Glu Asn Gly Gly Pro Ser Ser Leu Glu Ser Lys Ser Glu
465                 470                 475                 480 
Asp Pro Pro Gly Gln Glu Ala Gly Ser Glu Glu Glu Gly Ser Ser Ala
                485                 490                 495     
Ser Gly Leu Ala Lys Val Lys Glu Leu Ala Glu Thr Ile Ala Ala Asp
            500                 505                 510         
Asp Gly Thr Asp Pro Arg Ser Arg Glu Val Ile Arg Asn Ala Cys Lys
        515                 520                 525             
Ala Val Gly Ser Ile Ser Ser Thr Ala Phe Asp Ile Arg Phe Asn Pro
    530                 535                 540                 
Asp Ile Phe Ser Pro Gly Val Arg Phe Pro Glu Ser Cys Gln Asp Glu
545                 550                 555                 560 
Val Arg Asp Gln Lys Gln Leu Leu Lys Asp Ala Ala Ala Phe Leu Leu
                565                 570                 575     
Ser Cys Gln Ile Pro Gly Leu Val Lys Asp Cys Met Glu His Ala Val
            580                 585                 590         
Leu Pro Val Asp Gly Ala Thr Leu Ala Glu Val Met Arg Gln Arg Gly
        595                 600                 605             
Ile Asn Met Arg Tyr Leu Gly Lys Val Leu Glu Leu Val Leu Arg Ser
    610                 615                 620                 
Pro Ala Arg His Gln Leu Asp His Val Phe Lys Ile Gly Ile Gly Glu
625                 630                 635                 640 
Leu Ile Thr Arg Ser Ala Lys His Ile Phe Lys Thr Tyr Leu Gln Gly
                645                 650                 655     
Val Glu Leu Ser Gly Leu Ser Ala Ala Ile Ser His Phe Leu Asn Cys
            660                 665                 670         
Phe Leu Ser Ser Tyr Pro Asn Pro Val Ala His Leu Pro Ala Asp Glu
        675                 680                 685             
Leu Val Ser Lys Lys Arg Asn Lys Arg Arg Lys Asn Arg Pro Pro Gly
    690                 695                 700                 
Ala Ala Asp Asn Thr Ala Trp Ala Val Met Thr Pro Gln Glu Leu Trp
705                 710                 715                 720 
Lys Asn Ile Cys Gln Glu Ala Lys Asn Tyr Phe Asp Phe Asp Leu Glu
                725                 730                 735     
Cys Glu Thr Val Asp Gln Ala Val Glu Thr Tyr Gly Leu Gln Lys Ile
            740                 745                 750         
Thr Leu Leu Arg Glu Ile Ser Leu Lys Thr Gly Ile Gln Val Leu Leu
        755                 760                 765             
Lys Glu Tyr Ser Phe Asp Ser Arg His Lys Pro Ala Phe Thr Glu Glu
    770                 775                 780                 
Asp Val Leu Asn Ile Phe Pro Val Val Lys His Val Asn Pro Lys Ala
785                 790                 795                 800 
Ser Asp Ala Phe His Phe Phe Gln Ser Gly Gln Ala Lys Val Gln Gln
                805                 810                 815     
Gly Phe Leu Lys Glu Gly Cys Glu Leu Ile Asn Glu Ala Leu Asn Leu
            820                 825                 830         
Phe Asn Asn Val Tyr Gly Ala Met His Val Glu Thr Cys Ala Cys Leu
        835                 840                 845             
Arg Leu Leu Ala Arg Leu His Tyr Ile Met Gly Asp Tyr Ala Glu Ala
    850                 855                 860                 
Leu Ser Asn Gln Gln Lys Ala Val Leu Met Ser Glu Arg Val Met Gly
865                 870                 875                 880 
Thr Glu His Pro Asn Thr Ile Gln Glu Tyr Met His Leu Ala Leu Tyr
                885                 890                 895     
Cys Phe Ala Ser Ser Gln Leu Ser Thr Ala Leu Ser Leu Leu Tyr Arg
            900                 905                 910         
Ala Arg Tyr Leu Met Leu Leu Val Phe Gly Glu Asp His Pro Glu Met
        915                 920                 925             
Ala Leu Leu Asp Asn Asn Ile Gly Leu Val Leu His Gly Val Met Glu
    930                 935                 940                 
Tyr Asp Leu Ser Leu Arg Phe Leu Glu Asn Ala Leu Ala Val Ser Thr
945                 950                 955                 960 
Lys Tyr His Gly Pro Lys Ala Leu Lys Val Ala Leu Ser His His Leu
                965                 970                 975     
Val Ala Arg Val Tyr Glu Ser Lys Ala Glu Phe Arg Ser Ala Leu Gln
            980                 985                 990         
His Glu Lys Glu Gly Tyr Thr Ile Tyr Lys Thr Gln Leu Gly Glu Asp
        995                 1000                1005            
His Glu Lys Thr Lys Glu Ser Ser Glu Tyr Leu Lys Cys Leu Thr Gln
    1010                1015                1020                
Gln Ala Val Ala Leu Gln Arg Thr Met Asn Glu Ile Tyr Arg Asn Gly
1025                1030                1035                1040
Ser Ser Ala Asn Ile Pro Pro Leu Lys Phe Thr Ala Pro Ser Met Ala
                1045                1050                1055    
Ser Val Leu Glu Gln Leu Asn Val Ile Asn Gly Ile Leu Phe Ile Pro
            1060                1065                1070        
Leu Ser Gln Lys Asp Leu Glu Asn Leu Lys Ala Glu Val Ala Arg Arg
        1075                1080                1085            
His Gln Leu Gln Glu Ala Ser Arg Asn Arg Asp Arg Ala Glu Glu Pro
    1090                1095                1100                
Met Ala Thr Glu Pro Ala Pro Ala Gly Ala Pro Gly Asp Leu Gly Ser
1105                1110                1115                1120
Gln Pro Pro Ala Ala Lys Asp Pro Ser Pro Ser Val Gln Gly
                1125                1130                


<210> 7024
<211> 296
<212> PRT
<213> Homo sapiens

<400> 7024
Cys Cys Gly Ser Ala Ala Arg Trp Glu Phe Gly Phe Gly Trp Leu Gln
 1               5                  10                  15      
Pro Ala Ser Arg Val Lys Thr Pro Thr Pro Gly Ala Ala Gly Ser Thr
            20                  25                  30          
His Gly Asp Pro Arg Gly Ala Asp Trp Tyr Tyr His Val Pro Val Lys
        35                  40                  45              
Arg Ser Glu Lys Ala Val Asp Ala Pro Pro Ala Ser Gln Ile Pro Gly
    50                  55                  60                  
Leu Ser Asn Leu Gly Asp Ser His Ser Glu Asn Leu Pro Gly Thr Arg
65                  70                  75                  80  
Arg Tyr Trp Ile Lys Glu Thr Asp Ser Glu Tyr Val Lys Leu Ala Lys
                85                  90                  95      
Gln Gly Gly Arg Pro Asp Leu Leu Lys His Phe Ala Pro Gly Thr Arg
            100                 105                 110         
Lys Gly Ser Pro Val Ala Tyr Ser Leu Pro Asp Trp Tyr Ile His His
        115                 120                 125             
Ser Lys Pro Pro Thr Ala Ser Gln Gln Glu Val Arg Ala Val Ser Met
    130                 135                 140                 
Leu Asp Tyr Met Val His Glu Glu Phe Asn Pro Asn Gln Ala Asn Gly
145                 150                 155                 160 
Ser Tyr Ala Ser Arg Arg Gly Pro Phe Asp Phe Asp Thr Lys Thr Val
                165                 170                 175     
Trp Gln Arg Glu Ala Glu Glu Leu Glu Lys Glu Lys Lys Lys Leu Arg
            180                 185                 190         
Leu Pro Ala Ile Asp Ser Lys Tyr Leu Ser Lys Ala Gly Thr Pro Leu
        195                 200                 205             
Gly Pro Lys Asn Pro Ala Gly Ser Arg Leu Ser Phe Pro His Val Asn
    210                 215                 220                 
Gly Tyr Lys Asp Glu Trp Leu Gln Gln Gln Gln Arg Ala Asp Ser Asp
225                 230                 235                 240 
Lys Arg Thr Pro Lys Thr Ser Arg Ala Ser Val Leu Ser Gln Ser Pro
                245                 250                 255     
Arg Asp Leu Glu Gly Pro Gln Asp Ala Ala Arg Leu Gln Asp Ala Glu
            260                 265                 270         
Ala Ser Glu Gly Pro Glu Asp Thr Pro Gly Pro Glu Glu Ser Val Ser
        275                 280                 285             
Ala Ser Thr Pro Ala Glu Leu Lys
    290                 295     


<210> 7025
<211> 128
<212> PRT
<213> Homo sapiens

<400> 7025
Met Gln Ile Pro His Met Val Ser Glu Thr His Thr Val Trp Leu Glu
 1               5                  10                  15      
Asp Ser Thr Val Thr Ser Gln Ala Gln Pro Ser Ala Ser Pro Pro Leu
            20                  25                  30          
Ala Ala Leu Gly Cys Trp Pro Ser Ser Asp Gly Ser Arg Ala Gln Ser
        35                  40                  45              
Ala Val Ser Gln Glu Lys Pro Ala Ser Ser Leu Arg Gly Leu Glu Glu
    50                  55                  60                  
Pro Phe Ser Leu Ser Leu Val Phe Asp Ala Ser Ala Pro Ala His Cys
65                  70                  75                  80  
Gly Val Arg Val Gly Leu Ser Ala Gln Pro Cys Pro Asn Lys Ser Ser
                85                  90                  95      
Lys Ala Leu Phe His Leu Gln Ser Leu Glu Ser Phe Val Ala Cys Val
            100                 105                 110         
Ile Glu His Leu Ser Ser Pro Gln Leu Phe Thr Leu Lys Phe Arg Lys
        115                 120                 125             


<210> 7026
<211> 2548
<212> PRT
<213> Homo sapiens

<400> 7026
Met Asn Ile Asn Asp Gly Gly Arg Arg Arg Phe Glu Asp Asn Glu His
 1               5                  10                  15      
Thr Leu Arg Ile Tyr Pro Gly Ala Ile Ser Glu Gly Thr Ile Tyr Cys
            20                  25                  30          
Pro Ile Pro Ala Arg Lys Asn Ser Thr Ala Ala Glu Val Ile Glu Ser
        35                  40                  45              
Leu Ile Asn Lys Leu His Leu Asp Lys Thr Lys Cys Tyr Val Leu Ala
    50                  55                  60                  
Glu Val Lys Glu Phe Gly Gly Glu Glu Trp Ile Leu Asn Pro Thr Asp
65                  70                  75                  80  
Cys Pro Val Gln Gln Met Met Leu Trp Pro Arg Met Ala Leu Glu Asn
                85                  90                  95      
Arg Leu Ser Gly Glu Asp Tyr Arg Phe Leu Leu Arg Glu Lys Asn Leu
            100                 105                 110         
Asp Gly Ser Ile His Tyr Gly Ser Leu Gln Ser Trp Leu Arg Val Thr
        115                 120                 125             
Glu Glu Arg Arg Arg Met Met Glu Arg Gly Phe Leu Pro Gln Pro Gln
    130                 135                 140                 
Gln Lys Asp Phe Asp Asp Leu Cys Ser Leu Pro Asp Leu Asn Glu Lys
145                 150                 155                 160 
Thr Leu Leu Glu Asn Leu Arg Asp Arg Phe Lys His Glu Lys Ile Tyr
                165                 170                 175     
Thr Tyr Val Gly Ser Ile Leu Ile Val Ile Asn Pro Phe Lys Phe Leu
            180                 185                 190         
Pro Ile Tyr Asn Pro Lys Tyr Val Lys Met Tyr Asp Asn His Gln Leu
        195                 200                 205             
Gly Lys Pro Glu Pro His Ile Tyr Ala Val Ala Asp Val Ala Tyr His
    210                 215                 220                 
Ala Met Leu Gln Arg Lys Lys Asn Gln Cys Ile Val Ile Ser Gly Glu
225                 230                 235                 240 
Ser Gly Ser Gly Lys Thr Gln Ser Thr Asn Phe Leu Ile His His Leu
                245                 250                 255     
Thr Ala Leu Ser Gln Lys Gly Phe Ala Ser Gly Val Glu Gln Ile Ile
            260                 265                 270         
Leu Gly Ala Gly Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Ala
        275                 280                 285             
His Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Ile Gln Val Asn Tyr
    290                 295                 300                 
Gln Glu Thr Gly Thr Val Leu Gly Ala Tyr Val Glu Lys Tyr Leu Leu
305                 310                 315                 320 
Glu Lys Ser Arg Leu Val Tyr Gln Glu His Asn Glu Arg Asn Tyr His
                325                 330                 335     
Val Phe Tyr Tyr Leu Leu Ala Gly Ala Ser Glu Asp Glu Arg Ser Ala
            340                 345                 350         
Phe His Leu Lys Gln Pro Glu Glu Tyr His Tyr Leu Asn Gln Ile Thr
        355                 360                 365             
Lys Lys Pro Leu Arg Gln Ser Trp Asp Asp Tyr Cys Tyr Asp Ser Glu
    370                 375                 380                 
Pro Asp Cys Phe Thr Val Glu Gly Glu Asp Leu Arg His Asp Phe Glu
385                 390                 395                 400 
Arg Leu Gln Leu Ala Met Glu Met Val Gly Phe Leu Pro Lys Thr Arg
                405                 410                 415     
Arg Gln Ile Phe Ser Leu Leu Ser Ala Ile Leu His Leu Gly Asn Ile
            420                 425                 430         
Cys Tyr Lys Lys Lys Thr Tyr Arg Asp Asp Ser Ile Asp Ile Cys Asn
        435                 440                 445             
Pro Glu Val Leu Pro Ile Val Ser Glu Leu Leu Glu Val Lys Glu Glu
    450                 455                 460                 
Met Leu Phe Glu Ala Leu Val Thr Arg Lys Thr Val Thr Val Gly Glu
465                 470                 475                 480 
Lys Leu Ile Leu Pro Tyr Lys Leu Ala Glu Ala Val Thr Val Arg Asn
                485                 490                 495     
Ser Met Ala Lys Ser Leu Tyr Ser Ala Leu Phe Asp Trp Ile Val Phe
            500                 505                 510         
Arg Ile Asn His Ala Leu Leu Asn Ser Lys Asp Leu Glu His Asn Thr
        515                 520                 525             
Lys Thr Leu Ser Ile Gly Val Leu Asp Ile Phe Gly Phe Glu Asp Tyr
    530                 535                 540                 
Glu Asn Asn Ser Phe Glu Gln Phe Cys Ile Asn Phe Ala Asn Glu Arg
545                 550                 555                 560 
Leu Gln His Tyr Phe Asn Gln His Ile Phe Lys Leu Glu Gln Glu Glu
                565                 570                 575     
Tyr Arg Thr Glu Gly Ile Ser Trp His Asn Ile Asp Tyr Ile Asp Asn
            580                 585                 590         
Thr Cys Cys Ile Asn Leu Ile Ser Lys Lys Pro Thr Gly Leu Leu His
        595                 600                 605             
Leu Leu Asp Glu Glu Ser Asn Phe Pro Gln Ala Thr Asn Gln Thr Leu
    610                 615                 620                 
Leu Asp Lys Phe Lys His Gln His Glu Asp Asn Ser Tyr Ile Glu Phe
625                 630                 635                 640 
Pro Ala Val Met Glu Pro Ala Phe Ile Ile Lys His Tyr Ala Gly Lys
                645                 650                 655     
Val Lys Tyr Gly Val Lys Asp Phe Arg Glu Lys Asn Thr Asp His Met
            660                 665                 670         
Arg Pro Asp Ile Val Ala Leu Leu Arg Ser Ser Lys Asn Ala Phe Ile
        675                 680                 685             
Ser Gly Met Ile Gly Ile Asp Pro Val Ala Val Phe Arg Trp Ala Ile
    690                 695                 700                 
Leu Arg Ala Phe Phe Arg Ala Met Val Ala Phe Arg Glu Ala Gly Lys
705                 710                 715                 720 
Arg Asn Ile His Arg Lys Thr Gly His Asp Asp Thr Ala Pro Cys Ala
                725                 730                 735     
Ile Leu Lys Ser Met Asp Ser Phe Ser Phe Leu Gln His Pro Val His
            740                 745                 750         
Gln Arg Ser Leu Glu Ile Leu Gln Arg Cys Lys Glu Glu Lys Tyr Ser
        755                 760                 765             
Ile Thr Arg Lys Asn Pro Arg Thr Pro Leu Ser Asp Leu Gln Gly Met
    770                 775                 780                 
Asn Ala Leu Asn Glu Lys Asn Gln His Asp Thr Phe Asp Ile Ala Trp
785                 790                 795                 800 
Asn Gly Arg Thr Gly Ile Arg Gln Ser Arg Leu Ser Ser Gly Thr Ser
                805                 810                 815     
Leu Leu Asp Lys Asp Gly Ile Phe Ala Asn Ser Thr Ser Ser Lys Leu
            820                 825                 830         
Leu Glu Arg Ala His Gly Ile Leu Thr Arg Asn Lys Asn Phe Lys Ser
        835                 840                 845             
Lys Pro Ala Leu Pro Lys His Leu Leu Glu Val Asn Ser Leu Lys His
    850                 855                 860                 
Leu Thr Arg Leu Thr Leu Gln Asp Arg Ile Thr Lys Ser Leu Leu His
865                 870                 875                 880 
Leu His Lys Lys Lys Lys Pro Pro Ser Ile Ser Ala Gln Phe Gln Ala
                885                 890                 895     
Ser Leu Ser Lys Leu Met Glu Thr Leu Gly Gln Ala Glu Pro Tyr Phe
            900                 905                 910         
Val Lys Cys Ile Arg Ser Asn Ala Glu Lys Leu Pro Leu Arg Phe Ser
        915                 920                 925             
Asp Val Leu Val Leu Arg Gln Leu Arg Tyr Thr Gly Met Leu Glu Thr
    930                 935                 940                 
Val Gln Ile Arg Gln Ser Gly Tyr Ser Ser Lys Tyr Ser Phe Gln Asp
945                 950                 955                 960 
Phe Val Ser His Phe His Val Leu Leu Pro Arg Asn Ile Ile Pro Ser
                965                 970                 975     
Lys Phe Asn Ile Gln Asp Phe Phe Arg Lys Ile Asn Leu Asn Pro Asp
            980                 985                 990         
Asn Tyr Gln Val Gly Lys Thr Met Val Phe Leu Lys Glu Gln Glu Arg
        995                 1000                1005            
Gln His Leu Gln Asp Leu Leu His Gln Glu Val Leu Arg Arg Ile Ile
    1010                1015                1020                
Leu Leu Gln Arg Trp Phe Arg Val Leu Leu Cys Arg Gln His Phe Leu
1025                1030                1035                1040
His Leu Arg Gln Ala Ser Val Ile Ile Gln Arg Phe Trp Arg Asn Tyr
                1045                1050                1055    
Leu Asn Gln Lys Gln Val Arg Asp Ala Ala Val Gln Lys Asp Ala Phe
            1060                1065                1070        
Val Met Ala Ser Ala Ala Ala Leu Leu Gln Ala Ser Trp Arg Ala His
        1075                1080                1085            
Leu Glu Arg Gln Arg Tyr Leu Glu Leu Arg Ala Ala Ala Ile Val Ile
    1090                1095                1100                
Gln Gln Lys Trp Arg Asp Tyr Tyr Arg Arg Arg His Met Ala Ala Ile
1105                1110                1115                1120
Cys Ile Gln Ala Arg Trp Lys Ala Tyr Arg Glu Ser Lys Arg Tyr Gln
                1125                1130                1135    
Glu Gln Arg Lys Lys Ile Ile Leu Leu Gln Ser Thr Cys Arg Gly Phe
            1140                1145                1150        
Arg Ala Arg Gln Arg Phe Lys Ala Leu Lys Glu Gln Arg Leu Arg Glu
        1155                1160                1165            
Thr Lys Pro Glu Val Gly Leu Val Asn Ile Lys Gly Tyr Gly Ser Leu
    1170                1175                1180                
Glu Ile Gln Gly Ser Asp Pro Ser Glu Trp Glu Asp Cys Ser Phe Asp
1185                1190                1195                1200
Asn Arg Ile Lys Ala Ile Glu Glu Cys Lys Ser Val Ile Glu Ser Asn
                1205                1210                1215    
Arg Ile Ser Arg Glu Ser Ser Val Asp Cys Leu Lys Glu Ser Pro Asn
            1220                1225                1230        
Lys Gln Gln Glu Arg Ala Gln Ser Gln Ser Gly Val Asp Leu Gln Glu
        1235                1240                1245            
Asp Val Leu Val Arg Glu Arg Pro Arg Ser Leu Glu Asp Leu His Gln
    1250                1255                1260                
Lys Lys Val Gly Arg Ala Lys Arg Glu Ser Arg Arg Met Arg Glu Leu
1265                1270                1275                1280
Glu Gln Ala Ile Phe Ser Leu Glu Leu Leu Lys Val Arg Ser Leu Gly
                1285                1290                1295    
Gly Ile Ser Pro Ser Glu Asp Arg Arg Trp Ser Thr Glu Leu Val Pro
            1300                1305                1310        
Glu Gly Leu Gln Ser Pro Arg Gly Thr Pro Asp Ser Glu Ser Ser Gln
        1315                1320                1325            
Gly Ser Leu Glu Leu Leu Ser Tyr Glu Glu Ser Gln Lys Ser Lys Leu
    1330                1335                1340                
Glu Ser Val Ile Ser Asp Glu Gly Asp Leu Gln Phe Pro Ser Pro Lys
1345                1350                1355                1360
Ile Ser Ser Ser Pro Lys Phe Asp Ser Arg Asp Asn Ala Leu Ser Ala
                1365                1370                1375    
Ser Asn Glu Thr Ser Ser Ala Glu His Leu Lys Asp Gly Thr Met Lys
            1380                1385                1390        
Glu Met Val Val Cys Ser Ser Glu Ser Ile Thr Cys Lys Pro Gln Leu
        1395                1400                1405            
Lys Asp Ser Phe Ile Ser Asn Ser Leu Pro Thr Phe Phe Tyr Ile Pro
    1410                1415                1420                
Gln Gln Asp Pro Leu Lys Thr Asn Ser Gln Leu Asp Thr Ser Ile Gln
1425                1430                1435                1440
Arg Asn Lys Leu Leu Glu Asn Glu Asp Thr Ala Gly Glu Ala Leu Thr
                1445                1450                1455    
Leu Asp Ile Asn Arg Glu Thr Arg Arg Tyr His Cys Ser Gly Lys Asp
            1460                1465                1470        
Gln Ile Val Pro Ser Leu Asn Thr Glu Ser Ser Asn Pro Val Leu Lys
        1475                1480                1485            
Lys Leu Glu Lys Leu Asn Thr Glu Lys Glu Glu Arg Gln Lys Gln Leu
    1490                1495                1500                
Gln Gln Gln Asn Glu Lys Glu Met Met Glu Gln Ile Arg Gln Gln Thr
1505                1510                1515                1520
Asp Ile Leu Glu Lys Glu Arg Lys Ala Phe Lys Thr Ile Glu Lys Pro
                1525                1530                1535    
Arg Ile Gly Glu Cys Leu Val Ala Pro Ser Ser Tyr Gln Ser Lys Gln
            1540                1545                1550        
Arg Val Glu Arg Pro Ser Ser Leu Leu Ser Leu Asn Thr Ser Asn Lys
        1555                1560                1565            
Gly Glu Leu Asn Val Leu Gly Ser Leu Ser Leu Lys Asp Ala Ala Leu
    1570                1575                1580                
Ala Gln Lys Asp Ser Ser Ser Ala His Leu Pro Pro Lys Asp Arg Pro
1585                1590                1595                1600
Val Thr Val Phe Phe Glu Arg Lys Gly Ser Pro Cys Gln Ser Ser Thr
                1605                1610                1615    
Val Lys Glu Leu Ser Lys Thr Asp Arg Met Gly Thr Gln Leu Asn Val
            1620                1625                1630        
Ala Cys Lys Leu Ser Asn Asn Arg Ile Ser Lys Arg Glu His Phe Arg
        1635                1640                1645            
Pro Thr Gln Ser Tyr Ser His Asn Ser Asp Asp Leu Ser Arg Glu Gly
    1650                1655                1660                
Asn Ala Arg Pro Ile Phe Phe Thr Pro Lys Asp Asn Met Ser Ile Pro
1665                1670                1675                1680
Leu Val Ser Lys Glu Ala Leu Asn Ser Lys Asn Pro Gln Leu His Lys
                1685                1690                1695    
Glu Asp Glu Pro Ala Trp Lys Pro Val Lys Leu Ala Gly Pro Gly Gln
            1700                1705                1710        
Arg Glu Thr Ser Gln Arg Phe Ser Ser Val Asp Glu Gln Ala Lys Leu
        1715                1720                1725            
His Lys Thr Met Ser Gln Gly Glu Ile Thr Lys Leu Ala Val Arg Gln
    1730                1735                1740                
Lys Ala Ser Asp Ser Asp Ile Arg Pro Gln Arg Ala Lys Met Arg Phe
1745                1750                1755                1760
Trp Ala Lys Gly Lys Gln Gly Glu Lys Lys Thr Thr Arg Val Lys Pro
                1765                1770                1775    
Thr Thr Gln Ser Glu Val Ser Pro Leu Phe Ala Gly Thr Asp Val Ile
            1780                1785                1790        
Pro Ala His Gln Phe Pro Asp Glu Leu Ala Ala Tyr His Pro Thr Pro
        1795                1800                1805            
Pro Leu Ser Pro Glu Leu Pro Gly Ser Cys Arg Lys Glu Phe Lys Glu
    1810                1815                1820                
Asn Lys Glu Pro Ser Pro Lys Ala Lys Arg Lys Arg Ser Val Lys Ile
1825                1830                1835                1840
Ser Asn Val Ala Leu Asp Ser Met His Trp Gln Asn Asp Ser Val Gln
                1845                1850                1855    
Ile Ile Ala Ser Val Ser Asp Leu Lys Ser Met Asp Glu Phe Leu Leu
            1860                1865                1870        
Lys Lys Val Asn Asp Leu Asp Asn Glu Asp Ser Lys Lys Asp Thr Leu
        1875                1880                1885            
Val Asp Val Val Phe Lys Lys Ala Leu Lys Glu Phe Arg Gln Asn Ile
    1890                1895                1900                
Phe Ser Phe Tyr Ser Ser Ala Leu Ala Met Asp Asp Gly Lys Ser Ile
1905                1910                1915                1920
Arg Tyr Lys Asp Leu Tyr Ala Leu Phe Glu Gln Ile Leu Glu Lys Thr
                1925                1930                1935    
Met Arg Leu Glu Gln Arg Asp Ser Leu Gly Glu Ser Pro Val Arg Val
            1940                1945                1950        
Trp Val Asn Thr Phe Lys Val Phe Leu Asp Glu Tyr Met Asn Glu Phe
        1955                1960                1965            
Lys Thr Ser Asp Cys Thr Ala Thr Lys Val Pro Lys Thr Glu Arg Lys
    1970                1975                1980                
Lys Arg Arg Lys Lys Glu Thr Asp Leu Val Glu Glu His Asn Gly His
1985                1990                1995                2000
Ile Phe Lys Ala Thr Gln Tyr Ser Ile Pro Thr Tyr Cys Glu Tyr Cys
                2005                2010                2015    
Ser Ser Leu Ile Trp Ile Met Asp Arg Ala Ser Val Cys Lys Leu Cys
            2020                2025                2030        
Lys Tyr Ala Cys His Lys Lys Cys Cys Leu Lys Thr Thr Ala Lys Cys
        2035                2040                2045            
Ser Lys Lys Tyr Asp Pro Glu Leu Ser Ser Arg Gln Phe Gly Val Glu
    2050                2055                2060                
Leu Ser Arg Leu Thr Ser Glu Asp Arg Thr Val Pro Leu Val Val Glu
2065                2070                2075                2080
Lys Leu Ile Asn Tyr Ile Glu Met His Gly Leu Tyr Thr Glu Gly Ile
                2085                2090                2095    
Tyr Arg Lys Ser Gly Ser Thr Asn Lys Ile Lys Glu Leu Arg Gln Gly
            2100                2105                2110        
Leu Asp Thr Asp Ala Glu Ser Val Asn Leu Asp Asp Tyr Asn Ile His
        2115                2120                2125            
Val Ile Ala Ser Val Phe Lys Gln Trp Leu Arg Asp Leu Pro Asn Pro
    2130                2135                2140                
Leu Met Thr Phe Glu Leu Tyr Glu Glu Phe Leu Arg Ala Met Gly Leu
2145                2150                2155                2160
Gln Glu Arg Lys Glu Thr Ile Arg Gly Val Tyr Ser Val Ile Asp Gln
                2165                2170                2175    
Leu Ser Arg Thr His Leu Asn Thr Leu Glu Arg Leu Ile Phe His Leu
            2180                2185                2190        
Val Arg Ile Ala Leu Gln Glu Asp Thr Asn Arg Met Ser Ala Asn Ala
        2195                2200                2205            
Leu Ala Ile Val Phe Ala Pro Cys Ile Leu Arg Cys Pro Asp Thr Thr
    2210                2215                2220                
Asp Pro Leu Gln Ser Val Gln Asp Ile Ser Lys Thr Thr Thr Cys Val
2225                2230                2235                2240
Glu Leu Ile Val Val Glu Gln Met Asn Lys Tyr Lys Ala Arg Leu Lys
                2245                2250                2255    
Asp Ile Ser Ser Leu Glu Phe Ala Glu Asn Lys Ala Lys Thr Arg Leu
            2260                2265                2270        
Ser Leu Ile Arg Arg Ser Met Gly Lys Gly Arg Ile Arg Arg Gly Asn
        2275                2280                2285            
Tyr Pro Gly Pro Ser Ser Pro Val Val Val Arg Leu Pro Ser Val Ser
    2290                2295                2300                
Asp Val Ser Glu Glu Thr Leu Thr Ser Glu Ala Ala Met Glu Thr Asp
2305                2310                2315                2320
Ile Thr Glu Gln Gln Gln Ala Ala Met Gln Gln Glu Glu Arg Val Leu
                2325                2330                2335    
Thr Glu Gln Ile Glu Asn Leu Gln Lys Glu Lys Glu Glu Leu Thr Phe
            2340                2345                2350        
Glu Met Leu Val Leu Glu Pro Arg Ala Ser Asp Asp Glu Thr Leu Glu
        2355                2360                2365            
Ser Glu Ala Ser Ile Gly Thr Ala Asp Ser Ser Glu Asn Leu Asn Met
    2370                2375                2380                
Glu Ser Glu Tyr Ala Ile Ser Glu Lys Ser Glu Arg Ser Leu Ala Leu
2385                2390                2395                2400
Ser Ser Leu Lys Thr Ala Gly Lys Ser Glu Pro Ser Ser Lys Leu Arg
                2405                2410                2415    
Lys Gln Leu Lys Lys Gln Gln Asp Ser Leu Asp Val Val Asp Ser Ser
            2420                2425                2430        
Val Ser Ser Leu Cys Leu Ser Asn Thr Ala Ser Ser His Gly Thr Arg
        2435                2440                2445            
Lys Leu Phe Gln Ile Tyr Ser Lys Ser Pro Phe Tyr Arg Ala Ala Ser
    2450                2455                2460                
Gly Asn Glu Ala Leu Gly Met Glu Gly Pro Leu Gly Gln Thr Lys Phe
2465                2470                2475                2480
Leu Glu Asp Lys Pro Gln Phe Ile Ser Arg Gly Thr Phe Asn Pro Glu
                2485                2490                2495    
Lys Gly Lys Gln Lys Leu Lys Asn Val Lys Asn Ser Pro Gln Lys Thr
            2500                2505                2510        
Lys Glu Thr Pro Glu Gly Thr Val Met Ser Gly Arg Arg Lys Thr Val
        2515                2520                2525            
Asp Pro Asp Cys Thr Ser Asn Gln Gln Leu Ala Leu Phe Gly Asn Asn
    2530                2535                2540                
Glu Phe Met Val
2545            


<210> 7027
<211> 1397
<212> PRT
<213> Homo sapiens

<400> 7027
Ser Val Asp Cys Leu Lys Glu Ser Pro Asn Lys Gln Gln Glu Arg Ala
 1               5                  10                  15      
Gln Ser Gln Ser Gly Val Asp Leu Gln Glu Asp Val Leu Val Arg Glu
            20                  25                  30          
Arg Pro Arg Ser Leu Glu Asp Leu His Gln Lys Lys Val Gly Arg Ala
        35                  40                  45              
Lys Arg Glu Ser Arg Arg Met Arg Glu Leu Glu Gln Ala Ile Phe Ser
    50                  55                  60                  
Leu Glu Leu Leu Lys Val Arg Ser Leu Gly Gly Ile Ser Pro Ser Glu
65                  70                  75                  80  
Asp Arg Arg Trp Ser Thr Glu Leu Val Pro Glu Gly Leu Gln Ser Pro
                85                  90                  95      
Arg Gly Thr Pro Asp Ser Glu Ser Ser Gln Gly Ser Leu Glu Leu Leu
            100                 105                 110         
Ser Tyr Glu Glu Ser Gln Lys Ser Lys Leu Glu Ser Val Ile Ser Asp
        115                 120                 125             
Glu Gly Asp Leu Gln Phe Pro Ser Pro Lys Ile Ser Ser Ser Pro Lys
    130                 135                 140                 
Phe Asp Ser Arg Asp Asn Ala Leu Ser Ala Ser Asn Glu Thr Ser Ser
145                 150                 155                 160 
Ala Glu His Leu Lys Asp Gly Thr Met Lys Glu Met Val Val Cys Ser
                165                 170                 175     
Ser Glu Ser Ile Thr Cys Lys Pro Gln Leu Lys Asp Ser Phe Ile Ser
            180                 185                 190         
Asn Ser Leu Pro Thr Phe Phe Tyr Ile Pro Gln Gln Asp Pro Leu Lys
        195                 200                 205             
Thr Asn Ser Gln Leu Asp Thr Ser Ile Gln Arg Asn Lys Leu Leu Glu
    210                 215                 220                 
Asn Glu Asp Thr Ala Gly Glu Ala Leu Thr Leu Asp Ile Asn Arg Glu
225                 230                 235                 240 
Thr Arg Arg Tyr His Cys Ser Gly Lys Asp Gln Ile Val Pro Ser Leu
                245                 250                 255     
Asn Thr Glu Ser Ser Asn Pro Val Leu Lys Lys Leu Glu Lys Leu Asn
            260                 265                 270         
Thr Glu Lys Glu Glu Arg Gln Lys Gln Leu Gln Gln Gln Asn Glu Lys
        275                 280                 285             
Glu Met Met Glu Gln Ile Arg Gln Gln Thr Asp Ile Leu Glu Lys Glu
    290                 295                 300                 
Arg Lys Ala Phe Lys Thr Ile Glu Lys Pro Arg Ile Gly Glu Cys Leu
305                 310                 315                 320 
Val Ala Pro Ser Ser Tyr Gln Ser Lys Gln Arg Val Glu Arg Pro Ser
                325                 330                 335     
Ser Leu Leu Ser Leu Asn Thr Ser Asn Lys Gly Glu Leu Asn Val Leu
            340                 345                 350         
Gly Ser Leu Ser Leu Lys Asp Ala Ala Leu Ala Gln Lys Asp Ser Ser
        355                 360                 365             
Ser Ala His Leu Pro Pro Lys Asp Arg Pro Val Thr Val Phe Phe Glu
    370                 375                 380                 
Arg Lys Gly Ser Pro Cys Gln Ser Ser Thr Val Lys Glu Leu Ser Lys
385                 390                 395                 400 
Thr Asp Arg Met Gly Thr Gln Leu Asn Val Ala Cys Lys Leu Ser Asn
                405                 410                 415     
Asn Arg Ile Ser Lys Arg Glu His Phe Arg Pro Thr Gln Ser Tyr Ser
            420                 425                 430         
His Asn Ser Asp Asp Leu Ser Arg Glu Gly Asn Ala Arg Pro Ile Phe
        435                 440                 445             
Phe Thr Pro Lys Asp Asn Met Ser Ile Pro Leu Val Ser Lys Glu Ala
    450                 455                 460                 
Leu Asn Ser Lys Asn Pro Gln Leu His Lys Glu Asp Glu Pro Ala Trp
465                 470                 475                 480 
Lys Pro Val Lys Leu Ala Gly Pro Gly Gln Arg Glu Val Ala Arg Pro
                485                 490                 495     
Ala His Lys Lys Lys Ala Arg Met Ala Arg Thr Arg Ser Asp Phe Leu
            500                 505                 510         
Thr Arg Gly Thr Phe Ala Asp Gly Glu Gly Asp Thr Glu Glu Asp Asp
        515                 520                 525             
Tyr Asp Asp Ile Ile Glu Pro Leu Leu Ser Leu Asp Gln Ala Ser His
    530                 535                 540                 
Cys Glu Leu Gly Pro Ala Pro Ser Leu Gly Gln Ala Ser His Ser Asp
545                 550                 555                 560 
Ser Glu Met Thr Ser Gln Arg Phe Ser Ser Val Asp Glu Gln Ala Lys
                565                 570                 575     
Leu His Lys Thr Met Ser Gln Gly Glu Ile Thr Lys Leu Ala Val Arg
            580                 585                 590         
Gln Lys Ala Ser Asp Ser Asp Ile Arg Pro Gln Arg Ala Lys Met Arg
        595                 600                 605             
Phe Trp Ala Lys Gly Lys Gln Gly Glu Lys Lys Thr Thr Arg Val Lys
    610                 615                 620                 
Pro Thr Thr Gln Ser Glu Val Ser Pro Leu Phe Ala Gly Thr Asp Val
625                 630                 635                 640 
Ile Pro Ala His Gln Phe Pro Asp Glu Leu Ala Ala Tyr His Pro Thr
                645                 650                 655     
Pro Pro Leu Ser Pro Glu Leu Pro Gly Ser Cys Arg Lys Glu Phe Lys
            660                 665                 670         
Glu Asn Lys Glu Pro Ser Pro Lys Ala Lys Arg Lys Arg Ser Val Lys
        675                 680                 685             
Ile Ser Asn Val Ala Leu Asp Ser Met His Trp Gln Asn Asp Ser Val
    690                 695                 700                 
Gln Ile Ile Ala Ser Val Ser Asp Leu Lys Ser Met Asp Glu Phe Leu
705                 710                 715                 720 
Leu Lys Lys Val Asn Asp Leu Asp Asn Glu Asp Ser Lys Lys Asp Thr
                725                 730                 735     
Leu Val Asp Val Val Phe Lys Lys Ala Leu Lys Glu Phe Arg Gln Asn
            740                 745                 750         
Ile Phe Ser Phe Tyr Ser Ser Ala Leu Ala Met Asp Asp Gly Lys Ser
        755                 760                 765             
Ile Arg Tyr Lys Asp Leu Tyr Ala Leu Phe Glu Gln Ile Leu Glu Lys
    770                 775                 780                 
Thr Met Arg Leu Glu Gln Arg Asp Ser Leu Gly Glu Ser Pro Val Arg
785                 790                 795                 800 
Val Trp Val Asn Thr Phe Lys Val Phe Leu Asp Glu Tyr Met Asn Glu
                805                 810                 815     
Phe Lys Thr Ser Asp Cys Thr Ala Thr Lys Val Pro Lys Thr Glu Arg
            820                 825                 830         
Lys Lys Arg Arg Lys Lys Glu Thr Asp Leu Val Glu Glu His Asn Gly
        835                 840                 845             
His Ile Phe Lys Ala Thr Gln Tyr Ser Ile Pro Thr Tyr Cys Glu Tyr
    850                 855                 860                 
Cys Ser Ser Leu Ile Trp Ile Met Asp Arg Ala Ser Val Cys Lys Leu
865                 870                 875                 880 
Cys Lys Tyr Ala Cys His Lys Lys Cys Cys Leu Lys Thr Thr Ala Lys
                885                 890                 895     
Cys Ser Lys Lys Tyr Asp Pro Glu Leu Ser Ser Arg Gln Phe Gly Val
            900                 905                 910         
Glu Leu Ser Arg Leu Thr Ser Glu Asp Arg Thr Val Pro Leu Val Val
        915                 920                 925             
Glu Lys Leu Ile Asn Tyr Ile Glu Met His Gly Leu Tyr Thr Glu Gly
    930                 935                 940                 
Ile Tyr Arg Lys Ser Gly Ser Thr Asn Lys Ile Lys Glu Leu Arg Gln
945                 950                 955                 960 
Gly Leu Asp Thr Asp Ala Glu Ser Val Asn Leu Asp Asp Tyr Asn Ile
                965                 970                 975     
His Val Ile Ala Ser Val Phe Lys Gln Trp Leu Arg Asp Leu Pro Asn
            980                 985                 990         
Pro Leu Met Thr Phe Glu Leu Tyr Glu Glu Phe Leu Arg Ala Met Gly
        995                 1000                1005            
Leu Gln Glu Arg Lys Glu Thr Ile Arg Gly Val Tyr Ser Val Ile Asp
    1010                1015                1020                
Gln Leu Ser Arg Thr His Leu Asn Thr Leu Glu Arg Leu Ile Phe His
1025                1030                1035                1040
Leu Val Arg Ile Ala Leu Gln Glu Asp Thr Asn Arg Met Ser Ala Asn
                1045                1050                1055    
Ala Leu Ala Ile Val Phe Ala Pro Cys Ile Leu Arg Cys Pro Asp Thr
            1060                1065                1070        
Thr Asp Pro Leu Gln Ser Val Gln Asp Ile Ser Lys Thr Thr Thr Cys
        1075                1080                1085            
Val Glu Leu Ile Val Val Glu Gln Met Asn Lys Tyr Lys Ala Arg Leu
    1090                1095                1100                
Lys Asp Ile Ser Ser Leu Glu Phe Ala Glu Asn Lys Ala Lys Thr Arg
1105                1110                1115                1120
Leu Ser Leu Ile Arg Arg Ser Met Gly Lys Gly Arg Ile Arg Arg Gly
                1125                1130                1135    
Asn Tyr Pro Gly Pro Ser Ser Pro Val Val Val Arg Leu Pro Ser Val
            1140                1145                1150        
Ser Asp Val Ser Glu Glu Thr Leu Thr Ser Glu Ala Ala Met Glu Thr
        1155                1160                1165            
Asp Ile Thr Glu Gln Gln Gln Ala Ala Met Gln Gln Glu Glu Arg Val
    1170                1175                1180                
Leu Thr Glu Gln Ile Glu Asn Leu Gln Lys Glu Lys Glu Glu Leu Thr
1185                1190                1195                1200
Phe Glu Met Leu Val Leu Glu Pro Arg Ala Ser Asp Asp Glu Thr Leu
                1205                1210                1215    
Glu Ser Glu Ala Ser Ile Gly Thr Ala Asp Ser Ser Glu Asn Leu Asn
            1220                1225                1230        
Met Glu Ser Glu Tyr Ala Ile Ser Glu Lys Ser Glu Arg Ser Leu Ala
        1235                1240                1245            
Leu Ser Ser Leu Lys Thr Ala Gly Lys Ser Glu Pro Ser Ser Lys Leu
    1250                1255                1260                
Arg Lys Gln Leu Lys Lys Gln Gln Asp Ser Leu Asp Val Val Asp Ser
1265                1270                1275                1280
Ser Val Ser Ser Leu Cys Leu Ser Asn Thr Ala Ser Ser His Gly Thr
                1285                1290                1295    
Arg Lys Leu Phe Gln Ile Tyr Ser Lys Ser Pro Phe Tyr Arg Ala Ala
            1300                1305                1310        
Ser Gly Asn Glu Ala Leu Gly Met Glu Gly Pro Leu Gly Gln Thr Lys
        1315                1320                1325            
Phe Leu Glu Asp Lys Pro Gln Phe Ile Ser Arg Gly Thr Phe Asn Pro
    1330                1335                1340                
Glu Lys Gly Lys Gln Lys Leu Lys Asn Val Lys Asn Ser Pro Gln Lys
1345                1350                1355                1360
Thr Lys Glu Thr Pro Glu Gly Thr Val Met Ser Gly Arg Arg Lys Thr
                1365                1370                1375    
Val Asp Pro Asp Cys Thr Ser Asn Gln Gln Leu Ala Leu Phe Gly Asn
            1380                1385                1390        
Asn Glu Phe Met Val
        1395        


<210> 7028
<211> 1324
<212> PRT
<213> Homo sapiens

<400> 7028
Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp
 1               5                  10                  15      
Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg
            20                  25                  30          
Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe
        35                  40                  45              
Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Lys Ala Thr Ala Gly Gly
    50                  55                  60                  
Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys
65                  70                  75                  80  
Asn Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp
                85                  90                  95      
Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Pro Lys His Lys Tyr Leu
            100                 105                 110         
Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn
        115                 120                 125             
Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser
    130                 135                 140                 
Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala
145                 150                 155                 160 
Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Val Gly Gly Ser Ala Gly
                165                 170                 175     
Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala
            180                 185                 190         
Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly
        195                 200                 205             
Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg
    210                 215                 220                 
Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu
225                 230                 235                 240 
Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe
                245                 250                 255     
Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met
            260                 265                 270         
Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu
        275                 280                 285             
Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser
    290                 295                 300                 
Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro
305                 310                 315                 320 
Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr
                325                 330                 335     
Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro
            340                 345                 350         
Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp
        355                 360                 365             
Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser
    370                 375                 380                 
Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser
385                 390                 395                 400 
Arg Ser His Thr Leu Ile Gly Gly Cys Arg Ala Ala Gly Thr Lys Trp
                405                 410                 415     
His Cys Phe Pro Ala Gly Gly Gly Leu Gln His Ser Arg Ser Met Ser
            420                 425                 430         
Met Pro Val Glu His Leu Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu
        435                 440                 445             
Ser Ser Ser Ser Asp His Gly Trp Gly Ser Tyr Pro Pro Pro Pro Gly
    450                 455                 460                 
Pro His Pro Leu Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg
465                 470                 475                 480 
Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly
                485                 490                 495     
Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala
            500                 505                 510         
Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro
        515                 520                 525             
Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr
    530                 535                 540                 
Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser
545                 550                 555                 560 
Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr
                565                 570                 575     
Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser
            580                 585                 590         
Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser
        595                 600                 605             
Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala
    610                 615                 620                 
Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His
625                 630                 635                 640 
Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met
                645                 650                 655     
Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser
            660                 665                 670         
Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln
        675                 680                 685             
Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Phe
    690                 695                 700                 
Ala Gly Pro Ala Gly Pro Ala Pro Thr Phe Ala Ala Gly Arg Thr Phe
705                 710                 715                 720 
Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser
                725                 730                 735     
Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser
            740                 745                 750         
Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn
        755                 760                 765             
Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe
    770                 775                 780                 
Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly
785                 790                 795                 800 
Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys
                805                 810                 815     
Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg
            820                 825                 830         
Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Thr
        835                 840                 845             
Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro
    850                 855                 860                 
Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe
865                 870                 875                 880 
Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu
                885                 890                 895     
Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu
            900                 905                 910         
Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly
        915                 920                 925             
Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser
    930                 935                 940                 
Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Leu Ser Leu Gly Ser
945                 950                 955                 960 
Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser
                965                 970                 975     
Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly
            980                 985                 990         
Ala Pro Ser Gly His Pro Val Gly Ser Leu Asp Gly Leu Leu Ser Pro
        995                 1000                1005            
Glu Ala Ser Ser Pro Tyr Pro Pro Leu Pro Pro Arg Pro Ser Ala Ser
    1010                1015                1020                
Pro Ser Ser Ser Leu Gln Pro Pro Pro Pro Pro Pro Ala Pro Gly Glu
1025                1030                1035                1040
Leu Tyr Arg Leu Pro Pro Ala Ser Ala Val Ala Thr Ala Gln Gly Pro
                1045                1050                1055    
Gly Ala Ala Ser Ser Leu Ser Ser Asp Thr Gly Asp Asn Gly Asp Tyr
            1060                1065                1070        
Thr Glu Met Ala Phe Gly Val Ala Ala Thr Pro Pro Gln Pro Ile Ala
        1075                1080                1085            
Ala Pro Pro Lys Pro Glu Ala Ala Arg Val Ala Ser Pro Thr Ser Gly
    1090                1095                1100                
Val Lys Arg Leu Ser Leu Met Glu Gln Val Ser Gly Val Glu Ala Phe
1105                1110                1115                1120
Leu Gln Ala Ser Gln Pro Pro Asp Pro His Arg Gly Ala Lys Val Ile
                1125                1130                1135    
Arg Ala Asp Pro Gln Gly Gly Arg Arg Arg His Ser Ser Glu Thr Phe
            1140                1145                1150        
Ser Ser Thr Thr Thr Val Thr Pro Val Ser Pro Ser Phe Ala His Asn
        1155                1160                1165            
Pro Lys Arg His Asn Ser Ala Ser Val Glu Asn Val Ser Leu Arg Lys
    1170                1175                1180                
Ser Ser Glu Gly Gly Val Gly Val Gly Pro Gly Gly Gly Asp Glu Pro
1185                1190                1195                1200
Pro Thr Ser Pro Arg Gln Leu Gln Pro Ala Pro Pro Leu Ala Pro Gln
                1205                1210                1215    
Gly Arg Pro Trp Thr Pro Gly Gln Pro Gly Gly Leu Val Gly Cys Pro
            1220                1225                1230        
Gly Ser Gly Gly Ser Pro Met Arg Arg Glu Thr Ser Ala Gly Phe Gln
        1235                1240                1245            
Asn Gly Leu Lys Tyr Ile Ala Ile Asp Val Arg Glu Glu Pro Gly Leu
    1250                1255                1260                
Pro Pro Gln Pro Gln Pro Pro Pro Pro Pro Leu Pro Gln Pro Gly Asp
1265                1270                1275                1280
Lys Ser Ser Trp Gly Arg Thr Arg Ser Leu Gly Gly Leu Ile Ser Ala
                1285                1290                1295    
Val Gly Val Gly Ser Thr Arg Gly Gly Cys Gly Gly Pro Gly Pro Gly
            1300                1305                1310        
Ala Pro Ala Pro Cys Pro Thr Thr Tyr Ala Gln His
        1315                1320                


<210> 7029
<211> 1338
<212> PRT
<213> Homo sapiens

<400> 7029
Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp
 1               5                  10                  15      
Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg
            20                  25                  30          
Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe
        35                  40                  45              
Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Glu Ala Thr Ala Gly Gly
    50                  55                  60                  
Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys
65                  70                  75                  80  
Lys Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp
                85                  90                  95      
Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Ala Lys His Lys Tyr Leu
            100                 105                 110         
Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn
        115                 120                 125             
Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser
    130                 135                 140                 
Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala
145                 150                 155                 160 
Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Leu Gly Gly Ser Ala Gly
                165                 170                 175     
Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala
            180                 185                 190         
Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly
        195                 200                 205             
Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg
    210                 215                 220                 
Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu
225                 230                 235                 240 
Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe
                245                 250                 255     
Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met
            260                 265                 270         
Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu
        275                 280                 285             
Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser
    290                 295                 300                 
Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro
305                 310                 315                 320 
Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr
                325                 330                 335     
Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro
            340                 345                 350         
Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp
        355                 360                 365             
Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser
    370                 375                 380                 
Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser
385                 390                 395                 400 
Arg Ser His Thr Leu Ser Gly Gly Cys Gly Gly Arg Gly Ser Lys Val
                405                 410                 415     
Ala Leu Leu Pro Ala Gly Gly Ala Leu Gln His Ser Arg Ser Met Ser
            420                 425                 430         
Met Pro Val Ala His Ser Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu
        435                 440                 445             
Ser Ser Ser Ser Gly His Gly Ser Gly Ser Tyr Pro Pro Pro Pro Gly
    450                 455                 460                 
Pro His Pro Pro Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg
465                 470                 475                 480 
Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly
                485                 490                 495     
Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala
            500                 505                 510         
Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro
        515                 520                 525             
Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr
    530                 535                 540                 
Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser
545                 550                 555                 560 
Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr
                565                 570                 575     
Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser
            580                 585                 590         
Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser
        595                 600                 605             
Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala
    610                 615                 620                 
Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His
625                 630                 635                 640 
Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met
                645                 650                 655     
Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser
            660                 665                 670         
Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln
        675                 680                 685             
Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Ser
    690                 695                 700                 
Ala Gly Pro Ala Gly Pro Ala Pro Thr Ser Ala Ala Gly Arg Thr Phe
705                 710                 715                 720 
Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser
                725                 730                 735     
Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser
            740                 745                 750         
Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn
        755                 760                 765             
Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe
    770                 775                 780                 
Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly
785                 790                 795                 800 
Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys
                805                 810                 815     
Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg
            820                 825                 830         
Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Ser
        835                 840                 845             
Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro
    850                 855                 860                 
Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe
865                 870                 875                 880 
Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu
                885                 890                 895     
Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu
            900                 905                 910         
Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly
        915                 920                 925             
Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser
    930                 935                 940                 
Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Ser Ser Leu Gly Ser
945                 950                 955                 960 
Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser
                965                 970                 975     
Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly
            980                 985                 990         
Ala Pro Ser Gly His Pro Val Gly Ser Leu Asp Gly Leu Leu Ser Pro
        995                 1000                1005            
Glu Ala Ser Ser Pro Tyr Pro Pro Leu Pro Pro Arg Pro Ser Ala Ser
    1010                1015                1020                
Pro Ser Ser Ser Leu Gln Pro Pro Pro Pro Pro Pro Ala Pro Gly Glu
1025                1030                1035                1040
Leu Tyr Arg Leu Pro Pro Ala Ser Ala Val Ala Thr Ala Gln Gly Pro
                1045                1050                1055    
Gly Ala Ala Ser Ser Leu Ser Ser Asp Thr Gly Asp Asn Gly Asp Tyr
            1060                1065                1070        
Thr Glu Met Ala Phe Gly Val Ala Ala Thr Pro Pro Gln Pro Ile Ala
        1075                1080                1085            
Ala Pro Pro Lys Pro Glu Ala Ala Arg Val Ala Ser Pro Thr Ser Gly
    1090                1095                1100                
Val Lys Arg Leu Ser Leu Met Glu Gln Val Ser Gly Val Glu Ala Phe
1105                1110                1115                1120
Leu Gln Ala Ser Gln Pro Pro Asp Pro His Arg Gly Ala Lys Val Ile
                1125                1130                1135    
Arg Ala Asp Pro Gln Gly Gly Arg Arg Arg His Ser Ser Glu Thr Phe
            1140                1145                1150        
Ser Ser Thr Thr Thr Val Thr Pro Val Ser Pro Ser Phe Ala His Asn
        1155                1160                1165            
Pro Lys Arg His Asn Ser Ala Ser Val Glu Asn Val Ser Leu Arg Lys
    1170                1175                1180                
Ser Ser Glu Gly Gly Val Gly Val Gly Pro Gly Gly Gly Asp Glu Pro
1185                1190                1195                1200
Pro Thr Ser Pro Arg Gln Leu Gln Pro Ala Pro Pro Leu Ala Pro Gln
                1205                1210                1215    
Gly Arg Pro Trp Thr Pro Gly Gln Pro Gly Gly Leu Val Gly Cys Pro
            1220                1225                1230        
Gly Ser Gly Gly Ser Pro Met Arg Arg Glu Thr Ser Ala Gly Phe Gln
        1235                1240                1245            
Asn Gly Leu Asn Tyr Ile Ala Ile Asp Val Arg Glu Glu Pro Gly Leu
    1250                1255                1260                
Pro Pro Gln Pro Gln Pro Pro Pro Pro Pro Leu Pro Gln Pro Gly Asp
1265                1270                1275                1280
Lys Ser Ser Trp Gly Arg Thr Arg Ser Leu Gly Gly Leu Ile Ser Ala
                1285                1290                1295    
Val Gly Val Gly Ser Thr Gly Gly Gly Cys Gly Gly Pro Gly Pro Gly
            1300                1305                1310        
Ala Leu Pro Pro Ala Asn Thr Tyr Ala Ser Ile Asp Phe Leu Ser His
        1315                1320                1325            
His Leu Lys Glu Ala Thr Ile Val Lys Glu
    1330                1335            


<210> 7030
<211> 3957
<212> PRT
<213> Homo sapiens

<400> 7030
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe
 1               5                  10                  15      
Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn
            20                  25                  30          
Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val
        35                  40                  45              
Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly
    50                  55                  60                  
Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val
65                  70                  75                  80  
Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys
                85                  90                  95      
Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val
            100                 105                 110         
Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln
        115                 120                 125             
Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp
    130                 135                 140                 
Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr
145                 150                 155                 160 
Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn
                165                 170                 175     
Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg
            180                 185                 190         
Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala
        195                 200                 205             
Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met
    210                 215                 220                 
Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala
225                 230                 235                 240 
Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly
                245                 250                 255     
Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val
            260                 265                 270         
Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg
        275                 280                 285             
Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His
    290                 295                 300                 
Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu
305                 310                 315                 320 
Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu
                325                 330                 335     
His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu
            340                 345                 350         
Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala
        355                 360                 365             
Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu
    370                 375                 380                 
Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr
385                 390                 395                 400 
Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu
                405                 410                 415     
Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu
            420                 425                 430         
Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu
        435                 440                 445             
Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly
    450                 455                 460                 
Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val
465                 470                 475                 480 
Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu
                485                 490                 495     
Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile
            500                 505                 510         
Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr
        515                 520                 525             
Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp
    530                 535                 540                 
Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr
545                 550                 555                 560 
Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu
                565                 570                 575     
Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala
            580                 585                 590         
Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn
        595                 600                 605             
Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala
    610                 615                 620                 
Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn
625                 630                 635                 640 
Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn
                645                 650                 655     
Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu
            660                 665                 670         
Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile
        675                 680                 685             
His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln
    690                 695                 700                 
Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp
705                 710                 715                 720 
Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys
                725                 730                 735     
His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala
            740                 745                 750         
Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala
        755                 760                 765             
Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly
    770                 775                 780                 
Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile
785                 790                 795                 800 
Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val
                805                 810                 815     
Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys
            820                 825                 830         
Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu
        835                 840                 845             
Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro
    850                 855                 860                 
Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe
865                 870                 875                 880 
Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser
                885                 890                 895     
Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His
            900                 905                 910         
Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile
        915                 920                 925             
Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser
    930                 935                 940                 
Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser
945                 950                 955                 960 
Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala
                965                 970                 975     
Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile
            980                 985                 990         
Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg Val Thr Cys Arg Leu
        995                 1000                1005            
Val Lys Arg His Arg Leu Ala Thr Met Pro Pro Met Val Glu Gly Glu
    1010                1015                1020                
Gly Leu Ala Ser Arg Leu Ile Glu Val Gly Pro Ser Gly Ala Gln Phe
1025                1030                1035                1040
Leu Gly Lys Leu His Leu Pro Thr Ala Pro Pro Pro Leu Asn Glu Gly
                1045                1050                1055    
Glu Ser Leu Val Ser Arg Ile Leu Gln Leu Gly Pro Pro Gly Thr Lys
            1060                1065                1070        
Phe Leu Gly Pro Val Ile Val Glu Ile Pro His Phe Ala Ala Leu Arg
        1075                1080                1085            
Gly Lys Glu Arg Glu Leu Val Val Leu Arg Ser Glu Asn Gly Asp Ser
    1090                1095                1100                
Trp Lys Glu His Phe Cys Asp Tyr Thr Glu Asp Glu Leu Asn Glu Ile
1105                1110                1115                1120
Leu Asn Gly Met Asp Glu Val Leu Asp Ser Pro Glu Asp Leu Glu Lys
                1125                1130                1135    
Lys Arg Ile Cys Arg Ile Ile Thr Arg Asp Phe Pro Gln Tyr Phe Ala
            1140                1145                1150        
Val Val Ser Arg Ile Lys Gln Asp Ser Asn Leu Ile Gly Pro Glu Gly
        1155                1160                1165            
Gly Val Leu Ser Ser Thr Val Val Pro Gln Val Gln Ala Val Phe Pro
    1170                1175                1180                
Glu Gly Ala Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro
1185                1190                1195                1200
Met His Ser Glu Leu Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe
                1205                1210                1215    
Ser Pro Ile Val Thr Leu Glu Pro Arg Arg Arg Lys Phe His Lys Pro
            1220                1225                1230        
Ile Thr Met Thr Ile Pro Val Pro Lys Ala Ser Ser Asp Val Met Leu
        1235                1240                1245            
Asn Gly Phe Gly Gly Asp Ala Pro Thr Leu Arg Leu Leu Cys Ser Ile
    1250                1255                1260                
Thr Gly Gly Thr Thr Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr
1265                1270                1275                1280
Pro Leu Thr Phe Val Asn Glu Cys Val Ser Phe Thr Thr Asn Val Ser
                1285                1290                1295    
Ala Arg Phe Trp Leu Ile Asp Cys Arg Gln Ile Gln Glu Ser Val Thr
            1300                1305                1310        
Phe Ala Ser Gln Val Tyr Arg Glu Ile Ile Cys Val Pro Tyr Met Ala
        1315                1320                1325            
Lys Phe Val Val Phe Ala Lys Ser His Asp Pro Ile Glu Ala Arg Leu
    1330                1335                1340                
Arg Cys Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln
1345                1350                1355                1360
Gln Glu Asn Phe Ala Glu Val Ala Arg Ser Arg Asp Val Glu Val Leu
                1365                1370                1375    
Glu Gly Lys Pro Ile Tyr Val Asp Cys Phe Gly Asn Leu Val Pro Leu
            1380                1385                1390        
Thr Lys Ser Gly Gln His His Ile Phe Ser Phe Phe Ala Phe Lys Glu
        1395                1400                1405            
Asn Arg Leu Pro Leu Phe Val Lys Val Arg Asp Thr Thr Gln Glu Pro
    1410                1415                1420                
Cys Gly Arg Leu Ser Phe Met Lys Glu Pro Lys Ser Thr Arg Gly Leu
1425                1430                1435                1440
Val His Gln Ala Ile Cys Asn Leu Asn Ile Thr Leu Pro Ile Tyr Thr
                1445                1450                1455    
Lys Glu Ser Glu Ser Asp Gln Glu Gln Glu Glu Glu Ile Asp Met Thr
            1460                1465                1470        
Ser Glu Lys Asn Asp Glu Thr Glu Ser Thr Glu Thr Ser Val Leu Lys
        1475                1480                1485            
Ser His Leu Val Asn Glu Val Pro Val Leu Ala Ser Pro Asp Leu Leu
    1490                1495                1500                
Ser Glu Val Ser Glu Met Lys Gln Asp Leu Ile Lys Met Thr Ala Ile
1505                1510                1515                1520
Leu Thr Thr Asp Val Ser Asp Lys Ala Gly Ser Ile Lys Val Lys Glu
                1525                1530                1535    
Leu Val Lys Ala Ala Glu Glu Glu Pro Gly Glu Pro Phe Glu Ile Val
            1540                1545                1550        
Glu Arg Val Lys Glu Asp Leu Glu Lys Val Asn Glu Ile Leu Arg Ser
        1555                1560                1565            
Gly Thr Cys Thr Arg Asp Glu Ser Ser Val Gln Ser Ser Arg Ser Glu
    1570                1575                1580                
Arg Gly Leu Val Glu Glu Glu Trp Val Ile Val Ser Asp Glu Glu Ile
1585                1590                1595                1600
Glu Glu Ala Arg Gln Lys Ala Pro Leu Glu Ile Thr Glu Tyr Pro Cys
                1605                1610                1615    
Val Glu Val Arg Ile Asp Lys Glu Ile Lys Gly Lys Val Glu Lys Asp
            1620                1625                1630        
Ser Thr Gly Leu Val Asn Tyr Leu Thr Asp Asp Leu Asn Thr Cys Val
        1635                1640                1645            
Pro Leu Pro Lys Glu Gln Leu Gln Thr Val Gln Asp Lys Ala Gly Lys
    1650                1655                1660                
Lys Cys Glu Ala Leu Ala Val Gly Arg Ser Ser Glu Lys Glu Gly Lys
1665                1670                1675                1680
Asp Ile Pro Pro Asp Glu Thr Gln Ser Thr Gln Lys Gln His Lys Pro
                1685                1690                1695    
Ser Leu Gly Ile Lys Lys Pro Val Arg Arg Lys Leu Lys Glu Lys Gln
            1700                1705                1710        
Lys Gln Lys Glu Glu Gly Leu Gln Ala Ser Ala Glu Lys Ala Glu Leu
        1715                1720                1725            
Lys Lys Gly Ser Ser Glu Glu Ser Leu Gly Glu Asp Pro Gly Leu Ala
    1730                1735                1740                
Pro Glu Pro Leu Pro Thr Val Lys Ala Thr Ser Pro Leu Ile Glu Glu
1745                1750                1755                1760
Thr Pro Ile Gly Ser Ile Lys Asp Lys Val Lys Ala Leu Gln Lys Arg
                1765                1770                1775    
Val Glu Asp Glu Gln Lys Gly Arg Ser Lys Leu Pro Ile Arg Val Lys
            1780                1785                1790        
Gly Lys Glu Asp Val Pro Lys Lys Thr Thr His Arg Pro His Pro Ala
        1795                1800                1805            
Ala Ser Pro Ser Leu Lys Ser Glu Arg His Ala Pro Gly Ser Pro Ser
    1810                1815                1820                
Pro Lys Thr Glu Arg His Ser Thr Leu Ser Ser Ser Ala Lys Thr Glu
1825                1830                1835                1840
Arg His Pro Pro Val Ser Pro Ser Ser Lys Thr Glu Lys His Ser Pro
                1845                1850                1855    
Val Ser Pro Ser Ala Lys Thr Glu Arg His Ser Pro Ala Ser Ser Ser
            1860                1865                1870        
Ser Lys Thr Glu Lys His Ser Pro Val Ser Pro Ser Thr Lys Thr Glu
        1875                1880                1885            
Arg His Ser Pro Val Ser Ser Thr Lys Thr Glu Arg His Pro Pro Val
    1890                1895                1900                
Ser Pro Ser Gly Lys Thr Asp Lys Arg Pro Pro Val Ser Pro Ser Gly
1905                1910                1915                1920
Arg Thr Glu Lys His Pro Pro Val Ser Pro Gly Arg Thr Glu Lys Arg
                1925                1930                1935    
Leu Pro Val Ser Pro Ser Gly Arg Thr Asp Lys His Gln Pro Val Ser
            1940                1945                1950        
Thr Ala Gly Lys Thr Glu Lys His Leu Pro Val Ser Pro Ser Gly Lys
        1955                1960                1965            
Thr Glu Lys Gln Pro Pro Val Ser Pro Thr Ser Lys Thr Glu Arg Ile
    1970                1975                1980                
Glu Glu Thr Met Ser Val Arg Glu Leu Met Lys Ala Phe Gln Ser Gly
1985                1990                1995                2000
Gln Asp Pro Ser Lys His Lys Thr Gly Leu Phe Glu His Lys Ser Ala
                2005                2010                2015    
Lys Gln Lys Gln Pro Gln Glu Lys Gly Lys Val Arg Val Glu Lys Glu
            2020                2025                2030        
Lys Gly Pro Ile Leu Thr Gln Arg Glu Ala Gln Lys Thr Glu Asn Gln
        2035                2040                2045            
Thr Ile Lys Arg Gly Gln Arg Leu Pro Val Thr Gly Thr Ala Glu Ser
    2050                2055                2060                
Lys Arg Gly Val Arg Val Ser Ser Ile Gly Val Lys Lys Glu Asp Ala
2065                2070                2075                2080
Ala Gly Gly Lys Glu Lys Val Leu Ser His Lys Ile Pro Glu Pro Val
                2085                2090                2095    
Gln Ser Val Pro Glu Glu Glu Ser His Arg Glu Ser Glu Val Pro Lys
            2100                2105                2110        
Glu Lys Met Ala Asp Glu Gln Gly Asp Met Asp Leu Gln Ile Ser Pro
        2115                2120                2125            
Asp Arg Lys Thr Ser Thr Asp Phe Ser Glu Val Ile Lys Gln Glu Leu
    2130                2135                2140                
Glu Asp Asn Asp Lys Tyr Gln Gln Phe Arg Leu Ser Glu Glu Thr Glu
2145                2150                2155                2160
Lys Ala Gln Leu His Leu Asp Gln Val Leu Thr Ser Pro Phe Asn Thr
                2165                2170                2175    
Thr Phe Pro Leu Asp Tyr Met Lys Asp Glu Phe Leu Pro Ala Leu Ser
            2180                2185                2190        
Leu Gln Ser Gly Ala Leu Asp Gly Ser Ser Glu Ser Leu Lys Asn Glu
        2195                2200                2205            
Gly Val Ala Gly Ser Pro Cys Gly Ser Leu Met Glu Gly Thr Pro Gln
    2210                2215                2220                
Ile Ser Ser Glu Glu Ser Tyr Lys His Glu Gly Leu Ala Glu Thr Pro
2225                2230                2235                2240
Glu Thr Ser Pro Glu Ser Leu Ser Phe Ser Pro Lys Lys Ser Glu Glu
                2245                2250                2255    
Gln Thr Gly Glu Thr Lys Glu Ser Thr Lys Thr Glu Thr Thr Thr Glu
            2260                2265                2270        
Ile Arg Ser Glu Lys Glu His Pro Thr Thr Lys Asp Ile Thr Gly Gly
        2275                2280                2285            
Ser Glu Glu Arg Gly Ala Thr Val Thr Glu Asp Ser Glu Thr Ser Thr
    2290                2295                2300                
Glu Ser Phe Gln Lys Glu Ala Thr Leu Gly Ser Pro Lys Asp Thr Ser
2305                2310                2315                2320
Pro Lys Arg Gln Asp Asp Cys Thr Gly Ser Cys Ser Val Ala Leu Ala
                2325                2330                2335    
Lys Glu Thr Pro Thr Gly Leu Thr Glu Glu Ala Ala Cys Asp Glu Gly
            2340                2345                2350        
Gln Arg Thr Phe Gly Ser Ser Ala His Lys Thr Gln Thr Asp Ser Glu
        2355                2360                2365            
Ala Gln Glu Ser Thr Ala Thr Ser Asp Glu Thr Lys Ala Leu Pro Leu
    2370                2375                2380                
Pro Glu Ala Ser Val Lys Thr Asp Thr Gly Thr Glu Ser Lys Pro Gln
2385                2390                2395                2400
Gly Val Ile Arg Ser Pro Gln Gly Leu Glu Leu Ala Leu Pro Ser Arg
                2405                2410                2415    
Asp Ser Glu Val Leu Ser Ala Val Ala Asp Asp Ser Leu Ala Val Ser
            2420                2425                2430        
His Lys Asp Ser Leu Glu Ala Ser Pro Val Leu Glu Asp Asn Ser Ser
        2435                2440                2445            
His Lys Thr Pro Asp Ser Leu Glu Pro Ser Pro Leu Lys Glu Ser Pro
    2450                2455                2460                
Cys Arg Asp Ser Leu Glu Ser Ser Pro Val Glu Pro Lys Met Lys Ala
2465                2470                2475                2480
Gly Ile Phe Pro Ser His Phe Pro Leu Pro Ala Ala Val Ala Lys Thr
                2485                2490                2495    
Glu Leu Leu Thr Glu Val Ala Ser Val Arg Ser Arg Leu Leu Arg Asp
            2500                2505                2510        
Pro Asp Gly Ser Ala Glu Asp Asp Ser Leu Glu Gln Thr Ser Leu Met
        2515                2520                2525            
Glu Ser Ser Gly Lys Ser Pro Leu Ser Pro Asp Thr Pro Ser Ser Glu
    2530                2535                2540                
Glu Val Ser Tyr Glu Val Thr Pro Lys Thr Thr Asp Val Ser Thr Pro
2545                2550                2555                2560
Lys Pro Ala Val Ile His Glu Cys Ala Glu Glu Asp Asp Ser Glu Asn
                2565                2570                2575    
Gly Glu Lys Lys Arg Phe Thr Pro Glu Glu Glu Met Phe Lys Met Val
            2580                2585                2590        
Thr Lys Ile Lys Met Phe Asp Glu Leu Glu Gln Glu Ala Lys Gln Lys
        2595                2600                2605            
Arg Asp Tyr Lys Lys Glu Pro Lys Gln Glu Glu Ser Ser Ser Ser Ser
    2610                2615                2620                
Asp Pro Asp Ala Asp Cys Ser Val Asp Val Asp Glu Pro Lys His Thr
2625                2630                2635                2640
Gly Ser Gly Glu Asp Glu Ser Gly Val Pro Val Leu Val Thr Ser Glu
                2645                2650                2655    
Ser Arg Lys Val Ser Ser Ser Ser Glu Ser Glu Pro Glu Leu Ala Gln
            2660                2665                2670        
Leu Lys Lys Gly Ala Asp Ser Gly Leu Leu Pro Glu Pro Val Ile Arg
        2675                2680                2685            
Val Gln Pro Pro Ser Pro Leu Pro Ser Ser Met Asp Ser Asn Ser Ser
    2690                2695                2700                
Pro Glu Glu Val Gln Phe Gln Pro Val Val Ser Lys Gln Tyr Thr Phe
2705                2710                2715                2720
Lys Met Asn Glu Asp Thr Gln Glu Glu Pro Gly Lys Ser Glu Glu Glu
                2725                2730                2735    
Lys Asp Ser Glu Ser His Leu Ala Glu Asp Arg His Ala Val Ser Thr
            2740                2745                2750        
Glu Ala Glu Asp Arg Ser Tyr Asp Lys Leu Asn Arg Asp Thr Asp Gln
        2755                2760                2765            
Pro Lys Ile Cys Asp Gly His Gly Cys Glu Ala Met Ser Pro Ser Ser
    2770                2775                2780                
Ser Ala Arg Pro Val Ser Ser Gly Leu Gln Ser Pro Thr Gly Asp Asp
2785                2790                2795                2800
Val Asp Glu Gln Pro Val Ile Tyr Lys Glu Ser Leu Ala Leu Gln Gly
                2805                2810                2815    
Thr His Glu Lys Asp Thr Glu Gly Glu Glu Leu Asp Val Ser Arg Ala
            2820                2825                2830        
Glu Ser Pro Gln Ala Asp Cys Pro Ser Glu Ser Phe Ser Ser Ser Ser
        2835                2840                2845            
Ser Leu Pro His Cys Leu Val Ser Glu Gly Lys Glu Leu Asp Glu Asp
    2850                2855                2860                
Ile Ser Ala Thr Ser Ser Ile Gln Lys Thr Glu Val Thr Lys Thr Asp
2865                2870                2875                2880
Glu Thr Phe Glu Asn Leu Pro Lys Asp Cys Pro Ser Gln Asp Ser Ser
                2885                2890                2895    
Ile Thr Thr Gln Thr Asp Arg Phe Ser Met Asp Val Pro Val Ser Asp
            2900                2905                2910        
Leu Ala Glu Asn Asp Glu Ile Tyr Asp Pro Gln Ile Thr Ser Pro Tyr
        2915                2920                2925            
Glu Asn Val Pro Ser Gln Ser Phe Phe Ser Ser Glu Glu Ser Lys Thr
    2930                2935                2940                
Gln Thr Asp Ala Asn His Thr Thr Ser Phe His Ser Ser Glu Val Tyr
2945                2950                2955                2960
Ser Val Thr Ile Thr Ser Pro Val Glu Asp Val Val Val Ala Ser Ser
                2965                2970                2975    
Ser Ser Gly Thr Val Leu Ser Lys Glu Ser Asn Phe Glu Gly Gln Asp
            2980                2985                2990        
Ile Lys Met Glu Ser Gln Leu Glu Ser Thr Leu Trp Glu Met Gln Ser
        2995                3000                3005            
Asp Ser Val Ser Ser Ser Phe Glu Pro Thr Met Ser Ala Thr Thr Thr
    3010                3015                3020                
Val Val Gly Glu Gln Ile Ser Lys Val Ile Ile Thr Lys Thr Asp Val
3025                3030                3035                3040
Asp Ser Asp Ser Trp Ser Glu Ile Arg Glu Asp Asp Glu Ala Phe Glu
                3045                3050                3055    
Ala Arg Val Lys Glu Glu Glu Gln Lys Ile Phe Gly Leu Met Val Asp
            3060                3065                3070        
Arg Gln Ser Gln Gly Thr Thr Pro Asp Thr Thr Pro Ala Arg Thr Pro
        3075                3080                3085            
Thr Glu Glu Gly Thr Pro Thr Ser Glu Gln Asn Pro Phe Leu Phe Gln
    3090                3095                3100                
Glu Gly Lys Leu Phe Glu Met Thr Arg Ser Gly Ala Ile Asp Met Thr
3105                3110                3115                3120
Lys Arg Ser Tyr Ala Asp Glu Ser Phe His Phe Phe Gln Ile Gly Gln
                3125                3130                3135    
Glu Ser Arg Glu Glu Thr Leu Ser Glu Asp Val Lys Glu Gly Ala Thr
            3140                3145                3150        
Gly Ala Asp Pro Leu Pro Leu Glu Thr Ser Ala Glu Ser Leu Ala Leu
        3155                3160                3165            
Ser Glu Ser Lys Glu Thr Val Asp Asp Glu Ala Asp Leu Leu Pro Asp
    3170                3175                3180                
Ser Val Ser Glu Glu Val Glu Glu Ile Pro Ala Ser Asp Ala Gln Leu
3185                3190                3195                3200
Asn Ser Gln Met Gly Ile Ser Ala Ser Thr Glu Thr Pro Thr Lys Glu
                3205                3210                3215    
Ala Val Ser Val Gly Thr Lys Asp Leu Pro Thr Val Gln Thr Gly Asp
            3220                3225                3230        
Ile Pro Pro Leu Ser Gly Val Lys Gln Ile Ser Cys Pro Asp Ser Ser
        3235                3240                3245            
Glu Pro Ala Val Gln Val Gln Leu Asp Phe Ser Thr Leu Thr Arg Ser
    3250                3255                3260                
Val Tyr Ser Asp Arg Gly Asp Asp Ser Pro Asp Ser Ser Pro Glu Glu
3265                3270                3275                3280
Gln Lys Ser Val Ile Glu Ile Pro Thr Ala Pro Met Glu Asn Val Pro
                3285                3290                3295    
Phe Thr Glu Ser Lys Ser Lys Ile Pro Val Arg Thr Met Pro Thr Ser
            3300                3305                3310        
Thr Pro Ala Pro Pro Ser Ala Glu Tyr Glu Ser Ser Val Ser Glu Asp
        3315                3320                3325            
Phe Leu Ser Ser Val Asp Glu Glu Asn Lys Ala Asp Glu Ala Lys Pro
    3330                3335                3340                
Lys Ser Lys Leu Pro Val Lys Val Pro Leu Gln Arg Val Glu Gln Gln
3345                3350                3355                3360
Leu Ser Asp Leu Asp Thr Ser Val Gln Lys Thr Val Ala Pro Gln Gly
                3365                3370                3375    
Gln Asp Met Ala Ser Ile Ala Pro Asp Asn Arg Ser Lys Ser Glu Ser
            3380                3385                3390        
Asp Ala Ser Ser Leu Asp Ser Lys Thr Lys Cys Pro Val Lys Thr Arg
        3395                3400                3405            
Ser Tyr Thr Glu Thr Glu Thr Glu Ser Arg Glu Arg Ala Glu Glu Leu
    3410                3415                3420                
Glu Leu Glu Ser Glu Glu Gly Ala Thr Arg Pro Lys Ile Leu Thr Ser
3425                3430                3435                3440
Arg Leu Pro Val Lys Ser Arg Ser Thr Thr Ser Ser Cys Arg Gly Gly
                3445                3450                3455    
Thr Ser Pro Thr Lys Glu Ser Lys Glu His Phe Phe Asp Leu Tyr Arg
            3460                3465                3470        
Asn Ser Ile Glu Phe Phe Glu Glu Ile Ser Asp Glu Ala Ser Lys Leu
        3475                3480                3485            
Val Asp Arg Leu Thr Gln Ser Glu Arg Glu Gln Glu Ile Val Ser Asp
    3490                3495                3500                
Asp Glu Ser Ser Ser Ala Leu Glu Val Ser Val Ile Glu Asn Leu Pro
3505                3510                3515                3520
Pro Val Glu Thr Glu His Ser Val Pro Glu Asp Ile Phe Asp Thr Arg
                3525                3530                3535    
Pro Ile Trp Asp Glu Ser Ile Glu Thr Leu Ile Glu Arg Ile Pro Asp
            3540                3545                3550        
Glu Asn Gly His Asp His Ala Glu Asp Pro Gln Asp Glu Gln Glu Arg
        3555                3560                3565            
Ile Glu Glu Arg Leu Ala Tyr Ile Ala Asp His Leu Gly Phe Ser Trp
    3570                3575                3580                
Thr Glu Leu Ala Arg Glu Leu Asp Phe Thr Glu Glu Gln Ile His Gln
3585                3590                3595                3600
Ile Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp Gln Ser His Ala Leu
                3605                3610                3615    
Leu Lys Tyr Trp Leu Glu Arg Asp Gly Lys His Ala Thr Asp Thr Asn
            3620                3625                3630        
Leu Val Glu Cys Leu Thr Lys Ile Asn Arg Met Asp Ile Val His Leu
        3635                3640                3645            
Met Glu Thr Asn Thr Glu Pro Leu Gln Glu Arg Ile Ser His Ser Tyr
    3650                3655                3660                
Ala Glu Ile Glu Gln Thr Ile Thr Leu Asp His Ser Glu Gly Phe Ser
3665                3670                3675                3680
Val Leu Gln Glu Glu Leu Cys Thr Ala Gln His Lys Gln Lys Glu Glu
                3685                3690                3695    
Gln Ala Val Ser Lys Glu Ser Glu Thr Cys Asp His Pro Pro Ile Val
            3700                3705                3710        
Ser Glu Glu Asp Ile Ser Val Gly Tyr Ser Thr Phe Gln Asp Gly Val
        3715                3720                3725            
Pro Lys Thr Glu Gly Asp Ser Ser Ser Thr Ala Leu Phe Pro Gln Thr
    3730                3735                3740                
His Lys Glu Gln Val Gln Gln Asp Phe Ser Gly Lys Met Gln Asp Leu
3745                3750                3755                3760
Pro Glu Glu Ser Ser Leu Glu Tyr Gln Gln Glu Tyr Phe Val Thr Thr
                3765                3770                3775    
Pro Gly Thr Glu Thr Ser Glu Thr Gln Lys Ala Met Ile Val Pro Ser
            3780                3785                3790        
Ser Pro Ser Lys Thr Pro Glu Glu Val Ser Thr Pro Ala Glu Glu Glu
        3795                3800                3805            
Lys Leu Tyr Leu Gln Thr Pro Thr Ser Ser Glu Arg Gly Gly Ser Pro
    3810                3815                3820                
Ile Ile Gln Glu Pro Glu Glu Pro Ser Glu His Arg Glu Glu Ser Ser
3825                3830                3835                3840
Pro Arg Lys Thr Ser Leu Val Ile Val Glu Ser Ala Asp Asn Gln Pro
                3845                3850                3855    
Glu Thr Cys Glu Arg Leu Asp Glu Asp Ala Ala Phe Glu Lys Gly Asp
            3860                3865                3870        
Asp Met Pro Glu Ile Pro Pro Glu Thr Val Thr Glu Glu Glu Tyr Ile
        3875                3880                3885            
Asp Glu His Gly His Thr Val Val Lys Lys Val Thr Arg Lys Ile Ile
    3890                3895                3900                
Arg Arg Tyr Val Ser Ser Glu Gly Thr Glu Lys Glu Glu Ile Met Val
3905                3910                3915                3920
Gln Gly Met Pro Gln Glu Pro Val Asn Ile Glu Glu Gly Asp Gly Tyr
                3925                3930                3935    
Ser Lys Val Ile Lys Arg Val Val Leu Lys Ser Asp Thr Glu Gln Ser
            3940                3945                3950        
Glu Asp Asn Asn Glu
        3955        


<210> 7031
<211> 3924
<212> PRT
<213> Homo sapiens

<400> 7031
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe
 1               5                  10                  15      
Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn
            20                  25                  30          
Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val
        35                  40                  45              
Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly
    50                  55                  60                  
Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val
65                  70                  75                  80  
Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys
                85                  90                  95      
Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val
            100                 105                 110         
Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln
        115                 120                 125             
Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp
    130                 135                 140                 
Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr
145                 150                 155                 160 
Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn
                165                 170                 175     
Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg
            180                 185                 190         
Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala
        195                 200                 205             
Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met
    210                 215                 220                 
Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala
225                 230                 235                 240 
Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly
                245                 250                 255     
Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val
            260                 265                 270         
Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg
        275                 280                 285             
Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His
    290                 295                 300                 
Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu
305                 310                 315                 320 
Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu
                325                 330                 335     
His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu
            340                 345                 350         
Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala
        355                 360                 365             
Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu
    370                 375                 380                 
Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr
385                 390                 395                 400 
Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu
                405                 410                 415     
Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu
            420                 425                 430         
Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu
        435                 440                 445             
Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly
    450                 455                 460                 
Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val
465                 470                 475                 480 
Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu
                485                 490                 495     
Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile
            500                 505                 510         
Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr
        515                 520                 525             
Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp
    530                 535                 540                 
Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr
545                 550                 555                 560 
Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu
                565                 570                 575     
Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala
            580                 585                 590         
Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn
        595                 600                 605             
Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala
    610                 615                 620                 
Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn
625                 630                 635                 640 
Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn
                645                 650                 655     
Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu
            660                 665                 670         
Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile
        675                 680                 685             
His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln
    690                 695                 700                 
Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp
705                 710                 715                 720 
Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys
                725                 730                 735     
His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala
            740                 745                 750         
Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala
        755                 760                 765             
Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly
    770                 775                 780                 
Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile
785                 790                 795                 800 
Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val
                805                 810                 815     
Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys
            820                 825                 830         
Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu
        835                 840                 845             
Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro
    850                 855                 860                 
Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe
865                 870                 875                 880 
Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser
                885                 890                 895     
Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His
            900                 905                 910         
Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile
        915                 920                 925             
Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser
    930                 935                 940                 
Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser
945                 950                 955                 960 
Ser Ser Pro Ile His Ser Gly Phe Leu Val Ile Phe Met Val Asp Ala
                965                 970                 975     
Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile
            980                 985                 990         
Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg Val Thr Cys Arg Leu
        995                 1000                1005            
Val Lys Arg His Arg Leu Ala Thr Met Pro Pro Met Val Glu Gly Glu
    1010                1015                1020                
Gly Leu Ala Ser Arg Leu Ile Glu Val Gly Pro Ser Gly Ala Gln Phe
1025                1030                1035                1040
Leu Gly Pro Val Ile Val Glu Ile Pro His Phe Ala Ala Leu Arg Gly
                1045                1050                1055    
Lys Glu Arg Glu Leu Val Val Leu Arg Ser Glu Asn Gly Asp Ser Trp
            1060                1065                1070        
Lys Glu His Phe Cys Asp Tyr Thr Glu Asp Glu Leu Asn Glu Ile Leu
        1075                1080                1085            
Asn Gly Met Asp Glu Val Leu Asp Ser Pro Glu Asp Leu Glu Lys Lys
    1090                1095                1100                
Arg Ile Cys Arg Ile Ile Thr Arg Asp Phe Pro Gln Tyr Phe Ala Val
1105                1110                1115                1120
Val Ser Arg Ile Lys Gln Asp Ser Asn Leu Ile Gly Pro Glu Gly Gly
                1125                1130                1135    
Val Leu Ser Ser Thr Val Val Pro Gln Val Gln Ala Val Phe Pro Glu
            1140                1145                1150        
Gly Ala Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Met
        1155                1160                1165            
His Ser Glu Leu Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser
    1170                1175                1180                
Pro Ile Val Thr Leu Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile
1185                1190                1195                1200
Thr Met Thr Ile Pro Val Pro Lys Ala Ser Ser Asp Val Met Leu Asn
                1205                1210                1215    
Gly Phe Gly Gly Asp Ala Pro Thr Leu Arg Leu Leu Cys Ser Ile Thr
            1220                1225                1230        
Gly Gly Thr Thr Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro
        1235                1240                1245            
Leu Thr Phe Val Asn Glu Cys Val Ser Phe Thr Thr Asn Val Ser Ala
    1250                1255                1260                
Arg Phe Trp Leu Ile Asp Cys Arg Gln Ile Gln Glu Ser Val Thr Phe
1265                1270                1275                1280
Ala Ser Gln Val Tyr Arg Glu Ile Ile Cys Val Pro Tyr Met Ala Lys
                1285                1290                1295    
Phe Val Val Phe Ala Lys Ser His Asp Pro Ile Glu Ala Arg Leu Arg
            1300                1305                1310        
Cys Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln
        1315                1320                1325            
Glu Asn Phe Ala Glu Val Ala Arg Ser Arg Asp Val Glu Val Leu Glu
    1330                1335                1340                
Gly Lys Pro Ile Tyr Val Asp Cys Phe Gly Asn Leu Val Pro Leu Thr
1345                1350                1355                1360
Lys Ser Gly Gln His His Ile Phe Ser Phe Phe Ala Phe Lys Glu Asn
                1365                1370                1375    
Arg Leu Pro Leu Phe Val Lys Val Arg Asp Thr Thr Gln Glu Pro Cys
            1380                1385                1390        
Gly Arg Leu Ser Phe Met Lys Glu Pro Lys Ser Thr Arg Gly Leu Val
        1395                1400                1405            
His Gln Ala Ile Cys Asn Leu Asn Ile Thr Leu Pro Ile Tyr Thr Lys
    1410                1415                1420                
Glu Ser Glu Ser Asp Gln Glu Gln Glu Glu Glu Ile Asp Met Thr Ser
1425                1430                1435                1440
Glu Lys Asn Asp Glu Thr Glu Ser Thr Glu Thr Ser Val Leu Lys Ser
                1445                1450                1455    
His Leu Val Asn Glu Val Pro Val Leu Ala Ser Pro Asp Leu Leu Ser
            1460                1465                1470        
Glu Val Ser Glu Met Lys Gln Asp Leu Ile Lys Met Thr Ala Ile Leu
        1475                1480                1485            
Thr Thr Asp Val Ser Asp Lys Ala Gly Ser Ile Lys Val Lys Glu Leu
    1490                1495                1500                
Val Lys Ala Ala Glu Glu Glu Pro Gly Glu Pro Phe Glu Ile Val Glu
1505                1510                1515                1520
Arg Val Lys Glu Asp Leu Glu Lys Val Asn Glu Ile Leu Arg Ser Gly
                1525                1530                1535    
Thr Cys Thr Arg Asp Glu Ser Ser Val Gln Ser Ser Arg Ser Glu Arg
            1540                1545                1550        
Gly Leu Val Glu Glu Glu Trp Val Ile Val Ser Asp Glu Glu Ile Glu
        1555                1560                1565            
Glu Ala Arg Gln Lys Ala Pro Leu Glu Ile Thr Glu Tyr Pro Cys Val
    1570                1575                1580                
Glu Val Arg Ile Asp Lys Glu Ile Lys Gly Lys Val Glu Lys Asp Ser
1585                1590                1595                1600
Thr Gly Leu Val Asn Tyr Leu Thr Asp Asp Leu Asn Thr Cys Val Pro
                1605                1610                1615    
Leu Pro Lys Glu Gln Leu Gln Thr Val Gln Asp Lys Ala Gly Lys Lys
            1620                1625                1630        
Cys Glu Ala Leu Ala Val Gly Arg Ser Ser Glu Lys Glu Gly Lys Asp
        1635                1640                1645            
Ile Pro Pro Asp Glu Thr Gln Ser Thr Gln Lys Gln His Lys Pro Ser
    1650                1655                1660                
Leu Gly Ile Lys Lys Pro Val Arg Arg Lys Leu Lys Glu Lys Gln Lys
1665                1670                1675                1680
Gln Lys Glu Glu Gly Leu Gln Ala Ser Ala Glu Lys Ala Glu Leu Lys
                1685                1690                1695    
Lys Gly Ser Ser Glu Glu Ser Leu Gly Glu Asp Pro Gly Leu Ala Pro
            1700                1705                1710        
Glu Pro Leu Pro Thr Val Lys Ala Thr Ser Pro Leu Ile Glu Glu Thr
        1715                1720                1725            
Pro Ile Gly Ser Ile Lys Asp Lys Val Lys Ala Leu Gln Lys Arg Val
    1730                1735                1740                
Glu Asp Glu Gln Lys Gly Arg Ser Lys Leu Pro Ile Arg Val Lys Gly
1745                1750                1755                1760
Lys Glu Asp Val Pro Lys Lys Thr Thr His Arg Pro His Pro Ala Ala
                1765                1770                1775    
Ser Pro Ser Leu Lys Ser Glu Arg His Ala Pro Gly Ser Pro Ser Pro
            1780                1785                1790        
Lys Thr Glu Arg His Ser Thr Leu Ser Ser Ser Ala Lys Thr Glu Arg
        1795                1800                1805            
His Pro Pro Val Ser Pro Ser Ser Lys Thr Glu Lys His Ser Pro Val
    1810                1815                1820                
Ser Pro Ser Ala Lys Thr Glu Arg His Ser Pro Ala Ser Ser Ser Ser
1825                1830                1835                1840
Lys Thr Glu Lys His Ser Pro Val Ser Pro Ser Thr Lys Thr Glu Arg
                1845                1850                1855    
His Ser Pro Val Ser Ser Thr Lys Thr Glu Arg His Pro Pro Val Ser
            1860                1865                1870        
Pro Ser Gly Lys Thr Asp Lys Arg Pro Pro Val Ser Pro Ser Gly Arg
        1875                1880                1885            
Thr Glu Lys His Pro Pro Val Ser Pro Gly Arg Thr Glu Lys Arg Leu
    1890                1895                1900                
Pro Val Ser Pro Ser Gly Arg Thr Asp Lys His Gln Pro Val Ser Thr
1905                1910                1915                1920
Ala Gly Lys Thr Glu Lys His Leu Pro Val Ser Pro Ser Gly Lys Thr
                1925                1930                1935    
Glu Lys Gln Pro Pro Val Ser Pro Thr Ser Lys Thr Glu Arg Ile Glu
            1940                1945                1950        
Glu Thr Met Ser Val Arg Glu Leu Met Lys Ala Phe Gln Ser Gly Gln
        1955                1960                1965            
Asp Pro Ser Lys His Lys Thr Gly Leu Phe Glu His Lys Ser Ala Lys
    1970                1975                1980                
Gln Lys Gln Pro Gln Glu Lys Gly Lys Val Arg Val Glu Lys Glu Lys
1985                1990                1995                2000
Gly Pro Ile Leu Thr Gln Arg Glu Ala Gln Lys Thr Glu Asn Gln Thr
                2005                2010                2015    
Ile Lys Arg Gly Gln Arg Leu Pro Val Thr Gly Thr Ala Glu Ser Lys
            2020                2025                2030        
Arg Gly Val Arg Val Ser Ser Ile Gly Val Lys Lys Glu Asp Ala Ala
        2035                2040                2045            
Gly Gly Lys Glu Lys Val Leu Ser His Lys Ile Pro Glu Pro Val Gln
    2050                2055                2060                
Ser Val Pro Glu Glu Glu Ser His Arg Glu Ser Glu Val Pro Lys Glu
2065                2070                2075                2080
Lys Met Ala Asp Glu Gln Gly Asp Met Asp Leu Gln Ile Ser Pro Asp
                2085                2090                2095    
Arg Lys Thr Ser Thr Asp Phe Ser Glu Val Ile Lys Gln Glu Leu Glu
            2100                2105                2110        
Asp Asn Asp Lys Tyr Gln Gln Phe Arg Leu Ser Glu Glu Thr Glu Lys
        2115                2120                2125            
Ala Gln Leu His Leu Asp Gln Val Leu Thr Ser Pro Phe Asn Thr Thr
    2130                2135                2140                
Phe Pro Leu Asp Tyr Met Lys Asp Glu Phe Leu Pro Ala Leu Ser Leu
2145                2150                2155                2160
Gln Ser Gly Ala Leu Asp Gly Ser Ser Glu Ser Leu Lys Asn Glu Gly
                2165                2170                2175    
Val Ala Gly Ser Pro Cys Gly Ser Leu Met Glu Gly Thr Pro Gln Ile
            2180                2185                2190        
Ser Ser Glu Glu Ser Tyr Lys His Glu Gly Leu Ala Glu Thr Pro Glu
        2195                2200                2205            
Thr Ser Pro Glu Ser Leu Ser Phe Ser Pro Lys Lys Ser Glu Glu Gln
    2210                2215                2220                
Thr Gly Glu Thr Lys Glu Ser Thr Lys Thr Glu Thr Thr Thr Glu Ile
2225                2230                2235                2240
Arg Ser Glu Lys Glu His Pro Thr Thr Lys Asp Ile Thr Gly Gly Ser
                2245                2250                2255    
Glu Glu Arg Gly Ala Thr Val Thr Glu Asp Ser Glu Thr Ser Thr Glu
            2260                2265                2270        
Ser Phe Gln Lys Glu Ala Thr Leu Gly Ser Pro Lys Asp Thr Ser Pro
        2275                2280                2285            
Lys Arg Gln Asp Asp Cys Thr Gly Ser Cys Ser Val Ala Leu Ala Lys
    2290                2295                2300                
Glu Thr Pro Thr Gly Leu Thr Glu Glu Ala Ala Cys Asp Glu Gly Gln
2305                2310                2315                2320
Arg Thr Phe Gly Ser Ser Ala His Lys Thr Gln Thr Asp Ser Glu Ala
                2325                2330                2335    
Gln Glu Ser Thr Ala Thr Ser Asp Glu Thr Lys Ala Leu Pro Leu Pro
            2340                2345                2350        
Glu Ala Ser Val Lys Thr Asp Thr Gly Thr Glu Ser Lys Pro Gln Gly
        2355                2360                2365            
Val Ile Arg Ser Pro Gln Gly Leu Glu Leu Ala Leu Pro Ser Arg Asp
    2370                2375                2380                
Ser Glu Val Leu Ser Ala Val Ala Asp Asp Ser Leu Ala Val Ser His
2385                2390                2395                2400
Lys Asp Ser Leu Glu Ala Ser Pro Val Leu Glu Asp Asn Ser Ser His
                2405                2410                2415    
Lys Thr Pro Asp Ser Leu Glu Pro Ser Pro Leu Lys Glu Ser Pro Cys
            2420                2425                2430        
Arg Asp Ser Leu Glu Ser Ser Pro Val Glu Pro Lys Met Lys Ala Gly
        2435                2440                2445            
Ile Phe Pro Ser His Phe Pro Leu Pro Ala Ala Val Ala Lys Thr Glu
    2450                2455                2460                
Leu Leu Thr Glu Val Ala Ser Val Arg Ser Arg Leu Leu Arg Asp Pro
2465                2470                2475                2480
Asp Gly Ser Ala Glu Asp Asp Ser Leu Glu Gln Thr Ser Leu Met Glu
                2485                2490                2495    
Ser Ser Gly Lys Ser Pro Leu Ser Pro Asp Thr Pro Ser Ser Glu Glu
            2500                2505                2510        
Val Ser Tyr Glu Val Thr Pro Lys Thr Thr Asp Val Ser Thr Pro Lys
        2515                2520                2525            
Pro Ala Val Ile His Glu Cys Ala Glu Glu Asp Asp Ser Glu Asn Gly
    2530                2535                2540                
Glu Lys Lys Arg Phe Thr Pro Glu Glu Glu Met Phe Lys Met Val Thr
2545                2550                2555                2560
Lys Ile Lys Met Phe Asp Glu Leu Glu Gln Glu Ala Lys Gln Lys Arg
                2565                2570                2575    
Asp Tyr Lys Lys Glu Pro Lys Gln Glu Glu Ser Ser Ser Ser Ser Asp
            2580                2585                2590        
Pro Asp Ala Asp Cys Ser Val Asp Val Asp Glu Pro Lys His Thr Gly
        2595                2600                2605            
Ser Gly Glu Asp Glu Ser Gly Val Pro Val Leu Val Thr Ser Glu Ser
    2610                2615                2620                
Arg Lys Val Ser Ser Ser Ser Glu Ser Glu Pro Glu Leu Ala Gln Leu
2625                2630                2635                2640
Lys Lys Gly Ala Asp Ser Gly Leu Leu Pro Glu Pro Val Ile Arg Val
                2645                2650                2655    
Gln Pro Pro Ser Pro Leu Pro Ser Ser Met Asp Ser Asn Ser Ser Pro
            2660                2665                2670        
Glu Glu Val Gln Phe Gln Pro Val Val Ser Lys Gln Tyr Thr Phe Lys
        2675                2680                2685            
Met Asn Glu Asp Thr Gln Glu Glu Pro Gly Lys Ser Glu Glu Glu Lys
    2690                2695                2700                
Asp Ser Glu Ser His Leu Ala Glu Asp Arg His Ala Val Ser Thr Glu
2705                2710                2715                2720
Ala Glu Asp Arg Ser Tyr Asp Lys Leu Asn Arg Asp Thr Asp Gln Pro
                2725                2730                2735    
Lys Ile Cys Asp Gly His Gly Cys Glu Ala Met Ser Pro Ser Ser Ser
            2740                2745                2750        
Ala Arg Pro Val Ser Ser Gly Leu Gln Ser Pro Thr Gly Asp Asp Val
        2755                2760                2765            
Asp Glu Gln Pro Val Ile Tyr Lys Glu Ser Leu Ala Leu Gln Gly Thr
    2770                2775                2780                
His Glu Lys Asp Thr Glu Gly Glu Glu Leu Asp Val Ser Arg Ala Glu
2785                2790                2795                2800
Ser Pro Gln Ala Asp Cys Pro Ser Glu Ser Phe Ser Ser Ser Ser Ser
                2805                2810                2815    
Leu Pro His Cys Leu Val Ser Glu Gly Lys Glu Leu Asp Glu Asp Ile
            2820                2825                2830        
Ser Ala Thr Ser Ser Ile Gln Lys Thr Glu Val Thr Lys Thr Asp Glu
        2835                2840                2845            
Thr Phe Glu Asn Leu Pro Lys Asp Cys Pro Ser Gln Asp Ser Ser Ile
    2850                2855                2860                
Thr Thr Gln Thr Asp Arg Phe Ser Met Asp Val Pro Val Ser Asp Leu
2865                2870                2875                2880
Ala Glu Asn Asp Glu Ile Tyr Asp Pro Gln Ile Thr Ser Pro Tyr Glu
                2885                2890                2895    
Asn Val Pro Ser Gln Ser Phe Phe Ser Ser Glu Glu Ser Lys Thr Gln
            2900                2905                2910        
Thr Asp Ala Asn His Thr Thr Ser Phe His Ser Ser Glu Val Tyr Ser
        2915                2920                2925            
Val Thr Ile Thr Ser Pro Val Glu Asp Val Val Val Ala Ser Ser Ser
    2930                2935                2940                
Ser Gly Thr Val Leu Ser Lys Glu Ser Asn Phe Glu Gly Gln Asp Ile
2945                2950                2955                2960
Lys Met Glu Ser Gln Leu Glu Ser Thr Leu Trp Glu Met Gln Ser Asp
                2965                2970                2975    
Ser Val Ser Ser Ser Phe Glu Pro Thr Met Ser Ala Thr Thr Thr Val
            2980                2985                2990        
Val Gly Glu Gln Ile Ser Lys Val Ile Ile Thr Lys Thr Asp Val Asp
        2995                3000                3005            
Ser Asp Ser Trp Ser Glu Ile Arg Glu Asp Asp Glu Ala Phe Glu Ala
    3010                3015                3020                
Arg Val Lys Glu Glu Glu Gln Lys Ile Phe Gly Leu Met Val Asp Arg
3025                3030                3035                3040
Gln Ser Gln Gly Thr Thr Pro Asp Thr Thr Pro Ala Arg Thr Pro Thr
                3045                3050                3055    
Glu Glu Gly Thr Pro Thr Ser Glu Gln Asn Pro Phe Leu Phe Gln Glu
            3060                3065                3070        
Gly Lys Leu Phe Glu Met Thr Arg Ser Gly Ala Ile Asp Met Thr Lys
        3075                3080                3085            
Arg Ser Tyr Ala Asp Glu Ser Phe His Phe Phe Gln Ile Gly Gln Glu
    3090                3095                3100                
Ser Arg Glu Glu Thr Leu Ser Glu Asp Val Lys Glu Gly Ala Thr Gly
3105                3110                3115                3120
Ala Asp Pro Leu Pro Leu Glu Thr Ser Ala Glu Ser Leu Ala Leu Ser
                3125                3130                3135    
Glu Ser Lys Glu Thr Val Asp Asp Glu Ala Asp Leu Leu Pro Asp Ser
            3140                3145                3150        
Val Ser Glu Glu Val Glu Glu Ile Pro Ala Ser Asp Ala Gln Leu Asn
        3155                3160                3165            
Ser Gln Met Gly Ile Ser Ala Ser Thr Glu Thr Pro Thr Lys Glu Ala
    3170                3175                3180                
Val Ser Val Gly Thr Lys Asp Leu Pro Thr Val Gln Thr Gly Asp Ile
3185                3190                3195                3200
Pro Pro Leu Ser Gly Val Lys Gln Ile Ser Cys Pro Asp Ser Ser Glu
                3205                3210                3215    
Pro Ala Val Gln Val Gln Leu Asp Phe Ser Thr Leu Thr Arg Ser Val
            3220                3225                3230        
Tyr Ser Asp Arg Gly Asp Asp Ser Pro Asp Ser Ser Pro Glu Glu Gln
        3235                3240                3245            
Lys Ser Val Ile Glu Ile Pro Thr Ala Pro Met Glu Asn Val Pro Phe
    3250                3255                3260                
Thr Glu Ser Lys Ser Lys Ile Pro Val Arg Thr Met Pro Thr Ser Thr
3265                3270                3275                3280
Pro Ala Pro Pro Ser Ala Glu Tyr Glu Ser Ser Val Ser Glu Asp Phe
                3285                3290                3295    
Leu Ser Ser Val Asp Glu Glu Asn Lys Ala Asp Glu Ala Lys Pro Lys
            3300                3305                3310        
Ser Lys Leu Pro Val Lys Val Pro Leu Gln Arg Val Glu Gln Gln Leu
        3315                3320                3325            
Ser Asp Leu Asp Thr Ser Val Gln Lys Thr Val Ala Pro Gln Gly Gln
    3330                3335                3340                
Asp Met Ala Ser Ile Ala Pro Asp Asn Arg Ser Lys Ser Glu Ser Asp
3345                3350                3355                3360
Ala Ser Ser Leu Asp Ser Lys Thr Lys Cys Pro Val Lys Thr Arg Ser
                3365                3370                3375    
Tyr Thr Glu Thr Glu Thr Glu Ser Arg Glu Arg Ala Glu Glu Leu Glu
            3380                3385                3390        
Leu Glu Ser Glu Glu Gly Ala Thr Arg Pro Lys Ile Leu Thr Ser Arg
        3395                3400                3405            
Leu Pro Val Lys Ser Arg Ser Thr Thr Ser Ser Cys Arg Gly Gly Thr
    3410                3415                3420                
Ser Pro Thr Lys Glu Ser Lys Glu His Phe Phe Asp Leu Tyr Arg Asn
3425                3430                3435                3440
Ser Ile Glu Phe Phe Glu Glu Ile Ser Asp Glu Ala Ser Lys Leu Val
                3445                3450                3455    
Asp Arg Leu Thr Gln Ser Glu Arg Glu Gln Glu Ile Val Ser Asp Asp
            3460                3465                3470        
Glu Ser Ser Ser Ala Leu Glu Val Ser Val Ile Glu Asn Leu Pro Pro
        3475                3480                3485            
Val Glu Thr Glu His Ser Val Pro Glu Asp Ile Phe Asp Thr Arg Pro
    3490                3495                3500                
Ile Trp Asp Glu Ser Ile Glu Thr Leu Ile Glu Arg Ile Pro Asp Glu
3505                3510                3515                3520
Asn Gly His Asp His Ala Glu Asp Pro Gln Asp Glu Gln Glu Arg Ile
                3525                3530                3535    
Glu Glu Arg Leu Ala Tyr Ile Ala Asp His Leu Gly Phe Ser Trp Thr
            3540                3545                3550        
Glu Leu Ala Arg Glu Leu Asp Phe Thr Glu Glu Gln Ile His Gln Ile
        3555                3560                3565            
Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp Gln Ser Gln Tyr Leu Leu
    3570                3575                3580                
Lys Ile Trp Leu Glu Arg Asp Gly Lys His Ala Thr Asp Thr Asn Leu
3585                3590                3595                3600
Val Glu Cys Leu Thr Lys Ile Asn Arg Met Asp Ile Val His Leu Met
                3605                3610                3615    
Glu Thr Asn Thr Glu Pro Leu Gln Glu Arg Ile Ser His Ser Tyr Ala
            3620                3625                3630        
Glu Ile Glu Gln Thr Ile Thr Leu Asp His Ser Glu Gly Phe Ser Val
        3635                3640                3645            
Leu Gln Glu Glu Leu Cys Thr Ala Gln His Lys Gln Lys Glu Glu Gln
    3650                3655                3660                
Ala Val Ser Lys Glu Ser Glu Thr Cys Asp His Pro Pro Ile Val Ser
3665                3670                3675                3680
Glu Glu Asp Ile Ser Val Gly Tyr Ser Thr Phe Gln Asp Gly Val Pro
                3685                3690                3695    
Lys Thr Glu Gly Asp Ser Ser Ser Thr Ala Leu Phe Pro Gln Thr His
            3700                3705                3710        
Lys Glu Gln Val Gln Gln Asp Phe Ser Gly Lys Met Gln Asp Leu Pro
        3715                3720                3725            
Glu Glu Ser Ser Leu Glu Tyr Gln Gln Glu Tyr Phe Val Thr Thr Pro
    3730                3735                3740                
Gly Thr Glu Thr Ser Glu Thr Gln Lys Ala Met Ile Val Pro Ser Ser
3745                3750                3755                3760
Pro Ser Lys Thr Pro Glu Glu Val Ser Thr Pro Ala Glu Glu Glu Lys
                3765                3770                3775    
Leu Tyr Leu Gln Thr Pro Thr Ser Ser Glu Arg Gly Gly Ser Pro Ile
            3780                3785                3790        
Ile Gln Glu Pro Glu Glu Pro Ser Glu His Arg Glu Glu Ser Ser Pro
        3795                3800                3805            
Arg Lys Thr Ser Leu Val Ile Val Glu Ser Ala Asp Asn Gln Pro Glu
    3810                3815                3820                
Thr Cys Glu Arg Leu Asp Glu Asp Ala Ala Phe Glu Lys Gly Asp Asp
3825                3830                3835                3840
Met Pro Glu Ile Pro Pro Glu Thr Val Thr Glu Glu Glu Tyr Ile Asp
                3845                3850                3855    
Glu His Gly His Thr Val Val Lys Lys Val Thr Arg Lys Ile Ile Arg
            3860                3865                3870        
Arg Tyr Val Ser Ser Glu Gly Thr Glu Lys Glu Glu Ile Met Val Gln
        3875                3880                3885            
Gly Met Pro Gln Glu Pro Val Asn Ile Glu Glu Gly Asp Gly Tyr Ser
    3890                3895                3900                
Lys Val Ile Lys Arg Val Val Leu Lys Ser Asp Thr Glu Gln Ser Glu
3905                3910                3915                3920
Asp Asn Asn Glu
                


<210> 7032
<211> 466
<212> PRT
<213> Homo sapiens

<400> 7032
Val His Ser Ser Met Gly Ala Pro Glu Ile Arg Met Ser Lys Pro Leu
 1               5                  10                  15      
Glu Ala Glu Lys Gln Gly Leu Asp Ser Pro Ser Glu His Thr Asp Thr
            20                  25                  30          
Glu Arg Asn Gly Pro Asp Thr Asn His Gln Asn Pro Gln Asn Lys Thr
        35                  40                  45              
Ser Pro Phe Ser Val Ser Pro Thr Gly Pro Ser Thr Lys Ile Lys Ala
    50                  55                  60                  
Glu Asp Pro Ser Gly Asp Ser Ala Pro Ala Ala Pro Leu Pro Pro Gln
65                  70                  75                  80  
Pro Ala Gln Pro His Leu Pro Gln Ala Gln Leu Met Leu Thr Gly Ser
                85                  90                  95      
Gln Leu Ala Gly Asp Ile Gln Gln Leu Leu Gln Leu Gln Gln Leu Val
            100                 105                 110         
Leu Val Pro Gly His His Leu Gln Pro Pro Ala Gln Phe Leu Leu Pro
        115                 120                 125             
Gln Ala Gln Gln Ser Gln Pro Gly Leu Leu Pro Thr Pro Asn Leu Phe
    130                 135                 140                 
Gln Leu Pro Gln Gln Thr Gln Gly Ala Leu Leu Thr Ser Gln Pro Arg
145                 150                 155                 160 
Ala Gly Leu Pro Thr Gln Ala Val Thr Arg Pro Thr Leu Pro Asp Pro
                165                 170                 175     
His Leu Ser His Pro Gln Pro Pro Lys Cys Leu Glu Pro Pro Ser His
            180                 185                 190         
Pro Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala Arg Thr
        195                 200                 205             
Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp Val Gly
    210                 215                 220                 
Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr Thr Ile
225                 230                 235                 240 
Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys Lys Leu
                245                 250                 255     
Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu Thr Met Ser Val
            260                 265                 270         
Asp Ser Ser Leu Pro Ser Pro Asn Gln Leu Ser Ser Pro Ser Leu Gly
        275                 280                 285             
Phe Asp Gly Leu Pro Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu
    290                 295                 300                 
Thr Asn Val Arg Phe Ala Leu Glu Lys Ser Phe Leu Ala Asn Gln Lys
305                 310                 315                 320 
Pro Thr Ser Glu Glu Ile Leu Leu Ile Ala Glu Gln Leu His Met Glu
                325                 330                 335     
Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys
            340                 345                 350         
Arg Ile Asn Pro Cys Ser Ala Ala Pro Met Leu Pro Ser Pro Gly Lys
        355                 360                 365             
Pro Ala Ser Tyr Ser Pro His Met Val Thr Pro Gln Gly Gly Ala Gly
    370                 375                 380                 
Thr Leu Pro Leu Ser Gln Ala Ser Ser Ser Leu Ser Thr Thr Val Thr
385                 390                 395                 400 
Thr Leu Ser Ser Ala Val Gly Thr Leu His Pro Ser Arg Thr Ala Gly
                405                 410                 415     
Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Pro Leu Asn Ser Ile Pro
            420                 425                 430         
Ser Val Thr Pro Pro Pro Pro Ala Thr Thr Asn Ser Thr Asn Pro Ser
        435                 440                 445             
Pro Gln Gly Ser His Ser Ala Ile Gly Leu Ser Gly Leu Asn Pro Ser
    450                 455                 460                 
Thr Gly
465     


<210> 7033
<211> 463
<212> PRT
<213> Homo sapiens

<400> 7033
Met Val His Ser Ser Met Gly Ala Pro Glu Ile Arg Met Ser Lys Pro
 1               5                  10                  15      
Leu Glu Ala Glu Lys Gln Gly Leu Asp Ser Pro Ser Glu His Thr Asp
            20                  25                  30          
Thr Glu Arg Asn Gly Pro Asp Thr Asn His Gln Asn Pro Gln Asn Lys
        35                  40                  45              
Thr Ser Pro Phe Ser Val Ser Pro Thr Gly Pro Ser Thr Lys Ile Lys
    50                  55                  60                  
Ala Glu Asp Pro Ser Gly Asp Ser Ala Pro Ala Ala Pro Leu Pro Pro
65                  70                  75                  80  
Gln Pro Ala Gln Pro His Leu Pro Gln Ala Gln Leu Met Leu Thr Gly
                85                  90                  95      
Ser Gln Leu Ala Gly Asp Ile Gln Gln Leu Leu Gln Leu Gln Gln Leu
            100                 105                 110         
Val Leu Val Pro Gly His His Leu Gln Pro Pro Ala Gln Phe Leu Leu
        115                 120                 125             
Pro Gln Ala Gln Gln Ser Gln Pro Gly Leu Leu Pro Thr Pro Asn Leu
    130                 135                 140                 
Phe Gln Leu Pro Gln Gln Thr Gln Gly Ala Leu Leu Thr Ser Gln Pro
145                 150                 155                 160 
Arg Ala Gly Leu Pro Thr Gln Pro Pro Lys Cys Leu Glu Pro Pro Ser
                165                 170                 175     
His Pro Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala Arg
            180                 185                 190         
Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp Val
        195                 200                 205             
Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr Thr
    210                 215                 220                 
Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys Lys
225                 230                 235                 240 
Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu Thr Met Ser
                245                 250                 255     
Val Asp Ser Ser Leu Pro Ser Pro Asn Gln Leu Ser Ser Pro Ser Leu
            260                 265                 270         
Gly Phe Asp Gly Leu Pro Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile
        275                 280                 285             
Glu Thr Asn Val Arg Phe Ala Leu Glu Lys Ser Phe Leu Ala Asn Gln
    290                 295                 300                 
Lys Pro Thr Ser Glu Glu Ile Leu Leu Ile Ala Glu Gln Leu His Met
305                 310                 315                 320 
Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu
                325                 330                 335     
Lys Arg Ile Asn Pro Cys Ser Ala Ala Pro Met Leu Pro Ser Pro Gly
            340                 345                 350         
Lys Pro Ala Ser Tyr Ser Pro His Met Val Thr Pro Gln Gly Gly Ala
        355                 360                 365             
Gly Thr Leu Pro Leu Ser Gln Ala Ser Ser Ser Leu Ser Thr Thr Val
    370                 375                 380                 
Thr Thr Leu Ser Ser Ala Val Gly Thr Leu His Pro Ser Arg Thr Ala
385                 390                 395                 400 
Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Pro Leu Asn Ser Ile
                405                 410                 415     
Pro Ser Val Thr Pro Pro Pro Pro Ala Thr Thr Asn Ser Thr Asn Pro
            420                 425                 430         
Ser Pro Gln Gly Ser His Ser Ala Ile Gly Leu Ser Gly Leu Asn Pro
        435                 440                 445             
Ser Thr Gly Pro Gly Leu Trp Trp Asn Pro Ala Pro Tyr Gln Pro
    450                 455                 460             


<210> 7034
<211> 478
<212> PRT
<213> Homo sapiens

<400> 7034
Val His Ser Ser Met Gly Ala Pro Glu Ile Arg Met Ser Lys Pro Leu
 1               5                  10                  15      
Glu Ala Glu Lys Gln Gly Leu Asp Ser Pro Ser Glu His Thr Asp Thr
            20                  25                  30          
Glu Arg Asn Gly Pro Asp Thr Asn His Gln Asn Pro Gln Asn Lys Thr
        35                  40                  45              
Ser Pro Phe Ser Val Ser Pro Thr Gly Pro Ser Thr Lys Ile Lys Ala
    50                  55                  60                  
Glu Asp Pro Ser Gly Asp Ser Ala Pro Ala Ala Pro Leu Pro Pro Gln
65                  70                  75                  80  
Pro Ala Gln Pro His Leu Pro Gln Ala Gln Leu Met Leu Thr Gly Ser
                85                  90                  95      
Gln Leu Ala Gly Asp Ile Gln Gln Leu Leu Gln Leu Gln Gln Leu Val
            100                 105                 110         
Leu Val Pro Gly His His Leu Gln Pro Pro Ala Gln Phe Leu Leu Pro
        115                 120                 125             
Gln Ala Gln Gln Ser Gln Pro Gly Leu Leu Pro Thr Pro Asn Leu Phe
    130                 135                 140                 
Gln Leu Pro Gln Gln Thr Gln Gly Ala Leu Leu Thr Ser Gln Pro Arg
145                 150                 155                 160 
Ala Gly Leu Pro Thr Gln Ala Val Thr Arg Pro Thr Leu Pro Asp Pro
                165                 170                 175     
His Leu Ser His Pro Gln Pro Pro Lys Cys Leu Glu Pro Pro Ser His
            180                 185                 190         
Pro Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala Arg Thr
        195                 200                 205             
Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp Val Gly
    210                 215                 220                 
Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr Thr Ile
225                 230                 235                 240 
Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys Lys Leu
                245                 250                 255     
Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu Thr Met Ser Val
            260                 265                 270         
Asp Ser Ser Leu Pro Ser Pro Asn Gln Leu Ser Ser Pro Ser Leu Gly
        275                 280                 285             
Phe Asp Gly Leu Pro Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu
    290                 295                 300                 
Thr Asn Val Arg Phe Ala Leu Glu Lys Ser Phe Leu Ala Asn Gln Lys
305                 310                 315                 320 
Pro Thr Ser Glu Glu Ile Leu Leu Ile Ala Glu Gln Leu His Met Glu
                325                 330                 335     
Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys
            340                 345                 350         
Arg Ile Asn Pro Cys Ser Ala Ala Pro Met Leu Pro Ser Pro Gly Lys
        355                 360                 365             
Pro Ala Ser Tyr Ser Pro His Met Val Thr Pro Gln Gly Gly Ala Gly
    370                 375                 380                 
Thr Leu Pro Leu Ser Gln Ala Ser Ser Ser Leu Ser Thr Thr Val Thr
385                 390                 395                 400 
Thr Leu Ser Ser Ala Val Gly Thr Leu His Pro Ser Arg Thr Ala Gly
                405                 410                 415     
Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Pro Leu Asn Ser Ile Pro
            420                 425                 430         
Ser Val Thr Pro Pro Pro Pro Ala Thr Thr Asn Ser Thr Asn Pro Ser
        435                 440                 445             
Pro Gln Gly Ser His Ser Ala Ile Gly Leu Ser Gly Leu Asn Pro Ser
    450                 455                 460                 
Thr Gly Pro Gly Leu Trp Trp Asn Pro Ala Pro Tyr Gln Pro
465                 470                 475             


<210> 7035
<211> 914
<212> PRT
<213> Homo sapiens

<400> 7035
Met Ser Gln Ser Gln Asn Ala Ile Phe Thr Ser Pro Thr Gly Glu Glu
 1               5                  10                  15      
Asn Leu Met Asn Ser Asn His Arg Asp Ser Glu Ser Ile Thr Asp Val
            20                  25                  30          
Cys Ser Asn Glu Asp Leu Pro Glu Val Glu Leu Val Ser Leu Leu Glu
        35                  40                  45              
Glu Gln Leu Pro Gln Tyr Arg Leu Lys Val Asp Thr Leu Phe Leu Tyr
    50                  55                  60                  
Glu Asn Gln Asp Trp Thr Gln Ser Pro His Gln Arg Gln His Ala Ser
65                  70                  75                  80  
Asp Ala Leu Ser Pro Val Leu Ala Glu Glu Thr Phe Arg Tyr Met Ile
                85                  90                  95      
Leu Gly Thr Asp Arg Val Glu Gln Met Thr Lys Thr Tyr Asn Asp Ile
            100                 105                 110         
Asp Met Val Thr His Leu Leu Ala Glu Arg Asp Arg Asp Leu Glu Leu
        115                 120                 125             
Ala Ala Arg Ile Gly Gln Ala Leu Leu Lys Arg Asn His Val Leu Ser
    130                 135                 140                 
Glu Gln Asn Glu Ser Leu Glu Glu Gln Leu Gly Gln Ala Phe Asp Gln
145                 150                 155                 160 
Val Asn Gln Leu Gln His Glu Leu Cys Lys Lys Asp Glu Leu Leu Arg
                165                 170                 175     
Ile Val Ser Ile Ala Ser Glu Glu Ser Glu Thr Asp Ser Ser Cys Ser
            180                 185                 190         
Thr Pro Leu Arg Phe Asn Glu Ser Phe Ser Leu Ser Gln Gly Leu Leu
        195                 200                 205             
Gln Leu Glu Met Leu Gln Glu Lys Leu Lys Glu Leu Glu Glu Glu Asn
    210                 215                 220                 
Met Ala Leu Arg Ser Lys Ala Cys His Ile Lys Thr Glu Thr Val Thr
225                 230                 235                 240 
Tyr Glu Glu Lys Glu Gln Gln Leu Val Ser Asp Cys Val Lys Glu Leu
                245                 250                 255     
Arg Glu Thr Asn Ala Gln Met Ser Arg Met Thr Glu Glu Leu Ser Gly
            260                 265                 270         
Lys Ser Asp Glu Leu Ile Arg Tyr Gln Glu Glu Leu Ser Ser Leu Leu
        275                 280                 285             
Ser Gln Ile Val Asp Leu Gln His Lys Leu Lys Glu His Val Ile Glu
    290                 295                 300                 
Lys Glu Glu Leu Lys Leu His Leu Gln Ala Ser Lys Asp Ala Gln Arg
305                 310                 315                 320 
Gln Leu Thr Met Glu Leu His Glu Leu Gln Asp Arg Asn Met Glu Cys
                325                 330                 335     
Leu Gly Met Leu His Glu Ser Gln Glu Glu Ile Lys Glu Leu Arg Ser
            340                 345                 350         
Arg Ser Gly Pro Thr Ala His Leu Tyr Phe Ser Gln Ser Tyr Gly Ala
        355                 360                 365             
Phe Thr Gly Glu Ser Leu Ala Ala Glu Ile Glu Gly Thr Met Arg Lys
    370                 375                 380                 
Lys Leu Ser Leu Asp Glu Glu Ser Ser Leu Phe Lys Gln Lys Ala Gln
385                 390                 395                 400 
Gln Lys Arg Val Phe Asp Thr Val Arg Ile Ala Asn Asp Thr Arg Gly
                405                 410                 415     
Arg Ser Ile Ser Phe Pro Ala Leu Leu Pro Ile Pro Gly Ser Asn Arg
            420                 425                 430         
Ser Ser Val Ile Met Thr Ala Lys Pro Phe Glu Ser Gly Leu Gln Gln
        435                 440                 445             
Thr Glu Asp Lys Ser Leu Leu Asn Gln Gly Ser Ser Ser Glu Glu Val
    450                 455                 460                 
Ala Gly Ser Ser Gln Lys Met Gly Gln Pro Gly Pro Ser Gly Asp Ser
465                 470                 475                 480 
Asp Leu Ala Thr Ala Leu His Arg Leu Ser Leu Arg Arg Gln Asn Tyr
                485                 490                 495     
Leu Ser Glu Lys Gln Phe Phe Ala Glu Glu Trp Gln Arg Lys Ile Gln
            500                 505                 510         
Val Leu Ala Asp Gln Lys Glu Gly Val Ser Gly Cys Val Thr Pro Thr
        515                 520                 525             
Glu Ser Leu Ala Ser Leu Cys Thr Thr Gln Ser Glu Ile Thr Asp Leu
    530                 535                 540                 
Ser Ser Ala Ser Cys Leu Arg Gly Phe Met Pro Glu Lys Leu Gln Ile
545                 550                 555                 560 
Val Lys Pro Leu Glu Gly Ser Gln Thr Leu Tyr His Trp Gln Gln Leu
                565                 570                 575     
Ala Gln Pro Asn Leu Gly Thr Ile Leu Asp Pro Arg Pro Gly Val Ile
            580                 585                 590         
Thr Lys Gly Phe Thr Gln Leu Pro Gly Asp Ala Ile Tyr His Ile Ser
        595                 600                 605             
Asp Leu Glu Glu Asp Glu Glu Glu Gly Ile Thr Phe Gln Val Gln Gln
    610                 615                 620                 
Pro Leu Glu Val Glu Glu Lys Leu Ser Thr Ser Lys Pro Val Thr Gly
625                 630                 635                 640 
Ile Phe Leu Pro Pro Ile Thr Ser Ala Gly Gly Pro Val Thr Val Ala
                645                 650                 655     
Thr Ala Asn Pro Gly Lys Cys Leu Ser Cys Thr Asn Ser Thr Phe Thr
            660                 665                 670         
Phe Thr Thr Cys Arg Ile Leu His Pro Ser Asp Ile Thr Gln Val Thr
        675                 680                 685             
Pro Ser Ser Gly Phe Pro Ser Leu Ser Cys Gly Ser Ser Gly Ser Ser
    690                 695                 700                 
Ser Ser Asn Thr Ala Val Asn Ser Pro Ala Leu Ser Tyr Arg Leu Ser
705                 710                 715                 720 
Ile Gly Glu Ser Ile Thr Asn Arg Arg Asp Ser Thr Thr Thr Phe Ser
                725                 730                 735     
Ser Thr Met Ser Leu Ala Lys Leu Leu Gln Glu Arg Gly Ile Ser Ala
            740                 745                 750         
Lys Val Tyr His Ser Pro Ile Ser Glu Asn Pro Leu Gln Pro Leu Pro
        755                 760                 765             
Lys Ser Leu Ala Ile Pro Ser Thr Pro Pro Asn Ser Pro Ser His Ser
    770                 775                 780                 
Pro Cys Pro Ser Pro Leu Pro Phe Glu Pro Arg Val His Leu Ser Glu
785                 790                 795                 800 
Asn Phe Leu Ala Ser Arg Pro Ala Glu Thr Phe Leu Gln Glu Met Tyr
                805                 810                 815     
Gly Leu Arg Pro Ser Arg Asn Pro Pro Asp Val Gly Gln Leu Lys Met
            820                 825                 830         
Asn Leu Val Asp Arg Leu Lys Arg Leu Gly Ile Ala Arg Val Val Lys
        835                 840                 845             
Asn Pro Gly Ala Gln Glu Asn Gly Arg Cys Gln Glu Ala Glu Ile Gly
    850                 855                 860                 
Pro Gln Lys Pro Asp Ser Ala Val Tyr Leu Asn Ser Gly Ser Ser Leu
865                 870                 875                 880 
Leu Gly Gly Leu Arg Arg Asn Gln Ser Leu Pro Val Ile Met Gly Ser
                885                 890                 895     
Phe Ala Ala Pro Val Cys Thr Ser Ser Pro Lys Met Gly Val Leu Lys
            900                 905                 910         
Glu Asp
        


<210> 7036
<211> 260
<212> PRT
<213> Homo sapiens

<400> 7036
Met Met Asp Pro Cys Ser Val Gly Val Gln Leu Arg Thr Thr Asn Glu
 1               5                  10                  15      
Cys His Lys Thr Tyr Tyr Thr Arg His Thr Gly Phe Lys Thr Leu Gln
            20                  25                  30          
Glu Leu Ser Ser Asn Asp Met Leu Leu Leu Gln Leu Arg Thr Gly Met
        35                  40                  45              
Thr Leu Ser Gly Asn Asn Thr Ile Cys Phe His His Val Lys Ile Tyr
    50                  55                  60                  
Ile Asp Arg Phe Glu Asp Leu Gln Lys Ser Cys Cys Asp Pro Phe Asn
65                  70                  75                  80  
Ile His Lys Lys Leu Ala Lys Lys Asn Leu His Val Ile Asp Leu Asp
                85                  90                  95      
Asp Ala Thr Phe Leu Ser Ala Lys Phe Gly Arg Gln Leu Val Pro Gly
            100                 105                 110         
Trp Lys Leu Cys Pro Lys Cys Thr Gln Ile Ile Asn Gly Ser Val Asp
        115                 120                 125             
Val Asp Thr Glu Asp Arg Gln Lys Arg Lys Pro Glu Ser Asp Gly Arg
    130                 135                 140                 
Thr Ala Lys Ala Leu Arg Ser Leu Gln Phe Thr Asn Pro Gly Arg Gln
145                 150                 155                 160 
Thr Glu Phe Ala Pro Glu Thr Gly Lys Arg Glu Lys Arg Arg Leu Thr
                165                 170                 175     
Lys Asn Ala Thr Ala Gly Ser Asp Arg Gln Val Ile Pro Ala Lys Ser
            180                 185                 190         
Lys Val Tyr Asp Ser Gln Gly Leu Leu Ile Phe Ser Gly Met Asp Leu
        195                 200                 205             
Cys Asp Cys Leu Asp Glu Asp Cys Leu Gly Cys Phe Tyr Ala Cys Pro
    210                 215                 220                 
Ala Cys Gly Ser Thr Lys Cys Gly Ala Glu Cys Arg Cys Asp Arg Lys
225                 230                 235                 240 
Trp Leu Tyr Glu Gln Ile Glu Ile Glu Gly Gly Glu Ile Ile His Asn
                245                 250                 255     
Lys His Ala Gly
            260 


<210> 7037
<211> 848
<212> PRT
<213> Homo sapiens

<400> 7037
Met Ala Lys Pro Leu Thr Asp Gln Glu Lys Arg Arg Gln Ile Ser Ile
 1               5                  10                  15      
Arg Gly Ile Val Gly Val Glu Asn Val Ala Glu Leu Lys Lys Ser Phe
            20                  25                  30          
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr
        35                  40                  45              
Thr Arg Asp Tyr Tyr Phe Ala Leu Ala His Thr Val Arg Asp His Leu
    50                  55                  60                  
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Asp Lys Cys Pro
65                  70                  75                  80  
Lys Arg Val Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu
                85                  90                  95      
Gln Asn Thr Met Ile Asn Leu Gly Leu Gln Asn Ala Cys Asp Glu Ala
            100                 105                 110         
Ile Tyr Gln Leu Gly Leu Asp Ile Glu Glu Leu Glu Glu Ile Glu Glu
        115                 120                 125             
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe
    130                 135                 140                 
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile
145                 150                 155                 160 
Arg Tyr Glu Tyr Gly Ile Phe Asn Gln Lys Ile Arg Asp Gly Trp Gln
                165                 170                 175     
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys
            180                 185                 190         
Ser Arg Pro Glu Phe Met Leu Pro Val His Phe Tyr Gly Lys Val Glu
        195                 200                 205             
His Thr Asn Thr Gly Thr Lys Trp Ile Asp Thr Gln Val Val Leu Ala
    210                 215                 220                 
Leu Pro Tyr Asp Thr Pro Val Pro Gly Tyr Met Asn Asn Thr Val Asn
225                 230                 235                 240 
Thr Met Arg Leu Trp Ser Ala Arg Ala Pro Asn Asp Phe Asn Leu Arg
                245                 250                 255     
Asp Phe Asn Val Gly Asp Tyr Ile Gln Ala Val Leu Asp Arg Asn Leu
            260                 265                 270         
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu
        275                 280                 285             
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr
    290                 295                 300                 
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ala Ser Lys Phe Gly Ser Thr
305                 310                 315                 320 
Arg Gly Ala Gly Thr Val Phe Asp Ala Phe Pro Asp Gln Ala Ser Ala
                325                 330                 335     
Ile Gln Leu Asn Asp Thr His Pro Ala Leu Ala Ile Pro Glu Leu Met
            340                 345                 350         
Arg Ile Phe Val Asp Ile Glu Lys Leu Pro Trp Ser Lys Ala Trp Glu
        355                 360                 365             
Leu Thr Gln Lys Thr Phe Ala Tyr Thr Asn His Thr Val Leu Pro Glu
    370                 375                 380                 
Ala Leu Glu Arg Trp Pro Val Asp Leu Val Glu Lys Leu Leu Pro Arg
385                 390                 395                 400 
His Leu Glu Ile Ile Tyr Glu Ile Asn Gln Lys His Leu Asp Arg Ile
                405                 410                 415     
Val Ala Leu Phe Pro Lys Asp Val Asp Arg Leu Arg Arg Met Ser Leu
            420                 425                 430         
Ile Glu Glu Glu Gly Ser Lys Arg Ile Asn Met Ala His Leu Cys Ile
        435                 440                 445             
Val Gly Ser His Ala Val Asn Gly Val Ala Lys Ile His Ser Asp Ile
    450                 455                 460                 
Val Lys Thr Lys Val Phe Lys Asp Phe Ser Glu Leu Glu Pro Asp Lys
465                 470                 475                 480 
Phe Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu
                485                 490                 495     
Cys Asn Pro Gly Leu Ala Glu Leu Ile Ala Glu Lys Ile Gly Glu Asp
            500                 505                 510         
Tyr Val Lys Asp Leu Ser Gln Leu Thr Lys Leu His Ser Phe Leu Gly
        515                 520                 525             
Asp Asp Val Phe Leu Arg Glu Leu Ala Lys Val Lys Gln Glu Asn Lys
    530                 535                 540                 
Leu Lys Phe Ser Gln Phe Leu Glu Thr Glu Tyr Lys Val Lys Ile Asn
545                 550                 555                 560 
Pro Ser Ser Met Phe Asp Val Gln Val Lys Arg Ile His Glu Tyr Lys
                565                 570                 575     
Arg Gln Leu Leu Asn Cys Leu His Val Ile Thr Met Tyr Asn Arg Ile
            580                 585                 590         
Lys Lys Asp Pro Lys Lys Leu Phe Val Pro Arg Thr Val Ile Ile Gly
        595                 600                 605             
Gly Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Lys Leu
    610                 615                 620                 
Ile Thr Ser Val Ala Asp Val Val Asn Asn Asp Pro Met Val Gly Ser
625                 630                 635                 640 
Lys Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu
                645                 650                 655     
Lys Val Ile Pro Ala Thr Asp Leu Ser Glu Gln Ile Ser Thr Ala Gly
            660                 665                 670         
Thr Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala
        675                 680                 685             
Leu Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu
    690                 695                 700                 
Ala Gly Glu Glu Asn Leu Phe Ile Phe Gly Met Arg Ile Asp Asp Val
705                 710                 715                 720 
Ala Ala Leu Asp Lys Lys Gly Tyr Glu Ala Lys Glu Tyr Tyr Glu Ala
                725                 730                 735     
Leu Pro Glu Leu Lys Leu Val Ile Asp Gln Ile Asp Asn Gly Phe Phe
            740                 745                 750         
Ser Pro Lys Gln Pro Asp Leu Phe Lys Asp Ile Ile Asn Met Leu Phe
        755                 760                 765             
Tyr His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Val Lys
    770                 775                 780                 
Cys Gln Asp Lys Val Ser Gln Leu Tyr Met Asn Pro Lys Ala Trp Asn
785                 790                 795                 800 
Thr Met Val Leu Lys Asn Ile Ala Ala Ser Gly Lys Phe Ser Ser Asp
                805                 810                 815     
Arg Thr Ile Lys Glu Tyr Ala Gln Asn Ile Trp Asn Val Glu Pro Ser
            820                 825                 830         
Asp Leu Lys Ile Ser Leu Ser Asn Glu Ser Asn Lys Val Asn Gly Asn
        835                 840                 845             


<210> 7038
<211> 1332
<212> PRT
<213> Homo sapiens

<400> 7038
Met Thr Gly Glu Val Gly Ser Glu Val His Leu Glu Ile Asn Asp Pro
 1               5                  10                  15      
Asn Val Ile Ser Gln Glu Glu Ala Asp Ser Pro Ser Asp Ser Gly Gln
            20                  25                  30          
Gly Ser Tyr Glu Thr Ile Gly Pro Leu Ser Glu Gly Asp Ser Asp Glu
        35                  40                  45              
Glu Ile Phe Val Ser Lys Lys Leu Lys Asn Arg Lys Val Leu Gln Asp
    50                  55                  60                  
Ser Asp Ser Glu Thr Glu Asp Thr Asn Ala Ser Pro Glu Lys Thr Thr
65                  70                  75                  80  
Tyr Asp Ser Ala Glu Glu Glu Asn Lys Glu Asn Leu Tyr Ala Gly Lys
                85                  90                  95      
Asn Thr Lys Ile Lys Arg Ile Tyr Lys Thr Val Ala Asp Ser Asp Glu
            100                 105                 110         
Ser Tyr Met Glu Lys Ser Leu Tyr Gln Glu Asn Leu Glu Ala Gln Val
        115                 120                 125             
Lys Pro Cys Leu Glu Leu Ser Leu Gln Ser Gly Asn Ser Thr Asp Phe
    130                 135                 140                 
Thr Thr Asp Arg Lys Ser Ser Lys Lys His Ile His Asp Lys Glu Gly
145                 150                 155                 160 
Thr Ala Gly Lys Ala Lys Val Lys Ser Lys Arg Arg Leu Glu Lys Glu
                165                 170                 175     
Glu Arg Lys Met Glu Lys Ile Arg Gln Leu Lys Lys Lys Glu Thr Lys
            180                 185                 190         
Asn Gln Glu Asp Asp Val Glu Gln Pro Phe Asn Asp Ser Gly Cys Leu
        195                 200                 205             
Leu Val Asp Lys Asp Leu Phe Glu Thr Gly Leu Glu Asp Glu Asn Asn
    210                 215                 220                 
Ser Pro Leu Glu Asp Glu Glu Ser Leu Glu Ser Ile Arg Ala Ala Val
225                 230                 235                 240 
Lys Asn Lys Val Lys Lys His Lys Lys Lys Glu Pro Ser Leu Glu Ser
                245                 250                 255     
Gly Val His Ser Phe Glu Glu Gly Ser Glu Leu Ser Lys Gly Thr Thr
            260                 265                 270         
Arg Lys Glu Arg Lys Ala Ala Arg Leu Ser Lys Glu Ala Leu Lys Gln
        275                 280                 285             
Leu His Ser Glu Thr Gln Arg Leu Ile Arg Glu Ser Ala Leu Asn Leu
    290                 295                 300                 
Pro Tyr His Met Pro Glu Asn Lys Thr Ile His Asp Phe Phe Lys Arg
305                 310                 315                 320 
Lys Pro Arg Pro Thr Cys His Gly Asn Ala Met Ala Leu Leu Lys Ser
                325                 330                 335     
Ser Lys Tyr Gln Ser Ser His His Lys Glu Ile Ile Asp Thr Ala Asn
            340                 345                 350         
Thr Thr Glu Met Asn Ser Asp His His Ser Lys Gly Ser Glu Gln Thr
        355                 360                 365             
Thr Gly Ala Glu Asn Glu Val Glu Thr Asn Ala Leu Pro Val Val Ser
    370                 375                 380                 
Lys Glu Thr Gln Ile Ile Thr Gly Ser Asp Glu Ser Cys Arg Lys Asp
385                 390                 395                 400 
Leu Val Lys Asn Glu Glu Leu Glu Ile Gln Glu Lys Gln Lys Gln Ser
                405                 410                 415     
Asp Ile Arg Pro Ser Pro Gly Asp Ser Ser Val Leu Gln Gln Glu Ser
            420                 425                 430         
Asn Phe Leu Gly Asn Asn His Ser Glu Glu Cys Gln Val Gly Gly Leu
        435                 440                 445             
Val Ala Phe Glu Pro His Ala Leu Glu Gly Glu Gly Pro Gln Asn Pro
    450                 455                 460                 
Glu Glu Thr Asp Glu Lys Val Glu Glu Pro Glu Gln Gln Asn Lys Ser
465                 470                 475                 480 
Ser Ala Val Gly Pro Pro Glu Lys Val Arg Arg Phe Thr Leu Asp Arg
                485                 490                 495     
Leu Lys Gln Leu Gly Val Asp Val Ser Ile Lys Pro Arg Leu Gly Ala
            500                 505                 510         
Asp Glu Asp Ser Phe Val Ile Leu Glu Pro Glu Thr Asn Arg Glu Leu
        515                 520                 525             
Glu Ala Leu Lys Gln Arg Phe Trp Lys His Ala Asn Pro Ala Ala Lys
    530                 535                 540                 
Pro Arg Ala Gly Gln Thr Val Asn Val Asn Val Ile Val Lys Asp Met
545                 550                 555                 560 
Gly Thr Asp Gly Lys Glu Glu Leu Lys Ala Asp Val Val Pro Val Thr
                565                 570                 575     
Leu Ala Pro Lys Lys Leu Asp Gly Ala Ser His Thr Lys Pro Gly Glu
            580                 585                 590         
Lys Leu Gln Val Leu Lys Ala Lys Leu Gln Glu Ala Met Lys Leu Arg
        595                 600                 605             
Arg Phe Glu Glu Arg Gln Lys Arg Gln Ala Leu Phe Lys Leu Asp Asn
    610                 615                 620                 
Glu Asp Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Met Thr Asp
625                 630                 635                 640 
Glu Ser Glu Glu Asp Gly Glu Glu Lys Val Glu Lys Glu Glu Lys Glu
                645                 650                 655     
Glu Glu Leu Glu Glu Glu Glu Gly Lys Glu Glu Glu Glu Glu Glu Glu
            660                 665                 670         
Gly Asn Gln Glu Thr Ala Glu Phe Leu Leu Ser Ser Glu Glu Ile Glu
        675                 680                 685             
Thr Lys Asp Glu Lys Glu Met Asp Lys Glu Asn Asn Asp Gly Ser Ser
    690                 695                 700                 
Glu Ile Gly Lys Ala Val Gly Phe Leu Ser Val Pro Lys Ser Leu Ser
705                 710                 715                 720 
Ser Asp Ser Thr Leu Leu Leu Phe Lys Asp Ser Ser Ser Lys Met Gly
                725                 730                 735     
Tyr Ser Pro Thr Glu Glu Lys Ser Glu Thr Asp Glu Asn Ser Gly Lys
            740                 745                 750         
Gln Pro Ser Lys Leu Asp Glu Asp Asp Ser Cys Ser Leu Leu Thr Lys
        755                 760                 765             
Glu Ser Ser His Asn Ser Ser Phe Glu Leu Ile Gly Ser Thr Ile Pro
    770                 775                 780                 
Ser Tyr Gln Pro Cys Asn Arg Gln Thr Gly Arg Gly Thr Ser Phe Phe
785                 790                 795                 800 
Pro Thr Ala Gly Gly Phe Arg Ser Pro Ser Pro Gly Leu Phe Arg Ala
                805                 810                 815     
Ser Leu Val Ser Ser Ala Ser Lys Ser Ser Gly Lys Leu Ser Glu Pro
            820                 825                 830         
Ser Leu Pro Ile Glu Asp Ser Gln Asp Leu Tyr Asn Ala Ser Pro Glu
        835                 840                 845             
Pro Lys Thr Leu Phe Leu Gly Ala Gly Asp Phe Gln Phe Cys Leu Glu
    850                 855                 860                 
Asp Asp Thr Gln Ser Gln Leu Leu Asp Ala Asp Gly Phe Leu Asn Val
865                 870                 875                 880 
Arg Asn His Arg Asn Gln Tyr Gln Ala Leu Lys Pro Arg Leu Pro Leu
                885                 890                 895     
Ala Ser Met Asp Glu Asn Ala Met Asp Ala Asn Met Asp Glu Leu Leu
            900                 905                 910         
Asp Leu Cys Thr Gly Lys Phe Thr Ser Gln Ala Glu Lys His Leu Pro
        915                 920                 925             
Arg Lys Ser Asp Lys Lys Glu Asn Met Glu Glu Leu Leu Asn Leu Cys
    930                 935                 940                 
Ser Gly Lys Phe Thr Ser Gln Asp Ala Ser Thr Pro Ala Ser Ser Glu
945                 950                 955                 960 
Leu Asn Lys Gln Glu Lys Glu Ser Ser Met Gly Asp Pro Met Glu Glu
                965                 970                 975     
Ala Leu Ala Leu Cys Ser Gly Ser Phe Pro Thr Asp Lys Glu Glu Glu
            980                 985                 990         
Asp Glu Glu Glu Glu Phe Gly Asp Phe Arg Leu Val Ser Asn Asp Asn
        995                 1000                1005            
Glu Phe Asp Ser Asp Glu Asp Glu His Ser Asp Ser Gly Asn Asp Leu
    1010                1015                1020                
Ala Leu Glu Asp His Glu Asp Asp Asp Glu Glu Glu Leu Leu Lys Arg
1025                1030                1035                1040
Ser Glu Lys Leu Lys Arg Gln Met Arg Leu Arg Lys Tyr Leu Glu Asp
                1045                1050                1055    
Glu Ala Glu Val Ser Gly Ser Asp Val Gly Ser Glu Asp Glu Tyr Asp
            1060                1065                1070        
Gly Glu Glu Ile Asp Glu Tyr Glu Glu Asp Val Ile Asp Glu Val Leu
        1075                1080                1085            
Pro Ser Asp Glu Glu Leu Gln Ser Gln Ile Lys Lys Ile His Met Lys
    1090                1095                1100                
Thr Met Leu Asp Asp Asp Lys Arg Gln Leu Arg Leu Tyr Gln Glu Arg
1105                1110                1115                1120
Tyr Leu Ala Asp Gly Asp Leu His Ser Asp Gly Pro Gly Arg Met Arg
                1125                1130                1135    
Lys Phe Arg Trp Lys Asn Ile Asp Asp Ala Ser Gln Met Asp Leu Phe
            1140                1145                1150        
His Arg Asp Ser Asp Asp Asp Gln Thr Glu Glu Gln Leu Asp Glu Ser
        1155                1160                1165            
Glu Ala Arg Trp Arg Lys Glu Arg Ile Glu Arg Glu Gln Trp Leu Arg
    1170                1175                1180                
Asp Met Ala Gln Gln Gly Lys Ile Thr Ala Glu Glu Glu Glu Glu Ile
1185                1190                1195                1200
Gly Glu Asp Ser Gln Phe Met Ile Leu Ala Lys Lys Val Thr Ala Lys
                1205                1210                1215    
Ala Leu Gln Lys Asn Ala Ser Arg Pro Met Val Ile Gln Glu Ser Lys
            1220                1225                1230        
Ser Leu Leu Arg Asn Pro Phe Glu Ala Ile Arg Pro Gly Ser Ala Gln
        1235                1240                1245            
Gln Val Lys Thr Gly Ser Leu Leu Asn Gln Pro Lys Ala Val Leu Gln
    1250                1255                1260                
Lys Leu Ala Ala Leu Ser Asp His Asn Pro Ser Ala Pro Arg Asn Ser
1265                1270                1275                1280
Arg Asn Phe Val Phe His Thr Leu Ser Pro Val Lys Ala Glu Ala Ala
                1285                1290                1295    
Lys Glu Ser Ser Lys Ser Gln Lys Ile Pro Glu Lys Asp Ser Asp Trp
            1300                1305                1310        
Leu Thr Trp Ser Gly Ala Pro Ile Pro Gly Phe Phe Arg Leu Ser Phe
        1315                1320                1325            
Asp Pro His Gly
    1330        


<210> 7039
<211> 1339
<212> PRT
<213> Homo sapiens

<400> 7039
Met Thr Gly Glu Val Gly Ser Glu Val His Leu Glu Ile Asn Asp Pro
 1               5                  10                  15      
Asn Val Ile Ser Gln Glu Glu Ala Asp Ser Pro Ser Asp Ser Gly Gln
            20                  25                  30          
Gly Ser Tyr Glu Thr Ile Gly Pro Leu Ser Glu Gly Asp Ser Asp Glu
        35                  40                  45              
Glu Ile Phe Val Ser Lys Lys Leu Lys Asn Arg Lys Val Leu Gln Asp
    50                  55                  60                  
Ser Asp Ser Glu Thr Glu Asp Thr Asn Ala Ser Pro Glu Lys Thr Thr
65                  70                  75                  80  
Tyr Asp Ser Ala Glu Glu Glu Asn Lys Glu Asn Leu Tyr Ala Gly Lys
                85                  90                  95      
Asn Thr Lys Ile Lys Arg Ile Tyr Lys Thr Val Ala Asp Ser Asp Glu
            100                 105                 110         
Ser Tyr Met Glu Lys Ser Leu Tyr Gln Glu Asn Leu Glu Ala Gln Val
        115                 120                 125             
Lys Pro Cys Leu Glu Leu Ser Leu Gln Ser Gly Asn Ser Thr Asp Phe
    130                 135                 140                 
Thr Thr Asp Arg Lys Ser Ser Lys Lys His Ile His Asp Lys Glu Gly
145                 150                 155                 160 
Thr Ala Gly Lys Ala Lys Val Lys Ser Lys Arg Arg Leu Glu Lys Glu
                165                 170                 175     
Glu Arg Lys Met Glu Lys Ile Arg Gln Leu Lys Lys Lys Glu Thr Lys
            180                 185                 190         
Asn Gln Glu Asp Asp Val Glu Gln Pro Phe Asn Asp Ser Gly Cys Leu
        195                 200                 205             
Leu Val Asp Lys Asp Leu Phe Glu Thr Gly Leu Glu Asp Glu Asn Asn
    210                 215                 220                 
Ser Pro Leu Glu Asp Glu Glu Ser Leu Glu Ser Ile Arg Ala Ala Val
225                 230                 235                 240 
Lys Asn Lys Val Lys Lys His Lys Lys Lys Glu Pro Ser Leu Glu Ser
                245                 250                 255     
Gly Val His Ser Phe Glu Glu Gly Ser Glu Leu Ser Lys Gly Thr Thr
            260                 265                 270         
Arg Lys Glu Arg Lys Ala Ala Arg Leu Ser Lys Glu Ala Leu Lys Gln
        275                 280                 285             
Leu His Ser Glu Thr Gln Arg Leu Ile Arg Glu Ser Ala Leu Asn Leu
    290                 295                 300                 
Pro Tyr His Met Pro Glu Asn Lys Thr Ile His Asp Phe Phe Lys Arg
305                 310                 315                 320 
Lys Pro Arg Pro Thr Cys His Gly Asn Ala Met Ala Leu Leu Lys Ser
                325                 330                 335     
Ser Lys Tyr Gln Ser Ser His His Lys Glu Ile Ile Asp Thr Ala Asn
            340                 345                 350         
Thr Thr Glu Met Asn Ser Asp His His Ser Lys Gly Ser Glu Gln Thr
        355                 360                 365             
Thr Gly Ala Glu Asn Glu Val Glu Thr Asn Ala Leu Pro Val Val Ser
    370                 375                 380                 
Lys Glu Thr Gln Ile Ile Thr Gly Ser Asp Glu Ser Cys Arg Lys Asp
385                 390                 395                 400 
Leu Val Lys Asn Glu Glu Leu Glu Ile Gln Glu Lys Gln Lys Gln Ser
                405                 410                 415     
Asp Ile Arg Pro Ser Pro Gly Asp Ser Ser Val Leu Gln Gln Glu Ser
            420                 425                 430         
Asn Phe Leu Gly Asn Asn His Ser Glu Glu Cys Gln Val Gly Gly Leu
        435                 440                 445             
Val Ala Phe Glu Pro His Ala Leu Glu Gly Glu Gly Pro Gln Asn Pro
    450                 455                 460                 
Glu Glu Thr Asp Glu Lys Val Glu Glu Pro Glu Gln Gln Asn Lys Ser
465                 470                 475                 480 
Ser Ala Val Gly Pro Pro Glu Lys Val Arg Arg Phe Thr Leu Asp Arg
                485                 490                 495     
Leu Lys Gln Leu Gly Val Asp Val Ser Ile Lys Pro Arg Leu Gly Ala
            500                 505                 510         
Asp Glu Asp Ser Phe Val Ile Leu Glu Pro Glu Thr Asn Arg Glu Leu
        515                 520                 525             
Glu Ala Leu Lys Gln Arg Phe Trp Lys His Ala Asn Pro Ala Ala Lys
    530                 535                 540                 
Pro Arg Ala Gly Gln Thr Val Asn Val Asn Val Ile Val Lys Asp Met
545                 550                 555                 560 
Gly Thr Asp Gly Lys Glu Glu Leu Lys Ala Asp Val Val Pro Val Thr
                565                 570                 575     
Leu Ala Pro Lys Lys Leu Asp Gly Ala Ser His Thr Lys Pro Gly Glu
            580                 585                 590         
Lys Leu Gln Val Leu Lys Ala Lys Leu Gln Glu Ala Met Lys Leu Arg
        595                 600                 605             
Arg Phe Glu Glu Arg Gln Lys Arg Gln Ala Leu Phe Lys Leu Asp Asn
    610                 615                 620                 
Glu Asp Gly Phe Glu Glu Glu Glu Glu Glu Glu Glu Glu Met Thr Asp
625                 630                 635                 640 
Glu Ser Glu Glu Asp Gly Glu Glu Lys Val Glu Lys Glu Glu Lys Glu
                645                 650                 655     
Glu Glu Leu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu
            660                 665                 670         
Gly Asn Gln Glu Thr Ala Glu Phe Leu Leu Ser Ser Glu Glu Ile Glu
        675                 680                 685             
Thr Lys Asp Glu Lys Glu Met Asp Lys Glu Asn Asn Asp Gly Ser Ser
    690                 695                 700                 
Glu Ile Gly Lys Ala Val Gly Phe Leu Ser Val Pro Lys Ser Leu Ser
705                 710                 715                 720 
Ser Asp Ser Thr Leu Leu Leu Phe Lys Asp Ser Ser Ser Lys Met Gly
                725                 730                 735     
Tyr Phe Pro Thr Glu Glu Lys Ser Glu Thr Asp Glu Asn Ser Gly Lys
            740                 745                 750         
Gln Pro Ser Lys Leu Asp Glu Asp Asp Ser Cys Ser Leu Leu Thr Lys
        755                 760                 765             
Glu Ser Ser His Asn Ser Ser Phe Glu Leu Ile Gly Ser Thr Ile Pro
    770                 775                 780                 
Ser Tyr Gln Pro Cys Asn Arg Gln Thr Gly Arg Gly Thr Ser Phe Phe
785                 790                 795                 800 
Pro Thr Ala Gly Gly Phe Arg Ser Pro Ser Pro Gly Leu Phe Arg Ala
                805                 810                 815     
Ser Leu Val Ser Ser Ala Ser Lys Ser Ser Gly Lys Leu Ser Glu Pro
            820                 825                 830         
Ser Leu Pro Ile Glu Asp Ser Gln Asp Leu Tyr Asn Ala Ser Pro Glu
        835                 840                 845             
Pro Lys Thr Leu Phe Leu Gly Ala Gly Asp Phe Gln Phe Cys Leu Glu
    850                 855                 860                 
Asp Asp Thr Gln Ser Gln Leu Leu Asp Ala Asp Gly Phe Leu Asn Val
865                 870                 875                 880 
Arg Asn His Arg Asn Gln Tyr Gln Ala Leu Lys Pro Arg Leu Pro Leu
                885                 890                 895     
Ala Ser Met Asp Glu Asn Ala Met Asp Ala Asn Met Asp Glu Leu Leu
            900                 905                 910         
Asp Leu Cys Thr Gly Lys Phe Thr Ser Gln Ala Glu Lys His Leu Pro
        915                 920                 925             
Arg Lys Ser Asp Lys Lys Glu Asn Met Glu Glu Leu Leu Asn Leu Cys
    930                 935                 940                 
Ser Gly Lys Phe Thr Ser Gln Asp Ala Ser Thr Pro Ala Ser Ser Glu
945                 950                 955                 960 
Leu Asn Lys Gln Glu Lys Glu Ser Ser Met Gly Asp Pro Met Glu Glu
                965                 970                 975     
Ala Leu Ala Leu Cys Ser Gly Ser Phe Pro Thr Asp Lys Glu Glu Glu
            980                 985                 990         
Asp Glu Glu Glu Glu Phe Gly Asp Phe Arg Leu Val Ser Asn Asp Asn
        995                 1000                1005            
Glu Phe Asp Ser Asp Glu Asp Glu His Ser Asp Ser Gly Asn Asp Leu
    1010                1015                1020                
Ala Leu Glu Asp His Glu Asp Asp Asp Glu Glu Glu Leu Leu Lys Arg
1025                1030                1035                1040
Ser Glu Lys Leu Lys Arg Gln Met Arg Leu Arg Lys Tyr Leu Glu Asp
                1045                1050                1055    
Glu Ala Glu Val Ser Gly Ser Asp Val Gly Ser Glu Asp Glu Tyr Asp
            1060                1065                1070        
Gly Glu Glu Ile Asp Glu Tyr Glu Glu Asp Val Ile Asp Glu Val Leu
        1075                1080                1085            
Pro Ser Asp Glu Glu Leu Gln Ser Gln Ile Lys Lys Ile His Met Lys
    1090                1095                1100                
Thr Met Leu Asp Asp Asp Lys Arg Gln Leu Arg Leu Tyr Gln Glu Arg
1105                1110                1115                1120
Tyr Leu Ala Asp Gly Asp Leu His Ser Asp Gly Pro Gly Arg Met Arg
                1125                1130                1135    
Lys Phe Arg Trp Lys Asn Ile Asp Asp Ala Ser Gln Met Asp Leu Phe
            1140                1145                1150        
His Arg Asp Ser Asp Asp Asp Gln Thr Glu Glu Gln Leu Asp Glu Ser
        1155                1160                1165            
Glu Ala Arg Trp Arg Lys Glu Arg Ile Glu Arg Glu Gln Trp Leu Arg
    1170                1175                1180                
Asp Met Ala Gln Gln Gly Lys Ile Thr Ala Glu Glu Glu Glu Glu Ile
1185                1190                1195                1200
Gly Glu Asp Ser Gln Phe Met Ile Leu Ala Lys Lys Val Thr Ala Lys
                1205                1210                1215    
Ala Leu Gln Lys Asn Ala Ser Arg Pro Met Val Ile Gln Glu Ser Lys
            1220                1225                1230        
Ser Leu Leu Arg Asn Pro Phe Glu Ala Ile Arg Pro Gly Ser Ala Gln
        1235                1240                1245            
Gln Val Lys Thr Gly Ser Leu Leu Asn Gln Pro Lys Ala Val Leu Gln
    1250                1255                1260                
Lys Leu Ala Ala Leu Ser Asp His Asn Pro Ser Ala Pro Arg Asn Ser
1265                1270                1275                1280
Arg Asn Phe Val Phe His Thr Leu Ser Pro Val Lys Ala Glu Ala Ala
                1285                1290                1295    
Lys Glu Ser Ser Lys Ser Gln Val Lys Lys Arg Gly Pro Ser Phe Met
            1300                1305                1310        
Thr Ser Pro Ser Pro Lys His Leu Lys Thr Asp Asp Ser Thr Ser Gly
        1315                1320                1325            
Leu Thr Arg Ser Ile Phe Lys Tyr Leu Glu Ser
    1330                1335                


<210> 7040
<211> 1631
<212> PRT
<213> Homo sapiens

<400> 7040
Leu Val Thr Pro Arg Val Leu Arg Val Gly Ser Pro Glu Ser Ile His
 1               5                  10                  15      
Ile Gln Ala His Ser Asp Ser Arg Gln Pro Leu Thr Arg Thr Leu Lys
            20                  25                  30          
Val Asn Leu Thr Val Trp Asp Phe Pro Met Arg Lys Thr Val Leu Ala
        35                  40                  45              
Arg Ser Gln Leu Ile Leu Ser Pro Gly Asn Asn Phe Met Asp Gln Ala
    50                  55                  60                  
Pro Val Thr Val Pro Glu Ser Leu Met Tyr Leu Pro Lys Pro Gly Gln
65                  70                  75                  80  
Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser Ser
                85                  90                  95      
Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile Phe
            100                 105                 110         
Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His Tyr
        115                 120                 125             
Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr Phe
    130                 135                 140                 
Thr Leu Asp Ile Lys Val Val Phe Pro Asp Glu Gly Cys Pro Cys Gln
145                 150                 155                 160 
Val Trp Glu Pro Glu Gly Trp Gln Arg Arg Leu Ser Phe Ser Val Ser
                165                 170                 175     
Ile Ser Leu Asn Phe Leu Cys Leu Ser Leu Gly Thr Trp Thr Ile Glu
            180                 185                 190         
Ala Ser Tyr Gln Ser Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp
        195                 200                 205             
Val Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Gln Leu Val Pro Asn
    210                 215                 220                 
Lys Thr Phe Phe Tyr Leu Lys Asp Glu Ala Leu Gly Val Asp Ile Gln
225                 230                 235                 240 
Ala Arg Gln Trp Asn Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn Lys
                245                 250                 255     
Pro Val Asp Gly His Ala Leu Val Ile Phe Gly Val Lys Leu Asp Ser
            260                 265                 270         
Cys Arg Ile Pro Ile Gln Ser Ser Leu Gln Arg Val Glu Ile Ser Glu
        275                 280                 285             
Gly Leu Gly His Val Ser Leu Gln Lys Asp Thr Leu Met Ala Ala Phe
    290                 295                 300                 
Gln Gly Pro Gly Glu Asp Phe Ile Gly Gly Ser Ile Phe Val Asn Val
305                 310                 315                 320 
Thr Met Phe Ser Ser Gly Gly Glu Met Val Gln Ala Glu Thr Ser Gly
                325                 330                 335     
Val Lys Ile Ile Gln Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro
            340                 345                 350         
Gln Tyr Phe Lys Pro Gly Met Pro Phe His Phe Arg Val Phe Ile Ser
        355                 360                 365             
Asn Pro Asp Gly Ser Pro Ala Ser Arg Val Leu Val His Ser Gln Asp
    370                 375                 380                 
Gln Lys Val Tyr Thr Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn
385                 390                 395                 400 
Thr Asp Ala Asn Leu Asp Lys Leu Pro Ile Glu Val Lys Thr Glu Glu
                405                 410                 415     
Ser Leu Gln Pro Glu Glu Gln Ala Ser Ala Lys Met Thr Ala Trp Pro
            420                 425                 430         
Tyr Leu Thr Gln Asp Gly Ser Gly Asn Phe Leu His Ile Glu Val Lys
        435                 440                 445             
Thr Leu Gly Thr Glu Val Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr
    450                 455                 460                 
Arg His Gln Asp Pro Lys Thr Lys Asp Lys Ile Thr His Phe Thr Ile
465                 470                 475                 480 
Leu Val Leu Ser Lys Gly Gln Thr Val Ser Ala Lys His Gln Ser Lys
                485                 490                 495     
Ser Gln Gly Ser Val Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser Ala
            500                 505                 510         
Met Leu Pro Ser Phe Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly
        515                 520                 525             
Ala Ser Gln Asp Pro Glu Leu Val Ala Asp Ser Ile Trp Ile Asp Val
    530                 535                 540                 
Asn Asp Arg Cys Ile Gly Met Leu Lys Val Gly Leu Lys Asn Asp Arg
545                 550                 555                 560 
Phe Phe Gln Ser Leu Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr
                565                 570                 575     
Gly Asp Ala Glu Ala Thr Val Gly Leu Val Ala Val Asp Lys Ala Val
            580                 585                 590         
Tyr Val Leu Asn Ser Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn
        595                 600                 605             
Val Val Glu Glu His Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp
    610                 615                 620                 
Arg Phe Ala Val Phe Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr
625                 630                 635                 640 
Gly Met Asp Ser Leu Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly
                645                 650                 655     
Lys Arg Arg Ala Glu Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln
            660                 665                 670         
Lys Cys Cys Glu Ala Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys
        675                 680                 685             
Glu Glu Arg Thr Trp His Val Arg His Gly Pro Ala Cys Val Ala Ala
    690                 695                 700                 
Phe Leu Asp Cys Cys His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg
705                 710                 715                 720 
Glu Asp Gln Leu His Leu Trp Thr Lys Asp Phe Asp Asp Leu Phe Leu
                725                 730                 735     
Asp Asp Met Pro Val Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp Arg
            740                 745                 750         
Lys Phe Thr Leu Pro Lys Ser Lys Ser Gly Ile Ser His Tyr Pro Ile
        755                 760                 765             
Ser Val Lys Val Pro Asp Ser Ile Thr Thr Trp Gln Phe Val Val Val
    770                 775                 780                 
Ser Leu Lys Ala Gly Gln Gly Leu Cys Val Ser Asp Pro Phe Glu Leu
785                 790                 795                 800 
Thr Val Met Lys Ser Phe Phe Val Asp Leu Lys Leu Pro Ser Ser Val
                805                 810                 815     
Ile Arg Asn Glu Gln Val Gln Ile Gln Ala Met Leu Tyr Asn Phe Arg
            820                 825                 830         
Asp Arg Gln Ala Lys Val Arg Val Glu Phe Pro His Lys Glu Thr Leu
        835                 840                 845             
Cys Ser Ala Ser Lys Pro Gly Ala Pro Ser His Gln Val Val Val Val
    850                 855                 860                 
Pro Pro Thr Ser Ser Lys Ile Val His Phe Val Leu Leu Pro Leu Glu
865                 870                 875                 880 
Thr Gly Lys Val Asp Val Glu Val Lys Ala Val Gly Tyr Gly Val Gln
                885                 890                 895     
Asp His Val Lys Lys Thr Leu Leu Val Arg Val Met Gly Thr Pro Asn
            900                 905                 910         
Ser Leu Ala Ala Gly Gln Thr Gln Thr Lys Leu Val Pro Arg Gln Glu
        915                 920                 925             
Phe Leu Asn Met Val Pro Asp Thr Glu Ala Glu Val Phe Ile Ser Val
    930                 935                 940                 
Gln Gly Asp Ile Leu Gly Glu Thr Ile Val Gly Ser Leu Thr Pro Ser
945                 950                 955                 960 
Glu Ile Gln Gln Leu Leu Arg Val Pro Thr Gly Cys Pro Glu Gln Thr
                965                 970                 975     
Leu Ser Ser Leu Thr Pro Val Ile Ile Leu Ser Arg Tyr Leu Asp Thr
            980                 985                 990         
Thr Gly Gln Trp Gly Lys Val Gly Val Glu His Arg Asp Gln Val Met
        995                 1000                1005            
Lys Asn Ile Val Ser Gly Tyr Thr Gln Met Leu Thr His Arg Ser Ser
    1010                1015                1020                
Asp Gly Thr Tyr His Thr Ser Lys Gly Asn Pro Gly Ser Thr Trp Leu
1025                1030                1035                1040
Thr Ser Tyr Val Phe Arg Val Phe Ala Leu Ala Tyr Ser Met Met Thr
                1045                1050                1055    
Thr Gln Val Leu Ser Leu Ser Ser Leu Cys Asp Met Ala Asn Trp Ile
            1060                1065                1070        
Ile Ile Asp Arg Gln Ala Glu Asp Gly His Phe Leu Glu Lys Gly Pro
        1075                1080                1085            
Val Val Met Thr Ser Met Gln Asp Gly Tyr Gln Gly Ser Glu Glu Asp
    1090                1095                1100                
Val Ser Leu Thr Ala Leu Val Leu Ile Ala Leu Asn Glu Gly Lys Glu
1105                1110                1115                1120
Leu Cys Arg Gln Lys Val Gly Pro Gln Arg Gly Gly Gln Asp Leu Ile
                1125                1130                1135    
Glu Arg Ala Arg Gly Phe Leu Glu Arg Lys Leu Pro Asp Ile Gln Thr
            1140                1145                1150        
Thr Phe Ala Val Ala Ile Ala Ser Tyr Ala Leu Ala Leu Ala Asn Ser
        1155                1160                1165            
Ser Gln Ala Asn Asp Cys Leu Asp Ser Phe Ala Ser Pro Asn Lys Thr
    1170                1175                1180                
His Trp Pro Val Asp Glu Gln Asn Leu Gly Ser Leu Tyr Thr Ile Glu
1185                1190                1195                1200
Ala Thr Ala Tyr Gly Leu Met Gln Lys Leu Glu Leu Gly Arg Tyr Asn
                1205                1210                1215    
Glu Thr His Ala Ile Ala Lys Trp Leu Leu Glu Lys Gln Glu Leu Gly
            1220                1225                1230        
Gly Gly Phe Arg Ser Thr Gln Thr Thr Val Val Ala Leu Glu Ala Leu
        1235                1240                1245            
Thr Arg Phe Arg Glu Ala Val Pro Phe Lys Gly Ile Gln Asp Leu His
    1250                1255                1260                
Val Gln Ile Arg Ala Pro Lys Thr Ala Leu Asn Val Asn Trp Tyr Ile
1265                1270                1275                1280
Asp His Ser Asn Ala Tyr Gln Gln Arg Ser Ala Lys Phe Leu Ala Gln
                1285                1290                1295    
Asp Asp Leu Glu Ile Lys Ala Ser Gly Asn Gly Arg Gly Thr Ile Ser
            1300                1305                1310        
Val Ala Leu Cys Cys Glu Trp Gln Arg Gly His Gly Glu Thr Trp Lys
        1315                1320                1325            
Glu Ala Thr Ala Leu Val Gln Ala Arg Asp Asn Ser Ser Gly Glu His
    1330                1335                1340                
Gly Glu Arg Gly Gly Arg Ile Val Gly Lys Asp Trp Gly Cys Glu Leu
1345                1350                1355                1360
Pro Gly Ser Arg Thr Ile Ala Thr Met Thr Ile Met Glu Val Ser Leu
                1365                1370                1375    
Leu Thr Gly Phe Tyr Pro Asn Gln Asp Asp Leu Lys Gln Leu Thr Ser
            1380                1385                1390        
Asp Val Glu Arg Tyr Ala Phe Gln Tyr Lys Thr Lys Thr Ser Thr Ser
        1395                1400                1405            
Asp Ser Thr Val Val Leu Tyr Leu Glu Lys Leu Ser His Glu Lys Asn
    1410                1415                1420                
Thr Val Leu Gly Phe Arg Val His Arg Met Leu Gln Ala Glu Phe Leu
1425                1430                1435                1440
Gln Ala Ala Leu Val Thr Ile Tyr Asp Tyr Tyr Glu Pro Ser Arg Arg
                1445                1450                1455    
Cys Ser Thr Phe Tyr Asn Leu Pro Thr Glu Gln Ser Ser Leu Arg Lys
            1460                1465                1470        
Ile Cys His Lys Asp Ile Cys Arg Cys Ala Glu Ala Lys Leu Glu Ser
        1475                1480                1485            
Val Glu Val Ser Ala Ser Asn Pro Tyr Val Tyr Tyr Asn Thr Gln Leu
    1490                1495                1500                
Glu Asp Ile Ile Lys Ser Gly Met Ser Gln Val Thr Lys Lys Glu Ser
1505                1510                1515                1520
Gln Cys Gly Val Thr Leu Gly Ala His Pro Gly Gly Pro Ile Val Trp
                1525                1530                1535    
Glu Gly Gln Thr Cys Val Cys Ala His Thr Gly Phe Ser Pro Gly Thr
            1540                1545                1550        
Asp Pro Ala Thr Pro Leu Ala Met Lys Lys Phe Val Ser His Ala Thr
        1555                1560                1565            
Cys His Asp Ser Leu Gly Leu Gln Glu Gln Glu Ser Tyr Leu Ile Met
    1570                1575                1580                
Gly Gln Thr Ser Asp Leu Trp Arg Ile Lys Ser Asp Tyr Ser Tyr Val
1585                1590                1595                1600
Leu Gly Lys Glu Thr Phe Leu Ile Leu Trp Pro Ala Asp Gly Asp Ala
                1605                1610                1615    
Ser Lys Lys Glu Leu Arg Asp Gln Leu Glu Glu Phe Leu Glu Tyr
            1620                1625                1630    


<210> 7041
<211> 1250
<212> PRT
<213> Homo sapiens

<400> 7041
Tyr Ile Leu Val Thr Pro Arg Val Leu Arg Val Gly Ser Pro Glu Ser
 1               5                  10                  15      
Ile His Ile Gln Ala His Ser Asp Ser Arg Gln Pro Leu Thr Arg Thr
            20                  25                  30          
Leu Lys Val Asn Leu Thr Val Trp Asp Phe Pro Met Arg Lys Thr Val
        35                  40                  45              
Leu Ala Arg Ser Gln Leu Ile Leu Ser Pro Gly Asn Asn Phe Met Asp
    50                  55                  60                  
Gln Ala Pro Val Thr Val Pro Glu Ser Leu Met Tyr Leu Pro Lys Pro
65                  70                  75                  80  
Gly Gln Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly
                85                  90                  95      
Ser Ser Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr
            100                 105                 110         
Ile Phe Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val
        115                 120                 125             
His Tyr Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg
    130                 135                 140                 
Thr Phe Thr Leu Asp Ile Lys Asn Pro Lys Gly Ile Thr Val Ile Ser
145                 150                 155                 160 
Gln Ser Leu Met Ala Lys Asp Gly Phe Phe Phe Ser Ser Phe His Leu
                165                 170                 175     
Pro Glu Leu Val Ser Leu Gly Thr Trp Thr Ile Glu Ala Ser Tyr Gln
            180                 185                 190         
Ser Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp Val Lys Glu Tyr
        195                 200                 205             
Val Leu Pro Ser Phe Glu Val Gln Leu Val Pro Asn Lys Thr Phe Phe
    210                 215                 220                 
Tyr Leu Lys Asp Glu Ala Leu Gly Val Asp Ile Gln Ala Arg Gln Trp
225                 230                 235                 240 
Asn Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn Lys Pro Val Asp Gly
                245                 250                 255     
His Ala Leu Val Ile Phe Gly Val Lys Leu Asp Ser Cys Arg Ile Pro
            260                 265                 270         
Ile Gln Ser Ser Leu Gln Arg Val Glu Ile Ser Glu Gly Leu Gly His
        275                 280                 285             
Val Ser Leu Gln Lys Asp Thr Leu Met Ala Ala Phe Gln Gly Pro Gly
    290                 295                 300                 
Glu Asp Phe Ile Gly Gly Ser Ile Phe Val Asn Val Thr Met Phe Ser
305                 310                 315                 320 
Ser Gly Gly Glu Met Val Gln Ala Glu Thr Ser Gly Val Lys Ile Ile
                325                 330                 335     
Gln Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro Gln Tyr Phe Lys
            340                 345                 350         
Pro Gly Met Pro Phe His Phe Arg Val Phe Ile Ser Asn Pro Asp Gly
        355                 360                 365             
Ser Pro Ala Ser Arg Val Leu Val His Ser Gln Asp Gln Lys Val Tyr
    370                 375                 380                 
Thr Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn Thr Asp Ala Asn
385                 390                 395                 400 
Leu Asp Lys Leu Pro Ile Glu Val Lys Thr Glu Glu Ser Leu Gln Pro
                405                 410                 415     
Glu Glu Gln Ala Ser Ala Lys Met Thr Ala Trp Pro Tyr Leu Thr Gln
            420                 425                 430         
Asp Gly Ser Gly Asn Phe Leu His Ile Glu Val Lys Thr Leu Gly Thr
        435                 440                 445             
Glu Val Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr Arg His Gln Asp
    450                 455                 460                 
Pro Lys Thr Lys Asp Lys Ile Thr His Phe Thr Ile Leu Val Leu Ser
465                 470                 475                 480 
Lys Gly Gln Thr Val Ser Ala Lys His Gln Ser Lys Ser Gln Gly Ser
                485                 490                 495     
Val Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser Ala Met Leu Pro Ser
            500                 505                 510         
Phe Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly Ala Ser Gln Asp
        515                 520                 525             
Pro Glu Leu Val Ala Asp Ser Ile Trp Ile Asp Val Asn Asp Arg Cys
    530                 535                 540                 
Ile Gly Met Leu Lys Val Gly Leu Lys Asn Asp Arg Phe Phe Gln Ser
545                 550                 555                 560 
Leu Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly Asp Ala Glu
                565                 570                 575     
Ala Thr Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr Val Leu Asn
            580                 585                 590         
Ser Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn Val Val Glu Glu
        595                 600                 605             
His Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg Phe Ala Val
    610                 615                 620                 
Phe Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly Met Asp Ser
625                 630                 635                 640 
Leu Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly Lys Arg Arg Ala
                645                 650                 655     
Glu Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln Lys Cys Cys Glu
            660                 665                 670         
Ala Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys Glu Glu Arg Thr
        675                 680                 685             
Trp His Val Arg His Gly Pro Ala Cys Val Ala Ala Phe Leu Asp Cys
    690                 695                 700                 
Cys His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg Glu Asp Gln Leu
705                 710                 715                 720 
His Leu Trp Thr Lys Asp Phe Asp Asp Leu Phe Leu Asp Asp Met Pro
                725                 730                 735     
Val Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp Arg Lys Phe Thr Leu
            740                 745                 750         
Pro Lys Ser Lys Ser Gly Ile Ser His Tyr Pro Ile Ser Val Lys Val
        755                 760                 765             
Pro Asp Ser Ile Thr Thr Trp Gln Phe Val Val Val Ser Leu Lys Ala
    770                 775                 780                 
Gly Gln Gly Leu Cys Val Ser Asp Pro Phe Glu Leu Thr Val Met Lys
785                 790                 795                 800 
Ser Phe Phe Val Asp Leu Lys Leu Pro Ser Ser Val Ile Arg Asn Glu
                805                 810                 815     
Gln Val Gln Ile Gln Ala Met Leu Tyr Asn Phe Arg Asp Arg Gln Ala
            820                 825                 830         
Lys Val Arg Val Glu Phe Pro His Lys Glu Thr Leu Cys Ser Ala Ser
        835                 840                 845             
Lys Pro Gly Ala Pro Ser His Gln Val Val Val Val Pro Pro Thr Ser
    850                 855                 860                 
Ser Lys Ile Val His Phe Val Leu Leu Pro Leu Glu Thr Gly Lys Val
865                 870                 875                 880 
Asp Val Glu Val Lys Ala Val Gly Tyr Gly Val Gln Asp His Val Lys
                885                 890                 895     
Lys Thr Leu Leu Val Arg Val Met Gly Thr Pro Asn Ser Leu Ala Leu
            900                 905                 910         
Val Gln Thr Ala Gly Leu Pro Pro Gly Pro Gly Trp Ala Gly Gln Thr
        915                 920                 925             
Gln Thr Lys Leu Val Pro Arg Gln Glu Phe Leu Asn Met Val Pro Asp
    930                 935                 940                 
Thr Glu Ala Glu Val Phe Ile Ser Val Gln Gly Asp Ile Leu Gly Glu
945                 950                 955                 960 
Thr Ile Val Gly Ser Leu Thr Pro Ser Glu Ile Gln Gln Leu Leu Arg
                965                 970                 975     
Val Pro Thr Gly Cys Pro Glu Gln Thr Leu Ser Ser Leu Thr Pro Val
            980                 985                 990         
Ile Ile Leu Ser Arg Tyr Leu Asp Thr Thr Gly Gln Trp Gly Lys Val
        995                 1000                1005            
Gly Val Glu His Arg Asp Gln Val Met Lys Asn Ile Val Ser Gly Tyr
    1010                1015                1020                
Thr Gln Met Leu Thr His Arg Ser Ser Asp Gly Thr Tyr His Thr Ser
1025                1030                1035                1040
Lys Gly Asn Pro Gly Ser Thr Trp Leu Thr Ser Tyr Val Phe Arg Val
                1045                1050                1055    
Phe Ala Leu Ala Tyr Ser Met Met Thr Thr Gln Val Leu Ser Leu Ser
            1060                1065                1070        
Ser Leu Cys Asp Met Ala Asn Trp Ile Ile Ile Asp Arg Gln Ala Glu
        1075                1080                1085            
Asp Gly His Phe Leu Glu Lys Gly Pro Val Val Met Thr Ser Met Gln
    1090                1095                1100                
Asp Gly Tyr Gln Gly Ser Glu Glu Asp Val Ser Leu Thr Ala Leu Val
1105                1110                1115                1120
Leu Ile Ala Leu Asn Glu Gly Lys Glu Leu Cys Arg Gln Lys Val Gly
                1125                1130                1135    
Pro Gln Arg Gly Gly Gln Asp Leu Ile Glu Arg Ala Arg Gly Phe Leu
            1140                1145                1150        
Glu Arg Lys Leu Pro Asp Ile Gln Thr Thr Phe Ala Val Ala Ile Ala
        1155                1160                1165            
Ser Tyr Ala Leu Ala Leu Ala Asn Ser Ser Gln Ala Asn Asp Cys Leu
    1170                1175                1180                
Asp Ser Phe Ala Ser Pro Ser Gly Tyr Lys Thr His Trp Pro Val Asp
1185                1190                1195                1200
Glu Gln Asn Leu Gly Ser Leu Tyr Thr Ile Glu Ala Thr Ala Tyr Gly
                1205                1210                1215    
Leu Met Gln Lys Leu Glu Leu Gly Arg Tyr Asn Glu Thr His Ala Ile
            1220                1225                1230        
Ala Lys Trp Leu Leu Glu Lys Gln Glu Leu Gly Gly Gly Phe Arg Ser
        1235                1240                1245            
Thr Gln
    1250


<210> 7042
<211> 1629
<212> PRT
<213> Homo sapiens

<400> 7042
Ile Leu Leu Leu Leu Gly Ser Pro Leu Ile His Ala Glu Pro Leu Tyr
 1               5                  10                  15      
Ile Leu Val Thr Pro Arg Val Leu Arg Val Gly Ser Pro Glu Ser Ile
            20                  25                  30          
His Ile Gln Ala His Ser Asp Ser Arg Gln Pro Leu Thr Arg Thr Leu
        35                  40                  45              
Lys Val Asn Leu Thr Val Trp Asp Phe Pro Met Arg Lys Thr Val Leu
    50                  55                  60                  
Ala Arg Ser Gln Leu Ile Leu Ser Pro Gly Asn Asn Phe Met Asp Gln
65                  70                  75                  80  
Ala Pro Val Thr Val Pro Glu Ser Leu Met Tyr Leu Pro Lys Pro Gly
                85                  90                  95      
Gln Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser
            100                 105                 110         
Ser Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile
        115                 120                 125             
Phe Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His
    130                 135                 140                 
Tyr Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr
145                 150                 155                 160 
Phe Thr Leu Asp Ile Lys Asn Pro Lys Gly Ile Thr Val Ile Ser Gln
                165                 170                 175     
Ser Leu Met Ala Lys Asp Gly Phe Phe Phe Ser Ser Phe His Leu Pro
            180                 185                 190         
Glu Leu Val Ser Leu Gly Thr Trp Thr Ile Glu Ala Ser Tyr Gln Ser
        195                 200                 205             
Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp Val Lys Glu Tyr Val
    210                 215                 220                 
Leu Pro Ser Phe Glu Val Gln Leu Val Pro Asn Lys Thr Phe Phe Tyr
225                 230                 235                 240 
Leu Lys Asp Glu Ala Leu Gly Val Asp Ile Gln Ala Arg Gln Trp Asn
                245                 250                 255     
Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn Lys Pro Val Asp Gly His
            260                 265                 270         
Ala Leu Val Ile Phe Gly Val Lys Leu Asp Ser Cys Arg Ile Pro Ile
        275                 280                 285             
Gln Ser Ser Leu Gln Arg Val Glu Ile Ser Glu Gly Leu Gly His Val
    290                 295                 300                 
Ser Leu Gln Lys Asp Thr Leu Met Ala Ala Phe Gln Gly Pro Gly Glu
305                 310                 315                 320 
Asp Phe Ile Gly Gly Ser Ile Phe Val Asn Val Thr Met Phe Ser Ser
                325                 330                 335     
Gly Gly Glu Met Val Gln Ala Glu Thr Ser Gly Val Lys Ile Ile Gln
            340                 345                 350         
Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro Gln Tyr Phe Lys Pro
        355                 360                 365             
Gly Met Pro Phe His Phe Arg Val Phe Ile Ser Asn Pro Asp Gly Ser
    370                 375                 380                 
Pro Ala Ser Arg Val Leu Val His Ser Gln Asp Gln Lys Val Tyr Thr
385                 390                 395                 400 
Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn Thr Asp Ala Asn Leu
                405                 410                 415     
Asp Lys Leu Pro Ile Glu Val Lys Thr Glu Glu Ser Leu Gln Pro Glu
            420                 425                 430         
Glu Gln Ala Ser Ala Lys Met Thr Ala Trp Pro Tyr Leu Thr Gln Asp
        435                 440                 445             
Gly Ser Gly Asn Phe Leu His Ile Glu Val Lys Thr Leu Gly Thr Glu
    450                 455                 460                 
Val Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr Arg His Gln Asp Pro
465                 470                 475                 480 
Lys Thr Lys Asp Lys Ile Thr His Phe Thr Ile Leu Val Leu Ser Lys
                485                 490                 495     
Gly Gln Thr Val Ser Ala Lys His Gln Ser Lys Ser Gln Gly Ser Val
            500                 505                 510         
Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser Ala Met Leu Pro Ser Phe
        515                 520                 525             
Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly Ala Ser Gln Asp Pro
    530                 535                 540                 
Glu Leu Val Ala Asp Ser Ile Trp Ile Asp Val Asn Asp Arg Cys Ile
545                 550                 555                 560 
Gly Met Leu Lys Val Gly Leu Lys Asn Asp Arg Phe Phe Gln Ser Leu
                565                 570                 575     
Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly Asp Ala Glu Ala
            580                 585                 590         
Thr Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr Val Leu Asn Ser
        595                 600                 605             
Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn Val Val Glu Glu His
    610                 615                 620                 
Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg Phe Ala Val Phe
625                 630                 635                 640 
Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly Met Asp Ser Leu
                645                 650                 655     
Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly Lys Arg Arg Ala Glu
            660                 665                 670         
Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln Lys Cys Cys Glu Ala
        675                 680                 685             
Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys Glu Glu Arg Thr Trp
    690                 695                 700                 
His Val Arg His Gly Pro Ala Cys Val Ala Ala Phe Leu Asp Cys Cys
705                 710                 715                 720 
His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg Glu Asp Gln Leu His
                725                 730                 735     
Leu Trp Thr Lys Glu Asp Phe Asp Asp Leu Phe Leu Asp Asp Met Pro
            740                 745                 750         
Val Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp Arg Lys Phe Thr Leu
        755                 760                 765             
Pro Lys Ser Lys Ser Gly Ile Ser His Tyr Pro Ile Ser Val Lys Val
    770                 775                 780                 
Pro Asp Ser Ile Thr Thr Trp Gln Phe Val Val Val Ser Leu Lys Ala
785                 790                 795                 800 
Gly Gln Gly Leu Cys Val Ser Asp Pro Phe Glu Leu Thr Val Met Lys
                805                 810                 815     
Ser Phe Phe Val Asp Leu Lys Leu Pro Ser Ser Val Ile Arg Asn Glu
            820                 825                 830         
Gln Val Gln Ile Gln Ala Met Leu Tyr Asn Phe Arg Asp Arg Gln Ala
        835                 840                 845             
Lys Val Arg Val Glu Phe Pro His Lys Glu Thr Leu Cys Ser Ala Ser
    850                 855                 860                 
Lys Pro Gly Ala Pro Ser His Gln Val Val Val Val Pro Pro Thr Ser
865                 870                 875                 880 
Ser Lys Ile Val His Phe Val Leu Leu Pro Leu Glu Thr Gly Lys Val
                885                 890                 895     
Asp Val Glu Val Lys Ala Val Gly Tyr Gly Val Gln Asp His Val Lys
            900                 905                 910         
Lys Thr Leu Leu Val Arg Val Met Gly Thr Pro Asn Ser Leu Ala Ala
        915                 920                 925             
Gly Ala Asp Ser Gly Ala Ser Thr Arg Ser Arg Leu Gly Arg Gln Glu
    930                 935                 940                 
Phe Leu Asn Met Val Pro Asp Thr Glu Ala Glu Val Phe Ile Ser Val
945                 950                 955                 960 
Gln Gly Asp Ile Leu Gly Glu Thr Ile Val Gly Ser Leu Thr Pro Ser
                965                 970                 975     
Glu Ile Gln Gln Leu Leu Arg Val Pro Thr Gly Cys Pro Glu Gln Thr
            980                 985                 990         
Leu Ser Ser Leu Thr Pro Val Ile Ile Leu Ser Arg Tyr Leu Asp Thr
        995                 1000                1005            
Thr Gly Gln Trp Gly Lys Val Gly Val Glu His Arg Asp Gln Val Met
    1010                1015                1020                
Lys Asn Ile Val Ser Gly Tyr Thr Gln Met Leu Thr His Arg Ser Ser
1025                1030                1035                1040
Asp Gly Thr Tyr His Thr Ser Lys Gly Asn Pro Gly Ser Thr Trp Leu
                1045                1050                1055    
Thr Ser Tyr Val Phe Arg Val Phe Ala Leu Ala Tyr Ser Met Met Thr
            1060                1065                1070        
Thr Gln Val Leu Ser Leu Ser Ser Leu Cys Asp Met Ala Asn Trp Ile
        1075                1080                1085            
Ile Ile Asp Arg Gln Ala Glu Asp Gly His Phe Leu Glu Lys Gly Pro
    1090                1095                1100                
Val Val Met Thr Ser Met Gln Asp Gly Tyr Gln Gly Ser Glu Glu Asp
1105                1110                1115                1120
Val Ser Leu Thr Ala Leu Val Leu Ile Ala Leu Asn Glu Gly Lys Glu
                1125                1130                1135    
Leu Cys Arg Gln Lys Val Gly Pro Gln Arg Gly Gly Gln Asp Leu Ile
            1140                1145                1150        
Glu Arg Ala Arg Gly Phe Leu Glu Arg Lys Leu Pro Asp Ile Gln Thr
        1155                1160                1165            
Thr Phe Ala Val Ala Ile Ala Ser Tyr Ala Leu Ala Leu Ala Asn Ser
    1170                1175                1180                
Ser Gln Ala Asn Asp Cys Leu Asp Ser Phe Ala Ser Pro Met Asp Glu
1185                1190                1195                1200
Gln Asn Leu Gly Ser Leu Tyr Thr Ile Glu Ala Thr Ala Tyr Gly Leu
                1205                1210                1215    
Met Gln Lys Leu Glu Leu Gly Arg Tyr Asn Glu Thr His Ala Ile Ala
            1220                1225                1230        
Lys Trp Leu Leu Glu Lys Gln Glu Leu Gly Gly Gly Phe Arg Ser Thr
        1235                1240                1245            
Gln Thr Thr Val Val Ala Leu Glu Ala Leu Thr Arg Phe Arg Glu Ala
    1250                1255                1260                
Val Pro Phe Lys Gly Ile Gln Asp Leu His Val Gln Ile Arg Ala Pro
1265                1270                1275                1280
Lys Thr Ala Leu Asn Val Asn Trp Tyr Ile Asp His Ser Asn Ala Tyr
                1285                1290                1295    
Gln Gln Arg Glu Met Glu Asn Glu Ser Pro Gly Pro Arg Leu Gly Lys
            1300                1305                1310        
Thr Glu Ala Leu Val Ser Val Gln Ala Pro His Pro Pro Thr Leu Asp
        1315                1320                1325            
Pro His Phe Ala Ala Ser Ser Thr Leu Lys Ser Ser Ser Leu Phe Ser
    1330                1335                1340                
Ser Val Pro Cys Pro Gly Arg Pro Arg Asp Gln Ser Gln Trp Gln Arg
1345                1350                1355                1360
Glu Arg His His Leu Glu Ala Thr Met Thr Ile Met Glu Val Ser Leu
                1365                1370                1375    
Leu Thr Gly Phe Tyr Pro Asn Gln Asp Asp Leu Lys Gln Leu Thr Ser
            1380                1385                1390        
Asp Val Glu Arg Tyr Ala Phe Gln Tyr Lys Thr Lys Thr Ser Thr Ser
        1395                1400                1405            
Asp Ser Thr Val Val Leu Tyr Leu Glu Lys Leu Ser His Glu Lys Asn
    1410                1415                1420                
Thr Val Leu Gly Phe Arg Val His Arg Met Leu Gln Ala Glu Phe Leu
1425                1430                1435                1440
Gln Ala Ala Leu Val Thr Ile Tyr Asp Tyr Tyr Glu Pro Ser Arg Arg
                1445                1450                1455    
Cys Ser Thr Phe Tyr Asn Leu Pro Thr Glu Gln Ser Ser Leu Arg Lys
            1460                1465                1470        
Ile Cys His Lys Asp Ile Cys Arg Cys Ala Glu Gly Gln Cys Pro Ser
        1475                1480                1485            
Leu Gln Lys Pro Ser Gly Gln Leu Arg Gln Glu Glu Leu Gln Thr Thr
    1490                1495                1500                
Ala Cys Glu Ala Gly Val Asp Phe Val Tyr Lys Thr Lys Leu Glu Ser
1505                1510                1515                1520
Val Glu Val Ser Ala Ser Asn Pro Tyr Val Tyr Tyr Asn Thr Gln Leu
                1525                1530                1535    
Glu Asp Ile Ile Lys Ser Gly Thr Asp Pro Ala Thr Pro Leu Ala Met
            1540                1545                1550        
Lys Lys Phe Val Ser His Ala Thr Cys His Asp Ser Leu Gly Leu Gln
        1555                1560                1565            
Glu Gln Glu Ser Tyr Leu Ile Met Gly Gln Thr Ser Asp Leu Trp Arg
    1570                1575                1580                
Ile Lys Ser Asp Tyr Ser Tyr Val Leu Gly Lys Glu Thr Phe Leu Ile
1585                1590                1595                1600
Leu Trp Pro Ala Asp Gly Asp Ala Ser Lys Lys Glu Leu Arg Asp Gln
                1605                1610                1615    
Leu Glu Glu Phe Leu Glu Tyr Met Arg Thr His Gly Cys
            1620                1625                


<210> 7043
<211> 1510
<212> PRT
<213> Homo sapiens

<400> 7043
Gln Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser
 1               5                  10                  15      
Ser Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile
            20                  25                  30          
Phe Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Glu Gly
        35                  40                  45              
Ser His Gln Pro His Pro Leu Ser Pro Gln Asn Pro Lys Gly Ile Thr
    50                  55                  60                  
Val Ile Ser Gln Ser Leu Met Ala Lys Asp Gly Phe Phe Phe Ser Ser
65                  70                  75                  80  
Phe His Leu Pro Glu Leu Val Ser Leu Gly Thr Trp Thr Ile Glu Ala
                85                  90                  95      
Ser Tyr Gln Ser Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp Val
            100                 105                 110         
Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Gln Leu Val Pro Asn Lys
        115                 120                 125             
Thr Phe Phe Tyr Leu Lys Asp Glu Ala Leu Gly Val Asp Ile Gln Ala
    130                 135                 140                 
Arg Gln Trp Asn Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn Lys Pro
145                 150                 155                 160 
Val Asp Gly His Ala Leu Val Ile Phe Gly Val Lys Leu Asp Ser Cys
                165                 170                 175     
Arg Ile Pro Ile Gln Ser Ser Leu Gln Arg Val Glu Ile Ser Glu Gly
            180                 185                 190         
Leu Gly His Val Ser Leu Gln Lys Asp Thr Leu Met Ala Ala Phe Gln
        195                 200                 205             
Gly Pro Gly Glu Asp Phe Ile Gly Gly Ser Ile Phe Val Asn Val Thr
    210                 215                 220                 
Met Phe Ser Ser Gly Gly Glu Met Val Gln Ala Glu Thr Ser Gly Val
225                 230                 235                 240 
Lys Ile Ile Gln Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro Gln
                245                 250                 255     
Tyr Phe Lys Pro Gly Met Pro Phe His Phe Arg Val Phe Ile Ser Asn
            260                 265                 270         
Pro Asp Gly Ser Pro Ala Ser Arg Val Leu Val His Ser Gln Asp Gln
        275                 280                 285             
Lys Val Tyr Thr Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn Thr
    290                 295                 300                 
Asp Ala Asn Leu Asp Lys Leu Pro Ile Glu Val Lys Thr Glu Glu Ser
305                 310                 315                 320 
Leu Gln Pro Glu Glu Gln Ala Ser Ala Lys Met Thr Ala Trp Pro Tyr
                325                 330                 335     
Leu Thr Gln Asp Gly Ser Gly Asn Phe Leu His Ile Glu Val Lys Thr
            340                 345                 350         
Leu Gly Thr Glu Val Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr Arg
        355                 360                 365             
His Gln Asp Pro Lys Thr Lys Asp Lys Ile Thr His Phe Thr Ile Leu
    370                 375                 380                 
Val Leu Ser Lys Gly Gln Thr Val Ser Ala Lys His Gln Ser Lys Ser
385                 390                 395                 400 
Gln Gly Ser Val Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser Ala Met
                405                 410                 415     
Leu Pro Ser Phe Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly Ala
            420                 425                 430         
Ser Gln Asp Pro Glu Leu Val Ala Asp Ser Ile Trp Ile Asp Val Asn
        435                 440                 445             
Asp Arg Cys Ile Gly Met Leu Lys Val Gly Leu Lys Asn Asp Arg Phe
    450                 455                 460                 
Phe Gln Ser Leu Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly
465                 470                 475                 480 
Asp Ala Glu Ala Thr Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr
                485                 490                 495     
Val Leu Asn Ser Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn Val
            500                 505                 510         
Val Glu Glu His Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg
        515                 520                 525             
Phe Ala Val Phe Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly
    530                 535                 540                 
Met Asp Ser Leu Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly Lys
545                 550                 555                 560 
Arg Arg Ala Glu Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln Lys
                565                 570                 575     
Cys Cys Glu Ala Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys Glu
            580                 585                 590         
Glu Arg Thr Trp His Val Arg His Gly Pro Ala Cys Val Ala Ala Phe
        595                 600                 605             
Leu Asp Cys Cys His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg Glu
    610                 615                 620                 
Asp Gln Leu His Leu Trp Thr Thr Asp Glu Glu Glu Asp Phe Asp Asp
625                 630                 635                 640 
Leu Phe Leu Asp Asp Met Pro Val Arg Thr Leu Phe Pro Glu Ser Trp
                645                 650                 655     
Leu Trp Arg Lys Phe Thr Leu Pro Lys Ser Lys Ser Gly Ile Ser His
            660                 665                 670         
Tyr Pro Ile Ser Val Lys Val Pro Asp Ser Ile Thr Thr Trp Gln Phe
        675                 680                 685             
Val Val Val Ser Leu Lys Ala Gly Gln Gly Leu Cys Val Ser Asp Pro
    690                 695                 700                 
Phe Glu Leu Thr Val Met Lys Ser Phe Phe Val Asp Leu Lys Leu Pro
705                 710                 715                 720 
Ser Ser Val Ile Arg Asn Glu Gln Val Gln Ile Gln Ala Met Leu Tyr
                725                 730                 735     
Asn Phe Arg Asp Arg Gln Ala Lys Val Arg Val Glu Phe Pro His Lys
            740                 745                 750         
Glu Thr Leu Cys Ser Ala Ser Lys Pro Gly Ala Pro Ser His Gln Val
        755                 760                 765             
Val Val Val Pro Pro Thr Ser Ser Lys Ile Val His Phe Val Leu Leu
    770                 775                 780                 
Pro Leu Glu Thr Gly Lys Val Asp Val Glu Val Lys Ala Val Gly Tyr
785                 790                 795                 800 
Gly Val Gln Asp His Val Lys Lys Thr Leu Leu Val Arg Val Met Gly
                805                 810                 815     
Thr Pro Asn Ser Leu Ala Ala Gly Ala Asp Ser Gly Ala Ser Thr Arg
            820                 825                 830         
Ser Arg Leu Gly Arg Gln Glu Phe Leu Asn Met Val Pro Asp Thr Glu
        835                 840                 845             
Ala Glu Val Phe Ile Ser Val Gln Gly Asp Ile Leu Gly Glu Thr Ile
    850                 855                 860                 
Val Gly Ser Leu Thr Pro Ser Glu Ile Gln Gln Leu Leu Arg Val Pro
865                 870                 875                 880 
Thr Gly Cys Pro Glu Gln Thr Leu Ser Ser Leu Thr Pro Val Ile Ile
                885                 890                 895     
Leu Ser Arg Tyr Leu Asp Thr Thr Gly Gln Trp Gly Lys Val Gly Val
            900                 905                 910         
Glu His Arg Asp Gln Val Met Lys Asn Ile Val Ser Gly Tyr Thr Gln
        915                 920                 925             
Met Leu Thr His Arg Ser Ser Asp Gly Thr Tyr His Thr Ser Lys Gly
    930                 935                 940                 
Asn Pro Gly Ser Thr Trp Leu Thr Ser Tyr Val Phe Arg Val Phe Ala
945                 950                 955                 960 
Leu Ala Tyr Ser Met Met Thr Thr Gln Val Leu Ser Leu Ser Ser Leu
                965                 970                 975     
Cys Asp Met Ala Asn Trp Ile Ile Ile Asp Arg Gln Ala Glu Asp Gly
            980                 985                 990         
His Phe Leu Glu Lys Gly Pro Val Val Met Thr Ser Met Gln Asp Gly
        995                 1000                1005            
Tyr Gln Gly Ser Glu Glu Asp Val Ser Leu Thr Ala Leu Val Leu Ile
    1010                1015                1020                
Ala Leu Asn Glu Gly Lys Glu Leu Cys Arg Gln Lys Asn Leu Met Ala
1025                1030                1035                1040
Ser Ile Glu Arg Ala Arg Gly Phe Leu Glu Arg Lys Leu Pro Asp Ile
                1045                1050                1055    
Gln Thr Thr Phe Ala Val Ala Ile Ala Ser Tyr Ala Leu Ala Leu Ala
            1060                1065                1070        
Asn Ser Ser Gln Ala Asn Asp Cys Leu Asp Ser Phe Ala Ser Pro Ser
        1075                1080                1085            
Gly Tyr Lys Thr His Trp Pro Val Asp Glu Gln Asn Leu Gly Ser Leu
    1090                1095                1100                
Tyr Thr Ile Glu Ala Thr Ala Tyr Gly Leu Met Gln Lys Leu Glu Leu
1105                1110                1115                1120
Gly Arg Tyr Asn Glu Thr His Ala Ile Ala Lys Trp Leu Leu Glu Lys
                1125                1130                1135    
Gln Glu Leu Gly Gly Gly Phe Arg Ser Thr Gln Val Met Gly Thr Pro
            1140                1145                1150        
Gly Arg Leu Gln Thr Leu Leu Trp Pro Leu His Leu Gly Ile Asp Gly
        1155                1160                1165            
Val Gly Gly Gly Asn Leu Ala Val Asn Ser Pro His Gly Gln Arg Pro
    1170                1175                1180                
Gly Lys Ser Arg Ile Gly Val Gln Arg Lys Gly Ser Gly Trp Gly Arg
1185                1190                1195                1200
Ala Leu Thr Ala Pro Leu Ala Arg Gln Ile Leu Thr Met Tyr His Lys
                1205                1210                1215    
Ser Pro Glu Ser Arg Glu Asp Asn Cys Asn Leu Phe Leu Leu Ala Lys
            1220                1225                1230        
Ala Leu Cys Cys Glu Trp Gln Arg Gly His Gly Glu Thr Trp Lys Glu
        1235                1240                1245            
Ala Thr Ala Leu Val Gln Ala Arg Asp Asn Ser Lys Ala Thr Met Thr
    1250                1255                1260                
Ile Met Glu Val Ser Leu Leu Thr Gly Phe Tyr Pro Asn Gln Asp Asp
1265                1270                1275                1280
Leu Lys Gln Leu Thr Ser Asp Val Glu Arg Tyr Ala Phe Gln Tyr Lys
                1285                1290                1295    
Thr Lys Thr Ser Thr Ser Asp Ser Thr Val Val Leu Tyr Leu Glu Lys
            1300                1305                1310        
Leu Ser His Glu Lys Asn Thr Val Leu Gly Phe Arg Val His Arg Met
        1315                1320                1325            
Leu Gln Ala Glu Phe Leu Gln Ala Ala Leu Val Thr Ile Tyr Asp Tyr
    1330                1335                1340                
Tyr Glu Pro Ser Arg Arg Cys Ser Thr Phe Tyr Asn Leu Pro Thr Glu
1345                1350                1355                1360
Gln Ser Ser Leu Arg Lys Ile Cys His Lys Asp Ile Cys Arg Cys Ala
                1365                1370                1375    
Glu Gly Gln Cys Pro Ser Leu Gln Lys Pro Ser Gly Gln Leu Arg Gln
            1380                1385                1390        
Glu Glu Leu Gln Thr Thr Ala Cys Glu Ala Gly Val Asp Phe Val Tyr
        1395                1400                1405            
Lys Thr Lys Leu Glu Ser Val Glu Val Ser Ala Ser Asn Pro Tyr Val
    1410                1415                1420                
Tyr Tyr Asn Thr Gln Leu Glu Asp Ile Ile Lys Ser Gly Thr Asp Pro
1425                1430                1435                1440
Ala Thr Pro Leu Ala Met Lys Lys Phe Val Ser His Ala Thr Cys His
                1445                1450                1455    
Asp Ser Leu Gly Leu Gln Glu Gln Glu Ser Tyr Leu Ile Met Gly Gln
            1460                1465                1470        
Thr Ser Asp Leu Trp Arg Ile Lys Ser Asp Tyr Ser Tyr Val Leu Gly
        1475                1480                1485            
Lys Glu Thr Phe Leu Ile Leu Trp Pro Ala Asp Gly Asp Ala Ser Lys
    1490                1495                1500                
Lys Glu Leu Arg Asp Gln
1505                1510


<210> 7044
<211> 1644
<212> PRT
<213> Homo sapiens

<400> 7044
Ile Leu Leu Leu Leu Gly Ser Pro Leu Ile His Ala Glu Pro Leu Tyr
 1               5                  10                  15      
Ile Leu Val Thr Pro Arg Val Leu Arg Val Gly Ser Pro Glu Ser Ile
            20                  25                  30          
His Ile Gln Ala His Ser Asp Ser Arg Gln Pro Leu Thr Arg Thr Leu
        35                  40                  45              
Lys Val Asn Leu Thr Val Trp Asp Phe Pro Met Arg Lys Thr Val Leu
    50                  55                  60                  
Ala Arg Ser Gln Leu Ile Leu Ser Pro Gly Asn Asn Phe Met Asp Gln
65                  70                  75                  80  
Ala Pro Val Thr Val Pro Glu Ser Leu Met Tyr Leu Pro Lys Pro Gly
                85                  90                  95      
Gln Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser
            100                 105                 110         
Ser Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile
        115                 120                 125             
Phe Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His
    130                 135                 140                 
Tyr Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr
145                 150                 155                 160 
Phe Thr Leu Asp Ile Lys Asn Pro Lys Gly Ile Thr Val Ile Ser Gln
                165                 170                 175     
Ser Leu Met Ala Lys Asp Gly Phe Phe Phe Ser Ser Phe His Leu Pro
            180                 185                 190         
Glu Leu Val Ser Leu Gly Thr Trp Thr Ile Glu Ala Ser Tyr Gln Ser
        195                 200                 205             
Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp Val Lys Glu Tyr Val
    210                 215                 220                 
Leu Pro Ser Phe Glu Val Gln Leu Val Pro Asn Lys Thr Phe Phe Tyr
225                 230                 235                 240 
Leu Lys Asp Glu Ala Leu Gly Val Asp Ile Gln Ala Arg Gln Trp Asn
                245                 250                 255     
Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn Lys Pro Val Asp Gly His
            260                 265                 270         
Ala Leu Val Ile Phe Gly Val Lys Leu Asp Ser Cys Arg Ile Pro Ile
        275                 280                 285             
Gln Ser Ser Leu Gln Arg Val Glu Ile Ser Glu Gly Leu Gly His Val
    290                 295                 300                 
Ser Leu Gln Lys Asp Thr Leu Met Ala Ala Phe Gln Gly Pro Gly Glu
305                 310                 315                 320 
Asp Phe Ile Gly Gly Ser Ile Phe Val Asn Val Thr Met Phe Ser Ser
                325                 330                 335     
Gly Gly Glu Met Val Gln Ala Glu Thr Ser Gly Val Lys Ile Ile Gln
            340                 345                 350         
Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro Gln Tyr Phe Lys Pro
        355                 360                 365             
Gly Met Pro Phe His Phe Arg Val Phe Ile Ser Asn Pro Asp Gly Ser
    370                 375                 380                 
Pro Ala Ser Arg Val Leu Val His Ser Gln Asp Gln Lys Val Tyr Thr
385                 390                 395                 400 
Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn Thr Asp Ala Asn Leu
                405                 410                 415     
Asp Lys Leu Pro Ile Glu Val Lys Thr Glu Glu Ser Leu Gln Pro Glu
            420                 425                 430         
Glu Gln Ala Ser Ala Lys Met Thr Ala Trp Pro Tyr Leu Thr Gln Asp
        435                 440                 445             
Gly Ser Gly Asn Phe Leu His Ile Glu Val Lys Thr Leu Gly Thr Glu
    450                 455                 460                 
Val Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr Arg His Gln Asp Pro
465                 470                 475                 480 
Lys Thr Lys Asp Lys Ile Thr His Phe Thr Ile Leu Val Leu Ser Lys
                485                 490                 495     
Gly Gln Thr Val Ser Ala Lys His Gln Ser Lys Ser Gln Gly Ser Val
            500                 505                 510         
Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser Ala Met Leu Pro Ser Phe
        515                 520                 525             
Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly Ala Ser Gln Asp Pro
    530                 535                 540                 
Glu Leu Val Ala Asp Ser Ile Trp Ile Asp Val Asn Asp Arg Cys Ile
545                 550                 555                 560 
Gly Met Leu Lys Val Gly Leu Lys Asn Asp Arg Phe Phe Gln Ser Leu
                565                 570                 575     
Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly Asp Ala Glu Ala
            580                 585                 590         
Thr Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr Val Leu Asn Ser
        595                 600                 605             
Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn Val Val Glu Glu His
    610                 615                 620                 
Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg Phe Ala Val Phe
625                 630                 635                 640 
Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly Met Asp Ser Leu
                645                 650                 655     
Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly Lys Arg Arg Ala Glu
            660                 665                 670         
Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln Lys Cys Cys Glu Ala
        675                 680                 685             
Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys Glu Glu Arg Thr Trp
    690                 695                 700                 
His Val Arg His Gly Pro Ala Cys Val Ala Ala Phe Leu Asp Cys Cys
705                 710                 715                 720 
His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg Glu Asp Gln Leu His
                725                 730                 735     
Leu Trp Thr Thr Asp Glu Glu Glu Asp Phe Asp Asp Leu Phe Leu Asp
            740                 745                 750         
Asp Met Pro Val Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp Arg Lys
        755                 760                 765             
Phe Thr Leu Pro Lys Ser Lys Ser Gly Ile Ser His Tyr Pro Ile Ser
    770                 775                 780                 
Val Lys Val Pro Asp Ser Ile Thr Thr Trp Gln Phe Val Val Val Ser
785                 790                 795                 800 
Leu Lys Ala Gly Gln Gly Leu Cys Val Ser Asp Pro Phe Glu Leu Thr
                805                 810                 815     
Val Met Lys Ser Phe Phe Val Asp Leu Lys Leu Pro Ser Ser Val Ile
            820                 825                 830         
Arg Asn Glu Gln Val Gln Ile Gln Ala Met Leu Tyr Asn Phe Arg Asp
        835                 840                 845             
Arg Gln Ala Lys Val Arg Val Glu Phe Pro His Lys Glu Thr Leu Cys
    850                 855                 860                 
Ser Ala Ser Lys Pro Gly Ala Pro Ser His Gln Val Val Val Val Pro
865                 870                 875                 880 
Pro Thr Ser Ser Lys Ile Val His Phe Val Leu Leu Pro Leu Glu Thr
                885                 890                 895     
Gly Lys Val Asp Val Glu Val Lys Ala Val Gly Tyr Gly Val Gln Asp
            900                 905                 910         
His Val Lys Lys Thr Leu Leu Val Arg Val Met Gly Thr Pro Asn Ser
        915                 920                 925             
Leu Ala Ala Gly Ala Asp Ser Gly Ala Ser Thr Ser Pro Leu Val Thr
    930                 935                 940                 
Glu Gly Cys Gly Tyr Ser Gly Gln Thr Gln Thr Lys Leu Val Pro Arg
945                 950                 955                 960 
Gln Glu Phe Leu Asn Met Val Pro Asp Thr Glu Ala Glu Val Phe Ile
                965                 970                 975     
Ser Val Gln Gly Asp Ile Leu Gly Glu Thr Ile Val Gly Ser Leu Thr
            980                 985                 990         
Pro Ser Glu Ile Gln Gln Leu Leu Arg Val Pro Thr Gly Cys Pro Glu
        995                 1000                1005            
Gln Thr Leu Ser Ser Leu Thr Pro Val Ile Ile Leu Ser Arg Tyr Leu
    1010                1015                1020                
Asp Thr Thr Gly Gln Trp Gly Lys Val Gly Val Glu His Arg Asp Gln
1025                1030                1035                1040
Val Met Lys Asn Ile Val Ser Gly Tyr Thr Gln Met Leu Thr His Arg
                1045                1050                1055    
Ser Ser Asp Gly Thr Tyr His Thr Ser Lys Gly Asn Pro Gly Ser Thr
            1060                1065                1070        
Trp Leu Thr Ser Tyr Val Phe Arg Val Phe Ala Leu Ala Tyr Ser Met
        1075                1080                1085            
Met Thr Thr Gln Val Leu Ser Leu Ser Ser Leu Cys Asp Met Ala Asn
    1090                1095                1100                
Trp Ile Ile Ile Asp Arg Gln Ala Glu Asp Gly His Phe Leu Glu Lys
1105                1110                1115                1120
Gly Pro Val Val Met Thr Ser Met Gln Asp Gly Tyr Gln Gly Ser Glu
                1125                1130                1135    
Glu Asp Val Ser Leu Thr Ala Leu Val Leu Ile Ala Leu Asn Glu Gly
            1140                1145                1150        
Lys Glu Leu Cys Arg Gln Lys Val Gly Pro Gln Arg Gly Gly Gln Asp
        1155                1160                1165            
Leu Ile Glu Arg Ala Arg Gly Phe Leu Glu Arg Lys Leu Pro Asp Ile
    1170                1175                1180                
Gln Thr Thr Phe Ala Val Ala Ile Ala Ser Tyr Ala Leu Ala Leu Ala
1185                1190                1195                1200
Asn Ser Ser Gln Ala Asn Asp Cys Leu Asp Ser Phe Ala Ser Pro Ser
                1205                1210                1215    
Gly Tyr Lys Thr His Trp Pro Val Asp Glu Gln Asn Leu Gly Ser Leu
            1220                1225                1230        
Tyr Thr Ile Glu Ala Thr Ala Tyr Gly Leu Met Gln Lys Leu Glu Leu
        1235                1240                1245            
Gly Arg Tyr Asn Glu Thr His Ala Ile Ala Lys Trp Leu Leu Glu Lys
    1250                1255                1260                
Gln Glu Leu Gly Gly Gly Phe Arg Ser Thr Gln Val Met Gly Thr Pro
1265                1270                1275                1280
Gly Arg Leu His Ile Pro Leu His Leu Thr Leu Thr Leu Leu Leu Pro
                1285                1290                1295    
Pro Pro Leu Asn Leu Pro Leu Cys Ser Leu Gln Phe Leu Ala Gln Asp
            1300                1305                1310        
Asp Leu Glu Ile Lys Ala Ser Gly Asn Gly Arg Gly Thr Ile Ser Val
        1315                1320                1325            
Ala Leu Cys Cys Glu Trp Gln Arg Gly His Gly Glu Thr Trp Lys Glu
    1330                1335                1340                
Ala Thr Ala Leu Val Gln Ala Arg Asp Asn Ser Ser Gly Glu His Gly
1345                1350                1355                1360
Glu Arg Gly Gly Arg Ile Val Gly Lys Asp Trp Gly Cys Glu Leu Pro
                1365                1370                1375    
Gly Ser Arg Thr Ile Ala Thr Met Thr Ile Met Glu Val Ser Leu Leu
            1380                1385                1390        
Thr Gly Phe Tyr Pro Asn Gln Asp Asp Leu Lys Gln Leu Thr Ser Asp
        1395                1400                1405            
Val Glu Arg Tyr Ala Phe Gln Tyr Lys Thr Lys Thr Ser Thr Ser Asp
    1410                1415                1420                
Ser Thr Val Val Leu Tyr Leu Glu Lys Leu Ser His Glu Lys Asn Thr
1425                1430                1435                1440
Val Leu Gly Phe Arg Val His Arg Met Leu Gln Ala Glu Phe Leu Gln
                1445                1450                1455    
Ala Ala Leu Val Thr Ile Tyr Asp Tyr Tyr Glu Pro Ser Arg Arg Cys
            1460                1465                1470        
Ser Thr Phe Tyr Asn Leu Pro Thr Glu Gln Ser Ser Leu Arg Lys Ile
        1475                1480                1485            
Cys His Lys Asp Ile Cys Arg Cys Ala Glu Gly Gln Cys Pro Ser Leu
    1490                1495                1500                
Gln Lys Pro Ser Gly Gln Leu Arg Gln Glu Glu Leu Gln Thr Thr Ala
1505                1510                1515                1520
Cys Glu Ala Gly Val Asp Phe Val Tyr Lys Thr Lys Leu Glu Ser Val
                1525                1530                1535    
Glu Val Ser Ala Ser Asn Pro Tyr Val Tyr Tyr Asn Thr Gln Leu Glu
            1540                1545                1550        
Asp Ile Ile Lys Ser Gly Thr Asp Pro Ala Thr Pro Leu Ala Met Lys
        1555                1560                1565            
Lys Phe Val Ser His Ala Thr Cys His Asp Ser Leu Gly Leu Gln Glu
    1570                1575                1580                
Gln Glu Ser Tyr Leu Ile Met Gly Gln Thr Ser Asp Leu Trp Arg Ile
1585                1590                1595                1600
Lys Ser Asp Tyr Ser Tyr Val Leu Gly Lys Glu Thr Phe Leu Ile Leu
                1605                1610                1615    
Trp Pro Ala Asp Gly Asp Ala Ser Lys Lys Glu Leu Arg Asp Gln Leu
            1620                1625                1630        
Glu Glu Phe Leu Glu Tyr Met Arg Thr His Gly Cys
        1635                1640                


<210> 7045
<211> 1252
<212> PRT
<213> Homo sapiens

<400> 7045
Ile Leu Val Thr Pro Arg Val Leu Arg Val Gly Ser Pro Glu Ser Ile
 1               5                  10                  15      
His Ile Gln Ala His Ser Asp Ser Arg Gln Pro Leu Thr Arg Thr Leu
            20                  25                  30          
Lys Val Asn Leu Thr Val Trp Asp Phe Pro Met Arg Lys Thr Val Leu
        35                  40                  45              
Ala Arg Ser Gln Leu Ile Leu Ser Pro Gly Asn Asn Phe Met Asp Gln
    50                  55                  60                  
Ala Pro Val Thr Val Pro Glu Ser Leu Met Tyr Leu Pro Lys Pro Gly
65                  70                  75                  80  
Gln Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser
                85                  90                  95      
Ser Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile
            100                 105                 110         
Phe Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His
        115                 120                 125             
Tyr Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr
    130                 135                 140                 
Phe Thr Leu Asp Ile Lys Val Val Phe Pro Asp Glu Gly Cys Pro Cys
145                 150                 155                 160 
Gln Val Trp Glu Pro Glu Gly Trp Gln Arg Arg Leu Ser Phe Ser Val
                165                 170                 175     
Ser Ile Ser Leu Asn Phe Leu Cys Leu Ser Leu Gly Thr Trp Thr Ile
            180                 185                 190         
Glu Ala Ser Tyr Gln Ser Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe
        195                 200                 205             
Asp Val Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Gln Leu Val Pro
    210                 215                 220                 
Asn Lys Thr Phe Phe Tyr Leu Lys Asp Glu Ala Leu Gly Val Asp Ile
225                 230                 235                 240 
Gln Ala Arg Gln Trp Asn Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn
                245                 250                 255     
Lys Pro Val Asp Gly His Ala Leu Val Ile Phe Gly Val Lys Leu Asp
            260                 265                 270         
Ser Cys Arg Ile Pro Ile Gln Ser Ser Leu Gln Arg Val Glu Ile Ser
        275                 280                 285             
Glu Gly Leu Gly His Val Ser Leu Gln Lys Asp Thr Leu Met Ala Ala
    290                 295                 300                 
Phe Gln Gly Pro Gly Glu Asp Phe Ile Gly Gly Ser Ile Phe Val Asn
305                 310                 315                 320 
Val Thr Met Phe Ser Ser Gly Gly Glu Met Val Gln Ala Glu Thr Ser
                325                 330                 335     
Gly Val Lys Ile Ile Gln Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr
            340                 345                 350         
Pro Gln Tyr Phe Lys Pro Gly Met Pro Phe His Phe Arg Val Phe Ile
        355                 360                 365             
Ser Asn Pro Asp Gly Ser Pro Ala Ser Arg Val Leu Val His Ser Gln
    370                 375                 380                 
Asp Gln Lys Val Tyr Thr Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile
385                 390                 395                 400 
Asn Thr Asp Ala Asn Leu Asp Lys Leu Pro Ile Glu Val Lys Thr Glu
                405                 410                 415     
Glu Ser Leu Gln Pro Glu Glu Gln Ala Ser Ala Lys Met Thr Ala Trp
            420                 425                 430         
Pro Tyr Leu Thr Gln Asp Gly Ser Gly Asn Phe Leu His Ile Glu Val
        435                 440                 445             
Lys Thr Leu Gly Thr Glu Val Gly Ser Ser Ile Gln Leu Ser Leu Asn
    450                 455                 460                 
Thr Arg His Gln Asp Pro Lys Thr Lys Asp Lys Ile Thr His Phe Thr
465                 470                 475                 480 
Ile Leu Val Leu Ser Lys Gly Gln Thr Val Ser Ala Lys His Gln Ser
                485                 490                 495     
Lys Ser Gln Gly Ser Val Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser
            500                 505                 510         
Ala Met Leu Pro Ser Phe Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg
        515                 520                 525             
Gly Ala Ser Gln Asp Pro Glu Leu Val Ala Asp Ser Ile Trp Ile Asp
    530                 535                 540                 
Val Asn Asp Arg Cys Ile Gly Met Leu Lys Val Gly Leu Lys Asn Asp
545                 550                 555                 560 
Arg Phe Phe Gln Ser Leu Glu Pro Asn Ser Gln Val Glu Leu Lys Val
                565                 570                 575     
Thr Gly Asp Ala Glu Ala Thr Val Gly Leu Val Ala Val Asp Lys Ala
            580                 585                 590         
Val Tyr Val Leu Asn Ser Lys His Lys Leu Thr Gln Lys Lys Val Trp
        595                 600                 605             
Asn Val Val Glu Glu His Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys
    610                 615                 620                 
Asp Arg Phe Ala Val Phe Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser
625                 630                 635                 640 
Thr Gly Met Asp Ser Leu Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp
                645                 650                 655     
Gly Lys Arg Arg Ala Glu Met Val Asn Lys Phe Lys Thr Glu Leu Glu
            660                 665                 670         
Gln Lys Cys Cys Glu Ala Gly Leu Arg Glu Ser Pro Val Gly Leu Ser
        675                 680                 685             
Cys Glu Glu Arg Thr Trp His Val Arg His Gly Pro Ala Cys Val Ala
    690                 695                 700                 
Ala Phe Leu Asp Cys Cys His Leu Ser Glu Thr Leu Thr Arg Glu Ala
705                 710                 715                 720 
Arg Glu Asp Gln Leu His Leu Trp Thr Lys Asp Phe Asp Asp Leu Phe
                725                 730                 735     
Leu Asp Asp Met Pro Val Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp
            740                 745                 750         
Arg Lys Phe Thr Leu Pro Lys Ser Lys Ser Gly Ile Ser His Tyr Pro
        755                 760                 765             
Ile Ser Val Lys Val Pro Asp Ser Ile Thr Thr Trp Gln Phe Val Val
    770                 775                 780                 
Val Ser Leu Lys Ala Gly Gln Gly Leu Cys Val Ser Asp Pro Phe Glu
785                 790                 795                 800 
Leu Thr Val Met Lys Ser Phe Phe Val Asp Leu Lys Leu Pro Ser Ser
                805                 810                 815     
Val Ile Arg Asn Glu Gln Val Gln Ile Gln Ala Met Leu Tyr Asn Phe
            820                 825                 830         
Arg Asp Arg Gln Ala Lys Val Arg Val Glu Phe Pro His Lys Glu Thr
        835                 840                 845             
Leu Cys Ser Ala Ser Lys Pro Gly Ala Pro Ser His Gln Val Val Val
    850                 855                 860                 
Val Pro Pro Thr Ser Ser Lys Ile Val His Phe Val Leu Leu Pro Leu
865                 870                 875                 880 
Glu Thr Gly Lys Val Asp Val Glu Val Lys Ala Val Gly Tyr Gly Val
                885                 890                 895     
Gln Asp His Val Lys Lys Thr Leu Leu Val Arg Val Met Gly Thr Pro
            900                 905                 910         
Asn Ser Leu Ala Ala Gly Ala Asp Ser Gly Ala Ser Thr Arg Ser Arg
        915                 920                 925             
Leu Gly Arg Arg Ser Arg Val Gly Arg Ser Val Asn His Cys Gly Leu
    930                 935                 940                 
Ser Ile Ala Thr Pro Arg Val Thr Gln Leu Thr His Leu Thr Gly Asp
945                 950                 955                 960 
Ile Leu Gly Glu Thr Ile Val Gly Ser Leu Thr Pro Ser Glu Ile Gln
                965                 970                 975     
Gln Leu Leu Arg Val Pro Thr Gly Cys Pro Glu Gln Thr Leu Ser Ser
            980                 985                 990         
Leu Thr Pro Val Ile Ile Leu Ser Arg Tyr Leu Asp Thr Thr Gly Gln
        995                 1000                1005            
Trp Gly Lys Val Gly Val Glu His Arg Asp Gln Val Met Lys Asn Ile
    1010                1015                1020                
Val Ser Gly Tyr Thr Gln Met Leu Thr His Arg Ser Ser Asp Gly Thr
1025                1030                1035                1040
Tyr His Thr Ser Lys Gly Asn Pro Gly Ser Thr Trp Leu Thr Ser Tyr
                1045                1050                1055    
Val Phe Arg Val Phe Ala Leu Ala Tyr Ser Met Met Thr Thr Gln Val
            1060                1065                1070        
Leu Ser Leu Ser Ser Leu Cys Asp Met Ala Asn Trp Ile Ile Ile Asp
        1075                1080                1085            
Arg Gln Ala Glu Asp Gly His Phe Leu Glu Lys Gly Pro Val Val Met
    1090                1095                1100                
Thr Ser Met Gln Asp Gly Tyr Gln Gly Ser Glu Glu Asp Val Ser Leu
1105                1110                1115                1120
Thr Ala Leu Val Leu Ile Ala Leu Asn Glu Gly Lys Glu Leu Cys Arg
                1125                1130                1135    
Gln Lys Val Gly Pro Gln Arg Gly Gly Gln Asp Leu Ile Glu Arg Ala
            1140                1145                1150        
Arg Gly Phe Leu Glu Arg Lys Leu Pro Asp Ile Gln Thr Thr Phe Ala
        1155                1160                1165            
Val Ala Ile Ala Ser Tyr Ala Leu Ala Leu Ala Asn Ser Ser Gln Ala
    1170                1175                1180                
Asn Asp Cys Leu Asp Ser Phe Ala Ser Pro Asn Lys Thr His Trp Pro
1185                1190                1195                1200
Val Asp Glu Gln Asn Leu Gly Ser Leu Tyr Thr Ile Glu Ala Thr Ala
                1205                1210                1215    
Tyr Gly Leu Met Gln Lys Leu Glu Leu Gly Arg Tyr Asn Glu Thr His
            1220                1225                1230        
Ala Ile Ala Lys Trp Leu Leu Glu Lys Gln Glu Leu Gly Gly Gly Phe
        1235                1240                1245            
Arg Ser Thr Gln
    1250        


<210> 7046
<211> 1511
<212> PRT
<213> Homo sapiens

<400> 7046
Gln Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser
 1               5                  10                  15      
Ser Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile
            20                  25                  30          
Phe Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His
        35                  40                  45              
Tyr Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr
    50                  55                  60                  
Phe Thr Leu Asp Ile Lys Asn Pro Lys Gly Ile Thr Val Ile Ser Gln
65                  70                  75                  80  
Ser Leu Met Ala Lys Asp Gly Phe Phe Phe Ser Ser Phe His Leu Pro
                85                  90                  95      
Glu Leu Val Ser Leu Gly Thr Trp Thr Ile Glu Ala Ser Tyr Gln Ser
            100                 105                 110         
Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp Val Lys Glu Tyr Val
        115                 120                 125             
Leu Pro Ser Phe Glu Val Gln Leu Val Pro Asn Lys Thr Phe Phe Tyr
    130                 135                 140                 
Leu Lys Asp Glu Ala Leu Gly Val Asp Ile Gln Ala Arg Gln Trp Asn
145                 150                 155                 160 
Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn Lys Pro Val Asp Gly His
                165                 170                 175     
Ala Leu Val Ile Phe Gly Val Lys Leu Asp Ser Cys Arg Ile Pro Ile
            180                 185                 190         
Gln Ser Ser Leu Gln Arg Val Glu Ile Ser Glu Gly Leu Gly His Val
        195                 200                 205             
Ser Leu Gln Lys Asp Thr Leu Met Ala Ala Phe Gln Gly Pro Gly Glu
    210                 215                 220                 
Asp Phe Ile Gly Gly Ser Ile Phe Val Asn Val Thr Met Phe Ser Ser
225                 230                 235                 240 
Gly Gly Glu Met Val Gln Ala Glu Thr Ser Gly Val Lys Ile Ile Gln
                245                 250                 255     
Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro Gln Tyr Phe Lys Pro
            260                 265                 270         
Gly Met Pro Phe His Phe Arg Val Phe Ile Ser Asn Pro Asp Gly Ser
        275                 280                 285             
Pro Ala Ser Arg Val Leu Val His Ser Gln Asp Gln Lys Val Tyr Thr
    290                 295                 300                 
Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn Thr Asp Ala Asn Leu
305                 310                 315                 320 
Asp Lys Leu Pro Ile Glu Val Lys Thr Glu Glu Ser Leu Gln Pro Glu
                325                 330                 335     
Glu Gln Ala Ser Ala Lys Met Thr Ala Trp Pro Tyr Leu Thr Gln Asp
            340                 345                 350         
Gly Ser Gly Asn Phe Leu His Ile Glu Val Lys Thr Leu Gly Thr Glu
        355                 360                 365             
Val Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr Arg His Gln Asp Pro
    370                 375                 380                 
Lys Thr Lys Asp Lys Ile Thr His Phe Thr Ile Leu Val Leu Ser Lys
385                 390                 395                 400 
Gly Gln Thr Val Ser Ala Lys His Gln Ser Lys Ser Gln Gly Ser Val
                405                 410                 415     
Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser Ala Met Leu Pro Ser Phe
            420                 425                 430         
Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly Ala Ser Gln Asp Pro
        435                 440                 445             
Glu Leu Val Ala Asp Ser Ile Trp Ile Asp Val Asn Asp Arg Cys Ile
    450                 455                 460                 
Gly Met Leu Lys Val Gly Leu Lys Asn Asp Arg Phe Phe Gln Ser Leu
465                 470                 475                 480 
Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly Asp Ala Glu Ala
                485                 490                 495     
Thr Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr Val Leu Asn Ser
            500                 505                 510         
Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn Val Val Glu Glu His
        515                 520                 525             
Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg Phe Ala Val Phe
    530                 535                 540                 
Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly Met Asp Ser Leu
545                 550                 555                 560 
Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly Lys Arg Arg Ala Glu
                565                 570                 575     
Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln Lys Cys Cys Glu Ala
            580                 585                 590         
Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys Glu Glu Arg Thr Trp
        595                 600                 605             
His Val Arg His Gly Pro Ala Cys Val Ala Ala Phe Leu Asp Cys Cys
    610                 615                 620                 
His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg Glu Asp Gln Leu His
625                 630                 635                 640 
Leu Trp Thr Thr Asp Glu Glu Glu Asp Phe Asp Asp Leu Phe Leu Asp
                645                 650                 655     
Asp Met Pro Val Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp Arg Lys
            660                 665                 670         
Phe Thr Leu Pro Lys Ser Lys Ser Gly Ile Ser His Tyr Pro Ile Ser
        675                 680                 685             
Val Lys Val Pro Asp Ser Ile Thr Thr Trp Gln Phe Val Val Val Ser
    690                 695                 700                 
Leu Lys Ala Gly Gln Gly Leu Cys Val Ser Asp Pro Phe Glu Leu Thr
705                 710                 715                 720 
Val Met Lys Ser Phe Phe Val Asp Leu Lys Leu Pro Ser Ser Val Ile
                725                 730                 735     
Arg Asn Glu Gln Val Gln Ile Gln Ala Met Leu Tyr Asn Phe Arg Asp
            740                 745                 750         
Arg Gln Ala Lys Val Arg Val Glu Phe Pro His Lys Glu Thr Leu Cys
        755                 760                 765             
Ser Ala Ser Lys Pro Gly Ala Pro Ser His Gln Val Val Val Val Pro
    770                 775                 780                 
Pro Thr Ser Ser Lys Ile Val His Phe Val Leu Leu Pro Leu Glu Thr
785                 790                 795                 800 
Gly Lys Val Asp Val Glu Val Lys Ala Val Gly Tyr Gly Val Gln Asp
                805                 810                 815     
His Val Lys Lys Thr Leu Leu Val Arg Val Met Gly Thr Pro Asn Ser
            820                 825                 830         
Leu Ala Ala Gly Ala Asp Ser Gly Ala Ser Thr Arg Ser Arg Leu Gly
        835                 840                 845             
Arg Val Thr Gln Leu Thr His Leu Thr Gly Asp Ile Leu Gly Glu Thr
    850                 855                 860                 
Ile Val Gly Ser Leu Thr Pro Ser Glu Ile Gln Gln Leu Leu Arg Val
865                 870                 875                 880 
Pro Thr Gly Cys Pro Glu Gln Thr Leu Ser Ser Leu Thr Pro Val Ile
                885                 890                 895     
Ile Leu Ser Arg Tyr Leu Asp Thr Thr Gly Gln Trp Gly Lys Val Gly
            900                 905                 910         
Val Glu His Arg Asp Gln Val Met Lys Asn Ile Val Ser Gly Tyr Thr
        915                 920                 925             
Gln Met Leu Thr His Arg Ser Ser Asp Gly Thr Tyr His Thr Ser Lys
    930                 935                 940                 
Gly Asn Pro Gly Ser Thr Trp Leu Thr Ser Tyr Val Phe Arg Val Phe
945                 950                 955                 960 
Ala Leu Ala Tyr Ser Met Met Thr Thr Gln Val Leu Ser Leu Ser Ser
                965                 970                 975     
Leu Cys Asp Met Ala Asn Trp Ile Ile Ile Asp Arg Gln Ala Glu Asp
            980                 985                 990         
Gly His Phe Leu Glu Lys Gly Pro Val Val Met Thr Ser Met Gln Asp
        995                 1000                1005            
Gly Tyr Gln Gly Ser Glu Glu Asp Val Ser Leu Thr Ala Leu Val Leu
    1010                1015                1020                
Ile Ala Leu Asn Glu Gly Lys Glu Leu Cys Arg Gln Lys Val Gly Pro
1025                1030                1035                1040
Gln Arg Gly Gly Gln Asp Leu Ile Glu Arg Ala Arg Gly Phe Leu Glu
                1045                1050                1055    
Arg Lys Leu Pro Asp Ile Gln Thr Thr Phe Ala Val Ala Ile Ala Ser
            1060                1065                1070        
Tyr Ala Leu Ala Leu Ala Asn Ser Ser Gln Ala Asn Asp Cys Leu Asp
        1075                1080                1085            
Ser Phe Ala Ser Pro Ser Gly Tyr Lys Thr His Trp Pro Val Asp Glu
    1090                1095                1100                
Gln Asn Leu Gly Ser Leu Tyr Thr Ile Glu Ala Thr Ala Tyr Gly Leu
1105                1110                1115                1120
Met Gln Lys Leu Glu Leu Gly Arg Tyr Asn Glu Thr His Ala Ile Ala
                1125                1130                1135    
Lys Trp Leu Leu Glu Lys Gln Glu Leu Gly Gly Gly Phe Arg Ser Thr
            1140                1145                1150        
Gln Thr Thr Val Val Ala Leu Glu Ala Leu Thr Arg Phe Arg Glu Ala
        1155                1160                1165            
Val Pro Phe Lys Gly Ile Gln Asp Leu His Val Gln Ile Arg Ala Pro
    1170                1175                1180                
Lys Thr Ala Leu Asn Val Asn Trp Tyr Ile Asp His Ser Asn Ala Tyr
1185                1190                1195                1200
Gln Gln Arg Phe Leu Leu Ala Lys Ala Leu Cys Cys Glu Trp Gln Arg
                1205                1210                1215    
Gly His Gly Glu Thr Trp Lys Glu Ala Thr Ala Leu Val Gln Ala Arg
            1220                1225                1230        
Asp Asn Ser Ser Gly Glu His Gly Glu Arg Gly Gly Arg Ile Val Gly
        1235                1240                1245            
Lys Asp Trp Gly Cys Glu Leu Pro Gly Ser Arg Thr Glu Ala Thr Met
    1250                1255                1260                
Thr Ile Met Glu Val Ser Leu Leu Thr Gly Phe Tyr Pro Asn Gln Asp
1265                1270                1275                1280
Asp Leu Lys Gln Leu Thr Ser Asp Val Glu Arg Tyr Ala Phe Gln Tyr
                1285                1290                1295    
Lys Thr Lys Thr Ser Thr Ser Asp Ser Thr Val Val Leu Tyr Leu Glu
            1300                1305                1310        
Lys Leu Ser His Glu Lys Asn Thr Val Leu Gly Phe Arg Val His Arg
        1315                1320                1325            
Met Leu Gln Ala Glu Phe Leu Gln Ala Ala Leu Val Thr Ile Tyr Asp
    1330                1335                1340                
Tyr Tyr Glu Pro Ser Arg Arg Cys Ser Thr Phe Tyr Asn Leu Pro Thr
1345                1350                1355                1360
Glu Gln Ser Ser Leu Arg Lys Ile Cys His Lys Asp Ile Cys Arg Cys
                1365                1370                1375    
Ala Glu Gly Gln Cys Pro Ser Leu Gln Lys Pro Ser Gly Gln Leu Arg
            1380                1385                1390        
Gln Glu Glu Leu Gln Thr Thr Ala Cys Glu Ala Gly Val Asp Phe Val
        1395                1400                1405            
Tyr Lys Thr Lys Leu Glu Ser Val Glu Val Ser Ala Ser Asn Pro Tyr
    1410                1415                1420                
Val Tyr Tyr Asn Thr Gln Leu Glu Asp Ile Ile Lys Ser Gly Thr Asp
1425                1430                1435                1440
Pro Ala Thr Pro Leu Ala Met Lys Lys Phe Val Ser His Ala Thr Cys
                1445                1450                1455    
His Asp Ser Leu Gly Leu Gln Glu Gln Glu Ser Tyr Leu Ile Met Gly
            1460                1465                1470        
Gln Thr Ser Asp Leu Trp Arg Ile Lys Ser Asp Tyr Ser Tyr Val Leu
        1475                1480                1485            
Gly Lys Glu Thr Phe Leu Ile Leu Trp Pro Ala Asp Gly Asp Ala Ser
    1490                1495                1500                
Lys Lys Glu Leu Arg Asp Gln
1505                1510    


<210> 7047
<211> 1216
<212> PRT
<213> Homo sapiens

<400> 7047
Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile Phe Ile
 1               5                  10                  15      
Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His Tyr Arg
            20                  25                  30          
Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr Phe Thr
        35                  40                  45              
Leu Asp Ile Lys Asn Pro Lys Gly Ile Thr Val Ile Ser Gln Ser Leu
    50                  55                  60                  
Met Ala Lys Asp Gly Phe Phe Phe Ser Ser Phe His Leu Pro Glu Leu
65                  70                  75                  80  
Val Arg Cys Pro Cys Gln Val Trp Glu Pro Glu Gly Trp Gln Arg Arg
                85                  90                  95      
Leu Ser Phe Ser Val Ser Ile Ser Leu Asn Phe Leu Cys Leu Ser Leu
            100                 105                 110         
Gly Thr Trp Thr Ile Glu Ala Ser Tyr Gln Ser Thr Pro Lys Gln Lys
        115                 120                 125             
Phe Glu Ala Ala Phe Asp Val Lys Glu Tyr Val Leu Pro Ser Phe Glu
    130                 135                 140                 
Val Gln Leu Val Pro Asn Lys Thr Phe Phe Tyr Leu Lys Asp Glu Ala
145                 150                 155                 160 
Leu Gly Val Asp Ile Gln Ala Arg Gln Trp Asn Cys Pro Pro Ser Pro
                165                 170                 175     
Thr Tyr Ile Phe Asn Lys Pro Val Asp Gly His Ala Leu Val Ile Phe
            180                 185                 190         
Gly Val Lys Leu Asp Ser Cys Arg Ile Pro Ile Gln Ser Ser Leu Gln
        195                 200                 205             
Arg Val Glu Ile Ser Glu Gly Leu Gly His Val Ser Leu Gln Lys Asp
    210                 215                 220                 
Thr Leu Met Ala Ala Phe Gln Gly Pro Gly Glu Asp Phe Ile Gly Gly
225                 230                 235                 240 
Ser Ile Phe Val Asn Val Thr Met Phe Ser Ser Gly Gly Glu Met Val
                245                 250                 255     
Gln Ala Glu Thr Ser Gly Val Lys Ile Ile Gln Ser Pro Tyr Asn Ile
            260                 265                 270         
Lys Phe Thr Arg Thr Pro Gln Tyr Phe Lys Pro Gly Met Pro Phe His
        275                 280                 285             
Phe Arg Val Phe Ile Ser Asn Pro Asp Gly Ser Pro Ala Ser Arg Val
    290                 295                 300                 
Leu Val His Ser Gln Asp Gln Lys Val Tyr Thr Ser Ala Glu Gly Leu
305                 310                 315                 320 
Ala Thr Leu Thr Ile Asn Thr Asp Ala Asn Leu Asp Lys Leu Pro Ile
                325                 330                 335     
Glu Val Lys Thr Glu Glu Ser Leu Gln Pro Glu Glu Gln Ala Ser Ala
            340                 345                 350         
Lys Met Thr Ala Trp Pro Tyr Leu Thr Gln Asp Gly Ser Gly Asn Phe
        355                 360                 365             
Leu His Ile Glu Val Lys Thr Leu Gly Thr Glu Val Gly Ser Ser Ile
    370                 375                 380                 
Gln Leu Ser Leu Asn Thr Arg His Gln Asp Pro Lys Thr Lys Asp Lys
385                 390                 395                 400 
Ile Thr His Phe Thr Ile Leu Val Leu Ser Lys Gly Gln Thr Val Ser
                405                 410                 415     
Ala Lys His Gln Ser Lys Ser Gln Gly Ser Val Tyr Thr Ser Ala Ile
            420                 425                 430         
Ile Asp Val Thr Ser Ala Met Leu Pro Ser Phe Arg Ile Leu Ala Phe
        435                 440                 445             
Tyr Leu Leu Pro Arg Gly Ala Ser Gln Asp Pro Glu Leu Val Ala Asp
    450                 455                 460                 
Ser Ile Trp Ile Asp Val Asn Asp Arg Cys Ile Gly Met Val Ser Gln
465                 470                 475                 480 
Thr Pro Cys Ser Trp Lys Arg Arg Arg Ile Cys Gly Leu Lys Ser Ser
                485                 490                 495     
Thr Gln Gly Val Ala Val Met Gln Val Asn Lys Tyr Thr Glu Leu Gly
            500                 505                 510         
Leu Ser Gly Val Pro Arg Cys Ser Thr Arg Ala Val Gly Asn Val Ser
        515                 520                 525             
Leu Cys Ser Cys Val Val Tyr Asp Ser Leu Phe Leu Thr Ser Leu Phe
    530                 535                 540                 
Phe Leu Ala Gln Leu Lys Val Gly Leu Lys Asn Asp Arg Phe Phe Gln
545                 550                 555                 560 
Ser Leu Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly Asp Ala
                565                 570                 575     
Glu Ala Thr Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr Val Leu
            580                 585                 590         
Asn Ser Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn Val Val Glu
        595                 600                 605             
Glu His Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg Phe Ala
    610                 615                 620                 
Val Phe Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly Met Asp
625                 630                 635                 640 
Ser Leu Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly Lys Arg Arg
                645                 650                 655     
Ala Glu Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln Lys Cys Cys
            660                 665                 670         
Glu Ala Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys Glu Glu Arg
        675                 680                 685             
Thr Trp His Val Arg His Gly Pro Ala Cys Val Ala Ala Phe Leu Asp
    690                 695                 700                 
Cys Cys His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg Glu Asp Gln
705                 710                 715                 720 
Leu His Leu Trp Thr Lys Glu Asp Phe Asp Asp Leu Phe Leu Asp Asp
                725                 730                 735     
Met Pro Val Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp Arg Lys Phe
            740                 745                 750         
Thr Leu Pro Lys Ser Lys Ser Gly Ile Ser His Tyr Pro Ile Ser Val
        755                 760                 765             
Lys Val Pro Asp Ser Ile Thr Thr Trp Gln Phe Val Val Val Ser Leu
    770                 775                 780                 
Lys Ala Gly Gln Gly Leu Cys Val Ser Asp Pro Phe Glu Leu Thr Val
785                 790                 795                 800 
Met Lys Ser Phe Phe Val Asp Leu Lys Leu Pro Ser Ser Val Ile Arg
                805                 810                 815     
Asn Glu Gln Val Gln Ile Gln Ala Met Leu Tyr Asn Phe Arg Asp Arg
            820                 825                 830         
Gln Ala Lys Val Arg Val Glu Phe Pro His Lys Glu Thr Leu Cys Ser
        835                 840                 845             
Ala Ser Lys Pro Gly Ala Pro Ser His Gln Val Val Val Val Pro Pro
    850                 855                 860                 
Thr Ser Ser Lys Ile Val His Phe Val Leu Leu Pro Leu Glu Thr Gly
865                 870                 875                 880 
Lys Val Asp Val Glu Val Lys Ala Val Gly Tyr Gly Val Gln Asp His
                885                 890                 895     
Val Lys Lys Thr Leu Leu Val Arg Val Met Gly Thr Pro Asn Ser Leu
            900                 905                 910         
Ala Ala Gly Ala Asp Ser Gly Ala Ser Thr Arg Ser Arg Leu Gly Arg
        915                 920                 925             
Val Thr Gln Leu Thr His Leu Thr Gly Asp Ile Leu Gly Glu Thr Ile
    930                 935                 940                 
Val Gly Ser Leu Thr Pro Ser Glu Ile Gln Gln Leu Leu Arg Val Pro
945                 950                 955                 960 
Thr Gly Cys Pro Glu Gln Thr Leu Ser Ser Leu Thr Pro Val Ile Ile
                965                 970                 975     
Leu Ser Arg Tyr Leu Asp Thr Thr Gly Gln Trp Gly Lys Val Gly Val
            980                 985                 990         
Glu His Arg Asp Gln Val Met Lys Asn Ile Val Ser Gly Tyr Thr Gln
        995                 1000                1005            
Met Leu Thr His Arg Ser Ser Asp Gly Thr Tyr His Thr Ser Lys Gly
    1010                1015                1020                
Asn Pro Gly Ser Thr Trp Leu Thr Ser Tyr Val Phe Arg Val Phe Ala
1025                1030                1035                1040
Leu Ala Tyr Ser Met Met Thr Thr Gln Val Leu Ser Leu Ser Ser Leu
                1045                1050                1055    
Cys Asp Met Ala Asn Trp Ile Ile Ile Asp Arg Gln Ala Glu Asp Gly
            1060                1065                1070        
His Phe Leu Glu Lys Gly Pro Val Val Met Thr Ser Met Gln Asp Gly
        1075                1080                1085            
Tyr Gln Gly Ser Glu Glu Asp Val Ser Leu Thr Ala Leu Val Leu Ile
    1090                1095                1100                
Ala Leu Asn Glu Gly Lys Glu Leu Cys Arg Gln Lys Val Gly Pro Gln
1105                1110                1115                1120
Arg Gly Gly Gln Asp Leu Ile Glu Arg Ala Arg Gly Phe Leu Glu Arg
                1125                1130                1135    
Lys Leu Pro Asp Ile Gln Thr Thr Phe Ala Val Ala Ile Ala Ser Tyr
            1140                1145                1150        
Ala Leu Ala Leu Ala Asn Ser Ser Gln Ala Asn Asp Cys Leu Asp Ser
        1155                1160                1165            
Phe Ala Ser Pro Asn Lys Thr His Trp Pro Val Asp Glu Gln Asn Leu
    1170                1175                1180                
Gly Ser Leu Tyr Thr Ile Glu Ala Thr Ala Tyr Gly Leu Met Gln Lys
1185                1190                1195                1200
Leu Glu Leu Gly Arg Tyr Asn Glu Thr His Ala Ile Ala Lys Trp Leu
                1205                1210                1215    


<210> 7048
<211> 1587
<212> PRT
<213> Homo sapiens

<400> 7048
Ile Leu Leu Leu Leu Gly Ser Pro Leu Ile His Ala Glu Pro Leu Tyr
 1               5                  10                  15      
Ile Leu Val Thr Pro Arg Val Leu Arg Val Gly Ser Pro Glu Ser Ile
            20                  25                  30          
His Ile Gln Ala His Ser Asp Ser Arg Gln Pro Leu Thr Arg Thr Leu
        35                  40                  45              
Lys Val Asn Leu Thr Val Trp Asp Phe Pro Met Arg Lys Thr Val Leu
    50                  55                  60                  
Ala Arg Ser Gln Leu Ile Leu Ser Pro Gly Asn Asn Phe Met Asp Gln
65                  70                  75                  80  
Ala Pro Val Thr Val Pro Glu Ser Leu Met Tyr Leu Pro Lys Pro Gly
                85                  90                  95      
Gln Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser
            100                 105                 110         
Ser Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile
        115                 120                 125             
Phe Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His
    130                 135                 140                 
Tyr Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr
145                 150                 155                 160 
Phe Thr Leu Asp Ile Lys Asn Pro Lys Gly Ile Thr Val Ile Ser Gln
                165                 170                 175     
Ser Leu Met Ala Lys Asp Gly Phe Phe Phe Ser Ser Phe His Leu Pro
            180                 185                 190         
Glu Leu Val Ser Leu Gly Thr Trp Thr Ile Glu Ala Ser Tyr Gln Ser
        195                 200                 205             
Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp Val Lys Glu Tyr Val
    210                 215                 220                 
Leu Pro Ser Phe Glu Val Gln Leu Val Pro Asn Lys Thr Phe Phe Tyr
225                 230                 235                 240 
Leu Lys Asp Glu Ala Leu Gly Val Asp Ile Gln Ala Arg Gln Trp Asn
                245                 250                 255     
Cys Pro Pro Ser Pro Thr Tyr Ile Phe Asn Lys Pro Val Asp Gly His
            260                 265                 270         
Ala Leu Val Ile Phe Gly Val Lys Leu Asp Ser Cys Arg Ile Pro Ile
        275                 280                 285             
Gln Ser Ser Leu Gln Arg Val Glu Ile Ser Glu Gly Leu Gly His Val
    290                 295                 300                 
Ser Leu Gln Lys Asp Thr Leu Met Ala Ala Phe Gln Gly Pro Gly Glu
305                 310                 315                 320 
Asp Phe Ile Gly Gly Ser Ile Phe Val Asn Val Thr Met Phe Ser Ser
                325                 330                 335     
Gly Gly Glu Met Val Gln Ala Glu Thr Ser Gly Val Lys Ile Ile Gln
            340                 345                 350         
Ser Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro Gln Tyr Phe Lys Pro
        355                 360                 365             
Gly Met Pro Phe His Phe Arg Val Phe Ile Ser Asn Pro Asp Gly Ser
    370                 375                 380                 
Pro Ala Ser Arg Val Leu Val His Ser Gln Asp Gln Lys Val Tyr Thr
385                 390                 395                 400 
Ser Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn Thr Asp Ala Asn Leu
                405                 410                 415     
Asp Lys Leu Pro Ile Glu Val Lys Thr Glu Glu Ser Leu Gln Pro Glu
            420                 425                 430         
Glu Gln Ala Ser Ala Lys Met Thr Ala Trp Pro Tyr Leu Thr Gln Asp
        435                 440                 445             
Gly Ser Gly Asn Phe Leu His Ile Glu Val Lys Thr Leu Gly Thr Glu
    450                 455                 460                 
Val Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr Arg His Gln Asp Pro
465                 470                 475                 480 
Lys Thr Lys Asp Lys Ile Thr His Phe Thr Ile Leu Val Leu Ser Lys
                485                 490                 495     
Gly Gln Thr Val Ser Ala Lys His Gln Ser Lys Ser Gln Gly Ser Val
            500                 505                 510         
Tyr Thr Ser Ala Ile Ile Asp Val Thr Ser Ala Met Leu Pro Ser Phe
        515                 520                 525             
Arg Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly Ala Ser Gln Asp Pro
    530                 535                 540                 
Glu Leu Val Ala Asp Ser Ile Trp Ile Asp Val Asn Asp Arg Cys Ile
545                 550                 555                 560 
Gly Met Leu Lys Val Gly Leu Lys Asn Asp Arg Phe Phe Gln Ser Leu
                565                 570                 575     
Glu Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly Asp Ala Glu Ala
            580                 585                 590         
Thr Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr Val Leu Asn Ser
        595                 600                 605             
Lys His Lys Leu Thr Gln Lys Lys Val Trp Asn Val Val Glu Glu His
    610                 615                 620                 
Asp Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg Phe Ala Val Phe
625                 630                 635                 640 
Lys Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly Met Asp Ser Leu
                645                 650                 655     
Ala Ser Ser Gly Thr Gly Phe Gly Gly Trp Gly Lys Arg Arg Ala Glu
            660                 665                 670         
Met Val Asn Lys Phe Lys Thr Glu Leu Glu Gln Lys Cys Cys Glu Ala
        675                 680                 685             
Gly Leu Arg Glu Ser Pro Val Gly Leu Ser Cys Glu Glu Arg Thr Trp
    690                 695                 700                 
His Val Arg His Gly Pro Ala Cys Val Ala Ala Phe Leu Asp Cys Cys
705                 710                 715                 720 
His Leu Ser Glu Thr Leu Thr Arg Glu Ala Arg Glu Asp Gln Leu His
                725                 730                 735     
Leu Trp Thr Lys Asp Phe Asp Asp Leu Phe Leu Asp Asp Met Pro Val
            740                 745                 750         
Arg Thr Leu Phe Pro Glu Ser Trp Leu Trp Arg Lys Phe Thr Leu Pro
        755                 760                 765             
Lys Ser Lys Ser Gly Ile Ser His Tyr Pro Ile Ser Val Lys Val Pro
    770                 775                 780                 
Asp Ser Ile Thr Thr Trp Gln Phe Val Val Val Ser Leu Lys Ala Gly
785                 790                 795                 800 
Gln Gly Leu Cys Val Ser Asp Pro Phe Glu Leu Thr Val Met Lys Ser
                805                 810                 815     
Phe Phe Val Asp Leu Lys Leu Pro Ser Ser Val Ile Arg Asn Glu Gln
            820                 825                 830         
Val Gln Ile Gln Ala Met Leu Tyr Asn Phe Arg Asp Arg Gln Ala Lys
        835                 840                 845             
Val Arg Val Glu Phe Pro His Lys Glu Thr Leu Cys Ser Ala Ser Lys
    850                 855                 860                 
Pro Gly Ala Pro Ser His Gln Val Val Val Val Pro Pro Thr Ser Ser
865                 870                 875                 880 
Lys Ile Val His Phe Val Leu Leu Pro Leu Glu Thr Gly Lys Val Asp
                885                 890                 895     
Val Glu Val Lys Ala Val Gly Tyr Gly Val Gln Asp His Val Lys Lys
            900                 905                 910         
Thr Leu Leu Val Arg Val Met Gly Thr Pro Asn Ser Leu Ala Ala Gly
        915                 920                 925             
Ala Asp Ser Gly Ala Ser Thr Ser Pro Leu Val Thr Glu Gly Cys Gly
    930                 935                 940                 
Tyr Ser Gly Gln Thr Gln Thr Lys Leu Val Pro Arg Gln Glu Phe Leu
945                 950                 955                 960 
Asn Met Val Pro Asp Thr Glu Ala Glu Val Phe Ile Ser Val Gln Gly
                965                 970                 975     
Asp Ile Leu Gly Glu Thr Ile Val Gly Ser Leu Thr Pro Ser Glu Ile
            980                 985                 990         
Gln Gln Leu Leu Arg Val Pro Thr Gly Cys Pro Glu Gln Thr Leu Ser
        995                 1000                1005            
Ser Leu Thr Pro Val Ile Ile Leu Ser Arg Tyr Leu Asp Thr Thr Gly
    1010                1015                1020                
Gln Trp Gly Lys Val Gly Val Glu His Arg Asp Gln Val Met Lys Asn
1025                1030                1035                1040
Ile Val Ser Gly Glu Ser Gly Asp Pro Pro Gly Ala Ser Lys Arg Val
                1045                1050                1055    
Ser Leu Leu Pro Ser Pro Asp Arg Leu Thr Ser Tyr Val Phe Arg Val
            1060                1065                1070        
Phe Ala Leu Ala Tyr Ser Met Met Thr Thr Gln Val Leu Ser Leu Ser
        1075                1080                1085            
Ser Leu Cys Asp Met Ala Asn Trp Ile Ile Ile Asp Arg Gln Ala Glu
    1090                1095                1100                
Asp Gly His Phe Leu Glu Lys Gly Pro Val Val Met Thr Ser Met Gln
1105                1110                1115                1120
Asp Gly Tyr Gln Gly Ser Glu Glu Asp Val Ser Leu Thr Ala Leu Val
                1125                1130                1135    
Leu Ile Ala Leu Asn Glu Gly Lys Glu Leu Cys Arg Gln Lys Val Gly
            1140                1145                1150        
Pro Gln Arg Gly Gly Gln Asp Leu Ile Glu Arg Ala Arg Gly Phe Leu
        1155                1160                1165            
Glu Arg Lys Leu Pro Asp Ile Gln Thr Thr Phe Ala Val Ala Ile Ala
    1170                1175                1180                
Ser Tyr Ala Leu Ala Leu Ala Asn Ser Ser Gln Ala Asn Asp Cys Leu
1185                1190                1195                1200
Asp Ser Phe Ala Ser Pro Met Asp Glu Gln Asn Leu Gly Ser Leu Tyr
                1205                1210                1215    
Thr Ile Glu Ala Thr Ala Tyr Gly Leu Met Gln Lys Leu Glu Leu Gly
            1220                1225                1230        
Arg Tyr Asn Glu Thr His Ala Ile Ala Lys Trp Leu Leu Glu Lys Gln
        1235                1240                1245            
Glu Leu Gly Gly Gly Phe Arg Ser Thr Gln Val Met Gly Thr Pro Gly
    1250                1255                1260                
Arg Phe Leu Leu Ala Lys Ala Leu Cys Cys Glu Trp Gln Arg Gly His
1265                1270                1275                1280
Gly Glu Thr Trp Lys Glu Ala Thr Ala Leu Val Gln Ala Arg Asp Asn
                1285                1290                1295    
Ser Ser Gly Glu His Gly Glu Arg Gly Gly Arg Ile Val Gly Lys Asp
            1300                1305                1310        
Trp Gly Cys Glu Leu Pro Gly Ser Arg Thr Ile Glu Ala Thr Met Thr
        1315                1320                1325            
Ile Met Glu Val Ser Leu Leu Thr Gly Phe Tyr Pro Asn Gln Asp Asp
    1330                1335                1340                
Leu Lys Gln Leu Thr Ser Asp Val Glu Arg Tyr Ala Phe Gln Tyr Lys
1345                1350                1355                1360
Thr Lys Thr Ser Thr Ser Asp Ser Thr Val Val Leu Tyr Leu Glu Lys
                1365                1370                1375    
Leu Ser His Glu Lys Asn Thr Val Leu Gly Phe Arg Val His Arg Met
            1380                1385                1390        
Leu Gln Ala Glu Phe Leu Gln Ala Ala Leu Val Thr Ile Tyr Asp Tyr
        1395                1400                1405            
Tyr Glu Pro Ser Arg Arg Cys Ser Thr Phe Tyr Asn Leu Pro Thr Glu
    1410                1415                1420                
Gln Ser Ser Leu Arg Lys Ile Cys His Lys Asp Ile Cys Arg Cys Ala
1425                1430                1435                1440
Glu Gly Gln Cys Pro Ser Leu Gln Lys Pro Ser Gly Gln Leu Arg Gln
                1445                1450                1455    
Glu Glu Leu Gln Thr Thr Ala Cys Glu Ala Gly Val Asp Phe Val Tyr
            1460                1465                1470        
Lys Thr Lys Leu Glu Ser Val Glu Val Ser Ala Ser Asn Pro Tyr Val
        1475                1480                1485            
Tyr Tyr Asn Thr Gln Leu Glu Asp Ile Ile Lys Ser Gly Thr Asp Pro
    1490                1495                1500                
Ala Thr Pro Leu Ala Met Lys Lys Phe Val Ser His Ala Thr Cys His
1505                1510                1515                1520
Asp Ser Leu Gly Leu Gln Glu Gln Glu Ser Tyr Leu Ile Met Gly Gln
                1525                1530                1535    
Thr Ser Asp Leu Trp Arg Ile Lys Ser Asp Tyr Ser Tyr Val Leu Gly
            1540                1545                1550        
Lys Glu Thr Phe Leu Ile Leu Trp Pro Ala Asp Gly Asp Ala Ser Lys
        1555                1560                1565            
Lys Glu Leu Arg Asp Gln Leu Glu Glu Phe Leu Glu Tyr Met Arg Thr
    1570                1575                1580                
His Gly Cys
1585        


<210> 7049
<211> 1314
<212> PRT
<213> Homo sapiens

<400> 7049
Met Gly Asp Tyr Glu Ile Ser Val Glu Asn Ala Leu Arg Lys Tyr Ile
 1               5                  10                  15      
Leu Val Thr Pro Arg Val Leu Arg Val Gly Ser Pro Glu Ser Ile His
            20                  25                  30          
Ile Gln Ala His Ser Asp Ser Arg Gln Pro Leu Thr Arg Thr Leu Lys
        35                  40                  45              
Val Asn Leu Thr Val Trp Asp Phe Pro Met Arg Lys Thr Val Leu Ala
    50                  55                  60                  
Arg Ser Gln Leu Ile Leu Ser Pro Gly Asn Asn Phe Met Asp Gln Ala
65                  70                  75                  80  
Pro Val Thr Val Pro Glu Ser Leu Met Tyr Leu Pro Lys Pro Gly Gln
                85                  90                  95      
Gln Tyr Val Ile Ile Arg Ala Thr Trp Ala Pro Thr Ser Gly Ser Ser
            100                 105                 110         
Phe Met Glu Lys Met Val Leu Val Ala Leu His Ala Gly Tyr Ile Phe
        115                 120                 125             
Ile Gln Thr Glu Lys Thr Ile Tyr Thr Pro Glu Tyr Leu Val His Tyr
    130                 135                 140                 
Arg Val Phe Thr Val Asn His Lys Met Asp Pro Val Thr Arg Thr Phe
145                 150                 155                 160 
Thr Leu Asp Ile Lys Val Val Phe Pro Asp Glu Gly Trp Gly Val Val
                165                 170                 175     
Val Asp Pro Gly His Trp Gly Tyr Met Asn Pro Lys Gly Ile Thr Val
            180                 185                 190         
Ile Ser Gln Ser Leu Met Ala Lys Asp Gly Phe Phe Phe Ser Ser Phe
        195                 200                 205             
His Leu Pro Glu Leu Val Ser Leu Gly Thr Trp Thr Ile Glu Ala Ser
    210                 215                 220                 
Tyr Gln Ser Thr Pro Lys Gln Lys Phe Glu Ala Ala Phe Asp Val Lys
225                 230                 235                 240 
Glu Tyr Gly Glu Lys Glu Gln Ile Ser Glu Gly Leu Gly His Val Ser
                245                 250                 255     
Leu Gln Lys Asp Thr Leu Met Ala Ala Phe Gln Gly Pro Gly Glu Asp
            260                 265                 270         
Phe Ile Gly Gly Ser Ile Phe Val Asn Val Thr Met Phe Ser Ser Gly
        275                 280                 285             
Gly Glu Met Val Gln Ala Glu Thr Ser Gly Val Lys Ile Ile Gln Ser
    290                 295                 300                 
Pro Tyr Asn Ile Lys Phe Thr Arg Thr Pro Gln Tyr Phe Lys Pro Gly
305                 310                 315                 320 
Met Pro Phe His Phe Arg Val Phe Ile Ser Asn Pro Asp Gly Ser Pro
                325                 330                 335     
Ala Ser Arg Val Leu Val His Ser Gln Asp Gln Lys Val Tyr Thr Ser
            340                 345                 350         
Ala Glu Gly Leu Ala Thr Leu Thr Ile Asn Thr Asp Ala Asn Leu Asp
        355                 360                 365             
Lys Leu Pro Ile Glu Val Lys Thr Glu Glu Ser Leu Gln Pro Glu Glu
    370                 375                 380                 
Gln Ala Ser Ala Lys Met Thr Ala Trp Pro Tyr Leu Thr Gln Asp Gly
385                 390                 395                 400 
Ser Gly Asn Phe Leu His Ile Glu Val Lys Thr Leu Gly Thr Glu Val
                405                 410                 415     
Gly Ser Ser Ile Gln Leu Ser Leu Asn Thr Arg His Gln Asp Pro Lys
            420                 425                 430         
Thr Lys Asp Lys Ile Thr His Phe Thr Ile Leu Val Leu Ser Lys Gly
        435                 440                 445             
Gln Thr Val Ser Ala Lys His Gln Ser Lys Ser Gln Gly Ser Val Tyr
    450                 455                 460                 
Thr Ser Ala Ile Ile Asp Val Thr Ser Ala Met Leu Pro Ser Phe Arg
465                 470                 475                 480 
Ile Leu Ala Phe Tyr Leu Leu Pro Arg Gly Ala Ser Gln Asp Pro Glu
                485                 490                 495     
Leu Val Ala Asp Ser Ile Trp Ile Asp Val Asn Asp Arg Cys Ile Gly
            500                 505                 510         
Met Leu Lys Val Gly Leu Lys Asn Asp Arg Phe Phe Gln Ser Leu Glu
        515                 520                 525             
Pro Asn Ser Gln Val Glu Leu Lys Val Thr Gly Asp Ala Glu Ala Thr
    530                 535                 540                 
Val Gly Leu Val Ala Val Asp Lys Ala Val Tyr Val Leu Asn Ser Lys
545                 550                 555                 560 
His Lys Leu Thr Gln Lys Lys Val Trp Asn Val Val Glu Glu His Asp
                565                 570                 575     
Ile Gly Cys Thr Gly Gly Ser Gly Lys Asp Arg Phe Ala Val Phe Lys
            580                 585                 590         
Asp Ala Gly Leu Asp Leu Lys Ile Ser Thr Gly Met Asp Ser Leu Ala
        595                 600                 605             
Ser Ser Gly Thr Gly Phe Gly Val Asn Lys Phe Lys Thr Glu Leu Glu
    610                 615                 620                 
Gln Lys Cys Cys Glu Ala Gly Leu Arg Glu Ser Pro Val Gly Leu Ser
625                 630                 635                 640 
Cys Glu Glu Arg Thr Trp His Val Arg His Gly Pro Ala Cys Val Ala
                645                 650                 655     
Ala Phe Leu Asp Cys Cys His Leu Ser Glu Thr Leu Thr Arg Glu Ala
            660                 665                 670         
Arg Glu Asp Gln Leu His Leu Trp Thr Thr Asp Glu Glu Glu Asp Phe
        675                 680                 685             
Asp Asp Leu Phe Leu Asp Asp Met Pro Val Arg Thr Leu Phe Pro Glu
    690                 695                 700                 
Ser Trp Leu Trp Arg Lys Phe Thr Leu Pro Lys Ser Lys Ser Gly Ile
705                 710                 715                 720 
Ser His Tyr Pro Ile Ser Val Lys Val Pro Asp Ser Ile Thr Thr Trp
                725                 730                 735     
Gln Phe Val Val Val Ser Leu Lys Ala Gly Gln Gly Leu Cys Val Ser
            740                 745                 750         
Asp Pro Phe Glu Leu Thr Val Met Lys Ser Phe Phe Val Asp Leu Lys
        755                 760                 765             
Leu Pro Ser Ser Val Ile Arg Asn Glu Gln Val Gln Ile Gln Ala Met
    770                 775                 780                 
Leu Tyr Asn Phe Arg Asp Arg Gln Ala Lys Val Arg Val Glu Phe Pro
785                 790                 795                 800 
His Lys Glu Thr Leu Cys Ser Ala Ser Lys Pro Gly Ala Pro Ser His
                805                 810                 815     
Gln Val Val Val Val Pro Pro Thr Ser Ser Lys Ile Val His Phe Val
            820                 825                 830         
Leu Leu Pro Leu Glu Thr Gly Lys Val Asp Val Glu Val Lys Ala Val
        835                 840                 845             
Gly Tyr Gly Val Gln Asp His Val Lys Lys Thr Leu Leu Val Arg Ala
    850                 855                 860                 
Gly Val Gln Ile Gln Gln Thr Ser Tyr Ser Ile Val Leu Glu Pro Gln
865                 870                 875                 880 
Gly Asp Ile Leu Gly Glu Thr Ile Val Gly Ser Leu Thr Pro Ser Glu
                885                 890                 895     
Ile Gln Gln Leu Leu Arg Val Pro Thr Gly Cys Pro Glu Gln Thr Leu
            900                 905                 910         
Ser Ser Leu Thr Pro Val Ile Ile Leu Ser Arg Tyr Leu Asp Thr Thr
        915                 920                 925             
Gly Gln Trp Gly Lys Val Gly Val Glu His Arg Asp Gln Val Met Lys
    930                 935                 940                 
Asn Ile Val Ser Val Pro Ala Arg Gln Val Ile Pro Asp Asn Thr Asp
945                 950                 955                 960 
Cys Pro Ser Lys Pro Cys Ser Val Ser Pro Gly Tyr Thr Gln Met Leu
                965                 970                 975     
Thr His Arg Ser Ser Asp Gly Thr Tyr His Thr Ser Lys Gly Asn Pro
            980                 985                 990         
Gly Ser Thr Trp Leu Thr Ser Tyr Val Phe Arg Val Phe Ala Leu Ala
        995                 1000                1005            
Tyr Ser Met Met Thr Thr Gln Val Leu Ser Leu Ser Ser Leu Cys Asp
    1010                1015                1020                
Met Ala Asn Trp Ile Ile Ile Asp Arg Gln Ala Glu Asp Gly His Phe
1025                1030                1035                1040
Leu Glu Lys Gly Pro Val Val Met Thr Ser Met Gln Asp Gly Tyr Gln
                1045                1050                1055    
Gly Ser Glu Glu Asp Val Ser Leu Thr Ala Leu Val Leu Ile Ala Leu
            1060                1065                1070        
Asn Glu Gly Lys Glu Leu Cys Arg Gln Lys Asn Leu Met Ala Ser Ile
        1075                1080                1085            
Glu Arg Ala Arg Gly Phe Leu Glu Arg Lys Leu Pro Asp Ile Gln Thr
    1090                1095                1100                
Thr Phe Ala Val Ala Ile Ala Ser Tyr Ala Leu Ala Leu Ala Asn Ser
1105                1110                1115                1120
Ser Gln Ala Asn Asp Cys Leu Asp Ser Phe Ala Ser Pro Asn Lys Thr
                1125                1130                1135    
His Trp Pro Val Asp Glu Gln Asn Leu Gly Ser Leu Tyr Thr Ile Glu
            1140                1145                1150        
Ala Thr Ala Tyr Gly Leu Met Gln Lys Leu Glu Leu Gly Arg Tyr Asn
        1155                1160                1165            
Glu Thr His Ala Ile Ala Lys Trp Leu Leu Glu Lys Gln Glu Leu Gly
    1170                1175                1180                
Gly Gly Phe Arg Ser Thr Gln Thr Thr Val Val Ala Leu Glu Ala Leu
1185                1190                1195                1200
Thr Arg Phe Arg Glu Ala Val Pro Phe Lys Gly Ile Gln Asp Leu His
                1205                1210                1215    
Val Gln Ile Arg Ala Pro Lys Thr Ala Leu Asn Val Asn Trp Tyr Ile
            1220                1225                1230        
Asp His Ser Asn Ala Tyr Gln Gln Arg Ser Ala Lys Phe Leu Ala Gln
        1235                1240                1245            
Asp Asp Leu Glu Ile Lys Ala Ser Gly Asn Gly Arg Gly Thr Ile Ser
    1250                1255                1260                
Ile Leu Thr Met Tyr His Lys Ser Pro Glu Ser Arg Glu Asp Asn Cys
1265                1270                1275                1280
Asn Leu Tyr His Leu Asn Ala Thr Leu His Ser Ala Leu Glu Glu Asn
                1285                1290                1295    
Lys Lys Gly Gly Glu Thr Phe Arg Leu Arg Met Glu Thr Arg Leu Tyr
            1300                1305                1310        
Leu Ser
        


<210> 7050
<211> 795
<212> PRT
<213> Homo sapiens

<400> 7050
Met Leu Ser Gln Val Tyr Arg Cys Gly Phe Gln Pro Phe Asn Gln His
 1               5                  10                  15      
Leu Leu Pro Trp Val Lys Cys Thr Thr Val Phe Arg Ser His Cys Ile
            20                  25                  30          
Gln Pro Ser Val Ile Arg His Val Arg Ser Trp Ser Asn Ile Pro Phe
        35                  40                  45              
Ile Thr Val Pro Leu Ser Arg Thr His Gly Lys Ser Phe Ala His Arg
    50                  55                  60                  
Ser Glu Leu Lys His Ala Lys Arg Ile Val Val Lys Leu Gly Ser Ala
65                  70                  75                  80  
Val Val Thr Arg Gly Asp Glu Cys Gly Leu Ala Leu Gly Arg Leu Ala
                85                  90                  95      
Ser Ile Val Glu Gln Val Ser Val Leu Gln Asn Gln Gly Arg Glu Met
            100                 105                 110         
Met Leu Val Thr Ser Gly Ala Val Ala Phe Gly Lys Gln Arg Leu Arg
        115                 120                 125             
His Glu Ile Leu Leu Ser Gln Ser Val Arg Gln Ala Leu His Ser Gly
    130                 135                 140                 
Gln Asn Gln Leu Lys Glu Met Ala Ile Pro Val Leu Glu Ala Arg Ala
145                 150                 155                 160 
Cys Ala Ala Ala Gly Gln Ser Gly Leu Met Ala Leu Tyr Glu Ala Met
                165                 170                 175     
Phe Thr Gln Tyr Ser Ile Cys Ala Ala Gln Ile Leu Val Thr Asn Leu
            180                 185                 190         
Asp Phe His Asp Glu Gln Lys Arg Arg Asn Leu Asn Gly Thr Leu His
        195                 200                 205             
Glu Leu Leu Arg Met Asn Ile Val Pro Ile Val Asn Thr Asn Asp Ala
    210                 215                 220                 
Val Val Pro Pro Ala Glu Pro Asn Ser Asp Leu Gln Gly Val Asn Val
225                 230                 235                 240 
Ile Ser Val Lys Asp Asn Asp Ser Leu Ala Ala Arg Leu Ala Val Glu
                245                 250                 255     
Met Lys Thr Asp Leu Leu Ile Val Leu Ser Asp Val Glu Gly Leu Phe
            260                 265                 270         
Asp Ser Pro Pro Gly Ser Asp Asp Ala Lys Leu Ile Asp Ile Phe Tyr
        275                 280                 285             
Pro Gly Asp Gln Gln Ser Val Thr Phe Gly Thr Lys Ser Arg Val Gly
    290                 295                 300                 
Met Gly Gly Met Glu Ala Lys Val Lys Ala Ala Leu Trp Ala Leu Gln
305                 310                 315                 320 
Gly Gly Thr Ser Val Val Ile Ala Asn Gly Thr His Pro Lys Val Ser
                325                 330                 335     
Gly His Val Ile Thr Asp Ile Val Glu Gly Lys Lys Val Gly Thr Phe
            340                 345                 350         
Phe Ser Glu Val Lys Pro Ala Gly Pro Thr Val Glu Gln Gln Gly Glu
        355                 360                 365             
Met Ala Arg Ser Gly Gly Arg Met Leu Ala Thr Leu Glu Pro Glu Gln
    370                 375                 380                 
Arg Ala Glu Ile Ile His His Leu Ala Asp Leu Leu Thr Asp Gln Arg
385                 390                 395                 400 
Asp Glu Ile Leu Leu Ala Asn Lys Lys Asp Leu Glu Glu Ala Glu Gly
                405                 410                 415     
Arg Leu Ala Ala Pro Leu Leu Lys Arg Leu Ser Leu Ser Thr Ser Lys
            420                 425                 430         
Leu Asn Ser Leu Ala Ile Gly Leu Arg Gln Ile Ala Ala Ser Ser Gln
        435                 440                 445             
Asp Ser Val Gly Arg Val Leu Arg Arg Thr Arg Ile Ala Lys Asn Leu
    450                 455                 460                 
Glu Leu Glu Gln Val Thr Val Pro Ile Gly Val Leu Leu Val Ile Phe
465                 470                 475                 480 
Glu Ser Arg Pro Asp Cys Leu Pro Gln Val Ala Ala Leu Ala Ile Ala
                485                 490                 495     
Ser Gly Asn Gly Leu Leu Leu Lys Gly Gly Lys Glu Ala Ala His Ser
            500                 505                 510         
Asn Arg Ile Leu His Leu Leu Thr Gln Glu Ala Leu Ser Ile His Gly
        515                 520                 525             
Val Lys Glu Ala Val Gln Leu Val Asn Thr Arg Glu Glu Val Glu Asp
    530                 535                 540                 
Leu Cys Arg Leu Asp Lys Met Ile Asp Leu Ile Ile Pro Arg Gly Ser
545                 550                 555                 560 
Ser Gln Leu Val Arg Asp Ile Gln Lys Ala Ala Lys Gly Ile Pro Val
                565                 570                 575     
Met Gly His Ser Glu Gly Ile Cys His Met Tyr Val Asp Ser Glu Ala
            580                 585                 590         
Ser Val Asp Lys Val Thr Arg Leu Val Arg Asp Ser Lys Cys Glu Tyr
        595                 600                 605             
Pro Ala Ala Cys Asn Ala Leu Glu Thr Leu Leu Ile His Arg Asp Leu
    610                 615                 620                 
Leu Arg Thr Pro Leu Phe Asp Gln Ile Ile Asp Met Leu Arg Val Glu
625                 630                 635                 640 
Gln Val Lys Ile His Ala Gly Pro Lys Phe Ala Ser Tyr Leu Thr Phe
                645                 650                 655     
Ser Pro Ser Glu Val Lys Ser Leu Arg Thr Glu Tyr Gly Asp Leu Glu
            660                 665                 670         
Leu Cys Ile Glu Val Val Asp Asn Val Gln Asp Ala Ile Asp His Ile
        675                 680                 685             
His Lys Tyr Gly Ser Ser His Thr Asp Val Ile Val Thr Glu Asp Glu
    690                 695                 700                 
Asn Thr Ala Glu Phe Phe Leu Gln His Val Asp Ser Ala Cys Val Phe
705                 710                 715                 720 
Trp Asn Ala Ser Thr Arg Phe Ser Asp Gly Tyr Arg Phe Gly Leu Gly
                725                 730                 735     
Ala Glu Val Gly Ile Ser Thr Ser Arg Ile His Ala Arg Gly Pro Val
            740                 745                 750         
Gly Leu Glu Gly Leu Leu Thr Thr Lys Trp Leu Leu Arg Gly Lys Asp
        755                 760                 765             
His Val Val Ser Asp Phe Ser Glu His Gly Ser Leu Lys Tyr Leu His
    770                 775                 780                 
Glu Asn Leu Pro Ile Pro Gln Arg Asn Thr Asn
785                 790                 795 


<210> 7051
<211> 793
<212> PRT
<213> Homo sapiens

<400> 7051
Met Leu Ser Gln Val Tyr Arg Cys Gly Phe Gln Pro Phe Asn Gln His
 1               5                  10                  15      
Leu Leu Pro Trp Val Lys Cys Thr Thr Val Phe Arg Ser His Cys Ile
            20                  25                  30          
Gln Pro Ser Val Ile Arg His Val Arg Ser Trp Ser Asn Ile Pro Phe
        35                  40                  45              
Ile Thr Val Pro Leu Ser Arg Thr His Gly Lys Ser Phe Ala His Arg
    50                  55                  60                  
Ser Glu Leu Lys His Ala Lys Arg Ile Val Val Lys Leu Gly Ser Ala
65                  70                  75                  80  
Val Val Thr Arg Gly Asp Glu Cys Gly Leu Ala Leu Gly Arg Leu Ala
                85                  90                  95      
Ser Ile Val Glu Gln Val Ser Val Leu Gln Asn Gln Gly Arg Glu Met
            100                 105                 110         
Met Leu Val Thr Ser Gly Ala Val Ala Phe Gly Lys Gln Arg Leu Arg
        115                 120                 125             
His Glu Ile Leu Leu Ser Gln Ser Val Arg Gln Ala Leu His Ser Gly
    130                 135                 140                 
Gln Asn Gln Leu Lys Glu Met Ala Ile Pro Val Leu Glu Ala Arg Ala
145                 150                 155                 160 
Cys Ala Ala Ala Gly Gln Ser Gly Leu Met Ala Leu Tyr Glu Ala Met
                165                 170                 175     
Phe Thr Gln Tyr Ser Ile Cys Ala Ala Gln Ile Leu Val Thr Asn Leu
            180                 185                 190         
Asp Phe His Asp Glu Gln Lys Arg Arg Asn Leu Asn Gly Thr Leu His
        195                 200                 205             
Glu Leu Leu Arg Met Asn Ile Val Pro Ile Val Asn Thr Asn Asp Ala
    210                 215                 220                 
Val Val Pro Pro Ala Glu Pro Asn Ser Asp Leu Gln Gly Val Ile Ser
225                 230                 235                 240 
Val Lys Asp Asn Asp Ser Leu Ala Ala Arg Leu Ala Val Glu Met Lys
                245                 250                 255     
Thr Asp Leu Leu Ile Val Leu Ser Asp Val Glu Gly Leu Phe Asp Ser
            260                 265                 270         
Pro Pro Gly Ser Asp Asp Ala Lys Leu Ile Asp Ile Phe Tyr Pro Gly
        275                 280                 285             
Asp Gln Gln Ser Val Thr Phe Gly Thr Lys Ser Arg Val Gly Met Gly
    290                 295                 300                 
Gly Met Glu Ala Lys Val Lys Ala Ala Leu Trp Ala Leu Gln Gly Gly
305                 310                 315                 320 
Thr Ser Val Val Ile Ala Asn Gly Thr His Pro Lys Val Ser Gly His
                325                 330                 335     
Val Ile Thr Asp Ile Val Glu Gly Lys Lys Val Gly Thr Phe Phe Ser
            340                 345                 350         
Glu Val Lys Pro Ala Gly Pro Thr Val Glu Gln Gln Gly Glu Met Ala
        355                 360                 365             
Arg Ser Gly Gly Arg Met Leu Ala Thr Leu Glu Pro Glu Gln Arg Ala
    370                 375                 380                 
Glu Ile Ile His His Leu Ala Asp Leu Leu Thr Asp Gln Arg Asp Glu
385                 390                 395                 400 
Ile Leu Leu Ala Asn Lys Lys Asp Leu Glu Glu Ala Glu Gly Arg Leu
                405                 410                 415     
Ala Ala Pro Leu Leu Lys Arg Leu Ser Leu Ser Thr Ser Lys Leu Asn
            420                 425                 430         
Ser Leu Ala Ile Gly Leu Arg Gln Ile Ala Ala Ser Ser Gln Asp Ser
        435                 440                 445             
Val Gly Arg Val Leu Arg Arg Thr Arg Ile Ala Lys Asn Leu Glu Leu
    450                 455                 460                 
Glu Gln Val Thr Val Pro Ile Gly Val Leu Leu Val Ile Phe Glu Ser
465                 470                 475                 480 
Arg Pro Asp Cys Leu Pro Gln Val Ala Ala Leu Ala Ile Ala Ser Gly
                485                 490                 495     
Asn Gly Leu Leu Leu Lys Gly Gly Lys Glu Ala Ala His Ser Asn Arg
            500                 505                 510         
Ile Leu His Leu Leu Thr Gln Glu Ala Leu Ser Ile His Gly Val Lys
        515                 520                 525             
Glu Ala Val Gln Leu Val Asn Thr Arg Glu Glu Val Glu Asp Leu Cys
    530                 535                 540                 
Arg Leu Asp Lys Met Ile Asp Leu Ile Ile Pro Arg Gly Ser Ser Gln
545                 550                 555                 560 
Leu Val Arg Asp Ile Gln Lys Ala Ala Lys Gly Ile Pro Val Met Gly
                565                 570                 575     
His Ser Glu Gly Ile Cys His Met Tyr Val Asp Ser Glu Ala Ser Val
            580                 585                 590         
Asp Lys Val Thr Arg Leu Val Arg Asp Ser Lys Cys Glu Tyr Pro Ala
        595                 600                 605             
Ala Cys Asn Ala Leu Glu Thr Leu Leu Ile His Arg Asp Leu Leu Arg
    610                 615                 620                 
Thr Pro Leu Phe Asp Gln Ile Ile Asp Met Leu Arg Val Glu Gln Val
625                 630                 635                 640 
Lys Ile His Ala Gly Pro Lys Phe Ala Ser Tyr Leu Thr Phe Ser Pro
                645                 650                 655     
Ser Glu Val Lys Ser Leu Arg Thr Glu Tyr Gly Asp Leu Glu Leu Cys
            660                 665                 670         
Ile Glu Val Val Asp Asn Val Gln Asp Ala Ile Asp His Ile His Lys
        675                 680                 685             
Tyr Gly Ser Ser His Thr Asp Val Ile Val Thr Glu Asp Glu Asn Thr
    690                 695                 700                 
Ala Glu Phe Phe Leu Gln His Val Asp Ser Ala Cys Val Phe Trp Asn
705                 710                 715                 720 
Ala Ser Thr Arg Phe Ser Asp Gly Tyr Arg Phe Gly Leu Gly Ala Glu
                725                 730                 735     
Val Gly Ile Ser Thr Ser Arg Ile His Ala Arg Gly Pro Val Gly Leu
            740                 745                 750         
Glu Gly Leu Leu Thr Thr Lys Trp Leu Leu Arg Gly Lys Asp His Val
        755                 760                 765             
Val Ser Asp Phe Ser Glu His Gly Ser Leu Lys Tyr Leu His Glu Asn
    770                 775                 780                 
Leu Pro Ile Pro Gln Arg Asn Thr Asn
785                 790             


<210> 7052
<211> 365
<212> PRT
<213> Homo sapiens

<400> 7052
Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg
 1               5                  10                  15      
Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser
            20                  25                  30          
Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn
        35                  40                  45              
Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr
    50                  55                  60                  
Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe
65                  70                  75                  80  
Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn
                85                  90                  95      
Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys
            100                 105                 110         
Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser
        115                 120                 125             
Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro
    130                 135                 140                 
Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln
145                 150                 155                 160 
Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe
                165                 170                 175     
Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg
            180                 185                 190         
Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu
        195                 200                 205             
Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val
    210                 215                 220                 
Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His
225                 230                 235                 240 
Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys
                245                 250                 255     
Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg
            260                 265                 270         
Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro
        275                 280                 285             
Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser
    290                 295                 300                 
Lys Ser Pro Ala Asp Ser Gly Asn Asp Gln Asp Ala Asn Gly Thr Ser
305                 310                 315                 320 
Ser Ser Gln Leu Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr
                325                 330                 335     
Pro Thr Ser Pro Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro
            340                 345                 350         
Leu Ser Leu Asp Asp Ser Asp Ser Leu Gly Asp Ser Met
        355                 360                 365 


<210> 7053
<211> 361
<212> PRT
<213> Homo sapiens

<400> 7053
Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg
 1               5                  10                  15      
Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser
            20                  25                  30          
Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn
        35                  40                  45              
Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr
    50                  55                  60                  
Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe
65                  70                  75                  80  
Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn
                85                  90                  95      
Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys
            100                 105                 110         
Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser
        115                 120                 125             
Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro
    130                 135                 140                 
Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln
145                 150                 155                 160 
Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe
                165                 170                 175     
Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg
            180                 185                 190         
Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu
        195                 200                 205             
Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val
    210                 215                 220                 
Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His
225                 230                 235                 240 
Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys
                245                 250                 255     
Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg
            260                 265                 270         
Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro
        275                 280                 285             
Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser
    290                 295                 300                 
Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu Ser
305                 310                 315                 320 
Thr Pro Lys Ser Val Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro
                325                 330                 335     
Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp
            340                 345                 350         
Asp Ser Asp Ser Leu Gly Asp Ser Met
        355                 360     


<210> 7054
<211> 729
<212> PRT
<213> Homo sapiens

<400> 7054
Met Ser Phe Gly Arg Asp Met Glu Leu Glu His Phe Asp Glu Arg Asp
 1               5                  10                  15      
Lys Ala Gln Arg Tyr Ser Arg Gly Ser Arg Val Asn Gly Leu Pro Ser
            20                  25                  30          
Pro Thr His Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln
        35                  40                  45              
Thr Leu Ser Ser Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn
    50                  55                  60                  
Gly Asp Arg Tyr Phe Lys Gly Ile Val Tyr Ala Ile Ser Pro Asp Arg
65                  70                  75                  80  
Phe Arg Ser Phe Glu Ala Leu Leu Ala Asp Leu Thr Arg Thr Leu Ser
                85                  90                  95      
Asp Asn Val Asn Leu Pro Gln Gly Val Arg Thr Ile Tyr Thr Ile Asp
            100                 105                 110         
Gly Leu Lys Lys Ile Ser Ser Leu Asp Gln Leu Val Glu Gly Glu Ser
        115                 120                 125             
Tyr Val Cys Gly Ser Ile Glu Pro Phe Lys Lys Leu Glu Tyr Thr Lys
    130                 135                 140                 
Asn Val Asn Pro Asn Trp Ser Val Asn Val Lys Thr Thr Ser Ala Ser
145                 150                 155                 160 
Arg Ala Val Ser Ser Leu Ala Thr Ala Lys Gly Ser Pro Ser Glu Val
                165                 170                 175     
Arg Glu Asn Lys Asp Phe Ile Arg Pro Lys Leu Val Thr Ile Ile Arg
            180                 185                 190         
Ser Gly Val Lys Pro Arg Lys Ala Val Arg Ile Leu Leu Asn Lys Lys
        195                 200                 205             
Thr Ala His Ser Phe Glu Gln Val Leu Thr Asp Ile Thr Asp Ala Ile
    210                 215                 220                 
Lys Leu Asp Ser Gly Val Val Lys Arg Leu Tyr Thr Leu Asp Gly Lys
225                 230                 235                 240 
Gln Val Met Cys Leu Gln Asp Phe Phe Gly Asp Asp Asp Ile Phe Ile
                245                 250                 255     
Ala Cys Gly Pro Glu Lys Phe Arg Tyr Gln Asp Asp Phe Leu Leu Asp
            260                 265                 270         
Glu Ser Glu Cys Arg Val Val Lys Ser Thr Ser Tyr Thr Lys Ile Ala
        275                 280                 285             
Ser Ser Ser Arg Arg Ser Thr Thr Lys Ser Pro Gly Pro Ser Arg Arg
    290                 295                 300                 
Ser Lys Ser Pro Ala Ser Thr Ser Ser Val Asn Gly Thr Pro Gly Ser
305                 310                 315                 320 
Gln Leu Ser Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr
                325                 330                 335     
Ser Pro Gly Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser
            340                 345                 350         
Ser Thr Ser Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn
        355                 360                 365             
Asp Gly Pro Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala
    370                 375                 380                 
Thr Ile Thr Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn
385                 390                 395                 400 
Phe Ala Val Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr
                405                 410                 415     
Ala Leu Lys Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met
            420                 425                 430         
Ile Gln Asn Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile
        435                 440                 445             
Val Leu Leu Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val
    450                 455                 460                 
Met Glu Leu Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr
465                 470                 475                 480 
Asn Lys Tyr Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala
                485                 490                 495     
Ser Ala Ile Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile
            500                 505                 510         
Lys Pro Glu Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser
        515                 520                 525             
Leu Lys Leu Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu
    530                 535                 540                 
Tyr Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala
545                 550                 555                 560 
Glu Thr Gly Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile
                565                 570                 575     
Thr Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp
            580                 585                 590         
Asp Gln Glu Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe
        595                 600                 605             
Pro Ser Pro Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile
    610                 615                 620                 
Thr Met Met Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln
625                 630                 635                 640 
Val Leu Glu His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu
                645                 650                 655     
His Gln Leu Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly
            660                 665                 670         
Pro Lys Pro Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Leu Asp
        675                 680                 685             
His Gly Phe Thr Ile Lys Arg Ser Gly Ser Leu Asp Tyr Tyr Gln Gln
    690                 695                 700                 
Pro Gly Met Tyr Trp Ile Arg Pro Pro Leu Leu Ile Arg Arg Gly Arg
705                 710                 715                 720 
Phe Ser Asp Glu Asp Ala Thr Arg Met
                725                 


<210> 7055
<211> 740
<212> PRT
<213> Homo sapiens

<400> 7055
Met Ser Phe Gly Arg Asp Met Glu Leu Glu His Phe Asp Glu Arg Asp
 1               5                  10                  15      
Lys Ala Gln Arg Tyr Ser Arg Gly Ser Arg Val Asn Gly Leu Pro Ser
            20                  25                  30          
Pro Thr His Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln
        35                  40                  45              
Thr Leu Ser Ser Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn
    50                  55                  60                  
Gly Asp Arg Tyr Phe Lys Gly Ile Val Tyr Ala Ile Ser Pro Asp Arg
65                  70                  75                  80  
Phe Arg Ser Phe Glu Ala Leu Leu Ala Asp Leu Thr Arg Thr Leu Ser
                85                  90                  95      
Asp Asn Val Asn Leu Pro Gln Gly Val Arg Thr Ile Tyr Thr Ile Asp
            100                 105                 110         
Gly Leu Lys Lys Ile Ser Ser Leu Asp Gln Leu Val Glu Gly Glu Ser
        115                 120                 125             
Tyr Val Cys Gly Ser Ile Glu Pro Phe Lys Lys Leu Glu Tyr Thr Lys
    130                 135                 140                 
Asn Val Asn Pro Asn Trp Ser Val Asn Val Lys Thr Thr Ser Ala Ser
145                 150                 155                 160 
Arg Ala Val Ser Ser Leu Ala Thr Ala Lys Gly Ser Pro Ser Glu Val
                165                 170                 175     
Arg Glu Asn Lys Asp Phe Ile Arg Pro Lys Leu Val Thr Ile Ile Arg
            180                 185                 190         
Ser Gly Val Lys Pro Arg Lys Ala Val Arg Ile Leu Leu Asn Lys Lys
        195                 200                 205             
Thr Ala His Ser Phe Glu Gln Val Leu Thr Asp Ile Thr Asp Ala Ile
    210                 215                 220                 
Lys Leu Asp Ser Gly Val Val Lys Arg Leu Tyr Thr Leu Asp Gly Lys
225                 230                 235                 240 
Gln Val Met Cys Leu Gln Asp Phe Phe Gly Asp Asp Asp Ile Phe Ile
                245                 250                 255     
Ala Cys Gly Pro Glu Lys Phe Arg Tyr Gln Asp Asp Phe Leu Leu Asp
            260                 265                 270         
Glu Ser Glu Cys Arg Val Val Lys Ser Thr Ser Tyr Thr Lys Ile Ala
        275                 280                 285             
Ser Ser Ser Arg Arg Ser Thr Thr Lys Ser Pro Gly Pro Ser Arg Arg
    290                 295                 300                 
Ser Lys Ser Pro Ala Ser Thr Ser Ser Val Asn Gly Thr Pro Gly Ser
305                 310                 315                 320 
Gln Leu Ser Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr
                325                 330                 335     
Ser Pro Gly Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser
            340                 345                 350         
Ser Thr Ser Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn
        355                 360                 365             
Asp Gly Pro Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala
    370                 375                 380                 
Thr Ile Thr Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn
385                 390                 395                 400 
Phe Ala Val Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr
                405                 410                 415     
Ala Leu Lys Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met
            420                 425                 430         
Ile Gln Asn Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile
        435                 440                 445             
Val Leu Leu Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val
    450                 455                 460                 
Met Glu Leu Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr
465                 470                 475                 480 
Asn Lys Tyr Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala
                485                 490                 495     
Ser Ala Ile Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile
            500                 505                 510         
Lys Pro Glu Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser
        515                 520                 525             
Leu Lys Leu Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu
    530                 535                 540                 
Tyr Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala
545                 550                 555                 560 
Glu Thr Gly Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile
                565                 570                 575     
Thr Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp
            580                 585                 590         
Asp Gln Glu Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe
        595                 600                 605             
Pro Ser Pro Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile
    610                 615                 620                 
Thr Met Met Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln
625                 630                 635                 640 
Val Leu Glu His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu
                645                 650                 655     
His Gln Leu Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly
            660                 665                 670         
Pro Lys Pro Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Thr Thr
        675                 680                 685             
Ala Leu Asp Lys Glu Arg Gln Val Phe Arg Arg Arg Arg Asn Gln Asp
    690                 695                 700                 
Val Arg Ser Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser
705                 710                 715                 720 
Glu Ser Glu Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro
                725                 730                 735     
Asn Ser Pro Phe
            740 


<210> 7056
<211> 942
<212> PRT
<213> Homo sapiens

<400> 7056
Met Ala Ala Ala Ala Glu Pro Gly Ala Arg Ala Trp Leu Gly Gly Gly
 1               5                  10                  15      
Ser Pro Arg Pro Gly Ser Pro Ala Cys Ser Pro Val Leu Gly Ser Gly
            20                  25                  30          
Gly Arg Ala Arg Pro Gly Pro Gly Pro Gly Pro Gly Arg Asp Arg Ala
        35                  40                  45              
Gly Gly Val Arg Ala Arg Ala Arg Ala Ala Pro Gly His Ser Phe Arg
    50                  55                  60                  
Lys Val Thr Leu Thr Lys Pro Thr Phe Cys His Leu Cys Ser Asp Phe
65                  70                  75                  80  
Ile Trp Gly Leu Ala Gly Phe Leu Cys Asp Val Cys Asn Phe Met Ser
                85                  90                  95      
His Glu Lys Cys Leu Lys His Val Arg Ile Pro Cys Thr Ser Val Ala
            100                 105                 110         
Pro Ser Leu Val Arg Val Pro Val Ala His Cys Phe Gly Pro Arg Gly
        115                 120                 125             
Leu His Lys Arg Lys Phe Cys Ala Val Cys Arg Lys Val Leu Glu Ala
    130                 135                 140                 
Pro Ala Leu His Cys Glu Val Cys Glu Leu His Leu His Pro Asp Cys
145                 150                 155                 160 
Val Pro Phe Ala Cys Ser Asp Cys Arg Gln Cys His Gln Asp Gly His
                165                 170                 175     
Gln Asp His Asp Thr His His His His Trp Arg Glu Gly Asn Leu Pro
            180                 185                 190         
Ser Gly Ala Arg Cys Glu Val Cys Arg Lys Thr Cys Gly Ser Ser Asp
        195                 200                 205             
Val Leu Ala Gly Val Arg Cys Glu Trp Cys Gly Val Gln Ala His Ser
    210                 215                 220                 
Leu Cys Ser Ala Ala Leu Ala Pro Glu Cys Gly Phe Gly Arg Leu Arg
225                 230                 235                 240 
Ser Leu Val Leu Pro Pro Ala Cys Val Arg Leu Leu Pro Gly Gly Phe
                245                 250                 255     
Ser Lys Thr Gln Ser Phe Arg Ile Val Glu Ala Ala Glu Pro Gly Glu
            260                 265                 270         
Gly Gly Asp Gly Ala Asp Gly Ser Ala Ala Val Gly Pro Gly Arg Glu
        275                 280                 285             
Thr Gln Ala Thr Pro Glu Ser Gly Lys Gln Thr Leu Lys Ile Phe Asp
    290                 295                 300                 
Gly Asp Asp Ala Val Arg Arg Ser Gln Phe Arg Leu Val Thr Val Ser
305                 310                 315                 320 
Arg Leu Ala Gly Ala Glu Glu Val Leu Glu Ala Ala Leu Arg Ala His
                325                 330                 335     
His Ile Pro Glu Asp Pro Gly His Leu Glu Leu Cys Arg Leu Pro Pro
            340                 345                 350         
Ser Ser Gln Ala Cys Asp Ala Trp Ala Gly Gly Lys Ala Gly Ser Ala
        355                 360                 365             
Val Ile Ser Glu Glu Gly Arg Ser Pro Gly Ser Gly Glu Ala Thr Pro
    370                 375                 380                 
Glu Ala Trp Val Ile Arg Ala Leu Pro Arg Ala Gln Glu Val Leu Lys
385                 390                 395                 400 
Ile Tyr Pro Gly Trp Leu Lys Val Gly Val Ala Tyr Val Ser Val Arg
                405                 410                 415     
Val Thr Pro Lys Ser Thr Ala Arg Ser Val Val Leu Glu Val Leu Pro
            420                 425                 430         
Leu Leu Gly Arg Gln Ala Glu Ser Pro Glu Ser Phe Gln Leu Val Glu
        435                 440                 445             
Val Ala Met Gly Cys Arg His Val Gln Arg Thr Met Leu Met Asp Glu
    450                 455                 460                 
Gln Pro Leu Leu Asp Arg Leu Gln Asp Ile Arg Gln Met Ser Val Arg
465                 470                 475                 480 
Gln Val Ser Gln Thr Arg Phe Tyr Val Ala Glu Ser Arg Asp Val Ala
                485                 490                 495     
Pro His Val Ser Leu Phe Val Gly Gly Leu Pro Pro Gly Leu Ser Pro
            500                 505                 510         
Glu Glu Tyr Ser Ser Leu Leu His Glu Ala Gly Ala Thr Lys Ala Thr
        515                 520                 525             
Val Val Ser Val Ser His Ile Tyr Ser Ser Gln Gly Ala Val Val Leu
    530                 535                 540                 
Asp Val Ala Cys Phe Ala Glu Ala Glu Arg Leu Tyr Met Leu Leu Lys
545                 550                 555                 560 
Asp Met Ala Val Arg Gly Arg Leu Leu Thr Ala Leu Val Leu Pro Asp
                565                 570                 575     
Leu Leu His Ala Lys Leu Pro Pro Asp Ser Cys Pro Leu Leu Val Phe
            580                 585                 590         
Val Asn Pro Lys Ser Gly Gly Leu Lys Gly Arg Asp Leu Leu Cys Ser
        595                 600                 605             
Phe Arg Lys Leu Leu Asn Pro His Gln Val Phe Asp Leu Thr Asn Gly
    610                 615                 620                 
Gly Pro Leu Pro Gly Leu His Leu Phe Ser Gln Val Pro Cys Phe Arg
625                 630                 635                 640 
Val Leu Val Cys Gly Gly Asp Gly Thr Val Gly Trp Val Leu Gly Ala
                645                 650                 655     
Leu Glu Glu Thr Arg Tyr Arg Leu Ala Cys Pro Glu Pro Ser Val Ala
            660                 665                 670         
Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Gly Arg Val Leu Arg Trp
        675                 680                 685             
Gly Ala Gly Tyr Ser Gly Glu Asp Pro Phe Ser Val Leu Leu Ser Val
    690                 695                 700                 
Asp Glu Ala Asp Ala Val Leu Met Asp Arg Trp Thr Ile Leu Leu Asp
705                 710                 715                 720 
Ala His Glu Ala Gly Ser Ala Glu Asn Asp Thr Ala Asp Ala Glu Pro
                725                 730                 735     
Pro Lys Ile Val Gln Met Ser Asn Tyr Cys Gly Ile Gly Ile Asp Ala
            740                 745                 750         
Glu Leu Ser Leu Asp Phe His Gln Ala Arg Glu Glu Glu Pro Gly Lys
        755                 760                 765             
Phe Thr Ser Arg Leu His Asn Lys Gly Val Tyr Val Arg Val Gly Leu
    770                 775                 780                 
Gln Lys Ile Ser His Ser Arg Ser Leu His Lys Gln Ile Arg Leu Gln
785                 790                 795                 800 
Val Glu Arg Gln Glu Val Glu Leu Pro Ser Ile Glu Gly Leu Ile Phe
                805                 810                 815     
Ile Asn Ile Pro Ser Trp Gly Ser Gly Ala Asp Leu Trp Gly Ser Asp
            820                 825                 830         
Ser Asp Thr Arg Phe Glu Lys Pro Arg Met Asp Asp Gly Leu Leu Glu
        835                 840                 845             
Val Val Gly Val Thr Gly Val Val His Met Gly Gln Val Gln Gly Gly
    850                 855                 860                 
Leu Arg Ser Gly Ile Arg Ile Ala Gln Gly Ser Tyr Phe Arg Val Thr
865                 870                 875                 880 
Leu Leu Lys Ala Thr Pro Val Gln Val Asp Gly Glu Pro Trp Val Gln
                885                 890                 895     
Ala Pro Gly His Met Ile Ile Ser Ala Ala Gly Pro Lys Val His Met
            900                 905                 910         
Leu Arg Lys Ala Lys Gln Lys Pro Arg Arg Ala Gly Thr Thr Arg Asp
        915                 920                 925             
Ala Arg Ala Asp Arg Ala Pro Ala Pro Glu Ser Asp Pro Arg
    930                 935                 940         


<210> 7057
<211> 409
<212> PRT
<213> Homo sapiens

<400> 7057
Met Met Lys Lys Asn Asn Ser Ala Lys Arg Gly Pro Gln Asp Gly Asn
 1               5                  10                  15      
Gln Gln Pro Ala Pro Pro Glu Lys Val Gly Trp Val Arg Lys Phe Cys
            20                  25                  30          
Gly Lys Gly Ile Phe Arg Glu Ile Trp Lys Asn Arg Tyr Val Val Leu
        35                  40                  45              
Lys Gly Asp Gln Leu Tyr Ile Ser Glu Lys Glu Val Lys Asp Glu Lys
    50                  55                  60                  
Asn Ile Gln Glu Val Phe Asp Leu Ser Asp Tyr Glu Lys Cys Glu Glu
65                  70                  75                  80  
Leu Arg Lys Ser Lys Ser Arg Ser Lys Lys Asn His Ser Lys Phe Thr
                85                  90                  95      
Leu Ala His Ser Lys Gln Pro Gly Asn Thr Ala Pro Asn Leu Ile Phe
            100                 105                 110         
Leu Ala Val Ser Pro Glu Glu Lys Glu Ser Trp Ile Asn Ala Leu Asn
        115                 120                 125             
Ser Ala Ile Thr Arg Ala Lys Asn Arg Ile Leu Asp Glu Val Thr Val
    130                 135                 140                 
Glu Glu Asp Ser Tyr Leu Ala His Pro Thr Arg Asp Arg Ala Lys Ile
145                 150                 155                 160 
Gln His Ser Arg Arg Pro Pro Thr Arg Gly His Leu Met Ala Val Ala
                165                 170                 175     
Ser Thr Ser Thr Ser Asp Gly Met Leu Thr Leu Asp Leu Ile Gln Glu
            180                 185                 190         
Glu Asp Pro Ser Pro Glu Glu Pro Thr Ser Cys Ala Glu Ser Phe Arg
        195                 200                 205             
Val Asp Leu Asp Lys Ser Val Ala Gln Leu Ala Gly Ser Arg Arg Arg
    210                 215                 220                 
Ala Asp Ser Asp Arg Ile Gln Pro Ser Ala Asp Arg Ala Ser Ser Leu
225                 230                 235                 240 
Ser Arg Pro Trp Glu Lys Thr Asp Lys Gly Ala Thr Tyr Thr Pro Gln
                245                 250                 255     
Ala Pro Lys Lys Leu Thr Pro Thr Glu Lys Gly Arg Cys Ala Ser Leu
            260                 265                 270         
Glu Glu Ile Leu Ser Gln Arg Asp Ala Ala Ser Ala Arg Thr Leu Gln
        275                 280                 285             
Leu Arg Ala Glu Glu Pro Pro Thr Pro Ala Leu Pro Asn Pro Gly Gln
    290                 295                 300                 
Leu Ser Arg Ile Gln Asp Leu Val Ala Arg Lys Leu Glu Glu Thr Gln
305                 310                 315                 320 
Glu Leu Leu Ala Glu Val Gln Gly Leu Gly Asp Gly Lys Arg Lys Ala
                325                 330                 335     
Lys Asp Pro Pro Arg Ser Pro Pro Asp Ser Glu Ser Glu Gln Leu Leu
            340                 345                 350         
Leu Glu Thr Glu Arg Leu Leu Gly Glu Ala Ser Ser Asn Trp Ser Gln
        355                 360                 365             
Ala Lys Arg Val Leu Gln Glu Val Arg Glu Leu Arg Asp Leu Tyr Arg
    370                 375                 380                 
Gln Met Asp Leu Gln Thr Pro Asp Ser His Leu Arg Gln Thr Thr Pro
385                 390                 395                 400 
His Ser Gln Tyr Arg Lys Ser Leu Met
                405                 


<210> 7058
<211> 438
<212> PRT
<213> Homo sapiens

<400> 7058
Gly Thr Arg Val Arg Arg Cys Cys Arg Gly Trp Arg Ser Pro Val Phe
 1               5                  10                  15      
Thr Asn Pro His Val Ser Pro Leu Ser Thr Ala Pro Ala His Trp Ala
            20                  25                  30          
Pro Gly Arg Pro Ala Ala Gly Ser Leu Gly Leu Arg Val Ser Pro Glu
        35                  40                  45              
Pro Pro Pro Glu Arg Gly Ser Leu Pro Pro Gly Glu Arg Ser Pro Ala
    50                  55                  60                  
Ala Ser Lys Pro Pro Ser Ser Pro Ser Gly Pro Gln Asp Gly Asn Gln
65                  70                  75                  80  
Gln Pro Ala Pro Pro Glu Lys Val Gly Trp Val Arg Lys Phe Cys Gly
                85                  90                  95      
Lys Gly Ile Phe Arg Glu Ile Trp Lys Asn Arg Tyr Val Val Leu Lys
            100                 105                 110         
Gly Asp Gln Leu Tyr Ile Ser Glu Lys Glu Val Lys Asp Glu Lys Asn
        115                 120                 125             
Ile Gln Glu Val Phe Asp Leu Ser Asp Tyr Glu Lys Cys Glu Glu Leu
    130                 135                 140                 
Arg Lys Ser Lys Ser Arg Ser Lys Lys Asn His Ser Lys Phe Thr Leu
145                 150                 155                 160 
Ala His Ser Lys Gln Pro Gly Asn Thr Ala Pro Asn Leu Ile Phe Leu
                165                 170                 175     
Ala Val Ser Pro Glu Glu Lys Glu Ser Trp Ile Asn Ala Leu Asn Ser
            180                 185                 190         
Ala Ile Thr Arg Ala Lys Asn Arg Ile Leu Asp Glu Ala Ser Thr Ser
        195                 200                 205             
Thr Ser Asp Gly Met Leu Thr Leu Asp Leu Ile Gln Glu Glu Asp Pro
    210                 215                 220                 
Ser Pro Glu Glu Pro Thr Ser Cys Ala Glu Ser Phe Arg Val Asp Leu
225                 230                 235                 240 
Asp Lys Ser Val Ala Gln Leu Ala Gly Ser Arg Arg Arg Ala Asp Ser
                245                 250                 255     
Asp Arg Ile Gln Pro Ser Ala Asp Arg Ala Ser Ser Leu Ser Arg Pro
            260                 265                 270         
Trp Glu Lys Thr Asp Lys Gly Ala Thr Tyr Thr Pro Gln Ala Pro Lys
        275                 280                 285             
Lys Leu Thr Pro Thr Glu Lys Gly Arg Cys Ala Ser Leu Glu Glu Ile
    290                 295                 300                 
Leu Ser Gln Arg Asp Ala Ala Ser Ala Arg Thr Leu Gln Leu Arg Ala
305                 310                 315                 320 
Glu Glu Pro Pro Thr Pro Ala Leu Pro Asn Pro Gly Gln Leu Ser Arg
                325                 330                 335     
Ile Gln Asp Leu Val Ala Arg Lys Leu Glu Glu Thr Gln Glu Leu Leu
            340                 345                 350         
Ala Glu Val Gln Gly Leu Gly Asp Gly Lys Arg Lys Ala Lys Asp Pro
        355                 360                 365             
Pro Arg Ser Pro Pro Asp Ser Glu Ser Glu Gln Leu Leu Leu Glu Thr
    370                 375                 380                 
Glu Arg Leu Leu Gly Glu Ala Ser Ser Asn Trp Ser Gln Ala Lys Arg
385                 390                 395                 400 
Val Leu Gln Glu Val Arg Glu Leu Arg Asp Leu Tyr Arg Gln Met Asp
                405                 410                 415     
Leu Gln Thr Pro Asp Ser His Leu Arg Gln Thr Thr Pro His Ser Gln
            420                 425                 430         
Tyr Arg Lys Ser Leu Met
        435             


<210> 7059
<211> 514
<212> PRT
<213> Homo sapiens

<400> 7059
Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln
 1               5                  10                  15      
Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Thr Ser Thr Ala
            20                  25                  30          
Tyr Thr Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Thr Ala
        35                  40                  45              
Gly Gly Glu Thr Gln Asn Ala Ala Ala Leu Pro Gly Pro Thr Ser Trp
    50                  55                  60                  
Pro Leu Leu Gly Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys
65                  70                  75                  80  
Lys Gln His Asp Thr Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile
                85                  90                  95      
Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro
            100                 105                 110         
Cys Leu Leu Glu Ala Leu Tyr Arg Thr Glu Ser Ala Tyr Pro Gln Arg
        115                 120                 125             
Leu Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly
    130                 135                 140                 
Tyr Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser
145                 150                 155                 160 
Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp
                165                 170                 175     
Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu
            180                 185                 190         
Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn
        195                 200                 205             
Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe
    210                 215                 220                 
Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met
225                 230                 235                 240 
Ala Ile Lys Thr Met Met Ser Thr Phe Gly Arg Met Met Val Thr Pro
                245                 250                 255     
Val Glu Leu His Lys Ser Leu Asn Thr Lys Val Trp Gln Asp His Thr
            260                 265                 270         
Leu Ala Trp Asp Thr Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn
        275                 280                 285             
Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp
    290                 295                 300                 
Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val
305                 310                 315                 320 
Thr Glu Leu Gln Leu Ala Ala Val Glu Thr Thr Ala Asn Ser Leu Met
                325                 330                 335     
Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu
            340                 345                 350         
Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro Arg Ala
        355                 360                 365             
Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser
    370                 375                 380                 
Met Arg Leu Thr Pro Ser Val Pro Phe Thr Thr Arg Thr Leu Asp Lys
385                 390                 395                 400 
Ala Thr Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Thr Val Leu Met
                405                 410                 415     
Leu Asn Thr Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu Asp Ser
            420                 425                 430         
Ser Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys Ile Asn
        435                 440                 445             
Pro Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys Ile Gly
    450                 455                 460                 
Arg Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp Ile Val
465                 470                 475                 480 
Arg Lys Tyr Asp Ile Gln Ala Thr Asp Asn Glu Pro Val Glu Met Leu
                485                 490                 495     
His Ser Gly Thr Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys
            500                 505                 510         
Gln Arg
        


<210> 7060
<211> 707
<212> PRT
<213> Homo sapiens

<400> 7060
Met Gln Thr Ser Glu Thr Gly Ser Asp Thr Gly Ser Thr Val Thr Leu
 1               5                  10                  15      
Gln Thr Ser Val Ala Ser Gln Ala Ala Val Pro Thr Gln Val Val Gln
            20                  25                  30          
Gln Val Pro Val Gln Gln Gln Val Gln Gln Val Gln Thr Val Gln Gln
        35                  40                  45              
Val Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Ser Asp
    50                  55                  60                  
Thr Val Tyr Thr Asn Gly Ala Ile Arg Thr Thr Thr Tyr Pro Tyr Thr
65                  70                  75                  80  
Glu Thr Gln Met Tyr Ser Gln Asn Thr Gly Gly Asn Tyr Phe Asp Thr
                85                  90                  95      
Gln Gly Ser Ser Ala Gln Val Thr Thr Val Val Ser Ser His Ser Met
            100                 105                 110         
Val Gly Thr Gly Gly Ile Gln Met Gly Val Thr Gly Gly Gln Leu Ile
        115                 120                 125             
Ser Ser Ser Gly Gly Thr Tyr Leu Ile Gly Asn Ser Met Glu Asn Ser
    130                 135                 140                 
Gly His Ser Val Thr His Thr Thr Arg Ala Ser Pro Ala Thr Ile Glu
145                 150                 155                 160 
Met Ala Ile Glu Thr Leu Gln Lys Ser Asp Gly Leu Ser Thr His Arg
                165                 170                 175     
Ser Ser Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu
            180                 185                 190         
Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Thr Leu Tyr Asn His Tyr
        195                 200                 205             
Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser
    210                 215                 220                 
Phe Gly Lys Leu Ile Arg Ser Ile Phe Met Gly Leu Arg Thr Arg Arg
225                 230                 235                 240 
Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Val
                245                 250                 255     
Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Met Gln Tyr Met
            260                 265                 270         
Ala Met Arg Gln Gln Pro Met Gln Gln Lys Gln Arg Tyr Lys Pro Met
        275                 280                 285             
Gln Lys Val Asp Gly Val Ala Asp Gly Phe Thr Gly Ser Gly Gln Gln
    290                 295                 300                 
Thr Gly Thr Ser Val Glu Gln Thr Val Ile Ala Gln Ser Gln His His
305                 310                 315                 320 
Gln Gln Phe Leu Asp Ala Ser Arg Ala Leu Pro Glu Phe Gly Glu Val
                325                 330                 335     
Glu Ile Ser Ser Leu Pro Asp Gly Thr Thr Phe Glu Asp Ile Lys Ser
            340                 345                 350         
Leu Gln Ser Leu Tyr Arg Glu His Cys Glu Ala Ile Leu Asp Val Val
        355                 360                 365             
Val Asn Leu Gln Phe Ser Leu Ile Glu Lys Leu Trp Gln Thr Phe Trp
    370                 375                 380                 
Arg Tyr Ser Pro Ser Thr Pro Thr Asp Gly Thr Thr Ile Thr Glu Ser
385                 390                 395                 400 
Ser Asn Leu Ser Glu Ile Glu Ser Arg Leu Pro Lys Ala Lys Leu Ile
                405                 410                 415     
Thr Leu Cys Lys His Glu Ser Ile Leu Lys Trp Met Cys Asn Cys Asp
            420                 425                 430         
His Gly Met Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu
        435                 440                 445             
Arg Pro Ile Pro Ser Ala Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys
    450                 455                 460                 
Ser Leu Glu Gly Trp Leu Ser Asn Ala Met Asn Asn Ile Pro Gln Arg
465                 470                 475                 480 
Met Ile Gln Thr Lys Val Ala Ala Val Ser Ala Phe Ala Gln Thr Leu
                485                 490                 495     
Arg Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val
            500                 505                 510         
Leu Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg
        515                 520                 525             
Val Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys
    530                 535                 540                 
Asp Asp Asn Met Val Gln Arg Leu Glu Thr Asp Phe Lys Met Thr Leu
545                 550                 555                 560 
Gln Gln Gln Ser Thr Leu Glu Gln Trp Ala Ala Trp Leu Asp Asn Val
                565                 570                 575     
Met Met Gln Ala Leu Lys Pro Tyr Glu Gly Arg Pro Ser Phe Pro Lys
            580                 585                 590         
Ala Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val
        595                 600                 605             
Ile Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His
    610                 615                 620                 
Leu Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His
625                 630                 635                 640 
Arg Val Ala Gln Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu
                645                 650                 655     
Val Arg Glu Ala Glu Arg Ala Val Thr His Trp Val Ile Lys Asn Lys
            660                 665                 670         
Pro Glu Leu His Phe Ser Leu Asn Thr Leu Leu Ile Lys Thr Met Val
        675                 680                 685             
Pro Asn Gln Val Ser Leu Arg Ala Arg Arg Asp Cys Gly Val Ile Ala
    690                 695                 700                 
Arg Val Pro
705         


<210> 7061
<211> 749
<212> PRT
<213> Homo sapiens

<400> 7061
Met Gln Thr Ser Glu Thr Gly Ser Asp Thr Gly Ser Thr Val Thr Leu
 1               5                  10                  15      
Gln Thr Ser Val Ala Ser Gln Ala Ala Val Pro Thr Gln Val Val Gln
            20                  25                  30          
Gln Val Pro Val Gln Gln Gln Val Gln Gln Val Gln Thr Val Gln Gln
        35                  40                  45              
Val Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Ser Asp
    50                  55                  60                  
Thr Val Tyr Thr Asn Gly Ala Ile Arg Thr Thr Thr Tyr Pro Tyr Thr
65                  70                  75                  80  
Glu Thr Gln Met Tyr Ser Gln Asn Thr Gly Gly Asn Tyr Phe Asp Thr
                85                  90                  95      
Gln Gly Ser Ser Ala Gln Val Thr Thr Val Val Ser Ser His Ser Met
            100                 105                 110         
Val Gly Thr Gly Gly Ile Gln Met Gly Val Thr Gly Gly Gln Leu Ile
        115                 120                 125             
Ser Ser Ser Gly Gly Thr Tyr Leu Ile Gly Asn Ser Met Glu Asn Ser
    130                 135                 140                 
Gly His Ser Val Thr His Thr Thr Arg Ala Ser Pro Ala Thr Ile Glu
145                 150                 155                 160 
Met Ala Ile Glu Thr Leu Gln Lys Ser Asp Gly Leu Ser Thr His Arg
                165                 170                 175     
Ser Ser Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu
            180                 185                 190         
Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Thr Leu Tyr Asn His Tyr
        195                 200                 205             
Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser
    210                 215                 220                 
Phe Gly Lys Leu Ile Arg Ser Ile Phe Met Gly Leu Arg Thr Arg Arg
225                 230                 235                 240 
Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Val
                245                 250                 255     
Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Met Gln Tyr Met
            260                 265                 270         
Ala Met Arg Gln Gln Pro Met Gln Gln Lys Gln Arg Tyr Lys Pro Met
        275                 280                 285             
Gln Lys Val Asp Gly Val Ala Asp Gly Phe Thr Gly Ser Gly Gln Gln
    290                 295                 300                 
Thr Gly Thr Ser Val Glu Gln Thr Val Ile Ala Gln Ser Gln His His
305                 310                 315                 320 
Gln Gln Phe Leu Asp Ala Ser Arg Ala Leu Pro Glu Phe Gly Glu Val
                325                 330                 335     
Glu Ile Ser Ser Leu Pro Asp Gly Thr Thr Phe Glu Asp Ile Lys Ser
            340                 345                 350         
Leu Gln Ser Leu Tyr Arg Glu His Cys Glu Ala Ile Leu Asp Val Val
        355                 360                 365             
Val Asn Leu Gln Phe Ser Leu Ile Glu Lys Leu Trp Gln Thr Phe Trp
    370                 375                 380                 
Arg Tyr Ser Pro Ser Thr Pro Thr Asp Gly Thr Thr Ile Thr Glu Ser
385                 390                 395                 400 
Ser Asn Leu Ser Glu Ile Glu Ser Arg Leu Pro Lys Ala Lys Leu Ile
                405                 410                 415     
Thr Leu Cys Lys His Glu Ser Ile Leu Lys Trp Met Cys Asn Cys Asp
            420                 425                 430         
His Gly Met Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu
        435                 440                 445             
Arg Pro Ile Pro Ser Ala Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys
    450                 455                 460                 
Ser Leu Glu Gly Trp Leu Ser Asn Ala Met Asn Asn Ile Pro Gln Arg
465                 470                 475                 480 
Met Ile Gln Thr Lys Val Ala Ala Val Ser Ala Phe Ala Gln Thr Leu
                485                 490                 495     
Arg Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val
            500                 505                 510         
Leu Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg
        515                 520                 525             
Val Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys
    530                 535                 540                 
Asp Asp Asn Met Val Gln Arg Leu Glu Thr Asp Phe Lys Met Thr Leu
545                 550                 555                 560 
Gln Gln Gln Ser Thr Leu Glu Gln Trp Ala Ala Trp Leu Asp Asn Val
                565                 570                 575     
Met Met Gln Ala Leu Lys Pro Tyr Glu Gly Arg Pro Ser Phe Pro Lys
            580                 585                 590         
Ala Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val
        595                 600                 605             
Ile Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His
    610                 615                 620                 
Leu Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His
625                 630                 635                 640 
Arg Val Ala Gln Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu
                645                 650                 655     
Phe Gly Asp Leu Asn Ala Val Ser Pro Gly Asn Leu Asp Lys Asp Glu
            660                 665                 670         
Gly Ser Glu Val Glu Ser Glu Met Asp Glu Glu Leu Asp Asp Ser Ser
        675                 680                 685             
Glu Pro Gln Ala Lys Arg Glu Lys Thr Glu Leu Ser Gln Ala Phe Pro
    690                 695                 700                 
Val Gly Cys Met Gln Pro Val Leu Glu Thr Gly Val Gln Pro Ser Leu
705                 710                 715                 720 
Leu Asn Pro Ile His Ser Glu His Ile Val Thr Ser Thr Gln Thr Ile
                725                 730                 735     
Arg Gln Cys Ser Ala Thr Gly Asn Thr Tyr Thr Ala Val
            740                 745                 


<210> 7062
<211> 463
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 251
<223> Xaa = Any Amino Acid

<400> 7062
Met Leu Val Gly Ser Trp Ser Ser Val Ser Gly Leu Arg Lys Arg Glu
 1               5                  10                  15      
Cys Arg Ser Ser Ala Lys Pro Glu Ser Cys Pro Leu Val Leu Phe Pro
            20                  25                  30          
Gly Gln His Glu Leu His His Ser Leu His Leu Phe His Leu Leu Pro
        35                  40                  45              
Phe Pro Gly Leu Cys Pro Gly Ala Gln Leu His Ala Arg Pro Val Ser
    50                  55                  60                  
Ser Thr Ala Ser Val Tyr Ala Gly Ala Gly Gly Ser Gly Ser Gly Asn
65                  70                  75                  80  
Ser Val Ser Cys Ser Thr Ser Phe Arg Gly Gly Leu Gly Ser Gly Ala
                85                  90                  95      
Leu Ala Ala Gly Met Ala Gly Gly Leu Ala Gly Met Gly Ser Ile Gln
            100                 105                 110         
Asn Lys Glu Thr Met Gln Ser Leu Asn Asn Arg Leu Ala Ser Tyr Leu
        115                 120                 125             
Asp Arg Met Arg Ser Leu Glu Thr Glu Asn Trp Lys Leu Glu Ser Lys
    130                 135                 140                 
Ile Arg Lys His Leu Glu Lys Lys Gly Pro Gln Ile Arg His Trp Ser
145                 150                 155                 160 
His Tyr Phe Lys Thr Ile Gln Asp Leu Arg Ala Gln Asn Leu Ala Asn
                165                 170                 175     
Thr Val Asp Asn Ala Arg Ile Val Leu Gln Thr Asp Asn Ala Cys Leu
            180                 185                 190         
Ala Ala Asp Asp Phe Arg Val Lys Tyr Glu Thr Glu Leu Thr Met Cys
        195                 200                 205             
Gln Ser Val Glu Ser Asp Ile His Gly Leu Arg Lys Val Thr Asp Asp
    210                 215                 220                 
Thr Asn Val Thr Trp Leu Gln Leu Glu Thr Glu Ile Glu Ala Leu Lys
225                 230                 235                 240 
Glu Glu Leu Leu Leu Met Lys Lys Asn His Xaa Glu Glu Leu Lys Gly
                245                 250                 255     
Leu Gln Val Gln Ile Ala Ser Ser Gly Leu Thr Val Glu Val Asp Ala
            260                 265                 270         
Pro Lys Ser Gln Asp His Ser Lys Ile Met Ala Asp Ile Gln Ala Gln
        275                 280                 285             
Tyr Asn Glu Leu Ser Arg Lys Asn Arg Glu Glu Leu Asp Lys Tyr Trp
    290                 295                 300                 
Ser Gln Gln Ile Glu Glu Ser Ser Thr Val Val Thr Thr Gln Ser Thr
305                 310                 315                 320 
Glu Val Gly Ala Ala Glu Met Thr Leu Thr Lys Leu Arg Arg Thr Val
                325                 330                 335     
Gln Ser Leu Glu Ile Asp Leu Asp Ser Met Arg Asn Leu Lys Ala Ser
            340                 345                 350         
Leu Glu Asn Ser Leu Arg Glu Val Glu Ala Arg Tyr Ala Leu Gln Met
        355                 360                 365             
Glu Gln Leu Asn Gly Ile Leu Leu His Leu Glu Ser Glu Leu Ala Gln
    370                 375                 380                 
Thr Arg Ala Glu Gly Gln His Gln Ala Gln Glu Tyr Glu Ala Leu Leu
385                 390                 395                 400 
Asn Ile Lys Val Lys Leu Glu Ala Glu Ile Ala Thr Tyr Asn Asn Leu
                405                 410                 415     
Leu Glu Asp Gly Lys Asn Phe Asn Leu Leu Asn Ala Leu Asp Ser Ser
            420                 425                 430         
Thr Ser Met Gln Thr Ile Gln Lys Thr Asn Ser Arg Trp Ile Val Asp
        435                 440                 445             
Gly Lys Val Val Ser Glu Thr Asn His Thr Lys Val Leu Arg His
    450                 455                 460             


<210> 7063
<211> 1484
<212> PRT
<213> Homo sapiens

<400> 7063
Ile Met Pro Ser Glu Gln Lys Gln Leu Phe Cys Asp Glu Lys Gln Thr
 1               5                  10                  15      
Thr Leu Lys Lys Asp Tyr Asp Val Lys Asn Glu Ile Val Asp Arg Ser
            20                  25                  30          
Ala Pro Lys Pro Lys Ile Ser Gly Ser Ile His Tyr Ala Leu Lys Asn
        35                  40                  45              
Val Lys Ile Asp Leu Pro Lys Ile Asn Ile Pro Asn Glu Val Leu Leu
    50                  55                  60                  
Lys His Glu Val Asp Lys Tyr Arg Lys Leu Phe Gln Ser Lys Gln Gln
65                  70                  75                  80  
Thr Ala Arg Lys Ser Ile Ser Ile Lys Thr Val Ser Cys Val Glu Glu
                85                  90                  95      
Cys Thr Leu Leu His Lys Ser Glu Arg Ala Glu Glu Glu Gly Val Lys
            100                 105                 110         
Met Ser Ala Lys Ile Leu Asn Phe Ser Cys Leu Lys Cys Arg Asp Asn
        115                 120                 125             
Thr Arg Tyr Ser Pro Asn Asp Leu Gln Lys His Phe Gln Met Trp His
    130                 135                 140                 
His Gly Glu Leu Pro Ser Tyr Pro Cys Glu Met Cys Asn Phe Ser Ala
145                 150                 155                 160 
Asn Asp Phe Gln Val Phe Lys Gln His Arg Arg Thr His Arg Ser Thr
                165                 170                 175     
Leu Val Lys Cys Asp Ile Cys Asn Asn Glu Ser Val Tyr Thr Leu Leu
            180                 185                 190         
Asn Leu Thr Lys His Phe Thr Ser Thr His Cys Val Asn Gly Asn Phe
        195                 200                 205             
Gln Cys Glu Lys Cys Lys Phe Ser Thr Gln Asp Val Gly Thr Phe Val
    210                 215                 220                 
Gln His Ile His Arg His Asn Glu Ile His Tyr Lys Cys Gly Lys Cys
225                 230                 235                 240 
His His Val Cys Phe Thr Lys Gly Glu Leu Gln Lys His Leu His Ile
                245                 250                 255     
His Ser Gly Thr Phe Pro Phe Thr Cys Gln Tyr Cys Ser Tyr Gly Ala
            260                 265                 270         
Thr Arg Arg Glu His Leu Val Arg His Val Ile Thr Leu His Lys Glu
        275                 280                 285             
His Leu Tyr Ala Lys Glu Lys Leu Glu Lys Asp Lys Tyr Glu Lys Arg
    290                 295                 300                 
Met Ala Lys Thr Ser Ala Gly Leu Lys Leu Ile Leu Lys Arg Tyr Lys
305                 310                 315                 320 
Ile Gly Ala Ser Arg Lys Thr Phe Trp Lys Arg Lys Lys Ile Asn Ser
                325                 330                 335     
Gly Ser Asp Arg Ser Ile Glu Lys Asn Thr Gln Val Leu Lys Lys Met
            340                 345                 350         
Asn Lys Thr Gln Thr Lys Ser Glu Asp Gln Ser His Val Val Gln Glu
        355                 360                 365             
His Leu Ser Glu Glu Lys Asp Glu Arg Leu His Cys Glu Asn Asn Asp
    370                 375                 380                 
Lys Ala Pro Glu Ser Glu Ser Glu Lys Pro Thr Pro Leu Ser Thr Gly
385                 390                 395                 400 
Gln Gly Asn Arg Ala Glu Glu Gly Pro Asn Ala Ser Ser Gly Phe Met
                405                 410                 415     
Lys Thr Ala Val Leu Gly Pro Thr Leu Lys Asn Val Met Met Lys Asn
            420                 425                 430         
Asn Lys Leu Ala Val Ser Pro Asn Tyr Asn Ala Thr Phe Met Gly Phe
        435                 440                 445             
Lys Met Met Asp Gly Lys Gln His Ile Val Leu Lys Leu Val Pro Ile
    450                 455                 460                 
Lys Gln Asn Val Cys Ser Pro Gly Ser Gln Ser Gly Ala Ala Lys Asp
465                 470                 475                 480 
Gly Thr Ala Asn Leu Gln Pro Gln Thr Leu Asp Thr Asn Gly Phe Leu
                485                 490                 495     
Thr Gly Val Thr Thr Glu Leu Asn Asp Thr Val Tyr Met Lys Ala Ala
            500                 505                 510         
Thr Pro Phe Ser Cys Ser Ser Ser Ile Leu Ser Gly Lys Ala Ser Ser
        515                 520                 525             
Glu Lys Glu Met Thr Leu Ile Ser Gln Arg Asn Asn Met Leu Gln Thr
    530                 535                 540                 
Met Asp Tyr Glu Lys Ser Val Ser Ser Leu Ser Ala Thr Ser Glu Leu
545                 550                 555                 560 
Val Thr Ala Ser Val Asn Leu Thr Thr Lys Phe Glu Thr Arg Asp Asn
                565                 570                 575     
Val Asp Phe Trp Gly Asn His Leu Thr Gln Ser His Pro Glu Val Leu
            580                 585                 590         
Gly Thr Thr Ile Lys Ser Pro Asp Lys Val Asn Cys Val Ala Lys Pro
        595                 600                 605             
Asn Ala Tyr Asn Ser Gly Asp Met His Asn Tyr Cys Ile Asn Tyr Gly
    610                 615                 620                 
Asn Cys Glu Leu Pro Val Glu Ser Ser Asn Gln Gly Ser Leu Pro Phe
625                 630                 635                 640 
His Asn Tyr Ser Lys Val Asn Asn Ser Asn Lys Arg Arg Arg Phe Ser
                645                 650                 655     
Gly Thr Ala Val Tyr Glu Asn Pro Gln Arg Glu Ser Ser Ser Ser Lys
            660                 665                 670         
Thr Val Val Gln Gln Pro Ile Ser Glu Ser Phe Leu Ser Leu Val Arg
        675                 680                 685             
Gln Glu Ser Ser Lys Pro Asp Ser Leu Leu Ala Ser Ile Ser Leu Leu
    690                 695                 700                 
Asn Asp Lys Asp Gly Thr Leu Lys Ala Lys Ser Glu Ile Glu Glu Gln
705                 710                 715                 720 
Tyr Val Leu Glu Lys Gly Gln Asn Ile Asp Gly Gln Asn Leu Tyr Ser
                725                 730                 735     
Asn Glu Asn Gln Asn Leu Glu Cys Ala Thr Glu Lys Ser Lys Trp Glu
            740                 745                 750         
Asp Phe Ser Asn Val Asp Ser Pro Met Met Pro Arg Ile Thr Ser Val
        755                 760                 765             
Phe Ser Leu Gln Ser Gln Gln Ala Ser Glu Phe Leu Pro Pro Glu Val
    770                 775                 780                 
Asn Gln Leu Leu Gln Asp Val Leu Lys Ile Lys Pro Asp Val Lys Gln
785                 790                 795                 800 
Asp Ser Ser Asn Thr Pro Asn Lys Gly Leu Pro Leu His Cys Asp Gln
                805                 810                 815     
Ser Phe Gln Lys His Glu Arg Glu Gly Lys Ile Val Glu Ser Ser Lys
            820                 825                 830         
Asp Phe Lys Val Gln Gly Ile Phe Pro Val Pro Pro Gly Ser Val Gly
        835                 840                 845             
Ile Asn Val Pro Thr Asn Asp Leu Asn Leu Lys Phe Gly Lys Glu Lys
    850                 855                 860                 
Gln Val Ser Ser Ile Pro Gln Asp Val Arg Asp Ser Glu Lys Met Pro
865                 870                 875                 880 
Arg Ile Ser Gly Phe Gly Thr Leu Leu Lys Thr Gln Ser Asp Ala Ile
                885                 890                 895     
Ile Thr Gln Gln Leu Val Lys Asp Lys Leu Arg Ala Thr Thr Gln Asn
            900                 905                 910         
Leu Gly Ser Phe Tyr Met Gln Ser Pro Leu Leu Asn Ser Glu Gln Lys
        915                 920                 925             
Lys Thr Ile Ile Val Gln Thr Ser Lys Gly Phe Leu Ile Pro Leu Asn
    930                 935                 940                 
Ile Thr Asn Lys Pro Gly Leu Pro Val Ile Pro Gly Asn Ala Leu Pro
945                 950                 955                 960 
Leu Val Asn Ser Gln Gly Ile Pro Ala Ser Leu Phe Val Asn Lys Lys
                965                 970                 975     
Pro Gly Met Val Leu Thr Leu Asn Asn Gly Lys Leu Glu Gly Val Ser
            980                 985                 990         
Ala Val Lys Thr Glu Gly Ala Pro Ala Arg Gly Thr Val Thr Lys Glu
        995                 1000                1005            
Pro Cys Lys Thr Pro Ile Leu Lys Val Glu Pro Asn Asn Asn Cys Leu
    1010                1015                1020                
Thr Pro Gly Leu Cys Ser Ser Ile Gly Ser Cys Leu Ser Met Lys Ser
1025                1030                1035                1040
Ser Ser Glu Asn Thr Leu Pro Leu Lys Gly Pro Tyr Ile Leu Lys Pro
                1045                1050                1055    
Thr Ser Ser Val Lys Ala Val Leu Ile Pro Asn Met Leu Ser Glu Gln
            1060                1065                1070        
Gln Ser Thr Lys Leu Asn Ile Ser Asp Ser Val Lys Gln Gln Asn Glu
        1075                1080                1085            
Ile Phe Pro Lys Pro Pro Leu Tyr Thr Phe Leu Pro Asp Gly Lys Gln
    1090                1095                1100                
Ala Val Phe Leu Lys Cys Val Met Pro Asn Lys Thr Glu Leu Leu Lys
1105                1110                1115                1120
Pro Lys Leu Val Gln Asn Ser Thr Tyr Gln Asn Ile Gln Pro Lys Lys
                1125                1130                1135    
Pro Glu Gly Thr Pro Gln Arg Ile Leu Leu Lys Ile Phe Asn Pro Val
            1140                1145                1150        
Leu Asn Val Thr Ala Ala Asn Asn Leu Ser Val Ser Asn Ser Ala Ser
        1155                1160                1165            
Ser Leu Gln Lys Asp Asn Val Pro Ser Asn Gln Ile Ile Gly Gly Glu
    1170                1175                1180                
Gln Lys Glu Pro Glu Ser Arg Asp Ala Leu Pro Phe Leu Leu Asp Asp
1185                1190                1195                1200
Leu Met Pro Ala Asn Glu Ile Val Ile Thr Ser Thr Ala Thr Cys Pro
                1205                1210                1215    
Glu Ser Ser Glu Glu Pro Ile Cys Val Ser Asp Cys Ser Glu Ser Arg
            1220                1225                1230        
Val Leu Arg Cys Lys Thr Asn Cys Arg Ile Glu Arg Asn Phe Asn Arg
        1235                1240                1245            
Lys Lys Thr Ser Lys Lys Ile Phe Ser Lys Thr Lys Thr His Gly Ser
    1250                1255                1260                
Lys Asp Ser Glu Thr Ala Phe Val Ser Arg Asn Arg Asn Cys Lys Arg
1265                1270                1275                1280
Lys Cys Arg Asp Ser Tyr Gln Glu Pro Pro Arg Arg Lys Ala Thr Leu
                1285                1290                1295    
His Arg Lys Cys Lys Glu Lys Ala Lys Pro Glu Asp Val Arg Glu Thr
            1300                1305                1310        
Phe Gly Phe Ser Arg Pro Arg Leu Ser Lys Asp Ser Ile Arg Thr Leu
        1315                1320                1325            
Arg Leu Phe Pro Phe Ser Ser Lys Gln Leu Val Lys Cys Pro Arg Arg
    1330                1335                1340                
Asn Gln Pro Val Val Val Leu Asn His Pro Asp Ala Asp Ala Pro Glu
1345                1350                1355                1360
Val Val Ser Val Met Lys Thr Ile Ala Lys Phe Asn Gly His Val Leu
                1365                1370                1375    
Lys Val Ser Leu Ser Lys Arg Thr Ile Asn Ala Leu Leu Lys Pro Val
            1380                1385                1390        
Cys Tyr Asn Pro Pro Lys Thr Thr Tyr Asp Asp Phe Ser Lys Arg His
        1395                1400                1405            
Lys Thr Phe Lys Pro Val Ser Ser Val Lys Glu Arg Phe Val Leu Lys
    1410                1415                1420                
Leu Thr Leu Lys Lys Thr Ser Lys Asn Asn Tyr Gln Ile Val Lys Thr
1425                1430                1435                1440
Thr Ser Glu Asn Ile Leu Lys Ala Lys Phe Asn Cys Trp Phe Cys Gly
                1445                1450                1455    
Arg Val Phe Asp Asn Gln Asp Thr Trp Ala Gly His Gly Gln Arg His
            1460                1465                1470        
Leu Met Glu Ala Thr Arg Asp Trp Asn Met Leu Glu
        1475                1480                


<210> 7064
<211> 514
<212> PRT
<213> Homo sapiens

<400> 7064
Met Ala Asp Ser Gly Leu Asp Lys Lys Ser Thr Lys Cys Pro Asp Cys
 1               5                  10                  15      
Ser Ser Ala Ser Gln Lys Asp Val Leu Cys Val Cys Ser Ser Lys Thr
            20                  25                  30          
Arg Val Pro Pro Val Leu Val Val Glu Met Ser Gln Thr Ser Ser Ile
        35                  40                  45              
Gly Ser Ala Glu Ser Leu Ile Ser Leu Glu Arg Lys Lys Glu Lys Asn
    50                  55                  60                  
Ile Asn Arg Asp Ile Thr Ser Arg Lys Asp Leu Pro Ser Arg Thr Ser
65                  70                  75                  80  
Asn Val Glu Arg Lys Ala Ser Gln Gln Gln Trp Gly Arg Gly Asn Phe
                85                  90                  95      
Thr Glu Gly Lys Val Pro His Ile Arg Ile Glu Asn Gly Ala Ala Ile
            100                 105                 110         
Glu Glu Ile Tyr Thr Phe Gly Arg Ile Leu Gly Lys Gly Ser Phe Gly
        115                 120                 125             
Ile Val Ile Glu Ala Thr Asp Lys Glu Thr Glu Thr Lys Trp Ala Ile
    130                 135                 140                 
Lys Lys Val Asn Lys Glu Lys Ala Gly Ser Ser Ala Val Lys Leu Leu
145                 150                 155                 160 
Glu Arg Glu Val Asn Ile Leu Lys Ser Val Lys His Glu His Ile Ile
                165                 170                 175     
His Leu Glu Gln Val Phe Glu Thr Pro Lys Lys Met Tyr Leu Val Met
            180                 185                 190         
Glu Leu Cys Glu Asp Gly Glu Leu Lys Glu Ile Leu Asp Arg Lys Gly
        195                 200                 205             
His Phe Ser Glu Asn Glu Thr Arg Trp Ile Ile Gln Ser Leu Ala Ser
    210                 215                 220                 
Ala Ile Ala Tyr Leu His Asn Asn Asp Ile Val His Arg Asp Leu Lys
225                 230                 235                 240 
Leu Glu Asn Ile Met Val Lys Ser Ser Leu Ile Asp Asp Asn Asn Glu
                245                 250                 255     
Ile Asn Leu Asn Ile Lys Val Thr Asp Phe Gly Leu Ala Val Lys Lys
            260                 265                 270         
Gln Ser Arg Ser Glu Ala Met Leu Gln Ala Thr Cys Gly Thr Pro Ile
        275                 280                 285             
Tyr Met Ala Pro Glu Val Ile Ser Ala His Asp Tyr Ser Gln Gln Cys
    290                 295                 300                 
Asp Ile Trp Ser Ile Gly Val Val Met Tyr Met Leu Leu Arg Gly Glu
305                 310                 315                 320 
Pro Pro Phe Leu Ala Ser Ser Glu Glu Lys Leu Phe Glu Leu Ile Arg
                325                 330                 335     
Lys Gly Glu Leu His Phe Glu Asn Ala Val Trp Asn Ser Ile Ser Asp
            340                 345                 350         
Cys Ala Lys Ser Val Leu Lys Gln Leu Met Lys Val Asp Pro Ala His
        355                 360                 365             
Arg Ile Thr Ala Lys Glu Leu Leu Asp Asn Gln Trp Leu Thr Gly Asn
    370                 375                 380                 
Lys Leu Ser Ser Val Arg Pro Thr Asn Val Leu Glu Met Met Lys Glu
385                 390                 395                 400 
Trp Lys Asn Asn Pro Glu Ser Val Glu Glu Asn Thr Thr Glu Glu Lys
                405                 410                 415     
Asn Lys Pro Ser Thr Glu Glu Lys Leu Lys Ser Tyr Gln Pro Trp Gly
            420                 425                 430         
Asn Val Pro Asp Ala Asn Tyr Thr Ser Asp Glu Glu Glu Glu Lys Gln
        435                 440                 445             
Ser Thr Ala Tyr Glu Lys Gln Phe Pro Ala Thr Ser Lys Asp Asn Phe
    450                 455                 460                 
Asp Met Cys Ser Ser Ser Phe Thr Ser Ser Lys Leu Leu Pro Ala Glu
465                 470                 475                 480 
Ile Lys Gly Glu Met Glu Lys Thr Pro Val Thr Pro Ser Gln Gly Thr
                485                 490                 495     
Ala Thr Lys Tyr Pro Ala Lys Ser Gly Ala Leu Ser Arg Thr Lys Lys
            500                 505                 510         
Lys Leu
        


<210> 7065
<211> 706
<212> PRT
<213> Homo sapiens

<400> 7065
Ser Lys Gln Leu His Phe Leu Leu Ser Pro Lys His Tyr Tyr Arg Ile
 1               5                  10                  15      
Ser His Ile Arg Leu Gln Arg Asp Phe His Thr Asn Glu Val Ile Cys
            20                  25                  30          
Lys Asp Lys Asn Glu Thr His Thr Gly Arg Lys His Cys Tyr Ser Pro
        35                  40                  45              
Asp Asn His Cys Leu His Ile Arg Ile Leu Lys Pro Ser Thr Pro Thr
    50                  55                  60                  
Pro Lys Gly Leu Thr Lys Met Ser Ile Cys Met Ser His Ile Lys Ser
65                  70                  75                  80  
Thr Ser Thr Ile Ser Lys Asp Val Phe Gly Asn Gln Asn Glu Ile Ile
                85                  90                  95      
Ser Arg Leu Ala Gln Ile Lys Arg Asn Ser His Gln Leu Ile Leu Leu
            100                 105                 110         
Arg Lys Val Ser Asn His Asp Trp Leu Lys Gln Thr Lys Lys Val Lys
        115                 120                 125             
Gln Gly Ile Lys Ser Leu Lys Lys Asn Leu Thr Asn Lys Lys Lys Tyr
    130                 135                 140                 
Pro Leu Pro Lys Glu Lys Cys Gln Ile Arg Arg Lys Glu Asp Ile Ser
145                 150                 155                 160 
Ser Leu Leu Tyr Tyr Met Thr Ile Ile Ala Thr Lys Leu Lys Lys Pro
                165                 170                 175     
Phe Tyr Phe Ser Ser Asn Tyr Val Asn Ser Tyr Phe Lys Cys Gly Glu
            180                 185                 190         
Asn Val Ser Gln Lys Asn Arg Glu Lys Lys Lys Lys Phe Gln Asp Ile
        195                 200                 205             
Ser Glu Leu Glu Gly Lys Gln Val Glu Glu Gly Lys Leu Ser Ser Pro
    210                 215                 220                 
Asp Leu Gly Met Leu Thr Asp Lys Ser Gly Ser Glu Ser Ser Leu Asp
225                 230                 235                 240 
Thr Val Glu Asn Pro Ser Asn Pro Ile Ala Ile Leu Glu Val Leu Leu
                245                 250                 255     
Val Ser Thr Lys Val Leu Leu Thr Phe Phe Phe Ile Pro Val Lys Leu
            260                 265                 270         
Tyr Asn Leu Leu Arg Trp Asn Ile Gly Gly Leu Val Pro Lys Leu Asn
        275                 280                 285             
Tyr Asp Leu Lys Arg His Leu Glu Lys Glu Glu Lys Pro Thr Lys Thr
    290                 295                 300                 
Glu Gln Ala Ile Ser Lys Asp Lys Asn Ala Glu Lys Asn Asn Arg Leu
305                 310                 315                 320 
Ser Leu Gln Gly Glu Ile Ile Ile Ala Ile Ile Asp Asn Arg Thr Trp
                325                 330                 335     
Val Leu Val Gln Val Leu Arg Lys Thr Thr Asp Leu Lys Phe Cys Ile
            340                 345                 350         
Thr Gly Val Glu Glu Leu Asn Phe His His Leu Glu Tyr Ile Glu Gly
        355                 360                 365             
Asn Val Ser Val Lys Glu Arg Ile Ile Pro Tyr Leu Phe Trp Leu Arg
    370                 375                 380                 
Leu Lys Val Lys His Phe Arg Leu His Leu Asp Asn Phe Ala Leu Ile
385                 390                 395                 400 
Ala Tyr Val His Pro Val Lys Gly Arg Gly Ile Pro Ile Phe Ile Ile
                405                 410                 415     
Glu Asp Gly Gly Thr Ser Tyr Val Val Ala Leu Gln Ile Leu Cys Lys
            420                 425                 430         
Leu Val Glu Leu Thr Gln Lys Pro Val Asp Gln Pro Phe Asp Tyr Ile
        435                 440                 445             
Cys Gly Val Ser Thr Gly Ala Ile Leu Ala Phe Met Ser Gly Phe Phe
    450                 455                 460                 
His Met Ser Leu Asp Glu Cys Glu Lys Tyr Lys Thr Leu Gly Ser Asp
465                 470                 475                 480 
Val Phe Ser Gln Asn Phe Ile Val Gly Lys Val Lys Met Ser Trp Ser
                485                 490                 495     
His Ala Phe Tyr Arg Ser Gln Arg Trp Glu Lys Ile Leu Lys Asn Arg
            500                 505                 510         
Met Gly Phe Thr Leu Leu Met Ala Thr Ala Arg Asn Pro Thr Cys Leu
        515                 520                 525             
Lys Val Thr Ala Ile Ser Thr Ile Val Asn Arg Gly Ile Thr Pro Lys
    530                 535                 540                 
Leu Ile Asn Tyr Asp His Phe Ala Gly Ile Asn Cys His Phe Arg Gly
545                 550                 555                 560 
Ser Gln Tyr Lys Met Trp Gln Ala Ile Arg Ala Ser Ser Ala Ala Pro
                565                 570                 575     
Gly Tyr Phe Ala Glu Tyr Thr Leu Gly Asn Asp Leu His Gln Gly Gly
            580                 585                 590         
Gly Leu Leu Leu Asn Asn Tyr Leu Ala Leu Ala Met His Glu Tyr Lys
        595                 600                 605             
Cys His Trp Pro Asp Ile Pro Leu Glu Cys Thr Val Cys Leu Gly Thr
    610                 615                 620                 
Gly His Ser Glu Ser Asp Met Lys Asn Thr Val Ile His Thr Ser Leu
625                 630                 635                 640 
Lys Thr Lys Leu Ser Asn Val Ile Asn Ser Ala Thr Asp Ile Glu Ala
                645                 650                 655     
Val Cys Ile Met Leu Asp Val Leu Leu Pro Pro Asp Thr Tyr Phe Ile
            660                 665                 670         
Phe Asn Pro Glu Met Cys Glu Asn Asn Pro Asp Glu Ser Gln Asn Glu
        675                 680                 685             
Lys Leu Asp Gln Leu Lys Leu Glu Gly Leu Lys Tyr Ile Glu Lys Asn
    690                 695                 700                 
Glu Lys
705     


<210> 7066
<211> 253
<212> PRT
<213> Homo sapiens

<400> 7066
Met Gly Glu Leu Pro Gly Ser Glu Gly Met Trp Glu Asn Cys Pro Leu
 1               5                  10                  15      
Gly Trp Val Lys Lys Lys Ala Ser Gly Thr Leu Ala Pro Leu Asp Phe
            20                  25                  30          
Leu Leu Gln Arg Lys Arg Leu Trp Leu Trp Ala Ser Glu Pro Val Arg
        35                  40                  45              
Pro Gln Pro Gln Gly Ile His Arg Phe Arg Glu Ala Arg Arg Gln Phe
    50                  55                  60                  
Cys Arg Met Arg Gly Ser Arg Leu Thr Gly Gly Arg Lys Gly Phe Gly
65                  70                  75                  80  
Ser Ser Gly Leu Arg Phe Gly Arg Asp Gly Phe Ser Glu Glu Val Met
                85                  90                  95      
Pro Gln Pro Val Leu Lys Ala Met Arg Cys Ala Glu Gly Ala Trp Trp
            100                 105                 110         
Phe Ser Pro Asp Gly Pro Ala Gly Ser Ala Ala Ser Ile Trp Pro Ala
        115                 120                 125             
Glu Gly Ala Glu Arg Leu Pro Gly Gln Leu Gly Arg Asp Arg Leu Glu
    130                 135                 140                 
Val Val Tyr Ser Val Pro Asp Asn Val Pro Gly Gln Asn Gly Ser Arg
145                 150                 155                 160 
Arg Pro Leu Val Cys Lys Ile Thr Gly Lys Cys Leu Ser Val Cys Ser
                165                 170                 175     
Glu Glu Asn Ala Lys Ala Gly Gly Cys Ser Ala Phe Pro Leu Leu Leu
            180                 185                 190         
Ser Gln Leu Gly Ala Arg Met Thr Gly Arg Glu His Ala His Lys Gly
        195                 200                 205             
Pro Glu Leu Thr Thr Pro Asp Ser Gly Leu Pro Arg Pro Pro Asn Pro
    210                 215                 220                 
Ala Leu Ala Gly Phe Arg Ala Leu Ala Gln His Ser Pro Pro Leu Gly
225                 230                 235                 240 
Thr Ser Thr Pro Ser Ala Val Leu Leu Ser Ala Ala Thr
                245                 250             


<210> 7067
<211> 510
<212> PRT
<213> Homo sapiens

<400> 7067
Met Ala Ala Glu Leu Val Glu Ala Lys Asn Met Val Met Ser Phe Arg
 1               5                  10                  15      
Val Ser Asp Leu Gln Met Leu Leu Gly Phe Val Gly Arg Ser Lys Ser
            20                  25                  30          
Gly Leu Lys His Glu Leu Val Thr Arg Ala Leu Gln Leu Val Gln Phe
        35                  40                  45              
Asp Cys Ser Pro Glu Leu Phe Lys Lys Ile Lys Glu Leu Tyr Glu Thr
    50                  55                  60                  
Arg Tyr Ala Lys Lys Asn Ser Glu Pro Ala Pro Gln Pro His Arg Pro
65                  70                  75                  80  
Leu Asp Pro Leu Thr Met His Ser Thr Tyr Asp Arg Ala Gly Ala Val
                85                  90                  95      
Pro Arg Thr Pro Leu Ala Gly Pro Asn Ile Asp Tyr Pro Val Leu Tyr
            100                 105                 110         
Gly Lys Tyr Leu Asn Gly Leu Gly Arg Leu Pro Ala Lys Thr Leu Lys
        115                 120                 125             
Pro Glu Val Arg Leu Val Lys Leu Pro Phe Phe Asn Met Leu Asp Glu
    130                 135                 140                 
Leu Leu Lys Pro Thr Glu Leu Val Pro Gln Asn Asn Glu Lys Leu Gln
145                 150                 155                 160 
Glu Ser Pro Cys Ile Phe Ala Leu Thr Pro Arg Gln Val Glu Leu Ile
                165                 170                 175     
Arg Asn Ser Arg Glu Leu Gln Pro Gly Val Lys Ala Val Gln Val Val
            180                 185                 190         
Leu Arg Ile Cys Tyr Ser Asp Thr Ser Cys Pro Gln Glu Asp Gln Tyr
        195                 200                 205             
Pro Pro Asn Ile Ala Val Lys Val Asn His Ser Tyr Cys Ser Val Pro
    210                 215                 220                 
Gly Tyr Tyr Pro Ser Asn Lys Pro Gly Val Glu Pro Lys Arg Pro Cys
225                 230                 235                 240 
Arg Pro Ile Asn Leu Thr His Leu Met Tyr Leu Ser Ser Ala Thr Asn
                245                 250                 255     
Arg Ile Thr Val Thr Trp Gly Asn Tyr Gly Lys Ser Tyr Ser Val Ala
            260                 265                 270         
Leu Tyr Leu Val Arg Gln Leu Thr Ser Ser Glu Leu Leu Gln Arg Leu
        275                 280                 285             
Lys Thr Ile Gly Val Lys His Pro Glu Leu Cys Lys Ala Leu Val Lys
    290                 295                 300                 
Glu Lys Leu Arg Leu Asp Pro Asp Ser Glu Ile Ala Thr Thr Gly Val
305                 310                 315                 320 
Arg Val Ser Leu Ile Cys Pro Leu Val Lys Met Arg Leu Ser Val Pro
                325                 330                 335     
Cys Arg Ala Glu Thr Cys Ala His Leu Gln Cys Phe Asp Ala Val Phe
            340                 345                 350         
Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Met Cys Pro Val Cys
        355                 360                 365             
Asp Lys Pro Ala Pro Tyr Asp Gln Leu Ile Ile Asp Gly Leu Leu Ser
    370                 375                 380                 
Lys Ile Leu Ser Glu Cys Glu Asp Ala Asp Glu Ile Glu Tyr Leu Val
385                 390                 395                 400 
Asp Gly Ser Trp Cys Pro Ile Arg Ala Glu Lys Glu Arg Ser Cys Ser
                405                 410                 415     
Pro Gln Gly Ala Ile Leu Val Leu Gly Pro Ser Asp Ala Asn Gly Leu
            420                 425                 430         
Leu Pro Ala Pro Ser Val Asn Gly Ser Gly Ala Leu Gly Ser Thr Gly
        435                 440                 445             
Gly Gly Gly Pro Val Gly Ser Met Glu Asn Gly Lys Pro Gly Ala Asp
    450                 455                 460                 
Val Val Asp Leu Thr Leu Asp Ser Ser Ser Ser Ser Glu Asp Glu Glu
465                 470                 475                 480 
Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Gly Pro Arg Pro
                485                 490                 495     
Lys Arg Arg Cys Pro Phe Gln Lys Gly Leu Val Pro Ala Cys
            500                 505                 510 


<210> 7068
<211> 826
<212> PRT
<213> Homo sapiens

<400> 7068
Met Asn Ile Gln Glu Gln Gly Phe Pro Leu Asp Leu Gly Ala Ser Phe
 1               5                  10                  15      
Thr Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu Leu
            20                  25                  30          
Val Ser Thr Asp Pro Arg Pro Ala Ser Tyr Ser Phe Cys Ser Gly Lys
        35                  40                  45              
Gly Val Gly Ile Lys Gly Glu Thr Ser Thr Ala Thr Pro Arg Arg Ser
    50                  55                  60                  
Asp Leu Asp Leu Gly Tyr Glu Pro Glu Gly Ser Ala Ser Pro Thr Pro
65                  70                  75                  80  
Pro Tyr Leu Lys Trp Ala Glu Ser Leu His Ser Leu Leu Asp Asp Gln
                85                  90                  95      
Asp Gly Ile Ser Leu Phe Arg Thr Phe Leu Lys Gln Glu Gly Cys Ala
            100                 105                 110         
Asp Leu Leu Asp Phe Trp Phe Ala Cys Thr Gly Phe Arg Lys Leu Glu
        115                 120                 125             
Pro Cys Asp Ser Asn Glu Glu Lys Arg Leu Lys Leu Ala Arg Ala Ile
    130                 135                 140                 
Tyr Arg Lys Tyr Ile Leu Asp Asn Asn Gly Ile Val Ser Arg Gln Thr
145                 150                 155                 160 
Lys Pro Ala Thr Lys Ser Phe Ile Lys Gly Cys Ile Met Lys Gln Leu
                165                 170                 175     
Ile Asp Pro Ala Met Phe Asp Gln Ala Gln Thr Glu Ile Gln Ala Thr
            180                 185                 190         
Met Glu Glu Asn Thr Tyr Pro Ser Phe Leu Lys Ser Asp Ile Tyr Leu
        195                 200                 205             
Glu Tyr Thr Arg Thr Gly Ser Glu Ser Pro Lys Val Cys Ser Asp Gln
    210                 215                 220                 
Ser Ser Gly Ser Gly Thr Gly Lys Gly Ile Ser Gly Tyr Leu Pro Thr
225                 230                 235                 240 
Leu Asn Glu Asp Glu Glu Trp Lys Cys Asp Gln Asp Met Asp Glu Asp
                245                 250                 255     
Asp Gly Arg Asp Ala Ala Pro Pro Gly Arg Leu Pro Gln Lys Leu Leu
            260                 265                 270         
Leu Glu Thr Ala Ala Pro Arg Val Ser Ser Ser Arg Arg Tyr Ser Glu
        275                 280                 285             
Gly Arg Glu Phe Arg Tyr Gly Ser Trp Arg Glu Pro Val Asn Pro Tyr
    290                 295                 300                 
Tyr Val Asn Ala Gly Tyr Ala Leu Ala Pro Ala Thr Ser Ala Asn Asp
305                 310                 315                 320 
Ser Glu Gln Gln Ser Leu Ser Ser Asp Ala Asp Thr Leu Ser Leu Thr
                325                 330                 335     
Asp Ser Ser Val Asp Gly Ile Pro Pro Tyr Arg Ile Arg Lys Gln His
            340                 345                 350         
Arg Arg Glu Met Gln Glu Ser Val Gln Val Asn Gly Arg Val Pro Leu
        355                 360                 365             
Pro His Ile Pro Arg Thr Tyr Arg Val Pro Lys Glu Val Arg Val Glu
    370                 375                 380                 
Pro Gln Lys Phe Ala Glu Glu Leu Ile His Arg Leu Glu Ala Val Gln
385                 390                 395                 400 
Arg Thr Arg Glu Ala Glu Glu Lys Leu Glu Glu Arg Leu Lys Arg Val
                405                 410                 415     
Arg Met Glu Glu Glu Gly Glu Asp Gly Asp Pro Ser Ser Gly Pro Pro
            420                 425                 430         
Gly Pro Cys His Lys Leu Pro Pro Ala Pro Ala Trp His His Phe Pro
        435                 440                 445             
Pro Arg Cys Val Asp Met Gly Cys Ala Gly Leu Arg Asp Ala His Glu
    450                 455                 460                 
Glu Asn Pro Glu Ser Ile Leu Asp Glu His Val Gln Arg Val Leu Arg
465                 470                 475                 480 
Thr Pro Gly Arg Gln Ser Pro Gly Pro Gly His Arg Ser Pro Asp Ser
                485                 490                 495     
Gly His Val Ala Lys Met Pro Val Ala Leu Gly Gly Ala Ala Ser Gly
            500                 505                 510         
His Gly Lys His Val Pro Lys Ser Gly Ala Lys Leu Asp Ala Ala Gly
        515                 520                 525             
Leu His His His Arg His Val His His His Val His His Ser Thr Ala
    530                 535                 540                 
Arg Pro Lys Glu Gln Val Glu Ala Glu Ala Thr Arg Arg Ala Gln Ser
545                 550                 555                 560 
Ser Phe Ala Trp Gly Leu Glu Pro His Ser His Gly Ala Arg Ser Arg
                565                 570                 575     
Gly Tyr Ser Glu Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu
            580                 585                 590         
Ala His Ser Gly Lys Val Gly Val Ala Cys Lys Arg Asn Ala Lys Lys
        595                 600                 605             
Ala Glu Ser Gly Lys Ser Ala Ser Thr Glu Val Pro Gly Ala Ser Glu
    610                 615                 620                 
Asp Ala Glu Lys Asn Gln Lys Ile Met Gln Trp Ile Ile Glu Gly Glu
625                 630                 635                 640 
Lys Glu Ile Ser Arg His Arg Arg Thr Gly His Gly Ser Ser Gly Thr
                645                 650                 655     
Arg Lys Pro Gln Pro His Glu Asn Ser Arg Pro Leu Ser Leu Glu His
            660                 665                 670         
Pro Trp Ala Gly Pro Gln Leu Arg Thr Ser Val Gln Pro Ser His Leu
        675                 680                 685             
Phe Ile Gln Asp Pro Thr Met Pro Pro His Pro Ala Pro Asn Pro Leu
    690                 695                 700                 
Thr Gln Leu Glu Glu Ala Arg Arg Arg Leu Glu Glu Glu Glu Lys Arg
705                 710                 715                 720 
Ala Ser Arg Ala Pro Ser Lys Gln Arg Thr Arg Ser Gln Arg Lys Val
                725                 730                 735     
Gly Gly Gly Ser Ala Gln Pro Cys Asp Ser Ile Val Val Ala Tyr Tyr
            740                 745                 750         
Phe Cys Gly Glu Pro Ile Pro Tyr Arg Thr Leu Val Arg Gly Arg Ala
        755                 760                 765             
Val Thr Leu Gly Gln Phe Lys Glu Leu Leu Thr Lys Lys Gly Ser Tyr
    770                 775                 780                 
Arg Tyr Tyr Phe Lys Lys Val Ser Asp Glu Phe Asp Cys Gly Val Val
785                 790                 795                 800 
Phe Glu Glu Val Arg Glu Asp Glu Ala Val Leu Pro Val Phe Glu Glu
                805                 810                 815     
Lys Ile Ile Gly Lys Val Glu Lys Val Asp
            820                 825     


<210> 7069
<211> 862
<212> PRT
<213> Homo sapiens

<400> 7069
Met Asn Ile Gln Glu Gln Gly Phe Pro Leu Asp Leu Gly Ala Ser Phe
 1               5                  10                  15      
Thr Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu Leu
            20                  25                  30          
Val Ser Thr Asp Pro Arg Pro Ala Ser Tyr Ser Phe Cys Ser Gly Lys
        35                  40                  45              
Gly Val Gly Ile Lys Gly Glu Thr Ser Thr Ala Thr Pro Arg Arg Ser
    50                  55                  60                  
Asp Leu Asp Leu Gly Tyr Glu Pro Glu Gly Ser Ala Ser Pro Thr Pro
65                  70                  75                  80  
Pro Tyr Leu Lys Trp Ala Glu Ser Leu His Ser Leu Leu Asp Asp Gln
                85                  90                  95      
Asp Gly Ile Ser Leu Phe Arg Thr Phe Leu Lys Gln Glu Gly Cys Ala
            100                 105                 110         
Asp Leu Leu Asp Phe Trp Phe Ala Cys Thr Gly Phe Arg Lys Leu Glu
        115                 120                 125             
Pro Cys Asp Ser Asn Glu Glu Lys Arg Leu Lys Leu Ala Arg Ala Ile
    130                 135                 140                 
Tyr Arg Lys Tyr Ile Leu Asp Asn Asn Gly Ile Val Ser Arg Gln Thr
145                 150                 155                 160 
Lys Pro Ala Thr Lys Ser Phe Ile Lys Gly Cys Ile Met Lys Gln Leu
                165                 170                 175     
Ile Asp Pro Ala Met Phe Asp Gln Ala Gln Thr Glu Ile Gln Ala Thr
            180                 185                 190         
Met Glu Glu Asn Thr Tyr Pro Ser Phe Leu Lys Ser Asp Ile Tyr Leu
        195                 200                 205             
Glu Tyr Thr Arg Thr Gly Ser Glu Ser Pro Lys Val Cys Ser Asp Gln
    210                 215                 220                 
Ser Ser Gly Ser Gly Thr Gly Lys Gly Ile Ser Gly Tyr Leu Pro Thr
225                 230                 235                 240 
Leu Asn Glu Asp Glu Glu Trp Lys Cys Asp Gln Asp Met Asp Glu Asp
                245                 250                 255     
Asp Gly Arg Asp Ala Ala Pro Pro Gly Arg Leu Pro Gln Lys Leu Leu
            260                 265                 270         
Leu Glu Thr Ala Ala Pro Arg Val Ser Ser Ser Arg Arg Tyr Ser Glu
        275                 280                 285             
Gly Arg Glu Phe Arg Tyr Gly Ser Trp Arg Glu Pro Val Asn Pro Tyr
    290                 295                 300                 
Tyr Val Asn Ala Gly Tyr Ala Leu Ala Pro Ala Thr Ser Ala Asn Asp
305                 310                 315                 320 
Ser Glu Gln Gln Ser Leu Ser Ser Asp Ala Asp Thr Leu Ser Leu Thr
                325                 330                 335     
Asp Ser Ser Val Asp Gly Ile Pro Pro Tyr Arg Ile Arg Lys Gln His
            340                 345                 350         
Arg Arg Glu Met Gln Glu Ser Val Gln Val Asn Gly Arg Val Pro Leu
        355                 360                 365             
Pro His Ile Pro Arg Thr Tyr Arg Val Pro Lys Glu Val Arg Val Glu
    370                 375                 380                 
Pro Gln Lys Phe Ala Glu Glu Leu Ile His Arg Leu Glu Ala Val Gln
385                 390                 395                 400 
Arg Thr Arg Glu Ala Glu Glu Lys Leu Glu Glu Arg Leu Lys Arg Val
                405                 410                 415     
Arg Met Glu Glu Glu Gly Glu Asp Gly Asp Pro Ser Ser Gly Pro Pro
            420                 425                 430         
Gly Pro Cys His Lys Leu Pro Pro Ala Pro Ala Trp His His Phe Pro
        435                 440                 445             
Pro Arg Cys Val Asp Met Gly Cys Ala Gly Leu Arg Asp Ala His Glu
    450                 455                 460                 
Glu Asn Pro Glu Ser Ile Leu Asp Glu His Val Gln Arg Val Leu Arg
465                 470                 475                 480 
Thr Pro Gly Arg Gln Ser Pro Gly Pro Gly His Arg Ser Pro Asp Ser
                485                 490                 495     
Gly His Val Ala Lys Met Pro Val Ala Leu Gly Gly Ala Ala Ser Gly
            500                 505                 510         
His Gly Lys His Val Pro Lys Ser Gly Ala Lys Leu Asp Ala Ala Gly
        515                 520                 525             
Leu His His His Arg His Val His His His Val His His Ser Thr Ala
    530                 535                 540                 
Arg Pro Lys Glu Gln Val Glu Ala Glu Ala Thr Arg Arg Ala Gln Ser
545                 550                 555                 560 
Ser Phe Ala Trp Gly Leu Glu Pro His Ser His Gly Ala Arg Ser Arg
                565                 570                 575     
Gly Tyr Ser Glu Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu
            580                 585                 590         
Ala His Ser Gly Lys Val Gly Val Ala Cys Lys Arg Asn Ala Lys Lys
        595                 600                 605             
Ala Glu Ser Gly Lys Ser Ala Ser Thr Glu Val Pro Gly Ala Ser Glu
    610                 615                 620                 
Asp Ala Glu Lys Asn Gln Lys Ile Met Gln Trp Ile Ile Glu Gly Glu
625                 630                 635                 640 
Lys Glu Ile Ser Arg His Arg Arg Thr Gly His Gly Ser Ser Gly Thr
                645                 650                 655     
Arg Lys Pro Gln Pro His Glu Asn Ser Arg Pro Leu Ser Leu Glu His
            660                 665                 670         
Pro Trp Ala Gly Pro Gln Leu Arg Thr Ser Val Gln Pro Ser His Leu
        675                 680                 685             
Phe Ile Gln Asp Pro Thr Met Pro Pro His Pro Ala Pro Asn Pro Leu
    690                 695                 700                 
Thr Gln Leu Glu Glu Ala Arg Arg Arg Leu Glu Glu Glu Glu Lys Arg
705                 710                 715                 720 
Ala Ser Arg Ala Pro Ser Lys Gln Arg Tyr Val Gln Glu Val Met Arg
                725                 730                 735     
Arg Gly Arg Ala Cys Val Arg Pro Ala Cys Ala Pro Val Leu His Val
            740                 745                 750         
Val Pro Ala Val Ser Asp Met Glu Leu Ser Glu Thr Glu Thr Arg Ser
        755                 760                 765             
Gln Arg Lys Val Gly Gly Gly Ser Ala Gln Pro Cys Asp Ser Ile Val
    770                 775                 780                 
Val Ala Tyr Tyr Phe Cys Gly Glu Pro Ile Pro Tyr Arg Thr Leu Val
785                 790                 795                 800 
Arg Gly Arg Ala Val Thr Leu Gly Gln Phe Lys Glu Leu Leu Thr Lys
                805                 810                 815     
Lys Gly Ser Tyr Arg Tyr Tyr Phe Lys Lys Val Ser Asp Glu Phe Asp
            820                 825                 830         
Cys Gly Val Val Phe Glu Glu Val Arg Glu Asp Glu Ala Val Leu Pro
        835                 840                 845             
Val Phe Glu Glu Lys Ile Ile Gly Lys Val Glu Lys Val Asp
    850                 855                 860         


<210> 7070
<211> 131
<212> PRT
<213> Homo sapiens

<400> 7070
Met Ala Pro Glu Glu Asn Ala Gly Ser Glu Leu Leu Leu Gln Ser Phe
 1               5                  10                  15      
Lys Arg Arg Phe Leu Ala Ala Arg Ala Leu Arg Ser Phe Arg Trp Gln
            20                  25                  30          
Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu Leu Leu Arg
        35                  40                  45              
Asp Ile Leu Gln Lys Thr Cys Cys Ile Ala Gln Lys Pro Ser Cys Arg
    50                  55                  60                  
Trp Ser Gly Ser Cys Gly Gly Trp Leu Pro Ala Gly Ser Thr Ser Gly
65                  70                  75                  80  
Leu Leu Asn Ser Thr Trp Pro Leu Pro Ser Ala Thr Gln Arg Cys Ala
                85                  90                  95      
Ser Cys Ser Pro Pro Ser Tyr Ala Gly Leu Gly Ser Asp Gly Lys Arg
            100                 105                 110         
Lys Leu Ile Met Thr Arg Asn Cys Phe Pro Thr Glu Ser Thr Trp Arg
        115                 120                 125             
Trp Gln Ser
    130     


<210> 7071
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7071
Met Ala Pro Glu Glu Asn Ser Gly Ser Glu Leu Leu Leu Gln Ser Phe
 1               5                  10                  15      
Lys Arg Arg Phe Leu Ala Ala Arg Ala Leu Arg Ser Phe Pro Trp Gln
            20                  25                  30          
Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu Leu Leu Arg
        35                  40                  45              
Asp Ile Leu Gln Lys His Glu Ala Val His Thr Glu Pro Leu Asp Glu
    50                  55                  60                  
Leu Tyr Glu Val Leu Ala Glu Thr Leu Met Ala Lys Glu Ser Thr Gln
65                  70                  75                  80  
Gly His Arg Ser Tyr Leu Leu Thr Cys Cys Ile Ala Gln Lys Pro Ser
                85                  90                  95      
Cys Arg Trp Ser Gly Ser Cys Gly Gly Trp Leu Pro Ala Gly Ser Thr
            100                 105                 110         
Ser Gly Leu Leu Asn Ser Thr Trp Pro Leu Pro Ser Ala Thr Gln Arg
        115                 120                 125             
Cys Ala Ser Cys Ser Pro Pro Ser Tyr Ala Gly Leu Gly Ser Asp Gly
    130                 135                 140                 
Lys Arg Lys Leu Ile Met Thr Arg Asn Cys Phe Pro Thr Glu Ser Thr
145                 150                 155                 160 
Trp Arg Trp Gln Ser
                165 


<210> 7072
<211> 3664
<212> PRT
<213> Homo sapiens

<400> 7072
Met Val Arg Glu Thr Arg His Leu Trp Val Gly Asn Leu Pro Glu Asn
 1               5                  10                  15      
Val Arg Glu Glu Lys Ile Ile Glu His Phe Lys Arg Tyr Gly Arg Val
            20                  25                  30          
Glu Ser Val Lys Ile Leu Pro Lys Arg Gly Ser Glu Gly Gly Val Ala
        35                  40                  45              
Ala Phe Val Asp Phe Val Asp Ile Lys Ser Ala Gln Lys Ala His Asn
    50                  55                  60                  
Ser Val Asn Lys Met Gly Asp Arg Asp Leu Arg Thr Asp Tyr Asn Glu
65                  70                  75                  80  
Pro Gly Thr Ile Pro Ser Ala Ala Arg Gly Leu Asp Asp Thr Val Ser
                85                  90                  95      
Ile Ala Ser Arg Ser Arg Glu Val Ser Gly Phe Arg Gly Gly Gly Gly
            100                 105                 110         
Gly Pro Ala Tyr Gly Pro Pro Pro Ser Leu His Ala Arg Glu Gly Arg
        115                 120                 125             
Tyr Glu Arg Arg Leu Asp Gly Ala Ser Asp Asn Arg Glu Arg Ala Tyr
    130                 135                 140                 
Glu His Ser Ala Tyr Gly His His Glu Arg Gly Thr Gly Gly Phe Asp
145                 150                 155                 160 
Arg Thr Arg His Tyr Asp Gln Asp Tyr Tyr Arg Asp Pro Arg Glu Arg
                165                 170                 175     
Thr Leu Gln His Gly Leu Tyr Tyr Ala Ser Arg Ser Arg Ser Pro Asn
            180                 185                 190         
Arg Phe Asp Ala His Asp Pro Arg Tyr Glu Pro Arg Ala Arg Glu Gln
        195                 200                 205             
Phe Thr Leu Pro Ser Val Val His Arg Asp Ile Tyr Arg Asp Asp Ile
    210                 215                 220                 
Thr Arg Glu Val Arg Gly Arg Arg Pro Glu Arg Asn Tyr Gln His Ser
225                 230                 235                 240 
Arg Ser Arg Ser Pro His Ser Ser Gln Ser Arg Asn Gln Ser Pro Gln
                245                 250                 255     
Arg Leu Ala Ser Gln Ala Ser Arg Pro Thr Arg Ser Pro Ser Gly Ser
            260                 265                 270         
Gly Ser Arg Ser Arg Ser Ser Ser Ser Asp Ser Ile Ser Ser Ser Ser
        275                 280                 285             
Ser Thr Ser Ser Asp Ser Ser Asp Ser Ser Ser Ser Ser Ser Asp Asp
    290                 295                 300                 
Ser Pro Ala Arg Ser Val Gln Ser Ala Ala Val Pro Ala Pro Thr Ser
305                 310                 315                 320 
Gln Leu Leu Ser Ser Leu Glu Lys Asp Glu Pro Arg Lys Ser Phe Gly
                325                 330                 335     
Ile Lys Val Gln Asn Leu Pro Val Arg Ser Thr Asp Thr Ser Leu Lys
            340                 345                 350         
Asp Gly Leu Phe His Glu Phe Lys Lys Phe Gly Lys Val Thr Ser Val
        355                 360                 365             
Gln Ile His Gly Thr Ser Glu Glu Arg Tyr Gly Leu Val Phe Phe Arg
    370                 375                 380                 
Gln Gln Glu Asp Gln Glu Lys Ala Leu Thr Ala Ser Lys Gly Lys Leu
385                 390                 395                 400 
Phe Phe Gly Met Gln Ile Glu Val Thr Ala Trp Ile Gly Pro Glu Thr
                405                 410                 415     
Glu Ser Glu Asn Glu Phe Arg Pro Leu Asp Glu Arg Ile Asp Glu Phe
            420                 425                 430         
His Pro Lys Ala Thr Arg Thr Leu Phe Ile Gly Asn Leu Glu Lys Thr
        435                 440                 445             
Thr Thr Tyr His Asp Leu Arg Asn Ile Phe Gln Arg Phe Gly Glu Ile
    450                 455                 460                 
Val Asp Ile Asp Ile Lys Lys Val Asn Gly Val Pro Gln Tyr Ala Phe
465                 470                 475                 480 
Leu Gln Tyr Cys Asp Ile Ala Ser Val Cys Lys Ala Ile Lys Lys Met
                485                 490                 495     
Asp Gly Glu Tyr Leu Gly Asn Asn Arg Leu Lys Leu Gly Phe Gly Lys
            500                 505                 510         
Ser Met Pro Thr Asn Cys Val Trp Leu Asp Gly Leu Ser Ser Asn Val
        515                 520                 525             
Ser Asp Gln Tyr Leu Thr Arg His Phe Cys Arg Tyr Gly Pro Val Val
    530                 535                 540                 
Lys Val Val Phe Asp Arg Leu Lys Gly Met Ala Leu Val Leu Tyr Asn
545                 550                 555                 560 
Glu Ile Glu Tyr Ala Gln Ala Ala Val Lys Glu Thr Lys Gly Arg Lys
                565                 570                 575     
Ile Gly Gly Asn Lys Ile Lys Val Asp Phe Ala Asn Arg Glu Ser Gln
            580                 585                 590         
Leu Ala Phe Tyr His Cys Met Glu Lys Ser Gly Gln Asp Ile Arg Asp
        595                 600                 605             
Phe Tyr Glu Met Leu Ala Glu Arg Arg Glu Glu Arg Arg Ala Ser Tyr
    610                 615                 620                 
Asp Tyr Asn Gln Asp Arg Thr Tyr Tyr Glu Ser Val Arg Thr Pro Gly
625                 630                 635                 640 
Thr Tyr Pro Glu Asp Ser Arg Arg Asp Tyr Pro Ala Arg Gly Arg Glu
                645                 650                 655     
Phe Tyr Ser Glu Trp Glu Thr Tyr Gln Gly Asp Tyr Tyr Glu Ser Arg
            660                 665                 670         
Tyr Tyr Asp Asp Pro Arg Glu Tyr Arg Asp Tyr Arg Asn Asp Pro Tyr
        675                 680                 685             
Glu Gln Asp Ile Arg Glu Tyr Ser Tyr Arg Gln Arg Glu Arg Glu Arg
    690                 695                 700                 
Glu Arg Glu Arg Phe Glu Ser Asp Arg Asp Arg Asp His Glu Arg Arg
705                 710                 715                 720 
Pro Ile Glu Arg Ser Gln Ser Pro Val His Leu Arg Arg Pro Gln Ser
                725                 730                 735     
Pro Gly Ala Ser Pro Ser Gln Ala Glu Arg Leu Pro Ser Asp Ser Glu
            740                 745                 750         
Arg Arg Leu Tyr Ser Arg Ser Ser Asp Arg Ser Gly Ser Cys Ser Ser
        755                 760                 765             
Leu Ser Pro Pro Arg Tyr Glu Lys Leu Asp Lys Ser Arg Leu Glu Arg
    770                 775                 780                 
Tyr Thr Lys Asn Glu Lys Thr Asp Lys Glu Arg Thr Phe Asp Pro Glu
785                 790                 795                 800 
Arg Val Glu Arg Glu Arg Arg Leu Ile Arg Lys Glu Lys Val Glu Lys
                805                 810                 815     
Asp Lys Thr Asp Lys Gln Lys Arg Lys Gly Lys Val His Ser Pro Ser
            820                 825                 830         
Ser Gln Ser Ser Glu Thr Asp Gln Glu Asn Glu Arg Glu Gln Ser Pro
        835                 840                 845             
Glu Lys Pro Arg Ser Cys Asn Lys Leu Ser Arg Glu Lys Ala Asp Lys
    850                 855                 860                 
Glu Gly Ile Ala Lys Asn Arg Leu Glu Leu Met Pro Cys Val Val Leu
865                 870                 875                 880 
Thr Arg Val Lys Glu Lys Glu Gly Lys Val Ile Asp His Thr Pro Val
                885                 890                 895     
Glu Lys Leu Lys Ala Lys Leu Asp Asn Asp Thr Val Lys Ser Ser Ala
            900                 905                 910         
Leu Asp Gln Lys Leu Gln Val Ser Gln Thr Glu Pro Ala Lys Ser Asp
        915                 920                 925             
Leu Ser Lys Leu Glu Ser Val Arg Met Lys Val Pro Lys Glu Lys Gly
    930                 935                 940                 
Leu Ser Ser His Val Glu Val Val Glu Lys Glu Gly Arg Leu Lys Ala
945                 950                 955                 960 
Arg Lys His Leu Lys Pro Glu Gln Pro Ala Asp Gly Val Ser Ala Val
                965                 970                 975     
Asp Leu Glu Lys Leu Glu Ala Arg Lys Arg Arg Phe Ala Asp Ser Asn
            980                 985                 990         
Leu Lys Ala Glu Lys Gln Lys Pro Glu Val Lys Lys Ser Ser Pro Glu
        995                 1000                1005            
Met Glu Asp Ala Arg Val Leu Ser Lys Lys Gln Pro Asp Val Ser Ser
    1010                1015                1020                
Arg Glu Val Ile Leu Leu Arg Glu Gly Glu Ala Glu Arg Lys Pro Val
1025                1030                1035                1040
Arg Lys Glu Ile Leu Lys Arg Glu Ser Lys Lys Ile Lys Leu Asp Arg
                1045                1050                1055    
Leu Asn Thr Val Ala Ser Pro Lys Asp Cys Gln Glu Leu Ala Ser Ile
            1060                1065                1070        
Ser Val Gly Ser Gly Ser Arg Pro Ser Ser Asp Leu Gln Ala Arg Leu
        1075                1080                1085            
Gly Glu Leu Ala Gly Glu Ser Val Glu Asn Gln Glu Val Gln Ser Lys
    1090                1095                1100                
Lys Pro Ile Pro Ser Lys Pro Gln Leu Lys Gln Leu Gln Val Leu Asp
1105                1110                1115                1120
Asp Gln Gly Pro Glu Arg Glu Asp Val Arg Lys Asn Tyr Cys Ser Leu
                1125                1130                1135    
Arg Asp Glu Thr Pro Glu Arg Lys Ser Gly Gln Glu Lys Ser His Ser
            1140                1145                1150        
Val Asn Thr Glu Glu Lys Ile Gly Ile Asp Ile Asp His Thr Gln Ser
        1155                1160                1165            
Tyr Arg Lys Gln Met Glu Gln Ser Arg Arg Lys Gln Gln Met Glu Met
    1170                1175                1180                
Glu Ile Ala Lys Ser Glu Lys Phe Gly Ser Pro Lys Lys Asp Val Asp
1185                1190                1195                1200
Glu Tyr Glu Arg Arg Ser Leu Val His Glu Val Gly Lys Pro Pro Gln
                1205                1210                1215    
Asp Val Thr Asp Asp Ser Pro Pro Ser Lys Lys Lys Arg Met Asp His
            1220                1225                1230        
Val Asp Phe Asp Ile Cys Thr Lys Arg Glu Arg Asn Tyr Arg Ser Ser
        1235                1240                1245            
Arg Gln Ile Ser Glu Asp Ser Glu Arg Thr Gly Gly Ser Pro Ser Val
    1250                1255                1260                
Arg His Gly Ser Phe His Glu Asp Glu Asp Pro Ile Gly Ser Pro Arg
1265                1270                1275                1280
Leu Leu Ser Val Lys Gly Ser Pro Lys Val Asp Glu Lys Val Leu Pro
                1285                1290                1295    
Tyr Ser Asn Ile Thr Val Arg Glu Glu Ser Leu Lys Phe Asn Pro Tyr
            1300                1305                1310        
Asp Ser Ser Arg Arg Glu Gln Met Ala Asp Met Ala Lys Ile Lys Leu
        1315                1320                1325            
Ser Val Leu Asn Ser Glu Asp Glu Leu Asn Arg Trp Asp Ser Gln Met
    1330                1335                1340                
Lys Gln Asp Ala Gly Arg Phe Asp Val Ser Phe Pro Asn Ser Ile Ile
1345                1350                1355                1360
Lys Arg Asp Ser Leu Arg Lys Arg Ser Val Arg Asp Leu Glu Pro Gly
                1365                1370                1375    
Glu Val Pro Ser Asp Ser Asp Glu Asp Gly Glu His Lys Ser His Ser
            1380                1385                1390        
Pro Arg Ala Ser Ala Leu Tyr Glu Ser Ser Arg Leu Ser Phe Leu Leu
        1395                1400                1405            
Arg Asp Arg Glu Asp Lys Leu Arg Glu Arg Asp Glu Arg Leu Ser Ser
    1410                1415                1420                
Ser Leu Glu Arg Asn Lys Phe Tyr Ser Phe Ala Leu Asp Lys Thr Ile
1425                1430                1435                1440
Thr Pro Asp Thr Lys Ala Leu Leu Glu Arg Ala Lys Ser Leu Ser Ser
                1445                1450                1455    
Ser Arg Glu Glu Asn Trp Ser Phe Leu Asp Trp Asp Ser Arg Phe Ala
            1460                1465                1470        
Asn Phe Arg Asn Asn Lys Asp Lys Glu Lys Val Asp Ser Ala Pro Arg
        1475                1480                1485            
Pro Ile Pro Ser Trp Tyr Met Lys Lys Lys Lys Ile Arg Thr Asp Ser
    1490                1495                1500                
Glu Gly Lys Met Asp Asp Lys Lys Glu Asp His Lys Glu Glu Glu Gln
1505                1510                1515                1520
Glu Arg Gln Glu Leu Phe Ala Ser Arg Phe Leu His Ser Ser Ile Phe
                1525                1530                1535    
Glu Gln Asp Ser Lys Arg Leu Gln His Leu Glu Arg Lys Glu Glu Asp
            1540                1545                1550        
Ser Asp Phe Ile Ser Gly Arg Ile Tyr Gly Lys Gln Thr Ser Glu Gly
        1555                1560                1565            
Ala Asn Ser Thr Thr Asp Ser Ile Gln Glu Pro Val Val Leu Phe His
    1570                1575                1580                
Ser Arg Phe Met Glu Leu Thr Arg Met Gln Gln Lys Glu Lys Glu Lys
1585                1590                1595                1600
Asp Gln Lys Pro Lys Glu Val Glu Lys Gln Glu Asp Thr Glu Asn His
                1605                1610                1615    
Pro Lys Thr Pro Glu Ser Ala Pro Glu Asn Lys Asp Ser Glu Leu Lys
            1620                1625                1630        
Thr Pro Pro Ser Val Gly Pro Pro Ser Val Thr Val Val Thr Leu Glu
        1635                1640                1645            
Ser Ala Pro Ser Ala Leu Glu Lys Thr Thr Gly Asp Lys Thr Val Glu
    1650                1655                1660                
Ala Pro Leu Val Thr Glu Glu Lys Thr Val Glu Pro Ala Thr Val Ser
1665                1670                1675                1680
Glu Glu Ala Lys Pro Ala Ser Glu Pro Ala Pro Ala Pro Val Glu Gln
                1685                1690                1695    
Leu Glu Gln Val Asp Leu Pro Pro Gly Ala Asp Pro Asp Lys Glu Ala
            1700                1705                1710        
Ala Met Met Pro Ala Gly Val Glu Glu Gly Ser Ser Gly Asp Gln Pro
        1715                1720                1725            
Pro Tyr Leu Asp Ala Lys Pro Pro Thr Pro Gly Ala Ser Phe Ser Gln
    1730                1735                1740                
Ala Glu Ser Asn Val Asp Pro Glu Pro Asp Ser Thr Gln Pro Leu Ser
1745                1750                1755                1760
Lys Pro Ala Gln Lys Ser Glu Glu Ala Asn Glu Pro Lys Ala Glu Lys
                1765                1770                1775    
Pro Asp Ala Thr Ala Asp Ala Glu Pro Asp Ala Asn Gln Lys Ala Glu
            1780                1785                1790        
Ala Ala Pro Glu Ser Gln Pro Pro Ala Ser Glu Asp Leu Glu Val Asp
        1795                1800                1805            
Pro Pro Val Ala Ala Lys Asp Lys Lys Pro Asn Lys Ser Lys Arg Ser
    1810                1815                1820                
Lys Thr Pro Val Gln Ala Ala Ala Val Ser Ile Val Glu Lys Pro Val
1825                1830                1835                1840
Thr Arg Lys Ser Glu Arg Ile Asp Arg Glu Lys Leu Lys Arg Ser Asn
                1845                1850                1855    
Ser Pro Arg Gly Glu Ala Gln Lys Leu Leu Glu Leu Lys Met Glu Ala
            1860                1865                1870        
Glu Lys Ile Thr Arg Thr Ala Ser Lys Asn Ser Ala Ala Asp Leu Glu
        1875                1880                1885            
His Pro Glu Pro Ser Leu Pro Leu Ser Arg Thr Arg Arg Arg Asn Val
    1890                1895                1900                
Arg Ser Val Tyr Ala Thr Met Gly Asp His Glu Asn Arg Ser Pro Val
1905                1910                1915                1920
Lys Glu Pro Val Glu Gln Pro Arg Val Thr Arg Lys Arg Leu Glu Arg
                1925                1930                1935    
Glu Leu Gln Glu Ala Ala Ala Val Pro Thr Thr Pro Arg Arg Gly Arg
            1940                1945                1950        
Pro Pro Lys Thr Arg Arg Arg Ala Asp Glu Glu Glu Glu Asn Glu Ala
        1955                1960                1965            
Lys Glu Pro Ala Glu Thr Leu Lys Pro Pro Glu Gly Trp Arg Ser Pro
    1970                1975                1980                
Arg Ser Gln Lys Thr Ala Ala Gly Gly Gly Pro Gln Gly Lys Lys Gly
1985                1990                1995                2000
Lys Asn Glu Pro Lys Val Asp Ala Thr Arg Pro Glu Ala Thr Thr Glu
                2005                2010                2015    
Val Gly Pro Gln Ile Gly Val Lys Glu Ser Ser Met Glu Pro Lys Ala
            2020                2025                2030        
Ala Glu Glu Glu Ala Gly Ser Glu Gln Lys Arg Asp Arg Lys Asp Ala
        2035                2040                2045            
Gly Thr Asp Lys Asn Pro Pro Glu Thr Ala Pro Val Glu Val Val Glu
    2050                2055                2060                
Lys Lys Pro Ala Pro Glu Lys Asn Ser Lys Ser Lys Arg Gly Arg Ser
2065                2070                2075                2080
Arg Asn Ser Arg Leu Ala Val Asp Lys Ser Ala Ser Leu Lys Asn Val
                2085                2090                2095    
Asp Ala Ala Val Ser Pro Arg Gly Ala Ala Ala Gln Ala Gly Glu Arg
            2100                2105                2110        
Glu Ser Gly Val Val Ala Val Ser Pro Glu Lys Ser Glu Ser Pro Gln
        2115                2120                2125            
Lys Glu Asp Gly Leu Ser Ser Gln Leu Lys Ser Asp Pro Val Asp Pro
    2130                2135                2140                
Asp Lys Glu Pro Glu Lys Glu Asp Val Ser Ala Ser Gly Pro Ser Pro
2145                2150                2155                2160
Glu Ala Thr Gln Leu Ala Lys Gln Met Glu Leu Glu Gln Ala Val Glu
                2165                2170                2175    
His Ile Ala Lys Leu Ala Glu Ala Ser Ala Ser Ala Ala Tyr Lys Ala
            2180                2185                2190        
Asp Ala Pro Glu Gly Leu Ala Pro Glu Asp Arg Asp Lys Pro Ala His
        2195                2200                2205            
Gln Ala Ser Glu Thr Glu Leu Ala Ala Ala Ile Gly Ser Ile Ile Asn
    2210                2215                2220                
Asp Ile Ser Gly Glu Pro Glu Asn Phe Pro Ala Pro Pro Pro Tyr Pro
2225                2230                2235                2240
Gly Glu Ser Gln Thr Asp Leu Gln Pro Pro Ala Gly Ala Gln Ala Leu
                2245                2250                2255    
Gln Pro Ser Glu Glu Gly Met Glu Thr Asp Glu Ala Val Ser Gly Ile
            2260                2265                2270        
Leu Glu Thr Glu Ala Ala Thr Glu Ser Ser Arg Pro Pro Val Asn Ala
        2275                2280                2285            
Pro Asp Pro Ser Ala Gly Pro Thr Asp Thr Lys Glu Ala Arg Gly Asn
    2290                2295                2300                
Ser Ser Glu Thr Ser His Ser Val Pro Glu Ala Lys Gly Ser Lys Glu
2305                2310                2315                2320
Val Glu Val Thr Leu Val Arg Lys Asp Lys Gly Arg Gln Lys Thr Thr
                2325                2330                2335    
Arg Ser Arg Arg Lys Arg Asn Thr Asn Lys Lys Val Val Ala Pro Val
            2340                2345                2350        
Glu Ser His Val Pro Glu Ser Asn Gln Ala Gln Gly Glu Ser Pro Ala
        2355                2360                2365            
Ala Asn Glu Gly Thr Thr Val Gln His Pro Glu Ala Pro Gln Glu Glu
    2370                2375                2380                
Lys Gln Ser Glu Lys Pro His Ser Thr Pro Pro Gln Ser Cys Thr Ser
2385                2390                2395                2400
Asp Leu Ser Lys Ile Pro Ser Thr Glu Asn Ser Ser Gln Glu Ile Ser
                2405                2410                2415    
Val Glu Glu Arg Thr Pro Thr Lys Ala Ser Val Pro Pro Asp Leu Pro
            2420                2425                2430        
Pro Pro Pro Gln Pro Ala Pro Val Asp Glu Glu Pro Gln Ala Arg Phe
        2435                2440                2445            
Arg Val His Ser Ile Ile Glu Ser Asp Pro Val Thr Pro Pro Ser Asp
    2450                2455                2460                
Pro Ser Ile Pro Ile Pro Thr Leu Pro Ser Val Thr Ala Ala Lys Leu
2465                2470                2475                2480
Ser Pro Pro Val Ala Ser Gly Gly Ile Pro His Gln Ser Pro Pro Thr
                2485                2490                2495    
Lys Val Thr Glu Trp Ile Thr Arg Gln Glu Glu Pro Arg Ala Gln Ser
            2500                2505                2510        
Thr Pro Ser Pro Ala Leu Pro Pro Asp Thr Lys Ala Ser Asp Val Asp
        2515                2520                2525            
Thr Ser Ser Ser Thr Leu Arg Lys Ile Leu Met Asp Pro Lys Tyr Val
    2530                2535                2540                
Ser Ala Thr Ser Val Thr Ser Thr Ser Val Thr Thr Ala Ile Ala Glu
2545                2550                2555                2560
Pro Val Ser Ala Ala Pro Cys Leu His Glu Ala Pro Pro Pro Pro Val
                2565                2570                2575    
Asp Ser Lys Lys Pro Leu Glu Glu Lys Thr Ala Pro Pro Val Thr Asn
            2580                2585                2590        
Asn Ser Glu Ile Gln Ala Ser Glu Val Leu Val Ala Ala Asp Lys Glu
        2595                2600                2605            
Lys Val Ala Pro Val Ile Ala Pro Lys Ile Thr Ser Val Ile Ser Arg
    2610                2615                2620                
Met Pro Val Ser Ile Asp Leu Glu Asn Ser Gln Lys Ile Thr Leu Ala
2625                2630                2635                2640
Lys Pro Ala Pro Gln Thr Leu Thr Gly Leu Val Ser Ala Leu Thr Gly
                2645                2650                2655    
Leu Val Asn Val Ser Leu Val Pro Val Asn Ala Leu Lys Gly Pro Val
            2660                2665                2670        
Lys Gly Ser Val Thr Thr Leu Lys Ser Leu Val Ser Thr Pro Ala Gly
        2675                2680                2685            
Pro Val Asn Val Leu Lys Gly Pro Val Asn Val Leu Thr Gly Pro Val
    2690                2695                2700                
Asn Val Leu Thr Thr Pro Val Asn Ala Thr Val Gly Thr Val Asn Ala
2705                2710                2715                2720
Ala Pro Gly Thr Val Asn Ala Ala Ala Ser Ala Val Asn Ala Thr Ala
                2725                2730                2735    
Ser Ala Val Thr Val Thr Ala Gly Ala Val Thr Ala Ala Ser Gly Gly
            2740                2745                2750        
Val Thr Ala Thr Thr Gly Thr Val Thr Met Ala Gly Ala Val Ile Ala
        2755                2760                2765            
Pro Ser Thr Lys Cys Lys Gln Arg Ala Ser Ala Asn Glu Asn Ser Arg
    2770                2775                2780                
Phe His Pro Gly Ser Met Pro Val Ile Asp Asp Arg Pro Ala Asp Ala
2785                2790                2795                2800
Gly Ser Gly Ala Gly Leu Arg Val Asn Thr Ser Glu Gly Val Val Leu
                2805                2810                2815    
Leu Ser Tyr Ser Gly Gln Lys Thr Glu Gly Pro Gln Arg Ile Ser Ala
            2820                2825                2830        
Lys Ile Ser Gln Ile Pro Pro Ala Ser Ala Met Asp Ile Glu Phe Gln
        2835                2840                2845            
Gln Ser Val Ser Lys Ser Gln Val Lys Pro Asp Ser Val Thr Ala Ser
    2850                2855                2860                
Gln Pro Pro Ser Lys Gly Pro Gln Ala Pro Ala Gly Tyr Ala Asn Val
2865                2870                2875                2880
Ala Thr His Ser Thr Leu Val Leu Thr Ala Gln Thr Tyr Asn Ala Ser
                2885                2890                2895    
Pro Val Ile Ser Ser Val Lys Ala Asp Arg Pro Ser Leu Glu Lys Pro
            2900                2905                2910        
Glu Pro Ile His Leu Ser Val Ser Thr Pro Val Thr Gln Gly Gly Thr
        2915                2920                2925            
Val Lys Val Leu Thr Gln Gly Ile Asn Thr Pro Pro Val Leu Val His
    2930                2935                2940                
Asn Gln Leu Val Leu Thr Pro Ser Ile Val Thr Thr Asn Lys Lys Leu
2945                2950                2955                2960
Ala Asp Pro Val Thr Leu Lys Ile Glu Thr Lys Val Leu Gln Pro Ala
                2965                2970                2975    
Asn Leu Gly Ser Thr Leu Thr Pro His His Pro Pro Ala Leu Pro Ser
            2980                2985                2990        
Lys Leu Pro Thr Glu Val Asn His Val Pro Ser Gly Pro Ser Ile Pro
        2995                3000                3005            
Ala Asp Arg Thr Val Ser His Leu Ala Ala Ala Lys Leu Asp Ala His
    3010                3015                3020                
Ser Pro Arg Pro Ser Gly Pro Gly Pro Ser Ser Phe Pro Arg Ala Ser
3025                3030                3035                3040
His Pro Ser Ser Thr Ala Ser Thr Ala Leu Ser Thr Asn Ala Thr Val
                3045                3050                3055    
Met Leu Ala Ala Gly Ile Pro Val Pro Gln Phe Ile Ser Ser Ile His
            3060                3065                3070        
Pro Glu Gln Ser Val Ile Met Pro Pro His Ser Ile Thr Gln Thr Val
        3075                3080                3085            
Ser Leu Ser His Leu Ser Gln Gly Glu Val Arg Met Asn Thr Pro Thr
    3090                3095                3100                
Leu Pro Ser Ile Thr Tyr Ser Ile Arg Pro Glu Ala Leu His Ser Pro
3105                3110                3115                3120
Arg Ala Pro Leu Gln Pro Gln Gln Ile Glu Val Arg Ala Pro Gln Arg
                3125                3130                3135    
Ala Ser Thr Pro Gln Pro Ala Pro Ala Gly Val Pro Ala Leu Ala Ser
            3140                3145                3150        
Gln His Pro Pro Glu Glu Glu Val His Tyr His Leu Pro Val Ala Arg
        3155                3160                3165            
Ala Thr Ala Pro Val Gln Ser Glu Val Leu Val Met Gln Ser Glu Tyr
    3170                3175                3180                
Arg Leu His Pro Tyr Thr Val Pro Arg Asp Val Arg Ile Met Val His
3185                3190                3195                3200
Pro His Val Thr Ala Val Ser Glu Gln Pro Arg Ala Ala Asp Gly Val
                3205                3210                3215    
Val Lys Val Pro Pro Ala Ser Lys Ala Pro Gln Gln Pro Gly Lys Glu
            3220                3225                3230        
Ala Ala Lys Thr Pro Asp Ala Lys Ala Ala Pro Thr Pro Thr Pro Ala
        3235                3240                3245            
Pro Val Pro Val Pro Val Pro Leu Pro Ala Pro Ala Pro Ala Pro His
    3250                3255                3260                
Gly Glu Ala Arg Ile Leu Thr Val Thr Pro Ser Asn Gln Leu Gln Gly
3265                3270                3275                3280
Leu Pro Leu Thr Pro Pro Val Val Val Thr His Gly Val Gln Ile Val
                3285                3290                3295    
His Ser Ser Gly Glu Leu Phe Gln Glu Tyr Arg Tyr Gly Asp Ile Arg
            3300                3305                3310        
Thr Tyr His Pro Pro Ala Gln Leu Thr His Thr Gln Phe Pro Ala Ala
        3315                3320                3325            
Ser Ser Val Gly Leu Pro Ser Arg Thr Lys Thr Ala Ala Gln Gly Pro
    3330                3335                3340                
Pro Pro Glu Gly Glu Pro Leu Gln Pro Pro Gln Pro Val Gln Ser Thr
3345                3350                3355                3360
Gln Pro Ala Gln Pro Ala Pro Pro Cys Pro Pro Ser Gln Leu Gly Gln
                3365                3370                3375    
Pro Gly Gln Pro Pro Ser Ser Lys Met Pro Gln Val Ser Gln Glu Ala
            3380                3385                3390        
Lys Gly Thr Gln Thr Gly Val Glu Gln Pro Arg Leu Pro Ala Gly Pro
        3395                3400                3405            
Ala Asn Arg Pro Pro Glu Pro His Thr Gln Val Gln Arg Ala Gln Ala
    3410                3415                3420                
Glu Thr Gly Pro Thr Ser Phe Pro Ser Pro Val Ser Val Ser Met Lys
3425                3430                3435                3440
Pro Asp Leu Pro Val Ser Leu Pro Thr Gln Thr Ala Pro Lys Gln Pro
                3445                3450                3455    
Leu Phe Val Pro Thr Thr Ser Gly Pro Ser Thr Pro Pro Gly Leu Val
            3460                3465                3470        
Leu Pro His Thr Glu Phe Gln Pro Ala Pro Lys Gln Asp Ser Ser Pro
        3475                3480                3485            
His Leu Thr Ser Gln Arg Pro Val Asp Met Val Gln Leu Leu Lys Lys
    3490                3495                3500                
Tyr Pro Ile Val Trp Gln Gly Leu Leu Ala Leu Lys Asn Asp Thr Ala
3505                3510                3515                3520
Ala Val Gln Leu His Phe Val Ser Gly Asn Asn Val Leu Ala His Arg
                3525                3530                3535    
Ser Leu Pro Leu Ser Glu Gly Gly Pro Pro Leu Arg Ile Ala Gln Arg
            3540                3545                3550        
Met Arg Leu Glu Ala Thr Gln Leu Glu Gly Val Ala Arg Arg Met Thr
        3555                3560                3565            
Val Glu Thr Asp Tyr Cys Leu Leu Leu Ala Leu Pro Cys Gly Arg Asp
    3570                3575                3580                
Gln Glu Asp Val Val Ser Gln Thr Glu Ser Leu Lys Ala Ala Phe Ile
3585                3590                3595                3600
Thr Tyr Leu Gln Ala Lys Gln Ala Ala Gly Ile Ile Asn Val Pro Asn
                3605                3610                3615    
Pro Gly Ser Asn Gln Pro Ala Tyr Val Leu Gln Ile Phe Pro Pro Cys
            3620                3625                3630        
Glu Phe Ser Glu Ser His Leu Ser Arg Leu Ala Pro Asp Leu Leu Ala
        3635                3640                3645            
Ser Ile Ser Asn Ile Ser Pro His Leu Met Ile Val Ile Ala Ser Val
    3650                3655                3660                


<210> 7073
<211> 258
<212> PRT
<213> Homo sapiens

<400> 7073
Met Leu Val Leu Tyr Gly His Ser Thr Gln Asp Leu Pro Glu Thr Asn
 1               5                  10                  15      
Ala Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser
            20                  25                  30          
Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys
        35                  40                  45              
Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys
    50                  55                  60                  
Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu
65                  70                  75                  80  
Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val
                85                  90                  95      
Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile
            100                 105                 110         
Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln
        115                 120                 125             
Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro
    130                 135                 140                 
Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala
145                 150                 155                 160 
Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys
                165                 170                 175     
Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys
            180                 185                 190         
Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly
        195                 200                 205             
Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Leu His Gly Val Thr
    210                 215                 220                 
Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val
225                 230                 235                 240 
Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala
                245                 250                 255     
Ser Asn
        


<210> 7074
<211> 3224
<212> PRT
<213> Homo sapiens

<400> 7074
Met Arg Arg Ser Lys Ala Asp Val Glu Arg Tyr Ile Ala Ser Val Gln
 1               5                  10                  15      
Gly Ser Thr Pro Ser Pro Arg Gln Lys Ser Met Lys Gly Phe Tyr Phe
            20                  25                  30          
Ala Lys Leu Tyr Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr
        35                  40                  45              
Ile Cys Thr Tyr Ile Asn Val Gln Glu Arg Asp Pro Lys Ala His Arg
    50                  55                  60                  
Phe Leu Gly Leu Leu Tyr Glu Leu Glu Glu Asn Thr Asp Lys Ala Val
65                  70                  75                  80  
Glu Cys Tyr Arg Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu
                85                  90                  95      
Val Leu Lys Ile Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly
            100                 105                 110         
Arg Ala Lys Tyr Trp Leu Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser
        115                 120                 125             
Pro Ala Ile Tyr Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu
    130                 135                 140                 
Asp Gly Trp Asn Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val
145                 150                 155                 160 
Arg Pro Asp Asp Val His Val Asn Ile Arg Leu Val Glu Val Tyr Arg
                165                 170                 175     
Ser Thr Lys Arg Leu Lys Asp Ala Val Ala His Cys His Glu Ala Glu
            180                 185                 190         
Arg Asn Ile Ala Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val
        195                 200                 205             
Gln Thr Leu Lys Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp
    210                 215                 220                 
Lys Ser Asp Trp Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala
225                 230                 235                 240 
Asn Leu Met Leu Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg
                245                 250                 255     
Glu Leu Leu Gln Ser Phe Asp Ser Ala Leu Gln Ser Val Lys Ser Leu
            260                 265                 270         
Gly Gly Asn Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His
        275                 280                 285             
Phe Tyr Met His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Ser
    290                 295                 300                 
Ser Asn Val Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr
305                 310                 315                 320 
Leu Ile Ala Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly
                325                 330                 335     
Glu Ala Gly Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser
            340                 345                 350         
Gln Ser Gly His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe
        355                 360                 365             
Leu Lys Glu Ile Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala
    370                 375                 380                 
Leu Tyr Asp Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe
385                 390                 395                 400 
Leu Gly Ser Asp Asp Ile Gly Asn Ile Asp Val Arg Glu Pro Glu Leu
                405                 410                 415     
Glu Asp Leu Thr Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly
            420                 425                 430         
Ser Leu Gln His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro
        435                 440                 445             
Ala Leu Pro Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu
    450                 455                 460                 
Pro His Glu Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys
465                 470                 475                 480 
Ile Leu Asp Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His
                485                 490                 495     
Leu Gln Leu Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro
            500                 505                 510         
Leu Cys Leu Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln
        515                 520                 525             
Lys Ser Trp Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val
    530                 535                 540                 
Pro Gly Asn Val Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn
545                 550                 555                 560 
Thr Leu Arg Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val
                565                 570                 575     
His Trp Ala Glu Cys Leu Gln Lys Thr Gly Ser Gly Leu Asn Ser Phe
            580                 585                 590         
Tyr Asp Gln Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys
        595                 600                 605             
Val Leu Pro Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu
    610                 615                 620                 
Pro Ile Asp Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala
625                 630                 635                 640 
Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala His Ile Thr Phe Ala Ile
                645                 650                 655     
Leu Asp Ala Val Asn Gly Asn Ile Glu Asp Ala Val Thr Ala Phe Glu
            660                 665                 670         
Ser Ile Lys Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His
        675                 680                 685             
Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala Leu Ser Pro Glu Glu Gln
    690                 695                 700                 
Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr Arg Asp Tyr Leu Ile Lys
705                 710                 715                 720 
Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro
                725                 730                 735     
Val Pro Leu Glu Ser Val Lys Glu Met Leu Asn Ser Val Met Gln Glu
            740                 745                 750         
Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu
        755                 760                 765             
Arg Asn Ala Asp Ser Glu Ile Lys Arg Ser Thr Pro Ser Pro Thr Arg
    770                 775                 780                 
Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro
785                 790                 795                 800 
Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Cys Gln
                805                 810                 815     
Gln Val Glu Ala Ile Lys Lys Glu Met Gln Glu Leu Lys Leu Asn Ser
            820                 825                 830         
Ser Asn Ser Ala Ser Pro His Arg Trp Pro Thr Glu Asn Tyr Gly Pro
        835                 840                 845             
Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala
    850                 855                 860                 
Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser
865                 870                 875                 880 
Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr
                885                 890                 895     
Pro Thr Lys Gly Pro Val Tyr Gly Met Asn Arg Leu Pro Pro Gln Gln
            900                 905                 910         
His Ile Tyr Ala Tyr Pro Gln Gln Met His Thr Pro Pro Val Gln Ser
        915                 920                 925             
Ser Ser Ala Cys Met Phe Ser Gln Glu Met Tyr Gly Pro Pro Ala Leu
    930                 935                 940                 
Arg Phe Glu Ser Pro Ala Thr Gly Ile Leu Ser Pro Arg Gly Asp Asp
945                 950                 955                 960 
Tyr Phe Asn Tyr Asn Val Gln Gln Thr Ser Thr Asn Pro Pro Leu Pro
                965                 970                 975     
Glu Pro Gly Tyr Phe Thr Lys Pro Pro Ile Ala Ala His Ala Ser Arg
            980                 985                 990         
Ser Ala Glu Ser Lys Thr Ile Glu Phe Gly Lys Thr Asn Phe Val Gln
        995                 1000                1005            
Pro Met Pro Gly Glu Gly Leu Arg Pro Ser Leu Pro Thr Gln Ala His
    1010                1015                1020                
Thr Thr Gln Pro Thr Pro Phe Lys Phe Asn Ser Asn Phe Lys Ser Asn
1025                1030                1035                1040
Asp Gly Asp Phe Thr Phe Ser Ser Pro Gln Val Val Thr Gln Pro Pro
                1045                1050                1055    
Pro Ala Ala Tyr Ser Asn Ser Glu Ser Leu Leu Gly Leu Leu Thr Ser
            1060                1065                1070        
Asp Lys Pro Leu Gln Gly Asp Gly Tyr Ser Gly Ala Lys Pro Ile Pro
        1075                1080                1085            
Gly Gly Gln Thr Ile Gly Pro Arg Asn Thr Phe Asn Phe Gly Ser Lys
    1090                1095                1100                
Asn Val Ser Gly Ile Ser Phe Thr Glu Asn Met Gly Ser Ser Gln Gln
1105                1110                1115                1120
Lys Asn Ser Gly Phe Arg Arg Ser Asp Asp Met Phe Thr Phe His Gly
                1125                1130                1135    
Pro Gly Lys Ser Val Phe Gly Thr Pro Thr Leu Glu Thr Ala Asn Lys
            1140                1145                1150        
Asn His Glu Thr Asp Gly Gly Ser Ala His Gly Asp Asp Asp Asp Asp
        1155                1160                1165            
Gly Pro His Phe Glu Pro Val Val Pro Leu Pro Asp Lys Ile Glu Val
    1170                1175                1180                
Lys Thr Gly Glu Glu Asp Glu Glu Glu Phe Phe Cys Asn Arg Ala Lys
1185                1190                1195                1200
Leu Phe Arg Phe Asp Val Glu Ser Lys Glu Trp Lys Glu Arg Gly Ile
                1205                1210                1215    
Gly Asn Val Lys Ile Leu Arg His Lys Thr Ser Gly Lys Ile Arg Leu
            1220                1225                1230        
Leu Met Arg Arg Glu Gln Val Leu Lys Ile Cys Ala Asn His Tyr Ile
        1235                1240                1245            
Ser Pro Asp Met Lys Leu Thr Pro Asn Ala Gly Ser Asp Arg Ser Phe
    1250                1255                1260                
Val Trp His Ala Leu Asp Tyr Ala Asp Glu Leu Pro Lys Pro Glu Gln
1265                1270                1275                1280
Leu Ala Ile Arg Phe Lys Thr Pro Glu Glu Ala Ala Leu Phe Lys Cys
                1285                1290                1295    
Lys Phe Glu Glu Ala Gln Ser Ile Leu Lys Ala Pro Gly Thr Asn Val
            1300                1305                1310        
Ala Met Ala Ser Asn Gln Ala Val Arg Ile Val Lys Glu Pro Thr Ser
        1315                1320                1325            
His Asp Asn Lys Asp Ile Cys Lys Ser Asp Ala Gly Asn Leu Asn Phe
    1330                1335                1340                
Glu Phe Gln Val Ala Lys Lys Glu Gly Ser Trp Trp His Cys Asn Ser
1345                1350                1355                1360
Cys Ser Leu Lys Asn Ala Ser Thr Ala Lys Lys Cys Val Ser Cys Gln
                1365                1370                1375    
Asn Leu Asn Pro Ser Asn Lys Glu Leu Val Gly Pro Pro Leu Ala Glu
            1380                1385                1390        
Thr Val Phe Thr Pro Lys Thr Ser Pro Glu Asn Val Gln Asp Arg Phe
        1395                1400                1405            
Ala Leu Val Thr Pro Lys Lys Glu Gly His Trp Asp Cys Ser Ile Cys
    1410                1415                1420                
Leu Val Arg Asn Glu Pro Thr Val Ser Arg Cys Ile Ala Cys Gln Asn
1425                1430                1435                1440
Thr Lys Ser Ala Asn Lys Ser Gly Ser Ser Phe Val His Gln Ala Ser
                1445                1450                1455    
Phe Lys Phe Gly Gln Gly Asp Leu Pro Lys Pro Ile Asn Ser Asp Phe
            1460                1465                1470        
Arg Ser Val Phe Ser Thr Lys Glu Gly Gln Trp Asp Cys Ser Ala Cys
        1475                1480                1485            
Leu Val Gln Asn Glu Gly Ser Ser Thr Lys Cys Ala Ala Cys Gln Asn
    1490                1495                1500                
Pro Arg Lys Gln Ser Leu Pro Ala Thr Ser Ile Pro Thr Pro Ala Ser
1505                1510                1515                1520
Phe Lys Phe Gly Thr Ser Glu Thr Ser Lys Thr Leu Lys Ser Gly Phe
                1525                1530                1535    
Glu Asp Met Phe Ala Lys Lys Glu Gly Gln Trp Asp Cys Ser Ser Cys
            1540                1545                1550        
Leu Val Arg Asn Glu Ala Asn Ala Thr Arg Cys Val Ala Cys Gln Asn
        1555                1560                1565            
Pro Asp Lys Pro Ser Pro Ser Thr Ser Val Pro Ala Pro Ala Ser Phe
    1570                1575                1580                
Lys Phe Gly Thr Ser Glu Thr Ser Lys Ala Pro Lys Ser Gly Phe Glu
1585                1590                1595                1600
Gly Met Phe Thr Lys Lys Glu Gly Gln Trp Asp Cys Ser Val Cys Leu
                1605                1610                1615    
Val Arg Asn Glu Ala Ser Ala Thr Lys Cys Ile Ala Cys Gln Asn Pro
            1620                1625                1630        
Gly Lys Gln Asn Gln Thr Thr Ser Ala Val Ser Thr Pro Ala Ser Ser
        1635                1640                1645            
Glu Thr Ser Lys Ala Pro Lys Ser Gly Phe Glu Gly Met Phe Thr Lys
    1650                1655                1660                
Lys Glu Gly Gln Trp Asp Cys Ser Val Cys Leu Val Arg Asn Glu Ala
1665                1670                1675                1680
Ser Ala Thr Lys Cys Ile Ala Cys Gln Asn Pro Gly Lys Gln Asn Gln
                1685                1690                1695    
Thr Thr Ser Ala Val Ser Thr Pro Ala Ser Ser Glu Thr Ser Lys Ala
            1700                1705                1710        
Pro Lys Ser Gly Phe Glu Gly Met Phe Thr Lys Lys Glu Gly Gln Trp
        1715                1720                1725            
Asp Cys Ser Val Cys Leu Val Arg Asn Glu Ala Ser Ala Thr Lys Cys
    1730                1735                1740                
Ile Ala Cys Gln Cys Pro Ser Lys Gln Asn Gln Thr Thr Ala Ile Ser
1745                1750                1755                1760
Thr Pro Ala Ser Ser Glu Ile Ser Lys Ala Pro Lys Ser Gly Phe Glu
                1765                1770                1775    
Gly Met Phe Ile Arg Lys Gly Gln Trp Asp Cys Ser Val Cys Cys Val
            1780                1785                1790        
Gln Asn Glu Ser Ser Ser Leu Lys Cys Val Ala Cys Asp Ala Ser Lys
        1795                1800                1805            
Pro Thr His Lys Pro Ile Ala Glu Ala Pro Ser Ala Phe Thr Leu Gly
    1810                1815                1820                
Ser Glu Met Lys Leu His Asp Ser Ser Gly Ser Gln Val Gly Thr Gly
1825                1830                1835                1840
Phe Lys Ser Asn Phe Ser Glu Lys Ala Ser Lys Phe Gly Asn Thr Glu
                1845                1850                1855    
Gln Gly Phe Lys Phe Gly His Val Asp Gln Glu Asn Ser Pro Ser Phe
            1860                1865                1870        
Met Phe Gln Gly Ser Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu Gly
        1875                1880                1885            
Phe Ser Ile Pro Val Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser Glu
    1890                1895                1900                
Pro Gly Asn Gln Glu Lys Lys Ser Glu Lys Pro Leu Glu Asn Gly Thr
1905                1910                1915                1920
Gly Phe Gln Ala Gln Asp Ile Ser Gly Gln Lys Asn Gly Arg Gly Val
                1925                1930                1935    
Ile Phe Gly Gln Thr Ser Ser Thr Phe Thr Phe Ala Asp Leu Ala Lys
            1940                1945                1950        
Ser Thr Ser Gly Glu Gly Phe Gln Phe Gly Lys Lys Asp Pro Asn Phe
        1955                1960                1965            
Lys Gly Phe Ser Gly Ala Gly Glu Lys Leu Phe Ser Ser Gln Tyr Gly
    1970                1975                1980                
Lys Met Ala Asn Lys Ala Asn Thr Ser Gly Asp Phe Glu Lys Asp Asp
1985                1990                1995                2000
Asp Ala Tyr Lys Thr Glu Asp Ser Asp Asp Ile His Phe Glu Pro Val
                2005                2010                2015    
Val Gln Met Pro Glu Lys Val Glu Leu Val Thr Gly Glu Glu Asp Glu
            2020                2025                2030        
Lys Val Leu Tyr Ser Gln Arg Val Lys Leu Phe Arg Phe Asp Ala Glu
        2035                2040                2045            
Val Ser Gln Trp Lys Glu Arg Gly Leu Gly Asn Leu Lys Ile Leu Lys
    2050                2055                2060                
Asn Glu Val Asn Gly Lys Leu Arg Met Leu Met Arg Arg Glu Gln Val
2065                2070                2075                2080
Leu Lys Val Cys Ala Asn His Trp Ile Thr Thr Thr Met Asn Leu Lys
                2085                2090                2095    
Pro Leu Ser Gly Ser Asp Arg Ala Trp Met Trp Leu Ala Ser Asp Phe
            2100                2105                2110        
Ser Asp Gly Asp Ala Lys Leu Glu Gln Leu Ala Ala Lys Phe Lys Thr
        2115                2120                2125            
Pro Glu Leu Ala Glu Glu Phe Lys Gln Lys Phe Glu Glu Cys Gln Arg
    2130                2135                2140                
Leu Leu Leu Asp Ile Pro Leu Gln Thr Pro His Lys Leu Val Asp Thr
2145                2150                2155                2160
Gly Arg Ala Ala Lys Leu Ile Gln Arg Ala Glu Glu Met Lys Ser Gly
                2165                2170                2175    
Leu Lys Asp Phe Lys Thr Phe Leu Thr Asn Asp Gln Thr Lys Val Thr
            2180                2185                2190        
Glu Glu Glu Asn Lys Gly Ser Gly Thr Gly Ala Ala Gly Ala Ser Asp
        2195                2200                2205            
Thr Thr Ile Lys Pro Asn Pro Glu Asn Thr Gly Pro Thr Leu Glu Trp
    2210                2215                2220                
Asp Asn Tyr Asp Leu Arg Glu Asp Ala Leu Asp Asp Ser Val Ser Ser
2225                2230                2235                2240
Ser Ser Val His Ala Ser Pro Leu Ala Ser Ser Pro Val Arg Lys Asn
                2245                2250                2255    
Leu Phe Arg Phe Gly Glu Ser Thr Thr Gly Phe Asn Phe Ser Phe Lys
            2260                2265                2270        
Ser Ala Leu Ser Pro Ser Lys Ser Pro Ala Lys Leu Asn Gln Ser Gly
        2275                2280                2285            
Thr Ser Val Gly Thr Asp Glu Glu Ser Asp Val Thr Gln Glu Glu Glu
    2290                2295                2300                
Arg Asp Gly Gln Tyr Phe Glu Pro Val Val Pro Leu Pro Asp Leu Val
2305                2310                2315                2320
Glu Val Ser Ser Gly Glu Glu Asn Glu Gln Val Val Phe Ser His Arg
                2325                2330                2335    
Ala Lys Leu Tyr Arg Tyr Asp Lys Asp Val Gly Gln Trp Lys Glu Arg
            2340                2345                2350        
Gly Ile Gly Asp Ile Lys Ile Leu Gln Asn Tyr Asp Asn Lys Gln Val
        2355                2360                2365            
Arg Ile Val Met Arg Arg Asp Gln Val Leu Lys Leu Cys Ala Asn His
    2370                2375                2380                
Arg Ile Thr Pro Asp Met Thr Leu Gln Asn Met Lys Gly Thr Glu Arg
2385                2390                2395                2400
Val Trp Leu Trp Thr Ala Cys Asp Phe Ala Asp Gly Glu Arg Lys Val
                2405                2410                2415    
Glu His Leu Ala Val Arg Phe Lys Leu Gln Asp Val Ala Asp Ser Phe
            2420                2425                2430        
Lys Lys Ile Phe Asp Glu Ala Lys Thr Ala Gln Glu Lys Asp Ser Leu
        2435                2440                2445            
Ile Thr Pro His Val Ser Arg Ser Ser Thr Pro Arg Glu Ser Pro Cys
    2450                2455                2460                
Gly Lys Ile Ala Val Ala Val Leu Glu Glu Thr Thr Arg Glu Arg Thr
2465                2470                2475                2480
Asp Val Ile Gln Gly Asp Asp Val Ala Asp Ala Thr Ser Glu Val Glu
                2485                2490                2495    
Val Ser Ser Thr Ser Glu Thr Thr Pro Lys Ala Val Val Ser Pro Pro
            2500                2505                2510        
Lys Phe Val Phe Gly Ser Glu Ser Val Lys Ser Ile Phe Ser Ser Glu
        2515                2520                2525            
Lys Ser Lys Pro Phe Ala Phe Gly Asn Ser Ser Ala Thr Gly Ser Leu
    2530                2535                2540                
Phe Gly Phe Ser Phe Asn Ala Pro Leu Lys Ser Asn Asn Ser Glu Thr
2545                2550                2555                2560
Ser Ser Val Ala Gln Ser Gly Ser Glu Ser Lys Val Glu Pro Lys Lys
                2565                2570                2575    
Cys Glu Leu Ser Lys Asn Ser Asp Ile Glu Gln Ser Ser Asp Ser Lys
            2580                2585                2590        
Val Lys Asn Leu Phe Ala Ser Phe Pro Thr Glu Glu Ser Ser Ile Asn
        2595                2600                2605            
Tyr Thr Phe Lys Thr Pro Glu Lys Ala Lys Glu Lys Lys Lys Pro Glu
    2610                2615                2620                
Asp Ser Pro Ser Asp Asp Asp Val Leu Ile Val Tyr Glu Leu Thr Pro
2625                2630                2635                2640
Thr Ala Glu Gln Lys Ala Leu Ala Thr Lys Leu Lys Leu Pro Pro Thr
                2645                2650                2655    
Phe Phe Cys Tyr Lys Asn Arg Pro Asp Tyr Val Ser Glu Glu Glu Glu
            2660                2665                2670        
Asp Asp Glu Asp Phe Glu Thr Ala Val Lys Lys Leu Asn Gly Lys Leu
        2675                2680                2685            
Tyr Leu Asp Gly Ser Glu Lys Cys Arg Pro Leu Glu Glu Asn Thr Ala
    2690                2695                2700                
Asp Asn Glu Lys Glu Cys Ile Ile Val Trp Glu Lys Lys Pro Thr Val
2705                2710                2715                2720
Glu Glu Lys Ala Lys Ala Asp Thr Leu Lys Leu Pro Pro Thr Phe Phe
                2725                2730                2735    
Cys Gly Val Cys Ser Asp Thr Asp Glu Asp Asn Gly Asn Gly Glu Asp
            2740                2745                2750        
Phe Gln Ser Glu Leu Gln Lys Val Gln Glu Ala Gln Lys Ser Gln Thr
        2755                2760                2765            
Glu Glu Ile Thr Ser Thr Thr Asp Ser Val Tyr Thr Gly Gly Thr Glu
    2770                2775                2780                
Val Met Val Pro Ser Phe Cys Lys Ser Glu Glu Pro Asp Ser Ile Thr
2785                2790                2795                2800
Lys Ser Ile Ser Ser Pro Ser Val Ser Ser Glu Thr Met Asp Lys Pro
                2805                2810                2815    
Val Asp Leu Ser Thr Arg Lys Glu Ile Asp Thr Asp Ser Thr Ser Gln
            2820                2825                2830        
Gly Glu Ser Lys Ile Val Ser Phe Gly Phe Gly Ser Ser Thr Gly Leu
        2835                2840                2845            
Ser Phe Ala Asp Leu Ala Ser Ser Asn Ser Gly Asp Phe Ala Phe Gly
    2850                2855                2860                
Ser Lys Asp Lys Asn Phe Gln Trp Ala Asn Thr Gly Ala Ala Val Phe
2865                2870                2875                2880
Gly Thr Gln Ser Val Gly Thr Gln Ser Ala Gly Lys Val Gly Glu Asp
                2885                2890                2895    
Glu Asp Gly Ser Asp Glu Glu Val Val His Asn Glu Asp Ile His Phe
            2900                2905                2910        
Glu Pro Ile Val Ser Leu Pro Glu Val Glu Val Lys Ser Gly Glu Glu
        2915                2920                2925            
Asp Glu Glu Ile Leu Phe Lys Glu Arg Ala Lys Leu Tyr Arg Trp Asp
    2930                2935                2940                
Arg Asp Val Ser Gln Trp Lys Glu Arg Gly Val Gly Asp Ile Lys Ile
2945                2950                2955                2960
Leu Trp His Thr Met Lys Asn Tyr Tyr Arg Ile Leu Met Arg Arg Asp
                2965                2970                2975    
Gln Val Phe Lys Val Cys Ala Asn His Val Ile Thr Lys Thr Met Glu
            2980                2985                2990        
Leu Lys Pro Leu Asn Val Ser Asn Asn Ala Leu Val Trp Thr Ala Ser
        2995                3000                3005            
Asp Tyr Ala Asp Gly Glu Ala Lys Val Glu Gln Leu Ala Val Arg Phe
    3010                3015                3020                
Lys Thr Lys Glu Val Ala Asp Cys Phe Lys Lys Thr Phe Glu Glu Cys
3025                3030                3035                3040
Gln Gln Asn Leu Met Lys Leu Gln Lys Gly His Val Ser Leu Ala Ala
                3045                3050                3055    
Glu Leu Ser Lys Glu Thr Asn Pro Val Val Phe Phe Asp Val Cys Ala
            3060                3065                3070        
Asp Gly Glu Pro Leu Gly Arg Ile Thr Met Glu Leu Phe Ser Asn Ile
        3075                3080                3085            
Val Pro Arg Thr Ala Glu Asn Phe Arg Ala Leu Cys Thr Gly Glu Lys
    3090                3095                3100                
Gly Phe Gly Phe Lys Asn Ser Ile Phe His Arg Val Ile Pro Asp Phe
3105                3110                3115                3120
Val Cys Gln Gly Gly Asp Ile Thr Lys His Asp Gly Thr Gly Gly Gln
                3125                3130                3135    
Ser Ile Tyr Gly Asp Lys Phe Glu Asp Glu Asn Phe Asp Val Lys His
            3140                3145                3150        
Thr Gly Pro Gly Leu Leu Ser Met Ala Asn Gln Gly Gln Asn Thr Asn
        3155                3160                3165            
Asn Ser Gln Phe Val Ile Thr Leu Lys Lys Ala Glu His Leu Asp Phe
    3170                3175                3180                
Lys His Val Val Phe Gly Phe Val Lys Asp Gly Met Asp Thr Val Lys
3185                3190                3195                3200
Lys Ile Glu Ser Phe Gly Ser Pro Lys Gly Ser Val Cys Arg Arg Ile
                3205                3210                3215    
Thr Ile Thr Glu Cys Gly Gln Ile
            3220                


<210> 7075
<211> 2620
<212> PRT
<213> Homo sapiens

<400> 7075
Met Thr Asn Phe Tyr Glu Glu Arg Thr Thr Met Ile Ala Ala Arg Asp
 1               5                  10                  15      
Leu Gln Glu Phe Val Pro Phe Gly Gly Asp His Cys Lys His His Pro
            20                  25                  30          
Asn Ala Leu Asn Leu Gln Leu Arg Gln Leu Gln Pro Ala Ser Glu Leu
        35                  40                  45              
Trp Ser Ser Asp Gly Ala Ala Gly Leu Val Gly Ser Leu Gln Glu Val
    50                  55                  60                  
Thr Ile His Glu Lys Gln Lys Glu Asn Trp Gln Leu Arg Lys Gly Val
65                  70                  75                  80  
Ser Glu Ile Gly Glu Asp Val Asp Tyr Asp Glu Glu Leu Tyr Val Ala
                85                  90                  95      
Gly Asn Met Val Ile Trp Ser Lys Gly Ser Lys Ser Gln Ala Leu Ala
            100                 105                 110         
Val Tyr Lys Ala Phe Thr Val Asp Ser Pro Val Gln Gln Val Gly Lys
        115                 120                 125             
Val Phe Ile Pro Gly Leu Pro Ala Pro Ser Leu Thr Met Ser Asn Thr
    130                 135                 140                 
Met Pro Arg Pro Ser Thr Pro Leu Asp Gly Val Ser Ala Pro Lys Pro
145                 150                 155                 160 
Leu Ser Lys Leu Leu Gly Ser Leu Asp Glu Asp Thr Ser Ser Ser Gln
                165                 170                 175     
Trp Ser Ser Ala Gly Tyr Ala Ala Ala Ser Val Ala Phe Arg Arg Phe
            180                 185                 190         
Pro Leu Gly Ile Gly Asp Cys Cys Gly Ala Glu Arg Trp Ser His Ala
        195                 200                 205             
Ser Arg Glu Pro Gly Trp Trp Arg Asp Glu Leu Gln Gln Gly Leu Arg
    210                 215                 220                 
Gly Ala Val Arg Arg Leu Gly Ala Gly Leu Arg Pro Val Ala Ser Lys
225                 230                 235                 240 
Gly Val Met Ala Pro Asp Glu Arg Cys Ser Leu Ala Arg Ser Val Glu
                245                 250                 255     
Ala Ala Ala Ser Thr Trp Pro Cys Gly Gly Leu Asp Gly Ser Gly Val
            260                 265                 270         
Met Ala Pro Asp Arg Arg Cys Ser Leu Ala Arg Ser Val Glu Ala Pro
        275                 280                 285             
Ala Ser Thr Trp Pro Cys Gly Gly Leu Asp Gly Ser Gly Val Met Ala
    290                 295                 300                 
Pro Asp Gly Arg Cys Ser Leu Ala Arg Ser Val Glu Ala Pro Ala Ser
305                 310                 315                 320 
Thr Trp Pro Cys Gly Gly Leu Asp Gly Ser Gly Val Met Ala Pro Asp
                325                 330                 335     
Gly Arg Cys Ser Leu Ala Arg Ser Val Glu Ala Ala Ala Ser Thr Trp
            340                 345                 350         
Pro Gly Gly Cys Leu Asp Gly Ser Gly Val Met Ala Pro Asp Gly Arg
        355                 360                 365             
Cys Ser Leu Ala Arg Ser Val Glu Ala Ala Ala Ser Thr Trp Pro Gly
    370                 375                 380                 
Gly Cys Leu Asp Gly Ser Gly Val Met Ala Pro Asp Gly Arg Cys Ser
385                 390                 395                 400 
Leu Ala Arg Ser Val Glu Ala Ala Ala Ser Thr Arg Pro Gly Gly Cys
                405                 410                 415     
Leu Asp Gly Ser Gly Ile Met Ala Pro Asp Gly Arg Cys Ser Leu Ala
            420                 425                 430         
Arg Ser Val Glu Ala Ala Ala Ser Thr Arg Pro Ser Gly Gly Leu Asp
        435                 440                 445             
Gly Ser Gly Val Met Ala Pro Asp Gly Arg Cys Ser Leu Ala Arg Ser
    450                 455                 460                 
Val Glu Ala Ala Ala Ser Thr Arg Pro Gly Gly Gly Leu Asp Gly Ser
465                 470                 475                 480 
Gly Val Met Ala Pro Asp Gly Arg Cys Ser Leu Ala Arg Ser Val Glu
                485                 490                 495     
Ala Ala Ala Ser Thr Trp Pro Cys Gly Gly Leu Asp Gly Ser Gly Val
            500                 505                 510         
Met Ala Pro Asp Gly Arg Cys Ser Leu Ala Arg Ser Val Glu Ala Ala
        515                 520                 525             
Ala Ser Thr Arg Pro Gly Gly Gly Leu Asp Gly Ser Gly Val Met Ala
    530                 535                 540                 
Pro Asp Gly Arg Cys Ser Leu Ala Arg Ser Val Glu Ala Ala Ala Ser
545                 550                 555                 560 
Met Ala Gln Ala Ser Trp Leu Pro Thr Gly Ala Ala Pro Trp Arg Ala
                565                 570                 575     
Leu Leu Arg Arg Arg Pro Arg Pro Gly Pro Ala Ala Ala Ser Met Ala
            580                 585                 590         
Gln Ala Ser Trp Leu Pro Thr Gly Ala Val Thr Trp Arg Ala Leu Leu
        595                 600                 605             
Arg Arg Arg Arg Arg Pro Arg Pro Gly Gln Ala Ala Ala Ala Ser Thr
    610                 615                 620                 
Trp Pro Cys Gly Gly Leu Asp Gly Ser Gly Val Met Ala Pro Asp Gly
625                 630                 635                 640 
Arg Cys Ser Leu Ala Arg Ser Val Glu Ala Ala Ala Ser Thr Arg Pro
                645                 650                 655     
Gly Gly Gly Leu Asp Gly Ser Gly Val Met Ala Pro Asp Gly Arg Cys
            660                 665                 670         
Ser Leu Ala Arg Ser Val Glu Ala Ala Ala Ser Thr Arg Pro Cys Gly
        675                 680                 685             
Gly Leu Asp Gly Ser Gly Val Met Ala Pro Asp Gly Arg Cys Ser Leu
    690                 695                 700                 
Ala Arg Ser Val Glu Ala Ala Ala Ser Thr Arg Pro Gly Gly Gly Leu
705                 710                 715                 720 
Asp Gly Ser Gly Lys Ser Thr Arg Gly Phe Tyr Phe Ala Lys Leu Tyr
                725                 730                 735     
Tyr Glu Ala Lys Glu Tyr Asp Leu Ala Lys Lys Tyr Ile Cys Thr Tyr
            740                 745                 750         
Ile Asn Val Arg Glu Met Asp Pro Arg Ala His Arg Phe Leu Gly Leu
        755                 760                 765             
Leu Tyr Glu Leu Glu Glu Asn Thr Glu Lys Ala Val Glu Cys Tyr Arg
    770                 775                 780                 
Arg Ser Val Glu Leu Asn Pro Thr Gln Lys Asp Leu Val Leu Lys Ile
785                 790                 795                 800 
Ala Glu Leu Leu Cys Lys Asn Asp Val Thr Asp Gly Arg Ala Glu Tyr
                805                 810                 815     
Trp Val Glu Arg Ala Ala Lys Leu Phe Pro Gly Ser Pro Ala Ile Tyr
            820                 825                 830         
Lys Leu Lys Glu Gln Leu Leu Asp Cys Glu Gly Glu Asp Gly Trp Asn
        835                 840                 845             
Lys Leu Phe Asp Leu Ile Gln Ser Glu Leu Tyr Val Arg Pro Asp Asp
    850                 855                 860                 
Val His Val Asn Ile Arg Leu Val Glu Leu Tyr Arg Ser Thr Lys Arg
865                 870                 875                 880 
Leu Lys Asp Ala Val Ala Arg Cys His Glu Ala Glu Arg Asn Ile Ala
                885                 890                 895     
Leu Arg Ser Ser Leu Glu Trp Asn Ser Cys Val Val Gln Thr Leu Lys
            900                 905                 910         
Glu Tyr Leu Glu Ser Leu Gln Cys Leu Glu Ser Asp Lys Ser Asp Trp
        915                 920                 925             
Arg Ala Thr Asn Thr Asp Leu Leu Leu Ala Tyr Ala Asn Leu Met Leu
    930                 935                 940                 
Leu Thr Leu Ser Thr Arg Asp Val Gln Glu Ser Arg Glu Leu Leu Glu
945                 950                 955                 960 
Ser Phe Asp Ser Ala Leu Gln Ser Ala Lys Ser Ser Leu Gly Gly Asn
                965                 970                 975     
Asp Glu Leu Ser Ala Thr Phe Leu Glu Met Lys Gly His Phe Tyr Met
            980                 985                 990         
His Ala Gly Ser Leu Leu Leu Lys Met Gly Gln His Gly Asn Asn Val
        995                 1000                1005            
Gln Trp Arg Ala Leu Ser Glu Leu Ala Ala Leu Cys Tyr Leu Ile Ala
    1010                1015                1020                
Phe Gln Val Pro Arg Pro Lys Ile Lys Leu Ile Lys Gly Glu Ala Gly
1025                1030                1035                1040
Gln Asn Leu Leu Glu Met Met Ala Cys Asp Arg Leu Ser Gln Ser Gly
                1045                1050                1055    
His Met Leu Leu Asn Leu Ser Arg Gly Lys Gln Asp Phe Leu Lys Val
            1060                1065                1070        
Val Val Glu Thr Phe Ala Asn Lys Ser Gly Gln Ser Ala Leu Tyr Asp
        1075                1080                1085            
Ala Leu Phe Ser Ser Gln Ser Pro Lys Asp Thr Ser Phe Leu Gly Ser
    1090                1095                1100                
Asp Asp Ile Gly Asn Ile Asp Val Gln Glu Pro Glu Leu Glu Asp Leu
1105                1110                1115                1120
Ala Arg Tyr Asp Val Gly Ala Ile Arg Ala His Asn Gly Ser Leu Gln
                1125                1130                1135    
His Leu Thr Trp Leu Gly Leu Gln Trp Asn Ser Leu Pro Ala Leu Pro
            1140                1145                1150        
Gly Ile Arg Lys Trp Leu Lys Gln Leu Phe His His Leu Pro Gln Glu
        1155                1160                1165            
Thr Ser Arg Leu Glu Thr Asn Ala Pro Glu Ser Ile Cys Ile Leu Asp
    1170                1175                1180                
Leu Glu Val Phe Leu Leu Gly Val Val Tyr Thr Ser His Leu Gln Leu
1185                1190                1195                1200
Lys Glu Lys Cys Asn Ser His His Ser Ser Tyr Gln Pro Leu Cys Leu
                1205                1210                1215    
Pro Leu Pro Val Cys Lys Gln Leu Cys Thr Glu Arg Gln Lys Ser Trp
            1220                1225                1230        
Trp Asp Ala Val Cys Thr Leu Ile His Arg Lys Ala Val Pro Gly Asn
        1235                1240                1245            
Ser Ala Lys Leu Arg Leu Leu Val Gln His Glu Ile Asn Thr Leu Arg
    1250                1255                1260                
Ala Gln Glu Lys His Gly Leu Gln Pro Ala Leu Leu Val His Trp Ala
1265                1270                1275                1280
Lys Cys Leu Gln Lys Met Gly Ser Gly Leu Asn Ser Phe Tyr Asp Gln
                1285                1290                1295    
Arg Glu Tyr Ile Gly Arg Ser Val His Tyr Trp Lys Lys Val Leu Pro
            1300                1305                1310        
Leu Leu Lys Ile Ile Lys Lys Lys Asn Ser Ile Pro Glu Pro Ile Asp
        1315                1320                1325            
Pro Leu Phe Lys His Phe His Ser Val Asp Ile Gln Ala Ser Glu Ile
    1330                1335                1340                
Val Glu Tyr Glu Glu Asp Ala His Val Thr Phe Ala Ile Leu Asp Ala
1345                1350                1355                1360
Val Asn Gly Asn Ile Glu Asp Ala Met Thr Ala Phe Glu Ser Ile Lys
                1365                1370                1375    
Ser Val Val Ser Tyr Trp Asn Leu Ala Leu Ile Phe His Arg Lys Ala
            1380                1385                1390        
Glu Asp Ile Ala Asn Asp Ala Leu Ser Pro Glu Glu Gln Glu Glu Cys
        1395                1400                1405            
Lys Asn Tyr Leu Arg Lys Thr Arg Gly Tyr Leu Ile Lys Ile Leu Asp
    1410                1415                1420                
Asp Ser Asp Ser Asn Leu Ser Val Val Lys Lys Leu Pro Val Pro Leu
1425                1430                1435                1440
Glu Ser Val Lys Glu Met Leu Lys Ser Val Met Gln Glu Leu Glu Asn
                1445                1450                1455    
Tyr Ser Glu Gly Gly Pro Leu Tyr Lys Asn Gly Ser Leu Arg Asn Ala
            1460                1465                1470        
Asp Ser Glu Ile Lys His Ser Thr Pro Ser Pro Thr Lys Tyr Ser Leu
        1475                1480                1485            
Ser Pro Ser Lys Ser Tyr Lys Tyr Ser Pro Lys Thr Pro Pro Arg Trp
    1490                1495                1500                
Ala Glu Asp Gln Asn Ser Leu Leu Lys Met Ile Arg Gln Glu Val Lys
1505                1510                1515                1520
Ala Ile Lys Glu Glu Met Gln Glu Leu Lys Leu Asn Ser Ser Lys Ser
                1525                1530                1535    
Ala Ser His His Arg Trp Pro Thr Glu Asn Tyr Gly Pro Asp Ser Val
            1540                1545                1550        
Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala Pro Leu Thr
        1555                1560                1565            
Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser Pro Ala Tyr
    1570                1575                1580                
Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr Pro Thr Lys
1585                1590                1595                1600
Gly Ser Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu Gly Phe Ser Ile
                1605                1610                1615    
Pro Val Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser Glu Pro Gly Asn
            1620                1625                1630        
Gln Glu Lys Lys Ser Glu Lys Pro Leu Glu Asn Asp Thr Gly Leu Gln
        1635                1640                1645            
Ala Gln Asp Ile Ser Gly Arg Lys Lys Gly Arg Gly Val Ile Phe Gly
    1650                1655                1660                
Gln Thr Ser Ser Thr Phe Thr Phe Ala Asp Val Ala Lys Ser Thr Ser
1665                1670                1675                1680
Gly Glu Gly Phe Gln Phe Gly Lys Lys Asp Leu Asn Phe Lys Gly Phe
                1685                1690                1695    
Ser Gly Ala Gly Glu Lys Leu Phe Ser Ser Gln Tyr Gly Lys Met Ala
            1700                1705                1710        
Asn Lys Ala Asn Thr Ser Gly Asp Phe Glu Lys Asp Asp Asp Ala Tyr
        1715                1720                1725            
Lys Thr Glu Asp Ser Asp Asp Ile His Phe Glu Pro Val Val Gln Met
    1730                1735                1740                
Pro Glu Lys Val Glu Leu Val Thr Gly Glu Glu Gly Glu Lys Val Leu
1745                1750                1755                1760
Tyr Ser Gln Gly Val Lys Leu Phe Arg Phe Asp Ala Glu Val Ser Gln
                1765                1770                1775    
Trp Lys Glu Arg Gly Leu Gly Asn Leu Lys Ile Leu Lys Asn Glu Val
            1780                1785                1790        
Asn Gly Lys Val Arg Met Leu Met Gln Arg Glu Gln Val Leu Lys Val
        1795                1800                1805            
Cys Ala Asn His Trp Ile Thr Thr Thr Met Asn Leu Lys Pro Leu Ser
    1810                1815                1820                
Gly Ser Asp Arg Ala Trp Met Trp Ser Ala Ser Asp Phe Ser Asp Gly
1825                1830                1835                1840
Asp Ala Lys Leu Glu Arg Leu Ala Ala Lys Phe Lys Thr Pro Glu Leu
                1845                1850                1855    
Ala Glu Glu Phe Lys Gln Lys Phe Glu Glu Cys Gln Arg Leu Leu Leu
            1860                1865                1870        
Asp Ile Pro Leu Gln Thr Pro His Lys Leu Val Asp Thr Gly Arg Ala
        1875                1880                1885            
Ala Lys Leu Ile Gln Arg Ala Glu Glu Met Lys Ser Gly Leu Lys Asp
    1890                1895                1900                
Phe Lys Thr Phe Leu Thr Asn Asp Gln Thr Lys Val Ala Glu Glu Glu
1905                1910                1915                1920
Asn Lys Gly Ser Gly Thr Gly Ala Ala Gly Ala Ser Asp Thr Thr Ile
                1925                1930                1935    
Lys Pro Asn Ala Glu Asn Thr Gly Pro Thr Leu Glu Trp Asp Asn Tyr
            1940                1945                1950        
Asp Leu Arg Glu Asp Ala Leu Asp Asp Ser Val Ser Ser Ser Ser Val
        1955                1960                1965            
His Ala Ser Pro Leu Ala Ser Ser Pro Val Arg Lys Asn Leu Phe His
    1970                1975                1980                
Phe Asp Glu Ser Thr Thr Gly Ser Asn Phe Ser Phe Lys Ser Ala Leu
1985                1990                1995                2000
Ser Leu Ser Lys Ser Pro Ala Lys Leu Asn Gln Ser Gly Thr Ser Val
                2005                2010                2015    
Gly Thr Asp Glu Glu Ser Asp Val Thr Gln Glu Glu Glu Arg Asp Gly
            2020                2025                2030        
Gln Tyr Phe Glu Pro Val Val Pro Leu Pro Asp Leu Val Glu Val Ser
        2035                2040                2045            
Ser Gly Glu Glu Asn Glu Gln Val Val Phe Ser His Arg Ala Glu Phe
    2050                2055                2060                
Tyr Arg Tyr Asp Lys Asp Val Gly Gln Trp Lys Glu Arg Gly Ile Gly
2065                2070                2075                2080
Asp Ile Lys Ile Leu Gln Asn Tyr Asp Asn Lys His Val Arg Ile Leu
                2085                2090                2095    
Met Arg Arg Asp Gln Val Leu Lys Leu Cys Ala Asn His Arg Ile Thr
            2100                2105                2110        
Pro Asp Met Ser Leu Gln Asn Met Lys Gly Thr Glu Arg Val Trp Val
        2115                2120                2125            
Trp Thr Ala Cys Asp Phe Ala Asp Gly Glu Arg Lys Val Glu His Leu
    2130                2135                2140                
Ala Val Arg Phe Lys Leu Gln Asp Val Ala Asp Ser Phe Lys Lys Ile
2145                2150                2155                2160
Phe Asp Glu Ala Lys Thr Ala Gln Glu Lys Asp Ser Leu Ile Thr Pro
                2165                2170                2175    
His Val Ser Arg Ser Ser Thr Pro Arg Glu Ser Pro Cys Gly Lys Ile
            2180                2185                2190        
Ala Val Ala Val Leu Glu Glu Thr Thr Arg Glu Arg Thr Asp Val Ile
        2195                2200                2205            
Gln Gly Asp Asp Val Ala Asp Ala Ala Ser Glu Val Glu Val Ser Ser
    2210                2215                2220                
Thr Ser Glu Thr Thr Thr Lys Ala Val Val Ser Pro Pro Lys Phe Val
2225                2230                2235                2240
Phe Gly Ser Glu Ser Val Lys Arg Ile Phe Ser Ser Glu Lys Ser Lys
                2245                2250                2255    
Pro Phe Ala Phe Gly Asn Ser Ser Ala Thr Gly Ser Leu Phe Gly Phe
            2260                2265                2270        
Ser Phe Asn Ala Pro Leu Lys Ser Asn Asn Ser Glu Thr Ser Ser Val
        2275                2280                2285            
Ala Gln Ser Gly Ser Glu Ser Lys Val Glu Pro Lys Lys Cys Glu Leu
    2290                2295                2300                
Ser Lys Asn Ser Asp Ile Glu Gln Ser Ser Asp Ser Lys Val Lys Asn
2305                2310                2315                2320
Leu Ser Ala Ser Phe Pro Thr Glu Glu Ser Ser Ile Asn Tyr Thr Phe
                2325                2330                2335    
Lys Thr Pro Glu Lys Gly Pro Val Ser Ser Gln Gln Ser Leu Lys Asn
            2340                2345                2350        
Leu Arg Glu Arg Arg Asn Thr Asp Leu Pro Leu Leu Asp Met His Thr
        2355                2360                2365            
Val Thr Arg Glu Glu Gly Glu Gly Met Glu Thr Thr Asp Thr Glu Ser
    2370                2375                2380                
Val Ser Ser Ala Ser Thr Tyr Thr Gln Ser Leu Glu Gln Leu Leu Asn
2385                2390                2395                2400
Ser Pro Glu Thr Lys Leu Glu Pro Pro Leu Trp Tyr Ala Glu Phe Thr
                2405                2410                2415    
Lys Glu Glu Leu Val Gln Lys Leu Ser Ser Thr Thr Lys Ser Ala Asp
            2420                2425                2430        
His Leu Asn Gly Leu Leu Arg Glu Ile Glu Ala Thr Asn Ala Val Leu
        2435                2440                2445            
Met Glu Gln Ile Lys Leu Leu Lys Ser Glu Ile Arg Arg Leu Glu Arg
    2450                2455                2460                
Asn Gln Glu Gln Glu Val Ser Ala Ala Asn Val Glu His Leu Lys Asn
2465                2470                2475                2480
Val Leu Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser Glu Arg Glu Arg
                2485                2490                2495    
Leu Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser Leu Glu Glu Lys
            2500                2505                2510        
Gly Lys Leu Ala Ala Val Ala Gln Val Leu His Ser Glu Arg Tyr Thr
        2515                2520                2525            
Glu Gly Lys Ser Thr Gln Arg Ser Lys Ser Phe Thr Arg His His Val
    2530                2535                2540                
Lys Gly Thr Arg Lys Gly Phe Lys Gln Arg Ser Tyr Ile Ser Ser Arg
2545                2550                2555                2560
Ser Gly Val Gln Leu Gln Val Ala Leu Thr Ser Gly Asp Arg Phe Leu
                2565                2570                2575    
Asp Ser Val Lys Ala Val Trp Leu Val Ala Ser Gly Arg Ser Lys Cys
            2580                2585                2590        
Asp Leu Thr Leu Thr Val Pro Gly Lys Thr Leu Ala Gly Phe Ile Gln
        2595                2600                2605            
Thr Leu Gly Pro Lys Asp His Gly His Pro Ala Glu
    2610                2615                2620


<210> 7076
<211> 1411
<212> PRT
<213> Homo sapiens

<400> 7076
Met Ala Cys Asp Arg Leu Ser Gln Ser Gly His Met Leu Leu Asn Leu
 1               5                  10                  15      
Ser Arg Gly Lys Gln Asp Phe Leu Lys Glu Val Val Glu Thr Phe Ala
            20                  25                  30          
Asn Lys Ser Gly Gln Ser Val Leu Tyr Asn Ala Leu Phe Ser Ser Gln
        35                  40                  45              
Ser Ser Lys Asp Thr Ser Phe Leu Gly Ser Asp Asp Ile Gly Asn Ile
    50                  55                  60                  
Asp Val Gln Glu Pro Glu Leu Glu Asp Leu Ala Arg Tyr Asp Val Gly
65                  70                  75                  80  
Ala Ile Gln Ala His Asn Gly Ser Leu Gln His Leu Thr Trp Leu Gly
                85                  90                  95      
Leu Gln Trp Asn Ser Leu Pro Ala Leu Pro Gly Ile Arg Lys Trp Leu
            100                 105                 110         
Lys Gln Leu Phe His His Leu Pro Gln Glu Thr Ser Arg Leu Glu Thr
        115                 120                 125             
Asn Ala Pro Glu Ser Ile Cys Ile Leu Asp Leu Glu Val Phe Leu Leu
    130                 135                 140                 
Gly Val Val Tyr Thr Ser His Leu Gln Leu Lys Glu Lys Cys Asn Ser
145                 150                 155                 160 
His His Ser Ser Tyr Gln Pro Leu Cys Leu Pro Leu Pro Val Cys Lys
                165                 170                 175     
Arg Leu Cys Thr Glu Arg Gln Lys Ser Trp Trp Asp Ala Val Cys Thr
            180                 185                 190         
Leu Ile His Arg Lys Ala Val Pro Gly Asn Ser Ala Glu Leu Arg Leu
        195                 200                 205             
Val Val Gln His Glu Ile Asn Thr Leu Arg Ala Gln Glu Lys His Gly
    210                 215                 220                 
Leu Gln Pro Ala Leu Leu Val His Trp Ala Lys Cys Leu Gln Lys Met
225                 230                 235                 240 
Gly Arg Gly Leu Asn Ser Ser Tyr Asp Gln Gln Glu Tyr Ile Gly Arg
                245                 250                 255     
Ser Val His Tyr Trp Lys Lys Val Leu Pro Leu Leu Lys Ile Ile Lys
            260                 265                 270         
Lys Asn Ser Ile Pro Glu Pro Ile Asp Pro Leu Phe Lys His Phe His
        275                 280                 285             
Ser Val Asp Ile Gln Ala Ser Glu Ile Val Glu Tyr Glu Glu Asp Ala
    290                 295                 300                 
His Ile Thr Phe Ala Ile Leu Asp Ala Val His Gly Asn Ile Glu Asp
305                 310                 315                 320 
Ala Val Thr Ala Phe Glu Ser Ile Lys Ser Val Val Ser Tyr Trp Asn
                325                 330                 335     
Leu Ala Leu Ile Phe His Arg Lys Ala Glu Asp Ile Glu Asn Asp Ala
            340                 345                 350         
Val Phe Pro Glu Glu Gln Glu Glu Cys Lys Asn Tyr Leu Arg Lys Thr
        355                 360                 365             
Arg Asp Tyr Leu Ile Lys Ile Ile Asp Asp Ser Asp Ser Asn Leu Ser
    370                 375                 380                 
Val Val Lys Lys Leu Pro Val Pro Leu Glu Ser Val Lys Glu Met Leu
385                 390                 395                 400 
Lys Ser Val Met Gln Glu Leu Glu Asp Tyr Ser Glu Gly Gly Pro Leu
                405                 410                 415     
Tyr Lys Asn Gly Ser Leu Arg Asn Ala Asp Ser Glu Ile Lys His Ser
            420                 425                 430         
Thr Pro Ser Pro Thr Lys Tyr Ser Leu Ser Pro Ser Lys Ser Tyr Lys
        435                 440                 445             
Tyr Ser Pro Lys Thr Pro Pro Arg Trp Ala Glu Asp Gln Asn Ser Leu
    450                 455                 460                 
Arg Lys Met Ile Cys Gln Glu Val Lys Ala Ile Thr Lys Leu Asn Ser
465                 470                 475                 480 
Ser Lys Ser Ala Ser Arg His Arg Trp Pro Thr Glu Asn Tyr Gly Pro
                485                 490                 495     
Asp Ser Val Pro Asp Gly Tyr Gln Gly Ser Gln Thr Phe His Gly Ala
            500                 505                 510         
Pro Leu Thr Val Ala Thr Thr Gly Pro Ser Val Tyr Tyr Ser Gln Ser
        515                 520                 525             
Pro Ala Tyr Asn Ser Gln Tyr Leu Leu Arg Pro Ala Ala Asn Val Thr
    530                 535                 540                 
Pro Thr Lys Gly Ser Ser Asn Thr Glu Phe Lys Ser Thr Lys Glu Gly
545                 550                 555                 560 
Phe Ser Ile Ala Val Ser Ala Asp Gly Phe Lys Phe Gly Ile Ser Glu
                565                 570                 575     
Pro Gly Asn Gln Glu Lys Lys Ser Glu Lys Pro Leu Glu Asn Asp Thr
            580                 585                 590         
Gly Phe Gln Ala Gln Asp Ile Ser Gly Gln Lys Asn Gly Arg Gly Val
        595                 600                 605             
Ile Phe Gly Gln Thr Ser Ser Thr Phe Thr Phe Ala Asp Val Ala Lys
    610                 615                 620                 
Ser Thr Ser Gly Glu Gly Phe Gln Phe Gly Lys Lys Asp Pro Asn Phe
625                 630                 635                 640 
Lys Gly Phe Ser Gly Ala Gly Glu Lys Leu Phe Ser Ser Gln Cys Gly
                645                 650                 655     
Lys Met Ala Asn Lys Ala Asn Thr Ser Gly Asp Phe Glu Lys Asp Asp
            660                 665                 670         
Asp Ala Cys Lys Thr Glu Asp Ser Asp Asp Ile His Phe Glu Pro Val
        675                 680                 685             
Val Gln Met Pro Glu Lys Val Glu Leu Val Thr Gly Glu Glu Gly Glu
    690                 695                 700                 
Lys Val Leu Tyr Ser Gln Gly Val Lys Leu Phe Arg Phe Asp Ala Glu
705                 710                 715                 720 
Ile Ser Gln Trp Lys Glu Arg Gly Leu Gly Asn Leu Lys Ile Leu Lys
                725                 730                 735     
Asn Glu Val Asn Gly Lys Pro Arg Met Leu Met Arg Arg Asp Gln Val
            740                 745                 750         
Leu Lys Val Cys Ala Asn His Trp Ile Thr Thr Thr Met Asn Leu Lys
        755                 760                 765             
Pro Leu Ser Gly Ser Asp Arg Ala Trp Met Trp Leu Ala Ser Asp Phe
    770                 775                 780                 
Ser Asp Gly Asp Ala Lys Leu Glu Arg Leu Ala Ala Gln Phe Lys Thr
785                 790                 795                 800 
Pro Glu Leu Ala Glu Glu Phe Lys Gln Lys Phe Glu Glu Cys Gln Arg
                805                 810                 815     
Leu Leu Leu Asp Ile Pro Leu Gln Thr Pro His Lys Leu Val Asp Thr
            820                 825                 830         
Gly Arg Ala Ala Lys Leu Ile Gln Arg Ala Glu Glu Met Lys Ser Gly
        835                 840                 845             
Leu Lys Asp Phe Lys Thr Phe Leu Thr Asn Asp Gln Thr Lys Val Thr
    850                 855                 860                 
Glu Glu Glu Asn Lys Gly Ser Gly Thr Gly Ala Ala Gly Ala Ser Asp
865                 870                 875                 880 
Thr Thr Ile Lys Pro Asn Pro Glu Asn Thr Gly Pro Thr Leu Glu Trp
                885                 890                 895     
Asp Asn Tyr Asp Leu Arg Glu Asp Ala Leu Asp Asp Asn Val Ser Ser
            900                 905                 910         
Ser Ser Val His Asp Ser Pro Leu Ala Ser Ser Pro Val Arg Lys Asn
        915                 920                 925             
Ile Phe Arg Phe Asp Glu Ser Thr Thr Gly Phe Asn Phe Ser Phe Lys
    930                 935                 940                 
Ser Ala Leu Ser Leu Ser Lys Ser Pro Ala Lys Leu Asn Gln Ser Gly
945                 950                 955                 960 
Thr Ser Val Gly Thr Asp Glu Glu Ser Asp Val Thr Gln Glu Glu Glu
                965                 970                 975     
Arg Asp Gly Gln Tyr Phe Glu Pro Val Val Pro Leu Pro Asp Leu Val
            980                 985                 990         
Glu Val Ser Ser Gly Glu Glu Asn Glu Gln Val Val Phe Ser His Met
        995                 1000                1005            
Ala Glu Leu Tyr Arg Tyr Asp Lys Asp Val Gly Gln Trp Lys Glu Arg
    1010                1015                1020                
Gly Ile Gly Asp Ile Lys Ile Leu Gln Asn Tyr Asp Asn Lys Gln Val
1025                1030                1035                1040
Arg Ile Val Met Arg Arg Asp Gln Val Leu Lys Leu Cys Ala Asn His
                1045                1050                1055    
Arg Ile Thr Pro Asp Met Ser Leu Gln Asn Met Lys Gly Thr Glu Arg
            1060                1065                1070        
Val Trp Val Trp Thr Ala Cys Asp Phe Ala Asp Gly Glu Arg Lys Val
        1075                1080                1085            
Glu His Leu Ala Val Arg Phe Lys Leu Gln Asp Val Ala Asp Ser Phe
    1090                1095                1100                
Lys Lys Ile Phe Asp Glu Ala Lys Thr Ala Gln Glu Lys Asp Ser Leu
1105                1110                1115                1120
Ile Thr Pro His Val Ser Arg Ser Ser Thr Pro Arg Glu Ser Pro Cys
                1125                1130                1135    
Gly Lys Ile Ala Val Ala Val Leu Glu Glu Thr Thr Arg Glu Arg Thr
            1140                1145                1150        
Asp Val Ile Gln Gly Asp Asp Val Ala Asp Ala Ala Ser Glu Val Glu
        1155                1160                1165            
Val Ser Ser Thr Ser Glu Thr Thr Thr Lys Ala Val Val Ser Pro Pro
    1170                1175                1180                
Lys Phe Val Phe Gly Ser Glu Ser Val Lys Arg Ile Phe Ser Ser Glu
1185                1190                1195                1200
Lys Ser Asn Pro Phe Ala Phe Gly Asn Ser Ser Ala Thr Gly Ser Leu
                1205                1210                1215    
Phe Gly Phe Ser Phe Asn Ala Pro Leu Lys Ser Asn Asp Ser Glu Thr
            1220                1225                1230        
Ser Ser Val Ala Gln Ser Gly Ser Glu Ser Lys Val Glu Pro Lys Lys
        1235                1240                1245            
Cys Glu Leu Ser Lys Asn Ser Asp Ile Glu Gln Ser Ser Asp Ser Lys
    1250                1255                1260                
Val Lys Asn Leu Ser Ala Ser Phe Pro Met Glu Glu Ser Ser Ile Asn
1265                1270                1275                1280
Tyr Thr Phe Lys Thr Pro Glu Lys Glu Pro Pro Leu Trp His Ala Glu
                1285                1290                1295    
Phe Thr Lys Glu Glu Leu Val Gln Lys Leu Ser Ser Thr Thr Lys Ser
            1300                1305                1310        
Ala Asp Gln Leu Asn Gly Leu Leu Arg Glu Thr Glu Ala Thr Ser Ala
        1315                1320                1325            
Val Leu Met Glu Gln Ile Lys Leu Leu Lys Ser Glu Ile Arg Arg Leu
    1330                1335                1340                
Glu Arg Asn Gln Glu Glu Ser Ala Ala Asn Val Glu His Leu Lys Asn
1345                1350                1355                1360
Val Leu Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser Glu Arg Glu Ser
                1365                1370                1375    
Leu Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser Pro Glu Glu Lys
            1380                1385                1390        
Gly Lys Leu Ala Ala Val Ala Gln Gly Leu Gln Glu Thr Ser Ile Pro
        1395                1400                1405            
Lys Lys Lys
    1410    


<210> 7077
<211> 2617
<212> PRT
<213> Homo sapiens

<400> 7077
Met Leu Thr Asp Ser Gly Gly Gly Gly Thr Ser Phe Glu Glu Asp Leu
 1               5                  10                  15      
Asp Ser Val Ala Pro Arg Ser Ala Pro Ala Gly Ala Ser Glu Pro Pro
            20                  25                  30          
Pro Pro Gly Gly Val Gly Leu Gly Ile Arg Thr Val Arg Leu Phe Gly
        35                  40                  45              
Glu Ala Gly Pro Ala Ser Gly Val Gly Ser Ser Gly Gly Gly Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Gly Gly Gly Asp Ala Ala Leu Asp Phe Lys Leu Ala
65                  70                  75                  80  
Ala Ala Val Leu Arg Thr Gly Gly Gly Gly Gly Ala Ser Gly Ser Asp
                85                  90                  95      
Glu Asp Glu Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Glu Asp
            100                 105                 110         
Leu Asp Asn Pro Val Leu Lys Thr Thr Ser Glu Ile Phe Leu Ser Ser
        115                 120                 125             
Thr Ala Glu Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala
    130                 135                 140                 
Arg Leu Glu Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr
145                 150                 155                 160 
Ala Asp Gly Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr
                165                 170                 175     
Ser Ser Val Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg
            180                 185                 190         
Met Lys Ala Glu Asn Ser His Asn Ala Gly Gln Val Asp Thr Arg Ser
        195                 200                 205             
Leu Ala Glu Ala Cys Ser Asp Gly Asp Val Asn Ala Val Arg Lys Leu
    210                 215                 220                 
Leu Asp Glu Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser
225                 230                 235                 240 
Leu Leu Cys Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val
                245                 250                 255     
Leu Leu Ala Met His Ala Asn Val Glu Asp Arg Gly Asn Lys Gly Asp
            260                 265                 270         
Ile Thr Pro Leu Met Ala Ala Ser Ser Gly Gly Tyr Leu Asp Ile Val
        275                 280                 285             
Lys Leu Leu Leu Leu His Asp Ala Asp Val Asn Ser Gln Ser Ala Thr
    290                 295                 300                 
Gly Asn Thr Ala Leu Thr Tyr Ala Cys Ala Gly Gly Phe Val Asp Ile
305                 310                 315                 320 
Val Lys Val Leu Leu Asn Glu Gly Ala Asn Ile Glu Asp His Asn Glu
                325                 330                 335     
Asn Gly His Thr Pro Leu Met Glu Ala Ala Ser Ala Gly His Val Glu
            340                 345                 350         
Val Ala Arg Val Leu Leu Asp His Gly Ala Gly Ile Asn Thr His Ser
        355                 360                 365             
Asn Glu Phe Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His
    370                 375                 380                 
Leu Asp Met Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His
385                 390                 395                 400 
Lys Thr Asp Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly
                405                 410                 415     
His Val Glu Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn
            420                 425                 430         
Met Pro Ala Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly
        435                 440                 445             
Gly His Val Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Asn Leu
    450                 455                 460                 
Glu Glu Val Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg
465                 470                 475                 480 
Glu Gly His Glu Glu Met Val Ala Leu Leu Leu Ala Gln Gly Ala Asn
                485                 490                 495     
Ile Asn Ala Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala
            500                 505                 510         
Cys Cys Gly Gly Phe Ser Glu Val Ala Asp Phe Leu Ile Lys Ala Gly
        515                 520                 525             
Ala Asp Ile Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ser Gln
    530                 535                 540                 
Glu Gly His Leu Glu Leu Val Lys Tyr Leu Leu Ala Ser Gly Ala Asn
545                 550                 555                 560 
Val His Ala Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys
                565                 570                 575     
Glu Asn Gly His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala
            580                 585                 590         
Asp Leu Glu His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala
        595                 600                 605             
Ala Arg Ala Gly His Leu Cys Thr Val Gln Phe Leu Ile Ser Lys Gly
    610                 615                 620                 
Ala Asn Val Asn Arg Ala Thr Ala Asn Asn Asp His Thr Val Val Ser
625                 630                 635                 640 
Leu Ala Cys Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala
                645                 650                 655     
His Gly Ala Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu
            660                 665                 670         
Ile Glu Ala Ala Lys Gly Gly His Thr Asn Val Val Ser Tyr Leu Leu
        675                 680                 685             
Asp Tyr Pro Asn Asn Val Leu Ser Val Pro Thr Thr Asp Val Ser Gln
    690                 695                 700                 
Leu Pro Pro Pro Ser Gln Asp Gln Ser Gln Val Pro Arg Val Pro Thr
705                 710                 715                 720 
His Thr Leu Ala Met Val Val Pro Pro Gln Glu Pro Asp Arg Thr Ser
                725                 730                 735     
Gln Glu Asn Ser Pro Ala Leu Leu Gly Val Gln Lys Gly Thr Ser Lys
            740                 745                 750         
Gln Lys Ser Ser Ser Leu Gln Val Ala Asp Gln Asp Leu Leu Pro Ser
        755                 760                 765             
Phe His Pro Tyr Gln Pro Leu Glu Cys Ile Val Glu Glu Thr Glu Gly
    770                 775                 780                 
Lys Leu Asn Glu Leu Gly Gln Arg Ile Ser Ala Ile Glu Lys Ala Gln
785                 790                 795                 800 
Leu Lys Ser Leu Glu Leu Ile Gln Gly Glu Pro Leu Asn Lys Asp Lys
                805                 810                 815     
Ile Glu Glu Leu Lys Lys Asn Arg Glu Glu Gln Val Gln Lys Lys Lys
            820                 825                 830         
Lys Ile Leu Lys Glu Leu Gln Lys Val Glu Arg Gln Leu Gln Met Lys
        835                 840                 845             
Thr Gln Gln Gln Phe Thr Lys Glu Tyr Leu Glu Thr Lys Gly Gln Lys
    850                 855                 860                 
Asp Thr Val Ser Leu His Gln Gln Cys Ser His Arg Gly Val Phe Pro
865                 870                 875                 880 
Glu Gly Glu Gly Asp Gly Ser Leu Pro Glu Asp His Phe Ser Glu Leu
                885                 890                 895     
Pro Gln Val Asp Thr Ile Leu Phe Lys Asp Asn Asp Val Asp Asp Glu
            900                 905                 910         
Gln Gln Ser Pro Pro Ser Ala Glu Gln Ile Asp Phe Val Pro Val Gln
        915                 920                 925             
Pro Leu Ser Ser Pro Gln Cys Asn Phe Ser Ser Asp Leu Gly Ser Asn
    930                 935                 940                 
Gly Thr Asn Ser Leu Glu Leu Gln Lys Val Ser Gly Asn Gln Gln Ile
945                 950                 955                 960 
Val Gly Gln Pro Gln Ile Ala Ile Thr Gly His Asp Gln Gly Leu Leu
                965                 970                 975     
Val Gln Glu Pro Asp Gly Leu Met Val Ala Thr Pro Ala Gln Thr Leu
            980                 985                 990         
Thr Asp Thr Leu Asp Asp Leu Ile Ala Ala Val Ser Thr Arg Val Pro
        995                 1000                1005            
Thr Gly Ser Asn Ser Ser Ser Gln Thr Thr Glu Cys Leu Thr Pro Glu
    1010                1015                1020                
Ser Cys Ser Gln Thr Thr Ser Asn Val Ala Ser Gln Ser Met Pro Pro
1025                1030                1035                1040
Val Tyr Pro Ser Val Asp Ile Asp Ala His Thr Glu Ser Asn His Asp
                1045                1050                1055    
Thr Ala Leu Thr Leu Ala Cys Ala Gly Gly His Glu Glu Leu Val Ser
            1060                1065                1070        
Val Leu Ile Ala Arg Asp Ala Lys Ile Glu His Arg Asp Lys Lys Gly
        1075                1080                1085            
Phe Thr Pro Leu Ile Leu Ala Ala Thr Ala Gly His Val Gly Val Val
    1090                1095                1100                
Glu Ile Leu Leu Asp Lys Gly Gly Asp Ile Glu Ala Gln Ser Glu Arg
1105                1110                1115                1120
Thr Lys Asp Thr Pro Leu Ser Leu Ala Cys Ser Gly Gly Arg Gln Glu
                1125                1130                1135    
Val Val Asp Leu Leu Leu Ala Arg Gly Ala Asn Lys Glu His Arg Asn
            1140                1145                1150        
Val Ser Asp Tyr Thr Pro Leu Ser Leu Ala Ala Ser Gly Gly Tyr Val
        1155                1160                1165            
Asn Ile Ile Lys Ile Leu Leu Asn Ala Gly Ala Glu Ile Asn Ser Arg
    1170                1175                1180                
Thr Gly Ser Lys Leu Gly Ile Ser Pro Leu Met Leu Ala Ala Met Asn
1185                1190                1195                1200
Gly His Val Pro Ala Val Lys Leu Leu Leu Asp Met Gly Ser Asp Ile
                1205                1210                1215    
Asn Ala Gln Ile Glu Thr Asn Arg Asn Thr Ala Leu Thr Leu Ala Cys
            1220                1225                1230        
Phe Gln Gly Arg Ala Glu Val Val Ser Leu Leu Leu Asp Arg Lys Ala
        1235                1240                1245            
Asn Val Glu His Arg Ala Lys Thr Gly Leu Thr Pro Leu Met Glu Ala
    1250                1255                1260                
Ala Ser Gly Gly Tyr Ala Glu Val Gly Arg Val Leu Leu Asp Lys Gly
1265                1270                1275                1280
Ala Asp Val Asn Ala Pro Pro Val Pro Ser Ser Arg Asp Thr Ala Leu
                1285                1290                1295    
Thr Ile Ala Ala Asp Lys Gly His Tyr Lys Phe Cys Glu Leu Leu Ile
            1300                1305                1310        
His Arg Gly Ala His Ile Asp Val Arg Asn Lys Lys Gly Asn Thr Pro
        1315                1320                1325            
Leu Trp Leu Ala Ser Asn Gly Gly His Phe Asp Val Val Gln Leu Leu
    1330                1335                1340                
Val Gln Ala Gly Ala Asp Val Asp Ala Ala Asp Asn Arg Lys Ile Thr
1345                1350                1355                1360
Pro Leu Met Ser Ala Phe Arg Lys Gly His Val Lys Val Val Gln Tyr
                1365                1370                1375    
Leu Val Lys Glu Val Asn Gln Phe Pro Ser Asp Ile Glu Cys Met Arg
            1380                1385                1390        
Tyr Ile Ala Thr Ile Thr Asp Lys Glu Leu Leu Lys Lys Cys His Gln
        1395                1400                1405            
Cys Val Glu Thr Ile Val Lys Ala Lys Asp Gln Gln Ala Ala Glu Ala
    1410                1415                1420                
Asn Lys Asn Ala Ser Ile Leu Leu Lys Glu Leu Asp Leu Glu Lys Ser
1425                1430                1435                1440
Arg Glu Glu Ser Arg Lys Gln Ala Leu Ala Ala Lys Arg Glu Lys Arg
                1445                1450                1455    
Lys Glu Lys Arg Lys Lys Lys Lys Glu Glu Gln Lys Arg Lys Gln Glu
            1460                1465                1470        
Glu Asp Glu Glu Asn Lys Pro Lys Glu Asn Ser Glu Leu Pro Glu Asp
        1475                1480                1485            
Glu Asp Glu Glu Glu Asn Asp Glu Asp Val Glu Gln Glu Val Pro Ile
    1490                1495                1500                
Glu Pro Pro Ser Ala Thr Thr Thr Thr Thr Ile Gly Ile Ser Ala Thr
1505                1510                1515                1520
Ser Ala Thr Phe Thr Asn Val Phe Gly Lys Lys Arg Ala Asn Val Val
                1525                1530                1535    
Thr Thr Pro Ser Thr Asn Arg Lys Asn Lys Lys Asn Lys Thr Lys Glu
            1540                1545                1550        
Thr Pro Pro Thr Ala His Leu Ile Leu Pro Glu Gln His Met Ser Leu
        1555                1560                1565            
Ala Gln Gln Lys Ala Asp Lys Asn Lys Ile Asn Gly Glu Pro Arg Gly
    1570                1575                1580                
Gly Gly Ala Gly Gly Asn Ser Asp Ser Asp Asn Leu Asp Ser Thr Asp
1585                1590                1595                1600
Cys Asn Ser Glu Ser Ser Ser Gly Gly Lys Ser Gln Glu Leu Asn Phe
                1605                1610                1615    
Val Met Asp Val Asn Ser Ser Lys Tyr Pro Ser Leu Leu Leu His Ser
            1620                1625                1630        
Gln Glu Glu Lys Thr Ser Thr Ala Thr Ser Lys Thr Gln Thr Arg Leu
        1635                1640                1645            
Glu Gly Glu Val Thr Pro Asn Ser Leu Ser Thr Ser Tyr Lys Thr Val
    1650                1655                1660                
Ser Leu Pro Leu Ser Ser Pro Asn Ile Lys Leu Asn Leu Thr Ser Pro
1665                1670                1675                1680
Lys Arg Gly Gln Lys Arg Glu Glu Gly Trp Lys Glu Val Val Arg Arg
                1685                1690                1695    
Ser Lys Lys Leu Ser Val Pro Ala Ser Val Val Ser Arg Ile Met Gly
            1700                1705                1710        
Arg Gly Gly Cys Asn Ile Thr Ala Ile Gln Asp Val Thr Gly Ala His
        1715                1720                1725            
Ile Asp Val Asp Lys Gln Lys Asp Lys Asn Gly Glu Arg Met Ile Thr
    1730                1735                1740                
Ile Arg Gly Gly Thr Glu Ser Thr Arg Tyr Ala Val Gln Leu Ile Asn
1745                1750                1755                1760
Ala Leu Ile Gln Asp Pro Ala Lys Glu Leu Glu Asp Leu Ile Pro Lys
                1765                1770                1775    
Asn His Ile Arg Thr Pro Ala Ser Thr Lys Ser Ile His Ala Asn Phe
            1780                1785                1790        
Ser Ser Gly Val Gly Thr Thr Ala Ala Ser Ser Lys Asn Ala Phe Pro
        1795                1800                1805            
Leu Gly Ala Pro Thr Leu Val Thr Ser Gln Ala Thr Thr Leu Ser Thr
    1810                1815                1820                
Phe Gln Pro Ala Asn Lys Leu Asn Lys Asn Val Pro Thr Asn Val Arg
1825                1830                1835                1840
Ser Ser Phe Pro Val Ser Leu Pro Leu Ala Tyr Pro His Pro His Phe
                1845                1850                1855    
Ala Leu Leu Ala Ala Gln Thr Met Gln Gln Ile Arg His Pro Arg Leu
            1860                1865                1870        
Pro Met Ala Gln Phe Gly Gly Thr Phe Ser Pro Ser Pro Asn Thr Trp
        1875                1880                1885            
Gly Pro Phe Pro Val Arg Pro Val Asn Pro Gly Asn Thr Asn Ser Ser
    1890                1895                1900                
Pro Lys His Asn Asn Thr Ser Arg Leu Pro Asn Gln Asn Gly Thr Val
1905                1910                1915                1920
Leu Pro Ser Glu Ser Ala Gly Leu Ala Thr Ala Ser Cys Pro Ile Thr
                1925                1930                1935    
Val Ser Ser Val Val Ala Ala Ser Gln Gln Leu Cys Val Thr Asn Thr
            1940                1945                1950        
Arg Thr Pro Ser Ser Val Arg Lys Gln Leu Phe Ala Cys Val Pro Lys
        1955                1960                1965            
Thr Ser Pro Pro Ala Thr Val Ile Ser Ser Val Thr Ser Thr Cys Ser
    1970                1975                1980                
Ser Leu Pro Ser Val Ser Ser Ala Pro Ile Thr Ser Gly Gln Ala Pro
1985                1990                1995                2000
Thr Thr Phe Leu Pro Ala Ser Thr Ser Gln Ala Gln Leu Ser Ser Gln
                2005                2010                2015    
Lys Met Glu Ser Phe Ser Ala Val Pro Pro Thr Lys Glu Lys Val Ser
            2020                2025                2030        
Thr Gln Asp Gln Pro Met Ala Asn Leu Cys Thr Pro Ser Ser Thr Ala
        2035                2040                2045            
Asn Ser Cys Ser Ser Ser Ala Ser Asn Thr Pro Gly Ala Pro Glu Thr
    2050                2055                2060                
His Pro Ser Ser Ser Pro Thr Pro Thr Ser Ser Asn Thr Gln Glu Glu
2065                2070                2075                2080
Ala Gln Pro Ser Ser Val Ser Asp Leu Ser Pro Met Ser Met Pro Phe
                2085                2090                2095    
Ala Ser Asn Ser Glu Pro Ala Pro Leu Thr Leu Thr Ser Pro Arg Met
            2100                2105                2110        
Val Ala Ala Asp Asn Gln Asp Thr Ser Asn Leu Pro Gln Leu Ala Val
        2115                2120                2125            
Pro Ala Pro Arg Val Ser His Arg Met Gln Pro Arg Gly Ser Phe Tyr
    2130                2135                2140                
Ser Met Val Pro Asn Ala Thr Ile His Gln Asp Pro Gln Ser Ile Phe
2145                2150                2155                2160
Val Thr Asn Pro Val Thr Leu Thr Pro Pro Gln Gly Pro Pro Ala Ala
                2165                2170                2175    
Val Gln Leu Ser Ser Ala Val Asn Ile Met Asn Gly Ser Gln Met His
            2180                2185                2190        
Ile Asn Pro Ala Asn Lys Ser Leu Pro Pro Thr Phe Gly Pro Ala Thr
        2195                2200                2205            
Leu Phe Asn His Phe Ser Ser Leu Phe Asp Ser Ser Gln Val Pro Ala
    2210                2215                2220                
Asn Gln Gly Trp Gly Asp Gly Pro Leu Ser Ser Arg Val Ala Thr Asp
2225                2230                2235                2240
Ala Ser Phe Thr Val Gln Ser Ala Phe Leu Gly Asn Ser Val Leu Gly
                2245                2250                2255    
His Leu Glu Asn Met His Pro Asp Asn Ser Lys Ala Pro Gly Phe Arg
            2260                2265                2270        
Pro Pro Ser Gln Arg Val Ser Thr Ser Pro Val Gly Leu Pro Ser Ile
        2275                2280                2285            
Asp Pro Ser Gly Ser Ser Pro Ser Ser Ser Ser Ala Pro Leu Ala Ser
    2290                2295                2300                
Phe Ser Gly Ile Pro Gly Thr Arg Val Phe Leu Gln Gly Pro Ala Pro
2305                2310                2315                2320
Val Gly Thr Pro Ser Phe Asn Arg Gln His Phe Ser Pro His Pro Trp
                2325                2330                2335    
Thr Ser Ala Ser Asn Ser Ser Thr Ser Ala Pro Pro Thr Leu Gly Gln
            2340                2345                2350        
Pro Lys Gly Val Ser Ala Ser Gln Asp Arg Lys Ile Pro Pro Pro Ile
        2355                2360                2365            
Gly Thr Glu Arg Leu Ala Arg Ile Arg Gln Gly Gly Ser Val Ala Gln
    2370                2375                2380                
Ala Pro Ala Gly Thr Ser Phe Val Ala Pro Val Gly His Ser Gly Ile
2385                2390                2395                2400
Trp Ser Phe Gly Val Asn Ala Val Ser Glu Gly Leu Ser Gly Trp Ser
                2405                2410                2415    
Gln Ser Val Met Gly Asn His Pro Met His Gln Gln Leu Ser Asp Pro
            2420                2425                2430        
Ser Thr Phe Ser Gln His Gln Pro Met Glu Arg Asp Asp Ser Gly Met
        2435                2440                2445            
Val Ala Pro Ser Asn Ile Phe His Gln Pro Met Ala Ser Gly Phe Val
    2450                2455                2460                
Asp Phe Ser Lys Gly Leu Pro Ile Ser Met Tyr Gly Gly Thr Ile Ile
2465                2470                2475                2480
Pro Ser His Pro Gln Leu Ala Asp Val Pro Gly Gly Pro Leu Phe Asn
                2485                2490                2495    
Gly Leu His Asn Pro Asp Pro Ala Trp Asn Pro Met Ile Lys Val Ile
            2500                2505                2510        
Gln Asn Ser Thr Glu Cys Thr Asp Ala Gln Gln Ala Ser Leu Leu Pro
        2515                2520                2525            
Ser Val Pro Ala Leu Lys Gly Glu Ile Pro Ser Pro Gln Leu Thr Arg
    2530                2535                2540                
Pro Lys Lys Arg Ile Gly Arg Pro Met Val Ala Ser Pro Asn Gln Arg
2545                2550                2555                2560
His Gln Asp His Leu Arg Pro Lys Val Pro Ala Gly Val Gln Glu Leu
                2565                2570                2575    
Thr His Cys Pro Asp Thr Pro Leu Leu Pro Pro Ser Asp Ser Arg Gly
            2580                2585                2590        
His Asn Ser Ser Asn Ser Pro Ser Leu Gln Ala Gly Gly Ala Glu Gly
        2595                2600                2605            
Ala Gly Asp Arg Gly Arg Asp Thr Arg
    2610                2615        


<210> 7078
<211> 655
<212> PRT
<213> Homo sapiens

<400> 7078
Met Pro Glu Asp Arg Asn Ser Gly Gly Cys Pro Ala Gly Ala Leu Ala
 1               5                  10                  15      
Ser Thr Pro Phe Ile Pro Lys Thr Thr Tyr Arg Arg Ile Lys Arg Cys
            20                  25                  30          
Phe Ser Phe Arg Lys Gly Ile Phe Gly Gln Lys Leu Glu Asp Thr Val
        35                  40                  45              
Arg Tyr Glu Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu
    50                  55                  60                  
Gln Cys Val Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu
65                  70                  75                  80  
Phe Arg Leu Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala
                85                  90                  95      
Phe Asp Cys Gly Glu Lys Pro Ser Phe Asp Ser Asn Thr Asp Val His
            100                 105                 110         
Thr Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro
        115                 120                 125             
Val Ile Pro Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu
    130                 135                 140                 
Leu Ser Lys Glu Glu Glu Ala Gly Val Lys Glu Leu Ala Lys Gln Val
145                 150                 155                 160 
Lys Ser Leu Pro Val Val Asn Tyr Asn Leu Leu Lys Tyr Ile Cys Arg
                165                 170                 175     
Phe Leu Asp Glu Val Gln Ser Tyr Ser Gly Val Asn Lys Met Ser Val
            180                 185                 190         
Gln Asn Leu Ala Thr Val Phe Gly Pro Asn Ile Leu Arg Pro Lys Val
        195                 200                 205             
Glu Asp Pro Leu Thr Ile Met Glu Gly Thr Val Val Val Gln Gln Leu
    210                 215                 220                 
Met Ser Val Met Ile Ser Lys His Asp Cys Leu Phe Pro Lys Asp Ala
225                 230                 235                 240 
Glu Leu Gln Ser Lys Pro Gln Asp Gly Val Ser Asn Asn Asn Glu Ile
                245                 250                 255     
Gln Lys Lys Ala Thr Met Gly Leu Leu Gln Asn Lys Glu Asn Asn Asn
            260                 265                 270         
Thr Lys Asp Ser Pro Ser Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser
        275                 280                 285             
Pro Gln Arg Ser Ser Met Asn Asn Gly Ser Pro Thr Ala Leu Ser Gly
    290                 295                 300                 
Ser Lys Thr Asn Ser Pro Lys Asn Ser Val His Lys Leu Asp Val Ser
305                 310                 315                 320 
Arg Ser Pro Pro Leu Met Val Lys Lys Asn Pro Ala Phe Asn Lys Gly
                325                 330                 335     
Ser Gly Ile Val Thr Asn Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly
            340                 345                 350         
Leu Glu Lys Thr Gln Thr Thr Pro Asn Gly Ser Leu Gln Ala Arg Arg
        355                 360                 365             
Ser Ser Ser Leu Lys Val Ser Gly Thr Lys Met Gly Thr His Ser Val
    370                 375                 380                 
Gln Asn Gly Thr Val Arg Met Gly Ile Leu Asn Ser Asp Thr Leu Gly
385                 390                 395                 400 
Asn Pro Thr Asn Val Arg Asn Met Ser Trp Leu Pro Asn Gly Tyr Val
                405                 410                 415     
Thr Leu Arg Asp Asn Lys Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln
            420                 425                 430         
His Asn Arg Leu Ser Thr Tyr Asp Asn Val His Gln Gln Phe Ser Met
        435                 440                 445             
Met Asn Leu Asp Asp Lys Gln Ser Ile Asp Ser Ala Thr Trp Ser Thr
    450                 455                 460                 
Ser Ser Cys Glu Ile Ser Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser
465                 470                 475                 480 
Ser Thr Thr Thr Cys Pro Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu
                485                 490                 495     
Asp Pro Val Leu Asp Gly Pro Pro Gln Asp Asp Leu Ser His Pro Arg
            500                 505                 510         
Asp Tyr Glu Ser Lys Ser Asp His Arg Ser Val Gly Gly Arg Ser Ser
        515                 520                 525             
Arg Ala Thr Ser Ser Ser Asp Asn Ser Glu Thr Phe Val Gly Asn Ser
    530                 535                 540                 
Ser Ser Asn His Ser Ala Leu His Ser Leu Val Ser Ser Leu Lys Gln
545                 550                 555                 560 
Glu Met Thr Lys Gln Lys Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu
                565                 570                 575     
Glu Gln Arg Asn Leu Thr Leu Glu Thr Glu Met Met Ser Leu His Asp
            580                 585                 590         
Glu Leu Asp Gln Glu Arg Lys Lys Phe Thr Met Ile Glu Ile Lys Met
        595                 600                 605             
Arg Asn Ala Glu Arg Ala Lys Glu Asp Ala Glu Lys Arg Asn Asp Met
    610                 615                 620                 
Leu Gln Lys Glu Met Glu Gln Phe Phe Ser Thr Phe Gly Glu Leu Thr
625                 630                 635                 640 
Val Glu Pro Arg Arg Thr Glu Arg Gly Asn Thr Ile Trp Ile Gln
                645                 650                 655 


<210> 7079
<211> 748
<212> PRT
<213> Homo sapiens

<400> 7079
Met Glu Glu Asn Asn Asp Ser Thr Glu Asn Pro Gln Gln Gly Gln Gly
 1               5                  10                  15      
Arg Gln Asn Ala Ile Lys Cys Gly Trp Leu Arg Lys Gln Gly Gly Phe
            20                  25                  30          
Val Lys Thr Trp His Thr Arg Trp Phe Val Leu Lys Gly Asp Gln Leu
        35                  40                  45              
Tyr Tyr Phe Lys Asp Glu Asp Glu Thr Lys Pro Leu Gly Thr Ile Phe
    50                  55                  60                  
Leu Pro Gly Asn Lys Val Ser Glu His Pro Cys Asn Glu Glu Asn Pro
65                  70                  75                  80  
Gly Lys Phe Leu Phe Glu Val Val Pro Gly Gly Asp Arg Asp Arg Met
                85                  90                  95      
Thr Ala Asn His Glu Ser Tyr Leu Leu Met Ala Ser Thr Gln Asn Asp
            100                 105                 110         
Met Glu Asp Trp Val Lys Ser Ile Arg Arg Val Ile Trp Gly Pro Phe
        115                 120                 125             
Gly Gly Gly Ile Phe Gly Gln Lys Leu Glu Asp Ala Val Arg Tyr Glu
    130                 135                 140                 
Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu Gln Cys Val
145                 150                 155                 160 
Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu Phe Arg Leu
                165                 170                 175     
Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala Phe Asp Cys
            180                 185                 190         
Gly Glu Lys Pro Ser Phe Asp Ser Asn Thr Asp Val His Thr Val Ala
        195                 200                 205             
Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro Val Ile Pro
    210                 215                 220                 
Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu Leu Ser Lys
225                 230                 235                 240 
Glu Glu Glu Ala Gly Val Lys Glu Leu Ala Lys Gln Val Lys Ser Leu
                245                 250                 255     
Pro Val Val Asn Tyr Asn Leu Leu Lys Tyr Ile Cys Arg Phe Leu Asp
            260                 265                 270         
Glu Val Gln Ser Tyr Ser Gly Val Asn Lys Met Ser Val Gln Asn Leu
        275                 280                 285             
Ala Thr Val Phe Gly Pro Asn Ile Leu Arg Pro Lys Val Glu Asp Pro
    290                 295                 300                 
Leu Thr Ile Met Glu Gly Thr Val Val Val Gln Gln Leu Met Ser Val
305                 310                 315                 320 
Met Ile Ser Lys His Asp Cys Leu Phe Pro Lys Asp Ala Glu Leu Gln
                325                 330                 335     
Ser Lys Pro Gln Asp Gly Val Ser Asn Asn Asn Glu Ile Gln Lys Lys
            340                 345                 350         
Ala Thr Met Gly Gln Leu Gln Asn Lys Glu Asn Asn Asn Thr Lys Asp
        355                 360                 365             
Ser Pro Ser Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser Pro Gln Arg
    370                 375                 380                 
Ser Ser Met Asn Asn Gly Ser Pro Thr Ala Leu Ser Gly Ser Lys Thr
385                 390                 395                 400 
Asn Ser Pro Lys Asn Ser Val His Lys Leu Asp Val Ser Arg Ser Pro
                405                 410                 415     
Pro Leu Met Val Lys Lys Asn Pro Ala Phe Asn Lys Gly Ser Gly Ile
            420                 425                 430         
Val Thr Asn Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly Leu Glu Lys
        435                 440                 445             
Thr Gln Thr Thr Pro Asn Gly Ser Leu Gln Ala Arg Arg Ser Ser Ser
    450                 455                 460                 
Leu Lys Val Ser Gly Thr Lys Met Gly Thr His Ser Val Gln Asn Gly
465                 470                 475                 480 
Thr Val Arg Met Gly Ile Leu Asn Ser Asp Thr Leu Gly Asn Pro Thr
                485                 490                 495     
Asn Val Arg Asn Met Ser Trp Leu Pro Asn Gly Tyr Val Thr Leu Arg
            500                 505                 510         
Asp Asn Lys Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln His Asn Arg
        515                 520                 525             
Leu Ser Thr Tyr Asp Asn Val His Gln Gln Phe Ser Met Met Asn Leu
    530                 535                 540                 
Asp Asp Lys Gln Ser Ile Asp Ser Ala Thr Trp Ser Thr Ser Ser Cys
545                 550                 555                 560 
Glu Ile Ser Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser Ser Thr Thr
                565                 570                 575     
Thr Cys Pro Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu Asp Pro Val
            580                 585                 590         
Leu Asp Gly Pro Pro Gln Asp Asp Leu Ser His Pro Arg Asp Tyr Glu
        595                 600                 605             
Ser Lys Ser Asp His Arg Ser Val Gly Gly Arg Ser Ser Arg Ala Thr
    610                 615                 620                 
Ser Ser Ser Asp Asn Ser Glu Thr Phe Val Gly Asn Ser Ser Ser Asn
625                 630                 635                 640 
His Ser Ala Leu His Ser Leu Val Ser Ser Leu Lys Gln Glu Met Thr
                645                 650                 655     
Lys Gln Lys Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu Glu Gln Arg
            660                 665                 670         
Asn Leu Thr Leu Glu Thr Glu Met Met Ser Leu His Asp Glu Leu Asp
        675                 680                 685             
Gln Glu Arg Lys Lys Phe Thr Met Ile Glu Ile Lys Met Arg Asn Ala
    690                 695                 700                 
Glu Arg Ala Lys Glu Asp Ala Glu Lys Arg Asn Asp Met Leu Gln Lys
705                 710                 715                 720 
Glu Val Glu Gln Phe Phe Ser Thr Phe Gly Glu Leu Thr Val Glu Pro
                725                 730                 735     
Arg Arg Thr Glu Arg Gly Asn Thr Ile Trp Ile Gln
            740                 745             


<210> 7080
<211> 473
<212> PRT
<213> Homo sapiens

<400> 7080
Met Ala Leu Lys Asp Thr Gly Ser Gly Gly Ser Thr Ile Leu Pro Ile
 1               5                  10                  15      
Ser Glu Met Val Ser Ser Ser Ser Ser Pro Gly Ala Ser Ala Ala Ala
            20                  25                  30          
Ala Pro Gly Pro Cys Ala Pro Ser Pro Phe Pro Glu Val Val Glu Leu
        35                  40                  45              
Asn Val Gly Gly Gln Val Tyr Val Thr Lys His Ser Thr Leu Leu Ser
    50                  55                  60                  
Val Pro Asp Ser Thr Leu Ala Ser Met Phe Ser Pro Ser Ser Pro Arg
65                  70                  75                  80  
Gly Gly Ala Arg Arg Arg Gly Glu Leu Pro Arg Asp Ser Arg Ala Arg
                85                  90                  95      
Phe Phe Ile Asp Arg Asp Gly Phe Leu Phe Arg Tyr Val Leu Asp Tyr
            100                 105                 110         
Leu Arg Asp Lys Gln Leu Ala Leu Pro Glu His Phe Pro Glu Lys Glu
        115                 120                 125             
Arg Leu Leu Arg Glu Ala Glu Tyr Phe Gln Leu Thr Asp Leu Val Lys
    130                 135                 140                 
Leu Leu Ser Pro Lys Val Thr Lys Gln Asn Ser Leu Asn Asp Glu Gly
145                 150                 155                 160 
Cys Gln Ser Asp Leu Glu Asp Asn Val Ser Gln Gly Ser Ser Asp Ala
                165                 170                 175     
Leu Leu Leu Arg Gly Ala Ala Ala Ala Val Pro Ser Gly Pro Gly Ala
            180                 185                 190         
His Gly Gly Gly Gly Gly Gly Gly Ala Gln Asp Lys Arg Ser Gly Phe
        195                 200                 205             
Leu Thr Leu Gly Tyr Arg Gly Ser Tyr Thr Thr Val Arg Asp Asn Gln
    210                 215                 220                 
Ala Asp Ala Lys Phe Arg Arg Val Ala Arg Ile Met Val Cys Gly Arg
225                 230                 235                 240 
Ile Ala Leu Ala Lys Glu Val Phe Gly Asp Thr Leu Asn Glu Ser Arg
                245                 250                 255     
Asp Pro Asp Arg Gln Pro Glu Lys Tyr Thr Ser Arg Phe Tyr Leu Lys
            260                 265                 270         
Phe Thr Tyr Leu Glu Gln Ala Phe Asp Arg Leu Ser Glu Ala Gly Phe
        275                 280                 285             
His Met Val Ala Cys Asn Ser Ser Gly Thr Ala Ala Phe Val Asn Gln
    290                 295                 300                 
Tyr Arg Asp Asp Lys Ile Trp Ser Ser Tyr Thr Glu Tyr Ile Phe Phe
305                 310                 315                 320 
Arg Pro Pro Gln Lys Ile Val Ser Pro Lys Gln Glu His Glu Asp Arg
                325                 330                 335     
Lys His Asp Lys Val Thr Asp Lys Gly Ser Glu Ser Gly Thr Ser Cys
            340                 345                 350         
Asn Glu Leu Ser Thr Ser Ser Cys Asp Ser His Ser Glu Ala Ser Thr
        355                 360                 365             
Pro Gln Asp Asn Pro Ser Ser Ala Gln Gln Ala Thr Ala His Gln Pro
    370                 375                 380                 
Asn Thr Leu Thr Leu Asp Arg Pro Ser Lys Lys Ala Pro Val Gln Trp
385                 390                 395                 400 
Ile Pro Pro Pro Asp Lys Arg Arg Asn Ser Glu Leu Phe Gln Thr Leu
                405                 410                 415     
Ile Ser Lys Ser Arg Glu Thr Asn Leu Ser Lys Lys Lys Val Cys Glu
            420                 425                 430         
Lys Leu Ser Val Glu Glu Glu Met Lys Lys Cys Ile Gln Asp Phe Lys
        435                 440                 445             
Lys Ile His Ile Pro Asp Tyr Phe Pro Glu Arg Lys Arg Gln Trp Gln
    450                 455                 460                 
Ser Glu Leu Leu Gln Lys Tyr Gly Leu
465                 470             


<210> 7081
<211> 1542
<212> PRT
<213> Homo sapiens

<400> 7081
Met Glu Pro Glu Glu Glu Asp Glu Leu Gly Ser Gly Arg Asp Val Asp
 1               5                  10                  15      
Ser Asn Ser Asn Ala Asp Ser Glu Lys Trp Val Ala Gly Asp Gly Leu
            20                  25                  30          
Glu Glu Gln Glu Phe Ser Ile Lys Glu Ala Asn Phe Thr Glu Gly Ser
        35                  40                  45              
Leu Lys Leu Lys Ile Gln Thr Thr Lys Arg Ala Lys Lys Pro Pro Lys
    50                  55                  60                  
Asn Leu Glu Asn Tyr Ile Cys Pro Pro Glu Ile Lys Ile Thr Ile Lys
65                  70                  75                  80  
Gln Ser Gly Asp Gln Lys Val Ser Arg Ala Gly Lys Asn Ser Lys Ala
                85                  90                  95      
Thr Lys Glu Glu Glu Arg Ser His Ser Lys Lys Lys Leu Leu Thr Ala
            100                 105                 110         
Ser Asp Leu Ala Ala Ser Asp Leu Lys Gly Phe Gln Pro Gln Ala Tyr
        115                 120                 125             
Glu Arg Pro Gln Lys His Ser Thr Leu His Tyr Asp Thr Gly Leu Pro
    130                 135                 140                 
Gln Asp Phe Thr Gly Asp Thr Leu Lys Pro Lys His Gln Gln Lys Ser
145                 150                 155                 160 
Ser Ser Gln Asn His Met Asp Trp Ser Thr Asn Ser Asp Ser Gly Pro
                165                 170                 175     
Val Thr Gln Asn Cys Phe Ile Ser Pro Glu Ser Gly Arg Glu Thr Ala
            180                 185                 190         
Ser Thr Ser Lys Ile Pro Ala Leu Glu Pro Val Ala Ser Phe Ala Lys
        195                 200                 205             
Ala Gln Gly Lys Lys Gly Ser Ala Gly Asn Thr Trp Ser Gln Leu Ser
    210                 215                 220                 
Asn Asn Asn Lys Asp Leu Leu Leu Gly Gly Val Ala Pro Ser Pro Ser
225                 230                 235                 240 
Ser His Ser Ser Pro Ala Pro Pro Ser Ser Ser Ala Glu Cys Asn Gly
                245                 250                 255     
Leu Gln Pro Leu Val Asp Gln Asp Gly Gly Gly Thr Lys Glu Pro Pro
            260                 265                 270         
Glu Pro Pro Thr Val Gly Ser Lys Lys Lys Ser Ser Lys Lys Asp Val
        275                 280                 285             
Ile Ser Gln Thr Ile Pro Asn Pro Asp Leu Asp Trp Val Lys Asn Ala
    290                 295                 300                 
Gln Lys Ala Phe Asp Asn Thr Glu Gly Lys Arg Glu Gly Tyr Ser Ala
305                 310                 315                 320 
Asp Ser Ala Gln Glu Ala Ser Pro Ala Arg Gln Asn Val Ser Ser Ala
                325                 330                 335     
Ser Asn Pro Glu Asn Asp Ser Ser His Val Arg Ile Thr Ile Pro Ile
            340                 345                 350         
Lys Ala Pro Ser Leu Asp Pro Thr Asn His Lys Arg Lys Lys Arg Gln
        355                 360                 365             
Ser Ile Lys Ala Val Val Glu Lys Ile Met Pro Glu Lys Ala Leu Ala
    370                 375                 380                 
Ser Gly Ile Thr Met Ser Ser Glu Val Val Asn Arg Ile Leu Ser Asn
385                 390                 395                 400 
Ser Glu Gly Asn Lys Lys Asp Pro Arg Val Pro Lys Leu Ser Lys Met
                405                 410                 415     
Ile Glu Asn Glu Ser Pro Ser Val Gly Leu Glu Thr Gly Gly Asn Ala
            420                 425                 430         
Glu Lys Val Ile Pro Gly Gly Val Ser Lys Pro Arg Lys Pro Pro Met
        435                 440                 445             
Val Met Thr Pro Pro Thr Cys Thr Asp His Ser Pro Ser Arg Lys Leu
    450                 455                 460                 
Pro Glu Ile Gln His Pro Lys Phe Ala Ala Lys Arg Arg Trp Thr Cys
465                 470                 475                 480 
Ser Lys Pro Lys Pro Ser Thr Met Leu Arg Glu Ala Val Met Ala Thr
                485                 490                 495     
Ser Asp Lys Leu Met Leu Glu Pro Pro Ser Ala Tyr Pro Ile Thr Pro
            500                 505                 510         
Ser Ser Pro Leu Tyr Thr Asn Thr Asp Ser Leu Thr Val Ile Thr Pro
        515                 520                 525             
Val Lys Lys Lys Arg Gly Arg Pro Lys Lys Gln Pro Leu Leu Thr Val
    530                 535                 540                 
Glu Thr Ile His Glu Gly Thr Ser Thr Ser Pro Val Ser Pro Ile Ser
545                 550                 555                 560 
Arg Glu Phe Pro Gly Thr Lys Lys Arg Lys Arg Arg Arg Asn Leu Ala
                565                 570                 575     
Lys Leu Ala Gln Leu Val Pro Gly Glu Asp Lys Pro Met Ser Glu Met
            580                 585                 590         
Lys Phe His Lys Lys Val Gly Lys Leu Gly Val Leu Asp Lys Lys Thr
        595                 600                 605             
Ile Lys Thr Ile Asn Lys Met Lys Thr Leu Lys Arg Lys Asn Ile Leu
    610                 615                 620                 
Asn Gln Ile Leu Ser Cys Ser Ser Ser Val Ala Leu Lys Ala Lys Ala
625                 630                 635                 640 
Pro Pro Glu Thr Ser Pro Gly Ala Ala Ala Ile Glu Ser Lys Leu Gly
                645                 650                 655     
Lys Gln Ile Asn Val Ser Lys Arg Gly Thr Ile Tyr Ile Gly Lys Lys
            660                 665                 670         
Arg Gly Arg Lys Pro Arg Ala Glu Leu Pro Pro Pro Ser Glu Glu Pro
        675                 680                 685             
Lys Thr Ala Ile Lys His Pro Arg Pro Val Ser Ser Gln Pro Asp Val
    690                 695                 700                 
Pro Ala Val Pro Ser Asn Phe Gln Ser Leu Val Ala Ser Ser Pro Ala
705                 710                 715                 720 
Ala Met His Pro Leu Ser Thr Gln Leu Gly Gly Ser Asn Gly Asn Leu
                725                 730                 735     
Ser Pro Ala Ser Thr Glu Thr Asn Phe Ser Glu Leu Lys Thr Met Pro
            740                 745                 750         
Asn Leu Gln Pro Ile Ser Ala Leu Pro Thr Lys Thr Gln Lys Gly Ile
        755                 760                 765             
His Ser Gly Thr Trp Lys Leu Ser Pro Pro Arg Leu Met Ala Asn Ser
    770                 775                 780                 
Pro Ser His Leu Cys Glu Ile Gly Ser Leu Lys Glu Ile Thr Leu Ser
785                 790                 795                 800 
Pro Val Ser Glu Ser His Ser Glu Glu Thr Ile Pro Ser Asp Ser Gly
                805                 810                 815     
Ile Gly Thr Asp Asn Asn Ser Thr Ser Asp Gln Ala Glu Lys Ser Ser
            820                 825                 830         
Glu Ser Arg Arg Arg Tyr Ser Phe Asp Phe Cys Ser Leu Asp Asn Pro
        835                 840                 845             
Glu Ala Ile Pro Ser Asp Thr Ser Thr Lys Asn Arg His Gly His Arg
    850                 855                 860                 
Gln Lys His Leu Ile Val Asp Asn Phe Leu Ala His Glu Ser Leu Lys
865                 870                 875                 880 
Lys Pro Lys His Lys Arg Lys Arg Lys Ser Leu Gln Asn Arg Asp Asp
                885                 890                 895     
Leu Gln Phe Leu Ala Asp Leu Glu Glu Leu Ile Thr Lys Phe Gln Val
            900                 905                 910         
Phe Arg Ile Ser His Arg Ser Tyr Thr Phe Tyr His Glu Asn Pro Tyr
        915                 920                 925             
Pro Ser Ile Phe Arg Ile Asn Phe Asp His Tyr Tyr Pro Val Pro Tyr
    930                 935                 940                 
Ile Gln Tyr Asp Pro Leu Leu Tyr Leu Arg Arg Thr Ser Asp Leu Lys
945                 950                 955                 960 
Ser Lys Lys Lys Arg Gly Arg Pro Ala Lys Thr Asn Asp Thr Met Thr
                965                 970                 975     
Lys Val Pro Phe Leu Gln Gly Phe Ser Tyr Pro Ile Pro Ser Gly Ser
            980                 985                 990         
Tyr Tyr Ala Pro Tyr Gly Met Pro Tyr Thr Ser Met Pro Met Met Asn
        995                 1000                1005            
Leu Gly Tyr Tyr Gly Gln Tyr Pro Ala Pro Leu Tyr Leu Ser His Thr
    1010                1015                1020                
Leu Gly Ala Ala Ser Pro Phe Met Arg Pro Thr Val Pro Pro Pro Gln
1025                1030                1035                1040
Phe His Thr Asn Ser His Ile Lys Met Ser Gly Ala Ala Lys His Lys
                1045                1050                1055    
Ala Lys His Gly Val His Leu Gln Gly Pro Val Ser Met Gly Leu Gly
            1060                1065                1070        
Asp Met Gln Pro Ser Leu Asn Pro Pro Lys Val Gly Ser Ala Ser Leu
        1075                1080                1085            
Ser Ser Gly Arg Leu His Lys Arg Lys His Lys His Lys His Lys His
    1090                1095                1100                
Lys Glu Asp Arg Ile Leu Gly Thr His Asp Asn Leu Ser Gly Leu Phe
1105                1110                1115                1120
Ala Gly Lys Ala Thr Gly Phe Ser Ser His Ile Leu Ser Glu Arg Leu
                1125                1130                1135    
Ser Ser Ala Asp Lys Glu Leu Pro Leu Val Ser Glu Lys Asn Lys His
            1140                1145                1150        
Lys Glu Lys Gln Lys His Gln His Ser Glu Ala Gly His Lys Ala Ser
        1155                1160                1165            
Lys Asn Asn Phe Glu Val Asp Thr Leu Ser Thr Leu Ser Leu Ser Asp
    1170                1175                1180                
Ala Gln His Trp Thr Gln Ala Lys Glu Lys Gly Asp Leu Ser Ser Glu
1185                1190                1195                1200
Pro Val Asp Ser Cys Thr Lys Arg Tyr Ser Gly Ser Gly Gly Asp Gly
                1205                1210                1215    
Gly Ser Thr Arg Ser Glu Asn Leu Asp Val Phe Ser Glu Met Asn Pro
            1220                1225                1230        
Ser Asn Asp Lys Trp Asp Ser Asp Val Ser Gly Ser Lys Arg Arg Ser
        1235                1240                1245            
Tyr Glu Gly Phe Gly Thr Tyr Arg Glu Lys Asp Ile Gln Ala Phe Lys
    1250                1255                1260                
Met Asn Arg Lys Glu Arg Ser Ser Tyr Asp Ser Ser Met Ser Pro Gly
1265                1270                1275                1280
Met Pro Ser Pro His Leu Lys Val Asp Gln Thr Ala Val His Ser Lys
                1285                1290                1295    
Asn Glu Gly Ser Val Pro Thr Met Met Thr Arg Lys Lys Pro Ala Ala
            1300                1305                1310        
Val Asp Ser Val Thr Ile Pro Pro Ala Pro Val Leu Ser Leu Leu Ala
        1315                1320                1325            
Ala Ser Ala Ala Thr Ser Asp Ala Val Gly Ser Ser Leu Lys Lys Arg
    1330                1335                1340                
Phe Lys Arg Arg Glu Ile Glu Ala Ile Gln Cys Glu Val Arg Lys Met
1345                1350                1355                1360
Cys Asn Tyr Thr Lys Ile Leu Ser Thr Lys Lys Asn Leu Asp His Val
                1365                1370                1375    
Asn Lys Ile Leu Lys Ala Lys Arg Leu Gln Arg Gln Ser Lys Thr Gly
            1380                1385                1390        
Asn Asn Phe Val Lys Lys Arg Arg Gly Arg Pro Arg Lys Gln Pro Thr
        1395                1400                1405            
Gln Phe Asp Glu Asp Ser Arg Asp Gln Met Pro Val Leu Glu Lys Cys
    1410                1415                1420                
Ile Asp Leu Pro Ser Lys Arg Gly Gln Lys Pro Ser Leu Ser Pro Leu
1425                1430                1435                1440
Val Leu Glu Pro Ala Ala Ser Gln Asp Thr Ile Met Ala Thr Ile Glu
                1445                1450                1455    
Ala Val Ile His Met Ala Arg Glu Ala Pro Pro Leu Pro Pro Pro Pro
            1460                1465                1470        
Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro
        1475                1480                1485            
Pro Leu Pro Lys Thr Pro Arg Gly Gly Lys Arg Lys His Lys Pro Gln
    1490                1495                1500                
Ala Pro Ala Gln Pro Pro Gln Gln Ser Pro Pro Gln Gln Pro Leu Pro
1505                1510                1515                1520
Gln Glu Glu Glu Val Lys Ala Lys Arg Gln Arg Lys Ser Arg Gly Ser
                1525                1530                1535    
Glu Ser Glu Val Leu Pro
            1540        


<210> 7082
<211> 2144
<212> PRT
<213> Homo sapiens

<400> 7082
Met Thr Ser Leu Ala Gln Gln Leu Gln Arg Leu Ala Leu Pro Gln Ser
 1               5                  10                  15      
Asp Ala Ser Leu Leu Ser Arg Asp Glu Val Ala Ser Leu Leu Phe Asp
            20                  25                  30          
Pro Lys Glu Ala Ala Thr Ile Asp Arg Asp Thr Ala Phe Ala Ile Gly
        35                  40                  45              
Cys Thr Gly Leu Glu Glu Leu Leu Gly Ile Asp Pro Ser Phe Glu Gln
    50                  55                  60                  
Phe Glu Ala Pro Leu Phe Ser Gln Leu Ala Lys Thr Leu Glu Arg Ser
65                  70                  75                  80  
Val Gln Thr Lys Ala Val Asn Lys Gln Leu Asp Glu Asn Ile Ser Leu
                85                  90                  95      
Phe Leu Ile His Leu Ser Pro Tyr Phe Leu Leu Lys Pro Ala Gln Lys
            100                 105                 110         
Cys Leu Glu Trp Leu Ile His Arg Phe His Ile His Leu Tyr Asn Gln
        115                 120                 125             
Asp Ser Leu Ile Ala Cys Val Leu Pro Tyr His Glu Thr Arg Ile Phe
    130                 135                 140                 
Val Arg Val Ile Gln Leu Leu Lys Ile Asn Asn Ser Lys His Arg Trp
145                 150                 155                 160 
Phe Trp Leu Leu Pro Val Lys Gln Ser Gly Val Pro Leu Ala Lys Gly
                165                 170                 175     
Thr Leu Ile Thr His Cys Tyr Lys Asp Leu Gly Phe Met Asp Phe Ile
            180                 185                 190         
Cys Ser Leu Val Thr Lys Ser Val Lys Val Phe Ala Glu Tyr Pro Gly
        195                 200                 205             
Ser Ser Ala Gln Leu Arg Val Leu Leu Ala Phe Tyr Ala Ser Thr Ile
    210                 215                 220                 
Val Ser Ala Leu Val Ala Ala Glu Asp Val Ser Asp Asn Ile Ile Ala
225                 230                 235                 240 
Lys Leu Phe Pro Tyr Ile Gln Lys Gly Leu Lys Ser Ser Leu Pro Asp
                245                 250                 255     
Tyr Arg Ala Ala Thr Tyr Met Ile Ile Cys Gln Ile Ser Val Lys Val
            260                 265                 270         
Thr Met Glu Asn Thr Phe Val Asn Ser Leu Ala Ser Gln Ile Ile Lys
        275                 280                 285             
Thr Leu Thr Lys Ile Pro Ser Leu Ile Lys Asp Gly Leu Ser Cys Leu
    290                 295                 300                 
Ile Val Leu Leu Gln Arg Gln Lys Pro Glu Ser Leu Gly Lys Lys Pro
305                 310                 315                 320 
Phe Pro His Leu Cys Asn Val Pro Asp Leu Ile Thr Ile Leu His Gly
                325                 330                 335     
Ile Ser Glu Thr Tyr Asp Val Ser Pro Leu Leu Arg Tyr Met Leu Pro
            340                 345                 350         
His Leu Val Val Ser Ile Ile His His Val Thr Gly Glu Glu Thr Glu
        355                 360                 365             
Gly Met Asp Gly Gln Ile Tyr Lys Arg His Leu Glu Ala Ile Leu Thr
    370                 375                 380                 
Lys Ile Ser Leu Lys Asn Asn Leu Asp His Leu Leu Ala Ser Leu Leu
385                 390                 395                 400 
Phe Glu Glu Tyr Ile Ser Tyr Ser Ser Gln Glu Glu Met Asp Ser Asn
                405                 410                 415     
Lys Val Ser Leu Leu Asn Glu Gln Phe Leu Pro Leu Ile Arg Leu Leu
            420                 425                 430         
Glu Ser Lys Tyr Pro Arg Thr Leu Asp Val Val Leu Glu Glu His Leu
        435                 440                 445             
Lys Glu Ile Ala Asp Leu Lys Lys Gln Glu Leu Phe His Gln Phe Val
    450                 455                 460                 
Ser Leu Ser Thr Ser Gly Gly Lys Tyr Gln Phe Leu Ala Asp Ser Asp
465                 470                 475                 480 
Thr Ser Leu Met Leu Ser Leu Asn His Pro Leu Ala Pro Val Arg Ile
                485                 490                 495     
Leu Ala Met Asn His Leu Lys Lys Ile Met Lys Thr Ser Lys Glu Gly
            500                 505                 510         
Val Asp Glu Ser Phe Ile Lys Glu Ala Val Leu Ala Arg Leu Gly Asp
        515                 520                 525             
Asp Asn Ile Asp Val Val Leu Ser Ala Ile Ser Ala Phe Glu Ile Phe
    530                 535                 540                 
Lys Glu His Phe Ser Ser Glu Val Thr Ile Ser Asn Leu Leu Asn Leu
545                 550                 555                 560 
Phe Gln Arg Ala Glu Leu Ser Lys Asn Gly Glu Trp Tyr Glu Val Leu
                565                 570                 575     
Lys Ile Ala Ala Asp Ile Leu Ile Lys Glu Glu Ile Leu Ser Glu Asn
            580                 585                 590         
Asp Gln Leu Ser Asn Gln Val Val Val Cys Leu Leu Pro Phe Val Val
        595                 600                 605             
Ile Asn Asn Asp Asp Thr Glu Ser Ala Glu Met Lys Ile Ala Ile Tyr
    610                 615                 620                 
Leu Ser Lys Ser Gly Ile Cys Ser Leu His Pro Leu Leu Arg Gly Trp
625                 630                 635                 640 
Glu Glu Ala Leu Glu Asn Val Ile Lys Ser Thr Lys Pro Gly Lys Leu
                645                 650                 655     
Ile Gly Val Ala Asn Gln Lys Met Ile Glu Leu Leu Ala Asp Asn Ile
            660                 665                 670         
Asn Leu Gly Asp Pro Ser Ser Met Leu Lys Met Val Glu Asp Leu Ile
        675                 680                 685             
Ser Val Gly Glu Glu Glu Ser Phe Asn Leu Lys Gln Lys Val Thr Phe
    690                 695                 700                 
His Val Ile Leu Ser Val Leu Val Ser Cys Cys Ser Ser Leu Lys Glu
705                 710                 715                 720 
Thr His Phe Pro Phe Ala Ile Arg Val Phe Ser Leu Leu Gln Lys Lys
                725                 730                 735     
Ile Lys Lys Leu Glu Ser Val Ile Thr Ala Val Glu Ile Pro Ser Glu
            740                 745                 750         
Trp His Ile Glu Leu Met Leu Asp Arg Gly Ile Pro Val Glu Leu Trp
        755                 760                 765             
Ala His Tyr Val Glu Glu Leu Asn Ser Thr Gln Arg Val Ala Val Glu
    770                 775                 780                 
Asp Ser Val Phe Leu Val Phe Ser Leu Lys Lys Phe Ile Tyr Ala Leu
785                 790                 795                 800 
Lys Ala Pro Lys Ser Phe Pro Lys Gly Asp Ile Trp Trp Asn Pro Glu
                805                 810                 815     
Gln Leu Lys Glu Asp Ser Arg Asp Tyr Leu His Leu Leu Ile Gly Leu
            820                 825                 830         
Phe Glu Met Met Leu Asn Gly Ala Asp Ala Val His Phe Arg Val Leu
        835                 840                 845             
Met Lys Leu Phe Ile Lys Val His Leu Glu Asp Val Phe Gln Leu Phe
    850                 855                 860                 
Lys Phe Cys Ser Val Leu Trp Thr Tyr Gly Ser Ser Leu Ser Asn Pro
865                 870                 875                 880 
Leu Asn Cys Ser Val Lys Thr Val Leu Gln Thr Gln Ala Leu Tyr Val
                885                 890                 895     
Gly Cys Ala Met Leu Ser Ser Gln Lys Thr Gln Cys Lys His Gln Leu
            900                 905                 910         
Ala Ser Ile Ser Ser Pro Val Val Thr Ser Leu Leu Ile Asn Leu Gly
        915                 920                 925             
Ser Pro Val Lys Glu Val Arg Arg Ala Ala Ile Gln Cys Leu Gln Ala
    930                 935                 940                 
Leu Ser Gly Val Ala Ser Pro Phe Tyr Leu Ile Ile Asp His Leu Ile
945                 950                 955                 960 
Ser Lys Ala Glu Glu Ile Thr Ser Asp Ala Ala Tyr Val Ile Gln Asp
                965                 970                 975     
Leu Ala Thr Leu Phe Glu Glu Leu Gln Arg Glu Lys Lys Leu Lys Ser
            980                 985                 990         
His Gln Lys Leu Ser Glu Thr Leu Lys Asn Leu Leu Ser Cys Val Tyr
        995                 1000                1005            
Ser Cys Pro Ser Tyr Ile Ala Lys Asp Leu Met Lys Val Leu Gln Gly
    1010                1015                1020                
Val Asn Gly Glu Met Val Leu Ser Gln Leu Leu Pro Met Ala Glu Gln
1025                1030                1035                1040
Leu Leu Glu Lys Ile Gln Lys Glu Pro Thr Ala Val Leu Lys Asp Glu
                1045                1050                1055    
Ala Met Val Leu His Leu Thr Leu Gly Lys Tyr Asn Glu Phe Ser Val
            1060                1065                1070        
Ser Leu Leu Asn Glu Asp Pro Lys Ser Leu Asp Ile Phe Ile Lys Ala
        1075                1080                1085            
Val His Thr Thr Lys Glu Leu Tyr Ala Gly Met Pro Thr Ile Gln Ile
    1090                1095                1100                
Thr Ala Leu Glu Lys Ile Thr Lys Pro Phe Phe Ala Ala Ile Ser Asp
1105                1110                1115                1120
Glu Lys Val Gln Gln Lys Leu Leu Arg Met Leu Phe Asp Leu Leu Val
                1125                1130                1135    
Asn Cys Lys Asn Ser His Cys Ala Gln Thr Val Ser Ser Val Phe Lys
            1140                1145                1150        
Gly Ile Ser Val Asn Ala Glu Gln Val Arg Ile Glu Leu Glu Pro Pro
        1155                1160                1165            
Asp Lys Ala Lys Pro Leu Gly Thr Val Gln Gln Lys Arg Arg Gln Lys
    1170                1175                1180                
Met Gln Gln Lys Lys Ser Gln Asp Leu Glu Ser Val Gln Glu Val Gly
1185                1190                1195                1200
Gly Ser Tyr Trp Gln Arg Val Thr Leu Ile Leu Glu Leu Leu Gln His
                1205                1210                1215    
Lys Lys Lys Leu Arg Ser Pro Gln Ile Leu Val Pro Thr Leu Phe Asn
            1220                1225                1230        
Leu Leu Ser Arg Cys Leu Glu Pro Leu Pro Gln Glu Gln Gly Asn Met
        1235                1240                1245            
Glu Tyr Thr Lys Gln Leu Ile Leu Ser Cys Leu Leu Asn Ile Cys Gln
    1250                1255                1260                
Lys Leu Ser Pro Asp Gly Gly Lys Ile Pro Lys Asp Ile Leu Asp Glu
1265                1270                1275                1280
Glu Lys Phe Asn Val Glu Leu Ile Val Gln Cys Ile Arg Leu Ser Glu
                1285                1290                1295    
Met Pro Gln Thr His His His Ala Leu Leu Leu Leu Gly Thr Val Ala
            1300                1305                1310        
Gly Ile Phe Pro Asp Lys Val Leu His Asn Ile Met Ser Ile Phe Thr
        1315                1320                1325            
Phe Met Gly Ala Asn Val Met Arg Leu Asp Asp Thr Tyr Ser Phe Gln
    1330                1335                1340                
Val Ile Asn Lys Thr Val Lys Met Val Ile Pro Ala Leu Ile Gln Ser
1345                1350                1355                1360
Asp Ser Gly Asp Ser Ile Glu Val Ser Arg Asn Val Glu Glu Ile Val
                1365                1370                1375    
Val Lys Ile Ile Ser Val Phe Val Asp Ala Leu Pro His Val Pro Glu
            1380                1385                1390        
His Arg Arg Leu Pro Ile Leu Val Gln Leu Val Asp Thr Leu Gly Ala
        1395                1400                1405            
Glu Lys Phe Leu Trp Ile Leu Leu Ile Leu Leu Phe Glu Gln Tyr Val
    1410                1415                1420                
Thr Lys Thr Val Leu Ala Ala Ala Tyr Gly Glu Lys Asp Ala Ile Leu
1425                1430                1435                1440
Glu Ala Asp Thr Glu Phe Trp Phe Ser Val Cys Cys Glu Phe Ser Val
                1445                1450                1455    
Gln His Gln Ile Gln Ser Leu Met Asn Ile Leu Gln Tyr Leu Leu Lys
            1460                1465                1470        
Leu Pro Glu Glu Lys Glu Glu Thr Ile Pro Lys Ala Val Ser Phe Asn
        1475                1480                1485            
Lys Ser Glu Ser Gln Glu Glu Met Leu Gln Val Phe Asn Val Glu Thr
    1490                1495                1500                
His Thr Ser Lys Gln Leu Arg His Phe Lys Phe Leu Ser Val Ser Phe
1505                1510                1515                1520
Met Ser Gln Leu Leu Ser Ser Asn Asn Phe Leu Lys Lys Val Val Glu
                1525                1530                1535    
Ser Gly Gly Pro Glu Ile Leu Lys Gly Leu Glu Glu Arg Leu Leu Glu
            1540                1545                1550        
Thr Val Leu Gly Tyr Ile Ser Ala Val Ala Gln Ser Met Glu Arg Asn
        1555                1560                1565            
Ala Asp Lys Leu Thr Val Lys Phe Trp Arg Ala Leu Leu Ser Lys Ala
    1570                1575                1580                
Tyr Asp Leu Leu Asp Lys Val Asn Ala Leu Leu Pro Thr Glu Thr Phe
1585                1590                1595                1600
Ile Pro Val Ile Arg Gly Leu Val Gly Asn Pro Leu Pro Ser Val Arg
                1605                1610                1615    
Arg Lys Ala Leu Asp Leu Leu Asn Asn Lys Leu Gln Gln Asn Ile Ser
            1620                1625                1630        
Trp Lys Lys Thr Ile Val Thr Arg Phe Leu Lys Leu Val Pro Asp Leu
        1635                1640                1645            
Leu Ala Ile Val Gln Arg Lys Lys Lys Glu Gly Glu Glu Glu Gln Ala
    1650                1655                1660                
Ile Asn Arg Gln Thr Ala Leu Tyr Thr Leu Lys Leu Leu Cys Lys Asn
1665                1670                1675                1680
Phe Gly Ala Glu Asn Pro Asp Pro Phe Val Pro Val Leu Asn Thr Ala
                1685                1690                1695    
Val Lys Leu Ile Ala Pro Glu Arg Lys Glu Glu Lys Asn Val Leu Gly
            1700                1705                1710        
Ser Ala Leu Leu Cys Ile Ala Glu Val Thr Ser Thr Leu Glu Ala Leu
        1715                1720                1725            
Ala Ile Pro Gln Leu Pro Ser Leu Met Pro Ser Leu Leu Thr Thr Met
    1730                1735                1740                
Lys Asn Thr Ser Glu Leu Val Ser Ser Glu Val Tyr Leu Leu Ser Ala
1745                1750                1755                1760
Leu Ala Ala Leu Gln Lys Val Val Glu Thr Leu Pro His Phe Ile Ser
                1765                1770                1775    
Pro Tyr Leu Glu Gly Ile Leu Ser Gln Val Ile His Leu Glu Lys Ile
            1780                1785                1790        
Thr Ser Glu Met Gly Ser Ala Ser Gln Ala Asn Ile Arg Leu Thr Ser
        1795                1800                1805            
Leu Lys Lys Thr Leu Ala Thr Thr Leu Ala Pro Arg Val Leu Leu Pro
    1810                1815                1820                
Ala Ile Lys Lys Thr Tyr Lys Gln Ile Glu Lys Asn Trp Lys Asn His
1825                1830                1835                1840
Met Gly Pro Phe Met Ser Ile Leu Gln Glu His Ile Gly Val Met Lys
                1845                1850                1855    
Lys Glu Glu Leu Thr Ser His Gln Ser Gln Leu Thr Ala Phe Phe Leu
            1860                1865                1870        
Glu Ala Leu Asp Phe Arg Ala Gln His Ser Glu Asn Asp Leu Glu Glu
        1875                1880                1885            
Val Gly Lys Thr Glu Asn Cys Ile Ile Asp Cys Leu Val Ala Met Val
    1890                1895                1900                
Val Lys Leu Ser Glu Val Thr Phe Arg Pro Leu Phe Phe Lys Leu Phe
1905                1910                1915                1920
Asp Trp Ala Lys Thr Glu Asp Ala Pro Lys Asp Arg Leu Leu Thr Phe
                1925                1930                1935    
Tyr Asn Leu Ala Asp Cys Ile Ala Glu Lys Leu Lys Gly Leu Phe Thr
            1940                1945                1950        
Leu Phe Ala Gly His Leu Val Lys Pro Phe Ala Asp Thr Leu Asn Gln
        1955                1960                1965            
Val Asn Ile Ser Lys Thr Asp Glu Ala Phe Phe Asp Ser Glu Asn Asp
    1970                1975                1980                
Pro Glu Lys Cys Cys Leu Leu Leu Gln Phe Ile Leu Asn Cys Leu Tyr
1985                1990                1995                2000
Lys Ile Phe Leu Phe Asp Thr Gln His Phe Ile Ser Lys Glu Arg Ala
                2005                2010                2015    
Glu Ala Leu Met Met Pro Leu Val Asp Gln Leu Glu Asn Arg Leu Gly
            2020                2025                2030        
Gly Glu Glu Lys Phe Gln Glu Arg Val Thr Lys His Leu Ile Pro Cys
        2035                2040                2045            
Ile Ala Gln Phe Ser Val Ala Met Ala Asp Asp Ser Leu Trp Lys Pro
    2050                2055                2060                
Leu Asn Tyr Gln Ile Leu Leu Lys Thr Arg Asp Ser Ser Pro Lys Val
2065                2070                2075                2080
Arg Phe Ala Ala Leu Ile Thr Val Leu Ala Leu Ala Glu Lys Leu Lys
                2085                2090                2095    
Glu Asn Tyr Ile Val Leu Leu Pro Glu Ser Ile Pro Phe Leu Ala Glu
            2100                2105                2110        
Leu Met Glu Asp Glu Cys Glu Glu Val Glu His Gln Cys Gln Lys Thr
        2115                2120                2125            
Ile Gln Gln Leu Glu Thr Val Leu Gly Glu Pro Leu Gln Ser Tyr Phe
    2130                2135                2140                


<210> 7083
<211> 2116
<212> PRT
<213> Homo sapiens

<400> 7083
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu
 1               5                  10                  15      
Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu
            20                  25                  30          
Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val
        35                  40                  45              
Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe
    50                  55                  60                  
Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser
65                  70                  75                  80  
Asn Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro
                85                  90                  95      
Lys Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu
            100                 105                 110         
Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro
        115                 120                 125             
Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser
    130                 135                 140                 
Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln
145                 150                 155                 160 
Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser
                165                 170                 175     
Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu
            180                 185                 190         
Asp Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val
        195                 200                 205             
Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu
    210                 215                 220                 
Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu
225                 230                 235                 240 
Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser
                245                 250                 255     
Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser
            260                 265                 270         
Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser
        275                 280                 285             
Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His
    290                 295                 300                 
Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu
305                 310                 315                 320 
Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn
                325                 330                 335     
Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val
            340                 345                 350         
Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu
        355                 360                 365             
Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu
    370                 375                 380                 
Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met
385                 390                 395                 400 
Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu
                405                 410                 415     
Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala
            420                 425                 430         
Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala
        435                 440                 445             
Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr
    450                 455                 460                 
Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn
465                 470                 475                 480 
Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Asn Val Leu Ala
                485                 490                 495     
Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu Gln
            500                 505                 510         
Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys Arg
        515                 520                 525             
Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu Tyr
    530                 535                 540                 
Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro Ser
545                 550                 555                 560 
Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly Leu
                565                 570                 575     
Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu Leu
            580                 585                 590         
Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys Leu
        595                 600                 605             
Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu Asp
    610                 615                 620                 
Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln Arg
625                 630                 635                 640 
His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu Lys
                645                 650                 655     
Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu Ala
            660                 665                 670         
His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu Gln
        675                 680                 685             
Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg Leu
    690                 695                 700                 
Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala Ser
705                 710                 715                 720 
Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu Glu
                725                 730                 735     
Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu Gln
            740                 745                 750         
Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu Arg
        755                 760                 765             
Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg Glu
    770                 775                 780                 
Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala Gln
785                 790                 795                 800 
Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala Leu
                805                 810                 815     
Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln Glu
            820                 825                 830         
Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu Leu
        835                 840                 845             
Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu Lys
    850                 855                 860                 
Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met Leu
865                 870                 875                 880 
Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg Gln
                885                 890                 895     
Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr Gln
            900                 905                 910         
Gln Ser Leu Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His Lys
        915                 920                 925             
Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala Ser
    930                 935                 940                 
Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His Asp
945                 950                 955                 960 
Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn Ile
                965                 970                 975     
His Lys Ala Thr Cys Glu Thr Ala Asp Arg Glu Arg Ala Glu Met Ser
            980                 985                 990         
Thr Glu Ile Ser Arg Leu Gln Ser Lys Ile Lys Glu Met Gln Gln Ala
        995                 1000                1005            
Thr Ser Pro Leu Ser Met Leu Gln Ser Gly Cys Gln Val Ile Gly Glu
    1010                1015                1020                
Glu Glu Val Glu Gly Asp Gly Ala Leu Ser Leu Leu Gln Gln Gly Glu
1025                1030                1035                1040
Gln Leu Leu Glu Glu Asn Gly Asp Val Leu Leu Ser Leu Gln Arg Ala
                1045                1050                1055    
His Glu Gln Ala Val Lys Glu Asn Val Lys Met Ala Thr Glu Ile Ser
            1060                1065                1070        
Arg Leu Gln Gln Arg Leu Gln Lys Leu Glu Pro Gly Leu Val Met Ser
        1075                1080                1085            
Ser Cys Leu Asp Glu Pro Ala Thr Glu Phe Phe Gly Asn Thr Ala Glu
    1090                1095                1100                
Gln Thr Glu Pro Phe Leu Gln Gln Asn Arg Thr Lys Gln Val Glu Gly
1105                1110                1115                1120
Val Thr Arg Arg His Val Leu Ser Asp Leu Glu Asp Asp Glu Val Arg
                1125                1130                1135    
Asp Leu Gly Ser Thr Gly Thr Ser Ser Val Gln Arg Gln Glu Val Lys
            1140                1145                1150        
Ile Glu Glu Ser Glu Ala Ser Val Glu Gly Phe Ser Glu Leu Glu Asn
        1155                1160                1165            
Ser Glu Glu Thr Arg Thr Glu Ser Trp Glu Leu Lys Asn Gln Ile Ser
    1170                1175                1180                
Gln Leu Gln Glu Gln Leu Met Met Leu Cys Ala Asp Cys Asp Arg Ala
1185                1190                1195                1200
Ser Glu Lys Lys Gln Asp Leu Leu Phe Asp Val Ser Val Leu Lys Lys
                1205                1210                1215    
Lys Leu Lys Met Leu Glu Arg Ile Pro Glu Ala Ser Pro Lys Tyr Lys
            1220                1225                1230        
Leu Leu Tyr Glu Asp Val Ser Arg Glu Asn Asp Cys Leu Gln Glu Glu
        1235                1240                1245            
Leu Arg Met Met Glu Thr Arg Tyr Asp Glu Ala Leu Glu Asn Asn Lys
    1250                1255                1260                
Glu Leu Thr Ala Glu Val Phe Arg Leu Gln Asp Glu Leu Lys Lys Met
1265                1270                1275                1280
Glu Glu Val Thr Glu Thr Phe Leu Ser Leu Glu Lys Ser Tyr Asp Glu
                1285                1290                1295    
Val Lys Ile Glu Asn Glu Glu Leu Asn Val Leu Val Leu Arg Leu Gln
            1300                1305                1310        
Gly Lys Ile Glu Lys Leu Gln Glu Ser Val Val Gln Arg Cys Asp Cys
        1315                1320                1325            
Cys Leu Trp Glu Ala Ser Leu Glu Asn Leu Glu Ile Glu Pro Asp Gly
    1330                1335                1340                
Asn Ile Leu Gln Leu Asn Gln Thr Leu Glu Glu Cys Val Pro Arg Val
1345                1350                1355                1360
Arg Ser Val His His Val Ile Glu Glu Cys Lys Gln Glu Asn Gln Tyr
                1365                1370                1375    
Leu Glu Gly Asn Thr Gln Leu Leu Glu Lys Val Lys Ala His Glu Ile
            1380                1385                1390        
Ala Trp Leu His Gly Thr Ile Gln Thr His Gln Glu Arg Pro Arg Val
        1395                1400                1405            
Gln Asn Gln Val Ile Leu Glu Glu Asn Thr Thr Leu Leu Gly Phe Gln
    1410                1415                1420                
Asp Lys His Phe Gln His Gln Ala Thr Ile Ala Glu Leu Glu Leu Glu
1425                1430                1435                1440
Lys Thr Lys Leu Gln Glu Leu Thr Arg Lys Leu Lys Glu Arg Val Thr
                1445                1450                1455    
Ile Leu Val Lys Gln Lys Asp Val Leu Ser His Gly Glu Lys Glu Glu
            1460                1465                1470        
Glu Leu Lys Ala Met Met His Asp Leu Gln Ile Thr Cys Ser Glu Met
        1475                1480                1485            
Gln Gln Lys Val Glu Leu Leu Arg Tyr Glu Ser Glu Lys Leu Gln Gln
    1490                1495                1500                
Glu Asn Ser Ile Leu Arg Asn Glu Ile Thr Thr Leu Asn Glu Glu Asp
1505                1510                1515                1520
Ser Ile Ser Asn Leu Lys Leu Gly Thr Leu Asn Gly Ser Gln Glu Glu
                1525                1530                1535    
Met Trp Gln Lys Thr Glu Thr Val Lys Gln Glu Asn Ala Ala Val Gln
            1540                1545                1550        
Lys Met Val Glu Asn Leu Lys Lys Gln Ile Ser Glu Leu Lys Ile Lys
        1555                1560                1565            
Asn Gln Gln Leu Asp Leu Glu Asn Thr Glu Leu Ser Gln Lys Asn Ser
    1570                1575                1580                
Gln Asn Gln Glu Lys Leu Gln Glu Leu Asn Gln Arg Leu Thr Glu Met
1585                1590                1595                1600
Leu Cys Gln Lys Glu Lys Glu Pro Gly Asn Ser Ala Leu Glu Glu Arg
                1605                1610                1615    
Glu Gln Glu Lys Phe Asn Leu Lys Glu Glu Leu Glu Arg Cys Lys Val
            1620                1625                1630        
Gln Ser Ser Thr Leu Val Ser Ser Leu Glu Ala Glu Leu Ser Glu Val
        1635                1640                1645            
Lys Ile Gln Thr His Ile Val Gln Gln Glu Asn His Leu Leu Lys Asp
    1650                1655                1660                
Glu Leu Glu Lys Met Lys Gln Leu His Arg Cys Pro Asp Leu Ser Asp
1665                1670                1675                1680
Phe Gln Gln Lys Ile Ser Ser Val Leu Ser Tyr Asn Glu Lys Leu Leu
                1685                1690                1695    
Lys Glu Lys Glu Ala Leu Ser Glu Glu Leu Asn Ser Cys Val Asp Lys
            1700                1705                1710        
Leu Ala Lys Ser Ser Leu Leu Glu His Arg Ile Ala Thr Met Lys Gln
        1715                1720                1725            
Glu Gln Lys Ser Trp Glu His Gln Ser Ala Ser Leu Lys Ser Gln Leu
    1730                1735                1740                
Val Ala Ser Gln Glu Lys Val Gln Asn Leu Glu Asp Thr Val Gln Asn
1745                1750                1755                1760
Val Asn Leu Gln Met Ser Arg Met Lys Ser Asp Leu Arg Val Thr Gln
                1765                1770                1775    
Gln Glu Lys Glu Ala Leu Lys Gln Glu Val Met Ser Leu His Lys Gln
            1780                1785                1790        
Leu Gln Asn Ala Gly Gly Lys Ser Trp Ala Pro Glu Ile Ala Thr His
        1795                1800                1805            
Pro Ser Gly Leu His Asn Gln Gln Lys Arg Leu Ser Trp Asp Lys Leu
    1810                1815                1820                
Asp His Leu Met Asn Glu Glu Gln Gln Leu Leu Trp Gln Glu Asn Glu
1825                1830                1835                1840
Arg Leu Gln Thr Met Val Gln Asn Thr Lys Ala Glu Leu Thr His Ser
                1845                1850                1855    
Arg Glu Lys Val Arg Gln Leu Glu Ser Asn Leu Leu Pro Lys His Gln
            1860                1865                1870        
Lys His Leu Asn Pro Ser Gly Thr Met Asn Pro Thr Glu Gln Glu Lys
        1875                1880                1885            
Leu Ser Leu Lys Arg Glu Cys Asp Gln Phe Gln Lys Glu Gln Ser Pro
    1890                1895                1900                
Ala Asn Arg Lys Val Ser Gln Met Asn Ser Leu Glu Gln Glu Leu Glu
1905                1910                1915                1920
Thr Ile His Leu Glu Asn Glu Gly Leu Lys Lys Lys Gln Val Lys Leu
                1925                1930                1935    
Asp Glu Gln Leu Met Glu Met Gln His Leu Arg Ser Thr Ala Thr Pro
            1940                1945                1950        
Ser Pro Ser Pro His Ala Trp Asp Leu Gln Leu Leu Gln Gln Gln Ala
        1955                1960                1965            
Cys Pro Met Val Pro Arg Glu Gln Phe Leu Gln Leu Gln Arg Gln Leu
    1970                1975                1980                
Leu Gln Ala Glu Arg Ile Asn Gln His Leu Gln Glu Glu Leu Glu Asn
1985                1990                1995                2000
Arg Thr Ser Glu Thr Asn Thr Pro Gln Gly Asn Gln Glu Gln Leu Val
                2005                2010                2015    
Thr Val Met Glu Glu Arg Met Ile Glu Val Glu Gln Lys Leu Lys Leu
            2020                2025                2030        
Val Lys Arg Leu Leu Gln Glu Lys Val Asn Gln Leu Lys Glu Gln Leu
        2035                2040                2045            
Cys Lys Asn Thr Lys Ala Asp Ala Met Val Lys Asp Leu Tyr Val Glu
    2050                2055                2060                
Asn Ala Gln Leu Leu Lys Ala Leu Glu Val Thr Glu Gln Arg Gln Lys
2065                2070                2075                2080
Thr Ala Glu Lys Lys Asn Tyr Leu Leu Glu Glu Lys Ile Ala Ser Leu
                2085                2090                2095    
Ser Asn Ile Val Arg Asn Leu Thr Pro Ala Pro Leu Thr Ser Thr Pro
            2100                2105                2110        
Pro Leu Arg Ser
        2115    


<210> 7084
<211> 195
<212> PRT
<213> Homo sapiens

<400> 7084
Leu Arg Gly Asn Ser Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp
 1               5                  10                  15      
Ala Leu Lys Ile Asn Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn
            20                  25                  30          
Thr Val Arg Asp Asp Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser
        35                  40                  45              
Asn Arg Thr Leu Ser Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro
    50                  55                  60                  
Met Gly Ala Gln Arg Met Ala Asp Ala Leu Lys Gln Asn Arg Ser Leu
65                  70                  75                  80  
Lys Glu Leu Met Phe Ser Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys
                85                  90                  95      
Ala Leu Ala Glu Ala Leu Lys Val Asn Gln Gly Leu Glu Ser Leu Asp
            100                 105                 110         
Leu Gln Ser Asn Ser Ile Ser Asp Ala Gly Val Ala Ala Leu Met Gly
        115                 120                 125             
Ala Leu Cys Thr Asn Gln Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn
    130                 135                 140                 
Ser Ile Ser Pro Glu Gly Ala Gln Ala Ile Ala His Ala Leu Cys Ala
145                 150                 155                 160 
Asn Ser Thr Leu Lys Asn Leu Asp Leu Gln Trp Asn Phe Ile Gln Ala
                165                 170                 175     
Gly Ala Ala Gln Ala Leu Gly Gln Ala Leu Gln Leu Asn Arg Ser Leu
            180                 185                 190         
Thr Ser Leu
        195 


<210> 7085
<211> 1112
<212> PRT
<213> Homo sapiens

<400> 7085
Met Glu Met Asp Ala Pro Arg Pro Pro Ser Leu Ala Val Pro Gly Ala
 1               5                  10                  15      
Ala Ser Arg Pro Gly Arg Leu Leu Asp Gly Gly His Gly Arg Gln Gln
            20                  25                  30          
Val Gln Ala Leu Ser Ser Gln Leu Leu Glu Val Ile Pro Asp Ser Met
        35                  40                  45              
Arg Lys Gln Glu Val Arg Thr Gly Arg Glu Ala Gly Gln Gly His Gly
    50                  55                  60                  
Thr Gly Ser Pro Ala Glu Gln Val Lys Ala Leu Met Asp Leu Leu Ala
65                  70                  75                  80  
Gly Lys Gly Ser Gln Gly Ser His Ala Pro Gln Ala Leu Asp Arg Thr
                85                  90                  95      
Pro Asp Ala Pro Leu Gly Pro Cys Ser Asn Asp Ser Arg Ile Gln Arg
            100                 105                 110         
His Arg Lys Ala Leu Leu Ser Lys Val Gly Gly Gly Pro Glu Leu Gly
        115                 120                 125             
Gly Pro Trp His Arg Leu Ala Ser Leu Leu Leu Val Glu Gly Leu Thr
    130                 135                 140                 
Asp Leu Gln Leu Arg Glu His Asp Phe Thr Gln Val Glu Ala Thr Arg
145                 150                 155                 160 
Gly Gly Gly His Pro Ala Arg Thr Val Ala Leu Asp Arg Leu Phe Leu
                165                 170                 175     
Pro Leu Ser Arg Val Ser Val Pro Pro Arg Val Ser Ile Thr Ile Gly
            180                 185                 190         
Val Ala Gly Met Gly Lys Thr Thr Leu Val Arg His Phe Val Arg Leu
        195                 200                 205             
Trp Ala His Gly Gln Val Gly Lys Asp Phe Ser Leu Val Leu Pro Leu
    210                 215                 220                 
Thr Phe Arg Asp Leu Asn Thr His Glu Lys Leu Cys Ala Asp Arg Leu
225                 230                 235                 240 
Ile Cys Ser Val Phe Pro His Val Gly Glu Pro Ser Leu Ala Val Ala
                245                 250                 255     
Val Pro Ala Arg Ala Leu Leu Ile Leu Asp Gly Leu Asp Glu Cys Arg
            260                 265                 270         
Thr Pro Leu Asp Phe Ser Asn Thr Val Ala Cys Thr Asp Pro Lys Lys
        275                 280                 285             
Glu Ile Pro Val Asp His Leu Ile Thr Asn Ile Ile Arg Gly Asn Leu
    290                 295                 300                 
Phe Pro Glu Val Ser Ile Trp Ile Thr Ser Arg Pro Ser Ala Ser Gly
305                 310                 315                 320 
Gln Ile Pro Gly Gly Leu Val Asp Arg Met Thr Glu Ile Arg Gly Phe
                325                 330                 335     
Asn Glu Glu Glu Ile Lys Val Cys Leu Glu Gln Met Phe Pro Glu Asp
            340                 345                 350         
Gln Ala Leu Leu Gly Trp Met Leu Ser Gln Val Gln Ala Asp Arg Ala
        355                 360                 365             
Leu Tyr Leu Met Cys Thr Val Pro Ala Phe Cys Arg Leu Thr Gly Met
    370                 375                 380                 
Ala Leu Gly His Leu Trp Arg Ser Arg Thr Gly Pro Gln Asp Ala Glu
385                 390                 395                 400 
Leu Trp Pro Pro Arg Thr Leu Cys Glu Leu Tyr Ser Trp Tyr Phe Arg
                405                 410                 415     
Met Ala Leu Ser Gly Glu Gly Gln Glu Lys Gly Lys Ala Ser Pro Arg
            420                 425                 430         
Ile Glu Gln Val Ala His Gly Gly Arg Lys Met Val Gly Thr Leu Gly
        435                 440                 445             
Arg Leu Ala Phe His Gly Leu Leu Lys Lys Lys Tyr Val Phe Tyr Glu
    450                 455                 460                 
Gln Asp Met Lys Ala Phe Gly Val Asp Leu Ala Leu Leu Gln Gly Ala
465                 470                 475                 480 
Pro Cys Ser Cys Phe Leu Gln Arg Glu Glu Thr Leu Ala Ser Ser Val
                485                 490                 495     
Ala Tyr Cys Phe Thr His Leu Ser Leu Gln Glu Phe Val Ala Ala Ala
            500                 505                 510         
Tyr Tyr Tyr Gly Ala Ser Arg Arg Ala Ile Phe Asp Leu Phe Thr Glu
        515                 520                 525             
Ser Gly Val Ser Trp Pro Arg Leu Gly Phe Leu Thr His Phe Arg Ser
    530                 535                 540                 
Ala Ala Gln Arg Ala Met Gln Ala Glu Asp Gly Arg Leu Asp Val Phe
545                 550                 555                 560 
Leu Arg Phe Leu Ser Gly Leu Leu Ser Pro Arg Val Asn Ala Leu Leu
                565                 570                 575     
Ala Gly Ser Leu Leu Ala Gln Gly Glu His Gln Ala Tyr Arg Thr Gln
            580                 585                 590         
Val Ala Glu Leu Leu Gln Gly Cys Leu Arg Pro Asp Ala Ala Val Cys
        595                 600                 605             
Ala Arg Ala Ile Asn Val Leu His Cys Leu His Glu Leu Gln His Thr
    610                 615                 620                 
Glu Leu Ala Arg Ser Val Glu Glu Ala Met Glu Ser Gly Ala Leu Ala
625                 630                 635                 640 
Arg Leu Thr Gly Pro Ala His Arg Ala Ala Leu Ala Tyr Leu Leu Gln
                645                 650                 655     
Val Ser Asp Ala Cys Ala Gln Glu Ala Asn Leu Ser Leu Ser Leu Ser
            660                 665                 670         
Gln Gly Val Leu Gln Ser Leu Leu Pro Gln Leu Leu Tyr Cys Arg Lys
        675                 680                 685             
Leu Arg Leu Asp Thr Asn Gln Phe Gln Asp Pro Val Met Glu Leu Leu
    690                 695                 700                 
Gly Ser Val Leu Ser Gly Lys Asp Cys Arg Ile Gln Lys Ile Ser Leu
705                 710                 715                 720 
Ala Glu Asn Gln Ile Ser Asn Lys Gly Ala Lys Ala Leu Ala Arg Ser
                725                 730                 735     
Leu Leu Val Asn Arg Ser Leu Thr Ser Leu Asp Leu Arg Gly Asn Ser
            740                 745                 750         
Ile Gly Pro Gln Gly Ala Lys Ala Leu Ala Asp Ala Leu Lys Ile Asn
        755                 760                 765             
Arg Thr Leu Thr Ser Leu Ser Leu Gln Gly Asn Thr Val Arg Asp Asp
    770                 775                 780                 
Gly Ala Arg Ser Met Ala Glu Ala Leu Ala Ser Asn Arg Thr Leu Ser
785                 790                 795                 800 
Met Leu His Leu Gln Lys Asn Ser Ile Gly Pro Met Gly Ala Gln Arg
                805                 810                 815     
Met Ala Asp Ala Leu Lys Gln Asn Arg Ser Leu Lys Glu Leu Met Phe
            820                 825                 830         
Ser Ser Asn Ser Ile Gly Asp Gly Gly Ala Lys Ala Leu Ala Glu Ala
        835                 840                 845             
Leu Lys Val Asn Gln Gly Leu Glu Ser Leu Asp Leu Gln Ser Asn Ser
    850                 855                 860                 
Ile Ser Asp Ala Gly Val Ala Ala Leu Met Gly Ala Leu Cys Thr Asn
865                 870                 875                 880 
Gln Thr Leu Leu Ser Leu Ser Leu Arg Glu Asn Ser Ile Ser Pro Glu
                885                 890                 895     
Gly Ala Gln Ala Ile Ala His Ala Leu Cys Ala Asn Ser Thr Leu Lys
            900                 905                 910         
Asn Leu Asp Leu Thr Ala Asn Leu Leu His Asp Gln Gly Ala Arg Ala
        915                 920                 925             
Ile Ala Val Ala Val Arg Glu Asn Arg Thr Leu Thr Ser Leu His Leu
    930                 935                 940                 
Gln Trp Asn Phe Ile Gln Ala Gly Ala Ala Gln Ala Leu Gly Gln Ala
945                 950                 955                 960 
Leu Gln Leu Asn Arg Ser Leu Thr Ser Leu Asp Leu Gln Glu Asn Ala
                965                 970                 975     
Ile Gly Asp Asp Gly Ala Cys Ala Val Ala Arg Ala Leu Lys Val Asn
            980                 985                 990         
Thr Ala Leu Thr Ala Leu Tyr Leu Gln Val Ala Ser Ile Gly Ala Ser
        995                 1000                1005            
Gly Ala Gln Val Leu Gly Glu Ala Leu Ala Val Asn Arg Thr Leu Glu
    1010                1015                1020                
Ile Leu Asp Leu Arg Gly Asn Ala Ile Gly Val Ala Gly Ala Lys Ala
1025                1030                1035                1040
Leu Ala Asn Ala Leu Lys Val Asn Ser Ser Leu Arg Arg Leu Asn Leu
                1045                1050                1055    
Gln Glu Asn Ser Leu Gly Met Asp Gly Ala Ile Cys Ile Ala Thr Ala
            1060                1065                1070        
Leu Ser Gly Asn His Arg Leu Gln His Ile Asn Leu Gln Gly Asn His
        1075                1080                1085            
Ile Gly Asp Ser Gly Ala Arg Met Ile Ser Glu Ala Ile Lys Thr Asn
    1090                1095                1100                
Ala Pro Thr Cys Thr Val Glu Met
1105                1110        


<210> 7086
<211> 984
<212> PRT
<213> Homo sapiens

<400> 7086
Met Asp Asp Arg Tyr Pro Ala Leu Gln Arg Ala Gln Leu Arg Leu Asp
 1               5                  10                  15      
Phe Ile His Ala Asn Ser Thr Thr His Ser Phe Leu Phe Gly Ala Leu
            20                  25                  30          
Ala Glu Leu Leu Asp Asn Ala Arg Asp Ala Gly Ala Glu Arg Leu Asp
        35                  40                  45              
Val Phe Ser Val Asp Asn Glu Lys Leu Gln Gly Gly Phe Met Leu Cys
    50                  55                  60                  
Phe Leu Asp Asp Gly Cys Gly Met Ser Pro Glu Glu Ala Ser Asp Ile
65                  70                  75                  80  
Ile Tyr Phe Gly Arg Ser Lys Lys Arg Leu Ser Thr Leu Lys Phe Ile
                85                  90                  95      
Gly Gln Tyr Gly Asn Gly Leu Lys Ser Gly Ser Met Arg Ile Gly Lys
            100                 105                 110         
Asp Phe Ile Leu Phe Thr Lys Lys Glu Glu Thr Met Thr Cys Val Phe
        115                 120                 125             
Phe Ser Gln Thr Phe Cys Glu Glu Glu Ser Leu Ser Glu Val Val Val
    130                 135                 140                 
Pro Met Pro Ser Trp Leu Ile Arg Thr Arg Glu Ser Val Thr Asp Asp
145                 150                 155                 160 
Pro Gln Lys Phe Ala Met Glu Leu Ser Ile Ile Tyr Lys Tyr Ser Pro
                165                 170                 175     
Phe Lys Thr Glu Ala Glu Leu Met Gln Gln Phe Asp Val Ile Tyr Gly
            180                 185                 190         
Lys Cys Gly Thr Leu Leu Val Ile Tyr Asn Leu Lys Leu Leu Leu Asn
        195                 200                 205             
Gly Glu Pro Glu Leu Asp Val Lys Thr Asp Lys Glu Asp Ile Leu Met
    210                 215                 220                 
Ala Gly Ala Leu Glu Asp Phe Pro Ala Arg Trp Ser Phe Arg Ala Tyr
225                 230                 235                 240 
Thr Ser Val Leu Tyr Phe Asn Pro Trp Met Arg Ile Phe Ile Gln Ala
                245                 250                 255     
Lys Arg Val Lys Thr Lys His Leu Cys Tyr Cys Leu Tyr Arg Pro Arg
            260                 265                 270         
Lys Tyr Leu Tyr Val Thr Ser Ser Phe Lys Gly Ala Phe Lys Asp Glu
        275                 280                 285             
Val Lys Lys Ala Glu Glu Ala Val Lys Ile Ala Glu Ser Ile Leu Lys
    290                 295                 300                 
Glu Ala Gln Ile Lys Val Asn Gln Cys Asp Arg Thr Ser Leu Ser Ser
305                 310                 315                 320 
Ala Lys Asp Val Leu Gln Arg Ala Leu Glu Asp Val Glu Ala Lys Gln
                325                 330                 335     
Lys Asn Leu Lys Glu Lys Gln Arg Glu Leu Lys Thr Ala Arg Thr Leu
            340                 345                 350         
Ser Leu Phe Tyr Gly Val Asn Val Glu Asn Arg Ser Gln Ala Gly Met
        355                 360                 365             
Phe Ile Tyr Ser Asn Asn Arg Leu Ile Lys Met His Glu Lys Val Gly
    370                 375                 380                 
Ser Gln Leu Lys Leu Lys Ser Leu Leu Gly Ala Gly Val Val Gly Ile
385                 390                 395                 400 
Val Asn Ile Pro Leu Glu Val Met Glu Pro Ser His Asn Lys Gln Glu
                405                 410                 415     
Phe Leu Asn Val Gln Glu Tyr Asn His Leu Leu Lys Val Met Gly Gln
            420                 425                 430         
Tyr Leu Val Gln Tyr Cys Lys Asp Thr Gly Ile Asn Asn Arg Asn Leu
        435                 440                 445             
Thr Leu Phe Cys Asn Glu Phe Gly Tyr Gln Asn Asp Ile Asp Val Glu
    450                 455                 460                 
Lys Pro Leu Asn Ser Ile Gln Tyr Gln Arg Arg Gln Ala Met Gly Ile
465                 470                 475                 480 
Pro Phe Ile Ile Gln Cys Asp Leu Cys Leu Lys Trp Arg Val Leu Pro
                485                 490                 495     
Ser Ser Thr Asn Tyr Gln Glu Lys Glu Phe Phe Asp Ile Trp Ile Cys
            500                 505                 510         
Ala Asn Asn Pro Asn Arg Leu Glu Asn Ser Cys His Gln Val Glu Cys
        515                 520                 525             
Leu Pro Ser Ile Pro Leu Gly Thr Met Ser Thr Ile Ser Pro Ser Lys
    530                 535                 540                 
Asn Glu Lys Glu Lys Gln Leu Arg Glu Ser Val Ile Lys Tyr Gln Asn
545                 550                 555                 560 
Arg Leu Ala Glu Gln Gln Pro Gln Pro Gln Phe Ile Pro Val Asp Glu
                565                 570                 575     
Ile Thr Val Thr Ser Thr Cys Leu Thr Ser Ala His Lys Glu Asn Thr
            580                 585                 590         
Lys Thr Gln Lys Ile Arg Leu Leu Gly Asp Asp Leu Lys His Glu Ser
        595                 600                 605             
Leu Ser Ser Phe Glu Leu Ser Ala Ser Arg Arg Gly Gln Lys Arg Asn
    610                 615                 620                 
Ile Glu Glu Thr Asp Ser Asp Val Glu Tyr Ile Ser Glu Thr Lys Ile
625                 630                 635                 640 
Met Lys Lys Ser Met Glu Glu Lys Met Asn Ser Gln Gln Gln Arg Ile
                645                 650                 655     
Pro Val Ala Leu Pro Glu Asn Val Lys Leu Ala Glu Arg Ser Gln Arg
            660                 665                 670         
Ser Gln Ile Ala Asn Ile Thr Thr Val Trp Arg Ala Gln Pro Thr Glu
        675                 680                 685             
Gly Cys Leu Lys Asn Ala Gln Ala Ala Ser Trp Glu Met Lys Arg Lys
    690                 695                 700                 
Gln Ser Leu Asn Phe Val Glu Glu Cys Lys Val Leu Thr Glu Asp Glu
705                 710                 715                 720 
Asn Thr Ser Asp Ser Asp Ile Ile Leu Val Ser Asp Lys Ser Asn Thr
                725                 730                 735     
Asp Val Ser Leu Lys Gln Glu Lys Lys Glu Ile Pro Leu Leu Asn Gln
            740                 745                 750         
Glu Lys Gln Glu Leu Cys Asn Asp Val Leu Ala Met Lys Arg Ser Ser
        755                 760                 765             
Ser Leu Pro Ser Trp Lys Ser Leu Leu Asn Val Pro Met Glu Asp Val
    770                 775                 780                 
Asn Leu Ser Ser Gly His Ile Ala Arg Val Ser Val Ser Gly Ser Cys
785                 790                 795                 800 
Lys Val Ala Ser Ser Pro Ala Ser Ser Gln Ser Thr Pro Val Lys Glu
                805                 810                 815     
Thr Val Arg Lys Leu Lys Ser Lys Leu Arg Glu Ile Leu Leu Tyr Phe
            820                 825                 830         
Phe Pro Glu Tyr Gln Leu Pro Ser Glu Leu Glu Glu Pro Ala Leu Ser
        835                 840                 845             
Cys Glu Leu Glu Gln Cys Pro Glu Gln Met Asn Lys Lys Leu Lys Met
    850                 855                 860                 
Cys Phe Asn Gln Ile Gln Asn Thr Tyr Met Val Gln Tyr Glu Lys Lys
865                 870                 875                 880 
Ile Lys Arg Lys Leu Gln Ser Ile Ile Tyr Asp Ser Asn Thr Arg Gly
                885                 890                 895     
Ile His Asn Glu Ile Ser Leu Gly Gln Cys Glu Asn Lys Arg Lys Ile
            900                 905                 910         
Ser Glu Asp Lys Leu Lys Asn Leu Arg Ile Lys Leu Ala Leu Leu Leu
        915                 920                 925             
Gln Lys Leu Gln Leu Gly Gly Pro Glu Gly Asp Leu Glu Gln Thr Asp
    930                 935                 940                 
Thr Tyr Leu Glu Ala Leu Leu Lys Glu Asp Asn Leu Leu Phe Gln Asn
945                 950                 955                 960 
Asn Leu Asn Lys Val Thr Ile Asp Ala Arg His Arg Leu Pro Leu Glu
                965                 970                 975     
Lys Asn Glu Lys Thr Ser Glu Asn
            980                 


<210> 7087
<211> 334
<212> PRT
<213> Homo sapiens

<400> 7087
Met Glu Arg Lys Ile Ser Arg Ile His Leu Val Ser Glu Pro Ser Ile
 1               5                  10                  15      
Thr His Phe Leu Gln Val Ser Trp Glu Lys Thr Leu Glu Ser Gly Phe
            20                  25                  30          
Val Ile Thr Leu Thr Asp Gly His Ser Ala Trp Thr Gly Thr Val Ser
        35                  40                  45              
Glu Ser Glu Ile Ser Gln Glu Ala Asp Asp Met Ala Met Glu Lys Gly
    50                  55                  60                  
Lys Tyr Val Gly Glu Leu Arg Lys Ala Leu Leu Ser Gly Ala Gly Pro
65                  70                  75                  80  
Ala Asp Val Tyr Thr Phe Asn Phe Ser Lys Glu Ser Cys Tyr Phe Phe
                85                  90                  95      
Phe Glu Lys Asn Leu Lys Asp Val Ser Phe Arg Leu Gly Ser Phe Asn
            100                 105                 110         
Leu Glu Lys Val Glu Asn Pro Ala Glu Val Ile Arg Glu Leu Ile Cys
        115                 120                 125             
Tyr Cys Leu Asp Thr Ile Ala Glu Asn Gln Ala Lys Asn Glu His Leu
    130                 135                 140                 
Gln Lys Glu Asn Glu Arg Leu Leu Arg Asp Trp Asn Asp Val Gln Gly
145                 150                 155                 160 
Arg Phe Glu Lys Cys Val Ser Ala Lys Glu Ala Leu Glu Thr Asp Leu
                165                 170                 175     
Tyr Lys Arg Phe Ile Leu Val Leu Asn Glu Lys Lys Thr Lys Ile Arg
            180                 185                 190         
Ser Leu His Asn Lys Leu Leu Asn Ala Ala Gln Glu Arg Glu Lys Asp
        195                 200                 205             
Ile Lys Gln Glu Gly Glu Thr Ala Ile Cys Ser Glu Met Thr Ala Asp
    210                 215                 220                 
Arg Asp Pro Val Tyr Asp Glu Ser Thr Asp Glu Glu Ser Glu Asn Gln
225                 230                 235                 240 
Thr Asp Leu Ser Gly Leu Ala Ser Ala Ala Val Ser Lys Asp Asp Ser
                245                 250                 255     
Ile Ile Ser Ser Leu Asp Val Thr Asp Ile Ala Pro Ser Arg Lys Arg
            260                 265                 270         
Arg Gln Arg Met Gln Arg Asn Leu Gly Thr Glu Pro Lys Met Ala Pro
        275                 280                 285             
Gln Glu Asn Gln Leu Gln Glu Lys Glu Lys Pro Asp Ser Ser Leu Pro
    290                 295                 300                 
Glu Thr Ser Lys Lys Glu His Ile Ser Ala Glu Asn Met Ser Leu Glu
305                 310                 315                 320 
Thr Leu Arg Asn Ser Ser Pro Glu Asp Leu Phe Asp Glu Ile
                325                 330                 


<210> 7088
<211> 336
<212> PRT
<213> Homo sapiens

<400> 7088
Met Glu Arg Lys Ile Ser Arg Ile His Leu Val Ser Glu Pro Ser Ile
 1               5                  10                  15      
Thr His Phe Leu Gln Val Ser Trp Glu Lys Thr Leu Glu Ser Gly Phe
            20                  25                  30          
Val Ile Thr Leu Thr Asp Gly His Ser Ala Trp Thr Gly Thr Val Ser
        35                  40                  45              
Glu Ser Glu Ile Ser Gln Glu Ala Asp Asp Met Ala Met Glu Lys Gly
    50                  55                  60                  
Lys Tyr Val Gly Glu Leu Arg Lys Ala Leu Leu Ser Gly Ala Gly Pro
65                  70                  75                  80  
Ala Asp Val Tyr Thr Phe Asn Phe Ser Lys Glu Ser Cys Tyr Phe Phe
                85                  90                  95      
Phe Glu Lys Asn Leu Lys Asp Val Ser Phe Arg Leu Gly Ser Phe Asn
            100                 105                 110         
Leu Glu Lys Val Glu Asn Pro Ala Glu Val Ile Arg Glu Leu Ile Cys
        115                 120                 125             
Tyr Cys Leu Asp Thr Ile Ala Glu Asn Gln Ala Lys Asn Glu His Leu
    130                 135                 140                 
Gln Lys Glu Asn Glu Arg Leu Leu Arg Asp Trp Asn Asp Val Gln Gly
145                 150                 155                 160 
Arg Phe Glu Lys Cys Val Ser Ala Lys Glu Ala Leu Glu Thr Asp Leu
                165                 170                 175     
Tyr Lys Arg Phe Ile Leu Val Leu Asn Glu Lys Lys Thr Lys Ile Arg
            180                 185                 190         
Ser Leu His Asn Lys Leu Leu Asn Ala Ala Gln Glu Arg Glu Lys Asp
        195                 200                 205             
Ile Lys Gln Glu Gly Glu Thr Ala Ile Cys Ser Glu Met Thr Ala Asp
    210                 215                 220                 
Arg Asp Pro Val Tyr Asp Glu Ser Thr Asp Glu Glu Ser Glu Asn Gln
225                 230                 235                 240 
Thr Asp Leu Ser Gly Leu Ala Ser Ala Ala Val Ser Lys Asp Asp Ser
                245                 250                 255     
Ile Ile Ser Ser Leu Asp Val Thr Asp Ile Ala Pro Ser Arg Lys Arg
            260                 265                 270         
Arg Gln Arg Met Gln Arg Asn Leu Gly Thr Glu Pro Lys Met Ala Pro
        275                 280                 285             
Gln Glu Asn Gln Leu Gln Glu Lys Glu Asn Ser Arg Pro Asp Ser Ser
    290                 295                 300                 
Leu Pro Glu Thr Ser Lys Lys Glu His Ile Ser Ala Glu Asn Met Ser
305                 310                 315                 320 
Leu Glu Thr Leu Arg Asn Ser Ser Pro Glu Asp Leu Phe Asp Glu Ile
                325                 330                 335     


<210> 7089
<211> 3062
<212> PRT
<213> Homo sapiens

<400> 7089
Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser
 1               5                  10                  15      
Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu
            20                  25                  30          
Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly
        35                  40                  45              
Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala
    50                  55                  60                  
Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu
65                  70                  75                  80  
Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val
                85                  90                  95      
Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu
            100                 105                 110         
Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly
        115                 120                 125             
Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg
    130                 135                 140                 
Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys
145                 150                 155                 160 
Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile
                165                 170                 175     
Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu
            180                 185                 190         
Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser
        195                 200                 205             
Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser
    210                 215                 220                 
Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn
225                 230                 235                 240 
Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met
                245                 250                 255     
Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu
            260                 265                 270         
Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp
        275                 280                 285             
Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp
    290                 295                 300                 
Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg
305                 310                 315                 320 
Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu
                325                 330                 335     
Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His
            340                 345                 350         
Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln
        355                 360                 365             
Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn
    370                 375                 380                 
Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp
385                 390                 395                 400 
Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala
                405                 410                 415     
Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val
            420                 425                 430         
Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu
        435                 440                 445             
Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile
    450                 455                 460                 
Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala
465                 470                 475                 480 
Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg
                485                 490                 495     
Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser
            500                 505                 510         
Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys
        515                 520                 525             
Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys
    530                 535                 540                 
Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu
545                 550                 555                 560 
Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu
                565                 570                 575     
Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His
            580                 585                 590         
Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val
        595                 600                 605             
Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp
    610                 615                 620                 
Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp
625                 630                 635                 640 
His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu
                645                 650                 655     
Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys
            660                 665                 670         
Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser
        675                 680                 685             
Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser
    690                 695                 700                 
Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln
705                 710                 715                 720 
Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu
                725                 730                 735     
Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg
            740                 745                 750         
Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu
        755                 760                 765             
Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu
    770                 775                 780                 
Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile
785                 790                 795                 800 
Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser
                805                 810                 815     
Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn
            820                 825                 830         
Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val
        835                 840                 845             
Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu
    850                 855                 860                 
Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn
865                 870                 875                 880 
Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val
                885                 890                 895     
Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys
            900                 905                 910         
Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp
        915                 920                 925             
Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg
    930                 935                 940                 
Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu
945                 950                 955                 960 
Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu
                965                 970                 975     
Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu
            980                 985                 990         
Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala Thr Gln Leu Asn Gln Gln
        995                 1000                1005            
Lys Met Leu Val Ser Glu Ile Glu Met Lys Gln Ser Lys Met Asp Glu
    1010                1015                1020                
Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala Thr Val Lys Asp Tyr Glu
1025                1030                1035                1040
Leu Gln Thr Met Thr Tyr Arg Ala Met Val Asp Ser Gln Gln Lys Ser
                1045                1050                1055    
Pro Val Lys Arg Arg Arg Met Gln Ser Ser Ala Asp Leu Ile Ile Gln
            1060                1065                1070        
Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu Val Thr Leu Met
        1075                1080                1085            
Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser Leu Lys Arg Leu Glu Glu
    1090                1095                1100                
Glu Glu Lys Ser Leu Glu Glu Glu Lys Lys Glu His Val Glu Lys Ala
1105                1110                1115                1120
Lys Glu Leu Gln Lys Trp Val Ser Asn Ile Ser Lys Thr Leu Lys Asp
                1125                1130                1135    
Ala Glu Lys Ala Gly Lys Pro Pro Phe Ser Lys Gln Lys Ile Ser Ser
            1140                1145                1150        
Glu Glu Ile Ser Thr Lys Lys Glu Gln Leu Ser Glu Ala Leu Gln Thr
        1155                1160                1165            
Ile Gln Leu Phe Leu Ala Lys His Gly Asp Lys Met Thr Asp Glu Glu
    1170                1175                1180                
Arg Asn Glu Leu Glu Lys Gln Val Lys Thr Leu Gln Glu Ser Tyr Asn
1185                1190                1195                1200
Leu Leu Phe Ser Glu Ser Leu Lys Gln Leu Gln Glu Ser Gln Thr Ser
                1205                1210                1215    
Gly Asp Val Lys Val Glu Glu Lys Leu Asp Lys Val Ile Ala Gly Thr
            1220                1225                1230        
Ile Asp Gln Thr Thr Gly Glu Val Leu Ser Val Phe Gln Ala Val Leu
        1235                1240                1245            
Arg Gly Leu Ile Asp Tyr Asp Thr Gly Ile Arg Leu Leu Glu Thr Gln
    1250                1255                1260                
Leu Met Ile Ser Gly Leu Ile Ser Pro Glu Leu Arg Lys Cys Phe Asp
1265                1270                1275                1280
Leu Lys Asp Ala Lys Ser His Gly Leu Ile Asp Glu Gln Ile Leu Cys
                1285                1290                1295    
Gln Leu Lys Glu Leu Ser Lys Ala Lys Glu Ile Ile Ser Ala Ala Ser
            1300                1305                1310        
Pro Thr Thr Ile Pro Val Leu Asp Ala Leu Ala Gln Ser Met Ile Thr
        1315                1320                1325            
Glu Ser Met Ala Ile Lys Val Leu Glu Ile Leu Leu Ser Thr Gly Ser
    1330                1335                1340                
Leu Val Ile Pro Ala Thr Gly Glu Gln Leu Thr Leu Gln Lys Ala Phe
1345                1350                1355                1360
Gln Gln Asn Leu Val Ser Ser Ala Leu Phe Ser Lys Val Leu Glu Arg
                1365                1370                1375    
Gln Asn Met Cys Lys Asp Leu Ile Asp Pro Cys Thr Ser Glu Lys Val
            1380                1385                1390        
Ser Leu Ile Asp Met Val Gln Arg Ser Thr Leu Gln Glu Asn Thr Gly
        1395                1400                1405            
Met Trp Leu Leu Pro Val Arg Pro Gln Glu Gly Gly Arg Ile Thr Leu
    1410                1415                1420                
Lys Cys Gly Arg Asn Ile Ser Ile Leu Arg Ala Ala His Glu Gly Leu
1425                1430                1435                1440
Ile Asp Arg Glu Thr Met Phe Arg Leu Leu Ser Ala Gln Leu Leu Ser
                1445                1450                1455    
Gly Gly Leu Ile Asn Ser Asn Ser Gly Gln Arg Met Thr Val Glu Glu
            1460                1465                1470        
Ala Val Arg Glu Gly Val Ile Asp Arg Asp Thr Ala Ser Ser Ile Leu
        1475                1480                1485            
Thr Tyr Gln Val Gln Thr Gly Gly Ile Ile Gln Ser Asn Pro Ala Lys
    1490                1495                1500                
Arg Leu Thr Val Asp Glu Ala Val Gln Cys Asp Leu Ile Thr Ser Ser
1505                1510                1515                1520
Ser Ala Leu Leu Val Leu Glu Ala Gln Arg Gly Tyr Val Gly Leu Ile
                1525                1530                1535    
Trp Pro His Ser Gly Glu Ile Phe Pro Thr Ser Ser Ser Leu Gln Gln
            1540                1545                1550        
Glu Leu Ile Thr Asn Glu Leu Ala Tyr Lys Ile Leu Asn Gly Arg Gln
        1555                1560                1565            
Lys Ile Ala Ala Leu Tyr Ile Pro Glu Ser Ser Gln Val Ile Gly Leu
    1570                1575                1580                
Asp Ala Ala Lys Gln Leu Gly Ile Ile Asp Asn Asn Thr Ala Ser Ile
1585                1590                1595                1600
Leu Lys Asn Ile Thr Leu Pro Asp Lys Met Pro Asp Leu Gly Asp Leu
                1605                1610                1615    
Glu Ala Cys Lys Asn Ala Arg Arg Trp Leu Ser Phe Cys Lys Phe Gln
            1620                1625                1630        
Pro Ser Thr Val His Asp Tyr Arg Gln Glu Glu Asp Val Phe Asp Gly
        1635                1640                1645            
Glu Glu Pro Val Thr Thr Gln Thr Ser Glu Glu Thr Lys Lys Leu Phe
    1650                1655                1660                
Leu Ser Tyr Leu Met Ile Asn Ser Tyr Met Asp Ala Asn Thr Gly Gln
1665                1670                1675                1680
Arg Leu Leu Leu Tyr Asp Gly Asp Leu Asp Glu Ala Val Gly Met Leu
                1685                1690                1695    
Leu Glu Gly Cys His Ala Glu Phe Asp Gly Asn Thr Ala Ile Lys Glu
            1700                1705                1710        
Cys Leu Asp Val Leu Ser Ser Ser Gly Val Phe Leu Asn Asn Ala Ser
        1715                1720                1725            
Gly Arg Glu Lys Asp Glu Cys Thr Ala Thr Pro Ser Ser Phe Asn Lys
    1730                1735                1740                
Cys His Cys Gly Glu Pro Glu His Glu Glu Thr Pro Glu Asn Arg Lys
1745                1750                1755                1760
Cys Ala Ile Asp Glu Glu Phe Asn Glu Met Arg Asn Thr Val Ile Asn
                1765                1770                1775    
Ser Glu Phe Ser Gln Ser Gly Lys Leu Ala Ser Thr Ile Ser Ile Asp
            1780                1785                1790        
Pro Lys Val Asn Ser Ser Pro Ser Val Cys Val Pro Ser Leu Ile Ser
        1795                1800                1805            
Tyr Leu Thr Gln Thr Glu Leu Ala Asp Ile Ser Met Leu Arg Ser Asp
    1810                1815                1820                
Ser Glu Asn Ile Leu Thr Asn Tyr Glu Asn Gln Ser Arg Val Glu Thr
1825                1830                1835                1840
Asn Glu Arg Ala Asn Glu Cys Ser His Ser Lys Asn Ile Gln Asn Phe
                1845                1850                1855    
Pro Ser Asp Leu Ile Glu Asn Pro Ile Met Lys Ser Lys Met Ser Lys
            1860                1865                1870        
Phe Cys Gly Val Asn Glu Thr Glu Asn Glu Asp Asn Thr Asn Arg Asp
        1875                1880                1885            
Ser Pro Ile Phe Asp Tyr Ser Pro Arg Leu Ser Ala Leu Leu Ser His
    1890                1895                1900                
Asp Lys Leu Met His Ser Gln Gly Ser Phe Asn Asp Thr His Thr Pro
1905                1910                1915                1920
Glu Ser Asn Gly Asn Lys Cys Glu Ala Pro Ala Leu Ser Phe Ser Asp
                1925                1930                1935    
Lys Thr Met Leu Ser Gly Gln Arg Ile Gly Glu Lys Phe Gln Asp Gln
            1940                1945                1950        
Phe Leu Gly Ile Ala Ala Ile Asn Ile Ser Leu Pro Gly Glu Gln Tyr
        1955                1960                1965            
Gly Gln Lys Ser Leu Asn Met Ile Ser Ser Asn Pro Gln Val Gln Tyr
    1970                1975                1980                
His Asn Asp Lys Tyr Ile Ser Asn Thr Ser Gly Glu Asp Glu Lys Thr
1985                1990                1995                2000
His Pro Gly Phe Gln Gln Met Pro Glu Asp Lys Glu Asp Glu Ser Glu
                2005                2010                2015    
Ile Glu Glu Tyr Ser Cys Ala Val Thr Pro Gly Gly Asp Thr Asp Asn
            2020                2025                2030        
Ala Ile Val Ser Leu Thr Cys Ala Thr Pro Leu Leu Asp Glu Thr Ile
        2035                2040                2045            
Ser Ala Ser Asp Tyr Glu Thr Ser Leu Leu Asn Asp Gln Gln Asn Asn
    2050                2055                2060                
Thr Gly Thr Asp Thr Asp Ser Asp Asp Asp Phe Tyr Asp Thr Pro Leu
2065                2070                2075                2080
Phe Glu Asp Asp Asp His Asp Ser Leu Leu Leu Asp Gly Asp Asp Arg
                2085                2090                2095    
Asp Cys Leu His Pro Glu Asp Tyr Asp Thr Leu Gln Glu Glu Asn Asp
            2100                2105                2110        
Glu Thr Ala Ser Pro Ala Asp Val Phe Tyr Asp Val Ser Lys Glu Asn
        2115                2120                2125            
Glu Asn Ser Met Val Pro Gln Gly Ala Pro Val Gly Ser Leu Ser Val
    2130                2135                2140                
Lys Asn Lys Ala His Cys Leu Gln Asp Phe Leu Met Asp Val Glu Lys
2145                2150                2155                2160
Asp Glu Leu Asp Ser Gly Glu Lys Ile His Leu Asn Pro Val Gly Ser
                2165                2170                2175    
Asp Lys Val Asn Gly Gln Ser Leu Glu Thr Gly Ser Glu Arg Glu Cys
            2180                2185                2190        
Thr Asn Ile Leu Glu Gly Asp Glu Ser Asp Ser Leu Thr Asp Tyr Asp
        2195                2200                2205            
Ile Val Gly Gly Lys Glu Ser Phe Thr Ala Ser Leu Lys Phe Asp Asp
    2210                2215                2220                
Ser Gly Ser Trp Arg Gly Arg Lys Glu Glu Tyr Val Thr Gly Gln Glu
2225                2230                2235                2240
Phe His Ser Asp Thr Asp His Leu Asp Ser Met Gln Ser Glu Glu Ser
                2245                2250                2255    
Tyr Gly Asp Tyr Ile Tyr Asp Ser Asn Asp Gln Asp Asp Asp Asp Asp
            2260                2265                2270        
Asp Gly Ile Asp Glu Glu Gly Gly Gly Ile Arg Asp Glu Asn Gly Lys
        2275                2280                2285            
Pro Arg Cys Gln Asn Val Ala Glu Asp Met Asp Ile Gln Leu Cys Ala
    2290                2295                2300                
Ser Ile Leu Asn Glu Asn Ser Asp Glu Asn Glu Asn Ile Asn Thr Met
2305                2310                2315                2320
Ile Leu Leu Asp Lys Met His Ser Cys Ser Ser Leu Glu Lys Gln Gln
                2325                2330                2335    
Arg Val Asn Val Val Gln Leu Ala Ser Pro Ser Glu Asn Asn Leu Val
            2340                2345                2350        
Thr Glu Lys Ser Asn Leu Pro Glu Tyr Thr Thr Glu Ile Ala Gly Lys
        2355                2360                2365            
Ser Lys Glu Asn Leu Leu Asn His Glu Met Val Leu Lys Asp Val Leu
    2370                2375                2380                
Pro Pro Ile Ile Lys Asp Thr Glu Ser Glu Lys Thr Phe Gly Pro Ala
2385                2390                2395                2400
Ser Ile Ser His Asp Asn Asn Asn Ile Ser Ser Thr Ser Glu Leu Gly
                2405                2410                2415    
Thr Asp Leu Ala Asn Thr Lys Val Lys Leu Ile Gln Gly Ser Glu Leu
            2420                2425                2430        
Pro Glu Leu Thr Asp Ser Val Lys Gly Lys Asp Glu Tyr Phe Lys Asn
        2435                2440                2445            
Met Thr Pro Lys Val Asp Ser Ser Leu Asp His Ile Ile Cys Thr Glu
    2450                2455                2460                
Pro Asp Leu Ile Gly Lys Pro Ala Glu Glu Ser His Leu Ser Leu Ile
2465                2470                2475                2480
Ala Ser Val Thr Asp Lys Asp Pro Gln Gly Asn Gly Ser Asp Leu Ile
                2485                2490                2495    
Lys Gly Arg Asp Gly Lys Ser Asp Ile Leu Ile Glu Asp Glu Thr Ser
            2500                2505                2510        
Ile Gln Lys Met Tyr Leu Gly Glu Gly Glu Val Leu Val Glu Gly Leu
        2515                2520                2525            
Val Glu Glu Glu Asn Arg His Leu Lys Leu Leu Pro Gly Lys Asn Thr
    2530                2535                2540                
Arg Asp Ser Phe Lys Leu Ile Asn Ser Gln Phe Pro Phe Pro Gln Ile
2545                2550                2555                2560
Thr Asn Asn Glu Glu Leu Asn Gln Lys Gly Ser Leu Lys Lys Ala Thr
                2565                2570                2575    
Val Thr Leu Lys Asp Glu Pro Asn Asn Leu Gln Ile Ile Val Ser Lys
            2580                2585                2590        
Ser Pro Val Gln Phe Glu Asn Leu Glu Glu Ile Phe Asp Thr Ser Val
        2595                2600                2605            
Ser Lys Glu Ile Ser Asp Asp Ile Thr Ser Asp Ile Thr Ser Trp Glu
    2610                2615                2620                
Gly Asn Thr His Phe Glu Glu Ser Phe Thr Asp Gly Pro Glu Lys Glu
2625                2630                2635                2640
Leu Asp Leu Phe Thr Tyr Leu Lys His Cys Ala Lys Asn Ile Lys Ala
                2645                2650                2655    
Lys Asp Val Ala Lys Pro Asn Glu Asp Val Pro Ser His Val Leu Ile
            2660                2665                2670        
Thr Ala Pro Pro Met Lys Glu His Leu Gln Leu Gly Val Asn Asn Thr
        2675                2680                2685            
Lys Glu Lys Ser Thr Ser Thr Gln Lys Asp Ser Pro Leu Asn Asp Met
    2690                2695                2700                
Ile Gln Ser Asn Asp Leu Cys Ser Lys Glu Ser Ile Ser Gly Gly Gly
2705                2710                2715                2720
Thr Glu Ile Ser Gln Phe Thr Pro Glu Ser Ile Glu Ala Thr Leu Ser
                2725                2730                2735    
Ile Leu Ser Arg Lys His Val Glu Asp Val Gly Lys Asn Asp Phe Leu
            2740                2745                2750        
Gln Ser Glu Arg Cys Ala Asn Gly Leu Gly Asn Asp Asn Ser Ser Asn
        2755                2760                2765            
Thr Leu Asn Thr Asp Tyr Ser Phe Leu Glu Ile Asn Asn Lys Lys Glu
    2770                2775                2780                
Arg Ile Glu Gln Gln Leu Pro Lys Glu Gln Ala Leu Ser Pro Arg Ser
2785                2790                2795                2800
Gln Glu Lys Glu Val Gln Ile Pro Glu Leu Ser Gln Val Phe Val Glu
                2805                2810                2815    
Asp Val Lys Asp Ile Leu Lys Ser Arg Leu Lys Glu Gly His Met Asn
            2820                2825                2830        
Pro Gln Glu Val Glu Glu Pro Ser Ala Cys Ala Asp Thr Lys Ile Leu
        2835                2840                2845            
Ile Gln Asn Leu Ile Lys Arg Ile Thr Thr Ser Gln Leu Val Asn Glu
    2850                2855                2860                
Ala Ser Thr Val Pro Ser Asp Ser Gln Met Ser Asp Ser Ser Gly Val
2865                2870                2875                2880
Ser Pro Met Thr Asn Ser Ser Glu Leu Lys Pro Glu Ser Arg Asp Asp
                2885                2890                2895    
Pro Phe Cys Ile Gly Asn Leu Lys Ser Glu Leu Leu Leu Asn Ile Leu
            2900                2905                2910        
Lys Gln Asp Gln His Ser Gln Lys Ile Thr Gly Val Phe Glu Leu Met
        2915                2920                2925            
Arg Glu Leu Thr His Met Glu Tyr Asp Leu Glu Lys Arg Gly Ile Thr
    2930                2935                2940                
Ser Lys Val Leu Pro Leu Gln Leu Glu Asn Ile Phe Tyr Lys Leu Leu
2945                2950                2955                2960
Ala Asp Gly Tyr Ser Glu Lys Ile Glu His Val Gly Asp Phe Asn Gln
                2965                2970                2975    
Lys Ala Cys Ser Thr Ser Glu Met Met Glu Glu Lys Pro His Ile Leu
            2980                2985                2990        
Gly Asp Ile Lys Ser Lys Glu Gly Asn Tyr Tyr Ser Pro Asn Leu Glu
        2995                3000                3005            
Thr Val Lys Glu Ile Gly Leu Glu Ser Ser Thr Val Trp Ala Ser Thr
    3010                3015                3020                
Leu Pro Arg Asp Glu Lys Leu Lys Asp Leu Cys Asn Asp Phe Pro Ser
3025                3030                3035                3040
His Leu Glu Cys Thr Ser Gly Ser Lys Glu Met Ala Ser Gly Asp Ser
                3045                3050                3055    
Ser Thr Glu Gln Val Ser
            3060        


<210> 7090
<211> 2137
<212> PRT
<213> Homo sapiens

<400> 7090
Glu Phe Asp Pro Glu Glu Phe Tyr Tyr Leu Leu Glu Ala Ala Glu Gly
 1               5                  10                  15      
His Ala Lys Glu Gly Gln Gly Ile Lys Thr Asp Ile Pro Arg Tyr Ile
            20                  25                  30          
Ile Ser Gln Leu Gly Leu Asn Lys Asp Pro Leu Glu Glu Met Ala His
        35                  40                  45              
Leu Gly Asn Tyr Asp Ser Gly Thr Ala Glu Thr Pro Glu Thr Asp Glu
    50                  55                  60                  
Ser Val Ser Ser Ser Asn Ala Ser Leu Lys Leu Arg Arg Lys Pro Arg
65                  70                  75                  80  
Glu Ser Asp Phe Glu Thr Ile Lys Leu Ile Ser Asn Gly Ala Tyr Gly
                85                  90                  95      
Ala Val Tyr Phe Val Arg His Lys Glu Ser Arg Gln Arg Phe Ala Met
            100                 105                 110         
Lys Lys Ile Asn Lys Gln Asn Leu Ile Leu Arg Asn Gln Ile Gln Gln
        115                 120                 125             
Ala Phe Val Glu Arg Asp Ile Leu Thr Phe Ala Glu Asn Pro Phe Val
    130                 135                 140                 
Val Ser Met Tyr Cys Ser Phe Glu Thr Arg Arg His Leu Cys Met Val
145                 150                 155                 160 
Met Glu Tyr Val Glu Gly Gly Asp Cys Ala Thr Leu Met Lys Asn Met
                165                 170                 175     
Gly Pro Leu Pro Val Asp Met Ala Arg Met Tyr Phe Ala Glu Thr Val
            180                 185                 190         
Leu Ala Leu Glu Tyr Leu His Asn Tyr Gly Ile Val His Arg Asp Leu
        195                 200                 205             
Lys Pro Asp Asn Leu Leu Val Thr Ser Met Gly His Ile Lys Leu Thr
    210                 215                 220                 
Asp Phe Gly Leu Ser Lys Val Gly Leu Met Ser Met Thr Thr Asn Leu
225                 230                 235                 240 
Tyr Glu Gly His Ile Glu Lys Asp Ala Arg Glu Phe Leu Asp Lys Gln
                245                 250                 255     
Val Cys Gly Thr Pro Glu Tyr Ile Ala Pro Glu Val Ile Leu Arg Gln
            260                 265                 270         
Gly Tyr Gly Lys Pro Val Asp Trp Trp Ala Met Gly Ile Ile Leu Tyr
        275                 280                 285             
Glu Phe Leu Val Gly Cys Val Pro Phe Phe Gly Asp Thr Pro Glu Glu
    290                 295                 300                 
Leu Phe Gly Gln Val Ile Ser Asp Glu Ile Asn Trp Pro Glu Lys Asp
305                 310                 315                 320 
Glu Ala Pro Pro Pro Asp Ala Gln Asp Leu Ile Thr Leu Leu Leu Arg
                325                 330                 335     
Gln Asn Pro Leu Glu Arg Leu Gly Thr Gly Gly Ala Tyr Glu Val Lys
            340                 345                 350         
Gln His Arg Phe Phe Arg Ser Leu Asp Trp Asn Ser Leu Leu Arg Gln
        355                 360                 365             
Lys Ala Glu Phe Ile Pro Gln Leu Glu Ser Glu Asp Asp Thr Ser Tyr
    370                 375                 380                 
Phe Asp Thr Arg Ser Glu Lys Tyr His His Met Glu Thr Glu Glu Glu
385                 390                 395                 400 
Asp Asp Thr Asn Asp Glu Asp Phe Asn Val Glu Ile Arg Gln Phe Ser
                405                 410                 415     
Ser Cys Ser His Arg Phe Ser Lys Val Phe Ser Ser Ile Asp Arg Ile
            420                 425                 430         
Thr Gln Asn Ser Ala Glu Glu Lys Glu Asp Ser Val Asp Lys Thr Lys
        435                 440                 445             
Ser Thr Thr Leu Pro Ser Thr Glu Thr Leu Ser Trp Ser Ser Glu Tyr
    450                 455                 460                 
Ser Glu Met Gln Gln Leu Ser Thr Ser Asn Ser Ser Asp Thr Glu Ser
465                 470                 475                 480 
Asn Arg His Lys Leu Ser Ser Gly Leu Leu Pro Lys Leu Ala Ile Ser
                485                 490                 495     
Thr Glu Gly Glu Gln Asp Glu Ala Ala Ser Cys Pro Gly Asp Pro His
            500                 505                 510         
Glu Glu Pro Gly Lys Pro Ala Leu Pro Pro Glu Glu Cys Ala Gln Glu
        515                 520                 525             
Glu Pro Glu Val Thr Thr Pro Ala Ser Thr Ile Ser Ser Ser Thr Leu
    530                 535                 540                 
Ser Val Gly Ser Phe Ser Glu His Leu Asp Gln Ile Asn Gly Arg Ser
545                 550                 555                 560 
Glu Cys Val Asp Ser Thr Asp Asn Ser Ser Lys Pro Ser Ser Glu Pro
                565                 570                 575     
Ala Ser His Met Ala Arg Gln Arg Leu Glu Ser Thr Glu Lys Lys Lys
            580                 585                 590         
Ile Ser Gly Lys Val Thr Lys Ser Leu Ser Ala Ser Ala Leu Ser Leu
        595                 600                 605             
Met Ile Pro Gly Asp Met Phe Ala Val Ser Pro Leu Gly Ser Pro Met
    610                 615                 620                 
Ser Pro His Ser Leu Ser Ser Asp Pro Ser Ser Ser Arg Asp Ser Ser
625                 630                 635                 640 
Pro Ser Arg Asp Ser Ser Ala Ala Ser Ala Ser Pro His Gln Pro Ile
                645                 650                 655     
Val Ile His Ser Ser Gly Lys Asn Tyr Gly Phe Thr Ile Arg Ala Ile
            660                 665                 670         
Arg Val Tyr Val Gly Asp Ser Asp Ile Tyr Thr Val His His Ile Val
        675                 680                 685             
Trp Asn Val Glu Glu Gly Ser Pro Ala Cys Gln Ala Gly Leu Lys Ala
    690                 695                 700                 
Gly Asp Leu Ile Thr His Ile Asn Gly Glu Pro Val His Gly Leu Val
705                 710                 715                 720 
His Thr Glu Val Ile Glu Leu Leu Leu Lys Ser Gly Asn Lys Val Ser
                725                 730                 735     
Ile Thr Thr Thr Pro Phe Glu Asn Thr Ser Ile Lys Thr Gly Pro Ala
            740                 745                 750         
Arg Arg Asn Ser Tyr Lys Ser Arg Met Val Arg Arg Ser Lys Lys Ser
        755                 760                 765             
Lys Lys Lys Glu Ser Leu Glu Arg Arg Arg Ser Leu Phe Lys Lys Leu
    770                 775                 780                 
Ala Lys Gln Pro Ser Pro Leu Leu His Thr Ser Arg Ser Phe Ser Cys
785                 790                 795                 800 
Leu Asn Arg Ser Leu Ser Ser Gly Glu Ser Leu Pro Gly Ser Pro Thr
                805                 810                 815     
His Ser Leu Ser Pro Arg Ser Pro Thr Pro Ser Tyr Arg Ser Thr Pro
            820                 825                 830         
Asp Phe Pro Ser Gly Thr Asn Ser Ser Gln Ser Ser Ser Pro Ser Ser
        835                 840                 845             
Ser Ala Pro Asn Ser Pro Ala Gly Ser Gly His Ile Arg Pro Ser Thr
    850                 855                 860                 
Leu His Gly Leu Ala Pro Lys Leu Gly Gly Gln Arg Tyr Arg Ser Gly
865                 870                 875                 880 
Arg Arg Lys Ser Ala Gly Asn Ile Pro Leu Ser Pro Leu Ala Arg Thr
                885                 890                 895     
Pro Ser Pro Thr Pro Gln Pro Thr Ser Pro Gln Arg Ser Pro Ser Pro
            900                 905                 910         
Leu Leu Gly His Ser Leu Gly Asn Ser Lys Ile Ala Gln Ala Phe Pro
        915                 920                 925             
Ser Lys Met His Ser Pro Pro Thr Ile Val Arg His Ile Val Arg Pro
    930                 935                 940                 
Lys Ser Ala Glu Pro Pro Arg Ser Pro Leu Leu Lys Arg Val Gln Ser
945                 950                 955                 960 
Glu Glu Lys Leu Ser Pro Ser Tyr Gly Ser Asp Lys Lys His Leu Cys
                965                 970                 975     
Ser Arg Lys His Ser Leu Glu Val Thr Gln Glu Glu Val Gln Arg Glu
            980                 985                 990         
Gln Ser Gln Arg Glu Ala Pro Leu Gln Ser Leu Asp Glu Asn Val Cys
        995                 1000                1005            
Asp Val Pro Pro Leu Ser Arg Ala Arg Pro Val Glu Gln Gly Cys Leu
    1010                1015                1020                
Lys Arg Pro Val Ser Arg Lys Val Gly Arg Gln Glu Ser Val Asp Asp
1025                1030                1035                1040
Leu Asp Arg Asp Lys Leu Lys Ala Lys Val Val Val Lys Lys Ala Asp
                1045                1050                1055    
Gly Phe Pro Glu Lys Gln Glu Ser His Gln Lys Ser His Gly Pro Gly
            1060                1065                1070        
Ser Asp Leu Glu Asn Phe Ala Leu Phe Lys Leu Glu Glu Arg Glu Lys
        1075                1080                1085            
Lys Val Tyr Pro Lys Ala Val Glu Arg Ser Ser Thr Phe Glu Asn Lys
    1090                1095                1100                
Ala Ser Met Gln Glu Ala Pro Pro Leu Gly Ser Leu Leu Lys Asp Ala
1105                1110                1115                1120
Leu His Lys Gln Ala Ser Val Arg Ala Ser Glu Gly Ala Met Ser Asp
                1125                1130                1135    
Gly Pro Val Pro Ala Glu His Arg Gln Gly Gly Gly Asp Phe Arg Arg
            1140                1145                1150        
Ala Pro Ala Pro Gly Thr Leu Gln Asp Gly Leu Cys His Ser Leu Asp
        1155                1160                1165            
Arg Gly Ile Ser Gly Lys Gly Glu Gly Thr Glu Lys Ser Ser Gln Ala
    1170                1175                1180                
Lys Glu Leu Leu Arg Cys Glu Lys Leu Asp Ser Lys Leu Ala Asn Ile
1185                1190                1195                1200
Asp Tyr Leu Arg Lys Lys Met Ser Leu Glu Asp Lys Glu Asp Asn Leu
                1205                1210                1215    
Cys Pro Val Leu Lys Pro Lys Met Thr Ala Gly Ser His Glu Cys Leu
            1220                1225                1230        
Pro Gly Asn Pro Val Arg Pro Thr Gly Gly Gln Gln Glu Pro Pro Pro
        1235                1240                1245            
Ala Ser Glu Ser Arg Ala Phe Val Ser Ser Thr His Ala Ala Gln Met
    1250                1255                1260                
Ser Ala Val Ser Phe Val Pro Leu Lys Ala Leu Thr Gly Arg Val Asp
1265                1270                1275                1280
Ser Gly Thr Glu Lys Pro Gly Leu Val Ala Pro Glu Ser Pro Val Arg
                1285                1290                1295    
Lys Ser Pro Ser Glu Tyr Lys Leu Glu Gly Arg Ser Val Ser Cys Leu
            1300                1305                1310        
Glu Pro Ile Glu Gly Thr Leu Asp Ile Ala Leu Leu Ser Gly Pro Gln
        1315                1320                1325            
Ala Ser Lys Thr Glu Leu Pro Ser Pro Glu Ser Ala Gln Ser Pro Ser
    1330                1335                1340                
Pro Ser Gly Asp Val Arg Ala Ser Val Pro Pro Val Leu Pro Ser Ser
1345                1350                1355                1360
Ser Gly Lys Lys Asn Asp Thr Thr Ser Ala Arg Glu Leu Ser Pro Ser
                1365                1370                1375    
Ser Leu Lys Met Asn Lys Ser Tyr Leu Leu Glu Pro Trp Phe Leu Pro
            1380                1385                1390        
Pro Ser Arg Gly Leu Gln Asn Ser Pro Ala Val Ser Leu Pro Asp Pro
        1395                1400                1405            
Glu Phe Lys Arg Asp Arg Lys Gly Pro His Pro Thr Ala Arg Ser Pro
    1410                1415                1420                
Gly Thr Val Met Glu Ser Asn Pro Gln Gln Arg Glu Gly Ser Ser Pro
1425                1430                1435                1440
Lys His Gln Asp His Thr Thr Asp Pro Lys Leu Leu Thr Cys Leu Gly
                1445                1450                1455    
Gln Asn Leu His Ser Pro Asp Leu Ala Arg Pro Arg Cys Pro Leu Pro
            1460                1465                1470        
Pro Glu Ala Ser Pro Ser Arg Glu Lys Pro Gly Leu Arg Glu Ser Ser
        1475                1480                1485            
Glu Arg Gly Pro Pro Thr Ala Arg Ser Glu Arg Ser Ala Ala Arg Ala
    1490                1495                1500                
Asp Thr Cys Arg Glu Pro Ser Met Glu Leu Cys Phe Pro Glu Thr Ala
1505                1510                1515                1520
Lys Thr Ser Asp Asn Ser Lys Asn Leu Leu Ser Val Gly Arg Thr His
                1525                1530                1535    
Pro Asp Phe Tyr Thr Gln Thr Gln Ala Met Glu Lys Ala Trp Ala Pro
            1540                1545                1550        
Gly Gly Lys Thr Asn His Lys Asp Gly Pro Gly Glu Ala Arg Pro Pro
        1555                1560                1565            
Pro Arg Asp Asn Ser Ser Leu His Ser Ala Gly Ile Pro Cys Glu Lys
    1570                1575                1580                
Glu Leu Gly Lys Val Arg Arg Gly Val Glu Pro Lys Pro Glu Ala Leu
1585                1590                1595                1600
Leu Ala Arg Arg Ser Leu Gln Pro Pro Gly Ile Glu Ser Glu Lys Ser
                1605                1610                1615    
Glu Lys Leu Ser Ser Phe Pro Ser Leu Gln Lys Asp Gly Ala Lys Glu
            1620                1625                1630        
Pro Glu Arg Lys Glu Gln Pro Leu Gln Arg His Pro Ser Ser Ile Pro
        1635                1640                1645            
Pro Pro Pro Leu Thr Ala Lys Asp Leu Ser Ser Pro Ala Ala Arg Gln
    1650                1655                1660                
His Cys Ser Ser Pro Ser His Ala Ser Gly Arg Glu Pro Gly Ala Lys
1665                1670                1675                1680
Pro Ser Thr Ala Glu Pro Ser Ser Ser Pro Gln Asp Pro Pro Lys Pro
                1685                1690                1695    
Val Ala Ala His Ser Glu Ser Ser Ser His Lys Pro Arg Pro Gly Pro
            1700                1705                1710        
Asp Pro Gly Pro Pro Lys Thr Lys His Pro Asp Arg Ser Leu Ser Ser
        1715                1720                1725            
Gln Lys Pro Ser Val Gly Ala Thr Lys Gly Lys Glu Pro Ala Thr Gln
    1730                1735                1740                
Ser Leu Gly Gly Ser Ser Arg Glu Gly Lys Gly His Ser Lys Ser Gly
1745                1750                1755                1760
Pro Asp Val Phe Pro Ala Thr Pro Gly Ser Gln Asn Lys Ala Ser Asp
                1765                1770                1775    
Gly Ile Gly Gln Gly Glu Gly Gly Pro Ser Val Pro Leu His Thr Asp
            1780                1785                1790        
Arg Ala Pro Leu Asp Ala Lys Pro Gln Pro Thr Ser Gly Gly Arg Pro
        1795                1800                1805            
Leu Glu Val Leu Glu Lys Pro Val His Leu Pro Arg Pro Gly His Pro
    1810                1815                1820                
Gly Pro Ser Glu Pro Ala Asp Gln Lys Leu Ser Ala Val Gly Glu Lys
1825                1830                1835                1840
Gln Thr Leu Ser Pro Lys His Pro Lys Pro Ser Thr Val Lys Asp Cys
                1845                1850                1855    
Pro Thr Leu Cys Lys Gln Thr Asp Asn Arg Gln Thr Asp Lys Ser Pro
            1860                1865                1870        
Ser Gln Pro Ala Ala Asn Thr Asp Arg Arg Ala Glu Gly Lys Lys Cys
        1875                1880                1885            
Thr Glu Ala Leu Tyr Ala Pro Ala Glu Gly Asp Lys Leu Glu Ala Gly
    1890                1895                1900                
Leu Ser Phe Val His Ser Glu Asn Arg Leu Lys Gly Ala Glu Arg Pro
1905                1910                1915                1920
Ala Ala Gly Val Gly Lys Gly Phe Pro Glu Ala Arg Gly Lys Gly Pro
                1925                1930                1935    
Gly Pro Gln Lys Pro Pro Thr Glu Ala Asp Lys Pro Asn Gly Met Lys
            1940                1945                1950        
Arg Ser Pro Ser Ala Thr Gly Gln Ser Ser Phe Arg Ser Thr Ala Leu
        1955                1960                1965            
Pro Glu Lys Ser Leu Ser Cys Ser Ser Ser Phe Pro Glu Thr Arg Ala
    1970                1975                1980                
Gly Val Arg Glu Ala Ser Ala Ala Ser Ser Asp Thr Ser Ser Ala Lys
1985                1990                1995                2000
Ala Ala Gly Gly Met Leu Glu Leu Pro Ala Pro Ser Asn Arg Asp His
                2005                2010                2015    
Arg Lys Ala Gln Pro Ala Gly Glu Gly Arg Thr His Met Thr Lys Ser
            2020                2025                2030        
Asp Ser Leu Pro Ser Phe Arg Val Ser Thr Leu Pro Leu Glu Ser His
        2035                2040                2045            
His Pro Asp Pro Asn Thr Met Gly Gly Ala Ser His Arg Asp Arg Ala
    2050                2055                2060                
Leu Ser Val Thr Ala Thr Val Gly Glu Thr Lys Gly Lys Asp Pro Ala
2065                2070                2075                2080
Pro Ala Gln Pro Pro Pro Ala Arg Lys Gln Asn Val Gly Arg Asp Val
                2085                2090                2095    
Thr Lys Pro Ser Pro Ala Pro Asn Thr Asp Arg Pro Ile Ser Leu Ser
            2100                2105                2110        
Asn Glu Lys Asp Phe Val Val Arg Gln Arg Arg Gly Lys Glu Ser Leu
        2115                2120                2125            
Arg Ser Ser Pro His Lys Lys Ala Leu
    2130                2135        


<210> 7091
<211> 1270
<212> PRT
<213> Homo sapiens

<400> 7091
Met Asp Ser Leu Glu Glu Pro Gln Lys Lys Val Phe Lys Ala Arg Lys
 1               5                  10                  15      
Thr Met Arg Val Ser Asp Arg Gln Gln Leu Glu Ala Val Tyr Lys Val
            20                  25                  30          
Lys Glu Glu Leu Leu Lys Thr Asp Val Lys Leu Leu Asn Gly Asn His
        35                  40                  45              
Glu Asn Gly Asp Leu Asp Pro Thr Ser Pro Leu Glu Asn Met Asp Tyr
    50                  55                  60                  
Ile Lys Asp Lys Glu Glu Val Asn Gly Ile Glu Glu Ile Cys Phe Asp
65                  70                  75                  80  
Pro Glu Gly Ser Lys Ala Glu Trp Lys Glu Thr Pro Cys Ile Leu Ser
                85                  90                  95      
Val Asn Val Lys Asn Lys Gln Asp Asp Asp Leu Asn Cys Glu Pro Leu
            100                 105                 110         
Ser Pro His Asn Ile Thr Pro Glu Pro Val Ser Lys Leu Pro Ala Glu
        115                 120                 125             
Pro Val Ser Gly Asp Pro Ala Pro Gly Asp Leu Asp Ala Gly Asp Pro
    130                 135                 140                 
Ala Ser Gly Val Leu Ala Ser Gly Asp Ser Thr Ser Gly Asp Pro Thr
145                 150                 155                 160 
Ser Ser Glu Pro Ser Ser Ser Asp Ala Ala Ser Gly Asp Ala Thr Ser
                165                 170                 175     
Gly Asp Ala Pro Ser Gly Asp Val Ser Pro Gly Asp Ala Thr Ser Gly
            180                 185                 190         
Asp Ala Thr Ala Asp Asp Leu Ser Ser Gly Asp Pro Thr Ser Ser Asp
        195                 200                 205             
Pro Ile Pro Gly Glu Pro Val Pro Val Glu Pro Ile Ser Gly Asp Cys
    210                 215                 220                 
Ala Ala Asp Asp Ile Ala Ser Ser Glu Ile Thr Ser Val Asp Leu Ala
225                 230                 235                 240 
Ser Gly Ala Pro Ala Ser Thr Asp Pro Ala Ser Asp Asp Leu Ala Ser
                245                 250                 255     
Gly Asp Leu Ser Ser Ser Glu Leu Ala Ser Asp Asp Leu Ala Thr Gly
            260                 265                 270         
Glu Leu Ala Ser Asp Glu Leu Thr Ser Glu Ser Thr Phe Asp Arg Thr
        275                 280                 285             
Phe Glu Pro Lys Ser Val Pro Val Cys Glu Pro Val Pro Glu Ile Asp
    290                 295                 300                 
Asn Ile Glu Pro Ser Ser Asn Lys Asp Asp Asp Phe Leu Glu Lys Asn
305                 310                 315                 320 
Gly Ala Asp Glu Lys Leu Glu Gln Ile Gln Ser Lys Asp Ser Leu Asp
                325                 330                 335     
Glu Lys Asn Lys Ala Asp Asn Asn Ile Asp Ala Ile Glu Glu Thr Leu
            340                 345                 350         
Glu Thr Asp Asp Thr Thr Ile Cys Ser Asp Arg Pro Pro Glu Asn Glu
        355                 360                 365             
Lys Lys Val Glu Glu Asp Ile Ile Thr Glu Leu Ala Leu Gly Glu Asp
    370                 375                 380                 
Ala Ile Ser Ser Ser Met Glu Ile Asp Gln Gly Glu Lys Asn Glu Asp
385                 390                 395                 400 
Glu Thr Ser Ala Asp Leu Val Glu Thr Ile Asn Glu Asn Val Ile Glu
                405                 410                 415     
Asp Asn Lys Ser Glu Asn Ile Leu Glu Asn Thr Asp Ser Met Glu Thr
            420                 425                 430         
Asp Glu Ile Ile Pro Ile Leu Glu Lys Leu Ala Pro Ser Glu Asp Glu
        435                 440                 445             
Leu Thr Cys Phe Ser Lys Thr Ser Leu Leu Pro Ile Asp Glu Thr Asn
    450                 455                 460                 
Pro Asp Leu Glu Glu Lys Met Glu Ser Ser Phe Gly Ser Pro Ser Lys
465                 470                 475                 480 
Gln Glu Ser Ser Glu Ser Leu Pro Lys Glu Ala Phe Leu Val Leu Ser
                485                 490                 495     
Asp Glu Glu Asp Ile Ser Gly Glu Lys Asp Glu Ser Glu Val Ile Ser
            500                 505                 510         
Gln Asn Glu Thr Cys Ser Pro Ala Glu Val Glu Ser Asn Glu Lys Asp
        515                 520                 525             
Asn Lys Pro Glu Glu Glu Glu Gln Val Ile His Glu Asp Asp Glu Arg
    530                 535                 540                 
Pro Ser Glu Lys Asn Glu Phe Ser Arg Arg Lys Arg Ser Lys Ser Glu
545                 550                 555                 560 
Asp Met Asp Asn Val Gln Ser Lys Arg Arg Arg Tyr Met Glu Glu Glu
                565                 570                 575     
Tyr Glu Ala Glu Phe Gln Val Lys Ile Thr Ala Lys Gly Asp Ile Asn
            580                 585                 590         
Gln Lys Leu Gln Lys Val Ile Gln Trp Leu Leu Glu Glu Lys Leu Cys
        595                 600                 605             
Ala Leu Gln Cys Ala Val Phe Asp Lys Thr Leu Ala Glu Leu Lys Thr
    610                 615                 620                 
Arg Val Glu Lys Ile Glu Cys Asn Lys Arg His Lys Thr Val Leu Thr
625                 630                 635                 640 
Glu Leu Gln Ala Lys Ile Ala Arg Leu Thr Lys Arg Phe Glu Ala Ala
                645                 650                 655     
Lys Glu Asp Leu Lys Lys Arg His Glu His Pro Pro Asn Pro Pro Val
            660                 665                 670         
Ser Pro Gly Lys Thr Val Asn Asp Val Asn Ser Asn Asn Asn Met Ser
        675                 680                 685             
Tyr Arg Asn Ala Gly Thr Val Arg Gln Met Leu Glu Ser Lys Arg Asn
    690                 695                 700                 
Val Ser Glu Ser Ala Pro Pro Ser Phe Gln Thr Pro Val Asn Thr Val
705                 710                 715                 720 
Ser Ser Thr Asn Leu Val Thr Pro Pro Ala Val Val Ser Ser Gln Pro
                725                 730                 735     
Lys Leu Gln Thr Pro Val Thr Ser Gly Ser Leu Thr Ala Thr Ser Val
            740                 745                 750         
Leu Pro Ala Pro Asn Thr Ala Thr Val Val Ala Thr Thr Gln Val Pro
        755                 760                 765             
Ser Gly Asn Pro Gln Pro Thr Ile Ser Leu Gln Pro Leu Pro Val Ile
    770                 775                 780                 
Leu His Val Pro Val Ala Val Ser Ser Gln Pro Gln Leu Leu Gln Ser
785                 790                 795                 800 
His Pro Gly Thr Leu Val Thr Asn Gln Pro Ser Gly Asn Val Glu Phe
                805                 810                 815     
Ile Ser Val Gln Ser Pro Pro Thr Val Ser Gly Leu Thr Lys Asn Pro
            820                 825                 830         
Val Ser Leu Pro Ser Leu Pro Asn Pro Thr Lys Pro Asn Asn Val Pro
        835                 840                 845             
Ser Val Pro Ser Pro Ser Ile Gln Arg Asn Pro Thr Ala Ser Ala Ala
    850                 855                 860                 
Pro Leu Gly Thr Thr Leu Ala Val Gln Ala Val Pro Thr Ala His Ser
865                 870                 875                 880 
Ile Val Gln Ala Thr Arg Thr Ser Leu Pro Thr Val Gly Pro Ser Gly
                885                 890                 895     
Leu Tyr Ser Pro Ser Thr Asn Arg Gly Pro Ile Gln Met Lys Ile Pro
            900                 905                 910         
Ile Ser Ala Phe Ser Thr Ser Ser Ala Ala Glu Gln Asn Ser Asn Thr
        915                 920                 925             
Thr Pro Arg Ile Glu Asn Gln Thr Asn Lys Thr Ile Asp Ala Ser Val
    930                 935                 940                 
Ser Lys Lys Ala Ala Asp Ser Thr Ser Gln Cys Gly Lys Ala Thr Gly
945                 950                 955                 960 
Ser Asp Ser Ser Gly Val Ile Asp Leu Thr Met Asp Asp Glu Glu Ser
                965                 970                 975     
Gly Ala Ser Gln Asp Pro Lys Lys Leu Asn His Thr Pro Val Ser Thr
            980                 985                 990         
Met Ser Ser Ser Gln Pro Val Ser Arg Pro Leu Gln Pro Ile Gln Pro
        995                 1000                1005            
Ala Pro Pro Leu Gln Pro Ser Gly Val Pro Thr Ser Gly Pro Ser Gln
    1010                1015                1020                
Thr Thr Ile His Leu Leu Pro Thr Ala Pro Thr Thr Val Asn Val Thr
1025                1030                1035                1040
His Arg Pro Val Thr Gln Val Thr Thr Arg Leu Pro Val Pro Arg Ala
                1045                1050                1055    
Pro Ala Asn His Gln Val Val Tyr Thr Thr Leu Pro Ala Pro Pro Ala
            1060                1065                1070        
Gln Ala Pro Leu Arg Gly Thr Val Met Gln Ala Pro Ala Val Arg Gln
        1075                1080                1085            
Val Asn Pro Gln Asn Ser Val Thr Val Arg Val Pro Gln Thr Thr Thr
    1090                1095                1100                
Tyr Val Val Asn Asn Gly Leu Thr Leu Gly Ser Thr Gly Pro Gln Leu
1105                1110                1115                1120
Thr Val His His Arg Pro Pro Gln Val His Thr Glu Pro Pro Arg Pro
                1125                1130                1135    
Val His Pro Ala Pro Leu Pro Glu Ala Pro Gln Pro Gln Arg Leu Pro
            1140                1145                1150        
Pro Glu Ala Ala Ser Thr Ser Leu Pro Gln Lys Pro His Leu Lys Leu
        1155                1160                1165            
Ala Arg Val Gln Ser Gln Asn Gly Ile Val Leu Ser Trp Ser Val Leu
    1170                1175                1180                
Glu Val Asp Arg Ser Cys Ala Thr Val Asp Ser Tyr His Leu Tyr Ala
1185                1190                1195                1200
Tyr His Glu Glu Pro Ser Ala Thr Val Pro Ser Gln Trp Lys Lys Ile
                1205                1210                1215    
Gly Glu Val Lys Ala Leu Pro Leu Pro Met Ala Cys Thr Leu Thr Gln
            1220                1225                1230        
Phe Val Ser Gly Ser Lys Tyr Tyr Phe Ala Val Arg Ala Lys Asp Ile
        1235                1240                1245            
Tyr Gly Arg Phe Gly Pro Phe Cys Asp Pro Gln Ser Thr Asp Val Ile
    1250                1255                1260                
Ser Ser Thr Gln Ser Ser
1265                1270


<210> 7092
<211> 472
<212> PRT
<213> Homo sapiens

<400> 7092
Met Thr Ser Glu Asn Gln Glu Lys Val Lys Ala Leu Leu Arg Asp Leu
 1               5                  10                  15      
Gln Glu Gln Asp Ala Asp Ala Gly Ser Glu Arg Gly Leu Ser Gly Glu
            20                  25                  30          
Glu Glu Asp Asp Glu Pro Asp Cys Cys Asn Asp Glu Arg Tyr Trp Pro
        35                  40                  45              
Ala Gly Gln Glu Pro Ser Leu Val Pro Asp Leu Asp Pro Leu Glu Tyr
    50                  55                  60                  
Ala Gly Leu Ala Ser Val Glu Pro Tyr Val Pro Glu Phe Thr Val Ser
65                  70                  75                  80  
Pro Phe Ala Val Gln Lys Leu Ser Arg Tyr Gly Phe Asn Thr Glu Arg
                85                  90                  95      
Cys Gln Ala Val Leu Arg Met Cys Asp Gly Asp Val Gly Ala Ser Leu
            100                 105                 110         
Glu His Leu Leu Thr Gln Cys Phe Ser Glu Thr Phe Gly Glu Arg Met
        115                 120                 125             
Lys Ile Ser Glu Ala Val Asn Gln Ile Ser Leu Asp Glu Cys Met Glu
    130                 135                 140                 
Gln Arg Gln Glu Glu Ala Phe Ala Leu Lys Ser Ile Cys Gly Glu Lys
145                 150                 155                 160 
Phe Ile Glu Arg Ile Gln Asn Arg Val Trp Thr Ile Gly Leu Glu Leu
                165                 170                 175     
Glu Tyr Leu Thr Ser Arg Phe Arg Lys Ser Lys Pro Lys Glu Ser Thr
            180                 185                 190         
Lys Asn Val Gln Glu Asn Ser Leu Glu Ile Cys Lys Phe Tyr Leu Lys
        195                 200                 205             
Gly Asn Cys Lys Phe Gly Ser Lys Cys Arg Phe Lys His Glu Val Pro
    210                 215                 220                 
Pro Asn Gln Ile Val Gly Arg Ile Glu Arg Ser Val Asp Asp Ser His
225                 230                 235                 240 
Leu Asn Ala Ile Glu Asp Ala Ser Phe Leu Tyr Glu Leu Glu Ile Arg
                245                 250                 255     
Phe Ser Lys Asp His Lys Tyr Pro Tyr Gln Ala Pro Leu Val Ala Phe
            260                 265                 270         
Tyr Ser Thr Asn Glu Asn Leu Pro Leu Ala Cys Arg Leu His Ile Ser
        275                 280                 285             
Glu Phe Leu Tyr Asp Lys Ala Leu Thr Phe Ala Glu Thr Ser Glu Pro
    290                 295                 300                 
Val Val Tyr Ser Leu Ile Thr Leu Leu Glu Glu Glu Ser Glu Ile Val
305                 310                 315                 320 
Lys Leu Leu Thr Asn Thr His His Lys Tyr Ser Asp Pro Pro Val Asn
                325                 330                 335     
Phe Leu Pro Val Pro Ser Arg Thr Arg Ile Asn Asn Pro Ala Cys His
            340                 345                 350         
Lys Thr Val Ile Pro Asn Asn Ser Phe Val Ser Asn Gln Ile Pro Glu
        355                 360                 365             
Val Glu Lys Ala Ser Glu Ser Glu Glu Ser Asp Glu Asp Asp Gly Pro
    370                 375                 380                 
Ala Pro Val Ile Val Glu Asn Glu Ser Tyr Val Asn Leu Lys Lys Lys
385                 390                 395                 400 
Ile Ser Lys Arg Tyr Asp Trp Gln Ala Lys Ser Val His Ala Glu Asn
                405                 410                 415     
Gly Lys Ile Cys Lys Gln Phe Arg Met Lys Gln Ala Ser Arg Gln Phe
            420                 425                 430         
Gln Ser Ile Leu Gln Glu Arg Gln Ser Leu Pro Ala Trp Glu Glu Arg
        435                 440                 445             
Glu Thr Ile Leu Asn Leu Leu Arg Lys His Gln Val Val Val Ile Ser
    450                 455                 460                 
Gly Met Thr Gly Thr Tyr Leu Phe
465                 470         


<210> 7093
<211> 1386
<212> PRT
<213> Homo sapiens

<400> 7093
Met Ser Ser Ser Val Arg Arg Lys Gly Lys Pro Gly Lys Gly Gly Gly
 1               5                  10                  15      
Lys Gly Ser Ser Arg Gly Gly Arg Gly Gly Arg Ser His Ala Ser Lys
            20                  25                  30          
Ser His Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
        35                  40                  45              
Gly Asn Arg Lys Ala Ser Ser Arg Ile Trp Asp Asp Gly Asp Asp Phe
    50                  55                  60                  
Cys Ile Phe Ser Glu Ser Arg Arg Pro Ser Arg Pro Ser Asn Ser Asn
65                  70                  75                  80  
Ile Ser Lys Gly Glu Ser Arg Pro Lys Trp Lys Pro Lys Ala Lys Val
                85                  90                  95      
Pro Leu Gln Thr Leu His Met Thr Ser Glu Asn Gln Glu Lys Val Lys
            100                 105                 110         
Ala Leu Leu Arg Asp Leu Gln Glu Gln Asp Ala Asp Ala Gly Ser Glu
        115                 120                 125             
Arg Gly Leu Ser Gly Glu Glu Glu Asp Asp Glu Pro Asp Cys Cys Asn
    130                 135                 140                 
Asp Glu Arg Tyr Trp Pro Ala Gly Gln Glu Pro Ser Leu Val Pro Asp
145                 150                 155                 160 
Leu Asp Pro Leu Glu Tyr Ala Gly Leu Ala Ser Val Glu Pro Tyr Val
                165                 170                 175     
Pro Glu Phe Thr Val Ser Pro Phe Ala Val Gln Lys Leu Ser Arg Tyr
            180                 185                 190         
Gly Phe Asn Thr Glu Arg Cys Gln Ala Val Leu Arg Met Cys Asp Gly
        195                 200                 205             
Asp Val Gly Ala Ser Leu Glu His Leu Leu Thr Gln Cys Phe Ser Glu
    210                 215                 220                 
Thr Phe Gly Glu Arg Met Lys Ile Ser Glu Ala Val Asn Gln Ile Ser
225                 230                 235                 240 
Leu Asp Glu Cys Met Glu Gln Arg Gln Glu Glu Ala Phe Ala Leu Lys
                245                 250                 255     
Ser Ile Cys Gly Glu Lys Phe Ile Glu Arg Ile Gln Asn Arg Val Trp
            260                 265                 270         
Thr Ile Gly Leu Glu Leu Glu Tyr Leu Thr Ser Arg Phe Arg Lys Ser
        275                 280                 285             
Lys Pro Lys Glu Ser Thr Lys Asn Val Gln Glu Asn Ser Leu Glu Ile
    290                 295                 300                 
Cys Lys Phe Tyr Leu Lys Gly Asn Cys Lys Phe Gly Ser Lys Cys Arg
305                 310                 315                 320 
Phe Lys His Glu Val Pro Pro Asn Gln Ile Val Gly Arg Ile Glu Arg
                325                 330                 335     
Ser Val Asp Asp Ser His Leu Asn Ala Ile Glu Asp Ala Ser Phe Leu
            340                 345                 350         
Tyr Glu Leu Glu Ile Arg Phe Ser Lys Asp His Lys Tyr Pro Tyr Gln
        355                 360                 365             
Ala Pro Leu Val Ala Phe Tyr Ser Thr Asn Glu Asn Leu Pro Leu Ala
    370                 375                 380                 
Cys Arg Leu His Ile Ser Glu Phe Leu Tyr Asp Lys Ala Leu Thr Phe
385                 390                 395                 400 
Ala Glu Thr Ser Glu Pro Val Val Tyr Ser Leu Ile Thr Leu Leu Glu
                405                 410                 415     
Glu Glu Ser Glu Ile Val Lys Leu Leu Thr Asn Thr His His Lys Tyr
            420                 425                 430         
Ser Asp Pro Pro Val Asn Phe Leu Pro Val Pro Ser Arg Thr Arg Ile
        435                 440                 445             
Asn Asn Pro Ala Cys His Lys Thr Val Ile Pro Asn Asn Ser Phe Val
    450                 455                 460                 
Ser Asn Gln Ile Pro Glu Val Glu Lys Ala Ser Glu Ser Glu Glu Ser
465                 470                 475                 480 
Asp Glu Asp Asp Gly Pro Ala Pro Val Ile Val Glu Asn Glu Ser Tyr
                485                 490                 495     
Val Asn Leu Lys Lys Lys Ile Ser Lys Arg Tyr Asp Trp Gln Ala Lys
            500                 505                 510         
Ser Val His Ala Glu Asn Gly Lys Ile Cys Lys Gln Phe Arg Met Lys
        515                 520                 525             
Gln Ala Ser Arg Gln Phe Gln Ser Ile Leu Gln Glu Arg Gln Ser Leu
    530                 535                 540                 
Pro Ala Trp Glu Glu Arg Glu Thr Ile Leu Asn Leu Leu Arg Lys His
545                 550                 555                 560 
Gln Val Val Val Ile Ser Gly Met Thr Gly Cys Gly Lys Thr Thr Gln
                565                 570                 575     
Ile Pro Gln Phe Ile Leu Asp Asp Ser Leu Asn Gly Pro Pro Glu Lys
            580                 585                 590         
Val Ala Asn Ile Ile Cys Thr Gln Pro Arg Arg Ile Ser Ala Ile Ser
        595                 600                 605             
Val Ala Glu Arg Val Ala Lys Glu Arg Ala Glu Arg Val Gly Leu Thr
    610                 615                 620                 
Val Gly Tyr Gln Ile Arg Leu Glu Ser Val Lys Ser Ser Ala Thr Arg
625                 630                 635                 640 
Leu Leu Tyr Cys Thr Thr Gly Val Leu Leu Arg Arg Leu Glu Gly Asp
                645                 650                 655     
Thr Ala Leu Gln Gly Val Ser His Ile Ile Val Asp Glu Val His Glu
            660                 665                 670         
Arg Thr Glu Glu Ser Asp Phe Leu Leu Leu Val Leu Lys Asp Ile Val
        675                 680                 685             
Ser Gln Arg Pro Gly Leu Gln Val Ile Leu Met Ser Ala Thr Leu Asn
    690                 695                 700                 
Ala Glu Leu Phe Ser Asp Tyr Phe Asn Ser Cys Pro Val Ile Thr Ile
705                 710                 715                 720 
Pro Gly Arg Thr Phe Pro Val Asp Gln Phe Phe Leu Glu Asp Ala Ile
                725                 730                 735     
Ala Val Thr Arg Tyr Val Leu Gln Asp Gly Ser Pro Tyr Met Arg Ser
            740                 745                 750         
Met Lys Gln Ile Ser Lys Glu Lys Leu Lys Ala Arg Arg Asn Arg Thr
        755                 760                 765             
Ala Phe Glu Glu Val Glu Glu Asp Leu Arg Leu Ser Leu His Leu Gln
    770                 775                 780                 
Asp Gln Asp Ser Val Lys Asp Ala Val Pro Asp Gln Gln Leu Asp Phe
785                 790                 795                 800 
Lys Gln Leu Leu Ala Arg Tyr Lys Gly Val Ser Lys Ser Val Ile Lys
                805                 810                 815     
Thr Met Ser Ile Met Asp Phe Glu Lys Val Asn Leu Glu Leu Ile Glu
            820                 825                 830         
Ala Leu Leu Glu Trp Ile Val Asp Gly Lys His Ser Tyr Pro Pro Gly
        835                 840                 845             
Ala Ile Leu Val Phe Leu Pro Gly Leu Ala Glu Ile Lys Met Leu Tyr
    850                 855                 860                 
Glu Gln Leu Gln Ser Asn Ser Leu Phe Asn Asn Arg Arg Ser Asn Arg
865                 870                 875                 880 
Cys Val Ile His Pro Leu His Ser Ser Leu Ser Ser Glu Glu Gln Gln
                885                 890                 895     
Ala Val Phe Val Lys Pro Pro Ala Gly Val Thr Lys Ile Ile Ile Ser
            900                 905                 910         
Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile Asp Asp Val Val Tyr Val
        915                 920                 925             
Ile Asp Ser Gly Lys Met Lys Glu Lys Arg Tyr Asp Ala Ser Lys Gly
    930                 935                 940                 
Met Glu Ser Leu Glu Asp Thr Phe Val Ser Gln Ala Asn Ala Leu Gln
945                 950                 955                 960 
Arg Lys Gly Arg Ala Gly Arg Val Ala Ser Gly Val Cys Phe His Leu
                965                 970                 975     
Phe Thr Ser His His Tyr Asn His Gln Leu Leu Lys Gln Gln Leu Pro
            980                 985                 990         
Glu Ile Gln Arg Val Pro Leu Glu Gln Leu Cys Leu Arg Ile Lys Ile
        995                 1000                1005            
Leu Glu Met Phe Ser Ala His Asn Leu Gln Ser Val Phe Ser Arg Leu
    1010                1015                1020                
Ile Glu Pro Pro His Thr Asp Ser Leu Arg Ala Ser Lys Ile Arg Leu
1025                1030                1035                1040
Arg Asp Leu Gly Ala Leu Thr Pro Asp Glu Arg Leu Thr Pro Leu Gly
                1045                1050                1055    
Tyr His Leu Ala Ser Leu Pro Val Asp Val Arg Ile Gly Lys Leu Met
            1060                1065                1070        
Leu Phe Gly Ser Ile Phe Arg Cys Leu Asp Pro Ala Leu Thr Ile Ala
        1075                1080                1085            
Ala Ser Leu Ala Phe Lys Ser Pro Phe Val Ser Pro Trp Asp Lys Lys
    1090                1095                1100                
Glu Glu Ala Asn Gln Lys Lys Leu Glu Phe Ala Phe Ala Asn Ser Asp
1105                1110                1115                1120
Tyr Leu Ala Leu Leu Gln Ala Tyr Lys Gly Trp Gln Leu Ser Thr Lys
                1125                1130                1135    
Glu Gly Val Arg Ala Ser Tyr Asn Tyr Cys Arg Gln Asn Phe Leu Ser
            1140                1145                1150        
Gly Arg Val Leu Gln Glu Met Ala Ser Leu Lys Arg Gln Phe Thr Glu
        1155                1160                1165            
Leu Leu Ser Asp Ile Gly Phe Ala Arg Glu Gly Leu Arg Ala Arg Glu
    1170                1175                1180                
Ile Glu Lys Arg Ala Gln Gly Gly Asp Gly Val Leu Asp Ala Thr Gly
1185                1190                1195                1200
Glu Glu Ala Asn Ser Asn Ala Glu Asn Pro Lys Leu Ile Ser Ala Met
                1205                1210                1215    
Leu Cys Ala Ala Leu Tyr Pro Asn Val Val Gln Val Lys Ser Pro Glu
            1220                1225                1230        
Gly Lys Phe Gln Lys Thr Ser Thr Gly Ala Val Arg Met Gln Pro Lys
        1235                1240                1245            
Ser Ala Glu Leu Lys Phe Val Thr Lys Asn Asp Gly Tyr Val His Ile
    1250                1255                1260                
His Pro Ser Ser Val Asn Tyr Gln Val Arg His Phe Asp Ser Pro Tyr
1265                1270                1275                1280
Leu Leu Tyr His Glu Lys Ile Lys Thr Ser Arg Val Phe Ile Arg Asp
                1285                1290                1295    
Cys Ser Met Val Ser Val Tyr Pro Leu Val Leu Phe Gly Gly Gly Gln
            1300                1305                1310        
Val Asn Val Gln Leu Gln Arg Gly Glu Phe Val Val Ser Leu Asp Asp
        1315                1320                1325            
Gly Trp Ile Arg Phe Val Ala Ala Ser His Gln Val Ala Glu Leu Val
    1330                1335                1340                
Lys Glu Leu Arg Cys Glu Leu Asp Gln Leu Leu Gln Asp Lys Ile Lys
1345                1350                1355                1360
Asn Pro Ser Ile Asp Leu Cys Thr Cys Pro Arg Gly Ser Arg Ile Ile
                1365                1370                1375    
Ser Thr Ile Val Lys Leu Val Thr Thr Gln
            1380                1385    


<210> 7094
<211> 522
<212> PRT
<213> Homo sapiens

<400> 7094
Met Ala Ala Thr Ala Ala Ala Val Val Ala Glu Glu Asp Thr Glu Leu
 1               5                  10                  15      
Arg Asp Leu Leu Val Gln Thr Leu Glu Asn Ser Gly Val Leu Asn Arg
            20                  25                  30          
Ile Lys Ala Glu Leu Arg Ala Ala Val Phe Leu Ala Leu Glu Glu Gln
        35                  40                  45              
Glu Lys Val Glu Val Lys Thr Leu Val Glu Phe Leu Ile Asp Asn Cys
    50                  55                  60                  
Phe Glu Ile Phe Gly Glu Asn Ile Pro Val His Ser Ser Ile Thr Ser
65                  70                  75                  80  
Asp Asp Ser Leu Glu His Thr Asp Ser Ser Asp Val Ser Thr Leu Gln
                85                  90                  95      
Asn Asp Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn Ser
            100                 105                 110         
Ser Ser Gly Ile Ser Ser Pro Ser Arg Gln Pro Gln Val Pro Met Ala
        115                 120                 125             
Thr Ala Ala Gly Leu Asp Ser Ala Gly Pro Gln Asp Ala Arg Glu Val
    130                 135                 140                 
Ser Pro Glu Pro Ile Val Ser Thr Val Ala Arg Leu Lys Ser Ser Leu
145                 150                 155                 160 
Ala Gln Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser Ser Gln
                165                 170                 175     
Glu Cys Leu Glu Ser Arg Val Thr Asn Gln Thr Leu Thr Lys Ser Glu
            180                 185                 190         
Gly Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser Glu Glu
        195                 200                 205             
Ala Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gln Gly Lys
    210                 215                 220                 
Thr Lys Arg Pro Val Asp Leu Lys Ile Lys Asn Leu Ala Pro Gly Ser
225                 230                 235                 240 
Val Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser Ser Leu
                245                 250                 255     
Asp Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser Pro Lys
            260                 265                 270         
Arg Asn Phe Phe Ser Arg His Gln Ser Phe Thr Thr Lys Thr Glu Lys
        275                 280                 285             
Gly Lys Pro Ser Arg Glu Ile Lys Lys His Ser Met Ser Phe Thr Phe
    290                 295                 300                 
Ala Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly Ser Gly
305                 310                 315                 320 
Lys Ser Gln Asp Phe Thr Arg Asp His Val Pro Arg Gly Val Arg Lys
                325                 330                 335     
Glu Ser Gln Leu Ala Gly Arg Ile Val Gln Glu Asn Gly Cys Glu Thr
            340                 345                 350         
His Asn Gln Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala Leu Ser
        355                 360                 365             
Val Asp Asp Val Phe Gln Gly Ala Asp Trp Glu Arg Pro Gly Ser Pro
    370                 375                 380                 
Pro Ser Tyr Glu Glu Ala Met Gln Gly Pro Ala Ala Arg Leu Val Ala
385                 390                 395                 400 
Ser Glu Ser Gln Thr Val Gly Ser Met Thr Val Gly Ser Met Arg Ala
                405                 410                 415     
Arg Met Leu Glu Ala His Cys Leu Leu Pro Pro Leu Pro Pro Ala His
            420                 425                 430         
His Val Glu Asp Ser Arg His Arg Gly Ser Lys Glu Pro Leu Pro Gly
        435                 440                 445             
His Gly Leu Ser Pro Leu Pro Glu Arg Trp Lys Gln Ser Arg Thr Val
    450                 455                 460                 
His Ala Ser Gly Asp Ser Leu Gly His Val Ser Gly Pro Gly Arg Pro
465                 470                 475                 480 
Glu Leu Leu Pro Leu Arg Thr Val Ser Glu Ser Val Gln Arg Asn Lys
                485                 490                 495     
Arg Asp Cys Leu Val Arg Arg Cys Ser Gln Pro Val Phe Glu Ala Asp
            500                 505                 510         
Gln Phe Gln Tyr Ala Lys Glu Ser Tyr Ile
        515                 520         


<210> 7095
<211> 553
<212> PRT
<213> Homo sapiens

<400> 7095
Met Gly Ala Leu Glu Met Gln Asp Glu Glu Asp Arg Ile Glu Ala Leu
 1               5                  10                  15      
Lys Gln Val Ala Asp Lys Leu Pro Arg Pro Asn Leu Leu Leu Leu Lys
            20                  25                  30          
His Leu Val Tyr Val Leu His Leu Ile Ser Lys Asn Ser Glu Val Asn
        35                  40                  45              
Arg Met Asp Ser Ser Asn Leu Ala Ile Cys Ile Gly Pro Asn Met Leu
    50                  55                  60                  
Thr Leu Glu Asn Asp Gln Ser Leu Ser Phe Glu Ala Gln Lys Asp Leu
65                  70                  75                  80  
Asn Asn Lys Val Lys Thr Leu Val Glu Phe Leu Ile Asp Asn Cys Phe
                85                  90                  95      
Glu Ile Phe Gly Glu Asn Ile Pro Val His Ser Ser Ile Thr Ser Asp
            100                 105                 110         
Asp Ser Leu Glu His Thr Asp Ser Ser Asp Val Ser Thr Leu Gln Asn
        115                 120                 125             
Asp Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn Ser Ser
    130                 135                 140                 
Ser Gly Ile Ser Ser Pro Ser Arg Gln Pro Gln Val Pro Met Ala Thr
145                 150                 155                 160 
Ala Ala Gly Leu Asp Ser Ala Gly Pro Gln Asp Ala Arg Glu Val Ser
                165                 170                 175     
Pro Glu Pro Ile Val Ser Thr Val Ala Arg Leu Lys Ser Ser Leu Ala
            180                 185                 190         
Gln Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser Ser Gln Glu
        195                 200                 205             
Cys Leu Glu Ser Arg Val Thr Asn Gln Thr Leu Thr Lys Ser Glu Gly
    210                 215                 220                 
Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser Glu Glu Ala
225                 230                 235                 240 
Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gln Gly Lys Thr
                245                 250                 255     
Lys Arg Pro Val Asp Leu Lys Ile Lys Asn Leu Ala Pro Gly Ser Val
            260                 265                 270         
Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser Ser Leu Asp
        275                 280                 285             
Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser Pro Lys Arg
    290                 295                 300                 
Asn Phe Phe Ser Arg His Gln Ser Phe Thr Thr Lys Thr Glu Lys Gly
305                 310                 315                 320 
Lys Pro Ser Arg Glu Ile Lys Lys His Ser Met Ser Phe Thr Phe Ala
                325                 330                 335     
Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly Ser Gly Lys
            340                 345                 350         
Ser Gln Asp Phe Thr Arg Asp His Val Pro Arg Gly Val Arg Lys Glu
        355                 360                 365             
Ser Gln Leu Ala Gly Arg Ile Val Gln Glu Asn Gly Cys Glu Thr His
    370                 375                 380                 
Asn Gln Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala Leu Ser Val
385                 390                 395                 400 
Asp Asp Val Phe Gln Gly Ala Asp Trp Glu Arg Pro Gly Ser Pro Pro
                405                 410                 415     
Ser Tyr Glu Glu Ala Met Gln Gly Pro Ala Ala Arg Leu Val Ala Ser
            420                 425                 430         
Glu Ser Gln Thr Val Gly Ser Met Thr Val Gly Ser Met Arg Ala Arg
        435                 440                 445             
Met Leu Glu Ala His Cys Leu Leu Pro Pro Leu Pro Pro Ala His His
    450                 455                 460                 
Val Glu Asp Ser Arg His Arg Gly Ser Lys Glu Pro Leu Pro Gly His
465                 470                 475                 480 
Gly Leu Ser Pro Leu Pro Glu Arg Trp Lys Gln Ser Arg Thr Val His
                485                 490                 495     
Ala Ser Gly Asp Ser Leu Gly His Val Ser Gly Pro Gly Arg Pro Glu
            500                 505                 510         
Leu Leu Pro Leu Arg Thr Val Ser Glu Ser Val Gln Arg Asn Lys Arg
        515                 520                 525             
Asp Cys Leu Val Arg Arg Cys Ser Gln Pro Val Phe Glu Ala Asp Gln
    530                 535                 540                 
Phe Gln Tyr Ala Lys Glu Ser Tyr Ile
545                 550             


<210> 7096
<211> 731
<212> PRT
<213> Homo sapiens

<400> 7096
Met Lys Leu Arg Ser Ser His Asn Ala Ser Lys Thr Leu Asn Ala Asn
 1               5                  10                  15      
Asn Met Glu Thr Leu Ile Glu Cys Gln Ser Glu Gly Asp Ile Lys Glu
            20                  25                  30          
His Pro Leu Leu Ala Ser Cys Glu Ser Glu Asp Ser Ile Cys Gln Leu
        35                  40                  45              
Ile Glu Val Lys Lys Arg Lys Lys Val Leu Ser Trp Pro Phe Leu Met
    50                  55                  60                  
Arg Arg Leu Ser Pro Ala Ser Asp Phe Ser Gly Ala Leu Glu Thr Asp
65                  70                  75                  80  
Leu Lys Ala Ser Leu Phe Asp Gln Pro Leu Ser Ile Ile Cys Gly Asp
                85                  90                  95      
Ser Asp Thr Leu Pro Arg Pro Ile Gln Asp Ile Leu Thr Ile Leu Cys
            100                 105                 110         
Leu Lys Gly Pro Ser Thr Glu Gly Ile Phe Arg Arg Ala Ala Asn Glu
        115                 120                 125             
Lys Ala Arg Lys Glu Leu Lys Glu Glu Leu Asn Ser Gly Asp Ala Val
    130                 135                 140                 
Asp Leu Glu Arg Leu Pro Val His Leu Leu Ala Val Val Phe Lys Asp
145                 150                 155                 160 
Phe Leu Arg Ser Ile Pro Arg Lys Leu Leu Ser Ser Asp Leu Phe Glu
                165                 170                 175     
Glu Trp Met Gly Ala Leu Glu Met Gln Asp Glu Glu Asp Arg Ile Glu
            180                 185                 190         
Ala Leu Lys Gln Val Ala Asp Lys Leu Pro Arg Pro Asn Leu Leu Leu
        195                 200                 205             
Leu Lys His Leu Val Tyr Val Leu His Leu Ile Ser Lys Asn Ser Glu
    210                 215                 220                 
Val Asn Arg Met Asp Ser Ser Asn Leu Ala Ile Cys Ile Gly Pro Asn
225                 230                 235                 240 
Met Leu Thr Leu Glu Asn Asp Gln Ser Leu Ser Phe Glu Ala Gln Lys
                245                 250                 255     
Asp Leu Asn Asn Lys Val Lys Thr Leu Val Glu Phe Leu Ile Asp Asn
            260                 265                 270         
Cys Phe Glu Ile Phe Gly Glu Asn Ile Pro Val His Ser Ser Ile Thr
        275                 280                 285             
Ser Asp Asp Ser Leu Glu His Thr Asp Ser Ser Asp Val Ser Thr Leu
    290                 295                 300                 
Gln Asn Asp Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn
305                 310                 315                 320 
Ser Ser Ser Gly Ile Ser Ser Pro Ser Arg Gln Pro Gln Val Pro Met
                325                 330                 335     
Ala Thr Ala Ala Gly Leu Asp Ser Ala Gly Pro Gln Asp Ala Arg Glu
            340                 345                 350         
Val Ser Pro Glu Pro Ile Val Ser Thr Val Ala Arg Leu Lys Ser Ser
        355                 360                 365             
Leu Ala Gln Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser Ser
    370                 375                 380                 
Gln Glu Cys Leu Glu Ser Arg Val Thr Asn Gln Thr Leu Thr Lys Ser
385                 390                 395                 400 
Glu Gly Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser Glu
                405                 410                 415     
Glu Ala Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gln Gly
            420                 425                 430         
Lys Thr Lys Arg Pro Val Asp Leu Lys Ile Lys Asn Leu Ala Pro Gly
        435                 440                 445             
Ser Val Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser Ser
    450                 455                 460                 
Leu Asp Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser Pro
465                 470                 475                 480 
Lys Arg Asn Phe Phe Ser Arg His Gln Ser Phe Thr Thr Lys Thr Glu
                485                 490                 495     
Lys Gly Lys Pro Ser Arg Glu Ile Lys Lys His Ser Met Ser Phe Thr
            500                 505                 510         
Phe Ala Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly Ser
        515                 520                 525             
Gly Lys Ser Gln Asp Phe Thr Arg Asp His Val Pro Arg Gly Val Arg
    530                 535                 540                 
Lys Glu Ser Gln Leu Ala Gly Arg Ile Val Gln Glu Asn Gly Cys Glu
545                 550                 555                 560 
Thr His Asn Gln Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala Leu
                565                 570                 575     
Ser Val Asp Asp Val Phe Gln Gly Ala Asp Trp Glu Arg Pro Gly Ser
            580                 585                 590         
Pro Pro Ser Tyr Glu Glu Ala Met Gln Gly Pro Ala Ala Arg Leu Val
        595                 600                 605             
Ala Ser Glu Ser Gln Thr Val Gly Ser Met Thr Val Gly Ser Met Arg
    610                 615                 620                 
Ala Arg Met Leu Glu Ala His Cys Leu Leu Pro Pro Leu Pro Pro Ala
625                 630                 635                 640 
His His Val Glu Asp Ser Arg His Arg Gly Ser Lys Glu Pro Leu Pro
                645                 650                 655     
Gly His Gly Leu Ser Pro Leu Pro Glu Arg Trp Lys Gln Ser Arg Thr
            660                 665                 670         
Val His Ala Ser Gly Asp Ser Leu Gly His Val Ser Gly Pro Gly Arg
        675                 680                 685             
Pro Glu Leu Leu Pro Leu Arg Thr Val Ser Glu Ser Val Gln Arg Asn
    690                 695                 700                 
Lys Arg Asp Cys Leu Val Arg Arg Cys Ser Gln Pro Val Phe Glu Ala
705                 710                 715                 720 
Asp Gln Phe Gln Tyr Ala Lys Glu Ser Tyr Ile
                725                 730     


<210> 7097
<211> 542
<212> PRT
<213> Homo sapiens

<400> 7097
Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His
        115                 120                 125             
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr
305                 310                 315                 320 
Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly
                325                 330                 335     
Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val
            340                 345                 350         
Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro
        355                 360                 365             
Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile
    370                 375                 380                 
His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr
385                 390                 395                 400 
Thr Ile Glu Asp Glu Asp Ala Lys Ala Arg Lys Gln Glu Ile Ile Lys
                405                 410                 415     
Thr Thr Glu Gln Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala
            420                 425                 430         
Tyr Ala Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala
        435                 440                 445             
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu
    450                 455                 460                 
Asn Leu Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn
465                 470                 475                 480 
Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile
                485                 490                 495     
Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln
            500                 505                 510         
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn
        515                 520                 525             
Val His Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln
    530                 535                 540         


<210> 7098
<211> 517
<212> PRT
<213> Homo sapiens

<400> 7098
Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His
        115                 120                 125             
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Lys Ser Leu Leu
305                 310                 315                 320 
Asn Lys Lys Ala Asp Gly Val Lys Pro Gln Thr Asn Ser Thr Lys Asn
                325                 330                 335     
Ser Ala Ala Ala Thr Ser Pro Lys Gly Thr Leu Pro Pro Ala Ala Leu
            340                 345                 350         
Glu Pro Gln Thr Thr Val Ile His Asn Pro Val Asp Gly Ile Lys Glu
        355                 360                 365             
Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala Lys Ala
    370                 375                 380                 
Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu Ala Val
385                 390                 395                 400 
Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile Cys Asp Pro Gly Leu
                405                 410                 415     
Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp
            420                 425                 430         
Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala Lys Asn Ser Lys Pro
        435                 440                 445             
Ile His Thr Thr Ile Leu Asn Pro His Val His Val Ile Gly Glu Asp
    450                 455                 460                 
Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln
465                 470                 475                 480 
Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr Arg Val Trp His Arg
                485                 490                 495     
Arg Asp Gly Lys Trp Gln Asn Val His Phe His Cys Ser Gly Ala Pro
            500                 505                 510         
Val Ala Pro Leu Gln
        515         


<210> 7099
<211> 492
<212> PRT
<213> Homo sapiens

<400> 7099
Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His
        115                 120                 125             
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr
305                 310                 315                 320 
Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly
                325                 330                 335     
Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val
            340                 345                 350         
Lys Glu Pro Gln Thr Thr Val Ile His Asn Pro Val Asp Gly Ile Lys
        355                 360                 365             
Glu Ser Ser Asp Ser Ala Asn Thr Thr Ile Glu Asp Glu Asp Ala Lys
    370                 375                 380                 
Ala Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln Leu Ile Glu Ala
385                 390                 395                 400 
Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Phe Tyr Phe Glu Asn Leu
                405                 410                 415     
Leu Ala Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His
            420                 425                 430         
Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu
        435                 440                 445             
Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu
    450                 455                 460                 
Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His
465                 470                 475                 480 
Phe His Cys Ser Gly Ala Pro Val Ala Pro Leu Gln
                485                 490         


<210> 7100
<211> 377
<212> PRT
<213> Homo sapiens

<400> 7100
Met Asp Gly Thr Glu Ile Ala Val Ser Pro Arg Ser Leu His Ser Glu
 1               5                  10                  15      
Leu Met Cys Pro Ile Cys Leu Asp Met Leu Lys Asn Thr Met Thr Thr
            20                  25                  30          
Lys Glu Cys Leu His Arg Phe Cys Ser Asp Cys Ile Val Thr Ala Leu
        35                  40                  45              
Arg Ser Gly Asn Lys Glu Cys Pro Thr Cys Arg Lys Lys Leu Val Ser
    50                  55                  60                  
Lys Arg Ser Leu Arg Pro Asp Pro Asn Phe Asp Ala Leu Ile Ser Lys
65                  70                  75                  80  
Ile Tyr Pro Ser Arg Glu Glu Tyr Glu Ala His Gln Asp Arg Val Leu
                85                  90                  95      
Ile Arg Leu Ser Arg Leu His Asn Gln Gln Ala Leu Ser Ser Ser Ile
            100                 105                 110         
Glu Glu Gly Leu Arg Met Gln Ala Met His Arg Ala Gln Arg Val Arg
        115                 120                 125             
Arg Pro Ile Pro Gly Ser Asp Gln Thr Thr Thr Met Ser Gly Gly Glu
    130                 135                 140                 
Gly Glu Pro Gly Glu Gly Glu Gly Asp Gly Glu Asp Val Ser Ser Asp
145                 150                 155                 160 
Ser Ala Pro Asp Ser Ala Pro Gly Pro Ala Pro Lys Arg Pro Arg Gly
                165                 170                 175     
Gly Gly Ala Gly Gly Ser Ser Val Gly Thr Gly Gly Gly Gly Thr Gly
            180                 185                 190         
Gly Val Gly Gly Gly Ala Gly Ser Glu Asp Ser Gly Asp Arg Gly Gly
        195                 200                 205             
Thr Leu Gly Gly Gly Thr Leu Gly Pro Pro Ser Pro Pro Gly Ala Pro
    210                 215                 220                 
Ser Pro Pro Glu Pro Gly Gly Glu Ile Glu Leu Val Phe Arg Pro His
225                 230                 235                 240 
Pro Leu Leu Val Glu Lys Gly Glu Tyr Cys Gln Thr Arg Tyr Val Lys
                245                 250                 255     
Thr Thr Gly Asn Ala Thr Val Asp His Leu Ser Lys Tyr Leu Ala Leu
            260                 265                 270         
Arg Ile Ala Leu Glu Arg Arg Gln Gln Gln Glu Ala Gly Glu Pro Gly
        275                 280                 285             
Gly Pro Gly Gly Gly Ala Ser Asp Thr Gly Gly Pro Asp Gly Cys Gly
    290                 295                 300                 
Gly Glu Gly Gly Gly Ala Gly Gly Gly Asp Gly Pro Glu Glu Pro Ala
305                 310                 315                 320 
Leu Pro Ser Leu Glu Gly Val Ser Glu Lys Gln Tyr Thr Ile Tyr Ile
                325                 330                 335     
Ala Pro Gly Gly Gly Ala Phe Thr Thr Leu Asn Gly Ser Leu Thr Leu
            340                 345                 350         
Glu Leu Val Asn Glu Lys Phe Trp Lys Val Ser Arg Pro Leu Glu Leu
        355                 360                 365             
Cys Tyr Ala Pro Thr Lys Asp Pro Lys
    370                 375         


<210> 7101
<211> 963
<212> PRT
<213> Homo sapiens

<400> 7101
Met Ala Glu Gly Gly Gly Cys Arg Glu Arg Pro Asp Ala Glu Thr Gln
 1               5                  10                  15      
Lys Ser Glu Leu Gly Pro Leu Met Arg Thr Thr Leu Gln Arg Gly Ala
            20                  25                  30          
Gln Trp Tyr Leu Ile Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr
        35                  40                  45              
Val Gly Phe Asp Ser Trp Asp Met Tyr Asn Val Gly Glu His Asn Leu
    50                  55                  60                  
Phe Pro Gly Pro Ile Asp Asn Ser Gly Leu Phe Ser Asp Pro Glu Ser
65                  70                  75                  80  
Gln Thr Leu Lys Glu His Leu Ile Asp Glu Leu Asp Tyr Val Leu Val
                85                  90                  95      
Pro Thr Glu Ala Trp Asn Lys Leu Leu Asn Trp Tyr Gly Cys Val Glu
            100                 105                 110         
Gly Gln Gln Pro Ile Val Arg Lys Val Val Glu His Gly Leu Phe Val
        115                 120                 125             
Lys His Cys Lys Val Glu Val Tyr Leu Leu Glu Leu Lys Leu Cys Glu
    130                 135                 140                 
Asn Ser Asp Pro Thr Asn Val Leu Ser Cys His Phe Ser Lys Ala Asp
145                 150                 155                 160 
Thr Ile Ala Thr Ile Glu Lys Glu Met Arg Lys Leu Phe Asn Ile Pro
                165                 170                 175     
Ala Glu Arg Glu Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Tyr
            180                 185                 190         
Glu Gln Leu Ser Lys Leu Asp Asn Thr Val Gln Asp Ala Gly Leu Tyr
        195                 200                 205             
Gln Gly Gln Val Leu Val Ile Glu Pro Gln Asn Glu Asp Gly Thr Trp
    210                 215                 220                 
Pro Arg Gln Thr Leu Gln Ser Lys Ser Ser Thr Ala Pro Ser Arg Asn
225                 230                 235                 240 
Phe Thr Thr Ser Pro Lys Ser Ser Ala Ser Pro Tyr Ser Ser Val Ser
                245                 250                 255     
Ala Ser Leu Ile Ala Asn Gly Asp Ser Thr Ser Thr Cys Gly Met His
            260                 265                 270         
Ser Ser Gly Val Ser Arg Gly Gly Ser Gly Phe Ser Ala Ser Tyr Asn
        275                 280                 285             
Cys Gln Glu Pro Pro Ser Ser His Ile Gln Pro Gly Leu Cys Gly Leu
    290                 295                 300                 
Gly Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Leu Gln Cys Leu
305                 310                 315                 320 
Ser Asn Thr Ala Pro Leu Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu
                325                 330                 335     
Ala Glu Ile Asn Arg Asp Asn Pro Leu Gly Met Lys Gly Glu Ile Ala
            340                 345                 350         
Glu Ala Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly Arg Asp Ala
        355                 360                 365             
His Val Ala Pro Ser Met Phe Lys Thr Gln Val Gly Arg Phe Ala Pro
    370                 375                 380                 
Gln Phe Ser Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe
385                 390                 395                 400 
Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val Lys Lys Lys Pro
                405                 410                 415     
Tyr Leu Glu Leu Lys Asp Ala Asn Gly Arg Pro Asp Ala Val Val Ala
            420                 425                 430         
Lys Glu Ala Trp Glu Asn His Arg Leu Arg Asn Asp Ser Val Ile Val
        435                 440                 445             
Asp Thr Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys Pro Glu Cys
    450                 455                 460                 
Ala Lys Val Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro
465                 470                 475                 480 
Leu Pro Leu Lys Lys Asp Arg Val Met Glu Val Phe Leu Val Pro Ala
                485                 490                 495     
Asp Pro His Cys Arg Pro Thr Gln Tyr Arg Val Thr Val Pro Leu Met
            500                 505                 510         
Gly Ala Val Ser Asp Leu Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile
        515                 520                 525             
Ala Ala Glu Asn Met Val Val Ala Asp Val Tyr Asn His Arg Phe His
    530                 535                 540                 
Lys Ile Phe Gln Met Asp Glu Gly Leu Asn His Ile Met Pro Arg Asp
545                 550                 555                 560 
Asp Ile Phe Val Tyr Glu Val Cys Ser Thr Ser Val Asp Gly Ser Glu
                565                 570                 575     
Cys Val Thr Leu Pro Val Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser
            580                 585                 590         
Ser Thr Ser Ser Ala Ser Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser
        595                 600                 605             
Val Pro Lys His Lys Leu Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys
    610                 615                 620                 
Asp Arg Ile Ser Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe Gly
625                 630                 635                 640 
Ser Ser Pro Leu Glu Pro Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys
                645                 650                 655     
Glu Gly Glu Asp Glu Glu Glu Met Glu His Gln Glu Glu Gly Lys Glu
            660                 665                 670         
Gln Leu Ser Glu Thr Glu Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp
        675                 680                 685             
Pro Ser Glu Thr Thr Gln Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys
    690                 695                 700                 
Arg Leu Phe Thr Phe Ser Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile
705                 710                 715                 720 
Asn Ser Leu Ala Ala Asp Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser
                725                 730                 735     
Thr Leu Ala Met Asp Trp Asp Arg Glu Thr Arg Arg Leu Tyr Tyr Asp
            740                 745                 750         
Glu Gln Glu Ser Glu Ala Tyr Glu Lys His Val Ser Met Leu Gln Pro
        755                 760                 765             
Gln Lys Lys Lys Lys Thr Thr Val Ala Leu Arg Asp Cys Ile Glu Leu
    770                 775                 780                 
Phe Thr Thr Met Glu Thr Leu Gly Glu His Asp Pro Trp Tyr Cys Pro
785                 790                 795                 800 
Asn Cys Lys Lys His Gln Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser
                805                 810                 815     
Leu Pro Lys Ile Leu Val Val His Leu Lys Arg Phe Ser Tyr Asn Arg
            820                 825                 830         
Tyr Trp Arg Asp Lys Leu Asp Thr Val Val Glu Phe Pro Ile Arg Gly
        835                 840                 845             
Leu Asn Met Ser Glu Phe Val Cys Asn Leu Ser Ala Arg Pro Tyr Val
    850                 855                 860                 
Tyr Asp Leu Ile Ala Val Ser Asn His Tyr Gly Ala Met Gly Val Gly
865                 870                 875                 880 
His Tyr Thr Ala Tyr Ala Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr
                885                 890                 895     
Phe Asp Asp Ser Asn Val Ser Leu Ala Ser Glu Asp Gln Ile Val Thr
            900                 905                 910         
Lys Ala Ala Tyr Val Leu Phe Tyr Gln Arg Arg Asp Asp Glu Phe Tyr
        915                 920                 925             
Lys Thr Pro Ser Leu Ser Ser Ser Gly Ser Ser Asp Gly Gly Thr Arg
    930                 935                 940                 
Pro Ser Ser Ser Gln Gln Gly Phe Gly Asp Asp Glu Ala Cys Ser Met
945                 950                 955                 960 
Asp Thr Asn
            


<210> 7102
<211> 916
<212> PRT
<213> Homo sapiens

<400> 7102
Met Ala Glu Gly Gly Gly Cys Arg Glu Arg Pro Asp Ala Glu Thr Gln
 1               5                  10                  15      
Lys Ser Glu Leu Gly Pro Leu Met Arg Thr Thr Leu Gln Arg Gly Ala
            20                  25                  30          
Gln Trp Tyr Leu Ile Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr
        35                  40                  45              
Val Gly Phe Asp Ser Trp Asp Met Tyr Asn Val Gly Glu His Asn Leu
    50                  55                  60                  
Phe Pro Gly Pro Ile Asp Asn Ser Gly Leu Phe Ser Asp Pro Glu Ser
65                  70                  75                  80  
Gln Thr Leu Lys Glu His Leu Ile Asp Glu Leu Asp Tyr Val Leu Val
                85                  90                  95      
Pro Thr Glu Ala Trp Asn Lys Leu Leu Asn Trp Tyr Gly Cys Val Glu
            100                 105                 110         
Gly Gln Gln Pro Ile Val Arg Lys Val Val Glu His Gly Leu Phe Val
        115                 120                 125             
Lys His Cys Lys Val Glu Val Tyr Leu Leu Glu Leu Lys Leu Cys Glu
    130                 135                 140                 
Asn Ser Asp Pro Thr Asn Val Leu Ser Cys His Phe Ser Lys Ala Asp
145                 150                 155                 160 
Thr Ile Ala Thr Ile Glu Lys Glu Met Arg Lys Leu Phe Asn Ile Pro
                165                 170                 175     
Ala Glu Arg Glu Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Tyr
            180                 185                 190         
Glu Gln Leu Ser Lys Leu Asp Asn Thr Val Gln Asp Ala Gly Leu Tyr
        195                 200                 205             
Gln Gly Gln Val Leu Val Ile Glu Pro Gln Asn Glu Asp Gly Thr Trp
    210                 215                 220                 
Pro Arg Gln Thr Leu Gln Ser Asn Gly Ser Gly Phe Ser Ala Ser Tyr
225                 230                 235                 240 
Asn Cys Gln Glu Pro Pro Ser Ser His Ile Gln Pro Gly Leu Cys Gly
                245                 250                 255     
Leu Gly Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Leu Gln Cys
            260                 265                 270         
Leu Ser Asn Thr Ala Pro Leu Thr Asp Tyr Phe Leu Lys Asp Glu Tyr
        275                 280                 285             
Glu Ala Glu Ile Asn Arg Asp Asn Pro Leu Gly Met Lys Gly Glu Ile
    290                 295                 300                 
Ala Glu Ala Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly Arg Asp
305                 310                 315                 320 
Ala His Val Ala Pro Ser Met Phe Lys Thr Gln Val Gly Arg Phe Ala
                325                 330                 335     
Pro Gln Phe Ser Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala
            340                 345                 350         
Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val Lys Lys Lys
        355                 360                 365             
Pro Tyr Leu Glu Leu Lys Asp Ala Asn Gly Arg Pro Asp Ala Val Val
    370                 375                 380                 
Ala Lys Glu Ala Trp Glu Asn His Arg Leu Arg Asn Asp Ser Val Ile
385                 390                 395                 400 
Val Asp Thr Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys Pro Glu
                405                 410                 415     
Cys Ala Lys Val Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu Thr Leu
            420                 425                 430         
Pro Leu Pro Leu Lys Lys Asp Arg Val Met Glu Val Phe Leu Val Pro
        435                 440                 445             
Ala Asp Pro His Cys Arg Pro Thr Gln Tyr Arg Val Thr Val Pro Leu
    450                 455                 460                 
Met Gly Ala Val Ser Asp Leu Cys Glu Ala Leu Ser Arg Leu Ser Gly
465                 470                 475                 480 
Ile Ala Ala Glu Asn Met Val Val Ala Asp Val Tyr Asn His Arg Phe
                485                 490                 495     
His Lys Ile Phe Gln Met Asp Glu Gly Leu Asn His Ile Met Pro Arg
            500                 505                 510         
Asp Asp Ile Phe Val Tyr Glu Val Cys Ser Thr Ser Val Asp Gly Ser
        515                 520                 525             
Glu Cys Val Thr Leu Pro Val Tyr Phe Arg Glu Arg Lys Ser Arg Pro
    530                 535                 540                 
Ser Ser Thr Ser Ser Ala Ser Ala Leu Tyr Gly Gln Pro Leu Leu Leu
545                 550                 555                 560 
Ser Val Pro Lys His Lys Leu Thr Leu Glu Ser Leu Tyr Gln Ala Val
                565                 570                 575     
Cys Asp Arg Ile Ser Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe
            580                 585                 590         
Gly Ser Ser Pro Leu Glu Pro Gly Ala Cys Asn Gly Ser Arg Asn Ser
        595                 600                 605             
Cys Glu Gly Glu Asp Glu Glu Glu Met Glu His Gln Glu Glu Gly Lys
    610                 615                 620                 
Glu Gln Leu Ser Glu Thr Glu Gly Ser Gly Glu Asp Glu Pro Gly Asn
625                 630                 635                 640 
Asp Pro Ser Glu Thr Thr Gln Lys Lys Ile Lys Gly Gln Pro Cys Pro
                645                 650                 655     
Lys Arg Leu Phe Thr Phe Ser Leu Val Asn Ser Tyr Gly Thr Ala Asp
            660                 665                 670         
Ile Asn Ser Leu Ala Ala Asp Gly Lys Leu Leu Lys Leu Asn Ser Arg
        675                 680                 685             
Ser Thr Leu Ala Met Asp Trp Asp Arg Glu Thr Arg Arg Leu Tyr Tyr
    690                 695                 700                 
Asp Glu Gln Glu Ser Glu Ala Tyr Glu Lys His Val Ser Met Leu Gln
705                 710                 715                 720 
Pro Gln Lys Lys Lys Lys Thr Thr Val Ala Leu Arg Asp Cys Ile Glu
                725                 730                 735     
Leu Phe Thr Thr Met Glu Thr Leu Gly Glu His Asp Pro Trp Tyr Cys
            740                 745                 750         
Pro Asn Cys Lys Lys His Gln Gln Ala Thr Lys Lys Phe Asp Leu Trp
        755                 760                 765             
Ser Leu Pro Lys Ile Leu Val Val His Leu Lys Arg Phe Ser Tyr Asn
    770                 775                 780                 
Arg Tyr Trp Arg Asp Lys Leu Asp Thr Val Val Glu Phe Pro Ile Arg
785                 790                 795                 800 
Gly Leu Asn Met Ser Glu Phe Val Cys Asn Leu Ser Ala Arg Pro Tyr
                805                 810                 815     
Val Tyr Asp Leu Ile Ala Val Ser Asn His Tyr Gly Ala Met Gly Val
            820                 825                 830         
Gly His Tyr Thr Ala Tyr Ala Lys Asn Lys Leu Asn Gly Lys Trp Tyr
        835                 840                 845             
Tyr Phe Asp Asp Ser Asn Val Ser Leu Ala Ser Glu Asp Gln Ile Val
    850                 855                 860                 
Thr Lys Ala Ala Tyr Val Leu Phe Tyr Gln Arg Arg Asp Asp Glu Phe
865                 870                 875                 880 
Tyr Lys Thr Pro Ser Leu Ser Ser Ser Gly Ser Ser Asp Gly Gly Thr
                885                 890                 895     
Arg Pro Ser Ser Ser Gln Gln Gly Phe Gly Asp Asp Glu Ala Cys Ser
            900                 905                 910         
Met Asp Thr Asn
        915     


<210> 7103
<211> 604
<212> PRT
<213> Homo sapiens

<400> 7103
Met Asn Ile Val Glu Asn Ser Ile Phe Leu Ser Asn Leu Met Lys Ser
 1               5                  10                  15      
Ala Asn Thr Phe Glu Leu Lys Tyr Asp Leu Ser Cys Glu Leu Tyr Arg
            20                  25                  30          
Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg
        35                  40                  45              
Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val
    50                  55                  60                  
Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Arg Gly Asp
65                  70                  75                  80  
Ser Pro Thr Glu Lys His Lys Lys Leu Tyr Pro Ser Cys Arg Phe Val
                85                  90                  95      
Gln Ser Leu Asn Ser Val Asn Asn Leu Glu Ala Thr Ser Gln Pro Thr
            100                 105                 110         
Phe Pro Ser Ser Val Thr Asn Ser Thr His Ser Leu Leu Pro Gly Thr
        115                 120                 125             
Glu Asn Ser Gly Tyr Phe Arg Gly Ser Tyr Ser Asn Ser Pro Ser Asn
    130                 135                 140                 
Pro Val Asn Ser Arg Ala Asn Gln Asp Phe Ser Ala Leu Met Arg Ser
145                 150                 155                 160 
Ser Tyr His Cys Ala Met Asn Asn Glu Asn Ala Arg Leu Leu Thr Phe
                165                 170                 175     
Gln Thr Trp Pro Leu Thr Phe Leu Ser Pro Thr Asp Leu Ala Lys Ala
            180                 185                 190         
Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys
        195                 200                 205             
Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asn Ala Met Ser Glu
    210                 215                 220                 
His Leu Arg His Phe Pro Lys Cys Pro Phe Ile Glu Asn Gln Leu Gln
225                 230                 235                 240 
Asp Thr Ser Arg Tyr Thr Val Ser Asn Leu Ser Met Gln Thr His Ala
                245                 250                 255     
Ala Arg Phe Lys Thr Phe Phe Asn Trp Pro Ser Ser Val Leu Val Asn
            260                 265                 270         
Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Asn Ser Asp
        275                 280                 285             
Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser
    290                 295                 300                 
Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro Arg Cys Glu
305                 310                 315                 320 
Tyr Leu Ile Arg Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala
                325                 330                 335     
Ser Tyr Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Ser Pro
            340                 345                 350         
Gly Asp Glu Asn Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu
        355                 360                 365             
Asp His Ser Glu Asp Ala Ile Met Met Asn Thr Pro Val Ile Asn Ala
    370                 375                 380                 
Ala Val Glu Met Gly Phe Ser Arg Ser Leu Val Lys Gln Thr Val Gln
385                 390                 395                 400 
Arg Lys Ile Leu Ala Thr Gly Glu Asn Tyr Arg Leu Val Asn Asp Leu
                405                 410                 415     
Val Leu Asp Leu Leu Asn Ala Glu Asp Glu Ile Arg Glu Glu Glu Arg
            420                 425                 430         
Glu Arg Ala Thr Glu Glu Lys Glu Ser Asn Asp Leu Leu Leu Ile Arg
        435                 440                 445             
Lys Asn Arg Met Ala Leu Phe Gln His Leu Thr Cys Val Ile Pro Ile
    450                 455                 460                 
Leu Asp Ser Leu Leu Thr Ala Gly Ile Ile Asn Glu Gln Glu His Asp
465                 470                 475                 480 
Val Ile Lys Gln Lys Thr Gln Thr Ser Leu Gln Ala Arg Glu Leu Ile
                485                 490                 495     
Asp Thr Ile Leu Val Lys Gly Asn Ile Ala Ala Thr Val Phe Arg Asn
            500                 505                 510         
Ser Leu Gln Glu Ala Glu Ala Val Leu Tyr Glu His Leu Phe Val Gln
        515                 520                 525             
Gln Asp Ile Lys Tyr Ile Pro Thr Glu Asp Val Ser Asp Leu Pro Val
    530                 535                 540                 
Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys
545                 550                 555                 560 
Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys Gly His Leu Val
                565                 570                 575     
Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg
            580                 585                 590         
Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu Ser
        595                 600                 


<210> 7104
<211> 990
<212> PRT
<213> Homo sapiens

<400> 7104
Met Ser Glu Glu Thr Arg Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys
 1               5                  10                  15      
Leu Arg Glu Tyr Gln Gln Arg Asn Ser Pro Gly Val Pro Thr Gly Ala
            20                  25                  30          
Lys Lys Lys Lys Lys Ile Lys Asn Gly Ser Asn Pro Glu Thr Thr Thr
        35                  40                  45              
Ser Gly Gly Cys His Ser Pro Glu Asp Thr Pro Lys Asp Asn Ala Ala
    50                  55                  60                  
Thr Leu Gln Pro Ser Asp Asp Thr Val Leu Pro Gly Gly Val Pro Ser
65                  70                  75                  80  
Pro Gly Ala Ser Leu Thr Ser Met Ala Ala Ser Gln Asn His Asp Ala
                85                  90                  95      
Asp Asn Val Pro Asn Leu Met Asp Glu Thr Lys Thr Phe Ser Ser Thr
            100                 105                 110         
Glu Ser Leu Arg Gln Leu Ser Gln Gln Leu Asn Gly Leu Val Cys Glu
        115                 120                 125             
Ser Ala Thr Cys Val Asn Gly Glu Gly Pro Ala Ser Ser Ala Asn Leu
    130                 135                 140                 
Lys Asp Leu Glu Ser Arg Tyr Gln Gln Leu Ala Val Ala Leu Asp Ser
145                 150                 155                 160 
Ser Tyr Val Thr Asn Lys Gln Leu Asn Ile Thr Ile Glu Lys Leu Lys
                165                 170                 175     
Gln Gln Asn Gln Glu Ile Thr Asp Gln Leu Glu Glu Glu Lys Lys Glu
            180                 185                 190         
Cys His Gln Lys Gln Gly Ala Leu Arg Glu Gln Leu Gln Val His Ile
        195                 200                 205             
Gln Thr Ile Gly Ile Leu Val Ser Glu Lys Ala Glu Leu Gln Thr Ala
    210                 215                 220                 
Leu Ala His Thr Gln His Ala Ala Arg Gln Lys Glu Gly Glu Ser Glu
225                 230                 235                 240 
Asp Leu Ala Ser Arg Leu Gln Tyr Ser Arg Arg Arg Val Gly Glu Leu
                245                 250                 255     
Glu Arg Ala Leu Ser Ala Val Ser Thr Gln Gln Lys Lys Ala Asp Arg
            260                 265                 270         
Tyr Asn Lys Glu Leu Thr Lys Glu Arg Asp Ala Leu Arg Leu Glu Leu
        275                 280                 285             
Tyr Lys Asn Thr Gln Ser Asn Glu Asp Leu Lys Gln Glu Lys Ser Glu
    290                 295                 300                 
Leu Glu Glu Lys Leu Arg Val Leu Val Thr Glu Lys Ala Gly Met Gln
305                 310                 315                 320 
Leu Asn Leu Glu Glu Leu Gln Lys Lys Leu Glu Met Thr Glu Leu Leu
                325                 330                 335     
Leu Gln Gln Phe Ser Ser Arg Cys Glu Ala Pro Asp Ala Asn Gln Gln
            340                 345                 350         
Leu Gln Gln Ala Met Glu Glu Arg Ala Gln Leu Glu Ala His Leu Gly
        355                 360                 365             
Gln Val Met Glu Ser Val Arg Gln Leu Gln Met Glu Arg Asp Lys Tyr
    370                 375                 380                 
Ala Glu Asn Leu Lys Gly Glu Ser Ala Met Trp Arg Gln Arg Met Gln
385                 390                 395                 400 
Gln Met Ser Glu Gln Val His Thr Leu Arg Glu Glu Lys Glu Cys Ser
                405                 410                 415     
Met Ser Arg Val Gln Glu Leu Glu Thr Ser Leu Ala Glu Leu Arg Asn
            420                 425                 430         
Gln Met Ala Glu Pro Pro Pro Pro Glu Pro Pro Ala Gly Pro Ser Glu
        435                 440                 445             
Val Glu Gln Gln Leu Gln Ala Glu Ala Glu His Leu Arg Lys Glu Leu
    450                 455                 460                 
Glu Gly Leu Ala Gly Gln Leu Gln Ala Gln Val Gln Asp Asn Glu Gly
465                 470                 475                 480 
Leu Ser Arg Leu Asn Arg Glu Gln Glu Glu Arg Leu Leu Glu Leu Glu
                485                 490                 495     
Arg Ala Ala Glu Leu Trp Gly Glu Gln Ala Glu Ala Arg Arg Gln Ile
            500                 505                 510         
Leu Glu Thr Met Gln Asn Asp Arg Thr Thr Ile Ser Arg Ala Leu Ser
        515                 520                 525             
Gln Asn Arg Glu Leu Lys Glu Gln Leu Ala Glu Leu Gln Ser Gly Phe
    530                 535                 540                 
Val Lys Leu Thr Asn Glu Asn Met Glu Ile Thr Ser Ala Leu Gln Ser
545                 550                 555                 560 
Glu Gln His Val Lys Arg Glu Leu Gly Lys Lys Leu Gly Glu Leu Gln
                565                 570                 575     
Glu Lys Leu Ser Glu Leu Lys Glu Thr Val Glu Leu Lys Ser Gln Glu
            580                 585                 590         
Ala Gln Ser Leu Gln Gln Gln Arg Asp Gln Tyr Leu Gly His Leu Gln
        595                 600                 605             
Gln Tyr Val Ala Ala Tyr Gln Gln Leu Thr Ser Glu Lys Glu Val Leu
    610                 615                 620                 
His Asn Gln Leu Leu Leu Gln Thr Gln Leu Val Asp Gln Leu Gln Gln
625                 630                 635                 640 
Gln Glu Ala Gln Gly Lys Ala Val Ala Glu Met Ala Arg Gln Glu Leu
                645                 650                 655     
Gln Glu Thr Gln Glu Arg Leu Glu Ala Ala Thr Gln Gln Asn Gln Gln
            660                 665                 670         
Leu Arg Ala Gln Leu Ser Leu Met Ala His Pro Gly Glu Gly Asp Gly
        675                 680                 685             
Leu Asp Arg Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Ala
    690                 695                 700                 
Val Ala Val Pro Gln Pro Met Pro Ser Ile Pro Glu Asp Leu Glu Ser
705                 710                 715                 720 
Arg Glu Ala Met Val Ala Phe Phe Asn Ser Ala Val Ala Ser Ala Glu
                725                 730                 735     
Glu Glu Gln Ala Arg Leu Arg Gly Gln Leu Lys Glu Gln Arg Val Arg
            740                 745                 750         
Cys Arg Arg Leu Ala His Leu Leu Ala Ser Ala Gln Lys Glu Pro Glu
        755                 760                 765             
Ala Ala Ala Pro Ala Pro Gly Thr Gly Gly Asp Ser Val Cys Gly Glu
    770                 775                 780                 
Thr His Arg Ala Leu Gln Gly Ala Met Glu Lys Leu Gln Ser Arg Phe
785                 790                 795                 800 
Met Glu Leu Met Gln Glu Lys Ala Asp Leu Lys Glu Arg Val Glu Glu
                805                 810                 815     
Leu Glu His Arg Cys Ile Gln Leu Ser Gly Glu Thr Asp Thr Ile Gly
            820                 825                 830         
Glu Tyr Ile Ala Leu Tyr Gln Ser Gln Arg Ala Val Leu Lys Glu Arg
        835                 840                 845             
His Arg Glu Lys Glu Glu Tyr Ile Ser Arg Leu Ala Gln Asp Lys Glu
    850                 855                 860                 
Glu Met Lys Val Lys Leu Leu Glu Leu Gln Glu Leu Val Leu Arg Leu
865                 870                 875                 880 
Val Gly Asp Arg Asn Glu Trp His Gly Arg Phe Leu Ala Ala Ala Gln
                885                 890                 895     
Asn Pro Ala Asp Glu Pro Thr Ser Gly Ala Pro Ala Pro Gln Glu Leu
            900                 905                 910         
Gly Ala Ala Asn Gln Gln Gly Asp Leu Cys Glu Val Ser Leu Ala Gly
        915                 920                 925             
Ser Val Glu Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Pro Arg Asp
    930                 935                 940                 
Asn Pro Thr Ala Gln Gln Ile Met Gln Leu Leu Arg Glu Met Gln Asn
945                 950                 955                 960 
Pro Arg Glu Arg Pro Gly Leu Gly Ser Asn Pro Cys Ile Pro Phe Phe
                965                 970                 975     
Tyr Arg Ala Asp Glu Asn Asp Glu Val Lys Ile Thr Val Ile
            980                 985                 990 


<210> 7105
<211> 832
<212> PRT
<213> Homo sapiens

<400> 7105
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro
        515                 520                 525             
Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser
    530                 535                 540                 
Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile
545                 550                 555                 560 
Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala
                565                 570                 575     
Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly
            580                 585                 590         
Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile
        595                 600                 605             
Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser
    610                 615                 620                 
Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile
625                 630                 635                 640 
Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln
                645                 650                 655     
Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu
            660                 665                 670         
Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys
        675                 680                 685             
Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser
    690                 695                 700                 
Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln
705                 710                 715                 720 
Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly
                725                 730                 735     
Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser
            740                 745                 750         
Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg
        755                 760                 765             
Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser
    770                 775                 780                 
Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn Asn Tyr Ser Thr Pro
785                 790                 795                 800 
Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu
                805                 810                 815     
Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Lys Ile
            820                 825                 830         


<210> 7106
<211> 962
<212> PRT
<213> Homo sapiens

<400> 7106
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
625                 630                 635                 640 
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
                645                 650                 655     
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
            660                 665                 670         
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
        675                 680                 685             
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
    690                 695                 700                 
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
705                 710                 715                 720 
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
                725                 730                 735     
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
            740                 745                 750         
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
        755                 760                 765             
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
    770                 775                 780                 
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
785                 790                 795                 800 
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
                805                 810                 815     
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
            820                 825                 830         
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
        835                 840                 845             
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
    850                 855                 860                 
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu
865                 870                 875                 880 
Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn
                885                 890                 895     
Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp
            900                 905                 910         
Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro
        915                 920                 925             
Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val
    930                 935                 940                 
Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln
945                 950                 955                 960 
Lys Ile
        


<210> 7107
<211> 859
<212> PRT
<213> Homo sapiens

<400> 7107
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro Ile
                565                 570                 575     
Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro
            580                 585                 590         
Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr
        595                 600                 605             
Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser
    610                 615                 620                 
Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg
625                 630                 635                 640 
Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala
                645                 650                 655     
Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly
            660                 665                 670         
Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly
        675                 680                 685             
Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln
    690                 695                 700                 
Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn
705                 710                 715                 720 
Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu
                725                 730                 735     
Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly
            740                 745                 750         
Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr
        755                 760                 765             
Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp
    770                 775                 780                 
Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln
785                 790                 795                 800 
Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn
                805                 810                 815     
Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp
            820                 825                 830         
His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro
        835                 840                 845             
Leu Lys Gly Thr Thr Pro Leu Met Gln Lys Ile
    850                 855                 


<210> 7108
<211> 596
<212> PRT
<213> Homo sapiens

<400> 7108
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu
    290                 295                 300                 
Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr
305                 310                 315                 320 
Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu
                325                 330                 335     
Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser
            340                 345                 350         
Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu
        355                 360                 365             
Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg
    370                 375                 380                 
Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His
385                 390                 395                 400 
Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val
                405                 410                 415     
Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu
            420                 425                 430         
Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser
        435                 440                 445             
Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala
    450                 455                 460                 
Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu
465                 470                 475                 480 
Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val
                485                 490                 495     
Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu
            500                 505                 510         
Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val
        515                 520                 525             
Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp
    530                 535                 540                 
Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn
545                 550                 555                 560 
Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg
                565                 570                 575     
Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu
            580                 585                 590         
Met Gln Lys Ile
        595     


<210> 7109
<211> 948
<212> PRT
<213> Homo sapiens

<400> 7109
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala
625                 630                 635                 640 
Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr
                645                 650                 655     
Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu
            660                 665                 670         
Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile
        675                 680                 685             
Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser
    690                 695                 700                 
Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr
705                 710                 715                 720 
Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn
                725                 730                 735     
Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile
            740                 745                 750         
Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp
        755                 760                 765             
Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu
    770                 775                 780                 
Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln
785                 790                 795                 800 
Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu
                805                 810                 815     
Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr
            820                 825                 830         
Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp
        835                 840                 845             
Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser
    850                 855                 860                 
Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp
865                 870                 875                 880 
Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr
                885                 890                 895     
Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr
            900                 905                 910         
Thr Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu
        915                 920                 925             
Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser
    930                 935                 940                 
Met Gln Lys Ile
945             


<210> 7110
<211> 885
<212> PRT
<213> Homo sapiens

<400> 7110
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe Ser
                565                 570                 575     
Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
            580                 585                 590         
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
        595                 600                 605             
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
    610                 615                 620                 
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
625                 630                 635                 640 
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
                645                 650                 655     
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
            660                 665                 670         
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
        675                 680                 685             
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
    690                 695                 700                 
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
705                 710                 715                 720 
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
                725                 730                 735     
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
            740                 745                 750         
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
        755                 760                 765             
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
    770                 775                 780                 
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
785                 790                 795                 800 
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
                805                 810                 815     
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu
            820                 825                 830         
Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn
        835                 840                 845             
Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp
    850                 855                 860                 
Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro
865                 870                 875                 880 
Leu Met Gln Lys Ile
                885 


<210> 7111
<211> 847
<212> PRT
<213> Homo sapiens

<400> 7111
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe
        515                 520                 525             
Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp
    530                 535                 540                 
Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln
545                 550                 555                 560 
Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr
                565                 570                 575     
Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala
            580                 585                 590         
Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu
        595                 600                 605             
Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg
    610                 615                 620                 
Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala
625                 630                 635                 640 
Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys
                645                 650                 655     
Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp
            660                 665                 670         
Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn
        675                 680                 685             
Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu
    690                 695                 700                 
Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala
705                 710                 715                 720 
Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys
                725                 730                 735     
Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu
            740                 745                 750         
Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr
        755                 760                 765             
Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser
    770                 775                 780                 
Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly
785                 790                 795                 800 
Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln
                805                 810                 815     
Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu
            820                 825                 830         
Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
        835                 840                 845         


<210> 7112
<211> 610
<212> PRT
<213> Homo sapiens

<400> 7112
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys
    290                 295                 300                 
Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg
305                 310                 315                 320 
Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val
                325                 330                 335     
Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu
            340                 345                 350         
Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr
        355                 360                 365             
Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser
    370                 375                 380                 
Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala
385                 390                 395                 400 
Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu
                405                 410                 415     
Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly
            420                 425                 430         
Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser
        435                 440                 445             
Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala
    450                 455                 460                 
Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn
465                 470                 475                 480 
Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val
                485                 490                 495     
Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys
            500                 505                 510         
Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser
        515                 520                 525             
Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile
    530                 535                 540                 
Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln
545                 550                 555                 560 
Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn Asn Tyr Ser
                565                 570                 575     
Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly
            580                 585                 590         
Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln
        595                 600                 605             
Lys Ile
    610 


<210> 7113
<211> 625
<212> PRT
<213> Homo sapiens

<400> 7113
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu
    290                 295                 300                 
Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr
305                 310                 315                 320 
Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu
                325                 330                 335     
Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser
            340                 345                 350         
Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu
        355                 360                 365             
Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg
    370                 375                 380                 
Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His
385                 390                 395                 400 
Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val
                405                 410                 415     
Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu
            420                 425                 430         
Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser
        435                 440                 445             
Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala
    450                 455                 460                 
Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu
465                 470                 475                 480 
Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val
                485                 490                 495     
Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu
            500                 505                 510         
Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val
        515                 520                 525             
Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp
    530                 535                 540                 
Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn
545                 550                 555                 560 
Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg
                565                 570                 575     
Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu
            580                 585                 590         
Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu
        595                 600                 605             
Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys
    610                 615                 620                 
Ile
625 


<210> 7114
<211> 879
<212> PRT
<213> Homo sapiens

<400> 7114
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro Ile
                565                 570                 575     
Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro
            580                 585                 590         
Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr
        595                 600                 605             
Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser
    610                 615                 620                 
Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg
625                 630                 635                 640 
Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala
                645                 650                 655     
Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly
            660                 665                 670         
Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly
        675                 680                 685             
Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln
    690                 695                 700                 
Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn
705                 710                 715                 720 
Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu
                725                 730                 735     
Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly
            740                 745                 750         
Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr
        755                 760                 765             
Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp
    770                 775                 780                 
Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln
785                 790                 795                 800 
Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn
                805                 810                 815     
Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn
            820                 825                 830         
Met Gly Ser Asn Thr Lys Ser Leu Asp Asn Asn Tyr Ser Thr Pro Asn
        835                 840                 845             
Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly
    850                 855                 860                 
Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Lys Ile
865                 870                 875                 


<210> 7115
<211> 812
<212> PRT
<213> Homo sapiens

<400> 7115
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro
        515                 520                 525             
Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser
    530                 535                 540                 
Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile
545                 550                 555                 560 
Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala
                565                 570                 575     
Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly
            580                 585                 590         
Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile
        595                 600                 605             
Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser
    610                 615                 620                 
Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile
625                 630                 635                 640 
Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln
                645                 650                 655     
Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu
            660                 665                 670         
Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys
        675                 680                 685             
Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser
    690                 695                 700                 
Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln
705                 710                 715                 720 
Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly
                725                 730                 735     
Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser
            740                 745                 750         
Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg
        755                 760                 765             
Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly
    770                 775                 780                 
Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu
785                 790                 795                 800 
Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Lys Ile
                805                 810         


<210> 7116
<211> 841
<212> PRT
<213> Homo sapiens

<400> 7116
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro
        515                 520                 525             
Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser
    530                 535                 540                 
Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile
545                 550                 555                 560 
Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala
                565                 570                 575     
Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly
            580                 585                 590         
Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile
        595                 600                 605             
Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser
    610                 615                 620                 
Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile
625                 630                 635                 640 
Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln
                645                 650                 655     
Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu
            660                 665                 670         
Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys
        675                 680                 685             
Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser
    690                 695                 700                 
Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln
705                 710                 715                 720 
Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly
                725                 730                 735     
Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser
            740                 745                 750         
Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg
        755                 760                 765             
Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly
    770                 775                 780                 
Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu
785                 790                 795                 800 
Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu Gly Gln Glu Ser
                805                 810                 815     
Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln
            820                 825                 830         
Val Ser Tyr Pro Ser Met Gln Lys Ile
        835                 840     


<210> 7117
<211> 894
<212> PRT
<213> Homo sapiens

<400> 7117
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe Ser
                565                 570                 575     
Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
            580                 585                 590         
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
        595                 600                 605             
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
    610                 615                 620                 
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
625                 630                 635                 640 
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
                645                 650                 655     
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
            660                 665                 670         
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
        675                 680                 685             
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
    690                 695                 700                 
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
705                 710                 715                 720 
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
                725                 730                 735     
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
            740                 745                 750         
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
        755                 760                 765             
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
    770                 775                 780                 
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
785                 790                 795                 800 
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
                805                 810                 815     
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr
            820                 825                 830         
Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp
        835                 840                 845             
Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Asp
    850                 855                 860                 
Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp
865                 870                 875                 880 
Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
                885                 890                 


<210> 7118
<211> 861
<212> PRT
<213> Homo sapiens

<400> 7118
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro
        515                 520                 525             
Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser
    530                 535                 540                 
Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile
545                 550                 555                 560 
Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala
                565                 570                 575     
Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly
            580                 585                 590         
Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile
        595                 600                 605             
Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser
    610                 615                 620                 
Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile
625                 630                 635                 640 
Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln
                645                 650                 655     
Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu
            660                 665                 670         
Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys
        675                 680                 685             
Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser
    690                 695                 700                 
Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln
705                 710                 715                 720 
Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly
                725                 730                 735     
Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser
            740                 745                 750         
Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg
        755                 760                 765             
Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser
    770                 775                 780                 
Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn Asn Tyr Ser Thr Pro
785                 790                 795                 800 
Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu
                805                 810                 815     
Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu
            820                 825                 830         
Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp
        835                 840                 845             
Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
    850                 855                 860     


<210> 7119
<211> 639
<212> PRT
<213> Homo sapiens

<400> 7119
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys
    290                 295                 300                 
Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg
305                 310                 315                 320 
Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val
                325                 330                 335     
Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu
            340                 345                 350         
Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr
        355                 360                 365             
Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser
    370                 375                 380                 
Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala
385                 390                 395                 400 
Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu
                405                 410                 415     
Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly
            420                 425                 430         
Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser
        435                 440                 445             
Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala
    450                 455                 460                 
Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn
465                 470                 475                 480 
Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val
                485                 490                 495     
Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys
            500                 505                 510         
Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser
        515                 520                 525             
Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile
    530                 535                 540                 
Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln
545                 550                 555                 560 
Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn Asn Tyr Ser
                565                 570                 575     
Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly
            580                 585                 590         
Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln
        595                 600                 605             
Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu
    610                 615                 620                 
Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
625                 630                 635                 


<210> 7120
<211> 939
<212> PRT
<213> Homo sapiens

<400> 7120
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala
625                 630                 635                 640 
Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr
                645                 650                 655     
Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu
            660                 665                 670         
Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile
        675                 680                 685             
Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser
    690                 695                 700                 
Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr
705                 710                 715                 720 
Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn
                725                 730                 735     
Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile
            740                 745                 750         
Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp
        755                 760                 765             
Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu
    770                 775                 780                 
Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln
785                 790                 795                 800 
Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu
                805                 810                 815     
Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr
            820                 825                 830         
Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp
        835                 840                 845             
Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser
    850                 855                 860                 
Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp
865                 870                 875                 880 
Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn
                885                 890                 895     
Thr Lys Ser Leu Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp
            900                 905                 910         
His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro
        915                 920                 925             
Leu Lys Gly Thr Thr Pro Leu Met Gln Lys Ile
    930                 935                 


<210> 7121
<211> 867
<212> PRT
<213> Homo sapiens

<400> 7121
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe
        515                 520                 525             
Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp
    530                 535                 540                 
Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln
545                 550                 555                 560 
Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr
                565                 570                 575     
Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala
            580                 585                 590         
Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu
        595                 600                 605             
Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg
    610                 615                 620                 
Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala
625                 630                 635                 640 
Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys
                645                 650                 655     
Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp
            660                 665                 670         
Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn
        675                 680                 685             
Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu
    690                 695                 700                 
Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala
705                 710                 715                 720 
Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys
                725                 730                 735     
Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu
            740                 745                 750         
Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr
        755                 760                 765             
Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg
    770                 775                 780                 
Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp
785                 790                 795                 800 
Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu
                805                 810                 815     
Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr
            820                 825                 830         
Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp
        835                 840                 845             
Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met
    850                 855                 860                 
Gln Lys Ile
865         


<210> 7122
<211> 933
<212> PRT
<213> Homo sapiens

<400> 7122
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
625                 630                 635                 640 
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
                645                 650                 655     
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
            660                 665                 670         
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
        675                 680                 685             
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
    690                 695                 700                 
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
705                 710                 715                 720 
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
                725                 730                 735     
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
            740                 745                 750         
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
        755                 760                 765             
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
    770                 775                 780                 
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
785                 790                 795                 800 
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
                805                 810                 815     
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
            820                 825                 830         
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
        835                 840                 845             
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
    850                 855                 860                 
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu
865                 870                 875                 880 
Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn
                885                 890                 895     
Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp
            900                 905                 910         
Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro
        915                 920                 925             
Leu Met Gln Lys Ile
    930             


<210> 7123
<211> 616
<212> PRT
<213> Homo sapiens

<400> 7123
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu
    290                 295                 300                 
Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr
305                 310                 315                 320 
Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu
                325                 330                 335     
Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser
            340                 345                 350         
Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu
        355                 360                 365             
Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg
    370                 375                 380                 
Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His
385                 390                 395                 400 
Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val
                405                 410                 415     
Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu
            420                 425                 430         
Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser
        435                 440                 445             
Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala
    450                 455                 460                 
Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu
465                 470                 475                 480 
Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val
                485                 490                 495     
Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu
            500                 505                 510         
Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val
        515                 520                 525             
Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp
    530                 535                 540                 
Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro
545                 550                 555                 560 
Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser
                565                 570                 575     
Leu Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg
            580                 585                 590         
Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly
        595                 600                 605             
Thr Thr Pro Leu Met Gln Lys Ile
    610                 615     


<210> 7124
<211> 818
<212> PRT
<213> Homo sapiens

<400> 7124
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe
        515                 520                 525             
Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp
    530                 535                 540                 
Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln
545                 550                 555                 560 
Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr
                565                 570                 575     
Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala
            580                 585                 590         
Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu
        595                 600                 605             
Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg
    610                 615                 620                 
Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala
625                 630                 635                 640 
Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys
                645                 650                 655     
Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp
            660                 665                 670         
Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn
        675                 680                 685             
Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu
    690                 695                 700                 
Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala
705                 710                 715                 720 
Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys
                725                 730                 735     
Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu
            740                 745                 750         
Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr
        755                 760                 765             
Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser
    770                 775                 780                 
Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly
785                 790                 795                 800 
Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln
                805                 810                 815     
Lys Ile
        


<210> 7125
<211> 919
<212> PRT
<213> Homo sapiens

<400> 7125
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala
625                 630                 635                 640 
Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr
                645                 650                 655     
Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu
            660                 665                 670         
Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile
        675                 680                 685             
Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser
    690                 695                 700                 
Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr
705                 710                 715                 720 
Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn
                725                 730                 735     
Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile
            740                 745                 750         
Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp
        755                 760                 765             
Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu
    770                 775                 780                 
Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln
785                 790                 795                 800 
Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu
                805                 810                 815     
Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr
            820                 825                 830         
Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp
        835                 840                 845             
Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser
    850                 855                 860                 
Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp
865                 870                 875                 880 
Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr
                885                 890                 895     
Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr
            900                 905                 910         
Thr Pro Leu Met Gln Lys Ile
        915                 


<210> 7126
<211> 865
<212> PRT
<213> Homo sapiens

<400> 7126
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe Ser
                565                 570                 575     
Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
            580                 585                 590         
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
        595                 600                 605             
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
    610                 615                 620                 
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
625                 630                 635                 640 
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
                645                 650                 655     
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
            660                 665                 670         
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
        675                 680                 685             
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
    690                 695                 700                 
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
705                 710                 715                 720 
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
                725                 730                 735     
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
            740                 745                 750         
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
        755                 760                 765             
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
    770                 775                 780                 
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
785                 790                 795                 800 
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
                805                 810                 815     
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr
            820                 825                 830         
Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp
        835                 840                 845             
Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Lys
    850                 855                 860                 
Ile
865 


<210> 7127
<211> 908
<212> PRT
<213> Homo sapiens

<400> 7127
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro Ile
                565                 570                 575     
Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro
            580                 585                 590         
Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr
        595                 600                 605             
Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser
    610                 615                 620                 
Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg
625                 630                 635                 640 
Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala
                645                 650                 655     
Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly
            660                 665                 670         
Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly
        675                 680                 685             
Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln
    690                 695                 700                 
Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn
705                 710                 715                 720 
Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu
                725                 730                 735     
Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly
            740                 745                 750         
Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr
        755                 760                 765             
Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp
    770                 775                 780                 
Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln
785                 790                 795                 800 
Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn
                805                 810                 815     
Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn
            820                 825                 830         
Met Gly Ser Asn Thr Lys Ser Leu Asp Asn Asn Tyr Ser Thr Pro Asn
        835                 840                 845             
Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly
    850                 855                 860                 
Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu Gly
865                 870                 875                 880 
Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu
                885                 890                 895     
Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
            900                 905             


<210> 7128
<211> 590
<212> PRT
<213> Homo sapiens

<400> 7128
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys
    290                 295                 300                 
Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg
305                 310                 315                 320 
Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val
                325                 330                 335     
Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu
            340                 345                 350         
Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr
        355                 360                 365             
Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser
    370                 375                 380                 
Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala
385                 390                 395                 400 
Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu
                405                 410                 415     
Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly
            420                 425                 430         
Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser
        435                 440                 445             
Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala
    450                 455                 460                 
Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn
465                 470                 475                 480 
Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val
                485                 490                 495     
Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys
            500                 505                 510         
Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser
        515                 520                 525             
Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile
    530                 535                 540                 
Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr Pro Asn Glu
545                 550                 555                 560 
Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp
                565                 570                 575     
Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Lys Ile
            580                 585                 590 


<210> 7129
<211> 914
<212> PRT
<213> Homo sapiens

<400> 7129
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe Ser
                565                 570                 575     
Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
            580                 585                 590         
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
        595                 600                 605             
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
    610                 615                 620                 
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
625                 630                 635                 640 
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
                645                 650                 655     
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
            660                 665                 670         
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
        675                 680                 685             
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
    690                 695                 700                 
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
705                 710                 715                 720 
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
                725                 730                 735     
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
            740                 745                 750         
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
        755                 760                 765             
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
    770                 775                 780                 
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
785                 790                 795                 800 
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
                805                 810                 815     
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu
            820                 825                 830         
Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn
        835                 840                 845             
Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp
    850                 855                 860                 
Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro
865                 870                 875                 880 
Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val
                885                 890                 895     
Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln
            900                 905                 910         
Lys Ile
        


<210> 7130
<211> 645
<212> PRT
<213> Homo sapiens

<400> 7130
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu
    290                 295                 300                 
Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr
305                 310                 315                 320 
Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu
                325                 330                 335     
Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser
            340                 345                 350         
Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu
        355                 360                 365             
Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg
    370                 375                 380                 
Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His
385                 390                 395                 400 
Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val
                405                 410                 415     
Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu
            420                 425                 430         
Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser
        435                 440                 445             
Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala
    450                 455                 460                 
Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu
465                 470                 475                 480 
Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val
                485                 490                 495     
Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu
            500                 505                 510         
Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val
        515                 520                 525             
Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp
    530                 535                 540                 
Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro
545                 550                 555                 560 
Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser
                565                 570                 575     
Leu Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg
            580                 585                 590         
Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly
        595                 600                 605             
Thr Thr Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu Glu Glu Glu
    610                 615                 620                 
Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val Ser Tyr Pro
625                 630                 635                 640 
Ser Met Gln Lys Ile
                645 


<210> 7131
<211> 838
<212> PRT
<213> Homo sapiens

<400> 7131
Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro
 1               5                  10                  15      
Glu Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr
            20                  25                  30          
Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr
        35                  40                  45              
Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val
    50                  55                  60                  
Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp
65                  70                  75                  80  
Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala
                85                  90                  95      
Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr
            100                 105                 110         
Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly
        115                 120                 125             
Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met
    130                 135                 140                 
Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro
145                 150                 155                 160 
Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro
                165                 170                 175     
Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp
            180                 185                 190         
Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly
        195                 200                 205             
Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile
    210                 215                 220                 
Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln
225                 230                 235                 240 
His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly
                245                 250                 255     
Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala
            260                 265                 270         
Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr
        275                 280                 285             
Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg
    290                 295                 300                 
Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys
305                 310                 315                 320 
Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe
                325                 330                 335     
Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val
            340                 345                 350         
Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr
        355                 360                 365             
Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile
    370                 375                 380                 
Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val
385                 390                 395                 400 
Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys
                405                 410                 415     
Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys
            420                 425                 430         
Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg
        435                 440                 445             
Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu
    450                 455                 460                 
Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys
465                 470                 475                 480 
Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala
                485                 490                 495     
Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro
            500                 505                 510         
His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Asp Glu Trp Phe
        515                 520                 525             
Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp
    530                 535                 540                 
Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln
545                 550                 555                 560 
Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr
                565                 570                 575     
Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala
            580                 585                 590         
Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu
        595                 600                 605             
Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg
    610                 615                 620                 
Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala
625                 630                 635                 640 
Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys
                645                 650                 655     
Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp
            660                 665                 670         
Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn
        675                 680                 685             
Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu
    690                 695                 700                 
Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala
705                 710                 715                 720 
Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys
                725                 730                 735     
Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu
            740                 745                 750         
Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr
        755                 760                 765             
Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg
    770                 775                 780                 
Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp
785                 790                 795                 800 
Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu
                805                 810                 815     
Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr
            820                 825                 830         
Pro Leu Met Gln Lys Ile
        835             


<210> 7132
<211> 942
<212> PRT
<213> Homo sapiens

<400> 7132
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
625                 630                 635                 640 
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
                645                 650                 655     
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
            660                 665                 670         
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
        675                 680                 685             
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
    690                 695                 700                 
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
705                 710                 715                 720 
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
                725                 730                 735     
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
            740                 745                 750         
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
        755                 760                 765             
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
    770                 775                 780                 
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
785                 790                 795                 800 
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
                805                 810                 815     
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
            820                 825                 830         
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
        835                 840                 845             
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
    850                 855                 860                 
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr
865                 870                 875                 880 
Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp
                885                 890                 895     
Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Asp
            900                 905                 910         
Glu Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp
        915                 920                 925             
Asp Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
    930                 935                 940         


<210> 7133
<211> 619
<212> PRT
<213> Homo sapiens

<400> 7133
Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu
 1               5                  10                  15      
Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys
            20                  25                  30          
Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val
        35                  40                  45              
Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala
    50                  55                  60                  
Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp
65                  70                  75                  80  
Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His
                85                  90                  95      
Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile
            100                 105                 110         
Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp
        115                 120                 125             
Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp
    130                 135                 140                 
Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp
145                 150                 155                 160 
Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp
                165                 170                 175     
Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp
            180                 185                 190         
Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala
        195                 200                 205             
Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys
    210                 215                 220                 
Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln
225                 230                 235                 240 
Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys
                245                 250                 255     
Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro
            260                 265                 270         
Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr
        275                 280                 285             
Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys
    290                 295                 300                 
Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg
305                 310                 315                 320 
Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val
                325                 330                 335     
Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu
            340                 345                 350         
Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr
        355                 360                 365             
Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser
    370                 375                 380                 
Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala
385                 390                 395                 400 
Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu
                405                 410                 415     
Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly
            420                 425                 430         
Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser
        435                 440                 445             
Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala
    450                 455                 460                 
Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn
465                 470                 475                 480 
Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val
                485                 490                 495     
Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys
            500                 505                 510         
Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser
        515                 520                 525             
Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile
    530                 535                 540                 
Asp Arg Asn Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr Pro Asn Glu
545                 550                 555                 560 
Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp
                565                 570                 575     
Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu Gly Gln
            580                 585                 590         
Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly
        595                 600                 605             
Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
    610                 615                 


<210> 7134
<211> 941
<212> PRT
<213> Homo sapiens

<400> 7134
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe
625                 630                 635                 640 
Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro
                645                 650                 655     
Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro
            660                 665                 670         
Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly
        675                 680                 685             
Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys
    690                 695                 700                 
Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val
705                 710                 715                 720 
Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg
                725                 730                 735     
Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn
            740                 745                 750         
Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr
        755                 760                 765             
Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu
    770                 775                 780                 
Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val
785                 790                 795                 800 
Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala
                805                 810                 815     
Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro
            820                 825                 830         
Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn
        835                 840                 845             
Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu
    850                 855                 860                 
Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Asn Asn Tyr Ser Thr Pro
865                 870                 875                 880 
Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu
                885                 890                 895     
Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu
            900                 905                 910         
Gly Gln Glu Ser Leu Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp
        915                 920                 925             
Glu Gly Gly Gln Val Ser Tyr Pro Ser Met Gln Lys Ile
    930                 935                 940     


<210> 7135
<211> 888
<212> PRT
<213> Homo sapiens

<400> 7135
Met Ala Asn Gly Thr Leu Thr Arg Arg His Gln Asn Gly Arg Phe Val
 1               5                  10                  15      
Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe Ser Asp Leu Lys Leu Asn
            20                  25                  30          
Gly Pro Gln Asp His Ser His Leu Leu Tyr Ser Thr Ile Pro Arg Met
        35                  40                  45              
Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr Thr Glu Glu Asp Pro Glu
    50                  55                  60                  
Gly Ala Met Ser Val Val Ser Val Glu Thr Ser Asp Asp Gly Thr Thr
65                  70                  75                  80  
Arg Arg Thr Glu Thr Thr Val Lys Lys Val Val Lys Thr Val Thr Thr
                85                  90                  95      
Arg Thr Val Gln Pro Val Ala Met Gly Pro Asp Gly Leu Pro Val Asp
            100                 105                 110         
Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln Thr Leu Gly Arg Asp Phe
        115                 120                 125             
Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro Tyr Val Gly Gln Ala Gly
    130                 135                 140                 
Thr Ala Thr Leu Pro Arg Asn Phe His Tyr Pro Pro Asp Gly Tyr Ser
145                 150                 155                 160 
Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly Ser Asp Asn Tyr Gly Ser
                165                 170                 175     
Leu Ser Arg Val Thr Arg Ile Glu Glu Arg Tyr Arg Pro Ser Met Glu
            180                 185                 190         
Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val Tyr Gly Pro Gln Pro Gln
        195                 200                 205             
Val Arg Val Gly Gly Ser Ser Val Asp Leu His Arg Phe His Pro Glu
    210                 215                 220                 
Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser Met Gly Tyr Asp Asp Leu
225                 230                 235                 240 
Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr Ala Arg Arg Thr Gly Thr
                245                 250                 255     
Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser Tyr Glu Asp Met Ile Gly
            260                 265                 270         
Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp Ala Pro Leu Ala Gln His
        275                 280                 285             
Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser Leu Arg Lys Gly Gly Pro
    290                 295                 300                 
Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu Pro Glu Val Ile Ala Met
305                 310                 315                 320 
Leu Gly Phe Arg Leu Asp Ala Val Lys Ser Asn Ala Ala Ala Tyr Leu
                325                 330                 335     
Gln His Leu Cys Tyr Arg Asn Asp Lys Val Lys Thr Asp Val Arg Lys
            340                 345                 350         
Leu Lys Gly Ile Pro Val Leu Val Gly Leu Leu Asp His Pro Lys Lys
        355                 360                 365             
Glu Val His Leu Gly Ala Cys Gly Ala Leu Lys Asn Ile Ser Phe Gly
    370                 375                 380                 
Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys Asn Cys Asp Gly Val Pro
385                 390                 395                 400 
Ala Leu Val Arg Leu Leu Arg Lys Ala Arg Asp Met Asp Leu Thr Glu
                405                 410                 415     
Val Ile Thr Gly Thr Leu Trp Asn Leu Ser Ser His Asp Ser Ile Lys
            420                 425                 430         
Met Glu Ile Val Asp His Ala Leu His Ala Leu Thr Asp Glu Val Ile
        435                 440                 445             
Ile Pro His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Cys Lys Pro
    450                 455                 460                 
Arg His Ile Glu Trp Glu Ser Val Leu Thr Asn Thr Ala Gly Cys Leu
465                 470                 475                 480 
Arg Asn Val Ser Ser Glu Arg Ser Glu Ala Arg Arg Lys Leu Arg Glu
                485                 490                 495     
Cys Asp Gly Leu Val Asp Ala Leu Ile Phe Ile Val Gln Ala Glu Ile
            500                 505                 510         
Gly Gln Lys Asp Ser Asp Ser Lys Leu Val Glu Asn Cys Val Cys Leu
        515                 520                 525             
Leu Arg Asn Leu Ser Tyr Gln Val His Arg Glu Ile Pro Gln Ala Glu
    530                 535                 540                 
Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala Asn Asn Thr Gly Pro His
545                 550                 555                 560 
Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly Lys Gly Lys Lys Pro Ile
                565                 570                 575     
Glu Asp Pro Ala Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro
            580                 585                 590         
Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr
        595                 600                 605             
Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser
    610                 615                 620                 
Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg
625                 630                 635                 640 
Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala
                645                 650                 655     
Asp Leu Leu Thr Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly
            660                 665                 670         
Ala Leu Arg Asn Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly
        675                 680                 685             
Lys His Ala Ile Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln
    690                 695                 700                 
Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn
705                 710                 715                 720 
Thr Ile Asn Glu Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu
                725                 730                 735     
Arg Glu Thr Gln Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly
            740                 745                 750         
Asn Arg Ser Glu Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr
        755                 760                 765             
Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp
    770                 775                 780                 
Lys Lys Ser Asp Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln
785                 790                 795                 800 
Ser Ser His Ser Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn
                805                 810                 815     
Gln Lys Ser Asp Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp
            820                 825                 830         
His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro
        835                 840                 845             
Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu
    850                 855                 860                 
Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val
865                 870                 875                 880 
Ser Tyr Pro Ser Met Gln Lys Ile
                885             


<210> 7136
<211> 968
<212> PRT
<213> Homo sapiens

<400> 7136
Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val
 1               5                  10                  15      
Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu
            20                  25                  30          
Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro
        35                  40                  45              
Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His
    50                  55                  60                  
Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe
65                  70                  75                  80  
Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr
                85                  90                  95      
Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr
            100                 105                 110         
Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr
        115                 120                 125             
Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val
    130                 135                 140                 
Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro
145                 150                 155                 160 
Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln
                165                 170                 175     
Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro
            180                 185                 190         
Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr
        195                 200                 205             
Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly
    210                 215                 220                 
Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg
225                 230                 235                 240 
Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val
                245                 250                 255     
Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu
            260                 265                 270         
His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser
        275                 280                 285             
Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr
    290                 295                 300                 
Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser
305                 310                 315                 320 
Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp
                325                 330                 335     
Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser
            340                 345                 350         
Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu
        355                 360                 365             
Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser
    370                 375                 380                 
Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val
385                 390                 395                 400 
Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu
                405                 410                 415     
Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu
            420                 425                 430         
Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys
        435                 440                 445             
Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg
    450                 455                 460                 
Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser
465                 470                 475                 480 
Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala
                485                 490                 495     
Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro
            500                 505                 510         
Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr
        515                 520                 525             
Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala
    530                 535                 540                 
Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe
545                 550                 555                 560 
Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val
                565                 570                 575     
Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg
            580                 585                 590         
Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala
        595                 600                 605             
Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly
    610                 615                 620                 
Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala
625                 630                 635                 640 
Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr
                645                 650                 655     
Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu
            660                 665                 670         
Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile
        675                 680                 685             
Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser
    690                 695                 700                 
Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr
705                 710                 715                 720 
Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn
                725                 730                 735     
Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile
            740                 745                 750         
Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp
        755                 760                 765             
Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu
    770                 775                 780                 
Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln
785                 790                 795                 800 
Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu
                805                 810                 815     
Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr
            820                 825                 830         
Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp
        835                 840                 845             
Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser
    850                 855                 860                 
Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp
865                 870                 875                 880 
Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn
                885                 890                 895     
Thr Lys Ser Leu Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp
            900                 905                 910         
His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro
        915                 920                 925             
Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu
    930                 935                 940                 
Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val
945                 950                 955                 960 
Ser Tyr Pro Ser Met Gln Lys Ile
                965             


<210> 7137
<211> 115
<212> PRT
<213> Homo sapiens

<400> 7137
Met Asp Gly Glu Glu Lys Thr Cys Gly Gly Cys Glu Gly Pro Asp Ala
 1               5                  10                  15      
Met Tyr Val Lys Leu Ile Ser Ser Asp Gly His Glu Phe Ile Val Lys
            20                  25                  30          
Arg Glu His Ala Leu Thr Ser Gly Thr Ile Lys Thr Thr Leu Gly Gly
        35                  40                  45              
Pro Gly Gln Ser Ala Val Asn Glu Thr Asn Glu Val Asn Phe Arg Glu
    50                  55                  60                  
Ile Pro Ser Arg Val Leu Ser Lys Val Cys Thr Tyr Phe Met Tyr Lys
65                  70                  75                  80  
Val Arg Tyr Pro Asn Ser Ser Thr Glu Val Pro Glu Leu Pro Ile Ala
                85                  90                  95      
Pro Glu Ile Ala Leu Glu Leu Leu Met Asp Val Ser Phe Leu Asp Cys
            100                 105                 110         
Glu Ile Lys
        115 


<210> 7138
<211> 351
<212> PRT
<213> Homo sapiens

<400> 7138
Met Glu Asp Ser Gln Glu Thr Ser Pro Ser Ser Asn Asn Ser Ser Glu
 1               5                  10                  15      
Glu Leu Ser Ser Ala Leu His Leu Ser Lys Gly Met Ser Ile Phe Leu
            20                  25                  30          
Asp Ile Leu Arg Arg Ala Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe
        35                  40                  45              
Glu Glu Phe Lys Ala Tyr Phe Ala Asp Gly Val Leu Ser Gly Glu Glu
    50                  55                  60                  
Leu His Glu Leu Phe His Thr Ile Asp Thr His Asn Thr Asn Asn Leu
65                  70                  75                  80  
Asp Thr Glu Glu Leu Cys Glu Tyr Phe Ser Gln His Leu Gly Glu Tyr
                85                  90                  95      
Glu Asn Val Leu Ala Ala Leu Glu Asp Leu Asn Leu Ser Ile Leu Lys
            100                 105                 110         
Ala Met Gly Lys Thr Lys Lys Asp Tyr Gln Glu Ala Ser Asn Leu Glu
        115                 120                 125             
Gln Phe Val Thr Arg Phe Leu Leu Lys Glu Thr Leu Asn Gln Leu Gln
    130                 135                 140                 
Ser Leu Gln Asn Ser Leu Glu Cys Ala Met Glu Thr Thr Glu Glu Gln
145                 150                 155                 160 
Thr Arg Gln Glu Arg Gln Gly Pro Ala Lys Pro Glu Val Leu Ser Ile
                165                 170                 175     
Gln Trp Pro Gly Lys Arg Ser Ser Arg Arg Val Gln Arg His Asn Ser
            180                 185                 190         
Phe Ser Pro Asn Ser Pro Gln Phe Asn Val Ser Gly Pro Gly Leu Leu
        195                 200                 205             
Glu Glu Asp Asn Gln Trp Met Thr Gln Ile Asn Arg Leu Gln Lys Leu
    210                 215                 220                 
Ile Asp Arg Leu Glu Lys Lys Asp Leu Lys Leu Glu Pro Pro Glu Glu
225                 230                 235                 240 
Glu Ile Ile Glu Gly Asn Thr Lys Ser His Ile Met Leu Val Gln Arg
                245                 250                 255     
Gln Met Ser Val Ile Glu Glu Asp Leu Glu Glu Phe Gln Leu Ala Leu
            260                 265                 270         
Lys His Tyr Val Glu Ser Ala Ser Ser Gln Ser Gly Cys Leu Arg Ile
        275                 280                 285             
Ser Ile Gln Lys Leu Ser Asn Glu Ser Arg Tyr Met Ile Tyr Glu Phe
    290                 295                 300                 
Trp Glu Asn Ser Ser Val Trp Asn Ser His Leu Gln Thr Asn Tyr Ser
305                 310                 315                 320 
Lys Thr Phe Gln Arg Ser Asn Val Asp Phe Leu Glu Thr Pro Glu Leu
                325                 330                 335     
Thr Ser Thr Met Leu Val Pro Ala Ser Trp Trp Ile Leu Asn Asn
            340                 345                 350     


<210> 7139
<211> 958
<212> PRT
<213> Homo sapiens

<400> 7139
Met Ser Glu Cys Gly Gly Arg Gly Gly Gly Ser Ser Ser Ser Glu Asp
 1               5                  10                  15      
Ala Glu Asp Glu Gly Gly Gly Gly Gly Gly Pro Ala Gly Ser Asp Cys
            20                  25                  30          
Leu Ser Ser Ser Pro Thr Leu Ala Thr Ala Ser Ser Ala Gly Arg Leu
        35                  40                  45              
Arg Arg Gly Leu Arg Gly Ala Phe Leu Met Ala Arg Gln Arg Pro Glu
    50                  55                  60                  
Leu Leu Cys Gly Ala Val Ala Leu Gly Cys Ala Leu Leu Leu Ala Leu
65                  70                  75                  80  
Lys Phe Thr Cys Ser Arg Ala Lys Asp Val Ile Ile Pro Ala Lys Pro
                85                  90                  95      
Pro Val Ser Phe Phe Ser Leu Arg Ser Pro Val Leu Asp Leu Phe Gln
            100                 105                 110         
Gly Gln Leu Asp Tyr Ala Glu Tyr Val Arg Arg Asp Ser Glu Val Val
        115                 120                 125             
Leu Leu Phe Phe Tyr Ala Pro Trp Cys Gly Gln Ser Ile Ala Ala Arg
    130                 135                 140                 
Ala Glu Ile Glu Gln Ala Ala Ser Arg Leu Ser Asp Gln Val Leu Phe
145                 150                 155                 160 
Val Ala Ile Asn Cys Trp Trp Asn Gln Gly Lys Cys Arg Lys Gln Lys
                165                 170                 175     
His Phe Phe Tyr Phe Pro Val Ile Tyr Leu Tyr His Arg Ser Phe Gly
            180                 185                 190         
Pro Ile Glu Tyr Lys Gly Pro Met Ser Ala Val Tyr Ile Glu Lys Phe
        195                 200                 205             
Val Arg Arg Val Met Lys Pro Leu Leu Tyr Ile Pro Ser Gln Ser Glu
    210                 215                 220                 
Leu Leu Asp Phe Leu Ser Asn Tyr Glu Pro Gly Val Leu Gly Tyr Phe
225                 230                 235                 240 
Glu Phe Ser Gly Ser Pro Gln Pro Pro Gly Tyr Leu Thr Phe Phe Thr
                245                 250                 255     
Ser Ala Leu His Ser Leu Lys Lys Asp Tyr Leu Gly Thr Val Arg Phe
            260                 265                 270         
Gly Val Ile Thr Asn Lys His Leu Ala Lys Leu Val Ser Leu Val His
        275                 280                 285             
Ser Gly Ser Val Tyr Leu His Arg His Phe Asn Thr Ser Leu Val Phe
    290                 295                 300                 
Pro Arg Glu Val Leu Asn Tyr Thr Ala Glu Asn Ile Cys Lys Trp Ala
305                 310                 315                 320 
Leu Glu Asn Gln Glu Thr Leu Phe Arg Trp Leu Arg Pro His Gly Gly
                325                 330                 335     
Lys Ser Leu Leu Leu Asn Asn Glu Leu Lys Lys Gly Pro Ala Leu Phe
            340                 345                 350         
Leu Phe Ile Pro Phe Asn Pro Leu Ala Glu Ser His Pro Leu Ile Asp
        355                 360                 365             
Glu Ile Thr Glu Val Ala Leu Glu Tyr Asn Asn Cys His Gly Asp Gln
    370                 375                 380                 
Val Val Glu Arg Leu Leu Gln His Leu Arg Arg Val Asp Ala Pro Val
385                 390                 395                 400 
Leu Glu Ser Leu Ala Leu Glu Val Pro Ala Gln Leu Pro Asp Pro Pro
                405                 410                 415     
Thr Ile Thr Ala Ser Pro Cys Cys Asn Thr Val Val Leu Pro Gln Trp
            420                 425                 430         
His Ser Phe Ser Arg Thr His Asn Val Cys Glu Leu Cys Val Asn Gln
        435                 440                 445             
Thr Ser Gly Gly Met Lys Pro Ser Ser Val Ser Val Pro Gln Cys Ser
    450                 455                 460                 
Phe Phe Glu Met Ala Ala Ala Leu Asp Ser Phe Tyr Leu Lys Glu Gln
465                 470                 475                 480 
Thr Phe Tyr His Val Ala Ser Asp Ser Ile Glu Cys Ser Asn Phe Leu
                485                 490                 495     
Thr Ser Tyr Ser Pro Phe Ser Tyr Tyr Thr Ala Cys Cys Arg Thr Ile
            500                 505                 510         
Ser Arg Gly Val Ser Gly Phe Ile Asp Ser Glu Gln Gly Val Phe Glu
        515                 520                 525             
Ala Pro Thr Val Ala Phe Ser Ser Leu Glu Lys Lys Cys Glu Val Asp
    530                 535                 540                 
Ala Pro Ser Ser Val Pro His Ile Glu Glu Asn Arg Tyr Leu Phe Pro
545                 550                 555                 560 
Glu Val Asp Met Thr Ser Thr Asn Phe Thr Gly Leu Ser Cys Arg Thr
                565                 570                 575     
Asn Lys Thr Leu Asn Ile Tyr Leu Leu Asp Ser Asn Leu Phe Trp Leu
            580                 585                 590         
Tyr Ala Glu Arg Leu Gly Ala Pro Ser Ser Thr Gln Val Lys Glu Phe
        595                 600                 605             
Ala Ala Ile Val Asp Val Lys Glu Glu Ser His Tyr Ile Leu Asp Pro
    610                 615                 620                 
Lys Gln Ala Leu Met Lys Leu Thr Leu Glu Ser Phe Ile Gln Asn Phe
625                 630                 635                 640 
Ser Val Leu Tyr Ser Pro Leu Lys Arg His Leu Ile Gly Ser Gly Ser
                645                 650                 655     
Ala Gln Phe Pro Ser Gln His Leu Ile Thr Glu Val Thr Thr Asp Thr
            660                 665                 670         
Phe Trp Glu Val Val Leu Gln Lys Gln Asp Val Leu Leu Leu Tyr Tyr
        675                 680                 685             
Ala Pro Trp Cys Gly Phe Cys Pro Ser Leu Asn His Ile Phe Ile Gln
    690                 695                 700                 
Leu Ala Arg Asn Leu Pro Met Asp Thr Phe Thr Val Ala Arg Ile Asp
705                 710                 715                 720 
Val Ser Gln Asn Asp Leu Pro Trp Glu Phe Met Val Asp Arg Leu Pro
                725                 730                 735     
Thr Val Leu Phe Phe Pro Cys Asn Arg Lys Asp Leu Ser Val Lys Tyr
            740                 745                 750         
Pro Glu Asp Val Pro Ile Thr Leu Pro Asn Leu Leu Arg Phe Ile Leu
        755                 760                 765             
His His Ser Asp Pro Ala Ser Ser Pro Gln Asn Val Ala Asn Ser Pro
    770                 775                 780                 
Thr Lys Glu Cys Leu Gln Ser Glu Ala Val Leu Gln Arg Gly His Ile
785                 790                 795                 800 
Ser His Leu Glu Arg Glu Ile Gln Lys Leu Arg Ala Glu Ile Ser Ser
                805                 810                 815     
Leu Gln Arg Ala Gln Val Gln Val Glu Ser Gln Leu Ser Ser Ala Arg
            820                 825                 830         
Arg Asp Glu His Arg Leu Arg Gln Gln Gln Arg Ala Leu Glu Glu Gln
        835                 840                 845             
His Ser Leu Leu His Ala His Ser Glu Gln Leu Gln Ala Leu Tyr Glu
    850                 855                 860                 
Gln Lys Thr Arg Glu Leu Gln Glu Leu Ala Arg Lys Leu Gln Glu Leu
865                 870                 875                 880 
Ala Asp Ala Ser Glu Asn Leu Leu Thr Glu Asn Thr Trp Leu Lys Ile
                885                 890                 895     
Leu Val Ala Thr Met Glu Arg Lys Leu Glu Gly Arg Asp Gly Ala Glu
            900                 905                 910         
Ser Leu Ala Ala Gln Arg Glu Val His Pro Lys Gln Pro Glu Pro Ser
        915                 920                 925             
Ala Thr Pro Gln Leu Pro Gly Ser Ser Pro Pro Pro Ala Asn Val Ser
    930                 935                 940                 
Ala Thr Leu Val Ser Glu Arg Asn Lys Glu Asn Arg Thr Asp
945                 950                 955             


<210> 7140
<211> 210
<212> PRT
<213> Homo sapiens

<400> 7140
Met Lys Pro Ser Ser Val Ser Val Pro Gln Cys Ser Phe Phe Glu Met
 1               5                  10                  15      
Ala Ala Ala Leu Asp Ser Phe Tyr Leu Lys Glu Gln Thr Phe Tyr His
            20                  25                  30          
Val Ala Ser Asp Ser Ile Glu Cys Ser Asn Phe Leu Thr Ser Tyr Ser
        35                  40                  45              
Pro Phe Ser Tyr Tyr Thr Ala Cys Cys Arg Thr Ile Ser Arg Gly Val
    50                  55                  60                  
Ser Gly Phe Ile Asp Ser Glu Gln Gly Val Phe Glu Ala Pro Thr Val
65                  70                  75                  80  
Ala Phe Ser Ser Leu Glu Lys Lys Cys Glu Val Asp Ala Pro Ser Ser
                85                  90                  95      
Val Pro His Ile Glu Glu Asn Arg Tyr Leu Phe Pro Glu Val Asp Met
            100                 105                 110         
Thr Ser Thr Asn Phe Thr Gly Leu Ser Cys Arg Thr Asn Lys Thr Leu
        115                 120                 125             
Asn Ile Tyr Leu Leu Asp Ser Asn Leu Phe Trp Leu Tyr Ala Glu Arg
    130                 135                 140                 
Leu Gly Ala Pro Ser Ser Thr Gln Val Lys Glu Phe Ala Ala Ile Val
145                 150                 155                 160 
Asp Val Lys Glu Glu Ser His Tyr Ile Leu Asp Pro Lys Gln Ala Leu
                165                 170                 175     
Met Lys Leu Thr Leu Gly Thr Ala Gly Ser Leu Phe Pro Gln Ala Leu
            180                 185                 190         
Tyr Ile Leu Leu Asp Phe Ile Trp Val Asn Phe Ile Asp Gly Ser His
        195                 200                 205             
Tyr Ile
    210 


<210> 7141
<211> 359
<212> PRT
<213> Homo sapiens

<400> 7141
Met Ala Glu Pro Phe Leu Ser Glu Tyr Gln His Gln Pro Gln Thr Ser
 1               5                  10                  15      
Asn Cys Thr Gly Ala Ala Ala Val Gln Glu Glu Leu Asn Pro Glu Arg
            20                  25                  30          
Pro Pro Gly Ala Glu Glu Arg Val Pro Glu Glu Asp Ser Arg Trp Gln
        35                  40                  45              
Ser Arg Ala Phe Pro Gln Leu Gly Gly Arg Pro Gly Pro Glu Gly Glu
    50                  55                  60                  
Gly Ser Leu Glu Ser Gln Pro Pro Pro Leu Gln Thr Gln Ala Cys Pro
65                  70                  75                  80  
Glu Ser Ser Cys Leu Arg Glu Gly Glu Lys Gly Gln Asn Gly Asp Asp
                85                  90                  95      
Ser Ser Ala Gly Gly Asp Phe Pro Pro Pro Ala Glu Val Glu Pro Thr
            100                 105                 110         
Pro Glu Ala Glu Leu Leu Ala Gln Pro Cys His Asp Ser Glu Ala Ser
        115                 120                 125             
Lys Leu Gly Ala Pro Ala Ala Gly Gly Glu Glu Glu Trp Gly Gln Gln
    130                 135                 140                 
Gln Arg Gln Leu Gly Lys Lys Lys His Arg Arg Arg Pro Ser Lys Lys
145                 150                 155                 160 
Lys Arg His Trp Lys Pro Tyr Tyr Lys Leu Thr Trp Glu Glu Lys Lys
                165                 170                 175     
Lys Phe Asp Glu Lys Gln Ser Leu Arg Ala Ser Arg Ile Arg Ala Glu
            180                 185                 190         
Met Phe Ala Lys Gly Gln Pro Val Ala Pro Tyr Asn Thr Thr Gln Phe
        195                 200                 205             
Leu Met Asp Asp His Asp Gln Glu Glu Pro Asp Leu Lys Thr Gly Leu
    210                 215                 220                 
Tyr Ser Lys Arg Ala Ala Ala Lys Ser Asp Asp Thr Ser Asp Asp Asp
225                 230                 235                 240 
Phe Met Glu Glu Gly Gly Glu Glu Asp Gly Gly Ser Asp Gly Met Gly
                245                 250                 255     
Gly Asp Gly Ser Glu Phe Leu Gln Arg Asp Phe Ser Glu Thr Tyr Glu
            260                 265                 270         
Arg Tyr His Thr Glu Ser Leu Gln Asn Met Ser Lys Gln Glu Leu Ile
        275                 280                 285             
Lys Glu Tyr Leu Glu Leu Glu Lys Cys Leu Ser Arg Met Glu Asp Glu
    290                 295                 300                 
Asn Asn Arg Leu Arg Leu Glu Ser Lys Arg Leu Gly Gly Asp Asp Ala
305                 310                 315                 320 
Arg Val Arg Glu Leu Glu Leu Glu Leu Asp Arg Leu Arg Ala Glu Asn
                325                 330                 335     
Leu Gln Leu Leu Thr Glu Asn Glu Leu His Arg Gln Gln Glu Arg Ala
            340                 345                 350         
Pro Leu Ser Lys Phe Gly Asp
        355                 


<210> 7142
<211> 452
<212> PRT
<213> Homo sapiens

<400> 7142
Glu Phe Val Thr Ala Leu Ala Asp Leu Arg Ala Glu Ala Ser Cys Pro
 1               5                  10                  15      
Ile Cys Leu Asp Tyr Leu Lys Asp Pro Val Thr Ile Ser Cys Gly His
            20                  25                  30          
Asn Phe Cys Leu Ser Cys Ile Ile Met Ser Trp Lys Asp Leu His Asp
        35                  40                  45              
Ser Phe Pro Cys Pro Phe Cys His Phe Cys Cys Pro Glu Arg Lys Phe
    50                  55                  60                  
Ile Ser Asn Pro Gln Leu Gly Ser Leu Thr Glu Ile Ala Lys Gln Leu
65                  70                  75                  80  
Gln Ile Arg Ser Lys Lys Arg Lys Arg Gln Glu Glu Lys His Val Cys
                85                  90                  95      
Lys Lys His Asn Gln Val Leu Thr Phe Phe Cys Gln Lys Asp Leu Glu
            100                 105                 110         
Leu Leu Cys Pro Arg Cys Ser Leu Ser Thr Asp His Gln His His Cys
        115                 120                 125             
Val Trp Pro Ile Lys Lys Ala Ala Ser Tyr His Arg Lys Lys Leu Glu
    130                 135                 140                 
Glu Tyr Asn Ala Pro Trp Lys Glu Arg Val Glu Leu Ile Glu Lys Val
145                 150                 155                 160 
Ile Thr Met Gln Thr Arg Lys Ser Leu Glu Leu Lys Lys Lys Val Lys
                165                 170                 175     
His Arg Ala Glu Glu Val Lys Ser Glu Phe Glu Gln Leu Arg Leu Phe
            180                 185                 190         
Leu Gln Asn Glu Gln Glu Thr Val Leu Arg Gln Leu Gln Asp Glu Glu
        195                 200                 205             
Met Asp Ile Leu Ala Gln Leu Asn Glu Ser Leu Thr Lys Phe Ser Asp
    210                 215                 220                 
Tyr Thr Ser Ser Leu Lys Tyr Leu Leu Lys Glu Ile Glu Ser Ile Tyr
225                 230                 235                 240 
Val Lys Ser Glu Leu Glu Leu Leu Ala Asn Val Lys Asp Ile Tyr His
                245                 250                 255     
Arg Tyr Glu Asn Leu Lys Phe Pro Glu Leu Phe Leu Phe Lys Leu Lys
            260                 265                 270         
Lys Tyr Gly Tyr His Leu Pro Pro Gln Tyr Ser Gly Leu Asp Lys Ile
        275                 280                 285             
Ile Lys Arg Phe Gln Val Asp Val Ile Leu Asp Pro Glu Thr Ala His
    290                 295                 300                 
Arg Lys Leu Ile Val Ser Glu Asp Arg Lys Thr Val Arg Tyr Gly Asn
305                 310                 315                 320 
Thr Thr Gln Asn Val Pro His Asn Pro Arg Arg Phe Tyr Leu Leu Pro
                325                 330                 335     
Ala Val Leu Gly Ser Lys Gly Tyr Ser Cys Gly Arg Gln Tyr Trp Glu
            340                 345                 350         
Val Glu Val Lys Asp Lys Pro Glu Trp Ile Leu Gly Val Cys Asn Asp
        355                 360                 365             
Cys Leu Pro Arg Arg Arg Lys Ser Gln Pro Ile Leu Val Gln Asp Gly
    370                 375                 380                 
Leu Trp Gly Ile Trp Arg Ser Ser Gln Asn Asn Tyr Ile Val Leu Gly
385                 390                 395                 400 
His Arg Glu Ile Ile Leu Leu Pro Gln Val Ile Pro Ser Lys Ile Gly
                405                 410                 415     
Ile Phe Leu Asp Tyr Glu Met Asn Glu Val Ser Phe Tyr Asn Leu Asn
            420                 425                 430         
Asp Arg Ser Leu Leu Tyr Thr Phe Asn Asp Asn Phe Thr Gly Ala Leu
        435                 440                 445             
Trp Pro Tyr Phe
    450         


<210> 7143
<211> 684
<212> PRT
<213> Homo sapiens

<400> 7143
Met Gln Ser Arg Glu Asp Val Pro Arg Ser Arg Arg Leu Ala Ser Pro
 1               5                  10                  15      
Arg Gly Gly Arg Arg Pro Lys Arg Ile Ser Lys Pro Ser Val Ser Ala
            20                  25                  30          
Phe Phe Thr Gly Pro Glu Glu Leu Lys Asp Thr Ala His Ser Ala Ala
        35                  40                  45              
Leu Leu Ala Gln Leu Lys Ser Phe Tyr Asp Ala Arg Leu Leu Cys Asp
    50                  55                  60                  
Val Thr Ile Glu Val Val Thr Pro Gly Ser Gly Pro Gly Thr Gly Arg
65                  70                  75                  80  
Leu Phe Ser Cys Asn Arg Asn Val Leu Ala Ala Ala Cys Pro Tyr Phe
                85                  90                  95      
Lys Ser Met Phe Thr Gly Gly Met Tyr Glu Ser Gln Gln Ala Ser Val
            100                 105                 110         
Thr Met His Asp Val Asp Ala Glu Ser Phe Glu Val Leu Val Asp Tyr
        115                 120                 125             
Cys Tyr Thr Gly Arg Val Ser Leu Ser Glu Ala Asn Val Gln Arg Leu
    130                 135                 140                 
Tyr Ala Ala Ser Asp Met Leu Gln Leu Glu Tyr Val Arg Glu Ala Cys
145                 150                 155                 160 
Ala Ser Phe Leu Ala Arg Arg Leu Asp Leu Thr Asn Cys Thr Ala Ile
                165                 170                 175     
Leu Lys Phe Ala Asp Ala Phe Asp His His Lys Leu Arg Ser Gln Ala
            180                 185                 190         
Gln Ser Tyr Ile Ala His Asn Phe Lys Gln Leu Ser Arg Met Gly Ser
        195                 200                 205             
Ile Arg Glu Glu Thr Leu Ala Asp Leu Thr Leu Ala Gln Leu Leu Ala
    210                 215                 220                 
Val Leu Arg Leu Asp Ser Leu Asp Ile Glu Ser Glu Arg Thr Val Cys
225                 230                 235                 240 
His Val Ala Val Gln Trp Leu Glu Ala Ala Ala Lys Glu Arg Gly Pro
                245                 250                 255     
Ser Ala Ala Glu Val Phe Lys Cys Val Arg Trp Met His Phe Thr Glu
            260                 265                 270         
Glu Asp Gln Asp Tyr Leu Glu Gly Leu Leu Thr Lys Pro Ile Val Lys
        275                 280                 285             
Lys Tyr Cys Leu Asp Val Ile Glu Gly Ala Leu Gln Met Arg Tyr Gly
    290                 295                 300                 
Asp Leu Leu Tyr Lys Ser Leu Val Pro Val Pro Asn Ser Ser Ser Ser
305                 310                 315                 320 
Ser Ser Ser Ser Asn Ser Leu Val Ser Ala Ala Glu Asn Pro Pro Gln
                325                 330                 335     
Arg Leu Gly Met Cys Ala Lys Glu Met Val Ile Phe Phe Gly His Pro
            340                 345                 350         
Arg Asp Pro Phe Leu Cys Tyr Asp Pro Tyr Ser Gly Asp Ile Tyr Thr
        355                 360                 365             
Met Pro Ser Pro Leu Thr Ser Phe Ala His Thr Lys Thr Val Thr Ser
    370                 375                 380                 
Ser Ala Val Cys Val Ser Pro Asp His Asp Ile Tyr Leu Ala Ala Gln
385                 390                 395                 400 
Pro Arg Lys Asp Leu Trp Val Tyr Lys Pro Ala Gln Asn Ser Trp Gln
                405                 410                 415     
Gln Leu Ala Asp Arg Leu Leu Cys Arg Glu Gly Met Asp Val Ala Tyr
            420                 425                 430         
Leu Asn Gly Tyr Ile Tyr Ile Leu Gly Gly Arg Asp Pro Ile Thr Gly
        435                 440                 445             
Val Lys Leu Lys Glu Val Glu Cys Tyr Ser Val Gln Arg Asn Gln Trp
    450                 455                 460                 
Ala Leu Val Ala Pro Val Pro His Ser Phe Tyr Ser Phe Glu Leu Ile
465                 470                 475                 480 
Val Val Gln Asn Tyr Leu Tyr Ala Val Asn Ser Lys Arg Met Leu Cys
                485                 490                 495     
Tyr Asp Pro Ser His Asn Met Trp Leu Asn Cys Ala Ser Leu Lys Arg
            500                 505                 510         
Ser Asp Phe Gln Glu Ala Cys Val Phe Asn Asp Glu Ile Tyr Cys Ile
        515                 520                 525             
Cys Asp Ile Pro Val Met Lys Val Tyr Asn Pro Ala Arg Gly Glu Trp
    530                 535                 540                 
Arg Arg Ile Ser Asn Ile Pro Leu Asp Ser Glu Thr His Asn Tyr Gln
545                 550                 555                 560 
Ile Val Asn His Asp Gln Lys Leu Leu Leu Ile Thr Ser Thr Thr Pro
                565                 570                 575     
Gln Trp Lys Lys Asn Arg Val Thr Val Tyr Glu Tyr Asp Thr Arg Glu
            580                 585                 590         
Asp Gln Trp Ile Asn Ile Gly Thr Met Ser Gly Leu Leu Gln Phe Asp
        595                 600                 605             
Ser Gly Phe Ile Cys Leu Cys Ala Arg Val Tyr Pro Ser Tyr Leu Glu
    610                 615                 620                 
Pro Gly Gln Ser Phe Ile Thr Glu Glu Asp Asp Ala Arg Ser Glu Ser
625                 630                 635                 640 
Ser Thr Glu Trp Asp Leu Asp Gly Phe Ser Glu Leu Asp Ser Glu Ser
                645                 650                 655     
Gly Ser Ser Ser Ser Phe Ser Asp Asp Glu Val Trp Val Gln Val Ala
            660                 665                 670         
Pro Gln Arg Asn Ala Gln Asp Gln Gln Gly Ser Leu
        675                 680                 


<210> 7144
<211> 674
<212> PRT
<213> Homo sapiens

<400> 7144
Met Gln Ser Arg Glu Asp Ala Pro Arg Ser Arg Arg Leu Ala Ser Pro
 1               5                  10                  15      
Arg Gly Gly Lys Arg Pro Lys Lys Ile His Lys Pro Thr Val Ser Ala
            20                  25                  30          
Phe Phe Thr Gly Pro Glu Glu Leu Lys Asp Thr Ala His Ser Ala Ala
        35                  40                  45              
Leu Leu Ala Gln Leu Lys Ser Phe Tyr Asp Ala Arg Leu Leu Cys Asp
    50                  55                  60                  
Val Thr Ile Glu Val Val Thr Pro Gly Ser Gly Pro Gly Thr Gly Arg
65                  70                  75                  80  
Leu Phe Pro Cys Asn Arg Asn Val Leu Ala Ala Ala Cys Pro Tyr Phe
                85                  90                  95      
Lys Ser Met Phe Thr Gly Gly Met Tyr Glu Ser Gln Gln Ala Ser Val
            100                 105                 110         
Thr Met His Asp Val Asp Ala Glu Ser Phe Glu Val Leu Val Asp Tyr
        115                 120                 125             
Cys Tyr Thr Gly Arg Val Ser Leu Ser Glu Ala Asn Val Glu Arg Leu
    130                 135                 140                 
Tyr Ala Ala Ser Asp Met Leu Gln Leu Glu Tyr Val Arg Glu Ala Cys
145                 150                 155                 160 
Ala Ser Phe Leu Ala Arg Arg Leu Asp Leu Thr Asn Cys Thr Ala Ile
                165                 170                 175     
Leu Lys Phe Ala Asp Ala Phe Gly His Arg Lys Leu Arg Ser Gln Ala
            180                 185                 190         
Gln Ser Tyr Ile Ala Gln Asn Phe Lys Gln Leu Ser His Met Gly Ser
        195                 200                 205             
Ile Arg Glu Glu Thr Leu Ala Asp Leu Thr Leu Ala Gln Leu Leu Ala
    210                 215                 220                 
Val Leu Arg Leu Asp Ser Leu Asp Val Glu Ser Glu Gln Thr Val Cys
225                 230                 235                 240 
His Val Ala Val Gln Trp Leu Glu Ala Ala Pro Lys Glu Arg Gly Pro
                245                 250                 255     
Ser Ala Ala Glu Val Phe Lys Cys Val Arg Trp Met His Phe Thr Glu
            260                 265                 270         
Glu Asp Gln Asp Tyr Leu Glu Gly Leu Leu Thr Lys Pro Ile Val Lys
        275                 280                 285             
Lys Tyr Cys Leu Asp Val Ile Glu Gly Ala Leu Gln Met Arg Tyr Gly
    290                 295                 300                 
Asp Leu Leu Tyr Lys Ser Leu Val Pro Val Pro Asn Ser Ser Ser Ser
305                 310                 315                 320 
Ser Ser Ser Ser Asn Ser Leu Val Ser Ala Ala Glu Asn Pro Pro Gln
                325                 330                 335     
Arg Leu Gly Met Cys Ala Lys Glu Met Val Ile Phe Phe Gly His Pro
            340                 345                 350         
Arg Asp Pro Phe Leu Cys Cys Asp Pro Tyr Ser Gly Asp Leu Tyr Lys
        355                 360                 365             
Val Pro Ser Pro Leu Thr Cys Leu Ala His Thr Arg Thr Val Thr Thr
    370                 375                 380                 
Leu Ala Val Cys Ile Ser Pro Asp His Asp Ile Tyr Leu Ala Ala Gln
385                 390                 395                 400 
Pro Arg Thr Asp Leu Trp Val Tyr Lys Pro Ala Gln Asn Ser Trp Gln
                405                 410                 415     
Gln Leu Ala Asp Arg Leu Leu Cys Arg Glu Gly Met Asp Val Ala Tyr
            420                 425                 430         
Leu Asn Gly Tyr Ile Tyr Ile Leu Gly Gly Arg Asp Pro Ile Thr Gly
        435                 440                 445             
Val Lys Leu Lys Glu Val Glu Cys Tyr Asn Val Lys Arg Asn Gln Trp
    450                 455                 460                 
Ala Leu Val Ala Pro Leu Pro His Ser Phe Leu Ser Phe Asp Leu Met
465                 470                 475                 480 
Val Ile Arg Asp Tyr Leu Tyr Ala Leu Asn Ser Lys Arg Met Phe Cys
                485                 490                 495     
Tyr Asp Pro Ser His Asn Met Trp Leu Lys Cys Val Ser Leu Lys Arg
            500                 505                 510         
Asn Asp Phe Gln Glu Ala Cys Val Phe Asn Glu Glu Ile Tyr Cys Ile
        515                 520                 525             
Cys Asp Ile Pro Val Met Lys Val Tyr Asn Pro Val Arg Ala Glu Trp
    530                 535                 540                 
Arg Gln Met Asn Asn Ile Pro Leu Val Ser Glu Thr Asn Asn Tyr Arg
545                 550                 555                 560 
Ile Ile Lys His Gly Gln Lys Leu Leu Leu Ile Thr Ser Arg Thr Pro
                565                 570                 575     
Gln Trp Lys Lys Asn Arg Val Thr Val Tyr Glu Tyr Asp Ile Arg Gly
            580                 585                 590         
Asp Gln Trp Ile Asn Ile Gly Thr Thr Leu Gly Leu Leu Gln Phe Asp
        595                 600                 605             
Ser Asn Phe Phe Cys Leu Ser Ala Arg Val Tyr Pro Ser Cys Leu Glu
    610                 615                 620                 
Pro Gly Gln Ser Phe Leu Thr Glu Glu Glu Glu Ile Pro Ser Glu Ser
625                 630                 635                 640 
Ser Thr Glu Trp Asp Leu Gly Gly Phe Ser Glu Pro Asp Ser Glu Ser
                645                 650                 655     
Gly Ser Ser Ser Ser Leu Ser Asp Asp Asp Phe Trp Val Arg Val Ala
            660                 665                 670         
Pro Gln
        


<210> 7145
<211> 684
<212> PRT
<213> Homo sapiens

<400> 7145
Met Gln Ser Arg Glu Asp Val Pro Arg Ser Arg Arg Leu Ala Ser Pro
 1               5                  10                  15      
Arg Gly Gly Arg Arg Pro Lys Arg Ile Ser Lys Pro Ser Val Ser Ala
            20                  25                  30          
Phe Phe Thr Gly Pro Glu Glu Leu Lys Asp Thr Ala His Ser Ala Ala
        35                  40                  45              
Leu Leu Ala Gln Leu Lys Ser Phe Tyr Asp Ala Arg Leu Leu Cys Asp
    50                  55                  60                  
Val Thr Ile Glu Val Val Thr Pro Gly Ser Gly Pro Gly Thr Gly Arg
65                  70                  75                  80  
Leu Phe Ser Cys Asn Arg Asn Val Leu Ala Ala Ala Cys Pro Tyr Phe
                85                  90                  95      
Lys Ser Met Phe Thr Gly Gly Met Tyr Glu Ser Gln Gln Ala Ser Val
            100                 105                 110         
Thr Met His Asp Val Asp Ala Glu Ser Phe Glu Val Leu Val Asp Tyr
        115                 120                 125             
Cys Tyr Thr Gly Arg Val Ser Leu Ser Glu Ala Asn Val Gln Arg Leu
    130                 135                 140                 
Tyr Ala Ala Ser Asp Met Leu Gln Leu Glu Tyr Val Arg Glu Ala Cys
145                 150                 155                 160 
Ala Ser Phe Leu Ala Arg Arg Leu Asp Leu Thr Asn Cys Thr Ala Ile
                165                 170                 175     
Leu Lys Phe Ala Asp Ala Phe Asp His His Lys Leu Arg Ser Gln Ala
            180                 185                 190         
Gln Ser Tyr Ile Ala His Asn Phe Lys Gln Leu Ser Arg Met Gly Ser
        195                 200                 205             
Ile Arg Glu Glu Thr Leu Ala Asp Leu Thr Leu Ala Gln Leu Leu Ala
    210                 215                 220                 
Val Leu Arg Leu Asp Ser Leu Asp Ile Glu Ser Glu Arg Thr Val Cys
225                 230                 235                 240 
His Val Ala Val Gln Trp Leu Glu Ala Ala Ala Lys Glu Arg Gly Pro
                245                 250                 255     
Ser Ala Ala Glu Val Phe Lys Cys Val Arg Trp Met His Phe Thr Glu
            260                 265                 270         
Glu Asp Gln Asp Tyr Leu Glu Gly Leu Leu Thr Lys Pro Ile Val Lys
        275                 280                 285             
Lys Tyr Cys Leu Asp Val Ile Glu Gly Ala Leu Gln Met Arg Tyr Gly
    290                 295                 300                 
Asp Leu Leu Tyr Lys Ser Leu Val Pro Val Pro Asn Ser Ser Ser Ser
305                 310                 315                 320 
Ser Ser Ser Ser Asn Ser Leu Val Ser Ala Ala Glu Asn Pro Pro Gln
                325                 330                 335     
Arg Leu Gly Met Cys Ala Lys Glu Met Val Ile Phe Phe Gly His Pro
            340                 345                 350         
Arg Asp Pro Phe Leu Cys Tyr Asp Pro Tyr Ser Gly Asp Ile Tyr Thr
        355                 360                 365             
Met Pro Ser Pro Leu Thr Ser Phe Ala His Thr Lys Thr Val Thr Ser
    370                 375                 380                 
Ser Ala Val Cys Val Ser Pro Asp His Asp Ile Tyr Leu Ala Ala Gln
385                 390                 395                 400 
Pro Arg Lys Asp Leu Trp Val Tyr Lys Pro Ala Gln Asn Ser Trp Gln
                405                 410                 415     
Gln Leu Ala Asp Arg Leu Leu Cys Arg Glu Gly Met Asp Val Ala Tyr
            420                 425                 430         
Leu Asn Gly Tyr Ile Tyr Ile Leu Gly Gly Arg Asp Pro Ile Thr Gly
        435                 440                 445             
Val Lys Leu Lys Glu Val Glu Cys Tyr Ser Val Gln Arg Asn Gln Trp
    450                 455                 460                 
Ala Leu Val Ala Pro Val Pro His Ser Phe Tyr Ser Phe Glu Leu Ile
465                 470                 475                 480 
Val Val Gln Asn Tyr Leu Tyr Ala Val Asn Ser Lys Arg Met Leu Cys
                485                 490                 495     
Tyr Asp Pro Ser His Asn Met Trp Leu Asn Cys Ala Ser Leu Lys Arg
            500                 505                 510         
Ser Asp Phe Gln Glu Ala Cys Val Phe Asn Asp Glu Ile Tyr Cys Ile
        515                 520                 525             
Cys Asp Ile Pro Val Met Lys Val Tyr Asn Pro Ala Arg Gly Glu Trp
    530                 535                 540                 
Arg Arg Ile Ser Asn Ile Pro Leu Asp Ser Glu Thr His Asn Tyr Gln
545                 550                 555                 560 
Ile Val Asn His Asp Gln Lys Leu Leu Leu Ile Thr Ser Thr Thr Pro
                565                 570                 575     
Gln Trp Lys Lys Asn Arg Val Thr Val Tyr Glu Tyr Asp Thr Arg Glu
            580                 585                 590         
Asp Gln Trp Ile Asn Ile Gly Thr Met Leu Gly Leu Leu Gln Phe Asp
        595                 600                 605             
Ser Gly Phe Ile Cys Leu Cys Ala Arg Val Tyr Pro Ser Cys Leu Glu
    610                 615                 620                 
Pro Gly Gln Ser Phe Ile Thr Glu Glu Asp Asp Ala Arg Ser Glu Ser
625                 630                 635                 640 
Ser Thr Glu Trp Asp Leu Asp Gly Phe Ser Glu Leu Asp Ser Glu Ser
                645                 650                 655     
Gly Ser Ser Ser Ser Phe Ser Asp Asp Glu Val Trp Val Gln Val Ala
            660                 665                 670         
Pro Gln Arg Asn Ala Gln Asp Gln Gln Gly Ser Leu
        675                 680                 


<210> 7146
<211> 674
<212> PRT
<213> Homo sapiens

<400> 7146
Met Gln Ser Arg Glu Asp Ala Pro Arg Ser Arg Arg Leu Ala Ser Pro
 1               5                  10                  15      
Arg Gly Gly Lys Arg Pro Lys Lys Ile His Lys Pro Thr Val Ser Ala
            20                  25                  30          
Phe Phe Thr Gly Pro Glu Glu Leu Lys Asp Thr Ala His Ser Ala Ala
        35                  40                  45              
Leu Leu Ala Gln Leu Lys Ser Phe Tyr Asp Ala Arg Gln Leu Cys Asp
    50                  55                  60                  
Val Thr Ile Glu Val Val Thr Pro Gly Ser Gly Pro Gly Thr Gly Arg
65                  70                  75                  80  
Leu Phe Pro Cys Asn Arg Asn Val Leu Ala Ala Ala Cys Pro Tyr Phe
                85                  90                  95      
Lys Ser Met Phe Thr Gly Gly Met Tyr Glu Ser Gln Gln Ala Ser Val
            100                 105                 110         
Thr Met His Asp Val Asp Ala Glu Ser Phe Glu Val Leu Val Asp Tyr
        115                 120                 125             
Cys Tyr Thr Gly Arg Val Ser Leu Ser Glu Ala Asn Val Glu Arg Leu
    130                 135                 140                 
Tyr Ala Ala Ser Asp Met Leu Gln Leu Glu Tyr Val Arg Glu Ala Cys
145                 150                 155                 160 
Ala Ser Phe Leu Ala Arg Arg Leu Asp Leu Thr Asn Cys Thr Ala Ile
                165                 170                 175     
Leu Lys Phe Ala Asp Ala Phe Gly His Arg Lys Leu Arg Ser Gln Ala
            180                 185                 190         
Gln Ser Tyr Ile Ala Gln Asn Phe Lys Gln Leu Ser His Met Gly Ser
        195                 200                 205             
Ile Arg Glu Glu Thr Leu Ala Asp Leu Thr Leu Ala Gln Leu Leu Ala
    210                 215                 220                 
Val Leu Arg Leu Asp Ser Leu Asp Val Glu Ser Glu Gln Thr Val Cys
225                 230                 235                 240 
His Val Ala Val Gln Trp Leu Glu Ala Ala Pro Lys Glu Arg Gly Pro
                245                 250                 255     
Ser Ala Ala Glu Val Phe Lys Cys Val Arg Trp Met His Phe Thr Glu
            260                 265                 270         
Glu Asp Gln Asp Tyr Leu Glu Gly Leu Leu Thr Lys Pro Ile Val Lys
        275                 280                 285             
Lys Tyr Cys Leu Asp Val Ile Glu Gly Ala Leu Gln Met Arg Tyr Gly
    290                 295                 300                 
Asp Leu Leu Tyr Lys Ser Leu Val Pro Val Pro Asn Ser Ser Ser Ser
305                 310                 315                 320 
Ser Ser Ser Ser Asn Ser Leu Val Ser Ala Ala Glu Asn Pro Pro Gln
                325                 330                 335     
Arg Leu Gly Met Cys Ala Lys Glu Met Val Ile Phe Phe Gly His Pro
            340                 345                 350         
Arg Asp Pro Phe Leu Cys Cys Asp Pro Tyr Ser Gly Asp Leu Tyr Lys
        355                 360                 365             
Val Pro Ser Pro Leu Thr Cys Leu Ala His Thr Arg Thr Val Thr Thr
    370                 375                 380                 
Leu Ala Val Cys Ile Ser Pro Asp His Asp Ile Tyr Leu Ala Ala Gln
385                 390                 395                 400 
Pro Arg Thr Asp Leu Trp Val Tyr Lys Pro Ala Gln Asn Ser Trp Gln
                405                 410                 415     
Gln Leu Ala Asp Arg Leu Leu Cys Arg Glu Gly Met Asp Val Ala Tyr
            420                 425                 430         
Leu Asn Gly Tyr Ile Tyr Ile Leu Gly Gly Arg Asp Pro Ile Thr Gly
        435                 440                 445             
Val Lys Leu Lys Glu Val Glu Cys Tyr Asn Val Lys Arg Asn Gln Trp
    450                 455                 460                 
Ala Leu Val Ala Pro Leu Pro His Ser Phe Leu Ser Phe Asp Leu Met
465                 470                 475                 480 
Val Ile Arg Asp Tyr Leu Tyr Ala Leu Asn Ser Lys Arg Met Phe Cys
                485                 490                 495     
Tyr Asp Pro Ser His Asn Met Trp Leu Lys Cys Val Ser Leu Lys Arg
            500                 505                 510         
Asn Asp Phe Gln Glu Ala Cys Val Phe Asn Glu Glu Ile Tyr Cys Ile
        515                 520                 525             
Cys Asp Ile Pro Val Met Lys Val Tyr Asn Pro Val Arg Ala Glu Trp
    530                 535                 540                 
Arg Gln Met Asn Asn Ile Pro Leu Val Ser Glu Thr Asn Asn Tyr Arg
545                 550                 555                 560 
Ile Ile Lys His Gly Gln Lys Leu Leu Leu Ile Thr Ser Arg Thr Pro
                565                 570                 575     
Gln Trp Lys Lys Asn Arg Val Thr Val Tyr Glu Tyr Asp Ile Arg Gly
            580                 585                 590         
Asp Gln Trp Ile Asn Ile Gly Thr Thr Leu Gly Leu Leu Gln Phe Asp
        595                 600                 605             
Ser Asn Phe Phe Cys Leu Ser Ala Arg Val Tyr Pro Ser Cys Leu Glu
    610                 615                 620                 
Pro Gly Gln Ser Phe Leu Thr Glu Glu Glu Glu Ile Pro Ser Glu Ser
625                 630                 635                 640 
Ser Thr Glu Trp Asp Leu Gly Gly Phe Ser Glu Pro Asp Ser Glu Ser
                645                 650                 655     
Gly Ser Ser Ser Ser Leu Ser Asp Asp Asp Phe Trp Val Arg Val Ala
            660                 665                 670         
Pro Gln
        


<210> 7147
<211> 620
<212> PRT
<213> Homo sapiens

<400> 7147
Met Pro Ser Glu Arg Cys Leu Ser Ile Gln Glu Met Leu Thr Gly Gln
 1               5                  10                  15      
Arg Leu Cys His Ser Glu Ser His Asn Asp Ser Val Leu Ala Ala Leu
            20                  25                  30          
Asn Gln Gln Arg Ser Asp Gly Ile Leu Cys Asp Ile Thr Leu Ile Ala
        35                  40                  45              
Glu Glu Gln Lys Phe His Ala His Lys Ala Val Leu Ala Ala Cys Ser
    50                  55                  60                  
Asp Tyr Phe Arg Ala Met Phe Ser Leu Cys Met Val Glu Ser Gly Ala
65                  70                  75                  80  
Asp Glu Val Asn Leu His Gly Val Thr Ser Leu Gly Leu Lys Gln Ala
                85                  90                  95      
Leu Glu Phe Ala Tyr Thr Gly Gln Ile Leu Leu Glu Pro Gly Val Ile
            100                 105                 110         
Gln Asp Val Leu Ala Ala Gly Ser His Leu Gln Leu Leu Glu Leu Leu
        115                 120                 125             
Asn Leu Cys Ser His Tyr Leu Ile Gln Glu Leu Asn Ser Phe Asn Tyr
    130                 135                 140                 
Leu Asp Leu Tyr Arg Leu Ala Asp Leu Phe Asn Leu Thr Leu Leu Glu
145                 150                 155                 160 
Lys Ala Val Ile Asp Phe Leu Val Lys His Leu Ser Glu Leu Leu Lys
                165                 170                 175     
Ser Arg Pro Glu Glu Val Leu Thr Leu Pro Tyr Cys Leu Leu Gln Glu
            180                 185                 190         
Val Leu Lys Ser Asp Arg Leu Thr Ser Leu Ser Glu Glu Gln Ile Trp
        195                 200                 205             
Gln Leu Ala Val Arg Trp Leu Glu His Asn Cys His Tyr Gln Tyr Met
    210                 215                 220                 
Asp Glu Leu Leu Gln Tyr Ile Arg Phe Gly Leu Met Asp Val Asp Thr
225                 230                 235                 240 
Leu His Thr Val Ala Leu Ser His Pro Leu Val Gln Ala Ser Glu Thr
                245                 250                 255     
Ala Thr Ala Leu Val Asn Glu Ala Leu Glu Tyr His Gln Ser Ile Tyr
            260                 265                 270         
Ala Gln Pro Val Trp Gln Thr Arg Arg Thr Lys Pro Arg Phe Gln Ser
        275                 280                 285             
Asp Thr Leu Tyr Ile Ile Gly Gly Lys Lys Arg Glu Val Cys Lys Val
    290                 295                 300                 
Lys Glu Leu Arg Tyr Phe Asn Pro Val Asp Gln Glu Asn Ala Leu Ile
305                 310                 315                 320 
Ala Ala Ile Ala Asn Trp Ser Glu Leu Ala Ser Met Pro Val Gly Arg
                325                 330                 335     
Ser His His Cys Val Ala Val Met Gly Asp Phe Leu Phe Val Ala Gly
            340                 345                 350         
Gly Glu Val Glu His Ala Ser Gly Arg Thr Cys Ala Val Arg Thr Ala
        355                 360                 365             
Cys Arg Tyr Asp Pro Arg Ser Asn Ser Trp Ala Glu Ile Ala Pro Met
    370                 375                 380                 
Lys Asn Cys Arg Glu His Phe Val Leu Gly Ala Met Glu Glu Tyr Leu
385                 390                 395                 400 
Tyr Ala Val Gly Gly Arg Asn Glu Leu Arg Gln Val Leu Pro Thr Val
                405                 410                 415     
Glu Arg Tyr Cys Pro Lys Lys Asn Lys Trp Thr Phe Val Gln Ser Phe
            420                 425                 430         
Asp Arg Ser Leu Ser Cys His Ala Gly Tyr Val Ala Asp Gly Leu Leu
        435                 440                 445             
Trp Ile Ser Gly Gly Val Thr Asn Thr Ala Gln Tyr Gln Asn Arg Leu
    450                 455                 460                 
Met Val Tyr Glu Pro Asn Gln Asn Lys Trp Ile Ser Arg Ser Pro Met
465                 470                 475                 480 
Leu Gln Arg Arg Val Tyr His Ser Met Ala Ala Val Gln Arg Lys Leu
                485                 490                 495     
Tyr Val Leu Gly Gly Asn Asp Leu Asp Tyr Asn Asn Asp Arg Ile Leu
            500                 505                 510         
Val Arg His Ile Asp Ser Tyr Asn Ile Asp Thr Asp Gln Trp Thr Arg
        515                 520                 525             
Cys Asn Phe Asn Leu Leu Thr Gly Gln Asn Glu Ser Gly Val Ala Val
    530                 535                 540                 
His Asn Gly Arg Ile Tyr Leu Val Gly Gly Tyr Ser Ile Trp Thr Asn
545                 550                 555                 560 
Glu Pro Leu Ala Cys Ile Gln Val Leu Asp Val Ser Arg Glu Gly Lys
                565                 570                 575     
Glu Glu Val Phe Tyr Gly Pro Thr Leu Pro Phe Ala Ser Asn Gly Ile
            580                 585                 590         
Ala Ala Cys Phe Leu Pro Ala Pro Tyr Phe Thr Cys Pro Asn Leu Gln
        595                 600                 605             
Thr Leu Gln Val Pro His His Arg Ile Gly Thr Ile
    610                 615                 620 


<210> 7148
<211> 619
<212> PRT
<213> Homo sapiens

<400> 7148
Met Tyr Gly Phe Val Asn His Ala Leu Glu Leu Leu Val Ile Arg Asn
 1               5                  10                  15      
Tyr Gly Pro Glu Val Trp Glu Asp Ile Lys Lys Glu Ala Gln Leu Asp
            20                  25                  30          
Glu Glu Gly Gln Phe Leu Val Arg Ile Ile Tyr Asp Asp Ser Lys Thr
        35                  40                  45              
Tyr Asp Leu Val Ala Ala Ala Ser Lys Val Leu Asn Leu Asn Ala Gly
    50                  55                  60                  
Glu Ile Leu Gln Met Phe Gly Lys Met Phe Phe Val Phe Cys Gln Glu
65                  70                  75                  80  
Ser Gly Tyr Asp Thr Ile Leu Arg Val Leu Gly Ser Asn Val Arg Glu
                85                  90                  95      
Phe Leu Gln Asn Leu Asp Ala Leu His Asp His Leu Ala Thr Ile Tyr
            100                 105                 110         
Pro Gly Met Arg Ala Pro Ser Phe Arg Cys Thr Asp Ala Glu Lys Gly
        115                 120                 125             
Lys Gly Leu Ile Leu His Tyr Tyr Ser Glu Arg Glu Gly Leu Gln Asp
    130                 135                 140                 
Ile Val Ile Gly Ile Ile Lys Thr Val Ala Gln Gln Ile His Gly Thr
145                 150                 155                 160 
Glu Ile Asp Met Lys Val Ile Gln Gln Arg Asn Glu Glu Cys Asp His
                165                 170                 175     
Thr Gln Phe Leu Ile Glu Glu Lys Glu Ser Lys Glu Glu Asp Phe Tyr
            180                 185                 190         
Glu Asp Leu Asp Arg Phe Glu Glu Asn Gly Thr Gln Glu Ser Arg Ile
        195                 200                 205             
Ser Pro Tyr Thr Phe Cys Lys Ala Phe Pro Phe His Ile Ile Phe Asp
    210                 215                 220                 
Arg Asp Leu Val Val Thr Gln Cys Gly Asn Ala Ile Tyr Arg Val Leu
225                 230                 235                 240 
Pro Gln Leu Gln Pro Gly Asn Cys Ser Leu Leu Ser Val Phe Ser Leu
                245                 250                 255     
Val Arg Pro His Ile Asp Ile Ser Phe His Gly Ile Leu Ser His Ile
            260                 265                 270         
Asn Thr Val Phe Val Leu Arg Ser Lys Glu Gly Leu Leu Asp Val Glu
        275                 280                 285             
Lys Leu Glu Cys Glu Asp Glu Leu Thr Gly Thr Glu Ile Ser Cys Leu
    290                 295                 300                 
Arg Leu Lys Gly Gln Met Ile Tyr Leu Pro Glu Ala Asp Ser Ile Leu
305                 310                 315                 320 
Phe Leu Cys Ser Pro Ser Val Met Asn Leu Asp Asp Leu Thr Arg Arg
                325                 330                 335     
Gly Leu Tyr Leu Ser Asp Ile Pro Leu His Asp Ala Thr Arg Asp Leu
            340                 345                 350         
Val Leu Leu Gly Glu Gln Phe Arg Glu Glu Tyr Lys Leu Thr Gln Glu
        355                 360                 365             
Leu Glu Ile Leu Thr Asp Arg Leu Gln Leu Thr Leu Arg Ala Leu Glu
    370                 375                 380                 
Asp Glu Lys Lys Lys Thr Asp Thr Leu Leu Tyr Ser Val Leu Pro Pro
385                 390                 395                 400 
Ser Val Ala Asn Glu Leu Arg His Lys Arg Pro Val Pro Ala Lys Arg
                405                 410                 415     
Tyr Asp Asn Val Thr Ile Leu Phe Ser Gly Ile Val Gly Phe Asn Ala
            420                 425                 430         
Phe Cys Ser Lys His Ala Ser Gly Glu Gly Ala Met Lys Ile Val Asn
        435                 440                 445             
Leu Leu Asn Asp Leu Tyr Thr Arg Phe Asp Thr Leu Thr Asp Ser Arg
    450                 455                 460                 
Lys Asn Pro Phe Val Tyr Lys Val Glu Thr Val Gly Asp Lys Tyr Met
465                 470                 475                 480 
Thr Val Ser Gly Leu Pro Glu Pro Cys Ile His His Ala Arg Ser Ile
                485                 490                 495     
Cys His Leu Ala Leu Asp Met Met Glu Ile Ala Gly Gln Val Gln Val
            500                 505                 510         
Asp Gly Glu Ser Val Gln Ile Thr Ile Gly Ile His Thr Gly Glu Val
        515                 520                 525             
Val Thr Gly Val Ile Gly Gln Arg Met Pro Arg Tyr Cys Leu Phe Gly
    530                 535                 540                 
Asn Thr Val Asn Leu Thr Ser Arg Thr Glu Thr Thr Gly Glu Lys Gly
545                 550                 555                 560 
Lys Ile Asn Val Ser Glu Tyr Thr Tyr Arg Cys Leu Met Ser Pro Glu
                565                 570                 575     
Asn Ser Asp Pro Gln Phe His Leu Glu His Arg Gly Pro Val Ser Met
            580                 585                 590         
Lys Gly Lys Lys Glu Pro Met Gln Val Trp Phe Leu Ser Arg Lys Asn
        595                 600                 605             
Thr Gly Thr Glu Glu Thr Lys Gln Asp Asp Asp
    610                 615                 


<210> 7149
<211> 2080
<212> PRT
<213> Homo sapiens

<400> 7149
Met Gly Ser Gly Ala Ile Cys Trp Phe Asn Leu Arg Asp Val Gly Ser
 1               5                  10                  15      
Gln Ala Pro Glu Asp Arg Trp Tyr Glu Ala Glu Lys Val Trp Leu Ala
            20                  25                  30          
Gln Lys Asp Gly Phe Thr Leu Ala Thr Val Leu Lys Pro Asp Glu Gly
        35                  40                  45              
Thr Ala Asp Leu Pro Ala Gly Arg Val Arg Leu Trp Ile Asp Ala Asp
    50                  55                  60                  
Lys Thr Ile Thr Glu Val Asp Glu Glu His Val His Arg Ala Asn Pro
65                  70                  75                  80  
Pro Glu Leu Asp Gln Val Glu Asp Leu Ala Ser Leu Ile Ser Val Asn
                85                  90                  95      
Glu Ser Ser Val Leu Asn Thr Leu Leu Gln Arg Tyr Lys Ala Gln Leu
            100                 105                 110         
Leu His Thr Cys Thr Gly Pro Asp Leu Ile Val Leu Gln Pro Arg Gly
        115                 120                 125             
Pro Ser Val Pro Ser Ala Gly Lys Val Pro Lys Gly Arg Arg Asp Gly
    130                 135                 140                 
Leu Pro Ala His Ile Gly Ser Met Ala Gln Arg Ala Tyr Trp Ala Leu
145                 150                 155                 160 
Leu Asn Gln Arg Arg Asp Gln Ser Ile Val Ala Leu Gly Arg Ser Gly
                165                 170                 175     
Ala Gly Lys Thr Thr Cys Cys Glu Gln Val Leu Glu His Leu Val Gly
            180                 185                 190         
Met Ala Gly Ser Val Asp Gly Arg Val Ser Val Glu Lys Ile Arg Ala
        195                 200                 205             
Thr Phe Thr Val Leu Arg Ala Phe Gly Ser Val Ser Met Ala His Ser
    210                 215                 220                 
Arg Ser Ala Thr Arg Phe Ser Met Val Met Ser Leu Asp Phe Asn Ala
225                 230                 235                 240 
Thr Gly Arg Ile Thr Ala Ala Gln Leu Gln Thr Met Leu Leu Glu Lys
                245                 250                 255     
Ser Arg Val Ala Arg Gln Pro Glu Gly Glu Ser Asn Phe Leu Val Phe
            260                 265                 270         
Ser Gln Met Leu Ala Gly Leu Asp Leu Asp Leu Arg Thr Glu Leu Asn
        275                 280                 285             
Leu His Gln Met Ala Asp Ser Ser Ser Phe Gly Met Gly Val Trp Ser
    290                 295                 300                 
Lys Pro Glu Asp Lys Gln Lys Ala Ala Ala Ala Phe Ala Gln Leu Gln
305                 310                 315                 320 
Gly Ala Met Glu Met Leu Gly Ile Ser Glu Ser Glu Gln Arg Ala Val
                325                 330                 335     
Trp Arg Val Leu Ala Ala Ile Tyr His Leu Gly Ala Ala Gly Ala Cys
            340                 345                 350         
Lys Val Gly Arg Lys Gln Phe Met Arg Phe Glu Trp Ala Asn Tyr Ala
        355                 360                 365             
Ala Glu Ala Leu Gly Cys Glu Tyr Glu Glu Leu Asn Thr Ala Thr Phe
    370                 375                 380                 
Lys His His Leu Arg Gln Ile Ile Gln Gln Met Thr Phe Gly Pro Ser
385                 390                 395                 400 
Arg Trp Gly Leu Glu Asp Glu Glu Thr Ser Ser Gly Leu Lys Met Thr
                405                 410                 415     
Gly Val Asp Cys Val Glu Gly Met Ala Ser Gly Leu Tyr Gln Glu Leu
            420                 425                 430         
Phe Ala Ala Val Val Ser Leu Ile Asn Arg Ser Phe Ser Ser His His
        435                 440                 445             
Leu Ser Met Ala Ser Ile Met Val Val Asp Ser Pro Gly Phe Gln Asn
    450                 455                 460                 
Pro Arg His Gln Gly Lys Asp Arg Ala Ala Thr Phe Glu Glu Leu Cys
465                 470                 475                 480 
His Asn Tyr Ala His Glu Arg Leu Gln Leu Leu Phe Tyr Gln Arg Thr
                485                 490                 495     
Phe Val Ser Thr Leu Gln Arg Tyr Gln Glu Glu Gly Val Pro Val Gln
            500                 505                 510         
Phe Asp Leu Pro Asp Pro Ser Pro Gly Thr Thr Val Ala Val Val Asp
        515                 520                 525             
Gln Asn Pro Ser Gln Val Arg Leu Pro Ala Gly Gly Gly Ala Gln Asp
    530                 535                 540                 
Ala Arg Gly Leu Phe Trp Val Leu Asp Glu Glu Val His Val Glu Gly
545                 550                 555                 560 
Ser Ser Asp Ser Val Val Leu Glu Arg Leu Cys Ala Ala Phe Glu Lys
                565                 570                 575     
Lys Gly Ala Gly Thr Glu Gly Ser Ser Ala Leu Arg Thr Cys Glu Gln
            580                 585                 590         
Pro Leu Gln Cys Glu Ile Phe His Gln Leu Gly Trp Asp Pro Val Arg
        595                 600                 605             
Tyr Asp Leu Thr Gly Trp Leu His Arg Ala Lys Pro Asn Leu Ser Ala
    610                 615                 620                 
Leu Asp Ala Pro Gln Val Leu His Gln Ser Lys Arg Glu Glu Leu Arg
625                 630                 635                 640 
Ser Leu Phe Gln Ala Arg Ala Lys Leu Pro Pro Val Cys Arg Ala Val
                645                 650                 655     
Ala Gly Leu Glu Gly Thr Ser Gln Gln Ala Leu Gln Arg Ser Arg Met
            660                 665                 670         
Val Arg Arg Thr Phe Ala Ser Ser Leu Ala Ala Val Arg Arg Lys Ala
        675                 680                 685             
Pro Cys Ser Gln Ile Lys Leu Gln Met Asp Ala Leu Thr Ser Met Ile
    690                 695                 700                 
Lys Arg Ser Arg Leu His Phe Ile His Cys Leu Val Pro Asn Pro Val
705                 710                 715                 720 
Val Glu Ser Arg Ser Gly Gln Glu Ser Pro Pro Pro Pro Gln Pro Gly
                725                 730                 735     
Arg Asp Lys Pro Gly Ala Gly Gly Pro Leu Ala Leu Asp Ile Pro Ala
            740                 745                 750         
Leu Arg Val Gln Leu Ala Gly Phe His Ile Leu Glu Ala Leu Arg Leu
        755                 760                 765             
His Arg Thr Gly Tyr Ala Asp His Met Gly Leu Thr Arg Phe Arg Arg
    770                 775                 780                 
Gln Phe Gln Val Leu Asp Ala Pro Leu Leu Lys Lys Leu Met Ser Thr
785                 790                 795                 800 
Ser Glu Gly Ile Asp Glu Arg Lys Ala Val Glu Glu Leu Leu Glu Thr
                805                 810                 815     
Leu Asp Leu Glu Lys Lys Ala Val Ala Val Gly His Ser Gln Val Phe
            820                 825                 830         
Leu Lys Ala Gly Val Ile Ser Arg Leu Glu Lys Gln Arg Glu Lys Leu
        835                 840                 845             
Val Ser Gln Ser Ile Val Leu Phe Gln Ala Ala Cys Lys Gly Phe Leu
    850                 855                 860                 
Ser Arg Gln Glu Phe Lys Lys Leu Lys Ile Arg Arg Leu Ala Ala Gln
865                 870                 875                 880 
Cys Ile Gln Lys Asn Val Ala Val Phe Leu Ala Val Lys Asp Trp Pro
                885                 890                 895     
Trp Trp Gln Leu Leu Gly Ser Leu Gln Pro Leu Leu Ser Ala Thr Ile
            900                 905                 910         
Gly Thr Glu Gln Leu Arg Ala Lys Glu Glu Glu Leu Thr Thr Leu Arg
        915                 920                 925             
Arg Lys Leu Glu Lys Ser Glu Lys Leu Arg Asn Glu Leu Arg Gln Asn
    930                 935                 940                 
Thr Asp Leu Leu Glu Ser Lys Ile Ala Asp Leu Thr Ser Asp Leu Ala
945                 950                 955                 960 
Asp Glu Arg Phe Lys Gly Asp Val Ala Cys Gln Val Leu Glu Ser Glu
                965                 970                 975     
Arg Ala Glu Arg Leu Gln Ala Phe Arg Glu Val Gln Glu Leu Lys Ser
            980                 985                 990         
Lys His Glu Gln Val Gln Lys Lys Leu Gly Asp Val Asn Lys Gln Leu
        995                 1000                1005            
Glu Glu Ala Gln Gln Lys Ile Gln Leu Asn Asp Leu Glu Arg Asn Pro
    1010                1015                1020                
Thr Gly Gly Ala Asp Glu Trp Gln Met Arg Phe Asp Cys Ala Gln Met
1025                1030                1035                1040
Glu Asn Glu Phe Leu Arg Lys Arg Leu Gln Gln Cys Glu Glu Arg Leu
                1045                1050                1055    
Asp Ser Glu Leu Thr Ala Arg Lys Glu Leu Glu Gln Lys Leu Gly Glu
            1060                1065                1070        
Leu Gln Ser Ala Tyr Asp Gly Ala Lys Lys Met Ala His Gln Leu Lys
        1075                1080                1085            
Arg Lys Cys His His Leu Thr Cys Asp Leu Glu Asp Thr Cys Val Leu
    1090                1095                1100                
Leu Glu Asn Gln Gln Ser Arg Asn His Glu Leu Glu Lys Lys Gln Lys
1105                1110                1115                1120
Lys Phe Asp Leu Gln Leu Ala Gln Ala Leu Gly Glu Ser Val Phe Glu
                1125                1130                1135    
Lys Gly Leu Arg Glu Lys Val Thr Gln Glu Asn Thr Ser Val Arg Trp
            1140                1145                1150        
Glu Leu Gly Gln Leu Gln Gln Gln Leu Lys Gln Lys Glu Gln Glu Ala
        1155                1160                1165            
Ser Gln Leu Lys Gln Gln Val Glu Met Leu Gln Asp His Lys Arg Glu
    1170                1175                1180                
Leu Leu Gly Ser Pro Ser Leu Gly Glu Asn Cys Val Ala Gly Leu Lys
1185                1190                1195                1200
Glu Arg Leu Trp Lys Leu Glu Ser Ser Ala Leu Glu Gln Gln Lys Ile
                1205                1210                1215    
Gln Ser Gln Gln Glu Asn Thr Ile Lys Gln Leu Glu Gln Leu Arg Gln
            1220                1225                1230        
Arg Phe Glu Leu Glu Ile Glu Arg Met Lys Gln Met His Gln Lys Asp
        1235                1240                1245            
Arg Glu Asp Gln Glu Glu Glu Leu Glu Asp Val Arg Gln Ser Cys Gln
    1250                1255                1260                
Lys Arg Leu His Gln Leu Glu Met Gln Leu Glu Gln Glu Tyr Glu Glu
1265                1270                1275                1280
Lys Gln Met Val Leu His Glu Lys Gln Asp Leu Glu Gly Leu Ile Gly
                1285                1290                1295    
Thr Leu Cys Asp Gln Ile Gly His Arg Asp Phe Asp Val Glu Lys Arg
            1300                1305                1310        
Leu Arg Arg Asp Leu Arg Arg Thr His Ala Leu Leu Ser Asp Val Gln
        1315                1320                1325            
Leu Leu Leu Gly Thr Met Glu Asp Gly Lys Thr Ser Val Ser Lys Glu
    1330                1335                1340                
Glu Leu Glu Lys Val His Ser Gln Leu Glu Gln Ser Glu Ala Lys Cys
1345                1350                1355                1360
Glu Glu Ala Leu Lys Thr Gln Lys Val Leu Thr Ala Asp Leu Glu Ser
                1365                1370                1375    
Met His Ser Glu Leu Glu Asn Met Thr Arg Asn Lys Ser Leu Val Asp
            1380                1385                1390        
Glu Gln Leu Tyr Arg Leu Gln Phe Glu Lys Ala Asp Leu Leu Lys Arg
        1395                1400                1405            
Ile Asp Glu Asp Gln Asp Asp Leu Asn Glu Leu Met Gln Lys His Lys
    1410                1415                1420                
Asp Leu Ile Ala Gln Ser Ala Ala Asp Ile Gly Gln Ile Gln Glu Leu
1425                1430                1435                1440
Gln Leu Gln Leu Glu Glu Ala Lys Lys Glu Lys His Lys Leu Gln Glu
                1445                1450                1455    
Gln Leu Gln Val Ala Gln Met Arg Ile Glu Tyr Leu Glu Gln Ser Thr
            1460                1465                1470        
Val Asp Arg Ala Ile Val Ser Arg Gln Glu Ala Val Ile Cys Asp Leu
        1475                1480                1485            
Glu Asn Lys Thr Glu Phe Gln Lys Val Gln Ile Lys Arg Phe Glu Val
    1490                1495                1500                
Leu Val Ile Arg Leu Arg Asp Ser Leu Ile Lys Met Gly Glu Glu Leu
1505                1510                1515                1520
Ser Gln Ala Ala Thr Ser Glu Ser Gln Gln Arg Glu Ser Ser Gln Tyr
                1525                1530                1535    
Tyr Gln Arg Arg Leu Glu Glu Leu Lys Ala Asp Met Glu Glu Leu Val
            1540                1545                1550        
Gln Arg Glu Ala Glu Ala Ser Arg Arg Cys Met Glu Leu Glu Lys Tyr
        1555                1560                1565            
Val Glu Glu Leu Ala Ala Val Arg Gln Thr Leu Gln Thr Asp Leu Glu
    1570                1575                1580                
Thr Ser Ile Arg Arg Ile Ala Asp Leu Gln Ala Ala Leu Glu Glu Val
1585                1590                1595                1600
Ala Ser Ser Asp Ser Asp Thr Glu Ser Val Gln Thr Ala Val Asp Cys
                1605                1610                1615    
Gly Ser Ser Gly Arg Lys Glu Met Asp Asn Val Ser Ile Leu Ser Ser
            1620                1625                1630        
Gln Pro Glu Gly Ser Leu Gln Ser Trp Leu Ser Cys Thr Leu Ser Leu
        1635                1640                1645            
Ala Thr Asp Thr Met Arg Thr Pro Ser Arg Gln Ser Ala Thr Ser Ser
    1650                1655                1660                
Arg Ile Leu Ser Pro Arg Ile Asn Glu Glu Ala Gly Asp Thr Glu Arg
1665                1670                1675                1680
Thr Gln Ser Ala Leu Ala Leu Ser Arg Ala Arg Ser Thr Asn Val His
                1685                1690                1695    
Ser Lys Thr Ser Gly Asp Lys Pro Val Ser Pro His Phe Val Arg Arg
            1700                1705                1710        
Gln Lys Tyr Cys His Phe Gly Asp Gly Glu Val Leu Ala Val Gln Arg
        1715                1720                1725            
Lys Ser Thr Glu Arg Leu Glu Pro Ala Ser Ser Pro Leu Ala Ser Arg
    1730                1735                1740                
Ser Thr Asn Thr Ser Pro Leu Ser Arg Glu Lys Leu Pro Ser Pro Ser
1745                1750                1755                1760
Ala Ala Leu Ser Glu Phe Val Glu Gly Leu Arg Arg Lys Arg Ala Gln
                1765                1770                1775    
Arg Gly Gln Gly Ser Thr Leu Gly Leu Glu Asp Trp Pro Thr Leu Pro
            1780                1785                1790        
Ile Tyr Gln Thr Thr Gly Ala Ser Thr Leu Arg Arg Gly Arg Ala Gly
        1795                1800                1805            
Ser Asp Glu Gly Asn Leu Ser Leu Arg Val Gly Ala Lys Ser Pro Leu
    1810                1815                1820                
Glu Ile Glu Gly Ala Ala Gly Gly Leu Leu Arg Ser Thr Ser Leu Lys
1825                1830                1835                1840
Cys Ile Ser Ser Asp Gly Val Gly Gly Thr Thr Leu Leu Pro Glu Lys
                1845                1850                1855    
Ser Lys Thr Gln Phe Ser Ser Cys Glu Ser Leu Leu Glu Ser Arg Pro
            1860                1865                1870        
Ser Met Gly Arg Lys Leu Ser Ser Pro Thr Thr Pro Arg Asp Met Leu
        1875                1880                1885            
Leu Ser Pro Thr Leu Arg Pro Arg Arg Arg Cys Leu Glu Ser Ser Val
    1890                1895                1900                
Asp Asp Ala Gly Cys Pro Asp Leu Gly Lys Glu Pro Leu Val Phe Gln
1905                1910                1915                1920
Asn Arg Gln Phe Ala His Leu Met Glu Glu Pro Leu Gly Ser Asp Pro
                1925                1930                1935    
Phe Ser Trp Lys Leu Pro Ser Leu Asp Tyr Glu Arg Lys Thr Lys Val
            1940                1945                1950        
Asp Phe Asp Asp Phe Leu Pro Ala Ile Arg Lys Pro Gln Thr Pro Thr
        1955                1960                1965            
Ser Leu Ala Gly Ser Ala Lys Gly Gly Gln Asp Gly Ser Gln Arg Ser
    1970                1975                1980                
Ser Ile His Phe Glu Thr Glu Glu Ala Asn Arg Ser Phe Leu Ser Gly
1985                1990                1995                2000
Ile Lys Thr Ile Leu Lys Lys Ser Pro Glu Pro Lys Glu Asp Pro Ala
                2005                2010                2015    
His Leu Ser Asp Ser Ser Ser Ser Ser Gly Ser Ile Val Ser Phe Lys
            2020                2025                2030        
Ser Ala Asp Ser Ile Lys Ser Arg Pro Gly Ile Pro Arg Leu Ala Gly
        2035                2040                2045            
Asp Gly Gly Glu Arg Thr Ser Pro Glu Arg Arg Glu Pro Gly Thr Gly
    2050                2055                2060                
Arg Lys Asp Asp Asp Val Ala Ser Ile Met Lys Lys Tyr Leu Gln Lys
2065                2070                2075                2080


<210> 7150
<211> 2567
<212> PRT
<213> Homo sapiens

<400> 7150
Met Ala Ile Ser Ser Arg Leu Ala Leu Trp Glu Gln Lys Ile Arg Glu
 1               5                  10                  15      
Glu Asp Lys Ser Pro Pro Pro Ser Ser Pro Pro Pro Leu Phe Ser Val
            20                  25                  30          
Ile Pro Gly Gly Phe Ile Lys Gln Leu Val Arg Gly Thr Glu Lys Glu
        35                  40                  45              
Ala Lys Glu Ala Arg Gln Arg Lys Gln Leu Ala Val Ala Ser Pro Glu
    50                  55                  60                  
Arg Glu Ile Pro Glu Ile Ser Ile Ser Gln Pro Asn Ser Lys Ser Ser
65                  70                  75                  80  
Ser Gly Thr Arg Ser Gly Ser Gln Gln Ile Ser Gln Asp Asp Gln Ser
                85                  90                  95      
Ser Ser Pro Gly Ser Ser Asp Ile Leu Gly Lys Glu Ser Glu Gly Ser
            100                 105                 110         
Arg Ser Pro Asp Pro Glu Gln Met Thr Ser Ile Asn Gly Glu Lys Ala
        115                 120                 125             
Gln Glu Leu Gly Ser Ser Ala Thr Pro Thr Lys Lys Thr Val Pro Phe
    130                 135                 140                 
Lys Arg Gly Val Arg Arg Gly Asp Val Leu Leu Met Val Ala Lys Leu
145                 150                 155                 160 
Asp Pro Asp Ser Ala Lys Pro Glu Lys Thr His Pro His Asp Ala Pro
                165                 170                 175     
Pro Cys Lys Thr Ser Pro Pro Ala Thr Asp Thr Gly Lys Glu Lys Lys
            180                 185                 190         
Gly Glu Thr Ser Arg Thr Pro Cys Gly Ser Gln Ala Ser Thr Glu Ile
        195                 200                 205             
Leu Ala Pro Lys Ala Glu Lys Thr Arg Thr Gly Gly Leu Gly Asp Pro
    210                 215                 220                 
Gly Gln Gly Thr Val Ala Leu Lys Lys Gly Glu Glu Gly Gln Ser Ile
225                 230                 235                 240 
Val Gly Lys Gly Leu Gly Thr Pro Lys Thr Thr Glu Leu Lys Glu Ala
                245                 250                 255     
Glu Pro Gln Gly Lys Asp Arg Gln Gly Thr Arg Pro Gln Ala Gln Gly
            260                 265                 270         
Pro Gly Glu Gly Val Arg Pro Gly Lys Ala Glu Lys Glu Gly Ala Glu
        275                 280                 285             
Pro Thr Asn Thr Val Glu Lys Gly Asn Val Ser Lys Asp Val Gly Ser
    290                 295                 300                 
Glu Gly Lys His Val Arg Pro Gln Ile Pro Gly Arg Lys Trp Gly Gly
305                 310                 315                 320 
Phe Leu Gly Arg Arg Ser Lys Trp Asp Gly Pro Gln Asn Lys Lys Asp
                325                 330                 335     
Lys Glu Gly Val Leu Leu Ser Lys Ala Glu Lys Thr Gly Glu Pro Gln
            340                 345                 350         
Thr Gln Met Glu Lys Thr Ser Gln Val Gln Gly Glu Leu Gly Asp Asp
        355                 360                 365             
Leu Arg Met Gly Glu Lys Ala Gly Glu Leu Arg Ser Thr Thr Gly Lys
    370                 375                 380                 
Ala Gly Glu Ser Trp Asp Lys Lys Glu Lys Met Gly Gln Pro Gln Gly
385                 390                 395                 400 
Lys Ser Gly Asn Ala Gly Glu Ala Arg Ser Gln Thr Glu Lys Gly Cys
                405                 410                 415     
Glu Ala Pro Lys Glu Val Ser Thr Met Val Glu Ser Pro Ala Ala Pro
            420                 425                 430         
Gly Lys Gly Gly Trp Pro Gly Ser Arg Gly Gln Glu Ala Glu Glu Pro
        435                 440                 445             
Cys Ser Arg Ala Gly Asp Gly Ala Gly Ala Leu Glu Thr Glu Leu Glu
    450                 455                 460                 
Gly Pro Ser Gln Pro Ala Leu Glu Lys Asp Ala Glu Arg Pro Arg Ile
465                 470                 475                 480 
Arg Lys Glu Asn Gln Asp Gly Pro Ala Pro Gln Glu Glu Gly Lys Gly
                485                 490                 495     
Gly Gln Ser Arg Asp Ser Asp Gln Ala Pro Glu Asp Arg Trp Tyr Glu
            500                 505                 510         
Ala Glu Lys Val Trp Leu Ala Gln Lys Asp Gly Phe Thr Leu Ala Thr
        515                 520                 525             
Val Leu Lys Pro Asp Glu Gly Thr Ala Asp Leu Pro Ala Gly Arg Val
    530                 535                 540                 
Arg Leu Trp Ile Asp Ala Asp Lys Thr Ile Thr Glu Val Asp Glu Glu
545                 550                 555                 560 
His Val His Arg Ala Asn Pro Pro Glu Leu Asp Gln Val Glu Asp Leu
                565                 570                 575     
Ala Ser Leu Ile Ser Val Asn Glu Ser Ser Val Leu Asn Thr Leu Leu
            580                 585                 590         
Gln Arg Tyr Lys Ala Gln Leu Leu His Thr Cys Thr Gly Pro Asp Leu
        595                 600                 605             
Ile Val Leu Gln Pro Arg Gly Pro Ser Val Pro Ser Ala Gly Lys Val
    610                 615                 620                 
Pro Lys Gly Arg Arg Asp Gly Leu Pro Ala His Ile Gly Ser Met Ala
625                 630                 635                 640 
Gln Arg Ala Tyr Trp Ala Leu Leu Asn Gln Arg Arg Asp Gln Ser Ile
                645                 650                 655     
Val Ala Leu Gly Arg Ser Gly Ala Gly Lys Thr Thr Cys Cys Glu Gln
            660                 665                 670         
Val Leu Glu His Leu Val Gly Met Ala Gly Ser Val Asp Gly Arg Val
        675                 680                 685             
Ser Val Glu Lys Ile Arg Ala Thr Phe Thr Val Leu Arg Ala Phe Gly
    690                 695                 700                 
Ser Val Ser Met Ala His Ser Arg Ser Ala Thr Arg Phe Ser Met Val
705                 710                 715                 720 
Met Ser Leu Asp Phe Asn Ala Thr Gly Arg Ile Thr Ala Ala Gln Leu
                725                 730                 735     
Gln Thr Met Leu Leu Glu Lys Ser Arg Val Ala Arg Gln Pro Glu Gly
            740                 745                 750         
Glu Ser Asn Phe Leu Val Phe Ser Gln Met Leu Ala Gly Leu Asp Leu
        755                 760                 765             
Asp Leu Arg Thr Glu Leu Asn Leu His Gln Met Ala Asp Ser Ser Ser
    770                 775                 780                 
Phe Gly Met Gly Val Trp Ser Lys Pro Glu Asp Lys Gln Lys Ala Ala
785                 790                 795                 800 
Ala Ala Phe Ala Gln Leu Gln Gly Ala Met Glu Met Leu Gly Ile Ser
                805                 810                 815     
Glu Ser Glu Gln Arg Ala Val Trp Arg Val Leu Ala Ala Ile Tyr His
            820                 825                 830         
Leu Gly Ala Ala Gly Ala Cys Lys Val Gly Arg Lys Gln Phe Met Arg
        835                 840                 845             
Phe Glu Trp Ala Asn Tyr Ala Ala Glu Ala Leu Gly Cys Glu Tyr Glu
    850                 855                 860                 
Glu Leu Asn Thr Ala Thr Phe Lys His His Leu Arg Gln Ile Ile Gln
865                 870                 875                 880 
Gln Met Thr Phe Gly Pro Ser Arg Trp Gly Leu Glu Asp Glu Glu Thr
                885                 890                 895     
Ser Ser Gly Leu Lys Met Thr Gly Val Asp Cys Val Glu Gly Met Ala
            900                 905                 910         
Ser Gly Leu Tyr Gln Glu Leu Phe Ala Ala Val Val Ser Leu Ile Asn
        915                 920                 925             
Arg Ser Phe Ser Ser His His Leu Ser Met Ala Ser Ile Met Val Val
    930                 935                 940                 
Asp Ser Pro Gly Phe Gln Asn Pro Arg His Gln Gly Lys Asp Arg Ala
945                 950                 955                 960 
Ala Thr Phe Glu Glu Leu Cys His Asn Tyr Ala His Glu Arg Leu Gln
                965                 970                 975     
Leu Leu Phe Tyr Gln Arg Thr Phe Val Ser Thr Leu Gln Arg Tyr Gln
            980                 985                 990         
Glu Glu Gly Val Pro Val Gln Phe Asp Leu Pro Asp Pro Ser Pro Gly
        995                 1000                1005            
Thr Thr Val Ala Val Val Asp Gln Asn Pro Ser Gln Val Arg Leu Pro
    1010                1015                1020                
Ala Gly Gly Gly Ala Gln Asp Ala Arg Gly Leu Phe Trp Val Leu Asp
1025                1030                1035                1040
Glu Glu Val His Val Glu Gly Ser Ser Asp Ser Val Val Leu Glu Arg
                1045                1050                1055    
Leu Cys Ala Ala Phe Glu Lys Lys Gly Ala Gly Thr Glu Gly Ser Ser
            1060                1065                1070        
Ala Leu Arg Thr Cys Glu Gln Pro Leu Gln Cys Glu Ile Phe His Gln
        1075                1080                1085            
Leu Gly Trp Asp Pro Val Arg Tyr Asp Leu Thr Gly Trp Leu His Arg
    1090                1095                1100                
Ala Lys Pro Asn Leu Ser Ala Leu Asp Ala Pro Gln Val Leu His Gln
1105                1110                1115                1120
Ser Lys Arg Glu Glu Leu Arg Ser Leu Phe Gln Ala Arg Ala Lys Leu
                1125                1130                1135    
Pro Pro Val Cys Arg Ala Val Ala Gly Leu Glu Gly Thr Ser Gln Gln
            1140                1145                1150        
Ala Leu Gln Arg Ser Arg Met Val Arg Arg Thr Phe Ala Ser Ser Leu
        1155                1160                1165            
Ala Ala Val Arg Arg Lys Ala Pro Cys Ser Gln Ile Lys Leu Gln Met
    1170                1175                1180                
Asp Ala Leu Thr Ser Met Ile Lys Arg Ser Arg Leu His Phe Ile His
1185                1190                1195                1200
Cys Leu Val Pro Asn Pro Val Val Glu Ser Arg Ser Gly Gln Glu Ser
                1205                1210                1215    
Pro Pro Pro Pro Gln Pro Gly Arg Asp Lys Pro Gly Ala Gly Gly Pro
            1220                1225                1230        
Leu Ala Leu Asp Ile Pro Ala Leu Arg Val Gln Leu Ala Gly Phe His
        1235                1240                1245            
Ile Leu Glu Ala Leu Arg Leu His Arg Thr Gly Tyr Ala Asp His Met
    1250                1255                1260                
Gly Leu Thr Arg Phe Arg Arg Gln Phe Gln Val Leu Asp Ala Pro Leu
1265                1270                1275                1280
Leu Lys Lys Leu Met Ser Thr Ser Glu Gly Ile Asp Glu Arg Lys Ala
                1285                1290                1295    
Val Glu Glu Leu Leu Glu Thr Leu Asp Leu Glu Lys Lys Ala Val Ala
            1300                1305                1310        
Val Gly His Ser Gln Val Phe Leu Lys Ala Gly Val Ile Ser Arg Leu
        1315                1320                1325            
Glu Lys Gln Arg Glu Lys Leu Val Ser Gln Ser Ile Val Leu Phe Gln
    1330                1335                1340                
Ala Ala Cys Lys Gly Phe Leu Ser Arg Gln Glu Phe Lys Lys Leu Lys
1345                1350                1355                1360
Ile Arg Arg Leu Ala Ala Gln Cys Ile Gln Lys Asn Val Ala Val Phe
                1365                1370                1375    
Leu Ala Val Lys Asp Trp Pro Trp Trp Gln Leu Leu Gly Ser Leu Gln
            1380                1385                1390        
Pro Leu Leu Ser Ala Thr Ile Gly Thr Glu Gln Leu Arg Ala Lys Glu
        1395                1400                1405            
Glu Glu Leu Thr Thr Leu Arg Arg Lys Leu Glu Lys Ser Glu Lys Leu
    1410                1415                1420                
Arg Asn Glu Leu Arg Gln Asn Thr Asp Leu Leu Glu Ser Lys Ile Ala
1425                1430                1435                1440
Asp Leu Thr Ser Asp Leu Ala Asp Glu Arg Phe Lys Gly Asp Val Ala
                1445                1450                1455    
Cys Gln Val Leu Glu Ser Glu Arg Ala Glu Arg Leu Gln Ala Phe Arg
            1460                1465                1470        
Glu Val Gln Glu Leu Lys Ser Lys His Glu Gln Val Gln Lys Lys Leu
        1475                1480                1485            
Gly Asp Val Asn Lys Gln Leu Glu Glu Ala Gln Gln Lys Ile Gln Leu
    1490                1495                1500                
Asn Asp Leu Glu Arg Asn Pro Thr Gly Gly Ala Asp Glu Trp Gln Met
1505                1510                1515                1520
Arg Phe Asp Cys Ala Gln Met Glu Asn Glu Phe Leu Arg Lys Arg Leu
                1525                1530                1535    
Gln Gln Cys Glu Glu Arg Leu Asp Ser Glu Leu Thr Ala Arg Lys Glu
            1540                1545                1550        
Leu Glu Gln Lys Leu Gly Glu Leu Gln Ser Ala Tyr Asp Gly Ala Lys
        1555                1560                1565            
Lys Met Ala His Gln Leu Lys Arg Lys Cys His His Leu Thr Cys Asp
    1570                1575                1580                
Leu Glu Asp Thr Cys Val Leu Leu Glu Asn Gln Gln Ser Arg Asn His
1585                1590                1595                1600
Glu Leu Glu Lys Lys Gln Lys Lys Phe Asp Leu Gln Leu Ala Gln Ala
                1605                1610                1615    
Leu Gly Glu Ser Val Phe Glu Lys Gly Leu Arg Glu Lys Val Thr Gln
            1620                1625                1630        
Glu Asn Thr Ser Val Arg Trp Glu Leu Gly Gln Leu Gln Gln Gln Leu
        1635                1640                1645            
Lys Gln Lys Glu Gln Glu Ala Ser Gln Leu Lys Gln Gln Val Glu Met
    1650                1655                1660                
Leu Gln Asp His Lys Arg Glu Leu Leu Gly Ser Pro Ser Leu Gly Glu
1665                1670                1675                1680
Asn Cys Val Ala Gly Leu Lys Glu Arg Leu Trp Lys Leu Glu Ser Ser
                1685                1690                1695    
Ala Leu Glu Gln Gln Lys Ile Gln Ser Gln Gln Glu Asn Thr Ile Lys
            1700                1705                1710        
Gln Leu Glu Gln Leu Arg Gln Arg Phe Glu Leu Glu Ile Glu Arg Met
        1715                1720                1725            
Lys Gln Met His Gln Lys Asp Arg Glu Asp Gln Glu Glu Glu Leu Glu
    1730                1735                1740                
Asp Val Arg Gln Ser Cys Gln Lys Arg Leu His Gln Leu Glu Met Gln
1745                1750                1755                1760
Leu Glu Gln Glu Tyr Glu Glu Lys Gln Met Val Leu His Glu Lys Gln
                1765                1770                1775    
Asp Leu Glu Gly Leu Ile Gly Thr Leu Cys Asp Gln Ile Gly His Arg
            1780                1785                1790        
Asp Phe Asp Val Glu Lys Arg Leu Arg Arg Asp Leu Arg Arg Thr His
        1795                1800                1805            
Ala Leu Leu Ser Asp Val Gln Leu Leu Leu Gly Thr Met Glu Asp Gly
    1810                1815                1820                
Lys Thr Ser Val Ser Lys Glu Glu Leu Glu Lys Val His Ser Gln Leu
1825                1830                1835                1840
Glu Gln Ser Glu Ala Lys Cys Glu Glu Ala Leu Lys Thr Gln Lys Val
                1845                1850                1855    
Leu Thr Ala Asp Leu Glu Ser Met His Ser Glu Leu Glu Asn Met Thr
            1860                1865                1870        
Arg Asn Lys Ser Leu Val Asp Glu Gln Leu Tyr Arg Leu Gln Phe Glu
        1875                1880                1885            
Lys Ala Asp Leu Leu Lys Arg Ile Asp Glu Asp Gln Asp Asp Leu Asn
    1890                1895                1900                
Glu Leu Met Gln Lys His Lys Asp Leu Ile Ala Gln Ser Ala Ala Asp
1905                1910                1915                1920
Ile Gly Gln Ile Gln Glu Leu Gln Leu Gln Leu Glu Glu Ala Lys Lys
                1925                1930                1935    
Glu Lys His Lys Leu Gln Glu Gln Leu Gln Val Ala Gln Met Arg Ile
            1940                1945                1950        
Glu Tyr Leu Glu Gln Ser Thr Val Asp Arg Ala Ile Val Ser Arg Gln
        1955                1960                1965            
Glu Ala Val Ile Cys Asp Leu Glu Asn Lys Thr Glu Phe Gln Lys Val
    1970                1975                1980                
Gln Ile Lys Arg Phe Glu Val Leu Val Ile Arg Leu Arg Asp Ser Leu
1985                1990                1995                2000
Ile Lys Met Gly Glu Glu Leu Ser Gln Ala Ala Thr Ser Glu Ser Gln
                2005                2010                2015    
Gln Arg Glu Ser Ser Gln Tyr Tyr Gln Arg Arg Leu Glu Glu Leu Lys
            2020                2025                2030        
Ala Asp Met Glu Glu Leu Val Gln Arg Glu Ala Glu Ala Ser Arg Arg
        2035                2040                2045            
Cys Met Glu Leu Glu Lys Tyr Val Glu Glu Leu Ala Ala Val Arg Gln
    2050                2055                2060                
Thr Leu Gln Thr Asp Leu Glu Thr Ser Ile Arg Arg Ile Ala Asp Leu
2065                2070                2075                2080
Gln Ala Ala Leu Glu Glu Val Ala Ser Ser Asp Ser Asp Thr Glu Ser
                2085                2090                2095    
Val Gln Thr Ala Val Asp Cys Gly Ser Ser Gly Arg Lys Glu Met Asp
            2100                2105                2110        
Asn Val Ser Ile Leu Ser Ser Gln Pro Glu Gly Ser Leu Gln Ser Trp
        2115                2120                2125            
Leu Ser Cys Thr Leu Ser Leu Ala Thr Asp Thr Met Arg Thr Pro Ser
    2130                2135                2140                
Arg Gln Ser Ala Thr Ser Ser Arg Ile Leu Ser Pro Arg Ile Asn Glu
2145                2150                2155                2160
Glu Ala Gly Asp Thr Glu Arg Thr Gln Ser Ala Leu Ala Leu Ser Arg
                2165                2170                2175    
Ala Arg Ser Thr Asn Val His Ser Lys Thr Ser Gly Asp Lys Pro Val
            2180                2185                2190        
Ser Pro His Phe Val Arg Arg Gln Lys Tyr Cys His Phe Gly Asp Gly
        2195                2200                2205            
Glu Val Leu Ala Val Gln Arg Lys Ser Thr Glu Arg Leu Glu Pro Ala
    2210                2215                2220                
Ser Ser Pro Leu Ala Ser Arg Ser Thr Asn Thr Ser Pro Leu Ser Arg
2225                2230                2235                2240
Glu Lys Leu Pro Ser Pro Ser Ala Ala Leu Ser Glu Phe Val Glu Gly
                2245                2250                2255    
Leu Arg Arg Lys Arg Ala Gln Arg Gly Gln Gly Ser Thr Leu Gly Leu
            2260                2265                2270        
Glu Asp Trp Pro Thr Leu Pro Ile Tyr Gln Thr Thr Gly Ala Ser Thr
        2275                2280                2285            
Leu Arg Arg Gly Arg Ala Gly Ser Asp Glu Gly Asn Leu Ser Leu Arg
    2290                2295                2300                
Val Gly Ala Lys Ser Pro Leu Glu Ile Glu Gly Ala Ala Gly Gly Leu
2305                2310                2315                2320
Leu Arg Ser Thr Ser Leu Lys Cys Ile Ser Ser Asp Gly Val Gly Gly
                2325                2330                2335    
Thr Thr Leu Leu Pro Glu Lys Ser Lys Thr Gln Phe Ser Ser Cys Glu
            2340                2345                2350        
Ser Leu Leu Glu Ser Arg Pro Ser Met Gly Arg Lys Leu Ser Ser Pro
        2355                2360                2365            
Thr Thr Pro Arg Asp Met Leu Leu Ser Pro Thr Leu Arg Pro Arg Arg
    2370                2375                2380                
Arg Cys Leu Glu Ser Ser Val Asp Asp Ala Gly Cys Pro Asp Leu Gly
2385                2390                2395                2400
Lys Glu Pro Leu Val Phe Gln Asn Arg Gln Phe Ala His Leu Met Glu
                2405                2410                2415    
Glu Pro Leu Gly Ser Asp Pro Phe Ser Trp Lys Leu Pro Ser Leu Asp
            2420                2425                2430        
Tyr Glu Arg Lys Thr Lys Val Asp Phe Asp Asp Phe Leu Pro Ala Ile
        2435                2440                2445            
Arg Lys Pro Gln Thr Pro Thr Ser Leu Ala Gly Ser Ala Lys Gly Gly
    2450                2455                2460                
Gln Asp Gly Ser Gln Arg Ser Ser Ile His Phe Glu Thr Glu Glu Ala
2465                2470                2475                2480
Asn Arg Ser Phe Leu Ser Gly Ile Lys Thr Ile Leu Lys Lys Ser Pro
                2485                2490                2495    
Glu Pro Lys Glu Asp Pro Ala His Leu Ser Asp Ser Ser Ser Ser Ser
            2500                2505                2510        
Gly Ser Ile Val Ser Phe Lys Ser Ala Asp Ser Ile Lys Ser Arg Pro
        2515                2520                2525            
Gly Ile Pro Arg Leu Ala Gly Asp Gly Gly Glu Arg Thr Ser Pro Glu
    2530                2535                2540                
Arg Arg Glu Pro Gly Thr Gly Arg Lys Asp Asp Asp Val Ala Ser Ile
2545                2550                2555                2560
Met Lys Lys Tyr Leu Gln Lys
                2565        


<210> 7151
<211> 450
<212> PRT
<213> Homo sapiens

<400> 7151
Gly Arg Lys Gln Phe Met Arg Phe Glu Trp Ala Asn Tyr Ala Ala Glu
 1               5                  10                  15      
Ala Leu Gly Cys Glu Tyr Glu Glu Leu Asn Thr Ala Thr Phe Lys His
            20                  25                  30          
His Leu Arg Gln Ile Ile Gln Gln Met Thr Phe Gly Pro Ser Arg Trp
        35                  40                  45              
Gly Leu Glu Asp Glu Glu Thr Ser Ser Gly Leu Lys Met Thr Gly Val
    50                  55                  60                  
Asp Cys Val Glu Gly Met Ala Ser Gly Leu Tyr Gln Glu Leu Phe Ala
65                  70                  75                  80  
Ala Val Val Ser Leu Ile Asn Arg Ser Phe Ser Ser His His Leu Ser
                85                  90                  95      
Met Ala Ser Ile Met Val Val Asp Ser Pro Gly Phe Gln Asn Pro Arg
            100                 105                 110         
His Gln Gly Lys Asp Arg Ala Ala Thr Phe Glu Glu Leu Cys His Asn
        115                 120                 125             
Tyr Ala His Glu Arg Leu Gln Leu Leu Phe Tyr Gln Arg Thr Phe Val
    130                 135                 140                 
Ser Thr Leu Gln Arg Tyr Gln Glu Val Cys Leu Gly Trp Ser Arg Ala
145                 150                 155                 160 
Phe Thr Arg Ala Pro Trp Met Val Glu Ser Trp Phe Ser Gln Gln Val
                165                 170                 175     
Arg Leu Pro Ala Gly Gly Gly Ala Gln Asp Ala Arg Gly Leu Phe Trp
            180                 185                 190         
Val Leu Asp Glu Glu Val His Val Glu Gly Ser Ser Asp Ser Val Val
        195                 200                 205             
Leu Glu Arg Leu Cys Ala Ala Phe Glu Lys Lys Gly Ala Gly Thr Glu
    210                 215                 220                 
Gly Ser Ser Ala Leu Arg Thr Cys Glu Gln Pro Leu Gln Cys Glu Ile
225                 230                 235                 240 
Phe His Gln Leu Gly Trp Asp Pro Val Arg Tyr Asp Leu Thr Gly Trp
                245                 250                 255     
Leu His Arg Ala Lys Pro Asn Leu Ser Ala Leu Asp Ala Pro Gln Val
            260                 265                 270         
Leu His Gln Ser Lys Arg Glu Glu Leu Arg Ser Leu Phe Gln Ala Arg
        275                 280                 285             
Ala Lys Leu Pro Pro Val Cys Arg Ala Val Ala Gly Leu Glu Gly Thr
    290                 295                 300                 
Ser Gln Gln Ala Leu Gln Arg Ser Arg Met Val Arg Arg Thr Phe Ala
305                 310                 315                 320 
Ser Ser Leu Ala Ala Val Arg Arg Lys Ala Pro Cys Ser Gln Ile Lys
                325                 330                 335     
Leu Gln Met Asp Ala Leu Thr Ser Met Ile Lys Arg Ser Arg Leu His
            340                 345                 350         
Phe Ile His Cys Leu Val Pro Asn Pro Val Val Glu Ser Arg Ser Gly
        355                 360                 365             
Gln Glu Ser Pro Pro Pro Pro Gln Pro Gly Arg Asp Lys Pro Gly Ala
    370                 375                 380                 
Gly Gly Pro Leu Ala Leu Asp Ile Pro Ala Leu Arg Val Gln Leu Ala
385                 390                 395                 400 
Gly Phe His Ile Leu Glu Ala Leu Arg Leu His Arg Thr Gly Tyr Ala
                405                 410                 415     
Asp His Met Gly Leu Thr Arg Phe Arg Arg Gln Phe Gln Val Leu Asp
            420                 425                 430         
Ala Pro Leu Leu Lys Lys Leu Met Ser Thr Ser Glu Gly Ile Asp Glu
        435                 440                 445             
Arg Lys
    450 


<210> 7152
<211> 876
<212> PRT
<213> Homo sapiens

<400> 7152
Met Val Val Asn Gly Arg Arg Asn Gly Gly Lys Leu Ser Asn Asp His
 1               5                  10                  15      
Gln Gln Asn Gln Ser Lys Leu Gln His Thr Gly Lys Asp Thr Leu Lys
            20                  25                  30          
Ala Gly Lys Asn Ala Val Glu Arg Arg Ser Asn Arg Cys Asn Gly Asn
        35                  40                  45              
Ser Gly Phe Glu Gly Gln Ser Arg Tyr Val Pro Ser Ser Gly Met Ser
    50                  55                  60                  
Ala Lys Glu Leu Cys Glu Asn Asp Asp Leu Ala Thr Ser Leu Val Leu
65                  70                  75                  80  
Asp Pro Tyr Leu Gly Phe Gln Thr His Lys Met Asn Thr Ser Ala Phe
                85                  90                  95      
Pro Ser Arg Ser Ser Arg His Phe Ser Lys Ser Asp Ser Phe Ser His
            100                 105                 110         
Asn Asn Pro Val Arg Phe Arg Pro Ile Lys Gly Arg Gln Glu Glu Leu
        115                 120                 125             
Lys Glu Val Ile Glu Arg Phe Lys Lys Asp Glu His Leu Glu Lys Ala
    130                 135                 140                 
Phe Lys Cys Leu Thr Ser Gly Glu Trp Ala Arg His Tyr Phe Leu Asn
145                 150                 155                 160 
Lys Asn Lys Met Gln Glu Lys Leu Phe Lys Glu His Val Phe Ile Tyr
                165                 170                 175     
Leu Arg Met Phe Ala Thr Asp Ser Gly Phe Glu Ile Leu Pro Cys Asn
            180                 185                 190         
Arg Tyr Ser Ser Glu Gln Asn Gly Ala Lys Ile Val Ala Thr Lys Glu
        195                 200                 205             
Trp Lys Arg Asn Asp Lys Ile Glu Leu Leu Val Gly Cys Ile Ala Glu
    210                 215                 220                 
Leu Ser Glu Ile Glu Glu Asn Met Leu Leu Arg His Gly Glu Asn Asp
225                 230                 235                 240 
Phe Ser Val Met Tyr Ser Thr Arg Lys Asn Cys Ala Gln Leu Trp Leu
                245                 250                 255     
Gly Pro Ala Ala Phe Ile Asn His Asp Cys Arg Pro Asn Cys Lys Phe
            260                 265                 270         
Val Ser Thr Gly Arg Asp Thr Ala Cys Val Lys Ala Leu Arg Asp Ile
        275                 280                 285             
Glu Pro Gly Glu Glu Ile Ser Cys Tyr Tyr Gly Asp Gly Phe Phe Gly
    290                 295                 300                 
Glu Asn Asn Glu Phe Cys Glu Cys Tyr Thr Cys Glu Arg Arg Gly Thr
305                 310                 315                 320 
Gly Ala Phe Lys Ser Arg Val Gly Leu Pro Ala Pro Ala Pro Val Ile
                325                 330                 335     
Asn Ser Lys Tyr Gly Leu Arg Glu Thr Asp Lys Arg Leu Asn Arg Leu
            340                 345                 350         
Lys Lys Leu Gly Asp Ser Ser Lys Asn Ser Asp Ser Gln Ser Val Ser
        355                 360                 365             
Ser Asn Thr Asp Ala Asp Thr Thr Gln Glu Lys Asn Asn Ala Thr Ser
    370                 375                 380                 
Asn Arg Lys Ser Ser Val Gly Val Lys Lys Asn Ser Lys Ser Arg Thr
385                 390                 395                 400 
Leu Thr Arg Gln Ser Met Ser Arg Ile Pro Ala Ser Ser Asn Ser Thr
                405                 410                 415     
Ser Ser Lys Leu Thr His Ile Asn Asn Ser Arg Val Pro Lys Lys Leu
            420                 425                 430         
Lys Lys Pro Ala Lys Pro Leu Leu Ser Lys Ile Lys Leu Arg Asn His
        435                 440                 445             
Cys Lys Arg Leu Glu Gln Lys Asn Ala Ser Arg Lys Leu Glu Met Gly
    450                 455                 460                 
Asn Leu Val Leu Lys Glu Pro Lys Val Val Leu Tyr Lys Asn Leu Pro
465                 470                 475                 480 
Ile Lys Lys Asp Lys Glu Pro Glu Gly Pro Ala Gln Ala Ala Val Ala
                485                 490                 495     
Ser Gly Cys Leu Thr Arg His Ala Ala Arg Glu His Arg Gln Asn Pro
            500                 505                 510         
Val Arg Gly Ala His Ser Gln Gly Glu Ser Ser Pro Cys Thr Tyr Ile
        515                 520                 525             
Thr Arg Arg Ser Val Arg Thr Arg Thr Asn Leu Lys Glu Ala Ser Asp
    530                 535                 540                 
Ile Lys Leu Glu Pro Asn Thr Leu Asn Gly Tyr Lys Ser Ser Val Thr
545                 550                 555                 560 
Glu Pro Cys Pro Asp Ser Gly Glu Gln Leu Gln Pro Ala Pro Val Leu
                565                 570                 575     
Gln Glu Glu Glu Leu Ala His Glu Thr Ala Gln Lys Gly Glu Ala Lys
            580                 585                 590         
Cys His Lys Ser Asp Thr Gly Met Ser Lys Lys Lys Ser Arg Gln Gly
        595                 600                 605             
Lys Leu Val Lys Gln Phe Ala Lys Ile Glu Glu Ser Thr Pro Val His
    610                 615                 620                 
Asp Ser Pro Gly Lys Asp Asp Ala Val Pro Asp Leu Met Gly Pro His
625                 630                 635                 640 
Ser Asp Gln Gly Glu His Ser Gly Thr Val Gly Val Pro Val Ser Tyr
                645                 650                 655     
Thr Asp Cys Ala Pro Ser Pro Val Gly Cys Ser Val Val Thr Ser Asp
            660                 665                 670         
Ser Phe Lys Thr Lys Asp Ser Phe Arg Thr Ala Lys Ser Lys Lys Lys
        675                 680                 685             
Arg Arg Ile Thr Arg Tyr Asp Ala Gln Leu Ile Leu Glu Asn Asn Ser
    690                 695                 700                 
Gly Ile Pro Lys Leu Thr Leu Arg Arg Arg His Asp Ser Ser Ser Lys
705                 710                 715                 720 
Thr Asn Asp Gln Glu Asn Asp Gly Met Asn Ser Ser Lys Ile Ser Ile
                725                 730                 735     
Lys Leu Ser Lys Asp His Asp Asn Asp Asn Asn Leu Tyr Val Ala Lys
            740                 745                 750         
Leu Asn Asn Gly Phe Asn Ser Gly Ser Gly Ser Ser Ser Thr Lys Leu
        755                 760                 765             
Lys Ile Gln Leu Lys Arg Asp Glu Glu Asn Arg Gly Ser Tyr Thr Glu
    770                 775                 780                 
Gly Leu His Glu Asn Gly Val Cys Cys Ser Asp Pro Leu Ser Leu Leu
785                 790                 795                 800 
Glu Ser Arg Met Glu Val Asp Asp Tyr Ser Gln Tyr Glu Glu Glu Ser
                805                 810                 815     
Thr Asp Asp Ser Ser Ser Ser Glu Gly Asp Glu Glu Glu Asp Asp Tyr
            820                 825                 830         
Asp Asp Asp Phe Glu Asp Asp Phe Ile Pro Leu Pro Pro Ala Lys Arg
        835                 840                 845             
Leu Arg Leu Ile Val Gly Lys Asp Ser Ile Asp Ile Asp Ile Ser Ser
    850                 855                 860                 
Arg Arg Arg Glu Asp Gln Ser Leu Arg Leu Asn Ala
865                 870                 875     


<210> 7153
<211> 2385
<212> PRT
<213> Homo sapiens

<400> 7153
Met Pro Val Leu Gly Val Ala Ser Lys Leu Arg Gln Pro Ala Val Gly
 1               5                  10                  15      
Ser Lys Pro Val His Thr Ala Leu Pro Ile Pro Asn Leu Gly Thr Thr
            20                  25                  30          
Gly Ser Gln His Cys Ser Ser Arg Pro Leu Glu Leu Ala Glu Thr Glu
        35                  40                  45              
Ser Ser Met Leu Ser Cys Gln Leu Ala Leu Lys Ser Thr Cys Glu Phe
    50                  55                  60                  
Gly Glu Lys Lys Pro Leu Gln Gly Lys Ala Lys Glu Lys Glu Asp Ser
65                  70                  75                  80  
Lys Ile Tyr Thr Asp Trp Ala Asn His Tyr Leu Ala Lys Ser Gly His
                85                  90                  95      
Lys Arg Leu Ile Lys Asp Leu Gln Gln Asp Ile Ala Asp Gly Val Leu
            100                 105                 110         
Leu Ala Glu Ile Ile Gln Ile Ile Ala Asn Glu Lys Val Glu Asp Ile
        115                 120                 125             
Asn Gly Cys Pro Arg Ser Gln Ser Gln Met Ile Glu Asn Val Asp Val
    130                 135                 140                 
Cys Leu Ser Phe Leu Ala Ala Arg Gly Val Asn Val Gln Gly Leu Ser
145                 150                 155                 160 
Ala Glu Glu Ile Arg Asn Gly Asn Leu Lys Ala Ile Leu Gly Leu Phe
                165                 170                 175     
Phe Ser Leu Ser Arg Tyr Lys Gln Gln Gln His His Gln Gln Gln Tyr
            180                 185                 190         
Tyr Gln Ser Leu Val Glu Leu Gln Gln Arg Val Thr His Ala Ser Pro
        195                 200                 205             
Pro Ser Glu Ala Ser Gln Ala Lys Thr Gln Gln Asp Met Gln Ser Ser
    210                 215                 220                 
Leu Ala Ala Arg Tyr Ala Thr Gln Ser Asn His Ser Gly Ile Ala Thr
225                 230                 235                 240 
Ser Gln Lys Lys Pro Thr Arg Leu Pro Gly Pro Ser Arg Val Pro Ala
                245                 250                 255     
Ala Gly Ser Ser Ser Lys Val Gln Gly Ala Ser Asn Leu Asn Arg Arg
            260                 265                 270         
Ser Gln Ser Phe Asn Ser Ile Asp Lys Asn Lys Pro Pro Asn Tyr Ala
        275                 280                 285             
Asn Gly Asn Glu Lys Asp Ser Ser Lys Gly Pro Gln Ser Ser Ser Gly
    290                 295                 300                 
Val Asn Gly Asn Val Gln Pro Pro Ser Thr Ala Gly Gln Pro Pro Ala
305                 310                 315                 320 
Ser Ala Ile Pro Ser Pro Ser Ala Ser Lys Pro Trp Arg Ser Lys Ser
                325                 330                 335     
Met Asn Val Lys His Ser Ala Thr Ser Thr Met Leu Thr Val Lys Gln
            340                 345                 350         
Ser Ser Thr Ala Thr Ser Pro Thr Pro Ser Ser Asp Arg Leu Lys Pro
        355                 360                 365             
Pro Val Ser Glu Gly Val Lys Thr Ala Pro Ser Gly Gln Lys Ser Met
    370                 375                 380                 
Leu Glu Lys Phe Lys Leu Val Asn Ala Arg Thr Ala Leu Arg Pro Pro
385                 390                 395                 400 
Gln Pro Pro Ser Ser Gly Pro Ser Asp Gly Gly Lys Asp Asp Asp Ala
                405                 410                 415     
Phe Ser Glu Ser Gly Glu Met Glu Gly Phe Asn Ser Gly Leu Asn Ser
            420                 425                 430         
Gly Gly Ser Thr Asn Ser Ser Pro Lys Val Ser Pro Lys Leu Ala Pro
        435                 440                 445             
Pro Lys Ala Gly Ser Lys Asn Leu Ser Asn Lys Lys Ser Leu Leu Gln
    450                 455                 460                 
Pro Lys Glu Lys Glu Glu Lys Asn Arg Asp Lys Asn Lys Val Cys Thr
465                 470                 475                 480 
Glu Lys Pro Val Lys Glu Glu Lys Asp Gln Val Thr Glu Met Ala Pro
                485                 490                 495     
Lys Lys Thr Ser Lys Ile Ala Ser Leu Ile Pro Lys Gly Ser Lys Thr
            500                 505                 510         
Thr Ala Ala Lys Lys Glu Ser Leu Ile Pro Ser Ser Ser Gly Ile Pro
        515                 520                 525             
Lys Pro Gly Ser Lys Val Pro Thr Val Lys Gln Thr Ile Ser Pro Gly
    530                 535                 540                 
Ser Thr Ala Ser Lys Glu Ser Glu Lys Phe Arg Thr Thr Lys Gly Ser
545                 550                 555                 560 
Pro Ser Gln Ser Leu Ser Lys Pro Ile Thr Met Glu Lys Ala Ser Ala
                565                 570                 575     
Ser Ser Cys Pro Ala Pro Leu Glu Gly Arg Glu Ala Gly Gln Ala Ser
            580                 585                 590         
Pro Ser Gly Ser Cys Thr Met Thr Val Ala Gln Ser Ser Gly Gln Ser
        595                 600                 605             
Thr Gly Asn Gly Ala Val Gln Leu Pro Gln Gln Gln Gln His Ser His
    610                 615                 620                 
Pro Asn Thr Ala Thr Val Ala Pro Phe Ile Tyr Arg Ala His Ser Glu
625                 630                 635                 640 
Asn Glu Gly Thr Ala Leu Pro Ser Ala Asp Ser Cys Thr Ser Pro Thr
                645                 650                 655     
Lys Met Asp Leu Ser Tyr Ser Lys Thr Ala Lys Gln Cys Leu Glu Glu
            660                 665                 670         
Ile Ser Gly Glu Gly Pro Glu Thr Arg Arg Met Arg Thr Val Lys Asn
        675                 680                 685             
Ile Ala Asp Leu Arg Gln Asn Leu Glu Glu Thr Met Ser Ser Leu Arg
    690                 695                 700                 
Gly Thr Gln Ile Ser His Ser Thr Leu Glu Thr Thr Phe Asp Ser Thr
705                 710                 715                 720 
Val Thr Thr Glu Val Asn Gly Arg Thr Ile Pro Asn Leu Thr Ser Arg
                725                 730                 735     
Pro Thr Pro Met Thr Trp Arg Leu Gly Gln Ala Cys Pro Arg Leu Gln
            740                 745                 750         
Ala Gly Asp Ala Pro Ser Leu Gly Ala Gly Tyr Pro Arg Ser Gly Thr
        755                 760                 765             
Ser Arg Phe Ile His Thr Asp Pro Ser Arg Phe Met Tyr Thr Thr Pro
    770                 775                 780                 
Leu Arg Arg Ala Ala Val Ser Arg Leu Gly Asn Met Ser Gln Ile Asp
785                 790                 795                 800 
Met Ser Glu Lys Ala Ser Ser Asp Leu Asp Met Ser Ser Glu Val Asp
                805                 810                 815     
Val Gly Gly Tyr Met Ser Asp Gly Asp Ile Leu Gly Lys Ser Leu Arg
            820                 825                 830         
Thr Asp Asp Ile Asn Ser Gly Tyr Met Thr Asp Gly Gly Leu Asn Leu
        835                 840                 845             
Tyr Thr Arg Ser Leu Asn Arg Ile Pro Asp Thr Ala Thr Ser Arg Asp
    850                 855                 860                 
Ile Ile Gln Arg Gly Val His Asp Val Thr Val Asp Ala Asp Ser Trp
865                 870                 875                 880 
Asp Asp Ser Ser Ser Val Ser Ser Gly Leu Ser Asp Thr Leu Asp Asn
                885                 890                 895     
Ile Ser Thr Asp Asp Leu Asn Thr Thr Ser Ser Val Ser Ser Tyr Ser
            900                 905                 910         
Asn Ile Thr Val Pro Ser Arg Lys Asn Thr Gln Leu Arg Thr Asp Ser
        915                 920                 925             
Glu Lys Arg Ser Thr Thr Asp Glu Thr Trp Asp Ser Pro Glu Glu Leu
    930                 935                 940                 
Lys Lys Pro Glu Glu Asp Phe Asp Ser His Gly Asp Ala Gly Gly Lys
945                 950                 955                 960 
Trp Lys Thr Val Ser Ser Gly Leu Pro Glu Asp Pro Glu Lys Ala Gly
                965                 970                 975     
Gln Lys Ala Ser Leu Ser Val Ser Gln Thr Gly Ser Trp Arg Arg Gly
            980                 985                 990         
Met Ser Ala Gln Gly Gly Ala Pro Ser Arg Gln Lys Ala Gly Thr Ser
        995                 1000                1005            
Ala Leu Lys Thr Pro Gly Lys Thr Asp Asp Ala Lys Ala Ser Glu Lys
    1010                1015                1020                
Gly Lys Ala Pro Leu Lys Gly Ser Ser Leu Gln Arg Ser Pro Ser Asp
1025                1030                1035                1040
Ala Gly Lys Ser Ser Gly Asp Glu Gly Lys Lys Pro Pro Ser Gly Ile
                1045                1050                1055    
Gly Arg Ser Thr Ala Thr Ser Ser Phe Gly Phe Lys Lys Pro Ser Gly
            1060                1065                1070        
Val Gly Ser Ser Ala Met Ile Thr Ser Ser Gly Ala Thr Ile Thr Ser
        1075                1080                1085            
Gly Ser Ala Thr Leu Gly Lys Ile Pro Lys Ser Ala Ala Ile Gly Gly
    1090                1095                1100                
Lys Ser Asn Ala Gly Arg Lys Thr Ser Leu Asp Gly Ser Gln Asn Gln
1105                1110                1115                1120
Asp Asp Val Val Leu His Val Ser Ser Lys Thr Thr Leu Gln Tyr Arg
                1125                1130                1135    
Ser Leu Pro Arg Pro Ser Lys Ser Ser Thr Ser Gly Ile Pro Gly Arg
            1140                1145                1150        
Gly Gly His Arg Ser Ser Thr Ser Ser Ile Asp Ser Asn Val Ser Ser
        1155                1160                1165            
Lys Ser Ala Gly Ala Thr Thr Ser Lys Leu Arg Glu Pro Thr Lys Ile
    1170                1175                1180                
Gly Ser Gly Arg Ser Ser Pro Val Thr Val Asn Gln Thr Asp Lys Glu
1185                1190                1195                1200
Lys Glu Lys Val Ala Val Ser Asp Ser Glu Ser Val Ser Leu Ser Gly
                1205                1210                1215    
Ser Pro Lys Ser Ser Pro Thr Ser Ala Ser Ala Cys Gly Ala Gln Gly
            1220                1225                1230        
Leu Arg Gln Pro Gly Ser Lys Tyr Pro Asp Ile Ala Ser Pro Thr Phe
        1235                1240                1245            
Arg Arg Leu Phe Gly Ala Lys Ala Gly Gly Lys Ser Ala Ser Ala Pro
    1250                1255                1260                
Asn Thr Glu Gly Val Lys Ser Ser Ser Val Met Pro Ser Pro Ser Thr
1265                1270                1275                1280
Thr Leu Ala Arg Gln Gly Ser Leu Glu Ser Pro Ser Ser Gly Thr Gly
                1285                1290                1295    
Ser Met Gly Ser Ala Gly Gly Leu Ser Gly Ser Ser Ser Pro Leu Phe
            1300                1305                1310        
Asn Lys Pro Ser Asp Leu Thr Thr Asp Val Ile Ser Leu Ser His Ser
        1315                1320                1325            
Leu Ala Ser Ser Pro Ala Ser Val His Ser Phe Thr Ser Gly Gly Leu
    1330                1335                1340                
Val Trp Ala Ala Asn Met Ser Ser Ser Ser Ala Gly Ser Lys Asp Thr
1345                1350                1355                1360
Pro Ser Tyr Gln Ser Met Thr Ser Leu His Thr Ser Ser Glu Ser Ile
                1365                1370                1375    
Asp Leu Pro Leu Ser His His Gly Ser Leu Ser Gly Leu Thr Thr Gly
            1380                1385                1390        
Thr His Glu Val Gln Ser Leu Leu Met Arg Thr Gly Ser Val Arg Ser
        1395                1400                1405            
Thr Leu Ser Glu Ser Met Gln Leu Asp Arg Asn Thr Leu Pro Lys Lys
    1410                1415                1420                
Gly Leu Arg Tyr Thr Pro Ser Ser Arg Gln Ala Asn Gln Glu Glu Gly
1425                1430                1435                1440
Lys Glu Trp Leu Arg Ser His Ser Thr Gly Gly Leu Gln Asp Thr Gly
                1445                1450                1455    
Asn Gln Ser Pro Leu Val Ser Pro Ser Ala Met Ser Ser Ser Ala Ala
            1460                1465                1470        
Gly Lys Tyr His Phe Ser Asn Leu Val Ser Pro Thr Asn Leu Ser Gln
        1475                1480                1485            
Phe Asn Leu Pro Gly Pro Ser Met Met Arg Ser Asn Ser Ile Pro Ala
    1490                1495                1500                
Gln Asp Ser Ser Phe Asp Leu Tyr Asp Asp Ser Gln Leu Cys Gly Ser
1505                1510                1515                1520
Ala Thr Ser Leu Glu Glu Arg Pro Arg Ala Ile Ser His Ser Gly Ser
                1525                1530                1535    
Phe Arg Asp Ser Met Glu Glu Val His Gly Ser Ser Leu Ser Leu Val
            1540                1545                1550        
Ser Ser Thr Ser Ser Leu Tyr Ser Thr Ala Glu Glu Lys Ala His Ser
        1555                1560                1565            
Glu Gln Ile His Lys Leu Arg Arg Glu Leu Val Ala Ser Gln Glu Lys
    1570                1575                1580                
Val Ala Thr Leu Thr Ser Gln Leu Ser Ala Asn Ala His Leu Val Ala
1585                1590                1595                1600
Ala Phe Glu Lys Ser Leu Gly Asn Met Thr Gly Arg Leu Gln Ser Leu
                1605                1610                1615    
Thr Met Thr Ala Glu Gln Lys Glu Ser Glu Leu Ile Glu Leu Arg Glu
            1620                1625                1630        
Thr Ile Glu Met Leu Lys Ala Gln Asn Ser Ala Ala Gln Ala Ala Ile
        1635                1640                1645            
Gln Gly Ala Leu Asn Gly Pro Asp His Pro Pro Lys Asp Leu Arg Ile
    1650                1655                1660                
Arg Arg Gln His Ser Ser Glu Ser Val Ser Ser Ile Asn Ser Ala Thr
1665                1670                1675                1680
Ser His Ser Ser Ile Gly Ser Gly Asn Asp Ala Asp Ser Lys Lys Lys
                1685                1690                1695    
Lys Lys Lys Asn Trp Val Asn Ser Arg Gly Ser Glu Leu Arg Ser Ser
            1700                1705                1710        
Phe Lys Gln Ala Phe Gly Lys Lys Lys Ser Thr Lys Pro Pro Ser Ser
        1715                1720                1725            
His Ser Asp Ile Glu Glu Leu Thr Asp Ser Ser Leu Pro Ala Ser Pro
    1730                1735                1740                
Lys Leu Pro His Asn Ala Gly Asp Cys Gly Ser Ala Ser Met Lys Pro
1745                1750                1755                1760
Ser Gln Ser Ala Ser Ala Ser Pro Leu Val Trp Pro Pro Lys Lys Arg
                1765                1770                1775    
Gln Asn Gly Pro Val Ile Tyr Lys His Arg Ser Arg Ile Cys Glu Cys
            1780                1785                1790        
Thr Glu Ala Glu Ala Glu Ile Ile Leu Gln Leu Lys Ser Glu Leu Arg
        1795                1800                1805            
Glu Lys Glu Leu Lys Leu Thr Asp Ile Arg Leu Glu Ala Leu Ser Ser
    1810                1815                1820                
Ala His His Leu Asp Gln Ile Arg Glu Ala Met Asn Arg Met Gln Asn
1825                1830                1835                1840
Glu Ile Glu Ile Leu Lys Ala Glu Asn Asp Arg Leu Lys Ala Glu Thr
                1845                1850                1855    
Gly Asn Thr Ala Lys Pro Thr Arg Pro Pro Ser Glu Ser Ser Ser Ser
            1860                1865                1870        
Thr Ser Ser Ser Ser Ser Arg Gln Ser Leu Gly Leu Ser Leu Asn Asn
        1875                1880                1885            
Leu Asn Ile Thr Glu Ala Val Ser Ser Asp Ile Leu Leu Asp Asp Ala
    1890                1895                1900                
Gly Asp Ala Thr Gly His Lys Asp Gly Arg Ser Val Lys Ile Ile Val
1905                1910                1915                1920
Ser Ile Ser Lys Gly Tyr Gly Arg Ala Lys Asp Gln Lys Ser Gln Ala
                1925                1930                1935    
Tyr Leu Ile Gly Ser Ile Gly Val Ser Gly Lys Thr Lys Trp Asp Val
            1940                1945                1950        
Leu Asp Gly Val Ile Arg Arg Leu Phe Lys Glu Tyr Val Phe Arg Ile
        1955                1960                1965            
Asp Thr Ser Thr Ser Leu Gly Leu Ser Ser Asp Cys Ile Ala Ser Tyr
    1970                1975                1980                
Cys Ile Gly Asp Leu Ile Arg Ser His Asn Leu Glu Val Pro Glu Leu
1985                1990                1995                2000
Leu Pro Cys Gly Tyr Leu Val Gly Asp Asn Asn Ile Ile Thr Val Asn
                2005                2010                2015    
Leu Lys Gly Val Glu Glu Asn Ser Leu Asp Ser Phe Val Phe Asp Thr
            2020                2025                2030        
Leu Ile Pro Lys Pro Ile Thr Gln Arg Tyr Phe Asn Leu Leu Met Glu
        2035                2040                2045            
His His Arg Ile Ile Leu Ser Gly Pro Ser Gly Thr Gly Lys Thr Tyr
    2050                2055                2060                
Leu Ala Asn Lys Leu Ala Glu Tyr Val Ile Thr Lys Ser Gly Arg Lys
2065                2070                2075                2080
Lys Thr Glu Asp Ala Ile Ala Thr Phe Asn Val Asp His Lys Ser Ser
                2085                2090                2095    
Lys Glu Leu Gln Gln Tyr Leu Ala Asn Leu Ala Glu Gln Cys Ser Ala
            2100                2105                2110        
Asp Asn Asn Gly Val Glu Leu Pro Val Val Ile Ile Leu Asp Asn Leu
        2115                2120                2125            
His His Val Gly Ser Leu Ser Asp Ile Phe Asn Gly Phe Leu Asn Cys
    2130                2135                2140                
Lys Tyr Asn Lys Cys Pro Tyr Ile Ile Gly Thr Met Asn Gln Gly Val
2145                2150                2155                2160
Ser Ser Ser Pro Asn Leu Glu Leu His His Asn Phe Arg Trp Val Leu
                2165                2170                2175    
Cys Ala Asn His Thr Glu Pro Val Lys Gly Phe Leu Gly Arg Tyr Leu
            2180                2185                2190        
Arg Arg Lys Leu Ile Glu Ile Glu Ile Glu Arg Asn Ile Arg Asn Asn
        2195                2200                2205            
Asp Leu Val Lys Ile Ile Asp Trp Ile Pro Lys Thr Trp His His Leu
    2210                2215                2220                
Asn Ser Phe Leu Glu Thr His Ser Ser Ser Asp Val Thr Ile Gly Pro
2225                2230                2235                2240
Arg Leu Phe Leu Pro Cys Pro Met Asp Val Glu Gly Ser Arg Val Trp
                2245                2250                2255    
Phe Met Asp Leu Trp Asn Tyr Ser Leu Val Pro Tyr Ile Leu Glu Ala
            2260                2265                2270        
Val Arg Glu Gly Leu Gln Met Tyr Gly Lys Arg Thr Pro Trp Glu Asp
        2275                2280                2285            
Pro Ser Lys Trp Val Leu Asp Thr Tyr Pro Trp Ser Ser Ala Thr Leu
    2290                2295                2300                
Pro Gln Glu Ser Pro Ala Leu Leu Gln Leu Arg Pro Glu Asp Val Gly
2305                2310                2315                2320
Tyr Glu Ser Cys Thr Ser Thr Lys Glu Ala Thr Thr Ser Lys His Ile
                2325                2330                2335    
Pro Gln Thr Asp Thr Glu Gly Asp Pro Leu Met Asn Met Leu Met Lys
            2340                2345                2350        
Leu Gln Glu Ala Ala Asn Tyr Ser Ser Thr Gln Ser Cys Asp Ser Glu
        2355                2360                2365            
Ser Thr Ser His His Glu Asp Ile Leu Asp Ser Ser Leu Glu Ser Thr
    2370                2375                2380                
Leu
2385


<210> 7154
<211> 423
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 383
<223> Xaa = Any Amino Acid

<400> 7154
Met Ser Ile Lys Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Asp
 1               5                  10                  15      
Pro Trp Ala Phe Ser Ser Leu Ser Tyr Thr Ser Gly Pro Gly Ala Pro
            20                  25                  30          
Ile Ser Phe Ser Ser Phe Ser Arg Val Gly Ser Ser Ser Phe Arg Gly
        35                  40                  45              
Gly Gln Gly Gly Gly Tyr Ala Gly Ala Ser Gly Met Gly Gly Ile Thr
    50                  55                  60                  
Ile Ile Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Asn Leu Glu Val
65                  70                  75                  80  
Asp Pro Asn Ile Gln Ala Val His Thr Gln Glu Lys Glu Gln Val Lys
                85                  90                  95      
Thr Leu Asn Lys Phe Ala Ser Phe Ile Glu Lys Leu Glu Thr Leu Gly
            100                 105                 110         
Gln Glu Lys Leu Lys Leu Glu Ala Glu Phe Gly Asn Met Lys Gly Leu
        115                 120                 125             
Val Glu Asn Phe Lys Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr
    130                 135                 140                 
Glu Val Gly Asn Glu Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala
145                 150                 155                 160 
Tyr Met Asn Lys Val Glu Leu Glu Ser Cys Leu Glu Val Leu Thr Asp
                165                 170                 175     
Glu Ile Asn Phe Phe Ser Gln Leu Tyr Glu Glu Asp Ile Gln Glu Leu
            180                 185                 190         
Gln Ser Gln Ile Ser Asp Thr Phe Val Val Leu Ser Met Asp Asn Ser
        195                 200                 205             
Arg Thr Leu Asp Met Asp Ser Ile Ile Thr Glu Val Arg Ala Gln Tyr
    210                 215                 220                 
Glu Glu Ile Ala Asn Cys Ser Gln Ala Glu Ala Val Arg Pro Cys Thr
225                 230                 235                 240 
Arg Ser Ser Met Arg Ser Cys Arg Arg Trp Leu Gly Ser Thr Gly Val
                245                 250                 255     
Thr Cys Gly Val Arg Arg Gln Ile Ser Glu Met Asn Gly Asn Ile Ser
            260                 265                 270         
Arg Leu Gln Ala Glu Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu
        275                 280                 285             
Glu Ala Thr Leu Ala Asp Ala Glu Gln Cys Gly Glu Leu Ala Val Lys
    290                 295                 300                 
Asp Ala Asn Ala Lys Leu Ser Lys Leu Gly Gly Cys Pro Thr Ala Gly
305                 310                 315                 320 
Gln Ala Gly His Gly Thr Ala Ala Ala Tyr Gln Gly Leu Ile Asn Phe
                325                 330                 335     
Lys Leu Ala Leu Asp Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu
            340                 345                 350         
Gly Glu Glu Ser Arg Leu Glu Ser Gly Met Arg Asn Met Ser Ile His
        355                 360                 365             
Ser Lys Thr Thr Ser Gly Tyr Val Ser Gly Leu Ser Ser Ala Xaa Gly
    370                 375                 380                 
Gly Leu Thr Ser Tyr Cys Leu Ser Ser Ser Phe Gly Ser Gly Ala Gly
385                 390                 395                 400 
Ser Ser Ser Thr Lys Ala Val Val Val Lys Lys Leu Glu Thr Arg Asp
                405                 410                 415     
Gly Lys Leu Val Ser Glu Ser
            420             


<210> 7155
<211> 990
<212> PRT
<213> Homo sapiens

<400> 7155
Ala Asn Ser Phe Asp Asp Arg Phe Leu Val Thr Ala Gly Ala Asp Gly
 1               5                  10                  15      
Asn Ile Phe Val Phe Asn Ile Phe Ser Glu Phe Met Leu Arg Lys Asp
            20                  25                  30          
Met Lys Ala Lys Val Pro Ser Pro Arg Phe Gly Ile Glu Thr Glu Pro
        35                  40                  45              
Ile Pro Glu Asp Ile Glu Asp Pro Lys Ala Tyr Ser Ile Glu Asn Ala
    50                  55                  60                  
Arg Arg Lys Arg Glu His Asp Lys Leu Met Lys Glu Val Gly Glu Ile
65                  70                  75                  80  
Lys Ala Arg Lys Arg Glu Gln Ile Lys Ala Leu Arg Ser Glu Phe Cys
                85                  90                  95      
Asn Leu Leu Glu Met Asn Glu Lys Leu Pro Lys His Met Gln Phe Lys
            100                 105                 110         
Arg Thr Asp Phe Asp Val Asp Ser Gln Ile Arg Ala Glu Met His Arg
        115                 120                 125             
Lys Thr Ala Phe Lys Ile Gln Gln Val Glu Lys Glu Leu Ala Trp Glu
    130                 135                 140                 
Lys Glu Lys His Glu Leu Gly Leu Met Lys Leu Lys Asn Arg Phe Arg
145                 150                 155                 160 
Asp Pro Leu Glu Ser Asp Thr Ile Val Val His Ala Ile Leu Ser Asp
                165                 170                 175     
His Lys Ile Ser Ser Tyr Arg Leu Val Gln Pro Ser Lys Tyr Ser Lys
            180                 185                 190         
Phe Lys Arg Ala Ser Gln Ser Glu Arg Lys Pro Ser Lys Leu Asp Arg
        195                 200                 205             
Phe Glu Lys Glu Gly Pro Gly Arg Lys Asp Ser Gln Arg Asp Ala Gly
    210                 215                 220                 
Gly Ser Val Thr Ile Gln Glu Glu Ser Ile Ile Glu Lys Gly Lys Lys
225                 230                 235                 240 
Phe Arg Pro Lys Thr Leu Ser Glu Ile Ile Val Glu Asn Gln Ile Glu
                245                 250                 255     
Lys Thr Arg Lys Leu Ile Leu Lys Ala Glu Arg Ala Gln Leu Lys Ile
            260                 265                 270         
Gln Gln Arg Lys Lys Glu Trp Glu Glu Leu Tyr Lys Ser Lys Pro Gly
        275                 280                 285             
Asp Asp Tyr Glu Asp Pro Lys Asp Leu Gln Ala Ile Lys Glu Ala Gln
    290                 295                 300                 
Val Tyr Met Gly Asp Phe Asn Leu Lys Thr Ala Pro Asp Tyr Lys Ile
305                 310                 315                 320 
Pro Glu His Met Arg Ile Asn Ala Ala Lys Lys Glu Glu Glu Leu Gly
                325                 330                 335     
His Leu Asp Ser Leu Val His Gly Asn Lys Arg His Met Asn Lys Cys
            340                 345                 350         
Ile Leu Ser Leu Arg Asp Leu Lys Val Ala Val Val Glu Glu Ile Gln
        355                 360                 365             
Cys Leu Val Gln Glu Leu Lys Asn Ile Gln Ser Thr Leu His Ile Ser
    370                 375                 380                 
Lys His Ile Pro Ile Pro Lys Ile Pro Gln Ile His Pro Glu Glu Val
385                 390                 395                 400 
Pro Glu Lys Arg Phe Gln Tyr Asp Glu Glu Thr Leu Leu Asn Phe Lys
                405                 410                 415     
Gln Gln Gln Met Lys Ser Lys Asp Glu Lys Ser Pro Gly Val Glu Gln
            420                 425                 430         
Thr Gly Ser Gly Gly Pro Val Gly Gly Phe Leu Lys Leu Ser Ser Arg
        435                 440                 445             
Lys Asp Gly Asp Leu Thr Thr Arg Asp Ser Ile Ser Arg Ser Ser Lys
    450                 455                 460                 
Ala Ser Thr Phe Ser Leu Asp Ile Pro Lys Cys Leu Glu Phe Glu Lys
465                 470                 475                 480 
Ala Glu Pro Thr Asp Val Glu Leu Glu Ile Met Lys Arg Asp Glu Ile
                485                 490                 495     
Lys His Val Tyr Met Gln Gln Tyr Leu Val Asn Arg Ile Lys Glu Leu
            500                 505                 510         
Val Val Thr Phe Asp Ala Glu Leu Arg Leu Leu Arg His Gln Lys Leu
        515                 520                 525             
Lys Leu Asp Thr Gln Met Lys Leu Ser Asp Leu His His Val Thr Leu
    530                 535                 540                 
Phe Gln Glu Ile Leu Leu Leu Lys Asn Phe Glu Lys Gln Glu Asn Ile
545                 550                 555                 560 
Leu Gln Glu Arg Val Asn Ser Leu Asp Lys Glu Glu Gln Tyr Met Gln
                565                 570                 575     
Trp Lys Ile Asn Glu Thr Leu Lys Glu Met Glu Glu Lys Lys Asn Glu
            580                 585                 590         
Ile Thr Lys Leu Gln Glu Gln Glu Lys Ala Leu Tyr Ala Gly Phe Gln
        595                 600                 605             
Ala Ala Ile Gly Glu Asn Asn Lys Phe Ala Asn Phe Leu Met Lys Val
    610                 615                 620                 
Leu Lys Lys Lys Ile Lys Arg Val Lys Lys Lys Glu Val Glu Gly Asp
625                 630                 635                 640 
Ala Asp Glu Asp Glu Glu Ser Glu Glu Ser Ser Glu Glu Glu Ser Ser
                645                 650                 655     
Leu Glu Ser Asp Glu Asp Glu Ser Glu Ser Glu Asp Glu Val Phe Asp
            660                 665                 670         
Asp Ser Ile Cys Pro Thr Asn Cys Asp Val Ala Leu Phe Glu Leu Ala
        675                 680                 685             
Leu His Leu Arg Glu Lys Arg Leu Asp Ile Glu Glu Ala Leu Val Glu
    690                 695                 700                 
Glu Lys Lys Ile Val Asp Asn Leu Lys Lys Glu Tyr Asp Thr Leu Ser
705                 710                 715                 720 
Lys Lys Val Lys Ile Val Ala Thr Asn Leu Asn Ala Ala Glu Glu Ala
                725                 730                 735     
Leu Glu Ala Tyr Gln Arg Glu Lys Gln Gln Arg Leu Asn Glu Leu Leu
            740                 745                 750         
Val Val Ile Pro Leu Lys Pro His Gln Ile Glu Tyr Val Val Phe Gly
        755                 760                 765             
Glu Ile Pro Ser Asp Leu Ser Gly Thr Leu Val Phe Ser Asn His Ala
    770                 775                 780                 
Leu Arg Arg Leu Gln Glu Arg Ile Arg Glu Leu Gln Glu Glu Asn Ser
785                 790                 795                 800 
Lys Gln Gln Lys Leu Asn Lys Glu Trp Arg Glu Arg Arg Lys Gln Leu
                805                 810                 815     
Ile Arg Glu Lys Arg Glu Met Thr Lys Thr Ile His Lys Met Glu Glu
            820                 825                 830         
Thr Val Arg Gln Leu Met Ile Ser Lys Phe Gly Arg Val Val Asn Leu
        835                 840                 845             
Glu Ala Leu Gln Met Leu Ser Val Asn Thr Thr Leu Glu Glu Leu Lys
    850                 855                 860                 
Ile Arg Lys Leu Arg Lys Glu Leu Ala Asn Ala Lys Glu Met Lys Met
865                 870                 875                 880 
Trp Glu Glu Lys Ile Ala Gln Met Arg Trp Glu Leu Met Met Lys Thr
                885                 890                 895     
Lys Glu His Thr Arg Lys Leu Tyr Gln Met Asn Asp Leu Cys Ile Glu
            900                 905                 910         
Lys Lys Lys Leu Asp Ser Arg Leu Asn Thr Leu Gln Asn Gln Gln Gly
        915                 920                 925             
Asn Ala Phe Gln Gly Pro Arg Glu Ala Asp Val Val Ala Arg Glu Glu
    930                 935                 940                 
Val Thr Glu Leu Ile Gln Leu Gln Ala Glu Arg Ile Ser Ala Leu Lys
945                 950                 955                 960 
Glu Glu Ile Ala Leu Leu Arg Arg Lys Gly Gly Leu Ile Leu Pro Pro
                965                 970                 975     
Ile Gln Ser Pro Arg Glu Lys Glu Ile Gln Pro Ala Asp Leu
            980                 985                 990 


<210> 7156
<211> 4862
<212> PRT
<213> Homo sapiens

<400> 7156
Met Ala Thr Met Ile Pro Pro Val Lys Leu Lys Trp Leu Glu His Leu
 1               5                  10                  15      
Asn Ser Ser Trp Ile Thr Glu Asp Ser Glu Ser Ile Ala Thr Arg Glu
            20                  25                  30          
Gly Val Ala Val Leu Tyr Ser Lys Leu Val Ser Asn Lys Glu Val Val
        35                  40                  45              
Pro Leu Pro Gln Gln Val Leu Cys Leu Lys Gly Pro Gln Leu Pro Asp
    50                  55                  60                  
Phe Glu Arg Glu Ser Leu Ser Ser Asp Glu Gln Asp His Tyr Leu Asp
65                  70                  75                  80  
Ala Leu Leu Ser Ser Gln Leu Ala Leu Ala Lys Met Val Cys Ser Asp
                85                  90                  95      
Ser Pro Phe Ala Gly Ala Leu Arg Lys Arg Leu Leu Val Leu Gln Arg
            100                 105                 110         
Val Phe Tyr Ala Leu Ser Asn Lys Tyr His Asp Lys Gly Lys Val Lys
        115                 120                 125             
Gln Gln Gln His Ser Pro Glu Ser Ser Ser Gly Ser Ala Asp Val His
    130                 135                 140                 
Ser Val Ser Glu Arg Pro Arg Ser Ser Thr Asp Ala Leu Ile Glu Met
145                 150                 155                 160 
Gly Val Arg Thr Gly Leu Ser Leu Leu Phe Ala Leu Leu Arg Gln Ser
                165                 170                 175     
Trp Met Met Pro Val Ser Gly Pro Gly Leu Ser Leu Cys Asn Asp Val
            180                 185                 190         
Ile His Thr Ala Ile Glu Val Val Ser Ser Leu Pro Pro Leu Ser Leu
        195                 200                 205             
Ala Asn Glu Ser Lys Ile Pro Pro Met Gly Leu Asp Cys Leu Ser Gln
    210                 215                 220                 
Val Thr Thr Phe Leu Lys Gly Val Thr Ile Pro Asn Ser Gly Ala Asp
225                 230                 235                 240 
Thr Leu Gly Arg Arg Leu Ala Ser Glu Leu Leu Leu Gly Leu Ala Ala
                245                 250                 255     
Gln Arg Gly Ser Leu Arg Tyr Leu Leu Glu Trp Ile Glu Met Ala Leu
            260                 265                 270         
Gly Ala Ser Ala Val Val His Thr Met Glu Lys Gly Lys Leu Leu Ser
        275                 280                 285             
Ser Gln Glu Gly Met Ile Ser Phe Asp Cys Phe Met Thr Ile Leu Met
    290                 295                 300                 
Gln Met Arg Arg Ser Leu Gly Ser Ser Ala Asp Arg Ser Gln Trp Arg
305                 310                 315                 320 
Glu Pro Thr Arg Thr Ser Asp Gly Leu Cys Ser Leu Tyr Glu Ala Ala
                325                 330                 335     
Leu Cys Leu Phe Glu Glu Val Cys Arg Met Ala Ser Asp Tyr Ser Arg
            340                 345                 350         
Thr Cys Ala Ser Pro Asp Ser Ile Gln Thr Gly Asp Ala Pro Ile Val
        355                 360                 365             
Ser Glu Thr Cys Glu Val Tyr Val Trp Gly Ser Asn Ser Ser His Gln
    370                 375                 380                 
Leu Val Glu Gly Thr Gln Glu Lys Ile Leu Gln Pro Lys Leu Ala Pro
385                 390                 395                 400 
Ser Phe Ser Asp Ala Gln Thr Ile Glu Ala Gly Gln Tyr Cys Thr Phe
                405                 410                 415     
Val Ile Ser Thr Asp Gly Ser Val Arg Ala Cys Gly Lys Gly Ser Tyr
            420                 425                 430         
Gly Arg Leu Gly Leu Gly Asp Ser Asn Asn Gln Ser Thr Leu Lys Lys
        435                 440                 445             
Leu Thr Phe Glu Pro His Arg Ser Ile Lys Lys Val Ser Ser Ser Lys
    450                 455                 460                 
Gly Ser Asp Gly His Thr Leu Ala Phe Thr Thr Glu Gly Glu Val Phe
465                 470                 475                 480 
Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly His Gly Asn Ser Ser
                485                 490                 495     
Thr Gln Lys Tyr Pro Lys Leu Ile Gln Gly Pro Leu Gln Gly Lys Val
            500                 505                 510         
Val Val Cys Val Ser Ala Gly Tyr Arg His Ser Ala Ala Val Thr Glu
        515                 520                 525             
Asp Gly Glu Leu Tyr Thr Trp Gly Glu Gly Asp Phe Gly Arg Leu Gly
    530                 535                 540                 
His Gly Asp Ser Asn Ser Arg Asn Ile Pro Thr Leu Val Lys Asp Ile
545                 550                 555                 560 
Ser Asn Val Gly Glu Val Ser Cys Gly Ser Ser His Thr Ile Ala Leu
                565                 570                 575     
Ser Lys Asp Gly Arg Thr Val Trp Ser Phe Gly Gly Gly Asp Asn Gly
            580                 585                 590         
Lys Leu Gly His Gly Asp Thr Asn Arg Val Tyr Lys Pro Lys Val Ile
        595                 600                 605             
Glu Ala Leu Gln Gly Met Phe Ile Arg Lys Val Cys Ala Gly Ser Gln
    610                 615                 620                 
Ser Ser Leu Ala Leu Thr Ser Thr Gly Gln Val Tyr Ala Trp Gly Cys
625                 630                 635                 640 
Gly Ala Cys Leu Gly Cys Gly Ser Ser Glu Ala Thr Ala Leu Arg Pro
                645                 650                 655     
Lys Leu Ile Glu Glu Leu Ala Ala Thr Arg Ile Val Asp Val Ser Ile
            660                 665                 670         
Gly Asp Ser His Cys Leu Ala Leu Ser His Asp Asn Glu Val Tyr Ala
        675                 680                 685             
Trp Gly Asn Asn Ser Met Gly Gln Cys Gly Gln Gly Asn Ser Thr Gly
    690                 695                 700                 
Pro Ile Thr Lys Pro Lys Lys Val Ser Gly Leu Asp Gly Ile Ala Ile
705                 710                 715                 720 
Gln Gln Ile Ser Ala Gly Thr Ser His Ser Leu Ala Trp Thr Ala Leu
                725                 730                 735     
Pro Arg Asp Arg Gln Val Val Ala Trp His Arg Pro Tyr Cys Val Asp
            740                 745                 750         
Leu Glu Glu Ser Thr Phe Ser His Leu Arg Ser Phe Leu Glu Arg Tyr
        755                 760                 765             
Cys Asp Lys Ile Asn Ser Glu Ile Pro Pro Leu Pro Phe Pro Ser Ser
    770                 775                 780                 
Arg Glu His His Ser Phe Leu Lys Leu Cys Leu Lys Leu Leu Ser Asn
785                 790                 795                 800 
His Leu Ala Leu Ala Leu Ala Gly Gly Val Ala Thr Ser Ile Leu Gly
                805                 810                 815     
Arg Gln Ala Gly Pro Leu Arg Asn Leu Leu Phe Arg Leu Met Asp Ser
            820                 825                 830         
Thr Val Pro Asp Glu Ile Gln Glu Val Val Ile Glu Thr Leu Ser Val
        835                 840                 845             
Gly Ala Thr Met Leu Leu Pro Pro Leu Arg Glu Arg Met Glu Leu Leu
    850                 855                 860                 
His Ser Leu Leu Pro Gln Gly Pro Asp Arg Trp Glu Ser Leu Ser Lys
865                 870                 875                 880 
Gly Gln Arg Met Gln Leu Asp Ile Ile Leu Thr Ser Leu Gln Asp His
                885                 890                 895     
Thr His Val Ala Ser Leu Leu Gly Tyr Ser Ser Pro Ser Asp Ala Ala
            900                 905                 910         
Asp Leu Ser Ser Val Cys Thr Gly Tyr Gly Asn Leu Ser Asp Gln Pro
        915                 920                 925             
Tyr Gly Thr Gln Ser Cys His Pro Asp Thr His Leu Ala Glu Ile Leu
    930                 935                 940                 
Met Lys Thr Leu Leu Arg Asn Leu Gly Phe Tyr Thr Asp Gln Ala Phe
945                 950                 955                 960 
Gly Glu Leu Glu Lys Asn Ser Asp Lys Phe Leu Leu Gly Thr Ser Ser
                965                 970                 975     
Ser Glu Asn Ser Gln Pro Ala His Leu His Glu Leu Leu Cys Ser Leu
            980                 985                 990         
Gln Lys Gln Leu Leu Ala Phe Cys His Ile Asn Asn Ile Ser Glu Asn
        995                 1000                1005            
Ser Ser Ser Val Ala Leu Leu His Lys His Leu Gln Leu Leu Leu Pro
    1010                1015                1020                
His Ala Thr Asp Ile Tyr Ser Arg Ser Ala Asn Leu Leu Lys Glu Ser
1025                1030                1035                1040
Pro Trp Asn Gly Ser Val Gly Glu Lys Leu Arg Asp Val Ile Tyr Val
                1045                1050                1055    
Ser Ala Ala Gly Ser Met Leu Cys Gln Ile Val Asn Ser Leu Leu Leu
            1060                1065                1070        
Leu Pro Val Ser Val Ala Arg Pro Leu Leu Ser Tyr Leu Leu Asp Leu
        1075                1080                1085            
Leu Pro Pro Leu Asp Cys Leu Asn Arg Leu Leu Pro Ala Ala Asp Leu
    1090                1095                1100                
Leu Glu Asp Gln Glu Leu Gln Trp Pro Leu His Gly Gly Pro Glu Leu
1105                1110                1115                1120
Ile Asp Pro Ala Gly Leu Pro Leu Pro Gln Pro Ala Gln Ser Trp Val
                1125                1130                1135    
Trp Leu Val Asp Leu Glu Arg Thr Ile Ala Leu Leu Ile Gly Arg Cys
            1140                1145                1150        
Leu Gly Gly Met Leu Gln Gly Ser Pro Val Ser Pro Glu Glu Gln Asp
        1155                1160                1165            
Thr Ala Tyr Trp Met Lys Thr Pro Leu Phe Ser Asp Gly Val Glu Met
    1170                1175                1180                
Asp Thr Pro Gln Leu Asp Lys Cys Met Ser Cys Leu Leu Glu Val Ala
1185                1190                1195                1200
Leu Ser Gly Asn Glu Glu Gln Lys Pro Phe Asp Tyr Lys Leu Arg Pro
                1205                1210                1215    
Glu Ile Ala Val Tyr Val Asp Leu Ala Leu Gly Cys Ser Lys Glu Pro
            1220                1225                1230        
Ala Arg Ser Leu Trp Ile Ser Met Gln Asp Tyr Ala Val Ser Lys Asp
        1235                1240                1245            
Trp Asp Ser Ala Thr Leu Ser Asn Glu Ser Leu Leu Asp Thr Val Ser
    1250                1255                1260                
Arg Phe Val Leu Ala Ala Leu Leu Lys His Thr Asn Leu Leu Ser Gln
1265                1270                1275                1280
Ala Cys Gly Glu Ser Arg Gln Tyr Gln Pro Gly Lys His Leu Ser Glu
                1285                1290                1295    
Val Tyr Arg Cys Val Tyr Lys Val Arg Ser Arg Leu Leu Ala Cys Lys
            1300                1305                1310        
Asn Leu Glu Leu Ile Gln Thr Arg Ser Ser Ser Arg Asp Arg Trp Ile
        1315                1320                1325            
Ser Glu Asn Gln Asp Ser Ala Asp Val Asp Pro Gln Glu His Ser Phe
    1330                1335                1340                
Thr Arg Thr Ile Asp Glu Glu Ala Glu Met Glu Glu Gln Ala Glu Arg
1345                1350                1355                1360
Asp Arg Glu Glu Gly His Pro Glu Pro Glu Asp Glu Glu Glu Glu Arg
                1365                1370                1375    
Glu His Glu Val Met Thr Ala Gly Lys Ile Phe Gln Cys Phe Leu Ser
            1380                1385                1390        
Ala Arg Glu Val Ala Arg Ser Arg Asp Arg Asp Arg Met Asn Ser Gly
        1395                1400                1405            
Ala Gly Ser Gly Ala Arg Ala Asp Asp Pro Pro Pro Gln Ser Gln Gln
    1410                1415                1420                
Glu Arg Arg Val Ser Thr Asp Leu Pro Glu Gly Gln Asp Val Tyr Thr
1425                1430                1435                1440
Ala Ala Cys Asn Ser Val Ile His Arg Cys Ala Leu Leu Ile Leu Gly
                1445                1450                1455    
Val Ser Pro Val Ile Asp Glu Leu Gln Lys Arg Arg Glu Glu Gly Gln
            1460                1465                1470        
Leu Gln Gln Pro Ser Thr Ser Ala Ser Glu Gly Gly Gly Leu Met Thr
        1475                1480                1485            
Arg Ser Glu Ser Leu Thr Ala Glu Ser Arg Leu Val His Thr Ser Pro
    1490                1495                1500                
Asn Tyr Arg Leu Ile Lys Ser Arg Ser Glu Ser Asp Leu Ser Gln Pro
1505                1510                1515                1520
Glu Ser Asp Glu Glu Gly Tyr Ala Leu Ser Gly Arg Arg Asn Val Asp
                1525                1530                1535    
Leu Asp Leu Ala Ala Ser His Arg Lys Arg Gly Pro Met His Ser Gln
            1540                1545                1550        
Leu Glu Ser Leu Ser Asp Ser Trp Ala Arg Leu Lys His Ser Arg Asp
        1555                1560                1565            
Trp Leu Cys Asn Ser Ser Tyr Ser Phe Glu Ser Asp Phe Asp Leu Thr
    1570                1575                1580                
Lys Ser Leu Gly Val His Thr Leu Ile Glu Asn Val Val Ser Phe Val
1585                1590                1595                1600
Ser Gly Asp Val Gly Asn Ala Pro Gly Phe Lys Glu Pro Glu Glu Ser
                1605                1610                1615    
Met Ser Thr Ser Pro Gln Ala Ser Ile Ile Ala Met Glu Gln Gln Gln
            1620                1625                1630        
Leu Arg Ala Glu Leu Arg Leu Glu Ala Leu His Gln Ile Leu Val Leu
        1635                1640                1645            
Leu Ser Gly Met Glu Glu Lys Gly Ser Ile Ser Leu Ala Gly Ser Arg
    1650                1655                1660                
Leu Ser Ser Gly Phe Gln Ser Ser Thr Leu Leu Thr Ser Val Arg Leu
1665                1670                1675                1680
Gln Phe Leu Ala Gly Cys Phe Gly Leu Gly Thr Val Gly His Thr Gly
                1685                1690                1695    
Gly Lys Gly Glu Ser Gly Arg Leu His His Tyr Gln Asp Gly Ile Arg
            1700                1705                1710        
Ala Ala Lys Arg Asn Ile Gln Ile Glu Ile Gln Val Ala Val His Lys
        1715                1720                1725            
Ile Tyr Gln Gln Leu Ser Ala Thr Leu Glu Arg Ala Leu Gln Ala Asn
    1730                1735                1740                
Lys His His Ile Glu Ala Gln Gln Arg Leu Leu Leu Val Thr Val Phe
1745                1750                1755                1760
Ala Leu Ser Val His Tyr Gln Pro Val Asp Val Ser Leu Ala Ile Ser
                1765                1770                1775    
Thr Gly Leu Leu Asn Val Leu Ser Gln Leu Cys Gly Thr Asp Thr Met
            1780                1785                1790        
Leu Gly Gln Pro Leu Gln Leu Leu Pro Lys Thr Gly Val Ser Gln Leu
        1795                1800                1805            
Ser Thr Ala Leu Lys Val Ala Ser Thr Arg Leu Leu Gln Ile Leu Ala
    1810                1815                1820                
Ile Thr Thr Gly Thr Tyr Ala Asp Lys Leu Ser Pro Lys Val Val Gln
1825                1830                1835                1840
Ser Leu Leu Asp Leu Leu Cys Ser Gln Leu Lys Asn Leu Leu Ser Gln
                1845                1850                1855    
Thr Gly Val Leu His Met Ala Ser Phe Gly Glu Gly Glu Gln Glu Asp
            1860                1865                1870        
Gly Glu Glu Glu Glu Lys Lys Val Asp Ser Ser Gly Glu Thr Glu Lys
        1875                1880                1885            
Lys Asp Phe Arg Ala Ala Leu Arg Lys Gln His Ala Ala Glu Leu His
    1890                1895                1900                
Leu Gly Asp Phe Leu Val Phe Leu Arg Arg Val Val Ser Ser Lys Ala
1905                1910                1915                1920
Ile Gln Ser Lys Met Ala Ser Pro Lys Trp Thr Glu Val Leu Leu Asn
                1925                1930                1935    
Ile Ala Ser Gln Lys Cys Ser Ser Gly Ile Pro Leu Val Gly Asn Leu
            1940                1945                1950        
Arg Thr Arg Leu Leu Ala Leu His Val Leu Glu Ala Val Leu Pro Ala
        1955                1960                1965            
Cys Glu Ser Gly Val Glu Asp Asp Gln Met Ala Gln Ile Val Glu Arg
    1970                1975                1980                
Leu Phe Ser Leu Leu Ser Asp Cys Met Trp Glu Thr Pro Ile Ala Gln
1985                1990                1995                2000
Ala Lys His Ala Ile Gln Ile Lys Glu Lys Glu Gln Glu Ile Lys Leu
                2005                2010                2015    
Gln Lys Gln Gly Glu Leu Glu Glu Glu Asp Glu Asn Leu Pro Ile Gln
            2020                2025                2030        
Glu Val Ser Phe Asp Pro Glu Lys Ala Gln Cys Cys Leu Val Glu Asn
        2035                2040                2045            
Gly Gln Ile Leu Thr His Gly Ser Gly Gly Lys Gly Tyr Gly Leu Ala
    2050                2055                2060                
Ser Thr Gly Val Thr Ser Gly Cys Tyr Gln Trp Lys Phe Tyr Ile Val
2065                2070                2075                2080
Lys Glu Asn Arg Gly Asn Glu Gly Thr Cys Val Gly Val Ser Arg Trp
                2085                2090                2095    
Pro Val His Asp Phe Asn His Arg Thr Thr Ser Asp Met Trp Leu Tyr
            2100                2105                2110        
Arg Ala Tyr Ser Gly Asn Leu Tyr His Asn Gly Glu Gln Thr Leu Thr
        2115                2120                2125            
Leu Ser Ser Phe Thr Gln Gly Asp Phe Ile Thr Cys Val Leu Asp Met
    2130                2135                2140                
Glu Ala Arg Thr Ile Ser Phe Gly Lys Asn Gly Glu Glu Pro Lys Leu
2145                2150                2155                2160
Ala Phe Glu Asp Val Asp Ala Ala Glu Leu Tyr Pro Cys Val Met Phe
                2165                2170                2175    
Tyr Ser Ser Asn Pro Gly Glu Lys Val Lys Ile Cys Asp Met Gln Met
            2180                2185                2190        
Arg Gly Thr Pro Arg Asp Leu Leu Pro Gly Asp Pro Ile Cys Ser Pro
        2195                2200                2205            
Val Ala Ala Val Leu Ala Glu Ala Thr Ile Gln Leu Ile Arg Ile Leu
    2210                2215                2220                
His Arg Thr Asp Arg Trp Thr Tyr Cys Ile Asn Lys Lys Met Met Glu
2225                2230                2235                2240
Arg Leu His Lys Ile Lys Ile Cys Ile Lys Glu Ser Gly Gln Lys Leu
                2245                2250                2255    
Lys Lys Ser Arg Ser Val Gln Ser Arg Glu Glu Asn Glu Met Arg Glu
            2260                2265                2270        
Glu Lys Glu Ser Lys Glu Glu Glu Lys Gly Lys His Thr Arg His Gly
        2275                2280                2285            
Leu Ala Asp Leu Ser Glu Leu Gln Leu Arg Thr Leu Cys Ile Glu Val
    2290                2295                2300                
Trp Pro Val Leu Ala Val Ile Gly Gly Val Asp Ala Gly Leu Arg Val
2305                2310                2315                2320
Gly Gly Arg Cys Val His Lys Gln Thr Gly Arg His Ala Thr Leu Leu
                2325                2330                2335    
Gly Val Val Lys Glu Gly Ser Thr Ser Ala Lys Val Gln Trp Asp Glu
            2340                2345                2350        
Ala Glu Ile Thr Ile Ser Phe Pro Thr Phe Trp Ser Pro Ser Asp Thr
        2355                2360                2365            
Pro Leu Tyr Asn Leu Glu Pro Cys Glu Pro Leu Pro Phe Asp Val Ala
    2370                2375                2380                
Arg Phe Arg Gly Leu Thr Ala Ser Val Leu Leu Asp Leu Thr Tyr Leu
2385                2390                2395                2400
Thr Gly Val His Glu Asp Met Gly Lys Gln Ser Thr Lys Arg His Glu
                2405                2410                2415    
Lys Lys His Arg His Glu Ser Glu Glu Lys Gly Asp Val Glu Gln Lys
            2420                2425                2430        
Pro Glu Ser Glu Ser Ala Leu Asp Met Arg Thr Gly Leu Thr Ser Asp
        2435                2440                2445            
Asp Val Lys Ser Gln Ser Thr Thr Ser Ser Lys Ser Glu Asn Glu Ile
    2450                2455                2460                
Ala Ser Phe Ser Leu Asp Pro Thr Leu Pro Ser Val Glu Ser Gln His
2465                2470                2475                2480
Gln Ile Thr Glu Gly Lys Arg Lys Asn His Glu His Met Ser Lys Asn
                2485                2490                2495    
His Asp Val Ala Gln Ser Glu Ile Arg Ala Val Gln Leu Ser Tyr Leu
            2500                2505                2510        
Tyr Leu Gly Ala Met Lys Ser Leu Ser Ala Leu Leu Gly Cys Ser Lys
        2515                2520                2525            
Tyr Ala Glu Leu Leu Leu Ile Pro Lys Val Leu Ala Glu Asn Gly His
    2530                2535                2540                
Asn Ser Asp Cys Ala Ser Ser Pro Val Val His Glu Asp Val Glu Met
2545                2550                2555                2560
Arg Ala Ala Leu Gln Phe Leu Met Arg His Met Val Lys Arg Ala Val
                2565                2570                2575    
Met Arg Ser Pro Ile Lys Arg Ala Leu Gly Leu Ala Asp Leu Glu Arg
            2580                2585                2590        
Ala Gln Ala Met Ile Tyr Lys Leu Val Val His Gly Leu Leu Glu Asp
        2595                2600                2605            
Gln Phe Gly Gly Lys Ile Lys Gln Glu Ile Asp Gln Gln Ala Glu Glu
    2610                2615                2620                
Ser Asp Pro Ala Gln Gln Ala Gln Thr Pro Val Thr Thr Ser Pro Ser
2625                2630                2635                2640
Ala Ser Ser Thr Thr Ser Phe Met Ser Ser Ser Leu Glu Asp Thr Thr
                2645                2650                2655    
Thr Ala Thr Thr Pro Val Thr Asp Thr Glu Thr Val Pro Ala Ser Glu
            2660                2665                2670        
Ser Pro Gly Val Met Pro Leu Ser Leu Leu Arg Gln Met Phe Ser Ser
        2675                2680                2685            
Tyr Pro Thr Thr Thr Val Leu Pro Thr Arg Arg Ala Gln Thr Pro Pro
    2690                2695                2700                
Ile Ser Ser Leu Pro Thr Ser Pro Ser Asp Glu Val Gly Arg Arg Gln
2705                2710                2715                2720
Ser Leu Thr Ser Pro Asp Ser Gln Ser Ala Arg Pro Ala Asn Arg Thr
                2725                2730                2735    
Ala Leu Ser Asp Pro Ser Ser Arg Leu Ser Thr Ser Pro Pro Pro Pro
            2740                2745                2750        
Ala Ile Ala Val Pro Leu Leu Glu Met Gly Phe Ser Leu Arg Gln Ile
        2755                2760                2765            
Ala Lys Ala Met Glu Ala Thr Gly Ala Arg Gly Glu Ala Asp Ala Gln
    2770                2775                2780                
Asn Ile Thr Val Leu Ala Met Trp Met Ile Glu His Pro Gly His Glu
2785                2790                2795                2800
Asp Glu Glu Glu Pro Gln Ser Gly Ser Thr Ala Asp Ser Arg Pro Gly
                2805                2810                2815    
Ala Ala Val Leu Gly Ser Gly Gly Lys Ser Asn Asp Pro Cys Tyr Leu
            2820                2825                2830        
Gln Ser Pro Gly Asp Ile Pro Ser Ala Asp Ala Ala Glu Met Glu Glu
        2835                2840                2845            
Gly Phe Ser Glu Ser Pro Asp Asn Leu Asp His Thr Glu Asn Ala Ala
    2850                2855                2860                
Ser Gly Ser Gly Pro Ser Ala Arg Gly Arg Ser Ala Val Thr Arg Arg
2865                2870                2875                2880
His Lys Phe Asp Leu Ala Ala Arg Thr Leu Leu Ala Arg Ala Ala Gly
                2885                2890                2895    
Leu Tyr Arg Ser Val Gln Ala His Arg Asn Gln Ser Arg Arg Glu Gly
            2900                2905                2910        
Ile Ser Leu Gln Gln Asp Pro Gly Ala Leu Tyr Asp Phe Asn Leu Asp
        2915                2920                2925            
Glu Glu Leu Glu Ile Asp Leu Asp Asp Glu Ala Met Glu Ala Met Phe
    2930                2935                2940                
Gly Gln Asp Leu Thr Ser Asp Asn Asp Ile Leu Gly Met Trp Ile Pro
2945                2950                2955                2960
Glu Val Leu Asp Trp Pro Thr Trp His Val Cys Glu Ser Glu Asp Arg
                2965                2970                2975    
Glu Glu Val Val Val Cys Glu Leu Cys Glu Cys Ser Val Val Ser Phe
            2980                2985                2990        
Asn Gln His Met Lys Arg Asn His Pro Gly Cys Gly Arg Ser Ala Asn
        2995                3000                3005            
Arg Gln Gly Tyr Arg Ser Asn Gly Ser Tyr Val Asp Gly Trp Phe Gly
    3010                3015                3020                
Gly Glu Cys Gly Ser Gly Asn Pro Tyr Tyr Leu Leu Cys Gly Thr Cys
3025                3030                3035                3040
Arg Glu Lys Tyr Leu Ala Met Lys Thr Lys Ser Lys Ser Thr Ser Ser
                3045                3050                3055    
Glu Arg Tyr Lys Gly Gln Ala Pro Asp Leu Ile Gly Lys Gln Asp Ser
            3060                3065                3070        
Val Tyr Glu Glu Asp Trp Asp Met Leu Asp Val Asp Glu Asp Glu Lys
        3075                3080                3085            
Leu Thr Gly Glu Glu Glu Phe Glu Leu Leu Ala Gly Pro Leu Gly Leu
    3090                3095                3100                
Asn Asp Arg Arg Ile Val Pro Glu Pro Val Gln Phe Pro Asp Ser Asp
3105                3110                3115                3120
Pro Leu Gly Ala Ser Val Ala Met Val Thr Ala Thr Asn Ser Met Glu
                3125                3130                3135    
Glu Thr Leu Met Gln Ile Gly Cys His Gly Ser Val Glu Lys Ser Ser
            3140                3145                3150        
Ser Gly Arg Ile Thr Leu Gly Glu Gln Ala Ala Ala Leu Ala Asn Pro
        3155                3160                3165            
His Asp Arg Val Val Ala Leu Arg Arg Val Thr Ala Ala Ala Gln Val
    3170                3175                3180                
Leu Leu Ala Arg Thr Met Val Met Arg Ala Leu Ser Leu Leu Ser Val
3185                3190                3195                3200
Ser Gly Ser Ser Cys Ser Leu Ala Ala Gly Leu Glu Ser Leu Gly Leu
                3205                3210                3215    
Thr Asp Ile Arg Thr Leu Val Arg Leu Met Cys Leu Ala Ala Ala Gly
            3220                3225                3230        
Arg Ala Gly Leu Ser Thr Ser Pro Ser Ala Met Ala Ser Thr Ser Glu
        3235                3240                3245            
Arg Ser Arg Gly Gly His Ser Lys Ala Asn Lys Pro Ile Ser Cys Leu
    3250                3255                3260                
Ala Tyr Leu Ser Thr Ala Val Gly Cys Leu Ala Ser Asn Ala Pro Ser
3265                3270                3275                3280
Ala Ala Lys Leu Leu Val Gln Leu Cys Thr Gln Asn Leu Ile Ser Ala
                3285                3290                3295    
Ala Thr Gly Val Asn Leu Thr Thr Val Asp Asp Ser Ile Gln Arg Lys
            3300                3305                3310        
Phe Leu Pro Ser Phe Leu Arg Gly Ile Ala Glu Glu Asn Lys Leu Val
        3315                3320                3325            
Thr Ser Pro Asn Phe Val Val Thr Gln Ala Leu Val Ala Leu Leu Ala
    3330                3335                3340                
Asp Lys Gly Ala Lys Leu Arg Pro Asn Tyr Asp Lys Ser Glu Val Glu
3345                3350                3355                3360
Lys Lys Gly Pro Leu Glu Leu Ala Asn Ala Leu Ala Ala Cys Cys Leu
                3365                3370                3375    
Ser Ser Arg Leu Ser Ser Gln His Arg Gln Trp Ala Ala Gln Gln Leu
            3380                3385                3390        
Val Arg Thr Leu Ala Ala His Asp Arg Asp Asn Gln Thr Thr Leu Gln
        3395                3400                3405            
Thr Leu Ala Asp Met Gly Gly Asp Leu Arg Lys Cys Ser Phe Ile Lys
    3410                3415                3420                
Leu Glu Ala His Gln Asn Arg Val Met Thr Cys Val Trp Cys Asn Lys
3425                3430                3435                3440
Lys Gly Leu Leu Ala Thr Ser Gly Asn Asp Gly Thr Ile Arg Val Trp
                3445                3450                3455    
Asn Val Thr Lys Lys Gln Tyr Ser Leu Gln Gln Thr Cys Val Phe Asn
            3460                3465                3470        
Arg Leu Glu Gly Asp Ala Glu Glu Ser Leu Gly Ser Pro Ser Asp Pro
        3475                3480                3485            
Ser Phe Ser Pro Val Ser Trp Ser Ile Ser Gly Lys Tyr Leu Ala Gly
    3490                3495                3500                
Ala Leu Glu Lys Met Val Asn Ile Trp Gln Val Asn Gly Gly Lys Gly
3505                3510                3515                3520
Leu Val Asp Ile Gln Pro His Trp Val Ser Ala Leu Ala Trp Pro Glu
                3525                3530                3535    
Glu Gly Pro Ala Thr Ala Trp Ser Gly Glu Ser Pro Glu Leu Leu Leu
            3540                3545                3550        
Val Gly Arg Met Asp Gly Ser Leu Gly Leu Ile Glu Val Val Asp Val
        3555                3560                3565            
Ser Thr Met His Arg Arg Glu Leu Glu His Cys Tyr Arg Lys Asp Val
    3570                3575                3580                
Ser Val Thr Cys Ile Ala Trp Phe Ser Glu Asp Arg Pro Phe Ala Val
3585                3590                3595                3600
Gly Tyr Phe Asp Gly Lys Leu Leu Leu Gly Thr Lys Glu Pro Leu Glu
                3605                3610                3615    
Lys Gly Gly Ile Val Leu Ile Asp Ala His Lys Asp Thr Leu Ile Ser
            3620                3625                3630        
Met Lys Trp Asp Pro Thr Gly His Ile Leu Met Thr Cys Ala Lys Glu
        3635                3640                3645            
Asp Ser Val Lys Leu Trp Gly Ser Ile Ser Gly Cys Trp Cys Cys Leu
    3650                3655                3660                
His Ser Leu Cys His Pro Ser Ile Val Asn Gly Ile Ala Trp Cys Arg
3665                3670                3675                3680
Leu Pro Gly Lys Gly Ser Lys Leu Gln Leu Leu Met Ala Thr Gly Cys
                3685                3690                3695    
Gln Ser Gly Leu Val Cys Val Trp Arg Ile Pro Gln Asp Thr Thr Gln
            3700                3705                3710        
Thr Asn Val Thr Ser Ala Glu Gly Trp Trp Glu Gln Glu Ser Asn Cys
        3715                3720                3725            
Gln Asp Gly Tyr Arg Lys Ser Ser Gly Ala Lys Cys Val Tyr Gln Leu
    3730                3735                3740                
Arg Gly His Ile Thr Pro Val Arg Thr Val Ala Phe Ser Ser Asp Gly
3745                3750                3755                3760
Leu Ala Leu Val Ser Gly Gly Leu Gly Gly Leu Met Asn Ile Trp Ser
                3765                3770                3775    
Leu Arg Asp Gly Ser Val Leu Gln Thr Val Val Ile Gly Ser Gly Ala
            3780                3785                3790        
Ile Gln Thr Thr Val Trp Ile Pro Glu Val Gly Val Ala Ala Cys Ser
        3795                3800                3805            
Asn Arg Ser Lys Asp Val Leu Val Val Asn Cys Thr Ala Glu Trp Ala
    3810                3815                3820                
Ala Ala Asn His Val Leu Ala Thr Cys Arg Thr Ala Leu Lys Gln Gln
3825                3830                3835                3840
Gly Val Leu Gly Leu Asn Met Ala Pro Cys Met Arg Ala Phe Leu Glu
                3845                3850                3855    
Arg Leu Pro Met Met Leu Gln Glu Gln Tyr Ala Tyr Glu Lys Pro His
            3860                3865                3870        
Val Val Cys Gly Asp Gln Leu Val His Ser Pro Tyr Met Gln Cys Leu
        3875                3880                3885            
Ala Ser Leu Ala Val Gly Leu His Leu Asp Gln Leu Leu Cys Asn Pro
    3890                3895                3900                
Pro Val Pro Pro His His Gln Asn Cys Leu Pro Asp Pro Ala Ser Trp
3905                3910                3915                3920
Asn Pro Asn Glu Trp Ala Trp Leu Glu Cys Phe Ser Thr Thr Ile Lys
                3925                3930                3935    
Ala Ala Glu Ala Leu Thr Asn Gly Ala Gln Phe Pro Glu Ser Phe Thr
            3940                3945                3950        
Val Pro Asp Leu Glu Pro Val Pro Glu Asp Glu Leu Val Phe Leu Met
        3955                3960                3965            
Asp Asn Ser Lys Trp Ile Asn Gly Met Asp Glu Gln Ile Met Ser Trp
    3970                3975                3980                
Ala Thr Ser Arg Pro Glu Asp Trp His Leu Gly Gly Lys Cys Asp Val
3985                3990                3995                4000
Tyr Leu Trp Gly Ala Gly Arg His Gly Gln Leu Ala Glu Ala Gly Arg
                4005                4010                4015    
Asn Val Met Val Pro Ala Ala Ala Pro Ser Phe Ser Gln Ala Gln Gln
            4020                4025                4030        
Val Ile Cys Gly Gln Asn Cys Thr Phe Val Ile Gln Ala Asn Gly Thr
        4035                4040                4045            
Val Leu Ala Cys Gly Glu Gly Ser Tyr Gly Arg Leu Gly Gln Gly Asn
    4050                4055                4060                
Ser Asp Asp Leu His Val Leu Thr Val Ile Ser Ala Leu Gln Gly Phe
4065                4070                4075                4080
Val Val Thr Gln Leu Val Thr Ser Cys Gly Ser Asp Gly His Ser Met
                4085                4090                4095    
Ala Leu Thr Glu Ser Gly Glu Val Phe Ser Trp Gly Asp Gly Asp Tyr
            4100                4105                4110        
Gly Lys Leu Gly His Gly Asn Ser Asp Arg Gln Arg Arg Pro Arg Gln
        4115                4120                4125            
Ile Glu Ala Leu Gln Gly Glu Glu Val Val Gln Met Ser Cys Gly Phe
    4130                4135                4140                
Lys His Ser Ala Val Val Thr Ser Asp Gly Lys Leu Phe Thr Phe Gly
4145                4150                4155                4160
Asn Gly Asp Tyr Gly Arg Leu Gly Leu Gly Asn Thr Ser Asn Lys Lys
                4165                4170                4175    
Leu Pro Glu Arg Val Thr Ala Leu Glu Gly Tyr Gln Ile Gly Gln Val
            4180                4185                4190        
Ala Cys Gly Leu Asn His Thr Leu Ala Val Ser Ala Asp Gly Ser Met
        4195                4200                4205            
Val Trp Ala Phe Gly Asp Gly Asp Tyr Gly Lys Leu Gly Leu Gly Asn
    4210                4215                4220                
Ser Thr Ala Lys Ser Ser Pro Gln Lys Ile Asp Val Leu Cys Gly Ile
4225                4230                4235                4240
Gly Ile Lys Lys Val Ala Cys Gly Thr Gln Phe Ser Val Ala Leu Thr
                4245                4250                4255    
Lys Asp Gly His Val Tyr Thr Phe Gly Gln Asp Arg Leu Ile Gly Leu
            4260                4265                4270        
Pro Glu Gly Arg Ala Arg Asn His Asn Arg Pro Gln Gln Ile Pro Val
        4275                4280                4285            
Leu Ala Gly Val Ile Ile Glu Asp Val Ala Val Gly Ala Glu His Thr
    4290                4295                4300                
Leu Ala Leu Ala Ser Asn Gly Asp Val Tyr Ala Trp Gly Ser Asn Ser
4305                4310                4315                4320
Glu Gly Gln Leu Gly Leu Gly His Thr Asn His Val Arg Glu Pro Thr
                4325                4330                4335    
Leu Val Thr Gly Leu Gln Gly Lys Asn Val Arg Gln Ile Ser Ala Gly
            4340                4345                4350        
Arg Cys His Ser Ala Ala Trp Thr Ala Pro Pro Val Pro Pro Arg Ala
        4355                4360                4365            
Pro Gly Val Ser Val Pro Leu Gln Leu Gly Leu Pro Asp Thr Val Pro
    4370                4375                4380                
Pro Gln Tyr Gly Ala Leu Arg Glu Val Ser Ile His Thr Val Arg Ala
4385                4390                4395                4400
Arg Leu Arg Leu Leu Tyr His Phe Ser Asp Leu Met Tyr Ser Ser Trp
                4405                4410                4415    
Arg Leu Leu Asn Leu Ser Pro Asn Asn Gln Asn Ser Thr Ser His Tyr
            4420                4425                4430        
Asn Ala Gly Thr Trp Gly Ile Val Gln Gly Gln Leu Arg Pro Leu Leu
        4435                4440                4445            
Ala Pro Arg Val Tyr Thr Leu Pro Met Val Arg Ser Ile Gly Lys Thr
    4450                4455                4460                
Met Val Gln Gly Lys Asn Tyr Gly Pro Gln Ile Thr Val Lys Arg Ile
4465                4470                4475                4480
Ser Thr Arg Gly Arg Lys Cys Lys Pro Ile Phe Val Gln Ile Ala Arg
                4485                4490                4495    
Gln Val Val Lys Leu Asn Ala Ser Asp Leu Arg Leu Pro Ser Arg Ala
            4500                4505                4510        
Trp Lys Val Lys Leu Val Gly Glu Gly Ala Asp Asp Ala Gly Gly Val
        4515                4520                4525            
Phe Asp Asp Thr Ile Thr Glu Met Cys Gln Glu Leu Glu Thr Gly Ile
    4530                4535                4540                
Val Asp Leu Leu Ile Pro Ser Pro Asn Ala Thr Ala Glu Val Gly Tyr
4545                4550                4555                4560
Asn Arg Asp Arg Phe Leu Phe Asn Pro Ser Ala Cys Leu Asp Glu His
                4565                4570                4575    
Leu Met Gln Phe Lys Phe Leu Gly Ile Leu Met Gly Val Ala Ile Arg
            4580                4585                4590        
Thr Lys Lys Pro Leu Asp Leu His Leu Ala Pro Leu Val Trp Lys Gln
        4595                4600                4605            
Leu Cys Cys Val Pro Leu Thr Leu Glu Asp Leu Glu Glu Val Asp Leu
    4610                4615                4620                
Leu Tyr Val Gln Thr Leu Asn Ser Ile Leu His Ile Glu Asp Ser Gly
4625                4630                4635                4640
Ile Thr Glu Glu Ser Phe His Glu Met Ile Pro Leu Asp Ser Phe Val
                4645                4650                4655    
Gly Gln Ser Ala Asp Gly Lys Met Val Pro Ile Ile Pro Gly Gly Asn
            4660                4665                4670        
Ser Ile Pro Leu Thr Phe Ser Asn Arg Lys Glu Tyr Val Glu Arg Ala
        4675                4680                4685            
Ile Glu Tyr Arg Leu His Glu Met Asp Arg Gln Val Ala Ala Val Arg
    4690                4695                4700                
Glu Gly Met Ser Trp Ile Val Pro Val Pro Leu Leu Ser Leu Leu Thr
4705                4710                4715                4720
Ala Lys Gln Leu Glu Gln Met Val Cys Gly Met Pro Glu Ile Ser Val
                4725                4730                4735    
Glu Val Leu Lys Lys Val Val Arg Tyr Arg Glu Val Asp Glu Gln His
            4740                4745                4750        
Gln Leu Val Gln Trp Phe Trp His Thr Leu Glu Glu Phe Ser Asn Glu
        4755                4760                4765            
Glu Arg Val Leu Phe Met Arg Phe Val Ser Gly Arg Ser Arg Leu Pro
    4770                4775                4780                
Ala Asn Thr Ala Asp Ile Ser Gln Arg Phe Gln Ile Met Lys Val Asp
4785                4790                4795                4800
Arg Pro Tyr Asp Ser Leu Pro Thr Ser Gln Thr Cys Phe Phe Gln Leu
                4805                4810                4815    
Arg Leu Pro Pro Tyr Ser Ser Gln Leu Val Met Ala Glu Arg Leu Arg
            4820                4825                4830        
Tyr Ala Ile Asn Asn Cys Arg Ser Ile Asp Met Asp Asn Tyr Met Leu
        4835                4840                4845            
Ser Arg Asn Val Asp Asn Ala Glu Gly Ser Asp Thr Asp Tyr
    4850                4855                4860        


<210> 7157
<211> 862
<212> PRT
<213> Homo sapiens

<400> 7157
Met Ser Asp Ser Gly Ser Gln Leu Gly Ser Met Gly Ser Leu Thr Met
 1               5                  10                  15      
Lys Ser Gln Leu Gln Ile Thr Val Ile Ser Ala Lys Leu Lys Glu Asn
            20                  25                  30          
Lys Lys Asn Trp Phe Gly Pro Ser Pro Tyr Val Glu Val Thr Val Asp
        35                  40                  45              
Gly Gln Ser Lys Lys Thr Glu Lys Cys Asn Asn Thr Asn Ser Pro Lys
    50                  55                  60                  
Trp Lys Gln Pro Leu Thr Val Ile Val Thr Pro Val Ser Lys Leu His
65                  70                  75                  80  
Phe Arg Val Trp Ser His Gln Thr Leu Lys Ser Asp Val Leu Leu Gly
                85                  90                  95      
Thr Ala Ala Leu Asp Ile Tyr Glu Thr Leu Lys Ser Asn Asn Met Lys
            100                 105                 110         
Leu Glu Glu Val Val Val Thr Leu Gln Leu Gly Gly Asp Lys Glu Pro
        115                 120                 125             
Thr Glu Thr Ile Gly Asp Leu Ser Ile Cys Leu Asp Gly Leu Gln Leu
    130                 135                 140                 
Glu Ser Glu Val Val Thr Asn Gly Glu Thr Thr Cys Ser Glu Ser Ala
145                 150                 155                 160 
Ser Gln Asn Asp Asp Gly Ser Arg Ser Lys Asp Glu Thr Arg Val Ser
                165                 170                 175     
Thr Asn Gly Ser Asp Asp Pro Glu Asp Ala Gly Ala Gly Glu Asn Arg
            180                 185                 190         
Arg Val Ser Gly Asn Asn Ser Pro Ser Leu Ser Asn Gly Gly Phe Lys
        195                 200                 205             
Pro Ser Arg Pro Pro Arg Pro Ser Arg Pro Pro Pro Pro Thr Pro Arg
    210                 215                 220                 
Arg Pro Ala Ser Val Asn Gly Ser Pro Ser Ala Thr Ser Glu Ser Asp
225                 230                 235                 240 
Gly Ser Ser Thr Gly Ser Leu Pro Pro Thr Asn Thr Asn Thr Asn Thr
                245                 250                 255     
Ser Glu Gly Ala Thr Ser Gly Leu Ile Ile Pro Leu Thr Ile Ser Gly
            260                 265                 270         
Gly Ser Gly Pro Arg Pro Leu Asn Pro Val Thr Gln Ala Pro Leu Pro
        275                 280                 285             
Pro Gly Trp Glu Gln Arg Val Asp Gln His Gly Arg Val Tyr Tyr Val
    290                 295                 300                 
Asp His Val Glu Lys Arg Thr Thr Trp Asp Arg Pro Glu Pro Leu Pro
305                 310                 315                 320 
Pro Gly Trp Glu Arg Arg Val Asp Asn Met Gly Arg Ile Tyr Tyr Val
                325                 330                 335     
Asp His Phe Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr Leu Glu Ser
            340                 345                 350         
Val Arg Asn Tyr Glu Gln Trp Gln Leu Gln Arg Ser Gln Leu Gln Gly
        355                 360                 365             
Ala Met Gln Gln Phe Asn Gln Arg Phe Ile Tyr Gly Asn Gln Asp Leu
    370                 375                 380                 
Phe Ala Thr Ser Gln Ser Lys Glu Phe Asp Pro Leu Gly Pro Leu Pro
385                 390                 395                 400 
Pro Gly Trp Glu Lys Arg Thr Asp Ser Asn Gly Arg Val Tyr Phe Val
                405                 410                 415     
Asn His Asn Thr Arg Ile Thr Gln Trp Glu Asp Pro Arg Ser Gln Gly
            420                 425                 430         
Gln Leu Asn Glu Lys Pro Leu Pro Glu Gly Trp Glu Met Arg Phe Thr
        435                 440                 445             
Val Asp Gly Ile Pro Tyr Phe Val Asp His Asn Arg Arg Thr Thr Thr
    450                 455                 460                 
Tyr Ile Asp Pro Arg Thr Gly Lys Ser Ala Leu Asp Asn Gly Pro Gln
465                 470                 475                 480 
Ile Ala Tyr Val Arg Asp Phe Lys Ala Lys Val Gln Tyr Phe Arg Phe
                485                 490                 495     
Trp Cys Gln Gln Leu Ala Met Pro Gln His Ile Lys Ile Thr Val Thr
            500                 505                 510         
Arg Lys Thr Leu Phe Glu Asp Ser Phe Gln Gln Ile Met Ser Phe Ser
        515                 520                 525             
Pro Gln Asp Leu Arg Arg Arg Leu Trp Val Ile Phe Pro Gly Glu Glu
    530                 535                 540                 
Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp Phe Phe Leu Leu Ser
545                 550                 555                 560 
His Glu Val Leu Asn Pro Met Tyr Cys Leu Phe Glu Tyr Ala Gly Lys
                565                 570                 575     
Asp Asn Tyr Cys Leu Gln Ile Asn Pro Ala Ser Tyr Ile Asn Pro Asp
            580                 585                 590         
His Leu Lys Tyr Phe Arg Phe Ile Gly Arg Phe Ile Ala Met Ala Leu
        595                 600                 605             
Phe His Gly Lys Phe Ile Asp Thr Gly Phe Ser Leu Pro Phe Tyr Lys
    610                 615                 620                 
Arg Ile Leu Asn Lys Pro Val Gly Leu Lys Asp Leu Glu Ser Ile Asp
625                 630                 635                 640 
Pro Glu Phe Tyr Asn Ser Leu Ile Trp Val Lys Glu Asn Asn Ile Glu
                645                 650                 655     
Glu Cys Asp Leu Glu Met Tyr Phe Ser Val Asp Lys Glu Ile Leu Gly
            660                 665                 670         
Glu Ile Lys Ser His Asp Leu Lys Pro Asn Gly Gly Asn Ile Leu Val
        675                 680                 685             
Thr Glu Glu Asn Lys Glu Glu Tyr Ile Arg Met Val Ala Glu Trp Arg
    690                 695                 700                 
Leu Ser Arg Gly Val Glu Glu Gln Thr Gln Ala Phe Phe Glu Gly Phe
705                 710                 715                 720 
Asn Glu Ile Leu Pro Gln Gln Tyr Leu Gln Tyr Phe Asp Ala Lys Glu
                725                 730                 735     
Leu Glu Val Leu Leu Cys Gly Met Gln Glu Ile Asp Leu Asn Asp Trp
            740                 745                 750         
Gln Arg His Ala Ile Tyr Arg His Tyr Ala Arg Thr Ser Lys Gln Ile
        755                 760                 765             
Met Trp Phe Trp Gln Phe Val Lys Glu Ile Asp Asn Glu Lys Arg Met
    770                 775                 780                 
Arg Leu Leu Gln Phe Val Thr Gly Thr Cys Arg Leu Pro Val Gly Gly
785                 790                 795                 800 
Phe Ala Asp Leu Met Gly Ser Asn Gly Pro Gln Lys Phe Cys Ile Glu
                805                 810                 815     
Lys Val Gly Lys Glu Asn Trp Leu Pro Arg Ser His Thr Cys Phe Asn
            820                 825                 830         
Arg Leu Asp Leu Pro Pro Tyr Lys Ser Tyr Glu Gln Leu Lys Glu Lys
        835                 840                 845             
Leu Leu Phe Ala Ile Glu Glu Thr Glu Gly Phe Gly Gln Glu
    850                 855                 860         


<210> 7158
<211> 903
<212> PRT
<213> Homo sapiens

<400> 7158
Met Ser Asp Ser Gly Ser Gln Leu Gly Ser Met Gly Ser Leu Thr Met
 1               5                  10                  15      
Lys Ser Gln Leu Gln Ile Thr Val Ile Ser Ala Lys Leu Lys Glu Asn
            20                  25                  30          
Lys Lys Asn Trp Phe Gly Pro Ser Pro Tyr Val Glu Val Thr Val Asp
        35                  40                  45              
Gly Gln Ser Lys Lys Thr Glu Lys Cys Asn Asn Thr Asn Ser Pro Lys
    50                  55                  60                  
Trp Lys Gln Pro Leu Thr Val Ile Val Thr Pro Val Ser Lys Leu His
65                  70                  75                  80  
Phe Arg Val Trp Ser His Gln Thr Leu Lys Ser Asp Val Leu Leu Gly
                85                  90                  95      
Thr Ala Ala Leu Asp Ile Tyr Glu Thr Leu Lys Ser Asn Asn Met Lys
            100                 105                 110         
Leu Glu Glu Val Val Val Thr Leu Gln Leu Gly Gly Asp Lys Glu Pro
        115                 120                 125             
Thr Glu Thr Ile Gly Asp Leu Ser Ile Cys Leu Asp Gly Leu Gln Leu
    130                 135                 140                 
Glu Ser Glu Val Val Thr Asn Gly Glu Thr Thr Cys Ser Glu Asn Gly
145                 150                 155                 160 
Val Ser Leu Cys Leu Pro Arg Leu Glu Cys Asn Ser Ala Ile Ser Ala
                165                 170                 175     
His Cys Asn Leu Cys Leu Pro Gly Leu Ser Asp Ser Pro Ile Ser Ala
            180                 185                 190         
Ser Arg Val Ala Gly Phe Thr Gly Ala Ser Gln Asn Asp Asp Gly Ser
        195                 200                 205             
Arg Ser Lys Asp Glu Thr Arg Val Ser Thr Asn Gly Ser Asp Asp Pro
    210                 215                 220                 
Glu Asp Ala Gly Ala Gly Glu Asn Arg Arg Val Ser Gly Asn Asn Ser
225                 230                 235                 240 
Pro Ser Leu Ser Asn Gly Gly Phe Lys Pro Ser Arg Pro Pro Arg Pro
                245                 250                 255     
Ser Arg Pro Pro Pro Pro Thr Pro Arg Arg Pro Ala Ser Val Asn Gly
            260                 265                 270         
Ser Pro Ser Ala Thr Ser Glu Ser Asp Gly Ser Ser Thr Gly Ser Leu
        275                 280                 285             
Pro Pro Thr Asn Thr Asn Thr Asn Thr Ser Glu Gly Ala Thr Ser Gly
    290                 295                 300                 
Leu Ile Ile Pro Leu Thr Ile Ser Gly Gly Ser Gly Pro Arg Pro Leu
305                 310                 315                 320 
Asn Pro Val Thr Gln Ala Pro Leu Pro Pro Gly Trp Glu Gln Arg Val
                325                 330                 335     
Asp Gln His Gly Arg Val Tyr Tyr Val Asp His Val Glu Lys Arg Thr
            340                 345                 350         
Thr Trp Asp Arg Pro Glu Pro Leu Pro Pro Gly Trp Glu Arg Arg Val
        355                 360                 365             
Asp Asn Met Gly Arg Ile Tyr Tyr Val Asp His Phe Thr Arg Thr Thr
    370                 375                 380                 
Thr Trp Gln Arg Pro Thr Leu Glu Ser Val Arg Asn Tyr Glu Gln Trp
385                 390                 395                 400 
Gln Leu Gln Arg Ser Gln Leu Gln Gly Ala Met Gln Gln Phe Asn Gln
                405                 410                 415     
Arg Phe Ile Tyr Gly Asn Gln Asp Leu Phe Ala Thr Ser Gln Ser Lys
            420                 425                 430         
Glu Phe Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr
        435                 440                 445             
Asp Ser Asn Gly Arg Val Tyr Phe Val Asn His Asn Thr Arg Ile Thr
    450                 455                 460                 
Gln Trp Glu Asp Pro Arg Ser Gln Gly Gln Leu Asn Glu Lys Pro Leu
465                 470                 475                 480 
Pro Glu Gly Trp Glu Met Arg Phe Thr Val Asp Gly Ile Pro Tyr Phe
                485                 490                 495     
Val Asp His Asn Arg Arg Thr Thr Thr Tyr Ile Asp Pro Arg Thr Gly
            500                 505                 510         
Lys Ser Ala Leu Asp Asn Gly Pro Gln Ile Ala Tyr Val Arg Asp Phe
        515                 520                 525             
Lys Ala Lys Val Gln Tyr Phe Arg Phe Trp Cys Gln Gln Leu Ala Met
    530                 535                 540                 
Pro Gln His Ile Lys Ile Thr Val Thr Arg Lys Thr Leu Phe Glu Asp
545                 550                 555                 560 
Ser Phe Gln Gln Ile Met Ser Phe Ser Pro Gln Asp Leu Arg Arg Arg
                565                 570                 575     
Leu Trp Val Ile Phe Pro Gly Glu Glu Gly Leu Asp Tyr Gly Gly Val
            580                 585                 590         
Ala Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met
        595                 600                 605             
Tyr Cys Leu Phe Glu Tyr Ala Gly Lys Asp Asn Tyr Cys Leu Gln Ile
    610                 615                 620                 
Asn Pro Ala Ser Tyr Ile Asn Pro Asp His Leu Lys Tyr Phe Arg Phe
625                 630                 635                 640 
Ile Gly Arg Phe Ile Ala Met Ala Leu Phe His Gly Lys Phe Ile Asp
                645                 650                 655     
Thr Gly Phe Ser Leu Pro Phe Tyr Lys Arg Ile Leu Asn Lys Pro Val
            660                 665                 670         
Gly Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Leu
        675                 680                 685             
Ile Trp Val Lys Glu Asn Asn Ile Glu Glu Cys Asp Leu Glu Met Tyr
    690                 695                 700                 
Phe Ser Val Asp Lys Glu Ile Leu Gly Glu Ile Lys Ser His Asp Leu
705                 710                 715                 720 
Lys Pro Asn Gly Gly Asn Ile Leu Val Thr Glu Glu Asn Lys Glu Glu
                725                 730                 735     
Tyr Ile Arg Met Val Ala Glu Trp Arg Leu Ser Arg Gly Val Glu Glu
            740                 745                 750         
Gln Thr Gln Ala Phe Phe Glu Gly Phe Asn Glu Ile Leu Pro Gln Gln
        755                 760                 765             
Tyr Leu Gln Tyr Phe Asp Ala Lys Glu Leu Glu Val Leu Leu Cys Gly
    770                 775                 780                 
Met Gln Glu Ile Asp Leu Asn Asp Trp Gln Arg His Ala Ile Tyr Arg
785                 790                 795                 800 
His Tyr Ala Arg Thr Ser Lys Gln Ile Met Trp Phe Trp Gln Phe Val
                805                 810                 815     
Lys Glu Ile Asp Asn Glu Lys Arg Met Arg Leu Leu Gln Phe Val Thr
            820                 825                 830         
Gly Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Asp Leu Met Gly Ser
        835                 840                 845             
Asn Gly Pro Gln Lys Phe Cys Ile Glu Lys Val Gly Lys Glu Asn Trp
    850                 855                 860                 
Leu Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr
865                 870                 875                 880 
Lys Ser Tyr Glu Gln Leu Lys Glu Lys Leu Leu Phe Ala Ile Glu Glu
                885                 890                 895     
Thr Glu Gly Phe Gly Gln Glu
            900             


<210> 7159
<211> 1709
<212> PRT
<213> Homo sapiens

<400> 7159
Met Asp Ala Asp Ser Ala Ser Ser Ser Glu Ser Glu Arg Asn Ile Thr
 1               5                  10                  15      
Ile Met Ala Ser Gly Asn Thr Gly Gly Glu Lys Asp Gly Leu Arg Asn
            20                  25                  30          
Ser Thr Gly Leu Gly Ser Gln Asn Lys Phe Val Val Gly Ser Ser Ser
        35                  40                  45              
Asn Asn Val Gly His Gly Ser Ser Thr Gly Pro Trp Gly Phe Ser His
    50                  55                  60                  
Gly Ala Ile Ile Ser Thr Cys Gln Val Ser Val Asp Ala Pro Glu Ser
65                  70                  75                  80  
Lys Ser Glu Ser Ser Asn Asn Arg Met Asn Ala Trp Gly Thr Val Ser
                85                  90                  95      
Ser Ser Ser Asn Gly Gly Leu Asn Pro Ser Thr Leu Asn Ser Ala Ser
            100                 105                 110         
Asn His Gly Ala Trp Pro Val Leu Glu Asn Asn Gly Leu Ala Leu Lys
        115                 120                 125             
Gly Pro Val Gly Ser Gly Ser Ser Gly Ile Asn Ile Gln Cys Ser Thr
    130                 135                 140                 
Ile Gly Gln Met Pro Asn Asn Gln Ser Ile Asn Ser Lys Val Ser Gly
145                 150                 155                 160 
Gly Ser Thr His Gly Thr Trp Gly Ser Leu Gln Glu Thr Cys Glu Ser
                165                 170                 175     
Glu Val Ser Gly Thr Gln Lys Val Ser Phe Ser Gly Gln Pro Gln Asn
            180                 185                 190         
Ile Thr Thr Glu Met Thr Gly Pro Asn Asn Thr Thr Asn Phe Met Thr
        195                 200                 205             
Ser Ser Leu Pro Asn Ser Gly Ser Val Gln Asn Asn Glu Leu Pro Ser
    210                 215                 220                 
Ser Asn Thr Gly Ala Trp Arg Val Ser Thr Met Asn His Pro Gln Met
225                 230                 235                 240 
Gln Ala Pro Ser Gly Met Asn Gly Thr Ser Leu Ser His Leu Ser Asn
                245                 250                 255     
Gly Glu Ser Lys Ser Gly Gly Ser Tyr Gly Thr Thr Trp Gly Ala Tyr
            260                 265                 270         
Gly Ser Asn Tyr Ser Gly Asp Lys Cys Ser Gly Pro Asn Gly Gln Ala
        275                 280                 285             
Asn Gly Asp Thr Val Asn Ala Thr Leu Met Gln Pro Gly Val Asn Gly
    290                 295                 300                 
Pro Met Gly Thr Asn Phe Gln Val Asn Thr Asn Lys Gly Gly Gly Val
305                 310                 315                 320 
Trp Glu Ser Gly Ala Ala Asn Ser Gln Ser Thr Ser Trp Gly Ser Gly
                325                 330                 335     
Asn Gly Ala Asn Ser Gly Gly Ser Arg Arg Gly Trp Gly Thr Pro Ala
            340                 345                 350         
Gln Asn Thr Gly Thr Asn Leu Pro Ser Val Glu Trp Asn Lys Leu Pro
        355                 360                 365             
Ser Asn Gln His Ser Asn Asp Ser Ala Asn Gly Asn Gly Lys Thr Phe
    370                 375                 380                 
Thr Asn Gly Trp Lys Ser Thr Glu Glu Glu Asp Gln Gly Ser Ala Thr
385                 390                 395                 400 
Ser Gln Thr Asn Glu Gln Ser Ser Val Trp Ala Lys Thr Gly Gly Thr
                405                 410                 415     
Val Glu Ser Asp Gly Ser Thr Glu Ser Thr Gly Arg Leu Glu Glu Lys
            420                 425                 430         
Gly Thr Gly Glu Ser Gln Ser Arg Asp Arg Arg Lys Ile Asp Gln His
        435                 440                 445             
Thr Leu Leu Gln Ser Ile Val Asn Arg Thr Asp Leu Asp Pro Arg Val
    450                 455                 460                 
Leu Ser Asn Ser Gly Trp Gly Gln Thr Pro Ile Lys Gln Asn Thr Ala
465                 470                 475                 480 
Trp Asp Thr Glu Thr Ser Pro Arg Gly Glu Arg Lys Thr Asp Asn Gly
                485                 490                 495     
Thr Glu Ala Trp Gly Ser Ser Ala Thr Gln Thr Phe Asn Ser Gly Ala
            500                 505                 510         
Cys Ile Asp Lys Thr Ser Pro Asn Gly Asn Asp Thr Ser Ser Val Ser
        515                 520                 525             
Gly Trp Gly Asp Pro Lys Pro Ala Leu Arg Trp Gly Asp Ser Lys Gly
    530                 535                 540                 
Ser Asn Cys Gln Gly Gly Trp Glu Asp Asp Ser Ala Ala Thr Gly Met
545                 550                 555                 560 
Val Lys Ser Asn Gln Trp Gly Asn Cys Lys Glu Glu Lys Ala Ala Trp
                565                 570                 575     
Asn Asp Ser Gln Lys Asn Lys Gln Gly Trp Gly Asp Gly Gln Lys Ser
            580                 585                 590         
Ser Gln Gly Trp Ser Val Ser Ala Ser Asp Asn Trp Gly Glu Thr Ser
        595                 600                 605             
Arg Asn Asn His Trp Gly Glu Ala Asn Lys Lys Ser Ser Ser Gly Gly
    610                 615                 620                 
Ser Asp Ser Asp Arg Ser Val Ser Gly Trp Asn Glu Leu Gly Lys Thr
625                 630                 635                 640 
Ser Ser Phe Thr Trp Gly Asn Asn Ile Asn Pro Asn Asn Ser Ser Gly
                645                 650                 655     
Trp Asp Glu Ser Ser Lys Pro Thr Pro Ser Gln Gly Trp Gly Asp Pro
            660                 665                 670         
Pro Lys Ser Asn Gln Ser Leu Gly Trp Gly Asp Ser Ser Lys Pro Val
        675                 680                 685             
Ser Ser Pro Asp Trp Asn Lys Gln Gln Asp Ile Val Gly Ser Trp Gly
    690                 695                 700                 
Ile Pro Pro Ala Thr Gly Lys Pro Pro Gly Thr Gly Trp Leu Gly Gly
705                 710                 715                 720 
Pro Ile Pro Ala Pro Ala Lys Glu Glu Glu Pro Thr Gly Trp Glu Glu
                725                 730                 735     
Pro Ser Pro Glu Ser Ile Arg Arg Lys Met Glu Ile Asp Asp Gly Thr
            740                 745                 750         
Ser Ala Trp Gly Asp Pro Ser Lys Tyr Asn Tyr Lys Asn Val Asn Met
        755                 760                 765             
Trp Asn Lys Asn Val Pro Asn Gly Asn Ser Arg Ser Asp Gln Gln Ala
    770                 775                 780                 
Gln Val His Gln Leu Leu Thr Pro Ala Ser Ala Ile Ser Asn Lys Glu
785                 790                 795                 800 
Ala Ser Ser Gly Ser Gly Trp Gly Glu Pro Trp Gly Glu Pro Ser Thr
                805                 810                 815     
Pro Ala Thr Thr Val Asp Asn Gly Thr Ser Ala Trp Gly Lys Pro Ile
            820                 825                 830         
Asp Ser Gly Pro Ser Trp Gly Glu Pro Ile Ala Ala Ala Ser Ser Thr
        835                 840                 845             
Ser Thr Trp Gly Ser Ser Ser Val Gly Pro Gln Ala Leu Ser Lys Ser
    850                 855                 860                 
Gly Pro Lys Ser Met Gln Asp Gly Trp Cys Gly Asp Asp Met Pro Leu
865                 870                 875                 880 
Pro Gly Asn Arg Pro Thr Gly Trp Glu Glu Glu Glu Asp Val Glu Ile
                885                 890                 895     
Gly Met Trp Asn Ser Asn Ser Ser Gln Glu Leu Asn Ser Ser Leu Asn
            900                 905                 910         
Trp Pro Pro Tyr Thr Lys Lys Met Ser Ser Lys Gly Leu Ser Gly Lys
        915                 920                 925             
Lys Arg Arg Arg Glu Arg Gly Met Met Lys Gly Gly Asn Lys Gln Glu
    930                 935                 940                 
Glu Ala Trp Ile Asn Pro Phe Val Lys Gln Phe Ser Asn Ile Ser Phe
945                 950                 955                 960 
Ser Arg Asp Ser Pro Glu Glu Asn Val Gln Ser Asn Lys Met Asp Leu
                965                 970                 975     
Ser Gly Gly Met Leu Gln Asp Lys Arg Met Glu Ile Asp Lys His Ser
            980                 985                 990         
Leu Asn Ile Gly Asp Tyr Asn Arg Thr Val Gly Lys Gly Pro Gly Ser
        995                 1000                1005            
Arg Pro Gln Ile Ser Lys Glu Ser Ser Met Glu Arg Asn Pro Tyr Phe
    1010                1015                1020                
Asp Lys Asp Gly Ile Val Ala Asp Glu Ser Gln Asn Met Gln Phe Met
1025                1030                1035                1040
Ser Ser Gln Ser Met Lys Leu Pro Pro Ser Asn Ser Ala Leu Pro Asn
                1045                1050                1055    
Gln Ala Leu Gly Ser Ile Ala Gly Leu Gly Met Gln Asn Leu Asn Ser
            1060                1065                1070        
Val Arg Gln Asn Gly Asn Pro Ser Met Phe Gly Val Gly Asn Thr Ala
        1075                1080                1085            
Ala Gln Pro Arg Gly Met Gln Gln Pro Pro Ala Gln Pro Leu Ser Ser
    1090                1095                1100                
Ser Gln Pro Asn Leu Arg Ala Gln Val Pro Pro Pro Leu Leu Ser Pro
1105                1110                1115                1120
Gln Val Pro Val Ser Leu Leu Lys Tyr Ala Pro Asn Asn Gly Gly Leu
                1125                1130                1135    
Asn Pro Leu Phe Gly Pro Gln Gln Val Ala Met Leu Asn Gln Leu Ser
            1140                1145                1150        
Gln Leu Asn Gln Leu Ser Gln Ile Ser Gln Leu Gln Arg Leu Leu Ala
        1155                1160                1165            
Gln Gln Gln Arg Ala Gln Ser Gln Arg Ser Val Pro Ser Gly Asn Arg
    1170                1175                1180                
Pro Gln Gln Asp Gln Gln Gly Arg Pro Leu Ser Val Gln Gln Gln Met
1185                1190                1195                1200
Met Gln Gln Ser Arg Gln Leu Asp Pro Asn Leu Leu Val Lys Gln Gln
                1205                1210                1215    
Thr Pro Pro Ser Gln Gln Gln Pro Leu His Gln Pro Ala Met Lys Ser
            1220                1225                1230        
Phe Leu Asp Asn Val Met Pro His Thr Thr Pro Glu Leu Gln Lys Gly
        1235                1240                1245            
Pro Ser Pro Ile Asn Ala Phe Ser Asn Phe Pro Ile Gly Leu Asn Ser
    1250                1255                1260                
Asn Leu Asn Val Asn Met Asp Met Asn Ser Ile Lys Glu Pro Gln Ser
1265                1270                1275                1280
Arg Leu Arg Lys Trp Thr Thr Val Asp Ser Ile Ser Val Asn Thr Ser
                1285                1290                1295    
Leu Asp Gln Asn Ser Ser Lys His Gly Ala Ile Ser Ser Gly Phe Arg
            1300                1305                1310        
Leu Glu Glu Ser Pro Phe Val Pro Tyr Asp Phe Met Asn Ser Ser Thr
        1315                1320                1325            
Ser Pro Ala Ser Pro Pro Gly Ser Ile Gly Asp Gly Trp Pro Arg Ala
    1330                1335                1340                
Lys Ser Pro Asn Gly Ser Ser Ser Val Asn Trp Pro Pro Glu Phe Arg
1345                1350                1355                1360
Pro Gly Glu Pro Trp Lys Gly Tyr Pro Asn Ile Asp Pro Glu Thr Asp
                1365                1370                1375    
Pro Tyr Val Thr Pro Gly Ser Val Ile Asn Asn Leu Ser Ile Asn Thr
            1380                1385                1390        
Val Arg Glu Val Asp His Leu Arg Asp Arg Asn Ser Gly Ser Ser Ser
        1395                1400                1405            
Ser Leu Asn Thr Thr Leu Pro Ser Thr Ser Ala Trp Ser Ser Ile Arg
    1410                1415                1420                
Ala Ser Asn Tyr Asn Val Pro Leu Ser Ser Thr Ala Gln Ser Thr Ser
1425                1430                1435                1440
Ala Arg Asn Ser Asp Ser Lys Leu Thr Trp Ser Pro Gly Ser Val Thr
                1445                1450                1455    
Asn Thr Ser Leu Ala His Glu Leu Trp Lys Val Pro Leu Pro Pro Lys
            1460                1465                1470        
Asn Ile Thr Ala Pro Ser Arg Pro Pro Pro Gly Leu Thr Gly Gln Lys
        1475                1480                1485            
Pro Pro Leu Ser Thr Trp Asp Asn Ser Pro Leu Arg Ile Gly Gly Gly
    1490                1495                1500                
Trp Gly Asn Ser Asp Ala Arg Tyr Thr Pro Gly Ser Ser Trp Gly Glu
1505                1510                1515                1520
Ser Ser Ser Gly Arg Ile Thr Asn Trp Leu Val Leu Lys Asn Leu Thr
                1525                1530                1535    
Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys Met Gln His Gly
            1540                1545                1550        
Pro Leu Ile Thr Phe His Leu Asn Leu Pro His Gly Asn Ala Leu Val
        1555                1560                1565            
Arg Tyr Ser Ser Lys Glu Glu Val Val Lys Ala Gln Lys Ser Leu His
    1570                1575                1580                
Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala Ser Glu
1585                1590                1595                1600
Glu Glu Ile Ser Arg Phe Phe Ala Gln Ser Gln Ser Leu Thr Pro Ser
                1605                1610                1615    
Pro Gly Trp Gln Ser Leu Gly Ser Ser Gln Ser Arg Leu Gly Ser Leu
            1620                1625                1630        
Asp Cys Ser His Ser Phe Ser Ser Arg Thr Asp Leu Asn His Trp Asn
        1635                1640                1645            
Gly Ala Gly Leu Ser Gly Thr Asn Cys Gly Asp Leu His Gly Thr Ser
    1650                1655                1660                
Leu Trp Gly Thr Pro His Tyr Ser Thr Ser Leu Trp Gly Pro Pro Ser
1665                1670                1675                1680
Ser Ser Asp Pro Arg Gly Ile Ser Ser Pro Ser Pro Ile Asn Ala Phe
                1685                1690                1695    
Leu Ser Val Asp His Leu Gly Gly Gly Gly Glu Ser Met
            1700                1705                


<210> 7160
<211> 1963
<212> PRT
<213> Homo sapiens

<400> 7160
Cys Phe Arg Glu Leu Glu Ala Lys Ala Thr Lys Asp Val Glu Arg Asn
 1               5                  10                  15      
Leu Ser Arg Asp Leu Val Gln Glu Glu Glu Gln Leu Met Glu Glu Lys
            20                  25                  30          
Lys Lys Lys Lys Asp Asp Lys Lys Lys Lys Glu Ala Ala Gln Lys Lys
        35                  40                  45              
Ala Thr Glu Gln Lys Ile Lys Val Pro Glu Gln Ile Lys Pro Ser Val
    50                  55                  60                  
Ser Gln Pro Gln Pro Ala Asn Ser Asn Asn Gly Thr Ser Thr Ala Thr
65                  70                  75                  80  
Ser Thr Asn Asn Asn Ala Lys Arg Ala Thr Ala Asn Asn Gln Gln Pro
                85                  90                  95      
Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln Gln Gln Gln Pro Gln Gln
            100                 105                 110         
Gln Pro Gln Pro Gln Pro Gln Gln Gln Gln Pro Gln Gln Gln Pro Gln
        115                 120                 125             
Ala Leu Pro Arg Tyr Pro Arg Glu Val Pro Pro Arg Phe Arg His Gln
    130                 135                 140                 
Glu His Lys Gln Leu Leu Lys Arg Gly Gln His Phe Pro Val Ile Ala
145                 150                 155                 160 
Ala Asn Leu Gly Ser Ala Val Lys Val Leu Asn Ser Gln Ser Glu Ser
                165                 170                 175     
Ser Ala Leu Thr Asn Gln Gln Pro Gln Asn Asn Gly Glu Val Gln Asn
            180                 185                 190         
Ser Lys Asn Gln Ser Asp Ile Asn His Ser Thr Ser Gly Ser His Tyr
        195                 200                 205             
Glu Asn Ser Gln Arg Gly Pro Val Ser Ser Thr Ser Asp Ser Ser Thr
    210                 215                 220                 
Asn Cys Lys Asn Ala Val Val Ser Asp Leu Ser Glu Lys Glu Ala Trp
225                 230                 235                 240 
Pro Ser Ala Pro Gly Ser Asp Pro Glu Leu Ala Ser Glu Cys Met Asp
                245                 250                 255     
Ala Asp Ser Ala Ser Ser Ser Glu Ser Glu Arg Asn Ile Thr Ile Met
            260                 265                 270         
Ala Ser Gly Asn Thr Gly Gly Glu Lys Asp Gly Leu Arg Asn Ser Thr
        275                 280                 285             
Gly Leu Gly Ser Gln Asn Lys Phe Val Val Gly Ser Ser Ser Asn Asn
    290                 295                 300                 
Val Gly His Gly Ser Ser Thr Gly Pro Trp Gly Phe Ser His Gly Ala
305                 310                 315                 320 
Ile Ile Ser Thr Cys Gln Val Ser Val Asp Ala Pro Glu Ser Lys Ser
                325                 330                 335     
Glu Ser Ser Asn Asn Arg Met Asn Ala Trp Gly Thr Val Ser Ser Ser
            340                 345                 350         
Ser Asn Gly Gly Leu Asn Pro Ser Thr Leu Asn Ser Ala Ser Asn His
        355                 360                 365             
Gly Ala Trp Pro Val Leu Glu Asn Asn Gly Leu Ala Leu Lys Gly Pro
    370                 375                 380                 
Val Gly Ser Gly Ser Ser Gly Ile Asn Ile Gln Cys Ser Thr Ile Gly
385                 390                 395                 400 
Gln Met Pro Asn Asn Gln Ser Ile Asn Ser Lys Val Ser Gly Gly Ser
                405                 410                 415     
Thr His Gly Thr Trp Gly Ser Leu Gln Glu Thr Cys Glu Ser Glu Val
            420                 425                 430         
Ser Gly Thr Gln Lys Val Ser Phe Ser Gly Gln Pro Gln Asn Ile Thr
        435                 440                 445             
Thr Glu Met Thr Gly Pro Asn Asn Thr Thr Asn Phe Met Thr Ser Ser
    450                 455                 460                 
Leu Pro Asn Ser Gly Ser Val Gln Asn Asn Glu Leu Pro Ser Ser Asn
465                 470                 475                 480 
Thr Gly Ala Trp Arg Val Ser Thr Met Asn His Pro Gln Met Gln Ala
                485                 490                 495     
Pro Ser Gly Met Asn Gly Thr Ser Leu Ser His Leu Ser Asn Gly Glu
            500                 505                 510         
Ser Lys Ser Gly Gly Ser Tyr Gly Thr Thr Trp Gly Ala Tyr Gly Ser
        515                 520                 525             
Asn Tyr Ser Gly Asp Lys Cys Ser Gly Pro Asn Gly Gln Ala Asn Gly
    530                 535                 540                 
Asp Thr Val Asn Ala Thr Leu Met Gln Pro Gly Val Asn Gly Pro Met
545                 550                 555                 560 
Gly Thr Asn Phe Gln Val Asn Thr Asn Lys Gly Gly Gly Val Trp Glu
                565                 570                 575     
Ser Gly Ala Ala Asn Ser Gln Ser Thr Ser Trp Gly Ser Gly Asn Gly
            580                 585                 590         
Ala Asn Ser Gly Gly Ser Arg Arg Gly Trp Gly Thr Pro Ala Gln Asn
        595                 600                 605             
Thr Gly Thr Asn Leu Pro Ser Val Glu Trp Asn Lys Leu Pro Ser Asn
    610                 615                 620                 
Gln His Ser Asn Asp Ser Ala Asn Gly Asn Gly Lys Thr Phe Thr Asn
625                 630                 635                 640 
Gly Trp Lys Ser Thr Glu Glu Glu Asp Gln Gly Ser Ala Thr Ser Gln
                645                 650                 655     
Thr Asn Glu Gln Ser Ser Val Trp Ala Lys Thr Gly Gly Thr Val Glu
            660                 665                 670         
Ser Asp Gly Ser Thr Glu Ser Thr Gly Arg Leu Glu Glu Lys Gly Thr
        675                 680                 685             
Gly Glu Ser Gln Ser Arg Asp Arg Arg Lys Ile Asp Gln His Thr Leu
    690                 695                 700                 
Leu Gln Ser Ile Val Asn Arg Thr Asp Leu Asp Pro Arg Val Leu Ser
705                 710                 715                 720 
Asn Ser Gly Trp Gly Gln Thr Pro Ile Lys Gln Asn Thr Ala Trp Asp
                725                 730                 735     
Thr Glu Thr Ser Pro Arg Gly Glu Arg Lys Thr Asp Asn Gly Thr Glu
            740                 745                 750         
Ala Trp Gly Ser Ser Ala Thr Gln Thr Phe Asn Ser Gly Ala Cys Ile
        755                 760                 765             
Asp Lys Thr Ser Pro Asn Gly Asn Asp Thr Ser Ser Val Ser Gly Trp
    770                 775                 780                 
Gly Asp Pro Lys Pro Ala Leu Arg Trp Gly Asp Ser Lys Gly Ser Asn
785                 790                 795                 800 
Cys Gln Gly Gly Trp Glu Asp Asp Ser Ala Ala Thr Gly Met Val Lys
                805                 810                 815     
Ser Asn Gln Trp Gly Asn Cys Lys Glu Glu Lys Ala Ala Trp Asn Asp
            820                 825                 830         
Ser Gln Lys Asn Lys Gln Gly Trp Gly Asp Gly Gln Lys Ser Ser Gln
        835                 840                 845             
Gly Trp Ser Val Ser Ala Ser Asp Asn Trp Gly Glu Thr Ser Arg Asn
    850                 855                 860                 
Asn His Trp Gly Glu Ala Asn Lys Lys Ser Ser Ser Gly Gly Ser Asp
865                 870                 875                 880 
Ser Asp Arg Ser Val Ser Gly Trp Asn Glu Leu Gly Lys Thr Ser Ser
                885                 890                 895     
Phe Thr Trp Gly Asn Asn Ile Asn Pro Asn Asn Ser Ser Gly Trp Asp
            900                 905                 910         
Glu Ser Ser Lys Pro Thr Pro Ser Gln Gly Trp Gly Asp Pro Pro Lys
        915                 920                 925             
Ser Asn Gln Ser Leu Gly Trp Gly Asp Ser Ser Lys Pro Val Ser Ser
    930                 935                 940                 
Pro Asp Trp Asn Lys Gln Gln Asp Ile Val Gly Ser Trp Gly Ile Pro
945                 950                 955                 960 
Pro Ala Thr Gly Lys Pro Pro Gly Thr Gly Trp Leu Gly Gly Pro Ile
                965                 970                 975     
Pro Ala Pro Ala Lys Glu Glu Glu Pro Thr Gly Trp Glu Glu Pro Ser
            980                 985                 990         
Pro Glu Ser Ile Arg Arg Lys Met Glu Ile Asp Asp Gly Thr Ser Ala
        995                 1000                1005            
Trp Gly Asp Pro Ser Lys Tyr Asn Tyr Lys Asn Val Asn Met Trp Asn
    1010                1015                1020                
Lys Asn Val Pro Asn Gly Asn Ser Arg Ser Asp Gln Gln Ala Gln Val
1025                1030                1035                1040
His Gln Leu Leu Thr Pro Ala Ser Ala Ile Ser Asn Lys Glu Ala Ser
                1045                1050                1055    
Ser Gly Ser Gly Trp Gly Glu Pro Trp Gly Glu Pro Ser Thr Pro Ala
            1060                1065                1070        
Thr Thr Val Asp Asn Gly Thr Ser Ala Trp Gly Lys Pro Ile Asp Ser
        1075                1080                1085            
Gly Pro Ser Trp Gly Glu Pro Ile Ala Ala Ala Ser Ser Thr Ser Thr
    1090                1095                1100                
Trp Gly Ser Ser Ser Val Gly Pro Gln Ala Leu Ser Lys Ser Gly Pro
1105                1110                1115                1120
Lys Ser Met Gln Asp Gly Trp Cys Gly Asp Asp Met Pro Leu Pro Gly
                1125                1130                1135    
Asn Arg Pro Thr Gly Trp Glu Glu Glu Glu Asp Val Glu Ile Gly Met
            1140                1145                1150        
Trp Asn Ser Asn Ser Ser Gln Glu Leu Asn Ser Ser Leu Asn Trp Pro
        1155                1160                1165            
Pro Tyr Thr Lys Lys Met Ser Ser Lys Gly Leu Ser Gly Lys Lys Arg
    1170                1175                1180                
Arg Arg Glu Arg Gly Met Met Lys Gly Gly Asn Lys Gln Glu Glu Ala
1185                1190                1195                1200
Trp Ile Asn Pro Phe Val Lys Gln Phe Ser Asn Ile Ser Phe Ser Arg
                1205                1210                1215    
Asp Ser Pro Glu Glu Asn Val Gln Ser Asn Lys Met Asp Leu Ser Gly
            1220                1225                1230        
Gly Met Leu Gln Asp Lys Arg Met Glu Ile Asp Lys His Ser Leu Asn
        1235                1240                1245            
Ile Gly Asp Tyr Asn Arg Thr Val Gly Lys Gly Pro Gly Ser Arg Pro
    1250                1255                1260                
Gln Ile Ser Lys Glu Ser Ser Met Glu Arg Asn Pro Tyr Phe Asp Lys
1265                1270                1275                1280
Asp Gly Ile Val Ala Asp Glu Ser Gln Asn Met Gln Phe Met Ser Ser
                1285                1290                1295    
Gln Ser Met Lys Leu Pro Pro Ser Asn Ser Ala Leu Pro Asn Gln Ala
            1300                1305                1310        
Leu Gly Ser Ile Ala Gly Leu Gly Met Gln Asn Leu Asn Ser Val Arg
        1315                1320                1325            
Gln Asn Gly Asn Pro Ser Met Phe Gly Val Gly Asn Thr Ala Ala Gln
    1330                1335                1340                
Pro Arg Gly Met Gln Gln Pro Pro Ala Gln Pro Leu Ser Ser Ser Gln
1345                1350                1355                1360
Pro Asn Leu Arg Ala Gln Val Pro Pro Pro Leu Leu Ser Pro Gln Val
                1365                1370                1375    
Pro Val Ser Leu Leu Lys Tyr Ala Pro Asn Asn Gly Gly Leu Asn Pro
            1380                1385                1390        
Leu Phe Gly Pro Gln Gln Val Ala Met Leu Asn Gln Leu Ser Gln Leu
        1395                1400                1405            
Asn Gln Leu Ser Gln Ile Ser Gln Leu Gln Arg Leu Leu Ala Gln Gln
    1410                1415                1420                
Gln Arg Ala Gln Ser Gln Arg Ser Val Pro Ser Gly Asn Arg Pro Gln
1425                1430                1435                1440
Gln Asp Gln Gln Gly Arg Pro Leu Ser Val Gln Gln Gln Met Met Gln
                1445                1450                1455    
Gln Ser Arg Gln Leu Asp Pro Asn Leu Leu Val Lys Gln Gln Thr Pro
            1460                1465                1470        
Pro Ser Gln Gln Gln Pro Leu His Gln Pro Ala Met Lys Ser Phe Leu
        1475                1480                1485            
Asp Asn Val Met Pro His Thr Thr Pro Glu Leu Gln Lys Gly Pro Ser
    1490                1495                1500                
Pro Ile Asn Ala Phe Ser Asn Phe Pro Ile Gly Leu Asn Ser Asn Leu
1505                1510                1515                1520
Asn Val Asn Met Asp Met Asn Ser Ile Lys Glu Pro Gln Ser Arg Leu
                1525                1530                1535    
Arg Lys Trp Thr Thr Val Asp Ser Ile Ser Val Asn Thr Ser Leu Asp
            1540                1545                1550        
Gln Asn Ser Ser Lys His Gly Ala Ile Ser Ser Gly Phe Arg Leu Glu
        1555                1560                1565            
Glu Ser Pro Phe Val Pro Tyr Asp Phe Met Asn Ser Ser Thr Ser Pro
    1570                1575                1580                
Ala Ser Pro Pro Gly Ser Ile Gly Asp Gly Trp Pro Arg Ala Lys Ser
1585                1590                1595                1600
Pro Asn Gly Ser Ser Ser Val Asn Trp Pro Pro Glu Phe Arg Pro Gly
                1605                1610                1615    
Glu Pro Trp Lys Gly Tyr Pro Asn Ile Asp Pro Glu Thr Asp Pro Tyr
            1620                1625                1630        
Val Thr Pro Gly Ser Val Ile Asn Asn Leu Ser Ile Asn Thr Val Arg
        1635                1640                1645            
Glu Val Asp His Leu Arg Asp Arg Asn Ser Gly Ser Ser Ser Ser Leu
    1650                1655                1660                
Asn Thr Thr Leu Pro Ser Thr Ser Ala Trp Ser Ser Ile Arg Ala Ser
1665                1670                1675                1680
Asn Tyr Asn Val Pro Leu Ser Ser Thr Ala Gln Ser Thr Ser Ala Arg
                1685                1690                1695    
Asn Ser Asp Ser Lys Leu Thr Trp Ser Pro Gly Ser Val Thr Asn Thr
            1700                1705                1710        
Ser Leu Ala His Glu Leu Trp Lys Val Pro Leu Pro Pro Lys Asn Ile
        1715                1720                1725            
Thr Ala Pro Ser Arg Pro Pro Pro Gly Leu Thr Gly Gln Lys Pro Pro
    1730                1735                1740                
Leu Ser Thr Trp Asp Asn Ser Pro Leu Arg Ile Gly Gly Gly Trp Gly
1745                1750                1755                1760
Asn Ser Asp Ala Arg Tyr Thr Pro Gly Ser Ser Trp Gly Glu Ser Ser
                1765                1770                1775    
Ser Gly Arg Ile Thr Asn Trp Leu Val Leu Lys Asn Leu Thr Pro Gln
            1780                1785                1790        
Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys Met Gln His Gly Pro Leu
        1795                1800                1805            
Ile Thr Phe His Leu Asn Leu Pro His Gly Asn Ala Leu Val Arg Tyr
    1810                1815                1820                
Ser Ser Lys Glu Glu Val Val Lys Ala Gln Lys Ser Leu His Met Cys
1825                1830                1835                1840
Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala Ser Glu Glu Glu
                1845                1850                1855    
Ile Ser Arg Phe Phe Ala Gln Ser Gln Ser Leu Thr Pro Ser Pro Gly
            1860                1865                1870        
Trp Gln Ser Leu Gly Ser Ser Gln Ser Arg Leu Gly Ser Leu Asp Cys
        1875                1880                1885            
Ser His Ser Phe Ser Ser Arg Thr Asp Leu Asn His Trp Asn Gly Ala
    1890                1895                1900                
Gly Leu Ser Gly Thr Asn Cys Gly Asp Leu His Gly Thr Ser Leu Trp
1905                1910                1915                1920
Gly Thr Pro His Tyr Ser Thr Ser Leu Trp Gly Pro Pro Ser Ser Ser
                1925                1930                1935    
Asp Pro Arg Gly Ile Ser Ser Pro Ser Pro Ile Asn Ala Phe Leu Ser
            1940                1945                1950        
Val Asp His Leu Gly Gly Gly Gly Glu Ser Met
        1955                1960            


<210> 7161
<211> 451
<212> PRT
<213> Homo sapiens

<400> 7161
Met Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln
 1               5                  10                  15      
Ile Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser
            20                  25                  30          
Pro Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys
        35                  40                  45              
Asp Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala
    50                  55                  60                  
Val Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser
65                  70                  75                  80  
Pro Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His
                85                  90                  95      
Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu
            100                 105                 110         
Lys Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly
        115                 120                 125             
Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly
    130                 135                 140                 
Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg
145                 150                 155                 160 
Tyr Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Asn Gln Asp
                165                 170                 175     
Glu Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu
            180                 185                 190         
Lys Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr
        195                 200                 205             
Ala Leu Asn Arg Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser
    210                 215                 220                 
Phe Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr
225                 230                 235                 240 
Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu
                245                 250                 255     
Ile Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly
            260                 265                 270         
Tyr Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr
        275                 280                 285             
Thr Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met
    290                 295                 300                 
Val Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile
305                 310                 315                 320 
Leu Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser
                325                 330                 335     
Leu Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly
            340                 345                 350         
Pro Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro
        355                 360                 365             
Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile
    370                 375                 380                 
Ser Ser Leu Phe Glu Arg Thr Cys Arg Gln Tyr Asp Lys Leu Arg Lys
385                 390                 395                 400 
Arg Glu Ala Phe Leu Glu Gln Phe Arg Lys Glu Asp Met Phe Lys Asp
                405                 410                 415     
Asn Phe Asp Glu Met Asp Thr Ser Arg Glu Ile Val Gln Gln Leu Ile
            420                 425                 430         
Asp Glu Tyr His Ala Ala Thr Arg Pro Asp Tyr Ile Ser Trp Gly Thr
        435                 440                 445             
Gln Glu Gln
    450     


<210> 7162
<211> 219
<212> PRT
<213> Homo sapiens

<400> 7162
Met Asp Ser Gly Thr Arg Pro Val Gly Ser Cys Cys Ser Ser Pro Ala
 1               5                  10                  15      
Gly Leu Ser Arg Glu Tyr Lys Leu Val Met Leu Gly Ala Gly Gly Val
            20                  25                  30          
Gly Lys Ser Ala Met Thr Met Gln Phe Ile Ser His Arg Phe Pro Glu
        35                  40                  45              
Asp His Asp Pro Thr Ile Glu Asp Ala Tyr Lys Ile Arg Ile Arg Ile
    50                  55                  60                  
Asp Asp Glu Pro Ala Asn Leu Asp Ile Leu Asp Thr Ala Gly Gln Ala
65                  70                  75                  80  
Glu Phe Thr Ala Met Arg Asp Gln Tyr Met Arg Ala Gly Glu Gly Phe
                85                  90                  95      
Ile Ile Cys Tyr Ser Ile Thr Asp Arg Arg Ser Phe His Glu Val Arg
            100                 105                 110         
Glu Phe Lys Gln Leu Ile Tyr Arg Val Arg Arg Thr Asp Asp Thr Pro
        115                 120                 125             
Val Val Leu Val Gly Asn Lys Ser Asp Leu Lys Gln Leu Arg Gln Val
    130                 135                 140                 
Thr Lys Glu Glu Gly Leu Ala Leu Ala Arg Glu Phe Ser Cys Pro Phe
145                 150                 155                 160 
Phe Glu Thr Ser Ala Ala Tyr Arg Tyr Tyr Ile Asp Asp Val Phe His
                165                 170                 175     
Ala Leu Val Arg Glu Ile Arg Arg Lys Glu Lys Glu Ala Val Leu Ala
            180                 185                 190         
Met Glu Lys Lys Ser Lys Pro Lys Asn Ser Val Trp Lys Arg Leu Lys
        195                 200                 205             
Ser Pro Phe Arg Lys Lys Lys Asp Ser Val Thr
    210                 215                 


<210> 7163
<211> 521
<212> PRT
<213> Homo sapiens

<400> 7163
Met Ala Asp Asn Glu Lys Leu Asp Asn Gln Arg Leu Lys Asn Phe Lys
 1               5                  10                  15      
Asn Lys Gly Arg Asp Leu Glu Thr Met Arg Arg Gln Arg Asn Glu Val
            20                  25                  30          
Val Val Glu Leu Arg Lys Asn Lys Arg Asp Glu His Leu Leu Lys Arg
        35                  40                  45              
Arg Asn Val Pro His Glu Asp Ile Cys Glu Asp Ser Asp Ile Asp Gly
    50                  55                  60                  
Asp Tyr Arg Val Gln Asn Thr Ser Leu Glu Ala Ile Val Gln Asn Ala
65                  70                  75                  80  
Ser Ser Asp Asn Gln Gly Ile Gln Leu Ser Ala Val Gln Ala Ala Arg
                85                  90                  95      
Lys Leu Leu Ser Ser Asp Arg Asn Pro Pro Ile Asp Asp Leu Ile Lys
            100                 105                 110         
Ser Gly Ile Leu Pro Ile Leu Val His Cys Leu Glu Arg Asp Asp Asn
        115                 120                 125             
Pro Ser Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser
    130                 135                 140                 
Gly Thr Ser Glu Gln Thr Gln Ala Val Val Gln Ser Asn Ala Val Pro
145                 150                 155                 160 
Leu Phe Leu Arg Leu Leu His Ser Pro His Gln Asn Val Cys Glu Gln
                165                 170                 175     
Ala Val Trp Ala Leu Gly Asn Ile Ile Gly Asp Gly Pro Gln Cys Arg
            180                 185                 190         
Asp Tyr Val Ile Ser Leu Gly Val Val Lys Pro Leu Leu Ser Phe Ile
        195                 200                 205             
Ser Pro Ser Ile Pro Ile Thr Phe Leu Arg Asn Val Thr Trp Val Met
    210                 215                 220                 
Val Asn Leu Cys Arg His Lys Asp Pro Pro Pro Pro Met Glu Thr Ile
225                 230                 235                 240 
Gln Glu Ile Leu Pro Ala Leu Cys Val Leu Ile His His Thr Asp Val
                245                 250                 255     
Asn Ile Leu Val Asp Thr Val Trp Ala Leu Ser Tyr Leu Thr Asp Ala
            260                 265                 270         
Gly Asn Glu Gln Ile Gln Met Val Ile Asp Ser Gly Ile Val Pro His
        275                 280                 285             
Leu Val Pro Leu Leu Ser His Gln Glu Val Lys Val Gln Thr Ala Ala
    290                 295                 300                 
Leu Arg Ala Val Gly Asn Ile Val Thr Gly Thr Asp Glu Gln Thr Gln
305                 310                 315                 320 
Val Val Leu Asn Cys Asp Ala Leu Ser His Phe Pro Ala Leu Leu Thr
                325                 330                 335     
His Pro Lys Glu Lys Ile Asn Lys Glu Ala Val Trp Phe Leu Ser Asn
            340                 345                 350         
Ile Thr Ala Gly Asn Gln Gln Gln Val Gln Ala Val Ile Asp Ala Asn
        355                 360                 365             
Leu Val Pro Met Ile Ile His Leu Leu Asp Lys Gly Asp Phe Gly Thr
    370                 375                 380                 
Gln Lys Glu Ala Ala Trp Ala Ile Ser Asn Leu Thr Ile Ser Gly Arg
385                 390                 395                 400 
Lys Asp Gln Val Ala Tyr Leu Ile Gln Gln Asn Val Ile Pro Pro Phe
                405                 410                 415     
Cys Asn Leu Leu Thr Val Lys Asp Ala Gln Val Val Gln Val Val Leu
            420                 425                 430         
Asp Gly Leu Ser Asn Ile Leu Lys Met Ala Glu Asp Glu Ala Glu Thr
        435                 440                 445             
Ile Gly Asn Leu Ile Glu Glu Cys Gly Gly Leu Glu Lys Ile Glu Gln
    450                 455                 460                 
Leu Gln Asn His Glu Asn Glu Asp Ile Tyr Lys Leu Ala Tyr Glu Ile
465                 470                 475                 480 
Ile Asp Gln Phe Phe Ser Ser Asp Asp Ile Asp Glu Asp Pro Ser Leu
                485                 490                 495     
Val Pro Glu Ala Ile Gln Gly Gly Thr Phe Gly Phe Asn Ser Ser Ala
            500                 505                 510         
Asn Val Pro Thr Glu Gly Phe Gln Phe
        515                 520     


<210> 7164
<211> 529
<212> PRT
<213> Homo sapiens

<400> 7164
Met Ser Ser Thr Val Ser Tyr Trp Ile Leu Asn Ser Thr Arg Asn Ser
 1               5                  10                  15      
Ile Ala Thr Leu Gln Gly Gly Arg Arg Leu Tyr Ser Arg Tyr Val Ser
            20                  25                  30          
Asn Arg Asn Lys Leu Lys Trp Arg Leu Phe Ser Arg Val Pro Pro Thr
        35                  40                  45              
Leu Asn Ser Ser Pro Cys Gly Gly Phe Thr Leu Cys Lys Ala Tyr Arg
    50                  55                  60                  
His Thr Ser Thr Glu Glu Asp Asp Phe His Leu Gln Leu Ser Pro Glu
65                  70                  75                  80  
Gln Ile Asn Glu Val Leu Arg Ala Gly Glu Thr Thr His Lys Ile Leu
                85                  90                  95      
Asp Leu Glu Ser Arg Val Pro Asn Ser Val Leu Arg Phe Glu Ser Asn
            100                 105                 110         
Gln Leu Ala Ala Asn Ser Pro Val Glu Asp Arg Arg Gly Val Ala Ser
        115                 120                 125             
Cys Leu Gln Thr Asn Gly Leu Met Phe Gly Ile Phe Asp Gly His Gly
    130                 135                 140                 
Gly His Ala Cys Ala Gln Ala Val Ser Glu Arg Leu Phe Tyr Tyr Val
145                 150                 155                 160 
Ala Val Ser Leu Met Ser His Gln Thr Leu Glu His Met Glu Gly Ala
                165                 170                 175     
Met Glu Ser Met Lys Pro Leu Leu Pro Ile Leu His Trp Leu Lys His
            180                 185                 190         
Pro Gly Asp Ser Ile Tyr Lys Asp Val Thr Ser Val His Leu Asp His
        195                 200                 205             
Leu Arg Val Tyr Trp Gln Glu Leu Leu Asp Leu His Met Glu Met Gly
    210                 215                 220                 
Leu Ser Ile Glu Glu Ala Leu Met Tyr Ser Phe Gln Arg Leu Asp Ser
225                 230                 235                 240 
Asp Ile Ser Leu Glu Ile Gln Ala Pro Leu Glu Asp Glu Val Thr Arg
                245                 250                 255     
Asn Leu Ser Leu Gln Val Ala Phe Ser Gly Ala Thr Ala Cys Met Ala
            260                 265                 270         
His Val Asp Gly Ile His Leu His Val Ala Asn Ala Gly Asp Cys Arg
        275                 280                 285             
Ala Ile Leu Gly Val Gln Glu Asp Asn Gly Met Trp Ser Cys Leu Pro
    290                 295                 300                 
Leu Thr Arg Asp His Asn Ala Trp Asn Gln Ala Glu Leu Ser Arg Leu
305                 310                 315                 320 
Lys Arg Glu His Pro Glu Ser Glu Asp Arg Thr Ile Ile Met Glu Asp
                325                 330                 335     
Arg Leu Leu Gly Val Leu Ile Pro Cys Arg Ala Phe Gly Asp Val Gln
            340                 345                 350         
Leu Lys Trp Ser Lys Glu Leu Gln Arg Ser Ile Leu Glu Arg Gly Phe
        355                 360                 365             
Asn Thr Glu Ala Leu Asn Ile Tyr Gln Phe Thr Pro Pro His Tyr Tyr
    370                 375                 380                 
Thr Pro Pro Tyr Leu Thr Ala Glu Pro Glu Val Thr Tyr His Arg Leu
385                 390                 395                 400 
Arg Pro Gln Asp Lys Phe Leu Val Leu Ala Ser Asp Gly Leu Trp Asp
                405                 410                 415     
Met Leu Ser Asn Glu Asp Val Val Arg Leu Val Val Gly His Leu Ala
            420                 425                 430         
Glu Ala Asp Trp His Lys Thr Asp Leu Ala Gln Arg Pro Ala Asn Leu
        435                 440                 445             
Gly Leu Met Gln Ser Leu Leu Leu Gln Arg Lys Ala Ser Gly Leu His
    450                 455                 460                 
Glu Ala Asp Gln Asn Ala Ala Thr Arg Leu Ile Arg His Ala Ile Gly
465                 470                 475                 480 
Asn Asn Glu Tyr Gly Glu Met Glu Ala Glu Arg Leu Ala Ala Met Leu
                485                 490                 495     
Thr Leu Pro Glu Asp Leu Ala Arg Met Tyr Arg Asp Asp Ile Thr Val
            500                 505                 510         
Thr Val Val Tyr Phe Asn Ser Glu Ser Ile Gly Ala Tyr Tyr Lys Gly
        515                 520                 525             
Gly
    


<210> 7165
<211> 523
<212> PRT
<213> Homo sapiens

<400> 7165
Met Ala Ala Val Gly Arg Val Gly Ser Phe Gly Ser Ser Pro Pro Gly
 1               5                  10                  15      
Leu Ser Ser Thr Tyr Thr Gly Gly Pro Leu Gly Asn Glu Ile Ala Ser
            20                  25                  30          
Gly Asn Gly Gly Ala Ala Ala Gly Asp Asp Glu Asp Gly Gln Asn Leu
        35                  40                  45              
Trp Ser Cys Ile Leu Ser Glu Val Ser Thr Arg Ser Arg Ser Lys Leu
    50                  55                  60                  
Pro Ala Gly Lys Asn Val Leu Leu Leu Gly Glu Asp Gly Ala Gly Lys
65                  70                  75                  80  
Thr Ser Leu Ile Arg Lys Ile Gln Gly Ile Glu Glu Tyr Lys Lys Gly
                85                  90                  95      
Arg Gly Leu Glu Tyr Leu Tyr Leu Asn Val His Asp Glu Asp Arg Asp
            100                 105                 110         
Asp Gln Thr Arg Cys Asn Val Trp Ile Leu Asp Gly Asp Leu Tyr His
        115                 120                 125             
Lys Gly Leu Leu Lys Phe Ser Leu Asp Ala Val Ser Leu Lys Asp Thr
    130                 135                 140                 
Leu Val Met Leu Val Val Asp Met Ser Lys Pro Trp Thr Ala Leu Asp
145                 150                 155                 160 
Ser Leu Gln Lys Trp Ala Ser Val Val Arg Glu His Val Asp Lys Leu
                165                 170                 175     
Lys Ile Pro Pro Glu Glu Met Lys Gln Met Glu Gln Lys Leu Ile Arg
            180                 185                 190         
Asp Phe Gln Glu Tyr Val Glu Pro Gly Glu Asp Phe Pro Ala Ser Pro
        195                 200                 205             
Gln Arg Arg Asn Thr Ala Ser Gln Glu Asp Lys Asp Asp Ser Val Val
    210                 215                 220                 
Val Pro Leu Gly Ala Asp Thr Leu Thr His Asn Leu Gly Ile Pro Val
225                 230                 235                 240 
Leu Val Val Cys Thr Lys Cys Asp Ala Ile Ser Val Leu Glu Lys Glu
                245                 250                 255     
His Asp Tyr Arg Asp Glu His Phe Asp Phe Phe Gln Ser His Ile Arg
            260                 265                 270         
Lys Phe Cys Leu Arg Tyr Gly Ala Ala Leu Ile Tyr Thr Ser Val Lys
        275                 280                 285             
Glu Asn Lys Asn Ile Asp Leu Val Tyr Lys Tyr Ile Val Gln Lys Leu
    290                 295                 300                 
Tyr Gly Phe Pro Tyr Lys Ile Pro Ala Val Val Val Glu Lys Asp Ala
305                 310                 315                 320 
Val Phe Ile Pro Ala Gly Trp Asp Asn Asp Lys Lys Ile Gly Ile Leu
                325                 330                 335     
His Glu Asn Phe Gln Thr Leu Lys Ala Glu Asp Asn Phe Glu Asp Ile
            340                 345                 350         
Ile Thr Lys Pro Pro Val Arg Lys Phe Val His Glu Lys Glu Ile Met
        355                 360                 365             
Ala Glu Asp Asp Gln Val Phe Leu Met Lys Leu Gln Ser Leu Leu Ala
    370                 375                 380                 
Lys Gln Pro Pro Thr Ala Ala Gly Arg Pro Val Asp Ala Ser Pro Arg
385                 390                 395                 400 
Val Pro Gly Gly Ser Pro Arg Thr Pro Asn Arg Ser Val Ser Ser Asn
                405                 410                 415     
Val Ala Ser Val Ser Pro Ile Pro Ala Gly Ser Lys Lys Ile Asp Pro
            420                 425                 430         
Asn Met Lys Ala Gly Ala Thr Ser Glu Gly Val Leu Ala Asn Phe Phe
        435                 440                 445             
Asn Ser Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly Gly Pro Gly Val
    450                 455                 460                 
Ser Gly Gly Ser Pro Ala Gly Gly Ala Gly Gly Gly Ser Ser Gly Leu
465                 470                 475                 480 
Pro Pro Ser Thr Lys Lys Ser Gly Gln Lys Pro Val Leu Asp Val His
                485                 490                 495     
Ala Glu Leu Asp Arg Ile Thr Arg Lys Pro Val Thr Val Ser Pro Thr
            500                 505                 510         
Thr Pro Thr Ser Pro Thr Glu Gly Glu Ala Ser
        515                 520             


<210> 7166
<211> 2712
<212> PRT
<213> Homo sapiens

<400> 7166
Met Ala Ala Ser Glu Arg Leu Tyr Glu Leu Trp Leu Leu Tyr Tyr Ala
 1               5                  10                  15      
Gln Lys Asp Leu Gly Tyr Leu Gln Gln Trp Leu Lys Ala Phe Val Gly
            20                  25                  30          
Ala Phe Lys Lys Ser Ile Ser Leu Ser Ser Leu Glu Pro Arg Arg Pro
        35                  40                  45              
Glu Glu Ala Gly Ala Glu Val Pro Leu Leu Pro Leu Asp Glu Leu His
    50                  55                  60                  
Val Leu Ala Glu Gln Leu His Gln Ala Asp Leu Glu Gln Ala Leu Leu
65                  70                  75                  80  
Leu Leu Lys Leu Phe Ile Ile Leu Cys Arg Asn Leu Glu Asn Ile Glu
                85                  90                  95      
Ala Gly Arg Gly Gln Val Leu Val Pro Arg Val Leu Ala Leu Leu Thr
            100                 105                 110         
Lys Leu Val Ala Glu Leu Lys Gly Cys Pro Pro Pro Gln Gly Arg Gly
        115                 120                 125             
Thr Gln Leu Glu Asn Val Ala Leu His Ala Leu Leu Leu Cys Glu Gly
    130                 135                 140                 
Leu Phe Asp Pro Tyr Gln Thr Trp Arg Arg Gln Arg Ser Gly Glu Val
145                 150                 155                 160 
Ile Ser Ser Lys Glu Lys Ser Lys Tyr Lys Phe Pro Pro Ala Ala Leu
                165                 170                 175     
Pro Gln Glu Phe Ser Ala Phe Phe Gln Gly Thr Thr Trp Trp Trp Leu
            180                 185                 190         
His Ala Gly Leu Gly Glu Pro Lys Thr Lys Gln Glu Phe Arg Asp Arg
        195                 200                 205             
Asp Lys Arg Arg His Leu Gly Leu Glu Arg Gly Pro Pro Ile Ser Leu
    210                 215                 220                 
His Ala Ser Pro Pro Ile Pro Glu Thr Gln Glu Val Ser Pro Pro Pro
225                 230                 235                 240 
Val Pro Trp Leu Leu Glu Asp Leu Val Pro Arg Thr Ala Val Ala Ala
                245                 250                 255     
Cys Ser Gln Pro Cys Asn Leu Gly Asp Ile Thr Leu Pro Thr Pro Pro
            260                 265                 270         
Tyr Pro Glu Ser Leu Gln Asn Ala Asp His Leu Pro Pro Ile Leu Leu
        275                 280                 285             
Leu Arg Leu Ile His Leu Phe Cys Ala Val Leu Ala Gly Gly Lys Glu
    290                 295                 300                 
Asn Gly Gln Met Ala Val Ser Asp Gly Ser Val Lys Gly Leu Leu Ser
305                 310                 315                 320 
Val Val Arg Gly Trp Ser Arg Gly Pro Ala Pro Asp Pro Cys Leu Val
                325                 330                 335     
Pro Leu Ala Leu Glu Ala Leu Val Gly Ala Val His Val Leu His Ala
            340                 345                 350         
Ser Arg Ala Pro Pro Arg Gly Pro Glu Leu Arg Ala Leu Leu Glu Ser
        355                 360                 365             
Tyr Phe His Val Leu Asn Ala Asp Trp Pro Ala Gly Leu Ser Ser Gly
    370                 375                 380                 
Pro Glu Glu Ala Leu Val Thr Leu Arg Val Ser Met Leu Asp Ala Ile
385                 390                 395                 400 
Pro Met Met Leu Ala Cys Glu Asp Arg Pro Val Leu Gln Ala Thr Phe
                405                 410                 415     
Leu Ser Asn Asn Cys Phe Glu His Leu Thr Arg Leu Ile Gln Asn Ser
            420                 425                 430         
Lys Leu Tyr Leu Gln Ser Arg Ala Pro Pro Glu Gly Asp Ser Asp Leu
        435                 440                 445             
Ala Thr Arg Leu Leu Thr Glu Pro Asp Val Gln Lys Val Leu Asp Gln
    450                 455                 460                 
Asp Thr Asp Ala Ile Ala Val His Val Val Arg Val Leu Thr Cys Ile
465                 470                 475                 480 
Met Ser Asp Ser Pro Ser Ala Lys Glu Val Phe Lys Glu Arg Ile Gly
                485                 490                 495     
Tyr Pro His Leu Gln Glu Val Leu Gln Ser His Gly Pro Pro Thr His
            500                 505                 510         
Arg Leu Leu Gln Glu Leu Leu Asn Met Ala Val Glu Gly Asp His Ser
        515                 520                 525             
Met Cys Pro Pro Pro Pro Ile Arg Asn Glu Gln Pro Val Leu Val Leu
    530                 535                 540                 
Ala Gln Trp Leu Pro Ser Leu Pro Thr Ala Glu Leu Arg Leu Phe Leu
545                 550                 555                 560 
Ala Gln Arg Leu Arg Trp Leu Cys Asp Ser Cys Pro Ala Ser Arg Ala
                565                 570                 575     
Thr Cys Val Gln Ala Gly Leu Val Gly Cys Leu Leu Glu Thr Leu Ser
            580                 585                 590         
Thr Gly Leu Ala Leu Glu Ala Arg Cys Gln Glu Gln Leu Leu Ala Leu
        595                 600                 605             
Leu Gln Ala Leu Gly Arg Val Ser Ile Arg Pro Met Glu Leu Arg His
    610                 615                 620                 
Leu Leu Arg Pro Arg Pro Gly Leu Asp Ser Glu Pro Gly Gly Ala Glu
625                 630                 635                 640 
Ala Gly Lys Ala Arg His Ala Gly Ala Val Ile Arg Thr Leu Ser Gly
                645                 650                 655     
Met Ala Arg His Gln Gly Pro Ala Arg Ala Leu Arg Tyr Phe Asp Leu
            660                 665                 670         
Thr Pro Ser Met Ala Gly Ile Met Val Pro Pro Val Gln Arg Trp Pro
        675                 680                 685             
Gly Pro Gly Phe Thr Phe His Ala Trp Leu Cys Leu His Pro Met Asp
    690                 695                 700                 
Thr Ala Pro Thr Pro Ala Pro Thr Arg Pro Leu Gln Arg Lys Gln Leu
705                 710                 715                 720 
Tyr Ser Phe Phe Thr Ser Ser Gly Ser Gly Phe Glu Ala Phe Phe Thr
                725                 730                 735     
Ala Ala Gly Thr Leu Val Val Ala Val Cys Thr Arg Lys Glu Tyr Leu
            740                 745                 750         
Thr Met Ser Leu Pro Glu Val Ser Phe Ala Asp Ser Ala Trp His Cys
        755                 760                 765             
Val Ala Ile Val His Val Pro Gly Arg Arg Pro Phe Ser Gln Asn Leu
    770                 775                 780                 
Val His Val Tyr Lys Asp Gly His Leu Val Lys Thr Ala Pro Leu Arg
785                 790                 795                 800 
Cys Pro Ser Leu Ser Glu Pro Phe Ser Ser Cys Cys Ile Gly Ser Ala
                805                 810                 815     
Gly Tyr Arg Thr Thr Thr Thr Thr Thr Gly Leu Pro Thr Pro Pro Val
            820                 825                 830         
Pro Ala Thr Leu Ala Tyr Thr His Pro Ala Leu Thr Arg Ser Gln Ser
        835                 840                 845             
Val Pro Ala Ser Thr Gly Leu Gly Trp Gly Ser Gly Leu Val Ala Pro
    850                 855                 860                 
Leu Gln Glu Gly Ser Ile Asp Ser Thr Leu Ala Gly Thr Gln Asp Thr
865                 870                 875                 880 
Arg Trp Gly Ser Pro Thr Ser Leu Glu Gly Glu Leu Gly Ala Val Ala
                885                 890                 895     
Ile Phe His Glu Ala Leu Gln Ala Thr Ala Leu Arg Thr Leu Cys Thr
            900                 905                 910         
Leu Gly Pro Asn Glu Thr Ala Pro Phe Lys Pro Glu Gly Glu Leu His
        915                 920                 925             
Glu Leu Ser Thr Arg Leu Leu Leu His Tyr Ser Pro Gln Ala Cys Lys
    930                 935                 940                 
Asn Asn Ile Cys Leu Asp Leu Ser Pro Ser His Gly Leu Asp Gly Arg
945                 950                 955                 960 
Leu Thr Gly His Arg Val Glu Thr Trp Asp Val Lys Asp Val Val Asn
                965                 970                 975     
Cys Val Gly Gly Met Gly Ala Leu Leu Pro Leu Leu Glu Arg Val Ala
            980                 985                 990         
Ala Gln Pro Lys Glu Ala Glu Ala Gly Pro Ala Glu Thr His Asp Leu
        995                 1000                1005            
Val Gly Pro Glu Leu Thr Ser Gly His Asn Thr Gln Gly Leu Val Leu
    1010                1015                1020                
Pro Leu Gly Lys Ser Ser Glu Glu Arg Met Glu Arg Asn Ala Val Ala
1025                1030                1035                1040
Ala Phe Leu Leu Met Leu Arg Asn Phe Leu Gln Gly His Met Val Asn
                1045                1050                1055    
Gln Glu Ser Leu Val Gln Cys Gln Gly Pro Ala Ile Ile Gly Ala Leu
            1060                1065                1070        
Leu Arg Lys Val Pro Ser Trp Ala Met Asp Met Asn Val Leu Met Ser
        1075                1080                1085            
Ala Gln Leu Leu Met Glu Gln Val Ala Ala Glu Gly Ser Gly Pro Leu
    1090                1095                1100                
Leu Tyr Leu Leu Tyr Gln His Leu Leu Phe Asn Phe His Leu Trp Thr
1105                1110                1115                1120
Leu Ser Asp Phe Ala Val Arg Leu Gly His Ile Gln Tyr Met Ser Ser
                1125                1130                1135    
Ile Val Arg Glu His Arg Gln Lys Leu Arg Lys Lys Tyr Gly Val Gln
            1140                1145                1150        
Phe Ile Leu Asp Ala Leu Arg Thr His Tyr Ser Pro Gln Arg Glu Arg
        1155                1160                1165            
Pro Leu Ala Ala Asp Asp Leu Arg Thr Val Gln Thr Ser Leu Leu Gly
    1170                1175                1180                
Leu Ala Arg Glu Phe Leu Val Arg Ser Leu Ser Ala Asp Asp Val Gln
1185                1190                1195                1200
Val Thr Gln Thr Met Leu Ser Phe Leu Ala Ala Thr Gly Asp Asp Gly
                1205                1210                1215    
Gln Ala Val Gly Ala Leu Asp Leu Leu Leu Ala Leu Leu His Gly Ser
            1220                1225                1230        
Leu Val Gln Glu Ser Leu Ala Val Phe Leu Leu Glu Pro Gly Asn Leu
        1235                1240                1245            
Glu Val Leu Leu Ala Leu Leu Val Arg Pro Gly Ser Leu Pro Leu Leu
    1250                1255                1260                
Pro Asp Arg Val Cys Lys Ile Leu Arg Arg Leu Gln Gln Asn Glu Arg
1265                1270                1275                1280
Leu Pro Glu Arg Ser Arg Gln Arg Leu Arg Leu Arg Glu Cys Gly Leu
                1285                1290                1295    
Gln Gly Leu Val Ala Cys Leu Pro Glu Gly Thr Val Ser Pro Gln Leu
            1300                1305                1310        
Cys Gln Gly Leu Tyr Lys Leu Phe Leu Gly Ala Gly Ser Gly Asn Thr
        1315                1320                1325            
Ala Gly Gly Gly Gly Ser Ser Gly Thr Leu Thr Pro Ala Ser Gln Pro
    1330                1335                1340                
Gly Thr Pro Ser Pro Leu Asp Gly Pro Arg Pro Phe Pro Ala Ala Pro
1345                1350                1355                1360
Gly Arg His Ser Ser Ser Leu Ser Asn Val Leu Glu Asp Gly Ser Leu
                1365                1370                1375    
Pro Glu Pro Thr Ile Ser Gly Asp Asp Thr Ser Asn Thr Ser Asn Pro
            1380                1385                1390        
Gln Gln Thr Ser Glu Glu Glu Leu Cys Asn Leu Leu Thr Asn Val Leu
        1395                1400                1405            
Phe Ser Val Thr Trp Arg Gly Val Glu Gly Ser Asp Glu Ala Ala Trp
    1410                1415                1420                
Arg Glu Arg Gly Gln Val Phe Ser Val Leu Thr Gln Leu Gly Ala Ser
1425                1430                1435                1440
Ala Thr Leu Val Arg Pro Pro Asp Cys Ile Lys Arg Ser Leu Leu Glu
                1445                1450                1455    
Met Met Leu Glu Ser Ala Leu Thr Asp Ile Lys Glu Ala Pro Val Gly
            1460                1465                1470        
Val Leu Ala Ser Leu Thr Gln Gln Ala Leu Trp Leu Leu Arg Leu Leu
        1475                1480                1485            
Gln Asp Phe Leu Cys Ala Glu Gly His Gly Asn Gln Glu Leu Trp Ser
    1490                1495                1500                
Glu Lys Leu Phe Glu Gly Val Cys Ser Leu Leu Asp Arg Leu Gly Ala
1505                1510                1515                1520
Trp Pro His Leu Ala Asn Gly Thr Ala Asp Leu Arg Glu Met Ala Gln
                1525                1530                1535    
Ile Gly Leu Arg Leu Val Leu Gly Tyr Ile Leu Leu Glu Asp Pro Gln
            1540                1545                1550        
Leu His Ala Gln Ala Tyr Val Arg Leu His Met Leu Leu Gln Thr Ala
        1555                1560                1565            
Val Pro Ala Arg Arg Glu Glu Ala Cys Tyr Val Leu Ser Lys Leu Glu
    1570                1575                1580                
Ala Ala Leu Gly Arg Val Leu Asn Thr Ser Ser Leu Glu Ser Ala Thr
1585                1590                1595                1600
Asp Glu Ala Gly Ser Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala
                1605                1610                1615    
Glu Arg Cys Ser Trp Leu Val Pro Leu Val Arg Thr Leu Leu Asp Arg
            1620                1625                1630        
Ala Tyr Glu Pro Leu Gly Leu Gln Trp Gly Leu Pro Ser Leu Pro Pro
        1635                1640                1645            
Thr Asn Gly Ser Pro Thr Phe Phe Glu Asp Phe Gln Ala Phe Cys Ala
    1650                1655                1660                
Thr Pro Glu Trp Arg His Phe Ile Asp Lys Gln Val Gln Pro Thr Met
1665                1670                1675                1680
Ser Gln Phe Glu Met Asp Thr Tyr Ala Lys Ser His Asp Leu Met Ser
                1685                1690                1695    
Gly Phe Trp Asn Ala Cys Tyr Asp Met Leu Met Ser Ser Gly Gln Arg
            1700                1705                1710        
Arg Gln Trp Glu Arg Ala Gln Ser Arg Arg Ala Phe Gln Glu Leu Val
        1715                1720                1725            
Leu Glu Pro Ala Gln Arg Arg Ala Arg Leu Glu Gly Leu Arg Tyr Thr
    1730                1735                1740                
Ala Val Leu Lys Gln Gln Ala Thr Gln His Ser Met Ala Leu Leu His
1745                1750                1755                1760
Trp Gly Ala Leu Trp Arg Gln Leu Ala Ser Pro Cys Gly Ala Trp Ala
                1765                1770                1775    
Leu Arg Asp Thr Pro Ile Pro Arg Trp Lys Leu Ser Ser Ala Glu Thr
            1780                1785                1790        
Tyr Ser Arg Met Arg Leu Lys Leu Val Pro Asn His His Phe Asp Pro
        1795                1800                1805            
His Leu Glu Ala Ser Ala Leu Arg Asp Asn Leu Gly Glu Val Pro Leu
    1810                1815                1820                
Thr Pro Thr Glu Glu Ala Ser Leu Pro Leu Ala Val Thr Lys Glu Ala
1825                1830                1835                1840
Lys Val Ser Thr Pro Pro Glu Leu Leu Gln Glu Asp Gln Leu Gly Glu
                1845                1850                1855    
Asp Glu Leu Ala Glu Leu Glu Thr Pro Met Glu Ala Ala Glu Leu Asp
            1860                1865                1870        
Glu Gln Arg Glu Lys Leu Val Leu Ser Ala Glu Cys Gln Leu Val Thr
        1875                1880                1885            
Val Val Ala Val Val Pro Gly Leu Leu Glu Val Thr Thr Gln Asn Val
    1890                1895                1900                
Tyr Phe Tyr Asp Gly Ser Thr Glu Arg Val Glu Thr Glu Glu Gly Ile
1905                1910                1915                1920
Gly Tyr Asp Phe Arg Arg Pro Leu Ala Gln Leu Arg Glu Val His Leu
                1925                1930                1935    
Arg Arg Phe Asn Leu Arg Arg Ser Ala Leu Glu Leu Phe Phe Ile Asp
            1940                1945                1950        
Gln Ala Asn Tyr Phe Leu Asn Phe Pro Cys Lys Val Gly Thr Thr Pro
        1955                1960                1965            
Val Ser Ser Pro Ser Gln Thr Pro Arg Pro Gln Pro Gly Pro Ile Pro
    1970                1975                1980                
Pro His Thr Gln Val Arg Asn Gln Val Tyr Ser Trp Leu Leu Arg Leu
1985                1990                1995                2000
Arg Pro Pro Ser Gln Gly Tyr Leu Ser Ser Arg Ser Pro Gln Glu Met
                2005                2010                2015    
Leu Arg Ala Ser Gly Leu Thr Gln Lys Trp Val Gln Arg Glu Ile Ser
            2020                2025                2030        
Asn Phe Glu Tyr Leu Met Gln Leu Asn Thr Ile Ala Gly Arg Thr Tyr
        2035                2040                2045            
Asn Asp Leu Ser Gln Tyr Pro Val Phe Pro Trp Val Leu Gln Asp Tyr
    2050                2055                2060                
Val Ser Pro Thr Leu Asp Leu Ser Asn Pro Ala Val Phe Arg Asp Leu
2065                2070                2075                2080
Ser Lys Pro Ile Gly Val Val Asn Pro Lys His Ala Gln Leu Val Arg
                2085                2090                2095    
Glu Lys Tyr Glu Ser Phe Glu Asp Pro Ala Gly Thr Ile Asp Lys Phe
            2100                2105                2110        
His Tyr Gly Thr His Tyr Ser Asn Ala Ala Gly Val Met His Tyr Leu
        2115                2120                2125            
Ile Arg Val Glu Pro Phe Thr Ser Leu His Val Gln Leu Gln Ser Gly
    2130                2135                2140                
Arg Phe Asp Cys Ser Asp Arg Gln Phe His Ser Val Ala Ala Ala Trp
2145                2150                2155                2160
Gln Ala Arg Leu Glu Ser Pro Ala Asp Val Lys Glu Leu Ile Pro Glu
                2165                2170                2175    
Phe Phe Tyr Phe Pro Asp Phe Leu Glu Asn Gln Asn Gly Phe Asp Leu
            2180                2185                2190        
Gly Cys Leu Gln Leu Thr Asn Glu Lys Val Gly Asp Val Val Leu Pro
        2195                2200                2205            
Pro Trp Ala Ser Ser Pro Glu Asp Phe Ile Gln Gln His Arg Gln Ala
    2210                2215                2220                
Leu Glu Ser Glu Tyr Val Ser Ala His Leu His Glu Trp Ile Asp Leu
2225                2230                2235                2240
Ile Phe Gly Tyr Lys Gln Arg Gly Pro Ala Ala Glu Glu Ala Leu Asn
                2245                2250                2255    
Val Phe Tyr Tyr Cys Thr Tyr Glu Gly Ala Val Asp Leu Asp His Val
            2260                2265                2270        
Thr Asp Glu Arg Glu Arg Lys Ala Leu Glu Gly Ile Ile Ser Asn Phe
        2275                2280                2285            
Gly Gln Thr Pro Cys Gln Leu Leu Lys Glu Pro His Pro Thr Arg Leu
    2290                2295                2300                
Ser Ala Glu Glu Ala Ala His Arg Leu Ala Arg Leu Asp Thr Asn Ser
2305                2310                2315                2320
Pro Ser Ile Phe Gln His Leu Asp Glu Leu Lys Ala Phe Phe Ala Glu
                2325                2330                2335    
Val Val Ser Asp Gly Val Pro Leu Val Leu Ala Leu Val Pro His Arg
            2340                2345                2350        
Gln Pro His Ser Phe Ile Thr Gln Gly Ser Pro Asp Leu Leu Val Thr
        2355                2360                2365            
Val Ser Ala Ser Gly Leu Leu Gly Thr His Ser Trp Leu Pro Tyr Asp
    2370                2375                2380                
Arg Asn Ile Ser Asn Tyr Phe Ser Phe Ser Lys Asp Pro Thr Met Gly
2385                2390                2395                2400
Ser His Lys Thr Gln Arg Leu Leu Ser Gly Pro Trp Val Pro Gly Ser
                2405                2410                2415    
Gly Val Ser Gly Gln Ala Leu Ala Val Ala Pro Asp Gly Lys Leu Leu
            2420                2425                2430        
Phe Ser Gly Gly His Trp Asp Gly Ser Leu Arg Val Thr Ala Leu Pro
        2435                2440                2445            
Arg Gly Lys Leu Leu Ser Gln Leu Ser Cys His Leu Asp Val Val Thr
    2450                2455                2460                
Cys Leu Ala Leu Asp Thr Cys Gly Ile Tyr Leu Ile Ser Gly Ser Arg
2465                2470                2475                2480
Asp Thr Thr Cys Met Val Trp Arg Leu Leu His Gln Gly Gly Leu Ser
                2485                2490                2495    
Val Gly Leu Ala Pro Lys Pro Val Gln Val Leu Tyr Gly His Gly Ala
            2500                2505                2510        
Ala Val Ser Cys Val Ala Ile Ser Thr Glu Leu Asp Met Ala Val Ser
        2515                2520                2525            
Gly Ser Glu Asp Gly Thr Val Ile Ile His Thr Val Arg Arg Gly Gln
    2530                2535                2540                
Phe Val Ala Ala Leu Arg Pro Leu Gly Ala Thr Phe Pro Gly Pro Ile
2545                2550                2555                2560
Phe His Leu Ala Leu Gly Ser Glu Gly Gln Ile Val Val Gln Ser Ser
                2565                2570                2575    
Ala Trp Glu Arg Pro Gly Ala Gln Val Thr Tyr Ser Leu His Leu Tyr
            2580                2585                2590        
Ser Val Asn Gly Lys Leu Arg Ala Ser Leu Pro Leu Ala Glu Gln Pro
        2595                2600                2605            
Thr Ala Leu Thr Val Thr Glu Asp Phe Val Leu Leu Gly Thr Ala Gln
    2610                2615                2620                
Cys Ala Leu His Ile Leu Gln Leu Asn Thr Leu Leu Pro Ala Ala Pro
2625                2630                2635                2640
Pro Leu Pro Met Lys Val Ala Ile Arg Ser Val Ala Val Thr Lys Glu
                2645                2650                2655    
Arg Ser His Val Leu Val Gly Leu Glu Asp Gly Lys Leu Ile Val Val
            2660                2665                2670        
Val Ala Gly Gln Pro Ser Glu Val Arg Ser Ser Gln Phe Ala Arg Lys
        2675                2680                2685            
Leu Trp Arg Ser Ser Arg Arg Ile Ser Gln Val Ser Ser Gly Glu Thr
    2690                2695                2700                
Glu Tyr Asn Pro Thr Glu Ala Arg
2705                2710        


<210> 7167
<211> 363
<212> PRT
<213> Homo sapiens

<400> 7167
Met Gln Ala Phe Leu Lys Gly Thr Ser Ile Ser Thr Lys Pro Pro Leu
 1               5                  10                  15      
Thr Lys Asp Arg Gly Val Ala Ala Ser Ala Gly Ser Ser Gly Glu Asn
            20                  25                  30          
Lys Lys Ala Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys
        35                  40                  45              
Val Asp Glu Val Ala Phe Gln Glu Glu Val Val Ala Val Leu Lys Lys
    50                  55                  60                  
Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro
65                  70                  75                  80  
Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe
                85                  90                  95      
Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp
            100                 105                 110         
Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln
        115                 120                 125             
Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe
    130                 135                 140                 
Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln
145                 150                 155                 160 
Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe
                165                 170                 175     
Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser
            180                 185                 190         
Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln
        195                 200                 205             
Gln Arg Leu Leu Asp Ile Ala Lys Lys Glu Asn Val Lys Ile Ser Asp
    210                 215                 220                 
Glu Gly Ile Ala Tyr Leu Val Lys Val Ser Glu Gly Asp Leu Arg Lys
225                 230                 235                 240 
Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu
                245                 250                 255     
Ile Thr Glu Lys Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Glu
            260                 265                 270         
Lys Ile Asp Gly Val Phe Ala Ala Cys Gln Ser Gly Ser Phe Asp Lys
        275                 280                 285             
Leu Glu Ala Val Val Lys Asp Leu Ile Asp Glu Gly His Ala Ala Thr
    290                 295                 300                 
Gln Leu Val Asn Gln Leu His Asp Val Val Val Glu Asn Asn Leu Ser
305                 310                 315                 320 
Asp Lys Gln Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp Lys
                325                 330                 335     
Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Ile Ser Leu Cys
            340                 345                 350         
Ala Thr Val Met Gln Gln Leu Ser Gln Asn Cys
        355                 360             


<210> 7168
<211> 919
<212> PRT
<213> Homo sapiens

<400> 7168
Met Gly Thr Thr Ala Pro Gly Pro Ile His Leu Leu Glu Leu Cys Asp
 1               5                  10                  15      
Gln Lys Leu Met Glu Phe Leu Cys Asn Met Asp Asn Lys Asp Leu Val
            20                  25                  30          
Trp Leu Glu Glu Ile Gln Glu Glu Ala Glu Arg Met Phe Thr Arg Glu
        35                  40                  45              
Phe Ser Lys Glu Pro Glu Leu Met Pro Lys Thr Pro Ser Gln Lys Asn
    50                  55                  60                  
Arg Arg Lys Lys Arg Arg Ile Ser Tyr Val Gln Asp Glu Asn Arg Asp
65                  70                  75                  80  
Pro Ile Arg Arg Arg Leu Ser Arg Arg Lys Ser Arg Ser Ser Gln Leu
                85                  90                  95      
Ser Ser Arg Arg Leu Arg Ser Lys Asp Ser Val Glu Lys Leu Ala Thr
            100                 105                 110         
Val Val Gly Glu Asn Gly Ser Val Leu Arg Arg Val Thr Arg Ala Ala
        115                 120                 125             
Ala Ala Ala Ala Ala Ala Thr Met Ala Leu Ala Ala Pro Ser Ser Pro
    130                 135                 140                 
Thr Pro Glu Ser Pro Thr Met Leu Thr Lys Lys Pro Glu Asp Asn His
145                 150                 155                 160 
Thr Gln Cys Gln Leu Val Pro Val Val Glu Ile Gly Ile Ser Glu Arg
                165                 170                 175     
Gln Asn Ala Glu Gln His Val Thr Gln Leu Met Ser Thr Glu Pro Leu
            180                 185                 190         
Pro Arg Thr Leu Ser Pro Thr Pro Ala Ser Ala Thr Ala Pro Thr Ser
        195                 200                 205             
Gln Gly Ile Pro Thr Ser Asp Glu Glu Ser Thr Pro Lys Lys Ser Lys
    210                 215                 220                 
Ala Arg Ile Leu Glu Ser Ile Thr Val Ser Ser Leu Met Ala Thr Pro
225                 230                 235                 240 
Gln Asp Pro Lys Gly Gln Gly Val Gly Thr Gly Arg Ser Ala Ser Lys
                245                 250                 255     
Leu Arg Ile Ala Gln Val Ser Pro Gly Pro Arg Asp Ser Pro Ala Phe
            260                 265                 270         
Pro Asp Ser Pro Trp Arg Glu Arg Val Leu Ala Pro Ile Leu Pro Asp
        275                 280                 285             
Asn Phe Ser Thr Pro Thr Gly Ser Arg Thr Asp Ser Gln Ser Val Arg
    290                 295                 300                 
His Ser Pro Ile Ala Pro Ser Ser Pro Ser Pro Gln Val Leu Ala Gln
305                 310                 315                 320 
Lys Tyr Ser Leu Val Ala Lys Gln Glu Ser Val Val Arg Arg Ala Ser
                325                 330                 335     
Arg Arg Leu Ala Lys Lys Thr Ala Glu Glu Pro Ala Ala Ser Gly Arg
            340                 345                 350         
Ile Ile Cys His Ser Tyr Leu Glu Arg Leu Leu Asn Val Glu Val Pro
        355                 360                 365             
Gln Lys Val Gly Ser Glu Gln Lys Glu Pro Pro Glu Glu Ala Glu Pro
    370                 375                 380                 
Val Ala Ala Ala Glu Pro Glu Val Pro Glu Asn Asn Gly Asn Asn Ser
385                 390                 395                 400 
Trp Pro His Asn Asp Thr Glu Ile Ala Asn Ser Thr Pro Asn Pro Lys
                405                 410                 415     
Pro Ala Ala Ser Ser Pro Glu Thr Pro Ser Ala Gly Gln Gln Glu Ala
            420                 425                 430         
Lys Thr Asp Gln Ala Asp Gly Pro Arg Glu Pro Pro Gln Ser Ala Arg
        435                 440                 445             
Arg Lys Arg Ser Tyr Lys Gln Ala Val Ser Glu Leu Asp Glu Glu Gln
    450                 455                 460                 
His Leu Glu Asp Glu Glu Leu Gln Pro Pro Arg Ser Lys Thr Pro Ser
465                 470                 475                 480 
Ser Pro Cys Pro Ala Ser Lys Val Val Arg Pro Leu Arg Thr Phe Leu
                485                 490                 495     
His Thr Val Gln Arg Asn Gln Met Leu Met Thr Pro Thr Ser Ala Pro
            500                 505                 510         
Arg Ser Val Met Lys Ser Phe Ile Lys Arg Asn Thr Pro Leu Arg Met
        515                 520                 525             
Asp Pro Lys Glu Lys Glu Arg Gln Arg Leu Glu Asn Leu Arg Arg Lys
    530                 535                 540                 
Glu Glu Ala Glu Gln Leu Arg Arg Gln Lys Val Glu Glu Asp Lys Arg
545                 550                 555                 560 
Arg Arg Leu Glu Glu Val Lys Leu Lys Arg Glu Glu Arg Leu Arg Lys
                565                 570                 575     
Val Leu Gln Ala Arg Glu Arg Val Glu Gln Met Lys Glu Glu Lys Lys
            580                 585                 590         
Lys Gln Ile Glu Gln Lys Phe Ala Gln Ile Asp Glu Lys Thr Glu Lys
        595                 600                 605             
Ala Lys Glu Glu Arg Leu Ala Glu Glu Lys Ala Lys Lys Lys Ala Ala
    610                 615                 620                 
Ala Lys Lys Met Glu Glu Val Glu Ala Arg Arg Lys Gln Glu Glu Asp
625                 630                 635                 640 
Ala Arg Arg Leu Arg Trp Leu Gln Gln Glu Glu Glu Glu Arg Arg His
                645                 650                 655     
Gln Glu Leu Leu Gln Lys Lys Lys Glu Glu Glu Gln Glu Arg Leu Arg
            660                 665                 670         
Lys Ala Ala Glu Ala Lys Arg Leu Ala Glu Gln Arg Glu Gln Glu Arg
        675                 680                 685             
Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg
    690                 695                 700                 
Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Gln Leu
705                 710                 715                 720 
Ala Glu Gln Glu Arg Arg Arg Glu Gln Glu Arg Leu Gln Ala Glu Arg
                725                 730                 735     
Glu Leu Gln Glu Arg Glu Lys Ala Leu Arg Leu Gln Lys Glu Gln Leu
            740                 745                 750         
Gln Arg Glu Leu Glu Glu Lys Lys Lys Lys Glu Glu Gln Gln Arg Leu
        755                 760                 765             
Ala Glu Arg Gln Leu Gln Glu Glu Gln Glu Lys Lys Ala Lys Glu Ala
    770                 775                 780                 
Ala Gly Ala Ser Lys Ala Leu Asn Val Thr Val Asp Val Gln Ser Pro
785                 790                 795                 800 
Ala Cys Thr Ser Ser Pro Ile Thr Pro Gln Gly His Lys Ala Pro Pro
                805                 810                 815     
Gln Ile Asn Pro His Asn Tyr Gly Met Asp Leu Asn Ser Asp Asp Ser
            820                 825                 830         
Thr Asp Asp Glu Ala His Pro Arg Lys Pro Ile Pro Thr Trp Ala Arg
        835                 840                 845             
Gly Thr Pro Leu Ser Gln Ala Ile Ile His Gln Tyr Tyr Gln Pro Pro
    850                 855                 860                 
Asn Leu Leu Glu Leu Phe Gly Thr Ile Leu Pro Leu Asp Leu Glu Asp
865                 870                 875                 880 
Ile Phe Lys Lys Ser Lys Pro Arg Tyr His Lys Arg Thr Ser Ser Ala
                885                 890                 895     
Val Trp Asn Ser Pro Pro Leu Gln Gly Ala Arg Val Pro Ser Ser Leu
            900                 905                 910         
Ala Tyr Ser Leu Lys Lys His
        915                 


<210> 7169
<211> 159
<212> PRT
<213> Homo sapiens

<400> 7169
Met Ser Leu Ile Thr Cys Lys Phe Lys Asn Leu Gly Asn Leu His Ala
 1               5                  10                  15      
Gly Gly Cys Gly Tyr Ile Pro Leu Ser Ser Thr Arg Glu Glu Arg Val
            20                  25                  30          
Lys Asn Gly Ser Arg Val Val Ser Thr Ala Leu Leu Ser Ser Tyr His
        35                  40                  45              
Lys Gly Ile Ala Phe Val Ile Phe Pro Ser His His His Thr Pro Thr
    50                  55                  60                  
Arg Pro Pro Ser Pro Lys Pro Ser Gly Ser Gly Gly Tyr Leu Leu Asn
65                  70                  75                  80  
Leu Arg Arg Arg Asp Pro Pro Gln Ala Phe Leu Ser Gly Cys Pro Pro
                85                  90                  95      
Leu Pro Pro Arg Gly Ser Val Leu Leu Gly Cys Thr Pro Pro Arg Thr
            100                 105                 110         
Gln Phe Phe Val Phe His Val Val Ser Tyr Pro Leu Val Leu Gln Lys
        115                 120                 125             
Leu Leu Gln Thr Arg Asp Gln Lys Ser Ile Gly Ser Asn Ser Ser Cys
    130                 135                 140                 
Asp Thr Ser Glu Met Ser Asp Cys Trp Gln Val Thr Leu Ser Ile
145                 150                 155                 


<210> 7170
<211> 543
<212> PRT
<213> Homo sapiens

<400> 7170
Met Ala Ser Pro Asp Arg Ser Lys Arg Lys Ile Leu Lys Ala Lys Lys
 1               5                  10                  15      
Thr Met Pro Leu Ser Cys Arg Lys Gln Val Glu Met Leu Asn Lys Ser
            20                  25                  30          
Arg Asn Val Glu Ala Leu Lys Thr Ala Ile Gly Ser Asn Val Pro Ser
        35                  40                  45              
Gly Asn Gln Ser Phe Ser Pro Ser Val Ile Thr Arg Thr Thr Glu Ile
    50                  55                  60                  
Thr Lys Cys Ser Pro Ser Glu Asn Gly Ala Ser Ser Leu Asp Ser Asn
65                  70                  75                  80  
Lys Asn Ser Ile Ser Glu Lys Ser Lys Val Phe Ser Gln Asn Cys Ile
                85                  90                  95      
Lys Pro Val Glu Glu Ile Val His Ser Glu Thr Lys Leu Glu Gln Val
            100                 105                 110         
Val Cys Ser Tyr Gln Lys Pro Ser Arg Thr Thr Glu Ser Pro Ser Arg
        115                 120                 125             
Val Phe Thr Glu Glu Ala Lys Asp Ser Leu Asn Thr Ser Glu Asn Asp
    130                 135                 140                 
Ser Glu His Gln Thr Asn Val Thr Arg Ser Leu Phe Glu His Glu Gly
145                 150                 155                 160 
Ala Cys Ser Leu Lys Ser Ser Cys Cys Pro Pro Ser Val Leu Ser Gly
                165                 170                 175     
Val Val Gln Met Pro Glu Ser Thr Val Thr Ser Thr Val Gly Asp Lys
            180                 185                 190         
Lys Thr Asp Gln Met Val Phe His Leu Glu Thr Asn Ser Asn Ser Glu
        195                 200                 205             
Ser His Asp Lys Arg Gln Ser Asp Asn Ile Leu Cys Ser Glu Asp Ser
    210                 215                 220                 
Gly Phe Val Pro Val Glu Lys Thr Pro Asn Leu Val Asn Ser Val Thr
225                 230                 235                 240 
Ser Asn Asn Cys Ala Asp Asp Ile Leu Lys Thr Asp Glu Cys Ser Arg
                245                 250                 255     
Thr Ser Ile Ser Asn Cys Glu Ser Ala Asp Ser Thr Trp Gln Ser Ser
            260                 265                 270         
Leu Asp Thr Asn Asn Asn Ser His Tyr Gln Lys Lys Arg Met Phe Ser
        275                 280                 285             
Glu Asn Glu Glu Asn Val Lys Arg Met Lys Thr Ser Glu Gln Ile Asn
    290                 295                 300                 
Glu Asn Ile Cys Val Ser Leu Glu Arg Gln Thr Ala Phe Leu Glu Gln
305                 310                 315                 320 
Val Arg His Leu Ile Gln Gln Glu Ile Tyr Ser Ile Asn Tyr Glu Leu
                325                 330                 335     
Phe Asp Lys Lys Leu Lys Glu Leu Asn Gln Arg Ile Gly Lys Thr Glu
            340                 345                 350         
Cys Arg Asn Lys His Glu Gly Ile Ala Asp Lys Leu Leu Ala Lys Ile
        355                 360                 365             
Ala Lys Leu Gln Arg Arg Ile Lys Thr Val Leu Leu Phe Gln Arg Asn
    370                 375                 380                 
Cys Leu Lys Pro Asn Met Leu Ser Ser Asn Gly Ala Ser Lys Val Ala
385                 390                 395                 400 
Asn Ser Glu Ala Met Ile Leu Asp Lys Asn Leu Glu Ser Val Asn Ser
                405                 410                 415     
Pro Ile Glu Lys Ser Ser Val Asn Tyr Glu Pro Ser Asn Pro Ser Glu
            420                 425                 430         
Lys Gly Ser Lys Lys Ile Asn Leu Ser Ser Asp Gln Asn Lys Ser Val
        435                 440                 445             
Ser Glu Ser Asn Asn Asp Asp Val Met Leu Ile Ser Val Glu Ser Pro
    450                 455                 460                 
Asn Leu Thr Thr Pro Ile Thr Ser Asn Pro Thr Asp Thr Arg Lys Ile
465                 470                 475                 480 
Thr Ser Gly Asn Ser Ser Asn Ser Pro Asn Ala Glu Val Met Lys Val
                485                 490                 495     
Gln Tyr Pro Pro Trp Ser His Ile Arg Lys Leu Leu Gln Thr Gln Arg
            500                 505                 510         
Lys Gln Pro His Trp His Lys Met Gln Ser Arg Phe Leu Ser Pro Leu
        515                 520                 525             
Ser Thr Cys His Leu Ser Gln Asn His Gln His His Tyr Leu Asn
    530                 535                 540             


<210> 7171
<211> 1514
<212> PRT
<213> Homo sapiens

<400> 7171
Tyr Arg Ile Ile Gly Gly Asn Ser Gln Phe Thr Ile Asn Pro Ser Thr
 1               5                  10                  15      
Gly Gln Ile Ile Thr Ser Ala Leu Leu Asp Arg Glu Thr Lys Asp Asn
            20                  25                  30          
Tyr Thr Leu Val Val Val Cys Ser Asp Ala Gly Ser Pro Glu Pro Leu
        35                  40                  45              
Ser Ser Ser Thr Ser Val Leu Val Thr Val Thr Asp Val Asn Asp Asn
    50                  55                  60                  
Pro Pro Arg Phe Gln His His Pro Tyr Val Thr His Ile Pro Ser Pro
65                  70                  75                  80  
Thr Leu Pro Gly Ser Phe Val Phe Ala Val Thr Val Thr Asp Ala Asp
                85                  90                  95      
Ile Gly Pro Asn Ser Glu Leu His Tyr Ser Leu Ser Gly Arg Asn Ser
            100                 105                 110         
Glu Lys Phe His Ile Asp Pro Leu Arg Gly Ala Ile Met Ala Ala Gly
        115                 120                 125             
Pro Leu Asn Gly Ala Ser Glu Val Thr Phe Ser Val His Val Lys Asp
    130                 135                 140                 
Gly Gly Ser Phe Pro Lys Thr Asp Ser Thr Thr Val Thr Val Arg Phe
145                 150                 155                 160 
Val Asn Lys Ala Asp Phe Pro Lys Val Arg Ala Lys Glu Gln Thr Phe
                165                 170                 175     
Met Phe Pro Glu Asn Gln Pro Val Ser Ser Leu Val Thr Thr Ile Thr
            180                 185                 190         
Gly Ser Ser Leu Arg Gly Glu Pro Met Ser Tyr Tyr Ile Ala Ser Gly
        195                 200                 205             
Asn Leu Gly Asn Thr Phe Gln Ile Asp Gln Leu Thr Gly Gln Val Ser
    210                 215                 220                 
Ile Ser Gln Pro Leu Asp Phe Glu Lys Ile Gln Lys Tyr Val Val Trp
225                 230                 235                 240 
Ile Glu Ala Arg Asp Gly Gly Phe Pro Pro Phe Ser Ser Tyr Glu Lys
                245                 250                 255     
Leu Asp Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro Ile Phe Lys
            260                 265                 270         
Glu Asp Pro Phe Ile Ser Glu Ile Leu Glu Asn Leu Ser Pro Arg Lys
        275                 280                 285             
Ile Leu Thr Val Ser Ala Met Asp Lys Asp Ser Gly Pro Asn Gly Gln
    290                 295                 300                 
Leu Asp Tyr Glu Ile Val Asn Gly Asn Met Glu Asn Ser Phe Ser Ile
305                 310                 315                 320 
Asn His Ala Thr Gly Glu Ile Arg Ser Val Arg Pro Leu Asp Arg Glu
                325                 330                 335     
Lys Val Ser His Tyr Val Leu Thr Ile Lys Ser Ser Asp Lys Gly Ser
            340                 345                 350         
Pro Ser Gln Ser Thr Ser Val Lys Val Met Ile Asn Ile Leu Asp Glu
        355                 360                 365             
Asn Asp Asn Ala Pro Arg Phe Ser Gln Ile Phe Ser Ala His Val Pro
    370                 375                 380                 
Glu Asn Ser Pro Leu Gly Tyr Thr Val Thr Arg Val Thr Thr Ser Asp
385                 390                 395                 400 
Glu Asp Ile Gly Ile Asn Ala Ile Ser Arg Tyr Ser Ile Met Asp Ala
                405                 410                 415     
Ser Leu Pro Phe Thr Ile Asn Pro Ser Thr Gly Asp Ile Val Ile Ser
            420                 425                 430         
Arg Pro Leu Asn Arg Glu Asp Thr Asp Arg Tyr Arg Ile Arg Val Ser
        435                 440                 445             
Ala His Asp Ser Gly Trp Thr Val Ser Thr Asp Val Thr Ile Phe Val
    450                 455                 460                 
Thr Asp Ile Asn Asp Asn Ala Pro Arg Phe Ser Arg Thr Ser Tyr Tyr
465                 470                 475                 480 
Leu Asp Cys Pro Glu Leu Thr Glu Ile Gly Ser Lys Val Thr Gln Val
                485                 490                 495     
Phe Ala Thr Asp Pro Asp Glu Gly Ser Asn Gly Gln Val Phe Tyr Phe
            500                 505                 510         
Ile Lys Ser Gln Ser Glu Tyr Phe Arg Ile Asn Ala Thr Thr Gly Glu
        515                 520                 525             
Ile Phe Asn Lys Gln Ile Leu Lys Tyr Gln Asn Val Thr Gly Phe Ser
    530                 535                 540                 
Asn Val Asn Ile Asn Arg His Ser Phe Ile Val Thr Ser Ser Asp Arg
545                 550                 555                 560 
Gly Lys Pro Ser Leu Ile Ser Glu Thr Thr Val Thr Ile Asn Ile Val
                565                 570                 575     
Asp Ser Asn Asp Asn Ala Pro Gln Phe Leu Lys Ser Lys Tyr Phe Thr
            580                 585                 590         
Pro Val Thr Lys Asn Val Lys Val Gly Thr Lys Leu Ile Arg Val Thr
        595                 600                 605             
Ala Ile Asp Asp Lys Asp Phe Gly Leu Asn Ser Glu Val Glu Tyr Phe
    610                 615                 620                 
Ile Ser Asn Asp Asn His Leu Gly Lys Phe Lys Leu Asp Asn Asp Thr
625                 630                 635                 640 
Gly Trp Ile Ser Val Ala Ser Ser Leu Ile Ser Asp Leu Asn Gln Asn
                645                 650                 655     
Phe Phe Ile Thr Val Thr Ala Lys Asp Lys Gly Asn Pro Pro Leu Ser
            660                 665                 670         
Ser Gln Ala Thr Val His Ile Thr Val Thr Glu Glu Asn Tyr His Thr
        675                 680                 685             
Pro Glu Phe Ser Gln Ser His Met Ser Ala Thr Ile Pro Glu Ser His
    690                 695                 700                 
Ser Ile Gly Ser Ile Val Arg Thr Val Ser Ala Arg Asp Arg Asp Ala
705                 710                 715                 720 
Ala Met Asn Gly Leu Ile Lys Tyr Ser Ile Ser Ser Gly Asn Glu Glu
                725                 730                 735     
Gly Ile Phe Ala Ile Asn Ser Ser Thr Gly Ile Leu Thr Leu Ala Lys
            740                 745                 750         
Ala Leu Asp Tyr Glu Leu Cys Gln Lys His Glu Met Thr Ile Ser Ala
        755                 760                 765             
Ile Asp Gly Gly Trp Val Ala Arg Thr Gly Tyr Cys Ser Val Thr Val
    770                 775                 780                 
Asn Val Ile Asp Val Asn Asp Asn Ser Pro Val Phe Leu Ser Asp Asp
785                 790                 795                 800 
Tyr Phe Pro Thr Val Leu Glu Asn Ala Pro Ser Gly Thr Thr Val Ile
                805                 810                 815     
His Leu Asn Ala Thr Asp Ala Asp Ser Gly Thr Asn Ala Val Ile Ala
            820                 825                 830         
Tyr Thr Val Gln Ser Ser Asp Ser Asp Leu Phe Val Ile Asp Pro Asn
        835                 840                 845             
Thr Gly Val Ile Thr Thr Gln Gly Phe Leu Asp Phe Glu Thr Lys Gln
    850                 855                 860                 
Ser Tyr His Leu Thr Val Lys Ala Phe Asn Val Pro Asp Glu Glu Arg
865                 870                 875                 880 
Cys Ser Phe Ala Thr Val Asn Ile Gln Leu Lys Gly Thr Asn Glu Tyr
                885                 890                 895     
Val Pro Arg Phe Val Ser Lys Leu Tyr Tyr Phe Glu Ile Ser Glu Ala
            900                 905                 910         
Ala Pro Lys Gly Thr Ile Val Gly Glu Val Phe Ala Ser Asp Arg Asp
        915                 920                 925             
Leu Gly Thr Asp Gly Glu Val His Tyr Leu Ile Phe Gly Asn Ser Arg
    930                 935                 940                 
Lys Lys Gly Phe Gln Ile Asn Lys Lys Thr Gly Gln Ile Tyr Val Ser
945                 950                 955                 960 
Gly Ile Leu Asp Arg Glu Lys Glu Glu Arg Val Ser Leu Lys Val Leu
                965                 970                 975     
Ala Lys Asn Phe Gly Ser Ile Arg Gly Ala Asp Ile Asp Glu Val Thr
            980                 985                 990         
Val Asn Val Thr Val Leu Asp Ala Asn Asp Pro Pro Ile Phe Thr Leu
        995                 1000                1005            
Asn Ile Tyr Ser Val Gln Ile Ser Glu Gly Val Pro Ile Gly Thr His
    1010                1015                1020                
Val Thr Phe Val Ser Ala Phe Asp Ser Asp Ser Ile Pro Ser Trp Ser
1025                1030                1035                1040
Arg Phe Ser Tyr Phe Ile Gly Ser Gly Asn Glu Asn Gly Ala Phe Ser
                1045                1050                1055    
Ile Asn Pro Gln Thr Gly Gln Ile Thr Val Thr Ala Glu Leu Asp Arg
            1060                1065                1070        
Glu Thr Leu Pro Ile Tyr Asn Leu Ser Val Leu Ala Val Asp Ser Gly
        1075                1080                1085            
Thr Pro Ser Ala Thr Gly Ser Ala Ser Leu Leu Val Thr Leu Glu Asp
    1090                1095                1100                
Ile Asn Asp Asn Gly Pro Met Leu Thr Val Ser Glu Gly Glu Val Met
1105                1110                1115                1120
Glu Asn Lys Arg Pro Gly Thr Leu Val Met Thr Leu Gln Ser Thr Asp
                1125                1130                1135    
Pro Asp Leu Pro Pro Asn Gln Gly Pro Phe Thr Tyr Tyr Leu Leu Ser
            1140                1145                1150        
Thr Gly Pro Ala Thr Ser Tyr Phe Ser Leu Ser Thr Ala Gly Val Leu
        1155                1160                1165            
Ser Thr Thr Arg Glu Ile Asp Arg Glu Gln Ile Ala Asp Phe Tyr Leu
    1170                1175                1180                
Ser Val Val Thr Lys Asp Ser Gly Val Pro Gln Met Ser Ser Thr Gly
1185                1190                1195                1200
Thr Val His Ile Thr Val Ile Asp Gln Asn Asp Asn Pro Ser Gln Ser
                1205                1210                1215    
Arg Thr Val Glu Ile Phe Val Asn Tyr Tyr Gly Asn Leu Phe Pro Gly
            1220                1225                1230        
Gly Ile Leu Gly Ser Val Lys Pro Gln Asp Pro Asp Val Leu Asp Ser
        1235                1240                1245            
Phe His Cys Ser Leu Thr Ser Gly Val Thr Ser Leu Phe Ser Ile Pro
    1250                1255                1260                
Gly Gly Thr Cys Asp Leu Asn Ser Gln Pro Arg Ser Thr Asp Gly Thr
1265                1270                1275                1280
Phe Asp Leu Thr Val Leu Ser Asn Asp Gly Val His Ser Thr Val Thr
                1285                1290                1295    
Ser Asn Ile Arg Val Phe Phe Ala Gly Phe Ser Asn Ala Thr Val Asp
            1300                1305                1310        
Asn Ser Ile Leu Leu Arg Leu Gly Val Pro Thr Val Lys Asp Phe Leu
        1315                1320                1325            
Thr Asn His Tyr Leu His Phe Leu Arg Ile Ala Ser Ser Gln Leu Thr
    1330                1335                1340                
Gly Leu Gly Thr Ala Val Gln Leu Tyr Ser Ala Tyr Glu Glu Asn Asn
1345                1350                1355                1360
Arg Thr Phe Leu Leu Ala Ala Val Lys Arg Asn His Asn Gln Tyr Val
                1365                1370                1375    
Asn Pro Ser Gly Val Ala Thr Phe Phe Glu Ser Ile Lys Glu Ile Leu
            1380                1385                1390        
Leu Arg Gln Ser Gly Val Lys Val Glu Ser Val Asp His Asp Ser Cys
        1395                1400                1405            
Val His Gly Pro Cys Gln Asn Gly Gly Ser Cys Leu Arg Arg Leu Ala
    1410                1415                1420                
Val Ser Ser Val Leu Lys Ser Arg Glu Ser Leu Pro Val Ile Ile Val
1425                1430                1435                1440
Ala Asn Glu Pro Leu Gln Pro Phe Leu Cys Lys Cys Leu Pro Gly Tyr
                1445                1450                1455    
Ala Gly Ser Trp Cys Glu Ile Asp Ile Asp Glu Cys Leu Pro Ser Pro
            1460                1465                1470        
Cys His Ser Gly Gly Thr Cys His Asn Leu Val Gly Gly Phe Ser Cys
        1475                1480                1485            
Ser Cys Pro Asp Gly Phe Thr Gly Arg Ala Cys Glu Arg Asp Ile Asn
    1490                1495                1500                
Glu Cys Leu Gln Ser Pro Cys Lys Asn Gly
1505                1510                


<210> 7172
<211> 1178
<212> PRT
<213> Homo sapiens

<400> 7172
Pro Leu Ser Ser Ser Thr Ser Val Leu Val Thr Val Thr Asp Val Asn
 1               5                  10                  15      
Asp Asn Pro Pro Arg Phe Gln His His Pro Tyr Val Thr His Ile Pro
            20                  25                  30          
Ser Pro Thr Leu Pro Gly Ser Phe Val Phe Ala Val Thr Val Thr Asp
        35                  40                  45              
Ala Asp Ile Gly Pro Asn Ser Glu Leu His Tyr Ser Leu Ser Gly Arg
    50                  55                  60                  
Asn Ser Glu Lys Phe His Ile Asp Pro Leu Arg Gly Ala Ile Met Ala
65                  70                  75                  80  
Ala Gly Pro Leu Asn Gly Ala Ser Glu Val Thr Phe Ser Val His Val
                85                  90                  95      
Lys Asp Gly Gly Ser Phe Pro Lys Thr Asp Ser Thr Thr Val Thr Val
            100                 105                 110         
Arg Phe Val Asn Lys Ala Asp Phe Pro Lys Val Arg Ala Lys Glu Gln
        115                 120                 125             
Thr Phe Met Phe Pro Glu Asn Gln Pro Val Ser Ser Leu Val Thr Thr
    130                 135                 140                 
Ile Thr Gly Ser Ser Leu Arg Gly Glu Pro Met Ser Tyr Tyr Ile Ala
145                 150                 155                 160 
Ser Gly Asn Leu Gly Asn Thr Phe Gln Ile Asp Gln Leu Thr Gly Gln
                165                 170                 175     
Val Ser Ile Ser Gln Pro Leu Asp Phe Glu Lys Ile Gln Lys Tyr Val
            180                 185                 190         
Val Trp Ile Glu Ala Arg Asp Gly Gly Phe Pro Pro Phe Ser Ser Tyr
        195                 200                 205             
Glu Lys Leu Asp Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro Ile
    210                 215                 220                 
Phe Lys Glu Asp Pro Phe Ile Ser Glu Ile Leu Glu Asn Leu Ser Pro
225                 230                 235                 240 
Arg Lys Ile Leu Thr Val Ser Ala Met Asp Lys Asp Ser Gly Pro Asn
                245                 250                 255     
Gly Gln Leu Asp Tyr Glu Ile Val Asn Gly Asn Met Glu Asn Ser Phe
            260                 265                 270         
Ser Ile Asn His Ala Thr Gly Glu Ile Arg Ser Val Arg Pro Leu Asp
        275                 280                 285             
Arg Glu Lys Val Ser His Tyr Val Leu Thr Ile Lys Ser Ser Asp Lys
    290                 295                 300                 
Gly Ser Pro Ser Gln Ser Thr Ser Val Lys Val Met Ile Asn Ile Leu
305                 310                 315                 320 
Asp Glu Asn Asp Asn Ala Pro Arg Phe Ser Gln Ile Phe Ser Ala His
                325                 330                 335     
Val Pro Glu Asn Ser Pro Leu Gly Tyr Thr Val Thr Arg Val Thr Thr
            340                 345                 350         
Ser Asp Glu Asp Ile Gly Ile Asn Ala Ile Ser Arg Tyr Ser Ile Met
        355                 360                 365             
Asp Ala Ser Leu Pro Phe Thr Ile Asn Pro Ser Thr Gly Asp Ile Val
    370                 375                 380                 
Ile Ser Arg Pro Leu Asn Arg Glu Asp Thr Asp Arg Tyr Arg Ile Arg
385                 390                 395                 400 
Val Ser Ala His Asp Ser Gly Trp Thr Val Ser Thr Asp Val Thr Ile
                405                 410                 415     
Phe Val Thr Asp Ile Asn Asp Asn Ala Pro Arg Phe Ser Arg Thr Ser
            420                 425                 430         
Tyr Tyr Leu Asp Cys Pro Glu Leu Thr Glu Ile Gly Ser Lys Val Thr
        435                 440                 445             
Gln Val Phe Ala Thr Asp Pro Asp Glu Gly Ser Asn Gly Gln Val Phe
    450                 455                 460                 
Tyr Phe Ile Lys Ser Gln Ser Glu Tyr Phe Arg Ile Asn Ala Thr Thr
465                 470                 475                 480 
Gly Glu Ile Phe Asn Lys Gln Ile Leu Lys Tyr Gln Asn Val Thr Gly
                485                 490                 495     
Phe Ser Asn Val Asn Ile Asn Arg His Ser Phe Ile Val Thr Ser Ser
            500                 505                 510         
Asp Arg Gly Lys Pro Ser Leu Ile Ser Glu Thr Thr Val Thr Ile Asn
        515                 520                 525             
Ile Val Asp Ser Asn Asp Asn Ala Pro Gln Phe Leu Lys Ser Lys Tyr
    530                 535                 540                 
Phe Thr Pro Val Thr Lys Asn Val Lys Val Gly Thr Lys Leu Ile Arg
545                 550                 555                 560 
Val Thr Ala Ile Asp Asp Lys Asp Phe Gly Leu Asn Ser Glu Val Glu
                565                 570                 575     
Tyr Phe Ile Ser Asn Asp Asn His Leu Gly Lys Phe Lys Leu Asp Asn
            580                 585                 590         
Asp Thr Gly Trp Ile Ser Val Ala Ser Ser Leu Ile Ser Asp Leu Asn
        595                 600                 605             
Gln Asn Phe Phe Ile Thr Val Thr Ala Lys Asp Lys Gly Asn Pro Pro
    610                 615                 620                 
Leu Ser Ser Gln Ala Thr Val His Ile Thr Val Thr Glu Glu Asn Tyr
625                 630                 635                 640 
His Thr Pro Glu Phe Ser Gln Ser His Met Ser Ala Thr Ile Pro Glu
                645                 650                 655     
Ser His Ser Ile Gly Ser Ile Val Arg Thr Val Ser Ala Arg Asp Arg
            660                 665                 670         
Asp Ala Ala Met Asn Gly Leu Ile Lys Tyr Ser Ile Ser Ser Gly Asn
        675                 680                 685             
Glu Glu Gly Ile Phe Ala Ile Asn Ser Ser Thr Gly Ile Leu Thr Leu
    690                 695                 700                 
Ala Lys Ala Leu Asp Tyr Glu Leu Cys Gln Lys His Glu Met Thr Ile
705                 710                 715                 720 
Ser Ala Ile Asp Gly Gly Trp Val Ala Arg Thr Gly Tyr Cys Ser Val
                725                 730                 735     
Thr Val Asn Val Ile Asp Val Asn Asp Asn Ser Pro Val Phe Leu Ser
            740                 745                 750         
Asp Asp Tyr Phe Pro Thr Val Leu Glu Asn Ala Pro Ser Gly Thr Thr
        755                 760                 765             
Val Ile His Leu Asn Ala Thr Asp Ala Asp Ser Gly Thr Asn Ala Val
    770                 775                 780                 
Ile Ala Phe Ser Tyr Phe Ile Gly Ser Gly Asn Glu Asn Gly Ala Phe
785                 790                 795                 800 
Ser Ile Asn Pro Gln Thr Gly Gln Ile Thr Val Thr Ala Glu Leu Asp
                805                 810                 815     
Arg Glu Thr Leu Pro Ile Tyr Asn Leu Ser Val Leu Ala Val Asp Ser
            820                 825                 830         
Gly Thr Pro Ser Ala Thr Gly Ser Ala Ser Leu Leu Val Thr Leu Glu
        835                 840                 845             
Asp Ile Asn Asp Asn Gly Pro Met Leu Thr Val Ser Glu Gly Glu Val
    850                 855                 860                 
Met Glu Asn Lys Arg Pro Gly Thr Leu Val Met Thr Leu Gln Ser Thr
865                 870                 875                 880 
Asp Pro Asp Leu Pro Pro Asn Gln Gly Pro Phe Thr Tyr Tyr Leu Leu
                885                 890                 895     
Ser Thr Gly Pro Ala Thr Ser Tyr Phe Ser Leu Ser Thr Ala Gly Val
            900                 905                 910         
Leu Ser Thr Thr Arg Glu Ile Asp Arg Glu Gln Ile Ala Asp Phe Tyr
        915                 920                 925             
Leu Ser Val Val Thr Lys Asp Ser Gly Val Pro Gln Met Ser Ser Thr
    930                 935                 940                 
Gly Thr Val His Ile Thr Val Ile Asp Gln Asn Asp Asn Pro Ser Gln
945                 950                 955                 960 
Ser Arg Thr Val Glu Ile Phe Val Asn Tyr Tyr Gly Asn Leu Phe Pro
                965                 970                 975     
Gly Gly Ile Leu Gly Ser Val Lys Pro Gln Asp Pro Asp Val Leu Asp
            980                 985                 990         
Ser Phe His Cys Ser Leu Thr Ser Gly Val Thr Ser Leu Phe Ser Ile
        995                 1000                1005            
Pro Gly Gly Thr Cys Asp Leu Asn Ser Gln Pro Arg Ser Thr Asp Gly
    1010                1015                1020                
Thr Phe Asp Leu Thr Val Leu Ser Asn Asp Gly Val His Ser Thr Val
1025                1030                1035                1040
Thr Ser Asn Ile Arg Val Phe Phe Ala Gly Phe Ser Asn Ala Thr Val
                1045                1050                1055    
Asp Asn Ser Ile Leu Leu Arg Leu Gly Val Pro Thr Val Lys Asp Phe
            1060                1065                1070        
Leu Thr Asn His Tyr Leu His Phe Leu Arg Ile Ala Ser Ser Gln Leu
        1075                1080                1085            
Thr Gly Leu Gly Thr Ala Val Gln Leu Tyr Ser Ala Tyr Glu Glu Asn
    1090                1095                1100                
Asn Arg Thr Phe Leu Leu Ala Ala Val Lys Arg Asn His Asn Gln Tyr
1105                1110                1115                1120
Val Asn Pro Ser Gly Val Ala Thr Phe Phe Glu Ser Ile Lys Glu Ile
                1125                1130                1135    
Leu Leu Arg Gln Ser Gly Val Lys Val Glu Ser Val Asp His Asp Ser
            1140                1145                1150        
Cys Val His Gly Pro Cys Gln Asn Gly Gly Ser Cys Leu Arg Arg Leu
        1155                1160                1165            
Ala Val Ser Ser Val Leu Lys Ser Arg Glu
    1170                1175            


<210> 7173
<211> 995
<212> PRT
<213> Homo sapiens

<400> 7173
Met Lys His Phe Cys Ser Ser Ser Val Ser Glu Asp Leu Gly Cys Arg
 1               5                  10                  15      
Arg Gly Asp Phe Ser Arg Lys His Tyr Gly Ser Val Glu Leu Leu Ile
            20                  25                  30          
Ser Ser Asp Ala Asp Gly Ala Ile Gln Arg Ala Gly Arg Phe Arg Val
        35                  40                  45              
Glu Asn Gly Ser Ser Asp Glu Asn Ala Thr Ala Leu Pro Gly Thr Trp
    50                  55                  60                  
Arg Arg Thr Asp Val His Leu Glu Asn Pro Glu Tyr His Thr Arg Trp
65                  70                  75                  80  
Tyr Phe Lys Tyr Phe Leu Gly Gln Val Arg Gln Asn Tyr Ile Gly Asn
                85                  90                  95      
Asp Ala Glu Lys Ser Pro Phe Phe Leu Ser Val Thr Leu Ser Asp Gln
            100                 105                 110         
Asn Asn Gln Arg Val Pro Gln Tyr Arg Ala Ile Leu Trp Arg Lys Thr
        115                 120                 125             
Gly Thr Gln Lys Ile Cys Leu Pro Tyr Ser Pro Thr Lys Thr Leu Ser
    130                 135                 140                 
Val Lys Ser Ile Leu Ser Ala Met Asn Leu Asp Lys Phe Glu Lys Gly
145                 150                 155                 160 
Pro Arg Glu Ile Phe His Pro Glu Ile Gln Lys Asp Leu Leu Val Leu
                165                 170                 175     
Glu Glu Gln Glu Gly Ser Val Asn Phe Lys Phe Gly Val Leu Phe Ala
            180                 185                 190         
Lys Asp Gly Gln Leu Thr Asp Asp Glu Met Phe Ser Asn Glu Ile Gly
        195                 200                 205             
Ser Glu Pro Phe Gln Lys Phe Leu Asn Leu Leu Gly Asp Thr Ile Thr
    210                 215                 220                 
Leu Lys Gly Trp Thr Gly Tyr Arg Gly Gly Leu Asp Thr Lys Asn Asp
225                 230                 235                 240 
Thr Thr Gly Ile His Ser Val Tyr Thr Val Tyr Gln Gly His Glu Ile
                245                 250                 255     
Met Phe His Val Ser Thr Met Leu Pro Tyr Ser Lys Glu Asn Lys Gln
            260                 265                 270         
Gln Val Glu Arg Lys Arg His Ile Gly Asn Asp Ile Val Thr Ile Val
        275                 280                 285             
Phe Gln Glu Gly Glu Glu Ser Ser Pro Ala Phe Lys Pro Ser Met Ile
    290                 295                 300                 
Arg Ser His Phe Thr His Ile Phe Ala Leu Val Arg Tyr Asn Gln Gln
305                 310                 315                 320 
Asn Asp Asn Tyr Arg Leu Lys Ile Phe Ser Glu Glu Ser Val Pro Leu
                325                 330                 335     
Phe Gly Pro Pro Leu Pro Thr Pro Pro Val Phe Thr Asp His Gln Glu
            340                 345                 350         
Phe Arg Asp Phe Leu Leu Val Lys Leu Ile Asn Gly Glu Lys Ala Thr
        355                 360                 365             
Leu Glu Thr Pro Thr Phe Ala Gln Lys Arg Arg Arg Thr Leu Asp Met
    370                 375                 380                 
Leu Ile Arg Ser Leu His Gln Asp Leu Met Pro Asp Leu His Lys Asn
385                 390                 395                 400 
Met Leu Asn Arg Arg Ser Phe Ser Asp Val Leu Pro Glu Ser Pro Lys
                405                 410                 415     
Ser Ala Arg Lys Lys Glu Glu Ala Arg Gln Ala Glu Phe Val Arg Ile
            420                 425                 430         
Gly Gln Ala Leu Lys Leu Lys Ser Ile Val Arg Gly Asp Ala Pro Ser
        435                 440                 445             
Ser Leu Ala Ala Ser Gly Ile Cys Lys Lys Glu Pro Trp Glu Pro Gln
    450                 455                 460                 
Cys Phe Cys Ser Asn Phe Pro His Glu Ala Val Cys Ala Asp Pro Trp
465                 470                 475                 480 
Gly Gln Ala Leu Leu Val Ser Thr Asp Ala Gly Val Leu Leu Val Asp
                485                 490                 495     
Asp Asp Leu Pro Ser Val Pro Val Phe Asp Arg Thr Leu Pro Val Lys
            500                 505                 510         
Gln Met His Val Leu Glu Thr Leu Asp Leu Leu Val Leu Arg Ala Asp
        515                 520                 525             
Lys Gly Lys Asp Ala Arg Leu Phe Val Phe Arg Leu Ser Ala Leu Gln
    530                 535                 540                 
Lys Gly Leu Glu Gly Lys Gln Ala Gly Lys Ser Arg Ser Asp Cys Arg
545                 550                 555                 560 
Glu Asn Lys Leu Glu Lys Thr Lys Gly Cys His Leu Tyr Ala Ile Asn
                565                 570                 575     
Thr His His Ser Arg Glu Leu Arg Ile Val Val Ala Ile Arg Asn Lys
            580                 585                 590         
Leu Leu Leu Ile Thr Arg Lys His Asn Lys Pro Ser Gly Val Thr Ser
        595                 600                 605             
Thr Ser Leu Leu Ser Pro Leu Ser Glu Ser Pro Val Glu Glu Phe Gln
    610                 615                 620                 
Tyr Ile Arg Glu Ile Cys Leu Ser Asp Ser Pro Met Val Met Thr Leu
625                 630                 635                 640 
Val Asp Gly Pro Ala Glu Glu Ser Asp Asn Leu Ile Cys Val Ala Tyr
                645                 650                 655     
Arg His Gln Phe Asp Val Val Asn Glu Ser Thr Gly Glu Ala Phe Arg
            660                 665                 670         
Leu His His Val Glu Ala Asn Arg Val Asn Phe Val Ala Ala Ile Asp
        675                 680                 685             
Val Tyr Glu Asp Gly Glu Ala Gly Leu Leu Leu Cys Tyr Asn Tyr Ser
    690                 695                 700                 
Cys Ile Tyr Lys Lys Val Cys Pro Phe Asn Gly Gly Ser Phe Leu Val
705                 710                 715                 720 
Gln Pro Ser Ala Ser Asp Phe Gln Phe Cys Trp Asn Gln Ala Pro Tyr
                725                 730                 735     
Ala Ile Val Cys Ala Phe Pro Tyr Leu Leu Ala Phe Thr Thr Asp Ser
            740                 745                 750         
Met Glu Ile Arg Leu Val Val Asn Gly Asn Leu Val His Thr Ala Val
        755                 760                 765             
Val Pro Gln Leu Gln Leu Val Ala Ser Arg Ser Asp Ile Tyr Phe Thr
    770                 775                 780                 
Ala Thr Ala Ala Val Asn Glu Val Ser Ser Gly Gly Ser Ser Lys Gly
785                 790                 795                 800 
Ala Ser Ala Arg Asn Ser Pro Gln Thr Pro Pro Gly Arg Asp Thr Pro
                805                 810                 815     
Val Phe Pro Ser Ser Leu Gly Glu Gly Glu Ile Gln Ser Lys Asn Leu
            820                 825                 830         
Tyr Lys Ile Pro Leu Arg Asn Leu Val Gly Arg Ser Ile Glu Arg Pro
        835                 840                 845             
Leu Lys Ser Pro Leu Val Ser Lys Val Ile Thr Pro Pro Thr Pro Ile
    850                 855                 860                 
Ser Val Gly Leu Ala Ala Ile Pro Val Thr His Ser Leu Ser Leu Ser
865                 870                 875                 880 
Arg Met Glu Ile Lys Glu Ile Ala Ser Arg Thr Arg Arg Glu Leu Leu
                885                 890                 895     
Gly Leu Ser Asp Glu Gly Gly Pro Lys Ser Glu Gly Ala Pro Lys Ala
            900                 905                 910         
Lys Ser Lys Pro Arg Lys Arg Leu Glu Glu Ser Gln Gly Gly Pro Lys
        915                 920                 925             
Pro Gly Ala Val Arg Ser Ser Ser Ser Asp Arg Ile Pro Ser Gly Ser
    930                 935                 940                 
Leu Glu Ser Ala Ser Thr Ser Glu Ala Asn Pro Glu Gly His Ser Ala
945                 950                 955                 960 
Ser Ser Asp Gln Asp Pro Val Ala Asp Arg Glu Gly Ser Pro Val Ser
                965                 970                 975     
Gly Ser Ser Pro Phe Gln Leu Thr Ala Phe Ser Asp Glu Asp Ile Ile
            980                 985                 990         
Asp Leu Lys
        995 


<210> 7174
<211> 423
<212> PRT
<213> Homo sapiens

<400> 7174
Met Val Val Asp Phe Cys Arg Arg Phe Val Ala Arg Ser Leu Cys Ile
 1               5                  10                  15      
Ile Leu Met Lys His Phe Cys Ser Ser Ser Val Ser Glu Asp Leu Gly
            20                  25                  30          
Cys Arg Arg Gly Asp Phe Ser Arg Lys His Tyr Gly Ser Val Glu Leu
        35                  40                  45              
Leu Ile Ser Ser Asp Ala Asp Gly Ala Ile Gln Arg Ala Gly Arg Phe
    50                  55                  60                  
Arg Val Glu Asn Gly Ser Ser Asp Glu Asn Ala Thr Ala Leu Pro Gly
65                  70                  75                  80  
Thr Trp Arg Arg Thr Asp Val His Leu Glu Asn Pro Glu Tyr His Thr
                85                  90                  95      
Arg Trp Tyr Phe Lys Tyr Phe Leu Gly Gln Val His Gln Asn Tyr Ile
            100                 105                 110         
Gly Asn Asp Ala Glu Lys Ser Pro Phe Phe Leu Ser Val Thr Leu Ser
        115                 120                 125             
Asp Gln Asn Asn Gln Arg Val Pro Gln Tyr Arg Ala Ile Leu Trp Arg
    130                 135                 140                 
Lys Thr Gly Thr Gln Lys Ile Cys Leu Pro Tyr Ser Pro Thr Lys Thr
145                 150                 155                 160 
Leu Ser Val Lys Ser Ile Leu Ser Ala Lys Asp Gly Gln Leu Thr Asp
                165                 170                 175     
Asp Glu Met Phe Ser Asn Glu Ile Gly Ser Glu Pro Phe Gln Lys Phe
            180                 185                 190         
Leu Asn Leu Leu Gly Asp Thr Ile Thr Leu Lys Gly Trp Thr Gly Tyr
        195                 200                 205             
Arg Gly Gly Leu Asp Thr Lys Asn Asp Thr Thr Gly Ile His Ser Val
    210                 215                 220                 
Tyr Thr Val Tyr Gln Gly His Glu Ile Met Phe His Val Ser Thr Met
225                 230                 235                 240 
Leu Pro Tyr Ser Lys Glu Asn Lys Gln Gln Val Glu Arg Lys Arg His
                245                 250                 255     
Ile Gly Asn Asp Ile Val Thr Ile Val Phe Gln Glu Gly Glu Glu Ser
            260                 265                 270         
Ser Pro Ala Phe Lys Pro Ser Met Ile Arg Ser His Phe Thr His Ile
        275                 280                 285             
Phe Ala Leu Val Arg Tyr Asn Gln Gln Asn Asp Asn Tyr Arg Leu Lys
    290                 295                 300                 
Ile Phe Ser Glu Glu Ser Val Pro Leu Phe Gly Pro Pro Leu Pro Thr
305                 310                 315                 320 
Pro Pro Val Phe Thr Asp His Gln Glu Phe Arg Asp Phe Leu Leu Val
                325                 330                 335     
Lys Leu Ile Asn Gly Glu Lys Ala Thr Leu Glu Thr Pro Thr Phe Ala
            340                 345                 350         
Gln Lys Arg Arg Arg Thr Leu Asp Met Leu Ile Arg Ser Leu His Gln
        355                 360                 365             
Asp Leu Met Pro Asp Leu His Lys Asn Met Leu Asn Arg Arg Ser Phe
    370                 375                 380                 
Ser Asp Val Leu Pro Glu Ser Pro Lys Ser Ala Arg Lys Lys Glu Glu
385                 390                 395                 400 
Ala Arg Gln Ala Glu Phe Val Arg Ile Gly Gln Val Gly Phe Leu Leu
                405                 410                 415     
Lys Pro Phe Leu Arg Asp Met
            420             


<210> 7175
<211> 69
<212> PRT
<213> Homo sapiens

<400> 7175
Met Asp Thr Ser His Val Gln Pro Ile Lys Leu Ala Arg Val Thr Glu
 1               5                  10                  15      
Val Leu Gly Arg Thr Gly Ser Gln Gly His Cys Thr Gln Val Arg Val
            20                  25                  30          
Glu Phe Met Asp Asn Thr Ser Arg Ser Ser Ile Arg Ser Val Lys Gly
        35                  40                  45              
Pro Val Cys Glu Gly Asp Val Leu Thr Leu Leu Glu Ser Glu Gln Glu
    50                  55                  60                  
Ala Trp Lys Leu Arg
65                  


<210> 7176
<211> 238
<212> PRT
<213> Homo sapiens

<400> 7176
Met Lys Lys Phe Leu Tyr Ile Lys Ser Val Phe His Thr Leu Arg Met
 1               5                  10                  15      
Ala Gln Arg Arg His Lys Arg Val Arg Thr Trp Thr Arg His Ile Asn
            20                  25                  30          
Ile Phe Asn Lys Asp Tyr Ile Phe Val Pro Val Asn Glu Ser Ser His
        35                  40                  45              
Trp Tyr Leu Ala Val Ile Cys Phe Pro Trp Leu Glu Glu Ala Val Tyr
    50                  55                  60                  
Glu Asp Phe Pro Gln Thr Val Ser Gln Gln Ser Gln Ala Gln Gln Ser
65                  70                  75                  80  
Gln Asn Asp Asn Lys Thr Ile Asp Asn Asp Leu Arg Thr Thr Ser Thr
                85                  90                  95      
Leu Ser Leu Ser Ala Glu Asp Ser Gln Ser Thr Glu Ser Asn Met Ser
            100                 105                 110         
Val Pro Lys Lys Met Cys Lys Arg Pro Cys Ile Leu Ile Leu Asp Ser
        115                 120                 125             
Leu Lys Ala Ala Ser Val Gln Asn Thr Val Gln Asn Leu Arg Glu Tyr
    130                 135                 140                 
Leu Glu Val Glu Trp Glu Val Lys Leu Lys Thr His Arg Gln Phe Ser
145                 150                 155                 160 
Lys Thr Asn Met Val Asp Leu Cys Pro Lys Val Pro Lys Gln Asp Asn
                165                 170                 175     
Ser Ser Asp Cys Gly Val Tyr Leu Leu Gln Tyr Val Glu Ser Phe Phe
            180                 185                 190         
Lys Asp Pro Ile Val Asn Phe Glu Leu Pro Ile His Leu Glu Lys Trp
        195                 200                 205             
Phe Pro Arg His Val Ile Lys Thr Lys Arg Glu Asp Ile Arg Glu Leu
    210                 215                 220                 
Ile Leu Lys Leu His Leu Gln Gln Gln Lys Gly Ser Ser Ser
225                 230                 235             


<210> 7177
<211> 984
<212> PRT
<213> Homo sapiens

<400> 7177
Met Asp Lys Arg Lys Leu Gly Arg Arg Pro Ser Ser Ser Glu Ile Ile
 1               5                  10                  15      
Thr Glu Gly Lys Arg Lys Lys Ser Ser Ser Asp Leu Ser Glu Ile Arg
            20                  25                  30          
Lys Met Leu Asn Ala Lys Pro Glu Asp Val His Val Gln Ser Pro Leu
        35                  40                  45              
Ser Lys Phe Arg Ser Ser Glu Arg Trp Thr Leu Pro Leu Gln Trp Glu
    50                  55                  60                  
Arg Ser Leu Arg Asn Lys Val Ile Ser Leu Asp His Lys Asn Lys Lys
65                  70                  75                  80  
His Ile Arg Gly Cys Pro Val Thr Ser Arg Ser Ser Pro Glu Arg Ile
                85                  90                  95      
Pro Arg Val Ile Leu Thr Asn Val Leu Gly Thr Glu Leu Gly Arg Lys
            100                 105                 110         
Tyr Ile Arg Thr Pro Pro Val Thr Glu Gly Ser Leu Ser Asp Thr Asp
        115                 120                 125             
Asn Leu Gln Ser Glu Gln Leu Ser Ser Ser Ser Asp Gly Ser Leu Glu
    130                 135                 140                 
Ser Tyr Gln Asn Leu Asn Pro His Lys Ser Cys Tyr Leu Ser Glu Arg
145                 150                 155                 160 
Gly Ser Gln Arg Ser Lys Thr Val Asp Asp Asn Ser Ala Lys Gln Thr
                165                 170                 175     
Ala His Asn Lys Glu Lys Arg Arg Lys Asp Asp Gly Ile Ser Leu Leu
            180                 185                 190         
Ile Ser Asp Thr Gln Pro Glu Asp Leu Asn Ser Gly Ser Arg Gly Cys
        195                 200                 205             
Asp His Leu Glu Gln Glu Ser Arg Asn Lys Asp Val Lys Tyr Ser Asp
    210                 215                 220                 
Ser Lys Val Glu Leu Thr Leu Ile Ser Arg Lys Thr Lys Arg Arg Leu
225                 230                 235                 240 
Arg Asn Asn Leu Pro Asp Ser Gln Tyr Cys Thr Ser Leu Asp Lys Ser
                245                 250                 255     
Thr Glu Gln Thr Lys Lys Gln Glu Asp Asp Ser Thr Ile Ser Thr Glu
            260                 265                 270         
Phe Glu Arg Pro Ser Glu Asn Tyr His Gln Asp Pro Lys Leu Pro Glu
        275                 280                 285             
Glu Ile Thr Thr Lys Pro Thr Lys Ser Asp Phe Thr Lys Leu Ser Ser
    290                 295                 300                 
Leu Asn Ser Gln Glu Leu Thr Leu Ser Asn Ala Thr Lys Ser Ala Ser
305                 310                 315                 320 
Ala Gly Ser Thr Thr Glu Thr Val Glu Tyr Ser Asn Ser Ile Asp Ile
                325                 330                 335     
Val Gly Ile Ser Ser Leu Val Glu Lys Asp Glu Asn Glu Leu Asn Thr
            340                 345                 350         
Ile Glu Lys Pro Ile Leu Arg Gly His Asn Glu Gly Asn Gln Ser Leu
        355                 360                 365             
Ile Ser Ala Glu Pro Ile Val Val Ser Ser Asp Glu Glu Gly Pro Val
    370                 375                 380                 
Glu His Lys Ser Ser Glu Ile Leu Lys Leu Gln Ser Lys Gln Asp Arg
385                 390                 395                 400 
Glu Thr Thr Asn Glu Asn Glu Ser Thr Ser Glu Ser Ala Leu Leu Glu
                405                 410                 415     
Leu Pro Leu Ile Thr Cys Glu Ser Val Gln Met Ser Ser Glu Leu Cys
            420                 425                 430         
Pro Tyr Asn Pro Val Met Glu Asn Ile Ser Ser Ile Met Pro Ser Asn
        435                 440                 445             
Glu Met Asp Leu Gln Leu Asp Phe Ile Phe Thr Ser Val Tyr Ile Gly
    450                 455                 460                 
Lys Ile Lys Gly Ala Ser Lys Gly Cys Val Thr Ile Thr Lys Lys Tyr
465                 470                 475                 480 
Ile Lys Ile Pro Phe Gln Val Ser Leu Asn Glu Ile Ser Leu Leu Val
                485                 490                 495     
Asp Thr Thr His Leu Lys Arg Phe Gly Leu Trp Lys Ser Lys Asp Asp
            500                 505                 510         
Asn His Ser Lys Arg Ser His Ala Ile Leu Phe Phe Trp Val Ser Ser
        515                 520                 525             
Asp Tyr Leu Gln Glu Ile Gln Thr Gln Leu Glu His Ser Val Leu Ser
    530                 535                 540                 
Gln Gln Ser Lys Ser Ser Glu Phe Ile Phe Leu Glu Leu His Asn Pro
545                 550                 555                 560 
Val Ser Gln Arg Glu Glu Leu Lys Leu Lys Asp Ile Met Thr Glu Ile
                565                 570                 575     
Ser Ile Ile Ser Gly Glu Leu Glu Leu Ser Tyr Pro Leu Ser Trp Val
            580                 585                 590         
Gln Ala Phe Pro Leu Phe Gln Asn Leu Ser Ser Lys Glu Ser Ser Phe
        595                 600                 605             
Ile His Tyr Tyr Cys Val Ser Thr Cys Ser Phe Pro Ala Gly Val Ala
    610                 615                 620                 
Val Ala Glu Glu Met Lys Leu Lys Ser Val Ser Gln Pro Ser Asn Thr
625                 630                 635                 640 
Asp Ala Ala Lys Pro Thr Tyr Thr Phe Leu Gln Lys Gln Ser Ser Gly
                645                 650                 655     
Cys Tyr Ser Leu Ser Ile Thr Ser Asn Pro Asp Glu Glu Trp Arg Glu
            660                 665                 670         
Val Arg His Thr Gly Leu Val Gln Lys Leu Ile Val Tyr Pro Pro Pro
        675                 680                 685             
Pro Thr Lys Gly Gly Leu Gly Val Thr Asn Glu Asp Leu Glu Cys Leu
    690                 695                 700                 
Glu Glu Gly Glu Phe Leu Asn Asp Val Ile Ile Asp Phe Tyr Leu Lys
705                 710                 715                 720 
Tyr Leu Ile Leu Glu Lys Ala Ser Asp Glu Leu Val Glu Arg Ser His
                725                 730                 735     
Ile Phe Ser Ser Phe Phe Tyr Lys Cys Leu Thr Arg Lys Glu Asn Asn
            740                 745                 750         
Leu Thr Glu Asp Asn Pro Asn Leu Ser Met Ala Gln Arg Arg His Lys
        755                 760                 765             
Arg Val Arg Thr Trp Thr Arg His Ile Asn Ile Phe Asn Lys Asp Tyr
    770                 775                 780                 
Ile Phe Val Pro Val Asn Glu Ser Ser His Trp Tyr Leu Ala Val Ile
785                 790                 795                 800 
Cys Phe Pro Trp Leu Glu Glu Ala Val Tyr Glu Asp Phe Pro Gln Thr
                805                 810                 815     
Val Ser Gln Gln Ser Gln Ala Gln Gln Ser Gln Asn Asp Asn Lys Thr
            820                 825                 830         
Ile Asp Asn Asp Leu Arg Thr Thr Ser Thr Leu Ser Leu Ser Ala Glu
        835                 840                 845             
Asp Ser Gln Ser Thr Glu Ser Asn Met Ser Val Pro Lys Lys Met Cys
    850                 855                 860                 
Lys Arg Pro Cys Ile Leu Ile Leu Asp Ser Leu Lys Ala Ala Ser Val
865                 870                 875                 880 
Gln Asn Thr Val Gln Asn Leu Arg Glu Tyr Leu Glu Val Glu Trp Glu
                885                 890                 895     
Val Lys Leu Lys Thr His Arg Gln Phe Ser Lys Thr Asn Met Val Asp
            900                 905                 910         
Leu Cys Pro Lys Val Pro Lys Gln Asp Asn Ser Ser Asp Cys Gly Val
        915                 920                 925             
Tyr Leu Leu Gln Tyr Val Glu Ser Phe Phe Lys Asp Pro Ile Val Asn
    930                 935                 940                 
Phe Glu Leu Pro Ile His Leu Glu Lys Trp Phe Pro Arg His Val Ile
945                 950                 955                 960 
Lys Thr Lys Arg Glu Asp Ile Arg Glu Leu Ile Leu Lys Leu His Leu
                965                 970                 975     
Gln Gln Gln Lys Gly Ser Ser Ser
            980                 


<210> 7178
<211> 886
<212> PRT
<213> Homo sapiens

<400> 7178
Met Leu Asn Ala Lys Pro Glu Asp Val His Val Gln Ser Pro Leu Ser
 1               5                  10                  15      
Lys Phe Arg Ser Ser Glu Arg Trp Thr Leu Pro Leu Gln Trp Glu Arg
            20                  25                  30          
Ser Leu Arg Asn Lys Val Ile Ser Leu Asp His Lys Asn Lys Lys His
        35                  40                  45              
Ile Arg Gly Cys Pro Val Thr Ser Lys Ser Ser Pro Glu Arg Gly Ser
    50                  55                  60                  
Gln Arg Ser Lys Thr Val Asp Asp Asn Ser Ala Lys Gln Thr Ala His
65                  70                  75                  80  
Asn Lys Glu Lys Arg Arg Lys Asp Asp Gly Ile Ser Leu Leu Ile Ser
                85                  90                  95      
Asp Thr Gln Pro Glu Asp Leu Asn Ser Gly Ser Arg Gly Cys Asp His
            100                 105                 110         
Leu Glu Gln Glu Ser Arg Asn Lys Asp Val Lys Tyr Ser Asp Ser Lys
        115                 120                 125             
Val Glu Leu Thr Leu Ile Ser Arg Lys Thr Lys Arg Arg Leu Arg Asn
    130                 135                 140                 
Asn Leu Pro Asp Ser Gln Tyr Cys Thr Ser Leu Asp Lys Ser Thr Glu
145                 150                 155                 160 
Gln Thr Lys Lys Gln Glu Asp Asp Ser Thr Ile Ser Thr Glu Phe Glu
                165                 170                 175     
Lys Pro Ser Glu Asn Tyr His Gln Asp Pro Lys Leu Pro Glu Glu Ile
            180                 185                 190         
Thr Thr Lys Pro Thr Lys Ser Asp Phe Thr Lys Leu Ser Ser Leu Asn
        195                 200                 205             
Ser Gln Glu Leu Thr Leu Ser Asn Ala Thr Lys Ser Ala Ser Ala Gly
    210                 215                 220                 
Ser Thr Thr Glu Thr Val Glu Asn Ser Asn Ser Ile Asp Ile Val Gly
225                 230                 235                 240 
Ile Ser Ser Leu Val Glu Lys Asp Glu Asn Glu Leu Asn Thr Ile Glu
                245                 250                 255     
Lys Pro Ile Leu Arg Gly His Asn Glu Gly Asn Gln Ser Leu Ile Ser
            260                 265                 270         
Ala Glu Pro Ile Val Val Ser Ser Asp Glu Glu Gly Pro Val Glu His
        275                 280                 285             
Lys Ser Ser Glu Ile Leu Lys Leu Gln Ser Lys Gln Asp Arg Glu Thr
    290                 295                 300                 
Thr Asn Glu Asn Glu Ser Thr Ser Glu Ser Ala Leu Leu Glu Leu Pro
305                 310                 315                 320 
Leu Ile Thr Cys Glu Ser Val Gln Met Ser Ser Glu Leu Cys Pro Tyr
                325                 330                 335     
Asn Pro Val Met Glu Asn Ile Ser Ser Ile Met Pro Ser Asn Glu Met
            340                 345                 350         
Asp Leu Gln Leu Asp Phe Ile Phe Thr Ser Val Tyr Ile Gly Lys Ile
        355                 360                 365             
Lys Gly Ala Ser Lys Gly Cys Val Thr Ile Thr Lys Lys Tyr Ile Lys
    370                 375                 380                 
Ile Pro Phe Gln Val Ser Leu Asn Glu Ile Ser Leu Leu Val Asp Thr
385                 390                 395                 400 
Thr His Leu Lys Arg Phe Gly Leu Trp Lys Ser Lys Asp Asp Asn His
                405                 410                 415     
Ser Lys Arg Ser His Ala Ile Leu Phe Phe Trp Val Ser Ser Asp Tyr
            420                 425                 430         
Leu Gln Glu Ile Gln Thr Gln Leu Glu His Ser Val Leu Ser Gln Gln
        435                 440                 445             
Ser Lys Ser Ser Glu Phe Ile Phe Leu Glu Leu His Asn Pro Val Ser
    450                 455                 460                 
Gln Arg Glu Glu Leu Lys Leu Lys Asp Ile Met Thr Glu Ile Ser Ile
465                 470                 475                 480 
Ile Ser Gly Glu Leu Glu Leu Ser Tyr Pro Leu Ser Trp Val Gln Ala
                485                 490                 495     
Phe Pro Leu Phe Gln Asn Leu Ser Ser Lys Glu Ser Ser Phe Ile His
            500                 505                 510         
Tyr Tyr Cys Val Ser Thr Cys Ser Phe Pro Ala Gly Val Ala Val Ala
        515                 520                 525             
Glu Glu Met Lys Leu Lys Ser Val Ser Gln Pro Ser Asn Thr Asp Ala
    530                 535                 540                 
Ala Lys Pro Thr Tyr Thr Phe Leu Gln Lys Gln Ser Ser Gly Cys Tyr
545                 550                 555                 560 
Ser Leu Ser Ile Thr Ser Asn Pro Asp Glu Glu Trp Arg Glu Val Arg
                565                 570                 575     
His Thr Gly Leu Val Gln Lys Leu Ile Val Tyr Pro Pro Pro Pro Thr
            580                 585                 590         
Lys Gly Gly Leu Gly Val Thr Asn Glu Asp Leu Glu Cys Leu Glu Glu
        595                 600                 605             
Gly Glu Phe Leu Asn Asp Val Ile Ile Asp Phe Tyr Leu Lys Tyr Leu
    610                 615                 620                 
Ile Leu Glu Lys Ala Ser Asp Glu Leu Val Glu Arg Ser His Ile Phe
625                 630                 635                 640 
Ser Ser Phe Phe Tyr Lys Cys Leu Thr Arg Lys Glu Asn Asn Leu Thr
                645                 650                 655     
Glu Asp Asn Pro Asn Leu Ser Met Ala Gln Arg Arg His Lys Arg Val
            660                 665                 670         
Arg Thr Trp Thr Arg His Ile Asn Ile Phe Asn Lys Asp Tyr Ile Phe
        675                 680                 685             
Val Pro Val Asn Glu Ser Ser His Trp Tyr Leu Ala Val Ile Cys Phe
    690                 695                 700                 
Pro Trp Leu Glu Glu Ala Val Tyr Glu Asp Phe Pro Gln Thr Val Ser
705                 710                 715                 720 
Gln Gln Ser Gln Ala Gln Gln Ser Gln Asn Asp Asn Lys Thr Ile Asp
                725                 730                 735     
Asn Asp Leu Arg Thr Thr Ser Thr Leu Ser Leu Ser Ala Glu Asp Ser
            740                 745                 750         
Gln Ser Thr Glu Ser Asn Met Ser Val Pro Lys Lys Met Cys Lys Arg
        755                 760                 765             
Pro Cys Ile Leu Ile Leu Asp Ser Leu Lys Ala Ala Ser Val Gln Asn
    770                 775                 780                 
Thr Val Gln Asn Leu Arg Glu Tyr Leu Glu Val Glu Trp Glu Val Lys
785                 790                 795                 800 
Leu Lys Thr His Arg Gln Phe Ser Lys Thr Asn Met Val Asp Leu Cys
                805                 810                 815     
Pro Lys Val Pro Lys Gln Asp Asn Ser Ser Asp Cys Gly Val Tyr Leu
            820                 825                 830         
Leu Gln Tyr Val Glu Ser Phe Phe Lys Asp Pro Ile Val Asn Phe Glu
        835                 840                 845             
Leu Pro Ile His Leu Glu Lys Trp Phe Pro Arg His Val Ile Lys Thr
    850                 855                 860                 
Lys Arg Glu Asp Ile Arg Glu Leu Ile Leu Lys Leu His Leu Gln Gln
865                 870                 875                 880 
Gln Lys Gly Ser Ser Ser
                885     


<210> 7179
<211> 1017
<212> PRT
<213> Homo sapiens

<400> 7179
Met Leu Asn Ala Lys Pro Glu Asp Val His Val Gln Ser Pro Leu Ser
 1               5                  10                  15      
Lys Phe Arg Ser Ser Glu Arg Trp Thr Leu Pro Leu Gln Trp Glu Arg
            20                  25                  30          
Ser Leu Arg Asn Lys Val Ile Ser Leu Asp His Lys Asn Lys Lys His
        35                  40                  45              
Ile Arg Gly Cys Pro Val Thr Ser Arg Ser Ser Pro Glu Arg Gln Leu
    50                  55                  60                  
Lys Val Met Leu Thr Asn Val Leu Trp Thr Asp Leu Gly Arg Lys Phe
65                  70                  75                  80  
Arg Lys Thr Leu Pro Arg Asn Asp Ala Asn Leu Cys Asp Ala Asn Lys
                85                  90                  95      
Val Gln Ser Asp Ser Leu Pro Ser Thr Ser Val Asp Ser Leu Glu Thr
            100                 105                 110         
Cys Gln Lys Leu Glu Pro Leu Arg Gln Ser Leu Asn Leu Ser Glu Arg
        115                 120                 125             
Ile Pro Arg Val Ile Leu Thr Asn Val Leu Gly Thr Glu Leu Gly Arg
    130                 135                 140                 
Lys Tyr Ile Arg Thr Pro Pro Val Thr Glu Gly Ser Leu Ser Asp Thr
145                 150                 155                 160 
Asp Asn Leu Gln Ser Glu Gln Leu Ser Ser Ser Ser Asp Gly Ser Leu
                165                 170                 175     
Glu Ser Tyr Gln Asn Leu Asn Pro His Lys Ser Cys Tyr Leu Ser Glu
            180                 185                 190         
Arg Gly Ser Gln Arg Ser Lys Thr Val Asp Asp Asn Ser Ala Lys Gln
        195                 200                 205             
Thr Ala His Asn Lys Glu Lys Arg Arg Lys Asp Asp Gly Ile Ser Leu
    210                 215                 220                 
Leu Ile Ser Asp Thr Gln Pro Glu Asp Leu Asn Ser Gly Ser Arg Gly
225                 230                 235                 240 
Cys Asp His Leu Glu Gln Glu Ser Arg Asn Lys Asp Val Lys Tyr Ser
                245                 250                 255     
Asp Ser Lys Val Glu Leu Thr Leu Ile Ser Arg Lys Thr Lys Arg Arg
            260                 265                 270         
Leu Arg Asn Asn Leu Pro Asp Ser Gln Tyr Cys Thr Ser Leu Asp Lys
        275                 280                 285             
Ser Thr Glu Gln Thr Lys Lys Gln Glu Asp Asp Ser Thr Ile Ser Thr
    290                 295                 300                 
Glu Phe Glu Arg Pro Ser Glu Asn Tyr His Gln Asp Pro Lys Leu Pro
305                 310                 315                 320 
Glu Glu Ile Thr Thr Lys Pro Thr Lys Ser Asp Phe Thr Lys Leu Ser
                325                 330                 335     
Ser Leu Asn Ser Gln Glu Leu Thr Leu Ser Asn Ala Thr Lys Ser Ala
            340                 345                 350         
Ser Ala Gly Ser Thr Thr Glu Thr Val Glu Tyr Ser Asn Ser Ile Asp
        355                 360                 365             
Ile Val Gly Ile Ser Ser Leu Val Glu Lys Asp Glu Asn Glu Leu Asn
    370                 375                 380                 
Thr Ile Glu Lys Pro Ile Leu Arg Gly His Asn Glu Gly Asn Gln Ser
385                 390                 395                 400 
Leu Ile Ser Ala Glu Pro Ile Val Val Ser Ser Asp Glu Glu Gly Pro
                405                 410                 415     
Val Glu His Lys Ser Ser Glu Ile Leu Lys Leu Gln Ser Lys Gln Asp
            420                 425                 430         
Arg Glu Thr Thr Asn Glu Asn Glu Ser Thr Ser Glu Ser Ala Leu Leu
        435                 440                 445             
Glu Leu Pro Leu Ile Thr Cys Glu Ser Val Gln Met Ser Ser Glu Leu
    450                 455                 460                 
Cys Pro Tyr Asn Pro Val Met Glu Asn Ile Ser Ser Ile Met Pro Ser
465                 470                 475                 480 
Asn Glu Met Asp Leu Gln Leu Asp Phe Ile Phe Thr Ser Val Tyr Ile
                485                 490                 495     
Gly Lys Ile Lys Gly Ala Ser Lys Gly Cys Val Thr Ile Thr Lys Lys
            500                 505                 510         
Tyr Ile Lys Ile Pro Phe Gln Val Ser Leu Asn Glu Ile Ser Leu Leu
        515                 520                 525             
Val Asp Thr Thr His Leu Lys Arg Phe Gly Leu Trp Lys Ser Lys Asp
    530                 535                 540                 
Asp Asn His Ser Lys Arg Ser His Ala Ile Leu Phe Phe Trp Val Ser
545                 550                 555                 560 
Ser Asp Tyr Leu Gln Glu Ile Gln Thr Gln Leu Glu His Ser Val Leu
                565                 570                 575     
Ser Gln Gln Ser Lys Ser Ser Glu Phe Ile Phe Leu Glu Leu His Asn
            580                 585                 590         
Pro Val Ser Gln Arg Glu Glu Leu Lys Leu Lys Asp Ile Met Thr Glu
        595                 600                 605             
Ile Ser Ile Ile Ser Gly Glu Leu Glu Leu Ser Tyr Pro Leu Ser Trp
    610                 615                 620                 
Val Gln Ala Phe Pro Leu Phe Gln Asn Leu Ser Ser Lys Glu Ser Ser
625                 630                 635                 640 
Phe Ile His Tyr Tyr Cys Val Ser Thr Cys Ser Phe Pro Ala Gly Val
                645                 650                 655     
Ala Val Ala Glu Glu Met Lys Leu Lys Ser Val Ser Gln Pro Ser Asn
            660                 665                 670         
Thr Asp Ala Ala Lys Pro Thr Tyr Thr Phe Leu Gln Lys Gln Ser Ser
        675                 680                 685             
Gly Cys Tyr Ser Leu Ser Ile Thr Ser Asn Pro Asp Glu Glu Trp Arg
    690                 695                 700                 
Glu Val Arg His Thr Gly Leu Val Gln Lys Leu Ile Val Tyr Pro Pro
705                 710                 715                 720 
Pro Pro Thr Lys Gly Gly Leu Gly Val Thr Asn Glu Asp Leu Glu Cys
                725                 730                 735     
Leu Glu Glu Gly Glu Phe Leu Asn Asp Val Ile Ile Asp Phe Tyr Leu
            740                 745                 750         
Lys Tyr Leu Ile Leu Glu Lys Ala Ser Asp Glu Leu Val Glu Arg Ser
        755                 760                 765             
His Ile Phe Ser Ser Phe Phe Tyr Lys Cys Leu Thr Arg Lys Glu Asn
    770                 775                 780                 
Asn Leu Thr Glu Asp Asn Pro Asn Leu Ser Met Ala Gln Arg Arg His
785                 790                 795                 800 
Lys Arg Val Arg Thr Trp Thr Arg His Ile Asn Ile Phe Asn Lys Asp
                805                 810                 815     
Tyr Ile Phe Val Pro Val Asn Glu Ser Ser His Trp Tyr Leu Ala Val
            820                 825                 830         
Ile Cys Phe Pro Trp Leu Glu Glu Ala Val Tyr Glu Asp Phe Pro Gln
        835                 840                 845             
Thr Val Ser Gln Gln Ser Gln Ala Gln Gln Ser Gln Asn Asp Asn Lys
    850                 855                 860                 
Thr Ile Asp Asn Asp Leu Arg Thr Thr Ser Thr Leu Ser Leu Ser Ala
865                 870                 875                 880 
Glu Asp Ser Gln Ser Thr Glu Ser Asn Met Ser Val Pro Lys Lys Met
                885                 890                 895     
Cys Lys Arg Pro Cys Ile Leu Ile Leu Asp Ser Leu Lys Ala Ala Ser
            900                 905                 910         
Val Gln Asn Thr Val Gln Asn Leu Arg Glu Tyr Leu Glu Val Glu Trp
        915                 920                 925             
Glu Val Lys Leu Lys Thr His Arg Gln Phe Ser Lys Thr Asn Met Val
    930                 935                 940                 
Asp Leu Cys Pro Lys Val Pro Lys Gln Asp Asn Ser Ser Asp Cys Gly
945                 950                 955                 960 
Val Tyr Leu Leu Gln Tyr Val Glu Ser Phe Phe Lys Asp Pro Ile Val
                965                 970                 975     
Asn Phe Glu Leu Pro Ile His Leu Glu Lys Trp Phe Pro Arg His Val
            980                 985                 990         
Ile Lys Thr Lys Arg Glu Asp Ile Arg Glu Leu Ile Leu Lys Leu His
        995                 1000                1005            
Leu Gln Gln Gln Lys Gly Ser Ser Ser
    1010                1015        


<210> 7180
<211> 572
<212> PRT
<213> Homo sapiens

<400> 7180
Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg
 1               5                  10                  15      
Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr
            20                  25                  30          
Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn
        35                  40                  45              
Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met
    50                  55                  60                  
Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp
65                  70                  75                  80  
Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala
                85                  90                  95      
Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro
            100                 105                 110         
Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp
        115                 120                 125             
Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp
    130                 135                 140                 
His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly
145                 150                 155                 160 
Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu
                165                 170                 175     
Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly
            180                 185                 190         
Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu
        195                 200                 205             
Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val
    210                 215                 220                 
Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile
225                 230                 235                 240 
Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met
                245                 250                 255     
Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr
            260                 265                 270         
Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser
        275                 280                 285             
His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser
    290                 295                 300                 
Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu
305                 310                 315                 320 
Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe
                325                 330                 335     
Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro
            340                 345                 350         
Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys
        355                 360                 365             
Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr
    370                 375                 380                 
Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg
385                 390                 395                 400 
Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser
                405                 410                 415     
Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn
            420                 425                 430         
Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser
        435                 440                 445             
Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly
    450                 455                 460                 
Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys
465                 470                 475                 480 
Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg
                485                 490                 495     
Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr
            500                 505                 510         
Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala
        515                 520                 525             
Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala
    530                 535                 540                 
Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala
545                 550                 555                 560 
Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly
                565                 570         


<210> 7181
<211> 636
<212> PRT
<213> Homo sapiens

<400> 7181
Ala Ser Phe Gly Val Arg Pro Gly Cys Cys Ser Gly Asp Gln Leu Val
 1               5                  10                  15      
Ser Leu Gly Gly Arg Cys Phe Pro Arg Pro Pro Gly Ala Met Ile Gln
            20                  25                  30          
Asn Val Gly Asn His Leu Arg Arg Gly Leu Ala Ser Val Phe Ser Asn
        35                  40                  45              
Arg Thr Ser Arg Lys Ser Ala Leu Arg Ala Gly Asn Asp Ser Ala Met
    50                  55                  60                  
Ala Asp Gly Glu Gly Tyr Arg Asn Pro Thr Glu Val Gln Met Ser Gln
65                  70                  75                  80  
Leu Val Leu Pro Cys His Thr Asn Gln Arg Gly Glu Leu Ser Val Gly
                85                  90                  95      
Gln Leu Leu Lys Trp Ile Asp Thr Thr Ala Cys Leu Ser Ala Glu Arg
            100                 105                 110         
His Ala Gly Cys Pro Cys Val Thr Ala Ser Met Asp Asp Ile Tyr Phe
        115                 120                 125             
Glu His Thr Ile Ser Val Gly Gln Val Val Asn Ile Lys Ala Lys Val
    130                 135                 140                 
Asn Arg Ala Phe Asn Ser Ser Met Glu Val Gly Ile Gln Val Ala Ser
145                 150                 155                 160 
Glu Asp Leu Cys Ser Glu Lys Gln Trp Asn Val Cys Lys Ala Leu Ala
                165                 170                 175     
Thr Phe Val Ala Arg Arg Glu Ile Thr Lys Val Lys Leu Lys Gln Ile
            180                 185                 190         
Thr Pro Arg Thr Glu Glu Glu Lys Met Glu His Ser Val Ala Ala Glu
        195                 200                 205             
Arg Arg Arg Met Arg Leu Val Tyr Ala Asp Thr Ile Lys Asp Leu Leu
    210                 215                 220                 
Ala Asn Cys Ala Ile Gln Gly Asp Leu Glu Ser Arg Asp Cys Ser Arg
225                 230                 235                 240 
Met Val Pro Ala Glu Lys Thr Arg Val Glu Ser Val Glu Leu Val Leu
                245                 250                 255     
Pro Pro His Ala Asn His Gln Gly Asn Thr Phe Gly Gly Gln Ile Met
            260                 265                 270         
Ala Trp Met Glu Asn Val Ala Thr Ile Ala Ala Ser Arg Leu Cys Arg
        275                 280                 285             
Ala His Pro Thr Leu Lys Ala Ile Glu Met Phe His Phe Arg Gly Pro
    290                 295                 300                 
Ser Gln Val Gly Asp Arg Leu Val Leu Lys Ala Ile Val Asn Asn Ala
305                 310                 315                 320 
Phe Lys His Ser Met Glu Val Gly Val Cys Val Glu Ala Tyr Arg Gln
                325                 330                 335     
Glu Ala Glu Thr His Arg Arg His Ile Asn Ser Ala Phe Met Thr Phe
            340                 345                 350         
Val Val Leu Asp Ala Asp Asp Gln Pro Gln Leu Leu Pro Trp Ile Arg
        355                 360                 365             
Pro Gln Pro Gly Asp Gly Glu Arg Arg Tyr Arg Glu Ala Ser Ala Arg
    370                 375                 380                 
Lys Lys Ile Arg Leu Asp Arg Lys Tyr Ile Val Ser Cys Lys Gln Thr
385                 390                 395                 400 
Glu Val Pro Leu Ser Val Pro Trp Asp Pro Ser Asn Gln Val Tyr Leu
                405                 410                 415     
Ser Tyr Asn Asn Val Ser Ser Leu Lys Met Leu Val Ala Lys Asp Asn
            420                 425                 430         
Trp Val Leu Ser Ser Glu Ile Ser Gln Val Arg Leu Tyr Thr Leu Glu
        435                 440                 445             
Asp Asp Lys Phe Leu Ser Phe His Met Glu Met Val Val His Val Asp
    450                 455                 460                 
Ala Ala Gln Ala Phe Leu Leu Leu Ser Asp Leu Arg Gln Arg Pro Glu
465                 470                 475                 480 
Trp Asp Lys His Tyr Arg Ser Val Glu Leu Val Gln Gln Val Asp Glu
                485                 490                 495     
Asp Asp Ala Ile Tyr His Val Thr Ser Pro Ala Leu Gly Gly His Thr
            500                 505                 510         
Lys Pro Gln Asp Phe Val Ile Leu Ala Ser Arg Arg Lys Pro Cys Asp
        515                 520                 525             
Asn Gly Asp Pro Tyr Val Ile Ala Leu Arg Ser Val Thr Leu Pro Thr
    530                 535                 540                 
His Arg Glu Thr Pro Glu Tyr Arg Arg Gly Glu Thr Leu Cys Ser Gly
545                 550                 555                 560 
Phe Cys Leu Trp Arg Glu Gly Asp Gln Leu Thr Lys Cys Cys Trp Val
                565                 570                 575     
Arg Val Ser Leu Thr Glu Leu Val Ser Ala Ser Gly Phe Tyr Ser Trp
            580                 585                 590         
Gly Leu Glu Ser Arg Ser Lys Gly Arg Arg Ser Asp Gly Trp Asn Gly
        595                 600                 605             
Lys Leu Ala Gly Gly His Leu Ser Thr Leu Lys Ala Ile Pro Val Ala
    610                 615                 620                 
Lys Ile Asn Ser Arg Phe Gly Tyr Leu Gln Asp Thr
625                 630                 635     


<210> 7182
<211> 594
<212> PRT
<213> Homo sapiens

<400> 7182
Met Ile Gln Asn Val Gly Asn His Leu Arg Arg Gly Leu Ala Ser Val
 1               5                  10                  15      
Phe Ser Asn Arg Thr Ser Arg Lys Ser Ala Leu Arg Ala Gly Asn Asp
            20                  25                  30          
Ser Ala Met Ala Asp Gly Glu Gly Tyr Arg Asn Pro Thr Glu Val Gln
        35                  40                  45              
Met Ser Gln Leu Val Leu Pro Cys His Thr Asn Gln Arg Gly Glu Leu
    50                  55                  60                  
Ser Val Gly Gln Leu Leu Lys Trp Ile Asp Thr Thr Ala Cys Leu Ser
65                  70                  75                  80  
Ala Glu Arg His Ala Gly Cys Pro Cys Val Thr Ala Ser Met Asp Asp
                85                  90                  95      
Ile Tyr Phe Glu His Thr Ile Ser Val Gly Gln Val Val Asn Ile Lys
            100                 105                 110         
Ala Lys Val Asn Arg Ala Phe Asn Ser Ser Met Glu Val Gly Ile Gln
        115                 120                 125             
Val Ala Ser Glu Asp Leu Cys Ser Glu Lys Gln Trp Asn Val Cys Lys
    130                 135                 140                 
Ala Leu Ala Thr Phe Val Ala Arg Arg Glu Ile Thr Lys Val Lys Leu
145                 150                 155                 160 
Lys Gln Ile Thr Pro Arg Thr Glu Glu Glu Lys Met Glu His Ser Val
                165                 170                 175     
Ala Ala Glu Arg Arg Arg Met Arg Leu Val Tyr Ala Asp Thr Ile Lys
            180                 185                 190         
Asp Leu Leu Ala Asn Cys Ala Ile Gln Gly Asp Leu Glu Ser Arg Asp
        195                 200                 205             
Cys Ser Arg Met Val Pro Ala Glu Lys Thr Arg Val Glu Ser Val Glu
    210                 215                 220                 
Leu Val Leu Pro Pro His Ala Asn His Gln Gly Asn Thr Phe Gly Gly
225                 230                 235                 240 
Gln Ile Met Ala Trp Met Glu Asn Val Ala Thr Ile Ala Ala Ser Arg
                245                 250                 255     
Leu Cys Arg Ala His Pro Thr Leu Lys Ala Ile Glu Met Phe His Phe
            260                 265                 270         
Arg Gly Pro Ser Gln Val Gly Asp Arg Leu Val Leu Lys Ala Ile Val
        275                 280                 285             
Asn Asn Ala Phe Lys His Ser Met Glu Val Gly Val Cys Val Glu Ala
    290                 295                 300                 
Tyr Arg Gln Glu Ala Glu Thr His Arg Arg His Ile Asn Ser Ala Phe
305                 310                 315                 320 
Met Thr Phe Val Val Leu Asp Ala Asp Asp Gln Pro Gln Leu Leu Pro
                325                 330                 335     
Trp Ile Arg Pro Gln Pro Gly Asp Gly Glu Arg Arg Tyr Arg Glu Ala
            340                 345                 350         
Ser Ala Arg Lys Lys Ile Arg Leu Asp Arg Lys Tyr Ile Val Ser Cys
        355                 360                 365             
Lys Gln Thr Glu Val Pro Leu Ser Val Pro Trp Asp Pro Ser Asn Gln
    370                 375                 380                 
Val Tyr Leu Ser Tyr Asn Asn Val Ser Ser Leu Lys Met Leu Val Ala
385                 390                 395                 400 
Lys Asp Asn Trp Val Leu Ser Ser Glu Ile Ser Gln Val Arg Leu Tyr
                405                 410                 415     
Thr Leu Glu Asp Asp Lys Phe Leu Ser Phe His Met Glu Met Val Val
            420                 425                 430         
His Val Asp Ala Ala Gln Ala Phe Leu Leu Leu Ser Asp Leu Arg Gln
        435                 440                 445             
Arg Pro Glu Trp Asp Lys His Tyr Arg Ser Val Glu Leu Val Gln Gln
    450                 455                 460                 
Val Asp Glu Asp Asp Ala Ile Tyr His Val Thr Ser Pro Ala Leu Gly
465                 470                 475                 480 
Gly His Thr Lys Pro Gln Asp Phe Val Ile Leu Ala Ser Arg Arg Lys
                485                 490                 495     
Pro Cys Asp Asn Gly Asp Pro Tyr Val Ile Ala Leu Arg Ser Val Thr
            500                 505                 510         
Leu Pro Thr His Arg Glu Thr Pro Glu Tyr Arg Arg Gly Glu Thr Leu
        515                 520                 525             
Cys Ser Gly Phe Cys Leu Trp Arg Glu Gly Asp Gln Leu Thr Lys Val
    530                 535                 540                 
Ser Tyr Tyr Asn Gln Ala Thr Pro Gly Val Leu Asn Tyr Val Thr Thr
545                 550                 555                 560 
Asn Val Ala Gly Leu Ser Ser Glu Phe Tyr Thr Thr Phe Lys Ala Cys
                565                 570                 575     
Glu Gln Phe Leu Leu Asp Asn Arg Asn Asp Leu Ala Pro Ser Leu Gln
            580                 585                 590         
Thr Leu
        


<210> 7183
<211> 651
<212> PRT
<213> Homo sapiens

<400> 7183
Met Ile Ala Thr Val Asp Leu Lys Val Asn Glu Tyr Glu Lys Asn Gln
 1               5                  10                  15      
Lys Trp Leu Glu Ile Leu Asn Lys Ile Glu Asn Lys Thr Tyr Thr Lys
            20                  25                  30          
Leu Lys Asn Gly His Val Phe Arg Lys Gln Ala Leu Met Ser Glu Glu
        35                  40                  45              
Arg Thr Leu Leu Tyr Asp Gly Leu Val Tyr Trp Lys Thr Ala Thr Gly
    50                  55                  60                  
Arg Phe Lys Asp Ile Leu Ala Leu Leu Leu Thr Asp Val Leu Leu Phe
65                  70                  75                  80  
Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ala Val Asp Gln Lys
                85                  90                  95      
Pro Ser Val Ile Ser Leu Gln Lys Leu Ile Ala Arg Glu Val Ala Asn
            100                 105                 110         
Glu Glu Arg Gly Met Phe Leu Ile Ser Ala Ser Ser Ala Gly Pro Glu
        115                 120                 125             
Met Tyr Glu Ile His Thr Asn Ser Lys Glu Glu Arg Asn Asn Trp Met
    130                 135                 140                 
Arg Arg Ile Gln Gln Ala Val Glu Ser Cys Pro Glu Glu Lys Gly Gly
145                 150                 155                 160 
Arg Thr Ser Glu Ser Asp Glu Asp Lys Arg Lys Ala Glu Ala Arg Val
                165                 170                 175     
Ala Lys Ile Gln Gln Cys Gln Glu Ile Leu Thr Asn Gln Asp Gln Gln
            180                 185                 190         
Ile Cys Ala Tyr Leu Glu Glu Lys Leu His Ile Tyr Ala Glu Leu Gly
        195                 200                 205             
Glu Leu Ser Gly Phe Glu Asp Val His Leu Glu Pro His Leu Leu Ile
    210                 215                 220                 
Lys Pro Asp Pro Gly Glu Pro Pro Gln Ala Ala Ser Leu Leu Ala Ala
225                 230                 235                 240 
Ala Leu Lys Glu Ala Leu Val Thr Gly Gly Arg Glu Gly Arg Gly Cys
                245                 250                 255     
Ser Asp Val Asp Pro Gly Ile Gln Gly Val Val Thr Asp Leu Ala Val
            260                 265                 270         
Ser Asp Ala Gly Glu Lys Val Glu Cys Arg Asn Phe Pro Gly Ser Ser
        275                 280                 285             
Gln Ser Glu Ile Ile Gln Ala Ile Gln Asn Leu Thr Arg Leu Leu Tyr
    290                 295                 300                 
Ser Leu Gln Ala Ala Leu Thr Ile Gln Asp Ser His Ile Glu Ile His
305                 310                 315                 320 
Arg Leu Val Leu Gln Gln Gln Glu Gly Leu Ser Leu Gly His Ser Ile
                325                 330                 335     
Leu Arg Gly Gly Pro Leu Gln Asp Gln Lys Ser Arg Asp Ala Asp Arg
            340                 345                 350         
Gln His Glu Glu Leu Ala Asn Val His Gln Leu Gln His Gln Leu Gln
        355                 360                 365             
Gln Gly Gln Arg Arg Trp Leu Arg Arg Cys Glu Gln Gln Gln Arg Ala
    370                 375                 380                 
Gln Ala Thr Arg Glu Ser Trp Leu Gln Glu Arg Glu Arg Glu Cys Gln
385                 390                 395                 400 
Ser Gln Glu Glu Leu Leu Leu Arg Ser Arg Gly Glu Leu Asp Leu Gln
                405                 410                 415     
Leu Gln Glu Tyr Gln His Ser Leu Glu Arg Leu Arg Glu Gly Gln Arg
            420                 425                 430         
Leu Val Glu Arg Glu Gln Ala Arg Met Arg Ala Gln Gln Ser Leu Leu
        435                 440                 445             
Gly His Trp Lys His Gly Arg Gln Arg Ser Leu Ser Ala Val Leu Leu
    450                 455                 460                 
Pro Gly Gly Pro Glu Val Met Glu Leu Asn Arg Ser Glu Ser Leu Cys
465                 470                 475                 480 
His Glu Asn Ser Phe Phe Ile Asn Glu Ala Leu Val Gln Met Ser Phe
                485                 490                 495     
Asn Thr Phe Asn Lys Leu Asn Pro Ser Val Ile His Gln Asp Ala Thr
            500                 505                 510         
Tyr Pro Thr Thr Gln Ser His Ser Asp Leu Val Arg Thr Ser Glu His
        515                 520                 525             
Gln Val Asp Leu Lys Val Asp Pro Ser Gln Pro Ser Asn Val Ser His
    530                 535                 540                 
Lys Leu Trp Thr Ala Ala Gly Ser Gly His Gln Ile Leu Pro Phe His
545                 550                 555                 560 
Glu Ser Ser Lys Asp Ser Cys Lys Asn Gly Ser Ser Met Thr Lys Cys
                565                 570                 575     
Ser Cys Thr Leu Thr Ser Pro Pro Gly Leu Trp Thr Gly Thr Thr Ser
            580                 585                 590         
Thr Leu Lys Asp Leu Asp Thr Ser His Thr Glu Ser Pro Thr Pro His
        595                 600                 605             
Asp Ser Asn Ser His Arg Pro Gln Leu Gln Ala Phe Ile Thr Glu Ala
    610                 615                 620                 
Lys Leu Asn Leu Pro Thr Arg Thr Met Thr Arg Gln Asp Gly Glu Thr
625                 630                 635                 640 
Gly Asp Gly Ala Lys Glu Asn Ile Val Tyr Leu
                645                 650     


<210> 7184
<211> 669
<212> PRT
<213> Homo sapiens

<400> 7184
Met Ile Ala Thr Val Asp Leu Lys Val Asn Glu Tyr Glu Lys Asn Gln
 1               5                  10                  15      
Lys Trp Leu Glu Ile Leu Asn Lys Ile Glu Asn Lys Thr Tyr Thr Lys
            20                  25                  30          
Leu Lys Asn Gly His Val Phe Arg Lys Gln Ala Leu Met Ser Glu Glu
        35                  40                  45              
Arg Thr Leu Leu Tyr Asp Gly Leu Val Tyr Trp Lys Thr Ala Thr Gly
    50                  55                  60                  
Arg Phe Lys Asp Ile Leu Ala Leu Leu Leu Thr Asp Val Leu Leu Phe
65                  70                  75                  80  
Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ala Val Asp Gln Lys
                85                  90                  95      
Pro Ser Val Ile Ser Leu Gln Lys Leu Ile Ala Arg Glu Val Ala Asn
            100                 105                 110         
Glu Glu Arg Gly Met Phe Leu Ile Ser Ala Ser Ser Ala Gly Pro Glu
        115                 120                 125             
Met Tyr Glu Ile His Thr Asn Ser Lys Glu Glu Arg Asn Asn Trp Met
    130                 135                 140                 
Arg Arg Ile Gln Gln Ala Val Glu Ser Cys Pro Glu Glu Lys Gly Gly
145                 150                 155                 160 
Arg Thr Ser Glu Ser Asp Glu Asp Lys Arg Lys Ala Glu Ala Arg Val
                165                 170                 175     
Ala Lys Ile Gln Gln Cys Gln Glu Ile Leu Thr Asn Gln Asp Gln Gln
            180                 185                 190         
Ile Cys Ala Tyr Leu Glu Glu Lys Leu His Ile Tyr Ala Glu Leu Gly
        195                 200                 205             
Glu Leu Ser Gly Phe Glu Asp Val His Leu Glu Pro His Leu Leu Ile
    210                 215                 220                 
Lys Pro Asp Pro Gly Glu Pro Pro Gln Ala Ala Ser Leu Leu Ala Ala
225                 230                 235                 240 
Ala Leu Lys Glu Ala Glu Ser Leu Gln Val Ala Val Lys Ala Ser Gln
                245                 250                 255     
Met Gly Ala Val Ser Gln Ser Cys Glu Asp Ser Cys Gly Asp Ser Val
            260                 265                 270         
Leu Ala Asp Thr Leu Ser Ser His Asp Val Pro Gly Ser Pro Thr Ala
        275                 280                 285             
Ser Leu Val Thr Gly Gly Arg Glu Gly Arg Gly Cys Ser Asp Val Asp
    290                 295                 300                 
Pro Gly Ile Gln Gly Val Val Thr Asp Leu Ala Val Ser Asp Ala Gly
305                 310                 315                 320 
Glu Lys Val Glu Cys Arg Asn Phe Pro Gly Ser Ser Gln Ser Glu Ile
                325                 330                 335     
Ile Gln Ala Ile Gln Asn Leu Thr Arg Leu Leu Tyr Ser Leu Gln Ala
            340                 345                 350         
Ala Leu Thr Ile Gln Asp Ser His Ile Glu Ile His Arg Leu Val Leu
        355                 360                 365             
Gln Gln Gln Glu Gly Leu Ser Leu Gly His Ser Ile Leu Arg Gly Gly
    370                 375                 380                 
Pro Leu Gln Asp Gln Lys Ser Arg Asp Ala Asp Arg Gln His Glu Glu
385                 390                 395                 400 
Leu Ala Asn Val His Gln Leu Gln His Gln Leu Gln Gln Glu Gln Arg
                405                 410                 415     
Arg Trp Leu Arg Arg Cys Glu Gln Gln Gln Arg Ala Gln Ala Thr Arg
            420                 425                 430         
Glu Ser Trp Leu Gln Glu Arg Glu Arg Glu Cys Gln Ser Gln Glu Glu
        435                 440                 445             
Leu Leu Leu Arg Ser Arg Gly Glu Leu Asp Leu Gln Leu Gln Glu Tyr
    450                 455                 460                 
Gln His Ser Leu Glu Arg Leu Arg Glu Gly Gln Arg Leu Val Glu Arg
465                 470                 475                 480 
Glu Gln Ala Arg Met Arg Ala Gln Gln Ser Leu Leu Gly His Trp Lys
                485                 490                 495     
His Gly Arg Gln Arg Ser Leu Pro Ala Val Leu Leu Pro Gly Gly Pro
            500                 505                 510         
Glu Val Met Glu Leu Asn Arg Ser Glu Ser Leu Cys His Glu Asn Ser
        515                 520                 525             
Phe Phe Ile Asn Glu Ala Leu Val Gln Met Ser Phe Asn Thr Phe Asn
    530                 535                 540                 
Lys Leu Asn Pro Ser Val Ile His Gln Asp Ala Thr Tyr Pro Thr Thr
545                 550                 555                 560 
Gln Ser His Ser Asp Leu Val Arg Thr Ser Glu His Gln Val Asp Leu
                565                 570                 575     
Lys Val Asp Pro Ser Gln Pro Ser Asn Val Ser His Lys Leu Trp Thr
            580                 585                 590         
Ala Ala Gly Ser Gly His Gln Ile Leu Pro Phe Gln Glu Ser Ser Lys
        595                 600                 605             
Asp Ser Cys Lys Asn Asp Leu Asp Thr Ser His Thr Glu Ser Pro Thr
    610                 615                 620                 
Pro His Asp Ser Asn Ser His Arg Pro Gln Leu Gln Ala Phe Ile Thr
625                 630                 635                 640 
Glu Ala Lys Leu Asn Leu Pro Thr Arg Thr Met Thr Arg Gln Asp Gly
                645                 650                 655     
Glu Thr Gly Asp Gly Ala Lys Glu Asn Ile Val Tyr Leu
            660                 665                 


<210> 7185
<211> 226
<212> PRT
<213> Homo sapiens

<400> 7185
Met Asp Pro Ala Val Ala Trp Gly Tyr Lys Leu Ala Ser Arg Val Leu
 1               5                  10                  15      
Lys Gln Leu Ala Ser Gly Val Ala Ala Leu Gly Val Arg Ser Arg Thr
            20                  25                  30          
Gln Asn Leu Ser Gln Pro Ser Thr Gly Ile Pro Ser Gly Glu Pro Gly
        35                  40                  45              
His Ser Ala Gly Gly Ala Ala Gly Ser Arg Cys Thr Arg Ser Met Phe
    50                  55                  60                  
Arg Lys Val Pro Asn Asn Ala Ser Ala Leu Ile Gly Ser Glu Leu Glu
65                  70                  75                  80  
His Gly Cys Ser Arg Gln Gly Gly Gly Cys Ser Pro Gln Pro Gly Val
                85                  90                  95      
Gln Pro Ser Thr His Leu Ser Pro Pro Glu Ser Cys Ser Ile Gly Ser
            100                 105                 110         
Ser Val Leu Trp Ala Leu Trp Ser His Pro Gln Arg Glu Gly Phe Gly
        115                 120                 125             
Val Thr Ser Val Gly Gln Leu His Lys Gly Pro Ala Cys Leu Cys Val
    130                 135                 140                 
Tyr Pro Gly Asp Cys Arg Met Ala His Ala Glu Gln Lys Leu Met Asp
145                 150                 155                 160 
Asp Leu Leu Asn Lys Thr Arg Tyr Asn Asn Leu Ile Cys Pro Ala Thr
                165                 170                 175     
Ser Ser Ser Gln Leu Ile Ser Ile Glu Thr Glu Leu Ser Leu Ala Gln
            180                 185                 190         
Cys Ile Ser Val Leu Ala Gln Gln Val Thr Leu Gln Ala Pro Tyr Leu
        195                 200                 205             
Leu Gly Glu Ile Arg Thr Lys Leu Gly Glu Leu Thr Gly Thr Val Ala
    210                 215                 220                 
Gln Val
225     


<210> 7186
<211> 548
<212> PRT
<213> Homo sapiens

<400> 7186
Gly Ser Val Ser Phe Ser Asp Val Ala Val Gly Phe Thr Gln Glu Glu
 1               5                  10                  15      
Trp Gln His Leu Asp Ser Ala Gln Arg Thr Pro Tyr Arg Asp Met Met
            20                  25                  30          
Leu Glu Asn Tyr Ser Leu Leu Leu Ser Val Gly Tyr Cys Ile Thr Lys
        35                  40                  45              
Pro Glu Val Val Cys Lys Leu Glu His Gly Gln Val Leu Trp Ile Leu
    50                  55                  60                  
Glu Glu Glu Ser Pro Ser Gln Ser His Leu Glu Leu Ile Ile Ser Asn
65                  70                  75                  80  
Arg Ser Ser Phe Val Arg Asn Pro Ala Glu Cys Asn Val Arg Gly Lys
                85                  90                  95      
Phe Leu Leu Cys Met Lys Arg Glu Asn Pro Tyr Ala Arg Gly Lys Pro
            100                 105                 110         
Leu Glu Tyr Asp Gly Asn Gly Lys Ala Val Ser Gln Asn Glu Asp Leu
        115                 120                 125             
Phe Arg His Gln Tyr Ile Gln Thr Leu Lys Gln Cys Phe Glu Tyr Asn
    130                 135                 140                 
Gln Cys Gly Lys Ala Phe His Glu Glu Ala Ala Cys Ser Thr His Lys
145                 150                 155                 160 
Arg Cys Ala His Gly Arg Pro Cys Glu Tyr Asn Glu His Val Arg Ala
                165                 170                 175     
Phe Ser Asp Arg Pro Ile Phe Ile Val His Gln Arg Thr His Ile Arg
            180                 185                 190         
Lys Ser His His Glu Phe Asn Glu Cys Glu Arg Arg Ser Gly Glu Arg
        195                 200                 205             
Pro Phe Glu Cys Asn Glu Cys Gln Lys Ser Phe Ser Val Lys Ser Lys
    210                 215                 220                 
Leu Arg Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys
225                 230                 235                 240 
Asn Glu Cys Glu Lys Met Phe Tyr His Lys Ser Ser Leu Thr Val His
                245                 250                 255     
Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Ser Glu Cys Gly
            260                 265                 270         
Lys Thr Phe Tyr Gln Lys Ser Ser Leu Thr Thr His Gln Arg Thr His
        275                 280                 285             
Thr Arg Glu Gln Pro Tyr Glu Tyr Asn Glu Ser Phe Tyr Gln Asn Pro
    290                 295                 300                 
Asn Phe Thr Lys Tyr Phe Thr Tyr His Gln Arg Thr His Thr Gly Glu
305                 310                 315                 320 
Arg Pro Cys Glu Cys Asn Glu Cys Gly Lys Ser Phe Ser Val Lys Ser
                325                 330                 335     
Lys Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu
            340                 345                 350         
Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Lys Ser Ser Leu Thr Val
        355                 360                 365             
His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Ala Cys
    370                 375                 380                 
Gly Lys Ser Phe Ser Gln Lys Lys Asn Ser Ile Leu Leu Ser His Gln
385                 390                 395                 400 
Arg Ile His Thr Gly Gln Lys Pro Tyr Lys Cys Asn Asp Cys Gly Lys
                405                 410                 415     
Ala Phe Ala Gln Asn Ala Ala Leu Thr Arg His Glu Arg Ile His Ser
            420                 425                 430         
Gly Glu Lys Pro Phe Lys Cys Asn Lys Cys Gly Arg Ala Phe Arg Asp
        435                 440                 445             
Asn Ser Thr Val Leu Glu His Gln Lys Ile His Thr Gly Glu Lys Pro
    450                 455                 460                 
Tyr Gln Cys Asn Glu Cys Gly Lys Ala Phe Arg Lys Ser Ser Thr Leu
465                 470                 475                 480 
Ile Ser His Gln Arg Met His Thr Gly Glu Lys Pro Tyr His Cys Ser
                485                 490                 495     
Lys Cys Gly Lys Ser Phe Arg Tyr Ser Ser Ser Phe Ala Gly His Gln
            500                 505                 510         
Lys Thr His Ser Gly Asn Lys Pro Tyr Gln Cys Arg Asp Cys Gly Lys
        515                 520                 525             
Ala Phe Thr Lys Ser Ser Thr Leu Thr Gly His Gln Arg Ile His Thr
    530                 535                 540                 
Gly Glu Lys Pro
545             


<210> 7187
<211> 647
<212> PRT
<213> Homo sapiens

<400> 7187
Ser Val Ser Phe Ser Asp Val Ala Val Gly Phe Thr Gln Glu Glu Trp
 1               5                  10                  15      
Gln His Leu Asp Ser Ala Gln Arg Thr Pro Tyr Arg Asp Met Met Leu
            20                  25                  30          
Glu Asn Tyr Ser Leu Leu Leu Ser Val Gly Tyr Cys Ile Thr Lys Pro
        35                  40                  45              
Glu Val Val Cys Lys Leu Glu His Gly Gln Val Leu Trp Ile Leu Glu
    50                  55                  60                  
Glu Glu Ser Pro Ser Gln Ser His Leu Asp Cys Cys Ile Asp Asp Asp
65                  70                  75                  80  
Leu Met Glu Lys Arg Gln Glu Asn Gln Asp Gln His Leu Gln Lys Val
                85                  90                  95      
Asp Phe Val Asn Asn Lys Thr Leu Thr Met Asp Arg Asn Gly Val Leu
            100                 105                 110         
Gly Lys Thr Phe Ser Leu Asp Thr Asn Pro Ile Leu Ser Arg Lys Ile
        115                 120                 125             
Arg Gly Asn Cys Asp Ser Ser Gly Met Asn Leu Asn Asn Ile Ser Glu
    130                 135                 140                 
Leu Ile Ile Ser Asn Arg Ser Ser Phe Val Arg Asn Pro Ala Glu Cys
145                 150                 155                 160 
Asn Val Arg Gly Lys Phe Leu Leu Cys Met Lys Arg Glu Asn Pro Tyr
                165                 170                 175     
Ala Arg Gly Lys Pro Leu Glu Tyr Asp Gly Asn Gly Lys Ala Val Ser
            180                 185                 190         
Gln Asn Glu Asp Leu Phe Arg His Gln Tyr Ile Gln Thr Leu Lys Gln
        195                 200                 205             
Cys Phe Glu Tyr Asn Gln Cys Gly Lys Ala Phe His Glu Glu Ala Ala
    210                 215                 220                 
Cys Ser His Ala Leu Gln Tyr Ile Lys Glu His Thr Arg Asp Lys Thr
225                 230                 235                 240 
Tyr Glu Cys Asn Glu Cys Gly Lys Asn Phe Cys Glu Lys Ser Asn Leu
                245                 250                 255     
His Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gly Cys Asn
            260                 265                 270         
Glu Cys Gln Lys Ala Phe Gly Asp Arg Ser Ala Leu Lys Val His Gln
        275                 280                 285             
Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys
    290                 295                 300                 
Thr Phe Ser Gln Lys Pro Asn Phe Ile Asn His Gln Gly Arg Val Leu
305                 310                 315                 320 
Lys Pro Lys Pro Leu Cys Thr His Lys Arg Val Cys Phe Trp Glu Lys
                325                 330                 335     
Pro Cys Glu Tyr Asn Glu Gln Leu Arg Ala Phe Ser Asp Asn Pro Asn
            340                 345                 350         
Leu Leu Val His Gln Asn Phe Thr Tyr His Gln Arg Thr His Thr Gly
        355                 360                 365             
Glu Arg Pro Cys Glu Cys Asn Glu Cys Gly Lys Ser Phe Ser Val Lys
    370                 375                 380                 
Ser Lys Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr
385                 390                 395                 400 
Glu Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Lys Ser Ser Leu Thr
                405                 410                 415     
Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Ala
            420                 425                 430         
Cys Gly Lys Ser Phe Ser Gln Lys Lys Asn Ser Ile Leu Leu Ser His
        435                 440                 445             
Gln Arg Ile His Thr Gly Gln Lys Pro Tyr Lys Cys Asn Asp Cys Gly
    450                 455                 460                 
Lys Ala Phe Ala Gln Asn Ala Ala Leu Thr Arg His Glu Arg Ile His
465                 470                 475                 480 
Ser Gly Glu Lys Pro Phe Lys Cys Asn Lys Cys Gly Arg Ala Phe Arg
                485                 490                 495     
Asp Asn Ser Thr Val Leu Glu His Gln Lys Ile His Thr Gly Glu Lys
            500                 505                 510         
Pro Tyr Gln Cys Asn Glu Cys Gly Lys Ala Phe Arg Lys Ser Ser Thr
        515                 520                 525             
Leu Ile Ser His Gln Arg Met His Thr Gly Glu Lys Pro Tyr His Cys
    530                 535                 540                 
Ser Lys Cys Gly Lys Ser Phe Arg Tyr Ser Ser Ser Phe Ala Gly His
545                 550                 555                 560 
Gln Lys Thr His Ser Gly Asn Lys Pro Tyr Gln Cys Arg Asp Cys Gly
                565                 570                 575     
Lys Ala Phe Thr Lys Ser Ser Thr Leu Thr Gly His Gln Arg Ile His
            580                 585                 590         
Thr Gly Glu Lys Pro Tyr His Cys Lys Lys Cys Gly Lys Ala Phe Arg
        595                 600                 605             
His Ser Ser Gly Leu Val Glu His Gln Arg Leu His Thr Gly Glu Lys
    610                 615                 620                 
Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Pro Arg Ser Ser Ala
625                 630                 635                 640 
Leu Lys Gln His Lys Lys Ile
                645         


<210> 7188
<211> 527
<212> PRT
<213> Homo sapiens

<400> 7188
Ser Val Ser Phe Ser Asp Val Ala Val Gly Phe Thr Gln Glu Glu Trp
 1               5                  10                  15      
Gln His Leu Asp Ser Ala Gln Arg Thr Pro Tyr Arg Asp Met Met Leu
            20                  25                  30          
Glu Asn Tyr Ser Leu Leu Leu Ser Val Gly Tyr Cys Ile Thr Lys Pro
        35                  40                  45              
Glu Val Val Cys Lys Leu Glu His Gly Gln Val Leu Trp Ile Leu Glu
    50                  55                  60                  
Glu Glu Ser Pro Ser Gln Ser His Leu Val His Phe Ala Val Ser Gln
65                  70                  75                  80  
Ser Ile Leu Tyr Ile Arg Lys Gln Ile Gln Lys Lys Asn Ser Met Asn
                85                  90                  95      
Val Val Asn Val Gly Lys Pro Ser Ala Ile Asn Pro Leu Leu Ser Tyr
            100                 105                 110         
Ser Arg Gly Tyr Thr Glu Glu Arg Asn Pro Met Asn Ala Leu Asn Val
        115                 120                 125             
Gly Lys Leu Leu Asp Ile Gly His Ala Leu Gln Tyr Ile Lys Glu His
    130                 135                 140                 
Thr Arg Asp Lys Thr Tyr Glu Cys Asn Glu Cys Gly Lys Asn Phe Cys
145                 150                 155                 160 
Glu Lys Ser Asn Leu His Val His Gln Arg Thr His Thr Gly Glu Lys
                165                 170                 175     
Pro Tyr Gly Cys Asn Glu Cys Gln Lys Ala Phe Gly Asp Arg Ser Ala
            180                 185                 190         
Leu Lys Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Tyr
        195                 200                 205             
Phe Thr Tyr His Gln Arg Thr His Thr Gly Glu Arg Pro Cys Glu Cys
    210                 215                 220                 
Asn Glu Cys Gly Lys Ser Phe Ser Val Lys Ser Lys Leu Ile Val His
225                 230                 235                 240 
Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly
                245                 250                 255     
Lys Thr Phe Ser Gln Lys Ser Ser Leu Thr Val His Gln Arg Thr His
            260                 265                 270         
Thr Gly Glu Lys Pro Tyr Lys Cys Asn Ala Cys Gly Lys Ser Phe Ser
        275                 280                 285             
Gln Asn Ser Ser Leu Leu Asn His His Lys Val His Ala Gly Lys Gln
    290                 295                 300                 
Pro Tyr Arg Cys Ile Glu Cys Gly Lys Phe Leu Lys Lys His Ser Thr
305                 310                 315                 320 
Phe Ile Asn His Gln Arg Ile His Ser Arg Glu Lys Pro His Lys Cys
                325                 330                 335     
Ile Glu Cys Gly Lys Thr Phe Arg Lys Asn Ser Ile Leu Leu Ser His
            340                 345                 350         
Gln Arg Ile His Thr Gly Gln Lys Pro Tyr Lys Cys Asn Asp Cys Gly
        355                 360                 365             
Lys Ala Phe Ala Gln Asn Ala Ala Leu Thr Arg His Glu Arg Ile His
    370                 375                 380                 
Ser Gly Glu Lys Pro Phe Lys Cys Asn Lys Cys Gly Arg Ala Phe Arg
385                 390                 395                 400 
Asp Asn Ser Thr Val Leu Glu His Gln Lys Ile His Thr Gly Glu Lys
                405                 410                 415     
Pro Tyr Gln Cys Asn Glu Cys Gly Lys Ala Phe Arg Lys Ser Ser Thr
            420                 425                 430         
Leu Ile Ser His Gln Arg Met His Thr Gly Glu Lys Pro Tyr His Cys
        435                 440                 445             
Ser Lys Cys Gly Lys Ser Phe Arg Tyr Ser Ser Ser Phe Ala Gly His
    450                 455                 460                 
Gln Lys Thr His Ser Gly Asn Lys Pro Tyr Gln Cys Arg Asp Cys Gly
465                 470                 475                 480 
Lys Ala Phe Thr Lys Ser Ser Thr Leu Thr Gly His Gln Arg Ile His
                485                 490                 495     
Thr Gly Glu Lys Pro Tyr His Cys Lys Lys Cys Gly Lys Ala Phe Arg
            500                 505                 510         
His Ser Ser Gly Leu Val Glu His Gln Arg Leu His Thr Gly Glu
        515                 520                 525         


<210> 7189
<211> 354
<212> PRT
<213> Homo sapiens

<400> 7189
Ser Val Ser Phe Ser Asp Val Ala Val Gly Phe Thr Gln Glu Glu Trp
 1               5                  10                  15      
Gln His Leu Asp Ser Ala Gln Arg Thr Pro Tyr Arg Asp Met Met Leu
            20                  25                  30          
Glu Asn Tyr Ser Leu Leu Leu Ser Val Gly Tyr Cys Ile Ser Lys Pro
        35                  40                  45              
Lys Val Val Phe Lys Leu Gln Gln Gly Glu Glu Ala Trp Ile Leu Glu
    50                  55                  60                  
Glu Glu Ser Ser Ser Gln Ser His Phe Gly Glu Tyr Glu Lys Pro His
65                  70                  75                  80  
Lys Cys Lys Glu Cys Gly Ile Ala Phe Met Asn Ser Ser Ser Leu Leu
                85                  90                  95      
Asn His His Lys Val His Ala Gly Lys Gln Pro Tyr Arg Cys Ile Glu
            100                 105                 110         
Cys Gly Lys Phe Leu Lys Lys His Ser Thr Phe Ile Asn His Gln Arg
        115                 120                 125             
Ile His Ser Arg Glu Lys Pro His Lys Cys Ile Glu Cys Gly Lys Thr
    130                 135                 140                 
Phe Arg Lys Asn Ser Ile Leu Leu Ser His Gln Arg Ile His Thr Gly
145                 150                 155                 160 
Gln Lys Pro Tyr Lys Cys Asn Asp Cys Gly Lys Ala Phe Ala Gln Asn
                165                 170                 175     
Ala Ala Leu Thr Arg His Glu Arg Ile His Ser Gly Glu Lys Pro Phe
            180                 185                 190         
Lys Cys Asn Lys Cys Gly Arg Ala Phe Arg Asp Asn Ser Thr Val Leu
        195                 200                 205             
Glu His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Asn Glu
    210                 215                 220                 
Cys Gly Lys Ala Phe Arg Lys Ser Ser Thr Leu Ile Ser His Gln Arg
225                 230                 235                 240 
Met His Thr Gly Glu Lys Pro Tyr His Cys Ser Lys Cys Gly Lys Ser
                245                 250                 255     
Phe Arg Tyr Ser Ser Ser Phe Ala Gly His Gln Lys Thr His Ser Gly
            260                 265                 270         
Asn Lys Pro Tyr Gln Cys Arg Asp Cys Gly Lys Ala Phe Thr Lys Ser
        275                 280                 285             
Ser Thr Leu Thr Gly His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
    290                 295                 300                 
His Cys Lys Lys Cys Gly Lys Ala Phe Arg His Ser Ser Gly Leu Val
305                 310                 315                 320 
Glu His Gln Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu
                325                 330                 335     
Cys Gly Lys Ala Phe Pro Arg Ser Ser Ala Leu Lys Gln His Lys Lys
            340                 345                 350         
Ile His
        


<210> 7190
<211> 518
<212> PRT
<213> Homo sapiens

<400> 7190
Gly Ser Val Ser Phe Ser Asp Val Ala Val Gly Phe Thr Gln Glu Glu
 1               5                  10                  15      
Trp Gln His Leu Asp Ser Ala Gln Arg Thr Pro Tyr Arg Asp Met Met
            20                  25                  30          
Leu Glu Asn Tyr Ser Leu Leu Leu Ser Val Gly Tyr Cys Ile Thr Lys
        35                  40                  45              
Pro Glu Val Val Cys Lys Leu Glu His Gly Gln Val Leu Trp Ile Leu
    50                  55                  60                  
Glu Glu Glu Ser Pro Ser Gln Ser His Leu Asp Asp Asp Leu Met Glu
65                  70                  75                  80  
Lys Arg Gln Glu Asn Gln Asp Gln His Leu Gln Lys Val Asp Phe Val
                85                  90                  95      
Asn Asn Lys Thr Leu Thr Met Asp Arg Asn Gly Val Leu Gly Lys Thr
            100                 105                 110         
Phe Ser Leu Asp Thr Asn Pro Ile Leu Ser Arg Lys Ile Arg Gly Asn
        115                 120                 125             
Cys Asp Ser Ser Gly Met Asn Leu Asn Asn Ile Ser Glu Leu Ile Ile
    130                 135                 140                 
Ser Asn Arg Ser Ser Phe Val Arg Asn Pro Ala Glu Cys Asn Val Arg
145                 150                 155                 160 
Gly Lys Phe Leu Leu Cys Met Lys Arg Glu Asn Pro Tyr Ala Arg Gly
                165                 170                 175     
Lys Pro Leu Glu Tyr Asp Gly Asn Gly Lys Ala Val Ser Gln Asn Glu
            180                 185                 190         
Asp Leu Phe Arg His Gln Tyr Ile Gln Thr Leu Lys Gln Cys Phe Glu
        195                 200                 205             
Tyr Asn Gln Cys Gly Lys Ala Phe His Glu Glu Ala Ala Cys Ser Thr
    210                 215                 220                 
His Lys Arg Arg Asn His Thr Ser Glu Lys Pro His Lys Cys Lys Glu
225                 230                 235                 240 
Cys Gly Ile Ala Phe Met Asn Ser Ser Ser Leu Leu Asn His His Lys
                245                 250                 255     
Val His Ala Gly Lys Gln Pro Tyr Arg Cys Ile Glu Cys Gly Lys Phe
            260                 265                 270         
Leu Lys Lys His Ser Thr Phe Ile Asn His Gln Arg Ile His Ser Arg
        275                 280                 285             
Glu Lys Pro His Lys Cys Ile Glu Cys Gly Lys Thr Phe Arg Lys Asn
    290                 295                 300                 
Ser Ile Leu Leu Ser His Gln Arg Ile His Thr Gly Gln Lys Pro Tyr
305                 310                 315                 320 
Lys Cys Asn Asp Cys Gly Lys Ala Phe Ala Gln Asn Ala Ala Leu Thr
                325                 330                 335     
Arg His Glu Arg Ile His Ser Gly Glu Lys Pro Phe Lys Cys Asn Lys
            340                 345                 350         
Cys Gly Arg Ala Phe Arg Asp Asn Ser Thr Val Leu Glu His Gln Lys
        355                 360                 365             
Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Asn Glu Cys Gly Lys Ala
    370                 375                 380                 
Phe Arg Lys Ser Ser Thr Leu Ile Ser His Gln Arg Met His Thr Gly
385                 390                 395                 400 
Glu Lys Pro Tyr His Cys Ser Lys Cys Gly Lys Ser Phe Arg Tyr Ser
                405                 410                 415     
Ser Ser Phe Ala Gly His Gln Lys Thr His Ser Gly Asn Lys Pro Tyr
            420                 425                 430         
Gln Cys Arg Asp Cys Gly Lys Ala Phe Thr Lys Ser Ser Thr Leu Thr
        435                 440                 445             
Gly His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr His Cys Lys Lys
    450                 455                 460                 
Cys Gly Lys Ala Phe Arg His Ser Ser Gly Leu Val Glu His Gln Arg
465                 470                 475                 480 
Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala
                485                 490                 495     
Phe Pro Arg Ser Ser Ala Leu Lys Gln His Lys Lys Ile His Asn Lys
            500                 505                 510         
Glu Arg Ala Met Lys Cys
        515             


<210> 7191
<211> 243
<212> PRT
<213> Homo sapiens

<400> 7191
Met Gln Glu Ile Ile Ala Ser Val Asp His Ile Lys Phe Asp Leu Glu
 1               5                  10                  15      
Ile Ala Val Glu Gln Gln Leu Gly Ala Gln Pro Leu Pro Phe Pro Gly
            20                  25                  30          
Met Asp Lys Ser Gly Ala Ala Val Cys Glu Phe Phe Leu Lys Ala Ala
        35                  40                  45              
Cys Gly Lys Gly Gly Met Cys Pro Phe Arg His Ile Ser Gly Glu Lys
    50                  55                  60                  
Thr Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp
65                  70                  75                  80  
Gln Cys Glu Phe Leu His Glu Tyr Asp Met Thr Lys Met Pro Glu Cys
                85                  90                  95      
Tyr Phe Tyr Ser Lys Phe Gly Glu Cys Ser Asn Lys Glu Cys Pro Phe
            100                 105                 110         
Leu His Ile Asp Pro Glu Ser Lys Ile Lys Asp Cys Pro Trp Tyr Asp
        115                 120                 125             
Arg Gly Phe Cys Lys His Gly Pro Leu Cys Arg His Arg His Thr Arg
    130                 135                 140                 
Arg Val Ile Cys Val Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Pro
145                 150                 155                 160 
Ser Cys Lys Phe Met His Pro Arg Phe Glu Leu Pro Met Gly Thr Thr
                165                 170                 175     
Glu Gln Pro Pro Leu Pro Gln Gln Thr Gln Pro Pro Ala Lys Arg Thr
            180                 185                 190         
Pro Gln Val Ile Gly Val Met Gln Ser Gln Asn Ser Ser Ala Gly Asn
        195                 200                 205             
Arg Gly Pro Arg Pro Leu Glu Gln Val Thr Cys Tyr Lys Cys Gly Glu
    210                 215                 220                 
Lys Gly His Tyr Ala Asn Arg Cys Thr Lys Gly His Leu Ala Phe Leu
225                 230                 235                 240 
Ser Gly Gln
            


<210> 7192
<211> 269
<212> PRT
<213> Homo sapiens

<400> 7192
Met Gln Glu Ile Ile Ala Ser Val Asp His Ile Lys Phe Asp Leu Glu
 1               5                  10                  15      
Ile Ala Val Glu Gln Gln Leu Gly Ala Gln Pro Leu Pro Phe Pro Gly
            20                  25                  30          
Met Asp Lys Ser Gly Ala Ala Val Cys Glu Phe Phe Leu Lys Ala Ala
        35                  40                  45              
Cys Gly Lys Gly Gly Met Cys Pro Phe Arg His Ile Ser Gly Glu Lys
    50                  55                  60                  
Thr Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp
65                  70                  75                  80  
Gln Cys Glu Phe Leu His Glu Tyr Asp Met Thr Lys Met Pro Glu Cys
                85                  90                  95      
Tyr Phe Tyr Ser Lys Phe Gly Glu Cys Ser Asn Lys Glu Cys Pro Phe
            100                 105                 110         
Leu His Ile Asp Pro Glu Ser Lys Ile Lys Asp Cys Pro Trp Tyr Asp
        115                 120                 125             
Arg Gly Phe Cys Lys His Gly Pro Leu Cys Arg His Arg His Thr Arg
    130                 135                 140                 
Arg Val Ile Cys Val Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Pro
145                 150                 155                 160 
Ser Cys Lys Phe Met His Pro Arg Phe Glu Leu Pro Met Gly Thr Thr
                165                 170                 175     
Glu Gln Pro Pro Leu Pro Gln Gln Thr Gln Pro Pro Ala Lys Gln Ser
            180                 185                 190         
Asn Asn Pro Pro Leu Gln Arg Ser Ser Ser Leu Ile Gln Leu Thr Ser
        195                 200                 205             
Gln Asn Ser Ser Pro Asn Gln Gln Arg Thr Pro Gln Val Ile Gly Val
    210                 215                 220                 
Met Gln Ser Gln Asn Ser Ser Ala Gly Asn Arg Gly Pro Arg Pro Leu
225                 230                 235                 240 
Glu Gln Val Thr Cys Tyr Lys Cys Gly Glu Lys Gly His Tyr Ala Asn
                245                 250                 255     
Arg Cys Thr Lys Gly His Leu Ala Phe Leu Ser Gly Gln
            260                 265                 


<210> 7193
<211> 244
<212> PRT
<213> Homo sapiens

<400> 7193
Met Gln Glu Ile Ile Ala Ser Val Asp His Ile Lys Phe Asp Leu Glu
 1               5                  10                  15      
Ile Ala Val Glu Gln Gln Leu Gly Ala Gln Pro Leu Pro Phe Pro Gly
            20                  25                  30          
Met Asp Lys Ser Gly Ala Ala Val Cys Glu Phe Phe Leu Lys Ala Ala
        35                  40                  45              
Cys Gly Lys Gly Gly Met Cys Pro Phe Arg His Ile Ser Gly Glu Lys
    50                  55                  60                  
Thr Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp
65                  70                  75                  80  
Gln Cys Glu Phe Leu His Glu Tyr Asp Met Thr Lys Met Pro Glu Cys
                85                  90                  95      
Tyr Phe Tyr Ser Lys Phe Gly Glu Cys Ser Asn Lys Glu Cys Pro Phe
            100                 105                 110         
Leu His Ile Asp Pro Glu Ser Lys Ile Lys Asp Cys Pro Trp Tyr Asp
        115                 120                 125             
Arg Gly Phe Cys Lys His Gly Pro Leu Cys Arg His Arg His Thr Arg
    130                 135                 140                 
Arg Val Ile Cys Val Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Pro
145                 150                 155                 160 
Ser Cys Lys Phe Met His Pro Arg Phe Glu Leu Pro Met Gly Thr Thr
                165                 170                 175     
Glu Gln Pro Pro Leu Pro Gln Gln Thr Gln Pro Pro Ala Lys Gln Arg
            180                 185                 190         
Thr Pro Gln Val Ile Gly Val Met Gln Ser Gln Asn Ser Ser Ala Gly
        195                 200                 205             
Asn Arg Gly Pro Arg Pro Leu Glu Gln Val Thr Cys Tyr Lys Cys Gly
    210                 215                 220                 
Glu Lys Gly His Tyr Ala Asn Arg Cys Thr Lys Gly His Leu Ala Phe
225                 230                 235                 240 
Leu Ser Gly Gln
                


<210> 7194
<211> 689
<212> PRT
<213> Homo sapiens

<400> 7194
Pro Gln Pro Gly Ser Thr Val Pro Arg Ser Pro Arg Leu Pro Pro Gly
 1               5                  10                  15      
Ser Cys Pro Arg Pro Arg Arg Leu Pro Gly Leu Gly Val Pro Gly Gln
            20                  25                  30          
Pro Pro Arg Arg Gly Pro Pro Ala Val Ala Met Ala Cys Ser Leu Gln
        35                  40                  45              
Lys Leu Phe Ala Val Glu Glu Glu Phe Glu Asp Glu Asp Phe Leu Ser
    50                  55                  60                  
Ala Val Glu Asp Ala Glu Asn Arg Phe Thr Gly Ser Leu Pro Val Asn
65                  70                  75                  80  
Ala Gly Arg Leu Arg Pro Val Ser Ser Arg Pro Gln Glu Thr Val Gln
                85                  90                  95      
Ala Gln Ser Ser Arg Leu Leu Leu Leu His Pro Thr Ala Pro Ser Glu
            100                 105                 110         
Ala Leu Gly Leu Pro Asp Leu Asp Leu Cys Leu Pro Ala Ser Ser Thr
        115                 120                 125             
Pro Ser Ala Asp Ser Arg Pro Ser Cys Ile Gly Ala Ala Pro Leu Arg
    130                 135                 140                 
Pro Val Ser Thr Ser Ser Ser Trp Ile Gly Asn Gln Arg Arg Val Thr
145                 150                 155                 160 
Val Thr Glu Val Leu Arg Glu Thr Ala Arg Pro Gln Ser Ser Ala Leu
                165                 170                 175     
His Pro Leu Leu Thr Phe Glu Ser Gln Gln Gln Gln Val Gly Gly Phe
            180                 185                 190         
Glu Gly Pro Glu Gln Asp Glu Phe Asp Lys Val Leu Ala Ser Met Glu
        195                 200                 205             
Leu Glu Glu Pro Gly Met Glu Leu Glu Cys Gly Val Ser Ser Glu Ala
    210                 215                 220                 
Ile Pro Ile Leu Pro Ala Gln Gln Arg Glu Gly Ser Val Leu Ala Lys
225                 230                 235                 240 
Lys Ala Arg Val Val Asp Leu Ser Gly Ser Cys Gln Lys Gly Pro Val
                245                 250                 255     
Pro Ala Ile His Lys Ala Gly Ile Met Ser Ala Gln Asp Glu Ser Leu
            260                 265                 270         
Asp Pro Val Ile Gln Cys Arg Thr Pro Arg Pro Pro Leu Arg Pro Gly
        275                 280                 285             
Ala Val Gly His Leu Pro Val Pro Thr Ala Leu Thr Val Pro Thr Gln
    290                 295                 300                 
Gln Leu His Trp Glu Val Cys Pro Gln Arg Ser Pro Val Gln Ala Leu
305                 310                 315                 320 
Gln Pro Leu Gln Ala Ala Arg Gly Thr Ile Gln Ser Ser Pro Gln Asn
                325                 330                 335     
Arg Phe Pro Cys Gln Pro Phe Gln Ser Pro Ser Ser Trp Leu Ser Gly
            340                 345                 350         
Lys Ala His Leu Pro Arg Pro Arg Thr Pro Asn Ser Ser Cys Ser Thr
        355                 360                 365             
Pro Ser Arg Thr Ser Ser Gly Leu Phe Pro Arg Ile Pro Leu Gln Pro
    370                 375                 380                 
Gln Ala Pro Val Ser Ser Ile Gly Ser Pro Val Gly Thr Pro Lys Gly
385                 390                 395                 400 
Pro Gln Gly Ala Leu Gln Thr Pro Ile Val Thr Asn His Leu Val Gln
                405                 410                 415     
Leu Val Thr Ala Ala Ser Arg Thr Pro Gln Gln Pro Thr His Pro Ser
            420                 425                 430         
Thr Arg Ala Lys Thr Arg Arg Phe Pro Gly Pro Ala Gly Ile Leu Pro
        435                 440                 445             
His Gln Gln Ser Gly Arg Ser Leu Glu Asp Ile Met Val Ser Ala Pro
    450                 455                 460                 
Gln Thr Pro Thr His Gly Ala Leu Ala Lys Phe Gln Thr Glu Ile Val
465                 470                 475                 480 
Ala Ser Ser Gln Ala Ser Val Glu Glu Asp Phe Gly Arg Gly Pro Trp
                485                 490                 495     
Leu Thr Met Lys Ser Thr Leu Gly Leu Asp Glu Arg Asp Pro Ser Cys
            500                 505                 510         
Phe Leu Cys Thr Tyr Ser Ile Val Met Val Leu Arg Lys Gln Ala Ala
        515                 520                 525             
Leu Lys Gln Leu Pro Arg Asn Lys Val Pro Asn Met Ala Val Met Ile
    530                 535                 540                 
Lys Ser Leu Thr Arg Ser Thr Met Asp Ala Ser Val Val Phe Lys Asp
545                 550                 555                 560 
Pro Thr Gly Glu Met Gln Gly Thr Val His Arg Leu Leu Leu Glu Thr
                565                 570                 575     
Cys Gln Asn Glu Leu Lys Pro Gly Ser Val Leu Leu Leu Lys Gln Ile
            580                 585                 590         
Gly Val Phe Ser Pro Ser Leu Arg Asn His Tyr Leu Asn Val Thr Pro
        595                 600                 605             
Asn Asn Leu Val His Ile Tyr Ser Pro Asp Ser Gly Asp Gly Ser Phe
    610                 615                 620                 
Leu Lys Pro Ser Gln Pro Phe Pro Lys Asp Ser Gly Ser Phe Gln His
625                 630                 635                 640 
Asp Val Ala Ala Lys Pro Glu Glu Gly Phe Arg Thr Ala Gln Asn Leu
                645                 650                 655     
Glu Ala Glu Ala Ser Pro Glu Glu Glu Leu Pro Glu Ala Asp Asp Leu
            660                 665                 670         
Asp Gly Leu Leu Ser Glu Leu Pro Glu Asp Phe Phe Cys Gly Thr Ser
        675                 680                 685             
Ser
    


<210> 7195
<211> 563
<212> PRT
<213> Homo sapiens

<400> 7195
Pro Gln Pro Gly Ser Thr Val Pro Arg Ser Pro Arg Leu Pro Pro Gly
 1               5                  10                  15      
Ser Cys Pro Arg Pro Arg Arg Leu Pro Gly Leu Gly Val Pro Gly Gln
            20                  25                  30          
Pro Pro Arg Arg Gly Pro Pro Ala Val Ala Met Ala Cys Ser Leu Gln
        35                  40                  45              
Lys Leu Phe Ala Val Glu Glu Glu Phe Glu Asp Glu Asp Phe Leu Ser
    50                  55                  60                  
Ala Val Glu Asp Ala Glu Asn Arg Phe Thr Gly Ser Leu Pro Val Asn
65                  70                  75                  80  
Ala Gly Arg Leu Arg Pro Val Ser Ser Arg Pro Gln Glu Thr Val Gln
                85                  90                  95      
Ala Gln Ser Ser Arg Leu Leu Leu Leu His Pro Thr Ala Pro Ser Glu
            100                 105                 110         
Ala Leu Gly Leu Pro Asp Leu Asp Leu Cys Leu Pro Ala Ser Ser Thr
        115                 120                 125             
Pro Ser Ala Asp Ser Arg Pro Ser Cys Ile Gly Ala Ala Pro Leu Arg
    130                 135                 140                 
Pro Val Ser Thr Ser Ser Ser Trp Ile Gly Asn Gln Arg Arg Val Thr
145                 150                 155                 160 
Val Thr Glu Val Leu Arg Glu Thr Ala Arg Pro Gln Ser Ser Ala Leu
                165                 170                 175     
His Pro Leu Leu Thr Phe Glu Ser Gln Gln Gln Gln Val Gly Gly Phe
            180                 185                 190         
Glu Gly Pro Glu Gln Asp Glu Phe Asp Lys Val Leu Ala Ser Met Glu
        195                 200                 205             
Leu Glu Glu Pro Gly Met Glu Leu Glu Cys Gly Val Ser Ser Glu Ala
    210                 215                 220                 
Ile Pro Ile Leu Pro Ala Gln Gln Arg Glu Gly Ser Val Leu Ala Lys
225                 230                 235                 240 
Lys Ala Arg Val Val Asp Leu Ser Gly Ser Cys Gln Lys Gly Pro Val
                245                 250                 255     
Pro Ala Ile His Lys Ala Gly Ile Met Ser Ala Gln Asp Glu Ser Leu
            260                 265                 270         
Asp Pro Val Ile Gln Cys Arg Thr Pro Arg Pro Pro Leu Arg Pro Gly
        275                 280                 285             
Ala Val Gly His Leu Pro Val Pro Thr Ala Leu Thr Val Pro Thr Gln
    290                 295                 300                 
Gln Leu His Trp Glu Val Cys Pro Gln Arg Ser Pro Val Gln Ala Leu
305                 310                 315                 320 
Gln Pro Leu Gln Ala Ala Arg Gly Thr Ile Gln Ser Ser Pro Gln Asn
                325                 330                 335     
Arg Phe Pro Cys Gln Pro Phe Gln Ser Pro Ser Ser Trp Leu Ser Gly
            340                 345                 350         
Lys Ala His Leu Pro Arg Pro Arg Thr Pro Asn Ser Ser Cys Ser Thr
        355                 360                 365             
Pro Ser Arg Thr Ser Ser Gly Leu Phe Pro Arg Ile Pro Leu Gln Pro
    370                 375                 380                 
Gln Ala Pro Val Ser Ser Ile Gly Ser Pro Val Gly Thr Pro Lys Gly
385                 390                 395                 400 
Pro Gln Gly Ala Leu Gln Thr Pro Ile Val Thr Asn His Leu Val Gln
                405                 410                 415     
Leu Val Thr Ala Ala Ser Arg Thr Pro Gln Gln Pro Thr His Pro Ser
            420                 425                 430         
Thr Arg Ala Lys Thr Arg Arg Phe Pro Gly Pro Ala Gly Ile Leu Pro
        435                 440                 445             
His Gln Ala Ala Leu Lys Gln Leu Pro Arg Asn Lys Val Pro Asn Met
    450                 455                 460                 
Ala Val Met Ile Lys Ser Leu Thr Arg Ser Thr Met Asp Ala Ser Val
465                 470                 475                 480 
Val Phe Lys Asp Pro Thr Gly Glu Met Gln Gly Thr Val His Arg Leu
                485                 490                 495     
Leu Leu Glu Thr Cys Gln Asn Glu Leu Lys Pro Gly Ser Val Leu Leu
            500                 505                 510         
Leu Lys Gln Ile Gly Val Phe Ser Pro Ser Leu Arg Asn His Tyr Leu
        515                 520                 525             
Asn Val Thr Pro Asn Asn Leu Val His Ile Tyr Ser Pro Asp Ser Gly
    530                 535                 540                 
Asp Gly Ser Phe Leu Lys Pro Ser Gln Pro Phe Pro Lys Met Thr Trp
545                 550                 555                 560 
Met Asp Ser
            


<210> 7196
<211> 1057
<212> PRT
<213> Homo sapiens

<400> 7196
Met Met Gly Asp Tyr Arg Leu Pro Asp His Pro Gln Pro Met Glu Ile
 1               5                  10                  15      
Leu Asn Leu Tyr Leu Gly Asp Ser Leu Glu Pro His Pro Gly Glu Cys
            20                  25                  30          
Pro Arg Glu Thr Cys Ser His Glu Asp Pro Pro Glu Pro Phe Glu Glu
        35                  40                  45              
Gln Thr Trp Ala Thr Asp Pro Pro Glu Pro Thr Arg Gln Asn Val Pro
    50                  55                  60                  
Pro Trp Gly Ser Gly Val Glu Leu Thr His Leu Gly Ser Trp Val His
65                  70                  75                  80  
Gln Asp Gly Leu Glu Pro Cys Gln Glu Gln Thr Arg Ala Thr Asp Pro
                85                  90                  95      
Pro Glu Ser Thr Arg Gln Asp Ala Pro Pro Trp Gly Ser Gly Val Glu
            100                 105                 110         
Leu Thr His Leu Gly Ser Pro Ser Ala Gln Arg Glu His Arg Gln Asn
        115                 120                 125             
Thr Ala Ser Pro Gly Ser Pro Val Asn Ser His Leu Pro Gly Ser Pro
    130                 135                 140                 
Lys Gln Asn Arg Ser Thr Ser Thr Gln Val Val Phe Trp Ala Gly Ile
145                 150                 155                 160 
Leu Gln Ala Gln Met Cys Val Leu Asp Leu Glu Glu Glu Leu Glu Lys
                165                 170                 175     
Thr Glu Gly Leu Lys Ala Gly Leu Lys Cys Cys Leu Pro Thr Pro Pro
            180                 185                 190         
Val Asp Leu Pro Gly Asp Thr Gly Leu His Ser Ser Pro Pro Glu Asn
        195                 200                 205             
Glu Asp Ser Gly Glu Asp Ser Ser Glu Pro Glu Gly Glu Gly Gln Ala
    210                 215                 220                 
Trp Leu Arg Glu Gly Thr Pro Asp Ser Ser Pro Gln Trp Gly Ala Glu
225                 230                 235                 240 
Glu Glu Ser Met Phe Phe Ser Asn Pro Leu Phe Leu Ala Ser Pro Cys
                245                 250                 255     
Ser Glu Asn Ser Ala Ser Gly Glu Cys Phe Ser Trp Gly Ala Ser Asp
            260                 265                 270         
Ser His Ala Gly Val Arg Thr Gly Pro Glu Ser Pro Ala Thr Leu Glu
        275                 280                 285             
Pro Pro Leu Pro Glu Asp Thr Val Leu Trp Glu Leu Glu Ser Glu Pro
    290                 295                 300                 
Asp Leu Gly Asp Gly Ala Ala Ile Ser Gly His Cys Thr Pro Pro Phe
305                 310                 315                 320 
Pro Val Pro Ile Tyr Lys Pro His Ser Ile Cys Trp Ala Ser Val Ala
                325                 330                 335     
Ala Ala Glu Gly Ala Pro Ala Ala Pro Pro Gly His Gly Glu Ser Glu
            340                 345                 350         
Gly Asp Arg Leu Gly Pro Ala Pro Ser Ala Ala Pro Cys Val Asp Glu
        355                 360                 365             
Ala Leu Thr Trp Glu Ser Gly Cys Val Gly Ser Asp Leu Gly Pro Ala
    370                 375                 380                 
Ala His Pro Val Gln Pro Trp Ala Ser Ser Leu Ser Pro Glu Gly Trp
385                 390                 395                 400 
Gln Arg Gly Gly Pro Phe Trp Pro Gln Val Thr Leu Asn Ser Gln Asp
                405                 410                 415     
Arg Asp Glu Arg Glu Gly Gly His Pro Gln Glu Ser Leu Pro Cys Thr
            420                 425                 430         
Leu Ala Pro Cys Pro Trp Arg Ser Pro Ala Ser Ser Pro Glu Pro Ser
        435                 440                 445             
Ser Pro Glu Ser Glu Ser Arg Gly Pro Gly Pro Arg Pro Ser Pro Ala
    450                 455                 460                 
Ser Ser Gln Glu Gly Ser Pro Gln Leu Gln His His Ser Ser Gly Ile
465                 470                 475                 480 
Leu Pro Lys Trp Thr Leu Asp Ala Ser Gln Ser Ser Leu Leu Glu Thr
                485                 490                 495     
Asp Gly Glu Gln Pro Ser Ser Leu Lys Lys Lys Glu Ala Gly Glu Ala
            500                 505                 510         
Pro Lys Pro Gly Glu Glu Val Lys Ser Glu Gly Thr Ala Arg Pro Ala
        515                 520                 525             
Glu Thr Gly Asp Val Gln Pro Asp Ile His Leu Thr Ser Ala Glu His
    530                 535                 540                 
Glu Asn Leu Arg Thr Pro Met Asn Ser Ser Trp Leu Pro Gly Ser Pro
545                 550                 555                 560 
Met Pro Gln Ala Gln Ser Pro Glu Glu Gly Gln Arg Pro Pro Ala Gly
                565                 570                 575     
Asp Lys Leu Ala Asn Gly Val Arg Asn Asn Lys Val Ala Trp Asn Leu
            580                 585                 590         
Ala Ser Arg Leu Tyr Arg Leu Glu Gly Phe Arg Lys Ser Glu Val Ala
        595                 600                 605             
Ala Tyr Leu Gln Lys Asn Asn Asp Phe Ser Arg Ala Val Ala Glu Glu
    610                 615                 620                 
Tyr Leu Ser Phe Phe Gln Phe Gly Gly Gln Ser Leu Asp Arg Ala Leu
625                 630                 635                 640 
Arg Ser Phe Leu Gln Ala Leu Val Leu Ser Gly Glu Thr Gln Glu Arg
                645                 650                 655     
Glu Arg Ile Leu Tyr Gln Phe Ser Arg Arg Phe His His Cys Asn Pro
            660                 665                 670         
Gly Ile Phe Pro Ser Val Asp Ser Val His Thr Leu Thr Cys Ala Ile
        675                 680                 685             
Met Leu Leu Asn Thr Asp Leu His Gly Gln Asn Ile Gly Lys Ser Met
    690                 695                 700                 
Ser Cys Gln Glu Phe Ile Thr Asn Leu Asn Gly Leu Arg Asp Gly Gly
705                 710                 715                 720 
Asn Phe Pro Lys Glu Leu Leu Lys Ala Leu Tyr Trp Ser Ile Arg Ser
                725                 730                 735     
Glu Lys Leu Glu Trp Ala Val Asp Glu Glu Asp Thr Ala Arg Pro Glu
            740                 745                 750         
Lys Ala Gln Pro Ser Leu Pro Ala Gly Lys Met Ser Lys Pro Phe Leu
        755                 760                 765             
Gln Leu Ala Gln Asp Pro Thr Val Pro Thr Tyr Lys Gln Gly Ile Leu
    770                 775                 780                 
Ala Arg Lys Met His Gln Asp Ala Asp Gly Lys Lys Thr Pro Trp Gly
785                 790                 795                 800 
Lys Arg Gly Trp Lys Met Phe His Thr Leu Leu Arg Gly Met Val Leu
                805                 810                 815     
Tyr Phe Leu Lys Gln Gly Glu Asp His Cys Leu Glu Gly Glu Ser Leu
            820                 825                 830         
Val Gly Gln Met Val Asp Glu Pro Val Gly Val His His Ser Leu Ala
        835                 840                 845             
Thr Pro Ala Thr His Tyr Thr Lys Lys Pro His Val Phe Gln Leu Arg
    850                 855                 860                 
Thr Ala Asp Trp Arg Leu Tyr Leu Phe Gln Ala Pro Thr Ala Lys Glu
865                 870                 875                 880 
Met Ser Ser Trp Ile Ala Arg Ile Asn Leu Ala Ala Ala Thr His Ser
                885                 890                 895     
Ala Pro Pro Phe Pro Ala Ala Val Gly Ser Gln Arg Arg Phe Val Arg
            900                 905                 910         
Pro Ile Leu Pro Val Gly Pro Ala Gln Ser Ser Leu Glu Glu Gln His
        915                 920                 925             
Arg Ser His Glu Asn Cys Leu Asp Ala Ala Ala Asp Asp Leu Leu Asp
    930                 935                 940                 
Leu Gln Arg Asn Leu Pro Glu Arg Arg Gly Arg Gly Arg Glu Leu Glu
945                 950                 955                 960 
Glu His Arg Leu Arg Lys Glu Tyr Leu Glu Tyr Glu Lys Thr Arg Tyr
                965                 970                 975     
Glu Thr Tyr Val Gln Leu Leu Val Ala Arg Leu His Cys Pro Ser Asp
            980                 985                 990         
Ala Leu Asp Leu Trp Glu Glu Gln Leu Gly Arg Glu Ala Gly Gly Thr
        995                 1000                1005            
Arg Glu Pro Lys Leu Ser Leu Lys Lys Ser His Ser Ser Pro Ser Leu
    1010                1015                1020                
His Gln Asp Glu Ala Pro Thr Thr Ala Lys Val Lys Arg Asn Ile Ser
1025                1030                1035                1040
Glu Arg Arg Thr Tyr Arg Lys Ile Ile Pro Lys Arg Asn Arg Asn Gln
                1045                1050                1055    
Leu
    


<210> 7197
<211> 1426
<212> PRT
<213> Homo sapiens

<400> 7197
Met His Ser Ser Asn Pro Lys Val Arg Ser Ser Pro Ser Gly Asn Thr
 1               5                  10                  15      
Gln Ser Ser Pro Lys Ser Lys Gln Glu Val Met Val Arg Pro Pro Thr
            20                  25                  30          
Val Met Ser Pro Ser Gly Asn Pro Gln Leu Asp Ser Lys Phe Ser Asn
        35                  40                  45              
Gln Gly Lys Gln Gly Gly Ser Ala Ser Gln Ser Gln Pro Ser Pro Cys
    50                  55                  60                  
Asp Ser Lys Ser Gly Gly His Thr Pro Lys Ala Leu Pro Gly Pro Gly
65                  70                  75                  80  
Gly Ser Met Gly Leu Lys Asn Gly Ala Gly Asn Gly Ala Lys Gly Lys
                85                  90                  95      
Gly Lys Arg Glu Arg Ser Ile Ser Ala Asp Ser Phe Asp Gln Arg Asp
            100                 105                 110         
Pro Gly Thr Pro Asn Asp Asp Ser Asp Ile Lys Glu Cys Asn Ser Ala
        115                 120                 125             
Asp His Ile Lys Ser Gln Asp Ser Gln His Thr Pro His Ser Met Thr
    130                 135                 140                 
Pro Ser Asn Ala Thr Ala Pro Arg Ser Ser Thr Pro Ser His Gly Gln
145                 150                 155                 160 
Thr Thr Ala Thr Glu Pro Thr Pro Ala Gln Lys Thr Pro Ala Lys Val
                165                 170                 175     
Val Tyr Val Phe Ser Thr Glu Met Ala Asn Lys Ala Ala Glu Ala Val
            180                 185                 190         
Leu Lys Gly Gln Val Glu Thr Ile Val Ser Phe His Ile Gln Asn Ile
        195                 200                 205             
Ser Asn Asn Lys Thr Glu Arg Ser Thr Ala Pro Leu Asn Thr Gln Ile
    210                 215                 220                 
Ser Ala Leu Arg Asn Asp Pro Lys Pro Leu Pro Gln Gln Pro Pro Val
225                 230                 235                 240 
Pro Ala Asn Gln Asp Gln Asn Ser Ser Gln Asn Thr Arg Leu Gln Pro
                245                 250                 255     
Thr Pro Pro Ile Pro Ala Pro Ala Pro Lys Pro Ala Ala Pro Pro Arg
            260                 265                 270         
Pro Leu Asp Arg Glu Ser Pro Gly Val Glu Asn Lys Leu Ile Pro Ser
        275                 280                 285             
Val Gly Ser Pro Ala Ser Ser Thr Pro Leu Pro Pro Asp Gly Thr Gly
    290                 295                 300                 
Pro Asn Ser Thr Pro Asn Asn Arg Ala Val Thr Pro Val Ser Gln Gly
305                 310                 315                 320 
Ser Asn Ser Ser Ser Ala Asp Pro Lys Ala Pro Pro Pro Pro Pro Val
                325                 330                 335     
Ser Ser Gly Glu Pro Pro Thr Leu Gly Glu Asn Pro Asp Gly Leu Ser
            340                 345                 350         
Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu Arg Asp
        355                 360                 365             
Ile Gln Arg Met Leu Phe Pro Asp Glu Lys Glu Phe Thr Gly Ala Gln
    370                 375                 380                 
Ser Gly Gly Pro Gln Gln Asn Pro Gly Val Leu Asp Gly Pro Gln Lys
385                 390                 395                 400 
Lys Pro Glu Gly Pro Ile Gln Ala Met Met Ala Gln Ser Gln Ser Leu
                405                 410                 415     
Gly Lys Gly Pro Gly Pro Arg Thr Asp Val Gly Ala Pro Phe Gly Pro
            420                 425                 430         
Gln Gly His Arg Asp Val Pro Phe Ser Pro Asp Glu Met Val Pro Pro
        435                 440                 445             
Ser Met Asn Ser Gln Ser Gly Thr Ile Gly Pro Asp His Leu Asp His
    450                 455                 460                 
Met Thr Pro Glu Gln Ile Ala Trp Leu Lys Leu Gln Gln Glu Phe Tyr
465                 470                 475                 480 
Glu Glu Lys Arg Arg Lys Pro Glu Gln Val Val Val Gln Gln Cys Ser
                485                 490                 495     
Leu Gln Asp Met Met Val His Gln His Gly Pro Arg Gly Val Val Arg
            500                 505                 510         
Gly Pro Pro Pro Pro Tyr Gln Met Thr Pro Ser Glu Gly Trp Ala Pro
        515                 520                 525             
Gly Gly Thr Glu Pro Phe Ser Asp Gly Ile Asn Met Pro His Ser Leu
    530                 535                 540                 
Pro Pro Arg Gly Met Ala Pro His Pro Asn Met Pro Gly Ser Gln Met
545                 550                 555                 560 
Arg Leu Pro Gly Phe Ala Gly Met Ile Asn Ser Glu Met Glu Gly Pro
                565                 570                 575     
Asn Val Pro Asn Pro Ala Ser Arg Pro Gly Leu Ser Gly Val Ser Trp
            580                 585                 590         
Pro Asp Asp Val Pro Lys Ile Pro Asp Gly Arg Asn Phe Pro Pro Gly
        595                 600                 605             
Arg Gly Ile Phe Ser Gly Pro Gly Arg Gly Glu Arg Phe Pro Asn Pro
    610                 615                 620                 
Gln Gly Leu Ser Glu Glu Met Phe Gln Gln Gln Leu Ala Glu Lys Gln
625                 630                 635                 640 
Leu Gly Leu Pro Pro Gly Met Ala Met Glu Gly Ile Arg Pro Ser Met
                645                 650                 655     
Glu Met Asn Arg Met Ile Pro Gly Ser Gln Arg His Met Glu Pro Gly
            660                 665                 670         
Asn Asn Pro Ile Phe Pro Arg Ile Pro Val Glu Gly Pro Leu Ser Pro
        675                 680                 685             
Ser Arg Gly Asp Phe Pro Lys Gly Ile Pro Pro Gln Met Gly Pro Gly
    690                 695                 700                 
Arg Glu Leu Glu Phe Gly Met Val Pro Ser Gly Met Lys Gly Asp Val
705                 710                 715                 720 
Asn Leu Asn Val Asn Met Gly Ser Asn Ser Gln Met Ile Pro Gln Lys
                725                 730                 735     
Met Arg Glu Ala Gly Ala Gly Pro Glu Glu Met Leu Lys Leu Arg Pro
            740                 745                 750         
Gly Gly Ser Asp Met Leu Pro Ala Gln Gln Lys Met Val Pro Leu Pro
        755                 760                 765             
Phe Gly Glu His Pro Gln Gln Glu Tyr Gly Met Gly Pro Arg Pro Phe
    770                 775                 780                 
Leu Pro Met Ser Gln Gly Pro Gly Ser Asn Ser Gly Leu Arg Asn Leu
785                 790                 795                 800 
Arg Glu Pro Ile Gly Pro Asp Gln Arg Thr Asn Ser Arg Leu Ser His
                805                 810                 815     
Met Pro Pro Leu Pro Leu Asn Pro Ser Ser Asn Pro Thr Ser Leu Asn
            820                 825                 830         
Thr Ala Pro Pro Val Gln Arg Gly Leu Gly Arg Lys Pro Leu Asp Ile
        835                 840                 845             
Ser Val Ala Gly Ser Gln Val His Ser Pro Gly Ile Asn Pro Leu Lys
    850                 855                 860                 
Ser Pro Thr Met His Gln Val Gln Ser Pro Met Leu Gly Ser Pro Ser
865                 870                 875                 880 
Gly Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln Leu Ala Gly Met Leu
                885                 890                 895     
Ala Gly Pro Ala Ala Ala Ala Ser Ile Lys Ser Pro Pro Val Leu Gly
            900                 905                 910         
Ser Ala Ala Ala Ser Pro Val His Leu Lys Ser Pro Ser Leu Pro Ala
        915                 920                 925             
Pro Ser Pro Gly Trp Thr Ser Ser Pro Lys Pro Pro Leu Gln Ser Pro
    930                 935                 940                 
Gly Ile Pro Pro Asn His Lys Ala Pro Leu Thr Met Ala Ser Pro Ala
945                 950                 955                 960 
Met Leu Gly Asn Val Glu Ser Gly Gly Pro Pro Pro Pro Thr Ala Ser
                965                 970                 975     
Gln Pro Ala Ser Val Asn Ile Pro Gly Ser Leu Pro Ser Ser Thr Pro
            980                 985                 990         
Tyr Thr Met Pro Pro Glu Pro Thr Leu Ser Gln Asn Pro Leu Ser Ile
        995                 1000                1005            
Met Met Ser Arg Met Ser Lys Phe Ala Met Pro Ser Ser Thr Pro Leu
    1010                1015                1020                
Tyr His Asp Ala Ile Lys Thr Val Ala Ser Ser Asp Asp Asp Ser Pro
1025                1030                1035                1040
Pro Ala Arg Ser Pro Asn Leu Pro Ser Met Asn Asn Met Pro Gly Met
                1045                1050                1055    
Gly Ile Asn Thr Gln Asn Pro Arg Ile Ser Gly Pro Asn Pro Val Val
            1060                1065                1070        
Pro Met Pro Thr Leu Ser Pro Met Gly Met Thr Gln Pro Leu Ser His
        1075                1080                1085            
Ser Asn Gln Met Pro Ser Pro Asn Ala Val Gly Pro Asn Ile Pro Pro
    1090                1095                1100                
His Gly Val Pro Met Gly Pro Gly Leu Met Ser His Asn Pro Ile Met
1105                1110                1115                1120
Gly His Gly Ser Gln Glu Pro Pro Met Val Pro Gln Gly Arg Met Gly
                1125                1130                1135    
Phe Pro Gln Gly Phe Pro Pro Val Gln Ser Pro Pro Gln Gln Val Pro
            1140                1145                1150        
Phe Pro His Asn Gly Pro Ser Gly Gly Gln Gly Ser Phe Pro Gly Gly
        1155                1160                1165            
Met Gly Phe Pro Gly Glu Gly Pro Leu Gly Arg Pro Ser Asn Leu Pro
    1170                1175                1180                
Gln Ser Ser Ala Asp Ala Ala Leu Cys Lys Pro Gly Gly Pro Gly Gly
1185                1190                1195                1200
Pro Asp Ser Phe Thr Val Leu Gly Asn Ser Met Pro Ser Val Phe Thr
                1205                1210                1215    
Asp Pro Asp Leu Gln Glu Val Ile Arg Pro Gly Ala Thr Gly Ile Pro
            1220                1225                1230        
Glu Phe Asp Leu Ser Arg Ile Ile Pro Ser Glu Lys Pro Ser Gln Thr
        1235                1240                1245            
Leu Gln Tyr Phe Pro Arg Gly Glu Val Pro Gly Arg Lys Gln Pro Gln
    1250                1255                1260                
Gly Pro Gly Pro Gly Phe Ser His Met Gln Gly Met Met Gly Glu Gln
1265                1270                1275                1280
Ala Pro Arg Met Gly Leu Ala Leu Pro Gly Met Gly Gly Pro Gly Pro
                1285                1290                1295    
Val Gly Thr Pro Asp Ile Pro Leu Gly Thr Ala Pro Ser Met Pro Gly
            1300                1305                1310        
His Asn Pro Met Arg Pro Pro Ala Phe Leu Gln Gln Gly Met Met Gly
        1315                1320                1325            
Pro His His Arg Met Met Ser Pro Ala Gln Ser Thr Met Pro Gly Gln
    1330                1335                1340                
Pro Thr Leu Met Ser Asn Pro Ala Ala Ala Val Gly Met Ile Pro Gly
1345                1350                1355                1360
Lys Asp Arg Gly Pro Ala Gly Leu Tyr Thr His Pro Gly Pro Val Gly
                1365                1370                1375    
Ser Pro Gly Met Met Met Ser Met Gln Gly Met Met Gly Pro Gln Gln
            1380                1385                1390        
Asn Ile Met Ile Pro Pro Gln Met Arg Pro Arg Gly Met Ala Ala Asp
        1395                1400                1405            
Val Gly Met Gly Gly Phe Ser Gln Gly Pro Gly Asn Pro Gly Asn Met
    1410                1415                1420                
Met Phe
1425    


<210> 7198
<211> 388
<212> PRT
<213> Homo sapiens

<400> 7198
Met Asp Val Lys Asp Arg Arg His Arg Ser Leu Thr Arg Gly Arg Cys
 1               5                  10                  15      
Gly Lys Glu Cys Arg Tyr Thr Ser Ser Ser Leu Asp Ser Glu Asp Cys
            20                  25                  30          
Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys Ala
        35                  40                  45              
Tyr Asp His Asp Ser Arg Met His Tyr Gly Asn Arg Val Thr Asp Leu
    50                  55                  60                  
Ile His Arg Glu Ser Asp Glu Phe Pro Arg Gln Val Phe Leu Phe Lys
65                  70                  75                  80  
Thr Gln Asp Thr Asp His Lys Thr Asn Thr Leu Leu Thr Tyr Asn Gln
                85                  90                  95      
Val Leu Gln Thr Gln Leu Asp Asp Ser Thr Asp Ala Gln Gly Gly Lys
            100                 105                 110         
Glu Leu Pro Ala Ser Lys Ser Asp Gly Gly Pro Glu Ser Asp Leu Val
        115                 120                 125             
Gln Leu Pro Gln Leu Ala His Ser Ser Ile Lys Cys Lys Asn Leu Pro
    130                 135                 140                 
Ser Pro Ser Arg Arg Asn Glu Pro Gly Lys Arg Phe Asp Cys Arg Asp
145                 150                 155                 160 
Val Tyr Trp Ala Val Ser Thr Asp Ser Met Pro Ser Leu Met Val Ile
                165                 170                 175     
Thr Phe Leu His Lys Leu Ser Thr Trp Asn Thr Asn Lys Glu Arg Cys
            180                 185                 190         
His Tyr Leu Asn Asp Ile Ala Gln Thr Leu Leu Val Cys Arg Met Glu
        195                 200                 205             
Ala Val Leu Leu Thr Pro Tyr Arg Phe Ala Phe Asp Glu Arg Pro Thr
    210                 215                 220                 
Leu Lys Met Val Ser Val Phe Phe Pro Ala Ala Thr Glu Leu Thr Glu
225                 230                 235                 240 
Asn Ile Ile Met Arg Asp Glu Leu Gly Gln Asn Gln Ser Pro Ile Asp
                245                 250                 255     
Glu Gln Arg Thr Asn Phe Thr Leu Ala Glu Leu Gly Ile Cys Glu Pro
            260                 265                 270         
Ser Pro His Arg Ser Gly Tyr Cys Ser Asp Met Gly Ile Leu His Gln
        275                 280                 285             
Gly Tyr Ser Leu Ser Thr Gly Ser Asp Ala Asp Ser Asp Thr Glu Gly
    290                 295                 300                 
Gly Met Ser Pro Glu His Ala Ile Arg Leu Trp Gly Arg Gly Ile Lys
305                 310                 315                 320 
Ser Arg Arg Ser Ser Gly Leu Ser Ser Arg Glu Asn Ser Ala Leu Thr
                325                 330                 335     
Leu Thr Asp Ser Asp Asn Glu Asn Lys Ser Asp Asp Glu Asn Glu Ser
            340                 345                 350         
Gly Leu Ser Ile Asn Leu Ala Leu Glu Arg Phe Leu Ser Lys His Lys
        355                 360                 365             
Leu Asn Met Arg Val Glu Phe Tyr Phe Tyr Ser His Ser Ile Thr Leu
    370                 375                 380                 
Thr Cys Ser Asn
385             


<210> 7199
<211> 534
<212> PRT
<213> Homo sapiens

<400> 7199
Met Lys Gln Pro Asn Arg Lys Arg Lys Leu Asn Met Asp Ser Lys Glu
 1               5                  10                  15      
Arg Leu Asp Gln Asp Gly Arg Leu Glu Gln Ala Glu Glu Glu Lys Lys
            20                  25                  30          
Pro Lys Asp Ser Thr Thr Pro Leu Ser His Val Pro Ser Ala Ala Ala
        35                  40                  45              
Gln Gly Ala Trp Ser Trp Glu Trp Tyr Leu Lys Glu Gln Lys Ala Val
    50                  55                  60                  
Ala Ala Pro Val Glu Leu Phe Ser Lys Asp Gln Ser Phe Pro Glu His
65                  70                  75                  80  
Glu Asn Gly Phe Gln Ile Gly Met Arg Leu Glu Gly Ile Asp Pro Arg
                85                  90                  95      
His Pro Ser Val Phe Cys Val Leu Ser Val Ala Glu Val Cys Gly Tyr
            100                 105                 110         
Arg Leu Arg Leu His Phe Asp Gly Tyr Leu Ser Cys Tyr Asp Phe Trp
        115                 120                 125             
Thr Asn Ala Gly Ser Pro Asp Ile His Pro Val Gly Trp Cys Glu Lys
    130                 135                 140                 
Thr Lys His Glu Leu His Ile Pro Lys Gly Tyr Arg Lys Asp Lys Phe
145                 150                 155                 160 
Val Trp Met Asp Tyr Leu Lys Ala Cys Lys Leu Gln Asn Ala Pro Lys
                165                 170                 175     
Lys Leu Phe Arg Asn Arg Ser Pro Asn Gly Pro Met Ser Lys Glu Phe
            180                 185                 190         
Gln Val Gly Met Lys Leu Glu Ala Val Asp Arg Lys Asn Pro Ser Leu
        195                 200                 205             
Val Cys Val Ala Thr Ile Ala Asp Ile Val Glu Asp Arg Leu Leu Val
    210                 215                 220                 
His Phe Asp Asn Trp Asp Asp Ser Tyr Asp Tyr Trp Cys Asp Val Asn
225                 230                 235                 240 
Ser Pro Tyr Val Gln Pro Val Gly Trp Cys Gln Glu Asn Gly Arg Thr
                245                 250                 255     
Leu Ile Ala Pro Gln Gly Tyr Pro Asn Pro Glu Asn Phe Ser Trp Thr
            260                 265                 270         
Glu Tyr Leu Glu Ala Thr Gln Thr Asn Ala Val Pro Ala Lys Val Phe
        275                 280                 285             
Lys Met Arg Leu Pro His Gly Phe Leu Pro Asn Met Lys Leu Glu Val
    290                 295                 300                 
Val Asp Lys Arg Asn Pro Arg Leu Ile Arg Val Ala Thr Ile Val Asp
305                 310                 315                 320 
Val Asp Asp Gln Arg Val Lys Val His Phe Asp Gly Trp Asp His Lys
                325                 330                 335     
Tyr Asp Tyr Trp Val Glu Ala Asp Ser Pro Asp Ile His Pro Ile Gly
            340                 345                 350         
Trp Cys Asp Val Thr Gly His Pro Leu Glu Val Pro Gln Arg Thr Asn
        355                 360                 365             
Asp Leu Lys Ile Leu Pro Gly Gln Ala Val Cys Pro Thr Pro Gly Cys
    370                 375                 380                 
Arg Gly Ile Gly His Ile Arg Gly Pro Arg Tyr Ser Gly His His Ser
385                 390                 395                 400 
Ala Phe Gly Cys Pro Tyr Ser Asp Met Asn Leu Lys Lys Glu Ala Thr
                405                 410                 415     
Leu His Asp Arg Leu Arg Glu Gln Thr Gln Ala Asn Leu Glu Ser Asp
            420                 425                 430         
Ser Ser His Ser Lys Ser Lys Ser Leu Cys Ser Leu Asn Phe Asn Gly
        435                 440                 445             
Lys His Glu Lys Val Asn Ser Gln Pro Arg Leu Val Gln Gln Ala Lys
    450                 455                 460                 
Cys Leu Lys Ile Lys Gly Lys Glu Asp Ile Asp Leu Asp Asn Leu Phe
465                 470                 475                 480 
Arg Gly Arg Val Arg Trp Leu Met Pro Val Ile Pro Ala Leu Trp Glu
                485                 490                 495     
Ala Glu Ala Gly Arg Ser Arg Asp Gln Glu Ile Lys Thr Ile Leu Ala
            500                 505                 510         
Asn Ala Val Lys Pro Arg Leu Tyr Gln Lys Tyr Lys Lys Leu Ala Arg
        515                 520                 525             
Arg Gly Gly Gly Cys Leu
    530                 


<210> 7200
<211> 623
<212> PRT
<213> Homo sapiens

<400> 7200
Met Lys Gln Pro Asn Arg Lys Arg Lys Leu Asn Met Asp Ser Lys Glu
 1               5                  10                  15      
Arg Leu Asp Gln Asp Gly Arg Leu Glu Gln Ala Glu Glu Glu Lys Lys
            20                  25                  30          
Pro Lys Asp Ser Thr Thr Pro Leu Ser His Val Pro Ser Ala Ala Ala
        35                  40                  45              
Gln Gly Ala Trp Ser Trp Glu Trp Tyr Leu Lys Glu Gln Lys Ala Val
    50                  55                  60                  
Ala Ala Pro Val Glu Leu Phe Ser Lys Asp Gln Ser Phe Pro Glu His
65                  70                  75                  80  
Glu Asn Gly Phe Gln Ile Gly Met Arg Leu Glu Gly Ile Asp Pro Arg
                85                  90                  95      
His Pro Ser Val Phe Cys Val Leu Ser Val Ala Glu Val Cys Gly Tyr
            100                 105                 110         
Arg Leu Arg Leu His Phe Asp Gly Tyr Leu Ser Cys Tyr Asp Phe Trp
        115                 120                 125             
Thr Asn Ala Gly Ser Pro Asp Ile His Pro Val Gly Trp Cys Glu Lys
    130                 135                 140                 
Thr Lys His Glu Leu His Ile Pro Lys Gly Tyr Arg Lys Asp Lys Phe
145                 150                 155                 160 
Val Trp Met Asp Tyr Leu Lys Ala Cys Lys Leu Gln Asn Ala Pro Lys
                165                 170                 175     
Lys Leu Phe Arg Asn Arg Ser Pro Asn Gly Pro Met Ser Lys Glu Phe
            180                 185                 190         
Gln Val Gly Met Lys Leu Glu Ala Val Asp Arg Lys Asn Pro Ser Leu
        195                 200                 205             
Val Cys Val Ala Thr Ile Ala Asp Ile Val Glu Asp Arg Leu Leu Val
    210                 215                 220                 
His Phe Asp Asn Trp Asp Asp Ser Tyr Asp Tyr Trp Cys Asp Val Asn
225                 230                 235                 240 
Ser Pro Tyr Val Gln Pro Val Gly Trp Cys Gln Glu Asn Gly Arg Thr
                245                 250                 255     
Leu Ile Ala Pro Gln Gly Tyr Pro Asn Pro Glu Asn Phe Ser Trp Thr
            260                 265                 270         
Glu Tyr Leu Glu Ala Thr Gln Thr Asn Ala Val Pro Ala Lys Val Phe
        275                 280                 285             
Lys Met Arg Leu Pro His Gly Phe Leu Pro Asn Met Lys Leu Glu Val
    290                 295                 300                 
Val Asp Lys Arg Asn Pro Arg Leu Ile Arg Val Ala Thr Ile Val Asp
305                 310                 315                 320 
Val Asp Asp Gln Arg Val Lys Val His Phe Asp Gly Trp Asp His Lys
                325                 330                 335     
Tyr Asp Tyr Trp Val Glu Ala Asp Ser Pro Asp Ile His Pro Ile Gly
            340                 345                 350         
Trp Cys Asp Val Thr Gly His Pro Leu Glu Val Pro Gln Arg Thr Asn
        355                 360                 365             
Asp Leu Lys Ile Leu Pro Gly Gln Ala Val Cys Pro Thr Pro Gly Cys
    370                 375                 380                 
Arg Gly Ile Gly His Ile Arg Gly Pro Arg Tyr Ser Gly His His Ser
385                 390                 395                 400 
Ala Phe Gly Cys Pro Tyr Ser Asp Met Asn Leu Lys Lys Glu Ala Thr
                405                 410                 415     
Leu His Asp Arg Leu Arg Glu Gln Thr Gln Ala Asn Leu Glu Ser Asp
            420                 425                 430         
Ser Ser His Ser Lys Ser Lys Ser Leu Cys Ser Leu Asn Phe Asn Gly
        435                 440                 445             
Lys His Glu Lys Val Asn Ser Gln Pro Arg Leu Val Gln Gln Ala Lys
    450                 455                 460                 
Cys Leu Lys Ile Lys Gly Lys Glu Asp Ile Asp Leu Asp Asn Leu Phe
465                 470                 475                 480 
Arg Val Leu Val Leu His Pro Arg Gly Leu Glu Tyr Ser Val Glu Gln
                485                 490                 495     
Ala Gln Gln Val Leu His Gln Pro Val Ser Met Ser Thr Val Ser Ala
            500                 505                 510         
His Pro Phe Arg Asp Leu Pro Leu Gly Arg Glu Gln His Cys Lys Leu
        515                 520                 525             
Leu Pro Gly Val Ala Asp Ile Arg Ala Ser Gln Val Ala Arg Trp Thr
    530                 535                 540                 
Val Asp Glu Val Ala Glu Phe Val Gln Ser Leu Leu Gly Cys Glu Glu
545                 550                 555                 560 
His Ala Lys Cys Phe Lys Lys Glu Gln Ile Asp Gly Lys Ala Phe Leu
                565                 570                 575     
Leu Leu Thr Gln Thr Asp Ile Val Lys Val Met Lys Ile Lys Leu Gly
            580                 585                 590         
Pro Ala Leu Lys Ile Tyr Asn Ser Ile Leu Met Phe Arg His Ser Gln
        595                 600                 605             
Glu Leu Pro Glu Glu Asp Ile Ala Ser Asp Gln Glu Val Arg Gly
    610                 615                 620             


<210> 7201
<211> 782
<212> PRT
<213> Homo sapiens

<400> 7201
Met Thr Ser Ile Ile Lys Leu Thr Thr Leu Ser Gly Val Gln Glu Glu
 1               5                  10                  15      
Ser Ala Leu Cys Tyr Leu Leu Gln Val Asp Glu Phe Arg Phe Leu Leu
            20                  25                  30          
Asp Cys Gly Trp Asp Glu His Phe Ser Met Asp Ile Ile Asp Ser Leu
        35                  40                  45              
Arg Lys His Val His Gln Ile Asp Ala Val Leu Leu Ser His Pro Asp
    50                  55                  60                  
Pro Leu His Leu Gly Ala Leu Pro Tyr Ala Val Gly Lys Leu Gly Leu
65                  70                  75                  80  
Asn Cys Ala Ile Tyr Ala Thr Ile Pro Val Tyr Lys Met Gly Gln Met
                85                  90                  95      
Phe Met Tyr Asp Leu Tyr Gln Ser Arg His Asn Thr Glu Asp Phe Thr
            100                 105                 110         
Leu Phe Thr Leu Asp Asp Val Asp Ala Ala Phe Asp Lys Ile Gln Gln
        115                 120                 125             
Leu Lys Phe Ser Gln Ile Val Asn Leu Lys Gly Lys Gly His Gly Leu
    130                 135                 140                 
Ser Ile Thr Pro Leu Pro Ala Gly His Met Ile Gly Gly Thr Ile Trp
145                 150                 155                 160 
Lys Ile Val Lys Asp Gly Glu Glu Glu Ile Val Tyr Ala Val Asp Phe
                165                 170                 175     
Asn His Lys Arg Glu Ile His Leu Asn Gly Cys Ser Leu Glu Met Leu
            180                 185                 190         
Ser Arg Pro Ser Leu Leu Ile Thr Asp Ser Phe Asn Ala Thr Tyr Val
        195                 200                 205             
Gln Pro Arg Arg Lys Gln Arg Asp Glu Gln Leu Leu Thr Asn Val Leu
    210                 215                 220                 
Glu Thr Leu Arg Gly Asp Gly Asn Val Leu Ile Ala Val Asp Thr Ala
225                 230                 235                 240 
Gly Arg Val Leu Glu Leu Ala Gln Leu Leu Asp Gln Ile Trp Arg Thr
                245                 250                 255     
Lys Asp Ala Gly Leu Gly Val Tyr Ser Leu Ala Leu Leu Asn Asn Val
            260                 265                 270         
Ser Tyr Asn Val Val Glu Phe Ser Lys Ser Gln Val Glu Trp Met Ser
        275                 280                 285             
Asp Lys Leu Met Arg Cys Phe Glu Asp Lys Arg Asn Asn Pro Phe Gln
    290                 295                 300                 
Phe Arg His Leu Ser Leu Cys His Gly Leu Ser Asp Leu Ala Arg Val
305                 310                 315                 320 
Pro Ser Pro Lys Val Val Leu Ala Ser Gln Pro Asp Leu Glu Cys Gly
                325                 330                 335     
Phe Ser Arg Asp Leu Phe Ile Gln Trp Cys Gln Asp Pro Lys Asn Ser
            340                 345                 350         
Ile Ile Leu Thr Tyr Arg Thr Thr Pro Gly Thr Leu Ala Arg Phe Leu
        355                 360                 365             
Ile Asp Asn Pro Ser Glu Lys Ile Thr Glu Ile Glu Leu Arg Lys Arg
    370                 375                 380                 
Val Lys Leu Glu Gly Lys Glu Leu Glu Glu Tyr Leu Glu Lys Glu Lys
385                 390                 395                 400 
Leu Lys Lys Glu Ala Ala Lys Lys Leu Glu Gln Ser Lys Glu Ala Asp
                405                 410                 415     
Ile Asp Ser Ser Asp Glu Ser Asp Ile Glu Glu Asp Ile Asp Gln Pro
            420                 425                 430         
Ser Ala His Lys Thr Lys His Asp Leu Met Met Lys Gly Glu Gly Ser
        435                 440                 445             
Arg Lys Gly Ser Phe Phe Lys Gln Ala Lys Lys Ser Tyr Pro Met Phe
    450                 455                 460                 
Pro Ala Pro Glu Glu Arg Ile Lys Trp Asp Glu Tyr Gly Glu Ile Ile
465                 470                 475                 480 
Lys Pro Glu Asp Phe Leu Val Pro Glu Leu Gln Ala Thr Glu Glu Glu
                485                 490                 495     
Lys Ser Lys Leu Glu Ser Gly Leu Thr Asn Gly Asp Glu Pro Met Asp
            500                 505                 510         
Gln Asp Leu Ser Asp Val Pro Thr Lys Cys Ile Ser Thr Thr Glu Ser
        515                 520                 525             
Ile Glu Ile Lys Ala Arg Val Thr Tyr Ile Asp Tyr Glu Gly Arg Ser
    530                 535                 540                 
Asp Gly Asp Ser Ile Lys Lys Ile Ile Asn Gln Met Lys Pro Arg Gln
545                 550                 555                 560 
Leu Ile Ile Val His Gly Pro Pro Glu Ala Ser Gln Asp Leu Ala Glu
                565                 570                 575     
Cys Cys Arg Ala Phe Gly Gly Lys Asp Ile Lys Val Tyr Met Pro Lys
            580                 585                 590         
Leu His Glu Thr Val Asp Ala Thr Ser Glu Thr His Ile Tyr Gln Val
        595                 600                 605             
Arg Leu Lys Asp Ser Leu Val Ser Ser Leu Gln Phe Cys Lys Ala Lys
    610                 615                 620                 
Asp Ala Glu Leu Ala Trp Ile Asp Gly Val Leu Asp Met Arg Val Ser
625                 630                 635                 640 
Lys Val Asp Thr Gly Val Ile Leu Glu Glu Gly Glu Leu Lys Asp Asp
                645                 650                 655     
Gly Glu Asp Ser Glu Met Gln Val Glu Ala Pro Ser Asp Ser Ser Val
            660                 665                 670         
Ile Ala Gln Gln Lys Ala Met Lys Ser Leu Phe Gly Asp Asp Glu Lys
        675                 680                 685             
Glu Thr Gly Glu Glu Ser Glu Ile Ile Pro Thr Leu Glu Pro Leu Pro
    690                 695                 700                 
Pro His Glu Val Pro Gly His Gln Ser Val Phe Met Asn Glu Pro Arg
705                 710                 715                 720 
Leu Ser Asp Phe Lys Gln Val Leu Leu Arg Glu Gly Ile Gln Ala Glu
                725                 730                 735     
Phe Val Gly Gly Val Leu Val Cys Asn Asn Gln Val Ala Val Arg Arg
            740                 745                 750         
Thr Glu Thr Gly Arg Ile Gly Leu Glu Gly Cys Leu Cys Gln Asp Phe
        755                 760                 765             
Tyr Arg Ile Arg Asp Leu Leu Tyr Glu Gln Tyr Ala Ile Val
    770                 775                 780         


<210> 7202
<211> 925
<212> PRT
<213> Homo sapiens

<400> 7202
Glu Leu Gly Ala Gly Arg Ser Asp Arg Glu Ala Met Glu Ala Ala Val
 1               5                  10                  15      
Lys Glu Glu Ile Ser Val Glu Asp Glu Ala Val Asp Lys Asn Ile Phe
            20                  25                  30          
Arg Asp Cys Asn Lys Ile Ala Phe Tyr Arg Arg Gln Lys Gln Trp Leu
        35                  40                  45              
Ser Lys Lys Ser Thr Tyr Arg Ala Leu Leu Asp Ser Val Thr Thr Asp
    50                  55                  60                  
Glu Asp Ser Thr Arg Phe Gln Ile Ile Asn Glu Ala Ser Lys Val Pro
65                  70                  75                  80  
Leu Leu Ala Glu Ile Tyr Gly Ile Glu Gly Asn Ile Phe Arg Leu Lys
                85                  90                  95      
Ile Asn Glu Glu Thr Pro Leu Lys Pro Arg Phe Glu Val Pro Asp Val
            100                 105                 110         
Leu Thr Ser Lys Pro Ser Thr Val Arg Leu Ile Ser Cys Ser Gly Asp
        115                 120                 125             
Thr Gly Ser Leu Ile Leu Ala Asp Gly Lys Gly Asp Leu Lys Cys His
    130                 135                 140                 
Ile Thr Ala Asn Pro Phe Lys Val Asp Leu Val Ser Glu Glu Glu Val
145                 150                 155                 160 
Val Ile Ser Ile Asn Ser Leu Gly Gln Leu Tyr Phe Glu His Leu Gln
                165                 170                 175     
Ile Leu His Lys Gln Arg Ala Ala Lys Glu Asn Glu Glu Glu Thr Ser
            180                 185                 190         
Val Asp Thr Ser Gln Glu Asn Gln Glu Asp Leu Gly Leu Trp Glu Glu
        195                 200                 205             
Lys Phe Gly Lys Phe Val Asp Ile Lys Ala Asn Gly Pro Ser Ser Ile
    210                 215                 220                 
Gly Leu Asp Phe Ser Leu His Gly Phe Glu His Leu Tyr Gly Ile Pro
225                 230                 235                 240 
Gln His Ala Glu Ser His Gln Leu Lys Asn Thr Gly Asp Gly Asp Ala
                245                 250                 255     
Tyr Arg Leu Tyr Asn Leu Asp Val Tyr Gly Tyr Gln Ile Tyr Asp Lys
            260                 265                 270         
Met Gly Ile Tyr Gly Ser Val Pro Tyr Leu Leu Ala His Lys Leu Gly
        275                 280                 285             
Arg Thr Ile Gly Ile Phe Trp Leu Asn Ala Ser Glu Thr Leu Val Glu
    290                 295                 300                 
Ile Asn Thr Glu Pro Ala Val Glu Tyr Thr Leu Thr Gln Met Gly Pro
305                 310                 315                 320 
Val Ala Ala Lys Gln Lys Val Arg Ser Arg Thr His Val His Trp Met
                325                 330                 335     
Ser Glu Ser Gly Ile Ile Asp Val Phe Leu Leu Thr Gly Pro Thr Pro
            340                 345                 350         
Ser Asp Val Phe Lys Gln Tyr Ser His Leu Thr Gly Thr Gln Ala Met
        355                 360                 365             
Pro Pro Leu Phe Ser Leu Gly Tyr His Gln Cys Arg Trp Asn Tyr Glu
    370                 375                 380                 
Asp Glu Gln Asp Val Lys Ala Val Asp Ala Gly Phe Asp Glu His Asp
385                 390                 395                 400 
Ile Pro Tyr Asp Ala Met Trp Leu Asp Ile Glu His Thr Glu Gly Lys
                405                 410                 415     
Arg Tyr Phe Thr Trp Asp Lys Asn Arg Phe Pro Asn Pro Lys Arg Met
            420                 425                 430         
Gln Glu Leu Leu Arg Ser Lys Lys Arg Lys Leu Val Val Ile Ser Asp
        435                 440                 445             
Pro His Ile Lys Ile Asp Pro Asp Tyr Ser Val Tyr Val Lys Ala Lys
    450                 455                 460                 
Asp Gln Gly Phe Phe Val Lys Asn Gln Glu Gly Glu Asp Phe Glu Gly
465                 470                 475                 480 
Val Cys Trp Pro Gly Leu Ser Ser Tyr Leu Asp Phe Thr Asn Pro Lys
                485                 490                 495     
Val Arg Glu Trp Tyr Ser Ser Leu Phe Ala Phe Pro Val Tyr Gln Gly
            500                 505                 510         
Ser Thr Asp Ile Leu Phe Leu Trp Asn Asp Met Asn Glu Pro Ser Val
        515                 520                 525             
Phe Arg Gly Pro Glu Gln Thr Met Gln Lys Asn Ala Ile His His Gly
    530                 535                 540                 
Asn Trp Glu His Arg Glu Leu His Asn Ile Tyr Gly Phe Tyr His Gln
545                 550                 555                 560 
Met Ala Thr Ala Glu Gly Leu Ile Lys Arg Ser Lys Gly Lys Glu Arg
                565                 570                 575     
Pro Phe Val Leu Thr Arg Ser Phe Phe Ala Gly Ser Gln Lys Tyr Gly
            580                 585                 590         
Ala Val Trp Thr Gly Asp Asn Thr Ala Glu Trp Ser Asn Leu Lys Ile
        595                 600                 605             
Ser Ile Pro Met Leu Leu Thr Leu Ser Ile Thr Gly Ile Ser Phe Cys
    610                 615                 620                 
Gly Ala Asp Ile Gly Gly Phe Ile Gly Asn Pro Glu Thr Glu Leu Leu
625                 630                 635                 640 
Val Arg Trp Tyr Gln Ala Gly Ala Tyr Gln Pro Phe Phe Arg Gly His
                645                 650                 655     
Ala Thr Met Asn Thr Lys Arg Arg Glu Pro Trp Leu Phe Gly Glu Glu
            660                 665                 670         
His Thr Arg Leu Ile Arg Glu Ala Ile Arg Glu Arg Tyr Gly Leu Leu
        675                 680                 685             
Pro Tyr Trp Tyr Ser Leu Phe Tyr His Ala His Val Ala Ser Gln Pro
    690                 695                 700                 
Val Met Arg Pro Leu Trp Val Glu Phe Pro Asp Glu Leu Lys Thr Phe
705                 710                 715                 720 
Asp Met Glu Asp Glu Tyr Met Leu Gly Ser Ala Leu Leu Val His Pro
                725                 730                 735     
Val Thr Glu Pro Lys Ala Thr Thr Val Asp Val Phe Leu Pro Gly Ser
            740                 745                 750         
Asn Glu Val Trp Tyr Asp Tyr Lys Thr Phe Ala His Trp Glu Gly Gly
        755                 760                 765             
Cys Thr Val Lys Ile Pro Val Ala Leu Asp Thr Ile Pro Val Phe Gln
    770                 775                 780                 
Arg Gly Gly Ser Val Ile Pro Ile Lys Thr Thr Val Gly Lys Ser Thr
785                 790                 795                 800 
Gly Trp Met Thr Glu Ser Ser Tyr Gly Leu Arg Val Ala Leu Ser Thr
                805                 810                 815     
Lys Gly Ser Ser Val Gly Glu Leu Tyr Leu Asp Asp Gly His Ser Phe
            820                 825                 830         
Gln Tyr Leu His Gln Lys Gln Phe Leu His Arg Lys Phe Ser Phe Cys
        835                 840                 845             
Ser Ser Val Leu Ile Asn Ser Phe Ala Asp Gln Arg Gly His Tyr Pro
    850                 855                 860                 
Ser Lys Cys Val Val Glu Lys Ile Leu Val Leu Gly Phe Arg Lys Glu
865                 870                 875                 880 
Pro Ser Ser Val Thr Thr His Ser Ser Asp Gly Lys Asp Gln Pro Val
                885                 890                 895     
Ala Phe Thr Tyr Cys Ala Lys Thr Ser Ile Leu Ser Leu Glu Lys Leu
            900                 905                 910         
Ser Leu Asn Ile Ala Thr Asp Trp Glu Val Arg Ile Ile
        915                 920                 925 


<210> 7203
<211> 462
<212> PRT
<213> Homo sapiens

<400> 7203
Met Gly Pro Asp Arg Val Thr Ala Arg Glu Leu Cys Glu Asn Asp Asp
 1               5                  10                  15      
Leu Ala Thr Ser Leu Val Leu Asp Pro Tyr Leu Gly Phe Arg Thr His
            20                  25                  30          
Lys Met Asn Val Ser Pro Val Pro Pro Leu Arg Arg Gln Gln His Leu
        35                  40                  45              
Arg Ser Ala Leu Glu Thr Phe Leu Arg Gln Arg Asp Leu Glu Ala Ala
    50                  55                  60                  
Tyr Arg Ala Leu Thr Leu Gly Gly Trp Thr Ala Arg Tyr Phe Gln Ser
65                  70                  75                  80  
Arg Gly Pro Arg Gln Glu Ala Ala Leu Lys Thr His Val Tyr Arg Tyr
                85                  90                  95      
Leu Arg Ala Phe Leu Pro Glu Ser Gly Phe Thr Ile Leu Pro Cys Thr
            100                 105                 110         
Arg Tyr Ser Met Glu Thr Asn Gly Ala Lys Ile Val Ser Thr Arg Ala
        115                 120                 125             
Trp Lys Lys Asn Glu Lys Leu Glu Leu Leu Val Gly Cys Ile Ala Glu
    130                 135                 140                 
Leu Arg Glu Ala Asp Glu Gly Leu Leu Arg Ala Gly Glu Asn Asp Phe
145                 150                 155                 160 
Ser Ile Met Tyr Ser Thr Arg Lys Arg Ser Ala Gln Leu Trp Leu Gly
                165                 170                 175     
Pro Ala Ala Phe Ile Asn His Asp Cys Lys Pro Asn Cys Lys Phe Val
            180                 185                 190         
Pro Ala Asp Gly Asn Ala Ala Cys Val Lys Val Leu Arg Asp Ile Glu
        195                 200                 205             
Pro Gly Asp Glu Val Thr Cys Phe Tyr Gly Glu Gly Phe Phe Gly Glu
    210                 215                 220                 
Lys Asn Glu His Cys Glu Cys His Thr Cys Glu Arg Lys Gly Glu Gly
225                 230                 235                 240 
Ala Phe Arg Thr Arg Pro Arg Glu Pro Ala Leu Pro Pro Arg Pro Leu
                245                 250                 255     
Asp Lys Tyr Gln Leu Arg Glu Thr Lys Arg Arg Leu Gln Gln Gly Leu
            260                 265                 270         
Asp Ser Gly Ser Arg Gln Gly Leu Leu Gly Pro Arg Ala Cys Val His
        275                 280                 285             
Pro Ser Pro Leu Arg Arg Asp Pro Phe Cys Ala Ala Cys Gln Pro Leu
    290                 295                 300                 
Arg Leu Pro Ala Cys Ser Ala Arg Pro Asp Thr Ser Pro Leu Trp Leu
305                 310                 315                 320 
Gln Trp Leu Pro Gln Pro Gln Pro Arg Val Arg Pro Arg Lys Arg Arg
                325                 330                 335     
Arg Pro Arg Pro Arg Arg Ala Pro Val Leu Ser Thr His His Ala Ala
            340                 345                 350         
Arg Val Ser Leu His Arg Trp Gly Gly Cys Gly Pro His Cys Arg Leu
        355                 360                 365             
Arg Gly Glu Ala Leu Val Ala Leu Gly Gln Pro Pro His Ala Arg Trp
    370                 375                 380                 
Ala Pro Gln Gln Asp Trp His Trp Ala Arg Arg Tyr Gly Leu Pro Tyr
385                 390                 395                 400 
Val Val Arg Val Asp Leu Arg Arg Leu Ala Pro Ala Pro Pro Ala Thr
                405                 410                 415     
Pro Ala Pro Ala Gly Thr Pro Gly Pro Ile Leu Ile Pro Lys Gln Ala
            420                 425                 430         
Leu Ala Phe Ala Pro Phe Ser Pro Pro Lys Arg Leu Arg Leu Val Val
        435                 440                 445             
Ser His Gly Ser Ile Asp Leu Asp Val Gly Gly Glu Glu Leu
    450                 455                 460         


<210> 7204
<211> 409
<212> PRT
<213> Homo sapiens

<400> 7204
Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro
 1               5                  10                  15      
Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly
            20                  25                  30          
Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln
        35                  40                  45              
Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr
    50                  55                  60                  
Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly
65                  70                  75                  80  
Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly Thr Gly Pro
                85                  90                  95      
Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro Gly
            100                 105                 110         
Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln
        115                 120                 125             
Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr
    130                 135                 140                 
Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly
145                 150                 155                 160 
Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro
                165                 170                 175     
Ser Thr Gly Gln Asn Pro Thr Arg Thr Gly Leu Asn Pro Gly Thr Gly
            180                 185                 190         
Gln His Pro Thr Arg Thr Gly Ser Asn Pro Asp Thr Gly Gln Asn Pro
        195                 200                 205             
Thr Arg Thr Gly Ser Asn Pro Ser Thr Gly Gln Asn Pro Thr Arg Thr
    210                 215                 220                 
Gly Leu Asn Pro Gly Thr Gly Gln His Pro Thr Arg Thr Gly Ser Asn
225                 230                 235                 240 
Pro Asp Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala
                245                 250                 255     
Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn
            260                 265                 270         
Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg
        275                 280                 285             
Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Glu Ser
    290                 295                 300                 
Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly
305                 310                 315                 320 
Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro Gly Thr Gly Gln
                325                 330                 335     
Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr
            340                 345                 350         
Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly
        355                 360                 365             
Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro
    370                 375                 380                 
Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro Gly Thr Gly
385                 390                 395                 400 
Gln Asn Pro Thr Arg Thr Gly Pro Asn
                405                 


<210> 7205
<211> 760
<212> PRT
<213> Homo sapiens

<400> 7205
Ser Ser Thr Gly Gln Asn Pro Thr Arg Thr Gly Leu Asn Pro Gly Thr
 1               5                  10                  15      
Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn
            20                  25                  30          
Pro Thr Arg Thr Gly Leu Asn Pro Gly Thr Gly Gln His Pro Thr Arg
        35                  40                  45              
Thr Gly Ser Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Leu
    50                  55                  60                  
Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly
65                  70                  75                  80  
Thr Gly Gln Asn Pro Thr Arg Thr Gly Leu Asn Pro Gly Thr Gly Gln
                85                  90                  95      
Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr
            100                 105                 110         
Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly
        115                 120                 125             
Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro
    130                 135                 140                 
Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly Thr Gly Ser Asn Pro Gly
145                 150                 155                 160 
Thr Gly Gln Asn Pro Thr Arg Thr Gly Leu Asn Pro Gly Thr Gly Gln
                165                 170                 175     
Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr
            180                 185                 190         
Arg Thr Gly Ser Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly
        195                 200                 205             
Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro
    210                 215                 220                 
Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly
225                 230                 235                 240 
Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro Ser Thr Gly Gln Asn Pro
                245                 250                 255     
Thr Arg Thr Gly Leu Asn Pro Gly Thr Gly Gln His Pro Thr Arg Thr
            260                 265                 270         
Gly Ser Asn Pro Asp Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn
        275                 280                 285             
Pro Ser Thr Gly Gln Asn Pro Thr Arg Thr Gly Leu Asn Pro Gly Thr
    290                 295                 300                 
Gly Gln His Pro Thr Arg Thr Gly Ser Asn Pro Asp Thr Gly Gln Asn
305                 310                 315                 320 
Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg
                325                 330                 335     
Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly Leu
            340                 345                 350         
Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly
        355                 360                 365             
Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro Ser Thr Gly Gln
    370                 375                 380                 
Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr
385                 390                 395                 400 
Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr Gly
                405                 410                 415     
Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Thr Pro Pro
            420                 425                 430         
Gly Leu Gly Ser Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly
        435                 440                 445             
Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro
    450                 455                 460                 
Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly
465                 470                 475                 480 
Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro
                485                 490                 495     
Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln Asn Pro Thr Arg Thr
            500                 505                 510         
Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn
        515                 520                 525             
Pro Ser Thr Gly Gln Asn Pro Thr Arg Thr Gly Leu Asn Pro Gly Thr
    530                 535                 540                 
Gly Gln His Pro Thr Arg Thr Gly Ser Asn Pro Asp Thr Gly Gln Asn
545                 550                 555                 560 
Pro Thr Arg Thr Gly Ser Asn Pro Ser Thr Gly Gln Asn Pro Thr Arg
                565                 570                 575     
Thr Gly Leu Asn Pro Gly Thr Gly Gln His Pro Thr Arg Thr Gly Ser
            580                 585                 590         
Asn Pro Asp Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly
        595                 600                 605             
Ala Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Ala Gly Gln
    610                 615                 620                 
Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr
625                 630                 635                 640 
Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Glu
                645                 650                 655     
Ser Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro
            660                 665                 670         
Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro Gly Thr Gly
        675                 680                 685             
Gln Asn Pro Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro
    690                 695                 700                 
Thr Arg Thr Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr
705                 710                 715                 720 
Gly Pro Asn Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Pro Asn
                725                 730                 735     
Pro Gly Thr Gly Gln Asn Pro Thr Arg Thr Gly Ser Asn Pro Gly Thr
            740                 745                 750         
Gly Gln Asn Pro Thr Arg Thr Gly
        755                 760 


<210> 7206
<211> 1131
<212> PRT
<213> Homo sapiens

<400> 7206
Met Phe Gln Ile Pro Val Glu Asn Leu Asp Asn Ile Arg Lys Val Arg
 1               5                  10                  15      
Lys Lys Val Lys Gly Ile Leu Val Asp Ile Gly Leu Asp Ser Cys Lys
            20                  25                  30          
Glu Leu Leu Lys Asp Leu Lys Gly Phe Asp Pro Gly Glu Lys Tyr Phe
        35                  40                  45              
His Asn Thr Ser Trp Gly Asp Val Ser Leu Trp Glu Pro Ser Gly Lys
    50                  55                  60                  
Lys Val Arg Tyr Arg Thr Lys Pro Tyr Cys Cys Gly Leu Cys Lys Tyr
65                  70                  75                  80  
Ser Thr Lys Val Leu Thr Ser Phe Lys Asn His Leu His Arg Tyr His
                85                  90                  95      
Glu Asp Glu Ile Asp Gln Glu Leu Val Ile Pro Cys Pro Asn Cys Val
            100                 105                 110         
Phe Ala Ser Gln Pro Lys Val Val Gly Arg His Phe Arg Met Phe His
        115                 120                 125             
Ala Pro Val Arg Lys Val Gln Asn Tyr Thr Val Asn Ile Leu Gly Glu
    130                 135                 140                 
Thr Lys Ser Ser Arg Ser Asp Val Ile Ser Phe Thr Cys Leu Lys Cys
145                 150                 155                 160 
Asn Phe Ser Asn Thr Leu Tyr Tyr Ser Met Lys Lys His Val Leu Val
                165                 170                 175     
Ala His Phe His Tyr Leu Ile Asn Ser Tyr Phe Gly Leu Arg Thr Glu
            180                 185                 190         
Glu Met Gly Glu Gln Pro Lys Thr Asn Asp Thr Val Ser Ile Glu Lys
        195                 200                 205             
Ile Pro Pro Pro Asp Lys Tyr Tyr Cys Lys Lys Cys Asn Ala Asn Ala
    210                 215                 220                 
Ser Ser Gln Asp Ala Leu Met Tyr His Ile Leu Thr Ser Asp Ile His
225                 230                 235                 240 
Arg Asp Leu Glu Asn Lys Leu Arg Ser Val Ile Ser Glu His Ile Lys
                245                 250                 255     
Arg Thr Gly Leu Leu Lys Gln Thr His Ile Ala Pro Lys Pro Ala Ala
            260                 265                 270         
His Leu Ala Ala Pro Ala Asn Gly Ser Ala Pro Ser Ala Pro Ala Gln
        275                 280                 285             
Pro Pro Cys Phe His Leu Ala Leu Pro Gln Asn Ser Pro Ser Pro Ala
    290                 295                 300                 
Ala Gly Gln Pro Val Thr Val Ala Gln Gly Ala Pro Gly Ser Leu Thr
305                 310                 315                 320 
His Ser Pro Pro Ala Ala Gly Gln Ser His Met Thr Leu Val Ser Ser
                325                 330                 335     
Pro Leu Pro Val Gly Gln Asn Ser Leu Thr Leu Gln Pro Pro Ala Pro
            340                 345                 350         
Gln Pro Val Phe Leu Ser His Gly Val Pro Leu His Gln Ser Val Asn
        355                 360                 365             
Pro Pro Val Leu Pro Leu Ser Gln Pro Val Gly Pro Val Asn Lys Ser
    370                 375                 380                 
Val Gly Thr Ser Val Leu Pro Ile Asn Gln Thr Val Arg Pro Gly Val
385                 390                 395                 400 
Leu Pro Leu Thr Gln Pro Val Gly Pro Ile Asn Arg Pro Val Gly Pro
                405                 410                 415     
Gly Val Leu Pro Val Ser Pro Ser Val Thr Pro Gly Val Leu Gln Ala
            420                 425                 430         
Val Ser Pro Gly Val Leu Ser Val Ser Arg Ala Val Pro Ser Gly Val
        435                 440                 445             
Leu Pro Ala Gly Gln Met Thr Pro Ala Gly Gln Met Thr Pro Ala Gly
    450                 455                 460                 
Val Ile Pro Gly Gln Thr Ala Thr Ser Gly Val Leu Pro Thr Gly Gln
465                 470                 475                 480 
Met Val Gln Ser Gly Val Leu Pro Val Gly Gln Thr Ala Pro Ser Arg
                485                 490                 495     
Val Leu Pro Pro Gly Gln Thr Ala Pro Leu Arg Val Ile Ser Ala Gly
            500                 505                 510         
Gln Val Val Pro Ser Gly Leu Leu Ser Pro Asn Gln Thr Val Ser Ser
        515                 520                 525             
Ser Ala Val Val Pro Val Asn Gln Gly Val Asn Ser Gly Val Leu Gln
    530                 535                 540                 
Leu Ser Gln Pro Val Val Ser Gly Val Leu Pro Val Gly Gln Pro Val
545                 550                 555                 560 
Arg Pro Gly Val Leu Gln Leu Asn Gln Thr Val Gly Thr Asn Ile Leu
                565                 570                 575     
Pro Val Asn Gln Pro Val Arg Pro Gly Ala Ser Gln Asn Thr Thr Phe
            580                 585                 590         
Leu Thr Ser Gly Ser Ile Leu Arg Gln Leu Ile Pro Thr Gly Lys Gln
        595                 600                 605             
Val Asn Gly Ile Pro Thr Tyr Thr Leu Ala Pro Val Ser Val Thr Leu
    610                 615                 620                 
Pro Val Pro Pro Gly Gly Leu Ala Thr Val Ala Pro Pro Gln Met Pro
625                 630                 635                 640 
Ile Gln Leu Leu Pro Ser Gly Ala Ala Ala Pro Met Ala Gly Ser Met
                645                 650                 655     
Pro Gly Met Pro Ser Pro Pro Val Leu Val Asn Ala Ala Gln Ser Val
            660                 665                 670         
Phe Val Gln Ala Ser Ser Ser Ala Ala Asp Thr Asn Gln Val Leu Lys
        675                 680                 685             
Gln Ala Lys Gln Trp Lys Thr Cys Pro Val Cys Asn Glu Leu Phe Pro
    690                 695                 700                 
Ser Asn Val Tyr Gln Val His Met Glu Val Ala His Lys His Ser Glu
705                 710                 715                 720 
Ser Lys Ser Gly Glu Lys Leu Glu Pro Glu Lys Leu Ala Ala Cys Ala
                725                 730                 735     
Pro Phe Leu Lys Trp Met Arg Glu Lys Thr Val Arg Cys Leu Ser Cys
            740                 745                 750         
Lys Cys Leu Val Ser Glu Glu Glu Leu Ile His His Leu Leu Met His
        755                 760                 765             
Gly Leu Gly Cys Leu Phe Cys Pro Cys Thr Phe His Asp Ile Lys Gly
    770                 775                 780                 
Leu Ser Glu His Ser Arg Asn Arg His Leu Gly Lys Lys Lys Leu Pro
785                 790                 795                 800 
Met Asp Tyr Ser Asn Arg Gly Phe Gln Leu Asp Val Asp Ala Asn Gly
                805                 810                 815     
Asn Leu Leu Phe Pro His Leu Asp Phe Ile Thr Ile Leu Pro Lys Glu
            820                 825                 830         
Lys Leu Gly Glu Arg Glu Val Tyr Leu Ala Ile Leu Ala Gly Ile His
        835                 840                 845             
Ser Lys Ser Leu Val Pro Val Tyr Val Lys Val Arg Pro Gln Ala Glu
    850                 855                 860                 
Gly Thr Pro Gly Ser Thr Gly Lys Arg Val Ser Thr Cys Pro Phe Cys
865                 870                 875                 880 
Phe Gly Pro Phe Val Thr Thr Glu Ala Tyr Glu Leu His Leu Lys Glu
                885                 890                 895     
Arg His His Ile Met Pro Thr Val His Thr Val Leu Lys Ser Pro Ala
            900                 905                 910         
Phe Lys Cys Ile His Cys Cys Gly Val Tyr Thr Gly Asn Met Thr Leu
        915                 920                 925             
Ala Ala Ile Ala Val His Leu Val Arg Cys Arg Ser Ala Pro Lys Asp
    930                 935                 940                 
Ser Ser Ser Asp Leu Gln Ala Gln Pro Gly Phe Ile His Asn Ser Glu
945                 950                 955                 960 
Leu Leu Leu Val Ser Gly Glu Val Met His Asp Ser Ser Phe Ser Val
                965                 970                 975     
Lys Arg Lys Leu Pro Asp Gly His Leu Gly Ala Glu Asp Gln Arg His
            980                 985                 990         
Gly Glu Glu Gln Pro Pro Ile Leu Asn Ala Asp Ala Ala Pro Gly Pro
        995                 1000                1005            
Glu Lys Val Thr Ser Val Val Pro Phe Lys Arg Gln Arg Asn Glu Ser
    1010                1015                1020                
Arg Thr Glu Gly Pro Ile Val Lys Asp Glu Ala Leu Gln Ile Leu Ala
1025                1030                1035                1040
Leu Asp Pro Lys Lys Tyr Glu Gly Arg Ser Tyr Glu Glu Lys Lys Gln
                1045                1050                1055    
Phe Leu Lys Asp Tyr Phe His Lys Lys Pro Tyr Pro Ser Lys Lys Glu
            1060                1065                1070        
Ile Glu Leu Leu Ser Ser Leu Phe Trp Val Trp Lys Ile Asp Val Ala
        1075                1080                1085            
Ser Phe Phe Gly Lys Arg Arg Tyr Ile Cys Met Lys Ala Ile Lys Asn
    1090                1095                1100                
His Lys Pro Ser Val Leu Leu Gly Phe Asp Met Ser Glu Leu Lys Asn
1105                1110                1115                1120
Val Lys His Arg Leu Asn Phe Glu Tyr Glu Pro
                1125                1130    


<210> 7207
<211> 670
<212> PRT
<213> Homo sapiens

<400> 7207
Met Gly Glu Thr Lys Ile Ile Tyr His Met Asp Glu Glu Glu Thr Pro
 1               5                  10                  15      
Tyr Leu Val Lys Leu Pro Val Ala Pro Glu Arg Val Thr Leu Ala Asp
            20                  25                  30          
Phe Lys Asn Val Leu Ser Asn Arg Pro Val His Ala Tyr Lys Phe Phe
        35                  40                  45              
Phe Lys Ser Met Asp Gln Asp Phe Gly Val Val Lys Glu Glu Ile Phe
    50                  55                  60                  
Asp Asp Asn Ala Lys Leu Pro Cys Phe Asn Gly Arg Val Val Ser Trp
65                  70                  75                  80  
Leu Val Leu Ala Glu Gly Ala His Ser Asp Ala Gly Ser Gln Gly Thr
                85                  90                  95      
Asp Ser His Thr Asp Leu Pro Pro Pro Leu Glu Arg Thr Gly Gly Ile
            100                 105                 110         
Gly Asp Ser Arg Pro Pro Ser Phe His Pro Asn Val Ala Ser Ser Arg
        115                 120                 125             
Asp Gly Met Asp Asn Glu Thr Gly Thr Glu Ser Met Val Ser His Arg
    130                 135                 140                 
Arg Glu Arg Ala Arg Arg Arg Asn Arg Glu Glu Ala Pro Arg Thr Asn
145                 150                 155                 160 
Gly His Pro Arg Gly Asp Arg Arg Arg Asp Val Gly Leu Pro Pro Asp
                165                 170                 175     
Ser Ala Ser Thr Ala Leu Ser Ser Glu Leu Glu Ser Ser Ser Phe Val
            180                 185                 190         
Asp Ser Asp Glu Asp Gly Ser Thr Ser Arg Leu Ser Ser Ser Thr Glu
        195                 200                 205             
Gln Ser Thr Ser Ser Arg Leu Ile Arg Lys His Lys Arg Arg Arg Arg
    210                 215                 220                 
Lys Gln Arg Leu Arg Gln Ala Asp Arg Ala Ser Ser Phe Ser Ser Ile
225                 230                 235                 240 
Thr Asp Ser Thr Met Ser Leu Asn Ile Val Thr Val Thr Leu Asn Met
                245                 250                 255     
Glu Arg His His Phe Leu Gly Ile Ser Ile Val Gly Gln Ser Asn Asp
            260                 265                 270         
Arg Gly Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly Gly Ala
        275                 280                 285             
Val Ala Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu Gln Val
    290                 295                 300                 
Asn Asp Val Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val Arg Val
305                 310                 315                 320 
Leu Arg Glu Ile Val Ser Gln Thr Gly Pro Ile Ser Leu Thr Val Ala
                325                 330                 335     
Lys Cys Trp Asp Pro Thr Pro Arg Ser Tyr Phe Thr Val Pro Arg Ala
            340                 345                 350         
Asp Pro Val Arg Pro Ile Asp Pro Ala Ala Trp Leu Ser His Thr Ala
        355                 360                 365             
Ala Leu Thr Gly Ala Leu Pro Arg Tyr Glu Leu Glu Glu Ala Pro Leu
    370                 375                 380                 
Thr Val Lys Ser Asp Met Ser Ala Val Val Arg Val Met Gln Leu Pro
385                 390                 395                 400 
Asp Ser Gly Leu Glu Ile Arg Asp Arg Met Trp Leu Lys Ile Thr Ile
                405                 410                 415     
Ala Asn Ala Val Ile Gly Ala Asp Val Val Asp Trp Leu Tyr Thr His
            420                 425                 430         
Val Glu Gly Phe Lys Glu Arg Arg Glu Ala Arg Lys Tyr Ala Ser Ser
        435                 440                 445             
Leu Leu Lys His Gly Phe Leu Arg His Thr Val Asn Lys Ile Thr Phe
    450                 455                 460                 
Ser Glu Gln Cys Tyr Tyr Val Phe Gly Asp Leu Cys Ser Asn Leu Ala
465                 470                 475                 480 
Thr Leu Asn Leu Asn Ser Gly Ser Ser Gly Thr Ser Asp Gln Asp Thr
                485                 490                 495     
Leu Ala Pro Leu Pro His Pro Ala Ala Pro Trp Pro Leu Gly Gln Gly
            500                 505                 510         
Tyr Pro Tyr Gln Tyr Pro Gly Pro Pro Pro Cys Phe Pro Pro Ala Tyr
        515                 520                 525             
Gln Asp Pro Gly Phe Ser Tyr Gly Ser Gly Ser Thr Gly Ser Gln Gln
    530                 535                 540                 
Ser Glu Gly Ser Lys Ser Ser Gly Ser Thr Arg Ser Ser Arg Arg Ala
545                 550                 555                 560 
Pro Gly Arg Glu Lys Glu Arg Arg Ala Ala Gly Ala Gly Gly Ser Gly
                565                 570                 575     
Ser Glu Ser Asp His Thr Ala Pro Ser Gly Val Gly Ser Ser Trp Arg
            580                 585                 590         
Glu Arg Pro Ala Gly Gln Leu Ser Arg Gly Ser Ser Pro Arg Ser Gln
        595                 600                 605             
Ala Ser Ala Thr Ala Pro Gly Leu Pro Pro Pro His Pro Thr Thr Lys
    610                 615                 620                 
Ala Tyr Thr Val Val Gly Gly Pro Pro Gly Gly Pro Pro Val Arg Glu
625                 630                 635                 640 
Leu Ala Ala Val Pro Pro Glu Leu Thr Gly Ser Arg Gln Ser Phe Gln
                645                 650                 655     
Lys Ala Met Gly Asn Pro Cys Glu Phe Phe Val Asp Ile Met
            660                 665                 670 


<210> 7208
<211> 451
<212> PRT
<213> Homo sapiens

<400> 7208
Met Ala Glu Thr Lys Ile Ile Tyr His Met Asp Glu Glu Glu Thr Pro
 1               5                  10                  15      
Tyr Leu Val Lys Leu Pro Val Ala Pro Glu Arg Val Thr Leu Ala Asp
            20                  25                  30          
Phe Lys Asn Val Leu Ser Asn Arg Pro Val His Ala Tyr Lys Phe Phe
        35                  40                  45              
Phe Lys Ser Met Asp Gln Asp Phe Gly Val Val Lys Glu Glu Ile Phe
    50                  55                  60                  
Asp Asp Asn Ala Lys Leu Pro Cys Phe Asn Gly Arg Val Val Ser Trp
65                  70                  75                  80  
Leu Val Leu Ala Glu Gly Ala His Ser Asp Ala Gly Ser Gln Gly Thr
                85                  90                  95      
Asp Ser His Thr Asp Leu Pro Pro Pro Leu Glu Arg Thr Gly Gly Ile
            100                 105                 110         
Gly Asp Ser Arg Pro Pro Ser Phe His Pro Asn Val Ala Ser Ser Arg
        115                 120                 125             
Asp Gly Met Asp Asn Glu Thr Gly Thr Glu Ser Met Val Ser His Arg
    130                 135                 140                 
Arg Glu Arg Ala Arg Arg Arg Asn Arg Glu Glu Ala Ala Arg Thr Asn
145                 150                 155                 160 
Gly His Pro Arg Gly Asp Arg Arg Arg Asp Val Gly Leu Pro Pro Asp
                165                 170                 175     
Ser Ala Ser Thr Ala Leu Ser Ser Glu Leu Glu Ser Ser Ser Phe Val
            180                 185                 190         
Asp Ser Asp Glu Asp Gly Ser Thr Ser Arg Trp Ala Asp Val Val Asp
        195                 200                 205             
Trp Leu Tyr Thr His Val Glu Gly Phe Lys Glu Arg Arg Glu Ala Arg
    210                 215                 220                 
Lys Tyr Ala Ser Ser Leu Leu Lys His Gly Phe Leu Arg His Thr Val
225                 230                 235                 240 
Asn Lys Ile Thr Phe Ser Glu Gln Cys Tyr Tyr Val Phe Gly Asp Leu
                245                 250                 255     
Cys Ser Asn Leu Ala Thr Leu Asn Leu Asn Ser Gly Ser Ser Gly Thr
            260                 265                 270         
Ser Asp Gln Asp Thr Leu Ala Pro Leu Pro His Pro Ala Ala Pro Trp
        275                 280                 285             
Pro Leu Gly Gln Gly Tyr Pro Tyr Gln Tyr Pro Gly Pro Pro Pro Cys
    290                 295                 300                 
Phe Pro Pro Ala Tyr Gln Asp Pro Gly Phe Ser Tyr Gly Ser Gly Ser
305                 310                 315                 320 
Thr Gly Ser Gln Gln Ser Glu Gly Ser Lys Ser Ser Gly Ser Thr Arg
                325                 330                 335     
Ser Ser Arg Arg Ala Pro Gly Arg Glu Lys Glu Arg Arg Ala Ala Gly
            340                 345                 350         
Ala Gly Gly Ser Gly Ser Glu Ser Asp His Thr Ala Pro Ser Gly Val
        355                 360                 365             
Gly Ser Ser Trp Arg Glu Arg Pro Ala Gly Gln Leu Ser Arg Gly Ser
    370                 375                 380                 
Ser Pro Arg Ser Gln Ala Ser Ala Thr Ala Pro Gly Leu Pro Pro Pro
385                 390                 395                 400 
His Pro Thr Thr Lys Ala Tyr Thr Val Val Gly Gly Pro Pro Gly Gly
                405                 410                 415     
Pro Pro Val Arg Glu Leu Ala Ala Val Pro Pro Glu Leu Thr Gly Ser
            420                 425                 430         
Arg Gln Ser Phe Gln Lys Ala Met Gly Asn Pro Cys Glu Phe Phe Val
        435                 440                 445             
Asp Ile Met
    450     


<210> 7209
<211> 475
<212> PRT
<213> Homo sapiens

<400> 7209
Met Ala Gly Arg Pro His Pro Tyr Asp Gly Asn Ser Ser Asp Pro Glu
 1               5                  10                  15      
Asn Trp Asp Arg Lys Leu His Ser Arg Pro Arg Lys Leu Tyr Lys His
            20                  25                  30          
Ser Ser Thr Ser Ser Arg Ile Ala Lys Gly Gly Val Asp His Thr Lys
        35                  40                  45              
Met Ser Leu His Gly Ala Ser Gly Gly His Glu Arg Ser Arg Asp Arg
    50                  55                  60                  
Arg Arg Ser Ser Asp Arg Ser Arg Asp Ser Ser His Glu Arg Thr Glu
65                  70                  75                  80  
Ser Gln Leu Thr Pro Cys Ile Arg Asn Val Thr Ser Pro Thr Arg Gln
                85                  90                  95      
His His Val Glu Arg Glu Lys Asp His Ser Ser Ser Arg Pro Ser Ser
            100                 105                 110         
Pro Arg Pro Gln Lys Ala Ser Pro Asn Gly Ser Ile Ser Ser Ala Gly
        115                 120                 125             
Asn Ser Ser Arg Asn Ser Ser Gln Ser Ser Ser Asp Gly Ser Cys Lys
    130                 135                 140                 
Thr Ala Gly Glu Met Val Phe Val Tyr Glu Asn Ala Lys Glu Gly Ala
145                 150                 155                 160 
Arg Asn Ile Arg Thr Ser Glu Arg Val Thr Leu Ile Val Asp Asn Thr
                165                 170                 175     
Arg Phe Val Val Asp Pro Ser Ile Phe Thr Ala Gln Pro Asn Thr Met
            180                 185                 190         
Leu Gly Arg Met Phe Gly Ser Gly Arg Glu His Asn Phe Thr Arg Pro
        195                 200                 205             
Asn Glu Lys Gly Glu Tyr Glu Val Ala Glu Gly Ile Gly Ser Thr Val
    210                 215                 220                 
Phe Arg Ala Ile Leu Asp Tyr Tyr Lys Thr Gly Ile Ile Arg Cys Pro
225                 230                 235                 240 
Asp Gly Ile Ser Ile Pro Glu Leu Arg Glu Ala Cys Asp Tyr Leu Cys
                245                 250                 255     
Ile Ser Phe Glu Tyr Ser Thr Ile Lys Cys Arg Asp Leu Ser Ala Leu
            260                 265                 270         
Met His Glu Leu Ser Asn Asp Gly Ala Arg Arg Gln Phe Glu Phe Tyr
        275                 280                 285             
Leu Glu Glu Met Ile Leu Pro Leu Met Val Ala Ser Ala Gln Ser Gly
    290                 295                 300                 
Glu Arg Glu Cys His Ile Val Val Leu Thr Asp Asp Asp Val Val Asp
305                 310                 315                 320 
Trp Asp Glu Glu Tyr Pro Pro Gln Met Gly Glu Glu Tyr Ser Gln Ile
                325                 330                 335     
Ile Tyr Ser Thr Lys Leu Tyr Arg Phe Phe Lys Tyr Ile Glu Asn Arg
            340                 345                 350         
Asp Val Ala Lys Ser Val Leu Lys Glu Arg Gly Leu Lys Lys Ile Arg
        355                 360                 365             
Leu Gly Ile Glu Gly Tyr Pro Thr Tyr Lys Glu Lys Val Lys Lys Arg
    370                 375                 380                 
Pro Gly Gly Arg Pro Glu Val Ile Tyr Asn Tyr Val Gln Arg Pro Phe
385                 390                 395                 400 
Ile Arg Met Ser Trp Glu Lys Glu Glu Gly Lys Ser Arg His Val Asp
                405                 410                 415     
Phe Gln Cys Val Lys Ser Lys Ser Ile Thr Asn Leu Ala Ala Ala Ala
            420                 425                 430         
Ala Asp Ile Pro Gln Asp Gln Leu Val Val Met His Pro Thr Pro Gln
        435                 440                 445             
Val Asp Glu Leu Asp Ile Leu Pro Ile His Pro Pro Ser Gly Asn Ser
    450                 455                 460                 
Asp Leu Asp Pro Asp Ala Gln Asn Pro Met Leu
465                 470                 475 


<210> 7210
<211> 135
<212> PRT
<213> Homo sapiens

<400> 7210
Met Ile Ile Tyr Trp Asp Leu Ile Ser His Ser Glu Met Phe Ser Asp
 1               5                  10                  15      
Ser Tyr Met Ser Gln Glu Ile Ala Asp Gly Leu Arg Leu Glu Val Glu
            20                  25                  30          
Gly Lys Ile Val Ser Arg Thr Glu Gly Asn Ile Phe Asp Ser Leu Ile
        35                  40                  45              
Gly Gly Asn Ala Ser Ala Glu Gly Pro Glu Gly Lys Gly Thr Glu Ser
    50                  55                  60                  
Thr Val Ile Thr Gly Val Asp Ser Val Met Asn His His Leu Gln Glu
65                  70                  75                  80  
Thr Ser Phe Thr Lys Glu Ala Tyr Asn Lys Cys Ile Lys Asp Tyr Met
                85                  90                  95      
Lys Ser Ile Lys Gly Lys Leu Glu Glu Gln Arg Pro Lys Arg Val Lys
            100                 105                 110         
Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala Asn
        115                 120                 125             
Phe Lys Asn Tyr Gln Lys Thr
    130                 135 


<210> 7211
<211> 947
<212> PRT
<213> Homo sapiens

<400> 7211
Met Ala Thr Arg Val Arg Thr Ala Ser Ile Trp Val Pro Pro Leu Gln
 1               5                  10                  15      
Glu Arg Asn Ser Ser Trp Asp Arg Ile Arg Lys Leu Gln Gly Gln Glu
            20                  25                  30          
Ser Ile Leu Gly Gln Gly Thr Pro Gly Leu Gln Pro Leu Pro Gly Thr
        35                  40                  45              
Pro Arg Gln Lys Gln Lys Ser Arg Arg Ile Glu Lys Val Leu Glu Trp
    50                  55                  60                  
Leu Phe Ile Ser Gln Glu Gln Pro Lys Ile Thr Lys Ser Trp Gly Pro
65                  70                  75                  80  
Leu Ser Phe Met Asp Val Phe Val Asp Phe Thr Trp Glu Glu Trp Gln
                85                  90                  95      
Leu Leu Asp Pro Ala Gln Lys Cys Leu Tyr Arg Ser Val Met Leu Glu
            100                 105                 110         
Asn Tyr Ser Asn Leu Val Ser Leu Gly Tyr Gln His Thr Lys Pro Asp
        115                 120                 125             
Ile Ile Phe Lys Leu Glu Gln Gly Glu Glu Leu Cys Met Val Gln Ala
    130                 135                 140                 
Gln Val Pro Asn Gln Thr Cys Pro Asn Thr Val Trp Lys Ile Asp Asp
145                 150                 155                 160 
Leu Met Asp Trp His Gln Glu Asn Lys Asp Lys Leu Gly Ser Thr Ala
                165                 170                 175     
Lys Ser Phe Glu Cys Thr Thr Phe Gly Lys Leu Cys Leu Leu Ser Thr
            180                 185                 190         
Lys Tyr Leu Ser Arg Gln Lys Pro His Lys Cys Gly Thr His Gly Lys
        195                 200                 205             
Ser Leu Lys Tyr Ile Asp Phe Thr Ser Asp Tyr Ala Arg Asn Asn Pro
    210                 215                 220                 
Asn Gly Phe Gln Val His Gly Lys Ser Phe Phe His Ser Lys His Glu
225                 230                 235                 240 
Gln Thr Val Ile Gly Ile Lys Tyr Cys Glu Ser Ile Glu Ser Gly Lys
                245                 250                 255     
Thr Val Asn Lys Lys Ser Gln Leu Met Cys Gln Gln Met Tyr Met Gly
            260                 265                 270         
Glu Lys Pro Phe Gly Cys Ser Cys Cys Glu Lys Ala Phe Ser Ser Lys
        275                 280                 285             
Ser Tyr Leu Leu Val His Gln Gln Thr His Ala Glu Glu Lys Pro Tyr
    290                 295                 300                 
Gly Cys Asn Glu Cys Gly Lys Asp Phe Ser Ser Lys Ser Tyr Leu Ile
305                 310                 315                 320 
Val His Gln Arg Ile His Thr Gly Glu Lys Leu His Glu Cys Ser Glu
                325                 330                 335     
Cys Arg Lys Thr Phe Ser Phe His Ser Gln Leu Val Ile His Gln Arg
            340                 345                 350         
Ile His Thr Gly Glu Asn Pro Tyr Glu Cys Cys Glu Cys Gly Lys Val
        355                 360                 365             
Phe Ser Arg Lys Asp Gln Leu Val Ser His Gln Lys Thr His Ser Gly
    370                 375                 380                 
Gln Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Gly Leu Lys
385                 390                 395                 400 
Ser Gln Leu Ile Ile His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr
                405                 410                 415     
Glu Cys Asn Glu Cys Gln Lys Ala Phe Asn Thr Lys Ser Asn Leu Met
            420                 425                 430         
Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Ser Asp
        435                 440                 445             
Cys Gly Lys Ala Phe Thr Phe Lys Ser Gln Leu Ile Val His Gln Gly
    450                 455                 460                 
Ile His Thr Gly Val Lys Pro Tyr Gly Cys Ile Gln Cys Gly Lys Gly
465                 470                 475                 480 
Phe Ser Leu Lys Ser Gln Leu Ile Val His Gln Arg Ser His Thr Gly
                485                 490                 495     
Met Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Arg Ser Lys
            500                 505                 510         
Ser Tyr Leu Ile Ile His Thr Arg Thr His Thr Gly Glu Lys Leu His
        515                 520                 525             
Glu Cys Asn Asn Cys Gly Lys Ala Phe Ser Phe Lys Ser Gln Leu Ile
    530                 535                 540                 
Ile His Gln Arg Ile His Thr Gly Glu Asn Pro Tyr Glu Cys His Glu
545                 550                 555                 560 
Cys Gly Lys Ala Phe Ser Arg Lys Tyr Gln Leu Ile Ser His Gln Arg
                565                 570                 575     
Thr His Ala Gly Glu Lys Pro Tyr Glu Cys Thr Asp Cys Gly Lys Ala
            580                 585                 590         
Phe Gly Leu Lys Ser Gln Leu Ile Ile His Gln Arg Thr His Thr Gly
        595                 600                 605             
Glu Lys Pro Phe Glu Cys Ser Glu Cys Gln Lys Ala Phe Asn Thr Lys
    610                 615                 620                 
Ser Asn Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr
625                 630                 635                 640 
Ser Cys Asn Glu Cys Gly Lys Ala Phe Thr Phe Lys Ser Gln Leu Ile
                645                 650                 655     
Val His Lys Gly Val His Thr Gly Val Lys Pro Tyr Gly Cys Ser Gln
            660                 665                 670         
Cys Ala Lys Thr Phe Ser Leu Lys Ser Gln Leu Ile Val His Gln Arg
        675                 680                 685             
Ser His Thr Gly Val Lys Pro Tyr Gly Cys Ser Glu Cys Gly Lys Ala
    690                 695                 700                 
Phe Arg Ser Lys Ser Tyr Leu Ile Ile His Met Arg Thr His Thr Gly
705                 710                 715                 720 
Glu Lys Pro His Glu Cys Arg Glu Cys Gly Lys Ser Phe Ser Phe Asn
                725                 730                 735     
Ser Gln Leu Ile Val His Gln Arg Ile His Thr Gly Glu Asn Pro Tyr
            740                 745                 750         
Glu Cys Ser Glu Cys Gly Lys Ala Phe Asn Arg Lys Asp Gln Leu Ile
        755                 760                 765             
Ser His Gln Arg Thr His Ala Gly Glu Lys Pro Tyr Gly Cys Ser Glu
    770                 775                 780                 
Cys Gly Lys Ala Phe Ser Ser Lys Ser Tyr Leu Ile Ile His Met Arg
785                 790                 795                 800 
Thr His Ser Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala
                805                 810                 815     
Phe Ile Trp Lys Ser Leu Leu Ile Val His Glu Arg Thr His Ala Gly
            820                 825                 830         
Val Asn Pro Tyr Lys Cys Ser Gln Cys Glu Lys Ser Phe Ser Gly Lys
        835                 840                 845             
Leu Arg Leu Leu Val His Gln Arg Met His Thr Arg Glu Lys Pro Tyr
    850                 855                 860                 
Glu Cys Ser Glu Cys Gly Lys Ala Phe Ile Arg Asn Ser Gln Leu Ile
865                 870                 875                 880 
Val His Gln Arg Thr His Ser Gly Glu Lys Pro Tyr Gly Cys Asn Glu
                885                 890                 895     
Cys Gly Lys Thr Phe Ser Gln Lys Ser Ile Leu Ser Ala His Gln Arg
            900                 905                 910         
Thr His Thr Gly Glu Lys Pro Cys Lys Cys Thr Glu Cys Gly Lys Ala
        915                 920                 925             
Phe Cys Trp Lys Ser Gln Leu Ile Met His Gln Arg Thr His Val Asp
    930                 935                 940                 
Asp Lys His
945         


<210> 7212
<211> 615
<212> PRT
<213> Homo sapiens

<400> 7212
Met Thr Ser Thr Leu Ile Lys Thr Ser Asp Glu Asp Arg Glu Ser Lys
 1               5                  10                  15      
Phe Gly Phe Val Phe Ala Val Ser Gly Pro Val Val Thr Ala Glu Arg
            20                  25                  30          
Met Ala Gly Ser Ala Met Tyr Glu Leu Val Arg Val Gly Tyr Tyr Glu
        35                  40                  45              
Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Thr Ile Gln
    50                  55                  60                  
Val Tyr Glu Asp Thr Ser Gly Val Thr Val Gly Asp Pro Val Leu Arg
65                  70                  75                  80  
Thr Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly Ser
                85                  90                  95      
Ile Phe Asp Gly Ile Gln Arg Pro Leu Lys Asp Ile Asn Glu Leu Ser
            100                 105                 110         
Asn Ser Ile Tyr Ile Pro Lys Gly Val Asn Val Pro Ala Leu Ser Arg
        115                 120                 125             
Thr Ala Gln Trp Asp Phe Ser Pro Val Ser Val Lys Val Gly Ser His
    130                 135                 140                 
Ile Thr Gly Gly Asp Leu Tyr Gly Leu Val His Glu Asn Thr Leu Val
145                 150                 155                 160 
Lys His Lys Leu Leu Leu Pro Pro Arg Ala Lys Gly Thr Val Thr Tyr
                165                 170                 175     
Ile Ala Glu Pro Gly Asn Tyr Thr Val Asp Asp Val Val Leu Glu Thr
            180                 185                 190         
Glu Phe Asp Gly Glu Arg Ser Lys Phe Thr Met Leu Gln Val Trp Pro
        195                 200                 205             
Val Arg Gln Pro Arg Pro Val Thr Glu Lys Leu Pro Ala Asn Tyr Pro
    210                 215                 220                 
Leu Leu Thr Gly Gln Arg Val Leu Asp Ser Leu Phe Pro Cys Val Gln
225                 230                 235                 240 
Gly Gly Thr Thr Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys Thr Val
                245                 250                 255     
Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile Ile Tyr
            260                 265                 270         
Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu Arg Asp
        275                 280                 285             
Phe Pro Gln Leu Ser Leu Glu Ile Asp Gly Val Thr Glu Ser Ile Met
    290                 295                 300                 
Lys Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val Ala Ala
305                 310                 315                 320 
Arg Glu Ala Ser Ile Tyr Thr Gly Ile Thr Leu Ser Glu Tyr Phe Arg
                325                 330                 335     
Asp Met Gly Tyr Asn Val Ser Met Met Ala Asp Ser Thr Ser Arg Trp
            340                 345                 350         
Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met Pro Ala
        355                 360                 365             
Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser Phe Tyr
    370                 375                 380                 
Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Asp Arg Glu Gly
385                 390                 395                 400 
Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp Phe Ser
                405                 410                 415     
Asp Pro Val Thr Thr Ala Thr Leu Gly Ile Val Gln Val Phe Trp Gly
            420                 425                 430         
Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Ile Asn Trp
        435                 440                 445             
Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Asp Phe Tyr Asp
    450                 455                 460                 
Lys Asn Phe Pro Glu Phe Val Pro Leu Arg Thr Lys Val Lys Glu Ile
465                 470                 475                 480 
Leu Gln Glu Glu Glu Asp Leu Ser Glu Ile Val Gln Leu Val Gly Lys
                485                 490                 495     
Ala Ser Leu Ala Glu Thr Asp Lys Ile Thr Leu Glu Val Ala Lys Leu
            500                 505                 510         
Leu Lys Asp Asp Phe Leu Gln Gln Asn Ser Tyr Ser Pro Tyr Asp Arg
        515                 520                 525             
Phe Cys Pro Phe Tyr Lys Thr Val Gly Met Leu Lys Asn Met Ile Ala
    530                 535                 540                 
Phe Tyr Asp Met Ser Arg His Ala Val Glu Ser Thr Ala Gln Ser Glu
545                 550                 555                 560 
Asn Lys Ile Thr Trp Asn Val Ile Arg Asp Ser Met Gly Asn Ile Leu
                565                 570                 575     
Tyr Gln Leu Ser Ser Met Lys Phe Lys Asp Pro Val Lys Asp Gly Glu
            580                 585                 590         
Ala Lys Ile Lys Ala Asp Phe Glu Gln Leu His Glu Asp Ile Gln Gln
        595                 600                 605             
Ala Phe Arg Asn Leu Glu Asp
    610                 615 


<210> 7213
<211> 617
<212> PRT
<213> Homo sapiens

<400> 7213
Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser
 1               5                  10                  15      
Thr Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Thr Ala Cys
            20                  25                  30          
Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser
        35                  40                  45              
Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Thr Ile
    50                  55                  60                  
Gln Val Tyr Glu Glu Thr Ser Gly Val Ser Val Gly Asp Pro Val Leu
65                  70                  75                  80  
Arg Thr Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly
                85                  90                  95      
Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln
            100                 105                 110         
Thr Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser
        115                 120                 125             
Arg Asp Ile Lys Trp Asp Phe Thr Pro Cys Lys Asn Leu Arg Val Gly
    130                 135                 140                 
Ser His Ile Thr Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser
145                 150                 155                 160 
Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Thr Val
                165                 170                 175     
Thr Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Thr Ser Asp Val Val Leu
            180                 185                 190         
Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Thr Met Val Gln Val
        195                 200                 205             
Trp Pro Val Arg Gln Val Arg Pro Val Thr Glu Lys Leu Pro Ala Asn
    210                 215                 220                 
His Pro Leu Leu Thr Gly Gln Arg Val Leu Asp Ala Leu Phe Pro Cys
225                 230                 235                 240 
Val Gln Gly Gly Thr Thr Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys
                245                 250                 255     
Thr Val Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile
            260                 265                 270         
Ile Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu
        275                 280                 285             
Arg Asp Phe Pro Glu Leu Thr Met Glu Val Asp Gly Lys Val Glu Ser
    290                 295                 300                 
Ile Met Lys Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val
305                 310                 315                 320 
Ala Ala Arg Glu Ala Ser Ile Tyr Thr Gly Ile Thr Leu Ser Glu Tyr
                325                 330                 335     
Phe Arg Asp Met Gly Tyr His Val Ser Met Met Ala Asp Ser Thr Ser
            340                 345                 350         
Arg Trp Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met
        355                 360                 365             
Pro Ala Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser
    370                 375                 380                 
Phe Tyr Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Glu Arg
385                 390                 395                 400 
Glu Gly Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp
                405                 410                 415     
Phe Ser Asp Pro Val Thr Ser Ala Thr Leu Gly Ile Val Gln Val Phe
            420                 425                 430         
Trp Gly Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Val
        435                 440                 445             
Asn Trp Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Glu Tyr
    450                 455                 460                 
Tyr Asp Lys His Phe Thr Glu Phe Val Pro Leu Arg Thr Lys Ala Lys
465                 470                 475                 480 
Glu Ile Leu Gln Glu Glu Glu Asp Leu Ala Glu Ile Val Gln Leu Val
                485                 490                 495     
Gly Lys Ala Ser Leu Ala Glu Thr Asp Lys Ile Thr Leu Glu Val Ala
            500                 505                 510         
Lys Leu Ile Lys Asp Asp Phe Leu Gln Gln Asn Gly Tyr Thr Pro Tyr
        515                 520                 525             
Asp Arg Phe Cys Pro Phe Tyr Lys Thr Val Gly Met Leu Ser Asn Met
    530                 535                 540                 
Ile Ala Phe Tyr Asp Met Ala Arg Arg Ala Val Glu Thr Thr Ala Gln
545                 550                 555                 560 
Ser Asp Asn Lys Ile Thr Trp Ser Ile Ile Arg Glu His Met Gly Asp
                565                 570                 575     
Ile Leu Tyr Lys Leu Ser Ser Met Lys Phe Lys Asp Pro Leu Lys Asp
            580                 585                 590         
Gly Glu Ala Lys Ile Lys Ser Asp Tyr Ala Gln Leu Leu Glu Asp Met
        595                 600                 605             
Gln Asn Ala Phe Arg Ser Leu Glu Asp
    610                 615         


<210> 7214
<211> 1431
<212> PRT
<213> Homo sapiens

<400> 7214
Met Leu Leu Pro Ser Asp Val Ala Arg Leu Val Leu Gly Tyr Leu Gln
 1               5                  10                  15      
Gln Glu Asn Leu Ile Ser Thr Cys Gln Thr Phe Ile Leu Glu Ser Ser
            20                  25                  30          
Asp Leu Lys Glu Tyr Ala Glu His Cys Thr Asp Glu Gly Phe Ile Pro
        35                  40                  45              
Ala Cys Leu Leu Ser Leu Phe Gly Lys Asn Leu Thr Thr Ile Leu Asn
    50                  55                  60                  
Glu Tyr Val Ala Met Lys Thr Lys Glu Thr Ser Asn Asn Val Pro Ala
65                  70                  75                  80  
Ile Met Ser Ser Leu Trp Lys Lys Leu Asp His Thr Leu Ser Gln Ile
                85                  90                  95      
Arg Ser Met Gln Ser Ser Pro Arg Phe Ala Gly Ser Gln Arg Ala Arg
            100                 105                 110         
Thr Arg Thr Gly Ile Ala Glu Ile Lys Arg Gln Arg Lys Leu Ala Ser
        115                 120                 125             
Gln Thr Ala Pro Ala Ser Ala Glu Leu Leu Thr Leu Pro Tyr Leu Ser
    130                 135                 140                 
Gly Gln Phe Thr Thr Pro Pro Ser Thr Gly Thr Gln Val Thr Arg Pro
145                 150                 155                 160 
Ser Gly Gln Ile Ser Asp Pro Ser Arg Ser Tyr Phe Val Val Val Asn
                165                 170                 175     
His Ser Gln Ser Gln Asp Thr Val Thr Thr Gly Glu Ala Leu Asn Val
            180                 185                 190         
Ile Pro Gly Ala Gln Glu Lys Lys Ala His Ala Ser Leu Met Ser Pro
        195                 200                 205             
Gly Arg Arg Lys Ser Glu Ser Gln Arg Lys Ser Thr Thr Leu Ser Gly
    210                 215                 220                 
Pro His Ser Thr Ile Arg Asn Phe Gln Asp Pro Asn Ala Phe Ala Val
225                 230                 235                 240 
Glu Lys Gln Met Val Ile Glu Asn Ala Arg Glu Lys Ile Leu Ser Asn
                245                 250                 255     
Lys Ser Leu Gln Glu Lys Leu Ala Glu Asn Ile Asn Lys Phe Leu Thr
            260                 265                 270         
Ser Asp Asn Asn Ile Ala Gln Val Pro Lys Gln Thr Asp Asn Asn Pro
        275                 280                 285             
Thr Glu Pro Glu Thr Ser Ile Asp Glu Phe Leu Gly Leu Pro Ser Glu
    290                 295                 300                 
Ile His Met Ser Glu Glu Ala Ile Gln Asp Ile Leu Glu Gln Thr Glu
305                 310                 315                 320 
Ser Asp Pro Ala Phe Gln Ala Leu Phe Asp Leu Phe Asp Tyr Gly Lys
                325                 330                 335     
Thr Lys Asn Asn Lys Asn Ile Ser Gln Ser Ile Ser Ser Gln Pro Met
            340                 345                 350         
Glu Ser Asn Pro Ser Ile Val Leu Ala Asp Glu Thr Asn Leu Ala Val
        355                 360                 365             
Lys Gly Ser Phe Glu Thr Glu Glu Ser Asp Gly Gln Ser Gly Gln Pro
    370                 375                 380                 
Ala Phe Cys Thr Ser Tyr Gln Asn Asp Asp Pro Leu Asn Ala Leu Lys
385                 390                 395                 400 
Asn Ser Asn Asn His Asp Val Leu Arg Gln Glu Asp Gln Glu Asn Phe
                405                 410                 415     
Ser Gln Ile Ser Thr Ser Ile Gln Lys Lys Ala Phe Lys Thr Ala Val
            420                 425                 430         
Pro Thr Glu Gln Lys Cys Asp Ile Asp Ile Thr Phe Glu Ser Val Pro
        435                 440                 445             
Asn Leu Asn Asp Phe Asn Gln Arg Gly Asn Ser Asn Ala Glu Cys Asn
    450                 455                 460                 
Pro His Cys Ala Glu Leu Tyr Thr Asn Gln Met Ser Thr Glu Thr Glu
465                 470                 475                 480 
Met Ala Ile Gly Ile Glu Lys Asn Ser Leu Ser Ser Asn Val Pro Ser
                485                 490                 495     
Glu Ser Gln Leu Gln Pro Asp Gln Pro Asp Ile Pro Ile Thr Ser Phe
            500                 505                 510         
Val Ser Leu Gly Cys Glu Ala Asn Asn Glu Asn Leu Ile Leu Ser Gly
        515                 520                 525             
Lys Ser Ser Gln Leu Leu Ser Gln Asp Thr Ser Leu Thr Gly Lys Pro
    530                 535                 540                 
Ser Lys Lys Ser Gln Phe Cys Glu Asn Ser Asn Asp Thr Val Lys Leu
545                 550                 555                 560 
Lys Ile Asn Phe His Gly Ser Lys Ser Ser Asp Ser Ser Glu Val His
                565                 570                 575     
Lys Ser Lys Ile Glu Ile Asn Val Leu Glu Pro Val Met Ser Gln Leu
            580                 585                 590         
Ser Asn Cys Gln Asp Asn Ser Cys Leu Gln Ser Glu Ile Leu Pro Val
        595                 600                 605             
Ser Val Glu Ser Ser His Leu Asn Val Ser Gly Gln Val Glu Ile His
    610                 615                 620                 
Leu Gly Asp Ser Leu Ser Ser Thr Lys Gln Pro Ser Asn Asp Ser Ala
625                 630                 635                 640 
Ser Val Glu Leu Asn His Thr Glu Asn Glu Ala Gln Ala Ser Lys Ser
                645                 650                 655     
Glu Asn Ser Gln Glu Pro Ser Ser Ser Val Lys Glu Glu Asn Thr Ile
            660                 665                 670         
Phe Leu Ser Leu Gly Gly Asn Ala Asn Cys Glu Lys Val Ala Leu Thr
        675                 680                 685             
Pro Pro Glu Gly Thr Pro Val Glu Asn Ser His Ser Leu Pro Pro Glu
    690                 695                 700                 
Ser Val Cys Ser Ser Val Gly Asp Ser His Pro Glu Ser Gln Asn Thr
705                 710                 715                 720 
Asp Asp Lys Pro Ser Ser Asn Asn Ser Ala Glu Ile Asp Ala Ser Asn
                725                 730                 735     
Ile Val Ser Leu Lys Val Ile Ile Ser Asp Asp Pro Phe Val Ser Ser
            740                 745                 750         
Asp Thr Glu Leu Thr Ser Ala Val Ser Ser Ile Asn Gly Glu Asn Leu
        755                 760                 765             
Pro Thr Ile Ile Leu Ser Ser Pro Thr Lys Ser Pro Thr Lys Asn Ala
    770                 775                 780                 
Glu Leu Val Lys Cys Leu Ser Ser Glu Glu Thr Val Gly Ala Val Val
785                 790                 795                 800 
Tyr Ala Glu Val Gly Asp Ser Ala Ser Met Glu Gln Ser Leu Leu Thr
                805                 810                 815     
Phe Lys Ser Glu Asp Ser Ala Val Asn Asn Thr Gln Asn Glu Asp Gly
            820                 825                 830         
Ile Ala Phe Ser Ala Asn Val Thr Pro Cys Val Ser Lys Asp Gly Gly
        835                 840                 845             
Tyr Ile Gln Leu Met Pro Ala Thr Ser Thr Ala Phe Gly Asn Ser Asn
    850                 855                 860                 
Asn Ile Leu Ile Ala Thr Cys Val Thr Asp Pro Thr Ala Leu Gly Thr
865                 870                 875                 880 
Ser Val Ser Gln Ser Asn Val Val Val Leu Pro Gly Asn Ser Ala Pro
                885                 890                 895     
Met Thr Ala Gln Pro Leu Pro Pro Gln Leu Gln Thr Pro Pro Arg Ser
            900                 905                 910         
Asn Ser Val Phe Ala Val Asn Gln Ala Val Ser Pro Asn Phe Ser Gln
        915                 920                 925             
Gly Ser Ala Ile Ile Ile Ala Ser Pro Val Gln Pro Val Leu Gln Gly
    930                 935                 940                 
Met Val Gly Met Ile Pro Val Ser Val Val Gly Gln Asn Gly Asn Asn
945                 950                 955                 960 
Phe Ser Thr Pro Pro Arg Gln Val Leu His Met Pro Leu Thr Ala Pro
                965                 970                 975     
Val Cys Asn Arg Ser Ile Pro Gln Phe Pro Val Pro Pro Lys Ser Gln
            980                 985                 990         
Lys Ala Gln Gly Leu Arg Asn Lys Pro Cys Ile Gly Lys Gln Val Asn
        995                 1000                1005            
Asn Leu Val Asp Ser Ser Gly His Ser Val Gly Cys His Ala Gln Lys
    1010                1015                1020                
Thr Glu Val Ser Asp Lys Ser Ile Ala Thr Asp Leu Gly Lys Lys Ser
1025                1030                1035                1040
Glu Glu Thr Thr Val Pro Phe Pro Glu Glu Ser Ile Val Pro Ala Ala
                1045                1050                1055    
Lys Pro Cys His Arg Arg Val Leu Cys Phe Asp Ser Thr Thr Ala Pro
            1060                1065                1070        
Val Ala Asn Thr Gln Gly Pro Asn His Lys Met Val Ser Gln Asn Lys
        1075                1080                1085            
Glu Arg Asn Ala Val Ser Phe Pro Asn Leu Asp Ser Pro Asn Val Ser
    1090                1095                1100                
Ser Thr Leu Lys Pro Pro Ser Asn Asn Ala Ile Lys Arg Glu Lys Glu
1105                1110                1115                1120
Lys Pro Pro Leu Pro Lys Ile Leu Ser Lys Ser Glu Ser Ala Ile Ser
                1125                1130                1135    
Arg His Thr Thr Ile Arg Glu Thr Gln Ser Glu Lys Lys Val Ser Pro
            1140                1145                1150        
Thr Glu Ile Val Leu Glu Ser Phe His Lys Ala Thr Ala Asn Lys Glu
        1155                1160                1165            
Asn Glu Leu Cys Ser Asp Val Glu Arg Gln Lys Asn Pro Glu Asn Ser
    1170                1175                1180                
Lys Leu Ser Ile Gly Gln Gln Asn Gly Gly Leu Arg Ser Glu Lys Ser
1185                1190                1195                1200
Ile Ala Ser Leu Gln Glu Met Thr Lys Lys Gln Gly Thr Ser Ser Asn
                1205                1210                1215    
Asn Lys Asn Val Leu Ser Val Gly Thr Ala Val Lys Asp Leu Lys Gln
            1220                1225                1230        
Glu Gln Thr Lys Ser Ala Ser Ser Leu Ile Thr Thr Glu Met Leu Gln
        1235                1240                1245            
Asp Ile Gln Arg His Ser Ser Val Ser Arg Leu Ala Asp Ser Ser Asp
    1250                1255                1260                
Leu Pro Val Pro Arg Thr Pro Gly Ser Gly Ala Gly Glu Lys His Lys
1265                1270                1275                1280
Glu Glu Pro Ile Asp Ile Ile Lys Ala Pro Ser Ser Arg Arg Phe Ser
                1285                1290                1295    
Glu Asp Ser Ser Thr Ser Lys Val Met Val Pro Pro Val Thr Pro Asp
            1300                1305                1310        
Leu Pro Ala Cys Ser Pro Ala Ser Glu Thr Gly Ser Glu Asn Ser Val
        1315                1320                1325            
Asn Met Ala Ala His Thr Leu Met Ile Leu Ser Arg Ala Ala Ile Ser
    1330                1335                1340                
Arg Thr Thr Ser Ala Thr Pro Leu Lys Asp Asn Thr Gln Gln Phe Arg
1345                1350                1355                1360
Ala Ser Ser Arg Ser Thr Thr Lys Lys Arg Lys Ile Glu Glu Leu Asp
                1365                1370                1375    
Glu Arg Glu Arg Asn Ser Arg Pro Ser Ser Lys Asn Leu Thr Asn Ser
            1380                1385                1390        
Ser Ile Pro Met Lys Lys Lys Lys Ile Lys Ala Ser Leu Lys Lys Lys
        1395                1400                1405            
Lys Leu Pro Ser Ser Phe Pro Ala Gly Met Asp Val Asp Lys Phe Leu
    1410                1415                1420                
Leu Ser Leu His Tyr Asp Glu
1425                1430    


<210> 7215
<211> 596
<212> PRT
<213> Homo sapiens

<400> 7215
Met Thr Ser Pro Ser Pro Arg Ile Gln Ile Ile Ser Thr Asp Ser Ala
 1               5                  10                  15      
Val Ala Ser Pro Gln Arg Ile Gln Ile Val Thr Asp Gln Gln Thr Gly
            20                  25                  30          
Gln Lys Ile Gln Ile Val Thr Ala Val Asp Ala Ser Gly Ser Pro Lys
        35                  40                  45              
Gln Gln Phe Ile Leu Thr Ser Pro Asp Gly Ala Gly Thr Gly Lys Val
    50                  55                  60                  
Ile Leu Ala Ser Pro Glu Thr Ser Ser Ala Lys Gln Leu Ile Phe Thr
65                  70                  75                  80  
Thr Ser Asp Asn Leu Val Pro Gly Arg Ile Gln Ile Val Thr Asp Ser
                85                  90                  95      
Ala Ser Val Glu Arg Leu Leu Gly Lys Thr Asp Val Gln Arg Pro Gln
            100                 105                 110         
Val Val Glu Tyr Cys Val Val Cys Gly Asp Lys Ala Ser Gly Arg His
        115                 120                 125             
Tyr Gly Ala Val Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Ser
    130                 135                 140                 
Val Arg Lys Asn Leu Thr Tyr Ser Cys Arg Ser Asn Gln Asp Cys Ile
145                 150                 155                 160 
Ile Asn Lys His His Arg Asn Arg Cys Gln Phe Cys Arg Leu Lys Lys
                165                 170                 175     
Cys Leu Glu Met Gly Met Lys Met Glu Ser Val Gln Ser Glu Arg Lys
            180                 185                 190         
Pro Phe Asp Val Gln Arg Glu Lys Pro Ser Asn Cys Ala Ala Ser Thr
        195                 200                 205             
Glu Lys Ile Tyr Ile Arg Lys Asp Leu Arg Ser Pro Leu Ile Ala Thr
    210                 215                 220                 
Pro Thr Phe Val Ala Asp Lys Asp Gly Ala Arg Gln Thr Gly Leu Leu
225                 230                 235                 240 
Asp Pro Gly Met Leu Val Asn Ile Gln Gln Pro Leu Ile Arg Glu Asp
                245                 250                 255     
Gly Thr Val Leu Leu Ala Thr Asp Ser Lys Ala Glu Thr Ser Gln Gly
            260                 265                 270         
Ala Leu Gly Thr Leu Ala Asn Val Val Thr Ser Leu Ala Asn Leu Ser
        275                 280                 285             
Glu Ser Leu Asn Asn Gly Asp Thr Ser Glu Ile Gln Pro Glu Asp Gln
    290                 295                 300                 
Ser Ala Ser Glu Ile Thr Arg Ala Phe Asp Thr Leu Ala Lys Ala Leu
305                 310                 315                 320 
Asn Thr Thr Asp Ser Ser Ser Ser Pro Ser Leu Ala Asp Gly Ile Asp
                325                 330                 335     
Thr Ser Gly Gly Gly Ser Ile His Val Ile Ser Arg Asp Gln Ser Thr
            340                 345                 350         
Pro Ile Ile Glu Val Glu Gly Pro Leu Leu Ser Asp Thr His Val Thr
        355                 360                 365             
Phe Lys Leu Thr Met Pro Ser Pro Met Pro Glu Tyr Leu Asn Val His
    370                 375                 380                 
Tyr Ile Cys Glu Ser Ala Ser Arg Leu Leu Phe Leu Ser Met His Trp
385                 390                 395                 400 
Ala Arg Ser Ile Pro Ala Phe Gln Ala Leu Gly Gln Asp Cys Asn Thr
                405                 410                 415     
Ser Leu Val Arg Ala Cys Trp Asn Glu Leu Phe Thr Leu Gly Leu Ala
            420                 425                 430         
Gln Cys Ala Gln Val Met Ser Leu Ser Thr Ile Leu Ala Ala Ile Val
        435                 440                 445             
Asn His Leu Gln Asn Ser Ile Gln Glu Asp Lys Leu Ser Gly Asp Arg
    450                 455                 460                 
Ile Lys Gln Val Met Glu His Ile Trp Lys Leu Gln Glu Phe Cys Asn
465                 470                 475                 480 
Ser Met Ala Lys Leu Asp Ile Asp Gly Tyr Glu Tyr Ala Tyr Leu Lys
                485                 490                 495     
Ala Ile Val Leu Phe Ser Pro Asp His Pro Gly Leu Thr Ser Thr Ser
            500                 505                 510         
Gln Ile Glu Lys Phe Gln Glu Lys Ala Gln Met Glu Leu Gln Asp Tyr
        515                 520                 525             
Val Gln Lys Thr Tyr Ser Glu Asp Thr Tyr Arg Leu Ala Arg Ile Leu
    530                 535                 540                 
Val Arg Leu Pro Ala Leu Arg Leu Met Ser Ser Asn Ile Thr Glu Glu
545                 550                 555                 560 
Leu Phe Phe Thr Gly Leu Ile Gly Asn Val Ser Ile Asp Ser Ile Ile
                565                 570                 575     
Pro Tyr Ile Leu Lys Met Glu Thr Ala Glu Tyr Asn Gly Gln Ile Thr
            580                 585                 590         
Gly Ala Ser Leu
        595     


<210> 7216
<211> 615
<212> PRT
<213> Homo sapiens

<400> 7216
Met Thr Ser Pro Ser Pro Arg Ile Gln Ile Ile Ser Thr Asp Ser Ala
 1               5                  10                  15      
Val Ala Ser Pro Gln Arg Ile Gln Gly Ser Glu Pro Ala Ser Gly Pro
            20                  25                  30          
Leu Ser Val Phe Thr Ser Leu Asn Lys Glu Lys Ile Val Thr Asp Gln
        35                  40                  45              
Gln Thr Gly Gln Lys Ile Gln Ile Val Thr Ala Val Asp Ala Ser Gly
    50                  55                  60                  
Ser Pro Lys Gln Gln Phe Ile Leu Thr Ser Pro Asp Gly Ala Gly Thr
65                  70                  75                  80  
Gly Lys Val Ile Leu Ala Ser Pro Glu Thr Ser Ser Ala Lys Gln Leu
                85                  90                  95      
Ile Phe Thr Thr Ser Asp Asn Leu Val Pro Gly Arg Ile Gln Ile Val
            100                 105                 110         
Thr Asp Ser Ala Ser Val Glu Arg Leu Leu Gly Lys Thr Asp Val Gln
        115                 120                 125             
Arg Pro Gln Val Val Glu Tyr Cys Val Val Cys Gly Asp Lys Ala Ser
    130                 135                 140                 
Gly Arg His Tyr Gly Ala Val Ser Cys Glu Gly Cys Lys Gly Phe Phe
145                 150                 155                 160 
Lys Arg Ser Val Arg Lys Asn Leu Thr Tyr Ser Cys Arg Ser Asn Gln
                165                 170                 175     
Asp Cys Ile Ile Asn Lys His His Arg Asn Arg Cys Gln Phe Cys Arg
            180                 185                 190         
Leu Lys Lys Cys Leu Glu Met Gly Met Lys Met Glu Ser Val Gln Ser
        195                 200                 205             
Glu Arg Lys Pro Phe Asp Val Gln Arg Glu Lys Pro Ser Asn Cys Ala
    210                 215                 220                 
Ala Ser Thr Glu Lys Ile Tyr Ile Arg Lys Asp Leu Arg Ser Pro Leu
225                 230                 235                 240 
Ile Ala Thr Pro Thr Phe Val Ala Asp Lys Asp Gly Ala Arg Gln Thr
                245                 250                 255     
Gly Leu Leu Asp Pro Gly Met Leu Val Asn Ile Gln Gln Pro Leu Ile
            260                 265                 270         
Arg Glu Asp Gly Thr Val Leu Leu Ala Thr Asp Ser Lys Ala Glu Thr
        275                 280                 285             
Ser Gln Gly Ala Leu Gly Thr Leu Ala Asn Val Val Thr Ser Leu Ala
    290                 295                 300                 
Asn Leu Ser Glu Ser Leu Asn Asn Gly Asp Thr Ser Glu Ile Gln Pro
305                 310                 315                 320 
Glu Asp Gln Ser Ala Ser Glu Ile Thr Arg Ala Phe Asp Thr Leu Ala
                325                 330                 335     
Lys Ala Leu Asn Thr Thr Asp Ser Ser Ser Ser Pro Ser Leu Ala Asp
            340                 345                 350         
Gly Ile Asp Thr Ser Gly Gly Gly Ser Ile His Val Ile Ser Arg Asp
        355                 360                 365             
Gln Ser Thr Pro Ile Ile Glu Val Glu Gly Pro Leu Leu Ser Asp Thr
    370                 375                 380                 
His Val Thr Phe Lys Leu Thr Met Pro Ser Pro Met Pro Glu Tyr Leu
385                 390                 395                 400 
Asn Val His Tyr Ile Cys Glu Ser Ala Ser Arg Leu Leu Phe Leu Ser
                405                 410                 415     
Met His Trp Ala Arg Ser Ile Pro Ala Phe Gln Ala Leu Gly Gln Asp
            420                 425                 430         
Cys Asn Thr Ser Leu Val Arg Ala Cys Trp Asn Glu Leu Phe Thr Leu
        435                 440                 445             
Gly Leu Ala Gln Cys Ala Gln Val Met Ser Leu Ser Thr Ile Leu Ala
    450                 455                 460                 
Ala Ile Val Asn His Leu Gln Asn Ser Ile Gln Glu Asp Lys Leu Ser
465                 470                 475                 480 
Gly Asp Arg Ile Lys Gln Val Met Glu His Ile Trp Lys Leu Gln Glu
                485                 490                 495     
Phe Cys Asn Ser Met Ala Lys Leu Asp Ile Asp Gly Tyr Glu Tyr Ala
            500                 505                 510         
Tyr Leu Lys Ala Ile Val Leu Phe Ser Pro Asp His Pro Gly Leu Thr
        515                 520                 525             
Ser Thr Ser Gln Ile Glu Lys Phe Gln Glu Lys Ala Gln Met Glu Leu
    530                 535                 540                 
Gln Asp Tyr Val Gln Lys Thr Tyr Ser Glu Asp Thr Tyr Arg Leu Ala
545                 550                 555                 560 
Arg Ile Leu Val Arg Leu Pro Ala Leu Arg Leu Met Ser Ser Asn Ile
                565                 570                 575     
Thr Glu Glu Leu Phe Phe Thr Gly Leu Ile Gly Asn Val Ser Ile Asp
            580                 585                 590         
Ser Ile Ile Pro Tyr Ile Leu Lys Met Glu Thr Ala Glu Tyr Asn Gly
        595                 600                 605             
Gln Ile Thr Gly Ala Ser Leu
    610                 615 


<210> 7217
<211> 1288
<212> PRT
<213> Homo sapiens

<400> 7217
Met Glu Pro Ile Tyr Pro Phe Ala Arg Pro Gln Met Asn Thr Arg Phe
 1               5                  10                  15      
Pro Ser Ser Arg Met Val Pro Phe His Phe Pro Pro Ser Lys Cys Ala
            20                  25                  30          
Leu Trp Asn Pro Thr Pro Thr Gly Asp Phe Ile Tyr Leu His Leu Ser
        35                  40                  45              
Tyr Tyr Arg Asn Pro Lys Leu Val Val Thr Glu Lys Thr Ile Arg Leu
    50                  55                  60                  
Ala Tyr Arg His Ala Lys Gln Asn Lys Lys Asn Ser Ser Cys Phe Leu
65                  70                  75                  80  
Leu Gly Ser Leu Thr Ala Asp Glu Asp Glu Glu Gly Val Thr Leu Thr
                85                  90                  95      
Val Asp Arg Phe Asp Pro Gly Arg Glu Val Pro Glu Cys Leu Glu Ile
            100                 105                 110         
Thr Pro Thr Ala Ser Leu Pro Gly Asp Phe Leu Ile Pro Cys Lys Val
        115                 120                 125             
His Thr Gln Glu Leu Cys Ser Arg Glu Met Ile Val His Ser Val Asp
    130                 135                 140                 
Asp Phe Ser Ser Ala Leu Lys Ala Leu Gln Cys His Ile Cys Ser Lys
145                 150                 155                 160 
Asp Ser Leu Asp Cys Gly Lys Leu Leu Ser Leu Arg Val His Ile Thr
                165                 170                 175     
Ser Arg Glu Ser Leu Asp Ser Val Glu Phe Asp Leu His Trp Ala Ala
            180                 185                 190         
Val Thr Leu Ala Asn Asn Phe Lys Cys Thr Pro Val Lys Pro Ile Pro
        195                 200                 205             
Ile Ile Pro Thr Ala Leu Ala Arg Asn Leu Ser Ser Asn Leu Asn Ile
    210                 215                 220                 
Ser Gln Val Gln Gly Thr Tyr Lys Tyr Gly Tyr Leu Thr Met Asp Glu
225                 230                 235                 240 
Thr Arg Lys Leu Leu Leu Leu Leu Glu Ser Asp Pro Lys Val Tyr Ser
                245                 250                 255     
Leu Pro Leu Val Gly Ile Trp Leu Ser Gly Ile Thr His Ile Tyr Ser
            260                 265                 270         
Pro Gln Val Trp Ala Cys Cys Leu Arg Tyr Ile Phe Asn Ser Ser Val
        275                 280                 285             
Gln Glu Arg Gln Val Phe Ser Glu Ser Gly Asn Phe Ile Ile Val Leu
    290                 295                 300                 
Tyr Ser Met Thr His Lys Glu Pro Glu Phe Tyr Glu Cys Phe Pro Cys
305                 310                 315                 320 
Asp Gly Lys Ile Pro Asp Phe Arg Phe Gln Leu Leu Thr Ser Lys Glu
                325                 330                 335     
Thr Leu His Leu Phe Lys Asn Val Glu Pro Pro Asp Lys Asn Pro Ile
            340                 345                 350         
Arg Cys Glu Leu Ser Ala Glu Ser Gln Asn Ala Glu Thr Glu Phe Phe
        355                 360                 365             
Ser Lys Ala Ser Lys Asn Phe Ser Ile Lys Arg Ser Ser Gln Lys Leu
    370                 375                 380                 
Ser Ser Gly Lys Met Pro Ile His Asp His Asp Ser Gly Val Glu Asp
385                 390                 395                 400 
Glu Asp Phe Ser Pro Arg Pro Ile Pro Ser Pro His Pro Val Ser Gln
                405                 410                 415     
Lys Ile Ser Lys Ile Gln Pro Ser Val Pro Glu Leu Ser Leu Val Leu
            420                 425                 430         
Asp Gly Asn Phe Ile Glu Ser Asn Pro Leu Pro Thr Pro Leu Glu Met
        435                 440                 445             
Val Asn Asn Glu Asn Pro Pro Leu Ile Asn His Leu Glu His Leu Lys
    450                 455                 460                 
Pro Leu Gln Pro Gln Leu Tyr Asp Glu Lys His Ser Pro Glu Val Glu
465                 470                 475                 480 
Ala Gly Glu Pro Ser Leu Arg Gly Ile Pro Asn Gln Leu Asn Gln Asp
                485                 490                 495     
Lys Pro Ala Leu Leu Arg His Cys Lys Val Arg Gln Pro Pro Ala Tyr
            500                 505                 510         
Lys Lys Gly Asn Pro His Thr Arg Asn Ser Ile Lys Pro Ser Ser His
        515                 520                 525             
Asn Gly Pro Ser His Asp Ile Phe Glu Lys Leu Gln Thr Val Ser Ala
    530                 535                 540                 
Gly Asn Val Gln Asn Glu Glu Tyr Pro Ile Arg Pro Ser Thr Leu Asn
545                 550                 555                 560 
Ser Arg Gln Ser Ser Leu Ala Pro Gln Ser Gln Pro His Asp Phe Val
                565                 570                 575     
Phe Ser Pro His Asn Ser Gly Arg Pro Met Glu Leu Gln Ile Pro Thr
            580                 585                 590         
Pro Pro Leu Pro Ser Tyr Cys Ser Thr Asn Val Cys Arg Cys Cys Gln
        595                 600                 605             
His His Ser His Ile Gln Tyr Ser Pro Leu Asn Ser Trp Gln Gly Ala
    610                 615                 620                 
Asn Thr Val Gly Ser Ile Gln Asp Val Gln Ser Glu Ala Leu Gln Lys
625                 630                 635                 640 
His Ser Leu Phe His Pro Ser Gly Cys Pro Ala Leu Tyr Cys Asn Ala
                645                 650                 655     
Phe Cys Ser Ser Ser Ser Pro Ile Ala Leu Arg Pro Gln Gly Asp Met
            660                 665                 670         
Gly Ser Cys Ser Pro His Ser Asn Ile Glu Pro Ser Pro Val Ala Arg
        675                 680                 685             
Pro Pro Ser His Met Asp Leu Cys Asn Pro Gln Pro Cys Thr Val Cys
    690                 695                 700                 
Met His Thr Pro Lys Thr Glu Ser Asp Asn Gly Met Met Gly Leu Ser
705                 710                 715                 720 
Pro Asp Ala Tyr Arg Phe Leu Thr Glu Gln Asp Arg Gln Leu Arg Leu
                725                 730                 735     
Leu Gln Ala Gln Ile Gln Arg Leu Leu Glu Ala Gln Ser Leu Met Pro
            740                 745                 750         
Cys Ser Pro Lys Thr Thr Ala Val Glu Asp Thr Val Gln Ala Gly Arg
        755                 760                 765             
Gln Met Glu Leu Val Ser Val Glu Ala Gln Ser Ser Pro Gly Leu His
    770                 775                 780                 
Met Arg Lys Gly Val Ser Ile Ala Val Ser Thr Gly Ala Ser Leu Phe
785                 790                 795                 800 
Trp Asn Ala Ala Gly Glu Asp Gln Glu Pro Asp Ser Gln Met Lys Gln
                805                 810                 815     
Asp Asp Thr Lys Ile Ser Ser Glu Asp Met Asn Phe Ser Val Asp Ile
            820                 825                 830         
Asn Asn Glu Val Thr Ser Leu Pro Gly Ser Ala Ser Ser Leu Lys Ala
        835                 840                 845             
Val Asp Ile Pro Ser Phe Glu Glu Ser Asn Ile Ala Val Glu Glu Glu
    850                 855                 860                 
Phe Asn Gln Pro Leu Ser Val Ser Asn Ser Ser Leu Val Val Arg Lys
865                 870                 875                 880 
Glu Pro Asp Val Pro Val Phe Phe Pro Ser Gly Gln Leu Ala Glu Ser
                885                 890                 895     
Val Ser Met Cys Leu Gln Thr Gly Pro Thr Gly Gly Ala Ser Asn Asn
            900                 905                 910         
Ser Glu Thr Ser Glu Glu Pro Lys Ile Glu His Val Met Gln Pro Leu
        915                 920                 925             
Leu His Gln Pro Ser Asp Asn Gln Lys Ile Tyr Gln Asp Leu Leu Gly
    930                 935                 940                 
Gln Val Asn His Leu Leu Asn Ser Ser Ser Lys Glu Thr Glu Gln Pro
945                 950                 955                 960 
Ser Thr Lys Ala Val Ile Ile Ser His Glu Cys Thr Arg Thr Gln Asn
                965                 970                 975     
Val Tyr His Thr Lys Lys Lys Thr His His Ser Arg Leu Val Asp Lys
            980                 985                 990         
Asp Cys Val Leu Asn Ala Thr Leu Lys Gln Leu Arg Ser Leu Gly Val
        995                 1000                1005            
Lys Ile Asp Ser Pro Thr Lys Val Lys Lys Asn Ala His Asn Val Asp
    1010                1015                1020                
His Ala Ser Val Leu Ala Cys Ile Ser Pro Glu Ala Val Ile Ser Gly
1025                1030                1035                1040
Leu Asn Cys Met Ser Phe Ala Asn Val Gly Met Ser Gly Leu Ser Pro
                1045                1050                1055    
Asn Gly Val Asp Leu Ser Met Glu Ala Asn Ala Ile Ala Leu Lys Tyr
            1060                1065                1070        
Leu Asn Glu Asn Gln Leu Ser Gln Leu Ser Val Thr Arg Ser Asn Gln
        1075                1080                1085            
Asn Asn Cys Asp Pro Phe Ser Leu Leu His Ile Asn Thr Asp Arg Ser
    1090                1095                1100                
Thr Val Gly Leu Ser Leu Ile Ser Pro Asn Asn Met Ser Phe Ala Thr
1105                1110                1115                1120
Lys Lys Tyr Met Lys Arg Tyr Gly Leu Leu Gln Ser Ser Asp Asn Ser
                1125                1130                1135    
Glu Asp Glu Glu Glu Pro Pro Asp Asn Ala Asp Ser Lys Ser Glu Tyr
            1140                1145                1150        
Leu Leu Asn Gln Asn Leu Arg Ser Ile Pro Glu Gln Leu Gly Gly Gln
        1155                1160                1165            
Lys Glu Pro Ser Lys Asn Asp His Glu Ile Ile Asn Cys Ser Asn Cys
    1170                1175                1180                
Glu Ser Val Gly Thr Asn Ala Asp Thr Pro Val Leu Arg Asn Ile Thr
1185                1190                1195                1200
Asn Glu Val Leu Gln Thr Lys Ala Lys Gln Gln Leu Thr Glu Lys Pro
                1205                1210                1215    
Ala Phe Leu Val Lys Asn Leu Lys Pro Ser Pro Ala Val Asn Leu Arg
            1220                1225                1230        
Thr Gly Lys Ala Glu Phe Thr Gln His Pro Glu Lys Glu Asn Glu Gly
        1235                1240                1245            
Asp Ile Thr Ile Phe Pro Glu Ser Leu Gln Pro Ser Glu Thr Leu Lys
    1250                1255                1260                
Gln Met Asn Ser Met Asn Ser Val Gly Thr Phe Leu Asp Val Lys Arg
1265                1270                1275                1280
Leu Arg Gln Leu Pro Lys Leu Phe
                1285            


<210> 7218
<211> 508
<212> PRT
<213> Homo sapiens

<400> 7218
Met Asn Glu Asn Lys Asp Thr Asp Ser Lys Lys Ser Glu Glu Tyr Glu
 1               5                  10                  15      
Asp Asp Phe Glu Lys Asp Leu Glu Trp Leu Ile Asn Glu Asn Glu Lys
            20                  25                  30          
Ser Asp Ala Ser Ile Ile Glu Met Ala Cys Glu Lys Glu Glu Asn Ile
        35                  40                  45              
Asn Gln Asp Leu Lys Glu Asn Glu Thr Val Met Glu His Thr Lys Arg
    50                  55                  60                  
His Ser Asp Pro Asp Lys Ser Leu Gln Asp Glu Val Ser Pro Arg Arg
65                  70                  75                  80  
Asn Asp Ile Ile Ser Val Pro Gly Ile Gln Pro Leu Asp Pro Ile Ser
                85                  90                  95      
Asp Ser Asp Ser Glu Asn Ser Phe Gln Glu Ser Lys Leu Glu Ser Gln
            100                 105                 110         
Lys Asp Leu Glu Glu Glu Glu Asp Glu Glu Val Arg Arg Tyr Ile Met
        115                 120                 125             
Glu Lys Ile Val Gln Ala Asn Lys Leu Leu Gln Asn Gln Glu Pro Val
    130                 135                 140                 
Asn Asp Lys Arg Glu Arg Lys Leu Lys Phe Lys Asp Gln Leu Val Asp
145                 150                 155                 160 
Leu Glu Val Pro Pro Leu Glu Asp Thr Thr Thr Phe Lys Asn Tyr Phe
                165                 170                 175     
Glu Asn Glu Arg Asn Met Phe Gly Lys Leu Ser Gln Leu Cys Ile Ser
            180                 185                 190         
Asn Asp Phe Gly Gln Glu Asp Val Leu Leu Ser Leu Thr Asn Gly Ser
        195                 200                 205             
Cys Glu Glu Asn Lys Asp Arg Thr Ile Leu Val Glu Arg Asp Gly Lys
    210                 215                 220                 
Phe Glu Leu Leu Asn Leu Gln Asp Ile Ala Ser Gln Gly Phe Leu Pro
225                 230                 235                 240 
Pro Ile Asn Asn Ala Asn Ser Thr Glu Asn Asp Pro Gln Gln Leu Leu
                245                 250                 255     
Pro Arg Ser Ser Asn Ser Ser Val Ser Gly Thr Lys Lys Glu Asp Ser
            260                 265                 270         
Thr Ala Lys Ile His Ala Val Thr His Ser Ser Thr Gly Glu Pro Leu
        275                 280                 285             
Ala Tyr Ile Ala Gln Pro Pro Leu Asn Arg Lys Thr Cys Pro Ser Ser
    290                 295                 300                 
Ala Val Asn Ser Asp Arg Ser Lys Gly Asn Gly Lys Ser Asn His Arg
305                 310                 315                 320 
Thr Gln Ser Ala His Ile Ser Pro Val Thr Ser Thr Tyr Cys Leu Ser
                325                 330                 335     
Pro Arg Gln Lys Glu Leu Gln Lys Gln Leu Glu Glu Lys Arg Glu Lys
            340                 345                 350         
Leu Lys Arg Glu Glu Glu Arg Arg Lys Ile Glu Glu Glu Lys Glu Lys
        355                 360                 365             
Lys Arg Glu Asn Asp Ile Val Phe Lys Ala Trp Leu Gln Lys Lys Arg
    370                 375                 380                 
Glu Gln Val Leu Glu Met Arg Arg Ile Gln Arg Ala Lys Glu Ile Glu
385                 390                 395                 400 
Asp Met Asn Ser Arg Glu Asn Arg Asp Pro Gln Gln Ala Phe Arg Leu
                405                 410                 415     
Trp Leu Lys Lys Lys His Glu Glu Gln Met Lys Glu Arg Gln Thr Glu
            420                 425                 430         
Glu Leu Arg Lys Gln Glu Glu Cys Leu Phe Phe Leu Lys Gly Thr Glu
        435                 440                 445             
Gly Arg Glu Arg Ala Phe Lys Gln Trp Leu Arg Arg Lys Arg Met Glu
    450                 455                 460                 
Lys Met Ala Glu Gln Gln Ala Val Arg Glu Arg Thr Arg Gln Leu Arg
465                 470                 475                 480 
Leu Glu Ala Lys Arg Ser Lys Gln Leu Gln His His Leu Tyr Met Ser
                485                 490                 495     
Glu Ala Lys Pro Phe Arg Phe Thr Asp His Tyr Asn
            500                 505             


<210> 7219
<211> 1175
<212> PRT
<213> Homo sapiens

<400> 7219
Met Asn Gly Asp Met Pro His Val Pro Ile Thr Thr Leu Ala Gly Ile
 1               5                  10                  15      
Ala Ser Leu Thr Asp Leu Leu Asn Gln Leu Pro Leu Pro Ser Pro Leu
            20                  25                  30          
Pro Ala Thr Thr Thr Lys Ser Leu Leu Phe Asn Ala Arg Ile Ala Glu
        35                  40                  45              
Glu Val Asn Cys Leu Leu Ala Cys Arg Asp Asp Asn Leu Val Ser Gln
    50                  55                  60                  
Leu Val His Ser Leu Asn Gln Val Ser Thr Asp His Ile Glu Leu Lys
65                  70                  75                  80  
Asp Asn Leu Gly Ser Asp Asp Pro Glu Gly Asp Ile Pro Val Leu Leu
                85                  90                  95      
Gln Ala Val Leu Ala Arg Ser Pro Asn Val Phe Arg Glu Lys Ser Met
            100                 105                 110         
Gln Asn Arg Tyr Val Gln Ser Gly Met Met Met Ser Gln Tyr Lys Leu
        115                 120                 125             
Ser Gln Asn Ser Met His Ser Ser Pro Ala Ser Ser Asn Tyr Gln Gln
    130                 135                 140                 
Thr Thr Ile Ser His Ser Pro Ser Ser Arg Phe Val Pro Pro Gln Thr
145                 150                 155                 160 
Ser Ser Gly Asn Arg Phe Met Pro Gln Gln Asn Ser Pro Val Pro Ser
                165                 170                 175     
Pro Tyr Ala Pro Gln Ser Pro Ala Gly Tyr Met Pro Tyr Ser His Pro
            180                 185                 190         
Ser Ser Tyr Thr Thr His Pro Gln Met Gln Gln Ala Ser Val Ser Ser
        195                 200                 205             
Pro Ile Val Ala Gly Gly Leu Arg Asn Ile His Asp Asn Lys Val Ser
    210                 215                 220                 
Gly Pro Leu Ser Gly Asn Ser Ala Asn His His Ala Asp Asn Pro Arg
225                 230                 235                 240 
His Gly Ser Ser Glu Asp Tyr Leu His Met Val His Arg Leu Ser Ser
                245                 250                 255     
Asp Asp Gly Asp Ser Ser Thr Met Arg Asn Ala Ala Ser Phe Pro Leu
            260                 265                 270         
Arg Ser Pro Gln Pro Val Cys Ser Pro Ala Gly Ser Glu Gly Thr Pro
        275                 280                 285             
Lys Gly Ser Arg Pro Pro Leu Ile Leu Gln Ser Gln Ser Leu Pro Cys
    290                 295                 300                 
Ser Ser Pro Arg Asp Val Pro Pro Asp Ile Leu Leu Asp Ser Pro Glu
305                 310                 315                 320 
Arg Lys Gln Lys Lys Gln Lys Lys Met Lys Leu Gly Lys Asp Glu Lys
                325                 330                 335     
Glu Gln Ser Glu Lys Ala Ala Met Tyr Asp Ile Ile Ser Ser Pro Ser
            340                 345                 350         
Lys Asp Ser Thr Lys Leu Thr Leu Arg Leu Ser Arg Val Arg Ser Ser
        355                 360                 365             
Asp Met Asp Gln Gln Glu Asp Met Ile Ser Gly Val Glu Asn Ser Asn
    370                 375                 380                 
Val Ser Glu Asn Asp Ile Pro Phe Asn Val Gln Tyr Pro Gly Gln Thr
385                 390                 395                 400 
Ser Lys Thr Pro Ile Thr Pro Gln Asp Ile Asn Arg Pro Leu Asn Ala
                405                 410                 415     
Ala Gln Cys Leu Ser Gln Gln Glu Gln Thr Ala Phe Leu Pro Ala Asn
            420                 425                 430         
Gln Val Pro Val Leu Gln Gln Asn Thr Ser Val Ala Ala Lys Gln Pro
        435                 440                 445             
Gln Thr Ser Val Val Gln Asn Gln Gln Gln Ile Ser Gln Gln Gly Pro
    450                 455                 460                 
Ile Tyr Asp Glu Val Glu Leu Asp Ala Leu Ala Glu Ile Glu Arg Ile
465                 470                 475                 480 
Glu Arg Glu Ser Ala Ile Glu Arg Glu Arg Phe Ser Lys Glu Val Gln
                485                 490                 495     
Asp Lys Asp Lys Pro Leu Lys Lys Arg Lys Gln Asp Ser Tyr Pro Gln
            500                 505                 510         
Glu Ala Gly Gly Ala Thr Gly Gly Asn Arg Pro Ala Ser Gln Glu Thr
        515                 520                 525             
Gly Ser Thr Gly Asn Gly Ser Arg Pro Ala Leu Met Val Ser Ile Asp
    530                 535                 540                 
Leu His Gln Thr Gly Arg Val Asp Ser Gln Ala Ser Ile Thr Gln Asp
545                 550                 555                 560 
Ser Asp Ser Ile Lys Lys Pro Glu Glu Ile Lys Gln Cys Ser Asp Ala
                565                 570                 575     
Pro Val Ser Val Leu Gln Glu Asp Ile Val Gly Ser Leu Lys Ser Thr
            580                 585                 590         
Pro Glu Asn His Pro Glu Thr Pro Lys Lys Lys Ser Asp Pro Glu Leu
        595                 600                 605             
Ser Lys Ser Glu Met Lys Gln Ser Glu Ser Arg Leu Ala Glu Ser Lys
    610                 615                 620                 
Pro Asn Glu Asn Arg Leu Val Glu Thr Lys Ser Ser Glu Asn Lys Leu
625                 630                 635                 640 
Glu Thr Lys Val Glu Thr Gln Ile Glu Glu Leu Lys Gln Asn Glu Ser
                645                 650                 655     
Arg Thr Thr Glu Cys Lys Gln Asn Glu Ser Thr Ile Val Glu Pro Lys
            660                 665                 670         
Gln Asn Glu Asn Arg Leu Ser Asp Thr Lys Pro Asn Asp Asn Lys Gln
        675                 680                 685             
Asn Asn Gly Arg Ser Glu Thr Thr Lys Ser Arg Pro Glu Thr Pro Lys
    690                 695                 700                 
Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro Lys Gln Lys Ser Asp Gly
705                 710                 715                 720 
His Pro Glu Thr Pro Lys Gln Lys Gly Asp Gly Arg Pro Glu Thr Pro
                725                 730                 735     
Lys Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro Lys Gln Lys Asn Glu
            740                 745                 750         
Gly Arg Pro Glu Thr Pro Lys His Arg His Asp Asn Arg Arg Asp Ser
        755                 760                 765             
Gly Lys Pro Ser Thr Glu Lys Lys Pro Glu Val Ser Lys His Lys Gln
    770                 775                 780                 
Asp Thr Lys Ser Asp Ser Pro Arg Leu Lys Ser Glu Arg Ala Glu Ala
785                 790                 795                 800 
Leu Lys Gln Arg Pro Asp Gly Arg Ser Val Ser Glu Ser Leu Arg Arg
                805                 810                 815     
Asp His Asp Asn Lys Gln Lys Ser Asp Asp Arg Gly Glu Ser Glu Arg
            820                 825                 830         
His Arg Gly Asp Gln Ser Arg Val Arg Arg Pro Glu Thr Leu Arg Ser
        835                 840                 845             
Ser Ser Arg Asn Glu His Gly Ile Lys Ser Asp Ser Ser Lys Thr Asp
    850                 855                 860                 
Lys Leu Glu Arg Lys His Arg His Glu Ser Gly Asp Ser Arg Glu Arg
865                 870                 875                 880 
Pro Ser Ser Gly Glu Gln Lys Ser Arg Pro Asp Ser Pro Arg Val Lys
                885                 890                 895     
Gln Gly Asp Ser Asn Lys Ser Arg Ser Asp Lys Leu Gly Phe Lys Ser
            900                 905                 910         
Pro Thr Ser Lys Asp Asp Lys Arg Thr Glu Gly Asn Lys Ser Lys Val
        915                 920                 925             
Asp Thr Asn Lys Ala His Pro Asp Asn Lys Ala Glu Phe Pro Ser Tyr
    930                 935                 940                 
Leu Leu Gly Gly Arg Ser Gly Ala Leu Lys Asn Phe Val Ile Pro Lys
945                 950                 955                 960 
Ile Lys Arg Asp Lys Asp Gly Asn Val Thr Gln Glu Thr Lys Lys Met
                965                 970                 975     
Glu Met Lys Gly Glu Pro Lys Asp Lys Val Glu Lys Ile Gly Leu Val
            980                 985                 990         
Glu Asp Leu Asn Lys Gly Ala Lys Pro Val Val Val Leu Gln Lys Leu
        995                 1000                1005            
Ser Leu Asp Asp Val Gln Lys Leu Ile Lys Asp Arg Glu Asp Lys Ser
    1010                1015                1020                
Arg Ser Ser Leu Lys Pro Ile Lys Asn Lys Pro Ser Lys Ser Asn Lys
1025                1030                1035                1040
Gly Ser Ile Asp Gln Ser Val Leu Lys Glu Leu Pro Pro Glu Leu Leu
                1045                1050                1055    
Ala Glu Ile Glu Ser Thr Met Pro Leu Cys Glu Arg Val Lys Met Asn
            1060                1065                1070        
Lys Arg Lys Arg Ser Thr Val Asn Glu Lys Pro Lys Tyr Ala Glu Ile
        1075                1080                1085            
Ser Ser Asp Glu Asp Asn Asp Ser Asp Glu Ala Phe Glu Ser Ser Arg
    1090                1095                1100                
Lys Arg His Lys Lys Asp Asp Asp Lys Ala Trp Glu Tyr Glu Glu Arg
1105                1110                1115                1120
Asp Arg Arg Ser Ser Gly Asp His Arg Arg Ser Gly His Ser His Glu
                1125                1130                1135    
Gly Arg Arg Ser Ser Gly Gly Gly Arg Tyr Arg Asn Arg Ser Pro Ser
            1140                1145                1150        
Asp Ser Asp Met Glu Asp Tyr Ser Pro Pro Pro Ser Leu Ser Glu Val
        1155                1160                1165            
Ala Arg Lys Lys Lys Lys Lys
    1170                1175


<210> 7220
<211> 259
<212> PRT
<213> Homo sapiens

<400> 7220
Met Trp Ser Arg Asp Asp His Thr Cys Gly Ile Ile Arg Glu Asn Thr
 1               5                  10                  15      
Met Ala Arg His Pro Arg Thr Ala Gly Ser Phe Pro Ala Phe Lys Thr
            20                  25                  30          
Glu Met Gln Pro Ser Ala Asp Thr Gln Gln Pro Thr Pro Pro Gly Pro
        35                  40                  45              
Asn His Arg Gly Lys Arg Thr Ala Asn Arg Tyr Thr His His Pro His
    50                  55                  60                  
Gly Gly Gln Arg Ala Leu Pro Val His Met Ala Asp Ala Ile Gly His
65                  70                  75                  80  
Gly Arg Ala Asp Arg Lys Gly Leu Phe Pro Pro Thr Gln Lys Asn Ala
                85                  90                  95      
Leu Gln Ile Ala Thr Pro Thr Ile Pro Met Ala Asp Ser Val His Phe
            100                 105                 110         
Pro Ser Thr Arg Gln Met Leu Gly Leu Glu Glu Thr Leu Ser Arg Leu
        115                 120                 125             
Leu Ser Ala Phe Val Leu Pro Arg Asp Pro Val Thr Leu Glu Gly Ala
    130                 135                 140                 
Ala Leu Ala Ser Asn Arg Lys Arg Val Asn Val Ala Ala Asp Gln Gly
145                 150                 155                 160 
Ser Leu Pro Ala Gly Ser Ser Cys Leu Ala Leu Gly Asn Ile Phe Pro
                165                 170                 175     
Leu Gln Pro Arg Ala Ser Thr Arg Leu Pro Arg Trp Ile Arg Pro Gln
            180                 185                 190         
Arg Cys Val Pro Ala Ser Phe Leu Ile Leu Ser Leu Lys Arg Ser Arg
        195                 200                 205             
Asp Phe Ser Ala Ala Pro Gln Asn Thr Thr Gln Asn Phe Leu Val Asn
    210                 215                 220                 
Gly Arg Ile Arg Lys Trp Met Ala Trp Leu Thr Glu Leu Arg Asn Ser
225                 230                 235                 240 
Ser Trp Lys Phe Ser Ala Asn Val Leu Leu Val Gln His Leu Gln Trp
                245                 250                 255     
Trp Pro Thr
            


<210> 7221
<211> 882
<212> PRT
<213> Homo sapiens

<400> 7221
Met Ala Ala Asp Lys Gly Pro Ala Ala Gly Pro Arg Ser Arg Ala Ala
 1               5                  10                  15      
Met Ala Gln Trp Arg Lys Lys Lys Gly Leu Arg Lys Arg Arg Gly Ala
            20                  25                  30          
Ala Ser Gln Ala Arg Gly Ser Asp Ser Glu Asp Gly Glu Phe Glu Ile
        35                  40                  45              
Gln Ala Glu Asp Asp Ala Arg Ala Arg Lys Leu Gly Pro Gly Arg Pro
    50                  55                  60                  
Leu Pro Thr Phe Pro Thr Ser Glu Cys Thr Ser Asp Val Glu Pro Asp
65                  70                  75                  80  
Thr Arg Glu Met Val Arg Ala Gln Asn Lys Lys Lys Lys Lys Ser Gly
                85                  90                  95      
Gly Phe Gln Ser Met Gly Leu Ser Tyr Pro Val Phe Lys Gly Ile Met
            100                 105                 110         
Lys Lys Gly Tyr Lys Val Pro Thr Pro Ile Gln Arg Lys Thr Ile Pro
        115                 120                 125             
Val Ile Leu Asp Gly Lys Asp Val Val Ala Met Ala Arg Thr Gly Ser
    130                 135                 140                 
Gly Lys Thr Ala Cys Phe Leu Leu Pro Met Phe Glu Arg Leu Lys Thr
145                 150                 155                 160 
His Ser Ala Gln Thr Gly Ala Arg Ala Leu Ile Leu Ser Pro Thr Arg
                165                 170                 175     
Glu Leu Ala Leu Gln Thr Leu Lys Phe Thr Lys Glu Leu Gly Lys Phe
            180                 185                 190         
Thr Gly Leu Lys Thr Ala Leu Ile Leu Gly Gly Asp Arg Met Glu Asp
        195                 200                 205             
Gln Phe Ala Ala Leu His Glu Asn Pro Asp Ile Ile Ile Ala Thr Pro
    210                 215                 220                 
Gly Arg Leu Val His Val Ala Val Glu Met Ser Leu Lys Leu Gln Ser
225                 230                 235                 240 
Val Glu Tyr Val Val Phe Asp Glu Ala Asp Arg Leu Phe Glu Met Gly
                245                 250                 255     
Phe Ala Glu Gln Leu Gln Glu Ile Ile Ala Arg Leu Pro Gly Gly His
            260                 265                 270         
Gln Thr Val Leu Phe Ser Ala Thr Leu Pro Lys Leu Leu Val Glu Phe
        275                 280                 285             
Ala Arg Ala Gly Leu Thr Glu Pro Val Leu Ile Arg Leu Asp Val Asp
    290                 295                 300                 
Thr Lys Leu Asn Glu Gln Leu Lys Thr Ser Phe Phe Leu Val Arg Glu
305                 310                 315                 320 
Asp Thr Lys Ala Ala Val Leu Leu His Leu Leu His Asn Val Val Arg
                325                 330                 335     
Pro Gln Asp Gln Thr Val Val Phe Val Ala Thr Lys His His Ala Glu
            340                 345                 350         
Tyr Leu Thr Glu Leu Leu Thr Thr Gln Arg Val Ser Cys Ala His Ile
        355                 360                 365             
Tyr Ser Ala Leu Asp Pro Thr Ala Arg Lys Ile Asn Leu Ala Lys Phe
    370                 375                 380                 
Thr Leu Gly Lys Cys Ser Thr Leu Ile Val Thr Asp Leu Ala Ala Arg
385                 390                 395                 400 
Gly Leu Asp Ile Pro Leu Leu Asp Asn Val Ile Asn Tyr Ser Phe Pro
                405                 410                 415     
Ala Lys Gly Lys Leu Phe Leu His Arg Val Gly Arg Val Ala Arg Ala
            420                 425                 430         
Gly Arg Ser Gly Thr Ala Tyr Ser Leu Val Ala Pro Asp Glu Ile Pro
        435                 440                 445             
Tyr Leu Leu Asp Leu His Leu Phe Leu Gly Arg Ser Leu Thr Leu Ala
    450                 455                 460                 
Arg Pro Leu Lys Glu Pro Ser Gly Val Ala Gly Val Asp Gly Met Leu
465                 470                 475                 480 
Gly Arg Val Pro Gln Ser Val Val Asp Glu Glu Asp Ser Gly Leu Gln
                485                 490                 495     
Ser Thr Leu Glu Ala Ser Leu Glu Leu Arg Gly Leu Ala Arg Val Ala
            500                 505                 510         
Asp Asn Ala Gln Gln Gln Tyr Val Arg Ser Arg Pro Ala Pro Ser Pro
        515                 520                 525             
Glu Ser Ile Lys Arg Ala Lys Glu Met Asp Leu Val Gly Leu Gly Leu
    530                 535                 540                 
His Pro Leu Phe Ser Ser Arg Phe Glu Glu Glu Glu Leu Gln Arg Leu
545                 550                 555                 560 
Arg Leu Val Asp Ser Ile Lys Asn Tyr Arg Ser Arg Ala Thr Ile Phe
                565                 570                 575     
Glu Ile Asn Ala Ser Ser Arg Asp Leu Cys Ser Gln Val Met Arg Ala
            580                 585                 590         
Lys Arg Gln Lys Asp Arg Lys Ala Ile Ala Arg Phe Gln Gln Gly Gln
        595                 600                 605             
Gln Gly Arg Gln Glu Gln Gln Glu Gly Pro Val Gly Pro Ala Pro Ser
    610                 615                 620                 
Arg Pro Ala Leu Gln Glu Lys Gln Pro Glu Lys Glu Glu Glu Glu Glu
625                 630                 635                 640 
Ala Gly Glu Ser Val Glu Asp Ile Phe Ser Glu Val Val Gly Arg Lys
                645                 650                 655     
Arg Gln Arg Ser Gly Pro Asn Arg Gly Ala Lys Arg Arg Arg Glu Glu
            660                 665                 670         
Ala Arg Gln Arg Asp Gln Glu Phe Tyr Ile Pro Tyr Arg Pro Lys Asp
        675                 680                 685             
Phe Asp Ser Glu Arg Gly Leu Ser Ile Ser Gly Glu Gly Gly Ala Phe
    690                 695                 700                 
Glu Gln Gln Ala Ala Gly Ala Val Leu Asp Leu Met Gly Asp Glu Ala
705                 710                 715                 720 
Gln Asn Leu Thr Arg Gly Arg Gln Gln Leu Lys Trp Asp Arg Lys Lys
                725                 730                 735     
Lys Arg Phe Val Gly Gln Ser Gly Gln Glu Asp Lys Lys Lys Ile Lys
            740                 745                 750         
Thr Glu Ser Gly Arg Tyr Ile Ser Ser Ser Tyr Lys Arg Asp Leu Tyr
        755                 760                 765             
Gln Lys Trp Lys Gln Lys Gln Lys Ile Asp Asp Arg Asp Ser Asp Glu
    770                 775                 780                 
Glu Gly Ala Ser Asp Arg Arg Gly Pro Glu Arg Arg Gly Gly Lys Arg
785                 790                 795                 800 
Asp Arg Gly Gln Ala Gly Ala Ser Arg Pro His Ala Pro Gly Thr Pro
                805                 810                 815     
Ala Gly Arg Val Arg Pro Glu Leu Lys Thr Lys Gln Gln Ile Leu Lys
            820                 825                 830         
Gln Arg Arg Arg Ala Gln Lys Leu His Phe Leu Gln Arg Gly Gly Leu
        835                 840                 845             
Lys Gln Leu Ser Ala Arg Asn Arg Arg Arg Val Gln Glu Leu Gln Gln
    850                 855                 860                 
Gly Ala Phe Gly Arg Gly Ala Arg Ser Lys Lys Gly Lys Met Arg Lys
865                 870                 875                 880 
Arg Met
        


<210> 7222
<211> 138
<212> PRT
<213> Homo sapiens

<400> 7222
Met Asp Thr Gln Thr His Ser Leu Pro Ile Thr His Thr Gln Leu His
 1               5                  10                  15      
Ser Asn Ser Gln Pro Gln Ser Arg Thr Cys Thr Arg His Cys Gln Thr
            20                  25                  30          
Phe Ser Gln Ser Cys Arg Gln Ser His Arg Gly Ser Arg Ser Gln Ser
        35                  40                  45              
Ser Ser Gln Ser Pro Ala Ser His Arg Asn Pro Thr Gly Ala His Ser
    50                  55                  60                  
Ser Ser Gly His Gln Ser Gln Ser Pro Asn Thr Ser Pro Pro Pro Lys
65                  70                  75                  80  
Arg His Lys Lys Thr Met Asn Ser His His Ser Pro Met Arg Pro Thr
                85                  90                  95      
Ile Leu His Cys Arg Cys Pro Lys Asn Arg Lys Asn Leu Glu Gly Lys
            100                 105                 110         
Leu Lys Lys Lys Lys Met Ala Lys Arg Ile Gln Gln Val Tyr Lys Thr
        115                 120                 125             
Lys Thr Arg Ser Ser Gly Trp Lys Ser Asn
    130                 135             


<210> 7223
<211> 1093
<212> PRT
<213> Homo sapiens

<400> 7223
Met Ala Asp Ser Ser Ser Ser Ser Phe Phe Pro Asp Phe Gly Leu Leu
 1               5                  10                  15      
Leu Tyr Leu Glu Glu Leu Asn Lys Glu Glu Leu Asn Thr Phe Lys Leu
            20                  25                  30          
Phe Leu Lys Glu Thr Met Glu Pro Glu His Gly Leu Thr Pro Trp Asn
        35                  40                  45              
Glu Val Lys Lys Ala Arg Arg Glu Asp Leu Ala Asn Leu Met Lys Lys
    50                  55                  60                  
Tyr Tyr Pro Gly Glu Lys Ala Trp Ser Val Ser Leu Lys Ile Phe Gly
65                  70                  75                  80  
Lys Met Asn Leu Lys Asp Leu Cys Glu Arg Ala Lys Glu Glu Ile Asn
                85                  90                  95      
Trp Ser Ala Gln Thr Ile Gly Pro Asp Asp Ala Lys Ala Gly Glu Thr
            100                 105                 110         
Gln Glu Asp Gln Glu Ala Val Leu Gly Asp Gly Thr Glu Tyr Arg Asn
        115                 120                 125             
Arg Ile Lys Glu Lys Phe Cys Ile Thr Trp Asp Lys Lys Ser Leu Ala
    130                 135                 140                 
Gly Lys Pro Glu Asp Phe His His Gly Ile Ala Glu Lys Asp Arg Lys
145                 150                 155                 160 
Leu Leu Glu His Leu Phe Asp Val Asp Val Lys Thr Gly Ala Gln Pro
                165                 170                 175     
Gln Ile Val Val Leu Gln Gly Ala Ala Gly Val Gly Lys Thr Thr Leu
            180                 185                 190         
Val Arg Lys Ala Met Leu Asp Trp Ala Glu Gly Ser Leu Tyr Gln Gln
        195                 200                 205             
Arg Phe Lys Tyr Val Phe Tyr Leu Asn Gly Arg Glu Ile Asn Gln Leu
    210                 215                 220                 
Lys Glu Arg Ser Phe Ala Gln Leu Ile Ser Lys Asp Trp Pro Ser Thr
225                 230                 235                 240 
Glu Gly Pro Ile Glu Glu Ile Met Tyr Gln Pro Ser Ser Leu Leu Phe
                245                 250                 255     
Ile Ile Asp Ser Phe Asp Glu Leu Asn Phe Ala Phe Glu Glu Pro Glu
            260                 265                 270         
Phe Ala Leu Cys Glu Asp Trp Thr Gln Glu His Pro Val Ser Phe Leu
        275                 280                 285             
Met Ser Ser Leu Leu Arg Lys Val Met Leu Pro Glu Ala Ser Leu Leu
    290                 295                 300                 
Val Thr Thr Arg Leu Thr Thr Ser Lys Arg Leu Lys Gln Leu Leu Lys
305                 310                 315                 320 
Asn His His Tyr Val Glu Leu Leu Gly Met Ser Glu Asp Ala Arg Glu
                325                 330                 335     
Glu Tyr Ile Tyr Gln Phe Phe Glu Asp Lys Arg Trp Ala Met Lys Val
            340                 345                 350         
Phe Ser Ser Leu Lys Ser Asn Glu Met Leu Phe Ser Met Cys Gln Val
        355                 360                 365             
Pro Leu Val Cys Trp Ala Ala Cys Thr Cys Leu Lys Gln Gln Met Glu
    370                 375                 380                 
Lys Gly Gly Asp Val Thr Leu Thr Cys Gln Thr Thr Thr Ala Leu Phe
385                 390                 395                 400 
Thr Cys Tyr Ile Ser Ser Leu Phe Thr Pro Val Asp Gly Gly Ser Pro
                405                 410                 415     
Ser Leu Pro Asn Gln Ala Gln Leu Arg Arg Leu Cys Gln Val Ala Ala
            420                 425                 430         
Lys Gly Ile Trp Thr Met Thr Tyr Val Phe Tyr Arg Glu Asn Leu Arg
        435                 440                 445             
Arg Leu Gly Leu Thr Gln Ser Asp Val Ser Ser Phe Met Asp Ser Asn
    450                 455                 460                 
Ile Ile Gln Lys Asp Ala Glu Tyr Glu Asn Cys Tyr Val Phe Thr His
465                 470                 475                 480 
Leu His Val Gln Glu Phe Phe Ala Ala Met Phe Tyr Met Leu Lys Gly
                485                 490                 495     
Ser Trp Glu Ala Gly Asn Pro Ser Cys Gln Pro Phe Glu Asp Leu Lys
            500                 505                 510         
Ser Leu Leu Gln Ser Thr Ser Tyr Lys Asp Pro His Leu Thr Gln Met
        515                 520                 525             
Lys Cys Phe Leu Phe Gly Leu Leu Asn Glu Asp Arg Val Lys Gln Leu
    530                 535                 540                 
Glu Arg Thr Phe Asn Cys Lys Met Ser Leu Lys Ile Lys Ser Lys Leu
545                 550                 555                 560 
Leu Gln Cys Met Glu Val Leu Gly Asn Ser Asp Tyr Ser Pro Ser Gln
                565                 570                 575     
Leu Gly Phe Leu Glu Leu Phe His Cys Leu Tyr Glu Thr Gln Asp Lys
            580                 585                 590         
Ala Phe Ile Ser Gln Ala Met Arg Cys Phe Pro Lys Val Ala Ile Asn
        595                 600                 605             
Ile Cys Glu Lys Ile His Leu Leu Val Ser Ser Phe Cys Leu Lys His
    610                 615                 620                 
Cys Arg Cys Leu Arg Thr Ile Arg Leu Ser Val Thr Val Val Phe Glu
625                 630                 635                 640 
Lys Lys Ile Leu Lys Thr Ser Leu Pro Thr Asn Thr Trp Asp Gly Asp
                645                 650                 655     
Arg Ile Thr His Cys Trp Gln Asp Leu Cys Ser Val Leu His Thr Asn
            660                 665                 670         
Glu His Leu Arg Glu Leu Asp Leu Tyr His Ser Asn Leu Asp Lys Ser
        675                 680                 685             
Ala Met Asn Ile Leu His His Glu Leu Arg His Pro Asn Cys Lys Leu
    690                 695                 700                 
Gln Lys Leu Leu Leu Lys Phe Ile Thr Phe Pro Asp Gly Cys Gln Asp
705                 710                 715                 720 
Ile Ser Thr Ser Leu Ile His Asn Lys Asn Leu Met His Leu Asp Leu
                725                 730                 735     
Lys Gly Ser Asp Ile Gly Asp Asn Gly Val Lys Ser Leu Cys Glu Ala
            740                 745                 750         
Leu Lys His Pro Glu Cys Lys Leu Gln Thr Leu Arg Leu Glu Ser Cys
        755                 760                 765             
Asn Leu Thr Val Phe Cys Cys Leu Asn Ile Ser Asn Ala Leu Ile Arg
    770                 775                 780                 
Ser Gln Ser Leu Ile Phe Leu Asn Leu Ser Thr Asn Asn Leu Leu Asp
785                 790                 795                 800 
Asp Gly Val Gln Leu Leu Cys Glu Ala Leu Arg His Pro Lys Cys Tyr
                805                 810                 815     
Leu Glu Arg Leu Ser Leu Glu Ser Cys Gly Leu Thr Glu Ala Gly Cys
            820                 825                 830         
Glu Tyr Leu Ser Leu Ala Leu Ile Ser Asn Lys Arg Leu Thr His Leu
        835                 840                 845             
Cys Leu Ala Asp Asn Val Leu Gly Asp Gly Gly Val Lys Leu Met Ser
    850                 855                 860                 
Asp Ala Leu Gln His Ala Gln Cys Thr Leu Lys Ser Leu Val Leu Arg
865                 870                 875                 880 
Arg Cys His Phe Thr Ser Leu Ser Ser Glu Tyr Leu Ser Thr Ser Leu
                885                 890                 895     
Leu His Asn Lys Ser Leu Thr His Leu Asp Leu Gly Ser Asn Trp Leu
            900                 905                 910         
Gln Asp Asn Gly Val Lys Leu Leu Cys Asp Val Phe Arg His Pro Ser
        915                 920                 925             
Cys Asn Leu Gln Asp Leu Glu Leu Met Gly Cys Val Leu Thr Asn Ala
    930                 935                 940                 
Cys Cys Leu Asp Leu Ala Ser Val Ile Leu Asn Asn Pro Asn Leu Arg
945                 950                 955                 960 
Ser Leu Asp Leu Gly Asn Asn Asp Leu Gln Asp Asp Gly Val Lys Ile
                965                 970                 975     
Leu Cys Asp Ala Leu Arg Tyr Pro Asn Cys Asn Ile Gln Arg Leu Gly
            980                 985                 990         
Leu Glu Tyr Cys Gly Leu Thr Ser Leu Cys Cys Gln Asp Leu Ser Ser
        995                 1000                1005            
Ala Leu Ile Cys Asn Lys Arg Leu Ile Lys Met Asn Leu Thr Gln Asn
    1010                1015                1020                
Thr Leu Gly Tyr Glu Gly Ile Val Lys Leu Tyr Lys Val Leu Lys Ser
1025                1030                1035                1040
Pro Lys Cys Lys Leu Gln Val Leu Gly Leu Cys Lys Glu Ala Phe Asp
                1045                1050                1055    
Glu Glu Ala Gln Lys Leu Leu Glu Ala Val Gly Val Ser Asn Pro His
            1060                1065                1070        
Leu Ile Ile Lys Pro Asp Cys Asn Tyr His Asn Glu Glu Asp Val Ser
        1075                1080                1085            
Trp Trp Trp Cys Phe
    1090            


<210> 7224
<211> 176
<212> PRT
<213> Homo sapiens

<400> 7224
Met Gln Gln Gln Glu Lys Leu Ile Gln Gln Glu Arg Ala Leu Leu Asn
 1               5                  10                  15      
Phe Thr Glu Trp Lys Arg Ser Cys Ala Leu Gln Met Lys Tyr Cys Gln
            20                  25                  30          
Ala Phe Met Gln Asn Ser Leu Ser Ser Ala His Asn Ser Ser Pro Cys
        35                  40                  45              
Pro Asn Asn Trp Ile Gln Asn Arg Glu Ser Cys Tyr Tyr Val Ser Glu
    50                  55                  60                  
Ile Trp Ser Ile Trp His Thr Ser Gln Glu Asn Cys Leu Lys Glu Gly
65                  70                  75                  80  
Ser Thr Leu Leu Gln Ile Glu Ser Lys Glu Glu Met Asp Phe Ile Thr
                85                  90                  95      
Gly Ser Leu Arg Lys Ile Lys Gly Ser Tyr Asp Tyr Trp Val Gly Leu
            100                 105                 110         
Ser Gln Asp Gly His Ser Gly Arg Trp Leu Trp Gln Asp Gly Ser Ser
        115                 120                 125             
Pro Ser Pro Gly Leu Leu Pro Ala Glu Arg Ser Gln Ser Ala Asn Gln
    130                 135                 140                 
Val Cys Gly Tyr Val Lys Ser Asn Ser Leu Leu Ser Ser Asn Cys Ser
145                 150                 155                 160 
Thr Trp Lys Tyr Phe Ile Cys Glu Lys Tyr Ala Leu Arg Ser Ser Val
                165                 170                 175     


<210> 7225
<211> 669
<212> PRT
<213> Homo sapiens

<400> 7225
Cys Arg Ser Arg Arg Gly Ile Arg Arg Val Glu Pro Leu Arg Arg Ala
 1               5                  10                  15      
Arg Ala Arg Val Gly Pro Arg Phe Arg Pro Leu Cys Arg Met Glu Ile
            20                  25                  30          
Ile Arg Ser Asn Phe Lys Ser Asn Leu His Lys Val Tyr Gln Ala Ile
        35                  40                  45              
Glu Glu Ala Asp Phe Phe Ala Ile Asp Gly Glu Phe Ser Gly Ile Ser
    50                  55                  60                  
Asp Gly Pro Ser Val Ser Ala Leu Thr Asn Gly Phe Asp Thr Pro Glu
65                  70                  75                  80  
Glu Arg Cys Phe Ile Ser Leu Phe Gln His Ser Met Asp Phe Leu Leu
                85                  90                  95      
Phe Gln Phe Gly Leu Cys Thr Phe Lys Tyr Asp Tyr Thr Asp Ser Lys
            100                 105                 110         
Tyr Ile Thr Lys Ser Phe Asn Phe Tyr Val Phe Pro Lys Pro Phe Asn
        115                 120                 125             
Arg Ser Ser Pro Asp Val Lys Phe Val Cys Gln Ser Ser Ser Ile Asp
    130                 135                 140                 
Phe Leu Ala Ser Gln Gly Phe Asp Phe Asn Lys Val Phe Arg Asn Gly
145                 150                 155                 160 
Ile Pro Tyr Leu Asn Gln Glu Glu Glu Arg Gln Leu Arg Glu Gln Tyr
                165                 170                 175     
Asp Glu Lys Arg Ser Gln Ala Asn Gly Ala Gly Ala Leu Ser Tyr Val
            180                 185                 190         
Ser Pro Asn Thr Ser Lys Cys Pro Val Thr Ile Pro Glu Asp Gln Lys
        195                 200                 205             
Lys Phe Ile Asp Gln Val Val Glu Lys Ile Glu Asp Leu Leu Gln Ser
    210                 215                 220                 
Glu Glu Asn Lys Asn Leu Asp Leu Glu Pro Cys Thr Gly Phe Gln Arg
225                 230                 235                 240 
Lys Leu Ile Tyr Gln Thr Leu Ser Trp Lys Tyr Pro Lys Gly Ile His
                245                 250                 255     
Val Glu Thr Leu Glu Thr Glu Lys Lys Glu Arg Tyr Ile Val Ile Ser
            260                 265                 270         
Lys Val Asp Glu Glu Glu Arg Lys Arg Arg Glu Gln Gln Lys His Ala
        275                 280                 285             
Lys Glu Gln Glu Glu Leu Asn Asp Ala Val Gly Phe Ser Arg Val Ile
    290                 295                 300                 
His Ala Ile Ala Asn Ser Gly Lys Leu Val Ile Gly His Asn Met Leu
305                 310                 315                 320 
Leu Asp Val Met His Thr Val His Gln Phe Tyr Cys Pro Leu Pro Ala
                325                 330                 335     
Asp Leu Ser Glu Phe Lys Glu Met Thr Thr Cys Val Phe Pro Arg Leu
            340                 345                 350         
Leu Asp Thr Lys Leu Met Ala Ser Thr Gln Pro Phe Lys Asp Ile Ile
        355                 360                 365             
Asn Asn Thr Ser Leu Ala Glu Leu Glu Lys Arg Leu Lys Glu Thr Pro
    370                 375                 380                 
Phe Asn Pro Pro Lys Val Glu Ser Ala Glu Gly Phe Pro Ser Tyr Asp
385                 390                 395                 400 
Thr Ala Ser Glu Gln Leu His Glu Ala Gly Tyr Asp Ala Tyr Ile Thr
                405                 410                 415     
Gly Leu Cys Phe Ile Ser Met Ala Asn Tyr Leu Gly Ser Phe Leu Ser
            420                 425                 430         
Pro Pro Lys Ile His Val Ser Ala Arg Ser Lys Leu Ile Glu Pro Phe
        435                 440                 445             
Phe Asn Lys Leu Phe Leu Met Arg Val Met Asp Ile Pro Tyr Leu Asn
    450                 455                 460                 
Leu Glu Gly Pro Asp Leu Gln Pro Lys Arg Asp His Val Leu His Val
465                 470                 475                 480 
Thr Phe Pro Lys Glu Trp Lys Thr Ser Asp Leu Tyr Gln Leu Phe Ser
                485                 490                 495     
Ala Phe Gly Asn Ile Gln Ile Ser Trp Ile Asp Asp Thr Ser Ala Phe
            500                 505                 510         
Val Ser Leu Ser Gln Pro Glu Gln Val Lys Ile Ala Val Asn Thr Ser
        515                 520                 525             
Lys Tyr Ala Glu Ser Tyr Arg Ile Gln Thr Tyr Ala Glu Tyr Met Gly
    530                 535                 540                 
Arg Lys Gln Glu Glu Lys Gln Ile Lys Arg Lys Trp Thr Glu Asp Ser
545                 550                 555                 560 
Trp Lys Glu Ala Asp Ser Lys Arg Leu Asn Pro Gln Cys Ile Pro Tyr
                565                 570                 575     
Thr Leu Gln Asn His Tyr Tyr Arg Asn Asn Ser Phe Thr Ala Pro Ser
            580                 585                 590         
Thr Val Gly Lys Arg Asn Leu Ser Pro Ser Gln Glu Glu Ala Gly Leu
        595                 600                 605             
Glu Asp Gly Val Ser Gly Glu Ile Ser Asp Thr Glu Leu Glu Gln Thr
    610                 615                 620                 
Asp Ser Cys Ala Glu Pro Leu Ser Glu Gly Arg Lys Lys Ala Lys Lys
625                 630                 635                 640 
Leu Lys Arg Met Lys Lys Glu Leu Ser Pro Ala Gly Ser Ile Ser Lys
                645                 650                 655     
Asn Ser Pro Ala Thr Leu Phe Glu Val Pro Asp Thr Trp
            660                 665                 


<210> 7226
<211> 1158
<212> PRT
<213> Homo sapiens

<400> 7226
Met Thr His Gly Glu Glu Leu Gly Ser Asp Val His Gln Asp Ser Ile
 1               5                  10                  15      
Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln Ala Ala Gly Gly
            20                  25                  30          
Ser Gly Thr Ala Val Asp Lys Lys Ser Ala Gly His Asn Glu Glu Asp
        35                  40                  45              
Gln Asn Phe Asn Ile Ser Gly Ser Ala Phe Pro Thr Cys Gln Ser Asn
    50                  55                  60                  
Gly Pro Val Leu Asn Thr His Thr Tyr Gln Gly Ser Gly Met Leu His
65                  70                  75                  80  
Leu Lys Lys Ala Arg Leu Leu Gln Ser Ser Glu Asp Trp Asn Ala Ala
                85                  90                  95      
Lys Arg Lys Arg Leu Ser Asp Ser Ile Met Asn Leu Asn Val Lys Lys
            100                 105                 110         
Glu Ala Leu Leu Ala Gly Met Val Asp Ser Val Pro Lys Gly Lys Gln
        115                 120                 125             
Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe Ser Ser Arg Leu
    130                 135                 140                 
Gln Thr Val Ala Leu Ser Gln Gln Ile Arg Gln Ser Leu Lys Glu Gln
145                 150                 155                 160 
Gly Tyr Ala Leu Ser His Asp Ser Leu Lys Val Glu Lys Asp Leu Arg
                165                 170                 175     
Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser
            180                 185                 190         
Lys Val Lys Asp Gln Lys Pro Asp Thr Asn Leu Pro Asp Val Thr Lys
        195                 200                 205             
Asn Leu Ile Arg Asp Arg Phe Ala Glu Ser Pro His His Val Gly Gln
    210                 215                 220                 
Ser Gly Thr Lys Val Met Ser Glu Pro Leu Ser Cys Ala Ala Arg Leu
225                 230                 235                 240 
Gln Ala Val Ala Ser Met Val Glu Lys Arg Ala Ser Pro Ala Thr Ser
                245                 250                 255     
Pro Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser
            260                 265                 270         
Glu Ala His Leu Gln Gln Tyr Ser Arg Glu His Ala Leu Lys Thr Gln
        275                 280                 285             
Asn Ala Asn Gln Ala Ala Ser Glu Arg Leu Ala Ala Met Ala Arg Leu
    290                 295                 300                 
Gln Glu Asn Gly Gln Lys Asp Val Gly Ser Tyr Gln Leu Pro Lys Gly
305                 310                 315                 320 
Met Ser Ser His Leu Asn Gly Gln Ala Arg Thr Ser Ser Ser Lys Leu
                325                 330                 335     
Met Ala Ser Lys Ser Ser Ala Thr Val Phe Gln Asn Pro Met Gly Ile
            340                 345                 350         
Ile Pro Ser Ser Pro Lys Asn Ala Gly Tyr Lys Asn Ser Leu Glu Arg
        355                 360                 365             
Asn Asn Ile Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu
    370                 375                 380                 
Lys Ser Gln Thr Ile Pro Lys Pro Met Asn Gly His Ser His Ser Glu
385                 390                 395                 400 
Arg Gly Ser Ile Phe Glu Glu Ser Ser Thr Pro Thr Thr Ile Asp Glu
                405                 410                 415     
Tyr Ser Asp Asn Asn Pro Ser Phe Thr Asp Asp Ser Ser Gly Asp Glu
            420                 425                 430         
Ser Ser Tyr Ser Asn Cys Val Pro Ile Asp Leu Ser Cys Lys His Arg
        435                 440                 445             
Thr Glu Lys Ser Glu Ser Asp Gln Pro Val Ser Leu Asp Asn Phe Thr
    450                 455                 460                 
Gln Ser Leu Leu Asn Thr Trp Asp Pro Lys Val Pro Asp Val Asp Ile
465                 470                 475                 480 
Lys Glu Asp Gln Asp Thr Ser Lys Asn Ser Lys Leu Asn Ser His Gln
                485                 490                 495     
Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys Asn Glu Glu Asn
            500                 505                 510         
Val Glu Lys Asn Thr Ser Pro Gln Gly Val His Asn Asp Val Ser Lys
        515                 520                 525             
Phe Asn Thr Gln Asn Tyr Ala Arg Thr Ser Val Ile Glu Ser Pro Ser
    530                 535                 540                 
Thr Asn Arg Thr Thr Pro Val Ser Thr Pro Pro Leu Leu Thr Ser Ser
545                 550                 555                 560 
Lys Ala Gly Ser Pro Ile Asn Leu Ser Gln His Ser Leu Val Ile Lys
                565                 570                 575     
Trp Asn Ser Pro Pro Tyr Val Cys Ser Thr Gln Ser Glu Lys Leu Thr
            580                 585                 590         
Asn Thr Ala Ser Asn His Ser Met Asp Leu Thr Lys Ser Lys Asp Pro
        595                 600                 605             
Pro Gly Glu Lys Pro Ala Gln Asn Glu Gly Ala Gln Asn Ser Ala Thr
    610                 615                 620                 
Phe Ser Ala Ser Lys Leu Leu Gln Asn Leu Ala Gln Cys Gly Met Gln
625                 630                 635                 640 
Ser Ser Met Ser Val Glu Glu Gln Arg Pro Ser Lys Gln Leu Leu Thr
                645                 650                 655     
Gly Asn Thr Asp Lys Pro Ile Gly Met Ile Asp Arg Leu Asn Ser Pro
            660                 665                 670         
Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala Phe Ser
        675                 680                 685             
Ser Gln Pro Thr Gly Pro Glu Pro Gly Leu Ser Gly Ser Glu Ile Glu
    690                 695                 700                 
Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro
705                 710                 715                 720 
Asn Lys Gly Lys Ser Glu Lys Lys Glu Lys Thr Pro Leu Arg Asp Glu
                725                 730                 735     
Ser Thr Gln Glu His Ser Glu Arg Ala Leu Ser Glu Gln Ile Leu Met
            740                 745                 750         
Val Lys Ile Lys Ser Glu Pro Cys Asp Asp Leu Gln Ile Pro Asn Thr
        755                 760                 765             
Asn Val His Leu Ser His Asp Ala Lys Ser Ala Pro Phe Leu Gly Met
    770                 775                 780                 
Ala Pro Ala Val Gln Arg Ser Ala Pro Ala Leu Pro Val Ser Glu Asp
785                 790                 795                 800 
Phe Lys Ser Glu Pro Val Ser Pro Gln Asp Phe Ser Phe Ser Lys Asn
                805                 810                 815     
Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn Gln Asp Ser Tyr Leu Ala
            820                 825                 830         
Asp Asp Ser Asp Arg Ser His Arg Asn Asn Glu Met Ala Leu Leu Glu
        835                 840                 845             
Ser Lys Asn Leu Cys Met Val Pro Lys Lys Arg Lys Leu Tyr Thr Glu
    850                 855                 860                 
Pro Leu Glu Asn Pro Phe Lys Lys Met Lys Asn Asn Ile Val Asp Ala
865                 870                 875                 880 
Ala Asn Asn His Ser Ala Pro Glu Val Leu Tyr Gly Ser Leu Leu Asn
                885                 890                 895     
Gln Glu Glu Leu Lys Phe Ser Arg Asn Asp Leu Glu Phe Lys Tyr Pro
            900                 905                 910         
Ala Gly His Gly Ser Ala Ser Glu Ser Glu His Arg Ser Trp Ala Arg
        915                 920                 925             
Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu Asn
    930                 935                 940                 
Cys Val Arg Asp Leu Ser Pro His Arg Ser Asn Ser Val Ala Asp Ser
945                 950                 955                 960 
Lys Lys Lys Gly His Lys Asn Asn Val Thr Asn Ser Lys Pro Glu Phe
                965                 970                 975     
Ser Ile Ser Ser Leu Asn Gly Leu Met Tyr Ser Ser Thr Gln Pro Ser
            980                 985                 990         
Ser Cys Met Asp Asn Arg Thr Phe Ser Tyr Pro Gly Val Val Lys Thr
        995                 1000                1005            
Pro Val Ser Pro Thr Phe Pro Glu His Leu Gly Cys Ala Gly Ser Arg
    1010                1015                1020                
Pro Glu Ser Gly Leu Leu Asn Gly Cys Ser Met Pro Ser Glu Lys Gly
1025                1030                1035                1040
Pro Ile Lys Trp Val Ile Thr Asp Ala Glu Lys Asn Glu Tyr Glu Lys
                1045                1050                1055    
Asp Ser Pro Arg Leu Thr Lys Thr Asn Pro Ile Leu Tyr Tyr Met Leu
            1060                1065                1070        
Gln Lys Gly Gly Asn Ser Val Thr Ser Arg Glu Thr Gln Asp Lys Asp
        1075                1080                1085            
Ile Trp Arg Glu Ala Ser Ser Ala Glu Ser Val Ser Gln Val Thr Ala
    1090                1095                1100                
Lys Glu Glu Leu Leu Pro Thr Ala Glu Thr Lys Ala Ser Phe Phe Asn
1105                1110                1115                1120
Leu Arg Ser Pro Tyr Asn Ser His Met Gly Asn Asn Ala Ser Arg Pro
                1125                1130                1135    
His Ser Ala Asn Gly Glu Val Tyr Gly Leu Leu Gly Ser Val Leu Thr
            1140                1145                1150        
Ile Lys Lys Glu Ser Glu
        1155            


<210> 7227
<211> 1734
<212> PRT
<213> Homo sapiens

<400> 7227
Met Lys Arg Ser Arg Cys Arg Asp Arg Pro Gln Pro Pro Pro Pro Asp
 1               5                  10                  15      
Arg Arg Glu Asp Gly Val Gln Arg Ala Ala Glu Leu Ser Gln Ser Leu
            20                  25                  30          
Pro Pro Arg Arg Arg Ala Pro Pro Gly Arg Gln Arg Leu Glu Glu Arg
        35                  40                  45              
Thr Gly Pro Ala Gly Pro Glu Gly Lys Glu Gln Asp Val Val Thr Gly
    50                  55                  60                  
Val Ser Pro Leu Leu Phe Arg Lys Leu Ser Asn Pro Asp Ile Phe Ser
65                  70                  75                  80  
Ser Thr Gly Lys Val Lys Leu Gln Arg Gln Leu Ser Gln Asp Asp Cys
                85                  90                  95      
Lys Leu Trp Arg Gly Asn Leu Ala Ser Ser Leu Ser Gly Lys Gln Leu
            100                 105                 110         
Leu Pro Leu Ser Ser Ser Val His Ser Ser Val Gly Gln Val Thr Trp
        115                 120                 125             
Gln Ser Ser Gly Glu Ala Ser Asn Leu Val Arg Met Arg Asn Gln Ser
    130                 135                 140                 
Leu Gly Gln Ser Ala Pro Ser Leu Thr Ala Gly Leu Lys Glu Leu Ser
145                 150                 155                 160 
Leu Pro Arg Arg Gly Ser Phe Cys Arg Thr Ser Asn Arg Lys Ser Leu
                165                 170                 175     
Ile Val Thr Ser Ser Thr Ser Pro Thr Leu Pro Arg Pro His Ser Pro
            180                 185                 190         
Leu His Gly His Thr Gly Asn Ser Pro Leu Asp Ser Pro Arg Asn Phe
        195                 200                 205             
Ser Pro Asn Ala Pro Ala His Phe Ser Phe Val Pro Ala Arg Arg Thr
    210                 215                 220                 
Asp Gly Arg Arg Trp Ser Leu Ala Ser Leu Pro Ser Ser Gly Tyr Gly
225                 230                 235                 240 
Thr Asn Thr Pro Ser Ser Thr Val Ser Ser Ser Cys Ser Ser Gln Glu
                245                 250                 255     
Lys Leu His Gln Leu Pro Phe Gln Pro Thr Ala Asp Glu Leu His Phe
            260                 265                 270         
Leu Thr Lys His Phe Ser Thr Glu Ser Val Pro Asp Glu Glu Gly Arg
        275                 280                 285             
Gln Ser Pro Ala Met Arg Pro Arg Ser Arg Ser Leu Ser Pro Gly Arg
    290                 295                 300                 
Ser Pro Val Ser Phe Asp Ser Glu Ile Ile Met Met Asn His Val Tyr
305                 310                 315                 320 
Lys Glu Arg Phe Pro Lys Ala Thr Ala Gln Met Glu Glu Arg Leu Ala
                325                 330                 335     
Glu Phe Ile Ser Ser Asn Thr Pro Asp Ser Val Leu Pro Leu Ala Asp
            340                 345                 350         
Gly Ala Leu Ser Phe Ile His His Gln Val Ile Glu Met Ala Arg Asp
        355                 360                 365             
Cys Leu Asp Lys Ser Arg Ser Gly Leu Ile Thr Ser Gln Tyr Phe Tyr
    370                 375                 380                 
Glu Leu Gln Glu Asn Leu Glu Lys Leu Leu Gln Asp Ala His Glu Arg
385                 390                 395                 400 
Ser Glu Ser Ser Glu Val Ala Phe Val Met Gln Leu Val Lys Lys Leu
                405                 410                 415     
Met Ile Ile Ile Ala Arg Pro Ala Arg Leu Leu Glu Cys Leu Glu Phe
            420                 425                 430         
Asp Pro Glu Glu Phe Tyr His Leu Leu Glu Ala Ala Glu Gly His Ala
        435                 440                 445             
Lys Glu Gly Gln Gly Ile Lys Cys Asp Ile Pro Arg Tyr Ile Val Ser
    450                 455                 460                 
Gln Leu Gly Leu Thr Arg Asp Pro Leu Glu Glu Met Ala Gln Leu Ser
465                 470                 475                 480 
Ser Cys Asp Ser Pro Asp Thr Pro Glu Thr Asp Asp Ser Ile Glu Gly
                485                 490                 495     
His Gly Ala Ser Leu Pro Ser Lys Lys Thr Pro Ser Glu Glu Asp Phe
            500                 505                 510         
Glu Thr Ile Lys Leu Ile Ser Asn Gly Ala Tyr Gly Ala Val Phe Leu
        515                 520                 525             
Val Arg His Lys Ser Thr Arg Gln Arg Phe Ala Met Lys Lys Ile Asn
    530                 535                 540                 
Lys Gln Asn Leu Ile Leu Arg Asn Gln Ile Gln Gln Ala Phe Val Glu
545                 550                 555                 560 
Arg Asp Ile Leu Thr Phe Ala Glu Asn Pro Phe Val Val Ser Met Phe
                565                 570                 575     
Cys Ser Phe Asp Thr Lys Arg His Leu Cys Met Val Met Glu Tyr Val
            580                 585                 590         
Glu Gly Gly Asp Cys Ala Thr Leu Leu Lys Asn Ile Gly Ala Leu Pro
        595                 600                 605             
Val Asp Met Val Arg Leu Tyr Phe Ala Glu Thr Val Leu Ala Leu Glu
    610                 615                 620                 
Tyr Leu His Asn Tyr Gly Ile Val His Arg Asp Leu Lys Pro Asp Asn
625                 630                 635                 640 
Leu Leu Ile Thr Ser Met Gly His Ile Lys Leu Thr Asp Phe Gly Leu
                645                 650                 655     
Ser Lys Met Gly Leu Met Ser Leu Thr Thr Asn Leu Tyr Glu Gly His
            660                 665                 670         
Ile Glu Lys Asp Ala Arg Glu Phe Leu Asp Lys Gln Val Cys Gly Thr
        675                 680                 685             
Pro Glu Tyr Ile Ala Pro Glu Val Ile Leu Arg Gln Gly Tyr Gly Lys
    690                 695                 700                 
Pro Val Asp Trp Trp Ala Met Gly Ile Ile Leu Tyr Glu Phe Leu Val
705                 710                 715                 720 
Gly Cys Val Pro Phe Phe Gly Asp Thr Pro Glu Glu Leu Phe Gly Gln
                725                 730                 735     
Val Ile Ser Asp Glu Ile Val Trp Pro Glu Gly Asp Glu Ala Leu Pro
            740                 745                 750         
Pro Asp Ala Gln Asp Leu Thr Ser Lys Leu Leu His Gln Asn Pro Leu
        755                 760                 765             
Glu Arg Leu Gly Thr Gly Ser Ala Tyr Glu Val Lys Gln His Pro Phe
    770                 775                 780                 
Phe Thr Gly Leu Asp Trp Thr Gly Leu Leu Arg Gln Lys Ala Glu Phe
785                 790                 795                 800 
Ile Pro Gln Leu Glu Ser Glu Asp Asp Thr Ser Tyr Phe Asp Thr Arg
                805                 810                 815     
Ser Glu Arg Tyr His His Met Asp Ser Glu Asp Glu Glu Glu Val Ser
            820                 825                 830         
Glu Asp Gly Cys Leu Glu Ile Arg Gln Phe Ser Ser Cys Ser Pro Arg
        835                 840                 845             
Phe Asn Lys Val Tyr Ser Ser Met Glu Arg Leu Ser Leu Leu Glu Glu
    850                 855                 860                 
Arg Arg Thr Pro Pro Pro Thr Lys Arg Ser Leu Ser Glu Glu Lys Glu
865                 870                 875                 880 
Asp His Ser Asp Gly Leu Ala Gly Leu Lys Gly Arg Asp Arg Ser Trp
                885                 890                 895     
Val Ile Gly Ser Pro Glu Ile Leu Arg Lys Arg Leu Ser Val Ser Glu
            900                 905                 910         
Ser Ser His Thr Glu Ser Asp Ser Ser Pro Pro Met Thr Val Arg Arg
        915                 920                 925             
Arg Cys Ser Gly Leu Leu Asp Ala Pro Arg Phe Pro Glu Gly Pro Glu
    930                 935                 940                 
Glu Ala Ser Ser Thr Leu Arg Arg Gln Pro Gln Glu Gly Ile Trp Val
945                 950                 955                 960 
Leu Thr Pro Pro Ser Gly Glu Gly Val Ser Gly Pro Val Thr Glu His
                965                 970                 975     
Ser Gly Glu Gln Arg Pro Lys Leu Asp Glu Glu Ala Val Gly Arg Ser
            980                 985                 990         
Ser Gly Ser Ser Pro Ala Met Glu Thr Arg Gly Arg Gly Thr Ser Gln
        995                 1000                1005            
Leu Ala Glu Gly Ala Thr Ala Lys Ala Ile Ser Asp Leu Ala Val Arg
    1010                1015                1020                
Arg Ala Arg His Arg Leu Leu Ser Gly Asp Ser Thr Glu Lys Arg Thr
1025                1030                1035                1040
Ala Arg Pro Val Asn Lys Val Ile Lys Ser Ala Ser Ala Thr Ala Leu
                1045                1050                1055    
Ser Leu Leu Ile Pro Ser Glu His His Thr Cys Ser Pro Leu Ala Ser
            1060                1065                1070        
Pro Met Ser Pro His Ser Gln Ser Ser Asn Pro Ser Ser Arg Asp Ser
        1075                1080                1085            
Ser Pro Ser Arg Asp Phe Leu Pro Ala Leu Gly Ser Met Arg Pro Pro
    1090                1095                1100                
Ile Ile Ile His Arg Ala Gly Lys Lys Tyr Gly Phe Thr Leu Arg Ala
1105                1110                1115                1120
Ile Arg Val Tyr Met Gly Asp Ser Asp Val Tyr Thr Val His His Met
                1125                1130                1135    
Val Trp His Val Glu Asp Gly Gly Pro Ala Ser Glu Ala Gly Leu Arg
            1140                1145                1150        
Gln Gly Asp Leu Ile Thr His Val Asn Gly Glu Pro Val His Gly Leu
        1155                1160                1165            
Val His Thr Glu Val Val Glu Leu Ile Leu Lys Ser Gly Asn Lys Val
    1170                1175                1180                
Ala Ile Ser Thr Thr Pro Leu Glu Asn Thr Ser Ile Lys Val Gly Pro
1185                1190                1195                1200
Ala Arg Lys Gly Ser Tyr Lys Ala Lys Met Ala Arg Arg Ser Lys Arg
                1205                1210                1215    
Ser Arg Gly Lys Asp Gly Gln Glu Ser Arg Lys Arg Ser Ser Leu Phe
            1220                1225                1230        
Arg Lys Ile Thr Lys Gln Ala Ser Leu Leu His Thr Ser Arg Ser Leu
        1235                1240                1245            
Ser Ser Leu Asn Arg Ser Leu Ser Ser Gly Glu Ser Gly Pro Gly Ser
    1250                1255                1260                
Pro Thr His Ser His Ser Leu Ser Pro Arg Ser Pro Thr Gln Gly Tyr
1265                1270                1275                1280
Arg Val Thr Pro Asp Ala Val His Ser Val Gly Gly Asn Ser Ser Gln
                1285                1290                1295    
Ser Ser Ser Pro Ser Ser Ser Val Pro Ser Ser Pro Ala Gly Ser Gly
            1300                1305                1310        
His Thr Arg Pro Ser Ser Leu His Gly Leu Ala Pro Lys Leu Gln Arg
        1315                1320                1325            
Gln Tyr Arg Ser Pro Arg Arg Lys Ser Ala Gly Ser Ile Pro Leu Ser
    1330                1335                1340                
Pro Leu Ala His Thr Pro Ser Pro Pro Pro Pro Thr Ala Ser Pro Gln
1345                1350                1355                1360
Arg Ser Pro Ser Pro Leu Ser Gly His Val Ala Gln Ala Phe Pro Thr
                1365                1370                1375    
Lys Leu His Leu Ser Pro Pro Leu Gly Arg Gln Leu Ser Arg Pro Lys
            1380                1385                1390        
Ser Ala Glu Pro Pro Arg Ser Pro Leu Leu Lys Arg Val Gln Ser Ala
        1395                1400                1405            
Glu Lys Leu Ala Ala Ala Leu Ala Ala Ser Glu Lys Lys Leu Ala Thr
    1410                1415                1420                
Ser Arg Lys His Ser Leu Asp Leu Pro His Ser Glu Leu Lys Lys Glu
1425                1430                1435                1440
Leu Pro Pro Arg Glu Val Ser Pro Leu Glu Val Val Gly Ala Arg Ser
                1445                1450                1455    
Val Leu Ser Gly Lys Gly Ala Leu Pro Gly Lys Gly Val Leu Gln Pro
            1460                1465                1470        
Ala Pro Ser Arg Ala Leu Gly Thr Leu Arg Gln Asp Arg Ala Glu Arg
        1475                1480                1485            
Arg Glu Ser Leu Gln Lys Gln Glu Ala Ile Arg Glu Val Asp Ser Ser
    1490                1495                1500                
Glu Asp Asp Thr Glu Glu Gly Pro Glu Asn Ser Gln Gly Ala Gln Glu
1505                1510                1515                1520
Leu Ser Leu Ala Pro His Pro Glu Val Ser Gln Ser Val Ala Pro Lys
                1525                1530                1535    
Gly Ala Gly Glu Ser Gly Glu Glu Asp Pro Phe Pro Ser Arg Gly Pro
            1540                1545                1550        
Arg Ser Leu Gly Pro Met Val Pro Ser Leu Leu Thr Gly Ile Thr Leu
        1555                1560                1565            
Gly Pro Pro Arg Met Glu Ser Pro Ser Gly Pro His Arg Arg Leu Gly
    1570                1575                1580                
Ser Pro Gln Ala Ile Glu Glu Ala Ala Ser Ser Ser Ser Ala Gly Pro
1585                1590                1595                1600
Asn Leu Gly Gln Ser Gly Ala Thr Asp Pro Ile Pro Pro Glu Gly Cys
                1605                1610                1615    
Trp Lys Ala Gln His Leu His Thr Gln Ala Leu Thr Ala Leu Ser Pro
            1620                1625                1630        
Ser Thr Ser Gly Leu Thr Pro Thr Ser Ser Cys Ser Pro Pro Ser Ser
        1635                1640                1645            
Thr Ser Gly Lys Leu Ser Met Trp Ser Trp Lys Ser Leu Ile Glu Gly
    1650                1655                1660                
Pro Asp Arg Ala Ser Pro Ser Arg Lys Ala Thr Met Ala Gly Gly Leu
1665                1670                1675                1680
Ala Asn Leu Gln Asp Leu Glu Thr Gln Leu Gln Pro Ser Leu Arg Thr
                1685                1690                1695    
Cys Leu Pro Gly Ser Arg Gly Arg His Ser His Leu Val Pro Pro Asp
            1700                1705                1710        
Trp Pro Ile His Leu Met Arg Ile Pro Ala Arg Ala Gly Tyr Gly Ser
        1715                1720                1725            
Leu Ser Val His Lys Gln
    1730                


<210> 7228
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 7228
Met Ala Ala Gly Gly Gly Gly Gly Ser Ser Lys Ala Ser Ser Ser Ser
 1               5                  10                  15      
Ala Ser Ser Ala Gly Ala Leu Glu Ser Ser Leu Asp Arg Lys Phe Gln
            20                  25                  30          
Ser Val Thr Asn Thr Met Glu Ser Ile Gln Gly Leu Ser Ser Trp Cys
        35                  40                  45              
Ile Glu Asn Lys Lys His His Ser Thr Ile Val Tyr His Trp Met Lys
    50                  55                  60                  
Trp Leu Arg Arg Ser Ala Tyr Pro His Arg Leu Asn Leu Phe Tyr Leu
65                  70                  75                  80  
Ala Asn Asp Val Ile Gln Asn Cys Lys Arg Lys Asn Ala Ile Ile Phe
                85                  90                  95      
Arg Glu Ser Phe Ala Asp Val Leu Pro Glu Ala Ala Ala Leu Val Lys
            100                 105                 110         
Asp Pro Ser Val Ser Lys Ser Val Glu Arg Ile Phe Lys Ile Trp Glu
        115                 120                 125             
Asp Arg Asn Val Tyr Pro Glu Glu Met Ile Val Ala Leu Arg Glu Ala
    130                 135                 140                 
Leu Ser Thr Thr Phe Lys Thr Gln Lys Gln Leu Lys Glu Asn Leu Asn
145                 150                 155                 160 
Lys Gln Pro Asn Lys Gln Trp Lys Lys Ser Gln Thr Ser Thr Asn Pro
                165                 170                 175     
Lys Ala Ala Leu Lys Ser Lys Ile Val Ala Glu Phe Arg Ser Gln Ala
            180                 185                 190         
Leu Ile Glu Glu Leu Leu Leu Tyr Lys Arg Ser Glu Asp Gln Ile Glu
        195                 200                 205             
Leu Lys Glu Lys Gln Leu Ser Thr Met Arg Val Asp Val Cys Ser Thr
    210                 215                 220                 
Glu Thr Leu Lys Cys Leu Lys Asp Lys Thr Gly Gly Lys Lys Phe Ser
225                 230                 235                 240 
Lys Glu Phe Glu Glu Ala Ser Ser Lys Leu Glu Glu Phe Val Asn Gly
                245                 250                 255     
Leu Asp Lys Gln Val Lys Asn Gly Pro Ser Leu Thr Glu Ala Leu Glu
            260                 265                 270         
Asn Ala Gly Ile Phe Tyr Glu Ala Gln Tyr Lys Glu Val Lys Val Val
        275                 280                 285             
Ala Asn Ala Tyr Lys Thr Phe Ala Asn Arg Val Asn Asn Leu Lys Lys
    290                 295                 300                 
Lys Leu Asp Gln Leu Lys Ser Thr Leu Pro Asp Pro Glu Glu Ser Pro
305                 310                 315                 320 
Val Pro Ser Pro Ser Met Asp Ala Pro Ser Pro Thr Gly Ser Glu Ser
                325                 330                 335     
Pro Phe Gln Gly Met Gly Gly Glu Glu Ser Gln Ser Pro Thr Met Glu
            340                 345                 350         
Ser Glu Lys Ser Ala Thr Pro Glu Pro Val Thr Asp Asn Arg Asp Val
        355                 360                 365             
Glu Asp Met Glu Leu Ser Asp Val Glu Asp Asp Gly Ser Lys Ile Ile
    370                 375                 380                 
Val Glu Asp Arg Lys Glu Lys Pro Ala Glu Lys Ser Ala Val Ser Thr
385                 390                 395                 400 
Ser Val Pro Thr Lys Pro Thr Glu Asn Ile Ser Lys Ala Ser Ser Cys
                405                 410                 415     
Thr Pro Val Pro Val Thr Met Thr Ala Thr Pro Pro Leu Pro Lys Pro
            420                 425                 430         
Val Asn Thr Ser Leu Ser Pro Ser Pro Ala Leu Ala Leu Pro Asn Leu
        435                 440                 445             
Ala Asn Val Asp Leu Ala Lys Ile Ser Ser Ile Leu Ser Ser Leu Thr
    450                 455                 460                 
Ser Val Met Lys Asn Thr Gly Val Ser Pro Ala Ser Arg Pro Ser Pro
465                 470                 475                 480 
Gly Thr Pro Thr Ser Pro Ser Asn Leu Thr Ser Gly Leu Lys Thr Pro
                485                 490                 495     
Ala Pro Ala Thr Thr Thr Ser His Asn Pro Leu Ala Asn Ile Leu Ser
            500                 505                 510         
Lys Val Glu Ile Thr Pro Glu Ser Ile Leu Ser Ala Leu Ser Lys Thr
        515                 520                 525             
Gln Thr Gln Ser Ala Pro Ala Leu Gln Gly Leu Ser Ser Leu Leu Gln
    530                 535                 540                 
Ser Val Thr Gly Asn Pro Val Pro Ala Ser Glu Ala Ala Ser Gln Ser
545                 550                 555                 560 
Thr Ser Ala Ser Pro Ala Asn Thr Thr Val Ser Thr Ile Lys Gly Arg
                565                 570                 575     
Asn Leu Pro Ser Ser Ala Gln Pro Phe Ile Pro Lys Ser Phe Asn Tyr
            580                 585                 590         
Ser Pro Asn Ser Ser Thr Ser Glu Val Ser Ser Thr Ser Ala Ser Lys
        595                 600                 605             
Ala Ser Ile Gly Gln Ser Pro Gly Leu Pro Ser Thr Thr Phe Lys Leu
    610                 615                 620                 
Pro Ser Asn Ser Leu Gly Phe Thr Ala Thr His Asn Thr Ser Pro Ala
625                 630                 635                 640 
Ala Pro Pro Thr Glu Val Thr Ile Cys Gln Ser Ser Glu Val Ser Lys
                645                 650                 655     
Pro Lys Leu Glu Ser Glu Ser Thr Ser Pro Ser Leu Glu Met Lys Ile
            660                 665                 670         
His Asn Phe Leu Lys Gly Asn Pro Gly Phe Ser Gly Leu Asn Leu Asn
        675                 680                 685             
Ile Pro Ile Leu Ser Ser Leu Gly Ser Ser Ala Pro Ser Glu Ser His
    690                 695                 700                 
Pro Ser Asp Phe Gln Arg Gly Pro Thr Ser Thr Ser Ile Asp Asn Ile
705                 710                 715                 720 
Asp Gly Thr Pro Val Arg Asp Glu Arg Ser Gly Thr Pro Thr Gln Asp
                725                 730                 735     
Glu Met Met Asp Lys Pro Thr Ser Ser Ser Val Asp Thr Met Ser Leu
            740                 745                 750         
Leu Ser Lys Ile Ile Ser Pro Gly Ser Ser Thr Pro Ser Ser Thr Arg
        755                 760                 765             
Ser Pro Pro Pro Gly Arg Asp Glu Ser Tyr Pro Arg Glu Leu Ser Asn
    770                 775                 780                 
Ser Val Ser Thr Tyr Arg Pro Phe Gly Leu Gly Ser Glu Ser Pro Tyr
785                 790                 795                 800 
Lys Gln Pro Ser Asp Gly Met Glu Arg Pro Ser Ser Leu Met Asp Ser
                805                 810                 815     
Ser Gln Glu Lys Phe Tyr Pro Asp Thr Ser Phe Gln Glu Asp Glu Asp
            820                 825                 830         
Tyr Arg Asp Phe Glu Tyr Ser Gly Pro Pro Pro Ser Ala Met Met Asn
        835                 840                 845             
Leu Glu Lys Lys Pro Ala Lys Ser Ile Leu Lys Ser Ser Lys Leu Ser
    850                 855                 860                 
Asp Thr Thr Glu Tyr Gln Pro Ile Leu Ser Ser Tyr Ser His Arg Ala
865                 870                 875                 880 
Gln Glu Phe Gly Val Lys Ser Ala Phe Pro Pro Ser Val Arg Ala Leu
                885                 890                 895     
Leu Asp Ser Ser Glu Asn Cys Asp Arg Leu Ser Ser Ser Pro Gly Leu
            900                 905                 910         
Phe Gly Ala Phe Ser Val Arg Gly Asn Glu Pro Gly Ser Asp Arg Ser
        915                 920                 925             
Pro Ser Pro Ser Lys Asn Asp Ser Phe Phe Thr Pro Asp Ser Asn His
    930                 935                 940                 
Asn Ser Leu Ser Gln Ser Thr Thr Gly His Leu Ser Leu Pro Gln Lys
945                 950                 955                 960 
Gln Tyr Pro Asp Ser Pro His Pro Val Pro His Arg Ser Leu Phe Ser
                965                 970                 975     
Pro Gln Asn Thr Leu Ala Ala Pro Thr Gly His Pro Pro Thr Ser Gly
            980                 985                 990         
Val Glu Lys Val Leu Ala Ser Thr Ile Ser Thr Thr Ser Thr Ile Glu
        995                 1000                1005            
Phe Lys Asn Met Leu Lys Asn Ala Ser Arg Lys Pro Ser Asp Asp Lys
    1010                1015                1020                
His Phe Gly Gln Ala Pro Ser Lys Gly Thr Pro Ser Asp Gly Val Ser
1025                1030                1035                1040
Leu Ser Asn Leu Thr Gln Pro Ser Leu Thr Ala Thr Asp Gln Gln Gln
                1045                1050                1055    
Gln Glu Glu His Tyr Arg Ile Glu Thr Arg Val Ser Ser Ser Cys Leu
            1060                1065                1070        
Asp Leu Pro Asp Ser Thr Glu Glu Lys Gly Ala Pro Ile Glu Thr Leu
        1075                1080                1085            
Gly Tyr His Ser Ala Ser Asn Arg Arg Met Ser Gly Glu Pro Ile Gln
    1090                1095                1100                
Thr Val Glu Ser Ile Arg Val Pro Gly Lys Gly Asn Arg Gly His Gly
1105                1110                1115                1120
Arg Glu Ala Ser Arg Val Gly Trp Phe Asp Leu Ser Thr Ser Gly Ser
                1125                1130                1135    
Ser Phe Asp Asn Gly Pro Ser Ser Ala Ser Glu Leu Ala Ser Leu Gly
            1140                1145                1150        
Gly Gly Gly Ser Gly Gly Leu Thr Gly Phe Lys Thr Ala Pro Tyr Lys
        1155                1160                1165            
Glu Arg Ala Pro Gln Phe Gln Glu Ser Val Gly Ser Phe Arg Ser Asn
    1170                1175                1180                
Ser Phe Asn Ser Thr Phe Glu His His Leu Pro Pro Ser Pro Leu Glu
1185                1190                1195                1200
His Gly Thr Pro Phe Gln Arg Glu Pro Val Gly Pro Ser Ser Ala Pro
                1205                1210                1215    
Pro Val Pro Pro Lys Asp His Gly Gly Ile Phe Ser Arg Asp Ala Pro
            1220                1225                1230        
Thr His Leu Pro Ser Val Asp Leu Ser Asn Pro Phe Thr Lys Glu Ala
        1235                1240                1245            
Ala Leu Ala His Ala Ala Pro Pro Pro Pro Pro Gly Glu His Ser Gly
    1250                1255                1260                
Ile Pro Phe Pro Thr Pro Pro Pro Pro Pro Pro Pro Gly Glu His Ser
1265                1270                1275                1280
Ser Ser Gly Gly Ser Gly Val Pro Phe Ser Thr Pro Pro Pro Pro Pro
                1285                1290                1295    
Pro Pro Val Asp His Ser Gly Val Val Pro Phe Pro Ala Pro Pro Leu
            1300                1305                1310        
Ala Glu His Gly Val Ala Gly Ala Val Ala Val Phe Pro Lys Asp His
        1315                1320                1325            
Ser Ser Leu Leu Gln Gly Thr Leu Ala Glu His Phe Gly Val Leu Pro
    1330                1335                1340                
Gly Pro Arg Asp His Gly Gly Pro Thr Gln Arg Asp Leu Asn Gly Pro
1345                1350                1355                1360
Gly Leu Ser Arg Val Arg Glu Ser Leu Thr Leu Pro Ser His Ser Leu
                1365                1370                1375    
Glu His Leu Gly Pro Pro His Gly Gly Gly Gly Gly Gly Gly Ser Asn
            1380                1385                1390        
Ser Ser Ser Gly Pro Pro Leu Gly Pro Ser His Arg Asp Thr Ile Ser
        1395                1400                1405            
Arg Ser Gly Ile Ile Leu Arg Ser Pro Arg Pro Asp Phe Arg Pro Arg
    1410                1415                1420                
Glu Pro Phe Leu Ser Arg Asp Pro Phe His Ser Leu Lys Arg Pro Arg
1425                1430                1435                1440
Pro Pro Phe Ala Arg Gly Pro Pro Phe Phe Ala Pro Lys Arg Pro Phe
                1445                1450                1455    
Phe Pro Pro Arg Tyr
            1460    


<210> 7229
<211> 1435
<212> PRT
<213> Homo sapiens

<400> 7229
Met Ala Ala Gly Gly Gly Gly Gly Ser Ser Lys Ala Ser Ser Ser Ser
 1               5                  10                  15      
Ala Ser Ser Ala Gly Ala Leu Glu Ser Ser Leu Asp Arg Lys Phe Gln
            20                  25                  30          
Ser Val Thr Asn Thr Met Glu Ser Ile Gln Gly Leu Ser Ser Trp Cys
        35                  40                  45              
Ile Glu Asn Lys Lys His His Ser Thr Ile Val Tyr His Trp Met Lys
    50                  55                  60                  
Trp Leu Arg Arg Ser Ala Tyr Pro His Arg Leu Asn Leu Phe Tyr Leu
65                  70                  75                  80  
Ala Asn Asp Val Ile Gln Asn Cys Lys Arg Lys Asn Ala Ile Ile Phe
                85                  90                  95      
Arg Glu Ser Phe Ala Asp Val Leu Pro Glu Ala Ala Ala Leu Val Lys
            100                 105                 110         
Asp Pro Ser Val Ser Lys Ser Val Glu Arg Ile Phe Lys Ile Trp Glu
        115                 120                 125             
Asp Arg Asn Val Tyr Pro Glu Glu Met Ile Val Ala Leu Arg Glu Ala
    130                 135                 140                 
Leu Thr Ser Thr Asn Pro Lys Ala Ala Leu Lys Ser Lys Ile Val Ala
145                 150                 155                 160 
Glu Phe Arg Ser Gln Ala Leu Ile Glu Glu Leu Leu Leu Tyr Lys Arg
                165                 170                 175     
Ser Glu Asp Gln Ile Glu Leu Lys Glu Lys Gln Leu Ser Thr Met Arg
            180                 185                 190         
Val Asp Val Cys Ser Thr Glu Thr Leu Lys Cys Leu Lys Asp Lys Thr
        195                 200                 205             
Gly Gly Lys Lys Phe Ser Lys Glu Phe Glu Glu Ala Ser Ser Lys Leu
    210                 215                 220                 
Glu Glu Phe Val Asn Gly Leu Asp Lys Gln Val Lys Asn Gly Pro Ser
225                 230                 235                 240 
Leu Thr Glu Ala Leu Glu Asn Ala Gly Ile Phe Tyr Glu Ala Gln Tyr
                245                 250                 255     
Lys Glu Val Lys Val Val Ala Asn Ala Tyr Lys Thr Phe Ala Asn Arg
            260                 265                 270         
Val Asn Asn Leu Lys Lys Lys Leu Asp Gln Leu Lys Ser Thr Leu Pro
        275                 280                 285             
Asp Pro Glu Glu Ser Pro Val Pro Ser Pro Ser Met Asp Ala Pro Ser
    290                 295                 300                 
Pro Thr Gly Ser Glu Ser Pro Phe Gln Gly Met Gly Gly Glu Glu Ser
305                 310                 315                 320 
Gln Ser Pro Thr Met Glu Ser Glu Lys Ser Ala Thr Pro Glu Pro Val
                325                 330                 335     
Thr Asp Asn Arg Asp Val Glu Asp Met Glu Leu Ser Asp Val Glu Asp
            340                 345                 350         
Asp Gly Ser Lys Ile Ile Val Glu Asp Arg Lys Glu Lys Pro Ala Glu
        355                 360                 365             
Lys Ser Ala Val Ser Thr Ser Val Pro Thr Lys Pro Thr Glu Asn Ile
    370                 375                 380                 
Ser Lys Ala Ser Ser Cys Thr Pro Val Pro Val Thr Met Thr Ala Thr
385                 390                 395                 400 
Pro Pro Leu Pro Lys Pro Val Asn Thr Ser Leu Ser Pro Ser Pro Ala
                405                 410                 415     
Leu Ala Leu Pro Asn Leu Ala Asn Val Asp Leu Ala Lys Ile Ser Ser
            420                 425                 430         
Ile Leu Ser Ser Leu Thr Ser Val Met Lys Asn Thr Gly Val Ser Pro
        435                 440                 445             
Ala Ser Arg Pro Ser Pro Gly Thr Pro Thr Ser Pro Ser Asn Leu Thr
    450                 455                 460                 
Ser Gly Leu Lys Thr Pro Ala Pro Ala Thr Thr Thr Ser His Asn Pro
465                 470                 475                 480 
Leu Ala Asn Ile Leu Ser Lys Val Glu Ile Thr Pro Glu Ser Ile Leu
                485                 490                 495     
Ser Ala Leu Ser Lys Thr Gln Thr Gln Ser Ala Pro Ala Leu Gln Gly
            500                 505                 510         
Leu Ser Ser Leu Leu Gln Ser Val Thr Gly Asn Pro Val Pro Ala Ser
        515                 520                 525             
Glu Ala Ala Ser Gln Ser Thr Ser Ala Ser Pro Ala Asn Thr Thr Val
    530                 535                 540                 
Ser Thr Ile Lys Gly Arg Asn Leu Pro Ser Ser Ala Gln Pro Phe Ile
545                 550                 555                 560 
Pro Lys Ser Phe Asn Tyr Ser Pro Asn Ser Ser Thr Ser Glu Val Ser
                565                 570                 575     
Ser Thr Ser Ala Ser Lys Ala Ser Ile Gly Gln Ser Pro Gly Leu Pro
            580                 585                 590         
Ser Thr Thr Phe Lys Leu Pro Ser Asn Ser Leu Gly Phe Thr Ala Thr
        595                 600                 605             
His Asn Thr Ser Pro Ala Ala Pro Pro Thr Glu Val Thr Ile Cys Gln
    610                 615                 620                 
Ser Ser Glu Val Ser Lys Pro Lys Leu Glu Ser Glu Ser Thr Ser Pro
625                 630                 635                 640 
Ser Leu Glu Met Lys Ile His Asn Phe Leu Lys Gly Asn Pro Gly Phe
                645                 650                 655     
Ser Gly Leu Asn Leu Asn Ile Pro Ile Leu Ser Ser Leu Gly Ser Ser
            660                 665                 670         
Ala Pro Ser Glu Ser His Pro Ser Asp Phe Gln Arg Gly Pro Thr Ser
        675                 680                 685             
Thr Ser Ile Asp Asn Ile Asp Gly Thr Pro Val Arg Asp Glu Arg Ser
    690                 695                 700                 
Gly Thr Pro Thr Gln Asp Glu Met Met Asp Lys Pro Thr Ser Ser Ser
705                 710                 715                 720 
Val Asp Thr Met Ser Leu Leu Ser Lys Ile Ile Ser Pro Gly Ser Ser
                725                 730                 735     
Thr Pro Ser Ser Thr Arg Ser Pro Pro Pro Gly Arg Asp Glu Ser Tyr
            740                 745                 750         
Pro Arg Glu Leu Ser Asn Ser Val Ser Thr Tyr Arg Pro Phe Gly Leu
        755                 760                 765             
Gly Ser Glu Ser Pro Tyr Lys Gln Pro Ser Asp Gly Met Glu Arg Pro
    770                 775                 780                 
Ser Ser Leu Met Asp Ser Ser Gln Glu Lys Phe Tyr Pro Asp Thr Ser
785                 790                 795                 800 
Phe Gln Glu Asp Glu Asp Tyr Arg Asp Phe Glu Tyr Ser Gly Pro Pro
                805                 810                 815     
Pro Ser Ala Met Met Asn Leu Glu Lys Lys Pro Ala Lys Ser Ile Leu
            820                 825                 830         
Lys Ser Ser Lys Leu Ser Asp Thr Thr Glu Tyr Gln Pro Ile Leu Ser
        835                 840                 845             
Ser Tyr Ser His Arg Ala Gln Glu Phe Gly Val Lys Ser Ala Phe Pro
    850                 855                 860                 
Pro Ser Val Arg Ala Leu Leu Asp Ser Ser Glu Asn Cys Asp Arg Leu
865                 870                 875                 880 
Ser Ser Ser Pro Gly Leu Phe Gly Ala Phe Ser Val Arg Gly Asn Glu
                885                 890                 895     
Pro Gly Ser Asp Arg Ser Pro Ser Pro Ser Lys Asn Asp Ser Phe Phe
            900                 905                 910         
Thr Pro Asp Ser Asn His Asn Ser Leu Ser Gln Ser Thr Thr Gly His
        915                 920                 925             
Leu Ser Leu Pro Gln Lys Gln Tyr Pro Asp Ser Pro His Pro Val Pro
    930                 935                 940                 
His Arg Ser Leu Phe Ser Pro Gln Asn Thr Leu Ala Ala Pro Thr Gly
945                 950                 955                 960 
His Pro Pro Thr Ser Gly Val Glu Lys Val Leu Ala Ser Thr Ile Ser
                965                 970                 975     
Thr Thr Ser Thr Ile Glu Phe Lys Asn Met Leu Lys Asn Ala Ser Arg
            980                 985                 990         
Lys Pro Ser Asp Asp Lys His Phe Gly Gln Ala Pro Ser Lys Gly Thr
        995                 1000                1005            
Pro Ser Asp Gly Val Ser Leu Ser Asn Leu Thr Gln Pro Ser Leu Thr
    1010                1015                1020                
Ala Thr Asp Gln Gln Gln Gln Glu Glu His Tyr Arg Ile Glu Thr Arg
1025                1030                1035                1040
Val Ser Ser Ser Cys Leu Asp Leu Pro Asp Ser Thr Glu Glu Lys Gly
                1045                1050                1055    
Ala Pro Ile Glu Thr Leu Gly Tyr His Ser Ala Ser Asn Arg Arg Met
            1060                1065                1070        
Ser Gly Glu Pro Ile Gln Thr Val Glu Ser Ile Arg Val Pro Gly Lys
        1075                1080                1085            
Gly Asn Arg Gly His Gly Arg Glu Ala Ser Arg Val Gly Trp Phe Asp
    1090                1095                1100                
Leu Ser Thr Ser Gly Ser Ser Phe Asp Asn Gly Pro Ser Ser Ala Ser
1105                1110                1115                1120
Glu Leu Ala Ser Leu Gly Gly Gly Gly Ser Gly Gly Leu Thr Gly Phe
                1125                1130                1135    
Lys Thr Ala Pro Tyr Lys Glu Arg Ala Pro Gln Phe Gln Glu Ser Val
            1140                1145                1150        
Gly Ser Phe Arg Ser Asn Ser Phe Asn Ser Thr Phe Glu His His Leu
        1155                1160                1165            
Pro Pro Ser Pro Leu Glu His Gly Thr Pro Phe Gln Arg Glu Pro Val
    1170                1175                1180                
Gly Pro Ser Ser Ala Pro Pro Val Pro Pro Lys Asp His Gly Gly Ile
1185                1190                1195                1200
Phe Ser Arg Asp Ala Pro Thr His Leu Pro Ser Val Asp Leu Ser Asn
                1205                1210                1215    
Pro Phe Thr Lys Glu Ala Ala Leu Ala His Ala Ala Pro Pro Pro Pro
            1220                1225                1230        
Pro Gly Glu His Ser Gly Ile Pro Phe Pro Thr Pro Pro Pro Pro Pro
        1235                1240                1245            
Pro Pro Gly Glu His Ser Ser Ser Gly Gly Ser Gly Val Pro Phe Ser
    1250                1255                1260                
Thr Pro Pro Pro Pro Pro Pro Pro Val Asp His Ser Gly Val Val Pro
1265                1270                1275                1280
Phe Pro Ala Pro Pro Leu Ala Glu His Gly Val Ala Gly Ala Val Ala
                1285                1290                1295    
Val Phe Pro Lys Asp His Ser Ser Leu Leu Gln Gly Thr Leu Ala Glu
            1300                1305                1310        
His Phe Gly Val Leu Pro Gly Pro Arg Asp His Gly Gly Pro Thr Gln
        1315                1320                1325            
Arg Asp Leu Asn Gly Pro Gly Leu Ser Arg Val Arg Glu Ser Leu Thr
    1330                1335                1340                
Leu Pro Ser His Ser Leu Glu His Leu Gly Pro Pro His Gly Gly Gly
1345                1350                1355                1360
Gly Gly Gly Gly Ser Asn Ser Ser Ser Gly Pro Pro Leu Gly Pro Ser
                1365                1370                1375    
His Arg Asp Thr Ile Ser Arg Ser Gly Ile Ile Leu Arg Ser Pro Arg
            1380                1385                1390        
Pro Asp Phe Arg Pro Arg Glu Pro Phe Leu Ser Arg Asp Pro Phe His
        1395                1400                1405            
Ser Leu Lys Arg Pro Arg Pro Pro Phe Ala Arg Gly Pro Pro Phe Phe
    1410                1415                1420                
Ala Pro Lys Arg Pro Phe Phe Pro Pro Arg Tyr
1425                1430                1435


<210> 7230
<211> 3485
<212> PRT
<213> Homo sapiens

<400> 7230
Met Ala Asn Arg Arg Val Gly Arg Gly Cys Trp Glu Val Ser Pro Thr
 1               5                  10                  15      
Glu Arg Arg Pro Pro Ala Gly Leu Arg Gly Pro Ala Ala Glu Glu Glu
            20                  25                  30          
Ala Ser Ser Pro Pro Val Leu Ser Leu Ser His Phe Cys Arg Ser Pro
        35                  40                  45              
Phe Leu Cys Phe Gly Asp Val Leu Leu Gly Ala Ser Arg Thr Leu Ser
    50                  55                  60                  
Leu Ala Leu Asp Asn Pro Asn Glu Glu Val Ala Glu Val Lys Ile Ser
65                  70                  75                  80  
His Phe Pro Ala Ala Asp Leu Gly Phe Ser Val Ser Gln Arg Cys Phe
                85                  90                  95      
Val Leu Gln Pro Lys Glu Lys Ile Val Ile Ser Val Asn Trp Thr Pro
            100                 105                 110         
Leu Lys Glu Gly Arg Val Arg Glu Ile Met Thr Phe Leu Val Asn Asp
        115                 120                 125             
Val Leu Lys His Gln Ala Ile Leu Leu Gly Asn Ala Glu Glu Gln Lys
    130                 135                 140                 
Lys Lys Lys Arg Ser Leu Trp Asp Thr Ile Lys Lys Lys Lys Ile Ser
145                 150                 155                 160 
Ala Ser Thr Ser His Asn Arg Arg Val Ser Asn Ile Gln Asn Val Asn
                165                 170                 175     
Lys Thr Phe Ser Val Ser Gln Lys Val Asp Arg Val Arg Ser Pro Leu
            180                 185                 190         
Gln Ala Cys Glu Asn Leu Ala Met Asn Glu Gly Gly Pro Pro Thr Glu
        195                 200                 205             
Asn Asn Ser Leu Ile Leu Glu Glu Asn Lys Ile Pro Ile Ser Pro Ile
    210                 215                 220                 
Ser Pro Ala Phe Asn Glu Cys His Gly Ala Thr Cys Leu Pro Leu Ser
225                 230                 235                 240 
Val Arg Arg Ser Thr Thr Tyr Ser Ser Leu His Ala Ser Glu Asn Arg
                245                 250                 255     
Glu Leu Leu Asn Val His Ser Ala Asn Val Ser Lys Val Ser Phe Asn
            260                 265                 270         
Glu Lys Ala Val Thr Glu Thr Ser Phe Asn Ser Val Asn Val Asn Gly
        275                 280                 285             
Gln Arg Gly Glu Asn Ser Lys Leu Ser Leu Thr Pro Asn Cys Ser Ser
    290                 295                 300                 
Thr Leu Asn Ile Thr Gln Ser Gln Ile His Phe Leu Ser Pro Asp Ser
305                 310                 315                 320 
Phe Val Asn Asn Ser His Gly Ala Asn Asn Glu Leu Glu Leu Val Thr
                325                 330                 335     
Cys Leu Ser Ser Asp Met Phe Met Lys Asp Asn Ser Gln Pro Val His
            340                 345                 350         
Leu Glu Ser Thr Ile Ala His Glu Ile Tyr Gln Lys Ile Leu Ser Pro
        355                 360                 365             
Asp Ser Phe Ile Lys Asp Asn Tyr Gly Leu Asn Gln Asp Leu Glu Ser
    370                 375                 380                 
Glu Ser Val Asn Pro Ile Leu Ser Pro Asn Gln Phe Leu Lys Asp Asn
385                 390                 395                 400 
Met Ala Tyr Met Cys Thr Ser Gln Gln Thr Cys Lys Val Pro Leu Ser
                405                 410                 415     
Asn Glu Asn Ser Gln Val Pro Gln Ser Pro Glu Asp Trp Arg Lys Ser
            420                 425                 430         
Glu Val Ser Pro Arg Ile Pro Glu Cys Gln Gly Ser Lys Ser Pro Lys
        435                 440                 445             
Ala Ile Phe Glu Glu Leu Val Glu Met Lys Ser Asn Tyr Tyr Ser Phe
    450                 455                 460                 
Ile Lys Gln Asn Asn Pro Lys Phe Ser Ala Val Gln Asp Ile Ser Ser
465                 470                 475                 480 
His Ser His Asn Lys Gln Pro Lys Arg Arg Pro Ile Leu Ser Ala Thr
                485                 490                 495     
Val Thr Lys Arg Lys Ala Thr Cys Thr Arg Glu Asn Gln Thr Glu Ile
            500                 505                 510         
Asn Lys Pro Lys Ala Lys Arg Cys Leu Asn Ser Ala Val Gly Glu His
        515                 520                 525             
Glu Lys Val Ile Asn Asn Gln Lys Glu Lys Glu Asp Phe His Ser Tyr
    530                 535                 540                 
Leu Pro Ile Ile Asp Pro Ile Leu Ser Lys Ser Lys Ser Tyr Lys Asn
545                 550                 555                 560 
Glu Val Thr Pro Ser Ser Thr Thr Ala Ser Val Ala Arg Lys Arg Lys
                565                 570                 575     
Ser Asp Gly Ser Met Glu Asp Ala Asn Val Arg Val Ala Ile Thr Glu
            580                 585                 590         
His Thr Glu Val Arg Glu Ile Lys Arg Ile His Phe Ser Pro Ser Glu
        595                 600                 605             
Pro Lys Thr Ser Ala Val Lys Lys Thr Lys Asn Val Thr Thr Pro Ile
    610                 615                 620                 
Ser Lys Arg Ile Ser Asn Arg Glu Lys Leu Asn Leu Lys Lys Lys Thr
625                 630                 635                 640 
Asp Leu Ser Ile Phe Arg Thr Pro Ile Ser Lys Thr Asn Lys Arg Thr
                645                 650                 655     
Lys Pro Ile Ile Ala Val Ala Gln Ser Ser Leu Thr Phe Ile Lys Pro
            660                 665                 670         
Leu Lys Thr Gly Asn Asn Leu Ile Val Phe Leu Asp Ile Pro Arg His
        675                 680                 685             
Pro Met Pro Phe Ala Ala Lys Asn Met Phe Tyr Asp Glu Arg Trp Lys
    690                 695                 700                 
Glu Lys Gln Glu Gln Gly Phe Thr Trp Trp Leu Asn Phe Ile Leu Thr
705                 710                 715                 720 
Pro Asp Asp Phe Thr Val Lys Thr Asn Ile Ser Glu Val Asn Ala Ala
                725                 730                 735     
Thr Leu Leu Leu Gly Ile Glu Asn Gln His Lys Ile Ser Val Pro Arg
            740                 745                 750         
Ala Pro Thr Lys Glu Glu Met Ser Leu Arg Ala Tyr Thr Ala Arg Cys
        755                 760                 765             
Arg Leu Asn Arg Leu Arg Arg Ala Ala Cys Arg Leu Phe Thr Ser Glu
    770                 775                 780                 
Lys Met Val Lys Ala Ile Lys Lys Leu Glu Ile Glu Ile Glu Ala Arg
785                 790                 795                 800 
Arg Leu Ile Val Arg Lys Asp Arg His Leu Trp Lys Asp Val Gly Glu
                805                 810                 815     
Arg Gln Lys Val Leu Asn Trp Leu Leu Ser Tyr Asn Pro Leu Trp Leu
            820                 825                 830         
Arg Ile Gly Leu Glu Thr Thr Tyr Gly Glu Leu Ile Ser Leu Glu Asp
        835                 840                 845             
Asn Ser Asp Val Thr Gly Leu Ala Met Phe Ile Leu Asn Arg Leu Leu
    850                 855                 860                 
Trp Asn Pro Asp Ile Ala Ala Glu Tyr Arg His Pro Thr Val Pro His
865                 870                 875                 880 
Leu Tyr Arg Asp Gly His Glu Glu Ala Leu Ser Lys Phe Thr Leu Lys
                885                 890                 895     
Lys Leu Leu Leu Leu Val Cys Phe Leu Asp Tyr Ala Lys Ile Ser Arg
            900                 905                 910         
Leu Ile Asp His Asp Pro Cys Leu Phe Cys Lys Asp Ala Glu Phe Lys
        915                 920                 925             
Ala Ser Lys Glu Ile Leu Leu Ala Phe Ser Arg Asp Phe Leu Ser Gly
    930                 935                 940                 
Glu Gly Asp Leu Ser Arg His Leu Gly Leu Leu Gly Leu Pro Val Asn
945                 950                 955                 960 
His Val Gln Thr Pro Phe Asp Glu Phe Asp Phe Ala Val Thr Asn Leu
                965                 970                 975     
Ala Val Asp Leu Gln Cys Gly Val Arg Leu Val Arg Thr Met Glu Leu
            980                 985                 990         
Leu Thr Gln Asn Trp Asp Leu Ser Lys Lys Leu Arg Ile Pro Ala Ile
        995                 1000                1005            
Ser Arg Leu Gln Lys Met His Asn Val Asp Ile Val Leu Gln Val Leu
    1010                1015                1020                
Lys Ser Arg Gly Ile Glu Leu Ser Asp Glu His Gly Asn Thr Ile Leu
1025                1030                1035                1040
Ser Lys Asp Ile Val Asp Arg His Arg Glu Lys Thr Leu Arg Leu Leu
                1045                1050                1055    
Trp Lys Ile Ala Phe Ala Phe Gln Val Asp Ile Ser Leu Asn Leu Asp
            1060                1065                1070        
Gln Leu Lys Glu Glu Ile Ala Phe Leu Lys His Thr Lys Ser Ile Lys
        1075                1080                1085            
Lys Thr Ile Ser Leu Leu Ser Cys His Ser Asp Asp Leu Ile Asn Lys
    1090                1095                1100                
Lys Lys Gly Lys Arg Asp Ser Gly Ser Phe Glu Gln Tyr Ser Glu Asn
1105                1110                1115                1120
Ile Lys Leu Leu Met Asp Trp Val Asn Ala Val Cys Ala Phe Tyr Asn
                1125                1130                1135    
Lys Lys Val Glu Asn Phe Thr Val Ser Phe Ser Asp Gly Arg Val Leu
            1140                1145                1150        
Cys Tyr Leu Ile His His Tyr His Pro Cys Tyr Val Pro Phe Asp Ala
        1155                1160                1165            
Ile Cys Gln Arg Thr Thr Gln Thr Val Glu Cys Thr Gln Thr Gly Ser
    1170                1175                1180                
Val Val Leu Asn Ser Ser Ser Glu Ser Asp Asp Ser Ser Leu Asp Met
1185                1190                1195                1200
Ser Leu Lys Ala Phe Asp His Glu Asn Thr Ser Glu Leu Tyr Lys Glu
                1205                1210                1215    
Leu Leu Glu Asn Glu Lys Lys Asn Phe His Leu Val Arg Ser Ala Val
            1220                1225                1230        
Arg Asp Leu Gly Gly Ile Pro Ala Met Ile Asn His Ser Asp Met Ser
        1235                1240                1245            
Asn Thr Ile Pro Asp Glu Lys Val Val Ile Thr Tyr Leu Ser Phe Leu
    1250                1255                1260                
Cys Ala Arg Leu Leu Asp Leu Arg Lys Glu Ile Arg Ala Ala Arg Leu
1265                1270                1275                1280
Ile Gln Thr Thr Trp Arg Lys Tyr Lys Leu Lys Thr Asp Leu Lys Arg
                1285                1290                1295    
His Gln Glu Arg Glu Lys Ala Ala Arg Ile Ile Gln Leu Ala Val Ile
            1300                1305                1310        
Asn Phe Leu Ala Lys Gln Arg Leu Arg Lys Arg Val Asn Ala Ala Leu
        1315                1320                1325            
Val Ile Gln Lys Tyr Trp Arg Arg Val Leu Ala Gln Arg Lys Leu Leu
    1330                1335                1340                
Met Leu Lys Lys Glu Lys Leu Glu Lys Val Gln Asn Lys Ala Ala Ser
1345                1350                1355                1360
Leu Ile Gln Gly Tyr Trp Arg Arg Tyr Ser Thr Arg Gln Arg Phe Leu
                1365                1370                1375    
Lys Leu Lys Tyr Tyr Ser Ile Ile Leu Gln Ser Arg Ile Arg Met Ile
            1380                1385                1390        
Ile Ala Val Thr Ser Tyr Lys Arg Tyr Leu Trp Ala Thr Val Thr Ile
        1395                1400                1405            
Gln Arg His Trp Arg Ala Tyr Leu Arg Arg Lys Gln Asp Gln Gln Arg
    1410                1415                1420                
Tyr Glu Met Leu Lys Ser Ser Thr Leu Ile Ile Gln Ser Met Phe Arg
1425                1430                1435                1440
Lys Trp Lys Gln Arg Lys Met Gln Ser Gln Val Lys Ala Thr Val Ile
                1445                1450                1455    
Leu Gln Arg Ala Phe Arg Glu Trp His Leu Arg Lys Gln Ala Lys Glu
            1460                1465                1470        
Glu Asn Ser Ala Ile Ile Ile Gln Ser Trp Tyr Arg Met His Lys Glu
        1475                1480                1485            
Leu Arg Lys Tyr Ile Tyr Ile Arg Ser Cys Val Val Ile Ile Gln Lys
    1490                1495                1500                
Arg Phe Arg Cys Phe Gln Ala Gln Lys Leu Tyr Lys Arg Arg Lys Glu
1505                1510                1515                1520
Ser Ile Leu Thr Ile Gln Lys Tyr Tyr Lys Ala Tyr Leu Lys Gly Lys
                1525                1530                1535    
Ile Glu Arg Thr Asn Tyr Leu Gln Lys Arg Ala Ala Ala Ile Gln Leu
            1540                1545                1550        
Gln Ala Ala Phe Arg Arg Leu Lys Ala His Asn Leu Cys Arg Gln Ile
        1555                1560                1565            
Arg Ala Ala Cys Val Ile Gln Ser Tyr Trp Arg Met Arg Gln Asp Arg
    1570                1575                1580                
Val Arg Phe Leu Asn Leu Lys Lys Thr Ile Ile Lys Phe Gln Ala His
1585                1590                1595                1600
Val Arg Lys His Gln Gln Arg Gln Lys Tyr Lys Lys Met Lys Lys Ala
                1605                1610                1615    
Ala Val Ile Ile Gln Thr His Phe Arg Ala Tyr Ile Phe Ala Met Lys
            1620                1625                1630        
Val Leu Ala Ser Tyr Gln Lys Thr Arg Ser Ala Val Ile Val Leu Gln
        1635                1640                1645            
Ser Ala Tyr Arg Gly Met Gln Ala Arg Lys Met Tyr Ile His Ile Leu
    1650                1655                1660                
Thr Ser Val Ile Lys Ile Gln Ser Tyr Tyr Arg Ala Tyr Val Ser Lys
1665                1670                1675                1680
Lys Glu Phe Leu Ser Leu Lys Asn Ala Thr Ile Lys Leu Gln Ser Thr
                1685                1690                1695    
Val Lys Met Lys Gln Thr Arg Lys Gln Tyr Leu His Leu Arg Ala Ala
            1700                1705                1710        
Ala Leu Phe Ile Gln Gln Cys Tyr Arg Ser Lys Lys Ile Ala Ala Gln
        1715                1720                1725            
Lys Arg Glu Glu Tyr Met Gln Met Arg Glu Ser Cys Ile Lys Leu Gln
    1730                1735                1740                
Ala Phe Val Arg Gly Tyr Leu Val Arg Lys Gln Met Arg Leu Gln Arg
1745                1750                1755                1760
Lys Ala Val Ile Ser Leu Gln Ser Tyr Phe Arg Met Arg Lys Ala Arg
                1765                1770                1775    
Gln Tyr Tyr Leu Lys Met Tyr Lys Ala Ile Ile Val Ile Gln Asn Tyr
            1780                1785                1790        
Tyr His Ala Tyr Lys Ala Gln Val Asn Gln Arg Lys Asn Phe Leu Gln
        1795                1800                1805            
Val Lys Lys Ala Ala Thr Cys Leu Gln Ala Ala Tyr Arg Gly Tyr Lys
    1810                1815                1820                
Val Arg Gln Leu Ile Lys Gln Gln Ser Ile Ala Ala Leu Lys Ile Gln
1825                1830                1835                1840
Ser Ala Phe Arg Gly Tyr Asn Lys Arg Val Lys Tyr Gln Ser Val Leu
                1845                1850                1855    
Gln Ser Ile Ile Lys Ile Gln Arg Trp Tyr Arg Ala Tyr Lys Thr Leu
            1860                1865                1870        
His Asp Thr Arg Thr His Phe Leu Lys Thr Lys Ala Ala Val Ile Ser
        1875                1880                1885            
Leu Gln Ser Ala Tyr Arg Gly Trp Lys Val Arg Lys Gln Ile Arg Arg
    1890                1895                1900                
Glu His Gln Ala Ala Leu Lys Ile Gln Ser Ala Phe Arg Met Ala Lys
1905                1910                1915                1920
Ala Gln Lys Gln Phe Arg Leu Phe Lys Thr Ala Ala Leu Val Ile Gln
                1925                1930                1935    
Gln Asn Phe Arg Ala Trp Thr Ala Gly Arg Lys Gln Cys Met Glu Tyr
            1940                1945                1950        
Ile Glu Leu Arg His Ala Val Leu Val Leu Gln Ser Met Trp Lys Gly
        1955                1960                1965            
Lys Thr Leu Arg Arg Gln Leu Gln Arg Gln His Lys Cys Ala Ile Ile
    1970                1975                1980                
Ile Gln Ser Tyr Tyr Arg Met His Val Gln Gln Lys Lys Trp Lys Ile
1985                1990                1995                2000
Met Lys Lys Ala Ala Leu Leu Ile Gln Lys Tyr Tyr Arg Ala Tyr Ser
                2005                2010                2015    
Ile Gly Arg Glu Gln Asn His Leu Tyr Leu Lys Thr Lys Ala Ala Val
            2020                2025                2030        
Val Thr Leu Gln Ser Ala Tyr Arg Gly Met Lys Val Arg Lys Arg Ile
        2035                2040                2045            
Lys Asp Cys Asn Lys Ala Ala Val Thr Ile Gln Ser Lys Tyr Arg Ala
    2050                2055                2060                
Tyr Lys Thr Lys Lys Lys Tyr Ala Thr Tyr Arg Ala Ser Ala Ile Ile
2065                2070                2075                2080
Ile Gln Arg Trp Tyr Arg Gly Ile Lys Ile Thr Asn His Gln His Lys
                2085                2090                2095    
Glu Tyr Leu Asn Leu Lys Lys Thr Ala Ile Lys Ile Gln Ser Val Tyr
            2100                2105                2110        
Arg Gly Ile Arg Val Arg Arg His Ile Gln His Met His Arg Ala Ala
        2115                2120                2125            
Thr Phe Ile Lys Ala Met Phe Lys Met His Gln Ser Arg Ile Ser Tyr
    2130                2135                2140                
His Thr Met Arg Lys Ala Ala Ile Val Ile Gln Val Arg Cys Arg Ala
2145                2150                2155                2160
Tyr Tyr Gln Gly Lys Met Gln Arg Glu Lys Tyr Leu Thr Ile Leu Lys
                2165                2170                2175    
Ala Val Lys Val Leu Gln Ala Ser Phe Arg Gly Val Arg Val Arg Arg
            2180                2185                2190        
Thr Leu Arg Lys Met Gln Thr Ala Ala Thr Leu Ile Gln Ser Asn Tyr
        2195                2200                2205            
Arg Arg Tyr Arg Gln Gln Thr Tyr Phe Asn Lys Leu Lys Lys Ile Thr
    2210                2215                2220                
Lys Thr Val Gln Gln Arg Tyr Trp Ala Met Lys Glu Arg Asn Ile Gln
2225                2230                2235                2240
Phe Gln Arg Tyr Asn Lys Leu Arg His Ser Val Ile Tyr Ile Gln Ala
                2245                2250                2255    
Ile Phe Arg Gly Lys Lys Ala Arg Arg His Leu Lys Met Met His Ile
            2260                2265                2270        
Ala Ala Thr Leu Ile Gln Arg Arg Phe Arg Thr Leu Met Met Arg Arg
        2275                2280                2285            
Arg Phe Leu Ser Leu Lys Lys Thr Ala Ile Leu Ile Gln Arg Lys Tyr
    2290                2295                2300                
Arg Ala His Leu Cys Thr Lys His His Leu Gln Phe Leu Gln Val Gln
2305                2310                2315                2320
Asn Ala Val Ile Lys Ile Gln Ser Ser Tyr Arg Arg Trp Met Ile Arg
                2325                2330                2335    
Lys Arg Met Arg Glu Met His Arg Ala Ala Thr Phe Ile Gln Ser Thr
            2340                2345                2350        
Phe Arg Met His Arg Leu His Met Arg Tyr Gln Ala Leu Lys Gln Ala
        2355                2360                2365            
Ser Val Val Ile Gln Gln Gln Tyr Gln Ala Asn Arg Ala Ala Lys Leu
    2370                2375                2380                
Gln Arg Gln His Tyr Leu Arg Gln Arg His Ser Ala Val Ile Leu Gln
2385                2390                2395                2400
Ala Ala Phe Arg Gly Met Lys Thr Arg Arg His Leu Lys Ser Met His
                2405                2410                2415    
Ser Ser Ala Thr Leu Ile Gln Ser Arg Phe Arg Ser Leu Leu Val Arg
            2420                2425                2430        
Arg Arg Phe Ile Ser Leu Lys Lys Ala Thr Ile Phe Val Gln Arg Lys
        2435                2440                2445            
Tyr Arg Ala Thr Ile Cys Ala Lys His Lys Leu Tyr Gln Phe Leu His
    2450                2455                2460                
Leu Arg Lys Ala Ala Ile Thr Ile Gln Ser Ser Tyr Arg Arg Leu Met
2465                2470                2475                2480
Val Lys Lys Lys Leu Gln Glu Met Gln Arg Ala Ala Val Leu Ile Gln
                2485                2490                2495    
Ala Thr Phe Arg Met Tyr Arg Thr Tyr Ile Thr Phe Gln Thr Trp Lys
            2500                2505                2510        
His Ala Ser Ile Leu Ile Gln Gln His Tyr Arg Thr Tyr Arg Ala Ala
        2515                2520                2525            
Lys Leu Gln Arg Glu Asn Tyr Ile Arg Gln Trp His Ser Ala Val Val
    2530                2535                2540                
Ile Gln Ala Ala Tyr Lys Gly Met Lys Ala Arg Gln Leu Leu Arg Glu
2545                2550                2555                2560
Lys His Lys Ala Ser Ile Val Ile Gln Ser Thr Tyr Arg Met Tyr Arg
                2565                2570                2575    
Gln Tyr Cys Phe Tyr Gln Lys Leu Gln Trp Ala Thr Lys Ile Ile Gln
            2580                2585                2590        
Glu Lys Tyr Arg Ala Asn Lys Lys Lys Gln Lys Val Phe Gln His Asn
        2595                2600                2605            
Glu Leu Lys Lys Glu Thr Cys Val Gln Ala Gly Phe Gln Asp Met Asn
    2610                2615                2620                
Ile Lys Lys Gln Ile Gln Glu Gln His Gln Ala Ala Ile Ile Ile Gln
2625                2630                2635                2640
Lys His Cys Lys Ala Phe Lys Ile Arg Lys His Tyr Leu His Leu Arg
                2645                2650                2655    
Ala Thr Val Val Ser Ile Gln Arg Arg Tyr Arg Lys Leu Thr Ala Val
            2660                2665                2670        
Arg Thr Gln Ala Val Ile Cys Ile Gln Ser Tyr Tyr Arg Gly Phe Lys
        2675                2680                2685            
Val Arg Lys Asp Ile Gln Asn Met His Arg Ala Ala Thr Leu Ile Gln
    2690                2695                2700                
Ser Phe Tyr Arg Met His Arg Ala Lys Val Asp Tyr Glu Thr Lys Lys
2705                2710                2715                2720
Thr Ala Ile Val Val Ile Gln Asn Tyr Tyr Arg Leu Tyr Val Arg Val
                2725                2730                2735    
Lys Thr Glu Arg Lys Asn Phe Leu Ala Val Gln Lys Ser Val Arg Thr
            2740                2745                2750        
Ile Gln Ala Ala Phe Arg Gly Met Lys Val Arg Gln Lys Leu Lys Asn
        2755                2760                2765            
Val Ser Glu Glu Lys Met Ala Ala Ile Val Asn Gln Ser Ala Leu Cys
    2770                2775                2780                
Cys Tyr Arg Ser Lys Thr Gln Tyr Glu Ala Val Gln Ser Glu Gly Val
2785                2790                2795                2800
Met Ile Gln Glu Trp Tyr Lys Ala Ser Gly Leu Ala Cys Ser Gln Glu
                2805                2810                2815    
Ala Glu Tyr His Ser Gln Ser Arg Ala Ala Val Thr Ile Gln Lys Ala
            2820                2825                2830        
Phe Cys Arg Met Val Thr Arg Lys Leu Glu Thr Gln Lys Cys Ala Ala
        2835                2840                2845            
Leu Arg Ile Gln Phe Phe Leu Gln Met Ala Val Tyr Arg Arg Arg Phe
    2850                2855                2860                
Val Gln Gln Lys Arg Ala Ala Ile Thr Leu Gln His Tyr Phe Arg Thr
2865                2870                2875                2880
Trp Gln Thr Arg Lys Gln Phe Leu Leu Tyr Arg Lys Ala Ala Val Val
                2885                2890                2895    
Leu Gln Asn His Tyr Arg Ala Phe Leu Ser Ala Lys His Gln Arg Gln
            2900                2905                2910        
Val Tyr Leu Gln Ile Arg Ser Ser Val Ile Ile Ile Gln Ala Arg Ser
        2915                2920                2925            
Lys Gly Phe Ile Gln Lys Arg Lys Phe Gln Glu Ile Lys Asn Ser Thr
    2930                2935                2940                
Ile Lys Ile Gln Ala Met Trp Arg Arg Tyr Arg Ala Lys Lys Tyr Leu
2945                2950                2955                2960
Cys Lys Val Lys Ala Ala Cys Lys Ile Gln Ala Trp Tyr Arg Cys Trp
                2965                2970                2975    
Arg Ala His Lys Glu Tyr Leu Ala Ile Leu Lys Ala Val Lys Ile Ile
            2980                2985                2990        
Gln Gly Cys Phe Tyr Thr Lys Leu Glu Arg Thr Arg Phe Leu Asn Val
        2995                3000                3005            
Arg Ala Ser Ala Ile Ile Ile Gln Arg Lys Trp Arg Ala Ile Leu Pro
    3010                3015                3020                
Ala Lys Ile Ala His Glu His Phe Leu Met Ile Lys Arg His Arg Ala
3025                3030                3035                3040
Ala Cys Leu Ile Gln Ala His Tyr Arg Gly Tyr Lys Gly Arg Gln Val
                3045                3050                3055    
Phe Leu Arg Gln Lys Ser Ala Ala Leu Ile Ile Gln Lys Tyr Ile Arg
            3060                3065                3070        
Ala Arg Glu Ala Gly Lys His Glu Arg Ile Lys Tyr Ile Glu Phe Lys
        3075                3080                3085            
Lys Ser Thr Val Ile Leu Gln Ala Leu Val Arg Gly Trp Leu Val Arg
    3090                3095                3100                
Lys Arg Phe Leu Glu Gln Arg Ala Lys Ile Arg Leu Leu His Phe Thr
3105                3110                3115                3120
Ala Ala Ala Tyr Tyr His Leu Asn Ala Val Arg Ile Gln Arg Ala Tyr
                3125                3130                3135    
Lys Leu Tyr Leu Ala Val Lys Asn Ala Asn Lys Gln Val Asn Ser Val
            3140                3145                3150        
Ile Cys Ile Gln Arg Trp Phe Arg Ala Arg Leu Gln Glu Lys Arg Phe
        3155                3160                3165            
Ile Gln Lys Tyr His Ser Ile Lys Lys Ile Glu His Glu Gly Gln Glu
    3170                3175                3180                
Cys Leu Ser Gln Arg Asn Arg Ala Ala Ser Val Ile Gln Lys Ala Val
3185                3190                3195                3200
Arg His Phe Leu Leu Arg Lys Lys Gln Glu Lys Phe Thr Ser Gly Ile
                3205                3210                3215    
Ile Lys Ile Gln Ala Leu Trp Arg Gly Tyr Ser Trp Arg Lys Lys Asn
            3220                3225                3230        
Asp Cys Thr Lys Ile Lys Ala Ile Arg Leu Ser Leu Gln Val Val Asn
        3235                3240                3245            
Arg Glu Ile Arg Glu Glu Asn Lys Leu Tyr Lys Arg Thr Ala Leu Ala
    3250                3255                3260                
Leu His Tyr Leu Leu Thr Tyr Lys His Leu Ser Ala Ile Leu Glu Ala
3265                3270                3275                3280
Leu Lys His Leu Glu Val Val Thr Arg Leu Ser Pro Leu Cys Cys Glu
                3285                3290                3295    
Asn Met Ala Gln Ser Gly Ala Ile Ser Lys Ile Phe Val Leu Ile Arg
            3300                3305                3310        
Ser Cys Asn Arg Ser Ile Pro Cys Met Glu Val Ile Arg Tyr Ala Val
        3315                3320                3325            
Gln Val Leu Leu Asn Val Ser Lys Tyr Glu Lys Thr Thr Ser Ala Val
    3330                3335                3340                
Tyr Asp Val Glu Asn Cys Ile Asp Ile Leu Leu Glu Leu Leu Gln Ile
3345                3350                3355                3360
Tyr Arg Glu Lys Pro Gly Asn Lys Val Ala Asp Lys Gly Gly Ser Ile
                3365                3370                3375    
Phe Thr Lys Thr Cys Cys Leu Leu Ala Ile Leu Leu Lys Thr Thr Asn
            3380                3385                3390        
Arg Ala Ser Asp Val Arg Ser Arg Ser Lys Val Val Asp Arg Ile Tyr
        3395                3400                3405            
Ser Leu Tyr Lys Leu Thr Ala His Lys His Lys Met Asn Thr Glu Arg
    3410                3415                3420                
Ile Leu Tyr Lys Gln Lys Lys Asn Ser Ser Ile Ser Ile Pro Phe Ile
3425                3430                3435                3440
Pro Glu Thr Pro Val Arg Thr Arg Ile Val Ser Arg Leu Lys Pro Asp
                3445                3450                3455    
Trp Val Leu Arg Arg Asp Asn Met Glu Glu Ile Thr Asn Pro Leu Gln
            3460                3465                3470        
Ala Ile Gln Met Val Met Asp Thr Leu Gly Ile Pro Tyr
        3475                3480                3485


<210> 7231
<211> 929
<212> PRT
<213> Homo sapiens

<400> 7231
Met Leu Gly Pro His Leu Pro Pro Pro Pro Leu Ala Pro Ser Glu Gly
 1               5                  10                  15      
Arg Pro Thr Pro Cys Ala Phe Gln Ile Pro Asp Gly Ser Tyr Arg Cys
            20                  25                  30          
Leu Ala Leu Glu Ala Glu Glu Ser Ser Gly Glu Glu Gly Leu Gln Gly
        35                  40                  45              
Glu Val Gly Pro Thr Asp Leu Glu Glu Asp Glu Gly Val Ser Arg Ser
    50                  55                  60                  
Gly Asp Asp Ser Ala Cys Arg Val Thr Gln Gly Thr Pro Gln Leu Pro
65                  70                  75                  80  
Lys Ala Leu Gly Ile Gln Pro Pro Ser Cys Ser Arg Glu Glu Arg Gly
                85                  90                  95      
Ala Ser Gln His Asp Asp Arg Ala Ser Gln Asp Trp Asp Val Val Lys
            100                 105                 110         
Ala Gly Gln Met Met Thr Ala Ser Pro Ser Pro Gly Pro Gly Pro Arg
        115                 120                 125             
Val Ala Gln Lys Pro Ala Leu Gly Arg Ser Thr Ser Leu Thr Glu Lys
    130                 135                 140                 
Asp Leu Lys Glu Ala Lys Ala Arg Ser Gln Gln Ile Ala Ala Gln Leu
145                 150                 155                 160 
Thr Thr Pro Pro Ser Ser Asn Ser Arg Gly Val Gln Leu Phe Asn Arg
                165                 170                 175     
Arg Arg Gln Arg Val Asn Glu Phe Thr Leu Glu Ser His Gly Gln Arg
            180                 185                 190         
Gly Gln Lys Pro Ser Gln Glu Ser Leu Arg Val Leu Pro Ser Ser Leu
        195                 200                 205             
Pro Gly His Ala Pro Gly Leu Ser Leu Ser Ser Thr Ser Leu Pro Glu
    210                 215                 220                 
Pro Gly Pro Pro Arg His Pro Ser Pro Gln Ser Pro Asp Arg Gly Val
225                 230                 235                 240 
Pro Gly His Ser Met Glu Gly Tyr Ser Glu Glu Ala Ser Leu Leu Arg
                245                 250                 255     
His Leu Glu Lys Val Ala Ser Glu Glu Glu Glu Val Pro Leu Val Val
            260                 265                 270         
Tyr Leu Lys Glu Asn Ala Ala Leu Leu Thr Ala Asn Gly Leu His Leu
        275                 280                 285             
Ser Gln Asn Arg Glu Ala Gln Gln Ser Ser Pro Ala Pro Pro Pro Ala
    290                 295                 300                 
Glu Val His Ser Pro Ala Ala Asp Val Asn Gln Asn Leu Ala Ser Pro
305                 310                 315                 320 
Ser Ala Thr Leu Thr Thr Pro Thr Ser Asn Ser Ser His Asn Pro Pro
                325                 330                 335     
Ala Thr Asp Val Asn Gln Asn Pro Pro Ala Thr Val Val Pro Gln Ser
            340                 345                 350         
Leu Pro Leu Ser Ser Ile Gln Gln Asn Ser Ser Glu Ala Gln Leu Pro
        355                 360                 365             
Ser Asn Gly Thr Gly Pro Ala Ser Lys Pro Ser Thr Leu Cys Ala Asp
    370                 375                 380                 
Gly Gln Pro Gln Ala Pro Ala Glu Glu Val Arg Cys Ser Thr Leu Leu
385                 390                 395                 400 
Ile Asp Lys Val Ser Thr Pro Ala Thr Thr Thr Ser Thr Phe Ser Arg
                405                 410                 415     
Glu Ala Thr Leu Ile Pro Ser Ser Arg Pro Pro Ala Ser Asp Phe Met
            420                 425                 430         
Ser Ser Ser Leu Leu Ile Asp Ile Gln Pro Asn Thr Leu Val Val Ser
        435                 440                 445             
Ala Asp Gln Glu Met Ser Gly Arg Ala Ala Ala Thr Thr Pro Thr Lys
    450                 455                 460                 
Val Tyr Ser Glu Val His Phe Thr Leu Ala Lys Pro Pro Ser Val Val
465                 470                 475                 480 
Asn Arg Thr Ala Arg Pro Phe Gly Ile Gln Ala Pro Gly Gly Thr Ser
                485                 490                 495     
Gln Met Glu Arg Ser Pro Met Leu Glu Arg Arg His Phe Gly Glu Lys
            500                 505                 510         
Ala Pro Ala Pro Gln Pro Pro Ser Leu Pro Asp Arg Ser Pro Arg Pro
        515                 520                 525             
Gln Arg His Ile Met Ser Arg Ser Pro Met Val Glu Arg Arg Met Met
    530                 535                 540                 
Gly Gln Arg Ser Pro Ala Ser Glu Arg Arg Pro Leu Gly Asn Phe Thr
545                 550                 555                 560 
Ala Pro Pro Thr Tyr Thr Glu Thr Leu Ser Thr Ala Pro Leu Ala Ser
                565                 570                 575     
Trp Val Arg Ser Pro Pro Ser Tyr Ser Val Leu Tyr Pro Ser Ser Asp
            580                 585                 590         
Pro Lys Ser Ser His Leu Lys Gly Gln Ala Val Pro Ala Ser Lys Thr
        595                 600                 605             
Gly Ile Leu Glu Glu Ser Met Ala Arg Arg Gly Ser Arg Lys Ser Met
    610                 615                 620                 
Phe Thr Phe Val Glu Lys Pro Lys Val Thr Pro Asn Pro Asp Leu Leu
625                 630                 635                 640 
Asp Leu Val Gln Thr Ala Asp Glu Lys Arg Arg Gln Arg Asp Gln Gly
                645                 650                 655     
Glu Val Gly Val Glu Glu Glu Pro Phe Ala Leu Gly Ala Glu Ala Ser
            660                 665                 670         
Asn Phe Gln Gln Glu Pro Ala Pro Arg Asp Arg Ala Ser Pro Ala Ala
        675                 680                 685             
Ala Glu Glu Val Val Pro Glu Trp Ala Ser Cys Leu Lys Ser Pro Arg
    690                 695                 700                 
Ile Gln Ala Lys Pro Lys Pro Lys Pro Asn Gln Asn Leu Ser Glu Ala
705                 710                 715                 720 
Ser Gly Lys Gly Ala Glu Leu Tyr Ala Arg Arg Gln Ser Arg Met Glu
                725                 730                 735     
Lys Tyr Val Ile Glu Ser Ser Ser His Thr Pro Glu Leu Ala Arg Cys
            740                 745                 750         
Pro Ser Pro Thr Met Ser Leu Pro Ser Ser Trp Lys Tyr Pro Thr Asn
        755                 760                 765             
Ala Pro Gly Ala Phe Arg Val Ala Ser Arg Ser Pro Ala Arg Thr Pro
    770                 775                 780                 
Pro Ala Ser Leu Tyr His Gly Tyr Leu Pro Glu Asn Gly Val Leu Arg
785                 790                 795                 800 
Pro Glu Pro Thr Lys Gln Pro Pro Tyr Gln Leu Arg Pro Ser Leu Phe
                805                 810                 815     
Val Leu Ser Pro Ile Lys Glu Pro Ala Lys Val Ser Pro Arg Ala Ala
            820                 825                 830         
Ser Pro Ala Lys Pro Ser Ser Leu Asp Leu Val Pro Asn Leu Pro Lys
        835                 840                 845             
Gly Ala Leu Pro Pro Ser Pro Ala Leu Pro Arg Pro Ser Arg Ser Ser
    850                 855                 860                 
Pro Gly Leu Tyr Thr Ser Pro Gly Gln Asp Ser Leu Gln Pro Thr Ala
865                 870                 875                 880 
Val Ser Pro Pro Tyr Gly Gly Asp Ile Ser Pro Val Ser Pro Ser Arg
                885                 890                 895     
Ala Trp Ser Pro Arg Ala Lys Gln Ala Pro Arg Pro Ser Phe Ser Thr
            900                 905                 910         
Arg Asn Ala Gly Ile Glu Ala Gln Val Trp Lys Pro Ser Phe Cys Phe
        915                 920                 925             
Lys
    


<210> 7232
<211> 903
<212> PRT
<213> Homo sapiens

<400> 7232
Met Glu Gly Tyr Ser Glu Glu Ala Ser Leu Leu Arg His Leu Glu Lys
 1               5                  10                  15      
Val Ala Ser Glu Glu Glu Glu Val Pro Leu Val Val Tyr Leu Lys Glu
            20                  25                  30          
Asn Ala Ala Leu Leu Thr Ala Asn Gly Leu His Leu Ser Gln Asn Arg
        35                  40                  45              
Glu Ala Gln Gln Ser Ser Pro Ala Pro Pro Pro Ala Glu Val His Ser
    50                  55                  60                  
Pro Ala Ala Asp Val Asn Gln Asn Leu Ala Ser Pro Ser Ala Thr Leu
65                  70                  75                  80  
Thr Thr Pro Thr Ser Asn Ser Ser His Asn Pro Pro Ala Thr Asp Val
                85                  90                  95      
Asn Gln Asn Pro Pro Ala Thr Val Val Pro Gln Ser Leu Pro Leu Ser
            100                 105                 110         
Ser Ile Gln Gln Asn Ser Ser Glu Ala Gln Leu Pro Ser Asn Gly Thr
        115                 120                 125             
Gly Pro Ala Ser Lys Pro Ser Thr Leu Cys Ala Asp Gly Gln Pro Gln
    130                 135                 140                 
Ala Pro Ala Glu Glu Val Arg Cys Ser Thr Leu Leu Ile Asp Lys Val
145                 150                 155                 160 
Ser Thr Pro Ala Thr Thr Thr Ser Thr Phe Ser Arg Glu Ala Thr Leu
                165                 170                 175     
Ile Pro Ser Ser Arg Pro Pro Ala Ser Asp Phe Met Ser Ser Ser Leu
            180                 185                 190         
Leu Ile Asp Ile Gln Pro Asn Thr Leu Val Val Ser Ala Asp Gln Glu
        195                 200                 205             
Met Ser Gly Arg Ala Ala Ala Thr Thr Pro Thr Lys Val Tyr Ser Glu
    210                 215                 220                 
Val His Phe Thr Leu Ala Lys Pro Pro Ser Val Val Asn Arg Thr Ala
225                 230                 235                 240 
Arg Pro Phe Gly Ile Gln Ala Pro Gly Gly Thr Ser Gln Met Glu Arg
                245                 250                 255     
Ser Pro Met Leu Glu Arg Arg His Phe Gly Glu Lys Ala Pro Ala Pro
            260                 265                 270         
Gln Pro Pro Ser Leu Pro Asp Arg Ser Pro Arg Pro Gln Arg His Ile
        275                 280                 285             
Met Ser Arg Ser Pro Met Val Glu Arg Arg Met Met Gly Gln Arg Ser
    290                 295                 300                 
Pro Ala Ser Glu Arg Arg Pro Leu Gly Asn Phe Thr Ala Pro Pro Thr
305                 310                 315                 320 
Tyr Thr Glu Thr Leu Ser Thr Ala Pro Leu Ala Ser Trp Val Arg Ser
                325                 330                 335     
Pro Pro Ser Tyr Ser Val Leu Tyr Pro Ser Ser Asp Pro Lys Ser Ser
            340                 345                 350         
His Leu Lys Gly Gln Ala Val Pro Ala Ser Lys Thr Gly Ile Leu Glu
        355                 360                 365             
Glu Ser Met Ala Arg Arg Gly Ser Arg Lys Ser Met Phe Thr Phe Val
    370                 375                 380                 
Glu Lys Pro Lys Val Thr Pro Asn Pro Asp Leu Leu Asp Leu Val Gln
385                 390                 395                 400 
Thr Ala Asp Glu Lys Arg Arg Gln Arg Asp Gln Gly Glu Val Gly Val
                405                 410                 415     
Glu Glu Glu Pro Phe Ala Leu Gly Ala Glu Ala Ser Asn Phe Gln Gln
            420                 425                 430         
Glu Pro Ala Pro Arg Asp Arg Ala Ser Pro Ala Ala Ala Glu Glu Val
        435                 440                 445             
Val Pro Glu Trp Ala Ser Cys Leu Lys Ser Pro Arg Ile Gln Ala Lys
    450                 455                 460                 
Pro Lys Pro Lys Pro Asn Gln Asn Leu Ser Glu Ala Ser Gly Lys Gly
465                 470                 475                 480 
Ala Glu Leu Tyr Ala Arg Arg Gln Ser Arg Met Glu Lys Tyr Val Ile
                485                 490                 495     
Glu Ser Ser Ser His Thr Pro Glu Leu Ala Arg Cys Pro Ser Pro Thr
            500                 505                 510         
Met Ser Leu Pro Ser Ser Trp Lys Tyr Pro Thr Asn Ala Pro Gly Ala
        515                 520                 525             
Phe Arg Val Ala Ser Arg Ser Pro Ala Arg Thr Pro Pro Ala Ser Leu
    530                 535                 540                 
Tyr His Gly Tyr Leu Pro Glu Asn Gly Val Leu Arg Pro Glu Pro Thr
545                 550                 555                 560 
Lys Gln Pro Pro Tyr Gln Leu Arg Pro Ser Leu Phe Val Leu Ser Pro
                565                 570                 575     
Ile Lys Glu Pro Ala Lys Val Ser Pro Arg Ala Ala Ser Pro Ala Lys
            580                 585                 590         
Pro Ser Ser Leu Asp Leu Val Pro Asn Leu Pro Lys Gly Ala Leu Pro
        595                 600                 605             
Pro Ser Pro Ala Leu Pro Arg Pro Ser Arg Ser Ser Pro Gly Leu Tyr
    610                 615                 620                 
Thr Ser Pro Gly Gln Asp Ser Leu Gln Pro Thr Ala Val Ser Pro Pro
625                 630                 635                 640 
Tyr Gly Gly Asp Ile Ser Pro Val Ser Pro Ser Arg Ala Trp Ser Pro
                645                 650                 655     
Arg Ala Lys Gln Ala Pro Arg Pro Ser Phe Ser Thr Arg Asn Ala Gly
            660                 665                 670         
Ile Glu Ala Gln Asp Arg Arg Glu Ser Leu Pro Thr Ser Pro Pro Trp
        675                 680                 685             
Thr Pro Gly Ala Ser Arg Pro Pro Ser Ser Leu Asp Gly Trp Val Ser
    690                 695                 700                 
Pro Gly Pro Trp Glu Pro Gly Arg Gly Ser Ser Met Ser Ser Pro Pro
705                 710                 715                 720 
Pro Leu Pro Pro Pro Pro Pro Met Ser Pro Ser Trp Ser Glu Arg Ser
                725                 730                 735     
Val Ser Pro Leu Arg Pro Glu Thr Glu Ala Arg Pro Pro Ser Arg Gln
            740                 745                 750         
Leu Gln Ala Leu Leu Ala Arg Asn Ile Ile Asn Ala Ala Arg Arg Lys
        755                 760                 765             
Ser Ala Ser Pro Arg Ser Ala Gly Ala Glu Asn Pro Arg Pro Phe Ser
    770                 775                 780                 
Pro Pro Arg Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
785                 790                 795                 800 
Arg Met Arg Ser Pro Gln Pro Ala Arg Pro Gly Ser Ala Ala Val Pro
                805                 810                 815     
Gly Ala Ala Phe Ala Pro Ile Pro Arg Ser Pro Leu Pro Ala Gly Pro
            820                 825                 830         
Ser Ser Cys Thr Ser Pro Arg Ser Pro Leu Pro Ala Pro Pro Arg Pro
        835                 840                 845             
Phe Leu Tyr Arg Arg Ser Pro Thr Asp Ser Asp Val Ser Leu Asp Ser
    850                 855                 860                 
Glu Asp Ser Gly Ala Lys Ser Pro Gly Ile Leu Gly Tyr Asn Ile Cys
865                 870                 875                 880 
Pro Arg Gly Trp Asn Gly Ser Leu Arg Leu Lys Arg Gly Ser Leu Pro
                885                 890                 895     
Ala Glu Ala Ser Cys Thr Thr
            900             


<210> 7233
<211> 979
<212> PRT
<213> Homo sapiens

<400> 7233
Met Ala Glu Ser Asp Ser Thr Asp Phe Asp Leu Leu Trp Tyr Leu Glu
 1               5                  10                  15      
Asn Leu Ser Asp Lys Glu Phe Gln Ser Phe Lys Lys Tyr Leu Ala Arg
            20                  25                  30          
Lys Ile Leu Asp Phe Lys Leu Pro Gln Phe Pro Leu Ile Gln Met Thr
        35                  40                  45              
Lys Glu Glu Leu Ala Asn Val Leu Pro Ile Ser Tyr Glu Gly Gln Tyr
    50                  55                  60                  
Ile Trp Asn Met Leu Phe Ser Ile Phe Ser Met Met Arg Lys Glu Asp
65                  70                  75                  80  
Leu Cys Arg Lys Ile Ile Gly Arg Arg Asn Arg Asn Gln Glu Ala Cys
                85                  90                  95      
Lys Ala Val Met Arg Arg Lys Phe Met Leu Gln Trp Glu Ser His Thr
            100                 105                 110         
Phe Gly Lys Phe His Tyr Lys Phe Phe Arg Asp Val Ser Ser Asp Val
        115                 120                 125             
Phe Tyr Ile Leu Gln Leu Ala Tyr Asp Ser Thr Ser Tyr Tyr Ser Ala
    130                 135                 140                 
Asn Asn Leu Asn Val Phe Leu Met Gly Glu Arg Ala Ser Gly Lys Thr
145                 150                 155                 160 
Ile Val Ile Asn Leu Ala Val Leu Arg Trp Ile Lys Gly Glu Met Trp
                165                 170                 175     
Gln Asn Met Ile Ser Tyr Val Val His Leu Thr Ser His Glu Ile Asn
            180                 185                 190         
Gln Met Thr Asn Ser Ser Leu Ala Glu Leu Ile Ala Lys Asp Trp Pro
        195                 200                 205             
Asp Gly Gln Ala Pro Ile Ala Asp Ile Leu Ser Asp Pro Lys Lys Leu
    210                 215                 220                 
Leu Phe Ile Leu Glu Asp Leu Asp Asn Ile Arg Phe Glu Leu Asn Val
225                 230                 235                 240 
Asn Glu Ser Ala Leu Cys Ser Asn Ser Thr Gln Lys Val Pro Ile Pro
                245                 250                 255     
Val Leu Leu Val Ser Leu Leu Lys Arg Lys Met Ala Pro Gly Cys Trp
            260                 265                 270         
Phe Leu Ile Ser Ser Arg Pro Thr Arg Gly Asn Asn Val Lys Thr Phe
        275                 280                 285             
Leu Lys Glu Val Asp Cys Cys Thr Thr Leu Gln Leu Ser Asn Gly Lys
    290                 295                 300                 
Arg Glu Ile Tyr Phe Asn Ser Phe Phe Lys Asp Arg Gln Arg Ala Ser
305                 310                 315                 320 
Ala Ala Leu Gln Leu Val His Glu Asp Glu Ile Leu Val Gly Leu Cys
                325                 330                 335     
Arg Val Ala Ile Leu Cys Trp Ile Thr Cys Thr Val Leu Lys Arg Gln
            340                 345                 350         
Met Asp Lys Gly Arg Asp Phe Gln Leu Cys Cys Gln Thr Pro Thr Asp
        355                 360                 365             
Leu His Ala His Phe Leu Ala Asp Ala Leu Thr Ser Glu Ala Gly Leu
    370                 375                 380                 
Thr Ala Asn Gln Tyr His Leu Gly Leu Leu Lys Arg Leu Cys Leu Leu
385                 390                 395                 400 
Ala Ala Gly Gly Leu Phe Leu Ser Thr Leu Asn Phe Ser Gly Glu Asp
                405                 410                 415     
Leu Arg Cys Val Gly Phe Thr Glu Ala Asp Val Ser Val Leu Gln Ala
            420                 425                 430         
Ala Asn Ile Leu Leu Pro Ser Asn Thr His Lys Asp Arg Tyr Lys Phe
        435                 440                 445             
Ile His Leu Asn Val Gln Glu Phe Cys Thr Ala Ile Ala Phe Leu Met
    450                 455                 460                 
Ala Val Pro Asn Tyr Leu Ile Pro Ser Gly Ser Arg Glu Tyr Lys Glu
465                 470                 475                 480 
Lys Arg Glu Gln Tyr Ser Asp Phe Asn Gln Val Phe Thr Phe Ile Phe
                485                 490                 495     
Gly Leu Leu Asn Ala Asn Arg Arg Lys Ile Leu Glu Thr Ser Phe Gly
            500                 505                 510         
Tyr Gln Leu Pro Met Val Asp Ser Phe Lys Trp Tyr Ser Val Gly Tyr
        515                 520                 525             
Met Lys His Leu Asp Arg Asp Pro Glu Lys Leu Thr His His Met Pro
    530                 535                 540                 
Leu Phe Tyr Cys Leu Tyr Glu Asn Arg Glu Glu Glu Phe Val Lys Thr
545                 550                 555                 560 
Ile Val Asp Ala Leu Met Glu Val Thr Val Tyr Leu Gln Ser Asp Lys
                565                 570                 575     
Asp Met Met Val Ser Leu Tyr Cys Leu Asp Tyr Cys Cys His Leu Arg
            580                 585                 590         
Thr Leu Lys Leu Ser Val Gln Arg Ile Phe Gln Asn Lys Glu Pro Leu
        595                 600                 605             
Ile Arg Pro Thr Ala Arg Leu Ser Tyr Val Ser Thr Ala Ser Gly Phe
    610                 615                 620                 
Glu Asp Leu Leu Lys Ala Leu Ala Arg Asn Arg Ser Leu Thr Tyr Leu
625                 630                 635                 640 
Ser Ile Asn Cys Thr Ser Ile Ser Leu Asn Met Phe Ser Leu Leu His
                645                 650                 655     
Asp Ile Leu His Glu Pro Thr Cys Gln Ile Ser His Leu Ser Leu Met
            660                 665                 670         
Lys Cys Asp Leu Arg Ala Ser Glu Cys Glu Glu Ile Ala Ser Leu Leu
        675                 680                 685             
Ile Ser Gly Gly Ser Leu Arg Lys Leu Thr Leu Ser Ser Asn Pro Leu
    690                 695                 700                 
Arg Ser Asp Gly Met Asn Ile Leu Cys Asp Ala Leu Leu His Pro Asn
705                 710                 715                 720 
Cys Thr Leu Ile Ser Leu Val Leu Val Phe Cys Cys Leu Thr Glu Asn
                725                 730                 735     
Cys Cys Ser Ala Leu Gly Arg Val Leu Leu Phe Ser Pro Thr Leu Arg
            740                 745                 750         
Gln Leu Asp Leu Cys Val Asn Arg Leu Lys Asn Tyr Gly Val Leu His
        755                 760                 765             
Val Thr Phe Pro Leu Leu Phe Pro Thr Cys Gln Leu Glu Glu Leu His
    770                 775                 780                 
Leu Ser Gly Cys Phe Phe Ser Ser Asp Ile Cys Gln Tyr Ile Ala Ile
785                 790                 795                 800 
Val Ile Ala Thr Asn Glu Lys Leu Arg Ser Leu Glu Ile Gly Ser Asn
                805                 810                 815     
Lys Ile Glu Asp Ala Gly Met Gln Leu Leu Cys Gly Gly Leu Arg His
            820                 825                 830         
Pro Asn Cys Met Leu Val Asn Ile Gly Leu Glu Glu Cys Met Leu Thr
        835                 840                 845             
Ser Ala Cys Cys Arg Ser Leu Ala Ser Val Leu Thr Thr Asn Lys Thr
    850                 855                 860                 
Leu Glu Arg Leu Asn Leu Leu Gln Asn His Leu Gly Asn Asp Gly Val
865                 870                 875                 880 
Ala Lys Leu Leu Glu Ser Leu Ile Ser Pro Asp Cys Val Leu Lys Val
                885                 890                 895     
Val Gly Leu Pro Leu Thr Gly Leu Asn Thr Gln Thr Gln Gln Leu Leu
            900                 905                 910         
Met Thr Val Lys Glu Arg Lys Pro Ser Leu Ile Phe Leu Ser Glu Thr
        915                 920                 925             
Trp Ser Leu Lys Glu Gly Arg Glu Ile Gly Val Thr Pro Ala Ser Gln
    930                 935                 940                 
Pro Gly Ser Ile Ile Pro Asn Ser Asn Leu Asp Tyr Met Phe Phe Lys
945                 950                 955                 960 
Phe Pro Arg Met Ser Ala Ala Met Arg Thr Ser Asn Thr Ala Ser Arg
                965                 970                 975     
Gln Pro Leu
            


<210> 7234
<211> 1033
<212> PRT
<213> Homo sapiens

<400> 7234
Met Ala Glu Ser Asp Ser Thr Asp Phe Asp Leu Leu Trp Tyr Leu Glu
 1               5                  10                  15      
Asn Leu Ser Asp Lys Glu Phe Gln Ser Phe Lys Lys Tyr Leu Ala Arg
            20                  25                  30          
Lys Ile Leu Asp Phe Lys Leu Pro Gln Phe Pro Leu Ile Gln Met Thr
        35                  40                  45              
Lys Glu Glu Leu Ala Asn Val Leu Pro Ile Ser Tyr Glu Gly Gln Tyr
    50                  55                  60                  
Ile Trp Asn Met Leu Phe Ser Ile Phe Ser Met Met Arg Lys Glu Asp
65                  70                  75                  80  
Leu Cys Arg Lys Ile Ile Gly Arg Arg Asn Arg Asn Gln Glu Ala Cys
                85                  90                  95      
Lys Ala Val Met Arg Arg Lys Phe Met Leu Gln Trp Glu Ser His Thr
            100                 105                 110         
Phe Gly Lys Phe His Tyr Lys Phe Phe Arg Asp Val Ser Ser Asp Val
        115                 120                 125             
Phe Tyr Ile Leu Gln Leu Ala Tyr Asp Ser Thr Ser Tyr Tyr Ser Ala
    130                 135                 140                 
Asn Asn Leu Asn Val Phe Leu Met Gly Glu Arg Ala Ser Gly Lys Thr
145                 150                 155                 160 
Ile Val Ile Asn Leu Ala Val Leu Arg Trp Ile Lys Gly Glu Met Trp
                165                 170                 175     
Gln Asn Met Ile Ser Tyr Val Val His Leu Thr Ser His Glu Ile Asn
            180                 185                 190         
Gln Met Thr Asn Ser Ser Leu Ala Glu Leu Ile Ala Lys Asp Trp Pro
        195                 200                 205             
Asp Gly Gln Ala Pro Ile Ala Asp Ile Leu Ser Asp Pro Lys Lys Leu
    210                 215                 220                 
Leu Phe Ile Leu Glu Asp Leu Asp Asn Ile Arg Phe Glu Leu Asn Val
225                 230                 235                 240 
Asn Glu Ser Ala Leu Cys Ser Asn Ser Thr Gln Lys Val Pro Ile Pro
                245                 250                 255     
Val Leu Leu Val Ser Leu Leu Lys Arg Lys Met Ala Pro Gly Cys Trp
            260                 265                 270         
Phe Leu Ile Ser Ser Arg Pro Thr Arg Gly Asn Asn Val Lys Thr Phe
        275                 280                 285             
Leu Lys Glu Val Asp Cys Cys Thr Thr Leu Gln Leu Ser Asn Gly Lys
    290                 295                 300                 
Arg Glu Ile Tyr Phe Asn Ser Phe Phe Lys Asp Arg Gln Arg Ala Ser
305                 310                 315                 320 
Ala Ala Leu Gln Leu Val His Glu Asp Glu Ile Leu Val Gly Leu Cys
                325                 330                 335     
Arg Val Ala Ile Leu Cys Trp Ile Thr Cys Thr Val Leu Lys Arg Gln
            340                 345                 350         
Met Asp Lys Gly Arg Asp Phe Gln Leu Cys Cys Gln Thr Pro Thr Asp
        355                 360                 365             
Leu His Ala His Phe Leu Ala Asp Ala Leu Thr Ser Glu Ala Gly Leu
    370                 375                 380                 
Thr Ala Asn Gln Tyr His Leu Gly Leu Leu Lys Arg Leu Cys Leu Leu
385                 390                 395                 400 
Ala Ala Gly Gly Leu Phe Leu Ser Thr Leu Asn Phe Ser Gly Glu Asp
                405                 410                 415     
Leu Arg Cys Val Gly Phe Thr Glu Ala Asp Val Ser Val Leu Gln Ala
            420                 425                 430         
Ala Asn Ile Leu Leu Pro Ser Asn Thr His Lys Asp Arg Tyr Lys Phe
        435                 440                 445             
Ile His Leu Asn Val Gln Glu Phe Cys Thr Ala Ile Ala Phe Leu Met
    450                 455                 460                 
Ala Val Pro Asn Tyr Leu Ile Pro Ser Gly Ser Arg Glu Tyr Lys Glu
465                 470                 475                 480 
Lys Arg Glu Gln Tyr Ser Asp Phe Asn Gln Val Phe Thr Phe Ile Phe
                485                 490                 495     
Gly Leu Leu Asn Ala Asn Arg Arg Lys Ile Leu Glu Thr Ser Phe Gly
            500                 505                 510         
Tyr Gln Leu Pro Met Val Asp Ser Phe Lys Trp Tyr Ser Val Gly Tyr
        515                 520                 525             
Met Lys His Leu Asp Arg Asp Pro Glu Lys Leu Thr His His Met Pro
    530                 535                 540                 
Leu Phe Tyr Cys Leu Tyr Glu Asn Arg Glu Glu Glu Phe Val Lys Thr
545                 550                 555                 560 
Ile Val Asp Ala Leu Met Glu Val Thr Val Tyr Leu Gln Ser Asp Lys
                565                 570                 575     
Asp Met Met Val Ser Leu Tyr Cys Leu Asp Tyr Cys Cys His Leu Arg
            580                 585                 590         
Thr Leu Lys Leu Ser Val Gln Arg Ile Phe Gln Asn Lys Glu Pro Leu
        595                 600                 605             
Ile Arg Pro Thr Ala Ser Gln Met Lys Ser Leu Val Tyr Trp Arg Glu
    610                 615                 620                 
Ile Cys Ser Leu Phe Tyr Thr Met Glu Ser Leu Arg Glu Leu His Ile
625                 630                 635                 640 
Phe Asp Asn Asp Leu Asn Gly Ile Ser Glu Arg Ile Leu Ser Lys Ala
                645                 650                 655     
Leu Glu His Ser Ser Cys Lys Leu Arg Thr Leu Lys Leu Ser Tyr Val
            660                 665                 670         
Ser Thr Ala Ser Gly Phe Glu Asp Leu Leu Lys Ala Leu Ala Arg Asn
        675                 680                 685             
Arg Ser Leu Thr Tyr Leu Ser Ile Asn Cys Thr Ser Ile Ser Leu Asn
    690                 695                 700                 
Met Phe Ser Leu Leu His Asp Ile Leu His Glu Pro Thr Cys Gln Ile
705                 710                 715                 720 
Ser His Leu Ser Leu Met Lys Cys Asp Leu Arg Ala Ser Glu Cys Glu
                725                 730                 735     
Glu Ile Ala Ser Leu Leu Ile Ser Gly Gly Ser Leu Arg Lys Leu Thr
            740                 745                 750         
Leu Ser Ser Asn Pro Leu Arg Ser Asp Gly Met Asn Ile Leu Cys Asp
        755                 760                 765             
Ala Leu Leu His Pro Asn Cys Thr Leu Ile Ser Leu Val Leu Val Phe
    770                 775                 780                 
Cys Cys Leu Thr Glu Asn Cys Cys Ser Ala Leu Gly Arg Val Leu Leu
785                 790                 795                 800 
Phe Ser Pro Thr Leu Arg Gln Leu Asp Leu Cys Val Asn Arg Leu Lys
                805                 810                 815     
Asn Tyr Gly Val Leu His Val Thr Phe Pro Leu Leu Phe Pro Thr Cys
            820                 825                 830         
Gln Leu Glu Glu Leu His Leu Ser Gly Cys Phe Phe Ser Ser Asp Ile
        835                 840                 845             
Cys Gln Tyr Ile Ala Ile Val Ile Ala Thr Asn Glu Lys Leu Arg Ser
    850                 855                 860                 
Leu Glu Ile Gly Ser Asn Lys Ile Glu Asp Ala Gly Met Gln Leu Leu
865                 870                 875                 880 
Cys Gly Gly Leu Arg His Pro Asn Cys Met Leu Val Asn Ile Gly Leu
                885                 890                 895     
Glu Glu Cys Met Leu Thr Ser Ala Cys Cys Arg Ser Leu Ala Ser Val
            900                 905                 910         
Leu Thr Thr Asn Lys Thr Leu Glu Arg Leu Asn Leu Leu Gln Asn His
        915                 920                 925             
Leu Gly Asn Asp Gly Val Ala Lys Leu Leu Glu Ser Leu Ile Ser Pro
    930                 935                 940                 
Asp Cys Val Leu Lys Val Val Gly Leu Pro Leu Thr Gly Leu Asn Thr
945                 950                 955                 960 
Gln Thr Gln Gln Leu Leu Met Thr Val Lys Glu Arg Lys Pro Ser Leu
                965                 970                 975     
Ile Phe Leu Ser Glu Thr Trp Ser Leu Lys Glu Gly Arg Glu Ile Gly
            980                 985                 990         
Val Thr Pro Ala Ser Gln Pro Gly Ser Ile Ile Pro Asn Ser Asn Leu
        995                 1000                1005            
Asp Tyr Met Phe Phe Lys Phe Pro Arg Met Ser Ala Ala Met Arg Thr
    1010                1015                1020                
Ser Asn Thr Ala Ser Arg Gln Pro Leu
1025                1030            


<210> 7235
<211> 569
<212> PRT
<213> Homo sapiens

<400> 7235
Met Arg Asp Asn Thr Ser Pro Ile Ser Val Ile Leu Val Ser Ser Gly
 1               5                  10                  15      
Ser Arg Gly Asn Lys Leu Leu Phe Arg Tyr Pro Phe Gln Arg Ser Gln
            20                  25                  30          
Glu His Pro Ala Ser Gln Thr Ser Lys Pro Arg Ser Arg Tyr Ala Ala
        35                  40                  45              
Ser Asn Thr Gly Asp His Ala Asp Glu Gln Asp Gly Asp Ser Arg Phe
    50                  55                  60                  
Ser Asp Val Ile Leu Ala Thr Ile Leu Ala Thr Lys Ser Glu Met Cys
65                  70                  75                  80  
Gly Gln Lys Phe Glu Leu Lys Ile Asp Asn Val Arg Phe Val Gly His
                85                  90                  95      
Pro Thr Leu Leu Gln His Ala Leu Gly Gln Ile Ser Lys Thr Asp Pro
            100                 105                 110         
Ser Pro Lys Arg Glu Ala Pro Thr Met Ile Leu Phe Asn Val Val Phe
        115                 120                 125             
Ala Leu Arg Ala Asn Ala Asp Pro Ser Val Ile Asn Cys Leu His Asn
    130                 135                 140                 
Leu Ser Arg Arg Ile Ala Thr Val Leu Gln His Glu Glu Arg Arg Cys
145                 150                 155                 160 
Gln Tyr Leu Thr Arg Glu Ala Lys Leu Ile Leu Ala Leu Gln Asp Glu
                165                 170                 175     
Val Ser Ala Met Ala Asp Gly Asn Glu Gly Pro Gln Ser Pro Phe His
            180                 185                 190         
His Ile Leu Pro Lys Cys Lys Leu Ala Arg Asp Leu Lys Glu Ala Tyr
        195                 200                 205             
Asp Ser Leu Cys Thr Ser Gly Val Val Arg Leu His Ile Asn Ser Trp
    210                 215                 220                 
Leu Glu Val Ser Phe Cys Leu Pro His Lys Ile His Tyr Ala Ala Ser
225                 230                 235                 240 
Ser Leu Ile Pro Pro Glu Ala Ile Glu Arg Ser Leu Lys Ala Ile Arg
                245                 250                 255     
Pro Tyr His Ala Leu Leu Leu Leu Ser Asp Glu Lys Ser Leu Leu Gly
            260                 265                 270         
Glu Leu Pro Ile Asp Cys Ser Pro Ala Leu Val Arg Val Ile Lys Thr
        275                 280                 285             
Thr Ser Ala Val Lys Asn Leu Gln Gln Leu Ala Gln Asp Ala Asp Leu
    290                 295                 300                 
Ala Leu Leu Gln Val Phe Gln Leu Ala Ala His Leu Val Tyr Trp Gly
305                 310                 315                 320 
Lys Ala Ile Ile Ile Tyr Pro Leu Cys Glu Asn Asn Val Tyr Met Leu
                325                 330                 335     
Ser Pro Asn Ala Ser Val Cys Leu Tyr Ser Pro Leu Ala Glu Gln Phe
            340                 345                 350         
Ser His Gln Phe Pro Ser His Asp Leu Pro Ser Val Leu Ala Lys Phe
        355                 360                 365             
Ser Leu Pro Val Ser Leu Ser Glu Phe Arg Asn Pro Leu Ala Pro Ala
    370                 375                 380                 
Val Gln Glu Thr Gln Leu Ile Gln Met Val Val Trp Met Leu Gln Arg
385                 390                 395                 400 
Arg Leu Leu Ile Gln Leu His Thr Tyr Val Cys Leu Met Ala Ser Pro
                405                 410                 415     
Ser Glu Glu Glu Pro Arg Pro Arg Glu Asp Asp Val Pro Phe Thr Ala
            420                 425                 430         
Arg Val Gly Gly Arg Ser Leu Ser Thr Pro Asn Ala Leu Ser Phe Gly
        435                 440                 445             
Ser Pro Thr Ser Ser Asp Asp Met Thr Leu Thr Ser Pro Ser Met Asp
    450                 455                 460                 
Asn Ser Ser Ala Glu Leu Leu Pro Ser Gly Asp Ser Pro Leu Asn Gln
465                 470                 475                 480 
Arg Met Thr Glu Asn Leu Leu Ala Ser Leu Ser Glu His Glu Arg Ala
                485                 490                 495     
Ala Ile Leu Ser Val Pro Ala Ala Gln Asn Pro Glu Asp Leu Arg Met
            500                 505                 510         
Phe Ala Arg Leu Leu His Tyr Phe Arg Gly Arg His His Leu Glu Glu
        515                 520                 525             
Ile Met Tyr Asn Glu Asn Thr Arg Arg Ser Gln Leu Leu Met Leu Phe
    530                 535                 540                 
Asp Lys Phe Arg Ser Val Leu Val Val Thr Thr His Glu Asp Pro Val
545                 550                 555                 560 
Ile Ala Val Phe Gln Ala Leu Leu Pro
                565                 


<210> 7236
<211> 958
<212> PRT
<213> Homo sapiens

<400> 7236
Met Ser Ser Cys Arg Ser Leu Cys Cys Gly Asp Ile Ser Gln Ser Ala
 1               5                  10                  15      
Val Leu Phe Leu Cys Gln Gly Thr Leu Ala Met Leu Asp Trp Gln Asn
            20                  25                  30          
Gly Ser Met Gly Arg Ser Gly Glu Ala Leu Leu Leu Asp Thr Ala His
        35                  40                  45              
Val Leu Phe Thr Leu Ser Ser Gln Ile Lys Glu Pro Thr Leu Glu Met
    50                  55                  60                  
Phe Leu Ser Arg Ile Leu Ala Ser Trp Thr Asn Ser Ala Ile Gln Val
65                  70                  75                  80  
Leu Glu Ser Ser Ser Pro Ser Leu Thr Asp Ser Leu Asn Gly Asn Ser
                85                  90                  95      
Ser Ile Val Gly Arg Leu Leu Glu Tyr Val Tyr Thr His Trp Glu His
            100                 105                 110         
Pro Leu Asp Ala Leu Arg His Gln Thr Lys Ile Met Phe Lys Asn Leu
        115                 120                 125             
Leu Gln Met His Arg Leu Thr Val Glu Gly Ala Asp Phe Val Pro Asp
    130                 135                 140                 
Pro Phe Phe Val Glu Leu Thr Glu Ser Leu Leu Arg Leu Glu Trp His
145                 150                 155                 160 
Ile Lys Gly Lys Tyr Thr Cys Leu Gly Cys Leu Val Glu Cys Ile Gly
                165                 170                 175     
Val Glu His Ile Leu Ala Ile Asp Lys Thr Ile Pro Ser Gln Ile Leu
            180                 185                 190         
Glu Val Met Gly Asp Gln Ser Leu Val Pro Tyr Ala Ser Asp Leu Leu
        195                 200                 205             
Glu Thr Met Phe Arg Asn His Lys Ser His Leu Lys Ser Gln Thr Ala
    210                 215                 220                 
Glu Ser Ser Trp Ile Asp Gln Trp His Glu Thr Trp Val Ser Pro Leu
225                 230                 235                 240 
Leu Phe Ile Leu Cys Glu Gly Asn Leu Asp Gln Lys Ser Tyr Val Ile
                245                 250                 255     
Asp Tyr Tyr Leu Pro Lys Leu Leu Ser Tyr Ser Pro Glu Ser Leu Gln
            260                 265                 270         
Tyr Met Val Lys Ile Leu Gln Thr Ser Ile Asp Ala Lys Thr Gly Gln
        275                 280                 285             
Glu Gln Ser Phe Pro Ser Leu Gly Ser Cys Asn Ser Arg Gly Ala Leu
    290                 295                 300                 
Gly Ala Leu Met Ala Cys Leu Arg Ile Ala Arg Ala His Gly His Leu
305                 310                 315                 320 
Gln Ser Ala Thr Asp Thr Trp Glu Asn Leu Val Ser Asp Ala Arg Ile
                325                 330                 335     
Lys Gln Gly Leu Ile His Gln His Cys Gln Val Arg Ile Asp Thr Leu
            340                 345                 350         
Gly Leu Leu Cys Glu Ser Asn Arg Ser Thr Glu Ile Val Ser Met Glu
        355                 360                 365             
Glu Met Gln Trp Ile Gln Phe Phe Ile Thr Tyr Asn Leu Asn Ser Gln
    370                 375                 380                 
Ser Pro Gly Val Arg Gln Gln Ile Cys Ser Leu Leu Lys Lys Leu Phe
385                 390                 395                 400 
Cys Arg Ile Gln Glu Ser Ser Gln Val Leu Tyr Lys Leu Glu Gln Ser
                405                 410                 415     
Lys Ser Lys Arg Glu Pro Glu Asn Glu Leu Thr Lys Gln His Pro Ser
            420                 425                 430         
Val Ser Leu Gln Gln Tyr Lys Asn Phe Met Ser Ser Ile Cys Asn Ser
        435                 440                 445             
Leu Phe Glu Ala Leu Phe Pro Gly Ser Ser Tyr Ser Thr Arg Phe Ser
    450                 455                 460                 
Ala Leu Thr Ile Leu Gly Ser Ile Ala Glu Val Phe His Val Pro Glu
465                 470                 475                 480 
Gly Arg Ile Tyr Thr Val Tyr Gln Leu Ser His Asp Ile Asp Val Gly
                485                 490                 495     
Arg Phe Gln Thr Leu Met Glu Cys Phe Thr Ser Thr Phe Glu Asp Val
            500                 505                 510         
Lys Ile Leu Ala Phe Asp Leu Leu Met Lys Leu Ser Lys Thr Ala Val
        515                 520                 525             
His Phe Gln Asp Ser Gly Lys Leu Gln Gly Leu Phe Gln Ala Ala Leu
    530                 535                 540                 
Glu Leu Ser Thr Ser Thr Lys Pro Tyr Asp Cys Val Thr Ala Ser Tyr
545                 550                 555                 560 
Leu Leu Asn Phe Leu Ile Trp Gln Asp Ala Leu Pro Ser Ser Leu Ser
                565                 570                 575     
Ala Tyr Leu Thr Gln Gln Val Ala Cys Asp Asn Gly Asp Arg Pro Ala
            580                 585                 590         
Ala Val Val Glu Arg Asn Thr Leu Met Val Ile Lys Cys Leu Met Glu
        595                 600                 605             
Asn Leu Glu Glu Glu Val Ser Gln Ala Glu Asn Ser Leu Leu Gln Ala
    610                 615                 620                 
Ala Ala Ala Phe Pro Met Tyr Gly Arg Val His Cys Ile Thr Gly Ala
625                 630                 635                 640 
Leu Gln Lys Leu Ser Leu Asn Ser Leu Gln Leu Val Ser Glu Trp Arg
                645                 650                 655     
Pro Val Val Glu Lys Leu Leu Leu Met Ser Tyr Arg Leu Ser Thr Val
            660                 665                 670         
Val Ser Pro Val Ile Gln Ser Ser Ser Pro Glu Gly Leu Ile Pro Met
        675                 680                 685             
Asp Thr Asp Ser Glu Ser Ala Ser Arg Leu Gln Met Ile Leu Asn Glu
    690                 695                 700                 
Ile Gln Pro Arg Asp Thr Asn Asp Tyr Phe Asn Gln Ala Lys Ile Leu
705                 710                 715                 720 
Lys Glu His Asp Ser Phe Asp Met Lys Asp Leu Asn Ala Ser Val Val
                725                 730                 735     
Asn Ile Asp Thr Ser Thr Glu Ile Lys Gly Lys Glu Val Lys Thr Cys
            740                 745                 750         
Asp Val Thr Ala Gln Met Val Leu Val Cys Cys Trp Arg Ser Met Lys
        755                 760                 765             
Glu Val Ala Leu Leu Leu Gly Met Leu Cys Gln Leu Leu Pro Met Gln
    770                 775                 780                 
Pro Val Pro Glu Ser Ser Asp Gly Leu Leu Thr Val Glu Gln Val Lys
785                 790                 795                 800 
Glu Ile Gly Asp Tyr Phe Lys Gln His Leu Leu Gln Ser Arg His Arg
                805                 810                 815     
Gly Ala Phe Glu Leu Ala Tyr Thr Gly Phe Val Lys Leu Thr Glu Val
            820                 825                 830         
Leu Asn Arg Cys Pro Asn Val Ser Leu Gln Lys Leu Pro Glu Gln Trp
        835                 840                 845             
Leu Trp Ser Val Leu Glu Glu Ile Lys Cys Ser Asp Pro Ser Ser Lys
    850                 855                 860                 
Leu Cys Ala Thr Arg Arg Ser Ala Gly Ile Pro Phe Tyr Ile Gln Ala
865                 870                 875                 880 
Leu Leu Ala Ser Glu Pro Lys Lys Gly Arg Met Asp Leu Leu Lys Ile
                885                 890                 895     
Thr Met Lys Glu Leu Ile Ser Leu Ala Gly Pro Thr Asp Asp Ile Gln
            900                 905                 910         
Ser Thr Val Pro Gln Val His Ala Leu Asn Ile Leu Arg Ala Leu Phe
        915                 920                 925             
Arg Asp Thr Arg Leu Gly Glu Asn Ile Ile Pro Tyr Val Ala Asp Gly
    930                 935                 940                 
Ala Lys Ala Ala Ile Leu Gly Phe Thr Ser Pro Val Trp Ala
945                 950                 955             


<210> 7237
<211> 1953
<212> PRT
<213> Homo sapiens

<400> 7237
Met Gly Val Lys Lys Lys Lys Glu Met Gln Val Ala Ala Leu Thr Ile
 1               5                  10                  15      
Cys His Gln Asp Leu Glu Thr Leu Lys Ser Phe Ala Asp Val Glu Gly
            20                  25                  30          
Lys Asn Leu Ala Ser Leu Leu Leu His Cys Val Gln Leu Thr Asp Gly
        35                  40                  45              
Val Ser Gln Ile His Tyr Ile Lys Gln Ile Val Pro Leu Leu Glu Lys
    50                  55                  60                  
Ala Asp Lys Asn Gly Met Cys Asp Pro Thr Ile Gln Ser Cys Leu Asp
65                  70                  75                  80  
Ile Leu Ala Gly Ile Tyr Leu Ser Leu Ser Leu Lys Asn Pro Leu Lys
                85                  90                  95      
Lys Val Leu Ala Ser Ser Leu Asn Ser Leu Pro Asp Phe Phe Leu Pro
            100                 105                 110         
Glu Ala Met His Arg Phe Thr Ser Arg Leu Gln Glu Glu Leu Asn Thr
        115                 120                 125             
Thr Asp Leu Tyr Ser Tyr Arg Lys Val Thr Asp Asn Ile Ser Ser Cys
    130                 135                 140                 
Met Glu Asn Phe Asn Leu Gly Arg Ala Ser Val Asn Asn Leu Leu Lys
145                 150                 155                 160 
Asn Val Leu His Phe Leu Gln Lys Ser Leu Ile Glu Ile Leu Glu Glu
                165                 170                 175     
Asn Arg Lys Cys Ala Gly Asn His Ile Ile Gln Thr Gln Leu Met Asn
            180                 185                 190         
Asp Leu Leu Val Gly Ile Arg Val Ser Met Met Leu Val Gln Lys Val
        195                 200                 205             
Gln Asp Phe Gln Gly Asn Leu Trp Lys Thr Ser Asp Ser Pro Ile Trp
    210                 215                 220                 
Gln Asn Met Cys Gly Leu Leu Ser Ile Phe Thr Lys Val Leu Ser Asp
225                 230                 235                 240 
Asp Asp Leu Leu Gln Thr Val Gln Ser Thr Ser Gly Leu Ala Ile Ile
                245                 250                 255     
Leu Phe Ile Lys Thr Met Phe His Pro Ser Glu Lys Ile Pro His Leu
            260                 265                 270         
Ile Ser Ser Val Leu Leu Arg Ser Val Asp Cys Thr Ser Val Pro Glu
        275                 280                 285             
Trp Phe Met Ser Ser Cys Arg Ser Leu Cys Cys Gly Asp Ile Ser Gln
    290                 295                 300                 
Ser Ala Val Leu Phe Leu Cys Gln Gly Thr Leu Ala Met Leu Asp Trp
305                 310                 315                 320 
Gln Asn Gly Ser Met Gly Arg Ser Gly Glu Ala Leu Leu Leu Asp Thr
                325                 330                 335     
Ala His Val Leu Phe Thr Leu Ser Ser Gln Ile Lys Glu Pro Thr Leu
            340                 345                 350         
Glu Met Phe Leu Ser Arg Ile Leu Ala Ser Trp Thr Asn Ser Ala Ile
        355                 360                 365             
Gln Val Leu Glu Ser Ser Ser Pro Ser Leu Thr Asp Ser Leu Asn Gly
    370                 375                 380                 
Asn Ser Ser Ile Val Gly Arg Leu Leu Glu Tyr Val Tyr Thr His Trp
385                 390                 395                 400 
Glu His Pro Leu Asp Ala Leu Arg His Gln Thr Lys Ile Met Phe Lys
                405                 410                 415     
Asn Leu Leu Gln Met His Arg Leu Thr Val Glu Gly Ala Asp Phe Val
            420                 425                 430         
Pro Asp Pro Phe Phe Val Glu Leu Thr Glu Ser Leu Leu Arg Leu Glu
        435                 440                 445             
Trp His Ile Lys Gly Lys Tyr Thr Cys Leu Gly Cys Leu Val Glu Cys
    450                 455                 460                 
Ile Gly Val Glu His Ile Leu Ala Ile Asp Lys Thr Ile Pro Ser Gln
465                 470                 475                 480 
Ile Leu Glu Val Met Gly Asp Gln Ser Leu Val Pro Tyr Ala Ser Asp
                485                 490                 495     
Leu Leu Glu Thr Met Phe Arg Asn His Lys Ser His Leu Lys Ser Gln
            500                 505                 510         
Thr Ala Glu Ser Ser Trp Ile Asp Gln Trp His Glu Thr Trp Val Ser
        515                 520                 525             
Pro Leu Leu Phe Ile Leu Cys Glu Gly Asn Leu Asp Gln Lys Ser Tyr
    530                 535                 540                 
Val Ile Asp Tyr Tyr Leu Pro Lys Leu Leu Ser Tyr Ser Pro Glu Ser
545                 550                 555                 560 
Leu Gln Tyr Met Val Lys Ile Leu Gln Thr Ser Ile Asp Ala Lys Thr
                565                 570                 575     
Gly Gln Glu Gln Ser Phe Pro Ser Leu Gly Ser Cys Asn Ser Arg Gly
            580                 585                 590         
Ala Leu Gly Ala Leu Met Ala Cys Leu Arg Ile Ala Arg Ala His Gly
        595                 600                 605             
His Leu Gln Ser Ala Thr Asp Thr Trp Glu Asn Leu Val Ser Asp Ala
    610                 615                 620                 
Arg Ile Lys Gln Gly Leu Ile His Gln His Cys Gln Val Arg Ile Asp
625                 630                 635                 640 
Thr Leu Gly Leu Leu Cys Glu Ser Asn Arg Ser Thr Glu Ile Val Ser
                645                 650                 655     
Met Glu Glu Met Gln Trp Ile Gln Phe Phe Ile Thr Tyr Asn Leu Asn
            660                 665                 670         
Ser Gln Ser Pro Gly Val Arg Gln Gln Ile Cys Ser Leu Leu Lys Lys
        675                 680                 685             
Leu Phe Cys Arg Ile Gln Glu Ser Ser Gln Val Leu Tyr Lys Leu Glu
    690                 695                 700                 
Gln Ser Lys Ser Lys Arg Glu Pro Glu Asn Glu Leu Thr Lys Gln His
705                 710                 715                 720 
Pro Ser Val Ser Leu Gln Gln Tyr Lys Asn Phe Met Ser Ser Ile Cys
                725                 730                 735     
Asn Ser Leu Phe Glu Ala Leu Phe Pro Gly Ser Ser Tyr Ser Thr Arg
            740                 745                 750         
Phe Ser Ala Leu Thr Ile Leu Gly Ser Ile Ala Glu Val Phe His Val
        755                 760                 765             
Pro Glu Gly Arg Ile Tyr Thr Val Tyr Gln Leu Ser His Asp Ile Asp
    770                 775                 780                 
Val Gly Arg Phe Gln Thr Leu Met Glu Cys Phe Thr Ser Thr Phe Glu
785                 790                 795                 800 
Asp Val Lys Ile Leu Ala Phe Asp Leu Leu Met Lys Leu Ser Lys Thr
                805                 810                 815     
Ala Val His Phe Gln Asp Ser Gly Lys Leu Gln Gly Leu Phe Gln Ala
            820                 825                 830         
Ala Leu Glu Leu Ser Thr Ser Thr Lys Pro Tyr Asp Cys Val Thr Ala
        835                 840                 845             
Ser Tyr Leu Leu Asn Phe Leu Ile Trp Gln Asp Ala Leu Pro Ser Ser
    850                 855                 860                 
Leu Ser Ala Tyr Leu Thr Gln Gln Val Ala Cys Asp Asn Gly Asp Arg
865                 870                 875                 880 
Pro Ala Ala Val Val Glu Arg Asn Thr Leu Met Val Ile Lys Cys Leu
                885                 890                 895     
Met Glu Asn Leu Glu Glu Glu Val Ser Gln Ala Glu Asn Ser Leu Leu
            900                 905                 910         
Gln Ala Ala Ala Ala Phe Pro Met Tyr Gly Arg Val His Cys Ile Thr
        915                 920                 925             
Gly Ala Leu Gln Lys Leu Ser Leu Asn Ser Leu Gln Leu Val Ser Glu
    930                 935                 940                 
Trp Arg Pro Val Val Glu Lys Leu Leu Leu Met Ser Tyr Arg Leu Ser
945                 950                 955                 960 
Thr Val Val Ser Pro Val Ile Gln Ser Ser Ser Pro Glu Gly Leu Ile
                965                 970                 975     
Pro Met Asp Thr Asp Ser Glu Ser Ala Ser Arg Leu Gln Met Ile Leu
            980                 985                 990         
Asn Glu Ile Gln Pro Arg Asp Thr Asn Asp Tyr Phe Asn Gln Ala Lys
        995                 1000                1005            
Ile Leu Lys Glu His Asp Ser Phe Asp Met Lys Asp Leu Asn Ala Ser
    1010                1015                1020                
Val Val Asn Ile Asp Thr Ser Thr Glu Ile Lys Gly Lys Glu Val Lys
1025                1030                1035                1040
Thr Cys Asp Val Thr Ala Gln Met Val Leu Val Cys Cys Trp Arg Ser
                1045                1050                1055    
Met Lys Glu Val Ala Leu Leu Leu Gly Met Leu Cys Gln Leu Leu Pro
            1060                1065                1070        
Met Gln Pro Val Pro Glu Ser Ser Asp Gly Leu Leu Thr Val Glu Gln
        1075                1080                1085            
Val Lys Glu Ile Gly Asp Tyr Phe Lys Gln His Leu Leu Gln Ser Arg
    1090                1095                1100                
His Arg Gly Ala Phe Glu Leu Ala Tyr Thr Gly Phe Val Lys Leu Thr
1105                1110                1115                1120
Glu Val Leu Asn Arg Cys Pro Asn Val Ser Leu Gln Lys Leu Pro Glu
                1125                1130                1135    
Gln Trp Leu Trp Ser Val Leu Glu Glu Ile Lys Cys Ser Asp Pro Ser
            1140                1145                1150        
Ser Lys Leu Cys Ala Thr Arg Arg Ser Ala Gly Ile Pro Phe Tyr Ile
        1155                1160                1165            
Gln Ala Leu Leu Ala Ser Glu Pro Lys Lys Gly Arg Met Asp Leu Leu
    1170                1175                1180                
Lys Ile Thr Met Lys Glu Leu Ile Ser Leu Ala Gly Pro Thr Asp Asp
1185                1190                1195                1200
Ile Gln Ser Thr Val Pro Gln Val His Ala Leu Asn Ile Leu Arg Ala
                1205                1210                1215    
Leu Phe Arg Asp Thr Arg Leu Gly Glu Asn Ile Ile Pro Tyr Val Ala
            1220                1225                1230        
Asp Gly Ala Lys Ala Ala Ile Leu Gly Phe Thr Ser Pro Val Trp Ala
        1235                1240                1245            
Val Arg Asn Ser Ser Thr Leu Leu Phe Ser Ala Leu Ile Thr Arg Ile
    1250                1255                1260                
Phe Gly Val Lys Arg Ala Lys Asp Glu His Ser Lys Thr Asn Arg Met
1265                1270                1275                1280
Thr Gly Arg Glu Phe Phe Ser Arg Phe Pro Glu Leu Tyr Pro Phe Leu
                1285                1290                1295    
Leu Lys Gln Leu Glu Thr Val Ala Asn Thr Val Asp Ser Asp Met Gly
            1300                1305                1310        
Glu Pro Asn Arg His Pro Ser Met Phe Leu Leu Leu Leu Val Leu Glu
        1315                1320                1325            
Arg Leu Tyr Ala Ser Pro Met Asp Gly Thr Ser Ser Ala Leu Ser Met
    1330                1335                1340                
Gly Pro Phe Val Pro Phe Ile Met Arg Cys Gly His Ser Pro Val Tyr
1345                1350                1355                1360
His Ser Arg Glu Met Ala Ala Arg Ala Leu Val Pro Phe Val Met Ile
                1365                1370                1375    
Asp His Ile Pro Asn Thr Ile Arg Thr Leu Leu Ser Thr Leu Pro Ser
            1380                1385                1390        
Cys Thr Asp Gln Cys Phe Arg Gln Asn His Ile His Gly Thr Leu Leu
        1395                1400                1405            
Gln Val Phe His Leu Leu Gln Ala Tyr Ser Asp Ser Lys His Gly Thr
    1410                1415                1420                
Asn Ser Asp Phe Gln His Glu Leu Thr Asp Ile Thr Val Cys Thr Lys
1425                1430                1435                1440
Ala Lys Leu Trp Leu Ala Lys Arg Gln Asn Pro Cys Leu Val Thr Arg
                1445                1450                1455    
Ala Val Tyr Ile Asp Ile Leu Phe Leu Leu Thr Cys Cys Leu Asn Arg
            1460                1465                1470        
Ser Ala Lys Asp Asn Gln Pro Val Leu Glu Ser Leu Gly Phe Trp Glu
        1475                1480                1485            
Glu Val Arg Gly Ile Ile Ser Gly Ser Glu Leu Ile Thr Gly Phe Pro
    1490                1495                1500                
Trp Ala Phe Lys Val Pro Gly Leu Pro Gln Tyr Leu Gln Ser Leu Thr
1505                1510                1515                1520
Arg Leu Ala Ile Ala Ala Val Trp Ala Ala Ala Ala Lys Ser Gly Glu
                1525                1530                1535    
Arg Glu Thr Asn Val Pro Ile Ser Phe Ser Gln Leu Leu Glu Ser Ala
            1540                1545                1550        
Phe Pro Glu Val Arg Ser Leu Thr Leu Glu Ala Leu Leu Glu Lys Phe
        1555                1560                1565            
Leu Ala Ala Ala Ser Gly Leu Gly Glu Lys Gly Val Pro Pro Leu Leu
    1570                1575                1580                
Cys Asn Met Gly Glu Lys Phe Leu Leu Leu Ala Met Lys Glu Asn His
1585                1590                1595                1600
Pro Glu Cys Phe Cys Lys Ile Leu Lys Ile Leu His Cys Met Asp Pro
                1605                1610                1615    
Gly Glu Trp Leu Pro Gln Thr Glu His Cys Val His Leu Thr Pro Lys
            1620                1625                1630        
Glu Phe Leu Ile Trp Thr Met Asp Ile Ala Ser Asn Glu Arg Ser Glu
        1635                1640                1645            
Ile Gln Ser Val Ala Leu Arg Leu Ala Ser Lys Val Ile Ser His His
    1650                1655                1660                
Met Gln Thr Cys Val Glu Asn Arg Glu Leu Ile Ala Ala Glu Leu Lys
1665                1670                1675                1680
Gln Trp Val Gln Leu Val Ile Leu Ser Cys Glu Asp His Leu Pro Thr
                1685                1690                1695    
Glu Ser Arg Leu Ala Val Val Glu Val Leu Thr Ser Thr Thr Pro Leu
            1700                1705                1710        
Phe Leu Thr Asn Pro His Pro Ile Leu Glu Leu Gln Asp Thr Leu Ala
        1715                1720                1725            
Leu Trp Lys Cys Val Leu Thr Leu Leu Gln Ser Glu Glu Gln Ala Val
    1730                1735                1740                
Arg Asp Ala Ala Thr Glu Thr Val Thr Thr Ala Met Ser Gln Glu Asn
1745                1750                1755                1760
Thr Cys Gln Ser Thr Glu Phe Ala Phe Cys Gln Val Asp Ala Ser Ile
                1765                1770                1775    
Ala Leu Ala Leu Ala Leu Ala Val Leu Cys Asp Leu Leu Gln Gln Trp
            1780                1785                1790        
Asp Gln Leu Ala Pro Gly Leu Pro Ile Leu Leu Gly Trp Leu Leu Gly
        1795                1800                1805            
Glu Ser Asp Asp Leu Val Ala Cys Val Glu Ser Met His Gln Val Glu
    1810                1815                1820                
Glu Asp Tyr Leu Phe Glu Lys Ala Glu Val Asn Phe Trp Ala Glu Thr
1825                1830                1835                1840
Leu Ile Phe Val Lys Tyr Leu Cys Lys His Leu Phe Cys Leu Leu Ser
                1845                1850                1855    
Lys Ser Gly Trp Arg Pro Pro Ser Pro Glu Met Leu Cys His Leu Gln
            1860                1865                1870        
Arg Met Val Ser Glu Gln Cys His Leu Leu Ser Gln Phe Phe Arg Glu
        1875                1880                1885            
Leu Pro Pro Ala Ala Glu Phe Val Lys Thr Val Glu Phe Thr Arg Leu
    1890                1895                1900                
Arg Ile Gln Glu Glu Arg Thr Leu Ala Cys Leu Arg Leu Leu Ala Phe
1905                1910                1915                1920
Leu Glu Gly Lys Glu Gly Glu Asp Thr Leu Val Leu Ser Val Trp Asp
                1925                1930                1935    
Ser Tyr Ala Glu Ser Arg Gln Leu Thr Leu Pro Arg Thr Glu Ala Ala
            1940                1945                1950        
Cys
    


<210> 7238
<211> 353
<212> PRT
<213> Homo sapiens

<400> 7238
Asp Ala Trp Ala Ala Gly Val Gly Gly Pro Pro Lys Met Gly Asn Thr
 1               5                  10                  15      
Thr Ser Cys Cys Val Ser Ser Ser Pro Lys Leu Arg Arg Asn Ala His
            20                  25                  30          
Ser Arg Leu Glu Ser Tyr Arg Pro Asp Thr Asp Leu Ser Arg Glu Asp
        35                  40                  45              
Thr Gly Cys Asn Leu Gln His Ile Ser Asp Arg Glu Asn Ile Asp Asp
    50                  55                  60                  
Leu Asn Met Glu Phe Asn Pro Ser Asp His Pro Arg Ala Ser Thr Ile
65                  70                  75                  80  
Phe Leu Ser Lys Ser Gln Thr Asp Val Arg Glu Lys Arg Lys Ser Leu
                85                  90                  95      
Phe Ile Asn His His Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser
            100                 105                 110         
Cys Ser Thr Ile Phe Leu Asp Asp Ser Thr Val Ser Gln Pro Asn Leu
        115                 120                 125             
Lys Tyr Thr Ile Lys Cys Val Ala Leu Ala Ile Tyr Tyr His Ile Lys
    130                 135                 140                 
Asn Arg Asp Pro Asp Gly Arg Met Leu Leu Asp Ile Phe Asp Glu Asn
145                 150                 155                 160 
Leu His Pro Leu Ser Lys Ser Glu Val Pro Pro Asp Tyr Asp Lys His
                165                 170                 175     
Asn Pro Glu Gln Lys Gln Ile Tyr Arg Phe Val Arg Thr Leu Phe Ser
            180                 185                 190         
Ala Ala Gln Leu Thr Ala Glu Cys Ala Ile Val Thr Leu Val Tyr Leu
        195                 200                 205             
Glu Arg Leu Leu Thr Tyr Ala Glu Ile Asp Ile Cys Pro Ala Asn Trp
    210                 215                 220                 
Lys Arg Ile Val Leu Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Asp
225                 230                 235                 240 
Asp Gln Ala Val Trp Asn Val Asp Tyr Cys Gln Ile Leu Lys Asp Ile
                245                 250                 255     
Thr Val Glu Asp Met Asn Glu Leu Glu Arg Gln Phe Leu Glu Leu Leu
            260                 265                 270         
Gln Phe Asn Ile Asn Val Pro Ser Ser Val Tyr Ala Lys Tyr Tyr Phe
        275                 280                 285             
Asp Leu Arg Ser Leu Ala Glu Ala Asn Asn Leu Ser Phe Pro Leu Glu
    290                 295                 300                 
Pro Leu Ser Arg Glu Arg Ala His Lys Leu Glu Ala Ile Ser Arg Leu
305                 310                 315                 320 
Cys Glu Asp Lys Tyr Lys Asp Leu Arg Arg Ser Ala Arg Lys Arg Ser
                325                 330                 335     
Ala Ser Ala Asp Asn Leu Thr Leu Pro Arg Trp Ser Pro Ala Ile Ile
            340                 345                 350         
Ser
    


<210> 7239
<211> 316
<212> PRT
<213> Homo sapiens

<400> 7239
Met Gly Asn Thr Thr Ser Cys Cys Val Ser Ser Ser Pro Lys Leu Arg
 1               5                  10                  15      
Arg Asn Ala His Ser Arg Leu Glu Ser Tyr Arg Pro Asp Thr Asp Leu
            20                  25                  30          
Ser Arg Glu Asp Thr Gly Cys Asn Leu Gln His Ile Ser Asp Arg Glu
        35                  40                  45              
Asn Ile Asp Val Gly Glu Lys Arg Lys Ser Leu Phe Ile Asn His His
    50                  55                  60                  
Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser Cys Ser Thr Ile Phe
65                  70                  75                  80  
Leu Asp Asp Ser Thr Val Ser Gln Pro Asn Leu Lys Tyr Thr Ile Lys
                85                  90                  95      
Cys Val Ala Leu Ala Ile Tyr Tyr His Ile Lys Asn Arg Asp Pro Asp
            100                 105                 110         
Gly Arg Met Leu Leu Asp Ile Phe Asp Glu Asn Leu His Pro Leu Ser
        115                 120                 125             
Lys Ser Glu Val Pro Pro Asp Tyr Asp Lys His Asn Pro Glu Gln Lys
    130                 135                 140                 
Gln Ile Tyr Arg Phe Val Arg Thr Leu Phe Ser Ala Ala Gln Leu Thr
145                 150                 155                 160 
Ala Glu Cys Ala Ile Val Thr Leu Val Tyr Leu Glu Arg Leu Leu Thr
                165                 170                 175     
Tyr Ala Glu Ile Asp Ile Cys Pro Ala Asn Trp Lys Arg Ile Val Leu
            180                 185                 190         
Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Asp Asp Gln Ala Val Trp
        195                 200                 205             
Asn Val Asp Tyr Cys Gln Ile Leu Lys Asp Ile Thr Val Glu Asp Met
    210                 215                 220                 
Asn Glu Leu Glu Arg Gln Phe Leu Glu Leu Leu Gln Phe Asn Ile Asn
225                 230                 235                 240 
Val Pro Ser Ser Val Tyr Ala Lys Tyr Tyr Phe Asp Leu Arg Ser Leu
                245                 250                 255     
Ala Glu Ala Asn Asn Leu Ser Phe Pro Leu Glu Pro Leu Ser Arg Glu
            260                 265                 270         
Arg Ala His Lys Leu Glu Ala Ile Ser Arg Leu Cys Glu Asp Lys Tyr
        275                 280                 285             
Lys Asp Leu Arg Arg Ser Ala Arg Lys Arg Ser Ala Ser Ala Asp Asn
    290                 295                 300                 
Leu Thr Leu Pro Arg Trp Ser Pro Ala Ile Ile Ser
305                 310                 315     


<210> 7240
<211> 287
<212> PRT
<213> Homo sapiens

<400> 7240
Met Glu Phe Asn Pro Ser Asp His Pro Arg Ala Ser Thr Ile Phe Leu
 1               5                  10                  15      
Ser Lys Ser Gln Thr Asp Val Arg Glu Lys Arg Lys Ser Leu Phe Ile
            20                  25                  30          
Asn His His Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser Cys Ser
        35                  40                  45              
Thr Ile Phe Leu Asp Asp Ser Thr Val Ser Gln Pro Asn Leu Lys Tyr
    50                  55                  60                  
Thr Ile Lys Cys Val Ala Leu Ala Ile Tyr Tyr His Ile Lys Asn Arg
65                  70                  75                  80  
Asp Pro Asp Gly Arg Met Leu Leu Asp Ile Phe Asp Glu Asn Leu His
                85                  90                  95      
Pro Leu Ser Lys Ser Glu Val Pro Pro Asp Tyr Asp Lys His Asn Pro
            100                 105                 110         
Glu Gln Lys Gln Ile Tyr Arg Phe Val Arg Thr Leu Phe Ser Ala Ala
        115                 120                 125             
Gln Leu Thr Ala Glu Cys Ala Val Val Thr Leu Val Tyr Leu Glu Arg
    130                 135                 140                 
Leu Leu Thr Tyr Ala Glu Ile Asp Ile Cys Pro Ala Asn Trp Lys Arg
145                 150                 155                 160 
Ile Val Leu Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Asp Asp Gln
                165                 170                 175     
Ala Val Trp Asn Val Asp Tyr Cys Gln Ile Leu Lys Asp Ile Thr Val
            180                 185                 190         
Glu Asp Met Ser Glu Leu Glu Arg Gln Phe Leu Glu Leu Leu Gln Phe
        195                 200                 205             
Asn Ile Asn Val Pro Ser Ser Val Tyr Ala Lys Tyr Tyr Phe Asp Leu
    210                 215                 220                 
Arg Ser Leu Ala Glu Ala Asn Asn Leu Ser Phe Pro Leu Glu Pro Leu
225                 230                 235                 240 
Ser Arg Glu Arg Ala His Lys Leu Glu Ala Ile Ser Arg Leu Cys Glu
                245                 250                 255     
Asp Lys Tyr Lys Asp Leu Arg Arg Ser Ala Arg Lys Arg Ser Ala Ser
            260                 265                 270         
Ala Asp Asn Leu Thr Leu Pro Arg Trp Ser Pro Ala Ile Ile Ser
        275                 280                 285         


<210> 7241
<211> 122
<212> PRT
<213> Homo sapiens

<400> 7241
Met Pro Asn Thr Thr Val Tyr Arg Arg Val Asp Ser Val Phe Ser Val
 1               5                  10                  15      
Arg Thr Gly Gly Trp Ile Ser Leu Ser Pro Leu Gly Gly Ile Arg Ser
            20                  25                  30          
Lys Gly Ala Ile Ala Pro Pro Glu Val Thr Val Pro Ala Gln Asn Thr
        35                  40                  45              
Ser Leu Gly Pro Lys Lys Ser Phe Phe Phe Gln Ala Leu Gly Ile Thr
    50                  55                  60                  
Thr Lys Ile Ser Arg Val Thr Ile Gly Ile Leu Ser Asp Val Gln Leu
65                  70                  75                  80  
Met Arg Thr Gly Asp Lys Leu Glu Ala Ser Glu Ala Thr Leu Leu Asn
                85                  90                  95      
Met Leu Asn Thr Ala Gln Leu Phe Ser Phe Gly Leu Ile Ile Lys Arg
            100                 105                 110         
Val Phe Asn Asn Ser Ser Ile Ser His Pro
        115                 120         


<210> 7242
<211> 1704
<212> PRT
<213> Homo sapiens

<400> 7242
Met Ser Ser Val Ser Glu Val Asn Val Asp Ile Lys Asp Phe Leu Met
 1               5                  10                  15      
Ser Ile Asn Leu Glu Gln Tyr Leu Leu His Phe His Glu Ser Gly Phe
            20                  25                  30          
Thr Thr Val Lys Asp Cys Ala Ala Ile Asn Asp Ser Leu Leu Gln Lys
        35                  40                  45              
Ile Gly Ile Ser Pro Thr Gly His Arg Arg Arg Ile Leu Lys Gln Leu
    50                  55                  60                  
Gln Ile Ile Leu Ser Lys Met Gln Asp Ile Pro Ile Tyr Ala Asn Val
65                  70                  75                  80  
His Lys Thr Lys Lys Asn Asp Asp Pro Ser Lys Asp Tyr His Val Pro
                85                  90                  95      
Ser Ser Asp Gln Asn Ile Cys Ile Glu Leu Ser Asn Ser Gly Ser Val
            100                 105                 110         
Gln Thr Ser Ser Pro Pro Gln Leu Glu Thr Val Arg Lys Asn Leu Glu
        115                 120                 125             
Asp Ser Asp Ala Ser Val Glu Arg Ser Gln Tyr Pro Gln Ser Asp Asp
    130                 135                 140                 
Lys Leu Ser Pro Pro Lys Arg Asp Phe Pro Thr Ala Glu Glu Pro His
145                 150                 155                 160 
Leu Asn Leu Gly Ser Leu Asn Asp Ser Leu Phe Gly Ser Asp Asn Ile
                165                 170                 175     
Lys Ile Glu Ser Leu Ile Thr Lys Lys Thr Val Asp His Thr Val Glu
            180                 185                 190         
Glu Gln Gln Thr Glu Lys Val Lys Leu Ile Thr Glu Asn Leu Ser Lys
        195                 200                 205             
Leu Pro Asn Ala Asp Ser Glu Cys Leu Ser Phe Val Gly Cys Ser Thr
    210                 215                 220                 
Ser Gly Ile Asn Ser Gly Asn Gly Thr Asn Gly Leu Leu Glu Gly Ser
225                 230                 235                 240 
Pro Pro Ser Pro Phe Phe Lys Phe Gln Gly Glu Met Ile Val Asn Asp
                245                 250                 255     
Leu Tyr Val Pro Ser Ser Pro Ile Leu Ala Pro Val Arg Ser Arg Ser
            260                 265                 270         
Lys Leu Val Ser Arg Pro Ser Arg Ser Phe Leu Leu Arg His Arg Pro
        275                 280                 285             
Val Pro Glu Ile Pro Gly Ser Thr Lys Gly Val Ser Gly Ser Tyr Phe
    290                 295                 300                 
Arg Glu Arg Arg Asn Val Ala Thr Ser Thr Glu Lys Ser Val Ala Trp
305                 310                 315                 320 
Gln Asn Ser Asn Glu Glu Asn Ser Ser Ser Ile Phe Pro Tyr Gly Glu
                325                 330                 335     
Thr Phe Leu Phe Gln Arg Leu Glu Asn Ser Lys Lys Arg Ser Ile Lys
            340                 345                 350         
Asn Glu Phe Leu Thr Gln Gly Glu Ala Leu Lys Gly Glu Ala Ala Thr
        355                 360                 365             
Ala Thr Asn Ser Phe Ile Ile Lys Ser Ser Ile Tyr Asp Asn Arg Lys
    370                 375                 380                 
Glu Lys Ile Ser Glu Asp Lys Val Glu Asp Ile Trp Ile Pro Arg Glu
385                 390                 395                 400 
Asp Lys Asn Asn Phe Leu Ile Asp Thr Ala Ser Glu Ser Glu Tyr Ser
                405                 410                 415     
Thr Val Glu Glu Cys Phe Gln Ser Leu Arg Arg Lys Asn Ser Lys Ala
            420                 425                 430         
Ser Lys Ser Arg Thr Gln Lys Ala Leu Ile Leu Asp Ser Val Asn Arg
        435                 440                 445             
His Ser Tyr Pro Leu Ser Ser Thr Ser Gly Asn Ala Asp Ser Ser Ala
    450                 455                 460                 
Val Ser Ser Gln Ala Ile Ser Pro Tyr Ala Cys Phe Tyr Gly Ala Ser
465                 470                 475                 480 
Ala Lys Lys Val Lys Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly
                485                 490                 495     
Lys Arg Met Phe Gln Lys Arg Trp Val Lys Phe Asp Gly Leu Ser Ile
            500                 505                 510         
Ser Tyr Tyr Asn Asn Glu Lys Glu Met Tyr Ser Lys Gly Ile Ile Pro
        515                 520                 525             
Leu Ser Ala Val Ser Thr Val Arg Val Gln Gly Asp Asn Lys Phe Glu
    530                 535                 540                 
Val Val Thr Thr Gln Arg Thr Phe Val Phe Arg Val Glu Lys Glu Glu
545                 550                 555                 560 
Glu Arg Asn Asp Trp Ile Ser Ile Leu Leu Asn Ala Leu Lys Ser Gln
                565                 570                 575     
Ser Leu Thr Ser Gln Ser Gln Ala Val Val Thr Pro Glu Lys Cys Gly
            580                 585                 590         
Tyr Leu Glu Leu Arg Gly Tyr Lys Ala Lys Ile Phe Thr Val Leu Ser
        595                 600                 605             
Gly Asn Ser Val Trp Leu Cys Lys Asn Glu Gln Asp Phe Lys Ser Gly
    610                 615                 620                 
Leu Gly Ile Thr Ile Ile Pro Met Asn Val Ala Asn Val Lys Gln Val
625                 630                 635                 640 
Asp Arg Thr Val Lys Gln Ser Phe Glu Ile Ile Thr Pro Tyr Arg Ser
                645                 650                 655     
Phe Ser Phe Thr Ala Glu Thr Glu Lys Glu Lys Gln Asp Trp Ile Glu
            660                 665                 670         
Ala Val Gln Gln Ser Ile Ala Glu Thr Leu Ser Asp Tyr Glu Val Ala
        675                 680                 685             
Glu Lys Ile Trp Phe Asn Glu Ser Asn Arg Ser Cys Ala Asp Cys Lys
    690                 695                 700                 
Ala Pro Asp Pro Asp Trp Ala Ser Ile Asn Leu Cys Val Val Ile Cys
705                 710                 715                 720 
Lys Lys Cys Ala Gly Gln His Arg Ser Leu Gly Pro Lys Asp Ser Lys
                725                 730                 735     
Val Arg Ser Leu Lys Met Asp Ala Ser Ile Trp Ser Asn Glu Leu Ile
            740                 745                 750         
Glu Leu Phe Ile Val Ile Gly Asn Lys Arg Ala Asn Asp Phe Trp Ala
        755                 760                 765             
Gly Asn Leu Gln Lys Asp Glu Glu Leu His Met Asp Ser Pro Val Glu
    770                 775                 780                 
Lys Arg Lys Asn Phe Ile Thr Gln Lys Tyr Lys Glu Gly Lys Phe Arg
785                 790                 795                 800 
Lys Thr Leu Leu Ala Ser Leu Thr Lys Glu Glu Leu Asn Lys Ala Leu
                805                 810                 815     
Cys Ala Ala Val Val Lys Pro Asp Val Leu Glu Thr Met Ala Leu Leu
            820                 825                 830         
Phe Ser Gly Ala Asp Val Met Cys Ala Thr Gly Asp Pro Val His Ser
        835                 840                 845             
Thr Pro Tyr Leu Leu Ala Lys Lys Ala Gly Gln Ser Leu Gln Met Glu
    850                 855                 860                 
Phe Leu Tyr His Asn Lys Phe Ser Asp Phe Pro Gln His Asp Ile His
865                 870                 875                 880 
Ser Glu Gly Val Leu Ser Gln Glu Ser Ser Gln Ser Thr Phe Leu Cys
                885                 890                 895     
Asp Phe Leu Tyr Gln Ala Pro Ser Ala Ala Ser Lys Leu Ser Ser Glu
            900                 905                 910         
Lys Lys Leu Leu Glu Glu Thr Asn Lys Lys Trp Cys Val Leu Glu Gly
        915                 920                 925             
Gly Phe Leu Ser Tyr Tyr Glu Asn Asp Lys Ser Thr Thr Pro Asn Gly
    930                 935                 940                 
Thr Ile Asn Ile Asn Glu Val Ile Cys Leu Ala Ile His Lys Glu Asp
945                 950                 955                 960 
Phe Tyr Leu Asn Thr Gly Pro Ile Phe Ile Phe Glu Ile Tyr Leu Pro
                965                 970                 975     
Ser Glu Arg Val Phe Leu Phe Gly Ala Glu Thr Ser Gln Ala Gln Arg
            980                 985                 990         
Lys Trp Thr Glu Ala Ile Ala Lys His Phe Val Pro Leu Phe Ala Glu
        995                 1000                1005            
Asn Leu Thr Glu Ala Asp Tyr Asp Leu Ile Gly Gln Leu Phe Tyr Lys
    1010                1015                1020                
Asp Cys His Ala Leu Asp Gln Trp Arg Lys Gly Trp Phe Ala Met Asp
1025                1030                1035                1040
Lys Ser Ser Leu His Phe Cys Leu Gln Met Gln Glu Val Gln Gly Asp
                1045                1050                1055    
Arg Met His Leu Arg Arg Leu Gln Glu Leu Thr Ile Ser Thr Met Val
            1060                1065                1070        
Gln Asn Gly Glu Lys Leu Asp Val Leu Leu Leu Val Glu Lys Gly Arg
        1075                1080                1085            
Thr Leu Tyr Ile His Gly His Thr Lys Leu Asp Phe Thr Val Trp His
    1090                1095                1100                
Thr Ala Ile Glu Lys Ala Ala Gly Thr Asp Gly Asn Ala Leu Gln Asp
1105                1110                1115                1120
Gln Gln Leu Ser Lys Asn Asp Val Pro Ile Ile Val Asn Ser Cys Ile
                1125                1130                1135    
Ala Phe Val Thr Gln Tyr Gly Leu Gly Cys Lys Tyr Ile Tyr Gln Lys
            1140                1145                1150        
Asn Gly Asp Pro Leu His Ile Ser Glu Leu Leu Glu Ser Phe Lys Lys
        1155                1160                1165            
Asp Ala Arg Ser Phe Lys Leu Arg Ala Gly Lys His Gln Leu Glu Asp
    1170                1175                1180                
Val Thr Ala Val Leu Lys Ser Phe Leu Ser Asp Ile Asp Asp Ala Leu
1185                1190                1195                1200
Leu Thr Lys Glu Leu Tyr Pro Tyr Trp Ile Ser Ala Leu Asp Thr Gln
                1205                1210                1215    
Asp Asp Lys Glu Arg Ile Lys Lys Tyr Gly Ala Phe Ile Arg Ser Leu
            1220                1225                1230        
Pro Gly Val Asn Arg Ala Thr Leu Ala Ala Ile Ile Glu His Leu Tyr
        1235                1240                1245            
Arg Val Gln Lys Cys Ser Glu Ile Asn His Met Asn Ala His Asn Leu
    1250                1255                1260                
Ala Leu Val Phe Ser Ser Cys Leu Phe Gln Thr Lys Gly Gln Thr Ser
1265                1270                1275                1280
Glu Glu Val Asn Val Ile Glu Asp Leu Ile Asn Asn Tyr Val Glu Ile
                1285                1290                1295    
Phe Glu Val Lys Glu Asp Gln Val Lys Gln Met Asp Ile Glu Asn Ser
            1300                1305                1310        
Phe Ile Thr Lys Trp Lys Asp Thr Gln Val Ser Gln Ala Gly Asp Leu
        1315                1320                1325            
Leu Ile Glu Val Tyr Val Glu Arg Lys Glu Pro Asp Cys Ser Ile Ile
    1330                1335                1340                
Ile Arg Ile Ser Pro Val Met Glu Ala Glu Glu Leu Thr Asn Asp Ile
1345                1350                1355                1360
Leu Ala Ile Lys Asn Ile Ile Pro Thr Lys Gly Asp Ile Trp Ala Thr
                1365                1370                1375    
Phe Glu Val Ile Glu Asn Glu Glu Leu Glu Arg Pro Leu His Tyr Lys
            1380                1385                1390        
Glu Asn Val Leu Glu Gln Val Leu Arg Trp Ser Ser Leu Ala Glu Pro
        1395                1400                1405            
Gly Ser Ala Tyr Leu Val Val Lys Arg Phe Leu Thr Ala Asp Thr Ile
    1410                1415                1420                
Lys His Cys Ser Asp Arg Ser Thr Leu Gly Ser Ile Lys Glu Gly Ile
1425                1430                1435                1440
Leu Lys Ile Lys Glu Glu Pro Ser Lys Ile Leu Ser Gly Asn Lys Phe
                1445                1450                1455    
Gln Asp Arg Tyr Phe Val Leu Arg Asp Gly Phe Leu Phe Leu Tyr Lys
            1460                1465                1470        
Asp Val Lys Ser Ser Lys His Asp Lys Met Phe Ser Leu Ser Ser Met
        1475                1480                1485            
Lys Phe Tyr Arg Gly Val Lys Lys Lys Met Lys Pro Pro Thr Ser Trp
    1490                1495                1500                
Gly Leu Thr Ala Tyr Ser Glu Lys His His Trp His Leu Cys Cys Asp
1505                1510                1515                1520
Ser Ser Gln Thr Gln Thr Glu Trp Met Thr Ser Ile Phe Ile Ala Gln
                1525                1530                1535    
His Glu Tyr Asp Ile Trp Pro Pro Ala Gly Lys Glu Arg Lys Arg Ser
            1540                1545                1550        
Ile Thr Lys Asn Pro Lys Ile Gly Gly Leu Pro Leu Ile Pro Ile Gln
        1555                1560                1565            
His Glu Gly Asn Ala Thr Leu Ala Arg Lys Asn Ile Glu Ser Ala Arg
    1570                1575                1580                
Ala Glu Leu Glu Arg Leu Arg Leu Ser Glu Lys Cys Asp Lys Glu Ser
1585                1590                1595                1600
Val Asp Ser Ser Leu Lys Glu Arg Ala Ser Met Val Ala His Cys Leu
                1605                1610                1615    
Glu His Lys Asp Asp Lys Leu Arg Asn Arg Pro Arg Lys His Arg Ser
            1620                1625                1630        
Phe Asn Cys Leu Glu Asp Thr Glu Pro Glu Ala Pro Leu Gly Gln Pro
        1635                1640                1645            
Lys Gly His Lys Gly Leu Lys Thr Leu Arg Lys Thr Glu Asp Arg Asn
    1650                1655                1660                
Ser Lys Ala Thr Leu Asp Ser Asp His Lys Leu Pro Ser Arg Val Ile
1665                1670                1675                1680
Glu Glu Leu Asn Val Val Leu Gln Arg Ser Arg Thr Leu Pro Lys Glu
                1685                1690                1695    
Leu Gln Asp Glu Gln Ile Leu Lys
            1700                


<210> 7243
<211> 1704
<212> PRT
<213> Homo sapiens

<400> 7243
Met Ser Ser Val Ser Glu Val Asn Val Asp Ile Lys Asp Phe Leu Met
 1               5                  10                  15      
Ser Ile Asn Leu Glu Gln Tyr Leu Leu His Phe His Glu Ser Gly Phe
            20                  25                  30          
Thr Thr Val Lys Asp Cys Ala Ala Ile Asn Asp Ser Leu Leu Gln Lys
        35                  40                  45              
Ile Gly Ile Ser Pro Thr Gly His Arg Arg Arg Ile Leu Lys Gln Leu
    50                  55                  60                  
Gln Ile Ile Leu Ser Lys Met Gln Asp Ile Pro Ile Tyr Ala Asn Val
65                  70                  75                  80  
His Lys Thr Lys Lys Asn Asp Asp Pro Ser Lys Asp Tyr His Val Pro
                85                  90                  95      
Ser Ser Asp Gln Asn Ile Cys Ile Glu Leu Ser Asn Ser Gly Ser Val
            100                 105                 110         
Gln Thr Ser Ser Pro Pro Gln Leu Glu Thr Val Arg Lys Asn Leu Glu
        115                 120                 125             
Asp Ser Asp Ala Ser Val Glu Arg Ser Gln Tyr Pro Gln Ser Asp Asp
    130                 135                 140                 
Lys Leu Ser Pro Pro Lys Arg Asp Phe Pro Thr Ala Glu Glu Pro His
145                 150                 155                 160 
Leu Asn Leu Gly Ser Leu Asn Asp Ser Leu Phe Gly Ser Asp Asn Ile
                165                 170                 175     
Lys Ile Glu Ser Leu Ile Thr Lys Lys Thr Val Asp His Thr Val Glu
            180                 185                 190         
Glu Gln Gln Thr Glu Lys Val Lys Leu Ile Thr Glu Asn Leu Ser Lys
        195                 200                 205             
Leu Pro Asn Ala Asp Ser Glu Cys Leu Ser Phe Val Gly Cys Ser Thr
    210                 215                 220                 
Ser Gly Thr Asn Ser Gly Asn Gly Thr Asn Gly Leu Leu Glu Gly Ser
225                 230                 235                 240 
Pro Pro Ser Pro Phe Phe Lys Phe Gln Gly Glu Met Ile Val Asn Asp
                245                 250                 255     
Leu Tyr Val Pro Ser Ser Pro Ile Leu Ala Pro Val Arg Ser Arg Ser
            260                 265                 270         
Lys Leu Val Ser Arg Pro Ser Arg Ser Phe Leu Leu Arg His Arg Pro
        275                 280                 285             
Val Pro Glu Ile Pro Gly Ser Thr Lys Gly Val Ser Gly Ser Tyr Phe
    290                 295                 300                 
Arg Glu Arg Arg Asn Val Ala Thr Ser Thr Glu Lys Ser Val Ala Trp
305                 310                 315                 320 
Gln Asn Ser Asn Glu Glu Asn Ser Ser Ser Ile Phe Pro Tyr Gly Glu
                325                 330                 335     
Thr Phe Leu Phe Gln Arg Leu Glu Asn Ser Lys Lys Arg Ser Ile Lys
            340                 345                 350         
Asn Glu Phe Leu Thr Gln Gly Glu Ala Leu Lys Gly Glu Ala Ala Thr
        355                 360                 365             
Ala Thr Asn Ser Phe Ile Ile Lys Ser Ser Ile Tyr Asp Asn Arg Lys
    370                 375                 380                 
Glu Lys Ile Ser Glu Asp Lys Val Glu Asp Ile Trp Ile Pro Arg Glu
385                 390                 395                 400 
Asp Lys Asn Asn Phe Leu Ile Asp Thr Ala Ser Glu Ser Glu Tyr Ser
                405                 410                 415     
Thr Val Glu Glu Cys Phe Gln Ser Leu Arg Arg Lys Asn Ser Lys Ala
            420                 425                 430         
Ser Lys Ser Arg Thr Gln Lys Ala Leu Ile Leu Asp Ser Val Asn Arg
        435                 440                 445             
His Ser Tyr Pro Leu Ser Ser Thr Ser Gly Asn Ala Asp Ser Ser Ala
    450                 455                 460                 
Val Ser Ser Gln Ala Ile Ser Pro Tyr Ala Cys Phe Tyr Gly Ala Ser
465                 470                 475                 480 
Ala Lys Lys Val Lys Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly
                485                 490                 495     
Lys Arg Met Phe Gln Lys Arg Trp Val Lys Phe Asp Gly Leu Ser Ile
            500                 505                 510         
Ser Tyr Tyr Asn Asn Glu Lys Glu Met Tyr Ser Lys Gly Ile Ile Pro
        515                 520                 525             
Leu Ser Ala Ile Ser Thr Val Arg Val Gln Gly Asp Asn Lys Phe Glu
    530                 535                 540                 
Val Val Thr Thr Gln Arg Thr Phe Val Phe Arg Val Glu Lys Glu Glu
545                 550                 555                 560 
Glu Arg Asn Asp Trp Ile Ser Ile Leu Leu Asn Ala Leu Lys Ser Gln
                565                 570                 575     
Ser Leu Thr Ser Gln Ser Gln Ala Val Val Thr Pro Glu Lys Cys Gly
            580                 585                 590         
Tyr Leu Glu Leu Arg Gly Tyr Lys Ala Lys Ile Phe Thr Val Leu Ser
        595                 600                 605             
Gly Asn Ser Val Trp Leu Cys Lys Asn Glu Gln Asp Phe Lys Ser Gly
    610                 615                 620                 
Leu Gly Ile Thr Ile Ile Pro Met Asn Val Ala Asn Val Lys Gln Val
625                 630                 635                 640 
Asp Arg Thr Val Lys Gln Ser Phe Glu Ile Ile Thr Pro Tyr Arg Ser
                645                 650                 655     
Phe Ser Phe Thr Ala Glu Thr Glu Lys Glu Lys Gln Asp Trp Ile Glu
            660                 665                 670         
Ala Val Gln Gln Ser Ile Ala Glu Thr Leu Ser Asp Tyr Glu Val Ala
        675                 680                 685             
Glu Lys Ile Trp Phe Asn Glu Ser Asn Arg Ser Cys Ala Asp Cys Lys
    690                 695                 700                 
Ala Pro Asp Pro Asp Trp Ala Ser Ile Asn Leu Cys Val Val Ile Cys
705                 710                 715                 720 
Lys Lys Cys Ala Gly Gln His Arg Ser Leu Gly Pro Lys Asp Ser Lys
                725                 730                 735     
Val Arg Ser Leu Lys Met Asp Ala Ser Ile Trp Ser Asn Glu Leu Ile
            740                 745                 750         
Glu Leu Phe Ile Val Ile Gly Asn Lys Arg Ala Asn Asp Phe Trp Ala
        755                 760                 765             
Gly Asn Leu Gln Lys Asp Glu Glu Leu His Met Asp Ser Pro Val Glu
    770                 775                 780                 
Lys Arg Lys Asn Phe Ile Thr Gln Lys Tyr Lys Glu Gly Lys Phe Arg
785                 790                 795                 800 
Lys Thr Leu Leu Ala Ser Leu Thr Lys Glu Glu Leu Asn Lys Ala Leu
                805                 810                 815     
Cys Ala Ala Val Val Lys Pro Asp Val Leu Glu Thr Met Ala Leu Leu
            820                 825                 830         
Phe Ser Gly Ala Asp Val Met Cys Ala Thr Gly Asp Pro Val His Ser
        835                 840                 845             
Thr Pro Tyr Leu Leu Ala Lys Lys Ala Gly Gln Ser Leu Gln Met Glu
    850                 855                 860                 
Phe Leu Tyr His Asn Lys Phe Ser Asp Phe Pro Gln His Asp Ile His
865                 870                 875                 880 
Ser Glu Gly Val Leu Ser Gln Glu Ser Ser Gln Ser Thr Phe Leu Cys
                885                 890                 895     
Asp Phe Leu Tyr Gln Ala Pro Ser Ala Ala Ser Lys Leu Ser Ser Glu
            900                 905                 910         
Lys Lys Leu Leu Glu Glu Thr Asn Lys Lys Trp Cys Val Leu Glu Gly
        915                 920                 925             
Gly Phe Leu Ser Tyr Tyr Glu Asn Asp Lys Ser Thr Thr Pro Asn Gly
    930                 935                 940                 
Thr Ile Asn Ile Asn Glu Val Ile Cys Leu Ala Ile His Lys Glu Asp
945                 950                 955                 960 
Phe Tyr Leu Asn Thr Gly Pro Ile Phe Ile Phe Glu Ile Tyr Leu Pro
                965                 970                 975     
Ser Glu Arg Val Phe Leu Phe Gly Ala Glu Thr Ser Gln Ala Gln Arg
            980                 985                 990         
Lys Trp Thr Glu Ala Ile Ala Lys His Phe Val Pro Leu Phe Ala Glu
        995                 1000                1005            
Asn Leu Thr Glu Ala Asp Tyr Asp Leu Ile Gly Gln Leu Phe Tyr Lys
    1010                1015                1020                
Asp Cys His Ala Leu Asp Gln Trp Arg Lys Gly Trp Phe Ala Met Asp
1025                1030                1035                1040
Lys Ser Ser Leu His Phe Cys Leu Gln Met Gln Glu Val Gln Gly Asp
                1045                1050                1055    
Arg Met His Leu Arg Arg Leu Gln Glu Leu Thr Ile Ser Thr Met Val
            1060                1065                1070        
Gln Asn Gly Glu Lys Leu Asp Val Leu Leu Leu Val Glu Lys Gly Arg
        1075                1080                1085            
Thr Leu Tyr Ile His Gly His Thr Lys Leu Asp Phe Thr Val Trp His
    1090                1095                1100                
Thr Ala Ile Glu Lys Ala Ala Gly Thr Asp Gly Asn Ala Leu Gln Asp
1105                1110                1115                1120
Gln Gln Leu Ser Lys Asn Asp Val Pro Ile Ile Val Asn Ser Cys Ile
                1125                1130                1135    
Ala Phe Val Thr Gln Tyr Gly Leu Gly Cys Lys Tyr Ile Tyr Gln Lys
            1140                1145                1150        
Asn Gly Asp Pro Leu His Ile Ser Glu Leu Leu Glu Ser Phe Lys Lys
        1155                1160                1165            
Asp Ala Arg Ser Phe Lys Leu Arg Ala Gly Lys His Gln Leu Glu Asp
    1170                1175                1180                
Val Thr Ala Val Leu Lys Ser Phe Leu Ser Asp Ile Asp Asp Ala Leu
1185                1190                1195                1200
Leu Thr Lys Glu Leu Tyr Pro Tyr Trp Ile Ser Ala Leu Asp Thr Gln
                1205                1210                1215    
Asp Asp Lys Glu Arg Ile Lys Lys Tyr Gly Ala Phe Ile Arg Ser Leu
            1220                1225                1230        
Pro Gly Val Asn Arg Ala Thr Leu Ala Ala Ile Ile Glu His Leu Tyr
        1235                1240                1245            
Arg Val Gln Lys Cys Ser Glu Ile Asn His Met Asn Ala His Asn Leu
    1250                1255                1260                
Ala Leu Val Phe Ser Ser Cys Leu Phe Gln Thr Lys Gly Gln Thr Ser
1265                1270                1275                1280
Glu Glu Val Asn Val Ile Glu Asp Leu Ile Asn Asn Tyr Val Glu Ile
                1285                1290                1295    
Phe Glu Val Lys Glu Asp Gln Val Lys Gln Met Asp Ile Glu Asn Ser
            1300                1305                1310        
Phe Ile Thr Lys Trp Lys Asp Thr Gln Val Ser Gln Ala Gly Asp Leu
        1315                1320                1325            
Leu Ile Glu Val Tyr Val Glu Arg Lys Glu Pro Asp Cys Ser Ile Ile
    1330                1335                1340                
Ile Arg Ile Ser Pro Val Met Glu Ala Glu Glu Leu Thr Asn Asp Ile
1345                1350                1355                1360
Leu Ala Ile Lys Asn Ile Ile Pro Thr Lys Gly Asp Ile Trp Ala Thr
                1365                1370                1375    
Phe Glu Val Ile Glu Asn Glu Glu Leu Glu Arg Pro Leu His Tyr Lys
            1380                1385                1390        
Glu Asn Val Leu Glu Gln Val Leu Arg Trp Ser Ser Leu Ala Glu Pro
        1395                1400                1405            
Gly Ser Ala Tyr Leu Val Val Lys Arg Phe Leu Thr Ala Asp Thr Ile
    1410                1415                1420                
Lys His Cys Ser Asp Arg Ser Thr Leu Gly Ser Ile Lys Glu Gly Ile
1425                1430                1435                1440
Leu Lys Ile Lys Glu Glu Pro Ser Lys Ile Leu Ser Gly Asn Lys Phe
                1445                1450                1455    
Gln Asp Arg Tyr Phe Val Leu Arg Asp Gly Phe Leu Phe Leu Tyr Lys
            1460                1465                1470        
Asp Val Lys Ser Ser Lys His Asp Lys Met Phe Ser Leu Ser Ser Met
        1475                1480                1485            
Lys Phe Tyr Arg Gly Val Lys Lys Lys Met Lys Pro Pro Thr Ser Trp
    1490                1495                1500                
Gly Leu Thr Ala Tyr Ser Glu Lys His His Trp His Leu Cys Cys Asp
1505                1510                1515                1520
Ser Ser Gln Thr Gln Thr Glu Trp Met Thr Ser Ile Phe Ile Ala Gln
                1525                1530                1535    
His Glu Tyr Asp Ile Trp Pro Pro Ala Gly Lys Glu Arg Lys Arg Ser
            1540                1545                1550        
Ile Thr Lys Asn Pro Lys Ile Gly Gly Leu Pro Leu Ile Pro Ile Gln
        1555                1560                1565            
His Glu Gly Asn Ala Thr Leu Ala Arg Lys Asn Ile Glu Ser Ala Arg
    1570                1575                1580                
Ala Glu Leu Glu Arg Leu Arg Leu Ser Glu Lys Cys Asp Lys Glu Ser
1585                1590                1595                1600
Val Asp Ser Ser Leu Lys Glu Arg Ala Ser Met Val Ala His Cys Leu
                1605                1610                1615    
Glu His Lys Asp Asp Lys Leu Arg Asn Arg Pro Arg Lys His Arg Ser
            1620                1625                1630        
Phe Asn Cys Leu Glu Asp Thr Glu Pro Glu Ala Pro Leu Gly Gln Pro
        1635                1640                1645            
Lys Gly His Lys Gly Leu Lys Thr Leu Arg Lys Thr Glu Asp Arg Asn
    1650                1655                1660                
Ser Lys Ala Thr Leu Asp Ser Asp His Lys Leu Pro Ser Arg Val Ile
1665                1670                1675                1680
Glu Glu Leu Asn Val Val Leu Gln Arg Ser Arg Thr Leu Pro Lys Glu
                1685                1690                1695    
Leu Gln Asp Glu Gln Ile Leu Lys
            1700                


<210> 7244
<211> 893
<212> PRT
<213> Homo sapiens

<400> 7244
Met Thr Ala Glu Glu Thr Val Asn Val Lys Glu Val Glu Ile Ile Lys
 1               5                  10                  15      
Leu Ile Leu Asp Phe Leu Asn Ser Lys Lys Leu His Ile Ser Met Leu
            20                  25                  30          
Ala Leu Glu Lys Glu Ser Gly Val Ile Asn Gly Leu Phe Ser Asp Asp
        35                  40                  45              
Met Leu Phe Leu Arg Phe Arg Tyr Ile Ile Leu Lys Gln Lys Phe Leu
    50                  55                  60                  
Glu Ala Leu Cys Val Asn Asn Ala Met Ser Ala Glu Asp Glu Pro Gln
65                  70                  75                  80  
His Leu Glu Phe Thr Met Gln Glu Ala Val Gln Cys Leu His Ala Leu
                85                  90                  95      
Glu Glu Tyr Cys Pro Ser Lys Asp Asp Tyr Ser Lys Leu Cys Leu Leu
            100                 105                 110         
Leu Thr Leu Pro Arg Leu Thr Asn His Ala Glu Phe Lys Asp Trp Asn
        115                 120                 125             
Pro Ser Thr Ala Arg Val His Cys Phe Glu Glu Ala Cys Val Met Val
    130                 135                 140                 
Ala Glu Phe Ile Pro Ala Asp Arg Lys Leu Ser Glu Ala Gly Phe Lys
145                 150                 155                 160 
Ala Ser Asn Asn Arg Leu Phe Gln Leu Val Met Lys Gly Leu Leu Tyr
                165                 170                 175     
Glu Cys Cys Val Glu Phe Cys Gln Ser Lys Ala Thr Gly Glu Glu Ile
            180                 185                 190         
Thr Glu Ser Glu Val Leu Leu Gly Ile Asp Leu Leu Cys Gly Asn Gly
        195                 200                 205             
Cys Asp Asp Leu Asp Leu Ser Leu Leu Ser Trp Leu Gln Asn Leu Pro
    210                 215                 220                 
Ser Ser Val Phe Ser Cys Ala Phe Glu Gln Lys Met Leu Asn Ile His
225                 230                 235                 240 
Val Asp Lys Leu Leu Lys Pro Thr Lys Ala Ala Tyr Ala Asp Leu Leu
                245                 250                 255     
Thr Pro Leu Ile Ser Lys Leu Ser Pro Tyr Pro Ser Ser Gln Met Arg
            260                 265                 270         
Arg Pro Gln Ser Ala Asp Ala Tyr Met Thr Arg Ser Leu Asn Pro Ala
        275                 280                 285             
Leu Asp Gly Leu Thr Cys Gly Leu Thr Ser His Asp Lys Arg Ile Ser
    290                 295                 300                 
Asp Leu Gly Asn Lys Thr Ser Pro Met Ser His Ser Phe Ala Asn Phe
305                 310                 315                 320 
His Tyr Pro Gly Val Gln Asn Leu Ser Arg Ser Leu Met Leu Glu Asn
                325                 330                 335     
Thr Glu Cys His Cys Ile Tyr Glu Glu Ser Pro Glu Arg Asp Thr Pro
            340                 345                 350         
Val Asp Ala Gln Arg Pro Ile Gly Ser Glu Ile Leu Gly Gln Ser Ser
        355                 360                 365             
Val Ser Glu Lys Glu Pro Ala Asn Gly Ala Gln Asn Pro Gly Pro Ala
    370                 375                 380                 
Lys Gln Glu Lys Asn Glu Leu Arg Asp Ser Thr Glu Gln Phe Gln Glu
385                 390                 395                 400 
Tyr Tyr Arg Gln Arg Leu Arg Tyr Gln Gln His Leu Glu Gln Lys Glu
                405                 410                 415     
Gln Gln Arg Gln Ile Tyr Gln Gln Met Leu Leu Glu Gly Gly Val Asn
            420                 425                 430         
Gln Glu Asp Gly Pro Asp Gln Gln Gln Asn Leu Thr Glu Gln Phe Leu
        435                 440                 445             
Asn Arg Ser Ile Gln Lys Leu Gly Glu Leu Asn Ile Gly Met Asp Gly
    450                 455                 460                 
Leu Gly Asn Glu Val Ser Ala Leu Asn Gln Gln Cys Asn Gly Ser Lys
465                 470                 475                 480 
Gly Asn Gly Ser Asn Gly Ser Ser Val Thr Ser Phe Thr Thr Pro Pro
                485                 490                 495     
Gln Asp Ser Ser Gln Arg Leu Thr His Asp Ala Ser Asn Ile His Thr
            500                 505                 510         
Ser Thr Pro Arg Asn Pro Gly Ser Thr Asn His Ile Pro Phe Leu Glu
        515                 520                 525             
Glu Ser Pro Cys Gly Ser Gln Ile Ser Ser Glu His Ser Val Ile Lys
    530                 535                 540                 
Pro Pro Leu Gly Asp Ser Pro Gly Ser Leu Ser Arg Ser Lys Gly Glu
545                 550                 555                 560 
Glu Asp Asp Lys Ser Lys Lys Gln Phe Val Cys Ile Asn Ile Leu Glu
                565                 570                 575     
Asp Thr Gln Ala Val Arg Ala Val Ala Phe His Pro Ala Gly Gly Leu
            580                 585                 590         
Tyr Ala Val Gly Ser Asn Ser Lys Thr Leu Arg Val Cys Ala Tyr Pro
        595                 600                 605             
Asp Val Ile Asp Pro Ser Ala His Glu Thr Pro Lys Gln Pro Val Val
    610                 615                 620                 
Arg Phe Lys Arg Asn Lys His His Lys Gly Ser Ile Tyr Cys Val Ala
625                 630                 635                 640 
Trp Ser Pro Cys Gly Gln Leu Leu Ala Thr Gly Ser Asn Asp Lys Tyr
                645                 650                 655     
Val Lys Val Leu Pro Phe Asn Ala Glu Thr Cys Asn Ala Thr Val Ser
            660                 665                 670         
Gly Pro Asp Leu Glu Phe Ser Met His Asp Gly Thr Ile Arg Asp Leu
        675                 680                 685             
Ala Phe Met Glu Gly Pro Glu Ser Gly Gly Ala Ile Leu Ile Ser Ala
    690                 695                 700                 
Gly Ala Gly Asp Cys Asn Ile Tyr Thr Thr Asp Cys Gln Arg Gly Gln
705                 710                 715                 720 
Gly Leu His Ala Leu Ser Gly His Thr Gly His Ile Leu Ala Leu Tyr
                725                 730                 735     
Thr Trp Ser Gly Trp Met Ile Ala Ser Gly Ser Gln Asp Lys Thr Val
            740                 745                 750         
Arg Phe Trp Asp Leu Arg Val Pro Ser Cys Val Arg Val Val Gly Thr
        755                 760                 765             
Thr Phe His Gly Thr Gly Ser Ala Val Ala Ser Val Ala Val Asp Pro
    770                 775                 780                 
Ser Gly Arg Leu Leu Ala Thr Gly Gln Glu Asp Ser Ser Cys Met Leu
785                 790                 795                 800 
Tyr Asp Ile Arg Gly Gly Arg Met Val Gln Ser Tyr His Pro His Ser
                805                 810                 815     
Ser Asp Val Arg Ser Val Arg Phe Ser Pro Gly Ala His Tyr Leu Leu
            820                 825                 830         
Thr Gly Ser Tyr Asp Met Lys Ile Lys Val Thr Asp Leu Gln Gly Asp
        835                 840                 845             
Leu Thr Lys Gln Leu Pro Ile Met Val Val Gly Glu His Lys Asp Lys
    850                 855                 860                 
Val Ile Gln Cys Arg Trp His Thr Gln Asp Leu Ser Phe Leu Ser Ser
865                 870                 875                 880 
Ser Ala Asp Arg Thr Val Thr Leu Trp Thr Tyr Asn Gly
                885                 890             


<210> 7245
<211> 920
<212> PRT
<213> Homo sapiens

<400> 7245
Met Thr Ala Glu Glu Thr Val Asn Val Lys Glu Val Glu Ile Ile Lys
 1               5                  10                  15      
Leu Ile Leu Asp Phe Leu Asn Ser Lys Lys Leu His Ile Ser Met Leu
            20                  25                  30          
Ala Leu Glu Lys Glu Ser Gly Val Ile Asn Gly Leu Phe Ser Asp Asp
        35                  40                  45              
Met Leu Phe Leu Arg Gln Leu Ile Leu Asp Gly Gln Trp Asp Glu Val
    50                  55                  60                  
Leu Gln Phe Ile Gln Pro Leu Glu Cys Met Glu Lys Phe Asp Lys Lys
65                  70                  75                  80  
Arg Phe Arg Tyr Ile Ile Leu Lys Gln Lys Phe Leu Glu Ala Leu Cys
                85                  90                  95      
Val Asn Asn Ala Met Ser Ala Glu Asp Glu Pro Gln His Leu Glu Phe
            100                 105                 110         
Thr Met Gln Glu Ala Val Gln Cys Leu His Ala Leu Glu Glu Tyr Cys
        115                 120                 125             
Pro Ser Lys Asp Asp Tyr Ser Lys Leu Cys Leu Leu Leu Thr Leu Pro
    130                 135                 140                 
Arg Leu Thr Asn His Ala Glu Phe Lys Asp Trp Asn Pro Ser Thr Ala
145                 150                 155                 160 
Arg Val His Cys Phe Glu Glu Ala Cys Val Met Val Ala Glu Phe Ile
                165                 170                 175     
Pro Ala Asp Arg Lys Leu Ser Glu Ala Gly Phe Lys Ala Ser Asn Asn
            180                 185                 190         
Arg Leu Phe Gln Leu Val Met Lys Gly Leu Leu Tyr Glu Cys Cys Val
        195                 200                 205             
Glu Phe Cys Gln Ser Lys Ala Thr Gly Glu Glu Ile Thr Glu Ser Glu
    210                 215                 220                 
Val Leu Leu Gly Ile Asp Leu Leu Cys Gly Asn Gly Cys Asp Asp Leu
225                 230                 235                 240 
Asp Leu Ser Leu Leu Ser Trp Leu Gln Asn Leu Pro Ser Ser Val Phe
                245                 250                 255     
Ser Cys Ala Phe Glu Gln Lys Met Leu Asn Ile His Val Asp Lys Leu
            260                 265                 270         
Leu Lys Pro Thr Lys Ala Ala Tyr Ala Asp Leu Leu Thr Pro Leu Ile
        275                 280                 285             
Ser Lys Leu Ser Pro Tyr Pro Ser Ser Pro Met Arg Arg Pro Gln Ser
    290                 295                 300                 
Ala Asp Ala Tyr Met Thr Arg Ser Leu Asn Pro Ala Leu Asp Gly Leu
305                 310                 315                 320 
Thr Cys Gly Leu Thr Ser His Asp Lys Arg Ile Ser Asp Leu Gly Asn
                325                 330                 335     
Lys Thr Ser Pro Met Ser His Ser Phe Ala Asn Phe His Tyr Pro Gly
            340                 345                 350         
Val Gln Asn Leu Ser Arg Ser Leu Met Leu Glu Asn Thr Glu Cys His
        355                 360                 365             
Ser Ile Tyr Glu Glu Ser Pro Glu Arg Ser Asp Thr Pro Val Asp Ala
    370                 375                 380                 
Gln Arg Pro Ile Gly Ser Glu Ile Leu Gly Gln Ser Ser Val Ser Glu
385                 390                 395                 400 
Lys Glu Pro Ala Asn Gly Ala Gln Asn Pro Gly Pro Ala Lys Gln Glu
                405                 410                 415     
Lys Asn Glu Leu Arg Asp Ser Thr Glu Gln Phe Gln Glu Tyr Tyr Arg
            420                 425                 430         
Gln Arg Leu Arg Tyr Gln Gln His Leu Glu Gln Lys Glu Gln Gln Arg
        435                 440                 445             
Gln Ile Tyr Gln Gln Met Leu Leu Glu Gly Gly Val Asn Gln Glu Asp
    450                 455                 460                 
Gly Pro Asp Gln Gln Gln Asn Leu Thr Glu Gln Phe Leu Asn Arg Ser
465                 470                 475                 480 
Ile Gln Lys Leu Gly Glu Leu Asn Ile Gly Met Asp Gly Leu Gly Asn
                485                 490                 495     
Glu Val Ser Ala Leu Asn Gln Gln Cys Asn Gly Ser Lys Gly Asn Gly
            500                 505                 510         
Ser Asn Gly Ser Ser Val Thr Ser Phe Thr Thr Pro Pro Gln Asp Ser
        515                 520                 525             
Ser Gln Arg Leu Thr His Asp Ala Ser Asn Ile His Thr Ser Thr Pro
    530                 535                 540                 
Arg Asn Pro Gly Ser Thr Asn His Ile Pro Phe Leu Glu Glu Ser Pro
545                 550                 555                 560 
Cys Gly Ser Gln Ile Ser Ser Glu His Ser Val Ile Lys Pro Pro Leu
                565                 570                 575     
Gly Asp Ser Pro Gly Ser Leu Ser Arg Ser Lys Gly Glu Glu Asp Asp
            580                 585                 590         
Lys Ser Lys Lys Gln Phe Val Cys Ile Asn Ile Leu Glu Asp Thr Gln
        595                 600                 605             
Ala Val Arg Ala Val Ala Phe His Pro Ala Gly Gly Leu Tyr Ala Val
    610                 615                 620                 
Gly Ser Asn Ser Lys Thr Leu Arg Val Cys Ala Tyr Pro Asp Val Ile
625                 630                 635                 640 
Asp Pro Ser Ala His Glu Thr Pro Lys Gln Pro Val Val Arg Phe Lys
                645                 650                 655     
Arg Asn Lys His His Lys Gly Ser Ile Tyr Cys Val Ala Trp Ser Pro
            660                 665                 670         
Cys Gly Gln Leu Leu Ala Thr Gly Ser Asn Asp Lys Tyr Val Lys Val
        675                 680                 685             
Leu Pro Phe Asn Ala Glu Thr Cys Asn Ala Thr Gly Pro Asp Leu Glu
    690                 695                 700                 
Phe Ser Met His Asp Gly Thr Ile Arg Asp Leu Ala Phe Met Glu Gly
705                 710                 715                 720 
Pro Glu Ser Gly Gly Ala Ile Leu Ile Ser Ala Gly Ala Gly Asp Cys
                725                 730                 735     
Asn Ile Tyr Thr Thr Asp Cys Gln Arg Gly Gln Gly Leu His Ala Leu
            740                 745                 750         
Ser Gly His Thr Gly His Ile Leu Ala Leu Tyr Thr Trp Ser Gly Trp
        755                 760                 765             
Met Ile Ala Ser Gly Ser Gln Asp Lys Thr Val Gly Phe Trp Asp Leu
    770                 775                 780                 
Arg Val Pro Ser Cys Ala Arg Val Val Gly Thr Thr Phe His Gly Thr
785                 790                 795                 800 
Gly Ser Ala Val Ala Ser Val Ala Val Asp Pro Ser Gly Arg Leu Leu
                805                 810                 815     
Ala Thr Gly Gln Glu Asp Ser Ser Cys Met Leu Tyr Asp Ile Arg Gly
            820                 825                 830         
Gly Arg Met Val Gln Ser Tyr His Pro His Ser Ser Asp Val Arg Ser
        835                 840                 845             
Val Arg Phe Ser Pro Gly Ala His Tyr Leu Leu Thr Gly Ser Tyr Asp
    850                 855                 860                 
Met Lys Ile Lys Val Thr Asp Leu Gln Gly Asp Leu Thr Lys Gln Leu
865                 870                 875                 880 
Pro Ile Met Val Val Gly Glu His Lys Asp Lys Val Ile Gln Cys Arg
                885                 890                 895     
Trp His Thr Gln Asp Leu Ser Phe Leu Ser Ser Ser Ala Asp Arg Thr
            900                 905                 910         
Val Thr Leu Trp Thr Tyr Asn Gly
        915                 920 


<210> 7246
<211> 3683
<212> PRT
<213> Homo sapiens

<400> 7246
Met Leu Met Ser Gly Lys Lys Asp Arg Asn Asn Thr Glu Val Glu Arg
 1               5                  10                  15      
Phe Ser Glu Val Phe Cys Ser Val Gln Arg Leu Ser Gln Ala Phe Ile
            20                  25                  30          
Asp Leu His Ser Ala Gly Asn Met Leu Phe Arg Thr Trp Ile Ala Met
        35                  40                  45              
Ala Tyr Cys Ser Pro Lys Gln Gly Val Ser Leu Gln Met Asp Phe Gly
    50                  55                  60                  
Leu Asp Leu Val Thr Glu Leu Lys Glu Gly Gly Asp Val Thr Glu Leu
65                  70                  75                  80  
Leu Ala Ala Leu Cys Arg Gln Met Glu His Phe Leu Asp Ser Trp Lys
                85                  90                  95      
Arg Phe Val Thr Gln Lys Arg Met Glu His Phe Tyr Leu Asn Phe Tyr
            100                 105                 110         
Thr Ala Glu Gln Leu Val Tyr Leu Ser Thr Glu Leu Arg Lys Gln Pro
        115                 120                 125             
Pro Ser Asp Ala Ala Leu Thr Met Leu Ser Phe Ile Lys Ser Asn Cys
    130                 135                 140                 
Thr Leu Arg Asp Val Leu Arg Ala Ser Val Gly Cys Gly Ser Glu Ala
145                 150                 155                 160 
Ala Arg Tyr Arg Met Arg Arg Val Met Glu Glu Leu Pro Leu Met Leu
                165                 170                 175     
Leu Ser Glu Phe Ser Leu Val Asp Lys Leu Arg Ile Ile Met Glu Gln
            180                 185                 190         
Ser Met Arg Cys Leu Pro Ala Phe Leu Pro Asp Cys Leu Asp Leu Glu
        195                 200                 205             
Thr Leu Gly His Cys Leu Ala His Leu Ala Gly Met Gly Gly Ser Pro
    210                 215                 220                 
Val Glu Arg Cys Leu Pro Arg Gly Leu Gln Val Gly Gln Pro Asn Leu
225                 230                 235                 240 
Val Val Cys Gly His Ser Glu Val Leu Pro Ala Ala Leu Ala Val Tyr
                245                 250                 255     
Met Gln Thr Pro Ser Gln Pro Leu Pro Thr Tyr Asp Glu Val Leu Leu
            260                 265                 270         
Cys Thr Pro Ala Thr Thr Phe Glu Glu Val Ala Leu Leu Leu Arg Arg
        275                 280                 285             
Cys Leu Thr Leu Gly Ser Leu Gly His Lys Val Tyr Ser Leu Leu Phe
    290                 295                 300                 
Ala Asp Gln Leu Ser Tyr Glu Val Ala Arg Gln Ala Glu Glu Leu Phe
305                 310                 315                 320 
His Asn Leu Cys Thr Gln Gln His Arg Glu Asp Tyr Gln Leu Val Met
                325                 330                 335     
Val Cys Asp Gly Asp Trp Glu His Cys Tyr Leu Pro Ser Ala Phe Ser
            340                 345                 350         
Gln His Lys Val Phe Val Thr Pro Gln Ala Pro Leu Glu Ala Ile Gln
        355                 360                 365             
Ala Tyr Leu Ala Gly His Tyr Arg Val Pro Lys Gln Thr Leu Ser Ala
    370                 375                 380                 
Ala Ala Val Phe Asn Asp Arg Leu Cys Val Gly Ile Val Ala Ser Glu
385                 390                 395                 400 
Arg Ala Gly Val Gly Lys Ser Leu Tyr Val Lys Arg Leu His Asp Lys
                405                 410                 415     
Met Lys Met Gln Leu Asn Val Lys Asn Val Pro Leu Lys Thr Ile Arg
            420                 425                 430         
Leu Ile Asp Pro Gln Val Asp Glu Ser Arg Val Leu Gly Ala Leu Leu
        435                 440                 445             
Pro Phe Leu Asp Ala Gln Tyr Gln Lys Val Pro Val Leu Phe His Leu
    450                 455                 460                 
Asp Val Thr Ser Ser Val Gln Thr Gly Ile Trp Val Phe Leu Phe Lys
465                 470                 475                 480 
Leu Leu Ile Leu Gln Tyr Leu Met Asp Ile Asn Gly Lys Met Trp Leu
                485                 490                 495     
Arg Asn Pro Cys His Leu Tyr Ile Val Glu Ile Leu Glu Arg Arg Thr
            500                 505                 510         
Ser Val Pro Ser Arg Ser Ser Ser Ala Leu Arg Thr Arg Val Pro Gln
        515                 520                 525             
Phe Ser Phe Leu Asp Ile Phe Pro Lys Val Thr Cys Arg Pro Pro Lys
    530                 535                 540                 
Glu Val Ile Asp Met Glu Leu Ser Ala Leu Arg Ser Asp Thr Glu Pro
545                 550                 555                 560 
Gly Met Asp Leu Trp Glu Phe Cys Ser Glu Thr Phe Gln Arg Pro Tyr
                565                 570                 575     
Gln Tyr Leu Arg Arg Phe Asn Gln Asn Gln Asp Leu Asp Thr Phe Gln
            580                 585                 590         
Tyr Gln Glu Gly Ser Val Glu Gly Thr Pro Glu Glu Cys Leu Gln His
        595                 600                 605             
Phe Leu Phe His Cys Gly Val Ile Asn Pro Ser Trp Ser Glu Leu Arg
    610                 615                 620                 
Asn Phe Ala Arg Phe Leu Asn Tyr Gln Leu Arg Asp Cys Glu Ala Ser
625                 630                 635                 640 
Leu Phe Cys Asn Pro Ser Phe Ile Gly Asp Thr Leu Arg Gly Phe Lys
                645                 650                 655     
Lys Phe Val Val Thr Phe Met Ile Phe Met Ala Arg Asp Phe Ala Thr
            660                 665                 670         
Pro Ser Leu His Thr Ser Asp Gln Ser Pro Gly Lys His Met Val Thr
        675                 680                 685             
Met Asp Gly Val Arg Glu Glu Asp Leu Ala Pro Phe Ser Leu Arg Lys
    690                 695                 700                 
Arg Trp Glu Ser Glu Pro His Pro Tyr Val Phe Phe Asn Asp Asp His
705                 710                 715                 720 
Thr Thr Met Thr Phe Ile Gly Phe His Leu Gln Pro Asn Ile Asn Gly
                725                 730                 735     
Ser Val Asp Ala Ile Ser His Leu Thr Gly Lys Val Ile Lys Arg Asp
            740                 745                 750         
Val Met Thr Arg Asp Leu Tyr Gln Gly Leu Leu Leu Gln Arg Val Pro
        755                 760                 765             
Phe Asn Val Asp Phe Asp Lys Leu Pro Arg His Lys Lys Leu Glu Arg
    770                 775                 780                 
Leu Cys Leu Thr Leu Gly Ile Pro Gln Ala Thr Asp Pro Asp Lys Thr
785                 790                 795                 800 
Tyr Glu Leu Thr Thr Asp Asn Met Leu Lys Ile Leu Ala Ile Glu Met
                805                 810                 815     
Arg Phe Arg Cys Gly Ile Pro Val Ile Ile Met Gly Glu Thr Gly Cys
            820                 825                 830         
Gly Lys Thr Arg Leu Ile Lys Phe Leu Ser Asp Leu Arg Arg Gly Gly
        835                 840                 845             
Thr Asn Ala Asp Thr Ile Lys Leu Val Lys Val His Gly Gly Thr Thr
    850                 855                 860                 
Ala Asp Met Ile Tyr Ser Arg Val Arg Glu Ala Glu Asn Val Ala Phe
865                 870                 875                 880 
Ala Asn Lys Asp Gln His Gln Leu Asp Thr Ile Leu Phe Phe Asp Glu
                885                 890                 895     
Ala Asn Thr Thr Glu Ala Ile Ser Cys Ile Lys Glu Val Leu Cys Asp
            900                 905                 910         
His Met Val Asp Gly Gln Pro Leu Ala Glu Asp Ser Gly Leu His Ile
        915                 920                 925             
Ile Ala Ala Cys Asn Pro Tyr Arg Lys His Ser Glu Glu Met Ile Cys
    930                 935                 940                 
Arg Leu Glu Ser Ala Gly Leu Gly Tyr Arg Val Ser Met Glu Glu Thr
945                 950                 955                 960 
Ala Asp Arg Leu Gly Ser Ile Pro Leu Arg Gln Leu Val Tyr Arg Val
                965                 970                 975     
His Ala Leu Pro Pro Ser Leu Ile Pro Leu Val Trp Asp Phe Gly Gln
            980                 985                 990         
Leu Ser Asp Val Ala Glu Lys Leu Tyr Ile Gln Gln Ile Val Gln Arg
        995                 1000                1005            
Leu Val Glu Ser Ile Ser Leu Asp Glu Asn Gly Thr Arg Val Ile Thr
    1010                1015                1020                
Glu Val Leu Cys Ala Ser Gln Gly Phe Met Arg Lys Thr Glu Asp Glu
1025                1030                1035                1040
Cys Ser Phe Val Ser Leu Arg Asp Val Glu Arg Cys Val Lys Val Phe
                1045                1050                1055    
Arg Trp Phe His Glu His Ser Ala Met Leu Leu Ala Gln Leu Asn Ala
            1060                1065                1070        
Phe Leu Ser Lys Ser Ser Val Ser Lys Asn His Thr Glu Arg Asp Pro
        1075                1080                1085            
Val Leu Trp Ser Leu Met Leu Ala Ile Gly Val Cys Tyr His Ala Ser
    1090                1095                1100                
Leu Glu Lys Lys Asp Ser Tyr Arg Lys Ala Ile Ala Arg Phe Phe Pro
1105                1110                1115                1120
Lys Pro Tyr Asp Asp Ser Arg Leu Leu Leu Asp Glu Ile Thr Arg Ala
                1125                1130                1135    
Gln Asp Leu Phe Leu Asp Gly Val Pro Leu Arg Lys Thr Ile Ala Lys
            1140                1145                1150        
Asn Leu Ala Leu Lys Glu Asn Val Phe Met Met Val Val Cys Ile Glu
        1155                1160                1165            
Leu Lys Ile Pro Leu Phe Leu Val Gly Lys Pro Gly Ser Ser Lys Ser
    1170                1175                1180                
Leu Ala Lys Thr Ile Val Ala Asp Ala Met Gln Gly Pro Ala Ala Tyr
1185                1190                1195                1200
Ser Asp Leu Phe Arg Ser Leu Lys Gln Val His Leu Val Ser Phe Gln
                1205                1210                1215    
Cys Ser Pro His Ser Thr Pro Gln Gly Ile Ile Ser Thr Phe Arg Gln
            1220                1225                1230        
Cys Ala Arg Phe Gln Gln Gly Lys Asp Leu Gln Gln Tyr Val Ser Val
        1235                1240                1245            
Val Val Leu Asp Glu Val Gly Leu Ala Glu Asp Ser Pro Lys Met Pro
    1250                1255                1260                
Leu Lys Thr Leu His Pro Leu Leu Glu Asp Gly Cys Ile Glu Asp Asp
1265                1270                1275                1280
Pro Ala Pro His Lys Lys Val Gly Phe Val Gly Ile Ser Asn Trp Ala
                1285                1290                1295    
Leu Asp Pro Ala Lys Met Asn Arg Gly Ile Phe Val Ser Arg Gly Ser
            1300                1305                1310        
Pro Asn Glu Thr Glu Leu Ile Glu Ser Ala Lys Gly Ile Cys Ser Ser
        1315                1320                1325            
Asp Ile Leu Val Gln Asp Arg Val Gln Gly Tyr Phe Ala Ser Phe Ala
    1330                1335                1340                
Lys Ala Tyr Glu Thr Val Cys Lys Arg Gln Asp Lys Glu Phe Phe Gly
1345                1350                1355                1360
Leu Arg Asp Tyr Tyr Ser Leu Ile Lys Met Val Phe Ala Ala Ala Lys
                1365                1370                1375    
Ala Ser Asn Arg Lys Pro Ser Pro Gln Asp Ile Ala Gln Ala Val Leu
            1380                1385                1390        
Arg Asn Phe Ser Gly Lys Asp Asp Ile Gln Ala Leu Asp Ile Phe Leu
        1395                1400                1405            
Ala Asn Leu Pro Glu Ala Lys Cys Ser Glu Glu Val Ser Pro Met Gln
    1410                1415                1420                
Leu Ile Lys Gln Asn Ile Phe Gly Pro Ser Gln Lys Val Pro Gly Gly
1425                1430                1435                1440
Glu Gln Glu Asp Ala Glu Ser Arg Tyr Leu Leu Val Leu Thr Lys Asn
                1445                1450                1455    
Tyr Val Ala Leu Gln Ile Leu Gln Gln Thr Phe Phe Glu Gly Asp Gln
            1460                1465                1470        
Gln Pro Glu Ile Ile Phe Gly Ser Gly Phe Pro Lys Asp Gln Glu Tyr
        1475                1480                1485            
Thr Gln Leu Cys Arg Asn Ile Asn Arg Val Lys Ile Cys Met Glu Thr
    1490                1495                1500                
Gly Lys Met Val Leu Leu Leu Asn Leu Gln Asn Leu Tyr Glu Ser Leu
1505                1510                1515                1520
Tyr Asp Ala Leu Asn Gln Tyr Tyr Val His Leu Gly Gly Gln Lys Tyr
                1525                1530                1535    
Val Asp Leu Gly Leu Gly Thr His Arg Val Lys Cys Arg Val His Pro
            1540                1545                1550        
Asn Phe Arg Leu Ile Val Ile Glu Glu Lys Asp Val Val Tyr Lys His
        1555                1560                1565            
Phe Pro Ile Pro Leu Ile Asn Arg Leu Glu Lys His Tyr Leu Asp Ile
    1570                1575                1580                
Asn Thr Val Leu Glu Lys Trp Gln Lys Ser Ile Val Glu Glu Leu Cys
1585                1590                1595                1600
Ala Trp Val Glu Lys Phe Ile Asn Val Lys Ala His His Phe Gln Lys
                1605                1610                1615    
Arg His Lys Tyr Ser Pro Ser Asp Val Phe Ile Gly Tyr His Ser Asp
            1620                1625                1630        
Ala Cys Ala Ser Val Val Leu Gln Val Ile Glu Arg Gln Gly Pro Arg
        1635                1640                1645            
Ala Leu Thr Glu Glu Leu His Gln Lys Val Ser Glu Glu Ala Lys Ser
    1650                1655                1660                
Ile Leu Leu Asn Cys Ala Thr Pro Asp Ala Val Val Arg Leu Ser Ala
1665                1670                1675                1680
Tyr Ser Leu Gly Gly Phe Ala Ala Glu Trp Leu Ser Gln Glu Tyr Phe
                1685                1690                1695    
His Arg Gln Arg His Asn Ser Phe Ala Asp Phe Leu Gln Ala His Leu
            1700                1705                1710        
His Thr Ala Asp Leu Glu Arg His Ala Ile Phe Thr Glu Ile Thr Thr
        1715                1720                1725            
Phe Ser Arg Leu Leu Thr Ser His Asp Cys Glu Ile Leu Glu Ser Glu
    1730                1735                1740                
Val Thr Gly Arg Ala Pro Lys Pro Thr Leu Leu Trp Leu Gln Gln Phe
1745                1750                1755                1760
Asp Thr Glu Tyr Ser Phe Leu Lys Glu Val Arg Asn Cys Leu Thr Asn
                1765                1770                1775    
Thr Ala Lys Cys Lys Ile Leu Ile Phe Gln Thr Asp Phe Glu Asp Gly
            1780                1785                1790        
Ile Arg Ser Ala Gln Leu Ile Ala Ser Ala Lys Tyr Val Phe Ser Ile
        1795                1800                1805            
Phe Leu Arg Asn Tyr Val Lys Asn Pro Lys Leu Arg Gly Leu Asn Leu
    1810                1815                1820                
Asn Lys Lys Leu Ala Leu Ala Ile Gly His Leu Lys Gly Met Ala Leu
1825                1830                1835                1840
Arg Thr Glu Leu Phe Val Glu Met Glu Arg Tyr Ser Val Ile Asn Glu
                1845                1850                1855    
Ile Asn Lys Ile Arg Glu Asn Glu Asp Arg Ile Phe Val Tyr Phe Ile
            1860                1865                1870        
Thr Lys Leu Ser Arg Val Gly Arg Gly Thr Ala Tyr Val Gly Phe His
        1875                1880                1885            
Gly Gly Leu Trp Gln Ser Val His Ile Asp Asp Leu Arg Arg Ser Thr
    1890                1895                1900                
Leu Met Val Ser Asp Val Thr Arg Leu Gln His Val Thr Ile Ser Gln
1905                1910                1915                1920
Leu Phe Ala Pro Gly Asp Leu Pro Glu Arg Ala Arg Gly His Ile Cys
                1925                1930                1935    
Arg Thr Asp Trp Trp Leu Ile Ile Glu His Gln Gly Arg Ala Val Gly
            1940                1945                1950        
Leu Glu His Arg Ala Glu Asp Gly His Glu Glu Ala Met Glu Thr Glu
        1955                1960                1965            
Ala Ser Thr Ser Gly Glu Val Ala Glu Val Ala Glu Glu Ala Met Glu
    1970                1975                1980                
Thr Glu Ser Ser Glu Lys Val Gly Lys Glu Thr Ser Glu Leu Gly Gly
1985                1990                1995                2000
Ser Asp Val Ser Ile Leu Asp Thr Thr Arg Leu Leu Arg Ser Cys Val
                2005                2010                2015    
Gln Ser Ala Val Gly Met Leu Arg Asp Gln Asn Glu Ser Cys Thr Arg
            2020                2025                2030        
Asn Met Arg Arg Val Val Leu Leu Leu Gly Leu Leu Asn Glu Asp Asp
        2035                2040                2045            
Ala Cys His Ala Ser Phe Leu Arg Val Ser Lys Met Arg Leu Ser Val
    2050                2055                2060                
Phe Leu Lys Lys Gln Glu Glu Ser Gln Phe His Pro Leu Glu Trp Leu
2065                2070                2075                2080
Ala Arg Glu Ala Cys Asn Gln Asp Ala Leu Gln Glu Ala Gly Thr Phe
                2085                2090                2095    
Arg His Thr Leu Trp Lys Arg Val Gln Gly Ala Val Thr Pro Leu Leu
            2100                2105                2110        
Ala Ser Met Ile Ser Phe Ile Asp Arg Asp Gly Asn Leu Glu Leu Leu
        2115                2120                2125            
Thr Arg Pro Asp Thr Pro Pro Trp Ala Arg Asp Leu Trp Met Phe Ile
    2130                2135                2140                
Phe Ser Asp Thr Met Leu Leu Asn Ile Pro Leu Val Met Asn Asn Glu
2145                2150                2155                2160
Arg His Lys Gly Glu Met Ala Tyr Ile Val Val Gln Asn His Met Asn
                2165                2170                2175    
Leu Ser Glu Asn Ala Ser Asn Asn Val Pro Phe Ser Trp Lys Ile Lys
            2180                2185                2190        
Asp Tyr Leu Glu Glu Leu Trp Val Gln Ala Gln Tyr Ile Thr Asp Ala
        2195                2200                2205            
Glu Gly Leu Pro Lys Lys Phe Val Asp Ile Phe Gln Gln Thr Pro Leu
    2210                2215                2220                
Gly Arg Phe Leu Ala Gln Leu His Gly Glu Pro Gln Gln Glu Leu Leu
2225                2230                2235                2240
Gln Cys Tyr Leu Lys Asp Phe Ile Leu Leu Thr Met Arg Val Ser Thr
                2245                2250                2255    
Glu Glu Glu Leu Lys Phe Leu Gln Met Ala Leu Trp Ser Cys Thr Arg
            2260                2265                2270        
Lys Leu Lys Ala Ala Ser Glu Ala Pro Glu Glu Glu Val Ser Leu Pro
        2275                2280                2285            
Trp Val His Leu Ala Tyr Gln Arg Phe Arg Ser Arg Leu Gln Asn Phe
    2290                2295                2300                
Ser Arg Ile Leu Thr Ile Tyr Pro Gln Val Leu His Ser Leu Met Glu
2305                2310                2315                2320
Ala Arg Trp Asn His Glu Leu Ala Gly Cys Glu Met Thr Leu Asp Ala
                2325                2330                2335    
Phe Ala Ala Met Ala Cys Thr Glu Met Leu Thr Arg Asn Thr Leu Lys
            2340                2345                2350        
Pro Ser Pro Gln Ala Trp Leu Gln Leu Val Lys Asn Leu Ser Met Pro
        2355                2360                2365            
Leu Glu Leu Ile Cys Ser Asp Glu His Met Gln Gly Ser Gly Ser Leu
    2370                2375                2380                
Ala Gln Ala Val Ile Arg Glu Val Arg Ala Gln Trp Ser Arg Ile Phe
2385                2390                2395                2400
Ser Thr Ala Leu Phe Val Glu His Val Leu Leu Gly Thr Glu Ser Arg
                2405                2410                2415    
Val Pro Glu Leu Gln Gly Leu Val Thr Glu His Val Phe Leu Leu Asp
            2420                2425                2430        
Lys Cys Leu Arg Glu Asn Ser Asp Val Lys Thr His Gly Pro Phe Glu
        2435                2440                2445            
Ala Val Met Arg Thr Leu Cys Glu Cys Lys Glu Thr Ala Ser Lys Thr
    2450                2455                2460                
Leu Ser Arg Phe Gly Ile Gln Pro Cys Ser Ile Cys Leu Gly Asp Ala
2465                2470                2475                2480
Lys Asp Pro Val Cys Leu Pro Cys Asp His Val His Cys Leu Arg Cys
                2485                2490                2495    
Leu Arg Ala Trp Phe Ala Ser Glu Gln Met Ile Cys Pro Tyr Cys Leu
            2500                2505                2510        
Thr Ala Leu Pro Asp Glu Phe Ser Pro Ala Val Ser Gln Ala His Arg
        2515                2520                2525            
Glu Ala Ile Glu Lys His Ala Arg Phe Arg Gln Met Cys Asn Ser Phe
    2530                2535                2540                
Phe Val Asp Leu Val Ser Thr Ile Cys Phe Lys Asp Asn Ala Pro Pro
2545                2550                2555                2560
Glu Lys Glu Val Ile Glu Ser Leu Leu Ser Leu Leu Phe Val Gln Lys
                2565                2570                2575    
Gly Arg Leu Arg Asp Ala Ala Gln Arg His Cys Glu His Thr Lys Ser
            2580                2585                2590        
Leu Ser Pro Phe Asn Asp Val Val Asp Lys Thr Pro Val Ile Arg Ser
        2595                2600                2605            
Val Ile Leu Lys Leu Leu Leu Lys Tyr Ser Phe His Asp Val Lys Asp
    2610                2615                2620                
Tyr Ile Gln Glu Tyr Leu Thr Leu Leu Lys Lys Lys Ala Phe Ile Thr
2625                2630                2635                2640
Glu Asp Lys Thr Glu Leu Tyr Met Leu Phe Ile Asn Cys Leu Glu Asp
                2645                2650                2655    
Ser Ile Leu Glu Lys Thr Ser Ala Tyr Ser Arg Asn Asp Glu Leu Asn
            2660                2665                2670        
His Leu Glu Glu Glu Gly Arg Phe Leu Lys Ala Tyr Ser Pro Ala Ser
        2675                2680                2685            
Arg Gly Arg Glu Pro Ala Asn Glu Ala Ser Val Glu Tyr Leu Gln Glu
    2690                2695                2700                
Val Ala Arg Ile Arg Leu Cys Leu Asp Arg Ala Ala Asp Phe Leu Ser
2705                2710                2715                2720
Glu Pro Glu Gly Gly Pro Glu Met Ala Lys Glu Lys Gln Cys Tyr Leu
                2725                2730                2735    
Gln Gln Val Lys Gln Phe Cys Ile Arg Val Glu Asn Asp Trp His Arg
            2740                2745                2750        
Val Tyr Leu Val Arg Lys Leu Ser Ser Gln Arg Gly Met Glu Phe Val
        2755                2760                2765            
Gln Gly Leu Ser Lys Pro Gly Arg Pro His Gln Trp Val Phe Pro Lys
    2770                2775                2780                
Asp Val Val Lys Gln Gln Gly Leu Arg Gln Asp His Pro Gly Gln Met
2785                2790                2795                2800
Asp Arg Tyr Leu Val Tyr Gly Asp Glu Tyr Lys Ala Leu Arg Asp Ala
                2805                2810                2815    
Val Ala Lys Ala Val Leu Glu Cys Lys Pro Leu Gly Ile Lys Thr Ala
            2820                2825                2830        
Leu Lys Ala Cys Lys Thr Pro Gln Ser Gln Gln Ser Ala Tyr Phe Leu
        2835                2840                2845            
Leu Thr Leu Phe Arg Glu Val Ala Ile Leu Tyr Arg Ser His Asn Ala
    2850                2855                2860                
Ser Leu His Pro Thr Pro Glu Gln Cys Glu Ala Val Ser Lys Phe Ile
2865                2870                2875                2880
Gly Glu Cys Lys Ile Leu Ser Pro Pro Asp Ile Ser Arg Phe Ala Thr
                2885                2890                2895    
Ser Leu Val Asp Asn Ser Val Pro Leu Leu Arg Ala Gly Pro Ser Asp
            2900                2905                2910        
Ser Asn Leu Asp Gly Thr Val Thr Glu Met Ala Ile His Ala Ala Ala
        2915                2920                2925            
Val Leu Leu Cys Gly Gln Asn Glu Leu Leu Glu Pro Leu Lys Asn Leu
    2930                2935                2940                
Ala Phe Ser Pro Ala Thr Met Ala His Ala Phe Leu Pro Thr Met Pro
2945                2950                2955                2960
Glu Asp Leu Leu Ala Gln Ala Arg Arg Trp Lys Gly Leu Glu Arg Val
                2965                2970                2975    
His Trp Tyr Thr Cys Pro Asn Gly His Pro Cys Ser Val Gly Glu Cys
            2980                2985                2990        
Gly Arg Pro Met Glu Gln Ser Ile Cys Ile Asp Cys His Ala Pro Ile
        2995                3000                3005            
Gly Gly Ile Asp His Lys Pro Arg Asp Gly Phe His Leu Val Lys Asp
    3010                3015                3020                
Lys Ala Asp Arg Thr Gln Thr Gly His Val Leu Gly Asn Pro Gln Arg
3025                3030                3035                3040
Arg Asp Val Val Thr Cys Asp Arg Gly Leu Pro Pro Val Val Phe Leu
                3045                3050                3055    
Leu Ile Arg Leu Leu Thr His Leu Ala Leu Leu Leu Gly Ala Ser Gln
            3060                3065                3070        
Ser Ser Gln Ala Leu Ile Asn Ile Ile Lys Pro Pro Val Arg Asp Pro
        3075                3080                3085            
Lys Gly Phe Leu Gln Gln His Ile Leu Lys Asp Leu Glu Gln Leu Ala
    3090                3095                3100                
Lys Met Leu Gly His Ser Ala Asp Glu Thr Ile Gly Val Val His Leu
3105                3110                3115                3120
Val Leu Arg Arg Leu Leu Gln Glu Gln His Gln Leu Ser Ser Arg Arg
                3125                3130                3135    
Leu Leu Asn Phe Asp Thr Glu Leu Ser Thr Lys Glu Met Arg Asn Asn
            3140                3145                3150        
Trp Glu Lys Glu Ile Ala Ala Val Ile Ser Pro Glu Leu Glu His Leu
        3155                3160                3165            
Asp Lys Thr Leu Pro Thr Met Asn Asn Leu Ile Ser Gln Asp Lys Arg
    3170                3175                3180                
Ile Ser Ser Asn Pro Val Ala Lys Ile Ile Tyr Gly Asp Pro Val Thr
3185                3190                3195                3200
Phe Leu Pro His Leu Pro Arg Lys Ser Val Val His Cys Ser Lys Ile
                3205                3210                3215    
Trp Ser Cys Arg Lys Arg Ile Thr Val Glu Tyr Leu Gln His Ile Val
            3220                3225                3230        
Glu Gln Lys Asn Gly Lys Glu Arg Val Pro Ile Leu Trp His Phe Leu
        3235                3240                3245            
Gln Lys Glu Ala Glu Leu Arg Leu Val Lys Phe Leu Pro Glu Ile Leu
    3250                3255                3260                
Ala Leu Gln Arg Asp Leu Val Lys Gln Phe Gln Asn Val Gln Gln Val
3265                3270                3275                3280
Glu Tyr Ser Ser Ile Arg Gly Phe Leu Ser Lys His Ser Ser Asp Gly
                3285                3290                3295    
Leu Arg Gln Leu Leu His Asn Arg Ile Thr Val Phe Leu Ser Thr Trp
            3300                3305                3310        
Asn Lys Leu Arg Arg Ser Leu Glu Thr Asn Gly Glu Ile Asn Leu Pro
        3315                3320                3325            
Lys Asp Tyr Cys Ser Thr Asp Leu Asp Leu Asp Thr Glu Phe Glu Ile
    3330                3335                3340                
Leu Leu Pro Arg Arg Arg Gly Leu Gly Leu Cys Ala Thr Ala Leu Val
3345                3350                3355                3360
Ser Tyr Leu Ile Arg Leu His Asn Glu Ile Val Tyr Ala Val Glu Lys
                3365                3370                3375    
Leu Ser Lys Glu Asn Asn Ser Tyr Ser Val Asp Ala Ala Glu Val Thr
            3380                3385                3390        
Glu Leu His Val Ile Ser Tyr Glu Val Glu Arg Asp Leu Thr Pro Leu
        3395                3400                3405            
Ile Leu Ser Asn Cys Gln Tyr Gln Val Glu Glu Gly Arg Glu Thr Val
    3410                3415                3420                
Gln Glu Phe Asp Leu Glu Lys Ile Gln Arg Gln Ile Val Ser Arg Phe
3425                3430                3435                3440
Leu Gln Gly Lys Pro Arg Leu Ser Leu Lys Gly Ile Pro Thr Leu Val
                3445                3450                3455    
Tyr Arg His Asp Trp Asn Tyr Glu His Leu Phe Met Asp Ile Lys Asn
            3460                3465                3470        
Lys Met Ala Gln Asp Ser Leu Pro Ser Ser Val Ile Ser Ala Ile Ser
        3475                3480                3485            
Gly Gln Leu Gln Ser Tyr Ser Asp Ala Cys Glu Val Leu Ser Val Val
    3490                3495                3500                
Glu Val Thr Leu Gly Phe Leu Ser Thr Ala Gly Gly Asp Pro Asn Met
3505                3510                3515                3520
Gln Leu Asn Val Tyr Thr Gln Asp Ile Leu Gln Met Gly Asp Gln Thr
                3525                3530                3535    
Ile His Val Leu Lys Ala Leu Asn Arg Cys Gln Leu Lys His Thr Ile
            3540                3545                3550        
Ala Leu Trp Gln Phe Leu Ser Ala His Lys Ser Glu Gln Leu Leu Arg
        3555                3560                3565            
Leu His Lys Glu Pro Phe Gly Glu Ile Ser Ser Arg Tyr Lys Ala Asp
    3570                3575                3580                
Leu Ser Pro Glu Asn Ala Lys Leu Leu Ser Thr Phe Leu Asn Gln Thr
3585                3590                3595                3600
Gly Leu Asp Ala Phe Leu Leu Glu Leu His Glu Met Ile Ile Leu Lys
                3605                3610                3615    
Leu Lys Asn Pro Gln Thr Gln Thr Glu Glu Arg Phe Arg Pro Gln Trp
            3620                3625                3630        
Ser Leu Arg Asp Thr Leu Val Ser Tyr Met Gln Thr Lys Glu Ser Glu
        3635                3640                3645            
Ile Leu Pro Glu Met Ala Ser Gln Phe Pro Glu Glu Ile Leu Leu Ala
    3650                3655                3660                
Ser Cys Val Ser Val Trp Lys Thr Ala Ala Val Leu Lys Trp Asn Arg
3665                3670                3675                3680
Glu Met Arg
            


<210> 7247
<211> 1320
<212> PRT
<213> Homo sapiens

<400> 7247
Asn Leu Ser Met Pro Leu Glu Leu Ile Cys Ser Asp Glu His Met Gln
 1               5                  10                  15      
Gly Ser Gly Ser Leu Ala Gln Ala Val Ile Arg Glu Val Arg Ala Gln
            20                  25                  30          
Trp Ser Arg Ile Phe Ser Thr Ala Leu Phe Val Glu His Val Leu Leu
        35                  40                  45              
Gly Thr Glu Ser Arg Val Pro Glu Leu Gln Gly Leu Val Thr Glu His
    50                  55                  60                  
Val Phe Leu Leu Asp Lys Cys Leu Arg Glu Asn Ser Asp Val Lys Thr
65                  70                  75                  80  
His Gly Pro Phe Glu Ala Val Met Arg Thr Leu Cys Glu Cys Lys Glu
                85                  90                  95      
Thr Ala Ser Lys Thr Leu Ser Arg Phe Gly Ile Gln Pro Cys Ser Ile
            100                 105                 110         
Cys Leu Gly Asp Ala Lys Asp Pro Val Cys Leu Pro Cys Asp His Val
        115                 120                 125             
His Cys Leu Arg Cys Leu Arg Ala Trp Phe Ala Ser Glu Gln Met Ile
    130                 135                 140                 
Cys Pro Tyr Cys Leu Thr Ala Leu Pro Asp Glu Phe Ser Pro Ala Val
145                 150                 155                 160 
Ser Gln Ala His Arg Glu Ala Ile Glu Lys His Ala Arg Phe Arg Gln
                165                 170                 175     
Met Cys Asn Ser Phe Phe Val Asp Leu Val Ser Thr Ile Cys Phe Lys
            180                 185                 190         
Asp Asn Ala Pro Pro Glu Lys Glu Val Ile Glu Ser Leu Leu Ser Leu
        195                 200                 205             
Leu Phe Val Gln Lys Gly Arg Leu Arg Asp Ala Ala Gln Arg His Cys
    210                 215                 220                 
Glu His Thr Lys Ser Leu Ser Pro Phe Asn Asp Val Val Asp Lys Thr
225                 230                 235                 240 
Pro Val Ile Arg Ser Val Ile Leu Lys Leu Leu Leu Lys Tyr Ser Phe
                245                 250                 255     
His Asp Val Lys Asp Tyr Ile Gln Glu Tyr Leu Thr Leu Leu Lys Lys
            260                 265                 270         
Lys Ala Phe Ile Thr Glu Asp Lys Thr Glu Leu Tyr Met Leu Phe Ile
        275                 280                 285             
Asn Cys Leu Glu Asp Ser Ile Leu Glu Lys Thr Ser Ala Tyr Ser Arg
    290                 295                 300                 
Asn Asp Glu Leu Asn His Leu Glu Glu Glu Gly Arg Phe Leu Lys Ala
305                 310                 315                 320 
Tyr Ser Pro Ala Ser Arg Gly Arg Glu Pro Ala Asn Glu Ala Ser Val
                325                 330                 335     
Glu Tyr Leu Gln Glu Val Ala Arg Ile Arg Leu Cys Leu Asp Arg Ala
            340                 345                 350         
Ala Asp Phe Leu Ser Glu Pro Glu Gly Gly Pro Glu Met Ala Lys Glu
        355                 360                 365             
Lys Gln Cys Tyr Leu Gln Gln Val Lys Gln Phe Cys Ile Arg Val Glu
    370                 375                 380                 
Asn Asp Trp His Arg Val Tyr Leu Val Arg Lys Leu Ser Ser Gln Arg
385                 390                 395                 400 
Gly Met Glu Phe Val Gln Gly Leu Ser Lys Pro Gly Arg Pro His Gln
                405                 410                 415     
Trp Val Phe Pro Lys Asp Val Val Lys Gln Gln Gly Leu Arg Gln Asp
            420                 425                 430         
His Pro Gly Gln Met Asp Arg Tyr Leu Val Tyr Gly Asp Glu Tyr Lys
        435                 440                 445             
Ala Leu Arg Asp Ala Val Ala Lys Ala Val Leu Glu Cys Lys Pro Leu
    450                 455                 460                 
Gly Ile Lys Thr Ala Leu Lys Ala Cys Lys Thr Pro Gln Ser Gln Gln
465                 470                 475                 480 
Ser Ala Tyr Phe Leu Leu Thr Leu Phe Arg Glu Val Ala Ile Leu Tyr
                485                 490                 495     
Arg Ser His Asn Ala Ser Leu His Pro Thr Pro Glu Gln Cys Glu Ala
            500                 505                 510         
Val Ser Lys Phe Ile Gly Glu Cys Lys Ile Leu Ser Pro Pro Asp Ile
        515                 520                 525             
Ser Arg Phe Ala Thr Ser Leu Val Asp Asn Ser Val Pro Leu Leu Arg
    530                 535                 540                 
Ala Gly Pro Ser Asp Ser Asn Leu Asp Gly Thr Val Thr Glu Met Ala
545                 550                 555                 560 
Ile His Ala Ala Ala Val Leu Leu Cys Gly Gln Asn Glu Leu Leu Glu
                565                 570                 575     
Pro Leu Lys Asn Leu Ala Phe Ser Pro Ala Thr Met Ala His Ala Phe
            580                 585                 590         
Leu Pro Thr Met Pro Glu Asp Leu Leu Ala Gln Ala Arg Arg Trp Lys
        595                 600                 605             
Gly Leu Glu Arg Val His Trp Tyr Thr Cys Pro Asn Gly His Pro Cys
    610                 615                 620                 
Ser Val Gly Glu Cys Gly Arg Pro Met Glu Gln Ser Ile Cys Ile Asp
625                 630                 635                 640 
Cys His Ala Pro Ile Gly Gly Ile Asp His Lys Pro Arg Asp Gly Phe
                645                 650                 655     
His Leu Val Lys Asp Lys Ala Asp Arg Thr Gln Thr Gly His Val Leu
            660                 665                 670         
Gly Asn Pro Gln Arg Arg Asp Val Val Thr Cys Asp Arg Gly Leu Pro
        675                 680                 685             
Pro Val Val Phe Leu Leu Ile Arg Leu Leu Thr His Leu Ala Leu Leu
    690                 695                 700                 
Leu Gly Ala Ser Gln Ser Ser Gln Ala Leu Ile Asn Ile Ile Lys Pro
705                 710                 715                 720 
Pro Val Arg Asp Pro Lys Gly Phe Leu Gln Gln His Ile Leu Lys Asp
                725                 730                 735     
Leu Glu Gln Leu Ala Lys Met Leu Gly His Ser Ala Asp Glu Thr Ile
            740                 745                 750         
Gly Val Val His Leu Val Leu Arg Arg Leu Leu Gln Glu Gln His Gln
        755                 760                 765             
Leu Ser Ser Arg Arg Leu Leu Asn Phe Asp Thr Glu Leu Ser Thr Lys
    770                 775                 780                 
Glu Met Arg Asn Asn Trp Glu Lys Glu Ile Ala Ala Val Ile Ser Pro
785                 790                 795                 800 
Glu Leu Glu His Leu Asp Lys Thr Leu Pro Thr Met Asn Asn Leu Ile
                805                 810                 815     
Ser Gln Asp Lys Arg Ile Ser Ser Asn Pro Val Ala Lys Ile Ile Tyr
            820                 825                 830         
Gly Asp Pro Val Thr Phe Leu Pro His Leu Pro Arg Lys Ser Val Val
        835                 840                 845             
His Cys Ser Lys Ile Trp Ser Cys Arg Lys Arg Ile Thr Val Glu Tyr
    850                 855                 860                 
Leu Gln His Ile Val Glu Gln Lys Asn Gly Lys Glu Arg Val Pro Ile
865                 870                 875                 880 
Leu Trp His Phe Leu Gln Lys Glu Ala Glu Leu Arg Leu Val Lys Phe
                885                 890                 895     
Leu Pro Glu Ile Leu Ala Leu Gln Arg Asp Leu Val Lys Gln Phe Gln
            900                 905                 910         
Asn Val Gln Gln Val Glu Tyr Ser Ser Ile Arg Gly Phe Leu Ser Lys
        915                 920                 925             
His Ser Ser Asp Gly Leu Arg Gln Leu Leu His Asn Arg Ile Thr Val
    930                 935                 940                 
Phe Leu Ser Thr Trp Asn Lys Leu Arg Arg Ser Leu Glu Thr Asn Gly
945                 950                 955                 960 
Glu Ile Asn Leu Pro Lys Asp Tyr Cys Ser Thr Asp Leu Asp Leu Asp
                965                 970                 975     
Thr Glu Phe Glu Ile Leu Leu Pro Arg Arg Arg Gly Leu Gly Leu Cys
            980                 985                 990         
Ala Thr Ala Leu Val Ser Tyr Leu Ile Arg Leu His Asn Glu Ile Val
        995                 1000                1005            
Tyr Ala Val Glu Lys Leu Ser Lys Glu Asn Asn Ser Tyr Ser Val Asp
    1010                1015                1020                
Ala Ala Glu Val Thr Glu Leu His Val Ile Ser Tyr Glu Val Glu Arg
1025                1030                1035                1040
Asp Leu Thr Pro Leu Ile Leu Ser Asn Cys Gln Tyr Gln Val Glu Glu
                1045                1050                1055    
Gly Arg Glu Thr Val Gln Glu Phe Asp Leu Glu Lys Ile Gln Arg Gln
            1060                1065                1070        
Ile Val Ser Arg Phe Leu Gln Gly Lys Pro Arg Leu Ser Leu Lys Gly
        1075                1080                1085            
Ile Pro Thr Leu Val Tyr Arg His Asp Trp Asn Tyr Glu His Leu Phe
    1090                1095                1100                
Met Asp Ile Lys Asn Lys Met Ala Gln Asp Ser Leu Pro Ser Ser Val
1105                1110                1115                1120
Ile Ser Ala Ile Ser Gly Gln Leu Gln Ser Tyr Ser Asp Ala Cys Glu
                1125                1130                1135    
Val Leu Ser Val Val Glu Val Thr Leu Gly Phe Leu Ser Thr Ala Gly
            1140                1145                1150        
Gly Asp Pro Asn Met Gln Leu Asn Val Tyr Thr Gln Asp Ile Leu Gln
        1155                1160                1165            
Met Gly Asp Gln Thr Ile His Val Leu Lys Ala Leu Asn Arg Cys Gln
    1170                1175                1180                
Leu Lys His Thr Ile Ala Leu Trp Gln Phe Leu Ser Ala His Lys Ser
1185                1190                1195                1200
Glu Gln Leu Leu Arg Leu His Lys Glu Pro Phe Gly Glu Ile Ser Ser
                1205                1210                1215    
Arg Tyr Lys Ala Asp Leu Ser Pro Glu Asn Ala Lys Leu Leu Ser Thr
            1220                1225                1230        
Phe Leu Asn Gln Thr Gly Leu Asp Ala Phe Leu Leu Glu Leu His Glu
        1235                1240                1245            
Met Ile Ile Leu Lys Leu Lys Asn Pro Gln Thr Gln Thr Glu Glu Arg
    1250                1255                1260                
Phe Arg Pro Gln Trp Ser Leu Arg Asp Thr Leu Val Ser Tyr Met Gln
1265                1270                1275                1280
Thr Lys Glu Ser Glu Ile Leu Pro Glu Met Ala Ser Gln Phe Pro Glu
                1285                1290                1295    
Glu Ile Leu Leu Ala Ser Cys Val Ser Val Trp Lys Thr Ala Ala Val
            1300                1305                1310        
Leu Lys Trp Asn Arg Glu Met Arg
        1315                1320


<210> 7248
<211> 474
<212> PRT
<213> Homo sapiens

<400> 7248
Met Thr Thr Phe Lys Glu Ala Val Thr Phe Lys Asp Val Ala Val Phe
 1               5                  10                  15      
Phe Thr Glu Glu Glu Leu Gly Leu Leu His Pro Ala Gln Arg Lys Leu
            20                  25                  30          
Tyr Gln Asp Val Met Leu Glu Asn Phe Thr Asn Leu Leu Ser Val Gly
        35                  40                  45              
His Gln Pro Phe His Pro Phe His Phe Leu Arg Glu Glu Lys Phe Trp
    50                  55                  60                  
Met Met Glu Thr Ala Thr Gln Arg Glu Gly Asn Ser Gly Gly Lys Thr
65                  70                  75                  80  
Ile Ala Glu Ala Gly Pro His Glu Asp Cys Pro Val Gln Gln Ile Trp
                85                  90                  95      
Glu Gln Thr Ala Ser Asp Leu Thr Gln Ser Gln Asp Ser Ile Ile Asn
            100                 105                 110         
Asn Ser His Phe Phe Glu Gln Gly Asp Val Pro Ser Gln Val Glu Ala
        115                 120                 125             
Gly Leu Ser Ile Ile His Thr Gly Gln Lys Pro Ser Gln Asn Gly Lys
    130                 135                 140                 
Cys Lys Gln Ser Phe Ser Asp Val Ala Ile Phe Asp Pro Pro Gln Gln
145                 150                 155                 160 
Phe His Ser Gly Glu Lys Ser His Thr Cys Asn Glu Cys Gly Lys Ser
                165                 170                 175     
Phe Cys Tyr Ile Ser Ala Leu Arg Ile His Gln Arg Val His Leu Arg
            180                 185                 190         
Glu Lys Leu Ser Lys Cys Asp Met Cys Gly Lys Glu Phe Ser Gln Ser
        195                 200                 205             
Ser Cys Leu Gln Thr His Glu Arg Val His Thr Arg Glu Lys Pro Phe
    210                 215                 220                 
Lys Cys Glu Gln Cys Gly Lys Gly Phe Arg Cys Arg Ala Ile Leu Gln
225                 230                 235                 240 
Val His Cys Lys Leu His Thr Gly Glu Lys Pro Tyr Ile Cys Glu Lys
                245                 250                 255     
Cys Gly Arg Ala Phe Ile His Asp Leu Lys Leu Gln Lys His Gln Ile
            260                 265                 270         
Ile His Thr Gly Glu Lys Pro Ser Lys Cys Glu Ile Cys Gly Lys Ser
        275                 280                 285             
Phe Cys Leu Arg Ser Ser Leu Asn Arg His Tyr Met Val His Thr Ala
    290                 295                 300                 
Glu Lys Leu Ser Lys Cys Glu Glu Cys Gly Lys Gly Phe Thr Asp Ser
305                 310                 315                 320 
Leu Asp Leu His Lys His Gln Ile Ile His Thr Gly Gln Lys Pro Tyr
                325                 330                 335     
Asn Cys Lys Glu Cys Gly Lys Ser Phe Arg Trp Ser Ser Tyr Leu Leu
            340                 345                 350         
Ile His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Arg Cys Glu Glu
        355                 360                 365             
Cys Gly Lys Gly Tyr Ile Ser Lys Ser Gly Leu Asn Leu His Pro Glu
    370                 375                 380                 
Gly His Thr Gly Glu Arg Pro Tyr Asn Cys Lys Glu Cys Gly Lys Ser
385                 390                 395                 400 
Phe Ser Arg Ala Ser Ser Ile Leu Asn His Lys Lys Leu His Cys Arg
                405                 410                 415     
Lys Lys Pro Phe Lys Cys Glu Asp Cys Gly Lys Arg Leu Val His Arg
            420                 425                 430         
Ser Phe Cys Lys Asp Gln Gln Gly Asp His Asn Gly Glu Asn Ser Ser
        435                 440                 445             
Lys Cys Glu Asp Cys Gly Lys Arg Tyr Lys Arg Arg Leu Asn Leu Asp
    450                 455                 460                 
Ile Ile Leu Ser Leu Phe Leu Asn Asp Met
465                 470                 


<210> 7249
<211> 356
<212> PRT
<213> Homo sapiens

<400> 7249
Met Gly Gly Lys Gly Cys Leu Ser Phe Pro Arg Thr Leu Asp Ser Asn
 1               5                  10                  15      
Pro Arg Gly Glu Gly Asp Thr Pro Ser Gly Pro Val Asn Asn Leu Tyr
            20                  25                  30          
Arg Ile Pro Gln Ser Val Val Asn His Ile Asp Tyr Phe Arg Leu Glu
        35                  40                  45              
Ala Asp Arg Leu Arg Leu Asp Val Asn Ser Ala Thr Arg Ser Gln Lys
    50                  55                  60                  
Leu Gly Trp Leu Ser Met Ala Ser Arg Glu Asp Leu Met Lys Met Val
65                  70                  75                  80  
Arg Pro Pro Tyr Ser Tyr Ser Ala Leu Ile Ala Met Ala Ile Gln Ser
                85                  90                  95      
Ala Pro Glu Arg Lys Leu Thr Leu Ser His Ile Tyr Gln Phe Val Ala
            100                 105                 110         
Asp Ser Phe Pro Phe Tyr Gln Arg Ser Lys Ala Gly Trp Gln Asn Ser
        115                 120                 125             
Ile Arg His Asn Leu Ser Leu Asn Asp Cys Phe Lys Lys Val Pro Arg
    130                 135                 140                 
Asp Glu Asp Asp Pro Gly Lys Gly Asn Tyr Trp Thr Leu Asp Pro Asn
145                 150                 155                 160 
Cys Glu Lys Met Phe Asp Asn Gly Asn Phe Arg Arg Lys Arg Lys Arg
                165                 170                 175     
Arg Ser Glu Ala Ser Asn Gly Ser Thr Val Ala Ala Gly Thr Ser Lys
            180                 185                 190         
Ser Glu Glu Gly Leu Ser Ser Gly Leu Gly Ser Gly Val Gly Gly Lys
        195                 200                 205             
Pro Glu Glu Glu Ser Pro Ser Thr Leu Leu Arg Pro Ser His Ser Pro
    210                 215                 220                 
Glu Pro Pro Glu Gly Thr Lys Ser Thr Ala Ser Ser Pro Gly Gly Pro
225                 230                 235                 240 
Met Leu Thr Ser Thr Pro Cys Leu Asn Thr Phe Phe Ser Ser Leu Ser
                245                 250                 255     
Ser Leu Ser Val Ser Ser Ser Val Ser Thr Gln Arg Ala Leu Pro Gly
            260                 265                 270         
Ser Arg His Leu Gly Ile Gln Gly Ala Gln Leu Pro Ser Ser Gly Val
        275                 280                 285             
Phe Ser Pro Thr Ser Ile Ser Glu Ala Ser Ala Asp Thr Leu Gln Leu
    290                 295                 300                 
Ser Asn Ser Thr Ser Asn Ser Thr Gly Gln Arg Ser Ser Tyr Tyr Ser
305                 310                 315                 320 
Pro Phe Pro Ala Ser Thr Ser Gly Gly Gln Ser Ser Pro Phe Ser Ser
                325                 330                 335     
Pro Phe His Asn Phe Ser Met Val Asn Ser Leu Ile Tyr Pro Arg Glu
            340                 345                 350         
Gly Ser Glu Val
        355     


<210> 7250
<211> 279
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 243
<223> Xaa = Any Amino Acid

<400> 7250
Met Asn Glu Asp Asn Asp Glu Leu Thr Ala Gly Lys Lys Met Gly Phe
 1               5                  10                  15      
Gly Phe Val Thr Tyr Thr Thr Val Glu Glu Val Asp Ala Ala Met Asn
            20                  25                  30          
Ala Arg Pro His Glu Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala
        35                  40                  45              
Val Ser Arg Glu Asp Ser Gln Arg Pro Gly Ala His Leu Thr Val Lys
    50                  55                  60                  
Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu
65                  70                  75                  80  
Arg Asp Tyr Phe Glu Leu Cys Gly Lys Met Glu Leu Ile Glu Ile Ile
                85                  90                  95      
Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe
            100                 105                 110         
Asp Asp Tyr Asp Ser Met Asp Lys Thr Val Ile Gln Lys Cys Tyr Thr
        115                 120                 125             
Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Leu Ser Lys Gln Glu
    130                 135                 140                 
Met Ser Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly Ser Gly Asn
145                 150                 155                 160 
Phe Gly Gly Gly His Gly Gly Ser Phe Trp Asn Asp Asn Phe Gly His
                165                 170                 175     
Gly Gly Asn Phe Asn Gly Cys Gly Asp Gly Tyr Asn Gly Phe Gly Asn
            180                 185                 190         
Asp Gly Ser Asn Phe Gly Ser Gly Arg Ser Cys Asn Asp Phe Gly Ser
        195                 200                 205             
Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Ala Gly Asp Phe
    210                 215                 220                 
Gly Gly Arg Asn Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala
225                 230                 235                 240 
Lys Pro Xaa Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Arg Ala
                245                 250                 255     
Met Ala Val Ala Glu Asp Phe Asn Tyr Cys Gln Glu Thr Asn Leu Ser
            260                 265                 270         
Arg Arg Gly Glu Pro Gly Lys
        275                 


<210> 7251
<211> 508
<212> PRT
<213> Homo sapiens

<400> 7251
Met Ala Pro Thr Leu Phe Gln Lys Leu Phe Ser Lys Arg Thr Gly Leu
 1               5                  10                  15      
Gly Ala Pro Gly Arg Asp Ala Arg Asp Pro Asp Cys Gly Phe Ser Trp
            20                  25                  30          
Pro Leu Pro Glu Phe Asp Pro Ser Gln Ile Arg Leu Ile Val Tyr Gln
        35                  40                  45              
Asp Cys Glu Arg Arg Gly Arg Asn Val Leu Phe Asp Ser Ser Val Lys
    50                  55                  60                  
Arg Arg Asn Glu Asp Ile Ser Val Ser Lys Leu Cys Ser Asp Ala Gln
65                  70                  75                  80  
Val Lys Val Phe Gly Lys Cys Cys Gln Leu Lys Pro Gly Gly Asp Ser
                85                  90                  95      
Ser Ser Ser Leu Asp Ser Ser Val Thr Ser Ser Ser Asp Ile Lys Asp
            100                 105                 110         
Gln Cys Leu Lys Tyr Gln Gly Ser Arg Cys Ser Ser Asp Ala Asn Met
        115                 120                 125             
Leu Gly Glu Met Met Phe Gly Ser Val Ala Met Ser Tyr Lys Gly Ser
    130                 135                 140                 
Thr Leu Lys Ile His Gln Ile Arg Ser Pro Pro Gln Leu Met Leu Ser
145                 150                 155                 160 
Lys Val Phe Thr Ala Arg Thr Gly Ser Ser Ile Cys Gly Ser Leu Asn
                165                 170                 175     
Thr Leu Gln Asp Ser Leu Glu Phe Ile Asn Gln Asp Asn Asn Thr Leu
            180                 185                 190         
Lys Ala Asp Asn Asn Thr Val Ile Asn Gly Leu Leu Gly Asn Ile Gly
        195                 200                 205             
Leu Ser Gln Phe Cys Ser Pro Arg Arg Ala Phe Ser Glu Gln Gly Pro
    210                 215                 220                 
Leu Arg Leu Ile Arg Ser Ala Ser Phe Phe Ala Val His Ser Asn Pro
225                 230                 235                 240 
Met Asp Met Pro Gly Arg Glu Leu Asn Glu Asp Arg Asp Ser Gly Ile
                245                 250                 255     
Ala Arg Ser Ala Ser Leu Ser Ser Leu Leu Ile Thr Pro Phe Pro Ser
            260                 265                 270         
Pro Asn Ser Ser Leu Thr Arg Ser Cys Ala Ser Ser Tyr Gln Arg Arg
        275                 280                 285             
Trp Arg Arg Ser Gln Thr Thr Ser Leu Glu Asn Gly Val Phe Pro Arg
    290                 295                 300                 
Trp Ser Ile Glu Glu Ser Phe Asn Leu Ser Asp Glu Ser Cys Gly Pro
305                 310                 315                 320 
Asn Pro Gly Ile Val Arg Lys Lys Lys Ile Ala Ile Gly Val Ile Phe
                325                 330                 335     
Ser Leu Ser Lys Asp Glu Asp Glu Asn Asn Lys Phe Asn Glu Phe Phe
            340                 345                 350         
Phe Ser His Phe Pro Leu Phe Glu Ser His Met Asn Lys Leu Lys Ser
        355                 360                 365             
Ala Ile Glu Gln Ala Met Lys Met Ser Arg Arg Ser Ala Asp Ala Ser
    370                 375                 380                 
Gln Arg Ser Leu Ala Tyr Asn Arg Ile Val Asp Ala Leu Asn Glu Phe
385                 390                 395                 400 
Arg Thr Thr Ile Cys Asn Leu Tyr Thr Met Pro Arg Ile Gly Glu Pro
                405                 410                 415     
Val Trp Leu Thr Met Met Ser Gly Thr Pro Glu Lys Asn His Leu Cys
            420                 425                 430         
Tyr Arg Phe Met Lys Glu Phe Thr Phe Leu Met Glu Asn Ala Ser Lys
        435                 440                 445             
Asn Gln Phe Leu Pro Ala Leu Ile Thr Ala Val Leu Thr Asn His Leu
    450                 455                 460                 
Ala Trp Val Pro Thr Val Met Pro Asn Gly Gln Pro Pro Ile Lys Ile
465                 470                 475                 480 
Phe Leu Glu Lys His Ser Ser Gln Ser Val Asp Met Leu Ala Lys Thr
                485                 490                 495     
His Pro Tyr Asn Pro Leu Trp Ala Gln Leu Gly Met
            500                 505             


<210> 7252
<211> 943
<212> PRT
<213> Homo sapiens

<400> 7252
Asn Asn Thr Val Ile Asn Gly Leu Leu Gly Asn Ile Val His Ser Asn
 1               5                  10                  15      
Pro Met Asp Met Pro Gly Arg Glu Leu Asn Glu Asp Arg Asp Ser Gly
            20                  25                  30          
Ile Ala Arg Ser Ala Ser Leu Ser Ser Leu Leu Ile Thr Pro Phe Pro
        35                  40                  45              
Ser Pro Asn Ser Ser Leu Thr Arg Ser Cys Ala Ser Ser Tyr Gln Arg
    50                  55                  60                  
Arg Trp Arg Arg Ser Gln Thr Thr Ser Leu Glu Asn Gly Val Phe Pro
65                  70                  75                  80  
Arg Trp Ser Ile Glu Glu Ser Phe Asn Leu Ser Asp Glu Ser Cys Gly
                85                  90                  95      
Pro Asn Pro Gly Ile Val Arg Lys Lys Lys Ile Ala Ile Gly Val Ile
            100                 105                 110         
Phe Ser Leu Ser Lys Asp Glu Asp Glu Asn Asn Lys Phe Asn Glu Phe
        115                 120                 125             
Phe Phe Ser His Phe Pro Leu Phe Glu Ser His Met Asn Lys Leu Lys
    130                 135                 140                 
Ser Ala Ile Glu Gln Ala Met Lys Met Ser Arg Arg Ser Ala Asp Ala
145                 150                 155                 160 
Ser Gln Arg Ser Leu Ala Tyr Asn Arg Ile Val Asp Ala Leu Asn Glu
                165                 170                 175     
Phe Arg Thr Thr Ile Cys Asn Leu Tyr Thr Met Pro Arg Ile Gly Glu
            180                 185                 190         
Pro Val Trp Leu Thr Met Met Ser Gly Thr Pro Glu Lys Asn His Leu
        195                 200                 205             
Cys Tyr Arg Phe Met Lys Glu Phe Thr Phe Leu Met Glu Asn Ala Ser
    210                 215                 220                 
Lys Asn Gln Phe Leu Pro Ala Leu Ile Thr Ala Val Leu Thr Asn His
225                 230                 235                 240 
Leu Ala Trp Val Pro Thr Val Met Pro Asn Gly Gln Pro Pro Ile Lys
                245                 250                 255     
Ile Phe Leu Glu Lys His Ser Ser Gln Ser Val Asp Met Leu Ala Lys
            260                 265                 270         
Thr His Pro Tyr Asn Pro Leu Trp Ala Gln Leu Gly Asp Leu Tyr Gly
        275                 280                 285             
Ala Ile Gly Ser Pro Val Arg Leu Ala Arg Thr Val Val Val Gly Lys
    290                 295                 300                 
Arg Gln Asp Met Val Gln Arg Leu Leu Tyr Phe Leu Thr Tyr Phe Ile
305                 310                 315                 320 
Arg Cys Ser Glu Leu Gln Glu Thr His Leu Leu Glu Asn Gly Glu Asp
                325                 330                 335     
Glu Ala Ile Val Met Pro Gly Thr Val Ile Thr Thr Thr Leu Glu Lys
            340                 345                 350         
Gly Glu Ile Glu Glu Ser Glu Tyr Val Leu Val Thr Met His Arg Asn
        355                 360                 365             
Lys Ser Ser Leu Leu Phe Lys Glu Ser Glu Glu Ile Arg Thr Pro Asn
    370                 375                 380                 
Cys Asn Cys Lys Tyr Cys Ser His Pro Leu Leu Gly Gln Asn Val Glu
385                 390                 395                 400 
Asn Ile Ser Gln Gln Glu Arg Glu Asp Ile Gln Asn Ser Ser Lys Glu
                405                 410                 415     
Leu Leu Gly Ile Ser Asp Glu Cys Arg Met Ile Ser Pro Ser Asp Cys
            420                 425                 430         
Gln Glu Glu Asn Ala Val Asp Val Lys Gln Tyr Arg Asp Lys Leu Arg
        435                 440                 445             
Thr Cys Phe Asp Ala Lys Leu Glu Thr Val Val Cys Thr Gly Ser Val
    450                 455                 460                 
Pro Val Asp Lys Cys Ala Leu Ser Glu Ser Gly Leu Glu Ser Thr Glu
465                 470                 475                 480 
Glu Thr Trp Gln Ser Glu Lys Leu Leu Asp Ser Asp Ser His Thr Gly
                485                 490                 495     
Lys Ala Met Arg Ser Thr Gly Met Val Val Glu Lys Lys Pro Pro Asp
            500                 505                 510         
Lys Ile Val Pro Ala Ser Phe Ser Cys Glu Ala Ala Gln Thr Lys Val
        515                 520                 525             
Thr Phe Leu Ile Gly Asp Ser Met Ser Pro Asp Ser Asp Thr Glu Leu
    530                 535                 540                 
Arg Ser Gln Ala Val Val Asp Gln Ile Thr Arg His His Thr Lys Pro
545                 550                 555                 560 
Leu Lys Glu Glu Arg Gly Ala Ile Asp Gln His Gln Glu Thr Lys Gln
                565                 570                 575     
Thr Thr Lys Asp Gln Ser Gly Glu Ser Asp Thr Gln Asn Met Val Ser
            580                 585                 590         
Glu Glu Pro Cys Glu Leu Pro Cys Trp Asn His Ser Asp Pro Glu Ser
        595                 600                 605             
Met Ser Leu Phe Asp Glu Tyr Phe Asn Asp Asp Ser Ile Glu Thr Arg
    610                 615                 620                 
Thr Ile Asp Asp Val Pro Phe Lys Thr Ser Thr Asp Ser Lys Asp His
625                 630                 635                 640 
Cys Cys Met Leu Glu Phe Ser Lys Ile Leu Cys Thr Lys Asn Asn Lys
                645                 650                 655     
Gln Asn Asn Glu Phe Cys Lys Cys Ile Glu Thr Val Pro Gln Asp Ser
            660                 665                 670         
Cys Lys Thr Cys Phe Pro Gln Gln Asp Gln Arg Asp Thr Leu Ser Ile
        675                 680                 685             
Leu Val Pro His Gly Asp Lys Glu Ser Ser Asp Lys Lys Ile Ala Val
    690                 695                 700                 
Gly Thr Glu Trp Asp Ile Pro Arg Asn Glu Ser Ser Asp Ser Ala Leu
705                 710                 715                 720 
Gly Asp Ser Glu Ser Glu Asp Thr Gly His Asp Met Thr Arg Gln Val
                725                 730                 735     
Ser Ser Tyr Tyr Gly Gly Glu Gln Glu Asp Trp Ala Glu Glu Asp Glu
            740                 745                 750         
Ile Pro Phe Pro Gly Ser Lys Leu Ile Glu Val Ser Ala Val Gln Pro
        755                 760                 765             
Asn Ile Ala Asn Phe Gly Arg Ser Leu Leu Gly Gly Tyr Cys Ser Ser
    770                 775                 780                 
Tyr Val Pro Asp Phe Val Leu Gln Gly Ile Gly Ser Asp Glu Arg Phe
785                 790                 795                 800 
Arg Gln Cys Leu Met Ser Asp Leu Ser His Ala Val Gln His Pro Val
                805                 810                 815     
Leu Asp Glu Pro Ile Ala Glu Ala Val Cys Ile Ile Ala Asp Met Asp
            820                 825                 830         
Lys Trp Thr Val Gln Val Ala Ser Ser Gln Arg Arg Val Thr Asp Asn
        835                 840                 845             
Lys Leu Gly Lys Glu Val Leu Val Ser Ser Leu Val Ser Asn Leu Leu
    850                 855                 860                 
His Ser Thr Leu Gln Leu Tyr Lys His Asn Leu Ser Pro Asn Phe Cys
865                 870                 875                 880 
Val Met His Leu Glu Asp Arg Leu Gln Glu Leu Tyr Phe Lys Ser Lys
                885                 890                 895     
Met Leu Ser Glu Tyr Leu Arg Gly Gln Met Arg Val His Val Lys Glu
            900                 905                 910         
Leu Gly Val Val Leu Gly Ile Glu Ser Ser Asp Leu Pro Leu Leu Ala
        915                 920                 925             
Ala Val Ala Ser Thr His Ser Pro Tyr Val Ala Gln Ile Leu Leu
    930                 935                 940             


<210> 7253
<211> 415
<212> PRT
<213> Homo sapiens

<400> 7253
Ile Phe Val Ser Phe His Thr Gly Leu Lys Glu Asp Ile Leu Glu Val
 1               5                  10                  15      
Glu Val Gly Arg Glu Pro Glu Arg Pro Met Ala Gln Arg Tyr Asp Asp
            20                  25                  30          
Leu Pro His Tyr Gly Gly Met Asp Gly Val Gly Ile Pro Ser Thr Met
        35                  40                  45              
Tyr Gly Asp Pro His Ala Ala Arg Ser Met Gln Pro Val His His Leu
    50                  55                  60                  
Asn His Gly Pro Pro Leu His Ser His Gln Tyr Pro His Thr Ala His
65                  70                  75                  80  
Thr Asn Ala Met Ala Pro Ser Met Gly Ser Ser Val Asn Asp Ala Leu
                85                  90                  95      
Lys Arg Asp Lys Asp Ala Ile Tyr Gly His Pro Leu Phe Pro Leu Leu
            100                 105                 110         
Ala Leu Ile Phe Glu Lys Cys Glu Leu Ala Thr Cys Thr Pro Arg Glu
        115                 120                 125             
Pro Gly Val Ala Gly Gly Asp Val Cys Ser Ser Glu Ser Phe Asn Glu
    130                 135                 140                 
Asp Ile Ala Val Phe Ala Lys Gln Ile Arg Ala Glu Lys Pro Leu Phe
145                 150                 155                 160 
Ser Ser Asn Pro Glu Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val
                165                 170                 175     
Leu Arg Phe His Leu Leu Glu Leu Glu Lys Val His Glu Leu Cys Asp
            180                 185                 190         
Asn Phe Cys His Arg Tyr Ile Ser Cys Leu Lys Gly Lys Met Pro Ile
        195                 200                 205             
Asp Leu Val Ile Asp Asp Arg Glu Gly Gly Ser Lys Ser Asp Ser Glu
    210                 215                 220                 
Asp Ile Thr Arg Ser Ala Asn Leu Thr Asp Gln Pro Ser Trp Asn Arg
225                 230                 235                 240 
Asp His Asp Asp Thr Ala Ser Thr Arg Ser Gly Gly Thr Pro Gly Pro
                245                 250                 255     
Ser Ser Gly Gly His Thr Ser His Ser Gly Asp Asn Ser Ser Glu Gln
            260                 265                 270         
Gly Asp Gly Leu Asp Asn Ser Val Ala Ser Pro Ser Thr Gly Asp Asp
        275                 280                 285             
Asp Asp Pro Asp Lys Asp Lys Lys Arg His Lys Lys Arg Gly Ile Phe
    290                 295                 300                 
Pro Lys Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu
305                 310                 315                 320 
Thr His Pro Tyr Pro Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp
                325                 330                 335     
Thr Gly Leu Thr Ile Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg
            340                 345                 350         
Arg Arg Ile Val Gln Pro Met Ile Asp Gln Ser Asn Arg Ala Gly Asn
        355                 360                 365             
Gln Gly Thr Pro Tyr Asn Pro Asp Gly Gln Pro Met Gly Gly Phe Val
    370                 375                 380                 
Met Asp Gly Gln Gln His Met Gly Ile Arg Ala Pro Gly Pro Met Ser
385                 390                 395                 400 
Gly Met Gly Met Asn Met Gly Met Glu Gly Gln Trp His Tyr Met
                405                 410                 415 


<210> 7254
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7254
Met Asp Asp Ser Lys Gln Glu Ser Thr Thr Ser Lys Glu Glu Glu Thr
 1               5                  10                  15      
Asn Ile Ile Ser Ser Ile Val Pro Ser Thr Gln Asp Ile Tyr Gln Arg
            20                  25                  30          
Gln Asn Ser Ser Asp Val His Lys Ser Leu Leu Pro Ala Val Asp Glu
        35                  40                  45              
Thr Thr Cys Gly His Thr His Phe Gln Gln Met Ile Asp Lys Tyr Ile
    50                  55                  60                  
Asn Glu Ala Asn Leu Ile Pro Glu Lys Thr Asp Leu Gln Glu Leu Glu
65                  70                  75                  80  
His Ile Phe Pro Asn Leu His His Gln Leu Phe Lys Pro Leu Glu Pro
                85                  90                  95      
His Pro Asp Phe Asp Leu Ser Ser Ser Ser Ser Gly Ile Ser Pro Asp
            100                 105                 110         
Asn Arg Asp Phe Tyr Gln Arg Ser Asp Ser Ser Ser Glu Ser His Cys
        115                 120                 125             
Ala Thr Gly Leu Ser Lys Ser Thr Val Tyr Phe Thr Ala Leu Arg Arg
    130                 135                 140                 
Thr Ser Met His Ser Ser Leu Asn Thr Ser Pro Asn Gln Gln Pro Asp
145                 150                 155                 160 
Thr Asn Leu Ala His Val Gly Ala His Ser Phe Ala Thr Glu Asn Ile
                165                 170                 175     
Ile Gly Gly Ser Glu Gln Cys Phe Glu Gln Leu Gln Pro Glu Tyr Ser
            180                 185                 190         
Ser Gln Glu Glu Ser Gln His Ala Asp Leu Pro Ser Ile Phe Ser Ile
        195                 200                 205             
Glu Ala Arg Asp Ser Ser Gln Gly Met Lys Asn Gln Asn Tyr Pro Ser
    210                 215                 220                 
Glu Glu His Thr Glu Ile Leu Gln Asn Lys Lys Lys Ile Val His Phe
225                 230                 235                 240 
Gln Leu Ser Ile Gly Asn Leu Ser Ser Val Tyr Ser Ser Ser Asp Glu
                245                 250                 255     
Ala Asn Val Phe Asp Gln Leu Asn Val Gln His Ser Thr Pro Cys Gly
            260                 265                 270         
Ser Asn Ser Ser Glu Cys Ser Thr Lys His Gln Leu Glu Ser Arg Lys
        275                 280                 285             
Glu Ser Met Gly Phe Glu Glu Leu Ser Lys Arg Gly Val Val Thr Met
    290                 295                 300                 
Leu Gln Ser Gln Gly Leu Ile Glu Asp Asn Lys Asn Glu Thr Cys Arg
305                 310                 315                 320 
Val Leu Asp Ile Asn Pro Gln Val Glu Glu Thr Asp Ser Arg Leu Cys
                325                 330                 335     
Val Arg Thr Val Glu Met Gly Thr Ser Ile Gln Ala Pro Tyr Ser Leu
            340                 345                 350         
Thr Thr Gln Asn Glu Lys Tyr Phe Glu Asn Ser Ala Glu Thr Asp Ile
        355                 360                 365             
Pro Lys Ile Thr Lys Lys Leu Ser Gln Leu Gly Glu Ser Glu Leu Phe
    370                 375                 380                 
Ala Ser Ser Gly Ser Phe Ser Leu Gln Ser Ser Ile Pro Val Trp Glu
385                 390                 395                 400 
Thr Glu Thr Gly His Gly Ile Met Glu Glu Pro Glu Leu Thr Leu Ile
                405                 410                 415     
Ser Thr Thr Asp Thr Ser Ile Ala Glu Met Asp Phe Ala Asn Leu Thr
            420                 425                 430         
Leu Glu Glu Lys Ser Glu Asn Glu Ala Lys Cys Phe Phe Gln Val Ser
        435                 440                 445             
Val Phe Leu Pro Leu Val Ser Ala Thr Glu Ala Ser Asp Tyr Pro Ala
    450                 455                 460                 
Val Ser Glu Leu Ser Ile Glu Lys Pro Arg Thr Ala Ser Thr Glu Thr
465                 470                 475                 480 
Pro Arg Arg Leu Thr Pro Val Pro Gly Ser Leu Gln Glu Ala Phe Ile
                485                 490                 495     
Lys Arg Lys Lys Ser Phe Met Glu Arg Ser His Gln Arg Gln Lys Glu
            500                 505                 510         
Ile Arg Asn Lys Ile His Val Ser Glu Asn Ser Gln Ile Lys Thr Val
        515                 520                 525             
Lys Glu Lys Pro Ser Ile Ser Ser Ser Val Ser Arg Leu Lys Gly Val
    530                 535                 540                 
Asn Lys Val Arg Ala Ser Phe Pro Glu Asp Arg Lys Thr Thr Gln Ala
545                 550                 555                 560 
Leu Arg His Gln Arg Gly Leu Arg Leu Tyr Asn Gln Leu Ala Glu Val
                565                 570                 575     
Lys Gln Gln Lys Glu Glu Lys Thr Lys Gln Glu Ala Tyr Ala Gln Asn
            580                 585                 590         
Arg Ala Arg Ala Lys Glu Phe His Lys Lys Thr Leu Glu Lys Leu Arg
        595                 600                 605             
Ala Lys Asn Thr Cys
    610             


<210> 7255
<211> 1012
<212> PRT
<213> Homo sapiens

<400> 7255
Met Ala Glu Ala Ala Leu Glu Ala Val Arg Ser Glu Leu Arg Glu Phe
 1               5                  10                  15      
Pro Ala Ala Ala Arg Glu Leu Cys Val Pro Leu Ala Val Pro Tyr Leu
            20                  25                  30          
Asp Lys Pro Pro Thr Pro Leu His Phe Tyr Arg Asp Trp Val Cys Pro
        35                  40                  45              
Asn Arg Pro Cys Ile Ile Arg Asn Ala Leu Gln His Trp Pro Ala Leu
    50                  55                  60                  
Gln Lys Trp Ser Leu Pro Tyr Phe Arg Ala Thr Val Gly Ser Thr Glu
65                  70                  75                  80  
Val Ser Val Ala Val Thr Pro Asp Gly Tyr Ala Asp Ala Val Arg Gly
                85                  90                  95      
Asp Arg Phe Met Met Pro Ala Glu Arg Arg Leu Pro Leu Ser Phe Val
            100                 105                 110         
Leu Asp Val Leu Glu Gly Arg Ala Gln His Pro Gly Val Leu Tyr Val
        115                 120                 125             
Gln Lys Gln Cys Ser Asn Leu Pro Ser Glu Leu Pro Gln Leu Leu Pro
    130                 135                 140                 
Asp Leu Glu Ser His Val Pro Trp Ala Ser Glu Ala Leu Gly Lys Met
145                 150                 155                 160 
Pro Asp Ala Val Asn Phe Trp Leu Gly Glu Ala Ala Ala Val Thr Ser
                165                 170                 175     
Leu His Lys Asp His Tyr Glu Asn Leu Tyr Cys Val Val Ser Gly Glu
            180                 185                 190         
Lys His Phe Leu Phe His Pro Pro Ser Asp Arg Pro Phe Ile Pro Tyr
        195                 200                 205             
Glu Leu Tyr Thr Pro Ala Thr Tyr Gln Leu Thr Glu Glu Gly Thr Phe
    210                 215                 220                 
Lys Val Val Asp Glu Glu Ala Met Glu Lys Ala Glu Val Ser Arg Thr
225                 230                 235                 240 
Cys Leu Leu Thr Val Arg Val Leu Gln Ala His Arg Leu Pro Ser Lys
                245                 250                 255     
Asp Leu Val Thr Pro Ser Asp Cys Tyr Val Thr Leu Trp Leu Pro Thr
            260                 265                 270         
Ala Cys Ser His Arg Leu Gln Thr Arg Thr Val Lys Asn Ser Ser Ser
        275                 280                 285             
Pro Val Trp Asn Gln Ser Phe His Phe Arg Ile His Arg Gln Leu Lys
    290                 295                 300                 
Asn Val Met Glu Leu Lys Val Phe Asp Gln Asp Leu Val Thr Gly Asp
305                 310                 315                 320 
Asp Pro Val Leu Ser Val Leu Phe Asp Ala Gly Thr Leu Arg Ala Gly
                325                 330                 335     
Glu Phe Arg Arg Glu Ser Phe Ser Leu Ser Pro Gln Gly Glu Gly Arg
            340                 345                 350         
Leu Glu Val Glu Phe Arg Leu Gln Ser Leu Ala Asp Arg Gly Glu Trp
        355                 360                 365             
Leu Val Ser Asn Gly Val Leu Val Ala Arg Glu Leu Ser Cys Leu His
    370                 375                 380                 
Val Gln Leu Glu Glu Thr Gly Asp Gln Lys Ser Ser Glu His Arg Val
385                 390                 395                 400 
Gln Leu Val Val Pro Gly Ser Cys Glu Gly Pro Gln Glu Ala Ser Val
                405                 410                 415     
Gly Thr Gly Thr Phe Arg Phe His Cys Pro Ala Cys Trp Glu Gln Glu
            420                 425                 430         
Leu Ser Ile Arg Leu Gln Asp Ala Pro Glu Glu Gln Leu Lys Ala Pro
        435                 440                 445             
Leu Ser Ala Leu Pro Ser Gly Gln Val Val Arg Leu Val Phe Pro Thr
    450                 455                 460                 
Ser Gln Glu Pro Leu Met Arg Val Glu Leu Lys Lys Glu Ala Gly Leu
465                 470                 475                 480 
Arg Glu Leu Ala Val Arg Leu Gly Phe Gly Pro Cys Ala Glu Glu Gln
                485                 490                 495     
Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala Ala Ala Leu Arg Gln
            500                 505                 510         
Ala Leu Gln Leu Asp Gly Asp Leu Gln Glu Asp Glu Ile Pro Val Val
        515                 520                 525             
Ala Ile Met Ala Thr Gly Gly Gly Ile Arg Ala Met Thr Ser Leu Tyr
    530                 535                 540                 
Gly Gln Leu Ala Gly Leu Lys Glu Leu Gly Leu Leu Asp Cys Val Ser
545                 550                 555                 560 
Tyr Ile Thr Gly Ala Ser Gly Ser Thr Trp Ala Leu Ala Asn Leu Tyr
                565                 570                 575     
Glu Asp Pro Glu Trp Ser Gln Lys Asp Leu Ala Gly Pro Thr Glu Leu
            580                 585                 590         
Leu Lys Thr Gln Val Thr Lys Asn Lys Leu Gly Val Leu Ala Pro Ser
        595                 600                 605             
Gln Leu Gln Arg Tyr Arg Gln Glu Leu Ala Glu Arg Ala Arg Leu Gly
    610                 615                 620                 
Tyr Pro Ser Cys Phe Thr Asn Leu Trp Ala Leu Ile Asn Glu Ala Leu
625                 630                 635                 640 
Leu His Asp Glu Pro His Asp His Lys Leu Ser Asp Gln Arg Glu Ala
                645                 650                 655     
Leu Ser His Gly Gln Asn Pro Leu Pro Ile Tyr Cys Ala Leu Asn Thr
            660                 665                 670         
Lys Gly Gln Ser Leu Thr Thr Phe Glu Phe Gly Glu Trp Cys Glu Phe
        675                 680                 685             
Ser Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala Phe Ile Pro Ser
    690                 695                 700                 
Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Gln Leu Met Lys Arg Leu
705                 710                 715                 720 
Pro Glu Ser Arg Ile Cys Phe Leu Glu Gly Ile Trp Ser Asn Leu Tyr
                725                 730                 735     
Ala Ala Asn Leu Gln Asp Ser Leu Tyr Trp Ala Ser Glu Pro Ser Gln
            740                 745                 750         
Phe Trp Asp Arg Trp Val Arg Asn Gln Ala Asn Leu Asp Lys Glu Gln
        755                 760                 765             
Val Pro Leu Leu Lys Ile Glu Glu Pro Pro Ser Thr Ala Gly Arg Ile
    770                 775                 780                 
Ala Glu Phe Phe Thr Asp Leu Leu Thr Trp Arg Pro Leu Ala Gln Ala
785                 790                 795                 800 
Thr His Asn Phe Leu Arg Gly Leu His Phe His Lys Asp Tyr Phe Gln
                805                 810                 815     
His Pro His Phe Ser Thr Trp Lys Ala Thr Thr Leu Asp Gly Leu Pro
            820                 825                 830         
Asn Gln Leu Thr Pro Ser Glu Pro His Leu Cys Leu Leu Asp Val Gly
        835                 840                 845             
Tyr Leu Ile Asn Thr Ser Cys Leu Pro Leu Leu Gln Pro Thr Arg Asp
    850                 855                 860                 
Val Asp Leu Ile Leu Ser Leu Asp Tyr Asn Leu His Gly Ala Phe Gln
865                 870                 875                 880 
Gln Leu Gln Leu Leu Gly Arg Phe Cys Gln Glu Gln Gly Ile Pro Phe
                885                 890                 895     
Pro Pro Ile Ser Pro Ser Pro Glu Glu Gln Leu Gln Pro Arg Glu Cys
            900                 905                 910         
His Thr Phe Ser Asp Pro Thr Cys Pro Gly Ala Pro Ala Val Leu His
        915                 920                 925             
Phe Pro Leu Val Ser Asp Ser Phe Arg Glu Tyr Ser Ala Pro Gly Val
    930                 935                 940                 
Arg Arg Thr Pro Glu Glu Ala Ala Ala Gly Glu Val Asn Leu Ser Ser
945                 950                 955                 960 
Ser Asp Ser Pro Tyr His Tyr Thr Lys Val Thr Tyr Ser Gln Glu Asp
                965                 970                 975     
Val Asp Lys Leu Leu His Leu Thr His Tyr Asn Val Cys Asn Asn Gln
            980                 985                 990         
Glu Gln Leu Leu Glu Ala Leu Arg Gln Ala Val Gln Arg Arg Arg Gln
        995                 1000                1005            
Arg Arg Pro His
    1010        


<210> 7256
<211> 2525
<212> PRT
<213> Homo sapiens

<400> 7256
Arg Leu Arg Leu Gln Cys Ile Ser Ile Val Thr Gly Arg Gly Gly Ala
 1               5                  10                  15      
Gln Ile Gly Ala Gln Gln Ser Gln Lys Pro Thr Arg Arg Ser Ser Glu
            20                  25                  30          
Asn Met Thr Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Thr Leu Val
        35                  40                  45              
Gln Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu
    50                  55                  60                  
Thr Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Thr Asp Lys Ile
65                  70                  75                  80  
Ser Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu
                85                  90                  95      
Gly Thr Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser
            100                 105                 110         
Lys Arg Lys Pro Ser Ile Val Thr Lys Tyr Val Glu Ser Asp Asp Glu
        115                 120                 125             
Lys Pro Leu Asp Asp Glu Thr Val Asn Glu Asp Ala Ser Asn Glu Asn
    130                 135                 140                 
Ser Glu Asn Asp Ile Thr Met Gln Ser Leu Pro Lys Gly Thr Val Ile
145                 150                 155                 160 
Val Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly
                165                 170                 175     
Pro Glu Phe Arg Ser Arg Ser Lys Met Lys Thr Glu Asn Leu Lys Lys
            180                 185                 190         
Arg Gly Glu Asp Gly Leu His Gly Ile Val Ser Cys Thr Ala Cys Gly
        195                 200                 205             
Gln Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His Pro Ser
    210                 215                 220                 
Leu Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp
225                 230                 235                 240 
Asp Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys Arg Trp Cys
                245                 250                 255     
Ala Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His Asn Ala Phe
            260                 265                 270         
Cys Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu Leu Ser Thr
        275                 280                 285             
Ile Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu
    290                 295                 300                 
Pro Leu Leu Asp Leu Val Thr Ala Cys Asn Ser Val Phe Glu Asn Leu
305                 310                 315                 320 
Glu Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys Val Asp Ser Glu
                325                 330                 335     
Lys Ser Asn Lys Val Tyr Glu His Thr Ser Arg Phe Ser Pro Lys Lys
            340                 345                 350         
Thr Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys
        355                 360                 365             
Ser Gly Ser Val Thr Tyr Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu
    370                 375                 380                 
Met Ile Lys Lys Ala Lys Lys Leu Ile Glu Thr Thr Ala Asn Met Asn
385                 390                 395                 400 
Ser Ser Tyr Val Lys Phe Leu Lys Gln Ala Thr Asp Asn Ser Glu Ile
                405                 410                 415     
Ser Ser Ala Thr Lys Leu Arg Gln Leu Lys Ala Phe Lys Ser Val Leu
            420                 425                 430         
Ala Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu Asp Leu Asn Ser
        435                 440                 445             
Glu Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys Asn Thr Lys Glu
    450                 455                 460                 
His Lys Val Ile Asp Ala Lys Phe Glu Thr Lys Ala Arg Lys Gly Glu
465                 470                 475                 480 
Lys Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys
                485                 490                 495     
Leu Ser Arg Lys Gln Val Asp Ser Glu His Met His Gln Asn Val Pro
            500                 505                 510         
Thr Glu Glu Gln Arg Thr Asn Lys Ser Thr Gly Gly Glu His Lys Lys
        515                 520                 525             
Ser Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala Asn Thr Ser Glu
    530                 535                 540                 
Asp Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser Val Pro Glu Asp
545                 550                 555                 560 
Ile Phe Glu Asn Leu Glu Thr Ala Met Glu Val Gln Ser Ser Val Asp
                565                 570                 575     
His Gln Gly Asp Gly Ser Ser Gly Thr Glu Gln Glu Val Glu Ser Ser
            580                 585                 590         
Ser Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg Gly Gly Ile Lys
        595                 600                 605             
Ser Lys Thr Thr Ala Lys Val Thr Lys Glu Leu Tyr Val Lys Leu Thr
    610                 615                 620                 
Pro Val Ser Leu Ser Asn Ser Pro Ile Lys Gly Ala Asp Cys Gln Glu
625                 630                 635                 640 
Val Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys
                645                 650                 655     
Leu Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp Asn Glu His Leu
            660                 665                 670         
Val Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg
        675                 680                 685             
Ser Pro Arg Val Lys Thr Thr Pro Leu Arg Arg Pro Thr Glu Thr Asn
    690                 695                 700                 
Pro Val Thr Ser Asn Ser Asp Glu Glu Cys Asn Glu Thr Val Lys Glu
705                 710                 715                 720 
Lys Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp Lys Arg Asn Ser
                725                 730                 735     
Ser Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser
            740                 745                 750         
Lys Gln Ser Glu Thr Val Asp Gln Asn Ser Asp Ser Asp Glu Met Leu
        755                 760                 765             
Ala Ile Leu Lys Glu Val Ser Arg Met Ser His Ser Ser Ser Ser Asp
    770                 775                 780                 
Thr Asp Ile Asn Glu Ile His Thr Asn His Lys Thr Leu Tyr Asp Leu
785                 790                 795                 800 
Lys Thr Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser
                805                 810                 815     
Ser Thr Ser Gly Ser Asp Phe Asp Thr Lys Lys Gly Lys Ser Ala Lys
            820                 825                 830         
Ser Ser Ile Ile Ser Lys Lys Lys Arg Gln Thr Gln Ser Glu Ser Ser
        835                 840                 845             
Asn Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser Met Ser Lys Ile
    850                 855                 860                 
Gly Ala Ala Arg Thr Thr Lys Lys Arg Ile Pro Asn Thr Lys Asp Phe
865                 870                 875                 880 
Asp Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly Met Asp Asn Gln
                885                 890                 895     
Gly His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser Ser Asp Asp Ala
            900                 905                 910         
Glu Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala Glu Gly Thr Val
        915                 920                 925             
Asp Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg Leu Pro Lys Lys
    930                 935                 940                 
Gln Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys Leu Ser Gly Lys
945                 950                 955                 960 
Glu Gln Ser Phe Thr Ser Leu Glu Val Arg Lys Val Ala Glu Thr Lys
                965                 970                 975     
Glu Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys Lys Val Gln Asp
            980                 985                 990         
Gly Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp
        995                 1000                1005            
Glu Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys Gly Thr Glu Glu
    1010                1015                1020                
Lys Lys Lys Pro Ser Asp Phe Lys Lys Lys Val Ile Lys Met Glu Gln
1025                1030                1035                1040
Gln Tyr Glu Ser Ser Ser Asp Gly Thr Glu Lys Leu Pro Glu Arg Glu
                1045                1050                1055    
Glu Ile Cys His Phe Pro Lys Gly Ile Lys Gln Ile Lys Asn Gly Thr
            1060                1065                1070        
Thr Asp Gly Glu Lys Lys Ser Lys Lys Ile Arg Asp Lys Thr Ser Lys
        1075                1080                1085            
Lys Lys Asp Glu Leu Ser Asp Tyr Ala Glu Lys Ser Thr Gly Lys Gly
    1090                1095                1100                
Asp Ser Cys Asp Ser Ser Glu Asp Lys Lys Ser Lys Asn Gly Ala Tyr
1105                1110                1115                1120
Gly Arg Glu Lys Lys Arg Cys Lys Leu Leu Gly Lys Ser Ser Arg Lys
                1125                1130                1135    
Arg Gln Asp Cys Ser Ser Ser Asp Thr Glu Lys Tyr Ser Met Lys Glu
            1140                1145                1150        
Asp Gly Cys Asn Ser Ser Asp Lys Arg Leu Lys Arg Ile Glu Leu Arg
        1155                1160                1165            
Glu Arg Arg Asn Leu Ser Ser Lys Arg Asn Thr Lys Glu Ile Gln Ser
    1170                1175                1180                
Gly Ser Ser Ser Ser Asp Ala Glu Glu Ser Ser Glu Asp Asn Lys Lys
1185                1190                1195                1200
Lys Lys Gln Arg Thr Ser Ser Lys Lys Lys Ala Val Ile Val Lys Glu
                1205                1210                1215    
Lys Lys Arg Asn Ser Leu Arg Thr Ser Thr Lys Arg Lys Gln Ala Asp
            1220                1225                1230        
Ile Thr Ser Ser Ser Ser Ser Asp Ile Glu Asp Asp Asp Gln Asn Ser
        1235                1240                1245            
Ile Gly Glu Gly Ser Ser Asp Glu Gln Lys Ile Lys Pro Val Thr Glu
    1250                1255                1260                
Asn Leu Val Leu Ser Ser His Thr Gly Phe Cys Gln Ser Ser Gly Asp
1265                1270                1275                1280
Glu Ala Leu Ser Lys Ser Val Pro Val Thr Val Asp Asp Asp Asp Asp
                1285                1290                1295    
Asp Asn Asp Pro Glu Asn Arg Ile Ala Lys Lys Met Leu Leu Glu Glu
            1300                1305                1310        
Ile Lys Ala Asn Leu Ser Ser Asp Glu Asp Gly Ser Ser Asp Asp Glu
        1315                1320                1325            
Pro Glu Glu Gly Lys Lys Arg Thr Gly Lys Gln Asn Glu Glu Asn Pro
    1330                1335                1340                
Gly Asp Glu Glu Ala Lys Asn Gln Val Asn Ser Glu Ser Asp Ser Asp
1345                1350                1355                1360
Ser Glu Glu Ser Lys Lys Pro Arg Tyr Arg His Arg Leu Leu Arg His
                1365                1370                1375    
Lys Leu Thr Val Ser Asp Gly Glu Ser Gly Glu Glu Lys Lys Thr Lys
            1380                1385                1390        
Pro Lys Glu His Lys Glu Val Lys Gly Arg Asn Arg Arg Lys Val Ser
        1395                1400                1405            
Ser Glu Asp Ser Glu Asp Ser Asp Phe Gln Glu Ser Gly Val Ser Glu
    1410                1415                1420                
Glu Val Ser Glu Ser Glu Asp Glu Gln Arg Pro Arg Thr Arg Ser Ala
1425                1430                1435                1440
Lys Lys Ala Glu Leu Glu Glu Asn Gln Arg Ser Tyr Lys Gln Lys Lys
                1445                1450                1455    
Lys Arg Arg Arg Ile Lys Val Gln Glu Asp Ser Ser Ser Glu Asn Lys
            1460                1465                1470        
Ser Asn Ser Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu
        1475                1480                1485            
Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asn Asp Asp Ser Lys
    1490                1495                1500                
Ser Pro Gly Lys Gly Arg Lys Lys Ile Arg Lys Ile Leu Lys Asp Asp
1505                1510                1515                1520
Lys Leu Arg Thr Glu Thr Gln Asn Ala Leu Lys Glu Glu Glu Glu Arg
                1525                1530                1535    
Arg Lys Arg Ile Ala Glu Arg Glu Arg Glu Arg Glu Lys Leu Arg Glu
            1540                1545                1550        
Val Ile Glu Ile Glu Asp Ala Ser Pro Thr Lys Cys Pro Ile Thr Thr
        1555                1560                1565            
Lys Leu Val Leu Asp Glu Asp Glu Glu Thr Lys Glu Pro Leu Val Gln
    1570                1575                1580                
Val His Arg Asn Met Val Ile Lys Leu Lys Pro His Gln Val Asp Gly
1585                1590                1595                1600
Val Gln Phe Met Trp Asp Cys Cys Cys Glu Ser Val Lys Lys Thr Lys
                1605                1610                1615    
Lys Ser Pro Gly Ser Gly Cys Ile Leu Ala His Cys Met Gly Leu Gly
            1620                1625                1630        
Lys Thr Leu Gln Val Val Ser Phe Leu His Thr Val Leu Leu Cys Asp
        1635                1640                1645            
Lys Leu Asp Phe Ser Thr Ala Leu Val Val Cys Pro Leu Asn Thr Ala
    1650                1655                1660                
Leu Asn Trp Met Asn Glu Phe Glu Lys Trp Gln Glu Gly Leu Lys Asp
1665                1670                1675                1680
Asp Glu Lys Leu Glu Val Ser Glu Leu Ala Thr Val Lys Arg Pro Gln
                1685                1690                1695    
Glu Arg Ser Tyr Met Leu Gln Arg Trp Gln Glu Asp Gly Gly Val Met
            1700                1705                1710        
Ile Ile Gly Tyr Glu Met Tyr Arg Asn Leu Ala Gln Gly Arg Asn Val
        1715                1720                1725            
Lys Ser Arg Lys Leu Lys Glu Ile Phe Asn Lys Ala Leu Val Asp Pro
    1730                1735                1740                
Gly Pro Asp Phe Val Val Cys Asp Glu Gly His Ile Leu Lys Asn Glu
1745                1750                1755                1760
Ala Ser Ala Val Ser Lys Ala Met Asn Ser Ile Arg Ser Arg Arg Arg
                1765                1770                1775    
Ile Ile Leu Thr Gly Thr Pro Leu Gln Asn Asn Leu Ile Glu Tyr His
            1780                1785                1790        
Cys Met Val Asn Phe Ile Lys Glu Asn Leu Leu Gly Ser Ile Lys Glu
        1795                1800                1805            
Phe Arg Asn Arg Phe Ile Asn Pro Ile Gln Asn Gly Gln Cys Ala Asp
    1810                1815                1820                
Ser Thr Met Val Asp Val Arg Val Met Lys Lys Arg Ala His Ile Leu
1825                1830                1835                1840
Tyr Glu Met Leu Ala Gly Cys Val Gln Arg Lys Asp Tyr Thr Ala Leu
                1845                1850                1855    
Thr Lys Phe Leu Pro Pro Lys His Glu Tyr Val Leu Ala Val Arg Met
            1860                1865                1870        
Thr Ser Ile Gln Cys Lys Leu Tyr Gln Tyr Tyr Leu Asp His Leu Thr
        1875                1880                1885            
Gly Val Gly Asn Asn Ser Glu Gly Gly Arg Gly Lys Ala Gly Ala Lys
    1890                1895                1900                
Leu Phe Gln Asp Phe Gln Met Leu Ser Arg Ile Trp Thr His Pro Trp
1905                1910                1915                1920
Cys Leu Gln Leu Asp Tyr Ile Ser Lys Glu Asn Lys Gly Tyr Phe Asp
                1925                1930                1935    
Glu Asp Ser Met Asp Glu Phe Ile Ala Ser Asp Ser Asp Glu Thr Ser
            1940                1945                1950        
Met Ser Leu Ser Ser Asp Asp Tyr Thr Lys Lys Lys Lys Lys Gly Lys
        1955                1960                1965            
Lys Gly Lys Lys Asp Ser Ser Ser Ser Gly Ser Gly Ser Asp Asn Asp
    1970                1975                1980                
Val Glu Val Ile Lys Val Trp Asn Ser Arg Ser Arg Gly Gly Gly Glu
1985                1990                1995                2000
Gly Asn Val Asp Glu Thr Gly Asn Asn Pro Ser Val Ser Leu Lys Leu
                2005                2010                2015    
Glu Glu Ser Lys Ala Thr Ser Ser Ser Asn Pro Ser Ser Pro Ala Pro
            2020                2025                2030        
Asp Trp Tyr Lys Asp Phe Val Thr Asp Ala Asp Ala Glu Val Leu Glu
        2035                2040                2045            
His Ser Gly Lys Met Val Leu Leu Phe Glu Ile Leu Arg Met Ala Glu
    2050                2055                2060                
Glu Ile Gly Asp Lys Val Leu Val Phe Ser Gln Ser Leu Ile Ser Leu
2065                2070                2075                2080
Asp Leu Ile Glu Asp Phe Leu Glu Leu Ala Ser Arg Glu Lys Thr Glu
                2085                2090                2095    
Asp Lys Asp Lys Pro Leu Ile Tyr Lys Gly Glu Gly Lys Trp Leu Arg
            2100                2105                2110        
Asn Ile Asp Tyr Tyr Arg Leu Asp Gly Ser Thr Thr Ala Gln Ser Arg
        2115                2120                2125            
Lys Lys Trp Ala Glu Glu Phe Asn Asp Glu Thr Asn Val Arg Gly Arg
    2130                2135                2140                
Leu Phe Ile Ile Ser Thr Lys Ala Gly Ser Leu Gly Ile Asn Leu Val
2145                2150                2155                2160
Ala Ala Asn Arg Val Ile Ile Phe Asp Ala Ser Trp Asn Pro Ser Tyr
                2165                2170                2175    
Asp Ile Gln Ser Ile Phe Arg Val Tyr Arg Phe Gly Gln Thr Lys Pro
            2180                2185                2190        
Val Tyr Val Tyr Arg Phe Leu Ala Gln Gly Thr Met Glu Asp Lys Ile
        2195                2200                2205            
Tyr Asp Arg Gln Val Thr Lys Gln Ser Leu Ser Phe Arg Val Val Asp
    2210                2215                2220                
Gln Gln Gln Val Glu Arg His Phe Thr Met Asn Glu Leu Thr Glu Leu
2225                2230                2235                2240
Tyr Thr Phe Glu Pro Asp Leu Leu Asp Asp Pro Asn Ser Glu Lys Lys
                2245                2250                2255    
Lys Lys Arg Asp Thr Pro Met Leu Pro Lys Asp Thr Ile Leu Ala Glu
            2260                2265                2270        
Leu Leu Gln Ile His Lys Glu His Ile Val Gly Tyr His Glu His Asp
        2275                2280                2285            
Ser Leu Leu Asp His Lys Glu Glu Glu Glu Leu Thr Glu Glu Glu Arg
    2290                2295                2300                
Lys Ala Ala Trp Ala Glu Tyr Glu Ala Glu Lys Lys Gly Leu Thr Met
2305                2310                2315                2320
Arg Phe Asn Ile Pro Thr Gly Thr Asn Leu Pro Pro Val Ser Phe Asn
                2325                2330                2335    
Ser Gln Thr Pro Tyr Ile Pro Phe Asn Leu Gly Ala Leu Ser Ala Met
            2340                2345                2350        
Ser Asn Gln Gln Leu Glu Asp Leu Ile Asn Gln Gly Arg Glu Lys Val
        2355                2360                2365            
Val Glu Ala Thr Asn Ser Val Thr Ala Val Arg Ile Gln Pro Leu Glu
    2370                2375                2380                
Asp Ile Ile Ser Ala Val Trp Lys Glu Asn Met Asn Leu Ser Glu Ala
2385                2390                2395                2400
Gln Val Gln Ala Leu Ala Leu Ser Arg Gln Ala Ser Gln Glu Leu Asp
                2405                2410                2415    
Val Lys Arg Arg Glu Ala Ile Tyr Asn Asp Val Leu Thr Lys Gln Gln
            2420                2425                2430        
Met Leu Ile Ser Cys Val Gln Arg Ile Leu Met Asn Arg Arg Leu Gln
        2435                2440                2445            
Gln Gln Tyr Asn Gln Gln Gln Gln Gln Gln Met Thr Tyr Gln Gln Ala
    2450                2455                2460                
Thr Leu Gly His Leu Met Met Pro Lys Pro Pro Asn Leu Ile Met Asn
2465                2470                2475                2480
Pro Ser Asn Tyr Gln Gln Ile Asp Met Arg Gly Met Tyr Gln Pro Val
                2485                2490                2495    
Ala Gly Gly Met Gln Pro Pro Pro Leu Gln Arg Ala Pro Pro Pro Met
            2500                2505                2510        
Arg Ser Lys Asn Pro Gly Pro Ser Gln Gly Lys Ser Met
        2515                2520                2525


<210> 7257
<211> 1972
<212> PRT
<213> Homo sapiens

<400> 7257
Met Asp Pro Thr Gly Ser Gln Leu Asp Ser Asp Phe Ser Gln Gln Asp
 1               5                  10                  15      
Thr Pro Cys Leu Ile Ile Glu Asp Ser Gln Pro Glu Ser Gln Val Leu
            20                  25                  30          
Glu Asp Asp Ser Gly Ser His Phe Ser Met Leu Ser Arg His Leu Pro
        35                  40                  45              
Asn Leu Gln Thr His Lys Glu Asn Pro Val Leu Asp Val Val Ser Asn
    50                  55                  60                  
Pro Glu Gln Thr Ala Gly Glu Glu Arg Gly Asp Gly Asn Ser Gly Phe
65                  70                  75                  80  
Asn Glu His Leu Lys Glu Asn Lys Val Ala Asp Pro Val Asp Ser Ser
                85                  90                  95      
Asn Leu Asp Thr Cys Gly Ser Ile Ser Gln Val Ile Glu Gln Leu Pro
            100                 105                 110         
Gln Pro Asn Arg Thr Ser Ser Val Leu Gly Met Ser Val Glu Ser Ala
        115                 120                 125             
Pro Ala Val Glu Glu Glu Lys Gly Glu Glu Leu Glu Gln Lys Glu Lys
    130                 135                 140                 
Glu Lys Glu Glu Asp Thr Ser Gly Asn Thr Thr His Ser Leu Gly Ala
145                 150                 155                 160 
Glu Asp Thr Ala Ser Ser Gln Leu Gly Phe Gly Val Leu Glu Leu Ser
                165                 170                 175     
Gln Ser Gln Asp Val Glu Glu Asn Thr Val Pro Tyr Glu Val Asp Lys
            180                 185                 190         
Glu Gln Leu Gln Ser Val Thr Thr Asn Ser Gly Tyr Thr Arg Leu Ser
        195                 200                 205             
Asp Val Asp Ala Asn Thr Ala Ile Lys His Glu Glu Gln Ser Asn Glu
    210                 215                 220                 
Asp Ile Pro Ile Ala Glu Gln Ser Ser Lys Asp Ile Pro Val Thr Ala
225                 230                 235                 240 
Gln Pro Ser Lys Asp Val His Val Val Lys Glu Gln Asn Pro Pro Pro
                245                 250                 255     
Ala Arg Ser Glu Asp Met Pro Phe Ser Pro Lys Ala Ser Val Ala Ala
            260                 265                 270         
Met Glu Ala Lys Glu Gln Leu Ser Ala Gln Glu Leu Met Glu Ser Gly
        275                 280                 285             
Leu Gln Ile Gln Lys Ser Pro Glu Pro Glu Val Leu Ser Thr Gln Glu
    290                 295                 300                 
Asp Leu Phe Asp Gln Ser Asn Lys Thr Val Ser Ser Asp Gly Cys Ser
305                 310                 315                 320 
Thr Pro Ser Arg Glu Glu Gly Gly Cys Ser Leu Ala Ser Thr Pro Ala
                325                 330                 335     
Thr Thr Leu His Leu Leu Gln Leu Ser Gly Gln Arg Ser Leu Val Gln
            340                 345                 350         
Asp Ser Leu Ser Thr Asn Ser Ser Asp Leu Val Ala Pro Ser Pro Asp
        355                 360                 365             
Ala Phe Arg Ser Thr Pro Phe Ile Val Pro Ser Ser Pro Thr Glu Gln
    370                 375                 380                 
Glu Gly Arg Gln Asp Lys Pro Met Asp Thr Ser Val Leu Ser Glu Glu
385                 390                 395                 400 
Gly Gly Glu Pro Phe Gln Lys Lys Leu Gln Ser Gly Glu Pro Val Glu
                405                 410                 415     
Leu Glu Asn Pro Pro Leu Leu Pro Glu Ser Thr Val Ser Pro Gln Ala
            420                 425                 430         
Ser Thr Pro Ile Ser Gln Ser Thr Pro Val Phe Pro Pro Gly Ser Leu
        435                 440                 445             
Pro Ile Pro Ser Gln Pro Gln Phe Ser His Asp Ile Phe Ile Pro Ser
    450                 455                 460                 
Pro Ser Leu Glu Glu Gln Ser Asn Asp Gly Lys Lys Asp Gly Asp Met
465                 470                 475                 480 
His Ser Ser Ser Leu Thr Val Glu Cys Ser Lys Thr Ser Glu Ile Glu
                485                 490                 495     
Pro Lys Asn Ser Pro Glu Asp Leu Gly Leu Ser Leu Thr Gly Asp Ser
            500                 505                 510         
Cys Lys Leu Met Leu Ser Thr Ser Glu Tyr Ser Gln Ser Pro Lys Met
        515                 520                 525             
Glu Ser Leu Ser Ser His Arg Ile Asp Glu Asp Gly Glu Asn Thr Gln
    530                 535                 540                 
Ile Glu Asp Thr Glu Pro Met Ser Pro Val Leu Asn Ser Lys Phe Val
545                 550                 555                 560 
Pro Ala Glu Asn Asp Ser Ile Leu Met Asn Pro Ala Gln Asp Gly Glu
                565                 570                 575     
Val Gln Leu Ser Gln Asn Asp Asp Lys Thr Lys Gly Asp Asp Thr Asp
            580                 585                 590         
Thr Arg Asp Asp Ile Ser Ile Leu Ala Thr Gly Cys Lys Gly Arg Glu
        595                 600                 605             
Glu Thr Val Ala Glu Asp Val Cys Ile Asp Leu Thr Cys Asp Ser Gly
    610                 615                 620                 
Ser Gln Ala Val Pro Ser Pro Ala Thr Arg Ser Glu Ala Leu Ser Ser
625                 630                 635                 640 
Val Leu Asp Gln Glu Glu Ala Met Glu Ile Lys Glu His His Pro Glu
                645                 650                 655     
Glu Gly Ser Ser Gly Ser Glu Val Glu Glu Ile Pro Glu Thr Pro Cys
            660                 665                 670         
Glu Ser Gln Gly Glu Glu Leu Lys Glu Glu Asn Met Glu Ser Val Pro
        675                 680                 685             
Leu His Leu Ser Leu Thr Glu Thr Gln Ser Gln Gly Leu Cys Leu Gln
    690                 695                 700                 
Lys Glu Met Pro Lys Lys Glu Cys Ser Glu Ala Met Glu Val Glu Thr
705                 710                 715                 720 
Ser Val Ile Ser Ile Asp Ser Pro Gln Lys Leu Ala Ile Leu Asp Gln
                725                 730                 735     
Glu Leu Glu His Lys Glu Gln Glu Ala Trp Glu Glu Ala Thr Ser Glu
            740                 745                 750         
Asp Ser Ser Val Val Ile Val Asp Val Lys Glu Pro Ser Pro Arg Val
        755                 760                 765             
Asp Val Ser Cys Glu Pro Leu Glu Gly Val Glu Lys Cys Ser Asp Ser
    770                 775                 780                 
Gln Ser Trp Glu Asp Ile Ala Pro Glu Ile Glu Pro Cys Ala Glu Asn
785                 790                 795                 800 
Arg Leu Asp Thr Lys Glu Glu Lys Ser Val Glu Tyr Glu Gly Asp Leu
                805                 810                 815     
Lys Ser Gly Thr Ala Glu Thr Glu Pro Val Glu Gln Asp Ser Ser Gln
            820                 825                 830         
Pro Ser Leu Pro Leu Val Arg Ala Asp Asp Pro Leu Arg Leu Asp Gln
        835                 840                 845             
Glu Leu Gln Gln Pro Gln Thr Gln Glu Lys Thr Ser Asn Ser Leu Thr
    850                 855                 860                 
Glu Asp Ser Lys Met Ala Asn Ala Lys Gln Leu Ser Ser Asp Ala Glu
865                 870                 875                 880 
Ala Gln Lys Leu Gly Lys Pro Ser Ala His Ala Ser Gln Ser Phe Cys
                885                 890                 895     
Glu Ser Ser Ser Glu Thr Pro Phe His Phe Thr Leu Pro Lys Glu Gly
            900                 905                 910         
Asp Ile Ile Pro Pro Leu Thr Gly Ala Thr Pro Pro Leu Ile Gly His
        915                 920                 925             
Leu Lys Leu Glu Pro Lys Arg His Ser Thr Pro Ile Gly Ile Ser Asn
    930                 935                 940                 
Tyr Pro Glu Ser Thr Ile Ala Thr Ser Asp Val Met Ser Glu Ser Met
945                 950                 955                 960 
Val Glu Thr His Asp Pro Ile Leu Gly Ser Gly Lys Gly Asp Ser Gly
                965                 970                 975     
Ala Ala Pro Asp Val Asp Asp Lys Leu Cys Leu Arg Met Lys Leu Val
            980                 985                 990         
Ser Pro Glu Thr Glu Ala Ser Glu Glu Ser Leu Gln Phe Asn Leu Glu
        995                 1000                1005            
Lys Pro Ala Thr Gly Glu Arg Lys Asn Gly Ser Thr Ala Val Ala Glu
    1010                1015                1020                
Ser Val Ala Ser Pro Gln Lys Thr Met Ser Val Leu Ser Cys Ile Cys
1025                1030                1035                1040
Glu Ala Arg Gln Glu Asn Glu Ala Arg Ser Glu Asp Pro Pro Thr Thr
                1045                1050                1055    
Pro Ile Arg Gly Asn Leu Leu His Phe Pro Ser Ser Gln Gly Glu Glu
            1060                1065                1070        
Glu Lys Glu Lys Leu Glu Gly Asp His Thr Ile Arg Gln Ser Gln Gln
        1075                1080                1085            
Pro Met Lys Pro Ile Ser Pro Val Lys Asp Pro Val Ser Pro Ala Ser
    1090                1095                1100                
Gln Lys Met Val Ile Gln Gly Pro Ser Ser Pro Gln Gly Glu Ala Met
1105                1110                1115                1120
Val Thr Asp Val Leu Glu Asp Gln Lys Glu Gly Arg Ser Thr Asn Lys
                1125                1130                1135    
Glu Asn Pro Ser Lys Ala Leu Ile Glu Arg Pro Ser Gln Asn Asn Ile
            1140                1145                1150        
Gly Ile Gln Thr Met Glu Cys Ser Leu Arg Val Pro Glu Thr Val Ser
        1155                1160                1165            
Ala Ala Thr Gln Thr Ile Lys Asn Val Cys Glu Gln Gly Thr Ser Thr
    1170                1175                1180                
Val Asp Gln Asn Phe Gly Lys Gln Asp Ala Thr Val Gln Thr Glu Arg
1185                1190                1195                1200
Gly Ser Gly Glu Lys Pro Val Ser Ala Pro Gly Asp Asp Thr Glu Ser
                1205                1210                1215    
Leu His Ser Gln Gly Glu Glu Glu Phe Asp Met Pro Gln Pro Pro His
            1220                1225                1230        
Gly His Val Leu His Arg His Met Arg Thr Ile Arg Glu Val Arg Thr
        1235                1240                1245            
Leu Val Thr Arg Val Ile Thr Asp Val Tyr Tyr Val Asp Gly Thr Glu
    1250                1255                1260                
Val Glu Arg Lys Val Thr Glu Glu Thr Glu Glu Pro Ile Val Glu Cys
1265                1270                1275                1280
Gln Glu Cys Glu Thr Glu Val Ser Pro Ser Gln Thr Gly Gly Ser Ser
                1285                1290                1295    
Gly Asp Leu Gly Asp Ile Ser Ser Phe Ser Ser Lys Ala Ser Ser Leu
            1300                1305                1310        
His Arg Thr Ser Ser Gly Thr Ser Leu Ser Ala Met His Ser Ser Gly
        1315                1320                1325            
Ser Ser Gly Lys Gly Ala Gly Pro Leu Arg Gly Lys Thr Ser Gly Thr
    1330                1335                1340                
Glu Pro Ala Asp Phe Ala Leu Pro Ser Ser Arg Gly Gly Pro Gly Lys
1345                1350                1355                1360
Leu Ser Pro Arg Lys Gly Val Ser Gln Thr Gly Thr Pro Val Cys Glu
                1365                1370                1375    
Glu Asp Gly Asp Ala Gly Leu Gly Ile Arg Gln Gly Gly Lys Ala Pro
            1380                1385                1390        
Val Thr Pro Arg Gly Arg Gly Arg Arg Gly Arg Pro Pro Ser Arg Thr
        1395                1400                1405            
Thr Gly Thr Arg Glu Thr Ala Val Pro Gly Pro Leu Gly Ile Glu Asp
    1410                1415                1420                
Ile Ser Pro Asn Leu Ser Pro Asp Asp Lys Ser Phe Ser Arg Val Val
1425                1430                1435                1440
Pro Arg Val Pro Asp Ser Thr Arg Arg Thr Asp Val Gly Ala Gly Ala
                1445                1450                1455    
Leu Arg Arg Ser Asp Ser Pro Glu Ile Pro Phe Gln Ala Ala Ala Gly
            1460                1465                1470        
Pro Ser Asp Gly Leu Asp Ala Ser Ser Pro Gly Asn Ser Phe Val Gly
        1475                1480                1485            
Leu Arg Val Val Ala Lys Trp Ser Ser Asn Gly Tyr Phe Tyr Ser Gly
    1490                1495                1500                
Lys Ile Thr Arg Asp Val Gly Ala Gly Lys Tyr Lys Leu Leu Phe Asp
1505                1510                1515                1520
Asp Gly Tyr Glu Cys Asp Val Leu Gly Lys Asp Ile Leu Leu Cys Asp
                1525                1530                1535    
Pro Ile Pro Leu Asp Thr Glu Val Thr Ala Leu Ser Glu Asp Glu Tyr
            1540                1545                1550        
Phe Ser Ala Gly Val Val Lys Gly His Arg Lys Glu Ser Gly Glu Leu
        1555                1560                1565            
Tyr Tyr Ser Ile Glu Lys Glu Gly Gln Arg Lys Trp Tyr Lys Arg Met
    1570                1575                1580                
Ala Val Ile Leu Ser Leu Glu Gln Gly Asn Arg Leu Arg Glu Gln Tyr
1585                1590                1595                1600
Gly Leu Gly Pro Tyr Glu Ala Val Thr Pro Leu Thr Lys Ala Ala Asp
                1605                1610                1615    
Ile Ser Leu Asp Asn Leu Val Glu Gly Lys Arg Lys Arg Arg Ser Asn
            1620                1625                1630        
Val Ser Ser Pro Ala Thr Pro Thr Ala Ser Ser Ser Ser Ser Thr Thr
        1635                1640                1645            
Pro Thr Arg Lys Ile Thr Glu Ser Pro Arg Ala Ser Met Gly Val Leu
    1650                1655                1660                
Ser Gly Lys Arg Lys Leu Ile Thr Ser Glu Glu Glu Arg Ser Pro Ala
1665                1670                1675                1680
Lys Arg Gly Arg Lys Ser Ala Thr Val Lys Pro Gly Ala Val Gly Ala
                1685                1690                1695    
Gly Glu Phe Val Ser Pro Cys Glu Ser Gly Asp Asn Thr Gly Glu Pro
            1700                1705                1710        
Ser Ala Leu Glu Glu Gln Arg Gly Pro Leu Pro Leu Asn Lys Thr Leu
        1715                1720                1725            
Phe Leu Gly Tyr Ala Phe Leu Leu Thr Met Ala Thr Thr Ser Asp Lys
    1730                1735                1740                
Leu Ala Ser Arg Ser Lys Leu Pro Asp Gly Pro Thr Gly Ser Ser Glu
1745                1750                1755                1760
Glu Glu Glu Glu Phe Leu Glu Ile Pro Pro Phe Asn Lys Gln Tyr Thr
                1765                1770                1775    
Glu Ser Gln Leu Arg Ala Gly Ala Gly Tyr Ile Leu Glu Asp Phe Asn
            1780                1785                1790        
Glu Ala Gln Cys Asn Thr Ala Tyr Gln Cys Leu Leu Ile Ala Asp Gln
        1795                1800                1805            
His Cys Arg Thr Arg Lys Tyr Phe Leu Cys Leu Ala Ser Gly Ile Pro
    1810                1815                1820                
Cys Val Ser His Val Trp Val His Asp Ser Cys His Ala Asn Gln Leu
1825                1830                1835                1840
Gln Asn Tyr Arg Asn Tyr Leu Leu Pro Ala Gly Tyr Ser Leu Glu Glu
                1845                1850                1855    
Gln Arg Ile Leu Asp Trp Gln Pro Arg Glu Asn Pro Phe Gln Asn Leu
            1860                1865                1870        
Lys Val Leu Leu Val Ser Asp Gln Gln Gln Asn Phe Leu Glu Leu Trp
        1875                1880                1885            
Ser Glu Ile Leu Met Thr Gly Gly Ala Ala Ser Val Lys Gln His His
    1890                1895                1900                
Ser Ser Ala His Asn Lys Asp Ile Ala Leu Gly Val Phe Asp Val Val
1905                1910                1915                1920
Val Thr Asp Pro Ser Cys Pro Ala Ser Val Leu Lys Cys Ala Glu Ala
                1925                1930                1935    
Leu Gln Leu Pro Val Val Ser Gln Glu Trp Val Ile Gln Cys Leu Ile
            1940                1945                1950        
Val Gly Glu Arg Ile Gly Phe Lys Gln His Pro Lys Tyr Lys His Asp
        1955                1960                1965            
Tyr Val Ser His
    1970        


<210> 7258
<211> 1043
<212> PRT
<213> Homo sapiens

<400> 7258
Met Asp Lys Gly Arg Ala Ala Lys Val Cys His His Ala Asp Cys Gln
 1               5                  10                  15      
Gln Leu His Arg Arg Gly Pro Leu Asn Leu Cys Glu Ala Cys Asp Ser
            20                  25                  30          
Lys Phe His Ser Thr Met His Tyr Asp Gly His Val Arg Phe Asp Leu
        35                  40                  45              
Pro Pro Gln Gly Ser Val Leu Ala Arg Asn Val Ser Thr Arg Ser Cys
    50                  55                  60                  
Pro Pro Arg Thr Ser Pro Ala Val Asp Leu Glu Glu Glu Glu Glu Glu
65                  70                  75                  80  
Ser Ser Val Asp Gly Lys Gly Asp Arg Lys Ser Thr Gly Leu Lys Leu
                85                  90                  95      
Ser Lys Lys Lys Ala Arg Arg Arg His Thr Asp Asp Pro Ser Lys Glu
            100                 105                 110         
Cys Phe Thr Leu Lys Phe Asp Leu Asn Val Asp Ile Glu Thr Glu Ile
        115                 120                 125             
Val Pro Ala Met Lys Lys Lys Ser Leu Gly Glu Val Leu Leu Pro Val
    130                 135                 140                 
Phe Glu Arg Lys Gly Ile Ala Leu Gly Lys Val Asp Ile Tyr Leu Asp
145                 150                 155                 160 
Gln Ser Asn Thr Pro Leu Ser Leu Thr Phe Glu Ala Tyr Arg Phe Gly
                165                 170                 175     
Gly His Tyr Leu Arg Val Lys Ala Pro Ala Lys Pro Gly Asp Glu Gly
            180                 185                 190         
Lys Val Glu Gln Gly Met Lys Asp Ser Lys Ser Leu Ser Leu Pro Ile
        195                 200                 205             
Leu Arg Pro Ala Gly Thr Gly Pro Pro Ala Leu Glu Arg Val Asp Ala
    210                 215                 220                 
Gln Ser Arg Arg Glu Ser Leu Asp Ile Leu Ala Pro Gly Arg Arg Arg
225                 230                 235                 240 
Lys Asn Met Ser Glu Phe Leu Gly Glu Ala Ser Ile Pro Gly Gln Glu
                245                 250                 255     
Pro Pro Thr Pro Ser Ser Cys Ser Leu Pro Ser Gly Ser Ser Gly Ser
            260                 265                 270         
Thr Asn Thr Gly Asp Ser Trp Lys Asn Arg Ala Ala Ser Arg Phe Ser
        275                 280                 285             
Gly Phe Phe Ser Ser Gly Pro Ser Thr Ser Ala Phe Gly Arg Glu Val
    290                 295                 300                 
Asp Lys Met Glu Gln Leu Glu Gly Lys Leu His Thr Tyr Ser Leu Phe
305                 310                 315                 320 
Gly Leu Pro Arg Leu Pro Arg Gly Leu Arg Phe Asp His Asp Ser Trp
                325                 330                 335     
Glu Glu Glu Tyr Asp Glu Asp Glu Asp Glu Asp Asn Ala Cys Leu Arg
            340                 345                 350         
Leu Glu Asp Ser Trp Arg Glu Leu Ile Asp Gly His Glu Lys Leu Thr
        355                 360                 365             
Arg Arg Gln Cys His Gln Gln Glu Ala Val Trp Glu Leu Leu His Thr
    370                 375                 380                 
Glu Ala Ser Tyr Ile Arg Lys Leu Arg Val Ile Ile Asn Leu Phe Leu
385                 390                 395                 400 
Cys Cys Leu Leu Asn Leu Gln Glu Ser Gly Leu Leu Cys Glu Val Glu
                405                 410                 415     
Ala Glu Arg Leu Phe Ser Asn Ile Pro Glu Ile Ala Gln Leu His Arg
            420                 425                 430         
Arg Leu Trp Ala Ser Val Met Ala Pro Val Leu Glu Lys Ala Arg Arg
        435                 440                 445             
Thr Arg Ala Leu Leu Gln Pro Gly Asp Phe Leu Lys Gly Phe Lys Met
    450                 455                 460                 
Phe Gly Ser Leu Phe Lys Pro Tyr Ile Arg Tyr Cys Met Glu Glu Glu
465                 470                 475                 480 
Gly Cys Met Glu Tyr Met Arg Gly Leu Leu Arg Asp Asn Asp Leu Phe
                485                 490                 495     
Arg Ala Tyr Ile Thr Trp Ala Glu Lys His Pro Gln Cys Gln Arg Leu
            500                 505                 510         
Lys Leu Ser Asp Met Leu Ala Lys Pro His Gln Arg Leu Thr Lys Tyr
        515                 520                 525             
Pro Leu Leu Leu Lys Ser Val Leu Arg Lys Thr Glu Glu Pro Arg Ala
    530                 535                 540                 
Lys Glu Ala Val Val Ala Met Ile Gly Ser Val Glu Arg Phe Ile His
545                 550                 555                 560 
His Val Asn Ala Cys Met Arg Gln Arg Gln Glu Arg Gln Arg Leu Ala
                565                 570                 575     
Ala Val Val Ser Arg Ile Asp Ala Tyr Glu Val Val Glu Ser Ser Ser
            580                 585                 590         
Asp Glu Val Asp Lys Leu Leu Lys Glu Phe Leu His Leu Asp Leu Thr
        595                 600                 605             
Ala Pro Ile Pro Gly Ala Ser Pro Glu Glu Thr Arg Gln Leu Leu Leu
    610                 615                 620                 
Glu Gly Ser Leu Arg Met Lys Glu Gly Lys Asp Ser Lys Met Asp Val
625                 630                 635                 640 
Tyr Cys Phe Leu Phe Thr Asp Leu Leu Leu Val Thr Lys Ala Val Lys
                645                 650                 655     
Lys Ala Glu Arg Thr Arg Val Ile Arg Pro Pro Leu Leu Val Asp Lys
            660                 665                 670         
Ile Val Cys Arg Glu Leu Arg Asp Pro Gly Ser Phe Leu Leu Ile Tyr
        675                 680                 685             
Leu Asn Glu Phe His Ser Ala Val Gly Ala Tyr Thr Phe Gln Ala Ser
    690                 695                 700                 
Gly Gln Ala Leu Cys Arg Gly Trp Val Asp Thr Ile Tyr Asn Ala Gln
705                 710                 715                 720 
Asn Gln Leu Gln Gln Leu Arg Ala Gln Glu Pro Pro Gly Ser Gln Gln
                725                 730                 735     
Pro Leu Gln Ser Leu Glu Glu Glu Glu Asp Glu Gln Glu Glu Glu Glu
            740                 745                 750         
Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu Asp Ser Gly Thr Ser Ala
        755                 760                 765             
Ala Ser Ser Pro Thr Ile Met Arg Lys Ser Ser Gly Ser Pro Asp Ser
    770                 775                 780                 
Gln His Cys Ala Ser Asp Gly Ser Thr Glu Thr Leu Ala Met Val Val
785                 790                 795                 800 
Val Glu Pro Gly Asp Thr Leu Ser Ser Pro Glu Phe Asp Ser Gly Pro
                805                 810                 815     
Phe Ser Ser Gln Ser Asp Glu Thr Ser Leu Ser Thr Thr Ala Ser Ser
            820                 825                 830         
Ala Thr Pro Thr Ser Glu Leu Leu Pro Leu Gly Pro Val Asp Gly Arg
        835                 840                 845             
Ser Cys Ser Met Asp Ser Ala Tyr Gly Thr Leu Ser Pro Thr Ser Leu
    850                 855                 860                 
Gln Asp Phe Val Ala Pro Gly Pro Met Ala Glu Leu Val Pro Arg Ala
865                 870                 875                 880 
Pro Glu Ser Pro Arg Val Pro Ser Pro Pro Pro Ser Pro Arg Leu Arg
                885                 890                 895     
Arg Arg Thr Pro Val Gln Leu Leu Ser Cys Pro Pro His Leu Leu Lys
            900                 905                 910         
Ser Lys Ser Glu Ala Ser Leu Leu Gln Leu Leu Ala Gly Ala Gly Thr
        915                 920                 925             
His Gly Thr Pro Ser Ala Pro Ser Arg Ser Leu Ser Glu Leu Cys Leu
    930                 935                 940                 
Ala Val Pro Ala Pro Gly Ile Arg Thr Gln Gly Ser Pro Gln Glu Ala
945                 950                 955                 960 
Gly Pro Ser Trp Asp Cys Arg Gly Ala Pro Ser Pro Gly Ser Gly Pro
                965                 970                 975     
Gly Leu Val Gly Cys Leu Ala Gly Glu Pro Ala Gly Ser His Arg Lys
            980                 985                 990         
Arg Cys Gly Asp Leu Pro Ser Gly Ala Ser Pro Arg Val Gln Pro Glu
        995                 1000                1005            
Pro Pro Pro Gly Val Ser Ala Gln His Arg Lys Leu Thr Leu Ala Gln
    1010                1015                1020                
Leu Tyr Arg Ile Arg Thr Thr Leu Leu Leu Asn Ser Thr Leu Thr Ala
1025                1030                1035                1040
Ser Glu Val
            


<210> 7259
<211> 729
<212> PRT
<213> Homo sapiens

<400> 7259
Met Asn Ser Val Leu Thr Lys His Gly Ser Pro Pro Arg Ser Trp Leu
 1               5                  10                  15      
Ser Leu Cys Ser Gly Thr Asp Asp Gln Ser Pro Ala Glu Lys Lys Gly
            20                  25                  30          
Leu Arg Cys Gln Asn Pro Ala Cys Met Asp Lys Gly Arg Ala Ala Lys
        35                  40                  45              
Val Cys His His Ala Asp Cys Gln Gln Leu His Arg Arg Gly Pro Leu
    50                  55                  60                  
Asn Leu Cys Glu Ala Cys Asp Ser Lys Phe His Ser Thr Met His Tyr
65                  70                  75                  80  
Asp Gly His Val Arg Phe Asp Leu Pro Pro Gln Gly Ser Val Leu Ala
                85                  90                  95      
Arg Asn Val Ser Thr Arg Ser Cys Pro Pro Arg Thr Ser Pro Ala Val
            100                 105                 110         
Asp Leu Glu Glu Glu Glu Glu Glu Ser Ser Val Asp Gly Lys Gly Asp
        115                 120                 125             
Arg Lys Ser Thr Gly Leu Lys Leu Ser Lys Lys Lys Ala Arg Arg Arg
    130                 135                 140                 
His Thr Asp Asp Pro Ser Lys Glu Cys Phe Thr Leu Lys Phe Asp Leu
145                 150                 155                 160 
Asn Val Asp Ile Glu Thr Glu Ile Val Pro Ala Met Lys Lys Lys Ser
                165                 170                 175     
Leu Gly Glu Val Leu Leu Pro Val Phe Glu Arg Lys Gly Ile Ala Leu
            180                 185                 190         
Gly Lys Val Asp Ile Tyr Leu Asp Gln Ser Asn Thr Pro Leu Ser Leu
        195                 200                 205             
Thr Phe Glu Ala Tyr Arg Phe Gly Gly His Tyr Leu Arg Val Lys Ala
    210                 215                 220                 
Pro Ala Lys Pro Gly Asp Glu Gly Lys Val Glu Gln Gly Met Lys Asp
225                 230                 235                 240 
Ser Lys Ser Leu Ser Leu Pro Ile Leu Arg Pro Ala Gly Thr Gly Pro
                245                 250                 255     
Pro Ala Leu Glu Arg Val Asp Ala Gln Ser Arg Arg Glu Ser Leu Asp
            260                 265                 270         
Ile Leu Ala Pro Gly Arg Arg Arg Lys Asn Met Ser Glu Phe Leu Gly
        275                 280                 285             
Glu Ala Ser Ile Pro Gly Gln Glu Pro Pro Thr Pro Ser Ser Cys Ser
    290                 295                 300                 
Leu Pro Ser Gly Ser Ser Gly Ser Thr Asn Thr Gly Asp Ser Trp Lys
305                 310                 315                 320 
Asn Arg Ala Ala Ser Arg Phe Ser Gly Phe Phe Ser Ser Gly Pro Ser
                325                 330                 335     
Thr Ser Ala Phe Gly Arg Glu Val Asp Lys Met Glu Gln Leu Glu Gly
            340                 345                 350         
Lys Leu His Thr Tyr Ser Leu Phe Gly Leu Pro Arg Leu Pro Arg Gly
        355                 360                 365             
Leu Arg Phe Asp His Asp Ser Trp Glu Glu Glu Tyr Asp Glu Asp Glu
    370                 375                 380                 
Asp Glu Asp Asn Ala Cys Leu Arg Leu Glu Asp Ser Trp Arg Glu Leu
385                 390                 395                 400 
Ile Asp Gly His Glu Lys Leu Thr Arg Arg Gln Cys His Gln Gln Glu
                405                 410                 415     
Ala Val Trp Glu Leu Leu His Thr Glu Ala Ser Tyr Ile Arg Lys Leu
            420                 425                 430         
Arg Val Ile Ile Asn Leu Phe Leu Cys Cys Leu Leu Asn Leu Gln Glu
        435                 440                 445             
Ser Gly Leu Leu Cys Glu Val Glu Ala Glu Arg Leu Phe Ser Asn Ile
    450                 455                 460                 
Pro Glu Ile Ala Gln Leu His Arg Arg Leu Trp Ala Ser Val Met Ala
465                 470                 475                 480 
Pro Val Leu Glu Lys Ala Arg Arg Thr Arg Ala Leu Leu Gln Pro Gly
                485                 490                 495     
Asp Phe Leu Lys Gly Phe Lys Met Phe Gly Ser Leu Phe Lys Pro Tyr
            500                 505                 510         
Ile Arg Tyr Cys Met Glu Glu Glu Gly Cys Met Glu Tyr Met Arg Gly
        515                 520                 525             
Leu Leu Arg Asp Asn Asp Leu Phe Arg Ala Tyr Ile Thr Trp Ala Glu
    530                 535                 540                 
Lys His Pro Gln Cys Gln Arg Leu Lys Leu Ser Asp Met Leu Ala Lys
545                 550                 555                 560 
Pro His Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu Lys Ser Val Leu
                565                 570                 575     
Arg Lys Thr Glu Glu Pro Arg Ala Lys Glu Ala Val Val Ala Asn Arg
            580                 585                 590         
Leu Arg Gly Ala Leu His Pro Pro Arg Glu Arg Val His Ala Ala Ala
        595                 600                 605             
Ala Gly Ala Ala Ala Ala Gly Gly Arg Gly Glu Pro His Arg Arg Leu
    610                 615                 620                 
Arg Gly Gly Gly Lys Gln Gln Arg Arg Ser Gly Gln Ala Pro Glu Gly
625                 630                 635                 640 
Ile Ser Ala Pro Gly Leu Asp Ser Ala His Pro Trp Arg Leu Pro Gly
                645                 650                 655     
Gly Asp Ala Ala Ala Ala Ala Gly Gly Glu Pro Glu Asp Glu Gly Gly
            660                 665                 670         
Glu Gly Gln Gln Asp Gly Cys Val Leu Leu Pro Leu His Gly Ser Ala
        675                 680                 685             
Val Gly Asp Gln Ser Ser Glu Glu Gly Arg Glu Asp Gln Gly His Gln
    690                 695                 700                 
Ala Thr Pro Ala Arg Gly Gln Asp Cys Val Pro Gly Ala Thr Gly Pro
705                 710                 715                 720 
Trp Val Leu Pro Pro Tyr Leu Pro Glu
                725                 


<210> 7260
<211> 141
<212> PRT
<213> Homo sapiens

<400> 7260
Lys Arg Arg Arg Ile Asn Ser Ser Val Thr Thr Glu Thr Ile Ser Glu
 1               5                  10                  15      
Thr Thr Glu Val Leu Asn Glu Pro Phe Asp Asn Ser Asp Glu Glu Arg
            20                  25                  30          
Pro Met Pro Gln Leu Glu Pro Thr Cys Glu Ile Glu Val Glu Glu Asp
        35                  40                  45              
Gly Arg Lys Pro Val Leu Arg Lys Ala Phe Gln His Gln Pro Gly Lys
    50                  55                  60                  
Lys Arg Gln Thr Glu Glu Glu Glu Gly Lys Asp Asn His Cys Phe Lys
65                  70                  75                  80  
Asn Ala Asp Pro Cys Arg Asn Phe Gly Ser Leu Phe Asp Leu Glu Asn
                85                  90                  95      
Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly Gly Glu Leu Gly Leu Leu
            100                 105                 110         
Asn Ser Gly Asn Leu Val Pro Asp Ala Ala Ser Lys His Lys Gln Leu
        115                 120                 125             
Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser Ser Ile Asn
    130                 135                 140     


<210> 7261
<211> 864
<212> PRT
<213> Homo sapiens

<400> 7261
Met Gly Asn Arg Gly Met Glu Asp Leu Ile Pro Leu Val Asn Arg Leu
 1               5                  10                  15      
Gln Asp Ala Phe Ser Ala Ile Gly Gln Asn Ala Asp Leu Asp Leu Pro
            20                  25                  30          
Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu
        35                  40                  45              
Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val
    50                  55                  60                  
Thr Arg Arg Pro Leu Val Leu Gln Leu Val Asn Ala Thr Thr Glu Tyr
65                  70                  75                  80  
Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Glu Glu
                85                  90                  95      
Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn
            100                 105                 110         
Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His
        115                 120                 125             
Val Leu Asn Leu Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro
    130                 135                 140                 
Val Gly Asp Gln Pro Pro Asp Ile Glu Phe Gln Ile Arg Asp Met Leu
145                 150                 155                 160 
Met Gln Phe Val Thr Lys Glu Asn Cys Leu Ile Leu Ala Val Ser Pro
                165                 170                 175     
Ala Asn Ser Asp Leu Ala Asn Ser Asp Ala Leu Lys Val Ala Lys Glu
            180                 185                 190         
Val Asp Pro Gln Gly Gln Arg Thr Ile Gly Val Ile Thr Lys Leu Asp
        195                 200                 205             
Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu
    210                 215                 220                 
Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys
225                 230                 235                 240 
Asp Ile Asp Gly Lys Lys Asp Ile Thr Ala Ala Leu Ala Ala Glu Arg
                245                 250                 255     
Lys Phe Phe Leu Ser His Pro Ser Tyr Arg His Leu Ala Asp Arg Met
            260                 265                 270         
Gly Thr Pro Tyr Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His
        275                 280                 285             
Ile Arg Asp Thr Leu Pro Gly Leu Arg Asn Lys Leu Gln Ser Gln Leu
    290                 295                 300                 
Leu Ser Ile Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp
305                 310                 315                 320 
Asp Pro Ala Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe
                325                 330                 335     
Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Ile Asp
            340                 345                 350         
Thr Tyr Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu
        355                 360                 365             
Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Glu Leu
    370                 375                 380                 
Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr
385                 390                 395                 400 
Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Thr Ile Val Lys Lys Gln
                405                 410                 415     
Val Lys Lys Ile Arg Glu Pro Cys Leu Lys Cys Val Asp Met Val Ile
            420                 425                 430         
Ser Glu Leu Ile Ser Thr Val Arg Gln Cys Thr Lys Lys Leu Gln Gln
        435                 440                 445             
Tyr Pro Arg Leu Arg Glu Glu Met Glu Arg Ile Val Thr Thr His Ile
    450                 455                 460                 
Arg Glu Arg Glu Gly Arg Thr Lys Glu Gln Val Met Leu Leu Ile Asp
465                 470                 475                 480 
Ile Glu Leu Ala Tyr Met Asn Thr Asn His Glu Asp Phe Ile Gly Phe
                485                 490                 495     
Ala Asn Ala Gln Gln Arg Ser Asn Gln Met Asn Lys Lys Lys Thr Ser
            500                 505                 510         
Gly Asn Gln Asp Glu Ile Leu Val Ile Arg Lys Gly Trp Leu Thr Ile
        515                 520                 525             
Asn Asn Ile Gly Ile Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val
    530                 535                 540                 
Leu Thr Ala Glu Asn Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu
545                 550                 555                 560 
Lys Lys Tyr Met Leu Ser Val Asp Asn Leu Lys Leu Arg Asp Val Glu
                565                 570                 575     
Lys Gly Phe Met Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu
            580                 585                 590         
Gln Arg Asn Val Tyr Lys Asp Tyr Arg Gln Leu Glu Leu Ala Cys Glu
        595                 600                 605             
Thr Gln Glu Glu Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly
    610                 615                 620                 
Val Tyr Pro Glu Arg Val Gly Asp Lys Glu Lys Ala Ser Glu Thr Glu
625                 630                 635                 640 
Glu Asn Gly Ser Asp Ser Phe Met His Ser Met Asp Pro Gln Leu Glu
                645                 650                 655     
Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser Tyr Met Ala Ile
            660                 665                 670         
Val Asn Lys Thr Val Arg Asp Leu Met Pro Lys Thr Ile Met His Leu
        675                 680                 685             
Met Ile Asn Asn Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ala Asn
    690                 695                 700                 
Leu Tyr Ser Cys Gly Asp Gln Asn Thr Leu Met Glu Glu Ser Ala Glu
705                 710                 715                 720 
Gln Ala Gln Arg Arg Asp Glu Met Leu Arg Met Tyr His Ala Leu Lys
                725                 730                 735     
Glu Ala Leu Ser Ile Ile Gly Asn Ile Asn Thr Thr Thr Val Ser Thr
            740                 745                 750         
Pro Met Pro Pro Pro Val Asp Asp Ser Trp Leu Gln Val Gln Ser Val
        755                 760                 765             
Pro Ala Gly Arg Arg Ser Pro Thr Ser Ser Pro Thr Pro Gln Arg Arg
    770                 775                 780                 
Ala Pro Ala Val Pro Pro Ala Arg Pro Gly Ser Arg Gly Pro Ala Pro
785                 790                 795                 800 
Gly Pro Pro Pro Ala Gly Ser Ala Leu Gly Gly Ala Pro Pro Val Pro
                805                 810                 815     
Ser Arg Pro Gly Ala Ser Pro Asp Pro Phe Gly Pro Pro Pro Gln Val
            820                 825                 830         
Pro Ser Arg Pro Asn Arg Ala Pro Pro Gly Val Pro Ser Arg Ser Gly
        835                 840                 845             
Gln Ala Ser Pro Ser Arg Pro Glu Ser Pro Arg Pro Pro Phe Asp Leu
    850                 855                 860                 


<210> 7262
<211> 1662
<212> PRT
<213> Homo sapiens

<400> 7262
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His
 1               5                  10                  15      
Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile
            20                  25                  30          
Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg
        35                  40                  45              
Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro
    50                  55                  60                  
Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala
65                  70                  75                  80  
Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln
                85                  90                  95      
Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu
            100                 105                 110         
His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met
        115                 120                 125             
Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln
    130                 135                 140                 
Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp
145                 150                 155                 160 
Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys
                165                 170                 175     
Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu
            180                 185                 190         
Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu
        195                 200                 205             
His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala
    210                 215                 220                 
Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu
225                 230                 235                 240 
Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val
                245                 250                 255     
Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser
            260                 265                 270         
Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly
        275                 280                 285             
Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln
    290                 295                 300                 
Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr
305                 310                 315                 320 
Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe
                325                 330                 335     
Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala
            340                 345                 350         
Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr
        355                 360                 365             
Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser
    370                 375                 380                 
Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp
385                 390                 395                 400 
Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln
                405                 410                 415     
Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser
            420                 425                 430         
Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro
        435                 440                 445             
Glu Phe Asn Val Arg Lys Val Glu Ala Lys Leu Pro Ala Lys Pro Leu
    450                 455                 460                 
Phe Val Asp Pro Asp Thr Ser Gly Val His Glu His Trp His Thr Arg
465                 470                 475                 480 
Phe Pro Ala Arg Glu Gly Gln Glu Ile Gln Arg Glu Glu Gln Thr Gln
                485                 490                 495     
Gln Glu Gly Ser Ala Cys Val Pro Val Ile Ser Val Glu Val Pro Thr
            500                 505                 510         
His Thr Asp Asn Trp Ile Val Met Ala Thr Ser Gln Asp Glu Pro Ala
        515                 520                 525             
Tyr Gly Lys His Gln Val Leu Gly Ser Thr Leu Tyr Ile Arg His Arg
    530                 535                 540                 
Lys Pro Ser Asp Gly Ala His Leu Ala His Glu Lys Thr Arg Glu Arg
545                 550                 555                 560 
Asn Gly Ala Lys Val Asp Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly
                565                 570                 575     
Glu Trp Gln Phe Asn His Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp
            580                 585                 590         
Ala Ala Phe Ala Glu Ile Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro
        595                 600                 605             
Leu Ser Cys Glu Thr Arg Val Asp Leu Cys Asp Asp Leu Ala Pro Val
    610                 615                 620                 
Ala Arg Gln Leu Ala Pro Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg
625                 630                 635                 640 
Pro Ala Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr
                645                 650                 655     
Val Asn Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn
            660                 665                 670         
Tyr Met Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly
        675                 680                 685             
Cys Met Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn
    690                 695                 700                 
Pro Gly His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His
705                 710                 715                 720 
Arg Gly Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp
                725                 730                 735     
Ala Met Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His
            740                 745                 750         
Ser Lys Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg
        755                 760                 765             
Ser Gln Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp
    770                 775                 780                 
Pro Tyr Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln
785                 790                 795                 800 
Gln Ala Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn
                805                 810                 815     
Ala Tyr His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr
            820                 825                 830         
Leu Thr Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg
        835                 840                 845             
Phe Ser Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro
    850                 855                 860                 
Glu Cys Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro
865                 870                 875                 880 
Leu Val Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys
                885                 890                 895     
His Asn Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp
            900                 905                 910         
Tyr Lys Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val
        915                 920                 925             
Leu Ser Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp
    930                 935                 940                 
Glu Arg His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu
945                 950                 955                 960 
Gly Ala Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg
                965                 970                 975     
Asp His Pro Cys Leu Gln Ala Pro Glu Leu Asp Glu His Leu Val Glu
            980                 985                 990         
Arg Ala Thr Gln Glu Ser Thr Leu Asp His Trp Lys Phe Leu Gln Glu
        995                 1000                1005            
Gln Asn Lys Thr Lys Pro Glu Phe Asn Val Arg Lys Val Glu Ala Lys
    1010                1015                1020                
Leu Pro Ala Lys Pro Leu Phe Val Asp Pro Asp Thr Ser Gly Val His
1025                1030                1035                1040
Glu His Trp His Thr Arg Phe Pro Ala Arg Glu Gly Gln Glu Ile Gln
                1045                1050                1055    
Arg Glu Glu Gln Thr Gln Gln Glu Gly Ser Ala Cys Val Pro Val Ile
            1060                1065                1070        
Ser Val Glu Val Pro Thr His Thr Asp Asn Trp Ile Val Met Ala Thr
        1075                1080                1085            
Ser Gln Asp Glu Pro Ala Tyr Gly Lys His Gln Val Leu Gly Ser Thr
    1090                1095                1100                
Leu Tyr Ile Arg His Arg Lys Pro Ser Asp Gly Ala His Leu Ala His
1105                1110                1115                1120
Glu Lys Thr Arg Glu Arg Asn Gly Ala Lys Val Asp Met Glu Asp Asp
                1125                1130                1135    
Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His Phe Ser Lys Leu
            1140                1145                1150        
Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile Gln Arg Thr Ser
        1155                1160                1165            
Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg Val Asp Leu Cys
    1170                1175                1180                
Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro Arg Glu Lys Leu
1185                1190                1195                1200
Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala Gly Leu Gln Asn
                1205                1210                1215    
Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln Cys Leu Thr Tyr
            1220                1225                1230        
Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu His Ser Gln Thr
        1235                1240                1245            
Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met Gln Ala His Ile
    1250                1255                1260                
Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln Pro Ser Gln Ala
1265                1270                1275                1280
Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp Ala His Glu Phe
                1285                1290                1295    
Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys Leu Pro Gly His
            1300                1305                1310        
Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu Ile His Gln Ile
        1315                1320                1325            
Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu His Cys His Gly
    1330                1335                1340                
Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala Leu Asp Ile Gln
1345                1350                1355                1360
Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu Ala Lys Pro Glu
                1365                1370                1375    
Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val Cys Leu Gln Arg
            1380                1385                1390        
Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser Ala Lys Val Leu
        1395                1400                1405            
Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly Asn Lys Ile Ala
    1410                1415                1420                
Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln Pro Tyr Met Ser
1425                1430                1435                1440
Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr Ala Val Leu Val
                1445                1450                1455    
His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe Ser Tyr Val Lys
            1460                1465                1470        
Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala Glu Val Thr Ala
        1475                1480                1485            
Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr Val Leu Phe Tyr
    1490                1495                1500                
Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser Val Ser Arg Gly
1505                1510                1515                1520
Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp Arg Arg Ala Thr
                1525                1530                1535    
Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln Ala Pro Glu Leu
            1540                1545                1550        
Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser Thr Leu Asp His
        1555                1560                1565            
Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro Glu Phe Asn Val
    1570                1575                1580                
Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu Val Ile His Gln
1585                1590                1595                1600
Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro Glu Gln Gln Ser
                1605                1610                1615    
Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His Gln Glu Ser Met
            1620                1625                1630        
Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala Arg Arg Ser Lys
        1635                1640                1645            
Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val Cys Gln
    1650                1655                1660        


<210> 7263
<211> 542
<212> PRT
<213> Homo sapiens

<400> 7263
Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg Val Asp Leu
 1               5                  10                  15      
Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro Arg Glu Lys
            20                  25                  30          
Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala Gly Leu Gln
        35                  40                  45              
Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln Cys Leu Thr
    50                  55                  60                  
Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu His Ser Gln
65                  70                  75                  80  
Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met Gln Ala His
                85                  90                  95      
Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln Pro Ser Gln
            100                 105                 110         
Ala Leu Ala Ser Gly Phe His Arg Gly Lys Gln Glu Asp Val His Glu
        115                 120                 125             
Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys Leu Pro Gly
    130                 135                 140                 
His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu Ile His Gln
145                 150                 155                 160 
Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu His Cys His
                165                 170                 175     
Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala Leu Asp Ile
            180                 185                 190         
Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu Val Lys Pro
        195                 200                 205             
Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu Cys Leu Gln
    210                 215                 220                 
Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser Ala Lys Val
225                 230                 235                 240 
Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly Asn Lys Leu
                245                 250                 255     
Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln Pro Tyr Met
            260                 265                 270         
Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr Ala Val Leu
        275                 280                 285             
Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe Ser Tyr Val
    290                 295                 300                 
Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala Glu Val Thr
305                 310                 315                 320 
Val Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr Val Leu Phe
                325                 330                 335     
Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser Val Ser Arg
            340                 345                 350         
Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp Arg Arg Ala
        355                 360                 365             
Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln Ala Pro Glu
    370                 375                 380                 
Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser Thr Leu Asp
385                 390                 395                 400 
His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro Glu Pro Ala
                405                 410                 415     
Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln Val Pro Glu
            420                 425                 430         
Leu Asp Glu His Leu Val Glu Arg Ala Thr Glu Glu Ser Thr Leu Asp
        435                 440                 445             
His Trp Lys Phe Pro Gln Glu Gln Asn Lys Met Lys Pro Glu Phe Asn
    450                 455                 460                 
Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu Val Ile His
465                 470                 475                 480 
Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro Glu Gln Gln
                485                 490                 495     
Ser Ser Leu Leu Asn Leu Ser Ser Met Asn Ser Thr Asp Gln Glu Ser
            500                 505                 510         
Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr Arg Arg Ser
        515                 520                 525             
Lys Gly Lys Asn Lys His Ser Lys Arg Ser Leu Leu Val Cys
    530                 535                 540         


<210> 7264
<211> 530
<212> PRT
<213> Homo sapiens

<400> 7264
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His
 1               5                  10                  15      
Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile
            20                  25                  30          
Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Ala Arg
        35                  40                  45              
Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro
    50                  55                  60                  
Arg Lys Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala
65                  70                  75                  80  
Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln
                85                  90                  95      
Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu
            100                 105                 110         
His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met
        115                 120                 125             
Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln
    130                 135                 140                 
Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp
145                 150                 155                 160 
Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys
                165                 170                 175     
Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu
            180                 185                 190         
Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu
        195                 200                 205             
His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala
    210                 215                 220                 
Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu
225                 230                 235                 240 
Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu
                245                 250                 255     
Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser
            260                 265                 270         
Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly
        275                 280                 285             
Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln
    290                 295                 300                 
Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr
305                 310                 315                 320 
Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe
                325                 330                 335     
Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala
            340                 345                 350         
Lys Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr
        355                 360                 365             
Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser
    370                 375                 380                 
Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp
385                 390                 395                 400 
Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln
                405                 410                 415     
Ala Pro Glu Leu Asp Glu Arg Leu Val Glu Arg Ala Thr Gln Glu Ser
            420                 425                 430         
Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Thr Lys Pro
        435                 440                 445             
Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu
    450                 455                 460                 
Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro
465                 470                 475                 480 
Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp
                485                 490                 495     
Gln Glu Ser Val Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr
            500                 505                 510         
Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val
        515                 520                 525             
Cys Gln
    530 


<210> 7265
<211> 530
<212> PRT
<213> Homo sapiens

<400> 7265
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His
 1               5                  10                  15      
Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile
            20                  25                  30          
Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg
        35                  40                  45              
Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro
    50                  55                  60                  
Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala
65                  70                  75                  80  
Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln
                85                  90                  95      
Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu
            100                 105                 110         
His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met
        115                 120                 125             
Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln
    130                 135                 140                 
Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp
145                 150                 155                 160 
Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys
                165                 170                 175     
Leu Pro Gly His Lys Gln Val Asp His His Cys Lys Asp Thr Thr Leu
            180                 185                 190         
Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu
        195                 200                 205             
His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala
    210                 215                 220                 
Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu
225                 230                 235                 240 
Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu
                245                 250                 255     
Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser
            260                 265                 270         
Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly
        275                 280                 285             
Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln
    290                 295                 300                 
Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr
305                 310                 315                 320 
Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe
                325                 330                 335     
Ser Tyr Val Lys Ala Gln Glu Val Gln Trp Tyr Lys Met Asp Asp Ala
            340                 345                 350         
Glu Val Thr Val Cys Ser Ile Ile Ser Val Leu Ser Gln Gln Ala Tyr
        355                 360                 365             
Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser
    370                 375                 380                 
Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp
385                 390                 395                 400 
Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln
                405                 410                 415     
Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser
            420                 425                 430         
Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro
        435                 440                 445             
Glu Phe Asn Val Gly Lys Val Glu Gly Thr Leu Pro Pro Asn Ala Leu
    450                 455                 460                 
Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro
465                 470                 475                 480 
Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp
                485                 490                 495     
Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr
            500                 505                 510         
Arg Arg Ala Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val
        515                 520                 525             
Cys Gln
    530 


<210> 7266
<211> 134
<212> PRT
<213> Homo sapiens

<400> 7266
Met Thr Pro Leu Pro Tyr Arg Ser Arg Val Lys Pro Arg Ser Pro Thr
 1               5                  10                  15      
Asn Thr His Ala His Leu Glu Leu Thr Leu Val Lys Cys Ser Lys Lys
            20                  25                  30          
Asp Val Gly Trp Ser Leu Gly Ile Ile Pro Trp Ser Ser Gly Tyr Pro
        35                  40                  45              
Arg Pro Leu Ser Ser His Ser Ser Pro Glu His Ile Pro Leu Glu Lys
    50                  55                  60                  
Leu Cys Thr Cys Ala Gln Ala Pro Ala Ala Gly Val Pro Ser Thr Ala
65                  70                  75                  80  
Gln Leu Phe Met Lys Asn Arg Asn Gln Pro Lys His Leu Tyr Glu Glu
                85                  90                  95      
Lys Arg Arg Asn Ala Glu Trp His Val His Met Met Glu Tyr Tyr Ala
            100                 105                 110         
Ala Glu Asn Met Asn Asn Trp Ser His Gly Met Asn Glu Ala Glu Arg
        115                 120                 125             
Phe Glu Ala Ser Thr Lys
    130                 


<210> 7267
<211> 730
<212> PRT
<213> Homo sapiens

<400> 7267
Met Ser Lys Asn Ser Glu Phe Ile Asn Leu Ser Phe Leu Leu Asp His
 1               5                  10                  15      
Glu Lys Glu Met Ile Leu Gly Val Leu Lys Arg Asp Glu Tyr Leu Lys
            20                  25                  30          
Lys Val Glu Asp Lys Arg Ile Arg Lys Leu Lys Asn Glu Leu Leu Glu
        35                  40                  45              
Ala Lys Arg Arg Ser Gly Lys Thr Gln Gln Glu Ala Ser Arg Val Cys
    50                  55                  60                  
Val His Cys His Arg Asn Leu Gly Leu Ile Phe Asp Arg Gly Asp Pro
65                  70                  75                  80  
Cys Gln Ala Cys Ser Leu Arg Val Cys Arg Glu Cys Arg Val Ala Gly
                85                  90                  95      
Pro Asn Gly Ser Trp Lys Cys Thr Val Cys Asp Lys Ile Ala Gln Leu
            100                 105                 110         
Arg Ile Ile Thr Gly Glu Trp Phe Phe Glu Glu Lys Ala Lys Arg Phe
        115                 120                 125             
Lys Gln Val Asn Val Leu Gly Thr Asp Val Val Arg Gln Ser Ile Leu
    130                 135                 140                 
Arg Arg Ser Pro Gly Ala Glu Glu Val Gln Ser Gln Glu Gln Thr Arg
145                 150                 155                 160 
Gln Asp Ala Glu Lys Ser Asp Thr Ser Pro Val Ala Gly Lys Lys Ala
                165                 170                 175     
Ser His Asp Gly Pro Lys Arg Lys Gly Phe Leu Leu Ser Lys Phe Arg
            180                 185                 190         
Ser Ala Thr Arg Gly Glu Ile Ile Thr Pro Lys Thr Asp Thr Gly Arg
        195                 200                 205             
Ser Tyr Ser Leu Asp Leu Asp Gly Gln His Phe Arg Ser Leu Lys Ser
    210                 215                 220                 
Pro Pro Gly Ser Asp Arg Gly Ser Thr Gly Ser Ser Asp Leu Asn Asp
225                 230                 235                 240 
Gln Glu Pro Gly Pro Arg Thr Pro Lys Ser Ser Arg Ser Asn Gly Val
                245                 250                 255     
Thr Pro Gly Thr Gln Ser Ser Pro Ala Pro Ser Thr Arg Thr Val Thr
            260                 265                 270         
Ser Val Ile Ser Arg Glu Tyr Gly Phe Glu Asn Ser Met Asp Leu Ala
        275                 280                 285             
Ala Ile Glu Gly Thr Ser Gln Glu Leu Thr Lys Ser His Arg Arg Asn
    290                 295                 300                 
Thr Ser Gly Thr Pro Ser Ile Ala Val Ser Gly Thr Ser Leu Ser Ser
305                 310                 315                 320 
Asp Gln Ser Arg Ser Glu Leu Asp Leu Ser Glu Ser Phe Thr Glu Asp
                325                 330                 335     
Ser Glu Asp Thr Val Ser Ile Arg Ser Lys Ser Val Pro Gly Ala Leu
            340                 345                 350         
Asp Lys Asp Ser Leu Glu Glu Thr Glu Glu Ser Ile Asp Ala Leu Val
        355                 360                 365             
Ser Ser Gln Leu Ser Thr Asn Thr His Arg Leu Ala Ser Gly Leu Ser
    370                 375                 380                 
Thr Thr Ser Leu Asn Ser Met Met Ser Val Tyr Ser Glu Thr Gly Asp
385                 390                 395                 400 
Tyr Gly Asn Val Lys Val Ser Gly Glu Ile Leu Leu His Ile Ser Tyr
                405                 410                 415     
Cys Tyr Lys Thr Gly Gly Leu Tyr Ile Phe Val Lys Asn Cys Arg Asn
            420                 425                 430         
Leu Ala Ile Gly Asp Glu Lys Lys Gln Arg Thr Asp Ala Tyr Val Lys
        435                 440                 445             
Ser Tyr Leu Leu Pro Asp Lys Ser Arg Asn Asn Lys Arg Lys Thr Lys
    450                 455                 460                 
Ile Arg Thr Gly Thr Asn Pro Glu Phe Asn Glu Thr Leu Lys Tyr Thr
465                 470                 475                 480 
Ile Ser His Thr Gln Leu Glu Thr Arg Thr Leu Gln Leu Ser Val Trp
                485                 490                 495     
His Tyr Asp Arg Phe Gly Arg Asn Ser Phe Leu Gly Glu Val Glu Ile
            500                 505                 510         
Pro Phe Asp Ser Trp Asn Phe Glu Asn Pro Thr Asp Glu Trp Phe Val
        515                 520                 525             
Leu Gln Pro Lys Val Glu Phe Ala Pro Asp Ile Gly Leu Gln Tyr Lys
    530                 535                 540                 
Gly Glu Leu Thr Val Val Leu Arg Tyr Ile Pro Pro Glu Glu Asn Leu
545                 550                 555                 560 
Met Leu Pro Pro Glu Gln Leu Gln Gly Asn Lys Thr Phe Lys Lys Gly
                565                 570                 575     
Lys Lys Lys Glu Ser Pro Val Ile Ser Gly Gly Ile Leu Glu Val Phe
            580                 585                 590         
Ile Lys Glu Ala Lys Asn Leu Thr Ala Val Lys Ser Gly Gly Thr Ser
        595                 600                 605             
Asp Ser Phe Val Lys Gly Tyr Leu Leu Pro Asp Asp Ser Lys Ala Thr
    610                 615                 620                 
Lys His Lys Thr Leu Val Ile Lys Lys Ser Val Asn Pro Gln Trp Asn
625                 630                 635                 640 
His Thr Phe Met Phe Ser Gly Ile His Pro Gln Asp Ile Lys Asn Val
                645                 650                 655     
Cys Leu Glu Leu Thr Ile Trp Asp Lys Glu Ala Phe Ser Ser Asn Ile
            660                 665                 670         
Phe Leu Gly Gly Val Arg Leu Asn Ser Gly Ser Gly Val Ser His Gly
        675                 680                 685             
Lys Asn Val Asp Trp Met Asp Ser Gln Gly Glu Glu Gln Arg Leu Trp
    690                 695                 700                 
Gln Lys Met Ala Asn Asn Pro Gly Thr Pro Phe Glu Gly Val Leu Met
705                 710                 715                 720 
Leu Arg Ser Ser Met Gly Lys Cys Arg Leu
                725                 730 


<210> 7268
<211> 1048
<212> PRT
<213> Homo sapiens

<400> 7268
Met Ser Asn Lys Thr Gly Gly Lys Arg Pro Ala Thr Thr Asn Ser Asp
 1               5                  10                  15      
Ile Pro Asn His Asn Met Val Ser Glu Val Pro Pro Glu Arg Pro Ser
            20                  25                  30          
Val Arg Ala Thr Arg Thr Ala Arg Lys Ala Ile Ala Phe Gly Lys Arg
        35                  40                  45              
Ser His Ser Met Lys Arg Asn Pro Asn Ala Pro Val Thr Lys Ala Gly
    50                  55                  60                  
Trp Leu Phe Lys Gln Ala Ser Ser Gly Val Lys Gln Trp Asn Lys Arg
65                  70                  75                  80  
Trp Phe Val Leu Val Asp Arg Cys Leu Phe Tyr Tyr Lys Asp Glu Lys
                85                  90                  95      
Glu Glu Ser Ile Leu Gly Ser Ile Pro Leu Leu Ser Phe Arg Val Ala
            100                 105                 110         
Ala Val Gln Pro Ser Asp Asn Ile Ser Arg Lys His Thr Phe Lys Ala
        115                 120                 125             
Glu His Ala Gly Val Arg Thr Tyr Phe Phe Ser Ala Glu Ser Pro Glu
    130                 135                 140                 
Glu Gln Glu Ala Trp Ile Gln Ala Met Gly Glu Ala Ala Arg Val Gln
145                 150                 155                 160 
Ile Pro Pro Ala Gln Lys Ser Val Pro Gln Ala Val Arg His Ser His
                165                 170                 175     
Glu Lys Pro Asp Ser Glu Asn Val Pro Pro Ser Lys His His Gln Gln
            180                 185                 190         
Pro Pro His Asn Ser Leu Pro Lys Pro Glu Pro Glu Ala Lys Thr Arg
        195                 200                 205             
Gly Glu Gly Asp Gly Arg Gly Cys Glu Lys Ala Glu Arg Arg Pro Glu
    210                 215                 220                 
Arg Pro Glu Val Lys Lys Glu Pro Pro Val Lys Ala Asn Gly Leu Pro
225                 230                 235                 240 
Ala Gly Pro Glu Pro Ala Ser Glu Pro Gly Ser Pro Tyr Pro Glu Gly
                245                 250                 255     
Pro Arg Val Pro Gly Gly Gly Glu Gln Pro Ala Gln Pro Asn Gly Trp
            260                 265                 270         
Gln Tyr His Ser Pro Ser Arg Pro Gly Ser Thr Ala Phe Pro Ser Gln
        275                 280                 285             
Asp Gly Glu Thr Gly Gly His Arg Arg Ser Phe Pro Pro Arg Thr Asn
    290                 295                 300                 
Pro Asp Lys Ile Ala Gln Arg Lys Ser Ser Met Asn Gln Leu Gln Gln
305                 310                 315                 320 
Trp Val Asn Leu Arg Arg Gly Val Pro Pro Pro Glu Asp Leu Arg Ser
                325                 330                 335     
Pro Ser Arg Phe Tyr Pro Val Ser Arg Arg Val Pro Glu Tyr Tyr Gly
            340                 345                 350         
Pro Tyr Ser Ser Gln Tyr Pro Asp Asp Tyr Gln Tyr Tyr Pro Pro Gly
        355                 360                 365             
Val Arg Pro Glu Ser Ile Cys Ser Met Pro Ala Tyr Asp Arg Ile Ser
    370                 375                 380                 
Pro Pro Trp Ala Leu Glu Asp Lys Arg His Ala Phe Arg Asn Gly Gly
385                 390                 395                 400 
Gly Pro Ala Tyr Gln Leu Arg Glu Trp Lys Glu Pro Ala Ser Tyr Gly
                405                 410                 415     
Arg Gln Asp Ala Thr Val Trp Ile Pro Ser Pro Ser Arg Gln Pro Val
            420                 425                 430         
Tyr Tyr Asp Glu Leu Asp Ala Ala Ser Ser Ser Leu Arg Arg Leu Ser
        435                 440                 445             
Leu Gln Pro Arg Ser His Ser Val Pro Arg Ser Pro Ser Gln Gly Ser
    450                 455                 460                 
Tyr Ser Arg Ala Arg Ile Tyr Ser Pro Val Arg Ser Pro Ser Ala Arg
465                 470                 475                 480 
Phe Glu Arg Leu Pro Pro Arg Ser Glu Asp Ile Tyr Ala Asp Pro Ala
                485                 490                 495     
Ala Tyr Val Met Arg Arg Ser Ile Ser Ser Pro Lys Val Pro Pro Tyr
            500                 505                 510         
Pro Glu Val Phe Arg Asp Ser Leu His Thr Tyr Lys Leu Asn Glu Gln
        515                 520                 525             
Asp Thr Asp Lys Leu Leu Gly Lys Leu Cys Glu Gln Asn Lys Val Val
    530                 535                 540                 
Arg Glu Gln Asp Arg Leu Val Gln Gln Leu Arg Ala Glu Lys Glu Ser
545                 550                 555                 560 
Leu Glu Ser Ala Leu Met Gly Thr His Gln Glu Leu Glu Met Phe Gly
                565                 570                 575     
Ser Gln Pro Ala Tyr Pro Glu Lys Leu Arg His Lys Lys Asp Ser Leu
            580                 585                 590         
Gln Asn Gln Leu Ile Asn Ile Arg Val Glu Leu Ser Gln Ala Thr Thr
        595                 600                 605             
Ala Leu Thr Asn Ser Thr Ile Glu Tyr Glu His Leu Glu Ser Glu Val
    610                 615                 620                 
Ser Ala Leu His Asp Asp Leu Trp Glu Gln Leu Asn Leu Asp Thr Gln
625                 630                 635                 640 
Asn Glu Val Leu Asn Arg Gln Ile Gln Lys Glu Ile Trp Arg Ile Gln
                645                 650                 655     
Asp Val Met Glu Gly Leu Arg Lys Asn Asn Pro Ser Arg Gly Thr Asp
            660                 665                 670         
Thr Ala Lys His Arg Gly Gly Leu Gly Pro Ser Ala Thr Tyr Ser Ser
        675                 680                 685             
Asn Ser Pro Ala Ser Pro Leu Ser Ser Ala Ser Leu Thr Ser Pro Leu
    690                 695                 700                 
Ser Pro Phe Ser Leu Val Ser Gly Ser Gln Gly Ser Pro Thr Lys Pro
705                 710                 715                 720 
Gly Ser Asn Glu Pro Lys Ala Asn Tyr Glu Gln Ser Lys Lys Asp Pro
                725                 730                 735     
His Gln Thr Leu Pro Leu Asp Thr Pro Arg Asp Ile Ser Leu Val Pro
            740                 745                 750         
Thr Arg Gln Glu Val Glu Ala Glu Lys Gln Ala Ala Leu Asn Lys Val
        755                 760                 765             
Gly Val Val Pro Pro Arg Thr Lys Ser Pro Thr Asp Asp Glu Val Thr
    770                 775                 780                 
Pro Ser Ala Val Val Arg Arg Asn Ala Ser Gly Leu Thr Asn Gly Leu
785                 790                 795                 800 
Ser Ser Gln Glu Arg Pro Lys Ser Ala Val Phe Pro Gly Glu Gly Lys
                805                 810                 815     
Val Lys Met Ser Val Glu Glu Gln Ile Asp Arg Met Arg Arg His Gln
            820                 825                 830         
Ser Gly Ser Met Lys Glu Lys Arg Arg Ser Leu Gln Leu Pro Ala Ser
        835                 840                 845             
Pro Ala Pro Asp Pro Ser Pro Arg Pro Ala Tyr Lys Val Val Arg Arg
    850                 855                 860                 
His Arg Ser Ile His Glu Val Asp Ile Ser Asn Leu Glu Ala Ala Leu
865                 870                 875                 880 
Arg Ala Glu Glu Pro Gly Gly His Ala Tyr Glu Thr Pro Arg Glu Glu
                885                 890                 895     
Ile Ala Arg Leu Arg Lys Met Glu Leu Glu Pro Gln His Tyr Asp Val
            900                 905                 910         
Asp Ile Asn Lys Glu Leu Ser Thr Pro Asp Lys Val Leu Ile Pro Glu
        915                 920                 925             
Arg Tyr Ile Asp Leu Glu Pro Asp Thr Pro Leu Ser Pro Glu Glu Leu
    930                 935                 940                 
Lys Glu Lys Gln Lys Lys Val Glu Arg Ile Lys Thr Leu Ile Ala Lys
945                 950                 955                 960 
Ser Ser Met Gln Asn Val Val Pro Ile Gly Glu Gly Asp Ser Val Asp
                965                 970                 975     
Val Pro Gln Asp Ser Glu Ser Gln Leu Gln Glu Gln Glu Lys Arg Ile
            980                 985                 990         
Glu Ile Ser Cys Ala Leu Ala Thr Glu Ala Ser Arg Arg Gly Arg Met
        995                 1000                1005            
Leu Ser Val Gln Cys Ala Thr Pro Ser Pro Pro Thr Ser Pro Ala Ser
    1010                1015                1020                
Pro Ala Pro Pro Ala Asn Pro Leu Ser Ser Glu Ser Pro Arg Gly Ala
1025                1030                1035                1040
Asp Ser Ser Tyr Thr Met Arg Val
                1045            


<210> 7269
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7269
Met Asn Pro Arg Asp Lys Gln Val Ser Arg Phe Ser Pro Leu Lys Asp
 1               5                  10                  15      
Val Tyr Thr Trp Val Ala Leu Ala Gly Ile Gln Arg Ser Gly Ser Pro
            20                  25                  30          
Gly Arg Thr Arg Ser Ala Ala Arg Arg Met Glu Ser Asn Thr Ser Ser
        35                  40                  45              
Ser Leu Glu Asn Leu Ala Thr Ala Pro Val Asn Gln Ile Gln Glu Thr
    50                  55                  60                  
Ile Ser Asp Asn Cys Val Val Ile Phe Ser Lys Thr Ser Cys Ser Tyr
65                  70                  75                  80  
Cys Thr Met Ala Lys Lys Leu Phe His Asp Met Asn Val Asn Tyr Lys
                85                  90                  95      
Val Val Glu Leu Asp Leu Leu Glu Tyr Gly Asn Gln Phe Gln Asp Ala
            100                 105                 110         
Leu Tyr Lys Met Thr Gly Glu Arg Thr Val Pro Arg Ile Phe Val Asn
        115                 120                 125             
Gly Thr Phe Ile Gly Gly Ala Thr Asp Thr His Arg Leu His Lys Glu
    130                 135                 140                 
Gly Lys Leu Leu Pro Leu Val His Gln Cys Tyr Leu Lys Lys Ser Lys
145                 150                 155                 160 
Arg Lys Glu Phe Gln
                165 


<210> 7270
<211> 201
<212> PRT
<213> Homo sapiens

<400> 7270
Met Ala Ala Arg Thr Ala Phe Gly Ala Val Cys Arg Arg Leu Trp Gln
 1               5                  10                  15      
Gly Leu Gly Asn Phe Ser Val Asn Thr Ser Lys Gly Asn Thr Ala Lys
            20                  25                  30          
Asn Gly Gly Leu Leu Leu Ser Thr Asn Met Lys Trp Val Gln Phe Ser
        35                  40                  45              
Asn Leu His Val Asp Val Pro Lys Asp Leu Thr Lys Pro Val Val Thr
    50                  55                  60                  
Ile Ser Asp Glu Pro Asp Ile Leu Tyr Lys Arg Leu Ser Val Leu Val
65                  70                  75                  80  
Lys Gly His Asp Lys Ala Val Leu Asp Ser Tyr Glu Tyr Phe Ala Val
                85                  90                  95      
Leu Ala Ala Lys Glu Leu Gly Ile Ser Ile Lys Val His Glu Pro Pro
            100                 105                 110         
Arg Lys Ile Glu Arg Phe Thr Leu Leu Gln Ser Val His Ile Tyr Lys
        115                 120                 125             
Lys His Arg Val Gln Tyr Glu Met Arg Thr Leu Tyr Arg Cys Leu Glu
    130                 135                 140                 
Leu Glu His Leu Thr Gly Ser Thr Ala Asp Val Tyr Leu Glu Tyr Ile
145                 150                 155                 160 
Gln Arg Asn Leu Pro Glu Gly Val Ala Met Glu Val Thr Lys Thr Gln
                165                 170                 175     
Leu Glu Gln Leu Pro Glu His Ile Lys Glu Pro Ile Trp Glu Thr Leu
            180                 185                 190         
Ser Glu Glu Lys Glu Glu Ser Lys Ser
        195                 200     


<210> 7271
<211> 471
<212> PRT
<213> Homo sapiens

<400> 7271
Met Ser Glu Glu Ser Asp Met Asp Lys Ala Ile Lys Glu Thr Ser Ile
 1               5                  10                  15      
Leu Glu Glu Tyr Ser Ile Asn Trp Thr Gln Lys Leu Gly Ala Gly Ile
            20                  25                  30          
Ser Gly Pro Val Arg Val Cys Val Lys Lys Ser Thr Gln Glu Arg Phe
        35                  40                  45              
Ala Leu Lys Ile Leu Leu Asp Arg Pro Lys Ala Arg Asn Glu Val Arg
    50                  55                  60                  
Leu His Met Met Cys Ala Thr His Pro Asn Ile Val Gln Ile Ile Glu
65                  70                  75                  80  
Val Phe Ala Asn Ser Val Gln Phe Pro His Glu Ser Ser Pro Arg Ala
                85                  90                  95      
Arg Leu Leu Ile Val Met Glu Met Met Glu Gly Gly Glu Leu Phe His
            100                 105                 110         
Arg Ile Ser Gln His Arg His Phe Thr Glu Lys Gln Ala Ser Gln Val
        115                 120                 125             
Thr Lys Gln Ile Ala Leu Ala Leu Arg His Cys His Leu Leu Asn Ile
    130                 135                 140                 
Ala His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Lys Asp Asn Ser
145                 150                 155                 160 
Leu Asp Ala Pro Val Lys Leu Cys Asp Phe Gly Phe Ala Lys Ile Asp
                165                 170                 175     
Gln Gly Asp Leu Met Thr Pro Gln Phe Thr Pro Tyr Tyr Val Ala Pro
            180                 185                 190         
Gln Val Leu Glu Ala Gln Arg Arg His Gln Lys Glu Lys Ser Gly Ile
        195                 200                 205             
Ile Pro Thr Ser Pro Thr Pro Tyr Thr Tyr Asn Lys Ser Cys Asp Leu
    210                 215                 220                 
Trp Ser Leu Gly Val Ile Ile Tyr Val Met Leu Cys Gly Tyr Pro Pro
225                 230                 235                 240 
Phe Tyr Ser Lys His His Ser Arg Thr Ile Pro Lys Asp Met Arg Arg
                245                 250                 255     
Lys Ile Met Thr Gly Ser Phe Glu Phe Pro Glu Glu Glu Trp Ser Gln
            260                 265                 270         
Ile Ser Glu Met Ala Lys Asp Val Val Arg Lys Leu Leu Lys Val Lys
        275                 280                 285             
Pro Glu Arg Arg Leu Thr Ile Glu Gly Val Leu Asp His Pro Trp Leu
    290                 295                 300                 
Asn Ser Thr Glu Ala Leu Asp Asn Val Leu Pro Ser Ala Gln Leu Met
305                 310                 315                 320 
Met Asp Lys Ala Val Val Ala Gly Ile Gln Gln Ala His Ala Glu Gln
                325                 330                 335     
Leu Ala Asn Met Arg Ile Gln Asp Leu Lys Val Ser Leu Lys Pro Leu
            340                 345                 350         
His Ser Val Asn Asn Pro Ile Leu Arg Lys Arg Lys Leu Leu Gly Thr
        355                 360                 365             
Lys Pro Lys Asp Ser Val Tyr Ile His Asp His Glu Asn Gly Ala Glu
    370                 375                 380                 
Asp Ser Asn Val Ala Leu Glu Lys Leu Arg Asp Val Ile Ala Gln Cys
385                 390                 395                 400 
Ile Leu Pro Gln Ala Gly Glu Asn Glu Asp Glu Lys Leu Asn Glu Val
                405                 410                 415     
Met Gln Glu Ala Trp Lys Tyr Asn Arg Glu Cys Lys Leu Leu Arg Asp
            420                 425                 430         
Thr Leu Gln Ser Phe Ser Trp Asn Gly Arg Gly Phe Thr Asp Lys Val
        435                 440                 445             
Asp Arg Leu Lys Leu Ala Glu Ile Val Lys Gln Val Ile Glu Glu Gln
    450                 455                 460                 
Thr Thr Ser His Glu Ser Gln
465                 470     


<210> 7272
<211> 271
<212> PRT
<213> Homo sapiens

<400> 7272
Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser
 1               5                  10                  15      
Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln
            20                  25                  30          
Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met
        35                  40                  45              
Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys
    50                  55                  60                  
Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val
65                  70                  75                  80  
Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp
                85                  90                  95      
Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg
            100                 105                 110         
Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg
        115                 120                 125             
Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile
    130                 135                 140                 
Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu
145                 150                 155                 160 
Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp
                165                 170                 175     
Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr
            180                 185                 190         
Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro
        195                 200                 205             
Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe
    210                 215                 220                 
Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro
225                 230                 235                 240 
Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly
                245                 250                 255     
Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala
            260                 265                 270     


<210> 7273
<211> 1032
<212> PRT
<213> Homo sapiens

<400> 7273
Met Ser Gln Gln Gly Tyr Val Ala Thr Pro Pro Tyr Ser Gln Pro Gln
 1               5                  10                  15      
Pro Gly Ile Gly Leu Ser Pro Pro His Tyr Gly His Tyr Gly Asp Pro
            20                  25                  30          
Ser His Thr Ala Ser Pro Thr Gly Met Met Lys Pro Ala Gly Pro Leu
        35                  40                  45              
Gly Ala Thr Ala Thr Arg Gly Met Leu Pro Pro Gly Pro Pro Pro Pro
    50                  55                  60                  
Gly Pro His Gln Phe Gly Gln Asn Gly Ala His Ala Thr Gly His Pro
65                  70                  75                  80  
Pro Gln Arg Phe Pro Gly Pro Pro Pro Val Asn Asn Val Ala Ser Ser
                85                  90                  95      
His Ala Pro Tyr Gln Pro Ser Ala Gln Ser Ser Tyr Pro Gly Pro Ile
            100                 105                 110         
Ser Thr Ser Ser Val Thr Gln Leu Gly Ser Gln Leu Ser Ala Met Gln
        115                 120                 125             
Ile Asn Ser Tyr Gly Ser Gly Met Ala Pro Pro Ser Gln Gly Pro Pro
    130                 135                 140                 
Gly Pro Leu Ser Ala Thr Ser Leu Gln Thr Pro Pro Arg Pro Pro Gln
145                 150                 155                 160 
Pro Ser Ile Leu Gln Pro Gly Ser Gln Val Leu Pro Pro Pro Pro Thr
                165                 170                 175     
Thr Leu Asn Gly Pro Gly Ala Ser Pro Leu Pro Leu Pro Met Tyr Arg
            180                 185                 190         
Pro Asp Gly Leu Ser Gly Pro Pro Pro Pro Asn Ala Gln Tyr Gln Pro
        195                 200                 205             
Pro Pro Leu Pro Gly Gln Thr Leu Gly Ala Gly Tyr Pro Pro Gln Gln
    210                 215                 220                 
Ala Asn Ser Gly Pro Gln Met Ala Gly Ala Gln Leu Ser Tyr Pro Gly
225                 230                 235                 240 
Gly Phe Pro Gly Gly Pro Ala Gln Met Ala Gly Pro Pro Gln Pro Gln
                245                 250                 255     
Lys Lys Leu Asp Pro Asp Ser Ile Pro Ser Pro Ile Gln Val Ile Glu
            260                 265                 270         
Asn Asp Arg Ala Ser Arg Gly Gly Gln Val Tyr Ala Thr Asn Thr Arg
        275                 280                 285             
Gly Gln Ile Pro Pro Leu Val Thr Thr Asp Cys Met Ile Gln Asp Gln
    290                 295                 300                 
Gly Asn Ala Ser Pro Arg Phe Ile Arg Cys Thr Thr Tyr Cys Phe Pro
305                 310                 315                 320 
Cys Thr Ser Asp Met Ala Lys Gln Ala Gln Ile Pro Leu Ala Ala Val
                325                 330                 335     
Ile Lys Pro Phe Ala Thr Ile Pro Ser Asn Glu Ser Pro Leu Tyr Leu
            340                 345                 350         
Val Asn His Gly Glu Ser Gly Pro Val Arg Cys Asn Arg Cys Lys Ala
        355                 360                 365             
Tyr Met Cys Pro Phe Met Gln Phe Ile Glu Gly Gly Arg Arg Tyr Gln
    370                 375                 380                 
Cys Gly Phe Cys Asn Cys Val Asn Asp Val Pro Pro Phe Tyr Phe Gln
385                 390                 395                 400 
His Leu Asp His Ile Gly Arg Arg Leu Asp His Tyr Glu Lys Pro Glu
                405                 410                 415     
Leu Ser Leu Gly Ser Tyr Glu Tyr Val Ala Thr Leu Asp Tyr Cys Arg
            420                 425                 430         
Lys Ser Lys Pro Pro Asn Pro Pro Ala Phe Ile Phe Met Ile Asp Val
        435                 440                 445             
Ser Tyr Ser Asn Ile Lys Asn Gly Leu Val Lys Leu Ile Cys Glu Glu
    450                 455                 460                 
Leu Lys Thr Met Leu Glu Lys Ile Pro Lys Glu Glu Gln Glu Glu Thr
465                 470                 475                 480 
Ser Ala Ile Arg Val Gly Phe Ile Thr Tyr Asn Lys Val Leu His Phe
                485                 490                 495     
Phe Asn Val Lys Ser Asn Leu Ala Gln Pro Gln Met Met Val Val Thr
            500                 505                 510         
Asp Val Gly Glu Val Phe Val Pro Leu Leu Asp Gly Phe Leu Val Asn
        515                 520                 525             
Tyr Gln Glu Ser Gln Ser Val Ile His Asn Leu Leu Asp Gln Ile Pro
    530                 535                 540                 
Asp Met Phe Ala Asp Ser Asn Glu Asn Glu Thr Val Phe Ala Ser Val
545                 550                 555                 560 
Ile Gln Ala Gly Met Glu Ala Leu Lys Ala Ala Asp Cys Pro Gly Lys
                565                 570                 575     
Leu Phe Ile Phe His Ser Ser Leu Pro Thr Ala Glu Ala Pro Gly Lys
            580                 585                 590         
Leu Lys Asn Arg Asp Asp Lys Lys Leu Val Asn Thr Asp Lys Glu Lys
        595                 600                 605             
Ile Leu Phe Gln Pro Gln Thr Asn Val Tyr Asp Ser Leu Ala Lys Asp
    610                 615                 620                 
Cys Val Ala His Gly Cys Ser Val Thr Leu Phe Leu Phe Pro Ser Gln
625                 630                 635                 640 
Tyr Val Asp Val Ala Ser Leu Gly Leu Val Pro Gln Leu Thr Gly Gly
                645                 650                 655     
Thr Leu Tyr Lys Tyr Asn Asn Phe Gln Met His Leu Asp Arg Gln Gln
            660                 665                 670         
Phe Leu Asn Asp Leu Arg Asn Asp Ile Glu Lys Lys Ile Gly Phe Asp
        675                 680                 685             
Ala Ile Met Arg Val Arg Thr Ser Thr Gly Phe Arg Ala Thr Asp Phe
    690                 695                 700                 
Phe Gly Gly Ile Leu Met Asn Asn Thr Thr Asp Val Glu Met Ala Ala
705                 710                 715                 720 
Ile Asp Cys Asp Lys Ala Val Thr Val Glu Phe Lys His Asp Asp Lys
                725                 730                 735     
Leu Ser Glu Asp Ser Gly Ala Leu Ile Gln Cys Ala Val Leu Tyr Thr
            740                 745                 750         
Thr Ile Ser Gly Gln Arg Arg Leu Arg Ile His Asn Leu Gly Leu Asn
        755                 760                 765             
Cys Ser Ser Gln Leu Ala Asp Leu Tyr Lys Ser Cys Glu Thr Asp Ala
    770                 775                 780                 
Leu Ile Asn Phe Phe Ala Lys Ser Ala Phe Lys Ala Val Leu His Gln
785                 790                 795                 800 
Pro Leu Lys Val Ile Arg Glu Ile Leu Val Asn Gln Thr Ala His Met
                805                 810                 815     
Leu Ala Cys Tyr Arg Lys Asn Cys Ala Ser Pro Ser Ala Ala Ser Gln
            820                 825                 830         
Leu Ile Leu Pro Asp Ser Met Lys Val Leu Pro Val Tyr Met Asn Cys
        835                 840                 845             
Leu Leu Lys Asn Cys Val Leu Leu Ser Arg Pro Glu Ile Ser Thr Asp
    850                 855                 860                 
Glu Arg Ala Tyr Gln Arg Gln Leu Val Met Thr Met Gly Val Ala Asp
865                 870                 875                 880 
Ser Gln Leu Phe Phe Tyr Pro Gln Leu Leu Pro Ile His Thr Leu Asp
                885                 890                 895     
Val Lys Ser Thr Met Leu Pro Ala Ala Val Arg Cys Ser Glu Ser Arg
            900                 905                 910         
Leu Ser Glu Glu Gly Ile Phe Leu Leu Ala Asn Gly Leu His Met Phe
        915                 920                 925             
Leu Trp Leu Gly Val Ser Ser Pro Pro Glu Leu Ile Gln Gly Ile Phe
    930                 935                 940                 
Asn Val Pro Ser Phe Ala His Ile Asn Thr Asp Met Thr Leu Leu Pro
945                 950                 955                 960 
Glu Val Gly Asn Pro Tyr Ser Gln Gln Leu Arg Met Ile Met Gly Ile
                965                 970                 975     
Ile Gln Gln Lys Arg Pro Tyr Ser Met Lys Leu Thr Ile Val Lys Gln
            980                 985                 990         
Arg Glu Gln Pro Glu Met Val Phe Arg Gln Phe Leu Val Glu Asp Lys
        995                 1000                1005            
Gly Leu Tyr Gly Gly Ser Ser Tyr Val Asp Phe Leu Cys Cys Val His
    1010                1015                1020                
Lys Glu Ile Cys Gln Leu Leu Asn
1025                1030        


<210> 7274
<211> 894
<212> PRT
<213> Homo sapiens

<400> 7274
Met Ser Arg Arg Lys Gln Gly Asn Pro Gln His Leu Ser Gln Arg Glu
 1               5                  10                  15      
Leu Ile Thr Pro Glu Ala Asp His Val Glu Ala Ala Ile Leu Glu Glu
            20                  25                  30          
Asp Glu Gly Leu Glu Ile Glu Glu Pro Ser Gly Leu Gly Leu Met Val
        35                  40                  45              
Gly Gly Pro Asp Pro Asp Leu Leu Thr Cys Gly Gln Cys Gln Met Asn
    50                  55                  60                  
Phe Pro Leu Gly Asp Ile Leu Val Phe Ile Glu His Lys Arg Lys Gln
65                  70                  75                  80  
Cys Gly Gly Ser Leu Gly Ala Cys Tyr Asp Lys Ala Leu Asp Lys Asp
                85                  90                  95      
Ser Pro Pro Pro Ser Ser Arg Ser Glu Leu Arg Lys Val Ser Glu Pro
            100                 105                 110         
Val Glu Ile Gly Ile Gln Val Thr Pro Asp Glu Asp Asp His Leu Leu
        115                 120                 125             
Ser Pro Thr Lys Gly Ile Cys Pro Lys Gln Glu Asn Ile Ala Gly Pro
    130                 135                 140                 
Cys Arg Pro Ala Gln Leu Pro Ala Val Ala Pro Ile Ala Ala Ser Ser
145                 150                 155                 160 
His Pro His Ser Ser Val Ile Thr Ser Pro Leu Arg Ala Leu Gly Ala
                165                 170                 175     
Leu Pro Pro Cys Leu Pro Leu Pro Cys Cys Ser Ala Arg Pro Val Ser
            180                 185                 190         
Gly Asp Gly Thr Gln Gly Glu Gly Gln Thr Glu Ala Pro Phe Gly Cys
        195                 200                 205             
Gln Cys Gln Leu Ser Gly Lys Asp Glu Pro Ser Ser Tyr Ile Cys Thr
    210                 215                 220                 
Thr Cys Lys Gln Pro Phe Asn Ser Ala Trp Phe Leu Leu Gln His Ala
225                 230                 235                 240 
Gln Asn Thr His Gly Phe Arg Ile Tyr Leu Glu Pro Gly Pro Ala Ser
                245                 250                 255     
Ser Ser Leu Thr Pro Arg Leu Thr Ile Pro Pro Pro Leu Gly Pro Glu
            260                 265                 270         
Ala Val Ala Gln Ser Pro Leu Met Asn Phe Leu Gly Asp Ser Asn Pro
        275                 280                 285             
Phe Asn Leu Leu Arg Met Thr Gly Pro Ile Leu Arg Asp His Pro Gly
    290                 295                 300                 
Phe Gly Glu Gly Arg Leu Pro Gly Thr Pro Pro Leu Phe Ser Pro Pro
305                 310                 315                 320 
Pro Arg His His Leu Asp Pro His Arg Leu Ser Ala Glu Glu Met Gly
                325                 330                 335     
Leu Val Ala Gln His Pro Ser Ala Phe Asp Arg Val Met Arg Leu Asn
            340                 345                 350         
Pro Met Ala Ile Asp Ser Pro Ala Met Asp Phe Ser Arg Arg Leu Arg
        355                 360                 365             
Glu Leu Ala Gly Asn Ser Ser Thr Pro Pro Pro Val Ser Pro Gly Arg
    370                 375                 380                 
Gly Asn Pro Met His Arg Leu Leu Asn Pro Phe Gln Pro Ser Pro Lys
385                 390                 395                 400 
Ser Pro Phe Leu Ser Thr Pro Pro Leu Pro Pro Met Pro Pro Gly Gly
                405                 410                 415     
Thr Pro Pro Pro Gln Pro Pro Ala Lys Ser Lys Ser Cys Glu Phe Cys
            420                 425                 430         
Gly Lys Thr Phe Lys Phe Gln Ser Asn Leu Ile Val His Arg Arg Ser
        435                 440                 445             
His Thr Gly Glu Lys Pro Tyr Lys Cys Gln Leu Cys Asp His Ala Cys
    450                 455                 460                 
Ser Gln Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys
465                 470                 475                 480 
Ala Gly Ser Leu Ala Gly Arg Ser Asp Asp Gly Leu Ser Ala Ala Ser
                485                 490                 495     
Ser Pro Glu Pro Gly Thr Ser Glu Leu Ala Gly Glu Gly Leu Lys Ala
            500                 505                 510         
Ala Asp Gly Asp Phe Arg His His Glu Ser Asp Pro Ser Leu Gly His
        515                 520                 525             
Glu Pro Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu
    530                 535                 540                 
Leu Leu Glu Asn Glu Ser Arg Pro Glu Ser Ser Phe Ser Met Asp Ser
545                 550                 555                 560 
Glu Leu Ser Arg Asn Arg Glu Asn Gly Gly Gly Gly Val Pro Gly Val
                565                 570                 575     
Pro Gly Ala Gly Gly Gly Ala Ala Lys Ala Leu Ala Asp Glu Lys Ala
            580                 585                 590         
Leu Val Leu Gly Lys Val Met Glu Asn Val Gly Leu Gly Ala Leu Pro
        595                 600                 605             
Gln Tyr Gly Glu Leu Leu Ala Asp Lys Gln Lys Arg Gly Ala Phe Leu
    610                 615                 620                 
Lys Arg Ala Ala Gly Gly Gly Asp Ala Gly Asp Asp Asp Asp Ala Gly
625                 630                 635                 640 
Gly Cys Gly Asp Ala Gly Ala Gly Gly Ala Val Asn Gly Arg Gly Gly
                645                 650                 655     
Gly Phe Ala Pro Gly Thr Glu Pro Phe Pro Gly Leu Phe Pro Arg Lys
            660                 665                 670         
Pro Ala Pro Leu Pro Ser Pro Gly Leu Asn Ser Ala Ala Lys Arg Ile
        675                 680                 685             
Lys Val Glu Lys Asp Leu Glu Leu Pro Pro Ala Ala Leu Ile Pro Ser
    690                 695                 700                 
Glu Asn Val Tyr Ser Gln Trp Leu Val Gly Tyr Ala Ala Ser Arg His
705                 710                 715                 720 
Phe Met Lys Asp Pro Phe Leu Gly Phe Thr Asp Ala Arg Gln Ser Pro
                725                 730                 735     
Phe Ala Thr Ser Ser Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe
            740                 745                 750         
Ser Thr Pro Pro Gly Asp Leu Leu Asp Gly Gly Leu Ser Gly Arg Ser
        755                 760                 765             
Gly Thr Ala Ser Gly Gly Ser Thr Pro His Leu Gly Gly Pro Gly Pro
    770                 775                 780                 
Gly Arg Pro Ser Ser Lys Glu Gly Arg Arg Ser Asp Thr Cys Glu Tyr
785                 790                 795                 800 
Cys Gly Lys Val Phe Lys Asn Cys Ser Asn Leu Thr Val His Arg Arg
                805                 810                 815     
Ser His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala
            820                 825                 830         
Cys Ala Gln Ser Ser Lys Leu Thr Arg His Met Lys Thr His Gly Gln
        835                 840                 845             
Ile Gly Lys Glu Val Tyr Arg Cys Asp Ile Cys Gln Met Pro Phe Ser
    850                 855                 860                 
Val Tyr Ser Thr Leu Glu Lys His Met Lys Lys Trp His Gly Glu His
865                 870                 875                 880 
Leu Leu Thr Asn Asp Val Lys Ile Glu Gln Ala Glu Arg Ser
                885                 890                 


<210> 7275
<211> 823
<212> PRT
<213> Homo sapiens

<400> 7275
Met Ser Arg Arg Lys Gln Gly Asn Pro Gln His Leu Ser Gln Arg Glu
 1               5                  10                  15      
Leu Ile Thr Pro Glu Ala Asp His Val Glu Ala Ala Ile Leu Glu Glu
            20                  25                  30          
Asp Glu Gly Leu Glu Ile Glu Glu Pro Ser Gly Leu Gly Leu Met Val
        35                  40                  45              
Gly Gly Pro Asp Pro Asp Leu Leu Thr Cys Gly Gln Cys Gln Met Asn
    50                  55                  60                  
Phe Pro Leu Gly Asp Ile Leu Val Phe Ile Glu His Lys Arg Lys Gln
65                  70                  75                  80  
Cys Gly Gly Ser Leu Gly Ala Cys Tyr Asp Lys Ala Leu Asp Lys Asp
                85                  90                  95      
Ser Pro Pro Pro Ser Ser Arg Ser Glu Leu Arg Lys Val Ser Glu Pro
            100                 105                 110         
Val Glu Ile Gly Ile Gln Val Thr Pro Asp Glu Asp Asp His Leu Leu
        115                 120                 125             
Ser Pro Thr Lys Gly Ile Cys Pro Lys Gln Glu Asn Ile Ala Gly Lys
    130                 135                 140                 
Asp Glu Pro Ser Ser Tyr Ile Cys Thr Thr Cys Lys Gln Pro Phe Asn
145                 150                 155                 160 
Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr His Gly Phe Arg
                165                 170                 175     
Ile Tyr Leu Glu Pro Gly Pro Ala Ser Ser Ser Leu Thr Pro Arg Leu
            180                 185                 190         
Thr Ile Pro Pro Pro Leu Gly Pro Glu Ala Val Ala Gln Ser Pro Leu
        195                 200                 205             
Met Asn Phe Leu Gly Asp Ser Asn Pro Phe Asn Leu Leu Arg Met Thr
    210                 215                 220                 
Gly Pro Ile Leu Arg Asp His Pro Gly Phe Gly Glu Gly Arg Leu Pro
225                 230                 235                 240 
Gly Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His His Leu Asp Pro
                245                 250                 255     
His Arg Leu Ser Ala Glu Glu Met Gly Leu Val Ala Gln His Pro Ser
            260                 265                 270         
Ala Phe Asp Arg Val Met Arg Leu Asn Pro Met Ala Ile Asp Ser Pro
        275                 280                 285             
Ala Met Asp Phe Ser Arg Arg Leu Arg Glu Leu Ala Gly Asn Ser Ser
    290                 295                 300                 
Thr Pro Pro Pro Val Ser Pro Gly Arg Gly Asn Pro Met His Arg Leu
305                 310                 315                 320 
Leu Asn Pro Phe Gln Pro Ser Pro Lys Ser Pro Phe Leu Ser Thr Pro
                325                 330                 335     
Pro Leu Pro Pro Met Pro Pro Gly Gly Thr Pro Pro Pro Gln Pro Pro
            340                 345                 350         
Ala Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys Thr Phe Lys Phe Gln
        355                 360                 365             
Ser Asn Leu Ile Val His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr
    370                 375                 380                 
Lys Cys Gln Leu Cys Asp His Ala Cys Ser Gln Ala Ser Lys Leu Lys
385                 390                 395                 400 
Arg His Met Lys Thr His Met His Lys Ala Gly Ser Leu Ala Gly Arg
                405                 410                 415     
Ser Asp Asp Gly Leu Ser Ala Ala Ser Ser Pro Glu Pro Gly Thr Ser
            420                 425                 430         
Glu Leu Ala Gly Glu Gly Leu Lys Ala Ala Asp Gly Asp Phe Arg His
        435                 440                 445             
His Glu Ser Asp Pro Ser Leu Gly His Glu Pro Glu Glu Glu Asp Glu
    450                 455                 460                 
Glu Glu Glu Glu Glu Glu Glu Glu Leu Leu Leu Glu Asn Glu Ser Arg
465                 470                 475                 480 
Pro Glu Ser Ser Phe Ser Met Asp Ser Glu Leu Ser Arg Asn Arg Glu
                485                 490                 495     
Asn Gly Gly Gly Gly Val Pro Gly Val Pro Gly Ala Gly Gly Gly Ala
            500                 505                 510         
Ala Lys Ala Leu Ala Asp Glu Lys Ala Leu Val Leu Gly Lys Val Met
        515                 520                 525             
Glu Asn Val Gly Leu Gly Ala Leu Pro Gln Tyr Gly Glu Leu Leu Ala
    530                 535                 540                 
Asp Lys Gln Lys Arg Gly Ala Phe Leu Lys Arg Ala Ala Gly Gly Gly
545                 550                 555                 560 
Asp Ala Gly Asp Asp Asp Asp Ala Gly Gly Cys Gly Asp Ala Gly Ala
                565                 570                 575     
Gly Gly Ala Val Asn Gly Arg Gly Gly Gly Phe Ala Pro Gly Thr Glu
            580                 585                 590         
Pro Phe Pro Gly Leu Phe Pro Arg Lys Pro Ala Pro Leu Pro Ser Pro
        595                 600                 605             
Gly Leu Asn Ser Ala Ala Lys Arg Ile Lys Val Glu Lys Asp Leu Glu
    610                 615                 620                 
Leu Pro Pro Ala Ala Leu Ile Pro Ser Glu Asn Val Tyr Ser Gln Trp
625                 630                 635                 640 
Leu Val Gly Tyr Ala Ala Ser Arg His Phe Met Lys Asp Pro Phe Leu
                645                 650                 655     
Gly Phe Thr Asp Ala Arg Gln Ser Pro Phe Ala Thr Ser Ser Glu His
            660                 665                 670         
Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly Asp Leu
        675                 680                 685             
Leu Asp Gly Gly Leu Ser Gly Arg Ser Gly Thr Ala Ser Gly Gly Ser
    690                 695                 700                 
Thr Pro His Leu Gly Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys Glu
705                 710                 715                 720 
Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys Asn
                725                 730                 735     
Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg Pro
            740                 745                 750         
Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu
        755                 760                 765             
Thr Arg His Met Lys Thr His Gly Gln Ile Gly Lys Glu Val Tyr Arg
    770                 775                 780                 
Cys Asp Ile Cys Gln Met Pro Phe Ser Val Tyr Ser Thr Leu Glu Lys
785                 790                 795                 800 
His Met Lys Lys Trp His Gly Glu His Leu Leu Thr Asn Asp Val Lys
                805                 810                 815     
Ile Glu Gln Ala Glu Arg Ser
            820             


<210> 7276
<211> 684
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 60, 130, 516, 584, 629
<223> Xaa = Any Amino Acid

<400> 7276
Met Ala Thr Asp Lys Ser His Cys Ser Asn Phe Tyr Asn Pro Ile Ile
 1               5                  10                  15      
Lys Glu Met Asn Ile Phe Ile Phe Leu Asn Lys Ser His His Leu Asn
            20                  25                  30          
Lys Pro Gly Ala Pro Met Asn His Pro Gly Asn Gly Asp Glu Val Asn
        35                  40                  45              
Glu Asp Lys Val Met Val Lys Gln Leu His Gly Xaa Glu Thr His Ile
    50                  55                  60                  
Ser Lys Lys Cys Cys Ala Glu Leu Phe Ser Ile Ser Glu Phe Leu Glu
65                  70                  75                  80  
His Lys Lys Asn Arg Thr Lys Asn Pro Pro Val Leu Thr Met Asn Asp
                85                  90                  95      
Ser Glu Glu Ser Val Pro Ser Glu Asp Phe Cys Ala Ala Val Pro Ser
            100                 105                 110         
His Gln Pro Pro Ser Ser Ser Ser Asp Ser Pro Lys Glu Asn Gly Gly
        115                 120                 125             
Ser Xaa Gly Tyr Ile Lys Glu Lys Leu Gly Ala Glu Ser Leu Leu His
    130                 135                 140                 
Leu Lys Thr Glu Thr Ala Leu Pro Ser Thr Leu Gln Asn Ile Ser Tyr
145                 150                 155                 160 
Leu Pro Lys Gly Lys Val Ala Asn Ile Asn Val Thr Leu Gln Ala Leu
                165                 170                 175     
Gln Gly Asp Lys Gly Val Ala Asn Thr Leu Lys Thr Leu Asp Ser His
            180                 185                 190         
Met Ser Lys Gln Val Ser Val Ala Val Ala Leu Leu Ser Gln Lys Ala
        195                 200                 205             
Gly Ser Gln Gly Leu Ser Leu Asp Thr Leu Asn Lys Pro Ser Tyr Leu
    210                 215                 220                 
Thr Ser Ile Pro Ser Ala Ala Ser Ser Val Thr Pro Trp Leu Thr Pro
225                 230                 235                 240 
Phe Thr Leu Lys Leu Asp Arg Thr Arg Val Leu Leu Asn Ile Val Ser
                245                 250                 255     
Gln Leu Pro Ser Ala Leu Leu Pro Gln Ala Leu Gly Ser Val Leu Phe
            260                 265                 270         
Gln Ser Pro Phe Ser Thr Val Ala Leu Tyr Pro Ser Lys Lys Glu Lys
        275                 280                 285             
Asp Lys Pro Pro Asn Thr Glu Met Cys Val Lys Pro Lys Asp Glu Ala
    290                 295                 300                 
Ile Leu Tyr Lys His Asn Cys Lys Asn Cys Ser Lys Val Trp Glu Thr
305                 310                 315                 320 
Gly Ser Ser Leu Gln Ile Tyr Pro His Met His Thr Gly Glu Arg Pro
                325                 330                 335     
Phe Met Phe Ser Val Cys Gly His Gly Phe Thr Thr Lys Glu Ser Lys
            340                 345                 350         
Gly Gly Pro Thr Leu Pro Gly Val Val Pro Asn His Asn Ser Pro Arg
        355                 360                 365             
Val Gly Gly Phe Gln Gly Ser Gly Thr Thr Lys Pro Gly Ser Glu Thr
    370                 375                 380                 
Met Lys Leu Gln Gln Leu Val Glu Asn Ser Asn Lys Ala Thr Ser Asp
385                 390                 395                 400 
Pro Thr Phe Ser Thr Lys Gly Asn Val Lys Thr Leu Leu Arg Val His
                405                 410                 415     
Gly Thr Asn Ser Ser Ile Ser Thr Tyr Pro Ile Ser Gln Lys Lys Phe
            420                 425                 430         
Ala Ser Val Val Met Leu Gln Gln His Ile Trp Met Asn Met Gly Thr
        435                 440                 445             
Gln Ile Pro Ser Met Ser Pro Pro Glu Asn Pro Cys Asp Phe Arg Gly
    450                 455                 460                 
Pro Glu Pro Met Met Val Ser Glu Asn Gly Asn Thr Ser Ala Ile Cys
465                 470                 475                 480 
His Asp Asp Val Glu Glu Asp Thr Thr Val Asp Lys Val Ser Ser Gln
                485                 490                 495     
Asp Ala Pro Ser Ser Tyr Ser Lys Val Leu Thr Pro Leu Leu Ser Ile
            500                 505                 510         
His Leu Ile Xaa Pro Thr Leu Gly Phe Ala Thr Lys Ala Ser Leu Ala
        515                 520                 525             
Val Thr Arg Lys Ala Arg Ser Leu Ala Thr Ser Gln Ala Glu Ser Ile
    530                 535                 540                 
Met Thr Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu His Pro Lys Asn
545                 550                 555                 560 
Ser His Thr Glu Met Gly Cys Leu Pro Ser Thr Ala Leu Gln Ile His
                565                 570                 575     
Lys Trp Thr His Thr Arg Glu Xaa Pro Phe Val Cys Ser Ile His Gly
            580                 585                 590         
Gln Ala Phe Thr Thr Lys Gly Asn Leu Lys Val His Cys Met Thr His
        595                 600                 605             
Gly Ala Asn Asn Asn Ser Ala His Gln Arg Arg Lys Leu Ala Ile Glu
    610                 615                 620                 
Asn Thr Met Ala Xaa Leu Val Ser Val Gly Ala Asn Ser Ala Val Asn
625                 630                 635                 640 
Asn Thr Ala Glu Ser Lys Met Asp Gly Ser Gln Ser Gly Ile Ser Ala
                645                 650                 655     
Asn Val Glu Lys Pro Gly Ala Thr Glu Thr Val Pro Thr His Trp Phe
            660                 665                 670         
Pro His Phe Leu Glu Glu Asn Lys Ile Val Val Ser
        675                 680                 


<210> 7277
<211> 502
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 395, 434, 453, 473
<223> Xaa = Any Amino Acid

<400> 7277
Met Leu Ser Ser Pro Ala His Ser Ala Met His Thr Ala Pro Pro Ser
 1               5                  10                  15      
Pro Ser Glu Glu Gly Ile Tyr Arg Ala His Thr Ala Val Gln Arg Gly
            20                  25                  30          
Thr Thr Pro Ser Ala Ala His Phe Arg Leu Gly Phe Cys Glu Arg Arg
        35                  40                  45              
Ile Asn Met Ser Phe Val Glu Val Lys Asp Lys Lys Ile Leu Arg Pro
    50                  55                  60                  
Gly Tyr Arg Ser Lys Ser Asn Leu Leu His Ser Gln Ser Pro Ser Phe
65                  70                  75                  80  
Glu Ser Ser Ala Gln Ser Leu Pro Val Leu Thr Asn Ala Val Ser Ser
                85                  90                  95      
Arg Gly Ser Met Val Leu Ala Tyr Ser Gly Ser Leu Asp Thr Ser Cys
            100                 105                 110         
Ile Phe Val Trp Leu Lys Glu Gln Gly Asn Asp Ile Ile Ala Tyr Leu
        115                 120                 125             
Gly Asn Ile Gly Gln Lys Glu Asp Phe Lys Glu Ala Arg Ala Leu Lys
    130                 135                 140                 
Pro Gly Ala Lys Lys Val Phe Thr Glu Asp Val Ser Arg Glu Phe Val
145                 150                 155                 160 
Glu Glu Phe Ile Trp Leu Ala Ile Gln Ser Ser Thr Leu Tyr Glu Asp
                165                 170                 175     
His Leu Leu Gly Ser Ser Leu Pro Arg Pro Cys Ile Ala His Lys Gln
            180                 185                 190         
Val Glu Ile Thr Gln Gln Glu Gly Ala Lys Cys Val Ser His Gly Thr
        195                 200                 205             
Thr Gly Lys Gly Asn Asp Gln Ala Arg Phe Ser Ser Pro Ala Thr Arg
    210                 215                 220                 
Trp Pro Pro Gln Ile Lys Val Ile Ala Pro Trp Cys Met Phe Glu Phe
225                 230                 235                 240 
Tyr Asn Arg Ile Lys Cys Leu Asn Asp Leu Met Glu Tyr Ala Lys Pro
                245                 250                 255     
His Gly Ile Pro Ile Pro Val Thr Pro Lys Asn Pro Trp Ser Met Asp
            260                 265                 270         
Glu Asn Leu Met His Ile Ser Tyr Glu Ala Gly Ile Leu Glu Ser Pro
        275                 280                 285             
Lys Asn Gln Ala Pro Pro Gly Cys Cys Thr Lys Thr Gln Asp Pro Ala
    290                 295                 300                 
Lys Ser Pro Asn Thr Pro Asp Ile Leu Lys Ile Glu Phe Thr Lys Gly
305                 310                 315                 320 
Val Pro Val Lys Val Thr Asn Ile Lys Asp Gly Thr Ile His Gln Thr
                325                 330                 335     
Ser Leu Glu Leu Phe Val Tyr Leu Asn Glu Val Ala Gly Lys His Arg
            340                 345                 350         
Val Gly Ser Ile Asp Ile Met Asp Asn Arg Phe Ile Gly Met Arg Ser
        355                 360                 365             
Arg Gly Ile Tyr Glu Thr Pro Ala Asp Thr Ile Leu Tyr His Ala His
    370                 375                 380                 
Leu Asp Ile Glu Ala Phe Thr Met Asp Gln Xaa Val Cys Lys Ile Lys
385                 390                 395                 400 
Gln Gly Leu Asp Leu Lys Leu Ala Glu Leu Val Tyr Thr Gly Phe Trp
                405                 410                 415     
His Ser Pro Glu Cys Glu Arg Val Arg His Cys Ile Thr Lys Ser Gln
            420                 425                 430         
Glu Xaa Val Glu Gly Lys Val Gln Val Ser Val Leu Lys Gly Gln Val
        435                 440                 445             
Tyr Ile Leu Arg Xaa Asp Ser Pro Leu Ser Leu Tyr Asn Glu Glu Leu
    450                 455                 460                 
Val Asn Met Asn Val Gln Asp His Xaa Glu Pro Ile Asp Ala Thr Gly
465                 470                 475                 480 
Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys Glu Tyr His Arg Val Gln
                485                 490                 495     
Asn Lys Val Thr Ala Lys
            500         


<210> 7278
<211> 917
<212> PRT
<213> Homo sapiens

<400> 7278
Met Phe Ala Val His Leu Met Ala Phe Tyr Phe Ser Lys Leu Lys Glu
 1               5                  10                  15      
Asp Gln Ile Lys Lys Val Asp Arg Phe Leu Tyr His Met Arg Leu Ser
            20                  25                  30          
Asp Asp Thr Leu Leu Asp Ile Met Arg Arg Phe Arg Ala Glu Met Glu
        35                  40                  45              
Lys Gly Leu Ala Lys Asp Thr Asn Pro Thr Ala Ala Val Lys Met Leu
    50                  55                  60                  
Pro Thr Phe Val Arg Ala Ile Pro Asp Gly Ser Glu Asn Gly Glu Phe
65                  70                  75                  80  
Leu Ser Leu Asp Leu Gly Gly Ser Lys Phe Arg Val Leu Lys Val Gln
                85                  90                  95      
Val Ala Glu Glu Gly Lys Arg His Val Gln Met Glu Ser Gln Phe Tyr
            100                 105                 110         
Pro Thr Pro Asn Glu Ile Ile Arg Gly Asn Gly Ile Glu Leu Phe Glu
        115                 120                 125             
Tyr Val Ala Asp Cys Leu Ala Asp Phe Met Lys Thr Lys Asp Leu Lys
    130                 135                 140                 
His Lys Lys Leu Pro Leu Gly Leu Thr Phe Ser Phe Pro Cys Arg Gln
145                 150                 155                 160 
Thr Lys Leu Glu Glu Gly Val Leu Leu Ser Trp Thr Lys Lys Phe Lys
                165                 170                 175     
Ala Arg Gly Val Gln Asp Thr Asp Val Val Ser Arg Leu Thr Lys Ala
            180                 185                 190         
Met Arg Arg His Lys Asp Met Asp Val Asp Ile Leu Ala Leu Val Asn
        195                 200                 205             
Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Asp Asp Pro Tyr Cys
    210                 215                 220                 
Glu Val Gly Val Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu
225                 230                 235                 240 
Asp Met Ser Asn Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys
                245                 250                 255     
Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ala Leu Glu Asp
            260                 265                 270         
Ile Arg Thr Glu Phe Asp Arg Glu Leu Asp Leu Gly Ser Leu Asn Pro
        275                 280                 285             
Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Leu Tyr Leu Gly Glu
    290                 295                 300                 
Leu Val Arg Leu Ile Leu Leu Lys Met Ala Lys Ala Gly Leu Leu Phe
305                 310                 315                 320 
Gly Gly Glu Lys Ser Ser Ala Leu His Thr Lys Gly Lys Ile Glu Thr
                325                 330                 335     
Arg His Val Ala Ala Met Glu Lys Tyr Lys Glu Gly Leu Ala Asn Thr
            340                 345                 350         
Arg Glu Ile Leu Val Asp Leu Gly Leu Glu Pro Ser Glu Ala Asp Cys
        355                 360                 365             
Ile Ala Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn
    370                 375                 380                 
Leu Cys Ala Ala Ala Leu Ala Ala Ile Leu Thr Arg Leu Arg Glu Asn
385                 390                 395                 400 
Lys Lys Val Glu Arg Leu Arg Thr Thr Val Gly Met Asp Gly Thr Leu
                405                 410                 415     
Tyr Lys Ile His Pro Gln Tyr Pro Lys Arg Leu His Lys Val Val Arg
            420                 425                 430         
Lys Leu Val Pro Ser Cys Asp Val Arg Phe Leu Leu Ser Glu Ser Gly
        435                 440                 445             
Ser Thr Lys Gly Ala Ala Met Val Thr Ala Val Ala Ser Arg Val Gln
    450                 455                 460                 
Ala Gln Arg Lys Gln Ile Asp Arg Val Leu Ala Leu Phe Gln Leu Thr
465                 470                 475                 480 
Arg Glu Gln Leu Val Asp Val Gln Ala Lys Ile Arg Ala Glu Leu Glu
                485                 490                 495     
Tyr Gly Leu Lys Lys Lys Ser His Gly Leu Ala Thr Val Arg Met Leu
            500                 505                 510         
Pro Thr Tyr Val Cys Gly Leu Pro Asp Gly Thr Glu Lys Gly Lys Phe
        515                 520                 525             
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys
    530                 535                 540                 
Ile Arg Ser Gly Arg Arg Ser Val Arg Met Tyr Asn Lys Ile Phe Ala
545                 550                 555                 560 
Ile Pro Leu Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His
                565                 570                 575     
Ile Val Gln Cys Ile Ala Asp Phe Leu Asp Tyr Met Gly Leu Lys Gly
            580                 585                 590         
Ala Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Arg Gln Met
        595                 600                 605             
Ser Ile Asp Lys Gly Thr Leu Ile Gly Trp Thr Lys Gly Phe Lys Ala
    610                 615                 620                 
Thr Asp Cys Glu Gly Glu Asp Val Val Asp Met Leu Arg Glu Ala Ile
625                 630                 635                 640 
Lys Arg Arg Asn Glu Phe Asp Leu Asp Ile Val Ala Val Val Asn Asp
                645                 650                 655     
Thr Val Gly Thr Met Met Thr Cys Gly Tyr Glu Asp Pro Asn Cys Glu
            660                 665                 670         
Ile Gly Leu Ile Ala Gly Thr Gly Ser Asn Met Cys Tyr Met Glu Asp
        675                 680                 685             
Met Arg Asn Ile Glu Met Val Glu Gly Gly Glu Gly Lys Met Cys Ile
    690                 695                 700                 
Asn Thr Glu Trp Gly Gly Phe Gly Asp Asn Gly Cys Ile Asp Asp Ile
705                 710                 715                 720 
Arg Thr Arg Tyr Asp Thr Glu Val Asp Glu Gly Ser Leu Asn Pro Gly
                725                 730                 735     
Lys Gln Arg Tyr Glu Lys Met Thr Ser Gly Met Tyr Leu Gly Glu Ile
            740                 745                 750         
Val Arg Gln Ile Leu Ile Asp Leu Thr Lys Gln Gly Leu Leu Phe Arg
        755                 760                 765             
Gly Gln Ile Ser Glu Arg Leu Arg Thr Arg Gly Ile Phe Glu Thr Lys
    770                 775                 780                 
Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg
785                 790                 795                 800 
Arg Ile Leu Gln Gln Leu Gly Leu Asp Ser Thr Cys Glu Asp Ser Ile
                805                 810                 815     
Val Val Lys Glu Val Cys Gly Ala Val Ser Arg Arg Ala Ala Gln Leu
            820                 825                 830         
Cys Gly Ala Gly Leu Ala Ala Ile Val Glu Lys Arg Arg Glu Asp Gln
        835                 840                 845             
Gly Leu Glu His Leu Arg Ile Thr Val Gly Val Asp Gly Thr Leu Tyr
    850                 855                 860                 
Lys Leu His Pro His Phe Ser Arg Ile Leu Gln Glu Thr Val Lys Glu
865                 870                 875                 880 
Leu Ala Pro Arg Cys Asp Val Thr Phe Met Leu Ser Glu Asp Gly Ser
                885                 890                 895     
Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Lys Arg Leu Gln Gln
            900                 905                 910         
Ala Gln Lys Glu Lys
        915         


<210> 7279
<211> 1087
<212> PRT
<213> Homo sapiens

<400> 7279
Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln
 1               5                  10                  15      
Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr
            20                  25                  30          
Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala
        35                  40                  45              
Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn
    50                  55                  60                  
Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn
65                  70                  75                  80  
Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp
                85                  90                  95      
Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly
            100                 105                 110         
Gln Thr Glu Ser Asn Glu Glu Gly Lys Glu Asn Arg Asp Arg Asp Arg
        115                 120                 125             
Asp Tyr Ser Arg Arg Arg Gly Gly Pro Pro Arg Arg Gly Arg Gly Ala
    130                 135                 140                 
Ser Arg Gly Arg Glu Phe Arg Gly Gln Glu Asn Gly Leu Asp Gly Thr
145                 150                 155                 160 
Lys Ser Gly Gly Pro Ser Gly Arg Gly Thr Glu Arg Gly Arg Arg Gly
                165                 170                 175     
Arg Gly Arg Gly Arg Gly Gly Ser Gly Arg Arg Gly Gly Arg Phe Ser
            180                 185                 190         
Ala Gln Gly Met Gly Thr Phe Asn Pro Ala Asp Tyr Ala Glu Pro Ala
        195                 200                 205             
Asn Thr Asp Asp Asn Tyr Gly Asn Ser Ser Gly Asn Thr Trp Asn Asn
    210                 215                 220                 
Thr Gly His Phe Glu Pro Asp Asp Gly Thr Ser Ala Trp Arg Thr Ala
225                 230                 235                 240 
Thr Glu Glu Trp Gly Thr Glu Asp Trp Asn Glu Asp Leu Ser Glu Thr
                245                 250                 255     
Lys Ile Phe Thr Ala Ser Asn Val Ser Ser Val Pro Leu Pro Ala Glu
            260                 265                 270         
Asn Val Thr Ile Thr Ala Gly Gln Arg Ile Asp Leu Ala Val Leu Leu
        275                 280                 285             
Gly Lys Thr Pro Ser Thr Met Glu Asn Asp Ser Ser Asn Leu Asp Pro
    290                 295                 300                 
Ser Gln Ala Pro Ser Leu Ala Gln Pro Leu Val Phe Ser Asn Ser Lys
305                 310                 315                 320 
Gln Thr Ala Ile Ser Gln Pro Ala Ser Gly Asn Thr Phe Ser His His
                325                 330                 335     
Ser Met Val Ser Met Leu Gly Lys Gly Phe Gly Asp Val Gly Glu Ala
            340                 345                 350         
Lys Gly Gly Ser Thr Thr Gly Ser Gln Phe Leu Glu Gln Phe Lys Thr
        355                 360                 365             
Ala Gln Ala Leu Ala Gln Leu Ala Ala Gln His Ser Gln Ser Gly Ser
    370                 375                 380                 
Thr Thr Thr Ser Ser Trp Asp Met Gly Ser Thr Thr Gln Ser Pro Ser
385                 390                 395                 400 
Leu Val Gln Tyr Asp Leu Lys Asn Pro Ser Asp Ser Ala Val His Ser
                405                 410                 415     
Pro Phe Thr Lys Arg Gln Ala Phe Thr Pro Ser Ser Thr Met Met Glu
            420                 425                 430         
Val Phe Leu Gln Glu Lys Ser Pro Ala Val Ala Thr Ser Thr Ala Ala
        435                 440                 445             
Pro Pro Pro Pro Ser Ser Pro Leu Pro Ser Lys Ser Thr Ser Ala Pro
    450                 455                 460                 
Gln Met Ser Pro Gly Ser Ser Asp Asn Gln Ser Ser Ser Pro Gln Pro
465                 470                 475                 480 
Ala His Gln Lys Leu Lys Gln Gln Lys Lys Lys Ala Ser Leu Thr Ser
                485                 490                 495     
Lys Ile Pro Ala Leu Ala Val Glu Met Pro Gly Ser Ala Asp Ile Ser
            500                 505                 510         
Gly Leu Asn Leu Gln Phe Gly Ala Leu Gln Phe Gly Ser Glu Pro Val
        515                 520                 525             
Leu Ser Asp Tyr Glu Ser Thr Pro Thr Thr Ser Ala Ser Ser Ser Gln
    530                 535                 540                 
Ala Pro Ser Ser Leu Tyr Thr Ser Thr Ala Ser Glu Ser Ser Ser Thr
545                 550                 555                 560 
Ile Ser Ser Asn Gln Ser Gln Glu Ser Gly Tyr Gln Ser Gly Pro Ile
                565                 570                 575     
Gln Ser Thr Thr Tyr Thr Ser Gln Asn Asn Ala Gln Gly Pro Leu Tyr
            580                 585                 590         
Glu Gln Arg Ser Thr Gln Thr Arg Arg Tyr Pro Ser Ser Ile Ser Ser
        595                 600                 605             
Ser Pro Gln Lys Asp Leu Thr Gln Ala Lys Asn Gly Phe Ser Ser Val
    610                 615                 620                 
Gln Ala Thr Gln Leu Gln Thr Thr Gln Ser Val Glu Gly Ala Thr Gly
625                 630                 635                 640 
Ser Ala Val Lys Ser Asp Ser Pro Ser Thr Ser Ser Ile Pro Pro Leu
                645                 650                 655     
Asn Glu Thr Val Ser Ala Ala Ser Leu Leu Thr Thr Thr Asn Gln His
            660                 665                 670         
Ser Ser Ser Leu Gly Gly Leu Ser His Ser Glu Glu Ile Pro Asn Thr
        675                 680                 685             
Thr Thr Thr Gln His Ser Ser Thr Leu Ser Thr Gln Gln Asn Thr Leu
    690                 695                 700                 
Ser Ser Ser Thr Ser Ser Gly Arg Thr Ser Thr Ser Thr Leu Leu His
705                 710                 715                 720 
Thr Ser Val Glu Ser Glu Ala Asn Leu His Ser Ser Ser Ser Thr Phe
                725                 730                 735     
Ser Thr Thr Ser Ser Thr Val Ser Ala Pro Pro Pro Val Val Ser Val
            740                 745                 750         
Ser Ser Ser Leu Asn Ser Gly Ser Ser Leu Gly Leu Ser Leu Gly Ser
        755                 760                 765             
Asn Ser Thr Val Thr Ala Ser Thr Arg Ser Ser Val Ala Thr Thr Ser
    770                 775                 780                 
Gly Lys Ala Pro Pro Asn Leu Pro Pro Gly Val Pro Pro Leu Leu Pro
785                 790                 795                 800 
Asn Pro Tyr Ile Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln
                805                 810                 815     
Val Tyr Gly Tyr Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu
            820                 825                 830         
Asp Tyr Tyr Ser Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly
        835                 840                 845             
Arg Asp Gly Ser Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys
    850                 855                 860                 
Phe Gly Arg Gly Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala
865                 870                 875                 880 
Gln Pro Gln Gln Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr
                885                 890                 895     
Phe Leu Asn Pro Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro
            900                 905                 910         
Tyr Tyr Thr Gly Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro
        915                 920                 925             
Ala Val Phe Pro Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn
    930                 935                 940                 
Val Ser Val Asn Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr
945                 950                 955                 960 
Gly Ser His Gly Tyr Asn Thr Gly Val Ser Val Thr Ser Ser Asn Thr
                965                 970                 975     
Gly Val Pro Asp Ile Ser Gly Ser Val Tyr Ser Lys Thr Gln Gln Ser
            980                 985                 990         
Phe Glu Lys Gln Gly Phe His Ser Gly Thr Pro Ala Ala Ser Phe Asn
        995                 1000                1005            
Leu Pro Ser Ala Leu Gly Ser Gly Gly Pro Ile Asn Pro Ala Thr Ala
    1010                1015                1020                
Ala Ala Tyr Pro Pro Ala Pro Phe Met His Ile Leu Thr Pro His Gln
1025                1030                1035                1040
Gln Pro His Ser Gln Ile Leu His His His Leu Gln Gln Asp Gly Gln
                1045                1050                1055    
Thr Gly Ser Gly Gln Arg Ser Gln Thr Ser Ser Ile Pro Gln Lys Pro
            1060                1065                1070        
Gln Thr Asn Lys Ser Ala Tyr Asn Ser Tyr Ser Trp Gly Ala Asn
        1075                1080                1085        


<210> 7280
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 7280
Met Lys Arg Ser Glu Lys Pro Glu Gly Tyr Arg Gln Met Arg Pro Lys
 1               5                  10                  15      
Thr Phe Pro Ala Ser Asn Tyr Thr Val Ser Ser Arg Gln Met Leu Gln
            20                  25                  30          
Glu Ile Arg Glu Ser Leu Arg Asn Leu Ser Lys Pro Ser Asp Ala Ala
        35                  40                  45              
Lys Ala Glu His Asn Met Ser Lys Met Ser Thr Glu Asp Pro Arg Gln
    50                  55                  60                  
Val Arg Asn Pro Pro Lys Phe Gly Thr His His Lys Ala Leu Gln Glu
65                  70                  75                  80  
Ile Arg Asn Ser Leu Leu Pro Phe Ala Asn Glu Thr Asn Ser Ser Arg
                85                  90                  95      
Ser Thr Ser Glu Val Asn Pro Gln Met Leu Gln Asp Leu Gln Ala Ala
            100                 105                 110         
Gly Phe Asp Glu Asp Met Val Ile Gln Ala Leu Gln Lys Thr Asn Asn
        115                 120                 125             
Arg Ser Ile Glu Ala Ala Ile Glu Phe Ile Ser Lys Met Ser Tyr Gln
    130                 135                 140                 
Asp Pro Arg Arg Glu Gln Met Ala Ala Ala Ala Ala Arg Pro Ile Asn
145                 150                 155                 160 
Ala Ser Met Lys Pro Gly Asn Val Gln Gln Ser Val Asn Arg Lys Gln
                165                 170                 175     
Ser Trp Lys Gly Ser Lys Glu Ser Leu Val Pro Gln Arg His Gly Pro
            180                 185                 190         
Pro Leu Gly Glu Ser Val Ala Tyr His Ser Glu Ser Pro Asn Ser Gln
        195                 200                 205             
Thr Asp Val Gly Arg Pro Leu Ser Gly Ser Gly Ile Ser Ala Phe Val
    210                 215                 220                 
Gln Ala His Pro Ser Asn Gly Gln Arg Val Asn Pro Pro Pro Pro Pro
225                 230                 235                 240 
Gln Val Arg Ser Val Thr Pro Pro Pro Pro Pro Arg Gly Gln Thr Pro
                245                 250                 255     
Pro Pro Arg Gly Thr Thr Pro Pro Pro Pro Ser Trp Glu Pro Asn Ser
            260                 265                 270         
Gln Thr Lys Arg Tyr Ser Gly Asn Met Glu Tyr Val Ile Ser Arg Ile
        275                 280                 285             
Ser Pro Val Pro Pro Gly Ala Trp Gln Glu Gly Tyr Pro Pro Pro Pro
    290                 295                 300                 
Leu Asn Thr Ser Pro Met Asn Pro Pro Asn Gln Gly Gln Arg Gly Ile
305                 310                 315                 320 
Ser Ser Val Pro Val Gly Arg Gln Pro Ile Ile Met Gln Ser Ser Ser
                325                 330                 335     
Lys Phe Asn Phe Pro Ser Gly Arg Pro Gly Met Gln Asn Gly Thr Gly
            340                 345                 350         
Gln Thr Asp Phe Met Ile His Gln Asn Val Val Pro Ala Gly Thr Val
        355                 360                 365             
Asn Arg Gln Pro Pro Pro Pro Tyr Pro Leu Thr Ala Ala Asn Gly Gln
    370                 375                 380                 
Ser Pro Ser Ala Leu Gln Thr Gly Gly Ser Ala Ala Pro Ser Ser Tyr
385                 390                 395                 400 
Thr Asn Gly Ser Ile Pro Gln Ser Met Met Val Pro Asn Arg Asn Ser
                405                 410                 415     
His Asn Met Glu Leu Tyr Asn Ile Ser Val Pro Gly Leu Gln Thr Asn
            420                 425                 430         
Trp Pro Gln Ser Ser Ser Ala Pro Ala Gln Ser Ser Pro Ser Ser Gly
        435                 440                 445             
His Glu Ile Pro Thr Trp Gln Pro Asn Ile Pro Val Arg Ser Asn Ser
    450                 455                 460                 
Phe Asn Asn Pro Leu Gly Asn Arg Ala Ser His Ser Ala Asn Ser Gln
465                 470                 475                 480 
Pro Ser Ala Thr Thr Val Thr Ala Ile Thr Pro Ala Pro Ile Gln Gln
                485                 490                 495     
Pro Val Lys Ser Met Arg Val Leu Lys Pro Glu Leu Gln Thr Ala Leu
            500                 505                 510         
Ala Pro Thr His Pro Ser Trp Ile Pro Gln Pro Ile Gln Thr Val Gln
        515                 520                 525             
Pro Ser Pro Phe Pro Glu Gly Thr Ala Ser Asn Val Thr Val Met Pro
    530                 535                 540                 
Pro Val Ala Glu Ala Pro Asn Tyr Gln Gly Pro Pro Pro Pro Tyr Pro
545                 550                 555                 560 
Lys His Leu Leu His Gln Asn Pro Ser Val Pro Pro Tyr Glu Ser Ile
                565                 570                 575     
Ser Lys Pro Ser Lys Glu Asp Gln Pro Ser Leu Pro Lys Glu Asp Glu
            580                 585                 590         
Ser Glu Lys Ser Tyr Glu Asn Val Asp Ser Gly Asp Lys Glu Lys Lys
        595                 600                 605             
Gln Ile Thr Thr Ser Pro Ile Thr Val Arg Lys Asn Lys Lys Asp Glu
    610                 615                 620                 
Glu Arg Arg Glu Ser Arg Ile Gln Ser Tyr Ser Pro Gln Ala Phe Lys
625                 630                 635                 640 
Phe Phe Met Glu Gln His Val Glu Asn Val Leu Lys Ser His Gln Gln
                645                 650                 655     
Arg Leu His Arg Lys Lys Gln Leu Glu Asn Glu Met Met Arg Val Gly
            660                 665                 670         
Leu Ser Gln Asp Ala Gln Asp Gln Met Arg Lys Met Leu Cys Gln Lys
        675                 680                 685             
Glu Ser Asn Tyr Ile Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met
    690                 695                 700                 
Phe Val Lys Ile Lys Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys
705                 710                 715                 720 
Leu Ala Arg Lys Val Asp Thr Lys Ala Leu Tyr Ala Thr Lys Thr Leu
                725                 730                 735     
Arg Lys Lys Asp Val Leu Leu Arg Asn Gln Val Ala His Val Lys Ala
            740                 745                 750         
Glu Arg Asp Ile Leu Ala Glu Ala Asp Asn Glu Trp Val Val Arg Leu
        755                 760                 765             
Tyr Tyr Ser Phe Gln Asp Lys Asp Asn Leu Tyr Phe Val Met Asp Tyr
    770                 775                 780                 
Ile Pro Gly Gly Asp Met Met Ser Leu Leu Ile Arg Met Gly Ile Phe
785                 790                 795                 800 
Pro Glu Ser Leu Ala Arg Phe Tyr Ile Ala Glu Leu Thr Cys Ala Val
                805                 810                 815     
Glu Ser Val His Lys Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp
            820                 825                 830         
Asn Ile Leu Ile Asp Arg Asp Gly His Ile Lys Leu Thr Asp Phe Gly
        835                 840                 845             
Leu Cys Thr Gly Phe Arg Trp Thr His Asp Ser Lys Tyr Tyr Gln Ser
    850                 855                 860                 
Gly Asp His Pro Arg Gln Asp Ser Met Asp Phe Ser Asn Glu Trp Gly
865                 870                 875                 880 
Asp Pro Ser Ser Cys Arg Cys Gly Asp Arg Leu Lys Pro Leu Glu Arg
                885                 890                 895     
Arg Ala Ala Arg Gln His Gln Arg Cys Leu Ala His Ser Leu Val Gly
            900                 905                 910         
Thr Pro Asn Tyr Ile Ala Pro Glu Val Leu Leu Arg Thr Gly Tyr Thr
        915                 920                 925             
Gln Leu Cys Asp Trp Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu
    930                 935                 940                 
Val Gly Gln Pro Pro Phe Leu Ala Gln Thr Pro Leu Glu Thr Gln Met
945                 950                 955                 960 
Lys Val Ile Asn Trp Gln Thr Ser Leu His Ile Pro Pro Gln Ala Lys
                965                 970                 975     
Leu Ser Pro Glu Ala Ser Asp Leu Ile Ile Lys Leu Cys Arg Gly Pro
            980                 985                 990         
Glu Asp Arg Leu Gly Lys Asn Gly Ala Asp Glu Ile Lys Ala His Pro
        995                 1000                1005            
Phe Phe Lys Thr Ile Asp Phe Ser Ser Asp Leu Arg Gln Gln Ser Ala
    1010                1015                1020                
Ser Tyr Ile Pro Lys Ile Thr His Pro Thr Asp Thr Ser Asn Phe Asp
1025                1030                1035                1040
Pro Val Asp Pro Asp Lys Leu Trp Ser Asp Asp Asn Glu Glu Glu Asn
                1045                1050                1055    
Val Asn Asp Thr Leu Asn Gly Trp Tyr Lys Asn Gly Lys His Pro Glu
            1060                1065                1070        
His Ala Phe Tyr Glu Phe Thr Phe Arg Arg Phe Phe Asp Asp Asn Gly
        1075                1080                1085            
Tyr Pro Tyr Asn Tyr Pro Lys Pro Ile Glu Tyr Glu Tyr Ile Asn Ser
    1090                1095                1100                
Gln Gly Ser Glu Gln Gln Ser Asp Glu Asp Asp Gln Asn Thr Gly Ser
1105                1110                1115                1120
Glu Ile Lys Asn Arg Asp Leu Val Tyr Val
                1125                1130


<210> 7281
<211> 218
<212> PRT
<213> Homo sapiens

<400> 7281
Met Gly Pro Leu Ser Ser Gln Arg Arg Val Met Gly Ile Ser Gln Asp
 1               5                  10                  15      
Asn Trp His Lys Arg Arg Lys Thr Gly Ser Lys Arg Lys Pro Tyr Asp
            20                  25                  30          
Lys Lys Arg Lys Tyr Glu Leu Gly His Leu Ala Ala Asn Thr Lys Ile
        35                  40                  45              
Gly Pro His His Ile His Thr Val Arg Val Arg Gly Gly Asn Asn Lys
    50                  55                  60                  
Tyr Gly Ala Leu Arg Arg Asp Met Gly Asn Phe Ser Trp Gly Ser Glu
65                  70                  75                  80  
Cys Cys Thr Arg Lys Thr Arg Ile Thr Asp Val Val Tyr Asp Ala Pro
                85                  90                  95      
Asn Ser Lys Leu Val Arg Thr Lys Thr Leu Val Glu Asn Cys Phe Val
            100                 105                 110         
Leu Thr Asp Ser Thr Pro Tyr His Gln Trp Tyr Glu Ser His Tyr Ala
        115                 120                 125             
Leu Pro Leu Gly Cys Lys Lys Gly Ala Lys Leu Thr Pro Glu Glu Glu
    130                 135                 140                 
Lys Thr Leu Asn Lys Lys Arg Ser Lys Lys Ile Gln Lys Lys Tyr Asp
145                 150                 155                 160 
Glu Arg Glu Lys Asn Ala Lys Ile Ser Arg Leu Leu Gly Glu Gln Phe
                165                 170                 175     
Gln Gln Gly Lys Leu Leu Ala Cys Val Ala Ser Arg Leu Gly Gln Cys
            180                 185                 190         
Gly Gln Ala His Val Tyr Val Pro Gly Gly Lys Glu Met Glu Phe Tyr
        195                 200                 205             
Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys
    210                 215             


<210> 7282
<211> 485
<212> PRT
<213> Homo sapiens

<400> 7282
Met Ala Ala Ala Pro Pro Leu Ser Lys Ala Glu Tyr Leu Lys Arg Tyr
 1               5                  10                  15      
Leu Ser Gly Ala Asp Ala Gly Val Asp Arg Gly Ser Glu Ser Gly Arg
            20                  25                  30          
Lys Arg Arg Lys Lys Arg Pro Lys Pro Gly Gly Ala Gly Gly Lys Gly
        35                  40                  45              
Met Arg Ile Val Asp Asp Asp Val Ser Trp Thr Ala Ile Ser Thr Thr
    50                  55                  60                  
Lys Leu Glu Lys Glu Glu Glu Glu Asp Asp Gly Asp Leu Pro Val Val
65                  70                  75                  80  
Ala Glu Phe Val Asp Glu Arg Pro Glu Glu Val Lys Gln Met Glu Ala
                85                  90                  95      
Phe Arg Ser Ser Ala Lys Trp Lys Leu Leu Gly Gly His Asn Glu Asp
            100                 105                 110         
Leu Pro Ser Asn Arg His Phe Arg His Asp Thr Pro Asp Ser Ser Pro
        115                 120                 125             
Arg Arg Val Arg His Gly Thr Pro Asp Pro Ser Pro Arg Lys Asp Arg
    130                 135                 140                 
His Asp Thr Pro Asp Pro Ser Pro Arg Arg Ala Arg His Asp Thr Pro
145                 150                 155                 160 
Asp Pro Ser Pro Leu Arg Gly Ala Arg His Asp Ser Asp Thr Ser Pro
                165                 170                 175     
Pro Arg Arg Ile Arg His Asp Ser Ser Asp Thr Ser Pro Pro Arg Arg
            180                 185                 190         
Ala Arg His Asp Ser Pro Asp Pro Ser Pro Pro Arg Arg Pro Gln His
        195                 200                 205             
Asn Ser Ser Gly Asp Cys Gln Lys Ala Thr Asp Ser Asp Leu Ser Ser
    210                 215                 220                 
Pro Arg His Lys Gln Ser Pro Gly His Gln Asp Ser Asp Ser Asp Leu
225                 230                 235                 240 
Ser Pro Pro Arg Asn Arg Pro Arg His Arg Ser Ser Asp Ser Asp Leu
                245                 250                 255     
Ser Pro Pro Arg Arg Arg Gln Arg Thr Lys Ser Ser Asp Ser Asp Leu
            260                 265                 270         
Ser Pro Pro Arg Arg Ser Gln Pro Pro Gly Lys Lys Ala Ala His Met
        275                 280                 285             
Tyr Ser Gly Ala Lys Thr Gly Leu Val Leu Thr Asp Ile Gln Arg Glu
    290                 295                 300                 
Gln Gln Glu Leu Lys Glu Gln Asp Gln Glu Thr Met Ala Phe Glu Ala
305                 310                 315                 320 
Glu Phe Gln Tyr Ala Glu Thr Val Phe Arg Asp Lys Ser Gly Arg Lys
                325                 330                 335     
Arg Asn Leu Lys Leu Glu Arg Leu Glu Gln Arg Arg Lys Ala Glu Lys
            340                 345                 350         
Asp Ser Glu Arg Asp Glu Leu Tyr Ala Gln Trp Gly Lys Gly Leu Ala
        355                 360                 365             
Gln Ser Arg Gln Gln Gln Gln Asn Val Glu Asp Ala Met Lys Glu Met
    370                 375                 380                 
Gln Lys Pro Leu Ala Arg Tyr Ile Asp Asp Glu Asp Leu Asp Arg Met
385                 390                 395                 400 
Leu Arg Glu Gln Glu Arg Glu Gly Asp Pro Met Ala Asn Phe Ile Lys
                405                 410                 415     
Lys Asn Lys Ala Lys Glu Asn Lys Asn Lys Lys Val Arg Pro Arg Tyr
            420                 425                 430         
Ser Gly Pro Ala Pro Pro Pro Asn Arg Phe Asn Ile Trp Pro Gly Tyr
        435                 440                 445             
Arg Trp Asp Gly Val Asp Arg Ser Asn Gly Phe Glu Gln Lys Arg Phe
    450                 455                 460                 
Ala Arg Leu Ala Ser Lys Lys Ala Val Glu Glu Leu Ala Tyr Lys Trp
465                 470                 475                 480 
Ser Val Glu Asp Met
                485 


<210> 7283
<211> 619
<212> PRT
<213> Homo sapiens

<400> 7283
Met Ala Ala Ala Pro Pro Leu Ser Lys Ala Glu Tyr Leu Lys Arg Tyr
 1               5                  10                  15      
Leu Ser Gly Ala Asp Ala Gly Val Asp Arg Gly Ser Glu Ser Gly Arg
            20                  25                  30          
Lys Arg Arg Lys Lys Arg Pro Lys Pro Gly Gly Ala Gly Gly Lys Gly
        35                  40                  45              
Met Arg Ile Val Asp Asp Asp Val Ser Trp Thr Ala Ile Ser Thr Thr
    50                  55                  60                  
Lys Leu Glu Lys Glu Glu Glu Glu Asp Asp Gly Asp Leu Pro Val Val
65                  70                  75                  80  
Ala Glu Phe Val Asp Glu Arg Pro Glu Glu Val Lys Gln Met Glu Ala
                85                  90                  95      
Phe Arg Ser Ser Ala Lys Trp Lys Leu Leu Gly Gly His Asn Glu Asp
            100                 105                 110         
Leu Pro Ser Asn Arg His Phe Arg His Asp Thr Pro Asp Ser Ser Pro
        115                 120                 125             
Arg Arg Val Arg His Gly Thr Pro Asp Pro Ser Pro Arg Lys Asp Arg
    130                 135                 140                 
His Asp Thr Pro Asp Pro Ser Pro Arg Arg Ala Arg His Asp Thr Pro
145                 150                 155                 160 
Asp Pro Ser Pro Leu Arg Gly Ala Arg His Asp Ser Asp Thr Ser Pro
                165                 170                 175     
Pro Arg Arg Ile Arg His Asp Ser Ser Asp Thr Ser Pro Pro Arg Arg
            180                 185                 190         
Ala Arg His Asp Ser Pro Asp Pro Ser Pro Pro Arg Arg Pro Gln His
        195                 200                 205             
Asn Ser Ser Gly Ala Ser Pro Arg Arg Val Arg His Asp Ser Pro Asp
    210                 215                 220                 
Pro Ser Pro Pro Arg Arg Ala Arg His Gly Ser Ser Asp Ile Ser Ser
225                 230                 235                 240 
Pro Arg Arg Val His Asn Asn Ser Pro Asp Thr Ser Arg Arg Thr Leu
                245                 250                 255     
Gly Ser Ser Asp Thr Gln Gln Leu Arg Arg Ala Arg His Asp Ser Pro
            260                 265                 270         
Asp Leu Ala Pro Asn Val Thr Tyr Ser Leu Pro Arg Thr Lys Ser Gly
        275                 280                 285             
Lys Ala Pro Glu Arg Ala Ser Ser Lys Thr Ser Pro His Trp Lys Glu
    290                 295                 300                 
Ser Gly Ala Ser His Leu Ser Phe Pro Lys Asn Ser Lys Tyr Glu Tyr
305                 310                 315                 320 
Asp Pro Asp Ile Ser Pro Pro Arg Lys Lys Gln Ala Lys Ser His Phe
                325                 330                 335     
Gly Asp Lys Lys Gln Leu Asp Ser Lys Gly Asp Cys Gln Lys Ala Thr
            340                 345                 350         
Asp Ser Asp Leu Ser Ser Pro Arg His Lys Gln Ser Pro Gly His Gln
        355                 360                 365             
Asp Ser Asp Ser Asp Leu Ser Pro Pro Arg Asn Arg Pro Arg His Arg
    370                 375                 380                 
Ser Ser Asp Ser Asp Leu Ser Pro Pro Arg Arg Arg Gln Arg Thr Lys
385                 390                 395                 400 
Ser Ser Asp Ser Asp Leu Ser Pro Pro Arg Arg Ser Gln Pro Pro Gly
                405                 410                 415     
Lys Lys Ala Ala His Met Tyr Ser Gly Ala Lys Thr Gly Leu Val Leu
            420                 425                 430         
Thr Asp Ile Gln Arg Glu Gln Gln Glu Leu Lys Glu Gln Asp Gln Glu
        435                 440                 445             
Thr Met Ala Phe Glu Ala Glu Phe Gln Tyr Ala Glu Thr Val Phe Arg
    450                 455                 460                 
Asp Lys Ser Gly Arg Lys Arg Asn Leu Lys Leu Glu Arg Leu Glu Gln
465                 470                 475                 480 
Arg Arg Lys Ala Glu Lys Asp Ser Glu Arg Asp Glu Leu Tyr Ala Gln
                485                 490                 495     
Trp Gly Lys Gly Leu Ala Gln Ser Arg Gln Gln Gln Gln Asn Val Glu
            500                 505                 510         
Asp Ala Met Lys Glu Met Gln Lys Pro Leu Ala Arg Tyr Ile Asp Asp
        515                 520                 525             
Glu Asp Leu Asp Arg Met Leu Arg Glu Gln Glu Arg Glu Gly Asp Pro
    530                 535                 540                 
Met Ala Asn Phe Ile Lys Lys Asn Lys Ala Lys Glu Asn Lys Asn Lys
545                 550                 555                 560 
Lys Val Arg Pro Arg Tyr Ser Gly Pro Ala Pro Pro Pro Asn Arg Phe
                565                 570                 575     
Asn Ile Trp Pro Gly Tyr Arg Trp Asp Gly Val Asp Arg Ser Asn Gly
            580                 585                 590         
Phe Glu Gln Lys Arg Phe Ala Arg Leu Ala Ser Lys Lys Ala Val Glu
        595                 600                 605             
Glu Leu Ala Tyr Lys Trp Ser Val Glu Asp Met
    610                 615                 


<210> 7284
<211> 764
<212> PRT
<213> Homo sapiens

<400> 7284
Met Glu Glu Ser Ser Ser Val Ala Met Leu Val Pro Asp Ile Gly Glu
 1               5                  10                  15      
Gln Glu Ala Ile Leu Thr Ala Glu Ser Ile Ile Ser Pro Ser Leu Glu
            20                  25                  30          
Ile Asp Glu Gln Arg Lys Thr Lys Pro Asp Pro Leu Ile His Val Ile
        35                  40                  45              
Gln Lys Leu Ser Lys Ile Val Glu Asn Glu Lys Ser Gln Lys Cys Leu
    50                  55                  60                  
Leu Ile Gly Lys Lys Arg Pro Arg Ser Ser Ala Ala Thr His Ser Leu
65                  70                  75                  80  
Glu Thr Gln Glu Leu Cys Glu Ile Pro Ala Lys Val Ile Gln Ser Pro
                85                  90                  95      
Ala Ala Asp Thr Arg Arg Ala Glu Met Ser Gln Thr Asn Phe Thr Pro
            100                 105                 110         
Asp Thr Leu Ala Gln Asn Glu Gly Lys Ala Met Ser Tyr Gln Cys Ser
        115                 120                 125             
Leu Cys Lys Phe Leu Ser Ser Ser Phe Ser Val Leu Lys Asp His Ile
    130                 135                 140                 
Lys Gln His Gly Gln Gln Asn Glu Val Ile Leu Met Cys Ser Glu Cys
145                 150                 155                 160 
His Ile Thr Ser Arg Ser Gln Glu Glu Leu Glu Ala His Val Val Asn
                165                 170                 175     
Asp His Asp Asn Asp Ala Asn Ile His Thr Gln Ser Lys Ala Gln Gln
            180                 185                 190         
Cys Val Ser Pro Ser Ser Ser Leu Cys Arg Lys Thr Thr Glu Arg Asn
        195                 200                 205             
Glu Thr Ile Pro Asp Ile Pro Val Ser Val Asp Asn Leu Gln Thr His
    210                 215                 220                 
Thr Val Gln Thr Ala Ser Val Ala Glu Met Gly Arg Arg Lys Trp Tyr
225                 230                 235                 240 
Ala Tyr Glu Gln Tyr Gly Met Tyr Arg Cys Leu Phe Cys Ser Tyr Thr
                245                 250                 255     
Cys Gly Gln Gln Arg Met Leu Lys Thr His Ala Trp Lys His Ala Gly
            260                 265                 270         
Glu Val Asp Cys Ser Tyr Pro Ile Phe Glu Asn Glu Asn Glu Pro Leu
        275                 280                 285             
Gly Leu Leu Asp Ser Ser Ala Ala Ala Ala Pro Gly Gly Val Asp Ala
    290                 295                 300                 
Val Val Ile Ala Ile Gly Glu Ser Glu Leu Ser Ile His Asn Gly Pro
305                 310                 315                 320 
Ser Val Gln Val Gln Ile Cys Ser Ser Glu Gln Leu Ser Ser Ser Ser
                325                 330                 335     
Pro Leu Glu Gln Ser Ala Glu Arg Gly Val His Leu Ser Gln Ser Val
            340                 345                 350         
Thr Leu Asp Pro Asn Glu Glu Glu Met Leu Glu Val Ile Ser Asp Ala
        355                 360                 365             
Glu Glu Asn Leu Ile Pro Asp Ser Leu Leu Thr Ser Ala Gln Lys Ile
    370                 375                 380                 
Ile Ser Ser Ser Pro Asn Lys Lys Gly His Val Asn Val Ile Val Glu
385                 390                 395                 400 
Arg Leu Pro Ser Ala Glu Glu Thr Leu Ser Gln Lys Arg Phe Leu Met
                405                 410                 415     
Asn Thr Glu Met Glu Glu Gly Lys Asp Leu Ser Leu Thr Glu Ala Gln
            420                 425                 430         
Ile Gly Arg Glu Gly Met Asp Asp Val Tyr Arg Ala Asp Lys Cys Thr
        435                 440                 445             
Val Asp Ile Gly Gly Leu Ile Ile Gly Trp Ser Ser Ser Glu Lys Lys
    450                 455                 460                 
Asp Glu Leu Met Asn Lys Gly Leu Ala Thr Asp Glu Asn Ala Pro Pro
465                 470                 475                 480 
Gly Arg Arg Arg Thr Asn Ser Glu Ser Leu Arg Leu His Ser Leu Ala
                485                 490                 495     
Ala Glu Ala Leu Val Thr Met Pro Ile Arg Ala Ala Glu Leu Thr Arg
            500                 505                 510         
Ala Asn Leu Gly His Tyr Gly Asp Ile Asn Leu Leu Asp Pro Asp Thr
        515                 520                 525             
Ser Gln Arg Gln Val Asp Ser Thr Leu Ala Ala Tyr Ser Lys Met Met
    530                 535                 540                 
Ser Pro Leu Lys Asn Ser Ser Asp Gly Leu Thr Ser Leu Asn Gln Ser
545                 550                 555                 560 
Asn Ser Thr Leu Val Ala Leu Pro Glu Gly Arg Gln Glu Leu Ser Asp
                565                 570                 575     
Gly Gln Val Lys Thr Gly Ile Ser Met Ser Leu Leu Thr Val Ile Glu
            580                 585                 590         
Lys Leu Arg Glu Arg Thr Asp Gln Asn Ala Ser Asp Asp Asp Ile Leu
        595                 600                 605             
Lys Glu Leu Gln Asp Asn Ala Gln Cys Gln Pro Asn Ser Asp Thr Ser
    610                 615                 620                 
Leu Ser Gly Asn Asn Val Val Glu Tyr Ile Pro Asn Ala Glu Arg Pro
625                 630                 635                 640 
Tyr Arg Cys Arg Leu Cys His Tyr Thr Ser Gly Asn Lys Gly Tyr Ile
                645                 650                 655     
Lys Gln His Leu Arg Val His Arg Gln Arg Gln Pro Tyr Gln Cys Pro
            660                 665                 670         
Ile Cys Glu His Ile Ala Asp Asn Ser Lys Asp Leu Glu Ser His Met
        675                 680                 685             
Ile His His Cys Lys Thr Arg Ile Tyr Gln Cys Lys Gln Cys Glu Glu
    690                 695                 700                 
Ser Phe His Tyr Lys Ser Gln Leu Arg Asn His Glu Arg Glu Gln His
705                 710                 715                 720 
Ser Leu Pro Asp Thr Leu Ser Ile Ala Thr Ser Asn Glu Pro Arg Ile
                725                 730                 735     
Ser Ser Asp Thr Ala Asp Gly Lys Cys Val Gln Glu Gly Ile Tyr Val
            740                 745                 750         
Phe Cys Tyr Ala Gly Cys Ser Asp Leu His Met Thr
        755                 760                 


<210> 7285
<211> 989
<212> PRT
<213> Homo sapiens

<400> 7285
Ser Phe Gly Arg Leu Asn Ala Leu Asn Met Lys Ser Leu Lys Ala Lys
 1               5                  10                  15      
Phe Arg Lys Ser Asp Thr Asn Glu Trp Asn Lys Asn Asp Asp Arg Leu
            20                  25                  30          
Leu Gln Ala Val Glu Asn Gly Asp Ala Glu Lys Val Ala Ser Leu Leu
        35                  40                  45              
Gly Lys Lys Gly Ala Ser Ala Thr Lys His Asp Ser Glu Gly Lys Thr
    50                  55                  60                  
Ala Phe His Leu Ala Ala Ala Lys Gly His Val Glu Cys Leu Arg Val
65                  70                  75                  80  
Met Ile Thr His Gly Val Asp Val Thr Ala Gln Asp Thr Thr Gly His
                85                  90                  95      
Ser Ala Leu His Leu Ala Ala Lys Asn Ser His His Glu Cys Ile Arg
            100                 105                 110         
Lys Leu Leu Gln Ser Lys Cys Pro Ala Glu Ser Val Asp Ser Ser Gly
        115                 120                 125             
Lys Thr Ala Leu His Tyr Ala Ala Ala Gln Gly Cys Leu Gln Ala Val
    130                 135                 140                 
Gln Ile Leu Cys Glu His Lys Ser Pro Ile Asn Leu Lys Asp Leu Asp
145                 150                 155                 160 
Gly Asn Ile Pro Leu Leu Leu Ala Val Gln Asn Gly His Ser Glu Ile
                165                 170                 175     
Cys His Phe Leu Leu Asp His Gly Ala Asp Val Asn Ser Arg Asn Lys
            180                 185                 190         
Ser Gly Arg Thr Ala Leu Met Leu Ala Cys Glu Ile Gly Ser Ser Asn
        195                 200                 205             
Ala Val Glu Ala Leu Ile Lys Lys Gly Ala Asp Leu Asn Leu Val Asp
    210                 215                 220                 
Ser Leu Gly Tyr Asn Ala Leu His Tyr Ser Lys Leu Ser Glu Asn Ala
225                 230                 235                 240 
Gly Ile Gln Ser Leu Leu Leu Ser Lys Ile Ser Gln Asp Ala Asp Leu
                245                 250                 255     
Lys Thr Pro Thr Lys Pro Lys Gln His Asp Gln Val Ser Lys Ile Ser
            260                 265                 270         
Ser Glu Arg Ser Gly Thr Pro Lys Lys Arg Lys Ala Pro Pro Pro Pro
        275                 280                 285             
Ile Ser Pro Thr Gln Leu Ser Asp Val Ser Ser Pro Arg Ser Ile Thr
    290                 295                 300                 
Ser Thr Pro Leu Ser Gly Lys Glu Ser Val Phe Phe Ala Glu Pro Pro
305                 310                 315                 320 
Phe Lys Ala Glu Ile Ser Ser Ile Arg Glu Asn Lys Asp Arg Leu Ser
                325                 330                 335     
Asp Ser Thr Thr Gly Ala Asp Ser Leu Leu Asp Ile Ser Ser Glu Ala
            340                 345                 350         
Asp Gln Gln Asp Leu Leu Ser Leu Leu Gln Ala Lys Val Ala Ser Leu
        355                 360                 365             
Thr Leu His Asn Lys Glu Leu Gln Asp Lys Leu Gln Ala Lys Ser Pro
    370                 375                 380                 
Lys Glu Ala Glu Ala Asp Leu Ser Phe Asp Ser Tyr His Ser Thr Gln
385                 390                 395                 400 
Thr Asp Leu Gly Pro Ser Leu Gly Lys Pro Gly Glu Thr Ser Pro Pro
                405                 410                 415     
Asp Ser Lys Ser Ser Pro Ser Val Leu Ile His Ser Leu Gly Lys Ser
            420                 425                 430         
Thr Thr Asp Asn Asp Val Arg Ile Gln Gln Leu Gln Glu Ile Leu Gln
        435                 440                 445             
Asp Leu Gln Lys Arg Leu Glu Ser Ser Glu Ala Glu Arg Lys Gln Leu
    450                 455                 460                 
Gln Val Glu Leu Gln Ser Arg Arg Ala Glu Leu Val Cys Leu Asn Asn
465                 470                 475                 480 
Thr Glu Ile Ser Glu Asn Ser Ser Asp Leu Ser Gln Lys Leu Lys Glu
                485                 490                 495     
Thr Gln Ser Lys Tyr Glu Glu Ala Met Lys Glu Val Leu Ser Val Gln
            500                 505                 510         
Lys Gln Met Lys Leu Gly Leu Val Ser Pro Glu Ser Met Asp Asn Tyr
        515                 520                 525             
Ser His Phe His Glu Leu Arg Val Thr Glu Glu Glu Ile Asn Val Leu
    530                 535                 540                 
Lys Gln Asp Leu Gln Asn Ala Leu Glu Glu Ser Glu Arg Asn Lys Glu
545                 550                 555                 560 
Lys Val Arg Glu Leu Glu Glu Lys Leu Val Glu Arg Glu Lys Gly Thr
                565                 570                 575     
Val Ile Lys Pro Pro Val Glu Glu Tyr Glu Glu Met Lys Ser Ser Tyr
            580                 585                 590         
Cys Ser Val Ile Glu Asn Met Asn Lys Glu Lys Ala Phe Leu Phe Glu
        595                 600                 605             
Lys Tyr Gln Glu Ala Gln Glu Glu Ile Met Lys Leu Lys Asp Thr Leu
    610                 615                 620                 
Lys Ser Gln Met Thr Gln Glu Ala Ser Asp Glu Ala Glu Asp Met Lys
625                 630                 635                 640 
Glu Ala Met Asn Arg Met Ile Asp Glu Leu Asn Lys Gln Val Ser Glu
                645                 650                 655     
Leu Ser Gln Leu Tyr Lys Glu Ala Gln Ala Glu Leu Glu Asp Tyr Arg
            660                 665                 670         
Lys Arg Lys Ser Leu Glu Asp Val Thr Ala Glu Tyr Ile His Lys Ala
        675                 680                 685             
Glu His Glu Lys Leu Met Gln Leu Thr Asn Val Ser Arg Ala Lys Ala
    690                 695                 700                 
Glu Asp Ala Leu Ser Glu Met Lys Ser Gln Tyr Ser Lys Val Leu Asn
705                 710                 715                 720 
Glu Leu Thr Gln Leu Lys Gln Leu Val Asp Ala Gln Lys Glu Asn Ser
                725                 730                 735     
Val Ser Ile Thr Glu His Leu Gln Val Ile Thr Thr Leu Arg Thr Ala
            740                 745                 750         
Ala Lys Glu Met Glu Glu Lys Ile Ser Asn Leu Lys Glu His Leu Ala
        755                 760                 765             
Ser Lys Glu Val Glu Val Ala Lys Leu Glu Lys Gln Leu Leu Glu Glu
    770                 775                 780                 
Lys Ala Ala Met Thr Asp Ala Met Val Pro Arg Ser Ser Tyr Glu Lys
785                 790                 795                 800 
Leu Gln Ser Ser Leu Glu Ser Glu Val Ser Val Leu Ala Ser Lys Leu
                805                 810                 815     
Lys Glu Ser Val Lys Glu Lys Glu Lys Val His Ser Glu Val Val Gln
            820                 825                 830         
Ile Arg Ser Glu Val Ser Gln Val Lys Arg Glu Lys Glu Asn Ile Gln
        835                 840                 845             
Thr Leu Leu Lys Ser Lys Glu Gln Glu Val Asn Glu Leu Leu Gln Lys
    850                 855                 860                 
Phe Gln Gln Ala Gln Glu Glu Leu Ala Glu Met Lys Arg Tyr Ser Glu
865                 870                 875                 880 
Ser Ser Ser Lys Leu Glu Glu Asp Lys Asp Lys Lys Ile Asn Glu Met
                885                 890                 895     
Ser Lys Glu Val Thr Lys Leu Lys Glu Ala Leu Asn Ser Leu Ser Gln
            900                 905                 910         
Leu Ser Tyr Ser Thr Ser Ser Ser Lys Arg Gln Ser Gln Gln Leu Glu
        915                 920                 925             
Ala Leu Gln Gln Gln Val Lys Gln Leu Gln Asn Gln Leu Ala Glu Cys
    930                 935                 940                 
Lys Lys Gln His Gln Glu Val Ile Ser Val Tyr Arg Met His Leu Leu
945                 950                 955                 960 
Tyr Ala Val Gln Gly Gln Met Asp Glu Asp Val Gln Lys Val Leu Lys
                965                 970                 975     
Gln Ile Leu Thr Met Cys Lys Asn Gln Ser Gln Lys Lys
            980                 985                 


<210> 7286
<211> 505
<212> PRT
<213> Homo sapiens

<400> 7286
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu
 1               5                  10                  15      
Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Thr Ala Pro Gly Cys
            20                  25                  30          
Gly Gln Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys
        35                  40                  45              
His Glu Met Thr Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile
    50                  55                  60                  
Val Ala Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu
65                  70                  75                  80  
Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe
                85                  90                  95      
Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser
            100                 105                 110         
Pro Leu Ala Thr Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val
        115                 120                 125             
Val Glu Thr Thr His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Thr
    130                 135                 140                 
Thr Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Thr Ala Gln Pro Thr
145                 150                 155                 160 
Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu
                165                 170                 175     
Thr Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro
            180                 185                 190         
Thr Ser Ser Thr Val Ile Thr Gln Ala Pro Ser Ser Asn Arg Pro Ile
        195                 200                 205             
Val Pro Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly
    210                 215                 220                 
Gln Thr Met Pro Val Ala Ile Pro Ala Ser Ile Thr Ser Ser Asn Val
225                 230                 235                 240 
His Val Pro Ala Ala Val Pro Leu Val Arg Pro Val Thr Met Val Pro
                245                 250                 255     
Ser Val Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser
            260                 265                 270         
Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Thr Gln Gln His Pro Pro
        275                 280                 285             
Val Thr Asn Gly Asp Thr Val Lys Gly His Gly Ser Gly Leu Val Arg
    290                 295                 300                 
Thr Gln Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Thr
305                 310                 315                 320 
Ser Thr Thr Glu Thr Pro Ala Ser Pro Ala His Thr Thr Pro Gln Thr
                325                 330                 335     
Gln Ser Thr Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp
            340                 345                 350         
Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg
        355                 360                 365             
Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala
    370                 375                 380                 
Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Thr Leu
385                 390                 395                 400 
Leu Arg Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys
                405                 410                 415     
Asp Cys Pro Val Thr Ala Met Gln Lys Lys Ser Gly Tyr His Thr Ala
            420                 425                 430         
Asp Lys Asp Asp Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His
        435                 440                 445             
Thr Glu Ala Ile Gln His Ser Ser Val Ser Thr Ser Asn Gly Val Ser
    450                 455                 460                 
Ser Thr Ser Lys Ala Glu Ala Val Ala Thr Ser Val Leu Thr Gln Met
465                 470                 475                 480 
Ala Asp Gln Ser Thr Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro
                485                 490                 495     
Ser Ser Gln Ser Gln Pro Ser Gly Ser
            500                 505 


<210> 7287
<211> 1015
<212> PRT
<213> Homo sapiens

<400> 7287
Met Pro Ile Asn Gly Thr Asp Leu Met Phe Gln His Thr Thr Glu Gly
 1               5                  10                  15      
Ser Cys Val Ile Ser Gln Ala Glu Gly Thr Gly Ala Lys Lys Trp Thr
            20                  25                  30          
Leu Met Gly Asp Leu Leu Phe Val Leu Ser Pro Ile Tyr Ser Ala Thr
        35                  40                  45              
Leu Ser Gly Pro Gly Ala Gly Arg Gly Ser Val Gly Thr Cys Gly Arg
    50                  55                  60                  
Arg Pro Asp Gly Pro Ser Pro Leu Cys Ala Thr Cys Arg Ala Arg Ser
65                  70                  75                  80  
Gln Ser Leu Met Leu Lys Ser Leu Leu Pro Leu Thr Ala Glu Asn Thr
                85                  90                  95      
Glu Gly Arg His Ser Val Ser Met Leu Ile Leu Ala Glu Leu Ala Asp
            100                 105                 110         
Glu Ser Asp Lys Cys Cys Cys Arg Lys Gln Thr Ala Ala Ala Arg His
        115                 120                 125             
Arg Gln Glu Gln Val Ala Ser Gln Gly Arg Pro Asn Lys Arg Lys His
    130                 135                 140                 
Leu Phe Gly Leu Ile Gln Lys Asp Val Gly Lys Glu Glu Ala Val Glu
145                 150                 155                 160 
Gly Asp Asp Ala Leu Glu Gly Leu Gly Ala Lys Asp Ile Lys Leu Ala
                165                 170                 175     
Val Thr Arg Glu Pro Ser Gln Gly Ala Gly Gly Glu Met Ser Pro Cys
            180                 185                 190         
Gly Arg Lys Met Gly Glu Gly Arg Gln Gln Arg Arg Ala Pro Val Gly
        195                 200                 205             
Lys Leu Leu Leu Leu Pro Gly Arg Arg Asp Thr Pro His Gly Arg Ser
    210                 215                 220                 
Gly Ser Ser Gly Ala Arg Thr Gln Arg Ser Leu Leu Trp Leu Leu Val
225                 230                 235                 240 
His Val Trp Leu Trp Ala Ala Ser Gly Ser Ser Ala Gln Leu Phe Asn
                245                 250                 255     
Leu Thr Leu Ser Val Asp Glu Gly Leu Pro Pro Asp Thr Leu Val Gly
            260                 265                 270         
Asp Ile Arg Ala Gly Leu Pro Ala Ala Gln Gln Gln Glu Gly Ser Gly
        275                 280                 285             
Phe Phe Leu Ser Glu Asp Ser Asp Asp Ser Pro Leu Leu Asp Asp Phe
    290                 295                 300                 
His Val His Pro Asp Thr Gly Ile Ile Arg Thr Ala Arg Arg Leu Asp
305                 310                 315                 320 
Arg Glu Arg Arg Asp His Tyr Ser Phe Val Ala Ala Thr Leu Leu Gly
                325                 330                 335     
Ala Val Val Gln Val Glu Ile Arg Val Asn Asp Val Asn Asp His Ser
            340                 345                 350         
Pro Arg Phe Pro Leu Asp Ser Leu Gln Leu Asp Val Ser Glu Leu Ser
        355                 360                 365             
Pro Pro Gly Thr Ala Phe Arg Leu Pro Val Ala His Asp Pro Asp Ala
    370                 375                 380                 
Gly Leu Phe Ser Thr Gln Gly Tyr Thr Leu Val Gln Pro Ser Asp Leu
385                 390                 395                 400 
Pro Lys Asp Pro Ala Gly Pro Phe Phe Gln Leu Arg Tyr Arg Thr Pro
                405                 410                 415     
Gly Pro Leu Pro Ser Pro Leu Leu Pro Gly Ser Ser Ser Pro Leu Glu
            420                 425                 430         
Pro Leu Asp Leu Val Leu Leu Arg Arg Leu Asp Arg Glu Glu Ala Ala
        435                 440                 445             
Ala His Arg Leu Gln Ile Glu Ala Trp Asp Gly Gly Arg Pro Arg Arg
    450                 455                 460                 
Thr Gly Leu Leu Ser Val Glu Leu Arg Val Leu Asp Glu Asn Asp Asn
465                 470                 475                 480 
Pro Pro Val Phe Glu Gln Asp Glu Tyr Arg Ala Ala Val Arg Glu Asp
                485                 490                 495     
Ala Gln Pro Gly Ala Glu Val Cys Arg Val Arg Ala Thr Asp Arg Asp
            500                 505                 510         
Leu Gly Pro Asn Gly Phe Val Arg Tyr Ser Val Arg Ala Arg Gln Val
        515                 520                 525             
Pro Gly Ala Gly Ser Gly Gly Gly Ala Leu Gly Asp Ala Ala Tyr Phe
    530                 535                 540                 
Ala Val Glu Glu Leu Ser Gly Val Val Arg Val Trp Arg Pro Leu Asp
545                 550                 555                 560 
Arg Glu Ala Gln Ala Trp His Gln Leu Val Val Glu Ala Arg Asp Gly
                565                 570                 575     
Gly Ala Glu Pro Glu Val Ala Thr Val Arg Val Ser Ile Ala Val Leu
            580                 585                 590         
Asp Val Asn Asp Asn Arg Pro Ala Ile His Val Leu Phe Leu Thr Glu
        595                 600                 605             
Gly Gly Val Ala Arg Val Ser Glu Gly Ala Arg Pro Gly Asp Tyr Val
    610                 615                 620                 
Ala Arg Val Ser Val Ser Asp Ala Asp Gly Asp Trp Glu Lys Glu Asp
625                 630                 635                 640 
Glu Ala Thr Gly Glu Leu Gly Val Gly Leu Gly Asp Gly Ser Ile Ser
                645                 650                 655     
Leu Ser Leu Glu Gly Gly Glu Gly Asp Phe Ala Leu Leu Pro Gly Gly
            660                 665                 670         
Pro Pro Gly Val Phe Phe Leu Cys Val Glu Gly Pro Leu Asp Arg Glu
        675                 680                 685             
Ser Arg Asp Leu Tyr Glu Leu Leu Leu Val Ala Thr Asp Ala Gly Ser
    690                 695                 700                 
Pro Pro Leu Ser Thr Glu Glu Thr Leu Leu Leu Arg Val Ala Asp Leu
705                 710                 715                 720 
Asn Asp Gln Pro Pro Leu Phe Ser Gln Gln His Tyr Lys Ala Ser Val
                725                 730                 735     
Ser Glu Ala Ala Ala Pro Gly Thr Val Val Met Trp Val Ser Ala Ser
            740                 745                 750         
Asp Ala Asp Glu Ala Gly Ser Asp His Ala Trp Leu Arg Tyr Thr Val
        755                 760                 765             
Val Gln Leu Ser Ala Pro Cys Asn Leu Gly Ser Leu Gln Ser Lys Met
    770                 775                 780                 
Val His Thr Ala Glu Cys Gly Pro Ser Phe Ala Ile Asp Ser Glu Ser
785                 790                 795                 800 
Gly Ala Ile Ser Thr Ile Arg Thr Leu Asp Arg Glu Val Gln Glu Ala
                805                 810                 815     
Val Glu Leu Lys Val Val Ala Gln Asp Leu Gly Glu Pro Pro Leu Ser
            820                 825                 830         
Ala Thr Cys Leu Val Ser Ile Thr Val Asp Asp Val Asn Asp Asn Glu
        835                 840                 845             
Pro Ile Phe Trp Arg Gln Val Tyr Asn Ala Thr Ile Ala Glu His Ala
    850                 855                 860                 
Pro Val Gly His Cys Phe Leu Gln Val Thr Ala Ser Asp Ala Asp Ser
865                 870                 875                 880 
Gly Leu Tyr Gly Phe Ile Glu Tyr Ser Leu Tyr Asp Gly Phe Leu Ser
                885                 890                 895     
Tyr Glu Ala Pro Gln Ala Phe Arg Ile Asp Pro His Asp Gly Gln Ile
            900                 905                 910         
Cys Val Ser Gln Asp Ile Asp Arg Glu Arg Asp Pro Ala Thr Tyr Asp
        915                 920                 925             
Leu Leu Val Glu Ala Lys Asp Gly Gly Gly Leu Ser Ala Gln Ala Phe
    930                 935                 940                 
Val Arg Val Asp Leu Glu Asp Val Asn Asp Asn His Pro Val Phe Asn
945                 950                 955                 960 
Pro Ser Thr Tyr Val Thr Ser Ile Ser Asp Glu Thr Gln Pro Gly Thr
                965                 970                 975     
Glu Ile Ile Asn Val Leu Ala Thr Asp Gln Asp Ser Gly Ile Tyr Gly
            980                 985                 990         
Thr Val Ala Tyr Glu Leu Ile Pro Gly Asn Val Ser Ser Leu Phe Thr
        995                 1000                1005            
Ile Asp Ser Thr Thr Gly Met
    1010                1015


<210> 7288
<211> 841
<212> PRT
<213> Homo sapiens

<400> 7288
Met Leu Glu Arg Lys Tyr Gly Gly Arg Leu Val Thr Arg His Ala Ala
 1               5                  10                  15      
Arg Thr Ile Gln Thr Ala Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe
            20                  25                  30          
Glu Arg Leu Arg Ser Ser Met Ser Glu Asn Arg Met Ser Arg Arg Ile
        35                  40                  45              
Val Leu Ser Asn Met Arg Met Gln Phe Ser Phe Glu Gly Pro Glu Lys
    50                  55                  60                  
Val His Ser Ser Tyr Phe Glu Gly Lys Gln Val Ser Val Thr Asn Asp
65                  70                  75                  80  
Gly Ser Gln Leu Gly Ala Leu Val Ser Pro Glu Cys Gly Asp Leu Ser
                85                  90                  95      
Glu Pro Thr Thr Leu Lys Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp
            100                 105                 110         
Ala Ile Thr Glu Leu Glu Asp Ala Phe Ser Arg Gln Val Lys Ser Leu
        115                 120                 125             
Ala Glu Ser Ile Asp Asp Ala Leu Asn Cys Arg Ser Leu His Thr Glu
    130                 135                 140                 
Glu Ala Pro Ala Leu Asp Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln
145                 150                 155                 160 
Thr Ala Leu His Gly Met Asp His Arg Lys Leu Asp Glu Met Thr Ala
                165                 170                 175     
Ser Tyr Ser Asp Val Thr Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro
            180                 185                 190         
Pro Leu Pro Leu Ser Gln Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser
        195                 200                 205             
Asp Leu Arg Leu Arg Ala Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu
    210                 215                 220                 
Ala His Lys Glu Asp Lys Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr
225                 230                 235                 240 
Pro Ser Leu Glu Arg Gln Glu Gln Arg Leu Arg Val Glu His Leu Pro
                245                 250                 255     
Leu Leu Thr Ile Glu Pro Pro Ser Asp Ser Ser Val Asp Leu Ser Asp
            260                 265                 270         
Arg Ser Glu Arg Gly Ser Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser
        275                 280                 285             
Leu Gly Gly Gln Gln Gly Ser Pro Lys His Gly Pro His Ser Gly Ala
    290                 295                 300                 
Pro Lys Ser Leu Pro Arg Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro
305                 310                 315                 320 
Arg Pro Leu Asp Ser His Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln
                325                 330                 335     
Ser Lys Ser Glu Ser Asp Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn
            340                 345                 350         
Ser Thr Ser Asn Ser Asn Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser
        355                 360                 365             
Ser Arg Asp Ser Leu Arg Glu Gln Thr Leu Ser Lys Gln Thr Tyr His
    370                 375                 380                 
Lys Glu Ala Arg Asn Ser Trp Asp Ser Pro Ala Phe Ser Asn Asp Val
385                 390                 395                 400 
Ile Arg Lys Arg His Tyr Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys
                405                 410                 415     
Pro Glu Lys Gly Val Gln Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp
            420                 425                 430         
Thr Pro Val Gly Val Ala His Phe Leu Leu Gln Arg Lys Gly Leu Ser
        435                 440                 445             
Arg Gln Met Ile Gly Glu Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn
    450                 455                 460                 
Arg Asp Val Leu Asp Cys Val Val Asp Glu Met Asp Phe Ser Thr Met
465                 470                 475                 480 
Glu Leu Asp Glu Ala Leu Arg Lys Phe Gln Ala His Ile Arg Val Gln
                485                 490                 495     
Gly Glu Ala Gln Lys Val Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg
            500                 505                 510         
Tyr Cys Ile Cys Asn Pro Gly Val Val Arg Gln Phe Arg Asn Pro Asp
        515                 520                 525             
Thr Ile Phe Ile Leu Ala Phe Ala Ile Ile Leu Leu Asn Thr Asp Met
    530                 535                 540                 
Tyr Ser Pro Asn Val Lys Pro Glu Arg Lys Met Lys Leu Glu Asp Phe
545                 550                 555                 560 
Ile Lys Asn Leu Arg Gly Val Asp Asp Gly Glu Asp Ile Pro Arg Glu
                565                 570                 575     
Met Leu Met Gly Ile Tyr Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr
            580                 585                 590         
Asn Glu Asp His Val Ser Gln Val Gln Lys Val Glu Lys Leu Ile Val
        595                 600                 605             
Gly Lys Lys Pro Ile Gly Ser Leu His Pro Gly Leu Gly Cys Val Leu
    610                 615                 620                 
Ser Leu Pro His Arg Arg Leu Val Cys Tyr Cys Arg Leu Phe Glu Val
625                 630                 635                 640 
Pro Asp Pro Asn Lys Pro Gln Lys Leu Gly Leu His Gln Arg Glu Ile
                645                 650                 655     
Phe Leu Phe Asn Asp Leu Leu Val Val Thr Lys Ile Phe Gln Lys Lys
            660                 665                 670         
Lys Asn Ser Val Thr Tyr Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly
        675                 680                 685             
Met Gln Val Leu Leu Phe Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg
    690                 695                 700                 
Leu Thr Ser Ser Val Pro Gly Ala Asp Ile Lys Val Leu Ile Asn Phe
705                 710                 715                 720 
Asn Ala Pro Asn Pro Gln Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg
                725                 730                 735     
Glu Ser Ile Ala Glu Val Gln Glu Met Glu Lys His Arg Ile Glu Ser
            740                 745                 750         
Glu Leu Glu Lys Gln Lys Gly Val Val Arg Pro Ser Met Ser Gln Cys
        755                 760                 765             
Ser Ser Leu Lys Lys Glu Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys
    770                 775                 780                 
Leu Asp Asp Ser Tyr Ala Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu
785                 790                 795                 800 
Ser Ser Ser Leu Arg Asp Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg
                805                 810                 815     
Ser Ser Ala Gly Ser Leu Glu Ser Asn Val Glu Phe Gln Pro Phe Glu
            820                 825                 830         
Pro Leu Gln Pro Ser Val Leu Cys Ser
        835                 840     


<210> 7289
<211> 701
<212> PRT
<213> Homo sapiens

<400> 7289
Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val
 1               5                  10                  15      
Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr
            20                  25                  30          
Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly
        35                  40                  45              
Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys
    50                  55                  60                  
Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys
65                  70                  75                  80  
Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr
                85                  90                  95      
Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser
            100                 105                 110         
Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys
        115                 120                 125             
Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln
    130                 135                 140                 
Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser
145                 150                 155                 160 
Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu
                165                 170                 175     
Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val
            180                 185                 190         
Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu
        195                 200                 205             
Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val
    210                 215                 220                 
Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu
225                 230                 235                 240 
Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly
                245                 250                 255     
Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln
            260                 265                 270         
Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala
        275                 280                 285             
Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr
    290                 295                 300                 
Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro
305                 310                 315                 320 
Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly
                325                 330                 335     
Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu
            340                 345                 350         
Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val
        355                 360                 365             
Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser
    370                 375                 380                 
Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg
385                 390                 395                 400 
Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn
                405                 410                 415     
Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly
            420                 425                 430         
Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr
        435                 440                 445             
Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu
    450                 455                 460                 
Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu
465                 470                 475                 480 
Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser Asn
                485                 490                 495     
Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu
            500                 505                 510         
Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile
        515                 520                 525             
Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser
    530                 535                 540                 
Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met
545                 550                 555                 560 
Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu
                565                 570                 575     
Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro
            580                 585                 590         
Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala
        595                 600                 605             
Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala
    610                 615                 620                 
Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His
625                 630                 635                 640 
Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn
                645                 650                 655     
Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys
            660                 665                 670         
Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val
        675                 680                 685             
Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro
    690                 695                 700     


<210> 7290
<211> 741
<212> PRT
<213> Homo sapiens

<400> 7290
Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val
 1               5                  10                  15      
Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr
            20                  25                  30          
Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly
        35                  40                  45              
Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys
    50                  55                  60                  
Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys
65                  70                  75                  80  
Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr
                85                  90                  95      
Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser
            100                 105                 110         
Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys
        115                 120                 125             
Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln
    130                 135                 140                 
Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser
145                 150                 155                 160 
Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu
                165                 170                 175     
Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val
            180                 185                 190         
Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu
        195                 200                 205             
Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val
    210                 215                 220                 
Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu
225                 230                 235                 240 
Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly
                245                 250                 255     
Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln
            260                 265                 270         
Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala
        275                 280                 285             
Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr
    290                 295                 300                 
Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro
305                 310                 315                 320 
Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly
                325                 330                 335     
Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu
            340                 345                 350         
Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val
        355                 360                 365             
Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser
    370                 375                 380                 
Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg
385                 390                 395                 400 
Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn
                405                 410                 415     
Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly
            420                 425                 430         
Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr
        435                 440                 445             
Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu
    450                 455                 460                 
Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His
465                 470                 475                 480 
Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr
                485                 490                 495     
Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro
            500                 505                 510         
Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu
        515                 520                 525             
Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly
    530                 535                 540                 
Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile
545                 550                 555                 560 
Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe
                565                 570                 575     
Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His
            580                 585                 590         
Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu
        595                 600                 605             
Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile
    610                 615                 620                 
Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val
625                 630                 635                 640 
Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr
                645                 650                 655     
Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu
            660                 665                 670         
Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu
        675                 680                 685             
Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala
    690                 695                 700                 
Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile
705                 710                 715                 720 
Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln
                725                 730                 735     
Phe Ser Leu Thr Pro
            740     


<210> 7291
<211> 714
<212> PRT
<213> Homo sapiens

<400> 7291
Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val
 1               5                  10                  15      
Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr
            20                  25                  30          
Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly
        35                  40                  45              
Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys
    50                  55                  60                  
Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys
65                  70                  75                  80  
Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr
                85                  90                  95      
Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser
            100                 105                 110         
Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys
        115                 120                 125             
Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln
    130                 135                 140                 
Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser
145                 150                 155                 160 
Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu
                165                 170                 175     
Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val
            180                 185                 190         
Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu
        195                 200                 205             
Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val
    210                 215                 220                 
Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu
225                 230                 235                 240 
Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly
                245                 250                 255     
Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln
            260                 265                 270         
Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala
        275                 280                 285             
Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr
    290                 295                 300                 
Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro
305                 310                 315                 320 
Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly
                325                 330                 335     
Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu
            340                 345                 350         
Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val
        355                 360                 365             
Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser
    370                 375                 380                 
Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg
385                 390                 395                 400 
Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn
                405                 410                 415     
Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly
            420                 425                 430         
Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr
        435                 440                 445             
Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu
    450                 455                 460                 
Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His
465                 470                 475                 480 
Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr
                485                 490                 495     
Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro
            500                 505                 510         
Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu
        515                 520                 525             
Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly
    530                 535                 540                 
Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile
545                 550                 555                 560 
Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe
                565                 570                 575     
Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His
            580                 585                 590         
Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu
        595                 600                 605             
Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile
    610                 615                 620                 
Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val
625                 630                 635                 640 
Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr
                645                 650                 655     
Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu
            660                 665                 670         
Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu
        675                 680                 685             
Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala
    690                 695                 700                 
Ala Lys Glu Tyr Gln Ala Ala Lys Val His
705                 710                 


<210> 7292
<211> 1877
<212> PRT
<213> Homo sapiens

<400> 7292
Met Leu Gly Ser Ser Val Lys Ser Val Gln Pro Glu Val Glu Leu Ser
 1               5                  10                  15      
Ser Gly Gly Gly Asp Glu Gly Ala Asp Glu Pro Arg Gly Ala Gly Arg
            20                  25                  30          
Lys Ala Ala Ala Ala Asp Gly Arg Gly Met Leu Pro Lys Arg Ala Lys
        35                  40                  45              
Ala Pro Gly Gly Gly Gly Gly Met Ala Lys Ala Ser Ala Ala Glu Leu
    50                  55                  60                  
Lys Val Phe Lys Ser Gly Ser Val Asp Ser Arg Val Pro Gly Gly Pro
65                  70                  75                  80  
Pro Ala Ser Asn Leu Arg Lys Gln Lys Ser Leu Thr Asn Leu Ser Phe
                85                  90                  95      
Leu Thr Asp Ser Glu Lys Lys Leu Gln Leu Tyr Glu Pro Glu Trp Ser
            100                 105                 110         
Asp Asp Met Ala Lys Ala Pro Lys Gly Leu Gly Lys Val Gly Ser Lys
        115                 120                 125             
Gly Arg Glu Ala Pro Leu Met Ser Lys Thr Leu Ser Lys Ser Glu His
    130                 135                 140                 
Ser Leu Phe Gln Ala Lys Gly Ser Pro Ala Gly Gly Ala Lys Thr Pro
145                 150                 155                 160 
Leu Ala Pro Leu Ala Pro Asn Leu Gly Lys Pro Ser Arg Ile Pro Arg
                165                 170                 175     
Gly Pro Tyr Ala Glu Val Lys Pro Leu Ser Lys Ala Pro Glu Ala Ala
            180                 185                 190         
Val Ser Glu Asp Gly Lys Ser Asp Asp Glu Leu Leu Ser Ser Lys Ala
        195                 200                 205             
Lys Ala Gln Lys Ser Ser Gly Pro Val Pro Ser Ala Lys Gly Gln Glu
    210                 215                 220                 
Glu Arg Ala Phe Leu Lys Val Asp Pro Glu Leu Val Val Thr Val Leu
225                 230                 235                 240 
Gly Asp Leu Glu Gln Leu Leu Phe Ser Gln Met Leu Asp Pro Glu Ser
                245                 250                 255     
Gln Arg Lys Arg Thr Val Gln Asn Val Leu Asp Leu Arg Gln Asn Leu
            260                 265                 270         
Glu Glu Thr Met Ser Ser Leu Arg Gly Ser Gln Val Thr His Ser Ser
        275                 280                 285             
Leu Glu Met Thr Cys Tyr Asp Ser Asp Asp Ala Asn Pro Arg Ser Val
    290                 295                 300                 
Ser Ser Leu Ser Asn Arg Ser Ser Pro Leu Ser Trp Arg Tyr Gly Gln
305                 310                 315                 320 
Ser Ser Pro Arg Leu Gln Ala Gly Asp Ala Pro Ser Val Gly Gly Ser
                325                 330                 335     
Cys Arg Ser Glu Gly Thr Pro Ala Trp Tyr Met His Gly Glu Arg Ala
            340                 345                 350         
His Tyr Ser His Thr Met Pro Met Arg Ser Pro Ser Lys Leu Ser His
        355                 360                 365             
Ile Ser Arg Leu Glu Leu Val Glu Ser Leu Asp Ser Asp Glu Val Asp
    370                 375                 380                 
Leu Lys Ser Gly Tyr Met Ser Asp Ser Asp Leu Met Gly Lys Thr Met
385                 390                 395                 400 
Thr Glu Asp Asp Asp Ile Thr Thr Gly Trp Asp Glu Ser Ser Ser Ile
                405                 410                 415     
Arg Ser Gly Leu Ser Asp Ala Ser Asp Asn Leu Ser Ser Glu Glu Phe
            420                 425                 430         
Asn Ala Ser Ser Ser Leu Asn Ser Leu Pro Ser Thr Pro Thr Ala Ser
        435                 440                 445             
Arg Arg Asn Ser Thr Ile Val Leu Arg Thr Asp Ser Glu Lys Arg Ser
    450                 455                 460                 
Leu Ala Glu Ser Gly Leu Ser Trp Phe Ser Glu Ser Glu Glu Lys Ala
465                 470                 475                 480 
Pro Lys Lys Leu Glu Tyr Asp Ser Gly Ser Leu Lys Met Glu Pro Gly
                485                 490                 495     
Thr Ser Lys Trp Arg Arg Glu Arg Pro Glu Ser Cys Asp Asp Ser Ser
            500                 505                 510         
Lys Gly Gly Glu Leu Lys Lys Pro Ile Ser Leu Gly His Pro Gly Ser
        515                 520                 525             
Leu Lys Lys Gly Lys Thr Pro Pro Val Ala Val Thr Ser Pro Ile Thr
    530                 535                 540                 
His Thr Ala Gln Ser Ala Leu Lys Val Ala Gly Lys Pro Glu Gly Lys
545                 550                 555                 560 
Ala Thr Asp Lys Gly Lys Leu Ala Val Lys Asn Thr Gly Leu Gln Arg
                565                 570                 575     
Ser Ser Ser Asp Ala Gly Arg Asp Arg Leu Ser Asp Ala Lys Lys Pro
            580                 585                 590         
Pro Ser Gly Ile Ala Arg Pro Ser Thr Ser Gly Ser Phe Gly Tyr Lys
        595                 600                 605             
Lys Pro Pro Pro Ala Thr Gly Thr Ala Thr Val Met Gln Thr Gly Gly
    610                 615                 620                 
Ser Ala Thr Leu Ser Lys Ile Gln Lys Ser Ser Gly Ile Pro Val Lys
625                 630                 635                 640 
Pro Val Asn Gly Arg Lys Thr Ser Leu Asp Val Ser Asn Ser Ala Glu
                645                 650                 655     
Pro Gly Phe Leu Ala Pro Gly Ala Arg Ser Asn Ile Gln Tyr Arg Ser
            660                 665                 670         
Leu Pro Arg Pro Ala Lys Ser Ser Ser Met Ser Val Thr Gly Gly Arg
        675                 680                 685             
Gly Gly Pro Arg Pro Val Ser Ser Ser Ile Asp Pro Ser Leu Leu Ser
    690                 695                 700                 
Thr Lys Gln Gly Gly Leu Thr Pro Ser Arg Leu Lys Glu Pro Thr Lys
705                 710                 715                 720 
Val Ala Ser Gly Arg Thr Thr Pro Ala Pro Val Asn Gln Thr Asp Arg
                725                 730                 735     
Glu Lys Glu Lys Ala Lys Ala Lys Ala Val Ala Leu Asp Ser Asp Asn
            740                 745                 750         
Ile Ser Leu Lys Ser Ile Gly Ser Pro Glu Ser Thr Pro Lys Asn Gln
        755                 760                 765             
Ala Ser His Pro Thr Ala Thr Lys Leu Ala Glu Leu Pro Pro Thr Pro
    770                 775                 780                 
Leu Arg Ala Thr Ala Lys Ser Phe Val Lys Pro Pro Ser Leu Ala Asn
785                 790                 795                 800 
Leu Asp Lys Val Asn Ser Asn Ser Leu Asp Leu Pro Ser Ser Ser Asp
                805                 810                 815     
Thr Thr His Ala Ser Lys Val Pro Asp Leu His Ala Thr Ser Ser Ala
            820                 825                 830         
Ser Gly Gly Pro Leu Pro Ser Cys Phe Thr Pro Ser Pro Ala Pro Ile
        835                 840                 845             
Leu Asn Ile Asn Ser Ala Ser Phe Ser Gln Gly Leu Glu Leu Met Ser
    850                 855                 860                 
Gly Phe Ser Val Pro Lys Glu Thr Arg Met Tyr Pro Lys Leu Ser Gly
865                 870                 875                 880 
Leu His Arg Ser Met Glu Ser Leu Gln Met Pro Met Ser Leu Pro Ser
                885                 890                 895     
Ala Phe Pro Ser Ser Thr Pro Val Pro Thr Pro Pro Ala Pro Pro Ala
            900                 905                 910         
Ala Pro Thr Glu Glu Glu Thr Glu Glu Leu Thr Trp Ser Gly Ser Pro
        915                 920                 925             
Arg Ala Gly Gln Leu Asp Ser Asn Gln Arg Asp Arg Asn Thr Leu Pro
    930                 935                 940                 
Lys Lys Gly Leu Arg Tyr Gln Leu Gln Ser Gln Glu Glu Thr Lys Glu
945                 950                 955                 960 
Arg Arg His Ser His Thr Ile Gly Gly Leu Pro Glu Ser Asp Asp Gln
                965                 970                 975     
Ser Glu Leu Pro Ser Pro Pro Ala Leu Pro Met Ser Leu Ser Ala Lys
            980                 985                 990         
Gly Gln Leu Thr Asn Ile Val Ser Pro Thr Ala Ala Thr Thr Pro Arg
        995                 1000                1005            
Ile Thr Arg Ser Asn Ser Ile Pro Thr His Glu Ala Ala Phe Glu Leu
    1010                1015                1020                
Tyr Ser Gly Ser Gln Met Gly Ser Thr Leu Ser Leu Ala Glu Arg Pro
1025                1030                1035                1040
Lys Gly Met Ile Arg Ser Gly Ser Phe Arg Asp Pro Thr Asp Asp Val
                1045                1050                1055    
His Gly Ser Val Leu Ser Leu Ala Ser Ser Ala Ser Ser Thr Tyr Ser
            1060                1065                1070        
Ser Ala Glu Glu Arg Met Gln Ser Glu Gln Ile Arg Lys Leu Arg Arg
        1075                1080                1085            
Glu Leu Glu Ser Ser Gln Glu Lys Val Ala Thr Leu Thr Ser Gln Leu
    1090                1095                1100                
Ser Ala Asn Ala Asn Leu Val Ala Ala Phe Glu Gln Ser Leu Val Asn
1105                1110                1115                1120
Met Thr Ser Arg Leu Arg His Leu Ala Glu Thr Ala Glu Glu Lys Asp
                1125                1130                1135    
Thr Glu Leu Leu Asp Leu Arg Glu Thr Ile Asp Phe Leu Lys Lys Lys
            1140                1145                1150        
Asn Ser Glu Ala Gln Ala Val Ile Gln Gly Ala Leu Asn Ala Ser Glu
        1155                1160                1165            
Thr Thr Pro Lys Glu Leu Arg Ile Lys Arg Gln Asn Ser Ser Asp Ser
    1170                1175                1180                
Ile Ser Ser Leu Asn Ser Ile Thr Ser His Ser Ser Ile Gly Ser Ser
1185                1190                1195                1200
Lys Asp Ala Asp Ala Lys Lys Lys Lys Lys Lys Ser Trp Val Tyr Glu
                1205                1210                1215    
Leu Arg Ser Ser Phe Asn Lys Ala Phe Ser Ile Lys Lys Gly Pro Lys
            1220                1225                1230        
Ser Ala Ser Ser Tyr Ser Asp Ile Glu Glu Ile Ala Thr Pro Asp Ser
        1235                1240                1245            
Ser Ala Pro Ser Ser Pro Lys Leu Gln His Gly Ser Thr Glu Thr Ala
    1250                1255                1260                
Ser Pro Ser Ile Lys Ser Ser Thr Leu Ser Ser Val Gly Thr Asp Val
1265                1270                1275                1280
Thr Glu Gly Pro Ala His Pro Ala Pro His Thr Arg Leu Phe His Ala
                1285                1290                1295    
Asn Glu Glu Glu Glu Pro Glu Lys Lys Glu Val Ser Glu Leu Arg Ser
            1300                1305                1310        
Glu Leu Trp Glu Lys Glu Met Lys Leu Thr Asp Ile Arg Leu Glu Ala
        1315                1320                1325            
Leu Asn Ser Ala His Gln Leu Asp Gln Leu Arg Glu Thr Met His Asn
    1330                1335                1340                
Met Gln Leu Glu Val Asp Leu Leu Lys Ala Glu Asn Asp Arg Leu Lys
1345                1350                1355                1360
Val Ala Pro Gly Pro Ser Ser Gly Ser Thr Pro Gly Gln Val Pro Gly
                1365                1370                1375    
Ser Ser Ala Leu Ser Ser Pro Arg Arg Ser Leu Gly Leu Ala Leu Thr
            1380                1385                1390        
His Ser Phe Gly Pro Ser Leu Ala Asp Thr Asp Leu Ser Pro Met Asp
        1395                1400                1405            
Gly Ile Ser Thr Cys Gly Pro Lys Glu Glu Val Thr Leu Arg Val Val
    1410                1415                1420                
Val Arg Met Pro Pro Gln His Ile Ile Lys Gly Asp Leu Lys Gln Gln
1425                1430                1435                1440
Glu Phe Phe Leu Gly Cys Ser Lys Val Ser Gly Lys Val Asp Trp Lys
                1445                1450                1455    
Met Leu Asp Glu Ala Val Phe Gln Val Phe Lys Asp Tyr Ile Ser Lys
            1460                1465                1470        
Met Asp Pro Ala Ser Thr Leu Gly Leu Ser Thr Glu Ser Ile His Gly
        1475                1480                1485            
Tyr Ser Ile Ser His Val Lys Arg Val Leu Asp Ala Glu Pro Pro Glu
    1490                1495                1500                
Met Pro Pro Cys Arg Arg Gly Val Asn Asn Ile Ser Val Ser Leu Lys
1505                1510                1515                1520
Gly Leu Lys Glu Lys Cys Val Asp Ser Leu Val Phe Glu Thr Leu Ile
                1525                1530                1535    
Pro Lys Pro Met Met Gln His Tyr Ile Ser Leu Leu Leu Lys His Arg
            1540                1545                1550        
Arg Leu Val Leu Ser Gly Pro Ser Gly Thr Gly Lys Thr Tyr Leu Thr
        1555                1560                1565            
Asn Arg Leu Ala Glu Tyr Leu Val Glu Arg Ser Gly Arg Glu Val Thr
    1570                1575                1580                
Glu Gly Ile Val Ser Thr Phe Asn Met His Gln Gln Ser Cys Lys Asp
1585                1590                1595                1600
Leu Gln Leu Tyr Leu Ser Asn Leu Ala Asn Gln Ile Asp Arg Glu Thr
                1605                1610                1615    
Gly Ile Gly Asp Val Pro Leu Val Ile Leu Leu Asp Asp Leu Ser Glu
            1620                1625                1630        
Ala Gly Ser Ile Ser Glu Leu Val Asn Gly Ala Leu Thr Cys Lys Tyr
        1635                1640                1645            
His Lys Cys Pro Tyr Ile Ile Gly Thr Thr Asn Gln Pro Val Lys Met
    1650                1655                1660                
Thr Pro Asn His Gly Leu His Leu Ser Phe Arg Met Leu Thr Phe Ser
1665                1670                1675                1680
Asn Asn Val Glu Pro Ala Asn Gly Phe Leu Val Arg Tyr Leu Arg Arg
                1685                1690                1695    
Lys Leu Val Glu Ser Asp Ser Asp Ile Asn Ala Asn Lys Glu Glu Leu
            1700                1705                1710        
Leu Arg Val Leu Asp Trp Val Pro Lys Leu Trp Tyr His Leu His Thr
        1715                1720                1725            
Phe Leu Glu Lys His Ser Thr Ser Asp Phe Leu Ile Gly Pro Cys Phe
    1730                1735                1740                
Phe Leu Ser Cys Pro Ile Gly Ile Glu Asp Phe Arg Thr Trp Phe Ile
1745                1750                1755                1760
Asp Leu Trp Asn Asn Ser Ile Ile Pro Tyr Leu Gln Glu Gly Ala Lys
                1765                1770                1775    
Asp Gly Ile Lys Val His Gly Gln Lys Ala Ala Trp Glu Asp Pro Val
            1780                1785                1790        
Glu Trp Val Arg Asp Thr Leu Pro Trp Pro Ser Ala Gln Gln Asp Gln
        1795                1800                1805            
Ser Lys Leu Tyr His Leu Pro Pro Pro Thr Val Gly Pro His Ser Ile
    1810                1815                1820                
Ala Ser Pro Pro Glu Asp Arg Thr Val Lys Asp Ser Thr Pro Ser Ser
1825                1830                1835                1840
Leu Asp Ser Asp Pro Leu Met Ala Met Leu Leu Lys Leu Gln Glu Ala
                1845                1850                1855    
Ala Asn Tyr Ile Glu Ser Pro Asp Arg Glu Thr Ile Leu Asp Pro Asn
            1860                1865                1870        
Leu Gln Ala Thr Leu
        1875        


<210> 7293
<211> 2843
<212> PRT
<213> Homo sapiens

<400> 7293
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu
 1               5                  10                  15      
Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn
            20                  25                  30          
His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu
        35                  40                  45              
Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly
    50                  55                  60                  
Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser
65                  70                  75                  80  
Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr
                85                  90                  95      
Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro
            100                 105                 110         
Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg
        115                 120                 125             
Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu
    130                 135                 140                 
Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala
145                 150                 155                 160 
Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu
                165                 170                 175     
Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu
            180                 185                 190         
Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln
        195                 200                 205             
Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile
    210                 215                 220                 
Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr
225                 230                 235                 240 
Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp
                245                 250                 255     
Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala
            260                 265                 270         
Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr
        275                 280                 285             
Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu
    290                 295                 300                 
Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser
305                 310                 315                 320 
Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala
                325                 330                 335     
Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys
            340                 345                 350         
Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val
        355                 360                 365             
Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser
    370                 375                 380                 
Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly
385                 390                 395                 400 
Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr
                405                 410                 415     
Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp
            420                 425                 430         
Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro
        435                 440                 445             
Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His
    450                 455                 460                 
Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln
465                 470                 475                 480 
Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr
                485                 490                 495     
Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp
            500                 505                 510         
Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala
        515                 520                 525             
Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile
    530                 535                 540                 
Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys
545                 550                 555                 560 
Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala
                565                 570                 575     
Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu
            580                 585                 590         
Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala
        595                 600                 605             
Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser
    610                 615                 620                 
Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg
625                 630                 635                 640 
Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu
                645                 650                 655     
Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His
            660                 665                 670         
Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser
        675                 680                 685             
Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val
    690                 695                 700                 
Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met
705                 710                 715                 720 
Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys
                725                 730                 735     
Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu
            740                 745                 750         
His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His
        755                 760                 765             
Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser
    770                 775                 780                 
His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val
785                 790                 795                 800 
Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr
                805                 810                 815     
Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro
            820                 825                 830         
Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys
        835                 840                 845             
Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His
    850                 855                 860                 
Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile
865                 870                 875                 880 
Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala
                885                 890                 895     
Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu
            900                 905                 910         
His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala
        915                 920                 925             
His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn
    930                 935                 940                 
Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser
945                 950                 955                 960 
Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg
                965                 970                 975     
Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser
            980                 985                 990         
Lys Phe Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile
        995                 1000                1005            
His Ser Ala Asn His Met Asp Asp Asn Asp Gly Glu Leu Asp Thr Pro
    1010                1015                1020                
Ile Asn Tyr Ser Leu Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg
1025                1030                1035                1040
Gln Ser Pro Ser Gln Asn Glu Arg Trp Ala Arg Pro Lys His Ile Ile
                1045                1050                1055    
Glu Asp Glu Ile Lys Gln Ser Glu Gln Arg Gln Ser Arg Asn Gln Ser
            1060                1065                1070        
Thr Thr Tyr Pro Val Tyr Thr Glu Ser Thr Asp Asp Lys His Leu Lys
        1075                1080                1085            
Phe Gln Pro His Phe Gly Gln Gln Glu Cys Val Ser Pro Tyr Arg Ser
    1090                1095                1100                
Arg Gly Ala Asn Gly Ser Glu Thr Asn Arg Val Gly Ser Asn His Gly
1105                1110                1115                1120
Ile Asn Gln Asn Val Ser Gln Ser Leu Cys Gln Glu Asp Asp Tyr Glu
                1125                1130                1135    
Asp Asp Lys Pro Thr Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Glu Gln
            1140                1145                1150        
His Glu Glu Glu Glu Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu
        1155                1160                1165            
Glu Lys Arg His Val Asp Gln Pro Ile Asp Tyr Ser Leu Lys Tyr Ala
    1170                1175                1180                
Thr Asp Ile Pro Ser Ser Gln Lys Gln Ser Phe Ser Phe Ser Lys Ser
1185                1190                1195                1200
Ser Ser Gly Gln Ser Ser Lys Thr Glu His Met Ser Ser Ser Ser Glu
                1205                1210                1215    
Asn Thr Ser Thr Pro Ser Ser Asn Ala Lys Arg Gln Asn Gln Leu His
            1220                1225                1230        
Pro Ser Ser Ala Gln Ser Arg Ser Gly Gln Pro Gln Lys Ala Ala Thr
        1235                1240                1245            
Cys Lys Val Ser Ser Ile Asn Gln Glu Thr Ile Gln Thr Tyr Cys Val
    1250                1255                1260                
Glu Asp Thr Pro Ile Cys Phe Ser Arg Cys Ser Ser Leu Ser Ser Leu
1265                1270                1275                1280
Ser Ser Ala Glu Asp Glu Ile Gly Cys Asn Gln Thr Thr Gln Glu Ala
                1285                1290                1295    
Asp Ser Ala Asn Thr Leu Gln Ile Ala Glu Ile Lys Glu Lys Ile Gly
            1300                1305                1310        
Thr Arg Ser Ala Glu Asp Pro Val Ser Glu Val Pro Ala Val Ser Gln
        1315                1320                1325            
His Pro Arg Thr Lys Ser Ser Arg Leu Gln Gly Ser Ser Leu Ser Ser
    1330                1335                1340                
Glu Ser Ala Arg His Lys Ala Val Glu Phe Ser Ser Gly Ala Lys Ser
1345                1350                1355                1360
Pro Ser Lys Ser Gly Ala Gln Thr Pro Lys Ser Pro Pro Glu His Tyr
                1365                1370                1375    
Val Gln Glu Thr Pro Leu Met Phe Ser Arg Cys Thr Ser Val Ser Ser
            1380                1385                1390        
Leu Asp Ser Phe Glu Ser Arg Ser Ile Ala Ser Ser Val Gln Ser Glu
        1395                1400                1405            
Pro Cys Ser Gly Met Val Ser Gly Ile Ile Ser Pro Ser Asp Leu Pro
    1410                1415                1420                
Asp Ser Pro Gly Gln Thr Met Pro Pro Ser Arg Ser Lys Thr Pro Pro
1425                1430                1435                1440
Pro Pro Pro Gln Thr Ala Gln Thr Lys Arg Glu Val Pro Lys Asn Lys
                1445                1450                1455    
Ala Pro Thr Ala Glu Lys Arg Glu Ser Gly Pro Lys Gln Ala Ala Val
            1460                1465                1470        
Asn Ala Ala Val Gln Arg Val Gln Val Leu Pro Asp Ala Asp Thr Leu
        1475                1480                1485            
Leu His Phe Ala Thr Glu Ser Thr Pro Asp Gly Phe Ser Cys Ser Ser
    1490                1495                1500                
Ser Leu Ser Ala Leu Ser Leu Asp Glu Pro Phe Ile Gln Lys Asp Val
1505                1510                1515                1520
Glu Leu Arg Ile Met Pro Pro Val Gln Glu Asn Asp Asn Gly Asn Glu
                1525                1530                1535    
Thr Glu Ser Glu Gln Pro Lys Glu Ser Asn Glu Asn Gln Glu Lys Glu
            1540                1545                1550        
Ala Glu Lys Thr Ile Asp Ser Glu Lys Asp Leu Leu Asp Asp Ser Asp
        1555                1560                1565            
Asp Asp Asp Ile Glu Ile Leu Glu Glu Cys Ile Ile Ser Ala Met Pro
    1570                1575                1580                
Thr Lys Ser Ser Arg Lys Ala Lys Lys Pro Ala Gln Thr Ala Ser Lys
1585                1590                1595                1600
Leu Pro Pro Pro Val Ala Arg Lys Pro Ser Gln Leu Pro Val Tyr Lys
                1605                1610                1615    
Leu Leu Pro Ser Gln Asn Arg Leu Gln Pro Gln Lys His Val Ser Phe
            1620                1625                1630        
Thr Pro Gly Asp Asp Met Pro Arg Val Tyr Cys Val Glu Gly Thr Pro
        1635                1640                1645            
Ile Asn Phe Ser Thr Ala Thr Ser Leu Ser Asp Leu Thr Ile Glu Ser
    1650                1655                1660                
Pro Pro Asn Glu Leu Ala Ala Gly Glu Gly Val Arg Gly Gly Ala Gln
1665                1670                1675                1680
Ser Gly Glu Phe Glu Lys Arg Asp Thr Ile Pro Thr Glu Gly Arg Ser
                1685                1690                1695    
Thr Asp Glu Ala Gln Gly Gly Lys Thr Ser Ser Val Thr Ile Pro Glu
            1700                1705                1710        
Leu Asp Asp Asn Lys Ala Glu Glu Gly Asp Ile Leu Ala Glu Cys Ile
        1715                1720                1725            
Asn Ser Ala Met Pro Lys Gly Lys Ser His Lys Pro Phe Arg Val Lys
    1730                1735                1740                
Lys Ile Met Asp Gln Val Gln Gln Ala Ser Ala Ser Ser Ser Ala Pro
1745                1750                1755                1760
Asn Lys Asn Gln Leu Asp Gly Lys Lys Lys Lys Pro Thr Ser Pro Val
                1765                1770                1775    
Lys Pro Ile Pro Gln Asn Thr Glu Tyr Arg Thr Arg Val Arg Lys Asn
            1780                1785                1790        
Ala Asp Ser Lys Asn Asn Leu Asn Ala Glu Arg Val Phe Ser Asp Asn
        1795                1800                1805            
Lys Asp Ser Lys Lys Gln Asn Leu Lys Asn Asn Ser Lys Asp Phe Asn
    1810                1815                1820                
Asp Lys Leu Pro Asn Asn Glu Asp Arg Val Arg Gly Ser Phe Ala Phe
1825                1830                1835                1840
Asp Ser Pro His His Tyr Thr Pro Ile Glu Gly Thr Pro Tyr Cys Phe
                1845                1850                1855    
Ser Arg Asn Asp Ser Leu Ser Ser Leu Asp Phe Asp Asp Asp Asp Val
            1860                1865                1870        
Asp Leu Ser Arg Glu Lys Ala Glu Leu Arg Lys Ala Lys Glu Asn Lys
        1875                1880                1885            
Glu Ser Glu Ala Lys Val Thr Ser His Thr Glu Leu Thr Ser Asn Gln
    1890                1895                1900                
Gln Ser Ala Asn Lys Thr Gln Ala Ile Ala Lys Gln Pro Ile Asn Arg
1905                1910                1915                1920
Gly Gln Pro Lys Pro Ile Leu Gln Lys Gln Ser Thr Phe Pro Gln Ser
                1925                1930                1935    
Ser Lys Asp Ile Pro Asp Arg Gly Ala Ala Thr Asp Glu Lys Leu Gln
            1940                1945                1950        
Asn Phe Ala Ile Glu Asn Thr Pro Val Cys Phe Ser His Asn Ser Ser
        1955                1960                1965            
Leu Ser Ser Leu Ser Asp Ile Asp Gln Glu Asn Asn Asn Lys Glu Asn
    1970                1975                1980                
Glu Pro Ile Lys Glu Thr Glu Pro Pro Asp Ser Gln Gly Glu Pro Ser
1985                1990                1995                2000
Lys Pro Gln Ala Ser Gly Tyr Ala Pro Lys Ser Phe His Val Glu Asp
                2005                2010                2015    
Thr Pro Val Cys Phe Ser Arg Asn Ser Ser Leu Ser Ser Leu Ser Ile
            2020                2025                2030        
Asp Ser Glu Asp Asp Leu Leu Gln Glu Cys Ile Ser Ser Ala Met Pro
        2035                2040                2045            
Lys Lys Lys Lys Pro Ser Arg Leu Lys Gly Asp Asn Glu Lys His Ser
    2050                2055                2060                
Pro Arg Asn Met Gly Gly Ile Leu Gly Glu Asp Leu Thr Leu Asp Leu
2065                2070                2075                2080
Lys Asp Ile Gln Arg Pro Asp Ser Glu His Gly Leu Ser Pro Asp Ser
                2085                2090                2095    
Glu Asn Phe Asp Trp Lys Ala Ile Gln Glu Gly Ala Asn Ser Ile Val
            2100                2105                2110        
Ser Ser Leu His Gln Ala Ala Ala Ala Ala Cys Leu Ser Arg Gln Ala
        2115                2120                2125            
Ser Ser Asp Ser Asp Ser Ile Leu Ser Leu Lys Ser Gly Ile Ser Leu
    2130                2135                2140                
Gly Ser Pro Phe His Leu Thr Pro Asp Gln Glu Glu Lys Pro Phe Thr
2145                2150                2155                2160
Ser Asn Lys Gly Pro Arg Ile Leu Lys Pro Gly Glu Lys Ser Thr Leu
                2165                2170                2175    
Glu Thr Lys Lys Ile Glu Ser Glu Ser Lys Gly Ile Lys Gly Gly Lys
            2180                2185                2190        
Lys Val Tyr Lys Ser Leu Ile Thr Gly Lys Val Arg Ser Asn Ser Glu
        2195                2200                2205            
Ile Ser Gly Gln Met Lys Gln Pro Leu Gln Ala Asn Met Pro Ser Ile
    2210                2215                2220                
Ser Arg Gly Arg Thr Met Ile His Ile Pro Gly Val Arg Asn Ser Ser
2225                2230                2235                2240
Ser Ser Thr Ser Pro Val Ser Lys Lys Gly Pro Pro Leu Lys Thr Pro
                2245                2250                2255    
Ala Ser Lys Ser Pro Ser Glu Gly Gln Thr Ala Thr Thr Ser Pro Arg
            2260                2265                2270        
Gly Ala Lys Pro Ser Val Lys Ser Glu Leu Ser Pro Val Ala Arg Gln
        2275                2280                2285            
Thr Ser Gln Ile Gly Gly Ser Ser Lys Ala Pro Ser Arg Ser Gly Ser
    2290                2295                2300                
Arg Asp Ser Thr Pro Ser Arg Pro Ala Gln Gln Pro Leu Ser Arg Pro
2305                2310                2315                2320
Ile Gln Ser Pro Gly Arg Asn Ser Ile Ser Pro Gly Arg Asn Gly Ile
                2325                2330                2335    
Ser Pro Pro Asn Lys Leu Ser Gln Leu Pro Arg Thr Ser Ser Pro Ser
            2340                2345                2350        
Thr Ala Ser Thr Lys Ser Ser Gly Ser Gly Lys Met Ser Tyr Thr Ser
        2355                2360                2365            
Pro Gly Arg Gln Met Ser Gln Gln Asn Leu Thr Lys Gln Thr Gly Leu
    2370                2375                2380                
Ser Lys Asn Ala Ser Ser Ile Pro Arg Ser Glu Ser Ala Ser Lys Gly
2385                2390                2395                2400
Leu Asn Gln Met Asn Asn Gly Asn Gly Ala Asn Lys Lys Val Glu Leu
                2405                2410                2415    
Ser Arg Met Ser Ser Thr Lys Ser Ser Gly Ser Glu Ser Asp Arg Ser
            2420                2425                2430        
Glu Arg Pro Val Leu Val Arg Gln Ser Thr Phe Ile Lys Glu Ala Pro
        2435                2440                2445            
Ser Pro Thr Leu Arg Arg Lys Leu Glu Glu Ser Ala Ser Phe Glu Ser
    2450                2455                2460                
Leu Ser Pro Ser Ser Arg Pro Ala Ser Pro Thr Arg Ser Gln Ala Gln
2465                2470                2475                2480
Thr Pro Val Leu Ser Pro Ser Leu Pro Asp Met Ser Leu Ser Thr His
                2485                2490                2495    
Ser Ser Val Gln Ala Gly Gly Trp Arg Lys Leu Pro Pro Asn Leu Ser
            2500                2505                2510        
Pro Thr Ile Glu Tyr Asn Asp Gly Arg Pro Ala Lys Arg His Asp Ile
        2515                2520                2525            
Ala Arg Ser His Ser Glu Ser Pro Ser Arg Leu Pro Ile Asn Arg Ser
    2530                2535                2540                
Gly Thr Trp Lys Arg Glu His Ser Lys His Ser Ser Ser Leu Pro Arg
2545                2550                2555                2560
Val Ser Thr Trp Arg Arg Thr Gly Ser Ser Ser Ser Ile Leu Ser Ala
                2565                2570                2575    
Ser Ser Glu Ser Ser Glu Lys Ala Lys Ser Glu Asp Glu Lys His Val
            2580                2585                2590        
Asn Ser Ile Ser Gly Thr Lys Gln Ser Lys Glu Asn Gln Val Ser Ala
        2595                2600                2605            
Lys Gly Thr Trp Arg Lys Ile Lys Glu Asn Glu Phe Ser Pro Thr Asn
    2610                2615                2620                
Ser Thr Ser Gln Thr Val Ser Ser Gly Ala Thr Asn Gly Ala Glu Ser
2625                2630                2635                2640
Lys Thr Leu Ile Tyr Gln Met Ala Pro Ala Val Ser Lys Thr Glu Asp
                2645                2650                2655    
Val Trp Val Arg Ile Glu Asp Cys Pro Ile Asn Asn Pro Arg Ser Gly
            2660                2665                2670        
Arg Ser Pro Thr Gly Asn Thr Pro Pro Val Ile Asp Ser Val Ser Glu
        2675                2680                2685            
Lys Ala Asn Pro Asn Ile Lys Asp Ser Lys Asp Asn Gln Ala Lys Gln
    2690                2695                2700                
Asn Val Gly Asn Gly Ser Val Pro Met Arg Thr Val Gly Leu Glu Asn
2705                2710                2715                2720
Arg Leu Asn Ser Phe Ile Gln Val Asp Ala Pro Asp Gln Lys Gly Thr
                2725                2730                2735    
Glu Ile Lys Pro Gly Gln Asn Asn Pro Val Pro Val Ser Glu Thr Asn
            2740                2745                2750        
Glu Ser Ser Ile Val Glu Arg Thr Pro Phe Ser Ser Ser Ser Ser Ser
        2755                2760                2765            
Lys His Ser Ser Pro Ser Gly Thr Val Ala Ala Arg Val Thr Pro Phe
    2770                2775                2780                
Asn Tyr Asn Pro Ser Pro Arg Lys Ser Ser Ala Asp Ser Thr Ser Ala
2785                2790                2795                2800
Arg Pro Ser Gln Ile Pro Thr Pro Val Asn Asn Asn Thr Lys Lys Arg
                2805                2810                2815    
Asp Ser Lys Thr Asp Ser Thr Glu Ser Ser Gly Thr Gln Ser Pro Lys
            2820                2825                2830        
Arg His Ser Gly Ser Tyr Leu Val Thr Ser Val
        2835                2840            


<210> 7294
<211> 2742
<212> PRT
<213> Homo sapiens

<400> 7294
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu
 1               5                  10                  15      
Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn
            20                  25                  30          
His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu
        35                  40                  45              
Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly
    50                  55                  60                  
Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser
65                  70                  75                  80  
Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr
                85                  90                  95      
Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro
            100                 105                 110         
Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg
        115                 120                 125             
Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu
    130                 135                 140                 
Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala
145                 150                 155                 160 
Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu
                165                 170                 175     
Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu
            180                 185                 190         
Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln
        195                 200                 205             
Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile
    210                 215                 220                 
Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr
225                 230                 235                 240 
Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp
                245                 250                 255     
Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala
            260                 265                 270         
Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr
        275                 280                 285             
Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu
    290                 295                 300                 
Thr Ser His Leu Gly Thr Lys Ile Arg Ala Tyr Cys Glu Thr Cys Trp
305                 310                 315                 320 
Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp Gln Asp Lys Asn Pro
                325                 330                 335     
Met Pro Ala Pro Val Glu His Gln Ile Cys Pro Ala Val Cys Val Leu
            340                 345                 350         
Met Lys Leu Ser Phe Asp Glu Glu His Arg His Ala Met Asn Glu Leu
        355                 360                 365             
Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln Val Asp Cys Glu Met
    370                 375                 380                 
Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr Leu Arg Arg Tyr Ala
385                 390                 395                 400 
Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp Val Ala Asn Lys Ala
                405                 410                 415     
Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala Leu Val Ala Gln Leu
            420                 425                 430         
Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile Ala Ser Val Leu Arg
        435                 440                 445             
Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys Lys Thr Leu Arg Glu
    450                 455                 460                 
Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala Leu Glu Val Lys Lys
465                 470                 475                 480 
Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu Trp Asn Leu Ser Ala
                485                 490                 495     
His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala Val Asp Gly Ala Leu
            500                 505                 510         
Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser Gln Thr Asn Thr Leu
        515                 520                 525             
Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val Ser Ser Leu
    530                 535                 540                 
Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu Arg Glu Asn Asn Cys
545                 550                 555                 560 
Leu Gln Thr Leu Leu Gln His Leu Lys Ser His Ser Leu Thr Ile Val
                565                 570                 575     
Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser Ala Arg Asn Pro Lys
            580                 585                 590         
Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val Ser Met Leu Lys Asn
        595                 600                 605             
Leu Ile His Ser Lys His Lys Met Ile Ala Met Gly Ser Ala Ala Ala
    610                 615                 620                 
Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys Tyr Lys Asp Ala Asn
625                 630                 635                 640 
Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu His Val Arg Lys Gln
                645                 650                 655     
Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His Leu Ser Glu Thr Phe
            660                 665                 670         
Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser His Arg Ser Lys Gln
        675                 680                 685             
Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val Phe Asp Thr Asn Arg
    690                 695                 700                 
His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr Gly Asn Met Thr Val
705                 710                 715                 720 
Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro Ser Ser Ser Ser Ser
                725                 730                 735     
Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys Asp Arg Ser Leu Glu
            740                 745                 750         
Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His Pro Ala Thr Glu Asn
        755                 760                 765             
Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile Ser Thr Thr Ala Ala
    770                 775                 780                 
Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala Ile His Thr Ser Gln
785                 790                 795                 800 
Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu His Cys Val Thr Asp
                805                 810                 815     
Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala His Thr His Ser Asn
            820                 825                 830         
Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn Arg Thr Cys Ser Met
        835                 840                 845             
Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser Asn Asp Ser Leu Asn
    850                 855                 860                 
Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg Gly Gln Met Lys Pro
865                 870                 875                 880 
Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser Lys Phe Cys Ser Tyr
                885                 890                 895     
Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile His Ser Ala Asn His
            900                 905                 910         
Met Asp Asp Asn Asp Gly Glu Leu Asp Thr Pro Ile Asn Tyr Ser Leu
        915                 920                 925             
Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg Gln Ser Pro Ser Gln
    930                 935                 940                 
Asn Glu Arg Trp Ala Arg Pro Lys His Ile Ile Glu Asp Glu Ile Lys
945                 950                 955                 960 
Gln Ser Glu Gln Arg Gln Ser Arg Asn Gln Ser Thr Thr Tyr Pro Val
                965                 970                 975     
Tyr Thr Glu Ser Thr Asp Asp Lys His Leu Lys Phe Gln Pro His Phe
            980                 985                 990         
Gly Gln Gln Glu Cys Val Ser Pro Tyr Arg Ser Arg Gly Ala Asn Gly
        995                 1000                1005            
Ser Glu Thr Asn Arg Val Gly Ser Asn His Gly Ile Asn Gln Asn Val
    1010                1015                1020                
Ser Gln Ser Leu Cys Gln Glu Asp Asp Tyr Glu Asp Asp Lys Pro Thr
1025                1030                1035                1040
Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Glu Gln His Glu Glu Glu Glu
                1045                1050                1055    
Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu Glu Lys Arg His Val
            1060                1065                1070        
Asp Gln Pro Ile Asp Tyr Ser Leu Lys Tyr Ala Thr Asp Ile Pro Ser
        1075                1080                1085            
Ser Gln Lys Gln Ser Phe Ser Phe Ser Lys Ser Ser Ser Gly Gln Ser
    1090                1095                1100                
Ser Lys Thr Glu His Met Ser Ser Ser Ser Glu Asn Thr Ser Thr Pro
1105                1110                1115                1120
Ser Ser Asn Ala Lys Arg Gln Asn Gln Leu His Pro Ser Ser Ala Gln
                1125                1130                1135    
Ser Arg Ser Gly Gln Pro Gln Lys Ala Ala Thr Cys Lys Val Ser Ser
            1140                1145                1150        
Ile Asn Gln Glu Thr Ile Gln Thr Tyr Cys Val Glu Asp Thr Pro Ile
        1155                1160                1165            
Cys Phe Ser Arg Cys Ser Ser Leu Ser Ser Leu Ser Ser Ala Glu Asp
    1170                1175                1180                
Glu Ile Gly Cys Asn Gln Thr Thr Gln Glu Ala Asp Ser Ala Asn Thr
1185                1190                1195                1200
Leu Gln Ile Ala Glu Ile Lys Glu Lys Ile Gly Thr Arg Ser Ala Glu
                1205                1210                1215    
Asp Pro Val Ser Glu Val Pro Ala Val Ser Gln His Pro Arg Thr Lys
            1220                1225                1230        
Ser Ser Arg Leu Gln Gly Ser Ser Leu Ser Ser Glu Ser Ala Arg His
        1235                1240                1245            
Lys Ala Val Glu Phe Ser Ser Gly Ala Lys Ser Pro Ser Lys Ser Gly
    1250                1255                1260                
Ala Gln Thr Pro Lys Ser Pro Pro Glu His Tyr Val Gln Glu Thr Pro
1265                1270                1275                1280
Leu Met Phe Ser Arg Cys Thr Ser Val Ser Ser Leu Asp Ser Phe Glu
                1285                1290                1295    
Ser Arg Ser Ile Ala Ser Ser Val Gln Ser Glu Pro Cys Ser Gly Met
            1300                1305                1310        
Val Ser Gly Ile Ile Ser Pro Ser Asp Leu Pro Asp Ser Pro Gly Gln
        1315                1320                1325            
Thr Met Pro Pro Ser Arg Ser Lys Thr Pro Pro Pro Pro Pro Gln Thr
    1330                1335                1340                
Ala Gln Thr Lys Arg Glu Val Pro Lys Asn Lys Ala Pro Thr Ala Glu
1345                1350                1355                1360
Lys Arg Glu Ser Gly Pro Lys Gln Ala Ala Val Asn Ala Ala Val Gln
                1365                1370                1375    
Arg Val Gln Val Leu Pro Asp Ala Asp Thr Leu Leu His Phe Ala Thr
            1380                1385                1390        
Glu Ser Thr Pro Asp Gly Phe Ser Cys Ser Ser Ser Leu Ser Ala Leu
        1395                1400                1405            
Ser Leu Asp Glu Pro Phe Ile Gln Lys Asp Val Glu Leu Arg Ile Met
    1410                1415                1420                
Pro Pro Val Gln Glu Asn Asp Asn Gly Asn Glu Thr Glu Ser Glu Gln
1425                1430                1435                1440
Pro Lys Glu Ser Asn Glu Asn Gln Glu Lys Glu Ala Glu Lys Thr Ile
                1445                1450                1455    
Asp Ser Glu Lys Asp Leu Leu Asp Asp Ser Asp Asp Asp Asp Ile Glu
            1460                1465                1470        
Ile Leu Glu Glu Cys Ile Ile Ser Ala Met Pro Thr Lys Ser Ser Arg
        1475                1480                1485            
Lys Ala Lys Lys Pro Ala Gln Thr Ala Ser Lys Leu Pro Pro Pro Val
    1490                1495                1500                
Ala Arg Lys Pro Ser Gln Leu Pro Val Tyr Lys Leu Leu Pro Ser Gln
1505                1510                1515                1520
Asn Arg Leu Gln Pro Gln Lys His Val Ser Phe Thr Pro Gly Asp Asp
                1525                1530                1535    
Met Pro Arg Val Tyr Cys Val Glu Gly Thr Pro Ile Asn Phe Ser Thr
            1540                1545                1550        
Ala Thr Ser Leu Ser Asp Leu Thr Ile Glu Ser Pro Pro Asn Glu Leu
        1555                1560                1565            
Ala Ala Gly Glu Gly Val Arg Gly Gly Ala Gln Ser Gly Glu Phe Glu
    1570                1575                1580                
Lys Arg Asp Thr Ile Pro Thr Glu Gly Arg Ser Thr Asp Glu Ala Gln
1585                1590                1595                1600
Gly Gly Lys Thr Ser Ser Val Thr Ile Pro Glu Leu Asp Asp Asn Lys
                1605                1610                1615    
Ala Glu Glu Gly Asp Ile Leu Ala Glu Cys Ile Asn Ser Ala Met Pro
            1620                1625                1630        
Lys Gly Lys Ser His Lys Pro Phe Arg Val Lys Lys Ile Met Asp Gln
        1635                1640                1645            
Val Gln Gln Ala Ser Ala Ser Ser Ser Ala Pro Asn Lys Asn Gln Leu
    1650                1655                1660                
Asp Gly Lys Lys Lys Lys Pro Thr Ser Pro Val Lys Pro Ile Pro Gln
1665                1670                1675                1680
Asn Thr Glu Tyr Arg Thr Arg Val Arg Lys Asn Ala Asp Ser Lys Asn
                1685                1690                1695    
Asn Leu Asn Ala Glu Arg Val Phe Ser Asp Asn Lys Asp Ser Lys Lys
            1700                1705                1710        
Gln Asn Leu Lys Asn Asn Ser Lys Asp Phe Asn Asp Lys Leu Pro Asn
        1715                1720                1725            
Asn Glu Asp Arg Val Arg Gly Ser Phe Ala Phe Asp Ser Pro His His
    1730                1735                1740                
Tyr Thr Pro Ile Glu Gly Thr Pro Tyr Cys Phe Ser Arg Asn Asp Ser
1745                1750                1755                1760
Leu Ser Ser Leu Asp Phe Asp Asp Asp Asp Val Asp Leu Ser Arg Glu
                1765                1770                1775    
Lys Ala Glu Leu Arg Lys Ala Lys Glu Asn Lys Glu Ser Glu Ala Lys
            1780                1785                1790        
Val Thr Ser His Thr Glu Leu Thr Ser Asn Gln Gln Ser Ala Asn Lys
        1795                1800                1805            
Thr Gln Ala Ile Ala Lys Gln Pro Ile Asn Arg Gly Gln Pro Lys Pro
    1810                1815                1820                
Ile Leu Gln Lys Gln Ser Thr Phe Pro Gln Ser Ser Lys Asp Ile Pro
1825                1830                1835                1840
Asp Arg Gly Ala Ala Thr Asp Glu Lys Leu Gln Asn Phe Ala Ile Glu
                1845                1850                1855    
Asn Thr Pro Val Cys Phe Ser His Asn Ser Ser Leu Ser Ser Leu Ser
            1860                1865                1870        
Asp Ile Asp Gln Glu Asn Asn Asn Lys Glu Asn Glu Pro Ile Lys Glu
        1875                1880                1885            
Thr Glu Pro Pro Asp Ser Gln Gly Glu Pro Ser Lys Pro Gln Ala Ser
    1890                1895                1900                
Gly Tyr Ala Pro Lys Ser Phe His Val Glu Asp Thr Pro Val Cys Phe
1905                1910                1915                1920
Ser Arg Asn Ser Ser Leu Ser Ser Leu Ser Ile Asp Ser Glu Asp Asp
                1925                1930                1935    
Leu Leu Gln Glu Cys Ile Ser Ser Ala Met Pro Lys Lys Lys Lys Pro
            1940                1945                1950        
Ser Arg Leu Lys Gly Asp Asn Glu Lys His Ser Pro Arg Asn Met Gly
        1955                1960                1965            
Gly Ile Leu Gly Glu Asp Leu Thr Leu Asp Leu Lys Asp Ile Gln Arg
    1970                1975                1980                
Pro Asp Ser Glu His Gly Leu Ser Pro Asp Ser Glu Asn Phe Asp Trp
1985                1990                1995                2000
Lys Ala Ile Gln Glu Gly Ala Asn Ser Ile Val Ser Ser Leu His Gln
                2005                2010                2015    
Ala Ala Ala Ala Ala Cys Leu Ser Arg Gln Ala Ser Ser Asp Ser Asp
            2020                2025                2030        
Ser Ile Leu Ser Leu Lys Ser Gly Ile Ser Leu Gly Ser Pro Phe His
        2035                2040                2045            
Leu Thr Pro Asp Gln Glu Glu Lys Pro Phe Thr Ser Asn Lys Gly Pro
    2050                2055                2060                
Arg Ile Leu Lys Pro Gly Glu Lys Ser Thr Leu Glu Thr Lys Lys Ile
2065                2070                2075                2080
Glu Ser Glu Ser Lys Gly Ile Lys Gly Gly Lys Lys Val Tyr Lys Ser
                2085                2090                2095    
Leu Ile Thr Gly Lys Val Arg Ser Asn Ser Glu Ile Ser Gly Gln Met
            2100                2105                2110        
Lys Gln Pro Leu Gln Ala Asn Met Pro Ser Ile Ser Arg Gly Arg Thr
        2115                2120                2125            
Met Ile His Ile Pro Gly Val Arg Asn Ser Ser Ser Ser Thr Ser Pro
    2130                2135                2140                
Val Ser Lys Lys Gly Pro Pro Leu Lys Thr Pro Ala Ser Lys Ser Pro
2145                2150                2155                2160
Ser Glu Gly Gln Thr Ala Thr Thr Ser Pro Arg Gly Ala Lys Pro Ser
                2165                2170                2175    
Val Lys Ser Glu Leu Ser Pro Val Ala Arg Gln Thr Ser Gln Ile Gly
            2180                2185                2190        
Gly Ser Ser Lys Ala Pro Ser Arg Ser Gly Ser Arg Asp Ser Thr Pro
        2195                2200                2205            
Ser Arg Pro Ala Gln Gln Pro Leu Ser Arg Pro Ile Gln Ser Pro Gly
    2210                2215                2220                
Arg Asn Ser Ile Ser Pro Gly Arg Asn Gly Ile Ser Pro Pro Asn Lys
2225                2230                2235                2240
Leu Ser Gln Leu Pro Arg Thr Ser Ser Pro Ser Thr Ala Ser Thr Lys
                2245                2250                2255    
Ser Ser Gly Ser Gly Lys Met Ser Tyr Thr Ser Pro Gly Arg Gln Met
            2260                2265                2270        
Ser Gln Gln Asn Leu Thr Lys Gln Thr Gly Leu Ser Lys Asn Ala Ser
        2275                2280                2285            
Ser Ile Pro Arg Ser Glu Ser Ala Ser Lys Gly Leu Asn Gln Met Asn
    2290                2295                2300                
Asn Gly Asn Gly Ala Asn Lys Lys Val Glu Leu Ser Arg Met Ser Ser
2305                2310                2315                2320
Thr Lys Ser Ser Gly Ser Glu Ser Asp Arg Ser Glu Arg Pro Val Leu
                2325                2330                2335    
Val Arg Gln Ser Thr Phe Ile Lys Glu Ala Pro Ser Pro Thr Leu Arg
            2340                2345                2350        
Arg Lys Leu Glu Glu Ser Ala Ser Phe Glu Ser Leu Ser Pro Ser Ser
        2355                2360                2365            
Arg Pro Ala Ser Pro Thr Arg Ser Gln Ala Gln Thr Pro Val Leu Ser
    2370                2375                2380                
Pro Ser Leu Pro Asp Met Ser Leu Ser Thr His Ser Ser Val Gln Ala
2385                2390                2395                2400
Gly Gly Trp Arg Lys Leu Pro Pro Asn Leu Ser Pro Thr Ile Glu Tyr
                2405                2410                2415    
Asn Asp Gly Arg Pro Ala Lys Arg His Asp Ile Ala Arg Ser His Ser
            2420                2425                2430        
Glu Ser Pro Ser Arg Leu Pro Ile Asn Arg Ser Gly Thr Trp Lys Arg
        2435                2440                2445            
Glu His Ser Lys His Ser Ser Ser Leu Pro Arg Val Ser Thr Trp Arg
    2450                2455                2460                
Arg Thr Gly Ser Ser Ser Ser Ile Leu Ser Ala Ser Ser Glu Ser Ser
2465                2470                2475                2480
Glu Lys Ala Lys Ser Glu Asp Glu Lys His Val Asn Ser Ile Ser Gly
                2485                2490                2495    
Thr Lys Gln Ser Lys Glu Asn Gln Val Ser Ala Lys Gly Thr Trp Arg
            2500                2505                2510        
Lys Ile Lys Glu Asn Glu Phe Ser Pro Thr Asn Ser Thr Ser Gln Thr
        2515                2520                2525            
Val Ser Ser Gly Ala Thr Asn Gly Ala Glu Ser Lys Thr Leu Ile Tyr
    2530                2535                2540                
Gln Met Ala Pro Ala Val Ser Lys Thr Glu Asp Val Trp Val Arg Ile
2545                2550                2555                2560
Glu Asp Cys Pro Ile Asn Asn Pro Arg Ser Gly Arg Ser Pro Thr Gly
                2565                2570                2575    
Asn Thr Pro Pro Val Ile Asp Ser Val Ser Glu Lys Ala Asn Pro Asn
            2580                2585                2590        
Ile Lys Asp Ser Lys Asp Asn Gln Ala Lys Gln Asn Val Gly Asn Gly
        2595                2600                2605            
Ser Val Pro Met Arg Thr Val Gly Leu Glu Asn Arg Leu Asn Ser Phe
    2610                2615                2620                
Ile Gln Val Asp Ala Pro Asp Gln Lys Gly Thr Glu Ile Lys Pro Gly
2625                2630                2635                2640
Gln Asn Asn Pro Val Pro Val Ser Glu Thr Asn Glu Ser Ser Ile Val
                2645                2650                2655    
Glu Arg Thr Pro Phe Ser Ser Ser Ser Ser Ser Lys His Ser Ser Pro
            2660                2665                2670        
Ser Gly Thr Val Ala Ala Arg Val Thr Pro Phe Asn Tyr Asn Pro Ser
        2675                2680                2685            
Pro Arg Lys Ser Ser Ala Asp Ser Thr Ser Ala Arg Pro Ser Gln Ile
    2690                2695                2700                
Pro Thr Pro Val Asn Asn Asn Thr Lys Lys Arg Asp Ser Lys Thr Asp
2705                2710                2715                2720
Ser Thr Glu Ser Ser Gly Thr Gln Ser Pro Lys Arg His Ser Gly Ser
                2725                2730                2735    
Tyr Leu Val Thr Ser Val
            2740        


<210> 7295
<211> 900
<212> PRT
<213> Homo sapiens

<400> 7295
Met Ser Ser Lys Glu Ser Cys Gly Lys Lys Glu Thr Ser Gln Arg Lys
 1               5                  10                  15      
Asp Thr Thr Thr Ser Ser Pro Asn Phe Gly Glu Lys Asp Lys Lys Glu
            20                  25                  30          
Arg Lys Thr Pro Ala Ser Ser Thr Ser Ser Ser Ser Ile Arg Ser Val
        35                  40                  45              
Ser Ser Glu Lys Arg Lys Leu Lys Ser Asp His Thr Asp Val Leu Tyr
    50                  55                  60                  
Tyr Asn Ile Lys Arg Arg Gln Gly Leu Lys Arg Leu Ser Val Glu Ile
65                  70                  75                  80  
Asp Thr Leu Arg Arg Arg Pro Lys Ile Gly Ser Ser Ser Gln Arg Pro
                85                  90                  95      
Ile Lys Leu Lys Glu Ala Ser Tyr Ser Asn Asp Asn Gln Ile Ile Leu
            100                 105                 110         
Gln Ser Pro Ser Ser Asn Gly Thr Lys Lys Asp Ile His Lys Cys Val
        115                 120                 125             
Asp Phe Lys Pro Lys Asp Ile Lys Leu Thr Asn Ala Gly Ser Lys Leu
    130                 135                 140                 
Asp His Gly Val Lys Ser Leu Ser Ser Pro Lys Ile Ala Ser Asp Val
145                 150                 155                 160 
Lys Pro Lys Ala Glu Gly Gln Ala Ser Glu Asn Lys Trp Ser His Leu
                165                 170                 175     
Leu Val Gln Arg Glu Lys Met Lys Glu Leu Lys Lys Gly Arg Asn Ser
            180                 185                 190         
Lys Phe Arg Asp Asn Ser Glu Lys Cys Val Leu Glu Lys Trp Lys Arg
        195                 200                 205             
Asn Gln Phe Ser Gln Asp Tyr Asn Ser Asn Lys Ile Ile Lys Glu Pro
    210                 215                 220                 
Leu Gly Ser Arg Arg Gln Lys Ile Ser Phe Lys Ile Pro Ile Lys Ser
225                 230                 235                 240 
Arg Asp Thr Leu Gln Lys Leu Val Glu Glu Asn Val Phe Asn Ile Asp
                245                 250                 255     
Ser Asn Asn Ser Lys Thr Lys Gln Glu Glu Arg Glu Tyr Leu Glu Ser
            260                 265                 270         
Ser Gln Val Ser Leu Asn Val Thr Arg Gln Lys Thr Glu His Leu Leu
        275                 280                 285             
Ser Asp Phe Thr Tyr Lys Arg Thr Val His Glu Trp Lys Arg Lys His
    290                 295                 300                 
His Tyr Asp His Gln Glu Ser Asn Asp Ser His Ser Arg Glu Asn Leu
305                 310                 315                 320 
Thr Gln Ser Phe Glu Ala Pro Cys Cys Ser Val Ser Ser Glu Ser Ile
                325                 330                 335     
Gln Asp Ala Asp Gln Glu Met Gln Ile Val Glu Glu Leu His Ala Ala
            340                 345                 350         
Arg Val Gly Lys Ser Val Asp Leu Pro Gly Glu Leu Met Ser Met Glu
        355                 360                 365             
Ile Asp Leu Glu Asp Asp Val His Ser Ser Ser Ala Asn Asn Thr Ser
    370                 375                 380                 
Asp Arg Lys Leu Leu Ile Val Ile Asp Thr Asn Ile Leu Met Asn His
385                 390                 395                 400 
Leu Lys Phe Val Arg Ile Leu Lys Thr Thr Glu Val Pro Gly Phe Asp
                405                 410                 415     
Lys Leu Val Leu Ile Ile Pro Trp Val Val Met Gln Glu Leu Asp Arg
            420                 425                 430         
Met Lys Glu Gly Lys Leu Leu Lys Arg Ala Gln His Lys Ala Ile Pro
        435                 440                 445             
Ala Val His Phe Ile Asn Asp Ser Leu Lys Asn Gln Asp Arg Lys Leu
    450                 455                 460                 
Trp Gly Gln Ser Ile Gln Leu Ala Ser Gln Lys His Tyr Gly Leu Ser
465                 470                 475                 480 
Asp Glu Asn Asn Asp Asp Arg Val Leu Lys Cys Cys Leu Gln His Gln
                485                 490                 495     
Glu Leu Phe Pro Cys Ser Phe Val Ile Leu Cys Thr Asp Asp Arg Asn
            500                 505                 510         
Leu Arg Asn Lys Gly Leu Ile Ser Gly Val Lys Ser Leu Ser Lys Glu
        515                 520                 525             
Glu Leu Ser Ala Glu Leu Leu Arg Leu Ser Leu Asn Thr Asp Val Cys
    530                 535                 540                 
His Gln Pro Cys Ile Pro Lys Gln Gln Leu Lys Ala Glu Thr Thr Pro
545                 550                 555                 560 
Leu Lys Glu Ser Tyr Lys Glu Glu Ser Thr Ser Ser Gly Leu Ser Ile
                565                 570                 575     
Leu Leu Glu Ser Ile Val Ser Asp Leu Glu Lys Ser Leu Gly Thr Gly
            580                 585                 590         
Leu Ser Ser Ile Leu Glu Thr Glu Met Lys Ile Ala Phe Gly Asn Leu
        595                 600                 605             
Trp Met Glu Ile Leu Tyr Leu Lys Pro Pro Trp Thr Leu Leu His Leu
    610                 615                 620                 
Leu Gln Cys Phe Lys Lys His Trp Leu Ala Val Phe Gly Leu Val Met
625                 630                 635                 640 
Glu Lys Asn Leu Leu Leu Thr Ile Glu Ser Leu Tyr Lys Asn Leu Arg
                645                 650                 655     
Lys Ala Asn Lys Ala Val Asp Phe Thr Thr Val Lys Phe Leu Leu Gln
            660                 665                 670         
Asp Ser Arg Ser Leu Leu His Ala Phe Ser Thr Arg Ser Asn Tyr Asp
        675                 680                 685             
Gly Ile Leu Pro Gln Thr Phe Ala Gln Val Asn Asn Leu Leu Gln Thr
    690                 695                 700                 
Phe Ala Glu Val Lys Thr Lys Leu Lys Pro Asn Ser Ser Glu Asn Thr
705                 710                 715                 720 
Val Thr Lys Lys Gln Glu Gly Thr Ser Leu Lys Asn Ser His Asn Gln
                725                 730                 735     
Glu Ile Thr Val Phe Ser Ser Ser His Leu Pro Gln Pro Ser Arg His
            740                 745                 750         
Gln Glu Ile Trp Ser Ile Leu Glu Ser Val Trp Ile Thr Ile Tyr Gln
        755                 760                 765             
Asn Ser Thr Asp Val Phe Gln Arg Leu Gly Ser Asn Ser Ala Leu Thr
    770                 775                 780                 
Thr Ser Asn Ile Ala Ser Phe Glu Glu Ala Phe Ile Cys Leu Gln Lys
785                 790                 795                 800 
Leu Met Ala Ala Val Arg Asp Ile Leu Glu Gly Ile Gln Arg Ile Leu
                805                 810                 815     
Ala Pro Asn Ser Asp Tyr Gln Asp Val Glu Thr Leu Tyr Asn Phe Leu
            820                 825                 830         
Ile Lys Tyr Glu Val Asn Lys Asn Val Lys Phe Thr Ala Gln Glu Ile
        835                 840                 845             
Tyr Asp Cys Val Ser Gln Thr Glu Tyr Arg Glu Lys Leu Thr Ile Gly
    850                 855                 860                 
Cys Arg Gln Leu Val Glu Met Glu Tyr Thr Met Gln Gln Cys Asn Ala
865                 870                 875                 880 
Ser Val Tyr Met Glu Ala Lys Asn Arg Gly Trp Cys Glu Asp Met Leu
                885                 890                 895     
Asn Tyr Arg Ile
            900 


<210> 7296
<211> 888
<212> PRT
<213> Homo sapiens

<400> 7296
Met Ala Gly Ala Ala Ala Glu Ser Gly Arg Glu Leu Trp Thr Phe Ala
 1               5                  10                  15      
Gly Ser Arg Asp Pro Ser Ala Pro Arg Leu Ala Tyr Gly Tyr Gly Pro
            20                  25                  30          
Gly Ser Leu Arg Glu Leu Arg Ala Arg Glu Phe Ser Arg Leu Ala Gly
        35                  40                  45              
Thr Val Tyr Leu Asp His Ala Gly Ala Thr Leu Phe Ser Gln Ser Gln
    50                  55                  60                  
Leu Glu Ser Phe Thr Ser Asp Leu Met Glu Asn Thr Tyr Gly Asn Pro
65                  70                  75                  80  
His Ser Gln Asn Ile Ser Ser Lys Leu Thr His Asp Thr Val Glu Gln
                85                  90                  95      
Val Arg Tyr Arg Ile Leu Ala His Phe His Thr Thr Ala Glu Asp Tyr
            100                 105                 110         
Thr Val Ile Phe Thr Ala Gly Ser Thr Ala Ala Leu Lys Leu Val Ala
        115                 120                 125             
Glu Ala Phe Pro Trp Val Ser Gln Gly Pro Glu Ser Ser Gly Ser Arg
    130                 135                 140                 
Phe Cys Tyr Leu Thr Asp Ser His Thr Ser Val Val Gly Met Arg Asn
145                 150                 155                 160 
Val Thr Met Ala Ile Asn Val Ile Ser Ile Pro Val Arg Pro Glu Asp
                165                 170                 175     
Leu Trp Ser Ala Glu Glu Arg Gly Ala Ser Ala Ser Asn Pro Asp Cys
            180                 185                 190         
Gln Leu Pro His Leu Phe Cys Tyr Pro Ala Gln Ser Asn Phe Ser Gly
        195                 200                 205             
Val Arg Tyr Pro Leu Ser Trp Ile Glu Glu Val Lys Ser Gly Arg Leu
    210                 215                 220                 
Arg Pro Val Ser Thr Pro Gly Lys Trp Phe Val Leu Leu Asp Ala Ala
225                 230                 235                 240 
Ser Tyr Val Ser Thr Ser Pro Leu Asp Leu Ser Ala His Gln Ala Asp
                245                 250                 255     
Phe Val Pro Ile Ser Phe Tyr Lys Ile Phe Gly Phe Pro Thr Gly Leu
            260                 265                 270         
Gly Ala Leu Leu Val His Asn Arg Ala Ala Pro Leu Leu Arg Lys Thr
        275                 280                 285             
Tyr Phe Gly Gly Gly Thr Ala Ser Ala Tyr Leu Ala Gly Glu Asp Phe
    290                 295                 300                 
Tyr Ile Pro Arg Gln Ser Val Ala Gln Arg Phe Glu Asp Gly Thr Ile
305                 310                 315                 320 
Ser Phe Leu Asp Val Ile Ala Leu Lys His Gly Phe Asp Thr Leu Glu
                325                 330                 335     
Arg Leu Thr Gly Gly Met Glu Asn Ile Lys Gln His Thr Phe Thr Leu
            340                 345                 350         
Ala Gln Tyr Thr Tyr Met Ala Leu Ser Ser Leu Gln Tyr Pro Asn Gly
        355                 360                 365             
Ala Pro Val Val Arg Ile Tyr Ser Asp Ser Glu Phe Ser Ser Pro Glu
    370                 375                 380                 
Val Gln Gly Pro Ile Ile Asn Phe Asn Val Leu Asp Asp Lys Gly Asn
385                 390                 395                 400 
Ile Ile Gly Tyr Ser Gln Val Asp Lys Met Ala Ser Leu Tyr Asn Ile
                405                 410                 415     
His Leu Arg Thr Gly Cys Phe Cys Asn Thr Gly Ala Cys Gln Arg His
            420                 425                 430         
Leu Gly Ile Ser Asn Glu Met Val Arg Lys His Phe Gln Ala Gly His
        435                 440                 445             
Val Cys Gly Asp Asn Met Asp Leu Ile Asp Gly Gln Pro Thr Gly Ser
    450                 455                 460                 
Val Arg Ile Ser Phe Gly Tyr Met Ser Thr Leu Asp Asp Val Gln Ala
465                 470                 475                 480 
Phe Leu Arg Phe Ile Ile Asp Thr Arg Leu His Ser Ser Gly Asp Trp
                485                 490                 495     
Pro Val Pro Gln Ala His Ala Asp Thr Gly Glu Thr Gly Ala Pro Ser
            500                 505                 510         
Ala Asp Ser Gln Ala Asp Val Ile Pro Ala Val Met Gly Arg Arg Ser
        515                 520                 525             
Leu Ser Pro Gln Glu Asp Ala Leu Thr Gly Ser Arg Val Trp Asn Asn
    530                 535                 540                 
Ser Ser Thr Val Asn Ala Val Pro Val Ala Pro Pro Val Cys Asp Val
545                 550                 555                 560 
Ala Arg Thr Gln Pro Thr Pro Ser Glu Lys Ala Ala Gly Val Leu Glu
                565                 570                 575     
Gly Ala Leu Gly Pro His Val Val Thr Asn Leu Tyr Leu Tyr Pro Ile
            580                 585                 590         
Lys Ser Cys Ala Ala Phe Glu Val Thr Arg Trp Pro Val Gly Asn Gln
        595                 600                 605             
Gly Leu Leu Tyr Asp Arg Ser Trp Met Val Val Asn His Asn Gly Val
    610                 615                 620                 
Cys Leu Ser Gln Lys Gln Glu Pro Arg Leu Cys Leu Ile Gln Pro Phe
625                 630                 635                 640 
Ile Asp Leu Arg Gln Arg Ile Met Val Ile Lys Ala Lys Gly Met Glu
                645                 650                 655     
Pro Ile Glu Val Pro Leu Glu Glu Asn Ser Glu Arg Thr Gln Ile Arg
            660                 665                 670         
Gln Ser Arg Val Cys Ala Asp Arg Val Ser Thr Tyr Asp Cys Gly Glu
        675                 680                 685             
Lys Ile Ser Ser Trp Leu Ser Thr Phe Phe Gly Arg Pro Cys His Leu
    690                 695                 700                 
Ile Lys Gln Ser Ser Asn Ser Gln Arg Asn Ala Lys Lys Lys His Gly
705                 710                 715                 720 
Lys Asp Gln Leu Pro Gly Thr Met Ala Thr Leu Ser Leu Val Asn Glu
                725                 730                 735     
Ala Gln Tyr Leu Leu Ile Asn Thr Ser Ser Ile Leu Glu Leu His Arg
            740                 745                 750         
Gln Leu Asn Thr Ser Asp Glu Asn Gly Lys Glu Glu Leu Phe Ser Leu
        755                 760                 765             
Lys Asp Leu Ser Leu Arg Phe Arg Ala Asn Ile Ile Ile Asn Gly Lys
    770                 775                 780                 
Arg Ala Phe Glu Glu Glu Lys Trp Asp Glu Ile Ser Ile Gly Ser Leu
785                 790                 795                 800 
Arg Phe Gln Val Leu Gly Pro Cys His Arg Cys Gln Met Ile Cys Ile
                805                 810                 815     
Asp Gln Gln Thr Gly Gln Arg Asn Gln His Val Phe Gln Lys Leu Ser
            820                 825                 830         
Glu Ser Arg Glu Thr Lys Val Asn Phe Gly Met Tyr Leu Met His Ala
        835                 840                 845             
Ser Leu Asp Leu Ser Ser Pro Cys Phe Leu Ser Val Gly Ser Gln Val
    850                 855                 860                 
Leu Pro Val Leu Lys Glu Asn Val Glu Gly His Asp Leu Pro Ala Ser
865                 870                 875                 880 
Glu Lys His Gln Asp Val Thr Ser
                885             


<210> 7297
<211> 650
<212> PRT
<213> Homo sapiens

<400> 7297
Ser Asp Thr Asn Ile Phe Asp Ser Asn Val Pro Ser Asn Lys Ser Asn
 1               5                  10                  15      
Phe Ser Arg Gly Asp Glu Arg Arg His Glu Ala Ala Val Pro Pro Leu
            20                  25                  30          
Ala Ile Pro Ser Ala Arg Pro Glu Lys Arg Asp Ser Arg Val Ser Thr
        35                  40                  45              
Ser Ser Gln Glu Ser Lys Thr Thr Asn Val Arg Gln Thr Tyr Asp Asp
    50                  55                  60                  
Gly Ala Ala Thr Arg Leu Met Ser Thr Val Lys Pro Leu Arg Glu Pro
65                  70                  75                  80  
Ala Pro Ser Glu Asp Val Ile Asp Ile Lys Pro Glu Pro Asp Asp Leu
                85                  90                  95      
Ile Asp Glu Asp Leu Asn Phe Val Gln Glu Asn Pro Leu Ser Gln Lys
            100                 105                 110         
Lys Pro Thr Val Thr Leu Thr Tyr Gly Ser Ser Arg Pro Ser Ile Glu
        115                 120                 125             
Ile Tyr Arg Pro Pro Ala Ser Arg Asn Ala Asp Ser Gly Val His Leu
    130                 135                 140                 
Asn Arg Leu Gln Phe Gln Gln Gln Gln Asn Ser Ile His Ala Ala Lys
145                 150                 155                 160 
Gln Leu Asp Met Gln Ser Ser Trp Val Tyr Glu Thr Gly Arg Leu Cys
                165                 170                 175     
Glu Pro Glu Val Leu Asn Ser Leu Glu Glu Thr Tyr Ser Pro Phe Phe
            180                 185                 190         
Arg Asn Asn Ser Glu Lys Met Ser Met Glu Asp Glu Asn Phe Arg Lys
        195                 200                 205             
Arg Lys Leu Pro Val Val Ser Ser Val Val Lys Val Lys Lys Phe Asn
    210                 215                 220                 
His Asp Gly Glu Glu Glu Glu Glu Asp Asp Asp Tyr Gly Ser Arg Thr
225                 230                 235                 240 
Gly Ser Ile Ser Ser Ser Val Ser Val Pro Ala Lys Pro Glu Arg Arg
                245                 250                 255     
Pro Ser Leu Pro Pro Ser Lys Gln Ala Asn Lys Asn Leu Ile Leu Lys
            260                 265                 270         
Ala Ile Ser Glu Ala Gln Glu Ser Val Thr Lys Thr Thr Asn Tyr Ser
        275                 280                 285             
Thr Val Pro Gln Lys Gln Thr Leu Pro Val Ala Pro Arg Thr Arg Thr
    290                 295                 300                 
Ser Gln Glu Glu Leu Leu Ala Glu Val Val Gln Gly Gln Ser Arg Thr
305                 310                 315                 320 
Pro Arg Ile Ser Pro Pro Ile Lys Glu Glu Glu Thr Lys Gly Asp Ser
                325                 330                 335     
Val Glu Lys Asn Gln Gly Thr Gln Gln Arg Gln Leu Leu Ser Arg Leu
            340                 345                 350         
Gln Ile Asp Pro Val Met Ala Glu Thr Leu Gln Met Ser Gln Asp Tyr
        355                 360                 365             
Tyr Asp Met Glu Ser Met Val His Ala Asp Thr Arg Ser Phe Ile Leu
    370                 375                 380                 
Lys Lys Pro Lys Leu Ser Glu Glu Val Val Val Ala Pro Asn Gln Glu
385                 390                 395                 400 
Ser Gly Met Lys Thr Ala Asp Ser Leu Arg Val Leu Ser Gly His Leu
                405                 410                 415     
Met Gln Thr Arg Asp Leu Val Gln Pro Asp Lys Pro Ala Ser Pro Lys
            420                 425                 430         
Phe Ile Val Thr Leu Asp Gly Val Pro Ser Pro Pro Gly Tyr Met Ser
        435                 440                 445             
Asp Gln Glu Glu Asp Met Cys Phe Glu Gly Met Lys Pro Val Asn Gln
    450                 455                 460                 
Thr Ala Ala Ser Asn Lys Gly Leu Arg Gly Leu Leu His Pro Gln Gln
465                 470                 475                 480 
Leu His Leu Leu Ser Arg Gln Leu Glu Asp Pro Asn Gly Ser Phe Ser
                485                 490                 495     
Asn Ala Glu Met Ser Glu Leu Ser Val Ala Gln Lys Pro Glu Lys Leu
            500                 505                 510         
Leu Glu Arg Cys Lys Tyr Trp Pro Ala Cys Lys Asn Gly Asp Glu Cys
        515                 520                 525             
Ala Tyr His His Pro Ile Ser Pro Cys Lys Ala Phe Pro Asn Cys Lys
    530                 535                 540                 
Phe Ala Glu Lys Cys Leu Phe Val His Pro Asn Cys Lys Tyr Asp Ala
545                 550                 555                 560 
Lys Cys Thr Lys Pro Asp Cys Pro Phe Thr His Val Ser Arg Arg Ile
                565                 570                 575     
Pro Val Leu Ser Pro Lys Pro Val Ala Pro Pro Ala Pro Pro Ser Ser
            580                 585                 590         
Ser Gln Leu Cys Arg Tyr Phe Pro Ala Cys Lys Lys Met Glu Cys Pro
        595                 600                 605             
Phe Tyr His Pro Lys His Cys Arg Phe Asn Thr Gln Cys Thr Arg Pro
    610                 615                 620                 
Asp Cys Thr Phe Tyr His Pro Thr Ile Asn Val Pro Pro Arg His Ala
625                 630                 635                 640 
Leu Lys Trp Ile Arg Pro Gln Thr Ser Glu
                645                 650 


<210> 7298
<211> 344
<212> PRT
<213> Homo sapiens

<400> 7298
Lys Thr Thr Asn Tyr Ser Thr Val Pro Gln Lys Gln Thr Leu Pro Val
 1               5                  10                  15      
Ala Pro Arg Thr Arg Thr Ser Gln Glu Glu Leu Leu Ala Glu Val Val
            20                  25                  30          
Gln Gly Gln Ser Arg Thr Pro Arg Ile Ser Pro Pro Ile Lys Glu Glu
        35                  40                  45              
Glu Thr Lys Gly Asp Ser Val Glu Lys Asn Gln Asp Tyr Tyr Asp Met
    50                  55                  60                  
Glu Ser Met Val His Ala Asp Thr Arg Ser Phe Ile Leu Lys Lys Pro
65                  70                  75                  80  
Lys Leu Ser Glu Glu Val Val Val Ala Pro Asn Gln Glu Ser Gly Met
                85                  90                  95      
Lys Thr Ala Asp Ser Leu Arg Val Leu Ser Gly His Leu Met Gln Thr
            100                 105                 110         
Arg Asp Leu Val Gln Pro Asp Lys Pro Ala Ser Pro Lys Phe Ile Val
        115                 120                 125             
Thr Leu Asp Gly Val Pro Ser Pro Pro Gly Tyr Met Ser Asp Gln Glu
    130                 135                 140                 
Glu Asp Met Cys Phe Glu Gly Met Lys Pro Val Asn Gln Thr Ala Ala
145                 150                 155                 160 
Ser Asn Lys Gly Leu Arg Gly Leu Leu His Pro Gln Gln Leu His Leu
                165                 170                 175     
Leu Ser Arg Gln Leu Glu Asp Pro Asn Gly Ser Phe Ser Asn Ala Glu
            180                 185                 190         
Met Ser Glu Leu Ser Val Ala Gln Lys Pro Glu Lys Leu Leu Glu Arg
        195                 200                 205             
Cys Lys Tyr Trp Pro Ala Cys Lys Asn Gly Asp Glu Cys Ala Tyr His
    210                 215                 220                 
His Pro Ile Ser Pro Cys Lys Ala Phe Pro Asn Cys Lys Phe Ala Glu
225                 230                 235                 240 
Lys Cys Leu Phe Val His Pro Asn Cys Lys Tyr Asp Ala Lys Cys Thr
                245                 250                 255     
Lys Pro Asp Cys Pro Phe Thr His Val Ser Arg Arg Ile Pro Val Leu
            260                 265                 270         
Ser Pro Lys Pro Ala Val Ala Pro Pro Ala Pro Pro Ser Ser Ser Gln
        275                 280                 285             
Leu Cys Arg Tyr Phe Pro Ala Cys Lys Lys Met Glu Cys Pro Phe Tyr
    290                 295                 300                 
His Pro Lys His Cys Arg Phe Asn Thr Gln Cys Thr Arg Pro Asp Cys
305                 310                 315                 320 
Thr Phe Tyr His Pro Thr Ile Asn Val Pro Pro Arg His Ala Leu Lys
                325                 330                 335     
Trp Ile Arg Pro Gln Thr Ser Glu
            340                 


<210> 7299
<211> 587
<212> PRT
<213> Homo sapiens

<400> 7299
Met Asn Asp Ser Leu Phe Val Ser Leu Asp Arg Leu Leu Leu Glu Phe
 1               5                  10                  15      
Val Phe Gln Tyr Glu Gln Asp Ile Ser Thr Lys Glu Glu Met Ile Gln
            20                  25                  30          
Arg Ile Asn Lys Cys Cys Glu Asp Ile Lys Glu Asn Lys Val Thr Ile
        35                  40                  45              
Cys Arg Ile His Glu Thr Ile Asn Ala Thr Asp Glu Glu Ile Asp His
    50                  55                  60                  
Tyr Cys Lys His Ser Glu Glu Ile Lys Asp Asn Cys Arg Asn Trp Lys
65                  70                  75                  80  
Pro Thr Cys Asp Val Phe Arg Lys His Glu Asp Tyr Met Gln Asp Gln
                85                  90                  95      
Phe Thr Val Tyr Gln Gly Thr Val Glu Lys Asp Lys Glu Met Tyr His
            100                 105                 110         
Asp Tyr Ile Cys Gln Tyr Lys Glu Val Leu Lys Gln Tyr Gln Leu Lys
        115                 120                 125             
Tyr Ser Glu Thr Pro Phe Ser Arg Glu Tyr Tyr Glu Lys Lys Arg Glu
    130                 135                 140                 
His Glu Glu Ile Gln Ser Arg Val Leu Ala Cys Thr Glu Gln Leu Lys
145                 150                 155                 160 
Met Asn Glu Thr Ile Phe Met Lys Phe Arg Val Pro Ala Pro Phe Pro
                165                 170                 175     
Ser Leu Thr Lys Trp Thr Leu Asn Ile Val Asn Leu Arg Cys Glu Thr
            180                 185                 190         
Gln Asp Ile Leu Lys His Ala Ser Asn Leu Thr Lys Ser Ser Ser Glu
        195                 200                 205             
Leu Lys Lys Glu Val Asp Glu Met Glu Ile Glu Ile Asn Tyr Leu Asn
    210                 215                 220                 
Gln Gln Ile Ser Arg His Asn Glu Thr Lys Ala Leu Ser Glu Thr Leu
225                 230                 235                 240 
Glu Glu Lys Asn Lys Asn Thr Glu Asn Arg Lys Glu Leu Lys Glu Arg
                245                 250                 255     
Ile Phe Gly Lys Asp Glu His Val Leu Thr Leu Asn Lys Thr Gln Ser
            260                 265                 270         
Ser Gln Leu Phe Leu Pro Tyr Glu Ser Gln Lys Leu Val Arg Pro Ile
        275                 280                 285             
Lys Met His Ser Ser Glu Pro Arg Val Ala Asp Ile Lys Glu Glu Ser
    290                 295                 300                 
Ser Val Lys Gln Ser Lys Leu Ala Asn Ile Asp Phe Arg Gln Lys Glu
305                 310                 315                 320 
Asn Asp Thr Gln Ile Phe Asn Asp Ser Ala Val Asp Asn His Ser Lys
                325                 330                 335     
Cys Ser His Ile Thr Thr Ile Thr Ser Ser Gln Lys Phe Met Gln Val
            340                 345                 350         
Arg Leu Leu Thr Pro Gln Lys Gln Ser Asn Ser Asn Gln Trp Ser Glu
        355                 360                 365             
Lys Gly Asp Lys Asp Ala Glu Tyr Gly Asp Lys Gly Thr Val Arg Gln
    370                 375                 380                 
Val Arg Glu Ser Lys Cys Thr Ser Gln Ala Ile Tyr Thr Glu His Phe
385                 390                 395                 400 
Gly Lys Ser Ile Glu Asn Asp Ser Asp Glu Val Glu Glu Arg Ala Glu
                405                 410                 415     
Asn Phe Pro Arg Thr Ser Glu Ile Pro Ile Phe Leu Gly Thr Pro Lys
            420                 425                 430         
Ala Val Lys Ala Pro Glu Ser Leu Glu Lys Ile Lys Phe Pro Lys Thr
        435                 440                 445             
Pro Pro Phe Glu Ile Asn Arg Asn Arg Asn Ala Val Pro Glu Val Gln
    450                 455                 460                 
Thr Glu Lys Glu Ser Pro Gly Leu Ser Phe Leu Met Ser Tyr Thr Ser
465                 470                 475                 480 
Arg Ser Pro Gly Leu Asn Leu Phe Asp Ser Ser Val Phe Asp Thr Glu
                485                 490                 495     
Ile Ser Ser Asp Gln Phe Asn Glu His Tyr Ser Ala Arg Asn Leu Asn
            500                 505                 510         
Pro Leu Ser Ser Glu Gln Glu Ile Gly Asn Leu Phe Glu Lys Pro Glu
        515                 520                 525             
Gly Glu Asp Gly Phe Thr Phe Ser Phe Pro Ser Asp Thr Ser Thr His
    530                 535                 540                 
Thr Phe Gly Ala Gly Lys Asp Asp Phe Ser Phe Pro Phe Ser Phe Gly
545                 550                 555                 560 
Gln Gly Gln Asn Ser Ile Pro Ser Ser Ser Leu Lys Gly Phe Ser Ser
                565                 570                 575     
Ser Ser Gln Asn Thr Thr Gln Phe Thr Phe Phe
            580                 585         


<210> 7300
<211> 497
<212> PRT
<213> Homo sapiens

<400> 7300
Met Thr Asn Pro Pro Val Glu Val Arg Lys Asn Met Glu Val Phe Leu
 1               5                  10                  15      
Pro Gln Ser Tyr Cys Ala Phe Asp Phe Ala Thr Met Pro His Gln Leu
            20                  25                  30          
Gln Asp Thr Phe Leu Arg Ile Pro Leu Leu Val Glu Leu Trp His Lys
        35                  40                  45              
Asp Lys Met Ser Lys Asp Leu Leu Leu Gly Ile Ala Arg Ile Gln Leu
    50                  55                  60                  
Ser Asn Ile Leu Ser Ser Glu Lys Thr Arg Phe Leu Gly Ser Asn Gly
65                  70                  75                  80  
Glu Gln Cys Trp Arg Gln Thr Tyr Ser Glu Ser Val Pro Val Ile Ala
                85                  90                  95      
Ala Gln Gly Ser Asn Asn Arg Ile Ala Asp Leu Ser Tyr Thr Val Thr
            100                 105                 110         
Leu Glu Asp Tyr Gly Leu Val Lys Met Arg Glu Ile Phe Ile Ser Asp
        115                 120                 125             
Ser Ser Gln Gly Val Ser Ala Val Gln Gln Lys Pro Ser Ser Leu Pro
    130                 135                 140                 
Pro Ala Pro Cys Pro Ser Glu Ile Gln Thr Glu Pro Arg Glu Thr Leu
145                 150                 155                 160 
Glu Tyr Lys Ala Ala Leu Glu Leu Glu Met Trp Lys Glu Met Gln Glu
                165                 170                 175     
Asp Ile Phe Glu Asn Gln Leu Lys Gln Lys Glu Leu Ala His Met Gln
            180                 185                 190         
Ala Leu Ala Glu Glu Trp Lys Lys Arg Asp Arg Glu Arg Glu Ser Leu
        195                 200                 205             
Val Lys Lys Lys Val Ala Glu Tyr Thr Ile Leu Glu Gly Lys Leu Gln
    210                 215                 220                 
Lys Thr Leu Ile Asp Leu Glu Lys Arg Glu Gln Gln Leu Ala Ser Val
225                 230                 235                 240 
Glu Ser Glu Leu Gln Arg Glu Lys Lys Glu Leu Gln Ser Glu Arg Gln
                245                 250                 255     
Arg Asn Leu Gln Glu Leu Gln Asp Ser Ile Arg Arg Ala Lys Glu Asp
            260                 265                 270         
Cys Ile His Gln Val Glu Leu Glu Arg Leu Lys Ile Lys Gln Leu Glu
        275                 280                 285             
Glu Asp Lys His Arg Leu Gln Gln Gln Leu Asn Asp Ala Glu Asn Lys
    290                 295                 300                 
Tyr Lys Ile Leu Glu Lys Glu Phe Gln Gln Phe Lys Asp Gln Gln Asn
305                 310                 315                 320 
Asn Lys Pro Glu Ile Arg Leu Gln Ser Glu Ile Asn Leu Leu Thr Leu
                325                 330                 335     
Glu Lys Val Glu Leu Glu Arg Lys Leu Glu Ser Ala Thr Lys Ser Lys
            340                 345                 350         
Leu His Tyr Lys Gln Gln Trp Gly Arg Ala Leu Lys Glu Leu Ala Arg
        355                 360                 365             
Leu Lys Gln Arg Glu Gln Glu Ser Gln Met Ala Arg Leu Lys Lys Gln
    370                 375                 380                 
Gln Glu Glu Leu Glu Gln Met Arg Leu Arg Tyr Leu Ala Ala Glu Glu
385                 390                 395                 400 
Lys Asp Thr Val Lys Thr Glu Arg Gln Glu Leu Leu Asp Ile Arg Asn
                405                 410                 415     
Glu Leu Asn Arg Leu Arg Gln Gln Glu Gln Lys Gln Tyr Gln Asp Ser
            420                 425                 430         
Thr Glu Ile Ala Ser Gly Lys Lys Asp Gly Pro His Gly Ser Val Leu
        435                 440                 445             
Glu Glu Gly Leu Asp Asp Tyr Leu Thr Arg Leu Ile Glu Glu Arg Asp
    450                 455                 460                 
Thr Leu Met Arg Thr Gly Val Tyr Asn His Glu Asp Arg Ile Ile Ser
465                 470                 475                 480 
Glu Leu Asp Arg Gln Ile Arg Glu Ile Leu Ala Lys Ser Asn Ala Ser
                485                 490                 495     
Asn
    


<210> 7301
<211> 421
<212> PRT
<213> Homo sapiens

<400> 7301
Met Thr Ser Gln Glu Lys Thr Glu Glu Tyr Pro Phe Ala Asp Ile Phe
 1               5                  10                  15      
Asp Glu Asp Glu Thr Glu Arg Asn Phe Leu Leu Ser Lys Pro Val Cys
            20                  25                  30          
Phe Val Val Phe Gly Lys Pro Gly Val Gly Lys Thr Thr Leu Ala Arg
        35                  40                  45              
Tyr Ile Thr Gln Ala Trp Lys Cys Ile Arg Val Glu Ala Leu Pro Ile
    50                  55                  60                  
Leu Glu Glu Gln Ile Ala Ala Glu Thr Glu Ser Gly Val Met Leu Gln
65                  70                  75                  80  
Ser Met Leu Ile Ser Gly Gln Ser Ile Pro Asp Glu Leu Val Ile Lys
                85                  90                  95      
Leu Met Leu Glu Lys Leu Asn Ser Pro Glu Val Cys His Phe Gly Tyr
            100                 105                 110         
Ile Ile Thr Glu Ile Pro Ser Leu Ser Gln Asp Ala Met Thr Thr Leu
        115                 120                 125             
Gln Gln Ile Glu Leu Ile Lys Asn Leu Asn Leu Lys Pro Asp Val Ile
    130                 135                 140                 
Ile Asn Ile Lys Cys Pro Asp Tyr Asp Leu Cys Gln Arg Ile Ser Gly
145                 150                 155                 160 
Gln Arg Gln His Asn Asn Thr Gly Tyr Ile Tyr Ser Arg Asp Gln Trp
                165                 170                 175     
Asp Pro Glu Val Ile Glu Asn His Arg Lys Lys Lys Lys Glu Ala Gln
            180                 185                 190         
Lys Asp Gly Lys Gly Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu
        195                 200                 205             
Glu Glu Ala Phe Ile Ala Glu Met Gln Met Val Ala Glu Ile Leu His
    210                 215                 220                 
His Leu Val Gln Arg Pro Glu Asp Tyr Leu Glu Asn Val Glu Asn Ile
225                 230                 235                 240 
Val Lys Leu Tyr Lys Glu Thr Ile Leu Gln Thr Leu Glu Glu Val Met
                245                 250                 255     
Ala Glu His Asn Pro Gln Tyr Leu Ile Glu Leu Asn Gly Asn Lys Pro
            260                 265                 270         
Ala Glu Glu Leu Phe Met Ile Val Met Asp Arg Leu Lys Tyr Leu Asn
        275                 280                 285             
Leu Lys Arg Ala Ala Ile Leu Thr Lys Leu Gln Gly Ala Glu Glu Glu
    290                 295                 300                 
Ile Asn Asp Thr Met Glu Asn Asp Glu Leu Phe Arg Thr Leu Ala Ser
305                 310                 315                 320 
Tyr Lys Leu Ile Ala Pro Arg Tyr Arg Trp Gln Arg Ser Lys Trp Gly
                325                 330                 335     
Arg Thr Cys Pro Val Asn Leu Lys Asp Gly Asn Ile Tyr Ser Gly Leu
            340                 345                 350         
Pro Asp Tyr Ser Val Ser Phe Leu Gly Lys Ile Tyr Cys Leu Ser Ser
        355                 360                 365             
Glu Glu Ala Leu Lys Pro Phe Leu Leu Asn Pro Arg Pro Tyr Leu Leu
    370                 375                 380                 
Pro Pro Met Pro Gly Pro Pro Cys Lys Val Phe Ile Leu Gly Pro Gln
385                 390                 395                 400 
Tyr Ser Gly Lys Thr Thr Leu Cys Asn Met Leu Ala Glu Asn Tyr Lys
                405                 410                 415     
Gly Lys Val Thr Asn
            420     


<210> 7302
<211> 279
<212> PRT
<213> Homo sapiens

<400> 7302
Met Leu Leu Ala Ala Ser Lys Val Leu Asp Arg Leu Lys Pro Val Ile
 1               5                  10                  15      
Gly Val Asn Thr Asp Pro Glu Arg Ser Glu Gly His Leu Cys Leu Pro
            20                  25                  30          
Val Arg Tyr Thr His Ser Phe Pro Glu Ala Leu Gln Lys Phe Tyr Arg
        35                  40                  45              
Gly Glu Phe Arg Trp Leu Trp Arg Gln Arg Ile Arg Leu Tyr Leu Glu
    50                  55                  60                  
Gly Thr Gly Ile Asn Pro Val Pro Val Asp Leu His Glu Gln Gln Leu
65                  70                  75                  80  
Ser Leu Asn Gln His Asn Arg Ala Leu Asn Ile Glu Arg Ala His Asp
                85                  90                  95      
Glu Arg Ser Glu Ala Ser Gly Pro Gln Leu Leu Pro Val Arg Ala Leu
            100                 105                 110         
Asn Glu Val Phe Ile Gly Glu Ser Leu Ser Ser Arg Ala Ser Tyr Tyr
        115                 120                 125             
Glu Ile Ser Val Asp Asp Gly Pro Trp Glu Lys Gln Lys Ser Ser Gly
    130                 135                 140                 
Leu Asn Leu Cys Thr Gly Thr Gly Ser Lys Ala Trp Ser Phe Asn Ile
145                 150                 155                 160 
Asn Arg Val Ala Thr Gln Ala Val Glu Asp Val Leu Asn Ile Ala Lys
                165                 170                 175     
Arg Gln Gly Asn Leu Ser Leu Pro Leu Asn Arg Glu Leu Val Glu Lys
            180                 185                 190         
Val Thr Asn Glu Tyr Asn Glu Ser Leu Leu Tyr Ser Pro Glu Glu Pro
        195                 200                 205             
Lys Ile Leu Phe Ser Ile Arg Glu Pro Ile Ala Asn Arg Val Phe Ser
    210                 215                 220                 
Ser Ser Arg Gln Arg Cys Phe Ser Ser Lys Val Cys Val Arg Ser Arg
225                 230                 235                 240 
Cys Trp Asp Ala Cys Met Val Val Asp Gly Gly Thr Ser Phe Glu Phe
                245                 250                 255     
Asn Asp Gly Ala Ile Ala Ser Met Met Ile Asn Lys Glu Asp Glu Leu
            260                 265                 270         
Arg Thr Val Leu Leu Glu Gln
        275                 


<210> 7303
<211> 873
<212> PRT
<213> Homo sapiens

<400> 7303
Pro Leu Gly Ser Leu Cys Ser Ala Pro Arg Pro Gly Arg Ala Pro Thr
 1               5                  10                  15      
Gly Ala Ala Arg Gly Trp Pro Ala Ser Ser Leu Leu Arg Arg Pro Ser
            20                  25                  30          
Leu Leu Pro Arg Gly Pro Pro Gly Arg Gly Ser Ala Ala Leu Arg Pro
        35                  40                  45              
Leu Asn Ala Arg Pro Pro Arg Leu Leu Arg Gly Ala Ala Trp Pro Gly
    50                  55                  60                  
Pro Gly Pro Gly Trp Pro Gln Cys Pro Ala Ala Pro Leu Arg Ser Ala
65                  70                  75                  80  
Gln Arg Val Pro Phe Ala Pro Ala Leu Arg Pro Ser Leu Ser Ala Gly
                85                  90                  95      
Gly Met Ala Leu Ser Ser Glu Pro Ala Glu Met Pro Arg Gln Phe Pro
            100                 105                 110         
Lys Leu Asn Ile Ser Glu Val Asp Glu Gln Val Arg Leu Leu Ala Glu
        115                 120                 125             
Lys Val Phe Ala Lys Val Leu Arg Glu Glu Asp Ser Lys Asp Ala Leu
    130                 135                 140                 
Ser Leu Phe Thr Val Pro Glu Asp Cys Pro Ile Gly Gln Lys Glu Ala
145                 150                 155                 160 
Lys Glu Arg Glu Leu Gln Lys Glu Leu Ala Glu Gln Lys Ser Val Glu
                165                 170                 175     
Thr Ala Lys Arg Lys Lys Ser Phe Lys Met Ile Arg Ser Gln Ser Leu
            180                 185                 190         
Ser Leu Gln Met Pro Pro Gln Gln Asp Trp Lys Gly Pro Pro Ala Ala
        195                 200                 205             
Ser Pro Ala Met Ser Pro Thr Thr Pro Val Val Thr Gly Ala Thr Ser
    210                 215                 220                 
Leu Pro Thr Pro Ala Pro Tyr Ala Met Pro Glu Phe Gln Arg Val Thr
225                 230                 235                 240 
Ile Ser Gly Asp Tyr Cys Ala Gly Ile Thr Leu Glu Asp Tyr Glu Gln
                245                 250                 255     
Ala Ala Lys Ser Leu Ala Lys Ala Leu Met Ile Arg Glu Lys Tyr Ala
            260                 265                 270         
Arg Leu Ala Tyr His Arg Phe Pro Arg Ile Thr Ser Gln Tyr Leu Gly
        275                 280                 285             
His Pro Arg Ala Asp Thr Ala Pro Pro Glu Glu Gly Leu Pro Asp Phe
    290                 295                 300                 
His Pro Pro Pro Leu Pro Gln Glu Asp Pro Tyr Cys Leu Asp Asp Ala
305                 310                 315                 320 
Pro Pro Asn Leu Asp Tyr Leu Val His Met Gln Gly Gly Ile Leu Phe
                325                 330                 335     
Val Tyr Asp Asn Lys Lys Met Leu Glu His Gln Glu Pro His Ser Leu
            340                 345                 350         
Pro Tyr Pro Asp Leu Glu Thr Tyr Thr Val Asp Met Ser His Ile Leu
        355                 360                 365             
Ala Leu Ile Thr Asp Gly Pro Thr Lys Thr Tyr Cys His Arg Arg Leu
    370                 375                 380                 
Asn Phe Leu Glu Ser Lys Phe Ser Leu His Glu Met Leu Asn Glu Met
385                 390                 395                 400 
Ser Glu Phe Lys Glu Leu Lys Ser Asn Pro His Arg Asp Phe Tyr Asn
                405                 410                 415     
Val Arg Lys Val Asp Thr His Ile His Ala Ala Ala Cys Met Asn Gln
            420                 425                 430         
Lys His Leu Leu Arg Phe Ile Lys His Thr Tyr Gln Thr Glu Pro Asp
        435                 440                 445             
Arg Thr Val Ala Glu Lys Arg Gly Arg Lys Ile Thr Leu Arg Gln Val
    450                 455                 460                 
Phe Asp Gly Leu His Met Asp Pro Tyr Asp Leu Thr Val Asp Ser Leu
465                 470                 475                 480 
Asp Val His Ala Gly Arg Gln Thr Phe His Arg Phe Asp Lys Phe Asn
                485                 490                 495     
Ser Lys Tyr Asn Pro Val Gly Ala Ser Glu Leu Arg Asp Leu Tyr Leu
            500                 505                 510         
Lys Thr Glu Asn Tyr Leu Gly Gly Glu Tyr Phe Ala Arg Met Val Lys
        515                 520                 525             
Glu Val Ala Arg Glu Leu Glu Glu Ser Lys Tyr Gln Tyr Ser Glu Pro
    530                 535                 540                 
Arg Leu Ser Ile Tyr Gly Arg Ser Pro Glu Glu Trp Pro Asn Leu Ala
545                 550                 555                 560 
Tyr Trp Phe Ile Gln His Lys Val Tyr Ser Pro Asn Met Arg Trp Ile
                565                 570                 575     
Ile Gln Val Pro Arg Ile Tyr Asp Ile Phe Arg Ser Lys Lys Leu Leu
            580                 585                 590         
Pro Asn Phe Gly Lys Met Leu Glu Asn Ile Phe Leu Pro Leu Phe Lys
        595                 600                 605             
Ala Thr Ile Asn Pro Gln Asp His Arg Glu Leu His Leu Phe Leu Lys
    610                 615                 620                 
Tyr Val Thr Gly Phe Asp Ser Val Asp Asp Glu Ser Lys His Ser Asp
625                 630                 635                 640 
His Met Phe Ser Asp Lys Ser Pro Asn Pro Asp Val Trp Thr Ser Glu
                645                 650                 655     
Gln Asn Pro Pro Tyr Ser Tyr Tyr Leu Tyr Tyr Met Tyr Ala Asn Ile
            660                 665                 670         
Met Val Leu Asn Asn Leu Arg Arg Glu Arg Gly Leu Ser Thr Phe Leu
        675                 680                 685             
Phe Arg Pro His Cys Gly Glu Ala Gly Ser Ile Thr His Leu Val Ser
    690                 695                 700                 
Ala Phe Leu Thr Ala Asp Asn Ile Ser His Gly Leu Leu Leu Lys Lys
705                 710                 715                 720 
Ser Pro Val Leu Gln Tyr Leu Tyr Tyr Leu Ala Gln Ile Pro Ile Ala
                725                 730                 735     
Met Ser Pro Leu Ser Asn Asn Ser Leu Phe Leu Glu Tyr Ser Lys Asn
            740                 745                 750         
Pro Leu Arg Glu Phe Leu His Lys Gly Leu His Val Ser Leu Ser Thr
        755                 760                 765             
Asp Asp Pro Met Gln Phe His Tyr Thr Lys Glu Ala Leu Met Glu Glu
    770                 775                 780                 
Tyr Ala Ile Ala Ala Gln Val Trp Lys Leu Ser Thr Cys Asp Leu Cys
785                 790                 795                 800 
Glu Ile Ala Arg Asn Ser Val Leu Gln Ser Gly Leu Ser His Gln Glu
                805                 810                 815     
Lys Gln Lys Phe Leu Gly Gln Asn Tyr Tyr Lys Glu Gly Pro Glu Gly
            820                 825                 830         
Asn Asp Ile Arg Lys Thr Asn Val Ala Gln Ile Arg Met Ala Phe Arg
        835                 840                 845             
Tyr Glu Thr Leu Cys Asn Glu Leu Ser Phe Leu Ser Asp Ala Met Lys
    850                 855                 860                 
Ser Glu Glu Ile Thr Ala Leu Thr Asn
865                 870             


<210> 7304
<211> 767
<212> PRT
<213> Homo sapiens

<400> 7304
Met Pro Arg Gln Phe Pro Lys Leu Asn Ile Ser Glu Val Asp Glu Gln
 1               5                  10                  15      
Val Arg Leu Leu Ala Glu Lys Val Phe Ala Lys Val Leu Arg Glu Glu
            20                  25                  30          
Asp Ser Lys Asp Ala Leu Ser Leu Phe Thr Val Pro Glu Asp Cys Pro
        35                  40                  45              
Ile Gly Gln Lys Glu Ala Lys Glu Arg Glu Leu Gln Lys Glu Leu Ala
    50                  55                  60                  
Glu Gln Lys Ser Val Glu Thr Ala Lys Arg Lys Lys Ser Phe Lys Met
65                  70                  75                  80  
Ile Arg Ser Gln Ser Leu Ser Leu Gln Met Pro Pro Gln Gln Asp Trp
                85                  90                  95      
Lys Gly Pro Pro Ala Ala Ser Pro Ala Met Ser Pro Thr Thr Pro Val
            100                 105                 110         
Val Thr Gly Ala Thr Ser Leu Pro Thr Pro Ala Pro Tyr Ala Met Pro
        115                 120                 125             
Glu Phe Gln Arg Val Thr Ile Ser Gly Asp Tyr Cys Ala Gly Ile Thr
    130                 135                 140                 
Leu Glu Asp Tyr Glu Gln Ala Ala Lys Ser Leu Ala Lys Ala Leu Met
145                 150                 155                 160 
Ile Arg Glu Lys Tyr Ala Arg Leu Ala Tyr His Arg Phe Pro Arg Ile
                165                 170                 175     
Thr Ser Gln Tyr Leu Gly His Pro Arg Ala Asp Thr Ala Pro Pro Glu
            180                 185                 190         
Glu Gly Leu Pro Asp Phe His Pro Pro Pro Leu Pro Gln Glu Asp Pro
        195                 200                 205             
Tyr Cys Leu Asp Asp Ala Pro Pro Asn Leu Asp Tyr Leu Val His Met
    210                 215                 220                 
Gln Gly Gly Ile Leu Phe Val Tyr Asp Asn Lys Lys Met Leu Glu His
225                 230                 235                 240 
Gln Glu Pro His Ser Leu Pro Tyr Pro Asp Leu Glu Thr Tyr Thr Val
                245                 250                 255     
Asp Met Ser His Ile Leu Ala Leu Ile Thr Asp Gly Pro Thr Lys Thr
            260                 265                 270         
Tyr Cys His Arg Arg Leu Asn Phe Leu Glu Ser Lys Phe Ser Leu His
        275                 280                 285             
Glu Met Leu Asn Glu Met Ser Glu Phe Lys Glu Leu Lys Ser Asn Pro
    290                 295                 300                 
His Arg Asp Phe Tyr Asn Val Arg Lys Val Asp Thr His Ile His Ala
305                 310                 315                 320 
Ala Ala Cys Met Asn Gln Lys His Leu Leu Arg Phe Ile Lys His Thr
                325                 330                 335     
Tyr Gln Thr Glu Pro Asp Arg Thr Val Ala Glu Lys Arg Gly Arg Lys
            340                 345                 350         
Ile Thr Leu Arg Gln Val Phe Asp Gly Leu His Met Asp Pro Tyr Asp
        355                 360                 365             
Leu Thr Val Asp Ser Leu Asp Val His Ala Gly Arg Gln Thr Phe His
    370                 375                 380                 
Arg Phe Asp Lys Phe Asn Ser Lys Tyr Asn Pro Val Gly Ala Ser Glu
385                 390                 395                 400 
Leu Arg Asp Leu Tyr Leu Lys Thr Glu Asn Tyr Leu Gly Gly Glu Tyr
                405                 410                 415     
Phe Ala Arg Met Val Lys Glu Val Ala Arg Glu Leu Glu Glu Ser Lys
            420                 425                 430         
Tyr Gln Tyr Ser Glu Pro Arg Leu Ser Ile Tyr Gly Arg Ser Pro Glu
        435                 440                 445             
Glu Trp Pro Asn Leu Ala Tyr Trp Phe Ile Gln His Lys Val Tyr Ser
    450                 455                 460                 
Pro Asn Met Arg Trp Ile Ile Gln Val Pro Arg Ile Tyr Asp Ile Phe
465                 470                 475                 480 
Arg Ser Lys Lys Leu Leu Pro Asn Phe Gly Lys Met Leu Glu Asn Ile
                485                 490                 495     
Phe Leu Pro Leu Phe Lys Ala Thr Ile Asn Pro Gln Asp His Arg Glu
            500                 505                 510         
Leu His Leu Phe Leu Lys Tyr Val Thr Gly Phe Asp Ser Val Asp Asp
        515                 520                 525             
Glu Ser Lys His Ser Asp His Met Phe Ser Asp Lys Ser Pro Asn Pro
    530                 535                 540                 
Asp Val Trp Thr Ser Glu Gln Asn Pro Pro Tyr Ser Tyr Tyr Leu Tyr
545                 550                 555                 560 
Tyr Met Tyr Ala Asn Ile Met Val Leu Asn Asn Leu Arg Arg Glu Arg
                565                 570                 575     
Gly Leu Ser Thr Phe Leu Phe Arg Pro His Cys Gly Glu Ala Gly Ser
            580                 585                 590         
Ile Thr His Leu Val Ser Ala Phe Leu Thr Ala Asp Asn Ile Ser His
        595                 600                 605             
Gly Leu Leu Leu Lys Lys Ser Pro Val Leu Gln Tyr Leu Tyr Tyr Leu
    610                 615                 620                 
Ala Gln Ile Pro Ile Ala Met Ser Pro Leu Ser Asn Asn Ser Leu Phe
625                 630                 635                 640 
Leu Glu Tyr Ser Lys Asn Pro Leu Arg Glu Phe Leu His Lys Gly Leu
                645                 650                 655     
His Val Ser Leu Ser Thr Asp Asp Pro Met Gln Phe His Tyr Thr Lys
            660                 665                 670         
Glu Ala Leu Met Glu Glu Tyr Ala Ile Ala Ala Gln Val Trp Lys Leu
        675                 680                 685             
Ser Thr Cys Asp Leu Cys Glu Ile Ala Arg Asn Ser Val Leu Gln Ser
    690                 695                 700                 
Gly Leu Ser His Gln Glu Lys Gln Lys Phe Leu Gly Gln Asn Tyr Tyr
705                 710                 715                 720 
Lys Glu Gly Pro Glu Gly Asn Asp Ile Arg Lys Thr Asn Val Ala Gln
                725                 730                 735     
Ile Arg Met Ala Phe Arg Tyr Glu Thr Leu Cys Asn Glu Leu Ser Phe
            740                 745                 750         
Leu Ser Asp Ala Met Lys Ser Glu Glu Ile Thr Ala Leu Thr Asn
        755                 760                 765         


<210> 7305
<211> 399
<212> PRT
<213> Homo sapiens

<400> 7305
Met Val Ser Lys Leu Thr Ser Leu Gln Gln Glu Leu Leu Ser Ala Leu
 1               5                  10                  15      
Leu Ser Ser Gly Val Thr Lys Glu Val Leu Val Gln Ala Leu Glu Glu
            20                  25                  30          
Leu Leu Pro Ser Pro Asn Phe Gly Val Lys Leu Glu Thr Leu Pro Leu
        35                  40                  45              
Ser Pro Gly Ser Gly Ala Glu Pro Asp Thr Lys Pro Val Phe His Thr
    50                  55                  60                  
Leu Thr Asn Gly His Ala Lys Gly Arg Leu Ser Gly Asp Glu Gly Ser
65                  70                  75                  80  
Glu Asp Gly Asp Asp Tyr Asp Thr Pro Pro Ile Leu Lys Glu Leu Gln
                85                  90                  95      
Ala Leu Asn Thr Glu Glu Ala Ala Glu Gln Arg Ala Glu Val Asp Arg
            100                 105                 110         
Met Leu Ser Glu Asp Pro Trp Arg Ala Ala Lys Met Ile Lys Gly Tyr
        115                 120                 125             
Met Gln Gln His Asn Ile Pro Gln Arg Glu Val Val Asp Val Thr Gly
    130                 135                 140                 
Leu Asn Gln Ser His Leu Ser Gln His Leu Asn Lys Gly Thr Pro Met
145                 150                 155                 160 
Lys Thr Gln Lys Arg Ala Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln
                165                 170                 175     
Arg Glu Ile Leu Arg Gln Phe Asn Gln Thr Val Gln Ser Ser Gly Asn
            180                 185                 190         
Met Thr Asp Lys Ser Ser Gln Asp Gln Leu Leu Phe Leu Phe Pro Glu
        195                 200                 205             
Phe Ser Gln Gln Ser His Gly Pro Gly Gln Ser Asp Asp Ala Cys Ser
    210                 215                 220                 
Glu Pro Thr Asn Lys Lys Met Arg Arg Asn Arg Phe Lys Trp Gly Pro
225                 230                 235                 240 
Ala Ser Gln Gln Ile Leu Tyr Gln Ala Tyr Asp Arg Gln Lys Asn Pro
                245                 250                 255     
Ser Lys Glu Glu Arg Glu Ala Leu Val Glu Glu Cys Asn Arg Ala Glu
            260                 265                 270         
Cys Leu Gln Arg Gly Val Ser Pro Ser Lys Ala His Gly Leu Gly Ser
        275                 280                 285             
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
    290                 295                 300                 
Lys Glu Glu Ala Phe Arg Gln Lys Leu Ala Met Asp Ala Tyr Ser Ser
305                 310                 315                 320 
Asn Gln Thr His Ser Leu Asn Pro Leu Leu Ser His Gly Ser Pro His
                325                 330                 335     
His Gln Pro Ser Ser Ser Pro Pro Asn Lys Leu Ser Gly Lys Gln Arg
            340                 345                 350         
Leu Gly Leu Thr Ala Ser Ala Thr Gln Pro Ser Trp Phe Leu Pro Arg
        355                 360                 365             
Ile Leu Ser Gly Leu Arg Val Phe Arg Gly Ala Asn Ala Phe Glu Met
    370                 375                 380                 
Ile Leu Gly Pro Leu Ser His Cys Gln Asn Ile Leu Pro Trp Lys
385                 390                 395                 


<210> 7306
<211> 557
<212> PRT
<213> Homo sapiens

<400> 7306
Met Val Ser Lys Leu Thr Ser Leu Gln Gln Glu Leu Leu Ser Ala Leu
 1               5                  10                  15      
Leu Ser Ser Gly Val Thr Lys Glu Val Leu Val Gln Ala Leu Glu Glu
            20                  25                  30          
Leu Leu Pro Ser Pro Asn Phe Gly Val Lys Leu Glu Thr Leu Pro Leu
        35                  40                  45              
Ser Pro Gly Ser Gly Ala Glu Pro Asp Thr Lys Pro Val Phe His Thr
    50                  55                  60                  
Leu Thr Asn Gly His Ala Lys Gly Arg Leu Ser Gly Asp Glu Gly Ser
65                  70                  75                  80  
Glu Asp Gly Asp Asp Tyr Asp Thr Pro Pro Ile Leu Lys Glu Leu Gln
                85                  90                  95      
Ala Leu Asn Thr Glu Glu Ala Ala Glu Gln Arg Ala Glu Val Asp Arg
            100                 105                 110         
Met Leu Ser Glu Asp Pro Trp Arg Ala Ala Lys Met Ile Lys Gly Tyr
        115                 120                 125             
Met Gln Gln His Asn Ile Pro Gln Arg Glu Val Val Asp Val Thr Gly
    130                 135                 140                 
Leu Asn Gln Ser His Leu Ser Gln His Leu Asn Lys Gly Thr Pro Met
145                 150                 155                 160 
Lys Thr Gln Lys Arg Ala Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln
                165                 170                 175     
Arg Glu Ile Leu Arg Gln Phe Asn Gln Thr Val Gln Ser Ser Gly Asn
            180                 185                 190         
Met Thr Asp Lys Ser Ser Gln Asp Gln Leu Leu Phe Leu Phe Pro Glu
        195                 200                 205             
Phe Ser Gln Gln Ser His Gly Pro Gly Gln Ser Asp Asp Ala Cys Ser
    210                 215                 220                 
Glu Pro Thr Asn Lys Lys Met Arg Arg Asn Arg Phe Lys Trp Gly Pro
225                 230                 235                 240 
Ala Ser Gln Gln Ile Leu Tyr Gln Ala Tyr Asp Arg Gln Lys Asn Pro
                245                 250                 255     
Ser Lys Glu Glu Arg Glu Ala Leu Val Glu Glu Cys Asn Arg Ala Glu
            260                 265                 270         
Cys Leu Gln Arg Gly Val Ser Pro Ser Lys Ala His Gly Leu Gly Ser
        275                 280                 285             
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
    290                 295                 300                 
Lys Glu Glu Ala Phe Arg Gln Lys Leu Ala Met Asp Ala Tyr Ser Ser
305                 310                 315                 320 
Asn Gln Thr His Ser Leu Asn Pro Leu Leu Ser His Gly Ser Pro His
                325                 330                 335     
His Gln Pro Ser Ser Ser Pro Pro Asn Lys Leu Ser Gly Val Arg Tyr
            340                 345                 350         
Ser Gln Gln Gly Asn Asn Glu Ile Thr Ser Ser Ser Thr Ile Ser His
        355                 360                 365             
His Gly Asn Ser Ala Met Val Thr Ser Gln Ser Val Leu Gln Gln Val
    370                 375                 380                 
Ser Pro Ala Ser Leu Asp Pro Gly His Asn Leu Leu Ser Pro Asp Gly
385                 390                 395                 400 
Lys Met Ile Ser Val Ser Gly Gly Gly Leu Pro Pro Val Ser Thr Leu
                405                 410                 415     
Thr Asn Ile His Ser Leu Ser His His Asn Pro Gln Gln Ser Gln Asn
            420                 425                 430         
Leu Ile Met Thr Pro Leu Ser Gly Val Met Ala Ile Ala Gln Ser Leu
        435                 440                 445             
Asn Thr Ser Gln Ala Gln Ser Val Pro Val Ile Asn Ser Val Ala Gly
    450                 455                 460                 
Ser Leu Ala Ala Leu Gln Pro Val Gln Phe Ser Gln Gln Leu His Ser
465                 470                 475                 480 
Pro His Gln Gln Pro Leu Met Gln Gln Ser Pro Gly Ser His Met Ala
                485                 490                 495     
Gln Gln Pro Phe Met Ala Ala Val Thr Gln Leu Gln Asn Ser His Met
            500                 505                 510         
Tyr Ala His Lys Gln Glu Pro Pro Gln Tyr Ser His Thr Ser Arg Phe
        515                 520                 525             
Pro Ser Ala Met Val Val Thr Asp Thr Ser Ser Ile Ser Thr Leu Thr
    530                 535                 540                 
Asn Met Ser Ser Ser Lys Gln Cys Pro Leu Gln Ala Trp
545                 550                 555         


<210> 7307
<211> 441
<212> PRT
<213> Homo sapiens

<400> 7307
Met Leu Gln Cys Pro Ser Val Glu Val Ser Phe Leu Pro Leu Ile Val
 1               5                  10                  15      
Asn Thr Val Ala Leu Pro Asp Glu Leu Ser Tyr Ile Cys Thr His Gly
            20                  25                  30          
Glu Asp Trp Asp Val Ala Tyr Ile Ile His Leu Tyr Pro Ser Leu Thr
        35                  40                  45              
Leu Arg Asn Leu Leu Pro Tyr Ser Leu Arg Tyr Leu Leu Glu Gly Thr
    50                  55                  60                  
Ala Glu Thr His Glu Leu Ala Glu Gly Ser Thr Ala Asp Val Leu His
65                  70                  75                  80  
Ser Arg Ile Ser Gly Glu Ile Met Glu Leu Val Leu Val Lys Tyr Gln
                85                  90                  95      
Gly Lys Asn Trp Asn Gly His Phe Arg Ile Arg Asp Thr Leu Pro Glu
            100                 105                 110         
Phe Phe Pro Val Cys Phe Ser Ser Asp Ser Thr Glu Val Thr Thr Val
        115                 120                 125             
Asp Leu Ser Val His Val Arg Arg Ile Gly Ser Arg Met Val Leu Ser
    130                 135                 140                 
Val Phe Ser Pro Tyr Trp Leu Ile Asn Lys Thr Thr Arg Val Leu Gln
145                 150                 155                 160 
Tyr Arg Ser Glu Asp Ile His Val Lys His Pro Ala Asp Phe Arg Asp
                165                 170                 175     
Ile Ile Leu Phe Ser Phe Lys Lys Lys Asn Ile Phe Thr Lys Asn Lys
            180                 185                 190         
Val Gln Leu Lys Ile Ser Thr Ser Ala Trp Ser Ser Ser Phe Ser Leu
        195                 200                 205             
Asp Thr Val Gly Ser Tyr Gly Cys Val Lys Cys Pro Ala Asn Asn Met
    210                 215                 220                 
Glu Tyr Leu Val Gly Val Ser Ile Lys Met Ser Ser Phe Asn Leu Ser
225                 230                 235                 240 
Arg Ile Val Thr Leu Thr Pro Phe Cys Thr Ile Ala Asn Lys Ser Ser
                245                 250                 255     
Leu Glu Leu Glu Val Gly Glu Ile Ala Ser Asp Gly Ser Met Pro Thr
            260                 265                 270         
Asn Lys Trp Asn Tyr Ile Ala Ser Ser Glu Cys Leu Pro Phe Trp Pro
        275                 280                 285             
Glu Asn Leu Ser Gly Lys Leu Cys Val Arg Val Val Gly Cys Glu Gly
    290                 295                 300                 
Ser Ser Lys Pro Phe Phe Tyr Asn Arg Gln Asp Asn Gly Thr Leu Leu
305                 310                 315                 320 
Ser Leu Glu Asp Leu Asn Gly Gly Ile Leu Val Asp Val Asn Thr Ala
                325                 330                 335     
Glu His Ser Thr Val Ile Thr Phe Ser Asp Tyr His Glu Gly Ser Ala
            340                 345                 350         
Pro Ala Leu Ile Met Asn His Thr Pro Trp Asp Ile Leu Thr Tyr Lys
        355                 360                 365             
Gln Ser Gly Ser Pro Glu Glu Met Val Leu Leu Pro Arg Gln Ala Arg
    370                 375                 380                 
Leu Phe Ala Trp Ala Asp Pro Thr Gly Thr Arg Lys Leu Thr Trp Thr
385                 390                 395                 400 
Tyr Ala Ala Asn Val Gly Glu His Asp Leu Leu Lys Val Ser Phe Asp
                405                 410                 415     
Val Asn Glu Cys Tyr Met Ser Tyr Leu Thr Val Lys Glu Val Glu Lys
            420                 425                 430         
Leu Ser Ser Leu Thr Pro Cys Pro Asn
        435                 440     


<210> 7308
<211> 1916
<212> PRT
<213> Homo sapiens

<400> 7308
Met Leu Leu Ser Ile Gln Arg Asn Leu Ala Ala Ala Trp Tyr Val Gln
 1               5                  10                  15      
Ile Pro Gly Met Glu Ile Lys Gly Lys Leu Lys Pro Met Gln Val Ala
            20                  25                  30          
Leu Ser Glu Asp Asp Leu Thr Val Leu Met Lys Ile Leu Leu Glu Asn
        35                  40                  45              
Leu Gly Glu Ala Ser Ser Gln Pro Ser Pro Thr Gln Ser Val Gln Glu
    50                  55                  60                  
Thr Val Arg Val Arg Lys Val Asp Val Ser Ser Val Pro Asp His Leu
65                  70                  75                  80  
Lys Glu Gln Glu Asp Trp Thr Asp Ser Lys Leu Ser Met Asn Gln Ile
                85                  90                  95      
Val Ser Leu Gln Phe Asp Phe His Phe Glu Ser Leu Ser Ile Ile Leu
            100                 105                 110         
Tyr Asn Asn Asp Ile Asn Gln Glu Ser Gly Val Ala Phe His Asn Asp
        115                 120                 125             
Ser Phe Gln Leu Gly Glu Leu Arg Leu His Leu Met Ala Ser Ser Gly
    130                 135                 140                 
Lys Met Phe Lys Asp Gly Ser Met Asn Val Ser Val Lys Leu Lys Thr
145                 150                 155                 160 
Cys Thr Leu Asp Asp Leu Arg Glu Gly Ile Glu Arg Ala Thr Ser Arg
                165                 170                 175     
Met Ile Asp Arg Lys Asn Asp Gln Asp Asn Asn Ser Ser Met Ile Asp
            180                 185                 190         
Ile Ser Tyr Lys Gln Asp Lys Asn Gly Ser Gln Ile Asp Ala Val Leu
        195                 200                 205             
Asp Lys Leu Tyr Val Cys Ala Ser Val Glu Phe Leu Met Thr Val Ala
    210                 215                 220                 
Asp Phe Phe Ile Lys Ala Val Pro Gln Ser Pro Glu Asn Val Ala Lys
225                 230                 235                 240 
Glu Thr Gln Ile Leu Pro Arg Gln Thr Ala Thr Gly Lys Val Lys Ile
                245                 250                 255     
Glu Lys Asp Asp Ser Val Arg Pro Asn Met Thr Leu Lys Ala Met Ile
            260                 265                 270         
Thr Asp Pro Glu Val Val Phe Val Ala Ser Leu Thr Lys Ala Asp Ala
        275                 280                 285             
Pro Ala Leu Thr Ala Ser Phe Gln Cys Asn Leu Ser Leu Ser Thr Ser
    290                 295                 300                 
Lys Leu Glu Gln Met Met Glu Ala Ser Val Arg Asp Leu Lys Val Leu
305                 310                 315                 320 
Ala Cys Pro Phe Leu Arg Glu Lys Arg Gly Lys Asn Ile Thr Thr Val
                325                 330                 335     
Leu Gln Pro Cys Ser Leu Phe Met Glu Lys Cys Thr Trp Ala Ser Gly
            340                 345                 350         
Lys Gln Asn Ile Asn Ile Met Val Lys Glu Phe Ile Ile Lys Ile Ser
        355                 360                 365             
Pro Ile Ile Leu Asn Thr Val Leu Thr Ile Met Ala Ala Leu Ser Pro
    370                 375                 380                 
Lys Thr Lys Glu Asp Gly Ser Lys Asp Thr Ser Lys Glu Met Glu Asn
385                 390                 395                 400 
Leu Trp Gly Ile Lys Ser Ile Asn Asp Tyr Asn Thr Trp Phe Leu Gly
                405                 410                 415     
Val Asp Thr Ala Thr Glu Ile Thr Glu Ser Phe Lys Gly Ile Glu His
            420                 425                 430         
Ser Leu Ile Glu Glu Asn Cys Gly Val Val Val Glu Ser Ile Gln Val
        435                 440                 445             
Thr Leu Glu Cys Gly Leu Gly His Arg Thr Val Pro Leu Leu Leu Ala
    450                 455                 460                 
Glu Ser Lys Phe Ser Gly Asn Ile Lys Asn Trp Thr Ser Leu Met Ala
465                 470                 475                 480 
Ala Val Ala Asp Val Thr Leu Gln Val His Tyr Tyr Asn Glu Ile His
                485                 490                 495     
Ala Val Trp Glu Pro Leu Ile Glu Arg Val Glu Gly Lys Arg Gln Trp
            500                 505                 510         
Asn Leu Arg Leu Asp Val Lys Lys Asn Pro Val Gln Asp Lys Ser Leu
        515                 520                 525             
Leu Pro Gly Asp Asp Phe Ile Pro Glu Pro Gln Met Ala Ile His Ile
    530                 535                 540                 
Ser Ser Gly Asn Thr Met Asn Ile Thr Ile Ser Lys Ser Cys Leu Asn
545                 550                 555                 560 
Val Phe Asn Asn Leu Ala Lys Gly Phe Ser Glu Gly Thr Ala Ser Thr
                565                 570                 575     
Phe Asp Tyr Ser Leu Lys Asp Arg Ala Pro Phe Thr Val Lys Asn Ala
            580                 585                 590         
Val Gly Val Pro Ile Lys Val Lys Pro Asn Cys Asn Leu Arg Val Met
        595                 600                 605             
Gly Phe Pro Glu Lys Ser Asp Ile Phe Asp Val Asp Ala Gly Gln Asn
    610                 615                 620                 
Leu Glu Leu Glu Tyr Ala Ser Met Val Pro Ser Ser Gln Gly Asn Leu
625                 630                 635                 640 
Ser Ile Leu Ser Arg Gln Glu Ser Ser Phe Phe Thr Leu Thr Ile Val
                645                 650                 655     
Pro His Gly Tyr Thr Glu Val Ala Asn Ile Pro Val Ala Arg Pro Gly
            660                 665                 670         
Arg Arg Leu Tyr Asn Val Arg Asn Pro Asn Ala Ser His Ser Asp Ser
        675                 680                 685             
Val Leu Val Gln Ile Asp Ala Thr Glu Gly Asn Lys Val Ile Thr Leu
    690                 695                 700                 
Arg Ser Pro Leu Gln Ile Lys Asn His Phe Ser Ile Ala Phe Ile Ile
705                 710                 715                 720 
Tyr Lys Phe Val Lys Asn Val Lys Leu Leu Glu Arg Ile Gly Ile Ala
                725                 730                 735     
Arg Pro Glu Glu Glu Phe His Val Pro Leu Asp Ser Tyr Arg Cys Gln
            740                 745                 750         
Leu Phe Ile Gln Pro Ala Gly Ile Leu Glu His Gln Tyr Lys Glu Ser
        755                 760                 765             
Thr Thr Tyr Ile Ser Trp Lys Glu Glu Leu His Arg Ser Arg Glu Val
    770                 775                 780                 
Arg Cys Met Leu Gln Cys Pro Ser Val Glu Val Ser Phe Leu Pro Leu
785                 790                 795                 800 
Ile Val Asn Thr Val Ala Leu Pro Asp Glu Leu Ser Tyr Ile Cys Thr
                805                 810                 815     
His Gly Glu Asp Trp Asp Val Ala Tyr Ile Ile His Leu Tyr Pro Ser
            820                 825                 830         
Leu Thr Leu Arg Asn Leu Leu Pro Tyr Ser Leu Arg Tyr Leu Leu Glu
        835                 840                 845             
Gly Thr Ala Glu Thr His Glu Leu Ala Glu Gly Ser Thr Ala Asp Val
    850                 855                 860                 
Leu His Ser Arg Ile Ser Gly Glu Ile Met Glu Leu Val Leu Val Lys
865                 870                 875                 880 
Tyr Gln Gly Lys Asn Trp Asn Gly His Phe Arg Ile Arg Asp Thr Leu
                885                 890                 895     
Pro Glu Phe Phe Pro Val Cys Phe Ser Ser Asp Ser Thr Glu Val Thr
            900                 905                 910         
Thr Val Asp Leu Ser Val His Val Arg Arg Ile Gly Ser Arg Met Val
        915                 920                 925             
Leu Ser Val Phe Ser Pro Tyr Trp Leu Ile Asn Lys Thr Thr Arg Val
    930                 935                 940                 
Leu Gln Tyr Arg Ser Glu Asp Ile His Val Lys His Pro Ala Asp Phe
945                 950                 955                 960 
Arg Asp Ile Ile Leu Phe Ser Phe Lys Lys Lys Asn Ile Phe Thr Lys
                965                 970                 975     
Asn Lys Val Gln Leu Lys Ile Ser Thr Ser Ala Trp Ser Ser Ser Phe
            980                 985                 990         
Ser Leu Asp Thr Val Gly Ser Tyr Gly Cys Val Lys Cys Pro Ala Asn
        995                 1000                1005            
Asn Met Glu Tyr Leu Val Gly Val Ser Ile Lys Met Ser Ser Phe Asn
    1010                1015                1020                
Leu Ser Arg Ile Val Thr Leu Thr Pro Phe Cys Thr Ile Ala Asn Lys
1025                1030                1035                1040
Ser Ser Leu Glu Leu Glu Val Gly Glu Ile Ala Ser Asp Gly Ser Met
                1045                1050                1055    
Pro Thr Asn Lys Trp Asn Tyr Ile Ala Ser Ser Glu Cys Leu Pro Phe
            1060                1065                1070        
Trp Pro Glu Ser Leu Ser Gly Lys Leu Cys Val Arg Val Val Gly Cys
        1075                1080                1085            
Glu Gly Ser Ser Lys Pro Phe Phe Tyr Asn Arg Gln Asp Asn Gly Thr
    1090                1095                1100                
Leu Leu Ser Leu Glu Asp Leu Asn Gly Gly Ile Leu Val Asp Val Asn
1105                1110                1115                1120
Thr Ala Glu His Ser Thr Val Ile Thr Phe Ser Asp Tyr His Glu Gly
                1125                1130                1135    
Ser Ala Pro Ala Leu Ile Met Asn His Thr Pro Trp Asp Ile Leu Thr
            1140                1145                1150        
Tyr Lys Gln Ser Gly Ser Pro Glu Glu Met Val Leu Leu Pro Arg Gln
        1155                1160                1165            
Ala Arg Leu Phe Ala Trp Ala Asp Pro Thr Gly Thr Arg Lys Leu Thr
    1170                1175                1180                
Trp Thr Tyr Ala Ala Asn Val Gly Glu His Asp Leu Leu Lys Asp Gly
1185                1190                1195                1200
Cys Gly Gln Phe Pro Tyr Asp Ala Asn Ile Gln Ile His Trp Val Ser
                1205                1210                1215    
Phe Leu Asp Gly Arg Gln Arg Val Leu Leu Phe Thr Asp Asp Val Ala
            1220                1225                1230        
Leu Val Ser Lys Ala Leu Gln Ala Glu Glu Met Glu Gln Ala Asp Tyr
        1235                1240                1245            
Glu Ile Thr Leu Ser Leu His Ser Leu Gly Leu Ser Leu Val Asn Asn
    1250                1255                1260                
Glu Ser Lys Gln Glu Val Ser Tyr Ile Gly Ile Thr Ser Ser Gly Val
1265                1270                1275                1280
Val Trp Glu Val Lys Pro Lys Gln Lys Trp Lys Pro Phe Ser Gln Lys
                1285                1290                1295    
Gln Ile Ile Leu Leu Glu Gln Ser Tyr Gln Lys His Gln Ile Ser Arg
            1300                1305                1310        
Asp His Gly Trp Ile Lys Leu Asp Asn Asn Phe Glu Val Asn Phe Asp
        1315                1320                1325            
Lys Asp Pro Met Glu Met Arg Leu Pro Ile Arg Ser Pro Ile Lys Arg
    1330                1335                1340                
Asp Phe Leu Ser Gly Ile Gln Ile Glu Phe Lys Gln Ser Ser His Gln
1345                1350                1355                1360
Arg Ser Leu Arg Ala Arg Leu Tyr Trp Leu Gln Val Asp Asn Gln Leu
                1365                1370                1375    
Pro Gly Ala Met Phe Pro Val Val Phe His Pro Val Ala Pro Pro Lys
            1380                1385                1390        
Ser Ile Ala Leu Asp Ser Glu Pro Lys Pro Phe Ile Asp Val Ser Val
        1395                1400                1405            
Ile Thr Arg Phe Asn Glu Tyr Ser Lys Val Leu Gln Phe Lys Tyr Phe
    1410                1415                1420                
Met Val Leu Ile Gln Glu Met Ala Leu Lys Ile Asp Gln Gly Phe Leu
1425                1430                1435                1440
Gly Ala Ile Ile Ala Leu Phe Thr Pro Thr Thr Asp Pro Glu Ala Glu
                1445                1450                1455    
Arg Arg Arg Thr Lys Leu Ile Gln Gln Asp Ile Asp Ala Leu Asn Ala
            1460                1465                1470        
Glu Leu Met Glu Thr Ser Met Thr Asp Met Ser Ile Leu Ser Phe Phe
        1475                1480                1485            
Glu His Phe His Ile Ser Pro Val Lys Leu His Leu Ser Leu Ser Leu
    1490                1495                1500                
Gly Ser Gly Gly Glu Glu Ser Asp Lys Glu Lys Gln Glu Met Phe Ala
1505                1510                1515                1520
Val His Ser Val Asn Leu Leu Leu Lys Ser Ile Gly Ala Thr Leu Thr
                1525                1530                1535    
Asp Val Asp Asp Leu Ile Phe Lys Leu Ala Tyr Tyr Glu Ile Arg Tyr
            1540                1545                1550        
Gln Phe Tyr Lys Arg Asp Gln Leu Ile Trp Ser Val Val Arg His Tyr
        1555                1560                1565            
Ser Glu Gln Phe Leu Lys Gln Met Tyr Val Leu Val Leu Gly Leu Asp
    1570                1575                1580                
Val Leu Gly Asn Pro Phe Gly Leu Ile Arg Gly Leu Ser Glu Gly Val
1585                1590                1595                1600
Glu Ala Leu Phe Tyr Glu Pro Phe Gln Gly Ala Val Gln Gly Pro Glu
                1605                1610                1615    
Glu Phe Ala Glu Gly Leu Val Ile Gly Val Arg Ser Leu Phe Gly His
            1620                1625                1630        
Thr Val Gly Gly Ala Ala Gly Val Val Ser Arg Ile Thr Gly Ser Val
        1635                1640                1645            
Gly Lys Gly Leu Ala Ala Ile Thr Met Asp Lys Glu Tyr Gln Gln Lys
    1650                1655                1660                
Arg Arg Glu Glu Leu Ser Arg Gln Pro Arg Asp Phe Gly Asp Ser Leu
1665                1670                1675                1680
Ala Arg Gly Gly Lys Gly Phe Leu Arg Gly Val Val Gly Gly Val Thr
                1685                1690                1695    
Gly Ile Ile Thr Lys Pro Val Glu Gly Ala Lys Lys Glu Gly Ala Ala
            1700                1705                1710        
Gly Phe Phe Lys Gly Ile Gly Lys Gly Leu Val Gly Ala Val Ala Arg
        1715                1720                1725            
Pro Thr Gly Gly Ile Val Asp Met Ala Ser Ser Thr Phe Gln Gly Ile
    1730                1735                1740                
Gln Arg Ala Ala Glu Ser Thr Glu Glu Val Ser Ser Leu Arg Pro Pro
1745                1750                1755                1760
Arg Leu Ile His Glu Asp Gly Ile Ile Arg Pro Tyr Asp Arg Gln Glu
                1765                1770                1775    
Ser Glu Gly Ser Asp Leu Leu Glu Asn His Ile Lys Lys Leu Glu Gly
            1780                1785                1790        
Glu Thr Tyr Arg Tyr His Cys Ala Ile Pro Gly Ser Lys Lys Thr Ile
        1795                1800                1805            
Leu Met Val Thr Asn Arg Arg Val Leu Cys Ile Lys Glu Val Glu Ile
    1810                1815                1820                
Leu Gly Leu Met Cys Val Asp Trp Gln Cys Pro Phe Glu Asp Phe Val
1825                1830                1835                1840
Phe Pro Pro Ser Val Ser Glu Asn Val Leu Lys Ile Ser Val Lys Glu
                1845                1850                1855    
Gln Gly Leu Phe His Lys Lys Asp Ser Ala Asn Gln Gly Cys Val Arg
            1860                1865                1870        
Lys Val Tyr Leu Lys Asp Thr Ala Thr Ala Glu Arg Ala Cys Asn Ala
        1875                1880                1885            
Ile Glu Asp Ala Gln Ser Thr Arg Gln Gln Gln Lys Leu Met Lys Gln
    1890                1895                1900                
Ser Ser Val Arg Leu Leu Arg Pro Gln Leu Pro Ser
1905                1910                1915    


<210> 7309
<211> 875
<212> PRT
<213> Homo sapiens

<400> 7309
Met Lys Pro Ser Thr Phe Ile Asn Arg Ser Asn Ser Cys Gln Lys Thr
 1               5                  10                  15      
Leu Ile Pro Gly Val Cys Tyr Ser Gly Gln Trp Gln Pro Glu Pro Gly
            20                  25                  30          
Pro Arg Ser Leu Gln Gln Ser Arg Leu His His His Cys Ser Gln Ile
        35                  40                  45              
Gly Gly Val Gly Ser Ala Asn Ser Ser Ala Asp Ser Thr Ile Ser Val
    50                  55                  60                  
Ile Ser Gly Ser Leu Ser His Ser Glu Pro Ser His Gly Leu Ala Asp
65                  70                  75                  80  
Arg Val Ile Asn Cys Arg Glu Val Leu Glu Ala Phe Asn Leu Leu Val
                85                  90                  95      
Leu Gln Val Ser Ser Phe Pro Tyr Thr Leu Gln Thr Gln Gln Ser Arg
            100                 105                 110         
Ile Ser Ser Ser Asn Glu Val His Trp Ile Gln Leu Asp Thr Gly Glu
        115                 120                 125             
Asp Val Gly Cys Glu Glu Lys Leu Tyr Phe Gly Leu Ser Glu Tyr Ser
    130                 135                 140                 
Lys Ser Leu Gln Trp Gly Ile Thr Ser Pro Leu Leu Arg Cys Asp Glu
145                 150                 155                 160 
Thr Phe Glu Lys Met Val Asn Thr Leu Leu Glu Arg Tyr Pro Arg Leu
                165                 170                 175     
His Ser Met Val Val Arg Cys Tyr Leu Leu Ile Gln Gln Tyr Ser Glu
            180                 185                 190         
Ala Leu Met Ala Leu Thr Thr Met Ala Ser Leu Arg Asp His Ser Thr
        195                 200                 205             
Pro Glu Thr Leu Ser Ile Met Asp Asp Leu Ile Ser Ser Pro Gly Lys
    210                 215                 220                 
Asn Lys Ser Gly Arg Gly His Met Leu Ile Ile Arg Val Pro Ser Val
225                 230                 235                 240 
Gln Leu Ala Met Leu Ala Lys Glu Arg Leu Gln Glu Val Arg Asp Lys
                245                 250                 255     
Leu Gly Leu Gln Tyr Arg Phe Glu Ile Ile Leu Gly Asn Pro Ala Thr
            260                 265                 270         
Glu Leu Ser Val Ala Thr His Phe Val Ala Arg Leu Lys Ser Trp Arg
        275                 280                 285             
Gly Asn Glu Pro Glu Glu Trp Ile Pro Arg Thr Tyr Gln Asp Leu Asp
    290                 295                 300                 
Gly Leu Pro Cys Ile Val Ile Leu Thr Gly Lys Asp Pro Leu Gly Glu
305                 310                 315                 320 
Thr Phe Pro Arg Ser Leu Lys Tyr Cys Asp Leu Arg Leu Ile Asp Ser
                325                 330                 335     
Ser Tyr Leu Thr Arg Thr Ala Leu Glu Gln Glu Val Gly Leu Ala Cys
            340                 345                 350         
Cys Tyr Val Ser Lys Glu Val Ile Arg Gly Pro Thr Val Ala Leu Asp
        355                 360                 365             
Leu Ser Gly Lys Glu Gln Glu Arg Ala Ala Val Ser Glu Asn Asp Ser
    370                 375                 380                 
Asp Glu Leu Leu Ile Asp Leu Glu Arg Pro Gln Ser Asn Ser Ser Ala
385                 390                 395                 400 
Val Thr Gly Thr Ser Gly Ser Ile Met Glu Asn Gly Val Ser Ser Ser
                405                 410                 415     
Asn Thr Ala Asp Lys Ser Gln Lys Gln Ser Leu Thr Pro Ser Phe Gln
            420                 425                 430         
Ser Pro Ala Thr Ser Leu Gly Leu Asp Glu Gly Val Ser Ala Ser Ser
        435                 440                 445             
Ala Gly Ala Gly Ala Gly Glu Thr Leu Lys Gln Glu Cys Asp Ser Leu
    450                 455                 460                 
Gly Pro Gln Met Ala Ser Ser Thr Thr Ser Lys Pro Ser Ser Ser Ser
465                 470                 475                 480 
Ser Gly Pro Arg Thr Leu Pro Trp Pro Gly Gln Pro Ile Arg Gly Cys
                485                 490                 495     
Arg Gly Pro Gln Ala Ala Leu Pro Pro Val Val Ile Leu Ser Lys Ala
            500                 505                 510         
Ala Tyr Ser Leu Leu Gly Ser Gln Lys Ser Gly Lys Leu Pro Ser Ser
        515                 520                 525             
Ser Ser Leu Leu Pro His Ala Asp Val Ala Trp Val Ser Ser Leu Arg
    530                 535                 540                 
Pro Leu Leu Asn Lys Asp Met Ser Ser Glu Glu Gln Ser Leu Tyr Tyr
545                 550                 555                 560 
Arg Gln Trp Thr Leu Ala Arg Gln His His Ala Asp Tyr Ser Asn Gln
                565                 570                 575     
Leu Asp Pro Ala Ser Gly Thr Arg Asn Phe His Pro Arg Arg Leu Leu
            580                 585                 590         
Leu Thr Gly Pro Pro Gln Val Gly Lys Thr Gly Ser Tyr Leu Gln Phe
        595                 600                 605             
Leu Arg Ile Leu Phe Arg Met Leu Ile Arg Leu Leu Glu Val Asp Val
    610                 615                 620                 
Tyr Asp Glu Glu Glu Ile Asn Thr Asp His Asn Glu Ser Ser Glu Val
625                 630                 635                 640 
Ser Gln Ser Glu Gly Glu Pro Trp Pro Asp Ile Glu Ser Phe Ser Lys
                645                 650                 655     
Met Pro Phe Asp Val Ser Val His Asp Pro Lys Tyr Ser Leu Met Ser
            660                 665                 670         
Leu Val Tyr Thr Glu Lys Leu Ala Gly Val Lys Gln Glu Val Ile Lys
        675                 680                 685             
Glu Ser Lys Val Glu Glu Pro Arg Lys Arg Glu Thr Val Ser Ile Met
    690                 695                 700                 
Leu Thr Lys Tyr Ala Ala Tyr Asn Thr Phe His His Cys Glu Gln Cys
705                 710                 715                 720 
Arg Gln Tyr Met Asp Phe Thr Ser Ala Ser Gln Met Ser Asp Ser Thr
                725                 730                 735     
Leu His Ala Phe Thr Phe Ser Ser Ser Met Leu Gly Glu Glu Val Gln
            740                 745                 750         
Leu Tyr Phe Ile Ile Pro Lys Ser Lys Glu Ser His Phe Val Phe Ser
        755                 760                 765             
Lys Gln Gly Lys His Leu Glu Ser Met Arg Leu Pro Leu Val Ser Asp
    770                 775                 780                 
Lys Asn Leu Asn Ala Val Lys Ser Pro Ile Phe Thr Pro Ser Ser Gly
785                 790                 795                 800 
Arg His Glu His Gly Leu Leu Asn Leu Phe His Ala Met Glu Gly Ile
                805                 810                 815     
Ser His Leu His Leu Leu Val Val Lys Glu Tyr Glu Met Pro Leu Tyr
            820                 825                 830         
Arg Lys Tyr Trp Pro Asn His Ile Met Leu Val Leu Pro Gly Met Phe
        835                 840                 845             
Asn Asn Ala Gly Val Gly Lys Gly Pro Pro Trp Asp Gly Glu Lys Gly
    850                 855                 860                 
Phe Glu Asp Lys Leu Ser Ser Ile Pro Leu Ala
865                 870                 875 


<210> 7310
<211> 1036
<212> PRT
<213> Homo sapiens

<400> 7310
Met Glu Val Val Gly Asp Phe Glu Tyr Ser Lys Arg Asp Leu Val Gly
 1               5                  10                  15      
His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr
            20                  25                  30          
Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys
        35                  40                  45              
Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln
    50                  55                  60                  
His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser
65                  70                  75                  80  
Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr
                85                  90                  95      
Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu
            100                 105                 110         
His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile
        115                 120                 125             
His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg
    130                 135                 140                 
Arg Lys Ser Ser Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly
145                 150                 155                 160 
Phe Ala Arg Tyr Leu His Ser Asn Met Met Ala Ala Thr Leu Cys Gly
                165                 170                 175     
Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp
            180                 185                 190         
Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu
        195                 200                 205             
Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met
    210                 215                 220                 
Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr
225                 230                 235                 240 
Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln
                245                 250                 255     
Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu
            260                 265                 270         
Gln Gly Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Met Tyr Ser
        275                 280                 285             
Gly Ser Val Ser Gly Ser Ser Cys Gly Ser Ser Pro Ser Cys Arg Phe
    290                 295                 300                 
Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn
305                 310                 315                 320 
Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys
                325                 330                 335     
Asp Ser Ala Ser Thr Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp
            340                 345                 350         
Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Cys Asp Met
        355                 360                 365             
Pro Met Gly Thr Ala Gly Arg Arg Ala Ser Asn Glu Phe Leu Val Cys
    370                 375                 380                 
Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro
385                 390                 395                 400 
Ile Pro Val Pro Thr Gln Ile Arg Asn Tyr Gln Arg Ile Glu Gln Asn
                405                 410                 415     
Leu Thr Ser Thr Ala Ser Ser Gly Thr Asn Val His Gly Ser Pro Arg
            420                 425                 430         
Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg
        435                 440                 445             
Pro Gly Ser Cys Ser Pro Val Pro Ala Asp Thr Ala Gln Thr Val Gly
    450                 455                 460                 
Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu
465                 470                 475                 480 
Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro
                485                 490                 495     
Gln Gly His Asp Ser Arg Ser Arg Asn Ser Ser Gly Ser Pro Val Pro
            500                 505                 510         
Gln Ala Gln Ser Pro Gln Ser Leu Leu Ser Gly Ala Arg Leu Gln Ser
        515                 520                 525             
Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys
    530                 535                 540                 
Gln His Ser Asp Pro Val Cys Pro Ser His Thr Gly Ala Gly Tyr Ser
545                 550                 555                 560 
Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr
                565                 570                 575     
Lys His Leu Gly Ser Ser Pro Arg Ser Ser Asp Trp Phe Phe Lys Thr
            580                 585                 590         
Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe
        595                 600                 605             
Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr
    610                 615                 620                 
Arg His Gly Pro Ala Glu Glu Gln Ser Lys Asp Gly Asn Glu Pro Arg
625                 630                 635                 640 
Glu Cys Ala His Cys Leu Leu Val Gln Gly Ser Glu Arg Gln Arg Ala
                645                 650                 655     
Glu Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly Lys
            660                 665                 670         
Leu Ser Asp Gln Gln Gly Lys Thr Pro Ile Cys Arg His Gln Gly Ser
        675                 680                 685             
Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Ile Ala Pro Ala Gly
    690                 695                 700                 
Ala Cys Gly Gly Val Leu Ala Pro Pro Ala Gly Thr Ala Ala Ser Ser
705                 710                 715                 720 
Lys Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Ala Ala
                725                 730                 735     
Pro Thr Cys Thr His Met Phe Leu Arg Thr Arg Thr Thr Ser Val Gly
            740                 745                 750         
Pro Ser Asn Ser Gly Gly Ser Leu Cys Ala Met Ser Gly Arg Val Cys
        755                 760                 765             
Val Gly Ser Pro Pro Gly Pro Gly Phe Gly Ser Ser Pro Pro Gly Ala
    770                 775                 780                 
Glu Ala Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro Pro
785                 790                 795                 800 
Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu Glu
                805                 810                 815     
Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn Val
            820                 825                 830         
Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Met Arg Gly
        835                 840                 845             
Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile Gln
    850                 855                 860                 
Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp Gly
865                 870                 875                 880 
Arg Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu Ala
                885                 890                 895     
Ala Ser Leu His Leu Ala Lys Ala Gln Ile Lys Ser Gly Lys Leu Ser
            900                 905                 910         
Pro Ser Thr Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg Tyr
        915                 920                 925             
Lys Phe Cys Ile Thr Met Cys Lys Lys Leu Thr Glu Lys Leu Asn Arg
    930                 935                 940                 
Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val Thr
945                 950                 955                 960 
Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser Ala
                965                 970                 975     
Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg Tyr
            980                 985                 990         
His Lys Ala Ala Leu Leu Leu Glu Gly Leu Ser Arg Ile Leu Gln Asp
        995                 1000                1005            
Pro Ala Asp Ile Glu Asn Val His Lys Tyr Lys Cys Ser Ile Glu Arg
    1010                1015                1020                
Arg Leu Ser Ala Leu Cys His Ser Thr Ala Thr Val
1025                1030                1035    


<210> 7311
<211> 1036
<212> PRT
<213> Homo sapiens

<400> 7311
Met Glu Val Val Gly Asp Phe Glu Tyr Ser Lys Arg Asp Leu Val Gly
 1               5                  10                  15      
His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr
            20                  25                  30          
Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys
        35                  40                  45              
Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln
    50                  55                  60                  
His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser
65                  70                  75                  80  
Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr
                85                  90                  95      
Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu
            100                 105                 110         
His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile
        115                 120                 125             
His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg
    130                 135                 140                 
Arg Lys Ser Ser Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly
145                 150                 155                 160 
Phe Ala Arg Tyr Leu His Ser Asn Met Met Ala Ala Thr Leu Cys Gly
                165                 170                 175     
Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp
            180                 185                 190         
Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu
        195                 200                 205             
Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met
    210                 215                 220                 
Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr
225                 230                 235                 240 
Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln
                245                 250                 255     
Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu
            260                 265                 270         
Gln Gly Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Met Tyr Ser
        275                 280                 285             
Gly Ser Val Ser Gly Ser Ser Cys Gly Ser Ser Pro Ser Cys Arg Phe
    290                 295                 300                 
Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn
305                 310                 315                 320 
Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys
                325                 330                 335     
Asp Ser Ala Ser Thr Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp
            340                 345                 350         
Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Cys Asp Met
        355                 360                 365             
Pro Met Gly Thr Ala Gly Arg Arg Ala Ser Asn Glu Phe Leu Val Cys
    370                 375                 380                 
Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro
385                 390                 395                 400 
Ile Pro Val Pro Thr Gln Ile Arg Asn Tyr Gln Arg Ile Glu Gln Asn
                405                 410                 415     
Leu Thr Ser Thr Ala Ser Ser Gly Thr Asn Val His Gly Ser Pro Arg
            420                 425                 430         
Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg
        435                 440                 445             
Pro Gly Ser Cys Ser Pro Val Pro Ala Asp Thr Ala Gln Thr Val Gly
    450                 455                 460                 
Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu
465                 470                 475                 480 
Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro
                485                 490                 495     
Gln Gly His Asp Ser Arg Ser Arg Asn Ser Ser Gly Ser Pro Val Pro
            500                 505                 510         
Gln Ala Gln Ser Pro Gln Ser Leu Leu Ser Gly Ala Arg Leu Gln Ser
        515                 520                 525             
Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys
    530                 535                 540                 
Gln His Ser Asp Pro Val Cys Pro Ser His Thr Gly Ala Gly Tyr Ser
545                 550                 555                 560 
Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr
                565                 570                 575     
Lys His Leu Gly Ser Ser Pro Arg Ser Ser Asp Trp Phe Phe Lys Thr
            580                 585                 590         
Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe
        595                 600                 605             
Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr
    610                 615                 620                 
Arg His Gly Pro Ala Glu Glu Gln Ser Lys Asp Gly Asn Glu Pro Arg
625                 630                 635                 640 
Glu Cys Ala His Cys Leu Leu Val Gln Gly Ser Glu Arg Gln Arg Ala
                645                 650                 655     
Glu Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly Lys
            660                 665                 670         
Leu Ser Asp Gln Gln Gly Lys Thr Pro Ile Cys Arg His Gln Gly Ser
        675                 680                 685             
Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Ile Ala Pro Ala Gly
    690                 695                 700                 
Ala Cys Gly Gly Val Leu Ala Pro Pro Ala Gly Thr Ala Ala Ser Ser
705                 710                 715                 720 
Lys Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Ala Ala
                725                 730                 735     
Pro Thr Cys Thr His Met Phe Leu Arg Thr Arg Thr Thr Ser Val Gly
            740                 745                 750         
Pro Ser Asn Ser Gly Gly Ser Leu Cys Ala Met Ser Gly Arg Val Cys
        755                 760                 765             
Val Gly Ser Pro Pro Gly Pro Gly Phe Gly Ser Ser Pro Pro Gly Ala
    770                 775                 780                 
Glu Ala Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro Pro
785                 790                 795                 800 
Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu Glu
                805                 810                 815     
Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn Val
            820                 825                 830         
Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Met Arg Gly
        835                 840                 845             
Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile Gln
    850                 855                 860                 
Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp Gly
865                 870                 875                 880 
Arg Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu Ala
                885                 890                 895     
Ala Ser Leu His Leu Ala Lys Ala Gln Ile Lys Ser Gly Lys Leu Ser
            900                 905                 910         
Pro Ser Thr Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg Tyr
        915                 920                 925             
Lys Phe Cys Ile Thr Met Arg Lys Lys Leu Thr Glu Lys Leu Asn Arg
    930                 935                 940                 
Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val Thr
945                 950                 955                 960 
Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser Ala
                965                 970                 975     
Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg Tyr
            980                 985                 990         
His Lys Ala Ala Leu Leu Leu Glu Gly Leu Ser Arg Ile Leu Gln Asp
        995                 1000                1005            
Pro Ala Asp Ile Glu Asn Val His Lys Tyr Lys Cys Ser Ile Glu Arg
    1010                1015                1020                
Arg Leu Ser Ala Leu Cys His Ser Thr Ala Thr Val
1025                1030                1035    


<210> 7312
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 7312
Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn Pro Ser Cys Lys Ile
 1               5                  10                  15      
Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg Glu Phe Asn Lys Tyr
            20                  25                  30          
Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg Ala Gly Leu Ala Lys
        35                  40                  45              
Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Cys Tyr Asp Asp Ile
    50                  55                  60                  
Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln Met Val Thr Gly Gln
65                  70                  75                  80  
Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val
                85                  90                  95      
Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys Tyr Cys Thr Pro Arg
            100                 105                 110         
Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr
        115                 120                 125             
Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn Gly Ser Ile Tyr Asp
    130                 135                 140                 
Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Ile Asn Thr Val Leu Asp
145                 150                 155                 160 
Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu Gly Val Asn Thr Pro
                165                 170                 175     
Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu
            180                 185                 190         
Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys
        195                 200                 205             
Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu
    210                 215                 220                 
Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly Cys Asp Ala Phe Leu
225                 230                 235                 240 
Arg His Lys Met Thr Leu Ile Ser Pro Ser Val Leu Lys Lys Tyr Gly
                245                 250                 255     
Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr
            260                 265                 270         
Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala
        275                 280                 285             
Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile Asp Tyr Gly Lys Val
    290                 295                 300                 
Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp
305                 310                 315                 320 
Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr Gln Leu Trp Lys Gln
                325                 330                 335     
Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys Pro Thr Pro Ala Ser
            340                 345                 350         
Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg Arg Lys Val Arg Lys
        355                 360                 365             
Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr Ser Lys Arg Pro Lys
    370                 375                 380                 
Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val Asp Gly Ala Glu Val
385                 390                 395                 400 
Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys Val Ser Glu Lys Ser
                405                 410                 415     
Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu
            420                 425                 430         
Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn Leu Ser Asp His Ile
        435                 440                 445             
Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser Val Thr Glu Asp Ile
    450                 455                 460                 
Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg Ser Val Pro Ser Ile
465                 470                 475                 480 
Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser Thr Gly Tyr Glu Lys
                485                 490                 495     
Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp Pro Lys Ser Pro Glu
            500                 505                 510         
Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val Leu Thr Glu Gly Glu
        515                 520                 525             
Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu Glu Pro Gly Glu Ile
    530                 535                 540                 
Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe Lys Val Pro Ser Ile
545                 550                 555                 560 
Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp Arg His Pro Leu Ser
                565                 570                 575     
Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val Lys Gln Gln Ala Pro
            580                 585                 590         
Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile Glu Glu Glu Val Glu
        595                 600                 605             
Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His Leu Trp Gln Thr Lys
    610                 615                 620                 
Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn Ala Thr Val Ala Arg
625                 630                 635                 640 
Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu Met Pro Tyr His Lys
                645                 650                 655     
Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg Trp Glu Thr Lys Leu
            660                 665                 670         
Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys Pro Leu Ile Pro Glu
        675                 680                 685             
Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu Tyr Ser Pro Pro Asn
    690                 695                 700                 
Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu Ile Ser Cys Ala Lys
705                 710                 715                 720 
Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly Ile Pro Ser His Glu
                725                 730                 735     
Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys Arg Asn Ala Trp Thr
            740                 745                 750         
Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly Ala Leu Lys Gln Thr
        755                 760                 765             
Lys Asn Asn Arg Trp Ala His Val Met Cys Ala Val Ala Val Pro Glu
    770                 775                 780                 
Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln Ile Asp Val Gly Arg
785                 790                 795                 800 
Ile Pro Leu Gln Arg Leu Lys Leu Lys Cys Ile Phe Cys Arg His Arg
                805                 810                 815     
Val Lys Arg Val Ser Gly Ala Cys Ile Gln Cys Ser Tyr Gly Arg Cys
            820                 825                 830         
Pro Ala Ser Phe His Val Thr Cys Ala His Ala Ala Gly Val Leu Met
        835                 840                 845             
Glu Pro Asp Asp Trp Pro Tyr Val Val Asn Ile Thr Cys Phe Arg His
    850                 855                 860                 
Lys Val Asn Pro Asn Val Lys Ser Lys Ala Cys Glu Lys Val Ile Ser
865                 870                 875                 880 
Val Gly Gln Thr Val Ile Thr Lys His Arg Asn Thr Arg Tyr Tyr Ser
                885                 890                 895     
Cys Arg Val Met Ala Val Thr Ser Gln Thr Phe Tyr Glu Val Met Phe
            900                 905                 910         
Asp Asp Gly Ser Phe Ser Arg Asp Thr Phe Pro Glu Asp Ile Val Ser
        915                 920                 925             
Arg Asp Cys Leu Lys Leu Gly Pro Pro Ala Glu Gly Glu Val Val Gln
    930                 935                 940                 
Val Lys Trp Pro Asp Gly Lys Leu Tyr Gly Ala Lys Tyr Phe Gly Ser
945                 950                 955                 960 
Asn Ile Ala His Met Tyr Gln Val Glu Phe Glu Asp Gly Ser Gln Ile
                965                 970                 975     
Ala Met Lys Arg Glu Asp Ile Tyr Thr Leu Asp Glu Glu Leu Pro Lys
            980                 985                 990         
Arg Val Lys Ala Arg Phe Ser Thr Ala Ser Asp Met Arg Phe Glu Asp
        995                 1000                1005            
Thr Phe Tyr Gly Ala Asp Ile Ile Gln Gly Glu Arg Lys Arg Gln Arg
    1010                1015                1020                
Val Leu Ser Ser Arg Phe Lys Asn Glu Tyr Val Ala Asp Pro Val Tyr
1025                1030                1035                1040
Arg Thr Phe Leu Lys Ser Ser Phe Gln Lys Lys Cys Gln Lys Arg Gln
                1045                1050                1055    


<210> 7313
<211> 1100
<212> PRT
<213> Homo sapiens

<400> 7313
Gly Pro Val Arg Val Arg Ser Glu Gln Leu Ser Pro Ser Ala Glu Gln
 1               5                  10                  15      
Val Ser Gln Ile Ser Gln Ile Ser Leu Gly Arg Arg Pro Leu Ser Ser
            20                  25                  30          
Leu Pro Pro Pro Pro Ser Arg Ala Leu Ala Pro Thr Arg Ala Pro Asp
        35                  40                  45              
Thr Ala Leu Thr Ile Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn
    50                  55                  60                  
Pro Ser Cys Lys Ile Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg
65                  70                  75                  80  
Glu Phe Asn Lys Tyr Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg
                85                  90                  95      
Ala Gly Leu Ala Lys Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln
            100                 105                 110         
Cys Tyr Asp Asp Ile Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln
        115                 120                 125             
Met Val Thr Gly Gln Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys
    130                 135                 140                 
Lys Ala Met Thr Val Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys
145                 150                 155                 160 
Tyr Cys Thr Pro Arg Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr
                165                 170                 175     
Trp Lys Asn Leu Thr Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn
            180                 185                 190         
Gly Ser Ile Tyr Asp Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Leu
        195                 200                 205             
Asn Thr Val Leu Asp Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu
    210                 215                 220                 
Gly Val Asn Thr Pro Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe
225                 230                 235                 240 
Ala Trp His Thr Glu Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His
                245                 250                 255     
Phe Gly Glu Pro Lys Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys
            260                 265                 270         
Arg Leu Glu Arg Leu Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly
        275                 280                 285             
Cys Asp Ala Phe Leu Arg His Lys Met Thr Leu Ile Ser Pro Ser Val
    290                 295                 300                 
Leu Lys Lys Tyr Gly Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly
305                 310                 315                 320 
Glu Phe Met Ile Thr Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His
                325                 330                 335     
Gly Phe Asn Cys Ala Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile
            340                 345                 350         
Asp Tyr Gly Lys Val Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val
        355                 360                 365             
Lys Ile Ser Met Asp Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr
    370                 375                 380                 
Gln Leu Trp Lys Gln Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys
385                 390                 395                 400 
Pro Thr Pro Ala Ser Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg
                405                 410                 415     
Arg Lys Val Arg Lys Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr
            420                 425                 430         
Ser Lys Arg Pro Lys Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val
        435                 440                 445             
Asp Gly Ala Glu Val Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys
    450                 455                 460                 
Val Ser Glu Lys Ser Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala
465                 470                 475                 480 
Ser Ser Glu Glu Glu Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn
                485                 490                 495     
Leu Ser Asp His Ile Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser
            500                 505                 510         
Val Thr Glu Asp Ile Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg
        515                 520                 525             
Ser Val Pro Ser Ile Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser
    530                 535                 540                 
Thr Gly Tyr Glu Lys Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp
545                 550                 555                 560 
Pro Lys Ser Pro Glu Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val
                565                 570                 575     
Leu Thr Glu Gly Glu Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu
            580                 585                 590         
Glu Pro Gly Glu Ile Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe
        595                 600                 605             
Lys Val Pro Ser Ile Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp
    610                 615                 620                 
Arg His Pro Leu Ser Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val
625                 630                 635                 640 
Lys Gln Gln Ala Pro Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile
                645                 650                 655     
Glu Glu Glu Val Glu Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His
            660                 665                 670         
Leu Trp Gln Thr Lys Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn
        675                 680                 685             
Ala Thr Val Ala Arg Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu
    690                 695                 700                 
Met Pro Tyr His Lys Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg
705                 710                 715                 720 
Trp Glu Thr Lys Leu Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys
                725                 730                 735     
Pro Leu Ile Pro Glu Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu
            740                 745                 750         
Tyr Ser Pro Pro Asn Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu
        755                 760                 765             
Ile Ser Cys Ala Lys Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly
    770                 775                 780                 
Ile Pro Ser His Glu Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys
785                 790                 795                 800 
Arg Asn Ala Trp Thr Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly
                805                 810                 815     
Ala Leu Lys Gln Thr Lys Asn Asn Lys Trp Ala His Val Met Cys Ala
            820                 825                 830         
Val Ala Val Pro Glu Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln
        835                 840                 845             
Ile Asp Val Gly Arg Ile Pro Leu Gln Arg Leu Lys Leu Lys Cys Ile
    850                 855                 860                 
Phe Cys Arg His Arg Val Lys Arg Val Ser Gly Ala Cys Ile Gln Cys
865                 870                 875                 880 
Ser Tyr Gly Arg Cys Pro Ala Ser Phe His Val Thr Cys Ala His Ala
                885                 890                 895     
Ala Gly Val Leu Met Glu Pro Asp Asp Trp Pro Tyr Val Val Asn Ile
            900                 905                 910         
Thr Cys Phe Arg His Lys Val Asn Pro Asn Val Lys Ser Lys Ala Cys
        915                 920                 925             
Glu Lys Val Ile Ser Val Gly Gln Thr Val Ile Thr Lys His Arg Asn
    930                 935                 940                 
Thr Arg Tyr Tyr Ser Cys Arg Val Met Ala Val Thr Ser Gln Thr Phe
945                 950                 955                 960 
Tyr Glu Val Met Phe Asp Asp Gly Ser Phe Ser Arg Asp Thr Phe Pro
                965                 970                 975     
Glu Asp Ile Val Ser Arg Asp Cys Leu Lys Leu Gly Pro Pro Ala Glu
            980                 985                 990         
Gly Glu Val Val Gln Val Lys Trp Pro Asp Gly Lys Leu Tyr Gly Ala
        995                 1000                1005            
Lys Tyr Phe Gly Ser Asn Ile Ala His Met Tyr Gln Val Glu Phe Glu
    1010                1015                1020                
Asp Gly Ser Gln Ile Ala Met Lys Arg Glu Asp Ile Tyr Thr Leu Asp
1025                1030                1035                1040
Glu Glu Leu Pro Lys Arg Val Lys Ala Arg Phe Val Ser Ala Gly Arg
                1045                1050                1055    
Cys His Leu Gly Thr Cys Gln Val Asn Ser Leu Ser Ser Pro His Val
            1060                1065                1070        
Ser Gln Ala Gln Gln Glu Thr Tyr Leu Gly Phe Trp Ile Asn Ser Lys
        1075                1080                1085            
Lys Ser Gln Cys Asn Ile Phe Leu Ser Gly Thr Tyr
    1090                1095                1100


<210> 7314
<211> 392
<212> PRT
<213> Homo sapiens

<400> 7314
Met Asn Cys Phe Ser Phe Gln Leu Tyr His Gly Val Ser Glu Ser Ala
 1               5                  10                  15      
Asn Leu Ala Gly Thr Phe Cys Gly Ser Thr Val Pro Ala Pro Phe Ile
            20                  25                  30          
Ser Ser Gly Asn Phe Leu Met Val Gln Phe Ile Ser Asp Leu Thr Leu
        35                  40                  45              
Glu Arg Glu Gly Phe Asn Ala Thr Tyr Thr Ile Met Asp Met Pro Cys
    50                  55                  60                  
Gly Gly Thr Tyr Asn Ala Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro
65                  70                  75                  80  
Asn Ser Ser Asp Pro Asp Val Pro Phe Ser Ile Cys Thr Trp Val Ile
                85                  90                  95      
Asp Thr Pro Pro His Gln Gln Val Lys Ile Thr Val Trp Val Leu Thr
            100                 105                 110         
Ala Glu Leu Ile Arg Leu His Ala Glu Leu Leu Thr Ala Ser Gly Leu
        115                 120                 125             
Thr Thr Gly Gln Asn Pro Tyr Tyr Pro Val Val Pro Leu Leu Glu Gly
    130                 135                 140                 
Leu Arg Ala Lys Trp Asn Lys Ser His Gly Asn Ser Arg Ile Gln Phe
145                 150                 155                 160 
Cys Gly Arg Asn Ala Leu Ala Met Pro Val Phe Tyr Ser Ser Met Ser
                165                 170                 175     
Thr Ala Ile Val Ile Phe Lys Ser Gly Val Leu Asn Arg Asn Ser Arg
            180                 185                 190         
Met Asn Phe Thr Tyr Gln Ile Ala Asp Cys Asn Arg Asp Tyr His Lys
        195                 200                 205             
Ala Phe Gly Asn Leu Arg Ser Thr Gly Trp Pro Asp Asn Tyr Asp Ser
    210                 215                 220                 
Asp Met Asp Cys Thr Ile Thr Leu Thr Ala Pro His Asn His Thr Leu
225                 230                 235                 240 
Phe Phe His Leu Phe Gly Ile Glu Asn Ser Ile Glu Cys Arg Asn Asp
                245                 250                 255     
Phe Leu Glu Ser Asn Ser Val Ile Ser Asp Arg Gly Tyr Glu Ile Ile
            260                 265                 270         
Trp Thr Ser Ser Pro Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg
        275                 280                 285             
Gly Ser Phe Thr Ser Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr
    290                 295                 300                 
Asn Cys Glu Trp Ala Leu Val Ala Pro Ala Gly Arg Leu Leu Thr Val
305                 310                 315                 320 
Asn Phe Tyr Phe Ile Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn
                325                 330                 335     
Tyr Leu Thr Leu Tyr Asp Gly Pro Asn Val Ser Ser Pro Ser Tyr Gly
            340                 345                 350         
Pro Tyr Cys Arg Gly Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser
        355                 360                 365             
Asn Gln Val Phe Ile Lys Phe His Ala Ala Tyr Ala Trp His Pro Ser
    370                 375                 380                 
Thr Leu Gln Leu Thr Trp Asp Cys
385                 390         


<210> 7315
<211> 1579
<212> PRT
<213> Homo sapiens

<400> 7315
Met Gly His Asn Cys Lys Met Pro Arg Thr Gly Ala Gln Asp Gly Ala
 1               5                  10                  15      
Trp Ile Gln Lys Gln Val Val Phe Glu Gly Gln Met Ala Ser Thr Tyr
            20                  25                  30          
Glu Gln Asp Glu Val Ile Ala Ile Asp Asp Ile Ser Phe Ser Ser Gly
        35                  40                  45              
Cys Leu Pro Ala Asn Asp Gly Ile Leu Leu Cys Gln Glu Ala Leu Asn
    50                  55                  60                  
Ala Glu Arg Glu Leu Cys His Pro Asp Thr Asp Leu Cys Arg Phe Asp
65                  70                  75                  80  
Ala Thr Asp Glu Glu Leu Arg Leu Cys Gln Ala Cys Gly Phe Glu Phe
                85                  90                  95      
Asp Met Cys Glu Trp Thr Ser Glu Ala Ser Ala Gly Gln Ile Ser Trp
            100                 105                 110         
Met Arg Thr Lys Ala Arg Glu Ile Pro Ala Phe Glu Ser Thr Pro Gln
        115                 120                 125             
Gln Asp Gln Gly Gly Asp Asp Glu Gly Tyr Tyr Val Trp Val Gly Ala
    130                 135                 140                 
Lys His Gly Phe Thr Leu Asn His Leu Asp Ser Arg Ala Tyr Leu Asn
145                 150                 155                 160 
Ser Ser Val Cys His Cys Leu Gly Lys Ser Cys His Leu Gln Phe Tyr
                165                 170                 175     
Tyr Ala Met Glu Ser Ser Val Leu Arg Val Arg Leu Tyr Asn Asn Lys
            180                 185                 190         
Glu Glu Glu Ile Phe Trp Thr Tyr Asn Ile Ser Thr His Ser Gln Trp
        195                 200                 205             
Val Lys Ala Asp Val Leu Ile Pro Glu Asp Leu Lys Thr Phe Lys Thr
    210                 215                 220                 
Gln Ser Arg Lys Leu Cys Ser Ala Asp Glu Phe Pro Cys Thr Ser Gly
225                 230                 235                 240 
Gln Cys Ile Ala Lys Glu Ser Val Cys Asp Ser Arg Gln Asp Cys Ser
                245                 250                 255     
Asp Glu Ser Asp Glu Asp Pro Ala Thr Cys Ser Lys His Leu Thr Cys
            260                 265                 270         
Asp Phe Glu Ser Gly Phe Cys Gly Trp Glu Pro Phe Leu Thr Glu Asp
        275                 280                 285             
Ser His Trp Lys Leu Met Lys Gly Leu Asn Asn Gly Glu His His Phe
    290                 295                 300                 
Pro Ala Ala Asp His Thr Ala Asn Ile Asn His Val Ser Lys Cys Asp
305                 310                 315                 320 
Phe Glu Ala Asn Ser Cys Asp Trp Phe Glu Ala Ile Ser Gly Asp His
                325                 330                 335     
Phe Asp Trp Ile Arg Ser Ser Gln Ser Glu Leu Ser Ala Asp Phe Glu
            340                 345                 350         
His Gln Ala Pro Pro Arg Asp His Ser Leu Asn Ala Ser Gln Gly His
        355                 360                 365             
Phe Met Phe Ile Leu Lys Lys Ser Ser Ser Leu Trp Gln Val Ala Lys
    370                 375                 380                 
Leu Gln Ser Pro Thr Phe Ser Gln Thr Gly Pro Gly Cys Ile Leu Ser
385                 390                 395                 400 
Phe Trp Phe Tyr Asn Tyr Gly Leu Ser Val Gly Ala Ala Glu Leu Gln
                405                 410                 415     
Leu His Met Glu Asn Ser His Asp Ser Thr Val Ile Trp Arg Val Leu
            420                 425                 430         
Tyr Asn Gln Gly Lys Gln Trp Leu Glu Ala Thr Ile Gln Leu Gly Arg
        435                 440                 445             
Leu Ser Gln Pro Phe His Leu Ser Leu Asp Lys Val Ser Leu Gly Ile
    450                 455                 460                 
Tyr Asp Gly Val Ser Ala Ile Asp Asp Ile Arg Phe Glu Asn Cys Thr
465                 470                 475                 480 
Leu Pro Leu Pro Ala Glu Ser Cys Glu Gly Leu Asp His Phe Trp Cys
                485                 490                 495     
Arg His Thr Arg Ala Cys Ile Glu Lys Leu Arg Leu Cys Asp Leu Val
            500                 505                 510         
Asp Asp Cys Gly Asp Arg Thr Asp Glu Val Asn Cys Ala Pro Glu Leu
        515                 520                 525             
Gln Cys Asn Phe Glu Thr Gly Ile Cys Asn Trp Glu Gln Asp Ala Lys
    530                 535                 540                 
Asp Asp Phe Asp Trp Thr Arg Ser Gln Gly Pro Thr Pro Thr Leu Asn
545                 550                 555                 560 
Thr Gly Pro Met Lys Asp Asn Thr Leu Gly Thr Ala Lys Gly His Tyr
                565                 570                 575     
Leu Tyr Ile Glu Ser Ser Glu Pro Gln Ala Phe Gln Asp Ser Ala Ala
            580                 585                 590         
Leu Leu Ser Pro Ile Leu Asn Ala Thr Asp Thr Lys Gly Cys Thr Phe
        595                 600                 605             
Arg Phe Tyr Tyr His Met Phe Gly Lys Arg Ile Tyr Arg Leu Ala Ile
    610                 615                 620                 
Tyr Gln Arg Ile Trp Ser Asp Ser Arg Gly Gln Leu Leu Trp Gln Ile
625                 630                 635                 640 
Phe Gly Asn Gln Gly Asn Arg Trp Ile Arg Lys His Leu Asn Ile Ser
                645                 650                 655     
Ser Arg Gln Pro Phe Gln Ile Leu Val Glu Ala Ser Val Gly Asp Gly
            660                 665                 670         
Phe Thr Gly Asp Ile Ala Ile Asp Asp Leu Ser Phe Met Asp Cys Thr
        675                 680                 685             
Leu Tyr Pro Gly Asn Leu Pro Ala Asp Leu Pro Thr Pro Pro Glu Thr
    690                 695                 700                 
Ser Val Pro Val Thr Leu Pro Pro His Asn Cys Thr Asp Asn Glu Phe
705                 710                 715                 720 
Ile Cys Arg Ser Asp Gly His Cys Ile Glu Lys Met Gln Lys Cys Asp
                725                 730                 735     
Phe Lys Tyr Asp Cys Pro Asp Lys Ser Asp Glu Ala Ser Cys Val Met
            740                 745                 750         
Glu Val Cys Ser Phe Glu Lys Arg Ser Leu Cys Lys Trp Tyr Gln Pro
        755                 760                 765             
Ile Pro Val His Leu Leu Gln Asp Ser Asn Thr Phe Arg Trp Gly Leu
    770                 775                 780                 
Gly Asn Gly Ile Ser Ile His His Gly Glu Glu Asn His Arg Pro Ser
785                 790                 795                 800 
Val Asp His Thr Gln Asn Thr Thr Asp Gly Trp Tyr Leu Tyr Ala Asp
                805                 810                 815     
Ser Ser Asn Gly Lys Phe Gly Asp Thr Ala Asp Ile Leu Thr Pro Ile
            820                 825                 830         
Ile Ser Leu Thr Gly Pro Lys Cys Thr Leu Val Phe Trp Thr His Met
        835                 840                 845             
Asn Gly Ala Thr Val Gly Ser Leu Gln Val Leu Ile Lys Lys Asp Asn
    850                 855                 860                 
Val Thr Ser Lys Leu Trp Ala Gln Thr Gly Gln Gln Gly Ala Gln Trp
865                 870                 875                 880 
Lys Arg Ala Glu Val Phe Leu Gly Ile Arg Ser His Thr Gln Ile Val
                885                 890                 895     
Phe Arg Ala Lys Arg Gly Ile Ser Tyr Ile Gly Asp Val Ala Val Asp
            900                 905                 910         
Asp Ile Ser Phe Gln Asp Cys Ser Pro Leu Leu Ser Pro Glu Arg Lys
        915                 920                 925             
Cys Thr Asp His Glu Phe Met Cys Ala Asn Lys His Cys Ile Ala Lys
    930                 935                 940                 
Asp Lys Leu Cys Asp Phe Val Asn Asp Cys Ala Asp Asn Ser Asp Glu
945                 950                 955                 960 
Thr Thr Phe Ile Cys Arg Thr Ser Ser Gly Arg Cys Asp Phe Glu Phe
                965                 970                 975     
Asp Leu Cys Ser Trp Lys Gln Glu Lys Asp Glu Asp Phe Asp Trp Asn
            980                 985                 990         
Leu Lys Ala Ser Ser Ile Pro Ala Ala Gly Thr Glu Pro Ala Ala Asp
        995                 1000                1005            
His Thr Leu Gly Asn Ser Ser Gly His Tyr Ile Phe Ile Lys Ser Leu
    1010                1015                1020                
Phe Pro Gln Gln Pro Met Arg Ala Ala Arg Ile Ser Ser Pro Val Ile
1025                1030                1035                1040
Ser Lys Arg Ser Lys Asn Cys Lys Ile Ile Phe His Tyr His Met Tyr
                1045                1050                1055    
Gly Asn Gly Ile Gly Ala Leu Thr Leu Met Gln Val Ser Val Thr Asn
            1060                1065                1070        
Gln Thr Lys Val Leu Leu Asn Leu Thr Val Glu Gln Gly Asn Phe Trp
        1075                1080                1085            
Arg Arg Glu Glu Leu Ser Leu Phe Gly Asp Glu Asp Phe Gln Leu Lys
    1090                1095                1100                
Phe Glu Gly Arg Val Gly Lys Gly Gln Arg Gly Asp Ile Ala Leu Asp
1105                1110                1115                1120
Asp Ile Val Leu Thr Glu Asn Cys Leu Ser Leu His Asp Ser Val Gln
                1125                1130                1135    
Glu Glu Leu Ala Val Pro Leu Pro Thr Gly His Phe Met Tyr Leu Glu
            1140                1145                1150        
Ala Thr Ala Val Gly Leu Arg Gly Asp Lys Ala His Phe Arg Ser Thr
        1155                1160                1165            
Met Trp Arg Glu Ser Ser Ala Ala Cys Thr Met Ser Phe Trp Tyr Phe
    1170                1175                1180                
Val Ser Ala Lys Ala Thr Gly Ser Ile Gln Ile Leu Ile Lys Val Ala
1185                1190                1195                1200
Cys Gly Leu Arg Glu Leu Thr Trp Leu Glu Lys Ala Pro Cys Phe Ser
                1205                1210                1215    
Lys Val Pro Ser Pro Val Ala Glu Met Ile Tyr Gly Val Trp Val Val
            1220                1225                1230        
Ala Asn Val Ile Asp Ile Ser Arg Asn Ser Ile Asn Val Phe Ala Ser
        1235                1240                1245            
Pro Ala His Tyr Thr Ser Thr Thr Gly Ser Cys Asn Phe Glu Thr Ser
    1250                1255                1260                
Ser Gly Asn Trp Thr Thr Ala Cys Ser Leu Thr Gln Asp Ser Glu Asp
1265                1270                1275                1280
Asp Leu Asp Trp Ala Ile Gly Ser Arg Ile Pro Ala Lys Ala Leu Ile
                1285                1290                1295    
Pro Asp Ser Asp His Thr Pro Gly Ser Gly Gln His Phe Leu Tyr Val
            1300                1305                1310        
Asn Ser Ser Gly Ser Lys Glu Gly Ser Val Ala Arg Ile Thr Thr Ser
        1315                1320                1325            
Lys Ser Phe Pro Ala Ser Leu Gly Met Cys Thr Val Arg Phe Trp Phe
    1330                1335                1340                
Tyr Met Ile Asp Pro Arg Ser Met Gly Ile Leu Lys Val Tyr Thr Ile
1345                1350                1355                1360
Glu Glu Ser Gly Leu Asn Ile Leu Val Trp Ser Val Ile Gly Asn Lys
                1365                1370                1375    
Arg Thr Gly Trp Thr Tyr Gly Ser Val Pro Leu Ser Ser Asn Ser Pro
            1380                1385                1390        
Phe Lys Val Ala Phe Glu Ala Asp Leu Asp Gly Asn Glu Asp Ile Phe
        1395                1400                1405            
Ile Ala Leu Asp Asp Ile Ser Phe Thr Pro Glu Cys Val Thr Gly Gly
    1410                1415                1420                
Pro Val Pro Val Gln Pro Ser Pro Cys Glu Ala Asp Gln Phe Ser Cys
1425                1430                1435                1440
Ile Tyr Thr Leu Gln Cys Val Pro Leu Ser Gly Lys Cys Asp Gly His
                1445                1450                1455    
Glu Asp Cys Ile Asp Gly Ser Asp Glu Met Asp Cys Pro Leu Ser Pro
            1460                1465                1470        
Thr Pro Pro Leu Cys Ser Asn Met Glu Phe Pro Cys Ser Thr Asp Glu
        1475                1480                1485            
Cys Ile Pro Ser Leu Leu Leu Cys Asp Gly Val Pro Asp Cys His Phe
    1490                1495                1500                
Asn Glu Asp Glu Leu Ile Cys Ser Asn Lys Ser Cys Ser Asn Gly Ala
1505                1510                1515                1520
Leu Val Cys Ala Ser Ser Asn Ser Cys Ile Pro Ala His Gln Arg Cys
                1525                1530                1535    
Asp Gly Phe Ala Asp Cys Met Asp Phe Gln Leu Asp Glu Ser Ser Cys
            1540                1545                1550        
Ser Gly Thr Pro Phe Pro Phe Arg Tyr Ser Cys Asp Met Asn Gln Gln
        1555                1560                1565            
Leu Asn Leu Gln His Asn Glu Asn Ile Lys Thr
    1570                1575                


<210> 7316
<211> 868
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 176, 559
<223> Xaa = Any Amino Acid

<400> 7316
Met Glu Ser Ser Leu Ala Ile Ser Lys Ala Arg Glu Ser Tyr Glu Asn
 1               5                  10                  15      
Asp Leu Arg Gly Leu Cys Ala Ala Gly Cys Asp Arg Lys Cys Phe Phe
            20                  25                  30          
Ser Phe Pro Val Glu Ala Ser Val Ile Ser Met Leu Leu Thr Val Ile
        35                  40                  45              
Ser Ala Gly Asn Glu Ile Ser Ser Lys Ser Trp Leu Gln Glu Cys Ile
    50                  55                  60                  
Lys Leu Arg Asn Arg Asp Leu Asn Asn Ser Ser Ile Asn Leu Thr Lys
65                  70                  75                  80  
Val Lys Ile Leu Val Asn Asn Arg Pro Pro Thr Gly Val Ser Glu Asn
                85                  90                  95      
Cys Tyr Arg Ala Val Pro Ser Val Cys Leu Lys Gln Gln Ser Leu Ile
            100                 105                 110         
Ala Leu Asn Leu Pro Gln Asp Phe Ser Arg Phe Ser Ser Leu Ser Leu
        115                 120                 125             
Pro Arg His Asn Phe Arg Lys Ser Asn Ile Thr Ala Lys Ser Leu Asp
    130                 135                 140                 
Leu Ser Ser Glu Cys Glu Cys Pro Asn Cys Leu Glu Gly Pro Pro Asn
145                 150                 155                 160 
Glu Ser Asp Trp Asn Thr Cys Ser Asn Glu Ser Gly Asn Gly Ser Xaa
                165                 170                 175     
His Ser Arg Ser Arg Lys Lys Ser Met Leu Ser Ser Ser Met Gln Cys
            180                 185                 190         
Phe Pro Ser Gln Cys Cys Pro Thr Lys Pro Glu Ser Gly Asn Lys Glu
        195                 200                 205             
Asp Ser Ala Val Pro Pro Ser Asp Glu Glu Ser Tyr Val Gly Ser Ser
    210                 215                 220                 
Gln Asn Asn His Leu Ile Leu Ser Leu Glu Asp Met Lys Arg Lys Ile
225                 230                 235                 240 
Lys Pro Leu Arg Glu Trp Thr Ile His Glu Leu Leu Arg Glu Phe Gly
                245                 250                 255     
Asp Asn Gly Lys Phe Gln Pro Asn Ser Met Ser Leu Ser Tyr Phe Arg
            260                 265                 270         
Asp Pro Val Val Met Asn Phe Arg Arg Ala Leu Tyr Tyr Ser Gly Ile
        275                 280                 285             
Trp Val Thr His Ile Arg Gly Tyr Lys Pro Gln Lys His Phe Thr Ala
    290                 295                 300                 
Asn Tyr Phe Lys Arg Asn Pro Gly Cys Leu His Arg Leu Val Pro Trp
305                 310                 315                 320 
Leu Glu Gly Glu Leu Thr Ala Val Tyr Gly Asp Tyr Gly Tyr Thr Val
                325                 330                 335     
Lys Asn Ile Leu Ile Thr Ile Leu His His Met Thr Glu Tyr Asp Leu
            340                 345                 350         
Asp Ser Glu Ser Phe Ile His Leu Leu Glu Pro Tyr Leu Leu Gln His
        355                 360                 365             
Thr His His Phe Leu His Glu Phe Ile Ser Phe Val His Ser Pro Tyr
    370                 375                 380                 
Asn Met Glu Thr Tyr Asp Gln Arg Ala Ile Tyr Gln Cys Ser Ala Ala
385                 390                 395                 400 
Ser Pro Cys Val Asn Lys Lys Pro Leu Val Ser Ala Pro Val Ser Pro
                405                 410                 415     
Leu Pro Lys Asp His Ser Leu Leu Ile Ser Gln His Asn Thr Lys Gln
            420                 425                 430         
Ser Lys Asn Thr Gln Gly Gln Trp Asn Lys Glu Glu Arg Pro Leu Leu
        435                 440                 445             
Gly Leu Lys Gln Phe Pro Asn Gly Asn Ser Ser Leu Lys Lys Ser Glu
    450                 455                 460                 
Ile Pro Pro Val Cys Asp Lys Thr Val Ser Lys Ile Tyr Gly Gly Ile
465                 470                 475                 480 
Lys Asp Lys Ala Glu Ser Gly Asp His Lys Ser Ile Ile Ser Met Asn
                485                 490                 495     
Asn Ile Leu Gln Lys Trp Ala Thr Pro Arg Glu Arg Cys Pro Gly Leu
            500                 505                 510         
Leu Asn Cys Lys Lys Lys Phe Lys Arg Lys Lys Thr Glu Gly Ile Lys
        515                 520                 525             
Leu Phe Pro Asp His Val His Asp Leu Gly Lys Ser Asp Thr Thr Ala
    530                 535                 540                 
His Thr Phe Ser Thr Pro Ala Ile Ser Asn Gln Val Gln Pro Xaa Lys
545                 550                 555                 560 
Tyr Ser Leu Arg Glu Arg Lys Asp Leu Ser Leu Gly Gln Lys Ile Asn
                565                 570                 575     
Phe Gln Lys Lys Glu Glu Asp Asn Asn Lys Tyr Ser Asp Ser Ser Pro
            580                 585                 590         
Lys Thr Phe Gln Arg Leu Ser Arg Glu Arg Ser Leu Lys Arg Cys Lys
        595                 600                 605             
Ser Arg Glu Arg Asp Pro Ser Trp Ser Cys Ile Ser Glu Asn Ala Phe
    610                 615                 620                 
Ser Pro Lys Arg Asp Gly Arg Lys Leu Ser Ser Phe Arg Lys Lys Arg
625                 630                 635                 640 
Met Lys Cys Arg Gln Pro Ser Gln Phe Val Glu Ile Gly Ser His Ser
                645                 650                 655     
Arg Arg Arg Ile Gln Arg Arg Ser Arg Ser Asn Thr His Arg Ser Lys
            660                 665                 670         
Ser Trp Cys Val Gly Ser Arg Lys Arg Ser Val Ser Arg Glu Leu Ser
        675                 680                 685             
Asn Leu Ser Leu Arg Gly Ser His Arg Ser Glu His Phe Thr Gln Asn
    690                 695                 700                 
Ile Cys Cys Glu Pro Ser Lys Asp Lys His Ala His Gly Asn Glu Ser
705                 710                 715                 720 
Asp Cys Gly Arg Pro Ser Ser Thr Thr Val Gln Tyr Val Lys Leu Ser
                725                 730                 735     
Ser Thr Ala Gly Lys Arg Pro Lys Cys Ala Ser Lys Ser Glu Gly Thr
            740                 745                 750         
Ser Gln Ala Gly Arg Arg Cys Asn Ser Pro Thr Cys Leu Gln Leu Gln
        755                 760                 765             
Lys His Arg Ser Pro Ser Lys Gln Glu Ile Lys Gln Glu Thr Thr Phe
    770                 775                 780                 
Pro Arg Ala Arg Arg Thr Arg Ala Val Arg His Arg Lys Thr Lys Cys
785                 790                 795                 800 
His Tyr Ser Asp Ile His Thr Thr Glu Asp Val Ser Asp Glu Leu Gly
                805                 810                 815     
Asn Leu Asp Asp Ile Arg Gln Met Ser Gly Leu Ser Val His Pro Pro
            820                 825                 830         
Ala Gly Gly Lys Ser Thr Lys Asn Ser Ile Gly Ile Phe Arg Ile Phe
        835                 840                 845             
Thr Gly Ser Arg Lys Asn Thr Lys Glu Thr Tyr Tyr Gln Lys His Trp
    850                 855                 860                 
Cys Lys Leu Phe
865             


<210> 7317
<211> 2442
<212> PRT
<213> Homo sapiens

<400> 7317
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys
 1               5                  10                  15      
Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser
            20                  25                  30          
Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly
        35                  40                  45              
Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala
    50                  55                  60                  
Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser
65                  70                  75                  80  
Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln
                85                  90                  95      
Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met
            100                 105                 110         
Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser
        115                 120                 125             
Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr
    130                 135                 140                 
Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly
145                 150                 155                 160 
Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys
                165                 170                 175     
Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn
            180                 185                 190         
Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val
        195                 200                 205             
Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met
    210                 215                 220                 
Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala
225                 230                 235                 240 
Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu
                245                 250                 255     
Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn
            260                 265                 270         
Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met
        275                 280                 285             
Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val
    290                 295                 300                 
Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr
305                 310                 315                 320 
Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro
                325                 330                 335     
Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys
            340                 345                 350         
Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln
        355                 360                 365             
Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His
    370                 375                 380                 
Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala
385                 390                 395                 400 
Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile
                405                 410                 415     
Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro
            420                 425                 430         
Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser
        435                 440                 445             
Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln
    450                 455                 460                 
Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser
465                 470                 475                 480 
Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro
                485                 490                 495     
Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro
            500                 505                 510         
Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro
        515                 520                 525             
Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn
    530                 535                 540                 
Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro
545                 550                 555                 560 
Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr
                565                 570                 575     
Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp
            580                 585                 590         
His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu
        595                 600                 605             
Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg
    610                 615                 620                 
Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met
625                 630                 635                 640 
Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu
                645                 650                 655     
Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg
            660                 665                 670         
Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro
        675                 680                 685             
Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro
    690                 695                 700                 
Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly
705                 710                 715                 720 
Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln
                725                 730                 735     
Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln
            740                 745                 750         
Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg
        755                 760                 765             
Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met
    770                 775                 780                 
Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro
785                 790                 795                 800 
Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln
                805                 810                 815     
Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro
            820                 825                 830         
Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val
        835                 840                 845             
Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala
    850                 855                 860                 
Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro
865                 870                 875                 880 
Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly
                885                 890                 895     
Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr
            900                 905                 910         
Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro
        915                 920                 925             
Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser
    930                 935                 940                 
Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro
945                 950                 955                 960 
Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser
                965                 970                 975     
Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val
            980                 985                 990         
Pro Val Leu Glu Met Lys Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro
        995                 1000                1005            
Asp Pro Gly Glu Ser Lys Gly Glu Pro Arg Ser Glu Met Met Glu Glu
    1010                1015                1020                
Asp Leu Gln Gly Ala Ser Gln Val Lys Glu Glu Thr Asp Ile Ala Glu
1025                1030                1035                1040
Gln Lys Ser Glu Pro Met Glu Val Asp Glu Lys Lys Pro Glu Val Lys
                1045                1050                1055    
Val Glu Val Lys Glu Glu Glu Glu Ser Ser Ser Asn Gly Thr Ala Ser
            1060                1065                1070        
Gln Ser Thr Ser Pro Ser Gln Pro Arg Lys Lys Ile Phe Lys Pro Glu
        1075                1080                1085            
Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln
    1090                1095                1100                
Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu
1105                1110                1115                1120
Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp Leu Ser
                1125                1130                1135    
Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln
            1140                1145                1150        
Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn
        1155                1160                1165            
Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala Glu Val
    1170                1175                1180                
Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys
1185                1190                1195                1200
Gly Arg Lys Tyr Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys
                1205                1210                1215    
Gln Leu Cys Thr Ile Pro Arg Asp Ala Ala Tyr Tyr Ser Tyr Gln Asn
            1220                1225                1230        
Arg Tyr His Phe Cys Glu Lys Cys Phe Thr Glu Ile Gln Gly Glu Asn
        1235                1240                1245            
Val Thr Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Ser Lys
    1250                1255                1260                
Asp Gln Phe Glu Lys Lys Lys Asn Asp Thr Leu Asp Pro Glu Pro Phe
1265                1270                1275                1280
Val Asp Cys Lys Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu
                1285                1290                1295    
His Tyr Asp Ile Ile Trp Pro Ser Gly Phe Val Cys Asp Asn Cys Leu
            1300                1305                1310        
Lys Lys Thr Gly Arg Pro Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg
        1315                1320                1325            
Leu Gln Thr Thr Arg Leu Gly Asn His Leu Glu Asp Arg Val Asn Lys
    1330                1335                1340                
Phe Leu Arg Arg Gln Asn His Pro Glu Ala Gly Glu Val Phe Val Arg
1345                1350                1355                1360
Val Val Ala Ser Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys
                1365                1370                1375    
Ser Arg Phe Val Asp Ser Gly Glu Met Ser Glu Ser Phe Pro Tyr Arg
            1380                1385                1390        
Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Val Cys
        1395                1400                1405            
Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro
    1410                1415                1420                
Asn Thr Arg Arg Val Tyr Ile Ser Tyr Leu Asp Ser Ile His Phe Phe
1425                1430                1435                1440
Arg Pro Arg Cys Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly
                1445                1450                1455    
Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Val Thr Gly His Ile Trp
            1460                1465                1470        
Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro
        1475                1480                1485            
Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys
    1490                1495                1500                
Lys Met Leu Asp Lys Ala Phe Ala Glu Arg Ile Ile His Asp Tyr Lys
1505                1510                1515                1520
Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu
                1525                1530                1535    
Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser
            1540                1545                1550        
Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg Lys Lys Glu Glu Ser
        1555                1560                1565            
Thr Ala Ala Ser Glu Thr Thr Glu Gly Ser Gln Gly Asp Ser Lys Asn
    1570                1575                1580                
Ala Lys Lys Lys Asn Asn Lys Lys Thr Asn Lys Asn Lys Ser Ser Ile
1585                1590                1595                1600
Ser Arg Ala Asn Lys Lys Lys Pro Ser Met Pro Asn Val Ser Asn Asp
                1605                1610                1615    
Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe
            1620                1625                1630        
Phe Val Ile His Leu His Ala Gly Pro Val Ile Asn Thr Leu Pro Pro
        1635                1640                1645            
Ile Val Asp Pro Asp Pro Leu Leu Ser Cys Asp Leu Met Asp Gly Arg
    1650                1655                1660                
Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Trp Glu Phe Ser Ser
1665                1670                1675                1680
Leu Arg Arg Ser Lys Trp Ser Thr Leu Cys Met Leu Val Glu Leu His
                1685                1690                1695    
Thr Gln Gly Gln Asp Arg Phe Val Tyr Thr Cys Asn Glu Cys Lys His
            1700                1705                1710        
His Val Glu Thr Arg Trp His Cys Thr Val Cys Glu Asp Tyr Asp Leu
        1715                1720                1725            
Cys Ile Asn Cys Tyr Asn Thr Lys Ser His Ala His Lys Met Val Lys
    1730                1735                1740                
Trp Gly Leu Gly Leu Asp Asp Glu Gly Ser Ser Gln Gly Glu Pro Gln
1745                1750                1755                1760
Ser Lys Ser Pro Gln Glu Ser Arg Arg Val Ser Ile Gln Arg Cys Ile
                1765                1770                1775    
Gln Ser Leu Val His Ala Cys Gln Cys Arg Asn Ala Asn Cys Ser Leu
            1780                1785                1790        
Pro Ser Cys Gln Lys Met Lys Arg Val Val Gln His Thr Lys Gly Cys
        1795                1800                1805            
Lys Arg Lys Thr Asn Gly Gly Cys Pro Val Cys Lys Gln Leu Ile Ala
    1810                1815                1820                
Leu Cys Cys Tyr His Ala Lys His Cys Gln Glu Asn Lys Cys Pro Val
1825                1830                1835                1840
Pro Phe Cys Leu Asn Ile Lys His Lys Leu Arg Gln Gln Gln Ile Gln
                1845                1850                1855    
His Arg Leu Gln Gln Ala Gln Leu Met Arg Arg Arg Met Ala Thr Met
            1860                1865                1870        
Asn Thr Arg Asn Val Pro Gln Gln Ser Leu Pro Ser Pro Thr Ser Ala
        1875                1880                1885            
Pro Pro Gly Thr Pro Thr Gln Gln Pro Ser Thr Pro Gln Thr Pro Gln
    1890                1895                1900                
Pro Pro Ala Gln Pro Gln Pro Ser Pro Val Ser Met Ser Pro Ala Gly
1905                1910                1915                1920
Phe Pro Ser Val Ala Arg Thr Gln Pro Pro Thr Thr Val Ser Thr Gly
                1925                1930                1935    
Lys Pro Thr Ser Gln Val Pro Ala Pro Pro Pro Pro Ala Gln Pro Pro
            1940                1945                1950        
Pro Ala Ala Val Glu Ala Ala Arg Gln Ile Glu Arg Glu Ala Gln Gln
        1955                1960                1965            
Gln Gln His Leu Tyr Arg Val Asn Ile Asn Asn Ser Met Pro Pro Gly
    1970                1975                1980                
Arg Thr Gly Met Gly Thr Pro Gly Ser Gln Met Ala Pro Val Ser Leu
1985                1990                1995                2000
Asn Val Pro Arg Pro Asn Gln Val Ser Gly Pro Val Met Pro Ser Met
                2005                2010                2015    
Pro Pro Gly Gln Trp Gln Gln Ala Pro Leu Pro Gln Gln Gln Pro Met
            2020                2025                2030        
Pro Gly Leu Pro Arg Pro Val Ile Ser Met Gln Ala Gln Ala Ala Val
        2035                2040                2045            
Ala Gly Pro Arg Met Pro Ser Val Gln Pro Pro Arg Ser Ile Ser Pro
    2050                2055                2060                
Ser Ala Leu Gln Asp Leu Leu Arg Thr Leu Lys Ser Pro Ser Ser Pro
2065                2070                2075                2080
Gln Gln Gln Gln Gln Val Leu Asn Ile Leu Lys Ser Asn Pro Gln Leu
                2085                2090                2095    
Met Ala Ala Phe Ile Lys Gln Arg Thr Ala Lys Tyr Val Ala Asn Gln
            2100                2105                2110        
Pro Gly Met Gln Pro Gln Pro Gly Leu Gln Ser Gln Pro Gly Met Gln
        2115                2120                2125            
Pro Gln Pro Gly Met His Gln Gln Pro Ser Leu Gln Asn Leu Asn Ala
    2130                2135                2140                
Met Gln Ala Gly Val Pro Arg Pro Gly Val Pro Pro Gln Gln Gln Ala
2145                2150                2155                2160
Met Gly Gly Leu Asn Pro Gln Gly Gln Ala Leu Asn Ile Met Asn Pro
                2165                2170                2175    
Gly His Asn Pro Asn Met Ala Ser Met Asn Pro Gln Tyr Arg Glu Met
            2180                2185                2190        
Leu Arg Arg Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        2195                2200                2205            
Gln Gln Gln Gln Gln Gln Gln Gln Gly Ser Ala Gly Met Ala Gly Gly
    2210                2215                2220                
Met Ala Gly His Gly Gln Phe Gln Gln Pro Gln Gly Pro Gly Gly Tyr
2225                2230                2235                2240
Pro Pro Ala Met Gln Gln Gln Gln Arg Met Gln Gln His Leu Pro Leu
                2245                2250                2255    
Gln Gly Ser Ser Met Gly Gln Met Ala Ala Gln Met Gly Gln Leu Gly
            2260                2265                2270        
Gln Met Gly Gln Pro Gly Leu Gly Ala Asp Ser Thr Pro Asn Ile Gln
        2275                2280                2285            
Gln Ala Leu Gln Gln Arg Ile Leu Gln Gln Gln Gln Met Lys Gln Gln
    2290                2295                2300                
Ile Gly Ser Pro Gly Gln Pro Asn Pro Met Ser Pro Gln Gln His Met
2305                2310                2315                2320
Leu Ser Gly Gln Pro Gln Ala Ser His Leu Pro Gly Gln Gln Ile Ala
                2325                2330                2335    
Thr Ser Leu Ser Asn Gln Val Arg Ser Pro Ala Pro Val Gln Ser Pro
            2340                2345                2350        
Arg Pro Gln Ser Gln Pro Pro His Ser Ser Pro Ser Pro Arg Ile Gln
        2355                2360                2365            
Pro Gln Pro Ser Pro His His Val Ser Pro Gln Thr Gly Ser Pro His
    2370                2375                2380                
Pro Gly Leu Ala Val Thr Met Ala Ser Ser Ile Asp Gln Gly His Leu
2385                2390                2395                2400
Gly Asn Pro Glu Gln Ser Ala Met Leu Pro Gln Leu Asn Thr Pro Ser
                2405                2410                2415    
Arg Ser Ala Leu Ser Ser Glu Leu Ser Leu Val Gly Asp Thr Thr Gly
            2420                2425                2430        
Asp Thr Leu Glu Lys Phe Val Glu Gly Leu
        2435                2440        


<210> 7318
<211> 1403
<212> PRT
<213> Homo sapiens

<400> 7318
Ala Thr Gln Gly Arg Leu Arg Arg Arg Pro Glu Gly Ala Arg Val Pro
 1               5                  10                  15      
Ser Ala Arg Arg Gly Arg Pro Arg Ala Arg Trp Arg Ala Pro Gln Asn
            20                  25                  30          
Asn Pro Glu Val Asp Ser Ile Met Ala Glu Leu Lys Val Glu Ala Pro
        35                  40                  45              
Ala Ser Val Asp Trp Gln Lys Arg Cys Leu Thr Leu Glu Thr Gln Leu
    50                  55                  60                  
Phe Arg Phe Arg Leu Gln Ala Ser Lys Ile Arg Glu Leu Leu Ala Asp
65                  70                  75                  80  
Lys Met Gln Glu Leu Glu Gln Arg Leu Leu Glu Ala Glu Gln Arg Ala
                85                  90                  95      
Glu Asn Ala Glu Thr Gln Val Gly Val Met Glu Glu Lys Val Lys Leu
            100                 105                 110         
Ser Asn Leu Lys Asn Val Asp Ser Glu Gly Ser Leu His Arg Lys Tyr
        115                 120                 125             
Gln Glu Leu Leu Lys Ala Ile Lys Gly Lys Asp Glu Leu Ile Ser Gln
    130                 135                 140                 
Leu Glu Ala Gln Leu Glu Lys Gln Lys Gln Met Arg Ala Glu Glu Ala
145                 150                 155                 160 
Lys Thr Val Gln Glu Lys Ala Ala Lys Ile Lys Glu Trp Val Thr Leu
                165                 170                 175     
Lys Leu Ala Lys Leu Glu Met Glu Asn Gln His Leu Lys Ser His Asn
            180                 185                 190         
Gln Arg Leu Val Glu Gln Val Gly Ser Leu Gln Asp Ala Leu Glu Ala
        195                 200                 205             
Ile Gln Ile Ala Pro Ser Arg Lys Leu Leu Val Pro Pro Tyr Gly Ala
    210                 215                 220                 
Ala Glu Gln Asp Ser Val Pro Ser Glu Pro Gly Ile Gln Pro Met Gly
225                 230                 235                 240 
Gln Asp Ser Gly Ser Gln Ala Gln Gly Leu Lys Ala Ala Val Leu Ala
                245                 250                 255     
Pro Ser Pro Gly Ala Leu Gln Ser Lys Asp Ser Val Ser Glu Ala Ala
            260                 265                 270         
Ser Pro Leu Glu Asp Ser Ser Ser Ser Thr Val His Ser Gly Glu Thr
        275                 280                 285             
Val Glu Ala Lys Pro Leu Gln Pro His Leu Gly Arg Glu Ser Pro Pro
    290                 295                 300                 
His Gln Pro Cys Met Lys Leu Leu Thr Phe Arg Cys Ser Ser Ala Ser
305                 310                 315                 320 
Trp Gly Glu Gly Leu Val Thr Ala Gln Arg Gly Met Leu Pro Gly Thr
                325                 330                 335     
Lys Thr Ser Ala Arg Glu Gly Gly Pro Gly Ser Ser Leu Thr Leu Pro
            340                 345                 350         
Lys Val Arg Ala Pro Gly Thr Pro Arg Asp Ser Ile Gln Leu Ala Lys
        355                 360                 365             
Arg His His Ser Gln Pro Gln Val Gly His Gly His Phe Gly Arg Val
    370                 375                 380                 
Val Asn Ile Glu Thr Glu Ala Phe Ser Ala Leu His Pro Ser Gly Leu
385                 390                 395                 400 
Pro Glu Leu Glu Ser Arg Ala Arg Ser Arg Glu Glu Pro Glu Lys Met
                405                 410                 415     
Glu Met Glu Glu Pro Pro Pro Ala Gly Lys Asn Glu Glu Arg Glu Ser
            420                 425                 430         
Pro Lys Ala Leu Gly Ala Glu Leu Glu Glu Val Glu Leu Gly Asn Lys
        435                 440                 445             
Pro Pro Thr Pro Pro Leu His Gln Phe Ser Ser Trp Glu Ser Arg Ile
    450                 455                 460                 
Tyr Ala Val Ala Thr Ser Gly Met Arg Leu Ser Asp Met Ser Pro Arg
465                 470                 475                 480 
Ser Asn Thr Ala Cys Cys Ala Ser Ser Pro Pro Ala Leu Val Ser Pro
                485                 490                 495     
Gly Ser Phe Ser Gly Leu Val Tyr Lys Asn Val Thr Val Pro Val Tyr
            500                 505                 510         
Thr Ala Leu Lys Gly Arg Ala Thr Gln Ile Ser Asn Met Pro Phe Met
        515                 520                 525             
Asp Glu Ser Ser Gly Ser Asp Asp Asp Cys Ser Ser Gln Ala Ser Phe
    530                 535                 540                 
Arg Ile Ser Val Pro Ser Ser Glu Ser Arg Lys Thr Ser Gly Leu Gly
545                 550                 555                 560 
Ser Pro Arg Ala Ile Lys Arg Gly Val Ser Met Ser Ser Leu Ser Ser
                565                 570                 575     
Glu Gly Asp Tyr Ala Ile Pro Pro Asp Ala Cys Ser Leu Asp Ser Asp
            580                 585                 590         
Tyr Ser Glu Pro Glu His Lys Leu Gln Arg Thr Ser Ser Tyr Ser Thr
        595                 600                 605             
Asp Gly Leu Gly Leu Gly Gly Glu Ser Leu Glu Lys Ser Gly Tyr Leu
    610                 615                 620                 
Leu Lys Met Gly Ser Gln Val Lys Thr Trp Lys Arg Arg Trp Phe Val
625                 630                 635                 640 
Leu Arg Gln Gly Gln Ile Met Tyr Tyr Lys Ser Pro Ser Asp Val Ile
                645                 650                 655     
Arg Lys Pro Gln Gly Gln Val Asp Leu Asn Ser Arg Cys Gln Ile Val
            660                 665                 670         
Arg Gly Glu Gly Ser Gln Thr Phe Gln Leu Ile Ser Glu Lys Lys Thr
        675                 680                 685             
Tyr Tyr Leu Thr Ala Asp Ser Pro Ser Leu Leu Glu Glu Trp Ile Arg
    690                 695                 700                 
Val Leu Gln Ser Leu Leu Lys Val Gln Ala Thr Gly Pro Pro Ala Leu
705                 710                 715                 720 
Leu Arg Gly Gly Thr Lys Pro Thr Val Lys Gly Trp Leu Thr Lys Val
                725                 730                 735     
Lys His Gly His Ser Lys Val Val Trp Cys Ala Leu Val Gly Lys Ile
            740                 745                 750         
Phe Tyr Tyr Tyr Arg Ser His Glu Asp Lys Arg Pro Leu Gly Cys Leu
        755                 760                 765             
Pro Val Arg Asp Ala His Ile Glu Glu Val Asp Arg Ser Cys Asp Ser
    770                 775                 780                 
Asp Glu Asp Tyr Glu Ala Gly Gly Thr Arg Arg Leu Leu Ser Ser His
785                 790                 795                 800 
Cys Thr Leu Val Ile His Pro Thr Glu His Ser Pro Thr Tyr Leu Leu
                805                 810                 815     
Ile Gly Thr Lys His Glu Lys Asp Thr Trp Leu Tyr His Leu Thr Val
            820                 825                 830         
Ala Ala Gly Gly Ser Ser Ala Lys Val Gly Thr Ala Tyr Glu Gln Leu
        835                 840                 845             
Ile Gly Lys Leu Met Asp Gly Glu Gly Asp Pro Asp Ser Pro Leu Trp
    850                 855                 860                 
Arg His Pro Met Leu Cys Tyr Ser Lys Asp Gly Leu Tyr Ala Ser Leu
865                 870                 875                 880 
Thr Thr Leu Pro Ser Glu Ala Leu Gln Thr Glu Ala Leu Lys Leu Phe
                885                 890                 895     
Lys Ser Cys Gln Leu Phe Ile Asn Val Pro Val Glu Ala Ala Ser Val
            900                 905                 910         
Asp Tyr His Val Ser Leu Ala Gln Thr Ala Leu Gln Val Cys Leu Val
        915                 920                 925             
His Pro Glu Leu Gln Ser Glu Ile Tyr Cys Gln Leu Met Lys Gln Thr
    930                 935                 940                 
Ser Cys Arg Pro Pro Gln Lys Tyr Ser Leu Met Gln Cys Trp Gln Leu
945                 950                 955                 960 
Leu Ala Leu Cys Ala Pro Leu Phe Leu Pro Gln His His Phe Leu Trp
                965                 970                 975     
Tyr Val Lys Gln Gln Leu Gln Arg His Ala Asp Pro Arg Ser Glu Thr
            980                 985                 990         
Gly Gln Tyr Ala Thr Tyr Cys Gln Arg Ala Val Glu Arg Thr Leu Arg
        995                 1000                1005            
Thr Gly Glu Arg Glu Ala Arg Pro Ser Arg Met Glu Val Val Ser Ile
    1010                1015                1020                
Leu Leu Arg Asn Pro Phe His His Ser Leu Pro Phe Ser Ile Pro Val
1025                1030                1035                1040
His Phe Thr Asn Gly Thr Tyr His Val Val Gly Phe Asp Gly Ser Ser
                1045                1050                1055    
Thr Val Asp Glu Phe Leu Gln Arg Leu Asn Gln Glu Ile Gly Met Arg
            1060                1065                1070        
Lys Pro Ser His Ser Gly Phe Ala Leu Phe Thr Asp Asp Pro Ser Gly
        1075                1080                1085            
Arg Asp Leu Glu His Cys Leu Gln Gly Ser Val Lys Ile Cys Asp Ala
    1090                1095                1100                
Ile Ser Lys Trp Glu Gln Ala Met Lys Glu Leu His Pro Gly Lys Ser
1105                1110                1115                1120
Glu Gly Gly Thr Arg Val Val Lys Leu Met Tyr Lys Asn Arg Leu Tyr
                1125                1130                1135    
Phe Arg Ser Gln Val Lys Gly Glu Thr Asp Arg Glu Arg Leu Leu Leu
            1140                1145                1150        
Ala Ser Gln Thr Ser Arg Glu Ile Val Ala Gly Arg Phe Pro Ile Asn
        1155                1160                1165            
Lys Glu Leu Ala Leu Glu Met Ala Ala Leu Met Ala Gln Val Glu Tyr
    1170                1175                1180                
Gly Asp Leu Glu Lys Pro Ala Leu Pro Gly Pro Gly Gly Thr Ser Pro
1185                1190                1195                1200
Ala Lys Ala Gln His Leu Leu Gln Gln Val Leu Asp Arg Phe His Pro
                1205                1210                1215    
Arg Arg Tyr Arg His Gly Ala Pro Ala Glu Gln Leu Arg His Leu Ala
            1220                1225                1230        
Asp Met Leu Thr Thr Lys Trp Ala Thr Leu Gln Gly Cys Ser Pro Pro
        1235                1240                1245            
Glu Cys Ile Arg Ile Tyr Leu Thr Val Ala Arg Lys Trp Pro Phe Phe
    1250                1255                1260                
Gly Ala Lys Leu Phe Ala Ala Gln Pro Ala Gln Leu Ser Ser Lys Glu
1265                1270                1275                1280
Asn Ala Leu Val Trp Ile Ala Val Asn Glu Asp Gly Val Ser Ile Leu
                1285                1290                1295    
Asp His Asn Thr Met Gln Val His Ile Thr Tyr Pro Tyr Ser Ser Val
            1300                1305                1310        
Thr Thr Phe Gly Gly Cys Arg Asp Asp Phe Met Leu Val Ile Arg Ser
        1315                1320                1325            
Ile Pro Asp Lys Ser Ser Gly Lys Ser His Ile Glu Lys Leu Ile Phe
    1330                1335                1340                
Arg Met Ala Ala Pro Lys Ile Ala Glu Ala Thr Phe Ile Met Ala Ser
1345                1350                1355                1360
Tyr Met Asn His Cys Thr Thr Thr Val Asn Pro Pro Thr Asn Pro Pro
                1365                1370                1375    
Gly Ala Cys Gln Leu Trp Glu Leu Asp Gly Arg Gln Phe Phe Ser Ser
            1380                1385                1390        
Val Ser Cys Ala Thr Lys Gly Pro Thr Leu Leu
        1395                1400            


<210> 7319
<211> 223
<212> PRT
<213> Homo sapiens

<400> 7319
Met Pro Leu Gly Ala Ser Ser Leu Thr Tyr Gln Pro Ser Tyr Gly Gln
 1               5                  10                  15      
Gly Leu Arg Thr Ser Ser Leu Ser His Ser Ala Cys Pro Thr Pro Asn
            20                  25                  30          
Pro Leu Ser Arg His Ser Pro Ala Pro Phe Ser Lys Ser Ser Thr Phe
        35                  40                  45              
Tyr Arg Asn Ser Pro Ala Arg Glu Leu His Leu Pro Ile Arg Asp Gly
    50                  55                  60                  
Asn Thr Leu Glu Met His Gly Asp Thr Cys Gln Pro Gly Ile Phe Asn
65                  70                  75                  80  
Tyr Ala Thr Arg Leu Gly Arg Arg Ser Lys Ser Pro Gln Ala Met Ala
                85                  90                  95      
Ser His Gly Ser Arg Pro Gly Ser Arg Leu Lys Gln Pro Ile Gly Gln
            100                 105                 110         
Ile Pro Leu Glu Ser Ser Pro Pro Val Gly Leu Ser Ile Glu Glu Val
        115                 120                 125             
Glu Arg Leu Asn Thr Pro Arg Pro Arg Asn Pro Ser Ile Cys Ser Ala
    130                 135                 140                 
Asp His Gly Arg Ser Ser Ser Glu Glu Asp Cys Arg Arg Pro Leu Ser
145                 150                 155                 160 
Arg Thr Arg Asn Pro Ala Asp Gly Ile Pro Ala Pro Glu Ser Ser Ser
                165                 170                 175     
Asp Ser Asp Ser His Glu Ser Ser Leu Ala Gln Lys Trp Asn Met Thr
            180                 185                 190         
Gly Arg Ser Gln Trp Tyr Ile Leu Pro Glu Cys Pro Asn Tyr Leu Lys
        195                 200                 205             
Ser Met Asn Leu Met Gln Met Met Lys Ile Ile Met Glu Pro Asp
    210                 215                 220             


<210> 7320
<211> 288
<212> PRT
<213> Homo sapiens

<400> 7320
Met Ile Leu Leu Gln His Ala Val Leu Pro Pro Pro Lys Gln Pro Ser
 1               5                  10                  15      
Pro Ser Pro Pro Met Ser Val Ala Thr Arg Ser Thr Gly Thr Leu Gln
            20                  25                  30          
Leu Pro Pro Gln Lys Pro Phe Gly Gln Glu Ala Ser Leu Pro Leu Ala
        35                  40                  45              
Gly Glu Glu Glu Leu Ser Lys Gly Gly Glu Gln Asp Cys Ala Leu Glu
    50                  55                  60                  
Glu Leu Cys Lys Pro Leu Tyr Cys Lys Leu Cys Asn Val Thr Leu Asn
65                  70                  75                  80  
Ser Ala Gln Gln Ala Gln Ala His Tyr Gln Gly Lys Asn His Gly Lys
                85                  90                  95      
Lys Leu Arg Asn Tyr Tyr Ala Ala Asn Ser Cys Pro Pro Pro Ala Arg
            100                 105                 110         
Met Ser Asn Val Val Glu Pro Ala Ala Thr Pro Val Val Pro Val Pro
        115                 120                 125             
Pro Gln Met Gly Ser Phe Lys Pro Gly Gly Arg Val Ile Leu Ala Thr
    130                 135                 140                 
Glu Asn Asp Tyr Cys Lys Leu Cys Asp Ala Ser Phe Ser Ser Pro Ala
145                 150                 155                 160 
Val Ala Gln Ala His Tyr Gln Gly Lys Asn His Ala Lys Arg Leu Arg
                165                 170                 175     
Leu Ala Glu Ala Gln Ser Asn Ser Phe Ser Glu Ser Ser Glu Leu Gly
            180                 185                 190         
Gln Arg Arg Ala Arg Lys Glu Gly Asn Glu Phe Lys Met Met Pro Asn
        195                 200                 205             
Arg Arg Asn Met Tyr Thr Val Gln Asn Asn Ser Gly Pro Tyr Phe Asn
    210                 215                 220                 
Pro Arg Ser Arg Gln Arg Ile Pro Arg Asp Leu Ala Met Cys Val Thr
225                 230                 235                 240 
Pro Ser Gly Gln Phe Tyr Cys Ser Met Cys Asn Val Gly Ala Gly Glu
                245                 250                 255     
Glu Met Glu Phe Arg Gln His Leu Glu Ser Lys Gln His Lys Ser Lys
            260                 265                 270         
Val Ser Glu Gln Arg Tyr Arg Asn Glu Met Glu Asn Leu Gly Tyr Val
        275                 280                 285             


<210> 7321
<211> 998
<212> PRT
<213> Homo sapiens

<400> 7321
Met Ala Ala Val Lys Glu Pro Leu Glu Phe His Ala Lys Arg Pro Trp
 1               5                  10                  15      
Arg Pro Glu Glu Ala Val Glu Asp Pro Asp Glu Glu Asp Glu Asp Asn
            20                  25                  30          
Thr Ser Glu Ala Glu Asn Gly Phe Ser Leu Glu Glu Val Leu Arg Leu
        35                  40                  45              
Gly Gly Thr Lys Gln Asp Tyr Leu Met Leu Ala Thr Leu Asp Glu Asn
    50                  55                  60                  
Glu Glu Val Ile Asp Gly Gly Lys Lys Gly Ala Ile Asp Asp Leu Gln
65                  70                  75                  80  
Gln Gly Glu Leu Glu Ala Phe Ile Gln Asn Leu Asn Leu Ala Lys Tyr
                85                  90                  95      
Thr Lys Ala Ser Leu Ile Glu Glu Asp Glu Pro Ala Glu Lys Glu Asn
            100                 105                 110         
Ser Ser Lys Lys Glu Val Lys Ile Pro Lys Ile Asn Asn Lys Asn Thr
        115                 120                 125             
Ala Glu Ser Gln Arg Thr Ser Val Asn Lys Val Lys Asn Lys Asn Arg
    130                 135                 140                 
Pro Glu Pro His Ser Asp Glu Asn Gly Ser Thr Thr Pro Lys Val Lys
145                 150                 155                 160 
Lys Asp Lys Gln Asn Ile Phe Glu Phe Phe Glu Arg Gln Thr Leu Leu
                165                 170                 175     
Leu Arg Pro Gly Gly Lys Trp Tyr Asp Leu Glu Tyr Ser Asn Glu Tyr
            180                 185                 190         
Ser Leu Lys Pro Gln Pro Gln Asp Val Val Ser Lys Tyr Lys Thr Leu
        195                 200                 205             
Ala Gln Lys Leu Tyr Gln His Glu Ile Asn Leu Phe Lys Ser Lys Thr
    210                 215                 220                 
Asn Ser Gln Lys Gly Ala Ser Ser Thr Trp Met Lys Ala Ile Val Ser
225                 230                 235                 240 
Ser Gly Thr Leu Gly Asp Arg Met Ala Ala Met Ile Leu Leu Ile Gln
                245                 250                 255     
Asp Asp Ala Val His Thr Leu Gln Phe Val Glu Thr Leu Val Asn Leu
            260                 265                 270         
Val Lys Lys Lys Gly Ser Lys Gln Gln Cys Leu Met Ala Leu Asp Thr
        275                 280                 285             
Phe Lys Glu Leu Leu Ile Thr Asp Leu Leu Pro Asp Asn Arg Lys Leu
    290                 295                 300                 
Arg Ile Phe Ser Gln Arg Pro Phe Asp Lys Leu Glu Gln Leu Ser Ser
305                 310                 315                 320 
Gly Asn Lys Asp Ser Arg Asp Arg Arg Leu Ile Leu Trp Tyr Phe Glu
                325                 330                 335     
His Gln Leu Lys His Leu Val Ala Glu Phe Val Gln Val Leu Glu Thr
            340                 345                 350         
Leu Ser His Asp Thr Leu Val Thr Thr Lys Thr Arg Ala Leu Thr Val
        355                 360                 365             
Ala His Glu Leu Leu Cys Asn Lys Pro Glu Glu Glu Lys Ala Leu Leu
    370                 375                 380                 
Val Gln Val Val Asn Lys Leu Gly Asp Pro Gln Asn Arg Ile Ala Thr
385                 390                 395                 400 
Lys Ala Ser His Leu Leu Glu Thr Leu Leu Cys Lys His Pro Asn Met
                405                 410                 415     
Lys Gly Val Val Ser Gly Glu Val Glu Arg Leu Leu Phe Arg Ser Asn
            420                 425                 430         
Ile Ser Ser Lys Ala Gln Tyr Tyr Ala Ile Cys Phe Leu Asn Gln Met
        435                 440                 445             
Ala Leu Ser His Glu Glu Ser Glu Leu Ala Asn Lys Leu Ile Thr Val
    450                 455                 460                 
Tyr Phe Cys Phe Phe Arg Thr Cys Val Lys Lys Lys Asp Val Glu Ser
465                 470                 475                 480 
Lys Met Leu Ser Ala Leu Leu Thr Gly Val Asn Arg Ala Tyr Pro Tyr
                485                 490                 495     
Ser Gln Thr Gly Asp Asp Lys Val Arg Glu Gln Ile Asp Thr Leu Phe
            500                 505                 510         
Lys Val Leu His Ile Val Asn Phe Asn Thr Ser Val Gln Ala Leu Met
        515                 520                 525             
Leu Leu Phe Gln Val Met Asn Ser Gln Gln Thr Ile Ser Asp Arg Tyr
    530                 535                 540                 
Tyr Thr Ala Leu Tyr Arg Lys Met Leu Asp Pro Gly Leu Met Thr Cys
545                 550                 555                 560 
Ser Lys Gln Ala Met Phe Leu Asn Leu Val Tyr Lys Ser Leu Lys Ala
                565                 570                 575     
Asp Ile Val Leu Arg Arg Val Lys Ala Phe Val Lys Gly Leu Leu Gln
            580                 585                 590         
Val Thr Cys Gln Gln Met Pro Pro Phe Ile Cys Gly Ala Leu Tyr Leu
        595                 600                 605             
Val Ser Glu Ile Leu Lys Ala Lys Pro Gly Leu Arg Ser Gln Leu Asp
    610                 615                 620                 
Asp His Pro Glu Ser Asp Asp Glu Glu Asn Phe Ile Asp Ala Asn Asp
625                 630                 635                 640 
Asp Glu Asp Met Glu Lys Phe Thr Asp Ala Asp Lys Glu Thr Glu Ile
                645                 650                 655     
Val Lys Lys Leu Glu Thr Glu Glu Thr Val Pro Glu Thr Asp Val Glu
            660                 665                 670         
Thr Lys Lys Pro Glu Val Ala Ser Trp Val His Phe Asp Asn Leu Lys
        675                 680                 685             
Gly Gly Lys Gln Leu Asn Lys Tyr Asp Pro Phe Ser Arg Asn Pro Leu
    690                 695                 700                 
Phe Cys Gly Ala Glu Asn Thr Ser Leu Trp Glu Leu Lys Lys Leu Ser
705                 710                 715                 720 
Val His Phe His Pro Ser Val Ala Leu Phe Ala Lys Thr Ile Leu Gln
                725                 730                 735     
Gly Asn Tyr Ile Gln Tyr Ser Gly Asp Pro Leu Gln Asp Phe Thr Leu
            740                 745                 750         
Met Arg Phe Leu Asp Arg Phe Val Tyr Arg Asn Pro Lys Pro His Lys
        755                 760                 765             
Gly Lys Glu Asn Thr Asp Ser Val Val Met Gln Pro Lys Arg Lys His
    770                 775                 780                 
Phe Ile Lys Asp Ile Arg His Leu Pro Val Asn Ser Lys Glu Phe Leu
785                 790                 795                 800 
Ala Lys Glu Glu Ser Gln Ile Pro Val Asp Glu Val Phe Phe His Arg
                805                 810                 815     
Tyr Tyr Lys Lys Val Ala Val Lys Glu Lys Gln Lys Arg Asp Ala Asp
            820                 825                 830         
Glu Glu Ser Ile Glu Asp Val Asp Asp Glu Glu Phe Glu Glu Leu Ile
        835                 840                 845             
Asp Thr Phe Glu Asp Asp Asn Cys Phe Ser Ser Gly Lys Asp Asp Met
    850                 855                 860                 
Asp Phe Ala Gly Asn Val Lys Lys Arg Thr Lys Gly Ala Lys Asp Asn
865                 870                 875                 880 
Thr Leu Asp Glu Asp Ser Glu Gly Ser Asp Asp Glu Leu Gly Asn Leu
                885                 890                 895     
Asp Asp Asp Glu Val Ser Leu Gly Ser Met Asp Asp Glu Glu Phe Ala
            900                 905                 910         
Glu Val Asp Glu Asp Gly Gly Thr Phe Met Asp Val Leu Asp Asp Glu
        915                 920                 925             
Ser Glu Ser Val Pro Glu Leu Glu Val His Ser Lys Val Ser Thr Lys
    930                 935                 940                 
Lys Ser Lys Arg Lys Gly Thr Asp Asp Phe Asp Phe Ala Gly Ser Phe
945                 950                 955                 960 
Gln Gly Pro Arg Lys Lys Lys Arg Asn Leu Asn Asp Ser Ser Leu Phe
                965                 970                 975     
Val Ser Ala Glu Glu Phe Gly His Leu Leu Asp Glu Asn Met Gly Ser
            980                 985                 990         
Lys Phe Asp Asn Ile Ala
        995             


<210> 7322
<211> 854
<212> PRT
<213> Homo sapiens

<400> 7322
Met Met Ala Tyr Ser Asp Thr Thr Met Met Ser Asp Asp Ile Asp Trp
 1               5                  10                  15      
Leu Arg Ser His Arg Gly Val Cys Lys Val Asp Leu Tyr Asn Pro Glu
            20                  25                  30          
Gly Gln Gln Asp Gln Asp Arg Lys Val Ile Cys Phe Val Asp Val Ser
        35                  40                  45              
Thr Leu Asn Val Glu Asp Lys Asp Tyr Lys Asp Ala Ala Ser Ser Ser
    50                  55                  60                  
Ser Glu Gly Asn Leu Asn Leu Gly Ser Leu Glu Glu Lys Glu Ile Ile
65                  70                  75                  80  
Val Ile Lys Asp Thr Glu Lys Lys Asp Gln Ser Lys Thr Glu Gly Ser
                85                  90                  95      
Val Cys Leu Phe Lys Gln Ala Pro Ser Asp Pro Val Ser Val Leu Asn
            100                 105                 110         
Trp Leu Leu Ser Asp Leu Gln Lys Tyr Ala Leu Gly Phe Gln His Ala
        115                 120                 125             
Leu Ser Pro Ser Thr Ser Thr Cys Lys His Lys Val Gly Asp Thr Glu
    130                 135                 140                 
Gly Glu Tyr His Arg Ala Ser Ser Glu Asn Cys Tyr Ser Val Tyr Ala
145                 150                 155                 160 
Asp Gln Val Asn Ile Asp Tyr Leu Met Asn Arg Pro Gln Asn Leu Arg
                165                 170                 175     
Leu Glu Met Thr Ala Ala Lys Asn Thr Asn Asn Asn Gln Ser Pro Ser
            180                 185                 190         
Ala Pro Pro Ala Lys Pro Pro Ser Thr Gln Arg Ala Val Ile Ser Pro
        195                 200                 205             
Asp Gly Glu Cys Ser Ile Asp Asp Leu Ser Phe Tyr Val Asn Arg Leu
    210                 215                 220                 
Ser Ser Leu Val Ile Gln Met Ala His Lys Glu Ile Lys Glu Lys Leu
225                 230                 235                 240 
Glu Gly Lys Ser Lys Cys Leu His His Ser Ile Cys Pro Ser Pro Gly
                245                 250                 255     
Asn Lys Glu Arg Ile Ser Pro Arg Thr Pro Ala Ser Lys Ile Ala Ser
            260                 265                 270         
Glu Met Ala Tyr Glu Ala Val Glu Leu Thr Ala Ala Glu Met Arg Gly
        275                 280                 285             
Thr Gly Glu Glu Ser Arg Glu Gly Gly Gln Lys Ser Phe Leu Tyr Ser
    290                 295                 300                 
Glu Leu Ser Asn Lys Ser Lys Ser Gly Asp Lys Gln Met Ser Gln Arg
305                 310                 315                 320 
Glu Ser Lys Glu Phe Ala Asp Ser Ile Ser Lys Gly Leu Met Val Tyr
                325                 330                 335     
Ala Asn Gln Val Ala Ser Asp Met Met Val Ser Leu Met Lys Thr Leu
            340                 345                 350         
Lys Val His Ser Ser Gly Lys Pro Ile Pro Ala Ser Val Val Leu Lys
        355                 360                 365             
Arg Val Leu Leu Arg His Thr Lys Glu Ile Val Ser Asp Leu Ile Asp
    370                 375                 380                 
Ser Cys Met Lys Asn Leu His Asn Ile Thr Gly Val Leu Met Thr Asp
385                 390                 395                 400 
Ser Asp Phe Val Ser Ala Val Lys Arg Asn Leu Phe Asn Gln Trp Lys
                405                 410                 415     
Gln Asn Ala Thr Asp Ile Met Glu Ala Met Leu Lys Arg Leu Val Ser
            420                 425                 430         
Ala Leu Ile Gly Glu Glu Lys Glu Thr Lys Ser Gln Ser Leu Ser Tyr
        435                 440                 445             
Ala Ser Leu Lys Ala Gly Ser His Asp Pro Lys Cys Arg Asn Gln Ser
    450                 455                 460                 
Leu Glu Phe Ser Thr Met Lys Ala Glu Met Lys Glu Arg Asp Lys Gly
465                 470                 475                 480 
Lys Met Lys Ser Asp Pro Cys Lys Ser Leu Thr Ser Ala Glu Lys Val
                485                 490                 495     
Gly Glu His Ile Leu Lys Glu Gly Leu Thr Ile Trp Asn Gln Lys Gln
            500                 505                 510         
Gly Asn Ser Cys Lys Val Ala Thr Lys Ala Cys Ser Asn Lys Asp Glu
        515                 520                 525             
Lys Gly Glu Lys Ile Asn Ala Ser Thr Asp Ser Leu Ala Lys Asp Leu
    530                 535                 540                 
Ile Val Ser Ala Leu Lys Leu Ile Gln Tyr His Leu Thr Gln Gln Thr
545                 550                 555                 560 
Lys Gly Lys Asp Thr Cys Glu Glu Asp Cys Pro Gly Ser Thr Met Gly
                565                 570                 575     
Tyr Met Ala Gln Ser Thr Gln Tyr Glu Lys Cys Gly Gly Gly Gln Ser
            580                 585                 590         
Ala Lys Ala Leu Ser Val Lys Gln Leu Glu Ser His Arg Ala Pro Gly
        595                 600                 605             
Pro Ser Thr Cys Gln Lys Glu Asn Gln His Leu Asp Ser Gln Lys Met
    610                 615                 620                 
Asp Met Ser Asn Ile Val Leu Met Leu Ile Gln Lys Leu Leu Asn Glu
625                 630                 635                 640 
Asn Pro Phe Lys Cys Glu Asp Pro Cys Glu Gly Glu Asn Lys Cys Ser
                645                 650                 655     
Glu Pro Arg Ala Ser Lys Ala Ala Ser Met Ser Asn Arg Ser Asp Lys
            660                 665                 670         
Ala Glu Glu Gln Cys Gln Glu His Gln Glu Leu Asp Cys Thr Ser Gly
        675                 680                 685             
Met Lys Gln Ala Asn Gly Gln Phe Ile Asp Lys Leu Val Glu Ser Val
    690                 695                 700                 
Met Lys Leu Cys Leu Ile Met Ala Lys Tyr Ser Asn Asp Gly Ala Ala
705                 710                 715                 720 
Leu Ala Glu Leu Glu Glu Gln Ala Ala Ser Ala Asn Lys Pro Asn Phe
                725                 730                 735     
Arg Gly Thr Arg Cys Ile His Ser Gly Ala Met Pro Gln Asn Tyr Gln
            740                 745                 750         
Asp Ser Leu Gly His Glu Val Ile Val Asn Asn Gln Cys Ser Thr Asn
        755                 760                 765             
Ser Leu Gln Lys Gln Leu Gln Ala Val Leu Gln Trp Ile Ala Ala Ser
    770                 775                 780                 
Gln Phe Asn Val Pro Met Leu Tyr Phe Met Gly Asp Lys Asp Gly Gln
785                 790                 795                 800 
Leu Glu Lys Leu Pro Gln Val Ser Ala Lys Ala Ala Glu Lys Gly Tyr
                805                 810                 815     
Ser Val Gly Gly Leu Leu Gln Glu Val Met Lys Phe Ala Lys Glu Arg
            820                 825                 830         
Gln Pro Asp Glu Ala Val Gly Lys Val Ala Arg Lys Gln Leu Leu Asp
        835                 840                 845             
Trp Leu Leu Ala Asn Leu
    850                 


<210> 7323
<211> 548
<212> PRT
<213> Homo sapiens

<400> 7323
Met Ala Lys Phe Met Thr Pro Val Ile Gln Asp Asn Pro Ser Gly Trp
 1               5                  10                  15      
Gly Pro Cys Ala Val Pro Glu Gln Phe Arg Asp Met Pro Tyr Gln Pro
            20                  25                  30          
Phe Ser Lys Gly Asp Arg Leu Gly Lys Val Ala Asp Trp Thr Gly Ala
        35                  40                  45              
Thr Tyr Gln Asp Lys Arg Tyr Thr Asn Lys Tyr Ser Ser Gln Phe Gly
    50                  55                  60                  
Gly Gly Ser Gln Tyr Ala Tyr Phe His Glu Glu Asp Glu Ser Ser Phe
65                  70                  75                  80  
Gln Leu Val Asp Thr Ala Arg Thr Gln Lys Thr Ala Tyr Gln Arg Asn
                85                  90                  95      
Arg Met Arg Phe Ala Gln Arg Asn Leu Arg Arg Asp Lys Asp Arg Arg
            100                 105                 110         
Asn Met Leu Gln Phe Asn Leu Gln Ile Leu Pro Lys Ser Ala Lys Gln
        115                 120                 125             
Lys Glu Arg Glu Arg Ile Arg Leu Gln Lys Lys Phe Gln Lys Gln Phe
    130                 135                 140                 
Gly Val Arg Gln Lys Trp Asp Gln Lys Ser Gln Lys Pro Arg Asp Ser
145                 150                 155                 160 
Ser Val Glu Val Arg Ser Asp Trp Glu Val Lys Glu Glu Met Asp Phe
                165                 170                 175     
Pro Gln Leu Met Lys Met Arg Tyr Leu Glu Val Ser Glu Pro Gln Asp
            180                 185                 190         
Ile Glu Cys Cys Gly Ala Leu Glu Tyr Tyr Asp Lys Ala Phe Asp Arg
        195                 200                 205             
Ile Thr Thr Arg Ser Glu Lys Pro Leu Arg Ser Ile Lys Arg Ile Phe
    210                 215                 220                 
His Thr Val Thr Thr Thr Asp Asp Pro Val Ile Arg Lys Leu Ala Lys
225                 230                 235                 240 
Thr Gln Gly Asn Val Phe Ala Thr Asp Ala Ile Leu Ala Thr Leu Met
                245                 250                 255     
Ser Cys Thr Arg Ser Val Tyr Ser Trp Asp Ile Val Val Gln Arg Val
            260                 265                 270         
Gly Ser Lys Leu Phe Phe Asp Lys Arg Asp Asn Ser Asp Phe Asp Leu
        275                 280                 285             
Leu Thr Val Ser Glu Thr Ala Asn Glu Pro Pro Gln Asp Glu Gly Asn
    290                 295                 300                 
Ser Phe Asn Ser Pro Arg Asn Leu Ala Met Glu Ala Thr Tyr Ile Asn
305                 310                 315                 320 
His Asn Phe Ser Gln Gln Cys Leu Arg Met Gly Lys Glu Arg Tyr Asn
                325                 330                 335     
Phe Pro Asn Pro Asn Pro Phe Val Glu Asp Asp Met Asp Lys Asn Glu
            340                 345                 350         
Ile Ala Ser Val Ala Tyr Arg Tyr Arg Arg Trp Lys Leu Gly Asp Asp
        355                 360                 365             
Ile Asp Leu Ile Val Arg Cys Glu His Asp Gly Val Met Thr Gly Ala
    370                 375                 380                 
Asn Gly Glu Val Ser Phe Ile Asn Ile Lys Thr Leu Asn Glu Trp Asp
385                 390                 395                 400 
Ser Arg His Cys Asn Gly Val Asp Trp Arg Gln Lys Leu Asp Ser Gln
                405                 410                 415     
Arg Gly Ala Val Ile Ala Thr Glu Leu Lys Asn Asn Ser Tyr Lys Leu
            420                 425                 430         
Ala Arg Trp Thr Cys Cys Ala Leu Leu Ala Gly Ser Glu Tyr Leu Lys
        435                 440                 445             
Leu Gly Tyr Val Ser Arg Tyr His Val Lys Asp Ser Ser Arg His Val
    450                 455                 460                 
Ile Leu Gly Thr Gln Gln Phe Lys Pro Asn Glu Phe Ala Ser Gln Ile
465                 470                 475                 480 
Asn Leu Ser Val Glu Asn Ala Trp Gly Ile Leu Arg Cys Val Ile Asp
                485                 490                 495     
Ile Cys Met Lys Leu Glu Glu Gly Lys Tyr Leu Ile Leu Lys Asp Pro
            500                 505                 510         
Asn Lys Gln Val Ile Arg Val Tyr Ser Leu Pro Asp Gly Thr Phe Ser
        515                 520                 525             
Ser Asp Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    530                 535                 540                 
Glu Glu Glu Thr
545             


<210> 7324
<211> 785
<212> PRT
<213> Homo sapiens

<400> 7324
Met Pro Gly Val Ile Pro Ser Glu Ser Asn Gly Leu Ser Arg Gly Ser
 1               5                  10                  15      
Pro Ser Lys Lys Asn Arg Leu Ser Leu Lys Phe Phe Gln Lys Lys Glu
            20                  25                  30          
Thr Lys Arg Ala Leu Asp Phe Thr Asp Ser Gln Glu Asn Glu Glu Lys
        35                  40                  45              
Ala Ser Glu Tyr Arg Ala Ser Glu Ile Asp Gln Val Val Pro Ala Ala
    50                  55                  60                  
Gln Ser Ser Pro Ile Asn Cys Glu Lys Arg Glu Asn Leu Leu Pro Phe
65                  70                  75                  80  
Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn Ser Ile Leu
                85                  90                  95      
Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val Lys His Leu
            100                 105                 110         
Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp Glu Ala Asn
        115                 120                 125             
Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala Ser Tyr Glu
    130                 135                 140                 
Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu Gln Leu Gln
145                 150                 155                 160 
Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu Leu Ala Thr
                165                 170                 175     
Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn Pro Met Tyr
            180                 185                 190         
Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln Cys Ile Leu
        195                 200                 205             
Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu Glu Val Lys
    210                 215                 220                 
Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro His Pro Lys
225                 230                 235                 240 
Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser Met Arg His
                245                 250                 255     
Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly Lys Arg Lys
            260                 265                 270         
Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys Leu Ser Lys
        275                 280                 285             
Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg Ser Lys Arg
    290                 295                 300                 
Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile Ile Pro Lys
305                 310                 315                 320 
Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys Lys Ser Arg
                325                 330                 335     
Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro Ser Ile Leu
            340                 345                 350         
Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln Gly Val Lys
        355                 360                 365             
Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp Leu Gly Lys
    370                 375                 380                 
Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu Ser Pro Gly
385                 390                 395                 400 
Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro Ile Asn Lys
                405                 410                 415     
Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu Phe Gln Gly
            420                 425                 430         
Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser Leu Thr Glu
        435                 440                 445             
Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln Glu Asp Glu
    450                 455                 460                 
Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu Pro Lys Thr
465                 470                 475                 480 
Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala Ser Val Glu
                485                 490                 495     
Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys His His Tyr
            500                 505                 510         
Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro Glu Val Ile
        515                 520                 525             
Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu Phe Asp Cys
    530                 535                 540                 
Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu Thr Pro Leu
545                 550                 555                 560 
Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn Asp Ser Tyr
                565                 570                 575     
Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile Ser Ser Gly
            580                 585                 590         
His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser Leu Glu Leu
        595                 600                 605             
Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile Gly Lys Pro
    610                 615                 620                 
Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu Asn Tyr Asn
625                 630                 635                 640 
Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln Pro Ser Lys
                645                 650                 655     
Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu Gly Gly Gln
            660                 665                 670         
Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser Asn Pro Asp
        675                 680                 685             
Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser Glu Thr Ser
    690                 695                 700                 
Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu Ser Ser Asp
705                 710                 715                 720 
Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile Ser Tyr Val
                725                 730                 735     
Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu Phe Asp Asp
            740                 745                 750         
Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn Ser Leu Ser
        755                 760                 765             
Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe Tyr Lys Lys
    770                 775                 780                 
Leu
785 


<210> 7325
<211> 414
<212> PRT
<213> Homo sapiens

<400> 7325
Met Glu Met Gln Gln Asn Cys Ser Ile Ser Cys Phe Trp Glu Thr Gln
 1               5                  10                  15      
Pro Leu Gly Cys Val Lys Ile Ser Cys Ile Phe Tyr His Ser Lys Pro
            20                  25                  30          
Arg Asn Ile Asn Gly Leu Phe Leu Pro Pro Ser Ser Asn Ile Thr Leu
        35                  40                  45              
Gln Lys Glu Ile Gln Glu Gly Ile Pro Leu Gln Ser Gln Ser Gln Glu
    50                  55                  60                  
Pro Leu Lys Pro Gln Glu Asn Ile Ser Arg Pro Ile His His Pro Leu
65                  70                  75                  80  
Val Leu Lys Thr Asn Phe Glu Glu Glu Glu Glu Val Asp Glu Gln Asn
                85                  90                  95      
Asp Ala Ser Ser Leu Trp Thr Lys Thr Pro Glu Glu Ile Glu Glu Lys
            100                 105                 110         
Arg Ala Ile Lys Glu Met Cys Tyr Lys Ser Gly Glu Tyr Tyr Arg Phe
        115                 120                 125             
His Thr Pro Pro Asp Ile Leu Ser Ser Lys Ser Met Thr Pro Thr Ala
    130                 135                 140                 
Glu Lys Gln Leu Glu Lys Pro Leu Glu Asn Gly Ser Glu Leu Gln Glu
145                 150                 155                 160 
Gly Asp Ser Leu Thr Val Pro Thr Lys Leu Ser Gln Tyr Glu Arg Gln
                165                 170                 175     
Gly Glu Ile Lys Thr Ser Leu His Gly Lys Pro Lys Thr Asp Ile Ala
            180                 185                 190         
Ala Phe Glu Asn Gly Gly Gly Asp Cys Tyr Val Pro Gln Arg Val Ile
        195                 200                 205             
Phe Leu Gly Val Asp Glu Ser Glu Ala Leu Thr Glu Glu Lys Glu Ile
    210                 215                 220                 
Thr Ile Ser Lys Cys Ser Asn Thr Lys Asp Asn Lys Asp Ser Pro His
225                 230                 235                 240 
Pro Lys His Ser Leu Thr Thr Arg Leu Val Pro Thr Thr His Val Leu
                245                 250                 255     
Asn Ala Thr Glu Asn Ile Ser Met Lys Cys Arg Glu Asp Pro Ser Ser
            260                 265                 270         
Met Asn Asp Val Gln Pro Val Lys Lys Pro His Phe Lys Gly Val Lys
        275                 280                 285             
Lys Arg Lys Trp Ile Tyr Asp Glu Pro Gln Asn Phe Pro Asn Ser Gly
    290                 295                 300                 
Met Gln Arg Ala Val Gln Ala Pro Arg Pro Gln Asn Lys Met Ser Tyr
305                 310                 315                 320 
His Arg Asn Asn Lys Asn Arg Asn Ala Glu Asn Ala Ser Tyr Ile His
                325                 330                 335     
Val Gln Arg Asp Ala Val Arg Thr Val Ala Leu Asn Ala Pro Ser Arg
            340                 345                 350         
Ser Arg Pro Thr His Gly Ser Tyr Asn Lys Val His Ala Asn Arg Glu
        355                 360                 365             
Pro Lys Pro Asn Leu Ser Pro Asp Lys Tyr Thr Ser Thr Ser Tyr Asn
    370                 375                 380                 
Asp Ser Ala Trp Arg Lys Arg Ile Pro Phe Ser Lys Thr Tyr Ser Lys
385                 390                 395                 400 
Ser Glu Lys Ile Tyr Pro Glu Pro Arg Arg Asn Gly Ser Lys
                405                 410                 


<210> 7326
<211> 1105
<212> PRT
<213> Homo sapiens

<400> 7326
Met Ala Ala Gly Lys Ser Gly Gly Ser Ala Gly Glu Ile Thr Phe Leu
 1               5                  10                  15      
Glu Ala Leu Ala Arg Ser Glu Ser Lys Arg Asp Gly Gly Phe Lys Asn
            20                  25                  30          
Asn Trp Ser Phe Asp His Glu Glu Glu Ser Glu Gly Asp Thr Asp Lys
        35                  40                  45              
Asp Gly Thr Asn Leu Leu Ser Val Asp Glu Asp Glu Asp Ser Glu Thr
    50                  55                  60                  
Ser Lys Gly Lys Lys Leu Asn Arg Arg Ser Glu Ile Val Ala Asn Ser
65                  70                  75                  80  
Ser Gly Glu Phe Ile Leu Lys Thr Tyr Val Arg Arg Asn Lys Ser Glu
                85                  90                  95      
Ser Phe Lys Thr Leu Lys Gly Asn Pro Ile Gly Leu Asn Met Leu Ser
            100                 105                 110         
Asn Asn Lys Lys Leu Ser Glu Asn Thr Gln Asn Thr Ser Leu Cys Ser
        115                 120                 125             
Gly Thr Val Val His Gly Arg Arg Phe His His Ala His Ala Gln Ile
    130                 135                 140                 
Pro Val Val Lys Thr Ala Ala Gln Arg Lys Glu Tyr Pro Pro His Val
145                 150                 155                 160 
Gln Lys Val Glu Ile Asn Pro Val Arg Leu Ser Arg Leu Gln Gly Val
                165                 170                 175     
Glu Arg Ile Met Lys Lys Thr Glu Glu Ser Glu Ser Gln Val Glu Pro
            180                 185                 190         
Glu Ile Lys Arg Lys Val Gln Gln Lys Arg His Cys Ser Thr Tyr Gln
        195                 200                 205             
Pro Thr Pro Pro Leu Ser Pro Ala Ser Lys Lys Cys Leu Thr His Leu
    210                 215                 220                 
Glu Asp Leu Gln Arg Asn Cys Arg Gln Ala Ile Thr Leu Asn Glu Ser
225                 230                 235                 240 
Thr Gly Pro Leu Leu Arg Thr Ser Ile His Gln Asn Ser Gly Gly Gln
                245                 250                 255     
Lys Ser Gln Asn Thr Gly Leu Thr Thr Lys Lys Phe Tyr Gly Asn Asn
            260                 265                 270         
Val Glu Lys Val Pro Ile Asp Ile Ile Val Asn Cys Asp Asp Ser Lys
        275                 280                 285             
His Thr Tyr Leu Gln Thr Asn Gly Lys Val Ile Leu Pro Gly Ala Lys
    290                 295                 300                 
Ile Pro Lys Ile Thr Asn Leu Lys Glu Arg Lys Thr Ser Leu Ser Asp
305                 310                 315                 320 
Leu Asn Asp Pro Ile Ile Leu Ser Ser Asp Asp Asp Asp Asp Asn Asp
                325                 330                 335     
Arg Thr Asn Arg Arg Glu Ser Ile Ser Pro Gln Pro Ala Asp Ser Ala
            340                 345                 350         
Cys Ser Ser Pro Ala Pro Ser Thr Gly Lys Val Glu Ala Ala Leu Asn
        355                 360                 365             
Glu Asn Thr Cys Arg Ala Glu Arg Glu Leu Arg Ser Ile Pro Glu Asp
    370                 375                 380                 
Ser Glu Leu Asn Thr Val Thr Leu Pro Arg Lys Ala Arg Met Lys Asp
385                 390                 395                 400 
Gln Phe Gly Asn Ser Ile Ile Asn Thr Pro Leu Lys Arg Arg Lys Val
                405                 410                 415     
Phe Ser Gln Glu Pro Pro Asp Ala Leu Ala Leu Ser Cys Gln Ser Ser
            420                 425                 430         
Phe Asp Ser Val Ile Leu Asn Cys Arg Ser Ile Arg Val Gly Thr Leu
        435                 440                 445             
Phe Arg Leu Leu Ile Glu Pro Val Ile Phe Cys Leu Asp Phe Ile Lys
    450                 455                 460                 
Ile Gln Leu Asp Glu Pro Asp His Asp Pro Val Glu Ile Ile Leu Asn
465                 470                 475                 480 
Thr Ser Asp Leu Thr Lys Cys Glu Trp Cys Asn Val Arg Lys Leu Pro
                485                 490                 495     
Val Val Phe Leu Gln Ala Ile Pro Ala Val Tyr Gln Lys Leu Ser Ile
            500                 505                 510         
Gln Leu Gln Met Asn Lys Glu Asp Lys Val Trp Asn Asp Cys Lys Gly
        515                 520                 525             
Val Asn Lys Leu Thr Asn Leu Glu Glu Gln Tyr Ile Ile Leu Ile Phe
    530                 535                 540                 
Gln Asn Gly Leu Asp Pro Pro Ala Asn Met Val Phe Glu Ser Ile Ile
545                 550                 555                 560 
Asn Glu Ile Gly Ile Lys Asn Asn Ile Ser Asn Phe Phe Ala Lys Ile
                565                 570                 575     
Pro Phe Glu Glu Ala Asn Gly Arg Leu Val Ala Cys Thr Arg Thr Tyr
            580                 585                 590         
Glu Glu Ser Ile Lys Gly Ser Cys Gly Gln Lys Glu Asn Lys Ile Lys
        595                 600                 605             
Thr Val Ser Phe Glu Ser Lys Ile Gln Leu Arg Ser Lys Gln Glu Phe
    610                 615                 620                 
Gln Phe Phe Asp Glu Glu Glu Glu Thr Gly Glu Asn His Thr Ile Phe
625                 630                 635                 640 
Ile Gly Pro Val Glu Lys Leu Ile Val Tyr Pro Pro Pro Pro Ala Lys
                645                 650                 655     
Gly Gly Ile Ser Val Thr Asn Glu Asp Leu His Cys Leu Asn Glu Gly
            660                 665                 670         
Glu Phe Leu Asn Asp Val Ile Ile Asp Phe Tyr Leu Lys Tyr Leu Val
        675                 680                 685             
Leu Glu Lys Leu Lys Lys Glu Asp Ala Asp Arg Ile His Ile Phe Ser
    690                 695                 700                 
Ser Phe Phe Tyr Lys Arg Leu Asn Gln Arg Glu Arg Arg Asn His Glu
705                 710                 715                 720 
Thr Thr Asn Leu Ser Ile Gln Gln Lys Arg His Gly Arg Val Lys Thr
                725                 730                 735     
Trp Thr Arg His Val Asp Ile Phe Glu Lys Asp Phe Ile Phe Val Pro
            740                 745                 750         
Leu Asn Glu Ala Ala His Trp Phe Leu Ala Val Val Cys Phe Pro Gly
        755                 760                 765             
Leu Glu Lys Pro Lys Tyr Glu Pro Asn Pro His Tyr His Glu Asn Ala
    770                 775                 780                 
Val Ile Gln Lys Cys Ser Thr Val Glu Asp Ser Cys Ile Ser Ser Ser
785                 790                 795                 800 
Ala Ser Glu Met Glu Ser Cys Ser Gln Asn Ser Ser Ala Lys Pro Val
                805                 810                 815     
Ile Lys Lys Met Leu Asn Lys Lys His Cys Ile Ala Val Ile Asp Ser
            820                 825                 830         
Asn Pro Gly Gln Glu Glu Ser Asp Pro Arg Tyr Lys Arg Asn Ile Cys
        835                 840                 845             
Ser Val Lys Tyr Ser Val Lys Lys Ile Asn His Thr Ala Ser Glu Asn
    850                 855                 860                 
Glu Glu Phe Asn Lys Gly Glu Ser Thr Ser Gln Lys Val Ala Asp Arg
865                 870                 875                 880 
Thr Lys Ser Glu Asn Gly Leu Gln Asn Glu Ser Leu Ser Ser Thr His
                885                 890                 895     
His Thr Asp Gly Leu Ser Lys Ile Arg Leu Asn Tyr Ser Asp Glu Ser
            900                 905                 910         
Pro Glu Ala Gly Lys Met Leu Glu Asp Glu Leu Val Asp Phe Ser Glu
        915                 920                 925             
Asp Gln Asp Asn Gln Asp Asp Ser Ser Asp Asp Gly Phe Leu Ala Asp
    930                 935                 940                 
Asp Asn Cys Ser Ser Glu Ile Gly Gln Trp His Leu Lys Pro Thr Ile
945                 950                 955                 960 
Cys Lys Gln Pro Cys Ile Leu Leu Met Asp Ser Leu Arg Gly Pro Ser
                965                 970                 975     
Arg Ser Asn Val Val Lys Ile Leu Arg Glu Tyr Leu Glu Val Glu Trp
            980                 985                 990         
Glu Val Lys Lys Gly Ser Lys Arg Ser Phe Ser Lys Asp Val Met Lys
        995                 1000                1005            
Gly Ser Asn Pro Lys Val Pro Gln Gln Asn Asn Phe Ser Asp Cys Gly
    1010                1015                1020                
Val Tyr Val Leu Gln Tyr Val Glu Ser Phe Phe Gln Asn Pro Ile Leu
1025                1030                1035                1040
Ser Phe Glu Leu Pro Met Asn Leu Ala Asn Trp Phe Pro Pro Pro Arg
                1045                1050                1055    
Met Arg Thr Lys Arg Glu Glu Ile Arg Asn Ile Ile Leu Lys Leu Gln
            1060                1065                1070        
Glu Asp Gln Ser Lys Glu Lys Arg Lys His Lys Asp Thr Tyr Ser Thr
        1075                1080                1085            
Glu Ala Pro Leu Gly Glu Gly Thr Glu Gln Tyr Val Asn Ser Ile Ser
    1090                1095                1100                
Asp
1105


<210> 7327
<211> 1112
<212> PRT
<213> Homo sapiens

<400> 7327
Met Ala Ala Gly Lys Ser Gly Gly Ser Ala Gly Glu Ile Thr Phe Leu
 1               5                  10                  15      
Glu Ala Leu Ala Arg Ser Glu Ser Lys Arg Asp Gly Gly Phe Lys Asn
            20                  25                  30          
Asn Trp Ser Phe Asp His Glu Glu Glu Ser Glu Gly Asp Thr Asp Lys
        35                  40                  45              
Asp Gly Thr Asn Leu Leu Ser Val Asp Glu Asp Glu Asp Ser Glu Thr
    50                  55                  60                  
Ser Lys Gly Lys Lys Leu Asn Arg Arg Ser Glu Ile Val Ala Asn Ser
65                  70                  75                  80  
Ser Gly Glu Phe Ile Leu Lys Thr Tyr Val Arg Arg Asn Lys Ser Glu
                85                  90                  95      
Ser Phe Lys Thr Leu Lys Gly Asn Pro Ile Gly Leu Asn Met Leu Ser
            100                 105                 110         
Asn Asn Lys Lys Leu Ser Glu Asn Thr Gln Asn Thr Ser Leu Cys Ser
        115                 120                 125             
Gly Thr Val Val His Gly Arg Arg Phe His His Ala His Ala Gln Ile
    130                 135                 140                 
Pro Val Val Lys Thr Ala Ala Gln Ser Ser Leu Asp Arg Lys Glu Arg
145                 150                 155                 160 
Lys Glu Tyr Pro Pro His Val Gln Lys Val Glu Ile Asn Pro Val Arg
                165                 170                 175     
Leu Ser Arg Leu Gln Gly Val Glu Arg Ile Met Lys Lys Thr Glu Glu
            180                 185                 190         
Ser Glu Ser Gln Val Glu Pro Glu Ile Lys Arg Lys Val Gln Gln Lys
        195                 200                 205             
Arg His Cys Ser Thr Tyr Gln Pro Thr Pro Pro Leu Ser Pro Ala Ser
    210                 215                 220                 
Lys Lys Cys Leu Thr His Leu Glu Asp Leu Gln Arg Asn Cys Arg Gln
225                 230                 235                 240 
Ala Ile Thr Leu Asn Glu Ser Thr Gly Pro Leu Leu Arg Thr Ser Ile
                245                 250                 255     
His Gln Asn Ser Gly Gly Gln Lys Ser Gln Asn Thr Gly Leu Thr Thr
            260                 265                 270         
Lys Lys Phe Tyr Gly Asn Asn Val Glu Lys Val Pro Ile Asp Ile Ile
        275                 280                 285             
Val Asn Cys Asp Asp Ser Lys His Thr Tyr Leu Gln Thr Asn Gly Lys
    290                 295                 300                 
Val Ile Leu Pro Gly Ala Lys Ile Pro Lys Ile Thr Asn Leu Lys Glu
305                 310                 315                 320 
Arg Lys Thr Ser Leu Ser Asp Leu Asn Asp Pro Ile Ile Leu Ser Ser
                325                 330                 335     
Asp Asp Asp Asp Asp Asn Asp Arg Thr Asn Arg Arg Glu Ser Ile Ser
            340                 345                 350         
Pro Gln Pro Ala Asp Ser Ala Cys Ser Ser Pro Ala Pro Ser Thr Gly
        355                 360                 365             
Lys Val Glu Ala Ala Leu Asn Glu Asn Thr Cys Arg Ala Glu Arg Glu
    370                 375                 380                 
Leu Arg Ser Ile Pro Glu Asp Ser Glu Leu Asn Thr Val Thr Leu Pro
385                 390                 395                 400 
Arg Lys Ala Arg Met Lys Asp Gln Phe Gly Asn Ser Ile Ile Asn Thr
                405                 410                 415     
Pro Leu Lys Arg Arg Lys Val Phe Ser Gln Glu Pro Pro Asp Ala Leu
            420                 425                 430         
Ala Leu Ser Cys Gln Ser Ser Phe Asp Ser Val Ile Leu Asn Cys Arg
        435                 440                 445             
Ser Ile Arg Val Gly Thr Leu Phe Arg Leu Leu Ile Glu Pro Val Ile
    450                 455                 460                 
Phe Cys Leu Asp Phe Ile Lys Ile Gln Leu Asp Glu Pro Asp His Asp
465                 470                 475                 480 
Pro Val Glu Ile Ile Leu Asn Thr Ser Asp Leu Thr Lys Cys Glu Trp
                485                 490                 495     
Cys Asn Val Arg Lys Leu Pro Val Val Phe Leu Gln Ala Ile Pro Ala
            500                 505                 510         
Val Tyr Gln Lys Leu Ser Ile Gln Leu Gln Met Asn Lys Glu Asp Lys
        515                 520                 525             
Val Trp Asn Asp Cys Lys Gly Val Asn Lys Leu Thr Asn Leu Glu Glu
    530                 535                 540                 
Gln Tyr Ile Ile Leu Ile Phe Gln Asn Gly Leu Asp Pro Pro Ala Asn
545                 550                 555                 560 
Met Val Phe Glu Ser Ile Ile Asn Glu Ile Gly Ile Lys Asn Asn Ile
                565                 570                 575     
Ser Asn Phe Phe Ala Lys Ile Pro Phe Glu Glu Ala Asn Gly Arg Leu
            580                 585                 590         
Val Ala Cys Thr Arg Thr Tyr Glu Glu Ser Ile Lys Gly Ser Cys Gly
        595                 600                 605             
Gln Lys Glu Asn Lys Ile Lys Thr Val Ser Phe Glu Ser Lys Ile Gln
    610                 615                 620                 
Leu Arg Ser Lys Gln Glu Phe Gln Phe Phe Asp Glu Glu Glu Glu Thr
625                 630                 635                 640 
Gly Glu Asn His Thr Ile Phe Ile Gly Pro Val Glu Lys Leu Ile Val
                645                 650                 655     
Tyr Pro Pro Pro Pro Ala Lys Gly Gly Ile Ser Val Thr Asn Glu Asp
            660                 665                 670         
Leu His Cys Leu Asn Glu Gly Glu Phe Leu Asn Asp Val Ile Ile Asp
        675                 680                 685             
Phe Tyr Leu Lys Tyr Leu Val Leu Glu Lys Leu Lys Lys Glu Asp Ala
    690                 695                 700                 
Asp Arg Ile His Ile Phe Ser Ser Phe Phe Tyr Lys Arg Leu Asn Gln
705                 710                 715                 720 
Arg Glu Arg Arg Asn His Glu Thr Thr Asn Leu Ser Ile Gln Gln Lys
                725                 730                 735     
Arg His Gly Arg Val Lys Thr Trp Thr Arg His Val Asp Ile Phe Glu
            740                 745                 750         
Lys Asp Phe Ile Phe Val Pro Leu Asn Glu Ala Ala His Trp Phe Leu
        755                 760                 765             
Ala Val Val Cys Phe Pro Gly Leu Glu Lys Pro Lys Tyr Glu Pro Asn
    770                 775                 780                 
Pro His Tyr His Glu Asn Ala Val Ile Gln Lys Cys Ser Thr Val Glu
785                 790                 795                 800 
Asp Ser Cys Ile Ser Ser Ser Ala Ser Glu Met Glu Ser Cys Ser Gln
                805                 810                 815     
Asn Ser Ser Ala Lys Pro Val Ile Lys Lys Met Leu Asn Lys Lys His
            820                 825                 830         
Cys Ile Ala Val Ile Asp Ser Asn Pro Gly Gln Glu Glu Ser Asp Pro
        835                 840                 845             
Arg Tyr Lys Arg Asn Ile Cys Ser Val Lys Tyr Ser Val Lys Lys Ile
    850                 855                 860                 
Asn His Thr Ala Ser Glu Asn Glu Glu Phe Asn Lys Gly Glu Ser Thr
865                 870                 875                 880 
Ser Gln Lys Val Ala Asp Arg Thr Lys Ser Glu Asn Gly Leu Gln Asn
                885                 890                 895     
Glu Ser Leu Ser Ser Thr His His Thr Asp Gly Leu Ser Lys Ile Arg
            900                 905                 910         
Leu Asn Tyr Ser Asp Glu Ser Pro Glu Ala Gly Lys Met Leu Glu Asp
        915                 920                 925             
Glu Leu Val Asp Phe Ser Glu Asp Gln Asp Asn Gln Asp Asp Ser Ser
    930                 935                 940                 
Asp Asp Gly Phe Leu Ala Asp Asp Asn Cys Ser Ser Glu Ile Gly Gln
945                 950                 955                 960 
Trp His Leu Lys Pro Thr Ile Cys Lys Gln Pro Cys Ile Leu Leu Met
                965                 970                 975     
Asp Ser Leu Arg Gly Pro Ser Arg Ser Asn Val Val Lys Ile Leu Arg
            980                 985                 990         
Glu Tyr Leu Glu Val Glu Trp Glu Val Lys Lys Gly Ser Lys Arg Ser
        995                 1000                1005            
Phe Ser Lys Asp Val Met Lys Gly Ser Asn Pro Lys Val Pro Gln Gln
    1010                1015                1020                
Asn Asn Phe Ser Asp Cys Gly Val Tyr Val Leu Gln Tyr Val Glu Ser
1025                1030                1035                1040
Phe Phe Gln Asn Pro Ile Leu Ser Phe Glu Leu Pro Met Asn Leu Ala
                1045                1050                1055    
Asn Trp Phe Pro Pro Pro Arg Met Arg Thr Lys Arg Glu Glu Ile Arg
            1060                1065                1070        
Asn Ile Ile Leu Lys Leu Gln Glu Asp Gln Ser Lys Glu Lys Arg Lys
        1075                1080                1085            
His Lys Asp Thr Tyr Ser Thr Glu Ala Pro Leu Gly Glu Gly Thr Glu
    1090                1095                1100                
Gln Tyr Val Asn Ser Ile Ser Asp
1105                1110        


<210> 7328
<211> 318
<212> PRT
<213> Homo sapiens

<400> 7328
Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Pro Ala
 1               5                  10                  15      
Ala Pro Ala Leu Pro Pro Thr Pro Ser Pro Ala Leu Arg Arg Arg Arg
            20                  25                  30          
Glu Arg Trp Pro Gly Arg Thr Ser Ala Ala Pro Ala Gly Gly Asp Lys
        35                  40                  45              
Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys Trp Phe Asn Val
    50                  55                  60                  
Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp Val
65                  70                  75                  80  
Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro Arg Lys Tyr Leu
                85                  90                  95      
Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp Val Val Glu Gly
            100                 105                 110         
Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro Gly Gly Val Pro
        115                 120                 125             
Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His Tyr Arg Arg Tyr
    130                 135                 140                 
Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln Asn Tyr Gln Asn
145                 150                 155                 160 
Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser Ala Pro Glu Gly
                165                 170                 175     
Gln Ala Gln Gln Arg Arg Pro Tyr Arg Arg Arg Arg Phe Pro Pro Tyr
            180                 185                 190         
Tyr Met Arg Arg Pro Tyr Gly Arg Arg Pro Gln Tyr Ser Asn Pro Pro
        195                 200                 205             
Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln Gly Ala Gly Glu
    210                 215                 220                 
Gln Gly Arg Pro Val Arg Gln Cys Ile Gly Asp Ile Asp His Asp Ser
225                 230                 235                 240 
Ala Gly Ala Leu Leu Ala Arg Gln Pro Arg Glu Asp Gly Asn Glu Glu
                245                 250                 255     
Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln Gly Gln Gln Pro Pro Gln
            260                 265                 270         
Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg Arg Arg Arg Pro Glu Asn
        275                 280                 285             
Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys Ala Ala Asp Pro Pro Ala
    290                 295                 300                 
Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln Gly Gly Ala Glu
305                 310                 315             


<210> 7329
<211> 342
<212> PRT
<213> Homo sapiens

<400> 7329
Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro
 1               5                  10                  15      
Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro
            20                  25                  30          
Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro
        35                  40                  45              
Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala
    50                  55                  60                  
Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Ala Ala Ala Gly Ser Glu
65                  70                  75                  80  
Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys
                85                  90                  95      
Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
            100                 105                 110         
Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
        115                 120                 125             
Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
    130                 135                 140                 
Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
145                 150                 155                 160 
Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg
                165                 170                 175     
Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Tyr
            180                 185                 190         
Ala Gly Glu Glu Glu Glu Glu Gly Ser Gly Ser Ser Glu Gly Phe Asp
        195                 200                 205             
Pro Pro Ala Thr Asp Arg Gln Phe Ser Gly Ala Arg Asn Gln Leu Arg
    210                 215                 220                 
Arg Pro Gln Tyr Arg Pro Gln Tyr Arg Gln Arg Arg Phe Pro Pro Tyr
225                 230                 235                 240 
His Val Gly Gln Thr Phe Asp Arg Arg Ser Arg Val Leu Pro His Pro
                245                 250                 255     
Asn Arg Ile Gln Ala Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro
            260                 265                 270         
Glu Gly Ala Gln Leu Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg
        275                 280                 285             
Pro Arg Tyr Arg Ser Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala
    290                 295                 300                 
Val Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro
305                 310                 315                 320 
Asn Gln Pro Ser Val Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg
                325                 330                 335     
Arg Arg Pro Pro Ser Ser
            340         


<210> 7330
<211> 324
<212> PRT
<213> Homo sapiens

<400> 7330
Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Pro Ala
 1               5                  10                  15      
Ala Pro Ala Leu Ser Ala Ala Asp Thr Lys Pro Gly Thr Thr Gly Ser
            20                  25                  30          
Gly Ala Gly Ser Gly Gly Pro Gly Gly Leu Thr Ser Ala Ala Pro Ala
        35                  40                  45              
Gly Gly Asp Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys
    50                  55                  60                  
Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
65                  70                  75                  80  
Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
                85                  90                  95      
Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
            100                 105                 110         
Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
        115                 120                 125             
Gly Gly Val Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His
    130                 135                 140                 
Tyr Arg Arg Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln
145                 150                 155                 160 
Asn Tyr Gln Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser
                165                 170                 175     
Ala Pro Glu Gly Gln Ala Gln Gln Arg Arg Pro Tyr Arg Arg Arg Arg
            180                 185                 190         
Phe Pro Pro Tyr Tyr Met Arg Arg Pro Tyr Gly Arg Arg Pro Gln Tyr
        195                 200                 205             
Ser Asn Pro Pro Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln
    210                 215                 220                 
Gly Ala Gly Glu Gln Gly Arg Pro Val Arg Gln Asn Met Tyr Arg Gly
225                 230                 235                 240 
Tyr Arg Pro Arg Phe Arg Arg Gly Pro Pro Arg Gln Arg Gln Pro Arg
                245                 250                 255     
Glu Asp Gly Asn Glu Glu Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln
            260                 265                 270         
Gly Gln Gln Pro Pro Gln Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg
        275                 280                 285             
Arg Arg Arg Pro Glu Asn Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys
    290                 295                 300                 
Ala Ala Asp Pro Pro Ala Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln
305                 310                 315                 320 
Gly Gly Ala Glu
                


<210> 7331
<211> 318
<212> PRT
<213> Homo sapiens

<400> 7331
Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Pro Ala
 1               5                  10                  15      
Ala Pro Ala Leu Ser Ala Ala Asp Thr Lys Pro Gly Thr Thr Gly Ser
            20                  25                  30          
Gly Ala Gly Ser Gly Gly Pro Gly Gly Leu Thr Ser Ala Ala Pro Ala
        35                  40                  45              
Gly Gly Asp Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys
    50                  55                  60                  
Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
65                  70                  75                  80  
Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
                85                  90                  95      
Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
            100                 105                 110         
Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
        115                 120                 125             
Gly Gly Val Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His
    130                 135                 140                 
Tyr Arg Arg Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln
145                 150                 155                 160 
Asn Tyr Gln Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser
                165                 170                 175     
Ala Pro Glu Arg Pro Asn Asn Ala Gly Pro Gln Ala Lys Val Pro Thr
            180                 185                 190         
Leu Leu His Ala Glu Tyr Gly Arg Arg Pro Gln Tyr Ser Asn Pro Pro
        195                 200                 205             
Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln Gly Ala Gly Glu
    210                 215                 220                 
Gln Gly Arg Pro Val Arg Gln Cys Ile Gly Asp Ile Asp His Asp Ser
225                 230                 235                 240 
Ala Gly Ala Leu Leu Ala Arg Gln Pro Arg Glu Asp Gly Asn Glu Glu
                245                 250                 255     
Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln Gly Gln Gln Pro Pro Gln
            260                 265                 270         
Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg Arg Arg Arg Pro Glu Asn
        275                 280                 285             
Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys Ala Ala Asp Pro Pro Ala
    290                 295                 300                 
Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln Gly Gly Ala Glu
305                 310                 315             


<210> 7332
<211> 303
<212> PRT
<213> Homo sapiens

<400> 7332
Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro
 1               5                  10                  15      
Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro
            20                  25                  30          
Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro
        35                  40                  45              
Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala
    50                  55                  60                  
Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Thr Ala Ala Gly Ser Glu
65                  70                  75                  80  
Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys
                85                  90                  95      
Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
            100                 105                 110         
Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
        115                 120                 125             
Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
    130                 135                 140                 
Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
145                 150                 155                 160 
Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg
                165                 170                 175     
Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Ala
            180                 185                 190         
Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro Glu Gly Ala Gln Leu
        195                 200                 205             
Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg Pro Arg Tyr Arg Ser
    210                 215                 220                 
Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala Val Gly Glu Ala Glu
225                 230                 235                 240 
Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro Asn Gln Pro Ser Val
                245                 250                 255     
Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg Arg Arg Pro Arg Pro
            260                 265                 270         
Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala Lys Ala Gly Glu Ala
        275                 280                 285             
Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln Ser Ser Ala Glu
    290                 295                 300             


<210> 7333
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7333
Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro
 1               5                  10                  15      
Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro
            20                  25                  30          
Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro
        35                  40                  45              
Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala
    50                  55                  60                  
Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Ala Ala Ala Gly Ser Glu
65                  70                  75                  80  
Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys
                85                  90                  95      
Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
            100                 105                 110         
Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
        115                 120                 125             
Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
    130                 135                 140                 
Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
145                 150                 155                 160 
Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg
                165                 170                 175     
Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Tyr
            180                 185                 190         
Ala Gly Glu Glu Glu Glu Glu Gly Ser Gly Ser Ser Glu Gly Phe Asp
        195                 200                 205             
Pro Pro Ala Thr Asp Arg Gln Phe Ser Gly Ala Arg Asn Gln Leu Arg
    210                 215                 220                 
Arg Pro Gln Tyr Arg Pro Gln Tyr Arg Gln Arg Arg Phe Pro Pro Tyr
225                 230                 235                 240 
His Val Gly Gln Thr Phe Asp Arg Arg Ser Arg Val Leu Pro His Pro
                245                 250                 255     
Asn Arg Ile Gln Ala Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro
            260                 265                 270         
Glu Gly Ala Gln Leu Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg
        275                 280                 285             
Pro Arg Tyr Arg Ser Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala
    290                 295                 300                 
Val Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro
305                 310                 315                 320 
Asn Gln Pro Ser Val Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg
                325                 330                 335     
Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala
            340                 345                 350         
Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln
        355                 360                 365             
Ser Ser Ala Glu
    370         


<210> 7334
<211> 320
<212> PRT
<213> Homo sapiens

<400> 7334
Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Pro Ala
 1               5                  10                  15      
Ala Pro Ala Leu Arg Pro Pro Thr Pro Ser Pro Ala Leu Arg Arg Arg
            20                  25                  30          
Arg Glu Arg Trp Pro Gly Arg Leu Thr Ser Ala Ala Leu Arg Arg Asp
        35                  40                  45              
Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys Trp Phe Asn
    50                  55                  60                  
Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp
65                  70                  75                  80  
Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro Arg Lys Tyr
                85                  90                  95      
Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp Val Val Glu
            100                 105                 110         
Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro Gly Gly Val
        115                 120                 125             
Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His Tyr Arg Arg
    130                 135                 140                 
Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln Asn Tyr Gln
145                 150                 155                 160 
Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser Ala Pro Glu
                165                 170                 175     
Ala Arg Pro Asn Asn Ala Ala Ala Tyr Ala Gly Glu Val Pro Thr Leu
            180                 185                 190         
Leu His Ala Glu Thr Tyr Gly Arg Arg Pro Gln Tyr Ser Asn Pro Pro
        195                 200                 205             
Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln Gly Ala Gly Glu
    210                 215                 220                 
Gln Gly Arg Pro Val Arg Gln Ile Cys Ile Gly Asp Ile Asp His Asp
225                 230                 235                 240 
Ser Ala Gly Ala Leu Leu Ala Lys Arg Gln Pro Arg Glu Asp Gly Asn
                245                 250                 255     
Glu Glu Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln Gly Gln Gln Pro
            260                 265                 270         
Pro Gln Ala Arg Tyr Arg Arg Asn Phe Asn Tyr Arg Arg Arg Arg Pro
        275                 280                 285             
Glu Asn Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys Ala Ala Asp Pro
    290                 295                 300                 
Pro Ala Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln Gly Gly Ala Glu
305                 310                 315                 320 


<210> 7335
<211> 303
<212> PRT
<213> Homo sapiens

<400> 7335
Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro
 1               5                  10                  15      
Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro
            20                  25                  30          
Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro
        35                  40                  45              
Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala
    50                  55                  60                  
Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Ala Ala Ala Gly Ser Glu
65                  70                  75                  80  
Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys
                85                  90                  95      
Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
            100                 105                 110         
Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
        115                 120                 125             
Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
    130                 135                 140                 
Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
145                 150                 155                 160 
Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg
                165                 170                 175     
Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Ala
            180                 185                 190         
Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro Glu Gly Ala Gln Leu
        195                 200                 205             
Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg Pro Arg Tyr Arg Ser
    210                 215                 220                 
Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala Val Gly Glu Ala Glu
225                 230                 235                 240 
Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro Asn Gln Pro Ser Val
                245                 250                 255     
Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg Arg Arg Pro Arg Pro
            260                 265                 270         
Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala Lys Ala Gly Glu Ala
        275                 280                 285             
Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln Ser Ser Ala Glu
    290                 295                 300             


<210> 7336
<211> 763
<212> PRT
<213> Homo sapiens

<400> 7336
Met Asp His Leu Asn Glu Ala Thr Gln Gly Lys Glu His Ser Glu Met
 1               5                  10                  15      
Ser Asn Asn Val Ser Asp Pro Lys Gly Pro Pro Ala Lys Ile Ala Arg
            20                  25                  30          
Leu Glu Gln Asn Gly Ser Pro Leu Gly Arg Gly Arg Leu Gly Ser Thr
        35                  40                  45              
Gly Ala Lys Met Gln Gly Val Pro Leu Lys His Ser Gly His Leu Met
    50                  55                  60                  
Lys Thr Asn Leu Arg Lys Gly Thr Met Leu Pro Val Phe Cys Val Val
65                  70                  75                  80  
Glu His Tyr Glu Asn Ala Ile Glu Tyr Asp Cys Lys Glu Glu His Ala
                85                  90                  95      
Glu Phe Val Leu Val Arg Lys Asp Met Leu Phe Asn Gln Leu Ile Glu
            100                 105                 110         
Met Ala Leu Leu Ser Leu Gly Tyr Ser His Ser Ser Ala Ala Gln Ala
        115                 120                 125             
Lys Gly Leu Ile Gln Val Gly Lys Trp Asn Pro Val Pro Leu Ser Tyr
    130                 135                 140                 
Val Thr Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln Asp Val
145                 150                 155                 160 
Tyr His Val Val Thr Leu Lys Ile Gln Leu His Ser Cys Pro Lys Leu
                165                 170                 175     
Glu Asp Leu Pro Pro Glu Gln Trp Ser His Thr Thr Val Arg Asn Ala
            180                 185                 190         
Leu Lys Asp Leu Leu Lys Asp Met Asn Gln Ser Ser Leu Ala Lys Glu
        195                 200                 205             
Cys Pro Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser Thr Tyr
    210                 215                 220                 
Tyr Ala Asn Val Ser Ala Ala Lys Cys Gln Glu Phe Gly Arg Trp Tyr
225                 230                 235                 240 
Lys His Phe Lys Lys Thr Lys Asp Met Met Val Glu Met Asp Ser Leu
                245                 250                 255     
Ser Glu Leu Ser Gln Gln Gly Ala Asn His Val Asn Phe Gly Gln Gln
            260                 265                 270         
Pro Val Pro Gly Asn Thr Ala Glu Gln Pro Pro Ser Pro Ala Gln Leu
        275                 280                 285             
Ser His Gly Ser Gln Pro Ser Val Arg Thr Pro Leu Pro Asn Leu His
    290                 295                 300                 
Pro Gly Leu Val Ser Thr Pro Ile Ser Pro Gln Leu Val Asn Gln Gln
305                 310                 315                 320 
Leu Val Met Ala Gln Leu Leu Asn Gln Gln Tyr Ala Val Asn Arg Leu
                325                 330                 335     
Leu Ala Gln Gln Ser Leu Asn Gln Gln Tyr Leu Asn His Pro Pro Pro
            340                 345                 350         
Val Ser Arg Ser Met Asn Lys Pro Leu Glu Gln Gln Val Ser Thr Asn
        355                 360                 365             
Thr Glu Val Ser Ser Glu Ile Tyr Gln Trp Val Arg Asp Glu Leu Lys
    370                 375                 380                 
Arg Ala Gly Ile Ser Gln Ala Val Phe Ala Arg Val Ala Phe Asn Arg
385                 390                 395                 400 
Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys Glu Glu Asp Pro Lys
                405                 410                 415     
Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg Ala Met Gln Asn Phe
            420                 425                 430         
Leu Gln Leu Pro Glu Ala Glu Arg Asp Arg Ile Tyr Gln Asp Glu Arg
        435                 440                 445             
Glu Arg Ser Leu Asn Ala Ala Ser Ala Met Gly Pro Ala Pro Leu Ile
    450                 455                 460                 
Ser Thr Pro Pro Ser Arg Pro Pro Gln Val Lys Thr Ala Thr Ile Ala
465                 470                 475                 480 
Thr Glu Arg Asn Gly Lys Pro Glu Asn Asn Thr Met Asn Ile Asn Ala
                485                 490                 495     
Ser Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys Arg Ala Lys Val Ser
            500                 505                 510         
Gln Ala Leu Phe Ala Lys Val Ala Ala Thr Lys Ser Gln Gly Trp Leu
        515                 520                 525             
Cys Glu Leu Leu Arg Trp Lys Glu Asp Pro Ser Pro Glu Asn Arg Thr
    530                 535                 540                 
Leu Trp Glu Asn Leu Ser Met Ile Arg Arg Phe Leu Ser Leu Pro Gln
545                 550                 555                 560 
Pro Glu Arg Asp Ala Ile Tyr Glu Gln Glu Ser Asn Ala Val His His
                565                 570                 575     
His Gly Asp Arg Pro Pro His Ile Ile His Val Pro Ala Glu Gln Ile
            580                 585                 590         
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala
        595                 600                 605             
Pro Pro Pro Pro Gln Pro Gln Gln Gln Pro Gln Thr Gly Pro Arg Leu
    610                 615                 620                 
Pro Pro Arg Gln Pro Thr Val Ala Ser Pro Ala Glu Ser Asp Glu Glu
625                 630                 635                 640 
Asn Arg Gln Lys Thr Arg Pro Arg Thr Lys Ile Ser Val Glu Ala Leu
                645                 650                 655     
Gly Ile Leu Gln Ser Phe Ile Gln Asp Val Gly Leu Tyr Pro Asp Glu
            660                 665                 670         
Glu Ala Ile Gln Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys Tyr Thr
        675                 680                 685             
Ile Ile Lys Phe Phe Gln Asn Gln Arg Tyr Tyr Leu Lys His His Gly
    690                 695                 700                 
Lys Leu Lys Asp Asn Ser Gly Leu Glu Val Asp Val Ala Glu Tyr Lys
705                 710                 715                 720 
Glu Glu Glu Leu Leu Lys Asp Leu Glu Glu Ser Val Gln Asp Lys Asn
                725                 730                 735     
Thr Asn Thr Leu Phe Ser Val Lys Leu Glu Glu Glu Leu Ser Val Glu
            740                 745                 750         
Gly Asn Thr Asp Ile Asn Thr Asp Leu Lys Asp
        755                 760             


<210> 7337
<211> 853
<212> PRT
<213> Homo sapiens

<400> 7337
Met Cys Cys Glu Lys Trp Ser Arg Val Ala Glu Met Phe Leu Phe Thr
 1               5                  10                  15      
Glu Glu Arg Glu Asp Cys Lys Ile Leu Cys Leu Cys Ser Arg Ala Phe
            20                  25                  30          
Val Glu Asp Arg Lys Leu Tyr Asn Leu Gly Leu Lys Gly Tyr Tyr Ile
        35                  40                  45              
Arg Asp Ser Gly Asn Asn Ser Gly Asp Gln Ala Thr Glu Glu Glu Glu
    50                  55                  60                  
Gly Gly Tyr Ser Cys Gly Thr Ala Glu Ser His Asp Ser Lys Gly Ile
65                  70                  75                  80  
Gly Leu Asp Glu Ser Glu Leu Asp Ser Glu Ala Glu Leu Met Arg Ser
                85                  90                  95      
Met Gly Leu Pro Leu Gln Phe Gly Arg Ile Thr Ala His Lys Asp Phe
            100                 105                 110         
Glu Val Ser Met Asn Thr Arg Asn Lys Val Lys Ile Lys Lys Lys Lys
        115                 120                 125             
His Gln Lys Lys Tyr Leu Asp Glu Ile Val Gln Glu Ser Trp Arg Lys
    130                 135                 140                 
Glu Tyr Glu Glu Asp Asp Ile Leu Ala Ser Asp Asp Pro Ser Ser Ile
145                 150                 155                 160 
Glu Gln Tyr Glu Asn Thr Arg Thr Tyr Glu Leu Gln Ser Lys Lys Asp
                165                 170                 175     
Thr Glu Thr Glu Asn Pro Pro Val Glu Asn Thr Leu Ser Pro Lys Leu
            180                 185                 190         
Glu Ile Thr Glu Lys Trp Glu Lys Tyr Trp Asn Glu Tyr Gly Gly Gly
        195                 200                 205             
Leu Leu Trp Gln Ser Trp Gln Glu Lys His Pro Gly Gln Ala Leu Ser
    210                 215                 220                 
Ser Glu Pro Trp Asn Phe Pro Asp Thr Lys Glu Glu Trp Glu Gln His
225                 230                 235                 240 
Tyr Ser Gln Leu Tyr Trp Tyr Tyr Leu Glu Gln Phe Gln Tyr Trp Glu
                245                 250                 255     
Ala Gln Gly Trp Thr Phe Asp Ala Ser Gln Ser Cys Asp Thr Asp Thr
            260                 265                 270         
Tyr Thr Ser Lys Thr Glu Ala Asp Asp Lys Asn Asp Glu Lys Cys Met
        275                 280                 285             
Lys Val Asp Leu Val Ser Phe Pro Ser Ser Pro Ile Met Val Asp Asn
    290                 295                 300                 
Asp Ser Ser Gly Thr Ser Asp Lys Asp His Ser Glu Ile Leu Asp Gly
305                 310                 315                 320 
Ile Ser Asn Ile Lys Leu Asn Ser Glu Glu Val Thr Gln Ser Gln Leu
                325                 330                 335     
Asp Ser Cys Thr Ser His Asp Gly His Gln Gln Leu Ser Glu Val Ser
            340                 345                 350         
Ser Lys Arg Glu Cys Pro Ala Ser Gly Gln Ser Glu Pro Arg Asn Gly
        355                 360                 365             
Gly Thr Asn Glu Glu Ser Asn Ser Ser Gly Asn Thr Asn Thr Asp Pro
    370                 375                 380                 
Pro Ala Glu Asp Ser Gln Lys Ser Ser Gly Ala Asn Thr Ser Lys Asp
385                 390                 395                 400 
Arg Pro His Ala Ser Gly Thr Asp Gly Asp Glu Ser Glu Glu Asp Pro
                405                 410                 415     
Pro Glu His Lys Pro Ser Lys Leu Lys Arg Ser His Glu Leu Asp Ile
            420                 425                 430         
Asp Glu Asn Pro Ala Ser Asp Phe Asp Asp Ser Gly Ser Leu Leu Gly
        435                 440                 445             
Phe Lys Tyr Gly Ser Gly Gln Lys Tyr Gly Gly Ile Pro Asn Phe Ser
    450                 455                 460                 
His Arg Gln Val Arg Tyr Leu Glu Lys Asn Val Lys Leu Lys Ser Lys
465                 470                 475                 480 
Tyr Leu Asp Met Arg Arg Gln Ile Lys Met Lys Asn Lys His Ile Phe
                485                 490                 495     
Phe Thr Lys Glu Ser Glu Lys Pro Phe Phe Lys Lys Ser Lys Ile Leu
            500                 505                 510         
Ser Lys Val Glu Lys Phe Leu Thr Trp Val Asn Lys Pro Met Asp Glu
        515                 520                 525             
Glu Ala Ser Gln Glu Ser Ser Ser His Asp Asn Val His Asp Ala Ser
    530                 535                 540                 
Thr Ser Ser Asp Ser Glu Glu Gln Asp Met Ser Val Lys Lys Gly Asp
545                 550                 555                 560 
Asp Leu Leu Glu Thr Asn Asn Pro Glu Pro Glu Lys Cys Gln Ser Val
                565                 570                 575     
Ser Ser Ala Gly Glu Leu Glu Thr Glu Asn Tyr Glu Arg Asp Ser Leu
            580                 585                 590         
Leu Ala Thr Val Pro Asp Glu Gln Asp Cys Val Thr Gln Glu Val Pro
        595                 600                 605             
Asp Ser Arg Gln Ala Glu Thr Glu Ala Glu Val Lys Lys Lys Lys Thr
    610                 615                 620                 
Lys Lys Lys Thr Lys Lys Val Asn Gly Leu Pro Pro Glu Ile Ala Ala
625                 630                 635                 640 
Val Pro Glu Leu Ala Lys Tyr Trp Ala Gln Arg Tyr Arg Leu Phe Ser
                645                 650                 655     
Arg Phe Asp Asp Gly Ile Lys Leu Asp Arg Glu Gly Trp Phe Ser Val
            660                 665                 670         
Thr Pro Glu Lys Ile Ala Glu His Ile Ala Gly Arg Val Ser Gln Ser
        675                 680                 685             
Phe Lys Cys Asp Val Val Val Asp Ala Phe Cys Gly Val Gly Gly Asn
    690                 695                 700                 
Thr Ile Gln Phe Ala Leu Thr Gly Met Arg Val Ile Ala Ile Asp Ile
705                 710                 715                 720 
Asp Pro Val Lys Ile Ala Leu Ala Arg Asn Asn Ala Glu Val Tyr Gly
                725                 730                 735     
Ile Ala Asp Lys Ile Glu Phe Ile Cys Gly Asp Phe Leu Leu Leu Ala
            740                 745                 750         
Ser Phe Leu Lys Ala Asp Val Val Phe Leu Ser Pro Pro Trp Gly Gly
        755                 760                 765             
Pro Asp Tyr Ala Thr Ala Glu Thr Phe Asp Ile Arg Thr Met Met Ser
    770                 775                 780                 
Pro Asp Gly Phe Glu Ile Phe Arg Leu Ser Lys Lys Ile Thr Asn Asn
785                 790                 795                 800 
Ile Val Tyr Phe Leu Pro Arg Asn Ala Asp Ile Asp Gln Val Ala Ser
                805                 810                 815     
Leu Ala Gly Pro Gly Gly Gln Val Glu Ile Glu Gln Asn Phe Leu Asn
            820                 825                 830         
Asn Lys Leu Lys Thr Ile Thr Ala Tyr Phe Gly Asp Leu Ile Arg Arg
        835                 840                 845             
Pro Ala Ser Glu Thr
    850             


<210> 7338
<211> 853
<212> PRT
<213> Homo sapiens

<400> 7338
Met Cys Cys Glu Lys Trp Ser Arg Val Ala Glu Met Phe Leu Phe Thr
 1               5                  10                  15      
Glu Glu Arg Glu Asp Cys Lys Ile Leu Cys Leu Cys Ser Arg Ala Phe
            20                  25                  30          
Val Glu Asp Arg Lys Leu Tyr Asn Leu Gly Leu Lys Gly Tyr Tyr Ile
        35                  40                  45              
Arg Asp Ser Gly Asn Asn Ser Gly Asp Gln Ala Thr Glu Glu Glu Glu
    50                  55                  60                  
Gly Gly Tyr Ser Cys Gly Thr Ala Glu Ser His Asp Ser Lys Gly Ile
65                  70                  75                  80  
Gly Leu Asp Glu Ser Glu Leu Asp Ser Glu Ala Glu Leu Met Arg Ser
                85                  90                  95      
Met Gly Leu Pro Leu Gln Phe Gly Arg Ile Thr Ala His Lys Asp Phe
            100                 105                 110         
Glu Val Ser Met Asn Thr Arg Asn Lys Val Lys Ile Lys Lys Lys Lys
        115                 120                 125             
His Gln Lys Lys Tyr Leu Asp Glu Ile Val Gln Glu Ser Trp Arg Lys
    130                 135                 140                 
Glu Tyr Glu Glu Asp Asp Ile Leu Ala Ser Asp Asp Pro Ser Ser Ile
145                 150                 155                 160 
Glu Gln Tyr Glu Asn Thr Arg Thr Tyr Glu Leu Gln Ser Lys Lys Asp
                165                 170                 175     
Thr Glu Thr Glu Asn Pro Pro Val Glu Asn Thr Leu Ser Pro Lys Leu
            180                 185                 190         
Glu Ile Thr Glu Lys Trp Glu Lys Tyr Trp Asn Glu Tyr Gly Gly Gly
        195                 200                 205             
Leu Leu Trp Gln Ser Trp Gln Glu Lys His Pro Gly Gln Ala Leu Ser
    210                 215                 220                 
Ser Glu Pro Trp Asn Phe Pro Asp Thr Lys Glu Glu Trp Glu Gln His
225                 230                 235                 240 
Tyr Ser Gln Leu Tyr Trp Tyr Tyr Leu Glu Gln Phe Gln Tyr Trp Glu
                245                 250                 255     
Ala Gln Gly Trp Thr Phe Asp Ala Ser Gln Ser Cys Asp Thr Asp Thr
            260                 265                 270         
Tyr Thr Ser Lys Thr Glu Ala Asp Asp Lys Asn Asp Glu Lys Cys Met
        275                 280                 285             
Lys Val Asp Leu Val Ser Phe Pro Ser Ser Pro Ile Met Val Asp Asn
    290                 295                 300                 
Asp Ser Ser Gly Thr Ser Asp Lys Asp His Ser Glu Ile Leu Asp Gly
305                 310                 315                 320 
Ile Ser Asn Ile Lys Leu Asn Ser Glu Glu Val Thr Gln Ser Gln Leu
                325                 330                 335     
Asp Ser Cys Thr Ser His Asp Gly His Gln Gln Leu Ser Glu Val Ser
            340                 345                 350         
Ser Lys Arg Glu Cys Pro Ala Ser Gly Gln Ser Glu Pro Arg Asn Gly
        355                 360                 365             
Gly Thr Asn Glu Glu Ser Asn Ser Ser Gly Asn Thr Asn Thr Asp Pro
    370                 375                 380                 
Pro Ala Glu Asp Ser Gln Lys Ser Ser Gly Ala Asn Thr Ser Lys Asp
385                 390                 395                 400 
Arg Pro His Ala Ser Gly Thr Asp Gly Asp Glu Ser Glu Glu Asp Pro
                405                 410                 415     
Pro Glu His Lys Pro Ser Lys Leu Lys Arg Ser His Glu Leu Asp Ile
            420                 425                 430         
Asp Glu Asn Pro Ala Ser Asp Phe Asp Asp Ser Gly Ser Leu Leu Gly
        435                 440                 445             
Phe Lys Tyr Gly Ser Gly Gln Lys Tyr Gly Gly Ile Pro Asn Phe Ser
    450                 455                 460                 
His Arg Gln Val Arg Tyr Leu Glu Lys Asn Val Lys Leu Lys Ser Lys
465                 470                 475                 480 
Tyr Leu Asp Met Arg Arg Gln Ile Lys Met Lys Asn Lys His Ile Phe
                485                 490                 495     
Phe Thr Lys Glu Ser Glu Lys Pro Phe Phe Lys Lys Ser Lys Ile Leu
            500                 505                 510         
Ser Lys Val Glu Lys Phe Leu Thr Trp Val Asn Lys Pro Met Asp Glu
        515                 520                 525             
Glu Ala Ser Gln Glu Ser Ser Ser His Asp Asn Val His Asp Ala Ser
    530                 535                 540                 
Thr Ser Ser Asp Ser Glu Glu Gln Asp Met Ser Val Lys Lys Gly Asp
545                 550                 555                 560 
Asp Leu Leu Glu Thr Asn Asn Pro Glu Pro Glu Lys Cys Gln Ser Val
                565                 570                 575     
Ser Ser Ala Gly Glu Leu Glu Thr Glu Asn Tyr Glu Arg Asp Ser Leu
            580                 585                 590         
Leu Ala Thr Val Pro Asp Glu Gln Asp Cys Val Thr Gln Glu Val Pro
        595                 600                 605             
Asp Ser Arg Gln Ala Glu Thr Glu Ala Glu Val Lys Lys Lys Lys Asn
    610                 615                 620                 
Lys Lys Lys Asn Lys Lys Val Asn Gly Leu Pro Pro Glu Ile Ala Ala
625                 630                 635                 640 
Val Pro Glu Leu Ala Lys Tyr Trp Ala Gln Arg Tyr Arg Leu Phe Ser
                645                 650                 655     
Arg Phe Asp Asp Gly Ile Lys Leu Asp Arg Glu Gly Trp Phe Ser Val
            660                 665                 670         
Thr Pro Glu Lys Ile Ala Glu His Ile Ala Gly Arg Val Ser Gln Ser
        675                 680                 685             
Phe Lys Cys Asp Val Val Val Asp Ala Phe Cys Gly Val Gly Gly Asn
    690                 695                 700                 
Thr Ile Gln Phe Ala Leu Thr Gly Met Arg Val Ile Ala Ile Asp Ile
705                 710                 715                 720 
Asp Pro Val Lys Ile Ala Leu Ala Arg Asn Asn Ala Glu Val Tyr Gly
                725                 730                 735     
Ile Ala Asp Lys Ile Glu Phe Ile Cys Gly Asp Phe Leu Leu Leu Ala
            740                 745                 750         
Ser Phe Leu Lys Ala Asp Val Val Phe Leu Ser Pro Pro Trp Gly Gly
        755                 760                 765             
Pro Asp His Ala Thr Ala Glu Thr Phe Asp Ile Arg Thr Met Met Ser
    770                 775                 780                 
Pro Asp Gly Phe Glu Ile Phe Arg Leu Ser Lys Lys Ile Thr Asn Asn
785                 790                 795                 800 
Ile Val Tyr Phe Leu Pro Arg Asn Ala Asp Ile Asp Gln Val Ala Ser
                805                 810                 815     
Leu Ala Gly Pro Gly Gly Gln Val Glu Ile Glu Gln Asn Phe Leu Asn
            820                 825                 830         
Asn Lys Leu Lys Thr Ile Thr Ala Tyr Phe Gly Asp Leu Ile Arg Arg
        835                 840                 845             
Pro Ala Ser Glu Thr
    850             


<210> 7339
<211> 1663
<212> PRT
<213> Homo sapiens

<400> 7339
Met Thr Asp Arg Phe Trp Asp Gln Trp Tyr Leu Trp Tyr Leu Arg Leu
 1               5                  10                  15      
Leu Arg Leu Leu Asp Arg Gly Ser Phe Arg Asn Asp Gly Leu Lys Ala
            20                  25                  30          
Ser Asp Val Leu Pro Ile Leu Lys Glu Lys Val Ala Phe Val Ser Gly
        35                  40                  45              
Gly Arg Asp Lys Arg Gly Gly Pro Ile Leu Thr Phe Pro Ala Arg Ser
    50                  55                  60                  
Asn His Asp Arg Ile Arg Gln Glu Asp Leu Arg Lys Leu Val Thr Tyr
65                  70                  75                  80  
Leu Ala Ser Val Pro Ser Glu Asp Val Cys Lys Arg Gly Phe Thr Val
                85                  90                  95      
Ile Ile Asp Met Arg Gly Ser Lys Trp Asp Leu Ile Lys Pro Leu Leu
            100                 105                 110         
Lys Thr Leu Gln Glu Ala Phe Pro Ala Glu Ile His Val Ala Leu Ile
        115                 120                 125             
Ile Lys Pro Asp Asn Phe Trp Gln Lys Gln Lys Thr Asn Phe Gly Ser
    130                 135                 140                 
Ser Lys Phe Ile Phe Glu Thr Ser Met Val Ser Val Glu Gly Leu Thr
145                 150                 155                 160 
Lys Leu Val Asp Pro Ser Gln Leu Thr Glu Glu Phe Asp Gly Ser Leu
                165                 170                 175     
Asp Tyr Asn His Glu Glu Trp Ile Glu Leu Arg Leu Ser Leu Glu Glu
            180                 185                 190         
Phe Phe Asn Ser Ala Val His Leu Leu Ser Arg Leu Glu Asp Leu Gln
        195                 200                 205             
Glu Met Leu Ala Arg Lys Glu Phe Pro Val Asp Val Glu Gly Ser Arg
    210                 215                 220                 
Arg Leu Ile Asp Glu His Thr Gln Leu Lys Lys Lys Val Leu Lys Ala
225                 230                 235                 240 
Pro Val Glu Glu Leu Asp Arg Glu Gly Gln Arg Leu Leu Gln Cys Ile
                245                 250                 255     
Arg Cys Ser Asp Gly Phe Ser Gly Arg Asn Cys Ile Pro Gly Ser Ala
            260                 265                 270         
Asp Phe Gln Ser Leu Val Pro Lys Ile Thr Ser Leu Leu Asp Lys Leu
        275                 280                 285             
His Ser Thr Arg Gln His Leu His Gln Met Trp His Val Arg Lys Leu
    290                 295                 300                 
Lys Leu Asp Gln Cys Phe Gln Leu Arg Leu Phe Glu Gln Asp Ala Glu
305                 310                 315                 320 
Lys Met Phe Asp Trp Ile Ser His Asn Lys Glu Leu Phe Leu Gln Ser
                325                 330                 335     
His Thr Glu Ile Gly Val Ser Tyr Gln Tyr Ala Leu Asp Leu Gln Thr
            340                 345                 350         
Gln His Asn His Phe Ala Met Asn Ser Met Asn Ala Tyr Val Asn Ile
        355                 360                 365             
Asn Arg Ile Met Ser Val Ala Ser Arg Leu Ser Glu Ala Gly His Tyr
    370                 375                 380                 
Ala Ser Gln Gln Ile Lys Gln Ile Ser Thr Gln Leu Asp Gln Glu Trp
385                 390                 395                 400 
Lys Ser Phe Ala Ala Ala Leu Asp Glu Arg Ser Thr Ile Leu Ala Met
                405                 410                 415     
Ser Ala Val Phe His Gln Lys Ala Glu Gln Phe Leu Ser Gly Val Asp
            420                 425                 430         
Ala Trp Cys Lys Met Cys Ser Glu Gly Gly Leu Pro Ser Glu Met Gln
        435                 440                 445             
Asp Leu Glu Leu Ala Ile His His His Gln Thr Leu Tyr Glu Gln Val
    450                 455                 460                 
Thr Gln Ala Tyr Thr Glu Val Ser Gln Asp Gly Lys Ala Leu Leu Asp
465                 470                 475                 480 
Val Leu Gln Arg Pro Leu Ser Pro Gly Asn Ser Glu Ser Leu Thr Ala
                485                 490                 495     
Thr Ala Asn Tyr Ser Lys Ala Val His Gln Val Leu Asp Val Val His
            500                 505                 510         
Glu Val Leu His His Gln Arg Arg Leu Glu Ser Ile Trp Gln His Arg
        515                 520                 525             
Lys Val Arg Leu His Gln Arg Leu Gln Leu Cys Val Phe Gln Gln Asp
    530                 535                 540                 
Val Gln Gln Val Leu Asp Trp Ile Glu Asn His Gly Glu Ala Phe Leu
545                 550                 555                 560 
Ser Lys His Thr Gly Val Gly Lys Ser Leu His Arg Ala Arg Ala Leu
                565                 570                 575     
Gln Lys Arg His Asp Asp Phe Glu Glu Val Ala Gln Asn Thr Tyr Thr
            580                 585                 590         
Asn Ala Asp Lys Leu Leu Glu Ala Ala Glu Gln Leu Ala Gln Thr Gly
        595                 600                 605             
Glu Cys Asp Pro Glu Glu Ile Tyr Lys Ala Ala Arg His Leu Glu Val
    610                 615                 620                 
Arg Ile Gln Asp Phe Val Arg Arg Val Glu Gln Arg Lys Leu Leu Leu
625                 630                 635                 640 
Asp Met Ser Val Ser Phe His Thr His Thr Lys Glu Leu Trp Thr Trp
                645                 650                 655     
Met Glu Asp Leu Gln Lys Glu Met Leu Glu Asp Val Cys Ala Asp Ser
            660                 665                 670         
Val Asp Ala Val Gln Glu Leu Ile Lys Gln Phe Gln Gln Gln Gln Thr
        675                 680                 685             
Ala Thr Leu Asp Ala Thr Leu Asn Val Ile Lys Glu Gly Glu Asp Leu
    690                 695                 700                 
Ile Gln Gln Leu Arg Ser Ala Pro Pro Ser Leu Gly Glu Pro Ser Glu
705                 710                 715                 720 
Ala Arg Asp Ser Ala Val Ser Asn Asn Lys Thr Pro His Ser Ser Ser
                725                 730                 735     
Ile Ser His Ile Glu Ser Val Leu Gln Gln Leu Asp Asp Ala Gln Val
            740                 745                 750         
Gln Met Glu Glu Leu Phe His Glu Arg Lys Ile Lys Leu Asp Ile Phe
        755                 760                 765             
Leu Gln Leu Arg Ile Phe Glu Gln Tyr Thr Ile Glu Val Thr Ala Glu
    770                 775                 780                 
Leu Asp Ala Trp Asn Glu Asp Leu Leu Arg Gln Met Asn Asp Phe Asn
785                 790                 795                 800 
Thr Glu Asp Leu Thr Leu Ala Glu Gln Arg Leu Gln Arg His Thr Glu
                805                 810                 815     
Arg Lys Leu Ala Met Asn Asn Met Thr Phe Glu Val Ile Gln Gln Gly
            820                 825                 830         
Gln Asp Leu His Gln Tyr Ile Thr Glu Val Gln Ala Ser Gly Ile Glu
        835                 840                 845             
Leu Ile Cys Glu Lys Asp Ile Asp Leu Ala Ala Gln Val Gln Glu Leu
    850                 855                 860                 
Leu Glu Phe Leu His Glu Lys Gln His Glu Leu Glu Leu Asn Ala Glu
865                 870                 875                 880 
Gln Thr His Lys Arg Leu Glu Gln Cys Leu Gln Leu Arg His Leu Gln
                885                 890                 895     
Ala Glu Val Lys Gln Val Leu Gly Trp Ile Arg Asn Gly Glu Ser Met
            900                 905                 910         
Leu Asn Ala Ser Leu Val Asn Ala Ser Ser Leu Ser Glu Ala Glu Gln
        915                 920                 925             
Leu Gln Arg Glu His Glu Gln Phe Gln Leu Ala Ile Glu Ser Leu Phe
    930                 935                 940                 
His Ala Thr Ser Leu Gln Lys Thr His Gln Ser Ala Leu Gln Val Gln
945                 950                 955                 960 
Gln Lys Ala Glu Val Leu Leu Gln Ala Gly His Tyr Asp Ala Asp Ala
                965                 970                 975     
Ile Arg Glu Cys Ala Glu Lys Val Ala Leu His Trp Gln Gln Leu Met
            980                 985                 990         
Leu Lys Met Glu Asp Arg Leu Lys Leu Val Asn Ala Ser Val Ala Phe
        995                 1000                1005            
Tyr Lys Thr Ser Glu Gln Val Cys Ser Val Leu Glu Ser Leu Glu Gln
    1010                1015                1020                
Glu Tyr Arg Arg Asp Glu Asp Trp Cys Gly Gly Arg Asp Lys Leu Gly
1025                1030                1035                1040
Pro Ala Ala Glu Ile Asp His Val Ile Pro Leu Ile Ser Lys His Leu
                1045                1050                1055    
Glu Gln Lys Glu Ala Phe Leu Lys Ala Cys Thr Leu Ala Arg Arg Asn
            1060                1065                1070        
Ala Glu Val Phe Leu Lys Tyr Ile His Arg Asn Asn Val Ser Met Pro
        1075                1080                1085            
Ser Val Ala Ser His Thr Arg Gly Pro Glu Gln Gln Val Lys Ala Ile
    1090                1095                1100                
Leu Ser Glu Leu Leu Gln Arg Glu Asn Arg Val Leu His Phe Trp Thr
1105                1110                1115                1120
Leu Lys Lys Arg Arg Leu Asp Gln Cys Gln Gln Tyr Val Val Phe Glu
                1125                1130                1135    
Arg Ser Ala Lys Gln Ala Leu Asp Trp Ile Gln Glu Thr Gly Glu Phe
            1140                1145                1150        
Tyr Leu Ser Thr His Thr Ser Thr Gly Glu Thr Thr Glu Glu Thr Gln
        1155                1160                1165            
Glu Leu Leu Lys Glu Tyr Gly Glu Phe Arg Val Pro Ala Lys Gln Thr
    1170                1175                1180                
Lys Glu Lys Val Lys Leu Leu Ile Gln Leu Ala Asp Ser Phe Val Glu
1185                1190                1195                1200
Lys Gly His Ile His Ala Thr Glu Ile Arg Lys Trp Val Thr Thr Val
                1205                1210                1215    
Asp Lys His Tyr Arg Asp Phe Ser Leu Arg Met Gly Lys Tyr Arg Tyr
            1220                1225                1230        
Ser Leu Glu Lys Ala Leu Gly Val Asn Thr Glu Asp Asn Lys Asp Leu
        1235                1240                1245            
Glu Leu Asp Ile Ile Pro Ala Ser Leu Ser Asp Arg Glu Val Lys Leu
    1250                1255                1260                
Arg Asp Ala Asn His Glu Val Asn Glu Glu Lys Arg Lys Ser Ala Arg
1265                1270                1275                1280
Lys Lys Glu Phe Ile Met Ala Glu Leu Leu Gln Thr Glu Lys Ala Tyr
                1285                1290                1295    
Val Arg Asp Leu His Glu Cys Leu Glu Thr Tyr Leu Trp Glu Met Thr
            1300                1305                1310        
Ser Gly Val Glu Glu Ile Pro Pro Gly Ile Leu Asn Lys Glu His Ile
        1315                1320                1325            
Ile Phe Gly Asn Ile Gln Glu Ile Tyr Asp Phe His Asn Asn Ile Phe
    1330                1335                1340                
Leu Lys Glu Leu Glu Lys Tyr Glu Gln Leu Pro Glu Asp Val Gly His
1345                1350                1355                1360
Cys Phe Val Thr Trp Ala Asp Lys Phe Gln Met Tyr Val Thr Tyr Cys
                1365                1370                1375    
Lys Asn Lys Pro Asp Ser Asn Gln Leu Ile Leu Glu His Ala Gly Thr
            1380                1385                1390        
Phe Phe Asp Glu Ile Gln Gln Arg His Gly Leu Ala Asn Ser Ile Ser
        1395                1400                1405            
Ser Tyr Leu Ile Lys Pro Val Gln Arg Ile Thr Lys Tyr Gln Leu Leu
    1410                1415                1420                
Leu Lys Glu Leu Leu Thr Cys Cys Glu Glu Gly Lys Gly Glu Leu Lys
1425                1430                1435                1440
Asp Gly Leu Glu Val Met Leu Ser Val Pro Lys Lys Ala Asn Asp Ala
                1445                1450                1455    
Met His Val Ser Met Leu Glu Gly Phe Asp Glu Asn Leu Asp Val Gln
            1460                1465                1470        
Gly Glu Leu Ile Leu Gln Asp Ala Phe Gln Val Trp Asp Pro Lys Ser
        1475                1480                1485            
Leu Ile Arg Lys Gly Arg Glu Arg His Leu Phe Leu Phe Glu Ile Ser
    1490                1495                1500                
Leu Val Phe Ser Lys Glu Ile Lys Asp Ser Ser Gly His Thr Lys Tyr
1505                1510                1515                1520
Val Tyr Lys Asn Lys Leu Leu Thr Ser Glu Leu Gly Val Thr Glu His
                1525                1530                1535    
Val Glu Gly Asp Pro Cys Lys Phe Ala Leu Trp Ser Gly Arg Thr Pro
            1540                1545                1550        
Ser Ser Asp Asn Lys Thr Val Leu Lys Ala Ser Asn Ile Glu Thr Lys
        1555                1560                1565            
Gln Glu Trp Ile Lys Asn Ile Arg Glu Val Ile Gln Glu Arg Ile Ile
    1570                1575                1580                
His Leu Lys Gly Ala Leu Lys Glu Pro Leu Gln Leu Pro Lys Thr Pro
1585                1590                1595                1600
Ala Lys Gln Arg Asn Asn Ser Lys Arg Asp Gly Val Glu Asp Ile Asp
                1605                1610                1615    
Ser Gln Gly Asp Gly Ser Ser Gln Pro Asp Thr Ile Ser Ile Ala Ser
            1620                1625                1630        
Arg Thr Ser Gln Asn Thr Val Asp Ser Asp Lys Asp Gly Asn Leu Val
        1635                1640                1645            
Pro Arg Trp His Leu Gly Pro Gly Asp Pro Phe Ser Thr Tyr Val
    1650                1655                1660            


<210> 7340
<211> 723
<212> PRT
<213> Homo sapiens

<400> 7340
Met Pro Ser Gly Thr Glu Gln Gln Thr Glu Gly Thr Ser Val Thr Phe
 1               5                  10                  15      
Ser Pro Leu Lys Ser Pro Pro Gln Leu Glu Arg Glu Met Ala Ser Pro
            20                  25                  30          
Pro Glu Cys Ser Glu Met Pro Leu Asp Leu Ser Ser Lys Ser Asn Arg
        35                  40                  45              
Gln Lys Leu Pro Leu Pro Asn Gln Arg Lys Thr Pro Pro Met Pro Val
    50                  55                  60                  
Leu Thr Pro Val His Thr Ser Ser Lys Ala Leu Leu Ser Thr Val Leu
65                  70                  75                  80  
Ser Arg Ser Gln Arg Thr Thr Gln Ala Ala Gly Gly Asn Val Thr Ser
                85                  90                  95      
Cys Leu Gly Ser Thr Ser Ser Pro Phe Val Ile Phe Pro Glu Ile Val
            100                 105                 110         
Arg Asn Gly Asp Pro Ser Thr Trp Val Lys Asn Ser Thr Ala Leu Ile
        115                 120                 125             
Ser Thr Ile Pro Gly Thr Tyr Val Gly Val Ala Asn Pro Val Pro Ala
    130                 135                 140                 
Ser Leu Leu Leu Asn Lys Asp Pro Asn Leu Gly Leu Asn Arg Asp Pro
145                 150                 155                 160 
Arg His Leu Pro Lys Gln Glu Pro Ile Ser Ile Ile Asp Gln Gly Glu
                165                 170                 175     
Pro Lys Gly Thr Gly Ala Thr Cys Gly Lys Lys Gly Ser Gln Ala Gly
            180                 185                 190         
Ala Glu Gly Gln Pro Ser Thr Val Lys Arg Tyr Thr Pro Ala Arg Ile
        195                 200                 205             
Ala Pro Gly Leu Pro Gly Cys Gln Thr Lys Glu Leu Ser Leu Trp Lys
    210                 215                 220                 
Pro Thr Gly Pro Ala Asn Ile Tyr Pro Arg Cys Ser Val Asn Gly Lys
225                 230                 235                 240 
Pro Thr Ser Thr Gln Val Leu Pro Val Gly Trp Ser Pro Tyr His Gln
                245                 250                 255     
Ala Ser Leu Leu Ser Ile Gly Ile Ser Ser Ala Gly Gln Leu Thr Pro
            260                 265                 270         
Ser Gln Gly Ala Pro Ile Arg Pro Thr Ser Val Val Ser Glu Phe Ser
        275                 280                 285             
Gly Val Pro Ser Leu Ser Ser Ser Glu Ala Val His Gly Leu Pro Glu
    290                 295                 300                 
Gly Gln Pro Arg Pro Gly Gly Ser Phe Val Pro Glu Gln Asp Pro Val
305                 310                 315                 320 
Thr Lys Asn Lys Thr Cys Arg Ile Ala Ala Lys Pro Tyr Glu Glu Gln
                325                 330                 335     
Val Asn Pro Val Leu Leu Thr Leu Ser Pro Gln Thr Gly Thr Leu Ala
            340                 345                 350         
Leu Ser Val Gln Pro Ser Gly Gly Asp Ile Arg Met Asn Gln Gly Pro
        355                 360                 365             
Glu Glu Ser Glu Ser His Leu Cys Ser Asp Ser Thr Pro Lys Met Glu
    370                 375                 380                 
Gly Pro Gln Gly Ala Cys Gly Leu Lys Leu Ala Gly Asp Thr Lys Pro
385                 390                 395                 400 
Lys Asn Gln Val Leu Ala Thr Tyr Met Ser His Glu Leu Val Leu Ala
                405                 410                 415     
Thr Pro Gln Asn Leu Pro Lys Met Pro Glu Leu Pro Leu Leu Pro His
            420                 425                 430         
Asp Ser His Pro Lys Glu Leu Ile Leu Asp Val Val Pro Ser Ser Arg
        435                 440                 445             
Arg Gly Ser Ser Thr Glu Arg Pro Gln Leu Gly Ser Gln Val Asp Leu
    450                 455                 460                 
Gly Arg Val Lys Met Glu Lys Val Asp Gly Asp Val Val Phe Asn Leu
465                 470                 475                 480 
Ala Thr Cys Phe Arg Ala Asp Gly Leu Pro Val Ala Pro Gln Arg Gly
                485                 490                 495     
Gln Ala Glu Val Arg Ala Lys Ala Gly Gln Ala Arg Val Lys Gln Glu
            500                 505                 510         
Ser Val Gly Val Phe Ala Cys Lys Asn Lys Trp Gln Pro Asp Asp Val
        515                 520                 525             
Thr Glu Ser Leu Pro Pro Lys Lys Met Lys Cys Gly Lys Glu Lys Asp
    530                 535                 540                 
Ser Glu Glu Gln Gln Leu Gln Pro Gln Ala Lys Ala Val Val Arg Ser
545                 550                 555                 560 
Ser His Arg Pro Lys Cys Arg Lys Leu Pro Ser Asp Pro Gln Glu Ser
                565                 570                 575     
Thr Lys Lys Ser Pro Arg Gly Ala Ser Asp Ser Gly Lys Glu His Asn
            580                 585                 590         
Gly Val Arg Gly Lys His Lys His Arg Lys Pro Thr Lys Pro Glu Ser
        595                 600                 605             
Gln Ser Pro Gly Lys Arg Ala Asp Ser His Glu Glu Gly Ser Leu Glu
    610                 615                 620                 
Lys Lys Ala Lys Ser Ser Phe Arg Asp Phe Ile Pro Val Val Leu Ser
625                 630                 635                 640 
Thr Arg Thr Arg Ser Gln Ser Asp Leu Lys Ala Arg Lys Gln Lys Thr
                645                 650                 655     
Ser Ser Ser Gln Ser Leu Glu His Arg Leu Arg Asn Arg Asn Leu Leu
            660                 665                 670         
Leu Pro Asn Lys Val Gln Gly Ile Ser Asp Ser Pro Asn Gly Phe Leu
        675                 680                 685             
Pro Asn Asn Leu Glu Glu Pro Ala Cys Leu Glu Asn Ser Glu Lys Pro
    690                 695                 700                 
Ser Gly Lys Arg Lys Cys Lys Thr Lys His Met Ala Thr Val Ser Glu
705                 710                 715                 720 
Glu Ala Lys
            


<210> 7341
<211> 1719
<212> PRT
<213> Homo sapiens

<400> 7341
Met Ile Ser Thr Ala Pro Leu Tyr Ser Gly Val His Asn Trp Thr Ser
 1               5                  10                  15      
Ser Asp Arg Ile Arg Met Cys Gly Ile Asn Glu Glu Arg Arg Ala Pro
            20                  25                  30          
Leu Ser Asp Glu Glu Ser Thr Thr Gly Asp Cys Gln His Phe Gly Ser
        35                  40                  45              
Gln Glu Phe Cys Val Ser Ser Ser Phe Ser Lys Val Glu Leu Thr Ala
    50                  55                  60                  
Val Gly Ser Gly Ser Asn Ala Arg Gly Ala Asp Pro Asp Gly Ser Ala
65                  70                  75                  80  
Thr Glu Lys Leu Gly His Lys Ser Glu Asp Lys Pro Asp Asp Pro Gln
                85                  90                  95      
Pro Lys Met Asp Tyr Ala Gly Asn Val Ala Glu Ala Glu Gly Phe Leu
            100                 105                 110         
Val Pro Leu Ser Ser Pro Gly Asp Gly Leu Lys Leu Pro Ala Ser Asp
        115                 120                 125             
Ser Ala Glu Ala Ser Asn Ser Arg Ala Asp Cys Ser Trp Thr Pro Leu
    130                 135                 140                 
Asn Thr Gln Met Ser Lys Gln Val Asp Cys Ser Pro Ala Gly Val Lys
145                 150                 155                 160 
Ala Leu Asp Ser Arg Gln Gly Val Gly Glu Lys Asn Thr Phe Ile Leu
                165                 170                 175     
Ala Thr Leu Gly Thr Gly Val Pro Val Glu Gly Thr Leu Pro Leu Val
            180                 185                 190         
Thr Thr Asn Phe Ser Pro Leu Pro Ala Pro Ile Cys Pro Pro Ala Pro
        195                 200                 205             
Gly Ser Ala Ser Val Pro His Ser Val Pro Asp Ala Phe Gln Val Pro
    210                 215                 220                 
Leu Ser Val Pro Ala Pro Val Pro His Ser Gly Leu Val Pro Val Gln
225                 230                 235                 240 
Val Ala Thr Ser Val Pro Ala Pro Ser Pro Pro Leu Ala Pro Val Pro
                245                 250                 255     
Ala Leu Ala Pro Ala Pro Pro Ser Val Pro Thr Leu Ile Ser Asp Ser
            260                 265                 270         
Asn Pro Leu Ser Val Ser Ala Ser Val Leu Val Pro Val Pro Ala Ser
        275                 280                 285             
Ala Pro Pro Ser Gly Pro Val Pro Leu Ser Ala Pro Ala Pro Ala Pro
    290                 295                 300                 
Leu Ser Val Pro Val Ser Ala Pro Pro Leu Ala Leu Ile Gln Ala Pro
305                 310                 315                 320 
Val Pro Pro Ser Ala Pro Thr Leu Val Leu Ala Pro Val Pro Thr Pro
                325                 330                 335     
Val Leu Ala Pro Met Pro Ala Ser Thr Pro Pro Ala Ala Pro Ala Pro
            340                 345                 350         
Pro Ser Val Pro Met Pro Thr Pro Thr Pro Ser Ser Gly Pro Pro Ser
        355                 360                 365             
Thr Pro Thr Leu Ile Pro Ala Phe Ala Pro Thr Pro Val Pro Ala Pro
    370                 375                 380                 
Thr Pro Ala Pro Ile Phe Thr Pro Ala Pro Thr Pro Met Pro Ala Ala
385                 390                 395                 400 
Thr Pro Ala Ala Ile Pro Thr Ser Ala Pro Ile Pro Ala Ser Phe Ser
                405                 410                 415     
Leu Ser Arg Val Cys Phe Pro Ala Ala Gln Ala Pro Ala Met Gln Lys
            420                 425                 430         
Val Pro Leu Ser Phe Gln Pro Gly Thr Val Leu Thr Pro Ser Gln Pro
        435                 440                 445             
Leu Val Tyr Ile Pro Pro Pro Ser Cys Gly Gln Pro Leu Ser Val Ala
    450                 455                 460                 
Thr Leu Pro Thr Thr Leu Gly Val Ser Ser Thr Leu Thr Leu Pro Val
465                 470                 475                 480 
Leu Pro Ser Tyr Leu Gln Asp Arg Cys Leu Pro Gly Val Leu Ala Ser
                485                 490                 495     
Pro Glu Leu Arg Ser Tyr Pro Tyr Ala Phe Ser Val Ala Arg Pro Leu
            500                 505                 510         
Thr Ser Asp Ser Lys Leu Val Ser Leu Glu Val Asn Arg Leu Pro Cys
        515                 520                 525             
Thr Ser Pro Ser Gly Ser Thr Thr Thr Gln Pro Ala Pro Asp Gly Val
    530                 535                 540                 
Pro Gly Pro Leu Ala Asp Thr Ser Leu Val Thr Ala Ser Ala Lys Val
545                 550                 555                 560 
Leu Pro Thr Pro Gln Pro Leu Leu Pro Ala Pro Ser Gly Ser Ser Ala
                565                 570                 575     
Pro Pro His Pro Ala Lys Met Pro Ser Gly Thr Glu Gln Gln Thr Glu
            580                 585                 590         
Gly Thr Ser Val Thr Phe Ser Pro Leu Lys Ser Pro Pro Gln Leu Glu
        595                 600                 605             
Arg Glu Met Ala Ser Pro Pro Glu Cys Ser Glu Met Pro Leu Asp Leu
    610                 615                 620                 
Ser Ser Lys Ser Asn Arg Gln Lys Leu Pro Leu Pro Asn Gln Arg Lys
625                 630                 635                 640 
Thr Pro Pro Met Pro Val Leu Thr Pro Val His Thr Ser Ser Lys Ala
                645                 650                 655     
Leu Leu Ser Thr Val Leu Ser Arg Ser Gln Arg Thr Thr Gln Ala Ala
            660                 665                 670         
Gly Gly Asn Val Thr Ser Cys Leu Gly Ser Thr Ser Ser Pro Phe Val
        675                 680                 685             
Ile Phe Pro Glu Ile Val Arg Asn Gly Asp Pro Ser Thr Trp Val Lys
    690                 695                 700                 
Asn Ser Thr Ala Leu Ile Ser Thr Ile Pro Gly Thr Tyr Val Gly Val
705                 710                 715                 720 
Ala Asn Pro Val Pro Ala Ser Leu Leu Leu Asn Lys Asp Pro Asn Leu
                725                 730                 735     
Gly Leu Asn Arg Asp Pro Arg His Leu Pro Lys Gln Glu Pro Ile Ser
            740                 745                 750         
Ile Ile Asp Gln Gly Glu Pro Lys Gly Thr Gly Ala Thr Cys Gly Lys
        755                 760                 765             
Lys Gly Ser Gln Ala Gly Ala Glu Gly Gln Pro Ser Thr Val Lys Arg
    770                 775                 780                 
Tyr Thr Pro Ala Arg Ile Ala Pro Gly Leu Pro Gly Cys Gln Thr Lys
785                 790                 795                 800 
Glu Leu Ser Leu Trp Lys Pro Thr Gly Pro Ala Asn Ile Tyr Pro Arg
                805                 810                 815     
Cys Ser Val Asn Gly Lys Pro Thr Ser Thr Gln Val Leu Pro Val Gly
            820                 825                 830         
Trp Ser Pro Tyr His Gln Ala Ser Leu Leu Ser Ile Gly Ile Ser Ser
        835                 840                 845             
Ala Gly Gln Leu Thr Pro Ser Gln Gly Ala Pro Ile Arg Pro Thr Ser
    850                 855                 860                 
Val Val Ser Glu Phe Ser Gly Val Pro Ser Leu Ser Ser Ser Glu Ala
865                 870                 875                 880 
Val His Gly Leu Pro Glu Gly Gln Pro Arg Pro Gly Gly Ser Phe Val
                885                 890                 895     
Pro Glu Gln Asp Pro Val Thr Lys Asn Lys Thr Cys Arg Ile Ala Ala
            900                 905                 910         
Lys Pro Tyr Glu Glu Gln Val Asn Pro Val Leu Leu Thr Leu Ser Pro
        915                 920                 925             
Gln Thr Gly Thr Leu Ala Leu Ser Val Gln Pro Ser Gly Gly Asp Ile
    930                 935                 940                 
Arg Met Asn Gln Gly Pro Glu Glu Ser Glu Ser His Leu Cys Ser Asp
945                 950                 955                 960 
Ser Thr Pro Lys Met Glu Gly Pro Gln Gly Ala Cys Gly Leu Lys Leu
                965                 970                 975     
Ala Gly Asp Thr Lys Pro Lys Asn Gln Val Leu Ala Thr Tyr Met Ser
            980                 985                 990         
His Glu Leu Val Leu Ala Thr Pro Gln Asn Leu Pro Lys Met Pro Glu
        995                 1000                1005            
Leu Pro Leu Leu Pro His Asp Ser His Pro Lys Glu Leu Ile Leu Asp
    1010                1015                1020                
Val Val Pro Ser Ser Arg Arg Gly Ser Ser Thr Glu Arg Pro Gln Leu
1025                1030                1035                1040
Gly Ser Gln Val Asp Leu Gly Arg Val Lys Met Glu Lys Val Asp Gly
                1045                1050                1055    
Asp Val Val Phe Asn Leu Ala Thr Cys Phe Arg Ala Asp Gly Leu Pro
            1060                1065                1070        
Val Ala Pro Gln Arg Gly Gln Ala Glu Val Arg Ala Lys Ala Gly Gln
        1075                1080                1085            
Ala Arg Val Lys Gln Glu Ser Val Gly Val Phe Ala Cys Lys Asn Lys
    1090                1095                1100                
Trp Gln Pro Asp Asp Val Thr Glu Ser Leu Pro Pro Lys Lys Met Lys
1105                1110                1115                1120
Cys Gly Lys Glu Lys Asp Ser Glu Glu Gln Gln Leu Gln Pro Gln Ala
                1125                1130                1135    
Lys Ala Val Val Arg Ser Ser His Arg Pro Lys Cys Arg Lys Leu Pro
            1140                1145                1150        
Ser Asp Pro Gln Glu Ser Thr Lys Lys Ser Pro Arg Gly Ala Ser Asp
        1155                1160                1165            
Ser Gly Lys Glu His Asn Gly Val Arg Gly Lys His Lys His Arg Lys
    1170                1175                1180                
Pro Thr Lys Pro Glu Ser Gln Ser Pro Gly Lys Arg Ala Asp Ser His
1185                1190                1195                1200
Glu Glu Gly Ser Leu Glu Lys Lys Ala Lys Ser Ser Phe Arg Asp Phe
                1205                1210                1215    
Ile Pro Val Val Leu Ser Thr Arg Thr Arg Ser Gln Ser Gly Ser Ile
            1220                1225                1230        
Cys Ser Ser Phe Ala Gly Met Ala Asp Ser Asp Met Gly Ser Gln Glu
        1235                1240                1245            
Val Phe Pro Thr Glu Glu Glu Glu Glu Val Thr Pro Thr Pro Ala Lys
    1250                1255                1260                
Arg Arg Lys Val Arg Lys Thr Gln Arg Asp Thr Gln Tyr Arg Ser His
1265                1270                1275                1280
His Ala Gln Asp Lys Ser Leu Leu Ser Gln Gly Arg Arg His Leu Trp
                1285                1290                1295    
Arg Ala Arg Glu Met Pro Trp Arg Thr Glu Ala Ala Arg Gln Met Trp
            1300                1305                1310        
Asp Thr Asn Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Leu Leu Lys
        1315                1320                1325            
Arg Lys Lys Arg Arg Arg Gln Lys Ser Arg Lys Tyr Gln Thr Gly Glu
    1330                1335                1340                
Tyr Leu Thr Glu Gln Glu Asp Glu Gln Arg Arg Lys Gly Arg Ala Asp
1345                1350                1355                1360
Leu Lys Ala Arg Lys Gln Lys Thr Ser Ser Ser Gln Ser Leu Glu His
                1365                1370                1375    
Arg Leu Arg Asn Arg Asn Leu Leu Leu Pro Asn Lys Val Gln Gly Ile
            1380                1385                1390        
Ser Asp Ser Pro Asn Gly Phe Leu Pro Asn Asn Leu Glu Glu Pro Ala
        1395                1400                1405            
Cys Leu Glu Asn Ser Glu Lys Pro Ser Gly Lys Arg Lys Cys Lys Thr
    1410                1415                1420                
Lys His Met Ala Thr Val Ser Glu Glu Ala Lys Asp Val Val Leu Tyr
1425                1430                1435                1440
Cys Leu Gln Lys Asp Ser Glu Asp Val Asn His Arg Asp Asn Ala Gly
                1445                1450                1455    
Tyr Thr Ala Leu His Glu Ala Cys Ser Arg Gly Trp Thr Asp Ile Leu
            1460                1465                1470        
Asn Ile Leu Leu Glu His Gly Ala Asn Val Asn Cys Ser Ala Gln Asp
        1475                1480                1485            
Gly Thr Arg Gln Glu Gly Cys Ile Ser Pro Gln Pro Val His Asp Ala
    1490                1495                1500                
Val Val Asn Asp Asn Leu Glu Thr Ile Trp Leu Leu Leu Ser Tyr Gly
1505                1510                1515                1520
Ala Asp Pro Thr Leu Ala Thr Tyr Ser Gly Gln Thr Ala Met Lys Leu
                1525                1530                1535    
Ala Ser Ser Asp Thr Met Lys Arg Phe Leu Ser Asp His Leu Ser Asp
            1540                1545                1550        
Leu Gln Gly Arg Ala Glu Gly Asp Pro Gly Val Ser Trp Asp Phe Tyr
        1555                1560                1565            
Ser Ser Ser Val Leu Glu Glu Lys Asp Gly Phe Ala Cys Asp Leu Leu
    1570                1575                1580                
His Asn Pro Pro Gly Ser Ser Asp Gln Glu Gly Asp Asp Pro Met Glu
1585                1590                1595                1600
Glu Asp Asp Phe Met Phe Glu Leu Ser Asp Lys Pro Leu Leu Pro Cys
                1605                1610                1615    
Tyr Asn Leu Gln Val Ser Val Ser Arg Gly Pro Cys Asn Trp Phe Leu
            1620                1625                1630        
Phe Ser Asp Val Leu Lys Arg Leu Lys Leu Ser Ser Arg Ile Phe Gln
        1635                1640                1645            
Ala Arg Phe Pro His Phe Glu Ile Thr Thr Met Pro Lys Ala Glu Phe
    1650                1655                1660                
Tyr Arg Gln Val Ala Ser Ser Gln Leu Leu Thr Pro Ala Glu Arg Pro
1665                1670                1675                1680
Gly Gly Leu Asp Asp Arg Ser Pro Pro Gly Ser Ser Glu Thr Val Glu
                1685                1690                1695    
Leu Val Arg Tyr Glu Pro Asp Leu Leu Arg Leu Leu Gly Ser Glu Val
            1700                1705                1710        
Glu Phe Gln Ser Cys Asn Ser
        1715                


<210> 7342
<211> 684
<212> PRT
<213> Homo sapiens

<400> 7342
Met Ser Ala Ile Pro Ala Glu Glu Ser Asp Gln Leu Leu Ile Arg Pro
 1               5                  10                  15      
Leu Gly Ala Gly Gln Glu Val Gly Arg Ser Cys Ile Ile Leu Glu Phe
            20                  25                  30          
Lys Gly Arg Lys Ile Met Leu Asp Cys Gly Ile His Pro Gly Leu Glu
        35                  40                  45              
Gly Met Asp Ala Leu Pro Tyr Ile Asp Leu Ile Asp Pro Ala Glu Ile
    50                  55                  60                  
Asp Leu Leu Leu Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu
65                  70                  75                  80  
Pro Trp Phe Leu Gln Lys Thr Ser Phe Lys Gly Arg Thr Phe Met Thr
                85                  90                  95      
His Ala Thr Lys Ala Ile Tyr Arg Trp Leu Leu Ser Asp Tyr Val Lys
            100                 105                 110         
Val Ser Asn Ile Ser Ala Asp Asp Met Leu Tyr Thr Glu Thr Asp Leu
        115                 120                 125             
Glu Glu Ser Met Asp Lys Ile Glu Thr Ile Asn Phe His Glu Val Lys
    130                 135                 140                 
Glu Val Ala Gly Ile Lys Phe Trp Cys Tyr His Ala Gly His Val Leu
145                 150                 155                 160 
Gly Ala Ala Met Phe Met Ile Glu Ile Ala Gly Val Lys Leu Leu Tyr
                165                 170                 175     
Thr Gly Asp Phe Ser Arg Gln Glu Asp Arg His Leu Met Ala Ala Glu
            180                 185                 190         
Ile Pro Asn Ile Lys Pro Asp Ile Leu Ile Ile Glu Ser Thr Tyr Gly
        195                 200                 205             
Thr His Ile His Glu Lys Arg Glu Glu Arg Glu Ala Arg Phe Cys Asn
    210                 215                 220                 
Thr Val His Asp Ile Val Asn Arg Gly Gly Arg Gly Leu Ile Pro Val
225                 230                 235                 240 
Phe Ala Leu Gly Arg Ala Gln Glu Leu Leu Leu Ile Leu Asp Glu Tyr
                245                 250                 255     
Trp Gln Asn His Pro Glu Leu His Asp Ile Pro Ile Tyr Tyr Ala Ser
            260                 265                 270         
Ser Leu Ala Lys Lys Cys Met Ala Val Tyr Gln Thr Tyr Val Asn Ala
        275                 280                 285             
Met Asn Asp Lys Ile Arg Lys Gln Ile Asn Ile Asn Asn Pro Phe Val
    290                 295                 300                 
Phe Lys His Ile Ser Asn Leu Lys Ser Met Asp His Phe Asp Asp Ile
305                 310                 315                 320 
Gly Pro Ser Val Val Met Ala Ser Pro Gly Met Met Gln Ser Gly Leu
                325                 330                 335     
Ser Arg Glu Leu Phe Glu Ser Trp Cys Thr Asp Lys Arg Asn Gly Val
            340                 345                 350         
Ile Ile Ala Gly Tyr Cys Val Glu Gly Thr Leu Ala Lys His Ile Met
        355                 360                 365             
Ser Glu Pro Glu Glu Ile Thr Thr Met Ser Gly Gln Lys Leu Pro Leu
    370                 375                 380                 
Lys Met Ser Val Asp Tyr Ile Ser Phe Ser Ala His Thr Asp Tyr Gln
385                 390                 395                 400 
Gln Thr Ser Glu Phe Ile Arg Ala Leu Lys Pro Pro His Val Ile Leu
                405                 410                 415     
Val His Gly Glu Gln Asn Glu Met Ala Arg Leu Lys Ala Ala Leu Ile
            420                 425                 430         
Arg Glu Tyr Glu Asp Asn Asp Glu Val His Ile Glu Val His Asn Pro
        435                 440                 445             
Arg Asn Thr Glu Ala Val Thr Leu Asn Phe Arg Gly Glu Lys Leu Ala
    450                 455                 460                 
Lys Val Met Gly Phe Leu Ala Asp Lys Lys Pro Glu Gln Gly Gln Arg
465                 470                 475                 480 
Val Ser Gly Ile Leu Val Lys Arg Asn Phe Asn Tyr His Ile Leu Ser
                485                 490                 495     
Pro Cys Asp Leu Ser Asn Tyr Thr Asp Leu Ala Met Ser Thr Val Lys
            500                 505                 510         
Gln Thr Gln Ala Ile Pro Tyr Thr Gly Pro Phe Asn Leu Leu Cys Tyr
        515                 520                 525             
Gln Leu Gln Lys Leu Thr Gly Asp Val Glu Glu Leu Glu Ile Gln Glu
    530                 535                 540                 
Lys Pro Ala Leu Lys Val Phe Lys Asn Ile Thr Val Ile Gln Glu Pro
545                 550                 555                 560 
Gly Met Val Val Leu Glu Trp Leu Ala Asn Pro Ser Asn Asp Met Tyr
                565                 570                 575     
Ala Asp Thr Val Thr Thr Val Ile Leu Glu Val Gln Ser Asn Pro Lys
            580                 585                 590         
Ile Arg Lys Gly Ala Val Gln Lys Val Ser Lys Lys Leu Glu Met His
        595                 600                 605             
Val Tyr Ser Lys Arg Leu Glu Ile Met Leu Gln Asp Ile Phe Gly Glu
    610                 615                 620                 
Asp Cys Val Ser Val Lys Asp Asp Ser Ile Leu Ser Val Thr Val Asp
625                 630                 635                 640 
Gly Lys Thr Ala Asn Leu Asn Leu Glu Thr Arg Thr Val Glu Cys Glu
                645                 650                 655     
Glu Gly Ser Glu Asp Asp Glu Ser Leu Arg Glu Met Val Glu Leu Ala
            660                 665                 670         
Ala Gln Arg Leu Tyr Glu Ala Leu Thr Pro Val His
        675                 680                 


<210> 7343
<211> 748
<212> PRT
<213> Homo sapiens

<400> 7343
Thr His Glu Glu His His Ala Ala Lys Thr Leu Gly Ile Gly Lys Ala
 1               5                  10                  15      
Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala Ala
            20                  25                  30          
Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Ala Arg Val Phe
        35                  40                  45              
Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Asp His Ile
    50                  55                  60                  
Lys Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu Gly Gly
65                  70                  75                  80  
Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg Glu Gly
                85                  90                  95      
Arg Leu Arg Ala Ala Tyr Asn Leu Val Lys Arg Gly Ile Thr Asn Leu
            100                 105                 110         
Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr Phe Arg
        115                 120                 125             
Ser Glu Trp Ser Asp Leu Leu Ser Asp Leu Gln Lys Ala Gly Lys Ile
    130                 135                 140                 
Thr Asp Glu Glu Ala Thr Lys Ser Ser Tyr Leu Asn Ile Val Gly Leu
145                 150                 155                 160 
Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile Gly
                165                 170                 175     
Thr Asp Ser Ala Leu His Arg Ile Met Glu Ile Val Asp Ala Ile Thr
            180                 185                 190         
Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met Gly
        195                 200                 205             
Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys Gly Ala
    210                 215                 220                 
Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp Glu Glu
225                 230                 235                 240 
His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser Arg Leu
                245                 250                 255     
Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly Lys Pro
            260                 265                 270         
Ile Thr Ser Glu Asp Ile Lys Asn Gly Ser Arg Met Gly Val Glu Ala
        275                 280                 285             
Val Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys Val Val
    290                 295                 300                 
Ser Leu Ser Gly Asn Gln Ala Val Arg Leu Pro Leu Met Glu Cys Val
305                 310                 315                 320 
Gln Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Lys Phe Asp
                325                 330                 335     
Glu Ala Leu Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp Glu Val
            340                 345                 350         
Tyr Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Ser Gly Ser
        355                 360                 365             
His Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly Met Asn
    370                 375                 380                 
Ala Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly Asn Arg
385                 390                 395                 400 
Val Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Ile
                405                 410                 415     
Glu Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln Gly Gly
            420                 425                 430         
Ser Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Ser Phe Glu Gln
        435                 440                 445             
Ile Ser Ala Asn Ile Thr Lys Phe Asn Ile Gln Gly Leu Val Ile Ile
    450                 455                 460                 
Gly Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu Gly Arg
465                 470                 475                 480 
Lys Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro Ala Thr
                485                 490                 495     
Val Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Val Gly Ala Asp Thr
            500                 505                 510         
Ala Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln Ser Ala
        515                 520                 525             
Ala Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly Gly Tyr
    530                 535                 540                 
Cys Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala Asp Ala
545                 550                 555                 560 
Ala Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln Ala Asn
                565                 570                 575     
Val Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg Gly Leu
            580                 585                 590         
Val Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe Ile
        595                 600                 605             
Phe Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser Arg Lys
    610                 615                 620                 
Asn Val Leu Gly His Met Gln Gln Gly Gly Ser Pro Thr Pro Phe Asp
625                 630                 635                 640 
Arg Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Met Asn Trp Met Ser
                645                 650                 655     
Gly Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala Asn Thr
            660                 665                 670         
Pro Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu Val Phe
        675                 680                 685             
Gln Pro Val Ala Glu Leu Lys Asp Gln Thr Asp Phe Glu His Arg Ile
    690                 695                 700                 
Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys Ile Leu
705                 710                 715                 720 
Ala Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His Leu Glu
                725                 730                 735     
His Ile Thr Arg Lys Arg Ser Gly Glu Ala Ala Val
            740                 745             


<210> 7344
<211> 780
<212> PRT
<213> Homo sapiens

<400> 7344
Met Thr His Glu Glu His His Ala Ala Lys Thr Leu Gly Ile Gly Lys
 1               5                  10                  15      
Ala Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala
            20                  25                  30          
Ala Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Ala Arg Val
        35                  40                  45              
Phe Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Asp His
    50                  55                  60                  
Ile Lys Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu Gly
65                  70                  75                  80  
Gly Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg Glu
                85                  90                  95      
Gly Arg Leu Arg Ala Ala Tyr Asn Leu Val Lys Arg Gly Ile Thr Asn
            100                 105                 110         
Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr Phe
        115                 120                 125             
Arg Ser Glu Trp Ser Asp Leu Leu Ser Asp Leu Gln Lys Ala Gly Lys
    130                 135                 140                 
Ile Thr Asp Glu Glu Ala Thr Lys Ser Ser Tyr Leu Asn Ile Val Gly
145                 150                 155                 160 
Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile
                165                 170                 175     
Gly Thr Asp Ser Ala Leu His Arg Ile Met Glu Ile Val Asp Ala Ile
            180                 185                 190         
Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met
        195                 200                 205             
Gly Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys Gly
    210                 215                 220                 
Ala Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp Glu
225                 230                 235                 240 
Glu His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser Arg
                245                 250                 255     
Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly Lys
            260                 265                 270         
Pro Ile Thr Ser Glu Asp Ile Lys Asn Leu Val Val Lys Arg Leu Gly
        275                 280                 285             
Tyr Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr
    290                 295                 300                 
Pro Ser Ala Phe Asp Arg Ile Leu Gly Ser Arg Met Gly Val Glu Ala
305                 310                 315                 320 
Val Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys Val Val
                325                 330                 335     
Ser Leu Ser Gly Asn Gln Ala Val Arg Leu Pro Leu Met Glu Cys Val
            340                 345                 350         
Gln Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Lys Phe Asp
        355                 360                 365             
Glu Ala Leu Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp Glu Val
    370                 375                 380                 
Tyr Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Ser Gly Ser
385                 390                 395                 400 
His Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly Met Asn
                405                 410                 415     
Ala Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly Asn Arg
            420                 425                 430         
Val Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Ile
        435                 440                 445             
Glu Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln Gly Gly
    450                 455                 460                 
Ser Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Ser Phe Glu Gln
465                 470                 475                 480 
Ile Ser Ala Asn Ile Thr Lys Phe Asn Ile Gln Gly Leu Val Ile Ile
                485                 490                 495     
Gly Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu Gly Arg
            500                 505                 510         
Lys Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro Ala Thr
        515                 520                 525             
Val Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Val Gly Ala Asp Thr
    530                 535                 540                 
Ala Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln Ser Ala
545                 550                 555                 560 
Ala Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly Gly Tyr
                565                 570                 575     
Cys Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala Asp Ala
            580                 585                 590         
Ala Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln Ala Asn
        595                 600                 605             
Val Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg Gly Leu
    610                 615                 620                 
Val Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe Ile
625                 630                 635                 640 
Phe Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser Arg Lys
                645                 650                 655     
Asn Val Leu Gly His Met Gln Gln Gly Gly Ser Pro Thr Pro Phe Asp
            660                 665                 670         
Arg Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Met Asn Trp Met Ser
        675                 680                 685             
Gly Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala Asn Thr
    690                 695                 700                 
Pro Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu Val Phe
705                 710                 715                 720 
Gln Pro Val Ala Glu Leu Lys Asp Gln Thr Asp Phe Glu His Arg Ile
                725                 730                 735     
Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys Ile Leu
            740                 745                 750         
Ala Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His Leu Glu
        755                 760                 765             
His Ile Thr Arg Lys Arg Ser Gly Glu Ala Ala Val
    770                 775                 780 


<210> 7345
<211> 2285
<212> PRT
<213> Homo sapiens

<400> 7345
Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro
 1               5                  10                  15      
Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg
            20                  25                  30          
Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly
        35                  40                  45              
Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly
    50                  55                  60                  
Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn
65                  70                  75                  80  
Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala
                85                  90                  95      
Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala
            100                 105                 110         
Leu Asn Asn Asn Leu Thr Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser
        115                 120                 125             
Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro
    130                 135                 140                 
Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala
145                 150                 155                 160 
Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln
                165                 170                 175     
Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu
            180                 185                 190         
Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro
        195                 200                 205             
Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro
    210                 215                 220                 
Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro Gly
225                 230                 235                 240 
Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser
                245                 250                 255     
Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly
            260                 265                 270         
Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro Gln
        275                 280                 285             
Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Ser
    290                 295                 300                 
Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro
305                 310                 315                 320 
Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys
                325                 330                 335     
Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly
            340                 345                 350         
Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly
        355                 360                 365             
Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Pro Ser Ser Pro Met
    370                 375                 380                 
Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr Asn Pro
385                 390                 395                 400 
Tyr Ser Gln Gln Gln Gly Pro Pro Ser Asp Pro Gln Gln Gly His Gly
                405                 410                 415     
Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr Pro Met
            420                 425                 430         
Thr Val Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Thr
        435                 440                 445             
Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln
    450                 455                 460                 
Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln
465                 470                 475                 480 
Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Thr Pro His Ala
                485                 490                 495     
Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln
            500                 505                 510         
Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln
        515                 520                 525             
Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln His
    530                 535                 540                 
Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr
545                 550                 555                 560 
Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Thr Leu Ser Gln Gln
                565                 570                 575     
Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Thr Ala Tyr
            580                 585                 590         
Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe
        595                 600                 605             
Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly Gly
    610                 615                 620                 
Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro
625                 630                 635                 640 
Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala
                645                 650                 655     
Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu
            660                 665                 670         
Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His
        675                 680                 685             
Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala
    690                 695                 700                 
Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro
705                 710                 715                 720 
Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Ser Ser Asp Ser Ile
                725                 730                 735     
Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr
            740                 745                 750         
Met Gln Arg Asn Ser Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly
        755                 760                 765             
Ser Ala Leu Ser Pro Arg Gln Leu Ser Gly Gly Gln Ile His Thr Gly
    770                 775                 780                 
Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly
785                 790                 795                 800 
Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn
                805                 810                 815     
Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile
            820                 825                 830         
Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro
        835                 840                 845             
Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly
    850                 855                 860                 
Asn Arg Pro Tyr Gly Pro Asn Asn Gly Gln Tyr Ala Thr Ser Gly Trp
865                 870                 875                 880 
Val Arg Asp Val Ser Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu
                885                 890                 895     
Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro
            900                 905                 910         
Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro
        915                 920                 925             
Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln
    930                 935                 940                 
Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly
945                 950                 955                 960 
Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr
                965                 970                 975     
Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu
            980                 985                 990         
Ser Lys Ser Lys Lys Ser Ser Ser Ser Thr Thr Thr Asn Glu Lys Ile
        995                 1000                1005            
Thr Lys Leu Tyr Glu Leu Gly Gly Gly Pro Glu Arg Lys Met Trp Val
    1010                1015                1020                
Asp Arg Tyr Leu Ala Phe Thr Glu Glu Lys Ala Met Gly Met Thr Asn
1025                1030                1035                1040
Leu Pro Ala Val Gly Arg Lys Pro Leu Asp Leu Tyr Arg Leu Tyr Val
                1045                1050                1055    
Ser Val Lys Glu Ile Gly Gly Leu Thr Gln Val Asn Lys Asn Lys Lys
            1060                1065                1070        
Trp Arg Glu Leu Ala Thr Asn Leu Asn Val Gly Thr Ser Ser Ser Ala
        1075                1080                1085            
Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Cys Leu Tyr Ala Phe Glu
    1090                1095                1100                
Cys Lys Ile Glu Arg Gly Glu Asp Pro Pro Pro Asp Ile Phe Ala Ala
1105                1110                1115                1120
Ala Asp Ser Lys Lys Ser Gln Pro Lys Ile Gln Pro Pro Ser Pro Ala
                1125                1130                1135    
Gly Ser Gly Ser Met Gln Gly Pro Gln Thr Pro Gln Ser Thr Ser Ser
            1140                1145                1150        
Ser Met Ala Glu Gly Gly Asp Leu Lys Pro Pro Thr Pro Ala Ser Thr
        1155                1160                1165            
Pro His Ser Gln Ile Pro Pro Leu Pro Gly Met Ser Arg Ser Asn Ser
    1170                1175                1180                
Val Gly Ile Gln Asp Ala Phe Asn Asp Gly Ser Asp Ser Thr Phe Gln
1185                1190                1195                1200
Lys Arg Asn Ser Met Thr Pro Asn Pro Gly Tyr Gln Pro Ser Met Asn
                1205                1210                1215    
Thr Ser Asp Met Met Gly Arg Met Ser Tyr Glu Pro Asn Lys Asp Pro
            1220                1225                1230        
Tyr Gly Ser Met Arg Lys Ala Pro Gly Ser Asp Pro Phe Met Ser Ser
        1235                1240                1245            
Gly Gln Gly Pro Asn Gly Gly Met Gly Asp Pro Tyr Ser Arg Ala Ala
    1250                1255                1260                
Gly Pro Gly Leu Gly Asn Val Ala Met Gly Pro Arg Gln His Tyr Pro
1265                1270                1275                1280
Tyr Gly Gly Pro Tyr Asp Arg Val Arg Thr Glu Pro Gly Ile Gly Pro
                1285                1290                1295    
Glu Gly Asn Met Ser Thr Gly Ala Pro Gln Ser Asn Leu Met Pro Ser
            1300                1305                1310        
Asn Pro Asp Ser Gly Met Tyr Ser Pro Ser Arg Tyr Pro Pro Gln Gln
        1315                1320                1325            
Gln Gln Gln Gln Gln Gln Arg His Asp Ser Tyr Gly Asn Gln Phe Ser
    1330                1335                1340                
Thr Gln Gly Thr Pro Ser Gly Ser Pro Phe Pro Ser Gln Gln Thr Thr
1345                1350                1355                1360
Met Tyr Gln Gln Gln Gln Gln Asn Tyr Lys Arg Pro Met Asp Gly Thr
                1365                1370                1375    
Tyr Gly Pro Pro Ala Lys Arg His Glu Gly Glu Met Tyr Ser Val Pro
            1380                1385                1390        
Tyr Ser Thr Gly Gln Gly Leu Pro Gln Gln Gln Gln Leu Pro Pro Ala
        1395                1400                1405            
Gln Pro Gln Pro Ala Ser Gln Pro Gln Ala Ala Gln Pro Ser Pro Gln
    1410                1415                1420                
Gln Asp Val Tyr Asn Gln Tyr Gly Asn Ala Tyr Pro Ala Thr Ala Thr
1425                1430                1435                1440
Ala Ala Thr Glu Arg Arg Pro Ala Gly Gly Pro Gln Asn Gln Phe Pro
                1445                1450                1455    
Phe Gln Phe Gly Arg Asp Arg Val Ser Ala Pro Pro Gly Thr Asn Ala
            1460                1465                1470        
Gln Gln Asn Met Pro Pro Gln Met Met Gly Gly Pro Ile Gln Ala Ser
        1475                1480                1485            
Ala Glu Val Ala Gln Gln Gly Thr Met Trp Gln Gly Arg Asn Asp Met
    1490                1495                1500                
Thr Tyr Asn Tyr Ala Asn Arg Gln Ser Thr Gly Ser Ala Pro Gln Gly
1505                1510                1515                1520
Pro Ala Tyr His Gly Val Asn Arg Thr Asp Glu Val Leu His Thr Asp
                1525                1530                1535    
Gln Arg Ala Asn His Glu Gly Ser Trp Pro Ser His Gly Thr Arg Gln
            1540                1545                1550        
Pro Pro Tyr Gly Pro Ser Ala Pro Val Pro Pro Met Thr Arg Pro Pro
        1555                1560                1565            
Pro Ser Asn Tyr Gln Pro Pro Pro Ser Met Gln Asn His Ile Pro Gln
    1570                1575                1580                
Val Ser Ser Pro Ala Pro Leu Pro Arg Pro Met Glu Asn Arg Thr Ser
1585                1590                1595                1600
Pro Ser Lys Ser Pro Phe Leu His Ser Gly Met Lys Met Gln Lys Ala
                1605                1610                1615    
Gly Pro Pro Val Pro Ala Ser His Ile Ala Pro Ala Pro Val Gln Pro
            1620                1625                1630        
Pro Met Ile Arg Arg Asp Ile Thr Phe Pro Pro Gly Ser Val Glu Ala
        1635                1640                1645            
Thr Gln Pro Val Leu Lys Gln Arg Arg Arg Leu Thr Met Lys Asp Ile
    1650                1655                1660                
Gly Thr Pro Glu Ala Trp Arg Val Met Met Ser Leu Lys Ser Gly Leu
1665                1670                1675                1680
Leu Ala Glu Ser Thr Trp Ala Leu Asp Thr Ile Asn Ile Leu Leu Tyr
                1685                1690                1695    
Asp Asp Asn Ser Ile Met Thr Phe Asn Leu Ser Gln Leu Pro Gly Leu
            1700                1705                1710        
Leu Glu Leu Leu Val Glu Tyr Phe Arg Arg Cys Leu Ile Glu Ile Phe
        1715                1720                1725            
Gly Ile Leu Lys Glu Tyr Glu Val Gly Asp Pro Gly Gln Arg Thr Leu
    1730                1735                1740                
Leu Asp Pro Gly Arg Phe Ser Lys Val Ser Ser Pro Ala Pro Met Glu
1745                1750                1755                1760
Gly Gly Glu Glu Glu Glu Glu Leu Leu Gly Pro Lys Leu Glu Glu Glu
                1765                1770                1775    
Glu Glu Glu Glu Val Val Glu Asn Asp Glu Glu Ile Ala Phe Ser Gly
            1780                1785                1790        
Lys Asp Lys Pro Ala Ser Glu Asn Ser Glu Glu Lys Leu Ile Ser Lys
        1795                1800                1805            
Phe Asp Lys Leu Pro Val Lys Ile Val Gln Lys Asn Asp Pro Phe Val
    1810                1815                1820                
Val Asp Cys Ser Asp Lys Leu Gly Arg Val Gln Glu Phe Asp Ser Gly
1825                1830                1835                1840
Leu Leu His Trp Arg Ile Gly Gly Gly Asp Thr Thr Glu His Ile Gln
                1845                1850                1855    
Thr His Phe Glu Ser Lys Thr Glu Leu Leu Pro Ser Arg Pro His Ala
            1860                1865                1870        
Pro Cys Pro Pro Ala Pro Arg Lys His Val Thr Thr Ala Glu Gly Thr
        1875                1880                1885            
Pro Gly Thr Thr Asp Gln Glu Gly Pro Pro Pro Asp Gly Pro Pro Glu
    1890                1895                1900                
Lys Arg Ile Thr Ala Thr Met Asp Asp Met Leu Ser Thr Arg Ser Ser
1905                1910                1915                1920
Thr Leu Thr Glu Asp Gly Ala Lys Ser Ser Glu Ala Ile Lys Glu Ser
                1925                1930                1935    
Ser Lys Phe Pro Phe Gly Ile Ser Pro Ala Gln Ser His Arg Asn Ile
            1940                1945                1950        
Lys Ile Leu Glu Asp Glu Pro His Ser Lys Asp Glu Thr Pro Leu Cys
        1955                1960                1965            
Thr Leu Leu Asp Trp Gln Asp Ser Leu Ala Lys Arg Cys Val Cys Val
    1970                1975                1980                
Ser Asn Thr Ile Arg Ser Leu Ser Phe Val Pro Gly Asn Asp Phe Glu
1985                1990                1995                2000
Met Ser Lys His Pro Gly Leu Leu Leu Ile Leu Gly Lys Leu Ile Leu
                2005                2010                2015    
Leu His His Lys His Pro Glu Arg Lys Gln Ala Pro Leu Thr Tyr Glu
            2020                2025                2030        
Lys Glu Glu Glu Gln Asp Gln Gly Val Ser Cys Asn Lys Val Glu Trp
        2035                2040                2045            
Trp Trp Asp Cys Leu Glu Met Leu Arg Glu Asn Thr Leu Val Thr Leu
    2050                2055                2060                
Ala Asn Ile Ser Gly Gln Leu Asp Leu Ser Pro Tyr Pro Glu Ser Ile
2065                2070                2075                2080
Cys Leu Pro Val Leu Asp Gly Leu Leu His Trp Ala Val Cys Pro Ser
                2085                2090                2095    
Ala Glu Ala Gln Asp Pro Phe Ser Thr Leu Gly Pro Asn Ala Val Leu
            2100                2105                2110        
Ser Pro Gln Arg Leu Val Leu Glu Thr Leu Ser Lys Leu Ser Ile Gln
        2115                2120                2125            
Asp Asn Asn Val Asp Leu Ile Leu Ala Thr Pro Pro Phe Ser Arg Leu
    2130                2135                2140                
Glu Lys Leu Tyr Ser Thr Met Val Arg Phe Leu Ser Asp Arg Lys Asn
2145                2150                2155                2160
Pro Val Cys Arg Glu Met Ala Val Val Leu Leu Ala Asn Leu Ala Gln
                2165                2170                2175    
Gly Asp Ser Leu Ala Ala Arg Ala Ile Ala Val Gln Lys Gly Ser Ile
            2180                2185                2190        
Gly Asn Leu Leu Gly Phe Leu Glu Asp Ser Leu Ala Ala Thr Gln Phe
        2195                2200                2205            
Gln Gln Ser Gln Ala Ser Leu Leu His Met Gln Asn Pro Pro Phe Glu
    2210                2215                2220                
Pro Thr Ser Val Asp Met Met Arg Arg Ala Ala Arg Ala Leu Leu Ala
2225                2230                2235                2240
Leu Ala Lys Val Asp Glu Asn His Ser Glu Phe Thr Leu Tyr Glu Ser
                2245                2250                2255    
Arg Leu Leu Asp Ile Ser Val Ser Pro Leu Met Asn Ser Leu Val Ser
            2260                2265                2270        
Gln Val Ile Cys Asp Val Leu Phe Leu Ile Gly Gln Ser
        2275                2280                2285


<210> 7346
<211> 505
<212> PRT
<213> Homo sapiens

<400> 7346
Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile
 1               5                  10                  15      
Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr
            20                  25                  30          
Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro
        35                  40                  45              
Glu Val Glu Pro Asp Leu Gly Glu Lys Val His Thr Glu Gly Arg Ser
    50                  55                  60                  
Glu Pro Ile Leu Leu Pro Ser Arg Leu Pro Glu Pro Ala Gly Ala Pro
65                  70                  75                  80  
Gln Pro Gly Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser
                85                  90                  95      
Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln
            100                 105                 110         
Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr
        115                 120                 125             
Glu Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser
    130                 135                 140                 
Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu
145                 150                 155                 160 
His Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser
                165                 170                 175     
Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg
            180                 185                 190         
Arg Arg Ala Ala Ser Met Asp Ser Ser Ser Lys Leu Leu Arg Gly Arg
        195                 200                 205             
Ser Lys Ala Pro Lys Lys Lys Pro Ser Val Leu Pro Ala Pro Pro Glu
    210                 215                 220                 
Gly Ala Thr Pro Thr Ser Pro Val Gly His Phe Ala Lys Trp Ser Gly
225                 230                 235                 240 
Ser Pro Cys Ser Arg Asn Arg Glu Glu Ala Asp Met Trp Thr Thr Phe
                245                 250                 255     
Arg Pro Arg Ser Ser Ser Asn Ala Ser Ser Val Ser Thr Arg Leu Ser
            260                 265                 270         
Pro Leu Arg Pro Glu Ser Glu Val Leu Ala Glu Glu Ile Pro Ala Ser
        275                 280                 285             
Val Ser Ser Tyr Ala Gly Gly Val Pro Pro Thr Leu Asn Glu Gly Leu
    290                 295                 300                 
Glu Leu Leu Asp Gly Leu Asn Leu Thr Ser Ser His Ser Leu Leu Ser
305                 310                 315                 320 
Arg Ser Gly Leu Ser Gly Phe Ser Leu Gln His Pro Gly Val Thr Gly
                325                 330                 335     
Pro Leu His Thr Tyr Ser Ser Ser Leu Phe Ser Pro Ala Glu Gly Pro
            340                 345                 350         
Leu Ser Ala Gly Glu Gly Cys Phe Ser Ser Ser Gln Ala Leu Glu Ala
        355                 360                 365             
Leu Leu Thr Ser Asp Thr Pro Pro Pro Pro Ala Asp Val Leu Met Thr
    370                 375                 380                 
Gln Val Asp Pro Ile Leu Ser Gln Ala Pro Thr Leu Leu Leu Leu Gly
385                 390                 395                 400 
Gly Leu Pro Ser Ser Ser Lys Leu Ala Thr Gly Val Gly Leu Cys Pro
                405                 410                 415     
Lys Pro Leu Glu Ala Arg Gly Pro Ser Ser Leu Val Pro Thr Leu Ser
            420                 425                 430         
Met Ile Ala Pro Pro Pro Val Met Ala Ser Ala Pro Ile Pro Lys Ala
        435                 440                 445             
Leu Gly Thr Pro Val Leu Thr Pro Pro Thr Glu Ala Ala Ser Gln Asp
    450                 455                 460                 
Arg Met Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu
465                 470                 475                 480 
Cys Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly
                485                 490                 495     
Leu Asp Phe Asn Phe Glu Pro Asp Pro
            500                 505 


<210> 7347
<211> 401
<212> PRT
<213> Homo sapiens

<400> 7347
Met Lys Arg Arg Gln Leu Gln Asn Ser Val Gln Gln Thr Glu Lys Gly
 1               5                  10                  15      
Leu Phe Gly Ser Ser Arg Val Gln Tyr Val Val Asp His Ala Met Lys
            20                  25                  30          
Ile Val Phe Leu Asn Thr Asp Pro Ser Ile Val Thr Thr Tyr Asp Ala
        35                  40                  45              
Val Gln Asn Val His Ser Val Trp Thr Leu Arg Arg Val Lys Ser Glu
    50                  55                  60                  
Glu Glu Asn Val Val Leu Lys Phe Ser Glu Gln Gly Gly Thr Pro Gln
65                  70                  75                  80  
Asn Val Ala Thr Ser Ser Ser Leu Thr Ala His Leu Arg Ser Leu Ser
                85                  90                  95      
Lys Gly Asp Ser Pro Val Ile Ser Pro Phe Arg Asn Tyr Ser Ser Ile
            100                 105                 110         
His Ser Gln Ser Arg Ser Thr Ser Ser Pro Ser Leu His Ser Arg Ser
        115                 120                 125             
Pro Ser Ile Ser Asn Met Ala Ala Leu Ser Arg Ala His Ser Pro Ala
    130                 135                 140                 
Leu Gly Val His Ser Phe Ser Gly Val Gln Arg Phe Asn Ile Ser Ser
145                 150                 155                 160 
His Asn Gln Ser Pro Lys Arg His Ser Ile Ser His Ser Pro Asn Ser
                165                 170                 175     
Asn Ser Asn Asp Ser Phe Leu Ala Pro Glu Thr Glu Pro Ile Val Pro
            180                 185                 190         
Glu Leu Cys Ile Asp His Leu Trp Thr Glu Met Ile Thr Asn Ile Ser
        195                 200                 205             
Cys Val Lys Phe Gln Glu Ser Asn Asp Lys Thr Gln Leu Ile Phe Asp
    210                 215                 220                 
Ser Val Thr Asn Ile Pro Ala Lys Asp Ala Ala Pro Val Glu Lys Ile
225                 230                 235                 240 
Asp Thr Met Leu Val Leu Glu Gly Ser Gly Asn Leu Val Leu Tyr Thr
                245                 250                 255     
Gly Val Val Arg Ala Thr Glu Cys Gly Gly Ala Ser Thr Glu Leu Cys
            260                 265                 270         
Ser Val Ser Leu Cys Ala Phe Thr Met Leu Met Asp Tyr Glu Val Asn
        275                 280                 285             
Asn Ile Leu Gly Leu Gly His Thr Phe Trp Ala Leu Leu Ala Ser Pro
    290                 295                 300                 
Lys Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys
305                 310                 315                 320 
Ser Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Ala Gln Gly Ala
                325                 330                 335     
Ser Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Arg Glu
            340                 345                 350         
Glu Cys Ala Ala Lys Cys Glu Glu Asp Lys Glu Phe Thr Cys Arg Ala
        355                 360                 365             
Phe Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn
    370                 375                 380                 
Lys Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu
385                 390                 395                 400 
Lys
    


<210> 7348
<211> 2286
<212> PRT
<213> Homo sapiens

<400> 7348
Met Ser Leu Arg Ser Gly Gly Arg Arg Arg Ala Asp Pro Gly Ala Asp
 1               5                  10                  15      
Gly Glu Ala Ser Arg Asp Asp Gly Ala Thr Ser Ser Val Ser Ala Leu
            20                  25                  30          
Lys Arg Leu Glu Arg Ser Gln Trp Thr Asp Lys Met Asp Leu Arg Phe
        35                  40                  45              
Gly Phe Glu Arg Leu Lys Glu Pro Gly Glu Lys Thr Gly Trp Leu Ile
    50                  55                  60                  
Asn Met His Pro Thr Glu Ile Leu Asp Glu Asp Lys Arg Leu Gly Ser
65                  70                  75                  80  
Ala Val Asp Tyr Tyr Phe Ile Gln Asp Asp Gly Ser Arg Phe Lys Val
                85                  90                  95      
Ala Leu Pro Tyr Lys Pro Tyr Phe Tyr Ile Ala Thr Arg Lys Gly Cys
            100                 105                 110         
Glu Arg Glu Val Ser Ser Phe Leu Ser Lys Lys Phe Gln Gly Lys Ile
        115                 120                 125             
Ala Lys Val Glu Thr Val Pro Lys Glu Asp Leu Asp Leu Pro Asn His
    130                 135                 140                 
Leu Val Gly Leu Lys Arg Asn Tyr Ile Arg Leu Ser Phe His Thr Val
145                 150                 155                 160 
Glu Asp Leu Val Lys Val Arg Lys Glu Ile Ser Pro Ala Val Lys Lys
                165                 170                 175     
Asn Arg Glu Gln Asp His Ala Ser Asp Ala Tyr Thr Ala Leu Leu Ser
            180                 185                 190         
Ser Val Leu Gln Arg Gly Gly Val Ile Thr Asp Glu Glu Glu Thr Ser
        195                 200                 205             
Lys Lys Ile Ala Asp Gln Leu Asp Asn Ile Val Asp Met Arg Glu Tyr
    210                 215                 220                 
Asp Val Pro Tyr His Ile Arg Leu Ser Ile Asp Leu Lys Ile His Val
225                 230                 235                 240 
Ala His Trp Tyr Asn Val Arg Tyr Arg Gly Asn Ala Phe Pro Val Glu
                245                 250                 255     
Ile Thr Arg Arg Asp Asp Leu Val Glu Arg Pro Asp Pro Val Val Leu
            260                 265                 270         
Ala Phe Asp Ile Glu Thr Thr Lys Leu Pro Leu Lys Phe Pro Asp Ala
        275                 280                 285             
Glu Thr Asp Gln Ile Met Met Ile Ser Tyr Met Ile Asp Gly Gln Gly
    290                 295                 300                 
Tyr Leu Ile Thr Asn Arg Glu Ile Val Ser Glu Asp Ile Glu Asp Phe
305                 310                 315                 320 
Glu Phe Thr Pro Lys Pro Glu Tyr Glu Gly Pro Phe Cys Val Phe Asn
                325                 330                 335     
Glu Pro Asp Glu Ala His Leu Ile Gln Arg Trp Phe Glu His Val Gln
            340                 345                 350         
Glu Thr Lys Pro Thr Ile Met Val Thr Tyr Asn Gly Asp Phe Phe Asp
        355                 360                 365             
Trp Pro Phe Val Glu Ala Arg Ala Ala Val His Gly Leu Ser Met Gln
    370                 375                 380                 
Gln Glu Ile Gly Phe Gln Lys Asp Ser Gln Gly Glu Tyr Lys Ala Pro
385                 390                 395                 400 
Gln Cys Ile His Met Asp Cys Leu Arg Trp Val Lys Arg Asp Ser Tyr
                405                 410                 415     
Leu Pro Val Gly Ser His Asn Leu Lys Ala Ala Ala Lys Ala Lys Leu
            420                 425                 430         
Gly Tyr Asp Pro Val Glu Leu Asp Pro Glu Asp Met Cys Arg Met Ala
        435                 440                 445             
Thr Glu Gln Pro Gln Thr Leu Ala Thr Tyr Ser Val Ser Asp Ala Val
    450                 455                 460                 
Ala Thr Tyr Tyr Leu Tyr Met Lys Tyr Val His Pro Phe Ile Phe Ala
465                 470                 475                 480 
Leu Cys Thr Ile Ile Pro Met Glu Pro Asp Glu Val Leu Arg Lys Gly
                485                 490                 495     
Ser Gly Thr Leu Cys Glu Ala Leu Leu Met Val Gln Ala Phe His Ala
            500                 505                 510         
Asn Ile Ile Phe Pro Asn Lys Gln Glu Gln Glu Phe Asn Lys Leu Thr
        515                 520                 525             
Asp Asp Gly His Val Leu Asp Ser Glu Thr Tyr Val Gly Gly His Val
    530                 535                 540                 
Glu Ala Leu Glu Ser Gly Val Phe Arg Ser Asp Ile Pro Cys Arg Phe
545                 550                 555                 560 
Arg Met Asn Pro Ala Ala Phe Asp Phe Leu Leu Gln Arg Val Glu Lys
                565                 570                 575     
Thr Leu Arg His Ala Leu Glu Glu Glu Glu Lys Val Pro Val Glu Gln
            580                 585                 590         
Val Thr Asn Phe Glu Glu Val Cys Asp Glu Ile Lys Ser Lys Leu Ala
        595                 600                 605             
Ser Leu Lys Asp Val Pro Ser Arg Ile Glu Cys Pro Leu Ile Tyr His
    610                 615                 620                 
Leu Asp Val Gly Ala Met Tyr Pro Asn Ile Ile Leu Thr Asn Arg Leu
625                 630                 635                 640 
Gln Pro Ser Ala Met Val Asp Glu Ala Thr Cys Ala Ala Cys Asp Phe
                645                 650                 655     
Asn Lys Pro Gly Ala Asn Cys Gln Arg Lys Met Ala Trp Gln Trp Arg
            660                 665                 670         
Gly Glu Phe Met Pro Ala Ser Arg Ser Glu Tyr His Arg Ile Gln His
        675                 680                 685             
Gln Leu Glu Ser Glu Lys Phe Pro Pro Leu Phe Pro Glu Gly Pro Ala
    690                 695                 700                 
Arg Ala Phe His Glu Leu Ser Arg Glu Glu Gln Ala Lys Tyr Glu Lys
705                 710                 715                 720 
Arg Arg Leu Ala Asp Tyr Cys Arg Lys Ala Tyr Lys Lys Ile His Ile
                725                 730                 735     
Thr Lys Val Glu Glu Arg Leu Thr Thr Ile Cys Gln Arg Glu Asn Ser
            740                 745                 750         
Phe Tyr Val Asp Thr Val Arg Ala Phe Arg Asp Arg Arg Tyr Glu Phe
        755                 760                 765             
Lys Gly Leu His Lys Val Trp Lys Lys Lys Leu Ser Ala Ala Val Glu
    770                 775                 780                 
Val Gly Asp Ala Ala Glu Val Lys Arg Cys Lys Asn Met Glu Val Leu
785                 790                 795                 800 
Tyr Asp Ser Leu Gln Leu Ala His Lys Cys Ile Leu Asn Ser Phe Tyr
                805                 810                 815     
Gly Tyr Val Met Arg Lys Gly Ala Arg Trp Tyr Ser Met Glu Met Ala
            820                 825                 830         
Gly Ile Val Cys Phe Thr Gly Ala Asn Ile Ile Thr Gln Ala Arg Glu
        835                 840                 845             
Leu Ile Glu Gln Ile Gly Arg Pro Leu Glu Leu Asp Thr Asp Gly Ile
    850                 855                 860                 
Trp Cys Val Leu Pro Asn Ser Phe Pro Glu Asn Phe Val Phe Lys Thr
865                 870                 875                 880 
Thr Asn Val Lys Lys Pro Lys Val Thr Ile Ser Tyr Pro Gly Ala Met
                885                 890                 895     
Leu Asn Ile Met Val Lys Glu Gly Phe Thr Asn Asp Gln Tyr Gln Glu
            900                 905                 910         
Leu Ala Glu Pro Ser Ser Leu Thr Tyr Val Thr Arg Ser Glu Asn Ser
        915                 920                 925             
Ile Phe Phe Glu Val Asp Gly Pro Tyr Leu Ala Met Ile Leu Pro Ala
    930                 935                 940                 
Ser Lys Glu Glu Gly Lys Lys Leu Lys Lys Arg Tyr Ala Val Phe Asn
945                 950                 955                 960 
Glu Asp Gly Ser Leu Ala Glu Leu Lys Gly Phe Glu Val Lys Arg Arg
                965                 970                 975     
Gly Glu Leu Gln Leu Ile Lys Ile Phe Gln Ser Ser Val Phe Glu Ala
            980                 985                 990         
Phe Leu Lys Gly Ser Thr Leu Glu Glu Val Tyr Gly Ser Val Ala Lys
        995                 1000                1005            
Val Ala Asp Tyr Trp Leu Asp Val Leu Tyr Ser Lys Ala Ala Asn Met
    1010                1015                1020                
Pro Asp Ser Glu Leu Phe Glu Leu Ile Ser Glu Asn Arg Ser Met Ser
1025                1030                1035                1040
Arg Lys Leu Glu Asp Tyr Gly Glu Gln Lys Ser Thr Ser Ile Ser Thr
                1045                1050                1055    
Ala Lys Arg Leu Ala Glu Phe Leu Gly Asp Gln Met Val Lys Asp Ala
            1060                1065                1070        
Gly Leu Ser Cys Arg Tyr Ile Ile Ser Arg Lys Pro Glu Gly Ser Pro
        1075                1080                1085            
Val Thr Glu Arg Ala Ile Pro Leu Ala Ile Phe Gln Ala Glu Pro Thr
    1090                1095                1100                
Val Arg Lys His Phe Leu Arg Lys Trp Leu Lys Ser Ser Ser Leu Gln
1105                1110                1115                1120
Asp Phe Asp Ile Arg Ala Ile Leu Asp Trp Asp Tyr Tyr Ile Glu Arg
                1125                1130                1135    
Leu Gly Ser Ala Ile Gln Lys Ile Ile Thr Ile Pro Ala Ala Leu Gln
            1140                1145                1150        
Gln Val Lys Asn Pro Val Pro Arg Val Lys His Pro Asp Trp Leu His
        1155                1160                1165            
Lys Lys Leu Leu Glu Lys Asn Asp Val Tyr Lys Gln Lys Lys Ile Ser
    1170                1175                1180                
Glu Leu Phe Thr Leu Glu Gly Arg Arg Gln Val Thr Met Ala Glu Ala
1185                1190                1195                1200
Ser Glu Asp Ser Pro Arg Pro Ser Ala Pro Asp Met Glu Asp Phe Gly
                1205                1210                1215    
Leu Val Lys Leu Pro His Pro Ala Ala Pro Val Thr Val Lys Arg Lys
            1220                1225                1230        
Arg Val Leu Trp Glu Ser Gln Glu Glu Ser Gln Asp Leu Thr Pro Thr
        1235                1240                1245            
Val Pro Trp Gln Glu Ile Leu Gly Gln Pro Pro Ala Leu Gly Thr Ser
    1250                1255                1260                
Gln Glu Glu Trp Leu Val Trp Leu Arg Phe His Lys Lys Lys Trp Gln
1265                1270                1275                1280
Leu Gln Ala Arg Gln Arg Leu Ala Arg Arg Lys Arg Gln Arg Leu Glu
                1285                1290                1295    
Ser Ala Glu Gly Val Leu Arg Pro Gly Ala Ile Arg Asp Gly Pro Ala
            1300                1305                1310        
Thr Gly Leu Gly Ser Phe Leu Arg Arg Thr Ala Arg Ser Ile Leu Asp
        1315                1320                1325            
Leu Pro Trp Gln Ile Val Gln Ile Ser Glu Thr Ser Gln Ala Gly Leu
    1330                1335                1340                
Phe Arg Leu Trp Ala Leu Val Gly Ser Asp Leu His Cys Ile Arg Leu
1345                1350                1355                1360
Ser Ile Pro Arg Val Phe Tyr Val Asn Gln Arg Val Ala Lys Ala Glu
                1365                1370                1375    
Glu Gly Ala Ser Tyr Arg Lys Val Asn Arg Val Leu Pro Arg Ser Asn
            1380                1385                1390        
Met Val Tyr Asn Leu Tyr Glu Tyr Ser Val Pro Glu Asp Met Tyr Gln
        1395                1400                1405            
Glu His Ile Asn Glu Ile Asn Ala Glu Leu Ser Ala Pro Asp Ile Glu
    1410                1415                1420                
Gly Val Tyr Glu Thr Gln Val Pro Leu Leu Phe Arg Ala Leu Val His
1425                1430                1435                1440
Leu Gly Cys Val Cys Val Val Asn Lys Gln Leu Val Arg His Leu Ser
                1445                1450                1455    
Gly Trp Glu Ala Glu Thr Phe Ala Leu Glu His Leu Glu Met Arg Ser
            1460                1465                1470        
Leu Ala Gln Phe Ser Tyr Leu Glu Pro Gly Ser Ile Arg His Ile Tyr
        1475                1480                1485            
Leu Tyr His His Ala Gln Ala His Lys Ala Leu Phe Gly Ile Phe Ile
    1490                1495                1500                
Pro Ser Gln Arg Arg Ala Ser Val Phe Val Leu Asp Thr Val Arg Ser
1505                1510                1515                1520
Asn Gln Met Pro Ser Leu Gly Ala Leu Tyr Ser Ala Glu His Gly Leu
                1525                1530                1535    
Leu Leu Glu Lys Val Gly Pro Glu Leu Leu Pro Pro Pro Lys His Thr
            1540                1545                1550        
Phe Glu Val Arg Ala Glu Thr Asp Leu Lys Thr Ile Cys Arg Ala Ile
        1555                1560                1565            
Gln Arg Phe Leu Leu Ala Tyr Lys Glu Glu Arg Arg Gly Pro Thr Leu
    1570                1575                1580                
Ile Ala Val Gln Ser Ser Trp Glu Leu Lys Arg Leu Ala Ser Glu Ile
1585                1590                1595                1600
Pro Val Leu Glu Glu Phe Pro Leu Val Pro Ile Cys Val Ala Asp Lys
                1605                1610                1615    
Ile Asn Tyr Gly Val Leu Asp Trp Gln Arg His Gly Ala Arg Arg Met
            1620                1625                1630        
Ile Arg His Tyr Leu Asn Leu Asp Thr Cys Leu Ser Gln Ala Phe Glu
        1635                1640                1645            
Met Ser Arg Tyr Phe His Ile Pro Ile Gly Asn Leu Pro Glu Asp Ile
    1650                1655                1660                
Ser Thr Phe Gly Ser Asp Leu Phe Phe Ala Arg His Leu Gln Arg His
1665                1670                1675                1680
Asn His Leu Leu Trp Leu Ser Pro Thr Ala Arg Pro Asp Leu Gly Gly
                1685                1690                1695    
Lys Glu Ala Asp Asp Asn Cys Leu Val Met Glu Phe Asp Asp Gln Ala
            1700                1705                1710        
Thr Val Glu Ile Asn Ser Ser Gly Cys Tyr Ser Thr Val Cys Val Glu
        1715                1720                1725            
Leu Asp Leu Gln Asn Leu Ala Val Asn Thr Ile Leu Gln Ser His His
    1730                1735                1740                
Val Asn Asp Met Glu Gly Ala Asp Ser Met Gly Ile Ser Phe Asp Val
1745                1750                1755                1760
Ile Gln Gln Ala Ser Leu Glu Asp Met Ile Thr Gly Gly Gln Ala Ala
                1765                1770                1775    
Ser Ala Pro Ala Ser Tyr Asp Glu Thr Ala Leu Cys Ser Asn Thr Phe
            1780                1785                1790        
Arg Ile Leu Lys Ser Met Val Val Gly Trp Val Lys Glu Ile Thr Gln
        1795                1800                1805            
Tyr His Asn Ile Tyr Ala Asp Asn Gln Val Met His Phe Tyr Arg Trp
    1810                1815                1820                
Leu Arg Ser Pro Ser Ser Leu Leu His Asp Pro Ala Leu His Arg Thr
1825                1830                1835                1840
Leu His Asn Met Met Lys Lys Leu Phe Leu Gln Leu Ile Ala Glu Phe
                1845                1850                1855    
Lys Arg Leu Gly Ser Ser Val Ile Tyr Ala Asn Phe Asn Arg Ile Ile
            1860                1865                1870        
Leu Cys Thr Lys Lys Arg Arg Val Glu Asp Ala Ile Ala Tyr Val Glu
        1875                1880                1885            
Tyr Ile Thr Ser Ser Ile His Ser Lys Glu Thr Phe His Ser Leu Thr
    1890                1895                1900                
Ile Ser Phe Ser Arg Cys Trp Glu Phe Leu Leu Trp Met Asp Pro Ser
1905                1910                1915                1920
Asn Tyr Gly Gly Ile Lys Gly Lys Val Ser Ser Arg Ile His Cys Gly
                1925                1930                1935    
Leu Gln Asp Ser Gln Lys Ala Gly Gly Ala Glu Asp Glu Gln Glu Asn
            1940                1945                1950        
Glu Asp Asp Glu Glu Glu Arg Asp Gly Glu Glu Glu Glu Glu Ala Glu
        1955                1960                1965            
Glu Ser Asn Val Glu Asp Leu Leu Glu Asn Asn Trp Asn Ile Leu Gln
    1970                1975                1980                
Phe Leu Pro Gln Ala Ala Ser Cys Gln Asn Tyr Phe Leu Met Ile Val
1985                1990                1995                2000
Ser Ala Tyr Ile Val Ala Val Tyr His Cys Met Lys Asp Gly Leu Arg
                2005                2010                2015    
Arg Ser Ala Pro Gly Ser Thr Pro Val Arg Arg Arg Gly Ala Ser Gln
            2020                2025                2030        
Leu Ser Gln Glu Ala Glu Gly Ala Val Gly Ala Leu Pro Gly Met Ile
        2035                2040                2045            
Thr Phe Ser Gln Asp Tyr Val Ala Asn Glu Leu Thr Gln Ser Phe Phe
    2050                2055                2060                
Thr Ile Thr Gln Lys Ile Gln Lys Lys Val Thr Gly Ser Arg Asn Ser
2065                2070                2075                2080
Thr Glu Leu Ser Glu Met Phe Pro Val Leu Pro Gly Ser His Leu Leu
                2085                2090                2095    
Leu Asn Asn Pro Ala Leu Glu Phe Ile Lys Tyr Val Cys Lys Val Leu
            2100                2105                2110        
Ser Leu Asp Thr Asn Ile Thr Asn Gln Val Asn Lys Leu Asn Arg Asp
        2115                2120                2125            
Leu Leu Arg Leu Val Asp Val Gly Glu Phe Ser Glu Glu Ala Gln Phe
    2130                2135                2140                
Arg Asp Pro Cys Arg Ser Tyr Val Leu Pro Glu Val Ile Cys Arg Ser
2145                2150                2155                2160
Cys Asn Phe Cys Arg Asp Leu Asp Leu Cys Lys Asp Ser Ser Phe Ser
                2165                2170                2175    
Glu Asp Gly Ala Val Leu Pro Gln Trp Leu Cys Ser Asn Cys Gln Ala
            2180                2185                2190        
Pro Tyr Asp Ser Ser Ala Ile Glu Met Thr Leu Val Glu Val Leu Gln
        2195                2200                2205            
Lys Lys Leu Met Ala Phe Thr Leu Gln Asp Leu Val Cys Leu Lys Cys
    2210                2215                2220                
Arg Gly Val Lys Glu Thr Ser Met Pro Val Tyr Cys Thr Cys Ala Gly
2225                2230                2235                2240
Asp Phe Ala Leu Thr Ile His Thr Gln Val Phe Met Glu Gln Ile Gly
                2245                2250                2255    
Ile Phe Arg Asn Ile Ala Gln His Tyr Gly Met Ser Tyr Leu Leu Glu
            2260                2265                2270        
Thr Leu Glu Trp Leu Leu Gln Lys Asn Pro Gln Leu Gly His
        2275                2280                2285    


<210> 7349
<211> 1917
<212> PRT
<213> Homo sapiens

<400> 7349
Met Gln Leu Arg Ile Arg Gln Glu Ile Glu Lys Glu Lys Lys Thr Glu
 1               5                  10                  15      
Pro Trp Lys Glu Lys Phe Phe Glu Arg Phe Tyr Gly Glu Lys Leu Gly
            20                  25                  30          
Met Ser Arg Glu Glu Ser Val Lys Leu Thr Thr Gly Pro Asn Asn Ala
        35                  40                  45              
Gly Ala Gln Ser Ser Ser Ser Cys Gly Thr Ser Gly Leu Pro Val Ser
    50                  55                  60                  
Ala Gln Thr Ala Leu Ala Glu Gln Gln Pro Lys Ser Met Lys Ser Pro
65                  70                  75                  80  
Ala Ser Pro Glu Pro Gly Phe Cys Ala Thr Leu Cys Pro Met Val Glu
                85                  90                  95      
Ile Pro Pro Lys Asp Ile Met Ala Glu Leu Glu Ser Glu Asp Ile Leu
            100                 105                 110         
Ile Pro Glu Glu Ser Val Ile Gln Glu Glu Ile Ala Glu Glu Val Glu
        115                 120                 125             
Thr Ser Ile Cys Glu Cys Gln Asp Glu Asn His Lys Thr Ile Pro Glu
    130                 135                 140                 
Phe Ser Glu Glu Ala Glu Ser Leu Thr Asn Ser His Glu Glu Pro Gln
145                 150                 155                 160 
Ile Ala Pro Pro Glu Asp Asn Leu Glu Ser Cys Val Met Met Asn Asp
                165                 170                 175     
Val Leu Glu Thr Leu Pro His Ile Glu Val Lys Ile Glu Gly Lys Ser
            180                 185                 190         
Glu Ser Pro Gln Glu Glu Met Thr Val Val Ile Asp Gln Leu Glu Val
        195                 200                 205             
Cys Asp Ser Leu Ile Pro Ser Thr Ser Ser Met Thr His Val Ser Asp
    210                 215                 220                 
Thr Glu His Lys Glu Ser Glu Thr Ala Val Glu Thr Ser Thr Pro Lys
225                 230                 235                 240 
Ile Lys Thr Gly Ser Ser Ser Leu Glu Gly Gln Phe Pro Asn Glu Gly
                245                 250                 255     
Ile Ala Ile Asp Met Glu Leu Gln Ser Asp Pro Glu Glu Gln Leu Ser
            260                 265                 270         
Glu Asn Ala Cys Ile Ser Glu Thr Ser Phe Ser Ser Glu Ser Pro Glu
        275                 280                 285             
Gly Ala Cys Thr Ser Leu Pro Ser Pro Gly Gly Glu Thr Gln Ser Thr
    290                 295                 300                 
Ser Glu Glu Ser Cys Thr Pro Ala Ser Leu Glu Thr Thr Phe Cys Ser
305                 310                 315                 320 
Glu Val Ser Ser Thr Glu Asn Thr Asp Lys Tyr Asn Gln Arg Asn Ser
                325                 330                 335     
Thr Asp Glu Asn Phe His Ala Ser Leu Met Ser Glu Ile Ser Pro Ile
            340                 345                 350         
Ser Thr Ser Pro Glu Ile Ser Glu Ala Ser Leu Met Ser Asn Leu Pro
        355                 360                 365             
Leu Thr Ser Glu Ala Ser Pro Val Ser Asn Leu Pro Leu Thr Ser Glu
    370                 375                 380                 
Thr Ser Pro Met Ser Asp Leu Pro Leu Thr Ser Glu Thr Ser Ser Val
385                 390                 395                 400 
Ser Ser Met Leu Leu Thr Ser Glu Thr Thr Phe Val Ser Ser Leu Pro
                405                 410                 415     
Leu Pro Ser Glu Thr Ser Pro Ile Ser Asn Ser Ser Ile Asn Glu Arg
            420                 425                 430         
Met Ala His Gln Gln Arg Lys Ser Pro Ser Val Ser Glu Glu Pro Leu
        435                 440                 445             
Ser Pro Gln Lys Asp Glu Ser Ser Ala Thr Ala Lys Pro Leu Gly Glu
    450                 455                 460                 
Asn Leu Thr Ser Gln Gln Lys Asn Leu Ser Asn Thr Pro Glu Pro Ile
465                 470                 475                 480 
Ile Met Ser Ser Ser Ser Ile Ala Pro Glu Ala Phe Pro Ser Glu Asp
                485                 490                 495     
Leu His Asn Lys Thr Leu Ser Gln Gln Thr Cys Lys Ser His Val Asp
            500                 505                 510         
Thr Glu Lys Pro Tyr Pro Ala Ser Ile Pro Glu Leu Ala Ser Thr Glu
        515                 520                 525             
Met Ile Lys Val Lys Asn His Ser Val Leu Gln Arg Thr Glu Lys Lys
    530                 535                 540                 
Val Leu Pro Ser Pro Leu Glu Leu Ser Val Phe Ser Glu Gly Thr Asp
545                 550                 555                 560 
Asn Lys Gly Asn Glu Leu Pro Ser Ala Lys Leu Gln Asp Lys Gln Tyr
                565                 570                 575     
Ile Ser Ser Val Asp Lys Ala Pro Phe Ser Glu Gly Ser Arg Asn Lys
            580                 585                 590         
Thr His Lys Gln Gly Ser Thr Gln Ser Arg Leu Glu Thr Ser His Thr
        595                 600                 605             
Ser Lys Ser Ser Glu Pro Ser Lys Ser Pro Asp Gly Ile Arg Asn Glu
    610                 615                 620                 
Ser Arg Asp Ser Glu Ile Ser Lys Arg Lys Thr Ala Glu Gln His Ser
625                 630                 635                 640 
Phe Gly Ile Cys Lys Glu Lys Arg Ala Arg Ile Glu Asp Asp Gln Ser
                645                 650                 655     
Thr Arg Asn Ile Ser Ser Ser Ser Pro Pro Glu Lys Glu Gln Pro Pro
            660                 665                 670         
Arg Glu Glu Pro Arg Val Pro Pro Leu Lys Ile Gln Leu Ser Lys Ile
        675                 680                 685             
Gly Pro Pro Phe Ile Ile Lys Ser Gln Pro Val Ser Lys Pro Glu Ser
    690                 695                 700                 
Arg Ala Ser Thr Ser Thr Ser Val Ser Gly Gly Arg Asn Thr Gly Ala
705                 710                 715                 720 
Arg Thr Leu Ala Asp Ile Lys Ala Arg Ala Gln Gln Ala Arg Ala Gln
                725                 730                 735     
Arg Glu Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ser Ile Val
            740                 745                 750         
Ser Gly Ala Met Gly Ser Pro Gly Glu Gly Gly Lys Thr Arg Thr Leu
        755                 760                 765             
Ala His Ile Lys Glu Gln Thr Lys Ala Lys Leu Phe Ala Lys His Gln
    770                 775                 780                 
Ala Arg Ala His Leu Phe Gln Thr Ser Lys Glu Thr Arg Leu Pro Pro
785                 790                 795                 800 
Pro Leu Ser Ser Lys Glu Gly Pro Pro Asn Leu Glu Val Ser Ser Thr
                805                 810                 815     
Pro Glu Thr Lys Met Glu Gly Ser Thr Gly Val Ile Ile Val Asn Pro
            820                 825                 830         
Asn Cys Arg Ser Pro Ser Asn Lys Ser Ala His Leu Arg Glu Thr Thr
        835                 840                 845             
Thr Val Leu Gln Gln Ser Leu Asn Pro Ser Lys Leu Pro Glu Thr Ala
    850                 855                 860                 
Thr Asp Leu Ser Val His Ser Ser Asp Glu Asn Ile Pro Val Ser His
865                 870                 875                 880 
Leu Ser Glu Lys Ile Val Ser Ser Thr Ser Ser Glu Asn Ser Ser Val
                885                 890                 895     
Pro Met Leu Phe Asn Lys Asn Ser Val Pro Val Ser Val Cys Ser Thr
            900                 905                 910         
Ala Ile Ser Gly Ala Ile Lys Glu His Pro Phe Val Ser Ser Val Asp
        915                 920                 925             
Lys Ser Ser Val Leu Met Ser Val Asp Ser Ala Asn Thr Thr Ile Ser
    930                 935                 940                 
Ala Cys Asn Ile Ser Met Leu Lys Thr Ile Gln Gly Thr Asp Thr Pro
945                 950                 955                 960 
Cys Ile Ala Ile Ile Pro Lys Cys Ile Glu Ser Thr Pro Ile Ser Ala
                965                 970                 975     
Thr Thr Glu Gly Ser Ser Ile Ser Ser Ser Met Asp Asp Lys Gln Leu
            980                 985                 990         
Leu Ile Ser Ser Ser Ser Ala Ser Asn Leu Val Ser Thr Gln Tyr Thr
        995                 1000                1005            
Ser Val Pro Thr Pro Ser Ile Gly Asn Asn Leu Pro Asn Leu Ser Thr
    1010                1015                1020                
Ser Ser Val Leu Ile Pro Pro Met Gly Ile Asn Asn Arg Phe Pro Ser
1025                1030                1035                1040
Glu Lys Ile Ala Ile Pro Gly Ser Glu Glu Gln Ala Thr Val Ser Met
                1045                1050                1055    
Gly Thr Thr Val Arg Ala Ala Leu Ser Cys Ser Asp Ser Val Ala Val
            1060                1065                1070        
Thr Asp Ser Leu Val Ala His Pro Thr Val Ala Met Phe Thr Gly Asn
        1075                1080                1085            
Met Leu Thr Ile Asn Ser Tyr Asp Ser Pro Pro Lys Leu Ser Ala Glu
    1090                1095                1100                
Ser Leu Asp Lys Asn Ser Gly Pro Arg Asn Arg Ala Asp Asn Ser Gly
1105                1110                1115                1120
Lys Pro Gln Gln Pro Pro Gly Gly Phe Ala Pro Ala Ala Ile Asn Arg
                1125                1130                1135    
Ser Ile Pro Cys Lys Val Ile Val Asp His Ser Thr Thr Leu Thr Ser
            1140                1145                1150        
Ser Leu Ser Leu Thr Val Ser Val Glu Ser Ser Glu Ala Ser Leu Asp
        1155                1160                1165            
Leu Gln Gly Arg Pro Val Arg Thr Glu Ala Ser Val Gln Pro Val Ala
    1170                1175                1180                
Cys Pro Gln Val Ser Val Ile Ser Arg Pro Glu Pro Val Ala Asn Glu
1185                1190                1195                1200
Gly Ile Asp His Ser Ser Thr Phe Ile Ala Ala Ser Ala Ala Lys Gln
                1205                1210                1215    
Asp Ser Lys Thr Leu Pro Ala Thr Cys Thr Ser Leu Arg Glu Leu Pro
            1220                1225                1230        
Leu Val Pro Asp Lys Leu Asn Glu Pro Thr Ala Pro Ser His Asn Phe
        1235                1240                1245            
Ala Glu Gln Ala Arg Gly Pro Ala Pro Phe Lys Ser Glu Ala Asp Thr
    1250                1255                1260                
Thr Cys Ser Asn Gln Tyr Asn Pro Ser Asn Arg Ile Cys Trp Asn Asp
1265                1270                1275                1280
Asp Gly Met Arg Ser Thr Gly Gln Pro Leu Val Thr His Ser Gly Ser
                1285                1290                1295    
Ser Lys Gln Lys Glu Tyr Leu Glu Gln Ser Cys Pro Lys Ala Ile Lys
            1300                1305                1310        
Thr Glu His Ala Asn Tyr Leu Asn Val Ser Glu Leu His Pro Arg Asn
        1315                1320                1325            
Leu Val Thr Asn Val Ala Leu Pro Val Lys Ser Glu Leu His Glu Ala
    1330                1335                1340                
Asp Lys Gly Phe Arg Met Asp Thr Glu Asp Phe Pro Gly Pro Glu Leu
1345                1350                1355                1360
Pro Pro Pro Ala Ala Glu Gly Ala Ser Ser Val Gln Gln Thr Gln Asn
                1365                1370                1375    
Met Lys Ala Ser Thr Ser Ser Pro Met Glu Glu Ala Ile Ser Leu Ala
            1380                1385                1390        
Thr Asp Ala Leu Lys Arg Val Pro Gly Ala Gly Ser Ser Gly Cys Arg
        1395                1400                1405            
Leu Ser Ser Val Glu Ala Asn Asn Pro Leu Val Thr Gln Leu Leu Gln
    1410                1415                1420                
Gly Asn Leu Pro Leu Glu Lys Val Leu Pro Gln Pro Arg Leu Gly Ala
1425                1430                1435                1440
Lys Leu Glu Ile Asn Arg Leu Pro Leu Pro Leu Gln Thr Thr Ser Val
                1445                1450                1455    
Gly Lys Thr Ala Pro Glu Arg Asn Val Glu Ile Pro Pro Ser Ser Pro
            1460                1465                1470        
Asn Pro Asp Gly Lys Gly Tyr Leu Ala Gly Thr Leu Ala Pro Leu Gln
        1475                1480                1485            
Met Arg Lys Arg Glu Asn His Pro Lys Lys Arg Val Ala Arg Thr Val
    1490                1495                1500                
Gly Glu His Thr Gln Val Lys Cys Glu Pro Gly Lys Leu Leu Val Glu
1505                1510                1515                1520
Pro Asp Val Lys Gly Val Pro Cys Val Ile Ser Ser Gly Ile Ser Gln
                1525                1530                1535    
Leu Gly His Ser Gln Pro Phe Lys Gln Glu Trp Leu Asn Lys His Ser
            1540                1545                1550        
Met Gln Asn Arg Ile Val His Ser Pro Glu Val Lys Gln Gln Lys Arg
        1555                1560                1565            
Leu Leu Pro Ser Cys Ser Phe Gln Gln Asn Leu Phe His Val Asp Lys
    1570                1575                1580                
Asn Gly Gly Phe His Thr Asp Ala Gly Thr Ser His Arg Gln Gln Phe
1585                1590                1595                1600
Tyr Gln Met Pro Val Ala Ala Arg Gly Pro Ile Pro Thr Ala Ala Leu
                1605                1610                1615    
Leu Gln Ala Ser Ser Lys Thr Pro Val Gly Cys Asn Ala Phe Ala Phe
            1620                1625                1630        
Asn Arg His Leu Glu Gln Lys Gly Leu Gly Glu Val Ser Leu Ser Ser
        1635                1640                1645            
Ala Pro His Gln Leu Arg Leu Ala Asn Met Leu Ser Pro Asn Met Pro
    1650                1655                1660                
Met Lys Glu Gly Asp Glu Val Gly Gly Thr Ala His Thr Met Pro Asn
1665                1670                1675                1680
Lys Ala Leu Val His Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
                1685                1690                1695    
Pro Leu Ala Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro
            1700                1705                1710        
Pro Leu Pro Asn Ala Glu Val Pro Ser Asp Gln Lys Gln Pro Pro Val
        1715                1720                1725            
Thr Met Glu Thr Thr Lys Arg Leu Ser Trp Pro Gln Ser Thr Gly Ile
    1730                1735                1740                
Cys Ser Asn Ile Lys Ser Glu Pro Leu Ser Phe Glu Glu Gly Leu Ser
1745                1750                1755                1760
Ser Ser Cys Glu Leu Gly Met Lys Gln Val Ser Tyr Asp Gln Asn Glu
                1765                1770                1775    
Met Lys Glu Gln Leu Lys Ala Phe Ala Leu Lys Ser Ala Asp Phe Ser
            1780                1785                1790        
Ser Tyr Leu Leu Ser Glu Pro Gln Lys Pro Phe Thr Gln Leu Ala Ala
        1795                1800                1805            
Gln Lys Met Gln Val Gln Gln Gln Gln Gln Leu Cys Gly Asn Tyr Pro
    1810                1815                1820                
Thr Ile His Phe Gly Ser Thr Ser Phe Lys Arg Ala Ala Ser Ala Ile
1825                1830                1835                1840
Glu Lys Ser Ile Gly Ile Leu Gly Ser Gly Ser Asn Pro Ala Thr Gly
                1845                1850                1855    
Leu Ser Gly Gln Asn Ala Gln Met Pro Val Gln Asn Phe Ala Asp Ser
            1860                1865                1870        
Ser Asn Ala Asp Glu Leu Glu Leu Lys Cys Ser Cys Arg Leu Lys Ala
        1875                1880                1885            
Met Ile Val Cys Lys Gly Cys Gly Ala Phe Cys His Asp Asp Cys Ile
    1890                1895                1900                
Gly Pro Ser Lys Leu Cys Val Ala Cys Leu Val Val Arg
1905                1910                1915        


<210> 7350
<211> 541
<212> PRT
<213> Homo sapiens

<400> 7350
Met Arg Leu Lys Met Thr Thr Arg Asn Phe Pro Glu Arg Glu Val Pro
 1               5                  10                  15      
Cys Asp Val Glu Val Glu Arg Phe Thr Arg Glu Val Pro Cys Leu Ser
            20                  25                  30          
Ser Leu Gly Asp Gly Trp Asp Cys Glu Asn Gln Glu Gly His Leu Arg
        35                  40                  45              
Gln Ser Ala Leu Thr Leu Glu Lys Pro Gly Thr Gln Glu Ala Ile Cys
    50                  55                  60                  
Glu Tyr Pro Gly Phe Gly Glu His Leu Ile Ala Ser Ser Asp Leu Pro
65                  70                  75                  80  
Pro Ser Gln Arg Val Leu Ala Thr Asn Gly Phe His Ala Pro Asp Ser
                85                  90                  95      
Asn Val Ser Gly Leu Asp Cys Asp Pro Ala Leu Pro Ser Tyr Pro Lys
            100                 105                 110         
Ser Tyr Ala Asp Lys Arg Thr Gly Asp Asn Asp Ala Cys Gly Lys Gly
        115                 120                 125             
Phe Asn His Ser Met Glu Val Ile His Gly Arg Asn Pro Val Arg Glu
    130                 135                 140                 
Lys Pro Tyr Lys Tyr Pro Glu Ser Val Lys Ser Phe Asn His Phe Thr
145                 150                 155                 160 
Ser Leu Gly His Gln Lys Ile Met Lys Arg Gly Lys Lys Ser Tyr Glu
                165                 170                 175     
Gly Lys Asn Phe Glu Asn Ile Phe Thr Leu Ser Ser Ser Leu Asn Glu
            180                 185                 190         
Asn Gln Arg Asn Leu Pro Gly Glu Lys Gln Tyr Arg Cys Thr Glu Cys
        195                 200                 205             
Gly Lys Cys Phe Lys Arg Asn Ser Ser Leu Val Leu His His Arg Thr
    210                 215                 220                 
His Thr Gly Glu Lys Pro Tyr Thr Cys Asn Glu Cys Gly Lys Ser Phe
225                 230                 235                 240 
Ser Lys Asn Tyr Asn Leu Ile Val His Gln Arg Ile His Thr Gly Glu
                245                 250                 255     
Lys Pro Tyr Glu Cys Ser Lys Cys Gly Lys Ala Phe Ser Asp Gly Ser
            260                 265                 270         
Ala Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
        275                 280                 285             
Cys Leu Glu Cys Gly Lys Thr Phe Asn Arg Asn Ser Ser Leu Ile Leu
    290                 295                 300                 
His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Arg Cys Asn Glu Cys
305                 310                 315                 320 
Gly Lys Pro Phe Thr Asp Ile Ser His Leu Thr Val His Leu Arg Ile
                325                 330                 335     
His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Lys Cys Gly Lys Ala Phe
            340                 345                 350         
Arg Asp Gly Ser Tyr Leu Thr Gln His Glu Arg Thr His Thr Gly Glu
        355                 360                 365             
Lys Pro Phe Glu Cys Ala Glu Cys Gly Lys Ser Phe Asn Arg Asn Ser
    370                 375                 380                 
His Leu Ile Val His Gln Lys Ile His Ser Gly Glu Lys Pro Tyr Glu
385                 390                 395                 400 
Cys Lys Glu Cys Gly Lys Thr Phe Ile Glu Ser Ala Tyr Leu Ile Arg
                405                 410                 415     
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Gly Cys Asn Gln Cys
            420                 425                 430         
Gln Lys Leu Phe Arg Asn Ile Ala Gly Leu Ile Arg His Gln Arg Thr
        435                 440                 445             
His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Ala Phe
    450                 455                 460                 
Arg Asp Ser Ser Cys Leu Thr Lys His Gln Arg Ile His Thr Lys Glu
465                 470                 475                 480 
Thr Pro Tyr Gln Cys Pro Glu Cys Gly Lys Ser Phe Lys Gln Asn Ser
                485                 490                 495     
His Leu Ala Val His Gln Arg Leu His Ser Arg Glu Gly Pro Ser Arg
            500                 505                 510         
Cys Pro Gln Cys Gly Lys Met Phe Gln Lys Ser Ser Ser Leu Val Arg
        515                 520                 525             
His Gln Arg Ala His Leu Gly Glu Gln Pro Met Glu Thr
    530                 535                 540     


<210> 7351
<211> 314
<212> PRT
<213> Homo sapiens

<400> 7351
Met Ile Ala Thr Pro Leu Lys His Ser Arg Ile Tyr Leu Pro Pro Glu
 1               5                  10                  15      
Ala Ser Ser Gln Arg Arg Asn Leu Pro Met Asp Ala Ile Phe Phe Asp
            20                  25                  30          
Ser Ile Pro Ser Gly Thr Leu Thr Pro Val Lys Asp Leu Val Lys Tyr
        35                  40                  45              
Gln Asn Ser Ser Leu Lys Leu Asn Asp His Lys Lys Asn Gln Phe Leu
    50                  55                  60                  
Lys Met Thr Thr Phe Asn Asn Lys Asn Ile Phe Gln Ser Thr Met Leu
65                  70                  75                  80  
Thr Glu Ala Thr Thr Ser Asn Ser Ser Leu Asp Ile Ser Ala Ile Lys
                85                  90                  95      
Pro Asn Lys Asp Gly Leu Lys Asn Lys Ala Asn Tyr Glu Ser Pro Gly
            100                 105                 110         
Lys Ile Phe Leu Arg Met Lys Glu Lys Val Leu Arg Asp Lys Gln Glu
        115                 120                 125             
Gln Pro Ser Arg Asn Ser Ser Leu Leu Glu Pro Gln Lys Ser Gly Asn
    130                 135                 140                 
Asn Glu Thr Phe Thr Pro Asn Arg Val Glu Lys Lys Lys Leu Gln His
145                 150                 155                 160 
Thr Tyr Leu Cys Glu Glu Lys Glu Asn Asn Lys Ser Phe Gln Ser Asp
                165                 170                 175     
Asp Ser Ser Leu Arg Ala Ser Val Gln Gly Val Pro Leu Glu Ser Ser
            180                 185                 190         
Asn Asn Asp Ile Phe Leu Pro Val Lys Gln Lys Ile Gln Cys Gln Gln
        195                 200                 205             
Glu Lys Lys Ala Pro Leu His Asn Leu Thr Tyr Glu Leu Pro Thr Leu
    210                 215                 220                 
Asn Gln Glu Gln Glu Asn Phe Leu Ala Val Glu Ala Arg Asn Lys Thr
225                 230                 235                 240 
Leu Thr Arg Ala Gln Leu Ala Lys Gln Ile Phe His Ser Lys Glu Ser
                245                 250                 255     
Ile Val Ala Thr Thr Lys Ser Lys Lys Asp Thr Phe Val Leu Glu Ser
            260                 265                 270         
Val Asp Ser Ala Asp Glu Gln Phe Gln Asn Thr Asn Ala Glu Thr Leu
        275                 280                 285             
Ser Thr Asn Cys Ile Pro Ile Lys Asn Gly Ser Leu Leu Met Val Ser
    290                 295                 300                 
Asp Ser Glu Arg Thr Thr Glu Gly Thr Ser
305                 310                 


<210> 7352
<211> 179
<212> PRT
<213> Homo sapiens

<400> 7352
Met Ile Ala Thr Pro Leu Lys His Ser Arg Ile Tyr Leu Pro Pro Glu
 1               5                  10                  15      
Ala Ser Ser Gln Arg Arg Asn Leu Pro Met Asp Ala Ile Phe Phe Asp
            20                  25                  30          
Ser Ile Pro Ser Gly Thr Leu Thr Pro Val Lys Asp Leu Val Lys Tyr
        35                  40                  45              
Gln Asn Ser Ser Leu Lys Leu Asn Asp His Lys Lys Asn Gln Phe Leu
    50                  55                  60                  
Lys Met Thr Thr Phe Asn Asn Lys Asn Ile Phe Gln Ser Thr Met Leu
65                  70                  75                  80  
Thr Glu Ala Thr Thr Ser Asn Ser Ser Leu Asp Ile Ser Ala Ile Lys
                85                  90                  95      
Pro Asn Lys Asp Gly Leu Lys Asn Lys Ala Asn Tyr Glu Ser Pro Gly
            100                 105                 110         
Lys Ile Phe Leu Arg Met Lys Glu Lys Val Leu Arg Asp Lys Gln Glu
        115                 120                 125             
Gln Pro Ser Arg Asn Ser Ser Leu Leu Glu Pro Gln Lys Ser Gly Asn
    130                 135                 140                 
Asn Glu Thr Phe Thr Pro Asn Arg Val Glu Lys Lys Asn Cys Ser Ile
145                 150                 155                 160 
Pro Thr Tyr Val Lys Lys Arg Lys Thr Thr Asn His Ser Ser Gln Met
                165                 170                 175     
Thr Val His
            


<210> 7353
<211> 721
<212> PRT
<213> Homo sapiens

<400> 7353
Met Ala Gln Gly Leu Glu Val Ala Leu Thr Asp Leu Gln Ser Ser Arg
 1               5                  10                  15      
Asn Asn Val Arg His His Thr Glu Glu Ile Thr Val Asp His Leu Leu
            20                  25                  30          
Val Arg Arg Gly Gln Ala Phe Asn Leu Thr Leu Tyr Phe Arg Asn Arg
        35                  40                  45              
Ser Phe Gln Pro Gly Leu Asp Asn Ile Ile Phe Val Val Glu Thr Gly
    50                  55                  60                  
Pro Leu Pro Asp Leu Ala Leu Gly Thr Arg Ala Val Phe Ser Leu Ala
65                  70                  75                  80  
Arg His His Ser Pro Ser Pro Trp Ile Ala Trp Leu Glu Thr Asn Gly
                85                  90                  95      
Ala Thr Ser Thr Glu Val Ser Leu Cys Ala Pro Pro Thr Ala Ala Val
            100                 105                 110         
Gly Arg Tyr Leu Leu Lys Ile His Ile Asp Ser Phe Gln Gly Ser Val
        115                 120                 125             
Thr Ala Tyr Gln Leu Gly Glu Phe Ile Leu Leu Phe Asn Pro Trp Cys
    130                 135                 140                 
Pro Glu Asp Ala Val Tyr Leu Asp Ser Glu Pro Gln Arg Gln Glu Tyr
145                 150                 155                 160 
Val Met Asn Asp Tyr Gly Phe Ile Tyr Gln Gly Ser Lys Asn Trp Ile
                165                 170                 175     
Arg Pro Cys Pro Trp Asn Tyr Gly Gln Phe Glu Asp Lys Ile Ile Asp
            180                 185                 190         
Ile Cys Leu Lys Leu Leu Asp Lys Ser Leu His Phe Gln Thr Asp Pro
        195                 200                 205             
Ala Thr Asp Cys Ala Leu Arg Gly Ser Pro Val Tyr Val Ser Arg Val
    210                 215                 220                 
Val Cys Ala Met Ile Asn Ser Asn Asp Asp Asn Gly Val Leu Asn Gly
225                 230                 235                 240 
Asn Trp Ser Glu Asn Tyr Thr Asp Gly Ala Asn Pro Ala Glu Trp Thr
                245                 250                 255     
Gly Ser Val Ala Ile Leu Lys Gln Trp Asn Ala Thr Gly Cys Gln Pro
            260                 265                 270         
Val Arg Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Met Cys Thr Val
        275                 280                 285             
Met Arg Cys Leu Gly Ile Pro Thr Arg Val Ile Thr Asn Phe Asp Ser
    290                 295                 300                 
Gly His Asp Thr Asp Gly Asn Leu Ile Ile Asp Glu Tyr Tyr Asp Asn
305                 310                 315                 320 
Thr Gly Arg Ile Leu Gly Asn Lys Lys Lys Asp Thr Ile Trp Asn Phe
                325                 330                 335     
His Val Trp Asn Glu Cys Trp Met Ala Arg Lys Asp Leu Pro Pro Ala
            340                 345                 350         
Tyr Gly Gly Trp Gln Val Leu Asp Ala Thr Pro Gln Glu Met Ser Asn
        355                 360                 365             
Gly Val Tyr Cys Cys Gly Pro Ala Ser Val Arg Ala Ile Lys Glu Gly
    370                 375                 380                 
Glu Val Asp Leu Asn Tyr Asp Thr Pro Phe Val Phe Ser Met Val Asn
385                 390                 395                 400 
Ala Asp Cys Met Ser Trp Leu Val Gln Gly Gly Lys Glu Gln Lys Leu
                405                 410                 415     
His Gln Asp Thr Ser Ser Val Gly Asn Phe Ile Ser Thr Lys Ser Ile
            420                 425                 430         
Gln Ser Asp Glu Arg Asp Asp Ile Thr Glu Asn Tyr Lys Tyr Glu Glu
        435                 440                 445             
Gly Ser Leu Gln Glu Arg Gln Val Phe Leu Lys Ala Leu Gln Lys Leu
    450                 455                 460                 
Lys Ala Arg Ser Phe His Gly Ser Gln Arg Gly Ala Glu Leu Gln Pro
465                 470                 475                 480 
Ser Arg Pro Thr Ser Leu Ser Gln Asp Ser Pro Arg Ser Leu His Thr
                485                 490                 495     
Pro Ser Leu Arg Pro Ser Asp Val Val Gln Val Ser Leu Lys Phe Lys
            500                 505                 510         
Leu Leu Asp Pro Pro Asn Met Gly Gln Asp Ile Cys Phe Val Leu Leu
        515                 520                 525             
Ala Leu Asn Met Ser Ser Gln Phe Lys Asp Leu Lys Val Asn Leu Ser
    530                 535                 540                 
Ala Gln Ser Leu Leu His Asp Gly Ser Pro Leu Ser Pro Phe Trp Gln
545                 550                 555                 560 
Asp Thr Ala Phe Ile Thr Leu Ser Pro Lys Glu Ala Lys Thr Tyr Pro
                565                 570                 575     
Cys Lys Ile Ser Tyr Ser Gln Tyr Ser Gln Tyr Leu Ser Thr Asp Lys
            580                 585                 590         
Leu Ile Arg Ile Ser Ala Leu Gly Glu Glu Lys Ser Ser Pro Glu Lys
        595                 600                 605             
Ile Leu Val Asn Lys Ile Ile Thr Leu Ser Tyr Pro Ser Ile Thr Ile
    610                 615                 620                 
Asn Val Gly Arg Arg Ala Ala Val Val Asn Gln Pro Leu Ser Ile Gln
625                 630                 635                 640 
Val Ile Phe Ser Asn Pro Leu Ser Glu Gln Val Glu Asp Cys Val Leu
                645                 650                 655     
Thr Val Glu Gly Ser Gly Leu Phe Lys Lys Gln Gln Lys Val Phe Leu
            660                 665                 670         
Gly Val Leu Lys Pro Gln His Gln Ala Ser Ile Ile Leu Glu Thr Val
        675                 680                 685             
Pro Phe Lys Ser Gly Gln Arg Gln Ile Gln Ala Asn Met Arg Ser Asn
    690                 695                 700                 
Lys Phe Lys Asp Ile Lys Gly Tyr Arg Asn Val Tyr Val Asp Phe Ala
705                 710                 715                 720 
Leu
    


<210> 7354
<211> 2134
<212> PRT
<213> Homo sapiens

<400> 7354
Met Pro Gly Leu Asp Arg Pro Leu Ser Arg Gln Asn Pro His Asp Gly
 1               5                  10                  15      
Val Val Thr Pro Ala Ala Ser Pro Ser Leu Pro Gln Pro Gly Leu Gln
            20                  25                  30          
Met Pro Gly Gln Trp Gly Pro Val Gln Gly Gly Pro Gln Pro Ser Gly
        35                  40                  45              
Gln His Arg Ser Pro Cys Pro Glu Gly Pro Val Pro Ser Gly Val Pro
    50                  55                  60                  
Cys Ala Thr Ser Val Pro His Phe Pro Thr Pro Ser Ile Leu His Gln
65                  70                  75                  80  
Gly Pro Gly His Glu Gln His Ser Pro Leu Val Ala Pro Pro Ala Ala
                85                  90                  95      
Leu Pro Ser Asp Gly Arg Asp Glu Val Ser His Leu Gln Ser Gly Ser
            100                 105                 110         
His Leu Ala Asn Asn Ser Asp Pro Glu Ser Thr Phe Arg Gln Asn Pro
        115                 120                 125             
Arg Ile Val Asn His Trp Ala Ser Pro Glu Leu Arg Gln Asn Pro Gly
    130                 135                 140                 
Val Lys Asn Glu His Arg Pro Ala Ser Ala Leu Val Asn Pro Leu Ala
145                 150                 155                 160 
Arg Gly Asp Ser Pro Glu Asn Arg Thr His His Pro Leu Gly Ala Gly
                165                 170                 175     
Ala Gly Ser Gly Cys Ala Pro Leu Glu Ala Asp Ser Gly Ala Ser Gly
            180                 185                 190         
Ala Leu Ala Met Phe Phe Gln Gly Gly Glu Thr Glu Asn Glu Glu Asn
        195                 200                 205             
Leu Ser Ser Glu Lys Ala Gly Leu Ser Gly Gln Ala Asp Phe Asp Asp
    210                 215                 220                 
Phe Cys Ser Ser Pro Gly Leu Gly Arg Pro Pro Ala Pro Thr His Val
225                 230                 235                 240 
Gly Ala Gly Ser Leu Cys Gln Ala Leu Leu Pro Gly Pro Ser Asn Glu
                245                 250                 255     
Ala Ala Gly Asp Val Trp Gly Asp Thr Ala Ser Thr Gly Val Pro Asp
            260                 265                 270         
Ala Ser Gly Ser Gln Tyr Glu Asn Val Glu Asn Leu Glu Phe Val Gln
        275                 280                 285             
Asn Gln Glu Val Leu Pro Ser Glu Pro Leu Asn Leu Asp Pro Ser Ser
    290                 295                 300                 
Pro Ser Asp Gln Phe Arg Tyr Gly Pro Leu Pro Gly Pro Ala Val Pro
305                 310                 315                 320 
Arg His Gly Ala Val Cys His Thr Gly Ala Pro Asp Ala Thr Leu His
                325                 330                 335     
Thr Val His Pro Asp Ser Val Ser Ser Ser Tyr Ser Ser Arg Ser His
            340                 345                 350         
Gly Arg Leu Ser Gly Ser Ala Arg Pro Gln Glu Leu Val Gly Thr Phe
        355                 360                 365             
Ile Gln Gln Glu Val Gly Lys Pro Glu Asp Glu Ala Ser Gly Ser Phe
    370                 375                 380                 
Phe Lys Gln Ile Asp Ser Ser Pro Val Gly Gly Glu Thr Asp Glu Thr
385                 390                 395                 400 
Thr Val Ser Gln Asn Tyr Arg Gly Ser Val Ser Gln Pro Ser Thr Pro
                405                 410                 415     
Ser Pro Pro Lys Pro Thr Gly Ile Phe Gln Thr Ser Ala Asn Ser Ser
            420                 425                 430         
Phe Glu Pro Val Lys Ser His Leu Val Gly Val Lys Pro Phe Glu Ala
        435                 440                 445             
Asp Arg Ala Asn Val Val Gly Glu Val Arg Glu Thr Cys Val Arg Gln
    450                 455                 460                 
Lys Gln Cys Arg Pro Ala Ala Ala Leu Pro Asp Ala Ser Pro Gly Asn
465                 470                 475                 480 
Leu Glu Gln Pro Pro Asp Asn Met Glu Thr Leu Cys Ala Pro Gln Val
                485                 490                 495     
Cys Pro Leu Pro Leu Asn Ser Thr Thr Glu Ala Val His Met Leu Pro
            500                 505                 510         
His Ala Gly Ala Pro Pro Leu Asp Thr Val Tyr Pro Ala Pro Glu Lys
        515                 520                 525             
Arg Pro Ser Ala Arg Thr Gln Gly Pro Val Lys Cys Glu Ser Pro Ala
    530                 535                 540                 
Thr Thr Leu Trp Ala Gln Ser Glu Leu Pro Asp Phe Gly Gly Asn Val
545                 550                 555                 560 
Leu Leu Ala Pro Ala Ala Pro Ala Leu Tyr Val Cys Ala Lys Pro Gln
                565                 570                 575     
Pro Pro Val Val Gln Pro Pro Glu Glu Ala Met Ser Gly Gln Gln Ser
            580                 585                 590         
Arg Asn Pro Ser Ser Ala Ala Pro Val Gln Ser Arg Gly Gly Ile Gly
        595                 600                 605             
Ala Ser Glu Asn Leu Glu Asn Pro Pro Lys Met Gly Glu Glu Glu Ala
    610                 615                 620                 
Leu Gln Ser Gln Ala Ser Ser Gly Tyr Ala Ser Leu Leu Ser Ser Pro
625                 630                 635                 640 
Pro Thr Glu Ser Leu Gln Asn Pro Pro Val Leu Ile Ala Gln Pro Asp
                645                 650                 655     
His Ser Tyr Asn Leu Ala Gln Pro Ile Asn Phe Ser Val Ser Leu Ser
            660                 665                 670         
Asn Ser His Glu Lys Asn Gln Ser Trp Arg Glu Ala Leu Val Gly Asp
        675                 680                 685             
Arg Pro Ala Val Ser Ser Trp Ala Leu Gly Gly Asp Ser Gly Glu Asn
    690                 695                 700                 
Thr Ser Leu Ser Gly Ile Pro Thr Ser Ser Val Leu Ser Leu Ser Leu
705                 710                 715                 720 
Pro Ser Ser Val Ala Gln Ser Asn Phe Pro Gln Gly Ser Gly Ala Ser
                725                 730                 735     
Glu Met Val Ser Asn Gln Pro Ala Asn Leu Leu Val Gln Pro Pro Ser
            740                 745                 750         
Gln Pro Val Pro Glu Asn Leu Val Pro Glu Ser Gln Lys Asp Arg Lys
        755                 760                 765             
Ala Gly Ser Ala Leu Pro Gly Phe Ala Asn Ser Pro Ala Gly Ser Thr
    770                 775                 780                 
Ser Val Val Leu Val Pro Pro Ala His Gly Thr Leu Val Pro Asp Gly
785                 790                 795                 800 
Asn Lys Ala Asn His Ser Ser His Gln Glu Asp Thr Tyr Gly Ala Leu
                805                 810                 815     
Asp Phe Thr Leu Ser Arg Thr Leu Glu Asn Pro Val Asn Val Tyr Asn
            820                 825                 830         
Pro Ser His Ser Asp Ser Leu Ala Ser Gln Gln Ser Val Ala Ser His
        835                 840                 845             
Pro Arg Gln Ser Gly Pro Gly Ala Pro Asn Leu Asp Arg Phe Tyr Gln
    850                 855                 860                 
Gln Val Thr Lys Asp Ala Gln Gly Gln Pro Gly Leu Glu Arg Ala Gln
865                 870                 875                 880 
Gln Glu Leu Val Pro Pro Gln Gln Gln Ala Ser Pro Pro Gln Leu Pro
                885                 890                 895     
Lys Ala Met Phe Ser Glu Leu Ser Asn Pro Glu Ser Leu Pro Ala Gln
            900                 905                 910         
Gly Gln Ala Gln Asn Ser Ala Gln Ser Pro Ala Ser Leu Val Leu Val
        915                 920                 925             
Asp Ala Gly Gln Gln Leu Pro Pro Arg Pro Pro Gln Ser Ser Ser Val
    930                 935                 940                 
Ser Leu Val Ser Ser Gly Ser Gly Gln Ala Ala Val Pro Ser Glu Gln
945                 950                 955                 960 
Pro Trp Pro Gln Pro Val Pro Ala Leu Ala Pro Gly Pro Pro Pro Gln
                965                 970                 975     
Asp Leu Ala Ala Tyr Tyr Tyr Tyr Arg Pro Leu Tyr Asp Ala Tyr Gln
            980                 985                 990         
Pro Gln Tyr Ser Leu Pro Tyr Pro Pro Glu Pro Gly Ala Ala Ser Leu
        995                 1000                1005            
Tyr Tyr Gln Asp Val Tyr Ser Leu Tyr Glu Pro Arg Tyr Arg Pro Tyr
    1010                1015                1020                
Asp Gly Ala Ala Ser Ala Tyr Ala Gln Asn Tyr Arg Tyr Pro Glu Pro
1025                1030                1035                1040
Glu Arg Pro Ser Ser Arg Ala Ser His Ser Ser Glu Arg Pro Pro Pro
                1045                1050                1055    
Arg Gln Gly Tyr Pro Glu Gly Tyr Tyr Ser Ser Lys Ser Gly Trp Ser
            1060                1065                1070        
Ser Gln Ser Asp Tyr Tyr Ala Ser Tyr Tyr Ser Ser Gln Tyr Asp Tyr
        1075                1080                1085            
Gly Asp Pro Gly His Trp Asp Arg Tyr His Tyr Ser Ala Arg Val Arg
    1090                1095                1100                
Asp Pro Arg Thr Tyr Asp Arg Arg Tyr Trp Cys Asp Ala Glu Tyr Asp
1105                1110                1115                1120
Ala Tyr Arg Arg Glu His Ser Ala Phe Gly Asp Arg Pro Glu Lys Arg
                1125                1130                1135    
Asp Asn Asn Trp Arg Tyr Asp Pro Arg Phe Thr Gly Ser Phe Asp Asp
            1140                1145                1150        
Asp Pro Asp Pro His Arg Asp Pro Tyr Gly Glu Glu Val Asp Arg Arg
        1155                1160                1165            
Ser Val His Ser Glu His Ser Ala Arg Ser Leu His Ser Ala His Ser
    1170                1175                1180                
Leu Ala Ser Arg Arg Ser Ser Leu Ser Ser His Ser His Gln Ser Gln
1185                1190                1195                1200
Ile Tyr Arg Ser His Asn Val Ala Ala Gly Ser Tyr Glu Ala Pro Leu
                1205                1210                1215    
Pro Pro Gly Ser Phe His Gly Asp Phe Ala Tyr Gly Thr Tyr Arg Ser
            1220                1225                1230        
Asn Phe Ser Ser Gly Pro Gly Phe Pro Glu Tyr Gly Tyr Pro Ala Asp
        1235                1240                1245            
Thr Val Trp Pro Ala Met Glu Gln Val Ser Ser Arg Pro Thr Ser Pro
    1250                1255                1260                
Glu Lys Phe Ser Val Pro His Val Cys Ala Arg Phe Gly Pro Gly Gly
1265                1270                1275                1280
Gln Leu Ile Lys Val Ile Pro Asn Leu Pro Ser Glu Gly Gln Pro Ala
                1285                1290                1295    
Leu Val Glu Val His Ser Met Glu Ala Leu Leu Gln His Thr Ser Glu
            1300                1305                1310        
Gln Glu Glu Met Arg Ala Phe Pro Gly Pro Leu Ala Lys Asp Asp Thr
        1315                1320                1325            
His Lys Val Asp Val Ile Asn Phe Ala Gln Asn Lys Ala Met Lys Cys
    1330                1335                1340                
Leu Gln Asn Glu Asn Leu Ile Asp Lys Glu Ser Ala Ser Leu Leu Trp
1345                1350                1355                1360
Asn Phe Ile Val Leu Leu Cys Arg Gln Asn Gly Thr Val Val Gly Thr
                1365                1370                1375    
Asp Ile Ala Glu Leu Leu Leu Arg Asp His Arg Thr Val Trp Leu Pro
            1380                1385                1390        
Gly Lys Ser Pro Asn Glu Ala Asn Leu Ile Asp Phe Thr Asn Glu Ala
        1395                1400                1405            
Val Glu Gln Val Glu Glu Glu Glu Ser Gly Glu Ala Gln Leu Ser Phe
    1410                1415                1420                
Leu Thr Gly Gly Pro Ala Ala Ala Ala Ser Ser Leu Glu Arg Glu Thr
1425                1430                1435                1440
Glu Arg Phe Arg Glu Leu Leu Leu Tyr Gly Arg Lys Lys Asp Ala Leu
                1445                1450                1455    
Glu Ser Ala Met Lys Asn Gly Leu Trp Gly His Ala Leu Leu Leu Ala
            1460                1465                1470        
Ser Lys Met Asp Ser Arg Thr His Ala Arg Val Met Thr Arg Phe Ala
        1475                1480                1485            
Asn Ser Leu Pro Ile Asn Asp Pro Leu Gln Thr Val Tyr Gln Leu Met
    1490                1495                1500                
Ser Gly Arg Met Pro Ala Ala Ser Thr Cys Cys Gly Asp Glu Lys Trp
1505                1510                1515                1520
Gly Asp Trp Arg Pro His Leu Ala Met Val Leu Ser Asn Leu Asn Asn
                1525                1530                1535    
Asn Met Asp Val Glu Ser Arg Thr Met Ala Thr Met Gly Asp Thr Leu
            1540                1545                1550        
Ala Ser Arg Gly Leu Leu Asp Ala Ala His Phe Cys Tyr Leu Met Ala
        1555                1560                1565            
Gln Ala Gly Phe Gly Val Tyr Thr Lys Lys Thr Thr Lys Leu Val Leu
    1570                1575                1580                
Ile Gly Ser Asn His Ser Leu Pro Phe Leu Lys Phe Ala Thr Asn Glu
1585                1590                1595                1600
Ala Ile Gln Arg Thr Glu Ala Tyr Glu Tyr Ala Gln Ser Leu Gly Ala
                1605                1610                1615    
Glu Thr Cys Pro Leu Pro Ser Phe Gln Val Phe Lys Phe Ile Tyr Ser
            1620                1625                1630        
Cys Arg Leu Ala Glu Met Gly Leu Ala Thr Gln Ala Phe His Tyr Cys
        1635                1640                1645            
Glu Ala Ile Ala Lys Ser Ile Leu Thr Gln Pro His Leu Tyr Ser Pro
    1650                1655                1660                
Val Leu Ile Ser Gln Leu Val Gln Met Ala Ser Gln Leu Arg Leu Phe
1665                1670                1675                1680
Asp Pro Gln Leu Lys Glu Lys Pro Glu Glu Glu Ser Leu Ala Ala Pro
                1685                1690                1695    
Thr Trp Leu Val His Leu Gln Gln Val Glu Arg Gln Ile Lys Glu Gly
            1700                1705                1710        
Ala Gly Val Trp His Gln Asp Gly Ala Leu Pro Gln Gln Cys Pro Gly
        1715                1720                1725            
Thr Pro Ser Ser Glu Met Glu Gln Leu Asp Arg Pro Gly Leu Ser Gln
    1730                1735                1740                
Pro Gly Ala Leu Gly Ile Ala Asn Pro Leu Leu Ala Val Pro Ala Pro
1745                1750                1755                1760
Ser Pro Glu His Ser Ser Pro Ser Val Arg Leu Leu Pro Ser Ala Pro
                1765                1770                1775    
Gln Thr Leu Pro Asp Gly Pro Leu Ala Ser Pro Ala Arg Val Pro Met
            1780                1785                1790        
Phe Pro Val Pro Leu Pro Pro Gly Pro Leu Glu Pro Gly Pro Gly Cys
        1795                1800                1805            
Val Thr Pro Gly Pro Ala Leu Gly Phe Leu Glu Pro Ser Gly Pro Gly
    1810                1815                1820                
Leu Pro Pro Gly Val Pro Pro Leu Gln Glu Arg Arg His Leu Leu Gln
1825                1830                1835                1840
Glu Ala Arg Ser Pro Asp Pro Gly Ile Val Pro Gln Glu Ala Pro Val
                1845                1850                1855    
Gly Asn Ser Leu Ser Glu Leu Ser Glu Glu Asn Phe Asp Gly Lys Phe
            1860                1865                1870        
Ala Asn Leu Thr Pro Ser Arg Thr Val Pro Asp Ser Glu Ala Pro Pro
        1875                1880                1885            
Gly Trp Asp Arg Ala Asp Ser Gly Pro Thr Gln Pro Pro Leu Ser Leu
    1890                1895                1900                
Ser Pro Ala Pro Glu Thr Lys Arg Pro Gly Gln Ala Ala Lys Lys Glu
1905                1910                1915                1920
Thr Lys Glu Pro Lys Lys Gly Glu Ser Trp Phe Phe Arg Trp Leu Pro
                1925                1930                1935    
Gly Lys Lys Lys Thr Glu Ala Tyr Leu Pro Asp Asp Lys Asn Lys Ser
            1940                1945                1950        
Ile Val Trp Asp Glu Lys Lys Asn Gln Trp Val Asn Leu Asn Glu Pro
        1955                1960                1965            
Glu Glu Glu Lys Lys Ala Pro Pro Pro Pro Pro Thr Ser Met Pro Lys
    1970                1975                1980                
Thr Val Gln Ala Ala Pro Pro Ala Leu Pro Gly Pro Pro Gly Ala Pro
1985                1990                1995                2000
Val Asn Met Tyr Ser Arg Arg Ala Ala Gly Thr Arg Ala Arg Tyr Val
                2005                2010                2015    
Asp Val Leu Asn Pro Ser Gly Thr Gln Arg Ser Glu Pro Ala Leu Ala
            2020                2025                2030        
Pro Ala Asp Phe Val Ala Pro Leu Ala Pro Leu Pro Ile Pro Ser Asn
        2035                2040                2045            
Leu Phe Val Pro Thr Pro Asp Ala Glu Glu Pro Gln Leu Pro Asp Gly
    2050                2055                2060                
Thr Gly Arg Glu Gly Pro Ala Ala Ala Arg Gly Leu Ala Asn Pro Glu
2065                2070                2075                2080
Pro Ala Pro Glu Pro Lys Ala Pro Gly Asp Leu Pro Ala Ala Gly Gly
                2085                2090                2095    
Pro Pro Ser Gly Ala Met Pro Phe Tyr Asn Pro Ala Gln Leu Ala Gln
            2100                2105                2110        
Ala Cys Ala Thr Ser Gly Ser Ser Arg Leu Gly Arg Ile Gly Gln Arg
        2115                2120                2125            
Lys His Leu Val Leu Asn
    2130                


<210> 7355
<211> 343
<212> PRT
<213> Homo sapiens

<400> 7355
Val His Asn Asn Ser Lys His Gly Arg Arg Ala Arg Arg Leu Asp Pro
 1               5                  10                  15      
Ser Glu Ala Thr Pro Cys Ile Lys Ala Ile Ser Pro Ser Glu Gly Trp
            20                  25                  30          
Thr Thr Gly Gly Ala Met Val Ile Ile Ile Gly Asp Asn Phe Phe Asp
        35                  40                  45              
Gly Leu Gln Val Val Phe Gly Thr Met Leu Val Trp Ser Glu Leu Ile
    50                  55                  60                  
Thr Pro His Ala Ile Arg Val Gln Thr Pro Pro Arg His Ile Pro Gly
65                  70                  75                  80  
Val Val Glu Val Thr Leu Ser Tyr Lys Ser Lys Gln Phe Cys Lys Gly
                85                  90                  95      
Ala Pro Gly Arg Phe Ile Tyr Thr Ala Leu Asn Glu Pro Thr Ile Asp
            100                 105                 110         
Tyr Gly Phe Gln Arg Leu Gln Lys Val Ile Pro Arg His Pro Gly Asp
        115                 120                 125             
Pro Glu Arg Leu Ala Lys Glu Met Leu Leu Lys Arg Ala Ala Asp Leu
    130                 135                 140                 
Val Glu Ala Leu Tyr Gly Thr Pro His Asn Asn Gln Asp Ile Ile Leu
145                 150                 155                 160 
Lys Arg Ala Ala Asp Ile Ala Glu Ala Leu Tyr Ser Val Pro Arg Asn
                165                 170                 175     
Pro Ser Gln Leu Pro Ala Leu Ser Ser Ser Pro Ala His Ser Gly Met
            180                 185                 190         
Met Gly Ile Asn Ser Tyr Gly Ser Gln Leu Gly Val Ser Ile Ser Glu
        195                 200                 205             
Ser Thr Gln Gly Asn Asn Gln Gly Tyr Ile Arg Asn Thr Ser Ser Ile
    210                 215                 220                 
Ser Pro Arg Gly Tyr Ser Ser Ser Ser Thr Pro Gln Gln Ser Asn Tyr
225                 230                 235                 240 
Ser Thr Ser Ser Asn Ser Met Asn Gly Tyr Ser Asn Val Pro Met Ala
                245                 250                 255     
Asn Leu Gly Val Pro Gly Ser Pro Gly Phe Leu Asn Gly Ser Pro Thr
            260                 265                 270         
Gly Ser Pro Tyr Gly Ile Met Ser Leu Ser Pro Thr Val Gly Ser Ser
        275                 280                 285             
Ser Thr Ser Ser Ile Leu Pro Phe Ser Ser Ser Val Phe Pro Ala Val
    290                 295                 300                 
Lys Gln Lys Ser Ala Phe Ala Pro Val Ile Arg Pro Gln Gly Ser Pro
305                 310                 315                 320 
Ser Pro Ala Cys Ser Ser Gly Asn Gly Asn Gly Phe Arg Ala Met Thr
                325                 330                 335     
Gly Leu Val Val Pro Pro Met
            340             


<210> 7356
<211> 1128
<212> PRT
<213> Homo sapiens

<400> 7356
Met Ile Ala Val Ser Phe Lys Cys Arg Cys Gln Ile Leu Arg Arg Leu
 1               5                  10                  15      
Thr Lys Asp Glu Ser Pro Tyr Thr Lys Ser Ala Ser Gln Thr Lys Pro
            20                  25                  30          
Pro Asp Gly Ala Leu Ala Val Arg Arg Gln Ser Ile Pro Glu Glu Phe
        35                  40                  45              
Lys Gly Ser Thr Val Val Glu Leu Met Lys Lys Glu Gly Thr Thr Leu
    50                  55                  60                  
Gly Leu Thr Val Ser Gly Gly Ile Asp Lys Asp Gly Lys Pro Arg Val
65                  70                  75                  80  
Ser Asn Leu Arg Gln Gly Gly Ile Ala Ala Arg Ser Asp Gln Leu Asp
                85                  90                  95      
Val Gly Asp Tyr Ile Lys Ala Val Asn Gly Ile Asn Leu Ala Lys Phe
            100                 105                 110         
Arg His Asp Glu Ile Ile Ser Leu Leu Lys Asn Val Gly Glu Arg Val
        115                 120                 125             
Val Leu Glu Val Glu Tyr Glu Leu Pro Pro Val Ser Val Gln Gly Ser
    130                 135                 140                 
Ser Val Ile Phe Arg Thr Val Glu Val Thr Leu His Lys Glu Gly Asn
145                 150                 155                 160 
Thr Phe Gly Phe Val Ile Arg Gly Gly Ala His Asp Asp Arg Asn Lys
                165                 170                 175     
Ser Arg Pro Val Val Ile Thr Cys Val Arg Pro Gly Gly Pro Ala Asp
            180                 185                 190         
Arg Glu Gly Thr Ile Lys Pro Gly Asp Arg Leu Leu Ser Val Asp Gly
        195                 200                 205             
Ile Arg Leu Leu Gly Thr Thr His Ala Glu Ala Met Ser Ile Leu Lys
    210                 215                 220                 
Gln Cys Gly Gln Glu Ala Ala Leu Leu Ile Glu Tyr Asp Val Ser Val
225                 230                 235                 240 
Met Asp Ser Val Ala Thr Ala Ser Gly Pro Leu Leu Val Glu Val Ala
                245                 250                 255     
Lys Thr Pro Gly Ala Ser Leu Gly Val Ala Leu Thr Thr Ser Met Cys
            260                 265                 270         
Cys Asn Lys Gln Val Ile Val Ile Asp Lys Ile Lys Ser Ala Ser Ile
        275                 280                 285             
Ala Asp Arg Cys Gly Ala Leu His Val Gly Asp His Ile Leu Ser Ile
    290                 295                 300                 
Asp Gly Thr Ser Met Glu Tyr Cys Thr Leu Ala Glu Ala Thr Gln Phe
305                 310                 315                 320 
Leu Ala Asn Thr Thr Asp Gln Val Lys Leu Glu Ile Leu Pro His His
                325                 330                 335     
Gln Thr Arg Leu Ala Leu Lys Gly Pro Asp His Val Lys Ile Gln Arg
            340                 345                 350         
Ser Asp Arg Gln Leu Thr Trp Asp Ser Trp Ala Ser Asn His Ser Ser
        355                 360                 365             
Leu His Thr Asn His His Tyr Asn Thr Tyr His Pro Asp His Cys Arg
    370                 375                 380                 
Val Pro Ala Leu Thr Phe Pro Lys Ala Pro Pro Pro Asn Ser Pro Pro
385                 390                 395                 400 
Ala Leu Val Ser Ser Ser Phe Ser Pro Thr Ser Met Ser Ala Tyr Ser
                405                 410                 415     
Leu Ser Ser Leu Asn Met Gly Thr Leu Pro Arg Ser Leu Tyr Ser Thr
            420                 425                 430         
Ser Pro Arg Gly Thr Met Met Arg Arg Arg Leu Lys Lys Lys Asp Phe
        435                 440                 445             
Lys Ser Ser Leu Ser Leu Ala Ser Ser Thr Val Gly Leu Ala Gly Gln
    450                 455                 460                 
Val Val His Thr Glu Thr Thr Glu Val Val Leu Thr Ala Asp Pro Val
465                 470                 475                 480 
Thr Gly Phe Gly Ile Gln Leu Gln Gly Ser Val Phe Ala Thr Glu Thr
                485                 490                 495     
Leu Ser Ser Pro Pro Leu Ile Ser Tyr Ile Glu Ala Asp Ser Pro Ala
            500                 505                 510         
Glu Arg Cys Gly Val Leu Gln Ile Gly Asp Arg Val Met Ala Ile Asn
        515                 520                 525             
Gly Ile Pro Thr Glu Asp Ser Thr Phe Glu Glu Ala Ser Gln Leu Leu
    530                 535                 540                 
Arg Asp Ser Ser Ile Thr Ser Lys Val Thr Leu Glu Ile Glu Phe Asp
545                 550                 555                 560 
Val Ala Glu Ser Val Ile Pro Ser Ser Gly Thr Phe His Val Lys Leu
                565                 570                 575     
Pro Lys Lys His Asn Val Glu Leu Gly Ile Thr Ile Ser Ser Pro Ser
            580                 585                 590         
Ser Arg Lys Pro Gly Asp Pro Leu Val Ile Ser Asp Ile Lys Lys Gly
        595                 600                 605             
Ser Val Ala His Arg Thr Gly Thr Leu Glu Leu Gly Asp Lys Leu Leu
    610                 615                 620                 
Ala Ile Asp Asn Ile Arg Leu Asp Asn Cys Ser Met Glu Asp Ala Val
625                 630                 635                 640 
Gln Ile Leu Gln Gln Cys Glu Asp Leu Val Lys Leu Lys Ile Arg Lys
                645                 650                 655     
Asp Glu Asp Asn Ser Asp Glu Gln Glu Ser Ser Gly Ala Ile Ile Tyr
            660                 665                 670         
Thr Val Glu Leu Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr Ile Ser
        675                 680                 685             
Gly Thr Glu Glu Pro Phe Asp Pro Ile Ile Ile Ser Ser Leu Thr Lys
    690                 695                 700                 
Gly Gly Leu Ala Glu Arg Thr Gly Ala Ile His Ile Gly Asp Arg Ile
705                 710                 715                 720 
Leu Ala Ile Asn Ser Ser Ser Leu Lys Gly Lys Pro Leu Ser Glu Ala
                725                 730                 735     
Ile His Leu Leu Gln Met Ala Gly Glu Thr Val Thr Leu Lys Ile Lys
            740                 745                 750         
Lys Gln Thr Asp Ala Gln Ser Ala Ser Ser Pro Lys Lys Phe Pro Ile
        755                 760                 765             
Ser Ser His Leu Ser Asp Leu Gly Asp Val Glu Glu Asp Ser Ser Pro
    770                 775                 780                 
Ala Gln Lys Pro Gly Lys Leu Ser Asp Met Tyr Pro Ser Thr Val Pro
785                 790                 795                 800 
Ser Val Asp Ser Ala Val Asp Ser Trp Asp Gly Ser Ala Ile Asp Thr
                805                 810                 815     
Ser Tyr Gly Thr Gln Gly Thr Ser Phe Gln Ala Ser Gly Tyr Asn Phe
            820                 825                 830         
Asn Thr Tyr Asp Trp Arg Ser Pro Lys Gln Arg Gly Ser Leu Ser Pro
        835                 840                 845             
Val Thr Lys Pro Arg Ser Gln Thr Tyr Pro Asp Val Gly Leu Ser Tyr
    850                 855                 860                 
Glu Asp Trp Asp Arg Ser Thr Ala Ser Gly Phe Ala Gly Ala Ala Asp
865                 870                 875                 880 
Ser Ala Glu Thr Glu Gln Glu Glu Asn Phe Trp Ser Gln Ala Leu Glu
                885                 890                 895     
Asp Leu Glu Thr Cys Gly Gln Ser Gly Ile Leu Arg Glu Leu Glu Glu
            900                 905                 910         
Lys Ala Asp Arg Arg Val Ser Leu Arg Asn Met Thr Leu Leu Ala Thr
        915                 920                 925             
Ile Met Ser Gly Ser Thr Met Ser Leu Asn His Glu Ala Pro Thr Pro
    930                 935                 940                 
Arg Ser Gln Leu Gly Arg Gln Ala Ser Phe Gln Glu Arg Ser Ser Ser
945                 950                 955                 960 
Arg Pro His Tyr Ser Gln Thr Thr Arg Ser Asn Thr Leu Pro Ser Asp
                965                 970                 975     
Val Gly Arg Lys Ser Val Thr Leu Arg Lys Met Lys Gln Glu Ile Lys
            980                 985                 990         
Glu Ile Met Ser Pro Thr Pro Val Glu Leu His Lys Val Thr Leu Tyr
        995                 1000                1005            
Lys Asp Ser Asp Met Glu Asp Phe Gly Phe Ser Val Ala Asp Gly Leu
    1010                1015                1020                
Leu Glu Lys Gly Val Tyr Val Lys Asn Ile Arg Pro Ala Gly Pro Gly
1025                1030                1035                1040
Asp Leu Gly Gly Leu Lys Pro Tyr Asp Arg Leu Leu Gln Val Asn His
                1045                1050                1055    
Val Arg Thr Arg Asp Phe Asp Cys Cys Leu Val Val Pro Leu Ile Ala
            1060                1065                1070        
Glu Ser Gly Asn Lys Leu Asp Leu Val Ile Ser Arg Asn Pro Leu Ala
        1075                1080                1085            
Ser Gln Lys Ser Ile Asp Gln Gln Ser Leu Pro Gly Asp Trp Ser Glu
    1090                1095                1100                
Gln Asn Ser Ala Phe Phe Gln Gln Pro Ser His Gly Gly Asn Leu Glu
1105                1110                1115                1120
Thr Arg Glu Pro Thr Asn Thr Leu
                1125            


<210> 7357
<211> 592
<212> PRT
<213> Homo sapiens

<400> 7357
Met Ala Pro Gly Gln Leu Ala Leu Phe Ser Val Ser Asp Lys Thr Gly
 1               5                  10                  15      
Leu Val Glu Phe Ala Arg Asn Leu Thr Ala Leu Gly Leu Asn Leu Val
            20                  25                  30          
Ala Ser Gly Gly Thr Ala Lys Ala Leu Arg Asp Ala Gly Leu Ala Val
        35                  40                  45              
Arg Asp Val Ser Glu Leu Thr Gly Phe Pro Glu Met Leu Gly Gly Arg
    50                  55                  60                  
Val Lys Thr Leu His Pro Ala Val His Ala Gly Ile Leu Ala Arg Asn
65                  70                  75                  80  
Ile Pro Glu Asp Asn Ala Asp Met Ala Arg Leu Asp Phe Asn Leu Ile
                85                  90                  95      
Arg Val Val Ala Cys Asn Leu Tyr Pro Phe Val Lys Thr Val Ala Ser
            100                 105                 110         
Pro Gly Val Thr Val Glu Glu Ala Val Glu Gln Ile Asp Ile Gly Gly
        115                 120                 125             
Val Thr Leu Leu Arg Ala Ala Ala Lys Asn His Ala Arg Val Thr Val
    130                 135                 140                 
Val Cys Glu Pro Glu Asp Tyr Val Val Val Ser Thr Glu Met Gln Ser
145                 150                 155                 160 
Ser Glu Ser Lys Asp Thr Ser Leu Glu Thr Arg Arg Gln Leu Ala Leu
                165                 170                 175     
Lys Ala Phe Thr His Thr Ala Gln Tyr Asp Glu Ala Ile Ser Asp Tyr
            180                 185                 190         
Phe Arg Lys Gln Tyr Ser Lys Gly Val Ser Gln Met Pro Leu Arg Tyr
        195                 200                 205             
Gly Met Asn Pro His Gln Thr Pro Ala Gln Leu Tyr Thr Leu Gln Pro
    210                 215                 220                 
Lys Leu Pro Ile Thr Val Leu Asn Gly Ala Pro Gly Phe Ile Asn Leu
225                 230                 235                 240 
Cys Asp Ala Leu Asn Ala Trp Gln Leu Val Lys Glu Leu Lys Glu Ala
                245                 250                 255     
Leu Gly Ile Pro Ala Ala Ala Ser Phe Lys His Val Ser Pro Ala Gly
            260                 265                 270         
Ala Ala Val Gly Ile Pro Leu Ser Glu Asp Glu Ala Lys Val Cys Met
        275                 280                 285             
Val Tyr Asp Leu Tyr Lys Thr Leu Thr Pro Ile Ser Ala Ala Tyr Ala
    290                 295                 300                 
Arg Ala Arg Gly Ala Asp Arg Met Ser Ser Phe Gly Asp Phe Val Ala
305                 310                 315                 320 
Leu Ser Asp Val Cys Asp Val Pro Thr Ala Lys Ile Ile Ser Arg Glu
                325                 330                 335     
Val Ser Asp Gly Ile Ile Ala Pro Gly Tyr Glu Glu Glu Ala Leu Thr
            340                 345                 350         
Ile Leu Ser Lys Lys Lys Asn Gly Asn Tyr Cys Val Leu Gln Met Asp
        355                 360                 365             
Gln Ser Tyr Lys Pro Asp Glu Asn Glu Val Arg Thr Leu Phe Gly Leu
    370                 375                 380                 
His Leu Ser Gln Lys Arg Asn Asn Gly Val Val Asp Lys Ser Leu Phe
385                 390                 395                 400 
Ser Asn Val Val Thr Lys Asn Lys Asp Leu Pro Glu Ser Ala Leu Arg
                405                 410                 415     
Asp Leu Ile Val Ala Thr Ile Ala Val Lys Tyr Thr Gln Ser Asn Ser
            420                 425                 430         
Val Cys Tyr Ala Lys Asn Gly Gln Val Ile Gly Ile Gly Ala Gly Gln
        435                 440                 445             
Gln Ser Arg Ile His Cys Thr Arg Leu Ala Gly Asp Lys Ala Asn Tyr
    450                 455                 460                 
Trp Trp Leu Arg His His Pro Gln Val Leu Ser Met Lys Phe Lys Thr
465                 470                 475                 480 
Gly Val Lys Arg Ala Glu Ile Ser Asn Ala Ile Asp Gln Tyr Val Thr
                485                 490                 495     
Gly Thr Ile Gly Glu Asp Glu Asp Leu Ile Lys Trp Lys Ala Leu Phe
            500                 505                 510         
Glu Glu Val Pro Glu Leu Leu Thr Glu Ala Glu Lys Lys Glu Trp Val
        515                 520                 525             
Glu Lys Leu Thr Glu Val Ser Ile Ser Ser Asp Ala Phe Phe Pro Phe
    530                 535                 540                 
Arg Asp Asn Val Asp Arg Ala Lys Arg Ser Gly Val Ala Tyr Ile Ala
545                 550                 555                 560 
Ala Pro Ser Gly Ser Ala Ala Asp Lys Val Val Ile Glu Ala Cys Asp
                565                 570                 575     
Glu Leu Gly Ile Ile Leu Ala His Thr Asn Leu Arg Leu Phe His His
            580                 585                 590         


<210> 7358
<211> 231
<212> PRT
<213> Homo sapiens

<400> 7358
Leu Lys Tyr Val Asp Asp Ile Glu Lys Gly Asn Thr Ile Lys Arg Ile
 1               5                  10                  15      
Pro Ile His Arg Arg Ala Lys Gln Ala Lys Phe Ser Thr Leu Pro Arg
            20                  25                  30          
Asn Phe Ser Leu Pro Asp Ile Cys Glu Glu Asp Pro Gly Ala Pro Ala
        35                  40                  45              
Gly Ala Val Glu Leu Pro Gly Ala Trp Val Pro Gly Ala Gly Gln Arg
    50                  55                  60                  
His Gln Ala Ala Ser Leu Gln Ala Gln Gln His Pro Glu Pro Ala Ala
65                  70                  75                  80  
Glu Leu Pro Gln Pro Ala Ala Val Glu Ile Ser Pro Ser Thr Ser Leu
                85                  90                  95      
Lys Ser Ile Met Lys Lys Lys Asp Tyr Gly Phe Arg Ala Gly Gly Asn
            100                 105                 110         
Gly Thr Lys Lys Asn Leu Gln Phe Val Gly Val Asn Gly Gly Arg Lys
        115                 120                 125             
Ser Ser Ser Pro Ala Val Val Ala Ser Tyr Leu His Glu Val Gln Pro
    130                 135                 140                 
His Ser Pro His Phe Leu Lys Leu Leu Val Asn Leu Ala Asp His Asn
145                 150                 155                 160 
Gly Asn Thr Ala Leu His Tyr Ser Val Ser His Ser Asn Phe Ser Ile
                165                 170                 175     
Val Lys Leu Leu Leu Glu Thr Gly Val Cys Asn Val Asp His Gln Asn
            180                 185                 190         
Lys Ala Gly Tyr Thr Ala Val Met Ile Thr Pro Leu Ala Ser Ala Glu
        195                 200                 205             
Thr Asn Glu Asp Met Ala Val Val Trp Lys Leu Leu Arg Glu Gly Asn
    210                 215                 220                 
Val Asn Ile Gln Ala Thr Gln
225                 230     


<210> 7359
<211> 318
<212> PRT
<213> Homo sapiens

<400> 7359
Met Pro Asn Ile Lys Ile Phe Ser Gly Ser Ser His Gln Asp Leu Ser
 1               5                  10                  15      
Gln Lys Ile Ala Asp Arg Leu Gly Leu Glu Leu Gly Lys Val Val Thr
            20                  25                  30          
Lys Lys Phe Ser Asn Gln Glu Thr Cys Val Glu Ile Gly Glu Ser Val
        35                  40                  45              
Arg Gly Glu Asp Val Tyr Ile Val Gln Ser Gly Cys Gly Glu Ile Asn
    50                  55                  60                  
Asp Asn Leu Met Glu Leu Leu Ile Met Ile Asn Ala Cys Lys Ile Ala
65                  70                  75                  80  
Ser Ala Ser Arg Val Thr Ala Val Ile Pro Cys Phe Pro Tyr Ala Arg
                85                  90                  95      
Gln Asp Lys Lys Asp Lys Ser Arg Ala Pro Ile Ser Ala Lys Leu Val
            100                 105                 110         
Ala Asn Met Leu Ser Val Ala Gly Ala Asp His Ile Ile Thr Met Asp
        115                 120                 125             
Leu His Ala Ser Gln Ile Gln Gly Phe Phe Asp Ile Pro Val Asp Asn
    130                 135                 140                 
Leu Tyr Ala Glu Pro Ala Val Leu Lys Trp Ile Arg Glu Asn Ile Ser
145                 150                 155                 160 
Glu Trp Arg Asn Cys Thr Ile Val Ser Pro Asp Ala Gly Gly Ala Lys
                165                 170                 175     
Arg Val Thr Ser Ile Ala Asp Arg Leu Asn Val Asp Phe Ala Leu Ile
            180                 185                 190         
His Lys Glu Arg Lys Lys Ala Asn Glu Val Asp Arg Met Val Leu Val
        195                 200                 205             
Gly Asp Val Lys Asp Arg Val Ala Ile Leu Val Asp Asp Met Ala Asp
    210                 215                 220                 
Thr Cys Gly Thr Ile Cys His Ala Ala Asp Lys Leu Leu Ser Ala Gly
225                 230                 235                 240 
Ala Thr Arg Val Tyr Ala Ile Leu Thr His Gly Ile Phe Ser Gly Pro
                245                 250                 255     
Ala Ile Ser Arg Ile Asn Asn Ala Cys Phe Glu Ala Val Val Val Thr
            260                 265                 270         
Asn Thr Ile Pro Gln Glu Asp Lys Met Lys His Cys Ser Lys Ile Gln
        275                 280                 285             
Val Ile Asp Ile Ser Met Ile Leu Ala Glu Ala Ile Arg Arg Thr His
    290                 295                 300                 
Asn Gly Glu Ser Val Ser Tyr Leu Phe Ser His Val Pro Leu
305                 310                 315             


<210> 7360
<211> 2004
<212> PRT
<213> Homo sapiens

<400> 7360
Met Val Lys Leu Ala Asn Pro Leu Tyr Thr Glu Trp Ile Leu Glu Ala
 1               5                  10                  15      
Ile Lys Lys Val Lys Lys Gln Lys Gln Arg Pro Ser Glu Glu Arg Ile
            20                  25                  30          
Cys Asn Ala Val Ser Ser Ser His Gly Leu Asp Arg Lys Thr Val Leu
        35                  40                  45              
Glu Gln Leu Glu Leu Ser Val Lys Asp Gly Thr Ile Leu Lys Val Ser
    50                  55                  60                  
Asn Lys Gly Leu Asn Ser Tyr Lys Asp Pro Asp Asn Pro Gly Arg Ile
65                  70                  75                  80  
Ala Leu Pro Lys Pro Arg Asn His Gly Lys Leu Asp Asn Lys Gln Asn
                85                  90                  95      
Val Asp Trp Asn Lys Leu Ile Lys Arg Ala Val Glu Gly Leu Ala Glu
            100                 105                 110         
Ser Gly Gly Ser Thr Leu Lys Ser Ile Glu Arg Phe Leu Lys Gly Gln
        115                 120                 125             
Lys Asp Val Ser Ala Leu Phe Gly Gly Ser Ala Ala Ser Gly Phe His
    130                 135                 140                 
Gln Gln Leu Arg Leu Ala Ile Lys Arg Ala Ile Gly His Gly Arg Leu
145                 150                 155                 160 
Leu Lys Asp Gly Pro Leu Tyr Arg Leu Asn Thr Lys Ala Thr Asn Val
                165                 170                 175     
Asp Gly Lys Glu Ser Cys Glu Ser Leu Ser Cys Leu Pro Pro Val Ser
            180                 185                 190         
Leu Leu Pro His Glu Lys Asp Lys Pro Val Ala Glu Pro Ile Pro Ile
        195                 200                 205             
Cys Ser Phe Cys Leu Gly Thr Lys Glu Gln Asn Arg Glu Lys Lys Pro
    210                 215                 220                 
Glu Glu Leu Ile Ser Cys Ala Asp Cys Gly Asn Ser Gly His Pro Ser
225                 230                 235                 240 
Cys Leu Lys Phe Ser Pro Glu Leu Thr Val Arg Val Lys Ala Leu Arg
                245                 250                 255     
Trp Gln Cys Ile Glu Cys Lys Thr Cys Ser Ser Cys Arg Asp Gln Gly
            260                 265                 270         
Lys Asn Ala Asp Asn Met Leu Phe Cys Asp Ser Cys Asp Arg Gly Phe
        275                 280                 285             
His Met Glu Cys Cys Asp Pro Pro Leu Thr Arg Met Pro Lys Gly Met
    290                 295                 300                 
Trp Ile Cys Gln Ile Cys Arg Pro Arg Lys Lys Gly Arg Lys Leu Leu
305                 310                 315                 320 
Gln Lys Lys Ala Ala Gln Ile Lys Arg Arg Tyr Thr Asn Pro Ile Gly
                325                 330                 335     
Arg Pro Lys Asn Arg Leu Lys Lys Gln Asn Thr Val Ser Lys Gly Pro
            340                 345                 350         
Phe Ser Lys Val Arg Thr Gly Pro Gly Arg Gly Arg Lys Arg Lys Ile
        355                 360                 365             
Thr Leu Ser Ser Gln Ser Ala Ser Ser Ser Ser Glu Glu Gly Tyr Leu
    370                 375                 380                 
Glu Arg Ile Asp Gly Leu Asp Phe Cys Arg Asp Ser Asn Val Ser Leu
385                 390                 395                 400 
Arg Phe Asn Lys Lys Thr Lys Gly Leu Ile Asp Gly Leu Thr Lys Phe
                405                 410                 415     
Phe Thr Pro Ser Pro Asp Gly Arg Lys Ala Arg Gly Glu Val Val Asp
            420                 425                 430         
Tyr Ser Glu Gln Tyr Arg Ile Arg Lys Arg Gly Asn Arg Lys Ser Ser
        435                 440                 445             
Thr Ser Asp Trp Pro Thr Asp Asn Gln Asp Gly Trp Asp Gly Lys Gln
    450                 455                 460                 
Glu Asn Glu Glu Arg Leu Phe Gly Ser Gln Glu Ile Met Thr Glu Lys
465                 470                 475                 480 
Asp Met Glu Leu Phe Arg Asp Ile Gln Glu Gln Ala Leu Gln Lys Val
                485                 490                 495     
Gly Val Thr Gly Pro Pro Asp Pro Gln Val Arg Cys Pro Ser Val Ile
            500                 505                 510         
Glu Phe Gly Lys Tyr Glu Ile His Thr Trp Tyr Ser Ser Pro Tyr Pro
        515                 520                 525             
Gln Glu Tyr Ser Arg Leu Pro Lys Leu Tyr Leu Cys Glu Phe Cys Leu
    530                 535                 540                 
Lys Tyr Met Lys Ser Arg Thr Ile Leu Gln Gln His Met Lys Lys Cys
545                 550                 555                 560 
Gly Trp Phe His Pro Pro Ala Asn Glu Ile Tyr Arg Lys Asn Asn Ile
                565                 570                 575     
Ser Val Phe Glu Val Asp Gly Asn Val Ser Thr Ile Tyr Cys Gln Asn
            580                 585                 590         
Leu Cys Leu Leu Ala Lys Leu Phe Leu Asp His Lys Thr Leu Tyr Tyr
        595                 600                 605             
Asp Val Glu Pro Phe Leu Phe Tyr Val Leu Thr Gln Asn Asp Val Lys
    610                 615                 620                 
Gly Cys His Leu Val Gly Tyr Phe Ser Lys Glu Lys His Cys Gln Gln
625                 630                 635                 640 
Lys Tyr Asn Val Ser Cys Ile Met Ile Leu Pro Gln Tyr Gln Arg Lys
                645                 650                 655     
Gly Tyr Gly Arg Phe Leu Ile Asp Phe Ser Tyr Leu Leu Ser Lys Arg
            660                 665                 670         
Glu Gly Gln Ala Gly Ser Pro Glu Lys Pro Leu Ser Asp Leu Gly Arg
        675                 680                 685             
Leu Ser Tyr Met Ala Tyr Trp Lys Ser Val Ile Leu Glu Cys Leu Tyr
    690                 695                 700                 
His Gln Asn Asp Lys Gln Ile Ser Ile Lys Lys Leu Ser Lys Leu Thr
705                 710                 715                 720 
Gly Ile Cys Pro Gln Asp Ile Thr Ser Thr Leu His His Leu Arg Met
                725                 730                 735     
Leu Asp Phe Arg Ser Asp Gln Phe Val Ile Ile Arg Arg Glu Lys Leu
            740                 745                 750         
Ile Gln Asp His Met Ala Lys Leu Gln Leu Asn Leu Arg Pro Val Asp
        755                 760                 765             
Val Asp Pro Glu Cys Leu Arg Trp Thr Pro Val Ile Val Ser Asn Ser
    770                 775                 780                 
Val Val Ser Glu Glu Glu Glu Glu Glu Ala Glu Glu Gly Glu Asn Glu
785                 790                 795                 800 
Glu Pro Gln Cys Gln Glu Arg Glu Leu Glu Ile Ser Val Gly Lys Ser
                805                 810                 815     
Val Ser His Glu Asn Lys Glu Gln Asp Ser Tyr Ser Val Glu Ser Glu
            820                 825                 830         
Lys Lys Pro Glu Val Met Ala Pro Val Ser Ser Thr Arg Leu Ser Lys
        835                 840                 845             
Gln Val Leu Pro His Asp Ser Leu Pro Ala Asn Ser Gln Pro Ser Arg
    850                 855                 860                 
Arg Gly Arg Trp Gly Arg Lys Asn Arg Lys Thr Gln Glu Arg Phe Gly
865                 870                 875                 880 
Asp Lys Asp Ser Lys Leu Leu Leu Glu Glu Thr Ser Ser Ala Pro Gln
                885                 890                 895     
Glu Gln Tyr Gly Glu Cys Gly Glu Lys Ser Glu Ala Thr Gln Glu Gln
            900                 905                 910         
Tyr Thr Glu Ser Glu Glu Gln Leu Val Ala Ser Glu Glu Gln Pro Ser
        915                 920                 925             
Gln Asp Gly Lys Pro Asp Leu Pro Lys Arg Arg Leu Ser Glu Gly Val
    930                 935                 940                 
Glu Pro Trp Arg Gly Gln Leu Lys Lys Ser Pro Glu Ala Leu Lys Cys
945                 950                 955                 960 
Arg Leu Thr Glu Gly Ser Glu Arg Leu Pro Arg Arg Tyr Ser Glu Gly
                965                 970                 975     
Asp Arg Ala Val Leu Arg Gly Phe Ser Glu Ser Ser Glu Glu Glu Glu
            980                 985                 990         
Glu Pro Glu Ser Pro Arg Ser Ser Ser Pro Pro Ile Leu Thr Lys Pro
        995                 1000                1005            
Thr Leu Lys Arg Lys Lys Pro Phe Leu His Arg Arg Arg Arg Val Arg
    1010                1015                1020                
Lys Arg Lys His His Asn Ser Ser Val Val Thr Glu Thr Ile Ser Glu
1025                1030                1035                1040
Thr Thr Glu Val Leu Asp Glu Pro Phe Glu Asp Ser Asp Ser Glu Arg
                1045                1050                1055    
Pro Met Pro Arg Leu Glu Pro Thr Phe Glu Ile Asp Glu Glu Glu Glu
            1060                1065                1070        
Glu Glu Asp Glu Asn Glu Leu Phe Pro Arg Glu Tyr Phe Arg Arg Leu
        1075                1080                1085            
Ser Ser Gln Asp Val Leu Arg Cys Gln Ser Ser Ser Lys Arg Lys Ser
    1090                1095                1100                
Lys Asp Glu Glu Glu Asp Glu Glu Ser Asp Asp Ala Asp Asp Thr Pro
1105                1110                1115                1120
Ile Leu Lys Pro Val Ser Leu Leu Arg Lys Arg Asp Val Lys Asn Ser
                1125                1130                1135    
Pro Leu Glu Pro Asp Thr Ser Thr Pro Leu Lys Lys Lys Lys Gly Trp
            1140                1145                1150        
Pro Lys Gly Lys Ser Arg Lys Pro Ile His Trp Lys Lys Arg Pro Gly
        1155                1160                1165            
Arg Lys Pro Gly Phe Lys Leu Ser Arg Glu Ile Met Pro Val Ser Thr
    1170                1175                1180                
Gln Ala Cys Val Ile Glu Pro Ile Val Ser Ile Pro Lys Ala Gly Arg
1185                1190                1195                1200
Lys Pro Lys Ile Gln Glu Ser Glu Glu Thr Val Glu Pro Lys Glu Asp
                1205                1210                1215    
Met Pro Leu Pro Glu Glu Arg Lys Glu Glu Glu Glu Met Gln Ala Glu
            1220                1225                1230        
Ala Glu Glu Ala Glu Glu Gly Glu Glu Glu Asp Ala Ala Ser Ser Glu
        1235                1240                1245            
Val Pro Ala Ala Ser Pro Ala Asp Ser Ser Asn Ser Pro Glu Thr Glu
    1250                1255                1260                
Thr Lys Glu Pro Glu Val Glu Glu Glu Glu Glu Lys Pro Arg Val Ser
1265                1270                1275                1280
Glu Glu Gln Arg Gln Ser Glu Glu Glu Gln Gln Glu Leu Glu Glu Pro
                1285                1290                1295    
Glu Pro Glu Glu Glu Glu Asp Ala Ala Ala Glu Thr Ala Gln Asn Asp
            1300                1305                1310        
Asp His Asp Ala Asp Asp Glu Asp Asp Gly His Leu Glu Ser Thr Lys
        1315                1320                1325            
Lys Lys Glu Leu Glu Glu Gln Pro Thr Arg Glu Asp Val Lys Glu Glu
    1330                1335                1340                
Pro Gly Val Gln Glu Ser Phe Leu Asp Ala Asn Met Gln Lys Ser Arg
1345                1350                1355                1360
Glu Lys Ile Lys Asp Lys Glu Glu Thr Glu Leu Asp Ser Glu Glu Glu
                1365                1370                1375    
Gln Pro Ser His Asp Thr Ser Val Val Ser Glu Gln Met Ala Gly Ser
            1380                1385                1390        
Glu Asp Asp His Glu Glu Asp Ser His Thr Lys Glu Glu Leu Ile Glu
        1395                1400                1405            
Leu Lys Glu Glu Glu Glu Ile Pro His Ser Glu Leu Asp Leu Glu Thr
    1410                1415                1420                
Val Gln Ala Val Gln Ser Leu Thr Gln Glu Glu Ser Ser Glu His Glu
1425                1430                1435                1440
Gly Ala Tyr Gln Asp Cys Glu Glu Thr Leu Ala Ala Cys Gln Thr Leu
                1445                1450                1455    
Gln Ser Tyr Thr Gln Ala Asp Glu Asp Pro Gln Met Ser Met Val Glu
            1460                1465                1470        
Asp Cys His Ala Ser Glu His Asn Ser Pro Ile Ser Ser Val Gln Ser
        1475                1480                1485            
His Pro Ser Gln Ser Val Arg Ser Val Ser Ser Pro Asn Val Pro Ala
    1490                1495                1500                
Leu Glu Ser Gly Tyr Thr Gln Ile Ser Pro Glu Gln Gly Ser Leu Ser
1505                1510                1515                1520
Ala Pro Ser Met Gln Asn Met Glu Thr Ser Pro Met Met Asp Val Pro
                1525                1530                1535    
Ser Val Ser Asp His Ser Gln Gln Val Val Asp Ser Gly Phe Ser Asp
            1540                1545                1550        
Leu Gly Ser Ile Glu Ser Thr Thr Glu Asn Tyr Glu Asn Pro Ser Ser
        1555                1560                1565            
Tyr Asp Ser Thr Met Gly Gly Ser Ile Cys Gly Asn Ser Ser Ser Gln
    1570                1575                1580                
Ser Ser Cys Ser Tyr Gly Gly Leu Ser Ser Ser Ser Ser Leu Thr Gln
1585                1590                1595                1600
Ser Ser Cys Val Val Thr Gln Gln Met Ala Ser Met Gly Ser Ser Cys
                1605                1610                1615    
Ser Met Met Gln Gln Ser Ser Val Gln Pro Ala Ala Asn Cys Ser Ile
            1620                1625                1630        
Lys Ser Pro Gln Ser Cys Val Val Glu Arg Pro Pro Ser Asn Gln Gln
        1635                1640                1645            
Gln Gln Pro Pro Pro Pro Pro Pro Gln Gln Pro Gln Pro Pro Pro Pro
    1650                1655                1660                
Gln Pro Gln Pro Ala Pro Gln Pro Pro Pro Pro Gln Gln Gln Pro Gln
1665                1670                1675                1680
Gln Gln Pro Gln Pro Gln Pro Gln Gln Pro Pro Pro Pro Pro Pro Pro
                1685                1690                1695    
Gln Gln Gln Pro Pro Leu Ser Gln Cys Ser Met Asn Asn Ser Phe Thr
            1700                1705                1710        
Pro Ala Pro Met Ile Met Glu Ile Pro Glu Ser Gly Ser Thr Gly Asn
        1715                1720                1725            
Ile Ser Ile Tyr Glu Arg Ile Pro Gly Asp Phe Gly Ala Gly Ser Tyr
    1730                1735                1740                
Ser Gln Pro Ser Ala Thr Phe Ser Leu Ala Lys Leu Gln Gln Leu Thr
1745                1750                1755                1760
Asn Thr Ile Met Asp Pro His Ala Met Pro Tyr Ser His Ser Pro Ala
                1765                1770                1775    
Val Thr Ser Tyr Ala Thr Ser Val Ser Leu Ser Asn Thr Gly Leu Ala
            1780                1785                1790        
Gln Leu Ala Pro Ser His Pro Leu Ala Gly Thr Pro Gln Ala Gln Ala
        1795                1800                1805            
Thr Met Thr Pro Pro Pro Asn Leu Ala Ser Thr Thr Met Asn Leu Thr
    1810                1815                1820                
Ser Pro Leu Leu Gln Cys Asn Met Ser Ala Thr Asn Ile Gly Ile Pro
1825                1830                1835                1840
His Thr Gln Arg Leu Gln Gly Gln Met Pro Val Lys Gly His Ile Ser
                1845                1850                1855    
Ile Arg Ser Lys Ser Ala Pro Leu Pro Ser Ala Ala Ala His Gln Gln
            1860                1865                1870        
Gln Leu Tyr Gly Arg Ser Pro Ser Ala Val Ala Met Gln Ala Gly Pro
        1875                1880                1885            
Arg Ala Leu Ala Val Gln Arg Gly Met Asn Met Gly Val Asn Leu Met
    1890                1895                1900                
Pro Thr Pro Ala Tyr Asn Val Asn Ser Met Asn Met Asn Thr Leu Asn
1905                1910                1915                1920
Ala Met Asn Ser Tyr Arg Met Thr Gln Pro Met Met Asn Ser Ser Tyr
                1925                1930                1935    
His Ser Asn Pro Ala Tyr Met Asn Gln Thr Ala Gln Tyr Pro Met Gln
            1940                1945                1950        
Met Gln Met Gly Met Met Gly Ser Gln Ala Tyr Thr Gln Gln Pro Met
        1955                1960                1965            
Gln Pro Asn Pro His Gly Asn Met Met Tyr Thr Gly Pro Ser His His
    1970                1975                1980                
Ser Tyr Met Asn Ala Ala Gly Val Pro Lys Gln Ser Leu Asn Gly Pro
1985                1990                1995                2000
Tyr Met Arg Arg
                


<210> 7361
<211> 524
<212> PRT
<213> Homo sapiens

<400> 7361
Met His Val Glu Thr Gly Pro Asn Gly Glu Gln Ile Arg Lys His Ala
 1               5                  10                  15      
Gly Gln Lys Arg Thr Tyr Lys Ala Ile Ser Glu Ser Tyr Ala Phe Leu
            20                  25                  30          
Pro Arg Glu Ala Val Thr Arg Phe Leu Met Ser Cys Ser Glu Cys Gln
        35                  40                  45              
Lys Arg Met His Leu Asn Pro Asp Gly Thr Asp His Lys Asp Asn Gly
    50                  55                  60                  
Lys Pro Pro Thr Leu Val Thr Ser Met Ile Asp Tyr Asn Met Pro Ile
65                  70                  75                  80  
Thr Met Ala Tyr Met Lys His Met Lys Leu Gln Leu Leu Asn Ser Gln
                85                  90                  95      
Gln Asp Glu Asp Glu Ser Ser Ile Glu Ser Asp Glu Phe Asp Met Ser
            100                 105                 110         
Asp Ser Thr Arg Met Ser Ala Val Asn Ser Asp Leu Ser Ser Asn Leu
        115                 120                 125             
Glu Glu Arg Met Gln Ser Pro Gln Asn Leu His Gly Gln Gln Asp Asp
    130                 135                 140                 
Asp Ser Ala Ala Glu Ser Phe Asn Gly Asn Glu Thr Leu Gly His Ser
145                 150                 155                 160 
Ser Ile Ala Ser Gly Gly Thr His Ser Arg Glu Met Gly Asp Ser Asn
                165                 170                 175     
Ser Asp Gly Lys Thr Gly Leu Glu Gln Asp Glu Gln Pro Leu Asn Leu
            180                 185                 190         
Ser Asp Ser Pro Leu Ser Ala Gln Leu Thr Ser Glu Tyr Arg Ile Asp
        195                 200                 205             
Asp His Asn Ser Asn Gly Lys Asn Lys Tyr Lys Asn Leu Leu Ile Ser
    210                 215                 220                 
Asp Leu Lys Met Glu Arg Glu Ala Arg Glu Asn Gly Ser Lys Ser Pro
225                 230                 235                 240 
Ala His Ser Tyr Ser Ser Tyr Asp Ser Gly Lys Asn Glu Ser Val Asp
                245                 250                 255     
Arg Gly Ala Glu Asp Leu Ser Leu Asn Arg Gly Asp Glu Asp Glu Asp
            260                 265                 270         
Asp His Glu Asp His Asp Asp Ser Glu Lys Val Asn Glu Thr Asp Gly
        275                 280                 285             
Val Glu Ala Glu Arg Leu Lys Ala Phe Asn Met Phe Val Arg Leu Phe
    290                 295                 300                 
Val Asp Glu Asn Leu Asp Arg Met Val Pro Ile Ser Lys Gln Pro Lys
305                 310                 315                 320 
Glu Lys Ile Gln Ala Ile Ile Asp Ser Cys Arg Arg Gln Phe Pro Glu
                325                 330                 335     
Tyr Gln Glu Arg Ala Arg Lys Arg Ile Arg Thr Tyr Leu Lys Ser Cys
            340                 345                 350         
Arg Arg Met Lys Arg Ser Gly Phe Glu Met Ser Arg Pro Ile Pro Ser
        355                 360                 365             
His Leu Thr Ser Ala Val Ala Glu Ser Ile Leu Ala Ser Ala Cys Glu
    370                 375                 380                 
Ser Glu Ser Arg Asn Ala Ala Lys Arg Met Arg Leu Glu Arg Gln Gln
385                 390                 395                 400 
Asp Glu Ser Ala Pro Ala Asp Lys Gln Cys Lys Pro Glu Ala Thr Gln
                405                 410                 415     
Ala Thr Tyr Ser Thr Ser Ala Val Pro Gly Ser Gln Asp Val Leu Tyr
            420                 425                 430         
Ile Asn Gly Asn Gly Thr Tyr Ser Tyr His Ser Tyr Arg Gly Leu Gly
        435                 440                 445             
Gly Gly Leu Leu Asn Leu Asn Asp Ala Ser Ser Ser Gly Pro Thr Asp
    450                 455                 460                 
Leu Ser Met Lys Arg Gln Leu Ala Thr Ser Ser Gly Ser Ser Ser Ser
465                 470                 475                 480 
Ser Asn Ser Arg Pro Gln Leu Ser Pro Thr Glu Ile Asn Ala Val Arg
                485                 490                 495     
Gln Leu Val Ala Gly Tyr Arg Glu Ser Ala Ala Phe Leu Leu Arg Ser
            500                 505                 510         
Ala Asp Glu Leu Glu Asn Leu Ile Leu Gln Gln Asn
        515                 520                 


<210> 7362
<211> 422
<212> PRT
<213> Homo sapiens

<400> 7362
Met His Val Glu Thr Gly Pro Asn Gly Glu Gln Ile Arg Lys His Ala
 1               5                  10                  15      
Gly Gln Lys Arg Thr Tyr Lys Ala Ile Ser Glu Ser Tyr Ala Phe Leu
            20                  25                  30          
Pro Arg Glu Ala Val Thr Arg Phe Leu Met Ser Cys Ser Glu Cys Gln
        35                  40                  45              
Lys Arg Met His Leu Asn Pro Asp Gly Thr Asp His Lys Asp Asn Gly
    50                  55                  60                  
Lys Pro Pro Thr Leu Val Thr Ser Met Ile Asp Tyr Asn Met Pro Ile
65                  70                  75                  80  
Thr Met Ala Tyr Met Lys His Met Lys Leu Gln Leu Leu Asn Ser Gln
                85                  90                  95      
Gln Asp Glu Asp Glu Ser Ser Ile Glu Ser Asp Glu Phe Asp Met Ser
            100                 105                 110         
Asp Ser Thr Arg Met Ser Ala Val Asn Ser Asp Leu Ser Ser Asn Leu
        115                 120                 125             
Glu Glu Arg Met Gln Ser Pro Gln Asn Leu His Gly Gln Gln Asp Asp
    130                 135                 140                 
Asp Ser Ala Ala Glu Ser Phe Asn Gly Asn Glu Thr Leu Gly His Ser
145                 150                 155                 160 
Ser Ile Ala Ser Gly Gly Thr His Ser Arg Glu Met Gly Asp Ser Asn
                165                 170                 175     
Ser Asp Gly Lys Thr Gly Leu Glu Gln Asp Glu Gln Pro Leu Asn Leu
            180                 185                 190         
Ser Asp Ser Pro Leu Ser Ala Gln Leu Thr Ser Glu Tyr Arg Ile Asp
        195                 200                 205             
Asp His Asn Ser Asn Gly Lys Asn Lys Tyr Lys Asn Leu Leu Ile Ser
    210                 215                 220                 
Asp Leu Lys Met Glu Arg Glu Ala Arg Glu Asn Gly Ser Lys Ser Pro
225                 230                 235                 240 
Ala His Ser Tyr Ser Ser Tyr Asp Ser Gly Lys Asn Glu Ser Val Asp
                245                 250                 255     
Arg Gly Ala Glu Asp Leu Ser Leu Asn Arg Gly Asp Glu Asp Glu Asp
            260                 265                 270         
Asp His Glu Asp His Asp Asp Ser Glu Lys Val Asn Glu Thr Asp Gly
        275                 280                 285             
Val Glu Ala Glu Arg Leu Lys Ala Phe Asn Asp Glu Ser Ala Pro Ala
    290                 295                 300                 
Asp Lys Gln Cys Lys Pro Glu Ala Thr Gln Ala Thr Tyr Ser Thr Ser
305                 310                 315                 320 
Ala Val Pro Gly Ser Gln Asp Val Leu Tyr Ile Asn Gly Asn Gly Thr
                325                 330                 335     
Tyr Ser Tyr His Ser Tyr Arg Gly Leu Gly Gly Gly Leu Leu Asn Leu
            340                 345                 350         
Asn Asp Ala Ser Ser Ser Gly Pro Thr Asp Leu Ser Met Lys Arg Gln
        355                 360                 365             
Leu Ala Thr Ser Ser Gly Ser Ser Ser Ser Ser Asn Ser Arg Pro Gln
    370                 375                 380                 
Leu Ser Pro Thr Glu Ile Asn Ala Val Arg Gln Leu Val Ala Gly Tyr
385                 390                 395                 400 
Arg Glu Ser Ala Ala Phe Leu Leu Arg Ser Ala Asp Glu Leu Glu Asn
                405                 410                 415     
Leu Ile Leu Gln Gln Asn
            420         


<210> 7363
<211> 2969
<212> PRT
<213> Homo sapiens

<400> 7363
Met Asp Pro Arg Asn Thr Ala Met Leu Gly Leu Gly Ser Asp Ser Glu
 1               5                  10                  15      
Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Thr Gly Thr Leu Val
            20                  25                  30          
Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Thr Lys Glu Glu Glu Asp
        35                  40                  45              
Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Ala Gly Lys Asp Asp
    50                  55                  60                  
Gly Leu Thr Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Thr Asn Phe
65                  70                  75                  80  
Ser Glu Gly Asn Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Thr
                85                  90                  95      
Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile
            100                 105                 110         
Lys Thr Thr Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met
        115                 120                 125             
Thr Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Asp Pro Ser Lys
    130                 135                 140                 
Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu Cys Gln Ser Glu
145                 150                 155                 160 
Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn Pro Leu Ser Lys
                165                 170                 175     
Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr Ile Asn Ala Thr
            180                 185                 190         
Pro Ser Thr Leu Leu Gly Ser Arg Asp Pro Asp Leu Lys Asp Arg Ala
        195                 200                 205             
Leu Leu Asn Gly Gly Thr Ser Val Thr Glu Lys Leu Ala Gln Leu Ile
    210                 215                 220                 
Ala Thr Cys Pro Pro Ser Lys Ser Ser Lys Thr Lys Pro Lys Lys Leu
225                 230                 235                 240 
Gly Thr Gly Thr Thr Ala Gly Leu Val Ser Lys Asp Leu Ile Arg Lys
                245                 250                 255     
Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys Asp Leu Ile Lys
            260                 265                 270         
Lys Pro Thr Ile Ser Thr Ala Val Gly Leu Val Thr Lys Asp Pro Gly
        275                 280                 285             
Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val Asn Lys Asp Ser
    290                 295                 300                 
Val Lys Lys Leu Gly Thr Gly Thr Thr Ala Val Phe Ile Asn Lys Asn
305                 310                 315                 320 
Leu Gly Lys Lys Pro Gly Thr Ile Thr Thr Val Gly Leu Leu Ser Lys
                325                 330                 335     
Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro Gly Leu Val His
            340                 345                 350         
Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Thr Val Val Gly Leu Val
        355                 360                 365             
Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Thr Val Gly Leu Val Ala
    370                 375                 380                 
Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala Met Gly Leu Val
385                 390                 395                 400 
Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro Leu Ala Gly Leu
                405                 410                 415     
Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala Leu Leu Pro Thr
            420                 425                 430         
Gln Glu Pro Leu Lys Ala Ser Cys Ser Thr Asn Ile Asn Asn Gln Glu
        435                 440                 445             
Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala Thr Ser Lys Thr
    450                 455                 460                 
Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser Ile Leu Glu Lys
465                 470                 475                 480 
Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys Glu Met Phe Asn
                485                 490                 495     
Glu Gly Thr Cys Ile Gln Gln Asp Ser Phe Ser Ser Ser Glu Lys Gly
            500                 505                 510         
Ser Tyr Glu Thr Ser Lys His Glu Lys Gln Pro Pro Val Tyr Cys Thr
        515                 520                 525             
Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val Ser Thr Ala Lys
    530                 535                 540                 
Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro Ser Pro Ser Pro
545                 550                 555                 560 
Thr Val Ser Val Asn Pro Leu Thr Arg Ser Pro Pro Glu Thr Ser Ser
                565                 570                 575     
Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Thr Thr Glu Leu Ile
            580                 585                 590         
Glu Glu Ile Ser Glu Ser Val Gly Lys Asn Gln Phe Thr Ser Glu Ser
        595                 600                 605             
Thr His Leu Asn Val Gly His Arg Ser Val Gly His Ser Ile Ser Ile
    610                 615                 620                 
Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser Lys Thr Thr His
625                 630                 635                 640 
Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys Lys Pro Ser Leu
                645                 650                 655     
Thr Ser Glu Ser Ser Ile His Thr Ile Thr Pro Ser Val Val Asn Phe
            660                 665                 670         
Thr Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu Gly Ala Val Ser
        675                 680                 685             
Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu Ser Thr Ser Leu
    690                 695                 700                 
Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys Pro Arg Trp Thr
705                 710                 715                 720 
Lys Val Val Ala Arg Ser Thr Cys Arg Ser Pro Lys Gly Leu Glu Leu
                725                 730                 735     
Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser Ser Leu Ser Asn
            740                 745                 750         
Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile Gly Pro Pro Ser
        755                 760                 765             
Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro Lys Leu Ser Lys
    770                 775                 780                 
Ser Thr Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser Glu Lys Pro Ser
785                 790                 795                 800 
His Lys Ser Phe Ala Thr His Lys Leu Ser Ser Ser Met Cys Val Ser
                805                 810                 815     
Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg Gly Arg Pro Lys
            820                 825                 830         
Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys Arg Thr Leu Lys
        835                 840                 845             
Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys Glu Glu Gln Glu
    850                 855                 860                 
Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser Phe Lys Gln Gly
865                 870                 875                 880 
Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg Pro Lys Arg Gln
                885                 890                 895     
Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu Ser Val Ala Pro
            900                 905                 910         
Phe Val Ala Thr Glu Ser Pro Ser Lys Leu Glu Ser Glu Ser Asp Asn
        915                 920                 925             
His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp Gln Leu Gln Asp
    930                 935                 940                 
Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val Cys Ser Met Ser
945                 950                 955                 960 
Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Thr Lys Arg Asn Asn Gly
                965                 970                 975     
Gln Leu Met Lys Thr Ile Ile Arg Lys Ile Asn Lys Met Lys Thr Leu
            980                 985                 990         
Lys Arg Lys Lys Leu Leu Asn Gln Ile Leu Ser Ser Ser Val Glu Ser
        995                 1000                1005            
Ser Asn Lys Gly Lys Val Gln Ser Lys Leu His Asn Thr Val Ser Ser
    1010                1015                1020                
Leu Ala Ala Thr Phe Gly Ser Lys Leu Gly Gln Gln Ile Asn Val Ser
1025                1030                1035                1040
Lys Lys Gly Thr Ile Tyr Ile Gly Lys Arg Arg Gly Arg Lys Pro Lys
                1045                1050                1055    
Thr Val Leu Asn Gly Ile Leu Ser Gly Ser Pro Thr Ser Leu Ala Val
            1060                1065                1070        
Leu Glu Gln Thr Ala Gln Gln Ala Ala Gly Ser Ala Leu Gly Gln Ile
        1075                1080                1085            
Leu Pro Pro Leu Leu Pro Ser Ser Ala Ser Ser Ser Glu Ile Leu Pro
    1090                1095                1100                
Ser Pro Ile Cys Ser Gln Ser Ser Gly Thr Ser Gly Gly Gln Ser Pro
1105                1110                1115                1120
Val Ser Ser Asp Ala Gly Phe Val Glu Pro Ser Ser Val Pro Tyr Leu
                1125                1130                1135    
His Leu His Ser Arg Gln Gly Ser Met Ile Gln Thr Leu Ala Met Lys
            1140                1145                1150        
Lys Ala Ser Lys Gly Arg Arg Arg Leu Ser Pro Pro Thr Leu Leu Pro
        1155                1160                1165            
Asn Ser Pro Ser His Leu Ser Glu Leu Thr Ser Leu Lys Glu Ala Thr
    1170                1175                1180                
Pro Ser Pro Ile Ser Glu Ser His Ser Asp Glu Thr Ile Pro Ser Asp
1185                1190                1195                1200
Ser Gly Ile Gly Thr Asp Asn Asn Ser Thr Ser Asp Arg Ala Glu Lys
                1205                1210                1215    
Phe Cys Gly Gln Lys Lys Arg Arg His Ser Phe Glu His Val Ser Leu
            1220                1225                1230        
Ile Pro Pro Glu Thr Ser Thr Val Leu Ser Ser Leu Lys Glu Lys His
        1235                1240                1245            
Lys His Lys Cys Lys Arg Arg Asn His Asp Tyr Leu Ser Tyr Asp Lys
    1250                1255                1260                
Met Lys Arg Gln Lys Arg Lys Arg Lys Lys Lys Tyr Pro Gln Leu Arg
1265                1270                1275                1280
Asn Arg Gln Asp Pro Asp Phe Ile Ala Glu Leu Glu Glu Leu Ile Ser
                1285                1290                1295    
Arg Leu Ser Glu Ile Arg Ile Thr His Arg Ser His His Phe Ile Pro
            1300                1305                1310        
Arg Asp Leu Leu Pro Thr Ile Phe Arg Ile Asn Phe Asn Ser Phe Tyr
        1315                1320                1325            
Thr His Pro Ser Phe Pro Leu Asp Pro Leu His Tyr Ile Arg Lys Pro
    1330                1335                1340                
Asp Leu Lys Lys Lys Arg Gly Arg Pro Pro Lys Met Arg Glu Ala Met
1345                1350                1355                1360
Ala Glu Met Pro Phe Met His Ser Leu Ser Phe Pro Leu Ser Ser Thr
                1365                1370                1375    
Gly Phe Tyr Pro Ser Tyr Gly Met Pro Tyr Ser Pro Ser Pro Leu Thr
            1380                1385                1390        
Ala Ala Pro Ile Gly Leu Gly Tyr Tyr Gly Arg Tyr Pro Pro Thr Leu
        1395                1400                1405            
Tyr Pro Pro Pro Pro Ser Pro Ser Phe Thr Thr Pro Leu Pro Pro Pro
    1410                1415                1420                
Ser Tyr Met His Ala Gly His Leu Leu Leu Asn Pro Ala Lys Tyr His
1425                1430                1435                1440
Lys Lys Lys His Lys Leu Leu Arg Gln Glu Ala Phe Leu Thr Thr Ser
                1445                1450                1455    
Arg Thr Pro Leu Leu Ser Met Ser Thr Tyr Pro Ser Val Pro Pro Glu
            1460                1465                1470        
Met Ala Tyr Gly Trp Met Val Glu His Lys His Arg His Arg His Lys
        1475                1480                1485            
His Arg Glu His Arg Ser Ser Glu Gln Pro Gln Val Ser Met Asp Thr
    1490                1495                1500                
Gly Ser Ser Arg Ser Val Leu Glu Ser Leu Lys Arg Tyr Arg Phe Gly
1505                1510                1515                1520
Lys Asp Ala Val Gly Glu Arg Tyr Lys His Lys Glu Lys His Arg Cys
                1525                1530                1535    
His Met Ser Cys Pro His Leu Ser Pro Ser Lys Ser Leu Ile Asn Arg
            1540                1545                1550        
Glu Glu Gln Trp Val His Arg Glu Pro Ser Glu Ser Ser Pro Leu Ala
        1555                1560                1565            
Leu Gly Leu Gln Thr Pro Leu Gln Ile Asp Cys Ser Glu Ser Ser Pro
    1570                1575                1580                
Ser Leu Ser Leu Gly Gly Phe Thr Pro Asn Ser Glu Pro Ala Ser Ser
1585                1590                1595                1600
Asp Glu His Thr Asn Leu Phe Thr Ser Ala Ile Gly Ser Cys Arg Val
                1605                1610                1615    
Ser Asn Pro Asn Ser Ser Gly Arg Lys Lys Leu Thr Asp Ser Pro Gly
            1620                1625                1630        
Leu Phe Ser Ala Gln Asp Thr Ser Leu Asn Arg Leu His Arg Lys Glu
        1635                1640                1645            
Ser Leu Pro Ser Asn Glu Arg Ala Val Gln Thr Leu Ala Gly Ser Gln
    1650                1655                1660                
Pro Thr Ser Asp Lys Pro Ser Gln Arg Pro Ser Glu Ser Thr Asn Cys
1665                1670                1675                1680
Ser Pro Thr Arg Lys Arg Ser Ser Ser Glu Ser Thr Ser Ser Thr Val
                1685                1690                1695    
Asn Gly Val Pro Ser Arg Ser Pro Arg Leu Val Ala Ser Gly Asp Asp
            1700                1705                1710        
Ser Val Asp Ser Leu Leu Gln Arg Met Val Gln Asn Glu Asp Gln Glu
        1715                1720                1725            
Pro Met Glu Lys Ser Ile Asp Ala Val Ile Ala Thr Ala Ser Ala Pro
    1730                1735                1740                
Pro Ser Ser Ser Pro Gly Arg Ser His Ser Lys Asp Arg Thr Leu Gly
1745                1750                1755                1760
Lys Pro Asp Ser Leu Leu Val Pro Ala Val Ala Ser Asp Ser Cys Asn
                1765                1770                1775    
Asn Ser Ile Ser Leu Leu Ser Glu Lys Leu Thr Ser Ser Cys Ser Pro
            1780                1785                1790        
His His Ile Lys Arg Ser Val Val Glu Ala Met Gln Arg Gln Ala Arg
        1795                1800                1805            
Lys Met Cys Asn Tyr Asp Lys Ile Leu Ala Thr Lys Lys Asn Leu Asp
    1810                1815                1820                
His Val Asn Lys Ile Leu Lys Ala Lys Lys Leu Gln Arg Gln Ala Arg
1825                1830                1835                1840
Thr Gly Asn Asn Phe Val Lys Arg Arg Pro Gly Arg Pro Arg Lys Cys
                1845                1850                1855    
Pro Leu Gln Ala Val Val Ser Met Gln Ala Phe Gln Ala Ala Gln Phe
            1860                1865                1870        
Val Asn Pro Glu Leu Asn Arg Asp Glu Glu Gly Ala Ala Leu His Leu
        1875                1880                1885            
Ser Pro Asp Thr Val Thr Asp Val Ile Glu Ala Val Val Gln Ser Val
    1890                1895                1900                
Asn Leu Asn Pro Glu His Lys Lys Gly Leu Lys Arg Lys Gly Trp Leu
1905                1910                1915                1920
Leu Glu Glu Gln Thr Arg Lys Lys Gln Lys Pro Leu Pro Glu Glu Glu
                1925                1930                1935    
Glu Gln Glu Asn Asn Lys Ser Phe Asn Glu Ala Pro Val Glu Ile Pro
            1940                1945                1950        
Ser Pro Ser Glu Thr Pro Ala Lys Pro Ser Glu Pro Glu Ser Thr Leu
        1955                1960                1965            
Gln Pro Val Leu Ser Leu Ile Pro Arg Glu Lys Lys Pro Pro Arg Pro
    1970                1975                1980                
Pro Lys Lys Lys Tyr Gln Lys Ala Gly Leu Tyr Ser Asp Val Tyr Lys
1985                1990                1995                2000
Thr Thr Asp Pro Lys Ser Arg Leu Ile Gln Leu Lys Lys Glu Lys Leu
                2005                2010                2015    
Glu Tyr Thr Pro Gly Glu His Glu Tyr Gly Leu Phe Pro Ala Pro Ile
            2020                2025                2030        
His Val Val Phe Phe Val Ser Gly Lys Tyr Leu Arg Gln Lys Arg Ile
        2035                2040                2045            
Asp Phe Gln Leu Pro Tyr Asp Ile Leu Trp Gln Trp Lys His Asn Gln
    2050                2055                2060                
Leu Tyr Lys Lys Pro Asp Val Pro Leu Tyr Lys Lys Ile Arg Ser Asn
2065                2070                2075                2080
Val Tyr Val Asp Val Lys Pro Leu Ser Gly Tyr Glu Ala Thr Thr Cys
                2085                2090                2095    
Asn Cys Lys Lys Pro Asp Asp Asp Thr Arg Lys Gly Cys Val Asp Asp
            2100                2105                2110        
Cys Leu Asn Arg Met Ile Phe Ala Glu Cys Ser Pro Asn Thr Cys Pro
        2115                2120                2125            
Cys Gly Glu Gln Cys Cys Asn Gln Arg Ile Gln Arg His Glu Trp Val
    2130                2135                2140                
Gln Cys Leu Glu Arg Phe Arg Ala Glu Glu Lys Gly Trp Gly Ile Arg
2145                2150                2155                2160
Thr Lys Glu Pro Leu Lys Ala Gly Gln Phe Ile Ile Glu Tyr Leu Gly
                2165                2170                2175    
Glu Val Val Ser Glu Gln Glu Phe Arg Asn Arg Met Ile Glu Gln Tyr
            2180                2185                2190        
His Asn His Ser Asp His Tyr Cys Leu Asn Leu Asp Ser Gly Met Val
        2195                2200                2205            
Ile Asp Ser Tyr Arg Met Gly Asn Glu Ala Arg Phe Ile Asn His Ser
    2210                2215                2220                
Cys Asp Pro Asn Cys Glu Met Gln Lys Trp Ser Val Asn Gly Val Tyr
2225                2230                2235                2240
Arg Ile Gly Leu Tyr Ala Leu Lys Asp Met Pro Ala Gly Thr Glu Leu
                2245                2250                2255    
Thr Tyr Asp Tyr Asn Phe His Ser Phe Asn Val Glu Lys Gln Gln Leu
            2260                2265                2270        
Cys Lys Cys Gly Phe Glu Lys Cys Arg Gly Ile Ile Gly Gly Lys Ser
        2275                2280                2285            
Gln Arg Val Asn Gly Leu Thr Ser Ser Lys Asn Ser Gln Pro Met Ala
    2290                2295                2300                
Thr His Lys Lys Ser Gly Arg Ser Lys Glu Lys Arg Lys Ser Lys His
2305                2310                2315                2320
Lys Leu Lys Lys Arg Arg Gly His Leu Ser Glu Glu Pro Ser Glu Asn
                2325                2330                2335    
Ile Asn Thr Pro Thr Arg Leu Thr Pro Gln Leu Gln Met Lys Pro Met
            2340                2345                2350        
Ser Asn Arg Glu Arg Asn Phe Val Leu Lys His His Val Phe Leu Val
        2355                2360                2365            
Arg Asn Trp Glu Lys Ile Arg Gln Lys Gln Glu Glu Val Lys His Thr
    2370                2375                2380                
Ser Asp Asn Ile His Ser Ala Ser Leu Tyr Thr Arg Trp Asn Gly Ile
2385                2390                2395                2400
Cys Arg Asp Asp Gly Asn Ile Lys Ser Asp Val Phe Met Thr Gln Phe
                2405                2410                2415    
Ser Ala Leu Gln Thr Ala Arg Ser Val Arg Thr Arg Arg Leu Ala Ala
            2420                2425                2430        
Ala Glu Glu Asn Ile Glu Val Ala Arg Ala Ala Arg Leu Ala Gln Ile
        2435                2440                2445            
Phe Lys Glu Ile Cys Asp Gly Ile Ile Ser Tyr Lys Asp Ser Ser Arg
    2450                2455                2460                
Gln Ala Leu Ala Ala Pro Leu Leu Asn Leu Pro Pro Lys Lys Lys Asn
2465                2470                2475                2480
Ala Asp Tyr Tyr Glu Lys Ile Ser Asp Pro Leu Asp Leu Ile Thr Ile
                2485                2490                2495    
Glu Lys Gln Ile Leu Thr Gly Tyr Tyr Lys Thr Val Glu Ala Phe Asp
            2500                2505                2510        
Ala Asp Met Leu Lys Val Phe Arg Asn Ala Glu Lys Tyr Tyr Gly Arg
        2515                2520                2525            
Lys Ser Pro Val Gly Arg Asp Val Cys Arg Leu Arg Lys Ala Tyr Tyr
    2530                2535                2540                
Asn Ala Arg His Glu Ala Ser Ala Gln Ile Asp Glu Ile Val Gly Glu
2545                2550                2555                2560
Thr Ala Ser Glu Ala Asp Ser Ser Glu Thr Ser Val Ser Glu Lys Glu
                2565                2570                2575    
Asn Gly His Glu Lys Asp Asp Asp Val Ile Arg Cys Ile Cys Gly Leu
            2580                2585                2590        
Tyr Asn Asp Glu Gly Leu Met Ile Gln Cys Asp Lys Cys Met Val Trp
        2595                2600                2605            
Gln His Cys Asp Cys Met Gly Val Asn Ser Asp Val Glu His Tyr Leu
    2610                2615                2620                
Cys Glu Gln Cys Asp Pro Arg Pro Val Asp Arg Glu Val Pro Met Ile
2625                2630                2635                2640
Pro Arg Pro His Tyr Ala Gln Pro Gly Cys Val Tyr Phe Ile Cys Leu
                2645                2650                2655    
Leu Arg Asp Asp Leu Leu Leu Arg Gln Gly Asp Cys Val Tyr Leu Met
            2660                2665                2670        
Arg Asp Ser Arg Arg Thr Pro Asp Gly His Pro Val Arg Gln Ser Tyr
        2675                2680                2685            
Arg Leu Leu Ser His Ile Asn Arg His Lys Leu Asp Ile Phe Arg Ile
    2690                2695                2700                
Glu Lys Leu Trp Lys Asn Glu Lys Glu Glu Arg Phe Ala Phe Gly His
2705                2710                2715                2720
His Tyr Phe Arg Pro His Glu Thr His His Ser Pro Ser Arg Arg Phe
                2725                2730                2735    
Tyr His Asn Glu Leu Phe Arg Val Pro Leu Tyr Glu Ile Ile Pro Leu
            2740                2745                2750        
Glu Ala Val Val Gly Thr Cys Cys Val Leu Asp Leu Tyr Thr Tyr Cys
        2755                2760                2765            
Lys Gly Arg Pro Lys Gly Val Lys Glu Gln Asp Val Tyr Ile Cys Asp
    2770                2775                2780                
Tyr Arg Leu Asp Lys Ser Ala His Leu Phe Tyr Lys Ile His Arg Asn
2785                2790                2795                2800
Arg Tyr Pro Val Cys Thr Lys Pro Tyr Ala Phe Asp His Phe Pro Lys
                2805                2810                2815    
Lys Leu Thr Pro Lys Lys Asp Phe Ser Pro His Tyr Val Pro Asp Asn
            2820                2825                2830        
Tyr Lys Arg Asn Gly Gly Arg Ser Ser Trp Lys Ser Glu Arg Ser Lys
        2835                2840                2845            
Pro Pro Leu Lys Asp Leu Gly Gln Glu Asp Asp Ala Leu Pro Leu Ile
    2850                2855                2860                
Glu Glu Val Leu Ala Ser Gln Glu Gln Ala Ala Asn Glu Ile Pro Ser
2865                2870                2875                2880
Leu Glu Glu Pro Glu Arg Glu Gly Ala Thr Ala Asn Val Ser Glu Gly
                2885                2890                2895    
Glu Lys Lys Thr Glu Glu Ser Ser Gln Glu Pro Gln Ser Thr Cys Thr
            2900                2905                2910        
Pro Glu Glu Arg Arg His Asn Gln Arg Glu Arg Leu Asn Gln Ile Leu
        2915                2920                2925            
Leu Asn Leu Leu Glu Lys Ile Pro Gly Lys Asn Ala Ile Asp Val Thr
    2930                2935                2940                
Tyr Leu Leu Glu Glu Gly Ser Gly Arg Lys Leu Arg Arg Arg Thr Leu
2945                2950                2955                2960
Phe Ile Pro Glu Asn Ser Phe Arg Lys
                2965                


<210> 7364
<211> 1630
<212> PRT
<213> Homo sapiens

<400> 7364
Met Pro Phe Ala Lys Arg Ile Val Glu Pro Gln Trp Leu Cys Arg Gln
 1               5                  10                  15      
Arg Arg Pro Ala Pro Gly Pro Ala Val Asp Ala Ser Gly Gly Ser Ala
            20                  25                  30          
Glu Pro Pro Pro Pro Leu Gln Pro Pro Gly Arg Arg Asp Leu Asp Glu
        35                  40                  45              
Val Glu Ala Pro Gly Pro Glu Glu Pro Ala Arg Ala Val Pro Ala Pro
    50                  55                  60                  
Ser Gly Leu Pro Pro Pro Pro Pro Pro Leu Pro Ala Pro Ala Asp Gln
65                  70                  75                  80  
Thr Gln Pro Pro His Gly Glu Ala Ser Val Ala Gly Glu Glu Ser Thr
                85                  90                  95      
Ala Gly Ile Pro Glu Ala Ala Pro Ala Ala Gly Glu Ala Ser Ser Ala
            100                 105                 110         
Ala Ala Ala Ala Ala Val Leu Leu Met Leu Asp Leu Cys Ala Val Ser
        115                 120                 125             
Asn Ala Ala Leu Ala Arg Val Leu Arg Gln Leu Ser Asp Val Ala Arg
    130                 135                 140                 
His Ala Cys Ser Leu Phe Gln Glu Leu Glu Ser Asp Ile Gln Leu Thr
145                 150                 155                 160 
His Arg Arg Val Trp Ala Leu Gln Gly Lys Leu Gly Gly Val Gln Arg
                165                 170                 175     
Val Leu Ser Thr Leu Asp Pro Lys Gln Glu Ala Val Pro Val Ser Asn
            180                 185                 190         
Leu Asp Ile Glu Ser Lys Leu Ser Val Tyr Tyr Arg Ala Pro Trp His
        195                 200                 205             
Gln Gln Arg Asn Ile Phe Leu Pro Ala Thr Arg Pro Pro Cys Val Glu
    210                 215                 220                 
Glu Leu His Arg His Ala Arg Gln Ser Leu Gln Ala Leu Arg Arg Glu
225                 230                 235                 240 
His Arg Ser Arg Ser Asp Arg Arg Glu Gln Arg Ala Ala Ala Pro Leu
                245                 250                 255     
Ser Ile Ala Ala Pro Pro Leu Pro Ala Tyr Pro Pro Ala His Ser Gln
            260                 265                 270         
Arg Arg Arg Glu Phe Lys Asp Arg His Phe Leu Thr Ser His Pro Pro
        275                 280                 285             
Glu Asp Glu Asp Thr Asp Val Met Leu Gly Gln Arg Pro Lys Asn Pro
    290                 295                 300                 
Ile His Asn Ile Pro Ser Thr Leu Asp Lys Gln Thr Asn Trp Ser Lys
305                 310                 315                 320 
Ala Leu Pro Leu Pro Thr Pro Glu Glu Lys Met Lys Gln Asp Ala Gln
                325                 330                 335     
Val Ile Ser Ser Cys Ile Ile Pro Ile Asn Val Thr Gly Val Gly Phe
            340                 345                 350         
Asp Arg Glu Ala Ser Ile Arg Cys Ser Leu Val His Ser Gln Ser Val
        355                 360                 365             
Leu Gln Arg Arg Arg Lys Leu Arg Arg Arg Lys Thr Ile Ser Gly Ile
    370                 375                 380                 
Pro Arg Arg Val Gln Gln Glu Ile Asp Ser Asp Glu Ser Pro Val Ala
385                 390                 395                 400 
Arg Glu Arg Asn Val Ile Val His Thr Asn Pro Asp Pro Ser Asn Thr
                405                 410                 415     
Val Asn Arg Ile Ser Gly Thr Arg Asp Ser Glu Cys Gln Thr Glu Asp
            420                 425                 430         
Ile Leu Ile Ala Ala Pro Ser Arg Arg Arg Ile Arg Ala Gln Arg Gly
        435                 440                 445             
Gln Ser Ile Ala Ala Ser Leu Ser His Ser Ala Gly Asn Ile Ser Ala
    450                 455                 460                 
Leu Ala Asp Lys Gly Asp Thr Met Phe Thr Pro Ala Val Ser Ser Arg
465                 470                 475                 480 
Thr Arg Ser Arg Ser Leu Pro Arg Glu Gly Asn Arg Gly Gly Asp Ala
                485                 490                 495     
Glu Pro Lys Val Gly Ala Lys Pro Ser Ala Tyr Glu Glu Gly Glu Ser
            500                 505                 510         
Phe Val Gly Asp His Glu Arg Thr Pro Asn Asp Phe Ser Glu Ala Pro
        515                 520                 525             
Ser Ser Pro Ser Ala Gln Asp His Gln Pro Thr Leu Gly Leu Ala Cys
    530                 535                 540                 
Ser Gln His Leu His Ser Pro Gln His Lys Leu Ser Glu Arg Gly Arg
545                 550                 555                 560 
Ser Arg Leu Ser Arg Met Ala Ala Asp Ser Gly Ser Cys Asp Ile Ser
                565                 570                 575     
Ser Asn Ser Asp Thr Phe Gly Ser Pro Ile His Cys Ile Ser Thr Ala
            580                 585                 590         
Gly Val Leu Leu Ser Ser His Met Asp Gln Lys Asp Asp His Gln Ser
        595                 600                 605             
Ser Ser Gly Asn Trp Ser Gly Ser Ser Ser Thr Cys Pro Ser Gln Thr
    610                 615                 620                 
Ser Glu Thr Ile Pro Pro Ala Ala Ser Pro Pro Leu Thr Gly Ser Ser
625                 630                 635                 640 
His Cys Asp Ser Glu Leu Ser Leu Asn Thr Ala Pro His Ala Asn Glu
                645                 650                 655     
Asp Ala Ser Val Phe Val Thr Glu Gln Tyr Asn Asp His Leu Asp Lys
            660                 665                 670         
Val Arg Gly His Arg Ala Asn Ser Phe Thr Ser Thr Val Ala Asp Leu
        675                 680                 685             
Leu Asp Asp Pro Asn Asn Ser Asn Thr Ser Asp Ser Glu Trp Asn Tyr
    690                 695                 700                 
Leu His His His His Asp Ala Ser Cys Arg Gln Asp Phe Ser Pro Glu
705                 710                 715                 720 
Arg Pro Lys Ala Asp Ser Leu Gly Cys Pro Ser Phe Thr Ser Met Ala
                725                 730                 735     
Thr Tyr Asp Ser Phe Leu Glu Lys Ser Pro Ser Asp Lys Ala Asp Thr
            740                 745                 750         
Ser Ser His Phe Ser Val Asp Thr Glu Gly Tyr Tyr Thr Ser Met His
        755                 760                 765             
Phe Asp Cys Gly Leu Lys Gly Asn Lys Ser Tyr Val Cys His Tyr Ala
    770                 775                 780                 
Ala Leu Gly Pro Glu Asn Gly Gln Gly Val Gly Ala Ser Pro Gly Leu
785                 790                 795                 800 
Pro Asp Cys Ala Trp Gln Asp Tyr Leu Asp His Lys Arg Gln Gly Arg
                805                 810                 815     
Pro Ser Ile Ser Phe Arg Lys Pro Lys Ala Lys Pro Thr Pro Pro Lys
            820                 825                 830         
Arg Ser Ser Ser Leu Arg Lys Ser Asp Gly Asn Ala Asp Ile Ser Glu
        835                 840                 845             
Lys Lys Glu Pro Lys Ile Ser Ser Gly Gln His Leu Pro His Ser Ser
    850                 855                 860                 
Arg Glu Met Lys Leu Pro Leu Asp Phe Ala Asn Thr Pro Ser Arg Met
865                 870                 875                 880 
Glu Asn Ala Asn Leu Pro Thr Lys Gln Glu Pro Ser Trp Ile Asn Gln
                885                 890                 895     
Ser Glu Gln Gly Ile Lys Glu Pro Gln Leu Asp Ala Ser Asp Ile Pro
            900                 905                 910         
Pro Phe Lys Asp Glu Val Ala Glu Ser Thr His Tyr Ala Asp Leu Trp
        915                 920                 925             
Leu Leu Asn Asp Leu Lys Thr Asn Asp Pro Tyr Arg Ser Leu Ser Asn
    930                 935                 940                 
Ser Ser Thr Ala Thr Gly Thr Thr Val Ile Glu Cys Ile Lys Ser Pro
945                 950                 955                 960 
Glu Ser Ser Glu Ser Gln Thr Ser Gln Ser Glu Ser Arg Ala Thr Thr
                965                 970                 975     
Pro Ser Leu Pro Ser Val Asp Asn Glu Phe Lys Leu Ala Ser Pro Glu
            980                 985                 990         
Lys Leu Ala Gly Leu Ala Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser
        995                 1000                1005            
Glu Thr Pro Thr Ser Ser Phe Pro Thr Ala Phe Phe Ser Gly Pro Leu
    1010                1015                1020                
Ser Pro Gly Gly Ser Lys Arg Lys Pro Lys Val Pro Glu Arg Lys Ser
1025                1030                1035                1040
Ser Leu Gln Gln Pro Ser Leu Lys Asp Gly Thr Ile Ser Leu Ser Lys
                1045                1050                1055    
Asp Leu Glu Leu Pro Ile Ile Pro Pro Thr His Leu Asp Leu Ser Ala
            1060                1065                1070        
Leu His Asn Val Leu Asn Lys Pro Phe His His Arg His Pro Leu His
        1075                1080                1085            
Val Phe Thr His Asn Lys Gln Asn Thr Val Gly Glu Thr Leu Arg Ser
    1090                1095                1100                
Asn Pro Pro Pro Ser Leu Ala Ile Thr Pro Thr Ile Leu Lys Ser Val
1105                1110                1115                1120
Asn Leu Arg Ser Ile Asn Lys Ser Glu Glu Val Lys Gln Lys Glu Glu
                1125                1130                1135    
Asn Asn Thr Asp Leu Pro Tyr Leu Glu Glu Ser Thr Leu Thr Thr Ala
            1140                1145                1150        
Ala Leu Ser Pro Ser Lys Ile Arg Pro His Thr Ala Asn Lys Ser Val
        1155                1160                1165            
Ser Arg Gln Tyr Ser Thr Glu Asp Thr Ile Leu Ser Phe Leu Asp Ser
    1170                1175                1180                
Ser Ala Val Glu Met Gly Pro Asp Lys Leu His Leu Glu Lys Asn Ser
1185                1190                1195                1200
Thr Phe Asp Val Lys Asn Arg Cys Asp Pro Glu Thr Ile Thr Ser Ala
                1205                1210                1215    
Gly Ser Ser Leu Leu Asp Ser Asn Val Thr Lys Asp Gln Val Arg Thr
            1220                1225                1230        
Glu Thr Glu Pro Ile Pro Glu Asn Thr Pro Thr Lys Asn Cys Ala Phe
        1235                1240                1245            
Pro Thr Glu Gly Phe Gln Arg Val Ser Ala Ala Arg Pro Asn Asp Leu
    1250                1255                1260                
Asp Gly Lys Ile Ile Gln Tyr Gly Pro Gly Pro Asp Glu Thr Leu Glu
1265                1270                1275                1280
Gln Val Gln Lys Ala Pro Ser Ala Gly Leu Glu Glu Val Ala Gln Pro
                1285                1290                1295    
Glu Ser Val Asp Val Ile Thr Ser Gln Ser Asp Ser Pro Thr Arg Ala
            1300                1305                1310        
Thr Asp Val Ser Asn Gln Phe Lys His Gln Phe Val Met Ser Arg His
        1315                1320                1325            
His Asp Lys Val Pro Gly Thr Ile Ser Tyr Glu Ser Glu Ile Thr Ser
    1330                1335                1340                
Val Asn Ser Phe Pro Glu Lys Cys Ser Lys Gln Glu Asn Ile Ala Ser
1345                1350                1355                1360
Gly Ile Ser Ala Lys Ser Ala Ser Asp Asn Ser Lys Ala Glu Glu Thr
                1365                1370                1375    
Gln Gly Asn Val Asp Glu Ala Ser Leu Lys Glu Ser Ser Pro Ser Asp
            1380                1385                1390        
Asp Ser Ile Ile Ser Pro Leu Ser Glu Asp Ser Gln Ala Glu Ala Glu
        1395                1400                1405            
Gly Val Phe Val Ser Pro Asn Lys Pro Arg Thr Thr Glu Asp Leu Phe
    1410                1415                1420                
Ala Val Ile His Arg Ser Lys Arg Lys Val Leu Gly Arg Lys Asp Ser
1425                1430                1435                1440
Gly Asp Met Ser Val Arg Ser Lys Ser Arg Ala Pro Leu Ser Ser Ser
                1445                1450                1455    
Ser Ser Ser Ala Ser Ser Ile Thr Ser Pro Ser Ser Asn Val Thr Thr
            1460                1465                1470        
Pro Asn Ser Gln Arg Ser Pro Gly Leu Ile Tyr Arg Asn Ala Lys Lys
        1475                1480                1485            
Ser Asn Thr Ser Asn Glu Glu Phe Lys Leu Leu Leu Leu Lys Lys Gly
    1490                1495                1500                
Ser Arg Ser Asp Ser Ser Tyr Arg Met Ser Ala Thr Glu Ile Leu Lys
1505                1510                1515                1520
Ser Pro Ile Leu Pro Lys Pro Pro Gly Glu Leu Thr Ala Glu Ser Pro
                1525                1530                1535    
Gln Ser Thr Asp Asp Ala His Gln Gly Ser Gln Gly Ala Glu Ala Leu
            1540                1545                1550        
Ser Pro Leu Ser Pro Cys Ser Pro Arg Val Asn Ala Glu Gly Phe Ser
        1555                1560                1565            
Ser Lys Ser Phe Ala Thr Ser Ala Ser Ala Arg Val Gly Arg Ser Arg
    1570                1575                1580                
Ala Pro Pro Ala Ala Ser Ser Ser Arg Tyr Ser Val Arg Cys Arg Leu
1585                1590                1595                1600
Tyr Asn Thr Pro Met Gln Ala Ile Ser Glu Gly Glu Thr Glu Asn Ser
                1605                1610                1615    
Asp Gly Ser Pro His Asp Asp Arg Ser Ser Gln Ser Ser Thr
            1620                1625                1630


<210> 7365
<211> 3036
<212> PRT
<213> Homo sapiens

<400> 7365
Met His Leu His Gln Val Leu Thr Gly Ala Val Asn Pro Gly Asp Asn
 1               5                  10                  15      
Cys Tyr Ser Val Gly Ser Val Gly Asp Val Pro Phe Thr Ala Tyr Gly
            20                  25                  30          
Ser Gly Cys Asp Ile Val Ile Leu Ala Asn Asp Phe Glu Cys Val Gln
        35                  40                  45              
Ile Ile Pro Gly Ala Lys His Gly Asn Ile Gln Val Ser Cys Val Glu
    50                  55                  60                  
Cys Ser Asn Gln Gln Gly Arg Ile Ala Ala Ser Tyr Gly Asn Ala Val
65                  70                  75                  80  
Cys Ile Phe Glu Pro Leu Gly Ile Asn Ser His Lys Arg Asn Cys Gln
                85                  90                  95      
Leu Lys Cys Gln Trp Leu Lys Thr Gly Gln Phe Phe Leu Ser Ser Val
            100                 105                 110         
Thr Tyr Asn Leu Ala Trp Asp Pro Gln Asp Asn Arg Leu Leu Thr Thr
        115                 120                 125             
Thr Asp Ser Ile Gln Leu Trp Ala Pro Pro Gly Asp Asp Ile Leu Glu
    130                 135                 140                 
Glu Glu Glu Glu Ile Asp Asn Thr Val Pro Pro Val Leu Asn Asp Trp
145                 150                 155                 160 
Lys Cys Val Trp Gln Cys Lys Thr Ser Val Ser Val His Leu Met Glu
                165                 170                 175     
Trp Ser Pro Asp Gly Glu Tyr Phe Ala Thr Ala Gly Lys Asp Asp Cys
            180                 185                 190         
Leu Leu Lys Val Trp Tyr Pro Met Thr Gly Trp Lys Ser Ser Ile Ile
        195                 200                 205             
Pro Gln Asp His His Glu Val Lys Arg Arg Gln Ser Ser Thr Gln Phe
    210                 215                 220                 
Ser Phe Val Tyr Leu Ala His Pro Arg Ala Val Thr Gly Phe Ser Trp
225                 230                 235                 240 
Arg Lys Thr Ser Lys Tyr Met Pro Arg Gly Ser Val Cys Asn Val Leu
                245                 250                 255     
Leu Thr Ser Cys His Asp Gly Val Cys Arg Leu Trp Ala Glu Thr Leu
            260                 265                 270         
Leu Pro Glu Asp Cys Leu Leu Gly Glu Gln Ile Cys Glu Thr Thr Thr
        275                 280                 285             
Ser Ser Ile Ala Ser Ser Leu Ser His Ala Gly Arg His Lys Asp Arg
    290                 295                 300                 
Ile Gln His Ala Leu Glu Thr Ile His His Leu Lys Asn Leu Arg Lys
305                 310                 315                 320 
Gly Gln Arg Arg Ser Ser Val Leu Val Thr His Ala Glu Leu Met Pro
                325                 330                 335     
Asp Gln Thr Ala Met His Glu Val Gln Arg His Ile Ser His His Ala
            340                 345                 350         
Asn Ala Leu Cys His Phe His Ile Ala Ala Ser Ile Asn Pro Ala Thr
        355                 360                 365             
Asp Ile Pro Asn Val Leu Val Gly Thr Ala Phe Asn Val Asp Asp Gly
    370                 375                 380                 
Asn Gly Gly Phe Val Val His Trp Leu Asn Asn Lys Glu Phe His Phe
385                 390                 395                 400 
Thr Ser Ser Thr Glu Val Phe Met His Gln Leu Arg Lys Leu Ser Asp
                405                 410                 415     
Lys Gln Val Asp His Glu Asn Asp Asp Ala Asp Arg Glu Asp Glu Glu
            420                 425                 430         
His Ser Gln Glu Asp Arg Glu Arg Gly Leu His Met Lys Leu Asp His
        435                 440                 445             
Asp Leu Ser Leu Asp Arg Glu Ser Glu Ala Gly Thr Gly Ser Ser Glu
    450                 455                 460                 
His Glu Asp Gly Glu Arg Glu Gly Ser Pro Arg Thr Tyr Ser Arg Leu
465                 470                 475                 480 
Ser Val Pro Met Pro Leu Pro Thr Val Leu Leu Asp Arg Lys Ile Glu
                485                 490                 495     
Thr Leu Leu Thr Glu Trp Asn Lys Asn Pro Asp Met Leu Phe Thr Ile
            500                 505                 510         
His Pro Val Asp Gly Thr Phe Leu Val Trp His Val Lys Tyr Leu Asp
        515                 520                 525             
Glu Tyr Asn Pro Gly Ile Phe Arg Gln Val Gln Val Ser Phe Ser Ser
    530                 535                 540                 
Arg Ile Pro Val Ala Phe Pro Ser Gly Asp Ala Ser Ser Leu Ser Lys
545                 550                 555                 560 
Asn Ile Met Met Tyr Ala Cys Ile Asn Ala Thr Lys Asp Ser His His
                565                 570                 575     
Thr Leu Leu His Gln Glu Gly Met Ser Val Gly Ser Pro His Gly Ser
            580                 585                 590         
Gln Pro His Ser Arg Ser His Ser Thr His Met Asn Ile Leu Ala Pro
        595                 600                 605             
Thr Val Met Met Ile Ser Lys His Ile Asp Gly Ser Leu Asn Gln Trp
    610                 615                 620                 
Ala Val Thr Phe Ala Asp Lys Ser Ala Phe Thr Thr Val Leu Thr Val
625                 630                 635                 640 
Ser His Lys Phe Arg Tyr Cys Gly His Arg Phe His Leu Asn Asp Leu
                645                 650                 655     
Ala Cys His Ser Val Leu Pro Leu Leu Leu Thr Ser Ser His His Asn
            660                 665                 670         
Ala Leu Leu Thr Pro Glu Leu Asp Cys Gln Trp Asp Ser Asp Asn Lys
        675                 680                 685             
Leu Ser Arg Leu Met Asp Pro Val Lys His Ile Lys Gly Ser Ser Lys
    690                 695                 700                 
Gln Pro Leu Arg Asn Ala Ala Thr Arg Thr Phe His Asp Pro Asn Ala
705                 710                 715                 720 
Ile Tyr Ser Glu Leu Ile Leu Trp Arg Val Asp Pro Ile Gly Pro Leu
                725                 730                 735     
Ser Tyr Thr Gly Gly Val Ser Glu Leu Ala Arg Ile Asn Ser Leu His
            740                 745                 750         
Thr Ser Ala Phe Ser Asn Val Ala Trp Leu Pro Thr Leu Ile Pro Ser
        755                 760                 765             
Tyr Cys Leu Gly Thr Tyr Cys Asn Ser Ala Ser Ala Cys Phe Val Ala
    770                 775                 780                 
Ser Asp Gly Lys Asn Leu Arg Leu Tyr Gln Ala Val Val Asp Ala Arg
785                 790                 795                 800 
Lys Leu Leu Asp Glu Leu Ser Asp Pro Glu Ser Ser Lys Leu Ile Gly
                805                 810                 815     
Glu Val Phe Asn Ile Val Ser Gln Gln Ser Thr Ala Arg Pro Gly Cys
            820                 825                 830         
Ile Ile Glu Leu Asp Ala Ile Thr Asn Gln Cys Gly Ser Asn Thr Gln
        835                 840                 845             
Leu Leu His Val Phe Gln Glu Asp Phe Ile Ile Gly Tyr Lys Pro His
    850                 855                 860                 
Lys Glu Asp Met Glu Lys Lys Glu Thr Glu Ile Phe Phe Gln Pro Ser
865                 870                 875                 880 
Gln Gly Tyr Arg Pro Pro Pro Phe Ser Glu Lys Phe Phe Leu Val Val
                885                 890                 895     
Ile Glu Lys Asp Ser Asn Asn Asn Ser Ile Leu His Met Trp His Leu
            900                 905                 910         
His Leu Lys Ser Val Gln Ala Cys Leu Ala Lys Ala Ser Glu Gly Ala
        915                 920                 925             
Ser Ser Glu Ser Leu Leu Ser Val Pro Gly Gln Lys Asn Val Asp Ser
    930                 935                 940                 
Ser Pro Glu Thr Ser Pro Ser Val Ser Pro Met Pro His Ser Ser Ser
945                 950                 955                 960 
Ile Ala Asn Leu Gln Thr Ala Ser Lys Leu Ile Leu Ser Phe Arg Leu
                965                 970                 975     
Val Tyr Ser Gln Pro Leu Asp Leu Pro Glu Ser Val Glu Val Ile Arg
            980                 985                 990         
Ala Thr Pro Ser Ala Gly His Leu Ser Ser Ser Ser Ile Tyr Pro Val
        995                 1000                1005            
Cys Leu Ala Pro Tyr Leu Val Val Thr Thr Cys Ser Asp Asn Lys Val
    1010                1015                1020                
Arg Phe Trp Lys Cys Cys Met Glu Ala Asn Pro Glu Cys Asn Lys Ser
1025                1030                1035                1040
Asp Glu Lys Glu Ile Tyr His Trp Lys Arg Trp Pro Leu Met Asn Asp
                1045                1050                1055    
Glu Gly Glu Asp Asn Ser Ser Thr Val Ser Ile Val Gly Arg Pro Val
            1060                1065                1070        
Ala Val Ser Cys Ser Tyr Thr Gly Arg Leu Ala Val Ala Tyr Lys Gln
        1075                1080                1085            
Pro Ile His His Asn Gly Phe Val Ser Lys Glu Phe Ser Met His Val
    1090                1095                1100                
Cys Ile Phe Glu Cys Glu Ser Thr Gly Gly Ser Glu Trp Val Leu Glu
1105                1110                1115                1120
Gln Thr Ile His Leu Asp Asp Leu Val Lys Val Gly Ser Val Leu Asp
                1125                1130                1135    
Ser Arg Val Ser Val Asp Ser Asn Leu Phe Val Tyr Ser Lys Ser Asp
            1140                1145                1150        
Ala Leu Leu Ser Lys Asp Arg Tyr Leu Ile Pro Asn Ile Lys His Leu
        1155                1160                1165            
Val His Leu Asp Trp Val Ser Lys Glu Asp Gly Ser His Ile Leu Thr
    1170                1175                1180                
Val Gly Val Gly Ala Asn Ile Phe Met Tyr Gly Arg Leu Ser Gly Ile
1185                1190                1195                1200
Val Thr Glu Gln Thr Asn Ser Lys Asp Gly Val Ala Val Ile Thr Leu
                1205                1210                1215    
Pro Leu Gly Gly Ser Ile Lys Gln Gly Val Lys Ser Arg Trp Val Leu
            1220                1225                1230        
Leu Arg Ser Ile Asp Leu Val Ser Ser Val Asp Gly Thr Pro Ser Leu
        1235                1240                1245            
Pro Val Ser Leu Ser Trp Val Arg Asp Gly Ile Leu Val Val Gly Met
    1250                1255                1260                
Asp Cys Glu Met His Val Tyr Ala Gln Trp Lys His Ala Val Lys Phe
1265                1270                1275                1280
Gly Asp Thr Glu Ala Asp Ser Ser Asn Ala Glu Glu Ala Ala Met Gln
                1285                1290                1295    
Asp His Ser Thr Phe Lys Ser Asn Met Leu Ala Arg Lys Ser Val Val
            1300                1305                1310        
Glu Gly Thr Ala Ile Ser Asp Asp Val Phe Cys Ser Pro Thr Val Ile
        1315                1320                1325            
Gln Asp Gly Gly Leu Phe Glu Ala Ala His Val Leu Ser Pro Thr Leu
    1330                1335                1340                
Pro Gln Tyr His Pro Thr Gln Leu Leu Glu Leu Met Asp Leu Gly Lys
1345                1350                1355                1360
Val Arg Arg Ala Lys Ala Ile Leu Ser His Leu Val Lys Cys Ile Ala
                1365                1370                1375    
Gly Glu Val Ala Ile Val Arg Asp Pro Asp Ala Gly Glu Gly Thr Lys
            1380                1385                1390        
Arg His Leu Ser Arg Thr Ile Ser Val Ser Gly Ser Thr Ala Lys Glu
        1395                1400                1405            
Thr Val Thr Val Gly Lys Asp Gly Thr Arg Asp Tyr Thr Glu Ile Asp
    1410                1415                1420                
Ser Ile Pro Pro Leu Pro Leu Tyr Ala Leu Leu Ala Ala Asp Gln Asp
1425                1430                1435                1440
Thr Ser Tyr Arg Ile Ser Glu Glu Ser Thr Lys Ile Pro Gln Ser Tyr
                1445                1450                1455    
Glu Asp Gln Thr Val Ser Gln Pro Glu Asp Gln Tyr Ser Glu Leu Phe
            1460                1465                1470        
Gln Ile Gln Asp Ile Pro Thr Asp Asp Ile Asp Leu Glu Pro Glu Lys
        1475                1480                1485            
Arg Glu Asn Lys Ser Lys Val Ile Asn Leu Ser Gln Tyr Gly Pro Ala
    1490                1495                1500                
Tyr Phe Gly Gln Glu His Ala Arg Val Leu Ser Ser His Leu Met His
1505                1510                1515                1520
Ser Ser Leu Pro Gly Leu Thr Arg Leu Glu Gln Met Phe Leu Val Ala
                1525                1530                1535    
Leu Ala Asp Thr Val Ala Thr Thr Ser Thr Glu Leu Asp Glu Ser Arg
            1540                1545                1550        
Asp Lys Ser Cys Ser Gly Arg Asp Thr Leu Asp Glu Cys Gly Leu Arg
        1555                1560                1565            
Tyr Leu Leu Ala Met Arg Leu His Thr Cys Leu Leu Thr Ser Leu Pro
    1570                1575                1580                
Pro Leu Tyr Arg Val Gln Leu Leu His Gln Gly Val Ser Thr Cys His
1585                1590                1595                1600
Phe Ala Trp Ala Phe His Ser Glu Ala Glu Glu Glu Leu Ile Asn Met
                1605                1610                1615    
Ile Pro Ala Ile Gln Arg Gly Asp Pro Gln Trp Ser Glu Leu Arg Ala
            1620                1625                1630        
Met Gly Ile Gly Trp Trp Val Arg Asn Ile Asn Thr Leu Arg Arg Cys
        1635                1640                1645            
Ile Glu Lys Val Ala Lys Ala Ser Phe Gln Arg Asn Asn Asp Ala Leu
    1650                1655                1660                
Asp Ala Ala Leu Phe Tyr Leu Ser Met Lys Lys Lys Ala Val Val Trp
1665                1670                1675                1680
Gly Leu Phe Arg Ser Gln His Asp Glu Lys Met Thr Thr Phe Phe Ser
                1685                1690                1695    
His Asn Phe Asn Glu Asp Arg Trp Arg Lys Ala Ala Leu Lys Asn Ala
            1700                1705                1710        
Phe Ser Leu Leu Gly Lys Gln Arg Phe Glu Gln Ser Ala Ala Phe Phe
        1715                1720                1725            
Leu Leu Ala Gly Ser Leu Lys Asp Ala Ile Glu Val Cys Leu Glu Lys
    1730                1735                1740                
Met Glu Asp Ile Gln Leu Ala Met Val Ile Ala Arg Leu Tyr Glu Ser
1745                1750                1755                1760
Glu Phe Glu Thr Ser Ser Thr Tyr Ile Ser Ile Leu Asn Gln Lys Ile
                1765                1770                1775    
Leu Gly Cys Gln Lys Asp Gly Ser Gly Phe Ser Cys Lys Arg Leu His
            1780                1785                1790        
Pro Asp Pro Phe Leu Arg Ser Leu Ala Tyr Trp Val Met Lys Asp Tyr
        1795                1800                1805            
Thr Arg Ala Leu Asp Thr Leu Leu Glu Gln Thr Pro Lys Glu Asp Asp
    1810                1815                1820                
Glu His Gln Val Ile Ile Lys Ser Cys Asn Pro Val Ala Phe Ser Phe
1825                1830                1835                1840
Tyr Asn Tyr Leu Arg Thr His Pro Leu Leu Ile Arg Arg Asn Leu Ala
                1845                1850                1855    
Ser Pro Glu Gly Thr Leu Ala Thr Leu Gly Leu Lys Thr Glu Lys Asn
            1860                1865                1870        
Phe Val Asp Lys Ile Asn Leu Ile Glu Arg Lys Leu Phe Phe Thr Thr
        1875                1880                1885            
Ala Asn Ala His Phe Lys Val Gly Cys Pro Val Leu Ala Leu Glu Val
    1890                1895                1900                
Leu Ser Lys Ile Pro Lys Val Thr Lys Thr Ser Ala Leu Ser Ala Lys
1905                1910                1915                1920
Lys Asp Gln Pro Asp Phe Ile Ser His Arg Met Asp Asp Val Pro Ser
                1925                1930                1935    
His Ser Lys Ala Leu Ser Asp Gly Asn Gly Ser Ser Gly Ile Glu Trp
            1940                1945                1950        
Ser Asn Val Thr Ser Ser Gln Tyr Asp Trp Ser Gln Pro Ile Val Lys
        1955                1960                1965            
Val Asp Glu Glu Pro Leu Asn Leu Asp Trp Gly Glu Asp His Asp Ser
    1970                1975                1980                
Ala Leu Asp Glu Glu Glu Asp Asp Ala Val Gly Leu Val Met Lys Ser
1985                1990                1995                2000
Thr Asp Ala Arg Glu Lys Asp Lys Gln Ser Asp Gln Lys Ala Ser Asp
                2005                2010                2015    
Pro Asn Met Leu Leu Thr Pro Gln Glu Glu Asp Asp Pro Glu Gly Asp
            2020                2025                2030        
Thr Glu Val Asp Val Ile Ala Glu Gln Leu Lys Phe Arg Ala Cys Leu
        2035                2040                2045            
Lys Ile Leu Met Thr Glu Leu Arg Thr Leu Ala Thr Gly Tyr Glu Val
    2050                2055                2060                
Asp Gly Gly Lys Leu Arg Phe Gln Leu Tyr Asn Trp Leu Glu Lys Glu
2065                2070                2075                2080
Ile Ala Ala Leu His Glu Ile Cys Asn His Glu Ser Val Ile Lys Glu
                2085                2090                2095    
Tyr Ser Ser Lys Thr Tyr Ser Lys Val Glu Ser Asp Leu Leu Asp Gln
            2100                2105                2110        
Glu Glu Met Val Asp Lys Pro Asp Ile Gly Ser Tyr Glu Arg His Gln
        2115                2120                2125            
Ile Glu Arg Arg Arg Leu Gln Ala Lys Arg Glu His Ala Glu Arg Arg
    2130                2135                2140                
Lys Ser Trp Leu Gln Lys Asn Gln Asp Leu Leu Arg Val Phe Leu Ser
2145                2150                2155                2160
Tyr Cys Ser Leu His Gly Ala Gln Gly Gly Gly Leu Ala Ser Val Arg
                2165                2170                2175    
Met Glu Leu Lys Phe Leu Leu Gln Glu Ser Gln Gln Glu Thr Thr Val
            2180                2185                2190        
Lys Gln Leu Gln Ser Pro Leu Pro Leu Pro Thr Thr Leu Pro Leu Leu
        2195                2200                2205            
Ser Ala Ser Ile Ala Ser Thr Lys Thr Val Ile Ala Asn Pro Val Leu
    2210                2215                2220                
Tyr Leu Asn Asn His Ile His Asp Ile Leu Tyr Thr Ile Val Gln Met
2225                2230                2235                2240
Lys Thr Pro Pro His Pro Ser Ile Glu Asp Val Lys Val His Thr Leu
                2245                2250                2255    
His Ser Leu Ala Ala Ser Leu Ser Ala Ser Ile Tyr Gln Ala Leu Cys
            2260                2265                2270        
Asp Ser His Ser Tyr Ser Gln Thr Glu Gly Asn Gln Phe Thr Gly Met
        2275                2280                2285            
Ala Tyr Gln Gly Leu Leu Leu Ser Asp Arg Arg Arg Leu Arg Thr Glu
    2290                2295                2300                
Ser Ile Glu Glu His Ala Thr Pro Asn Ser Ser Pro Ala Gln Trp Pro
2305                2310                2315                2320
Gly Val Ser Ser Leu Ile Asn Leu Leu Ser Ser Ala Gln Asp Glu Asp
                2325                2330                2335    
Gln Pro Lys Leu Asn Ile Leu Leu Cys Glu Ala Val Val Ala Val Tyr
            2340                2345                2350        
Leu Ser Leu Leu Ile His Ala Leu Ala Thr Asn Ser Ser Ser Glu Leu
        2355                2360                2365            
Phe Arg Leu Ala Ala His Pro Leu Asn Asn Arg Met Trp Ala Ala Val
    2370                2375                2380                
Phe Gly Gly Gly Val Lys Leu Val Val Lys Pro Arg Arg Gln Ser Glu
2385                2390                2395                2400
Asn Ile Ser Ala Pro Pro Val Leu Ser Glu Asp Ile Asp Lys His Arg
                2405                2410                2415    
Arg Arg Phe Asn Met Arg Met Leu Val Pro Gly Arg Pro Val Lys Asp
            2420                2425                2430        
Ala Thr Pro Pro Pro Val Pro Ala Glu Arg Pro Ser Tyr Lys Glu Lys
        2435                2440                2445            
Phe Ile Pro Pro Glu Leu Ser Met Trp Asp Tyr Phe Val Ala Lys Pro
    2450                2455                2460                
Phe Leu Pro Leu Ser Asp Ser Gly Val Ile Tyr Asp Ser Asp Glu Ser
2465                2470                2475                2480
Ile His Ser Asp Glu Glu Asp Asp Ala Phe Phe Ser Asp Thr Gln Ile
                2485                2490                2495    
Gln Glu His Gln Asp Pro Asn Ser Tyr Ser Trp Ala Leu Leu His Leu
            2500                2505                2510        
Thr Met Val Lys Leu Ala Leu His Asn Val Lys Asn Phe Phe Pro Ile
        2515                2520                2525            
Ala Gly Leu Glu Phe Ser Glu Leu Pro Val Thr Ser Pro Leu Gly Ile
    2530                2535                2540                
Ala Val Ile Lys Asn Leu Glu Asn Trp Glu Gln Ile Leu Gln Glu Lys
2545                2550                2555                2560
Met Asp Gln Phe Glu Gly Pro Pro Pro Asn Tyr Ile Asn Thr Tyr Pro
                2565                2570                2575    
Thr Asp Leu Ser Val Gly Ala Gly Pro Ala Ile Leu Arg Asn Lys Ala
            2580                2585                2590        
Met Leu Glu Pro Glu Asn Thr Pro Phe Lys Ser Arg Asp Ser Ser Ala
        2595                2600                2605            
Phe Pro Val Lys Arg Leu Trp His Phe Leu Val Lys Gln Glu Val Leu
    2610                2615                2620                
Gln Glu Thr Phe Ile Arg Tyr Ile Phe Thr Lys Lys Arg Lys Gln Ser
2625                2630                2635                2640
Glu Val Glu Ala Asp Leu Gly Tyr Pro Gly Gly Lys Ala Lys Val Ile
                2645                2650                2655    
His Lys Glu Ser Asp Met Ile Met Ala Phe Ser Val Asn Lys Ala Asn
            2660                2665                2670        
Cys Asn Glu Ile Val Leu Ala Ser Thr His Asp Val Gln Glu Leu Asp
        2675                2680                2685            
Val Thr Ser Leu Leu Ala Cys Gln Ser Tyr Ile Trp Ile Gly Glu Glu
    2690                2695                2700                
Tyr Asp Arg Glu Ser Lys Ser Ser Asp Asp Val Asp Tyr Arg Gly Ser
2705                2710                2715                2720
Thr Thr Thr Leu Tyr Gln Pro Ser Ala Thr Ser Tyr Ser Ala Ser Gln
                2725                2730                2735    
Val His Pro Pro Ser Ser Leu Pro Trp Leu Gly Thr Gly Gln Thr Ser
            2740                2745                2750        
Thr Gly Ala Ser Val Leu Met Lys Arg Asn Leu His Asn Val Lys Arg
        2755                2760                2765            
Met Thr Ser His Pro Val His Gln Tyr Tyr Leu Thr Gly Ala Gln Asp
    2770                2775                2780                
Gly Ser Val Arg Met Phe Glu Trp Thr Arg Pro Gln Gln Leu Val Cys
2785                2790                2795                2800
Phe Arg Gln Ala Gly Asn Ala Arg Val Thr Arg Leu Tyr Phe Asn Ser
                2805                2810                2815    
Gln Gly Asn Lys Cys Gly Val Ala Asp Gly Glu Gly Phe Leu Ser Ile
            2820                2825                2830        
Trp Gln Val Asn Gln Thr Ala Ser Asn Pro Lys Pro Tyr Met Ser Trp
        2835                2840                2845            
Gln Cys His Ser Lys Ala Thr Ser Asp Phe Ala Phe Ile Thr Ser Ser
    2850                2855                2860                
Ser Leu Val Ala Thr Ser Gly His Ser Asn Asp Asn Arg Asn Val Cys
2865                2870                2875                2880
Leu Trp Asp Thr Leu Ile Ser Pro Gly Asn Ser Leu Ile His Gly Phe
                2885                2890                2895    
Thr Cys His Asp His Gly Ala Thr Val Leu Gln Tyr Ala Pro Lys Gln
            2900                2905                2910        
Gln Leu Leu Ile Ser Gly Gly Arg Lys Gly His Val Cys Ile Phe Asp
        2915                2920                2925            
Ile Arg Gln Arg Gln Leu Ile His Thr Phe Gln Ala His Asp Ser Ala
    2930                2935                2940                
Ile Lys Ala Leu Ala Leu Asp Pro Tyr Glu Glu Tyr Phe Thr Thr Gly
2945                2950                2955                2960
Ser Ala Glu Gly Asn Ile Lys Val Trp Arg Leu Thr Gly His Gly Leu
                2965                2970                2975    
Ile His Ser Phe Lys Ser Glu Tyr Ala Lys Gln Ser Ile Phe Arg Asn
            2980                2985                2990        
Ile Gly Ala Gly Val Met Gln Ile Asp Ile Ile Gln Gly Asn Arg Leu
        2995                3000                3005            
Phe Ser Cys Gly Ala Asp Gly Thr Leu Lys Thr Arg Val Leu Pro Asn
    3010                3015                3020                
Ala Phe Asn Ile Pro Asn Arg Ile Leu Asp Ile Leu
3025                3030                3035    


<210> 7366
<211> 403
<212> PRT
<213> Homo sapiens

<400> 7366
Met Asp Ser Arg Glu Cys Leu Leu Phe Lys Asn Glu Cys Arg Lys Val
 1               5                  10                  15      
Tyr Gln Asp Met Thr His Pro Leu Asn Asp Tyr Phe Ile Ser Ser Ser
            20                  25                  30          
His Asn Thr Tyr Leu Val Ser Asp Gln Leu Leu Gly Pro Ser Asp Leu
        35                  40                  45              
Trp Gly Tyr Val Ser Ala Leu Val Lys Gly Cys Arg Cys Leu Glu Ile
    50                  55                  60                  
Asp Cys Trp Asp Gly Ala Gln Asn Glu Pro Val Val Tyr His Gly Tyr
65                  70                  75                  80  
Thr Leu Thr Ser Lys Leu Leu Phe Lys Thr Val Ile Gln Ala Ile His
                85                  90                  95      
Lys Tyr Ala Phe Met Thr Ser Asp Tyr Pro Val Val Leu Ser Leu Glu
            100                 105                 110         
Asn His Cys Ser Thr Ala Gln Gln Glu Val Met Ala Asp Asn Leu Gln
        115                 120                 125             
Ala Thr Phe Gly Glu Ser Leu Leu Ser Asp Met Leu Asp Asp Phe Pro
    130                 135                 140                 
Asp Thr Leu Pro Ser Pro Glu Ala Leu Lys Phe Lys Ile Leu Val Lys
145                 150                 155                 160 
Asn Lys Lys Ile Gly Thr Leu Lys Glu Thr His Glu Arg Lys Gly Ser
                165                 170                 175     
Asp Lys Arg Gly Asp Asn Gln Asp Lys Glu Thr Gly Val Lys Lys Leu
            180                 185                 190         
Pro Gly Val Met Leu Phe Lys Lys Lys Lys Thr Arg Lys Leu Lys Ile
        195                 200                 205             
Ala Leu Ala Leu Ser Asp Leu Val Ile Tyr Thr Lys Ala Glu Lys Phe
    210                 215                 220                 
Lys Ser Phe Gln His Ser Arg Leu Tyr Gln Gln Phe Asn Glu Asn Asn
225                 230                 235                 240 
Ser Ile Gly Glu Thr Gln Ala Arg Lys Leu Ser Lys Leu Arg Val His
                245                 250                 255     
Glu Phe Ile Phe His Thr Arg Lys Phe Ile Thr Arg Ile Tyr Pro Lys
            260                 265                 270         
Ala Thr Arg Ala Asp Ser Ser Asn Phe Asn Pro Gln Glu Phe Trp Asn
        275                 280                 285             
Ile Gly Cys Gln Met Val Ala Leu Asn Phe Gln Thr Pro Gly Leu Pro
    290                 295                 300                 
Met Asp Leu Gln Asn Gly Lys Phe Leu Asp Asn Gly Gly Ser Gly Tyr
305                 310                 315                 320 
Ile Leu Lys Pro His Phe Leu Arg Glu Ser Lys Ser Tyr Phe Asn Pro
                325                 330                 335     
Ser Asn Ile Lys Glu Gly Met Pro Ile Thr Leu Thr Ile Arg Leu Ile
            340                 345                 350         
Ser Gly Ile Gln Leu Pro Leu Thr His Ser Ser Ser Asn Lys Gly Asp
        355                 360                 365             
Ser Leu Val Ile Ile Glu Val Phe Gly Val Pro Asn Asp Gln Met Lys
    370                 375                 380                 
Gln Gln Thr Arg Val Ile Lys Lys Asn Gly Gln Gly Asn Met Val Ile
385                 390                 395                 400 
Ile Pro Ala
            


<210> 7367
<211> 608
<212> PRT
<213> Homo sapiens

<400> 7367
Met Glu Met Arg Trp Phe Leu Ser Lys Ile Gln Asp Asp Phe Arg Gly
 1               5                  10                  15      
Gly Lys Ile Asn Leu Glu Lys Thr Gln Arg Leu Leu Glu Lys Leu Asp
            20                  25                  30          
Ile Arg Cys Ser Tyr Ile His Val Lys Gln Ile Phe Lys Asp Asn Asp
        35                  40                  45              
Arg Leu Lys Gln Gly Arg Ile Thr Ile Glu Glu Phe Arg Ala Ile Tyr
    50                  55                  60                  
Arg Ile Ile Thr His Arg Glu Glu Ile Ile Glu Ile Phe Asn Thr Tyr
65                  70                  75                  80  
Ser Glu Asn Arg Lys Ile Leu Leu Ala Ser Asn Leu Ala Gln Phe Leu
                85                  90                  95      
Thr Gln Glu Gln Tyr Ala Ala Glu Met Ser Lys Ala Ile Ala Phe Glu
            100                 105                 110         
Ile Ile Gln Lys Tyr Glu Pro Ile Glu Glu Val Arg Lys Ala His Gln
        115                 120                 125             
Met Ser Leu Glu Gly Phe Thr Arg Tyr Met Asp Ser Arg Glu Cys Leu
    130                 135                 140                 
Leu Phe Lys Asn Glu Cys Arg Lys Val Tyr Gln Asp Met Thr His Pro
145                 150                 155                 160 
Leu Asn Asp Tyr Phe Ile Ser Ser Ser His Asn Thr Tyr Leu Val Ser
                165                 170                 175     
Asp Gln Leu Leu Gly Pro Ser Asp Leu Trp Gly Tyr Val Ser Ala Leu
            180                 185                 190         
Val Lys Gly Cys Arg Cys Leu Glu Ile Asp Cys Trp Asp Gly Ala Gln
        195                 200                 205             
Asn Glu Pro Val Val Tyr His Gly Tyr Thr Leu Thr Ser Lys Leu Leu
    210                 215                 220                 
Phe Lys Thr Val Ile Gln Ala Ile His Lys Tyr Ala Phe Met Thr Ser
225                 230                 235                 240 
Asp Tyr Pro Val Val Leu Ser Leu Glu Asn His Cys Ser Thr Ala Gln
                245                 250                 255     
Gln Glu Val Met Ala Asp Asn Leu Gln Ala Thr Phe Gly Glu Ser Leu
            260                 265                 270         
Leu Ser Asp Met Leu Asp Asp Phe Pro Asp Thr Leu Pro Ser Pro Glu
        275                 280                 285             
Ala Leu Lys Phe Lys Ile Leu Val Lys Asn Lys Lys Ile Gly Thr Leu
    290                 295                 300                 
Lys Glu Thr His Glu Arg Lys Gly Ser Asp Lys Arg Gly Asp Asn Gln
305                 310                 315                 320 
Asp Lys Glu Thr Gly Val Lys Lys Leu Pro Gly Val Met Leu Phe Lys
                325                 330                 335     
Lys Lys Lys Thr Arg Lys Leu Lys Ile Ala Leu Ala Leu Ser Asp Leu
            340                 345                 350         
Val Ile Tyr Thr Lys Ala Glu Lys Phe Lys Ser Phe Gln His Ser Arg
        355                 360                 365             
Leu Tyr Gln Gln Phe Asn Glu Asn Asn Ser Ile Gly Glu Thr Gln Ala
    370                 375                 380                 
Arg Lys Leu Ser Lys Leu Arg Val His Glu Phe Ile Phe His Thr Arg
385                 390                 395                 400 
Lys Phe Ile Thr Arg Ile Tyr Pro Lys Ala Thr Arg Ala Asp Ser Ser
                405                 410                 415     
Asn Phe Asn Pro Gln Glu Phe Trp Asn Ile Gly Cys Gln Met Val Ala
            420                 425                 430         
Leu Asn Phe Gln Thr Pro Gly Leu Pro Met Asp Leu Gln Asn Gly Lys
        435                 440                 445             
Phe Leu Asp Asn Gly Gly Ser Gly Tyr Ile Leu Lys Pro His Phe Leu
    450                 455                 460                 
Arg Glu Ser Lys Ser Tyr Phe Asn Pro Ser Asn Ile Lys Glu Gly Met
465                 470                 475                 480 
Pro Ile Thr Leu Thr Ile Arg Leu Ile Ser Gly Ile Gln Leu Pro Leu
                485                 490                 495     
Thr His Ser Ser Ser Asn Lys Gly Asp Ser Leu Val Ile Ile Glu Val
            500                 505                 510         
Phe Gly Val Pro Asn Asp Gln Met Lys Gln Gln Thr Arg Val Ile Lys
        515                 520                 525             
Lys Asn Ala Phe Ser Pro Arg Trp Asn Glu Thr Phe Thr Phe Ile Ile
    530                 535                 540                 
His Val Pro Glu Leu Ala Leu Ile Arg Phe Val Val Glu Gly Gln Gly
545                 550                 555                 560 
Leu Ile Ala Gly Asn Glu Phe Leu Gly Gln Tyr Thr Leu Pro Leu Leu
                565                 570                 575     
Cys Met Asn Lys Gly Tyr Arg Arg Ile Pro Leu Phe Ser Arg Met Gly
            580                 585                 590         
Glu Ser Leu Glu Pro Ala Ser Leu Phe Val Tyr Val Trp Tyr Val Arg
        595                 600                 605             


<210> 7368
<211> 390
<212> PRT
<213> Homo sapiens

<400> 7368
Met Ala Asp Asn Leu Gln Ala Thr Phe Gly Glu Ser Leu Leu Ser Asp
 1               5                  10                  15      
Met Leu Asp Asp Phe Pro Asp Thr Leu Pro Ser Pro Glu Ala Leu Lys
            20                  25                  30          
Phe Lys Ile Leu Val Lys Asn Lys Lys Ile Gly Thr Leu Lys Glu Thr
        35                  40                  45              
His Glu Arg Lys Gly Ser Asp Lys Arg Gly Lys Val Glu Glu Trp Glu
    50                  55                  60                  
Glu Glu Val Ala Asp Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
65                  70                  75                  80  
Glu Glu Glu Glu Glu Asp Lys Phe Lys Glu Ser Glu Val Leu Glu Ser
                85                  90                  95      
Val Leu Gly Asp Asn Gln Asp Lys Glu Thr Gly Val Lys Lys Leu Pro
            100                 105                 110         
Gly Val Met Leu Phe Lys Lys Lys Lys Thr Arg Lys Leu Lys Ile Ala
        115                 120                 125             
Leu Ala Leu Ser Asp Leu Val Ile Tyr Thr Lys Ala Glu Lys Phe Lys
    130                 135                 140                 
Ser Phe Gln His Ser Arg Leu Tyr Gln Gln Phe Asn Glu Asn Asn Ser
145                 150                 155                 160 
Ile Gly Glu Thr Gln Ala Arg Lys Leu Ser Lys Leu Arg Val His Glu
                165                 170                 175     
Phe Ile Phe His Thr Arg Lys Phe Ile Thr Arg Ile Tyr Pro Lys Ala
            180                 185                 190         
Thr Arg Ala Asp Ser Ser Asn Phe Asn Pro Gln Glu Phe Trp Asn Ile
        195                 200                 205             
Gly Cys Gln Met Val Ala Leu Asn Phe Gln Thr Pro Gly Leu Pro Met
    210                 215                 220                 
Asp Leu Gln Asn Gly Lys Phe Leu Asp Asn Gly Gly Ser Gly Tyr Ile
225                 230                 235                 240 
Leu Lys Pro His Phe Leu Arg Glu Ser Lys Ser Tyr Phe Asn Pro Ser
                245                 250                 255     
Asn Ile Lys Glu Gly Met Pro Ile Thr Leu Thr Ile Arg Leu Ile Ser
            260                 265                 270         
Gly Ile Gln Leu Pro Leu Thr His Ser Ser Ser Asn Lys Gly Asp Ser
        275                 280                 285             
Leu Val Ile Ile Glu Val Phe Gly Val Pro Asn Asp Gln Met Lys Gln
    290                 295                 300                 
Gln Thr Arg Val Ile Lys Lys Asn Ala Phe Ser Pro Arg Trp Asn Glu
305                 310                 315                 320 
Thr Phe Thr Phe Ile Ile His Val Pro Glu Leu Ala Leu Ile Arg Phe
                325                 330                 335     
Val Val Glu Gly Gln Gly Leu Ile Ala Gly Asn Glu Phe Leu Gly Gln
            340                 345                 350         
Tyr Thr Leu Pro Leu Leu Cys Met Asn Lys Gly Tyr Arg Arg Ile Pro
        355                 360                 365             
Leu Phe Ser Arg Met Gly Glu Ser Leu Glu Pro Ala Ser Leu Phe Val
    370                 375                 380                 
Tyr Val Trp Tyr Val Arg
385                 390 


<210> 7369
<211> 1046
<212> PRT
<213> Homo sapiens

<400> 7369
Leu Leu Pro Lys Met Ala Asp Ala Phe Gly Asp Glu Leu Phe Ser Val
 1               5                  10                  15      
Phe Glu Gly Asp Ser Thr Thr Ala Ala Gly Thr Lys Lys Asp Lys Glu
            20                  25                  30          
Lys Asp Lys Gly Lys Trp Lys Gly Pro Pro Gly Ser Ala Asp Lys Ala
        35                  40                  45              
Gly Lys Arg Phe Asp Gly Lys Leu Gln Ser Glu Ser Thr Asn Asn Gly
    50                  55                  60                  
Lys Asn Lys Arg Asp Val Asp Phe Glu Gly Thr Asp Glu Pro Ile Phe
65                  70                  75                  80  
Gly Lys Lys Pro Arg Ile Glu Glu Ser Ile Thr Glu Asp Leu Ser Leu
                85                  90                  95      
Ala Asp Leu Met Pro Arg Val Lys Val Gln Ser Val Glu Thr Val Glu
            100                 105                 110         
Gly Cys Thr His Glu Val Ala Leu Pro Ala Glu Glu Asp Tyr Leu Pro
        115                 120                 125             
Leu Lys Pro Arg Val Gly Lys Ala Ala Lys Glu Tyr Pro Phe Ile Leu
    130                 135                 140                 
Asp Ala Phe Gln Arg Glu Ala Ile Gln Cys Val Asp Asn Asn Gln Ser
145                 150                 155                 160 
Val Leu Val Ser Ala His Thr Ser Ala Gly Lys Thr Val Cys Ala Glu
                165                 170                 175     
Tyr Ala Ile Ala Leu Ala Leu Arg Glu Lys Gln Arg Val Ile Phe Thr
            180                 185                 190         
Ser Pro Ile Lys Ala Leu Ser Asn Gln Lys Tyr Arg Glu Met Tyr Glu
        195                 200                 205             
Glu Phe Gln Asp Val Gly Leu Met Thr Gly Asp Val Thr Ile Asn Pro
    210                 215                 220                 
Thr Ala Ser Cys Leu Val Met Thr Thr Glu Ile Leu Arg Ser Met Leu
225                 230                 235                 240 
Tyr Arg Gly Ser Glu Val Met Arg Glu Val Ala Trp Val Ile Phe Asp
                245                 250                 255     
Glu Ile His Tyr Met Arg Asp Ser Glu Arg Gly Val Val Trp Glu Glu
            260                 265                 270         
Thr Ile Ile Leu Leu Pro Asp Asn Val His Tyr Val Phe Leu Ser Ala
        275                 280                 285             
Thr Ile Pro Asn Ala Arg Gln Phe Ala Glu Trp Ile Cys His Leu His
    290                 295                 300                 
Lys Gln Pro Cys His Val Ile Tyr Thr Asp Tyr Arg Pro Thr Pro Leu
305                 310                 315                 320 
Gln His Tyr Ile Phe Pro Ala Gly Gly Asp Gly Leu His Leu Val Val
                325                 330                 335     
Asp Glu Asn Gly Asp Phe Arg Glu Asp Asn Phe Asn Thr Ala Met Gln
            340                 345                 350         
Val Leu Arg Asp Ala Gly Asp Leu Ala Lys Gly Asp Gln Lys Gly Arg
        355                 360                 365             
Lys Gly Gly Thr Lys Gly Pro Ser Asn Val Phe Lys Ile Val Lys Met
    370                 375                 380                 
Ile Met Glu Arg Asn Phe Gln Pro Val Ile Ile Phe Ser Phe Ser Lys
385                 390                 395                 400 
Lys Asp Cys Glu Ala Tyr Ala Leu Gln Met Thr Lys Leu Asp Phe Asn
                405                 410                 415     
Thr Asp Glu Glu Lys Lys Met Val Glu Glu Val Phe Ser Asn Ala Ile
            420                 425                 430         
Asp Cys Leu Ser Asp Glu Asp Lys Lys Leu Pro Gln Val Glu His Val
        435                 440                 445             
Leu Pro Leu Leu Lys Arg Gly Ile Gly Ile His His Gly Gly Leu Leu
    450                 455                 460                 
Pro Ile Leu Lys Glu Thr Ile Glu Ile Leu Phe Ser Glu Gly Leu Ile
465                 470                 475                 480 
Lys Ala Leu Phe Ala Thr Glu Thr Phe Ala Met Gly Ile Asn Met Pro
                485                 490                 495     
Ala Arg Thr Val Leu Phe Thr Asn Ala Arg Lys Phe Asp Gly Lys Asp
            500                 505                 510         
Phe Arg Trp Ile Ser Ser Gly Glu Tyr Ile Gln Met Ser Gly Arg Ala
        515                 520                 525             
Gly Arg Arg Gly Met Asp Asp Arg Gly Ile Val Ile Leu Met Val Asp
    530                 535                 540                 
Glu Lys Met Ser Pro Thr Ile Gly Lys Gln Leu Leu Lys Gly Ser Ala
545                 550                 555                 560 
Asp Pro Leu Asn Ser Ala Phe His Leu Thr Tyr Asn Met Val Leu Asn
                565                 570                 575     
Leu Leu Arg Val Glu Glu Ile Asn Pro Glu Tyr Met Leu Glu Lys Ser
            580                 585                 590         
Phe Tyr Gln Phe Gln His Tyr Arg Ala Ile Pro Gly Val Val Glu Lys
        595                 600                 605             
Val Lys Asn Ser Glu Glu Gln Tyr Asn Lys Ile Val Ile Pro Asn Glu
    610                 615                 620                 
Glu Ser Val Val Ile Tyr Tyr Lys Ile Arg Gln Gln Leu Ala Lys Leu
625                 630                 635                 640 
Gly Lys Glu Ile Glu Glu Tyr Ile His Lys Pro Lys Tyr Cys Leu Pro
                645                 650                 655     
Phe Leu Gln Pro Gly Arg Leu Val Lys Val Lys Asn Glu Gly Asp Asp
            660                 665                 670         
Phe Gly Trp Gly Val Val Val Asn Phe Ser Lys Lys Ser Asn Val Lys
        675                 680                 685             
Pro Asn Ser Gly Glu Leu Asp Pro Leu Tyr Val Val Glu Val Leu Leu
    690                 695                 700                 
Arg Cys Ser Lys Glu Ser Leu Lys Asn Ser Ala Thr Glu Ala Ala Lys
705                 710                 715                 720 
Pro Ala Lys Pro Asp Glu Lys Gly Glu Met Gln Val Val Pro Val Leu
                725                 730                 735     
Val His Leu Leu Ser Ala Ile Ser Ser Val Arg Leu Tyr Ile Pro Lys
            740                 745                 750         
Asp Leu Arg Pro Val Asp Asn Arg Gln Ser Val Leu Lys Ser Ile Gln
        755                 760                 765             
Glu Val Gln Lys Arg Phe Pro Asp Gly Ile Pro Leu Leu Asp Pro Ile
    770                 775                 780                 
Asp Asp Met Gly Ile Gln Asp Gln Gly Leu Lys Lys Val Ile Gln Lys
785                 790                 795                 800 
Val Glu Ala Phe Glu His Arg Met Tyr Ser His Pro Leu His Asn Asp
                805                 810                 815     
Pro Asn Leu Glu Thr Val Tyr Thr Leu Cys Glu Lys Lys Ala Gln Ile
            820                 825                 830         
Ala Ile Asp Ile Lys Ser Ala Lys Arg Glu Leu Lys Lys Ala Arg Thr
        835                 840                 845             
Val Leu Gln Met Asp Glu Leu Lys Cys Arg Lys Arg Val Leu Arg Arg
    850                 855                 860                 
Leu Gly Phe Ala Thr Ser Ser Asp Val Ile Glu Met Lys Gly Arg Val
865                 870                 875                 880 
Ala Cys Glu Ile Ser Ser Ala Asp Glu Leu Leu Leu Thr Glu Met Met
                885                 890                 895     
Phe Asn Gly Leu Phe Asn Asp Leu Ser Ala Glu Gln Ala Thr Ala Leu
            900                 905                 910         
Leu Ser Cys Phe Val Phe Gln Glu Asn Ser Ser Glu Met Pro Lys Leu
        915                 920                 925             
Thr Glu Gln Leu Ala Gly Pro Leu Arg Gln Met Gln Glu Cys Ala Lys
    930                 935                 940                 
Arg Ile Ala Lys Val Ser Ala Glu Ala Lys Leu Glu Ile Asp Glu Glu
945                 950                 955                 960 
Thr Tyr Leu Ser Ser Phe Lys Pro His Leu Met Asp Val Val Tyr Thr
                965                 970                 975     
Trp Ala Thr Gly Ala Thr Phe Ala His Ile Cys Lys Met Thr Asp Val
            980                 985                 990         
Phe Glu Gly Ser Ile Ile Arg Cys Met Arg Arg Leu Glu Glu Leu Leu
        995                 1000                1005            
Arg Gln Met Cys Gln Ala Ala Lys Ala Ile Gly Asn Thr Glu Leu Glu
    1010                1015                1020                
Asn Lys Phe Ala Glu Gly Ile Thr Lys Ile Lys Arg Asp Ile Val Phe
1025                1030                1035                1040
Ala Ala Ser Leu Tyr Leu
                1045    


<210> 7370
<211> 1585
<212> PRT
<213> Homo sapiens

<400> 7370
Met Gly Arg Ser Thr Lys Leu Val Ile Ile Glu Arg Leu Leu Leu Leu
 1               5                  10                  15      
Ala Glu Arg Tyr Val Ile Thr Ile Glu Ala His Ser Asn Glu Thr Ile
            20                  25                  30          
Gly Ser Val Arg Trp Lys Ile Ala Lys Gln Leu Cys Ser Pro Val Asp
        35                  40                  45              
Asn Ile Gln Ile Phe Thr Asn Asp Ser Leu Leu Thr Val Asn Lys Asp
    50                  55                  60                  
Gln Lys Leu Leu His Gln Leu Gly Phe Ser Asp Glu Gln Ile Leu Thr
65                  70                  75                  80  
Val Lys Thr Ser Gly Ser Gly Thr Pro Ser Gly Ser Ser Ala Asp Ser
                85                  90                  95      
Ser Thr Ser Ser Ser Ser Ser Ser Ser Gly Val Phe Ser Ser Ser Tyr
            100                 105                 110         
Ala Met Glu Gln Glu Lys Ser Leu Pro Gly Val Val Met Ala Leu Val
        115                 120                 125             
Cys Asn Val Phe Asp Met Leu Tyr Gln Leu Ala Asn Leu Glu Glu Pro
    130                 135                 140                 
Arg Ile Thr Leu Arg Val Arg Lys Leu Leu Leu Leu Ile Pro Thr Asp
145                 150                 155                 160 
Pro Ala Ile Gln Glu Ala Leu Asp Gln Leu Asp Ser Leu Gly Arg Lys
                165                 170                 175     
Val Leu Ser Ser Lys Leu Met Pro Thr Ala Asp Asp Asp Met Ala Arg
            180                 185                 190         
Ser Cys Ala Lys Ser Phe Cys Glu Asn Phe Leu Lys Ala Gly Gly Leu
        195                 200                 205             
Arg Phe Leu Leu Val Gly Gln Thr Met Pro Thr Leu Leu Asp Glu Asp
    210                 215                 220                 
Leu Thr Lys Asp Gly Ile Glu Ala Leu Ser Ser Arg Pro Phe Arg Asn
225                 230                 235                 240 
Val Ser Arg Gln Thr Ser Arg Gln Met Ser Leu Cys Gly Thr Pro Glu
                245                 250                 255     
Lys Ser Ser Tyr Arg Gln Leu Ser Val Ser Asp Arg Ser Ser Ile Arg
            260                 265                 270         
Val Glu Glu Ile Ile Pro Ala Ala Arg Val Ala Ile Gln Thr Met Glu
        275                 280                 285             
Val Ser Asp Phe Thr Ser Thr Val Ala Cys Phe Met Arg Leu Ser Trp
    290                 295                 300                 
Ala Ala Ala Ala Gly Arg Leu Asp Leu Val Gly Ser Ser Gln Pro Ile
305                 310                 315                 320 
Lys Glu Ser Asn Ser Leu Cys Pro Ala Gly Ile Arg Asn Arg Leu Ser
                325                 330                 335     
Ser Ser Gly Ser Asn Cys Ser Ser Gly Ser Glu Gly Glu Pro Val Ala
            340                 345                 350         
Leu His Ala Gly Ile Cys Val Arg Gln Gln Ser Val Ser Thr Lys Asp
        355                 360                 365             
Ser Leu Ile Ala Gly Glu Ala Leu Ser Leu Leu Val Thr Cys Leu Gln
    370                 375                 380                 
Leu Arg Ser Gln Gln Leu Ala Ser Phe Tyr Asn Leu Pro Cys Val Ala
385                 390                 395                 400 
Asp Phe Ile Ile Asp Ile Leu Leu Gly Ser Pro Ser Ala Glu Ile Arg
                405                 410                 415     
Arg Val Ala Cys Asp Gln Leu Tyr Thr Leu Ser Gln Thr Asp Thr Ser
            420                 425                 430         
Ala His Pro Asp Val Gln Lys Pro Asn Gln Phe Leu Leu Gly Val Ile
        435                 440                 445             
Leu Thr Ala Gln Leu Pro Leu Trp Ser Pro Thr Ser Ile Met Arg Gly
    450                 455                 460                 
Val Asn Gln Arg Leu Leu Ser Gln Cys Met Glu Tyr Phe Asp Leu Arg
465                 470                 475                 480 
Cys Gln Leu Leu Asp Asp Leu Thr Thr Ser Glu Met Glu Gln Leu Arg
                485                 490                 495     
Ile Ser Pro Ala Thr Met Leu Glu Asp Glu Ile Thr Trp Leu Asp Asn
            500                 505                 510         
Phe Glu Pro Asn Arg Thr Ala Glu Cys Glu Thr Ser Glu Ala Asp Asn
        515                 520                 525             
Ile Leu Leu Ala Gly His Leu Arg Leu Ile Lys Thr Leu Leu Ser Leu
    530                 535                 540                 
Cys Gly Ala Glu Lys Glu Met Leu Gly Ser Ser Leu Ile Lys Pro Leu
545                 550                 555                 560 
Leu Asp Asp Phe Leu Phe Arg Ala Ser Arg Ile Ile Leu Asn Ser His
                565                 570                 575     
Ser Pro Ala Gly Ser Ala Ala Ile Ser Gln Gln Asp Phe His Pro Lys
            580                 585                 590         
Cys Ser Thr Ala Asn Ser Arg Leu Ala Ala Tyr Glu Val Leu Val Met
        595                 600                 605             
Leu Ala Asp Ser Ser Pro Ser Asn Leu Gln Ile Ile Ile Lys Glu Leu
    610                 615                 620                 
Leu Ser Met His His Gln Pro Asp Pro Ala Leu Thr Lys Glu Phe Asp
625                 630                 635                 640 
Tyr Leu Pro Pro Val Asp Ser Arg Ser Ser Ser Gly Phe Val Gly Leu
                645                 650                 655     
Arg Asn Gly Gly Ala Thr Cys Tyr Met Asn Ala Val Phe Gln Gln Leu
            660                 665                 670         
Tyr Met Gln Pro Gly Leu Pro Glu Ser Leu Leu Ser Val Asp Asp Asp
        675                 680                 685             
Thr Asp Asn Pro Asp Asp Ser Val Phe Tyr Gln Val Gln Ser Leu Phe
    690                 695                 700                 
Gly His Leu Met Glu Ser Lys Leu Gln Tyr Tyr Val Pro Glu Asn Phe
705                 710                 715                 720 
Trp Lys Ile Phe Lys Met Trp Asn Lys Glu Leu Tyr Val Arg Glu Gln
                725                 730                 735     
Gln Asp Ala Tyr Glu Phe Phe Thr Ser Leu Ile Asp Gln Met Asp Glu
            740                 745                 750         
Tyr Leu Lys Lys Met Gly Arg Asp Gln Ile Phe Lys Asn Thr Phe Gln
        755                 760                 765             
Gly Ile Tyr Ser Asp Gln Lys Ile Cys Lys Asp Cys Pro His Arg Tyr
    770                 775                 780                 
Glu Arg Glu Glu Ala Phe Met Ala Leu Asn Leu Gly Val Thr Ser Cys
785                 790                 795                 800 
Gln Ser Leu Glu Ile Ser Leu Asp Gln Phe Val Arg Gly Glu Val Leu
                805                 810                 815     
Glu Gly Ser Asn Ala Tyr Tyr Cys Glu Lys Cys Lys Glu Lys Arg Ile
            820                 825                 830         
Thr Val Lys Arg Thr Cys Ile Lys Ser Leu Pro Ser Val Leu Val Ile
        835                 840                 845             
His Leu Met Arg Phe Gly Phe Asp Trp Glu Ser Gly Arg Ser Ile Lys
    850                 855                 860                 
Tyr Asp Glu Gln Ile Arg Phe Pro Trp Met Leu Asn Met Glu Pro Tyr
865                 870                 875                 880 
Thr Val Ser Gly Met Ala Arg Gln Asp Ser Ser Ser Glu Val Gly Glu
                885                 890                 895     
Asn Gly Arg Ser Val Asp Gln Gly Gly Gly Gly Ser Pro Arg Lys Lys
            900                 905                 910         
Val Ala Leu Thr Glu Asn Tyr Glu Leu Val Gly Val Ile Val His Ser
        915                 920                 925             
Gly Gln Ala His Ala Gly His Tyr Tyr Ser Phe Ile Lys Asp Arg Arg
    930                 935                 940                 
Gly Cys Gly Lys Gly Lys Trp Tyr Lys Phe Asn Asp Thr Val Ile Glu
945                 950                 955                 960 
Glu Phe Asp Leu Asn Asp Glu Thr Leu Glu Tyr Glu Cys Phe Gly Gly
                965                 970                 975     
Glu Tyr Arg Pro Lys Val Tyr Asp Gln Thr Asn Pro Tyr Thr Asp Val
            980                 985                 990         
Arg Arg Arg Tyr Trp Asn Ala Tyr Met Leu Phe Tyr Gln Arg Val Ser
        995                 1000                1005            
Asp Gln Asn Ser Pro Val Leu Pro Lys Lys Ser Arg Val Ser Val Val
    1010                1015                1020                
Arg Gln Glu Ala Glu Asp Leu Ser Leu Ser Ala Pro Ser Ser Pro Glu
1025                1030                1035                1040
Ile Ser Pro Gln Ser Ser Pro Arg Pro His Arg Pro Asn Asn Asp Arg
                1045                1050                1055    
Leu Ser Ile Leu Thr Lys Leu Val Lys Lys Gly Glu Lys Lys Gly Leu
            1060                1065                1070        
Phe Val Glu Lys Met Pro Ala Arg Ile Tyr Gln Met Val Arg Asp Glu
        1075                1080                1085            
Asn Leu Lys Phe Met Lys Asn Arg Asp Val Tyr Ser Ser Asp Tyr Phe
    1090                1095                1100                
Ser Phe Val Leu Ser Leu Ala Ser Leu Asn Ala Thr Lys Leu Lys His
1105                1110                1115                1120
Pro Tyr Tyr Pro Cys Met Ala Lys Val Ser Leu Gln Leu Ala Ile Gln
                1125                1130                1135    
Phe Leu Phe Gln Thr Tyr Leu Arg Thr Lys Lys Lys Leu Arg Val Asp
            1140                1145                1150        
Thr Glu Glu Trp Ile Ala Thr Ile Glu Ala Leu Leu Ser Lys Ser Phe
        1155                1160                1165            
Asp Ala Cys Gln Trp Leu Val Glu Tyr Phe Ile Ser Ser Glu Gly Arg
    1170                1175                1180                
Glu Leu Ile Lys Ile Phe Leu Leu Glu Cys Asn Val Arg Glu Val Arg
1185                1190                1195                1200
Val Ala Val Ala Thr Ile Leu Glu Lys Thr Leu Asp Ser Ala Leu Phe
                1205                1210                1215    
Tyr Gln Asp Lys Leu Lys Ser Leu His Gln Leu Leu Glu Val Leu Leu
            1220                1225                1230        
Ala Leu Leu Asp Lys Asp Val Pro Glu Asn Cys Lys Asn Cys Ala Gln
        1235                1240                1245            
Tyr Phe Phe Leu Phe Asn Thr Phe Val Gln Lys Gln Gly Ile Arg Ala
    1250                1255                1260                
Gly Asp Leu Leu Leu Arg His Ser Ala Leu Arg His Met Ile Ser Phe
1265                1270                1275                1280
Leu Leu Gly Ala Ser Arg Gln Asn Asn Gln Ile Arg Arg Trp Ser Ser
                1285                1290                1295    
Ala Gln Ala Arg Glu Phe Gly Asn Leu His Asn Thr Val Ala Leu Leu
            1300                1305                1310        
Val Leu His Ser Asp Val Ser Ser Gln Arg Asn Val Ala Pro Gly Ile
        1315                1320                1325            
Phe Lys Gln Arg Pro Pro Ile Ser Ile Ala Pro Ser Ser Pro Leu Leu
    1330                1335                1340                
Pro Leu His Glu Glu Val Glu Ala Leu Leu Phe Met Ser Glu Gly Lys
1345                1350                1355                1360
Pro Tyr Leu Leu Glu Val Met Phe Ala Leu Arg Glu Leu Thr Gly Ser
                1365                1370                1375    
Leu Leu Ala Leu Ile Glu Met Val Val Tyr Cys Cys Phe Cys Asn Glu
            1380                1385                1390        
His Phe Ser Phe Thr Met Leu His Phe Ile Lys Asn Gln Leu Glu Thr
        1395                1400                1405            
Ala Pro Pro His Glu Leu Lys Asn Thr Phe Gln Leu Leu His Glu Ile
    1410                1415                1420                
Leu Val Ile Glu Asp Pro Ile Gln Val Glu Arg Val Lys Phe Val Phe
1425                1430                1435                1440
Glu Thr Glu Asn Gly Leu Leu Ala Leu Met His His Ser Asn His Val
                1445                1450                1455    
Asp Ser Ser Arg Cys Tyr Gln Cys Val Lys Phe Leu Val Thr Leu Ala
            1460                1465                1470        
Gln Lys Cys Pro Ala Ala Lys Glu Tyr Phe Lys Glu Asn Ser His His
        1475                1480                1485            
Trp Ser Trp Ala Val Gln Trp Leu Gln Lys Lys Met Ser Glu His Tyr
    1490                1495                1500                
Trp Thr Pro Gln Ser Asn Val Ser Asn Glu Thr Ser Thr Gly Lys Thr
1505                1510                1515                1520
Phe Gln Arg Thr Ile Ser Ala Gln Asp Thr Leu Ala Tyr Ala Thr Ala
                1525                1530                1535    
Leu Leu Asn Glu Lys Glu Gln Ser Gly Ser Ser Asn Gly Ser Glu Ser
            1540                1545                1550        
Ser Pro Ala Asn Glu Asn Gly Asp Arg His Leu Gln Gln Gly Ser Glu
        1555                1560                1565            
Ser Pro Met Met Ile Gly Glu Leu Arg Ser Asp Leu Asp Asp Val Asp
    1570                1575                1580                
Pro
1585


<210> 7371
<211> 632
<212> PRT
<213> Homo sapiens

<400> 7371
Met Ser Ser Lys Asn Ser Glu Ser Gly Thr Ala Thr Thr Gly Thr Ser
 1               5                  10                  15      
Leu Ser Ala Pro Asp Ile Thr Val Arg Asn Val Val Asn Ile Ala Arg
            20                  25                  30          
Pro Ser Ser Gln Gln Ser Ser Trp Thr Ser Ala Asn Asn Asp Val Ile
        35                  40                  45              
Val Thr Gly Ile Tyr Ser Pro Ala Ser Ser Ser Ser Arg Gln Gly Thr
    50                  55                  60                  
Asn Lys His Thr Asp Thr Gln Ile Thr Glu Ala His Lys Ile Pro Ile
65                  70                  75                  80  
Gln Lys Thr Ala Thr Lys Asn Asp Thr Glu Phe Gln Leu His Ile Pro
                85                  90                  95      
Val Gln Arg Gln Val Ala His Cys Lys Asn Ala Ser Leu Leu Leu Gly
            100                 105                 110         
Glu Lys Thr Ile Ile Leu Ser Arg Gln Thr Ser Val Leu Asn Ala Gly
        115                 120                 125             
Asn Ser Val Phe Asn His Ala Lys Lys Asn Tyr Gly Asn Ser Ser Val
    130                 135                 140                 
Gln Ala Ser Glu Met Thr Val Pro Gln Lys Pro Ser Val Cys His Arg
145                 150                 155                 160 
Pro Cys Lys Ile Glu Pro Val Gly Ile Gln Arg Ser Tyr Lys Pro Glu
                165                 170                 175     
His Thr Gly Pro Ala Leu His Asn Leu Cys Gly Gln Lys Pro Thr Ile
            180                 185                 190         
Arg Asp Pro Tyr Cys Arg Thr Gln Asn Leu Glu Ile Arg Glu Val Phe
        195                 200                 205             
Ser Leu Ala Val Ser Asp Tyr Pro Gln Arg Ile Leu Gly Gly Asn Ala
    210                 215                 220                 
Pro Gln Lys Pro Ser Ser Ala Glu Gly Asn Cys Leu Ser Ile Ala Met
225                 230                 235                 240 
Glu Thr Gly Asp Ala Glu Asp Glu Tyr Ala Arg Glu Glu Glu Leu Ala
                245                 250                 255     
Ser Met Arg Ala Gln Ile Pro Ser Tyr Ser Arg Phe Tyr Glu Ser Gly
            260                 265                 270         
Ser Ser Leu Arg Ala Glu Asn Gln Ser Thr Thr Leu Pro Gly Pro Gly
        275                 280                 285             
Arg Asn Met Pro Asn Ser Gln Met Val Asn Ile Arg Asp Met Ser Asp
    290                 295                 300                 
Asn Val Leu Tyr Gln Asn Arg Asn Tyr His Leu Thr Pro Arg Thr Ser
305                 310                 315                 320 
Leu His Thr Ala Ser Ser Thr Met Tyr Ser Asn Thr Asn Pro Leu Arg
                325                 330                 335     
Ser Asn Phe Ser Pro His Phe Ala Ser Ser Asn Gln Leu Arg Leu Ser
            340                 345                 350         
Gln Asn Gln Asn Asn Tyr Gln Ile Ser Gly Asn Leu Thr Val Pro Trp
        355                 360                 365             
Ile Thr Gly Cys Ser Arg Lys Arg Ala Leu Gln Asp Arg Thr Gln Phe
    370                 375                 380                 
Ser Asp Arg Asp Leu Ala Thr Leu Lys Lys Tyr Trp Asp Asn Gly Met
385                 390                 395                 400 
Thr Ser Leu Gly Ser Val Cys Arg Glu Lys Ile Glu Ala Val Ala Thr
                405                 410                 415     
Glu Leu Asn Val Asp Cys Glu Ile Val Arg Thr Trp Ile Gly Asn Arg
            420                 425                 430         
Arg Arg Lys Tyr Arg Leu Met Gly Ile Glu Val Pro Pro Pro Arg Gly
        435                 440                 445             
Gly Pro Ala Asp Phe Ser Glu Gln Pro Glu Ser Gly Ser Leu Ser Ala
    450                 455                 460                 
Leu Thr Pro Gly Glu Glu Ala Gly Pro Glu Val Gly Glu Asp Asn Asp
465                 470                 475                 480 
Arg Asn Asp Glu Val Ser Ile Cys Leu Ser Glu Gly Ser Ser Gln Glu
                485                 490                 495     
Glu Pro Asn Glu Val Val Pro Asn Asp Ala Arg Ala His Lys Glu Glu
            500                 505                 510         
Asp His His Ala Val Thr Thr Asp Asn Val Lys Ile Glu Ile Ile Asp
        515                 520                 525             
Asp Glu Glu Ser Asp Met Ile Ser Asn Ser Glu Val Glu Gln Val Asn
    530                 535                 540                 
Ser Phe Leu Asp Tyr Lys Asn Glu Glu Val Lys Phe Ile Glu Asn Glu
545                 550                 555                 560 
Leu Glu Ile Gln Lys Gln Lys Tyr Phe Lys Leu Gln Thr Phe Val Arg
                565                 570                 575     
Ser Leu Ile Leu Ala Met Lys Ala Asp Asp Lys Glu Gln Gln Gln Ala
            580                 585                 590         
Leu Leu Ser Asp Leu Pro Pro Glu Leu Glu Glu Met Asp Phe Asn His
        595                 600                 605             
Ala Ser Leu Glu Pro Asp Asp Thr Ser Phe Ser Val Ser Ser Leu Ser
    610                 615                 620                 
Glu Lys Asn Val Ser Glu Ser Leu
625                 630         


<210> 7372
<211> 1257
<212> PRT
<213> Homo sapiens

<400> 7372
Met Met Cys Glu Val Met Pro Thr Ile Asn Glu Asp Thr Pro Met Ser
 1               5                  10                  15      
Gln Arg Gly Ser Gln Ser Ser Gly Ser Asp Ser Asp Ser His Phe Glu
            20                  25                  30          
Gln Leu Met Val Asn Met Leu Asp Glu Arg Asp Arg Leu Leu Asp Thr
        35                  40                  45              
Leu Arg Glu Thr Gln Glu Ser Leu Ser Leu Ala Gln Gln Arg Leu Gln
    50                  55                  60                  
Asp Val Ile Tyr Asp Arg Asp Ser Leu Gln Arg Gln Leu Asn Ser Ala
65                  70                  75                  80  
Leu Pro Gln Asp Ile Glu Ser Leu Thr Gly Gly Leu Ala Gly Ser Lys
                85                  90                  95      
Gly Ala Asp Pro Pro Glu Phe Ala Ala Leu Thr Lys Glu Leu Asn Ala
            100                 105                 110         
Cys Arg Glu Gln Leu Leu Glu Lys Glu Glu Glu Ile Ser Glu Leu Lys
        115                 120                 125             
Ala Glu Arg Asn Asn Thr Arg Leu Leu Leu Glu His Leu Glu Cys Leu
    130                 135                 140                 
Val Ser Arg His Glu Arg Ser Leu Arg Met Thr Val Val Lys Arg Gln
145                 150                 155                 160 
Ala Gln Ser Pro Ser Gly Val Ser Ser Glu Val Glu Val Leu Lys Ala
                165                 170                 175     
Leu Lys Ser Leu Phe Glu His His Lys Ala Leu Asp Glu Lys Val Arg
            180                 185                 190         
Glu Arg Leu Arg Val Ser Leu Glu Arg Val Ser Ala Leu Glu Glu Glu
        195                 200                 205             
Leu Ala Ala Ala Asn Gln Glu Ile Val Ala Leu Arg Glu Gln Asn Val
    210                 215                 220                 
His Ile Gln Arg Lys Met Ala Ser Ser Glu Gly Ser Thr Glu Ser Glu
225                 230                 235                 240 
His Leu Glu Gly Met Glu Pro Gly Gln Lys Val His Glu Lys Arg Leu
                245                 250                 255     
Ser Asn Gly Ser Ile Asp Ser Thr Asp Glu Thr Ser Gln Ile Val Glu
            260                 265                 270         
Leu Gln Glu Leu Leu Glu Lys Gln Asn Tyr Glu Met Ala Gln Met Lys
        275                 280                 285             
Glu Arg Leu Ala Ala Leu Ser Ser Arg Val Gly Glu Val Glu Gln Glu
    290                 295                 300                 
Ala Glu Thr Ala Arg Lys Asp Leu Ile Lys Thr Glu Glu Met Asn Thr
305                 310                 315                 320 
Lys Tyr Gln Arg Asp Ile Arg Glu Ala Met Ala Gln Lys Glu Asp Met
                325                 330                 335     
Glu Glu Arg Ile Thr Thr Leu Glu Lys Arg Tyr Leu Ser Ala Gln Arg
            340                 345                 350         
Glu Ser Thr Ser Ile His Asp Met Asn Asp Lys Leu Glu Asn Glu Leu
        355                 360                 365             
Ala Asn Lys Glu Ala Ile Leu Arg Gln Met Glu Glu Lys Asn Arg Gln
    370                 375                 380                 
Leu Gln Glu Arg Leu Glu Leu Ala Glu Glu Lys Leu Gln Gln Thr Met
385                 390                 395                 400 
Arg Lys Ala Glu Thr Leu Pro Glu Val Glu Ala Glu Leu Ala Gln Arg
                405                 410                 415     
Ile Ala Ala Leu Thr Lys Ala Glu Glu Thr His Gly Asn Ile Glu Glu
            420                 425                 430         
Arg Met Arg His Leu Glu Gly Gln Leu Glu Glu Lys Asn Gln Glu Leu
        435                 440                 445             
Gln Arg Ala Arg Gln Arg Glu Lys Met Asn Glu Glu His Asn Lys Arg
    450                 455                 460                 
Leu Ser Asp Thr Val Asp Arg Leu Leu Thr Glu Ser Asn Glu Arg Leu
465                 470                 475                 480 
Gln Leu His Leu Lys Glu Arg Met Ala Ala Leu Glu Glu Lys Asn Val
                485                 490                 495     
Leu Ile Gln Glu Ser Glu Thr Phe Arg Lys Asn Leu Glu Glu Ser Leu
            500                 505                 510         
His Asp Lys Glu Ser Leu Ala Glu Glu Ile Glu Lys Leu Arg Ser Glu
        515                 520                 525             
Leu Asp Gln Leu Lys Met Arg Thr Gly Ser Leu Ile Glu Pro Thr Ile
    530                 535                 540                 
Pro Arg Thr His Leu Asp Thr Ser Ala Glu Leu Arg Tyr Ser Val Gly
545                 550                 555                 560 
Ser Leu Val Asp Ser Gln Ser Asp Tyr Arg Thr Thr Lys Val Ile Arg
                565                 570                 575     
Arg Pro Arg Arg Gly Arg Met Gly Val Arg Arg Asp Glu Pro Lys Val
            580                 585                 590         
Lys Ser Leu Gly Asp His Glu Trp Asn Arg Thr Gln Gln Ile Gly Val
        595                 600                 605             
Leu Ser Ser His Pro Phe Glu Ser Asp Thr Glu Met Ser Asp Ile Asp
    610                 615                 620                 
Asp Asp Asp Arg Glu Thr Ile Phe Ser Ser Met Asp Leu Leu Ser Pro
625                 630                 635                 640 
Ser Gly His Ser Asp Ala Gln Thr Leu Ala Met Met Leu Gln Glu Gln
                645                 650                 655     
Leu Asp Ala Ile Asn Lys Glu Ile Arg Leu Ile Gln Glu Glu Lys Glu
            660                 665                 670         
Ser Thr Glu Leu Arg Ala Glu Glu Ile Glu Asn Arg Val Ala Ser Val
        675                 680                 685             
Ser Leu Glu Gly Leu Asn Leu Ala Met Val His Pro Gly Thr Ser Ile
    690                 695                 700                 
Thr Ala Ser Val Thr Ala Ser Ser Leu Ala Ser Ser Ser Pro Pro Ser
705                 710                 715                 720 
Gly His Ser Thr Pro Lys Leu Thr Pro Arg Ser Pro Ala Arg Glu Met
                725                 730                 735     
Asp Arg Met Gly Val Met Thr Leu Pro Ser Asp Leu Arg Lys His Arg
            740                 745                 750         
Arg Lys Ile Ala Val Val Glu Glu Asp Gly Arg Glu Asp Lys Ala Thr
        755                 760                 765             
Ile Lys Cys Glu Thr Ser Pro Pro Pro Thr Pro Arg Ala Leu Arg Met
    770                 775                 780                 
Thr His Thr Leu Pro Ser Ser Tyr His Asn Asp Ala Arg Ser Ser Leu
785                 790                 795                 800 
Ser Val Ser Leu Glu Pro Glu Ser Leu Gly Leu Gly Ser Ala Asn Ser
                805                 810                 815     
Ser Gln Asp Ser Leu His Lys Ala Pro Lys Lys Lys Gly Ile Lys Ser
            820                 825                 830         
Ser Ile Gly Arg Leu Phe Gly Lys Lys Glu Lys Ala Arg Leu Gly Gln
        835                 840                 845             
Leu Arg Gly Phe Met Glu Thr Glu Ala Ala Ala Gln Glu Ser Leu Gly
    850                 855                 860                 
Leu Gly Lys Leu Gly Thr Gln Ala Glu Lys Asp Arg Arg Leu Lys Lys
865                 870                 875                 880 
Lys His Glu Leu Leu Glu Glu Ala Arg Arg Lys Gly Leu Pro Phe Ala
                885                 890                 895     
Gln Trp Asp Gly Pro Thr Val Val Ala Trp Leu Glu Leu Trp Leu Gly
            900                 905                 910         
Met Pro Ala Trp Tyr Val Ala Ala Cys Arg Ala Asn Val Lys Ser Gly
        915                 920                 925             
Ala Ile Met Ser Ala Leu Ser Asp Thr Glu Ile Gln Arg Glu Ile Gly
    930                 935                 940                 
Ile Ser Asn Pro Leu His Arg Leu Lys Leu Arg Leu Ala Ile Gln Glu
945                 950                 955                 960 
Met Val Ser Leu Thr Ser Pro Ser Ala Pro Pro Thr Ser Arg Thr Pro
                965                 970                 975     
Ser Gly Asn Val Trp Val Thr His Glu Glu Met Glu Asn Leu Ala Ala
            980                 985                 990         
Pro Ala Lys Thr Lys Glu Ser Glu Glu Gly Ser Trp Ala Gln Cys Pro
        995                 1000                1005            
Val Phe Leu Gln Thr Leu Ala Tyr Gly Asp Met Asn His Glu Trp Ile
    1010                1015                1020                
Gly Asn Glu Trp Leu Pro Ser Leu Gly Leu Pro Gln Tyr Arg Ser Tyr
1025                1030                1035                1040
Phe Met Glu Cys Leu Val Asp Ala Arg Met Leu Asp His Leu Thr Lys
                1045                1050                1055    
Lys Asp Leu Arg Val His Leu Lys Met Val Asp Ser Phe His Arg Thr
            1060                1065                1070        
Ser Leu Gln Tyr Gly Ile Met Cys Leu Lys Arg Leu Asn Tyr Asp Arg
        1075                1080                1085            
Lys Glu Leu Glu Arg Arg Arg Glu Ala Ser Gln His Glu Ile Lys Asp
    1090                1095                1100                
Val Leu Val Trp Ser Asn Asp Arg Val Ile Arg Trp Ile Gln Ala Ile
1105                1110                1115                1120
Gly Leu Arg Glu Tyr Ala Asn Asn Ile Leu Glu Ser Gly Val His Gly
                1125                1130                1135    
Ser Leu Ile Ala Leu Asp Glu Asn Phe Asp Tyr Ser Ser Leu Ala Leu
            1140                1145                1150        
Leu Leu Gln Ile Pro Thr Gln Asn Thr Gln Ala Arg Gln Ile Leu Glu
        1155                1160                1165            
Arg Glu Tyr Asn Asn Leu Leu Ala Leu Gly Thr Glu Arg Arg Leu Asp
    1170                1175                1180                
Glu Ser Asp Asp Lys Asn Phe Arg Arg Gly Ser Thr Trp Arg Arg Gln
1185                1190                1195                1200
Phe Pro Pro Arg Glu Val His Gly Ile Ser Met Met Pro Gly Ser Ser
                1205                1210                1215    
Glu Thr Leu Pro Ala Gly Phe Arg Leu Thr Thr Thr Ser Gly Gln Ser
            1220                1225                1230        
Arg Lys Met Thr Thr Asp Val Ala Ser Ser Arg Leu Gln Arg Leu Asp
        1235                1240                1245            
Asn Ser Thr Val Arg Thr Tyr Ser Cys
    1250                1255        


<210> 7373
<211> 1523
<212> PRT
<213> Homo sapiens

<400> 7373
Met Thr Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys Arg Ala Ala
 1               5                  10                  15      
Lys Phe Gln Phe Val Ala Cys Tyr His Glu Leu Val Leu Glu Cys Thr
            20                  25                  30          
Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Asn
        35                  40                  45              
Arg Arg Ile Cys Ser Lys Ala His Ser Trp Gln Pro Gly Ile Gln Asn
    50                  55                  60                  
Pro Tyr Arg Gly Thr Val Val Trp Met Val Pro Glu Asn Val Asp Ile
65                  70                  75                  80  
Ser Val Thr Leu Tyr Arg Asp Pro His Val Asp Gln Tyr Glu Ala Lys
                85                  90                  95      
Glu Trp Thr Phe Ile Ile Glu Asn Glu Ser Lys Gly Gln Arg Lys Val
            100                 105                 110         
Leu Ala Thr Ala Glu Val Asp Leu Ala Arg His Ala Gly Pro Val Pro
        115                 120                 125             
Val Gln Val Pro Val Arg Leu Arg Leu Lys Pro Lys Ser Val Lys Val
    130                 135                 140                 
Val Gln Ala Glu Leu Ser Leu Thr Leu Ser Gly Val Leu Leu Arg Glu
145                 150                 155                 160 
Gly Arg Ala Thr Asp Asp Asp Met Gln Ser Leu Ala Ser Leu Met Ser
                165                 170                 175     
Val Lys Pro Ser Asp Val Gly Asn Leu Asp Asp Phe Ala Glu Ser Asp
            180                 185                 190         
Glu Asp Glu Ala His Gly Pro Gly Ala Pro Glu Ala Arg Ala Arg Val
        195                 200                 205             
Pro Gln Pro Asp Pro Ser Arg Glu Leu Lys Thr Leu Cys Glu Glu Glu
    210                 215                 220                 
Glu Glu Gly Gln Gly Arg Pro Gln Gln Ala Val Ala Ser Pro Ser Asn
225                 230                 235                 240 
Ala Glu Asp Thr Ser Pro Ala Pro Val Ser Ala Pro Ala Pro Pro Ala
                245                 250                 255     
Arg Thr Ser Arg Gly Gln Gly Ser Glu Arg Ala Asn Glu Ala Gly Gly
            260                 265                 270         
Gln Val Gly Pro Glu Ala Pro Arg Pro Pro Glu Thr Ser Pro Glu Met
        275                 280                 285             
Arg Ser Ser Arg Gln Pro Ala Gln Asp Thr Ala Pro Thr Pro Ala Pro
    290                 295                 300                 
Arg Leu Arg Lys Gly Ser Asp Ala Leu Arg Pro Pro Val Pro Gln Gly
305                 310                 315                 320 
Glu Asp Glu Val Pro Lys Ala Ser Gly Ala Pro Pro Ala Gly Leu Gly
                325                 330                 335     
Ser Ala Arg Glu Thr Gln Ala Gln Ala Cys Pro Gln Glu Gly Thr Glu
            340                 345                 350         
Ala His Gly Ala Arg Leu Gly Pro Ser Ile Glu Asp Lys Gly Ser Gly
        355                 360                 365             
Asp Pro Phe Gly Arg Gln Arg Leu Lys Ala Glu Glu Met Asp Thr Glu
    370                 375                 380                 
Asp Arg Pro Glu Ala Ser Gly Val Asp Thr Glu Pro Arg Ser Gly Gly
385                 390                 395                 400 
Arg Glu Ala Asn Thr Lys Arg Ser Gly Val Arg Ala Gly Glu Ala Glu
                405                 410                 415     
Glu Ser Ser Ala Val Cys Gln Val Asp Ala Glu Gln Arg Ser Lys Val
            420                 425                 430         
Arg His Val Asp Thr Lys Gly Pro Glu Ala Thr Gly Val Met Pro Glu
        435                 440                 445             
Ala Arg Cys Arg Gly Thr Pro Glu Ala Pro Pro Arg Gly Ser Gln Gly
    450                 455                 460                 
Arg Leu Gly Val Arg Thr Arg Asp Glu Ala Pro Ser Gly Leu Ser Leu
465                 470                 475                 480 
Pro Pro Ala Glu Pro Ala Gly His Ser Gly Gln Leu Gly Asp Leu Glu
                485                 490                 495     
Gly Ala Arg Ala Ala Ala Gly Gln Glu Arg Glu Gly Ala Glu Val Arg
            500                 505                 510         
Gly Gly Ala Pro Gly Ile Glu Gly Thr Gly Leu Glu Gln Gly Pro Ser
        515                 520                 525             
Val Gly Ala Ile Ser Thr Arg Pro Gln Val Ser Ser Trp Gln Gly Ala
    530                 535                 540                 
Leu Leu Ser Thr Ala Gln Gly Ala Ile Ser Arg Gly Leu Gly Gly Trp
545                 550                 555                 560 
Glu Ala Glu Ala Gly Gly Ser Gly Asp Leu Glu Thr Glu Thr Glu Val
                565                 570                 575     
Val Gly Leu Glu Val Leu Gly Thr Gln Glu Lys Glu Val Glu Gly Ser
            580                 585                 590         
Gly Phe Pro Glu Thr Arg Thr Leu Glu Ile Glu Ile Leu Gly Ala Leu
        595                 600                 605             
Glu Lys Glu Ala Ala Arg Ser Arg Val Leu Glu Ser Glu Val Ala Gly
    610                 615                 620                 
Thr Ala Gln Cys Glu Gly Leu Glu Thr Gln Glu Thr Glu Val Gly Val
625                 630                 635                 640 
Ile Glu Thr Pro Gly Thr Glu Thr Glu Val Leu Gly Thr Gln Lys Thr
                645                 650                 655     
Glu Ala Gly Gly Ser Gly Val Leu Gln Thr Arg Thr Thr Ile Ala Glu
            660                 665                 670         
Thr Glu Val Leu Val Thr Gln Glu Ile Ser Gly Asp Leu Gly Pro Leu
        675                 680                 685             
Lys Ile Glu Asp Thr Ile Gln Ser Glu Met Leu Gly Thr Gln Glu Thr
    690                 695                 700                 
Glu Val Glu Ala Ser Arg Val Pro Glu Ser Glu Ala Glu Gly Thr Glu
705                 710                 715                 720 
Ala Lys Ile Leu Gly Thr Gln Glu Ile Thr Ala Arg Asp Ser Gly Val
                725                 730                 735     
Arg Glu Ile Glu Ala Glu Ile Ala Glu Ser Asp Ile Leu Val Ala Gln
            740                 745                 750         
Glu Ile Glu Val Gly Leu Leu Gly Val Leu Gly Ile Glu Thr Gly Ala
        755                 760                 765             
Ala Glu Gly Ala Ile Leu Gly Thr Gln Glu Ile Ala Ser Arg Asp Ser
    770                 775                 780                 
Gly Val Pro Gly Leu Glu Ala Asp Thr Thr Gly Ile Gln Val Lys Glu
785                 790                 795                 800 
Val Gly Gly Ser Glu Val Pro Glu Ile Ala Thr Gly Thr Ala Glu Thr
                805                 810                 815     
Glu Ile Leu Gly Thr Gln Glu Ile Ala Ser Arg Ser Ser Gly Val Pro
            820                 825                 830         
Gly Leu Glu Ser Glu Val Ala Gly Ala Gln Glu Thr Glu Val Gly Gly
        835                 840                 845             
Ser Gly Ile Ser Gly Pro Glu Ala Gly Met Ala Glu Ala Arg Val Leu
    850                 855                 860                 
Met Thr Arg Lys Thr Glu Ile Ile Val Pro Glu Ala Glu Lys Glu Glu
865                 870                 875                 880 
Ala Gln Thr Ser Gly Val Gln Glu Ala Glu Thr Arg Val Gly Ser Ala
                885                 890                 895     
Leu Lys Tyr Glu Ala Leu Arg Ala Pro Val Thr Gln Pro Arg Val Leu
            900                 905                 910         
Gly Ser Gln Glu Ala Lys Ala Glu Ile Ser Gly Val Gln Gly Ser Glu
        915                 920                 925             
Thr Gln Val Leu Arg Val Gln Glu Ala Glu Ala Gly Val Trp Gly Met
    930                 935                 940                 
Ser Glu Gly Lys Ser Gly Ala Trp Gly Ala Gln Glu Ala Glu Met Lys
945                 950                 955                 960 
Val Leu Glu Ser Pro Glu Asn Lys Ser Gly Thr Phe Lys Ala Gln Glu
                965                 970                 975     
Ala Glu Ala Gly Val Leu Gly Asn Glu Lys Gly Lys Glu Ala Glu Gly
            980                 985                 990         
Ser Leu Thr Glu Ala Ser Leu Pro Glu Ala Gln Val Ala Ser Gly Ala
        995                 1000                1005            
Gly Ala Gly Ala Pro Arg Ala Ser Ser Pro Glu Lys Ala Glu Glu Asp
    1010                1015                1020                
Arg Arg Leu Pro Gly Ser Gln Ala Pro Pro Ala Leu Val Ser Ser Ser
1025                1030                1035                1040
Gln Ser Leu Leu Glu Trp Cys Gln Glu Val Thr Thr Gly Tyr Arg Gly
                1045                1050                1055    
Val Arg Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly Leu Ala Phe
            1060                1065                1070        
Cys Ala Ile Leu His Arg Phe Tyr Pro Asp Lys Ile Asp Tyr Ala Ser
        1075                1080                1085            
Leu Asp Pro Leu Asn Ile Lys Gln Asn Asn Lys Gln Ala Phe Asp Gly
    1090                1095                1100                
Phe Ala Ala Leu Gly Val Ser Arg Leu Leu Glu Pro Ala Asp Met Val
1105                1110                1115                1120
Leu Leu Ser Val Pro Asp Lys Leu Ile Val Met Thr Tyr Leu Cys Gln
                1125                1130                1135    
Ile Arg Ala Phe Cys Thr Gly Gln Glu Leu Gln Leu Val Gln Leu Glu
            1140                1145                1150        
Gly Gly Gly Gly Ala Gly Thr Tyr Arg Val Gly Ser Ala Gln Pro Ser
        1155                1160                1165            
Pro Pro Asp Asp Leu Asp Ala Gly Gly Leu Ala Gln Arg Leu Arg Gly
    1170                1175                1180                
His Gly Ala Glu Gly Pro Gln Glu Pro Lys Glu Ala Ala Asp Arg Ala
1185                1190                1195                1200
Asp Gly Ala Ala Pro Gly Val Ala Ser Arg Asn Ala Val Ala Gly Arg
                1205                1210                1215    
Ala Ser Lys Asp Gly Gly Ala Glu Ala Pro Arg Glu Ser Arg Pro Ala
            1220                1225                1230        
Glu Val Pro Ala Glu Gly Leu Val Asn Gly Ala Gly Ala Pro Gly Gly
        1235                1240                1245            
Gly Gly Val Arg Leu Arg Arg Pro Ser Val Asn Gly Glu Pro Gly Ser
    1250                1255                1260                
Val Pro Pro Pro Arg Ala His Gly Ser Phe Ser His Val Arg Asp Ala
1265                1270                1275                1280
Asp Leu Leu Lys Lys Arg Arg Ser Arg Leu Arg Asn Ser Ser Ser Phe
                1285                1290                1295    
Ser Met Asp Asp Pro Asp Ala Gly Ala Met Gly Ala Ala Ala Ala Glu
            1300                1305                1310        
Gly Gln Ala Pro Asp Pro Ser Pro Ala Pro Gly Pro Pro Thr Ala Ala
        1315                1320                1325            
Asp Ser Gln Gln Pro Pro Gly Gly Ser Ser Pro Ser Glu Glu Pro Pro
    1330                1335                1340                
Pro Ser Pro Gly Glu Glu Ala Gly Leu Gln Arg Phe Gln Asp Thr Ser
1345                1350                1355                1360
Gln Tyr Val Cys Ala Glu Leu Gln Ala Leu Glu Gln Glu Gln Arg Gln
                1365                1370                1375    
Ile Asp Gly Arg Ala Ala Glu Val Glu Met Gln Leu Arg Ser Leu Met
            1380                1385                1390        
Glu Ser Gly Ala Asn Lys Leu Gln Glu Glu Val Leu Ile Gln Glu Trp
        1395                1400                1405            
Phe Thr Leu Val Asn Lys Lys Asn Ala Leu Ile Arg Arg Gln Asp Gln
    1410                1415                1420                
Leu Gln Leu Leu Met Glu Glu Gln Asp Leu Glu Arg Arg Phe Glu Leu
1425                1430                1435                1440
Leu Ser Arg Glu Leu Arg Ala Met Leu Ala Ile Glu Asp Trp Gln Lys
                1445                1450                1455    
Thr Ser Ala Gln Gln His Arg Glu Gln Leu Leu Leu Glu Glu Leu Val
            1460                1465                1470        
Ser Leu Val Asn Gln Arg Asp Glu Leu Val Arg Asp Leu Asp His Lys
        1475                1480                1485            
Glu Arg Ile Ala Leu Glu Glu Asp Glu Arg Leu Glu Arg Gly Leu Glu
    1490                1495                1500                
Gln Arg Arg Arg Lys Leu Ser Arg Gln Leu Ser Arg Arg Glu Arg Cys
1505                1510                1515                1520
Val Leu Ser
            


<210> 7374
<211> 611
<212> PRT
<213> Homo sapiens

<400> 7374
Met Ala Glu Glu Thr Gly Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys
 1               5                  10                  15      
Phe Lys Glu Tyr Trp Gln Arg Asn Arg Pro Gly Val Pro Ala Ala Ala
            20                  25                  30          
Lys Arg Asn Thr Lys Ala Asn Gly Ser Ser Pro Glu Thr Ala Ala Ser
        35                  40                  45              
Gly Gly Cys His Ser Ser Glu Ala Ser Ser Ser Ala Ser Ser Ser Leu
    50                  55                  60                  
His Ala Arg Gln Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser
65                  70                  75                  80  
Arg Ser Ile Lys Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys
                85                  90                  95      
Gln Gln Lys Lys Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala
            100                 105                 110         
Asn Asn Glu Lys Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln
        115                 120                 125             
Arg Leu Asn Thr Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met
    130                 135                 140                 
Lys His Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly
145                 150                 155                 160 
Arg Leu Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu
                165                 170                 175     
Cys Ala Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser
            180                 185                 190         
Arg Ser Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu
        195                 200                 205             
Gln Ile Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys
    210                 215                 220                 
Glu Val Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu
225                 230                 235                 240 
Arg Ala Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys
                245                 250                 255     
Thr Leu Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu
            260                 265                 270         
Glu Arg Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro
        275                 280                 285             
Pro Asp Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg
    290                 295                 300                 
Lys Glu Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn
305                 310                 315                 320 
Asn Gln Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg
                325                 330                 335     
Glu Gln Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Arg
            340                 345                 350         
Glu Lys Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu
        355                 360                 365             
Leu Lys His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys
    370                 375                 380                 
Glu Leu Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala
385                 390                 395                 400 
Glu Lys Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu
                405                 410                 415     
Ser Ser Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu
            420                 425                 430         
His Val Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg
        435                 440                 445             
Cys His Gln Lys Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala
    450                 455                 460                 
Lys Asp Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln
465                 470                 475                 480 
Gly Gly Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala
                485                 490                 495     
Ala Cys Gly Ser Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala Ala
            500                 505                 510         
Arg Asn Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu
        515                 520                 525             
Leu Gly Ala Ala Asp Lys His Gly Asp Pro Arg Leu Pro Leu Ser Lys
    530                 535                 540                 
Asp Leu Cys Glu Ala Ser Leu Thr Asn Ser Val Glu Pro Ala Gln Gly
545                 550                 555                 560 
Glu Ala Arg Glu Gly Ser Ser Gln Asp Asn Pro Thr Ala Gln Pro Val
                565                 570                 575     
Val Gln Leu Leu Gly Glu Met Gln Asp His Gln Glu His Pro Gly Leu
            580                 585                 590         
Gly Ser Asn Cys Cys Val Pro Cys Phe Cys Trp Ala Trp Leu Pro Arg
        595                 600                 605             
Arg Arg Arg
    610     


<210> 7375
<211> 468
<212> PRT
<213> Homo sapiens

<400> 7375
Met Lys His Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala
 1               5                  10                  15      
Gly Arg Leu Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser
            20                  25                  30          
Leu Cys Ala Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser
        35                  40                  45              
Ser Arg Ser Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg
    50                  55                  60                  
Glu Gln Ile Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu
65                  70                  75                  80  
Lys Glu Val Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly
                85                  90                  95      
Glu Arg Ala Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val
            100                 105                 110         
Cys Thr Leu Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu
        115                 120                 125             
Leu Glu Arg Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu
    130                 135                 140                 
Pro Pro Asp Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu
145                 150                 155                 160 
Arg Lys Glu Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu
                165                 170                 175     
Asn Asn Gln Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu
            180                 185                 190         
Arg Glu Gln Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu
        195                 200                 205             
Arg Glu Lys Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu
    210                 215                 220                 
Glu Leu Lys His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val
225                 230                 235                 240 
Lys Glu Leu Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser
                245                 250                 255     
Ala Glu Lys Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly
            260                 265                 270         
Glu Ser Ser Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg
        275                 280                 285             
Glu His Val Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu
    290                 295                 300                 
Arg Cys His Gln Lys Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser
305                 310                 315                 320 
Ala Lys Asp Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly
                325                 330                 335     
Gln Gly Gly Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val
            340                 345                 350         
Ala Ala Cys Gly Ser Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala
        355                 360                 365             
Ala Arg Asn Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln
    370                 375                 380                 
Glu Leu Gly Ala Ala Asp Lys His Gly Asp Pro Arg Leu Pro Leu Ser
385                 390                 395                 400 
Lys Asp Leu Cys Glu Ala Ser Leu Thr Asn Ser Val Glu Pro Ala Gln
                405                 410                 415     
Gly Glu Ala Arg Glu Gly Ser Ser Gln Asp Asn Pro Thr Ala Gln Pro
            420                 425                 430         
Val Val Gln Leu Leu Gly Glu Met Gln Asp His Gln Glu His Pro Gly
        435                 440                 445             
Leu Gly Ser Asn Cys Cys Val Pro Cys Phe Cys Trp Ala Trp Leu Pro
    450                 455                 460                 
Arg Arg Arg Arg
465             


<210> 7376
<211> 468
<212> PRT
<213> Homo sapiens

<400> 7376
Met Lys His Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala
 1               5                  10                  15      
Gly Arg Leu Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser
            20                  25                  30          
Leu Cys Ala Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser
        35                  40                  45              
Ser Arg Ser Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg
    50                  55                  60                  
Glu Gln Ile Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu
65                  70                  75                  80  
Lys Glu Val Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly
                85                  90                  95      
Glu Arg Ala Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val
            100                 105                 110         
Cys Thr Leu Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu
        115                 120                 125             
Leu Glu Arg Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu
    130                 135                 140                 
Pro Pro Asp Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu
145                 150                 155                 160 
Arg Lys Glu Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu
                165                 170                 175     
Asn Asn Gln Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu
            180                 185                 190         
Arg Glu Gln Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu
        195                 200                 205             
Arg Glu Lys Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu
    210                 215                 220                 
Glu Leu Lys His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val
225                 230                 235                 240 
Lys Glu Leu Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser
                245                 250                 255     
Ala Glu Lys Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly
            260                 265                 270         
Glu Ser Ser Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg
        275                 280                 285             
Glu His Val Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu
    290                 295                 300                 
Arg Cys His Gln Lys Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser
305                 310                 315                 320 
Ala Lys Asp Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly
                325                 330                 335     
Gln Gly Gly Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val
            340                 345                 350         
Ala Ala Cys Gly Ser Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala
        355                 360                 365             
Ala Arg Asn Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln
    370                 375                 380                 
Glu Leu Gly Ala Ala Asp Lys His Gly Asp Pro Arg Leu Ser Leu Ser
385                 390                 395                 400 
Lys Asp Leu Cys Glu Ala Ser Leu Thr Asn Ser Val Glu Pro Ala Gln
                405                 410                 415     
Gly Glu Ala Arg Glu Gly Ser Ser Gln Asp Asn Pro Thr Ala Gln Pro
            420                 425                 430         
Val Leu Gln Leu Leu Gly Glu Met Gln Asp His Gln Glu His Pro Gly
        435                 440                 445             
Leu Gly Ser Asn Cys Cys Val Pro Cys Phe Cys Trp Ala Trp Leu Pro
    450                 455                 460                 
Arg Arg Arg Arg
465             


<210> 7377
<211> 603
<212> PRT
<213> Homo sapiens

<400> 7377
Met Ala Glu Glu Thr Gly Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys
 1               5                  10                  15      
Phe Lys Glu Tyr Trp Gln Arg Asn Arg Pro Gly Val Pro Ala Ala Ala
            20                  25                  30          
Lys Arg Asn Thr Lys Ala Asn Gly Ser Ser Pro Glu Thr Ala Ala Ser
        35                  40                  45              
Gly Gly Cys His Ser Ser Glu Ala Ser Ser Ser Ala Ser Ser Ser Leu
    50                  55                  60                  
His Ala Arg Gln Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser
65                  70                  75                  80  
Arg Ser Ile Lys Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys
                85                  90                  95      
Gln Gln Lys Lys Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala
            100                 105                 110         
Asn Asn Glu Lys Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln
        115                 120                 125             
Arg Leu Asn Thr Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met
    130                 135                 140                 
Lys His Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly
145                 150                 155                 160 
Arg Leu Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu
                165                 170                 175     
Cys Ala Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser
            180                 185                 190         
Arg Ser Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu
        195                 200                 205             
Gln Ile Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys
    210                 215                 220                 
Glu Val Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu
225                 230                 235                 240 
Arg Ala Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys
                245                 250                 255     
Thr Leu Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu
            260                 265                 270         
Glu Arg Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro
        275                 280                 285             
Pro Asp Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg
    290                 295                 300                 
Lys Glu Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn
305                 310                 315                 320 
Asn Gln Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg
                325                 330                 335     
Glu Gln Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Arg
            340                 345                 350         
Glu Lys Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu
        355                 360                 365             
Leu Lys His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys
    370                 375                 380                 
Glu Leu Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala
385                 390                 395                 400 
Glu Lys Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu
                405                 410                 415     
Ser Ser Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu
            420                 425                 430         
His Val Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg
        435                 440                 445             
Cys His Gln Lys Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala
    450                 455                 460                 
Lys Asp Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln
465                 470                 475                 480 
Gly Gly Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala
                485                 490                 495     
Ala Cys Gly Ser Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala Ala
            500                 505                 510         
Arg Asn Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu
        515                 520                 525             
Leu Gly Ala Ala Asp Lys His Gly Asp Leu Cys Glu Ala Ser Leu Thr
    530                 535                 540                 
Asn Ser Val Glu Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Ser Gln
545                 550                 555                 560 
Asp Asn Pro Thr Ala Gln Pro Val Leu Gln Leu Leu Gly Glu Met Gln
                565                 570                 575     
Asp His Gln Glu His Pro Gly Leu Gly Ser Asn Cys Cys Val Pro Cys
            580                 585                 590         
Phe Cys Trp Ala Trp Leu Pro Arg Arg Arg Arg
        595                 600             


<210> 7378
<211> 631
<212> PRT
<213> Homo sapiens

<400> 7378
Met Leu Pro Val Asp Gly Glu Glu Arg Lys Ser Glu Gly Ser Asp Thr
 1               5                  10                  15      
Glu Gly Asp Arg Thr Ser Pro Cys Ala Val Ser Ser Ala Thr Leu Lys
            20                  25                  30          
Asp Leu Glu Val Gly Gly Ser Gly Arg Arg Cys Ser Asp Pro Ala Gly
        35                  40                  45              
Gln Pro Ser Asn Leu Leu Pro Gln Arg Gly Leu Gly Ala Pro Leu Pro
    50                  55                  60                  
Ala Glu Thr Ala His Thr Gln Pro Ser Pro Asn Asp Arg Ser Leu Tyr
65                  70                  75                  80  
Leu Ser Pro Lys Ser Ser Ser Ala Ser Ser Ser Leu His Ala Arg Gln
                85                  90                  95      
Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser Arg Ser Ile Lys
            100                 105                 110         
Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys Gln Gln Lys Lys
        115                 120                 125             
Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala Asn Asn Glu Lys
    130                 135                 140                 
Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln Arg Leu Asn Thr
145                 150                 155                 160 
Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met Lys His Ser Leu
                165                 170                 175     
Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly Arg Leu Gln Arg
            180                 185                 190         
Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu Cys Ala Val Ala
        195                 200                 205             
Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser Arg Ser Lys Ala
    210                 215                 220                 
Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu Gln Ile Leu Leu
225                 230                 235                 240 
Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys Glu Val Gln Leu
                245                 250                 255     
Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu Arg Ala Gln Trp
            260                 265                 270         
Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys Thr Leu Lys Glu
        275                 280                 285             
Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu Glu Arg Ser Leu
    290                 295                 300                 
Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro Pro Asp Ala Pro
305                 310                 315                 320 
Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg Lys Glu Leu Glu
                325                 330                 335     
Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn Asn Gln Cys Ile
            340                 345                 350         
Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg Glu Gln Glu Glu
        355                 360                 365             
Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Arg Glu Lys Arg Leu
    370                 375                 380                 
Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu Leu Lys His Glu
385                 390                 395                 400 
Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys Glu Leu Gln Glu
                405                 410                 415     
Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala Glu Lys Glu Pro
            420                 425                 430         
Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu Ser Ser Gly Leu
        435                 440                 445             
Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu His Val Glu Lys
    450                 455                 460                 
Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg Cys His Gln Lys
465                 470                 475                 480 
Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala Lys Asp Ala Ser
                485                 490                 495     
Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln Gly Gly Glu Glu
            500                 505                 510         
Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala Ala Cys Gly Ser
        515                 520                 525             
Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala Ala Arg Asn Pro Ala
    530                 535                 540                 
Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu Leu Gly Ala Ala
545                 550                 555                 560 
Asp Lys His Gly Asp Leu Cys Glu Ala Ser Leu Thr Asn Ser Val Glu
                565                 570                 575     
Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Ser Gln Asp Asn Pro Thr
            580                 585                 590         
Ala Gln Pro Val Val Gln Leu Leu Gly Glu Met Gln Asp His Gln Glu
        595                 600                 605             
His Pro Gly Leu Gly Ser Asn Cys Cys Val Pro Cys Phe Cys Trp Ala
    610                 615                 620                 
Trp Leu Pro Arg Arg Arg Arg
625                 630     


<210> 7379
<211> 603
<212> PRT
<213> Homo sapiens

<400> 7379
Met Ala Glu Glu Thr Gly Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys
 1               5                  10                  15      
Phe Lys Glu Tyr Trp Gln Arg Asn Arg Pro Gly Val Pro Ala Ala Ala
            20                  25                  30          
Lys Arg Asn Thr Lys Ala Asn Gly Ser Ser Pro Glu Thr Ala Ala Ser
        35                  40                  45              
Gly Gly Cys His Ser Ser Glu Ala Ser Ser Ser Ala Ser Ser Ser Leu
    50                  55                  60                  
His Ala Arg Gln Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser
65                  70                  75                  80  
Arg Ser Ile Lys Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys
                85                  90                  95      
Gln Gln Lys Lys Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala
            100                 105                 110         
Asn Asn Glu Lys Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln
        115                 120                 125             
Arg Leu Asn Thr Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met
    130                 135                 140                 
Lys His Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly
145                 150                 155                 160 
Arg Leu Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu
                165                 170                 175     
Cys Ala Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser
            180                 185                 190         
Arg Ser Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu
        195                 200                 205             
Gln Ile Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys
    210                 215                 220                 
Glu Val Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu
225                 230                 235                 240 
Arg Ala Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys
                245                 250                 255     
Thr Leu Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu
            260                 265                 270         
Glu Arg Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro
        275                 280                 285             
Pro Asp Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg
    290                 295                 300                 
Lys Glu Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn
305                 310                 315                 320 
Asn Gln Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg
                325                 330                 335     
Glu Gln Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Arg
            340                 345                 350         
Glu Lys Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu
        355                 360                 365             
Leu Lys His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys
    370                 375                 380                 
Glu Leu Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala
385                 390                 395                 400 
Glu Lys Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu
                405                 410                 415     
Ser Ser Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu
            420                 425                 430         
His Val Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg
        435                 440                 445             
Cys His Gln Lys Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala
    450                 455                 460                 
Lys Asp Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln
465                 470                 475                 480 
Gly Gly Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala
                485                 490                 495     
Ala Cys Gly Ser Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala Ala
            500                 505                 510         
Arg Asn Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu
        515                 520                 525             
Leu Gly Ala Ala Asp Lys His Gly Asp Leu Cys Glu Ala Ser Leu Thr
    530                 535                 540                 
Asn Ser Val Glu Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Ser Gln
545                 550                 555                 560 
Asp Asn Pro Thr Ala Gln Pro Val Val Gln Leu Leu Gly Glu Met Gln
                565                 570                 575     
Asp His Gln Glu His Pro Gly Leu Gly Ser Asn Cys Cys Val Pro Cys
            580                 585                 590         
Phe Cys Trp Ala Trp Leu Pro Arg Arg Arg Arg
        595                 600             


<210> 7380
<211> 1300
<212> PRT
<213> Homo sapiens

<400> 7380
Lys Asn Leu Glu Gly Asn His Asp Gln His Gly Arg Asn Ser Leu Leu
 1               5                  10                  15      
Ala Ser Tyr Ile His Tyr Val Phe Arg Leu Pro Asn Thr Tyr Pro Asn
            20                  25                  30          
Ser Ser Ser Pro Gly Pro Gly Gly Leu Gly Gly Ser Val His Tyr Ala
        35                  40                  45              
Thr Met Ala Arg Ser Ala Val Arg Pro Ala Ser Leu Asn Leu Asn Arg
    50                  55                  60                  
Ser Arg Ser Leu Ser Asn Ser Asn Pro Asp Ile Ser Gly Thr Pro Thr
65                  70                  75                  80  
Ser Pro Asp Asp Glu Val Arg Ser Ile Ile Gly Ser Lys Gly Leu Asp
                85                  90                  95      
Arg Ser Asn Ser Trp Val Asn Thr Gly Gly Pro Lys Ala Ala Pro Trp
            100                 105                 110         
Gly Ser Asn Pro Ser Pro Ser Ala Glu Ser Thr Gln Ala Met Asp Arg
        115                 120                 125             
Ser Cys Asn Arg Met Ser Ser His Thr Glu Thr Ser Ser Phe Leu Gln
    130                 135                 140                 
Thr Leu Thr Gly Arg Leu Pro Thr Lys Lys Leu Phe His Glu Glu Leu
145                 150                 155                 160 
Ala Leu Gln Trp Val Val Cys Ser Gly Ser Val Arg Glu Ser Ala Leu
                165                 170                 175     
Gln Gln Ala Trp Phe Phe Phe Glu Leu Met Val Lys Ser Met Val His
            180                 185                 190         
His Leu Tyr Phe Asn Asp Lys Leu Glu Ala Pro Arg Lys Ser Arg Phe
        195                 200                 205             
Pro Glu Arg Phe Met Asp Asp Ile Ala Ala Leu Val Ser Thr Ile Ala
    210                 215                 220                 
Ser Asp Ile Val Ser Arg Phe Gln Lys Asp Thr Glu Met Val Glu Arg
225                 230                 235                 240 
Leu Asn Thr Ser Leu Ala Phe Phe Leu Asn Asp Leu Leu Ser Val Met
                245                 250                 255     
Asp Arg Gly Phe Val Phe Ser Leu Ile Lys Ser Cys Tyr Lys Gln Val
            260                 265                 270         
Ser Ser Lys Leu Tyr Ser Leu Pro Asn Pro Ser Val Leu Val Ser Leu
        275                 280                 285             
Arg Leu Asp Phe Leu Arg Ile Ile Cys Ser His Glu His Tyr Val Thr
    290                 295                 300                 
Leu Asn Leu Pro Cys Ser Leu Leu Thr Pro Pro Ala Ser Pro Ser Pro
305                 310                 315                 320 
Ser Val Ser Ser Ala Thr Ser Gln Ser Ser Gly Phe Ser Thr Asn Val
                325                 330                 335     
Gln Asp Gln Lys Ile Ala Asn Met Phe Glu Leu Ser Val Pro Phe Arg
            340                 345                 350         
Gln Gln His Tyr Leu Ala Gly Leu Val Leu Thr Glu Leu Ala Val Ile
        355                 360                 365             
Leu Asp Pro Asp Ala Glu Gly Leu Phe Gly Leu His Lys Lys Val Ile
    370                 375                 380                 
Asn Met Val His Asn Leu Leu Ser Ser His Asp Ser Asp Pro Arg Tyr
385                 390                 395                 400 
Ser Asp Pro Gln Ile Lys Ala Arg Val Ala Met Leu Tyr Leu Pro Leu
                405                 410                 415     
Ile Gly Ile Ile Met Glu Thr Val Pro Gln Leu Tyr Asp Phe Thr Glu
            420                 425                 430         
Thr His Asn Gln Arg Gly Arg Pro Ile Cys Ile Ala Thr Asp Asp Tyr
        435                 440                 445             
Glu Ser Glu Ser Gly Ser Met Ile Ser Gln Thr Val Ala Met Ala Ile
    450                 455                 460                 
Ala Gly Thr Ser Val Pro Gln Leu Thr Arg Pro Gly Ser Phe Leu Leu
465                 470                 475                 480 
Thr Ser Thr Ser Gly Arg Gln His Thr Thr Phe Ser Ala Glu Ser Ser
                485                 490                 495     
Arg Ser Leu Leu Ile Cys Leu Leu Trp Val Leu Lys Asn Ala Asp Glu
            500                 505                 510         
Thr Val Leu Gln Lys Trp Phe Thr Asp Leu Ser Val Leu Gln Leu Asn
        515                 520                 525             
Arg Leu Leu Asp Leu Leu Tyr Leu Cys Val Ser Cys Phe Glu Tyr Lys
    530                 535                 540                 
Gly Lys Lys Val Phe Glu Arg Met Asn Ser Leu Thr Phe Lys Lys Ser
545                 550                 555                 560 
Lys Asp Met Arg Ala Lys Leu Glu Glu Ala Ile Leu Gly Ser Ile Gly
                565                 570                 575     
Ala Arg Gln Glu Met Val Arg Arg Ser Arg Gly Gln Leu Glu Arg Ser
            580                 585                 590         
Pro Ser Gly Ser Ala Phe Gly Ser Gln Glu Asn Leu Arg Trp Arg Lys
        595                 600                 605             
Asp Met Thr His Trp Arg Gln Asn Thr Glu Lys Leu Asp Lys Ser Arg
    610                 615                 620                 
Ala Glu Ile Glu His Glu Ala Leu Ile Asp Gly Asn Leu Ala Thr Glu
625                 630                 635                 640 
Ala Asn Leu Ile Ile Leu Asp Thr Leu Glu Ile Val Val Gln Thr Val
                645                 650                 655     
Ser Val Thr Glu Ser Lys Glu Ser Ile Leu Gly Gly Val Leu Lys Val
            660                 665                 670         
Leu Leu His Ser Met Ala Cys Asn Gln Ser Ala Val Tyr Leu Gln His
        675                 680                 685             
Cys Phe Ala Thr Gln Arg Ala Leu Val Ser Lys Phe Pro Glu Leu Leu
    690                 695                 700                 
Phe Glu Glu Glu Thr Glu Gln Cys Ala Asp Leu Cys Leu Arg Leu Leu
705                 710                 715                 720 
Arg His Cys Ser Ser Ser Ile Gly Thr Ile Arg Ser His Ala Ser Ala
                725                 730                 735     
Ser Leu Tyr Leu Leu Met Arg Gln Asn Phe Glu Ile Gly Asn Asn Phe
            740                 745                 750         
Ala Arg Val Lys Met Gln Val Thr Met Ser Leu Ser Ser Leu Val Gly
        755                 760                 765             
Thr Ser Gln Asn Phe Asn Glu Glu Phe Leu Arg Arg Ser Leu Lys Thr
    770                 775                 780                 
Ile Leu Thr Tyr Ala Glu Glu Asp Leu Glu Leu Arg Glu Thr Thr Phe
785                 790                 795                 800 
Pro Asp Gln Val Gln Asp Leu Val Phe Asn Leu His Met Ile Leu Ser
                805                 810                 815     
Asp Thr Val Lys Met Lys Glu His Gln Glu Asp Pro Glu Met Leu Ile
            820                 825                 830         
Asp Leu Met Tyr Arg Ile Ala Lys Gly Tyr Gln Thr Ser Pro Asp Leu
        835                 840                 845             
Arg Leu Thr Trp Leu Gln Asn Met Ala Gly Lys His Ser Glu Arg Ser
    850                 855                 860                 
Asn His Ala Glu Ala Ala Gln Cys Leu Val His Ser Ala Ala Leu Val
865                 870                 875                 880 
Ala Glu Tyr Leu Ser Met Leu Glu Asp Arg Lys Tyr Leu Pro Val Gly
                885                 890                 895     
Cys Val Thr Phe Gln Asn Ile Ser Ser Asn Val Leu Glu Glu Ser Ala
            900                 905                 910         
Val Ser Asp Asp Val Val Ser Pro Asp Glu Glu Gly Ile Cys Ser Gly
        915                 920                 925             
Lys Tyr Phe Thr Glu Ser Gly Leu Val Gly Leu Leu Glu Gln Ala Ala
    930                 935                 940                 
Ala Ser Phe Ser Met Ala Gly Met Tyr Glu Ala Val Asn Glu Val Tyr
945                 950                 955                 960 
Lys Val Leu Ile Pro Ile His Glu Ala Asn Arg Asp Ala Lys Lys Leu
                965                 970                 975     
Ser Thr Ile His Gly Lys Leu Gln Glu Ala Phe Ser Lys Ile Val His
            980                 985                 990         
Gln Asp Gly Lys Arg Met Phe Gly Thr Tyr Phe Arg Val Gly Phe Tyr
        995                 1000                1005            
Gly Thr Lys Phe Gly Asp Leu Asp Glu Gln Glu Phe Val Tyr Lys Glu
    1010                1015                1020                
Pro Ala Ile Thr Lys Leu Ala Glu Ile Ser His Arg Leu Glu Gly Phe
1025                1030                1035                1040
Tyr Gly Glu Arg Phe Gly Glu Asp Val Val Glu Val Ile Lys Asp Ser
                1045                1050                1055    
Asn Pro Val Asp Lys Cys Lys Leu Asp Pro Asn Lys Ala Tyr Ile Gln
            1060                1065                1070        
Ile Thr Tyr Val Glu Pro Tyr Phe Asp Thr Tyr Glu Met Lys Asp Arg
        1075                1080                1085            
Ile Thr Tyr Phe Asp Lys Asn Tyr Asn Leu Arg Arg Phe Met Tyr Cys
    1090                1095                1100                
Thr Pro Phe Thr Leu Asp Gly Arg Ala His Gly Glu Leu His Glu Gln
1105                1110                1115                1120
Phe Lys Arg Lys Thr Ile Leu Thr Thr Ser His Ala Phe Pro Tyr Ile
                1125                1130                1135    
Lys Thr Arg Val Asn Val Thr His Lys Glu Glu Ile Ile Leu Thr Pro
            1140                1145                1150        
Ile Glu Val Ala Ile Glu Asp Met Gln Lys Lys Thr Gln Glu Leu Ala
        1155                1160                1165            
Phe Ala Thr His Gln Asp Pro Ala Asp Pro Lys Met Leu Gln Met Val
    1170                1175                1180                
Leu Gln Gly Ser Val Gly Thr Thr Val Asn Gln Gly Pro Leu Glu Val
1185                1190                1195                1200
Ala Gln Val Phe Leu Ser Glu Ile Pro Ser Asp Pro Lys Leu Phe Arg
                1205                1210                1215    
His His Asn Lys Leu Arg Leu Cys Phe Lys Asp Phe Thr Lys Arg Cys
            1220                1225                1230        
Glu Asp Ala Leu Arg Lys Asn Lys Ser Leu Ile Gly Pro Asp Gln Lys
        1235                1240                1245            
Glu Tyr Gln Arg Glu Leu Glu Arg Asn Tyr His Arg Leu Lys Glu Ala
    1250                1255                1260                
Leu Gln Pro Leu Ile Asn Arg Lys Ile Pro Gln Leu Tyr Lys Ala Val
1265                1270                1275                1280
Leu Pro Val Thr Cys His Arg Asp Ser Phe Ser Arg Met Ser Leu Arg
                1285                1290                1295    
Lys Met Asp Leu
            1300


<210> 7381
<211> 1302
<212> PRT
<213> Homo sapiens

<400> 7381
Lys Asn Leu Glu Gly Asn His Asp Gln His Gly Arg Asn Ser Leu Leu
 1               5                  10                  15      
Ala Ser Tyr Ile His Tyr Val Phe Arg Leu Pro Asn Thr Tyr Pro Asn
            20                  25                  30          
Ser Ser Ser Pro Gly Pro Gly Gly Leu Gly Gly Ser Val His Tyr Ala
        35                  40                  45              
Thr Met Ala Arg Ser Ala Val Arg Pro Ala Ser Leu Asn Leu Asn Arg
    50                  55                  60                  
Ser Arg Ser Leu Ser Asn Ser Asn Pro Asp Ile Ser Gly Thr Pro Thr
65                  70                  75                  80  
Ser Pro Asp Asp Glu Val Arg Ser Ile Ile Gly Ser Lys Gly Leu Asp
                85                  90                  95      
Arg Ser Asn Ser Trp Val Asn Thr Gly Gly Pro Lys Ala Ala Pro Trp
            100                 105                 110         
Gly Ser Asn Pro Ser Pro Ser Ala Glu Ser Thr Gln Ala Met Asp Arg
        115                 120                 125             
Ser Cys Asn Arg Met Ser Ser His Thr Glu Thr Ser Ser Phe Leu Gln
    130                 135                 140                 
Thr Leu Thr Gly Arg Leu Pro Thr Lys Lys Leu Phe His Glu Glu Leu
145                 150                 155                 160 
Ala Leu Gln Trp Val Val Cys Ser Gly Ser Val Arg Glu Ser Ala Leu
                165                 170                 175     
Gln Gln Ala Trp Phe Phe Phe Glu Leu Met Val Lys Ser Met Val His
            180                 185                 190         
His Leu Tyr Phe Asn Asp Lys Leu Glu Ala Pro Arg Lys Ser Arg Phe
        195                 200                 205             
Pro Glu Arg Phe Met Asp Asp Ile Ala Ala Leu Val Ser Thr Ile Ala
    210                 215                 220                 
Ser Asp Ile Val Ser Arg Phe Gln Lys Asp Thr Glu Met Val Glu Arg
225                 230                 235                 240 
Leu Asn Thr Ser Leu Ala Phe Phe Leu Asn Asp Leu Leu Ser Val Met
                245                 250                 255     
Asp Arg Gly Phe Val Phe Ser Leu Ile Lys Ser Cys Tyr Lys Gln Val
            260                 265                 270         
Ser Ser Lys Leu Tyr Ser Leu Pro Asn Pro Ser Val Leu Val Ser Leu
        275                 280                 285             
Arg Leu Asp Phe Leu Arg Ile Ile Cys Ser His Glu His Tyr Val Thr
    290                 295                 300                 
Leu Asn Leu Pro Cys Ser Leu Leu Thr Pro Pro Ala Ser Pro Ser Pro
305                 310                 315                 320 
Ser Val Ser Ser Ala Thr Ser Gln Ser Ser Gly Phe Ser Thr Asn Val
                325                 330                 335     
Gln Asp Gln Lys Ile Ala Asn Met Phe Glu Leu Ser Val Pro Phe Arg
            340                 345                 350         
Gln Gln His Tyr Leu Ala Gly Leu Val Leu Thr Glu Leu Ala Val Ile
        355                 360                 365             
Leu Asp Pro Asp Ala Glu Gly Leu Phe Gly Leu His Lys Lys Val Ile
    370                 375                 380                 
Asn Met Val His Asn Leu Leu Ser Ser His Asp Ser Asp Pro Arg Tyr
385                 390                 395                 400 
Ser Asp Pro Gln Ile Lys Ala Arg Val Ala Met Leu Tyr Leu Pro Leu
                405                 410                 415     
Ile Gly Ile Ile Met Glu Thr Val Pro Gln Leu Tyr Asp Phe Thr Glu
            420                 425                 430         
Thr His Asn Gln Arg Gly Arg Pro Ile Cys Ile Ala Thr Asp Asp Tyr
        435                 440                 445             
Glu Ser Glu Ser Gly Ser Met Ile Ser Gln Thr Val Ala Met Ala Ile
    450                 455                 460                 
Ala Gly Thr Ser Val Pro Gln Leu Thr Arg Pro Gly Ser Phe Leu Leu
465                 470                 475                 480 
Thr Ser Thr Ser Gly Arg Gln His Thr Thr Phe Ser Ala Glu Ser Ser
                485                 490                 495     
Arg Ser Leu Leu Ile Cys Leu Leu Trp Val Leu Lys Asn Ala Asp Glu
            500                 505                 510         
Thr Val Leu Gln Lys Trp Phe Thr Asp Leu Ser Val Leu Gln Leu Asn
        515                 520                 525             
Arg Leu Leu Asp Leu Leu Tyr Leu Cys Val Ser Cys Phe Glu Tyr Lys
    530                 535                 540                 
Gly Lys Lys Val Phe Glu Arg Met Asn Ser Leu Thr Phe Lys Lys Ser
545                 550                 555                 560 
Lys Asp Met Arg Ala Lys Leu Glu Glu Ala Ile Leu Gly Ser Ile Gly
                565                 570                 575     
Ala Arg Gln Glu Met Val Arg Arg Ser Arg Gly Gln Leu Glu Arg Ser
            580                 585                 590         
Pro Ser Gly Ser Ala Phe Gly Ser Gln Glu Asn Leu Arg Trp Arg Lys
        595                 600                 605             
Asp Met Thr His Trp Arg Gln Asn Thr Glu Lys Leu Asp Lys Ser Arg
    610                 615                 620                 
Ala Glu Ile Glu His Glu Ala Leu Ile Asp Gly Asn Leu Ala Thr Glu
625                 630                 635                 640 
Ala Asn Leu Ile Ile Leu Asp Thr Leu Glu Ile Val Val Gln Thr Val
                645                 650                 655     
Ser Val Thr Glu Ser Lys Glu Ser Ile Leu Gly Gly Val Leu Lys Val
            660                 665                 670         
Leu Leu His Ser Met Ala Cys Asn Gln Ser Ala Val Tyr Leu Gln His
        675                 680                 685             
Cys Phe Ala Thr Gln Arg Ala Leu Val Ser Lys Phe Pro Glu Leu Leu
    690                 695                 700                 
Phe Glu Glu Glu Thr Glu Gln Cys Ala Asp Leu Cys Leu Arg Leu Leu
705                 710                 715                 720 
Arg His Cys Ser Ser Ser Ile Gly Thr Ile Arg Ser His Ala Ser Ala
                725                 730                 735     
Ser Leu Tyr Leu Leu Met Arg Gln Asn Phe Glu Ile Gly Asn Asn Phe
            740                 745                 750         
Ala Arg Val Lys Met Gln Val Thr Met Ser Leu Ser Ser Leu Val Gly
        755                 760                 765             
Thr Ser Gln Asn Phe Asn Glu Glu Phe Leu Arg Arg Ser Leu Lys Thr
    770                 775                 780                 
Ile Leu Thr Tyr Ala Glu Glu Asp Leu Glu Leu Arg Glu Thr Thr Phe
785                 790                 795                 800 
Pro Asp Gln Val Gln Asp Leu Val Phe Asn Leu His Met Ile Leu Ser
                805                 810                 815     
Asp Thr Val Lys Met Lys Glu His Gln Glu Asp Pro Glu Met Leu Ile
            820                 825                 830         
Asp Leu Met Tyr Arg Ile Ala Lys Gly Tyr Gln Thr Ser Pro Asp Leu
        835                 840                 845             
Arg Leu Thr Trp Leu Gln Asn Met Ala Gly Lys His Ser Glu Arg Ser
    850                 855                 860                 
Asn His Ala Glu Ala Ala Gln Cys Leu Val His Ser Ala Ala Leu Val
865                 870                 875                 880 
Ala Glu Tyr Leu Ser Met Leu Glu Asp Arg Lys Tyr Leu Pro Val Gly
                885                 890                 895     
Cys Val Thr Phe Gln Asn Ile Ser Ser Asn Val Leu Glu Glu Ser Ala
            900                 905                 910         
Val Ser Asp Asp Val Val Ser Pro Asp Glu Glu Gly Ile Cys Ser Gly
        915                 920                 925             
Lys Tyr Phe Thr Glu Ser Gly Leu Val Gly Leu Leu Glu Gln Ala Ala
    930                 935                 940                 
Ala Ser Phe Ser Met Ala Gly Met Tyr Glu Ala Val Asn Glu Val Tyr
945                 950                 955                 960 
Lys Val Leu Ile Pro Ile His Glu Ala Asn Arg Asp Ala Lys Lys Leu
                965                 970                 975     
Ser Thr Ile His Gly Lys Leu Gln Glu Ala Phe Ser Lys Ile Val His
            980                 985                 990         
Gln Ser Thr Gly Trp Glu Arg Met Phe Gly Thr Tyr Phe Arg Val Gly
        995                 1000                1005            
Phe Tyr Gly Thr Lys Phe Gly Asp Leu Asp Glu Gln Glu Phe Val Tyr
    1010                1015                1020                
Lys Glu Pro Ala Ile Thr Lys Leu Ala Glu Ile Ser His Arg Leu Glu
1025                1030                1035                1040
Gly Phe Tyr Gly Glu Arg Phe Gly Glu Asp Val Val Glu Val Ile Lys
                1045                1050                1055    
Asp Ser Asn Pro Val Asp Lys Cys Lys Leu Asp Pro Asn Lys Ala Tyr
            1060                1065                1070        
Ile Gln Ile Thr Tyr Val Glu Pro Tyr Phe Asp Thr Tyr Glu Met Lys
        1075                1080                1085            
Asp Arg Ile Thr Tyr Phe Asp Lys Asn Tyr Asn Leu Arg Arg Phe Met
    1090                1095                1100                
Tyr Cys Thr Pro Phe Thr Leu Asp Gly Arg Ala His Gly Glu Leu His
1105                1110                1115                1120
Glu Gln Phe Lys Arg Lys Thr Ile Leu Thr Thr Ser His Ala Phe Pro
                1125                1130                1135    
Tyr Ile Lys Thr Arg Val Asn Val Thr His Lys Glu Glu Ile Ile Leu
            1140                1145                1150        
Thr Pro Ile Glu Val Ala Ile Glu Asp Met Gln Lys Lys Thr Gln Glu
        1155                1160                1165            
Leu Ala Phe Ala Thr His Gln Asp Pro Ala Asp Pro Lys Met Leu Gln
    1170                1175                1180                
Met Val Leu Gln Gly Ser Val Gly Thr Thr Val Asn Gln Gly Pro Leu
1185                1190                1195                1200
Glu Val Ala Gln Val Phe Leu Ser Glu Ile Pro Ser Asp Pro Lys Leu
                1205                1210                1215    
Phe Arg His His Asn Lys Leu Arg Leu Cys Phe Lys Asp Phe Thr Lys
            1220                1225                1230        
Arg Cys Glu Asp Ala Leu Arg Lys Asn Lys Ser Leu Ile Gly Pro Asp
        1235                1240                1245            
Gln Lys Glu Tyr Gln Arg Glu Leu Glu Arg Asn Tyr His Arg Leu Lys
    1250                1255                1260                
Glu Ala Leu Gln Pro Leu Ile Asn Arg Lys Ile Pro Gln Leu Tyr Lys
1265                1270                1275                1280
Ala Val Leu Pro Val Thr Cys His Arg Asp Ser Phe Ser Arg Met Ser
                1285                1290                1295    
Leu Arg Lys Met Asp Leu
            1300        


<210> 7382
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 7382
Met Ala Leu Tyr Tyr Asp His Gln Ile Glu Ala Pro Asp Ala Ala Gly
 1               5                  10                  15      
Ser Pro Ser Phe Ile Ser Trp His Pro Val His Pro Phe Leu Ala Val
            20                  25                  30          
Ala Tyr Ile Ser Thr Thr Ser Thr Gly Ser Val Asp Ile Tyr Leu Glu
        35                  40                  45              
Gln Gly Glu Cys Val Pro Asp Thr His Val Glu Arg Pro Phe Arg Val
    50                  55                  60                  
Ala Ser Leu Cys Trp His Pro Thr Arg Leu Val Leu Ala Val Gly Trp
65                  70                  75                  80  
Glu Thr Gly Glu Val Thr Val Phe Asn Lys Gln Asp Lys Glu Gln His
                85                  90                  95      
Thr Met Pro Leu Thr His Thr Ala Asp Ile Thr Val Leu Arg Trp Ser
            100                 105                 110         
Pro Ser Gly Asn Cys Leu Leu Ser Gly Asp Arg Leu Gly Val Leu Leu
        115                 120                 125             
Leu Trp Arg Leu Asp Gln Arg Gly Arg Val Gln Gly Thr Pro Leu Leu
    130                 135                 140                 
Lys His Glu Tyr Gly Lys His Leu Thr His Cys Ile Phe Arg Leu Pro
145                 150                 155                 160 
Pro Pro Gly Glu Asp Leu Val Gln Leu Ala Lys Ala Ala Val Ser Gly
                165                 170                 175     
Asp Glu Lys Ala Leu Asp Met Phe Asn Trp Lys Lys Ser Ser Ser Gly
            180                 185                 190         
Ser Leu Leu Lys Met Gly Ser His Glu Gly Leu Leu Phe Phe Val Ser
        195                 200                 205             
Leu Met Asp Gly Thr Val His Tyr Val Asp Glu Lys Gly Lys Thr Thr
    210                 215                 220                 
Gln Val Val Ser Ala Asp Ser Thr Ile Gln Met Leu Phe Tyr Met Glu
225                 230                 235                 240 
Lys Arg Glu Ala Leu Val Val Val Thr Glu Asn Leu Arg Leu Ser Leu
                245                 250                 255     
Tyr Thr Val Pro Pro Glu Gly Lys Ala Glu Glu Val Met Lys Val Lys
            260                 265                 270         
Leu Ser Gly Lys Thr Gly Arg Arg Ala Asp Ile Ala Leu Ile Glu Gly
        275                 280                 285             
Ser Leu Leu Val Met Ala Val Gly Glu Ala Ala Leu Arg Phe Trp Asp
    290                 295                 300                 
Ile Glu Arg Gly Glu Asn Tyr Ile Leu Ser Pro Asp Glu Lys Phe Gly
305                 310                 315                 320 
Phe Glu Lys Gly Glu Asn Met Asn Cys Val Cys Tyr Cys Lys Val Lys
                325                 330                 335     
Gly Leu Leu Ala Ala Gly Thr Asp Arg Gly Arg Val Ala Met Trp Arg
            340                 345                 350         
Lys Val Pro Asp Phe Leu Gly Ser Pro Gly Ala Glu Gly Lys Asp Arg
        355                 360                 365             
Trp Ala Leu Gln Thr Pro Thr Glu Leu Gln Gly Asn Ile Thr Gln Ile
    370                 375                 380                 
Gln Trp Gly Ser Arg Lys Asn Leu Leu Ala Val Asn Ser Val Ile Ser
385                 390                 395                 400 
Val Ala Ile Leu Ser Glu Arg Ala Met Ser Ser His Phe His Gln Gln
                405                 410                 415     
Val Ala Ala Met Gln Val Ser Pro Ser Leu Leu Asn Val Cys Phe Leu
            420                 425                 430         
Ser Thr Gly Val Ala His Ser Leu Arg Thr Asp Met His Ile Ser Gly
        435                 440                 445             
Val Phe Ala Thr Lys Asp Ala Val Ala Val Trp Asn Gly Arg Gln Val
    450                 455                 460                 
Ala Ile Phe Glu Leu Ser Gly Ala Ala Ile Arg Ser Ala Gly Thr Phe
465                 470                 475                 480 
Leu Cys Glu Thr Pro Val Leu Ala Met His Glu Glu Asn Val Tyr Thr
                485                 490                 495     
Val Glu Ser Asn Arg Val Gln Val Arg Thr Trp Gln Gly Thr Val Lys
            500                 505                 510         
Gln Leu Leu Leu Phe Ser Glu Thr Glu Gly Asn Pro Cys Phe Leu Asp
        515                 520                 525             
Ile Cys Gly Asn Phe Leu Val Val Gly Thr Asp Leu Ala Leu Phe Lys
    530                 535                 540                 
Ser Phe Asp Leu Ser Arg Arg Glu Ala Lys Ala His Cys Ser Cys Arg
545                 550                 555                 560 
Ser Leu Ala Glu Leu Val Pro Gly Val Gly Gly Ile Ala Ser Leu Arg
                565                 570                 575     
Cys Ser Ser Ser Gly Ser Thr Ile Ser Ile Leu Pro Ser Lys Ala Asp
            580                 585                 590         
Asn Ser Pro Asp Ser Lys Ile Cys Phe Tyr Asp Val Glu Met Asp Thr
        595                 600                 605             
Val Thr Val Phe Asp Phe Lys Thr Gly Gln Ile Asp Arg Arg Glu Thr
    610                 615                 620                 
Leu Ser Phe Asn Glu Gln Glu Thr Asn Lys Ser His Leu Phe Val Asp
625                 630                 635                 640 
Glu Gly Leu Lys Asn Tyr Val Pro Val Asn His Phe Trp Asp Gln Ser
                645                 650                 655     
Glu Pro Arg Leu Phe Val Cys Glu Ala Val Gln Glu Thr Pro Arg Ser
            660                 665                 670         
Gln Pro Gln Ser Ala Asn Gly Gln Pro Gln Asp Gly Arg Ala Gly Pro
        675                 680                 685             
Ala Ala Asp Val Leu Ile Leu Ser Phe Phe Ile Ser Glu Glu His Gly
    690                 695                 700                 
Phe Leu Leu His Glu Ser Phe Pro Arg Pro Ala Thr Ser His Ser Leu
705                 710                 715                 720 
Leu Gly Met Glu Val Pro Tyr Tyr Tyr Phe Thr Arg Lys Pro Glu Glu
                725                 730                 735     
Ala Asp Arg Glu Asp Glu Val Glu Pro Gly Cys His His Ile Pro Gln
            740                 745                 750         
Met Val Ser Arg Arg Pro Leu Arg Asp Phe Val Gly Leu Glu Asp Cys
        755                 760                 765             
Asp Lys Ala Thr Arg Asp Ala Met Leu His Phe Ser Phe Phe Val Thr
    770                 775                 780                 
Ile Gly Asp Met Asp Glu Ala Phe Lys Ser Ile Lys Leu Ile Lys Ser
785                 790                 795                 800 
Glu Ala Val Trp Glu Asn Met Ala Arg Met Cys Val Lys Thr Gln Arg
                805                 810                 815     
Leu Asp Val Ala Lys Val Cys Leu Gly Asn Met Gly His Ala Arg Gly
            820                 825                 830         
Ala Arg Ala Leu Arg Glu Ala Glu Gln Glu Pro Glu Leu Glu Ala Arg
        835                 840                 845             
Val Ala Val Leu Ala Thr Gln Leu Gly Met Leu Glu Asp Ala Glu Gln
    850                 855                 860                 
Leu Tyr Arg Lys Cys Lys Arg His Asp Leu Leu Asn Lys Phe Tyr Gln
865                 870                 875                 880 
Ala Ala Gly Arg Trp Gln Glu Ala Leu Gln Val Ala Glu His His Asp
                885                 890                 895     
Arg Val His Leu Arg Ser Thr Tyr His Arg Tyr Ala Gly His Leu Glu
            900                 905                 910         
Ala Ser Ala Asp Cys Ser Arg Ala Leu Ser Tyr Tyr Glu Lys Ser Asp
        915                 920                 925             
Thr His Arg Phe Glu Val Pro Arg Met Leu Ser Glu Asp Leu Pro Ser
    930                 935                 940                 
Leu Glu Leu Tyr Val Asn Lys Met Lys Asp Lys Thr Leu Trp Arg Trp
945                 950                 955                 960 
Trp Ala Gln Tyr Leu Glu Ser Gln Gly Glu Met Asp Ala Ala Leu His
                965                 970                 975     
Tyr Tyr Glu Leu Ala Arg Asp His Phe Ser Leu Val Arg Ile His Cys
            980                 985                 990         
Phe Gln Gly Asn Val Gln Lys Ala Ala Gln Ile Ala Asn Glu Thr Gly
        995                 1000                1005            
Asn Leu Ala Ala Ser Tyr His Leu Ala Arg Gln Tyr Glu Ser Gln Glu
    1010                1015                1020                
Glu Val Gly Gln Ala Val His Phe Tyr Thr Arg Ala Gln Ala Phe Lys
1025                1030                1035                1040
Asn Ala Ile Arg Leu Cys Lys Glu Asn Gly Leu Asp Asp Gln Leu Met
                1045                1050                1055    
Asn Leu Ala Leu Leu Ser Ser Pro Glu Asp Met Ile Glu Val Ala Arg
            1060                1065                1070        
Tyr Tyr Glu Glu Lys Gly Val Gln Met Asp Arg Ala Val Met Leu Tyr
        1075                1080                1085            
His Lys Ala Gly His Phe Ser Lys Ala Leu Glu Leu Ala Phe Ala Thr
    1090                1095                1100                
Gln Gln Phe Val Ala Leu Gln Leu Ile Ala Glu Asp Leu Asp Glu Thr
1105                1110                1115                1120
Ser Asp Pro Ala Leu Leu Ala Arg Cys Ser Asp Phe Phe Ile Glu His
                1125                1130                1135    
Ser Gln Tyr Glu Arg Ala Val Glu Leu Leu Leu Ala Ala Arg Lys Tyr
            1140                1145                1150        
Gln Glu Ala Leu Gln Leu Cys Leu Gly Gln Asn Met Ser Ile Thr Glu
        1155                1160                1165            
Glu Met Ala Glu Lys Met Thr Val Ala Lys Asp Ser Ser Asp Leu Pro
    1170                1175                1180                
Glu Glu Ser Arg Arg Glu Leu Leu Glu Gln Ile Ala Asp Cys Cys Met
1185                1190                1195                1200
Arg Gln Gly Ser Tyr His Leu Ala Thr Lys Lys Tyr Thr Gln Ala Gly
                1205                1210                1215    
Asn Lys Leu Lys Ala Met Arg Ala Leu Leu Lys Ser Gly Asp Thr Glu
            1220                1225                1230        
Lys Ile Thr Phe Phe Ala Ser Val Ser Arg Gln Lys Glu Ile Tyr Ile
        1235                1240                1245            
Met Ala Ala Asn Tyr Leu Gln Ser Leu Asp Trp Arg Lys Glu Pro Glu
    1250                1255                1260                
Ile Met Lys Asn Ile Ile Gly Phe Tyr Thr Lys Gly Arg Ala Leu Asp
1265                1270                1275                1280
Leu Leu Ala Gly Phe Tyr Asp Ala Cys Ala Gln Val Glu Ile Asp Glu
                1285                1290                1295    
Tyr Gln Asn Tyr Asp Lys Ala His Gly Ala Leu Thr Glu Ala Tyr Lys
            1300                1305                1310        
Cys Leu Ala Lys Ala Lys Ala Lys Ser Pro Leu Asp Gln Glu Thr Arg
        1315                1320                1325            
Leu Ala Gln Leu Gln Ser Arg Met Ala Leu Val Lys Arg Phe Ile Gln
    1330                1335                1340                
Ala Arg Arg Thr Tyr Thr Glu Asp Pro Lys Glu Ser Ile Lys Gln Cys
1345                1350                1355                1360
Glu Leu Leu Leu Glu Glu Pro Asp Leu Asp Ser Thr Ile Arg Ile Gly
                1365                1370                1375    
Asp Val Tyr Gly Phe Leu Val Glu His Tyr Val Arg Lys Glu Glu Tyr
            1380                1385                1390        
Gln Thr Ala Tyr Arg Phe Leu Glu Glu Met Arg Arg Arg Leu Pro Leu
        1395                1400                1405            
Ala Asn Met Ser Tyr Tyr Val Ser Pro Gln Ala Val Asp Ala Val His
    1410                1415                1420                
Arg Gly Leu Gly Leu Pro Leu Pro Arg Thr Val Pro Glu Gln Val Arg
1425                1430                1435                1440
His Asn Ser Met Glu Asp Ala Arg Glu Leu Asp Glu Glu Val Val Glu
                1445                1450                1455    
Glu Ala Asp Asp Asp Pro
            1460        


<210> 7383
<211> 737
<212> PRT
<213> Homo sapiens

<400> 7383
Met Pro Leu Asn Arg Thr Leu Ser Met Ser Ser Leu Pro Gly Leu Glu
 1               5                  10                  15      
Asp Trp Glu Asp Glu Phe Asp Leu Glu Asn Ala Val Leu Phe Glu Val
            20                  25                  30          
Ala Trp Glu Val Ala Asn Lys Val Gly Gly Ile Tyr Thr Val Leu Gln
        35                  40                  45              
Thr Lys Ala Lys Val Thr Gly Asp Glu Trp Gly Asp Asn Tyr Phe Leu
    50                  55                  60                  
Val Gly Pro Tyr Thr Glu Gln Gly Val Arg Thr Gln Val Glu Leu Leu
65                  70                  75                  80  
Glu Ala Pro Thr Pro Ala Leu Lys Arg Thr Leu Asp Ser Met Asn Ser
                85                  90                  95      
Lys Gly Cys Lys Val Tyr Phe Gly Arg Trp Leu Ile Glu Gly Gly Pro
            100                 105                 110         
Leu Val Val Leu Leu Asp Val Gly Ala Ser Ala Trp Ala Leu Glu Arg
        115                 120                 125             
Trp Lys Gly Glu Leu Trp Asp Thr Cys Asn Ile Gly Val Pro Trp Tyr
    130                 135                 140                 
Asp Arg Glu Ala Asn Asp Ala Val Leu Phe Gly Phe Leu Thr Thr Trp
145                 150                 155                 160 
Phe Leu Gly Glu Phe Leu Ala Gln Ser Glu Glu Lys Pro His Val Val
                165                 170                 175     
Ala His Phe His Glu Trp Leu Ala Gly Val Gly Leu Cys Leu Cys Arg
            180                 185                 190         
Ala Arg Arg Leu Pro Val Ala Thr Ile Phe Thr Thr His Ala Thr Leu
        195                 200                 205             
Leu Gly Arg Tyr Leu Cys Ala Gly Ala Val Asp Phe Tyr Asn Asn Leu
    210                 215                 220                 
Glu Asn Phe Asn Val Asp Lys Glu Ala Gly Glu Arg Gln Ile Tyr His
225                 230                 235                 240 
Arg Tyr Cys Met Glu Arg Ala Ala Ala His Cys Ala His Val Phe Thr
                245                 250                 255     
Thr Val Ser Gln Ile Thr Ala Ile Glu Ala Gln His Leu Leu Lys Arg
            260                 265                 270         
Lys Pro Asp Ile Val Thr Pro Asn Gly Leu Asn Val Lys Lys Phe Ser
        275                 280                 285             
Ala Met His Glu Phe Gln Asn Leu His Ala Gln Ser Lys Ala Arg Ile
    290                 295                 300                 
Gln Glu Phe Val Arg Gly His Phe Tyr Gly His Leu Asp Phe Asn Leu
305                 310                 315                 320 
Asp Lys Thr Leu Tyr Phe Phe Ile Ala Gly Arg Tyr Glu Phe Ser Asn
                325                 330                 335     
Lys Gly Ala Asp Val Phe Leu Glu Ala Leu Ala Arg Leu Asn Tyr Leu
            340                 345                 350         
Leu Arg Val Asn Gly Ser Glu Gln Thr Val Val Ala Phe Phe Ile Met
        355                 360                 365             
Pro Ala Arg Thr Asn Asn Phe Asn Val Glu Thr Leu Lys Gly Gln Ala
    370                 375                 380                 
Val Arg Lys Gln Leu Trp Asp Thr Ala Asn Thr Val Lys Glu Lys Phe
385                 390                 395                 400 
Gly Arg Lys Leu Tyr Glu Ser Leu Leu Val Gly Ser Leu Pro Asp Met
                405                 410                 415     
Asn Lys Met Leu Asp Lys Glu Asp Phe Thr Met Met Lys Arg Ala Ile
            420                 425                 430         
Phe Ala Thr Gln Arg Gln Ser Phe Pro Pro Val Cys Thr His Asn Met
        435                 440                 445             
Leu Asp Asp Ser Ser Asp Pro Ile Leu Thr Thr Ile Arg Arg Ile Gly
    450                 455                 460                 
Leu Phe Asn Ser Ser Ala Asp Arg Val Lys Val Ile Phe His Pro Glu
465                 470                 475                 480 
Phe Leu Ser Ser Thr Ser Pro Leu Leu Pro Val Asp Tyr Glu Glu Phe
                485                 490                 495     
Val Arg Gly Cys His Leu Gly Val Phe Pro Ser Tyr Tyr Glu Pro Trp
            500                 505                 510         
Gly Tyr Thr Pro Ala Glu Cys Thr Val Met Gly Ile Pro Ser Ile Ser
        515                 520                 525             
Thr Asn Leu Ser Gly Phe Gly Cys Phe Met Glu Glu His Ile Ala Asp
    530                 535                 540                 
Pro Ser Ala Tyr Gly Ile Tyr Ile Leu Asp Arg Arg Phe Arg Ser Leu
545                 550                 555                 560 
Asp Asp Ser Cys Ser Gln Leu Thr Ser Phe Leu Tyr Ser Phe Cys Gln
                565                 570                 575     
Gln Ser Arg Arg Gln Arg Ile Ile Gln Arg Asn Arg Thr Glu Arg Leu
            580                 585                 590         
Ser Asp Leu Leu Asp Trp Lys Tyr Leu Gly Arg Tyr Tyr Met Ser Ala
        595                 600                 605             
Arg His Met Ala Leu Ser Lys Ala Phe Pro Glu His Phe Thr Tyr Glu
    610                 615                 620                 
Pro Asn Glu Ala Asp Ala Ala Gln Gly Tyr Arg Tyr Pro Arg Pro Ala
625                 630                 635                 640 
Ser Val Pro Pro Ser Pro Ser Leu Ser Arg His Ser Ser Pro His Gln
                645                 650                 655     
Ser Glu Asp Glu Glu Asp Pro Arg Asn Gly Pro Leu Glu Glu Asp Gly
            660                 665                 670         
Glu Arg Tyr Asp Glu Asp Glu Glu Ala Ala Lys Asp Arg Arg Asn Ile
        675                 680                 685             
Arg Ala Pro Glu Trp Pro Arg Arg Ala Ser Cys Thr Ser Ser Thr Ser
    690                 695                 700                 
Gly Ser Lys Arg Asn Ser Val Asp Thr Ala Thr Ser Ser Ser Leu Ser
705                 710                 715                 720 
Thr Pro Ser Glu Pro Leu Ser Pro Thr Ser Ser Leu Gly Glu Glu Arg
                725                 730                 735     
Asn
    


<210> 7384
<211> 673
<212> PRT
<213> Homo sapiens

<400> 7384
Met Pro Leu Asn Arg Thr Leu Ser Met Ser Ser Leu Pro Gly Leu Glu
 1               5                  10                  15      
Asp Trp Glu Asp Glu Phe Asp Leu Glu Asn Ala Val Leu Phe Glu Val
            20                  25                  30          
Ala Trp Glu Val Ala Asn Lys Val Gly Gly Ile Tyr Thr Val Leu Gln
        35                  40                  45              
Thr Lys Ala Lys Val Thr Gly Asp Glu Trp Gly Asp Asn Tyr Phe Leu
    50                  55                  60                  
Val Gly Pro Tyr Thr Glu Gln Gly Val Arg Thr Gln Val Glu Leu Leu
65                  70                  75                  80  
Glu Ala Pro Thr Pro Ala Leu Lys Arg Thr Leu Asp Ser Met Asn Ser
                85                  90                  95      
Lys Gly Cys Lys Phe Leu Ala Gln Ser Glu Glu Lys Pro His Val Val
            100                 105                 110         
Ala His Phe His Glu Trp Leu Ala Gly Val Gly Leu Cys Leu Cys Arg
        115                 120                 125             
Ala Arg Arg Leu Pro Val Ala Thr Ile Phe Thr Thr His Ala Thr Leu
    130                 135                 140                 
Leu Gly Arg Tyr Leu Cys Ala Gly Ala Val Asp Phe Tyr Asn Asn Leu
145                 150                 155                 160 
Glu Asn Phe Asn Val Asp Lys Glu Ala Gly Glu Arg Gln Ile Tyr His
                165                 170                 175     
Arg Tyr Cys Met Glu Arg Ala Ala Ala His Cys Ala His Val Phe Thr
            180                 185                 190         
Thr Val Ser Gln Ile Thr Ala Ile Glu Ala Gln His Leu Leu Lys Arg
        195                 200                 205             
Lys Pro Asp Ile Val Thr Pro Asn Gly Leu Asn Val Lys Lys Phe Ser
    210                 215                 220                 
Ala Met His Glu Phe Gln Asn Leu His Ala Gln Ser Lys Ala Arg Ile
225                 230                 235                 240 
Gln Glu Phe Val Arg Gly His Phe Tyr Gly His Leu Asp Phe Asn Leu
                245                 250                 255     
Asp Lys Thr Leu Tyr Phe Phe Ile Ala Gly Arg Tyr Glu Phe Ser Asn
            260                 265                 270         
Lys Gly Ala Asp Val Phe Leu Glu Ala Leu Ala Arg Leu Asn Tyr Leu
        275                 280                 285             
Leu Arg Val Asn Gly Ser Glu Gln Thr Val Val Ala Phe Phe Ile Met
    290                 295                 300                 
Pro Ala Arg Thr Asn Asn Phe Asn Val Glu Thr Leu Lys Gly Gln Ala
305                 310                 315                 320 
Val Arg Lys Gln Leu Trp Asp Thr Ala Asn Thr Val Lys Glu Lys Phe
                325                 330                 335     
Gly Arg Lys Leu Tyr Glu Ser Leu Leu Val Gly Ser Leu Pro Asp Met
            340                 345                 350         
Asn Lys Met Leu Asp Lys Glu Asp Phe Thr Met Met Lys Arg Ala Ile
        355                 360                 365             
Phe Ala Thr Gln Arg Gln Ser Phe Pro Pro Val Cys Thr His Asn Met
    370                 375                 380                 
Leu Asp Asp Ser Ser Asp Pro Ile Leu Thr Thr Ile Arg Arg Ile Gly
385                 390                 395                 400 
Leu Phe Asn Ser Ser Ala Asp Arg Val Lys Val Ile Phe His Pro Glu
                405                 410                 415     
Phe Leu Ser Ser Thr Ser Pro Leu Leu Pro Val Asp Tyr Glu Glu Phe
            420                 425                 430         
Val Arg Gly Cys His Leu Gly Val Phe Pro Ser Tyr Tyr Glu Pro Trp
        435                 440                 445             
Gly Tyr Thr Pro Ala Glu Cys Thr Val Met Gly Ile Pro Ser Ile Ser
    450                 455                 460                 
Thr Asn Leu Ser Gly Phe Gly Cys Phe Met Glu Glu His Ile Ala Asp
465                 470                 475                 480 
Pro Ser Ala Tyr Gly Ile Tyr Ile Leu Asp Arg Arg Phe Arg Ser Leu
                485                 490                 495     
Asp Asp Ser Cys Ser Gln Leu Thr Ser Phe Leu Tyr Ser Phe Cys Gln
            500                 505                 510         
Gln Ser Arg Arg Gln Arg Ile Ile Gln Arg Asn Arg Thr Glu Arg Leu
        515                 520                 525             
Ser Asp Leu Leu Asp Trp Lys Tyr Leu Gly Arg Tyr Tyr Met Ser Ala
    530                 535                 540                 
Arg His Met Ala Leu Ser Lys Ala Phe Pro Glu His Phe Thr Tyr Glu
545                 550                 555                 560 
Pro Asn Glu Ala Asp Ala Ala Gln Gly Tyr Arg Tyr Pro Arg Pro Ala
                565                 570                 575     
Ser Val Pro Pro Ser Pro Ser Leu Ser Arg His Ser Ser Pro His Gln
            580                 585                 590         
Ser Glu Asp Glu Glu Asp Pro Arg Asn Gly Pro Leu Glu Glu Asp Gly
        595                 600                 605             
Glu Arg Tyr Asp Glu Asp Glu Glu Ala Ala Lys Asp Arg Arg Asn Ile
    610                 615                 620                 
Arg Ala Pro Glu Trp Pro Arg Arg Ala Ser Cys Thr Ser Ser Thr Ser
625                 630                 635                 640 
Gly Ser Lys Arg Asn Ser Val Asp Thr Ala Thr Ser Ser Ser Leu Ser
                645                 650                 655     
Thr Pro Ser Glu Pro Leu Ser Pro Thr Ser Ser Leu Gly Glu Glu Arg
            660                 665                 670         
Asn
    


<210> 7385
<211> 1783
<212> PRT
<213> Homo sapiens

<400> 7385
Met Ala Pro Ala Gln Asp Pro Glu Ser Glu Pro Gln Pro Glu Pro Cys
 1               5                  10                  15      
Pro Gly Arg Ala Gly Ala Ala Ala Arg Ala Arg Trp Cys Pro Gln Pro
            20                  25                  30          
Arg Pro Leu Val Leu Leu Ser Leu Gly Ala Leu Glu Phe Val Ser Leu
        35                  40                  45              
Ser Gln Gln Ala Phe Gln Ile Cys Pro Val Phe Val Val Cys Gly Leu
    50                  55                  60                  
Tyr Gln Asp Gly Asn Ser Asn Lys Ser Phe Leu Leu Arg Ser Trp Cys
65                  70                  75                  80  
Leu His Pro Glu Gly Thr Val Cys Ala Ser Ser Pro Glu Arg Lys Gly
                85                  90                  95      
Glu Ser His Gly Asp Leu Thr Leu Leu Pro Ser Leu Ser Gly Ala Glu
            100                 105                 110         
Lys Glu His Thr Gly Thr Cys Gly Met Gly Leu Asp Trp Ile Ile Arg
        115                 120                 125             
Phe Val Ala Val Phe Leu His His Ala Ser Phe Phe Val Gly Arg Gly
    130                 135                 140                 
Ser Tyr Arg Lys Val Glu Gly Val Glu Ser Cys Leu Val Leu Asp Asn
145                 150                 155                 160 
Arg Phe Val Pro Phe Phe Gly Ala Ser Ala Lys Ile His Ile Ala Leu
                165                 170                 175     
Gly Gly Cys Asp Glu Val Glu Gly Leu Pro Asn Leu Ser Leu Ile Arg
            180                 185                 190         
Ile Leu Leu Glu Glu Leu His Gln Val Gln Val Ile Gly Leu Leu Pro
        195                 200                 205             
Ala Ile Gln Leu Gln Gln Ala Val Asp Thr Cys Phe Gln Lys Asp Ser
    210                 215                 220                 
Ile Ile Asp Gly Ile Gln Thr His Ala Gln Leu Leu Ile Pro Gly Asp
225                 230                 235                 240 
Leu Ser Leu Ala Gly Phe Asp Ser Pro Arg Ser Leu Glu Arg Leu Ser
                245                 250                 255     
Asn Lys Ala Ser Pro Val Gly Gly His Leu Pro Cys Glu Lys Val Ile
            260                 265                 270         
Ser Ser Ser Arg Ser Arg Thr Val Cys Gln Leu Val Gly Cys Gly Val
        275                 280                 285             
Ser Gly Pro Gly Leu Leu Glu Ser Ala Arg Lys Arg Asn Gly Leu Glu
    290                 295                 300                 
Asn Lys Asp Phe Asn Gly Glu Pro Leu Gly Tyr Trp Ala Pro Glu Glu
305                 310                 315                 320 
Leu Gln Pro Gln Leu Cys Pro Gln Gly Val Ser Val Leu Val Gly Arg
                325                 330                 335     
Arg Pro Leu Lys Pro Gly Ser Ala Val Val Phe Ala Phe Ile Glu Gln
            340                 345                 350         
Gln Phe Val Gln Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala
        355                 360                 365             
His Ser Ile Pro Leu Gly Gln Ala Asp Pro Ser Leu Ala Arg Tyr Ile
    370                 375                 380                 
Ile Asp Leu Pro Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met
385                 390                 395                 400 
Arg Thr Val Arg Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg
                405                 410                 415     
Gly Val Val Trp Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr
            420                 425                 430         
Glu Ala Gly Val Cys Asp Asp Leu Glu Gln Gln Val Ala Arg Gly Asn
        435                 440                 445             
Gln Leu Val Asp Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr
    450                 455                 460                 
Thr Thr His Thr Gln Thr Asn Lys Thr Ser Ser Phe Cys Cys Ser Val
465                 470                 475                 480 
Arg Arg Gln Ala Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro
                485                 490                 495     
Pro Gly His Thr Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly
            500                 505                 510         
Ser Arg Thr Gly Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn
        515                 520                 525             
Leu Pro Ala Tyr Pro Ala Pro Gln His Pro Pro His Arg Thr Ala Ser
    530                 535                 540                 
Val Phe Gly Thr His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu
545                 550                 555                 560 
Ser Gly Ala Arg Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Asp
                565                 570                 575     
Ala Ala Pro Pro Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu
            580                 585                 590         
Ser His Leu Gly Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly
        595                 600                 605             
Ala Val Arg Lys Leu Gly Val Leu Met Ser His Val Ser His Ser Val
    610                 615                 620                 
Trp Asp Leu Leu Glu Met Val Thr Asp Arg Lys Ala Arg Glu Gly Leu
625                 630                 635                 640 
Ile Gly Gly Pro Gly Val Gly Glu Arg Arg Arg Val Pro Glu Ala Met
                645                 650                 655     
Thr Ile Gly Thr Ser Gln Arg Arg Thr Leu Gln Glu Ala Val Gly Ala
            660                 665                 670         
Pro Ile Trp Glu Arg Ser Ala Gly Pro Ser Pro Leu Arg Thr Ser Leu
        675                 680                 685             
Glu Ala Arg Thr Ser Cys Ser Phe Phe Arg Asn Gly Ser Lys Arg Ser
    690                 695                 700                 
Arg Ser Asp Met Cys Leu Ser Leu Val Lys Glu Asp Leu Thr Ser Trp
705                 710                 715                 720 
Asp Phe Ser Val Gly Trp Ser Ser Gln Gly Pro His Leu Cys Ala Ser
                725                 730                 735     
Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr Val
            740                 745                 750         
Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala Glu
        755                 760                 765             
Thr Val Gly Gly Thr Glu Glu Lys Met Lys Glu Arg Pro Glu Arg Glu
    770                 775                 780                 
Asp Arg Gly Ala Gly Thr Met Glu Ser Gly Val Gly Arg Gly Cys Gly
785                 790                 795                 800 
Arg Asn Gly Phe Val Gln Gln Asp Thr Leu Cys Pro Arg Lys Arg Trp
                805                 810                 815     
Val Ile Arg Glu His Glu Gly Ser Ser Val Arg Gly Glu Ser Pro Arg
            820                 825                 830         
Ala Ser Val Gly Phe Pro Ala Gly Ile Arg Gln Cys Arg Ala Pro Gln
        835                 840                 845             
Pro Thr Ser Pro Pro Ala Ser Arg Leu Ala Ser Lys Ser His Gly Ser
    850                 855                 860                 
Val Lys Arg Leu Arg Lys Met Ser Val Lys Ala Pro Glu Phe Ser Ser
865                 870                 875                 880 
Ser Pro Pro Val Thr Ala Gly Met Arg Gly Leu Val Leu Glu Asp Phe
                885                 890                 895     
Val Ile Phe Val Ser Ser Lys Leu Trp Val Arg Gly Gly Ala Arg Leu
            900                 905                 910         
Arg Met Arg Gly Gln Pro Ser Leu Pro Pro Gly Pro Ala Arg Val Ser
        915                 920                 925             
Gly Lys Ala Pro Arg Gln Arg Pro Arg Ser Ala Ala Gln Val Leu Ser
    930                 935                 940                 
Glu Pro Pro Leu Ser Arg Gly Ala Trp Arg Gly Leu Gly Asn Thr Arg
945                 950                 955                 960 
Ser Ala Trp His Ala Ala Arg Val Ala Ser Asp Arg Val Arg Pro Pro
                965                 970                 975     
Ala His Arg Arg Gly Glu Ser Leu Asp Leu Gly Ala Ser Leu His Val
            980                 985                 990         
Thr Asp Leu Pro Ser Gln Trp Gln Ala Phe Pro Gly Thr Val Ser Val
        995                 1000                1005            
Trp Arg Ser Ala Cys Val Gln Leu Pro Val His Ala Gly Pro Gln Thr
    1010                1015                1020                
Pro Leu Ser Leu Arg Cys Ser Cys Gln Gly Ala Thr Pro Lys Pro Glu
1025                1030                1035                1040
Pro Glu Pro Glu Gln Val Ile Lys Asn Tyr Thr Glu Glu Leu Lys Val
                1045                1050                1055    
Pro Pro Asp Glu Ser Glu Ser Met Arg Lys Ile Trp Leu Leu Leu Ser
            1060                1065                1070        
Lys Leu Pro Ser Ala Gln Pro Ala Arg Ser Leu Asp His Gly Ser Thr
        1075                1080                1085            
Pro Cys Leu Glu Pro Pro Ala Gly Pro Pro Thr His Thr Gln Pro Gln
    1090                1095                1100                
Ala Pro Glu Cys Gly Ser Gln Thr Pro Glu Gly Ala Pro Leu Pro Asp
1105                1110                1115                1120
Pro Val Ser Ser Pro Ala Pro Ser Pro Pro Pro Ala Ser Phe Ser Ala
                1125                1130                1135    
His Ala Leu Ala Pro Arg Ser Glu Arg Pro Pro Pro Ser Ser Gly Ile
            1140                1145                1150        
Leu Pro Cys Pro Ser Phe Pro Phe Gly Gly Phe Cys Cys His Val Gly
        1155                1160                1165            
Pro Val Leu Leu Asp Cys Ile Ile Cys Met Glu Lys Leu Ser Ala Ala
    1170                1175                1180                
Ser Gly Tyr Ser Asp Val Thr Asp Ser Lys Ala Ile Gly Pro Leu Ala
1185                1190                1195                1200
Val Gly Cys Leu Thr Lys Cys Ser His Ala Phe His Leu Leu Cys Leu
                1205                1210                1215    
Leu Ala Met Tyr Cys Asn Gly Asn Lys His Pro Cys Ala Val Ser Thr
            1220                1225                1230        
Val Leu Met Arg Glu Arg Leu Arg Ala Gly Ala Val Pro Thr Val Thr
        1235                1240                1245            
Pro Leu Gly Glu Lys Thr Gly Thr Gln Pro Gln Gly Lys Met Glu Val
    1250                1255                1260                
Leu Arg Phe Gln Met Ser Leu Pro Gly His Glu Asp Cys Gly Thr Ile
1265                1270                1275                1280
Leu Ile Val Tyr Ser Ile Pro His Gly Ile Gln Met Arg Gly Leu Leu
                1285                1290                1295    
Glu Ser Pro Thr Pro Gly His Ser Ser Ser His Pro Ala His Val Pro
            1300                1305                1310        
Ala Val Cys Pro Trp Ile Lys Ala Glu Asp Ala His Val Ala Lys Leu
        1315                1320                1325            
Arg Pro Pro Gly Pro Leu Arg Pro Gly Pro Trp Arg Ala Gly Asn Gly
    1330                1335                1340                
Glu Ala Val Pro Gly Leu Arg Gly Pro Glu His Pro Asn Pro Gly Lys
1345                1350                1355                1360
Pro Phe Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn
                1365                1370                1375    
Ala Gln Gly Arg Lys Ile Thr Ala Trp Asp Leu Glu Gly Lys Val Thr
            1380                1385                1390        
Ala Thr Thr Phe Ser Leu Glu Gln Pro Arg Cys Val Phe Asp Gly Leu
        1395                1400                1405            
Ala Ser Ala Ser Asp Thr Val Trp Leu Val Val Ala Phe Ser Asn Ala
    1410                1415                1420                
Ser Arg Gly Phe Gln Asn Pro Glu Thr Leu Ala Asp Ile Pro Ala Ser
1425                1430                1435                1440
Pro Gln Leu Leu Thr Asp Gly His Tyr Met Thr Leu Pro Val Ser Pro
                1445                1450                1455    
Asp Gln Leu Pro Cys Asp Asp Pro Met Ala Gly Ser Gly Gly Ala Pro
            1460                1465                1470        
Val Leu Arg Val Gly His Asp His Gly Cys His Gln Gln Pro Phe Cys
        1475                1480                1485            
Asn Ala Pro Leu Pro Gly Pro Gly Pro Tyr Arg Pro Cys Arg Ala Pro
    1490                1495                1500                
Ser Pro Ala Lys Arg Gln Thr Glu Pro Leu Cys Gly Ala Pro Gly Ala
1505                1510                1515                1520
Leu Gly Pro Gln Ala Ala Ala His Asp Gly Phe Glu Gln Asn Met Ser
                1525                1530                1535    
Arg Glu Arg His Cys Val Glu Leu Phe Ile Lys Trp His Leu Lys Tyr
            1540                1545                1550        
Ser Pro Gly Leu Cys Ser Trp Gly Asn Thr Thr Lys Ser Ile Gly Pro
        1555                1560                1565            
Glu His Asn Gly Ser Met Val Arg Asn Lys Cys Ile Val Lys Lys Glu
    1570                1575                1580                
Lys Gln Gln Leu Leu Arg Gly Asn Asp Leu Gln Met Thr Gln Gln Ala
1585                1590                1595                1600
Lys His Gln Arg Asn Ser Asp Gly Ser Ser Thr Glu Pro Ala Lys Ala
                1605                1610                1615    
Ile Lys Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser Gly Pro
            1620                1625                1630        
Val Val Leu Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser
        1635                1640                1645            
Leu Asp Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly
    1650                1655                1660                
Met Asp Leu Ile Glu Val Ser Gly Asn Gly Cys Gly Val Glu Glu Glu
1665                1670                1675                1680
Asn Phe Glu Gly Leu Thr Leu Lys His His Thr Ser Lys Ile Gln Glu
                1685                1690                1695    
Phe Ala Asp Leu Thr Arg Val Glu Thr Phe Gly Phe Arg Gly Lys Ala
            1700                1705                1710        
Leu Ser Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His
        1715                1720                1725            
Val Ser Ala Lys Val Gly Thr Arg Leu Val Phe Asp His Asp Gly Lys
    1730                1735                1740                
Ile Ile Gln Lys Thr Pro Tyr Pro His Pro Arg Gly Thr Thr Val Ser
1745                1750                1755                1760
Val Lys Gln Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe Gln
                1765                1770                1775    
Arg Asn Ile Lys Lys Val Gln
            1780            


<210> 7386
<211> 1270
<212> PRT
<213> Homo sapiens

<400> 7386
Met Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg
 1               5                  10                  15      
Thr Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg
            20                  25                  30          
Phe Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu
        35                  40                  45              
Ile His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn
    50                  55                  60                  
Lys Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His
65                  70                  75                  80  
Gly Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro
                85                  90                  95      
Gly Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg
            100                 105                 110         
Pro Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg
        115                 120                 125             
Thr Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile
    130                 135                 140                 
Leu Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln
145                 150                 155                 160 
Ser Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser
                165                 170                 175     
Ala Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys
            180                 185                 190         
Pro Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr
        195                 200                 205             
Thr Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg
    210                 215                 220                 
Asp Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp
225                 230                 235                 240 
Asn Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala
                245                 250                 255     
Arg Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp
            260                 265                 270         
Asp Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly
        275                 280                 285             
Asp Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala
    290                 295                 300                 
Val Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg
305                 310                 315                 320 
Lys Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala
                325                 330                 335     
Thr Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu
            340                 345                 350         
Pro Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly
        355                 360                 365             
Gly Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala
    370                 375                 380                 
Val Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu
385                 390                 395                 400 
Leu Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu
                405                 410                 415     
Cys Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val
            420                 425                 430         
Ala Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp
        435                 440                 445             
Phe Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg
    450                 455                 460                 
Glu His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu
465                 470                 475                 480 
Glu Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly
                485                 490                 495     
Glu Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp
            500                 505                 510         
Pro Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu
        515                 520                 525             
Arg Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys
    530                 535                 540                 
Val Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg
545                 550                 555                 560 
Cys Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala
                565                 570                 575     
Ser Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu
            580                 585                 590         
Phe Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu
        595                 600                 605             
Thr Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe
    610                 615                 620                 
Thr Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu
625                 630                 635                 640 
Glu Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp
                645                 650                 655     
Thr Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg
            660                 665                 670         
Glu Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu
        675                 680                 685             
Ser Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn
    690                 695                 700                 
Asp Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser
705                 710                 715                 720 
Arg Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro
                725                 730                 735     
Ser Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile
            740                 745                 750         
Asp Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met
        755                 760                 765             
Ala Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro
    770                 775                 780                 
Gly Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala Arg
785                 790                 795                 800 
Ser Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro Glu
                805                 810                 815     
Gln Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu Gln
            820                 825                 830         
Gly Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn Leu
        835                 840                 845             
Ala Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr Ala
    850                 855                 860                 
Ala Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly Ser
865                 870                 875                 880 
Gly Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly Val
                885                 890                 895     
Thr Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser Phe
            900                 905                 910         
Gln Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro Gly
        915                 920                 925             
Gly His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His His
    930                 935                 940                 
His His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp Thr
945                 950                 955                 960 
Phe Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser Gly
                965                 970                 975     
Val Pro Lys Pro Pro Ala Ala Ser Ile Leu His Ser His Ser Tyr Ser
            980                 985                 990         
Asp Glu Phe Gly Pro Ser Gly Thr Asp Phe Thr Arg Arg Gln Leu Ser
        995                 1000                1005            
Leu Gln Asp Asn Leu Gln His Met Leu Ser Pro Pro Gln Ile Thr Ile
    1010                1015                1020                
Gly Pro Gln Arg Pro Ala Pro Ser Gly Pro Gly Gly Gly Ser Gly Gly
1025                1030                1035                1040
Gly Ser Gly Gly Gly Gly Gly Gly Gln Pro Pro Pro Leu Gln Arg Gly
                1045                1050                1055    
Lys Ser Gln Gln Leu Thr Val Ser Ala Ala Gln Lys Pro Arg Pro Ser
            1060                1065                1070        
Ser Gly Asn Leu Leu Gln Ser Pro Glu Pro Ser Tyr Gly Pro Ala Arg
        1075                1080                1085            
Pro Arg Gln Gln Ser Leu Ser Lys Glu Gly Ser Ile Gly Gly Ser Gly
    1090                1095                1100                
Gly Ser Gly Gly Gly Gly Gly Gly Gly Leu Lys Pro Ser Ile Thr Lys
1105                1110                1115                1120
Gln His Ser Gln Thr Pro Ser Thr Leu Asn Pro Thr Met Pro Ala Ser
                1125                1130                1135    
Glu Arg Thr Val Ala Trp Val Ser Asn Met Pro His Leu Ser Ala Asp
            1140                1145                1150        
Ile Glu Ser Ala His Ile Glu Arg Glu Glu Tyr Lys Leu Lys Glu Tyr
        1155                1160                1165            
Ser Lys Ser Met Asp Glu Ser Arg Leu Asp Arg Val Lys Glu Tyr Glu
    1170                1175                1180                
Glu Glu Ile His Ser Leu Lys Glu Arg Leu His Met Ser Asn Arg Lys
1185                1190                1195                1200
Leu Glu Glu Tyr Glu Arg Arg Leu Leu Ser Gln Glu Glu Gln Thr Ser
                1205                1210                1215    
Lys Ile Leu Met Gln Tyr Gln Ala Arg Leu Glu Gln Ser Glu Lys Arg
            1220                1225                1230        
Leu Arg Gln Gln Gln Ala Glu Lys Asp Ser Gln Ile Lys Ser Ile Ile
        1235                1240                1245            
Gly Ser Pro Ser Leu Gln Ala Asp Ala Gly Gly Gly Gly Ala Ala Pro
    1250                1255                1260                
Gly Pro Pro Arg His Gly
1265                1270


<210> 7387
<211> 1376
<212> PRT
<213> Homo sapiens

<400> 7387
Ser Ser Ser Ser Ser Thr Ser Ser Ser Phe Ser Pro Ser Phe Ser Pro
 1               5                  10                  15      
Ser Phe Ser Leu Leu Ser Pro Pro Ser Pro Arg Pro Leu Pro Pro Gly
            20                  25                  30          
Leu Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala
        35                  40                  45              
Met Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg
    50                  55                  60                  
Thr Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg
65                  70                  75                  80  
Phe Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu
                85                  90                  95      
Ile His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn
            100                 105                 110         
Lys Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His
        115                 120                 125             
Gly Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro
    130                 135                 140                 
Gly Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg
145                 150                 155                 160 
Pro Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg
                165                 170                 175     
Thr Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile
            180                 185                 190         
Leu Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln
        195                 200                 205             
Ser Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser
    210                 215                 220                 
Ala Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys
225                 230                 235                 240 
Pro Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr
                245                 250                 255     
Thr Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg
            260                 265                 270         
Asp Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp
        275                 280                 285             
Asn Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala
    290                 295                 300                 
Arg Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp
305                 310                 315                 320 
Asp Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly
                325                 330                 335     
Asp Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala
            340                 345                 350         
Val Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg
        355                 360                 365             
Lys Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala
    370                 375                 380                 
Thr Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu
385                 390                 395                 400 
Pro Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly
                405                 410                 415     
Gly Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala
            420                 425                 430         
Val Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu
        435                 440                 445             
Leu Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu
    450                 455                 460                 
Cys Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val
465                 470                 475                 480 
Ala Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp
                485                 490                 495     
Phe Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg
            500                 505                 510         
Glu His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu
        515                 520                 525             
Glu Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly
    530                 535                 540                 
Glu Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp
545                 550                 555                 560 
Pro Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu
                565                 570                 575     
Arg Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys
            580                 585                 590         
Val Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg
        595                 600                 605             
Cys Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala
    610                 615                 620                 
Ser Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu
625                 630                 635                 640 
Phe Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu
                645                 650                 655     
Thr Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe
            660                 665                 670         
Thr Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu
        675                 680                 685             
Glu Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp
    690                 695                 700                 
Thr Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg
705                 710                 715                 720 
Glu Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu
                725                 730                 735     
Ser Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn
            740                 745                 750         
Asp Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser
        755                 760                 765             
Arg Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro
    770                 775                 780                 
Ser Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile
785                 790                 795                 800 
Asp Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met
                805                 810                 815     
Ala Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro
            820                 825                 830         
Gly Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala Arg
        835                 840                 845             
Ser Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro Glu
    850                 855                 860                 
Gln Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu Gln
865                 870                 875                 880 
Gly Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn Leu
                885                 890                 895     
Ala Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr Ala
            900                 905                 910         
Ala Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly Ser
        915                 920                 925             
Gly Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly Val
    930                 935                 940                 
Thr Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser Phe
945                 950                 955                 960 
Gln Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro Gly
                965                 970                 975     
Gly His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His His
            980                 985                 990         
His His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp Thr
        995                 1000                1005            
Phe Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser Gly
    1010                1015                1020                
Val Pro Lys Pro Pro Ala Ala Ser Ile Leu His Ser His Ser Tyr Ser
1025                1030                1035                1040
Asp Glu Phe Gly Pro Ser Gly Thr Asp Phe Thr Arg Arg Gln Leu Ser
                1045                1050                1055    
Leu Gln Asp Asn Leu Gln His Met Leu Ser Pro Pro Gln Ile Thr Ile
            1060                1065                1070        
Gly Pro Gln Arg Pro Ala Pro Ser Gly Pro Gly Gly Gly Ser Gly Gly
        1075                1080                1085            
Gly Ser Gly Gly Gly Gly Gly Gly Gln Pro Pro Pro Leu Gln Arg Gly
    1090                1095                1100                
Lys Ser Gln Gln Leu Thr Val Ser Ala Ala Gln Lys Pro Arg Pro Ser
1105                1110                1115                1120
Ser Gly Asn Leu Leu Gln Ser Pro Glu Pro Ser Tyr Gly Pro Ala Arg
                1125                1130                1135    
Pro Arg Gln Gln Ser Leu Ser Lys Glu Gly Ser Ile Gly Gly Ser Gly
            1140                1145                1150        
Gly Ser Gly Gly Gly Gly Gly Gly Gly Leu Lys Pro Ser Ile Thr Lys
        1155                1160                1165            
Gln His Ser Gln Thr Pro Ser Thr Leu Asn Pro Thr Met Pro Ala Ser
    1170                1175                1180                
Glu Arg Thr Val Ala Trp Val Ser Asn Met Pro His Leu Ser Ala Asp
1185                1190                1195                1200
Ile Glu Ser Ala His Ile Glu Arg Glu Glu Tyr Lys Leu Lys Glu Tyr
                1205                1210                1215    
Ser Lys Ser Met Asp Glu Ser Arg Leu Asp Arg Val Lys Glu Tyr Glu
            1220                1225                1230        
Glu Glu Ile His Ser Leu Lys Glu Arg Leu His Met Ser Asn Arg Lys
        1235                1240                1245            
Leu Glu Glu Tyr Glu Arg Arg Leu Leu Ser Gln Glu Glu Gln Thr Ser
    1250                1255                1260                
Lys Ile Leu Met Gln Tyr Gln Ala Arg Leu Glu Gln Ser Glu Lys Arg
1265                1270                1275                1280
Leu Arg Gln Gln Gln Ala Glu Lys Asp Ser Gln Ile Lys Ser Ile Ile
                1285                1290                1295    
Gly Arg Leu Met Leu Val Glu Glu Glu Leu Arg Arg Asp His Pro Ala
            1300                1305                1310        
Met Ala Glu Pro Leu Pro Glu Pro Lys Lys Arg Leu Leu Asp Ala Gln
        1315                1320                1325            
Glu Arg Gln Leu Pro Pro Leu Gly Pro Thr Asn Pro Arg Val Thr Leu
    1330                1335                1340                
Ala Pro Pro Trp Asn Gly Leu Ala Pro Pro Ala Pro Pro Pro Pro Pro
1345                1350                1355                1360
Arg Leu Gln Ile Thr Glu Asn Gly Glu Phe Arg Asn Thr Ala Asp His
                1365                1370                1375    


<210> 7388
<211> 588
<212> PRT
<213> Homo sapiens

<400> 7388
Met Gly Gly Thr Ala Arg Gly Pro Gly Arg Lys Asp Ala Gly Pro Pro
 1               5                  10                  15      
Gly Ala Gly Leu Pro Pro Gln Gln Arg Arg Leu Gly Asp Gly Val Tyr
            20                  25                  30          
Asp Thr Phe Met Met Ile Asp Glu Thr Lys Cys Pro Pro Cys Ser Asn
        35                  40                  45              
Val Leu Cys Asn Pro Ser Glu Pro Pro Pro Pro Arg Arg Leu Asn Met
    50                  55                  60                  
Thr Thr Glu Gln Phe Thr Gly Asp His Thr Gln His Phe Leu Asp Gly
65                  70                  75                  80  
Gly Glu Met Lys Val Glu Gln Leu Phe Gln Glu Phe Gly Asn Arg Lys
                85                  90                  95      
Ser Asn Thr Ile Gln Ser Asp Gly Ile Ser Asp Ser Glu Lys Cys Ser
            100                 105                 110         
Pro Thr Val Ser Gln Gly Lys Ser Ser Asp Cys Leu Asn Thr Val Lys
        115                 120                 125             
Ser Asn Ser Ser Ser Lys Ala Pro Lys Val Val Pro Leu Thr Pro Glu
    130                 135                 140                 
Gln Ala Leu Lys Gln Tyr Lys His His Leu Thr Ala Tyr Glu Lys Leu
145                 150                 155                 160 
Glu Ile Ile Asn Tyr Pro Glu Ile Tyr Phe Val Gly Pro Asn Ala Lys
                165                 170                 175     
Lys Arg His Gly Val Ile Gly Gly Pro Asn Asn Gly Gly Tyr Asp Asp
            180                 185                 190         
Ala Asp Gly Ala Tyr Ile His Val Pro Arg Asp His Leu Ala Tyr Arg
        195                 200                 205             
Tyr Glu Val Leu Lys Ile Ile Gly Lys Gly Ser Phe Gly Gln Val Ala
    210                 215                 220                 
Arg Val Tyr Asp His Lys Leu Arg Gln Tyr Val Ala Leu Lys Met Val
225                 230                 235                 240 
Arg Asn Glu Lys Arg Phe His Arg Gln Ala Ala Glu Glu Ile Arg Ile
                245                 250                 255     
Leu Glu His Leu Lys Lys Gln Asp Lys Thr Gly Ser Met Asn Val Ile
            260                 265                 270         
His Met Leu Glu Ser Phe Thr Phe Arg Asn His Val Cys Met Ala Phe
        275                 280                 285             
Glu Leu Leu Ser Ile Asp Leu Tyr Glu Leu Ile Lys Lys Asn Lys Phe
    290                 295                 300                 
Gln Gly Phe Ser Val Gln Leu Val Arg Lys Phe Ala Gln Ser Ile Leu
305                 310                 315                 320 
Gln Ser Leu Asp Ala Leu His Lys Asn Lys Ile Ile His Cys Asp Leu
                325                 330                 335     
Lys Pro Glu Asn Ile Leu Leu Lys His His Gly Arg Ser Ser Thr Lys
            340                 345                 350         
Val Ile Asp Phe Gly Ser Ser Cys Phe Glu Tyr Gln Lys Leu Tyr Thr
        355                 360                 365             
Tyr Ile Gln Ser Arg Phe Tyr Arg Ala Pro Glu Ile Ile Leu Gly Ser
    370                 375                 380                 
Arg Tyr Ser Thr Pro Ile Asp Ile Trp Ser Phe Arg Cys Ile Leu Ala
385                 390                 395                 400 
Glu Leu Leu Thr Gly Gln Pro Leu Phe Pro Gly Glu Asp Glu Gly Asp
                405                 410                 415     
Gln Leu Ala Cys Met Met Glu Leu Leu Gly Met Pro Pro Pro Lys Leu
            420                 425                 430         
Leu Glu Gln Ser Lys Arg Ala Lys Tyr Phe Ile Asn Ser Lys Gly Ile
        435                 440                 445             
Pro Arg Tyr Cys Ser Val Thr Thr Gln Ala Asp Gly Arg Val Val Leu
    450                 455                 460                 
Val Gly Gly Arg Ser Arg Arg Gly Lys Lys Arg Gly Pro Pro Gly Ser
465                 470                 475                 480 
Lys Asp Trp Gly Thr Ala Leu Lys Gly Cys Asp Asp Tyr Leu Phe Ile
                485                 490                 495     
Glu Phe Leu Lys Arg Cys Leu His Trp Asp Pro Ser Ala Arg Leu Thr
            500                 505                 510         
Pro Ala Gln Ala Leu Arg His Pro Trp Ile Ser Lys Ser Val Pro Arg
        515                 520                 525             
Pro Leu Thr Thr Ile Asp Lys Val Ser Gly Lys Arg Val Val Asn Pro
    530                 535                 540                 
Ala Ser Ala Phe Gln Gly Leu Gly Ser Lys Leu Pro Pro Val Val Gly
545                 550                 555                 560 
Ile Ala Asn Lys Leu Lys Ala Asn Leu Met Ser Glu Thr Asn Gly Ser
                565                 570                 575     
Ile Pro Leu Cys Ser Val Leu Pro Lys Leu Ile Ser
            580                 585             


<210> 7389
<211> 391
<212> PRT
<213> Homo sapiens

<400> 7389
Met Ala Glu Glu Ser Ser Cys Thr Arg Asp Cys Met Ser Phe Ser Val
 1               5                  10                  15      
Leu Asn Trp Asp Gln Val Ser Arg Leu His Glu Val Leu Thr Glu Val
            20                  25                  30          
Val Pro Ile His Gly Arg Gly Asn Phe Pro Thr Leu Glu Ile Thr Leu
        35                  40                  45              
Lys Asp Ile Val Gln Thr Val Arg Ser Arg Leu Glu Glu Ala Gly Ile
    50                  55                  60                  
Lys Val His Asp Val Arg Leu Asn Gly Ser Ala Ala Gly His Val Leu
65                  70                  75                  80  
Val Lys Asp Asn Gly Leu Gly Cys Lys Asp Leu Asp Leu Ile Phe His
                85                  90                  95      
Val Ala Leu Pro Thr Glu Ala Glu Phe Gln Leu Val Arg Asp Val Val
            100                 105                 110         
Leu Cys Ser Leu Leu Asn Phe Leu Pro Glu Gly Val Asn Lys Leu Lys
        115                 120                 125             
Ile Ser Pro Val Thr Leu Lys Glu Ala Tyr Val Gln Lys Leu Val Lys
    130                 135                 140                 
Val Cys Thr Asp Thr Asp Arg Trp Ser Leu Ile Ser Leu Ser Asn Lys
145                 150                 155                 160 
Asn Gly Lys Asn Val Glu Leu Lys Phe Val Asp Ser Ile Arg Arg Gln
                165                 170                 175     
Phe Glu Phe Ser Val Asp Ser Phe Gln Ile Ile Leu Asp Ser Leu Leu
            180                 185                 190         
Phe Phe Tyr Asp Cys Ser Asn Asn Pro Ile Ser Glu His Phe His Pro
        195                 200                 205             
Thr Val Ile Gly Glu Ser Met Tyr Gly Asp Phe Glu Glu Ala Phe Asp
    210                 215                 220                 
His Leu Gln Asn Arg Leu Ile Ala Thr Lys Asn Pro Glu Glu Ile Arg
225                 230                 235                 240 
Gly Gly Gly Leu Leu Lys Tyr Ser Asn Leu Leu Val Arg Asp Phe Arg
                245                 250                 255     
Pro Thr Asp Gln Glu Glu Ile Lys Thr Leu Glu Arg Tyr Met Cys Ser
            260                 265                 270         
Arg Phe Phe Ile Asp Phe Pro Asp Ile Leu Glu Gln Gln Arg Lys Leu
        275                 280                 285             
Glu Thr Tyr Leu Gln Asn His Phe Ala Glu Glu Glu Arg Ser Lys Tyr
    290                 295                 300                 
Asp Tyr Leu Met Ile Leu Arg Arg Val Val Asn Glu Ser Thr Val Cys
305                 310                 315                 320 
Leu Met Gly His Glu Arg Arg Gln Thr Leu Asn Leu Ile Ser Leu Leu
                325                 330                 335     
Ala Leu Arg Val Leu Ala Glu Gln Asn Ile Ile Pro Ser Ala Thr Asn
            340                 345                 350         
Val Thr Cys Tyr Tyr Gln Pro Ala Pro Tyr Val Ser Asp Gly Asn Phe
        355                 360                 365             
Ser Asn Tyr Tyr Val Ala His Pro Pro Val Thr Tyr Ser Gln Pro Tyr
    370                 375                 380                 
Pro Thr Trp Leu Pro Cys Asn
385                 390     


<210> 7390
<211> 582
<212> PRT
<213> Homo sapiens

<400> 7390
Asp Gln Gly Gly Leu Gly Ile Ala Ile Ser Glu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Gly Val Ile Ile Lys Ser Leu Thr Glu His Gly Val Ala Ala Thr Asp
            20                  25                  30          
Gly Arg Leu Lys Val Gly Asp Gln Ile Leu Ala Val Asp Asp Glu Ile
        35                  40                  45              
Val Val Gly Tyr Pro Ile Glu Lys Phe Ile Ser Leu Leu Lys Thr Ala
    50                  55                  60                  
Lys Met Thr Val Lys Leu Thr Ile His Ala Glu Asn Pro Asp Ser Gln
65                  70                  75                  80  
Ala Val Pro Ser Ala Ala Gly Ala Ala Ser Gly Glu Lys Lys Asn Ser
                85                  90                  95      
Ser Gln Ser Leu Met Val Pro Gln Ser Gly Ser Pro Glu Pro Glu Ser
            100                 105                 110         
Ile Arg Asn Thr Ser Arg Ser Ser Thr Pro Ala Ile Phe Ala Ser Asp
        115                 120                 125             
Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr Thr Ile Glu Ile
    130                 135                 140                 
Ser Lys Gly Arg Thr Gly Leu Gly Leu Ser Ile Val Gly Gly Ser Asp
145                 150                 155                 160 
Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr Glu Glu Gly Ala
                165                 170                 175     
Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val
            180                 185                 190         
Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu Ala Ile Asn Val
        195                 200                 205             
Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu Tyr Arg Asp Glu
    210                 215                 220                 
Ala Pro Tyr Lys Glu Glu Glu Val Cys Asp Thr Leu Thr Ile Glu Leu
225                 230                 235                 240 
Gln Lys Lys Pro Gly Lys Gly Leu Gly Leu Ser Ile Val Gly Lys Arg
                245                 250                 255     
Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys Gly Gly Ile Ala
            260                 265                 270         
Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn
        275                 280                 285             
Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu
    290                 295                 300                 
Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly Arg Ile Lys Ala
305                 310                 315                 320 
Gly Pro Phe His Ser Glu Arg Arg Pro Ser Gln Ser Ser Gln Val Ser
                325                 330                 335     
Glu Gly Ser Leu Ser Ser Phe Thr Phe Pro Leu Ser Gly Ser Ser Thr
            340                 345                 350         
Ser Glu Ser Leu Glu Ser Ser Ser Lys Lys Asn Ala Leu Ala Ser Glu
        355                 360                 365             
Ile Gln Gly Leu Arg Thr Val Glu Met Lys Lys Gly Pro Thr Asp Ser
    370                 375                 380                 
Leu Gly Ile Ser Ile Ala Gly Gly Val Gly Ser Pro Leu Gly Asp Val
385                 390                 395                 400 
Pro Ile Phe Ile Ala Met Met His Pro Thr Gly Val Ala Ala Gln Thr
                405                 410                 415     
Gln Lys Leu Arg Val Gly Asp Arg Ile Val Thr Ile Cys Gly Thr Ser
            420                 425                 430         
Thr Glu Gly Met Thr His Thr Gln Ala Val Asn Leu Leu Lys Asn Ala
        435                 440                 445             
Ser Gly Ser Ile Glu Met Gln Val Val Ala Gly Gly Asp Val Ser Val
    450                 455                 460                 
Val Thr Gly His Gln Gln Glu Pro Ala Ser Ser Ser Leu Ser Phe Thr
465                 470                 475                 480 
Gly Leu Thr Ser Ser Ser Ile Phe Gln Asp Asp Leu Gly Pro Pro Gln
                485                 490                 495     
Cys Lys Ser Ile Thr Leu Glu Arg Gly Pro Asp Gly Leu Gly Phe Ser
            500                 505                 510         
Ile Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu Pro Ile Tyr Val
        515                 520                 525             
Lys Thr Val Phe Ala Lys Gly Ala Ala Ser Glu Asp Gly Arg Leu Lys
    530                 535                 540                 
Arg Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser Leu Glu Gly Val
545                 550                 555                 560 
Thr His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr Lys Gly Thr Val
                565                 570                 575     
Thr Leu Met Val Leu Ser
            580         


<210> 7391
<211> 2042
<212> PRT
<213> Homo sapiens

<400> 7391
Met Leu Glu Ala Ile Asp Lys Asn Arg Ala Leu His Ala Ala Glu Arg
 1               5                  10                  15      
Leu Gln Thr Lys Leu Arg Glu Arg Gly Asp Val Ala Asn Glu Asp Lys
            20                  25                  30          
Leu Ser Leu Leu Lys Ser Val Leu Gln Ser Pro Leu Phe Ser Gln Ile
        35                  40                  45              
Leu Ser Leu Gln Thr Ser Val Gln Gln Leu Lys Asp Gln Val Asn Ile
    50                  55                  60                  
Ala Thr Ser Ala Thr Ser Asn Ile Glu Tyr Ala His Val Pro His Leu
65                  70                  75                  80  
Ser Pro Ala Val Ile Pro Thr Leu Gln Asn Glu Ser Phe Leu Leu Ser
                85                  90                  95      
Pro Asn Asn Gly Asn Leu Glu Ala Leu Thr Gly Pro Gly Ile Pro His
            100                 105                 110         
Ile Asn Gly Lys Pro Ala Cys Asp Glu Phe Asp Gln Leu Ile Lys Asn
        115                 120                 125             
Met Ala Gln Gly Arg His Val Glu Val Phe Glu Leu Leu Lys Pro Pro
    130                 135                 140                 
Ser Gly Gly Leu Gly Phe Ser Val Val Gly Leu Arg Ser Glu Asn Arg
145                 150                 155                 160 
Gly Glu Leu Gly Ile Phe Val Gln Glu Ile Gln Glu Gly Ser Val Ala
                165                 170                 175     
His Arg Asp Gly Arg Leu Lys Glu Thr Asp Gln Ile Leu Ala Ile Asn
            180                 185                 190         
Gly Gln Ala Leu Asp Gln Thr Ile Thr His Gln Gln Ala Ile Ser Ile
        195                 200                 205             
Leu Gln Lys Ala Lys Asp Thr Val Gln Leu Val Ile Ala Arg Gly Ser
    210                 215                 220                 
Leu Pro Gln Leu Val Ser Pro Ile Val Ser Arg Ser Pro Ser Ala Ala
225                 230                 235                 240 
Ser Thr Ile Ser Ala His Ser Asn Pro Val His Trp Gln His Met Glu
                245                 250                 255     
Thr Ile Glu Leu Val Asn Asp Gly Ser Gly Leu Gly Phe Gly Ile Ile
            260                 265                 270         
Gly Gly Lys Ala Thr Gly Val Ile Val Lys Thr Ile Leu Pro Gly Gly
        275                 280                 285             
Val Ala Asp Gln His Gly Arg Leu Cys Ser Gly Asp His Ile Leu Lys
    290                 295                 300                 
Ile Gly Asp Thr Asp Leu Ala Gly Met Ser Ser Glu Gln Val Ala Gln
305                 310                 315                 320 
Val Leu Arg Gln Cys Gly Asn Arg Val Lys Leu Met Ile Ala Arg Gly
                325                 330                 335     
Ala Ile Glu Glu Arg Thr Ala Pro Thr Ala Leu Gly Ile Thr Leu Ser
            340                 345                 350         
Ser Ser Pro Thr Ser Thr Pro Glu Leu Arg Val Asp Ala Ser Thr Gln
        355                 360                 365             
Lys Gly Glu Glu Ser Glu Thr Phe Asp Val Glu Leu Thr Lys Asn Val
    370                 375                 380                 
Gln Gly Leu Gly Ile Thr Ile Ala Gly Tyr Ile Gly Asp Lys Lys Leu
385                 390                 395                 400 
Glu Pro Ser Gly Ile Phe Val Lys Ser Ile Thr Lys Ser Ser Ala Val
                405                 410                 415     
Glu His Asp Gly Arg Ile Gln Ile Gly Asp Gln Ile Ile Ala Val Asp
            420                 425                 430         
Gly Thr Asn Leu Gln Gly Phe Thr Asn Gln Gln Ala Val Glu Val Leu
        435                 440                 445             
Arg His Thr Gly Gln Thr Val Leu Leu Thr Leu Met Arg Arg Gly Met
    450                 455                 460                 
Lys Gln Glu Ala Glu Leu Met Ser Arg Glu Asp Val Thr Lys Asp Ala
465                 470                 475                 480 
Asp Leu Ser Pro Val Asn Ala Ser Ile Ile Lys Glu Asn Tyr Glu Lys
                485                 490                 495     
Asp Glu Asp Phe Leu Ser Ser Thr Arg Asn Thr Asn Ile Leu Pro Thr
            500                 505                 510         
Glu Glu Glu Gly Tyr Pro Leu Leu Ser Ala Glu Ile Glu Glu Ile Glu
        515                 520                 525             
Asp Ala Gln Lys Gln Glu Ala Ala Leu Leu Thr Lys Trp Gln Arg Ile
    530                 535                 540                 
Met Gly Ile Asn Tyr Glu Ile Val Val Ala His Val Ser Lys Phe Ser
545                 550                 555                 560 
Glu Asn Ser Gly Leu Gly Ile Ser Leu Glu Ala Thr Val Gly His His
                565                 570                 575     
Phe Ile Arg Ser Val Leu Pro Glu Gly Pro Val Gly His Ser Gly Lys
            580                 585                 590         
Leu Phe Ser Gly Asp Glu Leu Leu Glu Val Asn Gly Ile Thr Leu Leu
        595                 600                 605             
Gly Glu Asn His Gln Asp Val Val Asn Ile Leu Lys Glu Leu Pro Ile
    610                 615                 620                 
Glu Val Thr Met Val Cys Cys Arg Arg Thr Val Pro Pro Thr Thr Gln
625                 630                 635                 640 
Ser Glu Leu Asp Ser Leu Asp Leu Cys Asp Ile Glu Leu Thr Glu Lys
                645                 650                 655     
Pro His Val Asp Leu Gly Glu Phe Ile Gly Ser Ser Glu Thr Glu Asp
            660                 665                 670         
Pro Val Leu Ala Met Thr Asp Ala Gly Gln Ser Thr Glu Glu Val Gln
        675                 680                 685             
Ala Pro Leu Ala Met Trp Glu Ala Gly Ile Gln His Ile Glu Leu Glu
    690                 695                 700                 
Lys Gly Ser Lys Gly Leu Gly Phe Ser Ile Leu Asp Tyr Gln Asp Pro
705                 710                 715                 720 
Ile Asp Pro Ala Ser Thr Val Ile Ile Ile Arg Ser Leu Val Pro Gly
                725                 730                 735     
Gly Ile Ala Glu Lys Asp Gly Arg Leu Leu Pro Gly Asp Arg Leu Met
            740                 745                 750         
Phe Val Asn Asp Val Asn Leu Glu Asn Ser Ser Leu Glu Glu Ala Val
        755                 760                 765             
Glu Ala Leu Lys Gly Ala Pro Ser Gly Thr Val Arg Ile Gly Val Ala
    770                 775                 780                 
Lys Pro Leu Pro Leu Ser Pro Glu Glu Gly Tyr Val Ser Ala Lys Glu
785                 790                 795                 800 
Asp Ser Phe Leu Tyr Pro Pro His Ser Cys Glu Glu Ala Gly Leu Ala
                805                 810                 815     
Asp Lys Pro Leu Phe Arg Ala Asp Leu Ala Leu Val Gly Thr Asn Asp
            820                 825                 830         
Ala Asp Leu Val Asp Glu Ser Thr Phe Glu Ser Pro Tyr Ser Pro Glu
        835                 840                 845             
Asn Asp Ser Ile Tyr Ser Thr Gln Ala Ser Ile Leu Ser Leu His Gly
    850                 855                 860                 
Ser Ser Cys Gly Asp Gly Leu Asn Tyr Gly Ser Ser Leu Pro Ser Ser
865                 870                 875                 880 
Pro Pro Lys Asp Val Ile Glu Asn Ser Cys Asp Pro Val Leu Asp Leu
                885                 890                 895     
His Met Ser Leu Glu Glu Leu Tyr Thr Gln Asn Leu Leu Gln Arg Gln
            900                 905                 910         
Asp Glu Asn Thr Pro Ser Val Asp Ile Ser Met Gly Pro Ala Ser Gly
        915                 920                 925             
Phe Thr Ile Asn Asp Tyr Thr Pro Ala Asn Ala Ile Glu Gln Gln Tyr
    930                 935                 940                 
Glu Cys Glu Asn Thr Ile Val Trp Thr Glu Ser His Leu Pro Ser Glu
945                 950                 955                 960 
Val Ile Ser Ser Ala Glu Leu Pro Ser Val Leu Pro Asp Ser Ala Gly
                965                 970                 975     
Lys Gly Ser Glu Tyr Leu Leu Glu Gln Ser Ser Leu Ala Cys Asn Ala
            980                 985                 990         
Glu Cys Val Met Leu Gln Asn Val Ser Lys Glu Ser Phe Glu Arg Thr
        995                 1000                1005            
Ile Asn Ile Ala Lys Gly Asn Ser Ser Leu Gly Met Thr Val Ser Ala
    1010                1015                1020                
Asn Lys Asp Gly Leu Gly Met Ile Val Arg Ser Ile Ile His Gly Gly
1025                1030                1035                1040
Ala Ile Ser Arg Asp Gly Arg Ile Ala Ile Gly Asp Cys Ile Leu Ser
                1045                1050                1055    
Ile Asn Glu Glu Ser Thr Ile Ser Val Thr Asn Ala Gln Ala Arg Ala
            1060                1065                1070        
Met Leu Arg Arg His Ser Leu Ile Gly Pro Asp Ile Lys Ile Thr Tyr
        1075                1080                1085            
Val Pro Ala Glu His Leu Glu Glu Phe Lys Ile Ser Leu Gly Gln Gln
    1090                1095                1100                
Ser Gly Arg Val Met Ala Leu Asp Ile Phe Ser Ser Tyr Thr Gly Arg
1105                1110                1115                1120
Asp Ile Pro Glu Leu Pro Glu Arg Glu Glu Gly Glu Gly Glu Glu Ser
                1125                1130                1135    
Glu Leu Gln Asn Thr Ala Tyr Ser Asn Trp Asn Gln Pro Arg Arg Val
            1140                1145                1150        
Glu Leu Trp Arg Glu Pro Ser Lys Ser Leu Gly Ile Ser Ile Val Gly
        1155                1160                1165            
Gly Arg Gly Met Gly Ser Arg Leu Ser Asn Gly Glu Val Met Arg Gly
    1170                1175                1180                
Ile Phe Ile Lys His Val Leu Glu Asp Ser Pro Ala Gly Lys Asn Gly
1185                1190                1195                1200
Thr Leu Lys Pro Gly Asp Arg Ile Val Glu Val Asp Gly Met Asp Leu
                1205                1210                1215    
Arg Asp Ala Ser His Glu Gln Ala Val Glu Ala Ile Arg Lys Ala Gly
            1220                1225                1230        
Asn Pro Val Val Phe Met Val Gln Ser Ile Ile Asn Arg Pro Arg Lys
        1235                1240                1245            
Ser Pro Leu Pro Ser Leu Leu His Asn Leu Tyr Pro Lys Tyr Asn Phe
    1250                1255                1260                
Ser Ser Thr Asn Pro Phe Ala Asp Ser Leu Gln Ile Asn Ala Asp Lys
1265                1270                1275                1280
Ala Pro Ser Gln Ser Glu Ser Glu Pro Glu Lys Ala Pro Leu Cys Ser
                1285                1290                1295    
Val Pro Pro Pro Pro Pro Ser Ala Phe Ala Glu Met Gly Ser Asp His
            1300                1305                1310        
Thr Gln Ser Ser Ala Ser Lys Ile Ser Gln Asp Val Asp Lys Glu Asp
        1315                1320                1325            
Glu Phe Gly Tyr Ser Trp Lys Asn Ile Arg Glu Arg Tyr Gly Thr Leu
    1330                1335                1340                
Thr Gly Glu Leu His Met Ile Glu Leu Glu Lys Gly His Ser Gly Leu
1345                1350                1355                1360
Gly Leu Ser Leu Ala Gly Asn Lys Asp Arg Ser Arg Met Ser Val Phe
                1365                1370                1375    
Ile Val Gly Ile Asp Pro Asn Gly Ala Ala Gly Lys Asp Gly Arg Leu
            1380                1385                1390        
Gln Ile Ala Asp Glu Leu Leu Glu Ile Asn Gly Gln Ile Leu Tyr Gly
        1395                1400                1405            
Arg Ser His Gln Asn Ala Ser Ser Ile Ile Lys Cys Ala Pro Ser Lys
    1410                1415                1420                
Val Lys Ile Ile Phe Ile Arg Asn Lys Asp Ala Val Asn Gln Met Ala
1425                1430                1435                1440
Val Cys Pro Gly Asn Ala Val Glu Pro Leu Pro Ser Asn Ser Glu Asn
                1445                1450                1455    
Leu Gln Asn Lys Glu Thr Glu Pro Thr Val Thr Thr Ser Asp Ala Ala
            1460                1465                1470        
Val Asp Leu Ser Ser Phe Lys Asn Val Gln His Leu Glu Leu Pro Lys
        1475                1480                1485            
Asp Gln Gly Gly Leu Gly Ile Ala Ile Ser Glu Glu Asp Thr Leu Ser
    1490                1495                1500                
Gly Val Ile Ile Lys Ser Leu Thr Glu His Gly Val Ala Ala Thr Asp
1505                1510                1515                1520
Gly Arg Leu Lys Val Gly Asp Gln Ile Leu Ala Val Asp Asp Glu Ile
                1525                1530                1535    
Val Val Gly Tyr Pro Ile Glu Lys Phe Ile Ser Leu Leu Lys Thr Ala
            1540                1545                1550        
Lys Met Thr Val Lys Leu Thr Ile His Ala Glu Asn Pro Asp Ser Gln
        1555                1560                1565            
Ala Val Pro Ser Ala Ala Gly Ala Ala Ser Gly Glu Lys Lys Asn Ser
    1570                1575                1580                
Ser Gln Ser Leu Met Val Pro Gln Ser Gly Ser Pro Glu Pro Glu Ser
1585                1590                1595                1600
Ile Arg Asn Thr Ser Arg Ser Ser Thr Pro Ala Ile Phe Ala Ser Asp
                1605                1610                1615    
Pro Ala Thr Cys Pro Ile Ile Pro Gly Cys Glu Thr Thr Ile Glu Ile
            1620                1625                1630        
Ser Lys Gly Arg Thr Gly Leu Gly Leu Ser Ile Val Gly Gly Ser Asp
        1635                1640                1645            
Thr Leu Leu Gly Ala Ile Ile Ile His Glu Val Tyr Glu Glu Gly Ala
    1650                1655                1660                
Ala Cys Lys Asp Gly Arg Leu Trp Ala Gly Asp Gln Ile Leu Glu Val
1665                1670                1675                1680
Asn Gly Ile Asp Leu Arg Lys Ala Thr His Asp Glu Ala Ile Asn Val
                1685                1690                1695    
Leu Arg Gln Thr Pro Gln Arg Val Arg Leu Thr Leu Tyr Arg Asp Glu
            1700                1705                1710        
Ala Pro Tyr Lys Glu Glu Glu Val Cys Asp Thr Leu Thr Ile Glu Leu
        1715                1720                1725            
Gln Lys Lys Pro Gly Lys Gly Leu Gly Leu Ser Ile Val Gly Lys Arg
    1730                1735                1740                
Asn Asp Thr Gly Val Phe Val Ser Asp Ile Val Lys Gly Gly Ile Ala
1745                1750                1755                1760
Asp Ala Asp Gly Arg Leu Met Gln Gly Asp Gln Ile Leu Met Val Asn
                1765                1770                1775    
Gly Glu Asp Val Arg Asn Ala Thr Gln Glu Ala Val Ala Ala Leu Leu
            1780                1785                1790        
Lys Cys Ser Leu Gly Thr Val Thr Leu Glu Val Gly Arg Ile Lys Ala
        1795                1800                1805            
Gly Ser Ser Thr Ser Glu Ser Leu Glu Ser Ser Ser Lys Lys Asn Ala
    1810                1815                1820                
Leu Ala Ser Glu Ile Gln Gly Leu Arg Thr Val Glu Met Lys Lys Gly
1825                1830                1835                1840
Pro Thr Asp Ser Leu Gly Ile Ser Ile Ala Gly Gly Val Gly Ser Pro
                1845                1850                1855    
Leu Gly Asp Val Pro Ile Phe Ile Ala Met Met His Pro Thr Gly Val
            1860                1865                1870        
Ala Ala Gln Thr Gln Lys Leu Arg Val Gly Asp Arg Ile Val Thr Ile
        1875                1880                1885            
Cys Gly Thr Ser Thr Glu Gly Met Thr His Thr Gln Ala Val Asn Leu
    1890                1895                1900                
Leu Lys Asn Ala Ser Gly Ser Ile Glu Met Gln Val Val Ala Gly Gly
1905                1910                1915                1920
Asp Val Ser Val Val Thr Gly His Gln Gln Glu Pro Ala Ser Ser Ser
                1925                1930                1935    
Leu Ser Phe Thr Gly Leu Thr Ser Ser Ser Ile Phe Gln Asp Asp Leu
            1940                1945                1950        
Gly Pro Pro Gln Cys Lys Ser Ile Thr Leu Glu Arg Gly Pro Asp Gly
        1955                1960                1965            
Leu Gly Phe Ser Ile Val Gly Gly Tyr Gly Ser Pro His Gly Asp Leu
    1970                1975                1980                
Pro Ile Tyr Val Lys Thr Val Phe Ala Lys Gly Ala Ala Ser Glu Asp
1985                1990                1995                2000
Gly Arg Leu Lys Arg Gly Asp Gln Ile Ile Ala Val Asn Gly Gln Ser
                2005                2010                2015    
Leu Glu Gly Val Thr His Glu Glu Ala Val Ala Ile Leu Lys Arg Thr
            2020                2025                2030        
Lys Gly Thr Val Thr Leu Met Val Leu Ser
        2035                2040        


<210> 7392
<211> 431
<212> PRT
<213> Homo sapiens

<400> 7392
Met Leu Ser Asp Glu Leu Glu Ser Lys Pro Glu Leu Leu Val Gln Phe
 1               5                  10                  15      
Val Gln Asn Thr Ser Ile Pro Leu Gly Gln Gly Leu Val Glu Ser Glu
            20                  25                  30          
Ala Lys Asp Ile Thr Cys Leu Ser Leu Leu Pro Val Thr Glu Ala Ser
        35                  40                  45              
Glu Cys Ser Arg Leu Met Leu Pro Asp Asp Thr Thr Asn His Ser Asn
    50                  55                  60                  
Ser Ser Lys Glu Val Pro Ser Ser Ala Val Leu Arg Ser Leu Arg Val
65                  70                  75                  80  
Asn Val Gly Pro Asp Gly Glu Glu Thr Arg Ala Gln Thr Val Gln Lys
                85                  90                  95      
Ser Pro Glu Phe Leu Ser Thr Ser Glu Ser Ser Ser Leu Leu Gln Asp
            100                 105                 110         
Leu Gln Pro Ser Asp Ser Thr Ser Phe Ile Leu Leu Asn Leu Thr Arg
        115                 120                 125             
Ala Gly Leu Gly Ser Ser Ala Glu His Leu Val Phe Val Gln Asp Glu
    130                 135                 140                 
Ala Glu Asp Ser Gly Asn Asp Phe Leu Ser Ser Glu Ser Thr Asp Ser
145                 150                 155                 160 
Ser Ile Pro Trp Phe Leu Arg Val Gln Glu Leu Ala His Asp Ser Leu
                165                 170                 175     
Ile Ala Ala Thr Arg Ala Gln Leu Ala Lys Asn Ala Lys Thr Ser Ser
            180                 185                 190         
Asn Gly Glu Asn Val His Leu Gly Ser Gly Asp Gly Gln Ser Lys Asp
        195                 200                 205             
Ser Gly Pro Leu Pro Gln Val Glu Lys Lys Leu Lys Cys Thr Val Glu
    210                 215                 220                 
Gly Cys Asp Arg Thr Phe Val Trp Pro Ala His Phe Lys Tyr His Leu
225                 230                 235                 240 
Lys Thr His Arg Asn Asp Arg Ser Phe Ile Cys Pro Ala Glu Gly Cys
                245                 250                 255     
Gly Lys Ser Phe Tyr Val Leu Gln Arg Leu Lys Val His Met Arg Thr
            260                 265                 270         
His Asn Gly Glu Lys Pro Phe Met Cys His Glu Ser Gly Cys Gly Lys
        275                 280                 285             
Gln Phe Thr Thr Ala Gly Asn Leu Lys Asn His Arg Arg Ile His Thr
    290                 295                 300                 
Gly Glu Lys Pro Phe Leu Cys Glu Ala Gln Gly Cys Gly Arg Ser Phe
305                 310                 315                 320 
Ala Glu Tyr Ser Ser Leu Arg Lys His Leu Val Val His Ser Gly Glu
                325                 330                 335     
Lys Pro His Gln Cys Gln Val Cys Gly Lys Thr Phe Ser Gln Ser Gly
            340                 345                 350         
Ser Arg Asn Val His Met Arg Lys His His Leu Gln Leu Gly Ala Ala
        355                 360                 365             
Gly Ser Gln Glu Gln Glu Gln Thr Glu Val Leu Ala Glu Gly Ser Pro
    370                 375                 380                 
Arg Ser Leu Ser Ser Val Pro Asp Val Thr His His Leu Val Thr Met
385                 390                 395                 400 
Gln Ser Gly Arg Gln Ser Tyr Glu Val Ser Val Leu Thr Ala Val Asn
                405                 410                 415     
Pro Gln Glu Leu Leu Asn Gln Gly Asp Leu Thr Glu Arg Arg Thr
            420                 425                 430     


<210> 7393
<211> 272
<212> PRT
<213> Homo sapiens

<400> 7393
Met Leu Ser Asp Glu Leu Glu Ser Lys Pro Glu Leu Leu Val Gln Phe
 1               5                  10                  15      
Val Gln Asn Thr Ser Ile Pro Leu Gly Gln Gly Leu Val Glu Ser Glu
            20                  25                  30          
Ala Lys Asp Ile Thr Cys Leu Ser Leu Leu Pro Val Thr Glu Ala Ser
        35                  40                  45              
Glu Cys Ser Arg Leu Met Leu Pro Asp Asp Thr Thr Asn His Ser Asn
    50                  55                  60                  
Ser Ser Lys Glu Val Pro Ser Ser Ala Val Leu Arg Ser Leu Arg Val
65                  70                  75                  80  
Asn Val Gly Pro Asp Gly Glu Glu Thr Arg Ala Gln Thr Val Gln Lys
                85                  90                  95      
Ser Pro Glu Phe Leu Ser Thr Ser Glu Ser Ser Ser Leu Leu Gln Asp
            100                 105                 110         
Leu Gln Pro Ser Asp Ser Thr Ser Phe Ile Leu Leu Asn Leu Thr Arg
        115                 120                 125             
Ala Gly Leu Gly Ser Ser Ala Glu His Leu Val Phe Val Gln Asp Glu
    130                 135                 140                 
Ala Glu Asp Ser Gly Asn Asp Phe Leu Ser Ser Glu Ser Thr Asp Ser
145                 150                 155                 160 
Ser Ile Pro Trp Phe Leu Arg Val Gln Glu Leu Ala His Asp Ser Leu
                165                 170                 175     
Ile Ala Ala Thr Arg Ala Gln Leu Ala Lys Asn Ala Lys Thr Ser Ser
            180                 185                 190         
Asn Gly Glu Asn Val His Leu Gly Ser Gly Asp Gly Gln Ser Lys Asp
        195                 200                 205             
Ser Gly Pro Leu Pro Gln Val Glu Lys Lys Leu Lys Cys Thr Val Glu
    210                 215                 220                 
Gly Cys Asp Arg Thr Phe Val Trp Pro Ala His Phe Lys Tyr His Leu
225                 230                 235                 240 
Lys Thr His Arg Arg Leu Trp Glu Lys Leu Leu Cys Ala Ala Glu Ala
                245                 250                 255     
Glu Gly Ala His Glu Asp Pro Gln Trp Arg Glu Ala Leu Tyr Val Pro
            260                 265                 270         


<210> 7394
<211> 478
<212> PRT
<213> Homo sapiens

<400> 7394
Met Leu Ser Asp Glu Leu Glu Ser Lys Pro Glu Leu Leu Val Gln Phe
 1               5                  10                  15      
Val Gln Asn Thr Ser Ile Pro Leu Gly Gln Gly Leu Val Glu Ser Glu
            20                  25                  30          
Ala Lys Asp Ile Thr Cys Leu Ser Leu Leu Pro Val Thr Glu Ala Ser
        35                  40                  45              
Glu Cys Ser Arg Leu Met Leu Pro Asp Asp Thr Thr Asn His Ser Asn
    50                  55                  60                  
Ser Ser Lys Glu Val Pro Ser Ser Ala Val Leu Arg Ser Leu Arg Val
65                  70                  75                  80  
Asn Val Gly Pro Asp Gly Glu Glu Thr Arg Ala Gln Thr Val Gln Lys
                85                  90                  95      
Ser Pro Glu Phe Leu Ser Thr Ser Glu Ser Ser Ser Leu Leu Gln Asp
            100                 105                 110         
Leu Gln Pro Ser Asp Ser Thr Ser Phe Ile Leu Leu Asn Leu Thr Arg
        115                 120                 125             
Ala Gly Leu Gly Ser Ser Ala Glu His Leu Val Phe Val Gln Asp Glu
    130                 135                 140                 
Ala Glu Asp Ser Gly Asn Asp Phe Leu Ser Ser Glu Ser Thr Asp Ser
145                 150                 155                 160 
Ser Ile Pro Trp Phe Leu Arg Val Gln Glu Leu Ala His Asp Ser Leu
                165                 170                 175     
Ile Ala Ala Thr Arg Ala Gln Leu Ala Lys Asn Ala Lys Thr Ser Ser
            180                 185                 190         
Asn Gly Glu Asn Val His Leu Gly Ser Gly Asp Gly Gln Ser Lys Asp
        195                 200                 205             
Ser Gly Pro Leu Pro Gln Val Glu Lys Lys Leu Lys Cys Thr Val Glu
    210                 215                 220                 
Gly Cys Asp Arg Thr Phe Val Trp Pro Ala His Phe Lys Tyr His Leu
225                 230                 235                 240 
Lys Thr His Arg Asn Asp Arg Ser Phe Ile Cys Pro Ala Glu Gly Cys
                245                 250                 255     
Gly Lys Ser Phe Tyr Val Leu Gln Arg Leu Lys Val His Met Arg Thr
            260                 265                 270         
His Asn Gly Glu Lys Pro Phe Met Cys His Glu Ser Gly Cys Gly Lys
        275                 280                 285             
Gln Phe Thr Thr Ala Gly Asn Leu Lys Asn His Arg Arg Ile His Thr
    290                 295                 300                 
Gly Glu Lys Pro Phe Leu Cys Glu Ala Gln Gly Cys Gly Arg Ser Phe
305                 310                 315                 320 
Ala Glu Tyr Ser Ser Leu Arg Lys His Leu Val Val His Ser Gly Glu
                325                 330                 335     
Lys Pro His Gln Cys Gln Val Cys Gly Lys Thr Phe Ser Gln Ser Gly
            340                 345                 350         
Ser Arg Asn Val His Met Arg Lys His His Leu Gln Leu Gly Ala Ala
        355                 360                 365             
Gly Ser Gln Glu Gln Glu Gln Thr Ala Glu Pro Leu Met Gly Ser Ser
    370                 375                 380                 
Leu Leu Glu Glu Ala Ser Val Pro Ser Lys Asn Leu Val Ser Met Asn
385                 390                 395                 400 
Ser Gln Pro Ser Leu Gly Gly Glu Ser Leu Asn Leu Pro Asn Thr Asn
                405                 410                 415     
Ser Ile Leu Gly Val Asp Asp Glu Val Leu Ala Glu Gly Ser Pro Arg
            420                 425                 430         
Ser Leu Ser Ser Val Pro Asp Val Thr His His Leu Val Thr Met Gln
        435                 440                 445             
Ser Gly Arg Gln Ser Tyr Glu Val Ser Val Leu Thr Ala Val Asn Pro
    450                 455                 460                 
Gln Glu Leu Leu Asn Gln Gly Asp Leu Thr Glu Arg Arg Thr
465                 470                 475             


<210> 7395
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 7395
Met Ile Ala Val Ser Thr Ala Asn Gly Tyr Ile Leu Phe Phe His Ile
 1               5                  10                  15      
Thr Ser Thr Arg Gly Asp Lys Tyr Leu Tyr Glu Pro Val Tyr Pro Lys
            20                  25                  30          
Gly Ser Pro Gln Met Lys Gly Thr Pro His Phe Lys Glu Glu Gln Cys
        35                  40                  45              
Ala Pro Ala Leu Asn Leu Glu Met Arg Lys Ile Leu Asp Leu Gln Ala
    50                  55                  60                  
Pro Ile Met Ser Leu Gln Ser Val Leu Glu Asp Leu Leu Val Ala Thr
65                  70                  75                  80  
Ser Asp Gly Leu Leu His Leu Ile His Trp Glu Gly Met Thr Asn Gly
                85                  90                  95      
Arg Lys Ala Ile Asn Leu Cys Thr Val Pro Phe Ser Val Asp Leu Gln
            100                 105                 110         
Ser Ser Arg Val Gly Ser Phe Leu Gly Phe Thr Asp Val His Ile Arg
        115                 120                 125             
Asp Met Glu Tyr Cys Ala Thr Leu Asp Gly Phe Ala Val Val Phe Asn
    130                 135                 140                 
Asp Gly Lys Val Gly Phe Ile Thr Pro Val Ser Ser Arg Phe Thr Ala
145                 150                 155                 160 
Glu Gln Leu His Gly Val Trp Pro Gln Asp Val Val Asp Gly Thr Cys
                165                 170                 175     
Val Ala Val Asn Asn Lys Tyr Arg Leu Met Ala Phe Gly Cys Val Ser
            180                 185                 190         
Gly Ser Val Gln Val Tyr Thr Ile Asp Asn Ser Thr Gly Ala Met Leu
        195                 200                 205             
Leu Ser His Lys Leu Glu Leu Thr Ala Lys Gln Tyr Pro Asp Ile Trp
    210                 215                 220                 
Asn Lys Thr Gly Ala Val Lys Leu Met Arg Trp Ser Pro Asp Asn Ser
225                 230                 235                 240 
Val Val Ile Val Thr Trp Glu Tyr Gly Gly Leu Ser Leu Trp Ser Val
                245                 250                 255     
Phe Gly Ala Gln Leu Ile Cys Thr Leu Gly Gly Asp Phe Ala Tyr Arg
            260                 265                 270         
Ser Asp Gly Thr Lys Lys Asp Pro Leu Lys Ile Asn Ser Met Ser Trp
        275                 280                 285             
Gly Ala Glu Gly Tyr His Leu Trp Val Ile Ser Gly Phe Gly Ser Gln
    290                 295                 300                 
Asn Thr Glu Ile Glu Ser Asp Leu Arg Ser Val Val Lys Gln Pro Ser
305                 310                 315                 320 
Ile Leu Leu Phe Gln Phe Ile Lys Ser Val Leu Thr Val Asn Pro Cys
                325                 330                 335     
Met Ser Asn Gln Glu Gln Val Leu Leu Gln Gly Glu Asp Arg Leu Tyr
            340                 345                 350         
Leu Asn Cys Gly Glu Ala Ser Gln Thr Gln Asn Pro Arg Ser Ser Ser
        355                 360                 365             
Thr His Ser Glu His Lys Pro Ser Arg Glu Lys Ser Pro Phe Ala Asp
    370                 375                 380                 
Gly Gly Leu Glu Ser Gln Gly Leu Ser Thr Leu Leu Gly His Arg His
385                 390                 395                 400 
Trp His Val Val Gln Ile Ser Ser Thr Tyr Leu Glu Ser Asn Trp Pro
                405                 410                 415     
Ile Arg Phe Ser Ala Ile Asp Lys Leu Gly Gln Asn Ile Ala Val Val
            420                 425                 430         
Gly Lys Phe Gly Phe Ala His Tyr Ser Leu Leu Thr Lys Lys Trp Lys
        435                 440                 445             
Leu Phe Gly Asn Ile Thr Gln Glu Gln Asn Met Ile Val Thr Gly Gly
    450                 455                 460                 
Leu Ala Trp Trp Asn Asp Phe Met Val Leu Ala Cys Tyr Asn Ile Asn
465                 470                 475                 480 
Asp Arg Gln Glu Glu Leu Arg Val Tyr Leu Arg Thr Ser Asn Leu Asp
                485                 490                 495     
Asn Ala Phe Ala His Val Thr Lys Ala Gln Ala Glu Thr Leu Leu Leu
            500                 505                 510         
Ser Val Phe Gln Asp Met Val Ile Val Phe Arg Ala Asp Cys Ser Ile
        515                 520                 525             
Cys Leu Tyr Ser Ile Glu Arg Lys Ser Asp Gly Pro Asn Thr Thr Ala
    530                 535                 540                 
Gly Ile Gln Val Leu Gln Glu Val Ser Met Ser Arg Tyr Ile Pro His
545                 550                 555                 560 
Pro Phe Leu Val Val Ser Val Thr Leu Thr Ser Val Ser Thr Glu Asn
                565                 570                 575     
Gly Ile Thr Leu Lys Met Pro Gln Gln Ala Arg Gly Ala Glu Ser Ile
            580                 585                 590         
Met Leu Asn Leu Ala Gly Gln Leu Ile Met Met Gln Arg Asp Arg Ser
        595                 600                 605             
Gly Pro Gln Ile Arg Glu Lys Asp Ser Asn Pro Asn Asn Gln Arg Lys
    610                 615                 620                 
Leu Leu Pro Phe Cys Pro Pro Val Val Leu Ala Gln Ser Val Glu Asn
625                 630                 635                 640 
Val Trp Thr Thr Cys Arg Ala Asn Lys Gln Lys Arg His Leu Leu Glu
                645                 650                 655     
Ala Leu Trp Leu Ser Cys Gly Gly Ala Gly Met Lys Val Trp Leu Pro
            660                 665                 670         
Leu Phe Pro Arg Asp His Arg Lys Pro His Ser Phe Leu Ser Gln Arg
        675                 680                 685             
Ile Met Leu Pro Phe His Ile Asn Ile Tyr Pro Leu Ala Val Leu Phe
    690                 695                 700                 
Glu Asp Ala Leu Val Leu Gly Ala Val Asn Asp Thr Leu Leu Tyr Asp
705                 710                 715                 720 
Ser Leu Tyr Thr Arg Asn Asn Ala Arg Glu Gln Leu Glu Val Leu Phe
                725                 730                 735     
Pro Phe Cys Val Val Glu Arg Thr Ser Gln Ile Tyr Leu His His Ile
            740                 745                 750         
Leu Arg Gln Leu Leu Val Arg Asn Leu Gly Glu Gln Ala Leu Leu Leu
        755                 760                 765             
Ala Gln Ser Cys Ala Thr Leu Pro Tyr Phe Pro His Val Leu Glu Leu
    770                 775                 780                 
Met Leu His Glu Val Leu Glu Glu Glu Ala Thr Ser Arg Glu Pro Ile
785                 790                 795                 800 
Pro Asp Pro Leu Leu Pro Thr Val Ala Lys Phe Ile Thr Glu Phe Pro
                805                 810                 815     
Leu Phe Leu Gln Thr Val Val His Cys Ala Arg Lys Thr Glu Tyr Ala
            820                 825                 830         
Leu Trp Asn Tyr Leu Phe Ala Ala Val Gly Asn Pro Lys Asp Leu Phe
        835                 840                 845             
Glu Glu Cys Leu Met Ala Gln Asp Leu Asp Thr Ala Ala Ser Tyr Leu
    850                 855                 860                 
Ile Ile Leu Gln Asn Met Glu Val Pro Ala Val Ser Arg Gln His Ala
865                 870                 875                 880 
Thr Leu Leu Phe Asn Thr Ala Leu Glu Gln Gly Lys Trp Asp Leu Cys
                885                 890                 895     
Arg His Met Ile Arg Phe Leu Lys Ala Ile Gly Ser Gly Glu Ser Glu
            900                 905                 910         
Thr Pro Pro Ser Thr Pro Thr Ala Gln Glu Pro Ser Ser Ser Gly Gly
        915                 920                 925             
Phe Glu Phe Phe Arg Asn Arg Ser Ile Ser Leu Ser Gln Ser Ala Glu
    930                 935                 940                 
Asn Val Pro Ala Ser Lys Phe Ser Leu Gln Lys Thr Leu Ser Met Pro
945                 950                 955                 960 
Ser Gly Pro Ser Gly Lys Arg Trp Ser Lys Asp Ser Asp Cys Ala Glu
                965                 970                 975     
Asn Met Tyr Ile Asp Met Met Leu Trp Arg His Ala Arg Arg Leu Leu
            980                 985                 990         
Glu Asp Val Arg Leu Lys Asp Leu Gly Cys Phe Ala Ala Gln Leu Gly
        995                 1000                1005            
Phe Glu Leu Ile Ser Trp Leu Cys Lys Glu Arg Thr Arg Ala Ala Arg
    1010                1015                1020                
Val Asp Asn Phe Val Ile Ala Leu Lys Arg Leu His Lys Asp Phe Leu
1025                1030                1035                1040
Trp Pro Leu Pro Ile Ile Pro Ala Ser Ser Ile Ser Ser Pro Phe Lys
                1045                1050                1055    
Asn Gly Lys Tyr Arg Thr Gly Asn Val Asp Phe Met Ser Leu Val Gln
            1060                1065                1070        
Gly Glu Leu Tyr Phe Thr Pro Cys Ile Tyr Thr Phe Cys Tyr
        1075                1080                1085    


<210> 7396
<211> 794
<212> PRT
<213> Homo sapiens

<400> 7396
Met Gly Ser Thr Asp Ser Lys Leu Asn Phe Arg Lys Ala Val Ile Gln
 1               5                  10                  15      
Leu Thr Thr Lys Thr Gln Pro Val Glu Ala Thr Asp Asp Ala Phe Trp
            20                  25                  30          
Asp Gln Phe Trp Ala Asp Thr Ala Thr Ser Val Gln Asp Val Phe Ala
        35                  40                  45              
Leu Val Pro Ala Ala Glu Ile Arg Ala Val Arg Glu Glu Ser Pro Ser
    50                  55                  60                  
Asn Leu Ala Thr Leu Cys Tyr Lys Ala Val Glu Lys Leu Val Gln Gly
65                  70                  75                  80  
Ala Glu Ser Gly Cys His Ser Glu Lys Glu Lys Gln Ile Val Leu Asn
                85                  90                  95      
Cys Ser Arg Leu Leu Thr Arg Val Leu Pro Tyr Ile Phe Glu Asp Pro
            100                 105                 110         
Asp Trp Arg Gly Phe Phe Trp Ser Thr Val Pro Gly Ala Gly Arg Gly
        115                 120                 125             
Gly Gln Gly Glu Glu Asp Asp Glu His Ala Arg Pro Leu Ala Glu Ser
    130                 135                 140                 
Leu Leu Leu Ala Ile Ala Asp Leu Leu Phe Cys Pro Asp Phe Thr Val
145                 150                 155                 160 
Gln Ser His Arg Arg Ser Thr Val Asp Ser Ala Glu Asp Val His Ser
                165                 170                 175     
Leu Asp Ser Cys Glu Tyr Ile Trp Glu Ala Gly Val Gly Phe Ala His
            180                 185                 190         
Ser Pro Gln Pro Asn Tyr Ile His Asp Met Asn Arg Met Glu Leu Leu
        195                 200                 205             
Lys Leu Leu Leu Thr Cys Phe Ser Glu Ala Met Tyr Leu Pro Pro Ala
    210                 215                 220                 
Pro Glu Ser Gly Ser Thr Asn Pro Trp Val Gln Phe Phe Cys Ser Thr
225                 230                 235                 240 
Glu Asn Arg His Ala Leu Pro Leu Phe Thr Ser Leu Leu Asn Thr Val
                245                 250                 255     
Cys Ala Tyr Asp Pro Val Gly Tyr Gly Ile Pro Tyr Asn His Leu Leu
            260                 265                 270         
Phe Ser Asp Tyr Arg Glu Pro Leu Val Glu Glu Ala Ala Gln Val Leu
        275                 280                 285             
Ile Val Thr Leu Asp His Asp Ser Ala Ser Ser Ala Ser Pro Thr Val
    290                 295                 300                 
Asp Gly Thr Thr Thr Gly Thr Ala Met Asp Asp Ala Asp Pro Pro Gly
305                 310                 315                 320 
Pro Glu Asn Leu Phe Val Asn Tyr Leu Ser Arg Ile His Arg Pro Leu
                325                 330                 335     
Leu Cys Pro Arg Pro Gln Asp Phe Gln Phe Ile Leu Lys Gly Ile Ala
            340                 345                 350         
Arg Leu Leu Ser Asn Pro Leu Leu Gln Thr Tyr Leu Pro Asn Ser Thr
        355                 360                 365             
Lys Lys Ile Gln Phe His Gln Glu Leu Leu Val Leu Phe Trp Lys Leu
    370                 375                 380                 
Cys Asp Phe Asn Lys Lys Phe Leu Phe Phe Val Leu Lys Ser Ser Asp
385                 390                 395                 400 
Val Leu Asp Ile Leu Val Pro Ile Leu Phe Phe Leu Asn Asp Ala Arg
                405                 410                 415     
Ala Asp Gln Ser Arg Val Gly Leu Met His Ile Gly Val Phe Ile Leu
            420                 425                 430         
Leu Leu Leu Ser Gly Glu Arg Asn Phe Gly Val Arg Leu Asn Lys Pro
        435                 440                 445             
Tyr Ser Ile Arg Val Pro Met Asp Ile Pro Val Phe Thr Gly Thr His
    450                 455                 460                 
Ala Asp Leu Leu Ile Val Val Phe His Lys Ile Ile Thr Ser Gly His
465                 470                 475                 480 
Gln Arg Leu Gln Pro Leu Phe Asp Cys Leu Leu Thr Ile Val Val Asn
                485                 490                 495     
Val Ser Pro Tyr Leu Lys Ser Leu Ser Met Val Thr Ala Asn Lys Leu
            500                 505                 510         
Leu His Leu Leu Glu Ala Phe Ser Thr Thr Trp Phe Leu Phe Ser Ala
        515                 520                 525             
Ala Gln Asn His His Leu Val Phe Phe Leu Leu Glu Val Phe Asn Asn
    530                 535                 540                 
Ile Ile Gln Tyr Gln Phe Asp Gly Asn Ser Asn Leu Val Tyr Ala Ile
545                 550                 555                 560 
Ile Arg Lys Arg Ser Ile Phe His Gln Leu Ala Asn Leu Pro Thr Asp
                565                 570                 575     
Pro Pro Thr Ile His Lys Ala Leu Gln Arg Arg Arg Arg Thr Pro Glu
            580                 585                 590         
Pro Leu Ser Arg Thr Gly Ser Gln Glu Gly Thr Ser Met Glu Gly Ser
        595                 600                 605             
Arg Pro Ala Ala Pro Ala Glu Pro Gly Thr Leu Lys Thr Ser Leu Val
    610                 615                 620                 
Ala Thr Pro Gly Ile Asp Lys Leu Thr Glu Lys Ser Gln Val Ser Glu
625                 630                 635                 640 
Asp Gly Thr Leu Arg Ser Leu Glu Pro Glu Pro Gln Gln Ser Leu Glu
                645                 650                 655     
Asp Gly Ser Pro Ala Lys Gly Glu Pro Ser Gln Ala Trp Arg Glu Gln
            660                 665                 670         
Arg Arg Pro Ser Thr Ser Ser Ala Ser Gly Gln Trp Ser Pro Thr Pro
        675                 680                 685             
Glu Trp Val Leu Ser Trp Lys Ser Lys Leu Pro Leu Gln Thr Ile Met
    690                 695                 700                 
Arg Leu Leu Gln Val Leu Val Pro Gln Val Glu Lys Ile Cys Ile Asp
705                 710                 715                 720 
Lys Gly Leu Thr Asp Glu Ser Glu Ile Leu Arg Phe Leu Gln His Gly
                725                 730                 735     
Thr Leu Val Gly Leu Leu Pro Val Pro His Pro Ile Leu Ile Arg Lys
            740                 745                 750         
Tyr Gln Ala Asn Ser Gly Thr Ala Met Trp Phe Arg Thr Tyr Met Trp
        755                 760                 765             
Gly Val Ile Tyr Leu Arg Asn Val Asp Pro Pro Val Trp Tyr Asp Thr
    770                 775                 780                 
Asp Val Lys Leu Phe Glu Ile Gln Arg Val
785                 790                 


<210> 7397
<211> 626
<212> PRT
<213> Homo sapiens

<400> 7397
Met Gly Ser Thr Asp Ser Lys Leu Asn Phe Arg Lys Ala Val Ile Gln
 1               5                  10                  15      
Leu Thr Thr Lys Thr Gln Pro Val Glu Ala Thr Asp Asp Ala Phe Trp
            20                  25                  30          
Asp Gln Phe Trp Ala Asp Thr Ala Thr Ser Val Gln Asp Val Phe Ala
        35                  40                  45              
Leu Val Pro Ala Ala Glu Ile Arg Ala Val Arg Glu Glu Ser Pro Ser
    50                  55                  60                  
Asn Leu Ala Thr Leu Cys Tyr Lys Ala Val Glu Lys Leu Val Gln Gly
65                  70                  75                  80  
Ala Glu Ser Gly Cys His Ser Glu Lys Glu Lys Gln Ile Val Leu Asn
                85                  90                  95      
Cys Ser Arg Leu Leu Thr Arg Val Leu Pro Tyr Ile Phe Glu Asp Pro
            100                 105                 110         
Asp Trp Arg Gly Phe Phe Trp Ser Thr Val Pro Gly Ala Gly Arg Gly
        115                 120                 125             
Gly Gln Gly Glu Glu Asp Asp Glu His Ala Arg Pro Leu Ala Glu Ser
    130                 135                 140                 
Leu Leu Leu Ala Ile Ala Asp Leu Leu Phe Cys Pro Asp Phe Thr Val
145                 150                 155                 160 
Gln Ser His Arg Arg Ser Thr Val Asp Ser Ala Glu Asp Val His Ser
                165                 170                 175     
Leu Asp Ser Cys Glu Tyr Ile Trp Glu Ala Gly Val Gly Phe Ala His
            180                 185                 190         
Ser Pro Gln Pro Asn Tyr Ile His Asp Met Asn Arg Met Glu Leu Leu
        195                 200                 205             
Lys Leu Leu Leu Thr Cys Phe Ser Glu Ala Met Tyr Leu Pro Pro Ala
    210                 215                 220                 
Pro Glu Ser Gly Ser Thr Asn Pro Trp Val Gln Phe Phe Cys Ser Thr
225                 230                 235                 240 
Glu Asn Arg His Ala Leu Pro Leu Phe Thr Ser Leu Leu Asn Thr Val
                245                 250                 255     
Cys Ala Tyr Asp Pro Val Gly Tyr Gly Ile Pro Tyr Asn His Leu Leu
            260                 265                 270         
Phe Ser Asp Tyr Arg Glu Pro Leu Val Glu Glu Ala Ala Gln Val Leu
        275                 280                 285             
Ile Val Thr Leu Asp His Asp Ser Ala Ser Ser Ala Ser Pro Thr Val
    290                 295                 300                 
Asp Gly Thr Thr Thr Gly Thr Ala Met Asp Asp Ala Asp Pro Pro Gly
305                 310                 315                 320 
Pro Glu Asn Leu Phe Val Asn Tyr Leu Ser Arg Ile His Arg Pro Leu
                325                 330                 335     
Leu Cys Pro Arg Pro Gln Asp Phe Gln Phe Ile Leu Lys Gly Ile Ala
            340                 345                 350         
Arg Leu Leu Ser Asn Pro Leu Leu Gln Thr Tyr Leu Pro Asn Ser Thr
        355                 360                 365             
Lys Lys Ile Gln Phe His Gln Glu Leu Leu Val Leu Phe Trp Lys Leu
    370                 375                 380                 
Cys Asp Phe Asn Lys Lys Phe Leu Phe Phe Val Leu Lys Ser Ser Asp
385                 390                 395                 400 
Val Leu Asp Ile Leu Val Pro Ile Leu Phe Phe Leu Asn Asp Ala Arg
                405                 410                 415     
Ala Asp Gln Ser Arg Val Gly Leu Met His Ile Gly Val Phe Ile Leu
            420                 425                 430         
Leu Leu Leu Ser Gly Glu Arg Asn Phe Gly Val Arg Leu Asn Lys Pro
        435                 440                 445             
Tyr Ser Ile Arg Val Pro Met Asp Ile Pro Val Phe Thr Gly Thr His
    450                 455                 460                 
Ala Asp Leu Leu Ile Val Val Phe His Lys Ile Ile Thr Ser Gly His
465                 470                 475                 480 
Gln Arg Leu Gln Pro Leu Phe Asp Cys Leu Leu Thr Ile Val Val Asn
                485                 490                 495     
Val Ser Pro Tyr Leu Lys Ser Leu Ser Met Val Thr Ala Asn Lys Leu
            500                 505                 510         
Leu His Leu Leu Glu Ala Phe Ser Thr Thr Trp Phe Leu Phe Ser Ala
        515                 520                 525             
Ala Gln Asn His His Leu Val Phe Phe Leu Leu Glu Val Phe Asn Asn
    530                 535                 540                 
Ile Ile Gln Tyr Gln Phe Asp Gly Asn Ser Asn Leu Val Tyr Ala Ile
545                 550                 555                 560 
Ile Arg Lys Arg Ser Ile Phe His Gln Leu Ala Asn Leu Pro Thr Asp
                565                 570                 575     
Pro Pro Thr Ile His Lys Ala Leu Gln Arg Arg Arg Arg Thr Pro Glu
            580                 585                 590         
Pro Leu Ser Arg Thr Gly Arg Arg Ala Pro Pro Trp Arg Ala Pro Ala
        595                 600                 605             
Pro Leu Pro Leu Gln Ser Gln Ala Pro Ser Arg Pro Val Trp Trp Leu
    610                 615                 620                 
Leu Gln
625     


<210> 7398
<211> 572
<212> PRT
<213> Homo sapiens

<400> 7398
Met Gly Ser Thr Asp Ser Lys Leu Asn Phe Arg Lys Ala Val Ile Gln
 1               5                  10                  15      
Leu Thr Thr Lys Thr His Ala Leu Pro Leu Phe Thr Ser Leu Leu Asn
            20                  25                  30          
Thr Val Cys Ala Tyr Asp Pro Val Gly Tyr Gly Ile Pro Tyr Asn His
        35                  40                  45              
Leu Leu Phe Ser Asp Tyr Arg Glu Pro Leu Val Glu Glu Ala Ala Gln
    50                  55                  60                  
Val Leu Ile Val Thr Leu Asp His Asp Ser Ala Ser Ser Ala Ser Pro
65                  70                  75                  80  
Thr Val Asp Gly Thr Thr Thr Gly Thr Ala Met Asp Asp Ala Asp Pro
                85                  90                  95      
Pro Gly Pro Glu Asn Leu Phe Val Asn Tyr Leu Ser Arg Ile His Arg
            100                 105                 110         
Pro Leu Leu Cys Pro Arg Pro Gln Asp Phe Gln Phe Ile Leu Lys Gly
        115                 120                 125             
Ile Ala Arg Leu Leu Ser Asn Pro Leu Leu Gln Thr Tyr Leu Pro Asn
    130                 135                 140                 
Ser Thr Lys Lys Ile Gln Phe His Gln Glu Leu Leu Val Leu Phe Trp
145                 150                 155                 160 
Lys Leu Cys Asp Phe Asn Lys Lys Phe Leu Phe Phe Val Leu Lys Ser
                165                 170                 175     
Ser Asp Val Leu Asp Ile Leu Val Pro Ile Leu Phe Phe Leu Asn Asp
            180                 185                 190         
Ala Arg Ala Asp Gln Ser Arg Val Gly Leu Met His Ile Gly Val Phe
        195                 200                 205             
Ile Leu Leu Leu Leu Ser Gly Glu Arg Asn Phe Gly Val Arg Leu Asn
    210                 215                 220                 
Lys Pro Tyr Ser Ile Arg Val Pro Met Asp Ile Pro Val Phe Thr Gly
225                 230                 235                 240 
Thr His Ala Asp Leu Leu Ile Val Val Phe His Lys Ile Ile Thr Ser
                245                 250                 255     
Gly His Gln Arg Leu Gln Pro Leu Phe Asp Cys Leu Leu Thr Ile Val
            260                 265                 270         
Val Asn Val Ser Pro Tyr Leu Lys Ser Leu Ser Met Val Thr Ala Asn
        275                 280                 285             
Lys Leu Leu His Leu Leu Glu Ala Phe Ser Thr Thr Trp Phe Leu Phe
    290                 295                 300                 
Ser Ala Ala Gln Asn His His Leu Val Phe Phe Leu Leu Glu Val Phe
305                 310                 315                 320 
Asn Asn Ile Ile Gln Tyr Gln Phe Asp Gly Asn Ser Asn Leu Val Tyr
                325                 330                 335     
Ala Ile Ile Arg Lys Arg Ser Ile Phe His Gln Leu Ala Asn Leu Pro
            340                 345                 350         
Thr Asp Pro Pro Thr Ile His Lys Ala Leu Gln Arg Arg Arg Arg Thr
        355                 360                 365             
Pro Glu Pro Leu Ser Arg Thr Gly Ser Gln Glu Gly Thr Ser Met Glu
    370                 375                 380                 
Gly Ser Arg Pro Ala Ala Pro Ala Glu Pro Gly Thr Leu Lys Thr Ser
385                 390                 395                 400 
Leu Val Ala Thr Pro Gly Ile Asp Lys Leu Thr Glu Lys Ser Gln Val
                405                 410                 415     
Ser Glu Asp Gly Thr Leu Arg Ser Leu Glu Pro Glu Pro Gln Gln Ser
            420                 425                 430         
Leu Glu Asp Gly Ser Pro Ala Lys Gly Glu Pro Ser Gln Ala Trp Arg
        435                 440                 445             
Glu Gln Arg Arg Pro Ser Thr Ser Ser Ala Ser Gly Gln Trp Ser Pro
    450                 455                 460                 
Thr Pro Glu Trp Val Leu Ser Trp Lys Ser Lys Leu Pro Leu Gln Thr
465                 470                 475                 480 
Ile Met Arg Leu Leu Gln Val Leu Val Pro Gln Val Glu Lys Ile Cys
                485                 490                 495     
Ile Asp Lys Gly Leu Thr Asp Glu Ser Glu Ile Leu Arg Phe Leu Gln
            500                 505                 510         
His Gly Thr Leu Val Gly Leu Leu Pro Val Pro His Pro Ile Leu Ile
        515                 520                 525             
Arg Lys Tyr Gln Ala Asn Ser Gly Thr Ala Met Trp Phe Arg Thr Tyr
    530                 535                 540                 
Met Trp Gly Val Ile Tyr Leu Arg Asn Val Asp Pro Pro Val Trp Tyr
545                 550                 555                 560 
Asp Thr Asp Val Lys Leu Phe Glu Ile Gln Arg Val
                565                 570         


<210> 7399
<211> 234
<212> PRT
<213> Homo sapiens

<400> 7399
Met Ser Val Lys Glu Gly Ala Gln Arg Lys Trp Ala Ala Leu Lys Glu
 1               5                  10                  15      
Lys Leu Gly Pro Gln Asp Ser Asp Pro Thr Glu Ala Asn Leu Glu Ser
            20                  25                  30          
Ala Asp Pro Glu Leu Cys Ile Arg Leu Leu Gln Met Pro Ser Val Val
        35                  40                  45              
Asn Tyr Ser Gly Leu Arg Lys Arg Leu Glu Gly Ser Asp Gly Gly Trp
    50                  55                  60                  
Met Val Gln Phe Leu Glu Gln Ser Gly Leu Asp Leu Leu Leu Glu Ala
65                  70                  75                  80  
Leu Ala Arg Leu Ser Gly Arg Gly Val Ala Arg Ile Ser Asp Ala Leu
                85                  90                  95      
Leu Gln Leu Thr Cys Val Ser Cys Val Arg Ala Val Met Asn Ser Arg
            100                 105                 110         
Gln Gly Ile Glu Tyr Ile Leu Ser Asn Gln Gly Tyr Val Arg Gln Leu
        115                 120                 125             
Ser Gln Ala Leu Asp Thr Ser Asn Val Met Val Lys Lys Gln Val Phe
    130                 135                 140                 
Glu Leu Leu Ala Ala Leu Cys Ile Tyr Ser Pro Glu Gly His Val Leu
145                 150                 155                 160 
Thr Leu Asp Ala Leu Asp His Tyr Lys Thr Val Cys Ser Gln Gln Tyr
                165                 170                 175     
Arg Phe Ser Ile Val Met Asn Glu Leu Ser Gly Ser Asp Asn Val Pro
            180                 185                 190         
Tyr Val Val Thr Leu Leu Ser Val Ile Asn Ala Val Ile Leu Gly Pro
        195                 200                 205             
Glu Asp Leu Arg Ala Arg Thr Gln Leu Arg Asn Glu Phe Ile Gly Leu
    210                 215                 220                 
Gln Leu Leu Asp Val Leu Ala Arg Leu Arg
225                 230                 


<210> 7400
<211> 418
<212> PRT
<213> Homo sapiens

<400> 7400
Met Glu Thr His Ile Ser Cys Leu Phe Pro Glu Leu Leu Ala Met Ile
 1               5                  10                  15      
Phe Gly Tyr Leu Asp Val Arg Asp Lys Gly Arg Ala Ala Gln Val Cys
            20                  25                  30          
Thr Ala Trp Arg Asp Ala Ala Tyr His Lys Ser Val Trp Arg Gly Val
        35                  40                  45              
Glu Ala Lys Leu His Leu Arg Arg Ala Asn Pro Ser Leu Phe Pro Ser
    50                  55                  60                  
Leu Gln Ala Arg Gly Ile Arg Arg Val Gln Ile Leu Ser Leu Arg Arg
65                  70                  75                  80  
Ser Leu Ser Tyr Val Ile Gln Gly Met Ala Asn Ile Glu Ser Leu Asn
                85                  90                  95      
Leu Ser Gly Cys Tyr Asn Leu Thr Asp Asn Gly Leu Gly His Ala Phe
            100                 105                 110         
Val Gln Glu Ile Gly Ser Leu Arg Ala Leu Asn Leu Ser Leu Cys Lys
        115                 120                 125             
Gln Ile Thr Asp Ser Ser Leu Gly Arg Ile Ala Gln Tyr Leu Lys Gly
    130                 135                 140                 
Leu Glu Val Leu Glu Leu Gly Gly Cys Ser Asn Ile Thr Asn Thr Gly
145                 150                 155                 160 
Leu Leu Leu Ile Ala Trp Gly Leu Gln Arg Leu Lys Ser Leu Asn Leu
                165                 170                 175     
Arg Ser Cys Arg His Leu Ser Asp Val Gly Ile Gly His Leu Ala Gly
            180                 185                 190         
Met Thr Arg Ser Ala Ala Glu Gly Cys Leu Gly Leu Glu Gln Leu Thr
        195                 200                 205             
Leu Gln Asp Cys Gln Lys Leu Thr Asp Leu Ser Leu Lys His Ile Ser
    210                 215                 220                 
Arg Gly Leu Thr Gly Leu Arg Leu Leu Asn Leu Ser Phe Cys Gly Gly
225                 230                 235                 240 
Ile Ser Asp Ala Gly Leu Leu His Leu Ser His Met Gly Ser Leu Arg
                245                 250                 255     
Ser Leu Asn Leu Arg Ser Cys Asp Asn Ile Ser Asp Thr Gly Ile Met
            260                 265                 270         
His Leu Ala Met Gly Ser Leu Arg Leu Ser Gly Leu Asp Val Ser Phe
        275                 280                 285             
Cys Asp Lys Val Gly Asp Gln Ser Leu Ala Tyr Ile Ala Gln Gly Leu
    290                 295                 300                 
Asp Gly Leu Lys Ser Leu Ser Leu Cys Ser Cys His Ile Ser Asp Asp
305                 310                 315                 320 
Gly Ile Asn Arg Met Val Arg Gln Met His Gly Leu Arg Thr Leu Asn
                325                 330                 335     
Ile Gly Gln Cys Val Arg Ile Thr Asp Lys Gly Leu Glu Leu Ile Ala
            340                 345                 350         
Glu His Leu Ser Gln Leu Thr Gly Ile Asp Leu Tyr Gly Cys Thr Arg
        355                 360                 365             
Ile Thr Lys Arg Gly Leu Glu Arg Ile Thr Gln Leu Pro Cys Leu Lys
    370                 375                 380                 
Val Leu Asn Leu Gly Leu Trp Gln Met Thr Asp Ser Glu Lys Glu Ala
385                 390                 395                 400 
Arg Gly Asp Phe Ser Pro Leu Phe Thr Val Arg Thr Arg Gly Ser Ser
                405                 410                 415     
Arg Arg
        


<210> 7401
<211> 566
<212> PRT
<213> Homo sapiens

<400> 7401
Met Glu Val Pro Gln Pro Glu Pro Ala Pro Gly Ser Ala Leu Ser Pro
 1               5                  10                  15      
Ala Gly Val Cys Gly Gly Ala Gln Arg Pro Gly His Leu Pro Gly Leu
            20                  25                  30          
Leu Leu Gly Ser His Gly Leu Leu Gly Ser Pro Val Arg Ala Ala Ala
        35                  40                  45              
Ser Ser Pro Val Thr Thr Leu Thr Gln Thr Met His Asp Leu Ala Gly
    50                  55                  60                  
Leu Gly Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala
65                  70                  75                  80  
Ser Glu Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly
                85                  90                  95      
Leu Cys Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln
            100                 105                 110         
Thr Phe Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu
        115                 120                 125             
Gln Phe Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly
    130                 135                 140                 
His Ser Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly
145                 150                 155                 160 
Arg Arg Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu
                165                 170                 175     
Asp Lys Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr
            180                 185                 190         
His Pro Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu
        195                 200                 205             
Ala Phe Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser
    210                 215                 220                 
Pro Asp Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly
225                 230                 235                 240 
Arg Phe Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly
                245                 250                 255     
Phe Val Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro
            260                 265                 270         
Pro Gly Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu
        275                 280                 285             
Lys Glu Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu
    290                 295                 300                 
Phe Arg Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys
305                 310                 315                 320 
Arg Leu Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg
                325                 330                 335     
Arg Arg Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro
            340                 345                 350         
Lys Ala Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu
        355                 360                 365             
Asn Leu Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys
    370                 375                 380                 
Ala Phe Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr
385                 390                 395                 400 
Ile Ser Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn
                405                 410                 415     
Ile Val Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr
            420                 425                 430         
Glu Gly Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp
        435                 440                 445             
Ala Glu Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp
    450                 455                 460                 
Lys Arg Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly
465                 470                 475                 480 
Pro Arg Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp
                485                 490                 495     
Tyr Pro Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr
            500                 505                 510         
Lys Glu Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr
        515                 520                 525             
Arg Pro Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg
    530                 535                 540                 
Leu Lys Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys
545                 550                 555                 560 
Ser Arg Leu Gln Asp Gln
                565     


<210> 7402
<211> 601
<212> PRT
<213> Homo sapiens

<400> 7402
Met Glu Val Pro Gln Pro Glu Pro Ala Pro Gly Ser Ala Leu Ser Pro
 1               5                  10                  15      
Ala Gly Val Cys Gly Gly Ala Gln Arg Pro Gly His Leu Pro Gly Leu
            20                  25                  30          
Leu Leu Gly Ser His Gly Leu Leu Gly Ser Pro Val Arg Ala Ala Ala
        35                  40                  45              
Ser Ser Pro Val Thr Thr Leu Thr Gln Thr Met His Asp Leu Ala Gly
    50                  55                  60                  
Leu Gly Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala
65                  70                  75                  80  
Ser Glu Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly
                85                  90                  95      
Leu Cys Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln
            100                 105                 110         
Thr Phe Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu
        115                 120                 125             
Gln Phe Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly
    130                 135                 140                 
His Ser Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly
145                 150                 155                 160 
Arg Arg Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu
                165                 170                 175     
Asp Lys Glu Asn Val Arg Phe Trp Lys Ala Gly Val Gly Ala Leu Arg
            180                 185                 190         
Glu Glu Glu Gly Ala Cys Trp Gly Gly Ser Leu Ala Cys Glu Asp Pro
        195                 200                 205             
Pro Leu Pro Ser Trp Leu Gln Asp Gly Phe Val Phe Lys Met Pro Trp
    210                 215                 220                 
Lys Pro Thr His Pro Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser
225                 230                 235                 240 
Arg Arg Glu Ala Phe Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met
                245                 250                 255     
Cys Leu Ser Pro Asp Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu
            260                 265                 270         
Ala Leu Gly Arg Phe Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu
        275                 280                 285             
Asp Asp Gly Phe Val Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp
    290                 295                 300                 
Ala Val Pro Pro Gly Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys
305                 310                 315                 320 
Thr Leu Glu Lys Glu Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys
                325                 330                 335     
Gln Arg Leu Phe Arg Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro
            340                 345                 350         
Ile Leu Lys Arg Leu Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln
        355                 360                 365             
Asn Lys Arg Arg Arg Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala
    370                 375                 380                 
Glu Glu Pro Lys Ala Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp
385                 390                 395                 400 
Glu Ile Glu Asn Leu Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp
                405                 410                 415     
Tyr Ser Lys Ala Phe Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp
            420                 425                 430         
Leu Lys Tyr Ile Ser Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys
        435                 440                 445             
Phe Ser Asn Ile Val Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro
    450                 455                 460                 
Tyr Glu Tyr Glu Gly Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu
465                 470                 475                 480 
Glu Arg Asp Ala Glu Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys
                485                 490                 495     
Ser Leu Asp Lys Arg Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser
            500                 505                 510         
Glu Arg Gly Pro Arg Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala
        515                 520                 525             
Val Asn Asp Tyr Pro Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys
    530                 535                 540                 
Gly Gly Tyr Lys Glu Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro
545                 550                 555                 560 
Gln Asp Tyr Arg Pro Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys
                565                 570                 575     
Thr Phe Arg Leu Lys Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg
            580                 585                 590         
Glu Leu Cys Ser Arg Leu Gln Asp Gln
        595                 600     


<210> 7403
<211> 305
<212> PRT
<213> Homo sapiens

<400> 7403
Thr Gln Thr Met His Asp Leu Ala Gly Leu Gly Ser Glu Thr Pro Lys
 1               5                  10                  15      
Ser Gln Val Gly Thr Leu Leu Phe Arg Ser Arg Ser Arg Leu Thr His
            20                  25                  30          
Leu Ser Leu Ser Arg Arg Ala Ser Glu Ser Ser Leu Ser Ser Glu Ser
        35                  40                  45              
Ser Glu Ser Ser Asp Ala Gly Leu Cys Met Asp Ser Pro Ser Pro Met
    50                  55                  60                  
Asp Pro His Met Ala Glu Gln Thr Phe Glu Gln Ala Ile Gln Ala Ala
65                  70                  75                  80  
Ser Arg Ile Ile Arg Asn Glu Gln Phe Ala Ile Arg Arg Phe Gln Ser
                85                  90                  95      
Met Pro Val Arg Leu Leu Gly His Ser Pro Val Leu Arg Asn Ile Thr
            100                 105                 110         
Asn Ser Gln Ala Pro Asp Gly Arg Arg Lys Ser Glu Ala Gly Ser Gly
        115                 120                 125             
Ala Ala Ser Ser Ser Gly Glu Asp Lys Glu Asn Val Arg Phe Trp Lys
    130                 135                 140                 
Ala Gly Val Gly Ala Leu Arg Glu Glu Glu Gly Ala Cys Trp Gly Gly
145                 150                 155                 160 
Ser Leu Ala Cys Glu Asp Pro Pro Leu Pro Ser Trp Leu Gln Asp Gly
                165                 170                 175     
Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro Ser Ser Thr His
            180                 185                 190         
Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe Ala Gln Arg Pro
        195                 200                 205             
Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp Arg Lys Met Glu
    210                 215                 220                 
Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe Ser Leu Thr Pro
225                 230                 235                 240 
Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val Asp Ile Leu Glu
                245                 250                 255     
Ser Asp Leu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe
            260                 265                 270         
Arg Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg
        275                 280                 285             
Leu Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg
    290                 295                 300                 
Arg
305 


<210> 7404
<211> 580
<212> PRT
<213> Homo sapiens

<400> 7404
Met Glu Val Pro Gln Pro Glu Pro Ala Pro Gly Ser Ala Leu Ser Pro
 1               5                  10                  15      
Ala Gly Val Cys Gly Gly Ala Gln Arg Pro Gly His Leu Pro Gly Leu
            20                  25                  30          
Leu Leu Gly Ser His Gly Leu Leu Gly Ser Pro Val Arg Ala Ala Ala
        35                  40                  45              
Ser Ser Pro Val Thr Thr Leu Thr Gln Thr Met His Asp Leu Ala Gly
    50                  55                  60                  
Leu Gly Ser Glu Thr Pro Lys Ser Gln Val Gly Thr Leu Leu Phe Arg
65                  70                  75                  80  
Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala Ser Glu
                85                  90                  95      
Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly Leu Cys
            100                 105                 110         
Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln Thr Phe
        115                 120                 125             
Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu Gln Phe
    130                 135                 140                 
Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly His Ser
145                 150                 155                 160 
Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly Arg Arg
                165                 170                 175     
Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu Asp Lys
            180                 185                 190         
Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro
        195                 200                 205             
Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe
    210                 215                 220                 
Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp
225                 230                 235                 240 
Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe
                245                 250                 255     
Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val
            260                 265                 270         
Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro Pro Gly
        275                 280                 285             
Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu Lys Glu
    290                 295                 300                 
Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe Arg
305                 310                 315                 320 
Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg Leu
                325                 330                 335     
Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg Arg
            340                 345                 350         
Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro Lys Ala
        355                 360                 365             
Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu Asn Leu
    370                 375                 380                 
Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys Ala Phe
385                 390                 395                 400 
Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr Ile Ser
                405                 410                 415     
Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn Ile Val
            420                 425                 430         
Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly
        435                 440                 445             
Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp Ala Glu
    450                 455                 460                 
Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp Lys Arg
465                 470                 475                 480 
Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg
                485                 490                 495     
Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp Tyr Pro
            500                 505                 510         
Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr Lys Glu
        515                 520                 525             
Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr Arg Pro
    530                 535                 540                 
Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg Leu Lys
545                 550                 555                 560 
Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys Ser Arg
                565                 570                 575     
Leu Gln Asp Gln
            580 


<210> 7405
<211> 394
<212> PRT
<213> Homo sapiens

<400> 7405
Val Pro Gly Asn Ile Val Ser Leu Gly His Gly Gly Leu Asn Gln Leu
 1               5                  10                  15      
Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln
            20                  25                  30          
Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser
        35                  40                  45              
Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg
    50                  55                  60                  
Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys
65                  70                  75                  80  
Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys
                85                  90                  95      
Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu
            100                 105                 110         
Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile
        115                 120                 125             
Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met
    130                 135                 140                 
Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile
145                 150                 155                 160 
Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu
                165                 170                 175     
Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly
            180                 185                 190         
Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu
        195                 200                 205             
Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg
    210                 215                 220                 
Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe
225                 230                 235                 240 
Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys
                245                 250                 255     
Gly Glu Gln Val Arg Ser Trp Ala Leu Gly Gly Leu Tyr Pro Leu Pro
            260                 265                 270         
Leu Leu Asn Ser Thr Leu Asp Asp Gly Lys Ala Thr Leu Thr Pro Ser
        275                 280                 285             
Asn Thr Pro Leu Gly Arg Asn Leu Ser Thr His Gln Thr Tyr Pro Val
    290                 295                 300                 
Val Ala Gly Arg Glu Met Val Gly Pro Thr Leu Pro Gly Tyr Pro Pro
305                 310                 315                 320 
His Ile Pro Thr Ser Gly Gln Gly Ser Tyr Ala Ser Ser Ala Ile Ala
                325                 330                 335     
Gly Met Val Ala Gly Ser Glu Tyr Ser Gly Asn Ala Tyr Gly His Thr
            340                 345                 350         
Pro Tyr Ser Ser Tyr Ser Glu Ala Trp Arg Phe Pro Asn Ser Ser Leu
        355                 360                 365             
Leu Ser Ser Pro Tyr Tyr Tyr Ser Ser Thr Ser Arg Pro Ser Ala Pro
    370                 375                 380                 
Pro Thr Thr Ala Thr Ala Phe Asp His Leu
385                 390                 


<210> 7406
<211> 457
<212> PRT
<213> Homo sapiens

<400> 7406
Val Pro Gly Asn Ile Val Ser Leu Gly His Gly Gly Leu Asn Gln Leu
 1               5                  10                  15      
Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln
            20                  25                  30          
Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser
        35                  40                  45              
Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg
    50                  55                  60                  
Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys
65                  70                  75                  80  
Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys
                85                  90                  95      
Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu
            100                 105                 110         
Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile
        115                 120                 125             
Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met
    130                 135                 140                 
Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile
145                 150                 155                 160 
Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu
                165                 170                 175     
Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly
            180                 185                 190         
Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu
        195                 200                 205             
Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg
    210                 215                 220                 
Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe
225                 230                 235                 240 
Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys
                245                 250                 255     
Gly Glu Gln Val Arg Ser Trp Ala Leu Gly Gly Leu Tyr Pro Leu Pro
            260                 265                 270         
Leu Leu Asn Ser Thr Leu Asp Asp Gly Lys Ala Thr Leu Thr Pro Ser
        275                 280                 285             
Asn Thr Pro Leu Gly Arg Asn Leu Ser Thr His Gln Thr Tyr Pro Val
    290                 295                 300                 
Val Ala Asp Pro His Ser Pro Phe Ala Ile Lys Gln Glu Thr Pro Glu
305                 310                 315                 320 
Val Ser Ser Ser Ser Ser Thr Pro Ser Ser Leu Ser Ser Ser Ala Phe
                325                 330                 335     
Leu Asp Leu Gln Gln Val Gly Ser Gly Val Pro Pro Phe Asn Ala Phe
            340                 345                 350         
Pro His Ala Ala Ser Val Tyr Gly Gln Phe Thr Gly Gln Ala Leu Leu
        355                 360                 365             
Ser Gly Arg Glu Met Val Gly Pro Thr Leu Pro Gly Tyr Pro Pro His
    370                 375                 380                 
Ile Pro Thr Ser Gly Gln Gly Ser Tyr Ala Ser Ser Ala Ile Ala Gly
385                 390                 395                 400 
Met Val Ala Gly Ser Glu Tyr Ser Gly Asn Ala Tyr Gly His Thr Pro
                405                 410                 415     
Tyr Ser Ser Tyr Ser Glu Ala Trp Arg Phe Pro Asn Ser Ser Leu Leu
            420                 425                 430         
Ser Ser Pro Tyr Tyr Tyr Ser Ser Thr Ser Arg Pro Ser Ala Pro Pro
        435                 440                 445             
Thr Thr Ala Thr Ala Phe Asp His Leu
    450                 455         


<210> 7407
<211> 321
<212> PRT
<213> Homo sapiens

<400> 7407
Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu
 1               5                  10                  15      
Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln
            20                  25                  30          
Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser
        35                  40                  45              
Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg
    50                  55                  60                  
Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys
65                  70                  75                  80  
Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys
                85                  90                  95      
Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu
            100                 105                 110         
Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile
        115                 120                 125             
Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met
    130                 135                 140                 
Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile
145                 150                 155                 160 
Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu
                165                 170                 175     
Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly
            180                 185                 190         
Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu
        195                 200                 205             
Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg
    210                 215                 220                 
Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe
225                 230                 235                 240 
Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys
                245                 250                 255     
Gly Glu Gln Gly Glu Arg Trp Trp Gly Pro Arg Cys Pro Asp Thr His
            260                 265                 270         
Pro Thr Ser Pro Pro Ala Asp Arg Ala Ala Met Pro Pro Leu Pro Ser
        275                 280                 285             
Gln Ala Trp Trp Gln Glu Val Asn Thr Leu Ala Met Pro Met Ala Thr
    290                 295                 300                 
Pro Pro Thr Pro Pro Thr Ala Arg Pro Gly Ala Ser Pro Thr Pro Ala
305                 310                 315                 320 
Cys
    


<210> 7408
<211> 399
<212> PRT
<213> Homo sapiens

<400> 7408
Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu
 1               5                  10                  15      
Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln
            20                  25                  30          
Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser
        35                  40                  45              
Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg
    50                  55                  60                  
Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys
65                  70                  75                  80  
Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys
                85                  90                  95      
Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu
            100                 105                 110         
Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile
        115                 120                 125             
Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met
    130                 135                 140                 
Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile
145                 150                 155                 160 
Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu
                165                 170                 175     
Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly
            180                 185                 190         
Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu
        195                 200                 205             
Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg
    210                 215                 220                 
Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe
225                 230                 235                 240 
Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys
                245                 250                 255     
Gly Glu Gln Gly Leu Tyr Pro Leu Pro Leu Leu Asn Ser Thr Leu Asp
            260                 265                 270         
Asp Gly Lys Ala Thr Leu Thr Pro Ser Asn Thr Pro Leu Gly Arg Asn
        275                 280                 285             
Leu Ser Thr His Gln Thr Tyr Pro Val Val Ala Asp Ala Pro Pro Phe
    290                 295                 300                 
Trp Ile Cys Ser Lys Ser Ala Pro Gly Ser Arg Pro Ser Met Pro Phe
305                 310                 315                 320 
Pro Met Leu Pro Pro Cys Thr Gly Ser Ser Arg Ala Arg Pro Ser Ser
                325                 330                 335     
Gln Gly Glu Arg Trp Trp Gly Pro Arg Cys Pro Asp Thr His Pro Thr
            340                 345                 350         
Ser Pro Pro Ala Asp Arg Ala Ala Met Pro Pro Leu Pro Ser Gln Ala
        355                 360                 365             
Trp Trp Gln Glu Val Asn Thr Leu Ala Met Pro Met Ala Thr Pro Pro
    370                 375                 380                 
Thr Pro Pro Thr Ala Arg Pro Gly Ala Ser Pro Thr Pro Ala Cys
385                 390                 395                 


<210> 7409
<211> 287
<212> PRT
<213> Homo sapiens

<400> 7409
Met Pro His Asn Ser Ile Arg Ser Gly His Gly Gly Leu Asn Gln Leu
 1               5                  10                  15      
Gly Gly Ala Phe Val Asn Gly Arg Pro Leu Pro Glu Val Val Arg Gln
            20                  25                  30          
Arg Ile Val Asp Leu Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser
        35                  40                  45              
Arg Gln Leu Arg Val Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg
    50                  55                  60                  
Tyr Tyr Glu Thr Gly Ser Ile Arg Pro Gly Val Ile Gly Gly Ser Lys
65                  70                  75                  80  
Pro Lys Val Ala Thr Pro Lys Val Val Glu Lys Ile Gly Asp Tyr Lys
                85                  90                  95      
Arg Gln Asn Pro Thr Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu
            100                 105                 110         
Ala Glu Gly Val Cys Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile
        115                 120                 125             
Asn Arg Ile Ile Arg Thr Lys Val Gln Gln Pro Phe Asn Leu Pro Met
    130                 135                 140                 
Asp Ser Cys Val Ala Thr Lys Ser Leu Ser Pro Gly His Thr Leu Ile
145                 150                 155                 160 
Pro Ser Ser Ala Val Thr Pro Pro Glu Ser Pro Gln Ser Asp Ser Leu
                165                 170                 175     
Gly Ser Thr Tyr Ser Ile Asn Gly Leu Leu Gly Ile Ala Gln Pro Gly
            180                 185                 190         
Ser Asp Lys Arg Lys Met Asp Asp Ser Asp Gln Asp Ser Cys Arg Leu
        195                 200                 205             
Ser Ile Asp Ser Gln Ser Ser Ser Ser Gly Pro Arg Lys His Leu Arg
    210                 215                 220                 
Thr Asp Ala Phe Ser Gln His His Leu Glu Pro Leu Glu Cys Pro Phe
225                 230                 235                 240 
Glu Arg Gln His Tyr Pro Glu Ala Tyr Ala Ser Pro Ser His Thr Lys
                245                 250                 255     
Gly Glu Gln Glu Val Asn Thr Leu Ala Met Pro Met Ala Thr Pro Pro
            260                 265                 270         
Thr Pro Pro Thr Ala Arg Pro Gly Ala Ser Pro Thr Pro Ala Cys
        275                 280                 285         


<210> 7410
<211> 144
<212> PRT
<213> Homo sapiens

<400> 7410
Met Gly Leu Thr Ile Lys Gly Leu Ile Ser Leu Gly Pro Ser Ala Ser
 1               5                  10                  15      
Trp Leu Gly Glu Leu Asn Arg Leu Lys Tyr Gln Ala Gln Asn Ile Thr
            20                  25                  30          
Ser Gly Asp Thr Thr Thr Ile Leu Pro Ala Ala Cys Cys Thr Met Lys
        35                  40                  45              
Ser Ala Lys Leu Gly Phe Leu Leu Arg Phe Phe Ile Phe Cys Ser Leu
    50                  55                  60                  
Asn Thr Leu Leu Leu Gly Gly Val Asn Lys Ile Ala Glu Lys Ile Cys
65                  70                  75                  80  
Gly Asp Leu Lys Asp Pro Cys Lys Leu Asp Met Asn Phe Gly Ser Cys
                85                  90                  95      
Tyr Glu Val His Phe Arg Tyr Phe Tyr Asn Arg Thr Ser Lys Arg Cys
            100                 105                 110         
Glu Thr Phe Val Phe Ser Gly Cys Asn Gly Asn Leu Asn Asn Phe Lys
        115                 120                 125             
Leu Lys Ile Glu Arg Glu Val Ala Cys Val Ala Lys Tyr Lys Pro Pro
    130                 135                 140                 


<210> 7411
<211> 1971
<212> PRT
<213> Homo sapiens

<400> 7411
Lys Leu Arg Glu Asn Lys Lys Thr Ala Glu Leu Ile Lys Thr Ala Asn
 1               5                  10                  15      
Leu Leu Phe Asn Ser Phe Glu Pro Tyr Tyr Met Trp Asp Tyr Val Ala
            20                  25                  30          
Arg Trp Phe Glu Glu Cys Cys Arg Arg Thr Leu His Val Arg Leu Gln
        35                  40                  45              
Ile Gly Pro Gly Asp Ser Asn Asp Ser Ser Glu Leu Gln Leu Thr Asn
    50                  55                  60                  
Phe Cys Leu Leu Val Asp Phe Leu Leu Asp Ile Val Ser Leu Glu Thr
65                  70                  75                  80  
Tyr Ile Glu Ile Gln Thr Glu His Leu Pro Gln Leu Leu Leu Arg Met
                85                  90                  95      
Ile Ser Ala Leu Thr Ser His Leu Gln Thr Leu His Leu Ser Glu Leu
            100                 105                 110         
Thr Asp Ser Leu Arg Leu Cys Ser Lys Ile Leu Ser Lys Val Gln Pro
        115                 120                 125             
Pro Leu Leu Ser Ala Ser Thr Gly Gly Val Leu Gln Phe Pro Ser Gly
    130                 135                 140                 
Gln Asn Asn Ser Val Lys Glu Trp Glu Asp Lys Lys Val Ser Ser Val
145                 150                 155                 160 
Ser His Glu Asn Pro Thr Glu Val Phe Glu Asp Gly Glu Asn Pro Pro
                165                 170                 175     
Ser Ser Arg Ser Ser Glu Ser Gly Phe Thr Glu Phe Ile Gln Tyr Gln
            180                 185                 190         
Ala Asp Arg Thr Asp Asp Ile Asp Arg Glu Leu Ser Glu Gly Gln Gly
        195                 200                 205             
Ala Ala Ala Ile Pro Ile Gly Ser Thr Ser Ser Glu Thr Glu Thr Ala
    210                 215                 220                 
Ser Thr Val Gly Ser Glu Glu Thr Ile Ile Gln Thr Pro Ser Val Val
225                 230                 235                 240 
Thr Gln Gly Thr Ala Thr Arg Ser Arg Lys Thr Ala Gln Lys Thr Ala
                245                 250                 255     
Met Gln Cys Cys Leu Glu Tyr Val Gln Gln Phe Leu Thr Arg Leu Ile
            260                 265                 270         
Asn Leu Tyr Ile Ile Gln Asn Asn Ser Phe Ser Gln Ser Leu Ala Thr
        275                 280                 285             
Glu His Gln Gly Asp Leu Gly Arg Glu Gln Gly Glu Thr Ser Lys Trp
    290                 295                 300                 
Asp Arg Asn Ser Gln Gly Asp Val Lys Glu Lys Asn Ile Ser Lys Gln
305                 310                 315                 320 
Lys Thr Ser Lys Glu Tyr Leu Ser Ala Phe Leu Ala Ala Cys Gln Leu
                325                 330                 335     
Phe Leu Glu Cys Ser Ser Phe Pro Val Tyr Ile Ala Glu Gly Asn His
            340                 345                 350         
Thr Ser Glu Leu Arg Ser Glu Lys Leu Glu Thr Asp Cys Glu His Val
        355                 360                 365             
Gln Pro Pro Gln Trp Leu Gln Thr Leu Met Asn Ala Cys Ser Gln Ala
    370                 375                 380                 
Ser Asp Phe Ser Val Gln Ser Val Ala Ile Ser Leu Val Met Asp Leu
385                 390                 395                 400 
Val Gly Leu Thr Gln Ser Val Ala Met Val Thr Gly Glu Asn Ile Asn
                405                 410                 415     
Ser Val Glu Pro Ala Gln Pro Leu Ser Pro Asn Gln Gly Arg Val Ala
            420                 425                 430         
Val Val Ile Arg Pro Pro Leu Thr Gln Gly Asn Leu Arg Tyr Ile Ala
        435                 440                 445             
Glu Lys Thr Glu Phe Phe Lys His Val Ala Leu Thr Leu Trp Asp Gln
    450                 455                 460                 
Leu Gly Asp Gly Thr Pro Gln His His Gln Lys Ser Val Glu Leu Phe
465                 470                 475                 480 
Tyr Gln Leu His Asn Leu Val Pro Ser Ser Ser Ile Cys Glu Asp Val
                485                 490                 495     
Ile Ser Gln Gln Leu Thr His Lys Asp Lys Lys Ile Arg Met Glu Ala
            500                 505                 510         
His Ala Lys Phe Ala Val Leu Trp His Leu Thr Arg Asp Leu His Ile
        515                 520                 525             
Asn Lys Ser Ser Ser Phe Val Arg Ser Phe Asp Arg Ser Leu Phe Ile
    530                 535                 540                 
Met Leu Asp Ser Leu Asn Ser Leu Asp Gly Ser Thr Ser Ser Val Gly
545                 550                 555                 560 
Gln Ala Trp Leu Asn Gln Val Leu Gln Arg His Asp Ile Ala Arg Val
                565                 570                 575     
Leu Glu Pro Leu Leu Leu Leu Leu Leu His Pro Lys Thr Gln Arg Val
            580                 585                 590         
Ser Val Gln Arg Val Gln Ala Glu Arg Tyr Trp Asn Lys Ser Pro Cys
        595                 600                 605             
Tyr Pro Gly Glu Glu Ser Asp Lys His Phe Met Gln Asn Phe Ala Cys
    610                 615                 620                 
Ser Asn Val Ser Gln Val Gln Leu Ile Thr Ser Lys Gly Asn Gly Glu
625                 630                 635                 640 
Lys Pro Leu Thr Met Asp Glu Ile Glu Asn Phe Ser Leu Thr Val Asn
                645                 650                 655     
Pro Leu Ser Asp Arg Leu Ser Leu Leu Ser Thr Ser Ser Glu Thr Ile
            660                 665                 670         
Pro Met Val Val Ser Asp Phe Asp Leu Pro Asp Gln Gln Ile Glu Ile
        675                 680                 685             
Leu Gln Ser Ser Asp Ser Gly Cys Ser Gln Ser Ser Ala Gly Asp Asn
    690                 695                 700                 
Leu Ser Tyr Glu Val Asp Pro Glu Thr Val Asn Ala Gln Glu Asp Ser
705                 710                 715                 720 
Gln Met Pro Lys Glu Ser Ser Pro Asp Asp Asp Val Gln Gln Val Val
                725                 730                 735     
Phe Asp Leu Ile Cys Lys Val Val Ser Gly Leu Glu Val Glu Ser Ala
            740                 745                 750         
Ser Val Thr Ser Gln Leu Glu Ile Glu Ala Met Pro Pro Lys Cys Ser
        755                 760                 765             
Asp Ile Asp Pro Asp Glu Glu Thr Ile Lys Ile Glu Asp Asp Ser Ile
    770                 775                 780                 
Gln Gln Ser Gln Asn Ala Leu Leu Ser Asn Glu Ser Ser Gln Phe Leu
785                 790                 795                 800 
Ser Val Ser Ala Glu Gly Gly His Glu Cys Val Ala Asn Gly Ile Ser
                805                 810                 815     
Arg Asn Ser Ser Ser Pro Cys Ile Ser Gly Thr Thr His Thr Leu His
            820                 825                 830         
Asp Ser Ser Val Ala Ser Ile Glu Thr Lys Ser Arg Gln Arg Ser His
        835                 840                 845             
Ser Ser Ile Gln Phe Ser Phe Lys Glu Lys Leu Ser Glu Lys Val Ser
    850                 855                 860                 
Glu Lys Glu Thr Ile Val Lys Glu Ser Gly Lys Gln Pro Gly Ala Lys
865                 870                 875                 880 
Pro Lys Val Lys Leu Ala Arg Lys Lys Asp Asp Asp Lys Lys Lys Ser
                885                 890                 895     
Ser Asn Glu Lys Leu Lys Gln Thr Ser Val Phe Phe Ser Asp Gly Leu
            900                 905                 910         
Asp Leu Glu Asn Trp Tyr Ser Cys Gly Glu Gly Asp Ile Ser Glu Ile
        915                 920                 925             
Glu Ser Asp Met Gly Ser Pro Gly Ser Arg Lys Ser Pro Asn Phe Asn
    930                 935                 940                 
Ile His Pro Leu Tyr Gln His Val Leu Leu Tyr Leu Gln Leu Tyr Asp
945                 950                 955                 960 
Ser Ser Arg Thr Leu Tyr Ala Phe Ser Ala Ile Lys Ala Ile Leu Lys
                965                 970                 975     
Thr Asn Pro Ile Ala Phe Val Asn Ala Ile Ser Thr Thr Ser Val Asn
            980                 985                 990         
Asn Ala Tyr Thr Pro Gln Leu Ser Leu Leu Gln Asn Leu Leu Ala Arg
        995                 1000                1005            
His Arg Ile Ser Val Met Gly Lys Asp Phe Tyr Ser His Ile Pro Val
    1010                1015                1020                
Asp Ser Asn His Asn Phe Arg Ser Ser Met Tyr Ile Glu Ile Leu Ile
1025                1030                1035                1040
Ser Leu Cys Leu Tyr Tyr Met Arg Ser His Tyr Pro Thr His Val Lys
                1045                1050                1055    
Val Thr Ala Gln Asp Leu Ile Gly Asn Arg Asn Met Gln Met Met Ser
            1060                1065                1070        
Ile Glu Ile Leu Thr Leu Leu Phe Thr Glu Leu Ala Lys Val Ile Glu
        1075                1080                1085            
Ser Ser Ala Lys Gly Phe Pro Ser Phe Ile Ser Asp Met Leu Ser Lys
    1090                1095                1100                
Cys Lys Val Gln Lys Val Ile Leu His Cys Leu Leu Ser Ser Ile Phe
1105                1110                1115                1120
Ser Ala Gln Lys Trp His Ser Glu Lys Met Ala Gly Lys Asn Leu Val
                1125                1130                1135    
Ala Val Glu Glu Gly Phe Ser Glu Asp Ser Leu Ile Asn Phe Ser Glu
            1140                1145                1150        
Asp Glu Phe Asp Asn Gly Ser Thr Leu Gln Ser Gln Leu Leu Lys Val
        1155                1160                1165            
Leu Gln Arg Leu Ile Val Leu Glu His Arg Val Met Thr Ile Pro Glu
    1170                1175                1180                
Glu Asn Glu Thr Gly Phe Asp Phe Val Val Ser Asp Leu Glu His Ile
1185                1190                1195                1200
Ser Pro His Gln Pro Met Thr Ser Leu Gln Tyr Leu His Ala Gln Pro
                1205                1210                1215    
Ile Thr Cys Gln Gly Met Phe Leu Cys Ala Val Ile Arg Ala Leu His
            1220                1225                1230        
Gln His Cys Ala Cys Lys Met His Pro Gln Trp Ile Gly Leu Ile Thr
        1235                1240                1245            
Ser Thr Leu Pro Tyr Met Gly Lys Val Leu Gln Arg Val Val Val Ser
    1250                1255                1260                
Val Thr Leu Gln Leu Cys Arg Asn Leu Asp Asn Leu Ile Gln Gln Tyr
1265                1270                1275                1280
Lys Tyr Glu Thr Gly Leu Ser Asp Ser Arg Pro Leu Trp Met Ala Ser
                1285                1290                1295    
Ile Ile Pro Pro Asp Met Ile Leu Thr Leu Leu Glu Gly Ile Thr Ala
            1300                1305                1310        
Ile Ile His Tyr Cys Leu Leu Asp Pro Thr Thr Gln Tyr His Gln Leu
        1315                1320                1325            
Leu Val Ser Val Asp Gln Lys His Leu Phe Glu Ala Arg Ser Gly Ile
    1330                1335                1340                
Leu Ser Ile Leu His Met Ile Met Ser Ser Val Thr Leu Leu Trp Ser
1345                1350                1355                1360
Ile Leu His Gln Ala Asp Ser Ser Glu Lys Met Thr Ile Ala Ala Ser
                1365                1370                1375    
Ala Ser Leu Thr Thr Ile Asn Leu Gly Ala Thr Lys Asn Leu Arg Gln
            1380                1385                1390        
Gln Ile Leu Glu Leu Leu Gly Pro Ile Ser Met Asn His Gly Val His
        1395                1400                1405            
Phe Met Ala Ala Ile Ala Phe Val Trp Asn Glu Arg Arg Gln Asn Lys
    1410                1415                1420                
Thr Thr Thr Arg Thr Lys Val Ile Pro Ala Ala Ser Glu Glu Gln Leu
1425                1430                1435                1440
Leu Leu Val Glu Leu Val Arg Ser Ile Ser Val Met Arg Ala Glu Thr
                1445                1450                1455    
Val Ile Gln Thr Val Lys Glu Val Leu Lys Gln Pro Pro Ala Ile Ala
            1460                1465                1470        
Lys Asp Lys Lys His Leu Ser Leu Glu Val Cys Met Leu Gln Phe Phe
        1475                1480                1485            
Tyr Ala Tyr Ile Gln Arg Val Leu Asn Glu Phe Ile Met Lys Asn Pro
    1490                1495                1500                
Ser Leu Glu Asn Lys Lys Asp Gln Arg Asp Leu Gln Asp Val Thr His
1505                1510                1515                1520
Lys Ile Val Asp Ala Ile Gly Ala Ile Ala Gly Ser Ser Leu Glu Gln
                1525                1530                1535    
Thr Thr Trp Leu Arg Arg Asn Leu Glu Val Lys Pro Ser Pro Lys Ile
            1540                1545                1550        
Met Val Asp Gly Thr Asn Leu Glu Ser Asp Val Glu Gly Ile Leu Val
        1555                1560                1565            
Lys His Leu Gly Leu Leu Ser Val Leu Ala His Leu Leu Asp Met Val
    1570                1575                1580                
Phe Tyr Ser Asp Glu Lys Glu Arg Val Ile Pro Leu Leu Val Asn Ile
1585                1590                1595                1600
Met His Tyr Val Val Pro Tyr Leu Arg Asn His Ser Ala His Asn Ala
                1605                1610                1615    
Pro Ser Tyr Arg Ala Cys Val Gln Leu Leu Ser Ser Leu Ser Gly Tyr
            1620                1625                1630        
Gln Tyr Thr Arg Arg Ala Trp Lys Lys Glu Ala Phe Asp Leu Phe Met
        1635                1640                1645            
Asp Pro Ser Phe Phe Gln Met Asp Ala Ser Cys Val Asn His Trp Arg
    1650                1655                1660                
Ala Ile Met Asp Asn Leu Met Thr His Asp Lys Thr Thr Phe Arg Asp
1665                1670                1675                1680
Leu Met Thr Arg Val Ala Val Ala Gln Ser Ser Ser Leu Asn Leu Phe
                1685                1690                1695    
Ala Asn Arg Asp Val Glu Leu Glu Gln Arg Ala Met Leu Leu Lys Arg
            1700                1705                1710        
Leu Ala Phe Ala Ile Phe Ser Ser Glu Ile Asp Gln Tyr Gln Lys Tyr
        1715                1720                1725            
Leu Pro Asp Ile Gln Gly Ile Pro Val Ser Lys Trp Val Gln Leu Leu
    1730                1735                1740                
Thr Ala Leu Ser Pro Ala Tyr Arg Thr Ser Gly Pro Ser Val Ala Gly
1745                1750                1755                1760
Leu Glu Thr Thr Tyr Thr Gly Gly Asn Gly Phe Ser Thr Ser Tyr Asn
                1765                1770                1775    
Ser Gln Arg Trp Leu Asn Leu Tyr Leu Ser Ala Cys Lys Phe Leu Asp
            1780                1785                1790        
Leu Ala Leu Ala Leu Pro Ser Glu Asn Leu Pro Gln Phe Gln Met Tyr
        1795                1800                1805            
Arg Trp Ala Phe Ile Pro Glu Ala Ser Asp Asp Ser Gly Leu Glu Val
    1810                1815                1820                
Arg Arg Gln Gly Ile His Gln Arg Glu Phe Lys Pro Tyr Val Val Arg
1825                1830                1835                1840
Leu Ala Lys Leu Leu Arg Lys Arg Ala Lys Asp Lys Glu Glu Asp Phe
                1845                1850                1855    
Lys Thr Val Ile Leu Glu Gly Leu Glu Met Ala Lys His Gln Lys Asn
            1860                1865                1870        
Pro Glu Glu Asp Asn Ser Gly Arg Thr Leu Gly Trp Glu Pro Gly His
        1875                1880                1885            
Leu Leu Leu Thr Ile Cys Thr Val Arg Ser Met Glu Gln Leu Leu Pro
    1890                1895                1900                
Phe Phe Asn Val Leu Ser Gln Val Phe Asn Ser Lys Val Thr Ser Arg
1905                1910                1915                1920
Cys Gly Gly His Ser Gly Ser Pro Ile Leu Tyr Ser Asn Ala Phe Pro
                1925                1930                1935    
Asn Lys Asp Met Lys Leu Glu Asn His Lys Pro Cys Ser Ser Lys Ala
            1940                1945                1950        
Arg Gln Lys Ile Glu Glu Met Val Glu Lys Asp Phe Leu Glu Gly Met
        1955                1960                1965            
Ile Lys Thr
    1970    


<210> 7412
<211> 179
<212> PRT
<213> Homo sapiens

<400> 7412
Met Thr Ile Met Thr Asp Gln Thr Met Ala Thr Gly Ile Leu Thr Pro
 1               5                  10                  15      
Val Met Thr Gly Ser Glu Asn Pro Pro Gly Lys Asn Gly Asn Cys Leu
            20                  25                  30          
Glu Ala Arg Ala Glu Gly Arg Pro Gly Ala Glu Pro Val Arg Asp Leu
        35                  40                  45              
Ala Val Ser Arg Glu Gly Arg Leu Gly Thr Phe Thr Thr Gln Asn Ala
    50                  55                  60                  
Ser Ala Pro Arg Asn Pro Glu Thr Pro Gly Ser Pro Val Pro Pro Ser
65                  70                  75                  80  
Gly Arg Pro Cys Pro Ser Ser Pro Arg Gly Ser Phe Ala Val Arg Gly
                85                  90                  95      
Lys Gly Arg Val Ala Ser Ser Gly Pro Phe Ser Ala Ala Thr Ala Ala
            100                 105                 110         
His Pro Ser Thr Ser Ser Arg Ser Pro Ala Thr Ser Cys His Pro Asp
        115                 120                 125             
Phe Pro His Ser Ala Ala Ser Pro Arg Pro Leu Arg Ala Gly Thr Ala
    130                 135                 140                 
Val Pro Ala Asp Ser Ala Lys Gly Lys Ser Leu Leu Pro Ser His Ala
145                 150                 155                 160 
Asn Cys Arg Ala Leu Thr Ala Ala Gly Arg Gly Lys Glu Arg Arg Asn
                165                 170                 175     
Thr Ser Leu
            


<210> 7413
<211> 906
<212> PRT
<213> Homo sapiens

<400> 7413
Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Thr Gly
 1               5                  10                  15      
Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala
            20                  25                  30          
Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro
        35                  40                  45              
Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp
    50                  55                  60                  
Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser
65                  70                  75                  80  
Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg
                85                  90                  95      
Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn
            100                 105                 110         
Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln
        115                 120                 125             
Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn
    130                 135                 140                 
Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His
145                 150                 155                 160 
Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly
                165                 170                 175     
Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys
            180                 185                 190         
Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala
        195                 200                 205             
Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu
    210                 215                 220                 
Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu
225                 230                 235                 240 
Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg
                245                 250                 255     
Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu
            260                 265                 270         
Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro
        275                 280                 285             
Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala
    290                 295                 300                 
Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His
305                 310                 315                 320 
Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe
                325                 330                 335     
Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu
            340                 345                 350         
Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr
        355                 360                 365             
Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys
    370                 375                 380                 
Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met
385                 390                 395                 400 
Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys
                405                 410                 415     
Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp
            420                 425                 430         
Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu
        435                 440                 445             
Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp
    450                 455                 460                 
Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg
465                 470                 475                 480 
Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val
                485                 490                 495     
Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser
            500                 505                 510         
Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His
        515                 520                 525             
Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro
    530                 535                 540                 
Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro
545                 550                 555                 560 
Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp
                565                 570                 575     
Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro
            580                 585                 590         
Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro
        595                 600                 605             
Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu
    610                 615                 620                 
Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr
625                 630                 635                 640 
Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly
                645                 650                 655     
Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala
            660                 665                 670         
Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro
        675                 680                 685             
Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser
    690                 695                 700                 
Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys
705                 710                 715                 720 
Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn
                725                 730                 735     
Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu
            740                 745                 750         
Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu
        755                 760                 765             
Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val
    770                 775                 780                 
Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe
785                 790                 795                 800 
Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly
                805                 810                 815     
Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn
            820                 825                 830         
Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala
        835                 840                 845             
Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu
    850                 855                 860                 
Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile
865                 870                 875                 880 
Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val
                885                 890                 895     
Ser Ile Ser Ser Pro Ala His Val Ala Thr
            900                 905     


<210> 7414
<211> 478
<212> PRT
<213> Homo sapiens

<400> 7414
Met Val Gln Lys Thr Ser Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln
 1               5                  10                  15      
Glu Ile Pro Met Glu Val Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser
            20                  25                  30          
Lys Arg Lys Gly Arg Phe Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp
        35                  40                  45              
Thr Thr Ser Asn Ser Phe Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr
    50                  55                  60                  
Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu Ala
65                  70                  75                  80  
Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala
                85                  90                  95      
Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr Asn
            100                 105                 110         
Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr Phe
        115                 120                 125             
Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp Trp
    130                 135                 140                 
Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile Pro
145                 150                 155                 160 
Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Lys Leu
                165                 170                 175     
Arg Gln Asn Arg Leu Gly Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser
            180                 185                 190         
Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala
        195                 200                 205             
Ser Ala Lys Gln Lys Gln Lys Ser Thr Glu His Val Pro Pro Tyr Asp
    210                 215                 220                 
Val Val Pro Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu Lys
225                 230                 235                 240 
Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu
                245                 250                 255     
Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp
            260                 265                 270         
Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ile
        275                 280                 285             
Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser
    290                 295                 300                 
Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Ala
305                 310                 315                 320 
Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser
                325                 330                 335     
Leu Ala Pro Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu
            340                 345                 350         
Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu Asn
        355                 360                 365             
Val Gln Ile Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu Met
    370                 375                 380                 
Phe Asp Ile Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His
385                 390                 395                 400 
Leu Ala Glu Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser
                405                 410                 415     
Ser Thr Pro Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala Ala
            420                 425                 430         
Leu Ala Ala Ser Pro Ala Pro Val Ser Asn Leu Gln Val Gln Val Leu
        435                 440                 445             
Thr Ser Leu Arg Arg Asn Leu Gly Phe Trp Gly Gly Leu Glu Ser Ser
    450                 455                 460                 
Gln Arg Gly Ser Val Val Pro Gln Glu Gln Glu His Ala Met
465                 470                 475             


<210> 7415
<211> 523
<212> PRT
<213> Homo sapiens

<400> 7415
Met Val Gln Lys Thr Ser Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln
 1               5                  10                  15      
Glu Ile Pro Met Glu Val Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser
            20                  25                  30          
Lys Arg Lys Gly Arg Phe Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp
        35                  40                  45              
Thr Thr Ser Asn Ser Phe Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr
    50                  55                  60                  
Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu Ala
65                  70                  75                  80  
Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala
                85                  90                  95      
Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr Asn
            100                 105                 110         
Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr Phe
        115                 120                 125             
Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp Trp
    130                 135                 140                 
Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile Pro
145                 150                 155                 160 
Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Lys Leu
                165                 170                 175     
Arg Gln Asn Arg Leu Gly Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser
            180                 185                 190         
Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala
        195                 200                 205             
Ser Gly Asn Glu Met Thr Asn Leu Ala Phe Glu Leu Asp Pro Leu Glu
    210                 215                 220                 
Leu Glu Glu Glu Glu Ala Glu Leu Gly Glu Gln Ser Gly Ser Ala Lys
225                 230                 235                 240 
Thr Ser Val Ser Ser Val Thr Thr Pro Pro Pro His Gly Lys Arg Ile
                245                 250                 255     
Pro Phe Phe Lys Lys Thr Glu His Val Pro Pro Tyr Asp Val Val Pro
            260                 265                 270         
Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu
        275                 280                 285             
Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg
    290                 295                 300                 
Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu
305                 310                 315                 320 
Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ile Ile Ile Glu
                325                 330                 335     
Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu
            340                 345                 350         
Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Ala Leu Asp Ala
        355                 360                 365             
Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro
    370                 375                 380                 
Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu Gln Arg Leu
385                 390                 395                 400 
Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu Asn Val Gln Ile
                405                 410                 415     
Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu Met Phe Asp Ile
            420                 425                 430         
Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu
        435                 440                 445             
Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Thr Pro
    450                 455                 460                 
Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala Ala Leu Ala Ala
465                 470                 475                 480 
Ser Pro Ala Pro Val Ser Asn Leu Gln Val Gln Val Leu Thr Ser Leu
                485                 490                 495     
Arg Arg Asn Leu Gly Phe Trp Gly Gly Leu Glu Ser Ser Gln Arg Gly
            500                 505                 510         
Ser Val Val Pro Gln Glu Gln Glu His Ala Met
        515                 520             


<210> 7416
<211> 599
<212> PRT
<213> Homo sapiens

<400> 7416
Met Val Gln Lys Thr Ser Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln
 1               5                  10                  15      
Glu Ile Pro Met Glu Val Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser
            20                  25                  30          
Lys Arg Lys Gly Arg Phe Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp
        35                  40                  45              
Thr Thr Ser Asn Ser Phe Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr
    50                  55                  60                  
Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu Ala
65                  70                  75                  80  
Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala
                85                  90                  95      
Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr Asn
            100                 105                 110         
Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr Phe
        115                 120                 125             
Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp Trp
    130                 135                 140                 
Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile Pro
145                 150                 155                 160 
Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Lys Leu
                165                 170                 175     
Arg Gln Asn Arg Leu Gly Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser
            180                 185                 190         
Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala
        195                 200                 205             
Ser Gly Lys Ser His Arg His Ala Gly Thr Glu His Val Pro Pro Tyr
    210                 215                 220                 
Asp Val Val Pro Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu
225                 230                 235                 240 
Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe
                245                 250                 255     
Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala
            260                 265                 270         
Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His
        275                 280                 285             
Ile Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln
    290                 295                 300                 
Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val
305                 310                 315                 320 
Ala Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr
                325                 330                 335     
Ser Leu Ala Pro Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val
            340                 345                 350         
Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu
        355                 360                 365             
Asn Val Gln Ile Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu
    370                 375                 380                 
Met Phe Asp Ile Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu
385                 390                 395                 400 
His Leu Ala Glu Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro
                405                 410                 415     
Ser Ser Thr Pro Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala
            420                 425                 430         
Ala Leu Ala Ala Ser Pro Ala Pro Val Ser Asn Leu Gln Gly Pro Tyr
        435                 440                 445             
Leu Ala Ser Gly Asp Gln Pro Leu Glu Arg Ala Thr Gly Glu His Ala
    450                 455                 460                 
Ser Met His Glu Tyr Pro Gly Glu Leu Gly Gln Pro Pro Gly Leu Tyr
465                 470                 475                 480 
Pro Ser Ser His Pro Pro Gly Arg Ala Gly Thr Leu Arg Ala Leu Ser
                485                 490                 495     
Arg Gln Asp Thr Phe Asp Ala Asp Thr Pro Gly Ser Arg Asn Ser Ala
            500                 505                 510         
Tyr Thr Glu Leu Gly Asp Ser Cys Val Asp Met Glu Thr Asp Pro Ser
        515                 520                 525             
Glu Gly Pro Gly Leu Gly Asp Pro Ala Gly Gly Gly Thr Pro Pro Ala
    530                 535                 540                 
Arg Gln Gly Ser Trp Glu Asp Glu Glu Glu Asp Tyr Glu Glu Glu Leu
545                 550                 555                 560 
Thr Asp Asn Arg Asn Arg Gly Arg Asn Lys Ala Arg Tyr Cys Ala Glu
                565                 570                 575     
Gly Gly Gly Pro Val Leu Gly Arg Asn Lys Asn Glu Leu Glu Gly Trp
            580                 585                 590         
Gly Arg Gly Val Tyr Ile Arg
        595                 


<210> 7417
<211> 114
<212> PRT
<213> Homo sapiens

<400> 7417
Phe Leu Ala Ser Arg Leu Gly Pro Val Ser Thr Ala Asn Met Ser Arg
 1               5                  10                  15      
Pro Val Arg Asn Arg Lys Val Val Asp Tyr Ser Gln Phe Gln Glu Ser
            20                  25                  30          
Asp Asp Ala Asp Glu Asp Ser Glu Asp Ser Glu Asp Lys Asp Val Lys
        35                  40                  45              
Thr Lys Lys Asp Asp Ser His Ser Ala Glu Asp Ser Glu Asp Glu Lys
    50                  55                  60                  
Glu Asp His Lys Asn Val Arg Gln Gln Arg Gln Ala Ala Ser Lys Ala
65                  70                  75                  80  
Ala Ser Lys Gln Arg Glu Met Leu Met Glu Asp Val Gly Ser Glu Glu
                85                  90                  95      
Glu Gln Glu Glu Glu Asp Glu Ala Pro Phe Gln Glu Lys Asp Ser Gly
            100                 105                 110         
Ser Arg
        


<210> 7418
<211> 289
<212> PRT
<213> Homo sapiens

<400> 7418
Asp Gly Gly Ala Gly Gly Ser Ser Val Pro Gly Ala Leu Asn Gln Arg
 1               5                  10                  15      
Ala Ala Glu Phe Glu Lys Pro Ala Ala Arg Gly Ser Ala Ala Ala Val
            20                  25                  30          
Pro Ser Ala Glu Val Arg Gly Gly Trp Gly Ala Glu Arg Ala Gly Trp
        35                  40                  45              
Gly Gly Ser Trp Ser Leu Ala Ser Arg Leu Gly Pro Val Ser Thr Ala
    50                  55                  60                  
Asn Met Ser Arg Pro Val Arg Asn Arg Lys Val Val Asp Tyr Ser Gln
65                  70                  75                  80  
Phe Gln Glu Ser Asp Asp Ala Asp Phe Glu Leu Arg Leu Leu Cys Ile
                85                  90                  95      
Cys Phe Phe Ala Ser Leu Tyr Ser Glu Asp Ser Glu Asp Lys Asp Val
            100                 105                 110         
Lys Thr Lys Lys Asp Asp Ser His Ser Ala Glu Asp Ser Glu Asp Glu
        115                 120                 125             
Lys Glu Asp His Lys Asn Val Arg Gln Gln Arg Gln Ala Ala Ser Lys
    130                 135                 140                 
Ala Ala Ser Lys Gln Arg Glu Met Leu Met Glu Asp Val Gly Ser Glu
145                 150                 155                 160 
Glu Glu Gln Glu Glu Glu Asp Glu Ala Pro Phe Gln Glu Lys Asp Ser
                165                 170                 175     
Gly Ser Asp Glu Asp Phe Leu Met Glu Asp Asp Asp Asp Ser Asp Tyr
            180                 185                 190         
Gly Ser Ser Lys Lys Lys Asn Lys Lys Met Val Lys Lys Ser Lys Pro
        195                 200                 205             
Glu Arg Lys Glu Lys Lys Met Pro Lys Pro Arg Leu Lys Ala Thr Val
    210                 215                 220                 
Thr Pro Ser Pro Val Lys Gly Lys Gly Lys Val Gly Arg Pro Thr Ala
225                 230                 235                 240 
Ser Lys Ala Ser Lys Glu Lys Thr Pro Ser Pro Lys Glu Glu Asp Glu
                245                 250                 255     
Glu Pro Glu Ser Pro Pro Glu Lys Lys Thr Ser Thr Ser Pro Pro Pro
            260                 265                 270         
Glu Lys Ser Gly Asp Glu Gly Ser Glu Asp Glu Ala Pro Ser Gly Glu
        275                 280                 285             
Asp
    


<210> 7419
<211> 1443
<212> PRT
<213> Homo sapiens

<400> 7419
Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu
 1               5                  10                  15      
Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala
            20                  25                  30          
His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr
        35                  40                  45              
Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln
    50                  55                  60                  
Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg
65                  70                  75                  80  
Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe
                85                  90                  95      
Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr
            100                 105                 110         
Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys
        115                 120                 125             
Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser
    130                 135                 140                 
Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu
145                 150                 155                 160 
Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala
                165                 170                 175     
Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro
            180                 185                 190         
Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu
        195                 200                 205             
Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg
    210                 215                 220                 
Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr
225                 230                 235                 240 
Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu
                245                 250                 255     
Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu
            260                 265                 270         
Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His
        275                 280                 285             
Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val
    290                 295                 300                 
Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro
305                 310                 315                 320 
Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala
                325                 330                 335     
Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly
            340                 345                 350         
Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser
        355                 360                 365             
Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile
    370                 375                 380                 
Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser
385                 390                 395                 400 
Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly
                405                 410                 415     
Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln
            420                 425                 430         
Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile
        435                 440                 445             
Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln
    450                 455                 460                 
Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly
465                 470                 475                 480 
Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp
                485                 490                 495     
Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu
            500                 505                 510         
Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr
        515                 520                 525             
Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser
    530                 535                 540                 
Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln
545                 550                 555                 560 
Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala
                565                 570                 575     
Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg
            580                 585                 590         
Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly
        595                 600                 605             
Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu
    610                 615                 620                 
Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu
625                 630                 635                 640 
Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr
                645                 650                 655     
Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg
            660                 665                 670         
Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn
        675                 680                 685             
Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val
    690                 695                 700                 
Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His
705                 710                 715                 720 
Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala
                725                 730                 735     
His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu
            740                 745                 750         
Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln
        755                 760                 765             
Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val
    770                 775                 780                 
Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu
785                 790                 795                 800 
Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser
                805                 810                 815     
Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu
            820                 825                 830         
Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly
        835                 840                 845             
Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn
    850                 855                 860                 
Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala
865                 870                 875                 880 
Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu
                885                 890                 895     
Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln
            900                 905                 910         
Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp
        915                 920                 925             
Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu
    930                 935                 940                 
Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Lys Pro Ser
945                 950                 955                 960 
Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser
                965                 970                 975     
Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser
            980                 985                 990         
His Val Ala Gln Ala Asn Leu Lys Leu Leu Asp Val Ser Lys Ile Phe
        995                 1000                1005            
Pro Ile Ala Glu Ile Ala Glu Glu Ser Ser Pro Glu Val Val Pro Val
    1010                1015                1020                
Glu Leu Leu Cys Val Pro Ser Pro Ala Ser Gln Gly Asp Leu His Thr
1025                1030                1035                1040
Lys Pro Leu Gly Thr Asp Asp Asp Phe Trp Gly Pro Thr Gly Pro Val
                1045                1050                1055    
Ala Thr Glu Val Val Asp Lys Glu Lys Asn Leu Tyr Arg Val His Phe
            1060                1065                1070        
Pro Val Ala Gly Ser Tyr Arg Trp Pro Asn Thr Gly Leu Cys Phe Val
        1075                1080                1085            
Met Arg Glu Ala Val Thr Val Glu Ile Glu Phe Cys Val Trp Asp Gln
    1090                1095                1100                
Phe Leu Gly Glu Ile Asn Pro Gln His Ser Trp Met Val Ala Gly Pro
1105                1110                1115                1120
Leu Leu Asp Ile Lys Ala Glu Pro Gly Ala Val Glu Ala Val His Leu
                1125                1130                1135    
Pro His Phe Val Ala Leu Gln Gly Gly His Val Asp Thr Ser Leu Phe
            1140                1145                1150        
Gln Met Ala His Phe Lys Glu Glu Gly Met Leu Leu Glu Lys Pro Ala
        1155                1160                1165            
Arg Val Glu Leu His His Ile Val Leu Glu Asn Pro Ser Phe Ser Pro
    1170                1175                1180                
Leu Gly Val Leu Leu Lys Met Ile His Asn Ala Leu Arg Phe Ile Pro
1185                1190                1195                1200
Val Thr Ser Val Val Leu Leu Tyr His Arg Val His Pro Glu Glu Val
                1205                1210                1215    
Thr Phe His Leu Tyr Leu Ile Pro Ser Asp Cys Ser Ile Arg Lys Ala
            1220                1225                1230        
Ile Asp Asp Leu Glu Met Lys Phe Gln Phe Val Arg Ile His Lys Pro
        1235                1240                1245            
Pro Pro Leu Thr Pro Leu Tyr Met Gly Cys Arg Tyr Thr Val Ser Gly
    1250                1255                1260                
Ser Gly Ser Gly Met Leu Glu Ile Leu Pro Lys Glu Leu Glu Leu Cys
1265                1270                1275                1280
Tyr Arg Ser Pro Gly Glu Asp Gln Leu Phe Ser Glu Phe Tyr Val Gly
                1285                1290                1295    
His Leu Gly Ser Gly Ile Arg Leu Gln Val Lys Asp Lys Lys Asp Glu
            1300                1305                1310        
Thr Leu Val Trp Glu Ala Leu Val Lys Pro Gly Asp Leu Met Pro Ala
        1315                1320                1325            
Thr Thr Leu Ile Pro Pro Ala Arg Ile Ala Val Pro Ser Pro Leu Asp
    1330                1335                1340                
Ala Pro Gln Leu Leu His Phe Val Asp Gln Tyr Arg Glu Gln Leu Ile
1345                1350                1355                1360
Ala Arg Val Thr Ser Val Glu Val Val Leu Asp Lys Leu His Gly Gln
                1365                1370                1375    
Val Leu Ser Gln Glu Gln Tyr Glu Arg Val Leu Ala Glu Asn Thr Arg
            1380                1385                1390        
Pro Ser Gln Met Arg Lys Leu Phe Ser Leu Ser Gln Ser Trp Asp Arg
        1395                1400                1405            
Lys Cys Lys Asp Gly Leu Tyr Gln Ala Leu Lys Glu Thr His Pro His
    1410                1415                1420                
Leu Ile Met Glu Leu Trp Glu Lys Gly Ser Lys Lys Gly Leu Leu Pro
1425                1430                1435                1440
Leu Ser Ser
            


<210> 7420
<211> 1399
<212> PRT
<213> Homo sapiens

<400> 7420
Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu
 1               5                  10                  15      
Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala
            20                  25                  30          
His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr
        35                  40                  45              
Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln
    50                  55                  60                  
Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg
65                  70                  75                  80  
Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe
                85                  90                  95      
Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr
            100                 105                 110         
Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys
        115                 120                 125             
Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser
    130                 135                 140                 
Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu
145                 150                 155                 160 
Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala
                165                 170                 175     
Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro
            180                 185                 190         
Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu
        195                 200                 205             
Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg
    210                 215                 220                 
Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr
225                 230                 235                 240 
Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu
                245                 250                 255     
Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu
            260                 265                 270         
Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His
        275                 280                 285             
Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val
    290                 295                 300                 
Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro
305                 310                 315                 320 
Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala
                325                 330                 335     
Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly
            340                 345                 350         
Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser
        355                 360                 365             
Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile
    370                 375                 380                 
Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser
385                 390                 395                 400 
Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly
                405                 410                 415     
Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln
            420                 425                 430         
Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile
        435                 440                 445             
Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln
    450                 455                 460                 
Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly
465                 470                 475                 480 
Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp
                485                 490                 495     
Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu
            500                 505                 510         
Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr
        515                 520                 525             
Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser
    530                 535                 540                 
Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln
545                 550                 555                 560 
Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala
                565                 570                 575     
Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg
            580                 585                 590         
Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly
        595                 600                 605             
Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu
    610                 615                 620                 
Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu
625                 630                 635                 640 
Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr
                645                 650                 655     
Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg
            660                 665                 670         
Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn
        675                 680                 685             
Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val
    690                 695                 700                 
Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His
705                 710                 715                 720 
Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala
                725                 730                 735     
His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu
            740                 745                 750         
Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln
        755                 760                 765             
Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val
    770                 775                 780                 
Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu
785                 790                 795                 800 
Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser
                805                 810                 815     
Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu
            820                 825                 830         
Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly
        835                 840                 845             
Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn
    850                 855                 860                 
Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala
865                 870                 875                 880 
Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu
                885                 890                 895     
Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln
            900                 905                 910         
Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp
        915                 920                 925             
Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu
    930                 935                 940                 
Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Lys Pro Ser
945                 950                 955                 960 
Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser
                965                 970                 975     
Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser
            980                 985                 990         
His Val Ala Gln Ala Asn Leu Lys Leu Leu Asp Val Ser Lys Ile Phe
        995                 1000                1005            
Pro Ile Ala Glu Ile Ala Glu Glu Ser Ser Pro Glu Val Val Pro Val
    1010                1015                1020                
Glu Leu Leu Cys Val Pro Ser Pro Ala Ser Gln Gly Asp Leu His Thr
1025                1030                1035                1040
Lys Pro Leu Gly Thr Asp Asp Asp Phe Trp Gly Pro Thr Gly Pro Val
                1045                1050                1055    
Ala Thr Glu Val Val Asp Lys Glu Lys Asn Leu Tyr Arg Val His Phe
            1060                1065                1070        
Pro Val Ala Gly Ser Tyr Arg Trp Pro Asn Thr Gly Leu Cys Phe Val
        1075                1080                1085            
Met Arg Glu Ala Val Thr Val Glu Ile Glu Phe Cys Val Trp Asp Gln
    1090                1095                1100                
Phe Leu Gly Glu Ile Asn Pro Gln His Ser Trp Met Val Ala Gly Pro
1105                1110                1115                1120
Leu Leu Asp Ile Lys Ala Glu Pro Gly Ala Val Glu Ala Val His Leu
                1125                1130                1135    
Pro His Phe Val Ala Leu Gln Gly Gly His Val Asp Thr Ser Leu Phe
            1140                1145                1150        
Gln Met Ala His Phe Lys Glu Glu Gly Met Leu Leu Glu Lys Pro Ala
        1155                1160                1165            
Arg Val Glu Leu His His Ile Val Leu Glu Asn Pro Ser Phe Ser Pro
    1170                1175                1180                
Leu Gly Val Leu Leu Lys Met Ile His Asn Ala Leu Arg Phe Ile Pro
1185                1190                1195                1200
Val Thr Ser Val Val Leu Leu Tyr His Arg Val His Pro Glu Glu Val
                1205                1210                1215    
Thr Phe His Leu Tyr Leu Ile Pro Ser Asp Cys Ser Ile Arg Lys Glu
            1220                1225                1230        
Leu Glu Leu Cys Tyr Arg Ser Pro Gly Glu Asp Gln Leu Phe Ser Glu
        1235                1240                1245            
Phe Tyr Val Gly His Leu Gly Ser Gly Ile Arg Leu Gln Val Lys Asp
    1250                1255                1260                
Lys Lys Asp Glu Thr Leu Val Trp Glu Ala Leu Val Lys Pro Gly Asp
1265                1270                1275                1280
Leu Met Pro Ala Thr Thr Leu Ile Pro Pro Ala Arg Ile Ala Val Pro
                1285                1290                1295    
Ser Pro Leu Asp Ala Pro Gln Leu Leu His Phe Val Asp Gln Tyr Arg
            1300                1305                1310        
Glu Gln Leu Ile Ala Arg Val Thr Ser Val Glu Val Val Leu Asp Lys
        1315                1320                1325            
Leu His Gly Gln Val Leu Ser Gln Glu Gln Tyr Glu Arg Val Leu Ala
    1330                1335                1340                
Glu Asn Thr Arg Pro Ser Gln Met Arg Lys Leu Phe Ser Leu Ser Gln
1345                1350                1355                1360
Ser Trp Asp Arg Lys Cys Lys Asp Gly Leu Tyr Gln Ala Leu Lys Glu
                1365                1370                1375    
Thr His Pro His Leu Ile Met Glu Leu Trp Glu Lys Gly Ser Lys Lys
            1380                1385                1390        
Gly Leu Leu Pro Leu Ser Ser
        1395                


<210> 7421
<211> 542
<212> PRT
<213> Homo sapiens

<400> 7421
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val
 1               5                  10                  15      
Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val
            20                  25                  30          
Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser
        35                  40                  45              
Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile
    50                  55                  60                  
Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser
65                  70                  75                  80  
Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala
                85                  90                  95      
Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn
            100                 105                 110         
Ile Leu Arg Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala
        115                 120                 125             
Leu Thr Glu Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser
    130                 135                 140                 
Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile
145                 150                 155                 160 
Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp
                165                 170                 175     
Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser
            180                 185                 190         
Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser
        195                 200                 205             
Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala
    210                 215                 220                 
Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe
225                 230                 235                 240 
Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp
                245                 250                 255     
Pro Asp Tyr Leu Pro Arg Thr Glu Met Asp Pro Lys Leu Arg Pro Ser
            260                 265                 270         
Phe Val Glu Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln
        275                 280                 285             
Glu Glu Glu Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly
    290                 295                 300                 
Leu Leu Glu Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp
305                 310                 315                 320 
Lys Ile Pro His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser
                325                 330                 335     
Arg Ser Gln Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser
            340                 345                 350         
Val Leu Asp Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro
        355                 360                 365             
Lys Val Asn Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile
    370                 375                 380                 
Lys Phe Phe Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp
385                 390                 395                 400 
Leu Asp Ala Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu
                405                 410                 415     
Pro Leu Ala Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro
            420                 425                 430         
Glu Phe Leu His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser
        435                 440                 445             
Leu Ser Asp Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val
    450                 455                 460                 
Lys Glu Ile Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala
465                 470                 475                 480 
His Glu Ala Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly
                485                 490                 495     
Ser Arg Pro Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu
            500                 505                 510         
Met Glu Val Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser
        515                 520                 525             
Thr Ser Gly Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly
    530                 535                 540         


<210> 7422
<211> 571
<212> PRT
<213> Homo sapiens

<400> 7422
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val
 1               5                  10                  15      
Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val
            20                  25                  30          
Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser
        35                  40                  45              
Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile
    50                  55                  60                  
Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser
65                  70                  75                  80  
Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala
                85                  90                  95      
Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn
            100                 105                 110         
Ile Leu Arg Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala
        115                 120                 125             
Leu Thr Glu Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser
    130                 135                 140                 
Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile
145                 150                 155                 160 
Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp
                165                 170                 175     
Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser
            180                 185                 190         
Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser
        195                 200                 205             
Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala
    210                 215                 220                 
Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe
225                 230                 235                 240 
Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp
                245                 250                 255     
Pro Asp Tyr Leu Pro Arg Thr Glu Asn Phe Gly Leu Asp Tyr Asp Ala
            260                 265                 270         
Phe Gln His Met Val Gly Asp Cys Pro Pro Asp Phe Leu Gln Leu Thr
        275                 280                 285             
Phe Asn Cys Cys Asn Met Asp Pro Lys Leu Arg Pro Ser Phe Val Glu
    290                 295                 300                 
Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln Glu Glu Glu
305                 310                 315                 320 
Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly Leu Leu Glu
                325                 330                 335     
Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp Lys Ile Pro
            340                 345                 350         
His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser Arg Ser Gln
        355                 360                 365             
Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser Val Leu Asp
    370                 375                 380                 
Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro Lys Val Asn
385                 390                 395                 400 
Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile Lys Phe Phe
                405                 410                 415     
Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp Leu Asp Ala
            420                 425                 430         
Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu Pro Leu Ala
        435                 440                 445             
Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro Glu Phe Leu
    450                 455                 460                 
His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser Leu Ser Asp
465                 470                 475                 480 
Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val Lys Glu Ile
                485                 490                 495     
Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala His Glu Ala
            500                 505                 510         
Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly Ser Arg Pro
        515                 520                 525             
Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu Met Glu Val
    530                 535                 540                 
Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser Thr Ser Gly
545                 550                 555                 560 
Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly
                565                 570     


<210> 7423
<211> 555
<212> PRT
<213> Homo sapiens

<400> 7423
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val
 1               5                  10                  15      
Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val
            20                  25                  30          
Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser
        35                  40                  45              
Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile
    50                  55                  60                  
Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser
65                  70                  75                  80  
Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala
                85                  90                  95      
Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn
            100                 105                 110         
Ile Leu Arg Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser
        115                 120                 125             
Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile
    130                 135                 140                 
Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp
145                 150                 155                 160 
Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser
                165                 170                 175     
Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser
            180                 185                 190         
Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala
        195                 200                 205             
Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe
    210                 215                 220                 
Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp
225                 230                 235                 240 
Pro Asp Tyr Leu Pro Arg Thr Glu Asn Phe Gly Leu Asp Tyr Asp Ala
                245                 250                 255     
Phe Gln His Met Val Gly Asp Cys Pro Pro Asp Phe Leu Gln Leu Thr
            260                 265                 270         
Phe Asn Cys Cys Asn Met Asp Pro Lys Leu Arg Pro Ser Phe Val Glu
        275                 280                 285             
Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln Glu Glu Glu
    290                 295                 300                 
Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly Leu Leu Glu
305                 310                 315                 320 
Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp Lys Ile Pro
                325                 330                 335     
His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser Arg Ser Gln
            340                 345                 350         
Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser Val Leu Asp
        355                 360                 365             
Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro Lys Val Asn
    370                 375                 380                 
Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile Lys Phe Phe
385                 390                 395                 400 
Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp Leu Asp Ala
                405                 410                 415     
Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu Pro Leu Ala
            420                 425                 430         
Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro Glu Phe Leu
        435                 440                 445             
His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser Leu Ser Asp
    450                 455                 460                 
Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val Lys Glu Ile
465                 470                 475                 480 
Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala His Glu Ala
                485                 490                 495     
Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly Ser Arg Pro
            500                 505                 510         
Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu Met Glu Val
        515                 520                 525             
Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser Thr Ser Gly
    530                 535                 540                 
Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly
545                 550                 555 


<210> 7424
<211> 341
<212> PRT
<213> Homo sapiens

<400> 7424
Met Ala Ala Leu Tyr Ala Cys Thr Lys Cys His Gln Arg Phe Pro Phe
 1               5                  10                  15      
Glu Ala Leu Ser Gln Gly Gln Gln Leu Cys Lys Glu Cys Arg Ile Ala
            20                  25                  30          
His Pro Val Val Lys Cys Thr Tyr Cys Arg Thr Glu Tyr Gln Gln Glu
        35                  40                  45              
Arg Leu Glu Cys Asn Gly Thr Ile Ser Ala His Cys Asn Leu His Leu
    50                  55                  60                  
Pro Gly Ser Ser Asp Ser Pro Ala Ser Ser Ser Arg Val Ala Gly Ile
65                  70                  75                  80  
Thr Gly Ile Lys Thr Asn Thr Ile Cys Lys Lys Cys Ala Gln Asn Val
                85                  90                  95      
Gln Leu Tyr Gly Thr Pro Lys Pro Cys Gln Tyr Cys Asn Ile Ile Ala
            100                 105                 110         
Ala Phe Ile Gly Asn Lys Cys Gln Arg Cys Thr Asn Ser Glu Lys Lys
        115                 120                 125             
Tyr Gly Pro Pro Tyr Ser Cys Glu Gln Cys Lys Gln Gln Cys Ala Phe
    130                 135                 140                 
Asp Arg Lys Asp Asp Arg Lys Lys Val Asp Gly Lys Leu Leu Cys Trp
145                 150                 155                 160 
Leu Cys Thr Leu Ser Tyr Lys Arg Val Leu Gln Lys Thr Lys Glu Gln
                165                 170                 175     
Arg Lys His Leu Ser Ser Ser Ser Arg Ala Gly His Gln Glu Lys Glu
            180                 185                 190         
Gln Tyr Ser Arg Leu Ser Gly Gly Gly His Tyr Asn Ser Gln Lys Thr
        195                 200                 205             
Leu Ser Thr Ser Ser Ile Gln Asn Glu Ile Pro Lys Lys Lys Ser Lys
    210                 215                 220                 
Phe Glu Ser Ile Thr Thr Asn Gly Asp Ser Phe Ser Pro Asp Leu Ala
225                 230                 235                 240 
Leu Asp Ser Pro Gly Thr Asp His Phe Val Ile Ile Ala Gln Leu Lys
                245                 250                 255     
Glu Glu Val Ala Thr Leu Lys Lys Met Leu His Gln Lys Asp Gln Met
            260                 265                 270         
Ile Leu Glu Lys Glu Lys Lys Ile Thr Glu Leu Lys Ala Asp Phe Gln
        275                 280                 285             
Tyr Gln Glu Ser Gln Met Arg Ala Lys Met Asn Gln Met Glu Lys Thr
    290                 295                 300                 
His Lys Glu Val Thr Glu Gln Leu Gln Ala Lys Asn Arg Glu Leu Leu
305                 310                 315                 320 
Lys Gln Ala Ala Ala Leu Ser Lys Ser Lys Lys Ser Glu Lys Ser Gly
                325                 330                 335     
Ala Ile Thr Ser Pro
            340     


<210> 7425
<211> 312
<212> PRT
<213> Homo sapiens

<400> 7425
Met Ala Ala Leu Tyr Ala Cys Thr Lys Cys His Gln Arg Phe Pro Phe
 1               5                  10                  15      
Glu Ala Leu Ser Gln Gly Gln Gln Leu Cys Lys Glu Cys Arg Ile Ala
            20                  25                  30          
His Pro Val Val Lys Cys Thr Tyr Cys Arg Thr Glu Tyr Gln Gln Glu
        35                  40                  45              
Arg Leu Glu Cys Asn Gly Thr Ile Ser Ala His Cys Asn Leu His Leu
    50                  55                  60                  
Pro Gly Ser Ser Asp Ser Pro Ala Ser Ser Ser Arg Val Ala Gly Ile
65                  70                  75                  80  
Thr Gly Ile Lys Thr Asn Thr Ile Cys Lys Lys Cys Ala Gln Asn Val
                85                  90                  95      
Gln Leu Tyr Gly Thr Pro Lys Pro Cys Gln Tyr Cys Asn Ile Ile Ala
            100                 105                 110         
Ala Phe Ile Gly Asn Lys Cys Gln Arg Cys Thr Asn Ser Glu Lys Lys
        115                 120                 125             
Tyr Gly Pro Pro Tyr Ser Cys Glu Gln Cys Lys Gln Gln Cys Ala Phe
    130                 135                 140                 
Asp Arg Lys Asp Asp Arg Lys Lys Val Asp Gly Lys Leu Leu Cys Trp
145                 150                 155                 160 
Leu Cys Thr Leu Ser Tyr Lys Arg Val Leu Gln Lys Thr Lys Glu Gln
                165                 170                 175     
Arg Lys His Leu Ser Ser Ser Ser Arg Ala Gly His Gln Glu Lys Glu
            180                 185                 190         
Gln Tyr Ser Arg Leu Ser Gly Gly Gly His Tyr Asn Ser Phe Ser Pro
        195                 200                 205             
Asp Leu Ala Leu Asp Ser Pro Gly Thr Asp His Phe Val Ile Ile Ala
    210                 215                 220                 
Gln Leu Lys Glu Glu Val Ala Thr Leu Lys Lys Met Leu His Gln Lys
225                 230                 235                 240 
Asp Gln Met Ile Leu Glu Lys Glu Lys Lys Ile Thr Glu Leu Lys Ala
                245                 250                 255     
Asp Phe Gln Tyr Gln Glu Ser Gln Met Arg Ala Lys Met Asn Gln Met
            260                 265                 270         
Glu Lys Thr His Lys Glu Val Thr Glu Gln Leu Gln Ala Lys Asn Arg
        275                 280                 285             
Glu Leu Leu Lys Gln Ala Ala Ala Leu Ser Lys Ser Lys Lys Ser Glu
    290                 295                 300                 
Lys Ser Gly Ala Ile Thr Ser Pro
305                 310         


<210> 7426
<211> 321
<212> PRT
<213> Homo sapiens

<400> 7426
Met Asn Arg Gly Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu
 1               5                  10                  15      
Cys Thr Asn Cys Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val
            20                  25                  30          
Ser Gln Pro Leu Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu
        35                  40                  45              
Val Val Gln Ala Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu
    50                  55                  60                  
Glu Tyr Ser Thr Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser
65                  70                  75                  80  
Leu His Thr Gln Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met
                85                  90                  95      
Leu Arg Met Asp Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala
            100                 105                 110         
Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His
        115                 120                 125             
Val Asp Glu Phe Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly
    130                 135                 140                 
Leu Glu Tyr Val Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys
145                 150                 155                 160 
Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys
                165                 170                 175     
Leu Val Lys Thr Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His
            180                 185                 190         
Ala Val Val Leu Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe
        195                 200                 205             
Gly Ser Gly Ile Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe
    210                 215                 220                 
Arg Leu Ile Ser Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp
225                 230                 235                 240 
Asn Asn Ile Glu Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val
                245                 250                 255     
Asp Ser Leu Ser Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu
            260                 265                 270         
Gln Glu Glu Arg Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr
        275                 280                 285             
Arg Phe Glu Lys Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp
    290                 295                 300                 
Thr Phe His Ser Phe Pro His Ser Gly Ala Phe Leu His Phe Phe Ala
305                 310                 315                 320 
Phe
    


<210> 7427
<211> 317
<212> PRT
<213> Homo sapiens

<400> 7427
Met Asn Arg Gly Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu
 1               5                  10                  15      
Cys Thr Asn Cys Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val
            20                  25                  30          
Ser Gln Pro Leu Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu
        35                  40                  45              
Val Val Gln Ala Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu
    50                  55                  60                  
Glu Tyr Ser Thr Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser
65                  70                  75                  80  
Leu His Thr Gln Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met
                85                  90                  95      
Leu Arg Met Asp Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala
            100                 105                 110         
Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His
        115                 120                 125             
Val Asp Glu Phe Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly
    130                 135                 140                 
Leu Glu Tyr Val Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys
145                 150                 155                 160 
Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys
                165                 170                 175     
Leu Val Lys Thr Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His
            180                 185                 190         
Ala Val Val Leu Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe
        195                 200                 205             
Gly Ser Gly Ile Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe
    210                 215                 220                 
Arg Leu Ile Ser Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp
225                 230                 235                 240 
Asn Asn Ile Glu Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val
                245                 250                 255     
Asp Ser Leu Ser Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu
            260                 265                 270         
Gln Glu Glu Arg Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr
        275                 280                 285             
Arg Phe Glu Lys Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp
    290                 295                 300                 
Thr Phe His Ser Phe Pro His Ser Gly Leu Leu Lys Tyr
305                 310                 315         


<210> 7428
<211> 492
<212> PRT
<213> Homo sapiens

<400> 7428
Met Asn Arg Gly Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu
 1               5                  10                  15      
Cys Thr Asn Cys Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val
            20                  25                  30          
Ser Gln Pro Leu Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu
        35                  40                  45              
Val Val Gln Ala Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu
    50                  55                  60                  
Glu Tyr Ser Thr Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser
65                  70                  75                  80  
Leu His Thr Gln Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met
                85                  90                  95      
Leu Arg Met Asp Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala
            100                 105                 110         
Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His
        115                 120                 125             
Val Asp Glu Phe Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly
    130                 135                 140                 
Leu Glu Tyr Val Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys
145                 150                 155                 160 
Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys
                165                 170                 175     
Leu Val Lys Thr Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His
            180                 185                 190         
Ala Val Val Leu Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe
        195                 200                 205             
Gly Ser Gly Ile Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe
    210                 215                 220                 
Arg Leu Ile Ser Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp
225                 230                 235                 240 
Asn Asn Ile Glu Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val
                245                 250                 255     
Asp Ser Leu Ser Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu
            260                 265                 270         
Gln Glu Glu Arg Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr
        275                 280                 285             
Arg Phe Glu Lys Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp
    290                 295                 300                 
Thr Phe His Ser Phe Pro His Ser Asp Phe Glu Asp Asp Met Ile Ile
305                 310                 315                 320 
Thr Ser Asp Val Ser Arg Tyr Ile Glu Asp Pro Gly Phe Gly Tyr Glu
                325                 330                 335     
Asp Phe Ala Arg Arg Gly Glu Glu His Leu Pro Thr Phe Arg Ala Gln
            340                 345                 350         
Asp Tyr Thr Trp Glu Asn His Gly Phe Ser Leu Val Asn Arg Leu Tyr
        355                 360                 365             
Ser Asp Ile Gly His Leu Leu Asp Glu Lys Phe Arg Met Val Tyr Asn
    370                 375                 380                 
Leu Thr Tyr Asn Thr Met Ala Thr His Glu Asp Val Asp Thr Thr Met
385                 390                 395                 400 
Leu Arg Arg Ala Leu Phe Asn Tyr Val His Cys Met Phe Gly Ile Arg
                405                 410                 415     
Tyr Asp Asp Tyr Asp Tyr Gly Glu Val Asn Gln Leu Leu Glu Arg Ser
            420                 425                 430         
Leu Lys Val Tyr Ile Lys Thr Val Thr Cys Tyr Pro Glu Arg Thr Thr
        435                 440                 445             
Lys Arg Met Tyr Asp Ser Tyr Trp Arg Gln Phe Lys His Ser Glu Lys
    450                 455                 460                 
Val His Val Asn Leu Leu Leu Met Glu Ala Arg Met Gln Ala Glu Leu
465                 470                 475                 480 
Leu Tyr Ala Leu Arg Ala Ile Thr Arg His Leu Thr
                485                 490         


<210> 7429
<211> 1211
<212> PRT
<213> Homo sapiens

<400> 7429
Met Leu Ser Leu Ala Ala Lys Leu Val Ala Phe Phe Trp Arg Thr Ala
 1               5                  10                  15      
Asp Thr Pro Arg Glu Glu Ala Gly Gln Leu Glu Pro Glu Leu Ala Glu
            20                  25                  30          
Gly Asp Thr Lys Leu Lys Thr Val Arg Gly Val Val Thr Arg Tyr Cys
        35                  40                  45              
Ser Asp Tyr Gly Met Ile Asp Asp Met Ile Tyr Phe Ser Ser Asp Ala
    50                  55                  60                  
Val Thr Ser Arg Val Leu Leu Asn Val Gly Gln Glu Val Ile Ala Val
65                  70                  75                  80  
Val Glu Glu Asn Lys Val Ser Asn Gly Leu Lys Ala Ile Arg Val Glu
                85                  90                  95      
Ala Val Ser Asp Lys Trp Glu Asp Asp Ser Arg Asn His Gly Ser Pro
            100                 105                 110         
Ser Asp Cys Gly Pro Arg Val Leu Ile Gly Cys Val Thr Ser Leu Val
        115                 120                 125             
Glu Gly Ala Gly Cys Ile Ser Gln Thr Thr Tyr Phe Ser Leu Glu Ser
    130                 135                 140                 
Val Cys Glu Gly Phe Glu Pro Cys Lys Gly Asp Trp Val Glu Ala Glu
145                 150                 155                 160 
Tyr Arg Ile Arg Pro Gly Thr Trp Ser Ser Glu Ala Thr Ser Val Lys
                165                 170                 175     
Pro Leu Arg Tyr Lys Arg Val Asp Lys Val Cys Ile Ser Ser Leu Cys
            180                 185                 190         
Gly Arg Asn Gly Val Leu Glu Glu Ser Ile Phe Phe Thr Leu Asp Ser
        195                 200                 205             
Leu Lys Leu Pro Asp Gly Tyr Thr Pro Arg Arg Gly Asp Val Val Asn
    210                 215                 220                 
Ala Val Val Val Glu Ser Ser Gln Ser Cys Tyr Val Trp Arg Ala Leu
225                 230                 235                 240 
Cys Met Thr Leu Val Lys Arg Arg Asp Ala Ala Pro Val His Glu Ala
                245                 250                 255     
Thr His Phe Tyr Gly Thr Ile Leu Leu Lys Asn Lys Gly Asp Ile Glu
            260                 265                 270         
Val Thr Gln Val Thr His Phe Gly Thr Leu Lys Glu Gly Arg Ser Lys
        275                 280                 285             
Thr Met Val Ile Trp Ile Glu Asn Lys Gly Asp Ile Pro Gln Asn Leu
    290                 295                 300                 
Val Ser Cys Lys Leu Ala Gly Trp Asp Lys Ser Lys Gln Phe Arg Phe
305                 310                 315                 320 
Gln Met Leu Asp Lys Asp Gln Met Cys Pro Val Val Ser Phe Val Ser
                325                 330                 335     
Val Pro Glu Lys Glu Asn Ser Ser Asp Glu Asn Ile Asn Ser Leu Asn
            340                 345                 350         
Ser His Thr Lys Asn Lys Thr Ser Gln Met Ser Glu Ser Ser Leu Val
        355                 360                 365             
Asn Asn Arg Gly Ile Ser Pro Gly Asp Cys Thr Cys Lys Gly Glu Asn
    370                 375                 380                 
Gly Glu Lys Asp Asn Ile Leu Ser Arg Lys Gln Met Thr Glu Pro Glu
385                 390                 395                 400 
Pro Gly Gly Leu Val Pro Pro Gly Gly Lys Thr Phe Ile Val Val Ile
                405                 410                 415     
Cys Asp Gly Lys Asn Pro Gly Arg Cys Lys Glu Leu Leu Leu Leu Cys
            420                 425                 430         
Phe Ser Asp Phe Leu Ile Gly Arg Tyr Leu Glu Val Asn Val Ile Ser
        435                 440                 445             
Gly Glu Glu Ser Leu Ile Ala Ala Arg Glu Pro Phe Ser Trp Lys Lys
    450                 455                 460                 
Leu Lys Ser Ser Gln Ala Leu Thr Ser Ala Lys Thr Thr Val Val Val
465                 470                 475                 480 
Thr Ala Gln Lys Arg Asn Ser Arg Arg Gln Leu Pro Ser Phe Leu Pro
                485                 490                 495     
Gln Tyr Pro Ile Pro Asp Arg Leu Arg Lys Cys Val Glu Gln Lys Ile
            500                 505                 510         
Asp Ile Leu Thr Phe Gln Pro Leu Leu Ala Glu Leu Leu Asn Met Ser
        515                 520                 525             
Asn Tyr Lys Glu Lys Phe Ser Thr Leu Leu Trp Leu Glu Glu Ile Tyr
    530                 535                 540                 
Ala Glu Met Glu Leu Lys Glu Tyr Asn Met Ser Gly Ile Ile Leu Arg
545                 550                 555                 560 
Arg Asn Gly Asp Leu Leu Val Leu Glu Val Pro Gly Leu Ala Glu Gly
                565                 570                 575     
Arg Pro Ser Leu Tyr Ala Gly Asp Lys Leu Ile Leu Lys Thr Gln Glu
            580                 585                 590         
Tyr Asn Gly His Ala Ile Glu Tyr Ile Ser Tyr Val Thr Glu Ile His
        595                 600                 605             
Glu Glu Asp Val Thr Leu Lys Ile Asn Pro Glu Phe Glu Gln Ala Tyr
    610                 615                 620                 
Asn Phe Glu Pro Met Asp Val Glu Phe Thr Tyr Asn Arg Thr Thr Ser
625                 630                 635                 640 
Arg Arg Cys His Phe Ala Leu Glu His Val Ile His Leu Gly Val Lys
                645                 650                 655     
Val Leu Phe Pro Glu Glu Ile Ile Leu Gln Ser Pro Gln Val Thr Gly
            660                 665                 670         
Asn Trp Asn His Ala Gln Asp Thr Lys Ser Ser Gly Gln Ser Thr Ser
        675                 680                 685             
Lys Lys Asn Arg Lys Thr Met Thr Asp Gln Ala Glu His Gly Thr Glu
    690                 695                 700                 
Glu Arg Arg Val Gly Asp Lys Asp Leu Pro Val Leu Ala Pro Phe Thr
705                 710                 715                 720 
Ala Glu Met Ser Asp Trp Val Asp Glu Ile Gln Thr Pro Lys Ala Arg
                725                 730                 735     
Lys Met Glu Phe Phe Asn Pro Val Leu Asn Glu Asn Gln Lys Leu Ala
            740                 745                 750         
Val Lys Arg Ile Leu Ser Gly Asp Cys Arg Pro Leu Pro Tyr Ile Leu
        755                 760                 765             
Phe Gly Pro Pro Gly Thr Gly Lys Thr Val Thr Ile Ile Glu Ala Val
    770                 775                 780                 
Leu Gln Val His Phe Ala Leu Pro Asp Ser Arg Ile Leu Val Cys Ala
785                 790                 795                 800 
Pro Ser Asn Ser Ala Ala Asp Leu Val Cys Leu Arg Leu His Glu Ser
                805                 810                 815     
Lys Val Leu Gln Pro Ala Thr Met Val Arg Val Asn Ala Thr Cys Arg
            820                 825                 830         
Phe Glu Glu Ile Val Ile Asp Ala Val Lys Pro Tyr Cys Arg Asp Gly
        835                 840                 845             
Glu Asp Ile Trp Lys Ala Ser Arg Phe Arg Ile Ile Ile Thr Thr Cys
    850                 855                 860                 
Ser Ser Ser Gly Leu Phe Tyr Gln Ile Gly Val Arg Val Gly His Phe
865                 870                 875                 880 
Thr His Val Phe Val Asp Glu Ala Gly Gln Ala Ser Glu Pro Glu Cys
                885                 890                 895     
Leu Ile Pro Leu Gly Leu Met Ser Asp Ile Ser Gly Gln Ile Val Leu
            900                 905                 910         
Ala Gly Asp Pro Met Gln Leu Gly Pro Val Ile Lys Ser Arg Leu Ala
        915                 920                 925             
Met Ala Tyr Gly Leu Asn Val Ser Phe Leu Glu Arg Leu Met Ser Arg
    930                 935                 940                 
Pro Ala Tyr Gln Arg Asp Glu Asn Ala Phe Gly Ala Cys Gly Ala His
945                 950                 955                 960 
Asn Pro Leu Leu Val Thr Lys Leu Val Lys Asn Tyr Arg Ser His Glu
                965                 970                 975     
Ala Leu Leu Met Leu Pro Ser Arg Leu Phe Tyr His Arg Glu Leu Glu
            980                 985                 990         
Val Cys Ala Asp Pro Thr Val Val Thr Ser Leu Leu Gly Trp Glu Lys
        995                 1000                1005            
Leu Pro Lys Lys Gly Phe Pro Leu Ile Phe His Gly Val Arg Gly Ser
    1010                1015                1020                
Glu Ala Arg Glu Gly Lys Ser Pro Ser Trp Phe Asn Pro Ala Glu Ala
1025                1030                1035                1040
Val Gln Val Leu Arg Tyr Cys Cys Leu Leu Ala His Ser Ile Ser Ser
                1045                1050                1055    
Gln Val Ser Ala Ser Asp Ile Gly Val Ile Thr Pro Tyr Arg Lys Gln
            1060                1065                1070        
Val Glu Lys Ile Arg Ile Leu Leu Arg Asn Val Asp Leu Met Asp Ile
        1075                1080                1085            
Lys Val Gly Ser Val Glu Glu Phe Gln Gly Gln Glu Tyr Leu Val Ile
    1090                1095                1100                
Ile Ile Ser Thr Val Arg Ser Asn Glu Asp Arg Phe Glu Asp Asp Arg
1105                1110                1115                1120
Tyr Phe Leu Gly Phe Leu Ser Asn Ser Lys Arg Phe Asn Val Ala Ile
                1125                1130                1135    
Thr Arg Pro Lys Ala Leu Leu Ile Val Leu Gly Asn Pro His Val Leu
            1140                1145                1150        
Val Arg Asp Pro Cys Phe Gly Ala Leu Leu Glu Tyr Ser Ile Thr Asn
        1155                1160                1165            
Gly Val Tyr Met Gly Cys Asp Leu Pro Pro Ala Leu Gln Ser Leu Gln
    1170                1175                1180                
Asn Cys Gly Glu Gly Val Ala Asp Pro Ser Tyr Pro Val Val Pro Glu
1185                1190                1195                1200
Ser Thr Gly Pro Glu Lys His Gln Glu Pro Ser
                1205                1210    


<210> 7430
<211> 338
<212> PRT
<213> Homo sapiens

<400> 7430
Met Phe Arg Val Gly His Phe Thr His Val Phe Val Asp Glu Ala Gly
 1               5                  10                  15      
Gln Ala Ser Glu Pro Glu Cys Leu Ile Pro Leu Gly Leu Met Ser Asp
            20                  25                  30          
Ile Ser Gly Gln Ile Val Leu Ala Gly Asp Pro Met Gln Leu Gly Pro
        35                  40                  45              
Val Ile Lys Ser Arg Leu Ala Met Ala Tyr Gly Leu Asn Val Ser Phe
    50                  55                  60                  
Leu Glu Arg Leu Met Ser Arg Pro Ala Tyr Gln Arg Asp Glu Asn Ala
65                  70                  75                  80  
Phe Gly Ala Cys Gly Ala His Asn Pro Leu Leu Val Thr Lys Leu Val
                85                  90                  95      
Lys Asn Tyr Arg Ser His Glu Ala Leu Leu Met Leu Pro Ser Arg Leu
            100                 105                 110         
Phe Tyr His Arg Glu Leu Glu Val Cys Ala Asp Pro Thr Val Val Thr
        115                 120                 125             
Ser Leu Leu Gly Trp Glu Lys Leu Pro Lys Lys Gly Phe Pro Leu Ile
    130                 135                 140                 
Phe His Gly Val Arg Gly Ser Glu Ala Arg Glu Gly Lys Ser Pro Ser
145                 150                 155                 160 
Trp Phe Asn Pro Ala Glu Ala Val Gln Val Leu Arg Tyr Cys Cys Leu
                165                 170                 175     
Leu Ala His Ser Ile Ser Ser Gln Val Ser Ala Ser Asp Ile Gly Val
            180                 185                 190         
Ile Thr Pro Tyr Arg Lys Gln Val Glu Lys Ile Arg Ile Leu Leu Arg
        195                 200                 205             
Asn Val Asp Leu Met Asp Ile Lys Val Gly Ser Val Glu Glu Phe Gln
    210                 215                 220                 
Gly Gln Glu Tyr Leu Val Ile Ile Ile Ser Thr Val Arg Ser Asn Glu
225                 230                 235                 240 
Asp Arg Phe Glu Asp Asp Arg Tyr Phe Leu Gly Phe Leu Ser Asn Ser
                245                 250                 255     
Lys Arg Phe Asn Val Ala Ile Thr Arg Pro Lys Ala Leu Leu Ile Val
            260                 265                 270         
Leu Gly Asn Pro His Val Leu Val Arg Asp Pro Cys Phe Gly Ala Leu
        275                 280                 285             
Leu Glu Tyr Ser Ile Thr Asn Gly Val Tyr Met Gly Cys Asp Leu Pro
    290                 295                 300                 
Pro Ala Leu Gln Ser Leu Gln Asn Cys Gly Glu Gly Val Ala Asp Pro
305                 310                 315                 320 
Ser Tyr Pro Val Val Pro Glu Ser Thr Gly Pro Glu Lys His Gln Glu
                325                 330                 335     
Pro Ser
        


<210> 7431
<211> 1254
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 956
<223> Xaa = Any Amino Acid

<400> 7431
Met Leu Leu Pro Asp Ala Ser Pro Lys Gln Ser Gln Arg Arg Val Leu
 1               5                  10                  15      
Trp Ala Glu Pro Pro Cys Ser Tyr Asn Leu Thr Glu Ala Glu Val Ala
            20                  25                  30          
Val Lys Lys Lys Lys Asn Pro His Thr Pro Leu Leu Trp Ser Leu Pro
        35                  40                  45              
Ser Arg Ile Ser Glu Pro Ala Arg Ala Met Thr Cys Asn Thr Ser Val
    50                  55                  60                  
Thr Arg Arg Cys Pro Lys Ile Pro Pro Trp His Leu Asp Arg Lys Tyr
65                  70                  75                  80  
Gly Ser Cys Ser Thr Ile Leu Leu Asp Asn Ser Thr Ala Ser Gln Pro
                85                  90                  95      
Asp Leu Arg His Thr Leu Glu Arg Tyr Ala Asn Arg Ser Leu Ala Ile
            100                 105                 110         
Phe Glu Glu Pro Val His Pro Leu Pro Gln Glu Lys Leu Pro Gly Lys
        115                 120                 125             
Ser Phe Lys His Asp Pro Lys Arg Asn Cys Ile Phe Arg His Phe Cys
    130                 135                 140                 
Thr Leu Phe Gln Val Ile Lys Leu Thr Ala Pro Cys Ala Ile Val Ala
145                 150                 155                 160 
Leu Val Tyr Ile Lys Arg Leu Leu Thr Ser Ala Asn Ile Asp Leu Cys
                165                 170                 175     
Pro Thr Asn Trp Lys Lys Ile Val Leu Gly Thr Met Leu Leu Ala Ser
            180                 185                 190         
Lys Val Trp Arg Asn His Gly Leu Trp Ser Val Asp Asp Ser Gln Asn
        195                 200                 205             
Ser Lys Asp Thr Ala Val Glu Asn Ile Cys Thr Asn Met Thr Leu Lys
    210                 215                 220                 
Arg Ser Phe Thr Arg Ala Pro Phe Gln Ser Asp Leu Met Thr Ala Val
225                 230                 235                 240 
Lys Gly Arg Asp Leu Gln Leu Ala Gly Arg Glu Ser Arg Glu Ala Phe
                245                 250                 255     
Pro Ala Glu Pro Ser Trp Val Pro Ala Arg Gln Ser Lys Met Glu Lys
            260                 265                 270         
Cys Phe Leu Glu Leu Leu Glu Phe Asn Ile His Val Ser Ala Ser Val
        275                 280                 285             
Tyr Ala Lys Tyr Tyr Phe Asp Leu Cys Ala Leu Ala Asn Asp His Asp
    290                 295                 300                 
Leu Tyr Phe Leu Phe Ser Phe Leu His Lys Asp Lys Ala Gln Lys Leu
305                 310                 315                 320 
Glu Leu Leu Asn Gln Pro Thr Arg Ala Pro Gly Ala Val Arg Gly Pro
                325                 330                 335     
Ala Ala Pro Ala Pro Glu Val Asp Asn Phe Ala Pro Glu Arg Ala Ala
            340                 345                 350         
Thr Val Thr Leu Arg Lys Glu Val Thr Val Arg Ala Pro Ala Gly Gly
        355                 360                 365             
Ser Arg Asn Gln Arg Pro Gln Leu Ala Ser Arg Pro Arg Arg Gln Arg
    370                 375                 380                 
Arg Cys Ser Val Pro Val Ile Gly Arg Leu Gly Gln Pro Leu Arg Ala
385                 390                 395                 400 
Trp Ala Gln Leu Tyr Ile Ser Cys Cys Gln Ser Ser Ser Ala Gln Pro
                405                 410                 415     
Ser Gly Val Glu Ala Glu Gln Arg Thr Pro Ile Gln Gly Ala Tyr Ala
            420                 425                 430         
Val Ser Gln Ser Pro Arg Pro Ser Ile Phe Arg Gly Ala Ser Thr Pro
        435                 440                 445             
Asn Ala Gly Phe Ser Cys His Pro Val Ala Leu Pro Gly Val Ala Pro
    450                 455                 460                 
Phe Trp Gly Tyr Arg Glu Ile Gly Pro Ser Ala Asp Ser Cys Val Phe
465                 470                 475                 480 
Trp Tyr Pro Gly Ala Thr Gly Ala Ser Trp Pro Ile Ala Val Leu Leu
                485                 490                 495     
Ala Asn Leu Gln Pro Asp Ala Arg Gln Gly Glu Cys Thr Leu Pro Gly
            500                 505                 510         
Ala Ala Leu Gly His Thr Ser Gln His Ser Leu Ser Leu Gly Pro Cys
        515                 520                 525             
Arg Val Leu Gly Ala Leu Ser Leu Ala Glu Val Leu Pro Gln Glu Ile
    530                 535                 540                 
Lys Gln Glu Ile His Gln Val Leu Met Asp His Gly Val Pro Cys His
545                 550                 555                 560 
Tyr Thr Cys Phe Leu Leu His Pro Glu Asp Ser Thr Leu Glu Arg Phe
                565                 570                 575     
Leu Val Leu His Ser Ile Gln Gly Leu Gln Glu Asp Ser Val Leu Cys
            580                 585                 590         
Lys Val Glu Ile His Gly Leu Ser Pro Gln Pro Gln Thr Tyr Gln Ser
        595                 600                 605             
His Phe Arg Ser Pro Ser Leu Ala Glu Leu Leu Asn Arg Ile Ser Gly
    610                 615                 620                 
Thr Cys Arg Asn His Phe Ala Gly Met Gln Lys Lys Ser Ser Ala Ser
625                 630                 635                 640 
Met Gly Glu Gly Ser Leu Gly Arg Gly Ala His Leu Leu Leu Ser Asp
                645                 650                 655     
Phe Arg Ala Val Ser Gln Gly Val Lys Asn Pro Gln Gln Gly Gly Leu
            660                 665                 670         
Gly Ala Glu Gly Val His Gly Arg Ala Leu Ser Phe Val Gly Cys Pro
        675                 680                 685             
Ile Ser Pro Ser Pro Thr Cys His Ser Val Gln Arg Asn Gly His Leu
    690                 695                 700                 
Val Leu Asp Val Gln Leu Asp Asp Pro Lys Gly Glu His Asn Met Asp
705                 710                 715                 720 
Cys Val Cys Thr Gln Glu Thr Ser Thr Ser Arg Leu Gly Cys Lys Glu
                725                 730                 735     
His Ile Ser Gly Leu Gly Pro Gly Ala Ser Pro Cys Ala His Gln Ala
            740                 745                 750         
Pro Pro Ser Leu Leu Gly Ala Arg Arg Phe Cys Ser Leu Ser Cys Ser
        755                 760                 765             
Leu His Ala Gly Leu Phe Ile Arg Ala Ser Gly Pro Val His Gly Glu
    770                 775                 780                 
Val Glu Glu Arg Thr Ser Gln Arg Arg Ser Gln Pro Trp Pro Thr Thr
785                 790                 795                 800 
Gln Gln Ser Pro Gln Asp Glu Gln Glu Lys Leu Leu Asp Glu Ala Ile
                805                 810                 815     
Gln Ala Val Lys Val Gln Ser Phe Gln Met Lys Arg Phe Leu Val Tyr
            820                 825                 830         
Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala Asp Leu Tyr Glu
        835                 840                 845             
Leu Val Gln Tyr Ala Gly Asn Ile Ile Pro Arg Leu Tyr Leu Leu Ile
    850                 855                 860                 
Thr Val Gly Val Val Tyr Ala Lys Ser Phe Pro Gln Ser Arg Lys Asp
865                 870                 875                 880 
Ile Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val Gln His Pro Leu
                885                 890                 895     
Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gln Cys Thr Arg Asn Ile
            900                 905                 910         
Leu Leu Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr Thr Ser Asn Ile
        915                 920                 925             
Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala Glu Met Asn Lys
    930                 935                 940                 
Phe Trp Val Arg Met Gln His Gln Gly His Ser Xaa Asp Arg Glu Lys
945                 950                 955                 960 
Arg Glu Arg Glu Arg Gln Glu Leu Arg Ile Leu Val Gly Thr His Leu
                965                 970                 975     
Val His Leu Ser Gln Leu Glu Gly Val Asn Val Glu His Tyr Lys Gln
            980                 985                 990         
Ile Val Leu Ser Gly Ile Leu Glu Gln Val Val Asn Cys Arg Asp Thr
        995                 1000                1005            
Leu Ala Gln Glu Tyr Leu Met Arg Cys Val Ile Gln Val Phe Pro Asp
    1010                1015                1020                
Glu Phe His Leu Gln Thr Leu Asn Pro Phe Leu Arg Thr Cys Ala Glu
1025                1030                1035                1040
Leu His Gln Asn Val Asn Val Lys Asn Ile Ile Ile Ala Leu Ile Asp
                1045                1050                1055    
Ser Phe Ile Cys His Cys Glu Asp Gly Pro Gly Ile Pro Ala Asp Ile
            1060                1065                1070        
Lys Leu Phe Asp Ile Phe Ser Gln Gln Val Ala Thr Val Ile Gln Ser
        1075                1080                1085            
Arg Gln Asp Met Pro Ser Glu Asp Val Leu Ser Leu Gln Val Ser Leu
    1090                1095                1100                
Val Asn Leu Asp Met Lys Cys Tyr Pro Asp Arg Val Asp Tyr Ile Asp
1105                1110                1115                1120
Lys Val Leu Glu Thr Ala Ala Glu Ile Phe Asn Lys Leu Asn Leu Glu
                1125                1130                1135    
His Leu Glu Ile Lys Thr Phe His Pro Leu Phe Glu Tyr Phe Asp Tyr
            1140                1145                1150        
Glu Ser Arg Lys Ser Met Ser Cys Tyr Val Leu Ser Ser Val Leu Asp
        1155                1160                1165            
Tyr Asn Thr Glu Ile Val Ser Gln Asp Gln Val Asp Ser Ile Met Asn
    1170                1175                1180                
Leu Val Ser Thr Leu Ile Gln Asp Gln Pro Asp Gln Pro Val Glu Asp
1185                1190                1195                1200
Pro Asp Pro Glu Asp Phe Ala Asp Glu Gln Ser Val Val Gly Pro Ser
                1205                1210                1215    
Phe Ile Cys Cys Ala Leu Arg Thr Leu Thr Ser Ser Thr Trp Tyr Glu
            1220                1225                1230        
Phe Thr Leu Thr Ile Thr Leu Cys Gln Leu Leu Val Lys Ser His Val
        1235                1240                1245            
Glu Val Leu Lys Met Val
    1250                


<210> 7432
<211> 209
<212> PRT
<213> Homo sapiens

<400> 7432
Pro Pro Trp His Leu Asp Arg Lys Tyr Gly Ser Cys Ser Thr Ile Leu
 1               5                  10                  15      
Leu Asp Asn Ser Thr Ala Ser Gln Pro Asp Leu Arg His Thr Leu Glu
            20                  25                  30          
Ser Val Ala Leu Ala Ile Tyr Tyr Asn Ile Lys His Ser Phe Leu Glu
        35                  40                  45              
Trp Ile Phe Ile Leu Pro Phe Phe Phe Phe Gln Gln Glu Lys Leu Pro
    50                  55                  60                  
Gly Lys Ser Phe Lys His Asp Pro Lys Arg Asn Cys Ile Phe Arg His
65                  70                  75                  80  
Phe Cys Thr Leu Phe Gln Val Ile Lys Leu Thr Ala Pro Cys Ala Ile
                85                  90                  95      
Val Ala Leu Val Tyr Ile Lys Arg Leu Leu Thr Ser Ala Asn Ile Asp
            100                 105                 110         
Leu Cys Pro Thr Asn Trp Lys Lys Ile Val Leu Gly Thr Met Leu Leu
        115                 120                 125             
Ala Ser Lys Val Trp Arg Asn His Gly Leu Trp Ser Val Asp Asp Ser
    130                 135                 140                 
Gln Asn Ser Lys Asp Thr Ala Val Glu Asn Met Ser Lys Met Glu Lys
145                 150                 155                 160 
Cys Phe Leu Glu Leu Leu Glu Phe Asn Ile His Val Ser Ala Ser Val
                165                 170                 175     
Tyr Ala Lys Tyr Tyr Phe Asp Leu Cys Ala Leu Ala Asn Asp His Asp
            180                 185                 190         
Leu Tyr Phe Leu Phe Ser Phe Leu His Lys Asp Lys Ala Gln Lys Leu
        195                 200                 205             
Glu
    


<210> 7433
<211> 1004
<212> PRT
<213> Homo sapiens

<400> 7433
Met Ala Val Ala Leu Asp Ser Gln Ile Asp Ala Pro Leu Glu Val Glu
 1               5                  10                  15      
Gly Cys Leu Ile Met Lys Val Glu Lys Asp Pro Glu Trp Ala Ser Glu
            20                  25                  30          
Pro Ile Leu Glu Gly Ser Asp Ser Ser Glu Thr Phe Arg Lys Cys Phe
        35                  40                  45              
Arg Gln Phe Cys Tyr Glu Asp Val Thr Gly Pro His Glu Ala Phe Ser
    50                  55                  60                  
Lys Leu Trp Glu Leu Cys Cys Arg Trp Leu Lys Pro Glu Met Arg Ser
65                  70                  75                  80  
Lys Glu Gln Ile Leu Glu Leu Leu Val Ile Glu Gln Phe Leu Thr Ile
                85                  90                  95      
Leu Pro Glu Lys Ile Gln Ala Trp Ala Gln Lys Gln Cys Pro Gln Ser
            100                 105                 110         
Gly Glu Glu Ala Val Ala Leu Val Val His Leu Glu Lys Glu Thr Gly
        115                 120                 125             
Arg Leu Arg Gln Gln His Leu Gln Asp Leu Arg Phe His Leu Ala Ser
    130                 135                 140                 
Asp Leu His Cys Val Glu Ile Tyr Gln Gln Val Ala Val Leu Val Arg
145                 150                 155                 160 
Asp Arg Gln Ile Asp Val Asp Ile Asn Phe Val Ser Ser Pro Val His
                165                 170                 175     
Arg Glu Lys His Ser Pro Leu Gly Ala Ala Trp Glu Val Ala Asp Phe
            180                 185                 190         
Gln Pro Glu Gln Val Glu Thr Gln Pro Arg Ala Val Ser Arg Glu Glu
        195                 200                 205             
Pro Gly Ser Leu His Ser Gly His Gln Glu Gln Leu Asn Arg Lys Arg
    210                 215                 220                 
Glu Arg Arg Pro Leu Pro Lys Asn Ala Arg Pro Ser Pro Trp Val Pro
225                 230                 235                 240 
Ala Leu Ala Asp Glu Trp Asn Thr Leu Asp Gln Glu Val Thr Thr Thr
                245                 250                 255     
Arg Leu Pro Ala Gly Ser Gln Glu Pro Val Lys Asp Val His Val Ala
            260                 265                 270         
Arg Gly Phe Ser Tyr Arg Lys Ser Val His Gln Ile Pro Ala Gln Arg
        275                 280                 285             
Asp Leu Tyr Arg Asp Phe Arg Lys Glu Asn Val Gly Asn Val Val Ser
    290                 295                 300                 
Leu Gly Ser Ala Val Ser Thr Ser Asn Lys Ile Thr Arg Leu Glu Gln
305                 310                 315                 320 
Arg Lys Glu Pro Trp Thr Leu Gly Leu His Ser Ser Asn Lys Arg Ser
                325                 330                 335     
Ile Leu Arg Ser Asn Tyr Val Lys Glu Lys Ser Val His Ala Ile Gln
            340                 345                 350         
Val Pro Ala Arg Ser Ala Gly Lys Thr Trp Arg Glu Gln Gln Gln Trp
        355                 360                 365             
Gly Leu Glu Asp Glu Lys Ile Ala Gly Val His Trp Ser Tyr Glu Glu
    370                 375                 380                 
Thr Lys Thr Phe Leu Ala Ile Leu Lys Glu Ser Arg Phe Tyr Glu Thr
385                 390                 395                 400 
Leu Gln Ala Cys Pro Arg Asn Ser Gln Val Tyr Gly Ala Val Ala Glu
                405                 410                 415     
Trp Leu Arg Glu Cys Gly Phe Leu Arg Thr Pro Glu Gln Cys Arg Thr
            420                 425                 430         
Lys Phe Lys Ser Leu Gln Lys Ser Tyr Arg Lys Val Arg Asn Gly His
        435                 440                 445             
Met Leu Glu Pro Cys Ala Phe Phe Glu Asp Met Asp Ala Leu Leu Asn
    450                 455                 460                 
Pro Ala Ala Arg Ala Pro Ser Thr Asp Lys Pro Lys Glu Met Ile Pro
465                 470                 475                 480 
Val Pro Arg Leu Lys Arg Ile Ala Ile Ser Ala Lys Glu His Ile Ser
                485                 490                 495     
Leu Val Glu Glu Glu Glu Ala Ala Glu Asp Ser Asp Asp Asp Glu Ile
            500                 505                 510         
Gly Ile Glu Phe Ile Arg Lys Ser Glu Ile His Gly Ala Pro Val Leu
        515                 520                 525             
Phe Gln Asn Leu Ser Gly Val His Trp Gly Tyr Glu Glu Thr Lys Thr
    530                 535                 540                 
Phe Leu Asp Ile Leu Arg Glu Thr Arg Phe Tyr Glu Ala Leu Gln Ala
545                 550                 555                 560 
Cys His Arg Lys Ser Lys Leu Tyr Gly Ala Val Ala Glu Gln Leu Arg
                565                 570                 575     
Glu Cys Gly Phe Leu Arg Thr Pro Glu Gln Cys Arg Thr Lys Phe Lys
            580                 585                 590         
Ser Leu Gln Lys Ser Tyr Arg Lys Val Lys Asn Gly His Val Leu Glu
        595                 600                 605             
Ser Cys Ala Phe Tyr Lys Glu Met Asp Ala Leu Ile Asn Ser Arg Ala
    610                 615                 620                 
Ser Ala Pro Ser Pro Ser Thr Pro Glu Glu Val Pro Ser Pro Ser Arg
625                 630                 635                 640 
Gln Glu Arg Gly Gly Ile Glu Val Glu Pro Gln Glu Pro Thr Gly Trp
                645                 650                 655     
Glu Pro Glu Glu Thr Ser Gln Glu Ala Val Ile Glu Asp Ser Cys Ser
            660                 665                 670         
Glu Arg Met Ser Glu Glu Glu Ile Val Gln Glu Pro Glu Phe Gln Gly
        675                 680                 685             
Pro Pro Gly Leu Leu Gln Ser Pro Asn Asp Phe Glu Ile Gly Ser Ser
    690                 695                 700                 
Ile Lys Glu Asp Pro Thr Gln Ile Val Tyr Lys Asp Met Glu Gln His
705                 710                 715                 720 
Arg Ala Leu Ile Glu Lys Ser Lys Arg Val Val Ser Gln Ser Thr Asp
                725                 730                 735     
Pro Ser Lys Tyr Arg Lys Arg Glu Cys Ile Ser Gly Arg Gln Trp Glu
            740                 745                 750         
Asn Leu Gln Gly Ile Arg Gln Gly Lys Pro Met Ser Gln Pro Arg Asp
        755                 760                 765             
Leu Gly Lys Ala Val Val His Gln Arg Pro Phe Val Gly Lys Arg Pro
    770                 775                 780                 
Tyr Arg Leu Leu Lys Tyr Gly Glu Ser Phe Gly Arg Ser Thr Arg Leu
785                 790                 795                 800 
Met Cys Arg Met Thr His His Lys Glu Asn Pro Tyr Lys Cys Gly Val
                805                 810                 815     
Cys Gly Lys Cys Phe Gly Arg Ser Arg Ser Leu Ile Arg His Gln Arg
            820                 825                 830         
Ile His Thr Gly Glu Lys Pro Phe Lys Cys Leu Asp Cys Gly Lys Ser
        835                 840                 845             
Phe Asn Asp Ser Ser Asn Phe Gly Ala His Gln Arg Ile His Thr Gly
    850                 855                 860                 
Glu Lys Pro Tyr Arg Cys Gly Glu Cys Gly Lys Cys Phe Ser Gln Ser
865                 870                 875                 880 
Ser Ser Leu Ile Ile His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr
                885                 890                 895     
Gln Cys Gly Glu Cys Gly Lys Ser Phe Thr Asn Ser Ser His Phe Ser
            900                 905                 910         
Ala His Arg Arg Val His Thr Gly Glu Asn Pro Tyr Lys Cys Val Asp
        915                 920                 925             
Cys Glu Lys Ser Phe Asn Asn Cys Thr Arg Phe Arg Glu His Arg Arg
    930                 935                 940                 
Ile His Thr Gly Glu Lys Pro Tyr Gly Cys Ala Gln Cys Gly Lys Arg
945                 950                 955                 960 
Phe Ser Lys Ser Ser Val Leu Thr Lys His Arg Glu Val His Val Arg
                965                 970                 975     
Glu Lys Pro Leu Pro His Pro Pro Ser Leu Tyr Cys Pro Glu Asn Pro
            980                 985                 990         
His Lys Gly Lys Thr Asp Glu Phe Arg Lys Thr Phe
        995                 1000                


<210> 7434
<211> 915
<212> PRT
<213> Homo sapiens

<400> 7434
Met Ala Glu Thr Leu Ser Gly Leu Gly Asp Ser Gly Ala Ala Gly Pro
 1               5                  10                  15      
Ala Ala Leu Ser Ser Ala Ser Ser Glu Thr Gly Thr Arg Arg Leu Ser
            20                  25                  30          
Asp Leu Arg Val Ile Asp Leu Arg Ala Asp Val Arg Lys Arg Asn Val
        35                  40                  45              
Asp Ser Ser Gly Asn Lys Ser Val Leu Met Glu Arg Leu Lys Lys Ala
    50                  55                  60                  
Ile Glu Asp Glu Gly Gly Asn Pro Asp Glu Ile Glu Ile Thr Ser Glu
65                  70                  75                  80  
Gly Asn Lys Lys Thr Ser Lys Arg Ser Ser Lys Gly Arg Lys Pro Glu
                85                  90                  95      
Glu Glu Gly Val Glu Asp Asn Gly Leu Glu Glu Asn Ser Gly Asp Gly
            100                 105                 110         
Gln Glu Asp Val Glu Thr Ser Leu Glu Asn Leu Gln Asp Ile Asp Ile
        115                 120                 125             
Met Asp Ile Ser Val Leu Asp Glu Ala Glu Ile Asp Asn Gly Ser Val
    130                 135                 140                 
Ala Asp Cys Val Glu Asp Asp Asp Ala Asp Asn Leu Gln Glu Ser Leu
145                 150                 155                 160 
Ser Asp Ser Arg Glu Leu Val Glu Gly Glu Met Lys Glu Leu Pro Glu
                165                 170                 175     
Gln Leu Gln Glu His Ala Ile Glu Asp Lys Glu Thr Ile Asn Asn Leu
            180                 185                 190         
Asp Thr Ser Ser Ser Asp Phe Thr Ile Leu Gln Glu Ile Glu Glu Pro
        195                 200                 205             
Ser Leu Glu Pro Glu Asn Glu Lys Ile Leu Asp Ile Leu Gly Glu Thr
    210                 215                 220                 
Cys Lys Ser Glu Pro Val Lys Glu Glu Ser Ser Glu Leu Glu Gln Pro
225                 230                 235                 240 
Phe Ala Gln Asp Thr Ser Ser Val Gly Pro Asp Arg Lys Leu Ala Glu
                245                 250                 255     
Glu Glu Asp Leu Phe Asp Ser Ala His Pro Glu Glu Gly Asp Leu Asp
            260                 265                 270         
Leu Ala Ser Glu Ser Thr Ala His Ala Gln Ser Ser Lys Ala Asp Ser
        275                 280                 285             
Leu Leu Ala Val Val Lys Arg Glu Pro Ala Glu Gln Pro Gly Asp Gly
    290                 295                 300                 
Glu Arg Thr Asp Cys Glu Pro Val Gly Leu Glu Pro Ala Val Glu Gln
305                 310                 315                 320 
Ser Ser Ala Ala Ser Glu Leu Ala Glu Ala Ser Ser Glu Glu Leu Ala
                325                 330                 335     
Glu Ala Pro Thr Glu Ala Pro Ser Pro Glu Ala Arg Asp Ser Lys Glu
            340                 345                 350         
Asp Gly Arg Lys Phe Asp Phe Asp Ala Cys Asn Glu Val Pro Pro Ala
        355                 360                 365             
Pro Lys Glu Ser Ser Thr Ser Glu Gly Ala Asp Gln Lys Met Ser Ser
    370                 375                 380                 
Pro Glu Asp Asp Ser Asp Thr Lys Arg Leu Ser Lys Glu Glu Lys Gly
385                 390                 395                 400 
Arg Ser Ser Cys Gly Arg Asn Phe Trp Val Ser Gly Leu Ser Ser Thr
                405                 410                 415     
Thr Arg Ala Thr Asp Leu Lys Asn Leu Phe Ser Lys Tyr Gly Lys Val
            420                 425                 430         
Val Gly Ala Lys Val Val Thr Asn Ala Arg Ser Pro Gly Ala Arg Cys
        435                 440                 445             
Tyr Gly Phe Val Thr Met Ser Thr Ala Glu Glu Ala Thr Lys Cys Ile
    450                 455                 460                 
Asn His Leu His Lys Thr Glu Leu His Gly Lys Met Ile Ser Val Glu
465                 470                 475                 480 
Lys Ala Lys Asn Glu Pro Val Gly Lys Lys Thr Ser Asp Lys Arg Asp
                485                 490                 495     
Ser Asp Gly Lys Lys Glu Lys Ser Ser Asn Ser Asp Arg Ser Thr Asn
            500                 505                 510         
Leu Lys Arg Asp Asp Lys Cys Asp Arg Lys Asp Asp Ala Lys Lys Gly
        515                 520                 525             
Asp Asp Gly Ser Gly Glu Lys Ser Lys Asp Gln Asp Asp Gln Lys Pro
    530                 535                 540                 
Gly Pro Ser Glu Arg Ser Arg Ala Thr Lys Ser Gly Ser Arg Gly Thr
545                 550                 555                 560 
Glu Arg Thr Val Val Met Asp Lys Ser Lys Gly Val Pro Val Ile Ser
                565                 570                 575     
Val Lys Thr Ser Gly Ser Lys Glu Arg Ala Ser Lys Ser Gln Asp Arg
            580                 585                 590         
Lys Ser Ala Ser Arg Glu Lys Arg Ser Val Val Ser Phe Asp Lys Val
        595                 600                 605             
Lys Glu Pro Arg Lys Ser Arg Asp Ser Glu Ser His Ser Arg Val Arg
    610                 615                 620                 
Glu Arg Ser Glu Arg Glu Gln Arg Met Gln Ala Gln Trp Glu Arg Glu
625                 630                 635                 640 
Glu Arg Glu Arg Leu Glu Ile Ala Arg Glu Arg Leu Ala Phe Gln Arg
                645                 650                 655     
Gln Arg Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu Arg Glu
            660                 665                 670         
Arg Met His Val Glu His Glu Arg Arg Arg Glu Gln Glu Arg Ile His
        675                 680                 685             
Arg Glu Arg Glu Glu Leu Arg Arg Gln Gln Glu Leu Arg Tyr Glu Gln
    690                 695                 700                 
Glu Arg Arg Pro Ala Val Arg Arg Pro Tyr Asp Leu Asp Arg Arg Asp
705                 710                 715                 720 
Asp Ala Tyr Trp Pro Glu Ala Lys Arg Ala Gly Leu Asp Glu Arg Tyr
                725                 730                 735     
His Ser Asp Phe Asn Arg Gln Glu Arg Phe His Asp Phe Asp His Arg
            740                 745                 750         
Asp Arg Gly Arg Tyr Pro Asp His Ser Val Asp Arg Arg Glu Gly Ser
        755                 760                 765             
Arg Ser Met Met Gly Glu Arg Glu Gly Gln His Tyr Pro Glu Arg His
    770                 775                 780                 
Gly Gly Pro Glu Arg His Gly Arg Asp Ser Arg Asp Gly Trp Gly Gly
785                 790                 795                 800 
Tyr Gly Ser Asp Lys Arg Met Ser Glu Gly Arg Gly Leu Pro Pro Pro
                805                 810                 815     
Pro Arg Arg Asp Trp Gly Asp His Gly Arg Arg Glu Asp Asp Arg Ser
            820                 825                 830         
Trp Gln Gly Thr Ala Asp Gly Gly Met Met Asp Arg Asp His Lys Arg
        835                 840                 845             
Trp Gln Gly Gly Glu Arg Ser Met Ser Gly His Ser Gly Pro Gly His
    850                 855                 860                 
Met Met Asn Arg Gly Gly Met Ser Gly Arg Gly Ser Phe Ala Pro Gly
865                 870                 875                 880 
Gly Ala Ser Arg Gly His Pro Ile Pro His Gly Gly Met Gln Gly Gly
                885                 890                 895     
Phe Gly Gly Gln Ser Arg Gly Ser Arg Pro Ser Asp Ala Arg Phe Thr
            900                 905                 910         
Arg Arg Tyr
        915 


<210> 7435
<211> 1249
<212> PRT
<213> Homo sapiens

<400> 7435
Met Ala Thr Ala Ala Thr Glu Glu Pro Phe Pro Phe His Gly Leu Leu
 1               5                  10                  15      
Pro Lys Lys Glu Thr Gly Ala Ala Ser Phe Leu Cys Arg Tyr Pro Glu
            20                  25                  30          
Tyr Asp Gly Arg Gly Val Leu Ile Ala Val Leu Asp Thr Gly Val Asp
        35                  40                  45              
Pro Gly Ala Pro Gly Met Gln Val Thr Thr Asp Gly Lys Pro Lys Ile
    50                  55                  60                  
Val Asp Ile Ile Asp Thr Thr Gly Ser Gly Asp Val Asn Thr Ala Thr
65                  70                  75                  80  
Glu Val Glu Pro Lys Asp Gly Glu Ile Val Gly Leu Ser Gly Arg Val
                85                  90                  95      
Leu Lys Ile Pro Ala Ser Trp Thr Asn Pro Ser Gly Lys Tyr His Ile
            100                 105                 110         
Gly Ile Lys Asn Gly Tyr Asp Phe Tyr Pro Lys Ala Leu Lys Glu Arg
        115                 120                 125             
Ile Gln Lys Glu Arg Lys Glu Lys Ile Trp Asp Pro Val His Arg Val
    130                 135                 140                 
Ala Leu Ala Glu Ala Cys Arg Lys Gln Glu Glu Phe Asp Val Ala Asn
145                 150                 155                 160 
Asn Gly Ser Ser Gln Ala Asn Lys Leu Ile Lys Glu Glu Leu Gln Ser
                165                 170                 175     
Gln Val Glu Leu Leu Asn Ser Phe Glu Lys Lys Tyr Ser Asp Pro Gly
            180                 185                 190         
Pro Val Tyr Asp Cys Leu Val Trp His Asp Gly Glu Val Trp Arg Ala
        195                 200                 205             
Cys Ile Asp Ser Asn Glu Asp Gly Asp Leu Ser Lys Ser Thr Val Leu
    210                 215                 220                 
Arg Asn Tyr Lys Glu Ala Gln Glu Tyr Gly Ser Phe Gly Thr Ala Glu
225                 230                 235                 240 
Met Leu Asn Tyr Ser Val Asn Ile Tyr Asp Asp Gly Asn Leu Leu Ser
                245                 250                 255     
Ile Val Thr Ser Gly Gly Ala His Gly Thr His Val Ala Ser Ile Ala
            260                 265                 270         
Ala Gly His Phe Pro Glu Glu Pro Glu Arg Asn Gly Val Ala Pro Gly
        275                 280                 285             
Ala Gln Ile Leu Ser Ile Lys Ile Gly Asp Thr Arg Leu Ser Thr Met
    290                 295                 300                 
Glu Thr Gly Thr Gly Leu Ile Arg Ala Met Ile Glu Val Ile Asn His
305                 310                 315                 320 
Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro
                325                 330                 335     
Asn Ser Gly Arg Ile Cys Glu Val Ile Asn Glu Ala Val Trp Lys His
            340                 345                 350         
Asn Ile Ile Tyr Val Ser Ser Ala Gly Asn Asn Gly Pro Cys Leu Ser
        355                 360                 365             
Thr Val Gly Cys Pro Gly Gly Thr Thr Ser Ser Val Ile Gly Val Gly
    370                 375                 380                 
Ala Tyr Val Ser Pro Asp Met Met Val Ala Glu Tyr Ser Leu Arg Glu
385                 390                 395                 400 
Lys Leu Pro Ala Asn Gln Tyr Thr Trp Ser Ser Arg Gly Pro Ser Ala
                405                 410                 415     
Asp Gly Ala Leu Gly Val Ser Ile Ser Ala Pro Gly Gly Ala Ile Ala
            420                 425                 430         
Ser Val Pro Asn Trp Thr Leu Arg Gly Thr Gln Leu Met Asn Gly Thr
        435                 440                 445             
Ser Met Ser Ser Pro Asn Ala Cys Gly Gly Ile Ala Leu Ile Leu Ser
    450                 455                 460                 
Gly Leu Lys Ala Asn Asn Ile Asp Tyr Thr Val His Ser Val Arg Arg
465                 470                 475                 480 
Ala Leu Glu Asn Thr Ala Val Lys Ala Asp Asn Ile Glu Val Phe Ala
                485                 490                 495     
Gln Gly His Gly Ile Ile Gln Val Asp Lys Ala Tyr Asp Tyr Leu Val
            500                 505                 510         
Gln Asn Thr Ser Phe Ala Asn Lys Leu Gly Phe Thr Val Thr Val Gly
        515                 520                 525             
Asn Asn Arg Gly Ile Tyr Leu Arg Asp Pro Val Gln Val Ala Ala Pro
    530                 535                 540                 
Ser Asp His Gly Val Gly Ile Glu Pro Val Phe Pro Glu Asn Thr Glu
545                 550                 555                 560 
Asn Ser Glu Lys Ile Ser Leu Gln Leu His Leu Ala Leu Thr Ser Asn
                565                 570                 575     
Ser Ser Trp Val Gln Cys Pro Ser His Leu Glu Leu Met Asn Gln Cys
            580                 585                 590         
Arg His Ile Asn Ile Arg Val Asp Pro Arg Gly Leu Arg Glu Gly Leu
        595                 600                 605             
His Tyr Thr Glu Val Cys Gly Tyr Asp Ile Ala Ser Pro Asn Ala Gly
    610                 615                 620                 
Pro Leu Phe Arg Val Pro Ile Thr Ala Val Ile Ala Ala Lys Val Asn
625                 630                 635                 640 
Glu Ser Ser His Tyr Asp Leu Ala Phe Thr Asp Val His Phe Lys Pro
                645                 650                 655     
Gly Gln Ile Arg Arg His Phe Ile Glu Val Pro Glu Gly Ala Thr Trp
            660                 665                 670         
Ala Glu Val Thr Val Cys Ser Cys Ser Ser Glu Val Ser Ala Lys Phe
        675                 680                 685             
Val Leu His Ala Val Gln Leu Val Lys Gln Arg Ala Tyr Arg Ser His
    690                 695                 700                 
Glu Phe Tyr Lys Phe Cys Ser Leu Pro Glu Lys Gly Thr Leu Thr Glu
705                 710                 715                 720 
Ala Phe Pro Val Leu Gly Gly Lys Ala Ile Glu Phe Cys Ile Ala Arg
                725                 730                 735     
Trp Trp Ala Ser Leu Ser Asp Val Asn Ile Asp Tyr Thr Ile Ser Phe
            740                 745                 750         
His Gly Ile Val Cys Thr Ala Pro Gln Leu Asn Ile His Ala Ser Glu
        755                 760                 765             
Gly Ile Asn Arg Phe Asp Val Gln Ser Ser Leu Lys Tyr Glu Asp Leu
    770                 775                 780                 
Ala Pro Cys Ile Thr Leu Lys Asn Trp Val Gln Thr Leu Arg Pro Val
785                 790                 795                 800 
Ser Ala Lys Thr Lys Pro Leu Gly Ser Arg Asp Val Leu Pro Asn Asn
                805                 810                 815     
Arg Gln Leu Tyr Glu Met Val Leu Thr Tyr Asn Phe His Gln Pro Lys
            820                 825                 830         
Ser Gly Glu Val Thr Pro Ser Cys Pro Leu Leu Cys Glu Leu Leu Tyr
        835                 840                 845             
Glu Ser Glu Phe Asp Ser Gln Leu Trp Ile Ile Phe Asp Gln Asn Lys
    850                 855                 860                 
Arg Gln Met Gly Ser Gly Asp Ala Tyr Pro His Gln Tyr Ser Leu Lys
865                 870                 875                 880 
Leu Glu Lys Gly Asp Tyr Thr Ile Arg Leu Gln Ile Arg His Glu Gln
                885                 890                 895     
Ile Ser Asp Leu Glu Arg Leu Lys Asp Leu Pro Phe Ile Val Ser His
            900                 905                 910         
Arg Leu Ser Asn Thr Leu Ser Leu Asp Ile His Glu Asn His Ser Phe
        915                 920                 925             
Ala Leu Leu Gly Lys Lys Lys Ser Ser Asn Leu Thr Leu Pro Pro Lys
    930                 935                 940                 
Tyr Asn Gln Pro Phe Phe Val Thr Ser Leu Pro Asp Asp Lys Ile Pro
945                 950                 955                 960 
Lys Gly Ala Gly Pro Gly Cys Tyr Leu Ala Gly Ser Leu Thr Leu Ser
                965                 970                 975     
Lys Thr Glu Leu Gly Lys Lys Ala Asp Val Ile Pro Val His Tyr Tyr
            980                 985                 990         
Leu Ile Pro Pro Pro Thr Lys Thr Lys Asn Gly Ser Lys Asp Lys Glu
        995                 1000                1005            
Lys Asp Ser Glu Lys Glu Lys Asp Leu Lys Glu Glu Phe Thr Glu Ala
    1010                1015                1020                
Leu Arg Asp Leu Lys Ile Gln Trp Met Thr Lys Leu Asp Ser Ser Asp
1025                1030                1035                1040
Ile Tyr Asn Glu Leu Lys Glu Thr Tyr Pro Asn Tyr Leu Pro Leu Tyr
                1045                1050                1055    
Val Ala Arg Leu His Gln Leu Asp Ala Glu Lys Glu Arg Met Lys Arg
            1060                1065                1070        
Leu Asn Glu Ile Val Asp Ala Ala Asn Ala Val Ile Ser His Ile Asp
        1075                1080                1085            
Gln Thr Ala Leu Ala Val Tyr Ile Ala Met Lys Thr Asp Pro Arg Pro
    1090                1095                1100                
Asp Ala Ala Thr Ile Lys Asn Asp Met Asp Lys Gln Lys Ser Thr Leu
1105                1110                1115                1120
Val Asp Ala Leu Cys Arg Lys Gly Cys Ala Leu Ala Asp His Leu Leu
                1125                1130                1135    
His Thr Gln Ala Gln Asp Gly Ala Ile Ser Thr Asp Ala Glu Gly Lys
            1140                1145                1150        
Glu Glu Glu Gly Glu Ser Pro Leu Asp Ser Leu Ala Glu Thr Phe Trp
        1155                1160                1165            
Glu Thr Thr Lys Trp Thr Asp Leu Phe Asp Asn Lys Val Leu Thr Phe
    1170                1175                1180                
Ala Tyr Lys His Ala Leu Val Asn Lys Met Tyr Gly Arg Gly Leu Lys
1185                1190                1195                1200
Phe Ala Thr Lys Leu Val Glu Glu Lys Pro Thr Lys Glu Asn Trp Lys
                1205                1210                1215    
Asn Cys Ile Gln Leu Met Lys Leu Leu Gly Trp Thr His Cys Ala Ser
            1220                1225                1230        
Phe Thr Glu Asn Trp Leu Pro Ile Met Tyr Pro Pro Asp Tyr Cys Val
        1235                1240                1245            
Phe
    


<210> 7436
<211> 898
<212> PRT
<213> Homo sapiens

<400> 7436
Met Arg Lys Gly Val Leu Lys Asp Pro Glu Ile Ala Asp Leu Phe Tyr
 1               5                  10                  15      
Lys Asp Asp Pro Glu Glu Leu Phe Ile Gly Leu His Glu Ile Gly His
            20                  25                  30          
Gly Ser Phe Gly Ala Val Tyr Phe Ala Thr Asn Ala His Thr Ser Glu
        35                  40                  45              
Val Val Ala Ile Lys Lys Met Ser Tyr Ser Gly Lys Gln Thr His Glu
    50                  55                  60                  
Lys Trp Gln Asp Ile Leu Lys Glu Val Lys Phe Leu Arg Gln Leu Lys
65                  70                  75                  80  
His Pro Asn Thr Ile Glu Tyr Lys Gly Cys Tyr Leu Lys Glu His Thr
                85                  90                  95      
Ala Trp Leu Val Met Glu Tyr Cys Leu Gly Ser Ala Ser Asp Leu Leu
            100                 105                 110         
Glu Val His Lys Lys Pro Leu Gln Glu Val Glu Ile Ala Ala Ile Thr
        115                 120                 125             
His Gly Ala Leu His Gly Leu Ala Tyr Leu His Ser His Ala Leu Ile
    130                 135                 140                 
His Arg Asp Ile Lys Ala Gly Asn Ile Leu Leu Thr Glu Pro Gly Gln
145                 150                 155                 160 
Val Lys Leu Ala Asp Phe Gly Ser Ala Ser Met Ala Ser Pro Ala Asn
                165                 170                 175     
Ser Phe Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Ile Leu Ala
            180                 185                 190         
Met Asp Glu Gly Gln Tyr Asp Gly Lys Val Asp Ile Trp Ser Leu Gly
        195                 200                 205             
Ile Thr Cys Ile Glu Leu Ala Glu Arg Lys Pro Pro Leu Phe Asn Met
    210                 215                 220                 
Asn Ala Met Ser Ala Leu Tyr His Ile Ala Gln Asn Asp Ser Pro Thr
225                 230                 235                 240 
Leu Gln Ser Asn Glu Trp Thr Asp Ser Phe Arg Arg Phe Val Asp Tyr
                245                 250                 255     
Cys Leu Gln Lys Ile Pro Gln Glu Arg Pro Thr Ser Ala Glu Leu Leu
            260                 265                 270         
Arg His Asp Phe Val Arg Arg Asp Arg Pro Leu Arg Val Leu Ile Asp
        275                 280                 285             
Leu Ile Gln Arg Thr Lys Asp Ala Val Arg Glu Leu Asp Asn Leu Gln
    290                 295                 300                 
Tyr Arg Lys Met Lys Lys Ile Leu Phe Gln Glu Thr Arg Asn Gly Pro
305                 310                 315                 320 
Leu Asn Glu Ser Gln Glu Asp Glu Glu Asp Ser Glu His Gly Thr Ser
                325                 330                 335     
Leu Asn Arg Glu Met Asp Ser Leu Gly Ser Asn His Ser Ile Pro Ser
            340                 345                 350         
Met Ser Val Ser Thr Gly Ser Gln Ser Ser Ser Val Asn Ser Met Gln
        355                 360                 365             
Glu Val Met Asp Glu Ser Ser Ser Glu Leu Val Met Met His Asp Asp
    370                 375                 380                 
Glu Ser Thr Ile Asn Ser Ser Ser Ser Val Val His Lys Lys Asp His
385                 390                 395                 400 
Val Phe Ile Arg Asp Glu Ala Gly His Gly Asp Pro Arg Pro Glu Pro
                405                 410                 415     
Arg Pro Thr Gln Ser Val Gln Ser Gln Ala Leu His Tyr Arg Asn Arg
            420                 425                 430         
Glu Arg Phe Ala Thr Ile Lys Ser Ala Ser Leu Val Thr Arg Gln Ile
        435                 440                 445             
His Glu His Glu Gln Glu Asn Glu Leu Arg Glu Gln Met Ser Gly Tyr
    450                 455                 460                 
Lys Arg Met Arg Arg Gln His Gln Lys Gln Leu Ile Ala Leu Glu Asn
465                 470                 475                 480 
Lys Leu Lys Ala Glu Met Asp Glu His Arg Leu Lys Leu Gln Lys Glu
                485                 490                 495     
Val Glu Thr His Ala Asn Asn Ser Ser Ile Glu Leu Glu Lys Leu Ala
            500                 505                 510         
Lys Lys Gln Val Ala Ile Ile Glu Lys Glu Ala Lys Val Ala Ala Ala
        515                 520                 525             
Asp Glu Lys Lys Phe Gln Gln Gln Ile Leu Ala Gln Gln Lys Lys Asp
    530                 535                 540                 
Leu Thr Thr Phe Leu Glu Ser Gln Lys Lys Gln Tyr Lys Ile Cys Lys
545                 550                 555                 560 
Glu Lys Ile Lys Glu Glu Met Asn Glu Asp His Ser Thr Pro Lys Lys
                565                 570                 575     
Glu Lys Gln Glu Arg Ile Ser Lys His Lys Glu Asn Leu Gln His Thr
            580                 585                 590         
Gln Ala Glu Glu Glu Ala His Leu Leu Thr Gln Gln Arg Leu Tyr Tyr
        595                 600                 605             
Asp Lys Asn Cys Arg Phe Phe Lys Arg Lys Ile Met Ile Lys Arg His
    610                 615                 620                 
Glu Val Glu Gln Gln Asn Ile Arg Glu Glu Leu Asn Lys Lys Arg Thr
625                 630                 635                 640 
Gln Lys Glu Met Glu His Ala Met Leu Ile Arg His Asp Glu Ser Thr
                645                 650                 655     
Arg Glu Leu Glu Tyr Arg Gln Leu His Thr Leu Gln Lys Leu Arg Met
            660                 665                 670         
Asp Leu Ile Arg Leu Gln His Gln Thr Glu Leu Glu Asn Gln Leu Glu
        675                 680                 685             
Tyr Asn Lys Arg Arg Glu Arg Glu Leu His Arg Lys His Val Met Glu
    690                 695                 700                 
Leu Arg Gln Gln Pro Lys Asn Leu Lys Ala Met Glu Met Gln Ile Lys
705                 710                 715                 720 
Lys Gln Phe Gln Asp Thr Cys Lys Val Gln Thr Lys Gln Tyr Lys Ala
                725                 730                 735     
Leu Lys Asn His Gln Leu Glu Val Thr Pro Lys Asn Glu His Lys Thr
            740                 745                 750         
Ile Leu Lys Thr Leu Lys Asp Glu Gln Thr Arg Lys Leu Ala Ile Leu
        755                 760                 765             
Ala Glu Gln Tyr Glu Gln Ser Ile Asn Glu Met Met Ala Ser Gln Ala
    770                 775                 780                 
Leu Arg Leu Asp Glu Ala Gln Glu Ala Glu Cys Gln Ala Leu Arg Leu
785                 790                 795                 800 
Gln Leu Gln Gln Glu Met Glu Leu Leu Asn Ala Tyr Gln Ser Lys Ile
                805                 810                 815     
Lys Met Gln Thr Glu Ala Gln His Glu Arg Glu Leu Gln Lys Leu Glu
            820                 825                 830         
Gln Arg Val Ser Leu Arg Arg Ala His Leu Glu Gln Lys Ile Glu Glu
        835                 840                 845             
Glu Leu Ala Ala Leu Gln Lys Glu Arg Ser Glu Arg Ile Lys Asn Leu
    850                 855                 860                 
Leu Glu Arg Gln Glu Arg Glu Ile Glu Thr Phe Asp Met Glu Ser Leu
865                 870                 875                 880 
Arg Met Gly Phe Gly Asn Leu Val Thr Leu Asp Phe Pro Lys Glu Asp
                885                 890                 895     
Tyr Arg
        


<210> 7437
<211> 1411
<212> PRT
<213> Homo sapiens

<400> 7437
Met Ser Leu Ser Ser Gly Ala Ser Gly Gly Lys Gly Val Asp Ala Asn
 1               5                  10                  15      
Pro Val Glu Thr Tyr Asp Ser Gly Asp Glu Trp Asp Ile Gly Val Gly
            20                  25                  30          
Asn Leu Ile Ile Asp Leu Asp Ala Asp Leu Glu Lys Asp Gln Gln Lys
        35                  40                  45              
Leu Glu Met Ser Gly Ser Lys Glu Val Gly Ile Pro Ala Pro Asn Ala
    50                  55                  60                  
Val Ala Thr Leu Pro Asp Asn Ile Lys Phe Val Thr Pro Val Pro Gly
65                  70                  75                  80  
Pro Gln Gly Lys Glu Gly Lys Ser Lys Ser Lys Arg Ser Lys Ser Gly
                85                  90                  95      
Lys Asp Thr Ser Lys Pro Thr Pro Gly Thr Ser Leu Phe Thr Pro Ser
            100                 105                 110         
Glu Gly Ala Ala Ser Lys Lys Glu Val Gln Gly Arg Ser Gly Asp Gly
        115                 120                 125             
Ala Asn Ala Gly Gly Leu Val Ala Ala Ile Ala Pro Lys Gly Ser Glu
    130                 135                 140                 
Lys Ala Ala Lys Ala Ser Arg Ser Val Ala Gly Ser Lys Lys Glu Lys
145                 150                 155                 160 
Glu Asn Ser Ser Ser Lys Ser Lys Lys Glu Arg Ser Glu Gly Val Gly
                165                 170                 175     
Thr Cys Ser Glu Lys Asp Pro Gly Val Leu Gln Pro Val Pro Leu Gly
            180                 185                 190         
Gly Arg Gly Gly Gln Tyr Asp Gly Ser Ala Gly Val Asp Thr Gly Ala
        195                 200                 205             
Val Glu Pro Leu Gly Ser Ile Ala Ile Glu Pro Gly Ala Ala Leu Asn
    210                 215                 220                 
Pro Leu Gly Thr Lys Pro Glu Pro Glu Glu Gly Glu Asn Glu Cys Arg
225                 230                 235                 240 
Leu Leu Lys Lys Val Lys Ser Glu Lys Met Glu Ser Pro Val Ser Thr
                245                 250                 255     
Pro Ala Val Leu Pro Ile His Leu Leu Val Pro Val Val Asn Asn Asp
            260                 265                 270         
Ile Ser Ser Pro Cys Glu Gln Ile Met Val Arg Thr Arg Ser Val Gly
        275                 280                 285             
Val Asn Thr Cys Asp Val Ala Leu Ala Thr Glu Pro Glu Cys Leu Gly
    290                 295                 300                 
Pro Cys Glu Pro Gly Thr Ser Val Asn Leu Glu Gly Ile Val Trp Gln
305                 310                 315                 320 
Glu Thr Glu Asp Gly Met Leu Val Val Asn Val Thr Trp Arg Asn Lys
                325                 330                 335     
Thr Tyr Val Gly Thr Leu Leu Asp Cys Thr Arg His Asp Trp Ala Pro
            340                 345                 350         
Pro Arg Phe Cys Asp Ser Pro Thr Ser Asp Leu Glu Met Arg Asn Gly
        355                 360                 365             
Arg Gly Arg Gly Lys Arg Met Arg Pro Asn Ser Asn Thr Pro Val Asn
    370                 375                 380                 
Glu Thr Ala Thr Ala Ser Asp Ser Lys Gly Thr Ser Asn Ser Ser Lys
385                 390                 395                 400 
Thr Arg Ala Gly Ala Asn Ser Lys Gly Arg Arg Gly Ser Gln Asn Ser
                405                 410                 415     
Ser Glu His Arg Pro Pro Ala Ser Ser Thr Ser Glu Asp Val Lys Ala
            420                 425                 430         
Ser Pro Ser Ser Ala Asn Lys Arg Lys Asn Lys Pro Leu Ser Asp Met
        435                 440                 445             
Glu Leu Asn Ser Ser Ser Glu Asp Ser Lys Gly Ser Lys Arg Val Arg
    450                 455                 460                 
Thr Asn Ser Met Gly Ser Ala Thr Gly Pro Leu Pro Gly Thr Lys Val
465                 470                 475                 480 
Glu Pro Thr Val Leu Asp Arg Asn Cys Pro Ser Pro Val Leu Ile Asp
                485                 490                 495     
Cys Pro His Pro Asn Cys Asn Lys Lys Tyr Lys His Ile Asn Gly Leu
            500                 505                 510         
Lys Tyr His Gln Ala His Ala His Thr Asp Asp Asp Ser Lys Pro Glu
        515                 520                 525             
Ala Asp Gly Asp Ser Glu Tyr Gly Glu Glu Pro Ile Leu His Ala Asp
    530                 535                 540                 
Leu Gly Ser Cys Asn Gly Ala Ser Val Ser Gln Lys Gly Ser Leu Ser
545                 550                 555                 560 
Pro Ala Arg Ser Ala Thr Pro Lys Val Arg Leu Val Glu Pro His Ser
                565                 570                 575     
Pro Ser Pro Ser Ser Lys Phe Ser Thr Lys Gly Leu Cys Lys Lys Lys
            580                 585                 590         
Leu Ser Gly Glu Gly Asp Thr Asp Leu Gly Ala Leu Ser Asn Asp Gly
        595                 600                 605             
Ser Asp Asp Gly Pro Ser Val Met Asp Glu Thr Ser Asn Asp Ala Phe
    610                 615                 620                 
Asp Ser Leu Glu Arg Lys Cys Met Glu Lys Glu Lys Cys Lys Lys Pro
625                 630                 635                 640 
Ser Ser Leu Lys Pro Glu Lys Ile Pro Ser Lys Ser Leu Lys Ser Ala
                645                 650                 655     
Arg Pro Ile Ala Pro Ala Ile Pro Pro Gln Gln Ile Tyr Thr Phe Gln
            660                 665                 670         
Thr Ala Thr Phe Thr Ala Ala Ser Pro Gly Ser Ser Ser Gly Leu Thr
        675                 680                 685             
Ala Thr Val Ala Gln Ala Met Pro Asn Ser Pro Gln Leu Lys Pro Ile
    690                 695                 700                 
Gln Pro Lys Pro Thr Val Met Gly Glu Pro Phe Thr Val Asn Pro Ala
705                 710                 715                 720 
Leu Thr Pro Ala Lys Asp Lys Lys Lys Lys Asp Lys Lys Lys Lys Glu
                725                 730                 735     
Ser Ser Lys Glu Leu Glu Ser Pro Leu Thr Pro Gly Lys Val Cys Arg
            740                 745                 750         
Ala Glu Glu Gly Lys Ser Pro Phe Arg Glu Ser Ser Gly Asp Gly Met
        755                 760                 765             
Lys Met Glu Gly Leu Leu Asn Gly Ser Ser Asp Pro His Gln Ser Arg
    770                 775                 780                 
Leu Ala Ser Ile Lys Ala Glu Ala Asp Lys Ile Tyr Ser Phe Thr Asp
785                 790                 795                 800 
Asn Ala Pro Ser Pro Ser Ile Gly Gly Ser Ser Arg Leu Glu Asn Thr
                805                 810                 815     
Thr Pro Thr Gln Pro Leu Thr Pro Leu His Val Val Thr Gln Asn Gly
            820                 825                 830         
Ala Glu Ala Ser Ser Val Lys Thr Asn Ser Pro Ala Tyr Ser Asp Ile
        835                 840                 845             
Ser Asp Ala Gly Glu Asp Gly Glu Gly Lys Val Asp Ser Val Lys Ser
    850                 855                 860                 
Lys Asp Ala Glu Gln Leu Val Lys Glu Gly Ala Lys Lys Thr Leu Phe
865                 870                 875                 880 
Pro Pro Gln Pro Gln Ser Lys Asp Ser Pro Tyr Tyr Gln Gly Phe Glu
                885                 890                 895     
Ser Tyr Tyr Ser Pro Ser Tyr Ala Gln Ser Ser Pro Gly Ala Leu Asn
            900                 905                 910         
Pro Ser Ser Gln Ala Gly Val Glu Ser Gln Ala Leu Lys Thr Lys Arg
        915                 920                 925             
Asp Glu Glu Pro Glu Ser Ile Glu Gly Lys Val Lys Asn Asp Ile Cys
    930                 935                 940                 
Glu Glu Lys Lys Pro Glu Leu Ser Ser Ser Ser Gln Gln Pro Ser Val
945                 950                 955                 960 
Ile Gln Gln Arg Pro Asn Met Tyr Met Gln Ser Leu Tyr Tyr Asn Gln
                965                 970                 975     
Tyr Ala Tyr Val Pro Pro Tyr Gly Tyr Ser Asp Gln Ser Tyr His Thr
            980                 985                 990         
His Leu Leu Ser Thr Asn Thr Ala Tyr Arg Gln Gln Tyr Glu Glu Gln
        995                 1000                1005            
Gln Lys Arg Gln Ser Leu Glu Gln Gln Gln Arg Gly Val Asp Lys Lys
    1010                1015                1020                
Ala Glu Met Gly Leu Lys Glu Arg Glu Ala Ala Leu Lys Glu Glu Trp
1025                1030                1035                1040
Lys Gln Lys Pro Ser Ile Pro Pro Thr Leu Thr Lys Ala Pro Ser Leu
                1045                1050                1055    
Thr Asp Leu Val Lys Ser Gly Pro Gly Lys Ala Lys Glu Pro Gly Ala
            1060                1065                1070        
Asp Pro Ala Lys Ser Val Ile Ile Pro Lys Leu Asp Asp Ser Ser Lys
        1075                1080                1085            
Leu Pro Gly Gln Ala Pro Glu Gly Leu Lys Val Lys Leu Ser Asp Ala
    1090                1095                1100                
Ser His Leu Ser Lys Glu Ala Ser Glu Ala Lys Thr Gly Ala Glu Cys
1105                1110                1115                1120
Gly Arg Gln Ala Glu Met Asp Pro Ile Leu Trp Tyr Arg Gln Glu Ala
                1125                1130                1135    
Glu Pro Arg Met Trp Thr Tyr Val Tyr Pro Ala Lys Tyr Ser Asp Ile
            1140                1145                1150        
Lys Ser Glu Asp Glu Arg Trp Lys Glu Glu Arg Asp Arg Lys Leu Lys
        1155                1160                1165            
Glu Glu Arg Ser Arg Ser Lys Asp Ser Val Pro Lys Glu Asp Gly Lys
    1170                1175                1180                
Glu Ser Thr Ser Ser Asp Cys Lys Leu Pro Thr Ser Glu Glu Ser Arg
1185                1190                1195                1200
Leu Gly Ser Lys Glu Pro Arg Pro Ser Val His Val Pro Val Ser Ser
                1205                1210                1215    
Pro Leu Thr Gln His Gln Ser Tyr Ile Pro Tyr Met His Gly Tyr Ser
            1220                1225                1230        
Tyr Ser Gln Ser Tyr Asp Pro Asn His Pro Ser Tyr Arg Ser Met Pro
        1235                1240                1245            
Ala Val Met Met Gln Asn Tyr Pro Gly Ser Tyr Leu Pro Ser Ser Tyr
    1250                1255                1260                
Ser Phe Ser Pro Tyr Gly Ser Lys Val Ser Gly Gly Glu Asp Ala Asp
1265                1270                1275                1280
Lys Ala Arg Ala Ser Pro Ser Val Thr Cys Lys Ser Ser Ser Glu Ser
                1285                1290                1295    
Lys Ala Leu Asp Ile Leu Gln Gln His Ala Ser His Tyr Lys Ser Lys
            1300                1305                1310        
Ser Pro Thr Ile Ser Asp Lys Thr Ser Gln Glu Arg Asp Arg Gly Gly
        1315                1320                1325            
Cys Gly Val Val Gly Gly Gly Gly Ser Cys Ser Ser Val Gly Gly Ala
    1330                1335                1340                
Ser Gly Gly Glu Arg Ser Val Asp Arg Pro Arg Thr Ser Pro Ser Gln
1345                1350                1355                1360
Arg Leu Met Ser Thr His His His His His His Leu Gly Tyr Ser Leu
                1365                1370                1375    
Leu Pro Ala Gln Tyr Asn Leu Pro Tyr Ala Ala Gly Leu Ser Ser Thr
            1380                1385                1390        
Ala Ile Val Ala Ser Gln Gln Gly Ser Thr Pro Ser Leu Tyr Pro Pro
        1395                1400                1405            
Pro Arg Arg
    1410    


<210> 7438
<211> 1149
<212> PRT
<213> Homo sapiens

<400> 7438
Met Ile Thr Gln Ile Gly Ile Leu Asn Pro Leu Val Trp Val Gly Phe
 1               5                  10                  15      
Lys Thr Val Val Ile Pro Met Lys Gly Lys Ile Ala Gln Ile Ala Ile
            20                  25                  30          
Glu Lys Ala Leu Ser Asp Ala Phe Gln Lys Leu Leu Ile Val Val Leu
        35                  40                  45              
Glu Met Pro Ala Pro Pro Gln Glu Ser Thr Glu Asn Leu Val Pro Phe
    50                  55                  60                  
Leu Asp Thr Trp Asp Ser Ala Gly Glu Gln Pro Leu Glu Pro Glu Gln
65                  70                  75                  80  
Phe Leu Ala Ser Gln Gln Asp Leu Lys Asp Lys Leu Ser Pro Gln Glu
                85                  90                  95      
Arg Leu Pro Val Ser Pro Lys Lys Leu Lys Lys Asp Pro Ala Gln Arg
            100                 105                 110         
Trp Ser Leu Ala Glu Ile Ile Gly Ile Ala Arg Gln Leu Ser Thr Pro
        115                 120                 125             
Gln Ser Gln Lys Gln Thr Leu Gln Asn Glu Tyr Ser Ser Thr Asp Thr
    130                 135                 140                 
Pro Tyr Pro Ser Ser Leu Pro Pro Glu Leu Arg Val Lys Ser Asp Glu
145                 150                 155                 160 
Pro Pro Gly Pro Ser Glu Gln Val Gly Pro Ser Gln Phe His Leu Glu
                165                 170                 175     
Pro Glu Thr Gln Asn Pro Glu Thr Leu Glu Asp Ile Gln Ser Ser Ser
            180                 185                 190         
Leu Gln Gln Glu Ala Pro Ala Gln Leu Pro Gln Leu Leu Glu Glu Glu
        195                 200                 205             
Pro Ser Ser Met Gln Gln Glu Ala Pro Ala Leu Pro Pro Glu Ser Ser
    210                 215                 220                 
Met Glu Ser Leu Thr Leu Pro Asn His Glu Val Ser Val Gln Pro Pro
225                 230                 235                 240 
Gly Glu Asp Gln Ala Tyr Tyr His Leu Pro Asn Ile Thr Val Lys Pro
                245                 250                 255     
Ala Asp Val Glu Val Thr Ile Thr Ser Glu Pro Thr Asn Glu Thr Glu
            260                 265                 270         
Ser Ser Gln Ala Gln Gln Glu Thr Pro Ile Gln Phe Pro Glu Glu Val
        275                 280                 285             
Glu Pro Ser Ala Thr Gln Gln Glu Ala Pro Ile Glu Pro Pro Val Ser
    290                 295                 300                 
Pro Met Glu His Glu Leu Ser Ile Ser Glu Gln Gln Gln Pro Val Gln
305                 310                 315                 320 
Pro Ser Glu Ser Ser Arg Glu Val Glu Ser Ser Leu Thr Gln Gln Glu
                325                 330                 335     
Thr Pro Gly Gln Pro Pro Glu His His Glu Val Thr Val Ser Pro Pro
            340                 345                 350         
Gly His His Gln Thr His His Leu Asp Ser Pro Ser Val Ser Val Lys
        355                 360                 365             
Pro Pro Asp Val Gln Leu Thr Ile Ala Ala Glu Pro Ser Ala Glu Val
    370                 375                 380                 
Gly Thr Ser Leu Val His Gln Glu Ala Thr Ala Arg Leu Ser Gly Ser
385                 390                 395                 400 
Gly Asn Asp Val Glu Pro Pro Ala Ile Gln His Gly Gly Pro Pro Leu
                405                 410                 415     
Leu Pro Glu Ser Ser Glu Glu Ala Gly Pro Leu Ala Val Gln Gln Glu
            420                 425                 430         
Thr Ser Phe Gln Ser Pro Glu Pro Ile Asn Asn Glu Asn Pro Ser Pro
        435                 440                 445             
Thr Gln Gln Glu Ala Ala Ala Glu His Pro Gln Thr Ala Glu Glu Gly
    450                 455                 460                 
Glu Ser Ser Leu Thr His Gln Glu Ala Pro Ala Gln Thr Pro Glu Phe
465                 470                 475                 480 
Pro Asn Val Val Val Ala Gln Pro Pro Glu His Ser His Leu Thr Gln
                485                 490                 495     
Ala Thr Val Gln Pro Leu Asp Leu Gly Phe Thr Ile Thr Pro Glu Ser
            500                 505                 510         
Met Thr Glu Val Glu Leu Ser Pro Thr Met Lys Glu Thr Pro Thr Gln
        515                 520                 525             
Pro Pro Lys Lys Val Val Pro Gln Leu Arg Val Tyr Gln Gly Val Thr
    530                 535                 540                 
Asn Pro Thr Pro Gly Gln Asp Gln Ala Gln His Pro Val Ser Pro Ser
545                 550                 555                 560 
Val Thr Val Gln Leu Leu Asp Leu Gly Leu Thr Ile Thr Pro Glu Pro
                565                 570                 575     
Thr Thr Glu Val Gly His Ser Thr Ala Pro Lys Arg Thr Ile Val Ser
            580                 585                 590         
Pro Lys His Pro Glu Val Thr Leu Pro His Pro Asp Gln Val Gln Thr
        595                 600                 605             
Gln His Ser His Leu Thr Arg Ala Thr Val Gln Pro Leu Asp Leu Gly
    610                 615                 620                 
Phe Thr Ile Thr Pro Lys Ser Met Thr Glu Val Glu Pro Ser Thr Ala
625                 630                 635                 640 
Leu Met Thr Thr Ala Pro Pro Pro Gly His Pro Glu Val Thr Leu Pro
                645                 650                 655     
Pro Ser Asp Lys Gly Gln Ala Gln His Ser His Leu Thr Gln Ala Thr
            660                 665                 670         
Val Gln Pro Leu Asp Leu Glu Leu Thr Ile Thr Thr Lys Pro Thr Thr
        675                 680                 685             
Glu Val Lys Pro Ser Pro Thr Thr Glu Glu Thr Ser Thr Gln Pro Pro
    690                 695                 700                 
Asp Leu Gly Leu Ala Ile Ile Pro Glu Pro Thr Thr Glu Thr Gly His
705                 710                 715                 720 
Ser Thr Ala Leu Glu Lys Thr Thr Ala Pro His Pro Asp Arg Val Gln
                725                 730                 735     
Ser Leu His Arg Ser Leu Thr Glu Val Thr Gly Pro Pro Thr Glu Leu
            740                 745                 750         
Glu Pro Ala Gln Asp Ser Leu Val Gln Ser Glu Ser Tyr Thr Gln Asn
        755                 760                 765             
Lys Ala Leu Thr Ala Pro Glu Glu Gln Lys Ala Ser Thr Ser Thr Asn
    770                 775                 780                 
Ile Cys Glu Leu Cys Thr Cys Gly Asp Glu Met Leu Ser Cys Ile Asp
785                 790                 795                 800 
Leu Asn Pro Glu Gln Arg Leu Arg Gln Val Pro Val Pro Glu Pro Asn
                805                 810                 815     
Thr His Asn Gly Thr Phe Thr Ile Leu Asn Phe Gln Gly Asn Tyr Ile
            820                 825                 830         
Ser Tyr Ile Asp Gly Asn Val Trp Lys Ala Tyr Ser Trp Thr Glu Lys
        835                 840                 845             
Leu Ile Leu Arg Glu Asn Asn Leu Thr Glu Leu His Lys Asp Ser Phe
    850                 855                 860                 
Glu Gly Leu Leu Ser Leu Gln Tyr Leu Asp Leu Ser Cys Asn Lys Ile
865                 870                 875                 880 
Gln Ser Ile Glu Arg His Thr Phe Glu Pro Leu Pro Phe Leu Lys Phe
                885                 890                 895     
Ile Asn Leu Ser Cys Asn Val Ile Thr Glu Leu Ser Phe Gly Thr Phe
            900                 905                 910         
Gln Ala Trp His Gly Met Gln Phe Leu His Lys Leu Ile Leu Pro Ser
        915                 920                 925             
His Met Ala Cys Cys Leu Cys Gln Leu Lys Asn Ser Ile Glu Ala Val
    930                 935                 940                 
Cys Lys Thr Val Lys Leu His Cys Asn Ser Ala Cys Leu Thr Asn Thr
945                 950                 955                 960 
Ile His Cys Pro Glu Glu Glu Ser Val Gly Asn Pro Glu Gly Ala Phe
                965                 970                 975     
Met Lys Met Leu Gln Ala Arg Lys Asn Tyr Thr Ser Thr Glu Leu Thr
            980                 985                 990         
Val Glu Pro Glu Glu Pro Ser Asp Ser Ser Gly Ile Asn Leu Ser Gly
        995                 1000                1005            
Phe Gly Arg Asn Ser Leu Ala Lys Ile Gln Thr Val Gly Gln Asn Arg
    1010                1015                1020                
Gln Lys Val Asn Arg Val Leu Met Gly Pro Met Ser Ile Gln Lys Arg
1025                1030                1035                1040
His Phe Lys Glu Val Gly Arg Gln Ser Ile Arg Arg Glu Gln Gly Ala
                1045                1050                1055    
Gln Ala Ser Val Glu Asn Ala Ala Glu Glu Lys Arg Leu Gly Ser Pro
            1060                1065                1070        
Ala Pro Arg Glu Leu Glu Gln Pro His Thr Gln Gln Gly Pro Glu Lys
        1075                1080                1085            
Leu Ala Gly Asn Ala Ile Tyr Thr Lys Pro Ser Phe Ser Gln Glu His
    1090                1095                1100                
Lys Ala Ala Val Ser Val Leu Thr Pro Phe Ser Lys Gly Ala Pro Ser
1105                1110                1115                1120
Thr Ser Ser Pro Ala Lys Ala Leu Pro Gln Met Arg Asp Arg Leu Lys
                1125                1130                1135    
Asp Asn Thr His Tyr Phe His Phe Arg Lys Cys Lys Gly
            1140                1145                


<210> 7439
<211> 283
<212> PRT
<213> Homo sapiens

<400> 7439
Arg Ser Gly Ala Pro Ser Arg Gln Arg Leu Gly Cys Glu Thr Ala Ala
 1               5                  10                  15      
Val Ala Asp Thr Ala Glu Ala Lys Ser Ser Glu Ala Pro Ala Phe Gly
            20                  25                  30          
Trp Ser Thr Met Asp Glu Ala Gly Ser Ser Ala Ser Gly Gly Gly Phe
        35                  40                  45              
Arg Pro Gly Val Asp Ser Leu Asp Glu Pro Pro Asn Ser Arg Ile Phe
    50                  55                  60                  
Leu Val Ile Ser Lys Tyr Thr Pro Glu Ser Val Leu Arg Glu Arg Phe
65                  70                  75                  80  
Ser Pro Phe Gly Asp Ile Gln Asp Ile Trp Val Val Arg Asp Lys His
                85                  90                  95      
Thr Lys Glu Ser Lys Gly Ile Ala Phe Val Lys Phe Ala Arg Ser Ser
            100                 105                 110         
Gln Ala Cys Arg Ala Met Glu Glu Met His Gly Gln Cys Leu Gly Pro
        115                 120                 125             
Asn Asp Thr Lys Pro Ile Lys Val Arg Val Pro Gly Ser Gly Cys Pro
    130                 135                 140                 
Arg Gly Lys Glu Trp Ala Cys Trp Thr Ser Leu His Leu Leu Leu Cys
145                 150                 155                 160 
Arg Gly Glu Gly Gly Val Glu His Pro Phe Pro Ala Ala Asp Gln Thr
                165                 170                 175     
Ala Pro Gly Leu Gly Thr Gly Ala Ala Leu Arg Arg Gly Ser Pro Pro
            180                 185                 190         
Thr Lys Leu Arg Arg Val Ala Gly Lys Gly Thr Gly Cys Gly Val Phe
        195                 200                 205             
Ala Pro Arg Glu Arg Thr Arg Gln Pro Arg Pro Pro Gly Asp Arg Thr
    210                 215                 220                 
Ala Val Ala Gly Leu Pro Leu Ser Leu Ala Leu Thr Asn Pro Pro Ala
225                 230                 235                 240 
Leu Glu Phe Thr Ala Lys Leu Val Leu Ala Tyr Phe Glu Tyr Phe Ser
                245                 250                 255     
Asp Leu Pro Leu Ser Asp Ala Gln Ile Ser Ile Tyr Lys Lys Arg Lys
            260                 265                 270         
Asn Ser Thr Phe Pro Gln Val Gln Met Arg Arg
        275                 280             


<210> 7440
<211> 2109
<212> PRT
<213> Homo sapiens

<400> 7440
Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu
 1               5                  10                  15      
Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Thr Arg Val
            20                  25                  30          
Pro Pro Phe Pro Leu Pro Leu Glu Pro Cys Thr Gln Glu Phe Leu Trp
        35                  40                  45              
Arg Ala Leu Ala Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg
    50                  55                  60                  
Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu
65                  70                  75                  80  
Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Ala Leu Glu Asp
                85                  90                  95      
Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly
            100                 105                 110         
Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asn Ile Thr Asn Asp Ile Arg
        115                 120                 125             
Thr Lys Ser Leu Gln Pro Arg Cys Thr Met Val Glu Pro Phe Asp Arg
    130                 135                 140                 
Trp Gly Lys Lys Leu Ile Ile Gly Ser Leu Pro Ala His Ala Val Gln
145                 150                 155                 160 
Ala Leu Asp Ser Pro Gly Gly Gly Ser Arg Pro Glu Ala Ala Arg Leu
                165                 170                 175     
Leu Leu Leu His Pro Gly Thr Ala Arg Pro Val Gln Val Gln Gly Glu
            180                 185                 190         
Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys
        195                 200                 205             
Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met
    210                 215                 220                 
Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile
225                 230                 235                 240 
Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp
                245                 250                 255     
Ile Leu Met Glu Lys Leu Ser Val Met Leu Ser Thr Arg Thr Asn His
            260                 265                 270         
Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg
        275                 280                 285             
Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys
    290                 295                 300                 
Val Val Ser Leu Arg Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys
305                 310                 315                 320 
Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu
                325                 330                 335     
Lys Glu Phe Lys Arg Asn Asp His Asp Asp Asp Glu Asp Glu Glu Val
            340                 345                 350         
Ile Ser Lys Thr Val Pro Pro Val Asp Ile Val Phe Glu Arg Asp Met
        355                 360                 365             
Leu Thr Gln Thr Tyr Asp Leu Ile Glu Arg Arg Gly Thr Lys Gly Ile
    370                 375                 380                 
Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys Leu Glu Ala
385                 390                 395                 400 
Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val Lys Gly Phe
                405                 410                 415     
Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile Ser Cys Val
            420                 425                 430         
Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Gln Arg Glu Lys Ala
        435                 440                 445             
Arg Ser Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Met Gln Glu Glu
    450                 455                 460                 
Ser Leu Leu Pro Glu Gly Glu Asp Thr Phe Leu Ser Glu Ser Asp Ser
465                 470                 475                 480 
Glu Glu Glu Arg Ser Ser Ser Lys Arg Arg Gly Arg Gly Ser Gln Lys
                485                 490                 495     
Asp Thr Arg Ala Ser Ala Asn Leu Arg Pro Lys Thr Gln Pro His His
            500                 505                 510         
Ser Thr Pro Thr Lys Gly Gly Trp Lys Val Val Asn Leu His Pro Leu
        515                 520                 525             
Lys Lys Gln Pro Pro Ser Phe Pro Gly Ala Ala Glu Glu Arg Ala Cys
    530                 535                 540                 
Gln Ser Leu Ala Ser Arg Asp Ser Leu Leu Asp Thr Ser Ser Val Ser
545                 550                 555                 560 
Glu Pro Asn Val Ser Phe Val Ser His Cys Ala Asp Ser Asn Ser Gly
                565                 570                 575     
Asp Ile Ala Val Ile Glu Glu Val Arg Met Glu Asn Pro Lys Glu Ser
            580                 585                 590         
Ser Ser Ser Leu Lys Thr Gly Arg His Ser Ser Gly Gln Asp Lys Pro
        595                 600                 605             
His Glu Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala
    610                 615                 620                 
Val Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met
625                 630                 635                 640 
Ile Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys
                645                 650                 655     
Lys Ser Ile Val Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu
            660                 665                 670         
Arg Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val
        675                 680                 685             
Asp Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg
    690                 695                 700                 
Ser Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala
705                 710                 715                 720 
Asn Arg Val Lys Thr Ser Gln Pro Pro Val Pro Gln Gly Glu Ala Glu
                725                 730                 735     
Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser Gly Ser Gly Asp Ser Gln
            740                 745                 750         
Leu Ser Ala Ser Ser Arg Ser Glu Ser Gly Arg Met Lys Lys Ser Asp
        755                 760                 765             
Asn Lys Met Gly Ile Thr Pro Leu Arg Asn Tyr His Pro Ile Val Val
    770                 775                 780                 
Pro Gly Leu Gly Arg Ser Leu Gly Phe Leu Pro Lys Met Pro Arg Leu
785                 790                 795                 800 
Arg Val Val His Met Phe Leu Trp Tyr Leu Ile Tyr Gly His Pro Ala
                805                 810                 815     
Ser Asn Thr Val Glu Lys Pro Ser Phe Ile Ser Glu Arg Arg Thr Ile
            820                 825                 830         
Lys Gln Glu Ser Gly Arg Ala Gly Val Arg Pro Ser Ser Ser Gly Ser
        835                 840                 845             
Ala Trp Glu Ala Cys Ser Glu Ala Pro Ser Lys Gly Ser Gln Asp Gly
    850                 855                 860                 
Val Thr Trp Glu Ala Glu Val Glu Leu Ala Thr Glu Thr Val Tyr Val
865                 870                 875                 880 
Asp Asp Ala Ser Trp Met Arg Tyr Ile Pro Pro Ile Pro Val His Arg
                885                 890                 895     
Asp Phe Gly Phe Gly Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu
            900                 905                 910         
Pro Leu Ser Ile Phe Ile Gln Ile Val Gln Val Ser Tyr Lys Val Asp
        915                 920                 925             
Asn Leu Glu Glu Phe Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile
    930                 935                 940                 
Arg Phe Leu Pro Arg Pro Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg
945                 950                 955                 960 
Tyr Ile Phe Ser Val Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly
                965                 970                 975     
Val Leu Gln Phe Gly Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val
            980                 985                 990         
Phe Ile Phe Leu Lys Lys Asn Ala Val Ile Val Asp Thr Thr Ile Cys
        995                 1000                1005            
Asp Pro His Tyr Asn Leu Gly Arg Arg Arg Arg Pro Phe Glu Arg Arg
    1010                1015                1020                
Leu Tyr Val Leu Asn Ser Met Gln Asp Val Glu Asn Tyr Trp Phe Asp
1025                1030                1035                1040
Leu Gln Cys Val Cys Leu Asn Thr Pro Leu Gly Val Val Arg Cys Pro
                1045                1050                1055    
Arg Val Arg Lys Asn Ser Ser Thr Asp Gln Gly Ser Asp Glu Glu Gly
            1060                1065                1070        
Ser Leu Gln Lys Glu Gln Glu Ser Ala Met Asp Lys His Asn Leu Glu
        1075                1080                1085            
Arg Lys Cys Ala Met Leu Glu Tyr Thr Thr Gly Ser Arg Glu Val Val
    1090                1095                1100                
Asp Glu Gly Leu Ile Pro Gly Asp Gly Leu Gly Ala Ala Gly Leu Asp
1105                1110                1115                1120
Ser Ser Phe Tyr Gly His Leu Lys Arg Asn Trp Ile Trp Thr Ser Tyr
                1125                1130                1135    
Ile Ile Asn Gln Ala Lys Lys Glu Asn Thr Ala Ala Glu Asn Gly Leu
            1140                1145                1150        
Thr Val Arg Leu Gln Thr Phe Leu Ser Lys Arg Pro Met Pro Leu Ser
        1155                1160                1165            
Ala Arg Gly Asn Ser Arg Leu Asn Ile Trp Gly Glu Ala Arg Val Gly
    1170                1175                1180                
Ser Glu Leu Cys Ala Gly Trp Glu Glu Gln Phe Glu Val Asp Arg Glu
1185                1190                1195                1200
Pro Ser Leu Asp Arg Asn Arg Arg Val Arg Gly Gly Lys Ser Gln Lys
                1205                1210                1215    
Arg Lys Arg Leu Lys Lys Asp Pro Gly Lys Lys Ile Lys Arg Lys Lys
            1220                1225                1230        
Lys Gly Glu Phe Pro Gly Glu Lys Ser Lys Arg Leu Arg Tyr His Asp
        1235                1240                1245            
Glu Ala Asp Gln Ser Ala Leu His Arg Met Thr Arg Leu Arg Val Thr
    1250                1255                1260                
Trp Ser Met Gln Glu Asp Gly Leu Leu Val Leu Cys Arg Ile Ala Ser
1265                1270                1275                1280
Asn Val Leu Asn Thr Lys Val Lys Gly Pro Phe Val Thr Trp Gln Val
                1285                1290                1295    
Val Arg Asp Ile Leu His Ala Thr Phe Glu Glu Ser Leu Asp Lys Thr
            1300                1305                1310        
Ser His Ser Leu Gly Arg Arg Ala Arg Tyr Ile Val Lys Asn Pro Gln
        1315                1320                1325            
Ala Tyr Leu Asn Tyr Lys Val Cys Leu Ala Glu Val Tyr Gln Asp Lys
    1330                1335                1340                
Ala Leu Val Gly Asp Phe Met Asn Arg Arg Gly Asp Tyr Asp Asp Pro
1345                1350                1355                1360
Lys Val Cys Ala Asn Glu Phe Lys Glu Phe Val Glu Lys Leu Lys Glu
                1365                1370                1375    
Lys Phe Ser Ser Ala Leu Arg Asn Ser Asn Leu Glu Ile Pro Asp Thr
            1380                1385                1390        
Leu Gln Glu Leu Phe Ala Arg Tyr Arg Val Leu Ala Ile Gly Asp Glu
        1395                1400                1405            
Lys Asp Gln Thr Arg Lys Glu Asp Glu Leu Asn Ser Val Asp Asp Ile
    1410                1415                1420                
His Phe Leu Val Leu Gln Asn Leu Ile Gln Ser Thr Leu Ala Leu Ser
1425                1430                1435                1440
Asp Ser Gln Met Lys Ser Tyr Gln Ser Phe Gln Thr Phe Arg Leu Tyr
                1445                1450                1455    
Arg Glu Tyr Lys Asp His Val Leu Val Lys Ala Phe Met Glu Cys Gln
            1460                1465                1470        
Lys Arg Ser Leu Val Asn Arg Arg Arg Val Asn His Thr Leu Gly Pro
        1475                1480                1485            
Lys Lys Asn Arg Ala Leu Pro Phe Val Pro Met Ser Tyr Gln Leu Ser
    1490                1495                1500                
Gln Thr Tyr Tyr Arg Ile Phe Thr Trp Arg Phe Pro Ser Thr Ile Cys
1505                1510                1515                1520
Thr Glu Ser Phe Gln Phe Leu Asp Arg Met Arg Ala Ala Gly Lys Leu
                1525                1530                1535    
Asp Gln Pro Asp Arg Phe Ser Phe Lys Asp Gln Asp Asn Asn Glu Pro
            1540                1545                1550        
Thr Asn Asp Met Val Ala Phe Ser Leu Asp Gly Pro Gly Gly Asn Cys
        1555                1560                1565            
Val Ala Val Leu Thr Leu Phe Ser Leu Gly Leu Ile Ser Val Asp Val
    1570                1575                1580                
Arg Ile Pro Glu Gln Ile Ile Val Val Asp Ser Ser Met Val Glu Asn
1585                1590                1595                1600
Glu Val Ile Lys Ser Leu Gly Lys Asp Gly Ser Leu Glu Asp Asp Glu
                1605                1610                1615    
Asp Glu Glu Asp Asp Leu Asp Glu Gly Val Gly Gly Lys Arg Arg Ser
            1620                1625                1630        
Met Glu Val Lys Pro Ala Gln Ala Ser His Thr Asn Tyr Leu Leu Met
        1635                1640                1645            
Arg Gly Tyr Tyr Ser Pro Gly Ile Val Ser Thr Arg Asn Leu Asn Pro
    1650                1655                1660                
Asn Asp Ser Ile Val Val Asn Ser Cys Gln Met Lys Phe Gln Leu Arg
1665                1670                1675                1680
Cys Thr Pro Val Pro Ala Arg Leu Arg Pro Ala Ala Ala Pro Leu Glu
                1685                1690                1695    
Glu Leu Thr Met Gly Thr Ser Cys Leu Pro Asp Thr Phe Thr Lys Leu
            1700                1705                1710        
Ile Asn Pro Gln Glu Asn Thr Cys Ser Leu Glu Glu Phe Val Leu Gln
        1715                1720                1725            
Leu Glu Leu Ser Gly Tyr Ser Pro Glu Asp Leu Thr Ala Ala Leu Glu
    1730                1735                1740                
Ile Leu Glu Ala Ile Ile Ala Thr Gly Cys Phe Gly Ile Asp Lys Glu
1745                1750                1755                1760
Glu Leu Arg Arg Arg Phe Ser Ala Leu Glu Lys Ala Gly Gly Gly Arg
                1765                1770                1775    
Thr Arg Thr Phe Ala Asp Cys Ile Gln Ala Leu Leu Glu Gln His Gln
            1780                1785                1790        
Val Leu Glu Val Gly Gly Asn Thr Ala Arg Leu Val Ala Met Gly Ser
        1795                1800                1805            
Ala Trp Pro Trp Leu Leu His Ser Val Arg Leu Lys Asp Arg Glu Asp
    1810                1815                1820                
Ala Asp Ile Gln Arg Glu Asp Pro Gln Ala Arg Pro Leu Glu Gly Ser
1825                1830                1835                1840
Ser Ser Glu Asp Ser Pro Pro Glu Gly Gln Ala Pro Pro Ser His Ser
                1845                1850                1855    
Pro Arg Gly Thr Lys Arg Arg Ala Ser Trp Ala Ser Glu Asn Gly Glu
            1860                1865                1870        
Thr Asp Ala Glu Gly Thr Gln Met Thr Pro Ala Lys Arg Pro Ala Leu
        1875                1880                1885            
Gln Asp Ser Asn Leu Ala Pro Ser Leu Gly Pro Gly Ala Glu Asp Gly
    1890                1895                1900                
Ala Glu Ala Gln Ala Pro Ser Pro Pro Pro Ala Leu Glu Asp Thr Ala
1905                1910                1915                1920
Ala Ala Gly Ala Ala Gln Glu Asp Gln Glu Gly Val Gly Glu Phe Ser
                1925                1930                1935    
Ser Pro Gly Gln Glu Gln Leu Ser Gly Gln Ala Gln Pro Pro Glu Gly
            1940                1945                1950        
Ser Glu Asp Pro Arg Gly Phe Thr Glu Ser Phe Gly Ala Ala Asn Ile
        1955                1960                1965            
Ser Gln Ala Ala Arg Glu Arg Asp Cys Glu Ser Val Cys Phe Ile Gly
    1970                1975                1980                
Arg Pro Trp Arg Val Val Asp Gly His Leu Asn Leu Pro Val Cys Lys
1985                1990                1995                2000
Gly Met Met Glu Ala Met Leu Tyr His Ile Met Thr Arg Pro Gly Ile
                2005                2010                2015    
Pro Glu Ser Ser Leu Leu Arg His Tyr Gln Gly Val Leu Gln Pro Val
            2020                2025                2030        
Ala Val Leu Glu Leu Leu Gln Gly Leu Glu Ser Leu Gly Cys Ile Arg
        2035                2040                2045            
Lys Arg Trp Leu Arg Lys Pro Arg Pro Val Ser Leu Phe Ser Thr Pro
    2050                2055                2060                
Val Val Glu Glu Val Glu Val Pro Ser Ser Leu Asp Glu Ser Pro Met
2065                2070                2075                2080
Ala Phe Tyr Glu Pro Thr Leu Asp Cys Thr Leu Arg Leu Gly Arg Val
                2085                2090                2095    
Phe Pro His Glu Val Asn Trp Asn Lys Trp Ile His Leu
            2100                2105                


<210> 7441
<211> 280
<212> PRT
<213> Homo sapiens

<400> 7441
Lys Arg Lys Arg Glu Cys Leu Asp Glu Ser Asp Asp Glu Pro Glu Lys
 1               5                  10                  15      
Glu Leu Ala Pro Glu Pro Glu Glu Thr Trp Val Ala Glu Thr Leu Cys
            20                  25                  30          
Gly Leu Lys Met Lys Ala Lys Arg Arg Arg Val Ser Leu Val Leu Pro
        35                  40                  45              
Glu Tyr Tyr Glu Ala Phe Asn Arg Leu Leu Ala Pro Gly Val Asp Pro
    50                  55                  60                  
Ser Pro Pro Arg Arg Ser Leu Gly Cys Lys Arg Lys Arg Glu Cys Leu
65                  70                  75                  80  
Asp Glu Ser Asp Asp Glu Pro Glu Lys Glu Leu Ala Pro Glu Pro Glu
                85                  90                  95      
Glu Thr Trp Val Ala Glu Thr Leu Cys Gly Leu Lys Met Lys Ala Lys
            100                 105                 110         
Arg Arg Arg Val Ser Leu Val Leu Pro Glu Tyr Tyr Glu Ala Phe Asn
        115                 120                 125             
Arg Leu Leu Glu Asp Pro Val Ile Lys Arg Phe Leu Ala Trp Asp Lys
    130                 135                 140                 
Asp Leu Arg Val Ser Asp Lys Tyr Leu Leu Ala Met Val Ile Ala Tyr
145                 150                 155                 160 
Phe Ser Arg Ala Gly Leu Pro Ser Trp Gln Tyr Gln Arg Ile His Phe
                165                 170                 175     
Phe Leu Ala Leu Tyr Leu Ala Asn Asp Met Glu Glu Asp Asp Glu Ala
            180                 185                 190         
Pro Lys Gln Lys Ile Phe Tyr Phe Leu Tyr Gly Lys Thr His Ser His
        195                 200                 205             
Ile Pro Leu Arg Pro Lys His Trp Phe Gln Leu Cys Arg Pro Met Asn
    210                 215                 220                 
Pro Arg Ala Arg Lys Asn Cys Ser Gln Ile Ala Leu Phe Gln Lys Arg
225                 230                 235                 240 
Arg Phe Gln Phe Phe Cys Ser Met Arg Cys Arg Ala Trp Val Ser Pro
                245                 250                 255     
Glu Glu Leu Glu Glu Ile Gln Ala Tyr Asp Pro Glu His Trp Val Trp
            260                 265                 270         
Ala Arg Asp Arg Ala His Leu Ser
        275                 280 


<210> 7442
<211> 1241
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1009, 1036, 1059, 1085
<223> Xaa = Any Amino Acid

<400> 7442
Met Lys Lys Thr Ser Gly Phe Arg Arg Gly Lys Gly Glu Leu Pro Trp
 1               5                  10                  15      
Gly Ser Val Ser Ser Pro Gly Lys Val Gly Ala Gly Ala Gly Ser Glu
            20                  25                  30          
Ser Glu Asp His Ala Ser Ser Gln Pro Arg Arg His Asp Pro Asp Lys
        35                  40                  45              
Gly Phe Asp Arg Leu Arg Arg Ala Ala Gly Arg His Arg Thr Glu Thr
    50                  55                  60                  
Met Arg Arg Ile Leu Ser Leu Pro Lys Ser Gly Val Asp Asp Arg Asp
65                  70                  75                  80  
Glu Lys Asn Arg Leu Ser Cys Gly Gln Ser Ser Gly Asp Ser Trp Leu
                85                  90                  95      
Ser Val Asp Asp Glu Pro Phe Asp Ser Asp Thr Lys Thr Thr Phe Glu
            100                 105                 110         
Asn Val Pro Gln Lys Tyr Asp Ser Arg Leu Thr Gly Ala Asp Gly Gln
        115                 120                 125             
Arg Gly Lys Ser Thr Ile Lys Glu Gln Glu Ala Leu Asp Phe Asn Ser
    130                 135                 140                 
Leu Thr Phe Ser Asn Glu Leu His Glu Arg Ser Glu Asn Leu Lys Val
145                 150                 155                 160 
Gly Asp Leu Cys Pro Phe Val Ser Pro Pro Met Thr Asn Thr Val Leu
                165                 170                 175     
Gly Ser Thr Asp Leu Gly Gln Lys Asn Leu Ile Asp Gln Glu Lys Met
            180                 185                 190         
Thr Thr Val Gly Ala Leu Leu Phe Trp Asn His Thr Leu Arg Asp Leu
        195                 200                 205             
Cys Glu Ser Gln Leu Pro Glu Asn Lys Asp Ser Lys Glu Glu Gln Asp
    210                 215                 220                 
Leu Glu Val Thr Ser Glu Gln Glu Pro Glu Arg Leu Glu Gly Ser Glu
225                 230                 235                 240 
Asn Asn Lys Pro Gln Ala Glu Gly Glu Arg Lys Thr His Ala Arg Asn
                245                 250                 255     
Glu Thr Glu Ala Ser Arg Asn Leu His Asp Val Ser Thr Asp Asp Arg
            260                 265                 270         
Ile Asp Asn Gly Leu Ile Gln Gln Gly Glu Asn Gly Lys Thr Asp Gly
        275                 280                 285             
Gln Gln Ile Pro Arg Thr Glu Gln Glu Glu Cys Asp Ser Val Pro Ala
    290                 295                 300                 
Leu His Met Lys Lys Val Lys Lys Asn Glu His Glu Glu Trp Thr Thr
305                 310                 315                 320 
Thr Glu Ser Val Thr Ser Leu Val Phe Lys Lys Ala Asp Leu Ile Thr
                325                 330                 335     
Leu Asp Leu Leu Gln Val Thr Asp Glu Ser Ser Leu Thr Glu Ile Asp
            340                 345                 350         
Glu Glu Glu Arg Arg Leu Thr Lys Lys Thr Ser Asn Glu Lys Asp Lys
        355                 360                 365             
Val Arg Asn Gln Ile His Ser Val Asp Gly Phe Asp Asp Leu Thr Trp
    370                 375                 380                 
Ser Ser Glu Ile Ala Ser Glu Cys Cys Glu Leu Pro Tyr Ser Asn Tyr
385                 390                 395                 400 
Lys Lys Phe Ile Leu Leu Ile Glu Glu Leu Gly Val Asp Cys Lys Gly
                405                 410                 415     
Gln Tyr Val Asp Val Thr Ala Lys Thr Ile Gly Lys Gly Phe Gln Gly
            420                 425                 430         
Val Met Lys Arg Trp Gly Phe Lys Gly Gln Pro Ala Thr His Gly Gln
        435                 440                 445             
Thr Lys Thr His Arg Arg Pro Gly Asp Ile Ser Thr Gly Asp Ile Gly
    450                 455                 460                 
Arg Val Trp Pro Gly Thr Lys Met Pro Gly Lys Met Gly Asn Ile Tyr
465                 470                 475                 480 
Arg Thr Val Tyr Gly Leu Lys Val Trp Arg Ile Asn Thr Lys His Asn
                485                 490                 495     
Ile Ile Tyr Val Asn Gly Ser Val Pro Gly His Lys Asn Cys Leu Val
            500                 505                 510         
Arg Val Arg Asp Ser Lys Leu Pro Ala Tyr Lys Asp Leu Gly Lys Asn
        515                 520                 525             
Leu Pro Phe Pro Thr Tyr Phe Pro Asp Gly Asp Glu Glu Glu Leu Pro
    530                 535                 540                 
Glu Asp Leu Tyr Asp Glu Asn Val Cys Gln Pro Asn Pro Val Asn Leu
545                 550                 555                 560 
Leu Lys Ile Gln Asp Ala Val His Ser Trp Glu Arg Ser Ile Glu Val
                565                 570                 575     
Glu Lys Asn His Cys Glu Leu Leu Thr Val Lys Met Lys Lys Met Glu
            580                 585                 590         
Asn Glu Val His Val Leu Gln Lys Glu Leu Ser Glu Thr Thr Glu Ile
        595                 600                 605             
Lys Leu Gln Ser Thr Leu Arg Gln Glu Glu Glu Lys Arg Lys Asn Ala
    610                 615                 620                 
Ser Ala Leu Tyr Glu Lys Ile Arg Gly His Leu Arg Arg Lys Glu Glu
625                 630                 635                 640 
Gln Tyr Arg Lys Glu Val Glu Ala Asn Lys Gln Leu Gln Leu Thr Leu
                645                 650                 655     
Arg Thr Arg Asp Thr Glu Leu Arg Thr Val Arg Asn His Leu Asn Gln
            660                 665                 670         
Val Val Gln Glu Leu Asn Asp Thr Gln Arg Gln Leu Ser Arg Glu Gln
        675                 680                 685             
Asn Ala Arg Ile Leu Gln Asp Glu Ile Leu Thr Asn His Leu Cys Lys
    690                 695                 700                 
Gln Lys Glu Ile Ala Leu Ala Arg Arg Lys Arg Asn Ser Gln Ile Pro
705                 710                 715                 720 
His Ser His Asp Lys Val Gln Asp Leu Leu His Glu Asn Arg Met Leu
                725                 730                 735     
Gln Asp Glu Ile Ala Thr Leu Arg Leu Glu Ile Asp Thr Ile Glu Lys
            740                 745                 750         
Gln Asn Glu Glu Asn Lys Lys Asn Tyr Phe Glu Asp Ile Gly Asp Leu
        755                 760                 765             
Gln Lys Thr Ile Lys Arg Asn Gly Glu Ile Leu Thr Thr Met Ile Ser
    770                 775                 780                 
Glu Tyr Thr Ala Gln Leu Gly Val Leu Thr Ala Glu Asn Thr Met Leu
785                 790                 795                 800 
His Ser Gln Leu Glu Arg Glu Lys Gln Lys Lys Glu Ser Leu Glu Thr
                805                 810                 815     
Glu Val Glu Ser His Arg Cys Arg Leu Ala Ala Val Arg Arg Asp Cys
            820                 825                 830         
Glu Gln Ser Glu Thr Ser Lys Arg Asp Val Glu Leu Ala Phe Gln Gly
        835                 840                 845             
Ala Lys Asp Glu Trp Phe His Leu Pro Glu Lys Met Asn Phe Asp Asp
    850                 855                 860                 
Leu Lys Ala Asn Ser Val Leu Arg Ser Gln Gln Leu Ser Arg Thr Gln
865                 870                 875                 880 
Ser Asn Leu Glu Ser Leu Ser Leu Lys Phe Gln His Thr Arg Asp Ala
                885                 890                 895     
Leu Thr Glu Lys Gln Lys Arg Glu Ala Arg Leu Ser Gln Leu Gln Ser
            900                 905                 910         
Glu Asn Met Leu Leu Pro Gln Gln Leu Asp Asp Ala Tyr Asn Lys Ala
        915                 920                 925             
Asp Asn Gln Glu Lys Thr Ile Ile Thr Ile Gln Asp Gln Ser Arg Ala
    930                 935                 940                 
Thr Val Lys Asn Leu Gln Ala Glu Lys Glu Lys Leu Glu Glu Lys Asn
945                 950                 955                 960 
Gln Thr Leu Ile Asn Glu Cys Asn His Phe Phe Lys Arg Leu Gln Gln
                965                 970                 975     
Gln Gly Asn Glu Lys Ala Glu Arg Glu Ala Ser Leu Glu Val Thr Ser
            980                 985                 990         
His Cys His Ile His Leu Glu Glu Gly Thr Gln Glu Ser Lys Lys Lys
        995                 1000                1005            
Xaa Gly Gln Ile Arg Ser His Val Gln Thr Lys Leu Asn Thr Thr His
    1010                1015                1020                
Glu Arg Val Val Glu Ala Thr Lys Pro Leu Met Xaa Arg Glu Lys Thr
1025                1030                1035                1040
Arg Ser Leu Ser Thr Ala His Ser Thr Arg Pro Val Leu Glu Ser Pro
                1045                1050                1055    
Cys Met Xaa Asn Val Asn Asn Gly Leu Asp Leu Asn Arg Asn His Ile
            1060                1065                1070        
Pro Arg Glu Asn Leu Arg Ile Pro Thr Ser Cys Ser Xaa Thr Ser Asn
        1075                1080                1085            
Asn Ser Val Asp Asp Tyr Leu Phe Lys Asn Ile Glu Glu Gln Thr Glu
    1090                1095                1100                
Ala Phe Leu Asp Ser Ile Ala Ala Arg Ser Leu Lys Ala Ser Glu Lys
1105                1110                1115                1120
Ser Gln Glu Val Cys Val Ser Phe Phe Leu Trp Leu Tyr Thr Phe Phe
                1125                1130                1135    
Thr Ser Thr Val Pro Met Asp Leu Pro Ala Ser Thr Leu Lys Leu Phe
            1140                1145                1150        
Ser Glu Asn Lys Gly Ile Ile Asp Phe Pro Gly Glu Gly Glu Ala Ile
        1155                1160                1165            
Ala Lys Cys His Glu Glu Val Ala Gln Gln Phe Glu Lys Ser Arg Ile
    1170                1175                1180                
Phe Ser Tyr Ile Leu Ser Val Pro Ala Ala Asn His Asn Tyr Met Met
1185                1190                1195                1200
Asp Pro Val Cys Lys Asp Ile Lys Glu Ser Ile Gly Asn Leu Gly Lys
                1205                1210                1215    
Met Glu Pro Glu Met Glu Leu Ile Ser Ile Thr Thr Gly Lys Thr Ala
            1220                1225                1230        
Cys Glu Asp Leu Thr Thr Gly Lys Tyr
        1235                1240    


<210> 7443
<211> 377
<212> PRT
<213> Homo sapiens

<400> 7443
Met Lys Phe Pro Gly Pro Leu Glu Asn Gln Arg Leu Ser Phe Leu Leu
 1               5                  10                  15      
Glu Lys Ala Ile Thr Arg Glu Ala Gln Met Trp Lys Val Asn Val Arg
            20                  25                  30          
Lys Met Pro Ser Asn Gln Asn Val Ser Pro Ser Gln Arg Asp Glu Val
        35                  40                  45              
Ile Gln Trp Leu Ala Lys Leu Lys Tyr Gln Phe Asn Leu Tyr Pro Glu
    50                  55                  60                  
Thr Phe Ala Leu Ala Ser Ser Leu Leu Asp Arg Phe Leu Ala Thr Val
65                  70                  75                  80  
Lys Ala His Pro Lys Tyr Leu Ser Cys Ile Ala Ile Ser Cys Phe Phe
                85                  90                  95      
Leu Ala Ala Lys Thr Val Glu Glu Asp Glu Arg Ile Pro Val Leu Lys
            100                 105                 110         
Val Leu Ala Arg Asp Ser Phe Cys Gly Cys Ser Ser Ser Glu Ile Leu
        115                 120                 125             
Arg Met Glu Arg Ile Ile Leu Asp Lys Leu Asn Trp Asp Leu His Thr
    130                 135                 140                 
Ala Thr Pro Leu Asp Phe Leu His Ile Phe His Ala Ile Ala Val Ser
145                 150                 155                 160 
Thr Arg Pro Gln Leu Leu Phe Ser Leu Pro Lys Leu Ser Pro Ser Gln
                165                 170                 175     
His Leu Ala Val Leu Thr Lys Gln Leu Leu His Cys Met Ala Cys Asn
            180                 185                 190         
Gln Leu Leu Gln Phe Arg Gly Ser Met Leu Ala Leu Ala Met Val Ser
        195                 200                 205             
Leu Glu Met Glu Lys Leu Ile Pro Asp Trp Leu Ser Leu Thr Ile Glu
    210                 215                 220                 
Leu Leu Gln Lys Ala Gln Met Asp Ser Ser Gln Leu Ile His Cys Arg
225                 230                 235                 240 
Glu Leu Val Ala His His Leu Ser Thr Leu Gln Ser Ser Leu Pro Leu
                245                 250                 255     
Asn Ser Val Tyr Val Tyr Arg Pro Leu Lys His Thr Leu Val Thr Cys
            260                 265                 270         
Asp Lys Gly Val Phe Arg Leu His Pro Ser Ser Val Pro Gly Pro Asp
        275                 280                 285             
Phe Ser Lys Asp Asn Ser Lys Pro Glu Val Pro Val Arg Gly Thr Ala
    290                 295                 300                 
Ala Phe Tyr His His Leu Pro Ala Ala Ser Gly Cys Lys Gln Thr Ser
305                 310                 315                 320 
Thr Lys Arg Lys Val Glu Glu Met Glu Val Asp Asp Phe Tyr Asp Gly
                325                 330                 335     
Ile Lys Arg Leu Tyr Asn Glu Asp Asn Val Ser Glu Asn Val Gly Ser
            340                 345                 350         
Val Cys Gly Thr Asp Leu Ser Arg Gln Glu Gly His Ala Ser Pro Cys
        355                 360                 365             
Pro Pro Leu Gln Pro Val Ser Val Met
    370                 375         


<210> 7444
<211> 724
<212> PRT
<213> Homo sapiens

<400> 7444
Met Pro Arg Asn Ser Gly Ala Gly Tyr Gly Cys Pro His Gly Asp Pro
 1               5                  10                  15      
Ser Met Leu Asp Ser Arg Glu Thr Pro Gln Glu Ser Arg Gln Asp Met
            20                  25                  30          
Ile Val Arg Thr Thr Gln Glu Lys Leu Lys Thr Ser Ser Leu Thr Asp
        35                  40                  45              
Arg Gln Pro Leu Ser Lys Glu Ser Leu Asn His Ala Leu Glu Leu Ser
    50                  55                  60                  
Val Pro Glu Lys Val Asn Asn Ala Gln Trp Asp Ala Pro Glu Glu Ala
65                  70                  75                  80  
Leu Trp Thr Thr Arg Ala Asp Gly Arg Val Arg Leu Arg Ile Asp Pro
                85                  90                  95      
Ser Cys Pro Gln Leu Pro Tyr Thr Val His Arg Met Phe Tyr Glu Ala
            100                 105                 110         
Leu Asp Lys Tyr Gly Asp Leu Ile Ala Leu Gly Phe Lys Arg Gln Asp
        115                 120                 125             
Lys Trp Glu His Ile Ser Tyr Ser Gln Tyr Tyr Leu Leu Ala Arg Arg
    130                 135                 140                 
Ala Ala Lys Gly Phe Leu Lys Leu Gly Leu Lys Gln Ala His Ser Val
145                 150                 155                 160 
Ala Ile Leu Gly Phe Asn Ser Pro Glu Trp Phe Phe Ser Ala Val Gly
                165                 170                 175     
Thr Val Phe Ala Gly Gly Ile Val Thr Gly Ile Tyr Thr Thr Ser Ser
            180                 185                 190         
Pro Glu Ala Cys Gln Tyr Ile Ala Tyr Asp Cys Cys Ala Asn Val Ile
        195                 200                 205             
Met Val Asp Thr Gln Lys Gln Leu Glu Lys Ile Leu Lys Ile Trp Lys
    210                 215                 220                 
Gln Leu Pro His Leu Lys Ala Val Val Ile Tyr Lys Glu Pro Pro Pro
225                 230                 235                 240 
Asn Lys Met Ala Asn Val Tyr Thr Met Glu Glu Phe Met Glu Leu Gly
                245                 250                 255     
Asn Glu Val Pro Glu Glu Ala Leu Asp Ala Ile Ile Asp Thr Gln Gln
            260                 265                 270         
Pro Asn Gln Cys Cys Val Leu Val Tyr Thr Ser Gly Thr Thr Gly Asn
        275                 280                 285             
Pro Lys Gly Val Met Leu Ser Gln Asp Asn Ile Thr Trp Thr Ala Arg
    290                 295                 300                 
Tyr Gly Ser Gln Ala Gly Asp Ile Arg Pro Ala Glu Val Gln Gln Glu
305                 310                 315                 320 
Val Val Val Ser Tyr Leu Pro Leu Ser His Ile Ala Ala Gln Ile Tyr
                325                 330                 335     
Asp Leu Trp Thr Gly Ile Gln Trp Gly Ala Gln Val Cys Phe Ala Glu
            340                 345                 350         
Pro Asp Ala Leu Lys Gly Ser Leu Val Asn Thr Leu Arg Glu Val Glu
        355                 360                 365             
Pro Thr Ser His Met Gly Val Pro Arg Val Trp Glu Lys Ile Met Glu
    370                 375                 380                 
Arg Ile Gln Glu Val Ala Ala Gln Ser Gly Phe Ile Arg Arg Lys Met
385                 390                 395                 400 
Leu Leu Trp Ala Met Ser Val Thr Leu Glu Gln Asn Leu Thr Cys Pro
                405                 410                 415     
Gly Ser Asp Leu Lys Pro Phe Thr Thr Arg Leu Ala Asp Tyr Leu Val
            420                 425                 430         
Leu Ala Lys Val Arg Gln Ala Leu Gly Phe Ala Lys Cys Gln Lys Asn
        435                 440                 445             
Phe Tyr Gly Ala Ala Pro Met Met Ala Glu Thr Gln His Phe Phe Leu
    450                 455                 460                 
Gly Leu Asn Ile Arg Leu Tyr Ala Gly Tyr Gly Leu Ser Glu Thr Ser
465                 470                 475                 480 
Gly Pro His Phe Met Ser Ser Pro Tyr Asn Tyr Arg Leu Tyr Ser Ser
                485                 490                 495     
Gly Lys Leu Val Pro Gly Cys Arg Val Lys Leu Val Asn Gln Asp Ala
            500                 505                 510         
Glu Gly Ile Gly Glu Ile Cys Leu Trp Gly Arg Thr Ile Phe Met Gly
        515                 520                 525             
Tyr Leu Asn Met Glu Asp Lys Thr Cys Glu Ala Ile Asp Glu Glu Gly
    530                 535                 540                 
Trp Leu His Thr Gly Asp Ala Gly Arg Leu Asp Ala Asp Gly Phe Leu
545                 550                 555                 560 
Tyr Ile Thr Gly Arg Leu Lys Glu Leu Ile Ile Thr Ala Gly Gly Glu
                565                 570                 575     
Asn Val Pro Pro Val Pro Ile Glu Glu Ala Val Lys Met Glu Leu Pro
            580                 585                 590         
Ile Ile Ser Asn Ala Met Leu Ile Gly Asp Gln Arg Lys Phe Leu Ser
        595                 600                 605             
Met Leu Leu Thr Leu Lys Cys Thr Leu Asp Pro Asp Thr Ser Asp Gln
    610                 615                 620                 
Thr Asp Asn Leu Thr Glu Gln Ala Val Glu Phe Cys Gln Arg Val Gly
625                 630                 635                 640 
Ser Arg Ala Thr Thr Val Ser Glu Ile Ile Glu Lys Lys Asp Glu Ala
                645                 650                 655     
Val Tyr Gln Ala Ile Glu Glu Gly Ile Arg Arg Val Asn Met Asn Ala
            660                 665                 670         
Ala Ala Arg Pro Tyr His Ile Gln Lys Trp Ala Ile Leu Glu Arg Asp
        675                 680                 685             
Phe Ser Ile Ser Gly Gly Glu Leu Gly Pro Thr Met Lys Leu Lys Arg
    690                 695                 700                 
Leu Thr Val Leu Glu Lys Tyr Lys Gly Ile Ile Asp Ser Phe Tyr Gln
705                 710                 715                 720 
Glu Gln Lys Met
                


<210> 7445
<211> 724
<212> PRT
<213> Homo sapiens

<400> 7445
Met Pro Arg Asn Ser Gly Ala Gly Tyr Gly Cys Pro His Gly Asp Pro
 1               5                  10                  15      
Ser Met Leu Asp Ser Arg Glu Thr Pro Gln Glu Ser Arg Gln Asp Met
            20                  25                  30          
Ile Val Arg Thr Thr Gln Glu Lys Leu Lys Thr Ser Ser Leu Thr Asp
        35                  40                  45              
Arg Gln Pro Leu Ser Lys Glu Ser Leu Asn His Ala Leu Glu Leu Ser
    50                  55                  60                  
Val Pro Glu Lys Val Asn Asn Ala Gln Trp Asp Ala Pro Glu Glu Ala
65                  70                  75                  80  
Leu Trp Thr Thr Arg Ala Asp Gly Arg Val Arg Leu Arg Ile Asp Pro
                85                  90                  95      
Ser Cys Pro Gln Leu Pro Tyr Thr Val His Arg Met Phe Tyr Glu Ala
            100                 105                 110         
Leu Asp Lys Tyr Gly Asp Leu Ile Ala Leu Gly Phe Lys Arg Gln Asp
        115                 120                 125             
Lys Trp Glu His Ile Ser Tyr Ser Gln Tyr Tyr Leu Leu Ala Arg Arg
    130                 135                 140                 
Ala Ala Lys Gly Phe Leu Lys Leu Gly Leu Lys Gln Ala His Ser Val
145                 150                 155                 160 
Ala Ile Leu Gly Phe Asn Ser Pro Glu Trp Phe Phe Ser Ala Val Gly
                165                 170                 175     
Thr Val Phe Ala Gly Gly Ile Val Thr Gly Ile Tyr Thr Thr Ser Ser
            180                 185                 190         
Pro Glu Ala Cys Gln Tyr Ile Ala Tyr Asp Cys Cys Ala Asn Val Ile
        195                 200                 205             
Met Val Asp Thr Gln Lys Gln Leu Glu Lys Ile Leu Lys Ile Trp Lys
    210                 215                 220                 
Gln Leu Pro His Leu Lys Ala Val Val Ile Tyr Lys Glu Pro Pro Pro
225                 230                 235                 240 
Asn Lys Met Ala Asn Val Tyr Thr Met Glu Glu Phe Met Glu Leu Gly
                245                 250                 255     
Asn Glu Val Pro Glu Glu Ala Leu Asp Ala Ile Ile Asp Thr Gln Gln
            260                 265                 270         
Pro Asn Gln Cys Cys Val Leu Val Tyr Thr Ser Gly Thr Thr Gly Asn
        275                 280                 285             
Pro Lys Gly Val Met Leu Ser Gln Asp Asn Ile Thr Trp Thr Ala Arg
    290                 295                 300                 
Tyr Gly Ser Gln Ala Gly Asp Ile Arg Pro Ala Glu Val Gln Gln Glu
305                 310                 315                 320 
Val Val Val Ser Tyr Leu Pro Leu Ser His Ile Ala Ala Gln Ile Tyr
                325                 330                 335     
Asp Leu Trp Thr Gly Ile Gln Trp Gly Ala Gln Val Cys Phe Ala Glu
            340                 345                 350         
Pro Asp Ala Leu Lys Gly Ser Leu Val Asn Thr Leu Arg Glu Val Glu
        355                 360                 365             
Pro Thr Ser His Met Gly Val Pro Arg Val Trp Glu Lys Ile Met Glu
    370                 375                 380                 
Arg Ile Gln Glu Val Ala Ala Gln Ser Gly Phe Ile Arg Arg Lys Met
385                 390                 395                 400 
Leu Leu Trp Ala Met Ser Val Thr Leu Glu Gln Asn Leu Thr Cys Pro
                405                 410                 415     
Gly Ser Asp Leu Lys Pro Phe Thr Thr Arg Leu Ala Asp Tyr Leu Val
            420                 425                 430         
Leu Ala Lys Val Arg Gln Ala Leu Gly Phe Ala Lys Cys Gln Lys Asn
        435                 440                 445             
Phe Tyr Gly Ala Ala Pro Met Met Ala Glu Thr Gln His Phe Phe Leu
    450                 455                 460                 
Gly Leu Asn Ile Arg Leu Tyr Ala Gly Tyr Gly Leu Ser Glu Thr Ser
465                 470                 475                 480 
Gly Pro His Phe Met Ser Ser Pro Tyr Asn Tyr Arg Leu Tyr Ser Ser
                485                 490                 495     
Gly Lys Leu Val Pro Gly Cys Arg Val Lys Leu Val Asn Gln Asp Ala
            500                 505                 510         
Glu Gly Ile Gly Glu Ile Cys Leu Trp Gly Arg Thr Ile Phe Met Gly
        515                 520                 525             
Tyr Leu Asn Met Glu Asp Lys Thr Cys Glu Ala Ile Asp Glu Glu Gly
    530                 535                 540                 
Trp Leu His Thr Gly Asp Ala Gly Arg Leu Asp Ala Asp Gly Phe Leu
545                 550                 555                 560 
Tyr Ile Thr Gly Arg Leu Lys Glu Leu Ile Ile Thr Ala Gly Gly Glu
                565                 570                 575     
Asn Val Pro Pro Val Pro Ile Glu Glu Ala Val Lys Met Glu Leu Pro
            580                 585                 590         
Ile Ile Ser Asn Ala Met Leu Ile Gly Asp Gln Arg Lys Phe Leu Ser
        595                 600                 605             
Met Leu Leu Thr Leu Lys Cys Thr Leu Asp Pro Asp Thr Ser Asp Gln
    610                 615                 620                 
Thr Asp Asn Leu Thr Glu Gln Ala Met Glu Phe Cys Gln Arg Val Gly
625                 630                 635                 640 
Ser Arg Ala Thr Thr Val Ser Glu Ile Ile Glu Lys Lys Asp Glu Ala
                645                 650                 655     
Val Tyr Gln Ala Ile Glu Glu Gly Ile Arg Arg Val Asn Met Asn Ala
            660                 665                 670         
Ala Ala Arg Pro Tyr His Ile Gln Lys Trp Ala Ile Leu Glu Arg Asp
        675                 680                 685             
Phe Ser Ile Ser Gly Gly Glu Leu Gly Pro Thr Met Lys Leu Lys Arg
    690                 695                 700                 
Leu Thr Val Leu Glu Lys Tyr Lys Gly Ile Ile Asp Ser Phe Tyr Gln
705                 710                 715                 720 
Glu Gln Lys Met
                


<210> 7446
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 7446
Gly Gly Gly Glu Gly Gly Ile Ala Pro Gly Gly Ala Ser Gly Pro Val
 1               5                  10                  15      
Phe Leu Ser Gly Val Ser Asn Thr Lys Ile Thr Val Gln Lys Glu Ile
            20                  25                  30          
Ala Leu Val Ser Ser Ala Pro Pro Val Pro Asn Thr Met His Gln Pro
        35                  40                  45              
Pro Glu Ser Thr Ala Ala Ala Ala Ala Ala Ala Asp Ile Ser Ala Arg
    50                  55                  60                  
Lys Met Ala His Pro Ala Met Phe Pro Arg Arg Gly Ser Gly Ser Gly
65                  70                  75                  80  
Ser Ala Ser Ala Leu Asn Ala Ala Gly Thr Gly Val Gly Ser Asn Ala
                85                  90                  95      
Thr Ser Ser Glu Asp Phe Pro Pro Pro Ser Leu Leu Gln Pro Pro Pro
            100                 105                 110         
Pro Ala Ala Ser Ser Thr Ser Gly Pro Gln Pro Pro Pro Pro Gln Ser
        115                 120                 125             
Leu Asn Leu Leu Ser Gln Ala Gln Leu Gln Ala Gln Pro Leu Ala Pro
    130                 135                 140                 
Gly Gly Thr Gln Met Lys Lys Lys Ser Gly Phe Gln Ile Thr Ser Val
145                 150                 155                 160 
Thr Pro Ala Gln Ile Ser Ala Ser Ile Ser Ser Asn Asn Ser Ile Ala
                165                 170                 175     
Glu Asp Thr Glu Ser Tyr Asp Asp Leu Asp Glu Ser His Thr Glu Asp
            180                 185                 190         
Leu Ser Ser Ser Glu Ile Leu Asp Val Ser Leu Ser Arg Ala Thr Asp
        195                 200                 205             
Leu Gly Glu Pro Glu Arg Ser Ser Ser Glu Glu Thr Leu Asn Asn Phe
    210                 215                 220                 
Gln Glu Ala Glu Thr Pro Gly Ala Val Ser Pro Asn Gln Pro His Leu
225                 230                 235                 240 
Pro Gln Pro His Leu Pro His Leu Pro Gln Gln Asn Val Val Ile Asn
                245                 250                 255     
Gly Asn Ala His Pro His His Leu His His His His Gln Ile His His
            260                 265                 270         
Gly His His Leu Gln His Gly His His His Pro Ser His Val Ala Val
        275                 280                 285             
Ala Ser Ala Ser Ile Thr Gly Gly Pro Pro Ser Ser Pro Val Ser Arg
    290                 295                 300                 
Lys Leu Ser Thr Thr Gly Ser Ser Asp Ser Ile Thr Pro Val Ala Pro
305                 310                 315                 320 
Thr Ser Ala Val Ser Ser Ser Gly Ser Pro Ala Ser Val Met Thr Asn
                325                 330                 335     
Met Arg Ala Pro Ser Thr Thr Gly Gly Ile Gly Ile Asn Ser Val Thr
            340                 345                 350         
Gly Thr Ser Thr Val Asn Asn Val Asn Ile Thr Ala Val Gly Ser Phe
        355                 360                 365             
Asn Pro Asn Val Thr Ser Ser Ile Leu Gly Asn Val Asn Ile Ser Thr
    370                 375                 380                 
Ser Asn Ile Pro Ser Ala Ala Gly Val Ser Val Gly Pro Gly Val Thr
385                 390                 395                 400 
Ser Gly Val Asn Val Asn Ile Leu Ser Gly Met Gly Asn Gly Thr Ile
                405                 410                 415     
Ser Ser Ser Ala Ala Val Ser Ser Val Pro Asn Ala Ala Ala Gly Met
            420                 425                 430         
Thr Gly Gly Ser Val Ser Ser Gln Gln Gln Gln Pro Thr Val Asn Thr
        435                 440                 445             
Ser Arg Phe Arg Val Val Lys Leu Asp Ser Ser Ser Glu Pro Phe Lys
    450                 455                 460                 
Lys Gly Arg Trp Thr Cys Thr Glu Phe Tyr Glu Lys Glu Asn Ala Val
465                 470                 475                 480 
Pro Ala Thr Glu Gly Val Leu Ile Asn Lys Val Val Glu Thr Val Lys
                485                 490                 495     
Gln Asn Pro Ile Glu Val Thr Ser Glu Arg Glu Ser Thr Ser Gly Ser
            500                 505                 510         
Ser Val Ser Ser Ser Val Ser Thr Leu Ser His Tyr Thr Glu Ser Val
        515                 520                 525             
Gly Ser Gly Glu Met Gly Ala Pro Thr Val Val Val Gln Gln Gln Gln
    530                 535                 540                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Ala Leu Gln Gly Val Thr
545                 550                 555                 560 
Leu Gln Gln Met Asp Phe Gly Ser Thr Gly Pro Gln Ser Ile Pro Ala
                565                 570                 575     
Val Ser Ile Pro Gln Ser Ile Ser Gln Ser Gln Ile Ser Gln Val Gln
            580                 585                 590         
Leu Gln Ser Gln Glu Leu Ser Tyr Gln Gln Lys Gln Gly Leu Gln Pro
        595                 600                 605             
Val Pro Leu Gln Ala Thr Met Ser Ala Ala Thr Gly Ile Gln Pro Ser
    610                 615                 620                 
Pro Val Asn Val Val Gly Val Thr Ser Ala Leu Gly Gln Gln Pro Ser
625                 630                 635                 640 
Ile Ser Ser Leu Ala Gln Pro Gln Leu Pro Tyr Ser Gln Ala Ala Pro
                645                 650                 655     
Pro Val Gln Thr Pro Leu Pro Gly Ala Pro Pro Pro Gln Gln Leu Gln
            660                 665                 670         
Tyr Gly Gln Gln Gln Pro Met Val Ser Thr Gln Met Ala Pro Gly His
        675                 680                 685             
Val Lys Ser Val Thr Gln Asn Pro Ala Ser Glu Tyr Val Gln Gln Gln
    690                 695                 700                 
Pro Ile Leu Gln Thr Ala Met Ser Ser Gly Gln Pro Ser Ser Ala Gly
705                 710                 715                 720 
Val Gly Ala Gly Thr Thr Val Ile Pro Val Ala Gln Pro Gln Gly Ile
                725                 730                 735     
Gln Leu Pro Val Gln Pro Thr Ala Val Pro Ala Gln Pro Ala Gly Ala
            740                 745                 750         
Ser Val Gln Pro Val Gly Gln Ala Pro Ala Ala Val Ser Ala Val Pro
        755                 760                 765             
Thr Gly Ser Gln Ile Ala Asn Ile Gly Gln Gln Ala Asn Ile Pro Thr
    770                 775                 780                 
Ala Val Gln Gln Pro Ser Thr Gln Val Pro Pro Ser Val Ile Gln Gln
785                 790                 795                 800 
Gly Ala Pro Pro Ser Ser Gln Val Val Pro Pro Ala Gln Thr Gly Ile
                805                 810                 815     
Ile His Gln Gly Val Gln Thr Ser Ala Pro Ser Leu Pro Gln Gln Leu
            820                 825                 830         
Val Ile Ala Ser Gln Ser Ser Leu Leu Thr Val Pro Pro Gln Pro Gln
        835                 840                 845             
Gly Val Glu Pro Val Ala Gln Gly Ile Val Ser Gln Gln Leu Pro Ala
    850                 855                 860                 
Val Ser Ser Leu Pro Ser Ala Ser Ser Ile Ser Val Thr Ser Gln Val
865                 870                 875                 880 
Ser Ser Thr Gly Pro Ser Gly Met Pro Ser Ala Pro Thr Asn Leu Val
                885                 890                 895     
Pro Pro Gln Asn Ile Ala Gln Thr Pro Ala Thr Gln Asn Gly Asn Leu
            900                 905                 910         
Val Gln Ser Val Ser Gln Pro Pro Leu Ile Ala Thr Asn Thr Asn Leu
        915                 920                 925             
Pro Leu Ala Gln Gln Ile Pro Leu Ser Ser Thr Gln Phe Ser Ala Gln
    930                 935                 940                 
Ser Leu Ala Gln Ala Ile Gly Ser Gln Ile Glu Asp Ala Arg Arg Ala
945                 950                 955                 960 
Ala Glu Pro Ser Leu Val Gly Leu Pro Gln Thr Ile Ser Gly Asp Ser
                965                 970                 975     
Gly Gly Met Ser Ala Val Ser Asp Gly Ser Ser Ser Ser Leu Ala Ala
            980                 985                 990         
Ser Ala Ser Leu Phe Pro Leu Lys Val Leu Pro Leu Thr Thr Pro Leu
        995                 1000                1005            
Val Asp Gly Glu Asp Glu Ser Ser Ser Gly Ala Ser Val Val Ala Ile
    1010                1015                1020                
Asp Asn Lys Ile Glu Gln Ala Met Asp Leu Val Lys Ser His Leu Met
1025                1030                1035                1040
Tyr Ala Val Arg Glu Glu Val Glu Val Leu Lys Glu Gln Ile Lys Glu
                1045                1050                1055    
Leu Ile Glu Lys Asn Ser Gln Leu Glu Gln Glu Asn Asn Leu Leu Lys
            1060                1065                1070        
Thr Leu Ala Ser Pro Glu Gln Leu Ala Gln Phe Gln Ala Gln Leu Gln
        1075                1080                1085            
Thr Gly Ser Pro Pro Ala Thr Thr Gln Pro Gln Gly Thr Thr Gln Pro
    1090                1095                1100                
Pro Ala Gln Pro Ala Ser Gln Gly Ser Gly Pro Thr Ala
1105                1110                1115        


<210> 7447
<211> 300
<212> PRT
<213> Homo sapiens

<400> 7447
Leu Ser Phe Pro Lys Ala Leu Ser Pro Asp Arg Ile Gln Pro His Ile
 1               5                  10                  15      
Met Thr Asp Val Pro Ala Thr Phe Thr Gln Ala Glu Cys Asn Gly Asp
            20                  25                  30          
Lys Pro Pro Glu Asn Gly Gln Gln Thr Ile Thr Lys Ile Ser Glu Glu
        35                  40                  45              
Leu Thr Asp Val Asp Ser Pro Leu Pro His Tyr Arg Val Glu Pro Ser
    50                  55                  60                  
Leu Glu Gly Ala Leu Thr Lys Gly Ser Gln Glu Glu Arg Arg Lys Leu
65                  70                  75                  80  
Gln Gly Asn Met Leu Leu Asn Ser Ser Met Glu Asp Lys Met Leu Lys
                85                  90                  95      
Glu Asn Pro Glu Glu Lys Leu Phe Ile Val His Lys Ala Ile Thr Asp
            100                 105                 110         
Leu Ser Leu Gln Glu Thr Ser Ala Asp Glu Met Thr Phe Arg Glu Gly
        115                 120                 125             
His Gln Trp Glu Lys Ile Pro Leu Ser Gly Ser Asn Gln Glu Ile Arg
    130                 135                 140                 
Arg Gln Lys Glu Arg Ile Thr Glu Gln Pro Leu Lys Glu Glu Glu Asp
145                 150                 155                 160 
Glu Asp Arg Lys Asn Lys Gly His Gln Ala Ala Glu Ile Glu Trp Leu
                165                 170                 175     
Gly Phe Arg Lys Pro Ser Gln Ala Asp Met Leu His Ser Lys His Asp
            180                 185                 190         
Glu Glu Gln Lys Val Trp Asp Glu Glu Ile Asp Asp Asp Asp Asp Asp
        195                 200                 205             
Asn Cys Asn Asn Asp Glu Asp Glu Val Arg Val Ile Glu Phe Lys Lys
    210                 215                 220                 
Lys His Glu Glu Val Ser Gln Phe Lys Glu Glu Gly Asp Ala Ser Glu
225                 230                 235                 240 
Asp Ser Pro Leu Ser Ser Ala Ser Ser Gln Ala Val Thr Pro Asp Glu
                245                 250                 255     
Gln Pro Thr Leu Gly Lys Lys Ser Asp Ile Ser Arg Asn Ala Tyr Ser
            260                 265                 270         
Arg Tyr Asn Thr Ile Ser Tyr Arg Lys Ile Arg Lys Gly Asn Thr Lys
        275                 280                 285             
Gln Arg Ile Asp Glu Phe Glu Ser Met Met His Leu
    290                 295                 300 


<210> 7448
<211> 640
<212> PRT
<213> Homo sapiens

<400> 7448
Met Ala Ala Gly Gly Thr Gly Gly Leu Arg Glu Glu Gln Arg Tyr Gly
 1               5                  10                  15      
Leu Ser Cys Gly Arg Leu Gly Gln Asp Asn Ile Thr Val Leu His Val
            20                  25                  30          
Lys Leu Thr Glu Thr Ala Ile Arg Ala Leu Glu Thr Tyr Gln Ser His
        35                  40                  45              
Lys Asn Leu Ile Pro Phe Arg Pro Ser Ile Gln Phe Gln Gly Leu His
    50                  55                  60                  
Gly Leu Val Lys Ile Pro Lys Asn Asp Pro Leu Asn Glu Val His Asn
65                  70                  75                  80  
Phe Asn Phe Tyr Leu Ser Asn Val Gly Lys Asp Asn Pro Gln Gly Ser
                85                  90                  95      
Phe Asp Cys Ile Gln Gln Thr Phe Ser Ser Ser Gly Ala Ser Gln Leu
            100                 105                 110         
Asn Cys Leu Gly Phe Ile Gln Asp Lys Ile Thr Val Cys Ala Thr Asn
        115                 120                 125             
Asp Ser Tyr Gln Met Thr Arg Glu Arg Met Thr Gln Ala Glu Glu Glu
    130                 135                 140                 
Ser Arg Asn Arg Ser Thr Lys Val Ile Lys Pro Gly Gly Pro Tyr Val
145                 150                 155                 160 
Gly Lys Arg Val Gln Ile Arg Lys Ala Pro Gln Ala Val Ser Asp Thr
                165                 170                 175     
Val Pro Glu Arg Lys Arg Ser Thr Pro Met Asn Pro Ala Asn Thr Ile
            180                 185                 190         
Arg Lys Thr His Ser Ser Ser Thr Ile Ser Gln Arg Pro Tyr Arg Asp
        195                 200                 205             
Arg Val Ile His Leu Leu Ala Leu Lys Ala Tyr Lys Lys Pro Glu Leu
    210                 215                 220                 
Leu Ala Arg Leu Gln Lys Asp Gly Val Asn Gln Lys Asp Lys Asn Ser
225                 230                 235                 240 
Leu Gly Ala Ile Leu Gln Gln Val Ala Asn Leu Asn Ser Lys Asp Leu
                245                 250                 255     
Ser Tyr Thr Leu Lys Asp Tyr Val Phe Lys Glu Leu Gln Arg Asp Trp
            260                 265                 270         
Pro Gly Tyr Ser Glu Ile Asp Arg Arg Ser Leu Glu Ser Val Leu Ser
        275                 280                 285             
Arg Lys Leu Asn Pro Ser Gln Asn Ala Thr Gly Thr Ser Arg Ser Glu
    290                 295                 300                 
Ser Pro Val Cys Ser Ser Arg Asp Ala Val Ser Ser Pro Gln Lys Arg
305                 310                 315                 320 
Leu Leu Asp Ser Glu Phe Ile Asp Pro Leu Met Asn Lys Lys Ala Arg
                325                 330                 335     
Ile Ser His Leu Thr Asn Arg Val Pro Pro Thr Leu Asn Gly His Leu
            340                 345                 350         
Asn Pro Thr Ser Glu Lys Ser Ala Ala Gly Leu Pro Leu Pro Pro Ala
        355                 360                 365             
Ala Ala Ala Ile Pro Thr Pro Pro Pro Leu Pro Ser Thr Tyr Leu Pro
    370                 375                 380                 
Ile Ser His Pro Pro Gln Ile Val Asn Ser Asn Ser Asn Ser Pro Ser
385                 390                 395                 400 
Thr Pro Glu Gly Arg Gly Thr Gln Asp Leu Pro Val Asp Ser Phe Ser
                405                 410                 415     
Gln Asn Asp Ser Ile Tyr Glu Asp Gln Gln Asp Lys Tyr Thr Ser Arg
            420                 425                 430         
Thr Ser Leu Glu Thr Leu Pro Pro Gly Ser Val Leu Leu Lys Cys Pro
        435                 440                 445             
Lys Pro Met Glu Glu Asn His Ser Met Ser His Lys Lys Ser Lys Lys
    450                 455                 460                 
Lys Ser Lys Lys His Lys Glu Lys Asp Gln Ile Lys Lys His Asp Ile
465                 470                 475                 480 
Glu Thr Ile Glu Glu Lys Glu Glu Asp Leu Lys Arg Glu Glu Glu Ile
                485                 490                 495     
Ala Lys Leu Asn Asn Ser Ser Pro Asn Ser Ser Gly Gly Val Lys Glu
            500                 505                 510         
Asp Cys Thr Ala Ser Met Glu Pro Ser Ala Ile Glu Leu Pro Asp Tyr
        515                 520                 525             
Leu Ile Lys Tyr Ile Ala Ile Val Ser Tyr Glu Gln Arg Gln Asn Tyr
    530                 535                 540                 
Lys Asp Asp Phe Asn Ala Glu Tyr Asp Glu Tyr Arg Ala Leu His Ala
545                 550                 555                 560 
Arg Met Glu Thr Val Ala Arg Arg Phe Ile Lys Leu Asp Ala Gln Arg
                565                 570                 575     
Lys Arg Leu Ser Pro Gly Ser Lys Glu Tyr Gln Asn Val His Glu Glu
            580                 585                 590         
Val Leu Gln Glu Tyr Gln Lys Ile Lys Gln Ser Ser Pro Asn Tyr His
        595                 600                 605             
Glu Glu Lys Tyr Arg Cys Glu Tyr Leu His Asn Lys Leu Ala His Ile
    610                 615                 620                 
Lys Arg Leu Ile Gly Glu Phe Asp Gln Gln Gln Ala Glu Ser Trp Ser
625                 630                 635                 640 


<210> 7449
<211> 730
<212> PRT
<213> Homo sapiens

<400> 7449
Met Leu Phe Asn Ser Val Leu Arg Gln Pro Gln Leu Gly Val Leu Arg
 1               5                  10                  15      
Asn Gly Trp Ser Ser Gln Tyr Pro Leu Gln Ser Leu Leu Thr Gly Tyr
            20                  25                  30          
Gln Cys Ser Gly Asn Asp Glu His Thr Ser Tyr Gly Glu Thr Gly Val
        35                  40                  45              
Pro Val Pro Pro Phe Gly Cys Thr Phe Ser Ser Ala Pro Asn Met Glu
    50                  55                  60                  
His Val Leu Ala Val Ala Asn Glu Glu Gly Phe Val Arg Leu Tyr Asn
65                  70                  75                  80  
Thr Glu Pro Gln Ser Phe Arg Lys Lys Cys Phe Lys Glu Trp Met Ala
                85                  90                  95      
His Trp Asn Ala Val Phe Asp Leu Ala Trp Val Pro Gly Glu Leu Lys
            100                 105                 110         
Leu Val Thr Ala Ala Gly Asp Gln Thr Ala Lys Phe Trp Asp Val Lys
        115                 120                 125             
Ala Gly Glu Leu Ile Gly Thr Cys Lys Gly His Gln Cys Ser Leu Lys
    130                 135                 140                 
Ser Val Ala Phe Ser Lys Phe Glu Lys Ala Val Phe Cys Thr Gly Gly
145                 150                 155                 160 
Arg Asp Gly Asn Ile Met Val Trp Asp Thr Arg Cys Asn Lys Lys Asp
                165                 170                 175     
Gly Phe Tyr Arg Gln Val Asn Gln Ile Ser Gly Ala His Asn Thr Ser
            180                 185                 190         
Asp Lys Gln Thr Pro Ser Lys Pro Lys Lys Lys Gln Asn Ser Lys Gly
        195                 200                 205             
Leu Ala Pro Ser Val Asp Phe Gln Gln Ser Val Thr Val Val Leu Phe
    210                 215                 220                 
Gln Asp Glu Asn Thr Leu Val Ser Ala Gly Ala Val Asp Gly Ile Ile
225                 230                 235                 240 
Lys Val Trp Asp Leu Arg Lys Asn Tyr Thr Ala Tyr Arg Gln Glu Pro
                245                 250                 255     
Ile Ala Ser Lys Ser Phe Leu Tyr Pro Gly Ser Ser Thr Arg Lys Leu
            260                 265                 270         
Gly Tyr Ser Ser Leu Ile Leu Asp Ser Thr Gly Ser Thr Leu Phe Ala
        275                 280                 285             
Asn Cys Thr Asp Asp Asn Ile Tyr Met Phe Asn Met Thr Gly Leu Lys
    290                 295                 300                 
Thr Ser Pro Val Ala Ile Phe Asn Gly His Gln Asn Ser Thr Phe Tyr
305                 310                 315                 320 
Val Lys Ser Ser Leu Ser Pro Asp Asp Gln Phe Leu Val Ser Gly Ser
                325                 330                 335     
Ser Asp Glu Ala Ala Tyr Ile Trp Lys Val Ser Thr Pro Trp Gln Pro
            340                 345                 350         
Pro Thr Val Leu Leu Gly His Ser Gln Glu Val Thr Ser Val Cys Trp
        355                 360                 365             
Cys Pro Ser Asp Phe Thr Lys Ile Ala Thr Cys Ser Asp Asp Asn Thr
    370                 375                 380                 
Leu Lys Ile Trp Arg Leu Asn Arg Gly Leu Glu Glu Lys Pro Gly Gly
385                 390                 395                 400 
Asp Lys Leu Ser Thr Val Gly Trp Ala Ser Gln Lys Lys Lys Glu Ser
                405                 410                 415     
Arg Pro Gly Leu Val Thr Val Thr Ser Ser Gln Ser Thr Pro Ala Lys
            420                 425                 430         
Ala Pro Arg Val Lys Cys Asn Pro Ser Asn Ser Ser Pro Ser Ser Ala
        435                 440                 445             
Ala Cys Ala Pro Ser Cys Ala Gly Asp Leu Pro Leu Pro Ser Asn Thr
    450                 455                 460                 
Pro Thr Phe Ser Ile Lys Thr Ser Pro Ala Lys Ala Arg Ser Pro Ile
465                 470                 475                 480 
Asn Arg Arg Gly Ser Val Ser Ser Val Ser Pro Lys Pro Pro Ser Ser
                485                 490                 495     
Phe Lys Met Ser Ile Arg Asn Trp Val Thr Arg Thr Pro Ser Ser Ser
            500                 505                 510         
Pro Pro Ile Thr Pro Pro Ala Ser Glu Thr Lys Ile Met Ser Pro Arg
        515                 520                 525             
Lys Ala Leu Ile Pro Val Ser Gln Lys Ser Ser Gln Ala Glu Ala Cys
    530                 535                 540                 
Ser Glu Ser Arg Asn Arg Val Lys Arg Arg Leu Asp Ser Ser Cys Leu
545                 550                 555                 560 
Glu Ser Val Lys Gln Lys Cys Val Lys Ser Cys Asn Cys Val Thr Glu
                565                 570                 575     
Leu Asp Gly Gln Val Glu Asn Leu His Leu Asp Leu Cys Cys Leu Ala
            580                 585                 590         
Gly Asn Gln Glu Asp Leu Ser Lys Asp Ser Leu Gly Pro Thr Lys Ser
        595                 600                 605             
Ser Lys Ile Glu Gly Ala Gly Thr Ser Ile Ser Glu Pro Pro Ser Pro
    610                 615                 620                 
Ile Ser Pro Tyr Ala Ser Glu Ser Cys Gly Thr Leu Pro Leu Pro Leu
625                 630                 635                 640 
Arg Pro Cys Gly Glu Gly Ser Glu Met Val Gly Lys Glu Asn Ser Ser
                645                 650                 655     
Pro Glu Asn Lys Asn Trp Leu Leu Ala Met Ala Ala Lys Arg Lys Ala
            660                 665                 670         
Glu Asn Pro Ser Pro Arg Ser Pro Ser Ser Gln Thr Pro Asn Ser Arg
        675                 680                 685             
Arg Gln Ser Gly Lys Thr Leu Pro Ser Pro Val Thr Ile Thr Pro Ser
    690                 695                 700                 
Ser Met Arg Lys Ile Cys Thr Tyr Phe His Arg Lys Ser Gln Glu Asp
705                 710                 715                 720 
Phe Cys Gly Pro Glu His Ser Thr Glu Leu
                725                 730 


<210> 7450
<211> 730
<212> PRT
<213> Homo sapiens

<400> 7450
Met Leu Phe Asn Ser Val Leu Arg Gln Pro Gln Leu Gly Val Leu Arg
 1               5                  10                  15      
Asn Gly Trp Ser Ser Gln Tyr Pro Leu Gln Ser Leu Leu Thr Gly Tyr
            20                  25                  30          
Gln Cys Ser Gly Asn Asp Glu His Thr Ser Tyr Gly Glu Thr Gly Val
        35                  40                  45              
Pro Val Pro Pro Phe Gly Cys Thr Phe Ser Ser Ala Pro Asn Met Glu
    50                  55                  60                  
His Val Leu Ala Val Ala Asn Glu Glu Gly Phe Val Arg Leu Tyr Asn
65                  70                  75                  80  
Thr Glu Ser Gln Ser Phe Arg Lys Lys Cys Phe Lys Glu Trp Met Ala
                85                  90                  95      
His Trp Asn Ala Val Phe Asp Leu Ala Trp Val Pro Gly Glu Leu Lys
            100                 105                 110         
Leu Val Thr Ala Ala Gly Asp Gln Thr Ala Lys Phe Trp Asp Val Lys
        115                 120                 125             
Ala Gly Glu Leu Ile Gly Thr Cys Lys Gly His Gln Cys Ser Leu Lys
    130                 135                 140                 
Ser Val Ala Phe Ser Lys Phe Glu Lys Ala Val Phe Cys Thr Gly Gly
145                 150                 155                 160 
Arg Asp Gly Asn Ile Met Val Trp Asp Thr Arg Cys Asn Lys Lys Asp
                165                 170                 175     
Gly Phe Tyr Arg Gln Val Asn Gln Ile Ser Gly Ala His Asn Thr Ser
            180                 185                 190         
Asp Lys Gln Thr Pro Ser Lys Pro Lys Lys Lys Gln Asn Ser Lys Gly
        195                 200                 205             
Leu Ala Pro Ser Val Asp Phe Gln Gln Ser Val Thr Val Val Leu Phe
    210                 215                 220                 
Gln Asp Glu Asn Thr Leu Val Ser Ala Gly Ala Val Asp Gly Ile Ile
225                 230                 235                 240 
Lys Val Trp Asp Leu Arg Lys Asn Tyr Thr Ala Tyr Arg Gln Glu Pro
                245                 250                 255     
Ile Ala Ser Lys Ser Phe Leu Tyr Pro Gly Ser Ser Thr Arg Lys Leu
            260                 265                 270         
Gly Tyr Ser Ser Leu Ile Leu Asp Ser Thr Gly Ser Thr Leu Phe Ala
        275                 280                 285             
Asn Cys Thr Asp Asp Asn Ile Tyr Met Phe Asn Met Thr Gly Leu Lys
    290                 295                 300                 
Thr Ser Pro Val Ala Ile Phe Asn Gly His Gln Asn Ser Thr Phe Tyr
305                 310                 315                 320 
Val Lys Ser Ser Leu Ser Pro Asp Asp Gln Phe Leu Val Ser Gly Ser
                325                 330                 335     
Ser Asp Glu Ala Ala Tyr Ile Trp Lys Val Ser Thr Pro Trp Gln Pro
            340                 345                 350         
Pro Thr Val Leu Leu Gly His Ser Gln Glu Val Thr Ser Val Cys Trp
        355                 360                 365             
Cys Pro Ser Asp Phe Thr Lys Ile Ala Thr Cys Ser Asp Asp Asn Thr
    370                 375                 380                 
Leu Lys Ile Trp Arg Leu Asn Arg Gly Leu Glu Glu Lys Pro Gly Gly
385                 390                 395                 400 
Asp Lys Leu Ser Thr Val Gly Trp Ala Ser Gln Lys Lys Lys Glu Ser
                405                 410                 415     
Arg Pro Gly Leu Val Thr Val Thr Ser Ser Gln Ser Thr Pro Ala Lys
            420                 425                 430         
Ala Pro Arg Val Lys Cys Asn Pro Ser Asn Ser Ser Pro Ser Ser Ala
        435                 440                 445             
Ala Cys Ala Pro Ser Cys Ala Gly Asp Leu Pro Leu Pro Ser Asn Thr
    450                 455                 460                 
Pro Thr Phe Ser Ile Lys Thr Ser Pro Ala Lys Ala Arg Ser Pro Ile
465                 470                 475                 480 
Asn Arg Arg Gly Ser Val Ser Ser Val Ser Pro Lys Pro Pro Ser Ser
                485                 490                 495     
Phe Lys Met Ser Ile Arg Asn Trp Val Thr Arg Thr Pro Ser Ser Ser
            500                 505                 510         
Pro Pro Ile Thr Pro Pro Ala Ser Glu Thr Lys Ile Met Ser Pro Arg
        515                 520                 525             
Lys Ala Leu Ile Pro Val Ser Gln Lys Ser Ser Gln Ala Glu Ala Cys
    530                 535                 540                 
Ser Glu Ser Arg Asn Arg Val Lys Arg Arg Leu Asp Ser Ser Cys Leu
545                 550                 555                 560 
Glu Ser Val Lys Gln Lys Cys Val Lys Ser Cys Asn Cys Val Thr Glu
                565                 570                 575     
Leu Asp Gly Gln Val Glu Asn Leu His Leu Asp Leu Cys Cys Leu Ala
            580                 585                 590         
Gly Asn Gln Glu Asp Leu Ser Lys Asp Ser Leu Gly Pro Thr Lys Ser
        595                 600                 605             
Ser Lys Ile Glu Gly Ala Gly Thr Ser Ile Ser Glu Pro Pro Ser Pro
    610                 615                 620                 
Ile Ser Pro Tyr Ala Ser Glu Ser Cys Gly Thr Leu Pro Leu Pro Leu
625                 630                 635                 640 
Arg Pro Cys Gly Glu Gly Ser Glu Met Val Gly Lys Glu Asn Ser Ser
                645                 650                 655     
Pro Glu Asn Lys Asn Trp Leu Leu Ala Met Ala Ala Lys Arg Lys Ala
            660                 665                 670         
Glu Asn Pro Ser Pro Arg Ser Pro Ser Ser Gln Thr Pro Asn Ser Arg
        675                 680                 685             
Arg Gln Ser Gly Lys Thr Leu Pro Ser Pro Val Thr Ile Thr Pro Ser
    690                 695                 700                 
Ser Met Arg Lys Ile Cys Thr Tyr Phe His Arg Lys Ser Gln Glu Asp
705                 710                 715                 720 
Phe Cys Gly Pro Glu His Ser Thr Glu Leu
                725                 730 


<210> 7451
<211> 387
<212> PRT
<213> Homo sapiens

<400> 7451
Met Val Cys Gly Ile Gln Glu Ala Ala Glu Asn Tyr Arg Lys Leu Phe
 1               5                  10                  15      
Gln Glu Ile Leu Asn Thr Ser Arg Glu Lys Leu Glu Ala Ala Lys Ser
            20                  25                  30          
Ile Leu Thr Asp Glu Gln Glu Arg Met Ala Met Ile Gln Glu Glu Glu
        35                  40                  45              
Gln Asn Phe Lys Lys Met Ile Glu Ser Glu Tyr Ser Met Arg Leu Arg
    50                  55                  60                  
Leu Leu Asn Glu Glu Cys Glu Gln Asn Leu Gln Arg Gln Gln Glu Cys
65                  70                  75                  80  
Ile Ser Asp Leu Asn Leu Arg Glu Thr Leu Leu Asn Gln Ala Ile Lys
                85                  90                  95      
Leu Ala Thr Glu Leu Glu Glu Met Phe Gln Glu Met Leu Gln Arg Leu
            100                 105                 110         
Gly Arg Val Gly Arg Glu Asn Met Glu Lys Leu Lys Glu Ser Glu Ala
        115                 120                 125             
Arg Ala Ser Glu Gln Val Arg Ser Leu Leu Lys Leu Ile Val Glu Leu
    130                 135                 140                 
Glu Lys Lys Cys Gly Glu Gly Thr Leu Ala Leu Leu Lys Asn Ala Lys
145                 150                 155                 160 
Tyr Ser Leu Glu Arg Ser Lys Ser Leu Leu Leu Glu His Leu Glu Pro
                165                 170                 175     
Ala His Ile Thr Asp Leu Ser Leu Cys His Ile Arg Gly Leu Ser Ser
            180                 185                 190         
Met Phe Arg Val Leu Gln Arg His Leu Thr Leu Asp Pro Glu Thr Ala
        195                 200                 205             
His Pro Cys Leu Ala Leu Ser Glu Asp Leu Arg Thr Met Arg Leu Arg
    210                 215                 220                 
His Gly Gln Gln Asp Gly Ala Gly Asn Pro Glu Arg Leu Asp Phe Ser
225                 230                 235                 240 
Ala Met Val Leu Ala Ala Glu Ser Phe Thr Ser Gly Arg His Tyr Trp
                245                 250                 255     
Glu Val Asp Val Glu Lys Ala Thr Arg Trp Gln Val Gly Ile Tyr His
            260                 265                 270         
Gly Ser Ala Asp Ala Lys Gly Ser Thr Ala Arg Ala Ser Gly Glu Lys
        275                 280                 285             
Val Leu Leu Thr Gly Ser Val Met Gly Thr Glu Trp Thr Leu Trp Val
    290                 295                 300                 
Phe Pro Pro Leu Lys Arg Leu Phe Leu Glu Lys Lys Leu Asp Thr Val
305                 310                 315                 320 
Gly Val Phe Leu Asp Cys Glu His Gly Gln Ile Ser Phe Tyr Asn Val
                325                 330                 335     
Thr Glu Met Ser Leu Ile Tyr Asn Phe Ser His Cys Ala Phe Gln Gly
            340                 345                 350         
Ala Leu Arg Pro Val Phe Ser Leu Cys Ile Pro Asn Gly Asp Thr Ser
        355                 360                 365             
Pro Asp Ser Leu Thr Ile Leu Gln His Gly Pro Ser Cys Asp Ala Thr
    370                 375                 380                 
Val Ser Pro
385         


<210> 7452
<211> 1561
<212> PRT
<213> Homo sapiens

<400> 7452
Met Asn Pro Arg Glu Glu Lys Val Lys Ile Ile Thr Glu Glu Phe Ile
 1               5                  10                  15      
Glu Asn Asp Glu Asp Ala Asp Met Gly Arg Gln Asn Lys Asn Ser Lys
            20                  25                  30          
Val Arg Arg Gln Pro Arg Lys Lys Gln Pro Pro Thr Ala Val Pro Lys
        35                  40                  45              
Glu Met Val Ser Glu Lys Ser His Leu Gly Asn Pro Gln Glu Pro Val
    50                  55                  60                  
Gln Glu Glu Pro Lys Thr Arg Leu Leu Ser Met Thr Val Arg Arg Gly
65                  70                  75                  80  
Pro Arg Ser Leu Pro Pro Ile Pro Ser Thr Ser Arg Thr Gly Phe Ala
                85                  90                  95      
Glu Phe Ser Met Arg Gly Arg Met Arg Glu Lys Leu Gln Ala Ala Arg
            100                 105                 110         
Ser Lys Ala Glu Ser Ala Leu Leu Gln Glu Ile Pro Thr Pro Arg Pro
        115                 120                 125             
Arg Arg Leu Arg Ser Pro Ser Lys Lys Glu Leu Glu Thr Glu Phe Gly
    130                 135                 140                 
Thr Glu Pro Gly Lys Glu Val Glu Arg Thr Gln Gln Glu Val Asp Ser
145                 150                 155                 160 
Gln Ser Tyr Ser Arg Val Lys Phe His Asp Ser Ala Arg Lys Ile Lys
                165                 170                 175     
Pro Lys Pro Gln Val Pro Pro Gly Phe Pro Ser Ala Glu Glu Ala Tyr
            180                 185                 190         
Asn Phe Phe Thr Phe Asn Phe Asp Pro Glu Pro Glu Gly Ser Glu Glu
        195                 200                 205             
Lys Pro Lys Ala Arg His Arg Ala Gly Thr Asn Gln Glu Glu Glu Glu
    210                 215                 220                 
Gly Glu Glu Glu Glu Pro Pro Ala Gln Gly Gly Gly Lys Glu Met Asp
225                 230                 235                 240 
Glu Glu Glu Leu Leu Asn Gly Asp Asp Ala Glu Asp Phe Leu Leu Gly
                245                 250                 255     
Leu Asp His Val Ala Asp Asp Phe Val Ala Val Arg Pro Ala Asp Tyr
            260                 265                 270         
Glu Ser Ile His Asp Arg Leu Gln Met Glu Arg Glu Met Leu Phe Ile
        275                 280                 285             
Pro Ser Arg Gln Thr Val Pro Thr Tyr Lys Lys Leu Pro Glu Asn Val
    290                 295                 300                 
Gln Pro Arg Phe Leu Glu Asp Glu Gly Leu Tyr Thr Gly Val Arg Pro
305                 310                 315                 320 
Glu Val Ala Arg Thr Asn Gln Asn Ile Met Glu Asn Arg Leu Leu Met
                325                 330                 335     
Gln Asp Pro Glu Arg Arg Trp Phe Gly Asp Asp Gly Arg Ile Leu Ala
            340                 345                 350         
Leu Pro Asn Pro Ile Lys Pro Phe Pro Ser Arg Pro Pro Val Leu Thr
        355                 360                 365             
Gln Glu Gln Ser Ile Lys Ala Glu Leu Glu Thr Leu Tyr Lys Lys Ala
    370                 375                 380                 
Val Lys Tyr Val His Ser Ser Gln His Val Ile Arg Ser Gly Asp Pro
385                 390                 395                 400 
Pro Gly Asn Phe Gln Leu Asp Ile Asp Ile Ser Gly Leu Ile Phe Thr
                405                 410                 415     
His His Pro Cys Phe Ser Arg Glu His Val Leu Ala Ala Lys Leu Ala
            420                 425                 430         
Gln Leu Tyr Asp Gln Tyr Leu Ala Arg His Gln Arg Asn Lys Ala Lys
        435                 440                 445             
Phe Leu Thr Asp Lys Leu Gln Ala Leu Arg Asn Ala Val Gln Thr Gly
    450                 455                 460                 
Leu Asp Pro Glu Lys Pro His Gln Ser Leu Asp Thr Ile Gln Lys Thr
465                 470                 475                 480 
Ile Asn Glu Tyr Lys Ser Glu Ile Arg Gln Thr Arg Lys Phe Arg Asp
                485                 490                 495     
Ala Glu Gln Glu Lys Asp Arg Thr Leu Leu Lys Thr Ile Ile Lys Val
            500                 505                 510         
Trp Lys Glu Met Lys Ser Leu Arg Glu Phe Gln Arg Phe Thr Asn Thr
        515                 520                 525             
Pro Leu Lys Leu Val Leu Arg Lys Glu Lys Ala Asp Gln Lys Ala Asp
    530                 535                 540                 
Glu Glu Ala Tyr Glu Ala Glu Ile Gln Ala Glu Ile Ser Glu Leu Leu
545                 550                 555                 560 
Glu Glu His Thr Glu Glu Tyr Ala Gln Lys Met Glu Glu Tyr Arg Thr
                565                 570                 575     
Ser Leu Gln Gln Trp Lys Ala Trp Arg Lys Val Gln Arg Ala Lys Lys
            580                 585                 590         
Lys Lys Arg Lys Gln Ala Ala Glu Glu His Pro Gly Asp Glu Ile Ala
        595                 600                 605             
Glu Pro Tyr Pro Glu Glu Asp Leu Val Lys Pro Ser Pro Pro Glu Pro
    610                 615                 620                 
Thr Asp Arg Ala Val Ile Glu Gln Glu Val Arg Glu Arg Ala Ala Gln
625                 630                 635                 640 
Ser Arg Arg Arg Pro Trp Glu Pro Thr Leu Val Pro Glu Leu Ser Leu
                645                 650                 655     
Ala Gly Ser Val Thr Pro Asn Asp Gln Cys Pro Arg Ala Glu Val Ser
            660                 665                 670         
Arg Arg Glu Asp Val Lys Lys Arg Ser Val Tyr Leu Lys Val Leu Phe
        675                 680                 685             
Asn Asn Lys Glu Val Ser Arg Thr Val Ser Arg Pro Leu Gly Ala Asp
    690                 695                 700                 
Phe Arg Val His Phe Gly Gln Ile Phe Asn Leu Gln Ile Val Asn Trp
705                 710                 715                 720 
Pro Glu Ser Leu Thr Leu Gln Val Tyr Glu Thr Val Gly His Ser Ser
                725                 730                 735     
Pro Thr Leu Leu Ala Glu Val Phe Leu Pro Ile Pro Glu Thr Thr Val
            740                 745                 750         
Val Thr Gly Arg Ala Pro Thr Glu Glu Val Glu Phe Ser Ser Asn Gln
        755                 760                 765             
His Val Thr Leu Asp His Glu Gly Val Gly Ser Gly Val Pro Phe Ser
    770                 775                 780                 
Phe Glu Ala Asp Gly Ser Asn Gln Leu Thr Leu Met Thr Ser Gly Lys
785                 790                 795                 800 
Val Ser His Ser Val Ala Trp Ala Ile Gly Glu Asn Gly Ile Pro Leu
                805                 810                 815     
Ile Pro Pro Leu Ser Gln Gln Asn Ile Gly Phe Arg Ser Ala Leu Lys
            820                 825                 830         
Lys Ala Asp Ala Ile Ser Ser Ile Gly Thr Ser Gly Leu Thr Asp Met
        835                 840                 845             
Lys Lys Leu Ala Lys Trp Ala Ala Glu Ser Lys Leu Asp Pro Asn Asp
    850                 855                 860                 
Pro Asn Asn Ala Pro Leu Met Gln Leu Ile Ser Val Ala Thr Ser Gly
865                 870                 875                 880 
Glu Ser Tyr Val Pro Asp Phe Phe Arg Leu Glu Gln Leu Gln Gln Glu
                885                 890                 895     
Phe Asn Phe Val Ser Asp Gln Glu Leu Asn Arg Ser Lys Arg Phe Arg
            900                 905                 910         
Leu Leu His Leu Arg Ser Gln Glu Val Pro Glu Phe Arg Asn Tyr Lys
        915                 920                 925             
Gln Val Pro Val Tyr Asp Arg Glu Ile Met Glu Lys Val Phe Gln Asp
    930                 935                 940                 
Tyr Glu Lys Arg Leu Arg Asp Arg Asn Val Ile Glu Thr Lys Glu His
945                 950                 955                 960 
Ile Asp Thr His Arg Ala Ile Val Ala Lys Tyr Leu Gln Gln Val Arg
                965                 970                 975     
Glu Ser Val Ile Asn Arg Phe Leu Ile Ala Lys Gln Tyr Phe Leu Leu
            980                 985                 990         
Ala Asp Met Ile Val Glu Glu Glu Val Pro Asn Ile Ser Ile Leu Gly
        995                 1000                1005            
Leu Ser Leu Phe Lys Leu Ala Glu Gln Lys Arg Pro Leu Arg Pro Arg
    1010                1015                1020                
Arg Lys Gly Arg Lys Lys Val Thr Ala Gln Asn Leu Ser Asp Gly Asp
1025                1030                1035                1040
Ile Lys Leu Leu Val Asn Ile Val Arg Ala Tyr Asp Ile Pro Val Arg
                1045                1050                1055    
Lys Pro Ala Val Ser Lys Phe Gln Gln Pro Ser Arg Ser Ser Arg Met
            1060                1065                1070        
Phe Ser Glu Lys His Ala Ala Ser Pro Ser Thr Tyr Ser Pro Thr His
        1075                1080                1085            
Asn Ala Asp Tyr Pro Leu Gly Gln Val Leu Val Arg Pro Phe Val Glu
    1090                1095                1100                
Val Ser Phe Gln Arg Thr Val Cys His Thr Thr Thr Ala Glu Gly Pro
1105                1110                1115                1120
Asn Pro Ser Trp Asn Glu Glu Leu Glu Leu Pro Phe Arg Ala Pro Asn
                1125                1130                1135    
Gly Asp Tyr Ser Thr Ala Ser Leu Gln Ser Val Lys Asp Val Val Phe
            1140                1145                1150        
Ile Asn Ile Phe Asp Glu Val Leu His Asp Val Leu Glu Asp Asp Arg
        1155                1160                1165            
Glu Arg Gly Ser Gly Ile His Thr Arg Ile Glu Arg His Trp Leu Gly
    1170                1175                1180                
Cys Val Lys Met Pro Phe Ser Thr Ile Tyr Phe Gln Ala Arg Phe Glu
1185                1190                1195                1200
Ser Gln Glu Asp Glu Lys Leu Leu Gln Ala Thr Glu Lys Phe Gln Ala
                1205                1210                1215    
Glu Cys Ala Leu Lys Phe Pro Asn Arg Gln Cys Leu Thr Thr Val Ile
            1220                1225                1230        
Asp Ile Ser Gly Lys Thr Val Phe Ile Thr Arg Tyr Leu Lys Pro Leu
        1235                1240                1245            
Asn Pro Pro Gln Glu Leu Leu Asn Val Tyr Pro Asn Asn Leu Gln Ala
    1250                1255                1260                
Thr Ala Glu Leu Val Ala Arg Tyr Val Ser Leu Ile Pro Phe Leu Pro
1265                1270                1275                1280
Asp Thr Val Ser Phe Gly Gly Ile Cys Asp Leu Trp Ser Thr Ser Asp
                1285                1290                1295    
Gln Phe Leu Asp Leu Leu Ala Gly Asp Glu Glu Glu His Ala Val Leu
            1300                1305                1310        
Leu Cys Asn Tyr Phe Leu Ser Leu Gly Lys Lys Ala Trp Leu Leu Met
        1315                1320                1325            
Gly Asn Ala Ile Pro Glu Gly Pro Thr Ala Tyr Val Leu Thr Trp Glu
    1330                1335                1340                
Gln Gly Arg Tyr Leu Ile Trp Asn Pro Cys Ser Gly His Phe Tyr Gly
1345                1350                1355                1360
Gln Phe Asp Thr Phe Cys Pro Leu Lys Asn Val Gly Cys Leu Ile Gly
                1365                1370                1375    
Pro Asp Asn Ile Trp Phe Asn Ile Gln Arg Tyr Glu Ser Pro Leu Arg
            1380                1385                1390        
Ile Asn Phe Asp Val Thr Arg Pro Lys Leu Trp Lys Ser Phe Phe Ser
        1395                1400                1405            
Arg Ser Leu Pro Tyr Pro Gly Leu Ser Ser Val Gln Pro Glu Glu Leu
    1410                1415                1420                
Ile Tyr Gln Arg Ser Asp Lys Ala Ala Ala Ala Glu Leu Gln Asp Arg
1425                1430                1435                1440
Ile Glu Lys Ile Leu Lys Glu Lys Ile Met Asp Trp Arg Pro Arg His
                1445                1450                1455    
Leu Thr Arg Trp Asn Arg Tyr Cys Thr Ser Thr Leu Arg His Phe Leu
            1460                1465                1470        
Pro Leu Leu Glu Lys Ser Gln Gly Glu Asp Val Glu Asp Asp His Arg
        1475                1480                1485            
Ala Glu Leu Leu Lys Gln Leu Gly Asp Tyr Arg Phe Ser Gly Phe Pro
    1490                1495                1500                
Leu His Met Pro Tyr Ser Glu Val Lys Pro Leu Ile Asp Ala Val Tyr
1505                1510                1515                1520
Ser Thr Gly Val His Asn Ile Asp Val Pro Asn Val Glu Phe Ala Leu
                1525                1530                1535    
Ala Val Tyr Ile His Pro Tyr Pro Lys Asn Val Leu Ser Val Trp Ile
            1540                1545                1550        
Tyr Val Ala Ser Leu Ile Arg Asn Arg
        1555                1560    


<210> 7453
<211> 416
<212> PRT
<213> Homo sapiens

<400> 7453
Met Ala Glu Glu Gln Gly Arg Glu Arg Asp Ser Val Pro Lys Pro Ser
 1               5                  10                  15      
Val Leu Phe Leu His Pro Asp Leu Gly Val Gly Gly Ala Glu Arg Leu
            20                  25                  30          
Val Leu Asp Ala Ala Leu Ala Leu Gln Ala Arg Gly Cys Ser Val Lys
        35                  40                  45              
Ile Trp Thr Ala His Tyr Asp Pro Gly His Cys Phe Ala Glu Ser Arg
    50                  55                  60                  
Glu Leu Pro Val Arg Cys Ala Gly Asp Trp Leu Pro Arg Gly Leu Gly
65                  70                  75                  80  
Trp Gly Gly Arg Gly Ala Ala Val Cys Ala Tyr Val Arg Met Val Phe
                85                  90                  95      
Leu Ala Leu Tyr Val Leu Phe Leu Ala Asp Glu Glu Phe Asp Val Val
            100                 105                 110         
Val Cys Asp Gln Val Ser Ala Cys Ile Pro Val Phe Arg Leu Ala Arg
        115                 120                 125             
Arg Arg Lys Lys Ile Leu Phe Tyr Cys His Phe Pro Asp Leu Leu Leu
    130                 135                 140                 
Thr Lys Arg Asp Ser Phe Leu Lys Arg Leu Tyr Arg Ala Pro Ile Asp
145                 150                 155                 160 
Trp Ile Glu Glu Tyr Thr Thr Gly Met Ala Asp Cys Ile Leu Val Asn
                165                 170                 175     
Ser Arg Phe Thr Ala Ala Val Phe Lys Glu Thr Phe Lys Ser Leu Ser
            180                 185                 190         
His Ile Asp Pro Asp Val Leu Tyr Pro Ser Leu Asn Val Thr Ser Phe
        195                 200                 205             
Asp Ser Val Val Pro Glu Lys Leu Asp Asp Leu Val Pro Lys Gly Lys
    210                 215                 220                 
Lys Phe Leu Leu Leu Ser Ile Asn Arg Tyr Glu Arg Lys Lys Asn Leu
225                 230                 235                 240 
Thr Leu Ala Leu Glu Ala Leu Val Gln Leu Arg Gly Arg Leu Thr Ser
                245                 250                 255     
Gln Asp Trp Glu Arg Val His Leu Ile Val Ala Gly Gly Tyr Asp Glu
            260                 265                 270         
Arg Val Leu Glu Asn Val Glu His Tyr Gln Glu Leu Lys Lys Met Val
        275                 280                 285             
Gln Gln Ser Asp Leu Gly Gln Tyr Val Thr Phe Leu Arg Ser Phe Ser
    290                 295                 300                 
Asp Lys Gln Lys Ile Ser Leu Leu His Ser Cys Thr Cys Val Leu Tyr
305                 310                 315                 320 
Thr Pro Ser Asn Glu His Phe Gly Ile Val Pro Leu Glu Ala Met Tyr
                325                 330                 335     
Met Gln Cys Pro Val Ile Ala Val Asn Ser Gly Gly Pro Leu Glu Ser
            340                 345                 350         
Ile Asp His Ser Val Thr Gly Phe Leu Cys Glu Pro Asp Pro Val His
        355                 360                 365             
Phe Ser Glu Ala Ile Glu Lys Phe Ile Arg Glu Pro Ser Leu Lys Ala
    370                 375                 380                 
Thr Met Gly Leu Ala Gly Arg Ala Arg Val Lys Glu Lys Phe Ser Pro
385                 390                 395                 400 
Glu Ala Phe Thr Glu Gln Leu Tyr Arg Tyr Val Thr Lys Leu Leu Val
                405                 410                 415     


<210> 7454
<211> 416
<212> PRT
<213> Homo sapiens

<400> 7454
Met Ala Glu Glu Gln Gly Arg Glu Arg Asp Ser Val Pro Lys Pro Ser
 1               5                  10                  15      
Val Leu Phe Leu His Pro Asp Leu Gly Val Gly Gly Ala Glu Arg Leu
            20                  25                  30          
Val Leu Asp Ala Ala Leu Ala Leu Gln Ala Arg Gly Cys Ser Val Lys
        35                  40                  45              
Ile Trp Thr Ala His Tyr Asp Pro Gly His Cys Phe Ala Glu Ser Arg
    50                  55                  60                  
Glu Leu Pro Val Arg Cys Ala Gly Asp Trp Leu Pro Arg Gly Leu Gly
65                  70                  75                  80  
Trp Gly Gly Arg Gly Ala Ala Val Cys Ala Tyr Val Arg Met Val Phe
                85                  90                  95      
Leu Ala Leu Tyr Val Leu Phe Leu Ala Asp Glu Glu Phe Asp Val Val
            100                 105                 110         
Val Cys Asp Gln Val Ser Ala Cys Ile Pro Val Phe Arg Leu Ala Arg
        115                 120                 125             
Arg Arg Lys Lys Ile Leu Phe Tyr Cys His Phe Pro Asp Leu Leu Leu
    130                 135                 140                 
Thr Lys Arg Asp Ser Phe Leu Lys Arg Leu Tyr Arg Ala Pro Ile Asp
145                 150                 155                 160 
Trp Ile Glu Glu Tyr Thr Thr Gly Met Ala Asp Cys Ile Leu Val Asn
                165                 170                 175     
Ser Gln Phe Thr Ala Ala Val Phe Lys Glu Thr Phe Lys Ser Leu Ser
            180                 185                 190         
His Ile Asp Pro Asp Val Leu Tyr Pro Ser Leu Asn Val Thr Ser Phe
        195                 200                 205             
Asp Ser Val Val Pro Glu Lys Leu Asp Asp Leu Val Pro Lys Gly Lys
    210                 215                 220                 
Lys Phe Leu Leu Leu Ser Ile Asn Arg Tyr Glu Arg Lys Lys Asn Leu
225                 230                 235                 240 
Thr Leu Ala Leu Glu Ala Leu Val Gln Leu Arg Gly Arg Leu Thr Ser
                245                 250                 255     
Gln Asp Trp Glu Arg Val His Leu Ile Val Ala Gly Gly Tyr Asp Glu
            260                 265                 270         
Arg Val Leu Glu Asn Val Glu His Tyr Gln Glu Leu Lys Lys Met Val
        275                 280                 285             
Gln Gln Ser Asp Leu Gly Gln Tyr Val Thr Phe Leu Arg Ser Phe Ser
    290                 295                 300                 
Asp Lys Gln Lys Ile Ser Leu Leu His Ser Cys Thr Cys Val Leu Tyr
305                 310                 315                 320 
Thr Pro Ser Asn Glu His Phe Gly Ile Val Pro Leu Glu Ala Met Tyr
                325                 330                 335     
Met Gln Cys Pro Val Ile Ala Val Asn Ser Gly Gly Pro Leu Glu Ser
            340                 345                 350         
Ile Asp His Ser Val Thr Gly Phe Leu Cys Glu Pro Asp Pro Val His
        355                 360                 365             
Phe Ser Glu Ala Ile Glu Lys Phe Ile Arg Glu Pro Ser Leu Lys Ala
    370                 375                 380                 
Thr Met Gly Leu Ala Gly Arg Ala Arg Val Lys Glu Lys Phe Ser Pro
385                 390                 395                 400 
Glu Ala Phe Thr Glu Gln Leu Tyr Arg Tyr Val Thr Lys Leu Leu Val
                405                 410                 415     


<210> 7455
<211> 323
<212> PRT
<213> Homo sapiens

<400> 7455
Met Pro Leu Leu Lys Leu Val His Gly Ser Pro Leu Val Phe Gly Glu
 1               5                  10                  15      
Lys Phe Lys Leu Phe Thr Leu Val Ser Ala Cys Ile Pro Val Phe Arg
            20                  25                  30          
Leu Ala Arg Arg Arg Lys Lys Ile Leu Phe Tyr Cys His Phe Pro Asp
        35                  40                  45              
Leu Leu Leu Thr Lys Arg Asp Ser Phe Leu Lys Arg Leu Tyr Arg Ala
    50                  55                  60                  
Pro Ile Asp Trp Ile Glu Glu Tyr Thr Thr Gly Met Ala Asp Cys Ile
65                  70                  75                  80  
Leu Val Asn Ser Gln Phe Thr Ala Ala Val Phe Lys Glu Thr Phe Lys
                85                  90                  95      
Ser Leu Ser His Ile Asp Pro Asp Val Leu Tyr Pro Ser Leu Asn Val
            100                 105                 110         
Thr Ser Phe Asp Ser Val Val Pro Glu Lys Leu Asp Asp Leu Val Pro
        115                 120                 125             
Lys Gly Lys Lys Phe Leu Leu Leu Ser Ile Asn Arg Tyr Glu Arg Lys
    130                 135                 140                 
Lys Asn Leu Thr Leu Ala Leu Glu Ala Leu Val Gln Leu Arg Gly Arg
145                 150                 155                 160 
Leu Thr Ser Gln Asp Trp Glu Arg Val His Leu Ile Val Ala Gly Gly
                165                 170                 175     
Tyr Asp Glu Arg Val Leu Glu Asn Val Glu His Tyr Gln Glu Leu Lys
            180                 185                 190         
Lys Met Val Gln Gln Ser Asp Leu Gly Gln Tyr Val Thr Phe Leu Arg
        195                 200                 205             
Ser Phe Ser Asp Lys Gln Lys Ile Ser Leu Leu His Ser Cys Thr Cys
    210                 215                 220                 
Val Leu Tyr Thr Pro Ser Asn Glu His Phe Gly Ile Val Pro Leu Glu
225                 230                 235                 240 
Ala Met Tyr Met Gln Cys Pro Val Ile Ala Val Asn Ser Gly Gly Pro
                245                 250                 255     
Leu Glu Ser Ile Asp His Ser Val Thr Gly Phe Leu Cys Glu Pro Asp
            260                 265                 270         
Pro Val His Phe Ser Glu Ala Ile Glu Lys Phe Ile Arg Glu Pro Ser
        275                 280                 285             
Leu Lys Ala Thr Met Gly Leu Ala Gly Arg Ala Arg Val Lys Glu Lys
    290                 295                 300                 
Phe Ser Pro Glu Ala Phe Thr Glu Gln Leu Tyr Arg Tyr Val Thr Lys
305                 310                 315                 320 
Leu Leu Val
            


<210> 7456
<211> 560
<212> PRT
<213> Homo sapiens

<400> 7456
Met Gly Gln Pro Ala Pro Tyr Ala Glu Gly Pro Ile Gln Gly Gly Asp
 1               5                  10                  15      
Ala Gly Glu Leu Cys Lys Cys Asp Phe Leu Val Ser Ile Ser Ile Pro
            20                  25                  30          
Gln Thr Arg Ser Asp Ile Pro Ala Gly Ala Arg Arg Ser Ser Met Gly
        35                  40                  45              
Pro Arg Ser Leu Asp Thr Cys Trp Gly Arg Gly Pro Glu Arg His Val
    50                  55                  60                  
His Arg Leu Glu Cys Asn Gly Val Ile Phe Thr His Arg Asn Leu Cys
65                  70                  75                  80  
Leu Pro Gly Gly Lys Thr Lys Thr Glu Asn Glu Glu Lys Thr Ala Gln
                85                  90                  95      
Leu Asn Ile Ser Lys Glu Ser Glu Ser His Arg Leu Ile Val Glu Gly
            100                 105                 110         
Leu Leu Met Asp Val Pro Gln His Pro Asp Phe Lys Asp Arg Leu Glu
        115                 120                 125             
Lys Ser Gln Leu His Asp Thr Gly Asn Lys Thr Lys Ile Gly Asp Cys
    130                 135                 140                 
Thr Asp Leu Thr Val Gln Asp His Glu Ser Ser Thr Thr Glu Arg Glu
145                 150                 155                 160 
Glu Ile Ala Arg Lys Leu Glu Glu Ser Ser Val Ser Thr His Leu Ile
                165                 170                 175     
Thr Lys Gln Gly Phe Ala Lys Glu Gln Val Phe Tyr Lys Cys Gly Glu
            180                 185                 190         
Cys Gly Ser Tyr Tyr Asn Pro His Ser Asp Phe His Leu His Gln Arg
        195                 200                 205             
Val His Thr Asn Glu Lys Pro Tyr Thr Cys Lys Glu Cys Gly Lys Thr
    210                 215                 220                 
Phe Arg Tyr Asn Ser Lys Leu Ser Arg His Gln Lys Ile His Thr Gly
225                 230                 235                 240 
Glu Lys Pro Tyr Ser Cys Glu Glu Cys Gly Gln Ala Phe Ser Gln Asn
                245                 250                 255     
Ser His Leu Leu Gln His Gln Lys Leu His Gly Gly Gln Arg Pro Tyr
            260                 265                 270         
Glu Cys Thr Asp Cys Gly Lys Thr Phe Ser Tyr Asn Ser Lys Leu Ile
        275                 280                 285             
Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Lys Glu
    290                 295                 300                 
Cys Gly Lys Ala Phe Ser Cys Ser Tyr Asp Cys Ile Ile His Glu Arg
305                 310                 315                 320 
Ile His Asn Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser
                325                 330                 335     
Leu Ser Ser Asn Ser Val Leu Ile Gln His Gln Arg Ile His Thr Gly
            340                 345                 350         
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe His Arg Ser
        355                 360                 365             
Ser Val Phe Leu Gln His Gln Arg Phe His Thr Gly Glu Gln Leu Tyr
    370                 375                 380                 
Lys Cys Asn Glu Cys Trp Lys Thr Phe Ser Cys Ser Ser Arg Phe Ile
385                 390                 395                 400 
Val His Gln Arg Ile His Asn Gly Glu Lys Pro Tyr Glu Cys Gln Glu
                405                 410                 415     
Cys Gly Lys Thr Phe Ser Gln Lys Ile Thr Leu Val Gln His Gln Arg
            420                 425                 430         
Val His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala
        435                 440                 445             
Phe Arg Trp Asn Ala Ser Phe Ile Gln His Gln Lys Trp His Thr Arg
    450                 455                 460                 
Lys Lys Leu Ile Asn Gly Thr Gly Leu Ser Ala Val Lys Pro Tyr Cys
465                 470                 475                 480 
Pro Cys Ala Ile Leu Ser Pro Leu Pro Pro Gln His Thr Cys Ser Ala
                485                 490                 495     
Leu Ala Pro Pro Gly Pro Pro Leu Ser Ser Ser His Ala Val Val Leu
            500                 505                 510         
Pro Pro Ser Val Pro Phe Phe Leu Leu Leu Pro Ser Ser Glu Lys Ala
        515                 520                 525             
Asn Pro Ser Pro Val Gln Ile Ala His Phe Phe Gln Asp Leu Ala Phe
    530                 535                 540                 
Pro Gly Lys Ser Ser Leu Gln Ser Pro Asn Pro Leu Ser His Ser Leu
545                 550                 555                 560 


<210> 7457
<211> 1722
<212> PRT
<213> Homo sapiens

<400> 7457
Met Ser Asp Pro Arg Gln Ser Gln Glu Glu Lys His Lys Leu Gly Arg
 1               5                  10                  15      
Ala Ser Ser Lys Phe Lys Asp Pro Pro Arg Ile Met Gln Ser Asp Asp
            20                  25                  30          
Tyr Phe Ala Arg Lys Phe Lys Ala Ile Asn Gly Asn Met Gly Pro Thr
        35                  40                  45              
Thr Ser Leu Asn Ala Ser Asn Ser Asn Glu Thr Gly Gly Gly Gly Pro
    50                  55                  60                  
Ala Asn Gly Thr Pro Ala Val Pro Lys Met Gly Val Arg Ala Arg Val
65                  70                  75                  80  
Ser Glu Trp Pro Pro Lys Lys Asp Cys Ser Lys Glu Leu Thr Cys Lys
                85                  90                  95      
Ala Leu Trp Glu Ser Arg Ser Gln Thr Ser Tyr Glu Ser Ile Thr Ser
            100                 105                 110         
Val Leu Gln Asn Gly Gln Ser Asp Gln Ser Glu Gly Gln Gln Asp Glu
        115                 120                 125             
Gln Leu Asp Leu Asp Phe Val Glu Ala Lys Tyr Thr Ile Gly Asp Ile
    130                 135                 140                 
Phe Val His Ser Pro Gln Arg Gly Leu His Pro Ile Arg Gln Arg Ser
145                 150                 155                 160 
Asn Ser Asp Val Thr Ile Ser Asp Ile Asp Ala Glu Asp Val Leu Asp
                165                 170                 175     
Gln Asn Ala Val Asn Pro Asn Thr Gly Ala Ala Leu His Arg Glu Tyr
            180                 185                 190         
Gly Ser Thr Ser Ser Ile Asp Arg Gln Gly Leu Ser Gly Glu Asn Phe
        195                 200                 205             
Phe Ala Met Leu Arg Gly Tyr Arg Val Glu Asn Tyr Asp His Lys Ala
    210                 215                 220                 
Met Val Pro Phe Gly Phe Pro Glu Phe Phe Arg Cys Asp Pro Ala Ile
225                 230                 235                 240 
Ser Pro Ser Leu His Ala Ala Ala Gln Ile Ser Arg Gly Glu Phe Val
                245                 250                 255     
Arg Ile Ser Gly Leu Asp Tyr Val Asp Ser Ala Leu Leu Met Gly Arg
            260                 265                 270         
Asp Arg Asp Lys Pro Phe Lys Arg Arg Leu Lys Ser Glu Ser Val Glu
        275                 280                 285             
Thr Ser Leu Phe Arg Lys Leu Arg Thr Val Lys Ser Glu His Glu Thr
    290                 295                 300                 
Phe Lys Phe Thr Ser Glu Leu Glu Glu Ser Arg Leu Glu Arg Gly Ile
305                 310                 315                 320 
Arg Pro Trp Asn Cys Gln Arg Cys Phe Ala His Tyr Asp Val Gln Ser
                325                 330                 335     
Ile Leu Phe Asn Ile Asn Glu Ala Met Ala Thr Arg Ala Asn Val Gly
            340                 345                 350         
Lys Arg Lys Asn Ile Thr Thr Gly Ala Ser Ala Ala Ser Gln Thr Gln
        355                 360                 365             
Met Pro Thr Gly Gln Thr Gly Asn Cys Glu Ser Pro Leu Gly Ser Lys
    370                 375                 380                 
Glu Asp Leu Asn Ser Lys Glu Asn Leu Asp Ala Asp Glu Gly Asp Gly
385                 390                 395                 400 
Lys Ser Asn Asp Leu Val Leu Ser Cys Pro Tyr Phe Arg Asn Glu Thr
                405                 410                 415     
Gly Gly Glu Gly Asp Arg Arg Ile Ala Leu Ser Arg Ala Asn Ser Ser
            420                 425                 430         
Ser Phe Ser Ser Gly Glu Ser Cys Ser Phe Glu Ser Ser Leu Ser Ser
        435                 440                 445             
His Cys Thr Asn Ala Gly Val Ser Val Leu Glu Val Pro Arg Glu Asn
    450                 455                 460                 
Gln Pro Ile His Arg Glu Lys Val Lys Arg Tyr Ile Ile Glu His Ile
465                 470                 475                 480 
Asp Leu Gly Ala Tyr Tyr Tyr Arg Lys Phe Phe Tyr Gly Lys Glu His
                485                 490                 495     
Gln Asn Tyr Phe Gly Ile Asp Glu Asn Leu Gly Pro Val Ala Val Ser
            500                 505                 510         
Ile Arg Arg Glu Lys Val Glu Asp Ala Lys Glu Lys Glu Gly Ser Gln
        515                 520                 525             
Phe Asn Tyr Arg Val Ala Phe Arg Thr Ser Glu Leu Thr Thr Leu Arg
    530                 535                 540                 
Gly Ala Ile Leu Glu Asp Ala Ile Pro Ser Thr Ala Arg His Gly Thr
545                 550                 555                 560 
Ala Arg Gly Leu Pro Leu Lys Glu Val Leu Glu Tyr Val Ile Pro Glu
                565                 570                 575     
Leu Ser Ile Gln Cys Leu Arg Gln Ala Ser Asn Ser Pro Lys Val Ser
            580                 585                 590         
Glu Gln Leu Leu Lys Leu Asp Glu Gln Gly Leu Ser Phe Gln His Lys
        595                 600                 605             
Ile Gly Ile Leu Tyr Cys Lys Ala Gly Gln Ser Thr Glu Glu Glu Met
    610                 615                 620                 
Tyr Asn Asn Glu Thr Ala Gly Pro Ala Phe Glu Glu Phe Leu Asp Leu
625                 630                 635                 640 
Leu Gly Gln Arg Val Arg Leu Lys Gly Phe Ser Lys Tyr Arg Ala Gln
                645                 650                 655     
Leu Asp Asn Lys Thr Asp Ser Thr Gly Thr His Ser Leu Tyr Thr Thr
            660                 665                 670         
Tyr Lys Asp Tyr Glu Leu Met Phe His Val Ser Thr Leu Leu Pro Tyr
        675                 680                 685             
Met Pro Asn Asn Arg Gln Gln Leu Leu Arg Lys Arg His Ile Gly Asn
    690                 695                 700                 
Asp Ile Val Thr Ile Val Phe Gln Glu Pro Gly Ala Leu Pro Phe Thr
705                 710                 715                 720 
Pro Lys Ser Ile Arg Ser His Phe Gln His Val Phe Val Ile Val Lys
                725                 730                 735     
Val His Asn Pro Cys Thr Glu Asn Val Cys Tyr Ser Val Gly Val Ser
            740                 745                 750         
Arg Ser Lys Asp Val Pro Pro Phe Gly Pro Pro Ile Pro Lys Gly Val
        755                 760                 765             
Thr Phe Pro Lys Ser Ala Val Phe Arg Asp Phe Leu Leu Ala Lys Val
    770                 775                 780                 
Ile Asn Ala Glu Asn Ala Ala His Lys Ser Glu Lys Phe Arg Ala Met
785                 790                 795                 800 
Ala Thr Arg Thr Arg Gln Glu Tyr Leu Lys Asp Leu Ala Glu Asn Phe
                805                 810                 815     
Val Thr Thr Ala Thr Val Asp Thr Ser Val Lys Phe Ser Phe Ile Thr
            820                 825                 830         
Leu Gly Ala Lys Lys Lys Glu Lys Val Lys Pro Arg Lys Asp Ala His
        835                 840                 845             
Leu Phe Ser Ile Gly Ala Ile Met Trp His Val Ile Ala Arg Asp Phe
    850                 855                 860                 
Gly Gln Ser Ala Asp Ile Glu Cys Leu Leu Gly Ile Ser Asn Glu Phe
865                 870                 875                 880 
Ile Met Leu Ile Glu Lys Asp Ser Lys Asn Val Val Phe Asn Cys Ser
                885                 890                 895     
Cys Arg Asp Val Ile Gly Trp Thr Ser Gly Leu Val Ser Ile Lys Val
            900                 905                 910         
Phe Tyr Glu Arg Gly Glu Cys Val Leu Leu Ser Ser Val Asp Asn Cys
        915                 920                 925             
Ala Glu Asp Ile Arg Glu Ile Val Gln Arg Leu Val Ile Val Thr Arg
    930                 935                 940                 
Gly Cys Glu Thr Val Glu Met Thr Leu Arg Arg Asn Gly Leu Gly Gln
945                 950                 955                 960 
Leu Gly Phe His Val Asn Phe Glu Gly Ile Val Ala Asp Val Glu Pro
                965                 970                 975     
Phe Gly Phe Ala Trp Lys Ala Gly Leu Arg Gln Gly Ser Arg Leu Val
            980                 985                 990         
Glu Ile Cys Lys Val Ala Val Ala Thr Leu Thr His Glu Gln Met Ile
        995                 1000                1005            
Asp Leu Leu Arg Thr Ser Val Thr Val Lys Val Val Ile Ile Gln Pro
    1010                1015                1020                
His Asp Asp Gly Ser Pro Arg Arg Gly Cys Ser Glu Leu Cys Arg Ile
1025                1030                1035                1040
Pro Met Val Glu Tyr Lys Leu Asp Ser Glu Gly Thr Pro Cys Glu Tyr
                1045                1050                1055    
Lys Thr Pro Phe Arg Arg Asn Thr Thr Trp His Arg Val Pro Thr Pro
            1060                1065                1070        
Ala Leu Gln Pro Leu Ser Arg Ala Ser Pro Ile Pro Gly Thr Pro Asp
        1075                1080                1085            
Arg Leu Pro Cys Gln Gln Leu Leu Gln Gln Ala Gln Ala Ala Ile Pro
    1090                1095                1100                
Arg Ser Thr Ser Phe Asp Arg Lys Leu Pro Asp Gly Thr Arg Ser Ser
1105                1110                1115                1120
Pro Ser Asn Gln Ser Ser Ser Ser Asp Pro Gly Pro Gly Gly Ser Gly
                1125                1130                1135    
Pro Trp Arg Pro Gln Val Gly Tyr Asp Gly Cys Gln Ser Pro Leu Leu
            1140                1145                1150        
Leu Glu His Gln Gly Ser Gly Pro Leu Glu Cys Asp Gly Ala Arg Glu
        1155                1160                1165            
Arg Glu Asp Thr Met Glu Ala Ser Arg His Pro Glu Thr Lys Trp His
    1170                1175                1180                
Gly Pro Pro Ser Lys Val Leu Gly Ser Tyr Lys Glu Arg Ala Leu Gln
1185                1190                1195                1200
Lys Asp Gly Ser Cys Lys Asp Ser Pro Asn Lys Leu Ser His Ile Gly
                1205                1210                1215    
Asp Lys Ser Cys Ser Ser His Ser Ser Ser Asn Thr Leu Ser Ser Asn
            1220                1225                1230        
Thr Ser Ser Asn Ser Asp Asp Lys His Phe Gly Ser Gly Asp Leu Met
        1235                1240                1245            
Asp Pro Glu Leu Leu Gly Leu Thr Tyr Ile Lys Gly Ala Ser Thr Asp
    1250                1255                1260                
Ser Gly Ile Asp Thr Ala Pro Cys Met Pro Ala Thr Ile Leu Gly Pro
1265                1270                1275                1280
Val His Leu Ala Gly Ser Arg Ser Leu Ile His Ser Arg Ala Glu Gln
                1285                1290                1295    
Trp Ala Asp Ala Ala Asp Val Ser Gly Pro Asp Asp Glu Pro Ala Lys
            1300                1305                1310        
Leu Tyr Ser Val His Gly Tyr Ala Ser Thr Ile Ser Ala Gly Ser Ala
        1315                1320                1325            
Ala Glu Gly Ser Met Gly Asp Leu Ser Glu Ile Ser Ser His Ser Ser
    1330                1335                1340                
Gly Ser His His Ser Gly Ser Pro Ser Ala His Cys Ser Lys Ser Ser
1345                1350                1355                1360
Gly Ser Leu Asp Ser Ser Lys Val Tyr Ile Val Ser His Ser Ser Gly
                1365                1370                1375    
Gln Gln Val Pro Gly Ser Met Ser Lys Pro Tyr His Arg Gln Gly Ala
            1380                1385                1390        
Val Asn Lys Tyr Val Ile Gly Trp Lys Lys Ser Glu Gly Ser Pro Pro
        1395                1400                1405            
Pro Glu Glu Pro Glu Val Thr Glu Cys Pro Gly Met Tyr Ser Glu Met
    1410                1415                1420                
Asp Val Met Ser Thr Ala Thr Gln His Gln Thr Val Val Gly Asp Ala
1425                1430                1435                1440
Val Ala Glu Thr Gln His Val Leu Ser Lys Glu Asp Phe Leu Lys Leu
                1445                1450                1455    
Met Leu Pro Asp Ser Pro Leu Val Glu Glu Gly Arg Arg Lys Phe Ser
            1460                1465                1470        
Phe Tyr Gly Asn Leu Ser Pro Arg Arg Ser Leu Tyr Arg Thr Leu Ser
        1475                1480                1485            
Asp Glu Ser Ile Cys Ser Asn Arg Arg Gly Ser Ser Phe Gly Ser Ser
    1490                1495                1500                
Arg Ser Ser Val Leu Asp Gln Ala Leu Pro Asn Asp Ile Leu Phe Ser
1505                1510                1515                1520
Thr Thr Pro Pro Tyr His Ser Thr Leu Pro Pro Arg Ala His Pro Ala
                1525                1530                1535    
Pro Ser Met Gly Ser Leu Arg Asn Glu Phe Trp Phe Ser Asp Gly Ser
            1540                1545                1550        
Leu Ser Asp Lys Ser Lys Cys Ala Asp Pro Gly Leu Met Pro Leu Pro
        1555                1560                1565            
Asp Thr Ala Thr Gly Leu Asp Trp Thr His Leu Val Asp Ala Ala Arg
    1570                1575                1580                
Ala Phe Glu Gly Leu Asp Ser Asp Glu Glu Leu Gly Leu Leu Cys His
1585                1590                1595                1600
His Thr Ser Tyr Leu Asp Gln Arg Val Ala Ser Phe Cys Thr Leu Thr
                1605                1610                1615    
Asp Met Gln His Gly Gln Asp Leu Glu Gly Ala Gln Glu Leu Pro Leu
            1620                1625                1630        
Cys Val Asp Pro Gly Ser Gly Lys Glu Phe Met Asp Thr Thr Gly Glu
        1635                1640                1645            
Arg Ser Pro Ser Pro Leu Thr Gly Lys Val Asn Gln Leu Glu Leu Ile
    1650                1655                1660                
Leu Arg Gln Leu Gln Thr Asp Leu Arg Lys Glu Lys Gln Asp Lys Ala
1665                1670                1675                1680
Val Leu Gln Ala Glu Val Gln His Leu Arg Gln Asp Asn Met Arg Leu
                1685                1690                1695    
Gln Glu Glu Ser Gln Thr Ala Thr Ala Gln Leu Arg Lys Phe Thr Glu
            1700                1705                1710        
Trp Phe Phe Thr Thr Ile Asp Lys Lys Ser
        1715                1720        


<210> 7458
<211> 778
<212> PRT
<213> Homo sapiens

<400> 7458
Met Ser Pro Cys Phe Ser Phe Ile Gly Cys Lys Leu Cys Ser Ile Val
 1               5                  10                  15      
Thr Arg Gly Cys Glu Thr Val Glu Met Thr Leu Arg Arg Asn Gly Leu
            20                  25                  30          
Gly Gln Leu Gly Phe His Val Asn Phe Glu Gly Ile Val Ala Asp Val
        35                  40                  45              
Glu Pro Phe Gly Phe Ala Trp Lys Ala Gly Leu Arg Gln Gly Ser Arg
    50                  55                  60                  
Leu Val Glu Ile Cys Lys Val Ala Val Ala Thr Leu Thr His Glu Gln
65                  70                  75                  80  
Met Ile Asp Leu Leu Arg Thr Ser Val Thr Val Lys Val Val Ile Ile
                85                  90                  95      
Gln Pro His Asp Asp Gly Ser Pro Arg Arg Gly Cys Ser Glu Leu Cys
            100                 105                 110         
Arg Ile Pro Met Val Glu Tyr Lys Leu Asp Ser Glu Gly Thr Pro Cys
        115                 120                 125             
Glu Tyr Lys Thr Pro Phe Arg Arg Asn Thr Thr Trp His Arg Val Pro
    130                 135                 140                 
Thr Pro Ala Leu Gln Pro Leu Ser Arg Ala Ser Pro Ile Pro Gly Thr
145                 150                 155                 160 
Pro Asp Arg Leu Pro Cys Gln Gln Leu Leu Gln Gln Ala Gln Ala Ala
                165                 170                 175     
Ile Pro Arg Ser Thr Ser Phe Asp Arg Lys Leu Pro Asp Gly Thr Arg
            180                 185                 190         
Ser Ser Pro Ser Asn Gln Ser Ser Ser Ser Asp Pro Gly Pro Gly Gly
        195                 200                 205             
Ser Gly Pro Trp Arg Pro Gln Val Gly Tyr Asp Gly Cys Gln Ser Pro
    210                 215                 220                 
Leu Leu Leu Glu His Gln Gly Ser Gly Pro Leu Glu Cys Asp Gly Ala
225                 230                 235                 240 
Arg Glu Arg Glu Asp Thr Met Glu Ala Ser Arg His Pro Glu Thr Lys
                245                 250                 255     
Trp His Gly Pro Pro Ser Lys Val Leu Gly Ser Tyr Lys Glu Arg Ala
            260                 265                 270         
Leu Gln Lys Asp Gly Ser Cys Lys Asp Ser Pro Asn Lys Leu Ser His
        275                 280                 285             
Ile Gly Asp Lys Ser Cys Ser Ser His Ser Ser Ser Asn Thr Leu Ser
    290                 295                 300                 
Ser Asn Thr Ser Ser Asn Ser Asp Asp Lys His Phe Gly Ser Gly Asp
305                 310                 315                 320 
Leu Met Asp Pro Glu Leu Leu Gly Leu Thr Tyr Ile Lys Gly Ala Ser
                325                 330                 335     
Thr Asp Ser Gly Ile Asp Thr Ala Pro Cys Met Pro Ala Thr Ile Leu
            340                 345                 350         
Gly Pro Val His Leu Ala Gly Ser Arg Ser Leu Ile His Ser Arg Ala
        355                 360                 365             
Glu Gln Trp Ala Asp Ala Ala Asp Val Ser Gly Pro Asp Asp Glu Pro
    370                 375                 380                 
Ala Lys Leu Tyr Ser Val His Gly Tyr Ala Ser Thr Ile Ser Ala Gly
385                 390                 395                 400 
Ser Ala Ala Glu Gly Ser Met Gly Asp Leu Ser Glu Ile Ser Ser His
                405                 410                 415     
Ser Ser Gly Ser His His Ser Gly Ser Pro Ser Ala His Cys Ser Lys
            420                 425                 430         
Ser Ser Gly Ser Leu Asp Ser Ser Lys Val Tyr Ile Val Ser His Ser
        435                 440                 445             
Ser Gly Gln Gln Val Pro Gly Ser Met Ser Lys Pro Tyr His Arg Gln
    450                 455                 460                 
Gly Ala Val Asn Lys Tyr Val Ile Gly Trp Lys Lys Ser Glu Gly Ser
465                 470                 475                 480 
Pro Pro Pro Glu Glu Pro Glu Val Thr Glu Cys Pro Gly Met Tyr Ser
                485                 490                 495     
Glu Met Asp Val Met Ser Thr Ala Thr Gln His Gln Thr Val Val Gly
            500                 505                 510         
Asp Ala Val Ala Glu Thr Gln His Val Leu Ser Lys Glu Asp Phe Leu
        515                 520                 525             
Lys Leu Met Leu Pro Asp Ser Pro Leu Val Glu Glu Gly Arg Arg Lys
    530                 535                 540                 
Phe Ser Phe Tyr Gly Asn Leu Ser Pro Arg Arg Ser Leu Tyr Arg Thr
545                 550                 555                 560 
Leu Ser Asp Glu Ser Ile Cys Ser Asn Arg Arg Gly Ser Ser Phe Gly
                565                 570                 575     
Ser Ser Arg Ser Ser Val Leu Asp Gln Ala Leu Pro Asn Asp Ile Leu
            580                 585                 590         
Phe Ser Thr Thr Pro Pro Tyr His Ser Thr Leu Pro Pro Arg Val His
        595                 600                 605             
Pro Ala Pro Ser Met Gly Ser Leu Arg Asn Glu Phe Trp Phe Ser Asp
    610                 615                 620                 
Gly Ser Leu Ser Asp Lys Ser Lys Cys Ala Asp Pro Gly Leu Met Pro
625                 630                 635                 640 
Leu Pro Asp Thr Ala Thr Gly Leu Asp Trp Thr His Leu Val Asp Ala
                645                 650                 655     
Ala Arg Ala Phe Glu Asp Gln Arg Val Ala Ser Phe Cys Thr Leu Thr
            660                 665                 670         
Asp Met Gln His Gly Gln Asp Leu Glu Gly Ala Gln Glu Leu Pro Leu
        675                 680                 685             
Cys Val Asp Pro Gly Ser Gly Lys Glu Phe Met Asp Thr Thr Gly Glu
    690                 695                 700                 
Arg Ser Pro Ser Pro Leu Thr Gly Lys Val Asn Gln Leu Glu Leu Ile
705                 710                 715                 720 
Leu Arg Gln Leu Gln Thr Asp Leu Arg Lys Glu Lys Gln Asp Lys Ala
                725                 730                 735     
Val Leu Gln Ala Glu Val Gln His Leu Arg Gln Asp Asn Met Arg Leu
            740                 745                 750         
Gln Glu Glu Ser Gln Thr Ala Thr Ala Gln Leu Arg Lys Phe Thr Glu
        755                 760                 765             
Trp Phe Phe Thr Thr Ile Asp Lys Lys Ser
    770                 775             


<210> 7459
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7459
Ser Pro Arg Arg Met Cys Ser Leu Pro Arg Gly Phe Glu Pro Gln Ala
 1               5                  10                  15      
Pro Glu Asp Leu Ala Gln Arg Ser Leu Val Glu Leu Arg Glu Met Leu
            20                  25                  30          
Lys Arg Gln Glu Arg Leu Leu Arg Asn Glu Lys Phe Ile Cys Lys Leu
        35                  40                  45              
Pro Asp Lys Gly Lys Lys Ile Phe Asp Ser Phe Ala Lys Leu Lys Ala
    50                  55                  60                  
Ala Ile Ala Glu Cys Glu Glu Val Arg Arg Lys Ser Glu Leu Phe Asn
65                  70                  75                  80  
Pro Val Ser Leu Asp Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu Val
                85                  90                  95      
Asp Val Gly Thr Asp Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr
            100                 105                 110         
Ser Ser Leu Val Pro Gly Cys Ser Ser Val Asp Asn Ile Lys Ser Ser
        115                 120                 125             
Gln Thr Ser Gln Asn Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp
    130                 135                 140                 
Glu Glu Thr Ser Glu Val Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser
145                 150                 155                 160 
Ser Asn Arg Asp Arg Val Pro Pro Ser Ser Glu Ala Ser Glu His His
                165                 170                 175     
Pro Arg His Arg Val Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe
            180                 185                 190         
Asp Asn Leu Phe Ile Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln
        195                 200                 205             
Gly Glu Gln Gln Ser Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly
    210                 215                 220                 
Leu Ser Ser Gly Thr Glu Lys Lys Pro His Tyr Met Glu Val Leu Glu
225                 230                 235                 240 
Met Arg Ala Lys Asn Pro Val Pro Gln Leu Arg Lys Phe Lys Thr Asn
                245                 250                 255     
Val Leu Pro Phe Arg Gln Asn Asp Ser Ser Ser His Cys Gln Lys Ser
            260                 265                 270         
Gly Ser Pro Ile Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln His
        275                 280                 285             
Leu Asp Asp Ile Thr Ala Ala Arg Leu Leu Pro Leu His His Met Pro
    290                 295                 300                 
Thr Gln Leu Leu Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln
305                 310                 315                 320 
Lys Gln Asn Tyr Glu Glu Met Gln Ala Lys Leu Ala Ala Gln Lys Leu
                325                 330                 335     
Ala Glu Arg Leu Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu
            340                 345                 350         
Ser Ser Gly Arg Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp Trp Ser
        355                 360                 365             
Ser Asp Glu Phe
    370         


<210> 7460
<211> 1982
<212> PRT
<213> Homo sapiens

<400> 7460
Met Ile Leu Leu Asp Asp Tyr Ile His Leu Ile Leu Gly Glu Glu Thr
 1               5                  10                  15      
Glu Gly His Thr Val Ser Gly Ser Leu Asp Arg Thr Gly Arg Gly Ala
            20                  25                  30          
Ala Gln Met Ala Cys Pro Ala Leu Gly Leu Glu Ala Leu Gln Pro Leu
        35                  40                  45              
Gln Pro Glu Pro Pro Pro Glu Pro Ala Phe Ser Glu Ala Gln Lys Trp
    50                  55                  60                  
Ile Glu Val Gly Ala Gly Gly Trp Arg Ala Ala Leu His Trp Arg Pro
65                  70                  75                  80  
Glu Pro Arg Thr Arg Ala Arg Ser Asp Arg Arg Ser Ser Leu Ala Ser
                85                  90                  95      
Pro Gln Pro Pro Pro Leu Ser Phe Ala Ser Cys Ser Arg Arg Cys Gln
            100                 105                 110         
Gly Lys Arg Ser Ala Ser Lys Ala Leu Gln Arg Arg Arg Lys Arg Glu
        115                 120                 125             
Pro Pro Glu Thr Ser Pro Val Leu Ala Phe Arg Gly Ile Leu Leu Leu
    130                 135                 140                 
Val Pro His Phe Ala Pro Cys Pro Pro Thr Pro His Pro Ser Gly Ala
145                 150                 155                 160 
Glu Leu Ala Val Ser Ser Arg Arg Arg Ile Pro Thr Gly Ala Ser Cys
                165                 170                 175     
Cys Ile Pro Gly Thr Gly Ser Gly Cys Gln Thr Leu Ser Glu Glu Thr
            180                 185                 190         
Asp Val Leu Arg Leu Gly Phe Gly Tyr Asp Leu Glu Gln Gln Val Thr
        195                 200                 205             
Gly Arg Ser Phe Gly Asp Lys Asp Phe Arg Thr Gly Leu Glu Asn Gly
    210                 215                 220                 
Ile Leu Leu Cys Asp Gln Trp Cys Phe Pro Leu Val Gly Ala Thr Pro
225                 230                 235                 240 
Tyr Ser Pro Ser Asp Ser Gln Met Leu Pro Gly Asn Gly Ser Met Gln
                245                 250                 255     
Ile Leu Phe Met Ala Ile Cys Ser Leu Arg Ile Glu Lys Cys Lys Ala
            260                 265                 270         
Lys Phe Gln Leu Leu Asn Ala Ile Lys Pro Gly Leu Val Lys Lys Ile
        275                 280                 285             
Asn Arg Leu Pro Thr Pro Ile Ala Gly Leu Asp Asn Ile Ile Leu Phe
    290                 295                 300                 
Leu Arg Gly Cys Lys Glu Leu Gly Leu Lys Glu Ser Gln Leu Phe Asp
305                 310                 315                 320 
Pro Ser Asp Leu Gln Asp Thr Ser Asn Arg Val Thr Val Lys Ser Leu
                325                 330                 335     
Asp Tyr Ser Arg Lys Leu Lys Asn Val Leu Val Thr Ile Tyr Trp Leu
            340                 345                 350         
Gly Lys Ala Ala Asn Ser Cys Thr Ser Tyr Ser Gly Thr Thr Leu Asn
        355                 360                 365             
Leu Lys Glu Phe Glu Gly Leu Leu Ala Gln Met Arg Lys Asp Thr Asp
    370                 375                 380                 
Asp Ile Glu Ser Pro Lys Arg Ser Ile Arg Asp Ser Gly Tyr Ile Asp
385                 390                 395                 400 
Cys Trp Asp Ser Glu Arg Ser Asp Ser Leu Ser Pro Pro Arg His Gly
                405                 410                 415     
Arg Asp Asp Ser Phe Asp Ser Leu Asp Ser Phe Gly Ser Arg Ser Arg
            420                 425                 430         
Gln Thr Pro Ser Pro Asp Val Val Leu Arg Gly Ser Ser Asp Gly Arg
        435                 440                 445             
Gly Ser Asp Ser Glu Ser Asp Leu Pro His Arg Lys Leu Pro Asp Val
    450                 455                 460                 
Lys Lys Asp Asp Met Ser Ala Arg Arg Thr Ser His Gly Glu Pro Lys
465                 470                 475                 480 
Ser Ala Val Pro Phe Asn Gln Tyr Leu Pro Asn Lys Ser Asn Gln Thr
                485                 490                 495     
Ala Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Ala Glu Arg Glu Glu
            500                 505                 510         
Tyr Arg Lys Ser Trp Ser Thr Ala Thr Ser Pro Leu Gly Gly Glu Arg
        515                 520                 525             
Pro Phe Ser Phe Pro Glu Thr Ile Glu Glu Glu Gly Ser Glu Val Gly
    530                 535                 540                 
Ser Ala Gly Glu Asp Asn Pro Ala Gly Gln Met Asn Pro Gly Trp Lys
545                 550                 555                 560 
Pro Ser Asp Gly Gly Cys Glu Leu Pro Asp Gly Ser Gly Lys Glu His
                565                 570                 575     
Pro Ser Ser Asp Gly Ala Val Val Ala Pro Ala Pro Lys Ser Glu Glu
            580                 585                 590         
Lys Asp Ala Ala Glu Ile Gln Lys Arg Lys Arg Leu Glu Gln Ala Gly
        595                 600                 605             
Ile Lys Val Met Pro Ala Ala Gln Arg Phe Ala Ser Gln Lys Gln Leu
    610                 615                 620                 
Ser Glu Glu Lys Glu Ala Ile Arg Asp Ile Val Leu Arg Lys Glu Asn
625                 630                 635                 640 
Ser Phe Leu Thr His Gln His Gly Asn Asp Ser Glu Ala Glu Gly Glu
                645                 650                 655     
Val Val Cys Arg Leu Pro Asp Leu Glu Lys Asp Asp Phe Ala Ala Arg
            660                 665                 670         
Arg Ala Arg Met Asn Gln Thr Lys Pro Met Val Pro Leu Asn Gln Leu
        675                 680                 685             
Leu Tyr Gly Pro Tyr Pro Lys Lys Gly Ala Glu Lys Ser Asp Gly Ser
    690                 695                 700                 
Lys Gln Leu Ser Lys Gly Ile Ser Lys Lys Arg Ser Leu Glu Tyr Lys
705                 710                 715                 720 
Arg Asn Gln Gly His Thr Glu Glu Val Lys Leu Ile Val Thr Cys Asn
                725                 730                 735     
Met Arg Ala Gln Glu Ser Glu Pro Val Glu Gly Gly Leu Arg Lys Val
            740                 745                 750         
Pro Asp Leu His Lys Asp Asp Leu Ala Gln Gln Arg Ile Gln Gly Ser
        755                 760                 765             
Leu Ala Pro His Arg Glu Pro Pro Ser Phe Ile Thr Leu Ser Asn Ile
    770                 775                 780                 
Thr Glu Ala Asp Leu Glu Thr Trp Glu Arg Leu Lys Val Ser Glu Lys
785                 790                 795                 800 
Ala Arg Asp Gly Asp Val Gln His Ile Cys Ala Ser Glu Pro Ser Pro
                805                 810                 815     
Glu Ile Lys Ala Glu Thr Ala Ile Arg Asp Asp Phe Ala Asn Arg Lys
            820                 825                 830         
Ala Arg Ala Ser Lys Lys Ala Ser Ser Pro Arg Gln Lys Phe Val His
        835                 840                 845             
Phe Gly Pro Val Thr Glu Leu Asp Gln Gln Lys Trp Lys Arg Leu Ser
    850                 855                 860                 
Ile Gly Lys Ala Gly Pro Arg Glu Asp Glu Glu Glu Val Ile Cys His
865                 870                 875                 880 
Gly Ser Lys Ile Gln Met Asp Ser Val Ser Pro Val Ser Ala Ala Thr
                885                 890                 895     
Ser Ser Leu Lys Gly His Gln Ile Phe Asn Arg Gln Asn Asp Cys Arg
            900                 905                 910         
Thr Met Asn Cys Gly Arg Gly Asp Tyr Cys Arg Arg Ala Ser Trp Leu
        915                 920                 925             
Ala Pro Val Pro Glu Ser Gln Glu Glu Trp Val Cys Ser Leu Gly Glu
    930                 935                 940                 
Cys Pro Arg Gly Thr Glu Glu Gly Val Lys Leu Ser Ser Leu Ala Leu
945                 950                 955                 960 
Val Thr Ser Lys Gln Leu Pro Gln Asp Gly Lys Glu Glu Thr Glu Ser
                965                 970                 975     
Ala Pro Arg Asp Ser Glu Arg Leu Ser Lys Ala Glu Arg Ser Glu Asp
            980                 985                 990         
Ser Ser Gln Pro Leu Val Cys Pro Leu Ala Ser Glu Cys Glu Ala Ser
        995                 1000                1005            
Gly Thr Glu Glu Lys Leu Glu Lys Met Thr Ala Pro Ala Trp Ser Gly
    1010                1015                1020                
Ser Gly Leu Lys Gly Gln Arg Lys Leu Asp Asp Ser Arg Lys Asp Asp
1025                1030                1035                1040
Met Met Ala Arg Arg Thr Gly Met Ser Leu Arg His Thr Gly Ser Asn
                1045                1050                1055    
Pro Asn Gln Phe Leu Pro Val Pro Phe Ala Lys Gln Gln Asp Val Glu
            1060                1065                1070        
Glu Ser Ser Lys Gly Leu Pro Met Lys Asp Gln Arg Tyr Gly Pro Arg
        1075                1080                1085            
Thr Pro Val Ser Asp Asp Ala Glu Gln Leu Pro Ala Arg Glu Pro Phe
    1090                1095                1100                
Ala Phe Gly Asp Ala Ala Ala Val His Cys Leu Ala Met Gly Val Thr
1105                1110                1115                1120
Ile Leu Asp Ile Ile Asp Asp Val Trp Asn Ser Leu Val Ser Lys Ser
                1125                1130                1135    
Thr Ser Met Phe Asp Met Arg Cys Glu Glu Glu Ala Ala Val Gln Pro
            1140                1145                1150        
His Ser Arg Ala Arg Gln Glu Gln Leu Gln Leu Ile Asn Asn Gln Leu
        1155                1160                1165            
Arg Glu Glu Asp Asp Lys Trp Gln Asp Val Ser Cys Gly Gln Gly Ala
    1170                1175                1180                
Arg Ala Ala Gly Arg Leu Leu Ala Ala Glu Asn Pro Ala Gly Trp Val
1185                1190                1195                1200
Asp Val Asp Leu Lys Ala Met Arg Gly Lys Gly Ala Pro Arg Gly Phe
                1205                1210                1215    
Gln Lys Asp Leu Ala Arg Trp Lys Ser Arg Arg Arg Ser Val Ser Gln
            1220                1225                1230        
Asp Leu Ile Lys Lys Glu Glu Glu Arg Lys Lys Met Glu Lys Leu Leu
        1235                1240                1245            
Ala Gly Glu Asp Gly Thr Ser Glu Arg Arg Lys Ser Ile Lys Thr Tyr
    1250                1255                1260                
Arg Glu Ile Val Gln Glu Lys Glu Arg Arg Glu Arg Glu Leu His Glu
1265                1270                1275                1280
Ala Tyr Lys Asn Ala Arg Ser Gln Glu Glu Ala Glu Gly Ile Leu Gln
                1285                1290                1295    
Gln Tyr Ile Glu Arg Phe Thr Ile Ser Glu Ala Val Leu Glu Arg Leu
            1300                1305                1310        
Glu Met Pro Lys Ile Leu Glu Arg Ser His Ser Thr Glu Pro Asn Leu
        1315                1320                1325            
Ser Ser Phe Leu Asn Asp Pro Asn Pro Met Lys Tyr Leu Arg Gln Gln
    1330                1335                1340                
Ser Leu Pro Pro Pro Lys Phe Thr Ala Thr Val Glu Thr Thr Ile Ala
1345                1350                1355                1360
Arg Ala Ser Val Leu Asp Thr Ser Met Ser Ala Gly Ser Gly Ser Pro
                1365                1370                1375    
Ser Lys Thr Val Thr Pro Lys Ala Val Pro Met Leu Thr Pro Lys Pro
            1380                1385                1390        
Tyr Ser Gln Pro Lys Asn Ser Gln Asp Val Leu Lys Thr Phe Lys Val
        1395                1400                1405            
Asp Gly Lys Val Ser Val Asn Gly Glu Thr Val His Arg Glu Glu Glu
    1410                1415                1420                
Lys Glu Arg Glu Cys Pro Thr Val Ala Pro Ala His Ser Leu Thr Lys
1425                1430                1435                1440
Ser Gln Met Phe Glu Gly Val Ala Arg Val His Gly Ser Pro Leu Glu
                1445                1450                1455    
Leu Lys Gln Asp Asn Gly Ser Ile Glu Ile Asn Ile Lys Lys Pro Asn
            1460                1465                1470        
Ser Val Pro Gln Glu Leu Ala Ala Thr Thr Glu Lys Thr Glu Pro Asn
        1475                1480                1485            
Ser Gln Glu Asp Lys Asn Asp Gly Gly Lys Ser Arg Lys Gly Asn Ile
    1490                1495                1500                
Glu Leu Ala Ser Ser Glu Pro Gln His Phe Thr Thr Thr Val Thr Arg
1505                1510                1515                1520
Cys Ser Pro Thr Val Ala Phe Val Glu Phe Pro Ser Ser Pro Gln Leu
                1525                1530                1535    
Lys Asn Asp Val Ser Glu Glu Lys Asp Gln Lys Lys Pro Glu Asn Glu
            1540                1545                1550        
Met Ser Gly Lys Val Glu Leu Val Leu Ser Gln Lys Val Val Lys Pro
        1555                1560                1565            
Lys Ser Pro Glu Pro Glu Ala Thr Leu Thr Phe Pro Phe Leu Asp Lys
    1570                1575                1580                
Met Pro Glu Ala Asn Gln Leu His Leu Pro Asn Leu Asn Ser Gln Val
1585                1590                1595                1600
Asp Ser Pro Ser Ser Glu Lys Ser Pro Val Met Thr Pro Phe Lys Phe
                1605                1610                1615    
Trp Ala Trp Asp Pro Glu Glu Glu Arg Arg Arg Gln Glu Lys Trp Gln
            1620                1625                1630        
Gln Glu Gln Glu Arg Leu Leu Gln Glu Arg Tyr Gln Lys Glu Gln Asp
        1635                1640                1645            
Lys Leu Lys Glu Glu Trp Glu Lys Ala Gln Lys Glu Val Glu Glu Glu
    1650                1655                1660                
Glu Arg Arg Tyr Tyr Glu Glu Glu Arg Lys Ile Ile Glu Asp Thr Val
1665                1670                1675                1680
Val Pro Phe Thr Val Ser Ser Ser Ser Ala Asp Gln Leu Ser Thr Ser
                1685                1690                1695    
Ser Ser Met Thr Glu Gly Ser Gly Thr Met Asn Lys Ile Asp Leu Gly
            1700                1705                1710        
Asn Cys Gln Asp Glu Lys Gln Asp Arg Arg Trp Lys Lys Ser Phe Gln
        1715                1720                1725            
Gly Asp Asp Ser Asp Leu Leu Leu Lys Thr Arg Glu Ser Asp Arg Leu
    1730                1735                1740                
Glu Glu Lys Gly Ser Leu Thr Glu Gly Ala Leu Ala His Ser Gly Asn
1745                1750                1755                1760
Pro Val Ser Lys Gly Val His Glu Asp His Gln Leu Asp Thr Glu Ala
                1765                1770                1775    
Gly Ala Pro His Cys Gly Thr Asn Pro Gln Leu Ala Gln Asp Pro Ser
            1780                1785                1790        
Gln Asn Gln Gln Thr Ser Asn Pro Thr His Ser Ser Glu Asp Val Lys
        1795                1800                1805            
Pro Lys Thr Leu Pro Leu Asp Lys Ser Ile Asn His Gln Ile Glu Ser
    1810                1815                1820                
Pro Ser Glu Arg Arg Lys Ser Ile Ser Gly Lys Lys Leu Cys Ser Ser
1825                1830                1835                1840
Cys Gly Leu Pro Leu Gly Lys Gly Ala Ala Met Ile Ile Glu Thr Leu
                1845                1850                1855    
Asn Leu Tyr Phe His Ile Gln Cys Phe Arg Val Arg Thr Tyr Cys Phe
            1860                1865                1870        
Ala Leu Gln Thr Gln Leu His Asp Val Phe Trp His Arg Ser Val Leu
        1875                1880                1885            
Lys Asn Ala Ser Trp Lys Phe Trp Arg Ala Leu Ser Cys Gly Ile Cys
    1890                1895                1900                
Lys Gly Gln Leu Gly Asp Ala Val Ser Gly Thr Asp Val Arg Ile Arg
1905                1910                1915                1920
Asn Gly Leu Leu Asn Cys Asn Asp Cys Tyr Met Arg Ser Arg Ser Met
                1925                1930                1935    
Ser Leu Asp Asp Trp His His Leu Gly Met Val Lys Cys Gly Glu Arg
            1940                1945                1950        
Leu Ser Thr Val Ser Gln Ile Glu His Gln Leu Ile Asn Val Ser Thr
        1955                1960                1965            
Pro Tyr Ile Gln Glu Phe His Tyr Val Ile Cys Val Pro Asn
    1970                1975                1980        


<210> 7461
<211> 3677
<212> PRT
<213> Homo sapiens

<400> 7461
Met Glu Asp Glu Arg Glu Asp Val Gln Lys Lys Thr Phe Thr Lys Trp
 1               5                  10                  15      
Val Asn Ala Gln Phe Ser Lys Phe Gly Lys Gln His Ile Glu Asn Leu
            20                  25                  30          
Phe Ser Asp Leu Gln Asp Gly Arg Arg Leu Leu Asp Leu Leu Glu Gly
        35                  40                  45              
Leu Thr Gly Gln Lys Leu Pro Lys Glu Lys Gly Ser Thr Arg Val His
    50                  55                  60                  
Ala Leu Asn Asn Val Asn Lys Ala Leu Arg Val Leu Gln Asn Asn Asn
65                  70                  75                  80  
Val Asp Leu Val Asn Ile Gly Ser Thr Asp Ile Val Asp Gly Asn His
                85                  90                  95      
Lys Leu Thr Leu Gly Leu Ile Trp Asn Ile Ile Leu His Trp Gln Val
            100                 105                 110         
Lys Asn Val Met Lys Asn Ile Met Ala Gly Leu Gln Gln Thr Asn Ser
        115                 120                 125             
Glu Lys Ile Leu Leu Ser Trp Val Arg Gln Ser Thr Arg Asn Tyr Pro
    130                 135                 140                 
Gln Val Asn Val Ile Asn Phe Thr Thr Ser Trp Ser Asp Gly Leu Ala
145                 150                 155                 160 
Leu Asn Ala Leu Ile His Ser His Arg Pro Asp Leu Phe Asp Trp Asn
                165                 170                 175     
Ser Val Val Cys Gln Gln Ser Ala Thr Gln Arg Leu Glu His Ala Phe
            180                 185                 190         
Asn Ile Ala Arg Tyr Gln Leu Gly Ile Glu Lys Leu Leu Asp Pro Glu
        195                 200                 205             
Asp Val Asp Thr Thr Tyr Pro Asp Lys Lys Ser Ile Leu Met Tyr Ile
    210                 215                 220                 
Thr Ser Leu Phe Gln Val Leu Pro Gln Gln Val Ser Ile Glu Ala Ile
225                 230                 235                 240 
Gln Glu Val Glu Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu
                245                 250                 255     
His Phe Gln Leu His His Gln Met His Tyr Ser Gln Gln Ile Thr Val
            260                 265                 270         
Ser Leu Ala Gln Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe
        275                 280                 285             
Lys Ser Tyr Ala Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro
    290                 295                 300                 
Thr Arg Ser Pro Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys
305                 310                 315                 320 
Ser Phe Gly Ser Ser Leu Met Glu Ser Glu Val Asn Leu Asp Arg Tyr
                325                 330                 335     
Gln Thr Ala Leu Glu Glu Val Leu Ser Trp Leu Leu Ser Ala Glu Asp
            340                 345                 350         
Thr Leu Gln Ala Gln Gly Glu Ile Ser Asn Asp Val Glu Val Val Lys
        355                 360                 365             
Asp Gln Phe His Thr His Glu Gly Tyr Met Met Asp Leu Thr Ala His
    370                 375                 380                 
Gln Gly Arg Val Gly Asn Ile Leu Gln Leu Gly Ser Lys Leu Ile Gly
385                 390                 395                 400 
Thr Gly Lys Leu Ser Glu Asp Glu Glu Thr Glu Val Gln Glu Gln Met
                405                 410                 415     
Asn Leu Leu Asn Ser Arg Trp Glu Cys Leu Arg Val Ala Ser Met Glu
            420                 425                 430         
Lys Gln Ser Asn Leu His Arg Val Leu Met Asp Leu Gln Asn Gln Lys
        435                 440                 445             
Leu Lys Glu Leu Asn Asp Trp Leu Thr Lys Thr Glu Glu Arg Thr Arg
    450                 455                 460                 
Lys Met Glu Glu Glu Pro Leu Gly Pro Asp Leu Glu Asp Leu Lys Arg
465                 470                 475                 480 
Gln Val Gln Gln His Lys Val Leu Gln Glu Asp Leu Glu Gln Glu Gln
                485                 490                 495     
Val Arg Val Asn Ser Leu Thr His Met Val Val Val Val Asp Glu Ser
            500                 505                 510         
Ser Gly Asp His Ala Thr Ala Ala Leu Glu Glu Gln Leu Lys Val Leu
        515                 520                 525             
Gly Asp Arg Trp Ala Asn Ile Cys Arg Trp Thr Glu Asp Arg Trp Val
    530                 535                 540                 
Leu Leu Gln Asp Ile Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln
545                 550                 555                 560 
Cys Leu Phe Ser Ala Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys
                565                 570                 575     
Ile His Thr Thr Gly Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu
            580                 585                 590         
Gln Lys Leu Ala Val Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser
        595                 600                 605             
Met Gly Lys Leu Tyr Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys
    610                 615                 620                 
Asn Lys Ser Val Thr Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala
625                 630                 635                 640 
Arg Cys Trp Asp Asn Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln
                645                 650                 655     
Ile Ser Gln Ala Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr
            660                 665                 670         
Val Met Glu Thr Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val
        675                 680                 685             
Lys His Ala Gln Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg
    690                 695                 700                 
Gln Ile Thr Val Asp Ser Glu Ile Arg Lys Arg Leu Asp Val Asp Ile
705                 710                 715                 720 
Thr Glu Leu His Ser Trp Ile Thr Arg Ser Glu Ala Val Leu Gln Ser
                725                 730                 735     
Pro Glu Phe Ala Ile Phe Arg Lys Glu Gly Asn Phe Ser Asp Leu Lys
            740                 745                 750         
Glu Lys Val Asn Ala Ile Glu Arg Glu Lys Ala Glu Lys Phe Arg Lys
        755                 760                 765             
Leu Gln Asp Ala Ser Arg Ser Ala Gln Ala Leu Val Glu Gln Met Val
    770                 775                 780                 
Asn Glu Gly Val Asn Ala Asp Ser Ile Lys Gln Ala Ser Glu Gln Leu
785                 790                 795                 800 
Asn Ser Arg Trp Ile Glu Phe Cys Gln Leu Leu Ser Glu Arg Leu Asn
                805                 810                 815     
Trp Leu Glu Tyr Gln Asn Asn Ile Ile Ala Phe Tyr Asn Gln Leu Gln
            820                 825                 830         
Gln Leu Glu Gln Met Thr Thr Thr Ala Glu Asn Trp Leu Lys Ile Gln
        835                 840                 845             
Pro Thr Thr Pro Ser Glu Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile
    850                 855                 860                 
Cys Lys Asp Glu Val Asn Arg Leu Ser Gly Leu Gln Pro Gln Ile Glu
865                 870                 875                 880 
Arg Leu Lys Ile Gln Ser Ile Ala Leu Lys Glu Lys Gly Gln Gly Pro
                885                 890                 895     
Met Phe Leu Asp Ala Asp Phe Val Ala Phe Thr Asn His Phe Lys Gln
            900                 905                 910         
Val Phe Ser Asp Val Gln Ala Arg Glu Lys Glu Leu Gln Thr Ile Phe
        915                 920                 925             
Asp Thr Leu Pro Pro Met Arg Tyr Gln Glu Thr Met Ser Ala Ile Arg
    930                 935                 940                 
Thr Trp Val Gln Gln Ser Glu Thr Lys Leu Ser Ile Pro Gln Leu Ser
945                 950                 955                 960 
Val Thr Asp Tyr Glu Ile Met Glu Gln Arg Leu Gly Glu Leu Gln Ala
                965                 970                 975     
Leu Gln Ser Ser Leu Gln Glu Gln Gln Ser Gly Leu Tyr Tyr Leu Ser
            980                 985                 990         
Thr Thr Val Lys Glu Met Ser Lys Lys Ala Pro Ser Glu Ile Ser Arg
        995                 1000                1005            
Lys Tyr Gln Ser Glu Phe Glu Glu Ile Glu Gly Arg Trp Lys Lys Leu
    1010                1015                1020                
Ser Ser Gln Leu Val Glu His Cys Gln Lys Leu Glu Glu Gln Met Asn
1025                1030                1035                1040
Lys Leu Arg Lys Ile Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met
                1045                1050                1055    
Ala Glu Val Asp Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp
            1060                1065                1070        
Ser Glu Ile Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser
        1075                1080                1085            
Asp Ile Gln Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly
    1090                1095                1100                
Gln Lys Ile Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu
1105                1110                1115                1120
Thr Glu Leu Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln Gln
                1125                1130                1135    
Val Tyr Ala Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys Thr Val
            1140                1145                1150        
Ser Leu Gln Lys Asp Leu Ser Glu Met His Glu Trp Met Thr Gln Ala
        1155                1160                1165            
Glu Glu Glu Tyr Leu Glu Arg Asp Phe Glu Tyr Lys Thr Pro Asp Glu
    1170                1175                1180                
Leu Gln Lys Ala Val Glu Glu Met Lys Arg Ala Lys Glu Glu Ala Gln
1185                1190                1195                1200
Gln Lys Glu Ala Lys Val Lys Leu Leu Thr Glu Ser Val Asn Ser Val
                1205                1210                1215    
Ile Ala Gln Ala Pro Pro Val Ala Gln Glu Ala Leu Lys Lys Glu Leu
            1220                1225                1230        
Glu Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg Leu Asn Gly
        1235                1240                1245            
Lys Cys Lys Thr Leu Glu Glu Val Trp Ala Cys Trp His Glu Leu Leu
    1250                1255                1260                
Ser Tyr Leu Glu Lys Ala Asn Lys Trp Leu Asn Glu Val Glu Phe Lys
1265                1270                1275                1280
Leu Lys Thr Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu
                1285                1290                1295    
Val Leu Asp Ser Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro
            1300                1305                1310        
Asn Gln Ile Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met
        1315                1320                1325            
Asp Glu Leu Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg
    1330                1335                1340                
Glu Leu His Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser
1345                1350                1355                1360
Ile Gln Ser Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln Glu
                1365                1370                1375    
Ser Leu Thr Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala Asp Lys
            1380                1385                1390        
Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys Ile Gln Ser Asp
        1395                1400                1405            
Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys Lys His Asn Gln
    1410                1415                1420                
Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln Ile Asp Val Ala Gln
1425                1430                1435                1440
Lys Lys Leu Gln Asp Val Ser Met Lys Phe Arg Leu Phe Gln Lys Pro
                1445                1450                1455    
Ala Asn Phe Glu Leu Arg Leu Gln Glu Ser Lys Met Ile Leu Asp Glu
            1460                1465                1470        
Val Lys Met His Leu Pro Ala Leu Glu Thr Lys Ser Val Glu Gln Glu
        1475                1480                1485            
Val Val Gln Ser Gln Leu Asn His Cys Val Asn Leu Tyr Lys Ser Leu
    1490                1495                1500                
Ser Glu Val Lys Ser Glu Val Glu Met Val Ile Lys Thr Gly Arg Gln
1505                1510                1515                1520
Ile Val Gln Lys Lys Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg
                1525                1530                1535    
Val Thr Ala Leu Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr
            1540                1545                1550        
Glu Arg Lys Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met
        1555                1560                1565            
Arg Lys Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met
    1570                1575                1580                
Glu Leu Thr Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp
1585                1590                1595                1600
Ser Glu Val Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys Gln
                1605                1610                1615    
Lys Val His Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu Lys Thr
            1620                1625                1630        
Val Leu Gly Lys Lys Glu Thr Leu Val Glu Asp Lys Leu Ser Leu Leu
        1635                1640                1645            
Asn Ser Asn Trp Ile Ala Val Thr Ser Arg Ala Glu Glu Trp Leu Asn
    1650                1655                1660                
Leu Leu Leu Glu Tyr Gln Lys His Met Glu Thr Phe Asp Gln Asn Val
1665                1670                1675                1680
Asp His Ile Thr Lys Trp Ile Ile Gln Ala Asp Thr Leu Leu Asp Glu
                1685                1690                1695    
Ser Glu Lys Lys Lys Pro Gln Gln Lys Glu Asp Val Leu Lys Arg Leu
            1700                1705                1710        
Lys Ala Glu Leu Asn Asp Ile Arg Pro Lys Val Asp Ser Thr Arg Asp
        1715                1720                1725            
Gln Ala Ala Asn Leu Met Ala Asn Arg Gly Asp His Cys Arg Lys Leu
    1730                1735                1740                
Val Glu Pro Gln Ile Ser Glu Leu Asn His Arg Phe Ala Ala Ile Ser
1745                1750                1755                1760
His Arg Ile Lys Thr Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu
                1765                1770                1775    
Gln Phe Asn Ser Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu
            1780                1785                1790        
Ile Gln Gln Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met
        1795                1800                1805            
Asn Glu Asp Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp
    1810                1815                1820                
Asn Leu Gln Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys
1825                1830                1835                1840
Ile Lys Gln Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp Leu
                1845                1850                1855    
Arg Ser Gln Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln Trp Tyr
            1860                1865                1870        
Gln Tyr Lys Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu Asp Asp Ile
        1875                1880                1885            
Glu Lys Lys Leu Ala Ser Leu Pro Glu Pro Arg Asp Glu Arg Lys Ile
    1890                1895                1900                
Lys Glu Ile Asp Arg Glu Leu Gln Lys Lys Lys Glu Glu Leu Asn Ala
1905                1910                1915                1920
Val Arg Arg Gln Ala Glu Gly Leu Ser Glu Asp Gly Ala Ala Met Ala
                1925                1930                1935    
Val Glu Pro Thr Gln Ile Gln Leu Ser Lys Arg Trp Arg Glu Ile Glu
            1940                1945                1950        
Ser Lys Phe Ala Gln Phe Arg Arg Leu Asn Phe Ala Gln Ile His Thr
        1955                1960                1965            
Val Arg Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu Glu
    1970                1975                1980                
Ile Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser
1985                1990                1995                2000
Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys
                2005                2010                2015    
Ala Lys Asp Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn
            2020                2025                2030        
Ile Lys Asp Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His
        2035                2040                2045            
Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val
    2050                2055                2060                
Lys Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val
2065                2070                2075                2080
Asn Lys Met Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu
                2085                2090                2095    
Lys Trp Arg Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu
            2100                2105                2110        
Thr Glu Ala Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp
        2115                2120                2125            
Glu His Ala Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile
    2130                2135                2140                
Gly Gln Arg Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu
2145                2150                2155                2160
Ile Ile Gln Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys
                2165                2170                2175    
Leu Gly Ser Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser
            2180                2185                2190        
Asp Arg Lys Lys Arg Leu Glu Glu Gln Lys Asn Ile Leu Ser Glu Phe
        2195                2200                2205            
Gln Arg Asp Leu Asn Glu Phe Val Leu Trp Leu Glu Glu Ala Asp Asn
    2210                2215                2220                
Ile Ala Ser Ile Pro Leu Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu
2225                2230                2235                2240
Lys Leu Glu Gln Val Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln
                2245                2250                2255    
Gly Ile Leu Lys Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser
            2260                2265                2270        
Ala Pro Ile Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys
        2275                2280                2285            
Gln Thr Asn Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys
    2290                2295                2300                
Gln Gly Glu Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys
2305                2310                2315                2320
Lys Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp Leu
                2325                2330                2335    
Ser Pro Ile Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn Gln Glu
            2340                2345                2350        
Gly Pro Phe Asp Val Gln Glu Thr Glu Ile Ala Val Gln Ala Lys Gln
        2355                2360                2365            
Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His Leu Tyr Lys Glu
    2370                2375                2380                
Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu Glu Asp Leu Ser Ser
2385                2390                2395                2400
Glu Trp Lys Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln
                2405                2410                2415    
Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln
            2420                2425                2430        
Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile
        2435                2440                2445            
Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu
    2450                2455                2460                
Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu
2465                2470                2475                2480
Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu
                2485                2490                2495    
Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu
            2500                2505                2510        
Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn
        2515                2520                2525            
Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp
    2530                2535                2540                
Arg Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu
2545                2550                2555                2560
Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln
                2565                2570                2575    
Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg
            2580                2585                2590        
Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile
        2595                2600                2605            
Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln
    2610                2615                2620                
Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu
2625                2630                2635                2640
Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu
                2645                2650                2655    
Asn Ile Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg
            2660                2665                2670        
Glu Ala Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu
        2675                2680                2685            
Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala
    2690                2695                2700                
Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg Glu Leu Glu Asp Ser
2705                2710                2715                2720
Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu
                2725                2730                2735    
Ile Glu Ala His Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln
            2740                2745                2750        
Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln
        2755                2760                2765            
Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser Leu Leu Arg Lys Lys
    2770                2775                2780                
Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys
2785                2790                2795                2800
Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys
                2805                2810                2815    
Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala
            2820                2825                2830        
Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys
        2835                2840                2845            
Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe
    2850                2855                2860                
Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro
2865                2870                2875                2880
Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu
                2885                2890                2895    
Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu
            2900                2905                2910        
His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu
        2915                2920                2925            
Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln
    2930                2935                2940                
Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile
2945                2950                2955                2960
Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu
                2965                2970                2975    
Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg
            2980                2985                2990        
Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr
        2995                3000                3005            
Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu
    3010                3015                3020                
Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala
3025                3030                3035                3040
Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala
                3045                3050                3055    
Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr
            3060                3065                3070        
Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala
        3075                3080                3085            
Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu
    3090                3095                3100                
Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala
3105                3110                3115                3120
Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro
                3125                3130                3135    
Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg
            3140                3145                3150        
Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp
        3155                3160                3165            
Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly
    3170                3175                3180                
Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys
3185                3190                3195                3200
Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser
                3205                3210                3215    
Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp
            3220                3225                3230        
Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly
        3235                3240                3245            
Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn
    3250                3255                3260                
Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu
3265                3270                3275                3280
Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala
                3285                3290                3295    
Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro
            3300                3305                3310        
Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile
        3315                3320                3325            
Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met
    3330                3335                3340                
His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp
3345                3350                3355                3360
Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg
                3365                3370                3375    
Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val
            3380                3385                3390        
Leu Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp
        3395                3400                3405            
Pro Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp
    3410                3415                3420                
Thr His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu
3425                3430                3435                3440
Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser
                3445                3450                3455    
Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn
            3460                3465                3470        
Gln Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile
        3475                3480                3485            
Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp
    3490                3495                3500                
Leu Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys
3505                3510                3515                3520
Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu
                3525                3530                3535    
Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala
            3540                3545                3550        
Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met
        3555                3560                3565            
Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg
    3570                3575                3580                
Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly
3585                3590                3595                3600
Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser
                3605                3610                3615    
Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met
            3620                3625                3630        
Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu
        3635                3640                3645            
Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly
    3650                3655                3660                
Arg Asn Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met
3665                3670                3675        


<210> 7462
<211> 3685
<212> PRT
<213> Homo sapiens

<400> 7462
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val
 1               5                  10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr
            660                 665                 670         
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val
        675                 680                 685             
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro
    690                 695                 700                 
Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile
705                 710                 715                 720 
Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr
                725                 730                 735     
Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys
            740                 745                 750         
Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg
        755                 760                 765             
Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala
    770                 775                 780                 
Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser
785                 790                 795                 800 
Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys
                805                 810                 815     
Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile
            820                 825                 830         
Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr
        835                 840                 845             
Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr
    850                 855                 860                 
Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu
865                 870                 875                 880 
Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala
                885                 890                 895     
Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val
            900                 905                 910         
Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg
        915                 920                 925             
Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr
    930                 935                 940                 
Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr
945                 950                 955                 960 
Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu
                965                 970                 975     
Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln
            980                 985                 990         
Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys
        995                 1000                1005            
Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu Glu
    1010                1015                1020                
Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu His Cys
1025                1030                1035                1040
Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile Gln Asn His
                1045                1050                1055    
Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp Val Phe Leu Lys
            1060                1065                1070        
Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile Leu Lys Lys Gln Leu
        1075                1080                1085            
Lys Gln Cys Arg Leu Leu Val Ser Asp Ile Gln Thr Ile Gln Pro Ser
    1090                1095                1100                
Leu Asn Ser Val Asn Glu Gly Gly Gln Lys Ile Lys Asn Glu Ala Glu
1105                1110                1115                1120
Pro Glu Phe Ala Ser Arg Leu Glu Thr Glu Leu Lys Glu Leu Asn Thr
                1125                1130                1135    
Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala Arg Lys Glu Ala Leu
            1140                1145                1150        
Lys Gly Gly Leu Glu Lys Thr Val Ser Leu Gln Lys Asp Leu Ser Glu
        1155                1160                1165            
Met His Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp
    1170                1175                1180                
Phe Glu Tyr Lys Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met
1185                1190                1195                1200
Lys Arg Ala Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu
                1205                1210                1215    
Leu Thr Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala
            1220                1225                1230        
Gln Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln
        1235                1240                1245            
Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val
    1250                1255                1260                
Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys
1265                1270                1275                1280
Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro
                1285                1290                1295    
Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu
            1300                1305                1310        
Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln
        1315                1320                1325            
Thr Leu Thr Asp Gly Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu
    1330                1335                1340                
Glu Thr Phe Asn Ser Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg
1345                1350                1355                1360
Arg Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln Glu Thr Glu
                1365                1370                1375    
Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile Asp Lys Gln
            1380                1385                1390        
Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala Ala Gln Met Pro Gln
        1395                1400                1405            
Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu
    1410                1415                1420                
Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val
1425                1430                1435                1440
Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met
                1445                1450                1455    
Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Leu Arg Leu Gln
            1460                1465                1470        
Glu Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu
        1475                1480                1485            
Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn His
    1490                1495                1500                
Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu Val Glu
1505                1510                1515                1520
Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys Gln Thr Glu
                1525                1530                1535    
Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr
            1540                1545                1550        
Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu Lys
        1555                1560                1565            
Cys Leu Lys Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val Leu Thr
    1570                1575                1580                
Glu Trp Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg Ser Ala Val
1585                1590                1595                1600
Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp Gly Lys Ala
                1605                1610                1615    
Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys Ser Ile Thr
            1620                1625                1630        
Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys Glu Thr Leu
        1635                1640                1645            
Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr
    1650                1655                1660                
Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His
1665                1670                1675                1680
Met Glu Thr Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile
                1685                1690                1695    
Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln
            1700                1705                1710        
Lys Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg
        1715                1720                1725            
Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala Asn
    1730                1735                1740                
Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser Glu Leu
1745                1750                1755                1760
Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr Gly Lys Ala
                1765                1770                1775    
Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys
            1780                1785                1790        
Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys
        1795                1800                1805            
Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val
    1810                1815                1820                
Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp
1825                1830                1835                1840
Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr
                1845                1850                1855    
Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys Ala
            1860                1865                1870        
Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp
        1875                1880                1885            
Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro
    1890                1895                1900                
Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln
1905                1910                1915                1920
Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu
                1925                1930                1935    
Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu
            1940                1945                1950        
Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg
        1955                1960                1965            
Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val
    1970                1975                1980                
Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr
1985                1990                1995                2000
Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln
                2005                2010                2015    
Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe
            2020                2025                2030        
Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser
        2035                2040                2045            
Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln
    2050                2055                2060                
Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln
2065                2070                2075                2080
Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln
                2085                2090                2095    
Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp
            2100                2105                2110        
Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg
        2115                2120                2125            
Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr
    2130                2135                2140                
Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg
2145                2150                2155                2160
Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr
                2165                2170                2175    
Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp
            2180                2185                2190        
Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu
        2195                2200                2205            
Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe Val
    2210                2215                2220                
Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu Glu Pro
2225                2230                2235                2240
Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val Lys Leu Leu
                2245                2250                2255    
Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu
            2260                2265                2270        
Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu Gln
        2275                2280                2285            
Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys
    2290                2295                2300                
Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile
2305                2310                2315                2320
Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln
                2325                2330                2335    
Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn Gln Leu Glu
            2340                2345                2350        
Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp Val Gln Glu Thr
        2355                2360                2365            
Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser
    2370                2375                2380                
Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys
2385                2390                2395                2400
Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu
                2405                2410                2415    
Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr
            2420                2425                2430        
Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro
        2435                2440                2445            
Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser
    2450                2455                2460                
Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr
2465                2470                2475                2480
Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile Lys Ser Gln
                2485                2490                2495    
Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys
            2500                2505                2510        
Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu
        2515                2520                2525            
Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln
    2530                2535                2540                
Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln
2545                2550                2555                2560
Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn
                2565                2570                2575    
Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala
            2580                2585                2590        
Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu
        2595                2600                2605            
Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys
    2610                2615                2620                
Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala
2625                2630                2635                2640
Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr
                2645                2650                2655    
Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser
            2660                2665                2670        
Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His
        2675                2680                2685            
Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp
    2690                2695                2700                
Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg
2705                2710                2715                2720
Lys Glu Arg Glu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys
                2725                2730                2735    
Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr
            2740                2745                2750        
His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly
        2755                2760                2765            
Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe
    2770                2775                2780                
Lys Trp Ser Leu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu
2785                2790                2795                2800
Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu
                2805                2810                2815    
Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala
            2820                2825                2830        
Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His
        2835                2840                2845            
Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser
    2850                2855                2860                
Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly
2865                2870                2875                2880
Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg
                2885                2890                2895    
Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn
            2900                2905                2910        
Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys
        2915                2920                2925            
Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp
    2930                2935                2940                
Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp
2945                2950                2955                2960
Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu
                2965                2970                2975    
Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val
            2980                2985                2990        
Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln
        2995                3000                3005            
Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp
    3010                3015                3020                
Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu
3025                3030                3035                3040
Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser
                3045                3050                3055    
Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr
            3060                3065                3070        
Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met
        3075                3080                3085            
Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser
    3090                3095                3100                
Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys
3105                3110                3115                3120
Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His
                3125                3130                3135    
Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn
            3140                3145                3150        
Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu
        3155                3160                3165            
Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn
    3170                3175                3180                
Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys
3185                3190                3195                3200
Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg
                3205                3210                3215    
Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg
            3220                3225                3230        
Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu
        3235                3240                3245            
Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg
    3250                3255                3260                
Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu
3265                3270                3275                3280
Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro
                3285                3290                3295    
Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys
            3300                3305                3310        
Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser
        3315                3320                3325            
Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly
    3330                3335                3340                
Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys
3345                3350                3355                3360
Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu
                3365                3370                3375    
Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met
            3380                3385                3390        
Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr
        3395                3400                3405            
Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser
    3410                3415                3420                
Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His Tyr
3425                3430                3435                3440
Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn
                3445                3450                3455    
Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile
            3460                3465                3470        
Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro
        3475                3480                3485            
Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly
    3490                3495                3500                
Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu
3505                3510                3515                3520
Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu
                3525                3530                3535    
Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser
            3540                3545                3550        
Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His
        3555                3560                3565            
Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys
    3570                3575                3580                
Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro
3585                3590                3595                3600
Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr
                3605                3610                3615    
Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val
            3620                3625                3630        
Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro
        3635                3640                3645            
Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn
    3650                3655                3660                
Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met
3665                3670                3675                3680
Arg Glu Asp Thr Met
                3685


<210> 7463
<211> 3685
<212> PRT
<213> Homo sapiens

<400> 7463
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val
 1               5                  10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr
            660                 665                 670         
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val
        675                 680                 685             
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro
    690                 695                 700                 
Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile
705                 710                 715                 720 
Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr
                725                 730                 735     
Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys
            740                 745                 750         
Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg
        755                 760                 765             
Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala
    770                 775                 780                 
Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser
785                 790                 795                 800 
Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys
                805                 810                 815     
Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile
            820                 825                 830         
Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr
        835                 840                 845             
Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr
    850                 855                 860                 
Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu
865                 870                 875                 880 
Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala
                885                 890                 895     
Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val
            900                 905                 910         
Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg
        915                 920                 925             
Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr
    930                 935                 940                 
Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr
945                 950                 955                 960 
Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu
                965                 970                 975     
Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln
            980                 985                 990         
Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys
        995                 1000                1005            
Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu Glu
    1010                1015                1020                
Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu His Cys
1025                1030                1035                1040
Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile Gln Asn His
                1045                1050                1055    
Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp Val Phe Leu Lys
            1060                1065                1070        
Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile Leu Lys Lys Gln Leu
        1075                1080                1085            
Lys Gln Cys Arg Leu Leu Val Ser Asp Ile Gln Thr Ile Gln Pro Ser
    1090                1095                1100                
Leu Asn Ser Val Asn Glu Gly Gly Gln Lys Ile Lys Asn Glu Ala Glu
1105                1110                1115                1120
Pro Glu Phe Ala Ser Arg Leu Glu Thr Glu Leu Lys Glu Leu Asn Thr
                1125                1130                1135    
Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala Arg Lys Glu Ala Leu
            1140                1145                1150        
Lys Gly Gly Leu Glu Lys Thr Val Ser Leu Gln Lys Asp Leu Ser Glu
        1155                1160                1165            
Met His Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp
    1170                1175                1180                
Phe Glu Tyr Lys Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met
1185                1190                1195                1200
Lys Arg Ala Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu
                1205                1210                1215    
Leu Thr Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala
            1220                1225                1230        
Gln Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln
        1235                1240                1245            
Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val
    1250                1255                1260                
Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys
1265                1270                1275                1280
Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro
                1285                1290                1295    
Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu
            1300                1305                1310        
Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln
        1315                1320                1325            
Thr Leu Thr Asp Gly Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu
    1330                1335                1340                
Glu Thr Phe Asn Ser Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg
1345                1350                1355                1360
Arg Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln Glu Thr Glu
                1365                1370                1375    
Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile Asp Lys Gln
            1380                1385                1390        
Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala Ala Gln Met Pro Gln
        1395                1400                1405            
Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu
    1410                1415                1420                
Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val
1425                1430                1435                1440
Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met
                1445                1450                1455    
Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Leu Arg Leu Gln
            1460                1465                1470        
Glu Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu
        1475                1480                1485            
Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn His
    1490                1495                1500                
Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu Val Glu
1505                1510                1515                1520
Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys Gln Thr Glu
                1525                1530                1535    
Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr
            1540                1545                1550        
Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu Lys
        1555                1560                1565            
Cys Leu Lys Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val Leu Thr
    1570                1575                1580                
Glu Trp Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg Ser Ala Val
1585                1590                1595                1600
Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp Gly Lys Ala
                1605                1610                1615    
Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys Ser Ile Thr
            1620                1625                1630        
Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys Glu Thr Leu
        1635                1640                1645            
Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr
    1650                1655                1660                
Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His
1665                1670                1675                1680
Met Glu Thr Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile
                1685                1690                1695    
Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln
            1700                1705                1710        
Lys Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg
        1715                1720                1725            
Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala Asn
    1730                1735                1740                
Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser Glu Leu
1745                1750                1755                1760
Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr Gly Lys Ala
                1765                1770                1775    
Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys
            1780                1785                1790        
Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys
        1795                1800                1805            
Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val
    1810                1815                1820                
Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp
1825                1830                1835                1840
Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr
                1845                1850                1855    
Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys Ala
            1860                1865                1870        
Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp
        1875                1880                1885            
Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro
    1890                1895                1900                
Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln
1905                1910                1915                1920
Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu
                1925                1930                1935    
Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu
            1940                1945                1950        
Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg
        1955                1960                1965            
Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val
    1970                1975                1980                
Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr
1985                1990                1995                2000
Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln
                2005                2010                2015    
Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe
            2020                2025                2030        
Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser
        2035                2040                2045            
Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln
    2050                2055                2060                
Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln
2065                2070                2075                2080
Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln
                2085                2090                2095    
Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp
            2100                2105                2110        
Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg
        2115                2120                2125            
Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr
    2130                2135                2140                
Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg
2145                2150                2155                2160
Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr
                2165                2170                2175    
Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp
            2180                2185                2190        
Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu
        2195                2200                2205            
Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe Val
    2210                2215                2220                
Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu Glu Pro
2225                2230                2235                2240
Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val Lys Leu Leu
                2245                2250                2255    
Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu
            2260                2265                2270        
Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu Gln
        2275                2280                2285            
Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys
    2290                2295                2300                
Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile
2305                2310                2315                2320
Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln
                2325                2330                2335    
Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn Gln Leu Glu
            2340                2345                2350        
Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp Val Gln Glu Thr
        2355                2360                2365            
Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser
    2370                2375                2380                
Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys
2385                2390                2395                2400
Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu
                2405                2410                2415    
Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr
            2420                2425                2430        
Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro
        2435                2440                2445            
Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser
    2450                2455                2460                
Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr
2465                2470                2475                2480
Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile Lys Ser Gln
                2485                2490                2495    
Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys
            2500                2505                2510        
Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu
        2515                2520                2525            
Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln
    2530                2535                2540                
Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln
2545                2550                2555                2560
Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn
                2565                2570                2575    
Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala
            2580                2585                2590        
Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu
        2595                2600                2605            
Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys
    2610                2615                2620                
Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala
2625                2630                2635                2640
Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr
                2645                2650                2655    
Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser
            2660                2665                2670        
Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His
        2675                2680                2685            
Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp
    2690                2695                2700                
Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg
2705                2710                2715                2720
Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys
                2725                2730                2735    
Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr
            2740                2745                2750        
His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly
        2755                2760                2765            
Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe
    2770                2775                2780                
Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu
2785                2790                2795                2800
Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu
                2805                2810                2815    
Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala
            2820                2825                2830        
Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His
        2835                2840                2845            
Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser
    2850                2855                2860                
Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly
2865                2870                2875                2880
Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg
                2885                2890                2895    
Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn
            2900                2905                2910        
Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys
        2915                2920                2925            
Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp
    2930                2935                2940                
Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp
2945                2950                2955                2960
Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu
                2965                2970                2975    
Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val
            2980                2985                2990        
Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln
        2995                3000                3005            
Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp
    3010                3015                3020                
Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu
3025                3030                3035                3040
Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser
                3045                3050                3055    
Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr
            3060                3065                3070        
Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met
        3075                3080                3085            
Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser
    3090                3095                3100                
Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys
3105                3110                3115                3120
Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His
                3125                3130                3135    
Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn
            3140                3145                3150        
Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu
        3155                3160                3165            
Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn
    3170                3175                3180                
Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys
3185                3190                3195                3200
Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg
                3205                3210                3215    
Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg
            3220                3225                3230        
Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu
        3235                3240                3245            
Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg
    3250                3255                3260                
Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu
3265                3270                3275                3280
Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro
                3285                3290                3295    
Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys
            3300                3305                3310        
Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser
        3315                3320                3325            
Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly
    3330                3335                3340                
Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys
3345                3350                3355                3360
Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu
                3365                3370                3375    
Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met
            3380                3385                3390        
Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr
        3395                3400                3405            
Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser
    3410                3415                3420                
Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His Tyr
3425                3430                3435                3440
Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn
                3445                3450                3455    
Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile
            3460                3465                3470        
Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro
        3475                3480                3485            
Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly
    3490                3495                3500                
Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu
3505                3510                3515                3520
Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu
                3525                3530                3535    
Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser
            3540                3545                3550        
Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His
        3555                3560                3565            
Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys
    3570                3575                3580                
Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro
3585                3590                3595                3600
Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr
                3605                3610                3615    
Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val
            3620                3625                3630        
Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro
        3635                3640                3645            
Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn
    3650                3655                3660                
Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met
3665                3670                3675                3680
Arg Glu Asp Thr Met
                3685


<210> 7464
<211> 3562
<212> PRT
<213> Homo sapiens

<400> 7464
Met Lys Asn Ile Met Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile
 1               5                  10                  15      
Leu Leu Ser Trp Val Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn
            20                  25                  30          
Val Ile Asn Phe Thr Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala
        35                  40                  45              
Leu Ile His Ser His Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val
    50                  55                  60                  
Cys Gln Gln Ser Ala Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala
65                  70                  75                  80  
Arg Tyr Gln Leu Gly Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp
                85                  90                  95      
Thr Thr Tyr Pro Asp Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu
            100                 105                 110         
Phe Gln Val Leu Pro Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val
        115                 120                 125             
Glu Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln
    130                 135                 140                 
Leu His His Gln Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala
145                 150                 155                 160 
Gln Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr
                165                 170                 175     
Ala Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser
            180                 185                 190         
Pro Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly
        195                 200                 205             
Ser Ser Leu Met Glu Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala
    210                 215                 220                 
Leu Glu Glu Val Leu Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln
225                 230                 235                 240 
Ala Gln Gly Glu Ile Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe
                245                 250                 255     
His Thr His Glu Gly Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg
            260                 265                 270         
Val Gly Asn Ile Leu Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys
        275                 280                 285             
Leu Ser Glu Asp Glu Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu
    290                 295                 300                 
Asn Ser Arg Trp Glu Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser
305                 310                 315                 320 
Asn Leu His Arg Val Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu
                325                 330                 335     
Leu Asn Asp Trp Leu Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu
            340                 345                 350         
Glu Glu Pro Leu Gly Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln
        355                 360                 365             
Gln His Lys Val Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val
    370                 375                 380                 
Asn Ser Leu Thr His Met Val Val Val Val Asp Glu Ser Ser Gly Asp
385                 390                 395                 400 
His Ala Thr Ala Ala Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg
                405                 410                 415     
Trp Ala Asn Ile Cys Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln
            420                 425                 430         
Asp Ile Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe
        435                 440                 445             
Ser Ala Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr
    450                 455                 460                 
Thr Gly Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu
465                 470                 475                 480 
Ala Val Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys
                485                 490                 495     
Leu Tyr Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser
            500                 505                 510         
Val Thr Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp
        515                 520                 525             
Asp Asn Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln
    530                 535                 540                 
Ala Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu
545                 550                 555                 560 
Thr Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala
                565                 570                 575     
Gln Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr
            580                 585                 590         
Val Asp Ser Glu Ile Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu
        595                 600                 605             
His Ser Trp Ile Thr Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe
    610                 615                 620                 
Ala Ile Phe Arg Lys Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val
625                 630                 635                 640 
Asn Ala Ile Glu Arg Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp
                645                 650                 655     
Ala Ser Arg Ser Ala Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly
            660                 665                 670         
Val Asn Ala Asp Ser Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg
        675                 680                 685             
Trp Ile Glu Phe Cys Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu
    690                 695                 700                 
Tyr Gln Asn Asn Ile Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu
705                 710                 715                 720 
Gln Met Thr Thr Thr Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr
                725                 730                 735     
Pro Ser Glu Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp
            740                 745                 750         
Glu Val Asn Arg Leu Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys
        755                 760                 765             
Ile Gln Ser Ile Ala Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu
    770                 775                 780                 
Asp Ala Asp Phe Val Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser
785                 790                 795                 800 
Asp Val Gln Ala Arg Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu
                805                 810                 815     
Pro Pro Met Arg Tyr Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val
            820                 825                 830         
Gln Gln Ser Glu Thr Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp
        835                 840                 845             
Tyr Glu Ile Met Glu Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser
    850                 855                 860                 
Ser Leu Gln Glu Gln Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val
865                 870                 875                 880 
Lys Glu Met Ser Lys Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln
                885                 890                 895     
Ser Glu Phe Glu Glu Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln
            900                 905                 910         
Leu Val Glu His Cys Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg
        915                 920                 925             
Lys Ile Gln Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val
    930                 935                 940                 
Asp Val Phe Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile
945                 950                 955                 960 
Leu Lys Lys Gln Leu Lys Gln Cys Arg Leu Leu Val Ser Asp Ile Gln
                965                 970                 975     
Thr Ile Gln Pro Ser Leu Asn Ser Val Asn Glu Gly Gly Gln Lys Ile
            980                 985                 990         
Lys Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg Leu Glu Thr Glu Leu
        995                 1000                1005            
Lys Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala
    1010                1015                1020                
Arg Lys Glu Ala Leu Lys Gly Gly Leu Glu Lys Thr Val Ser Leu Gln
1025                1030                1035                1040
Lys Asp Leu Ser Glu Met His Glu Trp Met Thr Gln Ala Glu Glu Glu
                1045                1050                1055    
Tyr Leu Glu Arg Asp Phe Glu Tyr Lys Thr Pro Asp Glu Leu Gln Lys
            1060                1065                1070        
Ala Val Glu Glu Met Lys Arg Ala Lys Glu Glu Ala Gln Gln Lys Glu
        1075                1080                1085            
Ala Lys Val Lys Leu Leu Thr Glu Ser Val Asn Ser Val Ile Ala Gln
    1090                1095                1100                
Ala Pro Pro Val Ala Gln Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu
1105                1110                1115                1120
Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys
                1125                1130                1135    
Thr Leu Glu Glu Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu
            1140                1145                1150        
Glu Lys Ala Asn Lys Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr
        1155                1160                1165            
Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp
    1170                1175                1180                
Ser Leu Glu Asn Leu Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile
1185                1190                1195                1200
Arg Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu Leu
                1205                1210                1215    
Ile Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg Trp Arg Glu Leu His
            1220                1225                1230        
Glu Glu Ala Val Arg Arg Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser
        1235                1240                1245            
Ala Gln Glu Thr Glu Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr
    1250                1255                1260                
Phe Ile Asp Lys Gln Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala
1265                1270                1275                1280
Ala Gln Met Pro Gln Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser
                1285                1290                1295    
His Glu Ile Ser Leu Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu
            1300                1305                1310        
Ala Ala Gln Arg Val Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu
        1315                1320                1325            
Gln Asp Val Ser Met Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn Phe
    1330                1335                1340                
Glu Gln Arg Leu Gln Glu Ser Lys Met Ile Leu Asp Glu Val Lys Met
1345                1350                1355                1360
His Leu Pro Ala Leu Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln
                1365                1370                1375    
Ser Gln Leu Asn His Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val
            1380                1385                1390        
Lys Ser Glu Val Glu Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln
        1395                1400                1405            
Lys Lys Gln Thr Glu Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala
    1410                1415                1420                
Leu Lys Leu His Tyr Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys
1425                1430                1435                1440
Gln Gln Leu Glu Lys Cys Leu Lys Leu Ser Arg Lys Met Arg Lys Glu
                1445                1450                1455    
Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu Leu Thr
            1460                1465                1470        
Lys Arg Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val
        1475                1480                1485            
Ala Trp Gly Lys Ala Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His
    1490                1495                1500                
Leu Lys Ser Ile Thr Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly
1505                1510                1515                1520
Lys Lys Glu Thr Leu Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn
                1525                1530                1535    
Trp Ile Ala Val Thr Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu
            1540                1545                1550        
Glu Tyr Gln Lys His Met Glu Thr Phe Asp Gln Asn Val Asp His Ile
        1555                1560                1565            
Thr Lys Trp Ile Ile Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys
    1570                1575                1580                
Lys Lys Pro Gln Gln Lys Glu Asp Val Leu Lys Arg Leu Lys Ala Glu
1585                1590                1595                1600
Leu Asn Asp Ile Arg Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala
                1605                1610                1615    
Asn Leu Met Ala Asn Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro
            1620                1625                1630        
Gln Ile Ser Glu Leu Asn His Arg Phe Ala Ala Ile Ser His Arg Ile
        1635                1640                1645            
Lys Thr Gly Lys Ala Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn
    1650                1655                1660                
Ser Asp Ile Gln Lys Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln
1665                1670                1675                1680
Gly Val Asn Leu Lys Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp
                1685                1690                1695    
Asn Glu Gly Thr Val Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln
            1700                1705                1710        
Gln Arg Ile Thr Asp Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln
        1715                1720                1725            
Gln Leu Leu Gln Thr Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln
    1730                1735                1740                
Arg Arg Lys Lys Ala Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys
1745                1750                1755                1760
Arg Gln Ala Asp Asp Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys
                1765                1770                1775    
Leu Ala Ser Leu Pro Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile
            1780                1785                1790        
Asp Arg Glu Leu Gln Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg
        1795                1800                1805            
Gln Ala Glu Gly Leu Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro
    1810                1815                1820                
Thr Gln Ile Gln Leu Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe
1825                1830                1835                1840
Ala Gln Phe Arg Arg Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu
                1845                1850                1855    
Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr
            1860                1865                1870        
Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu
        1875                1880                1885            
Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp
    1890                1895                1900                
Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp
1905                1910                1915                1920
Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys
                1925                1930                1935    
Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln
            1940                1945                1950        
Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met
        1955                1960                1965            
Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg
    1970                1975                1980                
Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala
1985                1990                1995                2000
Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala
                2005                2010                2015    
Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg
            2020                2025                2030        
Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln
        2035                2040                2045            
Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser
    2050                2055                2060                
Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys
2065                2070                2075                2080
Lys Arg Leu Glu Glu Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp
                2085                2090                2095    
Leu Asn Glu Phe Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser
            2100                2105                2110        
Ile Pro Leu Glu Pro Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu
        2115                2120                2125            
Gln Val Lys Leu Leu Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu
    2130                2135                2140                
Lys Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile
2145                2150                2155                2160
Ser Pro Glu Glu Gln Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn
                2165                2170                2175    
Leu Gln Trp Ile Lys Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu
            2180                2185                2190        
Ile Glu Ala Gln Ile Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu
        2195                2200                2205            
Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile
    2210                2215                2220                
Arg Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe
2225                2230                2235                2240
Asp Val Gln Glu Thr Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val
                2245                2250                2255    
Glu Glu Ile Leu Ser Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala
            2260                2265                2270        
Thr Gln Pro Val Lys Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys
        2275                2280                2285            
Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp Leu
    2290                2295                2300                
Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr
2305                2310                2315                2320
Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu
                2325                2330                2335    
Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe
            2340                2345                2350        
Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln
        2355                2360                2365            
Val Ile Lys Ser Gln Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn
    2370                2375                2380                
Glu Met Ile Ile Lys Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg
2385                2390                2395                2400
Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn
                2405                2410                2415    
Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu
            2420                2425                2430        
Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg
        2435                2440                2445            
Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu
    2450                2455                2460                
Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu
2465                2470                2475                2480
Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys
                2485                2490                2495    
Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr
            2500                2505                2510        
Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr
        2515                2520                2525            
Ser Ala Asp Asp Thr Arg Lys Val His Met Ile Thr Glu Asn Ile Asn
    2530                2535                2540                
Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala
2545                2550                2555                2560
Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu
                2565                2570                2575    
Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu
            2580                2585                2590        
Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val
        2595                2600                2605            
Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala
    2610                2615                2620                
His Thr Asp Val Tyr His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu
2625                2630                2635                2640
Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu
                2645                2650                2655    
Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn
            2660                2665                2670        
Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His
        2675                2680                2685            
Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu
    2690                2695                2700                
Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys
2705                2710                2715                2720
Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu
                2725                2730                2735    
Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu
            2740                2745                2750        
Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu
        2755                2760                2765            
Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln
    2770                2775                2780                
Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala
2785                2790                2795                2800
Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu
                2805                2810                2815    
Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val
            2820                2825                2830        
Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu
        2835                2840                2845            
Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro
    2850                2855                2860                
Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr
2865                2870                2875                2880
Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp
                2885                2890                2895    
Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val
            2900                2905                2910        
Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His
        2915                2920                2925            
Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro
    2930                2935                2940                
Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp
2945                2950                2955                2960
Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn
                2965                2970                2975    
Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu
            2980                2985                2990        
Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp
        2995                3000                3005            
Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile
    3010                3015                3020                
Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln
3025                3030                3035                3040
Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu
                3045                3050                3055    
Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg
            3060                3065                3070        
Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu
        3075                3080                3085            
Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly
    3090                3095                3100                
Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln
3105                3110                3115                3120
Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile
                3125                3130                3135    
Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu
            3140                3145                3150        
Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser
        3155                3160                3165            
Met Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala
    3170                3175                3180                
Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly
3185                3190                3195                3200
Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser
                3205                3210                3215    
Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro
            3220                3225                3230        
Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp
        3235                3240                3245            
Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala
    3250                3255                3260                
Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly
3265                3270                3275                3280
Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp
                3285                3290                3295    
Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser
            3300                3305                3310        
Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn
        3315                3320                3325            
Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp
    3330                3335                3340                
Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser
3345                3350                3355                3360
Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu
                3365                3370                3375    
Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu
            3380                3385                3390        
Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His
        3395                3400                3405            
Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro
    3410                3415                3420                
Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys
3425                3430                3435                3440
Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu
                3445                3450                3455    
Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln
            3460                3465                3470        
Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val
        3475                3480                3485            
Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met
    3490                3495                3500                
Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu
3505                3510                3515                3520
Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val
                3525                3530                3535    
Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr
            3540                3545                3550        
Pro Gly Lys Pro Met Arg Glu Asp Thr Met
        3555                3560        


<210> 7465
<211> 500
<212> PRT
<213> Homo sapiens

<400> 7465
Met Ala Gly Gly Gly Gly Ser Ser Asp Gly Ser Gly Arg Ala Ala Gly
 1               5                  10                  15      
Arg Arg Ala Ser Arg Ser Ser Gly Arg Ala Arg Arg Gly Arg His Glu
            20                  25                  30          
Pro Gly Leu Gly Gly Pro Ala Glu Arg Gly Ala Gly Glu Ala Arg Leu
        35                  40                  45              
Glu Glu Ala Val Asn Arg Trp Val Leu Lys Phe Tyr Phe His Glu Ala
    50                  55                  60                  
Leu Arg Ala Phe Arg Gly Ser Arg Tyr Gly Asp Phe Arg Gln Ile Arg
65                  70                  75                  80  
Asp Ile Met Gln Ala Leu Leu Val Arg Pro Leu Gly Lys Glu His Thr
                85                  90                  95      
Val Ser Arg Leu Leu Arg Val Met Gln Cys Leu Ser Arg Ile Glu Glu
            100                 105                 110         
Gly Glu Asn Leu Asp Cys Ser Phe Asp Met Glu Ala Glu Leu Thr Pro
        115                 120                 125             
Leu Glu Ser Ala Ile Asn Val Leu Glu Met Ile Lys Thr Glu Phe Thr
    130                 135                 140                 
Leu Thr Glu Ala Val Val Glu Ser Ser Arg Lys Leu Val Lys Glu Ala
145                 150                 155                 160 
Ala Val Ile Ile Cys Ile Lys Asn Lys Glu Phe Glu Lys Ala Ser Lys
                165                 170                 175     
Ile Leu Lys Lys His Met Ser Lys Asp Pro Thr Thr Gln Lys Leu Arg
            180                 185                 190         
Asn Asp Leu Leu Asn Ile Ile Arg Glu Lys Asn Leu Ala His Pro Val
        195                 200                 205             
Ile Gln Asn Phe Ser Tyr Glu Thr Phe Gln Gln Lys Met Leu Arg Phe
    210                 215                 220                 
Leu Glu Ser His Leu Asp Asp Ala Glu Pro Tyr Leu Leu Thr Met Ala
225                 230                 235                 240 
Lys Lys Ala Leu Lys Ser Glu Ser Ala Ala Ser Ser Thr Gly Lys Glu
                245                 250                 255     
Asp Lys Gln Pro Ala Pro Gly Pro Val Glu Lys Pro Pro Arg Glu Pro
            260                 265                 270         
Ala Arg Gln Leu Arg Asn Pro Pro Thr Thr Ile Gly Met Met Thr Leu
        275                 280                 285             
Lys Ala Ala Phe Lys Thr Leu Ser Gly Ala Gln Asp Ser Glu Ala Ala
    290                 295                 300                 
Phe Ala Lys Leu Asp Gln Lys Asp Leu Val Leu Pro Thr Gln Ala Leu
305                 310                 315                 320 
Pro Ala Ser Pro Ala Leu Lys Asn Lys Arg Pro Arg Lys Asp Glu Asn
                325                 330                 335     
Glu Ser Ser Ala Pro Ala Asp Gly Glu Gly Gly Ser Glu Leu Gln Pro
            340                 345                 350         
Lys Asn Lys Arg Met Thr Ile Ser Arg Leu Val Leu Glu Glu Asp Ser
        355                 360                 365             
Gln Ser Thr Glu Pro Ser Ala Gly Leu Asn Ser Ser Gln Glu Ala Ala
    370                 375                 380                 
Ser Ala Pro Pro Ser Lys Pro Thr Val Leu Asn Gln Pro Leu Pro Gly
385                 390                 395                 400 
Glu Lys Asn Pro Lys Val Pro Lys Gly Lys Trp Asn Ser Ser Asn Gly
                405                 410                 415     
Val Glu Glu Lys Glu Thr Trp Val Glu Glu Asp Glu Leu Phe Gln Val
            420                 425                 430         
Gln Ala Ala Pro Asp Glu Asp Ser Thr Thr Asn Ile Thr Lys Lys Gln
        435                 440                 445             
Lys Trp Thr Val Glu Glu Ser Glu Trp Val Lys Ala Gly Val Gln Lys
    450                 455                 460                 
Tyr Gly Glu Gly Asn Trp Ala Ala Ile Ser Lys Asn Tyr Pro Phe Val
465                 470                 475                 480 
Asn Arg Thr Ala Val Met Ile Lys Asp Arg Trp Arg Thr Met Lys Arg
                485                 490                 495     
Leu Gly Met Asn
            500 


<210> 7466
<211> 367
<212> PRT
<213> Homo sapiens

<400> 7466
Met Ala Asp Phe Gly Ile Ser Ala Gly Gln Phe Val Ala Val Val Trp
 1               5                  10                  15      
Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu
            20                  25                  30          
Gln Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn Ile Lys
        35                  40                  45              
Gln Leu Leu Gln Cys Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala
    50                  55                  60                  
Glu Ile Leu Ala Glu Ile Ala Arg Ile Leu Arg Pro Gly Gly Cys Leu
65                  70                  75                  80  
Phe Leu Lys Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val
                85                  90                  95      
Lys Thr Ala Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val
            100                 105                 110         
Glu Val Lys Glu Leu Gln Arg Glu Pro Leu Thr Pro Glu Glu Val Gln
        115                 120                 125             
Ser Val Arg Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val
    130                 135                 140                 
Gln Ile Thr Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gln
145                 150                 155                 160 
Leu Lys Leu Ser Ile Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala
                165                 170                 175     
Val Asp Pro Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met
            180                 185                 190         
Glu Asp Asp Ser Met Cys Ile Phe Cys Gly Cys Ser Leu Thr His Arg
        195                 200                 205             
Trp Pro Leu Glu His Val Val Arg Leu Asn Met Met Ile Asn Gln Lys
    210                 215                 220                 
Glu Asp Arg Val Asp Thr Phe Phe Thr Leu Asp Ser Lys Phe Pro Leu
225                 230                 235                 240 
Glu Ala Cys Ser His Phe Ser Phe Ser Leu Ala Glu Thr Thr Thr Val
                245                 250                 255     
Ser Leu Ile Ala Leu Asn Thr Leu Gln Asp Leu Ile Asp Ser Asp Glu
            260                 265                 270         
Leu Leu Asp Pro Glu Asp Leu Lys Lys Pro Asp Pro Ala Ser Leu Arg
        275                 280                 285             
Ala Ala Ser Cys Gly Glu Gly Lys Lys Arg Lys Ala Cys Lys Asn Cys
    290                 295                 300                 
Thr Cys Gly Leu Ala Glu Glu Leu Glu Lys Glu Lys Ser Arg Glu Gln
305                 310                 315                 320 
Met Ser Ser Gln Pro Lys Ser Ala Cys Gly Asn Cys Tyr Leu Gly Asp
                325                 330                 335     
Ala Phe Arg Cys Ala Ser Cys Pro Tyr Leu Gly Met Pro Ala Phe Lys
            340                 345                 350         
Pro Gly Glu Lys Val Leu Leu Ser Asp Ser Asn Leu His Asp Ala
        355                 360                 365         


<210> 7467
<211> 312
<212> PRT
<213> Homo sapiens

<400> 7467
Met Ala Asp Phe Gly Ile Ser Ala Gly Gln Phe Val Ala Val Val Trp
 1               5                  10                  15      
Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu
            20                  25                  30          
Gln Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn Ile Lys
        35                  40                  45              
Gln Leu Leu Gln Ser Ala His Lys Glu Ser Ser Phe Asp Ile Ile Leu
    50                  55                  60                  
Ser Gly Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala Glu Ile Leu
65                  70                  75                  80  
Ala Glu Ile Ala Arg Ile Leu Arg Pro Gly Gly Cys Leu Phe Leu Lys
                85                  90                  95      
Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val Lys Thr Ala
            100                 105                 110         
Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val Glu Val Lys
        115                 120                 125             
Glu Leu Gln Arg Glu Pro Leu Thr Pro Glu Glu Val Gln Ser Val Arg
    130                 135                 140                 
Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val Gln Ile Thr
145                 150                 155                 160 
Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gln Leu Lys Leu
                165                 170                 175     
Ser Ile Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala Val Asp Pro
            180                 185                 190         
Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met Glu Asp Asp
        195                 200                 205             
Ser Met Asp Leu Ile Asp Ser Asp Glu Leu Leu Asp Pro Glu Asp Leu
    210                 215                 220                 
Lys Lys Pro Asp Pro Ala Ser Leu Arg Ala Ala Ser Cys Gly Glu Gly
225                 230                 235                 240 
Lys Lys Arg Lys Ala Cys Lys Asn Cys Thr Cys Gly Leu Ala Glu Glu
                245                 250                 255     
Leu Glu Lys Glu Lys Ser Arg Glu Gln Met Ser Ser Gln Pro Lys Ser
            260                 265                 270         
Ala Cys Gly Asn Cys Tyr Leu Gly Asp Ala Phe Arg Cys Ala Ser Cys
        275                 280                 285             
Pro Tyr Leu Gly Met Pro Ala Phe Lys Pro Gly Glu Lys Val Leu Leu
    290                 295                 300                 
Ser Asp Ser Asn Leu His Asp Ala
305                 310         


<210> 7468
<211> 541
<212> PRT
<213> Homo sapiens

<400> 7468
Met Ala Ser Gln Glu Phe Glu Val Glu Ala Ile Val Asp Lys Arg Gln
 1               5                  10                  15      
Asp Lys Asn Gly Asn Thr Gln Tyr Leu Val Arg Trp Lys Gly Tyr Asp
            20                  25                  30          
Lys Gln Asp Asp Thr Trp Glu Pro Glu Gln His Leu Met Asn Cys Glu
        35                  40                  45              
Lys Cys Val His Asp Phe Asn Arg Arg Gln Thr Glu Lys Gln Lys Lys
    50                  55                  60                  
Leu Thr Trp Thr Thr Thr Ser Arg Ile Phe Ser Asn Asn Ala Arg Arg
65                  70                  75                  80  
Arg Thr Ser Arg Ser Thr Lys Ala Asn Tyr Ser Lys Asn Ser Pro Lys
                85                  90                  95      
Thr Pro Val Thr Asp Lys His His Arg Ser Lys Asn Cys Lys Leu Phe
            100                 105                 110         
Ala Ala Ser Lys Asn Val Arg Arg Lys Ala Ala Ser Thr Leu Ser Asp
        115                 120                 125             
Thr Lys Asn Met Glu Ile Ile Asn Ser Thr Ile Glu Thr Leu Ala Pro
    130                 135                 140                 
Asp Ser Pro Phe Asp His Lys Lys Thr Val Ser Gly Phe Gln Lys Leu
145                 150                 155                 160 
Glu Lys Leu Asp Pro Ile Ala Ala Asp Gln Gln Asp Thr Val Val Phe
                165                 170                 175     
Lys Val Thr Glu Gly Lys Leu Leu Arg Asp Pro Leu Ser His Pro Gly
            180                 185                 190         
Ala Glu Gln Thr Gly Ile Gln Asn Lys Thr Gln Met His Pro Leu Met
        195                 200                 205             
Ser Gln Met Ser Gly Ser Val Thr Ala Ser Met Ala Thr Gly Ser Ala
    210                 215                 220                 
Thr Arg Lys Gly Ile Val Val Leu Ile Asp Pro Leu Ala Ala Asn Gly
225                 230                 235                 240 
Thr Thr Asp Met His Thr Ser Val Pro Arg Val Lys Gly Gly Gln Arg
                245                 250                 255     
Asn Ile Thr Asp Asp Ser Arg Gly Gln Pro Phe Ile Lys Lys Met His
            260                 265                 270         
Phe Thr Ile Arg Leu Thr Glu Ser Ala Ile Thr Tyr Arg Asp Ile Val
        275                 280                 285             
Val Lys Lys Glu Asp Gly Phe Thr Gln Ile Val Leu Ser Thr Arg Ser
    290                 295                 300                 
Thr Glu Lys Asn Ala Leu Asn Thr Glu Val Ile Lys Glu Met Val Asn
305                 310                 315                 320 
Ala Leu Asn Ser Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Phe Ser
                325                 330                 335     
Ala Ala Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Gly Tyr Phe Val
            340                 345                 350         
Arg His Leu Arg Asn Asp Arg Asn Thr Ala Ser Leu Glu Met Val Asp
        355                 360                 365             
Thr Ile Lys Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile
    370                 375                 380                 
Val Val Ser Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu
385                 390                 395                 400 
Pro Leu Cys Asp Leu Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr
                405                 410                 415     
Pro Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Ser Ile Thr
            420                 425                 430         
Phe Pro Lys Met Met Gly Lys Ala Ser Ala Asn Glu Met Leu Ile Ala
        435                 440                 445             
Gly Arg Lys Leu Thr Ala Arg Glu Ala Cys Ala Lys Gly Leu Val Ser
    450                 455                 460                 
Gln Val Phe Leu Thr Gly Thr Phe Thr Gln Glu Val Met Ile Gln Ile
465                 470                 475                 480 
Lys Glu Leu Ala Ser Tyr Asn Ala Ile Val Leu Glu Glu Cys Lys Ala
                485                 490                 495     
Leu Val Arg Cys Asn Ile Lys Leu Glu Leu Glu Gln Ala Asn Glu Arg
            500                 505                 510         
Glu Cys Glu Val Leu Arg Lys Ile Trp Ser Ser Ala Gln Gly Ile Glu
        515                 520                 525             
Ser Met Leu Lys Tyr Val Glu Asn Lys Ile Asp Glu Phe
    530                 535                 540     


<210> 7469
<211> 595
<212> PRT
<213> Homo sapiens

<400> 7469
Met Ala Ser Gln Glu Phe Glu Val Glu Ala Ile Val Asp Lys Arg Gln
 1               5                  10                  15      
Asp Lys Asn Gly Asn Thr Gln Tyr Leu Val Arg Trp Lys Gly Tyr Asp
            20                  25                  30          
Lys Gln Asp Asp Thr Trp Glu Pro Glu Gln His Leu Met Asn Cys Glu
        35                  40                  45              
Lys Cys Val His Asp Phe Asn Arg Arg Gln Thr Glu Lys Gln Lys Lys
    50                  55                  60                  
Leu Thr Trp Thr Thr Thr Ser Arg Ile Phe Ser Asn Asn Ala Arg Arg
65                  70                  75                  80  
Arg Thr Ser Arg Ser Thr Lys Ala Asn Tyr Ser Lys Asn Ser Pro Lys
                85                  90                  95      
Thr Pro Val Thr Asp Lys His His Arg Ser Lys Asn Cys Lys Leu Phe
            100                 105                 110         
Ala Ala Ser Lys Asn Val Arg Arg Lys Ala Ala Ser Thr Leu Ser Asp
        115                 120                 125             
Thr Lys Asn Met Glu Ile Ile Asn Ser Thr Ile Glu Thr Leu Ala Pro
    130                 135                 140                 
Asp Ser Pro Phe Asp His Lys Lys Thr Val Ser Gly Phe Gln Lys Leu
145                 150                 155                 160 
Glu Lys Leu Asp Pro Ile Ala Ala Asp Gln Gln Asp Thr Val Val Phe
                165                 170                 175     
Lys Val Thr Glu Gly Lys Leu Leu Arg Asp Pro Leu Ser His Pro Gly
            180                 185                 190         
Ala Glu Gln Thr Gly Ile Gln Asn Lys Thr Gln Met His Pro Leu Met
        195                 200                 205             
Ser Gln Met Ser Gly Ser Val Thr Ala Ser Met Ala Thr Gly Ser Ala
    210                 215                 220                 
Thr Arg Lys Gly Ile Val Val Leu Ile Asp Pro Leu Ala Ala Asn Gly
225                 230                 235                 240 
Thr Thr Asp Met His Thr Ser Val Pro Arg Val Lys Gly Gly Gln Arg
                245                 250                 255     
Asn Ile Thr Asp Asp Ser Arg Gly Gln Pro Phe Ile Lys Lys Met His
            260                 265                 270         
Phe Thr Ile Arg Leu Thr Glu Ser Ala Ile Thr Tyr Arg Asp Ile Val
        275                 280                 285             
Val Lys Lys Glu Asp Gly Phe Thr Gln Ile Val Leu Ser Thr Arg Ser
    290                 295                 300                 
Thr Glu Lys Asn Ala Leu Asn Thr Glu Val Ile Lys Glu Met Val Asn
305                 310                 315                 320 
Ala Leu Asn Ser Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Phe Ser
                325                 330                 335     
Ala Ala Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Gly Tyr Phe Val
            340                 345                 350         
Arg His Leu Arg Asn Asp Arg Asn Thr Ala Ser Leu Glu Met Val Asp
        355                 360                 365             
Thr Ile Lys Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile
    370                 375                 380                 
Val Val Ser Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu
385                 390                 395                 400 
Pro Leu Cys Asp Leu Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr
                405                 410                 415     
Pro Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Ser Ile Thr
            420                 425                 430         
Phe Pro Lys Met Met Gly Lys Ala Ser Ala Asn Glu Met Leu Ile Ala
        435                 440                 445             
Gly Arg Lys Leu Thr Ala Arg Glu Ala Cys Ala Lys Gly Leu Val Ser
    450                 455                 460                 
Gln Val Phe Leu Thr Gly Thr Phe Thr Gln Glu Val Met Ile Gln Ile
465                 470                 475                 480 
Lys Glu Leu Ala Ser Tyr Asn Ala Ile Val Leu Glu Glu Cys Lys Ala
                485                 490                 495     
Leu Val Arg Cys Asn Ile Lys Leu Glu Leu Glu Gln Ala Asn Glu Arg
            500                 505                 510         
Glu Cys Glu Val Leu Arg Lys Ile Trp Ser Ser Ala Gln Gly Ile Glu
        515                 520                 525             
Ser Met Leu Lys Ile Pro Leu Leu Gly Tyr Lys Ala Ala Leu Ala Ser
    530                 535                 540                 
Leu Pro Glu Arg His Arg Thr Ile Arg Asp Gly Ala Leu Asp Phe Ile
545                 550                 555                 560 
Val Ala Gln Thr Leu Gln Arg His Thr Ile Ile Arg Asp Leu Ser Phe
                565                 570                 575     
Ser Ile Asn Thr Tyr Gly Thr Lys Ser Thr Asp Asp His Ser Pro Lys
            580                 585                 590         
Leu Asn Thr
        595 


<210> 7470
<211> 1144
<212> PRT
<213> Homo sapiens

<400> 7470
Met Pro Pro Asn Thr Thr Glu Lys Ala Ile Thr Gln Leu Phe Pro Gly
 1               5                  10                  15      
His Ile Tyr Arg Phe Leu Leu Phe Ala Ile Asn Glu Trp Glu Ala Lys
            20                  25                  30          
Thr Thr Leu Ser Pro Ile Phe Thr Val Glu Thr Arg Pro Leu Ser Ala
        35                  40                  45              
Gln Asn Phe Arg Val Thr His Val Thr Ile Thr Glu Val Phe Leu His
    50                  55                  60                  
Trp Asp Pro Pro Asp Pro Val Phe Phe His His Tyr Leu Ile Thr Ile
65                  70                  75                  80  
Leu Asp Val Glu Asn Asn Thr Ser Glu Glu Val Leu Val Glu Lys Arg
                85                  90                  95      
Asn Thr Ala Thr Ile Val Gly Asp Leu Lys Ser Phe His His Tyr Leu
            100                 105                 110         
Val Tyr Leu Phe Ser Val Ala Glu Arg Gly Thr Leu Ser Cys Leu Glu
        115                 120                 125             
Lys Pro Leu Ser Val Ile Thr Glu Pro Lys Pro Val Trp Ile Val Ile
    130                 135                 140                 
Pro Tyr Glu Ser His Ser Thr Ser Val Ile Leu Phe Val Gln Met Pro
145                 150                 155                 160 
Asn Val Glu Val Phe Asp Gly Leu His Ile Val Ile Glu Gly Gly Ala
                165                 170                 175     
Asn Val Thr Met Ala Leu His His Gly Leu Glu Ala Pro Leu Asn Ile
            180                 185                 190         
His Glu Gly Lys Val Thr Asp Ser Ser Ile Asp Ile Leu Trp Asn Arg
        195                 200                 205             
Val Asp Gly Asn Phe Gln His Tyr Glu Ile Thr Cys Ile Asn Tyr Ala
    210                 215                 220                 
Ala Ala Phe Met Val Gln Lys Val Val Gln Glu Thr Ala Ile Phe Ser
225                 230                 235                 240 
Asn Leu Asp Pro Ala Thr Val Tyr Thr Phe Ser Ile Arg Ala Glu Lys
                245                 250                 255     
Glu Gly Phe Lys Asp Ile Thr Ala Asn Ile Lys Glu Ile Gln Thr Gly
            260                 265                 270         
Tyr Arg Leu Cys Arg His Leu Arg Ser Phe Phe His Val Gln Ile Phe
        275                 280                 285             
Pro Trp Ser Phe Lys Gly Arg Leu Ile Ser Tyr Cys Met Pro Ser Arg
    290                 295                 300                 
Gln Glu Lys Leu Ile Lys Val Ile Val Tyr Gly Asn Lys Ala Lys Val
305                 310                 315                 320 
Lys Lys Leu Thr Leu Gly Met Asp Tyr Met Phe Gln Val Lys Lys Val
                325                 330                 335     
Lys Gly Lys Gly Tyr Ser Val Ser Val Met Lys Lys Val Pro Ile Lys
            340                 345                 350         
Pro Glu Gln Pro Glu Lys Leu Arg Ala Phe Asn Ile Ser Thr His Ser
        355                 360                 365             
Phe Ser Leu His Trp Ser Leu Pro Ser Gly His Val Glu Arg Tyr Gln
    370                 375                 380                 
Val Asp Leu Val Pro Asp Ser Gly Phe Val Thr Ile Arg Asp Leu Gly
385                 390                 395                 400 
Gly Gly Glu Tyr Gln Val Asp Val Ser Asn Val Val Pro Gly Thr Arg
                405                 410                 415     
Tyr Asp Ile Thr Ile Ser Ser Ile Ser Thr Thr Tyr Thr Ser Pro Val
            420                 425                 430         
Thr Arg Ile Val Thr Thr Asn Val Thr Met Pro Glu Gly Pro Pro Gln
        435                 440                 445             
Asn Cys Val Thr Gly Asn Ile Thr Gly Lys Ser Phe Ser Ile Leu Trp
    450                 455                 460                 
Asp Pro Pro Thr Ile Val Thr Gly Lys Phe Ser Tyr Arg Val Glu Leu
465                 470                 475                 480 
Tyr Gly Pro Ser Gly Arg Ile Leu Asp Asn Ser Thr Lys Asp Leu Lys
                485                 490                 495     
Phe Ala Phe Thr Asn Leu Thr Pro Phe Thr Met Tyr Asp Val Tyr Ile
            500                 505                 510         
Ala Ala Glu Thr Ser Ala Gly Thr Gly Pro Lys Ser Asn Ile Ser Val
        515                 520                 525             
Phe Thr Pro Pro Asp Val Pro Gly Ala Val Phe Asp Leu Gln Leu Ala
    530                 535                 540                 
Glu Val Glu Ser Thr Gln Val Arg Ile Thr Trp Lys Lys Pro Arg Gln
545                 550                 555                 560 
Pro Asn Gly Ile Ile Asn Gln Tyr Arg Val Lys Val Leu Val Pro Glu
                565                 570                 575     
Thr Gly Ile Ile Leu Glu Asn Thr Leu Leu Thr Gly Asn Asn Glu Leu
            580                 585                 590         
Ser Glu Asn Leu Met Gln Gln Met Glu Met Pro His Arg Gln Lys Leu
        595                 600                 605             
Ala Pro Pro Asn Pro Phe Asp Leu Leu Pro Gly Glu Ser Ser Thr Leu
    610                 615                 620                 
Glu Ser Leu Ala Lys Leu His Arg Gln Ser Val Ile Thr Val Ala Lys
625                 630                 635                 640 
Ala Val Thr Thr Arg Asn Gln Tyr Ile Thr Asp Ile Ala Ala Glu Gln
                645                 650                 655     
Leu Ser Tyr Val Ile Arg Arg Leu Val Pro Phe Thr Glu His Met Ile
            660                 665                 670         
Ser Val Ser Ala Phe Thr Ile Met Gly Glu Gly Pro Pro Thr Val Leu
        675                 680                 685             
Ser Val Arg Thr Arg Gln Gln Gly Leu Lys Lys Tyr Thr Lys Tyr Lys
    690                 695                 700                 
Met Arg Val Ala Ala Ser Thr His Val Gly Glu Ser Ser Leu Ser Glu
705                 710                 715                 720 
Glu Asn Asp Ile Phe Val Arg Thr Ser Glu Asp Glu Pro Glu Ser Ser
                725                 730                 735     
Pro Gln Asp Val Glu Val Ile Asp Val Thr Ala Asp Glu Ile Arg Leu
            740                 745                 750         
Lys Trp Ser Pro Pro Glu Lys Pro Asn Gly Ile Ile Ile Ala Tyr Glu
        755                 760                 765             
Val Leu Tyr Lys Asn Ile Asp Thr Leu Tyr Met Lys Asn Thr Ser Thr
    770                 775                 780                 
Thr Asp Ile Ile Leu Arg Asn Leu Arg Pro His Thr Leu Tyr Asn Ile
785                 790                 795                 800 
Ser Val Arg Ser Tyr Thr Arg Phe Gly His Gly Asn Gln Val Ser Ser
                805                 810                 815     
Leu Leu Ser Val Arg Thr Ser Glu Thr Val Leu Lys Lys Tyr Thr Gln
            820                 825                 830         
Tyr Ile Ile Glu Val Ser Ala Ser Thr Leu Lys Gly Glu Gly Val Arg
        835                 840                 845             
Ser Ala Pro Ile Ser Ile Leu Thr Glu Glu Asp Ala Pro Asp Ser Pro
    850                 855                 860                 
Pro Gln Asp Phe Ser Val Lys Gln Leu Ser Gly Val Thr Val Lys Leu
865                 870                 875                 880 
Ser Trp Gln Pro Pro Leu Glu Pro Asn Gly Ile Ile Leu Tyr Tyr Thr
                885                 890                 895     
Val Tyr Val Trp Asn Arg Ser Ser Leu Lys Thr Ile Asn Val Thr Glu
            900                 905                 910         
Thr Ser Leu Glu Leu Ser Asp Leu Asp Tyr Asn Val Glu Tyr Ser Ala
        915                 920                 925             
Tyr Val Thr Ala Ser Thr Arg Phe Gly Asp Gly Lys Thr Arg Ser Asn
    930                 935                 940                 
Ile Ile Ser Phe Gln Thr Pro Glu Gly Val Pro Glu Thr Ser Pro Ile
945                 950                 955                 960 
Ile Asn Thr Phe Lys Asn Leu Ser Ser Thr Ser Val Leu Leu Ser Trp
                965                 970                 975     
Asp Pro Pro Val Lys Pro Asn Gly Ala Ile Ile Ser Tyr Asp Leu Thr
            980                 985                 990         
Leu Gln Gly Pro Asn Glu Asn Tyr Ser Phe Ile Thr Ser Asp Asn Tyr
        995                 1000                1005            
Ile Ile Leu Glu Glu Leu Ser Pro Phe Thr Leu Tyr Ser Phe Phe Ala
    1010                1015                1020                
Ala Ala Arg Thr Arg Lys Gly Leu Gly Pro Ser Ser Ile Leu Phe Phe
1025                1030                1035                1040
Tyr Thr Asp Glu Ser Val Pro Leu Ala Pro Pro Gln Asn Leu Thr Leu
                1045                1050                1055    
Ile Asn Cys Thr Ser Asp Phe Val Trp Leu Lys Trp Ser Pro Ser Pro
            1060                1065                1070        
Leu Pro Gly Gly Ile Val Lys Val Tyr Ser Phe Lys Ile His Glu His
        1075                1080                1085            
Glu Thr Asp Thr Ile Tyr Tyr Lys Asn Ile Ser Gly Phe Lys Thr Glu
    1090                1095                1100                
Ala Lys Leu Val Gly Leu Glu Pro Val Ser Thr Tyr Ser Ile Arg Val
1105                1110                1115                1120
Ser Ala Phe Thr Lys Val Gly Asn Gly Asn Gln Phe Ser Asn Val Val
                1125                1130                1135    
Lys Phe Thr Thr Gln Glu Ser Gly
            1140                


<210> 7471
<211> 303
<212> PRT
<213> Homo sapiens

<400> 7471
Met Val Ala Pro Arg Pro Leu Arg Arg Val Val Leu Phe Tyr Gln Gly
 1               5                  10                  15      
Lys Leu Cys Ser Met Ala Gly Asn Phe Trp Gln Ser Ser His Tyr Leu
            20                  25                  30          
Gln Trp Ile Leu Asp Lys Gln Asp Leu Leu Lys Glu Arg Gln Lys Asp
        35                  40                  45              
Leu Lys Phe Leu Ser Glu Glu Glu Tyr Trp Lys Leu Gln Ile Phe Phe
    50                  55                  60                  
Thr Asn Val Ile Gln Ala Leu Gly Glu His Leu Lys Leu Arg Gln Gln
65                  70                  75                  80  
Val Ile Ala Thr Ala Thr Val Tyr Phe Lys Arg Phe Tyr Ala Arg Tyr
                85                  90                  95      
Ser Leu Lys Ser Ile Asp Pro Val Leu Met Ala Pro Thr Cys Val Phe
            100                 105                 110         
Leu Ala Ser Lys Val Glu Glu Phe Gly Val Val Ser Asn Thr Arg Leu
        115                 120                 125             
Ile Ala Ala Ala Thr Ser Val Leu Lys Thr Arg Phe Ser Tyr Ala Phe
    130                 135                 140                 
Pro Lys Glu Phe Pro Tyr Arg Met Asn His Ile Leu Glu Cys Glu Phe
145                 150                 155                 160 
Tyr Leu Leu Glu Leu Met Asp Cys Cys Leu Ile Val Tyr His Pro Tyr
                165                 170                 175     
Arg Pro Leu Leu Gln Tyr Val Gln Asp Met Gly Gln Glu Asp Met Leu
            180                 185                 190         
Leu Pro Leu Ala Trp Arg Ile Val Asn Asp Thr Tyr Arg Thr Asp Leu
        195                 200                 205             
Cys Leu Leu Tyr Pro Pro Phe Met Ile Ala Leu Ala Cys Leu His Val
    210                 215                 220                 
Ala Cys Val Val Gln Gln Lys Asp Ala Arg Gln Trp Phe Ala Glu Leu
225                 230                 235                 240 
Ser Val Asp Met Glu Lys Ile Leu Glu Ile Ile Arg Val Ile Leu Lys
                245                 250                 255     
Leu Tyr Glu Gln Trp Lys Asn Phe Asp Glu Arg Lys Glu Met Ala Thr
            260                 265                 270         
Ile Leu Ser Lys Met Pro Lys Pro Lys Pro Pro Pro Asn Ser Glu Gly
        275                 280                 285             
Glu Gln Gly Pro Asn Gly Ser Gln Asn Ser Ser Tyr Ser Gln Ser
    290                 295                 300             


<210> 7472
<211> 637
<212> PRT
<213> Homo sapiens

<400> 7472
Met Leu Gly Lys Gly Val Val Gly Gly Gly Gly Gly Thr Lys Ala Pro
 1               5                  10                  15      
Lys Pro Ser Phe Val Ser Tyr Val Arg Pro Glu Glu Ile His Thr Asn
            20                  25                  30          
Glu Lys Glu Val Thr Glu Lys Glu Val Thr Leu His Leu Leu Pro Gly
        35                  40                  45              
Glu Gln Leu Leu Cys Glu Ala Ser Thr Val Leu Lys Tyr Val Gln Glu
    50                  55                  60                  
Asp Ser Cys Gln His Gly Val Tyr Gly Arg Leu Val Cys Thr Asp Phe
65                  70                  75                  80  
Lys Ile Ala Phe Leu Gly Asp Asp Glu Ser Ala Leu Asp Asn Asp Glu
                85                  90                  95      
Thr Gln Phe Lys Asn Lys Val Ile Gly Glu Asn Asp Ile Thr Leu His
            100                 105                 110         
Cys Val Asp Gln Ile Tyr Gly Val Phe Asp Glu Lys Lys Lys Thr Leu
        115                 120                 125             
Phe Gly Gln Leu Lys Lys Tyr Pro Glu Lys Leu Ile Ile His Cys Lys
    130                 135                 140                 
Asp Leu Arg Val Phe Gln Phe Cys Leu Arg Tyr Thr Lys Glu Glu Glu
145                 150                 155                 160 
Val Lys Arg Ile Val Ser Gly Ile Ile His His Thr Gln Ala Pro Lys
                165                 170                 175     
Leu Leu Lys Arg Leu Phe Leu Phe Ser Tyr Ala Thr Ala Ala Gln Asn
            180                 185                 190         
Asn Thr Val Thr Val Pro Lys Asn His Thr Val Met Phe Asp Thr Leu
        195                 200                 205             
Lys Asp Trp Cys Trp Glu Leu Glu Arg Thr Lys Gly Asn Met Lys Tyr
    210                 215                 220                 
Lys Ala Val Ser Val Asn Glu Gly Tyr Lys Val Cys Glu Arg Leu Pro
225                 230                 235                 240 
Ala Tyr Phe Val Val Pro Thr Pro Leu Pro Glu Glu Asn Val Gln Arg
                245                 250                 255     
Phe Gln Gly His Gly Ile Pro Ile Trp Cys Trp Ser Cys His Asn Gly
            260                 265                 270         
Ser Ala Leu Leu Lys Met Ser Ala Leu Pro Lys Glu Gln Asp Asp Gly
        275                 280                 285             
Ile Leu Gln Ile Gln Lys Ser Phe Leu Asp Gly Ile Tyr Lys Thr Ile
    290                 295                 300                 
His Arg Pro Pro Tyr Glu Ile Val Lys Thr Glu Asp Leu Ser Ser Asn
305                 310                 315                 320 
Phe Leu Ser Leu Gln Glu Ile Gln Thr Ala Tyr Ser Lys Phe Lys Gln
                325                 330                 335     
Leu Phe Leu Ile Asp Asn Ser Thr Glu Phe Trp Asp Thr Asp Ile Lys
            340                 345                 350         
Trp Phe Ser Leu Leu Glu Ser Ser Ser Trp Leu Asp Ile Ile Arg Arg
        355                 360                 365             
Cys Leu Lys Lys Ala Ile Glu Ile Thr Glu Cys Met Glu Ala Gln Asn
    370                 375                 380                 
Met Asn Val Leu Leu Leu Glu Glu Asn Ala Ser Asp Leu Cys Cys Leu
385                 390                 395                 400 
Ile Ser Ser Leu Val Gln Leu Met Met Asp Pro His Cys Arg Thr Arg
                405                 410                 415     
Ile Gly Phe Gln Ser Leu Ile Gln Lys Glu Trp Val Met Gly Gly His
            420                 425                 430         
Cys Phe Leu Asp Arg Cys Asn His Leu Arg Gln Asn Asp Lys Glu Glu
        435                 440                 445             
His Gln Arg Gln Leu Ser Leu Pro Leu Thr Gln Ser Lys Ser Ser Pro
    450                 455                 460                 
Lys Arg Gly Phe Phe Arg Glu Glu Thr Asp His Leu Ile Lys Asn Leu
465                 470                 475                 480 
Leu Gly Lys Arg Ile Ser Lys Leu Ile Asn Ser Ser Asp Glu Leu Gln
                485                 490                 495     
Asp Asn Phe Arg Glu Phe Tyr Asp Ser Trp His Ser Lys Ser Thr Asp
            500                 505                 510         
Tyr His Gly Leu Leu Leu Pro His Ile Glu Gly Pro Glu Ile Lys Val
        515                 520                 525             
Trp Ala Gln Arg Tyr Leu Arg Trp Ile Pro Glu Ala Gln Ile Leu Gly
    530                 535                 540                 
Gly Gly Gln Val Ala Thr Leu Ser Lys Leu Leu Glu Met Met Glu Glu
545                 550                 555                 560 
Val Gln Ser Leu Gln Glu Lys Ile Asp Glu Arg His His Ser Gln Gln
                565                 570                 575     
Ala Pro Gln Ala Glu Ala Pro Cys Leu Leu Arg Asn Ser Ala Arg Leu
            580                 585                 590         
Ser Ser Leu Phe Pro Phe Ala Leu Leu Gln Arg His Ser Ser Lys Pro
        595                 600                 605             
Val Leu Pro Thr Ser Gly Trp Lys Ala Leu Gly Asp Glu Asp Asp Leu
    610                 615                 620                 
Ala Lys Arg Glu Asp Glu Phe Val Asp Leu Gly Asp Val
625                 630                 635         


<210> 7473
<211> 775
<212> PRT
<213> Homo sapiens

<400> 7473
Cys Trp Trp Pro Pro Leu Leu Pro Gln Leu Glu Pro Glu Pro Pro Pro
 1               5                  10                  15      
Leu Arg Pro Arg Val Ala Ala Ser Gln Gly Gly Gly Met Leu Gly Lys
            20                  25                  30          
Gly Val Val Gly Gly Gly Gly Gly Thr Lys Ala Pro Lys Pro Ser Phe
        35                  40                  45              
Val Ser Tyr Val Arg Pro Glu Glu Ile His Thr Asn Glu Lys Glu Val
    50                  55                  60                  
Thr Glu Lys Glu Val Thr Leu His Leu Leu Pro Gly Glu Gln Leu Leu
65                  70                  75                  80  
Cys Glu Ala Ser Thr Val Leu Lys Tyr Val Gln Glu Asp Ser Cys Gln
                85                  90                  95      
His Gly Val Tyr Gly Arg Leu Val Cys Thr Asp Phe Lys Ile Ala Phe
            100                 105                 110         
Leu Gly Asp Asp Glu Ser Ala Leu Asp Asn Asp Glu Thr Gln Phe Lys
        115                 120                 125             
Asn Lys Val Ile Gly Glu Asn Asp Ile Thr Leu His Cys Val Asp Gln
    130                 135                 140                 
Ile Tyr Gly Val Phe Asp Glu Lys Lys Lys Thr Leu Phe Gly Gln Leu
145                 150                 155                 160 
Lys Lys Tyr Pro Glu Lys Leu Ile Ile His Cys Lys Asp Leu Arg Val
                165                 170                 175     
Phe Gln Phe Cys Leu Arg Tyr Thr Lys Glu Glu Glu Val Lys Arg Ile
            180                 185                 190         
Val Ser Gly Ile Ile His His Thr Gln Ala Pro Lys Leu Leu Lys Arg
        195                 200                 205             
Leu Phe Leu Phe Ser Tyr Ala Thr Ala Ala Gln Asn Asn Thr Val Thr
    210                 215                 220                 
Asp Pro Lys Asn His Thr Val Met Phe Asp Thr Leu Lys Asp Trp Cys
225                 230                 235                 240 
Trp Glu Leu Glu Arg Thr Lys Gly Asn Met Lys Tyr Lys Ala Val Ser
                245                 250                 255     
Val Asn Glu Gly Tyr Lys Val Cys Glu Arg Leu Pro Ala Tyr Phe Val
            260                 265                 270         
Val Pro Thr Pro Leu Pro Glu Glu Asn Val Gln Arg Phe Gln Gly His
        275                 280                 285             
Gly Ile Pro Ile Trp Cys Trp Ser Cys His Asn Gly Ser Ala Leu Leu
    290                 295                 300                 
Lys Met Ser Ala Leu Pro Lys Glu Gln Asp Asp Gly Ile Leu Gln Ile
305                 310                 315                 320 
Gln Lys Ser Phe Leu Asp Gly Ile Tyr Lys Thr Ile His Arg Pro Pro
                325                 330                 335     
Tyr Glu Ile Val Lys Thr Glu Asp Leu Ser Ser Asn Phe Leu Ser Leu
            340                 345                 350         
Gln Glu Ile Gln Thr Ala Tyr Ser Lys Phe Lys Gln Leu Phe Leu Ile
        355                 360                 365             
Asp Asn Ser Thr Glu Phe Trp Asp Thr Asp Ile Lys Trp Phe Ser Leu
    370                 375                 380                 
Leu Glu Ser Ser Ser Trp Leu Asp Ile Ile Arg Arg Cys Leu Lys Lys
385                 390                 395                 400 
Ala Ile Glu Ile Thr Glu Cys Met Glu Ala Gln Asn Met Asn Val Leu
                405                 410                 415     
Leu Leu Glu Glu Asn Ala Ser Asp Leu Cys Cys Leu Ile Ser Ser Leu
            420                 425                 430         
Val Gln Leu Met Met Asp Pro His Cys Arg Thr Arg Ile Gly Phe Gln
        435                 440                 445             
Ser Leu Ile Gln Lys Glu Trp Val Met Gly Gly His Cys Phe Leu Asp
    450                 455                 460                 
Arg Cys Asn His Leu Arg Gln Asn Asp Lys Glu Glu Val Pro Val Phe
465                 470                 475                 480 
Leu Leu Phe Leu Asp Cys Val Trp Gln Leu Val His Gln His Pro Pro
                485                 490                 495     
Ala Phe Glu Phe Thr Glu Thr Tyr Leu Thr Val Leu Ser Asp Ser Leu
            500                 505                 510         
Tyr Ile Pro Ile Phe Ser Thr Phe Phe Phe Asn Ser Pro His Gln Lys
        515                 520                 525             
Asp Thr Asn Met Gly Arg Glu Gly Gln Asp Thr Gln Ser Lys Pro Leu
    530                 535                 540                 
Asn Leu Leu Thr Val Trp Asp Trp Ser Val Gln Phe Glu Pro Lys Ala
545                 550                 555                 560 
Gln Thr Leu Leu Lys Asn Pro Leu Tyr Val Glu Lys Pro Lys Leu Asp
                565                 570                 575     
Lys Gly Gln Arg Lys Gly Met Arg Phe Lys His Gln Arg Gln Leu Ser
            580                 585                 590         
Leu Pro Leu Thr Gln Ser Lys Ser Ser Pro Lys Arg Gly Phe Phe Arg
        595                 600                 605             
Glu Glu Thr Asp His Leu Ile Lys Asn Leu Leu Gly Lys Arg Ile Ser
    610                 615                 620                 
Lys Leu Ile Asn Ser Ser Asp Glu Leu Gln Asp Asn Phe Arg Glu Phe
625                 630                 635                 640 
Tyr Asp Ser Trp His Ser Lys Ser Thr Asp Tyr His Gly Leu Leu Leu
                645                 650                 655     
Pro His Ile Glu Gly Pro Glu Ile Lys Val Trp Ala Gln Arg Tyr Leu
            660                 665                 670         
Arg Trp Ile Pro Glu Ala Gln Ile Leu Gly Gly Gly Gln Val Ala Thr
        675                 680                 685             
Leu Ser Lys Leu Leu Glu Met Met Glu Glu Val Gln Ser Leu Gln Glu
    690                 695                 700                 
Lys Ile Asp Glu Arg His His Ser Gln Gln Ala Pro Gln Ala Glu Ala
705                 710                 715                 720 
Pro Cys Leu Leu Arg Asn Ser Ala Arg Leu Ser Ser Leu Phe Pro Phe
                725                 730                 735     
Ala Leu Leu Gln Arg His Ser Ser Lys Pro Val Leu Pro Thr Ser Gly
            740                 745                 750         
Trp Lys Ala Leu Gly Asp Glu Asp Asp Leu Ala Lys Arg Glu Asp Glu
        755                 760                 765             
Phe Val Asp Leu Gly Asp Val
    770                 775 


<210> 7474
<211> 705
<212> PRT
<213> Homo sapiens

<400> 7474
Met Leu Arg Glu Glu Ala Ala Gln Lys Arg Lys Gly Lys Glu Pro Gly
 1               5                  10                  15      
Met Ala Leu Pro Gln Gly Arg Leu Thr Phe Arg Asp Val Ala Ile Glu
            20                  25                  30          
Phe Ser Leu Ala Glu Trp Lys Cys Leu Asn Pro Ser Gln Arg Ala Leu
        35                  40                  45              
Tyr Arg Glu Val Met Leu Glu Asn Tyr Arg Asn Leu Glu Ala Val Asp
    50                  55                  60                  
Ile Ser Ser Lys Cys Met Met Lys Glu Val Leu Ser Thr Gly Gln Gly
65                  70                  75                  80  
Asn Thr Glu Val Ile His Thr Gly Thr Leu Gln Arg His Glu Ser His
                85                  90                  95      
His Ile Gly Asp Phe Cys Phe Gln Glu Ile Glu Lys Glu Ile His Asp
            100                 105                 110         
Ile Glu Phe Gln Cys Gln Glu Asp Glu Arg Asp Gly Leu Glu Ala Pro
        115                 120                 125             
Met Thr Lys Ile Lys Lys Leu Thr Gly Ser Thr Asp Gln His Asp His
    130                 135                 140                 
Arg His Ala Gly Asn Lys Pro Ile Lys Asp Gln Leu Gly Ser Ser Phe
145                 150                 155                 160 
Tyr Ser His Leu Pro Glu Leu His Ile Phe Gln Ile Lys Gly Glu Ile
                165                 170                 175     
Gly Asn Gln Leu Glu Lys Ser Thr Asn Asp Ala Pro Ser Val Ser Thr
            180                 185                 190         
Phe Gln Arg Ile Ser Cys Arg Pro Gln Thr Gln Ile Ser Asn Asn Tyr
        195                 200                 205             
Gly Asn Asn Pro Leu Asn Ser Ser Leu Leu Pro Gln Lys Gln Glu Val
    210                 215                 220                 
His Met Arg Glu Lys Ser Phe Gln Cys Asn Lys Ser Gly Lys Ala Phe
225                 230                 235                 240 
Asn Cys Ser Ser Leu Leu Arg Lys His Gln Ile Ile His Leu Gly Asp
                245                 250                 255     
Lys Gln Tyr Lys Cys Asp Val Cys Gly Lys Leu Phe Asn His Glu Gln
            260                 265                 270         
Tyr Leu Ala Cys His Asp Arg Cys His Thr Val Glu Lys Pro Tyr Lys
        275                 280                 285             
Cys Lys Glu Cys Gly Lys Thr Phe Ser Gln Glu Ser Ser Leu Thr Cys
    290                 295                 300                 
His Arg Arg Leu His Thr Gly Val Lys Arg Tyr Asn Cys Asn Glu Cys
305                 310                 315                 320 
Gly Lys Ile Phe Gly Gln Asn Ser Ala Leu Leu Ile Asp Lys Ala Ile
                325                 330                 335     
Asp Thr Gly Glu Asn Pro Tyr Lys Cys Asn Glu Cys Asp Lys Ala Phe
            340                 345                 350         
Asn Gln Gln Ser Gln Leu Ser His His Arg Ile His Thr Gly Glu Lys
        355                 360                 365             
Pro Tyr Lys Cys Glu Glu Cys Asp Lys Val Ser Ser Arg Lys Ser Thr
    370                 375                 380                 
Ile Glu Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys
385                 390                 395                 400 
Lys Val Cys Asp Thr Ala Phe Thr Trp His Ser Gln Leu Ala Arg His
                405                 410                 415     
Arg Arg Ile His Thr Ala Lys Lys Thr Tyr Lys Cys Asn Glu Cys Gly
            420                 425                 430         
Lys Thr Phe Ser His Lys Ser Ser Leu Val Cys His His Arg Leu His
        435                 440                 445             
Gly Gly Glu Lys Ser Tyr Lys Cys Lys Val Cys Asp Lys Ala Phe Val
    450                 455                 460                 
Trp Ser Ser Gln Leu Ala Lys His Thr Arg Ile Asp Cys Gly Glu Lys
465                 470                 475                 480 
Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Gly Gln Asn Ser Asp
                485                 490                 495     
Leu Leu Ile His Lys Ser Ile His Thr Gly Glu Gln Pro Tyr Lys Cys
            500                 505                 510         
Asp Glu Cys Glu Lys Val Phe Ser Arg Lys Ser Ser Leu Glu Thr His
        515                 520                 525             
Lys Ile Gly His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Val Cys Asp
    530                 535                 540                 
Lys Ala Phe Ala Cys His Ser Tyr Leu Ala Lys His Thr Arg Ile His
545                 550                 555                 560 
Ser Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Ser Lys Thr Phe Ser
                565                 570                 575     
His Arg Ser Tyr Leu Val Cys His His Arg Val His Ser Gly Glu Lys
            580                 585                 590         
Pro Tyr Lys Cys Asn Glu Cys Ser Lys Thr Phe Ser Arg Arg Ser Ser
        595                 600                 605             
Leu His Cys His Arg Arg Leu His Ser Gly Glu Lys Pro Tyr Lys Cys
    610                 615                 620                 
Asn Glu Cys Gly Asn Thr Phe Arg His Cys Ser Ser Leu Ile Tyr His
625                 630                 635                 640 
Arg Arg Leu His Thr Gly Glu Lys Ser Tyr Lys Cys Thr Ile Cys Asp
                645                 650                 655     
Lys Ala Phe Val Arg Asn Ser Leu Leu Ser Arg His Thr Arg Ile His
            660                 665                 670         
Thr Ala Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Asn
        675                 680                 685             
Gln Gln Ser His Leu Ser Arg His His Arg Ile His Thr Gly Glu Lys
    690                 695                 700                 
Pro
705 


<210> 7475
<211> 445
<212> PRT
<213> Homo sapiens

<400> 7475
Met Asn Arg His Leu Cys Val Trp Leu Phe Arg His Pro Ser Leu Asn
 1               5                  10                  15      
Gly Tyr Leu Gln Cys His Ile Gln Leu His Ser His Gln Phe Arg Gln
            20                  25                  30          
Ile His Leu Asp Thr Arg Leu Gln Val Phe Arg Gln Asn Arg Asn Cys
        35                  40                  45              
Ile Leu His Leu Leu Ser Lys Asn Trp Ser Arg Arg Tyr Cys Leu Gln
    50                  55                  60                  
Asp Thr Lys Met Leu Trp Asn His Lys Ala Leu Gln Lys Tyr Met Glu
65                  70                  75                  80  
Asn Leu Ser Lys Glu Tyr Gln Thr Leu Glu Gln Cys Leu Gln His Ile
                85                  90                  95      
Pro Val Asn Glu Glu Ser Arg Arg Ser Leu Asn Arg Arg His Ala Glu
            100                 105                 110         
Leu Ala Pro Leu Ala Ala Ile Tyr Gln Glu Thr Gln Glu Thr Glu Gln
        115                 120                 125             
Ala Ile Glu Glu Leu Gly Ser Met Cys Lys Ser Leu Asn Lys Arg Asp
    130                 135                 140                 
Glu Lys Gln Leu Leu Glu Leu Ala Leu Glu Glu Arg Gln Thr Ile Asp
145                 150                 155                 160 
Gln Lys Ile Asn Met Leu Tyr Asn Glu Leu Phe Gln Ser Leu Val Pro
                165                 170                 175     
Lys Glu Lys Tyr Asp Lys Asn Asp Val Ile Leu Glu Val Thr Ala Gly
            180                 185                 190         
Arg Thr Thr Gly Gly Asp Ile Cys Gln Gln Phe Thr Arg Glu Ile Phe
        195                 200                 205             
Asp Met Tyr Gln Asn Tyr Ser Cys Tyr Lys His Trp Gln Phe Glu Pro
    210                 215                 220                 
Leu Asn Tyr Thr Pro Ala Asp Tyr Gly Gly Leu His His Ala Ala Ala
225                 230                 235                 240 
Arg Ile Ser Gly Asp Gly Val Tyr Lys His Leu Lys Tyr Glu Gly Gly
                245                 250                 255     
Ile His Arg Val Gln Arg Ile Pro Glu Val Gly Leu Ser Ser Arg Met
            260                 265                 270         
Gln Arg Ile His Thr Gly Thr Met Ser Val Ile Val Leu Pro Gln Pro
        275                 280                 285             
Asp Glu Val Asp Val Lys Leu Asp Pro Lys Asp Leu Arg Ile Asp Thr
    290                 295                 300                 
Phe Arg Ala Lys Gly Ala Gly Gly Gln His Val Asn Lys Thr Asp Ser
305                 310                 315                 320 
Ala Val Arg Leu Val His Ile Pro Thr Gly Leu Val Val Glu Cys Gln
                325                 330                 335     
Gln Glu Arg Ser Gln Ile Lys Asn Lys Glu Ile Ala Phe Arg Val Leu
            340                 345                 350         
Arg Ala Arg Leu Tyr Gln Gln Ile Ile Glu Lys Asp Lys Arg Gln Gln
        355                 360                 365             
Gln Ser Ala Arg Lys Leu Gln Val Gly Thr Arg Ala Gln Ser Glu Arg
    370                 375                 380                 
Ile Arg Thr Tyr Asn Phe Thr Gln Asp Arg Val Ser Asp His Arg Ile
385                 390                 395                 400 
Ala Tyr Glu Val Arg Asp Ile Lys Glu Phe Leu Cys Gly Gly Lys Gly
                405                 410                 415     
Leu Asp Gln Leu Ile Gln Arg Leu Leu Gln Ser Ala Asp Glu Glu Ala
            420                 425                 430         
Ile Ala Glu Leu Leu Asp Glu His Leu Lys Ser Ala Lys
        435                 440                 445 


<210> 7476
<211> 445
<212> PRT
<213> Homo sapiens

<400> 7476
Met Asn Arg His Leu Cys Val Trp Leu Phe Arg His Pro Ser Leu Asn
 1               5                  10                  15      
Gly Tyr Leu Gln Cys His Ile Gln Leu His Ser His Gln Phe Arg Gln
            20                  25                  30          
Ile His Leu Asp Thr Arg Leu Gln Val Phe Arg Gln Asn Arg Asn Cys
        35                  40                  45              
Ile Leu His Leu Leu Ser Lys Asn Trp Ser Arg Arg Tyr Cys His Gln
    50                  55                  60                  
Asp Thr Lys Met Leu Trp Lys His Lys Ala Leu Gln Lys Tyr Met Glu
65                  70                  75                  80  
Asn Leu Ser Lys Glu Tyr Gln Thr Leu Glu Gln Cys Leu Gln His Ile
                85                  90                  95      
Pro Val Asn Glu Glu Asn Arg Arg Ser Leu Asn Arg Arg His Ala Glu
            100                 105                 110         
Leu Ala Pro Leu Ala Ala Ile Tyr Gln Glu Ile Gln Glu Thr Glu Gln
        115                 120                 125             
Ala Ile Glu Glu Leu Glu Ser Met Cys Lys Ser Leu Asn Lys Gln Asp
    130                 135                 140                 
Glu Lys Gln Leu Gln Glu Leu Ala Leu Glu Glu Arg Gln Thr Ile Asp
145                 150                 155                 160 
Gln Lys Ile Asn Met Leu Tyr Asn Glu Leu Phe Gln Ser Leu Val Pro
                165                 170                 175     
Lys Glu Lys Tyr Asp Lys Asn Asp Val Ile Leu Glu Val Thr Ala Gly
            180                 185                 190         
Arg Thr Thr Gly Gly Asp Ile Cys Gln Gln Phe Thr Arg Glu Ile Phe
        195                 200                 205             
Asp Met Tyr Gln Asn Tyr Ser Cys Tyr Lys His Trp Gln Phe Glu Leu
    210                 215                 220                 
Leu Asn Tyr Thr Pro Ala Asp Tyr Gly Gly Leu His His Ala Ala Ala
225                 230                 235                 240 
Arg Ile Ser Gly Asp Gly Val Tyr Lys His Leu Lys Tyr Glu Gly Gly
                245                 250                 255     
Ile His Arg Val Gln Arg Ile Pro Glu Val Gly Leu Ser Ser Arg Met
            260                 265                 270         
Gln Arg Ile His Thr Gly Thr Met Ser Val Ile Val Leu Pro Gln Pro
        275                 280                 285             
Asp Glu Val Asp Val Lys Leu Asp Pro Lys Asp Leu Arg Ile Asp Thr
    290                 295                 300                 
Phe Arg Ala Lys Gly Ala Gly Gly Gln His Val Asn Lys Thr Asp Ser
305                 310                 315                 320 
Ala Val Arg Leu Val His Ile Pro Thr Gly Leu Val Val Glu Cys Gln
                325                 330                 335     
Gln Glu Arg Ser Gln Ile Lys Asn Lys Glu Ile Ala Phe Arg Val Leu
            340                 345                 350         
Arg Ala Arg Leu Tyr Gln Gln Ile Ile Glu Lys Asp Lys Arg Gln Gln
        355                 360                 365             
Gln Ser Ala Arg Lys Leu Gln Val Gly Thr Arg Ala Gln Ser Glu Arg
    370                 375                 380                 
Ile Arg Thr Tyr Asn Phe Thr Gln Asp Arg Val Ser Asp His Arg Ile
385                 390                 395                 400 
Ala Tyr Glu Val Arg Asp Ile Lys Glu Phe Leu Cys Gly Gly Lys Gly
                405                 410                 415     
Leu Asp Gln Leu Ile Gln Arg Leu Leu Gln Ser Ala Asp Glu Glu Ala
            420                 425                 430         
Ile Ala Glu Leu Leu Asp Glu His Leu Lys Ser Ala Lys
        435                 440                 445 


<210> 7477
<211> 3433
<212> PRT
<213> Homo sapiens

<400> 7477
Met Ala Lys Tyr Gly Glu His Glu Ala Ser Pro Asp Asn Gly Gln Asn
 1               5                  10                  15      
Glu Phe Ser Asp Ile Ile Lys Ser Arg Ser Asp Glu His Asn Asp Val
            20                  25                  30          
Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Arg Phe Ser Lys Ser
        35                  40                  45              
Gly Lys Pro Pro Ile Asn Asp Met Phe Thr Asp Leu Lys Asp Gly Arg
    50                  55                  60                  
Lys Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Thr Ser Leu Pro Lys
65                  70                  75                  80  
Glu Arg Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Arg Val
                85                  90                  95      
Leu Gln Val Leu His Gln Asn Asn Val Glu Leu Val Asn Ile Gly Gly
            100                 105                 110         
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Leu Trp
        115                 120                 125             
Ser Ile Ile Leu His Trp Gln Val Lys Asp Val Met Lys Asp Val Met
    130                 135                 140                 
Ser Asp Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val
145                 150                 155                 160 
Arg Gln Thr Thr Arg Pro Tyr Ser Gln Val Asn Val Leu Asn Phe Thr
                165                 170                 175     
Thr Ser Trp Thr Asp Gly Leu Ala Phe Asn Ala Val Leu His Arg His
            180                 185                 190         
Lys Pro Asp Leu Phe Ser Trp Asp Lys Val Val Lys Met Ser Pro Ile
        195                 200                 205             
Glu Arg Leu Glu His Ala Phe Ser Lys Ala Gln Thr Tyr Leu Gly Ile
    210                 215                 220                 
Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Val Arg Leu Pro Asp Lys
225                 230                 235                 240 
Lys Ser Ile Ile Met Tyr Leu Thr Ser Leu Phe Glu Val Leu Pro Gln
                245                 250                 255     
Gln Val Thr Ile Asp Ala Ile Arg Glu Val Glu Thr Leu Pro Arg Lys
            260                 265                 270         
Tyr Lys Lys Glu Cys Glu Glu Glu Ala Ile Asn Ile Gln Ser Thr Ala
        275                 280                 285             
Pro Glu Glu Glu His Glu Ser Pro Arg Ala Glu Thr Pro Ser Thr Val
    290                 295                 300                 
Thr Glu Val Asp Met Asp Leu Asp Ser Tyr Gln Ile Ala Leu Glu Glu
305                 310                 315                 320 
Val Leu Thr Trp Leu Leu Ser Ala Glu Asp Thr Phe Gln Glu Gln Asp
                325                 330                 335     
Asp Ile Ser Asp Asp Val Glu Glu Val Lys Asp Gln Phe Ala Thr His
            340                 345                 350         
Glu Ala Phe Met Met Glu Leu Thr Ala His Gln Ser Ser Val Gly Ser
        355                 360                 365             
Val Leu Gln Ala Gly Asn Gln Leu Ile Thr Gln Gly Thr Leu Ser Asp
    370                 375                 380                 
Glu Glu Glu Phe Glu Ile Gln Glu Gln Met Thr Leu Leu Asn Ala Arg
385                 390                 395                 400 
Trp Glu Ala Leu Arg Val Glu Ser Met Asp Arg Gln Ser Arg Leu His
                405                 410                 415     
Asp Val Leu Met Glu Leu Gln Lys Lys Gln Leu Gln Gln Leu Ser Ala
            420                 425                 430         
Trp Leu Thr Leu Thr Glu Glu Arg Ile Gln Lys Met Glu Thr Cys Pro
        435                 440                 445             
Leu Asp Asp Asp Val Lys Ser Leu Gln Lys Leu Leu Glu Glu His Lys
    450                 455                 460                 
Ser Leu Gln Ser Asp Leu Glu Ala Glu Gln Val Lys Val Asn Ser Leu
465                 470                 475                 480 
Thr His Met Val Val Ile Val Asp Glu Asn Ser Gly Glu Ser Ala Thr
                485                 490                 495     
Ala Ile Leu Glu Asp Gln Leu Gln Lys Leu Gly Glu Arg Trp Thr Ala
            500                 505                 510         
Val Cys Arg Trp Thr Glu Glu Arg Trp Asn Arg Leu Gln Glu Ile Asn
        515                 520                 525             
Ile Leu Trp Gln Glu Leu Leu Glu Glu Gln Cys Leu Leu Lys Ala Trp
    530                 535                 540                 
Leu Thr Glu Lys Glu Glu Ala Leu Asn Lys Val Gln Thr Ser Asn Phe
545                 550                 555                 560 
Lys Asp Gln Lys Glu Leu Ser Val Ser Val Arg Arg Leu Ala Ile Leu
                565                 570                 575     
Lys Glu Asp Met Glu Met Lys Arg Gln Thr Leu Asp Gln Leu Ser Glu
            580                 585                 590         
Ile Gly Gln Asp Val Gly Gln Leu Leu Asp Asn Ser Lys Ala Ser Lys
        595                 600                 605             
Lys Ile Asn Ser Asp Ser Glu Glu Leu Thr Gln Arg Trp Asp Ser Leu
    610                 615                 620                 
Val Gln Arg Leu Glu Asp Ser Ser Asn Gln Val Thr Gln Ala Val Ala
625                 630                 635                 640 
Lys Leu Gly Met Ser Gln Ile Pro Gln Lys Asp Leu Leu Glu Thr Val
                645                 650                 655     
Arg Val Arg Glu Gln Ala Ile Thr Lys Lys Ser Lys Gln Glu Leu Pro
            660                 665                 670         
Pro Pro Pro Pro Pro Lys Lys Arg Gln Ile His Val Asp Ile Glu Ala
        675                 680                 685             
Lys Lys Lys Phe Asp Ala Ile Ser Ala Glu Leu Leu Asn Trp Ile Leu
    690                 695                 700                 
Lys Trp Lys Thr Ala Ile Gln Thr Thr Glu Ile Lys Glu Tyr Met Lys
705                 710                 715                 720 
Met Gln Asp Thr Ser Glu Met Lys Lys Lys Leu Lys Ala Leu Glu Lys
                725                 730                 735     
Glu Gln Arg Glu Arg Ile Pro Arg Ala Asp Glu Leu Asn Gln Thr Gly
            740                 745                 750         
Gln Ile Leu Val Glu Gln Met Gly Lys Glu Gly Leu Pro Thr Glu Glu
        755                 760                 765             
Ile Lys Asn Val Leu Glu Lys Val Ser Ser Glu Trp Lys Asn Val Ser
    770                 775                 780                 
Gln His Leu Glu Asp Leu Glu Arg Lys Ile Gln Leu Gln Glu Asp Ile
785                 790                 795                 800 
Asn Ala Tyr Phe Lys Gln Leu Asp Glu Leu Glu Lys Val Ile Lys Thr
                805                 810                 815     
Lys Glu Glu Trp Val Lys His Thr Ser Ile Ser Glu Ser Ser Arg Gln
            820                 825                 830         
Ser Leu Pro Ser Leu Lys Asp Ser Cys Gln Arg Glu Leu Thr Asn Leu
        835                 840                 845             
Leu Gly Leu His Pro Lys Ile Glu Met Ala Arg Ala Ser Cys Ser Ala
    850                 855                 860                 
Leu Met Ser Gln Pro Ser Ala Pro Asp Phe Val Gln Arg Gly Phe Asp
865                 870                 875                 880 
Ser Phe Leu Gly Arg Tyr Gln Ala Val Gln Glu Ala Val Glu Asp Arg
                885                 890                 895     
Gln Gln His Leu Glu Asn Glu Leu Lys Gly Gln Pro Gly His Ala Tyr
            900                 905                 910         
Leu Glu Thr Leu Lys Thr Leu Lys Asp Val Leu Asn Asp Ser Glu Asn
        915                 920                 925             
Lys Ala Gln Val Ser Leu Asn Val Leu Asn Asp Leu Ala Lys Val Glu
    930                 935                 940                 
Lys Ala Leu Gln Glu Lys Lys Thr Leu Asp Glu Ile Leu Glu Asn Gln
945                 950                 955                 960 
Lys Pro Ala Leu His Lys Leu Ala Glu Glu Thr Lys Ala Leu Glu Lys
                965                 970                 975     
Asn Val His Pro Asp Val Glu Lys Leu Tyr Lys Gln Glu Phe Asp Asp
            980                 985                 990         
Val Gln Gly Lys Trp Asn Lys Leu Lys Val Leu Val Ser Lys Asp Leu
        995                 1000                1005            
His Leu Leu Glu Glu Ile Ala Leu Thr Leu Arg Ala Phe Glu Ala Asp
    1010                1015                1020                
Ser Thr Val Ile Glu Lys Trp Met Asp Gly Val Lys Asp Phe Leu Met
1025                1030                1035                1040
Lys Gln Gln Ala Ala Gln Gly Asp Asp Ala Gly Leu Gln Arg Gln Leu
                1045                1050                1055    
Asp Gln Cys Ser Ala Phe Val Asn Glu Ile Glu Thr Ile Glu Ser Ser
            1060                1065                1070        
Leu Lys Asn Met Lys Glu Ile Glu Thr Asn Leu Arg Ser Gly Pro Val
        1075                1080                1085            
Ala Gly Ile Lys Thr Trp Val Gln Thr Arg Leu Gly Asp Tyr Gln Thr
    1090                1095                1100                
Gln Leu Glu Lys Leu Ser Lys Glu Ile Ala Thr Gln Lys Ser Arg Leu
1105                1110                1115                1120
Ser Glu Ser Gln Glu Lys Ala Ala Asn Leu Lys Lys Asp Leu Ala Glu
                1125                1130                1135    
Met Gln Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp
            1140                1145                1150        
Phe Glu Tyr Lys Ser Pro Glu Glu Leu Glu Ser Ala Val Glu Glu Met
        1155                1160                1165            
Lys Arg Ala Lys Glu Asp Val Leu Gln Lys Glu Val Arg Val Lys Ile
    1170                1175                1180                
Leu Lys Asp Asn Ile Lys Leu Leu Ala Ala Lys Val Pro Ser Gly Gly
1185                1190                1195                1200
Gln Glu Leu Thr Ser Glu Leu Asn Val Val Leu Glu Asn Tyr Gln Leu
                1205                1210                1215    
Leu Cys Asn Arg Ile Arg Gly Lys Cys His Thr Leu Glu Glu Val Trp
            1220                1225                1230        
Ser Cys Trp Ile Glu Leu Leu His Tyr Leu Asp Leu Glu Thr Thr Trp
        1235                1240                1245            
Leu Asn Thr Leu Glu Glu Arg Met Lys Ser Thr Glu Val Leu Pro Glu
    1250                1255                1260                
Lys Thr Asp Ala Val Asn Glu Ala Leu Glu Ser Leu Glu Ser Val Leu
1265                1270                1275                1280
Arg His Pro Ala Asp Asn Arg Thr Gln Ile Arg Glu Leu Gly Gln Thr
                1285                1290                1295    
Leu Ile Asp Gly Gly Ile Leu Asp Asp Ile Ile Ser Glu Lys Leu Glu
            1300                1305                1310        
Ala Phe Asn Ser Arg Tyr Glu Asp Leu Ser His Leu Ala Glu Ser Lys
        1315                1320                1325            
Gln Ile Ser Leu Glu Lys Gln Leu Gln Val Leu Arg Glu Thr Asp Gln
    1330                1335                1340                
Met Leu Gln Val Leu Gln Glu Ser Leu Gly Glu Leu Asp Lys Gln Leu
1345                1350                1355                1360
Thr Thr Tyr Leu Thr Asp Arg Ile Asp Ala Phe Gln Val Pro Gln Glu
                1365                1370                1375    
Ala Gln Lys Ile Gln Ala Glu Ile Ser Ala His Glu Leu Thr Leu Glu
            1380                1385                1390        
Glu Leu Arg Arg Asn Met Arg Ser Gln Pro Leu Thr Ser Pro Glu Ser
        1395                1400                1405            
Arg Thr Ala Arg Gly Gly Ser Gln Met Asp Val Leu Gln Arg Lys Leu
    1410                1415                1420                
Arg Glu Val Ser Thr Lys Phe Gln Leu Phe Gln Lys Pro Ala Asn Phe
1425                1430                1435                1440
Glu Gln Arg Met Leu Asp Cys Lys Arg Val Leu Asp Gly Val Lys Ala
                1445                1450                1455    
Glu Leu His Val Leu Asp Val Lys Asp Val Asp Pro Asp Val Ile Gln
            1460                1465                1470        
Thr His Leu Asp Lys Cys Met Lys Leu Tyr Lys Thr Leu Ser Glu Val
        1475                1480                1485            
Lys Leu Glu Val Glu Thr Val Ile Lys Thr Gly Arg His Ile Val Gln
    1490                1495                1500                
Lys Gln Gln Thr Asp Asn Pro Lys Gly Met Asp Glu Gln Leu Thr Ser
1505                1510                1515                1520
Leu Lys Val Leu Tyr Asn Asp Leu Gly Ala Gln Val Thr Glu Gly Lys
                1525                1530                1535    
Gln Asp Leu Glu Arg Ala Ser Gln Leu Ala Arg Lys Met Lys Lys Glu
            1540                1545                1550        
Ala Ala Ser Leu Ser Glu Trp Leu Ser Ala Thr Glu Thr Glu Leu Val
        1555                1560                1565            
Gln Lys Ser Thr Ser Glu Gly Leu Leu Gly Asp Leu Asp Thr Glu Ile
    1570                1575                1580                
Ser Trp Ala Lys Asn Val Leu Lys Asp Leu Glu Lys Arg Lys Ala Asp
1585                1590                1595                1600
Leu Asn Thr Ile Thr Glu Ser Ser Ala Ala Leu Gln Asn Leu Ile Glu
                1605                1610                1615    
Gly Ser Glu Pro Ile Leu Glu Glu Arg Leu Cys Val Leu Asn Ala Gly
            1620                1625                1630        
Trp Ser Arg Val Arg Thr Trp Thr Glu Asp Trp Cys Asn Thr Leu Met
        1635                1640                1645            
Asn His Gln Asn Gln Leu Glu Ile Phe Asp Gly Asn Val Ala His Ile
    1650                1655                1660                
Ser Thr Trp Leu Tyr Gln Ala Glu Ala Leu Leu Asp Glu Ile Glu Lys
1665                1670                1675                1680
Lys Pro Thr Ser Lys Gln Glu Glu Ile Val Lys Arg Leu Val Ser Glu
                1685                1690                1695    
Leu Asp Asp Ala Asn Leu Gln Val Glu Asn Val Arg Asp Gln Ala Leu
            1700                1705                1710        
Ile Leu Met Asn Ala Arg Gly Ser Ser Ser Arg Glu Leu Val Glu Pro
        1715                1720                1725            
Lys Leu Ala Glu Leu Asn Arg Asn Phe Glu Lys Val Ser Gln His Ile
    1730                1735                1740                
Lys Ser Ala Lys Leu Leu Ile Ala Gln Glu Pro Leu Tyr Gln Cys Leu
1745                1750                1755                1760
Val Thr Thr Glu Thr Phe Glu Thr Gly Val Pro Phe Ser Asp Leu Glu
                1765                1770                1775    
Lys Leu Glu Asn Asp Ile Glu Asn Met Leu Lys Phe Val Glu Lys His
            1780                1785                1790        
Leu Glu Ser Ser Asp Glu Asp Glu Lys Met Asp Glu Glu Ser Ala Gln
        1795                1800                1805            
Ile Glu Glu Val Leu Gln Arg Gly Glu Glu Met Leu His Gln Pro Met
    1810                1815                1820                
Glu Asp Asn Lys Lys Glu Lys Ile Arg Leu Gln Leu Leu Leu Leu His
1825                1830                1835                1840
Thr Arg Tyr Asn Lys Ile Lys Ala Ile Pro Ile Gln Gln Arg Lys Met
                1845                1850                1855    
Gly Gln Leu Ala Ser Gly Ile Arg Ser Ser Leu Leu Pro Thr Asp Tyr
            1860                1865                1870        
Leu Val Glu Ile Asn Lys Ile Leu Leu Cys Met Asp Asp Val Glu Leu
        1875                1880                1885            
Ser Leu Asn Val Pro Glu Leu Asn Thr Ala Ile Tyr Glu Asp Phe Ser
    1890                1895                1900                
Phe Gln Glu Asp Ser Leu Lys Asn Ile Lys Asp Gln Leu Asp Lys Leu
1905                1910                1915                1920
Gly Glu Gln Ile Ala Val Ile His Glu Lys Gln Pro Asp Val Ile Leu
                1925                1930                1935    
Glu Ala Ser Gly Pro Glu Ala Ile Gln Ile Arg Asp Thr Leu Thr Gln
            1940                1945                1950        
Leu Asn Ala Lys Trp Asp Arg Ile Asn Arg Met Tyr Ser Asp Arg Lys
        1955                1960                1965            
Gly Cys Phe Asp Arg Ala Met Glu Glu Trp Arg Gln Phe His Cys Asp
    1970                1975                1980                
Leu Asn Asp Leu Thr Gln Trp Ile Thr Glu Ala Glu Glu Leu Leu Val
1985                1990                1995                2000
Asp Thr Cys Ala Pro Gly Gly Ser Leu Asp Leu Glu Lys Ala Arg Ile
                2005                2010                2015    
His Gln Gln Glu Leu Glu Val Gly Ile Ser Ser His Gln Pro Ser Phe
            2020                2025                2030        
Ala Ala Leu Asn Arg Thr Gly Asp Gly Ile Val Gln Lys Leu Ser Gln
        2035                2040                2045            
Ala Asp Gly Ser Phe Leu Lys Glu Lys Leu Ala Gly Leu Asn Gln Arg
    2050                2055                2060                
Trp Asp Ala Ile Val Ala Glu Val Lys Asp Arg Gln Pro Arg Leu Lys
2065                2070                2075                2080
Gly Glu Ser Lys Gln Val Met Lys Tyr Arg His Gln Leu Asp Glu Ile
                2085                2090                2095    
Ile Cys Trp Leu Thr Lys Ala Glu His Ala Met Gln Lys Arg Ser Thr
            2100                2105                2110        
Thr Glu Leu Gly Glu Asn Leu Gln Glu Leu Arg Asp Leu Thr Gln Glu
        2115                2120                2125            
Met Glu Val His Ala Glu Lys Leu Lys Trp Leu Asn Arg Thr Glu Leu
    2130                2135                2140                
Glu Met Leu Ser Asp Lys Ser Leu Ser Leu Pro Glu Arg Asp Lys Ile
2145                2150                2155                2160
Ser Glu Ser Leu Arg Thr Val Asn Met Thr Trp Asn Lys Ile Cys Arg
                2165                2170                2175    
Glu Val Pro Thr Thr Leu Lys Glu Cys Ile Gln Glu Pro Ser Ser Val
            2180                2185                2190        
Ser Gln Thr Arg Ile Ala Ala His Pro Asn Val Gln Lys Val Val Leu
        2195                2200                2205            
Val Ser Ser Ala Ser Asp Ile Pro Val Gln Ser His Arg Thr Ser Glu
    2210                2215                2220                
Ile Ser Ile Pro Ala Asp Leu Asp Lys Thr Ile Thr Glu Leu Ala Asp
2225                2230                2235                2240
Trp Leu Val Leu Ile Asp Gln Met Leu Lys Ser Asn Ile Val Thr Val
                2245                2250                2255    
Gly Asp Val Glu Glu Ile Asn Lys Thr Val Ser Arg Met Lys Ile Thr
            2260                2265                2270        
Lys Ala Asp Leu Glu Gln Arg His Pro Gln Leu Asp Tyr Val Phe Thr
        2275                2280                2285            
Leu Ala Gln Asn Leu Lys Asn Lys Ala Ser Ser Ser Asp Met Arg Thr
    2290                2295                2300                
Ala Ile Thr Glu Lys Leu Glu Arg Val Lys Asn Gln Trp Asp Gly Thr
2305                2310                2315                2320
Gln His Gly Val Glu Leu Arg Gln Gln Gln Leu Glu Asp Met Ile Ile
                2325                2330                2335    
Asp Ser Leu Gln Trp Asp Asp His Arg Glu Glu Thr Glu Glu Leu Met
            2340                2345                2350        
Arg Lys Tyr Glu Ala Arg Leu Tyr Ile Leu Gln Gln Ala Arg Arg Asp
        2355                2360                2365            
Pro Leu Thr Lys Gln Ile Ser Asp Asn Gln Ile Leu Leu Gln Glu Leu
    2370                2375                2380                
Gly Pro Gly Asp Gly Ile Val Met Ala Phe Asp Asn Val Leu Gln Lys
2385                2390                2395                2400
Leu Leu Glu Glu Tyr Gly Ser Asp Asp Thr Arg Asn Val Lys Glu Thr
                2405                2410                2415    
Thr Glu Tyr Leu Lys Thr Ser Trp Ile Asn Leu Lys Gln Ser Ile Ala
            2420                2425                2430        
Asp Arg Gln Asn Ala Leu Glu Ala Glu Trp Arg Thr Val Gln Ala Ser
        2435                2440                2445            
Arg Arg Asp Leu Glu Asn Phe Leu Lys Trp Ile Gln Glu Ala Glu Thr
    2450                2455                2460                
Thr Val Asn Val Leu Val Asp Ala Ser His Arg Glu Asn Ala Leu Gln
2465                2470                2475                2480
Asp Ser Ile Leu Ala Arg Glu Leu Lys Gln Gln Met Gln Asp Ile Gln
                2485                2490                2495    
Ala Glu Ile Asp Ala His Asn Asp Ile Phe Lys Ser Ile Asp Gly Asn
            2500                2505                2510        
Arg Gln Lys Met Val Lys Ala Leu Gly Asn Ser Glu Glu Ala Thr Met
        2515                2520                2525            
Leu Gln His Arg Leu Asp Asp Met Asn Gln Arg Trp Asn Asp Leu Lys
    2530                2535                2540                
Ala Lys Ser Ala Ser Ile Arg Ala His Leu Glu Ala Ser Ala Glu Lys
2545                2550                2555                2560
Trp Asn Arg Leu Leu Met Ser Leu Glu Glu Leu Ile Lys Trp Leu Asn
                2565                2570                2575    
Met Lys Asp Glu Glu Leu Lys Lys Gln Met Pro Ile Gly Gly Asp Val
            2580                2585                2590        
Pro Ala Leu Gln Leu Gln Tyr Asp His Cys Lys Ala Leu Arg Arg Glu
        2595                2600                2605            
Leu Lys Glu Lys Glu Tyr Ser Val Leu Asn Ala Val Asp Gln Ala Arg
    2610                2615                2620                
Val Phe Leu Ala Asp Gln Pro Ile Glu Ala Pro Glu Glu Pro Arg Arg
2625                2630                2635                2640
Asn Leu Gln Ser Lys Thr Glu Leu Thr Pro Glu Glu Arg Ala Gln Lys
                2645                2650                2655    
Ile Ala Lys Ala Met Arg Lys Gln Ser Ser Glu Val Lys Glu Lys Trp
            2660                2665                2670        
Glu Ser Leu Asn Ala Val Thr Ser Asn Trp Gln Lys Gln Val Asp Lys
        2675                2680                2685            
Ala Leu Glu Lys Leu Arg Asp Leu Gln Gly Ala Met Asp Asp Leu Asp
    2690                2695                2700                
Ala Asp Met Lys Glu Ala Glu Ser Val Arg Asn Gly Trp Lys Pro Val
2705                2710                2715                2720
Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Ile Glu Lys Ile Met
                2725                2730                2735    
Ala Phe Arg Glu Glu Ile Ala Pro Ile Asn Phe Lys Val Lys Thr Val
            2740                2745                2750        
Asn Asp Leu Ser Ser Gln Leu Ser Pro Leu Asp Leu His Pro Ser Leu
        2755                2760                2765            
Lys Met Ser Arg Gln Leu Asp Asp Leu Asn Met Arg Trp Lys Leu Leu
    2770                2775                2780                
Gln Val Ser Val Asp Asp Arg Leu Lys Gln Leu Gln Glu Ala His Arg
2785                2790                2795                2800
Asp Phe Gly Pro Ser Ser Gln His Phe Leu Ser Thr Ser Val Gln Leu
                2805                2810                2815    
Pro Trp Gln Arg Ser Ile Ser His Asn Lys Val Pro Tyr Tyr Ile Asn
            2820                2825                2830        
His Gln Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu
        2835                2840                2845            
Phe Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg
    2850                2855                2860                
Thr Ala Ile Lys Ile Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu
2865                2870                2875                2880
Leu Glu Leu Ser Thr Thr Asn Glu Ile Phe Lys Gln His Lys Leu Asn
                2885                2890                2895    
Gln Asn Asp Gln Leu Leu Ser Val Pro Asp Val Ile Asn Cys Leu Thr
            2900                2905                2910        
Thr Thr Tyr Asp Gly Leu Glu Gln Met His Lys Asp Leu Val Asn Val
        2915                2920                2925            
Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp
    2930                2935                2940                
Thr Gly Arg Thr Gly Lys Ile Arg Val Gln Ser Leu Lys Ile Gly Leu
2945                2950                2955                2960
Met Ser Leu Ser Lys Gly Leu Leu Glu Glu Lys Tyr Arg Tyr Leu Phe
                2965                2970                2975    
Lys Glu Val Ala Gly Pro Thr Glu Met Cys Asp Gln Arg Gln Leu Gly
            2980                2985                2990        
Leu Leu Leu His Asp Ala Ile Gln Ile Pro Arg Gln Leu Gly Glu Val
        2995                3000                3005            
Ala Ala Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe
    3010                3015                3020                
Gln Gln Asn Asn Asn Lys Pro Glu Ile Ser Val Lys Glu Phe Ile Asp
3025                3030                3035                3040
Trp Met His Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His
                3045                3050                3055    
Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile
            3060                3065                3070        
Cys Lys Glu Cys Pro Ile Val Gly Phe Arg Tyr Arg Ser Leu Lys His
        3075                3080                3085            
Phe Asn Tyr Asp Val Cys Gln Ser Cys Phe Phe Ser Gly Arg Thr Ala
    3090                3095                3100                
Lys Gly His Lys Leu His Tyr Pro Met Val Glu Tyr Cys Ile Pro Thr
3105                3110                3115                3120
Thr Ser Gly Glu Asp Val Arg Asp Phe Thr Lys Val Leu Lys Asn Lys
                3125                3130                3135    
Phe Arg Ser Lys Lys Tyr Phe Ala Lys His Pro Arg Leu Gly Tyr Leu
            3140                3145                3150        
Pro Val Gln Thr Val Leu Glu Gly Asp Asn Leu Glu Thr Pro Ile Thr
        3155                3160                3165            
Leu Ile Ser Met Trp Pro Glu His Tyr Asp Pro Ser Gln Ser Pro Gln
    3170                3175                3180                
Leu Phe His Asp Asp Thr His Ser Arg Ile Glu Gln Tyr Ala Thr Arg
3185                3190                3195                3200
Leu Ala Gln Met Glu Arg Thr Asn Gly Ser Phe Leu Thr Asp Ser Ser
                3205                3210                3215    
Ser Thr Thr Gly Ser Val Glu Asp Glu His Ala Leu Ile Gln Gln Tyr
            3220                3225                3230        
Cys Gln Thr Leu Gly Gly Glu Ser Pro Val Ser Gln Pro Gln Ser Pro
        3235                3240                3245            
Ala Gln Ile Leu Lys Ser Val Glu Arg Glu Glu Arg Gly Glu Leu Glu
    3250                3255                3260                
Arg Ile Ile Ala Asp Leu Glu Glu Glu Gln Arg Asn Leu Gln Val Glu
3265                3270                3275                3280
Tyr Glu Gln Leu Lys Asp Gln His Leu Arg Arg Gly Leu Pro Val Gly
                3285                3290                3295    
Ser Pro Pro Glu Ser Ile Ile Ser Pro His His Thr Ser Glu Asp Ser
            3300                3305                3310        
Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu
        3315                3320                3325            
Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser
    3330                3335                3340                
Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Glu Ser Asp Ser
3345                3350                3355                3360
Arg Ile Asn Gly Val Ser Pro Trp Ala Ser Pro Gln His Ser Ala Leu
                3365                3370                3375    
Ser Tyr Ser Leu Asp Pro Asp Ala Ser Gly Pro Gln Phe His Gln Ala
            3380                3385                3390        
Ala Gly Glu Asp Leu Leu Ala Pro Pro His Asp Thr Ser Thr Asp Leu
        3395                3400                3405            
Thr Glu Val Met Glu Gln Ile His Ser Thr Phe Pro Ser Cys Cys Pro
    3410                3415                3420                
Asn Val Pro Ser Arg Pro Gln Ala Met
3425                3430            


<210> 7478
<211> 316
<212> PRT
<213> Homo sapiens

<400> 7478
Met Leu Leu Leu Glu Leu Asn Ala Pro Glu His Val Leu Glu Thr Ile
 1               5                  10                  15      
Asn Phe Gln Thr Leu Thr Ala Phe Cys Asn Thr Phe His Ile Leu Arg
            20                  25                  30          
Pro Thr Lys Ala Pro Gly Phe Val Tyr Ala Trp Leu Glu Leu Ile Ser
        35                  40                  45              
His Arg Ile Phe Ile Ala Arg Met Leu Ala His Thr Pro Gln Gln Lys
    50                  55                  60                  
Gly Trp Pro Met Tyr Ala Gln Leu Leu Ile Asp Leu Phe Lys Tyr Leu
65                  70                  75                  80  
Ala Pro Phe Leu Arg Asn Val Glu Leu Thr Lys Pro Met Gln Ile Leu
                85                  90                  95      
Tyr Lys Gly Thr Leu Arg Val Leu Leu Val Leu Leu His Asp Phe Pro
            100                 105                 110         
Glu Phe Leu Cys Asp Tyr His Tyr Gly Phe Cys Asp Val Ile Pro Pro
        115                 120                 125             
Asn Cys Ile Gln Leu Arg Asn Leu Ile Leu Ser Ala Phe Pro Arg Asn
    130                 135                 140                 
Met Arg Leu Pro Asp Pro Phe Thr Pro Asn Leu Lys Val Asp Met Leu
145                 150                 155                 160 
Ser Glu Ile Asn Ile Ala Pro Arg Ile Leu Thr Asn Phe Thr Gly Val
                165                 170                 175     
Met Pro Pro Gln Phe Lys Lys Asp Leu Asp Ser Tyr Leu Lys Thr Arg
            180                 185                 190         
Ser Pro Val Thr Phe Leu Ser Asp Leu Arg Arg Thr Val Gln Val Ser
        195                 200                 205             
Asn Glu Pro Gly Asn Arg Tyr Asn Leu Gln Leu Ile Asn Ala Leu Val
    210                 215                 220                 
Leu Tyr Val Gly Thr Gln Ala Ile Ala His Ile His Asn Lys Gly Ser
225                 230                 235                 240 
Thr Pro Ser Met Ser Thr Ile Thr His Ser Ala His Met Asp Ile Phe
                245                 250                 255     
Gln Asn Leu Ala Val Asp Leu Asp Thr Glu Gly Arg Tyr Leu Phe Leu
            260                 265                 270         
Asn Ala Ile Ala Asn His Ser Gly Thr Gln Ile Ala Thr Leu Thr Thr
        275                 280                 285             
Ser Val Ala Pro Cys Cys Thr Phe Leu Gln Arg Pro Ile Arg Lys Pro
    290                 295                 300                 
Ser Lys Asn Arg Ser Gln Glu Phe Ser Trp Asn Gly
305                 310                 315     


<210> 7479
<211> 61
<212> PRT
<213> Homo sapiens

<400> 7479
Met Lys Leu His Arg Ile Ile Arg Lys Arg Leu Ser Gly Cys Pro Arg
 1               5                  10                  15      
Thr Cys Phe His Lys Glu Lys Thr Pro Arg Ile Leu Lys Val Ala Glu
            20                  25                  30          
Phe Phe Asn Tyr Ser Lys Asn Arg Ile Gln Ile Leu Pro Cys Lys Phe
        35                  40                  45              
Leu Leu Ser Tyr Arg Ile Ile Leu Leu Glu Leu Glu Tyr
    50                  55                  60      


<210> 7480
<211> 224
<212> PRT
<213> Homo sapiens

<400> 7480
Met Ala Ser Lys Lys Glu Pro Lys Lys Glu Leu Gly Leu His Arg Gly
 1               5                  10                  15      
Ile Leu His Phe Tyr Pro Gly Ser Asp Gln Pro Asp Gly Arg His Cys
            20                  25                  30          
His Arg His Glu Tyr Ile Leu Ala Pro Gly Ala Pro Ala Thr Ser Ser
        35                  40                  45              
Ser Val Ala Gln Glu Thr Pro Ser Ser Leu Phe Arg Ile His Thr Val
    50                  55                  60                  
Tyr Met Ile Asp Thr Gly Asn Val Glu Glu His Val Ser His Lys Thr
65                  70                  75                  80  
Val Thr Asn Pro Asp Lys Leu Pro Lys Thr Ala Glu Asn Phe His Ala
                85                  90                  95      
Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys Phe His
            100                 105                 110         
Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly Gly Phe Thr Cys His
        115                 120                 125             
Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu Lys Leu Asp Asp Glu
    130                 135                 140                 
Asn Phe Ile Leu Lys His Thr Cys Pro Gly Thr Leu Ser Met Ala Asn
145                 150                 155                 160 
Ala Gly Pro Asn Thr Asn Gly Ser Arg Phe Phe Ile Cys Thr Ala Lys
                165                 170                 175     
Thr Val Val Gly Gln Lys His Val Val Ser Ser Lys Val Lys Glu Gly
            180                 185                 190         
Met Asn Ile Val Gly Ala Met Glu His Phe Gly Ser Arg Asn Gly Lys
        195                 200                 205             
Thr Ser Lys Met Ile Thr Thr Ala Asp Cys Gly Gln Leu Glu Tyr Ile
    210                 215                 220                 


<210> 7481
<211> 147
<212> PRT
<213> Homo sapiens

<400> 7481
Met Ala Glu Arg Pro Glu Asp Leu Asn Leu Pro Asn Ala Val Ile Thr
 1               5                  10                  15      
Arg Ile Ile Lys Glu Ala Leu Pro Asp Gly Val Asn Ile Ser Lys Glu
            20                  25                  30          
Ala Arg Ser Ala Ile Ser Arg Ala Ala Ser Val Phe Val Leu Tyr Ala
        35                  40                  45              
Thr Ser Cys Ala Asn Asn Phe Ala Met Lys Gly Lys Arg Lys Thr Leu
    50                  55                  60                  
Asn Ala Ser Asp Val Leu Ser Ala Met Glu Glu Met Glu Phe Gln Arg
65                  70                  75                  80  
Phe Val Thr Pro Leu Lys Glu Ala Leu Glu Ala Tyr Arg Arg Glu Gln
                85                  90                  95      
Lys Gly Lys Lys Glu Ala Ser Glu Gln Lys Lys Lys Asp Lys Asp Lys
            100                 105                 110         
Lys Thr Asp Ser Glu Glu Gln Asp Lys Ser Arg Asp Glu Asp Asn Asp
        115                 120                 125             
Glu Asp Glu Glu Arg Leu Glu Glu Glu Glu Gln Asn Glu Glu Glu Glu
    130                 135                 140                 
Val Asp Asn
145         


<210> 7482
<211> 525
<212> PRT
<213> Homo sapiens

<400> 7482
Met Leu Gly Lys Arg Lys Arg Val Val Leu Thr Ile Lys Asp Lys Leu
 1               5                  10                  15      
Asp Ile Ile Lys Lys Leu Glu Glu Gly Ile Ser Phe Lys Lys Leu Ser
            20                  25                  30          
Val Val Tyr Gly Ile Gly Glu Ser Thr Val Arg Asp Ile Lys Lys Asn
        35                  40                  45              
Lys Glu Arg Ile Ile Asn Tyr Ala Asn Ser Ser Asp Pro Thr Ser Gly
    50                  55                  60                  
Val Ser Lys Arg Lys Ser Met Lys Ser Ser Thr Tyr Glu Glu Leu Asp
65                  70                  75                  80  
Arg Val Met Ile Glu Trp Phe Asn Gln Gln Lys Thr Asp Gly Ile Pro
                85                  90                  95      
Val Ser Gly Thr Ile Cys Ala Lys Gln Ala Lys Phe Phe Phe Asp Ala
            100                 105                 110         
Leu Gly Met Glu Gly Asp Phe Asn Ala Ser Ser Gly Trp Leu Thr Arg
        115                 120                 125             
Phe Lys Gln Arg His Gly Ile Pro Lys Ala Ala Gly Lys Gly Thr Lys
    130                 135                 140                 
Leu Lys Gly Asp Glu Thr Ala Ala Arg Glu Phe Cys Gly Ser Phe Gln
145                 150                 155                 160 
Glu Phe Val Glu Lys Glu Asn Leu Gln Pro Glu Gln Ile Tyr Gly Ala
                165                 170                 175     
Asp Gln Thr Gly Leu Phe Trp Lys Cys Leu Pro Ser Arg Thr Leu Thr
            180                 185                 190         
Leu Glu Thr Asp Gln Ser Thr Ser Gly Cys Arg Ser Ser Arg Glu Arg
        195                 200                 205             
Ile Ile Ile Met Cys Cys Ala Asn Ala Thr Gly Leu His Lys Leu Asn
    210                 215                 220                 
Leu Cys Val Val Gly Lys Ala Lys Lys Pro Arg Ala Phe Lys Gly Thr
225                 230                 235                 240 
Asp Leu Ser Asn Leu Pro Val Thr Tyr Tyr Ser Gln Lys Gly Ala Trp
                245                 250                 255     
Ile Glu Gln Ser Val Phe Arg Gln Trp Phe Glu Lys Tyr Phe Val Pro
            260                 265                 270         
Gln Val Gln Lys His Leu Lys Ser Lys Gly Leu Leu Glu Lys Ala Val
        275                 280                 285             
Leu Leu Leu Asp Phe Pro Pro Ala Arg Pro Asn Glu Glu Met Leu Ser
    290                 295                 300                 
Ser Asp Asp Gly Arg Ile Ile Val Lys Tyr Leu Pro Pro Asn Val Thr
305                 310                 315                 320 
Ser Leu Ile Gln Pro Met Ser Gln Gly Val Leu Ala Thr Val Lys Arg
                325                 330                 335     
Tyr Tyr Arg Ala Gly Leu Leu Gln Lys Tyr Met Asp Glu Gly Asn Asp
            340                 345                 350         
Pro Lys Ile Phe Trp Lys Asn Leu Thr Val Leu Asp Ala Ile Tyr Glu
        355                 360                 365             
Val Ser Arg Ala Trp Asn Met Val Lys Ser Ser Thr Ile Thr Lys Ala
    370                 375                 380                 
Trp Lys Lys Leu Phe Pro Gly Asn Glu Glu Asn Ser Gly Met Asn Ile
385                 390                 395                 400 
Asp Glu Gly Ala Ile Leu Ala Ala Asn Leu Ala Thr Val Leu Gln Asn
                405                 410                 415     
Thr Glu Glu Cys Glu His Val Asp Ile Glu Asn Ile Asp Gln Trp Phe
            420                 425                 430         
Asp Ser Arg Ser Ser Asp Ser Ser Cys Gln Val Leu Thr Asp Ser Glu
        435                 440                 445             
Ser Ala Glu Asp Gln Thr Lys Ala Ala Glu Gln Lys Pro Ser Ser Lys
    450                 455                 460                 
Ser Arg Lys Thr Glu Leu Asn Pro Glu Lys His Ile Ser His Lys Ala
465                 470                 475                 480 
Ala Leu Glu Trp Thr Glu Asn Leu Leu Asp Tyr Leu Glu Gln Gln Asp
                485                 490                 495     
Asp Met Leu Leu Ser Asp Lys Leu Val Leu Arg Arg Leu Arg Thr Ile
            500                 505                 510         
Ile Arg Lys Lys Gln Lys Ile Gln Asn Asn Lys Asn His
        515                 520                 525 


<210> 7483
<211> 1890
<212> PRT
<213> Homo sapiens

<400> 7483
Met Leu Ser Leu Gln Asn Ile Leu Asn Gly Leu Gly Ala Ala Ala Ala
 1               5                  10                  15      
Pro Cys His Arg Asp Val Tyr Lys Ala Ala Arg Ser Cys Leu Thr Asp
            20                  25                  30          
Arg Ser Met Ala Val Arg Cys Ala Ala Ala Lys Cys Leu Leu Glu Leu
        35                  40                  45              
Gln Asn Glu Ala Ile Phe Met Trp Ser Thr Asp Leu Asp Ser Val Ala
    50                  55                  60                  
Thr Leu Cys Phe Lys Ser Phe Glu Gly Ser Asn Tyr Asp Val Arg Ile
65                  70                  75                  80  
Ser Val Ser Lys Leu Leu Gly Ile Ile Leu Ala Lys Ala Val Ile Ser
                85                  90                  95      
Lys His Pro Gly Thr Ala Ala Ser Arg Gln Ser Ile Arg Arg Val Ser
            100                 105                 110         
Leu Glu Glu Val Leu Glu Leu Leu Gly Thr Gly Phe Leu Arg Gly Ser
        115                 120                 125             
Ser Gly Phe Leu Arg Ala Ser Gly Asp Met Leu Lys Gly Thr Ser Ser
    130                 135                 140                 
Val Ser Arg Asp Val Arg Val Gly Val Thr Gln Ala Tyr Val Val Phe
145                 150                 155                 160 
Val Ser Thr Leu Gly Gly Ala Trp Leu Glu Lys Asn Phe Ala Ala Phe
                165                 170                 175     
Phe Ser His Ile Leu Ser Leu Ala Ser Pro Ser His Pro Lys Ala Thr
            180                 185                 190         
Gln Thr Gln Ile Asp Ala Val Cys Cys Arg Arg Cys Val Ser Phe Ile
        195                 200                 205             
Leu Arg Thr Thr Ile Gly Gly Leu Leu Gly Glu Lys Ala Gln Leu Ala
    210                 215                 220                 
Ala Val Lys Asp Ile Cys Gln Ala Ile Trp Lys Leu Lys Lys Val Met
225                 230                 235                 240 
Asp Ala Val Met Ser Asp Gly Asn Leu Glu Thr Arg Leu Gly Ser Thr
                245                 250                 255     
Asp Val Ala Ala Ser Gln His Met Leu Val Cys Ala Leu Gln Glu Leu
            260                 265                 270         
Gly Asn Leu Ile His Asn Leu Gly Thr Thr Ala Ala Pro Leu Leu Gln
        275                 280                 285             
Asp Ser Ser Thr Gly Leu Leu Asp Ser Ile Leu Ser Val Ile Leu His
    290                 295                 300                 
Pro Ser Ile Ser Val Arg Leu Ala Ala Ala Trp Cys Leu His Cys Ile
305                 310                 315                 320 
Ala Val Ala Leu Pro Ser Tyr Leu Thr Pro Leu Leu Asp Arg Cys Leu
                325                 330                 335     
Glu Arg Leu Thr Gly His Lys Ser Ser Pro Glu Ala Val Thr Gly Phe
            340                 345                 350         
Ser Phe Ala Val Ala Ala Leu Leu Gly Ala Val Lys His Cys Pro Leu
        355                 360                 365             
Gly Ile Pro His Gly Lys Gly Lys Ile Ile Met Thr Leu Ala Glu Asp
    370                 375                 380                 
Leu Leu Cys Ser Ala Ala Gln Asn Ser Arg Leu Ser Ala Gln Arg Thr
385                 390                 395                 400 
Gln Ala Gly Trp Leu Leu Ile Ser Ala Leu Met Thr Leu Gly Pro Ala
                405                 410                 415     
Val Val Ser His His Leu Ala Arg Val Leu Leu Leu Trp Lys Cys Val
            420                 425                 430         
Phe Pro Ala Ser Pro Lys Asp Leu Glu Thr Glu Lys Ser Arg Gly Asp
        435                 440                 445             
Ser Phe Thr Trp Gln Val Thr Leu Glu Gly Arg Ala Gly Ala Leu Cys
    450                 455                 460                 
Ala Ile Lys Ser Phe Val Ser His Cys Gly Asp Leu Leu Thr Glu Glu
465                 470                 475                 480 
Val Thr Gln Arg Leu Leu Pro Pro Leu Pro Cys Ala Val Asp Leu Leu
                485                 490                 495     
Thr Gln Leu Ser Ser Ile Leu Lys Met Tyr Gly Ser Pro Leu Lys Thr
            500                 505                 510         
Pro Ser Val Val Tyr Arg Gln Arg Leu Tyr Glu Leu Leu Ile Leu Leu
        515                 520                 525             
Pro Pro Glu Thr Tyr Glu Gly Asn Leu Cys Ala Ile Leu Arg Glu Leu
    530                 535                 540                 
Ala Ala Asp Leu Thr Ala Pro Asp Ile Gln Val Ala Ala Ser Thr Phe
545                 550                 555                 560 
Leu Leu Pro Pro Leu Cys His Gln Asp Asp Leu Leu Ile Leu Ser Pro
                565                 570                 575     
Phe Leu Gln Glu Thr Asp His Arg Phe Ile Glu Glu Gln Leu Leu Leu
            580                 585                 590         
Gly Asn Gly Val Ala Cys Gly Ser Leu Glu Tyr Asp Pro Tyr Ser Ile
        595                 600                 605             
Tyr Glu Lys Asp Val Glu Gly Asp Ser Val Pro Lys Pro Leu Pro Pro
    610                 615                 620                 
Ala Leu Ser Val Ile Ser Ser Ala Ser Lys Leu Phe Gly Val Val Cys
625                 630                 635                 640 
Ala His Val Gly Glu Thr Gln Arg Leu Leu Ile Leu Glu Gln Leu Leu
                645                 650                 655     
Asp Ser Ile Lys His Thr Lys Gly Ala Arg Gln Gln Val Val Gln Leu
            660                 665                 670         
His Val Val Ser Ser Val Ser Ser Phe Leu Lys Tyr Val Ala Gly Ser
        675                 680                 685             
Lys Gly Cys Leu Gly Pro Glu Glu Met Lys Arg Phe Ala Leu Thr Leu
    690                 695                 700                 
Val Met Gly Ala Leu Glu Ser Pro Asn Pro Leu Leu Arg Cys Ala Ala
705                 710                 715                 720 
Ala Glu Ser Trp Ala Arg Leu Ala Gln Val Val Asp Asp Gly Ala Phe
                725                 730                 735     
Thr Ala Gly Leu Ala Gln Val Ser Phe Asp Lys Leu Lys Ser Ala Arg
            740                 745                 750         
Asp Val Val Thr Arg Thr Gly His Ser Leu Ala Leu Gly Ser Leu His
        755                 760                 765             
Arg Tyr Leu Gly Gly Ile Ser Ser Ser Gln His Leu Asn Ser Cys Ile
    770                 775                 780                 
Gly Ile Leu Tyr Thr Leu Ala Gln Asp Ser Thr Ser Pro Asp Val Gln
785                 790                 795                 800 
Thr Trp Ala Leu His Ser Leu Ser Leu Ile Ile Asp Ser Ala Gly Pro
                805                 810                 815     
Leu Tyr Tyr Val His Val Glu Pro Thr Leu Ser Leu Ile Ile Met Leu
            820                 825                 830         
Leu Leu Asn Val Pro Pro Thr His Ala Glu Val His Gln Ser Leu Gly
        835                 840                 845             
Arg Cys Leu Asn Ala Leu Ile Thr Thr Leu Gly Pro Glu Leu Gln Gly
    850                 855                 860                 
Asn Ser Thr Ser Ile Ser Thr Leu Arg Thr Ser Cys Leu Leu Gly Cys
865                 870                 875                 880 
Ala Val Met Gln Asp Asn Pro Asp Cys Leu Val Gln Ala Gln Ala Ile
                885                 890                 895     
Ser Cys Leu Gln Gln Leu His Met Phe Ala Pro Arg His Val Asn Leu
            900                 905                 910         
Ser Ser Leu Val Ser Cys Leu Cys Val Asn Leu Cys Ser Pro Tyr Leu
        915                 920                 925             
Leu Leu Arg Arg Ala Val Leu Ala Cys Leu Arg Gln Leu Val Gln Arg
    930                 935                 940                 
Glu Ala Ala Glu Val Ser Glu His Ala Val Met Leu Ala Lys Asp Ser
945                 950                 955                 960 
Arg Glu Glu Leu Thr Pro Asp Ala Asn Ile Arg Glu Val Gly Leu Glu
                965                 970                 975     
Gly Ala Leu Leu Ile Leu Leu Asp Lys Glu Thr Asp Glu Arg Leu Cys
            980                 985                 990         
His Asp Ile Lys Glu Thr Leu Asn Tyr Met Leu Thr Ser Met Ala Val
        995                 1000                1005            
Glu Lys Leu Ser Leu Trp Leu Lys Leu Cys Lys Asp Val Leu Ala Ala
    1010                1015                1020                
Ser Ala Asp Phe Thr Ala Val Thr Cys Val Asp Thr Met Gln Glu Glu
1025                1030                1035                1040
Glu Gly Asp Lys Gly Asp Asp Ala Ser Val Leu Thr Thr Arg Arg Asp
                1045                1050                1055    
Glu Lys Ser His Pro Phe Thr Asn Pro Arg Trp Ala Thr Arg Val Phe
            1060                1065                1070        
Ala Ala Glu Cys Val Cys Arg Ile Ile Asn Gln Cys Glu Asn Ala Asn
        1075                1080                1085            
Ser Ala His Phe Asp Ile Ala Leu Ala Gln Glu Met Lys Lys Arg Asp
    1090                1095                1100                
Ser Arg Asn Asp Phe Leu Val Leu His Leu Ala Asp Leu Ile Arg Met
1105                1110                1115                1120
Ala Phe Met Ala Ala Thr Asp His Ser Asp Gln Leu Arg Leu Ser Gly
                1125                1130                1135    
Leu Glu Met Leu Leu Val Val Ile Arg Arg Phe Ala Thr Val Pro Glu
            1140                1145                1150        
Pro Glu Phe Pro Gly His Val Ile Leu Glu Gln Tyr Gln Ala Asn Val
        1155                1160                1165            
Gly Ala Ala Leu Arg Pro Ala Phe Thr Ser Glu Thr Pro Pro Asp Val
    1170                1175                1180                
Thr Ala Lys Ala Cys Gln Val Cys Ser Ala Trp Ile Ala Ser Gly Val
1185                1190                1195                1200
Val Ser Asp Leu Asn Asp Leu Arg Arg Val His Gln Leu Leu Val Ser
                1205                1210                1215    
Ser Leu Thr Lys Ile Gln Ala Gly Lys Glu Ala Leu Ser His Leu Tyr
            1220                1225                1230        
Asn Glu Ser Ala Ser Thr Met Glu Ile Leu Ala Val Leu Lys Ala Trp
        1235                1240                1245            
Ala Glu Val Tyr Ile Ile Ala Val Gln Arg His Lys Asn His Arg Gln
    1250                1255                1260                
Pro Leu Lys Thr Thr Thr Cys Leu Glu Asp Gly Ile Arg Asn Gly Ser
1265                1270                1275                1280
Cys Ser Ser Asp Gly Leu Leu Asp Leu Val Tyr Ala Asp Leu Gly Thr
                1285                1290                1295    
Leu Ser Arg Leu Trp Leu Ala Ala Leu Gln Asp Phe Ala Leu Leu Thr
            1300                1305                1310        
Leu Pro Ser Glu Phe Ala Ser Gln Leu Pro Ala Glu Gly Gly Ala Phe
        1315                1320                1325            
Tyr Thr Ala Glu Thr Ser Glu Asn Ala Lys Leu His Tyr Tyr Asn Ser
    1330                1335                1340                
Trp Ala Leu Ile Leu His Ala Thr Ala Leu Trp Leu Thr Ser Thr Gly
1345                1350                1355                1360
Phe Val Val Ala Asp Pro Asp Glu Gly Ala Ser Asn Leu Ser Arg Pro
                1365                1370                1375    
Val Thr Pro Thr Ser Met Cys Gln Gly Ser Ser Ser Gly Ala Thr Ile
            1380                1385                1390        
Lys Ser Pro Glu Asp Val Tyr Thr Asp Arg Phe His Leu Ile Leu Gly
        1395                1400                1405            
Ile Ser Val Glu Phe Leu Cys Ser Leu Arg Ser Asp Ala Thr Met Glu
    1410                1415                1420                
Ser Ile Thr Ala Cys Leu His Ala Leu Gln Ala Leu Leu Asp Val Pro
1425                1430                1435                1440
Trp Pro Arg Ser Lys Ile Gly Ser Asp Gln Asp Leu Gly Ile Glu Leu
                1445                1450                1455    
Leu Asn Val Leu His Arg Val Ile Leu Thr Arg Glu Ser Pro Ser Ile
            1460                1465                1470        
Gln Leu Ala Ser Leu Glu Val Val Arg Gln Ile Ile Cys Ala Ala Gln
        1475                1480                1485            
Glu His Val Lys Glu Lys Arg Arg Ser Ala Glu Val Asp Asp Gly Ala
    1490                1495                1500                
Ala Glu Lys Glu Thr Leu Pro Glu Phe Gly Glu Gly Lys Asp Thr Gly
1505                1510                1515                1520
Gly Leu Val Pro Gly Lys Ser Leu Val Phe Ala Thr Leu Glu Leu Cys
                1525                1530                1535    
Val Cys Ile Leu Val Arg Gln Leu Pro Glu Leu Asn Pro Lys Leu Thr
            1540                1545                1550        
Gly Ser Pro Gly Val Lys Ala Thr Lys Pro Gln Ile Leu Leu Glu Asp
        1555                1560                1565            
Gly Ser Arg Leu Val Ser Ala Ala Leu Val Ile Leu Ser Glu Leu Pro
    1570                1575                1580                
Ala Val Cys Ser Pro Glu Gly Ser Ile Ser Ile Leu Pro Thr Ile Leu
1585                1590                1595                1600
Tyr Leu Thr Ile Gly Val Leu Arg Glu Thr Ala Val Lys Leu Pro Gly
                1605                1610                1615    
Gly Gln Leu Ser Ser Thr Val Ala Ala Ser Leu Gln Ala Leu Lys Gly
            1620                1625                1630        
Ile Leu Ser Ser Pro Met Ala Arg Ala Glu Lys Ser Arg Thr Ala Trp
        1635                1640                1645            
Thr Asp Leu Leu Arg Ser Ala Leu Thr Thr Ile Leu Asp Cys Trp Asp
    1650                1655                1660                
Pro Val Asp Glu Thr His Gln Glu Leu Asp Glu Val Ser Leu Leu Thr
1665                1670                1675                1680
Ala Ile Thr Val Phe Ile Leu Ser Thr Ser Pro Glu Val Thr Thr Ile
                1685                1690                1695    
Pro Cys Leu Gln Lys Arg Cys Ile Asp Lys Phe Lys Ala Thr Leu Glu
            1700                1705                1710        
Ile Lys Asp Pro Val Val Gln Ile Lys Thr Tyr Gln Leu Leu His Ser
        1715                1720                1725            
Ile Phe Gln Tyr Pro Asn Pro Ala Val Ser Tyr Pro Tyr Ile Tyr Ser
    1730                1735                1740                
Leu Ala Ser Cys Ile Met Glu Lys Leu Gln Glu Ile Asp Lys Arg Lys
1745                1750                1755                1760
Pro Glu Asn Thr Ala Glu Leu Glu Ile Phe Gln Glu Gly Ile Lys Val
                1765                1770                1775    
Leu Glu Thr Leu Val Thr Val Ala Glu Glu His His Arg Ala Gln Leu
            1780                1785                1790        
Val Ala Cys Leu Leu Pro Ile Leu Ile Ser Phe Leu Leu Asp Glu Asn
        1795                1800                1805            
Ser Leu Gly Ser Ala Thr Ser Ile Met Arg Asn Leu His Asp Phe Ala
    1810                1815                1820                
Leu Gln Asn Leu Met Gln Ile Gly Pro Gln Tyr Ser Ser Val Phe Lys
1825                1830                1835                1840
Ser Leu Val Ala Ser Ser Pro Ala Leu Lys Ala Arg Leu Glu Ala Ala
                1845                1850                1855    
Ile Lys Gly Asn Gln Glu Ser Val Lys Val Lys Ile Pro Thr Ser Lys
            1860                1865                1870        
Tyr Thr Lys Ser Pro Gly Lys Asn Ser Ser Ile Gln Leu Lys Thr Ser
        1875                1880                1885            
Phe Leu
    1890


<210> 7484
<211> 2071
<212> PRT
<213> Homo sapiens

<400> 7484
Met Glu Leu Ala His Ser Leu Leu Leu Asn Glu Glu Ala Leu Ala Gln
 1               5                  10                  15      
Ile Thr Glu Ala Lys Arg Pro Val Phe Ile Phe Glu Trp Leu Arg Phe
            20                  25                  30          
Leu Asp Lys Val Leu Val Ala Ala Asn Lys Thr Asp Val Lys Glu Lys
        35                  40                  45              
Gln Lys Lys Leu Val Glu Gln Leu Thr Gly Leu Ile Ser Ser Ser Pro
    50                  55                  60                  
Gly Pro Pro Thr Arg Lys Leu Leu Ala Lys Asn Leu Ala Ala Leu Tyr
65                  70                  75                  80  
Ser Ile Gly Asp Thr Phe Thr Val Phe Gln Thr Leu Asp Lys Cys Asn
                85                  90                  95      
Asp Ile Ile Arg Asn Lys Asp Asp Thr Ala Ala Tyr Leu Pro Thr Lys
            100                 105                 110         
Leu Ala Ala Val Ala Cys Val Gly Ala Phe Tyr Glu Lys Met Gly Arg
        115                 120                 125             
Met Leu Gly Ser Ala Phe Pro Glu Thr Val Asn Asn Leu Leu Lys Ser
    130                 135                 140                 
Leu Lys Ser Ala Glu Ser Gln Gly Arg Ser Glu Ile Leu Met Ser Leu
145                 150                 155                 160 
Gln Lys Val Leu Ser Gly Leu Gly Gly Ala Ala Ala Ser Ser His Arg
                165                 170                 175     
Asp Ile Tyr Lys Asn Ala Arg Ser Leu Leu Thr Asp Arg Ser Met Ala
            180                 185                 190         
Val Arg Cys Ala Val Ala Lys Cys Leu Leu Glu Leu Gln Asn Glu Ala
        195                 200                 205             
Val Phe Met Trp Thr Ala Glu Leu Glu Asn Ile Ala Thr Leu Cys Phe
    210                 215                 220                 
Lys Ala Leu Glu Asn Ser Asn Tyr Gly Val Arg Val Ala Val Ser Lys
225                 230                 235                 240 
Leu Leu Gly Thr Val Met Ala Thr Ala Leu Met Pro Lys Gln Ala Thr
                245                 250                 255     
Val Met Arg Gln Asn Val Lys Arg Ala Thr Phe Asp Glu Val Leu Glu
            260                 265                 270         
Leu Met Ala Thr Gly Phe Leu Arg Gly Gly Ser Gly Phe Leu Lys Ser
        275                 280                 285             
Gly Gly Glu Met Leu Lys Val Gly Gly Ser Val Asn Arg Glu Val Arg
    290                 295                 300                 
Val Gly Val Thr Gln Ala Tyr Val Val Phe Val Thr Thr Leu Gly Gly
305                 310                 315                 320 
Gln Trp Leu Glu Arg Ser Phe Ala Thr Phe Leu Ser His Val Leu Asp
                325                 330                 335     
Leu Val Ser His Pro Arg Ala Thr Gln Thr His Val Glu Ala Val Tyr
            340                 345                 350         
Ser Arg Arg Cys Val Ser Phe Ile Leu Arg Ala Thr Val Gly Ser Leu
        355                 360                 365             
Leu Gly Glu Lys Ala Gln Ile Ala Ala Ala Lys Glu Ile Cys Gln Ala
    370                 375                 380                 
Ile Gly Lys Gln Met Lys Ala Val Glu Ala Val Val Asn Asp Thr Ser
385                 390                 395                 400 
Gly Glu Asn Lys Ser Gly Ala Ala Asp Ile Ala Ala Ser Gln His Val
                405                 410                 415     
Met Val Cys Ala Leu Gln Glu Leu Gly Ser Leu Val Gln Ser Leu Asn
            420                 425                 430         
Ala Thr Ala Ser Pro Leu Ile Gln Glu Ala Ser Ile Gly Leu Leu Glu
        435                 440                 445             
Ile Val Thr Ser Val Leu Leu His Pro Ser Met Ala Ala Arg Leu Ala
    450                 455                 460                 
Ala Ala Trp Cys Leu Arg Cys Val Ala Val Ala Leu Pro Phe Gln Leu
465                 470                 475                 480 
Thr Pro Phe Leu Asp Arg Cys Ala Glu Arg Leu Asn Asn Leu Lys Thr
                485                 490                 495     
Ser Pro Glu Ala Val Ser Gly Tyr Ser Phe Ala Met Ala Ala Leu Leu
            500                 505                 510         
Gly Gly Val His Gln Cys Pro Leu Gly Ile Pro His Ala Lys Gly Lys
        515                 520                 525             
Met Val Val Ser Ile Ala Glu Asp Leu Leu Arg Thr Ala Ala Gln Asn
    530                 535                 540                 
Ser Arg Leu Ser Leu Gln Arg Thr Gln Ala Gly Trp Leu Leu Leu Gly
545                 550                 555                 560 
Ala Leu Met Thr Leu Gly Pro Ser Val Val Arg Tyr His Leu Pro Lys
                565                 570                 575     
Met Leu Leu Leu Trp Arg Asn Val Phe Pro Arg Ser Leu Lys Glu Leu
            580                 585                 590         
Glu Ala Glu Lys Ala Arg Gly Asp Ser Phe Thr Trp Gln Val Thr Leu
        595                 600                 605             
Glu Gly Arg Ala Gly Ala Leu Cys Ala Met Arg Ser Phe Val Ala His
    610                 615                 620                 
Cys Pro Glu Leu Leu Thr Glu Asp Val Ile Arg Lys Leu Met Thr Pro
625                 630                 635                 640 
Ile Glu Cys Ala Met Thr Met Met Ser His Ile Pro Ser Val Met Lys
                645                 650                 655     
Ala His Gly Ala His Leu Lys Ala Ser Ala Ala Met Val Arg Leu Arg
            660                 665                 670         
Leu Tyr Asp Ile Leu Ala Leu Leu Pro Pro Lys Thr Tyr Glu Gly Ser
        675                 680                 685             
Phe Asn Ala Leu Leu Arg Glu Leu Val Ala Glu Phe Thr Leu Thr Asp
    690                 695                 700                 
Asn Ser Ala Asn Thr Thr Thr Ser Leu Leu Arg Ser Leu Cys His Tyr
705                 710                 715                 720 
Asp Asp Ser Val Leu Leu Gly Ser Trp Leu Gln Glu Thr Asp His Lys
                725                 730                 735     
Ser Ile Glu Asp Gln Leu Gln Pro Asn Ser Ala Ser Gly Ser Gly Ala
            740                 745                 750         
Leu Glu His Asp Pro Ser Ser Ile Tyr Leu Arg Ile Pro Ala Gly Glu
        755                 760                 765             
Ala Val Pro Gly Pro Leu Pro Leu Gly Val Ser Val Ile Asp Ala Ser
    770                 775                 780                 
Val Ala Leu Phe Gly Val Val Phe Pro His Val Ser Tyr Lys His Arg
785                 790                 795                 800 
Leu Gln Met Leu Asp His Phe Ala Glu Cys Val Lys Gln Ala Lys Gly
                805                 810                 815     
Val Arg Gln Gln Ala Val Gln Leu Asn Ile Phe Thr Ala Val Leu Ser
            820                 825                 830         
Ala Leu Lys Gly Leu Ala Glu Asn Lys Ser Thr Leu Gly Pro Glu Glu
        835                 840                 845             
Val Arg Lys Ser Ala Leu Thr Leu Val Met Gly Pro Leu Asp Asn Pro
    850                 855                 860                 
Asn Pro Ile Leu Arg Cys Ala Ala Gly Glu Ala Leu Gly Arg Met Ala
865                 870                 875                 880 
Gln Val Val Gly Glu Ala Thr Phe Ile Ala Arg Met Ala Gln Tyr Ser
                885                 890                 895     
Phe Asp Lys Leu Lys Ser Ala Arg Asp Val Val Ser Arg Thr Gly His
            900                 905                 910         
Ser Leu Ala Leu Gly Cys Leu His Arg Tyr Val Gly Gly Ile Gly Ser
        915                 920                 925             
Gly Gln His Leu Lys Thr Ser Val Ser Ile Leu Leu Ala Leu Ala Gln
    930                 935                 940                 
Asp Gly Thr Ser Pro Glu Val Gln Thr Trp Ser Leu His Ser Leu Ala
945                 950                 955                 960 
Leu Ile Val Asp Ser Ser Gly Pro Met Tyr Arg Gly Tyr Val Glu Pro
                965                 970                 975     
Thr Leu Ser Leu Val Leu Thr Leu Leu Leu Thr Val Pro Pro Ser His
            980                 985                 990         
Thr Glu Val His Gln Cys Leu Gly Arg Cys Leu Gly Ala Ile Ile Thr
        995                 1000                1005            
Thr Val Gly Pro Glu Leu Gln Gly Asn Gly Ala Thr Thr Ser Thr Ile
    1010                1015                1020                
Arg Ser Ser Cys Leu Val Gly Cys Ala Ile Thr Gln Asp His Ser Asp
1025                1030                1035                1040
Ser Leu Val Gln Ala Ala Ala Ile Ser Cys Leu Gln Gln Leu His Met
                1045                1050                1055    
Phe Ala Pro Arg His Val Asn Leu Ser Ser Leu Val Pro Ser Leu Cys
            1060                1065                1070        
Val His Leu Cys Ser Ser His Leu Leu Leu Arg Arg Ala Ala Val Ala
        1075                1080                1085            
Cys Leu Arg Gln Leu Ala Gln Arg Glu Ala Ala Glu Val Cys Glu Tyr
    1090                1095                1100                
Ala Met Ser Leu Ala Lys Asn Thr Gly Asp Lys Glu Ser Ser Ser Ala
1105                1110                1115                1120
Asn Val Ser Pro Phe Ala Pro Gly Val Ser Ser Arg Thr Asp Ile His
                1125                1130                1135    
Cys Arg His Gln Gly Val Asn Ile Thr Glu Thr Gly Leu Glu Gly Leu
            1140                1145                1150        
Leu Phe Gly Met Leu Asp Arg Glu Thr Asp Arg Lys Leu Cys Ser Asp
        1155                1160                1165            
Ile His Asp Thr Leu Gly His Met Leu Ser Ser Leu Ala Val Glu Lys
    1170                1175                1180                
Leu Ser His Trp Leu Met Leu Cys Lys Asp Val Leu Ala Ala Ser Ser
1185                1190                1195                1200
Asp Met Ser Thr Ala Thr Leu Leu Ser Ser Gly Lys Asp Glu Glu Ala
                1205                1210                1215    
Glu Lys Lys Asp Glu Met Asp Asp Asp Thr Met Phe Thr Thr Leu Gly
            1220                1225                1230        
Glu Glu Asp Lys Ser Lys Pro Phe Val Ala Pro Arg Trp Ala Thr Arg
        1235                1240                1245            
Val Phe Ala Ala Asp Cys Leu Cys Arg Ile Ile Asn Leu Cys Glu Asn
    1250                1255                1260                
Ala Asp Gln Ala His Phe Asp Leu Ala Leu Ala Arg Ser Ala Lys Leu
1265                1270                1275                1280
Arg Asn Pro Thr Asn Asp Leu Leu Val Leu His Leu Ser Asp Leu Ile
                1285                1290                1295    
Arg Met Ala Phe Met Ala Ala Thr Asp His Ser Asn Gln Leu Arg Met
            1300                1305                1310        
Ala Gly Leu Gln Ala Leu Glu Asp Ile Ile Lys Lys Phe Ala Ser Val
        1315                1320                1325            
Pro Glu Pro Glu Phe Pro Gly His Val Ile Leu Glu Gln Tyr Gln Ala
    1330                1335                1340                
Asn Val Gly Ala Ala Leu Arg Pro Ala Phe Ser Gln Asp Thr Pro Ser
1345                1350                1355                1360
Asp Ile Ile Ala Lys Ala Cys Gln Val Cys Ser Thr Trp Ile Gly Ser
                1365                1370                1375    
Gly Val Val Ser Asp Leu Asn Asp Leu Arg Arg Val His Asn Leu Leu
            1380                1385                1390        
Val Ser Ser Leu Asp Lys Val Gln Ala Gly Lys Gly Ser Ser Ser Gln
        1395                1400                1405            
Leu Tyr Arg Glu Ser Ala Thr Thr Met Glu Lys Leu Ala Val Leu Lys
    1410                1415                1420                
Ala Trp Ala Glu Val Tyr Val Val Ala Met Asn Ile Lys Lys Glu Ala
1425                1430                1435                1440
Glu Ser Lys Pro Lys Arg Ala Ile Lys Asn Thr Asp Asp Asp Asp Asp
                1445                1450                1455    
Asp Cys Gly Thr Ile Asp Glu Leu Pro Pro Asp Ser Leu Ile Thr Leu
            1460                1465                1470        
Val Gln Pro Glu Leu Pro Thr Leu Ser Arg Leu Trp Leu Ala Ala Leu
        1475                1480                1485            
Lys Asp Tyr Ala Leu Leu Thr Leu Pro Ala Glu Phe Ser Ser Gln Leu
    1490                1495                1500                
Pro Pro Asp Gly Gly Ala Phe Tyr Thr Pro Glu Thr Ile Asp Thr Ala
1505                1510                1515                1520
Arg Leu His Tyr Arg Asn Ser Trp Ala Pro Ile Leu His Ala Val Ala
                1525                1530                1535    
Leu Trp Leu Asn Ser Thr Gly Phe Thr Cys Ser Glu Ser Thr Glu Ala
            1540                1545                1550        
Ala Ala Ile Ser Gly Leu Gln Lys Arg Ser Thr Ser Val Asn Leu Asn
        1555                1560                1565            
Gln Ala Ser Gly Ala Val Gly Ser Ala Lys Ser Leu Pro Glu Ile Asn
    1570                1575                1580                
Lys Asp Arg Met His Leu Ile Leu Gly Val Ser Ile Gln Phe Leu Cys
1585                1590                1595                1600
Ser Pro Arg Pro Glu Glu Pro Ile Glu His Val Thr Ala Cys Leu Gln
                1605                1610                1615    
Ala Leu His Thr Leu Leu Asp Ser Pro Tyr Ala Arg Val His Ile Ala
            1620                1625                1630        
Glu Asp Gln Leu Ile Gly Val Glu Leu Leu Ser Val Leu His Arg Leu
        1635                1640                1645            
Leu Leu Thr Trp Asn Pro Ser Ser Val Gln Leu Leu Val Thr Gly Val
    1650                1655                1660                
Val Gln Gln Ile Val Arg Ala Ala Gln Asp Tyr Leu Gln Glu Lys Arg
1665                1670                1675                1680
Asn Thr Leu Asn Glu Asp Asp Met Glu Lys Glu Ala Cys Thr Val Leu
                1685                1690                1695    
Gly Glu Gly Gly Asp Ser Gly Gly Leu Ile Pro Gly Lys Ser Leu Val
            1700                1705                1710        
Phe Ala Thr Met Glu Leu Leu Met Phe Ile Leu Val Arg His Met Pro
        1715                1720                1725            
His Leu Ser Thr Lys Val Ser Asp Ser Pro Ser His Ile Ala Thr Lys
    1730                1735                1740                
Thr Arg Leu Ser Glu Glu Ser Ala Arg Leu Val Ala Ala Thr Val Thr
1745                1750                1755                1760
Ile Leu Ser Asp Leu Pro Ser Leu Cys Ser Pro Ala Gly Cys Met Thr
                1765                1770                1775    
Ile Leu Pro Thr Ile Leu Phe Leu Ile Ala Arg Ile Leu Lys Asp Thr
            1780                1785                1790        
Ala Ile Lys Ser Ala Asp Asn Gln Val Pro Pro Pro Val Ser Ala Ala
        1795                1800                1805            
Leu Gln Gly Ile Lys Ser Ile Val Thr Leu Ser Met Ala Lys Thr Glu
    1810                1815                1820                
Ala Gly Val Gln Lys Gln Trp Thr Ala Leu Ile Arg Ser Thr Leu Ala
1825                1830                1835                1840
Cys Ile Leu Glu Tyr Ser Gln Pro Glu Asp Ser Val Pro Thr Pro Asp
                1845                1850                1855    
Glu Val Ser Met Leu Thr Ala Ile Ala Leu Phe Leu Trp Ser Ala Ser
            1860                1865                1870        
Asn Glu Ile Ile Gly Val Gln Ser Leu Gln Asn Gly Cys Met Asn Arg
        1875                1880                1885            
Phe Lys Asn Ala Leu Asn Ser Cys Asp Pro Trp Val Gln Ala Lys Cys
    1890                1895                1900                
Tyr Gln Leu Leu Leu Ser Val Phe Gln His Ser Asn Arg Ala Leu Ser
1905                1910                1915                1920
Thr Pro Tyr Ile His Ser Leu Ala Pro Ile Val Val Glu Lys Leu Lys
                1925                1930                1935    
Ala Val Glu Arg Asn Arg Pro Ala Ser Asn Ile Glu Leu Leu Ala Val
            1940                1945                1950        
Gln Glu Gly Ile Lys Val Leu Glu Thr Leu Val Ala Leu Gly Glu Glu
        1955                1960                1965            
Gln Asn Arg Val Gln Leu Leu Ala Leu Leu Val Pro Thr Leu Ile Ser
    1970                1975                1980                
Tyr Leu Leu Asp Glu Asn Ser Phe Ala Ser Ala Ser Ser Ala Ser Lys
1985                1990                1995                2000
Asp Leu His Glu Phe Ala Leu Gln Asn Leu Met His Ile Gly Pro Leu
                2005                2010                2015    
Tyr Pro His Ala Phe Lys Thr Val Met Gly Ala Ala Pro Glu Leu Lys
            2020                2025                2030        
Val Arg Leu Glu Thr Ala Val Arg Ala Ser Gln Ala Ser Lys Ala Lys
        2035                2040                2045            
Ala Ala Ala Arg Gln Pro Ala Pro Ala Ile His Ser Ala Pro Thr Ile
    2050                2055                2060                
Lys Leu Lys Thr Ser Phe Phe
2065                2070    


<210> 7485
<211> 684
<212> PRT
<213> Homo sapiens

<400> 7485
Met Ile Ala Gly Gln Val Ser Lys Pro Leu Leu Ser Val Arg Ser Glu
 1               5                  10                  15      
Met Asn Ala Glu Leu Arg Gly Glu Asp Lys Ala Ala Thr Ser Asp Ser
            20                  25                  30          
Glu Leu Asn Glu Pro Leu Leu Ala Pro Val Glu Ser Asn Asp Ser Glu
        35                  40                  45              
Asp Thr Pro Ser Lys Leu Phe Gly Ala Arg Gly Asn Pro Ala Leu Ser
    50                  55                  60                  
Asp Pro Gly Thr Pro Asp Gln His Gln Ala Ser Gln Thr His Pro Pro
65                  70                  75                  80  
Phe Pro Val Gly Pro Gln Pro Leu Leu Thr Ala Gln Gln Leu Ala Ser
                85                  90                  95      
Ala Val Ala Gly Val Met Pro Gly Gly Pro Pro Ala Leu Asn Gln Pro
            100                 105                 110         
Ile Leu Ile Pro Phe Asn Met Ala Gly Gln Leu Gly Gly Gln Gln Gly
        115                 120                 125             
Leu Val Leu Thr Leu Pro Thr Ala Asn Leu Thr Asn Ile Gln Gly Leu
    130                 135                 140                 
Val Ala Ala Ala Ala Ala Gly Gly Ile Met Thr Leu Pro Leu Gln Asn
145                 150                 155                 160 
Leu Gln Ala Thr Ser Ser Leu Asn Ser Gln Leu Gln Gln Leu Gln Leu
                165                 170                 175     
Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro
            180                 185                 190         
Ser Thr Asn Gln His Pro Gln Pro Ala Pro Gln Ala Pro Ser Gln Ser
        195                 200                 205             
Gln Gln Gln Pro Leu Gln Pro Thr Pro Pro Gln Gln Pro Pro Pro Ala
    210                 215                 220                 
Ser Gln Gln Pro Pro Ala Pro Thr Ser Gln Leu Gln Gln Ala Pro Gln
225                 230                 235                 240 
Pro Gln Gln His Gln Pro His Ser His Ser His Asn Gln Asn Gln Pro
                245                 250                 255     
Ser Pro Thr Gln Gln Ser Ser Ser Pro Pro Gln Lys Pro Ser Gln Ser
            260                 265                 270         
Pro Gly His Gly Leu Pro Ser Pro Leu Thr Pro Pro Asn Pro Leu Gln
        275                 280                 285             
Leu Val Asn Asn Pro Leu Ala Ser Gln Ala Ala Ala Ala Ala Ala Ala
    290                 295                 300                 
Met Ser Ser Ile Ala Ser Ser Gln Ala Phe Gly Asn Ala Leu Ser Ser
305                 310                 315                 320 
Leu Gln Gly Val Thr Gly Gln Leu Val Thr Asn Ala Gln Gly Gln Ile
                325                 330                 335     
Ile Gly Thr Ile Pro Leu Met Pro Asn Pro Gly Pro Ser Ser Gln Ala
            340                 345                 350         
Ala Ser Gly Thr Gln Gly Leu Gln Val Gln Pro Ile Thr Pro Gln Leu
        355                 360                 365             
Leu Thr Asn Ala Gln Gly Gln Ile Ile Ala Thr Val Ile Gly Asn Gln
    370                 375                 380                 
Ile Leu Pro Val Ile Asn Thr Gln Gly Ile Thr Leu Ser Pro Ile Lys
385                 390                 395                 400 
Pro Gly Gln Gln Leu His Gln Pro Ser Gln Thr Ser Val Gly Gln Ala
                405                 410                 415     
Ala Ser Gln Gly Asn Leu Leu His Leu Ala His Ser Gln Ala Ser Met
            420                 425                 430         
Ser Gln Ser Pro Val Arg Gln Ala Ser Ser Ser Ser Ser Ser Ser Ser
        435                 440                 445             
Ser Ser Ser Ala Leu Ser Val Gly Gln Leu Val Ser Asn Pro Gln Thr
    450                 455                 460                 
Ala Ala Gly Glu Val Asp Gly Val Asn Leu Glu Glu Ile Arg Glu Phe
465                 470                 475                 480 
Ala Lys Ala Phe Lys Ile Arg Arg Leu Ser Leu Gly Leu Thr Gln Thr
                485                 490                 495     
Gln Val Gly Gln Ala Leu Ser Ala Thr Glu Gly Pro Ala Tyr Ser Gln
            500                 505                 510         
Ser Ala Ile Cys Arg His Thr Ile Leu Arg Ser His Phe Phe Leu Pro
        515                 520                 525             
Gln Glu Ala Gln Glu Asn Thr Ile Ala Ser Ser Leu Thr Ala Lys Leu
    530                 535                 540                 
Asn Pro Gly Leu Leu Tyr Pro Ala Arg Phe Glu Lys Leu Asp Ile Thr
545                 550                 555                 560 
Pro Lys Ser Ala Gln Lys Ile Lys Pro Val Leu Glu Arg Trp Met Ala
                565                 570                 575     
Glu Ala Glu Ala Arg His Arg Ala Gly Met Gln Asn Leu Thr Glu Phe
            580                 585                 590         
Ile Gly Ser Glu Pro Ser Lys Lys Arg Lys Arg Arg Thr Ser Phe Thr
        595                 600                 605             
Pro Gln Ala Leu Glu Ile Leu Asn Ala His Phe Glu Lys Asn Thr His
    610                 615                 620                 
Pro Ser Gly Gln Glu Met Thr Glu Ile Ala Glu Lys Leu Asn Tyr Asp
625                 630                 635                 640 
Arg Glu Val Val Arg Val Trp Phe Cys Asn Lys Arg Gln Ala Leu Lys
                645                 650                 655     
Asn Thr Ile Lys Arg Leu Lys Gln His Glu Pro Ala Thr Ala Val Pro
            660                 665                 670         
Leu Glu Pro Leu Thr Asp Ser Leu Glu Glu Asn Ser
        675                 680                 


<210> 7486
<211> 648
<212> PRT
<213> Homo sapiens

<400> 7486
Met Ile Ala Gly Gln Val Ser Lys Pro Leu Leu Ser Val Arg Ser Glu
 1               5                  10                  15      
Met Asn Ala Glu Leu Arg Gly Glu Asp Lys Ala Ala Thr Ser Asp Ser
            20                  25                  30          
Glu Leu Asn Glu Pro Leu Leu Ala Pro Val Glu Ser Asn Asp Ser Glu
        35                  40                  45              
Asp Thr Pro Ser Lys Leu Phe Gly Ala Arg Gly Asn Pro Ala Leu Ser
    50                  55                  60                  
Asp Pro Gly Thr Pro Asp Gln His Gln Ala Ser Gln Thr His Pro Pro
65                  70                  75                  80  
Phe Pro Val Gly Pro Gln Pro Leu Leu Thr Ala Gln Gln Leu Ala Ser
                85                  90                  95      
Ala Val Ala Gly Val Met Pro Gly Gly Pro Pro Ala Leu Asn Gln Pro
            100                 105                 110         
Ile Leu Ile Pro Phe Asn Met Ala Gly Gln Leu Gly Gly Gln Gln Gly
        115                 120                 125             
Leu Val Leu Thr Leu Pro Thr Ala Asn Leu Thr Asn Ile Gln Gly Leu
    130                 135                 140                 
Val Ala Ala Ala Ala Ala Gly Gly Ile Met Thr Leu Pro Leu Gln Asn
145                 150                 155                 160 
Leu Gln Ala Thr Ser Ser Leu Asn Ser Gln Leu Gln Gln Leu Gln Leu
                165                 170                 175     
Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro
            180                 185                 190         
Ser Thr Asn Gln His Pro Gln Pro Ala Pro Gln Ala Pro Ser Gln Ser
        195                 200                 205             
Gln Gln Gln Pro Leu Gln Pro Thr Pro Pro Gln Gln Pro Pro Pro Ala
    210                 215                 220                 
Ser Gln Gln Pro Pro Ala Pro Thr Ser Gln Leu Gln Gln Ala Pro Gln
225                 230                 235                 240 
Pro Gln Gln His Gln Pro His Ser His Ser His Asn Gln Asn Gln Pro
                245                 250                 255     
Ser Pro Thr Gln Gln Ser Ser Ser Pro Pro Gln Lys Pro Ser Gln Ser
            260                 265                 270         
Pro Gly His Gly Leu Pro Ser Pro Leu Thr Pro Pro Asn Pro Leu Gln
        275                 280                 285             
Leu Val Asn Asn Pro Leu Ala Ser Gln Ala Ala Ala Ala Ala Ala Ala
    290                 295                 300                 
Met Ser Ser Ile Ala Ser Ser Gln Ala Phe Gly Asn Ala Leu Ser Ser
305                 310                 315                 320 
Leu Gln Gly Val Thr Gly Gln Leu Val Thr Asn Ala Gln Gly Gln Ile
                325                 330                 335     
Ile Gly Thr Ile Pro Leu Met Pro Asn Pro Gly Pro Ser Ser Gln Ala
            340                 345                 350         
Ala Ser Gly Thr Gln Gly Leu Gln Val Gln Pro Ile Thr Pro Gln Leu
        355                 360                 365             
Leu Thr Asn Ala Gln Gly Gln Ile Ile Ala Thr Val Ile Gly Asn Gln
    370                 375                 380                 
Ile Leu Pro Val Ile Asn Thr Gln Gly Ile Thr Leu Ser Pro Ile Lys
385                 390                 395                 400 
Pro Gly Gln Gln Leu His Gln Pro Ser Gln Thr Ser Val Gly Gln Ala
                405                 410                 415     
Ala Ser Gln Gly Asn Leu Leu His Leu Ala His Ser Gln Ala Ser Met
            420                 425                 430         
Ser Gln Ser Pro Val Arg Gln Ala Ser Ser Ser Ser Ser Ser Ser Ser
        435                 440                 445             
Ser Ser Ser Ala Leu Ser Val Gly Gln Leu Val Ser Asn Pro Gln Thr
    450                 455                 460                 
Ala Ala Gly Glu Val Asp Gly Val Asn Leu Glu Glu Ile Arg Glu Phe
465                 470                 475                 480 
Ala Lys Ala Phe Lys Ile Arg Arg Leu Ser Leu Gly Leu Thr Gln Thr
                485                 490                 495     
Gln Val Gly Gln Ala Leu Ser Ala Thr Glu Gly Pro Ala Tyr Ser Gln
            500                 505                 510         
Ser Ala Ile Cys Arg Phe Glu Lys Leu Asp Ile Thr Pro Lys Ser Ala
        515                 520                 525             
Gln Lys Ile Lys Pro Val Leu Glu Arg Trp Met Ala Glu Ala Glu Ala
    530                 535                 540                 
Arg His Arg Ala Gly Met Gln Asn Leu Thr Glu Phe Ile Gly Ser Glu
545                 550                 555                 560 
Pro Ser Lys Lys Arg Lys Arg Arg Thr Ser Phe Thr Pro Gln Ala Leu
                565                 570                 575     
Glu Ile Leu Asn Ala His Phe Glu Lys Asn Thr His Pro Ser Gly Gln
            580                 585                 590         
Glu Met Thr Glu Ile Ala Glu Lys Leu Asn Tyr Asp Arg Glu Val Val
        595                 600                 605             
Arg Val Trp Phe Cys Asn Lys Arg Gln Ala Leu Lys Asn Thr Ile Lys
    610                 615                 620                 
Arg Leu Lys Gln His Glu Pro Ala Thr Ala Val Pro Leu Glu Pro Leu
625                 630                 635                 640 
Thr Asp Ser Leu Glu Glu Asn Ser
                645             


<210> 7487
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 7487
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu
 1               5                  10                  15      
Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly
            20                  25                  30          
Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser
        35                  40                  45              
Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe
    50                  55                  60                  
Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys
65                  70                  75                  80  
Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala
                85                  90                  95      
Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln
            100                 105                 110         
Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu
        115                 120                 125             
Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu
    130                 135                 140                 
Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile
145                 150                 155                 160 
Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His
                165                 170                 175     
Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg
            180                 185                 190         
Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr
        195                 200                 205             
Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser
    210                 215                 220                 
Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys
225                 230                 235                 240 
Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp
                245                 250                 255     
Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile
            260                 265                 270         
Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg
        275                 280                 285             
Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser
    290                 295                 300                 
Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro
305                 310                 315                 320 
Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln
                325                 330                 335     
Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val
            340                 345                 350         
Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu
        355                 360                 365             
Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu
    370                 375                 380                 
Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr
385                 390                 395                 400 
Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn
                405                 410                 415     
Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp
            420                 425                 430         
Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu
        435                 440                 445             
Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala
    450                 455                 460                 
Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr
465                 470                 475                 480 
Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala
                485                 490                 495     
Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr
            500                 505                 510         
Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr
        515                 520                 525             
Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu
    530                 535                 540                 
Gln Pro Lys Thr Pro Gln Gly Arg Gln Val Asp Ala Asp Thr Lys Ala
545                 550                 555                 560 
Gly Arg Lys Gly Lys Glu Leu Asp Asp Leu Val Pro Glu Thr Ala Lys
                565                 570                 575     
Gly Lys Pro Glu Leu Gln Thr Ser Ala Ser Gln Gln Met Leu Asn Phe
            580                 585                 590         
Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly Leu
        595                 600                 605             
Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys Ala
    610                 615                 620                 
Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu Leu
625                 630                 635                 640 
Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser Glu
                645                 650                 655     
His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu Arg
            660                 665                 670         
Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu Gly
        675                 680                 685             
Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro Val
    690                 695                 700                 
Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val Ala
705                 710                 715                 720 
Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys Glu
                725                 730                 735     
Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu Glu
            740                 745                 750         
Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu Ser
        755                 760                 765             
Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu Glu
    770                 775                 780                 
Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu Lys
785                 790                 795                 800 
Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu Glu
                805                 810                 815     
Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys Gly
            820                 825                 830         
Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp Pro
        835                 840                 845             
Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu Glu
    850                 855                 860                 
Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys Val
865                 870                 875                 880 
Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala Ala
                885                 890                 895     
Leu Ala Ala Ala Ala Val Lys Ala Lys His Phe Ala Ala Val Glu Glu
            900                 905                 910         
Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met Lys
        915                 920                 925             
Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile Met
    930                 935                 940                 
Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu Ala
945                 950                 955                 960 
Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met Arg
                965                 970                 975     
Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln Pro
            980                 985                 990         
Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly Ala
        995                 1000                1005            
Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser Val
    1010                1015                1020                
Val Pro Ala Pro Ala Gly Ser Gly Ala Pro Pro Gly Ser Leu Gly Pro
1025                1030                1035                1040
Ser Glu Gln Ile Gly Gln Ala Gly Ser Thr Ala Gly Pro Gln Gln Gln
                1045                1050                1055    
Gln Pro Ala Gly Ala Pro Gln Pro Gly Ala Val Pro Pro Gly Val Pro
            1060                1065                1070        
Pro Pro Gly Pro His Gly Pro Ser Pro Phe Pro Asn Gln Gln Thr Pro
        1075                1080                1085            
Pro Ser Met Met Pro Gly Ala Val Pro Gly Ser Gly His Pro Gly Val
    1090                1095                1100                
Ala Asp Pro Gly Thr Pro Leu Pro Pro Asp Pro Thr Ala Pro Ser Pro
1105                1110                1115                1120
Gly Thr Val Thr Pro Val Pro Pro Pro Gln
                1125                1130


<210> 7488
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 7488
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu
 1               5                  10                  15      
Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly
            20                  25                  30          
Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser
        35                  40                  45              
Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe
    50                  55                  60                  
Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys
65                  70                  75                  80  
Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala
                85                  90                  95      
Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln
            100                 105                 110         
Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu
        115                 120                 125             
Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu
    130                 135                 140                 
Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile
145                 150                 155                 160 
Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His
                165                 170                 175     
Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg
            180                 185                 190         
Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr
        195                 200                 205             
Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser
    210                 215                 220                 
Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys
225                 230                 235                 240 
Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp
                245                 250                 255     
Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile
            260                 265                 270         
Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg
        275                 280                 285             
Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser
    290                 295                 300                 
Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro
305                 310                 315                 320 
Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln
                325                 330                 335     
Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val
            340                 345                 350         
Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu
        355                 360                 365             
Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu
    370                 375                 380                 
Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr
385                 390                 395                 400 
Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn
                405                 410                 415     
Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp
            420                 425                 430         
Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu
        435                 440                 445             
Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala
    450                 455                 460                 
Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr
465                 470                 475                 480 
Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala
                485                 490                 495     
Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr
            500                 505                 510         
Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr
        515                 520                 525             
Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu
    530                 535                 540                 
Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn
545                 550                 555                 560 
Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly
                565                 570                 575     
Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys
            580                 585                 590         
Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu
        595                 600                 605             
Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser
    610                 615                 620                 
Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu
625                 630                 635                 640 
Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu
                645                 650                 655     
Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro
            660                 665                 670         
Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val
        675                 680                 685             
Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys
    690                 695                 700                 
Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu
705                 710                 715                 720 
Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu
                725                 730                 735     
Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu
            740                 745                 750         
Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu
        755                 760                 765             
Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu
    770                 775                 780                 
Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys
785                 790                 795                 800 
Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp
                805                 810                 815     
Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu
            820                 825                 830         
Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys
        835                 840                 845             
Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala
    850                 855                 860                 
Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu
865                 870                 875                 880 
Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met
                885                 890                 895     
Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile
            900                 905                 910         
Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu
        915                 920                 925             
Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met
    930                 935                 940                 
Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln
945                 950                 955                 960 
Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly
                965                 970                 975     
Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser
            980                 985                 990         
Val Val Pro Ala Pro Ala Gly Ser Gly Ala Pro Pro Gly Ser Leu Gly
        995                 1000                1005            
Pro Ser Glu Gln Ile Gly Gln Ala Gly Ser Thr Ala Gly Pro Gln Gln
    1010                1015                1020                
Gln Gln Pro Ala Gly Ala Pro Gln Pro Gly Ala Val Pro Pro Gly Val
1025                1030                1035                1040
Pro Pro Pro Gly Pro His Gly Pro Ser Pro Phe Pro Asn Gln Gln Thr
                1045                1050                1055    
Pro Pro Ser Met Met Pro Gly Ala Val Pro Gly Ser Gly His Pro Gly
            1060                1065                1070        
Val Ala Gly Asn Ala Pro Leu Gly Leu Pro Phe Gly Met Pro Pro Pro
        1075                1080                1085            
Pro Pro Pro Pro Ala Pro Ser Ile Ile Pro Phe Gly Ser Leu Ala Asp
    1090                1095                1100                
Ser Ile Ser Ile Asn Leu Pro Ala Pro Pro Asn Leu His Gly His His
1105                1110                1115                1120
His His Leu Pro Phe Ala Pro Gly Thr Leu Pro Pro Pro Asn Leu Pro
                1125                1130                1135    
Val Ser Met Ala Asn Pro Leu His Pro Asn Leu Pro Ala Thr Thr Thr
            1140                1145                1150        
Met Pro Ser Ser Leu Pro Leu Gly Pro Gly Leu Gly Ser Ala Ala Ala
        1155                1160                1165            
Gln Ser Pro Ala Ile Val Ala Ala Val Gln Gly Asn Leu Leu Pro Ser
    1170                1175                1180                
Ala Ser Pro Leu Pro Asp Pro Gly Thr Pro Leu Pro Pro Asp Pro Thr
1185                1190                1195                1200
Ala Pro Ser Pro Gly Thr Val Thr Pro Val Pro Pro Pro Gln
                1205                1210                


<210> 7489
<211> 450
<212> PRT
<213> Homo sapiens

<400> 7489
Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile
 1               5                  10                  15      
Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr
            20                  25                  30          
Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro
        35                  40                  45              
Glu Val Glu Pro Asp Leu Gly Glu Lys Ala Ile Glu Ser Ala Pro Glu
    50                  55                  60                  
Lys Arg Leu Thr Leu Ala Gln Ile Tyr Glu Trp Met Val Arg Thr Val
65                  70                  75                  80  
Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys
                85                  90                  95      
Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile Lys Val
            100                 105                 110         
His Asn Glu Ala Thr Gly Lys Ser Ser Trp Trp Met Leu Asn Pro Glu
        115                 120                 125             
Gly Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Ala Ser Met Asp
    130                 135                 140                 
Ser Ser Ser Lys Leu Leu Arg Gly Arg Ser Lys Ala Pro Lys Lys Lys
145                 150                 155                 160 
Pro Ser Val Leu Pro Ala Pro Pro Glu Gly Ala Thr Pro Thr Ser Pro
                165                 170                 175     
Val Gly His Phe Ala Lys Trp Ser Gly Ser Pro Cys Ser Arg Asn Arg
            180                 185                 190         
Glu Glu Ala Asp Met Trp Thr Thr Phe Arg Pro Arg Ser Ser Ser Asn
        195                 200                 205             
Ala Ser Ser Val Ser Thr Arg Leu Ser Pro Leu Arg Pro Glu Ser Glu
    210                 215                 220                 
Val Leu Ala Glu Glu Ile Pro Ala Ser Val Ser Ser Tyr Ala Gly Gly
225                 230                 235                 240 
Val Pro Pro Thr Leu Asn Glu Gly Leu Glu Leu Leu Asp Gly Leu Asn
                245                 250                 255     
Leu Thr Ser Ser His Ser Leu Leu Ser Arg Ser Gly Leu Ser Gly Phe
            260                 265                 270         
Ser Leu Gln His Pro Gly Val Thr Gly Pro Leu His Thr Tyr Ser Ser
        275                 280                 285             
Ser Leu Phe Ser Pro Ala Glu Gly Pro Leu Ser Ala Gly Glu Gly Cys
    290                 295                 300                 
Phe Ser Ser Ser Gln Ala Leu Glu Ala Leu Leu Thr Ser Asp Thr Pro
305                 310                 315                 320 
Pro Pro Pro Ala Asp Val Leu Met Thr Gln Val Asp Pro Ile Leu Ser
                325                 330                 335     
Gln Ala Pro Thr Leu Leu Leu Leu Gly Gly Leu Pro Ser Ser Ser Lys
            340                 345                 350         
Leu Ala Thr Gly Val Gly Leu Cys Pro Lys Pro Leu Glu Ala Arg Gly
        355                 360                 365             
Pro Ser Ser Leu Val Pro Thr Leu Ser Met Ile Ala Pro Pro Pro Val
    370                 375                 380                 
Met Ala Ser Ala Pro Ile Pro Lys Ala Leu Gly Thr Pro Val Leu Thr
385                 390                 395                 400 
Pro Pro Thr Glu Ala Ala Ser Gln Asp Arg Met Pro Gln Asp Leu Asp
                405                 410                 415     
Leu Asp Met Tyr Met Glu Asn Leu Glu Cys Asp Met Asp Asn Ile Ile
            420                 425                 430         
Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp Phe Asn Phe Glu Pro
        435                 440                 445             
Asp Pro
    450 


<210> 7490
<211> 191
<212> PRT
<213> Homo sapiens

<400> 7490
Leu Leu His Ile Val Ser Leu His Pro Ala Thr Cys Pro Arg Val Pro
 1               5                  10                  15      
Leu Ser Pro Leu Pro Gln Gly Arg Arg Arg Arg Arg His Gln Ser Ala
            20                  25                  30          
Gly Tyr Gln Pro Leu Pro Arg Gly Pro Arg Ala Gln Asn Arg Lys Ala
        35                  40                  45              
Ile Val Asp Lys Phe Gly Gly Ala Ala Ser Gly Pro Thr Ala Leu Phe
    50                  55                  60                  
Arg Asn Thr Lys Ala Ala Gly Ala Ala Ile Gly Gly Val Lys Asn Met
65                  70                  75                  80  
Leu Leu Glu Trp Cys Arg Ala Met Thr Lys Lys Tyr Glu His Val Asp
                85                  90                  95      
Ile Gln Asn Phe Ser Ser Ser Trp Ser Ser Gly Met Ala Phe Cys Ala
            100                 105                 110         
Leu Ile His Lys Phe Phe Pro Asp Ala Phe Asp Tyr Ala Glu Leu Asp
        115                 120                 125             
Pro Ala Lys Arg Arg His Asn Phe Thr Leu Ala Phe Ser Thr Ala Glu
    130                 135                 140                 
Lys Leu Ala Asp Cys Ala Gln Leu Leu Asp Val Asp Asp Met Val Arg
145                 150                 155                 160 
Leu Ala Val Pro Asp Ser Lys Cys Val Tyr Thr Tyr Ile Gln Glu Leu
                165                 170                 175     
Tyr Arg Ser Leu Val Gln Lys Gly Leu Val Lys Thr Lys Lys Lys
            180                 185                 190     


<210> 7491
<211> 514
<212> PRT
<213> Homo sapiens

<400> 7491
Met Glu Gln Lys Glu Gly Lys Leu Ser Glu Asp Gly Thr Thr Val Ser
 1               5                  10                  15      
Pro Ala Ala Asp Asn Pro Glu Met Ser Gly Gly Gly Ala Pro Ala Glu
            20                  25                  30          
Glu Thr Lys Gly Thr Ala Gly Lys Ala Ile Asn Glu Gly Pro Pro Thr
        35                  40                  45              
Glu Ser Gly Lys Gln Glu Lys Ala Pro Ala Glu Asp Gly Met Ser Ala
    50                  55                  60                  
Glu Leu Gln Gly Glu Ala Asn Gly Leu Asp Glu Val Lys Val Glu Ser
65                  70                  75                  80  
Gln Arg Glu Ala Gly Gly Lys Glu Asp Ala Glu Ala Glu Leu Lys Lys
                85                  90                  95      
Glu Asp Gly Glu Lys Glu Glu Thr Thr Val Gly Ser Gln Glu Met Thr
            100                 105                 110         
Gly Arg Lys Glu Glu Thr Lys Ser Glu Pro Lys Glu Ala Glu Glu Lys
        115                 120                 125             
Glu Ser Thr Leu Ala Ser Glu Lys Gln Lys Ala Glu Glu Lys Glu Ala
    130                 135                 140                 
Lys Pro Glu Ser Gly Gln Lys Ala Asp Ala Asn Asp Arg Asp Lys Pro
145                 150                 155                 160 
Glu Pro Lys Ala Thr Val Glu Glu Glu Asp Ala Lys Thr Ala Ser Gln
                165                 170                 175     
Glu Glu Thr Gly Gln Arg Lys Glu Cys Ser Thr Glu Pro Lys Glu Lys
            180                 185                 190         
Ala Thr Asp Glu Glu Ala Lys Ala Glu Ser Gln Lys Ala Val Val Glu
        195                 200                 205             
Asp Glu Ala Lys Ala Glu Pro Lys Glu Pro Asp Gly Lys Glu Glu Ala
    210                 215                 220                 
Lys His Gly Ala Lys Glu Glu Ala Asp Ala Lys Glu Glu Ala Glu Asp
225                 230                 235                 240 
Ala Glu Glu Ala Glu Pro Gly Ser Pro Ser Glu Glu Gln Glu Gln Asp
                245                 250                 255     
Val Glu Lys Glu Pro Glu Gly Gly Ala Gly Val Ile Pro Ser Ser Pro
            260                 265                 270         
Glu Glu Trp Pro Glu Ser Pro Thr Gly Glu Gly His Asn Leu Ser Thr
        275                 280                 285             
Asp Gly Leu Gly Pro Asp Cys Val Ala Ser Gly Gln Thr Ser Pro Ser
    290                 295                 300                 
Ala Ser Glu Ser Ser Pro Ser Asp Val Pro Gln Ser Pro Pro Glu Ser
305                 310                 315                 320 
Pro Ser Ser Gly Glu Lys Lys Glu Lys Ala Pro Glu Arg Arg Val Ser
                325                 330                 335     
Ala Pro Ala Arg Pro Arg Gly Pro Arg Ala Gln Asn Arg Lys Ala Ile
            340                 345                 350         
Val Asp Lys Phe Gly Gly Gly Ala Leu His Gly Leu Leu Pro Leu Trp
        355                 360                 365             
Leu Gly Leu Ala Pro Leu Ser Pro His Arg Ala Ala Ser Gly Pro Thr
    370                 375                 380                 
Ala Leu Phe Arg Asn Thr Lys Ala Ala Gly Ala Ala Ile Gly Gly Val
385                 390                 395                 400 
Lys Asn Met Leu Leu Glu Trp Cys Arg Ala Met Thr Lys Lys Tyr Glu
                405                 410                 415     
His Val Asp Ile Gln Asn Phe Ser Ser Ser Trp Ser Ser Gly Met Ala
            420                 425                 430         
Phe Cys Ala Leu Ile His Lys Phe Phe Pro Asp Ala Phe Asp Tyr Ala
        435                 440                 445             
Glu Leu Asp Pro Ala Lys Arg Arg His Asn Phe Thr Leu Ala Phe Ser
    450                 455                 460                 
Thr Ala Glu Lys Leu Ala Asp Cys Ala Gln Leu Leu Asp Val Asp Asp
465                 470                 475                 480 
Met Val Arg Leu Ala Val Pro Asp Ser Lys Cys Val Tyr Thr Tyr Ile
                485                 490                 495     
Gln Glu Leu Tyr Arg Ser Leu Val Gln Lys Gly Leu Val Lys Thr Lys
            500                 505                 510         
Lys Lys
        


<210> 7492
<211> 1445
<212> PRT
<213> Homo sapiens

<400> 7492
Met Gly Asn Leu Val Ile Pro Leu Gly Lys Gly Arg Ala Gly Arg Val
 1               5                  10                  15      
Glu Ser Gly Gln Arg Ile Pro Pro Pro Ala Pro Arg Pro Ser Val Glu
            20                  25                  30          
Cys Thr Gly Asp Asp Ile Ala Leu Gln Met Glu Lys Met Leu Phe Pro
        35                  40                  45              
Leu Lys Ser Pro Ser Ala Thr Trp Leu Ser Pro Ser Ser Thr Pro Trp
    50                  55                  60                  
Met Met Asp Phe Ile Leu Thr Ser Val Cys Gly Leu Val Leu Leu Phe
65                  70                  75                  80  
Leu Leu Leu Leu Tyr Val His Ser Asp Pro Pro Ser Pro Pro Pro Gly
                85                  90                  95      
Arg Lys Arg Ser Ser Arg Glu Pro Gln Arg Glu Arg Ser Gly Arg Ser
            100                 105                 110         
Arg Ser Arg Lys Ile Ser Ala Leu Lys Ala Cys Arg Ile Leu Leu Arg
        115                 120                 125             
Glu Leu Glu Glu Thr Arg Asp Leu Asn Tyr Leu Leu Glu Ser His Leu
    130                 135                 140                 
Arg Lys Leu Ala Gly Glu Gly Ser Ser His Leu Pro Leu Gly Gly Asp
145                 150                 155                 160 
Pro Leu Gly Asp Val Cys Lys Pro Val Pro Ala Lys Ala His Gln Pro
                165                 170                 175     
His Gly Lys Cys Met Gln Asp Pro Ser Pro Ala Ser Leu Ser Pro Pro
            180                 185                 190         
Ala Pro Pro Ala Pro Leu Ala Ser Thr Leu Ser Pro Gly Pro Met Thr
        195                 200                 205             
Phe Ser Glu Pro Phe Gly Pro His Ser Thr Leu Ser Ala Ser Gly Pro
    210                 215                 220                 
Pro Glu Pro Leu Leu Pro Leu Lys Cys Pro Ala Thr Gln Pro His Val
225                 230                 235                 240 
Val Phe Pro Pro Ser Pro Gln Pro His Gly Pro Leu Ala Ser Ser Pro
                245                 250                 255     
Pro Pro Pro Asp Ser Ser Leu Ala Gly Leu Gln Cys Gly Ser Thr Thr
            260                 265                 270         
Cys Pro Val Pro Gln Ser Ser Pro Leu His Asn Gln Val Leu Pro Pro
        275                 280                 285             
Pro Thr Arg Val Ile Ser Gly Leu Gly Cys Ser Ser Asp Pro Ile Trp
    290                 295                 300                 
Asp Leu Tyr Cys Trp Arg Glu Ala Ala Thr Thr Trp Gly Leu Ser Thr
305                 310                 315                 320 
Tyr Ser His Gly Lys Ser Gln Pro Arg His Leu Pro Asp His Pro Ser
                325                 330                 335     
Glu Ala Ser Phe Trp Gly Asp Pro Thr Pro Lys His Met Glu Val Gly
            340                 345                 350         
Gly Cys Thr Phe Ile His Pro Asp Val Gln Lys Leu Leu Glu Thr Leu
        355                 360                 365             
Ile Ala Lys Arg Ala Leu Met Lys Met Trp Gln Glu Lys Glu Arg Lys
    370                 375                 380                 
Arg Ala Asp His Pro His Met Thr Ser Leu Gly Lys Glu Trp Asp Ile
385                 390                 395                 400 
Thr Thr Leu Asn Pro Phe Trp Asn Val Ser Thr Gln Pro Gln Gln Leu
                405                 410                 415     
Pro Arg Pro Gln Gln Val Ser Asp Ala Thr Thr Val Gly Asn His Leu
            420                 425                 430         
Gln Gln Lys Arg Ser Gln Leu Phe Trp Asp Leu Pro Ser Leu Asn Ser
        435                 440                 445             
Glu Ser Leu Ala Thr Thr Val Trp Val Ser Arg Asn Pro Ser Ser Gln
    450                 455                 460                 
Asn Ala His Ser Val Pro Leu Asp Lys Ala Ser Thr Ser Leu Pro Gly
465                 470                 475                 480 
Glu Pro Glu Val Glu Ala Ser Ser Gln Leu Ser Gln Ala Pro Pro Gln
                485                 490                 495     
Pro His His Met Ala Gln Pro Gln His Phe Thr Pro Ala Trp Pro Gln
            500                 505                 510         
Ser Gln Pro Pro Pro Leu Ala Glu Ile Gln Thr Gln Ala His Leu Ser
        515                 520                 525             
Pro Pro Val Pro Ser Leu Gly Cys Ser Ser Pro Pro Gln Ile Arg Gly
    530                 535                 540                 
Cys Gly Ala Ser Tyr Pro Thr Ser Gln Glu Arg Thr Gln Ser Val Ile
545                 550                 555                 560 
Pro Thr Gly Lys Glu Tyr Leu Glu Trp Pro Leu Lys Lys Arg Pro Lys
                565                 570                 575     
Trp Lys Arg Val Leu Pro Ser Leu Leu Lys Lys Ser Gln Ala Val Leu
            580                 585                 590         
Ser Gln Pro Thr Ala His Leu Pro Gln Glu Arg Pro Ala Ser Trp Ser
        595                 600                 605             
Pro Lys Ser Ala Pro Ile Leu Pro Gly Val Val Thr Ser Pro Glu Leu
    610                 615                 620                 
Pro Glu His Trp Trp Gln Gly Arg Asn Ala Ile His Gln Glu Gln Ser
625                 630                 635                 640 
Cys Gly Pro Pro Ser Arg Leu Gln Ala Ser Gly Asp Leu Leu Gln Pro
                645                 650                 655     
Asp Gly Glu Phe Pro Gly Arg Pro Gln Ser Gln Ala Glu Asp Thr Gln
            660                 665                 670         
Gln Ala Leu Leu Pro Ser Gln Pro Ser Glu Phe Ala Gly Lys Gly Arg
        675                 680                 685             
Lys Asp Val Gln Lys Thr Gly Phe Arg Ser Ser Gly Arg Phe Ser Asp
    690                 695                 700                 
Lys Gly Cys Leu Gly Ser Lys Leu Gly Pro Asp Pro Ser Arg Asp Gln
705                 710                 715                 720 
Gly Ser Gly Arg Thr Ser Val Lys Ala Leu Asp Glu Asp Lys Glu Ala
                725                 730                 735     
Glu Gly Asp Leu Arg Arg Ser Trp Lys Tyr Gln Ser Val Ser Ser Thr
            740                 745                 750         
Pro Arg Asp Pro Asp Lys Glu His Leu Glu Asn Lys Leu Gln Ile His
        755                 760                 765             
Leu Ala Arg Lys Val Gly Glu Ile Lys Glu Gly Trp Ile Pro Met Pro
    770                 775                 780                 
Val Arg Arg Ser Trp Leu Met Ala Lys Cys Ala Val Pro Lys Ser Asp
785                 790                 795                 800 
Thr His Arg Lys Pro Glu Lys Leu Ala Ser Trp Arg Gly Gly Lys Ala
                805                 810                 815     
His Val Asn Thr Ser Gln Glu Leu Ser Phe Leu His Pro Cys Thr Gln
            820                 825                 830         
Gln Ile Leu Glu Val His Leu Val Arg Phe Cys Val Arg His Ser Trp
        835                 840                 845             
Gly Thr Asp Leu Gln Ser Leu Glu Pro Ile Asn Val Trp Ser Gly Glu
    850                 855                 860                 
Ala Gln Ala Pro Pro Phe Pro Gln Ser Thr Phe Thr Pro Trp Ala Ser
865                 870                 875                 880 
Trp Val Ser Arg Val Glu Ser Val Pro Lys Val Pro Ile Phe Leu Gly
                885                 890                 895     
Lys Arg Pro Gln Ser Gly Pro Gly Asp Asn Arg Thr Thr Ser Lys Ser
            900                 905                 910         
Val Pro Thr Val Ser Gly Pro Leu Ala Ala Pro Pro Pro Glu Gln Glu
        915                 920                 925             
Gly Val Gln Arg Pro Pro Arg Gly Ser Gln Ser Ala Asp Thr His Gly
    930                 935                 940                 
Arg Ser Glu Ala Phe Pro Thr Gly His Lys Gly Arg Gly Cys Ser Gln
945                 950                 955                 960 
Pro Pro Thr Cys Ser Leu Val Gly Arg Thr Trp Gln Ser Arg Thr Val
                965                 970                 975     
Leu Glu Ser Gly Lys Pro Lys Pro Arg Leu Glu Gly Ser Met Gly Ser
            980                 985                 990         
Glu Met Ala Gly Asn Glu Ala Trp Leu Glu Ser Glu Ser Met Ser Pro
        995                 1000                1005            
Gly Asp Pro Cys Ser Ser Arg Ala Leu Gln Glu Leu Ser Ile Gly Ser
    1010                1015                1020                
Gln Trp Ala Arg Ala Glu Asp Ala Leu Gln Ala Leu Lys Val Gly Glu
1025                1030                1035                1040
Lys Pro Pro Thr Trp Glu Val Thr Leu Gly Ala Ser Val Arg Ala Ser
                1045                1050                1055    
Ser Gly Ser Val Gln Glu Asp Leu Arg Ser Thr Gly Ala Leu Gly Thr
            1060                1065                1070        
Thr Gly Asn Pro Ser Ala Ser Ser Val Cys Val Ala Gln Asp Pro Glu
        1075                1080                1085            
Gln Leu His Leu Lys Ala Gln Val Val Ser Glu Ile Ala Leu Ile Val
    1090                1095                1100                
Gln Val Asp Ser Glu Glu Gln Leu Pro Gly Arg Ala Pro Gly Ile Leu
1105                1110                1115                1120
Leu Gln Asp Gly Ala Thr Gly Leu Cys Leu Pro Gly Arg His Met Asp
                1125                1130                1135    
Met Leu Thr Ala Ala Asp Arg Leu Pro Thr Gln Ala Pro Leu Ser Thr
            1140                1145                1150        
Ser Gln Ser Val Ser Gly Lys Asn Met Thr Ala Ser Gln Gly Pro Cys
        1155                1160                1165            
Ala Leu Leu Trp Lys Gly Gly Asp Ser Pro Gly Gln Gln Glu Pro Gly
    1170                1175                1180                
Ser Pro Lys Ala Lys Ala Pro Gln Lys Ser Gln Lys Thr Leu Gly Cys
1185                1190                1195                1200
Ala Gly Lys Gly Glu Ala His Arg Arg Pro Arg Thr Gly Glu Gln Gly
                1205                1210                1215    
His Arg Ser Lys Gly Pro Arg Thr Ser Glu Ala Ser Gly Arg Ser His
            1220                1225                1230        
Pro Ala Gln Ala Arg Glu Ile Gly Asp Lys Gln Glu Arg Lys Tyr Asn
        1235                1240                1245            
Gln Leu Gln Leu Glu Lys Gly Gln Thr Pro Pro Glu Ser His Phe Gln
    1250                1255                1260                
Arg Lys Ile Ser His His Pro Gln Gly Leu His Pro Arg Lys Gly Gly
1265                1270                1275                1280
Thr Arg Trp Glu Asp Val Leu Gln Lys Gly Lys Pro Gly Ala Asp Ala
                1285                1290                1295    
Phe Gln Ser Trp Gly Ser Gly Pro Pro Arg Gln Phe Met Asp Cys Met
            1300                1305                1310        
Ala Asp Lys Ala Trp Thr Ile Ser Arg Val Val Gly Gln Ile Leu Val
        1315                1320                1325            
Asp Lys Leu Gly Leu Gln Trp Gly Arg Gly Pro Ser Glu Val Asn Arg
    1330                1335                1340                
His Lys Gly Asp Phe His Ala Gln Glu Asn Val Pro Ser Cys Cys His
1345                1350                1355                1360
Arg Gly His Cys His Gln Glu Arg Ser Arg Glu Met Arg Ala Leu Ala
                1365                1370                1375    
Cys Ser Pro Lys Ala Thr Pro Lys Gly His His Cys Pro Val Lys Asn
            1380                1385                1390        
Arg Gly Ile Arg Asp Arg Asp Ser Ser Trp Ala Pro Pro Pro Arg Glu
        1395                1400                1405            
Pro Val Ser Pro Ala Gly Pro His His His Arg Pro Arg Met Ala Ser
    1410                1415                1420                
Thr Ser Gly Gly Pro His Pro Gln Leu Gln Glu Leu Met Ser Ala Gln
1425                1430                1435                1440
Arg Cys Leu Ala Ser
                1445


<210> 7493
<211> 780
<212> PRT
<213> Homo sapiens

<400> 7493
Met Asp Glu Gln Ala Gly Pro Gly Val Phe Phe Ser Asn Asn His Pro
 1               5                  10                  15      
Gly Ala Gly Gly Ala Lys Gly Leu Gly Pro Leu Ala Glu Ala Ala Ala
            20                  25                  30          
Ala Gly Asp Gly Ala Ala Ala Ala Gly Ala Ala Arg Ala Gln Tyr Ser
        35                  40                  45              
Leu Pro Gly Ile Leu His Phe Leu Gln His Glu Trp Ala Arg Phe Glu
    50                  55                  60                  
Val Glu Arg Ala Gln Trp Glu Val Glu Arg Ala Glu Leu Gln Ala Gln
65                  70                  75                  80  
Ile Ala Phe Leu Gln Gly Glu Arg Lys Gly Gln Glu Asn Leu Lys Lys
                85                  90                  95      
Asp Leu Val Arg Arg Ile Lys Met Leu Glu Tyr Ala Leu Lys Gln Glu
            100                 105                 110         
Arg Ala Lys Tyr His Lys Leu Lys Tyr Gly Thr Glu Leu Asn Gln Gly
        115                 120                 125             
Asp Met Lys Pro Pro Ser Tyr Asp Ser Asp Glu Gly Asn Glu Thr Glu
    130                 135                 140                 
Val Gln Pro Gln Gln Asn Ser Gln Leu Met Trp Lys Gln Gly Arg Gln
145                 150                 155                 160 
Leu Leu Arg Gln Tyr Leu Gln Glu Val Gly Tyr Thr Asp Thr Ile Leu
                165                 170                 175     
Asp Val Lys Ser Lys Arg Val Arg Ala Leu Leu Gly Phe Ser Ile Asp
            180                 185                 190         
Val Thr Asp Arg Glu Asp Asp Lys Asn Gln Asp Ser Val Val Asn Gly
        195                 200                 205             
Thr Glu Ala Glu Val Lys Glu Thr Ala Met Ile Ala Lys Ser Glu Leu
    210                 215                 220                 
Thr Asp Ser Ala Ser Val Leu Asp Asn Phe Lys Phe Leu Glu Ser Ala
225                 230                 235                 240 
Ala Ala Asp Phe Ser Asp Glu Asp Glu Asp Asp Asp Val Asp Gly Arg
                245                 250                 255     
Glu Lys Ser Val Ile Asp Thr Ser Thr Ile Val Arg Lys Lys Ala Leu
            260                 265                 270         
Pro Asp Ser Gly Glu Asp Arg Asp Thr Lys Glu Ala Leu Lys Glu Phe
        275                 280                 285             
Asp Phe Leu Val Thr Ser Glu Glu Gly Asp Asn Glu Ser Arg Ser Ala
    290                 295                 300                 
Gly Asp Gly Thr Asp Trp Glu Lys Glu Asp Gln Cys Leu Met Pro Glu
305                 310                 315                 320 
Ala Trp Asn Val Asp Gln Gly Val Ile Thr Lys Leu Lys Glu Gln Tyr
                325                 330                 335     
Lys Lys Glu Arg Lys Gly Lys Lys Gly Val Lys Arg Pro Asn Arg Ser
            340                 345                 350         
Lys Leu Gln Asp Met Leu Ala Asn Leu Arg Asp Val Asp Glu Leu Pro
        355                 360                 365             
Ser Leu Gln Pro Ser Val Gly Ser Pro Ser Arg Pro Ser Ser Ser Arg
    370                 375                 380                 
Leu Pro Glu His Glu Ile Asn Arg Ala Asp Glu Val Glu Ala Leu Thr
385                 390                 395                 400 
Phe Pro Pro Ser Ser Gly Lys Ser Phe Ile Met Gly Ala Asp Glu Ala
                405                 410                 415     
Leu Glu Ser Glu Leu Gly Pro Gly Glu Leu Ala Gly Leu Thr Val Ala
            420                 425                 430         
Asn Glu Ala Asp Ser Leu Thr Tyr Asp Ile Ala Asn Asn Lys Asp Ala
        435                 440                 445             
Leu Arg Lys Thr Trp Asn Pro Lys Phe Thr Leu Arg Ser His Phe Asp
    450                 455                 460                 
Gly Ile Arg Ala Leu Ala Phe His Pro Ile Glu Pro Val Leu Ile Thr
465                 470                 475                 480 
Ala Ser Glu Asp His Thr Leu Lys Met Trp Asn Leu Gln Lys Thr Ala
                485                 490                 495     
Pro Ala Lys Lys Ser Thr Ser Leu Asp Val Glu Pro Ile Tyr Thr Phe
            500                 505                 510         
Arg Ala His Lys Gly Pro Val Leu Cys Val Val Met Ser Ser Asn Gly
        515                 520                 525             
Glu Gln Cys Tyr Ser Gly Gly Thr Asp Gly Leu Ile Gln Gly Trp Asn
    530                 535                 540                 
Thr Thr Asn Pro Asn Ile Asp Pro Tyr Asp Ser Tyr Asp Pro Ser Val
545                 550                 555                 560 
Leu Arg Gly Pro Leu Leu Gly His Thr Asp Ala Val Trp Gly Leu Ala
                565                 570                 575     
Tyr Ser Ala Ala His Gln Arg Leu Leu Ser Cys Ser Ala Asp Gly Thr
            580                 585                 590         
Leu Arg Leu Trp Asn Thr Thr Glu Val Ala Pro Ala Leu Ser Val Phe
        595                 600                 605             
Asn Asp Ile Lys Glu Leu Gly Ile Pro Ala Ser Val Asp Leu Val Ser
    610                 615                 620                 
Ser Asp Pro Ser His Met Val Ala Ser Phe Ser Lys Gly Tyr Thr Ser
625                 630                 635                 640 
Ile Phe Asn Met Glu Thr Gln Gln Arg Ile Leu Thr Leu Glu Ser Asn
                645                 650                 655     
Val Asp Thr Thr Ala Asn Ser Ser Cys Gln Ile Asn Arg Val Ile Ser
            660                 665                 670         
His Pro Thr Leu Ser Ile Ser Ile Thr Ala His Glu Asp Arg His Ile
        675                 680                 685             
Lys Phe Tyr Asp Asn Asn Thr Gly Lys Leu Ile His Ser Met Val Ala
    690                 695                 700                 
His Leu Glu Ala Val Thr Ser Leu Ala Val Asp Pro Asn Gly Leu Tyr
705                 710                 715                 720 
Leu Met Ser Gly Ser His Asp Cys Ser Ile Arg Leu Trp Asn Leu Glu
                725                 730                 735     
Ser Lys Thr Cys Ile Gln Glu Phe Thr Ala His Arg Lys Lys Phe Glu
            740                 745                 750         
Glu Ser Ile His Asp Val Ala Phe His Pro Ser Lys Cys Tyr Ile Ala
        755                 760                 765             
Ser Ala Gly Ala Asp Ala Leu Ala Lys Val Phe Val
    770                 775                 780 


<210> 7494
<211> 851
<212> PRT
<213> Homo sapiens

<400> 7494
Met Ala Val Glu Thr Leu Ser Pro Asp Trp Glu Phe Asp Arg Val Asp
 1               5                  10                  15      
Asp Gly Ser Gln Lys Ile His Ala Glu Val Gln Leu Lys Asn Tyr Gly
            20                  25                  30          
Lys Phe Leu Glu Glu Tyr Thr Ser Gln Leu Arg Arg Ile Glu Asp Ala
        35                  40                  45              
Leu Asp Asp Ser Ile Gly Asp Val Trp Asp Phe Asn Leu Asp Pro Ile
    50                  55                  60                  
Ala Leu Lys Leu Leu Pro Tyr Glu Gln Ser Ser Leu Leu Glu Leu Ile
65                  70                  75                  80  
Lys Thr Glu Asn Lys Val Leu Asn Lys Val Ile Thr Val Tyr Ala Ala
                85                  90                  95      
Leu Cys Cys Glu Ile Lys Lys Leu Lys Tyr Glu Ala Glu Thr Lys Phe
            100                 105                 110         
Tyr Asn Gly Leu Leu Phe Tyr Gly Glu Gly Ala Thr Asp Ala Ser Met
        115                 120                 125             
Val Glu Gly Asp Cys Gln Ile Gln Met Gly Arg Phe Ile Ser Phe Leu
    130                 135                 140                 
Gln Glu Leu Ser Cys Phe Val Thr Arg Cys Tyr Glu Val Val Met Asn
145                 150                 155                 160 
Val Val His Gln Leu Ala Ala Leu Tyr Ile Ser Asn Lys Ile Ala Pro
                165                 170                 175     
Lys Ile Ile Glu Thr Thr Gly Val His Phe Gln Thr Met Tyr Glu His
            180                 185                 190         
Leu Gly Glu Leu Leu Thr Val Leu Leu Thr Leu Asp Glu Ile Ile Asp
        195                 200                 205             
Asn His Ile Thr Leu Lys Asp His Trp Thr Met Tyr Lys Arg Leu Leu
    210                 215                 220                 
Lys Ser Val His His Asn Pro Ser Lys Phe Gly Ile Gln Glu Glu Lys
225                 230                 235                 240 
Leu Lys Pro Phe Glu Lys Phe Leu Leu Lys Leu Glu Gly Gln Leu Leu
                245                 250                 255     
Asp Gly Met Ile Phe Gln Ala Cys Ile Glu Gln Gln Phe Asp Ser Leu
            260                 265                 270         
Asn Gly Gly Val Ser Val Ser Lys Asn Ser Thr Phe Ala Glu Glu Phe
        275                 280                 285             
Ala His Ser Ile Gln Ser Ile Phe Ala Asn Val Glu Ala Lys Leu Gly
    290                 295                 300                 
Glu Pro Ser Glu Ile Asp Gln Arg Asp Lys Tyr Val Gly Ile Cys Gly
305                 310                 315                 320 
Leu Phe Val Leu His Phe Gln Ile Phe Arg Thr Ile Asp Lys Lys Phe
                325                 330                 335     
Tyr Lys Ser Leu Leu Asp Ile Cys Lys Lys Val Pro Ala Ile Thr Leu
            340                 345                 350         
Thr Ala Asn Ile Ile Trp Phe Pro Asp Asn Phe Leu Ile Gln Lys Ile
        355                 360                 365             
Pro Ala Ala Ala Lys Leu Leu Asp Arg Lys Ser Leu Gln Ala Ile Lys
    370                 375                 380                 
Ile His Arg Asp Thr Phe Leu Gln Gln Lys Ala Gln Ser Leu Thr Lys
385                 390                 395                 400 
Asp Val Gln Ser Tyr Tyr Val Phe Val Ser Ser Trp Met Met Lys Met
                405                 410                 415     
Glu Ser Ile Leu Ser Lys Glu Gln Arg Met Asp Lys Phe Ala Glu Asp
            420                 425                 430         
Leu Thr Asn Arg Cys Asn Val Phe Ile Gln Gly Phe Leu Tyr Ala Tyr
        435                 440                 445             
Ser Ile Ser Thr Ile Ile Lys Thr Thr Met Asn Leu Tyr Met Ser Met
    450                 455                 460                 
Gln Lys Pro Met Thr Lys Thr Ser Val Lys Ala Leu Cys Arg Leu Val
465                 470                 475                 480 
Glu Leu Leu Lys Ala Ile Glu His Met Phe Tyr Arg Arg Ser Met Val
                485                 490                 495     
Val Ala Asp Ser Val Ser His Ile Thr Gln His Leu Gln His Gln Ala
            500                 505                 510         
Leu His Ser Ile Ser Val Ala Lys Lys Arg Val Ile Ser Asp Lys Lys
        515                 520                 525             
Tyr Ser Glu Gln Arg Leu Asp Val Leu Ser Ala Leu Val Leu Ala Glu
    530                 535                 540                 
Asn Thr Leu Asn Gly Pro Ser Thr Lys Gln Arg Arg Leu Ile Val Ser
545                 550                 555                 560 
Leu Ala Leu Ser Val Gly Thr Gln Met Lys Thr Phe Lys Asp Glu Glu
                565                 570                 575     
Leu Phe Pro Leu Gln Val Val Met Lys Lys Leu Asp Leu Ile Ser Glu
            580                 585                 590         
Leu Arg Glu Arg Val Gln Thr Gln Cys Asp Cys Cys Phe Leu Tyr Arg
        595                 600                 605             
His Arg Ala Val Phe Pro Ile Tyr Leu Asp Asp Val Tyr Glu Asn Ala
    610                 615                 620                 
Val Asp Ala Ala Arg Leu His Tyr Met Phe Ser Ala Leu Arg Asp Cys
625                 630                 635                 640 
Val Pro Ala Met Met His Ala Arg His Leu Glu Ser Tyr Glu Ile Leu
                645                 650                 655     
Leu Asp Cys Tyr Asp Lys Glu Ile Met Glu Ile Leu Asn Glu His Leu
            660                 665                 670         
Leu Asp Lys Leu Cys Lys Glu Ile Glu Lys Asp Leu Arg Leu Ser Val
        675                 680                 685             
His Thr His Leu Lys Leu Asp Asp Arg Asn Pro Phe Lys Val Gly Met
    690                 695                 700                 
Lys Asp Leu Ala Leu Phe Phe Ser Leu Asn Pro Ile Arg Phe Phe Asn
705                 710                 715                 720 
Arg Phe Ile Asp Ile Arg Ala Tyr Val Thr His Tyr Leu Asp Lys Thr
                725                 730                 735     
Phe Tyr Asn Leu Thr Thr Val Ala Leu His Asp Trp Ala Thr Tyr Ser
            740                 745                 750         
Glu Met Arg Asn Leu Ala Ala Gln Arg Tyr Gly Leu Val Met Thr Glu
        755                 760                 765             
Ala His Leu Pro Ser Gln Thr Leu Glu Gln Gly Leu Asp Val Leu Glu
    770                 775                 780                 
Ile Met Arg Asn Ile His Ile Phe Val Ser Arg Tyr Leu Tyr Asn Leu
785                 790                 795                 800 
Asn Asn Gln Ile Phe Ile Glu Arg Thr Ser Asn Asn Lys His Leu Asn
                805                 810                 815     
Thr Ile Asn Ile Arg His Ile Ala Asn Ser Ile Arg Thr His Gly Thr
            820                 825                 830         
Gly Ile Met Asn Thr Thr Lys Trp Ala Phe Thr Ala Trp Arg Gly Gly
        835                 840                 845             
Pro Arg Leu
    850     


<210> 7495
<211> 903
<212> PRT
<213> Homo sapiens

<400> 7495
Met Glu Glu Arg Arg Pro His Leu Asp Ala Arg Pro Arg Asn Ser His
 1               5                  10                  15      
Thr Asn His Arg Gly Pro Val Asp Gly Glu Leu Pro Pro Arg Ala Arg
            20                  25                  30          
Asn Gln Ala Asn Asn Pro Pro Ala Asn Ala Leu Arg Gly Gly Ala Ser
        35                  40                  45              
His Pro Gly Arg His Pro Arg Ala Asn Asn His Pro Ala Ala Tyr Trp
    50                  55                  60                  
Gln Arg Glu Glu Arg Phe Arg Ala Met Gly Arg Asn Pro His Gln Gly
65                  70                  75                  80  
Arg Arg Asn Gln Glu Gly His Ala Ser Asp Glu Ala Arg Asp Gln Arg
                85                  90                  95      
His Asp Gln Glu Asn Asp Thr Arg Trp Arg Asn Gly Asn Gln Asp Cys
            100                 105                 110         
Arg Asn Arg Arg Pro Pro Trp Ser Asn Asp Asn Phe Gln Gln Trp Arg
        115                 120                 125             
Thr Pro His Gln Lys Pro Thr Glu Gln Pro Gln Gln Ala Lys Lys Leu
    130                 135                 140                 
Gly Tyr Lys Phe Leu Glu Ser Leu Leu Gln Lys Asp Pro Ser Glu Val
145                 150                 155                 160 
Val Ile Thr Leu Ala Thr Ser Leu Gly Leu Lys Glu Leu Leu Ser His
                165                 170                 175     
Ser Ser Met Lys Ser Asn Phe Leu Glu Leu Ile Cys Gln Val Leu Arg
            180                 185                 190         
Lys Ala Cys Ser Ser Lys Met Asp Arg Gln Ser Val Leu His Val Leu
        195                 200                 205             
Gly Ile Leu Lys Asn Ser Lys Phe Leu Lys Val Cys Leu Pro Ala Tyr
    210                 215                 220                 
Val Val Gly Met Ile Thr Glu Pro Ile Pro Asp Ile Arg Asn Gln Tyr
225                 230                 235                 240 
Pro Glu His Ile Ser Asn Ile Ile Ser Leu Leu Gln Asp Leu Val Ser
                245                 250                 255     
Val Phe Pro Ala Ser Ser Val Gln Glu Thr Ser Met Leu Val Ser Leu
            260                 265                 270         
Leu Pro Thr Ser Leu Asn Ala Leu Arg Ala Ser Gly Val Asp Ile Glu
        275                 280                 285             
Glu Glu Thr Glu Lys Asn Leu Glu Lys Val Gln Thr Ile Ile Glu His
    290                 295                 300                 
Leu Gln Glu Lys Arg Arg Glu Gly Thr Leu Arg Val Asp Thr Tyr Thr
305                 310                 315                 320 
Leu Val Gln Pro Glu Ala Glu Asp His Val Glu Ser Tyr Arg Thr Met
                325                 330                 335     
Pro Ile Tyr Pro Thr Tyr Asn Glu Val His Leu Asp Glu Arg Pro Phe
            340                 345                 350         
Leu Arg Pro Asn Ile Ile Ser Gly Lys Tyr Asp Ser Thr Ala Ile Tyr
        355                 360                 365             
Leu Asp Thr His Phe Arg Leu Leu Arg Glu Asp Phe Val Arg Pro Leu
    370                 375                 380                 
Arg Glu Gly Ile Leu Glu Leu Leu Gln Ser Phe Glu Asp Gln Gly Leu
385                 390                 395                 400 
Arg Lys Arg Lys Phe Asp Asp Ile Arg Ile Tyr Phe Asp Thr Arg Ile
                405                 410                 415     
Ile Thr Pro Met Cys Ser Ser Ser Gly Ile Val Tyr Lys Val Gln Phe
            420                 425                 430         
Asp Thr Lys Pro Leu Lys Phe Val Arg Trp Gln Asn Ser Lys Arg Leu
        435                 440                 445             
Leu Tyr Gly Ser Leu Val Cys Met Ser Lys Asp Asn Phe Glu Thr Phe
    450                 455                 460                 
Leu Phe Ala Thr Val Ser Asn Arg Glu Gln Glu Asp Leu Cys Arg Gly
465                 470                 475                 480 
Ile Val Gln Leu Cys Phe Asn Glu Gln Ser Gln Gln Leu Leu Ala Glu
                485                 490                 495     
Val Gln Pro Ser Asp Ser Phe Leu Met Val Glu Thr Thr Ala Tyr Phe
            500                 505                 510         
Glu Ala Tyr Arg His Val Leu Glu Gly Leu Gln Glu Val Gln Glu Glu
        515                 520                 525             
Asp Val Pro Phe Gln Arg Asn Ile Val Glu Cys Asn Ser His Val Lys
    530                 535                 540                 
Glu Pro Arg Tyr Leu Leu Met Gly Gly Arg Tyr Asp Phe Thr Pro Leu
545                 550                 555                 560 
Ile Glu Asn Pro Ser Ala Thr Gly Glu Phe Leu Arg Asn Val Glu Gly
                565                 570                 575     
Leu Arg His Pro Arg Ile Asn Val Leu Asp Pro Gly Gln Trp Pro Ser
            580                 585                 590         
Lys Glu Ala Leu Lys Leu Asp Asp Ser Gln Met Glu Ala Leu Gln Phe
        595                 600                 605             
Ala Leu Thr Arg Glu Leu Ala Ile Ile Gln Gly Pro Pro Gly Thr Gly
    610                 615                 620                 
Lys Thr Tyr Val Gly Leu Lys Ile Val Gln Ala Leu Leu Thr Asn Glu
625                 630                 635                 640 
Ser Val Trp Gln Ile Ser Leu Gln Lys Phe Pro Ile Leu Val Val Cys
                645                 650                 655     
Tyr Thr Asn His Ala Leu Asp Gln Phe Leu Glu Gly Ile Tyr Asn Cys
            660                 665                 670         
Gln Lys Thr Ser Ile Val Arg Val Gly Gly Arg Ser Asn Ser Glu Ile
        675                 680                 685             
Leu Lys Gln Phe Thr Leu Arg Glu Leu Arg Asn Lys Arg Glu Phe Arg
    690                 695                 700                 
Arg Asn Leu Pro Met His Leu Arg Arg Ala Tyr Met Ser Ile Met Thr
705                 710                 715                 720 
Gln Met Lys Glu Ser Glu Gln Glu Leu His Glu Gly Ala Lys Thr Leu
                725                 730                 735     
Glu Cys Thr Met Arg Gly Val Leu Arg Glu Gln Tyr Leu Gln Lys Tyr
            740                 745                 750         
Ile Ser Pro Gln His Trp Glu Ser Leu Met Asn Gly Pro Val Gln Asp
        755                 760                 765             
Ser Glu Trp Ile Cys Phe Gln His Trp Lys His Ser Met Met Leu Glu
    770                 775                 780                 
Trp Leu Gly Leu Gly Val Gly Ser Phe Thr Gln Ser Val Ser Pro Ala
785                 790                 795                 800 
Gly Pro Glu Asn Thr Ala Gln Ala Glu Gly Asp Glu Glu Glu Glu Gly
                805                 810                 815     
Glu Glu Glu Ser Ser Leu Ile Glu Ile Ala Glu Glu Ala Asp Leu Ile
            820                 825                 830         
Gln Ala Asp Arg Val Ile Glu Glu Glu Glu Val Val Arg Pro Gln Arg
        835                 840                 845             
Arg Lys Lys Glu Glu Ser Gly Ala Asp Gln Glu Leu Ala Lys Met Leu
    850                 855                 860                 
Leu Ala Met Arg Leu Asp His Cys Gly Thr Gly Thr Ala Ala Gly Gln
865                 870                 875                 880 
Glu Gln Ala Thr Gly Glu Trp Gln Thr Val Pro Cys Leu Val Leu Met
                885                 890                 895     
Ser Ala Asp Pro Ala Gln Pro
            900             


<210> 7496
<211> 1918
<212> PRT
<213> Homo sapiens

<400> 7496
Met Glu Glu Arg Arg Pro His Leu Asp Ala Arg Pro Arg Asn Ser His
 1               5                  10                  15      
Thr Asn His Arg Gly Pro Val Asp Gly Glu Leu Pro Pro Arg Ala Arg
            20                  25                  30          
Asn Gln Ala Asn Asn Pro Pro Ala Asn Ala Leu Arg Gly Gly Ala Ser
        35                  40                  45              
His Pro Gly Arg His Pro Arg Ala Asn Asn His Pro Ala Ala Tyr Trp
    50                  55                  60                  
Gln Arg Glu Glu Arg Phe Arg Ala Met Gly Arg Asn Pro His Gln Gly
65                  70                  75                  80  
Arg Arg Asn Gln Glu Gly His Ala Ser Asp Glu Ala Arg Asp Gln Arg
                85                  90                  95      
His Asp Gln Glu Asn Asp Thr Arg Trp Arg Asn Gly Asn Gln Asp Cys
            100                 105                 110         
Arg Asn Arg Arg Pro Pro Trp Ser Asn Asp Asn Phe Gln Gln Trp Arg
        115                 120                 125             
Thr Pro His Gln Lys Pro Thr Glu Gln Pro Gln Gln Ala Lys Lys Leu
    130                 135                 140                 
Gly Tyr Lys Phe Leu Glu Ser Leu Leu Gln Lys Asp Pro Ser Glu Val
145                 150                 155                 160 
Val Ile Thr Leu Ala Thr Ser Leu Gly Leu Lys Glu Leu Leu Ser His
                165                 170                 175     
Ser Ser Met Lys Ser Asn Phe Leu Glu Leu Ile Cys Gln Val Leu Arg
            180                 185                 190         
Lys Ala Cys Ser Ser Lys Met Asp Arg Gln Ser Val Leu His Val Leu
        195                 200                 205             
Gly Ile Leu Lys Asn Ser Lys Phe Leu Lys Val Cys Leu Pro Ala Tyr
    210                 215                 220                 
Val Val Gly Met Ile Thr Glu Pro Ile Pro Asp Ile Arg Asn Gln Tyr
225                 230                 235                 240 
Pro Glu His Ile Ser Asn Ile Ile Ser Leu Leu Gln Asp Leu Val Ser
                245                 250                 255     
Val Phe Pro Ala Ser Ser Val Gln Glu Thr Ser Met Leu Val Ser Leu
            260                 265                 270         
Leu Pro Thr Ser Leu Asn Ala Leu Arg Ala Ser Gly Val Asp Ile Glu
        275                 280                 285             
Glu Glu Thr Glu Lys Asn Leu Glu Lys Val Gln Thr Ile Ile Glu His
    290                 295                 300                 
Leu Gln Glu Lys Arg Arg Glu Gly Thr Leu Arg Val Asp Thr Tyr Thr
305                 310                 315                 320 
Leu Val Gln Pro Glu Ala Glu Asp His Val Glu Ser Tyr Arg Thr Met
                325                 330                 335     
Pro Ile Tyr Pro Thr Tyr Asn Glu Val His Leu Asp Glu Arg Pro Phe
            340                 345                 350         
Leu Arg Pro Asn Ile Ile Ser Gly Lys Tyr Asp Ser Thr Ala Ile Tyr
        355                 360                 365             
Leu Asp Thr His Phe Arg Leu Leu Arg Glu Asp Phe Val Arg Pro Leu
    370                 375                 380                 
Arg Glu Gly Ile Leu Glu Leu Leu Gln Ser Phe Glu Asp Gln Gly Leu
385                 390                 395                 400 
Arg Lys Arg Lys Phe Asp Asp Ile Arg Ile Tyr Phe Asp Thr Arg Ile
                405                 410                 415     
Ile Thr Pro Met Cys Ser Ser Ser Gly Ile Val Tyr Lys Val Gln Phe
            420                 425                 430         
Asp Thr Lys Pro Leu Lys Phe Val Arg Trp Gln Asn Ser Lys Arg Leu
        435                 440                 445             
Leu Tyr Gly Ser Leu Val Cys Met Ser Lys Asp Asn Phe Glu Thr Phe
    450                 455                 460                 
Leu Phe Ala Thr Val Ser Asn Arg Glu Gln Glu Asp Leu Cys Arg Gly
465                 470                 475                 480 
Ile Val Gln Leu Cys Phe Asn Glu Gln Ser Gln Gln Leu Leu Ala Glu
                485                 490                 495     
Val Gln Pro Ser Asp Ser Phe Leu Met Val Glu Thr Thr Ala Tyr Phe
            500                 505                 510         
Glu Ala Tyr Arg His Val Leu Glu Gly Leu Gln Glu Val Gln Glu Glu
        515                 520                 525             
Asp Val Pro Phe Gln Arg Asn Ile Val Glu Cys Asn Ser His Val Lys
    530                 535                 540                 
Glu Pro Arg Tyr Leu Leu Met Gly Gly Arg Tyr Asp Phe Thr Pro Leu
545                 550                 555                 560 
Ile Glu Asn Pro Ser Ala Thr Gly Glu Phe Leu Arg Asn Val Glu Gly
                565                 570                 575     
Leu Arg His Pro Arg Ile Asn Val Leu Asp Pro Gly Gln Trp Pro Ser
            580                 585                 590         
Lys Glu Ala Leu Lys Leu Asp Asp Ser Gln Met Glu Ala Leu Gln Phe
        595                 600                 605             
Ala Leu Thr Arg Glu Leu Ala Ile Ile Gln Gly Pro Pro Gly Thr Gly
    610                 615                 620                 
Lys Thr Tyr Val Gly Leu Lys Ile Val Gln Ala Leu Leu Thr Asn Glu
625                 630                 635                 640 
Ser Val Trp Gln Ile Ser Leu Gln Lys Phe Pro Ile Leu Val Val Cys
                645                 650                 655     
Tyr Thr Asn His Ala Leu Asp Gln Phe Leu Glu Gly Ile Tyr Asn Cys
            660                 665                 670         
Gln Lys Thr Ser Ile Val Arg Val Gly Gly Arg Ser Asn Ser Glu Ile
        675                 680                 685             
Leu Lys Gln Phe Thr Leu Arg Glu Leu Arg Asn Lys Arg Glu Phe Arg
    690                 695                 700                 
Arg Asn Leu Pro Met His Leu Arg Arg Ala Tyr Met Ser Ile Met Thr
705                 710                 715                 720 
Gln Met Lys Glu Ser Glu Gln Glu Leu His Glu Gly Ala Lys Thr Leu
                725                 730                 735     
Glu Cys Thr Met Arg Gly Val Leu Arg Glu Gln Tyr Leu Gln Lys Tyr
            740                 745                 750         
Ile Ser Pro Gln His Trp Glu Ser Leu Met Asn Gly Pro Val Gln Asp
        755                 760                 765             
Ser Glu Trp Ile Cys Phe Gln His Trp Lys His Ser Met Met Leu Glu
    770                 775                 780                 
Trp Leu Gly Leu Gly Val Gly Ser Phe Thr Gln Ser Val Ser Pro Ala
785                 790                 795                 800 
Gly Pro Glu Asn Thr Ala Gln Ala Glu Gly Asp Glu Glu Glu Glu Gly
                805                 810                 815     
Glu Glu Glu Ser Ser Leu Ile Glu Ile Ala Glu Glu Ala Asp Leu Ile
            820                 825                 830         
Gln Ala Asp Arg Val Ile Glu Glu Glu Glu Val Val Arg Pro Gln Arg
        835                 840                 845             
Arg Lys Lys Glu Glu Ser Gly Ala Asp Gln Glu Leu Ala Lys Met Leu
    850                 855                 860                 
Leu Ala Met Arg Leu Asp His Cys Gly Thr Gly Thr Ala Ala Gly Gln
865                 870                 875                 880 
Glu Gln Ala Thr Gly Glu Trp Gln Thr Gln Arg Asn Gln Lys Lys Lys
                885                 890                 895     
Met Lys Lys Arg Val Lys Asp Glu Leu Arg Lys Leu Asn Thr Met Thr
            900                 905                 910         
Ala Ala Glu Ala Asn Glu Ile Glu Asp Val Trp Gln Leu Asp Leu Ser
        915                 920                 925             
Ser Arg Trp Gln Leu Tyr Arg Leu Trp Leu Gln Leu Tyr Gln Ala Asp
    930                 935                 940                 
Thr Arg Arg Lys Ile Leu Ser Tyr Glu Arg Gln Tyr Arg Thr Ser Ala
945                 950                 955                 960 
Glu Arg Met Ala Glu Leu Arg Leu Gln Glu Asp Leu His Ile Leu Lys
                965                 970                 975     
Asp Ala Gln Val Val Gly Met Thr Thr Thr Gly Ala Ala Lys Tyr Arg
            980                 985                 990         
Gln Ile Leu Gln Lys Val Glu Pro Arg Ile Val Ile Val Glu Glu Ala
        995                 1000                1005            
Ala Glu Val Leu Glu Ala His Thr Ile Ala Thr Leu Ser Lys Ala Cys
    1010                1015                1020                
Gln His Leu Ile Leu Ile Gly Asp His Gln Gln Leu Arg Pro Ser Ala
1025                1030                1035                1040
Asn Val Tyr Asp Leu Ala Lys Asn Phe Asn Leu Glu Val Ser Leu Phe
                1045                1050                1055    
Glu Arg Leu Val Lys Val Asn Ile Pro Phe Val Arg Leu Asn Tyr Gln
            1060                1065                1070        
His Arg Met Cys Pro Glu Ile Ala Arg Leu Leu Thr Pro His Ile Tyr
        1075                1080                1085            
Gln Asp Leu Glu Asn His Pro Ser Val Leu Lys Tyr Glu Lys Ile Lys
    1090                1095                1100                
Gly Val Ser Ser Asn Leu Phe Phe Val Glu His Asn Phe Pro Glu Gln
1105                1110                1115                1120
Glu Ile Gln Glu Gly Lys Ser His Gln Asn Gln His Glu Ala His Phe
                1125                1130                1135    
Val Val Glu Leu Cys Lys Tyr Phe Leu Cys Gln Glu Tyr Leu Pro Ser
            1140                1145                1150        
Gln Ile Thr Ile Leu Thr Thr Tyr Thr Gly Gln Leu Phe Cys Leu Arg
        1155                1160                1165            
Lys Leu Met Pro Ala Lys Thr Phe Ala Gly Val Arg Val His Val Val
    1170                1175                1180                
Asp Lys Tyr Gln Gly Glu Glu Asn Asp Ile Ile Leu Leu Ser Leu Val
1185                1190                1195                1200
Arg Ser Asn Gln Glu Gly Lys Val Gly Phe Leu Gln Ile Ser Asn Arg
                1205                1210                1215    
Ile Cys Val Ala Leu Ser Arg Ala Lys Lys Gly Met Tyr Cys Ile Gly
            1220                1225                1230        
Asn Met Gln Met Leu Ala Lys Val Pro Leu Trp Ser Lys Ile Ile His
        1235                1240                1245            
Thr Leu Arg Glu Asn Asn Gln Ile Gly Pro Met Leu Arg Leu Cys Cys
    1250                1255                1260                
Gln Asn His Pro Glu Thr His Thr Leu Val Ser Lys Ala Ser Asp Phe
1265                1270                1275                1280
Gln Lys Val Pro Glu Gly Gly Cys Ser Leu Pro Cys Glu Phe Arg Leu
                1285                1290                1295    
Gly Cys Gly His Val Cys Thr Arg Ala Cys His Pro Tyr Asp Ser Ser
            1300                1305                1310        
His Lys Glu Phe Gln Cys Met Lys Pro Cys Gln Lys Val Ile Cys Gln
        1315                1320                1325            
Glu Gly His Arg Cys Pro Leu Val Cys Phe Gln Glu Cys Gln Pro Cys
    1330                1335                1340                
Gln Val Lys Val Pro Lys Thr Ile Pro Arg Cys Gly His Glu Gln Met
1345                1350                1355                1360
Val Pro Cys Ser Val Pro Glu Ser Asp Phe Cys Cys Gln Glu Pro Cys
                1365                1370                1375    
Ser Lys Ser Leu Arg Cys Gly His Arg Cys Ser His Pro Cys Gly Glu
            1380                1385                1390        
Asp Cys Val Gln Leu Cys Ser Glu Met Val Thr Ile Lys Leu Lys Cys
        1395                1400                1405            
Gly His Ser Gln Pro Val Lys Cys Gly His Val Glu Gly Leu Leu Tyr
    1410                1415                1420                
Gly Gly Leu Leu Val Lys Cys Thr Thr Lys Cys Gly Thr Ile Leu Asp
1425                1430                1435                1440
Cys Gly His Pro Cys Pro Gly Ser Cys His Ser Cys Phe Glu Gly Arg
                1445                1450                1455    
Phe His Glu Arg Cys Gln Gln Pro Cys Lys Arg Leu Leu Ile Cys Ser
            1460                1465                1470        
His Lys Cys Gln Glu Pro Cys Ile Gly Glu Cys Pro Pro Cys Gln Arg
        1475                1480                1485            
Thr Cys Gln Asn Arg Cys Val His Ser Gln Cys Lys Lys Lys Cys Gly
    1490                1495                1500                
Glu Leu Cys Ser Pro Cys Val Glu Pro Cys Val Trp Arg Cys Gln His
1505                1510                1515                1520
Tyr Gln Cys Thr Lys Leu Cys Ser Glu Pro Cys Asn Arg Pro Pro Cys
                1525                1530                1535    
Tyr Val Pro Cys Thr Lys Leu Leu Val Cys Gly His Pro Cys Ile Gly
            1540                1545                1550        
Leu Cys Gly Glu Pro Cys Pro Lys Lys Cys Arg Ile Cys His Met Asp
        1555                1560                1565            
Glu Val Thr Gln Ile Phe Phe Gly Phe Glu Asp Glu Pro Asp Ala Arg
    1570                1575                1580                
Phe Val Gln Leu Glu Asp Cys Ser His Ile Phe Glu Val Gln Ala Leu
1585                1590                1595                1600
Asp Arg Tyr Met Asn Glu Gln Lys Asp Asp Glu Val Ala Ile Arg Leu
                1605                1610                1615    
Lys Val Cys Pro Ile Cys Gln Val Pro Ile Arg Lys Asn Leu Arg Tyr
            1620                1625                1630        
Gly Thr Ser Ile Lys Gln Arg Leu Glu Glu Ile Glu Ile Ile Lys Glu
        1635                1640                1645            
Lys Ile Gln Gly Ser Ala Gly Glu Ile Ala Thr Ser Gln Glu Arg Leu
    1650                1655                1660                
Lys Ala Leu Leu Glu Arg Lys Ser Leu Leu His Gln Leu Leu Pro Glu
1665                1670                1675                1680
Asp Phe Leu Met Leu Lys Glu Lys Leu Ala Gln Lys Asn Leu Ser Val
                1685                1690                1695    
Lys Asp Leu Gly Leu Val Glu Asn Tyr Ile Ser Phe Tyr Asp His Leu
            1700                1705                1710        
Ala Ser Leu Trp Asp Ser Leu Lys Lys Met His Val Leu Glu Glu Lys
        1715                1720                1725            
Arg Val Arg Thr Arg Leu Glu Gln Val His Glu Trp Leu Ala Lys Lys
    1730                1735                1740                
Arg Leu Ser Phe Thr Ser Gln Glu Leu Ser Asp Leu Arg Ser Glu Ile
1745                1750                1755                1760
Gln Arg Leu Thr Tyr Leu Val Asn Leu Leu Thr Arg Tyr Lys Ile Ala
                1765                1770                1775    
Glu Lys Lys Val Lys Asp Ser Ile Ala Val Glu Val Tyr Ser Val Gln
            1780                1785                1790        
Asn Ile Leu Glu Lys Thr Cys Lys Phe Thr Gln Glu Asp Glu Gln Leu
        1795                1800                1805            
Val Gln Glu Lys Met Glu Ala Leu Lys Ala Thr Leu Pro Cys Ser Gly
    1810                1815                1820                
Leu Gly Ile Ser Glu Glu Glu Arg Val Gln Ile Val Ser Ala Ile Gly
1825                1830                1835                1840
Tyr Pro Arg Gly His Trp Phe Lys Cys Arg Asn Gly His Ile Tyr Val
                1845                1850                1855    
Ile Gly Asp Cys Gly Gly Ala Met Glu Arg Gly Thr Cys Pro Asp Cys
            1860                1865                1870        
Lys Glu Val Ile Gly Gly Thr Asn His Thr Leu Glu Arg Ser Asn Gln
        1875                1880                1885            
Leu Ala Ser Glu Met Asp Gly Ala Gln His Ala Ala Trp Ser Asp Thr
    1890                1895                1900                
Ala Asn Asn Leu Met Asn Phe Glu Glu Ile Gln Gly Met Met
1905                1910                1915            


<210> 7497
<211> 611
<212> PRT
<213> Homo sapiens

<400> 7497
Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys
 1               5                  10                  15      
Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Ile Gly
            20                  25                  30          
Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Gln
        35                  40                  45              
Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile
    50                  55                  60                  
Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys
65                  70                  75                  80  
Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro
                85                  90                  95      
Pro Ser Lys Thr Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu
            100                 105                 110         
Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln
        115                 120                 125             
Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser
    130                 135                 140                 
Glu Asn Val Pro Ser Pro Thr His Pro Pro Val Val Ile Asn Ala Ala
145                 150                 155                 160 
Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu
                165                 170                 175     
Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu
            180                 185                 190         
Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu
        195                 200                 205             
Cys Leu Asn Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys
    210                 215                 220                 
Met Lys Glu Lys Ser Lys Lys Gln Gly Glu Gly Ser Ser Gly Val Ser
225                 230                 235                 240 
Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn
                245                 250                 255     
Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu
            260                 265                 270         
Glu Pro Leu Val Arg Leu Ser Leu Thr Glu Arg Leu Gly Lys Arg Lys
        275                 280                 285             
Phe Ser Ala Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala
    290                 295                 300                 
Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Ile Asp Lys
305                 310                 315                 320 
Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly
                325                 330                 335     
Met Ser Ala Asp Pro Asp Asn Glu Asp Ala Thr Asp Lys Val Asn Lys
            340                 345                 350         
Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Ile Leu Leu Glu Arg
        355                 360                 365             
Ala Ser Gln Lys Arg Gly Glu Leu Gln Thr Lys Leu Lys Thr Glu Gly
    370                 375                 380                 
Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr
385                 390                 395                 400 
Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Lys Lys His Arg
                405                 410                 415     
Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile
            420                 425                 430         
Lys Leu Lys Ile Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro
        435                 440                 445             
Ile Val Ala Ser Arg Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys
    450                 455                 460                 
Ser Met Gln Glu Val His Ile Lys Thr Leu Glu Glu Ile Lys Leu Glu
465                 470                 475                 480 
Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro
                485                 490                 495     
Ser Gln His Glu Ala Thr Pro Gly Ala Arg Arg Leu Leu Arg Ile Thr
            500                 505                 510         
Lys Arg Thr Gly Met Lys Glu Glu Lys Asn Leu Gln Glu Gly Asn Glu
        515                 520                 525             
Val Asp Ser Gln Ser Ser Ile Arg Thr Glu Ala Lys Glu Ala Ser Gly
    530                 535                 540                 
Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu
545                 550                 555                 560 
Thr Met Arg Glu Lys His Met Gln Lys Gln Pro Gly Asn Gly Lys Lys
                565                 570                 575     
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
            580                 585                 590         
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
        595                 600                 605             
Lys Lys Lys
    610     


<210> 7498
<211> 818
<212> PRT
<213> Homo sapiens

<400> 7498
Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys
 1               5                  10                  15      
Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Ile Gly
            20                  25                  30          
Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Gln
        35                  40                  45              
Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile
    50                  55                  60                  
Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys
65                  70                  75                  80  
Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro
                85                  90                  95      
Pro Ser Lys Thr Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu
            100                 105                 110         
Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln
        115                 120                 125             
Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser
    130                 135                 140                 
Glu Asn Val Pro Ser Pro Thr His Pro Pro Val Val Ile Asn Ala Ala
145                 150                 155                 160 
Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu
                165                 170                 175     
Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu
            180                 185                 190         
Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu
        195                 200                 205             
Cys Leu Asn Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys
    210                 215                 220                 
Met Lys Glu Lys Ser Lys Lys Gln Gly Glu Gly Ser Ser Gly Val Ser
225                 230                 235                 240 
Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn
                245                 250                 255     
Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu
            260                 265                 270         
Glu Pro Leu Val Arg Leu Ser Leu Thr Glu Arg Leu Gly Lys Arg Lys
        275                 280                 285             
Phe Ser Ala Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala
    290                 295                 300                 
Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Ile Asp Lys
305                 310                 315                 320 
Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly
                325                 330                 335     
Met Ser Ala Asp Pro Asp Asn Glu Asp Ala Thr Asp Lys Val Asn Lys
            340                 345                 350         
Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Ile Leu Leu Glu Arg
        355                 360                 365             
Ala Ser Gln Lys Arg Gly Glu Leu Gln Thr Lys Leu Lys Thr Glu Gly
    370                 375                 380                 
Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr
385                 390                 395                 400 
Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Lys Lys His Arg
                405                 410                 415     
Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile
            420                 425                 430         
Lys Leu Lys Ile Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro
        435                 440                 445             
Ile Val Ala Ser Arg Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys
    450                 455                 460                 
Ser Met Gln Glu Val His Ile Lys Thr Leu Glu Glu Ile Lys Leu Glu
465                 470                 475                 480 
Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro
                485                 490                 495     
Ser Gln His Glu Ala Thr Pro Gly Ala Arg Arg Leu Leu Arg Ile Thr
            500                 505                 510         
Lys Arg Thr Gly Met Lys Glu Glu Lys Asn Leu Gln Glu Gly Asn Glu
        515                 520                 525             
Val Asp Ser Gln Ser Ser Ile Arg Thr Glu Ala Lys Glu Ala Ser Gly
    530                 535                 540                 
Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu
545                 550                 555                 560 
Thr Met Arg Glu Lys His Met Gln Lys Gln Gln Glu Arg Glu Lys Ser
                565                 570                 575     
Val Leu Thr Pro Leu Arg Gly Asp Val Ala Ser Cys Asn Thr Gln Val
            580                 585                 590         
Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Arg His Leu
        595                 600                 605             
Thr Lys Arg Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr
    610                 615                 620                 
Ser Gly Ile Gly Asp Ser Leu Leu Asn Val Lys Cys Ala Ala Gln Thr
625                 630                 635                 640 
Leu Glu Lys Arg Gly Lys Gly Lys Tyr Phe Leu Pro Phe Val Ala Lys
                645                 650                 655     
Pro Lys Val Asn Val Lys Pro Ser Val Val Lys Val Val Ser Ser Pro
            660                 665                 670         
Lys Leu Ala Pro Lys Arg Lys Ala Val Glu Met His Ala Ala Val Ile
        675                 680                 685             
Ala Ala Val Lys Pro Leu Ser Ser Ser Ser Val Leu Gln Glu Pro Pro
    690                 695                 700                 
Ala Lys Lys Ala Ala Val Ala Val Val Pro Leu Val Ser Glu Asp Lys
705                 710                 715                 720 
Ser Val Thr Val Pro Glu Ala Glu Asn Pro Arg Asp Ser Leu Val Leu
                725                 730                 735     
Pro Pro Thr Gln Ser Ser Ser Asp Ser Ser Pro Pro Glu Val Ser Gly
            740                 745                 750         
Pro Ser Ser Ser Gln Met Ser Met Lys Thr Arg Arg Leu Ser Ser Ala
        755                 760                 765             
Ser Thr Gly Lys Pro Pro Leu Ser Val Glu Asp Asp Phe Glu Lys Leu
    770                 775                 780                 
Ile Trp Glu Ile Ser Gly Gly Lys Leu Glu Ala Glu Ile Asp Leu Asp
785                 790                 795                 800 
Pro Gly Lys Asp Glu Asp Asp Leu Leu Leu Glu Leu Ser Glu Met Ile
                805                 810                 815     
Asp Ser
        


<210> 7499
<211> 180
<212> PRT
<213> Homo sapiens

<400> 7499
Met Glu Ile Ala Pro Gln Glu Ala Pro Pro Val Pro Gly Ala Asp Gly
 1               5                  10                  15      
Asp Ile Glu Glu Ala Pro Ala Glu Ala Gly Ser Pro Ser Pro Ala Ser
            20                  25                  30          
Pro Pro Ala Asp Gly Arg Leu Lys Ala Ala Ala Lys Arg Val Thr Phe
        35                  40                  45              
Pro Ser Asp Glu Asp Ile Val Ser Gly Ala Val Glu Pro Lys Asp Pro
    50                  55                  60                  
Trp Arg His Ala Gln Asn Val Thr Val Asp Glu Val Ile Gly Ala Tyr
65                  70                  75                  80  
Lys Gln Ala Cys Gln Lys Leu Asn Cys Arg Gln Ile Pro Lys Leu Leu
                85                  90                  95      
Arg Gln Leu Gln Glu Phe Thr Asp Leu Gly His Arg Leu Asp Cys Leu
            100                 105                 110         
Asp Leu Lys Gly Glu Lys Leu Asp Tyr Lys Thr Cys Glu Ala Leu Glu
        115                 120                 125             
Glu Val Phe Lys Arg Leu Gln Phe Lys Val Val Asp Leu Glu Gln Thr
    130                 135                 140                 
Asn Leu Asp Glu Asp Gly Ala Ser Ala Leu Phe Asp Met Ile Glu Tyr
145                 150                 155                 160 
Tyr Glu Ser Ala Thr His Leu Asn Ile Ser Phe Asn Lys His Ile Gly
                165                 170                 175     
Thr Arg Gly Trp
            180 


<210> 7500
<211> 1412
<212> PRT
<213> Homo sapiens

<400> 7500
Met Met Arg Gly Val Glu Gly Pro Gln Gly Ser Pro Arg Pro Pro Ala
 1               5                  10                  15      
Pro Ile Gln Gln Leu Asn Arg Ser Ser Ser Glu Arg Asp Gly Pro Pro
            20                  25                  30          
Val Glu Asn Glu Met Phe Phe Cys Gln His Cys Asp Tyr Gly Asn Arg
        35                  40                  45              
Thr Val Lys Gly Val Leu Ile His Tyr Gln Lys Lys His Arg Asp Phe
    50                  55                  60                  
Lys Ala Asn Ala Asp Val Ile Arg Gln His Thr Ala Thr Ile Arg Ser
65                  70                  75                  80  
Leu Cys Asp Arg Asn Gln Lys Lys Pro Ala Ser Cys Val Leu Val Ser
                85                  90                  95      
Pro Ser Asn Leu Glu Arg Asp Lys Thr Lys Leu Arg Ala Leu Lys Cys
            100                 105                 110         
Arg Gln Cys Ser Tyr Thr Ser Pro Tyr Phe Tyr Ala Leu Arg Lys His
        115                 120                 125             
Ile Lys Lys Asp His Pro Ala Leu Lys Ala Thr Val Thr Ser Ile Met
    130                 135                 140                 
Arg Trp Ala Phe Leu Asp Gly Leu Ile Glu Ala Gly Tyr His Cys Glu
145                 150                 155                 160 
Trp Cys Ile Tyr Ser His Thr Glu Pro Asn Gly Leu Leu Leu His Tyr
                165                 170                 175     
Gln Arg Arg His Pro Glu His Tyr Val Asp Tyr Thr Tyr Met Ala Thr
            180                 185                 190         
Lys Leu Trp Ala Gly Pro Asp Pro Ser Pro Pro Ser Leu Thr Met Pro
        195                 200                 205             
Ala Glu Ala Lys Thr Tyr Arg Cys Arg Asp Cys Val Phe Glu Ala Val
    210                 215                 220                 
Ser Ile Trp Asp Ile Thr Asn His Tyr Gln Ala Phe His Pro Trp Ala
225                 230                 235                 240 
Met Asn Gly Asp Glu Ser Val Leu Leu Asp Ile Ile Lys Glu Lys Asp
                245                 250                 255     
Ala Val Glu Lys Pro Ile Leu Ser Ser Glu Glu Leu Ala Gly Pro Val
            260                 265                 270         
Asn Cys Glu Asn Ser Ile Pro Thr Pro Phe Pro Glu Gln Glu Ala Glu
        275                 280                 285             
Cys Pro Glu Asp Ala Arg Leu Ser Pro Glu Lys Ser Leu Gln Leu Ala
    290                 295                 300                 
Ser Ala Asn Pro Ala Ile Ser Ser Thr Pro Tyr Gln Cys Thr Val Cys
305                 310                 315                 320 
Gln Ser Glu Tyr Asn Asn Leu His Gly Leu Leu Thr His Tyr Gly Lys
                325                 330                 335     
Lys His Pro Gly Met Lys Val Lys Ala Ala Asp Phe Ala Gln Asp Ile
            340                 345                 350         
Asp Ile Asn Pro Gly Ala Val Tyr Lys Cys Arg His Cys Pro Tyr Ile
        355                 360                 365             
Asn Thr Arg Ile His Gly Val Leu Thr His Tyr Gln Lys Arg His Pro
    370                 375                 380                 
Ser Ile Lys Val Thr Ala Glu Asp Phe Val His Asp Val Glu Gln Ser
385                 390                 395                 400 
Ala Asp Ile Ser Gln Asn Asp Val Glu Glu Thr Ser Arg Ile Phe Lys
                405                 410                 415     
Gln Gly Tyr Gly Ala Tyr Arg Cys Lys Leu Cys Pro Tyr Thr His Gly
            420                 425                 430         
Thr Leu Glu Lys Leu Lys Ile His Tyr Glu Lys Tyr His Asn Gln Pro
        435                 440                 445             
Glu Phe Asp Val Phe Ser Gln Ser Pro Pro Lys Leu Pro Val Pro Leu
    450                 455                 460                 
Glu Pro Glu Met Thr Thr Glu Val Ser Pro Ser Gln Val Ser Ile Thr
465                 470                 475                 480 
Glu Glu Glu Val Gly Glu Glu Pro Val Ser Thr Ser His Phe Ser Thr
                485                 490                 495     
Ser His Leu Val Ser His Thr Val Phe Arg Cys Gln Leu Cys Lys Tyr
            500                 505                 510         
Phe Cys Ser Thr Arg Lys Gly Ile Ala Arg His Tyr Arg Ile Lys His
        515                 520                 525             
Asn Asn Val Arg Ala Gln Pro Glu Gly Lys Asn Asn Leu Phe Lys Cys
    530                 535                 540                 
Ala Leu Cys Ala Tyr Thr Asn Pro Ile Arg Lys Gly Leu Ala Ala His
545                 550                 555                 560 
Tyr Gln Lys Arg His Asp Ile Asp Ala Tyr Tyr Thr His Cys Leu Ala
                565                 570                 575     
Ala Ser Arg Thr Ile Ser Asp Lys Pro Asn Lys Val Ile Ile Pro Ser
            580                 585                 590         
Pro Pro Lys Asp Asp Ser Pro Gln Leu Ser Glu Glu Leu Arg Arg Ala
        595                 600                 605             
Val Glu Lys Lys Lys Cys Ser Leu Cys Ser Phe Gln Ser Phe Ser Lys
    610                 615                 620                 
Lys Gly Ile Val Ser His Tyr Met Lys Arg His Pro Gly Val Phe Pro
625                 630                 635                 640 
Lys Lys Gln His Ala Ser Lys Leu Gly Gly Tyr Phe Thr Ala Val Tyr
                645                 650                 655     
Ala Asp Glu His Glu Lys Pro Thr Leu Met Glu Glu Glu Glu Arg Gly
            660                 665                 670         
Asn Phe Glu Lys Ala Glu Val Glu Gly Glu Ala Gln Glu Ile Glu Trp
        675                 680                 685             
Leu Pro Phe Arg Cys Ile Lys Cys Phe Lys Leu Ser Phe Ser Thr Ala
    690                 695                 700                 
Glu Leu Leu Cys Met His Tyr Thr Asp His His Ser Arg Asp Leu Lys
705                 710                 715                 720 
Arg Asp Phe Ile Ile Leu Gly Asn Gly Pro Arg Leu Gln Asn Ser Thr
                725                 730                 735     
Tyr Gln Cys Lys His Cys Asp Ser Lys Leu Gln Ser Thr Ala Glu Leu
            740                 745                 750         
Thr Ser His Leu Asn Ile His Asn Glu Glu Phe Gln Lys Arg Ala Lys
        755                 760                 765             
Arg Gln Glu Arg Arg Lys Gln Leu Leu Ser Lys Gln Lys Tyr Ala Asp
    770                 775                 780                 
Gly Ala Phe Ala Asp Phe Lys Gln Glu Arg Pro Phe Gly His Leu Glu
785                 790                 795                 800 
Glu Val Pro Lys Ile Lys Glu Arg Lys Val Val Gly Tyr Lys Cys Lys
                805                 810                 815     
Phe Cys Val Glu Val His Pro Thr Leu Arg Ala Ile Cys Asn His Leu
            820                 825                 830         
Arg Lys His Val Gln Tyr Gly Asn Val Pro Ala Val Ser Ala Ala Val
        835                 840                 845             
Lys Gln Glu Ala Asp Asp Pro Ala His Leu Phe Leu Asp Gly Leu Glu
    850                 855                 860                 
Ala Ala Lys Asp Ala Ser Gly Ala Leu Val Gly Arg Val Asp Gly Glu
865                 870                 875                 880 
His Cys Leu Leu Asp Gly Met Leu Glu Asp Glu Thr Arg Pro Gly Gly
                885                 890                 895     
Tyr His Cys Ser Gln Cys Asp Arg Val Leu Met Ser Met Gln Gly Leu
            900                 905                 910         
Arg Ser His Glu Arg Ser His Leu Ala Leu Ala Met Phe Thr Arg Glu
        915                 920                 925             
Asp Lys Tyr Ser Cys Gln Tyr Cys Ser Phe Val Ser Ala Phe Arg His
    930                 935                 940                 
Asn Leu Asp Arg His Met Gln Thr His His Gly His His Lys Pro Phe
945                 950                 955                 960 
Arg Cys Lys Leu Cys Ser Phe Lys Ser Ser Tyr Asn Ser Arg Leu Lys
                965                 970                 975     
Thr His Ile Leu Lys Ala His Ala Gly Glu His Ala Tyr Lys Cys Ser
            980                 985                 990         
Trp Cys Ser Phe Ser Thr Met Thr Ile Ser Gln Leu Lys Glu His Ser
        995                 1000                1005            
Leu Lys Val His Gly Lys Ala Leu Thr Leu Pro Arg Pro Arg Ile Val
    1010                1015                1020                
Ser Leu Leu Ser Ser His Ser His His Ser Ser Gln Lys Ala Thr Pro
1025                1030                1035                1040
Ala Glu Glu Val Glu Asp Ser Asn Asp Ser Ser Tyr Ser Glu Pro Pro
                1045                1050                1055    
Asp Val Gln Gln Gln Leu Asn His Tyr Gln Ser Ala Ala Leu Ala Arg
            1060                1065                1070        
Asn Asn Ser Arg Val Ser Pro Val Pro Leu Ser Gly Ala Ala Ala Gly
        1075                1080                1085            
Thr Glu Gln Lys Thr Glu Ala Val Leu His Cys Glu Phe Cys Glu Phe
    1090                1095                1100                
Ser Ser Gly Tyr Ile Gln Ser Ile Arg Arg His Tyr Arg Asp Lys His
1105                1110                1115                1120
Gly Gly Lys Lys Leu Phe Lys Cys Lys Asp Cys Ser Phe Tyr Thr Gly
                1125                1130                1135    
Phe Lys Ser Ala Phe Thr Met His Val Glu Ala Gly His Ser Ala Val
            1140                1145                1150        
Pro Glu Glu Gly Pro Lys Asp Leu Arg Cys Pro Leu Cys Leu Tyr His
        1155                1160                1165            
Thr Lys Tyr Lys Arg Asn Met Ile Asp His Ile Val Leu His Arg Glu
    1170                1175                1180                
Glu Arg Val Val Pro Ile Glu Val Cys Arg Ser Lys Leu Ser Lys Tyr
1185                1190                1195                1200
Leu Gln Gly Val Val Phe Arg Cys Asp Lys Cys Thr Phe Thr Cys Ser
                1205                1210                1215    
Ser Asp Glu Ser Leu Gln Gln His Ile Glu Lys His Asn Glu Leu Lys
            1220                1225                1230        
Pro Tyr Lys Cys Gln Leu Cys Tyr Tyr Glu Thr Lys His Thr Glu Glu
        1235                1240                1245            
Leu Asp Ser His Leu Arg Asp Glu His Lys Val Ser Arg Asn Phe Glu
    1250                1255                1260                
Leu Val Gly Arg Val Asn Leu Asp Gln Leu Glu Gln Met Lys Glu Lys
1265                1270                1275                1280
Met Glu Ser Ser Ser Ser Asp Asp Glu Asp Lys Glu Glu Glu Met Asn
                1285                1290                1295    
Ser Lys Ala Glu Asp Arg Glu Leu Met Arg Phe Ser Asp His Gly Ala
            1300                1305                1310        
Ala Leu Asn Thr Glu Lys Arg Phe Pro Cys Glu Phe Cys Gly Arg Ala
        1315                1320                1325            
Phe Ser Gln Gly Ser Glu Trp Glu Arg His Val Leu Arg His Gly Met
    1330                1335                1340                
Ala Leu Asn Asp Thr Lys Gln Val Ser Arg Glu Glu Ile His Pro Lys
1345                1350                1355                1360
Glu Ile Met Glu Asn Ser Val Lys Met Pro Ser Ile Glu Glu Lys Glu
                1365                1370                1375    
Asp Asp Glu Ala Ile Gly Ile Asp Phe Ser Leu Lys Asn Glu Thr Val
            1380                1385                1390        
Ala Ile Cys Val Val Thr Ala Asp Lys Ser Leu Leu Glu Asn Ala Glu
        1395                1400                1405            
Ala Lys Lys Glu
    1410        


<210> 7501
<211> 853
<212> PRT
<213> Homo sapiens

<400> 7501
Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys
 1               5                  10                  15      
Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met
            20                  25                  30          
Asp Thr Ser Thr Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp
        35                  40                  45              
Leu Glu Lys Ser Thr Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly
    50                  55                  60                  
Glu Ser Phe Gly Gly Glu Thr Ser Asn Ser Gly Asp Pro His Lys Gly
65                  70                  75                  80  
Phe Ser Val Asp Tyr Tyr Asn Thr Thr Thr Lys Gly Thr Pro Glu Arg
                85                  90                  95      
Leu His Phe Glu Met Thr His Lys Glu Ile Pro Cys Gln Gly Pro Arg
            100                 105                 110         
Ala Gln Leu Gly Asn Gly Ser Ser Val Asp Glu Val Ser Phe Tyr Ala
        115                 120                 125             
Asn Arg Leu Thr Asn Leu Val Ile Ala Met Ala Arg Lys Glu Ile Asn
    130                 135                 140                 
Glu Lys Ile Asp Gly Ser Glu Asn Lys Cys Val Tyr Gln Ser Leu Tyr
145                 150                 155                 160 
Met Gly Asn Glu Pro Thr Pro Thr Lys Ser Leu Ser Lys Ile Ala Ser
                165                 170                 175     
Glu Leu Val Asn Glu Thr Val Ser Ala Cys Ser Arg Asn Ala Ala Pro
            180                 185                 190         
Asp Lys Ala Pro Gly Ser Gly Asp Arg Val Ser Gly Ser Ser Gln Ser
        195                 200                 205             
Pro Pro Asn Leu Lys Tyr Lys Ser Thr Leu Lys Ile Lys Glu Ser Thr
    210                 215                 220                 
Lys Glu Arg Gln Gly Pro Asp Asp Lys Pro Pro Ser Lys Lys Ser Phe
225                 230                 235                 240 
Phe Tyr Lys Glu Val Phe Glu Ser Arg Asn Gly Asp Tyr Ala Arg Glu
                245                 250                 255     
Gly Gly Arg Phe Phe Pro Arg Glu Arg Lys Arg Phe Arg Gly Gln Glu
            260                 265                 270         
Arg Pro Asp Asp Phe Thr Ala Ser Val Ser Glu Gly Ile Met Thr Tyr
        275                 280                 285             
Ala Asn Ser Val Val Ser Asp Met Met Val Ser Ile Met Lys Thr Leu
    290                 295                 300                 
Lys Ile Gln Val Lys Asp Thr Thr Ile Ala Thr Ile Leu Leu Lys Lys
305                 310                 315                 320 
Val Leu Leu Lys His Ala Lys Glu Val Val Ser Asp Leu Ile Asp Ser
                325                 330                 335     
Phe Leu Arg Asn Leu His Ser Val Thr Gly Thr Leu Met Thr Asp Thr
            340                 345                 350         
Gln Phe Val Ser Ala Val Lys Arg Thr Val Phe Ser His Gly Ser Gln
        355                 360                 365             
Lys Ala Thr Asp Ile Met Asp Ala Met Leu Arg Lys Leu Tyr Asn Val
    370                 375                 380                 
Met Phe Ala Lys Lys Val Pro Glu His Val Arg Lys Ala Gln Asp Lys
385                 390                 395                 400 
Ala Glu Ser Tyr Ser Leu Ile Ser Met Lys Gly Met Gly Asp Pro Lys
                405                 410                 415     
Asn Arg Asn Val Asn Phe Ala Met Lys Ser Glu Thr Lys Leu Arg Glu
            420                 425                 430         
Lys Met Tyr Ser Glu Pro Lys Ser Glu Glu Glu Thr Cys Ala Lys Thr
        435                 440                 445             
Leu Gly Glu His Ile Ile Lys Glu Gly Leu Thr Leu Trp His Lys Ser
    450                 455                 460                 
Gln Gln Lys Glu Cys Lys Ser Leu Gly Phe Gln His Ala Ala Phe Glu
465                 470                 475                 480 
Ala Pro Asn Thr Gln Arg Lys Pro Ala Ser Asp Ile Ser Phe Glu Tyr
                485                 490                 495     
Pro Glu Asp Ile Gly Asn Leu Ser Leu Pro Pro Tyr Pro Pro Glu Lys
            500                 505                 510         
Pro Glu Asn Phe Met Tyr Asp Ser Asp Ser Trp Ala Lys Asp Leu Ile
        515                 520                 525             
Val Ser Ala Leu Leu Leu Ile Gln Tyr His Leu Ala Gln Gly Gly Arg
    530                 535                 540                 
Arg Asp Ala Arg Ser Phe Val Glu Ala Ala Gly Thr Thr Asn Phe Pro
545                 550                 555                 560 
Ala Asn Glu Pro Pro Val Ala Pro Asp Glu Ser Cys Leu Lys Ser Ala
                565                 570                 575     
Pro Ile Val Gly Asp Gln Glu Gln Ala Glu Lys Lys Asp Leu Arg Ser
            580                 585                 590         
Val Phe Phe Asn Phe Ile Arg Asn Leu Leu Ser Glu Thr Ile Phe Lys
        595                 600                 605             
Arg Asp Gln Ser Pro Glu Pro Lys Val Pro Glu Gln Pro Val Lys Glu
    610                 615                 620                 
Asp Arg Lys Leu Cys Glu Arg Pro Leu Ala Ser Ser Pro Pro Arg Leu
625                 630                 635                 640 
Tyr Glu Asp Asp Glu Thr Pro Gly Ala Leu Ser Gly Leu Thr Lys Met
                645                 650                 655     
Ala Val Ser Gln Ile Asp Gly His Met Ser Gly Gln Met Val Glu His
            660                 665                 670         
Leu Met Asn Ser Val Met Lys Leu Cys Val Ile Ile Ala Lys Ser Cys
        675                 680                 685             
Asp Ala Ser Leu Ala Glu Leu Gly Asp Asp Lys Ser Gly Asp Ala Ser
    690                 695                 700                 
Arg Leu Thr Ser Ala Phe Pro Asp Ser Leu Tyr Glu Cys Leu Pro Ala
705                 710                 715                 720 
Lys Gly Thr Gly Ser Ala Glu Ala Val Leu Gln Asn Ala Tyr Gln Ala
                725                 730                 735     
Ile His Asn Glu Met Arg Gly Thr Ser Gly Gln Pro Pro Glu Gly Cys
            740                 745                 750         
Ala Ala Pro Thr Val Ile Val Ser Asn His Asn Leu Thr Asp Thr Val
        755                 760                 765             
Gln Asn Lys Gln Leu Gln Ala Val Leu Gln Trp Val Ala Ala Ser Glu
    770                 775                 780                 
Leu Asn Val Pro Ile Leu Tyr Phe Ala Gly Asp Asp Glu Gly Ile Gln
785                 790                 795                 800 
Glu Lys Leu Leu Gln Leu Ser Ala Ala Ala Val Asp Lys Gly Cys Ser
                805                 810                 815     
Val Gly Glu Val Leu Gln Ser Val Leu Arg Tyr Glu Lys Glu Arg Gln
            820                 825                 830         
Leu Asn Glu Ala Val Gly Asn Val Thr Pro Leu Gln Leu Leu Asp Trp
        835                 840                 845             
Leu Met Val Asn Leu
    850             


<210> 7502
<211> 336
<212> PRT
<213> Homo sapiens

<400> 7502
Met Asp Cys Val Gly Trp Pro Pro Gly Arg Lys Trp His Leu Glu Lys
 1               5                  10                  15      
Asn Thr Ser Cys Gly Gly Ser Ser Gly Ile Cys Ala Ser Tyr Val Thr
            20                  25                  30          
Gln Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp
        35                  40                  45              
Ser Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe
    50                  55                  60                  
Val Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser
65                  70                  75                  80  
Ile Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn
                85                  90                  95      
Phe Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp
            100                 105                 110         
Lys Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu
        115                 120                 125             
Ala Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr
    130                 135                 140                 
Asn Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser
145                 150                 155                 160 
Glu Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser
                165                 170                 175     
His Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile
            180                 185                 190         
Lys Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu
        195                 200                 205             
Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu
    210                 215                 220                 
Asp Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala
225                 230                 235                 240 
Asn Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr
                245                 250                 255     
Ser Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser
            260                 265                 270         
Trp Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp
        275                 280                 285             
Leu Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg
    290                 295                 300                 
His Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln
305                 310                 315                 320 
Ile Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln
                325                 330                 335     


<210> 7503
<211> 303
<212> PRT
<213> Homo sapiens

<400> 7503
Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser
 1               5                  10                  15      
Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val
            20                  25                  30          
Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile
        35                  40                  45              
Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe
    50                  55                  60                  
Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys
65                  70                  75                  80  
Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala
                85                  90                  95      
Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn
            100                 105                 110         
Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu
        115                 120                 125             
Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His
    130                 135                 140                 
Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys
145                 150                 155                 160 
Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu
                165                 170                 175     
Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp
            180                 185                 190         
Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn
        195                 200                 205             
Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser
    210                 215                 220                 
Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp
225                 230                 235                 240 
Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu
                245                 250                 255     
Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His
            260                 265                 270         
Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile
        275                 280                 285             
Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln
    290                 295                 300             


<210> 7504
<211> 1586
<212> PRT
<213> Homo sapiens

<400> 7504
Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser
 1               5                  10                  15      
Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly
            20                  25                  30          
Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro
        35                  40                  45              
Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp
    50                  55                  60                  
Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile
65                  70                  75                  80  
His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly
                85                  90                  95      
Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro
            100                 105                 110         
Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu
        115                 120                 125             
Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr
    130                 135                 140                 
Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp
145                 150                 155                 160 
Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro
                165                 170                 175     
Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu
            180                 185                 190         
Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly
        195                 200                 205             
Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln
    210                 215                 220                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro
225                 230                 235                 240 
Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu Val Asn Tyr Asn
                245                 250                 255     
Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro Ser Thr Pro Gln
            260                 265                 270         
Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser Pro Ala Pro Pro
        275                 280                 285             
Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly Pro Ser Val Pro
    290                 295                 300                 
Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln Leu Gln Gln Lys
305                 310                 315                 320 
Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly Leu Asp Pro Val
                325                 330                 335     
Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His
            340                 345                 350         
Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu Pro Pro Asp Leu
        355                 360                 365             
Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe
    370                 375                 380                 
Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met Arg Arg Asp Thr
385                 390                 395                 400 
Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys Arg Ser Lys Arg
                405                 410                 415     
Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu Glu Lys Gln Gln
            420                 425                 430         
Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu
        435                 440                 445             
Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser
    450                 455                 460                 
Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val Ala Thr Trp His
465                 470                 475                 480 
Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu Arg Ile Glu Lys
                485                 490                 495     
Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys
            500                 505                 510         
Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr Leu Leu Gln Gln
        515                 520                 525             
Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val Trp Glu His Lys
    530                 535                 540                 
Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg Arg Arg Lys Lys
545                 550                 555                 560 
Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala Leu Gly Pro Asp
                565                 570                 575     
Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp Leu Pro Val Lys
            580                 585                 590         
Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly Pro Glu Ala Pro
        595                 600                 605             
Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu
    610                 615                 620                 
Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser Asp Tyr Glu Glu
625                 630                 635                 640 
Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr Glu Glu Lys Ile
                645                 650                 655     
Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys Asp Ala Lys Gln
            660                 665                 670         
Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu Tyr Ser Met Gln
        675                 680                 685             
Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val Ala His Ala Ile
    690                 695                 700                 
Ser Glu Trp Val Glu Lys Gln Ser Ala Leu Leu Ile Asn Gly Thr Leu
705                 710                 715                 720 
Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val Ser Leu Tyr Asn
                725                 730                 735     
Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr
            740                 745                 750         
Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys Arg Leu
        755                 760                 765             
Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr Leu Ser Asn Trp
    770                 775                 780                 
Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Ile Ser Tyr
785                 790                 795                 800 
Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro Gln Leu Arg Ser
                805                 810                 815     
Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile Lys Asp
            820                 825                 830         
Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val Asp Glu
        835                 840                 845             
Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val Leu Asn
    850                 855                 860                 
Thr His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr Gly Thr Pro Leu
865                 870                 875                 880 
Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu Leu Pro
                885                 890                 895     
Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn Ala Pro
            900                 905                 910         
Phe Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu Glu Glu Thr Ile
        915                 920                 925             
Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu Leu Arg
    930                 935                 940                 
Arg Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu Lys Val Glu Tyr
945                 950                 955                 960 
Val Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile Leu Tyr Arg His
                965                 970                 975     
Met Gln Ala Lys Gly Ile Leu Leu Thr Asp Gly Ser Glu Lys Asp Lys
            980                 985                 990         
Lys Gly Lys Gly Gly Ala Lys Thr Leu Met Asn Thr Ile Met Gln Leu
        995                 1000                1005            
Arg Lys Ile Cys Asn His Pro Tyr Met Phe Gln His Ile Glu Glu Ser
    1010                1015                1020                
Phe Ala Glu His Leu Gly Tyr Ser Asn Gly Val Ile Asn Gly Ala Glu
1025                1030                1035                1040
Leu Tyr Arg Ala Ser Gly Lys Phe Glu Leu Leu Asp Arg Ile Leu Pro
                1045                1050                1055    
Lys Leu Arg Ala Thr Asn His Arg Val Leu Leu Phe Cys Gln Met Thr
            1060                1065                1070        
Ser Leu Met Thr Ile Met Glu Asp Tyr Phe Ala Phe Arg Asn Phe Leu
        1075                1080                1085            
Tyr Leu Arg Leu Asp Gly Thr Thr Lys Ser Glu Asp Arg Ala Ala Leu
    1090                1095                1100                
Leu Lys Lys Phe Asn Glu Pro Gly Ser Gln Tyr Phe Ile Phe Leu Leu
1105                1110                1115                1120
Ser Thr Arg Ala Gly Gly Leu Gly Leu Asn Leu Gln Ala Ala Asp Thr
                1125                1130                1135    
Val Val Ile Phe Asp Ser Asp Trp Asn Pro His Gln Asp Leu Gln Ala
            1140                1145                1150        
Gln Asp Arg Ala His Arg Ile Gly Gln Gln Asn Glu Val Arg Val Leu
        1155                1160                1165            
Arg Leu Cys Thr Val Asn Ser Val Glu Glu Lys Ile Leu Ala Ala Ala
    1170                1175                1180                
Lys Tyr Lys Leu Asn Val Asp Gln Lys Val Ile Gln Ala Gly Met Phe
1185                1190                1195                1200
Asp Gln Lys Ser Ser Ser His Glu Arg Arg Ala Phe Leu Gln Ala Ile
                1205                1210                1215    
Leu Glu His Glu Glu Glu Asn Glu Glu Glu Asp Glu Val Pro Asp Asp
            1220                1225                1230        
Glu Thr Leu Asn Gln Met Ile Ala Arg Arg Glu Glu Glu Phe Asp Leu
        1235                1240                1245            
Phe Met Arg Met Asp Met Asp Arg Arg Arg Glu Asp Ala Arg Asn Pro
    1250                1255                1260                
Lys Arg Lys Pro Arg Leu Met Glu Glu Asp Glu Leu Pro Ser Trp Ile
1265                1270                1275                1280
Ile Lys Asp Asp Ala Glu Val Glu Arg Leu Thr Cys Glu Glu Glu Glu
                1285                1290                1295    
Glu Lys Ile Phe Gly Arg Gly Ser Arg Gln Arg Arg Asp Val Asp Tyr
            1300                1305                1310        
Ser Asp Ala Leu Thr Glu Lys Gln Trp Leu Arg Ala Ile Glu Asp Gly
        1315                1320                1325            
Asn Leu Glu Glu Met Glu Glu Glu Val Arg Leu Lys Lys Arg Lys Arg
    1330                1335                1340                
Arg Arg Asn Val Asp Lys Asp Pro Ala Lys Glu Asp Val Glu Lys Ala
1345                1350                1355                1360
Lys Lys Arg Arg Gly Arg Pro Pro Ala Glu Lys Leu Ser Pro Asn Pro
                1365                1370                1375    
Pro Lys Leu Thr Lys Gln Met Asn Ala Ile Ile Asp Thr Cys Ile Asn
            1380                1385                1390        
Tyr Lys Asp Ser Cys Asn Val Glu Lys Val Pro Ser Asn Ser Gln Leu
        1395                1400                1405            
Glu Ile Glu Gly Asn Ser Ser Gly Arg Gln Leu Ser Glu Val Phe Ile
    1410                1415                1420                
Gln Leu Pro Ser Arg Lys Glu Leu Pro Glu Tyr Tyr Glu Leu Ile Arg
1425                1430                1435                1440
Lys Pro Val Asp Phe Lys Lys Ile Lys Glu Arg Ile Arg Asn His Lys
                1445                1450                1455    
Tyr Arg Ser Leu Gly Asp Leu Glu Lys Asp Val Met Leu Leu Cys His
            1460                1465                1470        
Asn Ala Gln Thr Phe Asn Leu Glu Gly Ser Gln Ile Tyr Glu Asp Ser
        1475                1480                1485            
Ile Val Leu Gln Ser Val Phe Lys Ser Ala Arg Gln Lys Ile Ala Lys
    1490                1495                1500                
Glu Glu Glu Ser Glu Asp Glu Ser Asn Glu Glu Glu Glu Glu Glu Asp
1505                1510                1515                1520
Glu Glu Glu Ser Glu Ser Glu Ala Lys Ser Val Lys Val Lys Ile Lys
                1525                1530                1535    
Leu Asn Lys Lys Asp Asp Lys Gly Arg Asp Lys Gly Lys Gly Lys Lys
            1540                1545                1550        
Arg Pro Asn Arg Gly Lys Ala Lys Pro Val Val Ser Asp Phe Asp Ser
        1555                1560                1565            
Asp Glu Glu Gln Asp Glu Arg Glu Gln Ser Glu Gly Ser Gly Thr Asp
    1570                1575                1580                
Asp Glu
1585    


<210> 7505
<211> 1023
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 311, 970
<223> Xaa = Any Amino Acid

<400> 7505
Met Ala Gly Pro Val Ser Leu Arg Asp Leu Leu Met Gly Ala Ser Ala
 1               5                  10                  15      
Trp Met Gly Ser Glu Ser Pro Gly Gly Ser Pro Thr Glu Gly Gly Gly
            20                  25                  30          
Ser Ala Ala Gly Gly Pro Glu Pro Pro Trp Arg Glu Asp Glu Ile Cys
        35                  40                  45              
Val Val Gly Ile Phe Gly Lys Thr Ala Leu Arg Leu Asn Ser Glu Lys
    50                  55                  60                  
Phe Ser Leu Val Asn Thr Val Cys Asp Arg Gln Val Phe Pro Leu Phe
65                  70                  75                  80  
Arg His Gln Asp Pro Gly Asp Pro Gly Pro Gly Ile Arg Thr Glu Ala
                85                  90                  95      
Gly Ala Val Gly Glu Ala Gly Gly Ala Glu Asp Pro Gly Ala Ala Ala
            100                 105                 110         
Gly Gly Ser Val Arg Gly Ser Gly Ala Val Ala Glu Gly Asn Arg Thr
        115                 120                 125             
Glu Ala Gly Ser Gln Asp Tyr Ser Leu Leu Gln Ala Tyr Tyr Ser Gln
    130                 135                 140                 
Glu Ser Lys Val Leu Tyr Leu Leu Leu Thr Ser Ile Cys Asp Asn Ser
145                 150                 155                 160 
Gln Leu Leu Arg Ala Cys Arg Ala Leu Gln Ser Gly Glu Ala Gly Gly
                165                 170                 175     
Gly Leu Ser Leu Pro His Ala Glu Ala His Glu Phe Trp Lys His Gln
            180                 185                 190         
Glu Lys Leu Gln Cys Leu Ser Leu Leu Tyr Leu Phe Ser Val Cys His
        195                 200                 205             
Ile Leu Leu Leu Val His Pro Thr Cys Ser Phe Asp Ile Thr Tyr Asp
    210                 215                 220                 
Arg Val Phe Arg Ala Leu Asp Gly Leu Arg Gln Lys Val Leu Pro Leu
225                 230                 235                 240 
Leu Lys Thr Ala Ile Lys Asp Cys Pro Val Gly Lys Asp Trp Lys Leu
                245                 250                 255     
Asn Cys Arg Pro Cys Pro Pro Arg Leu Leu Phe Leu Phe Gln Leu Asn
            260                 265                 270         
Gly Ala Leu Lys Val Glu Pro Pro Arg Asn Gln Asp Pro Ala His Pro
        275                 280                 285             
Asp Lys Pro Lys Lys His Ser Pro Lys Arg Arg Leu Gln His Ala Leu
    290                 295                 300                 
Glu Asp Gln Ile Tyr Arg Xaa Phe Arg Lys Ser Arg Val Leu Thr Asn
305                 310                 315                 320 
Gln Ser Ile Asn Cys Leu Phe Thr Val Pro Ala Asn Gln Ala Phe Val
                325                 330                 335     
Tyr Ile Val Pro Gly Ser Gln Glu Glu Asp Pro Val Gly Met Leu Leu
            340                 345                 350         
Asp Gln Leu Arg Ser His Cys Thr Val Lys Asp Pro Glu Ser Leu Leu
        355                 360                 365             
Val Pro Ala Pro Leu Ser Gly Pro Arg Arg Tyr Gln Val Met Arg Gln
    370                 375                 380                 
His Ser Arg Gln Gln Leu Ser Phe His Ile Asp Ser Ser Ser Ser Ser
385                 390                 395                 400 
Ser Ser Gly Gln Leu Val Asp Phe Thr Leu Arg Glu Phe Leu Trp Gln
                405                 410                 415     
His Val Glu Leu Val Leu Ser Lys Lys Gly Phe Asp Asp Ser Val Gly
            420                 425                 430         
Arg Asn Pro Gln Pro Ser His Phe Glu Leu Pro Thr Tyr Gln Lys Trp
        435                 440                 445             
Ile Ser Ala Ala Ser Lys Leu Tyr Glu Val Ala Ile Asp Gly Lys Glu
    450                 455                 460                 
Glu Asp Leu Gly Ser Pro Thr Gly Glu Leu Thr Ser Lys Ile Leu Ser
465                 470                 475                 480 
Ser Ile Lys Val Leu Glu Gly Leu Leu Asp Phe Asp Pro Lys Phe Ser
                485                 490                 495     
Glu Asn Arg Cys Gln Lys Ala Leu Pro Met Ala His Ser Ala Tyr Gln
            500                 505                 510         
Ser Asn Leu Pro His Asn Tyr Pro Met Pro Val His Lys Asn Gln Leu
        515                 520                 525             
Ala Gln Ala Arg Arg Val Tyr Ser Gln His Ala Arg Gly Pro Ala Phe
    530                 535                 540                 
His Lys Tyr Ala Met Gln Leu His Glu Asp Cys Tyr Lys Phe Trp Ser
545                 550                 555                 560 
Asn Gly His Gln Leu Cys Glu Glu Arg Ser Leu Thr Asp Gln His Cys
                565                 570                 575     
Val His Lys Phe His Ser Leu Pro Lys Ser Gly Glu Lys Pro Glu Ala
            580                 585                 590         
Asp Arg Asn Pro Pro Val Leu Tyr His Asn Ser Arg Ala Arg Ser Thr
        595                 600                 605             
Gly Ala Cys Asn Cys Gly Arg Lys Gln Ala Pro Arg Asp Asp Pro Phe
    610                 615                 620                 
Asp Ile Lys Ala Ala Asn Tyr Asp Phe Tyr Gln Leu Leu Glu Glu Lys
625                 630                 635                 640 
Cys Cys Gly Lys Leu Asp His Ile Asn Phe Pro Val Phe Glu Pro Ser
                645                 650                 655     
Thr Pro Asp Pro Ala Pro Ala Lys Asn Glu Ser Ser Pro Ala Pro Pro
            660                 665                 670         
Asp Ser Asp Ala Asp Lys Leu Lys Glu Lys Glu Pro Gln Thr Gln Gly
        675                 680                 685             
Glu Ser Thr Ser Leu Ser Leu Ala Leu Ser Leu Gly Gln Ser Thr Asp
    690                 695                 700                 
Ser Leu Gly Thr Tyr Pro Ala Asp Pro Gln Ala Gly Gly Asp Asn Pro
705                 710                 715                 720 
Glu Val His Gly Gln Val Glu Val Lys Thr Glu Lys Arg Pro Asn Phe
                725                 730                 735     
Val Asp Arg Gln Ala Ser Thr Val Glu Tyr Leu Pro Gly Met Leu His
            740                 745                 750         
Ser Asn Cys Pro Lys Gly Leu Leu Pro Lys Phe Ser Ser Trp Ser Leu
        755                 760                 765             
Val Lys Leu Gly Pro Ala Lys Ser Tyr Asn Phe His Thr Gly Leu Asp
    770                 775                 780                 
Gln Gln Gly Phe Ile Pro Gly Thr Asn Tyr Leu Met Pro Trp Asp Ile
785                 790                 795                 800 
Val Ile Arg Thr Arg Ala Glu Asp Glu Gly Asp Leu Asp Thr Asn Ser
                805                 810                 815     
Trp Pro Ala Pro Asn Lys Ala Ile Pro Gly Lys Arg Ser Ala Val Val
            820                 825                 830         
Met Gly Arg Gly Arg Arg Arg Asp Asp Ile Ala Arg Ala Phe Val Gly
        835                 840                 845             
Phe Glu Tyr Glu Asp Ser Arg Gly Arg Arg Phe Met Cys Ser Gly Pro
    850                 855                 860                 
Asp Lys Val Met Lys Val Met Gly Ser Gly Pro Lys Glu Ser Ala Leu
865                 870                 875                 880 
Lys Ala Leu Asn Ser Asp Met Pro Leu Tyr Ile Leu Ser Ser Ser Gln
                885                 890                 895     
Gly Arg Gly Leu Lys Pro His Tyr Ala Gln Leu Met Arg Leu Phe Val
            900                 905                 910         
Val Val Pro Asp Ala Pro Leu Gln Ile Ile Leu Met Pro Gln Val Gln
        915                 920                 925             
Pro Gly Pro Pro Pro Cys Pro Val Phe Tyr Pro Glu Lys Gln Glu Ile
    930                 935                 940                 
Thr Leu Pro Pro Asp Gly Leu Trp Val Leu Arg Phe Pro Tyr Ala Tyr
945                 950                 955                 960 
Gly Leu Arg Glu Asp Leu Val Ser Pro Xaa Gly Lys Lys Gln Glu Ile
                965                 970                 975     
Pro Leu Pro Pro Asp Gly Leu Trp Val Leu Arg Phe Pro Tyr Ala Tyr
            980                 985                 990         
Val Thr Glu Arg Gly Pro Cys Phe Pro Pro Lys Glu Asn Val Gln Leu
        995                 1000                1005            
Met Ser Tyr Lys Val Leu Arg Gly Val Leu Lys Ala Val Thr Gln
    1010                1015                1020            


<210> 7506
<211> 991
<212> PRT
<213> Homo sapiens

<400> 7506
Met Ala Gly Pro Val Ser Leu Arg Asp Leu Leu Met Gly Ala Ser Ala
 1               5                  10                  15      
Trp Met Gly Ser Glu Ser Pro Gly Gly Ser Pro Thr Glu Gly Gly Gly
            20                  25                  30          
Ser Ala Ala Gly Gly Pro Glu Pro Pro Trp Arg Glu Asp Glu Ile Cys
        35                  40                  45              
Val Val Gly Ile Phe Gly Lys Thr Ala Leu Arg Leu Asn Ser Glu Lys
    50                  55                  60                  
Phe Ser Leu Val Asn Thr Val Cys Asp Arg Gln Val Phe Pro Leu Phe
65                  70                  75                  80  
Arg His Gln Asp Pro Gly Asp Pro Gly Pro Gly Ile Arg Thr Glu Ala
                85                  90                  95      
Gly Ala Val Gly Glu Ala Gly Gly Ala Glu Asp Pro Gly Ala Ala Ala
            100                 105                 110         
Gly Gly Ser Val Arg Gly Ser Gly Ala Val Ala Glu Gly Asn Arg Thr
        115                 120                 125             
Glu Ala Gly Ser Gln Asp Tyr Ser Leu Leu Gln Ala Tyr Tyr Ser Gln
    130                 135                 140                 
Glu Ser Lys Val Leu Tyr Leu Leu Leu Thr Ser Ile Cys Asp Asn Ser
145                 150                 155                 160 
Gln Leu Leu Arg Ala Cys Arg Ala Leu Gln Ser Gly Glu Ala Gly Gly
                165                 170                 175     
Gly Leu Ser Leu Pro His Ala Glu Ala His Glu Phe Trp Lys His Gln
            180                 185                 190         
Glu Lys Leu Gln Cys Leu Ser Leu Leu Tyr Leu Phe Ser Val Cys His
        195                 200                 205             
Ile Leu Leu Leu Val His Pro Thr Cys Ser Phe Asp Ile Thr Tyr Asp
    210                 215                 220                 
Arg Val Phe Arg Ala Leu Asp Gly Leu Arg Gln Lys Val Leu Pro Leu
225                 230                 235                 240 
Leu Lys Thr Ala Ile Lys Asp Cys Pro Val Gly Lys Asp Trp Lys Leu
                245                 250                 255     
Asn Cys Arg Pro Cys Pro Pro Arg Leu Leu Phe Leu Phe Gln Leu Asn
            260                 265                 270         
Gly Ala Leu Lys Val Glu Pro Pro Arg Asn Gln Asp Pro Ala His Pro
        275                 280                 285             
Asp Lys Pro Lys Lys His Ser Pro Lys Arg Arg Leu Gln His Ala Leu
    290                 295                 300                 
Glu Asp Gln Ile Tyr Arg Ile Phe Arg Lys Ser Arg Val Leu Thr Asn
305                 310                 315                 320 
Gln Ser Ile Asn Cys Leu Phe Thr Val Pro Ala Asn Gln Ala Phe Val
                325                 330                 335     
Tyr Ile Val Pro Gly Ser Gln Glu Glu Asp Pro Val Gly Met Leu Leu
            340                 345                 350         
Asp Gln Leu Arg Ser His Cys Thr Val Lys Asp Pro Glu Ser Leu Leu
        355                 360                 365             
Val Pro Ala Pro Leu Ser Gly Pro Arg Arg Tyr Gln Val Met Arg Gln
    370                 375                 380                 
His Ser Arg Gln Gln Leu Ser Phe His Ile Asp Ser Ser Ser Ser Ser
385                 390                 395                 400 
Ser Ser Gly Gln Leu Val Asp Phe Thr Leu Arg Glu Phe Leu Trp Gln
                405                 410                 415     
His Val Glu Leu Val Leu Ser Lys Lys Gly Phe Asp Asp Ser Val Gly
            420                 425                 430         
Arg Asn Pro Gln Pro Ser His Phe Glu Leu Pro Thr Tyr Gln Lys Trp
        435                 440                 445             
Ile Ser Ala Ala Ser Lys Leu Tyr Glu Val Ala Ile Asp Gly Lys Glu
    450                 455                 460                 
Glu Asp Leu Gly Ser Pro Thr Gly Glu Leu Thr Ser Lys Ile Leu Ser
465                 470                 475                 480 
Ser Ile Lys Val Leu Glu Gly Phe Leu Asp Ile Asp Thr Lys Phe Ser
                485                 490                 495     
Glu Asn Arg Cys Gln Lys Ala Leu Pro Met Ala His Ser Ala Tyr Gln
            500                 505                 510         
Ser Asn Leu Pro His Asn Tyr Thr Met Thr Val His Lys Asn Gln Leu
        515                 520                 525             
Ala Gln Ala Leu Arg Val Tyr Ser Gln His Ala Arg Gly Pro Ala Phe
    530                 535                 540                 
His Lys Tyr Ala Met Gln Leu His Glu Asp Cys Tyr Lys Phe Trp Ser
545                 550                 555                 560 
Asn Gly His Gln Leu Cys Glu Glu Arg Ser Leu Thr Asp Gln His Cys
                565                 570                 575     
Val His Lys Phe His Ser Leu Pro Lys Ser Gly Glu Lys Pro Glu Ala
            580                 585                 590         
Asp Arg Asn Pro Pro Val Leu Tyr His Asn Ser Arg Ala Arg Ser Thr
        595                 600                 605             
Gly Ala Cys Asn Cys Gly Arg Lys Gln Ala Pro Arg Asp Asp Pro Phe
    610                 615                 620                 
Asp Ile Lys Ala Ala Asn Tyr Asp Phe Tyr Gln Leu Leu Glu Glu Lys
625                 630                 635                 640 
Cys Cys Gly Lys Leu Asp His Ile Asn Phe Pro Val Phe Glu Pro Ser
                645                 650                 655     
Thr Pro Asp Pro Ala Pro Ala Lys Asn Glu Ser Ser Pro Ala Pro Pro
            660                 665                 670         
Asp Ser Asp Ala Asp Lys Leu Lys Glu Lys Glu Pro Gln Thr Gln Gly
        675                 680                 685             
Glu Ser Thr Ser Leu Ser Leu Ala Leu Ser Leu Gly Gln Ser Thr Asp
    690                 695                 700                 
Ser Leu Gly Thr Tyr Pro Ala Asp Pro Gln Ala Gly Gly Asp Asn Pro
705                 710                 715                 720 
Glu Val His Gly Gln Val Glu Val Lys Thr Glu Lys Arg Pro Asn Phe
                725                 730                 735     
Val Asp Arg Gln Ala Ser Thr Val Glu Tyr Leu Pro Gly Met Leu His
            740                 745                 750         
Ser Asn Cys Pro Lys Gly Leu Leu Pro Lys Phe Ser Ser Trp Ser Leu
        755                 760                 765             
Val Lys Leu Gly Pro Ala Lys Ser Tyr Asn Phe His Thr Gly Leu Asp
    770                 775                 780                 
Gln Gln Gly Phe Ile Pro Gly Thr Asn Tyr Leu Met Pro Trp Asp Ile
785                 790                 795                 800 
Val Ile Arg Thr Arg Ala Glu Asp Glu Gly Asp Leu Asp Thr Asn Ser
                805                 810                 815     
Trp Pro Ala Pro Asn Lys Ala Ile Pro Gly Lys Arg Ser Ala Val Val
            820                 825                 830         
Met Gly Arg Gly Arg Arg Arg Asp Asp Ile Ala Arg Ala Phe Val Gly
        835                 840                 845             
Phe Glu Tyr Glu Asp Ser Arg Gly Arg Arg Phe Met Cys Ser Gly Pro
    850                 855                 860                 
Asp Lys Val Met Lys Val Met Gly Ser Gly Pro Lys Glu Ser Ala Leu
865                 870                 875                 880 
Lys Ala Leu Asn Ser Asp Met Pro Leu Tyr Ile Leu Ser Ser Ser Gln
                885                 890                 895     
Gly Arg Gly Leu Lys Pro His Tyr Ala Gln Leu Met Arg Leu Phe Val
            900                 905                 910         
Val Val Pro Asp Ala Pro Leu Gln Ile Ile Leu Met Pro Gln Val Gln
        915                 920                 925             
Pro Gly Pro Pro Pro Cys Pro Val Phe Tyr Pro Glu Lys Gln Glu Ile
    930                 935                 940                 
Thr Leu Pro Pro Asp Gly Leu Trp Val Leu Arg Phe Pro Tyr Ala Tyr
945                 950                 955                 960 
Val Thr Glu Arg Gly Pro Cys Phe Pro Pro Lys Glu Asn Val Gln Leu
                965                 970                 975     
Met Ser Tyr Lys Val Leu Arg Gly Val Leu Lys Ala Val Thr Gln
            980                 985                 990     


<210> 7507
<211> 478
<212> PRT
<213> Homo sapiens

<400> 7507
Met Lys Met Ser Ile Arg Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly
 1               5                  10                  15      
Arg Ser Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu
            20                  25                  30          
Leu Pro Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg
        35                  40                  45              
Arg Arg Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Arg
    50                  55                  60                  
Arg Leu Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe
65                  70                  75                  80  
Gln Ala Val Leu Asp Gly Leu Asp Ala Leu Leu Thr Gln Gly Val Arg
                85                  90                  95      
Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu
            100                 105                 110         
Asn Phe Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu
        115                 120                 125             
Asn Ala Lys Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg
    130                 135                 140                 
Gly Arg Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg
145                 150                 155                 160 
Thr Leu Asp Glu Tyr Leu Thr Tyr Leu Leu Leu Trp Val Lys Gln Arg
                165                 170                 175     
Lys Asp Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met
            180                 185                 190         
Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys
        195                 200                 205             
Ile Gln Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr
    210                 215                 220                 
Gln Phe Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val
225                 230                 235                 240 
Leu Ser His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys
                245                 250                 255     
Glu Ile Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Arg Cys Leu
            260                 265                 270         
Gln Lys Leu Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp
        275                 280                 285             
Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr
    290                 295                 300                 
Asn Cys Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro
305                 310                 315                 320 
Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr
                325                 330                 335     
Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala
            340                 345                 350         
Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln
        355                 360                 365             
Val Asn Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr
    370                 375                 380                 
Phe Ser Phe Cys Gly Asn Pro Ile Cys Met Ala Thr Leu Glu Asn Leu
385                 390                 395                 400 
Leu Ser His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro
                405                 410                 415     
Ala Pro Arg Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg
            420                 425                 430         
Phe Ala Gln Ile Arg Ala Glu Leu Met Asn Arg Val Arg Asp Leu Arg
        435                 440                 445             
His Pro Lys Arg Ile Leu Phe Cys Thr Asp Tyr Cys Pro Asp Cys Gly
    450                 455                 460                 
Asn Arg Ser Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys
465                 470                 475             


<210> 7508
<211> 500
<212> PRT
<213> Homo sapiens

<400> 7508
Pro Ala Trp Phe Phe Leu Arg Ser Glu His Leu Leu Asp Tyr Ile Gln
 1               5                  10                  15      
Ile Cys Phe Pro Cys Arg Phe Met Lys Met Ser Ile Trp Thr Pro Pro
            20                  25                  30          
Arg Leu Leu Glu Leu Ala Gly Arg Ser Leu Leu Arg Asp Gln Ala Leu
        35                  40                  45              
Ala Met Ser Thr Leu Glu Glu Leu Pro Thr Glu Leu Phe Pro Pro Leu
    50                  55                  60                  
Phe Met Glu Ala Phe Ser Arg Arg Arg Cys Glu Ala Leu Lys Leu Met
65                  70                  75                  80  
Val Gln Ser Trp Pro Phe Arg Arg Leu Pro Leu Arg Pro Leu Ile Lys
                85                  90                  95      
Met Pro Cys Leu Glu Ala Phe Gln Ala Val Leu Asp Gly Leu Asp Ala
            100                 105                 110         
Leu Leu Asn Leu Gly Val Arg Pro Arg Arg Trp Lys Leu Gln Val Leu
        115                 120                 125             
Asp Leu Gln Asp Val Cys Glu Asn Phe Trp Met Val Trp Ser Glu Ala
    130                 135                 140                 
Met Ala His Gly Cys Phe Leu Asn Ala Lys Arg Asn Lys Lys Pro Val
145                 150                 155                 160 
Glu Asp Cys Pro Arg Met Arg Gly Arg Gln Pro Leu Thr Val Phe Val
                165                 170                 175     
Glu Leu Trp Leu Lys Asn Arg Thr Leu Asp Glu Tyr Leu Thr Cys Leu
            180                 185                 190         
Leu Leu Trp Val Lys Gln Arg Lys Asp Leu Leu His Leu Cys Cys Lys
        195                 200                 205             
Lys Leu Lys Ile Leu Gly Met Pro Phe Arg Asn Ile Arg Ser Ile Leu
    210                 215                 220                 
Lys Met Val Asn Leu Asp Cys Ile Gln Glu Val Glu Val Asn Cys Lys
225                 230                 235                 240 
Trp Val Leu Pro Ile Leu Thr Gln Phe Thr Pro Tyr Leu Gly His Met
                245                 250                 255     
Arg Asn Leu Gln Lys Leu Ile Leu Ser His Met Asp Val Ser Arg Tyr
            260                 265                 270         
Val Ser Pro Glu Gln Lys Lys Glu Ile Val Thr Gln Phe Thr Thr Gln
        275                 280                 285             
Phe Leu Lys Leu Arg Cys Leu Gln Lys Leu Tyr Met Asn Ser Val Ser
    290                 295                 300                 
Phe Leu Glu Gly His Leu Asp Gln Leu Leu Ser Cys Leu Lys Thr Ser
305                 310                 315                 320 
Leu Lys Phe Leu Thr Ile Thr Asn Cys Val Leu Leu Glu Ser Asp Leu
                325                 330                 335     
Lys His Leu Ser Gln Cys Pro Ser Ile Ser Gln Leu Lys Thr Leu Asp
            340                 345                 350         
Leu Ser Gly Ile Arg Leu Thr Asn Tyr Ser Leu Val Pro Leu Gln Ile
        355                 360                 365             
Leu Leu Glu Lys Val Ala Ala Thr Leu Glu Tyr Leu Asp Leu Asp Asp
    370                 375                 380                 
Cys Gly Ile Ile Asp Ser Gln Val Asn Ala Ile Leu Pro Ala Leu Ser
385                 390                 395                 400 
Arg Cys Phe Glu Leu Asn Thr Phe Ser Phe Cys Gly Asn Pro Ile Cys
                405                 410                 415     
Met Ala Thr Leu Glu Asn Leu Leu Ser His Thr Ile Ile Leu Lys Asn
            420                 425                 430         
Leu Cys Val Glu Leu Tyr Pro Ala Pro Arg Glu Ser Tyr Gly Ala Asp
        435                 440                 445             
Gly Thr Leu Cys Trp Ser Arg Phe Ala Gln Ile Arg Ala Glu Leu Met
    450                 455                 460                 
Asn Arg Val Arg Asp Leu Arg His Pro Lys Arg Ile Leu Phe Cys Thr
465                 470                 475                 480 
Asp Tyr Cys Pro Asp Cys Gly Asn Arg Ser Phe Tyr Asp Leu Glu Ala
                485                 490                 495     
Asp Gln Tyr Cys
            500 


<210> 7509
<211> 434
<212> PRT
<213> Homo sapiens

<400> 7509
Met Glu Leu Ser Glu Arg Tyr Gly Pro Val Phe Thr Val His Leu Gly
 1               5                  10                  15      
Arg Gln Lys Thr Val Val Leu Thr Gly Phe Glu Ala Val Lys Glu Ala
            20                  25                  30          
Leu Ala Gly Pro Gly Gln Glu Leu Ala Asp Arg Pro Pro Ile Ala Ile
        35                  40                  45              
Phe Gln Leu Ile Gln Arg Gly Gly Gly Ile Phe Phe Ser Ser Gly Ala
    50                  55                  60                  
Arg Trp Arg Ala Ala Arg Gln Phe Thr Val Arg Ala Leu His Ser Leu
65                  70                  75                  80  
Gly Val Gly Arg Glu Pro Val Ala Asp Lys Ile Leu Gln Glu Leu Lys
                85                  90                  95      
Cys Leu Ser Gly Gln Leu Asp Gly Tyr Arg Gly Arg Pro Phe Pro Leu
            100                 105                 110         
Ala Leu Leu Gly Trp Ala Pro Ser Asn Ile Thr Phe Ala Leu Leu Phe
        115                 120                 125             
Gly Arg Arg Phe Asp Tyr Arg Asp Pro Val Phe Val Ser Leu Leu Gly
    130                 135                 140                 
Leu Ile Asp Glu Val Met Val Leu Leu Gly Ser Pro Gly Leu Gln Leu
145                 150                 155                 160 
Phe Asn Val Tyr Pro Trp Leu Gly Ala Leu Leu Gln Leu His Arg Pro
                165                 170                 175     
Val Leu Arg Lys Ile Glu Glu Val Arg Ala Ile Leu Arg Thr Leu Leu
            180                 185                 190         
Glu Ala Arg Arg Pro His Val Cys Pro Gly Asp Pro Val Cys Ser Tyr
        195                 200                 205             
Val Asp Ala Leu Ile Gln Gln Gly Gln Gly Asp Asp Pro Glu Gly Leu
    210                 215                 220                 
Phe Ala Glu Ala Asn Ala Val Ala Cys Thr Leu Asp Met Val Met Ala
225                 230                 235                 240 
Gly Thr Glu Thr Thr Ser Ala Thr Leu Gln Trp Ala Ala Leu Leu Met
                245                 250                 255     
Gly Arg His Pro Asp Val Gln Gly Arg Val Gln Glu Glu Leu Asp Arg
            260                 265                 270         
Val Leu Gly Pro Gly Arg Thr Pro Arg Leu Glu Asp Gln Gln Ala Leu
        275                 280                 285             
Pro Tyr Thr Ser Ala Val Leu His Glu Val Gln Arg Phe Ile Thr Leu
    290                 295                 300                 
Leu Pro His Val Pro Arg Cys Thr Ala Ala Asp Thr Gln Leu Gly Gly
305                 310                 315                 320 
Phe Leu Leu Pro Lys Gly Thr Pro Val Ile Pro Leu Leu Thr Ser Val
                325                 330                 335     
Leu Leu Asp Glu Thr Gln Trp Gln Thr Pro Gly Gln Phe Asn Pro Gly
            340                 345                 350         
His Phe Leu Asp Ala Asn Gly His Phe Val Lys Arg Glu Ala Phe Leu
        355                 360                 365             
Pro Phe Ser Ala Gly Arg Arg Val Cys Val Gly Glu Arg Leu Ala Arg
    370                 375                 380                 
Thr Glu Leu Phe Leu Leu Phe Ala Gly Leu Leu Gln Arg Tyr Arg Leu
385                 390                 395                 400 
Leu Pro Pro Pro Gly Val Ser Pro Ala Ser Leu Asp Thr Thr Pro Ala
                405                 410                 415     
Arg Ala Phe Thr Met Arg Pro Arg Ala Gln Ala Leu Cys Ala Val Pro
            420                 425                 430         
Arg Pro
        


<210> 7510
<211> 638
<212> PRT
<213> Homo sapiens

<400> 7510
Met Ala Gly Ser Ile Ser Val Glu Ile Ser Lys Ile Ser Ala Trp Lys
 1               5                  10                  15      
Asn Pro Asp Ala Asp Phe Glu Arg Phe Ser Arg Ala Ala Ala Arg Gly
            20                  25                  30          
Arg Pro Ala Leu Pro Asn Pro Glu Gly Arg Ala Arg Glu Pro Cys Pro
        35                  40                  45              
Asn Arg Thr Ala Ala Ser Trp Gly Phe His Cys Glu Asp Gly Ala Ser
    50                  55                  60                  
Ser Pro Gln His Pro Pro Arg Arg Gly Arg Ser Phe Gly Thr Pro Gly
65                  70                  75                  80  
Asp Thr Trp Gly Arg Val His Cys Glu Asp Arg Glu Thr Leu Arg Asp
                85                  90                  95      
Thr Trp Gly Arg Arg Gly Glu Ser Glu Lys Lys Ala Phe Cys Pro Arg
            100                 105                 110         
Ser Pro Thr Pro Glu Gly Pro Gly Leu Gly Thr Pro Gly Asp Thr Trp
        115                 120                 125             
Gly Arg Val Arg Cys Glu Asp Arg Glu Thr Leu Leu Gln Leu Arg Asp
    130                 135                 140                 
Thr Trp Gly Arg Arg Gly Lys Ala Gln Gly Gln Asp Ala Gly Tyr Glu
145                 150                 155                 160 
Cys Glu Phe Val Ser Gly Glu Arg Pro Trp Tyr Arg Glu Arg Arg Arg
                165                 170                 175     
Asn Ala Glu Thr Pro Ser Gly Gly Gly Asp Val Gly Asp Trp Gln Ala
            180                 185                 190         
Pro Gln Pro Glu Phe Trp Glu Val Ile Ser Asp Glu His Ala Ile Asp
        195                 200                 205             
Ser Ala Gly Thr Tyr His Gly Asp Ser His Leu Gln Leu Glu Arg Ile
    210                 215                 220                 
Asn Val His His His Glu Ala Ser Gly Ala Thr Pro Val Leu Pro Pro
225                 230                 235                 240 
Pro Asn Val His His His Glu Ala Ser Gly Gly Arg Tyr Val Pro Arg
                245                 250                 255     
Ala Val Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser
            260                 265                 270         
Gly Pro Phe Gly Gln Val Leu Arg Pro Asp Asn Phe Ile Phe Gly Gln
        275                 280                 285             
Cys Gly Ala Gly Asn Asn Trp Ala Lys Gly Arg Tyr Thr Glu Gly Ala
    290                 295                 300                 
Glu Leu Thr Glu Ser Val Met Asp Val Val Arg Lys Glu Ala Glu Ser
305                 310                 315                 320 
Cys Asp Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly
                325                 330                 335     
Thr Gly Ser Gly Met Val Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu
            340                 345                 350         
Tyr Pro Asp Arg Ile Ile Asn Thr Phe Ser Ile Leu Pro Ser Pro Lys
        355                 360                 365             
Val Ser Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His
    370                 375                 380                 
Gln Leu Ile Glu Asn Ala Asp Glu Thr Phe Cys Ile Asp Asn Glu Ala
385                 390                 395                 400 
Leu Tyr Asp Ile Cys Ser Lys Thr Leu Lys Leu Pro Thr Pro Thr Tyr
                405                 410                 415     
Gly Asp Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr
            420                 425                 430         
Cys Leu Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala
        435                 440                 445             
Val Asn Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe
    450                 455                 460                 
Ala Pro Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val
465                 470                 475                 480 
Ala Glu Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Arg Ala Ala
                485                 490                 495     
Arg Asp Pro Arg His Gly Arg Tyr Leu Thr Ala Ala Ala Ile Phe Gln
            500                 505                 510         
Gly Arg Met Pro Met Arg Glu Val Asp Glu Gln Met Phe Asn Ile Gln
        515                 520                 525             
Asp Lys Asn Ser Ser Tyr Phe Ala Asp Trp Phe Pro Asp Asn Val Lys
    530                 535                 540                 
Thr Ala Ile Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Ser
545                 550                 555                 560 
Phe Ile Gly Asn Asn Ala Ala Ile Gln Glu Leu Phe Thr Cys Val Ser
                565                 570                 575     
Glu Gln Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr
            580                 585                 590         
Thr Gly Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn
        595                 600                 605             
Met Asn Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala
    610                 615                 620                 
Lys Glu Glu Glu Asp Glu Glu Tyr Ala Glu Glu Glu Val Ala
625                 630                 635             


<210> 7511
<211> 217
<212> PRT
<213> Homo sapiens

<400> 7511
Met Ala Gly Arg Thr Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp
 1               5                  10                  15      
Asp Ile Lys Lys Val Met Ala Thr Ile Glu Lys Val Arg Arg Trp Glu
            20                  25                  30          
Lys Arg Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp
        35                  40                  45              
Val Pro Val Val Asp Pro Gln Glu Glu Glu Arg Arg Arg Ala Gly Gly
    50                  55                  60                  
Gly Ala Glu Arg Ser Arg Gly Arg Glu Arg Arg Gly Arg Gly Ala Ser
65                  70                  75                  80  
Pro Arg Gly Gly Gly Pro Leu Ile Leu Leu Asp Leu Asn Asp Glu Asn
                85                  90                  95      
Ser Asn Gln Ser Phe His Ser Glu Gly Ser Leu Pro Lys Gly Thr Glu
            100                 105                 110         
Pro Ser Pro Gly Gly Thr Pro Gln Pro Ser Arg Pro Val Ser Pro Ala
        115                 120                 125             
Gly Pro Pro Glu Gly Val Pro Glu Glu Ala Gln Pro Pro Arg Leu Gly
    130                 135                 140                 
Gln Glu Arg Asp Pro Gly Gly Ile Thr Ala Gly Ser Thr Asp Glu Pro
145                 150                 155                 160 
Pro Met Leu Thr Lys Glu Glu Pro Val Pro Glu Leu Leu Glu Ala Glu
                165                 170                 175     
Ala Pro Glu Ala Tyr Pro Val Phe Glu Pro Val Pro Pro Val Pro Glu
            180                 185                 190         
Ala Ala Gln Gly Asp Thr Glu Asp Ser Gly Gly Ala Pro Pro Leu Lys
        195                 200                 205             
Arg Ile Cys Pro Asn Ala Pro Asp Pro
    210                 215         


<210> 7512
<211> 607
<212> PRT
<213> Homo sapiens

<400> 7512
Met Ala Phe Arg Arg Gln Val Lys Asn Phe Val Lys Asn Tyr Ser Asp
 1               5                  10                  15      
Ala Glu Ile Lys Val Arg Glu Ala Thr Ser Asn Asp Pro Trp Gly Pro
            20                  25                  30          
Ser Ser Ser Leu Met Leu Asp Ile Ser Asp Leu Thr Phe Asn Thr Ile
        35                  40                  45              
Ser Leu Ser Glu Ile Met Asn Met Leu Trp His Arg Leu Asn Asp His
    50                  55                  60                  
Gly Lys Asn Trp Arg His Val Tyr Lys Ser Leu Thr Leu Met Asp Tyr
65                  70                  75                  80  
Leu Ile Lys Asn Gly Ser Lys Lys Val Ile Gln His Cys Arg Glu Gly
                85                  90                  95      
Phe Cys Asn Leu Gln Thr Leu Lys Asp Phe Gln His Ile Asp Glu Ala
            100                 105                 110         
Gly Lys Asp Gln Gly Tyr Tyr Ile Arg Glu Lys Ser Lys Gln Val Ile
        115                 120                 125             
Thr Leu Leu Met Asp Glu Pro Leu Leu Cys Lys Glu Arg Glu Val Ala
    130                 135                 140                 
Cys Arg Thr Arg Gln Arg Thr Ser His Ser Ile Leu Phe Ser Lys Arg
145                 150                 155                 160 
Gln Leu Gly Ser Ser Asn Ser Leu Thr Ala Cys Thr Ser Ala Pro Thr
                165                 170                 175     
Pro Asp Ile Ser Ala Ser Glu Lys Lys Tyr Lys Leu Pro Lys Phe Gly
            180                 185                 190         
Arg Leu His Asn Lys Arg Asn Val Cys Lys Ala Gly Leu Lys Gln Glu
        195                 200                 205             
His Cys Gln Asp Val His Leu Pro Thr Glu Thr Met Leu Ser Gln Glu
    210                 215                 220                 
Thr Leu Pro Leu Lys Ile His Gly Trp Lys Ser Thr Glu Asp Leu Met
225                 230                 235                 240 
Thr Phe Leu Asp Asp Asp Pro Glu Leu Pro Leu Leu Ala Thr Pro Pro
                245                 250                 255     
Ser Ile Val Ser Pro Ile Thr Cys Leu Ser Glu Ala Glu Glu Val Cys
            260                 265                 270         
Asn Leu Ser Gly Ala Asp Ala Val Pro Thr Leu Ser Glu Asn Ser Pro
        275                 280                 285             
Ser Gly Gln Arg Asp Val Ser Leu Asp Lys Arg Ser Asp Gly Ile Phe
    290                 295                 300                 
Thr Asn Thr Val Thr Glu Asn Leu Leu Glu Thr Pro Leu Glu Lys Gln
305                 310                 315                 320 
Ser Ala Ala Glu Gly Leu Lys Thr Leu Thr Ile Leu Pro Ala Cys Trp
                325                 330                 335     
Ser Ser Lys Glu Glu Phe Ile Ser Pro Asp Leu Arg Val Ser Lys Ser
            340                 345                 350         
Asp Ser Thr Phe His Asn Gln Ala Ser Val Glu Thr Leu Cys Leu Ser
        355                 360                 365             
Pro Ser Phe Lys Ile Phe Asp Arg Val Lys Glu Ile Val Ile Asn Lys
    370                 375                 380                 
Ala Tyr Gln Lys Pro Ala Gln Ser Ser Ile Gln Met Asp Asp Lys Ile
385                 390                 395                 400 
Leu Lys Thr Thr Thr Arg Val Ser Thr Ala Ser Glu Gly Ala Ser Ser
                405                 410                 415     
Phe Ser Pro Leu Ser Met Ser Ser Pro Asp Leu Ala Ser Pro Glu Lys
            420                 425                 430         
Ser Ala His Leu Leu Ser Pro Ile Leu Ala Gly Pro Ser Phe Trp Thr
        435                 440                 445             
Leu Ser His Gln Gln Leu Ser Ser Thr Ser Phe Lys Asp Glu Asp Lys
    450                 455                 460                 
Thr Ala Lys Leu His His Ser Phe Ala Ser Arg Gly Pro Val Ser Ser
465                 470                 475                 480 
Asp Val Glu Glu Asn Asp Ser Leu Asn Leu Leu Gly Ile Leu Pro Asn
                485                 490                 495     
Asn Ser Asp Ser Ala Lys Lys Asn Ile Ser His Ile Ser Ser Ser His
            500                 505                 510         
Trp Gly Glu Phe Ser Thr Gln Asn Val Asp Gln Phe Ile Pro Leu Ser
        515                 520                 525             
Cys Ser Gly Phe Gln Ser Thr Lys Asp Phe Pro Gln Glu Pro Glu Ala
    530                 535                 540                 
Lys Asn Ser Ile Ser Val Leu Leu Arg Glu Val Lys Arg Ala Ile Ala
545                 550                 555                 560 
Arg Leu His Glu Asp Leu Ser Thr Val Ile Gln Glu Leu Asn Val Ile
                565                 570                 575     
Asn Asn Ile Leu Met Ser Met Ser Leu Asn Ser Ser Gln Ile Ser Gln
            580                 585                 590         
Ser Ser Gln Val Pro Gln Ser Ser Glu Gly Ser Ser Asp Gln Ile
        595                 600                 605         


<210> 7513
<211> 329
<212> PRT
<213> Homo sapiens

<400> 7513
Met Ala Asp Gly Gly Ser Pro Phe Leu Gly Arg Arg Asp Phe Val Tyr
 1               5                  10                  15      
Pro Ser Ser Thr Arg Asp Pro Ser Ala Ser Asn Gly Gly Gly Ser Pro
            20                  25                  30          
Ala Arg Arg Glu Glu Lys Lys Arg Lys Ala Ala Arg Leu Lys Phe Asp
        35                  40                  45              
Phe Gln Ala Gln Ser Pro Lys Glu Leu Thr Leu Gln Lys Gly Asp Ile
    50                  55                  60                  
Val Tyr Ile His Lys Glu Val Asp Lys Asn Trp Leu Glu Gly Glu His
65                  70                  75                  80  
His Gly Arg Leu Gly Ile Phe Pro Ala Asn Tyr Val Glu Val Leu Pro
                85                  90                  95      
Ala Asp Glu Ile Pro Lys Pro Ile Lys Pro Pro Thr Tyr Gln Val Leu
            100                 105                 110         
Glu Tyr Gly Glu Ala Val Ala Gln Tyr Thr Phe Lys Gly Asp Leu Glu
        115                 120                 125             
Val Glu Leu Ser Phe Arg Lys Gly Glu His Ile Cys Leu Ile Arg Lys
    130                 135                 140                 
Val Asn Glu Asn Trp Tyr Glu Gly Arg Ile Thr Gly Thr Gly Arg Gln
145                 150                 155                 160 
Gly Ile Phe Pro Ala Ser Tyr Val Gln Val Ser Arg Glu Pro Arg Leu
                165                 170                 175     
Arg Leu Cys Asp Asp Gly Pro Gln Leu Pro Thr Ser Pro Arg Leu Thr
            180                 185                 190         
Ala Ala Ala Arg Ser Ala Arg His Pro Ser Ser Pro Ser Ala Leu Arg
        195                 200                 205             
Ser Pro Ala Asp Pro Thr Asp Leu Gly Gly Gln Thr Ser Pro Arg Arg
    210                 215                 220                 
Thr Gly Phe Ser Phe Pro Thr Gln Glu Pro Arg Pro Gln Thr Gln Asn
225                 230                 235                 240 
Leu Gly Thr Pro Gly Pro Ala Leu Ser His Ser Arg Gly Pro Ser His
                245                 250                 255     
Pro Leu Asp Leu Gly Thr Ser Ser Pro Asn Thr Ser Gln Ile His Trp
            260                 265                 270         
Thr Pro Tyr Arg Ala Met Tyr Gln Tyr Arg Pro Gln Asn Glu Asp Glu
        275                 280                 285             
Leu Glu Leu Arg Glu Gly Asp Arg Val Asp Val Met Gln Gln Cys Asp
    290                 295                 300                 
Asp Gly Trp Phe Val Gly Val Ser Arg Arg Thr Gln Lys Phe Gly Thr
305                 310                 315                 320 
Phe Pro Gly Asn Tyr Val Ala Pro Val
                325                 


<210> 7514
<211> 671
<212> PRT
<213> Homo sapiens

<400> 7514
Met Gln Gly Pro Pro Arg Ser Leu Arg Ala Gly Leu Ser Leu Asp Asp
 1               5                  10                  15      
Phe Ile Pro Gly His Leu Gln Ser His Ile Gly Ser Ser Ser Arg Gly
            20                  25                  30          
Thr Arg Val Pro Val Ile Arg Asn Gly Gly Ser Asn Thr Leu Asn Phe
        35                  40                  45              
Gln Phe His Asp Pro Ala Pro Arg Thr Val Cys Asn Gly Gly Tyr Thr
    50                  55                  60                  
Pro Arg Arg Asp Ala Ser Gln His Pro Asp Pro Ala Trp Tyr Gln Thr
65                  70                  75                  80  
Trp Pro Gly Pro Gly Ser Lys Pro Ser Ala Ser Thr Lys Ile Pro Ala
                85                  90                  95      
Ser Gln His Thr Gln Asn Trp Ser Ala Thr Trp Thr Lys Asp Ser Lys
            100                 105                 110         
Arg Arg Asp Lys Arg Trp Val Lys Tyr Glu Gly Ile Gly Pro Val Asp
        115                 120                 125             
Glu Ser Gly Met Pro Ile Ala Pro Arg Ser Ser Val Asp Arg Pro Arg
    130                 135                 140                 
Asp Trp Tyr Arg Arg Met Phe Gln Gln Ile His Arg Lys Met Pro Asp
145                 150                 155                 160 
Leu Gln Leu Asp Trp Thr Phe Glu Glu Pro Pro Arg Asp Pro Arg His
                165                 170                 175     
Leu Gly Ala Gln Gln Arg Pro Ala His Arg Pro Gly Pro Ala Thr Ser
            180                 185                 190         
Ser Ser Gly Arg Ser Trp Asp His Ser Glu Glu Leu Pro Arg Ser Thr
        195                 200                 205             
Phe Asn Tyr Arg Pro Gly Ala Phe Ser Thr Val Leu Gln Pro Ser Asn
    210                 215                 220                 
Gln Val Leu Arg Arg Arg Glu Lys Val Asp Asn Val Trp Thr Glu Glu
225                 230                 235                 240 
Ser Trp Asn Gln Phe Leu Gln Glu Leu Glu Thr Gly Gln Arg Pro Lys
                245                 250                 255     
Lys Pro Leu Val Asp Asp Pro Gly Glu Lys Pro Ser Gln Pro Ile Glu
            260                 265                 270         
Val Leu Leu Glu Arg Glu Leu Ala Glu Leu Ser Ala Glu Leu Asp Lys
        275                 280                 285             
Asp Leu Arg Ala Ile Glu Thr Arg Leu Pro Ser Pro Lys Ser Ser Pro
    290                 295                 300                 
Ala Pro Arg Arg Ala Pro Glu Gln Arg Pro Pro Ala Gly Pro Ala Ser
305                 310                 315                 320 
Ala Trp Ser Ser Ser Tyr Pro His Ala Pro Tyr Leu Gly Ser Ala Arg
                325                 330                 335     
Ser Leu Ser Pro His Lys Met Ala Asp Gly Gly Ser Pro Phe Leu Gly
            340                 345                 350         
Arg Arg Asp Phe Val Tyr Pro Ser Ser Thr Arg Asp Pro Ser Ala Ser
        355                 360                 365             
Asn Gly Gly Gly Ser Pro Ala Arg Arg Glu Glu Lys Lys Arg Lys Ala
    370                 375                 380                 
Ala Arg Leu Lys Phe Asp Phe Gln Ala Gln Ser Pro Lys Glu Leu Thr
385                 390                 395                 400 
Leu Gln Lys Gly Asp Ile Val Tyr Ile His Lys Glu Val Asp Lys Asn
                405                 410                 415     
Trp Leu Glu Gly Glu His His Gly Arg Leu Gly Ile Phe Pro Ala Asn
            420                 425                 430         
Tyr Val Glu Val Leu Pro Ala Asp Glu Ile Pro Lys Pro Ile Lys Pro
        435                 440                 445             
Pro Thr Tyr Gln Val Leu Glu Tyr Gly Glu Ala Val Ala Gln Tyr Thr
    450                 455                 460                 
Phe Lys Gly Asp Leu Glu Val Glu Leu Ser Phe Arg Lys Gly Glu His
465                 470                 475                 480 
Ile Cys Leu Ile Arg Lys Val Asn Glu Asn Trp Tyr Glu Gly Arg Ile
                485                 490                 495     
Thr Gly Thr Gly Arg Gln Gly Ile Phe Pro Ala Ser Tyr Val Gln Val
            500                 505                 510         
Ser Arg Glu Pro Arg Leu Arg Leu Cys Asp Asp Gly Pro Gln Leu Pro
        515                 520                 525             
Thr Ser Pro Arg Leu Thr Ala Ala Ala Arg Ser Ala Arg His Pro Ser
    530                 535                 540                 
Ser Pro Ser Ala Leu Arg Ser Pro Ala Asp Pro Thr Asp Leu Gly Gly
545                 550                 555                 560 
Gln Thr Ser Pro Arg Arg Thr Gly Phe Ser Phe Pro Thr Gln Glu Pro
                565                 570                 575     
Arg Pro Gln Thr Gln Asn Leu Gly Thr Pro Gly Pro Ala Leu Ser His
            580                 585                 590         
Ser Arg Gly Pro Ser His Pro Leu Asp Leu Gly Thr Ser Ser Pro Asn
        595                 600                 605             
Thr Ser Gln Ile His Trp Thr Pro Tyr Arg Ala Met Tyr Gln Tyr Arg
    610                 615                 620                 
Pro Gln Asn Glu Asp Glu Leu Glu Leu Arg Glu Gly Asp Arg Val Asp
625                 630                 635                 640 
Val Met Gln Gln Cys Asp Asp Gly Trp Phe Val Gly Val Ser Arg Arg
                645                 650                 655     
Thr Gln Lys Phe Gly Thr Phe Pro Gly Asn Tyr Val Ala Pro Val
            660                 665                 670     


<210> 7515
<211> 390
<212> PRT
<213> Homo sapiens

<400> 7515
Met Val Glu Ala Asp Arg Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn
 1               5                  10                  15      
Thr Glu Thr Asn Glu Lys Ala Leu Glu Thr Val Phe Gly Lys Tyr Gly
            20                  25                  30          
Arg Ile Val Glu Val Leu Leu Ile Lys Asp Arg Glu Thr Asn Lys Ser
        35                  40                  45              
Arg Gly Phe Ala Phe Val Thr Phe Glu Ser Pro Ala Asp Ala Lys Asp
    50                  55                  60                  
Ala Ala Arg Asp Met Asn Gly Lys Ser Leu Asp Gly Lys Ala Ile Lys
65                  70                  75                  80  
Val Glu Gln Ala Thr Lys Pro Ser Phe Glu Arg Gly Arg His Gly Pro
                85                  90                  95      
Pro Pro Pro Pro Arg Ser Arg Gly Pro Pro Arg Gly Phe Gly Ala Gly
            100                 105                 110         
Arg Gly Gly Ser Gly Gly Thr Arg Gly Pro Pro Ser Arg Gly Gly His
        115                 120                 125             
Met Asp Asp Gly Gly Tyr Ser Met Asn Phe Asn Met Ser Ser Ser Arg
    130                 135                 140                 
Gly Pro Leu Pro Val Lys Arg Gly Pro Pro Pro Arg Ser Gly Gly Pro
145                 150                 155                 160 
Ser Pro Lys Arg Ser Ala Pro Ser Gly Leu Val Arg Ser Ser Ser Gly
                165                 170                 175     
Met Gly Gly Arg Ala Pro Leu Ser Arg Gly Arg Asp Ser Tyr Gly Gly
            180                 185                 190         
Pro Pro Arg Arg Glu Pro Leu Pro Ser Arg Arg Asp Val Tyr Leu Ser
        195                 200                 205             
Pro Arg Asp Asp Gly Tyr Ser Thr Lys Asp Ser Tyr Ser Ser Arg Asp
    210                 215                 220                 
Tyr Pro Ser Ser Arg Asp Thr Arg Asp Tyr Ala Pro Pro Pro Arg Asp
225                 230                 235                 240 
Tyr Thr Tyr Arg Asp Tyr Gly His Ser Ser Ser Arg Asp Asp Tyr Pro
                245                 250                 255     
Ser Arg Gly Tyr Gly Asp Arg Asp Gly Tyr Gly Arg Asp Arg Asp Tyr
            260                 265                 270         
Ser Asp His Pro Ser Gly Gly Ser Tyr Arg Asp Ser Tyr Glu Ser Tyr
        275                 280                 285             
Gly Asn Ser Arg Ser Ala Pro Leu Thr Arg Gly Pro Pro Pro Ser Tyr
    290                 295                 300                 
Gly Gly Ser Ser Arg Tyr Asp Asp Tyr Ser Ser Ser Arg Asp Gly Tyr
305                 310                 315                 320 
Gly Gly Ser Arg Asp Ser Tyr Ser Ser Ser Arg Ser Asp Leu Tyr Ser
                325                 330                 335     
Ser Cys Asp Arg Val Gly Arg Gln Glu Arg Gly Leu Pro Pro Ser Val
            340                 345                 350         
Glu Arg Gly Tyr Pro Ser Ser Arg Asp Ser Tyr Ser Ser Ser Ser Arg
        355                 360                 365             
Gly Ala Pro Arg Gly Ala Gly Pro Gly Gly Ser Arg Ser Asp Arg Gly
    370                 375                 380                 
Gly Gly Arg Ser Arg Tyr
385                 390 


<210> 7516
<211> 391
<212> PRT
<213> Homo sapiens

<400> 7516
Met Val Glu Ala Asp Arg Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn
 1               5                  10                  15      
Thr Glu Thr Asn Glu Lys Ala Leu Glu Ala Val Phe Gly Lys Tyr Gly
            20                  25                  30          
Arg Ile Val Glu Val Leu Leu Met Lys Asp Arg Glu Thr Asn Lys Ser
        35                  40                  45              
Arg Gly Phe Ala Phe Val Thr Phe Glu Ser Pro Ala Asp Ala Lys Asp
    50                  55                  60                  
Ala Ala Arg Asp Met Asn Gly Lys Ser Leu Asp Gly Lys Ala Ile Lys
65                  70                  75                  80  
Val Glu Gln Ala Thr Lys Pro Ser Phe Glu Ser Gly Arg Arg Gly Pro
                85                  90                  95      
Pro Pro Pro Pro Arg Ser Arg Gly Pro Pro Arg Gly Leu Arg Gly Gly
            100                 105                 110         
Arg Gly Gly Ser Gly Gly Thr Arg Gly Pro Pro Ser Arg Gly Gly His
        115                 120                 125             
Met Asp Asp Gly Gly Tyr Ser Met Asn Phe Asn Met Ser Ser Ser Arg
    130                 135                 140                 
Gly Pro Leu Pro Val Lys Arg Gly Pro Pro Pro Arg Ser Gly Gly Pro
145                 150                 155                 160 
Pro Pro Lys Arg Ser Ala Pro Ser Gly Pro Val Arg Ser Ser Ser Gly
                165                 170                 175     
Met Gly Gly Arg Ala Pro Val Ser Arg Gly Arg Asp Ser Tyr Gly Gly
            180                 185                 190         
Pro Pro Arg Arg Glu Pro Leu Pro Ser Arg Arg Asp Val Tyr Leu Ser
        195                 200                 205             
Pro Arg Asp Asp Gly Tyr Ser Thr Lys Asp Ser Tyr Ser Ser Arg Asp
    210                 215                 220                 
Tyr Pro Ser Ser Arg Asp Thr Arg Asp Tyr Ala Pro Pro Pro Arg Asp
225                 230                 235                 240 
Tyr Thr Tyr Arg Asp Tyr Gly His Ser Ser Ser Arg Asp Asp Tyr Pro
                245                 250                 255     
Ser Arg Gly Tyr Ser Asp Arg Asp Gly Tyr Gly Arg Asp Arg Asp Tyr
            260                 265                 270         
Ser Asp His Pro Ser Gly Gly Ser Tyr Arg Asp Ser Tyr Glu Ser Tyr
        275                 280                 285             
Gly Asn Ser Arg Ser Ala Pro Pro Thr Arg Gly Pro Pro Pro Ser Tyr
    290                 295                 300                 
Gly Gly Ser Ser Arg Tyr Asp Asp Tyr Ser Ser Ser Arg Asp Gly Tyr
305                 310                 315                 320 
Gly Gly Ser Arg Asp Ser Tyr Ser Ser Ser Arg Ser Asp Leu Tyr Ser
                325                 330                 335     
Ser Gly Arg Asp Arg Val Gly Arg Gln Glu Arg Gly Leu Pro Pro Ser
            340                 345                 350         
Met Glu Arg Gly Tyr Pro Pro Pro Arg Asp Ser Tyr Ser Ser Ser Ser
        355                 360                 365             
Arg Gly Ala Pro Arg Gly Gly Gly Arg Gly Gly Ser Arg Ser Asp Arg
    370                 375                 380                 
Gly Gly Gly Arg Ser Arg Tyr
385                 390     


<210> 7517
<211> 1097
<212> PRT
<213> Homo sapiens

<400> 7517
Met Leu Lys Pro Gln Pro Leu Gln Gln Pro Ser Gln Pro Gln Gln Pro
 1               5                  10                  15      
Pro Pro Thr Gln Gln Ala Val Ala Arg Arg Pro Pro Gly Gly Thr Ser
            20                  25                  30          
Pro Pro Asn Gly Gly Leu Pro Gly Pro Leu Ala Thr Ser Ala Ala Pro
        35                  40                  45              
Pro Gly Pro Pro Ala Ala Ala Ser Pro Cys Leu Gly Pro Val Ala Ala
    50                  55                  60                  
Ala Gly Ser Gly Leu Arg Arg Gly Ala Glu Gly Ile Leu Ala Pro Gln
65                  70                  75                  80  
Pro Pro Pro Pro Gln Gln His Gln Glu Arg Pro Gly Ala Ala Ala Ile
                85                  90                  95      
Gly Ser Ala Arg Gly Gln Ser Thr Gly Lys Gly Pro Pro Gln Ser Pro
            100                 105                 110         
Val Phe Glu Gly Val Tyr Asn Asn Ser Arg Met Leu His Phe Leu Thr
        115                 120                 125             
Ala Val Val Gly Ser Thr Cys Asp Val Lys Val Lys Asn Gly Thr Thr
    130                 135                 140                 
Tyr Glu Gly Ile Phe Lys Thr Leu Ser Ser Lys Phe Glu Leu Ala Val
145                 150                 155                 160 
Asp Ala Val His Arg Lys Ala Ser Glu Pro Ala Gly Gly Pro Arg Arg
                165                 170                 175     
Glu Asp Ile Val Asp Thr Met Val Phe Lys Pro Ser Asp Val Met Leu
            180                 185                 190         
Val His Phe Arg Asn Val Asp Phe Asn Tyr Ala Thr Lys Asp Lys Phe
        195                 200                 205             
Thr Asp Ser Ala Ile Ala Met Asn Ser Lys Val Asn Gly Glu His Lys
    210                 215                 220                 
Glu Lys Val Leu Gln Arg Trp Glu Gly Gly Asp Ser Asn Ser Asp Asp
225                 230                 235                 240 
Tyr Asp Leu Glu Ser Asp Met Ser Asn Gly Trp Asp Pro Asn Glu Met
                245                 250                 255     
Phe Lys Phe Asn Glu Glu Asn Tyr Gly Val Lys Thr Thr Tyr Asp Ser
            260                 265                 270         
Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Lys Asp Asn Ser Glu Glu
        275                 280                 285             
Phe Arg Gln Arg Glu Leu Arg Ala Ala Gln Leu Ala Arg Glu Ile Glu
    290                 295                 300                 
Ser Ser Pro Gln Tyr Arg Leu Arg Ile Ala Met Glu Asn Asp Asp Gly
305                 310                 315                 320 
Arg Thr Glu Glu Glu Lys His Ser Ala Val Gln Arg Gln Gly Ser Gly
                325                 330                 335     
Arg Glu Ser Pro Ser Leu Ala Ser Arg Glu Gly Lys Tyr Ile Pro Leu
            340                 345                 350         
Pro Gln Arg Val Arg Glu Gly Pro Arg Gly Gly Val Arg Cys Ser Ser
        355                 360                 365             
Ser Arg Gly Gly Arg Pro Gly Leu Ser Ser Leu Pro Pro Arg Gly Pro
    370                 375                 380                 
His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser Glu Ala Arg Gly
385                 390                 395                 400 
Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala Gln Arg Pro Leu
                405                 410                 415     
Arg Gly Ala Lys Thr Leu Ser Ser Pro Ser Asn Arg Pro Ser Gly Glu
            420                 425                 430         
Thr Ser Val Pro Pro Pro Pro Ala Val Gly Arg Met Tyr Pro Pro Arg
        435                 440                 445             
Ser Pro Lys Ser Ala Ala Pro Ala Pro Ile Ser Ala Ser Cys Pro Glu
    450                 455                 460                 
Pro Pro Ile Gly Ser Ala Val Pro Thr Ser Ser Ala Ser Ile Pro Val
465                 470                 475                 480 
Thr Ser Ser Val Ser Asp Pro Gly Val Gly Ser Ile Ser Pro Ala Ser
                485                 490                 495     
Pro Lys Ile Ser Leu Ala Pro Thr Asp Val Lys Glu Leu Ser Thr Lys
            500                 505                 510         
Glu Pro Gly Arg Thr Leu Glu Pro Gln Glu Leu Ala Arg Ile Ala Gly
        515                 520                 525             
Lys Val Pro Gly Leu Gln Asn Glu Gln Lys Arg Phe Gln Leu Glu Glu
    530                 535                 540                 
Leu Arg Lys Phe Gly Ala Gln Phe Lys Leu Gln Pro Ser Ser Ser Pro
545                 550                 555                 560 
Glu Asn Ser Leu Asp Pro Phe Pro Pro Arg Ile Leu Lys Glu Glu Pro
                565                 570                 575     
Lys Gly Lys Glu Lys Glu Val Asp Gly Leu Leu Thr Ser Glu Pro Met
            580                 585                 590         
Gly Ser Pro Val Ser Ser Lys Thr Glu Ser Val Ser Asp Lys Glu Asp
        595                 600                 605             
Lys Pro Pro Leu Ala Pro Ser Gly Gly Thr Glu Gly Pro Glu Gln Pro
    610                 615                 620                 
Pro Pro Pro Cys Pro Ser Gln Thr Gly Ser Pro Pro Val Gly Leu Ile
625                 630                 635                 640 
Lys Gly Glu Asp Lys Asp Glu Gly Pro Val Ala Glu Gln Val Lys Lys
                645                 650                 655     
Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Thr Lys Pro Leu
            660                 665                 670         
Leu Ser Val Asn Lys Ser Thr Ser Thr Pro Thr Ser Pro Gly Pro Arg
        675                 680                 685             
Ser His Ser Thr Pro Ser Ile Pro Val Leu Thr Ala Gly Gln Ser Gly
    690                 695                 700                 
Leu Tyr Ser Pro Gln Tyr Ile Ser Tyr Ile Pro Gln Ile His Met Gly
705                 710                 715                 720 
Pro Ala Val Gln Ala Thr Gln Met Tyr Pro Tyr Pro Val Ser Asn Ser
                725                 730                 735     
Val Pro Gly Gln Gln Gly Lys Tyr Arg Gly Ala Lys Gly Ser Leu Pro
            740                 745                 750         
Pro Gln Arg Ser Asp Gln His Gln Pro Ala Ser Ala Pro Pro Met Met
        755                 760                 765             
Gln Ala Ala Ala Ala Ala Gly Pro Pro Leu Val Ala Ala Thr Pro Tyr
    770                 775                 780                 
Ser Ser Tyr Ile Pro Tyr Asn Pro Gln Gln Phe Pro Gly Gln Pro Ala
785                 790                 795                 800 
Met Met Gln Pro Met Ala His Tyr Pro Ser Gln Pro Val Phe Ala Pro
                805                 810                 815     
Met Leu Gln Ser Asn Pro Arg Met Leu Thr Ser Gly Ser His Pro Gln
            820                 825                 830         
Ala Ile Val Ser Ser Ser Thr Pro Gln Tyr Pro Ser Ala Glu Gln Pro
        835                 840                 845             
Thr Pro Gln Ala Leu Tyr Ala Thr Val His Gln Ser Tyr Pro His His
    850                 855                 860                 
Ala Thr Gln Leu His Ala His Gln Pro Gln Pro Ala Thr Thr Pro Thr
865                 870                 875                 880 
Gly Ser Gln Pro Gln Ser Gln His Ala Ala Pro Ser Pro Val Gln His
                885                 890                 895     
Gln Ala Gly Gln Ala Pro His Leu Gly Ser Gly Gln Pro Gln Gln Asn
            900                 905                 910         
Leu Tyr His Pro Gly Ala Leu Thr Gly Thr Pro Pro Ser Leu Pro Pro
        915                 920                 925             
Gly Pro Ser Ala Gln Ser Pro Gln Ser Ser Phe Pro Gln Pro Ala Ala
    930                 935                 940                 
Val Tyr Ala Ile His His Gln Gln Leu Pro His Gly Phe Thr Asn Met
945                 950                 955                 960 
Ala His Val Thr Gln Ala His Val Gln Thr Gly Ile Thr Ala Ala Pro
                965                 970                 975     
Pro Pro His Pro Gly Ala Pro His Pro Pro Gln Val Met Leu Leu His
            980                 985                 990         
Pro Pro Gln Ser His Gly Gly Pro Pro Gln Gly Ala Val Pro Gln Ser
        995                 1000                1005            
Gly Val Pro Ala Leu Ser Ala Ser Thr Pro Ser Pro Tyr Pro Tyr Ile
    1010                1015                1020                
Gly His Pro Gln Gly Glu Gln Pro Gly Gln Ala Pro Gly Phe Pro Gly
1025                1030                1035                1040
Gly Ala Asp Asp Arg Ile Leu Cys Arg Val Gly Arg Ser His Ser Arg
                1045                1050                1055    
Arg Arg Gln Gly Leu Ala Pro Gly Ser Val Leu Cys Phe Pro Pro Ser
            1060                1065                1070        
Ser Leu Ser Cys Asp Pro Ala Ala Pro Leu Pro Thr Ala Ser Pro Ala
        1075                1080                1085            
Leu Ser Asp Pro Asp Cys Leu Leu Thr
    1090                1095        


<210> 7518
<211> 1051
<212> PRT
<213> Homo sapiens

<400> 7518
Met Gly Trp Arg Pro Gly Arg Asp Ala Pro His Phe Pro Pro Ala Ala
 1               5                  10                  15      
Arg Pro Pro Pro Leu Pro Pro Arg Gly Ala Ser Ser Arg Arg Gly Phe
            20                  25                  30          
Leu Ser Pro Pro Pro Thr Pro Arg Gly Ser Pro Arg Pro Pro Thr Ala
        35                  40                  45              
Gly Pro Gly Cys Pro Ile Pro Leu Ala Ser Arg Ala Leu Gln Arg Gly
    50                  55                  60                  
Pro Ser Pro Gly Pro Leu Ser Pro Ser Leu Leu Ser Asn Ser Pro Ser
65                  70                  75                  80  
Gly Arg Cys His His Val Glu Ala Ser Ala Ala Thr Thr Ala Leu Pro
                85                  90                  95      
Ala Pro Ala Ala Ala Pro His Ala Thr Cys Arg Gly Pro Ser Ala Pro
            100                 105                 110         
Arg Gly His Ser Pro Pro Asn Gly Gly Leu Pro Gly Pro Leu Ala Thr
        115                 120                 125             
Ser Ala Ala Pro Pro Gly Pro Pro Ala Ala Ala Ser Pro Cys Leu Gly
    130                 135                 140                 
Pro Val Ala Ala Ala Gly Ser Gly Leu Arg Arg Gly Ala Glu Gly Ile
145                 150                 155                 160 
Leu Ala Pro Gln Pro Pro Pro Pro Gln Gln His Gln Glu Arg Pro Gly
                165                 170                 175     
Ala Ala Ala Ile Gly Ser Ala Arg Gly Gln Ser Thr Gly Lys Gly Pro
            180                 185                 190         
Pro Gln Ser Pro Val Phe Glu Gly Val Tyr Asn Asn Ser Arg Met Leu
        195                 200                 205             
His Phe Leu Thr Ala Val Val Gly Ser Thr Cys Asp Val Lys Val Lys
    210                 215                 220                 
Asn Gly Thr Thr Tyr Glu Gly Ile Phe Lys Thr Leu Ser Ser Lys Phe
225                 230                 235                 240 
Glu Leu Ala Val Asp Ala Val His Arg Lys Ala Ser Glu Pro Ala Gly
                245                 250                 255     
Gly Pro Arg Arg Glu Asp Ile Val Asp Thr Met Val Phe Lys Pro Ser
            260                 265                 270         
Asp Val Met Leu Val His Phe Arg Asn Val Asp Phe Asn Tyr Ala Thr
        275                 280                 285             
Lys Asp Lys Phe Thr Asp Ser Ala Ile Ala Met Asn Ser Lys Val Asn
    290                 295                 300                 
Gly Glu His Lys Glu Lys Val Leu Gln Arg Trp Glu Gly Gly Asp Ser
305                 310                 315                 320 
Asn Ser Asp Asp Tyr Asp Leu Glu Ser Asp Met Ser Asn Gly Trp Asp
                325                 330                 335     
Pro Asn Glu Met Phe Lys Phe Asn Glu Glu Asn Tyr Gly Val Lys Thr
            340                 345                 350         
Thr Tyr Asp Ser Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Lys Asp
        355                 360                 365             
Asn Ser Glu Glu Phe Arg Gln Arg Glu Leu Arg Ala Ala Gln Leu Ala
    370                 375                 380                 
Arg Glu Ile Glu Ser Ser Pro Gln Tyr Arg Leu Arg Ile Ala Met Glu
385                 390                 395                 400 
Asn Asp Asp Gly Arg Thr Glu Glu Glu Lys His Ser Ala Val Gln Arg
                405                 410                 415     
Gln Gly Ser Gly Arg Glu Ser Pro Ser Leu Ala Ser Arg Glu Gly Lys
            420                 425                 430         
Tyr Ile Pro Leu Pro Gln Arg Val Arg Glu Gly Pro Arg Gly Gly Val
        435                 440                 445             
Arg Cys Ser Ser Ser Arg Gly Gly Arg Pro Gly Leu Ser Ser Leu Pro
    450                 455                 460                 
Pro Arg Gly Pro His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser
465                 470                 475                 480 
Glu Ala Arg Gly Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala
                485                 490                 495     
Gln Arg Pro Leu Arg Gly Ala Lys Thr Leu Ser Ser Pro Ser Asn Arg
            500                 505                 510         
Leu Leu Glu Asn Phe Cys Ser Thr Ser Ser Cys Ser Gly Pro Asp Val
        515                 520                 525             
Ser Pro Arg Ser Pro Lys Ser Ala Ala Pro Ala Pro Ile Ser Ala Ser
    530                 535                 540                 
Cys Pro Glu Pro Pro Ile Gly Ser Ala Val Pro Thr Ser Ser Ala Ser
545                 550                 555                 560 
Ile Pro Val Thr Ser Ser Val Ser Asp Pro Gly Val Gly Ser Ile Ser
                565                 570                 575     
Pro Ala Ser Pro Lys Ile Ser Leu Ala Pro Thr Asp Val Lys Glu Leu
            580                 585                 590         
Ser Thr Lys Glu Pro Gly Arg Thr Leu Glu Pro Gln Glu Leu Ala Arg
        595                 600                 605             
Ile Ala Gly Lys Val Pro Gly Leu Gln Asn Glu Gln Lys Arg Phe Gln
    610                 615                 620                 
Leu Glu Glu Leu Arg Lys Phe Gly Ala Gln Phe Lys Leu Gln Pro Ser
625                 630                 635                 640 
Ser Ser Pro Glu Asn Ser Leu Asp Pro Phe Pro Pro Arg Ile Leu Lys
                645                 650                 655     
Glu Glu Pro Lys Gly Lys Glu Lys Glu Val Asp Gly Leu Leu Thr Ser
            660                 665                 670         
Glu Pro Met Gly Ser Pro Val Ser Ser Lys Thr Glu Ser Val Ser Asp
        675                 680                 685             
Lys Glu Asp Lys Pro Pro Leu Ala Pro Ser Gly Gly Thr Glu Gly Pro
    690                 695                 700                 
Glu Gln Pro Pro Pro Pro Cys Pro Ser Gln Thr Gly Ser Pro Pro Val
705                 710                 715                 720 
Gly Leu Ile Lys Gly Glu Asp Lys Asp Glu Gly Pro Val Ala Glu Gln
                725                 730                 735     
Val Lys Lys Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Thr
            740                 745                 750         
Lys Pro Leu Leu Ser Val Asn Lys Ser Thr Ser Thr Pro Thr Ser Pro
        755                 760                 765             
Gly Pro Arg Thr His Ser Thr Pro Ser Ile Pro Val Leu Thr Ala Gly
    770                 775                 780                 
Gln Ser Gly Leu Tyr Ser Pro Gln Tyr Ile Ser Tyr Ile Pro Gln Ile
785                 790                 795                 800 
His Met Gly Pro Ala Val Gln Ala Pro Gln Met Tyr Pro Tyr Pro Val
                805                 810                 815     
Ser Asn Ser Val Pro Gly Gln Gln Gly Lys Tyr Arg Gly Ala Lys Gly
            820                 825                 830         
Ser Leu Pro Pro Gln Arg Ser Asp Gln His Gln Pro Ala Ser Ala Pro
        835                 840                 845             
Pro Met Met Gln Ala Ala Ala Ala Ala Gly Pro Pro Leu Val Ala Ala
    850                 855                 860                 
Thr Pro Tyr Ser Ser Tyr Ile Pro Tyr Asn Pro Gln Gln Phe Pro Gly
865                 870                 875                 880 
Gln Pro Ala Met Met Gln Pro Met Ala His Tyr Pro Ser Gln Pro Val
                885                 890                 895     
Phe Ala Pro Met Leu Gln Ser Asn Pro Arg Met Leu Thr Ser Gly Ser
            900                 905                 910         
His Pro Gln Ala Ile Val Ser Ser Ser Thr Pro Gln Tyr Pro Ser Ala
        915                 920                 925             
Glu Gln Pro Thr Pro Gln Ala Leu Tyr Ala Thr Val His Gln Ser Tyr
    930                 935                 940                 
Pro His His Ala Thr Gln Leu His Ala His Gln Pro Gln Pro Ala Thr
945                 950                 955                 960 
Thr Pro Thr Gly Ser Gln Pro Gln Ser Gln His Ala Ala Pro Ser Pro
                965                 970                 975     
Val Gln Val Pro Ala Met Gly Gly Ala Glu Trp Ser Trp Cys Arg Asn
            980                 985                 990         
Gly Trp Pro Glu Glu Gly Ile Glu Leu Gly Val Ile Ser Glu Trp Arg
        995                 1000                1005            
Gly Leu Gly Ala Ser Glu Leu Leu Ala Cys Val Ala Leu Asn Leu Pro
    1010                1015                1020                
Leu Pro Ser Ser Ile Arg Arg Gly Arg Pro His Thr Trp Ala Val Asp
1025                1030                1035                1040
Ser His Ser Arg Ile Cys Thr Thr Gln Gly Pro
                1045                1050    


<210> 7519
<211> 1044
<212> PRT
<213> Homo sapiens

<400> 7519
Met Leu Lys Pro Gln Pro Leu Gln Gln Pro Ser Gln Pro Gln Gln Pro
 1               5                  10                  15      
Pro Pro Thr Gln Gln Ala Val Ala Arg Arg Pro Pro Gly Gly Thr Ser
            20                  25                  30          
Pro Pro Asn Gly Gly Leu Pro Gly Pro Leu Ala Thr Ser Ala Ala Pro
        35                  40                  45              
Pro Gly Pro Pro Ala Ala Ala Ser Pro Cys Leu Gly Pro Val Ala Ala
    50                  55                  60                  
Ala Gly Ser Gly Leu Arg Arg Gly Ala Glu Gly Ile Leu Ala Pro Gln
65                  70                  75                  80  
Pro Pro Pro Pro Gln Gln His Gln Glu Arg Pro Gly Ala Ala Ala Ile
                85                  90                  95      
Gly Ser Ala Arg Gly Gln Ser Thr Gly Lys Gly Pro Pro Gln Ser Pro
            100                 105                 110         
Val Phe Glu Gly Val Tyr Asn Asn Ser Arg Met Leu His Phe Leu Thr
        115                 120                 125             
Ala Val Val Gly Ser Thr Cys Asp Val Lys Val Lys Asn Gly Thr Thr
    130                 135                 140                 
Tyr Glu Gly Ile Phe Lys Thr Leu Ser Ser Lys Phe Glu Leu Ala Val
145                 150                 155                 160 
Asp Ala Val His Arg Lys Ala Ser Glu Pro Ala Gly Gly Pro Arg Arg
                165                 170                 175     
Glu Asp Ile Val Asp Thr Met Val Phe Lys Pro Ser Asp Val Met Leu
            180                 185                 190         
Val His Phe Arg Asn Val Asp Phe Asn Tyr Ala Thr Lys Asp Lys Phe
        195                 200                 205             
Thr Asp Ser Ala Ile Ala Met Asn Ser Lys Val Asn Gly Glu His Lys
    210                 215                 220                 
Glu Lys Val Leu Gln Arg Trp Glu Gly Gly Asp Ser Asn Ser Asp Asp
225                 230                 235                 240 
Tyr Asp Leu Glu Ser Asp Met Ser Asn Gly Trp Asp Pro Asn Glu Met
                245                 250                 255     
Phe Lys Phe Asn Glu Glu Asn Tyr Gly Val Lys Thr Thr Tyr Asp Ser
            260                 265                 270         
Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Lys Asp Asn Ser Glu Glu
        275                 280                 285             
Phe Arg Gln Arg Glu Leu Arg Ala Ala Gln Leu Ala Arg Glu Ile Glu
    290                 295                 300                 
Ser Ser Pro Gln Tyr Arg Leu Arg Ile Ala Met Glu Asn Asp Asp Gly
305                 310                 315                 320 
Arg Thr Glu Glu Glu Lys His Ser Ala Val Gln Arg Gln Gly Ser Gly
                325                 330                 335     
Arg Glu Ser Pro Ser Leu Ala Ser Arg Glu Gly Lys Tyr Ile Pro Leu
            340                 345                 350         
Pro Gln Arg Val Arg Glu Gly Pro Arg Gly Gly Val Arg Cys Ser Ser
        355                 360                 365             
Ser Arg Gly Gly Arg Pro Gly Leu Ser Ser Leu Pro Pro Arg Gly Pro
    370                 375                 380                 
His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser Glu Ala Arg Gly
385                 390                 395                 400 
Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala Gln Arg Pro Leu
                405                 410                 415     
Arg Gly Ala Lys Thr Leu Ser Ser Pro Ser Asn Arg Pro Ser Gly Glu
            420                 425                 430         
Thr Ser Val Pro Pro Pro Pro Ala Val Gly Arg Met Tyr Pro Pro Arg
        435                 440                 445             
Ser Pro Lys Ser Ala Ala Pro Ala Pro Ile Ser Ala Ser Cys Pro Glu
    450                 455                 460                 
Pro Pro Ile Gly Ser Ala Val Pro Thr Ser Ser Ala Ser Ile Pro Val
465                 470                 475                 480 
Thr Ser Ser Val Ser Asp Pro Gly Val Gly Ser Ile Ser Pro Ala Ser
                485                 490                 495     
Pro Lys Ile Ser Leu Ala Pro Thr Asp Val Lys Glu Leu Ser Thr Lys
            500                 505                 510         
Glu Pro Gly Arg Thr Leu Glu Pro Gln Glu Leu Ala Arg Ile Ala Gly
        515                 520                 525             
Lys Val Pro Gly Leu Gln Asn Glu Gln Lys Arg Phe Gln Leu Glu Glu
    530                 535                 540                 
Leu Arg Lys Phe Gly Ala Gln Phe Lys Leu Gln Pro Ser Ser Ser Pro
545                 550                 555                 560 
Glu Asn Ser Leu Asp Pro Phe Pro Pro Arg Ile Leu Lys Glu Glu Pro
                565                 570                 575     
Lys Gly Lys Glu Lys Glu Val Asp Gly Leu Leu Thr Ser Glu Pro Met
            580                 585                 590         
Gly Ser Pro Val Ser Ser Lys Thr Glu Ser Val Ser Asp Lys Glu Asp
        595                 600                 605             
Lys Pro Pro Leu Ala Pro Ser Gly Gly Thr Glu Gly Pro Glu Gln Pro
    610                 615                 620                 
Pro Pro Pro Cys Pro Ser Gln Thr Gly Ser Pro Pro Val Gly Leu Ile
625                 630                 635                 640 
Lys Gly Glu Asp Lys Asp Glu Gly Pro Val Ala Glu Gln Val Lys Lys
                645                 650                 655     
Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Thr Lys Pro Leu
            660                 665                 670         
Leu Ser Val Asn Lys Ser Thr Ser Thr Pro Thr Ser Pro Gly Pro Arg
        675                 680                 685             
Ser His Ser Thr Pro Ser Ile Pro Val Leu Thr Ala Gly Gln Ser Gly
    690                 695                 700                 
Leu Tyr Ser Pro Gln Tyr Ile Ser Tyr Ile Pro Gln Ile His Met Gly
705                 710                 715                 720 
Pro Ala Val Gln Ala Thr Gln Met Tyr Pro Tyr Pro Val Ser Asn Ser
                725                 730                 735     
Val Pro Gly Gln Gln Gly Lys Tyr Arg Gly Ala Lys Gly Ser Leu Pro
            740                 745                 750         
Pro Gln Arg Ser Asp Gln His Gln Pro Ala Ser Ala Pro Pro Met Met
        755                 760                 765             
Gln Ala Ala Ala Ala Ala Gly Pro Pro Leu Val Ala Ala Thr Pro Tyr
    770                 775                 780                 
Ser Ser Tyr Ile Pro Tyr Asn Pro Gln Gln Phe Pro Gly Gln Pro Ala
785                 790                 795                 800 
Met Met Gln Pro Met Ala His Tyr Pro Ser Gln Pro Val Phe Ala Pro
                805                 810                 815     
Met Leu Gln Ser Asn Pro Arg Met Leu Thr Ser Gly Ser His Pro Gln
            820                 825                 830         
Ala Ile Val Ser Ser Ser Thr Pro Gln Tyr Pro Ser Ala Glu Gln Pro
        835                 840                 845             
Thr Pro Gln Ala Leu Tyr Ala Thr Val His Gln Ser Tyr Pro His His
    850                 855                 860                 
Ala Thr Gln Leu His Ala His Gln Pro Gln Pro Ala Thr Thr Pro Thr
865                 870                 875                 880 
Gly Ser Gln Pro Gln Ser Gln His Ala Ala Pro Ser Pro Val Gln His
                885                 890                 895     
Gln Ala Gly Gln Ala Pro His Leu Gly Ser Gly Gln Pro Gln Gln Asn
            900                 905                 910         
Leu Tyr His Pro Gly Ala Leu Thr Gly Thr Pro Pro Ser Leu Pro Pro
        915                 920                 925             
Gly Pro Ser Ala Gln Ser Pro Gln Ser Ser Phe Pro Gln Pro Ala Ala
    930                 935                 940                 
Val Tyr Ala Ile His His Gln Gln Leu Pro His Gly Phe Thr Asn Met
945                 950                 955                 960 
Ala His Val Thr Gln Ala His Val Gln Thr Gly Ile Thr Ala Ala Pro
                965                 970                 975     
Pro Pro His Pro Gly Ala Pro His Pro Pro Gln Val Met Leu Leu His
            980                 985                 990         
Pro Pro Gln Ser His Gly Gly Pro Pro Gln Gly Ala Val Pro Gln Ser
        995                 1000                1005            
Gly Val Pro Ala Leu Ser Ala Ser Thr Pro Ser Pro Tyr Pro Tyr Ile
    1010                1015                1020                
Gly His Pro Gln Val Gln Ser His Pro Ser Gln Gln Leu Pro Phe His
1025                1030                1035                1040
Pro Pro Gly Asn
                


<210> 7520
<211> 1075
<212> PRT
<213> Homo sapiens

<400> 7520
Met Leu Lys Pro Gln Pro Leu Gln Gln Pro Ser Gln Pro Gln Gln Pro
 1               5                  10                  15      
Pro Pro Thr Gln Gln Ala Val Ala Arg Arg Pro Pro Gly Gly Thr Ser
            20                  25                  30          
Pro Pro Asn Gly Gly Leu Pro Gly Pro Leu Ala Thr Ser Ala Ala Pro
        35                  40                  45              
Pro Gly Pro Pro Ala Ala Ala Ser Pro Cys Leu Gly Pro Val Ala Ala
    50                  55                  60                  
Ala Gly Ser Gly Leu Arg Arg Gly Ala Glu Gly Ile Leu Ala Pro Gln
65                  70                  75                  80  
Pro Pro Pro Pro Gln Gln His Gln Glu Arg Pro Gly Ala Ala Ala Ile
                85                  90                  95      
Gly Ser Ala Arg Gly Gln Ser Thr Gly Lys Gly Pro Pro Gln Ser Pro
            100                 105                 110         
Val Phe Glu Gly Val Tyr Asn Asn Ser Arg Met Leu His Phe Leu Thr
        115                 120                 125             
Ala Val Val Gly Ser Thr Cys Asp Val Lys Val Lys Asn Gly Thr Thr
    130                 135                 140                 
Tyr Glu Gly Ile Phe Lys Thr Leu Ser Ser Lys Phe Glu Leu Ala Val
145                 150                 155                 160 
Asp Ala Val His Arg Lys Ala Ser Glu Pro Ala Gly Gly Pro Arg Arg
                165                 170                 175     
Glu Asp Ile Val Asp Thr Met Val Phe Lys Pro Ser Asp Val Met Leu
            180                 185                 190         
Val His Phe Arg Asn Val Asp Phe Asn Tyr Ala Thr Lys Asp Lys Phe
        195                 200                 205             
Thr Asp Ser Ala Ile Ala Met Asn Ser Lys Val Asn Gly Glu His Lys
    210                 215                 220                 
Glu Lys Val Leu Gln Arg Trp Glu Gly Gly Asp Ser Asn Ser Asp Asp
225                 230                 235                 240 
Tyr Asp Leu Glu Ser Asp Met Ser Asn Gly Trp Asp Pro Asn Glu Met
                245                 250                 255     
Phe Lys Phe Asn Glu Glu Asn Tyr Gly Val Lys Thr Thr Tyr Asp Ser
            260                 265                 270         
Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Lys Asp Asn Ser Glu Glu
        275                 280                 285             
Phe Arg Gln Arg Glu Leu Arg Ala Ala Gln Leu Ala Arg Glu Ile Glu
    290                 295                 300                 
Ser Ser Pro Gln Tyr Arg Leu Arg Ile Ala Met Glu Asn Asp Asp Gly
305                 310                 315                 320 
Arg Thr Glu Glu Glu Lys His Ser Ala Val Gln Arg Gln Gly Ser Gly
                325                 330                 335     
Arg Glu Ser Pro Ser Leu Ala Ser Arg Glu Gly Lys Tyr Ile Pro Leu
            340                 345                 350         
Pro Gln Arg Val Arg Glu Gly Pro Arg Gly Gly Val Arg Cys Ser Ser
        355                 360                 365             
Ser Arg Gly Gly Arg Pro Gly Leu Ser Ser Leu Pro Pro Arg Gly Pro
    370                 375                 380                 
His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser Glu Ala Arg Gly
385                 390                 395                 400 
Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala Gln Arg Pro Leu
                405                 410                 415     
Arg Gly Ala Lys Thr Leu Ser Ser Pro Ser Asn Arg Pro Ser Gly Glu
            420                 425                 430         
Thr Ser Val Pro Pro Pro Pro Ala Val Gly Arg Met Tyr Pro Pro Arg
        435                 440                 445             
Ser Pro Lys Ser Ala Ala Pro Ala Pro Ile Ser Ala Ser Cys Pro Glu
    450                 455                 460                 
Pro Pro Ile Gly Ser Ala Val Pro Thr Ser Ser Ala Ser Ile Pro Val
465                 470                 475                 480 
Thr Ser Ser Val Ser Asp Pro Gly Val Gly Ser Ile Ser Pro Ala Ser
                485                 490                 495     
Pro Lys Ile Ser Leu Ala Pro Thr Asp Val Lys Glu Leu Ser Thr Lys
            500                 505                 510         
Glu Pro Gly Arg Thr Leu Glu Pro Gln Glu Leu Ala Arg Ile Ala Gly
        515                 520                 525             
Lys Val Pro Gly Leu Gln Asn Glu Gln Lys Arg Phe Gln Leu Glu Glu
    530                 535                 540                 
Leu Arg Lys Phe Gly Ala Gln Phe Lys Leu Gln Pro Ser Ser Ser Pro
545                 550                 555                 560 
Glu Asn Ser Leu Asp Pro Phe Pro Pro Arg Ile Leu Lys Glu Glu Pro
                565                 570                 575     
Lys Gly Lys Glu Lys Glu Val Asp Gly Leu Leu Thr Ser Glu Pro Met
            580                 585                 590         
Gly Ser Pro Val Ser Ser Lys Thr Glu Ser Val Ser Asp Lys Glu Asp
        595                 600                 605             
Lys Pro Pro Leu Ala Pro Ser Gly Gly Thr Glu Gly Pro Glu Gln Pro
    610                 615                 620                 
Pro Pro Pro Cys Pro Ser Gln Thr Gly Ser Pro Pro Val Gly Leu Ile
625                 630                 635                 640 
Lys Gly Glu Asp Lys Asp Glu Gly Pro Val Ala Glu Gln Val Lys Lys
                645                 650                 655     
Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Thr Lys Pro Leu
            660                 665                 670         
Leu Ser Val Asn Lys Ser Thr Ser Thr Pro Thr Ser Pro Gly Pro Arg
        675                 680                 685             
Ser His Ser Thr Pro Ser Ile Pro Val Leu Thr Ala Gly Gln Ser Gly
    690                 695                 700                 
Leu Tyr Ser Pro Gln Tyr Ile Ser Tyr Ile Pro Gln Ile His Met Gly
705                 710                 715                 720 
Pro Ala Val Gln Ala Thr Gln Met Tyr Pro Tyr Pro Val Ser Asn Ser
                725                 730                 735     
Val Pro Gly Gln Gln Gly Lys Tyr Arg Gly Ala Lys Gly Ser Leu Pro
            740                 745                 750         
Pro Gln Arg Ser Asp Gln His Gln Pro Ala Ser Ala Pro Pro Met Met
        755                 760                 765             
Gln Ala Ala Ala Ala Ala Gly Pro Pro Leu Val Ala Ala Thr Pro Tyr
    770                 775                 780                 
Ser Ser Tyr Ile Pro Tyr Asn Pro Gln Gln Phe Pro Gly Gln Pro Ala
785                 790                 795                 800 
Met Met Gln Pro Met Ala His Tyr Pro Ser Gln Pro Val Phe Ala Pro
                805                 810                 815     
Met Leu Gln Ser Asn Pro Arg Met Leu Thr Ser Gly Ser His Pro Gln
            820                 825                 830         
Ala Ile Val Ser Ser Ser Thr Pro Gln Tyr Pro Ser Ala Glu Gln Pro
        835                 840                 845             
Thr Pro Gln Ala Leu Tyr Ala Thr Val His Gln Ser Tyr Pro His His
    850                 855                 860                 
Ala Thr Gln Leu His Ala His Gln Pro Gln Pro Ala Thr Thr Pro Thr
865                 870                 875                 880 
Gly Ser Gln Pro Gln Ser Gln His Ala Ala Pro Ser Pro Val Gln His
                885                 890                 895     
Gln Ala Gly Gln Ala Pro His Leu Gly Ser Gly Gln Pro Gln Gln Asn
            900                 905                 910         
Leu Tyr His Pro Gly Ala Leu Thr Gly Thr Pro Pro Ser Leu Pro Pro
        915                 920                 925             
Gly Pro Ser Ala Gln Ser Pro Gln Ser Ser Phe Pro Gln Pro Ala Ala
    930                 935                 940                 
Val Tyr Ala Ile His His Gln Gln Leu Pro His Gly Phe Thr Asn Met
945                 950                 955                 960 
Ala His Val Thr Gln Ala His Val Gln Thr Gly Ile Thr Ala Ala Pro
                965                 970                 975     
Pro Pro His Pro Gly Ala Pro His Pro Pro Gln Val Met Leu Leu His
            980                 985                 990         
Pro Pro Gln Ser His Gly Gly Pro Pro Gln Gly Ala Val Pro Gln Ser
        995                 1000                1005            
Gly Val Pro Ala Leu Ser Ala Ser Thr Pro Ser Pro Tyr Pro Tyr Ile
    1010                1015                1020                
Gly His Pro Gln Gly Glu Gln Pro Gly Gln Ala Pro Gly Phe Pro Gly
1025                1030                1035                1040
Gly Ala Asp Asp Arg Ile Arg Glu Phe Ser Leu Ala Gly Gly Ile Trp
                1045                1050                1055    
His Gly Arg Ala Glu Gly Leu Gln Val Gly Gln Asp Ala Arg Val Leu
            1060                1065                1070        
Gly Gly Glu
        1075


<210> 7521
<211> 1062
<212> PRT
<213> Homo sapiens

<400> 7521
Met Leu Lys Pro Gln Pro Leu Gln Gln Pro Ser Gln Pro Gln Gln Pro
 1               5                  10                  15      
Pro Pro Thr Gln Gln Ala Val Ala Arg Arg Pro Pro Gly Gly Thr Ser
            20                  25                  30          
Pro Pro Asn Gly Gly Leu Pro Gly Pro Leu Ala Thr Ser Ala Ala Pro
        35                  40                  45              
Pro Gly Pro Pro Ala Ala Ala Ser Pro Cys Leu Gly Pro Val Ala Ala
    50                  55                  60                  
Ala Gly Ser Gly Leu Arg Arg Gly Ala Glu Gly Ile Leu Ala Pro Gln
65                  70                  75                  80  
Pro Pro Pro Pro Gln Gln His Gln Glu Arg Pro Gly Ala Ala Ala Ile
                85                  90                  95      
Gly Ser Ala Arg Gly Gln Ser Thr Gly Lys Gly Pro Pro Gln Ser Pro
            100                 105                 110         
Val Phe Glu Gly Val Tyr Asn Asn Ser Arg Met Leu His Phe Leu Thr
        115                 120                 125             
Ala Val Val Gly Ser Thr Cys Asp Val Lys Val Lys Asn Gly Thr Thr
    130                 135                 140                 
Tyr Glu Gly Ile Phe Lys Thr Leu Ser Ser Lys Phe Glu Leu Ala Val
145                 150                 155                 160 
Asp Ala Val His Arg Lys Ala Ser Glu Pro Ala Gly Gly Pro Arg Arg
                165                 170                 175     
Glu Asp Ile Val Asp Thr Met Val Phe Lys Pro Ser Asp Val Met Leu
            180                 185                 190         
Val His Phe Arg Asn Val Asp Phe Asn Tyr Ala Thr Lys Asp Lys Phe
        195                 200                 205             
Thr Asp Ser Ala Ile Ala Met Asn Ser Lys Val Asn Gly Glu His Lys
    210                 215                 220                 
Glu Lys Val Leu Gln Arg Trp Glu Gly Gly Asp Ser Asn Ser Asp Asp
225                 230                 235                 240 
Tyr Asp Leu Glu Ser Asp Met Ser Asn Gly Trp Asp Pro Asn Glu Met
                245                 250                 255     
Phe Lys Phe Asn Glu Glu Asn Tyr Gly Val Lys Thr Thr Tyr Asp Ser
            260                 265                 270         
Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Lys Asp Asn Ser Glu Glu
        275                 280                 285             
Phe Arg Gln Arg Glu Leu Arg Ala Ala Gln Leu Ala Arg Glu Ile Glu
    290                 295                 300                 
Ser Ser Pro Gln Tyr Arg Leu Arg Ile Ala Met Glu Asn Asp Asp Gly
305                 310                 315                 320 
Arg Thr Glu Glu Glu Lys His Ser Ala Val Gln Arg Gln Gly Ser Gly
                325                 330                 335     
Arg Glu Ser Pro Ser Leu Ala Ser Arg Glu Gly Lys Tyr Ile Pro Leu
            340                 345                 350         
Pro Gln Arg Val Arg Glu Gly Pro Arg Gly Gly Val Arg Cys Ser Ser
        355                 360                 365             
Ser Arg Gly Gly Arg Pro Gly Leu Ser Ser Leu Pro Pro Arg Gly Pro
    370                 375                 380                 
His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser Glu Ala Arg Gly
385                 390                 395                 400 
Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala Gln Arg Pro Leu
                405                 410                 415     
Arg Gly Ala Lys Thr Leu Ser Ser Pro Ser Asn Arg Pro Ser Gly Glu
            420                 425                 430         
Thr Ser Val Pro Pro Pro Pro Ala Val Gly Arg Met Tyr Pro Pro Arg
        435                 440                 445             
Ser Pro Lys Ser Ala Ala Pro Ala Pro Ile Ser Ala Ser Cys Pro Glu
    450                 455                 460                 
Pro Pro Ile Gly Ser Ala Val Pro Thr Ser Ser Ala Ser Ile Pro Val
465                 470                 475                 480 
Thr Ser Ser Val Ser Asp Pro Gly Val Gly Ser Ile Ser Pro Ala Ser
                485                 490                 495     
Pro Lys Ile Ser Leu Ala Pro Thr Asp Val Lys Glu Leu Ser Thr Lys
            500                 505                 510         
Glu Pro Gly Arg Thr Leu Glu Pro Gln Glu Leu Ala Arg Ile Ala Gly
        515                 520                 525             
Lys Val Pro Gly Leu Gln Asn Glu Gln Lys Arg Phe Gln Leu Glu Glu
    530                 535                 540                 
Leu Arg Lys Phe Gly Ala Gln Phe Lys Leu Gln Pro Ser Ser Ser Pro
545                 550                 555                 560 
Glu Asn Ser Leu Asp Pro Phe Pro Pro Arg Ile Leu Lys Glu Glu Pro
                565                 570                 575     
Lys Gly Lys Glu Lys Glu Val Asp Gly Leu Leu Thr Ser Glu Pro Met
            580                 585                 590         
Gly Ser Pro Val Ser Ser Lys Thr Glu Ser Val Ser Asp Lys Glu Asp
        595                 600                 605             
Lys Pro Pro Leu Ala Pro Ser Gly Gly Thr Glu Gly Pro Glu Gln Pro
    610                 615                 620                 
Pro Pro Pro Cys Pro Ser Gln Thr Gly Ser Pro Pro Val Gly Leu Ile
625                 630                 635                 640 
Lys Gly Glu Asp Lys Asp Glu Gly Pro Val Ala Glu Gln Val Lys Lys
                645                 650                 655     
Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Thr Lys Pro Leu
            660                 665                 670         
Leu Ser Val Asn Lys Ser Thr Ser Thr Pro Thr Ser Pro Gly Pro Arg
        675                 680                 685             
Ser His Ser Thr Pro Ser Ile Pro Val Leu Thr Ala Gly Gln Ser Gly
    690                 695                 700                 
Leu Tyr Ser Pro Gln Tyr Ile Ser Tyr Ile Pro Gln Ile His Met Gly
705                 710                 715                 720 
Pro Ala Val Gln Ala Thr Gln Met Tyr Pro Tyr Pro Val Ser Asn Ser
                725                 730                 735     
Val Pro Gly Gln Gln Gly Lys Tyr Arg Gly Ala Lys Gly Ser Leu Pro
            740                 745                 750         
Pro Gln Arg Ser Asp Gln His Gln Pro Ala Ser Ala Pro Pro Met Met
        755                 760                 765             
Gln Ala Ala Ala Ala Ala Gly Pro Pro Leu Val Ala Ala Thr Pro Tyr
    770                 775                 780                 
Ser Ser Tyr Ile Pro Tyr Asn Pro Gln Gln Phe Pro Gly Gln Pro Ala
785                 790                 795                 800 
Met Met Gln Pro Met Ala His Tyr Pro Ser Gln Pro Val Phe Ala Pro
                805                 810                 815     
Met Leu Gln Ser Asn Pro Arg Met Leu Thr Ser Gly Ser His Pro Gln
            820                 825                 830         
Ala Ile Val Ser Ser Ser Thr Pro Gln Tyr Pro Ser Ala Glu Gln Pro
        835                 840                 845             
Thr Pro Gln Ala Leu Tyr Ala Thr Val His Gln Ser Tyr Pro His His
    850                 855                 860                 
Ala Thr Gln Leu His Ala His Gln Pro Gln Pro Ala Thr Thr Pro Thr
865                 870                 875                 880 
Gly Ser Gln Pro Gln Ser Gln His Ala Ala Pro Ser Pro Val Gln His
                885                 890                 895     
Gln Ala Gly Gln Ala Pro His Leu Gly Ser Gly Gln Pro Gln Gln Asn
            900                 905                 910         
Leu Tyr His Pro Gly Ala Leu Thr Gly Thr Pro Pro Ser Leu Pro Pro
        915                 920                 925             
Gly Pro Ser Ala Gln Ser Pro Gln Ser Ser Phe Pro Gln Pro Ala Ala
    930                 935                 940                 
Val Tyr Ala Ile His His Gln Gln Leu Pro His Gly Phe Thr Asn Met
945                 950                 955                 960 
Ala His Val Thr Gln Ala His Val Gln Thr Gly Ile Thr Ala Ala Pro
                965                 970                 975     
Pro Pro His Pro Gly Ala Pro His Pro Pro Gln Val Met Leu Leu His
            980                 985                 990         
Pro Pro Gln Ser His Gly Gly Pro Pro Gln Gly Ala Val Pro Gln Ser
        995                 1000                1005            
Gly Val Pro Ala Leu Ser Ala Ser Thr Pro Ser Pro Tyr Pro Tyr Ile
    1010                1015                1020                
Gly His Pro Gln Gly Glu Gln Pro Gly Gln Ala Pro Gly Phe Pro Gly
1025                1030                1035                1040
Gly Ala Asp Asp Arg Ile Pro Pro Phe Pro Pro Pro Gly Glu Leu Lys
                1045                1050                1055    
Ile Val Leu Ala Ala Thr
            1060        


<210> 7522
<211> 1044
<212> PRT
<213> Homo sapiens

<400> 7522
Met Leu Lys Pro Gln Pro Leu Gln Gln Pro Ser Gln Pro Gln Gln Pro
 1               5                  10                  15      
Pro Pro Thr Gln Gln Ala Val Ala Arg Arg Pro Pro Gly Gly Thr Ser
            20                  25                  30          
Pro Pro Asn Gly Gly Leu Pro Gly Pro Leu Ala Thr Ser Ala Ala Pro
        35                  40                  45              
Pro Gly Pro Pro Ala Ala Ala Ser Pro Cys Leu Gly Pro Val Ala Ala
    50                  55                  60                  
Ala Gly Ser Gly Leu Arg Arg Gly Ala Glu Gly Ile Leu Ala Pro Gln
65                  70                  75                  80  
Pro Pro Pro Pro Gln Gln His Gln Glu Arg Pro Gly Ala Ala Ala Ile
                85                  90                  95      
Gly Ser Ala Arg Gly Gln Ser Thr Gly Lys Gly Pro Pro Gln Ser Pro
            100                 105                 110         
Val Phe Glu Gly Val Tyr Asn Asn Ser Arg Met Leu His Phe Leu Thr
        115                 120                 125             
Ala Val Val Gly Ser Thr Cys Asp Val Lys Val Lys Asn Gly Thr Thr
    130                 135                 140                 
Tyr Glu Gly Ile Phe Lys Thr Leu Ser Ser Lys Phe Glu Leu Ala Val
145                 150                 155                 160 
Asp Ala Val His Arg Lys Ala Ser Glu Pro Ala Gly Gly Pro Arg Arg
                165                 170                 175     
Glu Asp Ile Val Asp Thr Met Val Phe Lys Pro Ser Asp Val Met Leu
            180                 185                 190         
Val His Phe Arg Asn Val Asp Phe Asn Tyr Ala Thr Lys Asp Lys Phe
        195                 200                 205             
Thr Asp Ser Ala Ile Ala Met Asn Ser Lys Val Asn Gly Glu His Lys
    210                 215                 220                 
Glu Lys Val Leu Gln Arg Trp Glu Gly Gly Asp Ser Asn Ser Asp Asp
225                 230                 235                 240 
Tyr Asp Leu Glu Ser Asp Met Ser Asn Gly Trp Asp Pro Asn Glu Met
                245                 250                 255     
Phe Lys Phe Asn Glu Glu Asn Tyr Gly Val Lys Thr Thr Tyr Asp Ser
            260                 265                 270         
Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Lys Asp Asn Ser Glu Glu
        275                 280                 285             
Phe Arg Gln Arg Glu Leu Arg Ala Ala Gln Leu Ala Arg Glu Ile Glu
    290                 295                 300                 
Ser Ser Pro Gln Tyr Arg Leu Arg Ile Ala Met Glu Asn Asp Asp Gly
305                 310                 315                 320 
Arg Thr Glu Glu Glu Lys His Ser Ala Val Gln Arg Gln Gly Ser Gly
                325                 330                 335     
Arg Glu Ser Pro Ser Leu Ala Ser Arg Glu Gly Lys Tyr Ile Pro Leu
            340                 345                 350         
Pro Gln Arg Val Arg Glu Gly Pro Arg Gly Gly Val Arg Cys Ser Ser
        355                 360                 365             
Ser Arg Gly Gly Arg Pro Gly Leu Ser Ser Leu Pro Pro Arg Gly Pro
    370                 375                 380                 
His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser Glu Ala Arg Gly
385                 390                 395                 400 
Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala Gln Arg Pro Leu
                405                 410                 415     
Arg Gly Ala Lys Thr Leu Ser Ser Pro Ser Asn Arg Pro Ser Gly Glu
            420                 425                 430         
Thr Ser Val Pro Pro Pro Pro Ala Val Gly Arg Met Tyr Pro Pro Arg
        435                 440                 445             
Ser Pro Lys Ser Ala Ala Pro Ala Pro Ile Ser Ala Ser Cys Pro Glu
    450                 455                 460                 
Pro Pro Ile Gly Ser Ala Val Pro Thr Ser Ser Ala Ser Ile Pro Val
465                 470                 475                 480 
Thr Ser Ser Val Ser Asp Pro Gly Val Gly Ser Ile Ser Pro Ala Ser
                485                 490                 495     
Pro Lys Ile Ser Leu Ala Pro Thr Asp Val Lys Glu Leu Ser Thr Lys
            500                 505                 510         
Glu Pro Gly Arg Thr Leu Glu Pro Gln Glu Leu Ala Arg Ile Ala Gly
        515                 520                 525             
Lys Val Pro Gly Leu Gln Asn Glu Gln Lys Arg Phe Gln Leu Glu Glu
    530                 535                 540                 
Leu Arg Lys Phe Gly Ala Gln Phe Lys Leu Gln Pro Ser Ser Ser Pro
545                 550                 555                 560 
Glu Asn Ser Leu Asp Pro Phe Pro Pro Arg Ile Leu Lys Glu Glu Pro
                565                 570                 575     
Lys Gly Lys Glu Lys Glu Val Asp Gly Leu Leu Thr Ser Glu Pro Met
            580                 585                 590         
Gly Ser Pro Val Ser Ser Lys Thr Glu Ser Val Ser Asp Lys Glu Asp
        595                 600                 605             
Lys Pro Pro Leu Ala Pro Ser Gly Gly Thr Glu Gly Pro Glu Gln Pro
    610                 615                 620                 
Pro Pro Pro Cys Pro Ser Gln Thr Gly Ser Pro Pro Val Gly Leu Ile
625                 630                 635                 640 
Lys Gly Glu Asp Lys Asp Glu Gly Pro Val Ala Glu Gln Val Lys Lys
                645                 650                 655     
Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Thr Lys Pro Leu
            660                 665                 670         
Leu Ser Val Asn Lys Ser Thr Ser Thr Pro Thr Ser Pro Gly Pro Arg
        675                 680                 685             
Ser His Ser Thr Pro Ser Ile Pro Val Leu Thr Ala Gly Gln Ser Gly
    690                 695                 700                 
Leu Tyr Ser Pro Gln Tyr Ile Ser Tyr Ile Pro Gln Ile His Met Gly
705                 710                 715                 720 
Pro Ala Val Gln Ala Thr Gln Met Tyr Pro Tyr Pro Val Ser Asn Ser
                725                 730                 735     
Val Pro Gly Gln Gln Gly Lys Tyr Arg Gly Ala Lys Gly Ser Leu Pro
            740                 745                 750         
Pro Gln Arg Ser Asp Gln His Gln Pro Ala Ser Ala Pro Pro Met Met
        755                 760                 765             
Gln Ala Ala Ala Ala Ala Gly Pro Pro Leu Val Ala Ala Thr Pro Tyr
    770                 775                 780                 
Ser Ser Tyr Ile Pro Tyr Asn Pro Gln Gln Phe Pro Gly Gln Pro Ala
785                 790                 795                 800 
Met Met Gln Pro Met Ala His Tyr Pro Ser Gln Pro Val Phe Ala Pro
                805                 810                 815     
Met Leu Gln Ser Asn Pro Arg Met Leu Thr Ser Gly Ser His Pro Gln
            820                 825                 830         
Ala Ile Val Ser Ser Ser Thr Pro Gln Tyr Pro Ser Ala Glu Gln Pro
        835                 840                 845             
Thr Pro Gln Ala Leu Tyr Ala Thr Val His Gln Ser Tyr Pro His His
    850                 855                 860                 
Ala Thr Gln Leu His Ala His Gln Pro Gln Pro Ala Thr Thr Pro Thr
865                 870                 875                 880 
Gly Ser Gln Pro Gln Ser Gln His Ala Ala Pro Ser Pro Val Gln His
                885                 890                 895     
Gln Ala Gly Gln Ala Pro His Leu Gly Ser Gly Gln Pro Gln Gln Asn
            900                 905                 910         
Leu Tyr His Pro Gly Ala Leu Thr Gly Thr Pro Pro Ser Leu Pro Pro
        915                 920                 925             
Gly Pro Ser Ala Gln Ser Pro Gln Ser Ser Phe Pro Gln Pro Ala Ala
    930                 935                 940                 
Val Tyr Ala Ile His His Gln Gln Leu Pro His Gly Phe Thr Asn Met
945                 950                 955                 960 
Ala His Val Thr Gln Ala His Val Gln Thr Gly Ile Thr Ala Ala Pro
                965                 970                 975     
Pro Pro His Pro Gly Ala Pro His Pro Pro Gln Val Met Leu Leu His
            980                 985                 990         
Pro Pro Gln Ser His Gly Gly Pro Pro Gln Gly Ala Val Pro Gln Ser
        995                 1000                1005            
Gly Val Pro Ala Leu Ser Ala Ser Thr Pro Ser Pro Tyr Pro Tyr Ile
    1010                1015                1020                
Gly His Pro Gln Ala Pro Phe Pro Pro Pro Gly Glu Leu Lys Ile Val
1025                1030                1035                1040
Leu Ala Ala Thr
                


<210> 7523
<211> 210
<212> PRT
<213> Homo sapiens

<400> 7523
Lys Glu Pro Glu Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe
 1               5                  10                  15      
Glu Thr Thr Asp Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr
            20                  25                  30          
Leu Thr Asp Cys Val Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg
        35                  40                  45              
Gly Phe Gly Phe Val Thr Tyr Ser Cys Val Glu Glu Val Asp Ala Ala
    50                  55                  60                  
Met Cys Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys
65                  70                  75                  80  
Arg Ala Val Ser Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr
                85                  90                  95      
Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu Tyr
            100                 105                 110         
Asn Leu Arg Asp Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu
        115                 120                 125             
Val Met Glu Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Phe Val
    130                 135                 140                 
Thr Phe Asp Asp His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr
145                 150                 155                 160 
His Thr Ile Asn Gly His Asn Cys Glu Val Lys Lys Ala Leu Ser Lys
                165                 170                 175     
Gln Glu Met Gln Ser Ala Gly Ser Gln Arg Gly Asn Tyr Gly Gly Gly
            180                 185                 190         
Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser Gly Gln Gln Gln Ser Asn
        195                 200                 205             
Tyr Gly
    210 


<210> 7524
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 7524
Met Ser Ala Leu Cys Asp Pro Pro Gly Ala Pro Gly Pro Pro Gly Pro
 1               5                  10                  15      
Ala Pro Ala Thr His Gly Pro Ala Pro Leu Ser Ala Gln Glu Leu Ser
            20                  25                  30          
Gln Glu Ile Lys Ala Phe Leu Thr Gly Val Asp Pro Ile Leu Gly His
        35                  40                  45              
Gln Leu Ser Ala Arg Glu His Ala Arg Cys Gly Leu Leu Leu Leu Arg
    50                  55                  60                  
Ser Leu Pro Pro Ala Arg Ala Ala Val Leu Asp His Leu Arg Gly Val
65                  70                  75                  80  
Phe Asp Glu Ser Val Arg Ala His Leu Ala Ala Leu Asp Glu Thr Pro
                85                  90                  95      
Val Ala Gly Pro Pro His Leu Arg Pro Pro Pro Pro Ser His Val Pro
            100                 105                 110         
Ala Gly Gly Pro Gly Leu Glu Asp Val Val Gln Glu Val Gln Gln Val
        115                 120                 125             
Leu Ser Glu Phe Ile Arg Ala Asn Pro Lys Ala Trp Ala Pro Val Ile
    130                 135                 140                 
Ser Ala Trp Ser Ile Asp Leu Met Gly Gln Leu Ser Ser Thr Tyr Ser
145                 150                 155                 160 
Gly Gln His Gln Arg Val Pro His Ala Thr Gly Ala Leu Asn Glu Leu
                165                 170                 175     
Leu Gln Leu Trp Met Gly Cys Arg Ala Thr Arg Thr Leu Met Asp Ile
            180                 185                 190         
Tyr Val Gln Cys Leu Ser Ala Leu Ile Gly Ser Cys Pro Asp Ala Cys
        195                 200                 205             
Val Asp Ala Leu Leu Asp Thr Ser Val Gln His Ser Pro His Phe Asp
    210                 215                 220                 
Trp Val Val Ala His Ile Gly Ser Ser Phe Pro Gly Thr Ile Ile Ser
225                 230                 235                 240 
Arg Val Leu Ser Cys Gly Leu Lys Asp Phe Cys Val His Gly Gly Ala
                245                 250                 255     
Gly Gly Gly Ala Gly Ser Ser Gly Gly Ser Ser Ser Gln Thr Pro Ser
            260                 265                 270         
Thr Asp Pro Phe Pro Gly Ser Pro Ala Ile Pro Ala Glu Lys Arg Val
        275                 280                 285             
Pro Lys Ile Ala Ser Val Val Gly Ile Leu Gly His Leu Ala Ser Arg
    290                 295                 300                 
His Gly Asp Ser Ile Arg Arg Glu Leu Leu Arg Met Phe His Asp Ser
305                 310                 315                 320 
Leu Ala Gly Gly Ser Gly Gly Arg Ser Gly Asp Pro Ser Leu Gln Ala
                325                 330                 335     
Thr Val Pro Phe Leu Leu Gln Leu Ala Val Met Ser Pro Ala Leu Leu
            340                 345                 350         
Gly Thr Val Ser Gly Glu Leu Val Asp Cys Leu Lys Pro Pro Ala Val
        355                 360                 365             
Leu Ser Gln Leu Gln Gln His Leu Gln Gly Phe Pro Arg Glu Glu Leu
    370                 375                 380                 
Asp Asn Met Leu Asn Leu Ala Val His Leu Val Ser Gln Ala Ser Gly
385                 390                 395                 400 
Ala Gly Ala Tyr Arg Leu Leu Gln Phe Leu Val Asp Thr Ala Met Pro
                405                 410                 415     
Ala Ser Val Ile Thr Thr Gln Gly Leu Ala Val Pro Asp Thr Val Arg
            420                 425                 430         
Glu Ala Cys Asp Arg Leu Ile Gln Leu Leu Leu Leu His Leu Gln Lys
        435                 440                 445             
Leu Val His His Arg Gly Gly Ser Pro Gly Glu Gly Val Leu Gly Pro
    450                 455                 460                 
Pro Pro Pro Pro Arg Leu Val Pro Phe Leu Asp Ala Leu Lys Asn His
465                 470                 475                 480 
Val Gly Glu Leu Cys Gly Glu Thr Leu Arg Leu Glu Arg Lys Arg Phe
                485                 490                 495     
Leu Trp Gln His Gln Leu Leu Gly Leu Leu Ser Val Tyr Thr Arg Pro
            500                 505                 510         
Ser Cys Gly Pro Glu Ala Leu Gly His Leu Leu Ser Arg Ala Arg Ser
        515                 520                 525             
Pro Glu Glu Leu Ser Leu Ala Thr Gln Leu Tyr Ala Gly Leu Val Val
    530                 535                 540                 
Ser Leu Ser Gly Leu Leu Pro Leu Ala Phe Arg Ser Cys Leu Ala Arg
545                 550                 555                 560 
Val His Ala Gly Thr Leu Gln Pro Pro Phe Thr Ala Arg Phe Leu Arg
                565                 570                 575     
Asn Leu Ala Leu Leu Val Gly Trp Glu Gln Gln Gly Gly Glu Gly Pro
            580                 585                 590         
Ala Ala Leu Gly Ala His Phe Gly Glu Ser Ala Ser Ala His Leu Ser
        595                 600                 605             
Asp Leu Ala Pro Leu Leu Leu His Pro Glu Glu Glu Val Ala Glu Ala
    610                 615                 620                 
Ala Ala Ser Leu Leu Ala Ile Cys Pro Phe Pro Ser Glu Ala Leu Ser
625                 630                 635                 640 
Pro Ser Gln Leu Leu Gly Leu Val Arg Ala Gly Val His Arg Phe Phe
                645                 650                 655     
Ala Ser Leu Arg Leu His Gly Pro Pro Gly Val Ala Ser Ala Cys Gln
            660                 665                 670         
Leu Leu Thr Arg Leu Ser Gln Thr Ser Pro Ala Gly Leu Lys Ala Val
        675                 680                 685             
Leu Gln Leu Leu Val Glu Gly Ala Leu His Arg Gly Asn Thr Glu Leu
    690                 695                 700                 
Phe Gly Gly Gln Val Asp Gly Asp Asn Glu Thr Leu Ser Val Val Ser
705                 710                 715                 720 
Ala Ser Leu Ala Ser Ala Ser Leu Leu Asp Thr Asn Arg Arg His Thr
                725                 730                 735     
Ala Ala Val Pro Gly Pro Gly Gly Ile Trp Ser Val Phe His Ala Gly
            740                 745                 750         
Val Ile Gly Arg Gly Leu Lys Pro Pro Lys Phe Val Gln Ser Arg Asn
        755                 760                 765             
Gln Gln Glu Val Ile Tyr Asn Thr Gln Ser Leu Leu Ser Leu Leu Val
    770                 775                 780                 
His Cys Cys Ser Ala Pro Gly Gly Thr Glu Cys Gly Glu Cys Trp Gly
785                 790                 795                 800 
Ala Pro Ile Leu Ser Pro Glu Ala Ala Lys Ala Val Ala Val Thr Leu
                805                 810                 815     
Val Glu Ser Val Cys Pro Asp Ala Ala Gly Ala Glu Leu Ala Trp Pro
            820                 825                 830         
Pro Glu Glu His Ala Arg Ala Thr Val Glu Arg Asp Leu Arg Ile Gly
        835                 840                 845             
Arg Arg Phe Arg Glu Gln Pro Leu Leu Phe Glu Leu Leu Lys Leu Val
    850                 855                 860                 
Ala Ala Ala Pro Pro Ala Leu Cys Tyr Cys Ser Val Leu Leu Arg Gly
865                 870                 875                 880 
Leu Leu Ala Ala Leu Leu Gly His Trp Glu Ala Ser Arg His Pro Asp
                885                 890                 895     
Thr Thr His Ser Pro Trp His Leu Glu Ala Ser Cys Thr Leu Val Ala
            900                 905                 910         
Val Met Ala Glu Gly Ser Leu Leu Pro Pro Ala Leu Gly Asn Met His
        915                 920                 925             
Glu Val Phe Ser Gln Leu Ala Pro Phe Glu Val Arg Leu Leu Leu Leu
    930                 935                 940                 
Ser Val Trp Gly Phe Leu Arg Glu His Gly Pro Leu Pro Gln Lys Phe
945                 950                 955                 960 
Ile Phe Gln Ser Glu Arg Gly Arg Phe Ile Arg Asp Phe Ser Arg Glu
                965                 970                 975     
Gly Gly Gly Glu Gly Gly Pro His Leu Ala Val Leu His Ser Val Leu
            980                 985                 990         
His Arg Asn Ile Asp Arg Leu Gly Leu Phe Ser Gly Arg Phe Gln Ala
        995                 1000                1005            
Pro Ser Pro Ser Thr Leu Leu Arg Gln Gly Thr
    1010                1015                


<210> 7525
<211> 919
<212> PRT
<213> Homo sapiens

<400> 7525
Met Lys Phe Ala Tyr Arg Phe Ser Asn Leu Leu Gly Thr Val Tyr Arg
 1               5                  10                  15      
Arg Gly Asn Leu Asn Phe Thr Cys Asn Gly Asn Ser Val Ile Ser Pro
            20                  25                  30          
Val Gly Asn Arg Val Thr Val Phe Asp Leu Lys Asn Asn Lys Ser Asp
        35                  40                  45              
Thr Leu Pro Leu Ala Thr Arg Tyr Asn Val Lys Cys Val Gly Leu Ser
    50                  55                  60                  
Pro Asp Gly Arg Leu Ala Ile Ile Val Asp Glu Gly Gly Asp Ala Leu
65                  70                  75                  80  
Leu Val Ser Leu Val Cys Arg Ser Val Leu His His Phe His Phe Lys
                85                  90                  95      
Gly Ser Val His Ser Val Ser Phe Ser Pro Asp Gly Arg Lys Phe Val
            100                 105                 110         
Val Thr Lys Gly Asn Ile Ala Gln Met Tyr His Ala Pro Gly Lys Lys
        115                 120                 125             
Arg Glu Phe Asn Ala Phe Val Leu Asp Lys Thr Tyr Phe Gly Pro Tyr
    130                 135                 140                 
Asp Glu Thr Thr Cys Ile Asp Trp Thr Asp Asp Ser Arg Cys Phe Val
145                 150                 155                 160 
Val Gly Ser Lys Asp Met Ser Thr Trp Val Phe Gly Ala Glu Arg Trp
                165                 170                 175     
Asp Asn Leu Ile Tyr Tyr Ala Leu Gly Gly His Lys Asp Ala Ile Val
            180                 185                 190         
Ala Cys Phe Phe Glu Ser Asn Ser Leu Asp Leu Tyr Ser Leu Ser Gln
        195                 200                 205             
Asp Gly Val Leu Cys Met Trp Gln Cys Asp Thr Pro Pro Glu Gly Leu
    210                 215                 220                 
Arg Leu Lys Pro Pro Ala Gly Trp Lys Ala Asp Leu Leu Gln Arg Glu
225                 230                 235                 240 
Glu Glu Glu Glu Glu Glu Glu Asp Gln Glu Gly Asp Arg Glu Thr Thr
                245                 250                 255     
Ile Arg Gly Lys Ala Thr Pro Ala Glu Glu Glu Lys Thr Gly Lys Val
            260                 265                 270         
Lys Tyr Ser Arg Leu Ala Lys Tyr Phe Phe Asn Lys Glu Gly Asp Phe
        275                 280                 285             
Asn Asn Leu Thr Ala Ala Ala Phe His Lys Lys Ser His Leu Leu Val
    290                 295                 300                 
Thr Gly Phe Ala Ser Gly Ile Phe His Leu His Glu Leu Pro Glu Phe
305                 310                 315                 320 
Asn Leu Ile His Ser Leu Ser Ile Ser Asp Gln Ser Ile Ala Ser Val
                325                 330                 335     
Ala Ile Asn Ser Ser Gly Asp Trp Ile Ala Phe Gly Cys Ser Gly Leu
            340                 345                 350         
Gly Gln Leu Leu Val Trp Glu Trp Gln Ser Glu Ser Tyr Val Leu Lys
        355                 360                 365             
Gln Gln Gly His Phe Asn Ser Met Val Ala Leu Ala Tyr Ser Pro Asp
    370                 375                 380                 
Gly Gln Tyr Ile Val Thr Gly Gly Asp Asp Gly Lys Val Lys Val Trp
385                 390                 395                 400 
Asn Thr Leu Ser Gly Phe Cys Phe Val Thr Phe Thr Glu His Ser Ser
                405                 410                 415     
Gly Val Thr Gly Val Thr Phe Thr Ala Thr Gly Tyr Val Val Val Thr
            420                 425                 430         
Ser Ser Met Asp Gly Thr Val Arg Ala Phe Asp Leu His Arg Tyr Arg
        435                 440                 445             
Asn Phe Arg Thr Phe Thr Ser Pro Arg Pro Thr Gln Phe Ser Cys Val
    450                 455                 460                 
Ala Val Asp Ala Ser Gly Glu Ile Val Ser Ala Gly Ala Gln Asp Ser
465                 470                 475                 480 
Phe Glu Ile Phe Val Trp Ser Met Gln Thr Gly Arg Leu Leu Asp Val
                485                 490                 495     
Leu Ser Gly His Glu Gly Pro Ile Ser Gly Leu Cys Phe Asn Pro Met
            500                 505                 510         
Lys Ser Val Leu Ala Ser Ala Ser Trp Asp Lys Thr Val Arg Leu Trp
        515                 520                 525             
Asp Met Phe Asp Ser Trp Arg Thr Lys Glu Thr Leu Ala Leu Thr Ser
    530                 535                 540                 
Asp Ala Leu Ala Val Thr Phe Arg Pro Asp Gly Ala Glu Leu Ala Val
545                 550                 555                 560 
Ala Thr Leu Asn Ser Gln Ile Thr Phe Trp Asp Pro Glu Asn Ala Val
                565                 570                 575     
Gln Thr Gly Ser Ile Glu Gly Arg His Asp Leu Lys Thr Gly Arg Lys
            580                 585                 590         
Glu Leu Asp Lys Ile Thr Ala Lys His Ala Ala Lys Gly Lys Ala Phe
        595                 600                 605             
Thr Ala Leu Cys Tyr Ser Ala Asp Gly His Ser Ile Leu Ala Gly Gly
    610                 615                 620                 
Met Ser Lys Phe Val Cys Ile Tyr His Val Arg Glu Gln Ile Leu Met
625                 630                 635                 640 
Lys Arg Phe Glu Ile Ser Cys Asn Leu Ser Leu Asp Ala Met Glu Glu
                645                 650                 655     
Phe Leu Asn Arg Arg Lys Met Thr Glu Phe Gly Asn Leu Ala Leu Ile
            660                 665                 670         
Asp Gln Asp Ala Gly Gln Glu Asp Gly Val Ala Ile Pro Leu Pro Gly
        675                 680                 685             
Val Arg Lys Gly Asp Met Ser Ser Arg His Phe Lys Pro Glu Ile Arg
    690                 695                 700                 
Val Thr Ser Leu Arg Phe Ser Pro Thr Gly Arg Cys Trp Ala Ala Thr
705                 710                 715                 720 
Thr Thr Glu Gly Leu Leu Ile Tyr Ser Leu Asp Thr Arg Val Leu Phe
                725                 730                 735     
Asp Pro Phe Glu Leu Asp Thr Ser Val Thr Pro Gly Arg Val Arg Glu
            740                 745                 750         
Ala Leu Arg Gln Gln Asp Phe Thr Arg Ala Ile Leu Met Ala Leu Arg
        755                 760                 765             
Leu Asn Glu Ser Lys Leu Val Gln Glu Ala Leu Glu Ala Val Pro Arg
    770                 775                 780                 
Gly Glu Ile Glu Val Val Thr Ser Ser Leu Pro Glu Leu Tyr Val Glu
785                 790                 795                 800 
Lys Val Leu Glu Phe Leu Ala Ser Ser Phe Glu Val Ser Arg His Leu
                805                 810                 815     
Glu Phe Tyr Leu Leu Trp Thr His Lys Leu Leu Met Leu His Gly Gln
            820                 825                 830         
Lys Leu Lys Ser Arg Ala Gly Thr Leu Leu Pro Val Ile Gln Phe Leu
        835                 840                 845             
Gln Lys Ser Ile Gln Arg His Leu Asp Asp Leu Ser Lys Leu Cys Ser
    850                 855                 860                 
Trp Asn His Tyr Asn Met Gln Tyr Ala Leu Ala Val Ser Lys Gln Arg
865                 870                 875                 880 
Gly Thr Lys Arg Ser Leu Asp Pro Leu Gly Ser Glu Glu Glu Ala Glu
                885                 890                 895     
Ala Ser Glu Asp Asp Ser Leu His Leu Leu Gly Gly Gly Gly Arg Asp
            900                 905                 910         
Ser Glu Glu Glu Met Leu Ala
        915                 


<210> 7526
<211> 762
<212> PRT
<213> Homo sapiens

<400> 7526
Met Glu Asn Tyr Phe Gln Ala Glu Ala Tyr Asn Leu Asp Lys Val Leu
 1               5                  10                  15      
Asp Glu Phe Glu Gln Asn Glu Asp Glu Thr Val Ser Ser Thr Leu Leu
            20                  25                  30          
Asp Thr Lys Trp Asn Lys Ile Leu Asp Pro Pro Ser His Arg Leu Ser
        35                  40                  45              
Phe Asn Pro Thr Leu Ala Ser Val Asn Glu Ser Ala Val Ser Asn Glu
    50                  55                  60                  
Ser Gln Pro Gln Leu Lys Val Phe Ser Leu Ala His Ser Ala Pro Leu
65                  70                  75                  80  
Thr Thr Glu Glu Glu Asp His Cys Ala Asn Gly Gln Asp Cys Asn Leu
                85                  90                  95      
Asn Pro Glu Ile Ala Thr Met Trp Ile Asp Glu Asn Ala Val Ala Glu
            100                 105                 110         
Asp Gln Leu Ile Lys Arg Asn Tyr Ser Trp Asp Asp Gln Cys Ser Ala
        115                 120                 125             
Val Glu Val Gly Glu Lys Lys Cys Gly Asn Leu Ala Cys Leu Pro Asp
    130                 135                 140                 
Glu Lys Asn Val Leu Val Val Ala Val Met His Asn Cys Asp Lys Arg
145                 150                 155                 160 
Thr Leu Gln Asn Asp Leu Gln Asp Cys Asn Asn Tyr Asn Ser Gln Ser
                165                 170                 175     
Leu Met Asp Ala Phe Ser Cys Ser Leu Asp Asn Glu Asn Arg Gln Thr
            180                 185                 190         
Asp Gln Phe Ser Phe Ser Ile Asn Glu Ser Thr Glu Lys Asp Met Asn
        195                 200                 205             
Ser Glu Lys Gln Met Asp Pro Leu Asn Arg Pro Lys Thr Glu Gly Arg
    210                 215                 220                 
Ser Val Asn His Leu Cys Pro Thr Ser Ser Asp Ser Leu Ala Ser Val
225                 230                 235                 240 
Cys Ser Pro Ser Gln Leu Lys Asp Asp Gly Ser Ile Gly Arg Asp Pro
                245                 250                 255     
Ser Met Ser Ala Ile Thr Ser Leu Thr Val Asp Ser Val Ile Ser Ser
            260                 265                 270         
Gln Gly Thr Asp Gly Cys Pro Ala Val Lys Lys Gln Glu Asn Tyr Ile
        275                 280                 285             
Pro Asp Glu Asp Leu Thr Gly Lys Ile Ser Ser Pro Arg Thr Asp Leu
    290                 295                 300                 
Gly Ser Pro Asn Ser Phe Ser His Met Ser Glu Gly Ile Leu Met Lys
305                 310                 315                 320 
Lys Glu Pro Ala Glu Glu Ser Thr Thr Glu Glu Ser Leu Arg Ser Gly
                325                 330                 335     
Leu Pro Leu Leu Leu Lys Pro Asp Met Pro Asn Gly Ser Gly Arg Asn
            340                 345                 350         
Asn Asp Cys Glu Arg Cys Ser Asp Cys Leu Val Pro Asn Glu Val Arg
        355                 360                 365             
Ala Asp Glu Asn Glu Gly Tyr Glu His Glu Glu Thr Leu Gly Thr Thr
    370                 375                 380                 
Glu Phe Leu Asn Met Thr Glu His Phe Ser Glu Ser Gln Asp Met Thr
385                 390                 395                 400 
Asn Trp Lys Leu Thr Lys Leu Asn Glu Met Asn Asp Ser Gln Val Asn
                405                 410                 415     
Glu Glu Lys Glu Lys Phe Leu Gln Ile Ser Gln Pro Glu Asp Thr Asn
            420                 425                 430         
Gly Asp Ser Gly Gly Gln Cys Val Gly Leu Ala Asp Ala Gly Leu Asp
        435                 440                 445             
Leu Lys Gly Thr Cys Ile Ser Glu Ser Glu Glu Cys Asp Phe Ser Thr
    450                 455                 460                 
Val Ile Asp Thr Pro Ala Ala Asn Tyr Leu Ser Asn Gly Cys Asp Ser
465                 470                 475                 480 
Tyr Gly Met Gln Asp Pro Gly Val Ser Phe Val Pro Lys Thr Leu Pro
                485                 490                 495     
Ser Lys Glu Asp Ser Val Thr Glu Glu Lys Glu Ile Glu Glu Ser Lys
            500                 505                 510         
Ser Glu Cys Tyr Ser Asn Ile Tyr Glu Gln Arg Gly Asn Glu Ala Thr
        515                 520                 525             
Glu Gly Ser Gly Leu Leu Leu Asn Ser Thr Gly Asp Leu Met Lys Lys
    530                 535                 540                 
Asn Tyr Leu His Asn Phe Cys Ser Gln Val Pro Ser Val Leu Gly Gln
545                 550                 555                 560 
Ser Ser Pro Lys Val Val Ala Ser Leu Pro Ser Ile Ser Val Pro Phe
                565                 570                 575     
Gly Gly Ala Arg Pro Lys Gln Pro Ser Asn Leu Lys Leu Gln Ile Pro
            580                 585                 590         
Lys Pro Leu Ser Asp His Leu Gln Asn Asp Phe Pro Ala Asn Ser Gly
        595                 600                 605             
Asn Asn Thr Lys Asn Lys Asn Asp Ile Leu Gly Lys Ala Lys Leu Gly
    610                 615                 620                 
Glu Asn Ser Ala Thr Asn Val Cys Ser Pro Ser Leu Gly Asn Ile Ser
625                 630                 635                 640 
Asn Val Asp Thr Asn Gly Glu His Leu Glu Ser Tyr Glu Ala Glu Ile
                645                 650                 655     
Ser Thr Arg Pro Cys Leu Ala Leu Ala Pro Asp Ser Pro Asp Asn Asp
            660                 665                 670         
Leu Arg Ala Gly Gln Phe Gly Ile Ser Ala Arg Lys Pro Phe Thr Thr
        675                 680                 685             
Leu Gly Glu Val Ala Pro Val Trp Val Pro Asp Ser Gln Ala Pro Asn
    690                 695                 700                 
Cys Met Lys Cys Glu Ala Arg Phe Thr Phe Thr Lys Arg Arg His His
705                 710                 715                 720 
Cys Arg Ala Cys Gly Lys Val Phe Cys Ala Ser Cys Cys Ser Leu Lys
                725                 730                 735     
Cys Lys Leu Leu Tyr Met Asp Arg Lys Glu Ala Arg Val Cys Val Ile
            740                 745                 750         
Cys His Ser Val Leu Met Asn Gly Lys Tyr
        755                 760         


<210> 7527
<211> 1425
<212> PRT
<213> Homo sapiens

<400> 7527
Met Glu Asn Tyr Phe Gln Ala Glu Ala Tyr Asn Leu Asp Lys Val Leu
 1               5                  10                  15      
Asp Glu Phe Glu Gln Asn Glu Asp Glu Thr Val Ser Ser Thr Leu Leu
            20                  25                  30          
Asp Thr Lys Trp Asn Lys Ile Leu Asp Pro Pro Ser His Arg Leu Ser
        35                  40                  45              
Phe Asn Pro Thr Leu Ala Ser Val Asn Glu Ser Ala Val Ser Asn Glu
    50                  55                  60                  
Ser Gln Pro Gln Leu Lys Val Phe Ser Leu Ala His Ser Ala Pro Leu
65                  70                  75                  80  
Thr Thr Glu Glu Glu Asp His Cys Ala Asn Gly Gln Asp Cys Asn Leu
                85                  90                  95      
Asn Pro Glu Ile Ala Thr Met Trp Ile Asp Glu Asn Ala Val Ala Glu
            100                 105                 110         
Asp Gln Leu Ile Lys Arg Asn Tyr Ser Trp Asp Asp Gln Cys Ser Ala
        115                 120                 125             
Val Glu Val Gly Glu Lys Lys Cys Gly Asn Leu Ala Cys Leu Pro Asp
    130                 135                 140                 
Glu Lys Asn Val Leu Val Val Ala Val Met His Asn Cys Asp Lys Arg
145                 150                 155                 160 
Thr Leu Gln Asn Asp Leu Gln Asp Cys Asn Asn Tyr Asn Ser Gln Ser
                165                 170                 175     
Leu Met Asp Ala Phe Ser Cys Ser Leu Asp Asn Glu Asn Arg Gln Thr
            180                 185                 190         
Asp Gln Phe Ser Phe Ser Ile Asn Glu Ser Thr Glu Lys Asp Met Asn
        195                 200                 205             
Ser Glu Lys Gln Met Asp Pro Leu Asn Arg Pro Lys Thr Glu Gly Arg
    210                 215                 220                 
Ser Val Asn His Leu Cys Pro Thr Ser Ser Asp Ser Leu Ala Ser Val
225                 230                 235                 240 
Cys Ser Pro Ser Gln Leu Lys Asp Asp Gly Ser Ile Gly Arg Asp Pro
                245                 250                 255     
Ser Met Ser Ala Ile Thr Ser Leu Thr Val Asp Ser Val Ile Ser Ser
            260                 265                 270         
Gln Gly Thr Asp Gly Cys Pro Ala Val Lys Lys Gln Glu Asn Tyr Ile
        275                 280                 285             
Pro Asp Glu Asp Leu Thr Gly Lys Ile Ser Ser Pro Arg Thr Asp Leu
    290                 295                 300                 
Gly Ser Pro Asn Ser Phe Ser His Met Ser Glu Gly Ile Leu Met Lys
305                 310                 315                 320 
Lys Glu Pro Ala Glu Glu Ser Thr Thr Glu Glu Ser Leu Arg Ser Gly
                325                 330                 335     
Leu Pro Leu Leu Leu Lys Pro Asp Met Pro Asn Gly Ser Gly Arg Asn
            340                 345                 350         
Asn Asp Cys Glu Arg Cys Ser Asp Cys Leu Val Pro Asn Glu Val Arg
        355                 360                 365             
Ala Asp Glu Asn Glu Gly Tyr Glu His Glu Glu Thr Leu Gly Thr Thr
    370                 375                 380                 
Glu Phe Leu Asn Met Thr Glu His Phe Ser Glu Ser Gln Asp Met Thr
385                 390                 395                 400 
Asn Trp Lys Leu Thr Lys Leu Asn Glu Met Asn Asp Ser Gln Val Asn
                405                 410                 415     
Glu Glu Lys Glu Lys Phe Leu Gln Ile Ser Gln Pro Glu Asp Thr Asn
            420                 425                 430         
Gly Asp Ser Gly Gly Gln Cys Val Gly Leu Ala Asp Ala Gly Leu Asp
        435                 440                 445             
Leu Lys Gly Thr Cys Ile Ser Glu Ser Glu Glu Cys Asp Phe Ser Thr
    450                 455                 460                 
Val Ile Asp Thr Pro Ala Ala Asn Tyr Leu Ser Asn Gly Cys Asp Ser
465                 470                 475                 480 
Tyr Gly Met Gln Asp Pro Gly Val Ser Phe Val Pro Lys Thr Leu Pro
                485                 490                 495     
Ser Lys Glu Asp Ser Val Thr Glu Glu Lys Glu Ile Glu Glu Ser Lys
            500                 505                 510         
Ser Glu Cys Tyr Ser Asn Ile Tyr Glu Gln Arg Gly Asn Glu Ala Thr
        515                 520                 525             
Glu Gly Ser Gly Leu Leu Leu Asn Ser Thr Gly Asp Leu Met Lys Lys
    530                 535                 540                 
Asn Tyr Leu His Asn Phe Cys Ser Gln Val Pro Ser Val Leu Gly Gln
545                 550                 555                 560 
Ser Ser Pro Lys Val Val Ala Ser Leu Pro Ser Ile Ser Val Pro Phe
                565                 570                 575     
Gly Gly Ala Arg Pro Lys Gln Pro Ser Asn Leu Lys Leu Gln Ile Pro
            580                 585                 590         
Lys Pro Leu Ser Asp His Leu Gln Asn Asp Phe Pro Ala Asn Ser Gly
        595                 600                 605             
Asn Asn Thr Lys Asn Lys Asn Asp Ile Leu Gly Lys Ala Lys Leu Gly
    610                 615                 620                 
Glu Asn Ser Ala Thr Asn Val Cys Ser Pro Ser Leu Gly Asn Ile Ser
625                 630                 635                 640 
Asn Val Asp Thr Asn Gly Glu His Leu Glu Ser Tyr Glu Ala Glu Ile
                645                 650                 655     
Ser Thr Arg Pro Cys Leu Ala Leu Ala Pro Asp Ser Pro Asp Asn Asp
            660                 665                 670         
Leu Arg Ala Gly Gln Phe Gly Ile Ser Ala Arg Lys Pro Phe Thr Thr
        675                 680                 685             
Leu Gly Glu Val Ala Pro Val Trp Val Pro Asp Ser Gln Ala Pro Asn
    690                 695                 700                 
Cys Met Lys Cys Glu Ala Arg Phe Thr Phe Thr Lys Arg Arg His His
705                 710                 715                 720 
Cys Arg Ala Cys Gly Lys Val Phe Cys Ala Ser Cys Cys Ser Leu Lys
                725                 730                 735     
Cys Lys Leu Leu Tyr Met Asp Arg Lys Glu Ala Arg Val Cys Val Ile
            740                 745                 750         
Cys His Ser Val Leu Met Asn Ala Gln Ala Trp Glu Asn Met Met Ser
        755                 760                 765             
Ala Ser Ser Gln Ser Pro Asn Pro Asn Asn Pro Ala Glu Tyr Cys Ser
    770                 775                 780                 
Thr Ile Pro Pro Leu Gln Gln Ala Gln Ala Ser Gly Ala Leu Ser Ser
785                 790                 795                 800 
Pro Pro Pro Thr Val Met Val Pro Val Gly Val Leu Lys His Pro Gly
                805                 810                 815     
Ala Glu Val Ala Gln Pro Arg Glu Gln Arg Arg Val Trp Phe Ala Asp
            820                 825                 830         
Gly Ile Leu Pro Asn Gly Glu Val Ala Asp Ala Ala Lys Leu Thr Met
        835                 840                 845             
Asn Gly Thr Ser Ser Ala Gly Thr Leu Ala Val Ser His Asp Pro Val
    850                 855                 860                 
Lys Pro Val Thr Thr Ser Pro Leu Pro Ala Glu Thr Asp Ile Cys Leu
865                 870                 875                 880 
Phe Ser Gly Ser Ile Thr Gln Val Gly Ser Pro Val Gly Ser Ala Met
                885                 890                 895     
Asn Leu Ile Pro Glu Asp Gly Leu Pro Pro Ile Leu Ile Ser Thr Gly
            900                 905                 910         
Val Lys Gly Asp Tyr Ala Val Glu Glu Lys Pro Ser Gln Ile Ser Val
        915                 920                 925             
Met Gln Gln Leu Glu Asp Gly Gly Pro Asp Pro Leu Val Phe Val Leu
    930                 935                 940                 
Asn Ala Asn Leu Leu Ser Met Val Lys Ile Val Asn Tyr Val Asn Arg
945                 950                 955                 960 
Lys Cys Trp Cys Phe Thr Thr Lys Gly Met His Ala Val Gly Gln Ser
                965                 970                 975     
Glu Ile Val Ile Leu Leu Gln Cys Leu Pro Asp Glu Lys Cys Leu Pro
            980                 985                 990         
Lys Asp Ile Phe Asn His Phe Val Gln Leu Tyr Arg Asp Ala Leu Ala
        995                 1000                1005            
Gly Asn Val Val Ser Asn Leu Gly His Ser Phe Phe Ser Gln Ser Phe
    1010                1015                1020                
Leu Gly Ser Lys Glu His Gly Gly Phe Leu Tyr Val Thr Ser Thr Tyr
1025                1030                1035                1040
Gln Ser Leu Gln Asp Leu Val Leu Pro Thr Pro Pro Tyr Leu Phe Gly
                1045                1050                1055    
Ile Leu Ile Gln Lys Trp Glu Thr Pro Trp Ala Lys Val Phe Pro Ile
            1060                1065                1070        
Arg Leu Met Leu Arg Leu Gly Ala Glu Tyr Arg Leu Tyr Pro Cys Pro
        1075                1080                1085            
Leu Phe Ser Val Arg Phe Arg Lys Pro Leu Phe Gly Glu Thr Gly His
    1090                1095                1100                
Thr Ile Met Asn Leu Leu Ala Asp Phe Arg Asn Tyr Gln Tyr Thr Leu
1105                1110                1115                1120
Pro Val Val Gln Gly Leu Val Val Asp Met Glu Val Arg Lys Thr Ser
                1125                1130                1135    
Ile Lys Ile Pro Ser Asn Arg Tyr Asn Glu Met Met Lys Ala Met Asn
            1140                1145                1150        
Lys Ser Asn Glu His Val Leu Ala Gly Gly Ala Cys Phe Asn Glu Lys
        1155                1160                1165            
Ala Asp Ser His Leu Val Cys Val Gln Asn Asp Asp Gly Asn Tyr Gln
    1170                1175                1180                
Thr Gln Ala Ile Ser Ile His Asn Gln Pro Arg Lys Val Thr Gly Ala
1185                1190                1195                1200
Ser Phe Phe Val Phe Ser Gly Ala Leu Lys Ser Ser Ser Gly Tyr Leu
                1205                1210                1215    
Ala Lys Ser Ser Ile Val Glu Asp Gly Val Met Val Gln Ile Thr Ala
            1220                1225                1230        
Glu Asn Met Asp Ser Leu Arg Gln Ala Leu Arg Glu Met Lys Asp Phe
        1235                1240                1245            
Thr Ile Thr Cys Gly Lys Ala Asp Ala Glu Glu Pro Gln Glu His Ile
    1250                1255                1260                
His Ile Gln Trp Val Asp Asp Asp Lys Asn Val Ser Lys Gly Val Val
1265                1270                1275                1280
Ser Pro Ile Asp Gly Lys Ser Met Glu Thr Ile Thr Asn Val Lys Ile
                1285                1290                1295    
Phe His Gly Ser Glu Tyr Lys Ala Asn Gly Lys Val Ile Arg Trp Thr
            1300                1305                1310        
Glu Val Phe Phe Leu Glu Asn Asp Asp Gln His Asn Cys Leu Ser Asp
        1315                1320                1325            
Pro Ala Asp His Ser Arg Leu Thr Glu His Val Ala Lys Ala Phe Cys
    1330                1335                1340                
Leu Ala Leu Cys Pro His Leu Lys Leu Leu Lys Glu Asp Gly Met Thr
1345                1350                1355                1360
Lys Leu Gly Leu Arg Val Thr Leu Asp Ser Asp Gln Val Gly Tyr Gln
                1365                1370                1375    
Ala Gly Ser Asn Gly Gln Pro Leu Pro Ser Gln Tyr Met Asn Asp Leu
            1380                1385                1390        
Asp Ser Ala Leu Val Pro Val Ile His Gly Gly Ala Cys Gln Leu Ser
        1395                1400                1405            
Glu Gly Pro Val Val Met Glu Leu Ile Phe Tyr Ile Leu Glu Asn Ile
    1410                1415                1420                
Val
1425


<210> 7528
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 7528
Met Glu Asn Tyr Phe Gln Ala Glu Ala Tyr Asn Leu Asp Lys Val Leu
 1               5                  10                  15      
Asp Glu Phe Glu Gln Asn Glu Asp Glu Thr Val Ser Ser Thr Leu Leu
            20                  25                  30          
Asp Thr Lys Trp Asn Lys Ile Leu Asp Pro Pro Ser His Arg Leu Ser
        35                  40                  45              
Phe Asn Pro Thr Leu Ala Ser Val Asn Glu Ser Ala Val Ser Asn Glu
    50                  55                  60                  
Ser Gln Pro Gln Leu Lys Val Phe Ser Leu Ala His Ser Ala Pro Leu
65                  70                  75                  80  
Thr Thr Glu Glu Glu Asp His Cys Ala Asn Gly Gln Asp Cys Asn Leu
                85                  90                  95      
Asn Pro Glu Ile Ala Thr Met Trp Ile Asp Glu Asn Ala Val Ala Glu
            100                 105                 110         
Asp Gln Leu Ile Lys Arg Asn Tyr Ser Trp Asp Asp Gln Cys Ser Ala
        115                 120                 125             
Val Glu Val Gly Glu Lys Lys Cys Gly Asn Leu Ala Cys Leu Pro Asp
    130                 135                 140                 
Glu Lys Asn Val Leu Val Val Ala Val Met His Asn Cys Asp Lys Arg
145                 150                 155                 160 
Thr Leu Gln Asn Asp Leu Gln Asp Cys Asn Asn Tyr Asn Ser Gln Ser
                165                 170                 175     
Leu Met Asp Ala Phe Ser Cys Ser Leu Asp Asn Glu Asn Arg Gln Thr
            180                 185                 190         
Asp Gln Phe Ser Phe Ser Ile Asn Glu Ser Thr Glu Lys Asp Met Asn
        195                 200                 205             
Ser Glu Lys Gln Met Asp Pro Leu Asn Arg Pro Lys Thr Glu Gly Arg
    210                 215                 220                 
Ser Val Asn His Leu Cys Pro Thr Ser Ser Asp Ser Leu Ala Ser Val
225                 230                 235                 240 
Cys Ser Pro Ser Gln Leu Lys Asp Asp Gly Ser Ile Gly Arg Asp Pro
                245                 250                 255     
Ser Met Ser Ala Ile Thr Ser Leu Thr Val Asp Ser Val Ile Ser Ser
            260                 265                 270         
Gln Gly Thr Asp Gly Cys Pro Ala Val Lys Lys Gln Glu Asn Tyr Ile
        275                 280                 285             
Pro Asp Glu Asp Leu Thr Gly Lys Ile Ser Ser Pro Arg Thr Asp Leu
    290                 295                 300                 
Gly Ser Pro Asn Ser Phe Ser His Met Ser Glu Gly Ile Leu Met Lys
305                 310                 315                 320 
Lys Glu Pro Ala Glu Glu Ser Thr Thr Glu Glu Ser Leu Arg Ser Gly
                325                 330                 335     
Leu Pro Leu Leu Leu Lys Pro Asp Met Pro Asn Gly Ser Gly Arg Asn
            340                 345                 350         
Asn Asp Cys Glu Arg Cys Ser Asp Cys Leu Val Pro Asn Glu Val Arg
        355                 360                 365             
Ala Asp Glu Asn Glu Gly Tyr Glu His Glu Glu Thr Leu Gly Thr Thr
    370                 375                 380                 
Glu Phe Leu Asn Met Thr Glu His Phe Ser Glu Ser Gln Asp Met Thr
385                 390                 395                 400 
Asn Trp Lys Leu Thr Lys Leu Asn Glu Met Asn Asp Ser Gln Val Asn
                405                 410                 415     
Glu Glu Lys Glu Lys Phe Leu Gln Ile Ser Gln Pro Glu Asp Thr Asn
            420                 425                 430         
Gly Asp Ser Gly Gly Gln Cys Val Gly Leu Ala Asp Ala Gly Leu Asp
        435                 440                 445             
Leu Lys Gly Thr Cys Ile Ser Glu Ser Glu Glu Cys Asp Phe Ser Thr
    450                 455                 460                 
Val Ile Asp Thr Pro Ala Ala Asn Tyr Leu Ser Asn Gly Cys Asp Ser
465                 470                 475                 480 
Tyr Gly Met Gln Asp Pro Gly Val Ser Phe Val Pro Lys Thr Leu Pro
                485                 490                 495     
Ser Lys Glu Asp Ser Val Thr Glu Glu Lys Glu Ile Glu Glu Ser Lys
            500                 505                 510         
Ser Glu Cys Tyr Ser Asn Ile Tyr Glu Gln Arg Gly Asn Glu Ala Thr
        515                 520                 525             
Glu Gly Ser Gly Leu Leu Leu Asn Ser Thr Gly Asp Leu Met Lys Lys
    530                 535                 540                 
Asn Tyr Leu His Asn Phe Cys Ser Gln Val Pro Ser Val Leu Gly Gln
545                 550                 555                 560 
Ser Ser Pro Lys Val Val Ala Ser Leu Pro Ser Ile Ser Val Pro Phe
                565                 570                 575     
Gly Gly Ala Arg Pro Lys Gln Pro Ser Asn Leu Lys Leu Gln Ile Pro
            580                 585                 590         
Lys Pro Leu Ser Asp His Leu Gln Asn Asp Phe Pro Ala Asn Ser Gly
        595                 600                 605             
Asn Asn Thr Lys Asn Lys Asn Asp Ile Leu Gly Lys Ala Lys Leu Gly
    610                 615                 620                 
Glu Asn Ser Ala Thr Asn Val Cys Ser Pro Ser Leu Gly Asn Ile Ser
625                 630                 635                 640 
Asn Val Asp Thr Asn Gly Glu His Leu Glu Ser Tyr Glu Ala Glu Ile
                645                 650                 655     
Ser Thr Arg Pro Cys Leu Ala Leu Ala Pro Asp Ser Pro Asp Asn Asp
            660                 665                 670         
Leu Arg Ala Gly Gln Phe Gly Ile Ser Ala Arg Lys Pro Phe Thr Thr
        675                 680                 685             
Leu Gly Glu Val Ala Pro Val Trp Val Pro Asp Ser Gln Ala Pro Asn
    690                 695                 700                 
Cys Met Lys Cys Glu Ala Arg Phe Thr Phe Thr Lys Arg Arg His His
705                 710                 715                 720 
Cys Arg Ala Cys Gly Lys Val Phe Cys Ala Ser Cys Cys Ser Leu Lys
                725                 730                 735     
Cys Lys Leu Leu Tyr Met Asp Arg Lys Glu Ala Arg Val Cys Val Ile
            740                 745                 750         
Cys His Ser Val Leu Met Asn Val Ala Gln Pro Arg Glu Gln Arg Arg
        755                 760                 765             
Val Trp Phe Ala Asp Gly Ile Leu Pro Asn Gly Glu Val Ala Asp Ala
    770                 775                 780                 
Ala Lys Leu Thr Met Asn Gly Thr Ser Ser Ala Gly Thr Leu Ala Val
785                 790                 795                 800 
Ser His Asp Pro Val Lys Pro Val Thr Thr Ser Pro Leu Pro Ala Glu
                805                 810                 815     
Thr Asp Ile Cys Leu Phe Ser Gly Ser Ile Thr Gln Val Gly Ser Pro
            820                 825                 830         
Val Gly Ser Ala Met Asn Leu Ile Pro Glu Asp Gly Leu Pro Pro Ile
        835                 840                 845             
Leu Ile Ser Thr Gly Val Lys Gly Asp Tyr Ala Val Glu Glu Lys Pro
    850                 855                 860                 
Ser Gln Ile Ser Val Met Gln Gln Leu Glu Asp Gly Gly Pro Asp Pro
865                 870                 875                 880 
Leu Val Phe Val Leu Asn Ala Asn Leu Leu Ser Met Val Lys Ile Val
                885                 890                 895     
Asn Tyr Val Asn Arg Lys Cys Trp Cys Phe Thr Thr Lys Gly Met His
            900                 905                 910         
Ala Val Gly Gln Ser Glu Ile Val Ile Leu Leu Gln Cys Leu Pro Asp
        915                 920                 925             
Glu Lys Cys Leu Pro Lys Asp Ile Phe Asn His Phe Val Gln Leu Tyr
    930                 935                 940                 
Arg Asp Ala Leu Ala Gly Asn Val Val Ser Asn Leu Gly His Ser Phe
945                 950                 955                 960 
Phe Ser Gln Ser Phe Leu Gly Ser Lys Glu His Gly Gly Phe Leu Tyr
                965                 970                 975     
Val Thr Ser Thr Tyr Gln Ser Leu Gln Asp Leu Val Leu Pro Thr Pro
            980                 985                 990         
Pro Tyr Leu Phe Gly Ile Leu Ile Gln Lys Trp Glu Thr Pro Trp Ala
        995                 1000                1005            
Lys Val Phe Pro Ile Arg Leu Met Leu Arg Leu Gly Ala Glu Tyr Arg
    1010                1015                1020                
Leu Tyr Pro Cys Pro Leu Phe Ser Val Arg Phe Arg Lys Pro Leu Phe
1025                1030                1035                1040
Gly Glu Thr Gly His Thr Ile Met Asn Leu Leu Ala Asp Phe Arg Asn
                1045                1050                1055    
Tyr Gln Tyr Thr Leu Pro Val Val Gln Gly Leu Val Val Asp Met Glu
            1060                1065                1070        
Val Arg Lys Thr Ser Ile Lys Ile Pro Ser Asn Arg Tyr Asn Glu Met
        1075                1080                1085            
Met Lys Ala Met Asn Lys Ser Asn Glu His Val Leu Ala Gly Gly Ala
    1090                1095                1100                
Cys Phe Asn Glu Lys Ala Asp Ser His Leu Val Cys Val Gln Asn Asp
1105                1110                1115                1120
Asp Gly Asn Tyr Gln Thr Gln Ala Ile Ser Ile His Asn Gln Pro Arg
                1125                1130                1135    
Lys Val Thr Gly Ala Ser Phe Phe Val Phe Ser Gly Ala Leu Lys Ser
            1140                1145                1150        
Ser Ser Gly Tyr Leu Ala Lys Ser Ser Ile Val Glu Asp Gly Val Met
        1155                1160                1165            
Val Gln Ile Thr Ala Glu Asn Met Asp Ser Leu Arg Gln Ala Leu Arg
    1170                1175                1180                
Asp Glu Gly Leu His His His Leu Trp Glu Gly Gly Arg Gly Gly Thr
1185                1190                1195                1200
Pro Gly Ala His Pro His Pro Val Gly Gly
                1205                1210


<210> 7529
<211> 116
<212> PRT
<213> Homo sapiens

<400> 7529
Met Cys His Pro Glu Ala Ser Arg Pro Phe Ser Pro Trp Tyr Pro Pro
 1               5                  10                  15      
Pro Arg Ser Cys Leu Pro Lys Pro Ser Ser Cys Cys Cys Ser His Asn
            20                  25                  30          
Lys Cys His His Gln Gly Pro Ser Ser Cys Gln Cys Arg Leu Ser Arg
        35                  40                  45              
Ala Gly Asp Trp Gly Thr Cys Ser His His Leu Ser Asn Ser Gly Gly
    50                  55                  60                  
Ser Gln Ala Ser Gln Gly Ser Asp Asp Asp Arg Asn Glu Lys Trp Asp
65                  70                  75                  80  
Asp Ser Ser Thr Leu Val Asp Glu Leu Arg Thr Pro Gly Arg Gly Met
                85                  90                  95      
Tyr Leu Val Phe Asp Gly Ser Val Asp Leu His Tyr Asn Cys Ser Ala
            100                 105                 110         
Lys Cys Lys Ser
        115     


<210> 7530
<211> 318
<212> PRT
<213> Homo sapiens

<400> 7530
Met Phe Ala Lys Gly Arg Gly Ser Ala Val Pro Ser Asp Gly Gln Ala
 1               5                  10                  15      
Trp Glu Lys Leu Ala Ser Tyr Val Tyr Glu Tyr Leu Leu His Val Arg
            20                  25                  30          
Val Gln Lys Ser Ala Glu Thr Phe Leu Ser Glu Ile Arg Trp Glu Lys
        35                  40                  45              
Asn Ile Thr Leu Gly Glu Pro Pro Gly Phe Leu His Ser Trp Trp Cys
    50                  55                  60                  
Val Phe Gly Asp Leu Tyr Cys Ala Ala Pro Gln Arg Arg Asp Thr Cys
65                  70                  75                  80  
Glu His Ser Ser Glu Ala Lys Ala Phe His Asp Tyr Ser Ala Ala Ala
                85                  90                  95      
Ala Pro Ser Pro Val Leu Gly Asn Ile Pro Pro Asn Asp Gly Met Pro
            100                 105                 110         
Gly Gly Pro Ile Pro Pro Gly Phe Phe Gln Gly Pro Pro Gly Ser Gln
        115                 120                 125             
Pro Ser Pro His Ala Gln Pro Pro Pro His Asn Pro Ser Ser Met Met
    130                 135                 140                 
Gly Pro His Ser Gln Pro Phe Met Ser Pro Arg Tyr Val Gly Gly Pro
145                 150                 155                 160 
Gly Pro Pro Ile Arg Met Gly Asn Gln Pro Pro Gly Gly Val Leu Gly
                165                 170                 175     
Thr Gln Pro Leu Leu Pro Asn Ser Met Asp Pro Thr Arg Gln Gln Gly
            180                 185                 190         
His Pro Asn Met Gly Gly Ser Met Gln Arg Met Asn Pro Pro Arg Gly
        195                 200                 205             
Met Gly Pro Met Gly Thr Pro Ile Met Pro Ser Pro Ala Asp Ser Thr
    210                 215                 220                 
Asn Ser Ser Asp Asn Ile Tyr Thr Met Thr Gly Gly Arg Ser Asn Phe
225                 230                 235                 240 
Pro Met Gly Pro Gly Ser Asp Gly Pro Met Gly Gly Met Gly Gly Met
                245                 250                 255     
Glu Pro His His Met Asn Gly Ser Leu Gly Ser Gly Asp Ile Asp Gly
            260                 265                 270         
Leu Pro Lys Asn Ser Pro Asn Asn Ile Ser Gly Ile Ser Asn Pro Pro
        275                 280                 285             
Gly Thr Pro Arg Asp Asp Gly Glu Leu Gly Gly Ser Phe Leu His Ser
    290                 295                 300                 
Phe Gln Asn Asp Asn Tyr Ser Pro Ser Met Thr Met Ser Val
305                 310                 315             


<210> 7531
<211> 412
<212> PRT
<213> Homo sapiens

<400> 7531
Met Ile Ser Phe Cys Pro Asp Cys Gly Lys Ser Ile Gln Ala Ala Phe
 1               5                  10                  15      
Lys Phe Cys Pro Tyr Cys Gly Asn Ser Leu Pro Val Glu Glu His Val
            20                  25                  30          
Gly Ser Gln Thr Phe Val Asn Pro His Val Ser Ser Phe Gln Gly Ser
        35                  40                  45              
Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys
    50                  55                  60                  
Trp Ser Ser Thr Val Thr Ser Pro Arg Leu Ser Leu Phe Ser Asp Gly
65                  70                  75                  80  
Asp Ser Ser Glu Ser Glu Asp Thr Leu Ser Ser Ser Glu Arg Ser Lys
                85                  90                  95      
Gly Ser Gly Ser Arg Pro Pro Thr Pro Lys Ser Ser Pro Gln Lys Thr
            100                 105                 110         
Arg Lys Ser Pro Gln Val Thr Arg Gly Ser Pro Gln Lys Thr Ser Cys
        115                 120                 125             
Ser Pro Gln Lys Thr Arg Gln Ser Pro Gln Thr Leu Lys Arg Ser Arg
    130                 135                 140                 
Val Thr Thr Ser Leu Glu Ala Leu Pro Thr Gly Thr Val Leu Thr Asp
145                 150                 155                 160 
Lys Ser Gly Arg Gln Trp Lys Leu Lys Ser Phe Gln Thr Arg Asp Asn
                165                 170                 175     
Gln Gly Ile Leu Tyr Glu Ala Ala Pro Thr Ser Thr Leu Thr Cys Asp
            180                 185                 190         
Ser Gly Pro Gln Lys Gln Lys Phe Ser Leu Lys Leu Asp Ala Lys Asp
        195                 200                 205             
Gly Arg Leu Phe Asn Glu Gln Asn Phe Phe Gln Arg Ala Ala Lys Pro
    210                 215                 220                 
Leu Gln Val Asn Lys Trp Lys Lys Leu Tyr Ser Thr Pro Leu Leu Ala
225                 230                 235                 240 
Ile Pro Thr Cys Met Gly Phe Gly Val His Gln Asp Lys Tyr Arg Phe
                245                 250                 255     
Leu Val Leu Pro Ser Leu Gly Arg Ser Leu Gln Ser Ala Leu Asp Val
            260                 265                 270         
Ser Pro Lys His Val Leu Ser Glu Arg Ser Val Leu Gln Val Ala Cys
        275                 280                 285             
Arg Leu Leu Asp Ala Leu Glu Phe Leu His Glu Asn Glu Tyr Val His
    290                 295                 300                 
Gly Asn Val Thr Ala Glu Asn Ile Phe Val Asp Pro Glu Asp Gln Ser
305                 310                 315                 320 
Gln Val Thr Leu Ala Gly Tyr Gly Phe Ala Phe Arg Tyr Cys Pro Ser
                325                 330                 335     
Gly Lys His Val Ala Tyr Val Glu Gly Ser Arg Ser Pro His Glu Gly
            340                 345                 350         
Asp Leu Glu Phe Ile Ser Met Asp Leu His Lys Gly Cys Gly Pro Ser
        355                 360                 365             
Arg Arg Ser Asp Leu Gln Ser Leu Gly Tyr Cys Met Leu Lys Trp Leu
    370                 375                 380                 
Tyr Gly Phe Leu Pro Trp Thr Asn Cys Leu Pro Asn Thr Glu Asp Ile
385                 390                 395                 400 
Met Lys Gln Lys Gln Lys Leu Pro Trp Asp Ser Phe
                405                 410         


<210> 7532
<211> 474
<212> PRT
<213> Homo sapiens

<400> 7532
Met Ile Ser Phe Cys Pro Asp Cys Gly Lys Ser Ile Gln Ala Ala Phe
 1               5                  10                  15      
Lys Phe Cys Pro Tyr Cys Gly Asn Ser Leu Pro Val Glu Glu His Val
            20                  25                  30          
Gly Ser Gln Thr Phe Val Asn Pro His Val Ser Ser Phe Gln Gly Ser
        35                  40                  45              
Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys
    50                  55                  60                  
Trp Ser Ser Thr Val Thr Ser Pro Arg Leu Ser Leu Phe Ser Asp Gly
65                  70                  75                  80  
Asp Ser Ser Glu Ser Glu Asp Thr Leu Ser Ser Ser Glu Arg Ser Lys
                85                  90                  95      
Gly Ser Gly Ser Arg Pro Pro Thr Pro Lys Ser Ser Pro Gln Lys Thr
            100                 105                 110         
Arg Lys Ser Pro Gln Val Thr Arg Gly Ser Pro Gln Lys Thr Ser Cys
        115                 120                 125             
Ser Pro Gln Lys Thr Arg Gln Ser Pro Gln Thr Leu Lys Arg Ser Arg
    130                 135                 140                 
Val Thr Thr Ser Leu Glu Ala Leu Pro Thr Gly Thr Val Leu Thr Asp
145                 150                 155                 160 
Lys Ser Gly Arg Gln Trp Lys Leu Lys Ser Phe Gln Thr Arg Asp Asn
                165                 170                 175     
Gln Gly Ile Leu Tyr Glu Ala Ala Pro Thr Ser Thr Leu Thr Cys Asp
            180                 185                 190         
Ser Gly Pro Gln Lys Gln Lys Phe Ser Leu Lys Leu Asp Ala Lys Asp
        195                 200                 205             
Gly Arg Leu Phe Asn Glu Gln Asn Phe Phe Gln Arg Ala Ala Lys Pro
    210                 215                 220                 
Leu Gln Val Asn Lys Trp Lys Lys Leu Tyr Ser Thr Pro Leu Leu Ala
225                 230                 235                 240 
Ile Pro Thr Cys Met Gly Phe Gly Val His Gln Asp Lys Tyr Arg Phe
                245                 250                 255     
Leu Val Leu Pro Ser Leu Gly Arg Ser Leu Gln Ser Ala Leu Asp Val
            260                 265                 270         
Ser Pro Lys His Val Leu Ser Glu Arg Ser Val Leu Gln Val Ala Cys
        275                 280                 285             
Arg Leu Leu Asp Ala Leu Glu Phe Leu His Glu Asn Glu Tyr Val His
    290                 295                 300                 
Gly Asn Val Thr Ala Glu Asn Ile Phe Val Asp Pro Glu Asp Gln Ser
305                 310                 315                 320 
Gln Val Thr Leu Ala Gly Tyr Gly Phe Ala Phe Arg Tyr Cys Pro Ser
                325                 330                 335     
Gly Lys His Val Ala Tyr Val Glu Gly Ser Arg Ser Pro His Glu Gly
            340                 345                 350         
Asp Leu Glu Phe Ile Ser Met Asp Leu His Lys Gly Cys Gly Pro Ser
        355                 360                 365             
Arg Arg Ser Asp Leu Gln Ser Leu Gly Tyr Cys Met Leu Lys Trp Leu
    370                 375                 380                 
Tyr Gly Phe Leu Pro Trp Thr Asn Cys Leu Pro Asn Thr Glu Asp Ile
385                 390                 395                 400 
Met Lys Gln Lys Gln Lys Phe Val Asp Lys Pro Gly Pro Phe Val Gly
                405                 410                 415     
Pro Cys Gly His Trp Ile Arg Pro Ser Glu Thr Leu Gln Lys Tyr Leu
            420                 425                 430         
Lys Val Val Met Ala Leu Thr Tyr Glu Glu Lys Pro Pro Tyr Ala Met
        435                 440                 445             
Leu Arg Asn Asn Leu Glu Ala Leu Leu Gln Asp Leu Arg Val Ser Pro
    450                 455                 460                 
Tyr Asp Pro Ile Gly Leu Pro Met Val Pro
465                 470                 


<210> 7533
<211> 350
<212> PRT
<213> Homo sapiens

<400> 7533
Met Pro Gly Pro Ala Ala Gly Ser Arg Ala Arg Val Tyr Ala Glu Val
 1               5                  10                  15      
Asn Ser Leu Arg Ser Arg Glu Tyr Trp Asp Tyr Glu Ala His Val Pro
            20                  25                  30          
Ser Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg
        35                  40                  45              
Gly Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu
    50                  55                  60                  
Arg Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys
65                  70                  75                  80  
Arg Glu Val Lys Ile Leu Glu Asn Leu Arg Gly Gly Thr Asn Ile Ile
                85                  90                  95      
Lys Leu Ile Asp Thr Val Lys Asp Pro Val Ser Lys Thr Pro Ala Leu
            100                 105                 110         
Val Phe Glu Tyr Ile Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Ile
        115                 120                 125             
Leu Thr Asp Phe Asp Ile Arg Phe Tyr Met Tyr Glu Leu Leu Lys Ala
    130                 135                 140                 
Leu Asp Tyr Cys His Ser Lys Gly Ile Met His Arg Asp Val Lys Pro
145                 150                 155                 160 
His Asn Val Met Ile Asp His Gln Gln Lys Lys Leu Arg Leu Ile Asp
                165                 170                 175     
Trp Gly Leu Ala Glu Phe Tyr His Pro Ala Gln Glu Tyr Asn Val Arg
            180                 185                 190         
Val Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln
        195                 200                 205             
Met Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala
    210                 215                 220                 
Ser Met Ile Phe Arg Arg Glu Pro Phe Phe His Gly Gln Asp Asn Tyr
225                 230                 235                 240 
Asp Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Glu Leu Tyr
                245                 250                 255     
Gly Tyr Leu Lys Lys Tyr His Ile Asp Leu Asp Pro His Phe Asn Asp
            260                 265                 270         
Ile Leu Gly Gln His Ser Arg Lys Arg Trp Glu Asn Phe Ile His Ser
        275                 280                 285             
Glu Asn Arg His Leu Val Ser Pro Glu Ala Leu Asp Leu Leu Asp Lys
    290                 295                 300                 
Leu Leu Arg Tyr Asp His Gln Gln Arg Leu Thr Ala Lys Glu Ala Met
305                 310                 315                 320 
Glu His Pro Tyr Phe Tyr Pro Val Val Lys Glu Gln Ser Gln Pro Cys
                325                 330                 335     
Ala Asp Asn Ala Val Leu Ser Ser Gly Leu Thr Ala Ala Arg
            340                 345                 350 


<210> 7534
<211> 253
<212> PRT
<213> Homo sapiens

<400> 7534
Thr Arg Gly Lys Met Ala Asp Ser Ser Gly Arg Gly Ala Gly Lys Pro
 1               5                  10                  15      
Ala Thr Gly Pro Thr Asn Ser Ser Ser Ala Lys Lys Lys Asp Lys Arg
            20                  25                  30          
Val Gln Gly Gly Arg Val Ile Glu Ser Arg Tyr Leu Gln Tyr Glu Lys
        35                  40                  45              
Lys Thr Thr Gln Lys Ala Pro Ala Gly Asp Gly Ser Gln Thr Arg Gly
    50                  55                  60                  
Lys Met Ser Glu Gly Gly Arg Lys Ser Ser Leu Leu Gln Lys Ser Lys
65                  70                  75                  80  
Ala Asp Ser Ser Gly Val Gly Lys Gly Asp Leu Gln Ser Thr Leu Leu
                85                  90                  95      
Glu Gly His Gly Thr Ala Pro Pro Asp Leu Asp Leu Ser Ala Ile Asn
            100                 105                 110         
Asp Lys Ser Ile Val Lys Lys Thr Pro Gln Leu Ala Lys Thr Ile Ser
        115                 120                 125             
Lys Lys Pro Glu Ser Thr Ser Phe Ser Ala Pro Arg Lys Lys Ser Pro
    130                 135                 140                 
Asp Leu Ser Glu Ala Met Glu Met Met Glu Ser Gln Thr Leu Leu Leu
145                 150                 155                 160 
Thr Leu Leu Ser Val Lys Met Glu Asn Asn Leu Ala Glu Phe Glu Arg
                165                 170                 175     
Arg Ala Glu Lys Asn Leu Leu Ile Met Cys Lys Glu Lys Glu Lys Leu
            180                 185                 190         
Gln Lys Lys Ala His Glu Leu Lys Arg Arg Leu Leu Leu Ser Gln Arg
        195                 200                 205             
Lys Arg Glu Leu Ala Asp Val Leu Asp Ala Gln Ile Glu Met Leu Ser
    210                 215                 220                 
Pro Leu Arg Gly Ser Gly His Thr Leu Gln Gly Ala Ile Gln Asp Ile
225                 230                 235                 240 
Arg His Gly Pro Trp Thr Leu Pro Gly Thr Ser Cys Pro
                245                 250             


<210> 7535
<211> 787
<212> PRT
<213> Homo sapiens

<400> 7535
Met Ser Val Gln Ser Ser Ser Gly Ser Leu Glu Gly Pro Pro Ser Trp
 1               5                  10                  15      
Ser Gln Leu Ser Thr Ser Pro Thr Pro Gly Ser Ala Ala Ala Ala Arg
            20                  25                  30          
Ser Leu Leu Asn His Thr Pro Pro Ser Gly Arg Pro Arg Glu Gly Ala
        35                  40                  45              
Met Asp Glu Leu His Ser Leu Asp Pro Arg Arg Gln Glu Leu Leu Glu
    50                  55                  60                  
Ala Arg Phe Thr Gly Val Ala Ser Gly Ser Thr Gly Ser Thr Gly Ser
65                  70                  75                  80  
Cys Ser Val Gly Ala Lys Ala Ser Thr Asn Asn Glu Ser Ser Asn His
                85                  90                  95      
Ser Phe Gly Ser Leu Gly Ser Leu Ser Asp Lys Glu Ser Glu Thr Pro
            100                 105                 110         
Glu Lys Lys Gln Ser Glu Ser Ser Arg Gly Arg Lys Arg Lys Ala Glu
        115                 120                 125             
Asn Gln Asn Glu Ser Ser Gln Gly Phe Pro Asn Leu Pro Val Phe Gln
    130                 135                 140                 
Ser Leu Ala Tyr Trp Glu Met Gly Arg Thr Ala Gly Gly Lys Ser Ile
145                 150                 155                 160 
Gly Gly Arg Gly His Lys Ile Ser Asp Tyr Phe Glu Tyr Gln Gly Gly
                165                 170                 175     
Asn Gly Ser Ser Pro Val Arg Gly Ile Pro Pro Ala Ile Arg Ser Pro
            180                 185                 190         
Gln Asn Ser His Ser His Ser Thr Pro Ser Ser Ser Val Arg Pro Asn
        195                 200                 205             
Ser Pro Ser Pro Thr Ala Leu Ala Phe Gly Asp His Pro Ile Val Gln
    210                 215                 220                 
Pro Lys Gln Leu Ser Phe Lys Ile Ile Gln Thr Asp Leu Thr Met Leu
225                 230                 235                 240 
Lys Leu Ala Ala Leu Glu Ser Asn Lys Ile Gln Asp Leu Glu Lys Lys
                245                 250                 255     
Glu Gly Arg Ile Asp Asp Leu Leu Arg Ala Asn Cys Asp Leu Arg Arg
            260                 265                 270         
Gln Ile Asp Glu Gln Gln Lys Leu Leu Glu Lys Tyr Lys Glu Arg Leu
        275                 280                 285             
Asn Lys Cys Ile Ser Met Ser Lys Lys Leu Leu Ile Glu Lys Ser Thr
    290                 295                 300                 
Gln Glu Lys Leu Ser Ser Arg Glu Lys Ser Met Gln Asp Arg Leu Arg
305                 310                 315                 320 
Leu Gly His Phe Thr Thr Val Arg His Gly Ala Ser Phe Thr Glu Gln
                325                 330                 335     
Trp Thr Asp Gly Phe Ala Phe Gln Asn Leu Val Lys Gln Gln Glu Trp
            340                 345                 350         
Val Asn Gln Gln Arg Glu Asp Ile Glu Arg Gln Arg Lys Leu Leu Ala
        355                 360                 365             
Lys Arg Lys Pro Pro Thr Ala Asn Asn Ser Gln Ala Pro Ser Thr Asn
    370                 375                 380                 
Ser Glu Pro Lys Gln Arg Lys Asn Lys Ala Val Asn Gly Ala Glu Asn
385                 390                 395                 400 
Asp Pro Phe Val Arg Pro Asn Leu Pro Gln Leu Leu Thr Leu Ala Glu
                405                 410                 415     
Tyr His Glu Gln Glu Glu Ile Phe Lys Leu Arg Leu Gly His Leu Lys
            420                 425                 430         
Lys Glu Glu Ala Glu Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg Val
        435                 440                 445             
Arg Asn Leu His Ile Arg Glu Leu Lys Arg Ile Asn Asn Glu Asp Asn
    450                 455                 460                 
Ser Gln Phe Lys Asp His Pro Thr Leu Asn Glu Arg Tyr Leu Leu Leu
465                 470                 475                 480 
His Leu Leu Gly Arg Gly Gly Phe Ser Glu Val Tyr Lys Ala Phe Asp
                485                 490                 495     
Leu Tyr Glu Gln Arg Tyr Ala Ala Val Lys Ile His Gln Leu Asn Lys
            500                 505                 510         
Ser Trp Arg Asp Glu Lys Lys Glu Asn Tyr His Lys His Ala Cys Arg
        515                 520                 525             
Glu Tyr Arg Ile His Lys Glu Leu Asp His Pro Arg Ile Val Lys Leu
    530                 535                 540                 
Tyr Asp Tyr Phe Ser Leu Asp Thr Asp Thr Phe Cys Thr Val Leu Glu
545                 550                 555                 560 
Tyr Cys Glu Gly Asn Asp Leu Asp Phe Tyr Leu Lys Gln His Lys Leu
                565                 570                 575     
Met Ser Glu Lys Glu Ala Arg Ser Ile Val Met Gln Ile Val Asn Ala
            580                 585                 590         
Leu Arg Tyr Leu Asn Glu Ile Lys Pro Pro Ile Ile His Tyr Asp Leu
        595                 600                 605             
Lys Pro Gly Asn Ile Leu Leu Val Asp Gly Thr Ala Cys Gly Glu Ile
    610                 615                 620                 
Lys Ile Thr Asp Phe Gly Leu Ser Lys Ile Met Asp Asp Asp Ser Tyr
625                 630                 635                 640 
Gly Val Asp Gly Met Asp Leu Thr Ser Gln Gly Ala Gly Thr Tyr Trp
                645                 650                 655     
Tyr Leu Pro Pro Glu Cys Phe Val Val Gly Lys Glu Pro Pro Lys Ile
            660                 665                 670         
Ser Asn Lys Val Asp Val Trp Ser Val Gly Val Ile Phe Phe Gln Cys
        675                 680                 685             
Leu Tyr Gly Arg Lys Pro Phe Gly His Asn Gln Ser Gln Gln Asp Ile
    690                 695                 700                 
Leu Gln Glu Asn Thr Ile Leu Lys Ala Thr Glu Val Gln Phe Pro Val
705                 710                 715                 720 
Lys Pro Val Val Ser Ser Glu Ala Lys Ala Phe Ile Arg Arg Cys Leu
                725                 730                 735     
Ala Tyr Arg Lys Glu Asp Arg Phe Asp Val His Gln Leu Ala Asn Asp
            740                 745                 750         
Pro Tyr Leu Leu Pro His Met Arg Arg Ser Asn Ser Ser Gly Asn Leu
        755                 760                 765             
His Met Ala Gly Leu Thr Ala Ser Pro Thr Pro Pro Ser Ser Ser Ile
    770                 775                 780                 
Ile Thr Tyr
785         


<210> 7536
<211> 766
<212> PRT
<213> Homo sapiens

<400> 7536
Met Ser Val Gln Ser Ser Ser Gly Ser Leu Glu Gly Pro Pro Ser Trp
 1               5                  10                  15      
Ser Gln Leu Ser Thr Ser Pro Thr Pro Gly Ser Ala Ala Ala Ala Arg
            20                  25                  30          
Ser Leu Leu Asn His Thr Pro Pro Ser Gly Arg Pro Arg Glu Gly Ala
        35                  40                  45              
Met Asp Glu Leu His Ser Leu Asp Pro Arg Arg Gln Glu Leu Leu Glu
    50                  55                  60                  
Ala Arg Phe Thr Gly Val Ala Ser Gly Ser Thr Gly Ser Thr Gly Ser
65                  70                  75                  80  
Cys Ser Val Gly Ala Lys Ala Ser Thr Asn Asn Glu Ser Ser Asn His
                85                  90                  95      
Ser Phe Gly Ser Leu Gly Ser Leu Ser Asp Lys Glu Ser Glu Thr Pro
            100                 105                 110         
Glu Lys Lys Gln Ser Glu Ser Ser Arg Gly Arg Lys Arg Lys Ala Glu
        115                 120                 125             
Asn Gln Asn Glu Ser Ser Gln Gly Lys Ser Ile Gly Gly Arg Gly His
    130                 135                 140                 
Lys Ile Ser Asp Tyr Phe Glu Tyr Gln Gly Gly Asn Gly Ser Ser Pro
145                 150                 155                 160 
Val Arg Gly Ile Pro Pro Ala Ile Arg Ser Pro Gln Asn Ser His Ser
                165                 170                 175     
His Ser Thr Pro Ser Ser Ser Val Arg Pro Asn Ser Pro Ser Pro Thr
            180                 185                 190         
Ala Leu Ala Phe Gly Asp His Pro Ile Val Gln Pro Lys Gln Leu Ser
        195                 200                 205             
Phe Lys Ile Ile Gln Thr Asp Leu Thr Met Leu Lys Leu Ala Ala Leu
    210                 215                 220                 
Glu Ser Asn Lys Ile Gln Asp Leu Glu Lys Lys Glu Gly Arg Ile Asp
225                 230                 235                 240 
Asp Leu Leu Arg Ala Asn Cys Asp Leu Arg Arg Gln Ile Asp Glu Gln
                245                 250                 255     
Gln Lys Leu Leu Glu Lys Tyr Lys Glu Arg Leu Asn Lys Cys Ile Ser
            260                 265                 270         
Met Ser Lys Lys Leu Leu Ile Glu Lys Ser Thr Gln Glu Lys Leu Ser
        275                 280                 285             
Ser Arg Glu Lys Ser Met Gln Asp Arg Leu Arg Leu Gly His Phe Thr
    290                 295                 300                 
Thr Val Arg His Gly Ala Ser Phe Thr Glu Gln Trp Thr Asp Gly Phe
305                 310                 315                 320 
Ala Phe Gln Asn Leu Val Lys Gln Gln Glu Trp Val Asn Gln Gln Arg
                325                 330                 335     
Glu Asp Ile Glu Arg Gln Arg Lys Leu Leu Ala Lys Arg Lys Pro Pro
            340                 345                 350         
Thr Ala Asn Asn Ser Gln Ala Pro Ser Thr Asn Ser Glu Pro Lys Gln
        355                 360                 365             
Arg Lys Asn Lys Ala Val Asn Gly Ala Glu Asn Asp Pro Phe Val Arg
    370                 375                 380                 
Pro Asn Leu Pro Gln Leu Leu Thr Leu Ala Glu Tyr His Glu Gln Glu
385                 390                 395                 400 
Glu Ile Phe Lys Leu Arg Leu Gly His Leu Lys Lys Glu Glu Ala Glu
                405                 410                 415     
Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg Val Arg Asn Leu His Ile
            420                 425                 430         
Arg Glu Leu Lys Arg Ile Asn Asn Glu Asp Asn Ser Gln Phe Lys Asp
        435                 440                 445             
His Pro Thr Leu Asn Glu Arg Tyr Leu Leu Leu His Leu Leu Gly Arg
    450                 455                 460                 
Gly Gly Phe Ser Glu Val Tyr Lys Ala Phe Asp Leu Tyr Glu Gln Arg
465                 470                 475                 480 
Tyr Ala Ala Val Lys Ile His Gln Leu Asn Lys Ser Trp Arg Asp Glu
                485                 490                 495     
Lys Lys Glu Asn Tyr His Lys His Ala Cys Arg Glu Tyr Arg Ile His
            500                 505                 510         
Lys Glu Leu Asp His Pro Arg Ile Val Lys Leu Tyr Asp Tyr Phe Ser
        515                 520                 525             
Leu Asp Thr Asp Thr Phe Cys Thr Val Leu Glu Tyr Cys Glu Gly Asn
    530                 535                 540                 
Asp Leu Asp Phe Tyr Leu Lys Gln His Lys Leu Met Ser Glu Lys Glu
545                 550                 555                 560 
Ala Arg Ser Ile Val Met Gln Ile Val Asn Ala Leu Arg Tyr Leu Asn
                565                 570                 575     
Glu Ile Lys Pro Pro Ile Ile His Tyr Asp Leu Lys Pro Gly Asn Ile
            580                 585                 590         
Leu Leu Val Asp Gly Thr Ala Cys Gly Glu Ile Lys Ile Thr Asp Phe
        595                 600                 605             
Gly Leu Ser Lys Ile Met Asp Asp Asp Ser Tyr Gly Val Asp Gly Met
    610                 615                 620                 
Asp Leu Thr Ser Gln Gly Ala Gly Thr Tyr Trp Tyr Leu Pro Pro Glu
625                 630                 635                 640 
Cys Phe Val Val Gly Lys Glu Pro Pro Lys Ile Ser Asn Lys Val Asp
                645                 650                 655     
Val Trp Ser Val Gly Val Ile Phe Phe Gln Cys Leu Tyr Gly Arg Lys
            660                 665                 670         
Pro Phe Gly His Asn Gln Ser Gln Gln Asp Ile Leu Gln Glu Asn Thr
        675                 680                 685             
Ile Leu Lys Ala Thr Glu Val Gln Phe Pro Val Lys Pro Val Val Ser
    690                 695                 700                 
Ser Glu Ala Lys Ala Phe Ile Arg Arg Cys Leu Ala Tyr Arg Lys Glu
705                 710                 715                 720 
Asp Arg Phe Asp Val His Gln Leu Ala Asn Asp Pro Tyr Leu Leu Pro
                725                 730                 735     
His Met Arg Arg Ser Asn Ser Ser Gly Asn Leu His Met Ala Gly Leu
            740                 745                 750         
Thr Ala Ser Pro Thr Pro Pro Ser Ser Ser Ile Ile Thr Tyr
        755                 760                 765     


<210> 7537
<211> 442
<212> PRT
<213> Homo sapiens

<400> 7537
Gly Ser Ser Ser Phe Arg Gly Gly Leu Gly Gly Gly Tyr Ser Gly Ala
 1               5                  10                  15      
Ser Gly Met Gly Gly Ile Thr Ala Val Met Val Asn Gln Ser Leu Leu
            20                  25                  30          
Ser Pro Leu Val Leu Glu Val Asp Pro Asn Ile Gln Ala Val Cys Thr
        35                  40                  45              
Gln Glu Lys Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser Phe
    50                  55                  60                  
Thr Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Met Leu Glu Thr
65                  70                  75                  80  
Lys Trp Ser Leu Leu Gln Gln Gln Lys Met Ala Arg Ser Asn Met Asp
                85                  90                  95      
Asn Met Phe Glu Ser Tyr Ile Asn Asn Leu Arg Arg Gln Leu Glu Thr
            100                 105                 110         
Leu Gly Gln Glu Lys Leu Lys Leu Glu Ala Glu Leu Gly Asn Met Gln
        115                 120                 125             
Arg Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu Ile Asn Lys
    130                 135                 140                 
His Thr Glu Met Glu Asn Glu Phe Val Leu Ile Lys Lys Asp Val Asp
145                 150                 155                 160 
Glu Ala Tyr Met Asn Lys Val Glu Leu Glu Ser Arg Leu Glu Gly Leu
                165                 170                 175     
Thr Asp Glu Ile Asn Phe Leu Arg Gln Leu Tyr Glu Lys Glu Ile Arg
            180                 185                 190         
Glu Leu Gln Ser Gln Ile Ser Asp Thr Ser Val Val Leu Ser Met Asp
        195                 200                 205             
Asn Ser Arg Ser Leu Asp Met Asp Ser Ile Ile Ala Glu Val Lys Ala
    210                 215                 220                 
Gln Tyr Glu Asp Ile Ala Asn Gln Arg Arg Ala Glu Ala Glu Ser Met
225                 230                 235                 240 
Tyr Gln Ile Lys Tyr Glu Glu Leu Gln Ser Leu Ala Gly Lys His Gly
                245                 250                 255     
Asp Asp Leu Trp Arg Thr Lys Thr Glu Ile Ser Glu Met Asn Trp Asn
            260                 265                 270         
Ile Ser Gln Leu Gln Ala Glu Ile Glu Gly Leu Lys Gly Gln Arg Ala
        275                 280                 285             
Ser Leu Glu Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly Glu Leu Ala
    290                 295                 300                 
Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu Gln
305                 310                 315                 320 
Arg Ala Lys Gln Asp Met Ala Arg Gln Leu Arg Glu Tyr Gln Glu Leu
                325                 330                 335     
Met Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys
            340                 345                 350         
Leu Leu Glu Gly Lys Glu Ser Arg Leu Lys Ser Gly Met Gln Asn Met
        355                 360                 365             
Ser Ile His Thr Lys Thr Thr Ser Gly Tyr Ala Gly Gly Leu Ser Ser
    370                 375                 380                 
Ala Tyr Gly Gly Leu Thr Ser Pro Gly Leu Ser Tyr Gly Leu Gly Ser
385                 390                 395                 400 
Ser Phe Gly Ser Gly Ala Gly Ser Ser Ser Leu Ser Arg Thr Ser Ser
                405                 410                 415     
Ser Arg Ala Val Val Val Lys Lys Ile Glu Thr Cys Asp Gly Lys Leu
            420                 425                 430         
Val Ser Glu Ser Ser Asp Ile Leu Pro Lys
        435                 440         


<210> 7538
<211> 482
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 287, 372
<223> Xaa = Any Amino Acid

<400> 7538
Met Ser Ile Arg Thr Thr Gln Lys Ser Tyr Arg Val Ser Thr Ser Gly
 1               5                  10                  15      
Pro Arg Ala Phe Ser Ser His Phe Tyr Thr Ser Gly Pro Gly Ala Ser
            20                  25                  30          
Ile Ser Ser Ser Ser Phe Ser Gln Val Gly Ser Ser Ser Phe Arg Gly
        35                  40                  45              
Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr
    50                  55                  60                  
Thr Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Asn Leu Glu Val
65                  70                  75                  80  
Asp Pro His Ile Gln Ala Val His Thr Gln Lys Lys Glu Gln Ile Lys
                85                  90                  95      
Thr Leu Asn Thr Lys Phe Ala Thr Phe Ile Tyr Lys Val Gln Phe Leu
            100                 105                 110         
Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln
        115                 120                 125             
Gln Lys Thr Ala Arg Ser Asn Met Asp Thr Ile Phe Gln Ser Tyr Ile
    130                 135                 140                 
Asn Asn Leu Arg Gln Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys
145                 150                 155                 160 
Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys
                165                 170                 175     
Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu
            180                 185                 190         
Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Leu Asn Lys Val
        195                 200                 205             
Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu
    210                 215                 220                 
Arg Gln Leu Tyr Glu Glu Asp Ile Pro Glu Leu Gln Ser Gln Ile Ser
225                 230                 235                 240 
Asp Thr Ser Val Val Leu Pro Met Asp Asn Ser His Ser Leu Asp Met
                245                 250                 255     
Asp Ser Ile Ile Asn Glu Val Lys Arg Ser Tyr Glu Ile Thr Asn Arg
            260                 265                 270         
Ser Gln Val Glu Ala Gln Ser Met Tyr Gln Ile Lys Tyr Glu Xaa Leu
        275                 280                 285             
Gln Thr Leu Ala Gly Lys His Gly Asp Asp Leu Gln His Thr Lys Thr
    290                 295                 300                 
Glu Ile Ser Ala Met Asn Arg Asn Ile Ser Trp Leu Gln Ala Glu Ile
305                 310                 315                 320 
Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala Asp
                325                 330                 335     
Ala Glu Gln Arg Gly Glu Leu Ala Val Lys Asp Ala Ser Ala Lys Leu
            340                 345                 350         
Ser Glu Leu Glu Ala Ala Leu Gln Gln Thr Lys Gln Asp Val Val Leu
        355                 360                 365             
Gln Leu His Xaa Tyr Gln Glu Leu Met Asn Asp Lys Leu Ala Leu Asp
    370                 375                 380                 
Ile Glu Ile Ala Thr Tyr Arg Gln Leu Leu Glu Gly Glu Glu Ser Trp
385                 390                 395                 400 
Leu Glu Ser Gly Met Gln Ser Met Ser Ile His Thr Lys Thr Ile Ser
                405                 410                 415     
Ser Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser Pro
            420                 425                 430         
Gly Leu Ser Cys Gly Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly Ser
        435                 440                 445             
Ser Ser Phe Ser Cys Ile Ser Tyr Thr Arg Ala Val Val Val Lys Lys
    450                 455                 460                 
Ile Glu Thr Arg Asp Gly Thr Leu Val Ser Glu Phe Ser Asp Val Leu
465                 470                 475                 480 
Pro Lys
        


<210> 7539
<211> 448
<212> PRT
<213> Homo sapiens

<400> 7539
Met Ala Glu Ala Ser Ala Thr Gly Ala Cys Gly Glu Ala Met Ala Ala
 1               5                  10                  15      
Ala Glu Gly Ser Ser Gly Pro Ala Gly Leu Thr Leu Gly Arg Ser Phe
            20                  25                  30          
Ser Asn Tyr Arg Pro Phe Glu Pro Gln Ala Leu Gly Leu Ser Pro Ser
        35                  40                  45              
Trp Arg Leu Thr Gly Phe Ser Gly Met Lys Gly Cys Gly Cys Lys Val
    50                  55                  60                  
Pro Gln Glu Ala Leu Leu Lys Leu Leu Ala Gly Leu Thr Arg Pro Asp
65                  70                  75                  80  
Val Arg Pro Pro Leu Gly Arg Gly Leu Val Gly Gly Gln Glu Glu Ala
                85                  90                  95      
Ser Gln Glu Ala Gly Leu Pro Ala Gly Ala Gly Pro Ser Pro Thr Phe
            100                 105                 110         
Pro Ala Leu Gly Ile Gly Met Asp Ser Cys Val Ile Pro Leu Arg His
        115                 120                 125             
Gly Gly Leu Ser Leu Val Gln Thr Thr Asp Phe Phe Tyr Pro Leu Val
    130                 135                 140                 
Glu Asp Pro Tyr Met Met Gly Arg Ile Ala Cys Ala Asn Val Leu Ser
145                 150                 155                 160 
Asp Leu Tyr Ala Met Gly Ile Thr Glu Cys Asp Asn Met Leu Met Leu
                165                 170                 175     
Leu Ser Val Ser Gln Ser Met Ser Glu Glu Glu Arg Glu Lys Val Thr
            180                 185                 190         
Pro Leu Met Val Lys Gly Phe Arg Asp Ala Ala Glu Glu Gly Gly Thr
        195                 200                 205             
Ala Val Thr Gly Gly Gln Thr Val Val Asn Pro Trp Ile Ile Ile Gly
    210                 215                 220                 
Gly Val Ala Thr Val Val Cys Gln Pro Asn Glu Phe Ile Met Pro Asp
225                 230                 235                 240 
Ser Ala Val Val Gly Asp Val Leu Val Leu Thr Lys Pro Leu Gly Thr
                245                 250                 255     
Gln Val Ala Val Asn Ala His Gln Trp Leu Asp Asn Pro Glu Arg Trp
            260                 265                 270         
Asn Lys Val Lys Met Val Val Ser Arg Glu Glu Val Glu Leu Ala Tyr
        275                 280                 285             
Gln Glu Ala Met Phe Asn Met Ala Thr Leu Asn Arg Thr Ala Ala Gly
    290                 295                 300                 
Leu Met His Thr Phe Asn Ala His Ala Ala Thr Asp Ile Thr Gly Phe
305                 310                 315                 320 
Gly Ile Leu Gly His Ser Gln Asn Leu Ala Lys Gln Gln Arg Asn Glu
                325                 330                 335     
Val Ser Phe Val Ile His Asn Leu Pro Ile Ile Ala Lys Met Ala Ala
            340                 345                 350         
Val Ser Lys Ala Ser Gly Arg Phe Gly Leu Leu Gln Gly Thr Ser Ala
        355                 360                 365             
Glu Thr Ser Gly Gly Leu Leu Ile Cys Leu Pro Arg Glu Gln Ala Ala
    370                 375                 380                 
Arg Phe Cys Ser Glu Ile Lys Ser Ser Lys Tyr Gly Glu Gly His Gln
385                 390                 395                 400 
Ala Trp Ile Val Gly Ile Val Glu Lys Gly Asn Arg Thr Ala Arg Ile
                405                 410                 415     
Ile Asp Lys Pro Arg Val Ile Glu Val Leu Pro Arg Gly Ala Thr Ala
            420                 425                 430         
Ala Val Leu Ala Pro Asp Ser Ser Asn Ala Ser Ser Glu Pro Ser Ser
        435                 440                 445             


<210> 7540
<211> 399
<212> PRT
<213> Homo sapiens

<400> 7540
Met Ala Glu Ala Ser Ala Thr Gly Ala Cys Gly Glu Ala Met Ala Ala
 1               5                  10                  15      
Ala Glu Gly Ser Ser Gly Pro Ala Gly Leu Thr Leu Gly Arg Leu Thr
            20                  25                  30          
Gly Phe Ser Gly Met Lys Gly Leu Val Gly Gly Gln Glu Glu Ala Ser
        35                  40                  45              
Gln Glu Ala Gly Leu Pro Ala Gly Ala Gly Pro Ser Pro Thr Phe Pro
    50                  55                  60                  
Ala Leu Gly Ile Gly Met Asp Ser Cys Val Ile Pro Leu Arg His Gly
65                  70                  75                  80  
Gly Leu Ser Leu Val Gln Thr Thr Asp Phe Phe Tyr Pro Leu Val Glu
                85                  90                  95      
Asp Pro Tyr Met Met Gly Arg Ile Ala Cys Ala Asn Val Leu Ser Asp
            100                 105                 110         
Leu Tyr Ala Met Gly Ile Thr Glu Cys Asp Asn Met Leu Met Leu Leu
        115                 120                 125             
Ser Val Ser Gln Ser Met Ser Glu Glu Glu Arg Glu Lys Val Thr Pro
    130                 135                 140                 
Leu Met Val Lys Gly Phe Arg Asp Ala Ala Glu Glu Gly Gly Thr Ala
145                 150                 155                 160 
Val Thr Gly Gly Gln Thr Val Val Asn Pro Trp Ile Ile Ile Gly Glu
                165                 170                 175     
Val Ala Thr Val Val Cys Gln Pro Asn Glu Phe Ile Met Pro Asp Ser
            180                 185                 190         
Ala Val Val Gly Asp Val Leu Val Leu Thr Lys Pro Leu Gly Thr Gln
        195                 200                 205             
Val Ala Val Asn Ala His Gln Trp Leu Asp Asn Pro Glu Arg Trp Asn
    210                 215                 220                 
Lys Val Lys Met Val Val Ser Arg Glu Glu Val Glu Leu Ala Tyr Gln
225                 230                 235                 240 
Glu Ala Met Phe Asn Met Ala Thr Leu Asn Arg Thr Ala Ala Gly Leu
                245                 250                 255     
Met His Thr Phe Asn Ala His Ala Ala Thr Asp Ile Thr Gly Phe Gly
            260                 265                 270         
Ile Leu Gly His Ser Gln Asn Leu Ala Lys Gln Gln Arg Asn Glu Val
        275                 280                 285             
Ser Phe Val Ile His Asn Leu Pro Ile Ile Ala Lys Met Ala Ala Val
    290                 295                 300                 
Ser Lys Ala Ser Gly Arg Phe Gly Leu Leu Gln Gly Thr Ser Ala Glu
305                 310                 315                 320 
Thr Ser Gly Gly Leu Leu Ile Cys Leu Pro Arg Glu Gln Ala Ala Arg
                325                 330                 335     
Phe Cys Ser Glu Ile Lys Ser Ser Lys Tyr Gly Glu Gly His Gln Ala
            340                 345                 350         
Trp Ile Val Gly Ile Val Glu Lys Gly Asn Arg Thr Ala Arg Ile Ile
        355                 360                 365             
Asp Lys Pro Arg Val Ile Glu Val Leu Pro Arg Gly Ala Thr Ala Ala
    370                 375                 380                 
Val Leu Ala Pro Asp Ser Ser Asn Ala Ser Ser Glu Pro Ser Ser
385                 390                 395                 


<210> 7541
<211> 898
<212> PRT
<213> Homo sapiens

<400> 7541
Met Ser Val Thr Glu Glu Asp Leu Cys His His Met Lys Val Val Val
 1               5                  10                  15      
Arg Val Arg Pro Glu Asn Thr Lys Glu Lys Ala Ala Gly Phe His Lys
            20                  25                  30          
Val Val His Val Val Asp Lys His Ile Leu Val Phe Asp Pro Lys Gln
        35                  40                  45              
Glu Glu Val Ser Phe Phe His Gly Lys Lys Thr Thr Asn Gln Asn Val
    50                  55                  60                  
Ile Lys Lys Gln Asn Lys Asp Leu Lys Phe Val Phe Asp Ala Val Phe
65                  70                  75                  80  
Asp Glu Thr Ser Thr Gln Ser Glu Val Phe Glu His Thr Thr Lys Pro
                85                  90                  95      
Ile Leu Arg Ser Phe Leu Asn Gly Tyr Asn Cys Thr Val Leu Ala Tyr
            100                 105                 110         
Gly Ala Thr Gly Ala Gly Lys Thr His Thr Met Leu Gly Ser Ala Asp
        115                 120                 125             
Glu Pro Gly Val Met Tyr Leu Thr Met Leu His Leu Tyr Lys Cys Met
    130                 135                 140                 
Asp Glu Ile Lys Glu Glu Lys Ile Cys Ser Thr Ala Val Ser Tyr Leu
145                 150                 155                 160 
Glu Val Tyr Asn Glu Gln Ile Arg Asp Leu Leu Val Asn Ser Gly Pro
                165                 170                 175     
Leu Ala Val Arg Glu Asp Thr Gln Lys Gly Val Val Val His Gly Leu
            180                 185                 190         
Thr Leu His Gln Pro Lys Ser Ser Glu Glu Ile Leu His Leu Leu Asp
        195                 200                 205             
Asn Gly Asn Lys Asn Arg Thr Gln His Pro Thr Asp Met Asn Ala Thr
    210                 215                 220                 
Ser Ser Arg Ser His Ala Val Phe Gln Ile Tyr Leu Arg Gln Gln Asp
225                 230                 235                 240 
Lys Thr Ala Ser Ile Asn Gln Asn Val Arg Ile Ala Lys Met Ser Leu
                245                 250                 255     
Ile Asp Leu Ala Gly Ser Glu Arg Ala Ser Thr Ser Gly Ala Lys Gly
            260                 265                 270         
Thr Arg Phe Val Glu Gly Thr Asn Ile Asn Arg Ser Leu Leu Ala Leu
        275                 280                 285             
Gly Asn Val Ile Asn Ala Leu Ala Asp Ser Lys Arg Lys Asn Gln His
    290                 295                 300                 
Ile Pro Tyr Arg Asn Ser Lys Leu Thr Arg Leu Leu Lys Asp Ser Leu
305                 310                 315                 320 
Gly Gly Asn Cys Gln Thr Ile Met Ile Ala Ala Val Ser Pro Ser Ser
                325                 330                 335     
Val Phe Tyr Asp Asp Thr Tyr Asn Thr Leu Lys Tyr Ala Asn Arg Ala
            340                 345                 350         
Lys Asp Ile Lys Ser Ser Leu Lys Ser Asn Val Leu Asn Val Asn Asn
        355                 360                 365             
His Ile Thr Gln Tyr Val Lys Ile Cys Asn Glu Gln Lys Ala Glu Ile
    370                 375                 380                 
Leu Leu Leu Lys Glu Lys Leu Lys Ala Tyr Glu Glu Gln Lys Ala Phe
385                 390                 395                 400 
Thr Asn Glu Asn Asp Gln Ala Lys Leu Met Ile Ser Asn Pro Gln Glu
                405                 410                 415     
Lys Glu Ile Glu Arg Phe Gln Glu Ile Leu Asn Cys Leu Phe Gln Asn
            420                 425                 430         
Arg Glu Glu Ile Arg Gln Glu Tyr Leu Lys Leu Glu Met Leu Leu Lys
        435                 440                 445             
Glu Asn Glu Leu Lys Ser Phe Tyr Gln Gln Gln Cys His Lys Gln Ile
    450                 455                 460                 
Glu Met Met Cys Ser Glu Asp Lys Val Glu Lys Ala Thr Gly Lys Arg
465                 470                 475                 480 
Asp His Arg Leu Ala Met Leu Lys Thr Arg Arg Ser Tyr Leu Glu Lys
                485                 490                 495     
Arg Arg Glu Glu Glu Leu Lys Gln Phe Asp Glu Asn Thr Asn Trp Leu
            500                 505                 510         
His Arg Val Glu Lys Glu Met Gly Leu Leu Ser Gln Asn Gly His Ile
        515                 520                 525             
Pro Lys Glu Leu Lys Lys Asp Leu His Cys His His Leu His Leu Gln
    530                 535                 540                 
Asn Lys Asp Leu Lys Ala Gln Ile Arg His Met Met Asp Leu Ala Cys
545                 550                 555                 560 
Leu Gln Glu Gln Gln His Arg Gln Thr Glu Ala Val Leu Asn Ala Leu
                565                 570                 575     
Leu Pro Thr Leu Arg Lys Gln Tyr Cys Thr Leu Lys Glu Ala Gly Leu
            580                 585                 590         
Ser Asn Ala Ala Phe Glu Ser Asp Phe Lys Glu Ile Glu His Leu Val
        595                 600                 605             
Glu Arg Lys Lys Val Val Val Trp Ala Asp Gln Thr Gly Glu Gln Pro
    610                 615                 620                 
Lys Gln Asn Asp Leu Pro Gly Ile Ser Val Leu Met Thr Phe Ser Gln
625                 630                 635                 640 
Leu Gly Pro Val Gln Pro Ile Pro Cys Cys Ser Ser Ser Gly Gly Thr
                645                 650                 655     
Asn Leu Val Lys Ile Pro Thr Glu Lys Arg Thr Arg Arg Lys Leu Met
            660                 665                 670         
Pro Ser Pro Leu Lys Gly Gln His Thr Leu Lys Ser Pro Pro Ser Gln
        675                 680                 685             
Ser Val Gln Leu Asn Asp Ser Leu Ser Lys Glu Leu Gln Pro Ile Val
    690                 695                 700                 
Tyr Thr Pro Glu Asp Cys Arg Lys Ala Phe Gln Asn Pro Ser Thr Val
705                 710                 715                 720 
Thr Leu Met Lys Pro Ser Ser Phe Thr Thr Ser Phe Gln Ala Ile Ser
                725                 730                 735     
Ser Asn Ile Asn Ser Asp Asn Cys Leu Lys Met Leu Cys Glu Val Ala
            740                 745                 750         
Ile Pro His Asn Arg Arg Lys Glu Cys Gly Gln Glu Asp Leu Asp Ser
        755                 760                 765             
Thr Phe Thr Ile Cys Glu Asp Ile Lys Ser Ser Lys Cys Lys Leu Pro
    770                 775                 780                 
Glu Gln Glu Ser Leu Pro Asn Asp Asn Lys Asp Ile Leu Gln Arg Leu
785                 790                 795                 800 
Asp Pro Ser Ser Phe Ser Thr Lys His Ser Met Pro Val Pro Ser Met
                805                 810                 815     
Val Pro Ser Tyr Met Ala Met Thr Thr Ala Ala Lys Arg Lys Arg Lys
            820                 825                 830         
Leu Thr Ser Ser Thr Ser Asn Ser Ser Leu Thr Ala Asp Val Asn Ser
        835                 840                 845             
Gly Phe Ala Lys Arg Val Arg Gln Asp Asn Ser Ser Glu Lys His Leu
    850                 855                 860                 
Gln Glu Asn Lys Pro Thr Met Glu His Lys Arg Asn Ile Cys Lys Ile
865                 870                 875                 880 
Asn Pro Ser Met Val Arg Lys Phe Gly Arg Asn Ile Ser Lys Gly Asn
                885                 890                 895     
Leu Arg
        


<210> 7542
<211> 223
<212> PRT
<213> Homo sapiens

<400> 7542
Met Glu Val Gln Lys Glu Ala Gln Arg Ile Met Thr Leu Ser Val Trp
 1               5                  10                  15      
Lys Met Tyr His Ser Arg Met Gln Arg Gly Gly Leu Arg Leu His Arg
            20                  25                  30          
Ser Leu Gln Leu Ser Leu Val Met Arg Ser Ala Arg Glu Leu Tyr Leu
        35                  40                  45              
Ser Ala Lys Val Glu Ala Leu Glu Pro Glu Val Ser Leu Pro Ala Ala
    50                  55                  60                  
Leu Pro Ser Asp Pro Arg Leu His Pro Pro Arg Glu Ala Glu Ser Thr
65                  70                  75                  80  
Ala Glu Thr Ala Thr Pro Asp Gly Glu His Pro Phe Pro Glu Pro Met
                85                  90                  95      
Asp Thr Gln Glu Ala Pro Thr Ala Glu Glu Thr Ser Ala Cys Cys Ala
            100                 105                 110         
Pro Arg Pro Ala Lys Val Ser Arg Lys Arg Arg Ser Ser Ser Leu Ser
        115                 120                 125             
Asp Gly Gly Asp Val Gly Leu Val Pro Ser Lys Lys Ala Arg Leu Glu
    130                 135                 140                 
Glu Lys Glu Glu Glu Glu Gly Ala Ser Ser Glu Val Ala Asp Arg Leu
145                 150                 155                 160 
Gln Pro Pro Pro Gly Gln Ala Glu Gly Ala Phe Pro Asn Leu Ala Arg
                165                 170                 175     
Val Leu Gln Arg Arg Phe Ser Gly Leu Leu Asn Cys Ser Pro Ala Ala
            180                 185                 190         
Pro Pro Thr Ala Pro Pro Ala Cys Glu Ala Lys Pro Ala Cys Arg Pro
        195                 200                 205             
Ala Asp Ser Met Leu Asn Val Leu Val Arg Ala Val Val Ala Phe
    210                 215                 220             


<210> 7543
<211> 217
<212> PRT
<213> Homo sapiens

<400> 7543
Met Ser Cys Ala Gly Ala Ala Ala Ala Pro Arg Leu Trp Arg Leu Arg
 1               5                  10                  15      
Pro Gly Ala Arg Arg Ser Leu Ser Ala Tyr Gly Arg Arg Thr Ser Val
            20                  25                  30          
Arg Phe Arg Ser Ser Gly Met Thr Leu Asp Asn Ile Ser Arg Ala Ala
        35                  40                  45              
Val Asp Arg Ile Ile Arg Val Asp His Ala Gly Glu Tyr Gly Ala Asn
    50                  55                  60                  
Arg Ile Tyr Ala Gly Gln Met Ala Val Leu Gly Arg Thr Ser Val Gly
65                  70                  75                  80  
Pro Val Ile Gln Lys Met Trp Asp Gln Glu Lys Asp His Leu Lys Lys
                85                  90                  95      
Phe Asn Glu Leu Met Val Thr Phe Arg Val Arg Pro Thr Val Leu Met
            100                 105                 110         
Pro Leu Trp Asn Val Leu Gly Phe Ala Leu Gly Ala Gly Thr Ala Leu
        115                 120                 125             
Leu Gly Lys Glu Gly Ala Met Ala Cys Thr Val Ala Val Glu Glu Ser
    130                 135                 140                 
Ile Ala His His Tyr Asn Asn Gln Ile Arg Thr Leu Met Glu Glu Asp
145                 150                 155                 160 
Pro Glu Lys Tyr Glu Glu Leu Leu Gln Leu Ile Lys Lys Phe Arg Asp
                165                 170                 175     
Glu Glu Leu Glu His His Asp Ile Gly Leu Asp His Asp Ala Glu Leu
            180                 185                 190         
Ala Pro Ala Tyr Ala Val Leu Lys Ser Ile Ile Gln Ala Gly Cys Arg
        195                 200                 205             
Val Ala Ile Tyr Leu Ser Glu Arg Leu
    210                 215         


<210> 7544
<211> 217
<212> PRT
<213> Homo sapiens

<400> 7544
Met Ser Cys Ala Gly Ala Ala Ala Ala Pro Arg Leu Trp Arg Leu Arg
 1               5                  10                  15      
Pro Gly Ala Arg Arg Ser Leu Ser Ala Tyr Gly Arg Arg Thr Ser Val
            20                  25                  30          
Arg Phe Arg Ser Ser Gly Met Thr Leu Asp Asn Ile Ser Arg Ala Ala
        35                  40                  45              
Val Asp Arg Ile Ile Arg Val Asp His Ala Gly Glu Tyr Gly Ala Asn
    50                  55                  60                  
Arg Ile Tyr Ala Gly Gln Met Ala Val Leu Gly Arg Thr Ser Val Gly
65                  70                  75                  80  
Pro Val Ile Gln Lys Met Trp Asp Gln Glu Lys Asp His Leu Lys Lys
                85                  90                  95      
Phe Asn Glu Leu Met Val Met Phe Arg Val Arg Pro Thr Val Leu Met
            100                 105                 110         
Pro Leu Trp Asn Val Leu Gly Phe Ala Leu Gly Ala Gly Thr Ala Leu
        115                 120                 125             
Leu Gly Lys Glu Gly Ala Met Ala Cys Thr Val Ala Val Glu Glu Ser
    130                 135                 140                 
Ile Ala His His Tyr Asn Asn Gln Ile Arg Thr Leu Met Glu Glu Asp
145                 150                 155                 160 
Pro Glu Lys Tyr Glu Glu Leu Leu Gln Leu Ile Lys Lys Phe Arg Asp
                165                 170                 175     
Glu Glu Leu Glu His His Asp Ile Gly Leu Asp His Asp Ala Glu Leu
            180                 185                 190         
Ala Pro Ala Tyr Ala Val Leu Lys Ser Ile Ile Gln Ala Gly Cys Arg
        195                 200                 205             
Val Ala Ile Tyr Leu Ser Glu Arg Leu
    210                 215         


<210> 7545
<211> 1391
<212> PRT
<213> Homo sapiens

<400> 7545
Met Val Lys Glu Gln Phe Arg Glu Thr Asp Val Ala Lys Lys Thr Ser
 1               5                  10                  15      
His Ile Cys Phe Gly Met Lys Ser Pro Glu Glu Met Arg Gln Gln Ala
            20                  25                  30          
His Ile Gln Val Val Ser Lys Asn Leu Tyr Ser Gln Asp Asn Gln His
        35                  40                  45              
Ala Pro Leu Leu Tyr Gly Val Leu Asp His Arg Met Gly Thr Ser Glu
    50                  55                  60                  
Lys Asp Arg Pro Cys Glu Thr Cys Gly Lys Asn Leu Ala Asp Cys Leu
65                  70                  75                  80  
Gly His Tyr Gly Tyr Ile Asp Leu Glu Leu Pro Cys Phe His Val Gly
                85                  90                  95      
Tyr Phe Arg Ala Val Ile Gly Ile Leu Gln Met Ile Cys Lys Thr Cys
            100                 105                 110         
Cys His Ile Met Leu Ser Gln Glu Glu Lys Lys Gln Phe Leu Asp Tyr
        115                 120                 125             
Leu Lys Arg Pro Gly Leu Thr Tyr Leu Gln Lys Arg Gly Leu Lys Lys
    130                 135                 140                 
Lys Ile Ser Asp Lys Cys Arg Lys Lys Asn Ile Cys His His Cys Gly
145                 150                 155                 160 
Ala Phe Asn Gly Thr Val Lys Lys Cys Gly Leu Leu Lys Ile Ile His
                165                 170                 175     
Glu Lys Tyr Lys Thr Asn Lys Lys Val Val Asp Pro Ile Val Ser Asn
            180                 185                 190         
Phe Leu Gln Ser Phe Glu Thr Ala Ile Glu His Asn Lys Glu Val Glu
        195                 200                 205             
Pro Leu Leu Gly Arg Ala Gln Glu Asn Leu Asn Pro Leu Val Val Leu
    210                 215                 220                 
Asn Leu Phe Lys Arg Ile Pro Ala Glu Asp Val Pro Leu Leu Leu Met
225                 230                 235                 240 
Asn Pro Glu Ala Gly Lys Pro Ser Asp Leu Ile Leu Thr Arg Leu Leu
                245                 250                 255     
Val Pro Pro Leu Cys Phe Arg Pro Ser Val Val Ser Asp Leu Lys Ser
            260                 265                 270         
Gly Thr Asn Glu Asp Asp Leu Thr Met Lys Leu Thr Glu Ile Ile Phe
        275                 280                 285             
Leu Asn Asp Val Ile Lys Lys His Arg Ile Ser Gly Ala Lys Thr Gln
    290                 295                 300                 
Met Ile Met Glu Asp Trp Asp Phe Leu Gln Leu Gln Cys Ala Leu Tyr
305                 310                 315                 320 
Ile Asn Ser Glu Leu Ser Gly Ile Pro Leu Asn Met Ala Pro Lys Lys
                325                 330                 335     
Trp Thr Arg Gly Phe Val Gln Arg Leu Lys Gly Lys Gln Gly Arg Phe
            340                 345                 350         
Arg Gly Asn Leu Ser Gly Lys Arg Val Asp Phe Ser Gly Arg Thr Val
        355                 360                 365             
Ile Ser Pro Asp Pro Asn Leu Arg Ile Asp Glu Val Ala Val Pro Val
    370                 375                 380                 
His Val Ala Lys Ile Leu Thr Phe Pro Glu Lys Val Asn Lys Ala Asn
385                 390                 395                 400 
Ile Asn Phe Leu Arg Lys Leu Val Gln Asn Gly Pro Glu Val His Pro
                405                 410                 415     
Gly Ala Asn Phe Ile Gln Gln Arg His Thr Gln Met Lys Arg Phe Leu
            420                 425                 430         
Lys Tyr Gly Asn Arg Glu Lys Met Ala Gln Glu Leu Lys Tyr Gly Asp
        435                 440                 445             
Ile Val Glu Arg His Leu Ile Asp Gly Asp Val Val Leu Phe Asn Arg
    450                 455                 460                 
Gln Pro Ser Leu His Lys Leu Ser Ile Met Ala His Leu Ala Arg Val
465                 470                 475                 480 
Lys Pro His Arg Thr Phe Arg Phe Asn Glu Cys Val Cys Thr Pro Tyr
                485                 490                 495     
Asn Ala Asp Phe Asp Gly Asp Glu Met Asn Leu His Leu Pro Gln Thr
            500                 505                 510         
Glu Glu Ala Lys Ala Glu Ala Leu Val Leu Met Gly Thr Lys Ala Asn
        515                 520                 525             
Leu Val Thr Pro Arg Asn Gly Glu Pro Leu Ile Ala Ala Ile Gln Asp
    530                 535                 540                 
Phe Leu Thr Gly Ala Tyr Leu Leu Thr Leu Lys Asp Thr Phe Phe Asp
545                 550                 555                 560 
Arg Ala Lys Ala Cys Gln Ile Ile Ala Ser Ile Leu Val Gly Lys Asp
                565                 570                 575     
Glu Lys Ile Lys Val Arg Leu Pro Pro Pro Thr Ile Leu Lys Pro Val
            580                 585                 590         
Thr Leu Trp Thr Gly Lys Gln Ile Phe Ser Val Ile Leu Arg Pro Ser
        595                 600                 605             
Asp Asp Asn Pro Val Arg Ala Asn Leu Arg Thr Lys Gly Lys Gln Tyr
    610                 615                 620                 
Cys Gly Lys Gly Glu Asp Leu Cys Ala Asn Asp Ser Tyr Val Thr Ile
625                 630                 635                 640 
Gln Asn Ser Glu Leu Met Ser Gly Ser Met Asp Lys Gly Thr Leu Gly
                645                 650                 655     
Ser Gly Ser Lys Asn Asn Ile Phe Tyr Ile Leu Leu Arg Asp Trp Gly
            660                 665                 670         
Gln Asn Glu Ala Ala Asp Ala Met Ser Arg Leu Ala Arg Leu Ala Pro
        675                 680                 685             
Val Tyr Leu Ser Asn Arg Gly Phe Ser Ile Gly Ile Gly Asp Val Thr
    690                 695                 700                 
Pro Gly Gln Gly Leu Leu Lys Ala Lys Tyr Glu Leu Leu Asn Ala Gly
705                 710                 715                 720 
Tyr Lys Lys Cys Asp Glu Tyr Ile Glu Ala Leu Asn Thr Gly Lys Leu
                725                 730                 735     
Gln Gln Gln Pro Gly Cys Thr Ala Glu Glu Thr Leu Glu Ala Leu Ile
            740                 745                 750         
Leu Lys Glu Leu Ser Val Ile Arg Asp His Ala Gly Ser Ala Cys Leu
        755                 760                 765             
Arg Glu Leu Asp Lys Ser Asn Ser Pro Leu Thr Met Ala Leu Cys Gly
    770                 775                 780                 
Ser Lys Gly Ser Phe Ile Asn Ile Ser Gln Met Ile Ala Cys Val Gly
785                 790                 795                 800 
Gln Gln Ala Ile Ser Gly Ser Arg Val Pro Asp Gly Phe Glu Asn Arg
                805                 810                 815     
Ser Leu Pro His Phe Glu Lys His Ser Lys Leu Pro Ala Ala Lys Gly
            820                 825                 830         
Phe Val Ala Asn Ser Phe Tyr Ser Gly Leu Thr Pro Thr Glu Phe Phe
        835                 840                 845             
Phe His Thr Met Ala Gly Arg Glu Gly Leu Val Asp Thr Ala Val Lys
    850                 855                 860                 
Thr Ala Glu Thr Gly Tyr Met Gln Arg Arg Leu Val Lys Ser Leu Glu
865                 870                 875                 880 
Asp Leu Cys Ser Gln Tyr Asp Leu Thr Val Arg Ser Ser Thr Gly Asp
                885                 890                 895     
Ile Ile Gln Phe Ile Tyr Gly Gly Asp Gly Leu Asp Pro Ala Ala Met
            900                 905                 910         
Glu Gly Lys Asp Glu Pro Leu Glu Phe Lys Arg Val Leu Asp Asn Ile
        915                 920                 925             
Lys Ala Val Phe Pro Cys Pro Ser Glu Pro Ala Leu Ser Lys Asn Glu
    930                 935                 940                 
Leu Ile Leu Thr Thr Glu Ser Ile Met Lys Lys Ser Glu Phe Leu Cys
945                 950                 955                 960 
Cys Gln Asp Ser Phe Leu Gln Glu Ile Lys Lys Phe Ile Lys Gly Val
                965                 970                 975     
Ser Glu Lys Ile Lys Lys Thr Arg Asp Lys Tyr Gly Ile Asn Asp Asn
            980                 985                 990         
Gly Thr Thr Glu Pro Arg Val Leu Tyr Gln Leu Asp Arg Ile Thr Pro
        995                 1000                1005            
Thr Gln Val Glu Lys Phe Leu Glu Thr Cys Arg Asp Lys Tyr Met Arg
    1010                1015                1020                
Ala Gln Met Glu Pro Gly Ser Ala Val Gly Ala Leu Cys Ala Gln Ser
1025                1030                1035                1040
Ile Gly Glu Pro Gly Thr Gln Met Thr Leu Lys Thr Phe His Phe Gly
                1045                1050                1055    
Gly Val Ala Ser Met Asn Ile Thr Leu Gly Val Pro Arg Ile Lys Glu
            1060                1065                1070        
Ile Ile Asn Ala Ser Lys Ala Ile Ser Thr Pro Ile Ile Thr Ala Gln
        1075                1080                1085            
Leu Asp Lys Asp Asp Asp Ala Asp Tyr Ala Arg Leu Val Lys Gly Arg
    1090                1095                1100                
Ile Glu Lys Thr Leu Leu Gly Glu Ile Ser Glu Tyr Ile Glu Glu Val
1105                1110                1115                1120
Phe Leu Pro Asp Asp Cys Phe Ile Leu Val Lys Leu Ser Leu Glu Arg
                1125                1130                1135    
Ile Arg Leu Leu Arg Leu Glu Val Asn Ala Glu Thr Val Arg Tyr Ser
            1140                1145                1150        
Ile Cys Thr Ser Lys Leu Arg Val Lys Pro Gly Asp Val Ala Val His
        1155                1160                1165            
Gly Glu Ala Val Val Cys Val Thr Pro Arg Glu Asn Ser Lys Ser Ser
    1170                1175                1180                
Met Tyr Tyr Val Leu Gln Phe Leu Lys Glu Asp Leu Pro Lys Val Val
1185                1190                1195                1200
Val Gln Gly Ile Pro Glu Val Ser Arg Ala Val Ile His Ile Asp Glu
                1205                1210                1215    
Gln Ser Gly Lys Glu Lys Tyr Lys Leu Leu Val Glu Gly Asp Asn Leu
            1220                1225                1230        
Arg Ala Val Met Ala Thr His Gly Val Lys Gly Thr Arg Thr Thr Ser
        1235                1240                1245            
Asn Asn Thr Tyr Glu Val Glu Lys Thr Leu Gly Ile Glu Ala Ala Arg
    1250                1255                1260                
Thr Thr Ile Ile Asn Glu Ile Gln Tyr Thr Met Val Val Asn His Gly
1265                1270                1275                1280
Met Ser Ile Asp Arg Arg His Val Met Leu Leu Ser Asp Leu Met Thr
                1285                1290                1295    
Tyr Lys Gly Glu Val Leu Gly Ile Thr Arg Phe Gly Leu Ala Lys Met
            1300                1305                1310        
Lys Glu Ser Val Leu Met Leu Ala Ser Phe Glu Lys Thr Ala Asp His
        1315                1320                1325            
Leu Phe Asp Ala Ala Tyr Phe Gly Gln Lys Asp Ser Val Cys Gly Val
    1330                1335                1340                
Ser Glu Cys Ile Ile Met Gly Ile Pro Met Asn Ile Gly Thr Gly Leu
1345                1350                1355                1360
Phe Lys Leu Leu His Lys Ala Asp Arg Asp Pro Asn Pro Pro Lys Arg
                1365                1370                1375    
Pro Leu Ile Phe Asp Thr Asn Glu Phe His Ile Pro Leu Val Thr
            1380                1385                1390    


<210> 7546
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 7546
Met Val Lys Glu Gln Phe Arg Glu Thr Asp Val Ala Lys Lys Ile Ser
 1               5                  10                  15      
His Ile Cys Phe Gly Met Lys Ser Pro Glu Glu Met Arg Gln Gln Ala
            20                  25                  30          
His Ile Gln Val Val Ser Lys Asn Leu Tyr Ser Gln Asp Asn Gln His
        35                  40                  45              
Ala Pro Leu Leu Tyr Gly Val Leu Asp His Arg Met Gly Thr Ser Glu
    50                  55                  60                  
Lys Asp Arg Pro Cys Glu Thr Cys Gly Lys Asn Leu Ala Asp Cys Leu
65                  70                  75                  80  
Gly His Tyr Gly Tyr Ile Asp Leu Glu Leu Pro Cys Phe His Val Gly
                85                  90                  95      
Tyr Phe Arg Ala Val Ile Gly Ile Leu Gln Met Ile Cys Lys Thr Cys
            100                 105                 110         
Cys His Ile Met Leu Ser Gln Glu Glu Lys Lys Gln Phe Leu Asp Tyr
        115                 120                 125             
Leu Lys Arg Pro Gly Leu Thr Tyr Leu Gln Lys Arg Gly Leu Lys Lys
    130                 135                 140                 
Lys Ile Ser Asp Lys Cys Arg Lys Lys Asn Ile Cys His His Cys Gly
145                 150                 155                 160 
Ala Phe Asn Gly Thr Val Lys Lys Cys Gly Leu Leu Lys Ile Ile His
                165                 170                 175     
Glu Lys Tyr Lys Thr Asn Lys Lys Val Val Asp Pro Ile Val Ser Asn
            180                 185                 190         
Phe Leu Gln Ser Phe Glu Thr Ala Ile Glu His Asn Lys Glu Val Glu
        195                 200                 205             
Pro Leu Leu Gly Arg Ala Gln Glu Asn Leu Asn Pro Leu Val Val Leu
    210                 215                 220                 
Asn Leu Phe Lys Arg Ile Pro Ala Glu Asp Val Pro Leu Leu Leu Met
225                 230                 235                 240 
Asn Pro Glu Ala Gly Lys Pro Ser Asp Leu Ile Leu Thr Arg Leu Leu
                245                 250                 255     
Val Pro Pro Leu Cys Ile Arg Pro Ser Val Val Ser Asp Leu Lys Ser
            260                 265                 270         
Gly Thr Asn Glu Asp Asp Leu Thr Met Lys Leu Thr Glu Ile Ile Phe
        275                 280                 285             
Leu Asn Asp Val Ile Lys Lys His Arg Ile Ser Gly Ala Lys Thr Gln
    290                 295                 300                 
Met Ile Met Glu Asp Trp Asp Phe Leu Gln Leu Gln Cys Ala Leu Tyr
305                 310                 315                 320 
Ile Asn Ser Glu Leu Ser Gly Ile Pro Leu Asn Met Ala Pro Lys Lys
                325                 330                 335     
Trp Thr Arg Gly Phe Val Gln Arg Leu Lys Gly Lys Gln Gly Arg Phe
            340                 345                 350         
Arg Gly Asn Leu Ser Gly Lys Arg Val Asp Phe Ser Gly Arg Thr Val
        355                 360                 365             
Ile Ser Pro Asp Pro Asn Leu Arg Ile Asp Glu Val Ala Val Pro Val
    370                 375                 380                 
His Val Ala Lys Ile Leu Thr Phe Pro Glu Lys Val Asn Lys Ala Asn
385                 390                 395                 400 
Ile Asn Phe Leu Arg Lys Leu Val Gln Asn Gly Pro Glu Val His Pro
                405                 410                 415     
Gly Ala Asn Phe Ile Gln Gln Arg His Thr Gln Met Lys Arg Phe Leu
            420                 425                 430         
Lys Tyr Gly Asn Arg Glu Lys Met Ala Gln Glu Leu Lys Tyr Gly Asp
        435                 440                 445             
Ile Val Glu Arg His Leu Ile Asp Gly Asp Val Val Leu Phe Asn Arg
    450                 455                 460                 
Gln Pro Ser Leu His Lys Leu Ser Ile Met Ala His Leu Ala Arg Val
465                 470                 475                 480 
Lys Pro His Arg Thr Phe Arg Phe Asn Glu Cys Val Cys Thr Pro Tyr
                485                 490                 495     
Asn Ala Asp Phe Asp Gly Asp Glu Met Asn Leu His Leu Pro Gln Thr
            500                 505                 510         
Glu Glu Ala Lys Ala Glu Ala Leu Val Leu Met Gly Thr Lys Ala Asn
        515                 520                 525             
Leu Val Thr Pro Arg Asn Gly Glu Pro Leu Ile Ala Ala Ile Gln Asp
    530                 535                 540                 
Phe Leu Thr Gly Ala Tyr Leu Leu Thr Leu Lys Asp Thr Phe Phe Asp
545                 550                 555                 560 
Arg Ala Lys Ala Cys Gln Ile Ile Ala Ser Ile Leu Val Gly Lys Asp
                565                 570                 575     
Glu Lys Ile Lys Val Arg Leu Pro Pro Pro Thr Ile Leu Lys Pro Val
            580                 585                 590         
Thr Leu Trp Thr Gly Lys Gln Ile Phe Ser Val Ile Leu Arg Pro Ser
        595                 600                 605             
Asp Asp Asn Pro Val Arg Ala Asn Leu Arg Thr Lys Gly Lys Gln Tyr
    610                 615                 620                 
Cys Gly Lys Gly Glu Asp Leu Cys Ala Asn Asp Ser Tyr Val Thr Ile
625                 630                 635                 640 
Gln Asn Ser Glu Leu Met Ser Gly Ser Met Asp Lys Gly Thr Leu Gly
                645                 650                 655     
Ser Gly Ser Lys Asn Asn Ile Phe Tyr Ile Leu Leu Arg Asp Trp Gly
            660                 665                 670         
Gln Asn Glu Ala Ala Asp Ala Met Ser Arg Leu Ala Arg Leu Ala Pro
        675                 680                 685             
Val Tyr Leu Ser Asn Arg Gly Phe Ser Ile Gly Ile Gly Asp Val Thr
    690                 695                 700                 
Pro Gly Gln Gly Leu Leu Lys Ala Lys Tyr Glu Leu Leu Asn Ala Gly
705                 710                 715                 720 
Tyr Lys Lys Cys Asp Glu Tyr Ile Glu Ala Leu Asn Thr Gly Lys Leu
                725                 730                 735     
Gln Gln Gln Pro Gly Cys Thr Ala Glu Glu Thr Leu Glu Ala Leu Ile
            740                 745                 750         
Leu Lys Glu Leu Ser Val Ile Arg Asp His Ala Gly Ser Ala Cys Leu
        755                 760                 765             
Arg Glu Leu Asp Lys Ser Asn Ser Pro Leu Thr Met Ala Leu Cys Gly
    770                 775                 780                 
Ser Lys Gly Ser Phe Ile Asn Ile Ser Gln Met Ile Ala Cys Val Gly
785                 790                 795                 800 
Gln Gln Ala Ile Ser Gly Ser Arg Val Pro Asp Gly Phe Glu Asn Arg
                805                 810                 815     
Ser Leu Pro His Phe Glu Lys His Ser Lys Leu Pro Ala Ala Lys Gly
            820                 825                 830         
Phe Val Ala Asn Ser Phe Tyr Ser Gly Leu Thr Pro Thr Glu Phe Phe
        835                 840                 845             
Phe His Thr Met Ala Gly Arg Glu Gly Leu Val Asp Thr Ala Val Lys
    850                 855                 860                 
Thr Ala Glu Thr Gly Tyr Met Gln Arg Arg Leu Val Lys Ser Leu Glu
865                 870                 875                 880 
Asp Leu Cys Ser Gln Tyr Asp Leu Thr Val Arg Ser Ser Thr Gly Asp
                885                 890                 895     
Ile Ile Gln Phe Ile Tyr Gly Gly Asp Gly Leu Asp Pro Ala Ala Met
            900                 905                 910         
Glu Gly Lys Asp Glu Pro Leu Glu Phe Lys Arg Val Leu Asp Asn Ile
        915                 920                 925             
Lys Ala Val Phe Pro Cys Pro Ser Glu Pro Ala Leu Ser Lys Asn Glu
    930                 935                 940                 
Leu Ile Leu Thr Thr Glu Ser Ile Met Lys Lys Ser Glu Phe Leu Cys
945                 950                 955                 960 
Cys Gln Asp Ser Phe Leu Gln Glu Ile Lys Lys Phe Ile Lys Gly Val
                965                 970                 975     
Ser Glu Lys Ile Lys Lys Thr Arg Asp Lys Tyr Gly Ile Asn Asp Asn
            980                 985                 990         
Gly Thr Thr Glu Pro Arg Val Leu Tyr Gln Leu Asp Arg Ile Thr Pro
        995                 1000                1005            
Thr Gln Val Glu Lys Phe Leu Glu Thr Cys Arg Asp Lys Tyr Met Arg
    1010                1015                1020                
Ala Gln Met Glu Pro Gly Ser Ala Val Gly Ala Leu Cys Ala Gln Ser
1025                1030                1035                1040
Ile Gly Glu Pro Gly Thr Gln Met Thr Leu Lys Thr Phe His Phe Ala
                1045                1050                1055    
Gly Val Ala Ser Met Asn Ile Thr Leu Gly Val Pro Arg Ile Lys Glu
            1060                1065                1070        
Ile Ile Asn Ala Ser Lys Ala Ile Ser Thr Pro Ile Ile Thr Ala Gln
        1075                1080                1085            
Leu Asp Lys Asp Asp Asp Ala Asp Tyr Ala Arg Leu Val Lys Gly Arg
    1090                1095                1100                
Ile Glu Lys Thr Leu Leu Gly Glu Ile Ser Glu Tyr Ile Glu Glu Val
1105                1110                1115                1120
Phe Leu Pro Asp Asp Cys Phe Ile Leu Val Lys Leu Ser Leu Glu Arg
                1125                1130                1135    
Ile Arg Leu Leu Arg Leu Glu Val Asn Ala Glu Thr Val Arg Tyr Ser
            1140                1145                1150        
Ile Cys Thr Ser Lys Leu Arg Val Lys Pro Gly Asp Val Ala Val His
        1155                1160                1165            
Gly Glu Ala Val Val Cys Val Thr Pro Arg Glu Asn Ser Lys Ser Ser
    1170                1175                1180                
Met Tyr Tyr Val Leu Gln Phe Leu Lys Glu Asp Leu Pro Lys Val Val
1185                1190                1195                1200
Val Gln Gly Ile Pro Glu Val Ser Arg Ala Val Ile His Ile Asp Glu
                1205                1210                1215    
Gln Ser Gly Lys Glu Lys Tyr Lys Leu Leu Val Glu Gly Asp Asn Leu
            1220                1225                1230        
Arg Ala Val Met Ala Thr His Gly Val Lys Gly Thr Arg Thr Thr Ser
        1235                1240                1245            
Asn Asn Thr Tyr Glu Val Glu Lys Thr Leu Gly Ile Glu Ala Ala Arg
    1250                1255                1260                
Thr Thr Ile Ile Asn Glu Ile Gln Tyr Thr Met Val Asn His Gly Met
1265                1270                1275                1280
Ser Ile Asp Arg Arg His Val Met Leu Leu Ser Asp Leu Met Thr Tyr
                1285                1290                1295    
Lys Gly Glu Val Leu Gly Ile Thr Arg Phe Gly Leu Ala Lys Met Lys
            1300                1305                1310        
Glu Ser Val Leu Met Leu Ala Ser Phe Glu Lys Thr Ala Asp His Leu
        1315                1320                1325            
Phe Asp Ala Ala Tyr Phe Gly Gln Lys Asp Ser Val Cys Gly Val Ser
    1330                1335                1340                
Glu Cys Ile Ile Met Gly Ile Pro Met Asn Ile Gly Thr Gly Leu Phe
1345                1350                1355                1360
Lys Leu Leu His Lys Ala Asp Arg Asp Pro Asn Pro Pro Lys Arg Pro
                1365                1370                1375    
Leu Ile Phe Asp Thr Asn Glu Phe His Ile Pro Leu Val Thr
            1380                1385                1390


<210> 7547
<211> 252
<212> PRT
<213> Homo sapiens

<400> 7547
Met Phe Gln Pro Ala Pro Lys Arg Cys Phe Thr Ile Glu Ser Leu Val
 1               5                  10                  15      
Ala Lys Asp Ser Pro Leu Pro Ala Ser Arg Ser Glu Asp Pro Ile Arg
            20                  25                  30          
Pro Ala Ala Leu Ser Tyr Ala Asn Ser Ser Pro Ile Asn Pro Phe Leu
        35                  40                  45              
Asn Gly Phe His Ser Ala Ala Ala Ala Ala Ala Gly Arg Gly Val Tyr
    50                  55                  60                  
Ser Asn Pro Asp Leu Val Phe Ala Glu Ala Val Ser His Pro Pro Asn
65                  70                  75                  80  
Pro Ala Val Pro Val His Pro Val Pro Pro Pro His Ala Leu Ala Ala
                85                  90                  95      
His Pro Leu Pro Ser Ser His Ser Pro His Pro Leu Phe Ala Ser Gln
            100                 105                 110         
Gln Arg Asp Pro Ser Thr Phe Tyr Pro Trp Leu Ile His Arg Tyr Arg
        115                 120                 125             
Tyr Leu Gly His Arg Phe Gln Gly Asn Asp Thr Ser Pro Glu Ser Phe
    130                 135                 140                 
Leu Leu His Asn Ala Leu Ala Arg Lys Pro Lys Arg Ile Arg Thr Ala
145                 150                 155                 160 
Phe Ser Pro Ser Gln Leu Leu Arg Leu Glu His Ala Phe Glu Lys Asn
                165                 170                 175     
His Tyr Val Val Gly Ala Glu Arg Lys Gln Leu Ala His Ser Leu Ser
            180                 185                 190         
Leu Thr Glu Thr Gln Val Lys Val Trp Phe Gln Asn Arg Arg Thr Lys
        195                 200                 205             
Phe Lys Arg Gln Lys Leu Glu Glu Glu Gly Ser Asp Ser Gln Gln Lys
    210                 215                 220                 
Lys Lys Gly Thr His His Ile Asn Arg Trp Arg Ile Ala Thr Lys Gln
225                 230                 235                 240 
Ala Ser Pro Glu Glu Ile Asp Val Thr Ser Asp Asp
                245                 250         


<210> 7548
<211> 215
<212> PRT
<213> Homo sapiens

<400> 7548
Gln Val Val Met Arg Phe Asn Asn Ser Leu Leu Pro Thr Glu Pro Ser
 1               5                  10                  15      
Gln Gln Leu Gln Ala Tyr Val Ala Trp Val Asn Ala Gln Leu Lys Lys
            20                  25                  30          
Arg Pro Ala Val Lys Pro Val Gln Asp Leu Arg Gln Asp Leu Arg Asp
        35                  40                  45              
Gly Val Ile Leu Ala Tyr Leu Ile Glu Ile Val Ala Gly Glu Lys Leu
    50                  55                  60                  
Ser Gly Val Gln Leu Ser Pro Gly Asn Gln Gln Glu Met Lys Asn Asn
65                  70                  75                  80  
Val Glu Lys Val Leu Gln Phe Val Ala Ser Lys Lys Ile Arg Met His
                85                  90                  95      
Gln Thr Ser Ala Lys Asp Ile Val Asp Gly Asn Leu Lys Ser Ile Met
            100                 105                 110         
Arg Leu Val Leu Ala Leu Ala Ala His Phe Lys Pro Gly Ser Ser Arg
        115                 120                 125             
Thr Val Asn Gln Gly Arg Asp Ser Arg Ala Pro Leu Gln Ser His Arg
    130                 135                 140                 
Pro His Cys Ala Thr Ala Val Ala Gln Gly Ala Ala Ala Ala Leu Ala
145                 150                 155                 160 
Asp Val Cys His Asp Met Ser Arg Ser Gly Arg Asp Val Phe Arg Tyr
                165                 170                 175     
Arg Gln Arg Asn Ser Ser Met Asp Glu Glu Ile Glu Asn Pro Tyr Trp
            180                 185                 190         
Ser Val Arg Ala Leu Val Gln Gln Tyr Glu Gly Gln Gln Arg Ser Pro
        195                 200                 205             
Ser Glu Ser Ser Cys Ser Arg
    210                 215 


<210> 7549
<211> 565
<212> PRT
<213> Homo sapiens

<400> 7549
His His His His His His Arg Ala Gln Pro Pro Gln Gln Ser His His
 1               5                  10                  15      
Pro Pro His His His Arg Pro Gln Pro His Leu Gly Ser Phe Pro Glu
            20                  25                  30          
Ser Cys Ser Ser Asp Ser Glu Ser Ser Ser Tyr Ser Asp His Ala Ala
        35                  40                  45              
Asn Asp Ser Asp Phe Gly Ser Ser Leu Ser Ser Ser Ser Asn Ser Val
    50                  55                  60                  
Ser Ser Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu
65                  70                  75                  80  
Glu Glu Glu Glu Glu Gly Gly Ser Gly Ala Ser Asp Ser Ser Glu Val
                85                  90                  95      
Ser Ser Glu Glu Glu Asp Ser Ser Thr Glu Ser Asp Ser Ser Ser Gly
            100                 105                 110         
Ser Ser Gln Val Ser Val Gln Ser Ile Arg Phe Arg Arg Thr Ser Phe
        115                 120                 125             
Cys Lys Pro Pro Ser Val Gln Ala Gln Ala Asn Phe Leu Tyr His Leu
    130                 135                 140                 
Ala Ser Ala Ala Ala Ala Thr Lys Pro Ala Ala Phe Glu Asp Ala Gly
145                 150                 155                 160 
Arg Leu Pro Asp Leu Lys Ser Ser Val Lys Ala Glu Ser Pro Ala Glu
                165                 170                 175     
Trp Asn Leu Gln Ser Trp Ala Pro Lys Ala Ser Pro Val Tyr Cys Pro
            180                 185                 190         
Ala Ser Leu Gly Ser Cys Phe Ala Glu Ile Arg Asn Asp Arg Val Ser
        195                 200                 205             
Glu Ile Thr Phe Pro His Ser Glu Ile Ser Asn Ala Val Lys Arg Thr
    210                 215                 220                 
Asp Leu Thr Ile Asn Cys Leu Ala Glu Gly Ala Ser Ser Pro Ser Pro
225                 230                 235                 240 
Lys Thr Asn Asn Ala Phe Pro Gln Gln Arg Ile Leu Arg Glu Ala Arg
                245                 250                 255     
Lys Cys Leu Gln Thr Thr Pro Thr Thr His Cys Ala Asp Asn Asn Thr
            260                 265                 270         
Ile Ala Ala Arg Phe Leu Asn Asn Asp Ser Ser Gly Ala Glu Ala Asn
        275                 280                 285             
Ser Glu Lys Tyr Ser Lys Ile Leu His Cys Pro Glu Phe Ala Thr Asp
    290                 295                 300                 
Leu Pro Ser Ser Gln Thr Asp Pro Glu Val Asn Ala Ala Gly Ala Ala
305                 310                 315                 320 
Ala Thr Lys Ala Glu Asn Pro Cys Thr Asp Thr Gly Asp Lys Thr Leu
                325                 330                 335     
Pro Phe Leu His Asn Ile Lys Ile Lys Val Glu Asp Ser Ser Ala Asn
            340                 345                 350         
Glu Glu Tyr Glu Pro His Leu Phe Thr Asn Lys Leu Lys Cys Glu Cys
        355                 360                 365             
Asn Asp Thr Lys Gly Glu Phe Tyr Ser Val Thr Glu Ser Lys Glu Glu
    370                 375                 380                 
Asp Ala Leu Leu Thr Thr Ala Lys Glu Gly Phe Ala Cys Pro Glu Lys
385                 390                 395                 400 
Glu Thr Pro Ser Leu Asn Pro Leu Ala Gln Ser Gln Gly Leu Ser Cys
                405                 410                 415     
Thr Leu Gly Ser Pro Lys Pro Glu Asp Gly Glu Tyr Lys Phe Gly Ala
            420                 425                 430         
Arg Val Arg Lys Asn Tyr Arg Thr Leu Val Leu Gly Lys Arg Pro Val
        435                 440                 445             
Leu Gln Thr Pro Pro Val Lys Pro Asn Leu Lys Ser Ala Arg Ser Pro
    450                 455                 460                 
Arg Pro Thr Gly Lys Thr Glu Thr Asn Glu Gly Thr Leu Asp Asp Phe
465                 470                 475                 480 
Thr Val Ile Asn Arg Arg Lys Lys Val Ala Ser Asn Val Ala Ser Ala
                485                 490                 495     
Val Lys Arg Pro Phe His Phe Met Ala Asn Phe Pro Cys Pro Pro Ser
            500                 505                 510         
Leu Ile Ile Gly Arg Asp Gly Asp Leu Trp Pro Ala Tyr Ser Leu Asn
        515                 520                 525             
Thr Thr Lys Asp Ser Gln Thr Pro His Lys Ala His Pro Ile Trp Lys
    530                 535                 540                 
Trp Gln Leu Gly Gly Ser Ala Ile Pro Leu Pro Pro Ser His Lys Phe
545                 550                 555                 560 
Arg Lys Phe Asn Ser
                565 


<210> 7550
<211> 941
<212> PRT
<213> Homo sapiens

<400> 7550
Met Tyr Gln Gly Glu Phe Gly Leu Asn Met Lys Leu Gly Tyr Gly Lys
 1               5                  10                  15      
Phe Ser Trp Pro Thr Gly Glu Ser Tyr His Gly Gln Phe Tyr Arg Asp
            20                  25                  30          
His Cys His Gly Leu Gly Thr Tyr Met Trp Pro Asp Gly Ser Ser Phe
        35                  40                  45              
Thr Gly Thr Phe Tyr Leu Ser His Arg Glu Gly Tyr Gly Thr Met Tyr
    50                  55                  60                  
Met Lys Thr Arg Leu Phe Gln Gly Leu Tyr Lys Ala Asp Gln Arg Phe
65                  70                  75                  80  
Gly Pro Gly Val Glu Thr Tyr Pro Asp Gly Ser Gln Asp Val Gly Leu
                85                  90                  95      
Trp Phe Arg Glu Gln Leu Ile Lys Leu Cys Thr Gln Ile Pro Ser Gly
            100                 105                 110         
Phe Ser Leu Leu Arg Tyr Pro Glu Phe Ser Ser Phe Ile Thr His Ser
        115                 120                 125             
Pro Ala Arg Ile Ser Leu Ser Glu Glu Glu Lys Thr Glu Trp Gly Leu
    130                 135                 140                 
Gln Glu Gly Gln Asp Pro Phe Phe Tyr Asp Tyr Lys Arg Phe Leu Leu
145                 150                 155                 160 
Asn Asp Asn Leu Thr Leu Pro Pro Glu Met Tyr Val Tyr Ser Thr Asn
                165                 170                 175     
Ser Asp His Leu Pro Met Thr Ser Ser Phe Arg Lys Glu Leu Asp Ala
            180                 185                 190         
Arg Ile Phe Leu Asn Glu Ile Pro Pro Phe Val Glu Asp Gly Glu Pro
        195                 200                 205             
Trp Phe Ile Ile Asn Glu Thr Pro Leu Leu Val Lys Ile Gln Lys Gln
    210                 215                 220                 
Thr Tyr Lys Phe Arg Asn Lys Pro Ala His Thr Ser Trp Asn Met Gly
225                 230                 235                 240 
Ala Ile Leu Glu Gly Lys Arg Ser Gly Phe Ala Pro Cys Gly Pro Lys
                245                 250                 255     
Glu Gln Leu Ser Met Glu Met Ile Leu Lys Ala Glu Glu Gly Asn His
            260                 265                 270         
Glu Trp Ile Cys Arg Ile Leu Lys Asp Asn Phe Ala Ser Ala Asp Val
        275                 280                 285             
Ala Asp Ala Lys Gly Tyr Thr Val Leu Ala Ala Ala Ala Thr His Cys
    290                 295                 300                 
His Asn Asp Ile Val Asn Leu Leu Leu Asp Cys Gly Ala Asp Val Asn
305                 310                 315                 320 
Lys Cys Ser Asp Glu Gly Leu Thr Ala Leu Ser Met Cys Phe Leu Leu
                325                 330                 335     
His Tyr Pro Ala Gln Ser Phe Lys Pro Asn Val Ala Glu Arg Thr Ile
            340                 345                 350         
Pro Glu Pro Gln Glu Pro Pro Lys Phe Pro Val Val Pro Ile Leu Ser
        355                 360                 365             
Ser Ser Phe Met Asp Thr Asn Leu Glu Ser Leu Tyr Tyr Glu Val Asn
    370                 375                 380                 
Val Pro Ser Gln Gly Ser Tyr Glu Leu Arg Pro Pro Pro Ala Pro Leu
385                 390                 395                 400 
Leu Leu Pro Arg Val Ser Gly Ser His Glu Gly Gly His Phe Gln Asp
                405                 410                 415     
Thr Gly Gln Cys Gly Gly Ser Ile Asp His Arg Ser Ser Ser Leu Lys
            420                 425                 430         
Gly Asp Ser Pro Leu Val Lys Gly Ser Leu Gly His Val Glu Ser Gly
        435                 440                 445             
Leu Glu Asp Val Leu Gly Asn Thr Asp Arg Gly Ser Leu Cys Ser Ala
    450                 455                 460                 
Glu Thr Lys Phe Glu Ser Asn Val Cys Val Cys Asp Phe Ser Ile Glu
465                 470                 475                 480 
Leu Ser Gln Ala Met Leu Glu Arg Ser Ala Gln Ser His Ser Leu Leu
                485                 490                 495     
Lys Met Ala Ser Pro Ser Pro Cys Thr Ser Ser Phe Asp Lys Gly Thr
            500                 505                 510         
Met Arg Arg Met Ala Leu Ser Met Ile Glu Arg Arg Lys Arg Trp Arg
        515                 520                 525             
Thr Ile Lys Leu Leu Leu Arg Arg Gly Ala Asp Pro Asn Leu Cys Cys
    530                 535                 540                 
Val Pro Met Gln Val Leu Phe Leu Ala Val Lys Ala Gly Asp Val Asp
545                 550                 555                 560 
Gly Val Arg Leu Leu Leu Glu His Gly Ala Arg Thr Asp Ile Cys Phe
                565                 570                 575     
Pro Pro Gln Leu Ser Thr Leu Thr Pro Leu His Ile Ala Ala Ala Leu
            580                 585                 590         
Pro Gly Glu Glu Gly Val Gln Ile Val Glu Leu Leu Leu His Ala Ile
        595                 600                 605             
Thr Asp Val Asp Ala Lys Ala Ser Asp Glu Asp Asp Thr Tyr Lys Pro
    610                 615                 620                 
Gly Lys Leu Asp Leu Leu Pro Ser Ser Leu Lys Leu Ser Asn Glu Pro
625                 630                 635                 640 
Gly Pro Pro Gln Ala Tyr Tyr Ser Thr Asp Thr Ala Leu Pro Glu Glu
                645                 650                 655     
Gly Gly Arg Thr Ala Leu His Met Ala Cys Glu Arg Glu Asp Asp Asn
            660                 665                 670         
Lys Cys Ala Arg Asp Ile Val Arg Leu Leu Leu Ser His Gly Ala Asn
        675                 680                 685             
Pro Asn Leu Leu Trp Ser Gly His Ser Pro Leu Ser Leu Ser Ile Ala
    690                 695                 700                 
Ser Gly Asn Glu Leu Val Val Lys Glu Leu Leu Thr Gln Gly Ala Asp
705                 710                 715                 720 
Pro Asn Leu Pro Leu Thr Lys Gly Leu Gly Ser Ala Leu Cys Val Ala
                725                 730                 735     
Cys Asp Leu Thr Tyr Glu His Gln Arg Asn Met Asp Ser Lys Leu Ala
            740                 745                 750         
Leu Ile Asp Arg Leu Ile Ser His Gly Ala Asp Ile Leu Lys Pro Val
        755                 760                 765             
Met Leu Arg Gln Gly Glu Lys Glu Ala Val Gly Thr Ala Val Asp Tyr
    770                 775                 780                 
Gly Tyr Phe Arg Phe Phe Gln Asp Arg Arg Ile Ala Arg Cys Pro Phe
785                 790                 795                 800 
His Thr Leu Met Pro Ala Glu Arg Glu Thr Phe Leu Ala Arg Lys Arg
                805                 810                 815     
Leu Leu Glu Tyr Met Gly Leu Gln Leu Arg Gln Ala Val Phe Ala Lys
            820                 825                 830         
Glu Ser Gln Trp Asp Pro Thr Trp Leu Tyr Leu Cys Lys Arg Ala Glu
        835                 840                 845             
Leu Ile Pro Ser His Arg Met Lys Lys Lys Gly Pro Ser Leu Pro Arg
    850                 855                 860                 
Gly Leu Asp Val Lys Glu Gln Gly Gln Ile Pro Phe Phe Lys Phe Cys
865                 870                 875                 880 
Tyr Gln Cys Gly Arg Ser Ile Gly Val Arg Leu Leu Pro Cys Pro Arg
                885                 890                 895     
Cys Tyr Gly Ile Leu Thr Cys Ser Lys Tyr Cys Lys Thr Lys Ala Trp
            900                 905                 910         
Thr Glu Phe His Lys Lys Asp Cys Gly Asp Leu Val Ala Ile Val Thr
        915                 920                 925             
Gln Leu Glu Gln Val Ser Arg Arg Arg Glu Glu Phe Gln
    930                 935                 940     


<210> 7551
<211> 148
<212> PRT
<213> Homo sapiens

<400> 7551
Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His
 1               5                  10                  15      
Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr
            20                  25                  30          
Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val
        35                  40                  45              
Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr
    50                  55                  60                  
Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val
65                  70                  75                  80  
Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro
                85                  90                  95      
Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Lys Arg
            100                 105                 110         
Arg Gly Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu Glu Lys Tyr Arg
        115                 120                 125             
Pro Lys Gln Arg Leu Arg Phe Lys Asp Pro His Thr His Lys Thr Arg
    130                 135                 140                 
Cys Cys Val Met
145             


<210> 7552
<211> 87
<212> PRT
<213> Homo sapiens

<400> 7552
Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His
 1               5                  10                  15      
Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr
            20                  25                  30          
Phe Ile Glu Asp Leu Lys Lys Tyr Glu Asp Ala Ile Gln Phe Ile Arg
        35                  40                  45              
Gln Lys Arg Arg Gly Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu Glu
    50                  55                  60                  
Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe Lys Asp Pro His Thr His
65                  70                  75                  80  
Lys Thr Arg Cys Cys Val Met
                85          


<210> 7553
<211> 173
<212> PRT
<213> Homo sapiens

<400> 7553
Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His
 1               5                  10                  15      
Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr
            20                  25                  30          
Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val
        35                  40                  45              
Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr
    50                  55                  60                  
Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val
65                  70                  75                  80  
Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro
                85                  90                  95      
Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro
            100                 105                 110         
Val Leu Val Ala Leu Ala Leu Ile Glu Ser Gly Met Lys Tyr Glu Asp
        115                 120                 125             
Ala Ile Gln Phe Ile Arg Gln Lys Arg Arg Gly Arg Ile Asn Ser Lys
    130                 135                 140                 
Gln Leu Thr Tyr Leu Glu Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe
145                 150                 155                 160 
Lys Asp Pro His Thr His Lys Thr Arg Cys Cys Val Met
                165                 170             


<210> 7554
<211> 469
<212> PRT
<213> Homo sapiens

<400> 7554
Met Phe Ser Glu Gln Ala Ala Gln Arg Ala His Thr Leu Leu Ser Pro
 1               5                  10                  15      
Pro Ser Ala Asn Asn Ala Thr Phe Ala Arg Val Pro Val Ala Thr Tyr
            20                  25                  30          
Thr Asn Ser Ser Gln Pro Phe Arg Leu Gly Glu Arg Ser Phe Ser Arg
        35                  40                  45              
Gln Tyr Ala His Ile Tyr Ala Thr Arg Leu Ile Gln Met Arg Pro Phe
    50                  55                  60                  
Leu Glu Asn Arg Ala Gln Gln His Trp Gly Ser Gly Val Gly Val Lys
65                  70                  75                  80  
Lys Leu Cys Glu Leu Gln Pro Glu Glu Lys Cys Cys Val Val Gly Thr
                85                  90                  95      
Leu Phe Lys Ala Met Pro Leu Gln Pro Ser Ile Leu Arg Glu Val Ser
            100                 105                 110         
Glu Glu His Asn Leu Leu Pro Gln Pro Pro Arg Ser Lys Tyr Ile His
        115                 120                 125             
Pro Asp Asp Glu Leu Val Leu Glu Asp Glu Leu Gln Arg Ile Lys Leu
    130                 135                 140                 
Lys Gly Thr Ile Asp Val Ser Lys Leu Val Thr Gly Thr Val Leu Ala
145                 150                 155                 160 
Val Phe Gly Ser Val Arg Asp Asp Gly Lys Phe Leu Val Glu Asp Tyr
                165                 170                 175     
Cys Phe Ala Asp Leu Ala Pro Gln Lys Pro Ala Pro Pro Leu Asp Thr
            180                 185                 190         
Asp Arg Phe Val Leu Leu Val Ser Gly Leu Gly Leu Gly Gly Gly Gly
        195                 200                 205             
Gly Glu Ser Leu Leu Gly Thr Gln Leu Leu Val Asp Val Val Thr Gly
    210                 215                 220                 
Gln Leu Gly Asp Glu Gly Glu Gln Cys Ser Ala Ala His Val Ser Arg
225                 230                 235                 240 
Val Ile Leu Ala Gly Asn Leu Leu Ser His Ser Thr Gln Ser Arg Asp
                245                 250                 255     
Ser Ile Asn Lys Ala Lys Tyr Leu Thr Lys Lys Thr Gln Ala Ala Ser
            260                 265                 270         
Val Glu Ala Val Lys Met Leu Asp Glu Ile Leu Leu Gln Leu Ser Ala
        275                 280                 285             
Ser Val Pro Val Asp Val Met Pro Gly Glu Phe Asp Pro Thr Asn Tyr
    290                 295                 300                 
Thr Leu Pro Gln Gln Pro Leu His Pro Cys Met Phe Pro Leu Ala Thr
305                 310                 315                 320 
Ala Tyr Ser Thr Leu Gln Leu Val Thr Asn Pro Tyr Gln Ala Thr Ile
                325                 330                 335     
Asp Gly Val Arg Phe Leu Gly Thr Ser Gly Gln Asn Val Ser Asp Ile
            340                 345                 350         
Phe Arg Tyr Ser Ser Met Glu Asp His Leu Glu Ile Leu Glu Trp Thr
        355                 360                 365             
Leu Arg Val Arg His Ile Ser Pro Thr Ala Pro Asp Thr Leu Gly Cys
    370                 375                 380                 
Tyr Pro Phe Tyr Lys Thr Asp Pro Phe Ile Phe Pro Glu Cys Pro His
385                 390                 395                 400 
Val Tyr Phe Cys Gly Asn Thr Pro Ser Phe Gly Ser Lys Ile Ile Arg
                405                 410                 415     
Gly Pro Glu Asp Gln Thr Val Leu Leu Val Thr Val Pro Asp Phe Ser
            420                 425                 430         
Ala Thr Gln Thr Ala Cys Leu Val Asn Leu Arg Ser Leu Ala Cys Gln
        435                 440                 445             
Pro Ile Ser Phe Ser Gly Phe Gly Ala Glu Asp Asp Asp Leu Gly Gly
    450                 455                 460                 
Leu Gly Leu Gly Pro
465                 


<210> 7555
<211> 144
<212> PRT
<213> Homo sapiens

<400> 7555
Met Arg Lys Ile Asp Leu Cys Leu Ser Ser Glu Gly Ser Glu Val Ile
 1               5                  10                  15      
Leu Ala Thr Ser Ser Asp Glu Lys His Pro Pro Glu Asn Ile Ile Asp
            20                  25                  30          
Gly Asn Pro Glu Thr Phe Trp Thr Thr Thr Gly Met Phe Pro Gln Glu
        35                  40                  45              
Phe Ile Ile Cys Phe His Lys His Val Arg Ile Glu Arg Leu Val Ile
    50                  55                  60                  
Gln Ser Tyr Phe Val Gln Thr Leu Lys Ile Glu Lys Ser Thr Ser Lys
65                  70                  75                  80  
Glu Pro Val Asp Phe Glu Gln Trp Ile Glu Lys Asp Leu Val His Thr
                85                  90                  95      
Glu Gly Gln Leu Gln Asn Glu Glu Ile Val Ala His Asp Gly Ser Ala
            100                 105                 110         
Thr Tyr Leu Arg Phe Ile Ile Val Ser Ala Phe Asp His Phe Ala Ser
        115                 120                 125             
Val His Ser Val Ser Ala Glu Gly Thr Val Val Ser Asn Leu Ser Ser
    130                 135                 140                 


<210> 7556
<211> 459
<212> PRT
<213> Homo sapiens

<400> 7556
Met Ser Asn Cys Leu Gln Asn Phe Leu Lys Ile Thr Ser Thr Arg Leu
 1               5                  10                  15      
Leu Cys Ser Arg Leu Cys Gln Gln Leu Arg Ser Lys Arg Lys Phe Phe
            20                  25                  30          
Gly Thr Val Pro Ile Ser Arg Leu His Arg Arg Val Val Ile Thr Gly
        35                  40                  45              
Ile Gly Leu Val Thr Pro Leu Gly Val Gly Thr His Leu Val Trp Asp
    50                  55                  60                  
Arg Leu Ile Gly Gly Glu Ser Gly Ile Val Ser Leu Val Gly Glu Glu
65                  70                  75                  80  
Tyr Lys Ser Ile Pro Cys Ser Val Ala Ala Tyr Val Pro Arg Gly Ser
                85                  90                  95      
Asp Glu Gly Gln Phe Asn Glu Gln Asn Phe Val Ser Lys Ser Asp Ile
            100                 105                 110         
Lys Ser Met Ser Ser Pro Thr Ile Met Ala Ile Gly Ala Ala Glu Leu
        115                 120                 125             
Ala Met Lys Asp Ser Gly Trp His Pro Gln Ser Glu Ala Asp Gln Val
    130                 135                 140                 
Ala Thr Gly Val Ala Ile Gly Met Gly Met Ile Pro Leu Glu Val Val
145                 150                 155                 160 
Ser Glu Thr Ala Leu Asn Phe Gln Thr Lys Gly Tyr Asn Lys Val Ser
                165                 170                 175     
Pro Phe Phe Val Pro Lys Ile Leu Val Asn Met Ala Ala Gly Gln Val
            180                 185                 190         
Ser Ile Arg Tyr Lys Leu Lys Gly Pro Asn His Ala Val Ser Thr Ala
        195                 200                 205             
Cys Thr Thr Gly Ala His Ala Val Gly Asp Ser Phe Arg Phe Ile Ala
    210                 215                 220                 
His Gly Asp Ala Asp Val Met Val Ala Gly Gly Thr Asp Ser Cys Ile
225                 230                 235                 240 
Ser Pro Leu Ser Leu Ala Gly Phe Ser Arg Ala Arg Ala Leu Ser Thr
                245                 250                 255     
Asn Ser Asp Pro Lys Leu Ala Cys Arg Pro Phe His Pro Lys Arg Asp
            260                 265                 270         
Gly Phe Val Met Gly Glu Gly Ala Ala Val Leu Val Leu Glu Glu Tyr
        275                 280                 285             
Glu His Ala Val Gln Arg Arg Ala Arg Ile Tyr Ala Glu Val Leu Gly
    290                 295                 300                 
Tyr Gly Leu Ser Gly Asp Ala Gly His Ile Thr Ala Pro Asp Pro Glu
305                 310                 315                 320 
Gly Glu Gly Ala Leu Arg Cys Met Ala Ala Ala Leu Lys Asp Ala Gly
                325                 330                 335     
Val Gln Pro Glu Glu Ile Ser Tyr Ile Asn Ala His Ala Thr Ser Thr
            340                 345                 350         
Pro Leu Gly Asp Ala Ala Glu Asn Lys Ala Ile Lys His Leu Phe Lys
        355                 360                 365             
Asp His Ala Tyr Ala Leu Ala Val Ser Ser Thr Lys Gly Ala Thr Gly
    370                 375                 380                 
His Leu Leu Gly Ala Ala Gly Ala Val Glu Ala Ala Phe Thr Thr Leu
385                 390                 395                 400 
Ala Cys Tyr Tyr Gln Lys Leu Pro Pro Thr Leu Asn Leu Asp Cys Ser
                405                 410                 415     
Glu Pro Glu Phe Asp Leu Asn Tyr Val Pro Leu Lys Ala Gln Glu Trp
            420                 425                 430         
Lys Thr Glu Lys Arg Phe Ile Gly Leu Thr Asn Ser Phe Gly Phe Gly
        435                 440                 445             
Gly Thr Asn Ala Thr Leu Cys Ile Ala Gly Leu
    450                 455                 


<210> 7557
<211> 293
<212> PRT
<213> Homo sapiens

<400> 7557
Met Asn Ala Gly Val Glu Ala Asp Ser Ala Ser Leu Pro Val Leu Leu
 1               5                  10                  15      
Glu Pro Phe Val Gly Ser Cys Val Ser Ser Ala Asn Ala Pro Glu Lys
            20                  25                  30          
Ser Ile Thr Arg Pro Glu Phe Glu Ser Ser Cys Phe Phe Met Trp Ser
        35                  40                  45              
Trp Glu Gln Ala Gln Leu Trp Ala Leu Ile Leu Leu Leu Glu Glu Arg
    50                  55                  60                  
Arg Arg Glu Lys Ser Asp Val Ala Ala Asn Gln Gly Ser Asp Leu Ile
65                  70                  75                  80  
Ser Tyr Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala Lys Ala
                85                  90                  95      
Lys His Val Val Val Ile Ser Gly Ala Asp Val Ile Ala Val Ser Gly
            100                 105                 110         
Val Pro Pro Phe Arg Gln Ala Gly Gly His Gly Glu Asn Val Ser Pro
        115                 120                 125             
Gly Pro Gly Ser Ser Ser Val Leu Cys Pro Arg Phe Ser Gly Cys Gly
    130                 135                 140                 
Ser Ser Pro Leu Arg Val Arg Gly Gln Ala Glu Gln Glu Pro Ser Pro
145                 150                 155                 160 
His Leu Ala Thr Ile Glu Cys Asp Ala Leu Leu Gly Gly Gln Gly Arg
                165                 170                 175     
Gln Gly Met Ile Met Thr Glu Tyr Pro Trp Ala Ala Pro Lys Ala Gly
            180                 185                 190         
Ala Lys Asn Leu Leu Glu Ile His Cys Ser Leu Phe Lys Leu His Val
        195                 200                 205             
Pro Leu Val Glu Ser Cys Leu Arg Ile Met Arg Val Glu Ala Glu Ser
    210                 215                 220                 
Arg Gly Leu Pro Gln Pro His Ala Leu Trp Phe Gly Lys Asn Leu Asp
225                 230                 235                 240 
Pro Ala Phe Leu Glu Glu Met Ser Ala Lys Gly Val Pro Val Thr Glu
                245                 250                 255     
Phe Asn Met Glu Thr Thr Ser Ala Met Arg Arg Phe Arg Phe His Phe
            260                 265                 270         
Gln Gly Pro Cys Gly Arg Met Leu Pro Glu Pro Leu Ala Gly His Glu
        275                 280                 285             
Asn Glu Thr Val Ser
    290             


<210> 7558
<211> 508
<212> PRT
<213> Homo sapiens

<400> 7558
Met Ile Met Ser Asn Thr His Lys Ala Arg Leu Glu Arg Arg Val Thr
 1               5                  10                  15      
Gly Ser Thr Asn Arg Trp Arg Leu Pro Lys Gln Pro Phe Ser Gly Asp
            20                  25                  30          
Leu Leu Ser Leu Ser Gln Met Cys Lys Ala Leu Ser Ile Asp Phe Glu
        35                  40                  45              
Glu Ala Leu Arg Asn Pro Asp Arg Leu Cys Ile Ser Gln Ile Gln Lys
    50                  55                  60                  
Phe Phe Phe Glu Asn Phe Lys Asn Lys Asp Ile Gln Ser Gly Glu Ala
65                  70                  75                  80  
Asp Val Ile Leu Glu Cys Leu Gly Phe Lys Trp Glu Leu His Gln Pro
                85                  90                  95      
Gln Leu Phe Gln Ser Glu Thr Leu Ala Lys Leu Tyr Leu Lys Ala Leu
            100                 105                 110         
Ala Gln Gly Thr Thr His Pro Leu Arg Glu Leu Glu Glu Leu Leu Arg
        115                 120                 125             
Ala Gln Ser Pro Lys Lys Thr Lys Glu Lys Ser Pro Ala Lys Arg Ile
    130                 135                 140                 
Ile Ile Ser Leu Lys Ile Asn Asp Pro Leu Val Thr Lys Val Ala Phe
145                 150                 155                 160 
Ala Thr Ala Leu Lys Asn Leu Tyr Met Ser Glu Val Glu Ile Asn Leu
                165                 170                 175     
Glu Asp Leu Leu Gly Val Leu Ala Ser Ala His Ile Leu Gln Phe Ser
            180                 185                 190         
Gly Leu Phe Gln Arg Cys Val Asp Val Met Ile Ala Arg Leu Lys Pro
        195                 200                 205             
Ser Thr Ile Lys Lys Phe Tyr Glu Ala Gly Cys Lys Tyr Lys Glu Glu
    210                 215                 220                 
Gln Leu Thr Thr Gly Cys Glu Lys Trp Leu Glu Met Asn Leu Val Pro
225                 230                 235                 240 
Leu Gly Gly Thr Gln Ile His Leu His Lys Ile Pro Gln Asp Leu Leu
                245                 250                 255     
His Lys Val Leu Lys Ser Pro Arg Leu Phe Thr Phe Ser Glu Phe His
            260                 265                 270         
Leu Leu Lys Thr Met Leu Leu Trp Val Phe Leu Gln Leu Asn Tyr Lys
        275                 280                 285             
Ile Gln Ala Ile Pro Thr Tyr Glu Thr Val Met Thr Phe Phe Lys Ser
    290                 295                 300                 
Phe Pro Glu Asn Cys Cys Phe Leu Asp Arg Asp Ile Gly Arg Ser Leu
305                 310                 315                 320 
Arg Pro Leu Phe Leu Cys Leu Arg Leu His Gly Ile Thr Lys Gly Lys
                325                 330                 335     
Asp Leu Glu Val Leu Arg His Leu Asn Phe Phe Pro Glu Ser Trp Leu
            340                 345                 350         
Asp Gln Val Thr Val Asn His Tyr His Ala Leu Glu Asn Gly Gly Asp
        355                 360                 365             
Met Val His Leu Lys Asp Leu Asn Thr Gln Ala Val Arg Phe Gly Leu
    370                 375                 380                 
Leu Phe Asn Gln Glu Asn Thr Thr Tyr Ser Lys Thr Ile Ala Leu Tyr
385                 390                 395                 400 
Gly Phe Phe Phe Lys Ile Lys Gly Leu Lys His Asp Thr Thr Ser Tyr
                405                 410                 415     
Ser Phe Tyr Met Gln Arg Ile Lys His Thr Asp Leu Glu Ser Pro Ser
            420                 425                 430         
Ala Val Tyr Glu His Asn His Val Ser Leu Arg Ala Ala Arg Leu Val
        435                 440                 445             
Lys Tyr Glu Ile Arg Ala Glu Ala Leu Val Asp Gly Lys Trp Gln Glu
    450                 455                 460                 
Phe Arg Thr Asn Gln Ile Lys Gln Lys Phe Gly Leu Thr Thr Ser Ser
465                 470                 475                 480 
Cys Lys Ser His Ala Ser Thr Leu Lys Ile Gln Thr Val Gly Ile Pro
                485                 490                 495     
Ile Tyr Val Ser Phe Ala Phe Ile Phe Pro Ala Ser
            500                 505             


<210> 7559
<211> 919
<212> PRT
<213> Homo sapiens

<400> 7559
Met Asp Val Gly Phe Ser Arg Thr Thr Val Gln Thr Leu Ser Arg Ser
 1               5                  10                  15      
His Cys Lys Asn Ile Lys Gln Lys Ile Ser Gln Trp Glu Gly Arg Ala
            20                  25                  30          
Asn Gly Ile Ser Asn Pro Glu Lys Trp Cys Pro Lys Asp Phe Gly Val
        35                  40                  45              
Arg Tyr Asn Cys His Gln Glu Ile Arg Leu Lys Lys Asn Pro Ile Ala
    50                  55                  60                  
Glu Arg Lys Ser Lys Asn Leu Asp Val Thr Ser Arg Glu Asn Val Gly
65                  70                  75                  80  
Leu Asp Ile Asn Glu Asn Thr Lys Ser His Asp Gln Ser Glu Asn Glu
                85                  90                  95      
Asn Lys Lys His Glu Tyr Asp Asp Thr His Phe Phe Lys Asn Glu Ser
            100                 105                 110         
Glu Ser Asn Trp Val Cys Ser Arg Val Lys Glu Ile Glu Ser Cys Lys
        115                 120                 125             
Glu Asp Val Leu Asp Pro Glu Thr Ser Leu Pro Pro Gly Asn Phe Tyr
    130                 135                 140                 
Thr Ser Gln Ile Leu Trp Lys Lys Ile Glu Ala Leu Pro Pro Asp Lys
145                 150                 155                 160 
Leu Leu Asn Leu Ala Leu Glu His Cys Asp Ser Ser Glu Lys Glu Leu
                165                 170                 175     
Asn Phe Arg Val Leu Asp Ser Ser Tyr Gly Ile Thr Lys Ser Leu Glu
            180                 185                 190         
Asn Ile Tyr Ser Glu Pro Glu Gly Gln Glu Cys Gly Pro Ser Ile Asn
        195                 200                 205             
Pro Leu Pro Lys Pro Arg Arg Thr Phe Arg Tyr Leu Ser Glu Ser Gly
    210                 215                 220                 
Val Thr Pro Tyr Lys Glu Arg Asn Cys Asp Lys Lys Tyr Cys Glu Asn
225                 230                 235                 240 
Asn Ser Cys Ala Gln Ser Ser Leu Ala Ser Ser Gln Glu Pro Glu Pro
                245                 250                 255     
Lys Lys Tyr Gly Gly Lys Ile Arg Gly Arg Ser Lys Arg Lys Ser Phe
            260                 265                 270         
Glu Phe Glu Asp Ile Gln His Phe Arg Asn Arg Asn Ser Gln Thr Ile
        275                 280                 285             
Arg Glu Glu Leu Gly Arg Asn Ser Gly Ser Ala Leu Tyr Tyr Thr Gln
    290                 295                 300                 
Ser Glu Asp Asn Ile Tyr Glu Asp Ile Ile Tyr Pro Thr Lys Glu Asn
305                 310                 315                 320 
Pro Tyr Glu Asp Ile Pro Val Gln Pro Leu Pro Met Trp Arg Ser Pro
                325                 330                 335     
Ser Ala Trp Lys Leu Pro Pro Ala Lys Ser Ala Phe Lys Ala Pro Lys
            340                 345                 350         
Leu Pro Pro Lys Pro Gln Phe Leu His Arg Lys Thr Met Glu Val Lys
        355                 360                 365             
Asn Ser Gln Ala Tyr Leu Arg Ser Lys Leu Thr Lys Asp Thr Thr Leu
    370                 375                 380                 
Pro Val Thr Leu Thr Glu Trp Lys Leu Phe Arg Ala Gly Glu Val Ala
385                 390                 395                 400 
Asn Thr Lys Arg Lys Asn Leu Pro Arg Leu Val Leu Lys Ile Asp Asp
                405                 410                 415     
Ile Phe Glu Ser Lys Arg Gly Lys Lys Lys Val Lys Leu His Ser Tyr
            420                 425                 430         
Thr Gly Lys Glu Leu Pro Pro Thr Lys Gly Glu Thr Ser Gly Asn Glu
        435                 440                 445             
Ser Asp Ala Glu Tyr Leu Pro Lys Asn Arg His Lys Arg Leu Ala Gln
    450                 455                 460                 
Leu Gln Pro Ser Ser Lys Arg Asn Pro His Tyr Gln Thr Leu Glu Arg
465                 470                 475                 480 
Asp Leu Ile Glu Leu Gln Glu Gln Gln Leu Phe Glu Leu Phe Val Val
                485                 490                 495     
Val Ser Leu Gln Lys Lys Pro Ser Gly Ile Ser Tyr Ile Pro Gln Val
            500                 505                 510         
Ile Gln Gln Phe Pro Gly Lys Asp Asp His Gly Tyr Lys Gln Ser Lys
        515                 520                 525             
Asp Met Glu Glu Arg Leu Lys Val Ile Pro Lys Phe Cys Phe Pro Asp
    530                 535                 540                 
Ser Lys Asp Trp Met Pro Thr Ser Glu Leu Lys Ser Glu Thr Phe Ser
545                 550                 555                 560 
Phe Val Leu Thr Gly Glu Asp Gly Ser Arg Trp Phe Gly Tyr Cys Lys
                565                 570                 575     
Lys Leu Leu Pro Val Gly Lys Gly Lys Arg Leu Pro Glu Val Tyr Cys
            580                 585                 590         
Met Val Ser Arg Leu Gly Cys Phe Asn Leu Phe Ser Lys Ile Leu Asp
        595                 600                 605             
Glu Val Glu Lys Arg Arg Glu Met Ser Pro Ala Leu Val Tyr Pro Phe
    610                 615                 620                 
Met Arg Ser Val Met Glu Ala Pro Phe Pro Ala Pro Gly Arg Thr Ile
625                 630                 635                 640 
Thr Val Lys Ser Tyr Leu Pro Gly Ala Gly Asp Glu Ser Ile Glu Leu
                645                 650                 655     
Cys Arg Pro Leu Asp Ser Arg Leu Glu His Val Asp Phe Lys Cys Leu
            660                 665                 670         
Phe Lys Cys Leu Ser Val Cys His Leu Ile Arg Val Cys Ala Ser Leu
        675                 680                 685             
Leu Leu Glu Arg Arg Val Ile Phe Val Ala Asn Ser Leu Ser Thr Leu
    690                 695                 700                 
Ser Lys Cys Gly His Ala Val Val Ala Thr Leu Tyr Pro Phe Thr Trp
705                 710                 715                 720 
Gln His Thr Tyr Ile Pro Val Leu Pro Ala Ser Met Ile Asp Ile Val
                725                 730                 735     
Cys Ser Pro Thr Pro Phe Leu Ile Gly Ile Leu Ser Cys Ser Leu Pro
            740                 745                 750         
Gln Leu Gln Asp Leu Pro Ile Glu Glu Val Leu Ile Val Asp Leu Cys
        755                 760                 765             
Ala Asp Lys Phe Leu Gln Glu Val Ser Asp Glu Asp Glu Ile Leu Pro
    770                 775                 780                 
Pro Lys Leu Gln Ala Ala Leu Met Gln Ile Leu Glu Glu Arg Asn Glu
785                 790                 795                 800 
Ile Leu Thr Gln Glu Gln Asn Phe Ser Gln Asp Val Thr Leu Asn Ser
                805                 810                 815     
Leu Val Ser Glu Ala Phe Val Arg Phe Phe Val Glu Leu Val Gly His
            820                 825                 830         
Tyr Ser Leu Asn Met Thr Val Thr Glu Arg Gly Glu Arg Val Phe Gln
        835                 840                 845             
Arg Glu Pro Phe Arg Lys Ser His Thr Ser Arg Ser Val Arg His Phe
    850                 855                 860                 
Leu Asp Leu Phe Met Glu Thr Gln Met Phe Ala Gly Phe Ile Gln Asp
865                 870                 875                 880 
Arg Glu Leu Arg Lys Ser Gly Val Lys Gly Leu Phe Glu Ile Arg Ala
                885                 890                 895     
Ile Gln Tyr Leu Glu Thr Ile Pro Glu Ser Glu Pro Ser Gly Met Asn
            900                 905                 910         
Arg Ile Leu Arg Ser Leu Gly
        915                 


<210> 7560
<211> 179
<212> PRT
<213> Homo sapiens

<400> 7560
Met Asp Leu Pro Asp Ser Ala Ser Arg Val Phe Cys Gly Arg Ile Leu
 1               5                  10                  15      
Ser Met Val Asn Thr Asp Asp Val Asn Ala Ile Ile Leu Ala Gln Lys
            20                  25                  30          
Asn Met Leu Asp Arg Phe Glu Lys Thr Asn Glu Met Leu Leu Asn Phe
        35                  40                  45              
Asn Asn Leu Ser Ser Ala Arg Leu Gln Gln Met Ser Glu Arg Phe Leu
    50                  55                  60                  
His His Thr Arg Thr Leu Val Glu Met Lys Arg Asp Leu Asp Ser Ile
65                  70                  75                  80  
Phe Arg Arg Ile Arg Thr Leu Lys Gly Lys Leu Ala Arg Gln His Pro
                85                  90                  95      
Glu Ala Phe Ser His Ile Pro Glu Ala Ser Phe Leu Glu Glu Glu Asp
            100                 105                 110         
Glu Asp Pro Ile Pro Pro Ser Thr Thr Thr Thr Ile Ala Thr Ser Glu
        115                 120                 125             
Gln Ser Thr Gly Ser Cys Asp Thr Ser Pro Asp Thr Val Ser Pro Phe
    130                 135                 140                 
Leu Ser Pro Gly Phe Glu Asp Leu Ser His Val Gln Ala Gly Leu Pro
145                 150                 155                 160 
Ser His Gln Arg Arg Ser Arg Gln Met Thr Arg Asp Asp Ala Ile Ala
                165                 170                 175     
Ala Ala Cys
            


<210> 7561
<211> 176
<212> PRT
<213> Homo sapiens

<400> 7561
Met Asp Leu Pro Asp Ser Ala Ser Arg Val Phe Cys Gly Arg Ile Leu
 1               5                  10                  15      
Ser Met Val Asn Thr Asp Asp Val Asn Ala Ile Ile Leu Ala Gln Lys
            20                  25                  30          
Asn Met Leu Asp Arg Phe Glu Lys Thr Asn Glu Met Leu Leu Asn Phe
        35                  40                  45              
Asn Asn Leu Ser Ser Ala Arg Leu Gln Gln Met Ser Glu Arg Phe Leu
    50                  55                  60                  
His His Thr Arg Thr Leu Val Glu Met Lys Arg Asp Leu Asp Ser Ile
65                  70                  75                  80  
Phe Arg Arg Ile Arg Thr Leu Lys Gly Lys Leu Ala Arg Gln His Pro
                85                  90                  95      
Glu Ala Phe Ser His Ile Pro Glu Ala Ser Phe Leu Glu Glu Glu Asp
            100                 105                 110         
Glu Asp Pro Ile Pro Pro Ser Thr Thr Thr Thr Ile Ala Thr Ser Glu
        115                 120                 125             
Gln Ser Thr Gly Ser Cys Asp Thr Ser Pro Asp Thr Val Ser Pro Ser
    130                 135                 140                 
Leu Ser Pro Gly Phe Glu Asp Leu Ser His Val Gln Ala Gly Ser Pro
145                 150                 155                 160 
Ala Ile Asn Gly Arg Ser Gln Thr Asp Asp Glu Glu Met Thr Gly Glu
                165                 170                 175     


<210> 7562
<211> 274
<212> PRT
<213> Homo sapiens

<400> 7562
Arg Arg Arg Asn Ser Thr Arg Thr Asp Arg Pro Pro Ala Pro Ala Glu
 1               5                  10                  15      
Ala Glu Ala Val Ala Arg Ser Gly Pro Gly Pro Trp Ala Pro Arg Ala
            20                  25                  30          
Ala Arg Val Met Arg Thr Glu Ala Glu Ala Ala Gly Pro Pro Leu Glu
        35                  40                  45              
Pro Gly Asp Phe Val Gln Leu Pro Val Pro Val Ile Gln Gln Leu Tyr
    50                  55                  60                  
His Trp Asp Cys Gly Leu Ala Cys Ser Arg Met Val Leu Arg Tyr Leu
65                  70                  75                  80  
Gly Gln Leu Asp Asp Ser Glu Phe Glu Arg Ala Leu Gln Lys Leu Gln
                85                  90                  95      
Leu Thr Arg Ser Ile Trp Thr Ile Asp Leu Ala Tyr Leu Met His His
            100                 105                 110         
Phe Gly Val Arg His Arg Phe Cys Thr Gln Thr Leu Gly Val Asp Lys
        115                 120                 125             
Gly Tyr Lys Asn Gln Ser Phe Tyr Arg Lys His Phe Asp Thr Glu Glu
    130                 135                 140                 
Thr Arg Val Asn Gln Leu Phe Ala Gln Ala Lys Ala Cys Lys Val Leu
145                 150                 155                 160 
Val Glu Lys Cys Thr Val Ser Val Lys Asp Ile Gln Ala His Leu Ala
                165                 170                 175     
Gln Gly His Val Ala Ile Val Leu Val Asn Ser Gly Val Leu His Cys
            180                 185                 190         
Asp Leu Cys Ser Ser Pro Val Lys Tyr Cys Cys Phe Thr Pro Ser Gly
        195                 200                 205             
His His Cys Phe Cys Arg Thr Pro Asp Tyr Gln Gly His Phe Ile Val
    210                 215                 220                 
Leu Arg Gly Tyr Asn Arg Ala Thr Gly Cys Ile Phe Tyr Asn Asn Pro
225                 230                 235                 240 
Ala Tyr Ala Asp Arg Met Cys Ser Thr Ser Ile Ser Asn Phe Glu Glu
                245                 250                 255     
Ala Arg Thr Ser Tyr Gly Thr Asp Glu Asp Ile Leu Phe Val Tyr Leu
            260                 265                 270         
Asp Ser
        


<210> 7563
<211> 229
<212> PRT
<213> Homo sapiens

<400> 7563
Arg Asn Ser Thr Arg Thr Asp Arg Pro Pro Ala Pro Ala Glu Ala Glu
 1               5                  10                  15      
Ala Val Ala Arg Ser Gly Pro Gly Pro Trp Ala Pro Arg Ala Ala Arg
            20                  25                  30          
Val Met Arg Thr Glu Ala Glu Ala Ala Gly Pro Pro Leu Glu Pro Gly
        35                  40                  45              
Asp Phe Val Gln Leu Pro Val Pro Val Ile Gln Gln Leu Tyr His Trp
    50                  55                  60                  
Asp Cys Gly Leu Ala Cys Ser Arg Met Val Leu Arg Tyr Leu Gly Gln
65                  70                  75                  80  
Leu Asp Asp Ser Glu Phe Glu Arg Ala Leu Gln Lys Leu Gln Leu Thr
                85                  90                  95      
Arg Ser Ile Trp Thr Ile Asp Leu Ala Tyr Leu Met His His Phe Gly
            100                 105                 110         
Val Arg His Arg Phe Cys Thr Gln Thr Leu Gly Val Asp Lys Gly Tyr
        115                 120                 125             
Lys Asn Gln Ser Phe Tyr Arg Lys His Phe Asp Thr Glu Glu Thr Arg
    130                 135                 140                 
Val Asn Gln Leu Phe Ala Gln Ala Lys Ala Cys Lys Val Leu Val Glu
145                 150                 155                 160 
Lys Cys Gly His His Cys Phe Cys Arg Thr Pro Asp Tyr Gln Gly His
                165                 170                 175     
Phe Ile Val Leu Arg Gly Tyr Asn Arg Ala Thr Gly Cys Ile Phe Tyr
            180                 185                 190         
Asn Asn Pro Ala Tyr Ala Asp Arg Met Cys Ser Thr Ser Ile Ser Asn
        195                 200                 205             
Phe Glu Glu Ala Arg Thr Ser Tyr Gly Thr Asp Glu Asp Ile Leu Phe
    210                 215                 220                 
Val Tyr Leu Asp Ser
225                 


<210> 7564
<211> 296
<212> PRT
<213> Homo sapiens

<400> 7564
Met Thr Gly Pro Gly Gly Arg Arg Asn Asp Pro Trp Gly Arg Gln Arg
 1               5                  10                  15      
Ala Arg Glu Gly Ala His Thr Ser Lys His Pro Thr Pro Arg Thr Gly
            20                  25                  30          
Trp Thr Ala Arg Arg Arg Arg Gly Ala Trp Ala Leu Arg Pro Gly Thr
        35                  40                  45              
Ala Gly Gly Trp Ala Lys Gly Gln Asp Phe Pro Ser Gln Phe His Leu
    50                  55                  60                  
Leu Ile Pro Ala Pro Pro Gly Asp Phe Val Gln Leu Pro Val Pro Val
65                  70                  75                  80  
Ile Gln Gln Leu Tyr His Trp Asp Cys Gly Leu Ala Cys Ser Arg Met
                85                  90                  95      
Val Leu Arg Tyr Leu Gly Gln Leu Asp Asp Ser Glu Phe Glu Arg Ala
            100                 105                 110         
Leu Gln Lys Leu Gln Leu Thr Arg Ser Ile Trp Thr Ile Asp Leu Ala
        115                 120                 125             
Tyr Leu Met His His Phe Gly Val Arg His Arg Phe Cys Thr Gln Thr
    130                 135                 140                 
Leu Gly Val Asp Lys Gly Tyr Lys Asn Gln Ser Phe Tyr Arg Lys His
145                 150                 155                 160 
Phe Asp Thr Glu Glu Thr Arg Val Asn Gln Leu Phe Ala Gln Ala Lys
                165                 170                 175     
Ala Cys Lys Val Leu Val Glu Lys Cys Thr Val Ser Val Lys Asp Ile
            180                 185                 190         
Gln Ala His Leu Ala Gln Gly His Val Ala Ile Val Leu Val Asn Ser
        195                 200                 205             
Gly Val Leu His Cys Asp Leu Cys Ser Ser Pro Val Lys Tyr Cys Cys
    210                 215                 220                 
Phe Thr Pro Ser Gly His His Cys Phe Cys Arg Thr Pro Asp Tyr Gln
225                 230                 235                 240 
Gly His Phe Ile Val Leu Arg Gly Tyr Asn Arg Ala Thr Gly Cys Ile
                245                 250                 255     
Phe Tyr Asn Asn Pro Ala Tyr Ala Asp Pro Gly Met Cys Ser Thr Ser
            260                 265                 270         
Ile Ser Asn Phe Glu Glu Ala Arg Thr Ser Tyr Gly Thr Asp Glu Asp
        275                 280                 285             
Ile Leu Phe Val Tyr Leu Asp Ser
    290                 295     


<210> 7565
<211> 239
<212> PRT
<213> Homo sapiens

<400> 7565
Met Arg Thr Glu Ala Glu Ala Ala Gly Pro Pro Leu Glu Pro Gly Asp
 1               5                  10                  15      
Phe Val Gln Leu Pro Val Pro Val Ile Gln Gln Leu Tyr His Trp Asp
            20                  25                  30          
Cys Gly Leu Ala Cys Ser Arg Met Val Leu Arg Tyr Leu Gly Gln Leu
        35                  40                  45              
Asp Asp Ser Glu Phe Glu Arg Ala Leu Gln Lys Leu Gln Leu Thr Arg
    50                  55                  60                  
Ser Ile Trp Thr Ile Asp Leu Ala Tyr Leu Met His His Phe Gly Val
65                  70                  75                  80  
Arg His Arg Phe Cys Thr Gln Thr Leu Gly Val Asp Lys Gly Tyr Lys
                85                  90                  95      
Asn Gln Ser Phe Tyr Arg Lys His Phe Asp Thr Glu Glu Thr Arg Val
            100                 105                 110         
Asn Gln Leu Phe Ala Gln Ala Lys Ala Cys Lys Val Leu Val Glu Lys
        115                 120                 125             
Cys Thr Val Ser Val Lys Asp Ile Gln Ala His Leu Ala Gln Gly His
    130                 135                 140                 
Val Ala Ile Val Leu Val Asn Ser Gly Val Leu His Cys Asp Leu Cys
145                 150                 155                 160 
Ser Ser Pro Val Lys Tyr Cys Cys Phe Thr Pro Ser Gly His His Cys
                165                 170                 175     
Phe Cys Arg Thr Pro Asp Tyr Gln Gly His Phe Ile Val Leu Arg Gly
            180                 185                 190         
Tyr Asn Arg Ala Thr Gly Cys Ile Phe Tyr Asn Asn Pro Ala Tyr Ala
        195                 200                 205             
Asp Arg Met Cys Ser Thr Ser Ile Ser Asn Phe Glu Glu Ala Arg Thr
    210                 215                 220                 
Ser Tyr Gly Thr Asp Glu Asp Ile Leu Phe Val Tyr Leu Asp Ser
225                 230                 235                 


<210> 7566
<211> 745
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 146, 206, 517, 676
<223> Xaa = Any Amino Acid

<400> 7566
Met Gly Lys Glu Tyr Gly Leu Trp Ala Pro Gly Ala Ile His Val Gly
 1               5                  10                  15      
Cys Arg Cys Cys Gly Ser Ile Asn Gln Ser Phe Asp Gly Arg Ala Gln
            20                  25                  30          
Ser Val Val Glu Glu Ala Gly Trp Asp Arg Ala Leu Ile Gln Leu Gln
        35                  40                  45              
Val Arg Ala Leu Leu Ser Ser Thr Gly Ser Gln Ala Val Ala Met Asp
    50                  55                  60                  
Leu Gly Asn Arg Lys Leu Glu Ile Ser Ser Gly Lys Leu Ala Arg Phe
65                  70                  75                  80  
Ala Asn Gly Ser Ala Val Ile Gln Ser Gly Asp Thr Ala Val Met Ala
                85                  90                  95      
Thr Ala Val Ser Lys Thr Lys Pro Ser Pro Ser Gln Phe Met Pro Leu
            100                 105                 110         
Val Val Asp Tyr Gly Gln Lys Ala Ala Ala Val Gly Arg Ile Pro Thr
        115                 120                 125             
Asn Pro Leu Arg Arg Glu Ile Ser Thr Ser Asp Lys Glu Ile Leu Thr
    130                 135                 140                 
Arg Xaa Ile Val Asp Cys Ser Val Arg Pro Ile Phe Pro Ala Gly Tyr
145                 150                 155                 160 
Phe Cys Asp Ile Gln Val Leu Cys Asn Leu Leu Ala Val Asp Gly Ile
                165                 170                 175     
Asn Glu Leu Asp Val Leu Ala Ile Asn Gly Asn Ser Val Ala Leu Ser
            180                 185                 190         
Leu Ser Asp Ile Leu Trp Asn Gly Pro Val Gly Thr Val Xaa Ile Gly
        195                 200                 205             
Met Thr Asp Gly Glu Cys Val Val Asn Pro Thr Arg Lys Glu Met Ser
    210                 215                 220                 
Ser Ser Thr Leu Asn Val Val Val Ala Gly Ala Pro Lys Ser Gln Thr
225                 230                 235                 240 
Val Met Leu Glu Ala Ser Ala Glu Asn Ile Leu Gln Gln Asp Phe Cys
                245                 250                 255     
His Ala Ile Lys Val Gly Val Lys Tyr Thr Gln Gln Ile Ile Gln Gly
            260                 265                 270         
Ile Gln Gln Leu Val Lys Glu Ile Gly Val Thr Lys Arg Thr Pro Gln
        275                 280                 285             
Lys Leu Phe Thr Pro Ser Gln Glu Ile Val Lys His Ala His Lys Leu
    290                 295                 300                 
Thr Met Glu Arg Leu Tyr Ala Val Phe Thr Asp Tyr Glu His Asp Lys
305                 310                 315                 320 
Ile Ser Arg Asp Glu Ala Val Asn Lys Ile Arg Leu Asp Thr Glu Glu
                325                 330                 335     
Gln Leu Lys Glu Ile Phe Pro Glu Val Asp Leu Tyr Glu Ile Ile Glu
            340                 345                 350         
Ser Phe Asn Thr Val Ala Lys Lys Val Phe Arg Ser Ile Ile Leu Asn
        355                 360                 365             
Glu Tyr Lys Arg Cys Asp Gly Arg Asp Leu Thr Leu Leu Arg Asn Ile
    370                 375                 380                 
Ser Cys Glu Val Asp Met Phe Lys Thr Leu His Gly Ser Glu Leu Phe
385                 390                 395                 400 
Gln Arg Gly Gln Thr Gln Leu Leu Cys Ala Val Thr Phe Asp Ser Leu
                405                 410                 415     
Glu Ser Ser Ile Lys Leu Asp Arg Val Ile Thr Thr Ile Asn Gly Ile
            420                 425                 430         
Lys Asp Lys Asn Phe Met Leu His Tyr Glu Phe Pro Pro Tyr Ala Thr
        435                 440                 445             
Asn Glu Ile Val Lys Val Thr Gly Ile Asn Arg Arg Glu Leu Gly Pro
    450                 455                 460                 
Asp Ala Leu Ala Glu Lys Ala Leu Tyr Pro Val Ile Pro Lys Asp Phe
465                 470                 475                 480 
Pro Phe Ala Ile Arg Val Thr Ser Glu Val Leu Glu Ser Asn Gly Ser
                485                 490                 495     
Ser Ser Met Ala Ser Ala Cys Gly Gly Ser Leu Ala Leu Met Asp Ser
            500                 505                 510         
Gly Leu Pro Ile Xaa Ser Ala Val Thr Gly Val Ala Met Gly Leu Ala
        515                 520                 525             
Thr Lys Thr Asp Leu Glu Lys Gly Glu Ile Glu Asp Tyr His Leu Leu
    530                 535                 540                 
Thr Asp Ile Leu Gly Ile Glu Ala Tyr Asn Gly Asp Met Asp Phe Lys
545                 550                 555                 560 
Ile Ala Gly Thr Asn Lys Gly Ile Thr Ala Leu Gln Ala Asp Ile Lys
                565                 570                 575     
Leu Pro Gly Ile Thr Met Lys Ile Val Met Glu Ala Ile Gln Gln Ala
            580                 585                 590         
Ser Ala Glu Thr Val Val Thr Ile Ser Gln Val Asp Glu Glu Thr Phe
        595                 600                 605             
Ser Ile Phe Ala Pro Thr Pro Gly Ala Met His Glu Ala Arg Asp Phe
    610                 615                 620                 
Ile Ala Glu Ile Arg Lys Asp Asp Gln Glu Gln Gln Leu Glu Phe Gly
625                 630                 635                 640 
Ala Val Cys Thr Ala Thr Ile Thr Glu Ser Arg Asp Thr Gly Val Met
                645                 650                 655     
Val Lys Leu Tyr Pro Asn Met Ile Leu Val Leu Leu Tyr Asn Thr Gln
            660                 665                 670         
Leu Asp Gln Xaa Asn Ile Lys His Pro Thr Ala Leu Gly Leu Glu Val
        675                 680                 685             
Gly Gln Glu Ile Gln Val Lys Tyr Phe Gly Cys Asp Pro Ala Asp Gly
    690                 695                 700                 
Arg Met Arg Leu Ser His Lys Val Leu Gln Ser Ser Ala Thr Thr Val
705                 710                 715                 720 
Val Arg Thr Leu Asn Asp Arg Ser Ser Ile Val Leu Gly Glu Pro Ile
                725                 730                 735     
Ser Gln Ser Ser Ser Asn Asn Ser Gln
            740                 745 


<210> 7567
<211> 763
<212> PRT
<213> Homo sapiens

<400> 7567
Arg Tyr Pro Gly Ala Arg Cys Arg Asn Leu Pro Ser Ser Trp Pro Ala
 1               5                  10                  15      
Thr Val Arg Pro Asp Pro His Pro Asp Gln Ser Ser Cys Pro Gly Cys
            20                  25                  30          
Cys Asp Ala Gly Ser Ala Gly Cys Arg Arg Ala Ala Gly Ala Pro Glu
        35                  40                  45              
Gly Tyr Arg Val His Glu Arg Leu Ala Leu Pro Ala Leu Pro Arg Pro
    50                  55                  60                  
Leu Ala Arg Arg Pro Ala Arg Arg Leu Ala Arg Gln Pro Leu Gly Ala
65                  70                  75                  80  
Arg Arg Arg Arg Arg Arg Trp Arg Arg Arg Ser Gln Glu Val Pro Ser
                85                  90                  95      
Ala Ser Gln Val Arg Ala Ser Leu Pro Glu Pro Arg Asn Ser Ala Ala
            100                 105                 110         
Ala Met Ala Ser Asn Met Asp Arg Glu Met Ile Leu Ala Asp Phe Gln
        115                 120                 125             
Ala Cys Thr Gly Ile Glu Asn Ile Asp Glu Ala Ile Thr Leu Leu Glu
    130                 135                 140                 
Gln Asn Asn Trp Asp Leu Val Ala Ala Ile Asn Gly Val Ile Pro Gln
145                 150                 155                 160 
Glu Asn Gly Ile Leu Gln Ser Glu Tyr Gly Gly Glu Thr Ile Pro Gly
                165                 170                 175     
Pro Ala Phe Asn Pro Ala Ser His Pro Ala Ser Ala Pro Thr Ser Ser
            180                 185                 190         
Ser Ser Ser Ala Phe Arg Pro Val Met Pro Ser Arg Gln Ile Val Glu
        195                 200                 205             
Arg Gln Pro Arg Met Leu Asp Phe Arg Val Glu Tyr Arg Asp Arg Asn
    210                 215                 220                 
Val Asp Val Val Leu Glu Asp Thr Cys Thr Val Gly Glu Ile Lys Gln
225                 230                 235                 240 
Ile Leu Glu Asn Glu Leu Gln Ile Pro Val Ser Lys Met Leu Leu Lys
                245                 250                 255     
Gly Trp Lys Thr Gly Asp Val Glu Asp Ser Thr Val Leu Lys Ser Leu
            260                 265                 270         
His Leu Pro Lys Asn Asn Ser Leu Tyr Val Leu Thr Pro Asp Leu Pro
        275                 280                 285             
Pro Pro Ser Ser Ser Ser His Ala Gly Ala Leu Gln Glu Ser Leu Asn
    290                 295                 300                 
Gln Asn Phe Met Leu Ile Ile Thr His Arg Glu Val Gln Arg Glu Tyr
305                 310                 315                 320 
Asn Leu Asn Phe Ser Gly Ser Ser Thr Ile Gln Glu Val Lys Arg Asn
                325                 330                 335     
Val Tyr Asp Leu Thr Ser Ile Pro Val Arg His Gln Leu Trp Glu Gly
            340                 345                 350         
Trp Pro Thr Ser Ala Thr Asp Asp Ser Met Cys Leu Ala Glu Ser Gly
        355                 360                 365             
Leu Ser Tyr Pro Cys His Arg Leu Thr Val Gly Arg Arg Ser Ser Pro
    370                 375                 380                 
Ala Gln Thr Arg Glu Gln Ser Glu Glu Gln Ile Thr Asp Val His Met
385                 390                 395                 400 
Val Ser Asp Ser Asp Gly Asp Asp Phe Glu Asp Ala Thr Glu Phe Gly
                405                 410                 415     
Val Asp Asp Gly Glu Val Phe Gly Met Ala Ser Ser Ala Leu Arg Lys
            420                 425                 430         
Ser Pro Met Met Pro Glu Asn Ala Glu Asn Glu Gly Asp Ala Leu Leu
        435                 440                 445             
Gln Phe Thr Ala Glu Phe Ser Ser Arg Tyr Gly Asp Cys His Pro Val
    450                 455                 460                 
Phe Phe Ile Gly Ser Leu Glu Ala Ala Phe Gln Glu Ala Phe Tyr Val
465                 470                 475                 480 
Lys Ala Arg Asp Arg Lys Leu Leu Ala Ile Tyr Leu His His Asp Glu
                485                 490                 495     
Ser Val Leu Thr Asn Val Phe Cys Ser Gln Met Leu Cys Ala Glu Ser
            500                 505                 510         
Ile Val Ser Tyr Leu Ser Gln Asn Phe Ile Thr Trp Ala Trp Asp Leu
        515                 520                 525             
Thr Lys Asp Ser Asn Arg Ala Arg Phe Leu Thr Met Cys Asn Arg His
    530                 535                 540                 
Phe Gly Ser Val Val Ala Gln Thr Ile Arg Thr Gln Lys Thr Asp Gln
545                 550                 555                 560 
Phe Pro Leu Phe Leu Ile Ile Met Gly Lys Arg Ser Ser Asn Glu Val
                565                 570                 575     
Leu Asn Val Ile Gln Gly Asn Thr Thr Val Asp Glu Leu Met Met Arg
            580                 585                 590         
Leu Met Ala Ala Met Glu Ile Phe Thr Ala Gln Gln Gln Glu Asp Ile
        595                 600                 605             
Lys Asp Glu Asp Glu Arg Glu Ala Arg Glu Asn Val Lys Arg Glu Gln
    610                 615                 620                 
Asp Glu Ala Tyr Arg Leu Ser Leu Glu Ala Asp Arg Ala Lys Arg Glu
625                 630                 635                 640 
Ala His Glu Arg Glu Met Ala Glu Gln Phe Arg Leu Glu Gln Ile Arg
                645                 650                 655     
Lys Glu Gln Glu Glu Glu Arg Glu Ala Ile Arg Leu Ser Leu Glu Gln
            660                 665                 670         
Ala Leu Pro Pro Glu Pro Lys Glu Glu Asn Ala Glu Pro Val Ser Lys
        675                 680                 685             
Leu Arg Ile Arg Thr Pro Ser Gly Glu Phe Leu Glu Arg Arg Phe Leu
    690                 695                 700                 
Ala Ser Asn Lys Leu Gln Ile Val Phe Asp Phe Val Ala Ser Lys Gly
705                 710                 715                 720 
Phe Pro Trp Asp Glu Tyr Lys Leu Leu Ser Thr Phe Pro Arg Arg Asp
                725                 730                 735     
Val Thr Gln Leu Asp Pro Asn Lys Ser Leu Leu Glu Val Lys Leu Phe
            740                 745                 750         
Pro Gln Glu Thr Leu Phe Leu Glu Ala Lys Glu
        755                 760             


<210> 7568
<211> 1578
<212> PRT
<213> Homo sapiens

<400> 7568
Met Glu Glu Leu Glu Thr Ser Leu Phe Gln Thr Arg Lys Ala His Arg
 1               5                  10                  15      
Ile Glu Gln Met Val Ala Arg Trp Leu Arg Arg Ser Arg Asp Ser Ser
            20                  25                  30          
Ala Arg Ala Lys Val Ala Ala Ala Asp Gly Pro Ala Arg Asn Pro Thr
        35                  40                  45              
Gln Thr Leu Ile Pro Val Arg His Thr Val Lys Ile Asp Lys Asp Thr
    50                  55                  60                  
Leu Leu Gln Asp Tyr Gly Phe His Ile Ser Glu Ser Leu Pro Leu Thr
65                  70                  75                  80  
Val Val Ala Val Thr Ala Gly Gly Ser Ala His Gly Lys Leu Phe Pro
                85                  90                  95      
Gly Asp Gln Ile Leu Gln Met Asn Asn Glu Pro Ala Glu Asp Leu Ser
            100                 105                 110         
Trp Glu Arg Ala Val Asp Ile Leu Arg Glu Ala Glu Asp Ser Leu Ser
        115                 120                 125             
Ile Thr Val Val Arg Cys Thr Ser Gly Val Pro Lys Ser Ser Phe Leu
    130                 135                 140                 
Thr Glu Glu Lys Arg Ala Arg Leu Lys Thr Asn Pro Val Lys Val His
145                 150                 155                 160 
Phe Ala Glu Glu Val Leu Ile Ser Gly His Ser Gln Gly Asn Ser Leu
                165                 170                 175     
Leu Cys Met Pro Asn Val Leu Lys Leu Tyr Leu Glu Asn Gly Gln Thr
            180                 185                 190         
Lys Ala Phe Lys Phe Glu Ala Asn Thr Thr Val Lys Asp Ile Ile Leu
        195                 200                 205             
Thr Val Lys Glu Lys Leu Ser Ile Arg Ser Ile Glu Tyr Phe Ala Leu
    210                 215                 220                 
Ala Leu Glu Glu Gln Tyr Ser Ile Ser Arg Leu His Leu Leu His Glu
225                 230                 235                 240 
Glu Glu Leu Ile Gln Gln Val Val Glu Arg Glu Glu Ser His Asp Tyr
                245                 250                 255     
Arg Cys Leu Phe Arg Val Cys Phe Val Pro Lys Asp Pro Leu Asp Leu
            260                 265                 270         
Leu Lys Glu Asp Pro Val Ala Phe Glu Tyr Leu Tyr Leu Gln Ser Cys
        275                 280                 285             
Ser Asp Val Leu Gln Glu Arg Phe Ala Val Glu Met Lys Cys Ser Ser
    290                 295                 300                 
Ala Leu Arg Leu Ala Ala Leu His Ile Gln Glu Arg Ile Tyr Ala Cys
305                 310                 315                 320 
Ala Gln Pro Gln Lys Ile Ser Leu Lys Tyr Ile Glu Lys Asp Trp Gly
                325                 330                 335     
Ile Glu Asn Phe Ile Ser Pro Thr Leu Leu Arg Asn Met Lys Gly Lys
            340                 345                 350         
Asp Ile Lys Lys Ala Ile Ser Phe His Met Lys Arg Asn Gln Asn Leu
        355                 360                 365             
Leu Glu Pro Arg Gln Lys Gln Leu Ile Ser Ala Ala Gln Leu Arg Leu
    370                 375                 380                 
Asn Tyr Leu Gln Ile Leu Gly Glu Leu Lys Thr Tyr Gly Gly Arg Ile
385                 390                 395                 400 
Phe Asn Ala Thr Leu Met Leu Gln Asp Arg Glu Ser Tyr Ile Ala Leu
                405                 410                 415     
Leu Val Gly Ala Lys Tyr Gly Ile Ser Gln Val Ile Asn Ser Lys Leu
            420                 425                 430         
Asn Ile Met Ser Thr Leu Ala Glu Phe Ala Asn Ile Ser Arg Val Glu
        435                 440                 445             
Leu Thr Glu Glu Ser Glu Lys Val Ser Val Val Lys Val Tyr Leu Gln
    450                 455                 460                 
Asp Val Lys Val Leu Thr Leu Leu Leu Glu Ser Asn Ser Ala Lys Asp
465                 470                 475                 480 
Leu Ala Cys Leu Ile Ala Gly Tyr Tyr Arg Leu Leu Val Asp Pro Val
                485                 490                 495     
Thr Ser Ile Phe Leu Trp Pro Gly Asn Lys Gln Gln Ala His Arg Val
            500                 505                 510         
Ser Ala Glu Glu Gly Tyr Glu Ser Arg Ala Cys Ser Asp Ser Glu Glu
        515                 520                 525             
Ser Ser Glu Val Asp Cys Val Leu Glu Pro Leu Ser Asp Arg Arg Leu
    530                 535                 540                 
Val Lys Leu Ala Pro Cys Arg Ser Leu Ile Lys Glu Glu Gln Pro Pro
545                 550                 555                 560 
Gly Asn Ser Pro Thr Pro Glu Val Ala Arg Arg Gly Pro Ser Thr Cys
                565                 570                 575     
Gly Ala Ser Ser Thr Thr Asp Ser Ala Glu Ser Glu Ala Ser Asp Ser
            580                 585                 590         
Ala Asn Thr Glu Ser Arg Gly Tyr Arg Thr Ser Gly Ser Ser Glu Ser
        595                 600                 605             
Met Asp Ala Leu Glu Glu Asp Asp Leu Asp Thr Cys Ser Ser Ser Arg
    610                 615                 620                 
Ser Thr Phe Phe His Phe Gly Ser Pro Gly Leu Ala Glu Ser Ile Asp
625                 630                 635                 640 
Ser Asp Ser Gln Glu Glu Arg Ser Gly Ile Glu Thr Ser Gly Phe Leu
                645                 650                 655     
Cys Leu Leu Asp Leu Ala Gln Arg Ala Asn Pro Gln Cys Gln Lys Thr
            660                 665                 670         
Glu Phe Ser Glu Ser Ala Ala Leu Glu Thr Phe Gly Trp Ala Pro Glu
        675                 680                 685             
Leu Ser Thr Val Arg Leu Asp Pro Arg Leu Tyr Glu Gly Ser His Ala
    690                 695                 700                 
Asp Tyr Tyr Ser Leu Cys Ser Ser Val Ser Pro Ala Ser Tyr Leu Ser
705                 710                 715                 720 
Asp Ser Ser Glu Ser Thr Ala Ser Arg Gln Gly Gly Ala Pro Pro Ala
                725                 730                 735     
Trp Gly Gln Gln Gly Trp Thr Glu Ala Gln Pro Ser Ser Met Leu Glu
            740                 745                 750         
Pro Leu Ala Leu His Pro Pro Leu Ala Phe Glu Asp Gly Ser Ser Asp
        755                 760                 765             
Glu Glu Tyr Tyr Asp Ala Ala Asp Lys Leu Thr Pro Pro Gly Pro Pro
    770                 775                 780                 
Ser Gly Pro Arg Asp Val Ser Thr Ala Glu Pro Ser Ala Thr Ser Leu
785                 790                 795                 800 
Gln Asn Lys Ala Ser Thr Ser Ser Pro Glu Asn Ser Leu Pro Cys Gly
                805                 810                 815     
Pro Asp Gly Arg Gln Pro Ser Arg Arg Gly Gly Val Lys Lys Tyr Ala
            820                 825                 830         
Lys Thr Leu Arg Lys Arg Arg Ser Phe Leu Gln Thr Asp Tyr Thr Ser
        835                 840                 845             
Gln Val Ser Phe Pro Leu Val Pro Ser Ala Ser Leu Glu Ser Val Asp
    850                 855                 860                 
Asp Val Cys Tyr Tyr Asp Arg Glu Pro Tyr Leu Ala Leu Gly Ala Pro
865                 870                 875                 880 
Ser Pro Thr Val Ser Ser Leu Gln Asp Met Gln Gly Glu Pro Gly Leu
                885                 890                 895     
Leu Glu Thr Lys Ala Leu Gly Leu Leu Ala Pro Leu Arg Glu Thr Lys
            900                 905                 910         
Ser Thr Asn Pro Ala Ser Arg Val Met Glu Met Glu Pro Glu Thr Met
        915                 920                 925             
Glu Thr Lys Ser Val Ile Asp Ser Arg Val Ser Ser Ile Ser Ala Ile
    930                 935                 940                 
Arg Phe Arg Ile Asp Pro Asn Asn Lys Glu Asn Ser Gly Val Val Pro
945                 950                 955                 960 
Ala Ala Ser Ser Ser Ala Ser Thr Pro His Cys Ser Asn Pro Gly Ser
                965                 970                 975     
Ser Gly Pro Asp Thr Ala Gln Ala Arg Pro Ser Gln Ile Leu Pro Leu
            980                 985                 990         
Ser Gln Asp Leu Asp Gly Ile Ala Pro Lys Glu Pro Thr Ile Glu His
        995                 1000                1005            
Gly Asp Ser Ser Phe Ser Leu Ser Ser Gly Asp Pro Asn Pro Asp Arg
    1010                1015                1020                
Ala Cys Leu Ala Ser Asn Pro Gly Leu Asn Asn Val Ser Gln Gly Asp
1025                1030                1035                1040
Thr Leu Glu Leu Gln Leu Glu Pro His Val Gln Leu Glu Met Gly Leu
                1045                1050                1055    
Glu Ser Phe Cys Thr Asn His Ile Gln Glu Thr Ala Pro Lys Tyr Thr
            1060                1065                1070        
Glu Pro Leu Leu Ser Pro Arg Asp Glu Pro Arg Ser Asp Glu Cys Gly
        1075                1080                1085            
Ile Asn Pro Gly Glu Lys Ile Ala Ser Ile Pro Thr Lys Glu Glu Pro
    1090                1095                1100                
Gln Gly Gln Leu Ser Leu Glu Arg Asp Arg Glu Val Thr Asn Lys Asn
1105                1110                1115                1120
Gly Thr Asn Val Phe Gln Glu Glu Ser Arg Lys Asp Ser Gly Asp Ser
                1125                1130                1135    
Pro Gly Asp Val Ser Asn Asn Val Ser Gln Thr Leu Asp Ile Ser Ser
            1140                1145                1150        
Pro Ala Gly Lys Ile Val Thr Ser Leu Ser Leu Asp Ala Pro Val Thr
        1155                1160                1165            
Gly Thr Glu Gln Ile Pro Pro His Pro Pro Arg Asp Pro Gln Gly Gln
    1170                1175                1180                
Ser Arg Glu Pro Pro Gly Gln Gly Cys Gln Ala Gln Glu Gln Lys Leu
1185                1190                1195                1200
Phe Val Glu Leu Asp Leu Asp Pro Asp Phe Phe Leu Gly Lys Gln Thr
                1205                1210                1215    
Val Ser Pro Ala Val Pro Pro Glu Gly Ile Lys Ala Glu Ala Pro Asn
            1220                1225                1230        
His Val Thr Gly Gln Asp Ile Ala Pro Arg Asp Ser Pro Glu Trp Val
        1235                1240                1245            
Cys Phe Asn Pro Glu Pro Ser Leu Pro Glu Pro Leu Pro Cys Pro Gln
    1250                1255                1260                
Glu Asp Pro His Leu Glu Thr Ser Asn His Cys Leu Leu Leu Glu Gly
1265                1270                1275                1280
Lys Ser Asp Ser Ser Ser Ile Cys Leu Ser Ala Glu Lys Ser Phe Leu
                1285                1290                1295    
Cys Phe Ala Pro Glu Ser His Pro Glu Val Ser Ala Ser Leu Arg Val
            1300                1305                1310        
Ala Thr Ser Leu Gly Phe Ala Gly Met Asn Glu Met Val Ala Pro Arg
        1315                1320                1325            
Ile Gly Met Asp Gln Cys Ser Cys Gln Phe Ser Tyr Ala Thr Cys Phe
    1330                1335                1340                
Arg Gly Pro Gln Pro Glu Thr Glu Glu Glu Asp Arg Asp Leu Glu Ala
1345                1350                1355                1360
His Pro Met Ala Pro Leu Thr Ser Pro Pro Ser Ala Gly Ser Pro Val
                1365                1370                1375    
Val Leu Pro Trp Arg Pro Ala Arg Ala His Ser Cys Thr Thr Ala Pro
            1380                1385                1390        
Leu Ser Arg Lys Ser His Ile Trp Pro Glu Tyr Cys Ser Arg Ala Leu
        1395                1400                1405            
Arg Gln Leu Lys Ala Thr Pro Ala Ser Thr Pro Glu Gly Phe Ile Gln
    1410                1415                1420                
Leu Met Glu Ser Leu Leu Glu Leu Gln Asp Ile Leu Glu Thr Ser Trp
1425                1430                1435                1440
Gly Val Gly Asn Lys His Pro Pro Glu Lys Cys Thr Trp His Phe Thr
                1445                1450                1455    
Glu Ser Arg Ser Arg Leu Cys Met Gly Ser Gln Lys Leu Leu Ser Ser
            1460                1465                1470        
Cys Arg His Val Ile Arg Met Asp Gln Ser Pro Glu Glu Met Gln Gly
        1475                1480                1485            
Ala Val Arg Asp Thr Phe Gln His Leu Val Gln Leu Ala Gly Leu Cys
    1490                1495                1500                
Phe Gln Phe Thr Asp Cys Ser Arg Cys Ser Ala Arg His Arg Glu Ala
1505                1510                1515                1520
Ala Gly Asn Leu Arg Asp Val Val Tyr Thr Tyr His Gln Phe Ile Glu
                1525                1530                1535    
Ala Ala Lys Ser Thr Cys Glu Arg Gly Tyr His Asp Leu Ser Val Lys
            1540                1545                1550        
Leu Leu Ala Arg Gln Cys Thr Ala Leu Thr Ala Ala Val Phe Cys Leu
        1555                1560                1565            
Thr Gln Lys Phe Arg Ala Ser Thr Ala Leu
    1570                1575            


<210> 7569
<211> 453
<212> PRT
<213> Homo sapiens

<400> 7569
Met Trp Ser Pro Glu Arg Glu Ala Glu Ala Pro Ala Gly Gly Asp Pro
 1               5                  10                  15      
Ala Gly Leu Leu Pro Pro Glu Trp Glu Glu Asp Glu Glu Arg Met Ser
            20                  25                  30          
Phe Leu Phe Ser Ala Phe Lys Arg Ser Arg Glu Val Asn Ser Thr Asp
        35                  40                  45              
Trp Asp Ser Lys Met Gly Phe Trp Ala Pro Leu Val Leu Ser His Ser
    50                  55                  60                  
Arg Arg Gln Gly Val Val Arg Leu Arg Leu Arg Asp Leu Gln Glu Ala
65                  70                  75                  80  
Phe Gln Arg Lys Gly Ser Val Pro Leu Gly Leu Ala Thr Val Leu Gln
                85                  90                  95      
Asp Leu Leu Arg Arg Gly Glu Leu Gln Arg Glu Ser Asp Phe Met Ala
            100                 105                 110         
Ser Val Asp Ser Ser Trp Ile Ser Trp Gly Val Gly Val Phe Leu Leu
        115                 120                 125             
Lys Pro Leu Lys Trp Thr Leu Ser Asn Met Leu Gly Asp Asn Lys Val
    130                 135                 140                 
Pro Ala Glu Glu Val Leu Val Ala Val Glu Leu Leu Lys Glu Lys Ala
145                 150                 155                 160 
Glu Glu Val Tyr Arg Leu Tyr Gln Asn Ser Pro Leu Ser Ser His Pro
                165                 170                 175     
Val Val Ala Leu Ser Glu Leu Ser Thr Leu Cys Ala Asn Ser Cys Pro
            180                 185                 190         
Asp Glu Arg Thr Phe Tyr Leu Val Leu Leu Gln Leu Gln Lys Glu Lys
        195                 200                 205             
Arg Val Thr Val Leu Glu Gln Asn Gly Glu Lys Ile Val Lys Phe Ala
    210                 215                 220                 
Arg Gly Pro Arg Ala Lys Val Ser Pro Val Asn Asp Val Asp Val Gly
225                 230                 235                 240 
Val Tyr Gln Leu Met Gln Ser Glu Gln Leu Leu Ser Arg Lys Val Glu
                245                 250                 255     
Ser Leu Ser Gln Glu Ala Glu Arg Cys Lys Glu Glu Ala Arg Arg Ala
            260                 265                 270         
Cys Arg Ala Gly Lys Lys Gln Leu Ala Leu Arg Ser Leu Lys Ala Lys
        275                 280                 285             
Gln Arg Thr Glu Lys Arg Ile Glu Ala Leu His Ala Lys Leu Asp Thr
    290                 295                 300                 
Val Gln Gly Ile Leu Asp Arg Ile Tyr Ala Ser Gln Thr Asp Gln Met
305                 310                 315                 320 
Val Phe Asn Ala Tyr Gln Ala Gly Val Gly Ala Leu Lys Leu Ser Met
                325                 330                 335     
Lys Asp Val Thr Val Glu Lys Ala Glu Ser Leu Val Asp Gln Ile Gln
            340                 345                 350         
Glu Leu Cys Asp Thr Gln Asp Glu Val Ser Gln Thr Leu Ala Gly Gly
        355                 360                 365             
Val Thr Asn Gly Leu Asp Phe Asp Ser Glu Glu Leu Glu Lys Glu Leu
    370                 375                 380                 
Asp Ile Leu Leu Gln Asp Thr Thr Lys Glu Pro Leu Asp Leu Pro Asp
385                 390                 395                 400 
Asn Pro Arg Asn Arg His Phe Thr Asn Ser Val Pro Asn Pro Arg Ile
                405                 410                 415     
Ser Asp Ala Glu Leu Glu Ala Glu Leu Glu Lys Leu Ser Leu Ser Glu
            420                 425                 430         
Gly Gly Leu Val Pro Ser Ser Lys Ser Pro Lys Arg Gln Leu Glu Pro
        435                 440                 445             
Thr Leu Lys Pro Leu
    450             


<210> 7570
<211> 491
<212> PRT
<213> Homo sapiens

<400> 7570
Met Trp Ser Pro Glu Arg Glu Ala Glu Ala Pro Ala Gly Gly Asp Pro
 1               5                  10                  15      
Ala Gly Leu Leu Pro Pro Glu Trp Glu Glu Asp Glu Glu Arg Met Ser
            20                  25                  30          
Phe Leu Phe Ser Ala Phe Lys Arg Ser Arg Glu Val Asn Ser Thr Asp
        35                  40                  45              
Trp Asp Ser Lys Met Gly Phe Trp Ala Pro Leu Val Leu Ser His Ser
    50                  55                  60                  
Arg Arg Gln Gly Val Val Arg Leu Arg Leu Arg Asp Leu Gln Glu Ala
65                  70                  75                  80  
Phe Gln Arg Lys Gly Ser Val Pro Leu Gly Leu Ala Thr Val Leu Gln
                85                  90                  95      
Asp Leu Leu Arg Arg Gly Glu Leu Gln Arg Glu Ser Asp Phe Met Ala
            100                 105                 110         
Ser Val Asp Ser Ser Trp Ile Ser Trp Gly Val Gly Val Phe Leu Leu
        115                 120                 125             
Lys Pro Leu Lys Trp Thr Leu Ser Asn Met Leu Gly Asp Asn Lys Val
    130                 135                 140                 
Pro Ala Glu Glu Val Leu Val Ala Val Glu Leu Leu Lys Glu Lys Ala
145                 150                 155                 160 
Glu Glu Val Tyr Arg Leu Tyr Gln Asn Ser Pro Leu Ser Ser His Pro
                165                 170                 175     
Val Val Ala Leu Ser Glu Leu Ser Thr Leu Cys Ala Asn Ser Cys Pro
            180                 185                 190         
Asp Glu Arg Thr Phe Tyr Leu Val Leu Leu Gln Leu Gln Lys Glu Lys
        195                 200                 205             
Arg Val Thr Val Leu Glu Gln Asn Gly Glu Lys Ile Val Lys Phe Ala
    210                 215                 220                 
Arg Gly Pro Arg Ala Lys Val Ser Pro Val Asn Asp Val Asp Val Gly
225                 230                 235                 240 
Val Tyr Gln Leu Met Gln Ser Glu Gln Leu Leu Ser Arg Lys Val Glu
                245                 250                 255     
Ser Leu Ser Gln Glu Ala Glu Arg Cys Lys Glu Glu Ala Arg Arg Ala
            260                 265                 270         
Cys Arg Ala Gly Lys Lys Gln Leu Ala Leu Arg Ser Leu Lys Ala Lys
        275                 280                 285             
Gln Arg Thr Glu Lys Arg Ile Glu Ala Leu His Ala Lys Leu Asp Thr
    290                 295                 300                 
Val Gln Gly Ile Leu Asp Arg Ile Tyr Ala Ser Gln Thr Asp Gln Met
305                 310                 315                 320 
Val Phe Asn Ala Tyr Gln Ala Gly Val Gly Ala Leu Lys Leu Ser Met
                325                 330                 335     
Lys Asp Val Thr Val Glu Lys Ala Glu Ser Leu Val Asp Gln Ile Gln
            340                 345                 350         
Glu Leu Cys Asp Thr Gln Asp Glu Val Ser Gln Thr Leu Ala Gly Gly
        355                 360                 365             
Val Thr Asn Gly Leu Asp Phe Asp Ser Glu Glu Leu Glu Lys Glu Leu
    370                 375                 380                 
Asp Ile Leu Leu Gln Asp Thr Thr Lys Glu Pro Leu Asp Leu Pro Asp
385                 390                 395                 400 
Asn Pro Arg Asn Arg His Phe Thr Asn Ser Val Pro Asn Pro Arg Ile
                405                 410                 415     
Ser Asp Ala Glu Leu Glu Ala Glu Leu Glu Lys Leu Ser Leu Ser Glu
            420                 425                 430         
Glu Leu Val Pro Ser Ser Asn Leu Gln Lys Ala Ile Gly Thr Asp Ser
        435                 440                 445             
Lys Ala Ile Val Gly Pro Ser Ser Glu Gly Pro Ser Cys Lys Arg Glu
    450                 455                 460                 
Thr Arg Leu Ala Gly Cys Val His Ser Tyr Leu Asn Lys Lys Leu Ser
465                 470                 475                 480 
Glu Cys Val Trp Lys Arg Arg Lys Glu Asn His
                485                 490     


<210> 7571
<211> 286
<212> PRT
<213> Homo sapiens

<400> 7571
Met Glu Lys Tyr Leu Met Tyr Ser Ala Leu Thr Arg Ala Val Thr Leu
 1               5                  10                  15      
Ser Asp Glu Trp Thr Glu His Lys Ala Phe Ser Gln Lys Ser Phe Phe
            20                  25                  30          
Gln Phe Leu Thr Glu Asp Ile Pro Phe Phe Thr Ile Ala Leu Tyr Trp
        35                  40                  45              
Leu Pro Asn Ile Thr Leu Gln Ile Pro Gln Ser Ile Leu Ser Glu Ser
    50                  55                  60                  
Phe Arg Glu Thr Ala Leu Cys Ser Leu Asn Ser Ser His Gly Ile Val
65                  70                  75                  80  
Ala Phe Pro Ser Arg Ser Arg Ser Leu Arg Leu Phe Leu Trp Asn Ser
                85                  90                  95      
Gln Ile Asp Ile Trp Lys Pro Ile Glu Val Tyr Gly Ala Lys Gly Asn
            100                 105                 110         
Ile Leu Arg Glu Lys Leu Lys Arg Ile Phe Leu Gly Asn Cys Phe Val
        115                 120                 125             
Phe Cys Gly Phe Ile Ser Gln Ser Tyr Ser Phe Leu Leu Lys Lys Pro
    130                 135                 140                 
Phe Ala Lys Ala Val Ser Cys Gly Ile Cys Lys Val Val Phe Gly Ser
145                 150                 155                 160 
Pro Ser Arg Ala Arg Val Lys Lys Glu Ile Ser Ser Val Lys Thr Trp
                165                 170                 175     
Lys Glu Ala Ser Glu Asn Leu Leu Cys Val Leu Leu Ile His Leu Thr
            180                 185                 190         
Glu Leu Gln Leu Ser Pro Gln Glu Ala Val Tyr Tyr Gly Cys Ser Cys
        195                 200                 205             
Gly Ile Cys Lys Val Ile Phe Gly Ser Pro Glu Arg Ala Met Val Lys
    210                 215                 220                 
Lys Glu Thr Ser Tyr Asp Lys Asn Trp Lys Glu Ala Phe Cys Glu Thr
225                 230                 235                 240 
Ala Leu Cys Ser Val Asn Ser Ser His Arg Ile Thr Ala Phe Pro Ser
                245                 250                 255     
Arg Ser Leu Cys Leu Arg Leu Leu Leu Trp Asn Phe Gln Ser Asp Ile
            260                 265                 270         
Leu Lys Pro Leu Glu Ser Tyr Gly Glu Lys Gly Asn Ile Leu
        275                 280                 285     


<210> 7572
<211> 318
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 132
<223> Xaa = Any Amino Acid

<400> 7572
Met Glu Thr Ser Val Ile Glu Gly Gly Leu Asn Ile Thr Leu Thr Ile
 1               5                  10                  15      
Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys
            20                  25                  30          
Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Pro Ile Asn
        35                  40                  45              
Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Phe Ala Gly Pro
    50                  55                  60                  
Ala Asn Ala Val Phe Lys Gly Phe Ala Met Ile Ile Asp Lys Leu Glu
65                  70                  75                  80  
Glu Asp Ile Ser Ser Ser Met Thr Ser Ser Thr Ala Ala Thr Arg Pro
                85                  90                  95      
Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu
            100                 105                 110         
Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly
        115                 120                 125             
Ala Gln Val Xaa Met Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Gln
    130                 135                 140                 
Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys
145                 150                 155                 160 
Gln Ile Cys Val Val Met Leu Glu Ser Pro Pro Lys Gly Val Thr Ile
                165                 170                 175     
Pro Tyr Gln Leu Lys Pro Ser Ser Ser Pro Val Ile Phe Ala Gly Gly
            180                 185                 190         
Gln Ala Tyr Thr Leu Gln Gly Gln Phe Ala Ile Pro Gln Pro Asp Leu
        195                 200                 205             
Thr Met Leu His Gln Leu Ala Met Gln Gln Ser His Phe Pro Met Thr
    210                 215                 220                 
His Gly Asn Thr Gly Phe Ser Ala Gly Leu Asp Thr Ser Ala Gln Thr
225                 230                 235                 240 
Thr Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile
                245                 250                 255     
Gly Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala
            260                 265                 270         
Gln Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val
        275                 280                 285             
Thr Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile
    290                 295                 300                 
Asn Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser
305                 310                 315             


<210> 7573
<211> 276
<212> PRT
<213> Homo sapiens

<400> 7573
Met Gly Asn Ser Met Lys Ser Thr Pro Ala Pro Ala Glu Arg Pro Leu
 1               5                  10                  15      
Pro Asn Pro Glu Gly Leu Asp Ser Asp Phe Leu Ala Val Leu Ser Asp
            20                  25                  30          
Tyr Pro Ser Pro Asp Ile Ser Pro Pro Ile Phe Arg Arg Gly Glu Lys
        35                  40                  45              
Leu Arg Val Ile Ser Asp Glu Gly Gly Trp Trp Lys Ala Ile Ser Leu
    50                  55                  60                  
Ser Thr Gly Arg Glu Ser Tyr Ile Pro Gly Ile Cys Val Ala Arg Val
65                  70                  75                  80  
Tyr His Gly Trp Leu Phe Glu Gly Leu Gly Arg Asp Lys Ala Glu Glu
                85                  90                  95      
Leu Leu Gln Leu Pro Asp Thr Lys Val Gly Ser Phe Met Ile Arg Glu
            100                 105                 110         
Ser Glu Thr Lys Lys Gly Phe Tyr Ser Leu Ser Val Arg His Arg Gln
        115                 120                 125             
Val Lys His Tyr Arg Ile Phe Arg Leu Pro Asn Asn Trp Tyr Tyr Ile
    130                 135                 140                 
Ser Pro Arg Leu Thr Phe Gln Cys Leu Glu Asp Leu Val Asn His Tyr
145                 150                 155                 160 
Ser Glu Val Ala Asp Gly Leu Cys Cys Val Leu Thr Thr Pro Cys Leu
                165                 170                 175     
Thr Gln Ser Thr Ala Ala Pro Ala Val Arg Ala Ser Ser Ser Pro Val
            180                 185                 190         
Thr Leu Arg Gln Lys Thr Val Asp Trp Arg Arg Val Ser Arg Leu Gln
        195                 200                 205             
Glu Asp Pro Glu Gly Thr Glu Asn Pro Leu Gly Val Asp Glu Ser Leu
    210                 215                 220                 
Phe Ser Tyr Gly Leu Arg Glu Ser Ile Ala Ser Tyr Leu Ser Leu Thr
225                 230                 235                 240 
Ser Glu Asp Asn Thr Ser Phe Asp Arg Lys Lys Lys Ser Ile Ser Leu
                245                 250                 255     
Met Tyr Gly Gly Ser Lys Arg Lys Ser Ser Phe Phe Ser Ser Pro Pro
            260                 265                 270         
Tyr Phe Glu Asp
        275     


<210> 7574
<211> 275
<212> PRT
<213> Homo sapiens

<400> 7574
Gly Asn Ser Met Lys Ser Thr Pro Ala Pro Ala Glu Arg Pro Leu Pro
 1               5                  10                  15      
Asn Pro Glu Gly Leu Asp Ser Asp Phe Leu Ala Val Leu Ser Asp Tyr
            20                  25                  30          
Pro Ser Pro Asp Ile Ser Pro Pro Ile Phe Arg Arg Gly Glu Lys Leu
        35                  40                  45              
Arg Val Ile Ser Asp Glu Gly Gly Trp Trp Lys Ala Ile Ser Leu Ser
    50                  55                  60                  
Thr Gly Arg Glu Ser Tyr Ile Pro Gly Ile Cys Val Ala Arg Val Tyr
65                  70                  75                  80  
His Gly Trp Leu Phe Glu Gly Leu Gly Arg Asp Lys Ala Glu Glu Leu
                85                  90                  95      
Leu Gln Leu Pro Asp Thr Lys Val Gly Ser Phe Met Ile Arg Glu Ser
            100                 105                 110         
Glu Thr Lys Lys Gly Phe Tyr Ser Leu Ser Val Arg His Arg Gln Val
        115                 120                 125             
Lys His Tyr Arg Ile Phe Arg Leu Pro Asn Asn Trp Tyr Tyr Ile Ser
    130                 135                 140                 
Pro Arg Leu Thr Phe Gln Cys Leu Glu Asp Leu Val Asn His Tyr Ser
145                 150                 155                 160 
Glu Val Ala Asp Gly Leu Cys Cys Val Leu Thr Thr Pro Cys Leu Thr
                165                 170                 175     
Gln Ser Thr Ala Ala Pro Ala Val Arg Ala Ser Ser Ser Pro Val Thr
            180                 185                 190         
Leu Arg Gln Lys Thr Val Asp Trp Arg Arg Val Ser Arg Leu Gln Glu
        195                 200                 205             
Asp Pro Glu Gly Thr Glu Asn Pro Leu Gly Val Asp Glu Ser Leu Phe
    210                 215                 220                 
Ser Tyr Gly Leu Arg Glu Ser Ile Ala Ser Tyr Leu Ser Leu Thr Ser
225                 230                 235                 240 
Glu Asp Asn Thr Ser Phe Asp Arg Lys Lys Lys Ser Ile Ser Leu Met
                245                 250                 255     
Tyr Gly Gly Ser Lys Arg Lys Ser Ser Phe Phe Ser Ser Pro Pro Tyr
            260                 265                 270         
Phe Glu Asp
        275 


<210> 7575
<211> 6457
<212> PRT
<213> Homo sapiens

<400> 7575
Met Lys Ala Cys Ala Ser Phe Trp Lys Lys Pro Thr Leu Pro Glu Lys
 1               5                  10                  15      
Gly Ser Ser Asp Val Gln Glu Thr Glu Asp Ser Cys Pro Lys Ser Arg
            20                  25                  30          
Lys Leu Ala Pro Glu Asn Trp Ser Val Ile Asn Ser Ser Ser Gly Glu
        35                  40                  45              
Arg Val Gly Thr Phe Leu Glu Lys Arg Ile Thr Ser Ser Leu Thr Ser
    50                  55                  60                  
Glu Glu Lys Glu Cys Asn Phe Glu Asp Arg Ile Leu Phe Ser Arg Glu
65                  70                  75                  80  
Ile Leu Trp Ser Gly Thr Ser Glu Ser Glu Asp Gln Val Ser Pro Ser
                85                  90                  95      
Ser Glu Ser His Val Pro Ser Ser Asn Gly Ile Ser Ser Ser Leu Pro
            100                 105                 110         
Leu Phe Tyr Ser Glu Val Glu Glu Thr Cys Leu Ser His Thr Glu His
        115                 120                 125             
Pro Asp Arg Glu Tyr Glu Thr Ile Gln Phe Ser Ser Lys Lys Leu Phe
    130                 135                 140                 
Ser Met Met Lys Thr Asn Lys Asn Lys Asn Ser Gly Phe Ser Ser Asp
145                 150                 155                 160 
Leu Ser Phe Ser Ala Ser Arg Phe Thr Val Glu Asn Glu Asp Leu Asp
                165                 170                 175     
Val Ala Pro Cys Pro Leu Ala His Leu Phe Leu Ser Arg Asp Gln Val
            180                 185                 190         
Arg Leu Leu Glu Glu Asn Val Arg Asn Gln Ile Pro Ser Lys Pro Lys
        195                 200                 205             
Thr Lys Leu Gly Ser Arg Thr Thr Tyr Gln Cys Ser Arg Ser Gln Glu
    210                 215                 220                 
Ser Leu Asn Gln Asn Gln Pro Ser Val Gly Met Val Ile Ser Val Gln
225                 230                 235                 240 
Ala Gln Asp Ser Phe Pro Gly Gln Asn Ala Phe Gln Asn Gln Gly Leu
                245                 250                 255     
Tyr Glu Val Gln Phe Thr Ser Gln Ala Gln Tyr Ile Asn His Asn Gln
            260                 265                 270         
Glu Ser Ile Lys Ser Gln Pro Glu Ser Lys Ala Ser Asn Phe Ala Gln
        275                 280                 285             
Pro Glu Asp Val Met Lys Lys Pro Phe Ser Ser Ser Thr Gln Asp Ser
    290                 295                 300                 
Phe Gln Ser Gln Asp Leu Asp Arg Asn Gln His Phe Val Glu Val Pro
305                 310                 315                 320 
Ser Ile Val Glu Ala Lys Tyr Ser Val Lys Gly Leu Glu Ser Asp Glu
                325                 330                 335     
His Leu Gly Glu Asp Gln His Cys Val Trp Phe Ile Asp Ser Asn Lys
            340                 345                 350         
Val Lys Tyr Ser Ile Lys Gly Gln Asp Thr Ile Phe Lys Asn Ala Glu
        355                 360                 365             
Phe Leu Val Leu Thr Leu Asn Pro Asn Leu Val Thr Glu Asp Met Pro
    370                 375                 380                 
Gln Leu Arg Ser Val Lys Ala Gln Gly Gln Gln Gln Ile Val Ser Ser
385                 390                 395                 400 
Glu Leu Asn Gln Asp Ser Val Tyr Ser Ser Val Pro Leu Leu Ser Thr
                405                 410                 415     
Ile Lys Gly Gln Lys Asn Arg Arg Lys Thr Pro Asp Ser Lys Ser Lys
            420                 425                 430         
Leu Ser Leu Asn Val Pro Ser Leu Lys Ala Lys Lys Thr Pro Thr Ser
        435                 440                 445             
Gln Val Phe Gln Ile Thr Val Cys His Thr Leu Lys Asn Arg Asn Glu
    450                 455                 460                 
Leu Gly Cys Lys Asn Asn Thr Glu Lys Lys Glu Leu His Glu Arg Lys
465                 470                 475                 480 
Asp Ile Ser Asp Ile Ala Leu His Leu Ile Ser Val Ser Lys Leu Ile
                485                 490                 495     
Leu Pro Tyr Val Lys Asn Tyr Ser Arg Lys Gln Leu Val Lys Val Met
            500                 505                 510         
Pro Gly Leu Ile Lys Cys Gly His Phe Leu Gln Lys Gln Asn Lys Ser
        515                 520                 525             
Pro Asp Thr Glu Lys Ile Asn Tyr Ala Gly Pro Leu Glu Glu Thr Gly
    530                 535                 540                 
Ile Ser Asp Ile Thr Lys Lys Glu Lys Glu Tyr Asp Lys Glu Asn Lys
545                 550                 555                 560 
Arg Leu Lys Asn Ile Ser Pro Lys Met Leu Pro Gln Leu Glu Gln Ser
                565                 570                 575     
Phe Met Val Asn Thr Val Gln Leu Lys Ala Pro Cys Leu Leu Val Glu
            580                 585                 590         
Thr Asn Gly Lys Ser Lys Glu Ser Leu Lys Asp Ser Ile Thr Gln Ala
        595                 600                 605             
Lys Gly Ile Gly Ile Thr Glu Phe His Val Leu Asn Ser Lys Lys Pro
    610                 615                 620                 
Phe Asp Leu His Ile Pro Lys His Lys Thr Ser Leu Glu Glu Ala Ile
625                 630                 635                 640 
Ser Lys Pro Met Gln Lys Leu Val Ser Ser Pro Glu Met Glu Ser Asn
                645                 650                 655     
Asn Arg Met Lys Ile Gln Glu Asp Leu Gln Ser Ser Glu Asn Ser His
            660                 665                 670         
Leu Gln Leu Ser Asn Gly Glu Glu Leu Pro Thr Ser Thr Pro Lys Thr
        675                 680                 685             
Gln Arg Cys Phe Pro Arg Glu Asn Thr Gln Lys Gln Lys Asp Phe Leu
    690                 695                 700                 
Glu Leu Val Leu Glu Leu Ser Asn Val Gly Leu Leu Ile Ser Pro Gly
705                 710                 715                 720 
Ser Lys Met His Lys Ser Ser Glu Glu Leu Glu Ala Ile Lys Ile Gln
                725                 730                 735     
Val Asn Thr Glu Ser Val Asn Leu Lys Glu Ser Lys Pro Leu Ile Leu
            740                 745                 750         
Asn Val Thr Glu Asp Ser Asp Leu Arg Glu Ser Glu Glu Leu Glu Cys
        755                 760                 765             
Asn Thr Gly Ser Asn Ile Thr Asn Met His Gln Asp Lys Glu Thr Ser
    770                 775                 780                 
Asp Ala Phe His Ser Ala Thr Tyr Thr Thr Ile Ser Gln Leu Pro Asp
785                 790                 795                 800 
Thr Glu Thr His Ser Ile Ser Lys Ala Lys Ala Asp Thr Leu Arg Ile
                805                 810                 815     
Ile Arg Leu Ser His Ser Ala Ser Lys Gln Glu Lys Leu Pro Asp Glu
            820                 825                 830         
Lys Glu Thr Gln Asn Ala Glu Tyr Ile Asp Lys Ser Cys Thr Phe Lys
        835                 840                 845             
Lys Pro Gln Gln Cys Asp Arg Lys Glu Gln Glu Lys Glu Ala Asn Ser
    850                 855                 860                 
Glu Leu Thr Gln Gly Phe Arg Phe Ser Ile His Leu Lys Gln Lys Pro
865                 870                 875                 880 
Lys Tyr Val Lys Phe Gln Met Glu Gln Ile Ser Ser Gly Ser Ser Lys
                885                 890                 895     
Ala Pro Asn Lys Glu Gln Glu Val Gln Pro Gln Thr Leu Ser Thr Gln
            900                 905                 910         
Thr Ile Leu Glu Asn Ser Pro Cys Pro Met Met Asp Pro Phe Gln Val
        915                 920                 925             
Glu Lys Val Lys Gln Ser Thr Asp Arg Pro Thr Asp Arg Glu Ser Ala
    930                 935                 940                 
Gly Asp Pro Lys Asn Pro Leu Thr Met Pro Glu Asn Leu Pro Val Gly
945                 950                 955                 960 
Glu Leu Leu Ile Glu Thr Thr Glu Tyr Ser Val Pro Phe Gly Gly Asn
                965                 970                 975     
Leu Gln Lys Thr Thr Asp Ser His Ile Ala Glu Glu Lys Glu Asp Val
            980                 985                 990         
Lys Arg Tyr Leu Pro Ala Val Ala Leu Gly Ser Phe Asn Asn His Leu
        995                 1000                1005            
Leu Thr Leu Pro Tyr Phe Lys Arg Gln Glu Ile Lys Lys Lys Leu Ser
    1010                1015                1020                
Glu Thr Lys Ser Val Leu Ser Val Lys Tyr Val Ile Met Lys Val Lys
1025                1030                1035                1040
Lys Pro Ala Ile Ser Leu Met Pro Tyr Ile Asn Ile Cys Gly Thr Ser
                1045                1050                1055    
Asn His Arg Lys Lys Met Gly Gly Asn Phe Glu Ile Ile Ile Lys Gln
            1060                1065                1070        
Ile Leu Gln Asp Lys Ile Ala Ala Gly Met Leu Leu Asn Val Ile Tyr
        1075                1080                1085            
Pro Pro Met Ser Ile Leu Pro Asn Thr Arg Met Tyr Ser Arg Leu Asn
    1090                1095                1100                
Ala Glu Asn His Ser His Ile Lys Leu Val Gln Glu Glu Ser Gln Ile
1105                1110                1115                1120
Glu Arg Glu Glu Lys Tyr Pro Tyr Phe Ile Asn Glu Gly Asn Glu Ser
                1125                1130                1135    
Gln Asn Thr Leu Asp Ala Lys Leu Gln Asp Glu Val Lys Gly Val Lys
            1140                1145                1150        
Glu Thr Leu Pro Lys Ala Val Leu His Asp Ser Cys Asn Leu Gly Leu
        1155                1160                1165            
Asp Ala His Leu Glu Lys Glu Ile Lys Thr Glu Lys Glu Met His Gln
    1170                1175                1180                
Pro Ile Pro Phe Thr Glu Thr Ile Ile Glu Ser Val Val Ser Pro Ile
1185                1190                1195                1200
Met Glu Leu Ser His Ala Glu Asn Val Lys Ser Thr Gln Lys Thr Gln
                1205                1210                1215    
Thr Asp Cys Lys Cys Thr Ala Asp Ser Glu Thr Pro Ser Pro Ile Ser
            1220                1225                1230        
Gly Lys Ser Leu Ile Gly Asp Pro Leu Asn Gln Thr Arg Glu Ser Tyr
        1235                1240                1245            
Ile Pro Ser Asn Gly Ser Asp Thr Arg Glu Met Gly Tyr Cys Phe Ala
    1250                1255                1260                
Glu Glu Lys Thr Glu Ile Pro Lys Asp Leu Pro Ala Thr Ser Pro Glu
1265                1270                1275                1280
Thr Phe Asn Tyr Cys Thr Pro Val Leu Ser Cys Ser Lys Val Met Lys
                1285                1290                1295    
Lys Arg Val Thr Phe Ala Leu Thr Thr Ser Thr Ala Lys Pro Lys Cys
            1300                1305                1310        
Val Asn Thr Lys Ala Val Lys Pro Ser Ile Ser Glu Thr Val Ser Val
        1315                1320                1325            
Thr Ser His Arg Lys Lys Ser Glu Leu Asp Phe Lys Thr Lys Phe Lys
    1330                1335                1340                
Lys Ile Asn Gln Thr Lys Gly Leu Val Pro Glu Cys Leu Asn Thr Leu
1345                1350                1355                1360
Cys Ser Pro Met His Ser Arg Leu Gln Arg Glu Phe Cys Leu Pro Ala
                1365                1370                1375    
Ser Gln Leu Lys Gln Gly Glu Thr Ala Asp Lys Thr Tyr Thr Asp Val
            1380                1385                1390        
Phe Ala Lys Asn Ser Ile Ser His Asp Arg Glu Glu Lys Leu Gln Asp
        1395                1400                1405            
Gly Lys Glu Glu Glu His Lys Val Leu Leu Glu Ala Ala Pro Gln Leu
    1410                1415                1420                
Ser Gln His Leu Gly Ser Glu Ala Gly Gln Met Lys Glu Ile His Leu
1425                1430                1435                1440
Glu Ser Asp Pro Val Leu Asn Cys Leu Thr Leu Glu Leu His Ile Asn
                1445                1450                1455    
Gly Gln Arg Leu Gln His Gln Thr Gly Phe Glu Gln Thr Thr Leu Glu
            1460                1465                1470        
Thr Ser Leu Gln Met Gly Pro Leu Glu Ala Glu Glu Leu Gln Lys Ala
        1475                1480                1485            
Asn Glu Thr Glu Asn Asp Ile Lys Val Leu Gly Gly Pro Lys Ile Pro
    1490                1495                1500                
Pro Pro Lys Ala Leu Gln Ala Leu Glu Asn Ser Asp Gly Leu Ile Leu
1505                1510                1515                1520
Asn Ala Tyr Gln Lys Asp Asn Glu Leu Val Lys Ser Asp Glu Glu Leu
                1525                1530                1535    
Asn Gln Pro Gly Ser Thr Asn Ile Gln Val Gln Pro Gln Thr His Phe
            1540                1545                1550        
Thr Gln Thr Ile Leu Lys Ser Thr Ser Cys Pro Thr Leu Asp Gln Phe
        1555                1560                1565            
Pro Phe Glu Lys Val Glu Ser His Val Arg Phe Ser Pro Leu Lys Ser
    1570                1575                1580                
Gly Glu Ala Lys Val Asp Glu Ile Ile Phe Tyr Ala Arg Glu Gly Gly
1585                1590                1595                1600
Ile Ser Ser Asp Ser Ser His Gln Lys Glu Gln Ala Gly Gly Thr Glu
                1605                1610                1615    
Lys Lys Glu Thr Ala Ile Phe Gly Ser Cys Met Pro Ala Leu Ser Thr
            1620                1625                1630        
Pro Lys Thr Thr Arg Asn Leu Lys Gln Phe Ser Asp Met Lys Thr Leu
        1635                1640                1645            
Val Asn Pro Lys Cys Gly Ile Ile Lys Ala Lys Lys Pro Ser Ile Ser
    1650                1655                1660                
Tyr Met Leu Asn Ile Arg Ala Gly Ala Gly Pro Lys Arg Arg Lys Glu
1665                1670                1675                1680
Leu Ser Cys Asn Leu Thr Thr Lys Met Lys Glu Leu His Gln Gly Lys
                1685                1690                1695    
Lys Gly Val Asp Glu Thr Tyr Ala Phe Leu Thr Met Thr Pro Asp Ile
            1700                1705                1710        
Asn Lys Tyr Ser Lys Val Glu Thr Glu Lys Asp Thr Leu Arg Glu Lys
        1715                1720                1725            
Arg Leu Ser Ser Thr Gln Val Lys Gln Asp Thr Ser Pro His Glu Asp
    1730                1735                1740                
Ser Ile Thr Ser Arg Asp Ile Lys Glu Thr Leu Leu Gln Asp Glu Glu
1745                1750                1755                1760
Gln Glu Glu Arg Lys Gln Glu Ala Leu Leu Lys Val Ile Pro Gln His
                1765                1770                1775    
Leu Gln His Phe Met Phe Arg Ser Gly Gln Gly Lys Asp Leu Asp Phe
            1780                1785                1790        
His Lys Leu Glu Asn Gln Gly Ser Arg Lys Ile Leu Phe Val Thr Lys
        1795                1800                1805            
Gln Asp Val Pro Gln Gln Leu Gln Pro Ala Glu Pro Ile Gln Arg Glu
    1810                1815                1820                
Glu Thr Lys Lys Cys Leu Gln Thr Gln Asn Gly Thr Ile Cys Thr Val
1825                1830                1835                1840
Asn Ser Lys Leu Leu Pro Leu Lys Ser Glu Asp Ser Val Asn Gly Glu
                1845                1850                1855    
Val Leu Thr Gly Ala Ile Lys Arg Gly Val Pro Thr Asp Arg Lys Cys
            1860                1865                1870        
Met Gly Glu Gln His Asn Ser Gly Lys Gly Glu Lys Ala Glu Phe Asn
        1875                1880                1885            
Lys Asp Leu Gln Ala Thr Val Leu Glu Leu Gln Lys Ser Pro His Gly
    1890                1895                1900                
Gly Glu Ala Gln Lys Ala Asn Leu Thr Asp Met Glu Ser Gly Ser Ser
1905                1910                1915                1920
Asn Ala Met Asn Met Asn Val Gln His Glu Arg Glu Asp Lys Asn Ile
                1925                1930                1935    
Gln Lys Met Leu Thr Glu Ser Val Pro Cys Tyr Ser Gln His Leu Arg
            1940                1945                1950        
Phe Ser Thr His Gln Met Lys Asp Pro Asp Pro Cys Lys Ser Gly Ser
        1955                1960                1965            
Glu Pro Lys Ser Pro Glu Gly Arg Ser Trp Asn Leu Ser His Ile Val
    1970                1975                1980                
Gln Lys Thr Lys Gln Glu Thr His Phe Arg Glu Thr Val Leu Glu Pro
1985                1990                1995                2000
Ile Ser Gly Tyr Met Met Lys Gln Ser Pro His Met Gln Glu Gly Ile
                2005                2010                2015    
Lys Cys Met Glu Gly Leu Lys Thr Ser Phe Pro Lys Thr Gly Lys Ser
            2020                2025                2030        
Lys Ile Gly Ser Ile Pro Arg Asp Thr Pro Trp Asp Glu Asn Pro Arg
        2035                2040                2045            
Arg Lys Trp Asp Ser Ser Ile Ser Glu Lys Thr Ala Trp Asn Gln Lys
    2050                2055                2060                
Asn Leu Gln Thr Val Leu Lys Pro Leu Asp Phe Ser Ser Leu Met Ser
2065                2070                2075                2080
Ser Glu Tyr Glu Ser Arg Ser Tyr Thr Leu Glu Phe Ile Gly Lys Lys
                2085                2090                2095    
Ser Met Ser Pro Lys Cys Val Thr Leu Lys Ala Lys Gln Leu Arg Ile
            2100                2105                2110        
Leu Gln Leu Phe Asn Ile Ile Arg Tyr Ser Thr Glu Asn His Arg Lys
        2115                2120                2125            
Lys Lys Gln His Arg Phe Lys Tyr Lys Met Lys Gly Lys Gln Trp Tyr
    2130                2135                2140                
Thr Ser Ile Gly Glu Ala Leu Leu Ser Ala Thr Glu Tyr Ala Lys Ser
2145                2150                2155                2160
Thr Thr Ser Lys Ser Met Ile Asp Lys Leu Leu Tyr Asn Thr Ala Ala
                2165                2170                2175    
Arg Cys Ile Leu Ser Asn Arg Thr Arg Arg Gln Asn Leu Asp Gly His
            2180                2185                2190        
Ile Thr Glu Glu Lys Glu Glu Val Gln Glu Asn Val Ala Ala Ile Phe
        2195                2200                2205            
Leu Gly Leu Leu Asp Phe Phe Met Pro Val Leu Ser Asp Ser Lys Asn
    2210                2215                2220                
Gln Arg Asn Thr Ala Gln Leu Ser Glu Lys Glu Ile Ile Phe Asn Ala
2225                2230                2235                2240
Lys Cys Leu Thr Met Lys Glu Lys Lys Ser Ser Ile Ser Gln Ile His
                2245                2250                2255    
Lys Ile Asn Arg Glu Ser Thr Arg Lys His Arg Lys Lys Cys Lys Ser
            2260                2265                2270        
Tyr Leu Lys Thr Val Ser Asn Arg Lys Cys Gln Glu Asn His Gly His
        2275                2280                2285            
Ile Thr Glu Glu Glu Glu Glu Val Gln Glu Asn Ser Pro Ala Thr Phe
    2290                2295                2300                
Leu Gly Pro Leu Asp Phe Phe Met Pro Val Leu Ser Asp Ser Lys Asn
2305                2310                2315                2320
Gln Ile Asn Thr Ile Gln Leu Ser Glu Arg Lys Ile Ile Leu Asn Pro
                2325                2330                2335    
Lys Cys Leu Thr Met Lys Glu Lys Lys Pro Pro Ile Ser Gln Ile His
            2340                2345                2350        
Lys Ile Ser Gly Gln Phe Thr Thr Lys His Arg Lys Lys Leu Glu Ser
        2355                2360                2365            
Asn Leu Lys Thr Lys Leu Lys Ala Met Trp Gln Gly Glu Asn Val Ala
    2370                2375                2380                
Asp Thr Phe Pro Asn Thr Thr Ser Phe Thr Pro Asp Ser Ser Asp Ile
2385                2390                2395                2400
Lys Arg Gln Ser Gly Phe Gln Thr Glu Ile Asp Met Arg Ile Ser Gly
                2405                2410                2415    
Leu Ser His Thr Gln Pro Thr Gln Ile Glu Ser Leu Ala Glu Gly Ile
            2420                2425                2430        
Ala Arg Tyr Ser Asp Pro Ile Asp Lys Arg Arg Thr Ser Asn Leu Val
        2435                2440                2445            
Lys Gly Ala Lys Leu His Asp Arg Glu Ser Gly Glu Glu Lys Gln Glu
    2450                2455                2460                
His Leu Thr Glu Met Asp Pro Phe Tyr Ala Glu Asn Phe Met Ala Asn
2465                2470                2475                2480
Thr Tyr Leu Arg Lys Asp Arg His Leu Gly Lys Ser Glu Asp Val Leu
                2485                2490                2495    
Leu Gly Glu Thr Phe Phe Ser Lys Ser Gln Ile Tyr Lys Gly Asn Ser
            2500                2505                2510        
Glu Lys Asn Val Lys Ile Glu Lys Asn Lys Asn Gly Lys Glu Ser Leu
        2515                2520                2525            
Lys Val Gly Leu Ala Arg Met Glu Lys Ser Asp Asn Cys Ala Glu Leu
    2530                2535                2540                
Ser Glu Ala Thr Asp Asp Ala Ile Ser Asn Lys Tyr Asp Lys Gln Asn
2545                2550                2555                2560
Ile Gly His Ser Val Leu Lys Glu Asn Ala Phe Cys Asn Leu Ala Ala
                2565                2570                2575    
Ile Val Pro Asp Ser Val Gly Arg His Ser Pro Ala Ser Glu Glu Met
            2580                2585                2590        
Lys Arg Gln Asn Gly Arg Leu Lys Met Ala Asp Arg Ser Ser Pro Gln
        2595                2600                2605            
Gly Arg Pro Leu Gln Ala Lys Gln Ser Ala Val Ser Gln Ser Pro Asp
    2610                2615                2620                
Thr Ala Gly Tyr Ala Val Val Ser Asn Asn Lys Glu Gln Lys Gln Asn
2625                2630                2635                2640
Phe Lys Ala Gln Lys Thr Glu Ala Glu Val Asp Leu Ile Asp Gln Glu
                2645                2650                2655    
Ala Lys Ile Asn Val Ala Glu Glu Phe Asn Pro Glu Ser Val Phe Phe
            2660                2665                2670        
Ser Lys Ile His Pro Leu Gln Ile Glu Asn Lys Lys Glu Phe Lys Thr
        2675                2680                2685            
Ala Asp Trp Lys Thr Arg Ala Asp Pro Lys Thr Phe Ala Leu Pro Lys
    2690                2695                2700                
Lys Gln Gln Glu Leu Cys Val Ser Gly Thr Ile Trp Ser Tyr Pro Asn
2705                2710                2715                2720
Pro Tyr Thr Ser Ile Ser Pro Lys Ile Ile Arg His Lys Asp Lys Ala
                2725                2730                2735    
Lys Thr Ala Asp Val Glu Ser Thr Met His Thr Lys Gln Ile Lys Leu
            2740                2745                2750        
Lys Ala Lys Arg Ile Thr Val Ser Gln Leu Leu Glu Tyr Gly Thr Ala
        2755                2760                2765            
Ser Asn Lys Lys Glu Leu Arg Gly Asn Ile Gln Gln Gln Lys Ser Phe
    2770                2775                2780                
Gln Leu Ser Lys Asn Ala Val His Arg Val Leu Lys Ala Val Tyr Asp
2785                2790                2795                2800
Ser Gly Tyr Cys Val Ser Ser Ile Lys Lys Leu Thr Glu Val Lys Met
                2805                2810                2815    
Glu Lys Asp Lys Pro Lys Asp Arg Thr Cys Ile Leu Pro Gln Pro Lys
            2820                2825                2830        
Leu Glu Lys Pro Leu Lys Glu Met Gln Arg Ser Leu Ser Gly Cys Thr
        2835                2840                2845            
Asp Met Ser Ser Ile Leu Arg Lys Gln Glu Gln Asp Ile Arg Glu Lys
    2850                2855                2860                
Glu Gln Lys His Gln Ser Ile Ser Glu Asp Ile Ser Gln Tyr Tyr Ile
2865                2870                2875                2880
Gly Pro Leu Arg Ile Ser Ser Gln Gln Ile Asn Tyr Ser Ser Phe Asp
                2885                2890                2895    
Ala Pro Arg Ile Arg Thr Asp Glu Glu Leu Glu Phe Leu Ile Ala Gln
            2900                2905                2910        
Arg Ala Lys Glu Lys Asp Val Gly Ile Ala Lys His Ser Val Ser Ile
        2915                2920                2925            
Pro Trp Glu Arg Glu Gly Ser Lys Arg Leu Asp Ile Pro Leu Asn Ser
    2930                2935                2940                
Lys Gly Gln Asn Ile Phe Phe Thr Glu Leu Asp Thr Ser Gln Gln Lys
2945                2950                2955                2960
Thr Cys Gln Glu Gln Glu Leu Leu Lys Gln Glu Asp Ile Ser Met Thr
                2965                2970                2975    
Asn Leu Gly Ser Met Ala Cys Pro Ile Met Glu Pro Leu His Leu Glu
            2980                2985                2990        
Asn Thr Gly Lys Val Thr Glu Glu Glu Asp Val Tyr Ile Asn Arg Lys
        2995                3000                3005            
Ile Ser Ser His Val Leu Gly Lys Glu Gly Leu Lys Glu Thr Asp Ile
    3010                3015                3020                
Phe Val Gly Ser Lys Gly Gln Lys Phe Leu Cys Thr Asn Ser Glu Val
3025                3030                3035                3040
Gln His Lys Val Pro Ala Glu Gln Lys Glu Gln Val Asn Pro Asp His
                3045                3050                3055    
Val Pro Glu Ser Ile Leu Asp Ser Glu Ser Phe Leu Ser Lys Asp Pro
            3060                3065                3070        
Leu His Leu Lys Gln Ala Val Asn Thr Ala Arg Lys Glu Asn Val Thr
        3075                3080                3085            
Ile Ser Glu Ser Phe Asn Glu Asn Leu Trp Gly Lys Glu Gln Ser Lys
    3090                3095                3100                
Leu Asp Ile Thr Leu Lys Ser Asn Arg Gln Lys Met Asp Phe Ser Lys
3105                3110                3115                3120
Lys Leu Arg Met Lys His Leu Ser Asn Tyr Tyr Gln Asn Lys Glu Asn
                3125                3130                3135    
Ile Leu Glu Ser Val Leu Pro Cys Ile Leu His Gln Leu Tyr Ile Glu
            3140                3145                3150        
Asn Pro Lys Lys Glu Gly Ser Ala Glu Glu Ile Met Ser Ser Lys Val
        3155                3160                3165            
Leu Ser Pro Met Val Glu Lys Ala Ser His Glu Val Gly Ile Pro Val
    3170                3175                3180                
Asp Gln Pro Pro Cys Ser Glu Gly Ile His Leu Asn Ile Lys Gly Arg
3185                3190                3195                3200
Lys Glu His Pro Gln Glu Ser Thr His Glu Ala Phe Pro Ala Ser Val
                3205                3210                3215    
Ser His Ser Leu Met Asp Val Leu Gln Ile Lys Ser Pro Lys Val Lys
            3220                3225                3230        
Lys Ala Leu Lys Ala Ile Asn Ser Leu Gly Tyr Leu Thr Ser Asn Thr
        3235                3240                3245            
Lys Gly Ile Gly Leu Leu Phe Pro Arg Gln Ala Glu Lys Glu Glu Lys
    3250                3255                3260                
Tyr Thr Tyr Lys Ala Leu Pro Lys Pro Ala Ser His Ser Lys Thr Asp
3265                3270                3275                3280
Leu Phe Gln Phe Asn Ala Ser Met Gln Gln Glu Lys Leu Asp Ala Met
                3285                3290                3295    
Asp Ile Pro His Tyr Asp Tyr Leu Thr Ser Gln Thr Arg Glu Ala Val
            3300                3305                3310        
Lys Gln Met Asp Val Ile Val Gly Tyr Thr Gln Asn Ser Lys Lys Arg
        3315                3320                3325            
Gln Asp Leu Leu Lys Thr Gly Gln Lys Trp Gln Tyr Leu Pro Ile Ser
    3330                3335                3340                
Tyr Glu Asn Phe Trp Glu His Ile Ser Cys Pro Gln Lys Tyr Pro Cys
3345                3350                3355                3360
Leu Leu Gln His Leu Met Pro Gln Glu Lys Glu Ala Leu Ser Glu Gly
                3365                3370                3375    
Gly Asn Leu Ser Ser Arg Thr Pro Gly Leu Asp Leu Phe Ser Ala Asp
            3380                3385                3390        
Gln Leu Ser Thr Ile Thr Lys Asn Arg Leu Glu Trp Ile Val Pro Leu
        3395                3400                3405            
Ile Ser Pro Arg Gln Met Lys Lys Gln Asp Ser Met Leu Pro Leu Gly
    3410                3415                3420                
Ser Tyr His Lys Thr Ile Lys Tyr Ala Ser Leu Leu Phe Pro Lys Gly
3425                3430                3435                3440
Met Lys Ser Ser Asp Gly Val Gln Val Phe Asp Leu Ile Ser Asn Asn
                3445                3450                3455    
Ser Ser Pro Lys Leu Arg Leu Gly Lys Lys Ile Glu Thr Gln Lys Ala
            3460                3465                3470        
Asn Glu Lys Val Gln Lys Glu Val Cys Leu Pro Ile Thr Leu His Ser
        3475                3480                3485            
Leu Ser Ala Ser Met Pro Ile Leu Gln Glu Ser Lys Gly Gln Lys Asp
    3490                3495                3500                
Ser Val Glu Gln Val Ile Arg Lys Gly Val Ile Cys His Lys Arg Arg
3505                3510                3515                3520
Thr Ser Lys Trp Lys Lys Ser Val Phe Ser His Ile Leu Asn Thr Ser
                3525                3530                3535    
Asp Cys Gly Ala Ser Ser Asn Arg Leu Glu Met Gln Trp Asn Met Thr
            3540                3545                3550        
Asp Lys Met Val Asn Val Lys His Arg Met Ser Glu Ile Asp Leu Val
        3555                3560                3565            
Ala Ala Lys Ile Tyr Ile Ile Lys Gln Glu Gly Lys Met Gln Glu Gly
    3570                3575                3580                
Lys Gly Lys Ser Ser Met Lys Leu Thr Asn Leu Cys Thr Ser Leu Pro
3585                3590                3595                3600
Ser Leu Ser His Ser Asn Ser Asn Ser Arg Thr Lys Ala Gly Lys Asp
                3605                3610                3615    
Lys Ser Gly Thr Leu Lys Gly Cys Leu Pro Pro Leu Lys Leu Gln Ala
            3620                3625                3630        
Ser Ser Asn Ala Arg Arg Val Ser Ser Ala Glu Ser Ile Asn Arg Asp
        3635                3640                3645            
Ser Leu Ser Asn Val Ile Glu Ser Lys Cys Phe Pro Gln Lys Lys Lys
    3650                3655                3660                
Glu Asp Arg Glu Asn Ile Val Asp Val Lys Asp Val Met Gly Leu Lys
3665                3670                3675                3680
Cys Ile Thr Leu Lys Gly Lys Lys Ser Leu Phe Arg His Leu Leu His
                3685                3690                3695    
Gly Lys Glu Pro Gln Arg Ser Asn Lys Lys Leu Glu Lys Met Thr Gln
            3700                3705                3710        
Glu Asp Glu Ser Asn Leu Asn Val Val Gln Asn Lys Leu Cys Ala Ser
        3715                3720                3725            
Ile Leu Ser Pro Pro His Leu Glu Trp Asn Pro Arg Ile Lys Glu Val
    3730                3735                3740                
Tyr Met Arg Gly Ile Thr Arg Phe Cys Leu Ser Ser Ser Thr Gln Gln
3745                3750                3755                3760
Glu Leu Ser Asp Thr Met Glu Lys Cys Glu Gln Pro Ile Asp Asp Ser
                3765                3770                3775    
Leu Ser Ser Ile Glu Lys Ala Lys His Met Pro Gln Lys Asp Lys Asp
            3780                3785                3790        
Arg Val Glu Lys Ala Leu Glu Lys Ile Met His Ser Lys Arg Ile Ala
        3795                3800                3805            
Leu Glu Val Lys Gln Pro Ser Ile Phe Gln Glu Leu Glu Leu Asn Ile
    3810                3815                3820                
Lys Glu Lys Gly Gly Lys Ile Gln Glu Asp Lys Glu Val Glu Ile Trp
3825                3830                3835                3840
Ser Lys Pro Phe Ala Ser Ile Ser Phe Leu Pro Tyr Ser Lys Val Gly
                3845                3850                3855    
Thr Ile Glu Gly Glu Glu Ala Met Arg Ile Lys Met Arg Ser Ser Phe
            3860                3865                3870        
Ser Gln Pro Asn Leu Gln Glu Ser Ser Asp Thr Glu Lys Thr Ala Tyr
        3875                3880                3885            
Glu Lys Cys Ile Ser Asp Asn Ile Ser Asn Ser Val Lys Lys Ala Leu
    3890                3895                3900                
Glu Ser Ile Leu Gln Lys Glu Gln Arg Gln Lys Met Glu Lys Ile Arg
3905                3910                3915                3920
Ala Leu Lys Lys Met Lys Ser Ser Ile Ser Gln Gly Ile Gln Leu Asp
                3925                3930                3935    
Ile Lys Glu Gln Glu Lys Arg Ile Glu His Ile Lys Gly Glu Pro Ser
            3940                3945                3950        
Val Leu Leu Thr Asn Ala Cys Ala Ser Ile Pro Ser Pro Ser His Leu
        3955                3960                3965            
Gln Leu Asp Thr Arg Arg Glu Lys Ala Glu Tyr Val Thr Glu Ile Thr
    3970                3975                3980                
Arg Tyr Tyr Leu Pro Glu Leu Ser His Gln Lys Ser Ser Glu Ala Gly
3985                3990                3995                4000
Glu Lys Ala Asp Gly Val Ala Ser Lys Gly Asp Ile Thr Ile Lys Val
                4005                4010                4015    
Gln Lys Ala Lys Asp Tyr Met Gln Gln Lys Glu Asp Asp Glu Val Lys
            4020                4025                4030        
Ile Ser Ala Lys Lys Asp Ile Met His Pro Glu Asp Lys Asp Lys Arg
        4035                4040                4045            
Thr Ala Gly Lys Lys Glu Glu Gln Gly Val Thr Arg Ser Phe Leu Pro
    4050                4055                4060                
Pro Ser Trp His Met Glu Ser Ser Asp Thr Gly Lys Leu Lys Tyr Thr
4065                4070                4075                4080
Leu Ser Tyr Leu Asn Asp Ile Thr Gly Asp Ser Asn Arg Thr Lys Tyr
                4085                4090                4095    
Met Ala Gln Ile Gln Lys Asp Lys Ala Asn Ile Ser Glu Lys Ser Val
            4100                4105                4110        
Met His Pro Glu Tyr Ile Ala Val Lys Ala Glu Lys Ser Pro Leu Ser
        4115                4120                4125            
His Ile Leu Lys Thr Lys Glu Leu Gln Val Asn Ile Ser Gln Gln Gly
    4130                4135                4140                
Glu Lys Ala Gln Glu Gly Glu Val Glu Ile Val Val Leu Leu Ser Lys
4145                4150                4155                4160
Thr Cys Pro Phe Val Thr Ser Ser Ala Phe Leu Glu Leu Asp Ser Ile
                4165                4170                4175    
Lys Glu Glu Glu Gly Glu Pro Arg Ile Thr Arg Ser Phe Met Pro His
            4180                4185                4190        
Leu Glu Ile Gln Glu Ser Leu Pro Ser Arg Gln Thr Ala Pro Thr Lys
        4195                4200                4205            
Pro Thr Glu Ser Leu Val Lys Lys Glu Lys Gln Leu Leu Pro Gln Lys
    4210                4215                4220                
Glu Asp Arg Val Gln Thr Val Ser Met His Gly Leu Met His Pro Asn
4225                4230                4235                4240
Gly Ala Val Phe Lys Ala Lys Thr Ser Ala Pro Pro Gln Val Phe Ser
                4245                4250                4255    
Ile Thr Glu His Ser Pro Leu Ser Lys Arg Lys Glu Pro Gln Trp Gly
            4260                4265                4270        
Met Lys Glu Arg Ala Gly Gln Lys Gln Asp Arg Thr Gly Arg Pro His
        4275                4280                4285            
Val Ile Leu Thr Lys Thr His Pro Phe Met Pro Ser Leu Ser His His
    4290                4295                4300                
Arg Phe Ser Pro Ser Gln Pro Lys Leu Pro Ile Ser Ser Gly Ala Gly
4305                4310                4315                4320
Lys Ser Arg Leu Ala Asn Ser Asn Glu Gly Ile Ser Ser His Lys Val
                4325                4330                4335    
Ile Leu Lys Ala Asn Gln Gln Met Pro Tyr Lys Glu Ala Lys Asp Arg
            4340                4345                4350        
Val Lys Ile Glu Gly Arg Glu Gly Arg Ile Leu Pro Lys Arg Ile His
        4355                4360                4365            
Leu Arg Ala Glu Ala Leu Pro Leu Ala Leu Leu Cys Asn Gly Lys Asn
    4370                4375                4380                
Tyr Ser Leu His Ile Glu Glu Gln Gly Glu Gly Val Gln Glu Ser Lys
4385                4390                4395                4400
Lys Glu Pro Gly Val Val Pro Arg Lys Ser Ala Ser Phe Pro Pro Pro
                4405                4410                4415    
Pro Phe Tyr Leu Asn Cys Asp Thr Arg Arg Asn Glu Lys Glu Gly Thr
            4420                4425                4430        
Leu Gly Lys Thr Gln Phe Ser Phe Pro Pro Leu Lys Ile Gln Asp Ser
        4435                4440                4445            
Ser Asp Ser Gly Lys Lys Ala Tyr Thr Glu Ser Leu His Gly Tyr Thr
    4450                4455                4460                
Leu Ser Asn Ser Lys Gly Pro Val Gln Pro Thr Ala Gln Gly Glu Glu
4465                4470                4475                4480
Lys Gly Gly Leu Arg Ile Asp Met Glu Asp Lys Met Leu Pro Lys Cys
                4485                4490                4495    
Thr Asp Leu Lys Ala Lys Gln Leu Leu Leu Ser Asp Ile Leu Asn Thr
            4500                4505                4510        
Lys Lys Leu Gln Trp Lys Ser Lys Glu Gln Lys Arg Lys Ile Gln Glu
        4515                4520                4525            
Asp Lys Asn Lys Gln Val Lys Gly Leu Pro Ser Ile Asn Thr Ser Leu
    4530                4535                4540                
Leu Thr Pro Pro Tyr Leu Lys Phe Asp Thr Thr Glu Gly Gln Glu Asn
4545                4550                4555                4560
Val Ile Arg Ile Ala Lys Val Ser Leu Pro Gln Ser Arg Ser Lys Glu
                4565                4570                4575    
Ser Ser Asp Ala Gly Arg Ile Ala Cys Pro Glu Ala Thr His Gly Glu
            4580                4585                4590        
Leu Ser Ser Asp Val Lys Gln Leu Lys Ala His Leu Leu Gln Lys Glu
        4595                4600                4605            
Glu Lys Asp Arg Glu Lys Val Ala Asp Met Thr Ser Val Leu Asp Pro
    4610                4615                4620                
Asn Lys Met Tyr Leu Lys Ala Lys Lys Ser Pro Val Leu His Thr His
4625                4630                4635                4640
Ser Phe Ser Asp Leu Gln Trp Lys Thr Arg Glu Gln Glu Glu Glu Lys
                4645                4650                4655    
Val Gln Lys Val Lys Ser Gly Pro Gly Val Met Leu Ser Lys Ser Pro
            4660                4665                4670        
Ser Arg Ser Ser Pro Leu His Leu Asn Val Asn Thr Gly Phe Gln Glu
        4675                4680                4685            
Glu Ser Ile Pro Ile Leu Thr Arg Pro Ser Phe Pro Leu Val Lys Leu
    4690                4695                4700                
Gln Val Ser Pro Asp Thr Glu Gly Gly Thr Cys Ile Arg Pro Ile Ala
4705                4710                4715                4720
Gly Asp Ile Leu Ile Tyr Leu Gln Lys Gly Lys His Val Ser Gln Asn
                4725                4730                4735    
Lys Glu Glu Asp Asp Val Gln Ile Val Ser Ile Leu Ile Phe Pro Lys
            4740                4745                4750        
His Gln Glu Glu Lys Val Gln Glu Cys Glu Gly Glu Pro Gly Val Val
        4755                4760                4765            
Leu Thr Lys Ser Thr Ser Leu Pro Ser Leu Ser Gln Leu Glu Leu Asp
    4770                4775                4780                
Lys Glu Thr His Leu Gly Asn Glu Met Leu Arg Leu Lys Arg Pro Ile
4785                4790                4795                4800
Leu Arg Arg Ile Ser His Ile Gly Glu Thr Val His Arg Glu Ser Val
                4805                4810                4815    
Val Gly Asp Ile Pro Lys Asp Val Lys Asn Glu Lys Gln His Ile Pro
            4820                4825                4830        
Gln Lys Glu Glu Arg Asn Gln Lys Lys Ile Ile Asp Met Arg Gly Thr
        4835                4840                4845            
Asp Ile Thr Leu Lys Ser Lys Lys Ser Pro Arg Ser Cys Met Leu His
    4850                4855                4860                
Arg Thr Glu Leu His Val Asn Ile Gly Gly Gln Gly Arg Lys Glu His
4865                4870                4875                4880
Glu Gly Gln Asp Lys Pro Pro Gly Met Ile Gln Arg Lys Met Cys Ile
                4885                4890                4895    
Leu Phe Ser Lys Pro Leu Pro Ser Asn Leu Lys Leu Glu Arg Ala Thr
            4900                4905                4910        
His Ala Asp Glu Glu Arg Leu Gly Gly Lys Thr Ser Phe Val Leu Pro
        4915                4920                4925            
Leu Met Pro Ser Ala Leu Pro Asp Thr Glu Lys Thr Ala Asp Ala Glu
    4930                4935                4940                
Ala Arg Ser Gly Asp Val Arg Lys Gly Lys Pro His Arg Ser Gln Lys
4945                4950                4955                4960
Glu Asn Arg His Glu Val Lys Thr Ile Asp Met Arg Phe Arg Ile His
                4965                4970                4975    
Cys Gln Glu Ala Arg Ile Ser Pro Met Ser His Ile Leu Asn Ala Lys
            4980                4985                4990        
Glu Leu Val Leu Asn Ile Asn Lys Leu Glu Lys Lys Val His Lys Asp
        4995                5000                5005            
Lys Asp Glu Ala Cys Val Val Leu Ser Arg Thr Phe Leu Ser Ile Pro
    5010                5015                5020                
Ser Ala Pro Pro Leu Tyr Leu Asp Ser Gly Asn Lys Thr Asp Lys Asp
5025                5030                5035                5040
Thr Pro Gly Ile Thr Gly Ser Ser Cys Pro Gln Arg Thr Leu His Val
                5045                5050                5055    
Pro Ser Asn Thr Gln Lys Ile Thr Asn Arg Asp Ser Val Glu Gly Val
            5060                5065                5070        
Asp Lys Asn Val Val Lys Gln Ala Glu Gln Tyr Val Pro Arg Pro Glu
        5075                5080                5085            
Ala Glu Gln Gln Leu Thr Ser Asn Phe Met Ile Ser Val Gln Gln Arg
    5090                5095                5100                
Asn Gln Pro Ser Arg Val Arg Lys Ile Ser Lys Glu Leu Tyr Val Thr
5105                5110                5115                5120
Leu Gly Thr Pro Ala Asn Ser Lys Gly Phe Ser Val Ser Glu Arg Tyr
                5125                5130                5135    
Ala His Gln Gln Glu Thr Ser Ser Lys Val Ser Pro Glu Leu Ala Gly
            5140                5145                5150        
Ser Cys Lys Phe Asp Lys Pro Lys Glu Asp Gly Gln Ser Asn Asp Arg
        5155                5160                5165            
Ile Ser Lys Met Phe Ser Pro Lys Val Leu Ala Pro Gln Thr Lys Gly
    5170                5175                5180                
Ser Leu Lys Lys Ile Ser Ile Val Thr Asn Trp Asn Ala Pro Gln Asn
5185                5190                5195                5200
Ile Glu Glu Gln Asp Ile Val Met Lys Lys Gln Val Ile Arg Arg Cys
                5205                5210                5215    
Glu His Gly His Lys Thr Arg Thr Asn Thr Ile Leu Ser Lys Phe Pro
            5220                5225                5230        
Leu Gln Ser Gly Lys Gln Lys Thr Pro Ser Glu Thr Asp Val Asp Lys
        5235                5240                5245            
Lys Thr Thr Ala His Leu Ser Leu Gln Met Leu Pro Gly Ile His Met
    5250                5255                5260                
Asp Met Thr Glu Ile Asp Pro Ala Lys Gly Gly Arg Lys Gln Ala Leu
5265                5270                5275                5280
Leu Ile Ser Glu Gln Glu Glu Gly Val Leu Glu Phe Leu Pro Lys Ser
                5285                5290                5295    
Leu Phe Pro Pro Trp Thr Phe Gln Phe Gln Ser Gly Asp Leu Glu Glu
            5300                5305                5310        
Lys His Gln Thr Asp Ala Asn Thr Asn Ile Asn Leu Glu Gln Lys Lys
        5315                5320                5325            
Leu Glu Met Asp Asn Asp Ser Thr Val Asn Gln Lys Glu Gly Lys Leu
    5330                5335                5340                
Lys Ile Gly Thr Asn Arg Ala Leu His Leu Gln Glu Glu Lys Thr Glu
5345                5350                5355                5360
Met His Lys Ala Arg Thr Ala Asn Leu Glu Lys Glu Arg Gly Arg Met
                5365                5370                5375    
Asp Thr Ser Ser Ser Ala His Pro His Leu Leu Ser Leu Lys Ala Glu
            5380                5385                5390        
Glu Ser Gln Met Lys Thr Gln Val Ile Thr His Arg Glu Asn Ser Arg
        5395                5400                5405            
Leu Ile Met Gln Lys Gln Lys Lys Glu Leu Glu Ala Ser Asn Ala Lys
    5410                5415                5420                
Gln Ser Ile Gln Leu Gln Lys Leu Phe Gln Arg Asn Val Leu Asp Ser
5425                5430                5435                5440
Phe Tyr Ser Tyr Val Pro Leu Ser Pro Lys Arg Lys Asp Gln Lys Gly
                5445                5450                5455    
Arg Leu Thr Ile Arg Asp Leu Lys Arg Glu Leu Ser Thr Lys Tyr Leu
            5460                5465                5470        
Thr Met Lys Ile Gln Asn His Pro Ile Pro Gln Met Leu Asn Ile Thr
        5475                5480                5485            
Gly Arg Gly Thr Pro Ser Asn Arg Lys Lys Leu Glu Tyr Asp Val Lys
    5490                5495                5500                
Leu Lys Asn Ile Ala Ser Trp Ser Lys Asp Val Ser Gly Ile Phe Ile
5505                5510                5515                5520
Arg Ser Leu Ser Ile Ser Ile Met Arg Ser Pro His Thr Asp Pro Lys
                5525                5530                5535    
Thr Asn Leu Glu Arg Glu Lys Arg Ile Cys Leu Pro Lys Phe Gln Glu
            5540                5545                5550        
Lys Ser Pro Asn Thr Ser Glu Met Ser Lys Arg Asp Thr Leu Thr Ile
        5555                5560                5565            
Val Lys Gly Glu Gln Asn Phe Thr Asn Thr Val Pro Gln Asp Pro Gln
    5570                5575                5580                
Pro Phe Ala Val Asp Lys Gln Gln Met Gln Lys Leu Pro Asn Val Lys
5585                5590                5595                5600
Ser Glu Ala Asn Leu Arg Ser Glu Met Asn Lys Lys Tyr Leu Lys Ala
                5605                5610                5615    
Gln Thr Lys Glu Arg Ile Val Pro Glu His Asp Val Ser Arg Ile Ile
            5620                5625                5630        
Lys Lys Pro Asp Leu Arg Ile Ile Glu Gln Glu Glu Lys Ile Leu Lys
        5635                5640                5645            
Arg Ile Leu Thr Pro Thr Glu Cys Pro Ser Met Leu Glu Asp Pro Lys
    5650                5655                5660                
Leu Pro Lys Gln Arg Asp Gln Ser Glu Pro Val Trp Asp Met Thr Thr
5665                5670                5675                5680
Gln Lys Val Gln Gln Gln Lys Ala Phe Pro Gly Thr Val Pro Ile Pro
                5685                5690                5695    
Pro Gln Val Lys Ser Ser Glu Val Lys Ile Val Ala Asp Ser Thr Asn
            5700                5705                5710        
Ala Glu His Leu Leu Pro Ile Cys Glu Ala Thr Lys Ala Ile Ser Glu
        5715                5720                5725            
Ser Gln Val Lys Asn Met Ile Gln Asp Lys Val Ser Ser Asp Lys Leu
    5730                5735                5740                
Asp Asn Ile Gln Ala Tyr Lys Pro Asp Asp Leu Lys Ser Pro Pro Phe
5745                5750                5755                5760
Pro Glu Gly Pro Asp Thr Ile Ser Thr Ala Ile Tyr Pro Lys Thr Gln
                5765                5770                5775    
His Lys Ser Leu Leu Glu Gln Phe Thr Pro Lys Glu Lys Asn Lys Leu
            5780                5785                5790        
Thr Ser His Leu Glu Ser Lys Ala Leu Glu Ile Gln Leu Asn Leu Ile
        5795                5800                5805            
Pro Glu Met Ala Arg Lys Ser Leu Gln Met Phe Asn Phe Tyr Pro Lys
    5810                5815                5820                
Gly Thr Ile Ser Lys Asp Asn Ser Trp Arg Phe Tyr Ser Arg His Lys
5825                5830                5835                5840
Thr Met Asn Phe Met Ser Leu Glu Gly Thr Asp Thr Ile Glu Pro Asn
                5845                5850                5855    
Ser Lys His Lys His Gln Lys Asp Ser Pro Leu Ala Ser Asn Met Lys
            5860                5865                5870        
Thr Leu Ile Val Asp Val Ser Ser Asp Ser Glu Glu Thr Ile Thr Lys
        5875                5880                5885            
Leu Gln Ser Ile Asn Lys Leu Glu Asn Gly Thr Ser Ala Val Thr Ser
    5890                5895                5900                
Ala Ser Glu Met Leu Leu Pro His Thr Leu Gln Asn His Ser Val Lys
5905                5910                5915                5920
Glu Lys Gly Lys Leu Leu Met His Phe Ser Val Lys Thr Leu Glu Ile
                5925                5930                5935    
Gln Met Lys Ala Phe Pro Arg Ile Val Arg Glu Ser Tyr Ala Met Thr
            5940                5945                5950        
Ser Ala His Glu Arg Lys Lys Pro Leu Ser Asn Cys Ile His Pro Gly
        5955                5960                5965            
Phe Thr Gly Pro Lys Arg Gln Asn Arg Ile Leu Leu Leu Ser Glu Glu
    5970                5975                5980                
Lys Ser Leu His Gln Ile Asp Leu Asp Leu Gln Tyr Lys Tyr Leu Arg
5985                5990                5995                6000
Phe Leu Leu Gly Leu Pro Val Gly Ser Thr Phe Pro Lys Pro Asn Val
                6005                6010                6015    
Leu Pro Lys His Ser Lys Leu Asn Thr Ile Ala Val Cys Lys Asn Val
            6020                6025                6030        
Asn Ala Gly Gly Gln Ser Gly Ser Leu Ser Ile Asp Thr Glu Leu Leu
        6035                6040                6045            
Glu Gln His Ile Ser Phe Lys Lys Gln Ser Pro His Glu Asn Ser Ser
    6050                6055                6060                
Leu Ile Arg Lys Phe Pro Gln Pro Thr Leu Val Cys Ala Ser Asp Arg
6065                6070                6075                6080
Asp Leu His Ser Pro Arg Lys Lys Asp Thr Gln Val Leu Ser Glu Ser
                6085                6090                6095    
Glu Phe His Val Thr Pro Glu Lys Asn Lys Gln Tyr His Val Trp Phe
            6100                6105                6110        
Gln Glu Arg Asn Thr Cys Glu Ser Val Asp Leu Arg Thr Gln Arg Asn
        6115                6120                6125            
Ala Thr Gly Ser Ala Val Ser Cys Glu Thr Gln Ile Ser Glu Asp Phe
    6130                6135                6140                
Val Asp Ile Gln Thr Asp Ile Glu Ser Pro Ala Asp Leu Asp Glu Cys
6145                6150                6155                6160
Ser Cys Leu Glu Val Ser Glu Ser Glu Glu Cys Val Phe Leu Glu Ala
                6165                6170                6175    
Asn Ser Tyr Leu Ser Gln Glu Ser Glu Asn Ile Leu Phe Glu Leu Gln
            6180                6185                6190        
Thr Gly Ile Pro Leu Glu Asn Val Tyr Lys Ile Thr Thr Asp Leu Lys
        6195                6200                6205            
Ser Phe Tyr Ser Glu Asp Ser Gly Ser His Cys Thr Arg Glu Cys Arg
    6210                6215                6220                
Lys Glu Thr Leu Ile Ile Thr Pro Pro Ser Cys Lys Ser His Lys Ser
6225                6230                6235                6240
Arg Lys Tyr Arg Ser Ser Ser Lys Met Lys Ser Pro Asp Trp Leu Cys
                6245                6250                6255    
His Ser Ser Ser Asn Thr Ala Glu Ile Gln Ser Arg Ser Ser Ser Val
            6260                6265                6270        
Ser Phe Ser Glu Glu Lys Ile Ser Trp Thr Thr Lys Ser Arg Thr Ser
        6275                6280                6285            
Tyr Ser Ser Ala Pro Leu Thr Glu Ser Asn Ile Lys Ser His Leu Ala
    6290                6295                6300                
Lys Asn Gln Gly Lys Ser His Arg His Pro Glu Ser Gln Glu Arg Lys
6305                6310                6315                6320
Lys Ala Arg Ser Asp Leu Phe Arg Lys Asn Ser Ser His Trp Asp His
                6325                6330                6335    
Asp Tyr Ser Cys Thr His Ser Lys Gly Lys Arg Asp Arg Lys Lys Arg
            6340                6345                6350        
Val Tyr Asp Tyr Glu Ser Glu Arg Leu Asp Cys Phe Gln Ser Lys His
        6355                6360                6365            
Lys Ser Ala Ser Lys Pro His His Asp Asp Ile Asn Phe Tyr Ser Glu
    6370                6375                6380                
Arg Lys Gln Asn Arg Pro Phe Phe Phe Ala Cys Val Pro Ala Asp Ser
6385                6390                6395                6400
Leu Glu Val Ile Pro Lys Thr Ile Arg Trp Thr Ile Pro Pro Glu Thr
                6405                6410                6415    
Leu Arg Lys Arg Asn Phe Arg Ile Pro Leu Val Ala Lys Ile Ser Ser
            6420                6425                6430        
Ser Trp Asn Ile Trp Ser Ser Ser Lys Lys Leu Leu Gly Ser Leu Ser
        6435                6440                6445            
Gly Ser Leu Thr Thr Val Phe His Ser
    6450                6455        


<210> 7576
<211> 1539
<212> PRT
<213> Homo sapiens

<400> 7576
Met Asp Ser Tyr Phe Lys Ala Ala Val Ser Asp Leu Asp Lys Leu Leu
 1               5                  10                  15      
Asp Asp Phe Glu Gln Asn Pro Asp Glu Gln Asp Tyr Leu Gln Asp Val
            20                  25                  30          
Gln Asn Ala Tyr Asp Ser Asn His Cys Ser Val Ser Ser Glu Leu Ala
        35                  40                  45              
Ser Ser Gln Arg Thr Ser Leu Leu Pro Lys Asp Gln Glu Cys Val Asn
    50                  55                  60                  
Ser Cys Ala Ser Ser Glu Thr Ser Tyr Gly Thr Asn Glu Ser Ser Leu
65                  70                  75                  80  
Asn Glu Lys Thr Leu Lys Gly Leu Thr Ser Ile Gln Asn Glu Lys Asn
                85                  90                  95      
Val Thr Gly Leu Asp Leu Leu Ser Ser Val Asp Gly Gly Thr Ser Asp
            100                 105                 110         
Glu Ile Gln Pro Leu Tyr Met Gly Arg Cys Ser Lys Pro Ile Cys Asp
        115                 120                 125             
Leu Ile Ser Asp Met Gly Asn Leu Val His Ala Thr Asn Ser Glu Glu
    130                 135                 140                 
Asp Ile Lys Lys Leu Leu Pro Asp Asp Phe Lys Ser Asn Ala Asp Ser
145                 150                 155                 160 
Leu Ile Gly Leu Asp Leu Ser Ser Val Ser Asp Thr Pro Cys Val Ser
                165                 170                 175     
Ser Thr Asp His Asp Ser Asp Thr Val Arg Glu Gln Gln Asn Asp Thr
            180                 185                 190         
Ser Ser Glu Leu Gln Asn Arg Glu Ile Gly Gly Ile Lys Glu Leu Gly
        195                 200                 205             
Ile Lys Val Asp Thr Thr Leu Ser Asp Ser Tyr Asn Tyr Ser Gly Thr
    210                 215                 220                 
Glu Asn Leu Lys Asp Lys Lys Ile Phe Asn Gln Leu Glu Ser Ile Val
225                 230                 235                 240 
Asp Phe Asn Met Ser Ser Ala Leu Thr Arg Gln Ser Ser Lys Met Phe
                245                 250                 255     
His Ala Lys Asp Lys Leu Gln His Lys Ser Gln Pro Cys Gly Leu Leu
            260                 265                 270         
Lys Asp Val Gly Leu Val Lys Glu Glu Val Asp Val Ala Val Ile Thr
        275                 280                 285             
Ala Ala Glu Cys Leu Lys Glu Glu Gly Lys Thr Ser Ala Leu Thr Cys
    290                 295                 300                 
Ser Leu Pro Lys Asn Glu Asp Leu Cys Leu Asn Asp Ser Asn Ser Arg
305                 310                 315                 320 
Asp Glu Asn Phe Lys Leu Pro Asp Phe Ser Phe Gln Glu Asp Lys Thr
                325                 330                 335     
Val Ile Lys Gln Ser Ala Gln Glu Asp Ser Lys Ser Leu Asp Leu Lys
            340                 345                 350         
Asp Asn Asp Val Ile Gln Asp Ser Ser Ser Ala Leu His Val Ser Ser
        355                 360                 365             
Lys Asp Val Pro Ser Ser Leu Ser Cys Leu Pro Ala Ser Gly Ser Met
    370                 375                 380                 
Cys Gly Ser Leu Ile Glu Ser Lys Ala Arg Gly Asp Phe Leu Pro Gln
385                 390                 395                 400 
His Glu His Lys Asp Asn Ile Gln Asp Ala Val Thr Ile His Glu Glu
                405                 410                 415     
Ile Gln Asn Ser Val Val Leu Gly Gly Glu Pro Phe Lys Glu Asn Asp
            420                 425                 430         
Leu Leu Lys Gln Glu Lys Cys Lys Ser Ile Leu Leu Gln Ser Leu Ile
        435                 440                 445             
Glu Gly Met Glu Asp Arg Lys Ile Asp Pro Asp Gln Thr Val Ile Arg
    450                 455                 460                 
Ala Glu Ser Leu Asp Gly Gly Asp Thr Ser Ser Thr Val Val Glu Ser
465                 470                 475                 480 
Gln Glu Gly Leu Ser Gly Thr His Val Pro Glu Ser Ser Asp Cys Cys
                485                 490                 495     
Glu Gly Phe Ile Asn Thr Phe Ser Ser Asn Asp Met Asp Gly Gln Asp
            500                 505                 510         
Leu Asp Tyr Phe Asn Ile Asp Glu Gly Ala Lys Ser Gly Pro Leu Ile
        515                 520                 525             
Ser Asp Ala Glu Leu Asp Ala Phe Leu Thr Glu Gln Tyr Leu Gln Thr
    530                 535                 540                 
Thr Asn Ile Lys Ser Phe Glu Glu Asn Val Asn Asp Ser Lys Ser Gln
545                 550                 555                 560 
Met Asn Gln Ile Asp Met Lys Gly Leu Asp Asp Gly Asn Ile Asn Asn
                565                 570                 575     
Ile Tyr Phe Asn Ala Glu Ala Gly Ala Ile Gly Glu Ser His Gly Ile
            580                 585                 590         
Asn Ile Ile Cys Glu Thr Val Asp Lys Gln Asn Thr Ile Glu Asn Gly
        595                 600                 605             
Leu Ser Leu Gly Glu Lys Ser Thr Ile Pro Val Gln Gln Gly Leu Pro
    610                 615                 620                 
Thr Ser Lys Ser Glu Ile Thr Asn Gln Leu Ser Val Ser Asp Ile Asn
625                 630                 635                 640 
Ser Gln Ser Val Gly Gly Ala Arg Pro Lys Gln Leu Phe Ser Leu Pro
                645                 650                 655     
Ser Arg Thr Arg Ser Ser Lys Asp Leu Asn Lys Pro Asp Val Pro Asp
            660                 665                 670         
Thr Ile Glu Ser Glu Pro Ser Thr Ala Asp Thr Val Val Pro Ile Thr
        675                 680                 685             
Cys Ala Ile Asp Ser Thr Ala Asp Pro Gln Val Ser Phe Asn Ser Asn
    690                 695                 700                 
Tyr Ile Asp Ile Glu Ser Asn Ser Glu Gly Gly Ser Ser Phe Val Thr
705                 710                 715                 720 
Ala Asn Glu Asp Ser Val Pro Glu Asn Thr Cys Lys Glu Gly Leu Val
                725                 730                 735     
Leu Gly Gln Lys Gln Pro Thr Trp Val Pro Asp Ser Glu Ala Pro Asn
            740                 745                 750         
Cys Met Asn Cys Gln Val Lys Phe Thr Phe Thr Lys Arg Arg His His
        755                 760                 765             
Cys Arg Ala Cys Gly Lys Val Phe Cys Gly Val Cys Cys Asn Arg Lys
    770                 775                 780                 
Cys Lys Leu Gln Tyr Leu Glu Lys Glu Ala Arg Val Cys Val Val Cys
785                 790                 795                 800 
Tyr Glu Thr Ile Ser Lys Ala Gln Ala Phe Glu Arg Met Met Ser Pro
                805                 810                 815     
Thr Gly Ser Asn Leu Lys Ser Asn His Ser Asp Glu Cys Thr Thr Val
            820                 825                 830         
Gln Pro Pro Gln Glu Asn Gln Thr Ser Ser Ile Pro Ser Pro Ala Thr
        835                 840                 845             
Leu Pro Val Ser Ala Leu Lys Gln Pro Gly Val Glu Gly Leu Cys Ser
    850                 855                 860                 
Lys Glu Gln Lys Arg Val Trp Phe Ala Asp Gly Ile Leu Pro Asn Gly
865                 870                 875                 880 
Glu Val Ala Asp Thr Thr Lys Leu Ser Ser Gly Ser Lys Arg Cys Ser
                885                 890                 895     
Glu Asp Phe Ser Pro Leu Ser Pro Asp Val Pro Met Thr Val Asn Thr
            900                 905                 910         
Val Asp His Ser His Ser Thr Thr Val Glu Lys Pro Asn Asn Glu Thr
        915                 920                 925             
Gly Asp Ile Thr Arg Asn Glu Ile Ile Gln Ser Pro Ile Ser Gln Val
    930                 935                 940                 
Pro Ser Val Glu Lys Leu Ser Met Asn Thr Gly Asn Glu Gly Leu Pro
945                 950                 955                 960 
Thr Ser Gly Ser Phe Thr Leu Asp Asp Asp Val Phe Ala Glu Thr Glu
                965                 970                 975     
Glu Pro Ser Ser Pro Thr Gly Val Leu Val Asn Ser Asn Leu Pro Ile
            980                 985                 990         
Ala Ser Ile Ser Asp Tyr Arg Leu Leu Cys Asp Ile Asn Lys Tyr Val
        995                 1000                1005            
Cys Asn Lys Ile Ser Leu Leu Pro Asn Asp Glu Asp Ser Leu Pro Pro
    1010                1015                1020                
Leu Leu Val Ala Ser Gly Glu Lys Gly Ser Val Pro Val Val Glu Glu
1025                1030                1035                1040
His Pro Ser His Glu Gln Ile Ile Leu Leu Leu Glu Gly Glu Gly Phe
                1045                1050                1055    
His Pro Val Thr Phe Val Leu Asn Ala Asn Leu Leu Val Asn Val Lys
            1060                1065                1070        
Phe Ile Phe Tyr Ser Ser Asp Lys Tyr Trp Tyr Phe Ser Thr Asn Gly
        1075                1080                1085            
Leu His Gly Leu Gly Gln Ala Glu Ile Ile Ile Leu Leu Leu Cys Leu
    1090                1095                1100                
Pro Asn Glu Asp Thr Ile Pro Lys Asp Ile Phe Arg Leu Phe Ile Thr
1105                1110                1115                1120
Ile Tyr Lys Asp Ala Leu Lys Gly Lys Tyr Ile Glu Asn Leu Asp Asn
                1125                1130                1135    
Ile Thr Phe Thr Glu Ser Phe Leu Ser Ser Lys Asp His Gly Gly Phe
            1140                1145                1150        
Leu Phe Ile Thr Pro Thr Phe Gln Lys Leu Asp Asp Leu Ser Leu Pro
        1155                1160                1165            
Ser Asn Pro Phe Leu Cys Gly Ile Leu Ile Gln Lys Leu Glu Ile Pro
    1170                1175                1180                
Trp Ala Lys Val Phe Pro Met Arg Leu Met Leu Arg Leu Gly Ala Glu
1185                1190                1195                1200
Tyr Lys Ala Tyr Pro Ala Pro Leu Thr Ser Ile Arg Gly Arg Lys Pro
                1205                1210                1215    
Leu Phe Gly Glu Ile Gly His Thr Ile Met Asn Leu Leu Val Asp Leu
            1220                1225                1230        
Arg Asn Tyr Gln Tyr Thr Leu His Asn Ile Asp Gln Leu Leu Ile His
        1235                1240                1245            
Met Glu Met Gly Lys Ser Cys Ile Lys Ile Pro Arg Lys Lys Tyr Ser
    1250                1255                1260                
Asp Val Met Lys Val Leu Asn Ser Ser Asn Glu His Val Ile Ser Ile
1265                1270                1275                1280
Gly Ala Ser Phe Ser Thr Glu Ala Asp Ser His Leu Val Cys Ile Gln
                1285                1290                1295    
Asn Asp Gly Ile Tyr Glu Thr Gln Ala Asn Ser Ala Thr Gly His Pro
            1300                1305                1310        
Arg Lys Val Thr Gly Ala Ser Phe Val Val Phe Asn Gly Ala Leu Lys
        1315                1320                1325            
Thr Ser Ser Gly Phe Leu Ala Lys Ser Ser Ile Val Glu Asp Gly Leu
    1330                1335                1340                
Met Val Gln Ile Thr Pro Glu Thr Met Asn Gly Leu Arg Leu Ala Leu
1345                1350                1355                1360
Arg Glu Gln Lys Asp Phe Lys Ile Thr Cys Gly Lys Val Asp Ala Val
                1365                1370                1375    
Asp Leu Arg Glu Tyr Val Asp Ile Cys Trp Val Asp Ala Glu Glu Lys
            1380                1385                1390        
Gly Asn Lys Gly Val Ile Ser Ser Val Asp Gly Ile Ser Leu Gln Gly
        1395                1400                1405            
Phe Pro Ser Glu Lys Ile Lys Leu Glu Ala Asp Phe Glu Thr Asp Glu
    1410                1415                1420                
Lys Ile Val Lys Cys Thr Glu Val Phe Tyr Phe Leu Lys Asp Gln Asp
1425                1430                1435                1440
Leu Ser Ile Leu Ser Thr Ser Tyr Gln Phe Ala Lys Glu Ile Ala Met
                1445                1450                1455    
Ala Cys Ser Ala Ala Leu Cys Pro His Leu Lys Thr Leu Lys Ser Asn
            1460                1465                1470        
Gly Met Asn Lys Ile Gly Leu Arg Val Ser Ile Asp Thr Asp Met Val
        1475                1480                1485            
Glu Phe Gln Ala Gly Ser Glu Gly Gln Leu Leu Pro Gln His Tyr Leu
    1490                1495                1500                
Asn Asp Leu Asp Ser Ala Leu Ile Pro Val Ile His Gly Gly Thr Ser
1505                1510                1515                1520
Asn Ser Ser Leu Pro Leu Glu Ile Glu Leu Val Phe Phe Ile Ile Glu
                1525                1530                1535    
His Leu Phe
            


<210> 7577
<211> 1778
<212> PRT
<213> Homo sapiens

<400> 7577
Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr
 1               5                  10                  15      
Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro
            20                  25                  30          
Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser
        35                  40                  45              
Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His
    50                  55                  60                  
Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro
65                  70                  75                  80  
Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn
                85                  90                  95      
Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly
            100                 105                 110         
Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp
        115                 120                 125             
Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile
    130                 135                 140                 
Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys
145                 150                 155                 160 
Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu
                165                 170                 175     
Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr
            180                 185                 190         
Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His
        195                 200                 205             
Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn
    210                 215                 220                 
Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys
225                 230                 235                 240 
Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys
                245                 250                 255     
Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly
            260                 265                 270         
Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn
        275                 280                 285             
Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala
    290                 295                 300                 
Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp
305                 310                 315                 320 
Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile
                325                 330                 335     
Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp
            340                 345                 350         
Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe
        355                 360                 365             
Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe
    370                 375                 380                 
Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe
385                 390                 395                 400 
Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu
                405                 410                 415     
Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser
            420                 425                 430         
Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe
        435                 440                 445             
Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu
    450                 455                 460                 
Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn
465                 470                 475                 480 
Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Met Thr Arg
                485                 490                 495     
Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu
            500                 505                 510         
Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala
        515                 520                 525             
Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp
    530                 535                 540                 
Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro
545                 550                 555                 560 
Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg
                565                 570                 575     
Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser
            580                 585                 590         
Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser
        595                 600                 605             
Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr
    610                 615                 620                 
Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu
625                 630                 635                 640 
Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn
                645                 650                 655     
Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly
            660                 665                 670         
Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala
        675                 680                 685             
Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr
    690                 695                 700                 
Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu
705                 710                 715                 720 
Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys
                725                 730                 735     
Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu
            740                 745                 750         
His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val
        755                 760                 765             
Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu
    770                 775                 780                 
Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu
785                 790                 795                 800 
Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala
                805                 810                 815     
Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr
            820                 825                 830         
Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys
        835                 840                 845             
Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn
    850                 855                 860                 
Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile
865                 870                 875                 880 
Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met
                885                 890                 895     
Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu
            900                 905                 910         
Gln Glu Ile Lys Thr Ile Gly Tyr Thr Ser Pro Arg Ser Arg Thr Glu
        915                 920                 925             
Val Asn Arg Gln Cys Pro Gly Glu Lys Glu Pro Val Ser Asp Leu Gln
    930                 935                 940                 
Leu Gly Leu Asp Ala Val Glu Pro Thr Ala Leu His Lys Thr Leu Glu
945                 950                 955                 960 
Thr Pro Ala His Asp Arg Ala Glu Pro Asn Ser Gln Leu Asp Ser Thr
                965                 970                 975     
His Ser Gly Arg Gly Thr Met Tyr Ser Ser Trp Val Lys Ser Pro Asp
            980                 985                 990         
Arg Thr Gly Val Asn Phe Ser Val Asn Ser Asn Leu Arg Asp Leu Thr
        995                 1000                1005            
Pro Ser His Gln Leu Glu Val Gly Gly Gly Phe Arg Ile Ser Glu Ser
    1010                1015                1020                
Lys Cys Leu Met Gln Asp Asp Thr Arg Gly Met Phe Met Glu Thr Thr
1025                1030                1035                1040
Val Phe Cys Thr Ser Glu Asp Gly Leu Val Ser Gly Phe Gly Arg Thr
                1045                1050                1055    
Val Asn Asp Asn Leu Ile Asp Gly Asn Cys Thr Pro Gln Asn Pro Pro
            1060                1065                1070        
Gln Lys Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg Gln Arg Glu
        1075                1080                1085            
Ala Arg Lys Ser Gly Ser Lys Thr Glu Asn Phe Pro Leu Ile Ser Val
    1090                1095                1100                
Ser Pro His Ala Ser Gly Ser Leu Ser Asn Asn Gly Asp Gly Cys Ala
1105                1110                1115                1120
Ser Ser Asn Asp Asn Gly Glu Gln Val Asp His Thr Ala Ser Leu Pro
                1125                1130                1135    
Leu Pro Thr Pro Ala Thr Val Tyr Asn Ala Thr Ser Glu Glu Thr Ser
            1140                1145                1150        
Asn Asn Cys Pro Val Lys Asp Ala Thr Ala Ser Glu Lys Asn Glu Pro
        1155                1160                1165            
Glu Val Gln Trp Thr Ala Ser Thr Ser Val Glu Gln Val Arg Glu Arg
    1170                1175                1180                
Ser Tyr Gln Arg Ala Leu Leu Leu Ser Asp His Arg Lys Asp Lys Asp
1185                1190                1195                1200
Ser Gly Gly Glu Ser Pro Cys Val Ser Cys Ser Pro Ser His Val Gln
                1205                1210                1215    
Ser Ser Pro Ser Ser His Ser Asn His Ile Pro Gln Leu Gln Ala Lys
            1220                1225                1230        
Gly Pro Val Pro Ser Phe Ser Glu Leu Met Glu Asp Pro Asp Pro Glu
        1235                1240                1245            
Asn Pro Glu Pro Thr Thr Thr Asn Glu Cys Pro Ser Pro Asp Thr Ser
    1250                1255                1260                
Gln Asn Thr Cys Lys Ser Pro Pro Lys Met Ser Lys Pro Gly Ser Pro
1265                1270                1275                1280
Gly Ser Val Ile Pro Ala Gln Ala His Gly Lys Ile Phe Thr Lys Pro
                1285                1290                1295    
Asp Pro Gln Trp Asp Ser Thr Val Ser Ala Ser Glu Ala Glu Asn Gly
            1300                1305                1310        
Val His Leu Lys Thr Glu Leu Gln Gln Lys Gln Leu Ser Asn Asn Asn
        1315                1320                1325            
Gln Ala Leu Ser Lys Asn His Pro Pro Gln Thr His Val Arg Asn Ser
    1330                1335                1340                
Ser Glu Gln Leu Ser Gln Lys Leu Pro Ser Val Pro Thr Lys Leu His
1345                1350                1355                1360
Cys Pro Pro Ser Pro His Leu Glu Asn Pro Pro Lys Ser Ser Thr Pro
                1365                1370                1375    
His Thr Pro Val Gln His Gly Tyr Leu Ser Pro Lys Pro Pro Ser Gln
            1380                1385                1390        
Gln Leu Gly Ser Pro Tyr Arg Pro His His Ser Gln Ser Pro Gln Val
        1395                1400                1405            
Gly Thr Pro Gln Arg Glu Pro Gln Arg Asn Phe Tyr Pro Ala Ala Gln
    1410                1415                1420                
Asn Leu Pro Ala Asn Thr Gln Gln Ala Thr Ser Gly Thr Leu Phe Thr
1425                1430                1435                1440
Gln Thr Pro Ser Gly Gln Ser Ser Ala Thr Tyr Ser Gln Phe Asn Gln
                1445                1450                1455    
Gln Ser Leu Asn Ser Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro
            1460                1465                1470        
Ser Ser Ser Tyr Tyr Gln Asn Gln Gln Pro Ser Ala Asn Phe Gln Asn
        1475                1480                1485            
Tyr Asn Gln Leu Lys Gly Ser Leu Ser Gln Gln Thr Val Phe Thr Ser
    1490                1495                1500                
Gly Pro Asn Gln Ala Leu Pro Gly Thr Thr Ser Gln Gln Thr Val Pro
1505                1510                1515                1520
Gly His His Val Thr Pro Gly His Phe Leu Pro Ser Gln Asn Pro Thr
                1525                1530                1535    
Ile His His Gln Thr Ala Ala Ala Val Val Pro Pro Pro Pro Pro Pro
            1540                1545                1550        
Pro Pro Ala Pro Gly Pro His Leu Val Gln Gln Pro Asn Ser His Gln
        1555                1560                1565            
Gln His Ser Val Ala His Val Val Gly Pro Val His Ala Val Thr Pro
    1570                1575                1580                
Gly Ser His Ile His Ser Gln Thr Ala Gly His His Leu Pro Pro Pro
1585                1590                1595                1600
Pro Pro Pro Pro Gly Pro Ala Pro His His His Pro Pro Pro His Pro
                1605                1610                1615    
Ser Thr Gly Leu Gln Gly Leu Gln Ala Gln His Gln His Val Val Asn
            1620                1625                1630        
Ser Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Val Leu Ala
        1635                1640                1645            
Ser Gly His His Thr Thr Ser Ala Gln Ala Leu His His Pro Pro His
    1650                1655                1660                
Gln Gly Pro Pro Leu Phe Pro Ser Ser Ala His Pro Thr Val Pro Pro
1665                1670                1675                1680
Tyr Pro Ser Gln Ala Thr His His Thr Thr Leu Gly Pro Gly Pro Gln
                1685                1690                1695    
His Gln Pro Ser Gly Thr Gly Pro His Cys Pro Leu Pro Val Thr Gly
            1700                1705                1710        
Pro His Leu Gln Pro Gln Gly Pro Asn Ser Ile Pro Thr Pro Thr Ala
        1715                1720                1725            
Ser Gly Phe Cys Pro His Pro Gly Ser Val Ala Leu Pro His Gly Val
    1730                1735                1740                
Gln Gly Pro Gln Gln Ala Ser Pro Val Pro Gly Gln Ile Pro Ile His
1745                1750                1755                1760
Arg Ala Gln Val Pro Pro Thr Phe Gln Asn Asn Tyr His Gly Ser Gly
                1765                1770                1775    
Trp His
        


<210> 7578
<211> 443
<212> PRT
<213> Homo sapiens

<400> 7578
Ala Ser Pro Pro Pro Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile
 1               5                  10                  15      
Phe Thr Thr Pro Asn Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser
            20                  25                  30          
Thr Ser Glu Asp Gly Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys
        35                  40                  45              
Gly Phe Thr His Asp Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser
    50                  55                  60                  
Val Trp Gln His Ile Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro
65                  70                  75                  80  
Asp Thr Tyr Leu Cys Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu
                85                  90                  95      
Arg Ala Val Leu Leu Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly
            100                 105                 110         
Asp Thr Ser Ala Thr Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr
        115                 120                 125             
Thr Ala Phe Gln His Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg
    130                 135                 140                 
Val Ser Lys Val Asn Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu
145                 150                 155                 160 
Gln His Ile Ser Lys Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys
                165                 170                 175     
Ser Ser Arg Val Lys Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp
            180                 185                 190         
Gly Ser Asn Phe Gly Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg
        195                 200                 205             
Tyr Glu Glu Ala Asn Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu
    210                 215                 220                 
Ala Gln Arg Ile Ala Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu
225                 230                 235                 240 
Met Asn Lys Ser Asp Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro
                245                 250                 255     
Val Glu Ser His Ile Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys
            260                 265                 270         
Asp Leu Pro Pro Asp Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met
        275                 280                 285             
Leu Arg Glu Gln Phe Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr
    290                 295                 300                 
Pro Phe Val Leu Phe Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val
305                 310                 315                 320 
Asp Ala Arg Thr Phe Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys
                325                 330                 335     
Thr Pro Asn Ala Glu Val Arg His Glu Ile Gln Asp Gly Thr Ile His
            340                 345                 350         
Leu Tyr Ile Tyr Ser Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr
        355                 360                 365             
Ile Ala Phe Asp Phe Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys
    370                 375                 380                 
Ala Cys Leu Lys Glu Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser
385                 390                 395                 400 
Glu Ser Met Glu Asn Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys
                405                 410                 415     
Gly Lys Thr Lys Ile Phe Gln Lys Lys Lys Ile His Lys Ile Arg Ile
            420                 425                 430         
Leu Leu Trp Ile Val Lys Glu Arg Pro Thr Lys
        435                 440             


<210> 7579
<211> 453
<212> PRT
<213> Homo sapiens

<400> 7579
Met Val Leu Val Leu Ser Asp Thr Ser Ala Ser Pro Leu Leu Ser Val
 1               5                  10                  15      
Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn Phe Asp
            20                  25                  30          
Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly Ser Tyr
        35                  40                  45              
Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp Asp Gly
    50                  55                  60                  
Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile Asp Cys
65                  70                  75                  80  
Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys Glu Arg
                85                  90                  95      
Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu Gln Arg
            100                 105                 110         
Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr Glu Ser
        115                 120                 125             
Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His Thr Pro
    130                 135                 140                 
Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn Asp Lys
145                 150                 155                 160 
Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys Cys Lys
                165                 170                 175     
Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys Gly Ser
            180                 185                 190         
Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly Trp Glu
        195                 200                 205             
Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn Asn Asn
    210                 215                 220                 
Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala Leu Arg
225                 230                 235                 240 
Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp Leu Asn
                245                 250                 255     
Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile Gln Lys
            260                 265                 270         
Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp Ala Leu
        275                 280                 285             
Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe Glu Ala
    290                 295                 300                 
Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe Tyr Ser
305                 310                 315                 320 
Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe Gly Asn
                325                 330                 335     
Glu Ala Arg Phe Ile Arg Arg Ser Arg Thr Pro Asn Ala Glu Val Arg
            340                 345                 350         
His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser Ile His
        355                 360                 365             
Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe Asp Tyr
    370                 375                 380                 
Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu Asn Pro
385                 390                 395                 400 
Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn Ile Asn
                405                 410                 415     
Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Thr Lys Ile Phe
            420                 425                 430         
Gln Lys Lys Lys Ile His Lys Ile Arg Ile Leu Leu Arg Ile Val Lys
        435                 440                 445             
Glu Arg Pro Thr Lys
    450             


<210> 7580
<211> 1858
<212> PRT
<213> Homo sapiens

<400> 7580
Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr
 1               5                  10                  15      
Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro
            20                  25                  30          
Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser
        35                  40                  45              
Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His
    50                  55                  60                  
Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro
65                  70                  75                  80  
Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn
                85                  90                  95      
Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly
            100                 105                 110         
Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp
        115                 120                 125             
Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile
    130                 135                 140                 
Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys
145                 150                 155                 160 
Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu
                165                 170                 175     
Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr
            180                 185                 190         
Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His
        195                 200                 205             
Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn
    210                 215                 220                 
Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys
225                 230                 235                 240 
Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys
                245                 250                 255     
Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly
            260                 265                 270         
Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn
        275                 280                 285             
Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala
    290                 295                 300                 
Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp
305                 310                 315                 320 
Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile
                325                 330                 335     
Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp
            340                 345                 350         
Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe
        355                 360                 365             
Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe
    370                 375                 380                 
Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe
385                 390                 395                 400 
Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu
                405                 410                 415     
Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser
            420                 425                 430         
Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe
        435                 440                 445             
Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu
    450                 455                 460                 
Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn
465                 470                 475                 480 
Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys
                485                 490                 495     
Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp
            500                 505                 510         
Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg
        515                 520                 525             
Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp
    530                 535                 540                 
Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu
545                 550                 555                 560 
Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg
                565                 570                 575     
Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu
            580                 585                 590         
Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala
        595                 600                 605             
Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp
    610                 615                 620                 
Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro
625                 630                 635                 640 
Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg
                645                 650                 655     
Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser
            660                 665                 670         
Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser
        675                 680                 685             
Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr
    690                 695                 700                 
Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu
705                 710                 715                 720 
Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn
                725                 730                 735     
Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly
            740                 745                 750         
Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala
        755                 760                 765             
Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr
    770                 775                 780                 
Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu
785                 790                 795                 800 
Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys
                805                 810                 815     
Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu
            820                 825                 830         
His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val
        835                 840                 845             
Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu
    850                 855                 860                 
Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu
865                 870                 875                 880 
Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala
                885                 890                 895     
Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr
            900                 905                 910         
Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys
        915                 920                 925             
Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn
    930                 935                 940                 
Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile
945                 950                 955                 960 
Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met
                965                 970                 975     
Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu
            980                 985                 990         
Gln Glu Ile Lys Thr Ile Gly Tyr Thr Ser Pro Arg Ser Arg Thr Glu
        995                 1000                1005            
Val Asn Arg Gln Cys Pro Gly Glu Lys Glu Pro Val Ser Asp Leu Gln
    1010                1015                1020                
Leu Gly Leu Asp Ala Val Glu Pro Thr Ala Leu His Lys Thr Leu Glu
1025                1030                1035                1040
Thr Pro Ala His Asp Arg Ala Glu Pro Asn Ser Gln Leu Asp Ser Thr
                1045                1050                1055    
His Ser Gly Arg Gly Thr Met Tyr Ser Ser Trp Val Lys Ser Pro Asp
            1060                1065                1070        
Arg Thr Gly Val Asn Phe Ser Val Asn Ser Asn Leu Arg Asp Leu Thr
        1075                1080                1085            
Pro Ser His Gln Leu Glu Val Gly Gly Gly Phe Arg Ile Ser Glu Ser
    1090                1095                1100                
Lys Cys Leu Met Gln Asp Asp Thr Arg Gly Met Phe Met Glu Thr Thr
1105                1110                1115                1120
Val Phe Cys Thr Ser Glu Asp Gly Leu Val Ser Gly Phe Gly Arg Thr
                1125                1130                1135    
Val Asn Asp Asn Leu Ile Asp Gly Asn Cys Thr Pro Gln Asn Pro Pro
            1140                1145                1150        
Gln Lys Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg Gln Arg Glu
        1155                1160                1165            
Ala Arg Lys Ser Gly Ser Lys Thr Glu Asn Phe Pro Leu Ile Ser Val
    1170                1175                1180                
Ser Pro His Ala Ser Gly Ser Leu Ser Asn Asn Gly Asp Gly Cys Ala
1185                1190                1195                1200
Ser Ser Asn Asp Asn Gly Glu Gln Val Asp His Thr Ala Ser Leu Pro
                1205                1210                1215    
Leu Pro Thr Pro Ala Thr Val Tyr Asn Ala Thr Ser Glu Glu Thr Ser
            1220                1225                1230        
Asn Asn Cys Pro Val Lys Asp Ala Thr Ala Ser Glu Lys Asn Glu Pro
        1235                1240                1245            
Glu Val Gln Trp Thr Ala Ser Thr Ser Val Glu Gln Val Arg Glu Arg
    1250                1255                1260                
Ser Tyr Gln Arg Ala Leu Leu Leu Ser Asp His Arg Lys Asp Lys Asp
1265                1270                1275                1280
Ser Gly Gly Glu Ser Pro Cys Val Ser Cys Ser Pro Ser His Val Gln
                1285                1290                1295    
Ser Ser Pro Ser Ser His Ser Asn His Ile Pro Gln Leu Gln Ala Lys
            1300                1305                1310        
Gly Pro Val Pro Ser Phe Ser Glu Leu Met Glu Asp Pro Asp Pro Glu
        1315                1320                1325            
Asn Pro Glu Pro Thr Thr Thr Asn Glu Cys Pro Ser Pro Asp Thr Ser
    1330                1335                1340                
Gln Asn Thr Cys Lys Ser Pro Pro Lys Met Ser Lys Pro Gly Ser Pro
1345                1350                1355                1360
Gly Ser Val Ile Pro Ala Gln Ala His Gly Lys Ile Phe Thr Lys Pro
                1365                1370                1375    
Asp Pro Gln Trp Asp Ser Thr Val Ser Ala Ser Glu Ala Glu Asn Gly
            1380                1385                1390        
Val His Leu Lys Thr Glu Leu Gln Gln Lys Gln Leu Ser Asn Asn Asn
        1395                1400                1405            
Gln Ala Leu Ser Lys Asn His Pro Pro Gln Thr His Val Arg Asn Ser
    1410                1415                1420                
Ser Glu Gln Leu Ser Gln Lys Leu Pro Ser Val Pro Thr Lys Leu His
1425                1430                1435                1440
Cys Pro Pro Ser Pro His Leu Glu Asn Pro Pro Lys Ser Ser Thr Pro
                1445                1450                1455    
His Thr Pro Val Gln His Gly Tyr Leu Ser Pro Lys Pro Pro Ser Gln
            1460                1465                1470        
Gln Leu Gly Ser Pro Tyr Arg Pro His His Ser Gln Ser Pro Gln Val
        1475                1480                1485            
Gly Thr Pro Gln Arg Glu Pro Gln Arg Asn Phe Tyr Pro Ala Ala Gln
    1490                1495                1500                
Asn Leu Pro Ala Asn Thr Gln Gln Ala Thr Ser Gly Thr Leu Phe Thr
1505                1510                1515                1520
Gln Thr Pro Ser Gly Gln Ser Ser Ala Thr Tyr Ser Gln Phe Asn Gln
                1525                1530                1535    
Gln Ser Leu Asn Ser Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro
            1540                1545                1550        
Ser Ser Ser Tyr Tyr Gln Asn Gln Gln Pro Ser Ala Asn Phe Gln Asn
        1555                1560                1565            
Tyr Asn Gln Leu Lys Gly Ser Leu Ser Gln Gln Thr Val Phe Thr Ser
    1570                1575                1580                
Gly Pro Asn Gln Ala Leu Pro Gly Thr Thr Ser Gln Gln Thr Val Pro
1585                1590                1595                1600
Gly His His Val Thr Pro Gly His Phe Leu Pro Ser Gln Asn Pro Thr
                1605                1610                1615    
Ile His His Gln Thr Ala Ala Ala Val Val Pro Pro Pro Pro Pro Pro
            1620                1625                1630        
Pro Pro Ala Pro Gly Pro His Leu Val Gln Gln Pro Asn Ser His Gln
        1635                1640                1645            
Gln His Ser Val Ala His Val Val Gly Pro Val His Ala Val Thr Pro
    1650                1655                1660                
Gly Ser His Ile His Ser Gln Thr Ala Gly His His Leu Pro Pro Pro
1665                1670                1675                1680
Pro Pro Pro Pro Gly Pro Ala Pro His His His Pro Pro Pro His Pro
                1685                1690                1695    
Ser Thr Gly Leu Gln Gly Leu Gln Ala Gln His Gln His Val Val Asn
            1700                1705                1710        
Ser Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Val Leu Ala
        1715                1720                1725            
Ser Gly His His Thr Thr Ser Ala Gln Ala Leu His His Pro Pro His
    1730                1735                1740                
Gln Gly Pro Pro Leu Phe Pro Ser Ser Ala His Pro Thr Val Pro Pro
1745                1750                1755                1760
Tyr Pro Ser Gln Ala Thr His His Thr Thr Leu Gly Pro Gly Pro Gln
                1765                1770                1775    
His Gln Pro Ser Gly Thr Gly Pro His Cys Pro Leu Pro Val Thr Gly
            1780                1785                1790        
Pro His Leu Gln Pro Gln Gly Pro Asn Ser Ile Pro Thr Pro Thr Ala
        1795                1800                1805            
Ser Gly Phe Cys Pro His Pro Gly Ser Val Ala Leu Pro His Gly Val
    1810                1815                1820                
Gln Gly Pro Gln Gln Ala Ser Pro Val Pro Gly Gln Ile Pro Ile His
1825                1830                1835                1840
Arg Ala Gln Val Pro Pro Thr Phe Gln Asn Asn Tyr His Gly Ser Gly
                1845                1850                1855    
Trp His
        


<210> 7581
<211> 1858
<212> PRT
<213> Homo sapiens

<400> 7581
Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr
 1               5                  10                  15      
Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro
            20                  25                  30          
Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser
        35                  40                  45              
Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His
    50                  55                  60                  
Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro
65                  70                  75                  80  
Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn
                85                  90                  95      
Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly
            100                 105                 110         
Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp
        115                 120                 125             
Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile
    130                 135                 140                 
Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys
145                 150                 155                 160 
Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu
                165                 170                 175     
Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr
            180                 185                 190         
Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His
        195                 200                 205             
Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn
    210                 215                 220                 
Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys
225                 230                 235                 240 
Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys
                245                 250                 255     
Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly
            260                 265                 270         
Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn
        275                 280                 285             
Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala
    290                 295                 300                 
Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp
305                 310                 315                 320 
Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile
                325                 330                 335     
Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp
            340                 345                 350         
Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe
        355                 360                 365             
Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe
    370                 375                 380                 
Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe
385                 390                 395                 400 
Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu
                405                 410                 415     
Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser
            420                 425                 430         
Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe
        435                 440                 445             
Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu
    450                 455                 460                 
Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn
465                 470                 475                 480 
Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Glu
                485                 490                 495     
Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp
            500                 505                 510         
Cys Glu Gly Ala Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg
        515                 520                 525             
Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp
    530                 535                 540                 
Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu
545                 550                 555                 560 
Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg
                565                 570                 575     
Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu
            580                 585                 590         
Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala
        595                 600                 605             
Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp
    610                 615                 620                 
Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro
625                 630                 635                 640 
Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg
                645                 650                 655     
Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser
            660                 665                 670         
Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser
        675                 680                 685             
Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr
    690                 695                 700                 
Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu
705                 710                 715                 720 
Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn
                725                 730                 735     
Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly
            740                 745                 750         
Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala
        755                 760                 765             
Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr
    770                 775                 780                 
Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu
785                 790                 795                 800 
Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys
                805                 810                 815     
Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu
            820                 825                 830         
His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val
        835                 840                 845             
Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu
    850                 855                 860                 
Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu
865                 870                 875                 880 
Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala
                885                 890                 895     
Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr
            900                 905                 910         
Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys
        915                 920                 925             
Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn
    930                 935                 940                 
Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile
945                 950                 955                 960 
Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met
                965                 970                 975     
Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu
            980                 985                 990         
Gln Glu Ile Lys Thr Ile Gly Tyr Thr Ser Pro Arg Ser Arg Thr Glu
        995                 1000                1005            
Val Asn Arg Gln Cys Pro Gly Glu Lys Glu Pro Ala Ser Asp Leu Gln
    1010                1015                1020                
Leu Gly Leu Asp Ala Val Glu Pro Thr Ala Leu His Lys Thr Leu Glu
1025                1030                1035                1040
Thr Pro Ala His Asp Arg Ala Glu Pro Asn Ser Gln Leu Asp Ser Thr
                1045                1050                1055    
His Ser Gly Arg Gly Thr Met Tyr Ser Ser Trp Val Lys Ser Pro Asp
            1060                1065                1070        
Ser Thr Gly Val Asn Phe Ser Val Asn Ser Asn Leu Arg Asp Leu Thr
        1075                1080                1085            
Pro Pro His Gln Leu Glu Val Gly Gly Gly Ser Arg Ile Ser Glu Ser
    1090                1095                1100                
Lys Cys Leu Met Gln Asp Asp Thr Arg Gly Met Phe Met Glu Thr Thr
1105                1110                1115                1120
Val Phe Cys Thr Ser Glu Asp Gly Leu Val Ser Gly Phe Gly Arg Thr
                1125                1130                1135    
Val Asn Asp Asn Leu Ile Asp Gly Asn Cys Thr Pro Gln Asn Pro Pro
            1140                1145                1150        
Gln Lys Lys Lys Val Ser Leu Leu Glu Tyr Arg Lys Arg Gln Arg Lys
        1155                1160                1165            
Ala Arg Lys Ser Gly Ser Lys Thr Glu Asn Phe Pro Leu Ile Ser Val
    1170                1175                1180                
Ser Pro His Ala Ser Gly Ser Leu Ser Asn Asn Gly Asp Gly Cys Ala
1185                1190                1195                1200
Ser Ser Asn Asp Asn Gly Glu Gln Val Asp His Thr Ala Ser Leu Pro
                1205                1210                1215    
Leu Pro Thr Pro Ala Thr Val Tyr Asn Ala Thr Ser Glu Glu Thr Ser
            1220                1225                1230        
Asn Asn Cys Pro Val Lys Asp Ala Thr Ala Ser Glu Lys Asn Glu Pro
        1235                1240                1245            
Glu Val Gln Trp Thr Ala Ser Thr Ser Val Glu Gln Val Arg Glu Arg
    1250                1255                1260                
Ser Tyr Gln Arg Ala Leu Leu Leu Ser Asp His Arg Lys Asp Lys Asp
1265                1270                1275                1280
Ser Gly Gly Glu Ser Pro Cys Val Ser Cys Ser Pro Ser His Val Gln
                1285                1290                1295    
Ser Ser Pro Ser Ser His Ser Asn His Ile Pro Gln Leu Gln Ala Lys
            1300                1305                1310        
Gly Pro Val Pro Ser Phe Ser Glu Leu Met Glu Asp Pro Asp Pro Glu
        1315                1320                1325            
Asn Pro Glu Pro Thr Thr Thr Asn Glu Cys Pro Ser Pro Asp Thr Ser
    1330                1335                1340                
Gln Asn Thr Cys Lys Ser Pro Pro Lys Met Ser Lys Pro Gly Ser Pro
1345                1350                1355                1360
Gly Ser Val Ile Pro Ala Gln Ala His Gly Lys Ile Phe Thr Lys Pro
                1365                1370                1375    
Asp Pro Gln Trp Asp Ser Thr Val Ser Ala Ser Glu Ala Glu Asn Gly
            1380                1385                1390        
Val His Leu Lys Thr Glu Leu Gln Gln Lys Gln Leu Ser Asn Asn Asn
        1395                1400                1405            
Gln Ala Leu Ser Lys Asn His Pro Pro Gln Thr His Val Arg Asn Ser
    1410                1415                1420                
Ser Glu Gln Leu Ser Gln Lys Leu Pro Ser Val Pro Thr Lys Leu His
1425                1430                1435                1440
Cys Pro Pro Ser Pro His Leu Glu Asn Pro Pro Lys Ser Ser Thr Pro
                1445                1450                1455    
His Thr Pro Val Gln His Gly Tyr Leu Ser Pro Lys Pro Pro Ser Gln
            1460                1465                1470        
Gln Leu Gly Ser Pro Tyr Arg Pro His His Ser Gln Ser Pro Gln Val
        1475                1480                1485            
Gly Thr Pro Gln Arg Glu Pro Gln Arg Asn Phe Tyr Pro Ala Ala Gln
    1490                1495                1500                
Asn Leu Pro Ala Asn Thr Gln Gln Ala Thr Ser Gly Thr Leu Phe Thr
1505                1510                1515                1520
Gln Thr Pro Ser Gly Gln Ser Ser Ala Thr Tyr Ser Gln Phe Asn Gln
                1525                1530                1535    
Gln Ser Leu Asn Ser Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro
            1540                1545                1550        
Ser Ser Ser Tyr Tyr Gln Asn Gln Gln Pro Ser Ala Asn Phe Gln Asn
        1555                1560                1565            
Tyr Asn Gln Leu Lys Gly Ser Leu Ser Gln Gln Thr Val Phe Thr Ser
    1570                1575                1580                
Gly Pro Asn Gln Ala Leu Pro Gly Thr Thr Ser Gln Gln Thr Val Pro
1585                1590                1595                1600
Gly His His Val Thr Pro Gly His Phe Leu Pro Ser Gln Asn Pro Thr
                1605                1610                1615    
Ile His His Gln Thr Ala Ala Ala Val Val Pro Pro Pro Pro Pro Pro
            1620                1625                1630        
Pro Pro Ala Pro Gly Pro His Leu Val Gln Gln Pro Asn Ser His Gln
        1635                1640                1645            
Gln His Ser Val Ala His Val Val Gly Pro Val His Ala Val Thr Pro
    1650                1655                1660                
Gly Ser His Ile His Ser Gln Thr Ala Gly His His Leu Pro Pro Pro
1665                1670                1675                1680
Pro Pro Pro Pro Gly Pro Ala Pro His His His Pro Pro Pro His Pro
                1685                1690                1695    
Ser Thr Gly Leu Gln Gly Leu Gln Ala Gln His Gln His Val Val Asn
            1700                1705                1710        
Ser Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Val Leu Ala
        1715                1720                1725            
Ser Gly His His Thr Thr Ser Ala Gln Ala Leu His His Pro Pro His
    1730                1735                1740                
Gln Gly Pro Pro Leu Phe Pro Ser Ser Ala His Pro Thr Val Pro Pro
1745                1750                1755                1760
Tyr Pro Ser Gln Ala Thr His His Thr Thr Leu Gly Pro Gly Pro Gln
                1765                1770                1775    
His Gln Pro Ser Gly Thr Gly Pro His Cys Pro Leu Pro Val Thr Gly
            1780                1785                1790        
Pro His Leu Gln Pro Gln Gly Pro Asn Ser Ile Pro Thr Pro Thr Ala
        1795                1800                1805            
Ser Gly Phe Cys Pro His Pro Gly Ser Val Ala Leu Pro His Gly Val
    1810                1815                1820                
Gln Gly Pro Gln Gln Ala Ser Pro Val Pro Gly Gln Ile Pro Ile His
1825                1830                1835                1840
Arg Ala Gln Val Pro Pro Thr Phe Gln Asn Asn Tyr His Gly Ser Gly
                1845                1850                1855    
Trp His
        


<210> 7582
<211> 592
<212> PRT
<213> Homo sapiens

<400> 7582
Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr
 1               5                  10                  15      
Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro
            20                  25                  30          
Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser
        35                  40                  45              
Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His
    50                  55                  60                  
Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro
65                  70                  75                  80  
Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn
                85                  90                  95      
Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly
            100                 105                 110         
Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp
        115                 120                 125             
Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile
    130                 135                 140                 
Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys
145                 150                 155                 160 
Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu
                165                 170                 175     
Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr
            180                 185                 190         
Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His
        195                 200                 205             
Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn
    210                 215                 220                 
Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys
225                 230                 235                 240 
Cys Lys Lys Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser
                245                 250                 255     
Asn Phe Gly Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu
            260                 265                 270         
Glu Ala Asn Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln
        275                 280                 285             
Arg Ile Ala Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn
    290                 295                 300                 
Lys Ser Asp Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu
305                 310                 315                 320 
Ser His Ile Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu
                325                 330                 335     
Pro Pro Asp Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg
            340                 345                 350         
Glu Gln Phe Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe
        355                 360                 365             
Val Leu Phe Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala
    370                 375                 380                 
Arg Thr Phe Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro
385                 390                 395                 400 
Asn Ala Glu Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr
                405                 410                 415     
Ile Tyr Ser Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala
            420                 425                 430         
Phe Asp Phe Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys
        435                 440                 445             
Leu Lys Glu Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser
    450                 455                 460                 
Met Glu Asn Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys
465                 470                 475                 480 
Lys Asp Lys Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile
                485                 490                 495     
Thr Leu Asp Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr
            500                 505                 510         
Lys Gln Arg Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln
        515                 520                 525             
Glu Pro Asp Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn
    530                 535                 540                 
Glu Val Glu Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys
545                 550                 555                 560 
Met Asn Trp Thr Val Asp Gly Cys Gly Ser Trp Phe Trp Phe Arg Ala
                565                 570                 575     
Glu Ala Ser Val Lys Ala Leu Gly Leu Thr Leu Asn Val Leu Phe Gly
            580                 585                 590         


<210> 7583
<211> 727
<212> PRT
<213> Homo sapiens

<400> 7583
Met Asn Gly Glu Ala Asp Cys Pro Thr Asp Leu Glu Met Ala Ala Pro
 1               5                  10                  15      
Lys Gly Gln Asp Arg Trp Ser Gln Glu Asp Met Leu Thr Leu Leu Glu
            20                  25                  30          
Cys Met Lys Asn Asn Leu Pro Ser Asn Asp Ser Ser Lys Phe Lys Thr
        35                  40                  45              
Thr Glu Ser His Met Asp Trp Glu Lys Val Ala Phe Lys Asp Phe Ser
    50                  55                  60                  
Gly Asp Met Cys Lys Leu Lys Trp Val Glu Ile Ser Asn Glu Val Arg
65                  70                  75                  80  
Lys Phe Arg Thr Leu Thr Glu Leu Ile Leu Asp Ala Gln Glu His Val
                85                  90                  95      
Lys Asn Pro Tyr Lys Gly Lys Lys Leu Lys Lys His Pro Asp Phe Pro
            100                 105                 110         
Lys Lys Pro Leu Thr Pro Tyr Phe Arg Phe Phe Met Glu Lys Arg Ala
        115                 120                 125             
Lys Tyr Ala Lys Leu His Pro Glu Met Ser Asn Leu Asp Leu Thr Lys
    130                 135                 140                 
Ile Leu Ser Lys Lys Tyr Lys Glu Leu Pro Glu Lys Lys Lys Met Lys
145                 150                 155                 160 
Tyr Ile Gln Asp Phe Gln Arg Glu Lys Gln Glu Phe Glu Arg Asn Leu
                165                 170                 175     
Ala Arg Phe Arg Glu Asp His Pro Asp Leu Ile Gln Asn Ala Lys Lys
            180                 185                 190         
Ser Asp Ile Pro Glu Lys Pro Lys Thr Pro Gln Gln Leu Trp Tyr Thr
        195                 200                 205             
His Glu Lys Lys Val Tyr Leu Lys Val Arg Pro Asp Glu Ile Met Arg
    210                 215                 220                 
Asp Tyr Ile Gln Lys His Pro Glu Leu Asn Ile Ser Glu Glu Gly Ile
225                 230                 235                 240 
Thr Lys Ser Thr Leu Thr Lys Ala Glu Arg Gln Leu Lys Asp Lys Phe
                245                 250                 255     
Asp Gly Arg Pro Thr Lys Pro Pro Pro Asn Ser Tyr Ser Leu Tyr Cys
            260                 265                 270         
Ala Glu Leu Met Ala Asn Met Lys Asp Val Pro Ser Thr Glu Arg Met
        275                 280                 285             
Val Leu Cys Ser Gln Gln Trp Lys Leu Leu Ser Gln Lys Glu Lys Asp
    290                 295                 300                 
Ala Tyr His Lys Lys Cys Asp Gln Lys Lys Lys Asp Tyr Glu Val Glu
305                 310                 315                 320 
Leu Leu Arg Phe Leu Glu Ser Leu Pro Glu Glu Glu Gln Gln Arg Val
                325                 330                 335     
Leu Gly Glu Glu Lys Met Leu Asn Ile Asn Lys Lys Gln Ala Thr Ser
            340                 345                 350         
Pro Ala Ser Lys Lys Pro Ala Gln Glu Gly Gly Lys Gly Gly Ser Glu
        355                 360                 365             
Lys Pro Lys Arg Pro Val Ser Ala Met Phe Ile Phe Ser Glu Glu Lys
    370                 375                 380                 
Arg Arg Gln Leu Gln Glu Glu Arg Pro Glu Leu Ser Glu Ser Glu Leu
385                 390                 395                 400 
Thr Arg Leu Leu Ala Arg Met Trp Asn Asp Leu Ser Glu Lys Lys Lys
                405                 410                 415     
Ala Lys Tyr Lys Ala Arg Glu Ala Ala Leu Lys Ala Gln Ser Glu Arg
            420                 425                 430         
Lys Pro Gly Gly Glu Arg Glu Glu Arg Gly Lys Leu Pro Glu Ser Pro
        435                 440                 445             
Lys Arg Ala Glu Glu Ile Trp Gln Gln Ser Val Ile Gly Asp Tyr Leu
    450                 455                 460                 
Ala Arg Phe Lys Asn Asp Arg Val Lys Ala Leu Lys Ala Met Glu Met
465                 470                 475                 480 
Thr Trp Asn Asn Met Glu Lys Lys Glu Lys Leu Met Trp Ile Lys Lys
                485                 490                 495     
Ala Ala Glu Asp Gln Lys Arg Tyr Glu Arg Glu Leu Ser Glu Met Arg
            500                 505                 510         
Ala Pro Pro Ala Ala Thr Asn Ser Ser Lys Lys Met Lys Phe Gln Gly
        515                 520                 525             
Glu Pro Lys Lys Pro Pro Met Asn Gly Tyr Gln Lys Phe Ser Gln Glu
    530                 535                 540                 
Leu Leu Ser Asn Gly Glu Leu Asn His Leu Pro Leu Lys Glu Arg Met
545                 550                 555                 560 
Val Glu Ile Gly Ser Arg Trp Gln Arg Ile Ser Gln Ser Gln Lys Glu
                565                 570                 575     
His Tyr Lys Lys Leu Ala Glu Glu Gln Gln Lys Gln Tyr Lys Val His
            580                 585                 590         
Leu Asp Leu Trp Val Lys Ser Leu Ser Pro Gln Asp Arg Ala Ala Tyr
        595                 600                 605             
Lys Glu Tyr Ile Ser Asn Lys Arg Lys Ser Met Thr Lys Leu Arg Gly
    610                 615                 620                 
Pro Asn Pro Lys Ser Ser Arg Thr Thr Leu Gln Ser Lys Ser Glu Ser
625                 630                 635                 640 
Glu Glu Asp Asp Glu Glu Asp Glu Asp Asp Glu Asp Glu Asp Glu Glu
                645                 650                 655     
Glu Glu Asp Asp Glu Asn Gly Asp Ser Ser Glu Asp Gly Gly Asp Ser
            660                 665                 670         
Ser Glu Ser Ser Ser Glu Asp Glu Ser Glu Asp Gly Asp Glu Asn Glu
        675                 680                 685             
Glu Asp Asp Glu Asp Glu Asp Asp Asp Glu Asp Asp Asp Glu Asp Glu
    690                 695                 700                 
Asp Asn Glu Ser Glu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Asp
705                 710                 715                 720 
Ser Ser Asp Ser Asp Ser Asn
                725         


<210> 7584
<211> 654
<212> PRT
<213> Homo sapiens

<400> 7584
Met Lys Tyr Ile Gln Asp Phe Gln Arg Glu Lys Gln Glu Phe Glu Arg
 1               5                  10                  15      
Asn Leu Ala Arg Phe Arg Glu Asp His Pro Asp Leu Ile Gln Asn Ala
            20                  25                  30          
Lys Lys Ser Asp Ile Pro Glu Lys Pro Lys Thr Pro Gln Gln Leu Trp
        35                  40                  45              
Tyr Thr His Glu Lys Lys Val Tyr Leu Lys Val Arg Pro Asp Ala Thr
    50                  55                  60                  
Thr Lys Glu Val Lys Asp Ser Leu Gly Lys Gln Trp Ser Gln Leu Ser
65                  70                  75                  80  
Asp Lys Lys Arg Leu Lys Trp Ile His Lys Ala Leu Glu Gln Arg Lys
                85                  90                  95      
Glu Tyr Glu Glu Ile Met Arg Asp Tyr Ile Gln Lys His Pro Glu Leu
            100                 105                 110         
Asn Ile Ser Glu Glu Gly Ile Thr Lys Ser Thr Leu Thr Lys Ala Glu
        115                 120                 125             
Arg Gln Leu Lys Asp Lys Phe Asp Gly Arg Pro Thr Lys Pro Pro Pro
    130                 135                 140                 
Asn Ser Tyr Ser Leu Tyr Cys Ala Glu Leu Met Ala Asn Met Lys Asp
145                 150                 155                 160 
Val Pro Ser Thr Glu Arg Met Val Leu Cys Ser Gln Gln Trp Lys Leu
                165                 170                 175     
Leu Ser Gln Lys Glu Lys Asp Ala Tyr His Lys Lys Cys Asp Gln Lys
            180                 185                 190         
Lys Lys Asp Tyr Glu Val Glu Leu Leu Arg Phe Leu Glu Ser Leu Pro
        195                 200                 205             
Glu Glu Glu Gln Gln Arg Val Leu Gly Glu Glu Lys Met Leu Asn Ile
    210                 215                 220                 
Asn Lys Lys Gln Ala Thr Ser Pro Ala Ser Lys Lys Pro Ala Gln Glu
225                 230                 235                 240 
Gly Gly Lys Gly Gly Ser Glu Lys Pro Lys Arg Pro Val Ser Ala Met
                245                 250                 255     
Phe Ile Phe Ser Glu Glu Lys Arg Arg Gln Leu Gln Glu Glu Arg Pro
            260                 265                 270         
Glu Leu Ser Glu Ser Glu Leu Thr Arg Leu Leu Ala Arg Met Trp Asn
        275                 280                 285             
Asp Leu Ser Glu Lys Lys Lys Ala Lys Tyr Lys Ala Arg Glu Ala Ala
    290                 295                 300                 
Leu Lys Ala Gln Ser Glu Arg Lys Pro Gly Gly Glu Arg Glu Glu Arg
305                 310                 315                 320 
Gly Lys Leu Pro Glu Ser Pro Lys Arg Ala Glu Glu Ile Trp Gln Gln
                325                 330                 335     
Ser Val Ile Gly Asp Tyr Leu Ala Arg Phe Lys Asn Asp Arg Val Lys
            340                 345                 350         
Ala Leu Lys Ala Met Glu Met Thr Trp Asn Asn Met Glu Lys Lys Glu
        355                 360                 365             
Lys Leu Met Trp Ile Lys Lys Ala Ala Glu Asp Gln Lys Arg Tyr Glu
    370                 375                 380                 
Arg Glu Leu Ser Glu Met Arg Ala Pro Pro Ala Ala Thr Asn Ser Ser
385                 390                 395                 400 
Lys Lys Met Lys Phe Gln Gly Glu Pro Lys Lys Pro Pro Met Asn Gly
                405                 410                 415     
Tyr Gln Lys Phe Ser Gln Glu Leu Leu Ser Asn Gly Glu Leu Asn His
            420                 425                 430         
Leu Pro Leu Lys Glu Arg Met Val Glu Ile Gly Ser Arg Trp Gln Arg
        435                 440                 445             
Ile Ser Gln Ser Gln Lys Glu His Tyr Lys Lys Leu Ala Glu Glu Gln
    450                 455                 460                 
Gln Lys Gln Tyr Lys Val His Leu Asp Leu Trp Val Lys Ser Leu Ser
465                 470                 475                 480 
Pro Gln Asp Arg Ala Ala Tyr Lys Glu Tyr Ile Ser Asn Lys Arg Lys
                485                 490                 495     
Ser Met Thr Lys Leu Arg Gly Pro Asn Pro Lys Ser Ser Arg Thr Thr
            500                 505                 510         
Leu Gln Ser Lys Ser Glu Ser Glu Glu Asp Asp Glu Glu Asp Glu Asp
        515                 520                 525             
Asp Glu Asp Glu Asp Glu Glu Glu Glu Asp Asp Glu Asn Gly Asp Ser
    530                 535                 540                 
Ser Glu Asp Gly Gly Asp Ser Ser Glu Ser Ser Ser Glu Asp Glu Ser
545                 550                 555                 560 
Glu Asp Gly Asp Glu Val Gly Gln Thr Gly His Ser Gly Arg Gly Gly
                565                 570                 575     
Glu Ser Cys Gln Glu Gly His Leu Val Thr Pro His Pro Phe Ser Pro
            580                 585                 590         
Pro Arg Met Lys Arg Met Thr Arg Thr Lys Thr Thr Thr Arg Met Thr
        595                 600                 605             
Met Arg Met Lys Ile Met Ser Pro Arg Ala Ala Ala Pro Ala Pro Pro
    610                 615                 620                 
Pro Gln Gly Thr Pro Gln Thr Leu Thr Pro Thr Glu Ala Gln Pro His
625                 630                 635                 640 
Pro Arg Ala Ala Arg Glu Ser Pro Gly Ala Pro Leu Pro Asn
                645                 650                 


<210> 7585
<211> 764
<212> PRT
<213> Homo sapiens

<400> 7585
Met Asn Gly Glu Ala Asp Cys Pro Thr Asp Leu Glu Met Ala Ala Pro
 1               5                  10                  15      
Lys Gly Gln Asp Arg Trp Ser Gln Glu Asp Met Leu Thr Leu Leu Glu
            20                  25                  30          
Cys Met Lys Asn Asn Leu Pro Ser Asn Asp Ser Ser Lys Phe Lys Thr
        35                  40                  45              
Thr Glu Ser His Met Asp Trp Glu Lys Val Ala Phe Lys Asp Phe Ser
    50                  55                  60                  
Gly Asp Met Cys Lys Leu Lys Trp Val Glu Ile Ser Asn Glu Val Arg
65                  70                  75                  80  
Lys Phe Arg Thr Leu Thr Glu Leu Ile Leu Asp Ala Gln Glu His Val
                85                  90                  95      
Lys Asn Pro Tyr Lys Gly Lys Lys Leu Lys Lys His Pro Asp Phe Pro
            100                 105                 110         
Lys Lys Pro Leu Thr Pro Tyr Phe Arg Phe Phe Met Glu Lys Arg Ala
        115                 120                 125             
Lys Tyr Ala Lys Leu His Pro Glu Met Ser Asn Leu Asp Leu Thr Lys
    130                 135                 140                 
Ile Leu Ser Lys Lys Tyr Lys Glu Leu Pro Glu Lys Lys Lys Met Lys
145                 150                 155                 160 
Tyr Ile Gln Asp Phe Gln Arg Glu Lys Gln Glu Phe Glu Arg Asn Leu
                165                 170                 175     
Ala Arg Phe Arg Glu Asp His Pro Asp Leu Ile Gln Asn Ala Lys Lys
            180                 185                 190         
Ser Asp Ile Pro Glu Lys Pro Lys Thr Pro Gln Gln Leu Trp Tyr Thr
        195                 200                 205             
His Glu Lys Lys Val Tyr Leu Lys Val Arg Pro Asp Ala Thr Thr Lys
    210                 215                 220                 
Glu Val Lys Asp Ser Leu Gly Lys Gln Trp Ser Gln Leu Ser Asp Lys
225                 230                 235                 240 
Lys Arg Leu Lys Trp Ile His Lys Ala Leu Glu Gln Arg Lys Glu Tyr
                245                 250                 255     
Glu Glu Ile Met Arg Asp Tyr Ile Gln Lys His Pro Glu Leu Asn Ile
            260                 265                 270         
Ser Glu Glu Gly Ile Thr Lys Ser Thr Leu Thr Lys Ala Glu Arg Gln
        275                 280                 285             
Leu Lys Asp Lys Phe Asp Gly Arg Pro Thr Lys Pro Pro Pro Asn Ser
    290                 295                 300                 
Tyr Ser Leu Tyr Cys Ala Glu Leu Met Ala Asn Met Lys Asp Val Pro
305                 310                 315                 320 
Ser Thr Glu Arg Met Val Leu Cys Ser Gln Gln Trp Lys Leu Leu Ser
                325                 330                 335     
Gln Lys Glu Lys Asp Ala Tyr His Lys Lys Cys Asp Gln Lys Lys Lys
            340                 345                 350         
Asp Tyr Glu Val Glu Leu Leu Arg Phe Leu Glu Ser Leu Pro Glu Glu
        355                 360                 365             
Glu Gln Gln Arg Val Leu Gly Glu Glu Lys Met Leu Asn Ile Asn Lys
    370                 375                 380                 
Lys Gln Ala Thr Ser Pro Ala Ser Lys Lys Pro Ala Gln Glu Gly Gly
385                 390                 395                 400 
Lys Gly Gly Ser Glu Lys Pro Lys Arg Pro Val Ser Ala Met Phe Ile
                405                 410                 415     
Phe Ser Glu Glu Lys Arg Arg Gln Leu Gln Glu Glu Arg Pro Glu Leu
            420                 425                 430         
Ser Glu Ser Glu Leu Thr Arg Leu Leu Ala Arg Met Trp Asn Asp Leu
        435                 440                 445             
Ser Glu Lys Lys Lys Ala Lys Tyr Lys Ala Arg Glu Ala Ala Leu Lys
    450                 455                 460                 
Ala Gln Ser Glu Arg Lys Pro Gly Gly Glu Arg Glu Glu Arg Gly Lys
465                 470                 475                 480 
Leu Pro Glu Ser Pro Lys Arg Ala Glu Glu Ile Trp Gln Gln Ser Val
                485                 490                 495     
Ile Gly Asp Tyr Leu Ala Arg Phe Lys Asn Asp Arg Val Lys Ala Leu
            500                 505                 510         
Lys Ala Met Glu Met Thr Trp Asn Asn Met Glu Lys Lys Glu Lys Leu
        515                 520                 525             
Met Trp Ile Lys Lys Ala Ala Glu Asp Gln Lys Arg Tyr Glu Arg Glu
    530                 535                 540                 
Leu Ser Glu Met Arg Ala Pro Pro Ala Ala Thr Asn Ser Ser Lys Lys
545                 550                 555                 560 
Met Lys Phe Gln Gly Glu Pro Lys Lys Pro Pro Met Asn Gly Tyr Gln
                565                 570                 575     
Lys Phe Ser Gln Glu Leu Leu Ser Asn Gly Glu Leu Asn His Leu Pro
            580                 585                 590         
Leu Lys Glu Arg Met Val Glu Ile Gly Ser Arg Trp Gln Arg Ile Ser
        595                 600                 605             
Gln Ser Gln Lys Glu His Tyr Lys Lys Leu Ala Glu Glu Gln Gln Lys
    610                 615                 620                 
Gln Tyr Lys Val His Leu Asp Leu Trp Val Lys Ser Leu Ser Pro Gln
625                 630                 635                 640 
Asp Arg Ala Ala Tyr Lys Glu Tyr Ile Ser Asn Lys Arg Lys Ser Met
                645                 650                 655     
Thr Lys Leu Arg Gly Pro Asn Pro Lys Ser Ser Arg Thr Thr Leu Gln
            660                 665                 670         
Ser Lys Ser Glu Ser Glu Glu Asp Asp Glu Glu Asp Glu Asp Asp Glu
        675                 680                 685             
Asp Glu Asp Glu Glu Glu Glu Asp Asp Glu Asn Gly Asp Ser Ser Glu
    690                 695                 700                 
Asp Gly Gly Asp Ser Ser Glu Ser Ser Ser Glu Asp Glu Ser Glu Asp
705                 710                 715                 720 
Gly Asp Glu Asn Glu Glu Asp Asp Glu Asp Glu Asp Asp Asp Glu Asp
                725                 730                 735     
Asp Asp Glu Asp Glu Asp Asn Glu Ser Glu Gly Ser Ser Ser Ser Ser
            740                 745                 750         
Ser Ser Ser Gly Asp Ser Ser Asp Ser Asp Ser Asn
        755                 760                 


<210> 7586
<211> 835
<212> PRT
<213> Homo sapiens

<400> 7586
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu
 1               5                  10                  15      
Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp
            20                  25                  30          
His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys
        35                  40                  45              
Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile
    50                  55                  60                  
Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala
65                  70                  75                  80  
Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser
                85                  90                  95      
Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys
            100                 105                 110         
Leu Ser Thr Ser Ser Arg Arg Ile Cys Pro Lys Gln Glu His Ile Ala
        115                 120                 125             
Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His
    130                 135                 140                 
Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln
145                 150                 155                 160 
Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys
                165                 170                 175     
Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr
            180                 185                 190         
His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr
        195                 200                 205             
Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln
    210                 215                 220                 
Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu
225                 230                 235                 240 
Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu
                245                 250                 255     
Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His
            260                 265                 270         
His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala
        275                 280                 285             
Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn
    290                 295                 300                 
Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg
305                 310                 315                 320 
Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro
                325                 330                 335     
Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro
            340                 345                 350         
Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro
        355                 360                 365             
Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys
    370                 375                 380                 
Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr
385                 390                 395                 400 
Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln
                405                 410                 415     
Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser
            420                 425                 430         
Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro
        435                 440                 445             
Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys
    450                 455                 460                 
Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro
465                 470                 475                 480 
Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu
                485                 490                 495     
Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp
            500                 505                 510         
Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser
        515                 520                 525             
Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro
    530                 535                 540                 
Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu
545                 550                 555                 560 
Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala
                565                 570                 575     
Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly
            580                 585                 590         
Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser
        595                 600                 605             
Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly
    610                 615                 620                 
Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys
625                 630                 635                 640 
Glu Phe Asp Leu Pro Pro Ala Thr Met Pro Asn Thr Glu Asn Val Tyr
                645                 650                 655     
Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro
            660                 665                 670         
Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser
        675                 680                 685             
Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly
    690                 695                 700                 
Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly
705                 710                 715                 720 
Ser Thr Pro His Ile Ser Gly Pro Gly Thr Gly Arg Pro Ser Ser Lys
                725                 730                 735     
Glu Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys
            740                 745                 750         
Asn Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg
        755                 760                 765             
Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys
    770                 775                 780                 
Leu Thr Arg His Met Lys Thr His Gly Gln Val Gly Lys Asp Val Tyr
785                 790                 795                 800 
Lys Cys Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Thr Leu Glu
                805                 810                 815     
Lys His Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile
            820                 825                 830         
Lys Thr Glu
        835 


<210> 7587
<211> 800
<212> PRT
<213> Homo sapiens

<400> 7587
Pro Gly Ser Pro Asp Val Asn Arg Ala Val Val Arg Pro Pro Pro Pro
 1               5                  10                  15      
Pro Pro Pro Pro Pro Pro Ala Pro Gln Pro Thr Met Ser Arg Arg Lys
            20                  25                  30          
Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu Phe Ser Pro Glu Pro
        35                  40                  45              
Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp His Gly Pro Leu Gly
    50                  55                  60                  
Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys Gly Gln Cys Gln Met
65                  70                  75                  80  
Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile Glu His Lys Arg Lys
                85                  90                  95      
Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala Val Asp Lys Pro Pro
            100                 105                 110         
Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser Asn Pro Val Glu Val
        115                 120                 125             
Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys Leu Ser Thr Ser Ser
    130                 135                 140                 
Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala Asp Lys Leu Leu His
145                 150                 155                 160 
Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His Gly Ala Leu Ile Pro
                165                 170                 175     
Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln Gly Ile Cys Lys Asp
            180                 185                 190         
Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys Gln Pro Phe Thr Ser
        195                 200                 205             
Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr His Gly Leu Arg Ile
    210                 215                 220                 
Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr Pro Arg Val Gly Ile
225                 230                 235                 240 
Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln Pro Pro Leu His Gly
                245                 250                 255     
Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu Leu Arg Ile Pro Gly
            260                 265                 270         
Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu Gly Arg Phe Pro Pro
        275                 280                 285             
Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His His Leu Asp Pro His
    290                 295                 300                 
Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala Leu Ala Thr His His
305                 310                 315                 320 
Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn Pro Met Ala Met Glu
                325                 330                 335     
Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg Glu Leu Ala Gly Asn
            340                 345                 350         
Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro Ser Pro Met Gln Arg
        355                 360                 365             
Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro Pro Phe Leu Ala Thr
    370                 375                 380                 
Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro Pro Ser Gln Pro Pro
385                 390                 395                 400 
Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys Thr Phe Lys Phe Gln
                405                 410                 415     
Ser Asn Leu Val Val His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr
            420                 425                 430         
Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln Ala Ser Lys Leu Lys
        435                 440                 445             
Arg His Met Lys Thr His Met His Lys Ser Ser Pro Met Thr Val Lys
    450                 455                 460                 
Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro Glu Pro Gly Thr Ser
465                 470                 475                 480 
Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys Ser Val Val Ala Lys
                485                 490                 495     
Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro Glu Asn Gly Asp Glu
            500                 505                 510         
Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
        515                 520                 525             
Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp Tyr Gly Phe Gly Leu
    530                 535                 540                 
Ser Leu Glu Ala Ala Arg His His Glu Asn Ser Ser Arg Gly Ala Val
545                 550                 555                 560 
Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro Asp Val Met Gln Gly
                565                 570                 575     
Met Val Leu Ser Ser Met Gln His Phe Ser Glu Ala Phe His Gln Val
            580                 585                 590         
Leu Gly Glu Lys His Lys Arg Gly His Leu Ala Glu Ala Glu Gly His
        595                 600                 605             
Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly Glu Ser Asp Arg Ile
    610                 615                 620                 
Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser Pro Gly Glu Ser Ala
625                 630                 635                 640 
Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly Ser Pro Ser Ser Leu
                645                 650                 655     
Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys Glu Phe Asp Leu Pro
            660                 665                 670         
Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr Ser Gln Trp Leu Ala
        675                 680                 685             
Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro Phe Leu Ser Phe Gly
    690                 695                 700                 
Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser Glu His Ser Ser Glu
705                 710                 715                 720 
Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly Glu Leu Asp Gly Gly
                725                 730                 735     
Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly Ser Thr Pro His Ile
            740                 745                 750         
Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys Glu Gly Arg Arg Ser
        755                 760                 765             
Asp Thr Cys Ser Ser His Thr Pro Ile Arg Arg Ser Thr Gln Arg Ala
    770                 775                 780                 
Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser Arg Ala Leu Lys Phe
785                 790                 795                 800 


<210> 7588
<211> 779
<212> PRT
<213> Homo sapiens

<400> 7588
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu
 1               5                  10                  15      
Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp
            20                  25                  30          
His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys
        35                  40                  45              
Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile
    50                  55                  60                  
Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala
65                  70                  75                  80  
Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser
                85                  90                  95      
Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys
            100                 105                 110         
Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala
        115                 120                 125             
Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His
    130                 135                 140                 
Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln
145                 150                 155                 160 
Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys
                165                 170                 175     
Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr
            180                 185                 190         
His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr
        195                 200                 205             
Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln
    210                 215                 220                 
Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu
225                 230                 235                 240 
Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu
                245                 250                 255     
Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His
            260                 265                 270         
His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala
        275                 280                 285             
Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn
    290                 295                 300                 
Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg
305                 310                 315                 320 
Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro
                325                 330                 335     
Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro
            340                 345                 350         
Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro
        355                 360                 365             
Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys
    370                 375                 380                 
Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr
385                 390                 395                 400 
Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln
                405                 410                 415     
Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser
            420                 425                 430         
Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro
        435                 440                 445             
Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys
    450                 455                 460                 
Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro
465                 470                 475                 480 
Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu
                485                 490                 495     
Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp
            500                 505                 510         
Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser
        515                 520                 525             
Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro
    530                 535                 540                 
Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu
545                 550                 555                 560 
Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala
                565                 570                 575     
Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly
            580                 585                 590         
Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser
        595                 600                 605             
Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly
    610                 615                 620                 
Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys
625                 630                 635                 640 
Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr
                645                 650                 655     
Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro
            660                 665                 670         
Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser
        675                 680                 685             
Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly
    690                 695                 700                 
Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly
705                 710                 715                 720 
Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys
                725                 730                 735     
Glu Gly Arg Arg Ser Asp Thr Phe Ser Asn Leu Phe Leu Gly Ser Ser
            740                 745                 750         
His Thr Pro Ile Arg Arg Ser Thr Gln Arg Ala Gln Asp Val Trp Gln
        755                 760                 765             
Phe Ser Asp Gly Ser Ser Arg Ala Leu Lys Phe
    770                 775                 


<210> 7589
<211> 754
<212> PRT
<213> Homo sapiens

<400> 7589
Met Ala Ser Lys Gln Thr Lys Lys Lys Glu Val His Arg Ile Asn Ser
 1               5                  10                  15      
Ala His Gly Ser Asp Lys Ser Lys Asp Phe Tyr Pro Phe Gly Ser Asn
            20                  25                  30          
Val Gln Ser Gly Ser Thr Glu Gln Lys Lys Gly Lys Phe Pro Leu Trp
        35                  40                  45              
Pro Glu Trp Ser Glu Ala Asp Ile Asn Ser Glu Lys Trp Asp Ala Gly
    50                  55                  60                  
Lys Gly Ala Lys Glu Lys Asp Lys Thr Gly Lys Ser Pro Val Phe His
65                  70                  75                  80  
Phe Phe Glu Asp Pro Glu Gly Lys Ile Glu Leu Pro Pro Ser Leu Lys
                85                  90                  95      
Ile Tyr Ser Trp Lys Arg Pro Gln Asp Ile Leu Phe Ser Gln Thr Pro
            100                 105                 110         
Val Val Val Lys Asn Glu Ile Thr Phe Asp Leu Phe Ser Ala Asn Glu
        115                 120                 125             
His Leu Leu Cys Ser Glu Leu Met Arg Trp Ile Ile Ser Glu Ile Tyr
    130                 135                 140                 
Ala Val Trp Lys Ile Phe Asn Gly Gly Ile Leu Ser Asn Tyr Phe Lys
145                 150                 155                 160 
Gly Thr Ser Gly Glu Pro Pro Leu Leu Pro Trp Lys Pro Trp Glu His
                165                 170                 175     
Ile Tyr Ser Leu Cys Lys Ala Val Lys Gly His Met Pro Leu Phe Asn
            180                 185                 190         
Ser Tyr Gly Lys Tyr Val Val Lys Leu Tyr Trp Met Gly Cys Trp Arg
        195                 200                 205             
Lys Ile Thr Ile Asp Asp Phe Leu Pro Phe Asp Glu Asp Asn Asn Leu
    210                 215                 220                 
Leu Leu Pro Ala Thr Thr Tyr Glu Phe Glu Leu Trp Pro Met Leu Leu
225                 230                 235                 240 
Ser Lys Ala Ile Ile Lys Leu Ala Asn Ile Asp Ile His Val Ala Asp
                245                 250                 255     
Arg Arg Glu Leu Gly Glu Phe Thr Val Ile His Ala Leu Thr Gly Trp
            260                 265                 270         
Leu Pro Glu Val Ile Ser Leu His Pro Gly Tyr Met Asp Lys Val Trp
        275                 280                 285             
Glu Leu Leu Lys Glu Ile Leu Pro Glu Phe Lys Leu Ser Asp Glu Ala
    290                 295                 300                 
Ser Ser Glu Ser Lys Thr Ala Val Leu Asp Ser Lys Leu Lys Glu Pro
305                 310                 315                 320 
Gly Lys Glu Gly Lys Glu Gly Lys Glu Ile Lys Asp Gly Lys Glu Val
                325                 330                 335     
Lys Asp Val Lys Glu Phe Lys Pro Glu Ser Ser Leu Thr Thr Leu Lys
            340                 345                 350         
Ala Pro Glu Lys Ser Asp Lys Val Pro Lys Glu Lys Ala Asp Ala Arg
        355                 360                 365             
Asp Ile Gly Lys Lys Arg Ser Lys Asp Gly Glu Lys Glu Lys Phe Lys
    370                 375                 380                 
Phe Ser Leu His Gly Ser Arg Pro Ser Ser Glu Val Gln Tyr Ser Val
385                 390                 395                 400 
Gln Ser Leu Ser Asp Cys Ser Ser Ala Ile Gln Thr Ser His Met Val
                405                 410                 415     
Val Tyr Ala Thr Phe Thr Pro Leu Tyr Leu Phe Glu Asn Lys Ile Phe
            420                 425                 430         
Ser Leu Glu Lys Met Ala Asp Ser Ala Glu Lys Leu Arg Glu Tyr Gly
        435                 440                 445             
Leu Ser His Ile Cys Ser His Pro Val Leu Val Thr Arg Ser Arg Ser
    450                 455                 460                 
Cys Pro Leu Val Ala Pro Pro Lys Pro Pro Pro Leu Pro Pro Trp Lys
465                 470                 475                 480 
Leu Ile Arg Gln Lys Lys Glu Thr Val Ile Thr Asp Glu Ala Gln Glu
                485                 490                 495     
Leu Ile Val Lys Lys Pro Glu Arg Phe Leu Glu Ile Ser Ser Pro Phe
            500                 505                 510         
Leu Asn Tyr Arg Met Thr Pro Phe Thr Ile Pro Thr Glu Met His Phe
        515                 520                 525             
Val Arg Ser Leu Ile Lys Lys Gly Ile Pro Pro Gly Ser Asp Leu Pro
    530                 535                 540                 
Ser Val Ser Glu Thr Asp Glu Thr Ala Thr His Ser Gln Thr Asp Leu
545                 550                 555                 560 
Ser Gln Ile Thr Lys Ala Thr Ser Gln Gly Asn Thr Ala Ser Gln Val
                565                 570                 575     
Ile Leu Gly Lys Gly Thr Asp Glu Gln Thr Asp Phe Gly Leu Gly Asp
            580                 585                 590         
Ala His Gln Ser Asp Gly Leu Asn Leu Glu Arg Glu Ile Val Ser Gln
        595                 600                 605             
Thr Thr Ala Thr Gln Glu Lys Ser Gln Glu Glu Leu Pro Thr Thr Asn
    610                 615                 620                 
Asn Ser Val Ser Lys Glu Ile Trp Leu Asp Phe Glu Asp Phe Cys Val
625                 630                 635                 640 
Cys Phe Gln Asn Ile Tyr Ile Phe His Lys Pro Ser Ser Tyr Cys Leu
                645                 650                 655     
Asn Phe Gln Lys Ser Glu Phe Lys Phe Ser Glu Glu Arg Val Ser Tyr
            660                 665                 670         
Tyr Leu Phe Val Asp Ser Leu Lys Pro Ile Glu Leu Leu Val Cys Phe
        675                 680                 685             
Ser Ala Leu Val Arg Trp Gly Glu Tyr Gly Ala Leu Thr Lys Asp Ser
    690                 695                 700                 
Pro Pro Ile Glu Pro Gly Leu Leu Thr Ala Glu Thr Phe Ser Trp Lys
705                 710                 715                 720 
Ser Leu Lys Pro Gly Ser Leu Val Leu Lys Ile His Thr Tyr Ala Thr
                725                 730                 735     
Lys Ala Thr Val Val Arg Leu Pro Val Gly Tyr Glu Val Ala Ser Phe
            740                 745                 750         
Phe Pro
        


<210> 7590
<211> 715
<212> PRT
<213> Homo sapiens

<400> 7590
Met Gly Thr Asp Glu Gln Thr Asp Phe Gly Leu Gly Asp Ala His Gln
 1               5                  10                  15      
Ser Asp Gly Leu Asn Leu Glu Arg Glu Ile Val Ser Gln Thr Thr Ala
            20                  25                  30          
Thr Gln Glu Lys Ser Gln Glu Glu Leu Pro Thr Thr Asn Asn Ser Val
        35                  40                  45              
Ser Lys Glu Ile Trp Leu Asp Phe Glu Asp Phe Cys Val Cys Phe Gln
    50                  55                  60                  
Asn Ile Tyr Ile Phe His Lys Pro Ser Ser Tyr Cys Leu Asn Phe Gln
65                  70                  75                  80  
Lys Ser Glu Phe Lys Phe Ser Glu Glu Arg Val Ser Tyr Tyr Leu Phe
                85                  90                  95      
Val Asp Ser Leu Lys Pro Ile Glu Leu Leu Val Cys Phe Ser Ala Leu
            100                 105                 110         
Val Arg Trp Gly Glu Tyr Gly Ala Leu Thr Lys Asp Ser Pro Pro Ile
        115                 120                 125             
Glu Pro Gly Leu Leu Thr Ala Glu Thr Phe Ser Trp Lys Ser Leu Lys
    130                 135                 140                 
Pro Gly Ser Leu Val Leu Lys Ile His Thr Tyr Ala Thr Lys Ala Thr
145                 150                 155                 160 
Val Val Arg Leu Pro Val Gly Arg His Met Leu Leu Phe Asn Ala Tyr
                165                 170                 175     
Ser Pro Val Gly His Ser Ile His Ile Cys Ser Met Val Ser Phe Val
            180                 185                 190         
Ile Gly Asp Glu His Val Val Leu Pro Asn Phe Glu Pro Glu Ser Cys
        195                 200                 205             
Arg Phe Thr Glu Gln Ser Leu Leu Ile Met Lys Ala Ile Gly Asn Val
    210                 215                 220                 
Ile Ala Asn Phe Lys Asp Lys Gly Lys Leu Ser Ala Ala Leu Lys Asp
225                 230                 235                 240 
Leu Gln Thr Ala His Tyr Pro Val Pro Phe His Asp Lys Glu Leu Thr
                245                 250                 255     
Ala Gln His Phe Arg Val Phe His Leu Ser Leu Trp Arg Leu Met Lys
            260                 265                 270         
Lys Val Gln Ile Thr Lys Pro Pro Pro Asn Phe Lys Phe Ala Phe Arg
        275                 280                 285             
Ala Met Val Leu Asp Leu Glu Leu Leu Asn Ser Ser Leu Glu Glu Val
    290                 295                 300                 
Ser Leu Val Glu Trp Leu Asp Val Lys Tyr Cys Met Pro Thr Ser Asp
305                 310                 315                 320 
Lys Glu Tyr Ser Ala Glu Glu Val Ala Ala Ala Ile Lys Ile Gln Ala
                325                 330                 335     
Met Trp Arg Gly Thr Tyr Val Arg Leu Leu Met Lys Ala Arg Ile Pro
            340                 345                 350         
Asp Thr Lys Glu Asn Ile Ser Val Ala Asp Thr Leu Gln Lys Val Trp
        355                 360                 365             
Ala Val Leu Glu Met Asn Leu Glu Gln Tyr Ala Val Ser Leu Leu Arg
    370                 375                 380                 
Leu Met Phe Lys Ser Lys Cys Lys Ser Leu Glu Ser Tyr Pro Cys Tyr
385                 390                 395                 400 
Gln Asp Glu Glu Thr Lys Ile Ala Phe Ala Asp Tyr Thr Val Thr Tyr
                405                 410                 415     
Gln Glu Gln Pro Pro Asn Ser Trp Phe Ile Val Phe Arg Glu Thr Phe
            420                 425                 430         
Leu Val His Gln Asp Met Ile Leu Val Pro Lys Val Tyr Thr Thr Leu
        435                 440                 445             
Pro Ile Cys Ile Leu His Ile Val Asn Asn Asp Thr Met Glu Gln Val
    450                 455                 460                 
Pro Lys Val Phe Gln Lys Val Val Pro Tyr Leu Tyr Thr Lys Asn Lys
465                 470                 475                 480 
Lys Gly Tyr Thr Phe Val Ala Glu Ala Phe Thr Gly Asp Thr Tyr Val
                485                 490                 495     
Ala Ala Ser Arg Trp Lys Leu Arg Leu Ile Gly Ser Ser Ala Pro Leu
            500                 505                 510         
Pro Cys Leu Ser Arg Asp Ser Pro Cys Asn Ser Phe Ala Ile Lys Glu
        515                 520                 525             
Ile Arg Asp Tyr Tyr Ile Pro Asn Asp Lys Lys Ile Leu Phe Arg Tyr
    530                 535                 540                 
Ser Val Lys Val Leu Thr Pro Gln Pro Ala Thr Ile Gln Val Arg Thr
545                 550                 555                 560 
Ser Lys Pro Asp Ala Phe Ile Lys Leu Gln Val Leu Glu Asn Glu Glu
                565                 570                 575     
Thr Met Val Ser Ser Thr Gly Lys Gly Gln Ala Ile Ile Pro Ala Phe
            580                 585                 590         
His Phe Leu Lys Ser Glu Lys Gly Leu Ser Ser Gln Ser Tyr Gly Glu
        595                 600                 605             
Arg His Glu Glu Leu Ile Asn Leu Gly Ser Pro Asp Ser His Thr Ile
    610                 615                 620                 
Ser Glu Gly Gln Lys Ser Ser Val Thr Ser Lys Thr Thr Arg Lys Gly
625                 630                 635                 640 
Lys Glu Lys Ser Ser Glu Lys Glu Lys Thr Ala Lys Glu Lys Gln Ala
                645                 650                 655     
Pro Arg Phe Glu Pro Gln Ile Ser Thr Val His Pro Gln Gln Glu Asp
            660                 665                 670         
Pro Asn Lys Pro Tyr Trp Ile Leu Arg Leu Leu Arg Leu Val Cys Ile
        675                 680                 685             
Thr Leu Ala Gly Ser Leu Arg Lys His Leu Met Leu Arg Val Arg Leu
    690                 695                 700                 
Tyr Leu Lys Ala Lys Leu Asn Gln Lys Lys Lys
705                 710                 715 


<210> 7591
<211> 375
<212> PRT
<213> Homo sapiens

<400> 7591
Met Ser Gly Ser Gln Asn Asn Asp Lys Arg Gln Phe Leu Leu Glu Arg
 1               5                  10                  15      
Leu Leu Asp Ala Val Lys Gln Cys Gln Ile Arg Phe Gly Gly Arg Lys
            20                  25                  30          
Glu Ile Ala Ser Asp Ser Asp Ser Arg Val Thr Cys Leu Cys Ala Gln
        35                  40                  45              
Phe Glu Ala Val Leu Gln His Gly Leu Lys Arg Ser Arg Gly Leu Ala
    50                  55                  60                  
Leu Thr Ala Ala Ala Ile Lys Gln Ala Ala Gly Phe Ala Ser Lys Thr
65                  70                  75                  80  
Glu Thr Glu Pro Val Phe Trp Tyr Tyr Val Lys Glu Val Leu Asn Lys
                85                  90                  95      
His Glu Leu Gln Arg Phe Tyr Ser Leu Arg His Ile Ala Ser Asp Val
            100                 105                 110         
Gly Arg Gly Arg Ala Trp Leu Arg Cys Ala Leu Asn Glu His Ser Leu
        115                 120                 125             
Glu Arg Tyr Leu His Met Leu Leu Ala Asp Arg Cys Arg Leu Ser Thr
    130                 135                 140                 
Phe Tyr Glu Asp Trp Ser Phe Val Met Asp Glu Glu Arg Ser Ser Met
145                 150                 155                 160 
Leu Pro Thr Met Ala Ala Gly Leu Asn Ser Ile Leu Phe Ala Ile Asn
                165                 170                 175     
Ile Asp Asn Lys Asp Leu Asp Gly Gln Ser Lys Phe Ala Pro Thr Val
            180                 185                 190         
Ser Asp Leu Leu Lys Glu Ser Thr Gln Asn Val Thr Ser Leu Leu Lys
        195                 200                 205             
Glu Ser Thr Gln Gly Val Ser Ser Leu Phe Arg Glu Ile Thr Ala Ser
    210                 215                 220                 
Ser Ala Val Ser Ile Leu Ile Lys Pro Glu Gln Glu Thr Asp Pro Leu
225                 230                 235                 240 
Pro Val Val Ser Arg Asn Val Ser Ala Asp Ala Lys Cys Lys Lys Glu
                245                 250                 255     
Arg Lys Lys Lys Lys Lys Val Thr Asn Ile Ile Ser Phe Asp Asp Glu
            260                 265                 270         
Glu Asp Glu Gln Asn Ser Gly Asp Val Phe Lys Lys Thr Pro Gly Ala
        275                 280                 285             
Gly Glu Ser Ser Glu Asp Asn Ser Asp Arg Ser Ser Val Asn Ile Met
    290                 295                 300                 
Ser Ala Phe Glu Ser Pro Phe Gly Pro Asn Ser Asn Gly Ser Gln Ser
305                 310                 315                 320 
Ser Asn Ser Trp Lys Ile Asp Ser Leu Ser Leu Asn Gly Glu Phe Gly
                325                 330                 335     
Tyr Gln Lys Leu Asp Val Lys Gly Ile Asp Asp Glu Asp Val Asp Glu
            340                 345                 350         
Asn Glu Asp Asp Val Tyr Gly Asn Ser Ser Gly Arg Lys His Arg Gly
        355                 360                 365             
His Ser Glu Ser Pro Glu Lys
    370                 375 


<210> 7592
<211> 108
<212> PRT
<213> Homo sapiens

<400> 7592
Gln Lys Ser Asp Ser Glu Cys Ala Glu Gln Leu Arg Gln Leu Ala Arg
 1               5                  10                  15      
Arg Ile Thr Glu Asp His Val Ile Gln His Gly Leu Val Val Asp Gly
            20                  25                  30          
Thr Ser Leu Ser Leu Ala Leu Arg Glu His Glu Lys Leu Leu Met Glu
        35                  40                  45              
Val Cys Arg Asn Cys Ser Ala Val Leu Cys Cys Arg Met Ala Pro Leu
    50                  55                  60                  
Gln Lys Ala Lys Val Ile Arg Leu Ile Lys Ile Ser Pro Glu Lys Pro
65                  70                  75                  80  
Ile Thr Leu Ala Val Gly Asp Gly Ala Asn Asp Glu Ser Trp Val Lys
                85                  90                  95      
Lys Glu Asp Arg Leu Gln Glu Thr Val Thr Met Gln
            100                 105             


<210> 7593
<211> 577
<212> PRT
<213> Homo sapiens

<400> 7593
Met Thr Glu Leu Ala Gly Ala Ser Ser Ser Cys Cys His Arg Pro Ala
 1               5                  10                  15      
Gly Arg Gly Ala Met Gln Ser Val Leu His His Phe Gln Arg Leu Arg
            20                  25                  30          
Gly Arg Glu Gly Gly Ser His Phe Ile Asn Thr Ser Ser Pro Arg Gly
        35                  40                  45              
Glu Ala Lys Met Ser Ile Thr Ser Asp Glu Val Asn Phe Leu Val Tyr
    50                  55                  60                  
Arg Tyr Leu Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly
65                  70                  75                  80  
Ile Glu Ser His Ile Ser Gln Ser Asn Ile Asn Gly Thr Leu Val Pro
                85                  90                  95      
Pro Ala Ala Leu Ile Ser Ile Leu Gln Lys Gly Leu Gln Tyr Val Glu
            100                 105                 110         
Ala Glu Ile Ser Ile Asn Glu Asp Gly Thr Val Phe Asp Gly Arg Pro
        115                 120                 125             
Ile Glu Ser Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val Gln
    130                 135                 140                 
Thr Arg Gln Gln Ala Phe Arg Glu Lys Leu Ala Gln Gln Gln Ala Ser
145                 150                 155                 160 
Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Ala Thr Ala Ala Thr
                165                 170                 175     
Thr Thr Ser Ala Gly Val Ser His Gln Asn Pro Ser Lys Asn Arg Glu
            180                 185                 190         
Ala Thr Val Asn Gly Glu Glu Asn Arg Ala His Ser Val Asn Asn His
        195                 200                 205             
Ala Lys Pro Met Glu Ile Asp Gly Glu Val Glu Ile Pro Ser Ser Lys
    210                 215                 220                 
Ala Thr Val Leu Arg Gly His Glu Ser Glu Val Phe Ile Cys Ala Trp
225                 230                 235                 240 
Asn Pro Val Ser Asp Leu Leu Ala Ser Gly Ser Gly Asp Ser Thr Ala
                245                 250                 255     
Arg Ile Trp Asn Leu Asn Glu Asn Ser Asn Gly Gly Ser Thr Gln Leu
            260                 265                 270         
Val Leu Arg His Cys Ile Arg Glu Gly Gly His Asp Val Pro Ser Asn
        275                 280                 285             
Lys Asp Val Thr Ser Leu Asp Trp Asn Thr Asn Gly Thr Leu Leu Ala
    290                 295                 300                 
Thr Gly Ser Tyr Asp Gly Phe Ala Arg Ile Trp Thr Glu Asp Gly Asn
305                 310                 315                 320 
Leu Ala Ser Thr Leu Gly Gln His Lys Gly Pro Ile Phe Ala Leu Lys
                325                 330                 335     
Trp Asn Arg Lys Gly Asn Tyr Ile Leu Ser Ala Gly Val Asp Lys Thr
            340                 345                 350         
Thr Ile Ile Trp Asp Ala His Thr Gly Glu Ala Lys Gln Gln Phe Pro
        355                 360                 365             
Phe His Ser Ala Pro Ala Leu Asp Val Asp Trp Gln Asn Asn Thr Thr
    370                 375                 380                 
Phe Ala Ser Cys Ser Thr Asp Met Cys Ile His Val Cys Arg Leu Gly
385                 390                 395                 400 
Cys Asp Arg Pro Val Lys Thr Phe Gln Gly His Thr Asn Glu Val Asn
                405                 410                 415     
Ala Ile Lys Trp Asp Pro Ser Gly Met Leu Leu Ala Ser Cys Ser Asp
            420                 425                 430         
Asp Met Thr Leu Lys Ile Trp Ser Met Lys Gln Glu Val Cys Ile His
        435                 440                 445             
Asp Leu Gln Ala His Asn Lys Glu Ile Tyr Thr Ile Lys Trp Ser Pro
    450                 455                 460                 
Thr Gly Pro Ala Thr Ser Asn Pro Asn Ser Asn Ile Met Leu Ala Ser
465                 470                 475                 480 
Ala Ser Phe Asp Ser Thr Val Arg Leu Trp Asp Ile Glu Arg Gly Val
                485                 490                 495     
Cys Thr His Thr Leu Thr Lys His Gln Glu Pro Val Tyr Ser Val Ala
            500                 505                 510         
Phe Ser Pro Asp Gly Lys Tyr Leu Ala Ser Gly Ser Phe Asp Lys Cys
        515                 520                 525             
Val His Ile Trp Asn Thr Gln Ser Gly Asn Leu Val His Ser Tyr Arg
    530                 535                 540                 
Gly Thr Gly Gly Ile Phe Glu Val Cys Trp Asn Ala Arg Gly Asp Lys
545                 550                 555                 560 
Val Gly Ala Ser Ala Ser Asp Gly Ser Val Cys Val Leu Asp Leu Arg
                565                 570                 575     
Lys
    


<210> 7594
<211> 421
<212> PRT
<213> Homo sapiens

<400> 7594
Ser Ile Ser His Phe Pro Leu Thr Ile Ala Cys Asn Ala Gly Phe Ser
 1               5                  10                  15      
Leu Ile Gly Cys Gly Thr Gly Lys Tyr Leu Lys Val Asn Ser Gln Val
            20                  25                  30          
His Thr Val Gly Cys Asp Tyr Cys Gly Pro Leu Val Glu Ile Ala Arg
        35                  40                  45              
Asn Arg Gly Cys Glu Ala Met Val Cys Asp Asn Leu Asn Leu Pro Phe
    50                  55                  60                  
Arg Asp Glu Gly Phe Asp Ala Ile Ile Ser Ile Gly Val Ile His His
65                  70                  75                  80  
Phe Ser Thr Lys Gln Arg Arg Ile Arg Ala Ile Lys Glu Met Ala Arg
                85                  90                  95      
Val Leu Val Pro Gly Gly Gln Leu Met Ile Tyr Val Trp Ala Met Glu
            100                 105                 110         
Gln Lys Asn Arg Arg Phe Glu Lys Gln Asp Val Leu Val Pro Trp Asn
        115                 120                 125             
Arg Ala Leu Cys Ser Gln Leu Phe Ser Glu Ser Ser Gln Ser Gly Arg
    130                 135                 140                 
Lys Arg Gln Cys Gly Tyr Pro Glu Arg Gly His Pro Tyr His Pro Pro
145                 150                 155                 160 
Cys Ser Glu Cys Ser Cys Ser Val Cys Phe Lys Glu Gln Gly Gly Ser
                165                 170                 175     
Lys Arg Ser His Ser Val Gly Tyr Glu Pro Ala Met Ala Arg Thr Cys
            180                 185                 190         
Phe Ala Asn Ile Ser Lys Glu Gly Glu Glu Glu Tyr Gly Phe Tyr Ser
        195                 200                 205             
Thr Leu Gly Lys Ser Phe Arg Ser Trp Phe Phe Ser Arg Ser Leu Asp
    210                 215                 220                 
Glu Ser Thr Leu Arg Lys Gln Ile Glu Arg Val Arg Pro Leu Lys Asn
225                 230                 235                 240 
Thr Glu Val Trp Ala Ser Ser Thr Val Thr Val Gln Pro Ser Arg His
                245                 250                 255     
Ser Ser Leu Asp Phe Asp His Gln Glu Pro Phe Ser Thr Lys Glu Gln
            260                 265                 270         
Ser Leu Asp Glu Glu Val Phe Val Glu Ser Ser Ser Gly Lys His Leu
        275                 280                 285             
Glu Trp Leu Arg Ala Pro Gly Thr Leu Lys His Leu Asn Gly Asp His
    290                 295                 300                 
Gln Gly Glu Met Arg Arg Asn Gly Gly Gly Asn Phe Leu Asp Ser Thr
305                 310                 315                 320 
Asn Thr Gly Val Asn Cys Val Asp Ala Gly Asn Ile Glu Asp Asp Asn
                325                 330                 335     
Pro Ser Ala Ser Lys Ile Leu Arg Arg Ile Ser Ala Val Asp Ser Thr
            340                 345                 350         
Asp Phe Asn Pro Asp Asp Thr Met Ser Val Glu Asp Pro Gln Thr Asp
        355                 360                 365             
Val Leu Asp Ser Thr Ala Phe Met Arg Tyr Tyr His Val Phe Arg Glu
    370                 375                 380                 
Gly Glu Leu Cys Ser Leu Leu Lys Glu Asn Val Ser Glu Leu Arg Ile
385                 390                 395                 400 
Leu Ser Ser Gly Asn Asp His Gly Asn Trp Cys Ile Ile Ala Glu Lys
                405                 410                 415     
Lys Gly Gly Cys Asp
            420     


<210> 7595
<211> 999
<212> PRT
<213> Homo sapiens

<400> 7595
Met Glu Asn Leu Glu Ser Arg Leu Lys Asn Ala Pro Tyr Phe Arg Cys
 1               5                  10                  15      
Glu Lys Gly Thr Asp Ser Asn Pro Leu Cys Arg Lys Cys Glu Thr Cys
            20                  25                  30          
Val Leu Ala Trp Lys Ile Phe Ser Thr Lys Glu Trp Phe Cys Arg Ile
        35                  40                  45              
Asn Asp Ile Ser Gln Arg Arg Phe Leu Val Gly Ile Leu Lys Gln Leu
    50                  55                  60                  
Asn Ser Leu Tyr Leu Leu His Tyr Phe Gln Asn Ile Leu Gln Thr Thr
65                  70                  75                  80  
Gln Gly Lys Asp Phe Ile Tyr Asn Arg Ser Arg Ile Asn Leu Ser Lys
                85                  90                  95      
Lys Glu Gly Lys Val Val Lys Ser Ser Leu Asn Gln Met Leu Asp Lys
            100                 105                 110         
Thr Val Glu Gln Lys Met Lys Glu Ile Leu Tyr Trp Phe Ala Asn Ser
        115                 120                 125             
Thr Gln Trp Thr Lys Ala Asn Tyr Thr Leu Leu Leu Leu Gln Met Cys
    130                 135                 140                 
Asn Pro Lys Leu Leu Leu Thr Ala Ala Asn Val Ile Arg Val Leu Phe
145                 150                 155                 160 
Leu Arg Glu Glu Asn Asn Ile Ser Gly Leu Asn Gln Asp Ile Thr Asp
                165                 170                 175     
Val Cys Phe Ser Pro Glu Lys Asp His Ser Ser Lys Ser Ala Thr Ser
            180                 185                 190         
Gln Val Tyr Trp Thr Ala Lys Thr Gln His Thr Ser Leu Pro Leu Ser
        195                 200                 205             
Lys Ala Pro Glu Asn Glu His Leu Leu Gly Ala Ala Ser Asn Pro Glu
    210                 215                 220                 
Glu Pro Trp Arg Asn Ser Leu Arg Cys Ile Ser Lys Met Asn Arg Leu
225                 230                 235                 240 
Phe Ser Gly Lys Gly Asp Ile Thr Lys Pro Gly Tyr Asp Pro Cys Asn
                245                 250                 255     
Leu Leu Val Asp Leu Asp Asp Ile Arg Asp Leu Ser Ser Gly Phe Ser
            260                 265                 270         
Lys Tyr Arg Asp Phe Ile Arg Tyr Leu Pro Ile His Leu Ser Lys Tyr
        275                 280                 285             
Ile Leu Arg Met Leu Asp Arg His Thr Leu Asn Lys Cys Ala Ser Val
    290                 295                 300                 
Ser Gln His Trp Ala Ala Met Ala Gln Gln Val Lys Met Asp Leu Ser
305                 310                 315                 320 
Ala His Gly Phe Ile Gln Asn Gln Ile Thr Phe Leu Gln Gly Ser Tyr
                325                 330                 335     
Thr Arg Gly Ile Asp Pro Asn Tyr Ala Asn Lys Val Ser Ile Pro Val
            340                 345                 350         
Pro Lys Met Val Asp Asp Gly Lys Ser Met Arg Val Lys His Pro Lys
        355                 360                 365             
Trp Lys Leu Arg Thr Lys Asn Glu Tyr Asn Leu Trp Thr Ala Tyr Gln
    370                 375                 380                 
Asn Glu Glu Thr Gln Gln Val Leu Ile Glu Glu Arg Asn Val Phe Cys
385                 390                 395                 400 
Gly Thr Tyr Asn Val Arg Ile Leu Ser Asp Thr Trp Val Gln Asn Arg
                405                 410                 415     
Val Ile His Tyr Ser Gly Gly Asp Leu Ile Ala Val Ser Ser Asn Arg
            420                 425                 430         
Lys Ile His Leu Leu Asp Ile Ile Gln Val Lys Ala Ile Pro Val Glu
        435                 440                 445             
Phe Arg Gly His Ala Gly Ser Val Arg Ala Leu Phe Leu Cys Glu Glu
    450                 455                 460                 
Glu Asn Phe Leu Leu Ser Gly Ser Tyr Asp Leu Ser Ile Arg Tyr Trp
465                 470                 475                 480 
Asp Leu Lys Ser Gly Val Cys Thr Arg Ile Phe Gly Gly His Gln Gly
                485                 490                 495     
Thr Ile Thr Cys Met Asp Leu Cys Lys Asn Arg Leu Val Ser Gly Gly
            500                 505                 510         
Arg Asp Cys Gln Val Lys Val Trp Asp Val Asp Thr Gly Lys Cys Leu
        515                 520                 525             
Lys Thr Phe Arg His Lys Asp Pro Ile Leu Ala Thr Arg Ile Asn Asp
    530                 535                 540                 
Thr Tyr Ile Val Ser Ser Cys Glu Arg Gly Leu Val Lys Val Trp His
545                 550                 555                 560 
Ile Ala Met Ala Gln Leu Val Lys Thr Leu Ser Gly His Glu Gly Ala
                565                 570                 575     
Val Lys Cys Leu Phe Phe Asp Gln Trp His Leu Leu Ser Gly Ser Thr
            580                 585                 590         
Asp Gly Leu Val Met Ala Trp Ser Met Val Gly Lys Tyr Glu Arg Cys
        595                 600                 605             
Leu Met Ala Phe Lys His Pro Lys Met Val Val Asn Thr Glu Ser Asn
    610                 615                 620                 
Val Leu Met Phe Gln Phe Glu His Ile Lys Trp Gln Tyr Ala Val Glu
625                 630                 635                 640 
Lys Thr Lys Gln Lys Lys Asn Lys Glu Lys Glu Glu Glu Lys Glu Glu
                645                 650                 655     
Asn Ser Leu Met Glu Ile Leu Ser Lys Cys Asn Ile Gln Val His Ser
            660                 665                 670         
Pro Arg Glu Ser Val Ser Ser Lys Gln Thr Val Ile Gln Glu Leu Leu
        675                 680                 685             
Pro Gly Lys Pro Pro Lys Ser Arg Val Leu Leu Lys Pro Ala Lys Phe
    690                 695                 700                 
Ser Ser Ala Val Leu Ile Glu Glu Leu Gln Ser Gln Gly Lys Ser Lys
705                 710                 715                 720 
Ser Pro Arg Arg Asp Ala Asp Asp Val Glu Lys Ala Gln Lys Gln Gly
                725                 730                 735     
Gln Leu Glu Thr Pro Gly Lys Leu Pro Ser His Pro Lys Lys Lys Ser
            740                 745                 750         
Trp Lys Ile Pro Met Ser Pro Asp Gln Phe Leu Leu Thr Val Ser Thr
        755                 760                 765             
Leu Gln His Ala His Asn Ser Gly Glu Phe Ala Tyr Pro Cys Arg Pro
    770                 775                 780                 
Gln Thr Glu Ile Thr Asp Val Trp Gly Pro Ser Ile Ser Tyr Pro Arg
785                 790                 795                 800 
Lys Val Leu Asn Phe Lys Gly Lys Ser Ile Gln Arg Ala Val Asp Arg
                805                 810                 815     
Leu Arg Leu Ser Asn Pro Pro Ile Asp Val Lys Arg Thr Ser Ile Pro
            820                 825                 830         
Leu Glu Ile Gln Lys Leu Gln Pro Asn Leu Lys Ile Ser Leu His Ser
        835                 840                 845             
Pro Arg Val Gln Ser Thr Ile Pro Gln Pro Met Ile Ile Arg Ser Arg
    850                 855                 860                 
Phe Ser Gly Ser Leu Lys Gly Gly Asp Gln Val Thr Ser Ser Ile Glu
865                 870                 875                 880 
Arg Ala Val Cys Ser Thr Gly Pro Leu Thr Ser Met Gln Val Ile Lys
                885                 890                 895     
Pro Asn Arg Met Leu Ala Pro Gln Val Gly Thr Ala Thr Leu Ser Leu
            900                 905                 910         
Lys Lys Glu Arg Pro Arg Ile Tyr Thr Ala Leu Asp Pro Phe Arg Val
        915                 920                 925             
Asn Thr Glu Phe Val Leu Leu Thr Val Lys Glu Glu Lys Glu His Gln
    930                 935                 940                 
Glu Ala Lys Met Lys Glu Tyr Gln Ala Arg Glu Ser Thr Gly Val Val
945                 950                 955                 960 
Asp Pro Gly Lys Val Ser Lys Ala Ala Trp Ile Arg Lys Ile Lys Gly
                965                 970                 975     
Leu Pro Ile Asp Asn Phe Thr Lys Gln Gly Lys Thr Ala Ala Pro Glu
            980                 985                 990         
Leu Gly Gln Asn Val Phe Ile
        995                 


<210> 7596
<211> 1061
<212> PRT
<213> Homo sapiens

<400> 7596
Met Glu Asn Leu Glu Ser Arg Leu Lys Asn Ala Pro Tyr Phe Arg Cys
 1               5                  10                  15      
Glu Lys Gly Thr Asp Ser Ile Pro Leu Cys Arg Lys Cys Glu Thr Cys
            20                  25                  30          
Val Leu Ala Trp Lys Ile Phe Ser Thr Lys Glu Trp Phe Cys Arg Ile
        35                  40                  45              
Asn Asp Ile Ser Gln Arg Arg Phe Leu Val Gly Ile Leu Lys Gln Leu
    50                  55                  60                  
Asn Ser Leu Tyr Leu Leu His Tyr Phe Gln Asn Ile Leu Gln Thr Thr
65                  70                  75                  80  
Gln Gly Lys Asp Phe Ile Tyr Asn Arg Ser Arg Ile Asn Leu Ser Lys
                85                  90                  95      
Lys Glu Gly Lys Val Val Lys Ser Ser Leu Asn Gln Met Leu Asp Lys
            100                 105                 110         
Thr Val Glu Gln Lys Met Lys Glu Ile Leu Tyr Trp Phe Ala Asn Ser
        115                 120                 125             
Thr Gln Trp Thr Lys Ala Asn Tyr Thr Leu Leu Leu Leu Gln Met Cys
    130                 135                 140                 
Asn Pro Lys Leu Leu Leu Thr Ala Ala Asn Val Ile Arg Val Leu Phe
145                 150                 155                 160 
Leu Arg Glu Glu Asn Asn Ile Ser Gly Leu Asn Gln Asp Ile Thr Asp
                165                 170                 175     
Val Cys Phe Ser Pro Glu Lys Asp His Ser Ser Lys Ser Ala Thr Ser
            180                 185                 190         
Gln Val Tyr Trp Thr Ala Lys Thr Gln His Thr Ser Leu Pro Leu Ser
        195                 200                 205             
Lys Ala Pro Glu Asn Glu His Leu Leu Gly Ala Ala Ser Asn Pro Glu
    210                 215                 220                 
Glu Pro Trp Arg Asn Ser Leu Arg Cys Ile Ser Glu Met Asn Arg Leu
225                 230                 235                 240 
Phe Ser Gly Lys Gly Asp Ile Thr Lys Pro Gly Tyr Asp Pro Cys Asn
                245                 250                 255     
Leu Leu Val Asp Leu Asp Asp Ile Arg Asp Leu Ser Ser Gly Phe Ser
            260                 265                 270         
Lys Tyr Leu Asp Phe Ile Arg Tyr Leu Pro Ile His Leu Ser Lys Tyr
        275                 280                 285             
Ile Leu Ser Met Leu Gly Cys Met Arg Gly Phe Pro Arg His Leu Pro
    290                 295                 300                 
Ser Trp Pro Ser Ser Gly Val Ser Gly Ser Ile Phe Phe Phe Pro Gly
305                 310                 315                 320 
Met Leu Asp Arg His Thr Leu Asn Lys Cys Ala Ser Val Ser Gln His
                325                 330                 335     
Trp Ala Ala Met Ala Gln Gln Val Lys Met Asp Leu Ser Ala His Gly
            340                 345                 350         
Phe Ile Gln Asn Gln Ile Thr Phe Leu Gln Gly Ser Tyr Thr Arg Gly
        355                 360                 365             
Ile Asp Pro Asn Tyr Ala Asn Lys Val Ser Ile Pro Val Pro Lys Met
    370                 375                 380                 
Val Asp Asp Gly Lys Ser Met Arg Val Lys His Pro Lys Trp Lys Leu
385                 390                 395                 400 
Arg Thr Lys Asn Glu Tyr Asn Leu Trp Thr Ala Tyr Gln Asn Glu Glu
                405                 410                 415     
Thr Gln Gln Val Leu Ile Glu Glu Arg Asn Val Phe Cys Gly Thr Tyr
            420                 425                 430         
Asn Val Arg Ile Leu Ser Asp Thr Trp Asp Gln Asn Arg Val Ile His
        435                 440                 445             
Tyr Ser Gly Gly Asp Leu Ile Ala Val Ser Ser Asn Arg Lys Ile His
    450                 455                 460                 
Leu Leu Asp Ile Ile Gln Val Lys Ala Ile Pro Val Glu Phe Arg Gly
465                 470                 475                 480 
His Ala Gly Ser Val Arg Ala Leu Phe Leu Cys Glu Glu Glu Asn Phe
                485                 490                 495     
Leu Leu Ser Gly Ser Tyr Asp Leu Ser Ile Arg Tyr Trp Asp Leu Lys
            500                 505                 510         
Ser Gly Val Cys Thr Arg Ile Phe Gly Gly His Gln Gly Thr Ile Thr
        515                 520                 525             
Cys Met Asp Leu Cys Lys Asn Arg Leu Val Ser Gly Gly Arg Asp Cys
    530                 535                 540                 
Gln Val Lys Val Trp Asp Val Asp Thr Gly Lys Cys Leu Lys Thr Phe
545                 550                 555                 560 
Arg His Lys Asp Pro Ile Leu Ala Thr Arg Ile Asn Asp Thr Tyr Ile
                565                 570                 575     
Val Ser Ser Cys Glu Arg Gly Leu Val Lys Val Trp His Ile Ala Met
            580                 585                 590         
Ala Gln Leu Val Lys Thr Leu Ser Gly His Glu Gly Ala Val Lys Cys
        595                 600                 605             
Leu Phe Phe Asp Gln Trp His Leu Leu Ser Gly Ser Thr Asp Gly Leu
    610                 615                 620                 
Val Met Ala Trp Ser Met Val Gly Lys Tyr Glu Arg Cys Leu Met Ala
625                 630                 635                 640 
Phe Lys His Pro Lys Glu Val Leu Asp Val Ser Leu Leu Phe Leu Arg
                645                 650                 655     
Val Ile Ser Ala Cys Ala Asp Gly Lys Ile Arg Ile Tyr Asn Phe Leu
            660                 665                 670         
Asn Gly Asn Cys Met Lys Val Leu Lys Ala Asn Gly Arg Gly Asp Pro
        675                 680                 685             
Val Leu Ser Phe Phe Ile Gln Gly Asn Arg Met Val Val Asn Thr Glu
    690                 695                 700                 
Ser Asn Val Leu Met Phe Gln Phe Glu His Ile Lys Trp Gln Tyr Ala
705                 710                 715                 720 
Val Glu Lys Thr Lys Gln Lys Lys Asn Lys Glu Lys Glu Glu Glu Lys
                725                 730                 735     
Glu Glu Asn Ser Leu Met Glu Ile Leu Ser Lys Cys Asn Ile Gln Val
            740                 745                 750         
His Ser Pro Arg Glu Ser Val Ser Ser Lys Gln Thr Val Ile Gln Glu
        755                 760                 765             
Leu Leu Pro Gly Lys Pro Pro Lys Ser Arg Val Leu Leu Lys Pro Ala
    770                 775                 780                 
Lys Phe Ser Ser Asp Asp Val Glu Lys Ala Gln Lys Gln Gly Gln Leu
785                 790                 795                 800 
Glu Thr Pro Gly Lys Leu Pro Ser His Pro Lys Lys Lys Ser Trp Lys
                805                 810                 815     
Ile Pro Met Ser Pro Asp Gln Phe Leu Leu Thr Val Ser Ala Leu Gln
            820                 825                 830         
His Ala His Asn Ser Gly Glu Phe Ala Tyr Pro Cys Arg Pro Gln Thr
        835                 840                 845             
Glu Ile Thr Asp Val Trp Gly Pro Ser Ile Ser Tyr Pro Arg Lys Val
    850                 855                 860                 
Leu Asn Phe Lys Gly Lys Ser Ile Gln Arg Ala Val Asp Arg Leu Arg
865                 870                 875                 880 
Leu Ser Asn Pro Pro Ile Asp Val Lys Arg Thr Ser Ile Pro Leu Glu
                885                 890                 895     
Ile Gln Lys Leu Gln Pro Asn Leu Lys Ile Ser Leu His Ser Pro Arg
            900                 905                 910         
Val Gln Ser Thr Ile Pro Gln Pro Met Ile Ile Arg Ser Arg Phe Ser
        915                 920                 925             
Gly Ser Leu Lys Gly Gly Asp Gln Val Thr Ser Ser Ile Glu Arg Ala
    930                 935                 940                 
Val Cys Ser Thr Gly Pro Leu Thr Ser Met Gln Val Ile Lys Pro Asn
945                 950                 955                 960 
Arg Met Leu Ala Pro Gln Val Gly Thr Ala Thr Leu Ser Leu Lys Lys
                965                 970                 975     
Glu Arg Pro Arg Ile Tyr Thr Ala Leu Asp Pro Phe Arg Val Asn Thr
            980                 985                 990         
Glu Phe Val Leu Leu Thr Val Lys Glu Glu Lys Glu His Gln Glu Ala
        995                 1000                1005            
Lys Met Lys Glu Tyr Gln Ala Arg Glu Ser Thr Gly Val Val Asp Pro
    1010                1015                1020                
Gly Lys Val Ser Lys Ala Ala Trp Ile Arg Lys Ile Lys Gly Leu Pro
1025                1030                1035                1040
Ile Asp Asn Phe Thr Lys Gln Gly Lys Thr Ala Ala Pro Glu Leu Gly
                1045                1050                1055    
Gln Asn Val Phe Ile
            1060    


<210> 7597
<211> 511
<212> PRT
<213> Homo sapiens

<400> 7597
Met Ser Thr Leu Leu Ile Asn Gln Pro Gln Tyr Ala Trp Leu Lys Glu
 1               5                  10                  15      
Leu Gly Leu Arg Glu Glu Asn Glu Gly Val Tyr Asn Gly Ser Trp Gly
            20                  25                  30          
Gly Arg Gly Glu Val Ile Thr Thr Tyr Cys Pro Ala Asn Asn Glu Pro
        35                  40                  45              
Ile Ala Arg Val Arg Gln Ala Ser Val Ala Asp Tyr Glu Glu Thr Val
    50                  55                  60                  
Lys Lys Ala Arg Glu Ala Trp Lys Ile Trp Ala Asp Ile Pro Ala Pro
65                  70                  75                  80  
Lys Arg Gly Glu Ile Val Arg Gln Ile Gly Asp Ala Leu Arg Glu Lys
                85                  90                  95      
Ile Gln Val Leu Gly Ser Leu Val Ser Leu Glu Met Gly Lys Ile Leu
            100                 105                 110         
Val Glu Gly Val Gly Glu Val Gln Glu Tyr Val Asp Ile Cys Asp Tyr
        115                 120                 125             
Ala Val Gly Leu Ser Arg Met Ile Gly Gly Pro Ile Leu Pro Ser Glu
    130                 135                 140                 
Arg Ser Gly His Ala Leu Ile Glu Gln Trp Asn Pro Val Gly Leu Val
145                 150                 155                 160 
Gly Ile Ile Thr Ala Phe Asn Phe Pro Val Ala Val Tyr Gly Trp Asn
                165                 170                 175     
Asn Ala Ile Ala Met Ile Cys Gly Asn Val Cys Leu Trp Lys Gly Ala
            180                 185                 190         
Pro Thr Thr Ser Leu Ile Ser Val Ala Val Thr Lys Ile Ile Ala Lys
        195                 200                 205             
Val Leu Glu Asp Asn Lys Leu Pro Gly Ala Ile Cys Ser Leu Thr Cys
    210                 215                 220                 
Gly Gly Ala Asp Ile Gly Thr Ala Met Ala Lys Asp Glu Arg Val Asn
225                 230                 235                 240 
Leu Leu Ser Phe Thr Gly Ser Thr Gln Val Gly Lys Gln Val Gly Leu
                245                 250                 255     
Met Val Gln Glu Arg Phe Gly Arg Ser Leu Leu Glu Leu Gly Gly Asn
            260                 265                 270         
Asn Ala Ile Ile Ala Phe Glu Asp Ala Asp Leu Ser Leu Val Val Pro
        275                 280                 285             
Ser Ala Leu Phe Ala Ala Val Gly Thr Ala Gly Gln Arg Cys Thr Thr
    290                 295                 300                 
Ala Arg Arg Leu Phe Ile His Glu Ser Ile His Asp Glu Val Val Asn
305                 310                 315                 320 
Arg Leu Lys Lys Ala Tyr Ala Gln Ile Arg Val Gly Asn Pro Trp Asp
                325                 330                 335     
Pro Asn Val Leu Tyr Gly Pro Leu His Thr Lys Gln Ala Val Ser Met
            340                 345                 350         
Phe Leu Gly Ala Val Glu Glu Ala Lys Lys Glu Gly Gly Thr Val Val
        355                 360                 365             
Tyr Gly Gly Lys Val Met Asp Arg Pro Gly Asn Tyr Val Glu Pro Thr
    370                 375                 380                 
Ile Val Thr Gly Leu Gly His Asp Ala Ser Ile Ala His Thr Glu Thr
385                 390                 395                 400 
Phe Ala Pro Ile Leu Tyr Val Phe Lys Phe Lys Asn Glu Glu Glu Val
                405                 410                 415     
Phe Ala Trp Asn Asn Glu Val Lys Gln Gly Leu Ser Ser Ser Ile Phe
            420                 425                 430         
Thr Lys Asp Leu Gly Arg Ile Phe Arg Trp Leu Gly Pro Lys Gly Ser
        435                 440                 445             
Asp Cys Gly Ile Val Asn Val Asn Ile Pro Thr Ser Gly Ala Glu Ile
    450                 455                 460                 
Gly Gly Ala Phe Gly Gly Glu Lys His Thr Gly Gly Gly Arg Glu Ser
465                 470                 475                 480 
Gly Ser Asp Ala Trp Lys Gln Tyr Met Arg Arg Ser Thr Cys Thr Ile
                485                 490                 495     
Asn Tyr Ser Lys Asp Leu Pro Leu Ala Gln Gly Ile Lys Phe Gln
            500                 505                 510     


<210> 7598
<211> 1205
<212> PRT
<213> Homo sapiens

<400> 7598
Met Ile Trp Pro Thr Gly Leu Leu Arg Gly Phe Arg Phe Trp Ala Ser
 1               5                  10                  15      
Val Ser Pro Pro Val Leu Asp Leu Thr His Phe Thr Gly Leu Gln Gly
            20                  25                  30          
Gly Trp Gly Gly Gly Gly Arg Arg Gln Cys Gly Pro Glu Ala Ala Ser
        35                  40                  45              
Ala Gly Ser Cys Ser Ala Glu Thr Pro Ser Pro Pro Pro Arg Ala Pro
    50                  55                  60                  
Gly Arg Gly Pro Ile Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys
65                  70                  75                  80  
Thr Pro Ser Ile Ser Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln
                85                  90                  95      
Pro Ser Gly Glu Leu Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro
            100                 105                 110         
Gly Pro Ser Leu Glu Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr
        115                 120                 125             
Gly Thr Leu Lys Arg Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala
    130                 135                 140                 
Gly Phe Pro Leu Ser Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His
145                 150                 155                 160 
Arg Ser Pro Leu Thr Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly
                165                 170                 175     
Ala Gly Pro Asp Val Val Glu Asp Ile Ser His Leu Leu Ala Asp Val
            180                 185                 190         
Ala Arg Phe Ala Glu Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg
        195                 200                 205             
Asp Asp Leu Leu Glu Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly
    210                 215                 220                 
Glu Ala Leu Arg Val Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu
225                 230                 235                 240 
Asn Thr Val Glu Thr Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val
                245                 250                 255     
Lys Ala Phe His Tyr Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe
            260                 265                 270         
Glu Lys Ala Leu Glu Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser
        275                 280                 285             
Glu Phe Leu Met Gly Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro
    290                 295                 300                 
Pro Gly Asp Ser Ser Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser
305                 310                 315                 320 
Glu Gly Thr Pro Pro Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro
                325                 330                 335     
Ala Glu Glu Val Asp Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp
            340                 345                 350         
Ala Ala Leu Leu Tyr Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu
        355                 360                 365             
Ile Ser Tyr Leu Glu Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys
    370                 375                 380                 
Gly Leu Gln Lys Ile Ala His Asn Cys Arg Gln Ser Val Met Gln Glu
385                 390                 395                 400 
Pro His Met Pro Leu Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp
                405                 410                 415     
Leu Glu Phe Gly His Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr
            420                 425                 430         
Gln Thr Phe Met Gln Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys
        435                 440                 445             
Arg Arg Lys Glu Ile Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu
    450                 455                 460                 
Gln Glu Ala Glu Ser Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln
465                 470                 475                 480 
Arg Cys Glu Asp His Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu
                485                 490                 495     
Glu Glu Gln Ala Gly Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys
            500                 505                 510         
Thr Leu Asp Lys Arg Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala
        515                 520                 525             
Glu Glu Ala Met Ala Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr
    530                 535                 540                 
Gln Lys Gln Glu Leu Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile
545                 550                 555                 560 
Gln Glu Val Ile Arg Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile
                565                 570                 575     
Ser Tyr Tyr Gln Met Met His Met Gln Thr Ala Pro Leu Pro Val His
            580                 585                 590         
Phe Gln Met Leu Cys Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln
        595                 600                 605             
Tyr Ala Ser His Val Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val
    610                 615                 620                 
His Tyr Asp Phe Glu Pro His Val Ser Ala Asn Ala Trp Ser Pro Val
625                 630                 635                 640 
Met Arg Ala Arg Lys Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro
                645                 650                 655     
Glu Ala Ala Gly Ser Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr
            660                 665                 670         
Pro Ala Lys Asp His Arg Ala Gly Arg Gly His Gln Val His Lys Ser
        675                 680                 685             
Trp Pro Leu Ser Ile Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro
    690                 695                 700                 
Gly Ala Gly Asp Phe Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr
705                 710                 715                 720 
Met Ser Ser Thr Glu Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala
                725                 730                 735     
Ser Ala Phe Glu Gln Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro
            740                 745                 750         
Val Ala Val Pro Ser Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala
        755                 760                 765             
Ala Arg Thr His Arg Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg
    770                 775                 780                 
Glu Cys Asn Ser Tyr Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys
785                 790                 795                 800 
Cys Leu Ala Cys His Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys
                805                 810                 815     
Gly His Lys Lys Leu Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe
            820                 825                 830         
Ser His Ala Ala Arg Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys
        835                 840                 845             
Lys Cys Val Cys Glu Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile
    850                 855                 860                 
Tyr Arg Val Asn Gly Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala
865                 870                 875                 880 
Phe Glu Asn Gly Lys Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His
                885                 890                 895     
Asp Ile Ser Asn Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro
            900                 905                 910         
Leu Ile Ser Phe Arg Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp
        915                 920                 925             
Ser Leu Lys Ala Glu Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln
    930                 935                 940                 
Asp Gly Ser Glu Ser Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu
945                 950                 955                 960 
Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln
                965                 970                 975     
Tyr Leu Leu Arg His Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn
            980                 985                 990         
Lys Met Thr Pro Gly Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu
        995                 1000                1005            
Arg Pro Arg Pro Thr Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp
    1010                1015                1020                
Tyr Pro His Gln Ala Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly
1025                1030                1035                1040
Leu Val Phe Glu Glu Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu
                1045                1050                1055    
Ser Ser Asn Gln Arg Ala Glu Val Val Val Gln Val Pro Tyr Leu Glu
            1060                1065                1070        
Ala Gly Glu Ala Val Val Tyr Pro Leu Gln Glu Ala Ala Ala Asp Gly
        1075                1080                1085            
Cys Arg Glu Ser Arg Val Val Ser Asn Asp Ser Asp Ser Asp Leu Glu
    1090                1095                1100                
Glu Ala Ser Glu Leu Leu Ser Ser Ser Glu Ala Ser Ala Leu Gly His
1105                1110                1115                1120
Leu Ser Phe Leu Glu Gln Gln Gln Ser Glu Ala Ser Leu Glu Val Ala
                1125                1130                1135    
Ser Gly Ser His Ser Gly Ser Glu Glu Gln Leu Glu Ala Thr Ala Arg
            1140                1145                1150        
Glu Asp Gly Asp Gly Asp Glu Asp Gly Pro Ala Gln Gln Leu Ser Gly
        1155                1160                1165            
Phe Asn Thr Asn Gln Ser Asn Asn Val Leu Gln Ala Pro Leu Pro Pro
    1170                1175                1180                
Met Arg Leu Arg Gly Gly Arg Met Thr Leu Gly Ser Cys Arg Glu Arg
1185                1190                1195                1200
Gln Pro Glu Phe Val
                1205


<210> 7599
<211> 736
<212> PRT
<213> Homo sapiens

<400> 7599
Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg
 1               5                  10                  15      
Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu
            20                  25                  30          
Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu
        35                  40                  45              
Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu
    50                  55                  60                  
Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn
65                  70                  75                  80  
Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr
                85                  90                  95      
Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala
            100                 105                 110         
Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu
        115                 120                 125             
Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu
    130                 135                 140                 
Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro
145                 150                 155                 160 
Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val
                165                 170                 175     
Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro
            180                 185                 190         
Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys
        195                 200                 205             
Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val
    210                 215                 220                 
Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Ile
225                 230                 235                 240 
Ala Ala Lys Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val Leu
                245                 250                 255     
Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro Arg
            260                 265                 270         
Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro Lys
        275                 280                 285             
Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser His
    290                 295                 300                 
Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser Pro
305                 310                 315                 320 
Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu Met
                325                 330                 335     
Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met Gly
            340                 345                 350         
Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro Phe
        355                 360                 365             
Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly Pro
    370                 375                 380                 
Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro Thr
385                 390                 395                 400 
Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala Pro
                405                 410                 415     
Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu Leu
            420                 425                 430         
Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile Leu
        435                 440                 445             
Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp Ile
    450                 455                 460                 
Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro Ser
465                 470                 475                 480 
Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val Asn
                485                 490                 495     
Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu Asn
            500                 505                 510         
Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg Ser
        515                 520                 525             
Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn Leu
    530                 535                 540                 
Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn Glu
545                 550                 555                 560 
Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser Met
                565                 570                 575     
Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His Ala
            580                 585                 590         
Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr Thr
        595                 600                 605             
Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala Leu
    610                 615                 620                 
Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val Val
625                 630                 635                 640 
Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr Ile
                645                 650                 655     
Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro Glu
            660                 665                 670         
Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro Trp
        675                 680                 685             
Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met Arg
    690                 695                 700                 
Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr Val
705                 710                 715                 720 
Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg Leu
                725                 730                 735     


<210> 7600
<211> 769
<212> PRT
<213> Homo sapiens

<400> 7600
Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg
 1               5                  10                  15      
Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu
            20                  25                  30          
Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu
        35                  40                  45              
Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu
    50                  55                  60                  
Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn
65                  70                  75                  80  
Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr
                85                  90                  95      
Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala
            100                 105                 110         
Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu
        115                 120                 125             
Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu
    130                 135                 140                 
Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro
145                 150                 155                 160 
Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val
                165                 170                 175     
Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro
            180                 185                 190         
Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys
        195                 200                 205             
Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val
    210                 215                 220                 
Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Ile
225                 230                 235                 240 
Ala Ala Lys Lys His Pro Phe Tyr Thr Ser Pro Ala Val Val Met Ala
                245                 250                 255     
His Gly Glu Gln Pro Ile Pro Gly Leu Ile Asn Tyr Ser His His Ser
            260                 265                 270         
Thr Asp Glu Arg Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val
        275                 280                 285             
Leu Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro
    290                 295                 300                 
Arg Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro
305                 310                 315                 320 
Lys Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser
                325                 330                 335     
His Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser
            340                 345                 350         
Pro Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu
        355                 360                 365             
Met Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met
    370                 375                 380                 
Gly Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro
385                 390                 395                 400 
Phe Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly
                405                 410                 415     
Pro Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro
            420                 425                 430         
Thr Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala
        435                 440                 445             
Pro Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu
    450                 455                 460                 
Leu Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile
465                 470                 475                 480 
Leu Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp
                485                 490                 495     
Ile Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro
            500                 505                 510         
Ser Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val
        515                 520                 525             
Asn Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu
    530                 535                 540                 
Asn Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg
545                 550                 555                 560 
Ser Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn
                565                 570                 575     
Leu Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn
            580                 585                 590         
Glu Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser
        595                 600                 605             
Met Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His
    610                 615                 620                 
Ala Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr
625                 630                 635                 640 
Thr Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala
                645                 650                 655     
Leu Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val
            660                 665                 670         
Val Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr
        675                 680                 685             
Ile Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro
    690                 695                 700                 
Glu Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro
705                 710                 715                 720 
Trp Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met
                725                 730                 735     
Arg Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr
            740                 745                 750         
Val Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg
        755                 760                 765             
Leu
    


<210> 7601
<211> 202
<212> PRT
<213> Homo sapiens

<400> 7601
Met Met Lys Lys Thr Thr Met Asp Leu Asn Ile Arg Asp Ala Lys Lys
 1               5                  10                  15      
Arg Thr Ala Leu His Trp Ala Cys Ala Asn Gly His Ala Glu Val Val
            20                  25                  30          
Thr Leu Leu Ala Asp Arg Lys Tyr Gln Leu Asp Val Leu Asp Gly Glu
        35                  40                  45              
Asn Arg Thr Thr Leu Met Lys Ala Leu Gln Cys Gln Arg Glu Ala Cys
    50                  55                  60                  
Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Pro Asn Ile Val Gly Val
65                  70                  75                  80  
Tyr Gly Asn Thr Ala Val His Tyr Ala Val Asn Ser Glu Asn Leu Ser
                85                  90                  95      
Val Val Ala Lys Leu Leu Ser Cys Gly Ala Asp Ile Glu Leu Lys Asn
            100                 105                 110         
Lys Ala Gly His Thr Pro Leu Leu Leu Ala Ile Arg Lys Arg Ser Glu
        115                 120                 125             
Gln Ile Val Glu Phe Leu Leu Thr Lys Asn Ala Asn Ala Ile Ala Val
    130                 135                 140                 
Asp Lys Phe Lys Cys Ile His Gln Gln Leu Leu Glu Tyr Lys Gln Lys
145                 150                 155                 160 
Ile Ser Lys Asn Ser Gln Asn Ser Asn Pro Glu Gly Thr Ser Glu Gly
                165                 170                 175     
Thr Leu Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala
            180                 185                 190         
Glu Ser Leu Val Glu Arg Thr Pro Asp Glu
        195                 200         


<210> 7602
<211> 704
<212> PRT
<213> Homo sapiens

<400> 7602
Met Ala Val Pro Pro Arg Gly Gly Arg Ala Ala His Met Ala Ala Ile
 1               5                  10                  15      
Arg Ala Leu Gln Gln Trp Cys Arg Gln Gln Cys Glu Gly Tyr Arg Asp
            20                  25                  30          
Val Asn Ile Cys Asn Met Thr Ser His Leu Pro Ala Ala Ala Ser Ala
        35                  40                  45              
Ser Pro Lys Leu Thr Gly Leu Val Pro Arg Gln Pro Gly Ala Met Gly
    50                  55                  60                  
Val Asp Ser Arg Thr Ser Cys Ser Pro Gln Lys Ala Gln Glu Ala Asn
65                  70                  75                  80  
Lys Ala Arg Pro Leu Ala Trp Glu Pro Ala Ala Gly Asn Ser Pro Ala
                85                  90                  95      
Arg Ala Ser Val Pro Ala Ala Pro Asn Pro Ala Ala Thr Ser Ala Thr
            100                 105                 110         
Ser Val His Val Arg Ser Pro Ala Arg Pro Ser Glu Ser Arg Leu Ala
        115                 120                 125             
Pro Thr Pro Thr Glu Gly Lys Val Arg Pro Arg Val Thr Asn Ser Ser
    130                 135                 140                 
Pro Met Gly Trp Ser Ser Ala Ala Pro Cys Thr Ala Ala Ala Ala Ser
145                 150                 155                 160 
His Pro Ala Val Pro Pro Ser Ala Pro Asp Pro Arg Pro Ala Thr Pro
                165                 170                 175     
Gln Gly Gly Gly Ala Pro Arg Val Ala Ala Pro Gln Thr Thr Leu Ser
            180                 185                 190         
Ser Ser Ser Thr Ser Ala Ala Thr Val Asp Pro Pro Ala Trp Thr Pro
        195                 200                 205             
Ser Ala Ser Arg Thr Gln Gln Ala Arg Asn Lys Phe Phe Gln Thr Ser
    210                 215                 220                 
Ala Val Pro Pro Gly Thr Ser Leu Ser Gly Arg Gly Pro Thr Pro Ser
225                 230                 235                 240 
Leu Val Leu Ser Lys Asp Ser Ser Lys Glu Gln Ala Arg Asn Phe Leu
                245                 250                 255     
Lys Gln Ala Leu Ser Ala Leu Glu Glu Ala Gly Ala Pro Ala Pro Gly
            260                 265                 270         
Arg Pro Ser Pro Ala Thr Ala Ala Val Pro Ser Ser Gln Pro Lys Thr
        275                 280                 285             
Glu Ala Pro Gln Ala Ser Pro Leu Ala Lys Pro Leu Gln Ser Ser Ser
    290                 295                 300                 
Pro Arg Val Leu Gly Leu Pro Ser Arg Met Glu Pro Pro Ala Pro Leu
305                 310                 315                 320 
Ser Thr Ser Ser Thr Ser Gln Ala Ser Ala Leu Pro Pro Ala Gly Arg
                325                 330                 335     
Arg Asn Leu Ala Glu Ser Ser Gly Val Gly Arg Val Gly Ala Gly Ser
            340                 345                 350         
Arg Pro Lys Pro Glu Ala Pro Met Ala Lys Gly Lys Ser Thr Thr Leu
        355                 360                 365             
Thr Gln Asp Met Ser Thr Ser Leu Gln Glu Gly Gln Glu Asp Gly Pro
    370                 375                 380                 
Ala Gly Trp Arg Ala Asn Leu Lys Pro Val Asp Arg Arg Ser Pro Ala
385                 390                 395                 400 
Glu Arg Thr Leu Lys Pro Lys Glu Pro Arg Ala Leu Ala Glu Pro Arg
                405                 410                 415     
Ala Gly Glu Ala Pro Arg Lys Val Ser Gly Ser Phe Ala Gly Ser Val
            420                 425                 430         
His Ile Thr Leu Thr Pro Val Arg Pro Asp Arg Thr Pro Arg Pro Ala
        435                 440                 445             
Ser Pro Gly Pro Ser Leu Pro Ala Arg Ser Pro Ser Pro Pro Arg Arg
    450                 455                 460                 
Arg Arg Leu Ala Val Pro Ala Ser Leu Asp Val Cys Asp Asn Trp Leu
465                 470                 475                 480 
Arg Pro Glu Pro Pro Gly Gln Glu Ala Arg Val Gln Ser Trp Lys Glu
                485                 490                 495     
Glu Glu Lys Lys Pro His Leu Gln Gly Arg Pro Gly Arg Pro Leu Ser
            500                 505                 510         
Pro Ala Asn Val Pro Ala Leu Pro Gly Glu Thr Val Thr Ser Pro Val
        515                 520                 525             
Arg Leu His Pro Asp Tyr Leu Ser Pro Glu Glu Ile Gln Arg Gln Leu
    530                 535                 540                 
Gln Asp Ile Glu Arg Arg Leu Asp Ala Leu Glu Leu Arg Gly Val Glu
545                 550                 555                 560 
Leu Glu Lys Arg Leu Arg Ala Ala Glu Gly Asp Asp Ala Glu Asp Ser
                565                 570                 575     
Leu Met Val Asp Trp Phe Trp Leu Ile His Glu Lys Gln Leu Leu Leu
            580                 585                 590         
Arg Gln Glu Ser Glu Leu Met Tyr Lys Ser Lys Ala Gln Arg Leu Glu
        595                 600                 605             
Glu Gln Gln Leu Asp Ile Glu Gly Glu Leu Arg Arg Leu Met Ala Lys
    610                 615                 620                 
Pro Glu Ala Leu Lys Ser Leu Gln Glu Arg Arg Arg Glu Gln Glu Leu
625                 630                 635                 640 
Leu Glu Gln Tyr Val Ser Thr Val Asn Asp Arg Ser Asp Ile Val Asp
                645                 650                 655     
Ser Leu Asp Glu Asp Arg Leu Arg Glu Gln Glu Glu Asp Gln Met Leu
            660                 665                 670         
Arg Asp Met Ile Glu Lys Leu Gly Leu Gln Arg Lys Lys Ser Lys Phe
        675                 680                 685             
Arg Leu Ser Lys Ile Trp Ser Pro Lys Ser Lys Ser Ser Pro Ser Gln
    690                 695                 700                 


<210> 7603
<211> 533
<212> PRT
<213> Homo sapiens

<400> 7603
Met Ala His Gly Ser Val Thr Phe Arg Asp Val Ala Ile Asp Phe Ser
 1               5                  10                  15      
Gln Glu Glu Trp Glu Phe Leu Asp Pro Ala Gln Arg Asp Leu Tyr Arg
            20                  25                  30          
Asp Val Met Trp Glu Asn Tyr Ser Asn Phe Ile Ser Leu Gly Pro Ser
        35                  40                  45              
Ile Ser Lys Pro Asp Val Ile Thr Leu Leu Asp Glu Glu Arg Lys Glu
    50                  55                  60                  
Pro Gly Met Val Val Arg Glu Gly Thr Arg Arg Tyr Cys Pro Asp Leu
65                  70                  75                  80  
Glu Ser Arg Tyr Arg Thr Asn Thr Leu Ser Pro Glu Lys Asp Ile Tyr
                85                  90                  95      
Glu Ile Tyr Ser Phe Gln Trp Asp Ile Met Glu Arg Ile Lys Ser Tyr
            100                 105                 110         
Ser Leu Gln Gly Ser Ile Phe Arg Asn Asp Trp Glu Cys Lys Ser Lys
        115                 120                 125             
Ile Glu Gly Glu Lys Glu Gln Gln Glu Gly Tyr Phe Gly Gln Val Lys
    130                 135                 140                 
Ile Thr Ser Glu Lys Met Thr Thr Tyr Lys Arg His Asn Phe Leu Thr
145                 150                 155                 160 
Glu Tyr Gln Ile Val His Asn Gly Glu Lys Val Tyr Glu Cys Lys Glu
                165                 170                 175     
Cys Arg Lys Thr Phe Ile Arg Arg Ser Thr Leu Ser Gln His Leu Arg
            180                 185                 190         
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Gln Ala
        195                 200                 205             
Phe Arg Gln Arg Ala His Leu Ile Arg His His Lys Leu His Thr Gly
    210                 215                 220                 
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Thr Val Leu
225                 230                 235                 240 
Gln Glu Leu Thr Gln His Gln Arg Leu His Thr Gly Glu Lys Pro Tyr
                245                 250                 255     
Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Val His Gln Gln Leu Ala
            260                 265                 270         
Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Asp
        275                 280                 285             
Cys Gly Lys Thr Phe Arg Gln Cys Thr His Leu Thr Arg His Gln Arg
    290                 295                 300                 
Leu His Thr Ala Glu Lys Leu Tyr Glu Cys Lys Glu Cys Gly Lys Ala
305                 310                 315                 320 
Phe Val Cys Gly Pro Asp Leu Arg Val His Gln Lys Ile His Phe Gly
                325                 330                 335     
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Ile Cys
            340                 345                 350         
Gln Gln Leu Thr Val His Gln Ser Ile His Thr Gly Glu Lys Pro Tyr
        355                 360                 365             
Glu Cys Lys Glu Cys Gly Lys Thr Phe Arg Leu Arg Gln Gln Leu Val
    370                 375                 380                 
Arg His Gln Arg Ile His Thr Arg Glu Lys Pro Tyr Glu Cys Met Glu
385                 390                 395                 400 
Cys Trp Lys Thr Phe Ser Ser Tyr Ser Gln Leu Ile Ser His Gln Ser
                405                 410                 415     
Ile His Ile Gly Glu Arg Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala
            420                 425                 430         
Phe Arg Leu Leu Ser Gln Leu Thr Gln His Gln Ser Ile His Thr Gly
        435                 440                 445             
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Arg Lys Pro Phe Arg Leu Leu
    450                 455                 460                 
Ser Gln Leu Thr Gln His Gln Ser Ile His Thr Gly Glu Lys Pro Tyr
465                 470                 475                 480 
Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Leu Tyr Ser Phe Leu Thr
                485                 490                 495     
Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu
            500                 505                 510         
Cys Lys Lys Ala Phe Arg Gln His Ser His Leu Thr Gln His Gln Lys
        515                 520                 525             
Ile His Asn Gly Ile
    530             


<210> 7604
<211> 522
<212> PRT
<213> Homo sapiens

<400> 7604
Met Ala Val Ser His Leu Pro Thr Met Val Gln Glu Ser Val Thr Phe
 1               5                  10                  15      
Lys Asp Val Ala Ile Leu Phe Thr Gln Glu Glu Trp Gly Gln Leu Ser
            20                  25                  30          
Pro Ala Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser
        35                  40                  45              
Asn Leu Val Ser Leu Gly Leu Leu Gly Pro Lys Pro Asp Thr Phe Ser
    50                  55                  60                  
Gln Leu Glu Lys Arg Glu Val Trp Met Pro Glu Asp Thr Pro Gly Gly
65                  70                  75                  80  
Phe Cys Leu Asp Trp Met Thr Met Pro Ala Ser Lys Lys Ser Thr Val
                85                  90                  95      
Lys Ala Glu Ile Pro Glu Glu Glu Leu Asp Gln Trp Thr Ile Lys Glu
            100                 105                 110         
Arg Phe Ser Ser Ser Ser His Trp Lys Cys Ala Ser Leu Leu Glu Trp
        115                 120                 125             
Gln Cys Gly Gly Gln Glu Ile Ser Leu Gln Arg Val Val Leu Thr His
    130                 135                 140                 
Pro Asn Thr Pro Ser Gln Glu Tyr Asp Glu Ser Gly Ser Thr Met Ser
145                 150                 155                 160 
Ser Ser Leu His Ser Asp Gln Ser Gln Gly Phe Gln Pro Ser Lys Asn
                165                 170                 175     
Ala Phe Glu Cys Ser Glu Cys Gly Lys Val Phe Ser Lys Ser Ser Thr
            180                 185                 190         
Leu Asn Lys His Gln Lys Ile His Asn Glu Lys Asn Ala Asn Gln Lys
        195                 200                 205             
Ile His Ile Lys Glu Lys Arg Tyr Glu Cys Arg Glu Cys Gly Lys Ala
    210                 215                 220                 
Phe His Gln Ser Thr His Leu Ile His His Gln Arg Ile His Thr Gly
225                 230                 235                 240 
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Val Ser
                245                 250                 255     
Ser Ser Leu Thr Tyr His Gln Lys Ile His Thr Gly Glu Lys Pro Phe
            260                 265                 270         
Glu Cys Asn Leu Cys Gly Lys Ala Phe Ile Arg Asn Ile His Leu Ala
        275                 280                 285             
His His His Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn Ile
    290                 295                 300                 
Cys Glu Lys Ala Phe Val Cys Arg Ala His Leu Thr Lys His Gln Asn
305                 310                 315                 320 
Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala
                325                 330                 335     
Phe Asn Gln Ser Thr Ser Phe Leu Gln His Gln Arg Ile His Thr Gly
            340                 345                 350         
Glu Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe Arg Val Asn
        355                 360                 365             
Ser Ser Leu Thr Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
    370                 375                 380                 
Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg Asp Asn Ser Ser Phe Ala
385                 390                 395                 400 
Arg His Arg Lys Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Gly Leu
                405                 410                 415     
Cys Glu Lys Ala Phe Arg Asp Gln Ser Ala Leu Ala Gln His Gln Arg
            420                 425                 430         
Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Asn Ile Cys Glu Lys Ala
        435                 440                 445             
Phe Ser Asp His Ser Ala Leu Thr Gln His Lys Arg Ile His Thr Arg
    450                 455                 460                 
Glu Lys Pro Tyr Lys Cys Lys Ile Cys Glu Lys Ala Phe Ile Arg Ser
465                 470                 475                 480 
Thr His Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
                485                 490                 495     
Lys Cys Asn Lys Cys Gly Lys Ala Phe Asn Gln Thr Ala Asn Leu Ile
            500                 505                 510         
Gln His Gln Arg His His Ile Gly Glu Lys
        515                 520         


<210> 7605
<211> 231
<212> PRT
<213> Homo sapiens

<400> 7605
Val His Thr Gly Cys Cys Gln Arg Pro Leu Arg Phe Gln Ala Leu Gly
 1               5                  10                  15      
Gly Glu Gly Gln Ser Ala Asp Leu Arg Pro Leu Leu Thr Asp Phe Arg
            20                  25                  30          
Leu Gln Phe Ile Cys Ala Pro Ala Ser Ser Leu Ser Leu Arg Arg Leu
        35                  40                  45              
Arg Leu Arg Pro Gln Lys Glu Ile Ser Ile Leu Cys Pro Glu Gln Asn
    50                  55                  60                  
Arg Met Ala Met Ser Gln Glu Ser Leu Thr Phe Lys Asp Val Phe Val
65                  70                  75                  80  
Asp Phe Thr Leu Glu Glu Trp Gln Gln Leu Asp Ser Ala Gln Lys Asn
                85                  90                  95      
Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val
            100                 105                 110         
Gly Tyr Leu Val Ala Lys Pro Asp Val Ile Phe Arg Leu Gly Pro Gly
        115                 120                 125             
Glu Glu Ser Trp Met Ala Asp Gly Gly Thr Pro Val Arg Thr Cys Ala
    130                 135                 140                 
Glu Val Trp Gln Val Asp Glu Gln Ile Asp His Tyr Lys Glu Ser Gln
145                 150                 155                 160 
Asp Lys Leu Pro Trp Gln Ala Ala Phe Ile Gly Lys Glu Thr Leu Lys
                165                 170                 175     
Asp Glu Ser Gly Gln Glu Ser Arg Thr Cys Arg Lys Ser Ile Tyr Leu
            180                 185                 190         
Ser Thr Glu Phe Asp Ser Val Arg Gln Arg Leu Pro Lys Tyr Tyr Ser
        195                 200                 205             
Trp Glu Lys Ala Phe Lys Thr Ser Phe Lys Leu Ser Trp Ser Lys Trp
    210                 215                 220                 
Lys Leu Cys Lys Lys Glu Arg
225                 230     


<210> 7606
<211> 98
<212> PRT
<213> Homo sapiens

<400> 7606
Met Ala Met Ser Gln Glu Ser Leu Thr Phe Lys Asp Val Phe Val Asp
 1               5                  10                  15      
Phe Thr Leu Glu Glu Trp Gln Gln Leu Asp Ser Ala Gln Lys Asn Leu
            20                  25                  30          
Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly
        35                  40                  45              
Tyr Leu Val Ala Lys Pro Asp Val Ile Phe Arg Leu Gly Pro Gly Glu
    50                  55                  60                  
Glu Ser Trp Met Ala Asp Gly Gly Thr Pro Val Arg Thr Cys Ala Gly
65                  70                  75                  80  
Glu Asp Arg Pro Asp Val Ser Ile Phe Ala Ser Cys Ile Leu Lys Cys
                85                  90                  95      
Cys Tyr
        


<210> 7607
<211> 480
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 170, 400
<223> Xaa = Any Amino Acid

<400> 7607
Met Ala Gln Ala Asp Ile Val Leu Ile Arg Leu Ala Val Met Gly Gln
 1               5                  10                  15      
Asn Leu Ile Leu Thr Met Lys Asp His Gly Phe Val Val Cys Ala Phe
            20                  25                  30          
Asn Arg Thr Val Ser Glu Val Asp Asp Phe Leu Ala Asn Glu Ala Lys
        35                  40                  45              
Gly Thr Lys Val Val Gly Ala Gln Ser Leu Lys Glu Met Val Ser Lys
    50                  55                  60                  
Leu Lys Lys Pro Gln Arg Ile Ile Leu Leu Val Lys Ala Gly Gln Ala
65                  70                  75                  80  
Val Asp Tyr Phe Ile Lys Lys Leu Ile Pro Leu Leu Asp Ile Gly Asp
                85                  90                  95      
Ile Ile Ile Asp Gly Gly Asn Ser Glu Tyr Arg Asp Thr Thr Arg Arg
            100                 105                 110         
Cys Gln Asp Leu Lys Ala Lys Gly Ile Leu Phe Val Gly Ser Gly Val
        115                 120                 125             
Ser Gly Gly Glu Glu Gly Ala Trp Tyr Gly Ser Leu Leu Thr Pro Gly
    130                 135                 140                 
Gly Asn Lys Glu Ala Trp Pro His Ile Lys Thr Ile Phe Gln Gly Val
145                 150                 155                 160 
Ala Ala Lys Val Gly Pro Cys Cys Asp Xaa Val Gly Asp Glu Gly Ala
                165                 170                 175     
Gly His Phe Val Lys Met Ala His Asn Arg Ile Glu Tyr Gly Asp Met
            180                 185                 190         
Gln Leu Ile Cys Glu Ala Tyr His Leu Met Lys Asp Val Leu Gly Met
        195                 200                 205             
Ala Gln Asp Lys Met Ala Gln Ala Phe Glu Asp Trp Asn Lys Thr Glu
    210                 215                 220                 
Leu Asp Ser Phe Leu Ile Glu Ile Thr Ala Asn Ile Leu Lys Phe Gln
225                 230                 235                 240 
Gly Ala Asp Gly Lys His Leu Leu Pro Lys Ile Arg Asp Ser Ala Gly
                245                 250                 255     
Gln Lys Gly Met Gly Lys Trp Thr Thr Ile Ser Ala Leu Glu Tyr Gly
            260                 265                 270         
Ile Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Trp Cys Leu Ser
        275                 280                 285             
Ser Leu Lys Asp Gly Arg Ile Gln Ala Ser Lys Lys Leu Lys Gly Pro
    290                 295                 300                 
Gln Lys Phe Gln Phe Asp Gly Asp Lys Lys Ser Phe Leu Glu Asp Ile
305                 310                 315                 320 
Arg Met Ser Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln Gly Phe
                325                 330                 335     
Met Leu Leu Arg Gln Gly Ala Thr Glu Phe Gly Trp Thr Leu Asn Tyr
            340                 345                 350         
Gly Asp Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg Ser Val
        355                 360                 365             
Phe Leu Gly Lys Ile Lys Asp Ala Phe Asp Arg Asn Pro Glu Pro Gln
    370                 375                 380                 
Asn Leu Leu Leu Asp Asp Phe Leu Lys Ser Ala Val Glu Asn His Xaa
385                 390                 395                 400 
Asp Ser Trp Trp Trp Ala Val Ser Thr Gly Val Gln Ala Gly Ile Pro
                405                 410                 415     
Met Pro Cys Phe Val Thr Ala Leu Ser Phe Tyr Asp Lys Tyr Arg His
            420                 425                 430         
Glu Met Leu Pro Ala Asn Leu Ile Gln Ala Gln Arg Asp Ser Phe Gly
        435                 440                 445             
Ala His Thr Tyr Glu Leu Leu Ala Lys Pro Gly Gln Phe Ile His Thr
    450                 455                 460                 
Asn Trp Thr Gly His Gly Gly Ser Val Ser Ser Ser Ser Tyr Asn Ala
465                 470                 475                 480 


<210> 7608
<211> 392
<212> PRT
<213> Homo sapiens

<400> 7608
Met Glu Ala Pro Leu Val Ser Leu Asp Glu Glu Phe Glu Asp Leu Arg
 1               5                  10                  15      
Pro Ser Cys Ser Glu Asp Pro Glu Glu Lys Pro Gln Cys Phe Tyr Gly
            20                  25                  30          
Ser Ser Pro His His Leu Glu Asp Pro Ser Leu Ser Glu Leu Glu Asn
        35                  40                  45              
Phe Ser Ser Glu Ile Ile Ser Phe Lys Ser Met Glu Asp Leu Val Asn
    50                  55                  60                  
Glu Phe Asp Glu Lys Leu Asn Val Cys Phe Arg Asn Tyr Asn Ala Lys
65                  70                  75                  80  
Thr Glu Asn Leu Ala Pro Val Lys Asn Gln Leu Gln Ile Gln Glu Glu
                85                  90                  95      
Glu Glu Thr Leu Gln Asp Glu Glu Val Trp Asp Ala Leu Thr Asp Asn
            100                 105                 110         
Tyr Ile Pro Ser Leu Ser Glu Asp Trp Arg Asp Pro Asn Ile Glu Ala
        115                 120                 125             
Leu Asn Gly Asn Cys Ser Asp Thr Glu Ile His Glu Lys Glu Glu Glu
    130                 135                 140                 
Glu Phe Asn Glu Lys Ser Glu Asn Asp Ser Gly Ile Asn Glu Glu Pro
145                 150                 155                 160 
Leu Leu Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met Gln
                165                 170                 175     
Asn Ser Pro Asp Pro Glu Glu Glu Glu Glu Val Leu Glu Glu Glu Asp
            180                 185                 190         
Gly Gly Glu Thr Ser Ser Gln Ala Asp Ser Val Leu Leu Gln Glu Met
        195                 200                 205             
Gln Ala Leu Thr Gln Thr Phe Asn Asn Asn Trp Ser Tyr Glu Gly Leu
    210                 215                 220                 
Arg His Met Ser Gly Ser Glu Leu Thr Glu Leu Leu Asp Gln Val Glu
225                 230                 235                 240 
Gly Ala Ile Arg Asp Phe Ser Glu Glu Leu Val Gln Gln Leu Ala Arg
                245                 250                 255     
Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile Thr
            260                 265                 270         
Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu Gln Arg Glu Leu Met
        275                 280                 285             
Lys Lys Arg Arg Lys Glu Lys Gly Leu Ser Leu Gln Ser Ser Arg Ile
    290                 295                 300                 
Glu Lys Gly Asn Gln Met Pro Leu Lys Arg Phe Ser Met Glu Gly Ile
305                 310                 315                 320 
Ser Asn Ile Leu Gln Ser Gly Ile Arg Gln Thr Phe Gly Ser Ser Gly
                325                 330                 335     
Thr Asp Lys Gln Tyr Leu Asn Thr Val Ile Pro Tyr Glu Lys Lys Ala
            340                 345                 350         
Ser Pro Pro Ser Val Glu Asp Leu Gln Met Leu Thr Asn Ile Leu Phe
        355                 360                 365             
Ala Met Lys Glu Asp Asn Glu Lys Val Pro Thr Leu Leu Thr Asp Tyr
    370                 375                 380                 
Ile Leu Lys Val Leu Cys Pro Thr
385                 390         


<210> 7609
<211> 391
<212> PRT
<213> Homo sapiens

<400> 7609
Ser Arg Asp Asn Gly Pro Asp Gly Met Glu Pro Glu Cys Val Ile Glu
 1               5                  10                  15      
Ser Asn Trp Asn Glu Ile Val Asp Ser Phe Asp Asp Met Asn Leu Ser
            20                  25                  30          
Glu Ser Leu Leu Arg Asp Ile Tyr Ala Tyr Gly Phe Glu Lys Pro Ser
        35                  40                  45              
Ala Ile Gln Gln Gln Ala Ile Leu Pro Cys Ile Arg Gly Tyr Asn Val
    50                  55                  60                  
Ile Ala Gln Ala Arg Ser Gly Thr Gly Lys Met Ala Thr Phe Ala Ile
65                  70                  75                  80  
Ser Ile Leu Gln Gln Ile Glu Leu Asp Leu Lys Ala Thr Gln Ala Leu
                85                  90                  95      
Val Leu Ala Pro Thr Arg Glu Leu Ala Gln Gln Ile Gln Lys Val Val
            100                 105                 110         
Met Ala Leu Val Asp Tyr Met Gly Ala Ser Cys His Ala Cys Val Arg
        115                 120                 125             
Gly Thr Asn Met Arg Ala Glu Val Gln Lys Leu Gln Met Glu Ala Pro
    130                 135                 140                 
His Ile Ile Val Gly Thr Pro Ser Arg Val Phe Asp Met Leu Asn Gln
145                 150                 155                 160 
Arg Tyr Leu Ser Pro Lys Tyr Ile Lys Met Phe Val Leu Asp Lys Ala
                165                 170                 175     
Asp Glu Met Leu Ser Arg Gly Phe Lys Asp Gln Ile Tyr Asp Ile Phe
            180                 185                 190         
Gln Lys Leu Asn Ser Asn Thr Gln Val Val Leu Leu Ser Ala Thr Met
        195                 200                 205             
Pro Ser Asp Met Leu Glu Val Ile Lys Lys Phe Met Arg Asp Pro Ile
    210                 215                 220                 
Arg Ile Leu Val Lys Lys Glu Glu Leu Thr Leu Glu Gly Ile Arg Gln
225                 230                 235                 240 
Phe Tyr Ile Asn Val Glu Gln Glu Glu Trp Lys Leu Asp Thr Leu Cys
                245                 250                 255     
Asp Leu Tyr Glu Thr Leu Thr Ile Thr Gln Glu Val Ile Phe Ile Asn
            260                 265                 270         
Thr Arg Arg Lys Val Asp Trp Leu Thr Glu Lys Met His Ala Arg Asp
        275                 280                 285             
Phe Thr Val Ser Ala Met His Gly Asp Met Asp Gln Lys Glu Gln Asp
    290                 295                 300                 
Val Ile Met Arg Glu Phe His Ser Gly Ser Ser Arg Val Leu Ile Thr
305                 310                 315                 320 
Thr Asp Leu Leu Ala Arg Gly Ile Asp Val Gln Gln Val Ser Leu Val
                325                 330                 335     
Ile Asn Tyr Asp Leu Pro Thr Asn Arg Glu Asn Tyr Ile His Arg Ile
            340                 345                 350         
Ser Arg Gly Gly Arg Phe Gly Arg Lys Gly Val Ala Ile Asn Met Val
        355                 360                 365             
Thr Glu Glu Asp Lys Arg Thr Leu Gln Asp Ile Glu Ile Phe Tyr Asn
    370                 375                 380                 
Thr Ser Ile Glu Glu Met Pro
385                 390     


<210> 7610
<211> 1289
<212> PRT
<213> Homo sapiens

<400> 7610
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu
 1               5                  10                  15      
Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro
            20                  25                  30          
Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr
        35                  40                  45              
Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser
    50                  55                  60                  
Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro
65                  70                  75                  80  
Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala
                85                  90                  95      
Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile
            100                 105                 110         
Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe
        115                 120                 125             
Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val
    130                 135                 140                 
Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val
145                 150                 155                 160 
Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu
                165                 170                 175     
Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp
            180                 185                 190         
Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp
        195                 200                 205             
Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg
    210                 215                 220                 
Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro
225                 230                 235                 240 
Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp
                245                 250                 255     
Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg
            260                 265                 270         
Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Val Asn His Leu
        275                 280                 285             
Val Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn
    290                 295                 300                 
Ile Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys
305                 310                 315                 320 
Asn His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala
                325                 330                 335     
Glu Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile
            340                 345                 350         
Asn Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys
        355                 360                 365             
Asp Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile
    370                 375                 380                 
Glu Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln
385                 390                 395                 400 
Val Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Lys Leu Glu
                405                 410                 415     
Lys Gln Leu Gln Lys Asp Lys Glu Lys Val Glu Glu Phe Lys Ser Ile
            420                 425                 430         
Pro Ala Lys Ser Asn Asn Ile Ile Asn Glu Thr Thr Thr Arg Asn Asn
        435                 440                 445             
Ala Leu Glu Lys Glu Lys Glu Lys Glu Glu Lys Lys Leu Lys Glu Val
    450                 455                 460                 
Met Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu
465                 470                 475                 480 
Ser Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala
                485                 490                 495     
Arg Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser
            500                 505                 510         
Arg His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu
        515                 520                 525             
Ile Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp
    530                 535                 540                 
Ile Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu
545                 550                 555                 560 
Lys Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu
                565                 570                 575     
Val His Asp Leu Phe Gln Lys Val Glu Glu Ala Lys Ser Ser Leu Ala
            580                 585                 590         
Met Asn Arg Ser Arg Gly Lys Val Leu Asp Ala Ile Ile Gln Glu Lys
        595                 600                 605             
Lys Ser Gly Arg Ile Pro Gly Ile Tyr Gly Arg Leu Gly Asp Leu Gly
    610                 615                 620                 
Ala Ile Asp Glu Lys Tyr Asp Val Ala Ile Ser Ser Cys Cys His Ala
625                 630                 635                 640 
Leu Asp Tyr Ile Val Val Asp Ser Ile Asp Ile Ala Gln Glu Cys Val
                645                 650                 655     
Asn Phe Leu Lys Arg Gln Asn Ile Gly Val Ala Thr Phe Ile Gly Leu
            660                 665                 670         
Asp Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro
        675                 680                 685             
Glu Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys
    690                 695                 700                 
Ile Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp
705                 710                 715                 720 
Asn Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp
                725                 730                 735     
Arg Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met
            740                 745                 750         
Thr Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu
        755                 760                 765             
Val Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu
    770                 775                 780                 
Gln Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln
785                 790                 795                 800 
Leu Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg
                805                 810                 815     
Asn Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln
            820                 825                 830         
Glu Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu
        835                 840                 845             
Ala Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val
    850                 855                 860                 
Ser Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Gly Lys
865                 870                 875                 880 
Val Glu Ala Glu Val Lys Arg Leu His Asn Thr Ile Val Glu Ile Asn
                885                 890                 895     
Asn His Lys Leu Lys Ala Gln Gln Asp Lys Leu Asp Lys Ile Asn Lys
            900                 905                 910         
Gln Leu Asp Glu Cys Ala Ser Ala Ile Thr Lys Ala Gln Val Ala Ile
        915                 920                 925             
Lys Thr Ala Asp Arg Asn Leu Gln Lys Ala Gln Asp Ser Val Leu Arg
    930                 935                 940                 
Thr Glu Lys Glu Ile Lys Asp Thr Glu Lys Glu Val Asp Asp Leu Thr
945                 950                 955                 960 
Ala Glu Leu Lys Ser Leu Glu Asp Lys Ala Ala Glu Val Val Lys Asn
                965                 970                 975     
Thr Asn Ala Ala Glu Glu Ser Leu Pro Glu Ile Gln Lys Glu His Arg
            980                 985                 990         
Asn Leu Leu Gln Glu Leu Lys Val Ile Gln Glu Asn Glu His Ala Leu
        995                 1000                1005            
Gln Lys Asp Ala Leu Ser Ile Lys Leu Lys Leu Glu Gln Ile Asp Gly
    1010                1015                1020                
His Ile Ala Glu His Asn Ser Lys Ile Lys Tyr Trp His Lys Glu Ile
1025                1030                1035                1040
Ser Lys Ile Ser Leu His Pro Ile Glu Asp Asn Pro Ile Glu Glu Ile
                1045                1050                1055    
Ser Val Leu Ser Pro Glu Asp Leu Glu Ala Ile Lys Asn Pro Asp Ser
            1060                1065                1070        
Ile Thr Asn Gln Ile Ala Leu Leu Glu Ala Arg Cys His Glu Met Lys
        1075                1080                1085            
Pro Asn Leu Gly Ala Ile Ala Glu Tyr Lys Lys Lys Glu Glu Leu Tyr
    1090                1095                1100                
Leu Gln Arg Val Ala Glu Leu Asp Lys Ile Thr Tyr Glu Arg Asp Ser
1105                1110                1115                1120
Phe Arg Gln Ala Tyr Glu Asp Leu Arg Lys Gln Arg Leu Asn Glu Phe
                1125                1130                1135    
Met Ala Gly Phe Tyr Ile Ile Thr Asn Lys Leu Lys Glu Asn Tyr Gln
            1140                1145                1150        
Met Leu Thr Leu Gly Gly Asp Ala Glu Leu Glu Leu Val Asp Ser Leu
        1155                1160                1165            
Asp Pro Phe Ser Glu Gly Ile Met Phe Ser Val Arg Pro Pro Lys Lys
    1170                1175                1180                
Ser Trp Lys Lys Ile Phe Asn Leu Ser Gly Gly Glu Lys Thr Leu Ser
1185                1190                1195                1200
Ser Leu Ala Leu Val Phe Ala Leu His His Tyr Lys Pro Thr Pro Leu
                1205                1210                1215    
Tyr Phe Met Asp Glu Ile Asp Ala Ala Leu Asp Phe Lys Asn Val Ser
            1220                1225                1230        
Ile Val Ala Phe Tyr Ile Tyr Glu Gln Thr Lys Asn Ala Gln Phe Ile
        1235                1240                1245            
Ile Ile Ser Leu Arg Asn Asn Met Phe Glu Ile Ser Asp Arg Leu Ile
    1250                1255                1260                
Gly Ile Tyr Lys Thr Tyr Asn Ile Thr Lys Ser Val Ala Val Asn Pro
1265                1270                1275                1280
Lys Glu Ile Ala Ser Lys Gly Leu Cys
                1285                


<210> 7611
<211> 1230
<212> PRT
<213> Homo sapiens

<400> 7611
Met Pro Arg Lys Gly Thr Gln Pro Ser Thr Ala Arg Arg Arg Glu Glu
 1               5                  10                  15      
Gly Pro Pro Pro Pro Ser Pro Asp Gly Ala Ser Ser Asp Ala Glu Pro
            20                  25                  30          
Glu Pro Pro Ser Gly Arg Thr Glu Ser Pro Ala Thr Ala Ala Glu Thr
        35                  40                  45              
Ala Ser Glu Glu Leu Asp Asn Arg Ser Leu Glu Glu Ile Leu Asn Ser
    50                  55                  60                  
Ile Pro Pro Pro Pro Pro Pro Ala Met Thr Asn Glu Ala Gly Ala Pro
65                  70                  75                  80  
Arg Leu Met Ile Thr His Ile Val Asn Gln Asn Phe Lys Ser Tyr Ala
                85                  90                  95      
Gly Glu Lys Ile Leu Gly Pro Phe His Lys Arg Phe Ser Cys Ile Ile
            100                 105                 110         
Gly Pro Asn Gly Ser Gly Lys Ser Asn Val Ile Asp Ser Met Leu Phe
        115                 120                 125             
Val Phe Gly Tyr Arg Ala Gln Lys Ile Arg Ser Lys Lys Leu Ser Val
    130                 135                 140                 
Leu Ile His Asn Ser Asp Glu His Lys Asp Ile Gln Ser Cys Thr Val
145                 150                 155                 160 
Glu Val His Phe Gln Lys Ile Ile Asp Lys Glu Gly Asp Asp Tyr Glu
                165                 170                 175     
Val Ile Pro Asn Ser Asn Phe Tyr Val Ser Arg Thr Ala Cys Arg Asp
            180                 185                 190         
Asn Thr Ser Val Tyr His Ile Ser Gly Lys Lys Lys Thr Phe Lys Asp
        195                 200                 205             
Val Gly Asn Leu Leu Arg Ser His Gly Ile Asp Leu Asp His Asn Arg
    210                 215                 220                 
Phe Leu Ile Leu Gln Gly Glu Val Glu Gln Ile Ala Met Met Lys Pro
225                 230                 235                 240 
Lys Gly Gln Thr Glu His Asp Glu Gly Met Leu Glu Tyr Leu Glu Asp
                245                 250                 255     
Ile Ile Gly Cys Gly Arg Leu Asn Glu Pro Ile Lys Val Leu Cys Arg
            260                 265                 270         
Arg Val Glu Ile Leu Asn Glu His Arg Gly Glu Lys Leu Asn Arg Val
        275                 280                 285             
Lys Met Val Glu Lys Glu Lys Asp Ala Leu Glu Gly Glu Lys Asn Ile
    290                 295                 300                 
Ala Ile Glu Phe Leu Thr Leu Glu Asn Glu Ile Phe Arg Lys Lys Asn
305                 310                 315                 320 
His Val Cys Gln Tyr Tyr Ile Tyr Glu Leu Gln Lys Arg Ile Ala Glu
                325                 330                 335     
Met Glu Thr Gln Lys Glu Lys Ile His Glu Asp Thr Lys Glu Ile Asn
            340                 345                 350         
Glu Lys Ser Asn Ile Leu Ser Asn Glu Met Lys Ala Lys Asn Lys Asp
        355                 360                 365             
Val Lys Asp Thr Glu Lys Lys Leu Asn Lys Ile Thr Lys Phe Ile Glu
    370                 375                 380                 
Glu Asn Lys Glu Lys Phe Thr Gln Leu Asp Leu Glu Asp Val Gln Val
385                 390                 395                 400 
Arg Glu Lys Leu Lys His Ala Thr Ser Lys Ala Lys Lys Leu Glu Lys
                405                 410                 415     
Gln Leu Gln Lys Asp Lys Glu Lys Val Glu Glu Phe Lys Ser Ile Pro
            420                 425                 430         
Ala Lys Ser Asn Asn Ile Ile Asn Glu Thr Thr Thr Arg Asn Asn Ala
        435                 440                 445             
Leu Glu Lys Glu Lys Glu Lys Glu Glu Lys Lys Leu Lys Glu Val Met
    450                 455                 460                 
Asp Ser Leu Lys Gln Glu Thr Gln Gly Leu Gln Lys Glu Lys Glu Ser
465                 470                 475                 480 
Arg Glu Lys Glu Leu Met Gly Phe Ser Lys Ser Val Asn Glu Ala Arg
                485                 490                 495     
Ser Lys Met Asp Val Ala Gln Ser Glu Leu Asp Ile Tyr Leu Ser Arg
            500                 505                 510         
His Asn Thr Ala Val Ser Gln Leu Thr Lys Ala Lys Glu Ala Leu Ile
        515                 520                 525             
Ala Ala Ser Glu Thr Leu Lys Glu Arg Lys Ala Ala Ile Arg Asp Ile
    530                 535                 540                 
Glu Gly Lys Leu Pro Gln Thr Glu Gln Glu Leu Lys Glu Lys Glu Lys
545                 550                 555                 560 
Glu Leu Gln Lys Leu Thr Gln Glu Glu Thr Asn Phe Lys Ser Leu Val
                565                 570                 575     
His Asp Leu Phe Gln Lys Val Glu Glu Ala Lys Ser Ser Leu Ala Met
            580                 585                 590         
Asn Arg Ser Arg Gly Lys Val Leu Asp Ala Ile Ile Gln Glu Lys Lys
        595                 600                 605             
Ser Gly Arg Ile Pro Gly Ile Tyr Gly Arg Leu Gly Asp Leu Gly Ala
    610                 615                 620                 
Ile Asp Glu Lys Tyr Asp Val Ala Ile Ser Ser Cys Cys His Ala Leu
625                 630                 635                 640 
Asp Tyr Ile Val Val Asp Ser Ile Asp Ile Ala Gln Glu Cys Val Asn
                645                 650                 655     
Phe Leu Lys Arg Gln Asn Ile Gly Val Ala Thr Phe Ile Gly Leu Asp
            660                 665                 670         
Lys Met Ala Val Trp Ala Lys Lys Met Thr Glu Ile Gln Thr Pro Glu
        675                 680                 685             
Asn Thr Pro Arg Leu Phe Asp Leu Val Lys Val Lys Asp Glu Lys Ile
    690                 695                 700                 
Arg Gln Ala Phe Tyr Phe Ala Leu Arg Asp Thr Leu Val Ala Asp Asn
705                 710                 715                 720 
Leu Asp Gln Ala Thr Arg Val Ala Tyr Gln Lys Asp Arg Arg Trp Arg
                725                 730                 735     
Val Val Thr Leu Gln Gly Gln Ile Ile Glu Gln Ser Gly Thr Met Thr
            740                 745                 750         
Gly Gly Gly Ser Lys Val Met Lys Gly Arg Met Gly Ser Ser Leu Val
        755                 760                 765             
Ile Glu Ile Ser Glu Glu Glu Val Asn Lys Met Glu Ser Gln Leu Gln
    770                 775                 780                 
Asn Asp Ser Lys Lys Ala Met Gln Ile Gln Glu Gln Lys Val Gln Leu
785                 790                 795                 800 
Glu Glu Arg Val Val Lys Leu Arg His Ser Glu Arg Glu Met Arg Asn
                805                 810                 815     
Thr Leu Glu Lys Phe Thr Ala Ser Ile Gln Arg Leu Ile Glu Gln Glu
            820                 825                 830         
Glu Tyr Leu Asn Val Gln Val Lys Glu Leu Glu Ala Asn Val Leu Ala
        835                 840                 845             
Thr Ala Pro Asp Lys Lys Lys Gln Lys Leu Leu Glu Glu Asn Val Ser
    850                 855                 860                 
Ala Phe Lys Thr Glu Tyr Asp Ala Val Ala Glu Lys Ala Gly Lys Val
865                 870                 875                 880 
Glu Ala Glu Val Lys Arg Leu His Asn Thr Ile Val Glu Ile Asn Asn
                885                 890                 895     
His Lys Leu Lys Ala Gln Gln Asp Lys Leu Asp Lys Ile Asn Lys Gln
            900                 905                 910         
Leu Asp Glu Cys Ala Ser Ala Ile Thr Lys Ala Gln Val Ala Ile Lys
        915                 920                 925             
Thr Ala Asp Arg Asn Leu Gln Lys Ala Gln Asp Ser Val Leu Arg Thr
    930                 935                 940                 
Glu Lys Glu Ile Lys Asp Thr Glu Lys Glu Val Asp Asp Leu Thr Ala
945                 950                 955                 960 
Glu Leu Lys Ser Leu Glu Asp Lys Ala Ala Glu Val Val Lys Asn Thr
                965                 970                 975     
Asn Ala Ala Glu Ile Ser Lys Ile Ser Leu His Pro Ile Glu Asp Asn
            980                 985                 990         
Pro Ile Glu Glu Ile Ser Val Leu Ser Pro Glu Asp Leu Glu Ala Ile
        995                 1000                1005            
Lys Asn Pro Asp Ser Ile Thr Asn Gln Ile Ala Leu Leu Glu Ala Arg
    1010                1015                1020                
Cys His Glu Met Lys Pro Asn Leu Gly Ala Ile Ala Glu Tyr Lys Lys
1025                1030                1035                1040
Lys Glu Glu Leu Tyr Leu Gln Arg Val Ala Glu Leu Asp Lys Ile Thr
                1045                1050                1055    
Tyr Glu Arg Asp Ser Phe Arg Gln Ala Tyr Glu Asp Leu Arg Lys Gln
            1060                1065                1070        
Arg Leu Asn Glu Phe Met Ala Gly Phe Tyr Ile Ile Thr Asn Lys Leu
        1075                1080                1085            
Lys Glu Asn Tyr Gln Met Leu Thr Leu Gly Gly Asp Ala Glu Leu Glu
    1090                1095                1100                
Leu Val Asp Ser Leu Asp Pro Phe Ser Glu Gly Ile Met Phe Ser Val
1105                1110                1115                1120
Arg Pro Pro Lys Lys Ser Trp Lys Lys Ile Phe Asn Leu Ser Gly Gly
                1125                1130                1135    
Glu Lys Thr Leu Ser Ser Leu Ala Leu Val Phe Ala Leu His His Tyr
            1140                1145                1150        
Lys Pro Thr Pro Leu Tyr Phe Met Asp Glu Ile Asp Ala Ala Leu Asp
        1155                1160                1165            
Phe Lys Asn Val Ser Ile Val Ala Phe Tyr Ile Tyr Glu Gln Thr Lys
    1170                1175                1180                
Asn Ala Gln Phe Ile Ile Ile Ser Leu Arg Asn Asn Met Phe Glu Ile
1185                1190                1195                1200
Ser Asp Arg Leu Ile Gly Ile Tyr Lys Thr Tyr Asn Ile Thr Lys Ser
                1205                1210                1215    
Val Ala Val Asn Pro Lys Glu Ile Ala Ser Lys Gly Leu Cys
            1220                1225                1230


<210> 7612
<211> 768
<212> PRT
<213> Homo sapiens

<400> 7612
Met Ser Asn Leu Ser Lys Gly Thr Gly Ser Arg Lys Asp Thr Lys Met
 1               5                  10                  15      
Arg Ile Arg Ala Phe Pro Met Thr Met Asp Glu Lys Tyr Val Asn Ser
            20                  25                  30          
Ile Trp Asp Leu Leu Lys Asn Ala Ile Gln Glu Ile Gln Arg Lys Asn
        35                  40                  45              
Asn Ser Gly Leu Ser Phe Glu Glu Leu Tyr Arg Asn Ala Tyr Thr Met
    50                  55                  60                  
Val Leu His Lys His Gly Glu Lys Leu Tyr Thr Gly Leu Arg Glu Val
65                  70                  75                  80  
Val Thr Glu His Leu Ile Asn Lys Val Arg Glu Asp Val Leu Asn Ser
                85                  90                  95      
Leu Asn Asn Asn Phe Leu Gln Thr Leu Asn Gln Ala Trp Asn Asp His
            100                 105                 110         
Gln Thr Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg
        115                 120                 125             
Val Tyr Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu
    130                 135                 140                 
Ile Ile Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His
145                 150                 155                 160 
Leu Arg Gln Thr Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu
                165                 170                 175     
Val Val Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile
            180                 185                 190         
Leu Gly Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro
        195                 200                 205             
Phe Leu Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe
    210                 215                 220                 
Leu Ala Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg
225                 230                 235                 240 
Ile Asn Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Thr
                245                 250                 255     
Glu Glu Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His
            260                 265                 270         
Met Lys Thr Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu
        275                 280                 285             
Lys Asn Gly Lys Thr Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser
    290                 295                 300                 
Arg Val Pro Asn Gly Leu Lys Thr Met Cys Glu Cys Met Ser Ser Tyr
305                 310                 315                 320 
Leu Arg Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys
                325                 330                 335     
Asn Pro Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe
            340                 345                 350         
Asp Arg Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln
        355                 360                 365             
Thr Ile Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser
    370                 375                 380                 
Pro Glu Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val
385                 390                 395                 400 
Lys Gly Leu Thr Glu Gln Glu Val Glu Thr Ile Leu Asp Lys Ala Met
                405                 410                 415     
Val Leu Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr
            420                 425                 430         
Lys Gln His Leu Ala Arg Arg Leu Leu Thr Asn Lys Ser Val Ser Asp
        435                 440                 445             
Asp Ser Glu Lys Asn Met Ile Ser Lys Leu Lys Thr Glu Cys Gly Cys
    450                 455                 460                 
Gln Phe Thr Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser
465                 470                 475                 480 
Asn Thr Thr Met Asp Glu Phe Arg Gln His Leu Gln Ala Thr Gly Val
                485                 490                 495     
Ser Leu Gly Gly Val Asp Leu Thr Val Arg Val Leu Thr Thr Gly Tyr
            500                 505                 510         
Trp Pro Thr Gln Ser Ala Thr Pro Lys Cys Asn Ile Pro Pro Ala Pro
        515                 520                 525             
Arg His Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser
    530                 535                 540                 
Gly Arg Gln Leu Thr Leu Gln His His Met Gly Ser Ala Asp Leu Asn
545                 550                 555                 560 
Ala Thr Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly
                565                 570                 575     
Val Gly Gly Ala Gln Val Thr Gly Ser Asn Thr Arg Lys His Ile Leu
            580                 585                 590         
Gln Val Ser Thr Phe Gln Met Thr Ile Leu Met Leu Phe Asn Asn Arg
        595                 600                 605             
Glu Lys Tyr Thr Phe Glu Glu Ile Gln Gln Glu Thr Asp Ile Pro Glu
    610                 615                 620                 
Arg Glu Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Thr
625                 630                 635                 640 
Gln Arg Val Leu Thr Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly
                645                 650                 655     
His Ile Phe Thr Val Asn Asp Gln Phe Thr Ser Lys Leu His Arg Val
            660                 665                 670         
Lys Ile Gln Thr Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg
        675                 680                 685             
Lys Glu Thr Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu
    690                 695                 700                 
Ala Ala Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn
705                 710                 715                 720 
Val Leu Val Ala Glu Val Thr Gln Gln Leu Lys Ala Arg Phe Leu Pro
                725                 730                 735     
Ser Pro Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu
            740                 745                 750         
Tyr Leu Ala Arg Thr Pro Glu Asp Arg Lys Val Tyr Thr Tyr Val Ala
        755                 760                 765             


<210> 7613
<211> 744
<212> PRT
<213> Homo sapiens

<400> 7613
Met Asp Glu Lys Tyr Val Asn Ser Ile Trp Asp Leu Leu Lys Asn Ala
 1               5                  10                  15      
Ile Gln Glu Ile Gln Arg Lys Asn Asn Ser Gly Leu Ser Phe Glu Glu
            20                  25                  30          
Leu Tyr Arg Asn Ala Tyr Thr Met Val Leu His Lys His Gly Glu Lys
        35                  40                  45              
Leu Tyr Thr Gly Leu Arg Glu Val Val Thr Glu His Leu Ile Asn Lys
    50                  55                  60                  
Val Arg Glu Asp Val Leu Asn Ser Leu Asn Asn Asn Phe Leu Gln Thr
65                  70                  75                  80  
Leu Asn Gln Ala Trp Asn Asp His Gln Thr Ala Met Val Met Ile Arg
                85                  90                  95      
Asp Ile Leu Met Tyr Met Asp Arg Val Tyr Val Gln Gln Asn Asn Val
            100                 105                 110         
Glu Asn Val Tyr Asn Leu Gly Leu Ile Ile Phe Arg Asp Gln Val Val
        115                 120                 125             
Arg Tyr Gly Cys Ile Arg Asp His Leu Arg Gln Thr Leu Leu Asp Met
    130                 135                 140                 
Ile Ala Arg Glu Arg Lys Gly Glu Val Val Asp Arg Gly Ala Ile Arg
145                 150                 155                 160 
Asn Ala Cys Gln Met Leu Met Ile Leu Gly Leu Glu Gly Arg Ser Val
                165                 170                 175     
Tyr Glu Glu Asp Phe Glu Ala Pro Phe Leu Glu Met Ser Ala Glu Phe
            180                 185                 190         
Phe Gln Met Glu Ser Gln Lys Phe Leu Ala Glu Asn Ser Ala Ser Val
        195                 200                 205             
Tyr Ile Lys Lys Val Glu Ala Arg Ile Asn Glu Glu Ile Glu Arg Val
    210                 215                 220                 
Met His Cys Leu Asp Lys Ser Thr Glu Glu Pro Ile Val Lys Val Val
225                 230                 235                 240 
Glu Arg Glu Leu Ile Ser Lys His Met Lys Thr Ile Val Glu Met Glu
                245                 250                 255     
Asn Ser Gly Leu Val His Met Leu Lys Asn Gly Lys Thr Glu Asp Leu
            260                 265                 270         
Gly Cys Met Tyr Lys Leu Phe Ser Arg Val Pro Asn Gly Leu Lys Thr
        275                 280                 285             
Met Cys Glu Cys Met Ser Ser Tyr Leu Arg Glu Gln Gly Lys Ala Leu
    290                 295                 300                 
Val Ser Glu Glu Gly Glu Gly Lys Asn Pro Val Asp Tyr Ile Gln Gly
305                 310                 315                 320 
Leu Leu Asp Leu Lys Ser Arg Phe Asp Arg Phe Leu Leu Glu Ser Phe
                325                 330                 335     
Asn Asn Asp Arg Leu Phe Lys Gln Thr Ile Ala Gly Asp Phe Glu Tyr
            340                 345                 350         
Phe Leu Asn Leu Asn Ser Arg Ser Pro Glu Tyr Leu Ser Leu Phe Ile
        355                 360                 365             
Asp Asp Lys Leu Lys Lys Gly Val Lys Gly Leu Thr Glu Gln Glu Val
    370                 375                 380                 
Glu Thr Ile Leu Asp Lys Ala Met Val Leu Phe Arg Phe Met Gln Glu
385                 390                 395                 400 
Lys Asp Val Phe Glu Arg Tyr Tyr Lys Gln His Leu Ala Arg Arg Leu
                405                 410                 415     
Leu Thr Asn Lys Ser Val Ser Asp Asp Ser Glu Lys Asn Met Ile Ser
            420                 425                 430         
Lys Leu Lys Thr Glu Cys Gly Cys Gln Phe Thr Ser Lys Leu Glu Gly
        435                 440                 445             
Met Phe Arg Asp Met Ser Ile Ser Asn Thr Thr Met Asp Glu Phe Arg
    450                 455                 460                 
Gln His Leu Gln Ala Thr Gly Val Ser Leu Gly Gly Val Asp Leu Thr
465                 470                 475                 480 
Val Arg Val Leu Thr Thr Gly Tyr Trp Pro Thr Gln Ser Ala Thr Pro
                485                 490                 495     
Lys Cys Asn Ile Pro Pro Ala Pro Arg His Ala Phe Glu Ile Phe Arg
            500                 505                 510         
Arg Phe Tyr Leu Ala Lys His Ser Gly Arg Gln Leu Thr Leu Gln His
        515                 520                 525             
His Met Gly Ser Ala Asp Leu Asn Ala Thr Phe Tyr Gly Pro Val Lys
    530                 535                 540                 
Lys Glu Asp Gly Ser Glu Val Gly Val Gly Gly Ala Gln Val Thr Gly
545                 550                 555                 560 
Ser Asn Thr Arg Lys His Ile Leu Gln Val Ser Thr Phe Gln Met Thr
                565                 570                 575     
Ile Leu Met Leu Phe Asn Asn Arg Glu Lys Tyr Thr Phe Glu Glu Ile
            580                 585                 590         
Gln Gln Glu Thr Asp Ile Pro Glu Arg Glu Leu Val Arg Ala Leu Gln
        595                 600                 605             
Ser Leu Ala Cys Gly Lys Pro Thr Gln Arg Val Leu Thr Lys Glu Pro
    610                 615                 620                 
Lys Ser Lys Glu Ile Glu Asn Gly His Ile Phe Thr Val Asn Asp Gln
625                 630                 635                 640 
Phe Thr Ser Lys Leu His Arg Val Lys Ile Gln Thr Val Ala Ala Lys
                645                 650                 655     
Gln Gly Glu Ser Asp Pro Glu Arg Lys Glu Thr Arg Gln Lys Val Asp
            660                 665                 670         
Asp Asp Arg Lys His Glu Ile Glu Ala Ala Ile Val Arg Ile Met Lys
        675                 680                 685             
Ser Arg Lys Lys Met Gln His Asn Val Leu Val Ala Glu Val Thr Gln
    690                 695                 700                 
Gln Leu Lys Ala Arg Phe Leu Pro Ser Pro Val Val Ile Lys Lys Arg
705                 710                 715                 720 
Ile Glu Gly Leu Ile Glu Arg Glu Tyr Leu Ala Arg Thr Pro Glu Asp
                725                 730                 735     
Arg Lys Val Tyr Thr Tyr Val Ala
            740                 


<210> 7614
<211> 702
<212> PRT
<213> Homo sapiens

<400> 7614
Met Ser Asn Leu Ser Lys Gly Thr Gly Ser Arg Lys Asp Thr Lys Met
 1               5                  10                  15      
Arg Ile Arg Ala Phe Pro Val Arg Glu Asp Val Leu Asn Ser Leu Asn
            20                  25                  30          
Asn Asn Phe Leu Gln Thr Leu Asn Gln Ala Trp Asn Asp His Gln Thr
        35                  40                  45              
Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg Val Tyr
    50                  55                  60                  
Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu Ile Ile
65                  70                  75                  80  
Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His Leu Arg
                85                  90                  95      
Gln Thr Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu Val Val
            100                 105                 110         
Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile Leu Gly
        115                 120                 125             
Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro Phe Leu
    130                 135                 140                 
Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe Leu Ala
145                 150                 155                 160 
Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg Ile Asn
                165                 170                 175     
Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Thr Glu Glu
            180                 185                 190         
Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His Met Lys
        195                 200                 205             
Thr Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu Lys Asn
    210                 215                 220                 
Gly Lys Thr Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser Arg Val
225                 230                 235                 240 
Pro Asn Gly Leu Lys Thr Met Cys Glu Cys Met Ser Ser Tyr Leu Arg
                245                 250                 255     
Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys Asn Pro
            260                 265                 270         
Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe Asp Arg
        275                 280                 285             
Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln Thr Ile
    290                 295                 300                 
Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser Pro Glu
305                 310                 315                 320 
Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val Lys Gly
                325                 330                 335     
Leu Thr Glu Gln Glu Val Glu Thr Ile Leu Asp Lys Ala Met Val Leu
            340                 345                 350         
Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr Lys Gln
        355                 360                 365             
His Leu Ala Arg Arg Leu Leu Thr Asn Lys Ser Val Ser Asp Asp Ser
    370                 375                 380                 
Glu Lys Asn Met Ile Ser Lys Leu Lys Thr Glu Cys Gly Cys Gln Phe
385                 390                 395                 400 
Thr Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser Asn Thr
                405                 410                 415     
Thr Met Asp Glu Phe Arg Gln His Leu Gln Ala Thr Gly Val Ser Leu
            420                 425                 430         
Gly Gly Val Asp Leu Thr Val Arg Val Leu Thr Thr Gly Tyr Trp Pro
        435                 440                 445             
Thr Gln Ser Ala Thr Pro Lys Cys Asn Ile Pro Pro Ala Pro Arg His
    450                 455                 460                 
Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser Gly Arg
465                 470                 475                 480 
Gln Leu Thr Leu Gln His His Met Gly Ser Ala Asp Leu Asn Ala Thr
                485                 490                 495     
Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly Val Gly
            500                 505                 510         
Gly Ala Gln Val Thr Gly Ser Asn Thr Arg Lys His Ile Leu Gln Val
        515                 520                 525             
Ser Thr Phe Gln Met Thr Ile Leu Met Leu Phe Asn Asn Arg Glu Lys
    530                 535                 540                 
Tyr Thr Phe Glu Glu Ile Gln Gln Glu Thr Asp Ile Pro Glu Arg Glu
545                 550                 555                 560 
Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Thr Gln Arg
                565                 570                 575     
Val Leu Thr Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly His Ile
            580                 585                 590         
Phe Thr Val Asn Asp Gln Phe Thr Ser Lys Leu His Arg Val Lys Ile
        595                 600                 605             
Gln Thr Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg Lys Glu
    610                 615                 620                 
Thr Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu Ala Ala
625                 630                 635                 640 
Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn Val Leu
                645                 650                 655     
Val Ala Glu Val Thr Gln Gln Leu Lys Ala Arg Phe Leu Pro Ser Pro
            660                 665                 670         
Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu Tyr Leu
        675                 680                 685             
Ala Arg Thr Pro Glu Asp Arg Lys Val Tyr Thr Tyr Val Ala
    690                 695                 700         


<210> 7615
<211> 1550
<212> PRT
<213> Homo sapiens

<400> 7615
Ala Pro Asp Pro Ser His Arg Pro Ala Ala Ser Ala Ser Pro Asp Ser
 1               5                  10                  15      
Pro Pro Gly Asp Pro Glu Ala Pro Thr Ser Ser Glu Met Ser Arg Asn
            20                  25                  30          
Asp Lys Glu Pro Phe Phe Val Lys Phe Leu Lys Ser Ser Asp Asn Ser
        35                  40                  45              
Lys Cys Phe Phe Lys Ala Leu Glu Ser Ile Lys Glu Phe Gln Ser Glu
    50                  55                  60                  
Glu Tyr Leu Gln Ile Ile Thr Glu Glu Glu Ala Leu Lys Ile Lys Glu
65                  70                  75                  80  
Asn Asp Arg Ser Leu Tyr Ile Cys Asp Pro Phe Ser Gly Val Val Phe
                85                  90                  95      
Asp His Leu Lys Lys Leu Gly Cys Arg Ile Val Gly Pro Gln Val Val
            100                 105                 110         
Ile Phe Cys Met His His Gln Arg Cys Val Pro Arg Ala Glu His Pro
        115                 120                 125             
Val Tyr Asn Met Val Met Ser Asp Val Thr Ile Ser Cys Thr Ser Leu
    130                 135                 140                 
Glu Lys Glu Lys Arg Glu Glu Val His Lys Tyr Val Gln Met Met Gly
145                 150                 155                 160 
Gly Arg Val Tyr Arg Asp Leu Asn Val Ser Val Thr His Leu Ile Ala
                165                 170                 175     
Gly Glu Val Gly Ser Lys Lys Tyr Leu Val Ala Ala Asn Leu Lys Lys
            180                 185                 190         
Pro Ile Leu Leu Pro Ser Trp Ile Lys Thr Leu Trp Glu Lys Ser Gln
        195                 200                 205             
Glu Lys Lys Ile Thr Arg Tyr Thr Asp Ile Asn Met Glu Asp Phe Lys
    210                 215                 220                 
Cys Pro Ile Phe Leu Gly Cys Ile Ile Cys Val Thr Gly Leu Cys Gly
225                 230                 235                 240 
Leu Asp Arg Lys Glu Val Gln Gln Leu Thr Val Lys His Gly Gly Gln
                245                 250                 255     
Tyr Met Gly Gln Leu Lys Met Asn Glu Cys Thr His Leu Ile Val Gln
            260                 265                 270         
Glu Pro Lys Gly Gln Lys Tyr Glu Cys Ala Lys Arg Trp Asn Val His
        275                 280                 285             
Cys Val Thr Thr Gln Trp Phe Phe Asp Ser Ile Glu Lys Gly Phe Cys
    290                 295                 300                 
Gln Asp Glu Ser Ile Tyr Lys Thr Glu Pro Arg Pro Glu Ala Lys Thr
305                 310                 315                 320 
Met Pro Asn Ser Ser Thr Pro Thr Ser Gln Ile Asn Thr Ile Asp Ser
                325                 330                 335     
Arg Thr Leu Ser Asp Val Ser Asn Ile Ser Asn Ile Asn Ala Ser Cys
            340                 345                 350         
Val Ser Glu Ser Ile Cys Asn Ser Leu Asn Ser Lys Leu Glu Pro Thr
        355                 360                 365             
Leu Glu Asn Leu Glu Asn Leu Asp Val Ser Ala Phe Gln Ala Pro Glu
    370                 375                 380                 
Asp Leu Leu Asp Gly Cys Arg Ile Tyr Leu Cys Gly Phe Ser Gly Arg
385                 390                 395                 400 
Lys Leu Asp Lys Leu Arg Arg Leu Ile Asn Ser Gly Gly Gly Val Arg
                405                 410                 415     
Phe Asn Gln Leu Asn Glu Asp Val Thr His Val Ile Val Gly Asp Tyr
            420                 425                 430         
Asp Asp Glu Leu Lys Gln Phe Trp Asn Lys Ser Ala His Arg Pro His
        435                 440                 445             
Val Val Gly Ala Lys Trp Leu Leu Glu Cys Phe Ser Lys Gly Tyr Met
    450                 455                 460                 
Leu Ser Glu Glu Pro Tyr Ile His Ala Asn Tyr Gln Pro Val Glu Ile
465                 470                 475                 480 
Pro Val Ser His Gln Pro Glu Ser Lys Ala Ala Leu Leu Lys Lys Lys
                485                 490                 495     
Asn Ser Ser Phe Ser Lys Lys Asp Phe Ala Pro Ser Glu Lys His Glu
            500                 505                 510         
Gln Ala Asp Glu Asp Leu Leu Ser Gln Tyr Glu Asn Gly Ser Ser Thr
        515                 520                 525             
Val Val Glu Ala Lys Thr Ser Glu Ala Arg Pro Phe Asn Asp Ser Thr
    530                 535                 540                 
His Ala Glu Pro Leu Asn Asp Ser Thr His Ile Ser Leu Gln Glu Glu
545                 550                 555                 560 
Asn Gln Ser Ser Val Ser His Cys Val Pro Asp Val Ser Thr Ile Thr
                565                 570                 575     
Glu Glu Gly Leu Phe Ser Gln Lys Ser Phe Leu Val Leu Gly Phe Ser
            580                 585                 590         
Asn Glu Asn Glu Ser Asn Ile Ala Asn Ile Ile Lys Glu Asn Ala Gly
        595                 600                 605             
Lys Ile Met Ser Leu Leu Ser Arg Thr Val Ala Asp Tyr Ala Val Val
    610                 615                 620                 
Pro Leu Leu Gly Cys Glu Val Glu Ala Thr Val Gly Glu Val Val Thr
625                 630                 635                 640 
Asn Thr Trp Leu Val Thr Cys Ile Asp Tyr Gln Thr Leu Phe Asp Pro
                645                 650                 655     
Lys Ser Asn Pro Leu Phe Thr Pro Val Pro Val Met Thr Gly Met Thr
            660                 665                 670         
Pro Leu Glu Asp Cys Val Ile Ser Phe Ser Gln Cys Ala Gly Ala Glu
        675                 680                 685             
Lys Glu Ser Leu Thr Phe Leu Ala Asn Leu Leu Gly Ala Ser Val Gln
    690                 695                 700                 
Glu Tyr Phe Val Arg Lys Ser Asn Ala Lys Lys Gly Met Phe Ala Ser
705                 710                 715                 720 
Thr His Leu Ile Leu Lys Glu Arg Gly Gly Ser Lys Tyr Glu Ala Ala
                725                 730                 735     
Lys Lys Trp Asn Leu Pro Ala Val Thr Ile Ala Trp Leu Leu Glu Thr
            740                 745                 750         
Ala Arg Thr Gly Lys Arg Ala Asp Glu Ser His Phe Leu Ile Glu Asn
        755                 760                 765             
Ser Thr Lys Glu Glu Arg Ser Leu Glu Thr Glu Ile Thr Asn Gly Ile
    770                 775                 780                 
Asn Leu Asn Ser Asp Thr Ala Glu His Pro Gly Thr Arg Leu Gln Thr
785                 790                 795                 800 
His Arg Lys Thr Val Val Thr Pro Leu Asp Met Asn Arg Phe Gln Ser
                805                 810                 815     
Lys Ala Phe Arg Ala Val Val Ser Gln His Ala Arg Gln Val Ala Ala
            820                 825                 830         
Ser Pro Ala Val Gly Gln Pro Leu Gln Lys Glu Pro Ser Leu His Leu
        835                 840                 845             
Asp Thr Pro Ser Lys Phe Leu Ser Lys Asp Lys Leu Phe Lys Pro Ser
    850                 855                 860                 
Phe Asp Val Lys Asp Ala Leu Ala Ala Leu Glu Thr Pro Gly Arg Pro
865                 870                 875                 880 
Ser Gln Gln Lys Arg Lys Pro Ser Thr Pro Leu Ser Glu Val Ile Val
                885                 890                 895     
Lys Asn Leu Gln Leu Ala Leu Ala Asn Ser Ser Arg Asn Ala Val Ala
            900                 905                 910         
Leu Ser Ala Ser Pro Gln Leu Lys Glu Ala Gln Ser Glu Lys Glu Glu
        915                 920                 925             
Ala Pro Lys Pro Leu His Lys Val Val Val Cys Val Ser Lys Lys Leu
    930                 935                 940                 
Ser Lys Lys Gln Ser Glu Leu Asn Gly Ile Ala Ala Ser Leu Gly Ala
945                 950                 955                 960 
Asp Tyr Arg Trp Ser Phe Asp Glu Thr Val Thr His Phe Ile Tyr Gln
                965                 970                 975     
Gly Arg Pro Asn Asp Thr Asn Arg Glu Tyr Lys Ser Val Lys Glu Arg
            980                 985                 990         
Gly Val His Ile Val Ser Glu His Trp Leu Leu Asp Cys Ala Gln Glu
        995                 1000                1005            
Cys Lys His Leu Pro Glu Ser Leu Tyr Pro His Thr Tyr Asn Pro Lys
    1010                1015                1020                
Met Ser Leu Asp Ile Ser Ala Val Gln Asp Gly Arg Leu Cys Asn Ser
1025                1030                1035                1040
Arg Leu Leu Ser Ala Val Ser Ser Thr Lys Asp Asp Glu Pro Asp Pro
                1045                1050                1055    
Leu Ile Leu Glu Glu Asn Asp Val Asp Asn Met Ala Thr Asn Asn Lys
            1060                1065                1070        
Glu Ser Ala Pro Ser Asn Gly Ser Gly Lys Asn Asp Ser Lys Gly Val
        1075                1080                1085            
Leu Thr Gln Thr Leu Glu Met Arg Glu Asn Phe Gln Lys Gln Leu Gln
    1090                1095                1100                
Glu Ile Met Ser Ala Thr Ser Ile Val Lys Pro Gln Gly Gln Arg Thr
1105                1110                1115                1120
Ser Leu Ser Arg Ser Gly Cys Asn Ser Ala Ser Ser Thr Pro Asp Ser
                1125                1130                1135    
Thr Arg Ser Ala Arg Ser Gly Arg Ser Arg Val Leu Glu Ala Leu Arg
            1140                1145                1150        
Gln Ser Arg Gln Thr Val Pro Asp Val Asn Thr Glu Pro Ser Gln Asn
        1155                1160                1165            
Glu Gln Ile Ile Trp Asp Asp Pro Thr Ala Arg Glu Glu Arg Ala Arg
    1170                1175                1180                
Leu Ala Ser Asn Leu Gln Trp Pro Ser Cys Pro Thr Gln Tyr Ser Glu
1185                1190                1195                1200
Leu Gln Val Asp Ile Gln Asn Leu Glu Asp Ser Pro Phe Gln Lys Pro
                1205                1210                1215    
Leu His Asp Ser Glu Ile Ala Lys Gln Ala Val Cys Asp Pro Gly Asn
            1220                1225                1230        
Ile Arg Val Thr Glu Ala Pro Lys His Pro Ile Ser Glu Glu Leu Glu
        1235                1240                1245            
Thr Pro Ile Lys Asp Ser His Leu Ile Pro Thr Pro Gln Ala Pro Ser
    1250                1255                1260                
Ile Ala Phe Pro Leu Ala Asn Pro Pro Val Ala Pro His Pro Arg Glu
1265                1270                1275                1280
Lys Ile Ile Thr Ile Glu Glu Thr His Glu Glu Leu Lys Lys Gln Tyr
                1285                1290                1295    
Ile Phe Gln Leu Ser Ser Leu Asn Pro Gln Glu Arg Ile Asp Tyr Cys
            1300                1305                1310        
His Leu Ile Glu Lys Leu Gly Gly Leu Val Ile Glu Lys Gln Cys Phe
        1315                1320                1325            
Asp Pro Thr Cys Thr His Ile Val Val Gly His Pro Leu Arg Asn Glu
    1330                1335                1340                
Lys Tyr Leu Ala Ser Val Ala Ala Gly Lys Trp Val Leu His Arg Ser
1345                1350                1355                1360
Tyr Leu Glu Ala Cys Arg Thr Ala Gly His Phe Val Gln Glu Glu Asp
                1365                1370                1375    
Tyr Glu Trp Gly Ser Ser Ser Ile Leu Asp Val Leu Thr Gly Ile Asn
            1380                1385                1390        
Val Gln Gln Arg Arg Leu Ala Leu Ala Ala Met Arg Trp Arg Lys Lys
        1395                1400                1405            
Ile Gln Gln Arg Gln Glu Ser Gly Ile Val Glu Gly Ala Phe Ser Gly
    1410                1415                1420                
Trp Lys Val Ile Leu His Val Asp Gln Ser Arg Glu Ala Gly Phe Lys
1425                1430                1435                1440
Arg Leu Leu Gln Ser Gly Gly Ala Lys Val Leu Pro Gly His Ser Val
                1445                1450                1455    
Pro Leu Phe Lys Glu Ala Thr His Leu Phe Ser Asp Leu Asn Lys Leu
            1460                1465                1470        
Lys Pro Asp Asp Ser Gly Val Asn Ile Ala Glu Ala Ala Ala Gln Asn
        1475                1480                1485            
Val Tyr Cys Leu Arg Thr Glu Tyr Ile Ala Asp Tyr Leu Met Gln Glu
    1490                1495                1500                
Ser Pro Pro His Val Glu Asn Tyr Cys Leu Pro Glu Ala Ile Ser Phe
1505                1510                1515                1520
Ile Gln Asn Asn Lys Glu Leu Gly Thr Gly Leu Ser Gln Lys Arg Lys
                1525                1530                1535    
Ala Pro Thr Glu Lys Asn Lys Ile Lys Arg Pro Arg Val His
            1540                1545                1550


<210> 7616
<211> 383
<212> PRT
<213> Homo sapiens

<400> 7616
Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp
 1               5                  10                  15      
Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu
            20                  25                  30          
Gln Asp Asp Lys Ser Arg Asp Ser Ala Gly Pro Glu Arg Asp Leu Ala
        35                  40                  45              
Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly Ser
    50                  55                  60                  
Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly Glu
65                  70                  75                  80  
Ala Glu Ala Leu Gly Arg Glu His Arg Ala Gln Arg Leu Phe Pro Asp
                85                  90                  95      
Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys Thr
            100                 105                 110         
Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met
        115                 120                 125             
His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro
    130                 135                 140                 
Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser
145                 150                 155                 160 
Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp
                165                 170                 175     
Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser
            180                 185                 190         
Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr
        195                 200                 205             
Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro
    210                 215                 220                 
Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly
225                 230                 235                 240 
Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu
                245                 250                 255     
Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu
            260                 265                 270         
Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala
        275                 280                 285             
Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg
    290                 295                 300                 
Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu
305                 310                 315                 320 
Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser
                325                 330                 335     
Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His
            340                 345                 350         
Gln Glu Ser Thr Thr Glu Thr Asn Trp Pro Arg Glu Leu Lys Asp Gly
        355                 360                 365             
Asn Gly Gln Glu Ser Leu Ser Met Ser Ser Ser Ser Ser Pro Ala
    370                 375                 380             


<210> 7617
<211> 382
<212> PRT
<213> Homo sapiens

<400> 7617
Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp
 1               5                  10                  15      
Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu
            20                  25                  30          
Gln Asp Asp Lys Ser Arg Asp Ser Ala Gly Pro Glu Arg Asp Leu Ala
        35                  40                  45              
Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly Ser
    50                  55                  60                  
Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly Glu
65                  70                  75                  80  
Ala Glu Ala Leu Gly Arg Glu His Arg Ala Gln Arg Leu Phe Pro Asp
                85                  90                  95      
Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys Thr
            100                 105                 110         
Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met
        115                 120                 125             
His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro
    130                 135                 140                 
Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser
145                 150                 155                 160 
Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp
                165                 170                 175     
Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser
            180                 185                 190         
Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr
        195                 200                 205             
Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro
    210                 215                 220                 
Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly
225                 230                 235                 240 
Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu
                245                 250                 255     
Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu
            260                 265                 270         
Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala
        275                 280                 285             
Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg
    290                 295                 300                 
Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu
305                 310                 315                 320 
Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser
                325                 330                 335     
Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His
            340                 345                 350         
Gln Glu Ser Thr Thr Asp Pro Gly Ser Pro Lys Lys Cys Arg Ala Arg
        355                 360                 365             
Phe Gly Leu Asn Gln Gln Thr Asp Trp Cys Gly Pro Cys Arg
    370                 375                 380         


<210> 7618
<211> 383
<212> PRT
<213> Homo sapiens

<400> 7618
Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp
 1               5                  10                  15      
Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu
            20                  25                  30          
Gln Asp Asp Lys Ser Arg Asp Ser Ala Gly Pro Glu Arg Asp Leu Ala
        35                  40                  45              
Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly Ser
    50                  55                  60                  
Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly Glu
65                  70                  75                  80  
Ala Glu Ala Leu Gly Arg Glu His Arg Ala Gln Arg Leu Phe Pro Asp
                85                  90                  95      
Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys Thr
            100                 105                 110         
Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met
        115                 120                 125             
His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro
    130                 135                 140                 
Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser
145                 150                 155                 160 
Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp
                165                 170                 175     
Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser
            180                 185                 190         
Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr
        195                 200                 205             
Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro
    210                 215                 220                 
Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly
225                 230                 235                 240 
Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu
                245                 250                 255     
Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu
            260                 265                 270         
Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala
        275                 280                 285             
Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg
    290                 295                 300                 
Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu
305                 310                 315                 320 
Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser
                325                 330                 335     
Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His
            340                 345                 350         
Gln Glu Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr Pro
        355                 360                 365             
Glu Lys Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu
    370                 375                 380             


<210> 7619
<211> 494
<212> PRT
<213> Homo sapiens

<400> 7619
Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp
 1               5                  10                  15      
Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu
            20                  25                  30          
Gln Asp Asp Lys Ser Arg Asp Ser Ala Gly Pro Glu Arg Asp Leu Ala
        35                  40                  45              
Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly Ser
    50                  55                  60                  
Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly Glu
65                  70                  75                  80  
Ala Glu Ala Leu Gly Arg Glu His Arg Ala Gln Arg Leu Phe Pro Asp
                85                  90                  95      
Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys Thr
            100                 105                 110         
Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met
        115                 120                 125             
His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro
    130                 135                 140                 
Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser
145                 150                 155                 160 
Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp
                165                 170                 175     
Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser
            180                 185                 190         
Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr
        195                 200                 205             
Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro
    210                 215                 220                 
Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly
225                 230                 235                 240 
Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu
                245                 250                 255     
Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu
            260                 265                 270         
Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala
        275                 280                 285             
Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg
    290                 295                 300                 
Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu
305                 310                 315                 320 
Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser
                325                 330                 335     
Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His
            340                 345                 350         
Gln Glu Ser Thr Thr Asp Pro Gly Ser Pro Lys Lys Cys Arg Ala Arg
        355                 360                 365             
Phe Gly Leu Asn Gln Gln Thr Asp Trp Cys Gly Pro Cys Arg Arg Lys
    370                 375                 380                 
Lys Lys Cys Ile Arg Tyr Leu Pro Gly Glu Gly Arg Cys Pro Ser Pro
385                 390                 395                 400 
Val Pro Ser Asp Asp Ser Ala Leu Gly Cys Pro Gly Ser Pro Ala Pro
                405                 410                 415     
Gln Asp Ser Pro Ser Tyr His Leu Leu Pro Arg Phe Pro Thr Glu Leu
            420                 425                 430         
Leu Thr Ser Pro Ala Glu Arg His Leu His Pro Gln Val Ser Pro Leu
        435                 440                 445             
Leu Ser Ala Ser Gln Pro Gln Gly Pro His Arg Pro Pro Ala Ala Pro
    450                 455                 460                 
Cys Arg Ala His Arg Tyr Ser Asn Arg Asn Leu Arg Asp Arg Trp Pro
465                 470                 475                 480 
Ser Arg His Arg Thr Pro Gly Arg Leu Gln Glu Pro Thr Pro
                485                 490                 


<210> 7620
<211> 384
<212> PRT
<213> Homo sapiens

<400> 7620
Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp
 1               5                  10                  15      
Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu
            20                  25                  30          
Gln Asp Asp Lys Ser Arg Asp Ser Ala Ala Gly Pro Glu Arg Asp Leu
        35                  40                  45              
Ala Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly
    50                  55                  60                  
Gly Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly
65                  70                  75                  80  
Glu Ala Glu Ala Leu Gly Arg Glu His Ala Ala Gln Arg Leu Phe Pro
                85                  90                  95      
Asp Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys
            100                 105                 110         
Thr Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu
        115                 120                 125             
Met His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln
    130                 135                 140                 
Pro Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu
145                 150                 155                 160 
Ser Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala
                165                 170                 175     
Asp Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu
            180                 185                 190         
Ser Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His
        195                 200                 205             
Thr Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val
    210                 215                 220                 
Pro Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser
225                 230                 235                 240 
Gly Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala
                245                 250                 255     
Glu Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro
            260                 265                 270         
Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile
        275                 280                 285             
Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly
    290                 295                 300                 
Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu
305                 310                 315                 320 
Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp
                325                 330                 335     
Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys
            340                 345                 350         
His Gln Glu Ser Thr Thr Glu Thr Asn Trp Pro Arg Glu Leu Lys Asp
        355                 360                 365             
Gly Asn Gly Gln Glu Ser Leu Ser Met Ser Ser Ser Ser Ser Pro Ala
    370                 375                 380                 


<210> 7621
<211> 384
<212> PRT
<213> Homo sapiens

<400> 7621
Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp
 1               5                  10                  15      
Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu
            20                  25                  30          
Gln Asp Asp Lys Ser Arg Asp Ser Ala Ala Gly Pro Glu Arg Asp Leu
        35                  40                  45              
Ala Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly
    50                  55                  60                  
Gly Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly
65                  70                  75                  80  
Glu Ala Glu Ala Leu Gly Arg Glu His Ala Ala Gln Arg Leu Phe Pro
                85                  90                  95      
Asp Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys
            100                 105                 110         
Thr Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu
        115                 120                 125             
Met His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln
    130                 135                 140                 
Pro Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu
145                 150                 155                 160 
Ser Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala
                165                 170                 175     
Asp Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu
            180                 185                 190         
Ser Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His
        195                 200                 205             
Thr Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val
    210                 215                 220                 
Pro Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser
225                 230                 235                 240 
Gly Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala
                245                 250                 255     
Glu Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro
            260                 265                 270         
Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile
        275                 280                 285             
Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly
    290                 295                 300                 
Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu
305                 310                 315                 320 
Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp
                325                 330                 335     
Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys
            340                 345                 350         
His Gln Glu Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr
        355                 360                 365             
Pro Glu Lys Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu
    370                 375                 380                 


<210> 7622
<211> 669
<212> PRT
<213> Homo sapiens

<400> 7622
Met Gly Ser Asn Ser Ser Arg Ile Gly Asp Leu Pro Lys Asn Glu Tyr
 1               5                  10                  15      
Leu Lys Lys Leu Ser Gly Thr Glu Ser Ile Ser Glu Asn Asp Pro Phe
            20                  25                  30          
Trp Asn Gln Leu Leu Ser Phe Ser Phe Pro Ala Pro Thr Ser Ser Ser
        35                  40                  45              
Glu Leu Lys Leu Leu Glu Glu Ala Thr Ile Ser Val Cys Arg Ser Leu
    50                  55                  60                  
Val Lys Asn Asn Pro Arg Thr Gly Asn Leu Gly Ala Leu Ile Lys Val
65                  70                  75                  80  
Phe Leu Ser Arg Thr Lys Glu Leu Lys Leu Ser Ala Glu Cys Gln Asn
                85                  90                  95      
His Ile Phe Ile Trp Gln Thr His Asn Ala Leu Phe Ile Ile Cys Cys
            100                 105                 110         
Leu Leu Lys Val Phe Ile Cys Gln Met Ser Glu Glu Glu Leu Gln Leu
        115                 120                 125             
His Phe Thr Tyr Glu Glu Lys Ser Pro Gly Asn Tyr Ser Ser Asp Ser
    130                 135                 140                 
Glu Asp Leu Leu Glu Glu Leu Leu Cys Cys Leu Met Gln Leu Ile Thr
145                 150                 155                 160 
Asp Ile Pro Leu Leu Asp Ile Thr Tyr Glu Ile Ser Val Glu Ala Ile
                165                 170                 175     
Ser Thr Met Val Val Phe Leu Ser Cys Gln Leu Phe His Lys Glu Val
            180                 185                 190         
Leu Arg Gln Ser Ile Ser His Lys Tyr Leu Met Arg Gly Pro Cys Leu
        195                 200                 205             
Pro Tyr Thr Ser Lys Leu Val Lys Thr Leu Leu Tyr Asn Phe Ile Arg
    210                 215                 220                 
Gln Glu Lys Pro Pro Pro Pro Gly Ala His Val Phe Pro Gln Gln Ser
225                 230                 235                 240 
Asp Gly Gly Gly Leu Leu Tyr Gly Pro Ala Ser Gly Val Ala Thr Gly
                245                 250                 255     
Leu Trp Thr Val Phe Thr Leu Gly Gly Val Gly Ser Lys Ala Ala Ala
            260                 265                 270         
Ser Pro Glu Leu Ser Ser Pro Leu Ala Asn Gln Ser Leu Leu Leu Leu
        275                 280                 285             
Leu Val Leu Ala Asn Leu Thr Asp Ala Ser Asp Ala Pro Asn Pro Tyr
    290                 295                 300                 
Arg Gln Ala Ile Met Ser Phe Lys Asn Thr Gln Asp Ser Ser Pro Phe
305                 310                 315                 320 
Pro Ser Ser Ile Pro His Ala Phe Gln Ile Asn Phe Asn Ser Leu Tyr
                325                 330                 335     
Thr Ala Leu Cys Glu Gln Gln Thr Ser Asp Gln Ala Thr Leu Leu Leu
            340                 345                 350         
Tyr Thr Leu Leu His Gln Asn Ser Asn Ile Arg Thr Tyr Met Leu Ala
        355                 360                 365             
Arg Thr Asp Met Glu Asn Leu Val Leu Pro Ile Leu Glu Ile Leu Tyr
    370                 375                 380                 
His Val Glu Glu Arg Asn Ser His His Val Tyr Met Ala Leu Ile Ile
385                 390                 395                 400 
Leu Leu Ile Leu Thr Glu Asp Asp Gly Phe Asn Arg Ser Ile His Glu
                405                 410                 415     
Val Ile Leu Lys Asn Ile Thr Trp Tyr Ser Glu Arg Val Leu Thr Glu
            420                 425                 430         
Ile Ser Leu Gly Ser Leu Leu Ile Leu Val Val Ile Arg Thr Ile Gln
        435                 440                 445             
Tyr Asn Met Thr Arg Thr Arg Asp Lys Tyr Leu His Thr Asn Cys Leu
    450                 455                 460                 
Ala Ala Leu Ala Asn Met Ser Ala Gln Phe Arg Ser Leu His Gln Tyr
465                 470                 475                 480 
Ala Ala Gln Arg Ile Ile Ser Leu Phe Ser Leu Leu Ser Lys Lys His
                485                 490                 495     
Asn Lys Val Leu Glu Gln Ala Thr Gln Ser Leu Arg Gly Ser Leu Ser
            500                 505                 510         
Ser Asn Asp Val Pro Leu Pro Asp Tyr Ala Gln Asp Leu Asn Val Ile
        515                 520                 525             
Glu Glu Val Ile Arg Met Met Leu Glu Ile Ile Asn Ser Cys Leu Thr
    530                 535                 540                 
Asn Ser Leu His His Asn Pro Asn Leu Val Tyr Ala Leu Leu Tyr Lys
545                 550                 555                 560 
Arg Asp Leu Phe Glu Gln Phe Arg Thr His Pro Ser Phe Gln Asp Ile
                565                 570                 575     
Met Gln Asn Ile Asp Leu Val Ile Ser Phe Phe Ser Ser Arg Leu Leu
            580                 585                 590         
Gln Ala Gly Ala Glu Leu Ser Val Glu Arg Val Leu Glu Ile Ile Lys
        595                 600                 605             
Gln Gly Val Val Ala Leu Pro Lys Asp Arg Leu Lys Lys Phe Pro Glu
    610                 615                 620                 
Leu Lys Phe Lys Tyr Val Glu Glu Glu Gln Pro Glu Glu Phe Phe Ile
625                 630                 635                 640 
Pro Tyr Val Trp Ser Leu Val Tyr Asn Ser Ala Val Gly Leu Tyr Trp
                645                 650                 655     
Asn Pro Gln Asp Ile Gln Leu Phe Thr Met Asp Ser Asp
            660                 665                 


<210> 7623
<211> 149
<212> PRT
<213> Homo sapiens

<400> 7623
Met Ala Asp Gln Leu Thr Glu Glu Gln Val Thr Glu Phe Lys Glu Ala
 1               5                  10                  15      
Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Arg Glu
            20                  25                  30          
Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu
        35                  40                  45              
Leu Arg Asp Met Met Ser Glu Ile Asp Arg Asp Gly Asn Gly Thr Val
    50                  55                  60                  
Asp Phe Pro Glu Phe Leu Gly Met Met Ala Arg Lys Met Lys Asp Thr
65                  70                  75                  80  
Asp Asn Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp
                85                  90                  95      
Gly Asn Gly Phe Val Ser Ala Ala Glu Leu Arg His Val Met Thr Arg
            100                 105                 110         
Leu Gly Glu Lys Leu Ser Asp Glu Glu Val Asp Glu Met Ile Arg Ala
        115                 120                 125             
Ala Asp Thr Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Arg
    130                 135                 140                 
Val Leu Val Ser Lys
145                 


<210> 7624
<211> 811
<212> PRT
<213> Homo sapiens

<400> 7624
Met Ala Leu Pro Gln Ser Glu Asp Ala Met Thr Gly Asp Thr Asp Lys
 1               5                  10                  15      
Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro
            20                  25                  30          
Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu
        35                  40                  45              
Arg Ser Phe Ser Ser Asp Gly Ser Tyr Thr Leu Asn Arg Ser Ser Tyr
    50                  55                  60                  
Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu
65                  70                  75                  80  
Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His
                85                  90                  95      
Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val Pro Ser
            100                 105                 110         
Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly
        115                 120                 125             
Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile Ile Pro
    130                 135                 140                 
Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys
145                 150                 155                 160 
Arg His Lys Leu Ala Asn Pro Pro Pro Met Val Glu Gly Glu Gly Leu
                165                 170                 175     
Ala Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe Leu Gly
            180                 185                 190         
Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly Lys Glu
        195                 200                 205             
Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp Lys Glu
    210                 215                 220                 
His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu Asn Gly
225                 230                 235                 240 
Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys Arg Ile
                245                 250                 255     
Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val Val Ser
            260                 265                 270         
Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly Ile Leu
        275                 280                 285             
Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu Gly Ala
    290                 295                 300                 
Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val Pro Asp
305                 310                 315                 320 
Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser Pro Ile
                325                 330                 335     
Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile Thr Met
            340                 345                 350         
Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn Gly Tyr
        355                 360                 365             
Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile Thr Gly
    370                 375                 380                 
Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Pro Leu
385                 390                 395                 400 
Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser Ala Arg
                405                 410                 415     
Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly Leu Ala
            420                 425                 430         
Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala Lys Phe
        435                 440                 445             
Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu Arg Cys
    450                 455                 460                 
Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln Gln Glu
465                 470                 475                 480 
Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu Glu Gly
                485                 490                 495     
Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu Thr Lys
            500                 505                 510         
Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu Asn Arg
        515                 520                 525             
Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro Cys Gly
    530                 535                 540                 
Arg Leu Ser Phe Leu Lys Glu Pro Lys Thr Thr Lys Gly Leu Pro Gln
545                 550                 555                 560 
Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys Lys Ile
                565                 570                 575     
Glu Lys Thr Asp Gly Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys
            580                 585                 590         
Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser Pro Cys
        595                 600                 605             
Glu Arg Thr Asp Ile Arg Met Ala Ile Val Ala Asp His Leu Gly Leu
    610                 615                 620                 
Ser Trp Thr Glu Leu Ala Arg Glu Leu Asn Phe Ser Val Asp Glu Ile
625                 630                 635                 640 
Asn Gln Ile Arg Val Glu Asn Pro Asn Ser Leu Ile Ser Gln Ser Phe
                645                 650                 655     
Met Phe Leu Lys Lys Trp Val Thr Arg Asp Gly Lys Asn Ala Thr Thr
            660                 665                 670         
Asp Ala Leu Thr Ser Val Leu Thr Lys Ile Asn Arg Ile Asp Ile Val
        675                 680                 685             
Thr Leu Leu Glu Gly Pro Ile Phe Asp Tyr Gly Asn Ile Ser Gly Thr
    690                 695                 700                 
Arg Ser Phe Ala Asp Glu Asn Asn Val Phe His Asp Pro Val Asp Gly
705                 710                 715                 720 
Tyr Pro Ser Leu Gln Val Glu Leu Glu Thr Pro Thr Gly Leu His Tyr
                725                 730                 735     
Thr Pro Pro Thr Pro Phe Gln Gln Asp Asp Tyr Phe Ser Asp Ile Ser
            740                 745                 750         
Ser Ile Glu Ser Pro Leu Arg Thr Pro Ser Arg Leu Ser Asp Gly Leu
        755                 760                 765             
Val Pro Ser Gln Gly Asn Ile Glu His Ser Ala Asp Gly Pro Pro Val
    770                 775                 780                 
Val Thr Ala Glu Asp Ala Ser Leu Glu Asp Ser Lys Leu Glu Asp Ser
785                 790                 795                 800 
Val Pro Leu Thr Glu Met Pro Glu Ala Val Met
                805                 810     


<210> 7625
<211> 4377
<212> PRT
<213> Homo sapiens

<400> 7625
Met Ala His Ala Ala Ser Gln Leu Lys Lys Asn Arg Asp Leu Glu Ile
 1               5                  10                  15      
Asn Ala Glu Glu Glu Pro Glu Lys Lys Arg Lys His Arg Lys Arg Ser
            20                  25                  30          
Arg Asp Arg Lys Lys Lys Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala
        35                  40                  45              
Ala Arg Ala Gly His Leu Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly
    50                  55                  60                  
Val Asp Ile Asn Ile Cys Asn Gln Asn Gly Leu Asn Ala Leu His Leu
65                  70                  75                  80  
Ala Ser Lys Glu Gly His Val Glu Val Val Ser Glu Leu Leu Gln Arg
                85                  90                  95      
Glu Ala Asn Val Asp Ala Ala Thr Lys Lys Gly Asn Thr Ala Leu His
            100                 105                 110         
Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val Thr
        115                 120                 125             
Asn Gly Ala Asn Val Asn Ala Gln Ser Gln Asn Gly Phe Thr Pro Leu
    130                 135                 140                 
Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys Phe Leu Leu
145                 150                 155                 160 
Asp Asn Gly Ala Ser Gln Ser Leu Ala Thr Glu Asp Gly Phe Thr Pro
                165                 170                 175     
Leu Ala Val Ala Leu Gln Gln Gly His Asp Gln Val Val Ser Leu Leu
            180                 185                 190         
Leu Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile
        195                 200                 205             
Ala Ala Arg Lys Asp Asp Thr Lys Ala Ala Ala Leu Leu Leu Gln Asn
    210                 215                 220                 
Asp Asn Asn Ala Asp Val Glu Ser Lys Ser Gly Phe Thr Pro Leu His
225                 230                 235                 240 
Ile Ala Ala His Tyr Gly Asn Ile Asn Val Ala Thr Leu Leu Leu Asn
                245                 250                 255     
Arg Ala Ala Ala Val Asp Phe Thr Ala Arg Asn Asp Ile Thr Pro Leu
            260                 265                 270         
His Val Ala Ser Lys Arg Gly Asn Ala Asn Met Val Lys Leu Leu Leu
        275                 280                 285             
Asp Arg Gly Ala Lys Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro
    290                 295                 300                 
Leu His Cys Gly Ala Arg Ser Gly His Glu Gln Val Val Glu Met Leu
305                 310                 315                 320 
Leu Asp Arg Ala Ala Pro Ile Leu Ser Lys Thr Lys Asn Gly Leu Ser
                325                 330                 335     
Pro Leu His Met Ala Thr Gln Gly Asp His Leu Asn Cys Val Gln Leu
            340                 345                 350         
Leu Leu Gln His Asn Val Pro Val Asp Asp Val Thr Asn Asp Tyr Leu
        355                 360                 365             
Thr Ala Leu His Val Ala Ala His Cys Gly His Tyr Lys Val Ala Lys
    370                 375                 380                 
Val Leu Leu Asp Lys Lys Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly
385                 390                 395                 400 
Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met
                405                 410                 415     
Glu Leu Leu Leu Lys His Gly Ala Ser Ile Gln Ala Val Thr Glu Ser
            420                 425                 430         
Gly Leu Thr Pro Ile His Val Ala Ala Phe Met Gly His Val Asn Ile
        435                 440                 445             
Val Ser Gln Leu Met His His Gly Ala Ser Pro Asn Thr Thr Asn Val
    450                 455                 460                 
Arg Gly Glu Thr Ala Leu His Met Ala Ala Arg Ser Gly Gln Ala Glu
465                 470                 475                 480 
Val Val Arg Tyr Leu Val Gln Asp Gly Ala Gln Val Glu Ala Lys Ala
                485                 490                 495     
Lys Asp Asp Gln Thr Pro Leu His Ile Ser Ala Arg Leu Gly Lys Ala
            500                 505                 510         
Asp Ile Val Gln Gln Leu Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala
        515                 520                 525             
Thr Thr Ser Gly Tyr Thr Pro Leu His Leu Ser Ala Arg Glu Gly His
    530                 535                 540                 
Glu Asp Val Ala Ala Phe Leu Leu Asp His Gly Ala Ser Leu Ser Ile
545                 550                 555                 560 
Thr Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly
                565                 570                 575     
Lys Leu Glu Val Ala Asn Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp
            580                 585                 590         
Ala Ala Gly Lys Ser Gly Leu Thr Pro Leu His Val Ala Ala His Tyr
        595                 600                 605             
Asp Asn Gln Lys Val Ala Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro
    610                 615                 620                 
His Ala Ala Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys
625                 630                 635                 640 
Lys Asn Gln Met Asp Ile Ala Thr Thr Leu Leu Glu Tyr Gly Ala Asp
                645                 650                 655     
Ala Asn Ala Val Thr Arg Gln Gly Ile Ala Ser Val His Leu Ala Ala
            660                 665                 670         
Gln Glu Gly His Val Asp Met Val Ser Leu Leu Leu Gly Arg Asn Ala
        675                 680                 685             
Asn Val Asn Leu Ser Asn Lys Ser Gly Leu Thr Pro Leu His Leu Ala
    690                 695                 700                 
Ala Gln Glu Asp Arg Val Asn Val Ala Glu Val Leu Val Asn Gln Gly
705                 710                 715                 720 
Ala His Val Asp Ala Gln Thr Lys Met Gly Tyr Thr Pro Leu His Val
                725                 730                 735     
Gly Cys His Tyr Gly Asn Ile Lys Ile Val Asn Phe Leu Leu Gln His
            740                 745                 750         
Ser Ala Lys Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His
        755                 760                 765             
Gln Ala Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln
    770                 775                 780                 
Asn Asn Ala Ser Pro Asn Glu Leu Thr Val Asn Gly Asn Thr Ala Leu
785                 790                 795                 800 
Gly Ile Ala Arg Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys
                805                 810                 815     
Ile Val Thr Glu Glu Thr Met Thr Thr Thr Thr Val Thr Glu Lys His
            820                 825                 830         
Lys Met Asn Val Pro Glu Thr Met Asn Glu Val Leu Asp Met Ser Asp
        835                 840                 845             
Asp Glu Val Arg Lys Ala Asn Ala Pro Glu Met Leu Ser Asp Gly Glu
    850                 855                 860                 
Tyr Ile Ser Asp Val Glu Glu Gly Glu Asp Ala Met Thr Gly Asp Thr
865                 870                 875                 880 
Asp Lys Tyr Leu Gly Pro Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser
                885                 890                 895     
Leu Pro Ala Glu Gly Tyr Met Gly Phe Ser Leu Gly Ala Arg Ser Ala
            900                 905                 910         
Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser Tyr Thr Leu Asn Arg Ser
        915                 920                 925             
Ser Tyr Ala Arg Asp Ser Met Met Ile Glu Glu Leu Leu Val Pro Ser
    930                 935                 940                 
Lys Glu Gln His Leu Thr Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu
945                 950                 955                 960 
Arg His Tyr Ser Trp Ala Ala Asp Thr Leu Asp Asn Val Asn Leu Val
                965                 970                 975     
Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala
            980                 985                 990         
Arg Gly Gly Ser Met Arg Gly Ser Arg His His Gly Met Arg Ile Ile
        995                 1000                1005            
Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg Ile Thr Cys Arg Leu
    1010                1015                1020                
Val Lys Arg His Lys Leu Ala Asn Pro Pro Pro His Gly Glu Arg Arg
1025                1030                1035                1040
Gly Ile Ser Ser Arg Leu Val Glu Met Gly Pro Ala Gly Ala Gln Phe
                1045                1050                1055    
Leu Gly Pro Val Ile Val Glu Ile Pro His Phe Gly Ser Met Arg Gly
            1060                1065                1070        
Lys Glu Arg Glu Leu Ile Val Leu Arg Ser Glu Asn Gly Glu Thr Trp
        1075                1080                1085            
Lys Glu His Gln Phe Asp Ser Lys Asn Glu Asp Leu Thr Glu Leu Leu
    1090                1095                1100                
Asn Gly Met Asp Glu Glu Leu Asp Ser Pro Glu Glu Leu Gly Lys Lys
1105                1110                1115                1120
Arg Ile Cys Arg Ile Ile Thr Lys Asp Phe Pro Gln Tyr Phe Ala Val
                1125                1130                1135    
Val Ser Arg Ile Lys Gln Glu Ser Asn Gln Ile Gly Pro Glu Gly Gly
            1140                1145                1150        
Ile Leu Ser Ser Thr Thr Val Pro Leu Val Gln Ala Ser Phe Pro Glu
        1155                1160                1165            
Gly Ala Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro Val
    1170                1175                1180                
Pro Asp Glu Ile Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe Ser
1185                1190                1195                1200
Pro Ile Val Thr Val Glu Pro Arg Arg Arg Lys Phe His Lys Pro Ile
                1205                1210                1215    
Thr Met Thr Ile Pro Val Pro Pro Pro Ser Gly Glu Gly Val Ser Asn
            1220                1225                1230        
Gly Tyr Lys Gly Asp Thr Thr Pro Asn Leu Arg Leu Leu Cys Ser Ile
        1235                1240                1245            
Thr Gly Gly Thr Ser Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr
    1250                1255                1260                
Pro Leu Thr Phe Ile Lys Asp Cys Val Ser Phe Thr Thr Asn Val Ser
1265                1270                1275                1280
Ala Arg Phe Trp Leu Ala Asp Cys His Gln Val Leu Glu Thr Val Gly
                1285                1290                1295    
Leu Ala Thr Gln Leu Tyr Arg Glu Leu Ile Cys Val Pro Tyr Met Ala
            1300                1305                1310        
Lys Phe Val Val Phe Ala Lys Met Asn Asp Pro Val Glu Ser Ser Leu
        1315                1320                1325            
Arg Cys Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln
    1330                1335                1340                
Gln Glu Asn Phe Glu Glu Val Ala Arg Ser Lys Asp Ile Glu Val Leu
1345                1350                1355                1360
Glu Gly Lys Pro Ile Tyr Val Asp Cys Tyr Gly Asn Leu Ala Pro Leu
                1365                1370                1375    
Thr Lys Gly Gly Gln Gln Leu Val Phe Asn Phe Tyr Ser Phe Lys Glu
            1380                1385                1390        
Asn Arg Leu Pro Phe Ser Ile Lys Ile Arg Asp Thr Ser Gln Glu Pro
        1395                1400                1405            
Cys Gly Arg Leu Ser Phe Leu Lys Glu Arg Lys Thr Thr Lys Gly Leu
    1410                1415                1420                
Pro Gln Thr Ala Val Cys Asn Leu Asn Ile Thr Leu Pro Ala His Lys
1425                1430                1435                1440
Lys Glu Thr Glu Ser Asp Gln Asp Asp Glu Ile Glu Lys Thr Asp Arg
                1445                1450                1455    
Arg Gln Ser Phe Ala Ser Leu Ala Leu Arg Lys Arg Tyr Ser Tyr Leu
            1460                1465                1470        
Thr Glu Pro Gly Met Ile Glu Arg Ser Thr Gly Ala Thr Arg Ser Leu
        1475                1480                1485            
Pro Thr Thr Tyr Ser Tyr Lys Pro Phe Phe Ser Thr Arg Pro Tyr Gln
    1490                1495                1500                
Ser Trp Thr Thr Ala Pro Ile Thr Val Pro Gly Pro Ala Lys Ser Gly
1505                1510                1515                1520
Phe Thr Ser Leu Ser Ser Ser Ser Ser Asn Thr Pro Ser Ala Ser Pro
                1525                1530                1535    
Leu Lys Ser Ile Trp Ser Val Ser Thr Pro Ser Pro Ile Lys Ser Thr
            1540                1545                1550        
Leu Gly Ala Ser Thr Thr Ser Ser Val Lys Ser Ile Ser Asp Val Ala
        1555                1560                1565            
Ser Pro Ile Arg Ser Leu Arg Thr Met Ser Ser Pro Ile Lys Thr Val
    1570                1575                1580                
Val Ser Gln Ser Pro Tyr Asn Ile Gln Val Ser Ser Gly Thr Leu Ala
1585                1590                1595                1600
Arg Ala Pro Ala Val Thr Glu Ala Thr Pro Leu Lys Gly Leu Ala Ser
                1605                1610                1615    
Asn Ser Thr Phe Ser Ser Arg Thr Ser Pro Val Thr Thr Ala Gly Ser
            1620                1625                1630        
Leu Leu Glu Arg Ser Ser Ile Thr Met Thr Pro Pro Ala Ser Pro Lys
        1635                1640                1645            
Ser Asn Ile Asn Met Tyr Ser Ser Ser Leu Pro Phe Lys Ser Ile Ile
    1650                1655                1660                
Thr Ser Ala Ala Pro Leu Ile Ser Ser Pro Leu Lys Ser Val Val Ser
1665                1670                1675                1680
Pro Val Lys Ser Arg Val Asp Val Ile Ser Ser Ala Lys Ile Thr Met
                1685                1690                1695    
Ala Ser Ser Leu Ser Ser Pro Val Lys Gln Met Pro Gly His Ala Glu
            1700                1705                1710        
Val Ala Leu Val Asn Gly Ser Ile Ser Pro Leu Lys Tyr Ala Ser Ser
        1715                1720                1725            
Ser Thr Leu Ile Asn Gly Cys Lys Ala Thr Ala Thr Leu Gln Glu Lys
    1730                1735                1740                
Ile Ser Ser Ala Thr Asn Ser Val Ser Ser Val Val Ser Ala Ala Thr
1745                1750                1755                1760
Asp Thr Val Glu Lys Val Phe Ser Thr Thr Thr Ala Met Pro Phe Ser
                1765                1770                1775    
Pro Leu Arg Ser Tyr Val Ser Ala Ala Pro Ser Ala Phe Gln Ser Leu
            1780                1785                1790        
Arg Thr Pro Ser Ala Ser Ala Leu Tyr Thr Ser Leu Gly Ser Ser Ile
        1795                1800                1805            
Ser Ala Thr Thr Ser Ser Val Thr Ser Ser Ile Ile Thr Val Pro Val
    1810                1815                1820                
Tyr Ser Val Val Asn Val Leu Pro Glu Pro Ala Leu Lys Lys Leu Pro
1825                1830                1835                1840
Asp Ser Asn Ser Phe Thr Lys Ser Ala Ala Ala Leu Leu Ser Pro Ile
                1845                1850                1855    
Lys Thr Leu Thr Thr Glu Thr His Pro Gln Pro His Phe Ser Arg Thr
            1860                1865                1870        
Ser Ser Pro Val Lys Ser Ser Leu Phe Leu Ala Pro Ser Ala Leu Lys
        1875                1880                1885            
Leu Ser Thr Pro Ser Ser Leu Ser Ser Ser Gln Glu Ile Leu Lys Asp
    1890                1895                1900                
Val Ala Glu Met Lys Glu Asp Leu Met Arg Met Thr Ala Ile Leu Gln
1905                1910                1915                1920
Thr Asp Val Pro Glu Glu Lys Pro Phe Gln Pro Glu Leu Pro Lys Glu
                1925                1930                1935    
Gly Arg Ile Asp Asp Glu Glu Pro Phe Lys Ile Val Glu Lys Val Lys
            1940                1945                1950        
Glu Asp Leu Val Lys Val Ser Glu Ile Leu Lys Lys Asp Val Cys Val
        1955                1960                1965            
Asp Asn Lys Gly Ser Pro Lys Ser Pro Lys Ser Asp Lys Gly His Ser
    1970                1975                1980                
Pro Glu Asp Asp Trp Ile Glu Phe Ser Ser Glu Glu Ile Arg Glu Ala
1985                1990                1995                2000
Arg Gln Gln Ala Ala Ala Ser Gln Ser Pro Ser Leu Pro Glu Arg Val
                2005                2010                2015    
Gln Val Lys Ala Lys Ala Ala Ser Glu Lys Asp Tyr Asn Leu Thr Lys
            2020                2025                2030        
Val Ile Asp Tyr Leu Thr Asn Asp Ile Gly Ser Ser Ser Leu Thr Asn
        2035                2040                2045            
Leu Lys Tyr Lys Phe Glu Asp Ala Lys Lys Asp Gly Glu Gly Gly Gln
    2050                2055                2060                
Lys Arg Val Leu Lys Pro Ala Ile Ala Leu Gln Glu His Lys Leu Lys
2065                2070                2075                2080
Met Pro Pro Ala Ser Met Arg Thr Ser Thr Ser Glu Lys Glu Leu Cys
                2085                2090                2095    
Lys Met Ala Asp Ser Phe Phe Gly Thr Asp Thr Ile Leu Glu Ser Pro
            2100                2105                2110        
Asp Asp Phe Ser Gln His Asp Gln Asp Lys Ser Pro Leu Ser Asp Ser
        2115                2120                2125            
Gly Phe Glu Thr Arg Ser Glu Lys Thr Pro Ser Ala Pro Gln Ser Ala
    2130                2135                2140                
Glu Thr Thr Gly Pro Lys Pro Leu Phe His Glu Val Pro Ile Pro Pro
2145                2150                2155                2160
Val Ile Thr Glu Thr Arg Thr Glu Val Val His Val Ile Arg Ser Tyr
                2165                2170                2175    
Asp Pro Ser Ala Gly Asp Val Pro Gln Thr Gln Pro Glu Glu Pro Val
            2180                2185                2190        
Ser Pro Lys Pro Ser Pro Thr Phe Met Glu Leu Glu Pro Lys Pro Thr
        2195                2200                2205            
Thr Ser Ser Ile Lys Glu Lys Val Lys Ala Phe Gln Met Lys Ala Ser
    2210                2215                2220                
Ser Glu Glu Asp Asp His Asn Arg Val Leu Ser Lys Gly Met Arg Val
2225                2230                2235                2240
Lys Glu Glu Thr His Ile Thr Thr Thr Thr Arg Met Val Tyr His Ser
                2245                2250                2255    
Pro Pro Gly Gly Glu Gly Ala Ser Glu Arg Ile Glu Glu Thr Met Ser
            2260                2265                2270        
Val His Asp Ile Met Lys Ala Phe Gln Ser Gly Arg Asp Pro Ser Lys
        2275                2280                2285            
Glu Leu Ala Gly Leu Phe Glu His Lys Ser Ala Val Ser Pro Asp Val
    2290                2295                2300                
His Lys Ser Ala Ala Glu Thr Ser Ala Gln His Ala Glu Lys Asp Asn
2305                2310                2315                2320
Gln Met Lys Pro Lys Leu Glu Arg Ile Ile Glu Val His Ile Glu Lys
                2325                2330                2335    
Gly Asn Gln Ala Glu Pro Thr Glu Val Ile Ile Arg Glu Thr Lys Lys
            2340                2345                2350        
His Pro Glu Lys Glu Met Tyr Val Tyr Gln Lys Asp Leu Ser Arg Gly
        2355                2360                2365            
Asp Ile Asn Leu Lys Asp Phe Leu Pro Glu Lys His Asp Ala Phe Pro
    2370                2375                2380                
Cys Ser Glu Glu Gln Gly Gln Gln Glu Glu Glu Glu Leu Thr Ala Glu
2385                2390                2395                2400
Glu Ser Leu Pro Ser Tyr Leu Glu Ser Ser Arg Val Asn Thr Pro Val
                2405                2410                2415    
Ser Gln Glu Glu Asp Ser Arg Pro Ser Ser Ala Gln Leu Ile Ser Asp
            2420                2425                2430        
Asp Ser Tyr Lys Thr Leu Lys Leu Leu Ser Gln His Ser Ile Glu Tyr
        2435                2440                2445            
His Asp Asp Glu Leu Ser Glu Leu Arg Gly Glu Ser Tyr Arg Phe Ala
    2450                2455                2460                
Glu Lys Met Leu Leu Ser Glu Lys Leu Asp Val Ser His Ser Asp Thr
2465                2470                2475                2480
Glu Glu Ser Val Thr Asp His Ala Gly Pro Pro Ser Ser Glu Leu Gln
                2485                2490                2495    
Gly Ser Asp Lys Arg Ser Arg Glu Lys Ile Ala Thr Ala Pro Lys Lys
            2500                2505                2510        
Glu Ile Leu Ser Lys Ile Tyr Lys Asp Val Ser Glu Asn Gly Val Gly
        2515                2520                2525            
Lys Val Ser Lys Asp Glu His Phe Asp Lys Val Thr Val Leu His Tyr
    2530                2535                2540                
Ser Gly Asn Val Ser Ser Pro Lys His Ala Met Trp Met Arg Phe Thr
2545                2550                2555                2560
Glu Asp Arg Leu Asp Arg Gly Arg Glu Lys Leu Ile Tyr Glu Asp Arg
                2565                2570                2575    
Val Asp Arg Thr Val Lys Glu Ala Glu Glu Lys Leu Thr Glu Val Ser
            2580                2585                2590        
Gln Phe Phe Arg Asp Lys Thr Glu Lys Leu Asn Asp Glu Leu Gln Ser
        2595                2600                2605            
Pro Glu Lys Lys Ala Arg Pro Lys Asn Gly Lys Glu Tyr Ser Ser Gln
    2610                2615                2620                
Ser Pro Thr Ser Ser Ser Pro Glu Lys Val Leu Leu Thr Glu Leu Leu
2625                2630                2635                2640
Ala Ser Asn Asp Glu Trp Val Lys Ala Arg Gln His Gly Pro Asp Gly
                2645                2650                2655    
Gln Gly Phe Pro Lys Ala Glu Glu Lys Ala Pro Ser Leu Pro Ser Ser
            2660                2665                2670        
Pro Glu Lys Met Val Leu Ser Gln Gln Thr Glu Asp Ser Lys Ser Thr
        2675                2680                2685            
Val Glu Ala Lys Gly Ser Ile Ser Gln Ser Lys Ala Pro Asp Gly Pro
    2690                2695                2700                
Gln Ser Gly Phe Gln Leu Lys Gln Ser Lys Leu Ser Ser Ile Arg Leu
2705                2710                2715                2720
Lys Phe Glu Gln Gly Thr His Ala Lys Ser Lys Asp Met Ser Gln Glu
                2725                2730                2735    
Asp Arg Lys Ser Asp Gly Gln Ser Arg Ile Pro Val Lys Lys Ile Gln
            2740                2745                2750        
Glu Ser Lys Leu Pro Val Tyr Gln Val Phe Ala Arg Glu Lys Gln Gln
        2755                2760                2765            
Lys Ala Ile Asp Leu Pro Asp Glu Ser Val Ser Val Gln Lys Asp Phe
    2770                2775                2780                
Met Val Leu Lys Thr Lys Asp Glu His Ala Gln Ser Asn Glu Ile Val
2785                2790                2795                2800
Val Asn Asp Ser Gly Ser Asp Asn Val Lys Lys Gln Arg Thr Glu Met
                2805                2810                2815    
Ser Ser Lys Ala Met Pro Asp Ser Phe Ser Glu Gln Gln Ala Lys Asp
            2820                2825                2830        
Leu Ala Cys His Ile Thr Ser Asp Leu Ala Thr Arg Gly Pro Trp Asp
        2835                2840                2845            
Lys Lys Val Phe Arg Thr Trp Glu Ser Ser Gly Ala Thr Asn Asn Lys
    2850                2855                2860                
Ser Gln Lys Glu Lys Leu Ser His Val Leu Val His Asp Val Arg Glu
2865                2870                2875                2880
Asn His Ile Gly His Pro Glu Ser Lys Ser Val Asp Gln Lys Asn Glu
                2885                2890                2895    
Phe Met Ser Val Thr Glu Arg Glu Arg Lys Leu Leu Thr Asn Gly Ser
            2900                2905                2910        
Leu Ser Glu Ile Lys Glu Met Thr Val Lys Ser Pro Ser Lys Lys Val
        2915                2920                2925            
Leu Tyr Arg Glu Tyr Val Val Lys Glu Gly Asp His Pro Gly Gly Leu
    2930                2935                2940                
Leu Asp Gln Pro Ser Arg Arg Ser Glu Ser Ser Ala Val Ser His Ile
2945                2950                2955                2960
Pro Val Arg Val Ala Asp Glu Arg Arg Met Leu Ser Ser Asn Ile Pro
                2965                2970                2975    
Asp Gly Phe Cys Glu Gln Ser Ala Phe Pro Lys His Glu Leu Ser Gln
            2980                2985                2990        
Lys Leu Ser Gln Ser Ser Met Ser Lys Glu Thr Val Glu Thr Gln His
        2995                3000                3005            
Phe Asn Ser Ile Glu Asp Glu Lys Val Thr Tyr Ser Glu Ile Ser Lys
    3010                3015                3020                
Val Ser Lys His Gln Ser Tyr Val Gly Leu Cys Pro Pro Leu Glu Glu
3025                3030                3035                3040
Thr Glu Thr Ser Pro Thr Lys Ser Pro Asp Ser Leu Glu Phe Ser Pro
                3045                3050                3055    
Gly Lys Glu Ser Pro Ser Ser Asp Val Phe Asp His Ser Pro Ile Asp
            3060                3065                3070        
Gly Leu Glu Lys Leu Ala Pro Leu Ala Gln Thr Glu Gly Gly Lys Glu
        3075                3080                3085            
Ile Lys Thr Leu Pro Val Tyr Val Ser Phe Val Gln Val Gly Lys Gln
    3090                3095                3100                
Tyr Glu Lys Glu Ile Gln Gln Gly Gly Val Lys Lys Ile Ile Ser Gln
3105                3110                3115                3120
Glu Cys Lys Thr Val Gln Glu Thr Arg Gly Thr Phe Tyr Thr Thr Arg
                3125                3130                3135    
Gln Gln Lys Gln Pro Pro Ser Pro Gln Gly Ser Pro Glu Asp Asp Thr
            3140                3145                3150        
Leu Glu Gln Val Ser Phe Leu Asp Ser Ser Gly Lys Ser Pro Leu Thr
        3155                3160                3165            
Pro Glu Thr Pro Ser Ser Glu Glu Val Ser Tyr Glu Phe Thr Ser Lys
    3170                3175                3180                
Thr Pro Asp Ser Leu Ile Ala Tyr Ile Pro Gly Lys Pro Ser Pro Ile
3185                3190                3195                3200
Pro Glu Val Ser Glu Glu Ser Glu Glu Glu Glu Gln Ala Lys Ser Thr
                3205                3210                3215    
Ser Leu Lys Gln Thr Thr Val Glu Glu Thr Ala Val Glu Arg Glu Met
            3220                3225                3230        
Pro Asn Asp Val Ser Lys Asp Ser Asn Gln Arg Pro Lys Asn Asn Arg
        3235                3240                3245            
Val Ala Tyr Ile Glu Phe Pro Pro Pro Pro Pro Leu Asp Ala Asp Gln
    3250                3255                3260                
Ile Glu Ser Asp Lys Lys His His Tyr Leu Pro Glu Lys Glu Val Asp
3265                3270                3275                3280
Met Ile Glu Val Asn Leu Gln Asp Glu His Asp Lys Tyr Gln Leu Ala
                3285                3290                3295    
Glu Pro Val Ile Arg Val Gln Pro Pro Ser Pro Val Pro Pro Gly Ala
            3300                3305                3310        
Asp Val Ser Asp Ser Ser Asp Asp Glu Ser Ile Tyr Gln Pro Val Pro
        3315                3320                3325            
Val Lys Lys Tyr Thr Phe Lys Leu Lys Glu Val Asp Asp Glu Gln Lys
    3330                3335                3340                
Glu Lys Pro Lys Ala Ser Ala Glu Lys Ala Ser Asn Gln Lys Glu Leu
3345                3350                3355                3360
Glu Ser Asn Gly Ser Gly Lys Asp Asn Glu Phe Gly Leu Gly Leu Asp
                3365                3370                3375    
Ser Pro Gln Asn Glu Ile Ala Gln Asn Gly Asn Asn Asp Gln Ser Ile
            3380                3385                3390        
Thr Glu Cys Ser Ile Ala Thr Thr Ala Glu Phe Ser His Asp Thr Asp
        3395                3400                3405            
Ala Thr Glu Ile Asp Ser Leu Asp Gly Tyr Asp Leu Gln Asp Glu Asp
    3410                3415                3420                
Asp Gly Leu Thr Glu Ser Asp Ser Lys Leu Pro Ile Gln Ala Met Glu
3425                3430                3435                3440
Ile Lys Lys Asp Ile Trp Asn Thr Glu Gly Ile Leu Lys Pro Ala Asp
                3445                3450                3455    
Arg Ser Phe Ser Gln Ser Lys Leu Glu Val Ile Glu Glu Glu Gly Lys
            3460                3465                3470        
Val Gly Pro Asp Glu Asp Lys Pro Pro Ser Lys Ser Ser Ser Ser Glu
        3475                3480                3485            
Lys Thr Pro Asp Lys Thr Asp Gln Lys Ser Gly Ala Gln Phe Phe Thr
    3490                3495                3500                
Leu Glu Gly Arg His Pro Asp Arg Ser Val Phe Pro Asp Thr Tyr Phe
3505                3510                3515                3520
Ser Tyr Lys Val Asp Glu Glu Phe Ala Thr Pro Phe Lys Thr Val Ala
                3525                3530                3535    
Thr Lys Gly Leu Asp Phe Asp Pro Trp Ser Asn Asn Arg Gly Asp Asp
            3540                3545                3550        
Glu Val Phe Asp Ser Lys Ser Arg Glu Asp Glu Thr Lys Pro Phe Gly
        3555                3560                3565            
Leu Ala Val Glu Asp Arg Ser Pro Ala Thr Thr Pro Asp Thr Thr Pro
    3570                3575                3580                
Ala Arg Thr Pro Thr Asp Glu Ser Thr Pro Thr Ser Glu Pro Asn Pro
3585                3590                3595                3600
Phe Pro Phe His Glu Gly Lys Met Phe Glu Met Thr Arg Ser Gly Ala
                3605                3610                3615    
Ile Asp Met Ser Lys Arg Asp Phe Val Glu Glu Arg Leu Gln Phe Phe
            3620                3625                3630        
Gln Ile Gly Glu His Thr Ser Glu Gly Lys Ser Gly Asp Gln Gly Glu
        3635                3640                3645            
Gly Asp Lys Ser Met Val Thr Ala Thr Pro Gln Pro Gln Ser Gly Asp
    3650                3655                3660                
Thr Thr Val Glu Thr Asn Leu Glu Arg Asn Val Glu Thr Pro Thr Val
3665                3670                3675                3680
Glu Pro Asn Pro Ser Ile Pro Thr Ser Gly Glu Cys Gln Glu Gly Thr
                3685                3690                3695    
Ser Ser Ser Gly Ser Leu Glu Lys Ser Ala Ala Ala Thr Asn Thr Ser
            3700                3705                3710        
Lys Val Asp Pro Lys Leu Arg Thr Pro Ile Lys Met Gly Ile Ser Ala
        3715                3720                3725            
Ser Thr Met Thr Met Lys Lys Glu Gly Pro Gly Glu Ile Thr Asp Lys
    3730                3735                3740                
Ile Glu Ala Val Met Thr Ser Cys Gln Gly Leu Glu Asn Glu Thr Ile
3745                3750                3755                3760
Thr Met Ile Ser Asn Thr Ala Asn Ser Gln Met Gly Val Arg Pro His
                3765                3770                3775    
Glu Lys His Asp Phe Gln Lys Asp Asn Phe Asn Asn Asn Asn Asn Leu
            3780                3785                3790        
Asp Ser Ser Thr Ile Gln Thr Asp Asn Ile Met Ser Asn Ile Val Leu
        3795                3800                3805            
Thr Glu His Ser Ala Pro Thr Cys Thr Thr Glu Lys Asp Asn Pro Val
    3810                3815                3820                
Lys Val Ser Ser Gly Lys Lys Thr Gly Val Leu Gln Gly His Cys Val
3825                3830                3835                3840
Arg Asp Lys Gln Lys Val Leu Gly Glu Gln Gln Lys Thr Lys Glu Leu
                3845                3850                3855    
Ile Gly Ile Arg Gln Lys Ser Lys Leu Pro Ile Lys Ala Thr Ser Pro
            3860                3865                3870        
Lys Asp Thr Phe Pro Pro Asn His Met Ser Asn Thr Lys Ala Ser Lys
        3875                3880                3885            
Met Lys Gln Val Ser Gln Ser Glu Lys Thr Lys Ala Leu Thr Thr Ser
    3890                3895                3900                
Ser Cys Val Asp Val Lys Ser Arg Ile Pro Val Lys Asn Thr Pro Arg
3905                3910                3915                3920
Asp Asn Ile Ile Ala Val Arg Lys Ala Cys Ala Thr Gln Lys Gln Gly
                3925                3930                3935    
Gln Pro Glu Lys Gly Lys Ala Lys Gln Leu Pro Ser Lys Leu Pro Val
            3940                3945                3950        
Lys Val Arg Ser Thr Cys Val Thr Thr Thr Thr Thr Thr Ala Thr Thr
        3955                3960                3965            
Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ser Cys Thr Val Lys Val
    3970                3975                3980                
Arg Lys Ser Gln Leu Lys Glu Val Cys Lys His Ser Ile Glu Tyr Phe
3985                3990                3995                4000
Lys Gly Ile Ser Gly Glu Thr Leu Lys Leu Val Asp Arg Leu Ser Glu
                4005                4010                4015    
Glu Glu Lys Lys Met Gln Ser Glu Leu Ser Asp Glu Glu Glu Ser Thr
            4020                4025                4030        
Ser Arg Asn Thr Ser Leu Ser Glu Thr Ser Arg Gly Gly Gln Pro Ser
        4035                4040                4045            
Val Thr Thr Lys Ser Ala Arg Asp Lys Lys Thr Glu Ala Ala Pro Leu
    4050                4055                4060                
Lys Ser Lys Ser Glu Lys Ala Gly Ser Glu Lys Arg Ser Ser Arg Arg
4065                4070                4075                4080
Thr Gly Pro Gln Ser Pro Cys Glu Arg Thr Asp Ile Arg Met Ala Ile
                4085                4090                4095    
Val Ala Asp His Leu Gly Leu Ser Trp Thr Glu Leu Ala Arg Glu Leu
            4100                4105                4110        
Asn Phe Ser Val Asp Glu Ile Asn Gln Ile Arg Val Glu Asn Pro Asn
        4115                4120                4125            
Ser Leu Ile Ser Gln Ser Phe Met Leu Leu Lys Lys Trp Val Thr Arg
    4130                4135                4140                
Asp Gly Lys Asn Ala Thr Thr Asp Ala Leu Thr Ser Val Leu Thr Lys
4145                4150                4155                4160
Ile Asn Arg Ile Asp Ile Val Thr Leu Leu Glu Gly Pro Ile Phe Asp
                4165                4170                4175    
Tyr Gly Asn Ile Ser Gly Thr Arg Ser Phe Ala Asp Glu Asn Asn Val
            4180                4185                4190        
Phe His Asp Pro Val Asp Gly Trp Gln Asn Glu Thr Ser Ser Gly Asn
        4195                4200                4205            
Leu Glu Ser Cys Ala Gln Ala Arg Arg Val Thr Gly Gly Leu Leu Asp
    4210                4215                4220                
Arg Leu Asp Asp Ser Pro Asp Gln Cys Arg Asp Ser Ile Thr Ser Tyr
4225                4230                4235                4240
Leu Lys Gly Glu Ala Gly Lys Phe Glu Ala Asn Gly Ser His Thr Glu
                4245                4250                4255    
Ile Thr Pro Glu Ala Lys Thr Lys Ser Tyr Phe Pro Glu Ser Gln Asn
            4260                4265                4270        
Asp Val Gly Lys Gln Ser Thr Lys Glu Thr Leu Lys Pro Lys Ile His
        4275                4280                4285            
Gly Ser Gly His Val Glu Glu Pro Ala Ser Pro Leu Ala Ala Tyr Gln
    4290                4295                4300                
Lys Ser Leu Glu Glu Thr Ser Lys Leu Ile Ile Glu Glu Thr Lys Pro
4305                4310                4315                4320
Cys Val Pro Val Ser Met Lys Lys Met Ser Arg Thr Ser Pro Ala Asp
                4325                4330                4335    
Gly Lys Pro Arg Leu Ser Leu His Glu Glu Glu Gly Ser Ser Gly Ser
            4340                4345                4350        
Glu Gln Lys Gln Gly Glu Gly Phe Lys Val Lys Thr Lys Lys Glu Ile
        4355                4360                4365            
Arg His Val Glu Lys Lys Ser His Ser
    4370                4375        


<210> 7626
<211> 2348
<212> PRT
<213> Homo sapiens

<400> 7626
Met His Pro Gly Val Val Cys Ile Met Val Arg Leu Leu Pro Arg Leu
 1               5                  10                  15      
Tyr His Glu Asp His Pro Gln Leu Ser Glu Glu Ile Gln Cys Ser Leu
            20                  25                  30          
Ala Ser His Ile Gln Ser Leu Val Lys Ser Glu Lys Asn Arg Gln Val
        35                  40                  45              
Met Cys Glu Ala Gly Leu Leu Gly Thr Leu Met Ala Ser Cys His Arg
    50                  55                  60                  
Ala Leu Val Thr Ser Gly Ser Pro Leu His Ser Arg Leu Ile Arg Ile
65                  70                  75                  80  
Phe Glu Lys Leu Ala Ser Gln Ala Ile Glu Pro Asp Val Leu Arg Gln
                85                  90                  95      
Phe Leu Gly Leu Gly Ile Pro Ser Ser Leu Ser Ala Thr Thr Lys Ile
            100                 105                 110         
Leu Asp Ser Ser His Thr His Arg Gly Asn Pro Gly Cys Ser Gly Ser
        115                 120                 125             
Gln Thr Ala Gln Gly Leu Ala Glu Gly Pro Trp Pro Ala Ala Pro Asp
    130                 135                 140                 
Ala Gly Leu His Pro Gly Val Thr Gln Ala Pro Gln Pro Leu Gly Glu
145                 150                 155                 160 
Ser Gln Asp Ser Thr Thr Ala Leu Gln Thr Ala Leu Ser Leu Ile Ser
                165                 170                 175     
Met Thr Ser Pro Arg Asn Leu Gln Pro Gln Arg Ala Ala Leu Ala Pro
            180                 185                 190         
Ser Phe Val Glu Phe Asp Met Ser Val Glu Gly Tyr Gly Cys Leu Phe
        195                 200                 205             
Ile Pro Thr Leu Ser Thr Val Met Gly Thr Ser Thr Glu Tyr Ser Val
    210                 215                 220                 
Ser Gly Gly Ile Gly Thr Gly Ala Thr Arg Pro Phe Pro Pro Pro Gly
225                 230                 235                 240 
Gly Leu Thr Phe Ser Cys Trp Phe Leu Ile Ser Arg His Gly Ala Ala
                245                 250                 255     
Thr Glu Gly His Pro Leu Arg Phe Leu Thr Leu Val Arg His Leu Ala
            260                 265                 270         
Arg Thr Glu Gln Pro Phe Val Cys Phe Ser Val Ser Leu Cys Pro Asp
        275                 280                 285             
Asp Leu Ser Leu Val Val Ser Thr Glu Glu Lys Glu Phe Gln Pro Leu
    290                 295                 300                 
Asp Val Met Glu Pro Glu Asp Asp Ser Glu Pro Ser Ala Gly Cys Gln
305                 310                 315                 320 
Leu Gln Val Arg Cys Gly Gln Leu Leu Ala Cys Gly Gln Trp His His
                325                 330                 335     
Leu Ala Val Val Val Thr Lys Glu Met Lys Arg His Cys Thr Val Ser
            340                 345                 350         
Thr Cys Leu Asp Gly Gln Val Ile Gly Ser Ala Lys Met Leu Tyr Ile
        355                 360                 365             
Gln Ala Leu Pro Gly Pro Phe Leu Ser Met Asp Pro Ser Ala Phe Val
    370                 375                 380                 
Asp Val Tyr Gly Tyr Ile Ala Thr Pro Arg Val Trp Lys Gln Lys Ser
385                 390                 395                 400 
Ser Leu Ile Trp Arg Leu Gly Pro Thr Tyr Leu Phe Glu Glu Ala Ile
                405                 410                 415     
Ser Met Glu Thr Leu Glu Val Ile Asn Lys Leu Gly Pro Arg Tyr Cys
            420                 425                 430         
Gly Asn Phe Gln Ala Val His Val Gln Gly Glu Asp Leu Asp Ser Glu
        435                 440                 445             
Ala Thr Pro Phe Val Ala Glu Glu Arg Val Ser Phe Gly Leu His Ile
    450                 455                 460                 
Ala Ser Ser Ser Ile Thr Ser Val Ala Asp Ile Arg Asn Ala Tyr Asn
465                 470                 475                 480 
Glu Val Asp Ser Arg Leu Ile Ala Lys Glu Met Asn Ile Ser Ser Arg
                485                 490                 495     
Asp Asn Ala Met Pro Val Phe Leu Leu Arg Asn Cys Ala Gly His Leu
            500                 505                 510         
Ser Gly Ser Leu Arg Thr Ile Gly Ala Val Ala Val Gly Gln Leu Gly
        515                 520                 525             
Val Arg Val Phe His Ser Ser Pro Ala Ala Ser Ser Leu Asp Phe Ile
    530                 535                 540                 
Gly Gly Pro Ala Ile Leu Leu Gly Leu Ile Ser Leu Ala Thr Asp Asp
545                 550                 555                 560 
His Thr Met Tyr Ala Ala Val Lys Val Leu His Ser Val Leu Thr Ser
                565                 570                 575     
Asn Ala Met Cys Asp Phe Leu Met Gln His Ile Cys Gly Tyr Gln Ile
            580                 585                 590         
Met Ala Phe Leu Leu Arg Lys Lys Ala Ser Leu Leu Asn His Arg Ile
        595                 600                 605             
Phe Gln Leu Ile Leu Ser Val Ala Gly Thr Val Glu Leu Gly Phe Arg
    610                 615                 620                 
Ser Ser Ala Ile Thr Asn Thr Gly Val Phe Gln His Ile Leu Cys Asn
625                 630                 635                 640 
Phe Glu Leu Trp Met Asn Thr Ala Asp Asn Leu Glu Leu Ser Leu Phe
                645                 650                 655     
Ser His Leu Leu Glu Ile Leu Gln Ser Pro Arg Glu Gly Pro Arg Asn
            660                 665                 670         
Ala Glu Ala Ala His Gln Ala Gln Leu Ile Pro Lys Leu Ile Phe Leu
        675                 680                 685             
Phe Asn Glu Pro Ser Leu Ile Pro Ser Lys Ile Ser Thr Ile Ile Gly
    690                 695                 700                 
Ile Leu Ala Cys Gln Leu Arg Gly His Phe Ser Thr Gln Asp Leu Leu
705                 710                 715                 720 
Arg Ile Gly Leu Phe Val Val Tyr Thr Leu Lys Pro Ser Ser Val Asn
                725                 730                 735     
Glu Arg Gln Ile Cys Met Asp Gly Ala Leu Asp Pro Ser Leu Pro Ala
            740                 745                 750         
Gly Ser Gln Thr Ser Gly Lys Thr Ile Trp Leu Arg Asn Gln Leu Leu
        755                 760                 765             
Glu Met Leu Leu Ser Val Ile Ser Ser Pro Gln Leu His Leu Ser Ser
    770                 775                 780                 
Glu Ser Lys Glu Glu Met Phe Leu Lys Leu Gly Pro Asp Trp Phe Leu
785                 790                 795                 800 
Leu Leu Leu Gln Gly His Leu His Ala Ser Thr Thr Val Leu Ala Leu
                805                 810                 815     
Lys Leu Leu Leu Tyr Phe Leu Ala Ser Pro Ser Leu Arg Thr Arg Phe
            820                 825                 830         
Arg Asp Gly Leu Cys Ala Gly Ser Trp Val Glu Arg Ser Thr Glu Gly
        835                 840                 845             
Val Asp Ile Val Met Asp Asn Leu Lys Ser Gln Ser Pro Leu Pro Glu
    850                 855                 860                 
Gln Ser Pro Cys Leu Leu Pro Gly Phe Arg Val Leu Asn Asp Phe Leu
865                 870                 875                 880 
Ala His His Val His Ile Pro Glu Val Tyr Leu Ile Val Ser Thr Phe
                885                 890                 895     
Phe Leu Gln Thr Pro Leu Thr Glu Leu Met Asp Gly Pro Lys Asp Ser
            900                 905                 910         
Leu Asp Ala Met Leu Gln Trp Leu Leu Gln Arg His His Gln Glu Glu
        915                 920                 925             
Val Leu Gln Ala Gly Leu Cys Thr Glu Gly Ala Leu Leu Leu Leu Glu
    930                 935                 940                 
Met Leu Lys Ala Thr Met Ser Gln Pro Leu Ala Gly Ser Glu Asp Gly
945                 950                 955                 960 
Ala Trp Ala Gln Thr Phe Pro Ala Ser Val Leu Gln Phe Leu Ser Leu
                965                 970                 975     
Val His Arg Thr Tyr Pro Gln Asp Pro Ala Trp Arg Ala Pro Glu Phe
            980                 985                 990         
Leu Gln Thr Leu Ala Ile Ala Ala Phe Pro Leu Gly Ala Gln Lys Gly
        995                 1000                1005            
Val Gly Ala Glu Ser Thr Arg Asn Thr Ser Ser Pro Glu Ala Ala Ala
    1010                1015                1020                
Glu Gly Asp Ser Thr Val Glu Gly Leu Gln Ala Pro Thr Lys Ala His
1025                1030                1035                1040
Pro Ala Arg Arg Lys Leu Arg Glu Phe Thr Gln Leu Leu Leu Arg Glu
                1045                1050                1055    
Leu Leu Leu Gly Ala Ser Ser Pro Lys Gln Trp Leu Pro Leu Glu Val
            1060                1065                1070        
Leu Leu Glu Ala Ser Pro Asp His Ala Thr Ser Gln Gln Lys Arg Asp
        1075                1080                1085            
Phe Gln Ser Glu Val Leu Leu Ser Ala Met Glu Leu Phe His Met Thr
    1090                1095                1100                
Ser Gly Gly Asp Ala Ala Met Phe Arg Asp Gly Lys Glu Pro Gln Pro
1105                1110                1115                1120
Ser Ala Glu Ala Ala Ala Ala Pro Ser Leu Ala Asn Ile Ser Cys Phe
                1125                1130                1135    
Thr Gln Lys Leu Val Glu Lys Leu Tyr Ser Gly Met Phe Ser Ala Asp
            1140                1145                1150        
Pro Arg His Ile Leu Leu Phe Ile Leu Glu His Ile Met Val Val Ile
        1155                1160                1165            
Glu Thr Ala Ser Ser Gln Arg Asp Thr Val Leu Ser Thr Leu Tyr Ser
    1170                1175                1180                
Ser Leu Asn Lys Val Ile Leu Tyr Cys Leu Ser Lys Pro Gln Gln Ser
1185                1190                1195                1200
Leu Ser Glu Cys Leu Gly Leu Leu Ser Ile Leu Gly Phe Leu Gln Glu
                1205                1210                1215    
His Trp Asp Val Val Phe Ala Thr Tyr Asn Ser Asn Ile Ser Phe Leu
            1220                1225                1230        
Leu Cys Leu Met His Cys Leu Leu Leu Leu Asn Glu Arg Ser Tyr Pro
        1235                1240                1245            
Glu Gly Phe Gly Leu Glu Pro Lys Pro Arg Met Ser Thr Tyr His Gln
    1250                1255                1260                
Val Phe Leu Ser Pro Asn Glu Asp Val Lys Glu Lys Arg Glu Asp Leu
1265                1270                1275                1280
Pro Ser Leu Ser Asp Val Gln His Asn Ile Gln Lys Thr Val Gln Thr
                1285                1290                1295    
Leu Trp Gln Gln Leu Val Ala Gln Arg Gln Gln Thr Leu Glu Asp Ala
            1300                1305                1310        
Phe Lys Ile Asp Leu Ser Val Lys Pro Gly Glu Arg Glu Val Lys Ile
        1315                1320                1325            
Glu Glu Val Thr Pro Leu Trp Glu Glu Thr Met Leu Lys Ala Trp Gln
    1330                1335                1340                
His Tyr Leu Ala Ser Glu Lys Lys Ser Leu Ala Ser Arg Ser Asn Val
1345                1350                1355                1360
Ala His His Ser Lys Val Thr Leu Trp Ser Gly Ser Leu Ser Ser Ala
                1365                1370                1375    
Met Lys Leu Met Pro Gly Arg Gln Ala Lys Asp Pro Glu Cys Lys Thr
            1380                1385                1390        
Glu Asp Phe Val Ser Cys Ile Glu Asn Tyr Arg Arg Arg Gly Gln Glu
        1395                1400                1405            
Leu Tyr Ala Ser Leu Tyr Lys Asp His Val Gln Arg Arg Lys Cys Gly
    1410                1415                1420                
Asn Ile Lys Ala Ala Asn Ala Trp Ala Arg Ile Gln Glu Gln Leu Phe
1425                1430                1435                1440
Gly Glu Leu Gly Leu Trp Ser Gln Gly Glu Glu Thr Lys Pro Cys Ser
                1445                1450                1455    
Pro Trp Glu Leu Asp Trp Arg Glu Gly Pro Ala Arg Met Arg Lys Arg
            1460                1465                1470        
Ile Lys Arg Leu Ser Pro Leu Glu Ala Leu Ser Ser Gly Arg His Lys
        1475                1480                1485            
Glu Ser Gln Asp Lys Asn Asp His Ile Ser Gln Thr Asn Ala Glu Asn
    1490                1495                1500                
Gln Asp Glu Leu Thr Leu Arg Glu Ala Glu Gly Glu Pro Asp Glu Val
1505                1510                1515                1520
Gly Val Asp Cys Thr Gln Leu Thr Phe Phe Pro Ala Leu His Glu Ser
                1525                1530                1535    
Leu His Ser Glu Asp Phe Leu Glu Leu Cys Arg Glu Arg Gln Val Ile
            1540                1545                1550        
Leu Gln Glu Leu Leu Asp Lys Glu Lys Val Thr Gln Lys Phe Ser Leu
        1555                1560                1565            
Val Ile Val Gln Gly His Leu Val Ser Glu Gly Val Leu Leu Phe Gly
    1570                1575                1580                
His Gln His Phe Tyr Ile Cys Glu Asn Phe Thr Leu Ser Pro Thr Gly
1585                1590                1595                1600
Asp Val Tyr Cys Thr Arg His Cys Leu Ser Asn Ile Ser Asp Pro Phe
                1605                1610                1615    
Ile Phe Asn Leu Cys Ser Lys Asp Arg Ser Thr Asp His Tyr Ser Cys
            1620                1625                1630        
Gln Cys His Ser Tyr Ala Asp Met Arg Glu Leu Arg Gln Ala Arg Phe
        1635                1640                1645            
Leu Leu Gln Asp Ile Ala Leu Glu Ile Phe Phe His Asn Gly Tyr Ser
    1650                1655                1660                
Lys Phe Leu Val Phe Tyr Asn Asn Asp Arg Ser Lys Ala Phe Lys Ser
1665                1670                1675                1680
Phe Cys Ser Phe Gln Pro Ser Leu Lys Gly Lys Ala Thr Ser Glu Asp
                1685                1690                1695    
Thr Leu Ser Leu Arg Arg Tyr Pro Gly Ser Asp Arg Ile Met Leu Gln
            1700                1705                1710        
Lys Trp Gln Lys Arg Asp Ile Ser Asn Phe Glu Tyr Leu Met Tyr Leu
        1715                1720                1725            
Asn Thr Ala Ala Gly Arg Thr Cys Asn Asp Tyr Met Gln Tyr Pro Val
    1730                1735                1740                
Phe Pro Trp Val Leu Ala Asp Tyr Thr Ser Glu Thr Leu Asn Leu Ala
1745                1750                1755                1760
Asn Pro Lys Ile Phe Arg Asp Leu Ser Lys Pro Met Gly Ala Gln Thr
                1765                1770                1775    
Lys Glu Arg Lys Leu Lys Phe Ile Gln Arg Phe Lys Glu Val Glu Lys
            1780                1785                1790        
Thr Glu Gly Asp Met Thr Val Gln Cys His Tyr Tyr Thr His Tyr Ser
        1795                1800                1805            
Ser Ala Ile Ile Val Ala Ser Tyr Leu Val Arg Met Pro Pro Phe Thr
    1810                1815                1820                
Gln Ala Phe Cys Ala Leu Gln Gly Gly Ser Phe Asp Val Ala Asp Arg
1825                1830                1835                1840
Met Phe His Ser Val Lys Ser Thr Trp Glu Ser Ala Ser Arg Glu Asn
                1845                1850                1855    
Met Ser Asp Val Arg Glu Leu Thr Pro Glu Phe Phe Tyr Leu Pro Glu
            1860                1865                1870        
Phe Leu Thr Asn Cys Asn Gly Val Glu Phe Gly Cys Met Gln Asp Gly
        1875                1880                1885            
Thr Val Leu Gly Asp Val Gln Leu Pro Pro Trp Ala Asp Gly Asp Pro
    1890                1895                1900                
Arg Lys Phe Ile Ser Leu His Arg Lys Ala Leu Glu Ser Asp Phe Val
1905                1910                1915                1920
Ser Ala Asn Leu His His Trp Ile Asp Leu Ile Phe Gly Tyr Lys Gln
                1925                1930                1935    
Gln Gly Pro Ala Ala Val Asp Ala Val Asn Ile Phe His Pro Tyr Phe
            1940                1945                1950        
Tyr Gly Asp Arg Met Asp Leu Ser Ser Ile Thr Asp Pro Leu Ile Lys
        1955                1960                1965            
Ser Thr Ile Leu Gly Phe Val Ser Asn Phe Gly Gln Val Pro Lys Gln
    1970                1975                1980                
Leu Phe Thr Lys Pro His Pro Ala Arg Thr Ala Ala Gly Lys Pro Leu
1985                1990                1995                2000
Pro Gly Lys Asp Val Ser Thr Pro Val Ser Leu Pro Gly His Pro Gln
                2005                2010                2015    
Pro Phe Phe Tyr Ser Leu Gln Ser Leu Arg Pro Ser Gln Val Thr Val
            2020                2025                2030        
Lys Asp Met Tyr Leu Phe Ser Leu Gly Ser Glu Ser Pro Lys Gly Ala
        2035                2040                2045            
Ile Gly His Ile Val Ser Thr Glu Lys Thr Ile Leu Ala Val Glu Arg
    2050                2055                2060                
Asn Lys Val Leu Leu Pro Pro Leu Trp Asn Arg Thr Phe Ser Trp Gly
2065                2070                2075                2080
Phe Asp Asp Phe Ser Cys Cys Leu Gly Ser Tyr Gly Ser Asp Lys Val
                2085                2090                2095    
Leu Met Thr Phe Glu Asn Leu Ala Ala Trp Gly Arg Cys Leu Cys Ala
            2100                2105                2110        
Val Cys Pro Ser Pro Thr Thr Ile Val Thr Ser Gly Thr Ser Thr Val
        2115                2120                2125            
Val Cys Val Trp Glu Leu Ser Met Thr Lys Gly Arg Pro Arg Gly Leu
    2130                2135                2140                
Arg Leu Arg Gln Ala Leu Tyr Gly His Thr Gln Ala Val Thr Cys Leu
2145                2150                2155                2160
Ala Ala Ser Val Thr Phe Ser Leu Leu Val Ser Gly Ser Gln Asp Cys
                2165                2170                2175    
Thr Cys Ile Leu Trp Asp Leu Asp His Leu Thr His Val Thr Arg Leu
            2180                2185                2190        
Pro Ala His Arg Glu Gly Ile Ser Ala Ile Thr Ile Ser Asp Val Ser
        2195                2200                2205            
Gly Thr Ile Val Ser Cys Ala Gly Ala His Leu Ser Leu Trp Asn Val
    2210                2215                2220                
Asn Gly Gln Pro Leu Ala Ser Ile Thr Thr Ala Trp Gly Pro Glu Gly
2225                2230                2235                2240
Ala Ile Thr Cys Cys Cys Leu Met Glu Gly Pro Ala Trp Asp Thr Ser
                2245                2250                2255    
Gln Ile Ile Ile Thr Gly Ser Gln Asp Gly Met Val Arg Val Trp Lys
            2260                2265                2270        
Thr Glu Asp Val Lys Met Ser Val Pro Gly Leu Gln Met Gly Arg Lys
        2275                2280                2285            
Arg Glu Ala Ala Glu Ala Leu Ala Gln Gln Cys Gln Ala Glu Gly Gly
    2290                2295                2300                
Arg Gly Asp Trp Gly Leu Ser Ser Ala Tyr Arg Arg Asn Pro Gln Gly
2305                2310                2315                2320
Leu Leu Pro His Ser Ser Gln Gly Arg Ala Ser Gly Asn His Ser Ser
                2325                2330                2335    
Ala Ala Gln Pro Ser Pro Trp Pro Met Gly Leu Leu
            2340                2345            


<210> 7627
<211> 1270
<212> PRT
<213> Homo sapiens

<400> 7627
Arg Asp Phe Gln Ser Glu Val Leu Leu Ser Ala Met Glu Leu Phe His
 1               5                  10                  15      
Met Thr Ser Gly Gly Asp Ala Ala Met Phe Arg Asp Gly Lys Glu Pro
            20                  25                  30          
Gln Pro Ser Ala Glu Ala Ala Ala Ala Pro Ser Leu Ala Asn Ile Ser
        35                  40                  45              
Cys Phe Thr Gln Lys Leu Val Glu Lys Leu Tyr Ser Gly Met Phe Ser
    50                  55                  60                  
Ala Asp Pro Arg His Ile Leu Leu Phe Ile Leu Glu His Ile Met Val
65                  70                  75                  80  
Val Ile Glu Thr Ala Ser Ser Gln Arg Asp Thr Val Leu Ser Thr Leu
                85                  90                  95      
Tyr Ser Ser Leu Asn Lys Val Ile Leu Tyr Cys Leu Ser Lys Pro Gln
            100                 105                 110         
Gln Ser Leu Ser Glu Cys Leu Gly Leu Leu Ser Ile Leu Gly Phe Leu
        115                 120                 125             
Gln Glu His Trp Asp Val Val Phe Ala Thr Tyr Asn Ser Asn Ile Ser
    130                 135                 140                 
Phe Leu Leu Cys Leu Met His Cys Leu Leu Leu Leu Asn Glu Arg Ser
145                 150                 155                 160 
Tyr Pro Glu Gly Phe Gly Leu Glu Pro Lys Pro Arg Met Ser Thr Tyr
                165                 170                 175     
His Gln Val Phe Leu Ser Pro Asn Glu Asp Val Lys Glu Lys Arg Glu
            180                 185                 190         
Asp Leu Pro Ser Leu Ser Asp Val Gln His Asn Ile Gln Lys Thr Val
        195                 200                 205             
Gln Thr Leu Trp Gln Gln Leu Val Ala Gln Arg Gln Gln Thr Leu Glu
    210                 215                 220                 
Asp Ala Phe Lys Ile Asp Leu Ser Val Lys Pro Gly Glu Arg Glu Val
225                 230                 235                 240 
Lys Ile Glu Glu Val Thr Pro Leu Trp Glu Glu Thr Met Leu Lys Ala
                245                 250                 255     
Trp Gln His Tyr Leu Ala Ser Glu Lys Lys Ser Leu Ala Ser Arg Ser
            260                 265                 270         
Asn Val Ala His His Ser Lys Val Thr Leu Trp Ser Gly Ser Leu Ser
        275                 280                 285             
Ser Ala Met Lys Leu Met Pro Gly Arg Gln Ala Lys Asp Pro Glu Cys
    290                 295                 300                 
Lys Thr Glu Asp Phe Val Ser Cys Ile Glu Asn Tyr Arg Arg Arg Gly
305                 310                 315                 320 
Gln Glu Leu Tyr Ala Ser Leu Tyr Lys Asp His Val Gln Arg Arg Lys
                325                 330                 335     
Cys Gly Asn Ile Lys Ala Ala Asn Ala Trp Ala Arg Ile Gln Glu Gln
            340                 345                 350         
Leu Phe Gly Glu Leu Gly Leu Trp Ser Gln Gly Glu Glu Thr Lys Pro
        355                 360                 365             
Cys Ser Pro Trp Glu Leu Asp Trp Arg Glu Gly Pro Ala Arg Met Arg
    370                 375                 380                 
Lys Arg Ile Lys Arg Leu Ser Pro Leu Glu Ala Leu Ser Ser Gly Arg
385                 390                 395                 400 
His Lys Glu Ser Gln Asp Lys Asn Asp His Ile Ser Gln Thr Asn Ala
                405                 410                 415     
Glu Asn Gln Asp Glu Leu Thr Leu Arg Glu Ala Glu Gly Glu Pro Asp
            420                 425                 430         
Glu Val Gly Val Asp Cys Thr Gln Leu Thr Phe Phe Pro Ala Leu His
        435                 440                 445             
Glu Ser Leu His Ser Glu Asp Phe Leu Glu Leu Cys Arg Glu Arg Gln
    450                 455                 460                 
Val Ile Leu Gln Glu Leu Leu Asp Lys Glu Lys Val Thr Gln Lys Phe
465                 470                 475                 480 
Ser Leu Val Ile Val Gln Gly His Leu Val Ser Glu Gly Val Leu Leu
                485                 490                 495     
Phe Gly His Gln His Phe Tyr Ile Cys Glu Asn Phe Thr Leu Ser Pro
            500                 505                 510         
Thr Gly Asp Val Tyr Cys Thr Arg His Cys Leu Ser Asn Ile Ser Asp
        515                 520                 525             
Pro Phe Ile Phe Asn Leu Cys Ser Lys Asp Arg Ser Thr Asp His Tyr
    530                 535                 540                 
Ser Cys Gln Cys His Ser Tyr Ala Asp Met Arg Glu Leu Arg Gln Ala
545                 550                 555                 560 
Arg Phe Leu Leu Gln Asp Ile Ala Leu Glu Ile Phe Phe His Asn Gly
                565                 570                 575     
Tyr Ser Lys Phe Leu Val Phe Tyr Asn Asn Asp Arg Ser Lys Ala Phe
            580                 585                 590         
Lys Ser Phe Cys Ser Phe Gln Pro Ser Leu Lys Gly Lys Ala Thr Ser
        595                 600                 605             
Glu Asp Thr Leu Asn Leu Arg Arg Tyr Pro Gly Ser Asp Arg Ile Met
    610                 615                 620                 
Leu Gln Lys Trp Gln Lys Arg Asp Ile Ser Asn Phe Glu Tyr Leu Met
625                 630                 635                 640 
Tyr Leu Asn Thr Ala Ala Gly Arg Thr Cys Asn Asp Tyr Met Gln Tyr
                645                 650                 655     
Pro Val Phe Pro Trp Val Leu Ala Asp Tyr Thr Ser Glu Thr Leu Asn
            660                 665                 670         
Leu Ala Asn Pro Lys Ile Phe Arg Asp Leu Ser Lys Pro Met Gly Ala
        675                 680                 685             
Gln Thr Lys Glu Arg Lys Leu Lys Phe Ile Gln Arg Phe Lys Glu Val
    690                 695                 700                 
Glu Lys Thr Glu Gly Asp Met Thr Val Gln Cys His Tyr Tyr Thr His
705                 710                 715                 720 
Tyr Ser Ser Ala Ile Ile Val Ala Ser Tyr Leu Val Arg Met Pro Pro
                725                 730                 735     
Phe Thr Gln Ala Phe Cys Ala Leu Gln Gly Gly Ser Phe Asp Val Ala
            740                 745                 750         
Asp Arg Met Phe His Ser Val Lys Ser Thr Trp Glu Ser Ala Ser Arg
        755                 760                 765             
Glu Asn Met Ser Asp Val Arg Glu Leu Thr Pro Glu Phe Phe Tyr Leu
    770                 775                 780                 
Pro Glu Phe Leu Thr Asn Cys Asn Gly Val Glu Phe Gly Cys Met Gln
785                 790                 795                 800 
Asp Gly Thr Val Leu Gly Asp Val Gln Leu Pro Pro Trp Ala Asp Gly
                805                 810                 815     
Asp Pro Arg Lys Phe Ile Ser Leu His Arg Lys Ala Leu Glu Ser Asp
            820                 825                 830         
Phe Val Ser Ala Asn Leu His His Trp Ile Asp Leu Ile Phe Gly Tyr
        835                 840                 845             
Lys Gln Gln Gly Pro Ala Ala Val Asp Ala Val Asn Ile Phe His Pro
    850                 855                 860                 
Tyr Phe Tyr Gly Asp Arg Met Asp Leu Ser Ser Ile Thr Asp Pro Leu
865                 870                 875                 880 
Ile Lys Ser Thr Ile Leu Gly Phe Val Ser Asn Phe Gly Gln Val Pro
                885                 890                 895     
Lys Gln Leu Phe Thr Lys Pro His Pro Ala Arg Thr Ala Ala Gly Lys
            900                 905                 910         
Pro Leu Pro Gly Lys Asp Val Ser Thr Pro Val Ser Leu Pro Gly His
        915                 920                 925             
Pro Gln Pro Phe Phe Tyr Ser Leu Gln Ser Leu Arg Pro Ser Gln Val
    930                 935                 940                 
Thr Val Lys Asp Met Tyr Leu Phe Ser Leu Gly Ser Glu Ser Pro Lys
945                 950                 955                 960 
Gly Ala Ile Gly His Ile Val Ser Thr Glu Lys Thr Ile Leu Ala Val
                965                 970                 975     
Glu Arg Asn Lys Val Leu Leu Pro Pro Leu Trp Asn Arg Thr Phe Ser
            980                 985                 990         
Trp Gly Phe Asp Asp Phe Ser Cys Cys Leu Gly Ser Tyr Gly Ser Asp
        995                 1000                1005            
Lys Val Leu Met Thr Phe Glu Asn Leu Ala Ala Trp Gly Arg Cys Leu
    1010                1015                1020                
Cys Ala Val Cys Pro Ser Pro Thr Thr Ile Val Thr Ser Gly Thr Ser
1025                1030                1035                1040
Thr Val Val Cys Val Trp Glu Leu Ser Met Thr Lys Gly Arg Pro Arg
                1045                1050                1055    
Gly Leu Arg Leu Arg Gln Ala Leu Tyr Gly His Thr Gln Ala Val Thr
            1060                1065                1070        
Cys Leu Ala Ala Ser Val Thr Phe Ser Leu Leu Val Ser Gly Ser Gln
        1075                1080                1085            
Asp Cys Thr Cys Ile Leu Trp Asp Leu Asp His Leu Thr His Val Thr
    1090                1095                1100                
Arg Leu Pro Ala His Arg Glu Gly Ile Ser Ala Ile Thr Ile Ser Asp
1105                1110                1115                1120
Val Ser Gly Thr Ile Val Ser Cys Ala Gly Ala His Leu Ser Leu Trp
                1125                1130                1135    
Asn Val Asn Gly Gln Pro Leu Ala Ser Ile Thr Thr Ala Trp Gly Pro
            1140                1145                1150        
Glu Gly Ala Ile Thr Cys Cys Cys Leu Met Glu Gly Pro Ala Trp Asp
        1155                1160                1165            
Thr Ser Gln Ile Ile Ile Thr Gly Ser Gln Asp Gly Met Val Arg Val
    1170                1175                1180                
Trp Lys Thr Glu Asp Val Lys Met Ser Val Pro Gly Arg Pro Ala Gly
1185                1190                1195                1200
Glu Glu Pro Leu Ala Gln Pro Pro Ser Pro Arg Gly His Lys Trp Glu
                1205                1210                1215    
Lys Asn Leu Ala Leu Ser Arg Glu Leu Asp Val Ser Ile Ala Leu Thr
            1220                1225                1230        
Gly Lys Pro Ser Lys Thr Ser Pro Ala Val Thr Ala Leu Ala Val Ser
        1235                1240                1245            
Arg Asn His Thr Lys Leu Leu Val Gly Asp Glu Arg Gly Arg Ile Phe
    1250                1255                1260                
Cys Trp Ser Ala Asp Gly
1265                1270


<210> 7628
<211> 951
<212> PRT
<213> Homo sapiens

<400> 7628
Met Ser Arg Gly Gly Ser Tyr Pro His Leu Leu Trp Asp Val Arg Lys
 1               5                  10                  15      
Arg Ser Leu Gly Leu Glu Asp Pro Ser Arg Leu Arg Ser Arg Tyr Leu
            20                  25                  30          
Gly Arg Arg Glu Phe Ile Gln Arg Leu Lys Leu Glu Ala Thr Leu Asn
        35                  40                  45              
Val His Asp Gly Cys Val Asn Thr Ile Cys Trp Asn Asp Thr Gly Glu
    50                  55                  60                  
Tyr Ile Leu Ser Gly Ser Asp Asp Thr Lys Leu Val Ile Ser Asn Pro
65                  70                  75                  80  
Tyr Ser Arg Lys Val Leu Thr Thr Ile Arg Ser Gly His Arg Ala Asn
                85                  90                  95      
Ile Phe Ser Ala Lys Phe Leu Pro Cys Thr Asn Asp Lys Gln Ile Val
            100                 105                 110         
Ser Cys Ser Gly Asp Gly Val Ile Phe Tyr Thr Asn Val Glu Gln Asp
        115                 120                 125             
Ala Glu Thr Asn Arg Gln Cys Gln Phe Thr Cys His Tyr Gly Thr Thr
    130                 135                 140                 
Tyr Glu Ile Met Thr Val Pro Asn Asp Pro Tyr Thr Phe Leu Ser Cys
145                 150                 155                 160 
Gly Glu Asp Gly Thr Val Arg Trp Phe Asp Thr Arg Ile Lys Thr Ser
                165                 170                 175     
Cys Thr Lys Glu Asp Cys Lys Asp Asp Ile Leu Ile Asn Cys Arg Arg
            180                 185                 190         
Ala Ala Thr Ser Val Ala Ile Cys Pro Pro Ile Pro Tyr Tyr Leu Ala
        195                 200                 205             
Val Gly Cys Ser Asp Ser Ser Val Arg Ile Tyr Asp Arg Arg Met Leu
    210                 215                 220                 
Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr Gly Met
225                 230                 235                 240 
Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser Cys Arg Val
                245                 250                 255     
Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val Ser Tyr
            260                 265                 270         
Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr Ala Arg
        275                 280                 285             
Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu Arg Gln
    290                 295                 300                 
Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp Thr Gly
305                 310                 315                 320 
Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu Gln Ser
                325                 330                 335     
Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu Ser Arg Trp
            340                 345                 350         
Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly Arg Gly Arg
        355                 360                 365             
Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr Leu Pro
    370                 375                 380                 
Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr Ala Met Glu
385                 390                 395                 400 
Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr
                405                 410                 415     
Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu Ser Pro His
            420                 425                 430         
Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln Ser Val
        435                 440                 445             
Glu Ala Ser Gly His His Thr His His Gln Ser Glu Phe Leu Arg Gly
    450                 455                 460                 
Pro Glu Ile Ala Leu Leu Arg Lys Arg Leu Gln Gln Leu Arg Leu Lys
465                 470                 475                 480 
Lys Ala Glu Gln Gln Arg Gln Gln Glu Leu Ala Ala His Thr Gln Gln
                485                 490                 495     
Gln Pro Ser Thr Ser Asp Gln Ser Ser His Glu Gly Ser Ser Gln Asp
            500                 505                 510         
Pro His Ala Ser Asp Ser Pro Ser Ser Val Val Asn Lys Gln Leu Gly
        515                 520                 525             
Ser Met Ser Leu Asp Glu Gln Gln Asp Asn Asn Asn Glu Lys Leu Ser
    530                 535                 540                 
Pro Lys Pro Gly Thr Gly Glu Pro Val Leu Ser Leu His Tyr Ser Thr
545                 550                 555                 560 
Glu Gly Thr Thr Thr Ser Thr Ile Lys Leu Asn Phe Thr Asp Glu Trp
                565                 570                 575     
Ser Ser Ile Ala Ser Ser Ser Arg Gly Ile Gly Ser His Cys Lys Ser
            580                 585                 590         
Glu Gly Gln Glu Glu Ser Phe Val Pro Gln Ser Ser Val Gln Pro Pro
        595                 600                 605             
Glu Gly Asp Ser Glu Thr Lys Ala Pro Glu Glu Ser Ser Glu Asp Val
    610                 615                 620                 
Thr Lys Tyr Gln Glu Gly Val Ser Ala Glu Asn Pro Val Glu Asn His
625                 630                 635                 640 
Ile Asn Ile Thr Gln Ser Asp Lys Phe Thr Ala Lys Pro Leu Asp Ser
                645                 650                 655     
Asn Ser Gly Glu Arg Asn Asp Leu Asn Leu Asp Arg Ser Cys Gly Val
            660                 665                 670         
Pro Glu Glu Ser Ala Ser Ser Glu Lys Ala Lys Glu Pro Glu Thr Ser
        675                 680                 685             
Asp Gln Thr Ser Thr Glu Ser Ala Thr Asn Glu Asn Asn Thr Asn Pro
    690                 695                 700                 
Glu Pro Gln Phe Gln Thr Glu Ala Thr Gly Pro Ser Ala His Glu Glu
705                 710                 715                 720 
Thr Ser Thr Arg Asp Ser Ala Leu Gln Asp Thr Asp Asp Ser Asp Asp
                725                 730                 735     
Asp Pro Val Leu Ile Pro Gly Ala Arg Tyr Arg Ala Gly Pro Gly Asp
            740                 745                 750         
Arg Phe Asn Ile Arg Gly Thr Thr Ile Gly Asp Arg Ile Met Arg Arg
        755                 760                 765             
Ser Ala Val Ala Arg Ile Gln Glu Phe Phe Arg Arg Arg Lys Glu Arg
    770                 775                 780                 
Lys Glu Met Glu Glu Leu Asp Thr Leu Asn Ile Arg Arg Pro Leu Val
785                 790                 795                 800 
Lys Met Val Tyr Lys Gly His Arg Asn Ser Arg Thr Met Ile Lys Glu
                805                 810                 815     
Ala Asn Phe Trp Gly Ala Asn Phe Val Met Ser Gly Ser Asp Cys Gly
            820                 825                 830         
His Ile Phe Ile Trp Asp Arg His Thr Ala Glu His Leu Met Leu Leu
        835                 840                 845             
Glu Ala Asp Asn His Val Val Asn Cys Leu Gln Pro His Pro Phe Asp
    850                 855                 860                 
Pro Ile Leu Ala Ser Ser Gly Ile Asp Tyr Asp Ile Lys Ile Trp Ser
865                 870                 875                 880 
Pro Leu Glu Glu Ser Arg Ile Phe Asn Arg Lys Leu Ala Asp Glu Val
                885                 890                 895     
Ile Thr Arg Asn Glu Leu Met Leu Glu Glu Thr Arg Asn Thr Ile Thr
            900                 905                 910         
Val Pro Ala Ser Phe Met Leu Arg Met Leu Ala Ser Leu Asn His Ile
        915                 920                 925             
Arg Ala Asp Arg Leu Glu Gly Asp Arg Ser Glu Gly Ser Gly Gln Glu
    930                 935                 940                 
Asn Glu Asn Glu Asp Glu Glu
945                 950     


<210> 7629
<211> 418
<212> PRT
<213> Homo sapiens

<400> 7629
Met Asp Pro Glu Ala Ser Asp Leu Ser Arg Gly Ile Leu Ala Leu Arg
 1               5                  10                  15      
Asp Val Ala Ala Glu Ala Gly Val Ser Lys Tyr Thr Gly Gly Arg Gly
            20                  25                  30          
Val Ser Val Gly Pro Ile Leu Ser Ser Ser Ala Ser Asp Ile Phe Cys
        35                  40                  45              
Asp Asn Glu Asn Gly Pro Asn Phe Leu Phe His Asn Arg Gly Asp Gly
    50                  55                  60                  
Thr Phe Val Asp Ala Ala Ala Ser Ala Gly Val Asp Asp Pro His Gln
65                  70                  75                  80  
His Gly Arg Gly Val Ala Leu Ala Asp Phe Asn Arg Asp Gly Lys Val
                85                  90                  95      
Asp Ile Val Tyr Gly Asn Trp Asn Gly Pro His Arg Leu Tyr Leu Gln
            100                 105                 110         
Met Ser Thr His Gly Lys Val Arg Phe Arg Asp Ile Ala Ser Pro Lys
        115                 120                 125             
Phe Ser Met Pro Ser Pro Val Arg Thr Val Ile Thr Ala Asp Phe Asp
    130                 135                 140                 
Asn Asp Gln Glu Leu Glu Ile Phe Phe Asn Asn Ile Ala Tyr Arg Ser
145                 150                 155                 160 
Ser Ser Ala Asn Arg Leu Phe Arg Val Ile Arg Arg Glu His Gly Asp
                165                 170                 175     
Pro Leu Ile Glu Glu Leu Asn Pro Gly Asp Ala Leu Glu Pro Glu Gly
            180                 185                 190         
Arg Gly Thr Gly Gly Val Val Thr Asp Phe Asp Gly Asp Gly Met Leu
        195                 200                 205             
Asp Leu Ile Leu Ser His Gly Glu Ser Met Ala Gln Pro Leu Ser Val
    210                 215                 220                 
Phe Arg Gly Asn Gln Gly Phe Asn Asn Asn Trp Leu Arg Val Val Pro
225                 230                 235                 240 
Arg Thr Arg Val Gly Ala Phe Ala Arg Gly Ala Lys Val Val Leu Tyr
                245                 250                 255     
Thr Lys Lys Ser Gly Ala His Leu Arg Ile Ile Asp Gly Gly Ser Gly
            260                 265                 270         
Tyr Leu Cys Glu Met Glu Pro Val Ala His Phe Gly Leu Gly Lys Asp
        275                 280                 285             
Glu Ala Ser Ser Val Glu Val Thr Trp Pro Asp Gly Lys Met Val Ser
    290                 295                 300                 
Arg Asn Val Ala Ser Gly Glu Met Asn Ser Val Leu Glu Ile Leu Tyr
305                 310                 315                 320 
Pro Arg Asp Glu Asp Thr Leu Gln Asp Pro Ala Pro Leu Glu Thr Pro
                325                 330                 335     
Met Asn Ala Ser Ser Ser His Ser Cys Ala Leu Glu Thr Ser Pro Tyr
            340                 345                 350         
Val Ser Thr Pro Met Glu Ala Thr Gly Ala Gly Pro Thr Arg Ser Ala
        355                 360                 365             
Val Gly Ala Thr Ser Pro Thr Arg Met Ala Gln Pro Ala Trp Gly Leu
    370                 375                 380                 
Ser Ala Ser His Arg Ala Pro Ala Pro Pro Pro Pro Pro Leu Leu Leu
385                 390                 395                 400 
Pro Leu Pro Leu Leu Leu Pro Leu Leu Glu Leu Pro Leu Leu His Arg
                405                 410                 415     
Ser Ser
        


<210> 7630
<211> 890
<212> PRT
<213> Homo sapiens

<400> 7630
Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Phe Val Thr Val Lys
 1               5                  10                  15      
Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr Leu Ser Gly Cys Ile Asp
            20                  25                  30          
Ile Ile Val Ile Arg Gln Pro Asn Gly Asn Leu Gln Cys Ser Pro Phe
        35                  40                  45              
His Val Arg Phe Gly Lys Met Gly Val Leu Arg Ser Arg Glu Lys Val
    50                  55                  60                  
Val Asp Ile Glu Ile Asn Gly Glu Ser Val Asp Leu His Met Lys Leu
65                  70                  75                  80  
Gly Asp Asn Gly Glu Ala Phe Phe Val Gln Glu Thr Asp Asn Asp Gln
                85                  90                  95      
Glu Val Ile Pro Met His Leu Ala Thr Ser Pro Ile Leu Ser Glu Gly
            100                 105                 110         
Ala Ser Arg Met Glu Cys Gln Leu Lys Arg Gly Ser Val Asp Arg Met
        115                 120                 125             
Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln Val Ile Ala Pro Ser Glu
    130                 135                 140                 
Thr Pro Ser Ser Ser Ser Val Val Lys Lys Arg Arg Lys Arg Arg Arg
145                 150                 155                 160 
Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp Asp Asn Met Asn Thr Ser
                165                 170                 175     
Glu Asp Glu Asp Met Phe Pro Ile Glu Met Ser Ser Asp Glu Ala Met
            180                 185                 190         
Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro Asn Asp Ile Pro Pro Phe
        195                 200                 205             
Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser Leu Ala Val Ile Tyr Pro
    210                 215                 220                 
Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg Glu Trp Ser Pro Thr Pro
225                 230                 235                 240 
Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro Lys Ser Asp Ser Glu Leu
                245                 250                 255     
Val Ser Lys Ser Thr Glu Arg Thr Gly Gln Lys Asn Pro Glu Met Leu
            260                 265                 270         
Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala Lys Ser Ser Ser Pro His
        275                 280                 285             
Lys Met Lys Glu Ser Ser Pro Leu Ser Ser Arg Lys Ile Cys Asp Lys
    290                 295                 300                 
Ser His Phe Gln Ala Ile His Ser Glu Ser Ser Asp Thr Phe Ser Asp
305                 310                 315                 320 
Gln Ser Pro Thr Leu Val Gly Gly Ala Leu Leu Asp Gln Asn Lys Pro
                325                 330                 335     
Gln Thr Glu Met Gln Phe Val Asn Glu Glu Asp Leu Glu Thr Leu Gly
            340                 345                 350         
Ala Ala Ala Pro Leu Leu Pro Met Ile Glu Glu Leu Lys Pro Pro Ser
        355                 360                 365             
Ala Ser Val Val Gln Thr Ala Asn Lys Thr Asp Ser Pro Ser Arg Lys
    370                 375                 380                 
Arg Asp Lys Arg Ser Arg His Leu Gly Ala Asp Gly Val Tyr Leu Asp
385                 390                 395                 400 
Asp Leu Thr Asp Met Asp Pro Glu Val Ala Ala Leu Tyr Phe Pro Lys
                405                 410                 415     
Asn Gly Asp Pro Ser Gly Leu Ala Lys His Ala Ser Asp Asn Gly Ala
            420                 425                 430         
Arg Ser Ala Asn Gln Ser Pro Gln Ser Val Gly Ser Ser Gly Val Asp
        435                 440                 445             
Ser Gly Val Glu Ser Thr Ser Asp Gly Leu Arg Asp Leu Pro Ser Ile
    450                 455                 460                 
Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp His Arg Glu Ile Thr Lys
465                 470                 475                 480 
Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr Gln Gln Phe Val Asp Asn
                485                 490                 495     
Pro Ala Ile Ile Asp Asp Pro Asn Leu Val Val Lys Ile Gly Ser Lys
            500                 505                 510         
Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu Leu Leu Ala Met Gln Ala
        515                 520                 525             
Phe Gln Lys Pro Leu Pro Lys Ala Thr Val Glu Ser Ile Met Arg Asp
    530                 535                 540                 
Lys Met Pro Lys Lys Gly Gly Arg Trp Trp Phe Ser Trp Arg Gly Arg
545                 550                 555                 560 
Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro Glu Gln Cys Leu Ala Gly
                565                 570                 575     
Lys Ala His Ser Thr Gly Glu Gln Pro Pro Gln Leu Ser Leu Ala Thr
            580                 585                 590         
Arg Val Lys His Glu Ser Ser Ser Ser Asp Glu Glu Arg Ala Ala Ala
        595                 600                 605             
Lys Pro Ser Asn Ala Gly His Leu Pro Leu Leu Pro Asn Val Ser Tyr
    610                 615                 620                 
Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln Leu Lys Ser Leu Lys Leu
625                 630                 635                 640 
Lys Asn Gly Pro Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln
                645                 650                 655     
Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr Leu Trp Asn Trp Asp Asp
            660                 665                 670         
Lys Val Ile Ile Ser Asp Ile Asp Gly Thr Ile Thr Arg Ser Asp Thr
        675                 680                 685             
Leu Gly His Ile Leu Pro Thr Leu Gly Lys Asp Trp Thr His Gln Gly
    690                 695                 700                 
Ile Ala Lys Leu Tyr His Lys Val Ser Gln Asn Gly Tyr Lys Phe Leu
705                 710                 715                 720 
Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr
                725                 730                 735     
Leu His Trp Val Asn Glu Arg Gly Thr Val Leu Pro Gln Gly Pro Leu
            740                 745                 750         
Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile
        755                 760                 765             
Glu Lys Lys Pro Glu Lys Phe Lys Val Gln Cys Leu Thr Asp Ile Lys
    770                 775                 780                 
Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe Tyr Ala Ala Phe Gly Asn
785                 790                 795                 800 
Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln Val Gly Val Ser Leu Asn
                805                 810                 815     
Arg Ile Phe Thr Val Asn Pro Lys Gly Glu Leu Val Gln Glu His Ala
            820                 825                 830         
Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu Cys Glu Val Val Asp His
        835                 840                 845             
Val Phe Pro Leu Leu Lys Arg Ser His Ser Ser Asp Phe Pro Cys Ser
    850                 855                 860                 
Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg Glu Pro Leu Pro Pro Phe
865                 870                 875                 880 
Glu Asn Gln Asp Ile His Ser Ala Ser Ala
                885                 890 


<210> 7631
<211> 326
<212> PRT
<213> Homo sapiens

<400> 7631
Met Glu Tyr Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe
 1               5                  10                  15      
Tyr Lys Glu Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn
            20                  25                  30          
Thr Ile Ile Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Cys
        35                  40                  45              
Tyr Tyr Arg Cys His Ser Lys Cys Leu Asn Leu Ile Ser Lys Pro Cys
    50                  55                  60                  
Val Ser Ser Lys Val Ser His Gln Ala Glu Tyr Glu Leu Asn Ile Cys
65                  70                  75                  80  
Pro Glu Thr Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala Glu Cys Arg
                85                  90                  95      
Ala Pro Ile Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gln Cys Asp
            100                 105                 110         
Tyr Thr Gly Gln Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu Ala
        115                 120                 125             
Val Ile Pro Ala Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys
    130                 135                 140                 
Val Ser Arg Cys Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro
145                 150                 155                 160 
Val Leu Arg Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser Tyr Val Glu
                165                 170                 175     
Glu Leu Val Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu Leu Met Lys
            180                 185                 190         
Pro Tyr Phe Ile Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu
        195                 200                 205             
Gln Leu Gln Asp Arg Gln His Phe Val Glu Asn Asp Glu Met Tyr Ser
    210                 215                 220                 
Val Gln Asp Leu Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu
225                 230                 235                 240 
Thr Glu Ile His Thr Leu Phe Ala Lys His Ile Lys Leu Asp Cys Glu
                245                 250                 255     
Arg Cys Gln Ala Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp
            260                 265                 270         
Val Leu Phe Pro Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser
        275                 280                 285             
Ala Val Phe His Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro
    290                 295                 300                 
Lys Cys Ala Arg Leu Ser Leu Arg Lys Gln Ser Leu Phe Gln Glu Pro
305                 310                 315                 320 
Gly Pro Asp Val Glu Ala
                325     


<210> 7632
<211> 2111
<212> PRT
<213> Homo sapiens

<400> 7632
Glu Gly Gln Glu Gly Thr Gly Arg Trp Gln Gln Gly Ser Pro Ala Gly
 1               5                  10                  15      
Ala Arg Pro Arg Glu Trp Arg Arg Asp Thr His Gly Phe Pro Gly Pro
            20                  25                  30          
Ala Ala Ala Leu Thr Ser Ala Ser Arg Ser Gly Thr Arg Arg Val Arg
        35                  40                  45              
Asp Cys Ala Gly Thr Met Asp Asn Phe Phe Thr Glu Gly Thr Arg Val
    50                  55                  60                  
Trp Leu Arg Glu Asn Gly Gln His Phe Pro Ser Thr Val Asn Ser Cys
65                  70                  75                  80  
Ala Glu Gly Ile Val Val Phe Arg Thr Asp Tyr Gly Gln Val Phe Thr
                85                  90                  95      
Tyr Lys Gln Ser Thr Ile Thr His Gln Lys Val Thr Ala Met His Pro
            100                 105                 110         
Thr Asn Glu Glu Gly Val Asp Asp Met Ala Ser Leu Thr Glu Leu His
        115                 120                 125             
Gly Gly Ser Ile Met Tyr Asn Leu Phe Gln Arg Tyr Lys Arg Asn Gln
    130                 135                 140                 
Ile Tyr Thr Tyr Ile Gly Ser Ile Leu Ala Ser Val Asn Pro Tyr Gln
145                 150                 155                 160 
Pro Ile Ala Gly Leu Tyr Glu Pro Ala Thr Met Glu Gln Tyr Ser Arg
                165                 170                 175     
Arg His Leu Gly Glu Leu Pro Pro His Ile Phe Ala Ile Ala Asn Glu
            180                 185                 190         
Cys Tyr Arg Cys Leu Trp Lys Arg His Asp Asn Gln Cys Ile Leu Ile
        195                 200                 205             
Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu
    210                 215                 220                 
Lys Phe Leu Ser Val Ile Ser Gln Gln Ser Leu Glu Leu Ser Leu Lys
225                 230                 235                 240 
Glu Lys Thr Ser Cys Val Glu Arg Ala Ile Leu Glu Ser Ser Pro Ile
                245                 250                 255     
Met Glu Ala Phe Gly Asn Ala Lys Thr Val Tyr Asn Asn Asn Ser Ser
            260                 265                 270         
Arg Phe Gly Lys Phe Val Gln Leu Asn Ile Cys Gln Lys Gly Asn Ile
        275                 280                 285             
Gln Gly Gly Arg Ile Val Asp Tyr Leu Leu Glu Lys Asn Arg Val Val
    290                 295                 300                 
Arg Gln Asn Pro Gly Glu Arg Asn Tyr His Ile Phe Tyr Ala Leu Leu
305                 310                 315                 320 
Ala Gly Leu Glu His Glu Glu Arg Glu Glu Phe Tyr Leu Ser Thr Pro
                325                 330                 335     
Glu Asn Tyr His Tyr Leu Asn Gln Ser Gly Cys Val Glu Asp Lys Thr
            340                 345                 350         
Ile Ser Asp Gln Glu Ser Phe Arg Glu Val Ile Thr Ala Met Asp Val
        355                 360                 365             
Met Gln Phe Ser Lys Glu Glu Val Arg Glu Val Ser Arg Leu Leu Ala
    370                 375                 380                 
Gly Ile Leu His Leu Gly Asn Ile Glu Phe Ile Thr Ala Gly Gly Ala
385                 390                 395                 400 
Gln Val Ser Phe Lys Thr Ala Leu Gly Arg Ser Ala Glu Leu Leu Gly
                405                 410                 415     
Leu Asp Pro Thr Gln Leu Thr Asp Ala Leu Thr Gln Arg Ser Met Phe
            420                 425                 430         
Leu Arg Gly Glu Glu Ile Leu Thr Pro Leu Asn Val Gln Gln Ala Val
        435                 440                 445             
Asp Ser Arg Asp Ser Leu Ala Met Ala Leu Tyr Ala Cys Cys Phe Glu
    450                 455                 460                 
Trp Val Ile Lys Lys Ile Asn Ser Arg Ile Lys Gly Asn Glu Asp Phe
465                 470                 475                 480 
Lys Ser Ile Gly Ile Leu Asp Ile Phe Gly Phe Glu Asn Phe Glu Val
                485                 490                 495     
Asn His Phe Glu Gln Phe Asn Ile Asn Tyr Ala Asn Glu Lys Leu Gln
            500                 505                 510         
Glu Tyr Phe Asn Lys His Ile Phe Ser Leu Glu Gln Leu Glu Tyr Ser
        515                 520                 525             
Arg Glu Gly Leu Val Trp Glu Asp Ile Asp Trp Ile Asp Asn Gly Glu
    530                 535                 540                 
Cys Leu Asp Leu Ile Glu Lys Lys Leu Gly Leu Leu Ala Leu Ile Asn
545                 550                 555                 560 
Glu Glu Ser His Phe Pro Gln Ala Thr Asp Ser Thr Leu Leu Glu Lys
                565                 570                 575     
Leu His Ser Gln His Ala Asn Asn His Phe Tyr Val Lys Pro Arg Val
            580                 585                 590         
Ala Val Asn Asn Phe Gly Val Lys His Tyr Ala Gly Glu Val Gln Tyr
        595                 600                 605             
Asp Val Arg Gly Ile Leu Glu Lys Asn Arg Asp Thr Phe Arg Asp Asp
    610                 615                 620                 
Leu Leu Asn Leu Leu Arg Glu Ser Arg Phe Asp Phe Ile Tyr Asp Leu
625                 630                 635                 640 
Phe Glu His Val Ser Ser Arg Asn Asn Gln Asp Thr Leu Lys Cys Gly
                645                 650                 655     
Ser Lys His Arg Arg Pro Thr Val Ser Ser Gln Phe Lys Asp Ser Leu
            660                 665                 670         
His Ser Leu Met Ala Thr Leu Ser Ser Ser Asn Pro Phe Phe Val Arg
        675                 680                 685             
Cys Ile Lys Pro Asn Met Gln Lys Met Pro Asp Gln Phe Asp Gln Ala
    690                 695                 700                 
Val Val Leu Asn Gln Leu Arg Tyr Ser Gly Met Leu Glu Thr Val Arg
705                 710                 715                 720 
Ile Arg Lys Ala Gly Tyr Ala Val Arg Arg Pro Phe Gln Asp Phe Tyr
                725                 730                 735     
Lys Arg Tyr Lys Val Leu Met Arg Asn Leu Ala Leu Pro Glu Asp Val
            740                 745                 750         
Arg Gly Lys Cys Thr Ser Leu Leu Gln Leu Tyr Asp Ala Ser Asn Ser
        755                 760                 765             
Glu Trp Gln Leu Gly Lys Thr Lys Val Phe Leu Arg Glu Ser Leu Glu
    770                 775                 780                 
Gln Lys Leu Glu Lys Arg Arg Glu Glu Glu Val Ser His Ala Ala Met
785                 790                 795                 800 
Val Ile Arg Ala His Val Leu Gly Phe Leu Ala Arg Lys Gln Tyr Arg
                805                 810                 815     
Lys Val Leu Tyr Cys Val Val Ile Ile Gln Lys Asn Tyr Arg Ala Phe
            820                 825                 830         
Leu Leu Arg Arg Arg Phe Leu His Leu Lys Lys Ala Ala Ile Val Phe
        835                 840                 845             
Gln Lys Gln Leu Arg Gly Gln Ile Ala Arg Arg Val Tyr Arg Gln Leu
    850                 855                 860                 
Leu Ala Glu Lys Arg Glu Gln Glu Glu Lys Lys Lys Gln Glu Glu Glu
865                 870                 875                 880 
Glu Lys Lys Lys Arg Glu Glu Glu Glu Arg Glu Arg Glu Arg Glu Arg
                885                 890                 895     
Arg Glu Ala Glu Leu Arg Ala Gln Gln Glu Glu Glu Thr Arg Lys Gln
            900                 905                 910         
Gln Glu Leu Glu Ala Leu Gln Lys Ser Gln Lys Glu Ala Glu Leu Thr
        915                 920                 925             
Arg Glu Leu Glu Lys Gln Lys Glu Asn Lys Gln Val Glu Glu Ile Leu
    930                 935                 940                 
Arg Leu Glu Lys Glu Ile Glu Asp Leu Gln Arg Met Lys Glu Gln Gln
945                 950                 955                 960 
Glu Leu Ser Leu Thr Glu Ala Ser Leu Gln Lys Leu Gln Glu Arg Arg
                965                 970                 975     
Asp Gln Glu Leu Arg Arg Leu Glu Glu Glu Ala Cys Arg Ala Ala Gln
            980                 985                 990         
Glu Phe Leu Glu Ser Leu Asn Phe Asp Glu Ile Asp Glu Cys Val Arg
        995                 1000                1005            
Asn Ile Glu Arg Ser Leu Ser Val Gly Ser Glu Phe Ser Ser Glu Leu
    1010                1015                1020                
Ala Glu Ser Ala Cys Glu Glu Lys Pro Asn Phe Asn Phe Ser Gln Pro
1025                1030                1035                1040
Tyr Pro Glu Glu Glu Val Asp Glu Gly Phe Glu Ala Asp Asp Asp Ala
                1045                1050                1055    
Phe Lys Asp Ser Pro Asn Pro Ser Glu His Gly His Ser Asp Gln Arg
            1060                1065                1070        
Thr Ser Gly Ile Arg Thr Ser Asp Asp Ser Ser Glu Glu Asp Pro Tyr
        1075                1080                1085            
Met Asn Asp Thr Val Val Pro Thr Ser Pro Ser Ala Asp Ser Thr Val
    1090                1095                1100                
Leu Leu Ala Pro Ser Val Gln Asp Ser Gly Ser Leu His Asn Ser Ser
1105                1110                1115                1120
Ser Gly Glu Ser Thr Tyr Cys Met Pro Gln Asn Ala Gly Asp Leu Pro
                1125                1130                1135    
Ser Pro Asp Gly Asp Tyr Asp Tyr Asp Gln Asp Asp Tyr Glu Asp Gly
            1140                1145                1150        
Ala Ile Thr Ser Gly Ser Ser Val Thr Phe Ser Asn Ser Tyr Gly Ser
        1155                1160                1165            
Gln Trp Ser Pro Asp Tyr Arg Cys Ser Val Gly Thr Tyr Asn Ser Ser
    1170                1175                1180                
Gly Ala Tyr Arg Phe Ser Ser Glu Gly Ala Gln Ser Ser Phe Glu Asp
1185                1190                1195                1200
Ser Glu Glu Asp Phe Asp Ser Arg Phe Asp Thr Asp Asp Glu Leu Ser
                1205                1210                1215    
Tyr Arg Arg Asp Ser Val Tyr Ser Cys Val Thr Leu Pro Tyr Phe His
            1220                1225                1230        
Ser Phe Leu Tyr Met Lys Gly Gly Leu Met Asn Ser Trp Lys Arg Arg
        1235                1240                1245            
Trp Cys Val Leu Lys Asp Glu Thr Phe Leu Trp Phe Arg Ser Lys Gln
    1250                1255                1260                
Glu Ala Leu Lys Gln Gly Trp Leu His Lys Lys Gly Gly Gly Ser Ser
1265                1270                1275                1280
Thr Leu Ser Arg Arg Asn Trp Lys Lys Arg Trp Phe Val Leu Arg Gln
                1285                1290                1295    
Ser Lys Leu Met Tyr Phe Glu Asn Asp Ser Glu Glu Lys Leu Lys Gly
            1300                1305                1310        
Thr Val Glu Val Arg Thr Ala Lys Glu Ile Ile Asp Asn Thr Thr Lys
        1315                1320                1325            
Glu Asn Gly Ile Asp Ile Ile Met Ala Asp Arg Thr Phe His Leu Ile
    1330                1335                1340                
Ala Glu Ser Pro Glu Asp Ala Ser Gln Trp Phe Ser Val Leu Ser Gln
1345                1350                1355                1360
Val His Ala Ser Thr Asp Gln Glu Ile Gln Glu Met His Asp Glu Gln
                1365                1370                1375    
Ala Asn Pro Gln Asn Ala Val Gly Thr Leu Asp Val Gly Leu Ile Asp
            1380                1385                1390        
Ser Val Cys Ala Ser Asp Ser Pro Asp Arg Pro Asn Ser Phe Val Ile
        1395                1400                1405            
Ile Thr Ala Asn Arg Val Leu His Cys Asn Ala Asp Thr Pro Glu Glu
    1410                1415                1420                
Met His His Trp Ile Thr Leu Leu Gln Arg Ser Lys Gly Asp Thr Arg
1425                1430                1435                1440
Val Glu Gly Gln Glu Phe Ile Val Arg Gly Trp Leu His Lys Glu Val
                1445                1450                1455    
Lys Asn Ser Pro Lys Met Ser Ser Leu Lys Leu Lys Lys Arg Trp Phe
            1460                1465                1470        
Val Leu Thr His Asn Ser Leu Asp Tyr Tyr Lys Ser Ser Glu Lys Asn
        1475                1480                1485            
Ala Leu Lys Leu Gly Thr Leu Val Leu Asn Ser Leu Cys Ser Val Val
    1490                1495                1500                
Pro Pro Asp Glu Lys Ile Phe Lys Glu Thr Gly Tyr Trp Asn Val Thr
1505                1510                1515                1520
Val Tyr Gly Arg Lys His Cys Tyr Arg Leu Tyr Thr Lys Leu Leu Asn
                1525                1530                1535    
Glu Ala Thr Arg Trp Ser Ser Ala Ile Gln Asn Val Thr Asp Thr Lys
            1540                1545                1550        
Ala Pro Ile Asp Thr Pro Thr Gln Gln Leu Ile Gln Asp Ile Lys Glu
        1555                1560                1565            
Asn Cys Leu Asn Ser Asp Val Val Glu Gln Ile Tyr Lys Arg Asn Pro
    1570                1575                1580                
Ile Leu Arg Tyr Thr His His Pro Leu His Ser Pro Leu Leu Pro Leu
1585                1590                1595                1600
Pro Tyr Gly Asp Ile Asn Leu Asn Leu Leu Lys Asp Lys Gly Tyr Thr
                1605                1610                1615    
Thr Leu Gln Asp Glu Ala Ile Lys Ile Phe Asn Ser Leu Gln Gln Leu
            1620                1625                1630        
Glu Ser Met Ser Asp Pro Ile Pro Ile Ile Gln Gly Ile Leu Gln Thr
        1635                1640                1645            
Gly His Asp Leu Arg Pro Leu Arg Asp Glu Leu Tyr Cys Gln Leu Ile
    1650                1655                1660                
Lys Gln Thr Asn Lys Val Pro His Pro Gly Ser Val Gly Asn Leu Tyr
1665                1670                1675                1680
Ser Trp Gln Ile Leu Thr Cys Leu Ser Cys Thr Phe Leu Pro Ser Arg
                1685                1690                1695    
Gly Ile Leu Lys Tyr Leu Lys Phe His Leu Lys Arg Ile Arg Glu Gln
            1700                1705                1710        
Phe Pro Gly Thr Glu Met Glu Lys Tyr Ala Leu Phe Thr Tyr Glu Ser
        1715                1720                1725            
Leu Lys Lys Thr Lys Cys Arg Glu Phe Val Pro Ser Arg Asp Glu Ile
    1730                1735                1740                
Glu Ala Leu Ile His Arg Gln Glu Met Thr Ser Thr Val Tyr Cys His
1745                1750                1755                1760
Gly Gly Gly Ser Cys Lys Ile Thr Ile Asn Ser His Thr Thr Ala Gly
                1765                1770                1775    
Glu Val Val Glu Lys Leu Ile Arg Gly Leu Ala Met Glu Asp Ser Arg
            1780                1785                1790        
Asn Met Phe Ala Leu Phe Glu Tyr Asn Gly His Val Asp Lys Ala Ile
        1795                1800                1805            
Glu Ser Arg Thr Val Val Ala Asp Val Leu Ala Lys Phe Glu Lys Leu
    1810                1815                1820                
Ala Ala Thr Ser Glu Val Gly Asp Leu Pro Trp Lys Phe Tyr Phe Lys
1825                1830                1835                1840
Leu Tyr Cys Phe Leu Asp Thr Asp Asn Val Pro Lys Asp Ser Val Glu
                1845                1850                1855    
Phe Ala Phe Met Phe Glu Gln Ala His Glu Ala Val Ile His Gly His
            1860                1865                1870        
His Pro Ala Pro Glu Glu Asn Leu Gln Val Leu Ala Ala Leu Arg Leu
        1875                1880                1885            
Gln Tyr Leu Gln Gly Asp Tyr Thr Leu His Ala Ala Ile Pro Pro Leu
    1890                1895                1900                
Glu Glu Val Tyr Ser Leu Gln Arg Leu Lys Ala Arg Ile Ser Gln Ser
1905                1910                1915                1920
Thr Lys Thr Phe Thr Pro Cys Glu Arg Leu Glu Lys Arg Arg Thr Ser
                1925                1930                1935    
Phe Leu Glu Gly Thr Leu Arg Arg Ser Phe Arg Thr Gly Ser Val Val
            1940                1945                1950        
Arg Gln Lys Val Glu Glu Glu Gln Met Leu Asp Met Trp Ile Lys Glu
        1955                1960                1965            
Glu Val Ser Ser Ala Arg Ala Ser Ile Ile Asp Lys Trp Arg Lys Phe
    1970                1975                1980                
Gln Gly Met Asn Gln Glu Gln Ala Met Ala Lys Tyr Met Ala Leu Ile
1985                1990                1995                2000
Lys Glu Trp Pro Gly Tyr Gly Ser Thr Leu Phe Asp Val Glu Cys Lys
                2005                2010                2015    
Glu Gly Gly Phe Pro Gln Glu Leu Trp Leu Gly Val Ser Ala Asp Ala
            2020                2025                2030        
Val Ser Val Tyr Lys Arg Gly Glu Gly Arg Pro Leu Glu Val Phe Gln
        2035                2040                2045            
Tyr Glu His Ile Leu Ser Phe Gly Ala Pro Leu Ala Asn Thr Tyr Lys
    2050                2055                2060                
Ile Val Val Asp Glu Arg Glu Leu Leu Phe Glu Thr Ser Glu Val Val
2065                2070                2075                2080
Asp Val Ala Lys Leu Met Lys Ala Tyr Ile Ser Met Ile Val Lys Lys
                2085                2090                2095    
Arg Tyr Ser Thr Thr Arg Ser Ala Ser Ser Gln Gly Ser Ser Arg
            2100                2105                2110    


<210> 7633
<211> 2058
<212> PRT
<213> Homo sapiens

<400> 7633
Met Asp Asn Phe Phe Thr Glu Gly Thr Arg Val Trp Leu Arg Glu Asn
 1               5                  10                  15      
Gly Gln His Phe Pro Ser Thr Val Asn Ser Cys Ala Glu Gly Ile Val
            20                  25                  30          
Val Phe Arg Thr Asp Tyr Gly Gln Val Phe Thr Tyr Lys Gln Ser Thr
        35                  40                  45              
Ile Thr His Gln Lys Val Thr Ala Met His Pro Thr Asn Glu Glu Gly
    50                  55                  60                  
Val Asp Asp Met Ala Ser Leu Thr Glu Leu His Gly Gly Ser Ile Met
65                  70                  75                  80  
Tyr Asn Leu Phe Gln Arg Tyr Lys Arg Asn Gln Ile Tyr Thr Tyr Ile
                85                  90                  95      
Gly Ser Ile Leu Ala Ser Val Asn Pro Tyr Gln Pro Ile Ala Gly Leu
            100                 105                 110         
Tyr Glu Pro Ala Thr Met Glu Gln Tyr Ser Arg Arg His Leu Gly Glu
        115                 120                 125             
Leu Pro Pro His Ile Phe Ala Ile Ala Asn Glu Cys Tyr Arg Cys Leu
    130                 135                 140                 
Trp Lys Arg His Asp Asn Gln Cys Ile Leu Ile Ser Gly Glu Ser Gly
145                 150                 155                 160 
Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Lys Phe Leu Ser Val
                165                 170                 175     
Ile Ser Gln Gln Ser Leu Glu Leu Ser Leu Lys Glu Lys Thr Ser Cys
            180                 185                 190         
Val Glu Arg Ala Ile Leu Glu Ser Ser Pro Ile Met Glu Ala Phe Gly
        195                 200                 205             
Asn Ala Lys Thr Val Tyr Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe
    210                 215                 220                 
Val Gln Leu Asn Ile Cys Gln Lys Gly Asn Ile Gln Gly Gly Arg Ile
225                 230                 235                 240 
Val Asp Tyr Leu Leu Glu Lys Asn Arg Val Val Arg Gln Asn Pro Gly
                245                 250                 255     
Glu Arg Asn Tyr His Ile Phe Tyr Ala Leu Leu Ala Gly Leu Glu His
            260                 265                 270         
Glu Glu Arg Glu Glu Phe Tyr Leu Ser Thr Pro Glu Asn Tyr His Tyr
        275                 280                 285             
Leu Asn Gln Ser Gly Cys Val Glu Asp Lys Thr Ile Ser Asp Gln Glu
    290                 295                 300                 
Ser Phe Arg Glu Val Ile Thr Ala Met Asp Val Met Gln Phe Ser Lys
305                 310                 315                 320 
Glu Glu Val Trp Glu Val Ser Arg Leu Leu Ala Gly Ile Leu His Leu
                325                 330                 335     
Gly Asn Ile Glu Phe Ile Thr Ala Gly Gly Ala Gln Val Ser Phe Lys
            340                 345                 350         
Thr Ala Leu Gly Arg Ser Ala Glu Leu Leu Gly Leu Asp Pro Thr Gln
        355                 360                 365             
Leu Thr Asp Ala Leu Thr Gln Arg Ser Met Phe Leu Arg Gly Glu Glu
    370                 375                 380                 
Ile Leu Thr Pro Leu Asn Val Gln Gln Ala Val Asp Ser Arg Asp Ser
385                 390                 395                 400 
Leu Ala Met Ala Leu Tyr Ala Cys Cys Phe Glu Trp Val Ile Lys Lys
                405                 410                 415     
Ile Asn Ser Arg Ile Lys Gly Asn Glu Asp Phe Lys Ser Ile Gly Ile
            420                 425                 430         
Leu Asp Ile Phe Gly Phe Glu Asn Phe Glu Val Asn His Phe Glu Gln
        435                 440                 445             
Phe Asn Ile Asn Tyr Ala Asn Glu Lys Leu Gln Glu Tyr Phe Asn Lys
    450                 455                 460                 
His Ile Phe Ser Leu Glu Gln Leu Glu Tyr Ser Arg Glu Gly Leu Val
465                 470                 475                 480 
Trp Glu Asp Ile Asp Trp Ile Asp Asn Gly Glu Cys Leu Asp Leu Ile
                485                 490                 495     
Glu Lys Lys Leu Gly Leu Leu Ala Leu Ile Asn Glu Glu Ser His Phe
            500                 505                 510         
Pro Gln Ala Thr Asp Ser Thr Leu Leu Glu Lys Leu His Ser Gln His
        515                 520                 525             
Ala Asn Asn His Phe Tyr Val Lys Pro Arg Val Ala Val Asn Asn Phe
    530                 535                 540                 
Gly Val Lys His Tyr Ala Gly Glu Val Gln Tyr Asp Val Arg Gly Ile
545                 550                 555                 560 
Leu Glu Lys Asn Arg Asp Thr Phe Arg Asp Asp Leu Leu Asn Leu Leu
                565                 570                 575     
Arg Glu Ser Arg Phe Asp Phe Ile Tyr Asp Leu Phe Glu His Val Ser
            580                 585                 590         
Ser Arg Asn Asn Gln Asp Thr Leu Lys Cys Gly Ser Lys His Arg Arg
        595                 600                 605             
Pro Thr Val Ser Ser Gln Phe Lys Asp Ser Leu His Ser Leu Met Ala
    610                 615                 620                 
Thr Leu Ser Ser Ser Asn Pro Phe Phe Val Arg Cys Ile Lys Pro Asn
625                 630                 635                 640 
Met Gln Lys Met Pro Asp Gln Phe Asp Gln Ala Val Val Leu Asn Gln
                645                 650                 655     
Leu Arg Tyr Ser Gly Met Leu Glu Thr Val Arg Ile Arg Lys Ala Gly
            660                 665                 670         
Tyr Ala Val Arg Arg Pro Phe Gln Asp Phe Tyr Lys Arg Tyr Lys Val
        675                 680                 685             
Leu Met Arg Asn Leu Ala Leu Pro Glu Asp Val Arg Gly Lys Cys Thr
    690                 695                 700                 
Ser Leu Leu Gln Leu Tyr Asp Ala Ser Asn Ser Glu Trp Gln Leu Gly
705                 710                 715                 720 
Lys Thr Lys Val Phe Leu Arg Glu Ser Leu Glu Gln Lys Leu Glu Lys
                725                 730                 735     
Arg Arg Glu Glu Glu Val Ser His Ala Ala Met Val Ile Arg Ala His
            740                 745                 750         
Val Leu Gly Phe Leu Ala Arg Lys Gln Tyr Arg Lys Val Leu Tyr Cys
        755                 760                 765             
Val Val Ile Ile Gln Lys Asn Tyr Arg Ala Phe Leu Leu Arg Arg Arg
    770                 775                 780                 
Phe Leu His Leu Lys Lys Ala Ala Ile Val Phe Gln Lys Gln Leu Arg
785                 790                 795                 800 
Gly Gln Ile Ala Arg Arg Val Tyr Arg Gln Leu Leu Ala Glu Lys Arg
                805                 810                 815     
Glu Gln Glu Glu Lys Lys Lys Gln Glu Glu Glu Glu Lys Lys Lys Arg
            820                 825                 830         
Glu Glu Glu Glu Arg Glu Arg Glu Arg Glu Arg Arg Glu Ala Glu Leu
        835                 840                 845             
Arg Ala Gln Gln Glu Glu Glu Thr Arg Lys Gln Gln Glu Leu Glu Ala
    850                 855                 860                 
Leu Gln Lys Ser Gln Lys Glu Ala Glu Leu Thr Arg Glu Leu Glu Lys
865                 870                 875                 880 
Gln Lys Glu Asn Lys Gln Val Glu Glu Ile Leu Arg Leu Glu Lys Glu
                885                 890                 895     
Ile Glu Asp Leu Gln Arg Met Lys Glu Gln Gln Glu Leu Ser Leu Thr
            900                 905                 910         
Glu Ala Ser Leu Gln Lys Leu Gln Glu Arg Arg Asp Gln Glu Leu Arg
        915                 920                 925             
Arg Leu Glu Glu Glu Ala Cys Arg Ala Ala Gln Glu Phe Leu Glu Ser
    930                 935                 940                 
Leu Asn Phe Asp Glu Ile Asp Glu Cys Val Arg Asn Ile Glu Arg Ser
945                 950                 955                 960 
Leu Ser Val Gly Ser Glu Phe Ser Ser Glu Leu Ala Glu Ser Ala Cys
                965                 970                 975     
Glu Glu Lys Pro Asn Phe Asn Phe Ser Gln Pro Tyr Pro Glu Glu Glu
            980                 985                 990         
Val Asp Glu Gly Phe Glu Ala Asp Asp Asp Ala Phe Lys Asp Ser Pro
        995                 1000                1005            
Asn Pro Ser Glu His Gly His Ser Asp Gln Arg Thr Ser Gly Ile Arg
    1010                1015                1020                
Thr Ser Asp Asp Ser Ser Glu Glu Asp Pro Tyr Met Asn Asp Thr Val
1025                1030                1035                1040
Val Pro Thr Ser Pro Ser Ala Asp Ser Thr Val Leu Leu Ala Pro Ser
                1045                1050                1055    
Val Gln Asp Ser Gly Ser Leu His Asn Ser Ser Ser Gly Glu Ser Thr
            1060                1065                1070        
Tyr Cys Met Pro Gln Asn Ala Gly Asp Leu Pro Ser Pro Asp Gly Asp
        1075                1080                1085            
Tyr Asp Tyr Asp Gln Asp Asp Tyr Glu Asp Gly Ala Ile Thr Ser Gly
    1090                1095                1100                
Ser Ser Val Thr Phe Ser Asn Ser Tyr Gly Ser Gln Trp Ser Pro Asp
1105                1110                1115                1120
Tyr Arg Cys Ser Val Gly Thr Tyr Asn Ser Ser Gly Ala Tyr Arg Phe
                1125                1130                1135    
Ser Ser Glu Gly Ala Gln Ser Ser Phe Glu Asp Ser Glu Glu Asp Phe
            1140                1145                1150        
Asp Ser Arg Phe Asp Thr Asp Asp Glu Leu Ser Tyr Arg Arg Asp Ser
        1155                1160                1165            
Val Tyr Ser Cys Val Thr Leu Pro Tyr Phe His Ser Phe Leu Tyr Met
    1170                1175                1180                
Lys Gly Gly Leu Met Asn Ser Trp Lys Arg Arg Trp Cys Val Leu Lys
1185                1190                1195                1200
Asp Glu Thr Phe Leu Trp Phe Arg Ser Lys Gln Glu Ala Leu Lys Gln
                1205                1210                1215    
Gly Trp Leu His Lys Lys Gly Gly Gly Ser Ser Thr Leu Ser Arg Arg
            1220                1225                1230        
Asn Trp Lys Lys Arg Trp Phe Val Leu Arg Gln Ser Lys Leu Met Tyr
        1235                1240                1245            
Phe Glu Asn Asp Ser Glu Glu Lys Leu Lys Gly Thr Val Glu Val Arg
    1250                1255                1260                
Thr Ala Lys Glu Ile Ile Asp Asn Thr Thr Lys Glu Asn Gly Ile Asp
1265                1270                1275                1280
Ile Ile Met Ala Asp Arg Thr Phe His Leu Ile Ala Glu Ser Pro Glu
                1285                1290                1295    
Asp Ala Ser Gln Trp Phe Ser Val Leu Ser Gln Val His Ala Ser Thr
            1300                1305                1310        
Asp Gln Glu Ile Gln Glu Met His Asp Glu Gln Ala Asn Pro Gln Asn
        1315                1320                1325            
Ala Val Gly Thr Leu Asp Val Gly Leu Ile Asp Ser Val Cys Ala Ser
    1330                1335                1340                
Asp Ser Pro Asp Arg Pro Asn Ser Phe Val Ile Ile Thr Ala Asn Arg
1345                1350                1355                1360
Val Leu His Cys Asn Ala Asp Thr Pro Glu Glu Met His His Trp Ile
                1365                1370                1375    
Thr Leu Leu Gln Arg Ser Lys Gly Asp Thr Arg Val Glu Gly Gln Glu
            1380                1385                1390        
Phe Ile Val Arg Gly Trp Leu His Lys Glu Val Lys Asn Ser Pro Lys
        1395                1400                1405            
Met Ser Ser Leu Lys Leu Lys Lys Arg Trp Phe Val Leu Thr His Asn
    1410                1415                1420                
Ser Leu Asp Tyr Tyr Lys Ser Ser Glu Lys Asn Ala Leu Lys Leu Gly
1425                1430                1435                1440
Thr Leu Val Leu Asn Ser Leu Cys Ser Val Val Pro Pro Asp Glu Lys
                1445                1450                1455    
Ile Phe Lys Glu Thr Gly Tyr Trp Asn Val Thr Val Tyr Gly Arg Lys
            1460                1465                1470        
His Cys Tyr Arg Leu Tyr Thr Lys Leu Leu Asn Glu Ala Thr Arg Trp
        1475                1480                1485            
Ser Ser Ala Ile Gln Asn Val Thr Asp Thr Lys Ala Pro Ile Asp Thr
    1490                1495                1500                
Pro Thr Gln Gln Leu Ile Gln Asp Ile Lys Glu Asn Cys Leu Asn Ser
1505                1510                1515                1520
Asp Val Val Glu Gln Ile Tyr Lys Arg Asn Pro Ile Leu Arg Tyr Thr
                1525                1530                1535    
His His Pro Leu His Ser Pro Leu Leu Pro Leu Pro Tyr Gly Asp Ile
            1540                1545                1550        
Asn Leu Asn Leu Leu Lys Asp Lys Gly Tyr Thr Thr Leu Gln Asp Glu
        1555                1560                1565            
Ala Ile Lys Ile Phe Asn Ser Leu Gln Gln Leu Glu Ser Met Ser Asp
    1570                1575                1580                
Pro Ile Pro Ile Ile Gln Gly Ile Leu Gln Thr Gly His Asp Leu Arg
1585                1590                1595                1600
Pro Leu Arg Asp Glu Leu Tyr Cys Gln Leu Ile Lys Gln Thr Asn Lys
                1605                1610                1615    
Val Pro His Pro Gly Ser Val Gly Asn Leu Tyr Ser Trp Gln Ile Leu
            1620                1625                1630        
Thr Cys Leu Ser Cys Thr Phe Leu Pro Ser Arg Gly Ile Leu Lys Tyr
        1635                1640                1645            
Leu Lys Phe His Leu Lys Arg Ile Arg Glu Gln Phe Pro Gly Thr Glu
    1650                1655                1660                
Met Glu Lys Tyr Ala Leu Phe Thr Tyr Glu Ser Leu Lys Lys Thr Lys
1665                1670                1675                1680
Cys Arg Glu Phe Val Pro Ser Arg Asp Glu Ile Glu Ala Leu Ile His
                1685                1690                1695    
Arg Gln Glu Met Thr Ser Thr Val Tyr Cys His Gly Gly Gly Ser Cys
            1700                1705                1710        
Lys Ile Thr Ile Asn Ser His Thr Thr Ala Gly Glu Val Val Glu Lys
        1715                1720                1725            
Leu Ile Arg Gly Leu Ala Met Glu Asp Ser Arg Asn Met Phe Ala Leu
    1730                1735                1740                
Phe Glu Tyr Asn Gly His Val Asp Lys Ala Ile Glu Ser Arg Thr Val
1745                1750                1755                1760
Val Ala Asp Val Leu Ala Lys Phe Glu Lys Leu Ala Ala Thr Ser Glu
                1765                1770                1775    
Val Gly Asp Leu Pro Trp Lys Phe Tyr Phe Lys Leu Tyr Cys Phe Leu
            1780                1785                1790        
Asp Thr Asp Asn Val Pro Lys Asp Ser Val Glu Phe Ala Phe Met Phe
        1795                1800                1805            
Glu Gln Ala His Glu Ala Val Ile His Gly His His Pro Ala Pro Glu
    1810                1815                1820                
Glu Asn Leu Gln Val Leu Ala Ala Leu Arg Leu Gln Tyr Leu Gln Gly
1825                1830                1835                1840
Asp Tyr Thr Leu His Ala Ala Ile Pro Pro Leu Glu Glu Val Tyr Ser
                1845                1850                1855    
Leu Gln Arg Leu Lys Ala Arg Ile Ser Gln Ser Thr Lys Thr Phe Thr
            1860                1865                1870        
Pro Cys Glu Arg Leu Glu Lys Arg Arg Thr Ser Phe Leu Glu Gly Thr
        1875                1880                1885            
Leu Arg Arg Ser Phe Arg Thr Gly Ser Val Val Arg Gln Lys Val Glu
    1890                1895                1900                
Glu Glu Gln Met Leu Asp Met Trp Ile Lys Glu Glu Val Ser Ser Ala
1905                1910                1915                1920
Arg Ala Ser Ile Ile Asp Lys Trp Arg Lys Phe Gln Gly Met Asn Gln
                1925                1930                1935    
Glu Gln Ala Met Ala Lys Tyr Met Ala Leu Ile Lys Glu Trp Pro Gly
            1940                1945                1950        
Tyr Gly Ser Thr Leu Phe Asp Val Glu Cys Lys Glu Gly Gly Phe Pro
        1955                1960                1965            
Gln Glu Leu Trp Leu Gly Val Ser Ala Asp Ala Val Ser Val Tyr Lys
    1970                1975                1980                
Arg Gly Glu Gly Arg Pro Leu Glu Val Phe Gln Tyr Glu His Ile Leu
1985                1990                1995                2000
Ser Phe Gly Ala Pro Leu Ala Asn Thr Tyr Lys Ile Val Val Asp Glu
                2005                2010                2015    
Arg Glu Leu Leu Phe Glu Thr Ser Glu Val Val Asp Val Ala Lys Leu
            2020                2025                2030        
Met Lys Ala Tyr Ile Ser Met Ile Val Lys Lys Arg Tyr Ser Thr Thr
        2035                2040                2045            
Arg Ser Ala Ser Ser Gln Gly Ser Ser Arg
    2050                2055            


<210> 7634
<211> 1223
<212> PRT
<213> Homo sapiens

<400> 7634
Met Arg Ser Arg Ser Asn Ser Gly Val Arg Leu Asp Gly Tyr Ala Arg
 1               5                  10                  15      
Leu Val Gln Gln Thr Ile Leu Cys His Gln Asn Pro Val Thr Gly Leu
            20                  25                  30          
Leu Pro Ala Ser Tyr Asp Gln Lys Asp Ala Trp Val Arg Asp Asn Val
        35                  40                  45              
Tyr Ser Ile Leu Ala Val Trp Gly Leu Gly Leu Ala Tyr Arg Lys Asn
    50                  55                  60                  
Ala Asp Arg Asp Glu Asp Lys Ala Lys Ala Tyr Glu Leu Glu Gln Ser
65                  70                  75                  80  
Val Val Lys Leu Met Arg Gly Leu Leu His Cys Met Ile Arg Gln Val
                85                  90                  95      
Asp Lys Val Glu Ser Phe Lys Tyr Ser Gln Ser Thr Lys Asp Ser Leu
            100                 105                 110         
His Ala Lys Tyr Asn Thr Lys Thr Cys Ala Thr Val Val Gly Asp Asp
        115                 120                 125             
Gln Trp Gly His Leu Gln Leu Asp Ala Thr Ser Val Tyr Leu Leu Phe
    130                 135                 140                 
Leu Ala Gln Met Thr Ala Ser Gly Leu His Ile Ile His Ser Leu Asp
145                 150                 155                 160 
Glu Val Asn Phe Ile Gln Asn Leu Val Phe Tyr Ile Glu Ala Ala Tyr
                165                 170                 175     
Lys Thr Ala Asp Phe Gly Ile Trp Glu Arg Gly Asp Lys Thr Asn Gln
            180                 185                 190         
Gly Ile Ser Glu Leu Asn Ala Ser Ser Val Gly Met Ala Lys Ala Ala
        195                 200                 205             
Leu Glu Ala Leu Asp Glu Leu Asp Leu Phe Gly Val Lys Gly Gly Pro
    210                 215                 220                 
Gln Ser Val Ile His Val Leu Ala Asp Glu Val Gln His Cys Gln Ser
225                 230                 235                 240 
Ile Leu Asn Ser Leu Leu Pro Arg Ala Ser Thr Ser Lys Glu Val Asp
                245                 250                 255     
Ala Ser Leu Leu Ser Val Val Ser Phe Pro Ala Phe Ala Val Glu Asp
            260                 265                 270         
Ser Gln Leu Val Glu Leu Thr Lys Gln Glu Ile Ile Thr Lys Leu Gln
        275                 280                 285             
Gly Arg Tyr Gly Cys Cys Arg Phe Leu Arg Asp Gly Tyr Lys Thr Pro
    290                 295                 300                 
Lys Glu Asp Pro Asn Arg Leu Tyr Tyr Glu Pro Ala Glu Leu Lys Leu
305                 310                 315                 320 
Phe Glu Asn Ile Glu Cys Glu Trp Pro Leu Phe Trp Thr Tyr Phe Ile
                325                 330                 335     
Leu Asp Gly Val Phe Ser Gly Asn Ala Glu Gln Val Gln Glu Tyr Lys
            340                 345                 350         
Glu Ala Leu Glu Ala Val Leu Ile Lys Gly Lys Asn Gly Val Pro Leu
        355                 360                 365             
Leu Pro Glu Leu Tyr Ser Val Pro Pro Asp Arg Val Asp Glu Glu Tyr
    370                 375                 380                 
Gln Asn Pro His Thr Val Asp Arg Val Pro Met Gly Lys Leu Pro His
385                 390                 395                 400 
Met Trp Gly Gln Ser Leu Tyr Ile Leu Gly Ser Leu Met Ala Glu Gly
                405                 410                 415     
Phe Leu Ala Pro Gly Glu Ile Asp Pro Leu Asn Arg Arg Phe Ser Thr
            420                 425                 430         
Val Pro Lys Pro Asp Val Val Val Gln Val Ser Ile Leu Ala Glu Thr
        435                 440                 445             
Glu Glu Ile Lys Thr Ile Leu Lys Asp Lys Gly Ile Tyr Val Glu Thr
    450                 455                 460                 
Ile Ala Glu Val Tyr Pro Ile Arg Val Gln Pro Ala Arg Ile Leu Ser
465                 470                 475                 480 
His Ile Tyr Ser Ser Leu Gly Cys Asn Asn Arg Met Lys Leu Ser Gly
                485                 490                 495     
Arg Pro Tyr Arg His Met Gly Val Leu Gly Thr Ser Lys Leu Tyr Asp
            500                 505                 510         
Ile Arg Lys Thr Ile Phe Thr Phe Thr Pro Gln Phe Ile Asp Gln Gln
        515                 520                 525             
Gln Phe Tyr Leu Ala Leu Asp Asn Lys Met Ile Val Glu Met Leu Arg
    530                 535                 540                 
Thr Asp Leu Ser Tyr Leu Cys Ser Arg Trp Arg Met Thr Gly Gln Pro
545                 550                 555                 560 
Thr Ile Thr Phe Pro Ile Ser Tyr Ser Met Leu Asp Glu Asp Gly Thr
                565                 570                 575     
Ser Leu Asn Ser Ser Ile Leu Ala Ala Leu Arg Lys Met Gln Asp Gly
            580                 585                 590         
Tyr Phe Gly Gly Ala Arg Val Gln Thr Gly Lys Leu Ser Glu Phe Leu
        595                 600                 605             
Thr Thr Ser Cys Cys Thr His Leu Ser Phe Met Asp Pro Gly Pro Glu
    610                 615                 620                 
Gly Lys Leu Tyr Ser Glu Asp Tyr Asp Asp Asn Tyr Asp Tyr Leu Glu
625                 630                 635                 640 
Ser Gly Asn Trp Met Asn Asp Tyr Asp Ser Thr Ser His Ala Arg Cys
                645                 650                 655     
Gly Asp Glu Val Ala Arg Tyr Leu Asp His Leu Leu Ala His Thr Ala
            660                 665                 670         
Pro His Pro Lys Leu Ala Pro Thr Ser Gln Lys Gly Gly Leu Asp Arg
        675                 680                 685             
Phe Gln Ala Ala Val Gln Thr Thr Cys Asp Leu Met Ser Leu Val Thr
    690                 695                 700                 
Lys Ala Lys Glu Leu His Val Gln Asn Val His Met Tyr Leu Pro Thr
705                 710                 715                 720 
Lys Leu Phe Gln Ala Ser Arg Pro Ser Phe Asn Leu Leu Asp Ser Pro
                725                 730                 735     
His Pro Arg Gln Glu Asn Gln Val Pro Ser Val Arg Val Glu Ile His
            740                 745                 750         
Leu Pro Arg Asp Gln Ser Gly Glu Val Asp Phe Lys Ala Leu Val Leu
        755                 760                 765             
Gln Leu Lys Glu Thr Ser Ser Leu Gln Glu Gln Ala Asp Ile Leu Tyr
    770                 775                 780                 
Met Leu Tyr Thr Met Lys Gly Pro Asp Trp Asn Thr Glu Leu Tyr Asn
785                 790                 795                 800 
Glu Arg Ser Ala Thr Val Arg Glu Leu Leu Thr Glu Leu Tyr Gly Lys
                805                 810                 815     
Val Gly Glu Ile Arg His Trp Gly Leu Ile Arg Tyr Ile Ser Gly Ile
            820                 825                 830         
Leu Arg Lys Lys Val Glu Ala Leu Asp Glu Ala Cys Thr Asp Leu Leu
        835                 840                 845             
Ser His Gln Lys His Leu Thr Val Gly Leu Pro Pro Glu Pro Arg Glu
    850                 855                 860                 
Lys Thr Ile Ser Ala Pro Leu Pro Tyr Glu Ala Leu Thr Gln Leu Ile
865                 870                 875                 880 
Asp Glu Ala Ser Glu Gly Asp Met Ser Ile Ser Ile Leu Thr Gln Glu
                885                 890                 895     
Ile Met Val Tyr Leu Ala Met Tyr Met Arg Thr Gln Pro Gly Leu Phe
            900                 905                 910         
Ala Glu Met Phe Arg Leu Arg Ile Gly Leu Ile Ile Gln Val Met Ala
        915                 920                 925             
Thr Glu Leu Ala His Ser Leu Arg Cys Ser Ala Glu Glu Ala Thr Glu
    930                 935                 940                 
Gly Leu Met Asn Leu Ser Pro Ser Ala Met Lys Asn Leu Leu His His
945                 950                 955                 960 
Ile Leu Ser Gly Lys Glu Phe Gly Val Glu Arg Ser Val Arg Pro Thr
                965                 970                 975     
Asp Ser Asn Val Ser Pro Ala Ile Ser Ile His Glu Ile Gly Ala Val
            980                 985                 990         
Gly Ala Thr Lys Thr Glu Arg Thr Gly Ile Met Gln Leu Lys Ser Glu
        995                 1000                1005            
Ile Lys Gln Val Glu Phe Arg Arg Leu Ser Ile Ser Ala Glu Ser Gln
    1010                1015                1020                
Ser Pro Gly Thr Ser Met Thr Pro Ser Ser Gly Ser Phe Pro Ser Ala
1025                1030                1035                1040
Tyr Asp Gln Gln Ser Ser Lys Asp Ser Arg Gln Gly Gln Trp Gln Arg
                1045                1050                1055    
Arg Arg Arg Leu Asp Gly Ala Leu Asn Arg Val Pro Val Gly Phe Tyr
            1060                1065                1070        
Gln Lys Val Trp Lys Val Leu Gln Lys Cys His Gly Leu Ser Val Glu
        1075                1080                1085            
Gly Phe Val Leu Pro Ser Ser Thr Thr Arg Glu Met Thr Pro Gly Glu
    1090                1095                1100                
Ile Lys Phe Ser Val His Val Glu Ser Val Leu Asn Arg Val Pro Gln
1105                1110                1115                1120
Pro Glu Tyr Arg Gln Leu Leu Val Glu Ala Ile Leu Val Leu Thr Met
                1125                1130                1135    
Leu Ala Asp Ile Glu Ile His Ser Ile Gly Ser Ile Ile Ala Val Glu
            1140                1145                1150        
Lys Ile Val His Ile Ala Asn Asp Leu Phe Leu Gln Glu Gln Lys Thr
        1155                1160                1165            
Leu Gly Ala Asp Asp Thr Met Leu Ala Lys Asp Pro Ala Ser Gly Ile
    1170                1175                1180                
Cys Thr Leu Leu Tyr Asp Ser Ala Pro Ser Gly Arg Phe Gly Thr Met
1185                1190                1195                1200
Thr Tyr Leu Ser Lys Ala Ala Ala Thr Tyr Val Gln Glu Phe Leu Pro
                1205                1210                1215    
His Ser Ile Cys Ala Met Gln
            1220            


<210> 7635
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 7635
Met Arg Ser Arg Ser Asn Ser Gly Val Arg Leu Asp Gly Tyr Ala Arg
 1               5                  10                  15      
Leu Val Gln Gln Thr Ile Leu Cys His Gln Asn Pro Val Thr Gly Leu
            20                  25                  30          
Leu Pro Ala Ser Tyr Asp Gln Lys Asp Ala Trp Val Arg Asp Asn Val
        35                  40                  45              
Tyr Ser Ile Leu Ala Val Trp Gly Leu Gly Leu Ala Tyr Arg Lys Asn
    50                  55                  60                  
Ala Asp Arg Asp Glu Asp Lys Ala Lys Ala Tyr Glu Leu Glu Gln Ser
65                  70                  75                  80  
Val Val Lys Leu Met Arg Gly Leu Leu His Cys Met Ile Arg Gln Val
                85                  90                  95      
Asp Lys Val Glu Ser Phe Lys Tyr Ser Gln Ser Thr Lys Asp Ser Leu
            100                 105                 110         
His Ala Lys Tyr Asn Thr Lys Thr Cys Ala Thr Val Val Gly Asp Asp
        115                 120                 125             
Gln Trp Gly His Leu Gln Leu Asp Ala Thr Ser Val Tyr Leu Leu Phe
    130                 135                 140                 
Leu Ala Gln Met Thr Ala Ser Gly Leu His Ile Ile His Ser Leu Asp
145                 150                 155                 160 
Glu Val Asn Phe Ile Gln Asn Leu Val Phe Tyr Ile Glu Ala Ala Tyr
                165                 170                 175     
Lys Thr Ala Asp Phe Gly Ile Trp Glu Arg Gly Asp Lys Thr Asn Gln
            180                 185                 190         
Gly Ile Ser Glu Leu Asn Ala Ser Ser Val Gly Met Ala Lys Ala Ala
        195                 200                 205             
Leu Glu Ala Leu Asp Glu Leu Asp Leu Phe Gly Val Lys Gly Gly Pro
    210                 215                 220                 
Gln Ser Val Ile His Val Leu Ala Asp Glu Val Gln His Cys Gln Ser
225                 230                 235                 240 
Ile Leu Asn Ser Leu Leu Pro Arg Ala Ser Thr Ser Lys Glu Val Asp
                245                 250                 255     
Ala Ser Leu Leu Ser Val Val Ser Phe Pro Ala Phe Ala Val Glu Asp
            260                 265                 270         
Ser Gln Leu Val Glu Leu Thr Lys Gln Glu Ile Ile Thr Lys Leu Gln
        275                 280                 285             
Gly Arg Tyr Gly Cys Cys Arg Phe Leu Arg Asp Gly Tyr Lys Thr Pro
    290                 295                 300                 
Lys Glu Asp Pro Asn Arg Leu Tyr Tyr Glu Pro Ala Glu Leu Lys Leu
305                 310                 315                 320 
Phe Glu Asn Ile Glu Cys Glu Trp Pro Leu Phe Trp Thr Tyr Phe Ile
                325                 330                 335     
Leu Asp Gly Val Phe Ser Gly Asn Ala Glu Gln Val Gln Glu Tyr Lys
            340                 345                 350         
Glu Ala Leu Glu Ala Val Leu Ile Lys Gly Lys Asn Gly Val Pro Leu
        355                 360                 365             
Leu Pro Glu Leu Tyr Ser Val Pro Pro Asp Arg Val Asp Glu Glu Tyr
    370                 375                 380                 
Gln Asn Pro His Thr Val Asp Arg Val Pro Met Gly Lys Leu Pro His
385                 390                 395                 400 
Met Trp Gly Gln Ser Leu Tyr Ile Leu Gly Ser Leu Met Ala Glu Gly
                405                 410                 415     
Phe Leu Ala Pro Gly Glu Ile Asp Pro Leu Asn Arg Arg Phe Ser Thr
            420                 425                 430         
Val Pro Lys Pro Asp Val Val Val Gln Val Ser Ile Leu Ala Glu Thr
        435                 440                 445             
Glu Glu Ile Lys Thr Ile Leu Lys Asp Lys Gly Ile Tyr Val Glu Thr
    450                 455                 460                 
Ile Ala Glu Val Tyr Pro Ile Arg Val Gln Pro Ala Arg Ile Leu Ser
465                 470                 475                 480 
His Ile Tyr Ser Ser Leu Gly Cys Asn Asn Arg Met Lys Leu Ser Gly
                485                 490                 495     
Arg Pro Tyr Arg His Met Gly Val Leu Gly Thr Ser Lys Leu Tyr Asp
            500                 505                 510         
Ile Arg Lys Thr Ile Phe Thr Phe Thr Pro Gln Phe Ile Asp Gln Gln
        515                 520                 525             
Gln Phe Tyr Leu Ala Leu Asp Asn Lys Met Ile Val Glu Met Leu Arg
    530                 535                 540                 
Thr Asp Leu Ser Tyr Leu Cys Ser Arg Trp Arg Met Thr Gly Gln Pro
545                 550                 555                 560 
Thr Ile Thr Phe Pro Ile Ser Tyr Ser Met Leu Asp Glu Asp Gly Thr
                565                 570                 575     
Ser Leu Asn Ser Ser Ile Leu Ala Ala Leu Arg Lys Met Gln Asp Gly
            580                 585                 590         
Tyr Phe Gly Gly Ala Arg Val Gln Thr Gly Lys Leu Ser Glu Phe Leu
        595                 600                 605             
Thr Thr Ser Cys Cys Thr His Leu Ser Phe Met Asp Pro Gly Pro Glu
    610                 615                 620                 
Gly Lys Leu Tyr Ser Glu Asp Tyr Asp Asp Asn Tyr Asp Tyr Leu Glu
625                 630                 635                 640 
Ser Gly Asn Trp Met Asn Asp Tyr Asp Ser Thr Ser His Ala Arg Cys
                645                 650                 655     
Gly Asp Glu Val Ala Arg Tyr Leu Asp His Leu Leu Ala His Thr Ala
            660                 665                 670         
Pro His Pro Lys Leu Ala Pro Thr Ser Gln Lys Gly Gly Leu Asp Arg
        675                 680                 685             
Phe Gln Ala Ala Val Gln Thr Thr Cys Asp Leu Met Ser Leu Val Thr
    690                 695                 700                 
Lys Ala Lys Glu Leu His Val Gln Asn Val His Met Tyr Leu Pro Thr
705                 710                 715                 720 
Lys Leu Phe Gln Ala Ser Arg Pro Ser Phe Asn Leu Leu Asp Ser Pro
                725                 730                 735     
His Pro Arg Gln Glu Asn Gln Val Pro Ser Val Arg Val Glu Ile His
            740                 745                 750         
Leu Pro Arg Asp Gln Ser Gly Glu Val Asp Phe Lys Ala Leu Val Leu
        755                 760                 765             
Gln Leu Lys Glu Thr Ser Ser Leu Gln Glu Gln Ala Asp Ile Leu Tyr
    770                 775                 780                 
Met Leu Tyr Thr Met Lys Gly Pro Asp Trp Asn Thr Glu Leu Tyr Asn
785                 790                 795                 800 
Glu Arg Ser Ala Thr Val Arg Glu Leu Leu Thr Glu Leu Tyr Gly Lys
                805                 810                 815     
Val Gly Glu Ile Arg His Trp Gly Leu Ile Arg Tyr Ile Ser Gly Ile
            820                 825                 830         
Leu Arg Lys Lys Val Glu Ala Leu Asp Glu Ala Cys Thr Asp Leu Leu
        835                 840                 845             
Ser His Gln Lys His Leu Thr Val Gly Leu Pro Pro Glu Pro Arg Glu
    850                 855                 860                 
Lys Thr Ile Ser Ala Pro Leu Pro Tyr Glu Ala Leu Thr Gln Leu Ile
865                 870                 875                 880 
Asp Glu Ala Ser Glu Gly Asp Met Ser Ile Ser Ile Leu Thr Gln Glu
                885                 890                 895     
Ile Met Val Tyr Leu Ala Met Tyr Met Arg Thr Gln Pro Gly Leu Phe
            900                 905                 910         
Ala Glu Met Phe Arg Leu Arg Ile Gly Leu Ile Ile Gln Val Met Ala
        915                 920                 925             
Thr Glu Leu Ala His Ser Leu Arg Cys Ser Ala Glu Glu Ala Thr Glu
    930                 935                 940                 
Gly Leu Met Asn Leu Ser Pro Ser Ala Met Lys Asn Leu Leu His His
945                 950                 955                 960 
Ile Leu Ser Gly Lys Glu Phe Gly Val Glu Arg Ser Val Arg Pro Thr
                965                 970                 975     
Asp Ser Asn Val Ser Pro Ala Ile Ser Ile His Glu Ile Gly Ala Val
            980                 985                 990         
Gly Ala Thr Lys Thr Glu Arg Thr Gly Ile Met Gln Leu Lys Ser Glu
        995                 1000                1005            
Ile Lys Gln Ser Pro Gly Thr Ser Met Thr Pro Ser Ser Gly Ser Phe
    1010                1015                1020                
Pro Ser Ala Tyr Asp Gln Gln Ser Ser Lys Asp Ser Arg Gln Gly Gln
1025                1030                1035                1040
Trp Gln Arg Arg Arg Arg Leu Asp Gly Ala Leu Asn Arg Val Pro Val
                1045                1050                1055    
Gly Phe Tyr Gln Lys Val Trp Lys Val Leu Gln Lys Cys His Gly Leu
            1060                1065                1070        
Ser Val Glu Gly Phe Val Leu Pro Ser Ser Thr Thr Arg Glu Met Thr
        1075                1080                1085            
Pro Gly Glu Ile Lys Phe Ser Val His Val Glu Ser Val Leu Asn Arg
    1090                1095                1100                
Val Pro Gln Pro Glu Tyr Arg Gln Leu Leu Val Glu Ala Ile Leu Val
1105                1110                1115                1120
Leu Thr Met Leu Ala Asp Ile Glu Ile His Ser Ile Gly Ser Ile Ile
                1125                1130                1135    
Ala Val Glu Lys Ile Val His Ile Ala Asn Asp Leu Phe Leu Gln Glu
            1140                1145                1150        
Gln Lys Thr Leu Gly Ala Asp Asp Thr Met Leu Ala Lys Asp Pro Ala
        1155                1160                1165            
Ser Gly Ile Cys Thr Leu Leu Tyr Asp Ser Ala Pro Ser Gly Arg Phe
    1170                1175                1180                
Gly Thr Met Thr Tyr Leu Ser Lys Ala Ala Ala Thr Tyr Val Gln Glu
1185                1190                1195                1200
Phe Leu Pro His Ser Ile Cys Ala Met Gln
                1205                1210


<210> 7636
<211> 497
<212> PRT
<213> Homo sapiens

<400> 7636
Ala Arg Ala Gly Arg Gly Ala Ala Ser Gly Pro Pro Arg Val Ala Gln
 1               5                  10                  15      
Thr Ser Asp Pro Asp Ser Ser Glu Ala Cys Ala Glu Glu Glu Glu Gly
            20                  25                  30          
Leu Met Pro Gln Gly Pro Gln Leu Leu Asp Phe Ser Val Asp Glu Val
        35                  40                  45              
Ala Glu Gln Leu Thr Leu Ile Asp Leu Glu Leu Phe Ser Lys Val Arg
    50                  55                  60                  
Leu Tyr Glu Cys Leu Gly Ser Val Trp Ser Gln Arg Asp Arg Pro Gly
65                  70                  75                  80  
Ala Ala Gly Ala Ser Pro Thr Val Arg Ala Thr Val Ala Gln Phe Asn
                85                  90                  95      
Thr Val Thr Gly Cys Val Leu Gly Ser Val Leu Gly Ala Pro Gly Leu
            100                 105                 110         
Ala Ala Pro Gln Arg Ala Gln Arg Leu Glu Lys Trp Ile Arg Ile Ala
        115                 120                 125             
Gln Arg Cys Arg Glu Leu Arg Asn Phe Ser Ser Leu Arg Ala Ile Leu
    130                 135                 140                 
Ser Ala Leu Gln Ser Asn Pro Ile Tyr Arg Leu Lys Arg Ser Trp Gly
145                 150                 155                 160 
Ala Val Ser Arg Glu Pro Leu Ser Thr Phe Arg Lys Leu Ser Gln Ile
                165                 170                 175     
Phe Ser Asp Glu Asn Asn His Leu Ser Ser Arg Glu Ile Leu Phe Gln
            180                 185                 190         
Glu Glu Ala Thr Glu Gly Ser Gln Glu Glu Asp Asn Thr Pro Gly Ser
        195                 200                 205             
Leu Pro Ser Lys Pro Pro Pro Gly Pro Val Pro Tyr Leu Gly Thr Phe
    210                 215                 220                 
Leu Thr Asp Leu Val Met Leu Asp Thr Ala Leu Pro Asp Met Leu Glu
225                 230                 235                 240 
Gly Asp Leu Ile Asn Phe Glu Lys Arg Arg Lys Glu Trp Glu Ile Leu
                245                 250                 255     
Ala Arg Ile Gln Gln Leu Gln Arg Arg Cys Gln Ser Tyr Thr Leu Ser
            260                 265                 270         
Pro His Pro Pro Ile Leu Ala Ala Leu His Ala Gln Asn Gln Leu Thr
        275                 280                 285             
Glu Glu Gln Ser Tyr Arg Leu Ser Arg Val Ile Glu Pro Pro Ala Ala
    290                 295                 300                 
Ser Cys Pro Ser Ser Pro Arg Ile Arg Arg Arg Ile Ser Leu Thr Lys
305                 310                 315                 320 
Arg Leu Ser Ala Lys Leu Ala Arg Glu Lys Ser Ser Ser Pro Ser Gly
                325                 330                 335     
Ser Pro Gly Asp Pro Ser Ser Pro Thr Ser Ser Val Ser Pro Gly Ser
            340                 345                 350         
Pro Pro Ser Ser Pro Arg Ser Arg Asp Ala Pro Ala Gly Ser Pro Pro
        355                 360                 365             
Ala Ser Pro Gly Pro Gln Gly Pro Ser Thr Lys Leu Pro Leu Ser Leu
    370                 375                 380                 
Asp Leu Pro Ser Pro Arg Pro Phe Ala Leu Pro Leu Gly Ser Pro Arg
385                 390                 395                 400 
Ile Pro Leu Pro Ala Gln Gln Ser Ser Glu Ala Cys Val Ile Arg Val
                405                 410                 415     
Ser Ile Asp Asn Asp His Gly Asn Leu Tyr Arg Ser Ile Leu Leu Thr
            420                 425                 430         
Ser Gln Asp Lys Ala Pro Ser Val Val Arg Arg Ala Leu Gln Lys His
        435                 440                 445             
Asn Val Pro Gln Pro Trp Ala Cys Asp Tyr Gln Leu Phe Gln Val Leu
    450                 455                 460                 
Pro Gly Asp Arg Gly Trp Glu Glu Met Leu Ile Ser Ala Ile Lys Ser
465                 470                 475                 480 
Val Gly Thr Phe Phe Gly Met Phe Ala Met Cys Gln Ala Arg Phe Tyr
                485                 490                 495     
Arg
    


<210> 7637
<211> 605
<212> PRT
<213> Homo sapiens

<400> 7637
Met Ala Ala Gly Gln Arg Glu Ala Arg Pro Gln Val Ser Leu Thr Phe
 1               5                  10                  15      
Glu Asp Val Ala Val Leu Phe Thr Arg Asp Glu Trp Arg Lys Leu Ala
            20                  25                  30          
Pro Ser Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg
        35                  40                  45              
Asn Leu Val Ser Leu Gly Leu Pro Phe Thr Lys Pro Lys Val Ile Ser
    50                  55                  60                  
Leu Leu Gln Gln Gly Glu Asp Pro Trp Glu Val Glu Lys Asp Gly Ser
65                  70                  75                  80  
Gly Val Ser Ser Leu Gly Ser Lys Ser Ser His Lys Thr Thr Lys Ser
                85                  90                  95      
Thr Gln Thr Gln Asp Ser Ser Phe Gln Gly Leu Ile Leu Lys Arg Ser
            100                 105                 110         
Asn Arg Asn Val Pro Trp Asp Leu Lys Leu Glu Lys Pro Tyr Ile Tyr
        115                 120                 125             
Glu Gly Arg Leu Glu Lys Lys Gln Asp Lys Lys Gly Ser Phe Gln Ile
    130                 135                 140                 
Val Ser Ala Thr His Lys Lys Ile Pro Thr Ile Glu Arg Ser His Lys
145                 150                 155                 160 
Asn Thr Glu Leu Ser Gln Asn Phe Ser Pro Lys Ser Val Leu Ile Arg
                165                 170                 175     
Gln Gln Ile Leu Pro Arg Glu Lys Thr Pro Pro Lys Cys Glu Ile Gln
            180                 185                 190         
Gly Asn Ser Leu Lys Gln Asn Ser Gln Leu Leu Asn Gln Pro Lys Ile
        195                 200                 205             
Thr Ala Asp Lys Arg Tyr Lys Cys Ser Leu Cys Glu Lys Thr Phe Ile
    210                 215                 220                 
Asn Thr Ser Ser Leu Arg Lys His Glu Lys Asn His Ser Gly Glu Lys
225                 230                 235                 240 
Leu Phe Lys Cys Lys Glu Cys Ser Lys Ala Phe Ser Gln Ser Ser Ala
                245                 250                 255     
Leu Ile Gln His Gln Ile Thr His Thr Gly Glu Lys Pro Tyr Ile Cys
            260                 265                 270         
Lys Glu Cys Gly Lys Ala Phe Thr Leu Ser Thr Ser Leu Tyr Lys His
        275                 280                 285             
Leu Arg Thr His Thr Val Glu Lys Ser Tyr Arg Cys Lys Glu Cys Gly
    290                 295                 300                 
Lys Ser Phe Ser Arg Arg Ser Gly Leu Phe Ile His Gln Lys Ile His
305                 310                 315                 320 
Ala Glu Glu Asn Pro Cys Lys Tyr Asn Pro Gly Arg Lys Ala Ser Ser
                325                 330                 335     
Cys Ser Thr Ser Leu Ser Gly Cys Gln Arg Ile His Ser Arg Lys Lys
            340                 345                 350         
Ser Tyr Leu Cys Asn Glu Cys Gly Asn Thr Phe Lys Ser Ser Ser Ser
        355                 360                 365             
Leu Arg Tyr His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys
    370                 375                 380                 
Ser Glu Cys Gly Arg Ala Phe Ser Gln Ser Ala Ser Leu Ile Gln His
385                 390                 395                 400 
Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Asn Glu Cys Gly
                405                 410                 415     
Lys Gly Phe Thr Ser Ile Ser Arg Leu Asn Arg His Arg Ile Ile His
            420                 425                 430         
Thr Gly Glu Lys Tyr Tyr Asn Cys Asn Glu Cys Gly Lys Ala Leu Ser
        435                 440                 445             
Ser His Ser Thr Leu Ile Ile His Glu Arg Ile His Thr Gly Glu Lys
    450                 455                 460                 
Pro Cys Lys Cys Lys Val Cys Gly Lys Ala Phe Arg Gln Ser Ser Ala
465                 470                 475                 480 
Leu Ile Gln His Gln Arg Met His Thr Gly Glu Arg Pro Tyr Lys Cys
                485                 490                 495     
Asn Glu Cys Gly Lys Thr Phe Arg Cys Asn Ser Ser Leu Ser Asn His
            500                 505                 510         
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Glu Glu Cys Gly
        515                 520                 525             
Ile Ser Phe Gly Gln Ser Ser Ala Leu Ile Gln His Arg Arg Ile His
    530                 535                 540                 
Thr Gly Glu Lys Pro Phe Lys Cys Asn Thr Cys Gly Lys Thr Phe Arg
545                 550                 555                 560 
Gln Ser Ser Ser Arg Ile Ala His Gln Arg Ile His Thr Gly Glu Lys
                565                 570                 575     
Pro Tyr Glu Cys Asn Thr Cys Gly Lys Leu Phe Asn His Arg Ser Ser
            580                 585                 590         
Leu Thr Asn His Tyr Lys Ile His Ile Glu Glu Asp Pro
        595                 600                 605 


<210> 7638
<211> 612
<212> PRT
<213> Homo sapiens

<400> 7638
Met Ala Ala Gly Gln Arg Glu Ala Arg Pro Gln Val Ser Leu Thr Phe
 1               5                  10                  15      
Glu Asp Val Ala Val Leu Phe Thr Trp Asp Glu Trp Arg Lys Leu Ala
            20                  25                  30          
Pro Ser Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg
        35                  40                  45              
Asn Leu Val Ser Leu Gly Leu Ser Phe Thr Lys Pro Lys Val Ile Ser
    50                  55                  60                  
Leu Leu Gln Gln Gly Glu Asp Pro Trp Glu Val Glu Lys Asp Ser Ser
65                  70                  75                  80  
Gly Val Ser Ser Leu Gly Cys Lys Ser Thr Pro Lys Met Thr Lys Ser
                85                  90                  95      
Thr Gln Thr Gln Asp Ser Phe Gln Glu Gln Ile Arg Lys Arg Leu Lys
            100                 105                 110         
Arg Asp Glu Pro Trp Asn Phe Ile Ser Glu Arg Ser Cys Ile Tyr Glu
        115                 120                 125             
Glu Lys Leu Lys Lys Gln Gln Asp Lys Asn Glu Asn Leu Gln Ile Ile
    130                 135                 140                 
Ser Val Ala His Thr Lys Ile Leu Thr Val Asp Arg Ser His Lys Asn
145                 150                 155                 160 
Val Glu Phe Gly Gln Asn Phe Tyr Leu Lys Ser Val Phe Ile Lys Gln
                165                 170                 175     
Gln Arg Phe Ala Lys Glu Lys Thr Pro Ser Lys Cys Glu Ile Gln Arg
            180                 185                 190         
Asn Ser Phe Lys Gln Asn Ser Asn Leu Leu Asn Gln Ser Lys Ile Lys
        195                 200                 205             
Thr Ala Glu Lys Arg Tyr Lys Cys Ser Thr Cys Glu Lys Ala Phe Ile
    210                 215                 220                 
His Asn Ser Ser Leu Arg Lys His Gln Lys Asn His Thr Gly Glu Lys
225                 230                 235                 240 
Leu Phe Lys Cys Lys Glu Cys Leu Lys Ala Phe Ser Gln Ser Ser Ala
                245                 250                 255     
Leu Ile Gln His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Ile Cys
            260                 265                 270         
Lys Glu Cys Gly Lys Ala Phe Ser His Ser Ala Ser Leu Cys Lys His
        275                 280                 285             
Leu Arg Thr His Thr Val Glu Lys Cys Tyr Arg Cys Lys Glu Cys Gly
    290                 295                 300                 
Lys Ser Phe Ser Arg Arg Ser Gly Leu Phe Ile His Gln Lys Ile His
305                 310                 315                 320 
Ala Gln Glu Asn Pro His Lys Tyr Asn Pro Gly Arg Lys Ala Ser Ser
                325                 330                 335     
Tyr Ser Thr Ser Leu Ser Gly Ser Gln Lys Ile His Leu Arg Lys Lys
            340                 345                 350         
Ser Tyr Leu Cys Asn Glu Cys Gly Asn Thr Phe Lys Ser Ser Ser Ser
        355                 360                 365             
Leu Arg Tyr His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys
    370                 375                 380                 
Ser Glu Cys Gly Arg Ala Phe Ser Gln Ser Ala Ser Leu Ile Gln His
385                 390                 395                 400 
Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Asn Glu Cys Gly
                405                 410                 415     
Lys Gly Phe Thr Ser Ile Ser Arg Leu Asn Arg His Arg Ile Ile His
            420                 425                 430         
Thr Gly Glu Lys Leu Tyr Asn Cys Asn Glu Cys Gly Lys Ala Leu Ser
        435                 440                 445             
Ser His Ser Thr Leu Ile Ile His Glu Arg Ile His Thr Gly Glu Lys
    450                 455                 460                 
Pro Cys Lys Cys Lys Val Cys Gly Lys Ala Phe Arg Gln Ser Ser Ala
465                 470                 475                 480 
Leu Ile Gln His Gln Arg Met His Thr Gly Glu Arg Pro Tyr Lys Cys
                485                 490                 495     
Asn Glu Cys Asp Lys Thr Phe Arg Cys Asn Ser Ser Leu Ser Asn His
            500                 505                 510         
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Leu Glu Cys Gly
        515                 520                 525             
Met Ser Phe Gly Gln Ser Ala Ala Leu Ile Gln His Gln Arg Ile His
    530                 535                 540                 
Thr Gly Glu Lys Pro Phe Lys Cys Asn Thr Cys Gly Lys Thr Phe Arg
545                 550                 555                 560 
Gln Ser Ser Ser Leu Ile Ala His Gln Arg Ile His Thr Gly Glu Lys
                565                 570                 575     
Pro Tyr Glu Cys Asn Ala Cys Gly Lys Leu Phe Ser Gln Arg Ser Ser
            580                 585                 590         
Leu Thr Asn His Tyr Lys Ile His Ile Glu Glu Asp Ser Leu Lys Ala
        595                 600                 605             
Asp Leu His Val
    610         


<210> 7639
<211> 2303
<212> PRT
<213> Homo sapiens

<400> 7639
Met Thr Ser Glu Glu Met Thr Ala Ser Val Leu Ile Pro Val Thr Gln
 1               5                  10                  15      
Arg Lys Val Val Ser Ala Gln Ser Ala Ala Asp Glu Ser Ser Glu Lys
            20                  25                  30          
Val Ser Asp Ile Asn Ile Ser Lys Ala His Thr Val Arg Arg Ser Gly
        35                  40                  45              
Glu Thr Ser His Thr Ile Ser Gln Leu Asn Lys Leu Lys Glu Glu Pro
    50                  55                  60                  
Ser Gly Ser Asn Leu Pro Lys Ile Leu Ser Ile Ala Arg Glu Lys Ile
65                  70                  75                  80  
Val Ser Asp Glu Asn Ser Asn Glu Lys Cys Trp Glu Lys Ile Met Pro
                85                  90                  95      
Asp Ser Ala Lys Asn Leu Asn Ile Asn Cys Asn Asn Ile Leu Arg Asn
            100                 105                 110         
His Gln His Gly Leu Pro Gln Arg Gln Phe Tyr Glu Met Tyr Asn Ser
        115                 120                 125             
Val Ala Glu Glu Asp Leu Cys Leu Glu Thr Gly Ile Pro Ser Pro Leu
    130                 135                 140                 
Glu Arg Lys Val Phe Pro Gly Ile Gln Leu Glu Leu Asp Arg Pro Ser
145                 150                 155                 160 
Met Gly Ile Ser Pro Leu Gly Asn Gln Ser Val Ile Ile Glu Thr Gly
                165                 170                 175     
Arg Ala His Pro Asp Ser Arg Arg Ala Val Phe His Phe His Tyr Glu
            180                 185                 190         
Val Asp Arg Arg Met Ser Asp Thr Phe Cys Thr Leu Ser Glu Asn Leu
        195                 200                 205             
Ile Leu Asp Asp Cys Gly Asn Cys Val Pro Leu Pro Gly Gly Glu Glu
    210                 215                 220                 
Lys Gln Lys Lys Asn Tyr Val Ala Tyr Thr Cys Lys Leu Met Glu Leu
225                 230                 235                 240 
Ala Lys Asn Cys Asp Asn Lys Asn Glu Gln Leu Gln Cys Asp His Cys
                245                 250                 255     
Asp Thr Leu Asn Asp Lys Tyr Phe Cys Phe Glu Gly Ser Cys Glu Lys
            260                 265                 270         
Val Asp Met Val Tyr Ser Gly Asp Ser Phe Cys Arg Lys Asp Phe Thr
        275                 280                 285             
Asp Ser Gln Ala Ala Lys Thr Phe Leu Ser His Phe Glu Asp Phe Pro
    290                 295                 300                 
Asp Asn Cys Asp Asp Val Glu Glu Asp Ala Phe Lys Ser Lys Lys Glu
305                 310                 315                 320 
Arg Ser Thr Leu Leu Val Arg Arg Phe Cys Lys Asn Asp Arg Glu Val
                325                 330                 335     
Lys Lys Ser Val Tyr Thr Gly Thr Arg Ala Ile Val Arg Thr Leu Pro
            340                 345                 350         
Ser Gly His Ile Gly Leu Thr Ala Trp Ser Tyr Ile Asp Gln Lys Arg
        355                 360                 365             
Asn Gly Pro Leu Leu Pro Cys Gly Arg Val Met Glu Pro Pro Ser Thr
    370                 375                 380                 
Val Glu Ile Arg Gln Asp Gly Ser Gln Arg Leu Ser Glu Ala Gln Trp
385                 390                 395                 400 
Tyr Pro Ile Tyr Asn Ala Val Arg Arg Glu Glu Thr Glu Asn Thr Val
                405                 410                 415     
Gly Ser Leu Leu His Phe Leu Thr Lys Leu Pro Ala Ser Glu Thr Ala
            420                 425                 430         
His Gly Arg Ile Ser Val Gly Pro Cys Leu Lys Gln Cys Val Arg Asp
        435                 440                 445             
Thr Val Cys Glu Tyr Arg Ala Thr Leu Gln Arg Thr Ser Ile Ser Gln
    450                 455                 460                 
Tyr Ile Thr Gly Ser Leu Leu Glu Ala Thr Thr Ser Leu Gly Ala Arg
465                 470                 475                 480 
Ser Gly Leu Leu Ser Thr Phe Gly Gly Ser Thr Gly Arg Met Met Leu
                485                 490                 495     
Lys Glu Arg Gln Pro Gly Pro Ser Val Ala Asn Ser Asn Ala Leu Pro
            500                 505                 510         
Ser Ser Ser Ala Gly Ile Ser Lys Glu Leu Ile Asp Leu Gln Pro Leu
        515                 520                 525             
Ile Gln Phe Pro Glu Glu Val Ala Ser Ile Leu Met Glu Gln Glu Gln
    530                 535                 540                 
Thr Ile Tyr Arg Arg Val Leu Pro Val Asp Tyr Leu Cys Phe Leu Thr
545                 550                 555                 560 
Arg Asp Leu Gly Thr Pro Glu Cys Gln Ser Ser Leu Pro Cys Leu Lys
                565                 570                 575     
Ala Ser Ile Ser Ala Ser Ile Leu Thr Thr Gln Asn Gly Glu His Asn
            580                 585                 590         
Ala Leu Glu Asp Leu Val Met Arg Phe Asn Glu Val Ser Ser Trp Val
        595                 600                 605             
Thr Trp Leu Ile Leu Thr Ala Gly Ser Met Glu Glu Lys Arg Glu Val
    610                 615                 620                 
Phe Ser Tyr Leu Val His Val Ala Lys Cys Cys Trp Asn Met Gly Asn
625                 630                 635                 640 
Tyr Asn Ala Val Met Glu Phe Leu Ala Gly Leu Arg Ser Arg Lys Val
                645                 650                 655     
Leu Lys Met Trp Gln Phe Met Asp Gln Ser Asp Ile Glu Thr Met Arg
            660                 665                 670         
Ser Leu Lys Asp Ala Met Ala Gln His Glu Ser Ser Cys Glu Tyr Arg
        675                 680                 685             
Lys Val Val Thr Arg Ala Leu His Ile Pro Gly Cys Lys Val Val Pro
    690                 695                 700                 
Phe Cys Gly Val Phe Leu Lys Glu Leu Cys Glu Val Leu Asp Gly Ala
705                 710                 715                 720 
Ser Gly Leu Met Lys Leu Cys Pro Arg Tyr Asn Ser Gln Glu Glu Thr
                725                 730                 735     
Leu Glu Phe Val Ala Asp Tyr Ser Gly Gln Asp Asn Phe Leu Gln Arg
            740                 745                 750         
Val Gly Gln Asn Gly Leu Lys Asn Ser Glu Lys Glu Ser Thr Val Asn
        755                 760                 765             
Ser Ile Phe Gln Val Ile Arg Ser Cys Asn Arg Ser Leu Glu Thr Asp
    770                 775                 780                 
Glu Glu Asp Ser Pro Ser Glu Gly Asn Ser Ser Arg Lys Ser Ser Leu
785                 790                 795                 800 
Lys Asp Lys Ser Arg Trp Gln Phe Ile Ile Gly Asp Leu Leu Asp Ser
                805                 810                 815     
Asp Asn Asp Ile Phe Glu Gln Ser Lys Glu Tyr Asp Ser His Gly Ser
            820                 825                 830         
Glu Asp Ser Gln Lys Ala Phe Asp His Gly Thr Glu Leu Ile Pro Trp
        835                 840                 845             
Tyr Val Leu Ser Ile Gln Ala Asp Val His Gln Phe Leu Leu Gln Gly
    850                 855                 860                 
Ala Thr Val Ile His Tyr Asp Gln Asp Thr His Leu Ser Ala Arg Cys
865                 870                 875                 880 
Phe Leu Gln Leu Gln Pro Asp Asn Ser Thr Leu Thr Trp Val Lys Pro
                885                 890                 895     
Thr Thr Ala Ser Pro Ala Ser Ser Lys Ala Lys Leu Gly Val Leu Asn
            900                 905                 910         
Asn Thr Ala Glu Pro Gly Lys Phe Pro Leu Leu Gly Asn Ala Gly Leu
        915                 920                 925             
Ser Ser Leu Thr Glu Gly Val Leu Asp Leu Phe Ala Val Lys Ala Val
    930                 935                 940                 
Tyr Met Gly His Pro Gly Ile Asp Ile His Thr Val Cys Val Gln Asn
945                 950                 955                 960 
Lys Leu Gly Ser Met Phe Leu Ser Glu Thr Gly Val Thr Leu Leu Tyr
                965                 970                 975     
Gly Leu Gln Thr Thr Asp Asn Arg Leu Leu His Phe Val Ala Pro Lys
            980                 985                 990         
His Thr Ala Lys Met Leu Phe Ser Gly Leu Leu Glu Leu Thr Arg Ala
        995                 1000                1005            
Val Arg Lys Met Arg Lys Phe Pro Asp Gln Arg Gln Gln Trp Leu Arg
    1010                1015                1020                
Lys Gln Tyr Val Ser Leu Tyr Gln Glu Asp Gly Arg Tyr Glu Gly Pro
1025                1030                1035                1040
Thr Leu Ala His Ala Val Glu Leu Phe Gly Gly Arg Arg Trp Ser Ala
                1045                1050                1055    
Arg Asn Pro Ser Pro Gly Thr Ser Ala Lys Asn Ala Glu Lys Pro Asn
            1060                1065                1070        
Met Gln Arg Asn Asn Thr Leu Gly Ile Ser Thr Thr Lys Lys Lys Lys
        1075                1080                1085            
Lys Ile Leu Met Arg Gly Glu Ser Gly Glu Val Thr Asp Asp Glu Met
    1090                1095                1100                
Ala Thr Arg Lys Ala Lys Met His Lys Glu Cys Arg Ser Arg Ser Gly
1105                1110                1115                1120
Ser Asp Pro Gln Asp Ile Asn Glu Gln Glu Glu Ser Glu Val Asn Ala
                1125                1130                1135    
Ile Ala Asn Pro Pro Asn Pro Leu Pro Ser Arg Arg Ala His Ser Leu
            1140                1145                1150        
Thr Thr Ala Gly Ser Pro Asn Leu Ala Ala Gly Thr Ser Ser Pro Ile
        1155                1160                1165            
Arg Pro Val Ser Ser Pro Val Leu Ser Ser Ser Asn Lys Ser Pro Ser
    1170                1175                1180                
Ser Ala Trp Ser Ser Ser Ser Trp His Gly Arg Ile Lys Gly Gly Met
1185                1190                1195                1200
Lys Gly Phe Gln Ser Phe Met Val Ser Asp Ser Asn Met Ser Phe Val
                1205                1210                1215    
Glu Phe Val Glu Leu Phe Lys Ser Phe Ser Val Arg Ser Arg Lys Asp
            1220                1225                1230        
Leu Lys Asp Leu Phe Asp Val Tyr Ala Val Pro Cys Asn Arg Ser Gly
        1235                1240                1245            
Ser Glu Ser Ala Pro Leu Tyr Thr Asn Leu Thr Ile Asp Glu Asn Thr
    1250                1255                1260                
Ser Asp Leu Gln Pro Asp Leu Asp Leu Leu Thr Arg Asn Val Ser Asp
1265                1270                1275                1280
Leu Gly Leu Phe Ile Lys Ser Lys Gln Gln Leu Ser Asp Asn Gln Arg
                1285                1290                1295    
Gln Ile Ser Asp Ala Ile Ala Ala Ala Ser Ile Val Thr Asn Gly Thr
            1300                1305                1310        
Gly Ile Glu Ser Thr Ser Leu Gly Ile Phe Gly Val Gly Ile Leu Gln
        1315                1320                1325            
Leu Asn Asp Phe Leu Val Asn Cys Gln Gly Glu His Cys Thr Tyr Asp
    1330                1335                1340                
Glu Ile Leu Ser Ile Ile Gln Lys Phe Glu Pro Ser Ile Ser Met Cys
1345                1350                1355                1360
His Gln Gly Leu Met Ser Phe Glu Gly Phe Ala Arg Phe Leu Met Asp
                1365                1370                1375    
Lys Glu Asn Phe Ala Ser Lys Asn Asp Glu Ser Gln Glu Asn Ile Lys
            1380                1385                1390        
Glu Leu Gln Leu Pro Leu Ser Tyr Tyr Tyr Ile Glu Ser Ser His Asn
        1395                1400                1405            
Thr Tyr Leu Thr Gly His Gln Leu Lys Gly Glu Ser Ser Val Glu Leu
    1410                1415                1420                
Tyr Ser Gln Val Leu Leu Gln Gly Cys Arg Ser Val Glu Leu Asp Cys
1425                1430                1435                1440
Trp Asp Gly Asp Asp Gly Met Pro Ile Ile Tyr His Gly His Thr Pro
                1445                1450                1455    
Thr Thr Lys Ile Pro Phe Lys Glu Val Val Glu Ala Ile Asp Arg Ser
            1460                1465                1470        
Ala Phe Ile Asn Ser Asp Leu Pro Ile Ile Ile Ser Ile Glu Asn His
        1475                1480                1485            
Cys Ser Leu Pro Gln Gln Arg Lys Met Ala Glu Ile Phe Lys Thr Val
    1490                1495                1500                
Phe Gly Glu Lys Leu Val Thr Lys Phe Leu Phe Glu Thr Asp Phe Ser
1505                1510                1515                1520
Asp Asp Pro Met Leu Pro Ser Pro Asp Gln Leu Arg Lys Lys Val Leu
                1525                1530                1535    
Leu Lys Asn Lys Lys Leu Lys Ala His Gln Thr Pro Val Asp Ile Leu
            1540                1545                1550        
Lys Gln Lys Ala His Gln Leu Ala Ser Met Gln Val Gln Ala Tyr Asn
        1555                1560                1565            
Gly Gly Asn Ala Asn Pro Arg Pro Ala Asn Asn Glu Glu Glu Glu Asp
    1570                1575                1580                
Glu Glu Asp Glu Tyr Asp Tyr Asp Tyr Glu Ser Leu Ser Asp Asp Asn
1585                1590                1595                1600
Ile Leu Glu Asp Arg Pro Glu Asn Lys Ser Cys Asn Asp Lys Leu Gln
                1605                1610                1615    
Phe Glu Tyr Asn Glu Glu Ile Pro Lys Arg Ile Lys Lys Ala Asp Asn
            1620                1625                1630        
Ser Ala Cys Asn Lys Gly Lys Val Tyr Asp Met Glu Leu Gly Glu Glu
        1635                1640                1645            
Phe Tyr Leu Asp Gln Asn Lys Lys Glu Ser Arg Gln Ile Ala Pro Glu
    1650                1655                1660                
Leu Ser Asp Leu Val Ile Tyr Arg Gln Ala Val Lys Phe Pro Gly Leu
1665                1670                1675                1680
Ser Thr Leu Asn Ala Ser Gly Ser Ser Arg Gly Lys Glu Arg Lys Ser
                1685                1690                1695    
Arg Lys Ser Ile Phe Gly Asn Asn Pro Gly Arg Met Ser Pro Gly Glu
            1700                1705                1710        
Thr Ala Ser Phe Asn Lys Thr Ser Gly Lys Ser Ser Cys Glu Gly Ile
        1715                1720                1725            
Arg Gln Thr Trp Glu Glu Ser Ser Ser Pro Leu Asn Pro Thr Thr Ser
    1730                1735                1740                
Leu Ser Ala Ile Ile Arg Thr Pro Lys Cys Tyr His Ile Ser Ser Leu
1745                1750                1755                1760
Asn Glu Asn Ala Ala Lys Arg Leu Cys Arg Arg Tyr Ser Gln Lys Leu
                1765                1770                1775    
Ile Gln His Thr Ala Cys Gln Leu Leu Arg Thr Tyr Pro Ala Ala Thr
            1780                1785                1790        
Arg Ile Asp Ser Ser Asn Pro Asn Pro Leu Met Phe Trp Leu His Gly
        1795                1800                1805            
Ile Gln Leu Val Ala Leu Asn Tyr Gln Thr Asp Asp Leu Pro Leu His
    1810                1815                1820                
Leu Asn Ala Ala Met Phe Glu Ala Asn Gly Gly Cys Gly Tyr Val Leu
1825                1830                1835                1840
Lys Pro Pro Val Leu Trp Asp Lys Asn Cys Pro Met Tyr Gln Lys Phe
                1845                1850                1855    
Ser Pro Leu Glu Arg Asp Leu Asp Ser Met Asp Pro Ala Val Tyr Ser
            1860                1865                1870        
Leu Thr Ile Val Ser Gly Gln Asn Val Cys Pro Ser Asn Ser Met Gly
        1875                1880                1885            
Ser Pro Cys Ile Glu Val Asp Val Leu Gly Met Pro Leu Asp Ser Cys
    1890                1895                1900                
His Phe Arg Thr Lys Pro Ile His Arg Asn Thr Leu Asn Pro Met Trp
1905                1910                1915                1920
Asn Glu Gln Phe Leu Phe Arg Val His Phe Glu Asp Leu Val Phe Leu
                1925                1930                1935    
Arg Phe Ala Val Val Glu Asn Asn Ser Ser Ala Val Thr Ala Gln Arg
            1940                1945                1950        
Ile Ile Pro Leu Lys Ala Leu Lys Arg Gly Tyr Arg His Leu Gln Leu
        1955                1960                1965            
Arg Asn Leu His Asn Glu Val Leu Glu Ile Ser Ser Leu Phe Ile Asn
    1970                1975                1980                
Ser Arg Arg Met Glu Glu Asn Ser Ser Gly Asn Thr Met Ser Ala Ser
1985                1990                1995                2000
Ser Met Phe Asn Thr Glu Glu Arg Lys Cys Leu Gln Thr His Arg Val
                2005                2010                2015    
Thr Val His Gly Val Pro Gly Pro Glu Pro Phe Thr Val Phe Thr Ile
            2020                2025                2030        
Asn Gly Gly Thr Lys Ala Lys Gln Leu Leu Gln Gln Ile Leu Thr Asn
        2035                2040                2045            
Glu Gln Asp Ile Lys Pro Val Thr Thr Asp Tyr Phe Leu Met Glu Glu
    2050                2055                2060                
Lys Tyr Phe Ile Ser Lys Glu Lys Asn Glu Cys Arg Lys Gln Pro Phe
2065                2070                2075                2080
Gln Arg Ala Ile Gly Pro Glu Glu Glu Ile Met Gln Ile Leu Ser Ser
                2085                2090                2095    
Trp Phe Pro Glu Glu Gly Tyr Met Gly Arg Ile Val Leu Lys Thr Gln
            2100                2105                2110        
Gln Glu Asn Leu Glu Glu Lys Asn Ile Val Gln Asp Asp Lys Glu Val
        2115                2120                2125            
Ile Leu Ser Ser Glu Glu Glu Ser Phe Phe Val Gln Val His Asp Val
    2130                2135                2140                
Ser Pro Glu Gln Pro Arg Thr Val Ile Lys Ala Pro Arg Val Ser Thr
2145                2150                2155                2160
Ala Gln Asp Val Ile Gln Gln Thr Leu Cys Lys Ala Lys Tyr Ser Tyr
                2165                2170                2175    
Ser Ile Leu Ser Asn Pro Asn Pro Ser Asp Tyr Val Leu Leu Glu Glu
            2180                2185                2190        
Val Val Lys Asp Thr Thr Asn Lys Lys Thr Thr Thr Pro Lys Ser Ser
        2195                2200                2205            
Gln Arg Val Leu Leu Asp Gln Glu Cys Val Phe Gln Ala Gln Ser Lys
    2210                2215                2220                
Trp Lys Gly Ala Gly Lys Phe Ile Leu Lys Leu Lys Glu Gln Val Gln
2225                2230                2235                2240
Ala Ser Arg Glu Asp Lys Lys Lys Gly Ile Ser Phe Ala Ser Glu Leu
                2245                2250                2255    
Lys Lys Leu Thr Lys Ser Thr Lys Gln Pro Arg Gly Leu Thr Ser Pro
            2260                2265                2270        
Ser Gln Leu Leu Thr Ser Glu Ser Ile Gln Thr Lys Glu Glu Lys Pro
        2275                2280                2285            
Val Gly Gly Leu Ser Pro Val Thr Gln Trp Ile Thr Asp Ser Asp
    2290                2295                2300            


<210> 7640
<211> 1994
<212> PRT
<213> Homo sapiens

<400> 7640
Met Val Ser Glu Gly Ser Ala Ala Gly Arg Asp Phe Ala Gly Met Glu
 1               5                  10                  15      
Glu Val Arg Gln Leu His Val Arg Phe Cys Lys Gly Ile Lys Ile Trp
            20                  25                  30          
His Gln Ala Trp Phe Leu Cys Ser Leu Leu Gly Arg Glu Pro Gln Glu
        35                  40                  45              
Arg Glu Ala Gly Cys Gln Leu Trp Leu Cys Thr Leu Ser Ala Val Leu
    50                  55                  60                  
Lys Val Gly Trp Pro Phe Pro Leu Ser Glu Val Pro Asn Phe Thr Leu
65                  70                  75                  80  
Leu Lys Asp Gly Cys Gly Cys Trp Arg Leu Lys Glu Asp Gln Ile Tyr
                85                  90                  95      
Asn Ala Val Arg Arg Glu Glu Thr Glu Asn Thr Val Gly Ser Leu Leu
            100                 105                 110         
His Phe Leu Thr Lys Leu Pro Ala Ser Glu Thr Ala His Gly Arg Ile
        115                 120                 125             
Ser Val Gly Pro Cys Leu Lys Gln Cys Val Arg Asp Thr Val Cys Glu
    130                 135                 140                 
Tyr Arg Ala Thr Leu Gln Arg Thr Ser Ile Ser Gln Tyr Ile Thr Gly
145                 150                 155                 160 
Ser Leu Leu Glu Ala Thr Thr Ser Leu Gly Ala Arg Ser Gly Leu Leu
                165                 170                 175     
Ser Thr Phe Gly Gly Ser Thr Gly Arg Met Met Leu Lys Glu Arg Gln
            180                 185                 190         
Pro Ser Pro Ser Val Ala Asn Ser Asn Ala Leu Pro Ser Ser Ser Ala
        195                 200                 205             
Gly Ile Ser Lys Glu Leu Ile Asp Leu Gln Pro Leu Ile Gln Phe Pro
    210                 215                 220                 
Glu Glu Val Ala Ser Ile Leu Met Glu Gln Glu Gln Thr Ile Tyr Arg
225                 230                 235                 240 
Arg Val Leu Pro Val Asp Tyr Leu Cys Phe Leu Thr Arg Asp Leu Gly
                245                 250                 255     
Thr Pro Glu Cys Gln Ser Ser Leu Pro Cys Leu Lys Ala Ser Ile Ser
            260                 265                 270         
Ala Ser Ile Leu Thr Thr Gln Asn Gly Glu His Asn Ala Leu Glu Asp
        275                 280                 285             
Leu Val Met Arg Phe Asn Glu Val Ser Ser Trp Val Thr Trp Leu Ile
    290                 295                 300                 
Leu Thr Ala Gly Ser Met Glu Glu Lys Arg Glu Val Phe Ser Tyr Leu
305                 310                 315                 320 
Val His Val Ala Lys Cys Cys Trp Asn Met Gly Asn Tyr Asn Ala Val
                325                 330                 335     
Met Glu Phe Leu Ala Gly Leu Arg Ser Arg Lys Val Leu Lys Met Trp
            340                 345                 350         
Gln Phe Met Asp Gln Ser Asp Ile Glu Thr Met Arg Ser Leu Lys Asp
        355                 360                 365             
Ala Met Ala Gln His Glu Ser Ser Cys Glu Tyr Arg Lys Val Val Thr
    370                 375                 380                 
Arg Ala Leu His Ile Pro Gly Cys Lys Val Phe Pro Phe Cys Gly Val
385                 390                 395                 400 
Phe Leu Lys Glu Leu Cys Glu Val Leu Asp Gly Ala Ser Gly Leu Met
                405                 410                 415     
Lys Leu Cys Pro Arg Tyr Asn Ser Gln Glu Glu Thr Leu Glu Phe Val
            420                 425                 430         
Ala Asp Tyr Ser Gly Gln Asp Asn Phe Leu Gln Arg Val Gly Gln Asn
        435                 440                 445             
Gly Leu Lys Asn Ser Glu Lys Glu Ser Thr Val Asn Ser Ile Phe Gln
    450                 455                 460                 
Val Ile Arg Ser Cys Asn Arg Ser Leu Glu Thr Asp Glu Glu Asp Ser
465                 470                 475                 480 
Pro Ser Glu Gly Asn Ser Ser Arg Lys Ser Ser Leu Lys Asp Lys Ser
                485                 490                 495     
Arg Trp Gln Phe Ile Ile Gly Asp Leu Leu Asp Ser Asp Asn Asp Ile
            500                 505                 510         
Phe Glu Gln Ser Lys Glu Tyr Asp Ser His Gly Ser Glu Asp Ser Gln
        515                 520                 525             
Lys Ala Phe Asp His Gly Thr Glu Leu Ile Pro Trp Tyr Val Leu Ser
    530                 535                 540                 
Ile Gln Ala Asp Val His Gln Phe Leu Leu Gln Gly Ala Thr Val Ile
545                 550                 555                 560 
His Tyr Asp Gln Asp Thr His Leu Ser Ala Arg Cys Phe Leu Gln Leu
                565                 570                 575     
Gln Pro Asp Asn Ser Thr Leu Thr Trp Val Lys Pro Thr Thr Ala Ser
            580                 585                 590         
Pro Ala Ser Ser Lys Ala Lys Leu Gly Val Leu Asn Asn Thr Ala Glu
        595                 600                 605             
Pro Gly Lys Phe Pro Leu Leu Gly Asn Ala Gly Leu Ser Ser Leu Thr
    610                 615                 620                 
Glu Gly Val Leu Asp Leu Phe Ala Val Lys Ala Val Tyr Met Gly His
625                 630                 635                 640 
Pro Gly Ile Asp Ile His Thr Val Cys Val Gln Asn Lys Leu Gly Ser
                645                 650                 655     
Met Phe Leu Ser Glu Thr Gly Val Thr Leu Leu Tyr Gly Leu Gln Thr
            660                 665                 670         
Thr Asp Asn Arg Leu Leu His Phe Val Ala Pro Lys His Thr Ala Lys
        675                 680                 685             
Met Leu Phe Ser Gly Leu Leu Glu Leu Thr Arg Ala Val Arg Lys Met
    690                 695                 700                 
Arg Lys Phe Pro Asp Gln Arg Gln Gln Trp Leu Arg Lys Gln Tyr Val
705                 710                 715                 720 
Ser Leu Tyr Gln Glu Asp Gly Arg Tyr Glu Gly Pro Thr Leu Ala His
                725                 730                 735     
Ala Val Glu Leu Phe Gly Gly Arg Arg Trp Ser Ala Arg Asn Pro Ser
            740                 745                 750         
Pro Gly Thr Ser Ala Lys Asn Ala Glu Lys Pro Asn Met Gln Arg Asn
        755                 760                 765             
Asn Thr Leu Gly Ile Ser Thr Thr Lys Lys Lys Lys Lys Ile Leu Met
    770                 775                 780                 
Arg Gly Glu Ser Gly Glu Val Thr Asp Asp Glu Met Ala Thr Arg Lys
785                 790                 795                 800 
Ala Lys Met His Lys Glu Cys Arg Ser Arg Ser Gly Ser Asp Pro Gln
                805                 810                 815     
Asp Ile Asn Glu Gln Glu Glu Ser Lys Val Asn Ala Ile Ala Asn Pro
            820                 825                 830         
Pro Asn Pro Leu Pro Ser Arg Arg Ala His Ser Leu Thr Thr Ala Gly
        835                 840                 845             
Ser Pro Asn Leu Ala Ala Gly Thr Ser Ser Pro Ile Arg Pro Val Ser
    850                 855                 860                 
Ser Pro Val Leu Ser Ser Ser Asn Lys Ser Pro Ser Ser Ala Trp Ser
865                 870                 875                 880 
Ser Ser Ser Trp His Gly Arg Ile Lys Gly Gly Met Lys Gly Phe Gln
                885                 890                 895     
Ser Phe Met Val Ser Asp Ser Asn Met Ser Phe Val Glu Phe Val Glu
            900                 905                 910         
Leu Phe Lys Ser Phe Ser Val Arg Ser Arg Lys Asp Leu Lys Asp Leu
        915                 920                 925             
Phe Asp Val Tyr Ala Val Pro Cys Asn Arg Ser Gly Ser Glu Ser Ala
    930                 935                 940                 
Pro Leu Tyr Thr Asn Leu Thr Ile Asp Glu Asn Thr Ser Asp Leu Gln
945                 950                 955                 960 
Pro Asp Leu Asp Leu Leu Thr Arg Asn Val Ser Asp Leu Gly Leu Phe
                965                 970                 975     
Ile Lys Ser Lys Gln Gln Leu Ser Asp Asn Gln Arg Gln Ile Ser Asp
            980                 985                 990         
Ala Ile Ala Ala Ala Ser Ile Val Thr Asn Gly Thr Gly Ile Glu Ser
        995                 1000                1005            
Thr Ser Leu Gly Ile Phe Gly Val Gly Ile Leu Gln Leu Asn Asp Phe
    1010                1015                1020                
Leu Val Asn Cys Gln Gly Glu His Cys Thr Tyr Asp Glu Ile Leu Ser
1025                1030                1035                1040
Ile Ile Gln Lys Phe Glu Pro Ser Ile Ser Met Cys His Gln Gly Leu
                1045                1050                1055    
Met Ser Phe Glu Gly Phe Ala Arg Phe Leu Met Asp Lys Glu Asn Phe
            1060                1065                1070        
Ala Ser Lys Asn Asp Glu Ser Gln Glu Asn Ile Lys Glu Leu Gln Leu
        1075                1080                1085            
Pro Leu Ser Tyr Tyr Tyr Ile Glu Ser Ser His Asn Thr Tyr Leu Thr
    1090                1095                1100                
Gly His Gln Leu Lys Gly Glu Ser Ser Val Glu Leu Tyr Ser Gln Val
1105                1110                1115                1120
Leu Leu Gln Gly Cys Arg Ser Val Glu Leu Asp Cys Trp Asp Gly Asp
                1125                1130                1135    
Asp Gly Met Pro Ile Ile Tyr His Gly His Thr Leu Thr Thr Lys Ile
            1140                1145                1150        
Pro Phe Lys Glu Val Val Glu Ala Ile Asp Arg Ser Ala Phe Ile Asn
        1155                1160                1165            
Ser Asp Leu Pro Ile Ile Ile Ser Ile Glu Asn His Cys Ser Leu Pro
    1170                1175                1180                
Gln Gln Arg Lys Met Ala Glu Ile Phe Lys Thr Val Phe Gly Glu Lys
1185                1190                1195                1200
Leu Val Thr Lys Phe Leu Phe Glu Thr Asp Phe Ser Asp Asp Pro Met
                1205                1210                1215    
Leu Pro Ser Pro Asp Gln Leu Arg Lys Lys Val Leu Leu Lys Asn Lys
            1220                1225                1230        
Lys Leu Lys Ala His Gln Thr Pro Val Asp Ile Leu Lys Gln Lys Ala
        1235                1240                1245            
His Gln Leu Ala Ser Met Gln Val Gln Ala Tyr Asn Gly Gly Asn Ala
    1250                1255                1260                
Asn Pro Gln Pro Ala Asn Asn Glu Glu Glu Glu Asp Glu Glu Asp Glu
1265                1270                1275                1280
Tyr Asp Tyr Asp Tyr Glu Ser Leu Ser Asp Asp Asn Ile Leu Glu Asp
                1285                1290                1295    
Arg Pro Glu Asn Lys Ser Cys Asn Asp Lys Leu Gln Phe Glu Tyr Asn
            1300                1305                1310        
Glu Glu Ile Pro Lys Arg Ile Lys Lys Ala Asp Asn Ser Ala Cys Asn
        1315                1320                1325            
Lys Gly Lys Val Tyr Asp Met Glu Leu Gly Glu Glu Phe Tyr Leu Asp
    1330                1335                1340                
Gln Asn Lys Lys Glu Ser Arg Gln Ile Ala Pro Glu Leu Ser Asp Leu
1345                1350                1355                1360
Val Ile Tyr Cys Gln Ala Val Lys Phe Pro Gly Leu Ser Thr Leu Asn
                1365                1370                1375    
Ala Ser Gly Ser Ser Arg Gly Lys Glu Arg Lys Ser Arg Lys Ser Ile
            1380                1385                1390        
Phe Gly Asn Asn Pro Gly Arg Met Ser Pro Gly Glu Thr Ala Ser Phe
        1395                1400                1405            
Asn Lys Thr Ser Gly Lys Ser Ser Cys Glu Gly Ile Arg Gln Thr Trp
    1410                1415                1420                
Glu Glu Ser Ser Ser Pro Leu Asn Pro Thr Thr Ser Leu Ser Ala Ile
1425                1430                1435                1440
Ile Arg Thr Pro Lys Cys Tyr His Ile Ser Ser Leu Asn Glu Asn Ala
                1445                1450                1455    
Ala Lys Arg Leu Cys Arg Arg Tyr Ser Gln Lys Leu Thr Gln His Thr
            1460                1465                1470        
Ala Cys Gln Leu Leu Arg Thr Tyr Pro Ala Ala Thr Arg Ile Asp Ser
        1475                1480                1485            
Ser Asn Pro Asn Pro Leu Met Phe Trp Leu His Gly Ile Gln Leu Val
    1490                1495                1500                
Ala Leu Asn Tyr Gln Thr Asp Asp Leu Pro Leu His Leu Asn Ala Ala
1505                1510                1515                1520
Met Phe Glu Ala Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro Pro Val
                1525                1530                1535    
Leu Trp Asp Lys Asn Cys Pro Met Tyr Gln Lys Phe Ser Pro Leu Glu
            1540                1545                1550        
Arg Asp Leu Asp Ser Met Asp Pro Ala Val Tyr Ser Leu Thr Ile Val
        1555                1560                1565            
Ser Gly Gln Asn Val Cys Pro Ser Asn Ser Met Gly Ser Pro Cys Ile
    1570                1575                1580                
Glu Val Asp Val Leu Gly Met Pro Leu Asp Ser Cys His Phe Arg Thr
1585                1590                1595                1600
Lys Pro Ile His Arg Asn Thr Leu Asn Pro Met Trp Asn Glu Gln Phe
                1605                1610                1615    
Leu Phe His Val His Phe Glu Asp Leu Val Phe Leu Arg Phe Ala Val
            1620                1625                1630        
Val Glu Asn Asn Ser Ser Ala Val Thr Ala Gln Arg Ile Ile Pro Leu
        1635                1640                1645            
Lys Ala Leu Lys Arg Gly Tyr Arg His Leu Gln Leu Arg Asn Leu His
    1650                1655                1660                
Asn Glu Val Leu Glu Ile Ser Ser Leu Phe Ile Asn Ser Arg Arg Met
1665                1670                1675                1680
Glu Glu Asn Ser Ser Gly Asn Thr Met Ser Ala Ser Ser Met Phe Asn
                1685                1690                1695    
Thr Glu Glu Arg Lys Cys Leu Gln Thr His Arg Val Thr Val His Gly
            1700                1705                1710        
Val Pro Gly Pro Glu Pro Phe Thr Val Phe Thr Ile Asn Gly Gly Thr
        1715                1720                1725            
Lys Ala Lys Gln Leu Leu Gln Gln Ile Leu Thr Asn Glu Gln Asp Ile
    1730                1735                1740                
Lys Pro Val Thr Thr Asp Tyr Phe Leu Met Glu Glu Lys Tyr Phe Ile
1745                1750                1755                1760
Ser Lys Glu Lys Asn Glu Cys Arg Lys Gln Pro Phe Gln Arg Ala Ile
                1765                1770                1775    
Gly Pro Glu Glu Glu Ile Met Gln Ile Leu Ser Ser Trp Phe Pro Glu
            1780                1785                1790        
Glu Gly Tyr Met Gly Arg Ile Val Leu Lys Thr Gln Gln Glu Asn Leu
        1795                1800                1805            
Glu Glu Lys Asn Ile Val Gln Asp Asp Lys Glu Val Ile Leu Ser Ser
    1810                1815                1820                
Glu Glu Glu Ser Phe Phe Val Gln Val His Asp Val Ser Pro Glu Gln
1825                1830                1835                1840
Pro Arg Thr Val Ile Lys Ala Pro Arg Val Ser Thr Ala Gln Asp Val
                1845                1850                1855    
Ile Gln Gln Thr Leu Cys Lys Ala Lys Tyr Ser Tyr Ser Ile Leu Ser
            1860                1865                1870        
Asn Pro Asn Pro Ser Asp Tyr Val Leu Leu Glu Glu Val Val Lys Asp
        1875                1880                1885            
Thr Thr Asn Lys Lys Thr Thr Thr Pro Lys Ser Ser Gln Arg Val Leu
    1890                1895                1900                
Leu Asp Gln Glu Cys Val Phe Gln Ala Gln Ser Lys Trp Lys Gly Ala
1905                1910                1915                1920
Gly Lys Phe Ile Leu Lys Leu Lys Glu Gln Val Gln Ala Ser Arg Glu
                1925                1930                1935    
Asp Lys Lys Lys Gly Ile Ser Phe Ala Ser Glu Leu Lys Lys Leu Thr
            1940                1945                1950        
Lys Ser Thr Lys Gln Pro Arg Gly Leu Thr Ser Pro Ser Gln Leu Leu
        1955                1960                1965            
Thr Ser Glu Ser Ile Gln Thr Lys Glu Glu Lys Pro Val Gly Gly Leu
    1970                1975                1980                
Ser Ser Ser Asp Thr Met Asp Tyr Arg Gln
1985                1990                


<210> 7641
<211> 406
<212> PRT
<213> Homo sapiens

<400> 7641
Met Thr Leu Asp Val Gly Pro Glu Asp Glu Leu Pro Asp Trp Ala Ala
 1               5                  10                  15      
Ala Lys Glu Phe Tyr Gln Lys Tyr Asp Pro Lys Asp Val Ile Gly Arg
            20                  25                  30          
Gly Val Ser Ser Val Val Arg Arg Cys Val His Arg Ala Thr Gly His
        35                  40                  45              
Glu Phe Ala Val Lys Ile Met Glu Val Thr Ala Glu Arg Leu Ser Pro
    50                  55                  60                  
Glu Gln Leu Glu Glu Val Arg Glu Ala Thr Arg Arg Glu Thr His Ile
65                  70                  75                  80  
Leu Arg Gln Val Ala Gly His Pro His Ile Ile Thr Leu Ile Asp Ser
                85                  90                  95      
Tyr Glu Ser Ser Ser Phe Met Phe Leu Val Phe Asp Leu Met Arg Lys
            100                 105                 110         
Gly Glu Leu Phe Asp Tyr Leu Thr Glu Lys Val Ala Leu Ser Glu Lys
        115                 120                 125             
Glu Thr Arg Ser Ile Met Arg Ser Leu Leu Glu Ala Val Ser Phe Leu
    130                 135                 140                 
His Ala Asn Asn Ile Val His Arg Asp Leu Lys Pro Glu Asn Ile Leu
145                 150                 155                 160 
Leu Asp Asp Asn Met Gln Ile Arg Leu Ser Asp Phe Gly Phe Ser Cys
                165                 170                 175     
His Leu Glu Pro Gly Glu Lys Leu Arg Glu Leu Cys Gly Thr Pro Gly
            180                 185                 190         
Tyr Leu Ala Pro Glu Ile Leu Lys Cys Ser Met Asp Glu Thr His Pro
        195                 200                 205             
Gly Tyr Gly Lys Glu Val Asp Leu Trp Ala Cys Gly Val Ile Leu Phe
    210                 215                 220                 
Thr Leu Leu Ala Gly Ser Pro Pro Phe Trp His Arg Arg Gln Ile Leu
225                 230                 235                 240 
Met Leu Arg Met Ile Met Glu Gly Gln Tyr Gln Phe Ser Ser Pro Glu
                245                 250                 255     
Trp Asp Asp Arg Ser Ser Thr Val Lys Asp Leu Ile Ser Arg Leu Leu
            260                 265                 270         
Gln Val Asp Pro Glu Ala Arg Leu Thr Ala Glu Gln Ala Leu Gln His
        275                 280                 285             
Pro Phe Phe Glu Arg Cys Glu Gly Ser Gln Pro Trp Asn Leu Thr Pro
    290                 295                 300                 
Arg Gln Arg Phe Arg Val Ala Val Trp Thr Val Leu Ala Ala Gly Arg
305                 310                 315                 320 
Val Ala Leu Ser Thr His Arg Val Arg Pro Leu Thr Lys Asn Ala Leu
                325                 330                 335     
Leu Arg Asp Pro Tyr Ala Leu Arg Ser Val Arg His Leu Ile Asp Asn
            340                 345                 350         
Cys Ala Phe Arg Leu Tyr Gly His Trp Val Lys Lys Gly Glu Gln Gln
        355                 360                 365             
Asn Arg Ala Ala Leu Phe Gln His Arg Pro Pro Gly Pro Phe Pro Ile
    370                 375                 380                 
Met Gly Pro Glu Glu Glu Gly Asp Ser Ala Ala Ile Thr Glu Asp Glu
385                 390                 395                 400 
Ala Val Leu Val Leu Gly
                405     


<210> 7642
<211> 261
<212> PRT
<213> Homo sapiens

<400> 7642
Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu
 1               5                  10                  15      
Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser
            20                  25                  30          
Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val
        35                  40                  45              
Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg
    50                  55                  60                  
Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys
65                  70                  75                  80  
Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala
                85                  90                  95      
Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser
            100                 105                 110         
Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile
        115                 120                 125             
Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe
    130                 135                 140                 
Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile
145                 150                 155                 160 
Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly
                165                 170                 175     
Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu
            180                 185                 190         
Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala
        195                 200                 205             
Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr
    210                 215                 220                 
Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys
225                 230                 235                 240 
Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu
                245                 250                 255     
Asp Glu Glu Gly Ser
            260     


<210> 7643
<211> 568
<212> PRT
<213> Homo sapiens

<400> 7643
Met Gly Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu
 1               5                  10                  15      
Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asn Leu Cys Lys Asn Val
            20                  25                  30          
Ile Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ala Val Ser
        35                  40                  45              
Lys Gln Asp Leu Ile Thr Cys Leu Glu Gln Glu Lys Glu Pro Leu Thr
    50                  55                  60                  
Val Lys Arg His Glu Met Val Asn Glu Pro Pro Val Met Cys Ser His
65                  70                  75                  80  
Phe Ala Gln Glu Phe Trp Pro Glu Gln Asn Ile Lys Asp Ser Phe Glu
                85                  90                  95      
Lys Val Thr Leu Arg Arg Tyr Glu Lys Cys Gly Asn Asp Asn Phe Gln
            100                 105                 110         
Leu Lys Gly Cys Lys Ser Val Asp Glu Cys Lys Val His Lys Gly Gly
        115                 120                 125             
Tyr Asn Gly Leu Asn Gln Cys Leu Pro Thr Met Gln Ser Lys Met Phe
    130                 135                 140                 
Gln Cys Asp Glu Tyr Val Lys Val Phe Asn Lys Phe Ser His Ser Asp
145                 150                 155                 160 
Arg His Lys Ile Lys His Met Glu Asn Lys Pro Phe Lys Cys Lys Glu
                165                 170                 175     
Cys Gly Arg Ser Phe Cys Met Leu Ser His Leu Thr Arg His Glu Arg
            180                 185                 190         
Asn Tyr Thr Lys Val Asn Phe Cys Lys Cys Glu Glu Cys Glu Lys Ala
        195                 200                 205             
Val Asn Gln Ser Ser Lys Leu Thr Lys His Lys Arg Ile Tyr Thr Cys
    210                 215                 220                 
Glu Lys Leu Tyr Lys Cys Gln Glu Cys Asp Arg Thr Phe Asn Gln Phe
225                 230                 235                 240 
Ser Asn Leu Thr Glu Tyr Lys Lys Asp Tyr Ala Arg Glu Lys Pro Tyr
                245                 250                 255     
Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser His Leu Thr
            260                 265                 270         
Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
        275                 280                 285             
Cys Gly Lys Ala Ser Asn Gln Phe Ser Asn Leu Thr Thr His Lys Lys
    290                 295                 300                 
Ile His Thr Gly Glu Gln Pro Tyr Ile Cys Glu Glu Cys Gly Lys Ala
305                 310                 315                 320 
Phe Thr Gln Ser Ser Thr Leu Thr Thr His Lys Arg Ile His Thr Gly
                325                 330                 335     
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser
            340                 345                 350         
Ser Lys Leu Thr Glu His Lys Asn Ile His Thr Gly Glu Gln Pro Tyr
        355                 360                 365             
Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Asn Leu Thr
    370                 375                 380                 
Glu His Arg Lys Ile His Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu
385                 390                 395                 400 
Cys Gly Lys Ala Phe Lys His Ser Ser Ala Leu Thr Thr His Lys Arg
                405                 410                 415     
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
            420                 425                 430         
Phe Asn Arg Ser Ser Lys Leu Thr Glu Tyr Lys Lys Leu His Thr Gly
        435                 440                 445             
Lys Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ile Gln Ser
    450                 455                 460                 
Ser Lys Leu Thr Glu His Lys Lys Ile His Ser Gly Glu Ile Pro Tyr
465                 470                 475                 480 
Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys His Ser Ser Ser Leu Thr
                485                 490                 495     
Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
            500                 505                 510         
Cys Ser Lys Ala Phe Ser Arg Ser Ser Lys Leu Thr Glu His Lys Ile
        515                 520                 525             
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Arg Cys Asp Lys Ala
    530                 535                 540                 
Phe Asn Gln Ser Ala Asn Leu Thr Lys His Lys Lys Ile His Thr Gly
545                 550                 555                 560 
Glu Lys Leu Gln Asn Trp Asn Val
                565             


<210> 7644
<211> 540
<212> PRT
<213> Homo sapiens

<400> 7644
Met Gly Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu
 1               5                  10                  15      
Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asn Leu Tyr Lys Asn Val
            20                  25                  30          
Ile Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ala Val Ser
        35                  40                  45              
Lys Gln Asp Leu Ile Thr Cys Leu Glu Gln Glu Lys Glu Pro Leu Thr
    50                  55                  60                  
Val Lys Arg His Glu Met Val Asn Glu Pro Pro Val Met Cys Ser His
65                  70                  75                  80  
Phe Ala Gln Glu Phe Trp Pro Glu Gln Asn Ile Lys Asp Ser Phe Glu
                85                  90                  95      
Lys Val Thr Leu Arg Arg Tyr Glu Lys Cys Gly Asn Asp Asn Phe Gln
            100                 105                 110         
Leu Lys Gly Cys Lys Ser Val Asp Glu Cys Lys Val His Lys Gly Gly
        115                 120                 125             
Tyr Asn Gly Leu Asn Gln Cys Leu Pro Thr Met Gln Ser Lys Met Phe
    130                 135                 140                 
Gln Cys Asp Lys Tyr Val Lys Val Phe Asn Lys Phe Ser His Ser Asp
145                 150                 155                 160 
Arg His Lys Ile Lys His Met Glu Asn Lys Pro Phe Lys Cys Lys Glu
                165                 170                 175     
Cys Gly Arg Ser Phe Cys Met Leu Ser His Leu Thr Arg His Lys Arg
            180                 185                 190         
Ile Tyr Thr Cys Glu Lys Leu Tyr Lys Cys Gln Glu Cys Asp Arg Thr
        195                 200                 205             
Phe Asn Gln Phe Ser Asn Leu Thr Glu Tyr Lys Lys Asp Tyr Ala Arg
    210                 215                 220                 
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser
225                 230                 235                 240 
Ser His Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr
                245                 250                 255     
Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Phe Ser Asn Leu Thr
            260                 265                 270         
Thr His Lys Lys Ile His Thr Gly Glu Gln Pro Tyr Ile Cys Glu Glu
        275                 280                 285             
Cys Gly Lys Ala Phe Thr Gln Ser Ser Thr Leu Thr Thr His Lys Arg
    290                 295                 300                 
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
305                 310                 315                 320 
Phe Asn Arg Ser Ser Lys Leu Thr Glu His Lys Asn Ile His Thr Gly
                325                 330                 335     
Glu Gln Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser
            340                 345                 350         
Ser Asn Leu Thr Glu His Arg Lys Ile His Thr Glu Glu Lys Pro Tyr
        355                 360                 365             
Lys Cys Lys Glu Cys Gly Lys Ala Phe Lys His Ser Ser Ala Leu Thr
    370                 375                 380                 
Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
385                 390                 395                 400 
Cys Gly Lys Ala Phe Asn Arg Ser Ser Lys Leu Thr Glu His Lys Lys
                405                 410                 415     
Leu His Thr Gly Lys Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
            420                 425                 430         
Phe Ile Gln Ser Ser Lys Leu Thr Glu His Lys Lys Ile His Ser Gly
        435                 440                 445             
Glu Ile Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys His Ser
    450                 455                 460                 
Ser Ser Leu Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr
465                 470                 475                 480 
Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Arg Ser Ser Lys Leu Thr
                485                 490                 495     
Glu His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Arg
            500                 505                 510         
Cys Asp Lys Ala Phe Asn Gln Ser Ala Asn Leu Thr Lys His Lys Lys
        515                 520                 525             
Ile His Thr Gly Glu Lys Leu Gln Asn Trp Asn Val
    530                 535                 540 


<210> 7645
<211> 160
<212> PRT
<213> Homo sapiens

<400> 7645
Met Ser Tyr Asn Cys Cys Ser Arg Asn Phe Ser Ser Arg Ser Phe Gly
 1               5                  10                  15      
Gly Tyr Leu Tyr Tyr Pro Gly Ser Tyr Pro Ser Ser Leu Val Tyr Ser
            20                  25                  30          
Thr Ala Leu Cys Ser Pro Ser Thr Cys Gln Leu Arg Ser Ser Leu Tyr
        35                  40                  45              
Arg Asp Cys Gln Lys Thr Cys Trp Glu Pro Ala Ser Cys Gln Lys Ser
    50                  55                  60                  
Cys Tyr Arg Pro Arg Thr Ser Ile Leu Cys Cys Pro Cys Gln Thr Thr
65                  70                  75                  80  
Cys Ser Gly Ser Leu Gly Phe Arg Ser Ser Ser Cys Arg Ser Gln Gly
                85                  90                  95      
Tyr Gly Ser Arg Cys Cys Tyr Ser Leu Gly Asn Gly Ser Ser Gly Phe
            100                 105                 110         
Arg Phe Leu Lys Tyr Gly Gly Cys Gly Phe Pro Ser Leu Ser Tyr Gly
        115                 120                 125             
Ser Arg Phe Cys Tyr Pro Asn Tyr Leu Ala Ser Gly Ala Trp Gln Ser
    130                 135                 140                 
Ser Cys Tyr Arg Pro Ile Cys Gly Ser Arg Phe Tyr Gln Phe Thr Cys
145                 150                 155                 160 


<210> 7646
<211> 1738
<212> PRT
<213> Homo sapiens

<400> 7646
Met Ser Asp Phe Val Glu Ser Glu Ala Glu Glu Ser Glu Glu Glu Tyr
 1               5                  10                  15      
Asn Asp Glu Gly Glu Val Val Pro Arg Val Thr Lys Lys Phe Val Glu
            20                  25                  30          
Glu Glu Asp Asp Asp Glu Glu Glu Glu Glu Glu Asn Leu Asp Asp Gln
        35                  40                  45              
Asp Glu Gln Gly Asn Leu Lys Gly Phe Ile Asn Asp Asp Asp Asp Glu
    50                  55                  60                  
Asp Glu Gly Glu Glu Asp Glu Gly Ser Asp Ser Gly Asp Ser Glu Asp
65                  70                  75                  80  
Asp Val Gly His Lys Lys Arg Lys Arg Thr Ser Phe Asp Asp Arg Leu
                85                  90                  95      
Glu Asp Asp Asp Phe Asp Leu Ile Glu Glu Asn Leu Gly Val Lys Val
            100                 105                 110         
Lys Arg Gly Gln Lys Tyr Arg Arg Val Lys Lys Met Ser Asp Asp Glu
        115                 120                 125             
Asp Asp Asp Glu Glu Glu Tyr Gly Lys Glu Glu His Glu Lys Glu Ala
    130                 135                 140                 
Ile Ala Glu Glu Ile Phe Gln Asp Gly Glu Gly Glu Glu Gly Gln Glu
145                 150                 155                 160 
Ala Met Glu Ala Pro Met Ala Pro Pro Glu Glu Glu Glu Glu Asp Asp
                165                 170                 175     
Glu Glu Ser Asp Ile Asp Asp Phe Ile Val Asp Asp Asp Gly Gln Pro
            180                 185                 190         
Leu Lys Lys Pro Lys Trp Arg Lys Lys Leu Pro Gly Tyr Thr Asp Ala
        195                 200                 205             
Ala Leu Gln Glu Ala Gln Glu Ile Phe Gly Val Asp Phe Asp Tyr Asp
    210                 215                 220                 
Glu Phe Glu Lys Tyr Asn Glu Tyr Asp Glu Glu Leu Glu Glu Glu Tyr
225                 230                 235                 240 
Glu Tyr Glu Asp Asp Glu Ala Glu Gly Glu Ile Arg Val Arg Pro Lys
                245                 250                 255     
Lys Thr Thr Lys Lys Arg Val Ser Arg Arg Ser Ile Phe Glu Met Tyr
            260                 265                 270         
Glu Pro Ser Glu Leu Glu Ser Ser His Leu Thr Asp Gln Asp Asn Glu
        275                 280                 285             
Ile Arg Ala Thr Asp Leu Pro Glu Arg Phe Gln Leu Arg Ser Ile Pro
    290                 295                 300                 
Val Lys Gly Ala Glu Asp Asp Glu Leu Glu Glu Glu Ala Asp Trp Ile
305                 310                 315                 320 
Tyr Arg Asn Ala Phe Ala Thr Pro Thr Ile Ser Leu Gln Glu Ser Cys
                325                 330                 335     
Asp Tyr Leu Asp Arg Gly Gln Pro Ala Ser Ser Phe Ser Arg Lys Gly
            340                 345                 350         
Pro Ser Thr Ile Gln Lys Ile Lys Glu Ala Leu Gly Phe Met Arg Asn
        355                 360                 365             
Gln His Phe Glu Val Pro Phe Ile Ala Phe Tyr Arg Lys Glu Tyr Val
    370                 375                 380                 
Glu Pro Glu Leu His Ile Asn Asp Leu Trp Arg Val Trp Gln Trp Asp
385                 390                 395                 400 
Glu Lys Trp Thr Gln Leu Arg Ile Arg Lys Glu Asn Leu Thr Arg Leu
                405                 410                 415     
Phe Glu Lys Met Gln Ala Tyr Gln Tyr Glu Gln Ile Ser Ala Asp Pro
            420                 425                 430         
Asp Lys Pro Leu Ala Asp Gly Ile Arg Ala Leu Asp Thr Thr Asp Met
        435                 440                 445             
Glu Arg Leu Lys Asp Val Gln Ser Met Asp Glu Leu Lys Asp Val Tyr
    450                 455                 460                 
Asn His Phe Leu Leu Tyr Tyr Gly Arg Asp Ile Pro Lys Met Gln Asn
465                 470                 475                 480 
Ala Ala Lys Ala Ser Arg Lys Lys Leu Lys Arg Val Arg Glu Glu Gly
                485                 490                 495     
Asp Glu Glu Gly Glu Gly Asp Glu Ala Glu Asp Glu Glu Gln Arg Gly
            500                 505                 510         
Pro Glu Leu Lys Gln Ala Ser Arg Arg Asp Met Tyr Thr Ile Cys Gln
        515                 520                 525             
Ser Ala Gly Leu Asp Gly Leu Ala Lys Lys Phe Gly Leu Thr Pro Glu
    530                 535                 540                 
Gln Phe Gly Glu Asn Leu Arg Asp Ser Tyr Gln Arg His Glu Thr Glu
545                 550                 555                 560 
Gln Phe Pro Ala Glu Pro Leu Glu Leu Ala Lys Asp Tyr Val Cys Ser
                565                 570                 575     
Gln Phe Pro Thr Pro Glu Ala Val Leu Glu Gly Ala Arg Tyr Met Val
            580                 585                 590         
Ala Leu Gln Ile Ala Arg Glu Pro Leu Val Arg Gln Val Leu Arg Gln
        595                 600                 605             
Thr Phe Gln Glu Arg Ala Lys Leu Asn Ile Thr Pro Thr Lys Lys Gly
    610                 615                 620                 
Arg Lys Asp Val Asp Glu Ala His Tyr Ala Tyr Ser Phe Lys Tyr Leu
625                 630                 635                 640 
Lys Asn Lys Pro Val Lys Glu Leu Arg Asp Asp Gln Phe Leu Lys Ile
                645                 650                 655     
Cys Leu Ala Glu Asp Glu Gly Leu Leu Thr Thr Asp Ile Ser Ile Asp
            660                 665                 670         
Leu Lys Gly Val Glu Gly Tyr Gly Asn Asp Gln Thr Tyr Phe Glu Glu
        675                 680                 685             
Ile Lys Gln Phe Tyr Tyr Arg Asp Glu Phe Ser His Gln Val Gln Glu
    690                 695                 700                 
Trp Asn Arg Gln Arg Thr Met Ala Ile Glu Arg Ala Leu Gln Gln Phe
705                 710                 715                 720 
Leu Tyr Val Gln Met Ala Lys Glu Leu Lys Asn Lys Leu Leu Ala Glu
                725                 730                 735     
Ala Lys Glu Tyr Val Ile Lys Ala Cys Ser Arg Lys Leu Tyr Asn Trp
            740                 745                 750         
Leu Arg Val Ala Pro Tyr Arg Pro Asp Gln Gln Val Glu Glu Asp Asp
        755                 760                 765             
Asp Phe Met Asp Glu Asn Gln Gly Lys Gly Ile Arg Val Leu Gly Ile
    770                 775                 780                 
Ala Phe Ser Ser Ala Arg Asp His Pro Val Phe Cys Ala Leu Val Asn
785                 790                 795                 800 
Gly Glu Gly Glu Val Thr Asp Phe Leu Arg Leu Pro His Phe Thr Lys
                805                 810                 815     
Arg Arg Thr Ala Trp Arg Glu Glu Glu Arg Glu Lys Lys Ala Lys Pro
            820                 825                 830         
Phe Ser Phe Asn Phe Leu Ser Ile Gln Ala Gln Asp Ile Glu Thr Leu
        835                 840                 845             
Lys Lys Phe Leu Leu Asn Lys Lys Pro His Val Val Thr Val Ala Gly
    850                 855                 860                 
Glu Asn Arg Asp Ala Gln Met Leu Ile Glu Asp Val Lys Arg Ile Val
865                 870                 875                 880 
His Glu Leu Asp Gln Gly Gln Gln Leu Ser Ser Ile Gly Val Glu Leu
                885                 890                 895     
Val Asp Asn Glu Leu Ala Ile Leu Tyr Met Asn Ser Lys Lys Ser Glu
            900                 905                 910         
Ala Glu Phe Arg Asp Tyr Pro Pro Val Leu Arg Gln Ala Val Ser Leu
        915                 920                 925             
Ala Arg Arg Ile Gln Asp Pro Leu Ile Glu Phe Ala Gln Val Cys Ser
    930                 935                 940                 
Ser Asp Glu Asp Ile Leu Cys Leu Lys Phe His Pro Leu Gln Glu His
945                 950                 955                 960 
Val Val Lys Glu Glu Leu Leu Asn Ala Leu Tyr Cys Glu Phe Ile Asn
                965                 970                 975     
Arg Val Asn Glu Val Gly Val Asp Val Asn Arg Ala Ile Ala His Pro
            980                 985                 990         
Tyr Ser Gln Ala Leu Ile Gln Tyr Val Cys Gly Leu Gly Pro Arg Lys
        995                 1000                1005            
Gly Thr His Leu Leu Lys Ile Leu Lys Gln Asn Asn Thr Arg Leu Glu
    1010                1015                1020                
Ser Arg Thr Gln Leu Val Thr Met Cys His Met Gly Pro Lys Val Phe
1025                1030                1035                1040
Met Asn Cys Ala Gly Phe Leu Lys Ile Asp Thr Ala Ser Leu Gly Asp
                1045                1050                1055    
Ser Thr Asp Ser Tyr Ile Glu Val Leu Asp Gly Ser Arg Val His Pro
            1060                1065                1070        
Glu Thr Tyr Glu Trp Ala Arg Lys Met Ala Val Asp Ala Leu Glu Tyr
        1075                1080                1085            
Asp Glu Ser Ala Glu Asp Ala Asn Pro Ala Gly Ala Leu Glu Glu Ile
    1090                1095                1100                
Leu Glu Asn Pro Glu Arg Leu Lys Asp Leu Asp Leu Asp Ala Phe Ala
1105                1110                1115                1120
Glu Glu Leu Glu Arg Gln Gly Tyr Gly Asp Lys His Ile Thr Leu Tyr
                1125                1130                1135    
Asp Ile Arg Ala Glu Leu Ser Cys Arg Tyr Lys Asp Leu Arg Thr Ala
            1140                1145                1150        
Tyr Arg Ser Pro Asn Thr Glu Glu Ile Phe Asn Met Leu Thr Lys Glu
        1155                1160                1165            
Thr Pro Glu Thr Phe Tyr Ile Gly Lys Leu Ile Ile Cys Asn Val Thr
    1170                1175                1180                
Gly Ile Ala His Arg Arg Pro Gln Gly Glu Ser Tyr Asp Gln Ala Ile
1185                1190                1195                1200
Arg Asn Asp Glu Thr Gly Leu Trp Gln Cys Pro Phe Cys Gln Gln Asp
                1205                1210                1215    
Asn Phe Pro Glu Leu Ser Glu Val Trp Asn His Phe Asp Ser Gly Ser
            1220                1225                1230        
Cys Pro Gly Gln Ala Ile Gly Val Lys Thr Arg Leu Asp Asn Gly Val
        1235                1240                1245            
Thr Gly Phe Ile Pro Thr Lys Phe Leu Ser Asp Lys Val Val Lys Arg
    1250                1255                1260                
Pro Glu Glu Arg Val Lys Val Gly Met Thr Val His Cys Arg Ile Met
1265                1270                1275                1280
Lys Ile Asp Ile Glu Lys Phe Ser Ala Asp Leu Thr Cys Arg Thr Ser
                1285                1290                1295    
Asp Leu Met Asp Arg Asn Asn Glu Trp Lys Leu Pro Lys Asp Thr Tyr
            1300                1305                1310        
Tyr Asp Phe Asp Ala Glu Ala Ala Asp His Lys Gln Glu Glu Asp Met
        1315                1320                1325            
Lys Arg Lys Gln Gln Arg Thr Thr Tyr Ile Lys Arg Val Ile Ala His
    1330                1335                1340                
Pro Ser Phe His Asn Ile Asn Phe Lys Gln Ala Glu Lys Met Met Glu
1345                1350                1355                1360
Thr Met Asp Gln Gly Asp Val Ile Ile Arg Pro Ser Ser Lys Gly Glu
                1365                1370                1375    
Asn His Leu Thr Val Thr Trp Lys Val Ser Asp Gly Ile Tyr Gln His
            1380                1385                1390        
Val Asp Val Arg Glu Glu Gly Lys Glu Asn Ala Phe Ser Leu Gly Ala
        1395                1400                1405            
Thr Leu Trp Ile Asn Ser Glu Glu Phe Glu Asp Leu Asp Glu Ile Val
    1410                1415                1420                
Ala Arg Tyr Val Gln Pro Met Ala Ser Phe Ala Arg Asp Leu Leu Asn
1425                1430                1435                1440
His Lys Tyr Tyr Gln Asp Cys Ser Gly Gly Asp Arg Lys Lys Leu Glu
                1445                1450                1455    
Glu Leu Leu Ile Lys Thr Lys Lys Glu Lys Pro Thr Phe Ile Pro Tyr
            1460                1465                1470        
Phe Ile Cys Ala Cys Lys Glu Leu Pro Gly Lys Phe Leu Leu Gly Tyr
        1475                1480                1485            
Gln Pro Arg Gly Lys Pro Arg Ile Glu Tyr Val Thr Val Thr Pro Glu
    1490                1495                1500                
Gly Phe Arg Tyr Arg Gly Gln Ile Phe Pro Thr Val Asn Gly Leu Phe
1505                1510                1515                1520
Arg Trp Phe Lys Asp His Tyr Gln Asp Pro Val Pro Gly Ile Thr Pro
                1525                1530                1535    
Ser Ser Ser Ser Arg Thr Arg Thr Pro Ala Ser Ile Asn Ala Thr Pro
            1540                1545                1550        
Ala Asn Ile Asn Leu Ala Asp Leu Thr Arg Ala Val Asn Ala Leu Pro
        1555                1560                1565            
Gln Asn Met Thr Ser Gln Met Phe Ser Ala Ile Ala Ala Val Thr Gly
    1570                1575                1580                
Gln Gly Gln Asn Pro Asn Ala Thr Pro Ala Gln Trp Ala Ser Ser Gln
1585                1590                1595                1600
Tyr Gly Tyr Gly Gly Ser Gly Gly Gly Ser Ser Ala Tyr His Val Phe
                1605                1610                1615    
Pro Thr Pro Ala Gln Gln Pro Val Ala Thr Pro Leu Met Thr Pro Ser
            1620                1625                1630        
Tyr Ser Tyr Thr Thr Pro Ser Gln Pro Ile Thr Thr Pro Gln Tyr His
        1635                1640                1645            
Gln Leu Gln Ala Ser Thr Thr Pro Gln Ser Ala Gln Ala Gln Pro Gln
    1650                1655                1660                
Pro Ser Ser Ser Ser Arg Gln Arg Gln Gln Gln Pro Lys Ser Asn Ser
1665                1670                1675                1680
His Ala Ala Ile Asp Trp Gly Lys Met Ala Glu Gln Trp Leu Gln Glu
                1685                1690                1695    
Lys Glu Ala Glu Arg Arg Lys Gln Lys Gln Arg Leu Thr Pro Arg Pro
            1700                1705                1710        
Ser Pro Ser Pro Met Ile Glu Ser Thr Pro Met Ser Ile Ala Gly Asp
        1715                1720                1725            
Ala Thr Pro Leu Leu Asp Glu Met Asp Arg
    1730                1735            


<210> 7647
<211> 1726
<212> PRT
<213> Homo sapiens

<400> 7647
Met Ser Asp Phe Val Glu Ser Glu Ala Glu Glu Ser Glu Glu Glu Tyr
 1               5                  10                  15      
Asn Asp Glu Gly Glu Val Val Pro Arg Val Thr Lys Lys Phe Val Glu
            20                  25                  30          
Glu Glu Asp Asp Asp Glu Glu Glu Glu Glu Glu Asn Leu Asp Asp Gln
        35                  40                  45              
Asp Glu Gln Gly Asn Leu Lys Gly Phe Ile Asn Asp Asp Asp Asp Glu
    50                  55                  60                  
Asp Glu Gly Glu Glu Asp Glu Gly Ser Asp Ser Gly Asp Ser Glu Asp
65                  70                  75                  80  
Asp Val Gly His Lys Lys Arg Lys Arg Thr Ser Phe Asp Asp Arg Leu
                85                  90                  95      
Glu Asp Asp Asp Phe Asp Leu Ile Glu Glu Asn Leu Gly Val Lys Val
            100                 105                 110         
Lys Arg Gly Gln Lys Tyr Arg Arg Val Lys Lys Met Ser Asp Asp Glu
        115                 120                 125             
Asp Asp Asp Glu Glu Glu Tyr Gly Lys Glu Glu His Glu Lys Glu Ala
    130                 135                 140                 
Ile Ala Glu Glu Ile Phe Gln Asp Gly Glu Gly Glu Glu Gly Gln Glu
145                 150                 155                 160 
Ala Met Glu Ala Pro Met Ala Pro Pro Glu Glu Glu Glu Glu Asp Asp
                165                 170                 175     
Glu Glu Ser Asp Ile Asp Asp Phe Ile Val Asp Asp Asp Gly Gln Pro
            180                 185                 190         
Leu Lys Lys Pro Lys Trp Arg Lys Lys Leu Pro Gly Tyr Thr Asp Ala
        195                 200                 205             
Ala Leu Gln Glu Ala Gln Glu Ile Phe Gly Val Asp Phe Asp Tyr Asp
    210                 215                 220                 
Glu Phe Glu Lys Tyr Asn Glu Tyr Asp Glu Glu Leu Glu Glu Glu Tyr
225                 230                 235                 240 
Glu Tyr Glu Asp Asp Glu Ala Glu Gly Glu Ile Arg Val Arg Pro Lys
                245                 250                 255     
Lys Thr Thr Lys Lys Arg Val Ser Arg Arg Ser Ile Phe Glu Met Tyr
            260                 265                 270         
Glu Pro Ser Glu Leu Glu Ser Ser His Leu Thr Asp Gln Asp Asn Glu
        275                 280                 285             
Ile Arg Ala Thr Asp Leu Pro Glu Arg Phe Gln Leu Arg Ser Ile Pro
    290                 295                 300                 
Val Lys Gly Ala Glu Asp Asp Glu Leu Glu Glu Glu Ala Asp Trp Ile
305                 310                 315                 320 
Tyr Arg Asn Ala Phe Ala Thr Pro Thr Ile Ser Leu Gln Glu Ser Cys
                325                 330                 335     
Asp Tyr Leu Asp Arg Gly Gln Pro Ala Ser Ser Phe Ser Arg Lys Gly
            340                 345                 350         
Pro Ser Thr Ile Gln Lys Ile Lys Glu Ala Leu Gly Phe Met Arg Asn
        355                 360                 365             
Gln His Phe Glu Val Pro Phe Ile Ala Phe Tyr Arg Lys Glu Tyr Val
    370                 375                 380                 
Glu Pro Glu Leu His Ile Asn Asp Leu Trp Arg Val Trp Gln Trp Asp
385                 390                 395                 400 
Glu Lys Trp Thr Gln Leu Arg Ile Arg Lys Glu Asn Leu Thr Arg Leu
                405                 410                 415     
Phe Glu Lys Met Gln Ala Tyr Gln Tyr Glu Gln Ile Ser Ala Asp Pro
            420                 425                 430         
Asp Lys Pro Leu Ala Asp Gly Ile Arg Ala Leu Asp Thr Thr Asp Met
        435                 440                 445             
Glu Arg Leu Lys Asp Val Gln Ser Met Asp Glu Leu Lys Asp Val Tyr
    450                 455                 460                 
Asn His Phe Leu Leu Tyr Tyr Gly Arg Asp Ile Pro Lys Met Gln Asn
465                 470                 475                 480 
Ala Ala Lys Ala Ser Arg Lys Lys Leu Lys Arg Val Arg Glu Glu Gly
                485                 490                 495     
Asp Glu Glu Gly Glu Gly Asp Glu Ala Glu Asp Glu Glu Gln Arg Gly
            500                 505                 510         
Pro Glu Leu Lys Gln Ala Ser Arg Arg Asp Met Tyr Thr Ile Cys Gln
        515                 520                 525             
Ser Ala Gly Leu Asp Gly Leu Ala Lys Lys Phe Gly Leu Thr Pro Glu
    530                 535                 540                 
Gln Phe Gly Glu Asn Leu Arg Asp Ser Tyr Gln Arg His Glu Thr Glu
545                 550                 555                 560 
Gln Phe Pro Ala Glu Pro Leu Glu Leu Ala Lys Asp Tyr Val Cys Ser
                565                 570                 575     
Gln Phe Pro Thr Pro Glu Ala Val Leu Glu Gly Ala Arg Tyr Met Val
            580                 585                 590         
Ala Leu Gln Ile Ala Arg Glu Pro Leu Val Arg Gln Val Leu Arg Gln
        595                 600                 605             
Thr Phe Gln Glu Arg Ala Lys Leu Asn Ile Thr Pro Thr Lys Lys Gly
    610                 615                 620                 
Arg Lys Asp Val Asp Glu Ala His Tyr Ala Tyr Ser Phe Lys Tyr Leu
625                 630                 635                 640 
Lys Asn Lys Pro Val Lys Glu Leu Arg Asp Asp Gln Phe Leu Lys Ile
                645                 650                 655     
Cys Leu Ala Glu Asp Glu Gly Leu Leu Thr Thr Asp Ile Ser Ile Asp
            660                 665                 670         
Leu Lys Gly Val Glu Gly Tyr Gly Asn Asp Gln Thr Tyr Phe Glu Glu
        675                 680                 685             
Ile Lys Gln Phe Tyr Tyr Arg Asp Glu Phe Ser His Gln Val Gln Glu
    690                 695                 700                 
Trp Asn Arg Gln Arg Thr Met Ala Ile Glu Arg Ala Leu Gln Gln Phe
705                 710                 715                 720 
Leu Tyr Val Gln Met Ala Lys Glu Leu Lys Asn Lys Leu Leu Ala Glu
                725                 730                 735     
Ala Lys Glu Tyr Val Ile Lys Ala Cys Ser Arg Lys Leu Tyr Asn Trp
            740                 745                 750         
Leu Arg Val Ala Pro Tyr Arg Pro Asp Gln Gln Val Glu Glu Asp Asp
        755                 760                 765             
Asp Phe Met Asp Glu Asn Gln Gly Lys Gly Ile Arg Val Leu Gly Ile
    770                 775                 780                 
Ala Phe Ser Ser Ala Arg Asp His Pro Val Phe Cys Ala Leu Val Asn
785                 790                 795                 800 
Gly Glu Gly Glu Val Thr Asp Phe Leu Arg Leu Pro His Phe Thr Lys
                805                 810                 815     
Arg Arg Thr Ala Trp Arg Glu Glu Glu Arg Glu Lys Lys Ala Gln Asp
            820                 825                 830         
Ile Glu Thr Leu Lys Lys Phe Leu Leu Asn Lys Lys Pro His Val Val
        835                 840                 845             
Thr Val Ala Gly Glu Asn Arg Asp Ala Gln Met Leu Ile Glu Asp Val
    850                 855                 860                 
Lys Arg Ile Val His Glu Leu Asp Gln Gly Gln Gln Leu Ser Ser Ile
865                 870                 875                 880 
Gly Val Glu Leu Val Asp Asn Glu Leu Ala Ile Leu Tyr Met Asn Ser
                885                 890                 895     
Lys Lys Ser Glu Ala Glu Phe Arg Asp Tyr Pro Pro Val Leu Arg Gln
            900                 905                 910         
Ala Val Ser Leu Ala Arg Arg Ile Gln Asp Pro Leu Ile Glu Phe Ala
        915                 920                 925             
Gln Val Cys Ser Ser Asp Glu Asp Ile Leu Cys Leu Lys Phe His Pro
    930                 935                 940                 
Leu Gln Glu His Val Val Lys Glu Glu Leu Leu Asn Ala Leu Tyr Cys
945                 950                 955                 960 
Glu Phe Ile Asn Arg Val Asn Glu Val Gly Val Asp Val Asn Arg Ala
                965                 970                 975     
Ile Ala His Pro Tyr Ser Gln Ala Leu Ile Gln Tyr Val Cys Gly Leu
            980                 985                 990         
Gly Pro Arg Lys Gly Thr His Leu Leu Lys Ile Leu Lys Gln Asn Asn
        995                 1000                1005            
Thr Arg Leu Glu Ser Arg Thr Gln Leu Val Thr Met Cys His Met Gly
    1010                1015                1020                
Pro Lys Val Phe Met Asn Cys Ala Gly Phe Leu Lys Ile Asp Thr Ala
1025                1030                1035                1040
Ser Leu Gly Asp Ser Thr Asp Ser Tyr Ile Glu Val Leu Asp Gly Ser
                1045                1050                1055    
Arg Val His Pro Glu Thr Tyr Glu Trp Ala Arg Lys Met Ala Val Asp
            1060                1065                1070        
Ala Leu Glu Tyr Asp Glu Ser Ala Glu Asp Ala Asn Pro Ala Gly Ala
        1075                1080                1085            
Leu Glu Glu Ile Leu Glu Asn Pro Glu Arg Leu Lys Asp Leu Asp Leu
    1090                1095                1100                
Asp Ala Phe Ala Glu Glu Leu Glu Arg Gln Gly Tyr Gly Asp Lys His
1105                1110                1115                1120
Ile Thr Leu Tyr Asp Ile Arg Ala Glu Leu Ser Cys Arg Tyr Lys Asp
                1125                1130                1135    
Leu Arg Thr Ala Tyr Arg Ser Pro Asn Thr Glu Glu Ile Phe Asn Met
            1140                1145                1150        
Leu Thr Lys Glu Thr Pro Glu Thr Phe Tyr Ile Gly Lys Leu Ile Ile
        1155                1160                1165            
Cys Asn Val Thr Gly Ile Ala His Arg Arg Pro Gln Gly Glu Ser Tyr
    1170                1175                1180                
Asp Gln Ala Ile Arg Asn Asp Glu Thr Gly Leu Trp Gln Cys Pro Phe
1185                1190                1195                1200
Cys Gln Gln Asp Asn Phe Pro Glu Leu Ser Glu Val Trp Asn His Phe
                1205                1210                1215    
Asp Ser Gly Ser Cys Pro Gly Gln Ala Ile Gly Val Lys Thr Arg Leu
            1220                1225                1230        
Asp Asn Gly Val Thr Gly Phe Ile Pro Thr Lys Phe Leu Ser Asp Lys
        1235                1240                1245            
Val Val Lys Arg Pro Glu Glu Arg Val Lys Val Gly Met Thr Val His
    1250                1255                1260                
Cys Arg Ile Met Lys Ile Asp Ile Glu Lys Phe Ser Ala Asp Leu Thr
1265                1270                1275                1280
Cys Arg Thr Ser Asp Leu Met Asp Arg Asn Asn Glu Trp Lys Leu Pro
                1285                1290                1295    
Lys Asp Thr Tyr Tyr Asp Phe Asp Ala Glu Ala Ala Asp His Lys Gln
            1300                1305                1310        
Glu Glu Asp Met Lys Arg Lys Gln Gln Arg Thr Thr Tyr Ile Lys Arg
        1315                1320                1325            
Val Ile Ala His Pro Ser Phe His Asn Ile Asn Phe Lys Gln Ala Glu
    1330                1335                1340                
Lys Met Met Glu Thr Met Asp Gln Gly Asp Val Ile Ile Arg Pro Ser
1345                1350                1355                1360
Ser Lys Gly Glu Asn His Leu Thr Val Thr Trp Lys Val Ser Asp Gly
                1365                1370                1375    
Ile Tyr Gln His Val Asp Val Arg Glu Glu Gly Lys Glu Asn Ala Phe
            1380                1385                1390        
Ser Leu Gly Ala Thr Leu Trp Ile Asn Ser Glu Glu Phe Glu Asp Leu
        1395                1400                1405            
Asp Glu Ile Val Ala Arg Tyr Val Gln Pro Met Ala Ser Phe Ala Arg
    1410                1415                1420                
Asp Leu Leu Asn His Lys Tyr Tyr Gln Asp Cys Ser Gly Gly Asp Arg
1425                1430                1435                1440
Lys Lys Leu Glu Glu Leu Leu Ile Lys Thr Lys Lys Glu Lys Pro Thr
                1445                1450                1455    
Phe Ile Pro Tyr Phe Ile Cys Ala Cys Lys Glu Leu Pro Gly Lys Phe
            1460                1465                1470        
Leu Leu Gly Tyr Gln Pro Arg Gly Lys Pro Arg Ile Glu Tyr Val Thr
        1475                1480                1485            
Val Thr Pro Glu Gly Phe Arg Tyr Arg Gly Gln Ile Phe Pro Thr Val
    1490                1495                1500                
Asn Gly Leu Phe Arg Trp Phe Lys Asp His Tyr Gln Asp Pro Val Pro
1505                1510                1515                1520
Gly Ile Thr Pro Ser Ser Ser Ser Arg Thr Arg Thr Pro Ala Ser Ile
                1525                1530                1535    
Asn Ala Thr Pro Ala Asn Ile Asn Leu Ala Asp Leu Thr Arg Ala Val
            1540                1545                1550        
Asn Ala Leu Pro Gln Asn Met Thr Ser Gln Met Phe Ser Ala Ile Ala
        1555                1560                1565            
Ala Val Thr Gly Gln Gly Gln Asn Pro Asn Ala Thr Pro Ala Gln Trp
    1570                1575                1580                
Ala Ser Ser Gln Tyr Gly Tyr Gly Gly Ser Gly Gly Gly Ser Ser Ala
1585                1590                1595                1600
Tyr His Val Phe Pro Thr Pro Ala Gln Gln Pro Val Ala Thr Pro Leu
                1605                1610                1615    
Met Thr Pro Ser Tyr Ser Tyr Thr Thr Pro Ser Gln Pro Ile Thr Thr
            1620                1625                1630        
Pro Gln Tyr His Gln Leu Gln Ala Ser Thr Thr Pro Gln Ser Ala Gln
        1635                1640                1645            
Ala Gln Pro Gln Pro Ser Ser Ser Ser Arg Gln Arg Gln Gln Gln Pro
    1650                1655                1660                
Lys Ser Asn Ser His Ala Ala Ile Asp Trp Gly Lys Met Ala Glu Gln
1665                1670                1675                1680
Trp Leu Gln Glu Lys Glu Ala Glu Arg Arg Lys Gln Lys Gln Arg Leu
                1685                1690                1695    
Thr Pro Arg Pro Ser Pro Ser Pro Met Ile Glu Ser Thr Pro Met Ser
            1700                1705                1710        
Ile Ala Gly Asp Ala Thr Pro Leu Leu Asp Glu Met Asp Arg
        1715                1720                1725    


<210> 7648
<211> 345
<212> PRT
<213> Homo sapiens

<400> 7648
Met Ser Lys Pro Glu Trp Leu Ile Val Gly Glu Asp Asp Asp Asp Ala
 1               5                  10                  15      
Ala Phe Ala Pro Val Leu Cys Glu Thr Thr Ala Cys Gly Phe Pro Ala
            20                  25                  30          
Ala Gln Trp Gly Val Arg Gly Glu Thr Ser Cys Arg Ala Thr Pro Thr
        35                  40                  45              
Pro Ser Pro Ala Asn Ala His Val Asn Gly Ser Ala Asp Ala Pro Glu
    50                  55                  60                  
Asn Ala Leu His Leu Ala Glu Ala Gly Gly Leu Cys Gly Glu Ser Arg
65                  70                  75                  80  
Ala Arg Gly Gln Gln Arg Leu Leu His Ser Gly Gly Pro Gly Phe Gly
                85                  90                  95      
Arg Pro Pro Ile Gly Leu Ala Asp Trp Leu Thr Asp Thr Pro Arg Leu
            100                 105                 110         
Pro Pro Pro Pro Pro Val Pro Arg Pro Ala Ser Ser Leu Pro Pro Leu
        115                 120                 125             
Pro Gly Leu Gly Gly Arg Arg Gln Thr Glu Ala Pro Leu Ser Pro Arg
    130                 135                 140                 
Pro Ser Pro Arg Pro Phe Leu Phe Pro Ala Pro Arg Leu Leu Pro Gly
145                 150                 155                 160 
Ser Gly Ser Ser Cys Val Gly Gly Pro His Ser Ser Glu Arg Arg Glu
                165                 170                 175     
Glu Ala Ala Ser Arg Met Lys Cys Lys Pro Asn Gln Thr Arg Thr Tyr
            180                 185                 190         
Asp Pro Glu Gly Phe Lys Lys Arg Ala Ala Cys Leu Cys Phe Arg Ser
        195                 200                 205             
Glu Arg Glu Asp Glu Val Leu Leu Val Ser Ser Ser Arg Tyr Pro Asp
    210                 215                 220                 
Arg Trp Ile Val Pro Gly Gly Gly Met Glu Pro Glu Glu Glu Pro Gly
225                 230                 235                 240 
Gly Ala Ala Val Arg Glu Val Tyr Glu Glu Ala Gly Val Lys Gly Lys
                245                 250                 255     
Leu Gly Arg Leu Leu Gly Val Phe Glu Gln Asn Gln Asp Pro Lys His
            260                 265                 270         
Arg Thr Tyr Val Tyr Val Leu Thr Val Thr Glu Leu Leu Glu Asp Trp
        275                 280                 285             
Glu Asp Ser Val Ser Ile Gly Arg Lys Arg Glu Trp Phe Lys Val Glu
    290                 295                 300                 
Asp Ala Ile Lys Val Leu Gln Cys His Lys Pro Val His Ala Glu Tyr
305                 310                 315                 320 
Leu Glu Lys Leu Lys Leu Gly Gly Ser Pro Thr Asn Gly Asn Ser Met
                325                 330                 335     
Ala Pro Ser Ser Pro Asp Ser Asp Pro
            340                 345 


<210> 7649
<211> 1588
<212> PRT
<213> Homo sapiens

<400> 7649
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Glu Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Leu Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Met Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr
        755                 760                 765             
Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp
    770                 775                 780                 
Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val
785                 790                 795                 800 
Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu
                805                 810                 815     
Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn
            820                 825                 830         
Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser
        835                 840                 845             
Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser
    850                 855                 860                 
Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe
865                 870                 875                 880 
Pro Ser Leu Lys Gly Asn Arg Arg Ala Leu Val Asp Gln Lys Ser Ser
                885                 890                 895     
Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro Pro Ser Pro Gln
            900                 905                 910         
Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe Leu Lys Glu Val
        915                 920                 925             
Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp Leu Asn Met Lys
    930                 935                 940                 
Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg Val Phe Val Leu
945                 950                 955                 960 
Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp Ala Arg Gln Asp
                965                 970                 975     
Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr Lys Gly Met Leu
            980                 985                 990         
Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln Ser Tyr Ala His
        995                 1000                1005            
Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu Leu Glu Ile Ala
    1010                1015                1020                
Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg Lys Arg Ser Pro
1025                1030                1035                1040
Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp Pro Gly Leu Ala Gly
                1045                1050                1055    
Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val Pro Gln Leu Gly
            1060                1065                1070        
Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro Lys Glu Leu Asp Thr
        1075                1080                1085            
Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser Ile Gly Pro Glu Val
    1090                1095                1100                
Ile Lys Pro Val Phe Asp Leu Gly Glu Thr Glu Glu Lys Lys Ser Gln
1105                1110                1115                1120
Ile Ser Ala Asp Ser Gly Val Ser Leu Thr Ser Ser Ser Gln Arg Thr
                1125                1130                1135    
Asp Gln Asp Ser Val Ile Gly Val Ser Pro Ala Val Met Ile Arg Ser
            1140                1145                1150        
Ser Ser Gln Asp Ser Glu Val Ser Thr Val Val Ser Asn Ser Ser Gly
        1155                1160                1165            
Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser Ser Asn Ala Gly Asp Gly
    1170                1175                1180                
Pro Gly Gly Glu Gly Ser Val His Leu Ala Ser Ser Arg Gly Thr Leu
1185                1190                1195                1200
Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala Thr Ser Thr Ile Phe Gly
                1205                1210                1215    
Lys Ala His Ser Leu Lys Pro Ser Ile Lys Glu Lys Leu Ala Gly Ser
            1220                1225                1230        
Pro Ile Arg Thr Ser Glu Asp Val Ser Gln Arg Val Tyr Leu Tyr Glu
        1235                1240                1245            
Gly Leu Leu Gly Lys Glu Arg Ser Thr Leu Trp Asp Gln Met Gln Phe
    1250                1255                1260                
Trp Glu Asp Ala Phe Leu Asp Ala Val Met Leu Glu Arg Glu Gly Met
1265                1270                1275                1280
Gly Met Asp Gln Gly Pro Gln Glu Met Ile Asp Arg Tyr Leu Ser Leu
                1285                1290                1295    
Gly Glu His Asp Arg Lys Arg Leu Glu Asp Asp Glu Asp Arg Leu Leu
            1300                1305                1310        
Ala Thr Leu Leu His Asn Leu Ile Ser Tyr Met Leu Leu Met Lys Val
        1315                1320                1325            
Asn Lys Asn Asp Ile Arg Lys Lys Val Arg Arg Leu Met Gly Lys Ser
    1330                1335                1340                
His Ile Gly Leu Val Tyr Ser Gln Gln Ile Asn Glu Val Leu Asp Gln
1345                1350                1355                1360
Leu Ala Asn Leu Asn Gly Arg Asp Leu Ser Ile Trp Ser Ser Gly Ser
                1365                1370                1375    
Arg His Met Lys Lys Gln Thr Phe Val Val His Ala Gly Thr Asp Thr
            1380                1385                1390        
Asn Gly Asp Ile Phe Phe Met Glu Val Cys Asp Asp Cys Val Val Leu
        1395                1400                1405            
Arg Ser Asn Ile Gly Thr Val Tyr Glu Arg Trp Trp Tyr Glu Lys Leu
    1410                1415                1420                
Ile Asn Met Thr Tyr Cys Pro Lys Thr Lys Val Leu Cys Leu Trp Arg
1425                1430                1435                1440
Arg Asn Gly Ser Glu Thr Gln Leu Asn Lys Phe Tyr Thr Lys Lys Cys
                1445                1450                1455    
Arg Glu Leu Tyr Tyr Cys Val Lys Asp Ser Met Glu Arg Ala Ala Ala
            1460                1465                1470        
Arg Gln Gln Ser Ile Lys Pro Gly Pro Glu Leu Gly Gly Glu Phe Pro
        1475                1480                1485            
Val Gln Asp Leu Lys Thr Gly Glu Gly Gly Leu Leu Gln Val Thr Leu
    1490                1495                1500                
Glu Gly Ile Asn Leu Lys Phe Met His Asn Gln Val Phe Ile Glu Leu
1505                1510                1515                1520
Asn His Ile Lys Lys Cys Asn Thr Val Arg Gly Val Phe Val Leu Glu
                1525                1530                1535    
Glu Phe Val Pro Glu Ile Lys Glu Val Val Ser His Lys Tyr Lys Thr
            1540                1545                1550        
Pro Met Ala His Glu Ile Cys Tyr Ser Val Leu Cys Leu Phe Ser Tyr
        1555                1560                1565            
Val Ala Ala Val His Ser Ser Glu Glu Asp Leu Arg Thr Pro Pro Arg
    1570                1575                1580                
Pro Val Ser Ser
1585            


<210> 7650
<211> 1647
<212> PRT
<213> Homo sapiens

<400> 7650
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Gly Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Phe Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Leu Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Ala Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr
        755                 760                 765             
Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp
    770                 775                 780                 
Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val
785                 790                 795                 800 
Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu
                805                 810                 815     
Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn
            820                 825                 830         
Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser
        835                 840                 845             
Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser
    850                 855                 860                 
Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe
865                 870                 875                 880 
Pro Ser Leu Lys Val Phe Gly Leu Asn Thr Leu Met Glu Ile Val Thr
                885                 890                 895     
Glu Ala Gly Pro Gly Ser Gly Glu Gly Asn Arg Arg Ala Leu Val Asp
            900                 905                 910         
Gln Lys Ser Ser Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro
        915                 920                 925             
Pro Ser Pro Gln Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe
    930                 935                 940                 
Leu Lys Glu Val Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp
945                 950                 955                 960 
Leu Asn Met Lys Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg
                965                 970                 975     
Val Phe Val Leu Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp
            980                 985                 990         
Ala Arg Gln Asp Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr
        995                 1000                1005            
Lys Gly Met Leu Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln
    1010                1015                1020                
Ser Tyr Ala His Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu
1025                1030                1035                1040
Leu Glu Ile Ala Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg
                1045                1050                1055    
Lys Arg Ser Pro Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp Pro
            1060                1065                1070        
Gly Leu Ala Gly Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val
        1075                1080                1085            
Pro Gln Leu Gly Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro Lys
    1090                1095                1100                
Glu Leu Asp Thr Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser Ile
1105                1110                1115                1120
Glu Leu Trp Asn Lys His Gln Glu Val Lys Lys Gln Lys Ala Leu Glu
                1125                1130                1135    
Lys Gln Arg Pro Glu Val Ile Lys Pro Val Phe Asp Leu Gly Glu Thr
            1140                1145                1150        
Glu Glu Lys Lys Ser Gln Ile Ser Ala Asp Ser Gly Val Ser Leu Thr
        1155                1160                1165            
Ser Ser Ser Gln Arg Thr Asp Gln Asp Ser Val Ile Gly Val Ser Pro
    1170                1175                1180                
Ala Val Met Ile Arg Ser Ser Ser Gln Asp Ser Glu Val Ser Thr Val
1185                1190                1195                1200
Val Ser Asn Ser Ser Gly Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser
                1205                1210                1215    
Ser Asn Ala Gly Asp Gly Pro Gly Gly Glu Gly Ser Val His Leu Ala
            1220                1225                1230        
Ser Ser Arg Gly Thr Leu Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala
        1235                1240                1245            
Thr Ser Thr Ile Phe Gly Lys Ala His Ser Leu Lys Pro Cys Ile Lys
    1250                1255                1260                
Glu Lys Leu Ala Gly Ser Pro Ile Arg Thr Ser Glu Asp Val Ser Gln
1265                1270                1275                1280
Arg Val Tyr Leu Tyr Glu Gly Leu Leu Gly Arg Asp Lys Gly Ser Met
                1285                1290                1295    
Trp Asp Gln Leu Glu Asp Ala Ala Met Glu Thr Phe Ser Ile Ser Lys
            1300                1305                1310        
Glu Arg Ser Thr Leu Trp Asp Gln Met Gln Phe Trp Glu Asp Ala Phe
        1315                1320                1325            
Leu Asp Ala Val Met Leu Glu Arg Glu Gly Met Gly Met Asp Gln Gly
    1330                1335                1340                
Pro Gln Glu Met Ile Asp Arg Tyr Leu Ser Leu Gly Glu His Asp Arg
1345                1350                1355                1360
Lys Arg Leu Glu Asp Asp Glu Asp Arg Leu Leu Ala Thr Leu Leu His
                1365                1370                1375    
Asn Leu Ile Ser Tyr Met Leu Leu Met Lys Val Asn Lys Asn Asp Ile
            1380                1385                1390        
Arg Lys Lys Val Arg Arg Leu Met Gly Lys Ser His Ile Gly Leu Val
        1395                1400                1405            
Tyr Ser Gln Gln Ile Asn Glu Val Leu Asp Gln Leu Ala Asn Leu Asn
    1410                1415                1420                
Gly Arg Asp Leu Ser Ile Trp Ser Ser Gly Ser Arg His Met Lys Lys
1425                1430                1435                1440
Gln Thr Phe Val Val His Ala Gly Thr Asp Thr Asn Gly Asp Ile Phe
                1445                1450                1455    
Phe Met Glu Val Cys Asp Asp Cys Val Val Leu Arg Ser Asn Ile Gly
            1460                1465                1470        
Thr Val Tyr Glu Arg Trp Trp Tyr Glu Lys Leu Ile Asn Met Thr Tyr
        1475                1480                1485            
Cys Pro Lys Thr Lys Val Leu Cys Leu Trp Arg Arg Asn Gly Ser Glu
    1490                1495                1500                
Thr Gln Leu Asn Lys Phe Tyr Thr Lys Lys Cys Arg Glu Leu Tyr Tyr
1505                1510                1515                1520
Cys Val Lys Asp Ser Met Glu Arg Ala Ala Ala Arg Gln Gln Ser Ile
                1525                1530                1535    
Lys Pro Gly Pro Glu Leu Gly Gly Glu Phe Pro Val Gln Asp Leu Lys
            1540                1545                1550        
Thr Gly Glu Gly Gly Leu Leu Gln Val Thr Leu Glu Gly Ile Asn Leu
        1555                1560                1565            
Lys Phe Met His Asn Gln Val Phe Ile Glu Leu Asn His Ile Lys Lys
    1570                1575                1580                
Cys Asn Thr Val Arg Gly Val Phe Val Leu Glu Glu Phe Val Pro Glu
1585                1590                1595                1600
Ile Lys Glu Val Val Ser His Lys Tyr Lys Thr Pro Met Ala His Glu
                1605                1610                1615    
Ile Cys Tyr Ser Val Leu Cys Leu Phe Ser Tyr Val Ala Ala Val His
            1620                1625                1630        
Ser Ser Glu Glu Asp Leu Arg Thr Pro Pro Arg Pro Val Ser Ser
        1635                1640                1645        


<210> 7651
<211> 1581
<212> PRT
<213> Homo sapiens

<400> 7651
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Glu Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Leu Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr
        755                 760                 765             
Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp
    770                 775                 780                 
Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val
785                 790                 795                 800 
Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu
                805                 810                 815     
Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn
            820                 825                 830         
Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser
        835                 840                 845             
Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser
    850                 855                 860                 
Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe
865                 870                 875                 880 
Pro Ser Leu Lys Val Phe Gly Leu Asn Thr Leu Met Glu Ile Val Thr
                885                 890                 895     
Glu Ala Gly Pro Gly Ser Gly Glu Gly Asn Arg Arg Ala Leu Val Asp
            900                 905                 910         
Gln Lys Ser Ser Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro
        915                 920                 925             
Pro Ser Pro Gln Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe
    930                 935                 940                 
Leu Lys Glu Val Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp
945                 950                 955                 960 
Leu Asn Met Lys Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg
                965                 970                 975     
Val Phe Val Leu Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp
            980                 985                 990         
Ala Arg Gln Asp Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr
        995                 1000                1005            
Lys Gly Met Leu Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln
    1010                1015                1020                
Ser Tyr Ala His Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu
1025                1030                1035                1040
Leu Glu Ile Ala Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg
                1045                1050                1055    
Lys Arg Ser Pro Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp Pro
            1060                1065                1070        
Gly Leu Ala Gly Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val
        1075                1080                1085            
Pro Gln Leu Gly Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro Lys
    1090                1095                1100                
Glu Leu Asp Thr Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser Ile
1105                1110                1115                1120
Glu Leu Trp Asn Lys His Gln Glu Val Lys Lys Gln Lys Ala Leu Glu
                1125                1130                1135    
Lys Gln Arg Pro Glu Val Ile Lys Pro Val Phe Asp Leu Gly Glu Thr
            1140                1145                1150        
Glu Glu Lys Lys Ser Gln Ile Ser Ala Asp Ser Gly Val Ser Leu Thr
        1155                1160                1165            
Ser Ser Ser Gln Arg Thr Asp Gln Asp Ser Val Ile Gly Val Ser Pro
    1170                1175                1180                
Ala Val Met Ile Arg Ser Ser Ser Gln Asp Ser Glu Val Ser Thr Val
1185                1190                1195                1200
Val Ser Asn Ser Ser Gly Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser
                1205                1210                1215    
Ser Asn Ala Gly Asp Gly Pro Gly Gly Glu Gly Ser Val His Leu Ala
            1220                1225                1230        
Ser Ser Arg Gly Thr Leu Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala
        1235                1240                1245            
Thr Ser Thr Ile Phe Gly Lys Ala His Ser Leu Lys Pro Ser Ile Lys
    1250                1255                1260                
Glu Lys Leu Ala Gly Ser Pro Ile Arg Thr Ser Glu Asp Val Ser Gln
1265                1270                1275                1280
Arg Val Tyr Leu Tyr Glu Gly Leu Leu Gly Arg Asp Lys Gly Ser Met
                1285                1290                1295    
Trp Asp Gln Leu Glu Asp Ala Ala Met Glu Thr Phe Ser Ile Ser Lys
            1300                1305                1310        
Glu Arg Ser Thr Leu Trp Asp Gln Met Gln Phe Trp Glu Asp Ala Phe
        1315                1320                1325            
Leu Asp Ala Val Met Leu Glu Arg Glu Gly Met Gly Met Asp Gln Gly
    1330                1335                1340                
Pro Gln Glu Met Ile Asp Arg Tyr Leu Ser Leu Gly Glu His Asp Arg
1345                1350                1355                1360
Lys Arg Leu Glu Asp Asp Glu Asp Arg Leu Leu Ala Thr Leu Leu His
                1365                1370                1375    
Asn Leu Ile Ser Tyr Met Leu Leu Met Lys Val Asn Lys Asn Asp Ile
            1380                1385                1390        
Arg Lys Lys Val Arg Arg Leu Met Gly Lys Ser His Ile Gly Leu Val
        1395                1400                1405            
Tyr Ser Gln Gln Ile Asn Glu Val Leu Asp Gln Leu Ala Asn Leu Asn
    1410                1415                1420                
Gly Arg Asp Leu Ser Ile Trp Ser Ser Gly Ser Arg His Met Lys Lys
1425                1430                1435                1440
Gln Thr Phe Val Val His Ala Gly Thr Asp Thr Asn Gly Asp Ile Phe
                1445                1450                1455    
Phe Met Glu Val Cys Asp Asp Cys Val Val Leu Arg Ser Asn Ile Gly
            1460                1465                1470        
Thr Val Tyr Glu Arg Trp Trp Tyr Glu Lys Leu Ile Asn Met Thr Tyr
        1475                1480                1485            
Cys Pro Lys Thr Lys Val Leu Cys Leu Trp Arg Arg Asn Gly Ser Glu
    1490                1495                1500                
Thr Gln Leu Asn Lys Phe Tyr Thr Lys Lys Cys Arg Glu Leu Tyr Tyr
1505                1510                1515                1520
Cys Val Lys Asp Ser Met Glu Arg Ala Ala Ala Arg Gln Gln Ser Ile
                1525                1530                1535    
Lys Pro Gly Pro Glu Leu Gly Gly Glu Phe Pro Val Gln Asp Leu Lys
            1540                1545                1550        
Thr Gly Glu Gly Gly Leu Leu Gln Val Thr Leu Glu Gly Ile Asn Leu
        1555                1560                1565            
Lys Phe Met His Asn Gln Phe Leu Lys Leu Lys Lys Trp
    1570                1575                1580    


<210> 7652
<211> 1565
<212> PRT
<213> Homo sapiens

<400> 7652
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Gly Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Phe Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Leu Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Ala Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ala Gln Lys Leu Leu Arg Pro
        755                 760                 765             
Asn Ser Leu Arg Leu Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg
    770                 775                 780                 
Ala Ser Ser Pro Asn Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe
785                 790                 795                 800 
Gly Gly Ile Met Ser Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr
                805                 810                 815     
Ser Phe Ser Leu Ser Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu
            820                 825                 830         
Lys Ala Thr Pro Phe Pro Ser Leu Lys Val Phe Gly Leu Asn Thr Leu
        835                 840                 845             
Met Glu Ile Val Thr Glu Ala Gly Pro Gly Ser Gly Glu Gly Asn Arg
    850                 855                 860                 
Arg Ala Leu Val Asp Gln Lys Ser Ser Val Ile Lys His Ser Pro Thr
865                 870                 875                 880 
Val Lys Arg Glu Pro Pro Ser Pro Gln Gly Arg Ser Ser Asn Ser Ser
                885                 890                 895     
Glu Asn Gln Gln Phe Leu Lys Glu Val Val His Ser Val Leu Asp Gly
            900                 905                 910         
Gln Gly Val Gly Trp Leu Asn Met Lys Lys Val Arg Arg Leu Leu Glu
        915                 920                 925             
Ser Glu Gln Leu Arg Val Phe Val Leu Ser Lys Leu Asn Arg Met Val
    930                 935                 940                 
Gln Ser Glu Asp Asp Ala Arg Gln Asp Ile Ile Pro Asp Val Glu Ile
945                 950                 955                 960 
Ser Arg Lys Val Tyr Lys Gly Met Leu Asp Leu Leu Lys Cys Thr Val
                965                 970                 975     
Leu Ser Leu Glu Gln Ser Tyr Ala His Ala Gly Leu Gly Gly Met Ala
            980                 985                 990         
Ser Ile Phe Gly Leu Leu Glu Ile Ala Gln Thr His Tyr Tyr Ser Lys
        995                 1000                1005            
Glu Pro Asp Lys Arg Lys Arg Ser Pro Thr Glu Ser Val Asn Thr Pro
    1010                1015                1020                
Val Gly Lys Asp Pro Gly Leu Ala Gly Arg Gly Asp Pro Lys Ala Met
1025                1030                1035                1040
Ala Gln Leu Arg Val Pro Gln Leu Gly Pro Arg Ala Pro Ser Ala Thr
                1045                1050                1055    
Gly Lys Gly Pro Lys Glu Leu Asp Thr Arg Ser Leu Lys Glu Glu Asn
            1060                1065                1070        
Phe Ile Ala Ser Ile Gly Pro Glu Val Ile Lys Pro Val Phe Asp Leu
        1075                1080                1085            
Gly Glu Thr Glu Glu Lys Lys Ser Gln Ile Ser Ala Asp Ser Gly Val
    1090                1095                1100                
Ser Leu Thr Ser Ser Ser Gln Arg Thr Asp Gln Asp Ser Val Ile Gly
1105                1110                1115                1120
Val Ser Pro Ala Val Met Ile Arg Ser Ser Ser Gln Asp Ser Glu Val
                1125                1130                1135    
Ser Thr Val Val Ser Asn Ser Ser Gly Glu Thr Leu Gly Ala Asp Ser
            1140                1145                1150        
Asp Leu Ser Ser Asn Ala Gly Asp Gly Pro Gly Gly Glu Gly Ser Val
        1155                1160                1165            
His Leu Ala Ser Ser Arg Gly Thr Leu Ser Asp Ser Glu Ile Glu Thr
    1170                1175                1180                
Asn Ser Ala Thr Ser Thr Ile Phe Gly Lys Ala His Ser Leu Lys Pro
1185                1190                1195                1200
Cys Ile Lys Glu Lys Leu Ala Gly Ser Pro Ile Arg Thr Ser Glu Asp
                1205                1210                1215    
Val Ser Gln Arg Val Tyr Leu Tyr Glu Gly Leu Leu Gly Lys Glu Arg
            1220                1225                1230        
Ser Thr Leu Trp Asp Gln Met Gln Phe Trp Glu Asp Ala Phe Leu Asp
        1235                1240                1245            
Ala Val Met Leu Glu Arg Glu Gly Met Gly Met Asp Gln Gly Pro Gln
    1250                1255                1260                
Glu Met Ile Asp Arg Tyr Leu Ser Leu Gly Glu His Asp Arg Lys Arg
1265                1270                1275                1280
Leu Glu Asp Asp Glu Asp Arg Leu Leu Ala Thr Leu Leu His Asn Leu
                1285                1290                1295    
Ile Ser Tyr Met Leu Leu Met Lys Val Asn Lys Asn Asp Ile Arg Lys
            1300                1305                1310        
Lys Val Arg Arg Leu Met Gly Lys Ser His Ile Gly Leu Val Tyr Ser
        1315                1320                1325            
Gln Gln Ile Asn Glu Val Leu Asp Gln Leu Ala Asn Leu Asn Gly Arg
    1330                1335                1340                
Asp Leu Ser Ile Trp Ser Ser Gly Ser Arg His Met Lys Lys Gln Thr
1345                1350                1355                1360
Phe Val Val His Ala Gly Thr Asp Thr Asn Gly Asp Ile Phe Phe Met
                1365                1370                1375    
Glu Val Cys Asp Asp Cys Val Val Leu Arg Ser Asn Ile Gly Thr Val
            1380                1385                1390        
Tyr Glu Arg Trp Trp Tyr Glu Lys Leu Ile Asn Met Thr Tyr Cys Pro
        1395                1400                1405            
Lys Thr Lys Val Leu Cys Leu Trp Arg Arg Asn Gly Ser Glu Thr Gln
    1410                1415                1420                
Leu Asn Lys Phe Tyr Thr Lys Lys Cys Arg Glu Leu Tyr Tyr Cys Val
1425                1430                1435                1440
Lys Asp Ser Met Glu Arg Ala Ala Ala Arg Gln Gln Ser Ile Lys Pro
                1445                1450                1455    
Gly Pro Glu Leu Gly Gly Glu Phe Pro Val Gln Asp Leu Lys Thr Gly
            1460                1465                1470        
Glu Gly Gly Leu Leu Gln Val Thr Leu Glu Gly Ile Asn Leu Lys Phe
        1475                1480                1485            
Met His Asn Gln Val Phe Ile Glu Leu Asn His Ile Lys Lys Cys Asn
    1490                1495                1500                
Thr Val Arg Gly Val Phe Val Leu Glu Glu Phe Val Pro Glu Ile Lys
1505                1510                1515                1520
Glu Val Val Ser His Lys Tyr Lys Thr Pro Met Ala His Glu Ile Cys
                1525                1530                1535    
Tyr Ser Val Leu Cys Leu Phe Ser Tyr Val Ala Ala Val His Ser Ser
            1540                1545                1550        
Glu Glu Asp Leu Arg Thr Pro Pro Arg Pro Val Ser Ser
        1555                1560                1565


<210> 7653
<211> 1545
<212> PRT
<213> Homo sapiens

<400> 7653
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Glu Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Leu Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Met Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ala Gln Lys Leu Leu Arg Pro
        755                 760                 765             
Asn Ser Leu Arg Leu Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg
    770                 775                 780                 
Ala Ser Ser Pro Asn Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe
785                 790                 795                 800 
Gly Gly Ile Met Ser Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr
                805                 810                 815     
Ser Phe Ser Leu Ser Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu
            820                 825                 830         
Lys Ala Thr Pro Phe Pro Ser Leu Lys Gly Asn Arg Arg Ala Leu Val
        835                 840                 845             
Asp Gln Lys Ser Ser Val Ile Lys His Ser Pro Thr Val Lys Arg Glu
    850                 855                 860                 
Pro Pro Ser Pro Gln Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln
865                 870                 875                 880 
Phe Leu Lys Glu Val Val His Ser Val Leu Asp Gly Gln Gly Val Gly
                885                 890                 895     
Trp Leu Asn Met Lys Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu
            900                 905                 910         
Arg Val Phe Val Leu Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp
        915                 920                 925             
Asp Ala Arg Gln Asp Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val
    930                 935                 940                 
Tyr Lys Gly Met Leu Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu
945                 950                 955                 960 
Gln Ser Tyr Ala His Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly
                965                 970                 975     
Leu Leu Glu Ile Ala Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys
            980                 985                 990         
Arg Lys Arg Ser Pro Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp
        995                 1000                1005            
Pro Gly Leu Ala Gly Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg
    1010                1015                1020                
Val Pro Gln Leu Gly Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro
1025                1030                1035                1040
Lys Glu Leu Asp Thr Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser
                1045                1050                1055    
Ile Gly Pro Glu Val Ile Lys Pro Val Phe Asp Leu Gly Glu Thr Glu
            1060                1065                1070        
Glu Lys Lys Ser Gln Ile Ser Ala Asp Ser Gly Val Ser Leu Thr Ser
        1075                1080                1085            
Ser Ser Gln Arg Thr Asp Gln Asp Ser Val Ile Gly Val Ser Pro Ala
    1090                1095                1100                
Val Met Ile Arg Ser Ser Ser Gln Asp Ser Glu Val Ser Thr Val Val
1105                1110                1115                1120
Ser Asn Ser Ser Gly Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser Ser
                1125                1130                1135    
Asn Ala Gly Asp Gly Pro Gly Gly Glu Gly Ser Val His Leu Ala Ser
            1140                1145                1150        
Ser Arg Gly Thr Leu Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala Thr
        1155                1160                1165            
Ser Thr Ile Phe Gly Lys Ala His Ser Leu Lys Pro Ser Ile Lys Glu
    1170                1175                1180                
Lys Leu Ala Gly Ser Pro Ile Arg Thr Ser Glu Asp Val Ser Gln Arg
1185                1190                1195                1200
Val Tyr Leu Tyr Glu Gly Leu Leu Gly Lys Glu Arg Ser Thr Leu Trp
                1205                1210                1215    
Asp Gln Met Gln Phe Trp Glu Asp Ala Phe Leu Asp Ala Val Met Leu
            1220                1225                1230        
Glu Arg Glu Gly Met Gly Met Asp Gln Gly Pro Gln Glu Met Ile Asp
        1235                1240                1245            
Arg Tyr Leu Ser Leu Gly Glu His Asp Arg Lys Arg Leu Glu Asp Asp
    1250                1255                1260                
Glu Asp Arg Leu Leu Ala Thr Leu Leu His Asn Leu Ile Ser Tyr Met
1265                1270                1275                1280
Leu Leu Met Lys Val Asn Lys Asn Asp Ile Arg Lys Lys Val Arg Arg
                1285                1290                1295    
Leu Met Gly Lys Ser His Ile Gly Leu Val Tyr Ser Gln Gln Ile Asn
            1300                1305                1310        
Glu Val Leu Asp Gln Leu Ala Asn Leu Asn Gly Arg Asp Leu Ser Ile
        1315                1320                1325            
Trp Ser Ser Gly Ser Arg His Met Lys Lys Gln Thr Phe Val Val His
    1330                1335                1340                
Ala Gly Thr Asp Thr Asn Gly Asp Ile Phe Phe Met Glu Val Cys Asp
1345                1350                1355                1360
Asp Cys Val Val Leu Arg Ser Asn Ile Gly Thr Val Tyr Glu Arg Trp
                1365                1370                1375    
Trp Tyr Glu Lys Leu Ile Asn Met Thr Tyr Cys Pro Lys Thr Lys Val
            1380                1385                1390        
Leu Cys Leu Trp Arg Arg Asn Gly Ser Glu Thr Gln Leu Asn Lys Phe
        1395                1400                1405            
Tyr Thr Lys Lys Cys Arg Glu Leu Tyr Tyr Cys Val Lys Asp Ser Met
    1410                1415                1420                
Glu Arg Ala Ala Ala Arg Gln Gln Ser Ile Lys Pro Gly Pro Glu Leu
1425                1430                1435                1440
Gly Gly Glu Phe Pro Val Gln Asp Leu Lys Thr Gly Glu Gly Gly Leu
                1445                1450                1455    
Leu Gln Val Thr Leu Glu Gly Ile Asn Leu Lys Phe Met His Asn Gln
            1460                1465                1470        
Val Phe Ile Glu Leu Asn His Ile Lys Lys Cys Asn Thr Val Arg Gly
        1475                1480                1485            
Val Phe Val Leu Glu Glu Phe Val Pro Glu Ile Lys Glu Val Val Ser
    1490                1495                1500                
His Lys Tyr Lys Thr Pro Met Ala His Glu Ile Cys Tyr Ser Val Leu
1505                1510                1515                1520
Cys Leu Phe Ser Tyr Val Ala Ala Val His Ser Ser Glu Glu Asp Leu
                1525                1530                1535    
Arg Thr Pro Pro Arg Pro Val Ser Ser
            1540                1545


<210> 7654
<211> 1588
<212> PRT
<213> Homo sapiens

<400> 7654
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Glu Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Leu Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr
        755                 760                 765             
Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp
    770                 775                 780                 
Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val
785                 790                 795                 800 
Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu
                805                 810                 815     
Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn
            820                 825                 830         
Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser
        835                 840                 845             
Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser
    850                 855                 860                 
Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe
865                 870                 875                 880 
Pro Ser Leu Lys Gly Asn Arg Arg Ala Leu Val Asp Gln Lys Ser Ser
                885                 890                 895     
Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro Pro Ser Pro Gln
            900                 905                 910         
Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe Leu Lys Glu Val
        915                 920                 925             
Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp Leu Asn Met Lys
    930                 935                 940                 
Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg Val Phe Val Leu
945                 950                 955                 960 
Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp Ala Arg Gln Asp
                965                 970                 975     
Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr Lys Gly Met Leu
            980                 985                 990         
Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln Ser Tyr Ala His
        995                 1000                1005            
Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu Leu Glu Ile Ala
    1010                1015                1020                
Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg Lys Arg Ser Pro
1025                1030                1035                1040
Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp Pro Gly Leu Ala Gly
                1045                1050                1055    
Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val Pro Gln Leu Gly
            1060                1065                1070        
Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro Lys Glu Leu Asp Thr
        1075                1080                1085            
Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser Ile Gly Pro Glu Val
    1090                1095                1100                
Ile Lys Pro Val Phe Asp Leu Gly Glu Thr Glu Glu Lys Lys Ser Gln
1105                1110                1115                1120
Ile Ser Ala Asp Ser Gly Val Ser Leu Thr Ser Ser Ser Gln Arg Thr
                1125                1130                1135    
Asp Gln Asp Ser Val Ile Gly Val Ser Pro Ala Val Met Ile Arg Ser
            1140                1145                1150        
Ser Ser Gln Asp Ser Glu Val Ser Thr Val Val Ser Asn Ser Ser Gly
        1155                1160                1165            
Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser Ser Asn Ala Gly Asp Gly
    1170                1175                1180                
Pro Gly Gly Glu Gly Ser Val His Leu Ala Ser Ser Arg Gly Thr Leu
1185                1190                1195                1200
Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala Thr Ser Thr Ile Phe Gly
                1205                1210                1215    
Lys Ala His Ser Leu Lys Pro Ser Ile Lys Glu Lys Leu Ala Gly Ser
            1220                1225                1230        
Pro Ile Arg Thr Ser Glu Asp Val Ser Gln Arg Val Tyr Leu Tyr Glu
        1235                1240                1245            
Gly Leu Leu Gly Lys Glu Arg Ser Thr Leu Trp Asp Gln Met Gln Phe
    1250                1255                1260                
Trp Glu Asp Ala Phe Leu Asp Ala Val Met Leu Glu Arg Glu Gly Met
1265                1270                1275                1280
Gly Met Asp Gln Gly Pro Gln Glu Met Ile Asp Arg Tyr Leu Ser Leu
                1285                1290                1295    
Gly Glu His Asp Arg Lys Arg Leu Glu Asp Asp Glu Asp Arg Leu Leu
            1300                1305                1310        
Ala Thr Leu Leu His Asn Leu Ile Ser Tyr Met Leu Leu Met Lys Val
        1315                1320                1325            
Asn Lys Asn Asp Ile Arg Lys Lys Val Arg Arg Leu Met Gly Lys Ser
    1330                1335                1340                
His Ile Gly Leu Val Tyr Ser Gln Gln Ile Asn Glu Val Leu Asp Gln
1345                1350                1355                1360
Leu Ala Asn Leu Asn Gly Arg Asp Leu Ser Ile Trp Ser Ser Gly Ser
                1365                1370                1375    
Arg His Met Lys Lys Gln Thr Phe Val Val His Ala Gly Thr Asp Thr
            1380                1385                1390        
Asn Gly Asp Ile Phe Phe Met Glu Val Cys Asp Asp Cys Val Val Leu
        1395                1400                1405            
Arg Ser Asn Ile Gly Thr Val Tyr Glu Arg Trp Trp Tyr Glu Lys Leu
    1410                1415                1420                
Ile Asn Met Thr Tyr Cys Pro Lys Thr Lys Val Leu Cys Leu Trp Arg
1425                1430                1435                1440
Arg Asn Gly Ser Glu Thr Gln Leu Asn Lys Phe Tyr Thr Lys Lys Cys
                1445                1450                1455    
Arg Glu Leu Tyr Tyr Cys Val Lys Asp Ser Met Glu Arg Ala Ala Ala
            1460                1465                1470        
Arg Gln Gln Ser Ile Lys Pro Gly Pro Glu Leu Gly Gly Glu Phe Pro
        1475                1480                1485            
Val Gln Asp Leu Lys Thr Gly Glu Gly Gly Leu Leu Gln Val Thr Leu
    1490                1495                1500                
Glu Gly Ile Asn Leu Lys Phe Met His Asn Gln Val Phe Ile Glu Leu
1505                1510                1515                1520
Asn His Ile Lys Lys Cys Asn Thr Val Arg Gly Val Phe Val Leu Glu
                1525                1530                1535    
Glu Phe Val Pro Glu Ile Lys Glu Val Val Ser His Lys Tyr Lys Thr
            1540                1545                1550        
Pro Met Ala His Glu Ile Cys Tyr Ser Val Leu Cys Leu Phe Ser Tyr
        1555                1560                1565            
Val Ala Ala Val His Ser Ser Glu Glu Asp Leu Arg Thr Pro Pro Arg
    1570                1575                1580                
Pro Val Ser Ser
1585            


<210> 7655
<211> 1479
<212> PRT
<213> Homo sapiens

<400> 7655
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Gly Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Phe Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Leu Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Ala Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ala Gln Lys Leu Leu Arg Pro
        755                 760                 765             
Asn Ser Leu Arg Leu Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg
    770                 775                 780                 
Ala Ser Ser Pro Asn Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe
785                 790                 795                 800 
Gly Gly Ile Met Ser Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr
                805                 810                 815     
Ser Phe Ser Leu Ser Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu
            820                 825                 830         
Lys Ala Thr Pro Phe Pro Ser Leu Lys Gly Asn Arg Arg Ala Leu Val
        835                 840                 845             
Asp Gln Lys Ser Ser Val Ile Lys His Ser Pro Thr Val Lys Arg Glu
    850                 855                 860                 
Pro Pro Ser Pro Gln Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln
865                 870                 875                 880 
Phe Leu Lys Glu Val Val His Ser Val Leu Asp Gly Gln Gly Val Gly
                885                 890                 895     
Trp Leu Asn Met Lys Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu
            900                 905                 910         
Arg Val Phe Val Leu Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp
        915                 920                 925             
Asp Ala Arg Gln Asp Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val
    930                 935                 940                 
Tyr Lys Gly Met Leu Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu
945                 950                 955                 960 
Gln Ser Tyr Ala His Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly
                965                 970                 975     
Leu Leu Glu Ile Ala Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys
            980                 985                 990         
Arg Lys Arg Ser Pro Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp
        995                 1000                1005            
Pro Gly Leu Ala Gly Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg
    1010                1015                1020                
Val Pro Gln Leu Gly Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro
1025                1030                1035                1040
Lys Glu Leu Asp Thr Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser
                1045                1050                1055    
Ile Gly Pro Glu Val Ile Lys Pro Val Phe Asp Leu Gly Glu Thr Glu
            1060                1065                1070        
Glu Lys Lys Ser Gln Ile Ser Ala Asp Ser Gly Val Ser Leu Thr Ser
        1075                1080                1085            
Ser Ser Gln Arg Thr Asp Gln Asp Ser Val Ile Gly Val Ser Pro Ala
    1090                1095                1100                
Val Met Ile Arg Ser Ser Ser Gln Asp Ser Glu Val Ser Thr Val Val
1105                1110                1115                1120
Ser Asn Ser Ser Gly Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser Ser
                1125                1130                1135    
Asn Ala Gly Asp Gly Pro Gly Gly Glu Gly Ser Val His Leu Ala Ser
            1140                1145                1150        
Ser Arg Gly Thr Leu Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala Thr
        1155                1160                1165            
Ser Thr Ile Phe Gly Lys Ala His Ser Leu Lys Pro Cys Ile Lys Glu
    1170                1175                1180                
Lys Leu Ala Gly Ser Pro Ile Arg Thr Ser Glu Asp Val Ser Gln Arg
1185                1190                1195                1200
Val Tyr Leu Tyr Glu Gly Leu Leu Gly Lys Glu Arg Ser Thr Leu Trp
                1205                1210                1215    
Asp Gln Met Gln Phe Trp Glu Asp Ala Phe Leu Asp Ala Val Met Leu
            1220                1225                1230        
Glu Arg Glu Gly Met Gly Met Asp Gln Gly Pro Gln Glu Met Ile Asp
        1235                1240                1245            
Arg Tyr Leu Ser Leu Gly Glu His Asp Arg Lys Arg Leu Glu Asp Asp
    1250                1255                1260                
Glu Asp Arg Leu Leu Ala Thr Leu Leu His Asn Leu Ile Ser Tyr Met
1265                1270                1275                1280
Leu Leu Met Lys Val Asn Lys Asn Asp Ile Arg Lys Lys Val Arg Arg
                1285                1290                1295    
Leu Met Gly Lys Ser His Ile Gly Leu Val Tyr Ser Gln Gln Ile Asn
            1300                1305                1310        
Glu Val Leu Asp Gln Leu Ala Asn Leu Asn Gly Arg Asp Leu Ser Ile
        1315                1320                1325            
Trp Ser Ser Gly Ser Arg His Met Lys Lys Gln Thr Phe Val Val His
    1330                1335                1340                
Ala Gly Thr Asp Thr Asn Gly Asp Ile Phe Phe Met Glu Val Cys Asp
1345                1350                1355                1360
Asp Cys Val Val Leu Arg Ser Asn Ile Gly Thr Val Tyr Glu Arg Trp
                1365                1370                1375    
Trp Tyr Glu Lys Leu Ile Asn Met Thr Tyr Cys Pro Lys Thr Lys Val
            1380                1385                1390        
Leu Cys Leu Trp Arg Arg Asn Gly Ser Glu Thr Gln Leu Asn Lys Phe
        1395                1400                1405            
Tyr Thr Lys Lys Cys Arg Glu Leu Tyr Tyr Cys Val Lys Asp Ser Met
    1410                1415                1420                
Glu Arg Ala Ala Ala Arg Gln Gln Ser Ile Lys Pro Gly Pro Glu Leu
1425                1430                1435                1440
Gly Gly Glu Phe Pro Val Gln Asp Leu Lys Thr Gly Glu Gly Gly Leu
                1445                1450                1455    
Leu Gln Val Thr Leu Glu Gly Ile Asn Leu Lys Phe Met His Asn Gln
            1460                1465                1470        
Phe Leu Lys Leu Lys Lys Trp
        1475                


<210> 7656
<211> 1608
<212> PRT
<213> Homo sapiens

<400> 7656
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Gly Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Phe Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Leu Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Ala Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Val Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr
        755                 760                 765             
Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp
    770                 775                 780                 
Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val
785                 790                 795                 800 
Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu
                805                 810                 815     
Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn
            820                 825                 830         
Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser
        835                 840                 845             
Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser
    850                 855                 860                 
Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe
865                 870                 875                 880 
Pro Ser Leu Lys Val Phe Gly Leu Asn Thr Leu Met Glu Ile Val Thr
                885                 890                 895     
Glu Ala Gly Pro Gly Ser Gly Glu Gly Asn Arg Arg Ala Leu Val Asp
            900                 905                 910         
Gln Lys Ser Ser Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro
        915                 920                 925             
Pro Ser Pro Gln Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe
    930                 935                 940                 
Leu Lys Glu Val Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp
945                 950                 955                 960 
Leu Asn Met Lys Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg
                965                 970                 975     
Val Phe Val Leu Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp
            980                 985                 990         
Ala Arg Gln Asp Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr
        995                 1000                1005            
Lys Gly Met Leu Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln
    1010                1015                1020                
Ser Tyr Ala His Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu
1025                1030                1035                1040
Leu Glu Ile Ala Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg
                1045                1050                1055    
Lys Arg Ser Pro Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp Pro
            1060                1065                1070        
Gly Leu Ala Gly Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val
        1075                1080                1085            
Pro Gln Leu Gly Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro Lys
    1090                1095                1100                
Glu Leu Asp Thr Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser Ile
1105                1110                1115                1120
Gly Pro Glu Val Ile Lys Pro Val Phe Asp Leu Gly Glu Thr Glu Glu
                1125                1130                1135    
Lys Lys Ser Gln Ile Ser Ala Asp Ser Gly Val Ser Leu Thr Ser Ser
            1140                1145                1150        
Ser Gln Arg Thr Asp Gln Asp Ser Val Ile Gly Val Ser Pro Ala Val
        1155                1160                1165            
Met Ile Arg Ser Ser Ser Gln Asp Ser Glu Val Ser Thr Val Val Ser
    1170                1175                1180                
Asn Ser Ser Gly Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser Ser Asn
1185                1190                1195                1200
Ala Gly Asp Gly Pro Gly Gly Glu Gly Ser Val His Leu Ala Ser Ser
                1205                1210                1215    
Arg Gly Thr Leu Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala Thr Ser
            1220                1225                1230        
Thr Ile Phe Gly Lys Ala His Ser Leu Lys Pro Cys Ile Lys Glu Lys
        1235                1240                1245            
Leu Ala Gly Ser Pro Ile Arg Thr Ser Glu Asp Val Ser Gln Arg Val
    1250                1255                1260                
Tyr Leu Tyr Glu Gly Leu Leu Gly Lys Glu Arg Ser Thr Leu Trp Asp
1265                1270                1275                1280
Gln Met Gln Phe Trp Glu Asp Ala Phe Leu Asp Ala Val Met Leu Glu
                1285                1290                1295    
Arg Glu Gly Met Gly Met Asp Gln Gly Pro Gln Glu Met Ile Asp Arg
            1300                1305                1310        
Tyr Leu Ser Leu Gly Glu His Asp Arg Lys Arg Leu Glu Asp Asp Glu
        1315                1320                1325            
Asp Arg Leu Leu Ala Thr Leu Leu His Asn Leu Ile Ser Tyr Met Leu
    1330                1335                1340                
Leu Met Lys Val Asn Lys Asn Asp Ile Arg Lys Lys Val Arg Arg Leu
1345                1350                1355                1360
Met Gly Lys Ser His Ile Gly Leu Val Tyr Ser Gln Gln Ile Asn Glu
                1365                1370                1375    
Val Leu Asp Gln Leu Ala Asn Leu Asn Gly Arg Asp Leu Ser Ile Trp
            1380                1385                1390        
Ser Ser Gly Ser Arg His Met Lys Lys Gln Thr Phe Val Val His Ala
        1395                1400                1405            
Gly Thr Asp Thr Asn Gly Asp Ile Phe Phe Met Glu Val Cys Asp Asp
    1410                1415                1420                
Cys Val Val Leu Arg Ser Asn Ile Gly Thr Val Tyr Glu Arg Trp Trp
1425                1430                1435                1440
Tyr Glu Lys Leu Ile Asn Met Thr Tyr Cys Pro Lys Thr Lys Val Leu
                1445                1450                1455    
Cys Leu Trp Arg Arg Asn Gly Ser Glu Thr Gln Leu Asn Lys Phe Tyr
            1460                1465                1470        
Thr Lys Lys Cys Arg Glu Leu Tyr Tyr Cys Val Lys Asp Ser Met Glu
        1475                1480                1485            
Arg Ala Ala Ala Arg Gln Gln Ser Ile Lys Pro Gly Pro Glu Leu Gly
    1490                1495                1500                
Gly Glu Phe Pro Val Gln Asp Leu Lys Thr Gly Glu Gly Gly Leu Leu
1505                1510                1515                1520
Gln Val Thr Leu Glu Gly Ile Asn Leu Lys Phe Met His Asn Gln Val
                1525                1530                1535    
Phe Ile Glu Leu Asn His Ile Lys Lys Cys Asn Thr Val Arg Gly Val
            1540                1545                1550        
Phe Val Leu Glu Glu Phe Val Pro Glu Ile Lys Glu Val Val Ser His
        1555                1560                1565            
Lys Tyr Lys Thr Pro Met Ala His Glu Ile Cys Tyr Ser Val Leu Cys
    1570                1575                1580                
Leu Phe Ser Tyr Val Ala Ala Val His Ser Ser Glu Glu Asp Leu Arg
1585                1590                1595                1600
Thr Pro Pro Arg Pro Val Ser Ser
                1605            


<210> 7657
<211> 217
<212> PRT
<213> Homo sapiens

<400> 7657
Met Glu His Ala Pro Trp Ser Pro Gly Ala Ser Ser Arg Ala Arg Ala
 1               5                  10                  15      
Gly His Thr Met Asn Thr Ser Pro Gly Thr Val Gly Ser Asp Pro Val
            20                  25                  30          
Ile Leu Ala Thr Ala Gly Tyr Asp His Thr Val Arg Phe Trp Gln Ala
        35                  40                  45              
His Ser Gly Ile Cys Thr Arg Thr Val Gln His Gln Asp Ser Gln Val
    50                  55                  60                  
Asn Ala Leu Glu Val Thr Pro Asp Arg Ser Val Ile Ala Ala Ala Gly
65                  70                  75                  80  
Tyr Gln His Ile Arg Met Tyr Asp Leu Asn Ser Asn Asn Pro Asn Pro
                85                  90                  95      
Ile Ile Ser Tyr Asp Gly Val Asn Lys Asn Ile Ala Ser Val Gly Phe
            100                 105                 110         
His Glu Asp Gly Arg Trp Met Tyr Thr Gly Gly Glu Asp Cys Thr Ala
        115                 120                 125             
Arg Ile Trp Asp Leu Arg Ser Arg Asn Leu Gln Cys Gln Arg Ile Phe
    130                 135                 140                 
Gln Val Asn Ala Pro Ile Asn Cys Val Cys Leu His Pro Asn Gln Ala
145                 150                 155                 160 
Glu Leu Ile Val Gly Asp Gln Ser Gly Ala Ile His Ile Trp Asp Leu
                165                 170                 175     
Lys Thr Asp His Asn Glu Gln Leu Ile Pro Glu Pro Glu Val Ser Ile
            180                 185                 190         
Thr Ser Ala His Ile Asp Pro Asp Ala Ser Tyr Met Ala Ala Val Asn
        195                 200                 205             
Ser Thr Ala Pro Arg His Leu Leu Gly
    210                 215         


<210> 7658
<211> 456
<212> PRT
<213> Homo sapiens

<400> 7658
Met Lys Ile Glu Glu Val Lys Ser Thr Thr Lys Thr Gln Arg Ile Ala
 1               5                  10                  15      
Ser His Ser His Val Lys Gly Leu Gly Leu Asp Glu Ser Gly Leu Ala
            20                  25                  30          
Lys Gln Ala Ala Ser Gly Leu Val Gly Gln Glu Asn Ala Arg Glu Ala
        35                  40                  45              
Cys Gly Val Ile Val Glu Leu Ile Lys Ser Lys Lys Met Ala Gly Arg
    50                  55                  60                  
Ala Val Leu Leu Ala Gly Pro Pro Gly Thr Gly Lys Thr Ala Leu Ala
65                  70                  75                  80  
Leu Ala Ile Ala Gln Glu Leu Gly Ser Lys Val Pro Phe Cys Pro Met
                85                  90                  95      
Val Gly Ser Glu Val Tyr Ser Thr Glu Ile Lys Lys Thr Glu Val Leu
            100                 105                 110         
Met Glu Asn Phe Arg Arg Ala Ile Gly Leu Arg Ile Lys Glu Thr Lys
        115                 120                 125             
Glu Val Tyr Glu Gly Glu Val Thr Glu Leu Thr Pro Cys Glu Thr Glu
    130                 135                 140                 
Asn Pro Met Gly Gly Tyr Gly Lys Thr Ile Ser His Val Ile Ile Gly
145                 150                 155                 160 
Leu Lys Thr Ala Lys Gly Thr Lys Gln Leu Lys Leu Asp Pro Ser Ile
                165                 170                 175     
Phe Glu Ser Leu Gln Lys Glu Arg Val Glu Ala Gly Asp Val Ile Tyr
            180                 185                 190         
Ile Glu Ala Asn Ser Gly Ala Val Lys Arg Gln Gly Arg Cys Asp Thr
        195                 200                 205             
Tyr Ala Thr Glu Phe Asp Leu Glu Ala Glu Glu Tyr Val Pro Leu Pro
    210                 215                 220                 
Lys Gly Asp Val His Lys Lys Lys Glu Ile Ile Gln Asp Val Thr Leu
225                 230                 235                 240 
His Asp Leu Asp Val Ala Asn Ala Arg Pro Gln Gly Gly Gln Asp Ile
                245                 250                 255     
Leu Ser Met Met Gly Gln Leu Met Lys Pro Lys Lys Thr Glu Ile Thr
            260                 265                 270         
Asp Lys Leu Arg Gly Glu Ile Asn Lys Val Val Asn Lys Tyr Ile Asp
        275                 280                 285             
Gln Gly Ile Ala Glu Leu Val Pro Gly Val Leu Phe Val Asp Glu Val
    290                 295                 300                 
His Met Leu Asp Ile Glu Cys Phe Thr Tyr Leu His Arg Ala Leu Glu
305                 310                 315                 320 
Ser Ser Ile Ala Pro Ile Val Ile Phe Ala Ser Asn Arg Gly Asn Cys
                325                 330                 335     
Val Ile Arg Gly Thr Glu Asp Ile Thr Ser Pro His Gly Ile Pro Leu
            340                 345                 350         
Asp Leu Leu Asp Arg Val Met Ile Ile Arg Thr Met Leu Tyr Thr Pro
        355                 360                 365             
Gln Glu Met Lys Gln Ile Ile Lys Ile Arg Ala Gln Thr Glu Gly Ile
    370                 375                 380                 
Asn Ile Ser Glu Glu Ala Leu Asn His Leu Gly Glu Ile Gly Thr Lys
385                 390                 395                 400 
Thr Thr Leu Arg Tyr Ser Val Gln Leu Leu Thr Pro Ala Asn Leu Leu
                405                 410                 415     
Ala Lys Ile Asn Gly Lys Asp Ser Ile Glu Lys Glu His Val Glu Glu
            420                 425                 430         
Ile Ser Glu Leu Phe Tyr Asp Ala Lys Ser Ser Ala Lys Ile Leu Ala
        435                 440                 445             
Asp Gln Gln Asp Lys Tyr Met Lys
    450                 455     


<210> 7659
<211> 1058
<212> PRT
<213> Homo sapiens

<400> 7659
Val Glu Met Leu Ser Val Val Glu Asn Gly Leu Asp Pro Gln Ala Ala
 1               5                  10                  15      
Ile Pro Val Ile Lys Lys Lys Leu Val Gly Ser Val Lys Ala Leu Gln
            20                  25                  30          
Lys Gln Tyr Val Ser Leu Asp Thr Val Val Thr Ser Glu Asp Gly Asp
        35                  40                  45              
Ala Asn Thr Met Cys Ser Ala Leu Glu Ala Val Phe Ile His Gly Leu
    50                  55                  60                  
His Ala Lys His Ile Arg Ala Glu Ala Gly Gly Lys Arg Lys Lys Ser
65                  70                  75                  80  
Ala His Gln Lys Pro Leu Pro Gln Pro Val Phe Trp Pro Leu Leu Lys
                85                  90                  95      
Ala Val Thr His Lys His Ile Ile Ser Glu Leu Glu His Leu Thr Phe
            100                 105                 110         
Val Asn Thr Asp Val Gly Arg Cys Arg Ala Trp Leu Arg Leu Ala Leu
        115                 120                 125             
Asn Asp Gly Leu Met Glu Cys Tyr Leu Lys Leu Leu Leu Gln Glu Gln
    130                 135                 140                 
Ala Arg Leu His Glu Tyr Tyr Gln Pro Thr Ala Leu Leu Arg Asp Ala
145                 150                 155                 160 
Glu Glu Gly Glu Phe Leu Leu Ser Phe Leu Gln Gly Leu Thr Ser Leu
                165                 170                 175     
Ser Phe Glu Leu Ser Tyr Lys Ser Ala Ile Leu Asn Glu Trp Thr Leu
            180                 185                 190         
Thr Pro Leu Ala Leu Ser Gly Leu Cys Pro Leu Ser Glu Leu Asp Pro
        195                 200                 205             
Leu Ser Thr Ser Gly Ala Glu Leu Gln Arg Lys Glu Ser Leu Asp Ser
    210                 215                 220                 
Ile Ser His Ser Ser Gly Ser Glu Asp Ile Glu Val His His Ser Gly
225                 230                 235                 240 
His Lys Ile Arg Arg Asn Gln Lys Leu Thr Ala Ser Ser Leu Ser Leu
                245                 250                 255     
Asp Thr Ala Ser Ser Ser Gln Leu Ser Cys Ser Leu Asn Ser Asp Ser
            260                 265                 270         
Cys Leu Leu Gln Glu Asn Gly Ser Lys Ser Pro Asp His Cys Glu Glu
        275                 280                 285             
Pro Met Ser Cys Asp Ser Asp Leu Gly Thr Ala Asn Ala Glu Asp Ser
    290                 295                 300                 
Asp Arg Ser Leu Gln Glu Val Leu Leu Glu Phe Ser Lys Ala Gln Val
305                 310                 315                 320 
Asn Ser Val Pro Thr Asn Gly Leu Ser Gln Glu Thr Glu Ile Pro Thr
                325                 330                 335     
Pro Gln Ala Ser Leu Ser Leu His Gly Leu Asn Thr Ser Thr Tyr Leu
            340                 345                 350         
His Cys Glu Ala Pro Ala Glu Pro Leu Pro Ala Gln Ala Ala Ser Gly
        355                 360                 365             
Thr Gln Asp Gly Val His Val Gln Glu Pro Arg Pro Gln Ala Pro Ser
    370                 375                 380                 
Pro Leu Asp Leu Gln Gln Pro Val Glu Ser Thr Ser Gly Gln Gln Pro
385                 390                 395                 400 
Ser Ser Thr Val Ser Glu Thr Ala Arg Glu Val Gly Gln Gly Asn Gly
                405                 410                 415     
Leu Gln Lys Ala Gln Ala His Asp Gly Ala Gly Leu Lys Leu Val Val
            420                 425                 430         
Ser Ser Pro Thr Ser Pro Lys Asn Lys Ser Trp Ile Ser Glu Asp Asp
        435                 440                 445             
Phe Tyr Arg Pro Ser Arg Glu Gln Pro Leu Glu Ser Ala Ser Asp His
    450                 455                 460                 
Pro Ile Ala Ser Tyr Arg Gly Thr Pro Gly Ser Arg Pro Gly Leu His
465                 470                 475                 480 
Arg His Phe Ser Gln Glu Pro Arg Lys Asn Cys Ser Leu Gly Ala Leu
                485                 490                 495     
Asp Gln Ala Cys Val Pro Ser Pro Gly Arg Arg Gln Ala Gln Ala Ala
            500                 505                 510         
Pro Ser Gln Gly His Lys Ser Phe Arg Val Val His Arg Arg Gln Met
        515                 520                 525             
Gly Leu Ser Asn Pro Phe Arg Gly Leu Met Lys Leu Gly Thr Val Glu
    530                 535                 540                 
Arg Arg Gly Ala Met Gly Ile Trp Lys Glu Leu Phe Cys Glu Leu Ser
545                 550                 555                 560 
Pro Leu Glu Phe Arg Leu Tyr Leu Ser Asn Glu Glu His Thr Cys Val
                565                 570                 575     
Glu Asn Cys Ser Leu Leu Arg Cys Glu Ser Val Gly Pro Ala His Ser
            580                 585                 590         
Asp Gly Arg Phe Glu Leu Val Phe Ser Gly Lys Lys Leu Ala Leu Arg
        595                 600                 605             
Ala Ser Ser Gln Asp Glu Ala Glu Asp Trp Leu Asp Arg Val Arg Glu
    610                 615                 620                 
Ala Leu Gln Lys Val Arg Pro Gln Gln Glu Asp Glu Trp Val Asn Val
625                 630                 635                 640 
Gln Tyr Pro Asp Gln Pro Glu Glu Pro Pro Glu Ala Pro Gln Gly Cys
                645                 650                 655     
Leu Ser Pro Ser Asp Leu Leu Ser Glu Pro Ala Ala Leu Gln Gly Thr
            660                 665                 670         
Gln Phe Asp Trp Ser Ser Ala Gln Val Pro Glu Pro Asp Ala Ile Lys
        675                 680                 685             
Glu Ser Leu Leu Tyr Leu Tyr Met Asp Arg Thr Trp Met Pro Tyr Ile
    690                 695                 700                 
Phe Ser Leu Ser Leu Glu Ala Leu Lys Cys Phe Arg Ile Arg Asn Asn
705                 710                 715                 720 
Glu Lys Met Leu Ser Asp Ser His Gly Val Glu Thr Ile Arg Asp Ile
                725                 730                 735     
Leu Pro Asp Thr Ser Leu Gly Gly Pro Ser Phe Phe Lys Ile Ile Thr
            740                 745                 750         
Ala Lys Ala Val Leu Lys Leu Gln Ala Gly Asn Ala Glu Glu Ala Ala
        755                 760                 765             
Leu Trp Arg Asp Leu Val Arg Lys Val Leu Ala Ser Tyr Leu Glu Thr
    770                 775                 780                 
Ala Glu Glu Ala Val Thr Leu Gly Gly Ser Leu Asp Glu Asn Cys Gln
785                 790                 795                 800 
Glu Val Leu Lys Phe Ala Thr Arg Glu Asn Gly Phe Leu Leu Gln Tyr
                805                 810                 815     
Leu Val Ala Ile Pro Met Glu Lys Gly Leu Asp Ser Gln Gly Cys Phe
            820                 825                 830         
Cys Ala Gly Cys Ser Arg Gln Ile Gly Phe Ser Phe Val Arg Pro Lys
        835                 840                 845             
Leu Cys Ala Phe Ser Gly Leu Tyr Tyr Cys Asp Ile Cys His Gln Asp
    850                 855                 860                 
Asp Ala Ser Val Ile Pro Ala Arg Ile Ile His Asn Trp Asp Leu Thr
865                 870                 875                 880 
Lys Arg Pro Ile Cys Arg Gln Ala Leu Lys Phe Leu Thr Gln Ile Arg
                885                 890                 895     
Ala Gln Pro Leu Ile Asn Leu Gln Met Val Asn Ala Ser Leu Tyr Glu
            900                 905                 910         
His Val Glu Arg Met His Leu Ile Gly Arg Arg Arg Glu Gln Leu Lys
        915                 920                 925             
Leu Leu Gly Asp Tyr Leu Gly Leu Cys Arg Ser Gly Ala Leu Lys Glu
    930                 935                 940                 
Leu Ser Lys Arg Leu Asn His Arg Asn Tyr Leu Leu Glu Ser Pro His
945                 950                 955                 960 
Arg Phe Ser Val Ala Asp Leu Gln Gln Ile Ala Asp Gly Val Tyr Glu
                965                 970                 975     
Gly Phe Leu Lys Ala Leu Ile Glu Phe Ala Ser Gln His Val Tyr His
            980                 985                 990         
Cys Asp Leu Cys Thr Gln Arg Gly Phe Ile Cys Gln Ile Cys Gln His
        995                 1000                1005            
His Asp Ile Ile Phe Pro Phe Glu Phe Asp Thr Thr Val Arg Cys Ala
    1010                1015                1020                
Glu Cys Lys Thr Val Phe His Gln Ser Cys Gln Ala Val Val Lys Lys
1025                1030                1035                1040
Gly Cys Pro Arg Cys Ala Arg Arg Arg Lys Tyr Gln Glu Gln Asn Ile
                1045                1050                1055    
Phe Ala
        


<210> 7660
<211> 917
<212> PRT
<213> Homo sapiens

<400> 7660
Met Leu Ser Val Val Glu Asn Gly Leu Asp Pro Gln Ala Ala Ile Pro
 1               5                  10                  15      
Val Ile Lys Lys Lys Leu Val Gly Ser Val Lys Ala Leu Gln Lys Gln
            20                  25                  30          
Tyr Val Ser Leu Asp Met Val Val Thr Ser Glu Asp Gly Asp Ala Asn
        35                  40                  45              
Thr Met Cys Ser Ala Leu Glu Ala Val Phe Ile His Gly Leu His Thr
    50                  55                  60                  
Lys His Ile Arg Ala Glu Ala Gly Gly Lys Arg Lys Lys Ser Ala His
65                  70                  75                  80  
Gln Lys Pro Leu Pro Gln Pro Val Phe Trp Pro Leu Leu Lys Ala Val
                85                  90                  95      
Thr Pro Lys His Ile Ile Ser Glu Leu Glu His Leu Thr Phe Val Asn
            100                 105                 110         
Met Asp Val Gly Arg Cys Arg Ala Trp Leu Arg Leu Ala Leu Asn Asn
        115                 120                 125             
Gly Leu Met Glu Cys Tyr Leu Lys Leu Leu Leu Gln Glu Gln Ala Arg
    130                 135                 140                 
Leu Arg Glu Tyr Tyr Gln Pro Thr Ala Leu Leu Arg Asp Ala Glu Glu
145                 150                 155                 160 
Gly Glu Phe Leu Leu Ser Phe Leu Gln Gly Leu Met Ser Leu Ser Phe
                165                 170                 175     
Glu Leu Ser Tyr Lys Ser Ala Ile Leu Asn Glu Trp Thr Leu Thr Pro
            180                 185                 190         
Leu Ala Leu Ser Gly Leu Cys Pro Leu Ser Glu Leu Asp Pro Leu Ser
        195                 200                 205             
Thr Ser Gly Ala Glu Leu Gln Arg Lys Glu Ser Leu Asp Ser Ile Ser
    210                 215                 220                 
His Ser Ser Gly Ser Glu Asp Ile Glu Val His His Ser Gly His Lys
225                 230                 235                 240 
Ile Arg Arg Asn Gln Lys Pro Thr Ala Ser Ser Leu Ser Leu Asp Thr
                245                 250                 255     
Ala Ser Ser Ser Gln Leu Ser Cys Ser Leu Asn Ser Asp Ser Cys Leu
            260                 265                 270         
Leu Gln Glu Asn Gly Ser Lys Ser Pro Asp His Cys Glu Glu Pro Met
        275                 280                 285             
Ser Tyr Asp Ser Asp Leu Gly Thr Ala Asn Ala Glu Asp Ser Asp Gln
    290                 295                 300                 
Ser Leu Gln Glu Lys Asn Lys Ser Trp Ile Ser Glu Asp Asp Phe Tyr
305                 310                 315                 320 
Arg Pro Ser Arg Glu Gln Pro Leu Lys Ser Ala Ser Asp His Pro Ile
                325                 330                 335     
Ala Ser Tyr Arg Gly Thr Pro Glu Ser Arg Pro Gly Leu His Arg His
            340                 345                 350         
Phe Ser Gln Glu Pro Arg Lys Asn Cys Ser Leu Gly Ala Leu Asp Gln
        355                 360                 365             
Ala Cys Val Pro Ser Pro Gly Arg Arg Gln Ala Gln Ala Ala Pro Ser
    370                 375                 380                 
Gln Gly His Lys Ser Phe Gln Val Val His Arg Arg Gln Met Gly Leu
385                 390                 395                 400 
Ser Asn Pro Phe Gln Gly Leu Met Lys Leu Gly Thr Val Glu Arg Gln
                405                 410                 415     
Gly Ala Met Gly Ile Trp Lys Glu Leu Phe Cys Glu Leu Ser Pro Leu
            420                 425                 430         
Glu Phe Arg Leu Tyr Leu Ser Asn Glu Glu His Thr Cys Val Glu Asn
        435                 440                 445             
Cys Ser Leu Leu Arg Cys Glu Ser Val Gly Pro Ala His Ser Asp Gly
    450                 455                 460                 
Arg Phe Glu Leu Val Phe Ser Gly Lys Lys Leu Ala Leu Arg Ala Ser
465                 470                 475                 480 
Ser Gln Asp Glu Ala Glu Asp Trp Leu Asp Leu Val Arg Glu Ala Leu
                485                 490                 495     
Gln Lys Val Arg Pro Gln Gln Glu Asp Glu Trp Val Asn Val Gln Tyr
            500                 505                 510         
Ser Asp Gln Pro Glu Glu Pro Pro Glu Ala Pro Gln Gly Cys Leu Ser
        515                 520                 525             
Pro Ser Asp Leu Leu Ser Glu Pro Ala Ala Leu Gln Gly Thr Gln Ser
    530                 535                 540                 
Asp Trp Ser Ser Ala Gln Val Pro Glu Leu Asp Ala Ile Lys Glu Ser
545                 550                 555                 560 
Leu Leu Tyr Leu Tyr Met Asp Arg Thr Trp Met Pro Tyr Ile Phe Ser
                565                 570                 575     
Leu Pro Leu Glu Ala Leu Lys Cys Phe Arg Ile Arg Asn Asn Glu Lys
            580                 585                 590         
Met Leu Ser Asp Ser His Gly Val Glu Thr Ile Arg Asp Ile Leu Pro
        595                 600                 605             
Asp Thr Ser Leu Gly Gly Pro Ser Phe Phe Lys Ile Ile Thr Ala Lys
    610                 615                 620                 
Ala Val Leu Lys Leu Gln Ala Gly Asn Ala Glu Glu Ala Ala Leu Trp
625                 630                 635                 640 
Arg Asp Leu Val Arg Lys Val Leu Ala Ser Tyr Leu Glu Thr Ala Glu
                645                 650                 655     
Glu Ala Val Thr Leu Gly Gly Ser Leu Asp Glu Asn Cys Gln Glu Val
            660                 665                 670         
Leu Lys Phe Ala Thr Arg Glu Asn Gly Phe Leu Leu Gln Tyr Leu Val
        675                 680                 685             
Ala Ile Pro Met Glu Lys Gly Leu Asp Ser Gln Gly Cys Phe Cys Ala
    690                 695                 700                 
Gly Cys Ser Arg Gln Ile Gly Phe Ser Phe Val Arg Pro Lys Leu Cys
705                 710                 715                 720 
Ala Phe Ser Gly Leu Tyr Tyr Cys Asp Ile Cys His Gln Asp Asp Ala
                725                 730                 735     
Ser Val Ile Pro Ala Arg Ile Ile His Asn Trp Asp Leu Thr Lys Arg
            740                 745                 750         
Pro Ile Cys Arg Gln Ala Leu Lys Phe Leu Thr Gln Ile Arg Ala Gln
        755                 760                 765             
Pro Leu Ile Asn Leu Gln Met Val Asn Ala Ser Leu Tyr Glu His Val
    770                 775                 780                 
Glu Arg Met His Leu Ile Gly Arg Ser Arg Glu Gln Leu Lys Leu Leu
785                 790                 795                 800 
Gly Asp Tyr Leu Gly Leu Cys Arg Ser Gly Ala Leu Lys Glu Leu Ser
                805                 810                 815     
Lys Arg Leu Asn His Arg Asn Tyr Leu Leu Glu Ser Pro His Arg Phe
            820                 825                 830         
Arg Val Ala Asp Leu Arg Gln Ile Ala Asp Glu Val Tyr Glu Gly Phe
        835                 840                 845             
Leu Lys Ala Leu Ile Glu Phe Ala Ser Gln His Val Tyr His Cys Asp
    850                 855                 860                 
Leu Cys Thr Gln Arg Ser Phe Ile Cys Gln Ile Cys Gln His His Asp
865                 870                 875                 880 
Ile Ile Phe Pro Ser Glu Phe Asp Thr Thr Ile Arg Cys Ala Lys Cys
                885                 890                 895     
Lys Thr Val Phe His Gln Ser Cys Gln Ala Val Val Lys Lys Gly Cys
            900                 905                 910         
Pro Arg Cys Ala Arg
        915         


<210> 7661
<211> 427
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 264, 312
<223> Xaa = Any Amino Acid

<400> 7661
Met Ser Phe Thr Thr Arg Ser Thr Phe Ser Thr Asn Tyr Arg Ser Leu
 1               5                  10                  15      
Gly Ser Thr Gln Leu Leu Ser Tyr Gly Ala Gln Pro Ile Arg Thr Val
            20                  25                  30          
Ser Ser Val Tyr Ala Gly Ala Glu Ala Ser Gly Ser Arg Ile Ser Val
        35                  40                  45              
Ser Cys Ser Thr Ser Phe Arg Asp Gly Leu Gly Phe Ser Gly Leu Ala
    50                  55                  60                  
Met Gly Met Gly Gly Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Glu
65                  70                  75                  80  
Lys Lys Thr Met Gln Ser Leu Asn Asp Cys Leu Ala Ser Tyr Val Asp
                85                  90                  95      
Arg Val Arg Ser Met Glu Thr Lys Asn Trp Arg Leu Glu Asn Lys Ile
            100                 105                 110         
Trp Glu His Leu Glu Asn Asn Gly Pro Gln Val Arg Val Trp Asp His
        115                 120                 125             
Tyr Phe Lys Thr Ile Glu Asp Leu Arg Ala Gln Ile Phe Ala Asn Thr
    130                 135                 140                 
Val Asp Asn Ser Ser Ile Ala Leu Gln Thr Asp Asn Thr His Leu Ala
145                 150                 155                 160 
Ala Asp Asp Leu Arg Val Arg Tyr Glu Thr Glu Leu Ala Met Cys Gln
                165                 170                 175     
Ser Val Glu Ser Asn Ile Arg Gly Leu Cys Lys Val Ile Asp Asp Thr
            180                 185                 190         
Asn Val Thr Gln Leu Gln Leu Glu Thr Glu Ile Glu Ala Phe Lys Glu
        195                 200                 205             
Glu Leu Leu Phe Gly Lys Lys Asn His Glu Glu Glu Val Lys Ser Leu
    210                 215                 220                 
Gln Ala Gln Ile Ala Ser Ser Gly Leu Thr Val Glu Val Asp Ala Pro
225                 230                 235                 240 
Lys Ser Gln Asp Leu Ser Lys Ile Met Ala Asp Asn Gln Ala Gln Tyr
                245                 250                 255     
Asn Glu Leu Ser Arg Lys Asn Xaa Glu Glu Leu Asp Lys Tyr Trp Ser
            260                 265                 270         
Gln Gln Ile Glu Glu Ser Thr Thr Val Val Thr Val Gln Ser Ser Lys
        275                 280                 285             
Ile Arg Ala Ala Glu Met Thr Phe Thr Gly Leu Arg Cys Thr Val Gln
    290                 295                 300                 
Ser Leu Glu Ile Asp Leu Asp Xaa Met Arg Asn Leu Lys Ala Ser Leu
305                 310                 315                 320 
Lys Asn Ser Leu Arg Glu Val Glu Ala Arg Tyr Thr Met Gln Leu Asp
                325                 330                 335     
Lys Val Leu Met His Leu Gly Gly Gly Pro Ala Ala Ser Gln Ala Glu
            340                 345                 350         
Gly Gln His Gln Ala Gln Glu Tyr Glu Ala Leu Leu Asn Ile Lys Ile
        355                 360                 365             
Lys Leu Glu Ala Glu Ile Ala Thr Tyr His Gly Leu Leu Asp Asp Gly
    370                 375                 380                 
Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp Asn Ser Asn Ser Met Gln
385                 390                 395                 400 
Thr Ile Gln Lys Thr Thr Thr Arg Lys Ile Val Asp Ser Lys Val Val
                405                 410                 415     
Ser Glu Ile Asn Glu Thr Arg Val Leu Arg His
            420                 425         


<210> 7662
<211> 1873
<212> PRT
<213> Homo sapiens

<400> 7662
Met Glu Glu Gly Val Gln Ala Pro Asp Trp Asp Ser Asp Glu Thr Val
 1               5                  10                  15      
Ile Glu Gly Ser Val Thr Glu Ser Asp Leu Glu Glu Lys Glu Leu Pro
            20                  25                  30          
Trp Arg Arg Leu Leu Phe Asp Gln Asp Ala Ser Leu Lys Ser Glu Phe
        35                  40                  45              
Ser Leu His Pro Asp Thr Arg Gly Met Cys Lys Gly Met Pro Ser Pro
    50                  55                  60                  
Glu Ile Gln Leu Gly Phe Lys Leu Arg Glu Asp Leu Gln Glu Gln Met
65                  70                  75                  80  
Asn Lys Asn Lys Met Met Pro Val Leu Ser Glu Asp Thr Ile Leu Gln
                85                  90                  95      
Ser Gln Asp Glu Thr Glu Arg Asn Gln Ala Leu Leu Gln Thr Arg Lys
            100                 105                 110         
Asn Cys Ser Met Phe Ile Gly Ser Phe Arg Gln Ser Gly Leu Ser Leu
        115                 120                 125             
Asn His Gln Asn Ile Glu Gly Pro Glu Ala Glu Ser Pro Glu Val Leu
    130                 135                 140                 
Pro His Ile Glu Lys Glu Leu Ser Glu Gly Arg Asp Ser Pro Glu Val
145                 150                 155                 160 
Ser Leu Leu Ser Gly Thr Ala Ile Thr Val Ser Asp Thr Val Ala Val
                165                 170                 175     
Lys Glu Thr Ser Leu Val Glu Pro Glu Lys Ile Leu Ala Ala Pro Asn
            180                 185                 190         
Thr Phe Phe Glu Pro Arg Lys Glu Val Thr Met Thr Met Thr Ser Glu
        195                 200                 205             
Glu Thr Lys Asp Glu Glu Ser Ser Leu Glu Thr Phe Val Ser Ala Leu
    210                 215                 220                 
Glu Ser Leu Leu Thr Ser Pro Glu Ser Thr Gln Glu Glu Arg Leu Phe
225                 230                 235                 240 
Glu Leu Val Ser Asp Phe Asp Arg Lys Glu Leu Met Asn Pro Leu Ser
                245                 250                 255     
Asp Ser Leu Ser Ser Ile Ser Ile Pro Leu Asn Ser Trp Ser Ala Cys
            260                 265                 270         
His Arg Asp Leu Leu Glu Asp Ala Lys Asp Asp Ala Leu Pro Ala Glu
        275                 280                 285             
Leu Leu Glu Ala Leu Asn Thr Leu Ser Glu Ala Lys Val Glu Thr Ile
    290                 295                 300                 
Cys His Arg Lys Glu Gly Gly Ser Ser Leu Ile Ala Arg Asn Glu Cys
305                 310                 315                 320 
Leu Glu Val Glu Phe Asn Thr Ser Gln Thr Asn Glu Asp Cys Thr Gln
                325                 330                 335     
Ile Ala Glu Thr Leu Gln Asp Pro Asn Pro Ser Gly Leu Gln Thr Leu
            340                 345                 350         
Ala His Gln Asn Ile Thr Ser Cys Glu Pro Leu Ser Asn Lys Arg Asn
        355                 360                 365             
Ser Asn Ser Val Thr Asn Ser Ser Asp Gln Glu Thr Ala Cys Val Leu
    370                 375                 380                 
Arg Arg Ser Ser Arg Leu Glu Lys Leu Lys Val Ser Arg Asp Ala Lys
385                 390                 395                 400 
Tyr Ser Asp His Met Tyr Lys Met Pro Glu Lys Ile Leu Pro Lys Ile
                405                 410                 415     
Leu Gly Cys Glu Asp Leu Thr Asn Asn Asn Ser Ser Ala Gln Asn Phe
            420                 425                 430         
Arg Met Gln Asp Pro Ala Leu Met Ile Asp Gly Lys Glu Lys Asn Met
        435                 440                 445             
His Ser Ala Arg Phe Lys Asn Gly Lys Gln Ile Arg Lys Asn Glu Gln
    450                 455                 460                 
Phe Ser Gly Lys Lys Glu Lys Met Lys Val Asn Lys Ile Ser Leu His
465                 470                 475                 480 
Ser Ile Asn Arg Arg Asn Ile Phe Gly Glu Asn Leu Val Tyr Lys Ala
                485                 490                 495     
Ala Leu His Asp Asp Ala Asp Leu Val His His Cys Ile Lys Lys Gly
            500                 505                 510         
Gly Asn Val Asn Gln Pro Ser Tyr Ala Gly Trp Thr Ala Leu His Glu
        515                 520                 525             
Ala Ser Val Gly Gly Phe Tyr Arg Thr Ala Ser Glu Leu Leu Lys Gly
    530                 535                 540                 
Gly Ala Asp Val Asn Ile Lys Gly Leu Tyr Gln Ile Thr Pro Leu His
545                 550                 555                 560 
Asp Ala Val Met Asn Gly His Tyr Lys Val Ala Glu Leu Leu Leu Leu
                565                 570                 575     
Asn Gly Ala Asp Pro Leu Phe Arg Asn Asp Asp Gly Lys Cys Ala Leu
            580                 585                 590         
Asp Glu Ala Lys Asp Leu Cys Met Lys Arg Leu Leu Glu Arg Tyr Ile
        595                 600                 605             
Pro Lys His Gln Lys Cys Leu Thr Ser Ala Gln Arg Ser Ser Ile Asp
    610                 615                 620                 
Pro Leu Asp Ile Glu Asp Val Tyr Gln His Lys Lys Pro Lys Phe Ser
625                 630                 635                 640 
Ser Lys Ser His Ile Trp His Val Tyr Asn Glu Asn Ser Asn Arg Gln
                645                 650                 655     
Lys Leu Glu His Val Lys Val Asn Lys Gly Ser Lys Ala Ser Leu Phe
            660                 665                 670         
Ile Asn Lys Glu Asp Val Tyr Glu Tyr Tyr Gln Lys Asp Pro Lys Asn
        675                 680                 685             
Thr Lys Phe Gly Lys Ser Lys His Lys Gln Ser Thr Leu Asp Gln Ile
    690                 695                 700                 
Tyr Ser Thr Gly Leu Arg Lys Gly Asn Leu His Asn Val Lys Asp Pro
705                 710                 715                 720 
Asn Thr Asn Val Pro Lys Gly Ile Gly Arg Arg Lys Thr Gln His Lys
                725                 730                 735     
Arg Thr Gln Val Asp Asp Val Asp Cys Asn Pro Arg Lys Ile Leu Ala
            740                 745                 750         
Val Ser Pro Ser Arg Arg Ile Asn Arg Leu Val Thr Tyr Gln Gln His
        755                 760                 765             
Ile Pro Glu Thr His Asn Asp Leu Pro Glu Glu Leu Cys Glu Pro Ser
    770                 775                 780                 
Ser Leu Thr Leu Ser Ser Leu Arg Asn Gly Leu Asp Ser Ser Thr Glu
785                 790                 795                 800 
Ala Cys Ser Val Ser Lys Glu Lys His Ile Gln Asn Leu Asp Leu Ser
                805                 810                 815     
Asp Ser Gln Glu Val Gln Cys Leu Glu Leu Glu Ser Val Asp Gln Thr
            820                 825                 830         
Glu Ala Val Ser Phe Pro Gly Leu Leu Leu His Lys Glu Ile Lys Leu
        835                 840                 845             
Pro Val Val Thr Thr Asp Lys Gln Pro His Thr Leu Gln Glu Gln His
    850                 855                 860                 
His Val Leu Tyr Lys Ser His Glu Asn Ser Asn Leu Val Pro Lys Asp
865                 870                 875                 880 
Glu Arg Phe Asn Lys Trp Glu Asn Ser Phe Leu Ser Phe Val Lys Glu
                885                 890                 895     
Asn Ser Asp Asn Asp Asp Asp Asp Asp Cys Ser Thr Ser Glu Lys Ala
            900                 905                 910         
Ile Thr Ser Lys Lys Val Leu Cys Ser Thr Gly Gly Lys Lys His Tyr
        915                 920                 925             
Asn Phe Lys Glu Asn Leu Thr Asn Lys Lys Glu Met Gly Phe Gln Gln
    930                 935                 940                 
Phe Leu Leu Ser Glu Asp His Leu Ser Gln Glu Asn Glu Leu Lys Ala
945                 950                 955                 960 
Val Ser Leu Thr Thr Leu Pro Glu Gln Glu Ala Val Asn Phe Ser Tyr
                965                 970                 975     
Ser Asp Asn Ala Val Ile Ser Glu His Val Ala Asn Tyr Glu Gln Cys
            980                 985                 990         
Ile Phe Gly Pro Ser Phe Asp His Ser Asn Gly Asn Pro Glu Gln Asn
        995                 1000                1005            
Ser Leu Ala Cys Met Arg Thr Leu Leu Thr His Glu Ala Ser Lys Leu
    1010                1015                1020                
Thr Asn His Val Glu Leu Phe Lys Lys Pro Gln Asp Tyr Ile Pro Arg
1025                1030                1035                1040
Ala Pro Thr Phe Leu Met Asn Gln Thr Asp Thr His Ile Val Glu Lys
                1045                1050                1055    
Met Ala Lys Asn Cys Asp Thr Glu Arg Asn Tyr Ile Asp Arg Asp Gln
            1060                1065                1070        
Lys Ile Ile Tyr Ser Asn Glu Pro Leu Ser Ile Val Ala His Ser Gln
        1075                1080                1085            
Val Ile Glu Thr Thr Lys Val Glu Lys Arg Arg Gln Asn His Leu Glu
    1090                1095                1100                
Ser Glu Thr Ile His Asn Ile Asp Ser His Ser Thr Asp Asn Met Ser
1105                1110                1115                1120
Lys Glu Leu Ala Asn Ile Ser Lys Leu Ser Gln Arg Glu Lys Lys Glu
                1125                1130                1135    
Ile Ser His Lys Pro Gly Met Lys Ala Gly Arg Ile Asn Lys Arg Asn
            1140                1145                1150        
Ala Arg Gly Glu Ser Gln Leu His Leu Ala Val Arg Arg Gly Asn Leu
        1155                1160                1165            
Pro Leu Val Lys Ala Leu Ile Glu Ser Gly Ala Asp Val Asn Leu Asn
    1170                1175                1180                
Asp Asn Ala Gly Trp Thr Pro Leu His Glu Ala Ser Asn Glu Gly Ser
1185                1190                1195                1200
Ile Asp Ile Ile Val Glu Leu Leu Lys Ala Gly Ala Lys Val Asn Cys
                1205                1210                1215    
Glu Asn Ile Asp Gly Ile Leu Pro Leu His Asp Ala Val Ala Asn Asn
            1220                1225                1230        
His Leu Lys Ala Ala Glu Ile Leu Leu Gln Asn Gly Ala Asn Pro Asn
        1235                1240                1245            
Gln Lys Asp Gln Lys Gln Lys Ser Ala Leu Asp Glu Ala Asp Asp Glu
    1250                1255                1260                
Lys Met Lys Glu Leu Leu Arg Ser Tyr Gly Ala Ile Glu Thr Val Asn
1265                1270                1275                1280
Arg Asp Glu Ser Asp Ala Ile Val Asn Glu Lys Ile Pro Ala Val Arg
                1285                1290                1295    
Ser Lys Arg His Lys Gln Cys Phe Cys Asp Asp Gly Lys Thr Ile Asp
            1300                1305                1310        
Ser Ser Ser Leu Ser His Gln Glu Arg Ser Arg Glu Ser Leu Ser Val
        1315                1320                1325            
His Gln Thr Leu Ser Ala Ile Leu Gln Asp Ile Glu Glu Lys Gln Glu
    1330                1335                1340                
Tyr Leu Leu Glu Phe Glu Ile Arg Asn Pro Glu Asp Ala Glu Gln Tyr
1345                1350                1355                1360
Ile Glu Lys Met Leu Lys Ile Lys Lys Ile Met Asp Asn Val Leu Ala
                1365                1370                1375    
Lys Gln Lys Ala Glu Arg Asp Asp Leu Ala Lys Lys Tyr Arg Val Ser
            1380                1385                1390        
Ile Glu Ser Phe Lys His Gly Ala Leu Arg Glu Gln Leu Ala Asn Leu
        1395                1400                1405            
Ala Ala Arg Gln Lys Ser Leu Leu Val Val Ala Lys Lys Gln Lys Lys
    1410                1415                1420                
Ile Ser Leu Lys Ile Gln Asn Cys Arg Asn Val Thr Ser Leu Pro Cys
1425                1430                1435                1440
Leu Ser Leu Arg Lys Leu Pro Pro Arg Ser Glu Ile Ser Ser Glu Lys
                1445                1450                1455    
Asp Ser Gln Glu Leu Thr Ser Leu Glu Asn Leu Glu His Pro Gln Ser
            1460                1465                1470        
Gly Ser Leu Ser Pro Val Ser Gly Ser Met Gln Glu Thr Gln Leu Ser
        1475                1480                1485            
Leu Glu Thr Trp Asn Tyr Ser Gln Asn Thr Asn Ile Cys Leu Asn Ser
    1490                1495                1500                
Glu Ala Val Arg Arg Gly Glu Phe Ser Gly Asn Asp Met Asn Ser Lys
1505                1510                1515                1520
Gln Asn Gly Ser Asp Cys Thr Leu Asp Gly Phe Pro Lys Ser Arg His
                1525                1530                1535    
Ser Asp Gly Thr Glu Lys Asn Lys Leu Pro Ser Gln Pro Val Ala Phe
            1540                1545                1550        
Ile Gly Gln Thr Glu Tyr Ser Gln Lys Glu Asn Asp Leu Thr Glu Ala
        1555                1560                1565            
Thr Asp Lys Asp His Glu Phe Tyr Val Ser Ser Pro Val Ile Gly Lys
    1570                1575                1580                
Leu Asn Ile Ser Glu Thr Ala Ser Val Leu Ala Glu Asn Ala Ala His
1585                1590                1595                1600
Pro Ser Asn Ile Ile Cys Asp Gln Asp Leu Ser Asn Tyr Asp Pro Lys
                1605                1610                1615    
Arg Gly Asn Arg Lys Thr Ser Ser Gln Gln Ser Pro Thr Gly Ala Ser
            1620                1625                1630        
Glu Ser Leu Ala His Gln Gly Ile Ala Val Leu Gly Ser Asp Thr Val
        1635                1640                1645            
His Gln Met Lys Pro Tyr Leu Lys Lys Ser Val Ser Val Val Pro Cys
    1650                1655                1660                
Ala Asp Asp Ser Gln Ile Ser Ser Ser Ser Gly Ser Gly Gln Gln Asp
1665                1670                1675                1680
Thr Ile Lys Lys Ala Leu Asn Tyr Ser Thr Ala Pro Lys Lys Lys Cys
                1685                1690                1695    
Ile Gln Ile Lys Asp Leu Ile Leu Leu Gly Arg Ile Asn Pro Gly Asn
            1700                1705                1710        
Asn Ile Leu Glu Phe Lys Thr Gln Glu Thr Thr His Lys Ala Ser Ile
        1715                1720                1725            
Leu Leu Asn Gly Lys Leu Lys Val Glu Ser Gly Gln Ile Tyr Lys Asn
    1730                1735                1740                
Pro Val Thr Trp Leu Lys Asp Leu Leu Gly Gly Asn Ser Tyr Val Thr
1745                1750                1755                1760
Trp Asn Tyr Ala Trp Ser Lys Val Thr Tyr Leu Gly Lys Glu Leu Leu
                1765                1770                1775    
Arg Tyr Val Ser Glu Asp Ala Pro Ile Leu Pro Glu Pro Asn Ser Val
            1780                1785                1790        
Pro Gln Gln Tyr Gln Pro Cys Leu Pro Glu Val Ala Cys Leu Asp Asp
        1795                1800                1805            
Pro Val Gln Glu Pro Asn Lys Ser Met Phe Glu Lys Thr Lys Phe Gly
    1810                1815                1820                
Gln Gly Thr Ser Arg Glu Ser Met Gln Ser Ser Pro Arg Tyr Leu Gln
1825                1830                1835                1840
Ile Asn Glu Ile Leu Leu Ile Ser Asp Gln Glu Phe Leu Pro Cys His
                1845                1850                1855    
Ile Met Asp Gln His Trp Lys Phe Cys Val Glu Cys Glu Glu Leu Thr
            1860                1865                1870        
Pro
    


<210>  7663
<211>  27051
<212>  PRT
<213>  Homo sapiens

<400>  7663

Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro Pro Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Met Lys Glu Thr Arg 
545                 550                 555                 560 


Lys Thr Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu 
                565                 570                 575     


Gln Asp Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu 
            580                 585                 590         


Gln Val Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr 
        595                 600                 605             


Ala Leu Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu 
    610                 615                 620                 


Thr Ile Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile 
625                 630                 635                 640 


Gln Val Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val 
                645                 650                 655     


Ala Thr Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg 
            660                 665                 670         


Glu Pro Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu 
        675                 680                 685             


Tyr Gly Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro 
    690                 695                 700                 


Gln Arg Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro 
705                 710                 715                 720 


Arg Val Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln 
                725                 730                 735     


Lys Gly Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr 
            740                 745                 750         


Thr Glu Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro 
        755                 760                 765             


His Phe Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr 
    770                 775                 780                 


Glu Ala Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu 
785                 790                 795                 800 


Ser Ala Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro 
                805                 810                 815     


Thr Val Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu 
            820                 825                 830         


Pro Gln Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala 
        835                 840                 845             


Gly Val Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr 
    850                 855                 860                 


Val Arg Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val 
865                 870                 875                 880 


Thr Glu Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro 
                885                 890                 895     


Pro Thr Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu 
            900                 905                 910         


Ser Val Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val 
        915                 920                 925             


Thr Trp Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln 
    930                 935                 940                 


Ile Thr Phe Gln Ser Gly Ile Ala Arg Leu Met Ile Arg Glu Ala Phe 
945                 950                 955                 960 


Ala Glu Asp Ser Gly Arg Phe Thr Cys Ser Ala Val Asn Glu Ala Gly 
                965                 970                 975     


Thr Val Ser Thr Ser Cys Tyr Leu Ala Val Gln Val Ser Glu Glu Phe 
            980                 985                 990         


Glu Lys Glu Thr Thr Ala Val Thr  Glu Lys Phe Thr Thr  Glu Glu Lys 
        995                 1000                 1005             


Arg Phe  Val Glu Ser Arg Asp  Val Val Met Thr Asp  Thr Ser Leu 
    1010                 1015                 1020             


Thr Glu  Glu Gln Ala Gly Pro  Gly Glu Pro Ala Ala  Pro Tyr Phe 
    1025                 1030                 1035             


Ile Thr  Lys Pro Val Val Gln  Lys Leu Val Glu Gly  Gly Ser Val 
    1040                 1045                 1050             


Val Phe  Gly Cys Gln Val Gly  Gly Asn Pro Lys Pro  His Val Tyr 
    1055                 1060                 1065             


Trp Lys  Lys Ser Gly Val Pro  Leu Thr Thr Gly Tyr  Arg Tyr Lys 
    1070                 1075                 1080             


Val Ser  Tyr Asn Lys Gln Thr  Gly Glu Cys Lys Leu  Val Ile Ser 
    1085                 1090                 1095             


Met Thr  Phe Ala Asp Asp Ala  Gly Glu Tyr Thr Ile  Val Val Arg 
    1100                 1105                 1110             


Asn Lys  His Gly Glu Thr Ser  Ala Ser Ala Ser Leu  Leu Glu Glu 
    1115                 1120                 1125             


Ala Asp  Tyr Glu Leu Leu Met  Lys Ser Gln Gln Glu  Met Leu Tyr 
    1130                 1135                 1140             


Gln Thr  Gln Val Thr Ala Phe  Val Gln Glu Pro Lys  Val Gly Glu 
    1145                 1150                 1155             


Thr Ala  Pro Gly Phe Val Tyr  Ser Glu Tyr Glu Lys  Glu Tyr Glu 
    1160                 1165                 1170             


Lys Glu  Gln Ala Leu Ile Arg  Lys Lys Met Ala Lys  Asp Thr Val 
    1175                 1180                 1185             


Val Val  Arg Thr Tyr Val Glu  Asp Gln Glu Phe His  Ile Ser Ser 
    1190                 1195                 1200             


Phe Glu  Glu Arg Leu Ile Lys  Glu Ile Glu Tyr Arg  Ile Ile Lys 
    1205                 1210                 1215             


Thr Thr  Leu Glu Glu Leu Leu  Glu Glu Asp Gly Glu  Glu Lys Met 
    1220                 1225                 1230             


Ala Val  Asp Ile Ser Glu Ser  Glu Ala Val Glu Ser  Gly Phe Asp 
    1235                 1240                 1245             


Leu Arg  Ile Lys Asn Tyr Arg  Ile Leu Glu Gly Met  Gly Val Thr 
    1250                 1255                 1260             


Phe His  Cys Lys Met Ser Gly  Tyr Pro Leu Pro Lys  Ile Ala Trp 
    1265                 1270                 1275             


Tyr Lys  Asp Gly Lys Arg Ile  Lys His Gly Glu Arg  Tyr Gln Met 
    1280                 1285                 1290             


Asp Phe  Leu Gln Asp Gly Arg  Ala Ser Leu Arg Ile  Pro Val Val 
    1295                 1300                 1305             


Leu Pro  Glu Asp Glu Gly Ile  Tyr Thr Ala Phe Ala  Ser Asn Ile 
    1310                 1315                 1320             


Lys Gly  Asn Ala Ile Cys Ser  Gly Lys Leu Tyr Val  Glu Pro Ala 
    1325                 1330                 1335             


Ala Pro  Leu Gly Ala Pro Thr  Tyr Ile Pro Thr Leu  Glu Pro Val 
    1340                 1345                 1350             


Ser Arg  Ile Arg Ser Leu Ser  Pro Arg Ser Val Ser  Arg Ser Pro 
    1355                 1360                 1365             


Ile Arg  Met Ser Pro Ala Arg  Met Ser Pro Ala Arg  Met Ser Pro 
    1370                 1375                 1380             


Ala Arg  Met Ser Pro Ala Arg  Met Ser Pro Gly Arg  Arg Leu Glu 
    1385                 1390                 1395             


Glu Thr  Asp Glu Ser Gln Leu  Glu Arg Leu Tyr Lys  Pro Val Phe 
    1400                 1405                 1410             


Val Leu  Lys Pro Val Ser Phe  Lys Cys Leu Glu Gly  Gln Thr Ala 
    1415                 1420                 1425             


Arg Phe  Asp Leu Lys Val Val  Gly Arg Pro Met Pro  Glu Thr Phe 
    1430                 1435                 1440             


Trp Phe  His Asp Gly Gln Gln  Ile Val Asn Asp Tyr  Thr His Lys 
    1445                 1450                 1455             


Val Val  Ile Lys Glu Asp Gly  Thr Gln Ser Leu Ile  Ile Val Pro 
    1460                 1465                 1470             


Ala Thr  Pro Ser Asp Ser Gly  Glu Trp Thr Val Val  Ala Gln Asn 
    1475                 1480                 1485             


Arg Ala  Gly Arg Ser Ser Ile  Ser Val Ile Leu Thr  Val Glu Ala 
    1490                 1495                 1500             


Val Glu  His Gln Val Lys Pro  Met Phe Val Glu Lys  Leu Lys Asn 
    1505                 1510                 1515             


Val Asn  Ile Lys Glu Gly Ser  Arg Leu Glu Met Lys  Val Arg Ala 
    1520                 1525                 1530             


Thr Gly  Asn Pro Asn Pro Asp  Ile Val Trp Leu Lys  Asn Ser Asp 
    1535                 1540                 1545             


Ile Ile  Val Pro His Lys Tyr  Pro Lys Ile Arg Ile  Glu Gly Thr 
    1550                 1555                 1560             


Lys Gly  Glu Ala Ala Leu Lys  Ile Asp Ser Thr Val  Ser Gln Asp 
    1565                 1570                 1575             


Ser Ala  Trp Tyr Thr Ala Thr  Ala Ile Asn Lys Ala  Gly Arg Asp 
    1580                 1585                 1590             


Thr Thr  Arg Cys Lys Val Asn  Val Glu Val Glu Phe  Ala Glu Pro 
    1595                 1600                 1605             


Glu Pro  Glu Arg Lys Leu Ile  Ile Pro Arg Gly Thr  Tyr Arg Ala 
    1610                 1615                 1620             


Lys Glu  Ile Ala Ala Pro Glu  Leu Glu Pro Leu His  Leu Arg Tyr 
    1625                 1630                 1635             


Gly Gln  Glu Gln Trp Glu Glu  Gly Asp Leu Tyr Asp  Lys Glu Lys 
    1640                 1645                 1650             


Gln Gln  Lys Pro Phe Phe Lys  Lys Lys Leu Thr Ser  Leu Arg Leu 
    1655                 1660                 1665             


Lys Arg  Phe Gly Pro Ala His  Phe Glu Cys Arg Leu  Thr Pro Ile 
    1670                 1675                 1680             


Gly Asp  Pro Thr Met Val Val  Glu Trp Leu His Asp  Gly Lys Pro 
    1685                 1690                 1695             


Leu Glu  Ala Ala Asn Arg Leu  Arg Met Ile Asn Glu  Phe Gly Tyr 
    1700                 1705                 1710             


Cys Ser  Leu Asp Tyr Gly Val  Ala Tyr Ser Arg Asp  Ser Gly Ile 
    1715                 1720                 1725             


Ile Thr  Cys Arg Ala Thr Asn  Lys Tyr Gly Thr Asp  His Thr Ser 
    1730                 1735                 1740             


Ala Thr  Leu Ile Val Lys Asp  Glu Lys Ser Leu Val  Glu Glu Ser 
    1745                 1750                 1755             


Gln Leu  Pro Glu Gly Arg Lys  Gly Leu Gln Arg Ile  Glu Glu Leu 
    1760                 1765                 1770             


Glu Arg  Met Ala His Glu Gly  Ala Leu Thr Gly Val  Thr Thr Asp 
    1775                 1780                 1785             


Gln Lys  Glu Lys Gln Lys Pro  Asp Ile Val Leu Tyr  Pro Glu Pro 
    1790                 1795                 1800             


Val Arg  Val Leu Glu Gly Glu  Thr Ala Arg Phe Arg  Cys Arg Val 
    1805                 1810                 1815             


Thr Gly  Tyr Pro Gln Pro Lys  Val Asn Trp Tyr Leu  Asn Gly Gln 
    1820                 1825                 1830             


Leu Ile  Arg Lys Ser Lys Arg  Phe Arg Val Arg Tyr  Asp Gly Ile 
    1835                 1840                 1845             


His Tyr  Leu Asp Ile Val Asp  Cys Lys Ser Tyr Asp  Thr Gly Glu 
    1850                 1855                 1860             


Val Lys  Val Thr Ala Glu Asn  Pro Glu Gly Val Ile  Glu His Lys 
    1865                 1870                 1875             


Val Lys  Leu Glu Ile Gln Gln  Arg Glu Asp Phe Arg  Ser Val Leu 
    1880                 1885                 1890             


Arg Arg  Ala Pro Glu Pro Arg  Pro Glu Phe His Val  His Glu Pro 
    1895                 1900                 1905             


Gly Lys  Leu Gln Phe Glu Val  Gln Lys Val Asp Arg  Pro Val Asp 
    1910                 1915                 1920             


Thr Thr  Glu Thr Lys Glu Val  Val Lys Leu Lys Arg  Ala Glu Arg 
    1925                 1930                 1935             


Ile Thr  His Glu Lys Val Pro  Glu Glu Ser Glu Glu  Leu Arg Ser 
    1940                 1945                 1950             


Lys Phe  Lys Arg Arg Thr Glu  Glu Gly Tyr Tyr Glu  Ala Ile Thr 
    1955                 1960                 1965             


Ala Val  Glu Leu Lys Ser Arg  Lys Lys Asp Glu Ser  Tyr Glu Glu 
    1970                 1975                 1980             


Leu Leu  Arg Lys Thr Lys Asp  Glu Leu Leu His Trp  Thr Lys Glu 
    1985                 1990                 1995             


Leu Thr  Glu Glu Glu Lys Lys  Ala Leu Ala Glu Glu  Gly Lys Ile 
    2000                 2005                 2010             


Thr Ile  Pro Thr Phe Lys Pro  Asp Lys Ile Glu Leu  Ser Pro Ser 
    2015                 2020                 2025             


Met Glu  Ala Pro Lys Ile Phe  Glu Arg Ile Gln Ser  Gln Thr Val 
    2030                 2035                 2040             


Gly Gln  Gly Ser Asp Ala His  Phe Arg Val Arg Val  Val Gly Lys 
    2045                 2050                 2055             


Pro Asp  Pro Glu Cys Glu Trp  Tyr Lys Asn Gly Val  Lys Ile Glu 
    2060                 2065                 2070             


Arg Ser  Asp Arg Ile Tyr Trp  Tyr Trp Pro Glu Asp  Asn Val Cys 
    2075                 2080                 2085             


Glu Leu  Val Ile Arg Asp Val  Thr Ala Glu Asp Ser  Ala Ser Ile 
    2090                 2095                 2100             


Met Val  Lys Ala Ile Asn Ile  Ala Gly Glu Thr Ser  Ser His Ala 
    2105                 2110                 2115             


Phe Leu  Leu Val Gln Ala Lys  Gln Leu Ile Thr Phe  Thr Gln Glu 
    2120                 2125                 2130             


Leu Gln  Asp Val Val Ala Lys  Glu Lys Asp Thr Met  Ala Thr Phe 
    2135                 2140                 2145             


Glu Cys  Glu Thr Ser Glu Pro  Phe Val Lys Val Lys  Trp Tyr Lys 
    2150                 2155                 2160             


Asp Gly  Met Glu Val His Glu  Gly Asp Lys Tyr Arg  Met His Ser 
    2165                 2170                 2175             


Asp Arg  Lys Val His Phe Leu  Ser Ile Leu Thr Ile  Asp Thr Ser 
    2180                 2185                 2190             


Asp Ala  Glu Asp Tyr Ser Cys  Val Leu Val Glu Asp  Glu Asn Val 
    2195                 2200                 2205             


Lys Thr  Thr Ala Lys Leu Ile  Val Glu Gly Ala Val  Val Glu Phe 
    2210                 2215                 2220             


Val Lys  Glu Leu Gln Asp Ile  Glu Val Pro Glu Ser  Tyr Ser Gly 
    2225                 2230                 2235             


Glu Leu  Glu Cys Ile Val Ser  Pro Glu Asn Ile Glu  Gly Lys Trp 
    2240                 2245                 2250             


Tyr His  Asn Asp Val Glu Leu  Lys Ser Asn Gly Lys  Tyr Thr Ile 
    2255                 2260                 2265             


Thr Ser  Arg Arg Gly Arg Gln  Asn Leu Thr Val Lys  Asp Val Thr 
    2270                 2275                 2280             


Lys Glu  Asp Gln Gly Glu Tyr  Ser Phe Val Ile Asp  Gly Lys Lys 
    2285                 2290                 2295             


Thr Thr  Cys Lys Leu Lys Met  Lys Pro Arg Pro Ile  Ala Ile Leu 
    2300                 2305                 2310             


Gln Gly  Leu Ser Asp Gln Lys  Val Cys Glu Gly Asp  Ile Val Gln 
    2315                 2320                 2325             


Leu Glu  Val Lys Val Ser Leu  Glu Ser Val Glu Gly  Val Trp Met 
    2330                 2335                 2340             


Lys Asp  Gly Gln Glu Val Gln  Pro Ser Asp Arg Val  His Ile Val 
    2345                 2350                 2355             


Ile Asp  Lys Gln Ser His Met  Leu Leu Ile Glu Asp  Met Thr Lys 
    2360                 2365                 2370             


Glu Asp  Ala Gly Asn Tyr Ser  Phe Thr Ile Pro Ala  Leu Gly Leu 
    2375                 2380                 2385             


Ser Thr  Ser Gly Arg Val Ser  Val Tyr Ser Val Asp  Val Ile Thr 
    2390                 2395                 2400             


Pro Leu  Lys Asp Val Asn Val  Ile Glu Gly Thr Lys  Ala Val Leu 
    2405                 2410                 2415             


Glu Cys  Lys Val Ser Val Pro  Asp Val Thr Ser Val  Lys Trp Tyr 
    2420                 2425                 2430             


Leu Asn  Asp Glu Gln Ile Lys  Pro Asp Asp Arg Val  Gln Ala Ile 
    2435                 2440                 2445             


Val Lys  Gly Thr Lys Gln Arg  Leu Val Ile Asn Arg  Thr His Ala 
    2450                 2455                 2460             


Ser Asp  Glu Gly Pro Tyr Lys  Leu Ile Val Gly Arg  Val Glu Thr 
    2465                 2470                 2475             


Asn Cys  Asn Leu Ser Val Glu  Lys Ile Lys Ile Ile  Arg Gly Leu 
    2480                 2485                 2490             


Arg Asp  Leu Thr Cys Thr Glu  Thr Gln Asn Val Val  Phe Glu Val 
    2495                 2500                 2505             


Glu Leu  Ser His Ser Gly Ile  Asp Val Leu Trp Asn  Phe Lys Asp 
    2510                 2515                 2520             


Lys Glu  Ile Lys Pro Ser Ser  Lys Tyr Lys Ile Glu  Ala His Gly 
    2525                 2530                 2535             


Lys Ile  Tyr Lys Leu Thr Val  Leu Asn Met Met Lys  Asp Asp Glu 
    2540                 2545                 2550             


Gly Lys  Tyr Thr Phe Tyr Ala  Gly Glu Asn Ile Thr  Ser Gly Lys 
    2555                 2560                 2565             


Leu Thr  Val Ala Gly Gly Ala  Ile Ser Lys Pro Leu  Thr Asp Gln 
    2570                 2575                 2580             


Thr Val  Ala Glu Ser Gln Glu  Ala Val Phe Glu Cys  Glu Val Ala 
    2585                 2590                 2595             


Asn Pro  Asp Ser Lys Gly Glu  Trp Leu Arg Asp Gly  Lys His Leu 
    2600                 2605                 2610             


Pro Leu  Thr Asn Asn Ile Arg  Ser Glu Ser Asp Gly  His Lys Arg 
    2615                 2620                 2625             


Arg Leu  Ile Ile Ala Ala Thr  Lys Leu Asp Asp Ile  Gly Glu Tyr 
    2630                 2635                 2640             


Thr Tyr  Lys Val Ala Thr Ser  Lys Thr Ser Ala Lys  Leu Lys Val 
    2645                 2650                 2655             


Glu Ala  Val Lys Ile Lys Lys  Thr Leu Lys Asn Leu  Thr Val Thr 
    2660                 2665                 2670             


Glu Thr  Gln Asp Ala Val Phe  Thr Val Glu Leu Thr  His Pro Asn 
    2675                 2680                 2685             


Val Lys  Gly Val Gln Trp Ile  Lys Asn Gly Val Val  Leu Glu Ser 
    2690                 2695                 2700             


Asn Glu  Lys Tyr Ala Ile Ser  Val Lys Gly Thr Ile  Tyr Ser Leu 
    2705                 2710                 2715             


Arg Ile  Lys Asn Cys Ala Ile  Val Asp Glu Ser Val  Tyr Gly Phe 
    2720                 2725                 2730             


Arg Leu  Gly Arg Leu Gly Ala  Ser Ala Arg Leu His  Val Glu Thr 
    2735                 2740                 2745             


Val Lys  Ile Ile Lys Lys Pro  Lys Asp Val Thr Ala  Leu Glu Asn 
    2750                 2755                 2760             


Ala Thr  Val Ala Phe Glu Val  Ser Val Ser His Asp  Thr Val Pro 
    2765                 2770                 2775             


Val Lys  Trp Phe His Lys Ser  Val Glu Ile Lys Pro  Ser Asp Lys 
    2780                 2785                 2790             


His Arg  Leu Val Ser Glu Arg  Lys Val His Lys Leu  Met Leu Gln 
    2795                 2800                 2805             


Asn Ile  Ser Pro Ser Asp Ala  Gly Glu Tyr Thr Ala  Val Val Gly 
    2810                 2815                 2820             


Gln Leu  Glu Cys Lys Ala Lys  Leu Phe Val Glu Thr  Leu His Ile 
    2825                 2830                 2835             


Thr Lys  Thr Met Lys Asn Ile  Glu Val Pro Glu Thr  Lys Thr Ala 
    2840                 2845                 2850             


Ser Phe  Glu Cys Glu Val Ser  His Phe Asn Val Pro  Ser Met Trp 
    2855                 2860                 2865             


Leu Lys  Asn Gly Val Glu Ile  Glu Met Ser Glu Lys  Phe Lys Ile 
    2870                 2875                 2880             


Val Val  Gln Gly Lys Leu His  Gln Leu Ile Ile Met  Asn Thr Ser 
    2885                 2890                 2895             


Thr Glu  Asp Ser Ala Glu Tyr  Thr Phe Val Cys Gly  Asn Asp Gln 
    2900                 2905                 2910             


Val Ser  Ala Thr Leu Thr Val  Thr Pro Ile Met Ile  Thr Ser Met 
    2915                 2920                 2925             


Leu Lys  Asp Ile Asn Ala Glu  Glu Lys Asp Thr Ile  Thr Phe Glu 
    2930                 2935                 2940             


Val Thr  Val Asn Tyr Glu Gly  Ile Ser Tyr Lys Trp  Leu Lys Asn 
    2945                 2950                 2955             


Gly Val  Glu Ile Lys Ser Thr  Asp Lys Cys Gln Met  Arg Thr Lys 
    2960                 2965                 2970             


Lys Leu  Thr His Ser Leu Asn  Ile Arg Asn Val His  Phe Gly Asp 
    2975                 2980                 2985             


Ala Ala  Asp Tyr Thr Phe Val  Ala Gly Lys Ala Thr  Ser Thr Ala 
    2990                 2995                 3000             


Thr Leu  Tyr Val Glu Ala Arg  His Ile Glu Phe Arg  Lys His Ile 
    3005                 3010                 3015             


Lys Asp  Ile Lys Val Leu Glu  Lys Lys Arg Ala Met  Phe Glu Cys 
    3020                 3025                 3030             


Glu Val  Ser Glu Pro Asp Ile  Thr Val Gln Trp Met  Lys Asp Asp 
    3035                 3040                 3045             


Gln Glu  Leu Gln Ile Thr Asp  Arg Ile Lys Ile Gln  Lys Glu Lys 
    3050                 3055                 3060             


Tyr Val  His Arg Leu Leu Ile  Pro Ser Thr Arg Met  Ser Asp Ala 
    3065                 3070                 3075             


Gly Lys  Tyr Thr Val Val Ala  Gly Gly Asn Val Ser  Thr Ala Lys 
    3080                 3085                 3090             


Leu Phe  Val Glu Gly Arg Asp  Val Arg Ile Arg Ser  Ile Lys Lys 
    3095                 3100                 3105             


Glu Val  Gln Val Ile Glu Lys  Gln Arg Ala Val Val  Glu Phe Glu 
    3110                 3115                 3120             


Val Asn  Glu Asp Asp Val Asp  Ala His Trp Tyr Lys  Asp Gly Ile 
    3125                 3130                 3135             


Glu Ile  Asn Phe Gln Val Gln  Glu Arg His Lys Tyr  Val Val Glu 
    3140                 3145                 3150             


Arg Arg  Ile His Arg Met Phe  Ile Ser Glu Thr Arg  Gln Ser Asp 
    3155                 3160                 3165             


Ala Gly  Glu Tyr Thr Phe Val  Ala Gly Arg Asn Arg  Ser Ser Val 
    3170                 3175                 3180             


Thr Leu  Tyr Val Asn Ala Pro  Glu Pro Pro Gln Val  Leu Gln Glu 
    3185                 3190                 3195             


Leu Gln  Pro Val Thr Val Gln  Ser Gly Lys Pro Ala  Arg Phe Cys 
    3200                 3205                 3210             


Ala Val  Ile Ser Gly Arg Pro  Gln Pro Lys Ile Ser  Trp Tyr Lys 
    3215                 3220                 3225             


Glu Glu  Gln Leu Leu Ser Thr  Gly Phe Lys Cys Lys  Phe Leu His 
    3230                 3235                 3240             


Asp Gly  Gln Glu Tyr Thr Leu  Leu Leu Ile Glu Ala  Phe Pro Glu 
    3245                 3250                 3255             


Asp Ala  Ala Val Tyr Thr Cys  Glu Ala Lys Asn Asp  Tyr Gly Val 
    3260                 3265                 3270             


Ala Thr  Thr Ser Ala Ser Leu  Ser Val Glu Val Pro  Glu Val Val 
    3275                 3280                 3285             


Ser Pro  Asp Gln Glu Met Pro  Val Tyr Pro Pro Ala  Ile Ile Thr 
    3290                 3295                 3300             


Pro Leu  Gln Asp Thr Val Thr  Ser Glu Gly Gln Pro  Ala Arg Phe 
    3305                 3310                 3315             


Gln Cys  Arg Val Ser Gly Thr  Asp Leu Lys Val Ser  Trp Tyr Ser 
    3320                 3325                 3330             


Lys Asp  Lys Lys Ile Lys Pro  Ser Arg Phe Phe Arg  Met Thr Gln 
    3335                 3340                 3345             


Phe Glu  Asp Thr Tyr Gln Leu  Glu Ile Ala Glu Ala  Tyr Pro Glu 
    3350                 3355                 3360             


Asp Glu  Gly Thr Tyr Thr Phe  Val Ala Ser Asn Ala  Val Gly Gln 
    3365                 3370                 3375             


Val Ser  Ser Thr Ala Asn Leu  Ser Leu Glu Gly Phe  Ser Lys Phe 
    3380                 3385                 3390             


Glu Glu  Asn Thr Ser Asn Ser  Gln Trp His Val Ser  Leu Ser Val 
    3395                 3400                 3405             


Ser Phe  Lys Lys Glu Pro Leu  Gly Gln Lys Pro Ser  Phe Ile Gln 
    3410                 3415                 3420             


Pro Leu  Ser Ser Leu Arg Val  His Asn Gly Glu Thr  Val Arg Phe 
    3425                 3430                 3435             


His Ala  Arg Val Ser Gly Ile  Pro Lys Pro Glu Ile  Gln Trp Phe 
    3440                 3445                 3450             


His Asn  Gln Gln Leu Ile Leu  Pro Thr Lys Asp Val  Val Phe His 
    3455                 3460                 3465             


Phe Glu  Glu Ser Thr Gly Met  Ala Leu Met Leu Ile  Val Asp Ala 
    3470                 3475                 3480             


Tyr Ser  Glu His Ala Gly Gln  Tyr Ser Cys Lys Ala  Ala Asn Ser 
    3485                 3490                 3495             


Ala Gly  Glu Ala Thr Cys Ala  Ala Thr Leu Thr Val  Thr Pro Lys 
    3500                 3505                 3510             


Ala Pro  Glu Ser Ile Leu His  Glu Arg Ile Glu Gln  Glu Ile Glu 
    3515                 3520                 3525             


Met Glu  Met Lys Glu Phe Ser  Ser Ser Phe Leu Ser  Ala Glu Glu 
    3530                 3535                 3540             


Glu Gly  Leu His Ser Ala Glu  Leu Gln Leu Ser Lys  Ile Asn Glu 
    3545                 3550                 3555             


Thr Leu  Glu Leu Leu Ser Glu  Ser Pro Val Tyr Ser  Thr Lys Phe 
    3560                 3565                 3570             


Asp Ser  Glu Lys Glu Gly Thr  Gly Pro Ile Phe Ile  Lys Glu Val 
    3575                 3580                 3585             


Ser Asn  Ala Asp Ile Ser Met  Gly Asp Val Ala Thr  Leu Ser Val 
    3590                 3595                 3600             


Thr Val  Ile Gly Ile Pro Lys  Pro Lys Ile Gln Trp  Phe Phe Asn 
    3605                 3610                 3615             


Gly Val  Leu Leu Thr Pro Ser  Ala Asp Tyr Lys Phe  Val Phe Asp 
    3620                 3625                 3630             


Gly Asp  Asp His Ser Leu Ile  Ile Leu Phe Thr Lys  Leu Glu Asp 
    3635                 3640                 3645             


Glu Gly  Glu Tyr Thr Cys Met  Ala Ser Asn Asp Tyr  Gly Lys Thr 
    3650                 3655                 3660             


Ile Cys  Ser Ala Tyr Leu Lys  Ile Asn Ser Lys Gly  Glu Gly His 
    3665                 3670                 3675             


Lys Asp  Thr Glu Thr Glu Ser  Ala Val Ala Lys Ser  Leu Glu Lys 
    3680                 3685                 3690             


Leu Gly  Gly Pro Cys Pro Pro  His Phe Leu Lys Glu  Leu Lys Pro 
    3695                 3700                 3705             


Ile Arg  Cys Ala Gln Gly Leu  Pro Ala Ile Phe Glu  Tyr Thr Val 
    3710                 3715                 3720             


Val Gly  Glu Pro Ala Pro Thr  Val Thr Trp Phe Lys  Glu Asn Lys 
    3725                 3730                 3735             


Gln Leu  Cys Thr Ser Val Tyr  Tyr Thr Ile Ile His  Asn Pro Asn 
    3740                 3745                 3750             


Gly Ser  Gly Thr Phe Ile Val  Asn Asp Pro Gln Arg  Glu Asp Ser 
    3755                 3760                 3765             


Gly Leu  Tyr Ile Cys Lys Ala  Glu Asn Met Leu Gly  Glu Ser Thr 
    3770                 3775                 3780             


Cys Ala  Ala Glu Leu Leu Val  Leu Leu Glu Asp Thr  Asp Met Thr 
    3785                 3790                 3795             


Asp Thr  Pro Cys Lys Ala Lys  Ser Thr Pro Glu Ala  Pro Glu Asp 
    3800                 3805                 3810             


Phe Pro  Gln Thr Pro Leu Lys  Gly Pro Ala Val Glu  Ala Leu Asp 
    3815                 3820                 3825             


Ser Glu  Gln Glu Ile Ala Thr  Phe Val Lys Asp Thr  Ile Leu Lys 
    3830                 3835                 3840             


Ala Ala  Leu Ile Thr Glu Glu  Asn Gln Gln Leu Ser  Tyr Glu His 
    3845                 3850                 3855             


Ile Ala  Lys Ala Asn Glu Leu  Ser Ser Gln Leu Pro  Leu Gly Ala 
    3860                 3865                 3870             


Gln Glu  Leu Gln Ser Ile Leu  Glu Gln Asp Lys Leu  Thr Pro Glu 
    3875                 3880                 3885             


Ser Thr  Arg Glu Phe Leu Cys  Ile Asn Gly Ser Ile  His Phe Gln 
    3890                 3895                 3900             


Pro Leu  Lys Glu Pro Ser Pro  Asn Leu Gln Leu Gln  Ile Val Gln 
    3905                 3910                 3915             


Ser Gln  Lys Thr Phe Ser Lys  Glu Gly Ile Leu Met  Pro Glu Glu 
    3920                 3925                 3930             


Pro Glu  Thr Gln Ala Val Leu  Ser Asp Thr Glu Lys  Ile Phe Pro 
    3935                 3940                 3945             


Ser Ala  Met Ser Ile Glu Gln  Ile Asn Ser Leu Thr  Val Glu Pro 
    3950                 3955                 3960             


Leu Lys  Thr Leu Leu Ala Glu  Pro Glu Gly Asn Tyr  Pro Gln Ser 
    3965                 3970                 3975             


Ser Ile  Glu Pro Pro Met His  Ser Tyr Leu Thr Ser  Val Ala Glu 
    3980                 3985                 3990             


Glu Val  Leu Ser Pro Lys Glu  Lys Thr Val Ser Asp  Thr Asn Arg 
    3995                 4000                 4005             


Glu Gln  Arg Val Thr Leu Gln  Lys Gln Glu Ala Gln  Ser Ala Leu 
    4010                 4015                 4020             


Ile Leu  Ser Gln Ser Leu Ala  Glu Gly His Val Glu  Ser Leu Gln 
    4025                 4030                 4035             


Ser Pro  Asp Val Met Ile Ser  Gln Val Asn Tyr Glu  Pro Leu Val 
    4040                 4045                 4050             


Pro Ser  Glu His Ser Cys Thr  Glu Gly Gly Lys Ile  Leu Ile Glu 
    4055                 4060                 4065             


Ser Ala  Asn Pro Leu Glu Asn  Ala Gly Gln Asp Ser  Ala Val Arg 
    4070                 4075                 4080             


Ile Glu  Glu Gly Lys Ser Leu  Arg Phe Pro Leu Ala  Leu Glu Glu 
    4085                 4090                 4095             


Lys Gln  Val Leu Leu Lys Glu  Glu His Ser Asp Asn  Val Val Met 
    4100                 4105                 4110             


Pro Pro  Asp Gln Ile Ile Glu  Ser Lys Arg Glu Pro  Val Ala Ile 
    4115                 4120                 4125             


Lys Lys  Val Gln Glu Val Gln  Gly Arg Asp Leu Leu  Ser Lys Glu 
    4130                 4135                 4140             


Ser Leu  Leu Ser Gly Ile Pro  Glu Glu Gln Arg Leu  Asn Leu Lys 
    4145                 4150                 4155             


Ile Gln  Ile Cys Arg Ala Leu  Gln Ala Ala Val Ala  Ser Glu Gln 
    4160                 4165                 4170             


Pro Gly  Leu Phe Ser Glu Trp  Leu Arg Asn Ile Glu  Lys Val Glu 
    4175                 4180                 4185             


Val Glu  Ala Val Asn Ile Thr  Gln Glu Pro Arg His  Ile Met Cys 
    4190                 4195                 4200             


Met Tyr  Leu Val Thr Ser Ala  Lys Ser Val Thr Glu  Glu Val Thr 
    4205                 4210                 4215             


Ile Ile  Ile Glu Asp Val Asp  Pro Gln Met Ala Asn  Leu Lys Met 
    4220                 4225                 4230             


Glu Leu  Arg Asp Ala Leu Cys  Ala Ile Ile Tyr Glu  Glu Ile Asp 
    4235                 4240                 4245             


Ile Leu  Thr Ala Glu Gly Pro  Arg Ile Gln Gln Gly  Ala Lys Thr 
    4250                 4255                 4260             


Ser Leu  Gln Glu Glu Met Asp  Ser Phe Ser Gly Ser  Gln Lys Val 
    4265                 4270                 4275             


Glu Pro  Ile Thr Glu Pro Glu  Val Glu Ser Lys Tyr  Leu Ile Ser 
    4280                 4285                 4290             


Thr Glu  Glu Val Ser Tyr Phe  Asn Val Gln Ser Arg  Val Lys Tyr 
    4295                 4300                 4305             


Leu Asp  Ala Thr Pro Val Thr  Lys Gly Val Ala Ser  Ala Val Val 
    4310                 4315                 4320             


Ser Asp  Glu Lys Gln Asp Glu  Ser Leu Lys Pro Ser  Glu Glu Lys 
    4325                 4330                 4335             


Glu Glu  Ser Ser Ser Glu Ser  Gly Thr Glu Glu Val  Ala Thr Val 
    4340                 4345                 4350             


Lys Ile  Gln Glu Ala Glu Gly  Gly Leu Ile Lys Glu  Asp Gly Pro 
    4355                 4360                 4365             


Met Ile  His Thr Pro Leu Val  Asp Thr Val Ser Glu  Glu Gly Asp 
    4370                 4375                 4380             


Ile Val  His Leu Thr Thr Ser  Ile Thr Asn Ala Lys  Glu Val Asn 
    4385                 4390                 4395             


Trp Tyr  Phe Glu Asn Lys Leu  Val Pro Ser Asp Glu  Lys Phe Lys 
    4400                 4405                 4410             


Cys Leu  Gln Asp Gln Asn Thr  Tyr Thr Leu Val Ile  Asp Lys Val 
    4415                 4420                 4425             


Asn Thr  Glu Asp His Gln Gly  Glu Tyr Val Cys Glu  Ala Leu Asn 
    4430                 4435                 4440             


Asp Ser  Gly Lys Thr Ala Thr  Ser Ala Lys Leu Thr  Val Val Lys 
    4445                 4450                 4455             


Arg Ala  Ala Pro Val Ile Lys  Arg Lys Ile Glu Pro  Leu Glu Val 
    4460                 4465                 4470             


Ala Leu  Gly His Leu Ala Lys  Phe Thr Cys Glu Ile  Gln Ser Ala 
    4475                 4480                 4485             


Pro Asn  Val Arg Phe Gln Trp  Phe Lys Ala Gly Arg  Glu Ile Tyr 
    4490                 4495                 4500             


Glu Ser  Asp Lys Cys Ser Ile  Arg Ser Ser Lys Tyr  Ile Ser Ser 
    4505                 4510                 4515             


Leu Glu  Ile Leu Arg Thr Gln  Val Val Asp Cys Gly  Glu Tyr Thr 
    4520                 4525                 4530             


Cys Lys  Ala Ser Asn Glu Tyr  Gly Ser Val Ser Cys  Thr Ala Thr 
    4535                 4540                 4545             


Leu Thr  Val Thr Val Pro Gly  Gly Glu Lys Lys Val  Arg Lys Leu 
    4550                 4555                 4560             


Leu Pro  Glu Arg Lys Pro Glu  Pro Lys Glu Glu Val  Val Leu Lys 
    4565                 4570                 4575             


Ser Val  Leu Arg Lys Arg Pro  Glu Glu Glu Glu Pro  Lys Val Glu 
    4580                 4585                 4590             


Pro Lys  Lys Leu Glu Lys Val  Lys Lys Pro Ala Val  Pro Glu Pro 
    4595                 4600                 4605             


Pro Pro  Pro Lys Pro Val Glu  Glu Val Glu Val Pro  Thr Val Thr 
    4610                 4615                 4620             


Lys Arg  Glu Arg Lys Ile Pro  Glu Pro Thr Lys Val  Pro Glu Ile 
    4625                 4630                 4635             


Lys Pro  Ala Ile Pro Leu Pro  Ala Pro Glu Pro Lys  Pro Lys Pro 
    4640                 4645                 4650             


Glu Ala  Glu Val Lys Thr Ile  Lys Pro Pro Pro Val  Glu Pro Glu 
    4655                 4660                 4665             


Pro Thr  Pro Ile Ala Ala Pro  Val Thr Val Pro Val  Val Gly Lys 
    4670                 4675                 4680             


Lys Ala  Glu Ala Lys Ala Pro  Lys Glu Glu Ala Ala  Lys Pro Lys 
    4685                 4690                 4695             


Gly Pro  Ile Lys Gly Val Pro  Lys Lys Thr Pro Ser  Pro Ile Glu 
    4700                 4705                 4710             


Ala Glu  Arg Arg Lys Leu Arg  Pro Gly Ser Gly Gly  Glu Lys Pro 
    4715                 4720                 4725             


Pro Asp  Glu Ala Pro Phe Thr  Tyr Gln Leu Lys Ala  Val Pro Leu 
    4730                 4735                 4740             


Lys Phe  Val Lys Glu Ile Lys  Asp Ile Ile Leu Thr  Glu Ser Glu 
    4745                 4750                 4755             


Phe Val  Gly Ser Ser Ala Ile  Phe Glu Cys Leu Val  Ser Pro Ser 
    4760                 4765                 4770             


Thr Ala  Ile Thr Thr Trp Met  Lys Asp Gly Ser Asn  Ile Arg Glu 
    4775                 4780                 4785             


Ser Pro  Lys His Arg Phe Ile  Ala Asp Gly Lys Asp  Arg Lys Leu 
    4790                 4795                 4800             


His Ile  Ile Asp Val Gln Leu  Ser Asp Ala Gly Glu  Tyr Thr Cys 
    4805                 4810                 4815             


Val Leu  Arg Leu Gly Asn Lys  Glu Lys Thr Ser Thr  Ala Lys Leu 
    4820                 4825                 4830             


Val Val  Glu Glu Leu Pro Val  Arg Phe Val Lys Thr  Leu Glu Glu 
    4835                 4840                 4845             


Glu Val  Thr Val Val Lys Gly  Gln Pro Leu Tyr Leu  Ser Cys Glu 
    4850                 4855                 4860             


Leu Asn  Lys Glu Arg Asp Val  Val Trp Arg Lys Asp  Gly Lys Ile 
    4865                 4870                 4875             


Val Val  Glu Lys Pro Gly Arg  Ile Val Pro Gly Val  Ile Gly Leu 
    4880                 4885                 4890             


Met Arg  Ala Leu Thr Ile Asn  Asp Ala Asp Asp Thr  Asp Ala Gly 
    4895                 4900                 4905             


Thr Tyr  Thr Val Thr Val Glu  Asn Ala Asn Asn Leu  Glu Cys Ser 
    4910                 4915                 4920             


Ser Cys  Val Lys Val Val Glu  Val Ile Arg Asp Trp  Leu Val Lys 
    4925                 4930                 4935             


Pro Ile  Arg Asp Gln His Val  Lys Pro Lys Gly Thr  Ala Ile Phe 
    4940                 4945                 4950             


Ala Cys  Asp Ile Ala Lys Asp  Thr Pro Asn Ile Lys  Trp Phe Lys 
    4955                 4960                 4965             


Gly Tyr  Asp Glu Ile Pro Ala  Glu Pro Asn Asp Lys  Thr Glu Ile 
    4970                 4975                 4980             


Leu Arg  Asp Gly Asn His Leu  Tyr Leu Lys Ile Lys  Asn Ala Met 
    4985                 4990                 4995             


Pro Glu  Asp Ile Ala Glu Tyr  Ala Val Glu Ile Glu  Gly Lys Arg 
    5000                 5005                 5010             


Tyr Pro  Ala Lys Leu Thr Leu  Gly Glu Arg Glu Val  Glu Leu Leu 
    5015                 5020                 5025             


Lys Pro  Ile Glu Asp Val Thr  Ile Tyr Glu Lys Glu  Ser Ala Ser 
    5030                 5035                 5040             


Phe Asp  Ala Glu Ile Ser Glu  Ala Asp Ile Pro Gly  Gln Trp Lys 
    5045                 5050                 5055             


Leu Lys  Gly Glu Leu Leu Arg  Pro Ser Pro Thr Cys  Glu Ile Lys 
    5060                 5065                 5070             


Ala Glu  Gly Gly Lys Arg Phe  Leu Thr Leu His Lys  Val Lys Leu 
    5075                 5080                 5085             


Asp Gln  Ala Gly Glu Val Leu  Tyr Gln Ala Leu Asn  Ala Ile Thr 
    5090                 5095                 5100             


Thr Ala  Ile Leu Thr Val Lys  Glu Ile Glu Leu Asp  Phe Ala Val 
    5105                 5110                 5115             


Pro Leu  Lys Asp Val Thr Val  Pro Glu Arg Arg Gln  Ala Arg Phe 
    5120                 5125                 5130             


Glu Cys  Val Leu Thr Arg Glu  Ala Asn Val Ile Trp  Ser Lys Gly 
    5135                 5140                 5145             


Pro Asp  Ile Ile Lys Ser Ser  Asp Lys Phe Asp Ile  Ile Ala Asp 
    5150                 5155                 5160             


Gly Lys  Lys His Ile Leu Val  Ile Asn Asp Ser Gln  Phe Asp Asp 
    5165                 5170                 5175             


Glu Gly  Val Tyr Thr Ala Glu  Val Glu Gly Lys Lys  Thr Ser Ala 
    5180                 5185                 5190             


Arg Leu  Phe Val Thr Gly Ile  Arg Leu Lys Phe Met  Ser Pro Leu 
    5195                 5200                 5205             


Glu Asp  Gln Thr Val Lys Glu  Gly Glu Thr Ala Thr  Phe Val Cys 
    5210                 5215                 5220             


Glu Leu  Ser His Glu Lys Met  His Val Val Trp Phe  Lys Asn Asp 
    5225                 5230                 5235             


Ala Lys  Leu His Thr Ser Arg  Thr Val Leu Ile Ser  Ser Glu Gly 
    5240                 5245                 5250             


Lys Thr  His Lys Leu Glu Met  Lys Glu Val Thr Leu  Asp Asp Ile 
    5255                 5260                 5265             


Ser Gln  Ile Lys Ala Gln Val  Lys Glu Leu Ser Ser  Thr Ala Gln 
    5270                 5275                 5280             


Leu Lys  Val Leu Glu Ala Asp  Pro Tyr Phe Thr Val  Lys Leu His 
    5285                 5290                 5295             


Asp Lys  Thr Ala Val Glu Lys  Asp Glu Ile Thr Leu  Lys Cys Glu 
    5300                 5305                 5310             


Val Ser  Lys Asp Val Pro Val  Lys Trp Phe Lys Asp  Gly Glu Glu 
    5315                 5320                 5325             


Ile Val  Pro Ser Pro Lys Tyr  Ser Ile Lys Ala Asp  Gly Leu Arg 
    5330                 5335                 5340             


Arg Ile  Leu Lys Ile Lys Lys  Ala Asp Leu Lys Asp  Lys Gly Glu 
    5345                 5350                 5355             


Tyr Val  Cys Asp Cys Gly Thr  Asp Lys Thr Lys Ala  Asn Val Thr 
    5360                 5365                 5370             


Val Glu  Ala Arg Leu Ile Lys  Val Glu Lys Pro Leu  Tyr Gly Val 
    5375                 5380                 5385             


Glu Val  Phe Val Gly Glu Thr  Ala His Phe Glu Ile  Glu Leu Ser 
    5390                 5395                 5400             


Glu Pro  Asp Val His Gly Gln  Trp Lys Leu Lys Gly  Gln Pro Leu 
    5405                 5410                 5415             


Thr Ala  Ser Pro Asp Cys Glu  Ile Ile Glu Asp Gly  Lys Lys His 
    5420                 5425                 5430             


Ile Leu  Ile Leu His Asn Cys  Gln Leu Gly Met Thr  Gly Glu Val 
    5435                 5440                 5445             


Ser Phe  Gln Ala Ala Asn Ala  Lys Ser Ala Ala Asn  Leu Lys Val 
    5450                 5455                 5460             


Lys Glu  Leu Pro Leu Ile Phe  Ile Thr Pro Leu Ser  Asp Val Lys 
    5465                 5470                 5475             


Val Phe  Glu Lys Asp Glu Ala  Lys Phe Glu Cys Glu  Val Ser Arg 
    5480                 5485                 5490             


Glu Pro  Lys Thr Phe Arg Trp  Leu Lys Gly Thr Gln  Glu Ile Thr 
    5495                 5500                 5505             


Gly Asp  Asp Arg Phe Glu Leu  Ile Lys Asp Gly Thr  Lys His Ser 
    5510                 5515                 5520             


Met Val  Ile Lys Ser Ala Ala  Phe Glu Asp Glu Ala  Lys Tyr Met 
    5525                 5530                 5535             


Phe Glu  Ala Glu Asp Lys His  Thr Ser Gly Lys Leu  Ile Ile Glu 
    5540                 5545                 5550             


Gly Ile  Arg Leu Lys Phe Leu  Thr Pro Leu Lys Asp  Val Thr Ala 
    5555                 5560                 5565             


Lys Glu  Lys Glu Ser Ala Val  Phe Thr Val Glu Leu  Ser His Asp 
    5570                 5575                 5580             


Asn Ile  Arg Val Lys Trp Phe  Lys Asn Asp Gln Arg  Leu His Thr 
    5585                 5590                 5595             


Thr Arg  Ser Val Ser Met Gln  Asp Glu Gly Lys Thr  His Ser Ile 
    5600                 5605                 5610             


Thr Phe  Lys Asp Leu Ser Ile  Asp Asp Thr Ser Gln  Ile Arg Val 
    5615                 5620                 5625             


Glu Ala  Met Gly Met Ser Ser  Glu Ala Lys Leu Thr  Val Leu Glu 
    5630                 5635                 5640             


Gly Asp  Pro Tyr Phe Thr Gly  Lys Leu Gln Asp Tyr  Thr Gly Val 
    5645                 5650                 5655             


Glu Lys  Asp Glu Val Ile Leu  Gln Cys Glu Ile Ser  Lys Ala Asp 
    5660                 5665                 5670             


Ala Pro  Val Lys Trp Phe Lys  Asp Gly Lys Glu Ile  Lys Pro Ser 
    5675                 5680                 5685             


Lys Asn  Ala Val Ile Lys Ala  Asp Gly Lys Lys Arg  Met Leu Ile 
    5690                 5695                 5700             


Leu Lys  Lys Ala Leu Lys Ser  Asp Ile Gly Gln Tyr  Thr Cys Asp 
    5705                 5710                 5715             


Cys Gly  Thr Asp Lys Thr Ser  Gly Lys Leu Asp Ile  Glu Asp Arg 
    5720                 5725                 5730             


Glu Ile  Lys Leu Val Arg Pro  Leu His Ser Val Glu  Val Met Glu 
    5735                 5740                 5745             


Thr Glu  Thr Ala Arg Phe Glu  Thr Glu Ile Ser Glu  Asp Asp Ile 
    5750                 5755                 5760             


His Ala  Asn Trp Lys Leu Lys  Gly Glu Ala Leu Leu  Gln Thr Pro 
    5765                 5770                 5775             


Asp Cys  Glu Ile Lys Glu Glu  Gly Lys Ile His Ser  Leu Val Leu 
    5780                 5785                 5790             


His Asn  Cys Arg Leu Asp Gln  Thr Gly Gly Val Asp  Phe Gln Ala 
    5795                 5800                 5805             


Ala Asn  Val Lys Ser Ser Ala  His Leu Arg Val Lys  Pro Arg Val 
    5810                 5815                 5820             


Ile Gly  Leu Leu Arg Pro Leu  Lys Asp Val Thr Val  Thr Ala Gly 
    5825                 5830                 5835             


Glu Thr  Ala Thr Phe Asp Cys  Glu Leu Ser Tyr Glu  Asp Ile Pro 
    5840                 5845                 5850             


Val Glu  Trp Tyr Leu Lys Gly  Lys Lys Leu Glu Pro  Ser Asp Lys 
    5855                 5860                 5865             


Val Val  Pro Arg Ser Glu Gly  Lys Val His Thr Leu  Thr Leu Arg 
    5870                 5875                 5880             


Asp Val  Lys Leu Glu Asp Ala  Gly Glu Val Gln Leu  Thr Ala Lys 
    5885                 5890                 5895             


Asp Phe  Lys Thr His Ala Asn  Leu Phe Val Lys Glu  Pro Pro Val 
    5900                 5905                 5910             


Glu Phe  Thr Lys Pro Leu Glu  Asp Gln Thr Val Glu  Glu Gly Ala 
    5915                 5920                 5925             


Thr Ala  Val Leu Glu Cys Glu  Val Ser Arg Glu Asn  Ala Lys Val 
    5930                 5935                 5940             


Lys Trp  Phe Lys Asn Gly Thr  Glu Ile Leu Lys Ser  Lys Lys Tyr 
    5945                 5950                 5955             


Glu Ile  Val Ala Asp Gly Arg  Val Arg Lys Leu Val  Ile His Asp 
    5960                 5965                 5970             


Cys Thr  Pro Glu Asp Ile Lys  Thr Tyr Thr Cys Asp  Ala Lys Asp 
    5975                 5980                 5985             


Phe Lys  Thr Ser Cys Asn Leu  Asn Val Val Pro Pro  His Val Glu 
    5990                 5995                 6000             


Phe Leu  Arg Pro Leu Thr Asp  Leu Gln Val Arg Glu  Lys Glu Met 
    6005                 6010                 6015             


Ala Arg  Phe Glu Cys Glu Leu  Ser Arg Glu Asn Ala  Lys Val Lys 
    6020                 6025                 6030             


Trp Phe  Lys Asp Gly Ala Glu  Ile Lys Lys Gly Lys  Lys Tyr Asp 
    6035                 6040                 6045             


Ile Ile  Ser Lys Gly Ala Val  Arg Ile Leu Val Ile  Asn Lys Cys 
    6050                 6055                 6060             


Leu Leu  Asp Asp Glu Ala Glu  Tyr Ser Cys Glu Val  Arg Thr Ala 
    6065                 6070                 6075             


Arg Thr  Ser Gly Met Leu Thr  Val Leu Glu Glu Glu  Ala Val Phe 
    6080                 6085                 6090             


Thr Lys  Asn Leu Ala Asn Ile  Glu Val Ser Glu Thr  Asp Thr Ile 
    6095                 6100                 6105             


Lys Leu  Val Cys Glu Val Ser  Lys Pro Gly Ala Glu  Val Ile Trp 
    6110                 6115                 6120             


Tyr Lys  Gly Asp Glu Glu Ile  Ile Glu Thr Gly Arg  Tyr Glu Ile 
    6125                 6130                 6135             


Leu Thr  Glu Gly Arg Lys Arg  Ile Leu Val Ile Gln  Asn Ala His 
    6140                 6145                 6150             


Leu Glu  Asp Ala Gly Asn Tyr  Asn Cys Arg Leu Pro  Ser Ser Arg 
    6155                 6160                 6165             


Thr Asp  Gly Lys Val Lys Val  His Glu Leu Ala Ala  Glu Phe Ile 
    6170                 6175                 6180             


Ser Lys  Pro Gln Asn Leu Glu  Ile Leu Glu Gly Glu  Lys Ala Glu 
    6185                 6190                 6195             


Phe Val  Cys Ser Ile Ser Lys  Glu Ser Phe Pro Val  Gln Trp Lys 
    6200                 6205                 6210             


Arg Asp  Asp Lys Thr Leu Glu  Ser Gly Asp Lys Tyr  Asp Val Ile 
    6215                 6220                 6225             


Ala Asp  Gly Lys Lys Arg Val  Leu Val Val Lys Asp  Ala Thr Leu 
    6230                 6235                 6240             


Gln Asp  Met Gly Thr Tyr Val  Val Met Val Gly Ala  Ala Arg Ala 
    6245                 6250                 6255             


Ala Ala  His Leu Thr Val Ile  Glu Lys Leu Arg Ile  Val Val Pro 
    6260                 6265                 6270             


Leu Lys  Asp Thr Arg Val Lys  Glu Gln Gln Glu Val  Val Phe Asn 
    6275                 6280                 6285             


Cys Glu  Val Asn Thr Glu Gly  Ala Lys Ala Lys Trp  Phe Arg Asn 
    6290                 6295                 6300             


Glu Glu  Ala Ile Phe Asp Ser  Ser Lys Tyr Ile Ile  Leu Gln Lys 
    6305                 6310                 6315             


Asp Leu  Val Tyr Thr Leu Arg  Ile Arg Asp Ala His  Leu Asp Asp 
    6320                 6325                 6330             


Gln Ala  Asn Tyr Asn Val Ser  Leu Thr Asn His Arg  Gly Glu Asn 
    6335                 6340                 6345             


Val Lys  Ser Ala Ala Asn Leu  Ile Val Glu Glu Glu  Asp Leu Arg 
    6350                 6355                 6360             


Ile Val  Glu Pro Leu Lys Asp  Ile Glu Thr Met Glu  Lys Lys Ser 
    6365                 6370                 6375             


Val Thr  Phe Trp Cys Lys Val  Asn Arg Leu Asn Val  Thr Leu Lys 
    6380                 6385                 6390             


Trp Thr  Lys Asn Gly Glu Glu  Val Pro Phe Asp Asn  Arg Val Ser 
    6395                 6400                 6405             


Tyr Arg  Val Asp Lys Tyr Lys  His Met Leu Thr Ile  Lys Asp Cys 
    6410                 6415                 6420             


Gly Phe  Pro Asp Glu Gly Glu  Tyr Ile Val Thr Ala  Gly Gln Asp 
    6425                 6430                 6435             


Lys Ser  Val Ala Glu Leu Leu  Ile Ile Glu Ala Pro  Thr Glu Phe 
    6440                 6445                 6450             


Val Glu  His Leu Glu Asp Gln  Thr Val Thr Glu Phe  Asp Asp Ala 
    6455                 6460                 6465             


Val Phe  Ser Cys Gln Leu Ser  Arg Glu Lys Ala Asn  Val Lys Trp 
    6470                 6475                 6480             


Tyr Arg  Asn Gly Arg Glu Ile  Lys Glu Gly Lys Lys  Tyr Lys Phe 
    6485                 6490                 6495             


Glu Lys  Asp Gly Ser Ile His  Arg Leu Ile Ile Lys  Asp Cys Arg 
    6500                 6505                 6510             


Leu Asp  Asp Glu Cys Glu Tyr  Ala Cys Gly Val Glu  Asp Arg Lys 
    6515                 6520                 6525             


Ser Arg  Ala Arg Leu Phe Val  Glu Glu Ile Pro Val  Glu Ile Ile 
    6530                 6535                 6540             


Arg Pro  Pro Gln Asp Ile Leu  Glu Ala Pro Gly Ala  Asp Val Val 
    6545                 6550                 6555             


Phe Leu  Ala Glu Leu Asn Lys  Asp Lys Val Glu Val  Gln Trp Leu 
    6560                 6565                 6570             


Arg Asn  Asn Met Val Val Val  Gln Gly Asp Lys His  Gln Met Met 
    6575                 6580                 6585             


Ser Glu  Gly Lys Ile His Arg  Leu Gln Ile Cys Asp  Ile Lys Pro 
    6590                 6595                 6600             


Arg Asp  Gln Gly Glu Tyr Arg  Phe Ile Ala Lys Asp  Lys Glu Ala 
    6605                 6610                 6615             


Arg Ala  Lys Leu Glu Leu Ala  Ala Ala Pro Lys Ile  Lys Thr Ala 
    6620                 6625                 6630             


Asp Gln  Asp Leu Val Val Asp  Val Gly Lys Pro Leu  Thr Met Val 
    6635                 6640                 6645             


Val Pro  Tyr Asp Ala Tyr Pro  Lys Ala Glu Ala Glu  Trp Phe Lys 
    6650                 6655                 6660             


Glu Asn  Glu Pro Leu Ser Thr  Lys Thr Ile Asp Thr  Thr Ala Glu 
    6665                 6670                 6675             


Gln Thr  Ser Phe Arg Ile Leu  Glu Ala Lys Lys Gly  Asp Lys Gly 
    6680                 6685                 6690             


Arg Tyr  Lys Ile Val Leu Gln  Asn Lys His Gly Lys  Ala Glu Gly 
    6695                 6700                 6705             


Phe Ile  Asn Leu Lys Val Ile  Asp Val Pro Gly Pro  Val Arg Asn 
    6710                 6715                 6720             


Leu Glu  Val Thr Glu Thr Phe  Asp Gly Glu Val Ser  Leu Ala Trp 
    6725                 6730                 6735             


Glu Glu  Pro Leu Thr Asp Gly  Gly Ser Lys Ile Ile  Gly Tyr Val 
    6740                 6745                 6750             


Val Glu  Arg Arg Asp Ile Lys  Arg Lys Thr Trp Val  Leu Ala Thr 
    6755                 6760                 6765             


Asp Arg  Ala Glu Ser Cys Glu  Phe Thr Val Thr Gly  Leu Gln Lys 
    6770                 6775                 6780             


Gly Gly  Val Glu Tyr Leu Phe  Arg Val Ser Ala Arg  Asn Arg Val 
    6785                 6790                 6795             


Gly Thr  Gly Glu Pro Val Glu  Thr Asp Asn Pro Val  Glu Ala Arg 
    6800                 6805                 6810             


Ser Lys  Tyr Asp Val Pro Gly  Pro Pro Leu Asn Val  Thr Ile Thr 
    6815                 6820                 6825             


Asp Val  Asn Arg Phe Gly Val  Ser Leu Thr Trp Glu  Pro Pro Glu 
    6830                 6835                 6840             


Tyr Asp  Gly Gly Ala Glu Ile  Thr Asn Tyr Val Ile  Glu Leu Arg 
    6845                 6850                 6855             


Asp Lys  Thr Ser Ile Arg Trp  Asp Thr Ala Met Thr  Val Arg Ala 
    6860                 6865                 6870             


Glu Asp  Leu Ser Ala Thr Val  Thr Asp Val Val Glu  Gly Gln Glu 
    6875                 6880                 6885             


Tyr Ser  Phe Arg Val Arg Ala  Gln Asn Arg Ile Gly  Val Gly Lys 
    6890                 6895                 6900             


Pro Ser  Ala Ala Thr Pro Phe  Val Lys Val Ala Asp  Pro Ile Glu 
    6905                 6910                 6915             


Arg Pro  Ser Pro Pro Val Asn  Leu Thr Ser Ser Asp  Gln Thr Gln 
    6920                 6925                 6930             


Ser Ser  Val Gln Leu Lys Trp  Glu Pro Pro Leu Lys  Asp Gly Gly 
    6935                 6940                 6945             


Ser Pro  Ile Leu Gly Tyr Ile  Ile Glu Arg Cys Glu  Glu Gly Lys 
    6950                 6955                 6960             


Asp Asn  Trp Ile Arg Cys Asn  Met Lys Leu Val Pro  Glu Leu Thr 
    6965                 6970                 6975             


Tyr Lys  Val Thr Gly Leu Glu  Lys Gly Asn Lys Tyr  Leu Tyr Arg 
    6980                 6985                 6990             


Val Ser  Ala Glu Asn Lys Ala  Gly Val Ser Asp Pro  Ser Glu Ile 
    6995                 7000                 7005             


Leu Gly  Pro Leu Thr Ala Asp  Asp Ala Phe Val Glu  Pro Thr Met 
    7010                 7015                 7020             


Asp Leu  Ser Ala Phe Lys Asp  Gly Leu Glu Val Ile  Val Pro Asn 
    7025                 7030                 7035             


Pro Ile  Thr Ile Leu Val Pro  Ser Thr Gly Tyr Pro  Arg Pro Thr 
    7040                 7045                 7050             


Ala Thr  Trp Cys Phe Gly Asp  Lys Val Leu Glu Thr  Gly Asp Arg 
    7055                 7060                 7065             


Val Lys  Met Lys Thr Leu Ser  Ala Tyr Ala Glu Leu  Val Ile Ser 
    7070                 7075                 7080             


Pro Ser  Glu Arg Ser Asp Lys  Gly Ile Tyr Thr Leu  Lys Leu Glu 
    7085                 7090                 7095             


Asn Arg  Val Lys Thr Ile Ser  Gly Glu Ile Asp Val  Asn Val Ile 
    7100                 7105                 7110             


Ala Arg  Pro Ser Ala Pro Lys  Glu Leu Lys Phe Gly  Asp Ile Thr 
    7115                 7120                 7125             


Lys Asp  Ser Val His Leu Thr  Trp Glu Pro Pro Asp  Asp Asp Gly 
    7130                 7135                 7140             


Gly Ser  Pro Leu Thr Gly Tyr  Val Val Glu Lys Arg  Glu Val Ser 
    7145                 7150                 7155             


Arg Lys  Thr Trp Thr Lys Val  Met Asp Phe Val Thr  Asp Leu Glu 
    7160                 7165                 7170             


Phe Thr  Val Pro Asp Leu Val  Gln Gly Lys Glu Tyr  Leu Phe Lys 
    7175                 7180                 7185             


Val Cys  Ala Arg Asn Lys Cys  Gly Pro Gly Glu Pro  Ala Tyr Val 
    7190                 7195                 7200             


Asp Glu  Pro Val Asn Met Ser  Thr Pro Ala Thr Val  Pro Asp Pro 
    7205                 7210                 7215             


Pro Glu  Asn Val Lys Trp Arg  Asp Arg Thr Ala Asn  Ser Ile Phe 
    7220                 7225                 7230             


Leu Thr  Trp Asp Pro Pro Lys  Asn Asp Gly Gly Ser  Arg Ile Lys 
    7235                 7240                 7245             


Gly Tyr  Ile Val Glu Arg Cys  Pro Arg Gly Ser Asp  Lys Trp Val 
    7250                 7255                 7260             


Ala Cys  Gly Glu Pro Val Ala  Glu Thr Lys Met Glu  Val Thr Gly 
    7265                 7270                 7275             


Leu Glu  Glu Gly Lys Trp Tyr  Ala Tyr Arg Val Lys  Ala Leu Asn 
    7280                 7285                 7290             


Arg Gln  Gly Ala Ser Lys Pro  Ser Arg Pro Thr Glu  Glu Ile Gln 
    7295                 7300                 7305             


Ala Val  Asp Thr Gln Glu Ala  Pro Glu Ile Phe Leu  Asp Val Lys 
    7310                 7315                 7320             


Leu Leu  Ala Gly Leu Thr Val  Lys Ala Gly Thr Lys  Ile Glu Leu 
    7325                 7330                 7335             


Pro Ala  Thr Val Thr Gly Lys  Pro Glu Pro Lys Ile  Thr Trp Thr 
    7340                 7345                 7350             


Lys Ala  Asp Met Ile Leu Lys  Gln Asp Lys Arg Ile  Thr Ile Glu 
    7355                 7360                 7365             


Asn Val  Pro Lys Lys Ser Thr  Val Thr Ile Val Asp  Ser Lys Arg 
    7370                 7375                 7380             


Ser Asp  Thr Gly Thr Tyr Ile  Ile Glu Ala Val Asn  Val Cys Gly 
    7385                 7390                 7395             


Arg Ala  Thr Ala Val Val Glu  Val Asn Val Leu Asp  Lys Pro Gly 
    7400                 7405                 7410             


Pro Pro  Ala Ala Phe Asp Ile  Thr Asp Val Thr Asn  Glu Ser Cys 
    7415                 7420                 7425             


Leu Leu  Thr Trp Asn Pro Pro  Arg Asp Asp Gly Gly  Ser Lys Ile 
    7430                 7435                 7440             


Thr Asn  Tyr Val Val Glu Arg  Arg Ala Thr Asp Ser  Glu Val Trp 
    7445                 7450                 7455             


His Lys  Leu Ser Ser Thr Val  Lys Asp Thr Asn Phe  Lys Ala Thr 
    7460                 7465                 7470             


Lys Leu  Ile Pro Asn Lys Glu  Tyr Ile Phe Arg Val  Ala Ala Glu 
    7475                 7480                 7485             


Asn Met  Tyr Gly Val Gly Glu  Pro Val Gln Ala Ser  Pro Ile Thr 
    7490                 7495                 7500             


Ala Lys  Tyr Gln Phe Asp Pro  Pro Gly Pro Pro Thr  Arg Leu Glu 
    7505                 7510                 7515             


Pro Ser  Asp Ile Thr Lys Asp  Ala Val Thr Leu Thr  Trp Cys Glu 
    7520                 7525                 7530             


Pro Asp  Asp Asp Gly Gly Ser  Pro Ile Thr Gly Tyr  Trp Val Glu 
    7535                 7540                 7545             


Arg Leu  Asp Pro Asp Thr Asp  Lys Trp Val Arg Cys  Asn Lys Met 
    7550                 7555                 7560             


Pro Val  Lys Asp Thr Thr Tyr  Arg Val Lys Gly Leu  Thr Asn Lys 
    7565                 7570                 7575             


Lys Lys  Tyr Arg Phe Arg Val  Leu Ala Glu Asn Leu  Ala Gly Pro 
    7580                 7585                 7590             


Gly Lys  Pro Ser Lys Ser Thr  Glu Pro Ile Leu Ile  Lys Asp Pro 
    7595                 7600                 7605             


Ile Asp  Pro Pro Trp Pro Pro  Gly Lys Pro Thr Val  Lys Asp Val 
    7610                 7615                 7620             


Gly Lys  Thr Ser Val Arg Leu  Asn Trp Thr Lys Pro  Glu His Asp 
    7625                 7630                 7635             


Gly Gly  Ala Lys Ile Glu Ser  Tyr Val Ile Glu Met  Leu Lys Thr 
    7640                 7645                 7650             


Gly Thr  Asp Glu Trp Val Arg  Val Ala Glu Gly Val  Pro Thr Thr 
    7655                 7660                 7665             


Gln His  Leu Leu Pro Gly Leu  Met Glu Gly Gln Glu  Tyr Ser Phe 
    7670                 7675                 7680             


Arg Val  Arg Ala Val Asn Lys  Ala Gly Glu Ser Glu  Pro Ser Glu 
    7685                 7690                 7695             


Pro Ser  Asp Pro Val Leu Cys  Arg Glu Lys Leu Tyr  Pro Pro Ser 
    7700                 7705                 7710             


Pro Pro  Arg Trp Leu Glu Val  Ile Asn Ile Thr Lys  Asn Thr Ala 
    7715                 7720                 7725             


Asp Leu  Lys Trp Thr Val Pro  Glu Lys Asp Gly Gly  Ser Pro Ile 
    7730                 7735                 7740             


Thr Asn  Tyr Ile Val Glu Lys  Arg Asp Val Arg Arg  Lys Gly Trp 
    7745                 7750                 7755             


Gln Thr  Val Asp Thr Thr Val  Lys Asp Thr Lys Cys  Thr Val Thr 
    7760                 7765                 7770             


Pro Leu  Thr Glu Gly Ser Leu  Tyr Val Phe Arg Val  Ala Ala Glu 
    7775                 7780                 7785             


Asn Ala  Ile Gly Gln Ser Asp  Tyr Thr Glu Ile Glu  Asp Ser Val 
    7790                 7795                 7800             


Leu Ala  Lys Asp Thr Phe Thr  Thr Pro Gly Pro Pro  Tyr Ala Leu 
    7805                 7810                 7815             


Ala Val  Val Asp Val Thr Lys  Arg His Val Asp Leu  Lys Trp Glu 
    7820                 7825                 7830             


Pro Pro  Lys Asn Asp Gly Gly  Arg Pro Ile Gln Arg  Tyr Val Ile 
    7835                 7840                 7845             


Glu Lys  Lys Glu Arg Leu Gly  Thr Arg Trp Val Lys  Ala Gly Lys 
    7850                 7855                 7860             


Thr Ala  Gly Pro Asp Cys Asn  Phe Arg Val Thr Asp  Val Ile Glu 
    7865                 7870                 7875             


Gly Thr  Glu Val Gln Phe Gln  Val Arg Ala Glu Asn  Glu Ala Gly 
    7880                 7885                 7890             


Val Gly  His Pro Ser Glu Pro  Thr Glu Ile Leu Ser  Ile Glu Asp 
    7895                 7900                 7905             


Pro Thr  Ser Pro Pro Ser Pro  Pro Leu Asp Leu His  Val Thr Asp 
    7910                 7915                 7920             


Ala Gly  Arg Lys His Ile Ala  Ile Ala Trp Lys Pro  Pro Glu Lys 
    7925                 7930                 7935             


Asn Gly  Gly Ser Pro Ile Ile  Gly Tyr His Val Glu  Met Cys Pro 
    7940                 7945                 7950             


Val Gly  Thr Glu Lys Trp Met  Arg Val Asn Ser Arg  Pro Ile Lys 
    7955                 7960                 7965             


Asp Leu  Lys Phe Lys Val Glu  Glu Gly Val Val Pro  Asp Lys Glu 
    7970                 7975                 7980             


Tyr Val  Leu Arg Val Arg Ala  Val Asn Ala Ile Gly  Val Ser Glu 
    7985                 7990                 7995             


Pro Ser  Glu Ile Ser Glu Asn  Val Val Ala Lys Asp  Pro Asp Cys 
    8000                 8005                 8010             


Lys Pro  Thr Ile Asp Leu Glu  Thr His Asp Ile Ile  Val Ile Glu 
    8015                 8020                 8025             


Gly Glu  Lys Leu Ser Ile Pro  Val Pro Phe Arg Ala  Val Pro Val 
    8030                 8035                 8040             


Pro Thr  Val Ser Trp His Lys  Asp Gly Lys Glu Val  Lys Ala Ser 
    8045                 8050                 8055             


Asp Arg  Leu Thr Met Lys Asn  Asp His Ile Ser Ala  His Leu Glu 
    8060                 8065                 8070             


Val Pro  Lys Ser Val Arg Ala  Asp Ala Gly Ile Tyr  Thr Ile Thr 
    8075                 8080                 8085             


Leu Glu  Asn Lys Leu Gly Ser  Ala Thr Ala Ser Ile  Asn Val Lys 
    8090                 8095                 8100             


Val Ile  Gly Leu Pro Gly Pro  Cys Lys Asp Ile Lys  Ala Ser Asp 
    8105                 8110                 8115             


Ile Thr  Lys Ser Ser Cys Lys  Leu Thr Trp Glu Pro  Pro Glu Phe 
    8120                 8125                 8130             


Asp Gly  Gly Thr Pro Ile Leu  His Tyr Val Leu Glu  Arg Arg Glu 
    8135                 8140                 8145             


Ala Gly  Arg Arg Thr Tyr Ile  Pro Val Met Ser Gly  Glu Asn Lys 
    8150                 8155                 8160             


Leu Ser  Trp Thr Val Lys Asp  Leu Ile Pro Asn Gly  Glu Tyr Phe 
    8165                 8170                 8175             


Phe Arg  Val Lys Ala Val Asn  Lys Val Gly Gly Gly  Glu Tyr Ile 
    8180                 8185                 8190             


Glu Leu  Lys Asn Pro Val Ile  Ala Gln Asp Pro Lys  Gln Pro Pro 
    8195                 8200                 8205             


Asp Pro  Pro Val Asp Val Glu  Val His Asn Pro Thr  Ala Glu Ala 
    8210                 8215                 8220             


Met Thr  Ile Thr Trp Lys Pro  Pro Leu Tyr Asp Gly  Gly Ser Lys 
    8225                 8230                 8235             


Ile Met  Gly Tyr Ile Ile Glu  Lys Ile Ala Lys Gly  Glu Glu Arg 
    8240                 8245                 8250             


Trp Lys  Arg Cys Asn Glu His  Leu Val Pro Ile Leu  Thr Tyr Thr 
    8255                 8260                 8265             


Ala Lys  Gly Leu Glu Glu Gly  Lys Glu Tyr Gln Phe  Arg Val Arg 
    8270                 8275                 8280             


Ala Glu  Asn Ala Ala Gly Ile  Ser Glu Pro Ser Arg  Ala Thr Pro 
    8285                 8290                 8295             


Pro Thr  Lys Ala Val Asp Pro  Ile Asp Ala Pro Lys  Val Ile Leu 
    8300                 8305                 8310             


Arg Thr  Ser Leu Glu Val Lys  Arg Gly Asp Glu Ile  Ala Leu Asp 
    8315                 8320                 8325             


Ala Ser  Ile Ser Gly Ser Pro  Tyr Pro Thr Ile Thr  Trp Ile Lys 
    8330                 8335                 8340             


Asp Glu  Asn Val Ile Val Pro  Glu Glu Ile Lys Lys  Arg Ala Ala 
    8345                 8350                 8355             


Pro Leu  Val Arg Arg Arg Lys  Gly Glu Val Gln Glu  Glu Glu Pro 
    8360                 8365                 8370             


Phe Val  Leu Pro Leu Thr Gln  Arg Leu Ser Ile Asp  Asn Ser Lys 
    8375                 8380                 8385             


Lys Gly  Glu Ser Gln Leu Arg  Val Arg Asp Ser Leu  Arg Pro Asp 
    8390                 8395                 8400             


His Gly  Leu Tyr Met Ile Lys  Val Glu Asn Asp His  Gly Ile Ala 
    8405                 8410                 8415             


Lys Ala  Pro Cys Thr Val Ser  Val Leu Asp Thr Pro  Gly Pro Pro 
    8420                 8425                 8430             


Ile Asn  Phe Val Phe Glu Asp  Ile Arg Lys Thr Ser  Val Leu Cys 
    8435                 8440                 8445             


Lys Trp  Glu Pro Pro Leu Asp  Asp Gly Gly Ser Glu  Ile Ile Asn 
    8450                 8455                 8460             


Tyr Thr  Leu Glu Lys Lys Asp  Lys Thr Lys Pro Asp  Ser Glu Trp 
    8465                 8470                 8475             


Ile Val  Val Thr Ser Thr Leu  Arg His Cys Lys Tyr  Ser Val Thr 
    8480                 8485                 8490             


Lys Leu  Ile Glu Gly Lys Glu  Tyr Leu Phe Arg Val  Arg Ala Glu 
    8495                 8500                 8505             


Asn Arg  Phe Gly Pro Gly Pro  Pro Cys Val Ser Lys  Pro Leu Val 
    8510                 8515                 8520             


Ala Lys  Asp Pro Phe Gly Pro  Pro Asp Ala Pro Asp  Lys Pro Ile 
    8525                 8530                 8535             


Val Glu  Asp Val Thr Ser Asn  Ser Met Leu Val Lys  Trp Asn Glu 
    8540                 8545                 8550             


Pro Lys  Asp Asn Gly Ser Pro  Ile Leu Gly Tyr Trp  Leu Glu Lys 
    8555                 8560                 8565             


Arg Glu  Val Asn Ser Thr His  Trp Ser Arg Val Asn  Lys Ser Leu 
    8570                 8575                 8580             


Leu Asn  Ala Leu Lys Ala Asn  Val Asp Gly Leu Leu  Glu Gly Leu 
    8585                 8590                 8595             


Thr Tyr  Val Phe Arg Val Cys  Ala Glu Asn Ala Ala  Gly Pro Gly 
    8600                 8605                 8610             


Lys Phe  Ser Pro Pro Ser Asp  Pro Lys Thr Ala His  Asp Pro Ile 
    8615                 8620                 8625             


Ser Pro  Pro Gly Pro Pro Ile  Pro Arg Val Thr Asp  Thr Ser Ser 
    8630                 8635                 8640             


Thr Thr  Ile Glu Leu Glu Trp  Glu Pro Pro Ala Phe  Asn Gly Gly 
    8645                 8650                 8655             


Gly Glu  Ile Val Gly Tyr Phe  Val Asp Lys Gln Leu  Val Gly Thr 
    8660                 8665                 8670             


Asn Glu  Trp Ser Arg Cys Thr  Glu Lys Met Ile Lys  Val Arg Gln 
    8675                 8680                 8685             


Tyr Thr  Val Lys Glu Ile Arg  Glu Gly Ala Asp Tyr  Lys Leu Arg 
    8690                 8695                 8700             


Val Ser  Ala Val Asn Ala Ala  Gly Glu Gly Pro Pro  Gly Glu Thr 
    8705                 8710                 8715             


Gln Pro  Val Thr Val Ala Glu  Pro Gln Glu Pro Pro  Ala Val Glu 
    8720                 8725                 8730             


Leu Asp  Val Ser Val Lys Gly  Gly Ile Gln Ile Met  Ala Gly Lys 
    8735                 8740                 8745             


Thr Leu  Arg Ile Pro Ala Val  Val Thr Gly Arg Pro  Val Pro Thr 
    8750                 8755                 8760             


Lys Val  Trp Thr Lys Glu Glu  Gly Glu Leu Asp Lys  Asp Arg Val 
    8765                 8770                 8775             


Val Ile  Asp Asn Val Gly Thr  Lys Ser Glu Leu Ile  Ile Lys Asp 
    8780                 8785                 8790             


Ala Leu  Arg Lys Asp His Gly  Arg Tyr Val Ile Thr  Ala Thr Asn 
    8795                 8800                 8805             


Ser Cys  Gly Ser Lys Phe Ala  Ala Ala Arg Val Glu  Val Phe Asp 
    8810                 8815                 8820             


Val Pro  Gly Pro Val Leu Asp  Leu Lys Pro Val Val  Thr Asn Arg 
    8825                 8830                 8835             


Lys Met  Cys Leu Leu Asn Trp  Ser Asp Pro Glu Asp  Asp Gly Gly 
    8840                 8845                 8850             


Ser Glu  Ile Thr Gly Phe Ile  Ile Glu Arg Lys Asp  Ala Lys Met 
    8855                 8860                 8865             


His Thr  Trp Arg Gln Pro Ile  Glu Thr Glu Arg Ser  Lys Cys Asp 
    8870                 8875                 8880             


Ile Thr  Gly Leu Leu Glu Gly  Gln Glu Tyr Lys Phe  Arg Val Ile 
    8885                 8890                 8895             


Ala Lys  Asn Lys Phe Gly Cys  Gly Pro Pro Val Glu  Ile Gly Pro 
    8900                 8905                 8910             


Ile Leu  Ala Val Asp Pro Leu  Gly Pro Pro Thr Ser  Pro Glu Arg 
    8915                 8920                 8925             


Leu Thr  Tyr Thr Glu Arg Thr  Lys Ser Thr Ile Thr  Leu Asp Trp 
    8930                 8935                 8940             


Lys Glu  Pro Arg Ser Asn Gly  Gly Ser Pro Ile Gln  Gly Tyr Ile 
    8945                 8950                 8955             


Ile Glu  Lys Arg Arg His Asp  Lys Pro Asp Phe Glu  Arg Val Asn 
    8960                 8965                 8970             


Lys Arg  Leu Cys Pro Thr Thr  Ser Phe Leu Val Glu  Asn Leu Asp 
    8975                 8980                 8985             


Glu His  Gln Met Tyr Glu Phe  Arg Val Lys Ala Val  Asn Glu Ile 
    8990                 8995                 9000             


Gly Glu  Ser Glu Pro Ser Leu  Pro Leu Asn Val Val  Ile Gln Asp 
    9005                 9010                 9015             


Asp Glu  Val Pro Pro Thr Ile  Lys Leu Arg Leu Ser  Val Arg Gly 
    9020                 9025                 9030             


Asp Thr  Ile Lys Val Lys Ala  Gly Glu Pro Val His  Ile Pro Ala 
    9035                 9040                 9045             


Asp Val  Thr Gly Leu Pro Met  Pro Lys Ile Glu Trp  Ser Lys Asn 
    9050                 9055                 9060             


Glu Thr  Val Ile Glu Lys Pro  Thr Asp Ala Leu Gln  Ile Thr Lys 
    9065                 9070                 9075             


Glu Glu  Val Ser Arg Ser Glu  Ala Lys Thr Glu Leu  Ser Ile Pro 
    9080                 9085                 9090             


Lys Ala  Val Arg Glu Asp Lys  Gly Thr Tyr Thr Val  Thr Ala Ser 
    9095                 9100                 9105             


Asn Arg  Leu Gly Ser Val Phe  Arg Asn Val His Val  Glu Val Tyr 
    9110                 9115                 9120             


Asp Arg  Pro Ser Pro Pro Arg  Asn Leu Ala Val Thr  Asp Ile Lys 
    9125                 9130                 9135             


Ala Glu  Ser Cys Tyr Leu Thr  Trp Asp Ala Pro Leu  Asp Asn Gly 
    9140                 9145                 9150             


Gly Ser  Glu Ile Thr His Tyr  Val Ile Asp Lys Arg  Asp Ala Ser 
    9155                 9160                 9165             


Arg Lys  Lys Ala Glu Trp Glu  Glu Val Thr Asn Thr  Ala Val Glu 
    9170                 9175                 9180             


Lys Arg  Tyr Gly Ile Trp Lys  Leu Ile Pro Asn Gly  Gln Tyr Glu 
    9185                 9190                 9195             


Phe Arg  Val Arg Ala Val Asn  Lys Tyr Gly Ile Ser  Asp Glu Cys 
    9200                 9205                 9210             


Lys Ser  Asp Lys Val Val Ile  Gln Asp Pro Tyr Arg  Leu Pro Gly 
    9215                 9220                 9225             


Pro Pro  Gly Lys Pro Lys Val  Leu Ala Arg Thr Lys  Gly Ser Met 
    9230                 9235                 9240             


Leu Val  Ser Trp Thr Pro Pro  Leu Asp Asn Gly Gly  Ser Pro Ile 
    9245                 9250                 9255             


Thr Gly  Tyr Trp Leu Glu Lys  Arg Glu Glu Gly Ser  Pro Tyr Trp 
    9260                 9265                 9270             


Ser Arg  Val Ser Arg Ala Pro  Ile Thr Lys Val Gly  Leu Lys Gly 
    9275                 9280                 9285             


Val Glu  Phe Asn Val Pro Arg  Leu Leu Glu Gly Val  Lys Tyr Gln 
    9290                 9295                 9300             


Phe Arg  Ala Met Ala Ile Asn  Ala Ala Gly Ile Gly  Pro Pro Ser 
    9305                 9310                 9315             


Glu Pro  Ser Asp Pro Glu Val  Ala Gly Asp Pro Ile  Phe Pro Pro 
    9320                 9325                 9330             


Gly Pro  Pro Ser Cys Pro Glu  Val Lys Asp Lys Thr  Lys Ser Ser 
    9335                 9340                 9345             


Ile Ser  Leu Gly Trp Lys Pro  Pro Ala Lys Asp Gly  Gly Ser Pro 
    9350                 9355                 9360             


Ile Lys  Gly Tyr Ile Val Glu  Met Gln Glu Glu Gly  Thr Thr Asp 
    9365                 9370                 9375             


Trp Lys  Arg Val Asn Glu Pro  Asp Lys Leu Ile Thr  Thr Cys Glu 
    9380                 9385                 9390             


Cys Val  Val Pro Asn Leu Lys  Glu Leu Arg Lys Tyr  Arg Phe Arg 
    9395                 9400                 9405             


Val Lys  Ala Val Asn Glu Ala  Gly Glu Ser Glu Pro  Ser Asp Thr 
    9410                 9415                 9420             


Thr Gly  Glu Ile Pro Ala Thr  Asp Ile Gln Glu Glu  Pro Glu Val 
    9425                 9430                 9435             


Phe Ile  Asp Ile Gly Ala Gln  Asp Cys Leu Val Cys  Lys Ala Gly 
    9440                 9445                 9450             


Ser Gln  Ile Arg Ile Pro Ala  Val Ile Lys Gly Arg  Pro Thr Pro 
    9455                 9460                 9465             


Lys Ser  Ser Trp Glu Phe Asp  Gly Lys Ala Lys Lys  Ala Met Lys 
    9470                 9475                 9480             


Asp Gly  Val His Asp Ile Pro  Glu Asp Ala Gln Leu  Glu Thr Ala 
    9485                 9490                 9495             


Glu Asn  Ser Ser Val Ile Ile  Ile Pro Glu Cys Lys  Arg Ser His 
    9500                 9505                 9510             


Thr Gly  Lys Tyr Ser Ile Thr  Ala Lys Asn Lys Ala  Gly Gln Lys 
    9515                 9520                 9525             


Thr Ala  Asn Cys Arg Val Lys  Val Met Asp Val Pro  Gly Pro Pro 
    9530                 9535                 9540             


Lys Asp  Leu Lys Val Ser Asp  Ile Thr Arg Gly Ser  Cys Arg Leu 
    9545                 9550                 9555             


Ser Trp  Lys Met Pro Asp Asp  Asp Gly Gly Asp Arg  Ile Lys Gly 
    9560                 9565                 9570             


Tyr Val  Ile Glu Lys Arg Thr  Ile Asp Gly Lys Ala  Trp Thr Lys 
    9575                 9580                 9585             


Val Asn  Pro Asp Cys Gly Ser  Thr Thr Phe Val Val  Pro Asp Leu 
    9590                 9595                 9600             


Leu Ser  Glu Gln Gln Tyr Phe  Phe Arg Val Arg Ala  Glu Asn Arg 
    9605                 9610                 9615             


Phe Gly  Ile Gly Pro Pro Val  Glu Thr Ile Gln Arg  Thr Thr Ala 
    9620                 9625                 9630             


Arg Asp  Pro Ile Tyr Pro Pro  Asp Pro Pro Ile Lys  Leu Lys Ile 
    9635                 9640                 9645             


Gly Leu  Ile Thr Lys Asn Thr  Val His Leu Ser Trp  Lys Pro Pro 
    9650                 9655                 9660             


Lys Asn  Asp Gly Gly Ser Pro  Val Thr His Tyr Ile  Val Glu Cys 
    9665                 9670                 9675             


Leu Ala  Trp Asp Pro Thr Gly  Thr Lys Lys Glu Ala  Trp Arg Gln 
    9680                 9685                 9690             


Cys Asn  Lys Arg Asp Val Glu  Glu Leu Gln Phe Thr  Val Glu Asp 
    9695                 9700                 9705             


Leu Val  Glu Gly Gly Glu Tyr  Glu Phe Arg Val Lys  Ala Val Asn 
    9710                 9715                 9720             


Ala Ala  Gly Val Ser Lys Pro  Ser Ala Thr Val Gly  Pro Cys Asp 
    9725                 9730                 9735             


Cys Gln  Arg Pro Asp Met Pro  Pro Ser Ile Asp Leu  Lys Glu Phe 
    9740                 9745                 9750             


Met Glu  Val Glu Glu Gly Thr  Asn Val Asn Ile Val  Ala Lys Ile 
    9755                 9760                 9765             


Lys Gly  Val Pro Phe Pro Thr  Leu Thr Trp Phe Lys  Ala Pro Pro 
    9770                 9775                 9780             


Lys Lys  Pro Asp Asn Lys Glu  Pro Val Leu Tyr Asp  Thr His Val 
    9785                 9790                 9795             


Asn Lys  Leu Val Val Asp Asp  Thr Cys Thr Leu Val  Ile Pro Gln 
    9800                 9805                 9810             


Ser Arg  Arg Ser Asp Thr Gly  Leu Tyr Thr Ile Thr  Ala Val Asn 
    9815                 9820                 9825             


Asn Leu  Gly Thr Ala Ser Lys  Glu Met Arg Leu Asn  Val Leu Gly 
    9830                 9835                 9840             


Arg Pro  Gly Pro Pro Val Gly  Pro Ile Lys Phe Glu  Ser Val Ser 
    9845                 9850                 9855             


Ala Asp  Gln Met Thr Leu Ser  Trp Phe Pro Pro Lys  Asp Asp Gly 
    9860                 9865                 9870             


Gly Ser  Lys Ile Thr Asn Tyr  Val Ile Glu Lys Arg  Glu Ala Asn 
    9875                 9880                 9885             


Arg Lys  Thr Trp Val His Val  Ser Ser Glu Pro Lys  Glu Cys Thr 
    9890                 9895                 9900             


Tyr Thr  Ile Pro Lys Leu Leu  Glu Gly His Glu Tyr  Val Phe Arg 
    9905                 9910                 9915             


Ile Met  Ala Gln Asn Lys Tyr  Gly Ile Gly Glu Pro  Leu Asp Ser 
    9920                 9925                 9930             


Glu Pro  Glu Thr Ala Arg Asn  Leu Phe Ser Val Pro  Gly Ala Pro 
    9935                 9940                 9945             


Asp Lys  Pro Thr Val Ser Ser  Val Thr Arg Asn Ser  Met Thr Val 
    9950                 9955                 9960             


Asn Trp  Glu Glu Pro Glu Tyr  Asp Gly Gly Ser Pro  Val Thr Gly 
    9965                 9970                 9975             


Tyr Trp  Leu Glu Met Lys Asp  Thr Thr Ser Lys Arg  Trp Lys Arg 
    9980                 9985                 9990             


Val Asn  Arg Asp Pro Ile Lys   Ala Met Thr Leu Gly   Val Ser Tyr 
    9995                 10000                 10005             


Lys Val   Thr Gly Leu Ile Glu   Gly Ser Asp Tyr Gln   Phe Arg Val 
    10010                 10015                 10020             


Tyr Ala   Ile Asn Ala Ala Gly   Val Gly Pro Ala Ser   Leu Pro Ser 
    10025                 10030                 10035             


Asp Pro   Ala Thr Ala Arg Asp   Pro Ile Ala Pro Pro   Gly Pro Pro 
    10040                 10045                 10050             


Phe Pro   Lys Val Thr Asp Trp   Thr Lys Ser Ser Ala   Asp Leu Glu 
    10055                 10060                 10065             


Trp Ser   Pro Pro Leu Lys Asp   Gly Gly Ser Lys Val   Thr Gly Tyr 
    10070                 10075                 10080             


Ile Val   Glu Tyr Lys Glu Glu   Gly Lys Glu Glu Trp   Glu Lys Gly 
    10085                 10090                 10095             


Lys Asp   Lys Glu Val Arg Gly   Thr Lys Leu Val Val   Thr Gly Leu 
    10100                 10105                 10110             


Lys Glu   Gly Ala Phe Tyr Lys   Phe Arg Val Ser Ala   Val Asn Ile 
    10115                 10120                 10125             


Ala Gly   Ile Gly Glu Pro Gly   Glu Val Thr Asp Val   Ile Glu Met 
    10130                 10135                 10140             


Lys Asp   Arg Leu Val Ser Pro   Asp Leu Gln Leu Asp   Ala Ser Val 
    10145                 10150                 10155             


Arg Asp   Arg Ile Val Val His   Ala Gly Gly Val Ile   Arg Ile Ile 
    10160                 10165                 10170             


Ala Tyr   Val Ser Gly Lys Pro   Pro Pro Thr Val Thr   Trp Asn Met 
    10175                 10180                 10185             


Asn Glu   Arg Thr Leu Pro Gln   Glu Ala Thr Ile Glu   Thr Thr Ala 
    10190                 10195                 10200             


Ile Ser   Ser Ser Met Val Ile   Lys Asn Cys Gln Arg   Ser His Gln 
    10205                 10210                 10215             


Gly Val   Tyr Ser Leu Leu Ala   Lys Asn Glu Ala Gly   Glu Arg Lys 
    10220                 10225                 10230             


Lys Thr   Ile Ile Val Asp Val   Leu Asp Val Pro Gly   Pro Val Gly 
    10235                 10240                 10245             


Thr Pro   Phe Leu Ala His Asn   Leu Thr Asn Glu Ser   Cys Lys Leu 
    10250                 10255                 10260             


Thr Trp   Phe Ser Pro Glu Asp   Asp Gly Gly Ser Pro   Ile Thr Asn 
    10265                 10270                 10275             


Tyr Val   Ile Glu Lys Arg Glu   Ser Asp Arg Arg Ala   Trp Thr Pro 
    10280                 10285                 10290             


Val Thr   Tyr Thr Val Thr Arg   Gln Asn Ala Thr Val   Gln Gly Leu 
    10295                 10300                 10305             


Ile Gln   Gly Lys Ala Tyr Phe   Phe Arg Ile Ala Ala   Glu Asn Ser 
    10310                 10315                 10320             


Ile Gly   Met Gly Pro Phe Val   Glu Thr Ser Glu Ala   Leu Val Ile 
    10325                 10330                 10335             


Arg Glu   Pro Ile Thr Val Pro   Glu Arg Pro Glu Asp   Leu Glu Val 
    10340                 10345                 10350             


Lys Glu   Val Thr Lys Asn Thr   Val Thr Leu Thr Trp   Asn Pro Pro 
    10355                 10360                 10365             


Lys Tyr   Asp Gly Gly Ser Glu   Ile Ile Asn Tyr Val   Leu Glu Ser 
    10370                 10375                 10380             


Arg Leu   Ile Gly Thr Glu Lys   Phe His Lys Val Thr   Asn Asp Asn 
    10385                 10390                 10395             


Leu Leu   Ser Arg Lys Tyr Thr   Val Lys Gly Leu Lys   Glu Gly Asp 
    10400                 10405                 10410             


Thr Tyr   Glu Tyr Arg Val Ser   Ala Val Asn Ile Val   Gly Gln Gly 
    10415                 10420                 10425             


Lys Pro   Ser Phe Cys Thr Lys   Pro Ile Thr Cys Lys   Asp Glu Leu 
    10430                 10435                 10440             


Ala Pro   Pro Thr Leu His Leu   Asp Phe Arg Asp Lys   Leu Thr Ile 
    10445                 10450                 10455             


Arg Val   Gly Glu Ala Phe Ala   Leu Thr Gly Arg Tyr   Ser Gly Lys 
    10460                 10465                 10470             


Pro Lys   Pro Lys Val Ser Trp   Phe Lys Asp Glu Ala   Asp Val Leu 
    10475                 10480                 10485             


Glu Asp   Asp Arg Thr His Ile   Lys Thr Thr Pro Ala   Thr Leu Ala 
    10490                 10495                 10500             


Leu Glu   Lys Ile Lys Ala Lys   Arg Ser Asp Ser Gly   Lys Tyr Cys 
    10505                 10510                 10515             


Val Val   Val Glu Asn Ser Thr   Gly Ser Arg Lys Gly   Phe Cys Gln 
    10520                 10525                 10530             


Val Asn   Val Val Asp Arg Pro   Gly Pro Pro Val Gly   Pro Val Ser 
    10535                 10540                 10545             


Phe Asp   Glu Val Thr Lys Asp   Tyr Met Val Ile Ser   Trp Lys Pro 
    10550                 10555                 10560             


Pro Leu   Asp Asp Gly Gly Ser   Lys Ile Thr Asn Tyr   Ile Ile Glu 
    10565                 10570                 10575             


Lys Lys   Glu Val Gly Lys Asp   Val Trp Met Pro Val   Thr Ser Ala 
    10580                 10585                 10590             


Ser Ala   Lys Thr Thr Cys Lys   Val Ser Lys Leu Leu   Glu Gly Lys 
    10595                 10600                 10605             


Asp Tyr   Ile Phe Arg Ile His   Ala Glu Asn Leu Tyr   Gly Ile Ser 
    10610                 10615                 10620             


Asp Pro   Leu Val Ser Asp Ser   Met Lys Ala Lys Asp   Arg Phe Arg 
    10625                 10630                 10635             


Val Pro   Asp Ala Pro Asp Gln   Pro Ile Val Thr Glu   Val Thr Lys 
    10640                 10645                 10650             


Asp Ser   Ala Leu Val Thr Trp   Asn Lys Pro His Asp   Gly Gly Lys 
    10655                 10660                 10665             


Pro Ile   Thr Asn Tyr Ile Leu   Glu Lys Arg Glu Thr   Met Ser Lys 
    10670                 10675                 10680             


Arg Trp   Ala Arg Val Thr Lys   Asp Pro Ile His Pro   Tyr Thr Lys 
    10685                 10690                 10695             


Phe Arg   Val Pro Asp Leu Leu   Glu Gly Cys Gln Tyr   Glu Phe Arg 
    10700                 10705                 10710             


Val Ser   Ala Glu Asn Glu Ile   Gly Ile Gly Asp Pro   Ser Pro Pro 
    10715                 10720                 10725             


Ser Lys   Pro Val Phe Ala Lys   Asp Pro Ile Ala Lys   Pro Ser Pro 
    10730                 10735                 10740             


Pro Val   Asn Pro Glu Ala Ile   Asp Thr Thr Cys Asn   Ser Val Asp 
    10745                 10750                 10755             


Leu Thr   Trp Gln Pro Pro Arg   His Asp Gly Gly Ser   Lys Ile Leu 
    10760                 10765                 10770             


Gly Tyr   Ile Val Glu Tyr Gln   Lys Val Gly Asp Glu   Glu Trp Arg 
    10775                 10780                 10785             


Arg Ala   Asn His Thr Pro Glu   Ser Cys Pro Glu Thr   Lys Tyr Lys 
    10790                 10795                 10800             


Val Thr   Gly Leu Arg Asp Gly   Gln Thr Tyr Lys Phe   Arg Val Leu 
    10805                 10810                 10815             


Ala Val   Asn Ala Ala Gly Glu   Ser Asp Pro Ala His   Val Pro Glu 
    10820                 10825                 10830             


Pro Val   Leu Val Lys Asp Arg   Leu Glu Pro Pro Glu   Leu Ile Leu 
    10835                 10840                 10845             


Asp Ala   Asn Met Ala Arg Glu   Gln His Ile Lys Val   Gly Asp Thr 
    10850                 10855                 10860             


Leu Arg   Leu Ser Ala Ile Ile   Lys Gly Val Pro Phe   Pro Lys Val 
    10865                 10870                 10875             


Thr Trp   Lys Lys Glu Asp Arg   Asp Ala Pro Thr Lys   Ala Arg Ile 
    10880                 10885                 10890             


Asp Val   Thr Pro Val Gly Ser   Lys Leu Glu Ile Arg   Asn Ala Ala 
    10895                 10900                 10905             


His Glu   Asp Gly Gly Ile Tyr   Ser Leu Thr Val Glu   Asn Pro Ala 
    10910                 10915                 10920             


Gly Ser   Lys Thr Val Ser Val   Lys Val Leu Val Leu   Asp Lys Pro 
    10925                 10930                 10935             


Gly Pro   Pro Arg Asp Leu Glu   Val Ser Glu Ile Arg   Lys Asp Ser 
    10940                 10945                 10950             


Cys Tyr   Leu Thr Trp Lys Glu   Pro Leu Asp Asp Gly   Gly Ser Val 
    10955                 10960                 10965             


Ile Thr   Asn Tyr Val Val Glu   Arg Arg Asp Val Ala   Ser Ala Gln 
    10970                 10975                 10980             


Trp Ser   Pro Leu Ser Ala Thr   Ser Lys Lys Lys Ser   His Phe Ala 
    10985                 10990                 10995             


Lys His   Leu Asn Glu Gly Asn   Gln Tyr Leu Phe Arg   Val Ala Ala 
    11000                 11005                 11010             


Glu Asn   Gln Tyr Gly Arg Gly   Pro Phe Val Glu Thr   Pro Lys Pro 
    11015                 11020                 11025             


Ile Lys   Ala Leu Asp Pro Leu   His Pro Pro Gly Pro   Pro Lys Asp 
    11030                 11035                 11040             


Leu His   His Val Asp Val Asp   Lys Thr Glu Val Ser   Leu Val Trp 
    11045                 11050                 11055             


Asn Lys   Pro Asp Arg Asp Gly   Gly Ser Pro Ile Thr   Gly Tyr Leu 
    11060                 11065                 11070             


Val Glu   Tyr Gln Glu Glu Gly   Thr Gln Asp Trp Ile   Lys Phe Lys 
    11075                 11080                 11085             


Thr Val   Thr Asn Leu Glu Cys   Val Val Thr Gly Leu   Gln Gln Gly 
    11090                 11095                 11100             


Lys Thr   Tyr Arg Phe Arg Val   Lys Ala Glu Asn Ile   Val Gly Leu 
    11105                 11110                 11115             


Gly Leu   Pro Asp Thr Thr Ile   Pro Ile Glu Cys Gln   Glu Lys Leu 
    11120                 11125                 11130             


Val Pro   Pro Ser Val Glu Leu   Asp Val Lys Leu Ile   Glu Gly Leu 
    11135                 11140                 11145             


Val Val   Lys Ala Gly Thr Thr   Val Arg Phe Pro Ala   Ile Ile Arg 
    11150                 11155                 11160             


Gly Val   Pro Val Pro Thr Ala   Lys Trp Thr Thr Asp   Gly Ser Glu 
    11165                 11170                 11175             


Ile Lys   Thr Asp Glu His Tyr   Thr Val Glu Thr Asp   Asn Phe Ser 
    11180                 11185                 11190             


Ser Val   Leu Thr Ile Lys Asn   Cys Leu Arg Arg Asp   Thr Gly Glu 
    11195                 11200                 11205             


Tyr Gln   Ile Thr Val Ser Asn   Ala Ala Gly Ser Lys   Thr Val Ala 
    11210                 11215                 11220             


Val His   Leu Thr Val Leu Asp   Val Pro Gly Pro Pro   Thr Gly Pro 
    11225                 11230                 11235             


Ile Asn   Ile Leu Asp Val Thr   Pro Glu His Met Thr   Ile Ser Trp 
    11240                 11245                 11250             


Gln Pro   Pro Lys Asp Asp Gly   Gly Ser Pro Val Ile   Asn Tyr Ile 
    11255                 11260                 11265             


Val Glu   Lys Gln Asp Thr Arg   Lys Asp Thr Trp Gly   Val Val Ser 
    11270                 11275                 11280             


Ser Gly   Ser Ser Lys Thr Lys   Leu Lys Ile Pro His   Leu Gln Lys 
    11285                 11290                 11295             


Gly Cys   Glu Tyr Val Phe Arg   Val Arg Ala Glu Asn   Lys Ile Gly 
    11300                 11305                 11310             


Val Gly   Pro Pro Leu Asp Ser   Thr Pro Thr Val Ala   Lys His Lys 
    11315                 11320                 11325             


Phe Ser   Pro Pro Ser Pro Pro   Gly Lys Pro Val Val   Thr Asp Ile 
    11330                 11335                 11340             


Thr Glu   Asn Ala Ala Thr Val   Ser Trp Thr Leu Pro   Lys Ser Asp 
    11345                 11350                 11355             


Gly Gly   Ser Pro Ile Thr Gly   Tyr Tyr Met Glu Arg   Arg Glu Val 
    11360                 11365                 11370             


Thr Gly   Lys Trp Val Arg Val   Asn Lys Thr Pro Ile   Ala Asp Leu 
    11375                 11380                 11385             


Lys Phe   Arg Val Thr Gly Leu   Tyr Glu Gly Asn Thr   Tyr Glu Phe 
    11390                 11395                 11400             


Arg Val   Phe Ala Glu Asn Leu   Ala Gly Leu Ser Lys   Pro Ser Pro 
    11405                 11410                 11415             


Ser Ser   Asp Pro Ile Lys Ala   Cys Arg Pro Ile Lys   Pro Pro Gly 
    11420                 11425                 11430             


Pro Pro   Ile Asn Pro Lys Leu   Lys Asp Lys Ser Arg   Glu Thr Ala 
    11435                 11440                 11445             


Asp Leu   Val Trp Thr Lys Pro   Leu Ser Asp Gly Gly   Ser Pro Ile 
    11450                 11455                 11460             


Leu Gly   Tyr Val Val Glu Cys   Gln Lys Pro Gly Thr   Ala Gln Trp 
    11465                 11470                 11475             


Asn Arg   Ile Asn Lys Asp Glu   Leu Ile Arg Gln Cys   Ala Phe Arg 
    11480                 11485                 11490             


Val Pro   Gly Leu Ile Glu Gly   Asn Glu Tyr Arg Phe   Arg Ile Lys 
    11495                 11500                 11505             


Ala Ala   Asn Ile Val Gly Glu   Gly Glu Pro Arg Glu   Leu Ala Glu 
    11510                 11515                 11520             


Ser Val   Ile Ala Lys Asp Ile   Leu His Pro Pro Glu   Val Glu Leu 
    11525                 11530                 11535             


Asp Val   Thr Cys Arg Asp Val   Ile Thr Val Arg Val   Gly Gln Thr 
    11540                 11545                 11550             


Ile Arg   Ile Leu Ala Arg Val   Lys Gly Arg Pro Glu   Pro Asp Ile 
    11555                 11560                 11565             


Thr Trp   Thr Lys Glu Gly Lys   Val Leu Val Arg Glu   Lys Arg Val 
    11570                 11575                 11580             


Asp Leu   Ile Gln Asp Leu Pro   Arg Val Glu Leu Gln   Ile Lys Glu 
    11585                 11590                 11595             


Ala Val   Arg Ala Asp His Gly   Lys Tyr Ile Ile Ser   Ala Lys Asn 
    11600                 11605                 11610             


Ser Ser   Gly His Ala Gln Gly   Ser Ala Ile Val Asn   Val Leu Asp 
    11615                 11620                 11625             


Arg Pro   Gly Pro Cys Gln Asn   Leu Lys Val Thr Asn   Val Thr Lys 
    11630                 11635                 11640             


Glu Asn   Cys Thr Ile Ser Trp   Glu Asn Pro Leu Asp   Asn Gly Gly 
    11645                 11650                 11655             


Ser Glu   Ile Thr Asn Phe Ile   Val Glu Tyr Arg Lys   Pro Asn Gln 
    11660                 11665                 11670             


Lys Gly   Trp Ser Ile Val Ala   Ser Asp Val Thr Lys   Arg Leu Ile 
    11675                 11680                 11685             


Lys Ala   Asn Leu Leu Ala Asn   Asn Glu Tyr Tyr Phe   Arg Val Cys 
    11690                 11695                 11700             


Ala Glu   Asn Lys Val Gly Val   Gly Pro Thr Ile Glu   Thr Lys Thr 
    11705                 11710                 11715             


Pro Ile   Leu Ala Ile Asn Pro   Ile Asp Arg Pro Gly   Glu Pro Glu 
    11720                 11725                 11730             


Asn Leu   His Ile Ala Asp Lys   Gly Lys Thr Phe Val   Tyr Leu Lys 
    11735                 11740                 11745             


Trp Arg   Arg Pro Asp Tyr Asp   Gly Gly Ser Pro Asn   Leu Ser Tyr 
    11750                 11755                 11760             


His Val   Glu Arg Arg Leu Lys   Gly Ser Asp Asp Trp   Glu Arg Val 
    11765                 11770                 11775             


His Lys   Gly Ser Ile Lys Glu   Thr His Tyr Met Val   Asp Arg Cys 
    11780                 11785                 11790             


Val Glu   Asn Gln Ile Tyr Glu   Phe Arg Val Gln Thr   Lys Asn Glu 
    11795                 11800                 11805             


Gly Gly   Glu Ser Asp Trp Val   Lys Thr Glu Glu Val   Val Val Lys 
    11810                 11815                 11820             


Glu Asp   Leu Gln Lys Pro Val   Leu Asp Leu Lys Leu   Ser Gly Val 
    11825                 11830                 11835             


Leu Thr   Val Lys Ala Gly Asp   Thr Ile Arg Leu Glu   Ala Gly Val 
    11840                 11845                 11850             


Arg Gly   Lys Pro Phe Pro Glu   Val Ala Trp Thr Lys   Asp Lys Asp 
    11855                 11860                 11865             


Ala Thr   Asp Leu Thr Arg Ser   Pro Arg Val Lys Ile   Asp Thr Arg 
    11870                 11875                 11880             


Ala Asp   Ser Ser Lys Phe Ser   Leu Thr Lys Ala Lys   Arg Ser Asp 
    11885                 11890                 11895             


Gly Gly   Lys Tyr Val Val Thr   Ala Thr Asn Thr Ala   Gly Ser Phe 
    11900                 11905                 11910             


Val Ala   Tyr Ala Thr Val Asn   Val Leu Asp Lys Pro   Gly Pro Val 
    11915                 11920                 11925             


Arg Asn   Leu Lys Ile Val Asp   Val Ser Ser Asp Arg   Cys Thr Val 
    11930                 11935                 11940             


Cys Trp   Asp Pro Pro Glu Asp   Asp Gly Gly Cys Glu   Ile Gln Asn 
    11945                 11950                 11955             


Tyr Ile   Leu Glu Lys Cys Glu   Thr Lys Arg Met Val   Trp Ser Thr 
    11960                 11965                 11970             


Tyr Ser   Ala Thr Val Leu Thr   Pro Gly Thr Thr Val   Thr Arg Leu 
    11975                 11980                 11985             


Ile Glu   Gly Asn Glu Tyr Ile   Phe Arg Val Arg Ala   Glu Asn Lys 
    11990                 11995                 12000             


Ile Gly   Thr Gly Pro Pro Thr   Glu Ser Lys Pro Val   Ile Ala Lys 
    12005                 12010                 12015             


Thr Lys   Tyr Asp Lys Pro Gly   Arg Pro Asp Pro Pro   Glu Val Thr 
    12020                 12025                 12030             


Lys Val   Ser Lys Glu Glu Met   Thr Val Val Trp Asn   Pro Pro Glu 
    12035                 12040                 12045             


Tyr Asp   Gly Gly Lys Ser Ile   Thr Gly Tyr Phe Leu   Glu Lys Lys 
    12050                 12055                 12060             


Glu Lys   His Ser Thr Arg Trp   Val Pro Val Asn Lys   Ser Ala Ile 
    12065                 12070                 12075             


Pro Glu   Arg Arg Met Lys Val   Gln Asn Leu Leu Pro   Asp His Glu 
    12080                 12085                 12090             


Tyr Gln   Phe Arg Val Lys Ala   Glu Asn Glu Ile Gly   Ile Gly Glu 
    12095                 12100                 12105             


Pro Ser   Leu Pro Ser Arg Pro   Val Val Ala Lys Asp   Pro Ile Glu 
    12110                 12115                 12120             


Pro Pro   Gly Pro Pro Thr Asn   Phe Arg Val Val Asp   Thr Thr Lys 
    12125                 12130                 12135             


His Ser   Ile Thr Leu Gly Trp   Gly Lys Pro Val Tyr   Asp Gly Gly 
    12140                 12145                 12150             


Ala Pro   Ile Ile Gly Tyr Val   Val Glu Met Arg Pro   Lys Ile Ala 
    12155                 12160                 12165             


Asp Ala   Ser Pro Asp Glu Gly   Trp Lys Arg Cys Asn   Ala Ala Ala 
    12170                 12175                 12180             


Gln Leu   Val Arg Lys Glu Phe   Thr Val Thr Ser Leu   Asp Glu Asn 
    12185                 12190                 12195             


Gln Glu   Tyr Glu Phe Arg Val   Cys Ala Gln Asn Gln   Val Gly Ile 
    12200                 12205                 12210             


Gly Arg   Pro Ala Glu Leu Lys   Glu Ala Ile Lys Pro   Lys Glu Ile 
    12215                 12220                 12225             


Leu Glu   Pro Pro Glu Ile Asp   Leu Asp Ala Ser Met   Arg Lys Leu 
    12230                 12235                 12240             


Val Ile   Val Arg Ala Gly Cys   Pro Ile Arg Leu Phe   Ala Ile Val 
    12245                 12250                 12255             


Arg Gly   Arg Pro Ala Pro Lys   Val Thr Trp Arg Lys   Val Gly Ile 
    12260                 12265                 12270             


Asp Asn   Val Val Arg Lys Gly   Gln Val Asp Leu Val   Asp Thr Met 
    12275                 12280                 12285             


Ala Phe   Leu Val Ile Pro Asn   Ser Thr Arg Asp Asp   Ser Gly Lys 
    12290                 12295                 12300             


Tyr Ser   Leu Thr Leu Val Asn   Pro Ala Gly Glu Lys   Ala Val Phe 
    12305                 12310                 12315             


Val Asn   Val Arg Val Leu Asp   Thr Pro Gly Pro Val   Ser Asp Leu 
    12320                 12325                 12330             


Lys Val   Ser Asp Val Thr Lys   Thr Ser Cys His Val   Ser Trp Ala 
    12335                 12340                 12345             


Pro Pro   Glu Asn Asp Gly Gly   Ser Gln Val Thr His   Tyr Ile Val 
    12350                 12355                 12360             


Glu Lys   Arg Glu Ala Asp Arg   Lys Thr Trp Ser Thr   Val Thr Pro 
    12365                 12370                 12375             


Glu Val   Lys Lys Thr Ser Phe   His Val Thr Asn Leu   Val Pro Gly 
    12380                 12385                 12390             


Asn Glu   Tyr Tyr Phe Arg Val   Thr Ala Val Asn Glu   Tyr Gly Pro 
    12395                 12400                 12405             


Gly Val   Pro Thr Asp Val Pro   Lys Pro Val Leu Ala   Ser Asp Pro 
    12410                 12415                 12420             


Leu Ser   Glu Pro Asp Pro Pro   Arg Lys Leu Glu Val   Thr Glu Met 
    12425                 12430                 12435             


Thr Lys   Asn Ser Ala Thr Leu   Ala Trp Leu Pro Pro   Leu Arg Asp 
    12440                 12445                 12450             


Gly Gly   Ala Lys Ile Asp Gly   Tyr Ile Thr Ser Tyr   Arg Glu Glu 
    12455                 12460                 12465             


Glu Gln   Pro Ala Asp Arg Trp   Thr Glu Tyr Ser Val   Val Lys Asp 
    12470                 12475                 12480             


Leu Ser   Leu Val Val Thr Gly   Leu Lys Glu Gly Lys   Lys Tyr Lys 
    12485                 12490                 12495             


Phe Arg   Val Ala Ala Arg Asn   Ala Val Gly Val Ser   Leu Pro Arg 
    12500                 12505                 12510             


Glu Ala   Glu Gly Val Tyr Glu   Ala Lys Glu Gln Leu   Leu Pro Pro 
    12515                 12520                 12525             


Lys Ile   Leu Met Pro Glu Gln   Ile Thr Ile Lys Ala   Gly Lys Lys 
    12530                 12535                 12540             


Leu Arg   Ile Glu Ala His Val   Tyr Gly Lys Pro His   Pro Thr Cys 
    12545                 12550                 12555             


Lys Trp   Lys Lys Gly Glu Asp   Glu Val Val Thr Ser   Ser His Leu 
    12560                 12565                 12570             


Ala Val   His Lys Ala Asp Ser   Ser Ser Ile Leu Ile   Ile Lys Asp 
    12575                 12580                 12585             


Val Thr   Arg Lys Asp Ser Gly   Tyr Tyr Ser Leu Thr   Ala Glu Asn 
    12590                 12595                 12600             


Ser Ser   Gly Thr Asp Thr Gln   Lys Ile Lys Val Val   Val Met Asp 
    12605                 12610                 12615             


Ala Pro   Gly Pro Pro Gln Pro   Pro Phe Asp Ile Ser   Asp Ile Asp 
    12620                 12625                 12630             


Ala Asp   Ala Cys Ser Leu Ser   Trp His Ile Pro Leu   Glu Asp Gly 
    12635                 12640                 12645             


Gly Ser   Asn Ile Thr Asn Tyr   Ile Val Glu Lys Cys   Asp Val Ser 
    12650                 12655                 12660             


Arg Gly   Asp Trp Val Thr Ala   Leu Ala Ser Val Thr   Lys Thr Ser 
    12665                 12670                 12675             


Cys Arg   Val Gly Lys Leu Ile   Pro Gly Gln Glu Tyr   Ile Phe Arg 
    12680                 12685                 12690             


Val Arg   Ala Glu Asn Arg Phe   Gly Ile Ser Glu Pro   Leu Thr Ser 
    12695                 12700                 12705             


Pro Lys   Met Val Ala Gln Phe   Pro Phe Gly Val Pro   Ser Glu Pro 
    12710                 12715                 12720             


Lys Asn   Ala Arg Val Thr Lys   Val Asn Lys Asp Cys   Ile Phe Val 
    12725                 12730                 12735             


Ala Trp   Asp Arg Pro Asp Ser   Asp Gly Gly Ser Pro   Ile Ile Gly 
    12740                 12745                 12750             


Tyr Leu   Ile Glu Arg Lys Glu   Arg Asn Ser Leu Leu   Trp Val Lys 
    12755                 12760                 12765             


Ala Asn   Asp Thr Leu Val Arg   Ser Thr Glu Tyr Pro   Cys Ala Gly 
    12770                 12775                 12780             


Leu Val   Glu Gly Leu Glu Tyr   Ser Phe Arg Ile Tyr   Ala Leu Asn 
    12785                 12790                 12795             


Lys Ala   Gly Ser Ser Pro Pro   Ser Lys Pro Thr Glu   Tyr Val Thr 
    12800                 12805                 12810             


Ala Arg   Met Pro Val Asp Pro   Pro Gly Lys Pro Glu   Val Ile Asp 
    12815                 12820                 12825             


Val Thr   Lys Ser Thr Val Ser   Leu Ile Trp Ala Arg   Pro Lys His 
    12830                 12835                 12840             


Asp Gly   Gly Ser Lys Ile Ile   Gly Tyr Phe Val Glu   Ala Cys Lys 
    12845                 12850                 12855             


Leu Pro   Gly Asp Lys Trp Val   Arg Cys Asn Thr Ala   Pro His Gln 
    12860                 12865                 12870             


Ile Pro   Gln Glu Glu Tyr Thr   Ala Thr Gly Leu Glu   Glu Lys Ala 
    12875                 12880                 12885             


Gln Tyr   Gln Phe Arg Ala Ile   Ala Arg Thr Ala Val   Asn Ile Ser 
    12890                 12895                 12900             


Pro Pro   Ser Glu Pro Ser Asp   Pro Val Thr Ile Leu   Ala Glu Asn 
    12905                 12910                 12915             


Val Pro   Pro Arg Ile Asp Leu   Ser Val Ala Met Lys   Ser Leu Leu 
    12920                 12925                 12930             


Thr Val   Lys Ala Gly Thr Asn   Val Cys Leu Asp Ala   Thr Val Phe 
    12935                 12940                 12945             


Gly Lys   Pro Met Pro Thr Val   Ser Trp Lys Lys Asp   Gly Thr Leu 
    12950                 12955                 12960             


Leu Lys   Pro Ala Glu Gly Ile   Lys Met Ala Met Gln   Arg Asn Leu 
    12965                 12970                 12975             


Cys Thr   Leu Glu Leu Phe Ser   Val Asn Arg Lys Asp   Ser Gly Asp 
    12980                 12985                 12990             


Tyr Thr   Ile Thr Ala Glu Asn   Ser Ser Gly Ser Lys   Ser Ala Thr 
    12995                 13000                 13005             


Ile Lys   Leu Lys Val Leu Asp   Lys Pro Gly Pro Pro   Ala Ser Val 
    13010                 13015                 13020             


Lys Ile   Asn Lys Met Tyr Ser   Asp Arg Ala Met Leu   Ser Trp Glu 
    13025                 13030                 13035             


Pro Pro   Leu Glu Asp Gly Gly   Ser Glu Ile Thr Asn   Tyr Ile Val 
    13040                 13045                 13050             


Asp Lys   Arg Glu Thr Ser Arg   Pro Asn Trp Ala Gln   Val Ser Ala 
    13055                 13060                 13065             


Thr Val   Pro Ile Thr Ser Cys   Ser Val Glu Lys Leu   Ile Glu Gly 
    13070                 13075                 13080             


His Glu   Tyr Gln Phe Arg Ile   Cys Ala Glu Asn Lys   Tyr Gly Val 
    13085                 13090                 13095             


Gly Asp   Pro Val Phe Thr Glu   Pro Ala Ile Ala Lys   Asn Pro Tyr 
    13100                 13105                 13110             


Asp Pro   Pro Gly Arg Cys Asp   Pro Pro Val Ile Ser   Asn Ile Thr 
    13115                 13120                 13125             


Lys Asp   His Met Thr Val Ser   Trp Lys Pro Pro Ala   Asp Asp Gly 
    13130                 13135                 13140             


Gly Ser   Pro Ile Thr Gly Tyr   Leu Leu Glu Lys Arg   Glu Thr Gln 
    13145                 13150                 13155             


Ala Val   Asn Trp Thr Lys Val   Asn Arg Lys Pro Ile   Ile Glu Arg 
    13160                 13165                 13170             


Thr Leu   Lys Ala Thr Gly Leu   Gln Glu Gly Thr Glu   Tyr Glu Phe 
    13175                 13180                 13185             


Arg Val   Thr Ala Ile Asn Lys   Ala Gly Pro Gly Lys   Pro Ser Asp 
    13190                 13195                 13200             


Ala Ser   Lys Ala Ala Tyr Ala   Arg Asp Pro Gln Tyr   Pro Pro Ala 
    13205                 13210                 13215             


Pro Pro   Ala Phe Pro Lys Val   Tyr Asp Thr Thr Arg   Ser Ser Val 
    13220                 13225                 13230             


Ser Leu   Ser Trp Gly Lys Pro   Ala Tyr Asp Gly Gly   Ser Pro Ile 
    13235                 13240                 13245             


Ile Gly   Tyr Leu Val Glu Val   Lys Arg Ala Asp Ser   Asp Asn Trp 
    13250                 13255                 13260             


Val Arg   Cys Asn Leu Pro Gln   Asn Leu Gln Lys Thr   Arg Phe Glu 
    13265                 13270                 13275             


Val Thr   Gly Leu Met Glu Asp   Thr Gln Tyr Gln Phe   Arg Val Tyr 
    13280                 13285                 13290             


Ala Val   Asn Lys Ile Gly Tyr   Ser Asp Pro Ser Asp   Val Pro Asp 
    13295                 13300                 13305             


Lys His   Tyr Pro Lys Asp Ile   Leu Ile Pro Pro Glu   Gly Glu Leu 
    13310                 13315                 13320             


Asp Ala   Asp Leu Arg Lys Thr   Leu Ile Leu Arg Ala   Gly Val Thr 
    13325                 13330                 13335             


Met Arg   Leu Tyr Val Pro Val   Lys Gly Arg Pro Pro   Pro Lys Ile 
    13340                 13345                 13350             


Thr Trp   Ser Lys Pro Asn Val   Asn Leu Arg Asp Arg   Ile Gly Leu 
    13355                 13360                 13365             


Asp Ile   Lys Ser Thr Asp Phe   Asp Thr Phe Leu Arg   Cys Glu Asn 
    13370                 13375                 13380             


Val Asn   Lys Tyr Asp Ala Gly   Lys Tyr Ile Leu Thr   Leu Glu Asn 
    13385                 13390                 13395             


Ser Cys   Gly Lys Lys Glu Tyr   Thr Ile Val Val Lys   Val Leu Asp 
    13400                 13405                 13410             


Thr Pro   Gly Pro Pro Val Asn   Val Thr Val Lys Glu   Ile Ser Lys 
    13415                 13420                 13425             


Asp Ser   Ala Tyr Val Thr Trp   Glu Pro Pro Ile Ile   Asp Gly Gly 
    13430                 13435                 13440             


Ser Pro   Ile Ile Asn Tyr Val   Val Gln Lys Arg Asp   Ala Glu Arg 
    13445                 13450                 13455             


Lys Ser   Trp Ser Thr Val Thr   Thr Glu Cys Ser Lys   Thr Ser Phe 
    13460                 13465                 13470             


Arg Val   Ala Asn Leu Glu Glu   Gly Lys Ser Tyr Phe   Phe Arg Val 
    13475                 13480                 13485             


Phe Ala   Glu Asn Glu Tyr Gly   Ile Gly Asp Pro Gly   Glu Thr Arg 
    13490                 13495                 13500             


Asp Ala   Val Lys Ala Ser Gln   Thr Pro Gly Pro Val   Val Asp Leu 
    13505                 13510                 13515             


Lys Val   Arg Ser Val Ser Lys   Ser Ser Cys Ser Ile   Gly Trp Lys 
    13520                 13525                 13530             


Lys Pro   His Ser Asp Gly Gly   Ser Arg Ile Ile Gly   Tyr Val Val 
    13535                 13540                 13545             


Asp Phe   Leu Thr Glu Glu Asn   Lys Trp Gln Arg Val   Met Lys Ser 
    13550                 13555                 13560             


Leu Ser   Leu Gln Tyr Ser Ala   Lys Asp Leu Thr Glu   Gly Lys Glu 
    13565                 13570                 13575             


Tyr Thr   Phe Arg Val Ser Ala   Glu Asn Glu Asn Gly   Glu Gly Thr 
    13580                 13585                 13590             


Pro Ser   Glu Ile Thr Val Val   Ala Arg Asp Asp Val   Val Ala Pro 
    13595                 13600                 13605             


Asp Leu   Asp Leu Lys Gly Leu   Pro Asp Leu Cys Tyr   Leu Ala Lys 
    13610                 13615                 13620             


Glu Asn   Ser Asn Phe Arg Leu   Lys Ile Pro Ile Lys   Gly Lys Pro 
    13625                 13630                 13635             


Ala Pro   Ser Val Ser Trp Lys   Lys Gly Glu Asp Pro   Leu Ala Thr 
    13640                 13645                 13650             


Asp Thr   Arg Val Ser Val Glu   Ser Ser Ala Val Asn   Thr Thr Leu 
    13655                 13660                 13665             


Ile Val   Tyr Asp Cys Gln Lys   Ser Asp Ala Gly Lys   Tyr Thr Ile 
    13670                 13675                 13680             


Thr Leu   Lys Asn Val Ala Gly   Thr Lys Glu Gly Thr   Ile Ser Ile 
    13685                 13690                 13695             


Lys Val   Val Gly Lys Pro Gly   Ile Pro Thr Gly Pro   Ile Lys Phe 
    13700                 13705                 13710             


Asp Glu   Val Thr Ala Glu Ala   Met Thr Leu Lys Trp   Ala Pro Pro 
    13715                 13720                 13725             


Lys Asp   Asp Gly Gly Ser Glu   Ile Thr Asn Tyr Ile   Leu Glu Lys 
    13730                 13735                 13740             


Arg Asp   Ser Val Asn Asn Lys   Trp Val Thr Cys Ala   Ser Ala Val 
    13745                 13750                 13755             


Gln Lys   Thr Thr Phe Arg Val   Thr Arg Leu His Glu   Gly Met Glu 
    13760                 13765                 13770             


Tyr Thr   Phe Arg Val Ser Ala   Glu Asn Lys Tyr Gly   Val Gly Glu 
    13775                 13780                 13785             


Gly Leu   Lys Ser Glu Pro Ile   Val Ala Arg His Pro   Phe Asp Val 
    13790                 13795                 13800             


Pro Asp   Ala Pro Pro Pro Pro   Asn Ile Val Asp Val   Arg His Asp 
    13805                 13810                 13815             


Ser Val   Ser Leu Thr Trp Thr   Asp Pro Lys Lys Thr   Gly Gly Ser 
    13820                 13825                 13830             


Pro Ile   Thr Gly Tyr His Leu   Glu Phe Lys Glu Arg   Asn Ser Leu 
    13835                 13840                 13845             


Leu Trp   Lys Arg Ala Asn Lys   Thr Pro Ile Arg Met   Arg Asp Phe 
    13850                 13855                 13860             


Lys Val   Thr Gly Leu Thr Glu   Gly Leu Glu Tyr Glu   Phe Arg Val 
    13865                 13870                 13875             


Met Ala   Ile Asn Leu Ala Gly   Val Gly Lys Pro Ser   Leu Pro Ser 
    13880                 13885                 13890             


Glu Pro   Val Val Ala Leu Asp   Pro Ile Asp Pro Pro   Gly Lys Pro 
    13895                 13900                 13905             


Glu Val   Ile Asn Ile Thr Arg   Asn Ser Val Thr Leu   Ile Trp Thr 
    13910                 13915                 13920             


Glu Pro   Lys Tyr Asp Gly Gly   His Lys Leu Thr Gly   Tyr Ile Val 
    13925                 13930                 13935             


Glu Lys   Arg Asp Leu Pro Ser   Lys Ser Trp Met Lys   Ala Asn His 
    13940                 13945                 13950             


Val Asn   Val Pro Glu Cys Ala   Phe Thr Val Thr Asp   Leu Val Glu 
    13955                 13960                 13965             


Gly Gly   Lys Tyr Glu Phe Arg   Ile Arg Ala Lys Asn   Thr Ala Gly 
    13970                 13975                 13980             


Ala Ile   Ser Ala Pro Ser Glu   Ser Thr Glu Thr Ile   Ile Cys Lys 
    13985                 13990                 13995             


Asp Glu   Tyr Glu Ala Pro Thr   Ile Val Leu Asp Pro   Thr Ile Lys 
    14000                 14005                 14010             


Asp Gly   Leu Thr Ile Lys Ala   Gly Asp Thr Ile Val   Leu Asn Ala 
    14015                 14020                 14025             


Ile Ser   Ile Leu Gly Lys Pro   Leu Pro Lys Ser Ser   Trp Ser Lys 
    14030                 14035                 14040             


Ala Gly   Lys Asp Ile Arg Pro   Ser Asp Ile Thr Gln   Ile Thr Ser 
    14045                 14050                 14055             


Thr Pro   Thr Ser Ser Met Leu   Thr Ile Lys Tyr Ala   Thr Arg Lys 
    14060                 14065                 14070             


Asp Ala   Gly Glu Tyr Thr Ile   Thr Ala Thr Asn Pro   Phe Gly Thr 
    14075                 14080                 14085             


Lys Val   Glu His Val Lys Val   Thr Val Leu Asp Val   Pro Gly Pro 
    14090                 14095                 14100             


Pro Gly   Pro Val Glu Ile Ser   Asn Val Ser Ala Glu   Lys Ala Thr 
    14105                 14110                 14115             


Leu Thr   Trp Thr Pro Pro Leu   Glu Asp Gly Gly Ser   Pro Ile Lys 
    14120                 14125                 14130             


Ser Tyr   Ile Leu Glu Lys Arg   Glu Thr Ser Arg Leu   Leu Trp Thr 
    14135                 14140                 14145             


Val Val   Ser Glu Asp Ile Gln   Ser Cys Arg His Val   Ala Thr Lys 
    14150                 14155                 14160             


Leu Ile   Gln Gly Asn Glu Tyr   Ile Phe Arg Val Ser   Ala Val Asn 
    14165                 14170                 14175             


His Tyr   Gly Lys Gly Glu Pro   Val Gln Ser Glu Pro   Val Lys Met 
    14180                 14185                 14190             


Val Asp   Arg Phe Gly Pro Pro   Gly Pro Pro Glu Lys   Pro Glu Val 
    14195                 14200                 14205             


Ser Asn   Val Thr Lys Asn Thr   Ala Thr Val Ser Trp   Lys Arg Pro 
    14210                 14215                 14220             


Val Asp   Asp Gly Gly Ser Glu   Ile Thr Gly Tyr His   Val Glu Arg 
    14225                 14230                 14235             


Arg Glu   Lys Lys Ser Leu Arg   Trp Val Arg Ala Ile   Lys Thr Pro 
    14240                 14245                 14250             


Val Ser   Asp Leu Arg Cys Lys   Val Thr Gly Leu Gln   Glu Gly Ser 
    14255                 14260                 14265             


Thr Tyr   Glu Phe Arg Val Ser   Ala Glu Asn Arg Ala   Gly Ile Gly 
    14270                 14275                 14280             


Pro Pro   Ser Glu Ala Ser Asp   Ser Val Leu Met Lys   Asp Ala Ala 
    14285                 14290                 14295             


Tyr Pro   Pro Gly Pro Pro Ser   Asn Pro His Val Thr   Asp Thr Thr 
    14300                 14305                 14310             


Lys Lys   Ser Ala Ser Leu Ala   Trp Gly Lys Pro His   Tyr Asp Gly 
    14315                 14320                 14325             


Gly Leu   Glu Ile Thr Gly Tyr   Val Val Glu His Gln   Lys Val Gly 
    14330                 14335                 14340             


Asp Glu   Ala Trp Ile Lys Asp   Thr Thr Gly Thr Ala   Leu Arg Ile 
    14345                 14350                 14355             


Thr Gln   Phe Val Val Pro Asp   Leu Gln Thr Lys Glu   Lys Tyr Asn 
    14360                 14365                 14370             


Phe Arg   Ile Ser Ala Ile Asn   Asp Ala Gly Val Gly   Glu Pro Ala 
    14375                 14380                 14385             


Val Ile   Pro Asp Val Glu Ile   Val Glu Arg Glu Met   Ala Pro Asp 
    14390                 14395                 14400             


Phe Glu   Leu Asp Ala Glu Leu   Arg Arg Thr Leu Val   Val Arg Ala 
    14405                 14410                 14415             


Gly Leu   Ser Ile Arg Ile Phe   Val Pro Ile Lys Gly   Arg Pro Ala 
    14420                 14425                 14430             


Pro Glu   Val Thr Trp Thr Lys   Asp Asn Ile Asn Leu   Lys Asn Arg 
    14435                 14440                 14445             


Ala Asn   Ile Glu Asn Thr Glu   Ser Phe Thr Leu Leu   Ile Ile Pro 
    14450                 14455                 14460             


Glu Cys   Asn Arg Tyr Asp Thr   Gly Lys Phe Val Met   Thr Ile Glu 
    14465                 14470                 14475             


Asn Pro   Ala Gly Lys Lys Ser   Gly Phe Val Asn Val   Arg Val Leu 
    14480                 14485                 14490             


Asp Thr   Pro Gly Pro Val Leu   Asn Leu Arg Pro Thr   Asp Ile Thr 
    14495                 14500                 14505             


Lys Asp   Ser Val Thr Leu His   Trp Asp Leu Pro Leu   Ile Asp Gly 
    14510                 14515                 14520             


Gly Ser   Arg Ile Thr Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Thr 
    14525                 14530                 14535             


Arg Lys   Ser Tyr Ser Thr Ala   Thr Thr Lys Cys His   Lys Cys Thr 
    14540                 14545                 14550             


Tyr Lys   Val Thr Gly Leu Ser   Glu Gly Cys Glu Tyr   Phe Phe Arg 
    14555                 14560                 14565             


Val Met   Ala Glu Asn Glu Tyr   Gly Ile Gly Glu Pro   Thr Glu Thr 
    14570                 14575                 14580             


Thr Glu   Pro Val Lys Ala Ser   Glu Ala Pro Ser Pro   Pro Asp Ser 
    14585                 14590                 14595             


Leu Asn   Ile Met Asp Ile Thr   Lys Ser Thr Val Ser   Leu Ala Trp 
    14600                 14605                 14610             


Pro Lys   Pro Lys His Asp Gly   Gly Ser Lys Ile Thr   Gly Tyr Val 
    14615                 14620                 14625             


Ile Glu   Ala Gln Arg Lys Gly   Ser Asp Gln Trp Thr   His Ile Thr 
    14630                 14635                 14640             


Thr Val   Lys Gly Leu Glu Cys   Val Val Arg Asn Leu   Thr Glu Gly 
    14645                 14650                 14655             


Glu Glu   Tyr Thr Phe Gln Val   Met Ala Val Asn Ser   Ala Gly Arg 
    14660                 14665                 14670             


Ser Ala   Pro Arg Glu Ser Arg   Pro Val Ile Val Lys   Glu Gln Thr 
    14675                 14680                 14685             


Met Leu   Pro Glu Leu Asp Leu   Arg Gly Ile Tyr Gln   Lys Leu Val 
    14690                 14695                 14700             


Ile Ala   Lys Ala Gly Asp Asn   Ile Lys Val Glu Ile   Pro Val Leu 
    14705                 14710                 14715             


Gly Arg   Pro Lys Pro Thr Val   Thr Trp Lys Lys Gly   Asp Gln Ile 
    14720                 14725                 14730             


Leu Lys   Gln Thr Gln Arg Val   Asn Phe Glu Thr Thr   Ala Thr Ser 
    14735                 14740                 14745             


Thr Ile   Leu Asn Ile Asn Glu   Cys Val Arg Ser Asp   Ser Gly Pro 
    14750                 14755                 14760             


Tyr Pro   Leu Thr Ala Arg Asn   Ile Val Gly Glu Val   Gly Asp Val 
    14765                 14770                 14775             


Ile Thr   Ile Gln Val His Asp   Ile Pro Gly Pro Pro   Thr Gly Pro 
    14780                 14785                 14790             


Ile Lys   Phe Asp Glu Val Ser   Ser Asp Phe Val Thr   Phe Ser Trp 
    14795                 14800                 14805             


Asp Pro   Pro Glu Asn Asp Gly   Gly Val Pro Ile Ser   Asn Tyr Val 
    14810                 14815                 14820             


Val Glu   Met Arg Gln Thr Asp   Ser Thr Thr Trp Val   Glu Leu Ala 
    14825                 14830                 14835             


Thr Thr   Val Ile Arg Thr Thr   Tyr Lys Ala Thr Arg   Leu Thr Thr 
    14840                 14845                 14850             


Gly Leu   Glu Tyr Gln Phe Arg   Val Lys Ala Gln Asn   Arg Tyr Gly 
    14855                 14860                 14865             


Val Gly   Pro Gly Ile Thr Ser   Ala Cys Ile Val Ala   Asn Tyr Pro 
    14870                 14875                 14880             


Phe Lys   Val Pro Gly Pro Pro   Gly Thr Pro Gln Val   Thr Ala Val 
    14885                 14890                 14895             


Thr Lys   Asp Ser Met Thr Ile   Ser Trp His Glu Pro   Leu Ser Asp 
    14900                 14905                 14910             


Gly Gly   Ser Pro Ile Leu Gly   Tyr His Val Glu Arg   Lys Glu Arg 
    14915                 14920                 14925             


Asn Gly   Ile Leu Trp Gln Thr   Val Ser Lys Ala Leu   Val Pro Gly 
    14930                 14935                 14940             


Asn Ile   Phe Lys Ser Ser Gly   Leu Thr Asp Gly Ile   Ala Tyr Glu 
    14945                 14950                 14955             


Phe Arg   Val Ile Ala Glu Asn   Met Ala Gly Lys Ser   Lys Pro Ser 
    14960                 14965                 14970             


Lys Pro   Ser Glu Pro Met Leu   Ala Leu Asp Pro Ile   Asp Pro Pro 
    14975                 14980                 14985             


Gly Lys   Pro Val Pro Leu Asn   Ile Thr Arg His Thr   Val Thr Leu 
    14990                 14995                 15000             


Lys Trp   Ala Lys Pro Glu Tyr   Thr Gly Gly Phe Lys   Ile Thr Ser 
    15005                 15010                 15015             


Tyr Ile   Val Glu Lys Arg Asp   Leu Pro Asn Gly Arg   Trp Leu Lys 
    15020                 15025                 15030             


Ala Asn   Phe Ser Asn Ile Leu   Glu Asn Glu Phe Thr   Val Ser Gly 
    15035                 15040                 15045             


Leu Thr   Glu Asp Ala Ala Tyr   Glu Phe Arg Val Ile   Ala Lys Asn 
    15050                 15055                 15060             


Ala Ala   Gly Ala Ile Ser Pro   Pro Ser Glu Pro Ser   Asp Ala Ile 
    15065                 15070                 15075             


Thr Cys   Arg Asp Asp Val Glu   Ala Pro Lys Ile Lys   Val Asp Val 
    15080                 15085                 15090             


Lys Phe   Lys Asp Thr Val Ile   Leu Lys Ala Gly Glu   Ala Phe Arg 
    15095                 15100                 15105             


Leu Glu   Ala Asp Val Ser Gly   Arg Pro Pro Pro Thr   Met Glu Trp 
    15110                 15115                 15120             


Ser Lys   Asp Gly Lys Glu Leu   Glu Gly Thr Ala Lys   Leu Glu Ile 
    15125                 15130                 15135             


Lys Ile   Ala Asp Phe Ser Thr   Asn Leu Val Asn Lys   Asp Ser Thr 
    15140                 15145                 15150             


Arg Arg   Asp Ser Gly Ala Tyr   Thr Leu Thr Ala Thr   Asn Pro Gly 
    15155                 15160                 15165             


Gly Phe   Ala Lys His Ile Phe   Asn Val Lys Val Leu   Asp Arg Pro 
    15170                 15175                 15180             


Gly Pro   Pro Glu Gly Pro Leu   Ala Val Thr Glu Val   Thr Ser Glu 
    15185                 15190                 15195             


Lys Cys   Val Leu Ser Trp Phe   Pro Pro Leu Asp Asp   Gly Gly Ala 
    15200                 15205                 15210             


Lys Ile   Asp His Tyr Ile Val   Gln Lys Arg Glu Thr   Ser Arg Leu 
    15215                 15220                 15225             


Ala Trp   Thr Asn Val Ala Ser   Glu Val Gln Val Thr   Lys Leu Lys 
    15230                 15235                 15240             


Val Thr   Lys Leu Leu Lys Gly   Asn Glu Tyr Ile Phe   Arg Val Met 
    15245                 15250                 15255             


Ala Val   Asn Lys Tyr Gly Val   Gly Glu Pro Leu Glu   Ser Glu Pro 
    15260                 15265                 15270             


Val Leu   Ala Val Asn Pro Tyr   Gly Pro Pro Asp Pro   Pro Lys Asn 
    15275                 15280                 15285             


Pro Glu   Val Thr Thr Ile Thr   Lys Asp Ser Met Val   Val Cys Trp 
    15290                 15295                 15300             


Gly His   Pro Asp Ser Asp Gly   Gly Ser Glu Ile Ile   Asn Tyr Ile 
    15305                 15310                 15315             


Val Glu   Arg Arg Asp Lys Ala   Gly Gln Arg Trp Ile   Lys Cys Asn 
    15320                 15325                 15330             


Lys Lys   Thr Leu Thr Asp Leu   Arg Tyr Lys Val Ser   Gly Leu Thr 
    15335                 15340                 15345             


Glu Gly   His Glu Tyr Glu Phe   Arg Ile Met Ala Glu   Asn Ala Ala 
    15350                 15355                 15360             


Gly Ile   Ser Ala Pro Ser Pro   Thr Ser Pro Phe Tyr   Lys Ala Cys 
    15365                 15370                 15375             


Asp Thr   Val Phe Lys Pro Gly   Pro Pro Gly Asn Pro   Arg Val Leu 
    15380                 15385                 15390             


Asp Thr   Ser Arg Ser Ser Ile   Ser Ile Ala Trp Asn   Lys Pro Ile 
    15395                 15400                 15405             


Tyr Asp   Gly Gly Ser Glu Ile   Thr Gly Tyr Met Val   Glu Ile Ala 
    15410                 15415                 15420             


Leu Pro   Glu Glu Asp Glu Trp   Gln Ile Val Thr Pro   Pro Ala Gly 
    15425                 15430                 15435             


Leu Lys   Ala Thr Ser Tyr Thr   Ile Thr Gly Leu Thr   Glu Asn Gln 
    15440                 15445                 15450             


Glu Tyr   Lys Ile Arg Ile Tyr   Ala Met Asn Ser Glu   Gly Leu Gly 
    15455                 15460                 15465             


Glu Pro   Ala Leu Val Pro Gly   Thr Pro Lys Ala Glu   Asp Arg Met 
    15470                 15475                 15480             


Leu Pro   Pro Glu Ile Glu Leu   Asp Ala Asp Leu Arg   Lys Val Val 
    15485                 15490                 15495             


Thr Ile   Arg Ala Cys Cys Thr   Leu Arg Leu Phe Val   Pro Ile Lys 
    15500                 15505                 15510             


Gly Arg   Pro Ala Pro Glu Val   Lys Trp Ala Arg Asp   His Gly Glu 
    15515                 15520                 15525             


Ser Leu   Asp Lys Ala Ser Ile   Glu Ser Thr Ser Ser   Tyr Thr Leu 
    15530                 15535                 15540             


Leu Ile   Val Gly Asn Val Asn   Arg Phe Asp Ser Gly   Lys Tyr Ile 
    15545                 15550                 15555             


Leu Thr   Val Glu Asn Ser Ser   Gly Ser Lys Ser Ala   Phe Val Asn 
    15560                 15565                 15570             


Val Arg   Val Leu Asp Thr Pro   Gly Pro Pro Gln Asp   Leu Lys Val 
    15575                 15580                 15585             


Lys Glu   Val Thr Lys Thr Ser   Val Thr Leu Thr Trp   Asp Pro Pro 
    15590                 15595                 15600             


Leu Leu   Asp Gly Gly Ser Lys   Ile Lys Asn Tyr Ile   Val Glu Lys 
    15605                 15610                 15615             


Arg Glu   Ser Thr Arg Lys Ala   Tyr Ser Thr Val Ala   Thr Asn Cys 
    15620                 15625                 15630             


His Lys   Thr Ser Trp Lys Val   Asp Gln Leu Gln Glu   Gly Cys Ser 
    15635                 15640                 15645             


Tyr Tyr   Phe Arg Val Leu Ala   Glu Asn Glu Tyr Gly   Ile Gly Leu 
    15650                 15655                 15660             


Pro Ala   Glu Thr Ala Glu Ser   Val Lys Ala Ser Glu   Arg Pro Leu 
    15665                 15670                 15675             


Pro Pro   Gly Lys Ile Thr Leu   Met Asp Val Thr Arg   Asn Ser Val 
    15680                 15685                 15690             


Ser Leu   Ser Trp Glu Lys Pro   Glu His Asp Gly Gly   Ser Arg Ile 
    15695                 15700                 15705             


Leu Gly   Tyr Ile Val Glu Met   Gln Thr Lys Gly Ser   Asp Lys Trp 
    15710                 15715                 15720             


Ala Thr   Cys Ala Thr Val Lys   Val Thr Glu Ala Thr   Ile Thr Gly 
    15725                 15730                 15735             


Leu Ile   Gln Gly Glu Glu Tyr   Ser Phe Arg Val Ser   Ala Gln Asn 
    15740                 15745                 15750             


Glu Lys   Gly Ile Ser Asp Pro   Arg Gln Leu Ser Val   Pro Val Ile 
    15755                 15760                 15765             


Ala Lys   Asp Leu Val Ile Pro   Pro Ala Phe Lys Leu   Leu Phe Asn 
    15770                 15775                 15780             


Thr Phe   Thr Val Leu Ala Gly   Glu Asp Leu Lys Val   Asp Val Pro 
    15785                 15790                 15795             


Phe Ile   Gly Arg Pro Thr Pro   Ala Val Thr Trp His   Lys Asp Asn 
    15800                 15805                 15810             


Val Pro   Leu Lys Gln Thr Thr   Arg Val Asn Ala Glu   Ser Thr Glu 
    15815                 15820                 15825             


Asn Asn   Ser Leu Leu Thr Ile   Lys Asp Ala Cys Arg   Glu Asp Val 
    15830                 15835                 15840             


Gly His   Tyr Val Val Lys Leu   Thr Asn Ser Ala Gly   Glu Ala Ile 
    15845                 15850                 15855             


Glu Thr   Leu Asn Val Ile Val   Leu Asp Lys Pro Gly   Pro Pro Thr 
    15860                 15865                 15870             


Gly Pro   Val Lys Met Asp Glu   Val Thr Ala Asp Ser   Ile Thr Leu 
    15875                 15880                 15885             


Ser Trp   Gly Pro Pro Lys Tyr   Asp Gly Gly Ser Ser   Ile Asn Asn 
    15890                 15895                 15900             


Tyr Ile   Val Glu Lys Arg Asp   Thr Ser Thr Thr Thr   Trp Gln Ile 
    15905                 15910                 15915             


Val Ser   Ala Thr Val Ala Arg   Thr Thr Ile Lys Ala   Cys Arg Leu 
    15920                 15925                 15930             


Lys Thr   Gly Cys Glu Tyr Gln   Phe Arg Ile Ala Ala   Glu Asn Arg 
    15935                 15940                 15945             


Tyr Gly   Lys Ser Thr Tyr Leu   Asn Ser Glu Pro Thr   Val Ala Gln 
    15950                 15955                 15960             


Tyr Pro   Phe Lys Val Pro Gly   Pro Pro Gly Thr Pro   Val Val Thr 
    15965                 15970                 15975             


Leu Ser   Ser Arg Asp Ser Met   Glu Val Gln Trp Asn   Glu Pro Ile 
    15980                 15985                 15990             


Ser Asp   Gly Gly Ser Arg Val   Ile Gly Tyr His Leu   Glu Arg Lys 
    15995                 16000                 16005             


Glu Arg   Asn Ser Ile Leu Trp   Val Lys Leu Asn Lys   Thr Pro Ile 
    16010                 16015                 16020             


Pro Gln   Thr Lys Phe Lys Thr   Thr Gly Leu Glu Glu   Gly Val Glu 
    16025                 16030                 16035             


Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Ile Val Gly   Ile Gly Lys 
    16040                 16045                 16050             


Pro Ser   Lys Val Ser Glu Cys   Tyr Val Ala Arg Asp   Pro Cys Asp 
    16055                 16060                 16065             


Pro Pro   Gly Arg Pro Glu Ala   Ile Ile Val Thr Arg   Asn Ser Val 
    16070                 16075                 16080             


Thr Leu   Gln Trp Lys Lys Pro   Thr Tyr Asp Gly Gly   Ser Lys Ile 
    16085                 16090                 16095             


Thr Gly   Tyr Ile Val Glu Lys   Lys Glu Leu Pro Glu   Gly Arg Trp 
    16100                 16105                 16110             


Met Lys   Ala Ser Phe Thr Asn   Ile Ile Asp Thr His   Phe Glu Val 
    16115                 16120                 16125             


Thr Gly   Leu Val Glu Asp His   Arg Tyr Glu Phe Arg   Val Ile Ala 
    16130                 16135                 16140             


Arg Asn   Ala Ala Gly Val Phe   Ser Glu Pro Ser Glu   Ser Thr Gly 
    16145                 16150                 16155             


Ala Ile   Thr Ala Arg Asp Glu   Val Asp Pro Pro Arg   Ile Ser Met 
    16160                 16165                 16170             


Asp Pro   Lys Tyr Lys Asp Thr   Ile Val Val His Ala   Gly Glu Ser 
    16175                 16180                 16185             


Phe Lys   Val Asp Ala Asp Ile   Tyr Gly Lys Pro Ile   Pro Thr Ile 
    16190                 16195                 16200             


Gln Trp   Ile Lys Gly Asp Gln   Glu Leu Ser Asn Thr   Ala Arg Leu 
    16205                 16210                 16215             


Glu Ile   Lys Ser Thr Asp Phe   Ala Thr Ser Leu Ser   Val Lys Asp 
    16220                 16225                 16230             


Ala Val   Arg Val Asp Ser Gly   Asn Tyr Ile Leu Lys   Ala Lys Asn 
    16235                 16240                 16245             


Val Ala   Gly Glu Arg Ser Val   Thr Val Asn Val Lys   Val Leu Asp 
    16250                 16255                 16260             


Arg Pro   Gly Pro Pro Glu Gly   Pro Val Val Ile Ser   Gly Val Thr 
    16265                 16270                 16275             


Ala Glu   Lys Cys Thr Leu Ala   Trp Lys Pro Pro Leu   Gln Asp Gly 
    16280                 16285                 16290             


Gly Ser   Asp Ile Ile Asn Tyr   Ile Val Glu Arg Arg   Glu Thr Ser 
    16295                 16300                 16305             


Arg Leu   Val Trp Thr Val Val   Asp Ala Asn Val Gln   Thr Leu Ser 
    16310                 16315                 16320             


Cys Lys   Val Thr Lys Leu Leu   Glu Gly Asn Glu Tyr   Thr Phe Arg 
    16325                 16330                 16335             


Ile Met   Ala Val Asn Lys Tyr   Gly Val Gly Glu Pro   Leu Glu Ser 
    16340                 16345                 16350             


Glu Pro   Val Val Ala Lys Asn   Pro Phe Val Val Pro   Asp Ala Pro 
    16355                 16360                 16365             


Lys Ala   Pro Glu Val Thr Thr   Val Thr Lys Asp Ser   Met Ile Val 
    16370                 16375                 16380             


Val Trp   Glu Arg Pro Ala Ser   Asp Gly Gly Ser Glu   Ile Leu Gly 
    16385                 16390                 16395             


Tyr Val   Leu Glu Lys Arg Asp   Lys Glu Gly Ile Arg   Trp Thr Arg 
    16400                 16405                 16410             


Cys His   Lys Arg Leu Ile Gly   Glu Leu Arg Leu Arg   Val Thr Gly 
    16415                 16420                 16425             


Leu Ile   Glu Asn His Asp Tyr   Glu Phe Arg Val Ser   Ala Glu Asn 
    16430                 16435                 16440             


Ala Ala   Gly Leu Ser Glu Pro   Ser Pro Pro Ser Ala   Tyr Gln Lys 
    16445                 16450                 16455             


Ala Cys   Asp Pro Ile Tyr Lys   Pro Gly Pro Pro Asn   Asn Pro Lys 
    16460                 16465                 16470             


Val Ile   Asp Ile Thr Arg Ser   Ser Val Phe Leu Ser   Trp Ser Lys 
    16475                 16480                 16485             


Pro Ile   Tyr Asp Gly Gly Cys   Glu Ile Gln Gly Tyr   Ile Val Glu 
    16490                 16495                 16500             


Lys Cys   Asp Val Ser Val Gly   Glu Trp Thr Met Cys   Thr Pro Pro 
    16505                 16510                 16515             


Thr Gly   Ile Asn Lys Thr Asn   Ile Glu Val Glu Lys   Leu Leu Glu 
    16520                 16525                 16530             


Lys His   Glu Tyr Asn Phe Arg   Ile Cys Ala Ile Asn   Lys Ala Gly 
    16535                 16540                 16545             


Val Gly   Glu His Ala Asp Val   Pro Gly Pro Ile Ile   Val Glu Glu 
    16550                 16555                 16560             


Lys Leu   Glu Ala Pro Asp Ile   Asp Leu Asp Leu Glu   Leu Arg Lys 
    16565                 16570                 16575             


Ile Ile   Asn Ile Arg Ala Gly   Gly Ser Leu Arg Leu   Phe Val Pro 
    16580                 16585                 16590             


Ile Lys   Gly Arg Pro Thr Pro   Glu Val Lys Trp Gly   Lys Val Asp 
    16595                 16600                 16605             


Gly Glu   Ile Arg Asp Ala Ala   Ile Ile Asp Val Thr   Ser Ser Phe 
    16610                 16615                 16620             


Thr Ser   Leu Val Leu Asp Asn   Val Asn Arg Tyr Asp   Ser Gly Lys 
    16625                 16630                 16635             


Tyr Thr   Leu Thr Leu Glu Asn   Ser Ser Gly Thr Lys   Ser Ala Phe 
    16640                 16645                 16650             


Val Thr   Val Arg Val Leu Asp   Thr Pro Ser Pro Pro   Val Asn Leu 
    16655                 16660                 16665             


Lys Val   Thr Glu Ile Thr Lys   Asp Ser Val Ser Ile   Thr Trp Glu 
    16670                 16675                 16680             


Pro Pro   Leu Leu Asp Gly Gly   Ser Lys Ile Lys Asn   Tyr Ile Val 
    16685                 16690                 16695             


Glu Lys   Arg Glu Ala Thr Arg   Lys Ser Tyr Ala Ala   Val Val Thr 
    16700                 16705                 16710             


Asn Cys   His Lys Asn Ser Trp   Lys Ile Asp Gln Leu   Gln Glu Gly 
    16715                 16720                 16725             


Cys Ser   Tyr Tyr Phe Arg Val   Thr Ala Glu Asn Glu   Tyr Gly Ile 
    16730                 16735                 16740             


Gly Leu   Pro Ala Gln Thr Ala   Asp Pro Ile Lys Val   Ala Glu Val 
    16745                 16750                 16755             


Pro Gln   Pro Pro Gly Lys Ile   Thr Val Asp Asp Val   Thr Arg Asn 
    16760                 16765                 16770             


Ser Val   Ser Leu Ser Trp Thr   Lys Pro Glu His Asp   Gly Gly Ser 
    16775                 16780                 16785             


Lys Ile   Ile Gln Tyr Ile Val   Glu Met Gln Ala Lys   His Ser Glu 
    16790                 16795                 16800             


Lys Trp   Ser Glu Cys Ala Arg   Val Lys Ser Leu Gln   Ala Val Ile 
    16805                 16810                 16815             


Thr Asn   Leu Thr Gln Gly Glu   Glu Tyr Leu Phe Arg   Val Val Ala 
    16820                 16825                 16830             


Val Asn   Glu Lys Gly Arg Ser   Asp Pro Arg Ser Leu   Ala Val Pro 
    16835                 16840                 16845             


Ile Val   Ala Lys Asp Leu Val   Ile Glu Pro Asp Val   Lys Pro Ala 
    16850                 16855                 16860             


Phe Ser   Ser Tyr Ser Val Gln   Val Gly Gln Asp Leu   Lys Ile Glu 
    16865                 16870                 16875             


Val Pro   Ile Ser Gly Arg Pro   Lys Pro Thr Ile Thr   Trp Thr Lys 
    16880                 16885                 16890             


Asp Gly   Leu Pro Leu Lys Gln   Thr Thr Arg Ile Asn   Val Thr Asp 
    16895                 16900                 16905             


Ser Leu   Asp Leu Thr Thr Leu   Ser Ile Lys Glu Thr   His Lys Asp 
    16910                 16915                 16920             


Asp Gly   Gly Gln Tyr Gly Ile   Thr Val Ala Asn Val   Val Gly Gln 
    16925                 16930                 16935             


Lys Thr   Ala Ser Ile Glu Ile   Val Thr Leu Asp Lys   Pro Asp Pro 
    16940                 16945                 16950             


Pro Lys   Gly Pro Val Lys Phe   Asp Asp Val Ser Ala   Glu Ser Ile 
    16955                 16960                 16965             


Thr Leu   Ser Trp Asn Pro Pro   Leu Tyr Thr Gly Gly   Cys Gln Ile 
    16970                 16975                 16980             


Thr Asn   Tyr Ile Val Gln Lys   Arg Asp Thr Thr Thr   Thr Val Trp 
    16985                 16990                 16995             


Asp Val   Val Ser Ala Thr Val   Ala Arg Thr Thr Leu   Lys Val Thr 
    17000                 17005                 17010             


Lys Leu   Lys Thr Gly Thr Glu   Tyr Gln Phe Arg Ile   Phe Ala Glu 
    17015                 17020                 17025             


Asn Arg   Tyr Gly Gln Ser Phe   Ala Leu Glu Ser Asp   Pro Ile Val 
    17030                 17035                 17040             


Ala Gln   Tyr Pro Tyr Lys Glu   Pro Gly Pro Pro Gly   Thr Pro Phe 
    17045                 17050                 17055             


Ala Thr   Ala Ile Ser Lys Asp   Ser Met Val Ile Gln   Trp His Glu 
    17060                 17065                 17070             


Pro Val   Asn Asn Gly Gly Ser   Pro Val Ile Gly Tyr   His Leu Glu 
    17075                 17080                 17085             


Arg Lys   Glu Arg Asn Ser Ile   Leu Trp Thr Lys Val   Asn Lys Thr 
    17090                 17095                 17100             


Ile Ile   His Asp Thr Gln Phe   Lys Ala Gln Asn Leu   Glu Glu Gly 
    17105                 17110                 17115             


Ile Glu   Tyr Glu Phe Arg Val   Tyr Ala Glu Asn Ile   Val Gly Val 
    17120                 17125                 17130             


Gly Lys   Ala Ser Lys Asn Ser   Glu Cys Tyr Val Ala   Arg Asp Pro 
    17135                 17140                 17145             


Cys Asp   Pro Pro Gly Thr Pro   Glu Pro Ile Met Val   Lys Arg Asn 
    17150                 17155                 17160             


Glu Ile   Thr Leu Gln Trp Thr   Lys Pro Val Tyr Asp   Gly Gly Ser 
    17165                 17170                 17175             


Met Ile   Thr Gly Tyr Ile Val   Glu Lys Arg Asp Leu   Pro Asp Gly 
    17180                 17185                 17190             


Arg Trp   Met Lys Ala Ser Phe   Thr Asn Val Ile Glu   Thr Gln Phe 
    17195                 17200                 17205             


Thr Val   Ser Gly Leu Thr Glu   Asp Gln Arg Tyr Glu   Phe Arg Val 
    17210                 17215                 17220             


Ile Ala   Lys Asn Ala Ala Gly   Ala Ile Ser Lys Pro   Ser Asp Ser 
    17225                 17230                 17235             


Thr Gly   Pro Ile Thr Ala Lys   Asp Glu Val Glu Leu   Pro Arg Ile 
    17240                 17245                 17250             


Ser Met   Asp Pro Lys Phe Arg   Asp Thr Ile Val Val   Asn Ala Gly 
    17255                 17260                 17265             


Glu Thr   Phe Arg Leu Glu Ala   Asp Val His Gly Lys   Pro Leu Pro 
    17270                 17275                 17280             


Thr Ile   Glu Trp Leu Arg Gly   Asp Lys Glu Ile Glu   Glu Ser Ala 
    17285                 17290                 17295             


Arg Cys   Glu Ile Lys Asn Thr   Asp Phe Lys Ala Leu   Leu Ile Val 
    17300                 17305                 17310             


Lys Asp   Ala Ile Arg Ile Asp   Gly Gly Gln Tyr Ile   Leu Arg Ala 
    17315                 17320                 17325             


Ser Asn   Val Ala Gly Ser Lys   Ser Phe Pro Val Asn   Val Lys Val 
    17330                 17335                 17340             


Leu Asp   Arg Pro Gly Pro Pro   Glu Gly Pro Val Gln   Val Thr Gly 
    17345                 17350                 17355             


Val Thr   Ser Glu Lys Cys Ser   Leu Thr Trp Ser Pro   Pro Leu Gln 
    17360                 17365                 17370             


Asp Gly   Gly Ser Asp Ile Ser   His Tyr Val Val Glu   Lys Arg Glu 
    17375                 17380                 17385             


Thr Ser   Arg Leu Ala Trp Thr   Val Val Ala Ser Glu   Val Val Thr 
    17390                 17395                 17400             


Asn Ser   Leu Lys Val Thr Lys   Leu Leu Glu Gly Asn   Glu Tyr Val 
    17405                 17410                 17415             


Phe Arg   Ile Met Ala Val Asn   Lys Tyr Gly Val Gly   Glu Pro Leu 
    17420                 17425                 17430             


Glu Ser   Ala Pro Val Leu Met   Lys Asn Pro Phe Val   Leu Pro Gly 
    17435                 17440                 17445             


Pro Pro   Lys Ser Leu Glu Val   Thr Asn Ile Ala Lys   Asp Ser Met 
    17450                 17455                 17460             


Thr Val   Cys Trp Asn Arg Pro   Asp Ser Asp Gly Gly   Ser Glu Ile 
    17465                 17470                 17475             


Ile Gly   Tyr Ile Val Glu Lys   Arg Asp Arg Ser Gly   Ile Arg Trp 
    17480                 17485                 17490             


Ile Lys   Cys Asn Lys Arg Arg   Ile Thr Asp Leu Arg   Leu Arg Val 
    17495                 17500                 17505             


Thr Gly   Leu Thr Glu Asp His   Glu Tyr Glu Phe Arg   Val Ser Ala 
    17510                 17515                 17520             


Glu Asn   Ala Ala Gly Val Gly   Glu Pro Ser Pro Ala   Thr Val Tyr 
    17525                 17530                 17535             


Tyr Lys   Ala Cys Asp Pro Val   Phe Lys Pro Gly Pro   Pro Thr Asn 
    17540                 17545                 17550             


Ala His   Ile Val Asp Thr Thr   Lys Asn Ser Ile Thr   Leu Ala Trp 
    17555                 17560                 17565             


Gly Lys   Pro Ile Tyr Asp Gly   Gly Ser Glu Ile Leu   Gly Tyr Val 
    17570                 17575                 17580             


Val Glu   Ile Cys Lys Ala Asp   Glu Glu Glu Trp Gln   Ile Val Thr 
    17585                 17590                 17595             


Pro Gln   Thr Gly Leu Arg Val   Thr Arg Phe Glu Ile   Ser Lys Leu 
    17600                 17605                 17610             


Thr Glu   His Gln Glu Tyr Lys   Ile Arg Val Cys Ala   Leu Asn Lys 
    17615                 17620                 17625             


Val Gly   Leu Gly Glu Ala Thr   Ser Val Pro Gly Thr   Val Lys Pro 
    17630                 17635                 17640             


Glu Asp   Lys Leu Glu Ala Pro   Glu Leu Asp Leu Asp   Ser Glu Leu 
    17645                 17650                 17655             


Arg Lys   Gly Ile Val Val Arg   Ala Gly Gly Ser Ala   Arg Ile His 
    17660                 17665                 17670             


Ile Pro   Phe Lys Gly Arg Pro   Thr Pro Glu Ile Thr   Trp Ser Arg 
    17675                 17680                 17685             


Glu Glu   Gly Glu Phe Thr Asp   Lys Val Gln Ile Glu   Lys Gly Val 
    17690                 17695                 17700             


Asn Tyr   Thr Gln Leu Ser Ile   Asp Asn Cys Asp Arg   Asn Asp Ala 
    17705                 17710                 17715             


Gly Lys   Tyr Ile Leu Lys Leu   Glu Asn Ser Ser Gly   Ser Lys Ser 
    17720                 17725                 17730             


Ala Phe   Val Thr Val Lys Val   Leu Asp Thr Pro Gly   Pro Pro Gln 
    17735                 17740                 17745             


Asn Leu   Ala Val Lys Glu Val   Arg Lys Asp Ser Ala   Phe Leu Val 
    17750                 17755                 17760             


Trp Glu   Pro Pro Ile Ile Asp   Gly Gly Ala Lys Val   Lys Asn Tyr 
    17765                 17770                 17775             


Val Ile   Asp Lys Arg Glu Ser   Thr Arg Lys Ala Tyr   Ala Asn Val 
    17780                 17785                 17790             


Ser Ser   Lys Cys Ser Lys Thr   Ser Phe Lys Val Glu   Asn Leu Thr 
    17795                 17800                 17805             


Glu Gly   Ala Ile Tyr Tyr Phe   Arg Val Met Ala Glu   Asn Glu Phe 
    17810                 17815                 17820             


Gly Val   Gly Val Pro Val Glu   Thr Val Asp Ala Val   Lys Ala Ala 
    17825                 17830                 17835             


Glu Pro   Pro Ser Pro Pro Gly   Lys Val Thr Leu Thr   Asp Val Ser 
    17840                 17845                 17850             


Gln Thr   Ser Ala Ser Leu Met   Trp Glu Lys Pro Glu   His Asp Gly 
    17855                 17860                 17865             


Gly Ser   Arg Val Leu Gly Tyr   Val Val Glu Met Gln   Pro Lys Gly 
    17870                 17875                 17880             


Thr Glu   Lys Trp Ser Ile Val   Ala Glu Ser Lys Val   Cys Asn Ala 
    17885                 17890                 17895             


Val Val   Thr Gly Leu Ser Ser   Gly Gln Glu Tyr Gln   Phe Arg Val 
    17900                 17905                 17910             


Lys Ala   Tyr Asn Glu Lys Gly   Lys Ser Asp Pro Arg   Val Leu Gly 
    17915                 17920                 17925             


Val Pro   Val Ile Ala Lys Asp   Leu Thr Ile Gln Pro   Ser Leu Lys 
    17930                 17935                 17940             


Leu Pro   Phe Asn Thr Tyr Ser   Ile Gln Ala Gly Glu   Asp Leu Lys 
    17945                 17950                 17955             


Ile Glu   Ile Pro Val Ile Gly   Arg Pro Arg Pro Asn   Ile Ser Trp 
    17960                 17965                 17970             


Val Lys   Asp Gly Glu Pro Leu   Lys Gln Thr Thr Arg   Val Asn Val 
    17975                 17980                 17985             


Glu Glu   Thr Ala Thr Ser Thr   Val Leu His Ile Lys   Glu Gly Asn 
    17990                 17995                 18000             


Lys Asp   Asp Phe Gly Lys Tyr   Thr Val Thr Ala Thr   Asn Ser Ala 
    18005                 18010                 18015             


Gly Thr   Ala Thr Glu Asn Leu   Ser Val Ile Val Leu   Glu Lys Pro 
    18020                 18025                 18030             


Gly Pro   Pro Val Gly Pro Val   Arg Phe Asp Glu Val   Ser Ala Asp 
    18035                 18040                 18045             


Phe Val   Val Ile Ser Trp Glu   Pro Pro Ala Tyr Thr   Gly Gly Cys 
    18050                 18055                 18060             


Gln Ile   Ser Asn Tyr Ile Val   Glu Lys Arg Asp Thr   Thr Thr Thr 
    18065                 18070                 18075             


Thr Trp   His Met Val Ser Ala   Thr Val Ala Arg Thr   Thr Ile Lys 
    18080                 18085                 18090             


Ile Thr   Lys Leu Lys Thr Gly   Thr Glu Tyr Gln Phe   Arg Ile Phe 
    18095                 18100                 18105             


Ala Glu   Asn Arg Tyr Gly Lys   Ser Ala Pro Leu Asp   Ser Lys Ala 
    18110                 18115                 18120             


Val Ile   Val Gln Tyr Pro Phe   Lys Glu Pro Gly Pro   Pro Gly Thr 
    18125                 18130                 18135             


Pro Phe   Val Thr Ser Ile Ser   Lys Asp Gln Met Leu   Val Gln Trp 
    18140                 18145                 18150             


His Glu   Pro Val Asn Asp Gly   Gly Thr Lys Ile Ile   Gly Tyr His 
    18155                 18160                 18165             


Leu Glu   Gln Lys Glu Lys Asn   Ser Ile Leu Trp Val   Lys Leu Asn 
    18170                 18175                 18180             


Lys Thr   Pro Ile Gln Asp Thr   Lys Phe Lys Thr Thr   Gly Leu Asp 
    18185                 18190                 18195             


Glu Gly   Leu Glu Tyr Glu Phe   Lys Val Ser Ala Glu   Asn Ile Val 
    18200                 18205                 18210             


Gly Ile   Gly Lys Pro Ser Lys   Val Ser Glu Cys Phe   Val Ala Arg 
    18215                 18220                 18225             


Asp Pro   Cys Asp Pro Pro Gly   Arg Pro Glu Ala Ile   Val Ile Thr 
    18230                 18235                 18240             


Arg Asn   Asn Val Thr Leu Lys   Trp Lys Lys Pro Ala   Tyr Asp Gly 
    18245                 18250                 18255             


Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu Lys Lys   Asp Leu Pro 
    18260                 18265                 18270             


Asp Gly   Arg Trp Met Lys Ala   Ser Phe Thr Asn Val   Leu Glu Thr 
    18275                 18280                 18285             


Glu Phe   Thr Val Ser Gly Leu   Val Glu Asp Gln Arg   Tyr Glu Phe 
    18290                 18295                 18300             


Arg Val   Ile Ala Arg Asn Ala   Ala Gly Asn Phe Ser   Glu Pro Ser 
    18305                 18310                 18315             


Asp Ser   Ser Gly Ala Ile Thr   Ala Arg Asp Glu Ile   Asp Ala Pro 
    18320                 18325                 18330             


Asn Ala   Ser Leu Asp Pro Lys   Tyr Lys Asp Val Ile   Val Val His 
    18335                 18340                 18345             


Ala Gly   Glu Thr Phe Val Leu   Glu Ala Asp Ile Arg   Gly Lys Pro 
    18350                 18355                 18360             


Ile Pro   Asp Val Val Trp Ser   Lys Asp Gly Lys Glu   Leu Glu Glu 
    18365                 18370                 18375             


Thr Ala   Ala Arg Met Glu Ile   Lys Ser Thr Ile Gln   Lys Thr Thr 
    18380                 18385                 18390             


Leu Val   Val Lys Asp Cys Ile   Arg Thr Asp Gly Gly   Gln Tyr Ile 
    18395                 18400                 18405             


Leu Lys   Leu Ser Asn Val Gly   Gly Thr Lys Ser Ile   Pro Ile Thr 
    18410                 18415                 18420             


Val Lys   Val Leu Asp Arg Pro   Gly Pro Pro Glu Gly   Pro Leu Lys 
    18425                 18430                 18435             


Val Thr   Gly Val Thr Ala Glu   Lys Cys Tyr Leu Ala   Trp Asn Pro 
    18440                 18445                 18450             


Pro Leu   Gln Asp Gly Gly Ala   Asn Ile Ser His Tyr   Ile Ile Glu 
    18455                 18460                 18465             


Lys Arg   Glu Thr Ser Arg Leu   Ser Trp Thr Gln Val   Ser Thr Glu 
    18470                 18475                 18480             


Val Gln   Ala Leu Asn Tyr Lys   Val Thr Lys Leu Leu   Pro Gly Asn 
    18485                 18490                 18495             


Glu Tyr   Ile Phe Arg Val Met   Ala Val Asn Lys Tyr   Gly Ile Gly 
    18500                 18505                 18510             


Glu Pro   Leu Glu Ser Gly Pro   Val Thr Ala Cys Asn   Pro Tyr Lys 
    18515                 18520                 18525             


Pro Pro   Gly Pro Pro Ser Thr   Pro Glu Val Ser Ala   Ile Thr Lys 
    18530                 18535                 18540             


Asp Ser   Met Val Val Thr Trp   Ala Arg Pro Val Asp   Asp Gly Gly 
    18545                 18550                 18555             


Thr Glu   Ile Glu Gly Tyr Ile   Leu Glu Lys Arg Asp   Lys Glu Gly 
    18560                 18565                 18570             


Val Arg   Trp Thr Lys Cys Asn   Lys Lys Thr Leu Thr   Asp Leu Arg 
    18575                 18580                 18585             


Leu Arg   Val Thr Gly Leu Thr   Glu Gly His Ser Tyr   Glu Phe Arg 
    18590                 18595                 18600             


Val Ala   Ala Glu Asn Ala Ala   Gly Val Gly Glu Pro   Ser Glu Pro 
    18605                 18610                 18615             


Ser Val   Phe Tyr Arg Ala Cys   Asp Ala Leu Tyr Pro   Pro Gly Pro 
    18620                 18625                 18630             


Pro Ser   Asn Pro Lys Val Thr   Asp Thr Ser Arg Ser   Ser Val Ser 
    18635                 18640                 18645             


Leu Ala   Trp Ser Lys Pro Ile   Tyr Asp Gly Gly Ala   Pro Val Lys 
    18650                 18655                 18660             


Gly Tyr   Val Val Glu Val Lys   Glu Ala Ala Ala Asp   Glu Trp Thr 
    18665                 18670                 18675             


Thr Cys   Thr Pro Pro Thr Gly   Leu Gln Gly Lys Gln   Phe Thr Val 
    18680                 18685                 18690             


Thr Lys   Leu Lys Glu Asn Thr   Glu Tyr Asn Phe Arg   Ile Cys Ala 
    18695                 18700                 18705             


Ile Asn   Ser Glu Gly Val Gly   Glu Pro Ala Thr Leu   Pro Gly Ser 
    18710                 18715                 18720             


Val Val   Ala Gln Glu Arg Ile   Glu Pro Pro Glu Ile   Glu Leu Asp 
    18725                 18730                 18735             


Ala Asp   Leu Arg Lys Val Val   Val Leu Arg Ala Ser   Ala Thr Leu 
    18740                 18745                 18750             


Arg Leu   Phe Val Thr Ile Lys   Gly Arg Pro Glu Pro   Glu Val Lys 
    18755                 18760                 18765             


Trp Glu   Lys Ala Glu Gly Ile   Leu Thr Asp Arg Ala   Gln Ile Glu 
    18770                 18775                 18780             


Val Thr   Ser Ser Phe Thr Met   Leu Val Ile Asp Asn   Val Thr Arg 
    18785                 18790                 18795             


Phe Asp   Ser Gly Arg Tyr Asn   Leu Thr Leu Glu Asn   Asn Ser Gly 
    18800                 18805                 18810             


Ser Lys   Thr Ala Phe Val Asn   Val Arg Val Leu Asp   Ser Pro Ser 
    18815                 18820                 18825             


Ala Pro   Val Asn Leu Thr Ile   Arg Glu Val Lys Lys   Asp Ser Val 
    18830                 18835                 18840             


Thr Leu   Ser Trp Glu Pro Pro   Leu Ile Asp Gly Gly   Ala Lys Ile 
    18845                 18850                 18855             


Thr Asn   Tyr Ile Val Glu Lys   Arg Glu Thr Thr Arg   Lys Ala Tyr 
    18860                 18865                 18870             


Ala Thr   Ile Thr Asn Asn Cys   Thr Lys Thr Thr Phe   Arg Ile Glu 
    18875                 18880                 18885             


Asn Leu   Gln Glu Gly Cys Ser   Tyr Tyr Phe Arg Val   Leu Ala Ser 
    18890                 18895                 18900             


Asn Glu   Tyr Gly Ile Gly Leu   Pro Ala Glu Thr Thr   Glu Pro Val 
    18905                 18910                 18915             


Lys Val   Ser Glu Pro Pro Leu   Pro Pro Gly Arg Val   Thr Leu Val 
    18920                 18925                 18930             


Asp Val   Thr Arg Asn Thr Ala   Thr Ile Lys Trp Glu   Lys Pro Glu 
    18935                 18940                 18945             


Ser Asp   Gly Gly Ser Lys Ile   Thr Gly Tyr Val Val   Glu Met Gln 
    18950                 18955                 18960             


Thr Lys   Gly Ser Glu Lys Trp   Ser Thr Cys Thr Gln   Val Lys Thr 
    18965                 18970                 18975             


Leu Glu   Ala Thr Ile Ser Gly   Leu Thr Ala Gly Glu   Glu Tyr Val 
    18980                 18985                 18990             


Phe Arg   Val Ala Ala Val Asn   Glu Lys Gly Arg Ser   Asp Pro Arg 
    18995                 19000                 19005             


Gln Leu   Gly Val Pro Val Ile   Ala Arg Asp Ile Glu   Ile Lys Pro 
    19010                 19015                 19020             


Ser Val   Glu Leu Pro Phe His   Thr Phe Asn Val Lys   Ala Arg Glu 
    19025                 19030                 19035             


Gln Leu   Lys Ile Asp Val Pro   Phe Lys Gly Arg Pro   Gln Ala Thr 
    19040                 19045                 19050             


Val Asn   Trp Arg Lys Asp Gly   Gln Thr Leu Lys Glu   Thr Thr Arg 
    19055                 19060                 19065             


Val Asn   Val Ser Ser Ser Lys   Thr Val Thr Ser Leu   Ser Ile Lys 
    19070                 19075                 19080             


Glu Ala   Ser Lys Glu Asp Val   Gly Thr Tyr Glu Leu   Cys Val Ser 
    19085                 19090                 19095             


Asn Ser   Ala Gly Ser Ile Thr   Val Pro Ile Thr Ile   Ile Val Leu 
    19100                 19105                 19110             


Asp Arg   Pro Gly Pro Pro Gly   Pro Ile Arg Ile Asp   Glu Val Ser 
    19115                 19120                 19125             


Cys Asp   Ser Ile Thr Ile Ser   Trp Asn Pro Pro Glu   Tyr Asp Gly 
    19130                 19135                 19140             


Gly Cys   Gln Ile Ser Asn Tyr   Ile Val Glu Lys Lys   Glu Thr Thr 
    19145                 19150                 19155             


Ser Thr   Thr Trp His Ile Val   Ser Gln Ala Val Ala   Arg Thr Ser 
    19160                 19165                 19170             


Ile Lys   Ile Val Arg Leu Thr   Thr Gly Ser Glu Tyr   Gln Phe Arg 
    19175                 19180                 19185             


Val Cys   Ala Glu Asn Arg Tyr   Gly Lys Ser Ser Tyr   Ser Glu Ser 
    19190                 19195                 19200             


Ser Ala   Val Val Ala Glu Tyr   Pro Phe Ser Pro Pro   Gly Pro Pro 
    19205                 19210                 19215             


Gly Thr   Pro Lys Val Val His   Ala Thr Lys Ser Thr   Met Leu Val 
    19220                 19225                 19230             


Thr Trp   Gln Val Pro Val Asn   Asp Gly Gly Ser Arg   Val Ile Gly 
    19235                 19240                 19245             


Tyr His   Leu Glu Tyr Lys Glu   Arg Ser Ser Ile Leu   Trp Ser Lys 
    19250                 19255                 19260             


Ala Asn   Lys Ile Leu Ile Ala   Asp Thr Gln Met Lys   Val Ser Gly 
    19265                 19270                 19275             


Leu Asp   Glu Gly Leu Met Tyr   Glu Tyr Arg Val Tyr   Ala Glu Asn 
    19280                 19285                 19290             


Ile Ala   Gly Ile Gly Lys Cys   Ser Lys Ser Cys Glu   Pro Val Pro 
    19295                 19300                 19305             


Ala Arg   Asp Pro Cys Asp Pro   Pro Gly Gln Pro Glu   Val Thr Asn 
    19310                 19315                 19320             


Ile Thr   Arg Lys Ser Val Ser   Leu Lys Trp Ser Lys   Pro His Tyr 
    19325                 19330                 19335             


Asp Gly   Gly Ala Lys Ile Thr   Gly Tyr Ile Val Glu   Arg Arg Glu 
    19340                 19345                 19350             


Leu Pro   Asp Gly Arg Trp Leu   Lys Cys Asn Tyr Thr   Asn Ile Gln 
    19355                 19360                 19365             


Glu Thr   Tyr Phe Glu Val Thr   Glu Leu Thr Glu Asp   Gln Arg Tyr 
    19370                 19375                 19380             


Glu Phe   Arg Val Phe Ala Arg   Asn Ala Ala Asp Ser   Val Ser Glu 
    19385                 19390                 19395             


Pro Ser   Glu Ser Thr Gly Pro   Ile Ile Val Lys Asp   Asp Val Glu 
    19400                 19405                 19410             


Pro Pro   Arg Val Met Met Asp   Val Lys Phe Arg Asp   Val Ile Val 
    19415                 19420                 19425             


Val Lys   Ala Gly Glu Val Leu   Lys Ile Asn Ala Asp   Ile Ala Gly 
    19430                 19435                 19440             


Arg Pro   Leu Pro Val Ile Ser   Trp Ala Lys Asp Gly   Ile Glu Ile 
    19445                 19450                 19455             


Glu Glu   Arg Ala Arg Thr Glu   Ile Ile Ser Thr Asp   Asn His Thr 
    19460                 19465                 19470             


Leu Leu   Thr Val Lys Asp Cys   Ile Arg Arg Asp Thr   Gly Gln Tyr 
    19475                 19480                 19485             


Val Leu   Thr Leu Lys Asn Val   Ala Gly Thr Arg Ser   Val Ala Val 
    19490                 19495                 19500             


Asn Cys   Lys Val Leu Asp Lys   Pro Gly Pro Pro Ala   Gly Pro Leu 
    19505                 19510                 19515             


Glu Ile   Asn Gly Leu Thr Ala   Glu Lys Cys Ser Leu   Ser Trp Gly 
    19520                 19525                 19530             


Arg Pro   Gln Glu Asp Gly Gly   Ala Asp Ile Asp Tyr   Tyr Ile Val 
    19535                 19540                 19545             


Glu Lys   Arg Glu Thr Ser His   Leu Ala Trp Thr Ile   Cys Glu Gly 
    19550                 19555                 19560             


Glu Leu   Gln Met Thr Ser Cys   Lys Val Thr Lys Leu   Leu Lys Gly 
    19565                 19570                 19575             


Asn Glu   Tyr Ile Phe Arg Val   Thr Gly Val Asn Lys   Tyr Gly Val 
    19580                 19585                 19590             


Gly Glu   Pro Leu Glu Ser Val   Ala Ile Lys Ala Leu   Asp Pro Phe 
    19595                 19600                 19605             


Thr Val   Pro Ser Pro Pro Thr   Ser Leu Glu Ile Thr   Ser Val Thr 
    19610                 19615                 19620             


Lys Glu   Ser Met Thr Leu Cys   Trp Ser Arg Pro Glu   Ser Asp Gly 
    19625                 19630                 19635             


Gly Ser   Glu Ile Ser Gly Tyr   Ile Ile Glu Arg Arg   Glu Lys Asn 
    19640                 19645                 19650             


Ser Leu   Arg Trp Val Arg Val   Asn Lys Lys Pro Val   Tyr Asp Leu 
    19655                 19660                 19665             


Arg Val   Lys Ser Thr Gly Leu   Arg Glu Gly Cys Glu   Tyr Glu Tyr 
    19670                 19675                 19680             


Arg Val   Tyr Ala Glu Asn Ala   Ala Gly Leu Ser Leu   Pro Ser Glu 
    19685                 19690                 19695             


Thr Ser   Pro Leu Ile Arg Ala   Glu Asp Pro Val Phe   Leu Pro Ser 
    19700                 19705                 19710             


Pro Pro   Ser Lys Pro Lys Ile   Val Asp Ser Gly Lys   Thr Thr Ile 
    19715                 19720                 19725             


Thr Ile   Ala Trp Val Lys Pro   Leu Phe Asp Gly Gly   Ala Pro Ile 
    19730                 19735                 19740             


Thr Gly   Tyr Thr Val Glu Tyr   Lys Lys Ser Asp Asp   Thr Asp Trp 
    19745                 19750                 19755             


Lys Thr   Ser Ile Gln Ser Leu   Arg Gly Thr Glu Tyr   Thr Ile Ser 
    19760                 19765                 19770             


Gly Leu   Thr Thr Gly Ala Glu   Tyr Val Phe Arg Val   Lys Ser Val 
    19775                 19780                 19785             


Asn Lys   Val Gly Ala Ser Asp   Pro Ser Asp Ser Ser   Asp Pro Gln 
    19790                 19795                 19800             


Ile Ala   Lys Glu Arg Glu Glu   Glu Pro Leu Phe Asp   Ile Asp Ser 
    19805                 19810                 19815             


Glu Met   Arg Lys Thr Leu Ile   Val Lys Ala Gly Ala   Ser Phe Thr 
    19820                 19825                 19830             


Met Thr   Val Pro Phe Arg Gly   Arg Pro Val Pro Asn   Val Leu Trp 
    19835                 19840                 19845             


Ser Lys   Pro Asp Thr Asp Leu   Arg Thr Arg Ala Tyr   Val Asp Thr 
    19850                 19855                 19860             


Thr Asp   Ser Arg Thr Ser Leu   Thr Ile Glu Asn Ala   Asn Arg Asn 
    19865                 19870                 19875             


Asp Ser   Gly Lys Tyr Thr Leu   Thr Ile Gln Asn Val   Leu Ser Ala 
    19880                 19885                 19890             


Ala Ser   Leu Thr Leu Val Val   Lys Val Leu Asp Thr   Pro Gly Pro 
    19895                 19900                 19905             


Pro Thr   Asn Ile Thr Val Gln   Asp Val Thr Lys Glu   Ser Ala Val 
    19910                 19915                 19920             


Leu Ser   Trp Asp Val Pro Glu   Asn Asp Gly Gly Ala   Pro Val Lys 
    19925                 19930                 19935             


Asn Tyr   His Ile Glu Lys Arg   Glu Ala Ser Lys Lys   Ala Trp Val 
    19940                 19945                 19950             


Ser Val   Thr Asn Asn Cys Asn   Arg Leu Ser Tyr Lys   Val Thr Asn 
    19955                 19960                 19965             


Leu Gln   Glu Gly Ala Ile Tyr   Tyr Phe Arg Val Ser   Gly Glu Asn 
    19970                 19975                 19980             


Glu Phe   Gly Val Gly Ile Pro   Ala Glu Thr Lys Glu   Gly Val Lys 
    19985                 19990                 19995             


Ile Thr   Glu Lys Pro Ser Pro   Pro Glu Lys Leu Gly   Val Thr Ser 
    20000                 20005                 20010             


Ile Ser   Lys Asp Ser Val Ser   Leu Thr Trp Leu Lys   Pro Glu His 
    20015                 20020                 20025             


Asp Gly   Gly Ser Arg Ile Val   His Tyr Val Val Glu   Ala Leu Glu 
    20030                 20035                 20040             


Lys Gly   Gln Lys Asn Trp Val   Lys Cys Ala Val Ala   Lys Ser Thr 
    20045                 20050                 20055             


His His   Val Val Ser Gly Leu   Arg Glu Asn Ser Glu   Tyr Phe Phe 
    20060                 20065                 20070             


Arg Val   Phe Ala Glu Asn Gln   Ala Gly Leu Ser Asp   Pro Arg Glu 
    20075                 20080                 20085             


Leu Leu   Leu Pro Val Leu Ile   Lys Glu Gln Leu Glu   Pro Pro Glu 
    20090                 20095                 20100             


Ile Asp   Met Lys Asn Phe Pro   Ser His Thr Val Tyr   Val Arg Ala 
    20105                 20110                 20115             


Gly Ser   Asn Leu Lys Val Asp   Ile Pro Ile Ser Gly   Lys Pro Leu 
    20120                 20125                 20130             


Pro Lys   Val Thr Leu Ser Arg   Asp Gly Val Pro Leu   Lys Ala Thr 
    20135                 20140                 20145             


Met Arg   Phe Asn Thr Glu Ile   Thr Ala Glu Asn Leu   Thr Ile Asn 
    20150                 20155                 20160             


Leu Lys   Glu Ser Val Thr Ala   Asp Ala Gly Arg Tyr   Glu Ile Thr 
    20165                 20170                 20175             


Ala Ala   Asn Ser Ser Gly Thr   Thr Lys Ala Phe Ile   Asn Ile Val 
    20180                 20185                 20190             


Val Leu   Asp Arg Pro Gly Pro   Pro Thr Gly Pro Val   Val Ile Ser 
    20195                 20200                 20205             


Asp Ile   Thr Glu Glu Ser Val   Thr Leu Lys Trp Glu   Pro Pro Lys 
    20210                 20215                 20220             


Tyr Asp   Gly Gly Ser Gln Val   Thr Asn Tyr Ile Leu   Leu Lys Arg 
    20225                 20230                 20235             


Glu Thr   Ser Thr Ala Val Trp   Thr Glu Val Ser Ala   Thr Val Ala 
    20240                 20245                 20250             


Arg Thr   Met Met Lys Val Met   Lys Leu Thr Thr Gly   Glu Glu Tyr 
    20255                 20260                 20265             


Gln Phe   Arg Ile Lys Ala Glu   Asn Arg Phe Gly Ile   Ser Asp His 
    20270                 20275                 20280             


Ile Asp   Ser Ala Cys Val Thr   Val Lys Leu Pro Tyr   Thr Thr Pro 
    20285                 20290                 20295             


Gly Pro   Pro Ser Thr Pro Trp   Val Thr Asn Val Thr   Arg Glu Ser 
    20300                 20305                 20310             


Ile Thr   Val Gly Trp His Glu   Pro Val Ser Asn Gly   Gly Ser Ala 
    20315                 20320                 20325             


Val Val   Gly Tyr His Leu Glu   Met Lys Asp Arg Asn   Ser Ile Leu 
    20330                 20335                 20340             


Trp Gln   Lys Ala Asn Lys Leu   Val Ile Arg Thr Thr   His Phe Lys 
    20345                 20350                 20355             


Val Thr   Thr Ile Ser Ala Gly   Leu Ile Tyr Glu Phe   Arg Val Tyr 
    20360                 20365                 20370             


Ala Glu   Asn Ala Ala Gly Val   Gly Lys Pro Ser His   Pro Ser Glu 
    20375                 20380                 20385             


Pro Val   Leu Ala Ile Asp Ala   Cys Glu Pro Pro Arg   Asn Val Arg 
    20390                 20395                 20400             


Ile Thr   Asp Ile Ser Lys Asn   Ser Val Ser Leu Ser   Trp Gln Gln 
    20405                 20410                 20415             


Pro Ala   Phe Asp Gly Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu 
    20420                 20425                 20430             


Arg Arg   Asp Leu Pro Asp Gly   Arg Trp Thr Lys Ala   Ser Phe Thr 
    20435                 20440                 20445             


Asn Val   Thr Glu Thr Gln Phe   Ile Ile Ser Gly Leu   Thr Gln Asn 
    20450                 20455                 20460             


Ser Gln   Tyr Glu Phe Arg Val   Phe Ala Arg Asn Ala   Val Gly Ser 
    20465                 20470                 20475             


Ile Ser   Asn Pro Ser Glu Val   Val Gly Pro Ile Thr   Cys Ile Asp 
    20480                 20485                 20490             


Ser Tyr   Gly Gly Pro Val Ile   Asp Leu Pro Leu Glu   Tyr Thr Glu 
    20495                 20500                 20505             


Val Val   Lys Tyr Arg Ala Gly   Thr Ser Val Lys Leu   Arg Ala Gly 
    20510                 20515                 20520             


Ile Ser   Gly Lys Pro Ala Pro   Thr Ile Glu Trp Tyr   Lys Asp Asp 
    20525                 20530                 20535             


Lys Glu   Leu Gln Thr Asn Ala   Leu Val Cys Val Glu   Asn Thr Thr 
    20540                 20545                 20550             


Asp Leu   Ala Ser Ile Leu Ile   Lys Asp Ala Asp Arg   Leu Asn Ser 
    20555                 20560                 20565             


Gly Cys   Tyr Glu Leu Lys Leu   Arg Asn Ala Met Gly   Ser Ala Ser 
    20570                 20575                 20580             


Ala Thr   Ile Arg Val Gln Ile   Leu Asp Lys Pro Gly   Pro Pro Gly 
    20585                 20590                 20595             


Gly Pro   Ile Glu Phe Lys Thr   Val Thr Ala Glu Lys   Ile Thr Leu 
    20600                 20605                 20610             


Leu Trp   Arg Pro Pro Ala Asp   Asp Gly Gly Ala Lys   Ile Thr His 
    20615                 20620                 20625             


Tyr Ile   Val Glu Lys Arg Glu   Thr Ser Arg Val Val   Trp Ser Met 
    20630                 20635                 20640             


Val Ser   Glu His Leu Glu Glu   Cys Ile Ile Thr Thr   Thr Lys Ile 
    20645                 20650                 20655             


Ile Lys   Gly Asn Glu Tyr Ile   Phe Arg Val Arg Ala   Val Asn Lys 
    20660                 20665                 20670             


Tyr Gly   Ile Gly Glu Pro Leu   Glu Ser Asp Ser Val   Val Ala Lys 
    20675                 20680                 20685             


Asn Ala   Phe Val Thr Pro Gly   Pro Pro Gly Ile Pro   Glu Val Thr 
    20690                 20695                 20700             


Lys Ile   Thr Lys Asn Ser Met   Thr Val Val Trp Ser   Arg Pro Ile 
    20705                 20710                 20715             


Ala Asp   Gly Gly Ser Asp Ile   Ser Gly Tyr Phe Leu   Glu Lys Arg 
    20720                 20725                 20730             


Asp Lys   Lys Ser Leu Gly Trp   Phe Lys Val Leu Lys   Glu Thr Ile 
    20735                 20740                 20745             


Arg Asp   Thr Arg Gln Lys Val   Thr Gly Leu Thr Glu   Asn Ser Asp 
    20750                 20755                 20760             


Tyr Gln   Tyr Arg Val Cys Ala   Val Asn Ala Ala Gly   Gln Gly Pro 
    20765                 20770                 20775             


Phe Ser   Glu Pro Ser Glu Phe   Tyr Lys Ala Ala Asp   Pro Ile Asp 
    20780                 20785                 20790             


Pro Pro   Gly Pro Pro Ala Lys   Ile Arg Ile Ala Asp   Ser Thr Lys 
    20795                 20800                 20805             


Ser Ser   Ile Thr Leu Gly Trp   Ser Lys Pro Val Tyr   Asp Gly Gly 
    20810                 20815                 20820             


Ser Ala   Val Thr Gly Tyr Val   Val Glu Ile Arg Gln   Gly Glu Glu 
    20825                 20830                 20835             


Glu Glu   Trp Thr Thr Val Ser   Thr Lys Gly Glu Val   Arg Thr Thr 
    20840                 20845                 20850             


Glu Tyr   Val Val Ser Asn Leu   Lys Pro Gly Val Asn   Tyr Tyr Phe 
    20855                 20860                 20865             


Arg Val   Ser Ala Val Asn Cys   Ala Gly Gln Gly Glu   Pro Ile Glu 
    20870                 20875                 20880             


Met Asn   Glu Pro Val Gln Ala   Lys Asp Ile Leu Glu   Ala Pro Glu 
    20885                 20890                 20895             


Ile Asp   Leu Asp Val Ala Leu   Arg Thr Ser Val Ile   Ala Lys Ala 
    20900                 20905                 20910             


Gly Glu   Asp Val Gln Val Leu   Ile Pro Phe Lys Gly   Arg Pro Pro 
    20915                 20920                 20925             


Pro Thr   Val Thr Trp Arg Lys   Asp Glu Lys Asn Leu   Gly Ser Asp 
    20930                 20935                 20940             


Ala Arg   Tyr Ser Ile Glu Asn   Thr Asp Ser Ser Ser   Leu Leu Thr 
    20945                 20950                 20955             


Ile Pro   Gln Val Thr Arg Asn   Asp Thr Gly Lys Tyr   Ile Leu Thr 
    20960                 20965                 20970             


Ile Glu   Asn Gly Val Gly Glu   Pro Lys Ser Ser Thr   Val Ser Val 
    20975                 20980                 20985             


Lys Val   Leu Asp Thr Pro Ala   Ala Cys Gln Lys Leu   Gln Val Lys 
    20990                 20995                 21000             


His Val   Ser Arg Gly Thr Val   Thr Leu Leu Trp Asp   Pro Pro Leu 
    21005                 21010                 21015             


Ile Asp   Gly Gly Ser Pro Ile   Ile Asn Tyr Val Ile   Glu Lys Arg 
    21020                 21025                 21030             


Asp Ala   Thr Lys Arg Thr Trp   Ser Val Val Ser His   Lys Cys Ser 
    21035                 21040                 21045             


Ser Thr   Ser Phe Lys Leu Ile   Asp Leu Ser Glu Lys   Thr Pro Phe 
    21050                 21055                 21060             


Phe Phe   Arg Val Leu Ala Glu   Asn Glu Ile Gly Ile   Gly Glu Pro 
    21065                 21070                 21075             


Cys Glu   Thr Thr Glu Pro Val   Lys Ala Ala Glu Val   Pro Ala Pro 
    21080                 21085                 21090             


Ile Arg   Asp Leu Ser Met Lys   Asp Ser Thr Lys Thr   Ser Val Ile 
    21095                 21100                 21105             


Leu Ser   Trp Thr Lys Pro Asp   Phe Asp Gly Gly Ser   Val Ile Thr 
    21110                 21115                 21120             


Glu Tyr   Val Val Glu Arg Lys   Gly Lys Gly Glu Gln   Thr Trp Ser 
    21125                 21130                 21135             


His Ala   Gly Ile Ser Lys Thr   Cys Glu Ile Glu Val   Ser Gln Leu 
    21140                 21145                 21150             


Lys Glu   Gln Ser Val Leu Glu   Phe Arg Val Phe Ala   Lys Asn Glu 
    21155                 21160                 21165             


Lys Gly   Leu Ser Asp Pro Val   Thr Ile Gly Pro Ile   Thr Val Lys 
    21170                 21175                 21180             


Glu Leu   Ile Ile Thr Pro Glu   Val Asp Leu Ser Asp   Ile Pro Gly 
    21185                 21190                 21195             


Ala Gln   Val Thr Val Arg Ile   Gly His Asn Val His   Leu Glu Leu 
    21200                 21205                 21210             


Pro Tyr   Lys Gly Lys Pro Lys   Pro Ser Ile Ser Trp   Leu Lys Asp 
    21215                 21220                 21225             


Gly Leu   Pro Leu Lys Glu Ser   Glu Phe Val Arg Phe   Ser Lys Thr 
    21230                 21235                 21240             


Glu Asn   Lys Ile Thr Leu Ser   Ile Lys Asn Ala Lys   Lys Glu His 
    21245                 21250                 21255             


Gly Gly   Lys Tyr Thr Val Ile   Leu Asp Asn Ala Val   Cys Arg Ile 
    21260                 21265                 21270             


Ala Val   Pro Ile Thr Val Ile   Thr Leu Gly Pro Pro   Ser Lys Pro 
    21275                 21280                 21285             


Lys Gly   Pro Ile Arg Phe Asp   Glu Ile Lys Ala Asp   Ser Val Ile 
    21290                 21295                 21300             


Leu Ser   Trp Asp Val Pro Glu   Asp Asn Gly Gly Gly   Glu Ile Thr 
    21305                 21310                 21315             


Cys Tyr   Ser Ile Glu Lys Arg   Glu Thr Ser Gln Thr   Asn Trp Arg 
    21320                 21325                 21330             


Met Val   Cys Ser Ser Val Ala   Arg Thr Thr Phe Lys   Val Pro Asn 
    21335                 21340                 21345             


Leu Val   Lys Asp Ala Glu Tyr   Gln Phe Arg Val Arg   Ala Glu Asn 
    21350                 21355                 21360             


Arg Tyr   Gly Val Ser Gln Pro   Leu Val Ser Ser Ile   Ile Val Ala 
    21365                 21370                 21375             


Lys His   Gln Phe Arg Ile Pro   Gly Pro Pro Gly Lys   Pro Val Ile 
    21380                 21385                 21390             


Tyr Asn   Val Thr Ser Asp Gly   Met Ser Leu Thr Trp   Asp Ala Pro 
    21395                 21400                 21405             


Val Tyr   Asp Gly Gly Ser Glu   Val Thr Gly Phe His   Val Glu Lys 
    21410                 21415                 21420             


Lys Glu   Arg Asn Ser Ile Leu   Trp Gln Lys Val Asn   Thr Ser Pro 
    21425                 21430                 21435             


Ile Ser   Gly Arg Glu Tyr Arg   Ala Thr Gly Leu Val   Glu Gly Leu 
    21440                 21445                 21450             


Asp Tyr   Gln Phe Arg Val Tyr   Ala Glu Asn Ser Ala   Gly Leu Ser 
    21455                 21460                 21465             


Ser Pro   Ser Asp Pro Ser Lys   Phe Thr Leu Ala Val   Ser Pro Val 
    21470                 21475                 21480             


Asp Pro   Pro Gly Thr Pro Asp   Tyr Ile Asp Val Thr   Arg Glu Thr 
    21485                 21490                 21495             


Ile Thr   Leu Lys Trp Asn Pro   Pro Leu Arg Asp Gly   Gly Ser Lys 
    21500                 21505                 21510             


Ile Val   Gly Tyr Ser Ile Glu   Lys Arg Gln Gly Asn   Glu Arg Trp 
    21515                 21520                 21525             


Val Arg   Cys Asn Phe Thr Asp   Val Ser Glu Cys Gln   Tyr Thr Val 
    21530                 21535                 21540             


Thr Gly   Leu Ser Pro Gly Asp   Arg Tyr Glu Phe Arg   Ile Ile Ala 
    21545                 21550                 21555             


Arg Asn   Ala Val Gly Thr Ile   Ser Pro Pro Ser Gln   Ser Ser Gly 
    21560                 21565                 21570             


Ile Ile   Met Thr Arg Asp Glu   Asn Val Pro Pro Ile   Val Glu Phe 
    21575                 21580                 21585             


Gly Pro   Glu Tyr Phe Asp Gly   Leu Ile Ile Lys Ser   Gly Glu Ser 
    21590                 21595                 21600             


Leu Arg   Ile Lys Ala Leu Val   Gln Gly Arg Pro Val   Pro Arg Val 
    21605                 21610                 21615             


Thr Trp   Phe Lys Asp Gly Val   Glu Ile Glu Lys Arg   Met Asn Met 
    21620                 21625                 21630             


Glu Ile   Thr Asp Val Leu Gly   Ser Thr Ser Leu Phe   Val Arg Asp 
    21635                 21640                 21645             


Ala Thr   Arg Asp His Arg Gly   Val Tyr Thr Val Glu   Ala Lys Asn 
    21650                 21655                 21660             


Ala Ser   Gly Ser Ala Lys Ala   Glu Ile Lys Val Lys   Val Gln Asp 
    21665                 21670                 21675             


Thr Pro   Gly Lys Val Val Gly   Pro Ile Arg Phe Thr   Asn Ile Thr 
    21680                 21685                 21690             


Gly Glu   Lys Met Thr Leu Trp   Trp Asp Ala Pro Leu   Asn Asp Gly 
    21695                 21700                 21705             


Cys Ala   Pro Ile Thr His Tyr   Ile Ile Glu Lys Arg   Glu Thr Ser 
    21710                 21715                 21720             


Arg Leu   Ala Trp Ala Leu Ile   Glu Asp Lys Cys Glu   Ala Gln Ser 
    21725                 21730                 21735             


Tyr Thr   Ala Ile Lys Leu Ile   Asn Gly Asn Glu Tyr   Gln Phe Arg 
    21740                 21745                 21750             


Val Ser   Ala Val Asn Lys Phe   Gly Val Gly Arg Pro   Leu Asp Ser 
    21755                 21760                 21765             


Asp Pro   Val Val Ala Gln Ile   Gln Tyr Thr Val Pro   Asp Ala Pro 
    21770                 21775                 21780             


Gly Ile   Pro Glu Pro Ser Asn   Ile Thr Gly Asn Ser   Ile Thr Leu 
    21785                 21790                 21795             


Thr Trp   Ala Arg Pro Glu Ser   Asp Gly Gly Ser Glu   Ile Gln Gln 
    21800                 21805                 21810             


Tyr Ile   Leu Glu Arg Arg Glu   Lys Lys Ser Thr Arg   Trp Val Lys 
    21815                 21820                 21825             


Val Ile   Ser Lys Arg Pro Ile   Ser Glu Thr Arg Phe   Lys Val Thr 
    21830                 21835                 21840             


Gly Leu   Thr Glu Gly Asn Glu   Tyr Glu Phe His Val   Met Ala Glu 
    21845                 21850                 21855             


Asn Ala   Ala Gly Val Gly Pro   Ala Ser Gly Ile Ser   Arg Leu Ile 
    21860                 21865                 21870             


Lys Cys   Arg Glu Pro Val Asn   Pro Pro Gly Pro Pro   Thr Val Val 
    21875                 21880                 21885             


Lys Val   Thr Asp Thr Ser Lys   Thr Thr Val Ser Leu   Glu Trp Ser 
    21890                 21895                 21900             


Lys Pro   Val Phe Asp Gly Gly   Met Glu Ile Ile Gly   Tyr Ile Ile 
    21905                 21910                 21915             


Glu Met   Cys Lys Ala Asp Leu   Gly Asp Trp His Lys   Val Asn Ala 
    21920                 21925                 21930             


Glu Ala   Cys Val Lys Thr Arg   Tyr Thr Val Thr Asp   Leu Gln Ala 
    21935                 21940                 21945             


Gly Glu   Glu Tyr Lys Phe Arg   Val Ser Ala Ile Asn   Gly Ala Gly 
    21950                 21955                 21960             


Lys Gly   Asp Ser Cys Glu Val   Thr Gly Thr Ile Lys   Ala Val Asp 
    21965                 21970                 21975             


Arg Leu   Thr Ala Pro Glu Leu   Asp Ile Asp Ala Asn   Phe Lys Gln 
    21980                 21985                 21990             


Thr His   Val Val Arg Ala Gly   Ala Ser Ile Arg Leu   Phe Ile Ala 
    21995                 22000                 22005             


Tyr Gln   Gly Arg Pro Thr Pro   Thr Ala Val Trp Ser   Lys Pro Asp 
    22010                 22015                 22020             


Ser Asn   Leu Ser Leu Arg Ala   Asp Ile His Thr Thr   Asp Ser Phe 
    22025                 22030                 22035             


Ser Thr   Leu Thr Val Glu Asn   Cys Asn Arg Asn Asp   Ala Gly Lys 
    22040                 22045                 22050             


Tyr Thr   Leu Thr Val Glu Asn   Asn Ser Gly Ser Lys   Ser Ile Thr 
    22055                 22060                 22065             


Phe Thr   Val Lys Val Leu Asp   Thr Pro Gly Pro Pro   Gly Pro Ile 
    22070                 22075                 22080             


Thr Phe   Lys Asp Val Thr Arg   Gly Ser Ala Thr Leu   Met Trp Asp 
    22085                 22090                 22095             


Ala Pro   Leu Leu Asp Gly Gly   Ala Arg Ile His His   Tyr Val Val 
    22100                 22105                 22110             


Glu Lys   Arg Glu Ala Ser Arg   Arg Ser Trp Gln Val   Ile Ser Glu 
    22115                 22120                 22125             


Lys Cys   Thr Arg Gln Ile Phe   Lys Val Asn Asp Leu   Ala Glu Gly 
    22130                 22135                 22140             


Val Pro   Tyr Tyr Phe Arg Val   Ser Ala Val Asn Glu   Tyr Gly Val 
    22145                 22150                 22155             


Gly Glu   Pro Tyr Glu Met Pro   Glu Pro Ile Val Ala   Thr Glu Gln 
    22160                 22165                 22170             


Pro Ala   Pro Pro Arg Arg Leu   Asp Val Val Asp Thr   Ser Lys Ser 
    22175                 22180                 22185             


Ser Ala   Val Leu Ala Trp Leu   Lys Pro Asp His Asp   Gly Gly Ser 
    22190                 22195                 22200             


Arg Ile   Thr Gly Tyr Leu Leu   Glu Met Arg Gln Lys   Gly Ser Asp 
    22205                 22210                 22215             


Phe Trp   Val Glu Ala Gly His   Thr Lys Gln Leu Thr   Phe Thr Val 
    22220                 22225                 22230             


Glu Arg   Leu Val Glu Lys Thr   Glu Tyr Glu Phe Arg   Val Lys Ala 
    22235                 22240                 22245             


Lys Asn   Asp Ala Gly Tyr Ser   Glu Pro Arg Glu Ala   Phe Ser Ser 
    22250                 22255                 22260             


Val Ile   Ile Lys Glu Pro Gln   Ile Glu Pro Thr Ala   Asp Leu Thr 
    22265                 22270                 22275             


Gly Ile   Thr Asn Gln Leu Ile   Thr Cys Lys Ala Gly   Ser Pro Phe 
    22280                 22285                 22290             


Thr Ile   Asp Val Pro Ile Ser   Gly Arg Pro Ala Pro   Lys Val Thr 
    22295                 22300                 22305             


Trp Lys   Leu Glu Glu Met Arg   Leu Lys Glu Thr Asp   Arg Val Ser 
    22310                 22315                 22320             


Ile Thr   Thr Thr Lys Asp Arg   Thr Thr Leu Thr Val   Lys Asp Ser 
    22325                 22330                 22335             


Met Arg   Gly Asp Ser Gly Arg   Tyr Phe Leu Thr Leu   Glu Asn Thr 
    22340                 22345                 22350             


Ala Gly   Val Lys Thr Phe Ser   Val Thr Val Val Val   Ile Gly Arg 
    22355                 22360                 22365             


Pro Gly   Pro Val Thr Gly Pro   Ile Glu Val Ser Ser   Val Ser Ala 
    22370                 22375                 22380             


Glu Ser   Cys Val Leu Ser Trp   Gly Glu Pro Lys Asp   Gly Gly Gly 
    22385                 22390                 22395             


Thr Glu   Ile Thr Asn Tyr Ile   Val Glu Lys Arg Glu   Ser Gly Thr 
    22400                 22405                 22410             


Thr Ala   Trp Gln Leu Val Asn   Ser Ser Val Lys Arg   Thr Gln Ile 
    22415                 22420                 22425             


Lys Val   Thr His Leu Thr Lys   Tyr Met Glu Tyr Ser   Phe Arg Val 
    22430                 22435                 22440             


Ser Ser   Glu Asn Arg Phe Gly   Val Ser Lys Pro Leu   Glu Ser Ala 
    22445                 22450                 22455             


Pro Ile   Ile Ala Glu His Pro   Phe Val Pro Pro Ser   Ala Pro Thr 
    22460                 22465                 22470             


Arg Pro   Glu Val Tyr His Val   Ser Ala Asn Ala Met   Ser Ile Arg 
    22475                 22480                 22485             


Trp Glu   Glu Pro Tyr His Asp   Gly Gly Ser Lys Ile   Ile Gly Tyr 
    22490                 22495                 22500             


Trp Val   Glu Lys Lys Glu Arg   Asn Thr Ile Leu Trp   Val Lys Glu 
    22505                 22510                 22515             


Asn Lys   Val Pro Cys Leu Glu   Cys Asn Tyr Lys Val   Thr Gly Leu 
    22520                 22525                 22530             


Val Glu   Gly Leu Glu Tyr Gln   Phe Arg Thr Tyr Ala   Leu Asn Ala 
    22535                 22540                 22545             


Ala Gly   Val Ser Lys Ala Ser   Glu Ala Ser Arg Pro   Ile Met Ala 
    22550                 22555                 22560             


Gln Asn   Pro Val Asp Ala Pro   Gly Arg Pro Glu Val   Thr Asp Val 
    22565                 22570                 22575             


Thr Arg   Ser Thr Val Ser Leu   Ile Trp Ser Ala Pro   Ala Tyr Asp 
    22580                 22585                 22590             


Gly Gly   Ser Lys Val Val Gly   Tyr Ile Ile Glu Arg   Lys Pro Val 
    22595                 22600                 22605             


Ser Glu   Val Gly Asp Gly Arg   Trp Leu Lys Cys Asn   Tyr Thr Ile 
    22610                 22615                 22620             


Val Ser   Asp Asn Phe Phe Thr   Val Thr Ala Leu Ser   Glu Gly Asp 
    22625                 22630                 22635             


Thr Tyr   Glu Phe Arg Val Leu   Ala Lys Asn Ala Ala   Gly Val Ile 
    22640                 22645                 22650             


Ser Lys   Gly Ser Glu Ser Thr   Gly Pro Val Thr Cys   Arg Asp Glu 
    22655                 22660                 22665             


Tyr Ala   Pro Pro Lys Ala Glu   Leu Asp Ala Arg Leu   His Gly Asp 
    22670                 22675                 22680             


Leu Val   Thr Ile Arg Ala Gly   Ser Asp Leu Val Leu   Asp Ala Ala 
    22685                 22690                 22695             


Val Gly   Gly Lys Pro Glu Pro   Lys Ile Ile Trp Thr   Lys Gly Asp 
    22700                 22705                 22710             


Lys Glu   Leu Asp Leu Cys Glu   Lys Val Ser Leu Gln   Tyr Thr Gly 
    22715                 22720                 22725             


Lys Arg   Ala Thr Ala Val Ile   Lys Phe Cys Asp Arg   Ser Asp Ser 
    22730                 22735                 22740             


Gly Lys   Tyr Thr Leu Thr Val   Lys Asn Ala Ser Gly   Thr Lys Ala 
    22745                 22750                 22755             


Val Ser   Val Met Val Lys Val   Leu Asp Ser Pro Gly   Pro Cys Gly 
    22760                 22765                 22770             


Lys Leu   Thr Val Ser Arg Val   Thr Gln Glu Lys Cys   Thr Leu Ala 
    22775                 22780                 22785             


Trp Ser   Leu Pro Gln Glu Asp   Gly Gly Ala Glu Ile   Thr His Tyr 
    22790                 22795                 22800             


Ile Val   Glu Arg Arg Glu Thr   Ser Arg Leu Asn Trp   Val Ile Val 
    22805                 22810                 22815             


Glu Gly   Glu Cys Pro Thr Leu   Ser Tyr Val Val Thr   Arg Leu Ile 
    22820                 22825                 22830             


Lys Asn   Asn Glu Tyr Ile Phe   Arg Val Arg Ala Val   Asn Lys Tyr 
    22835                 22840                 22845             


Gly Pro   Gly Val Pro Val Glu   Ser Glu Pro Ile Val   Ala Arg Asn 
    22850                 22855                 22860             


Ser Phe   Thr Ile Pro Ser Pro   Pro Gly Ile Pro Glu   Glu Val Gly 
    22865                 22870                 22875             


Thr Gly   Lys Glu His Ile Ile   Ile Gln Trp Thr Lys   Pro Glu Ser 
    22880                 22885                 22890             


Asp Gly   Gly Asn Glu Ile Ser   Asn Tyr Leu Val Asp   Lys Arg Glu 
    22895                 22900                 22905             


Lys Lys   Ser Leu Arg Trp Thr   Arg Val Asn Lys Asp   Tyr Val Val 
    22910                 22915                 22920             


Tyr Asp   Thr Arg Leu Lys Val   Thr Ser Leu Met Glu   Gly Cys Asp 
    22925                 22930                 22935             


Tyr Gln   Phe Arg Val Thr Ala   Val Asn Ala Ala Gly   Asn Ser Glu 
    22940                 22945                 22950             


Pro Ser   Glu Ala Ser Asn Phe   Ile Ser Cys Arg Glu   Pro Ser Tyr 
    22955                 22960                 22965             


Thr Pro   Gly Pro Pro Ser Ala   Pro Arg Val Val Asp   Thr Thr Lys 
    22970                 22975                 22980             


His Ser   Ile Ser Leu Ala Trp   Thr Lys Pro Met Tyr   Asp Gly Gly 
    22985                 22990                 22995             


Thr Asp   Ile Val Gly Tyr Val   Leu Glu Met Gln Glu   Lys Asp Thr 
    23000                 23005                 23010             


Asp Gln   Trp Tyr Arg Val His   Thr Asn Ala Thr Ile   Arg Asn Thr 
    23015                 23020                 23025             


Glu Phe   Thr Val Pro Asp Leu   Lys Met Gly Gln Lys   Tyr Ser Phe 
    23030                 23035                 23040             


Arg Val   Ala Ala Val Asn Val   Lys Gly Met Ser Glu   Tyr Ser Glu 
    23045                 23050                 23055             


Ser Ile   Ala Glu Ile Glu Pro   Val Glu Arg Ile Glu   Ile Pro Asp 
    23060                 23065                 23070             


Leu Glu   Leu Ala Asp Asp Leu   Lys Lys Thr Val Thr   Ile Arg Ala 
    23075                 23080                 23085             


Gly Ala   Ser Leu Arg Leu Met   Val Ser Val Ser Gly   Arg Pro Pro 
    23090                 23095                 23100             


Pro Val   Ile Thr Trp Ser Lys   Gln Gly Ile Asp Leu   Ala Ser Arg 
    23105                 23110                 23115             


Ala Ile   Ile Asp Thr Thr Glu   Ser Tyr Ser Leu Leu   Ile Val Asp 
    23120                 23125                 23130             


Lys Val   Asn Arg Tyr Asp Ala   Gly Lys Tyr Thr Ile   Glu Ala Glu 
    23135                 23140                 23145             


Asn Gln   Ser Gly Lys Lys Ser   Ala Thr Val Leu Val   Lys Val Tyr 
    23150                 23155                 23160             


Asp Thr   Pro Gly Pro Cys Pro   Ser Val Lys Val Lys   Glu Val Ser 
    23165                 23170                 23175             


Arg Asp   Ser Val Thr Ile Thr   Trp Glu Ile Pro Thr   Ile Asp Gly 
    23180                 23185                 23190             


Gly Ala   Pro Val Asn Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Ala 
    23195                 23200                 23205             


Met Arg   Ala Phe Lys Thr Val   Thr Thr Lys Cys Ser   Lys Thr Leu 
    23210                 23215                 23220             


Tyr Arg   Ile Ser Gly Leu Val   Glu Gly Thr Met Tyr   Tyr Phe Arg 
    23225                 23230                 23235             


Val Leu   Pro Glu Asn Ile Tyr   Gly Ile Gly Glu Pro   Cys Glu Thr 
    23240                 23245                 23250             


Ser Asp   Ala Val Leu Val Ser   Glu Val Pro Leu Val   Pro Ala Lys 
    23255                 23260                 23265             


Leu Glu   Val Val Asp Val Thr   Lys Ser Thr Val Thr   Leu Ala Trp 
    23270                 23275                 23280             


Glu Lys   Pro Leu Tyr Asp Gly   Gly Ser Arg Leu Thr   Gly Tyr Val 
    23285                 23290                 23295             


Leu Glu   Ala Cys Lys Ala Gly   Thr Glu Arg Trp Met   Lys Val Val 
    23300                 23305                 23310             


Thr Leu   Lys Pro Thr Val Leu   Glu His Thr Val Thr   Ser Leu Asn 
    23315                 23320                 23325             


Glu Gly   Glu Gln Tyr Leu Phe   Arg Ile Arg Ala Gln   Asn Glu Lys 
    23330                 23335                 23340             


Gly Val   Ser Glu Pro Arg Glu   Thr Val Thr Ala Val   Thr Val Gln 
    23345                 23350                 23355             


Asp Leu   Arg Val Leu Pro Thr   Ile Asp Leu Ser Thr   Met Pro Gln 
    23360                 23365                 23370             


Lys Thr   Ile His Val Pro Ala   Gly Arg Pro Val Glu   Leu Val Ile 
    23375                 23380                 23385             


Pro Ile   Ala Gly Arg Pro Pro   Pro Ala Ala Ser Trp   Phe Phe Ala 
    23390                 23395                 23400             


Gly Ser   Lys Leu Arg Glu Ser   Glu Arg Val Thr Val   Glu Thr His 
    23405                 23410                 23415             


Thr Lys   Val Ala Lys Leu Thr   Ile Arg Glu Thr Thr   Ile Arg Asp 
    23420                 23425                 23430             


Thr Gly   Glu Tyr Thr Leu Glu   Leu Lys Asn Val Thr   Gly Thr Thr 
    23435                 23440                 23445             


Ser Glu   Thr Ile Lys Val Ile   Ile Leu Asp Lys Pro   Gly Pro Pro 
    23450                 23455                 23460             


Thr Gly   Pro Ile Lys Ile Asp   Glu Ile Asp Ala Thr   Ser Ile Thr 
    23465                 23470                 23475             


Ile Ser   Trp Glu Pro Pro Glu   Leu Asp Gly Gly Ala   Pro Leu Ser 
    23480                 23485                 23490             


Gly Tyr   Val Val Glu Gln Arg   Asp Ala His Arg Pro   Gly Trp Leu 
    23495                 23500                 23505             


Pro Val   Ser Glu Ser Val Thr   Arg Ser Thr Phe Lys   Phe Thr Arg 
    23510                 23515                 23520             


Leu Thr   Glu Gly Asn Glu Tyr   Val Phe Arg Val Ala   Ala Thr Asn 
    23525                 23530                 23535             


Arg Phe   Gly Ile Gly Ser Tyr   Leu Gln Ser Glu Val   Ile Glu Cys 
    23540                 23545                 23550             


Arg Ser   Ser Ile Arg Ile Pro   Gly Pro Pro Glu Thr   Leu Gln Ile 
    23555                 23560                 23565             


Phe Asp   Val Ser Arg Asp Gly   Met Thr Leu Thr Trp   Tyr Pro Pro 
    23570                 23575                 23580             


Glu Asp   Asp Gly Gly Ser Gln   Val Thr Gly Tyr Ile   Val Glu Arg 
    23585                 23590                 23595             


Lys Glu   Val Arg Ala Asp Arg   Trp Val Arg Val Asn   Lys Val Pro 
    23600                 23605                 23610             


Val Thr   Met Thr Arg Tyr Arg   Ser Thr Gly Leu Thr   Glu Gly Leu 
    23615                 23620                 23625             


Glu Tyr   Glu His Arg Val Thr   Ala Ile Asn Ala Arg   Gly Ser Gly 
    23630                 23635                 23640             


Lys Pro   Ser Arg Pro Ser Lys   Pro Ile Val Ala Met   Asp Pro Ile 
    23645                 23650                 23655             


Ala Pro   Pro Gly Lys Pro Gln   Asn Pro Arg Val Thr   Asp Thr Thr 
    23660                 23665                 23670             


Arg Thr   Ser Val Ser Leu Ala   Trp Ser Val Pro Glu   Asp Glu Gly 
    23675                 23680                 23685             


Gly Ser   Lys Val Thr Gly Tyr   Leu Ile Glu Met Gln   Lys Val Asp 
    23690                 23695                 23700             


Gln His   Glu Trp Thr Lys Cys   Asn Thr Thr Pro Thr   Lys Ile Arg 
    23705                 23710                 23715             


Glu Tyr   Thr Leu Thr His Leu   Pro Gln Gly Ala Glu   Tyr Arg Phe 
    23720                 23725                 23730             


Arg Val   Leu Ala Cys Asn Ala   Gly Gly Pro Gly Glu   Pro Ala Glu 
    23735                 23740                 23745             


Val Pro   Gly Thr Val Lys Val   Thr Glu Met Leu Glu   Tyr Pro Asp 
    23750                 23755                 23760             


Tyr Glu   Leu Asp Glu Arg Tyr   Gln Glu Gly Ile Phe   Val Arg Gln 
    23765                 23770                 23775             


Gly Gly   Val Ile Arg Leu Thr   Ile Pro Ile Lys Gly   Lys Pro Phe 
    23780                 23785                 23790             


Pro Ile   Cys Lys Trp Thr Lys   Glu Gly Gln Asp Ile   Ser Lys Arg 
    23795                 23800                 23805             


Ala Met   Ile Ala Thr Ser Glu   Thr His Thr Glu Leu   Val Ile Lys 
    23810                 23815                 23820             


Glu Ala   Asp Arg Gly Asp Ser   Gly Thr Tyr Asp Leu   Val Leu Glu 
    23825                 23830                 23835             


Asn Lys   Cys Gly Lys Lys Ala   Val Tyr Ile Lys Val   Arg Val Ile 
    23840                 23845                 23850             


Gly Ser   Pro Asn Ser Pro Glu   Gly Pro Leu Glu Tyr   Asp Asp Ile 
    23855                 23860                 23865             


Gln Val   Arg Ser Val Arg Val   Ser Trp Arg Pro Pro   Ala Asp Asp 
    23870                 23875                 23880             


Gly Gly   Ala Asp Ile Leu Gly   Tyr Ile Leu Glu Arg   Arg Glu Val 
    23885                 23890                 23895             


Pro Lys   Ala Ala Trp Tyr Thr   Ile Asp Ser Arg Val   Arg Gly Thr 
    23900                 23905                 23910             


Ser Leu   Val Val Lys Gly Leu   Lys Glu Asn Val Glu   Tyr His Phe 
    23915                 23920                 23925             


Arg Val   Ser Ala Glu Asn Gln   Phe Gly Ile Ser Lys   Pro Leu Lys 
    23930                 23935                 23940             


Ser Glu   Glu Pro Val Thr Pro   Lys Thr Pro Leu Asn   Pro Pro Glu 
    23945                 23950                 23955             


Pro Pro   Ser Asn Pro Pro Glu   Val Leu Asp Val Thr   Lys Ser Ser 
    23960                 23965                 23970             


Val Ser   Leu Ser Trp Ser Arg   Pro Lys Asp Asp Gly   Gly Ser Arg 
    23975                 23980                 23985             


Val Thr   Gly Tyr Tyr Ile Glu   Arg Lys Glu Thr Ser   Thr Asp Lys 
    23990                 23995                 24000             


Trp Val   Arg His Asn Lys Thr   Gln Ile Thr Thr Thr   Met Tyr Thr 
    24005                 24010                 24015             


Val Thr   Gly Leu Val Pro Asp   Ala Glu Tyr Gln Phe   Arg Ile Ile 
    24020                 24025                 24030             


Ala Gln   Asn Asp Val Gly Leu   Ser Glu Thr Ser Pro   Ala Ser Glu 
    24035                 24040                 24045             


Pro Val   Val Cys Lys Asp Pro   Phe Asp Lys Pro Ser   Gln Pro Gly 
    24050                 24055                 24060             


Glu Leu   Glu Ile Leu Ser Ile   Ser Lys Asp Ser Val   Thr Leu Gln 
    24065                 24070                 24075             


Trp Glu   Lys Pro Glu Cys Asp   Gly Gly Lys Glu Ile   Leu Gly Tyr 
    24080                 24085                 24090             


Trp Val   Glu Tyr Arg Gln Ser   Gly Asp Ser Ala Trp   Lys Lys Ser 
    24095                 24100                 24105             


Asn Lys   Glu Arg Ile Lys Asp   Lys Gln Phe Thr Ile   Gly Gly Leu 
    24110                 24115                 24120             


Leu Glu   Ala Thr Glu Tyr Glu   Phe Arg Val Phe Ala   Glu Asn Glu 
    24125                 24130                 24135             


Thr Gly   Leu Ser Arg Pro Arg   Arg Thr Ala Met Ser   Ile Lys Thr 
    24140                 24145                 24150             


Lys Leu   Thr Ser Gly Glu Ala   Pro Gly Ile Arg Lys   Glu Met Lys 
    24155                 24160                 24165             


Asp Val   Thr Thr Lys Leu Gly   Glu Ala Ala Gln Leu   Ser Cys Gln 
    24170                 24175                 24180             


Ile Val   Gly Arg Pro Leu Pro   Asp Ile Lys Trp Tyr   Arg Phe Gly 
    24185                 24190                 24195             


Lys Glu   Leu Ile Gln Ser Arg   Lys Tyr Lys Met Ser   Ser Asp Gly 
    24200                 24205                 24210             


Arg Thr   His Thr Leu Thr Val   Met Thr Glu Glu Gln   Glu Asp Glu 
    24215                 24220                 24225             


Gly Val   Tyr Thr Cys Ile Ala   Thr Asn Glu Val Gly   Glu Val Glu 
    24230                 24235                 24240             


Thr Ser   Ser Lys Leu Leu Leu   Gln Ala Thr Pro Gln   Phe His Pro 
    24245                 24250                 24255             


Gly Tyr   Pro Leu Lys Glu Lys   Tyr Tyr Gly Ala Val   Gly Ser Thr 
    24260                 24265                 24270             


Leu Arg   Leu His Val Met Tyr   Ile Gly Arg Pro Val   Pro Ala Met 
    24275                 24280                 24285             


Thr Trp   Phe His Gly Gln Lys   Leu Leu Gln Asn Ser   Glu Asn Ile 
    24290                 24295                 24300             


Thr Ile   Glu Asn Thr Glu His   Tyr Thr His Leu Val   Met Lys Asn 
    24305                 24310                 24315             


Val Gln   Arg Lys Thr His Ala   Gly Lys Tyr Lys Val   Gln Leu Ser 
    24320                 24325                 24330             


Asn Val   Phe Gly Thr Val Asp   Ala Ile Leu Asp Val   Glu Ile Gln 
    24335                 24340                 24345             


Asp Lys   Pro Asp Lys Pro Thr   Gly Pro Ile Val Ile   Glu Ala Leu 
    24350                 24355                 24360             


Leu Lys   Asn Ser Ala Val Ile   Ser Trp Lys Pro Pro   Ala Asp Asp 
    24365                 24370                 24375             


Gly Gly   Ser Trp Ile Thr Asn   Tyr Val Val Glu Lys   Cys Glu Ala 
    24380                 24385                 24390             


Lys Glu   Gly Ala Glu Trp Gln   Leu Val Ser Ser Ala   Ile Ser Val 
    24395                 24400                 24405             


Thr Thr   Cys Arg Ile Val Asn   Leu Thr Glu Asn Ala   Gly Tyr Tyr 
    24410                 24415                 24420             


Phe Arg   Val Ser Ala Gln Asn   Thr Phe Gly Ile Ser   Asp Pro Leu 
    24425                 24430                 24435             


Glu Val   Ser Ser Val Val Ile   Ile Lys Ser Pro Phe   Glu Lys Pro 
    24440                 24445                 24450             


Gly Ala   Pro Gly Lys Pro Thr   Ile Thr Ala Val Thr   Lys Asp Ser 
    24455                 24460                 24465             


Cys Val   Val Ala Trp Lys Pro   Pro Ala Ser Asp Gly   Gly Ala Lys 
    24470                 24475                 24480             


Ile Arg   Asn Tyr Tyr Leu Glu   Lys Arg Glu Lys Lys   Gln Asn Lys 
    24485                 24490                 24495             


Trp Ile   Ser Val Thr Thr Glu   Glu Ile Arg Glu Thr   Val Phe Ser 
    24500                 24505                 24510             


Val Lys   Asn Leu Ile Glu Gly   Leu Glu Tyr Glu Phe   Arg Val Lys 
    24515                 24520                 24525             


Cys Glu   Asn Leu Gly Gly Glu   Ser Glu Trp Ser Glu   Ile Ser Glu 
    24530                 24535                 24540             


Pro Ile   Thr Pro Lys Ser Asp   Val Pro Ile Gln Ala   Pro His Phe 
    24545                 24550                 24555             


Lys Glu   Glu Leu Arg Asn Leu   Asn Val Arg Tyr Gln   Ser Asn Ala 
    24560                 24565                 24570             


Thr Leu   Val Cys Lys Val Thr   Gly His Pro Lys Pro   Ile Val Lys 
    24575                 24580                 24585             


Trp Tyr   Arg Gln Gly Lys Glu   Ile Ile Ala Asp Gly   Leu Lys Tyr 
    24590                 24595                 24600             


Arg Ile   Gln Glu Phe Lys Gly   Gly Tyr His Gln Leu   Ile Ile Ala 
    24605                 24610                 24615             


Ser Val   Thr Asp Asp Asp Ala   Thr Val Tyr Gln Val   Arg Ala Thr 
    24620                 24625                 24630             


Asn Gln   Gly Gly Ser Val Ser   Gly Thr Ala Ser Leu   Glu Val Glu 
    24635                 24640                 24645             


Val Pro   Ala Lys Ile His Leu   Pro Lys Thr Leu Glu   Gly Met Gly 
    24650                 24655                 24660             


Ala Val   His Ala Leu Arg Gly   Glu Val Val Ser Ile   Lys Ile Pro 
    24665                 24670                 24675             


Phe Ser   Gly Lys Pro Asp Pro   Val Ile Thr Trp Gln   Lys Gly Gln 
    24680                 24685                 24690             


Asp Leu   Ile Asp Asn Asn Gly   His Tyr Gln Val Ile   Val Thr Arg 
    24695                 24700                 24705             


Ser Phe   Thr Ser Leu Val Phe   Pro Asn Gly Val Glu   Arg Lys Asp 
    24710                 24715                 24720             


Ala Gly   Phe Tyr Val Val Cys   Ala Lys Asn Arg Phe   Gly Ile Asp 
    24725                 24730                 24735             


Gln Lys   Thr Val Glu Leu Asp   Val Ala Asp Val Pro   Asp Pro Pro 
    24740                 24745                 24750             


Arg Gly   Val Lys Val Ser Asp   Val Ser Arg Asp Ser   Val Asn Leu 
    24755                 24760                 24765             


Thr Trp   Thr Glu Pro Ala Ser   Asp Gly Gly Ser Lys   Ile Thr Asn 
    24770                 24775                 24780             


Tyr Ile   Val Glu Lys Cys Ala   Thr Thr Ala Glu Arg   Trp Leu Arg 
    24785                 24790                 24795             


Val Gly   Gln Ala Arg Glu Thr   Arg Tyr Thr Val Ile   Asn Leu Phe 
    24800                 24805                 24810             


Gly Lys   Thr Ser Tyr Gln Phe   Arg Val Ile Ala Glu   Asn Lys Phe 
    24815                 24820                 24825             


Gly Leu   Ser Lys Pro Ser Glu   Pro Ser Glu Pro Thr   Ile Thr Lys 
    24830                 24835                 24840             


Glu Asp   Lys Thr Arg Ala Met   Asn Tyr Asp Glu Glu   Val Asp Glu 
    24845                 24850                 24855             


Thr Arg   Glu Val Ser Met Thr   Lys Ala Ser His Ser   Ser Thr Lys 
    24860                 24865                 24870             


Glu Leu   Tyr Glu Lys Tyr Met   Ile Ala Glu Asp Leu   Gly Arg Gly 
    24875                 24880                 24885             


Glu Phe   Gly Ile Val His Arg   Cys Val Glu Thr Ser   Ser Lys Lys 
    24890                 24895                 24900             


Thr Tyr   Met Ala Lys Phe Val   Lys Val Lys Gly Thr   Asp Gln Val 
    24905                 24910                 24915             


Leu Val   Lys Lys Glu Ile Ser   Ile Leu Asn Ile Ala   Arg His Arg 
    24920                 24925                 24930             


Asn Ile   Leu His Leu His Glu   Ser Phe Glu Ser Met   Glu Glu Leu 
    24935                 24940                 24945             


Val Met   Ile Phe Glu Phe Ile   Ser Gly Leu Asp Ile   Phe Glu Arg 
    24950                 24955                 24960             


Ile Asn   Thr Ser Ala Phe Glu   Leu Asn Glu Arg Glu   Ile Val Ser 
    24965                 24970                 24975             


Tyr Val   His Gln Val Cys Glu   Ala Leu Gln Phe Leu   His Ser His 
    24980                 24985                 24990             


Asn Ile   Gly His Phe Asp Ile   Arg Pro Glu Asn Ile   Ile Tyr Gln 
    24995                 25000                 25005             


Thr Arg   Arg Ser Ser Thr Ile   Lys Ile Ile Glu Phe   Gly Gln Ala 
    25010                 25015                 25020             


Arg Gln   Leu Lys Pro Gly Asp   Asn Phe Arg Leu Leu   Phe Thr Ala 
    25025                 25030                 25035             


Pro Glu   Tyr Tyr Ala Pro Glu   Val His Gln His Asp   Val Val Ser 
    25040                 25045                 25050             


Thr Ala   Thr Asp Met Trp Ser   Leu Gly Thr Leu Val   Tyr Val Leu 
    25055                 25060                 25065             


Leu Ser   Gly Ile Asn Pro Phe   Leu Ala Glu Thr Asn   Gln Gln Ile 
    25070                 25075                 25080             


Ile Glu   Asn Ile Met Asn Ala   Glu Tyr Thr Phe Asp   Glu Glu Ala 
    25085                 25090                 25095             


Phe Lys   Glu Ile Ser Ile Glu   Ala Met Asp Phe Val   Asp Arg Leu 
    25100                 25105                 25110             


Leu Val   Lys Glu Arg Lys Ser   Arg Met Thr Ala Ser   Glu Ala Leu 
    25115                 25120                 25125             


Gln His   Pro Trp Leu Lys Gln   Lys Ile Glu Arg Val   Ser Thr Lys 
    25130                 25135                 25140             


Val Ile   Arg Thr Leu Lys His   Arg Arg Tyr Tyr His   Thr Leu Ile 
    25145                 25150                 25155             


Lys Lys   Asp Leu Asn Met Val   Val Ser Ala Ala Arg   Ile Ser Cys 
    25160                 25165                 25170             


Gly Gly   Ala Ile Arg Ser Gln   Lys Gly Val Ser Val   Ala Lys Val 
    25175                 25180                 25185             


Lys Val   Ala Ser Ile Glu Ile   Gly Pro Val Ser Gly   Gln Ile Met 
    25190                 25195                 25200             


His Ala   Val Gly Glu Glu Gly   Gly His Val Lys Tyr   Val Cys Lys 
    25205                 25210                 25215             


Ile Glu   Asn Tyr Asp Gln Ser   Thr Gln Val Thr Trp   Tyr Phe Gly 
    25220                 25225                 25230             


Val Arg   Gln Leu Glu Asn Ser   Glu Lys Tyr Glu Ile   Thr Tyr Glu 
    25235                 25240                 25245             


Asp Gly   Val Ala Ile Leu Tyr   Val Lys Asp Ile Thr   Lys Leu Asp 
    25250                 25255                 25260             


Asp Gly   Thr Tyr Arg Cys Lys   Val Val Asn Asp Tyr   Gly Glu Asp 
    25265                 25270                 25275             


Ser Ser   Tyr Ala Glu Leu Phe   Val Lys Gly Val Arg   Glu Val Tyr 
    25280                 25285                 25290             


Asp Tyr   Tyr Cys Arg Arg Thr   Met Lys Lys Ile Lys   Arg Arg Thr 
    25295                 25300                 25305             


Asp Thr   Met Arg Leu Leu Glu   Arg Pro Pro Glu Phe   Thr Leu Pro 
    25310                 25315                 25320             


Leu Tyr   Asn Lys Thr Ala Tyr   Val Gly Glu Asn Val   Arg Phe Gly 
    25325                 25330                 25335             


Val Thr   Ile Thr Val His Pro   Glu Pro His Val Thr   Trp Tyr Lys 
    25340                 25345                 25350             


Ser Gly   Gln Lys Ile Lys Pro   Gly Asp Asn Asp Lys   Lys Tyr Thr 
    25355                 25360                 25365             


Phe Glu   Ser Asp Lys Gly Leu   Tyr Gln Leu Thr Ile   Asn Ser Val 
    25370                 25375                 25380             


Thr Thr   Asp Asp Asp Ala Glu   Tyr Thr Val Val Ala   Arg Asn Lys 
    25385                 25390                 25395             


Tyr Gly   Glu Asp Ser Cys Lys   Ala Lys Leu Thr Val   Thr Leu His 
    25400                 25405                 25410             


Pro Pro   Pro Thr Asp Ser Thr   Leu Arg Pro Met Phe   Lys Arg Leu 
    25415                 25420                 25425             


Leu Ala   Asn Ala Glu Cys Gln   Glu Gly Gln Ser Val   Cys Phe Glu 
    25430                 25435                 25440             


Ile Arg   Val Ser Gly Ile Pro   Pro Pro Thr Leu Lys   Trp Glu Lys 
    25445                 25450                 25455             


Asp Gly   Gln Pro Leu Ser Leu   Gly Pro Asn Ile Glu   Ile Ile His 
    25460                 25465                 25470             


Glu Gly   Leu Asp Tyr Tyr Ala   Leu His Ile Arg Asp   Thr Leu Pro 
    25475                 25480                 25485             


Glu Asp   Thr Gly Tyr Tyr Arg   Val Thr Ala Thr Asn   Thr Ala Gly 
    25490                 25495                 25500             


Ser Thr   Ser Cys Gln Ala His   Leu Gln Val Glu Arg   Leu Arg Tyr 
    25505                 25510                 25515             


Lys Lys   Gln Glu Phe Lys Ser   Lys Glu Glu His Glu   Arg His Val 
    25520                 25525                 25530             


Gln Lys   Gln Ile Asp Lys Thr   Leu Arg Met Ala Glu   Ile Leu Ser 
    25535                 25540                 25545             


Gly Thr   Glu Ser Val Pro Leu   Thr Gln Val Ala Lys   Glu Ala Leu 
    25550                 25555                 25560             


Arg Glu   Ala Ala Val Leu Tyr   Lys Pro Ala Val Ser   Thr Lys Thr 
    25565                 25570                 25575             


Val Lys   Gly Glu Phe Arg Leu   Glu Ile Glu Glu Lys   Lys Glu Glu 
    25580                 25585                 25590             


Arg Lys   Leu Arg Met Pro Tyr   Asp Val Pro Glu Pro   Arg Lys Tyr 
    25595                 25600                 25605             


Lys Gln   Thr Thr Ile Glu Glu   Asp Gln Arg Ile Lys   Gln Phe Val 
    25610                 25615                 25620             


Pro Met   Ser Asp Met Lys Trp   Tyr Lys Lys Ile Arg   Asp Gln Tyr 
    25625                 25630                 25635             


Glu Met   Pro Gly Lys Leu Asp   Arg Val Val Gln Lys   Arg Pro Lys 
    25640                 25645                 25650             


Arg Ile   Arg Leu Ser Arg Trp   Glu Gln Phe Tyr Val   Met Pro Leu 
    25655                 25660                 25665             


Pro Arg   Ile Thr Asp Gln Tyr   Arg Pro Lys Trp Arg   Ile Pro Lys 
    25670                 25675                 25680             


Leu Ser   Gln Asp Asp Leu Glu   Ile Val Arg Pro Ala   Arg Arg Arg 
    25685                 25690                 25695             


Thr Pro   Ser Pro Asp Tyr Asp   Phe Tyr Tyr Arg Pro   Arg Arg Arg 
    25700                 25705                 25710             


Ser Leu   Gly Asp Ile Ser Asp   Glu Glu Leu Leu Leu   Pro Ile Asp 
    25715                 25720                 25725             


Asp Tyr   Leu Ala Met Lys Arg   Thr Glu Glu Glu Arg   Leu Arg Leu 
    25730                 25735                 25740             


Glu Glu   Glu Leu Glu Leu Gly   Phe Ser Ala Ser Pro   Pro Ser Arg 
    25745                 25750                 25755             


Ser Pro   Pro His Phe Glu Leu   Ser Ser Leu Arg Tyr   Ser Ser Pro 
    25760                 25765                 25770             


Gln Ala   His Val Lys Val Glu   Glu Thr Arg Lys Asp   Phe Arg Tyr 
    25775                 25780                 25785             


Ser Thr   Tyr His Ile Pro Thr   Lys Ala Glu Ala Ser   Thr Ser Tyr 
    25790                 25795                 25800             


Ala Glu   Leu Arg Glu Arg His   Ala Gln Ala Ala Tyr   Arg Gln Pro 
    25805                 25810                 25815             


Lys Gln   Arg Gln Arg Ile Met   Ala Glu Arg Glu Asp   Glu Glu Leu 
    25820                 25825                 25830             


Leu Arg   Pro Val Thr Thr Thr   Gln His Leu Ser Glu   Tyr Lys Ser 
    25835                 25840                 25845             


Glu Leu   Asp Phe Met Ser Lys   Glu Glu Lys Ser Arg   Lys Lys Ser 
    25850                 25855                 25860             


Arg Arg   Gln Arg Glu Val Thr   Glu Ile Thr Glu Ile   Glu Glu Glu 
    25865                 25870                 25875             


Tyr Glu   Ile Ser Lys His Ala   Gln Arg Glu Ser Ser   Ser Ser Ala 
    25880                 25885                 25890             


Ser Arg   Leu Leu Arg Arg Arg   Arg Ser Leu Ser Pro   Thr Tyr Ile 
    25895                 25900                 25905             


Glu Leu   Met Arg Pro Val Ser   Glu Leu Ile Arg Ser   Arg Pro Gln 
    25910                 25915                 25920             


Pro Ala   Glu Glu Tyr Glu Asp   Asp Thr Glu Arg Arg   Ser Pro Thr 
    25925                 25930                 25935             


Pro Glu   Arg Thr Arg Pro Arg   Ser Pro Ser Pro Val   Ser Ser Glu 
    25940                 25945                 25950             


Arg Ser   Leu Ser Arg Phe Glu   Arg Ser Ala Arg Phe   Asp Ile Phe 
    25955                 25960                 25965             


Ser Arg   Tyr Glu Ser Met Lys   Ala Ala Leu Lys Thr   Gln Lys Thr 
    25970                 25975                 25980             


Ser Glu   Arg Lys Tyr Glu Val   Leu Ser Gln Gln Pro   Phe Thr Leu 
    25985                 25990                 25995             


Asp His   Ala Pro Arg Ile Thr   Leu Arg Met Arg Ser   His Arg Val 
    26000                 26005                 26010             


Pro Cys   Gly Gln Asn Thr Arg   Phe Ile Leu Asn Val   Gln Ser Lys 
    26015                 26020                 26025             


Pro Thr   Ala Glu Val Lys Trp   Tyr His Asn Gly Val   Glu Leu Gln 
    26030                 26035                 26040             


Glu Ser   Ser Lys Ile His Tyr   Thr Asn Thr Ser Gly   Val Leu Thr 
    26045                 26050                 26055             


Leu Glu   Ile Leu Asp Cys His   Thr Asp Asp Ser Gly   Thr Tyr Arg 
    26060                 26065                 26070             


Ala Val   Cys Thr Asn Tyr Lys   Gly Glu Ala Ser Asp   Tyr Ala Thr 
    26075                 26080                 26085             


Leu Asp   Val Thr Gly Gly Asp   Tyr Thr Thr Tyr Ala   Ser Gln Arg 
    26090                 26095                 26100             


Arg Asp   Glu Glu Val Pro Arg   Ser Val Phe Pro Glu   Leu Thr Arg 
    26105                 26110                 26115             


Thr Glu   Ala Tyr Ala Val Ser   Ser Phe Lys Lys Thr   Ser Glu Met 
    26120                 26125                 26130             


Glu Ala   Ser Ser Ser Val Arg   Glu Val Lys Ser Gln   Met Thr Glu 
    26135                 26140                 26145             


Thr Arg   Glu Ser Leu Ser Ser   Tyr Glu His Ser Ala   Ser Ala Glu 
    26150                 26155                 26160             


Met Lys   Ser Ala Ala Leu Glu   Glu Lys Ser Leu Glu   Glu Lys Ser 
    26165                 26170                 26175             


Thr Thr   Arg Lys Ile Lys Thr   Thr Leu Ala Ala Arg   Ile Leu Thr 
    26180                 26185                 26190             


Lys Pro   Arg Ser Met Thr Val   Tyr Glu Gly Glu Ser   Ala Arg Phe 
    26195                 26200                 26205             


Ser Cys   Asp Thr Asp Gly Glu   Pro Val Pro Thr Val   Thr Trp Leu 
    26210                 26215                 26220             


Arg Lys   Gly Gln Val Leu Ser   Thr Ser Ala Arg His   Gln Val Thr 
    26225                 26230                 26235             


Thr Thr   Lys Tyr Lys Ser Thr   Phe Glu Ile Ser Ser   Val Gln Ala 
    26240                 26245                 26250             


Ser Asp   Glu Gly Asn Tyr Ser   Val Val Val Glu Asn   Ser Glu Gly 
    26255                 26260                 26265             


Lys Gln   Glu Ala Glu Phe Thr   Leu Thr Ile Gln Lys   Ala Arg Val 
    26270                 26275                 26280             


Thr Glu   Lys Ala Val Thr Ser   Pro Pro Arg Val Lys   Ser Pro Glu 
    26285                 26290                 26295             


Pro Arg   Val Lys Ser Pro Glu   Ala Val Lys Ser Pro   Lys Arg Val 
    26300                 26305                 26310             


Lys Ser   Pro Glu Pro Ser His   Pro Lys Ala Val Ser   Pro Thr Glu 
    26315                 26320                 26325             


Thr Lys   Pro Thr Pro Thr Glu   Lys Val Gln His Leu   Pro Val Ser 
    26330                 26335                 26340             


Ala Pro   Pro Lys Ile Thr Gln   Phe Leu Lys Ala Glu   Ala Ser Lys 
    26345                 26350                 26355             


Glu Ile   Ala Lys Leu Thr Cys   Val Val Glu Ser Ser   Val Leu Arg 
    26360                 26365                 26370             


Ala Lys   Glu Val Thr Trp Tyr   Lys Asp Gly Lys Lys   Leu Lys Glu 
    26375                 26380                 26385             


Asn Gly   His Phe Gln Phe His   Tyr Ser Ala Asp Gly   Thr Tyr Glu 
    26390                 26395                 26400             


Leu Lys   Ile Asn Asn Leu Thr   Glu Ser Asp Gln Gly   Glu Tyr Val 
    26405                 26410                 26415             


Cys Glu   Ile Ser Gly Glu Gly   Gly Thr Ser Lys Thr   Asn Leu Gln 
    26420                 26425                 26430             


Phe Met   Gly Gln Ala Phe Lys   Ser Ile His Glu Lys   Val Ser Lys 
    26435                 26440                 26445             


Ile Ser   Glu Thr Lys Lys Ser   Asp Gln Lys Thr Thr   Glu Ser Thr 
    26450                 26455                 26460             


Val Thr   Arg Lys Thr Glu Pro   Lys Ala Pro Glu Pro   Ile Ser Ser 
    26465                 26470                 26475             


Lys Pro   Val Ile Val Thr Gly   Leu Gln Asp Thr Thr   Val Ser Ser 
    26480                 26485                 26490             


Asp Ser   Val Ala Lys Phe Ala   Val Lys Ala Thr Gly   Glu Pro Arg 
    26495                 26500                 26505             


Pro Thr   Ala Ile Trp Thr Lys   Asp Gly Lys Ala Ile   Thr Gln Gly 
    26510                 26515                 26520             


Gly Lys   Tyr Lys Leu Ser Glu   Asp Lys Gly Gly Phe   Phe Leu Glu 
    26525                 26530                 26535             


Ile His   Lys Thr Asp Thr Ser   Asp Ser Gly Leu Tyr   Thr Cys Thr 
    26540                 26545                 26550             


Val Lys   Asn Ser Ala Gly Ser   Val Ser Ser Ser Cys   Lys Leu Thr 
    26555                 26560                 26565             


Ile Lys   Ala Ile Lys Asp Thr   Glu Ala Gln Lys Val   Ser Thr Gln 
    26570                 26575                 26580             


Lys Thr   Ser Glu Ile Thr Pro   Gln Lys Lys Ala Val   Val Gln Glu 
    26585                 26590                 26595             


Glu Ile   Ser Gln Lys Ala Leu   Arg Ser Glu Glu Ile   Lys Met Ser 
    26600                 26605                 26610             


Glu Ala   Lys Ser Gln Glu Lys   Leu Ala Leu Lys Glu   Glu Ala Ser 
    26615                 26620                 26625             


Lys Val   Leu Ile Ser Glu Glu   Val Lys Lys Ser Ala   Ala Thr Ser 
    26630                 26635                 26640             


Leu Glu   Lys Ser Ile Val His   Glu Glu Ile Thr Lys   Thr Ser Gln 
    26645                 26650                 26655             


Ala Ser   Glu Glu Val Arg Thr   His Ala Glu Ile Lys   Ala Phe Ser 
    26660                 26665                 26670             


Thr Gln   Met Ser Ile Asn Glu   Gly Gln Arg Leu Val   Leu Lys Ala 
    26675                 26680                 26685             


Asn Ile   Ala Gly Ala Thr Asp   Val Lys Trp Val Leu   Asn Gly Val 
    26690                 26695                 26700             


Glu Leu   Thr Asn Ser Glu Glu   Tyr Arg Tyr Gly Val   Ser Gly Ser 
    26705                 26710                 26715             


Asp Gln   Thr Leu Thr Ile Lys   Gln Ala Ser His Arg   Asp Glu Gly 
    26720                 26725                 26730             


Ile Leu   Thr Cys Ile Ser Lys   Thr Lys Glu Gly Ile   Val Lys Cys 
    26735                 26740                 26745             


Gln Tyr   Asp Leu Thr Leu Ser   Lys Glu Leu Ser Asp   Ala Pro Ala 
    26750                 26755                 26760             


Phe Ile   Ser Gln Pro Arg Ser   Gln Asn Ile Asn Glu   Gly Gln Asn 
    26765                 26770                 26775             


Val Leu   Phe Thr Cys Glu Ile   Ser Gly Glu Pro Ser   Pro Glu Ile 
    26780                 26785                 26790             


Glu Trp   Phe Lys Asn Asn Leu   Pro Ile Ser Ile Ser   Ser Asn Val 
    26795                 26800                 26805             


Ser Ile   Ser Arg Ser Arg Asn   Val Tyr Ser Leu Glu   Ile Arg Asn 
    26810                 26815                 26820             


Ala Ser   Val Ser Asp Ser Gly   Lys Tyr Thr Ile Lys   Ala Lys Asn 
    26825                 26830                 26835             


Phe Arg   Gly Gln Cys Ser Ala   Thr Ala Ser Leu Met   Val Leu Pro 
    26840                 26845                 26850             


Leu Val   Glu Glu Pro Ser Arg   Glu Val Val Leu Arg   Thr Ser Gly 
    26855                 26860                 26865             


Asp Thr   Ser Leu Gln Gly Ser   Phe Ser Ser Gln Ser   Val Gln Met 
    26870                 26875                 26880             


Ser Ala   Ser Lys Gln Glu Ala   Ser Phe Ser Ser Phe   Ser Ser Ser 
    26885                 26890                 26895             


Ser Ala   Ser Ser Met Thr Glu   Met Lys Phe Ala Ser   Met Ser Ala 
    26900                 26905                 26910             


Gln Ser   Met Ser Ser Met Gln   Glu Ser Phe Val Glu   Met Ser Ser 
    26915                 26920                 26925             


Ser Ser   Phe Met Gly Ile Ser   Asn Met Thr Gln Leu   Glu Ser Ser 
    26930                 26935                 26940             


Thr Ser   Lys Met Leu Lys Ala   Gly Ile Arg Gly Ile   Pro Pro Lys 
    26945                 26950                 26955             


Ile Glu   Ala Leu Pro Ser Asp   Ile Ser Ile Asp Glu   Gly Lys Val 
    26960                 26965                 26970             


Leu Thr   Val Ala Cys Ala Phe   Thr Gly Glu Pro Thr   Pro Glu Val 
    26975                 26980                 26985             


Thr Trp   Ser Cys Gly Gly Arg   Lys Ile His Ser Gln   Glu Gln Gly 
    26990                 26995                 27000             


Arg Phe   His Ile Glu Asn Thr   Asp Asp Leu Thr Thr   Leu Ile Ile 
    27005                 27010                 27015             


Met Asp   Val Gln Lys Gln Asp   Gly Gly Leu Tyr Thr   Leu Ser Leu 
    27020                 27025                 27030             


Gly Asn   Glu Phe Gly Ser Asp   Ser Ala Thr Val Asn   Ile His Ile 
    27035                 27040                 27045             


Arg Ser   Ile 
    27050     


<210>  7664
<211>  34350
<212>  PRT
<213>  Homo sapiens

<400>  7664

Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro His Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Arg Gln Glu Thr Glu 
545                 550                 555                 560 


Ile Thr Ala Ala Ser Met Val Val Val Ala Thr Ala Lys Ser Thr Lys 
                565                 570                 575     


Leu Glu Thr Val Pro Gly Ala Gln Glu Glu Thr Thr Thr Gln Gln Asp 
            580                 585                 590         


Gln Met His Leu Ser Tyr Glu Lys Ile Met Lys Glu Thr Arg Lys Thr 
        595                 600                 605             


Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu Gln Asp 
    610                 615                 620                 


Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu Gln Val 
625                 630                 635                 640 


Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr Ala Leu 
                645                 650                 655     


Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu Thr Ile 
            660                 665                 670         


Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile Gln Val 
        675                 680                 685             


Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val Ala Thr 
    690                 695                 700                 


Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg Glu Pro 
705                 710                 715                 720 


Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu Tyr Gly 
                725                 730                 735     


Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro Gln Arg 
            740                 745                 750         


Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro Arg Val 
        755                 760                 765             


Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln Lys Gly 
    770                 775                 780                 


Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr Thr Glu 
785                 790                 795                 800 


Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro His Phe 
                805                 810                 815     


Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr Glu Ala 
            820                 825                 830         


Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu Ser Ala 
        835                 840                 845             


Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro Thr Val 
    850                 855                 860                 


Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu Pro Gln 
865                 870                 875                 880 


Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala Gly Val 
                885                 890                 895     


Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr Val Arg 
            900                 905                 910         


Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val Thr Glu 
        915                 920                 925             


Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro Pro Thr 
    930                 935                 940                 


Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu Ser Val 
945                 950                 955                 960 


Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val Thr Trp 
                965                 970                 975     


Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln Ile Thr 
            980                 985                 990         


Phe Gln Ser Gly Ile Ala Arg Leu  Met Ile Arg Glu Ala  Phe Ala Glu 
        995                 1000                 1005             


Asp Ser  Gly Arg Phe Thr Cys  Ser Ala Val Asn Glu  Ala Gly Thr 
    1010                 1015                 1020             


Val Ser  Thr Ser Cys Tyr Leu  Ala Val Gln Val Ser  Glu Glu Phe 
    1025                 1030                 1035             


Glu Lys  Glu Thr Thr Ala Val  Thr Glu Lys Phe Thr  Thr Glu Glu 
    1040                 1045                 1050             


Lys Arg  Phe Val Glu Ser Arg  Asp Val Val Met Thr  Asp Thr Ser 
    1055                 1060                 1065             


Leu Thr  Glu Glu Gln Ala Gly  Pro Gly Glu Pro Ala  Ala Pro Tyr 
    1070                 1075                 1080             


Phe Ile  Thr Lys Pro Val Val  Gln Lys Leu Val Glu  Gly Gly Ser 
    1085                 1090                 1095             


Val Val  Phe Gly Cys Gln Val  Gly Gly Asn Pro Lys  Pro His Val 
    1100                 1105                 1110             


Tyr Trp  Lys Lys Ser Gly Val  Pro Leu Thr Thr Gly  Tyr Arg Tyr 
    1115                 1120                 1125             


Lys Val  Ser Tyr Asn Lys Gln  Thr Gly Glu Cys Lys  Leu Val Ile 
    1130                 1135                 1140             


Ser Met  Thr Phe Ala Asp Asp  Ala Gly Glu Tyr Thr  Ile Val Val 
    1145                 1150                 1155             


Arg Asn  Lys His Gly Glu Thr  Ser Ala Ser Ala Ser  Leu Leu Glu 
    1160                 1165                 1170             


Glu Ala  Asp Tyr Glu Leu Leu  Met Lys Ser Gln Gln  Glu Met Leu 
    1175                 1180                 1185             


Tyr Gln  Thr Gln Val Thr Ala  Phe Val Gln Glu Pro  Lys Val Gly 
    1190                 1195                 1200             


Glu Thr  Ala Pro Gly Phe Val  Tyr Ser Glu Tyr Glu  Lys Glu Tyr 
    1205                 1210                 1215             


Glu Lys  Glu Gln Ala Leu Ile  Arg Lys Lys Met Ala  Lys Asp Thr 
    1220                 1225                 1230             


Val Val  Val Arg Thr Tyr Val  Glu Asp Gln Glu Phe  His Ile Ser 
    1235                 1240                 1245             


Ser Phe  Glu Glu Arg Leu Ile  Lys Glu Ile Glu Tyr  Arg Ile Ile 
    1250                 1255                 1260             


Lys Thr  Thr Leu Glu Glu Leu  Leu Glu Glu Asp Gly  Glu Glu Lys 
    1265                 1270                 1275             


Met Ala  Val Asp Ile Ser Glu  Ser Glu Ala Val Glu  Ser Gly Phe 
    1280                 1285                 1290             


Asp Leu  Arg Ile Lys Asn Tyr  Arg Ile Leu Glu Gly  Met Gly Val 
    1295                 1300                 1305             


Thr Phe  His Cys Lys Met Ser  Gly Tyr Pro Leu Pro  Lys Ile Ala 
    1310                 1315                 1320             


Trp Tyr  Lys Asp Gly Lys Arg  Ile Lys His Gly Glu  Arg Tyr Gln 
    1325                 1330                 1335             


Met Asp  Phe Leu Gln Asp Gly  Arg Ala Ser Leu Arg  Ile Pro Val 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Glu Gly  Ile Tyr Thr Ala Phe  Ala Ser Asn 
    1355                 1360                 1365             


Ile Lys  Gly Asn Ala Ile Cys  Ser Gly Lys Leu Tyr  Val Glu Pro 
    1370                 1375                 1380             


Ala Ala  Pro Leu Gly Ala Pro  Thr Tyr Ile Pro Thr  Leu Glu Pro 
    1385                 1390                 1395             


Val Ser  Arg Ile Arg Ser Leu  Ser Pro Arg Ser Val  Ser Arg Ser 
    1400                 1405                 1410             


Pro Ile  Arg Met Ser Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser 
    1415                 1420                 1425             


Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser Pro Gly  Arg Arg Leu 
    1430                 1435                 1440             


Glu Glu  Thr Asp Glu Ser Gln  Leu Glu Arg Leu Tyr  Lys Pro Val 
    1445                 1450                 1455             


Phe Val  Leu Lys Pro Val Ser  Phe Lys Cys Leu Glu  Gly Gln Thr 
    1460                 1465                 1470             


Ala Arg  Phe Asp Leu Lys Val  Val Gly Arg Pro Met  Pro Glu Thr 
    1475                 1480                 1485             


Phe Trp  Phe His Asp Gly Gln  Gln Ile Val Asn Asp  Tyr Thr His 
    1490                 1495                 1500             


Lys Val  Val Ile Lys Glu Asp  Gly Thr Gln Ser Leu  Ile Ile Val 
    1505                 1510                 1515             


Pro Ala  Thr Pro Ser Asp Ser  Gly Glu Trp Thr Val  Val Ala Gln 
    1520                 1525                 1530             


Asn Arg  Ala Gly Arg Ser Ser  Ile Ser Val Ile Leu  Thr Val Glu 
    1535                 1540                 1545             


Ala Val  Glu His Gln Val Lys  Pro Met Phe Val Glu  Lys Leu Lys 
    1550                 1555                 1560             


Asn Val  Asn Ile Lys Glu Gly  Ser Gln Leu Glu Met  Lys Val Arg 
    1565                 1570                 1575             


Ala Thr  Gly Asn Pro Asn Pro  Asp Ile Val Trp Leu  Lys Asn Ser 
    1580                 1585                 1590             


Asp Ile  Ile Val Pro His Lys  Tyr Pro Lys Ile Arg  Ile Glu Gly 
    1595                 1600                 1605             


Thr Lys  Gly Glu Ala Ala Leu  Lys Ile Asp Ser Thr  Val Ser Gln 
    1610                 1615                 1620             


Asp Ser  Ala Trp Tyr Thr Ala  Thr Ala Ile Asn Lys  Ala Gly Arg 
    1625                 1630                 1635             


Asp Thr  Thr Arg Cys Lys Val  Asn Val Glu Val Glu  Phe Ala Glu 
    1640                 1645                 1650             


Pro Glu  Pro Glu Arg Lys Leu  Ile Ile Pro Arg Gly  Thr Tyr Arg 
    1655                 1660                 1665             


Ala Lys  Glu Ile Ala Ala Pro  Glu Leu Glu Pro Leu  His Leu Arg 
    1670                 1675                 1680             


Tyr Gly  Gln Glu Gln Trp Glu  Glu Gly Asp Leu Tyr  Asp Lys Glu 
    1685                 1690                 1695             


Lys Gln  Gln Lys Pro Phe Phe  Lys Lys Lys Leu Thr  Ser Leu Arg 
    1700                 1705                 1710             


Leu Lys  Arg Phe Gly Pro Ala  His Phe Glu Cys Arg  Leu Thr Pro 
    1715                 1720                 1725             


Ile Gly  Asp Pro Thr Met Val  Val Glu Trp Leu His  Asp Gly Lys 
    1730                 1735                 1740             


Pro Leu  Glu Ala Ala Asn Arg  Leu Arg Met Ile Asn  Glu Phe Gly 
    1745                 1750                 1755             


Tyr Cys  Ser Leu Asp Tyr Gly  Val Ala Tyr Ser Arg  Asp Ser Gly 
    1760                 1765                 1770             


Ile Ile  Thr Cys Arg Ala Thr  Asn Lys Tyr Gly Thr  Asp His Thr 
    1775                 1780                 1785             


Ser Ala  Thr Leu Ile Val Lys  Asp Glu Lys Ser Leu  Val Glu Glu 
    1790                 1795                 1800             


Ser Gln  Leu Pro Glu Gly Arg  Lys Gly Leu Gln Arg  Ile Glu Glu 
    1805                 1810                 1815             


Leu Glu  Arg Met Ala His Glu  Gly Ala Leu Thr Gly  Val Thr Thr 
    1820                 1825                 1830             


Asp Gln  Lys Glu Lys Gln Lys  Pro Asp Ile Val Leu  Tyr Pro Glu 
    1835                 1840                 1845             


Pro Val  Arg Val Leu Glu Gly  Glu Thr Ala Arg Phe  Arg Cys Arg 
    1850                 1855                 1860             


Val Thr  Gly Tyr Pro Gln Pro  Lys Val Asn Trp Tyr  Leu Asn Gly 
    1865                 1870                 1875             


Gln Leu  Ile Arg Lys Ser Lys  Arg Phe Arg Val Arg  Tyr Asp Gly 
    1880                 1885                 1890             


Ile His  Tyr Leu Asp Ile Val  Asp Cys Lys Ser Tyr  Asp Thr Gly 
    1895                 1900                 1905             


Glu Val  Lys Val Thr Ala Glu  Asn Pro Glu Gly Val  Ile Glu His 
    1910                 1915                 1920             


Lys Val  Lys Leu Glu Ile Gln  Gln Arg Glu Asp Phe  Arg Ser Val 
    1925                 1930                 1935             


Leu Arg  Arg Ala Pro Glu Pro  Arg Pro Glu Phe His  Val His Glu 
    1940                 1945                 1950             


Pro Gly  Lys Leu Gln Phe Glu  Val Gln Lys Val Asp  Arg Pro Val 
    1955                 1960                 1965             


Asp Thr  Thr Glu Thr Lys Glu  Val Val Lys Leu Lys  Arg Ala Glu 
    1970                 1975                 1980             


Arg Ile  Thr His Glu Lys Val  Pro Glu Glu Ser Glu  Glu Leu Arg 
    1985                 1990                 1995             


Ser Lys  Phe Lys Arg Arg Thr  Glu Glu Gly Tyr Tyr  Glu Ala Ile 
    2000                 2005                 2010             


Thr Ala  Val Glu Leu Lys Ser  Arg Lys Lys Asp Glu  Ser Tyr Glu 
    2015                 2020                 2025             


Glu Leu  Leu Arg Lys Thr Lys  Asp Glu Leu Leu His  Trp Thr Lys 
    2030                 2035                 2040             


Glu Leu  Thr Glu Glu Glu Lys  Lys Ala Leu Ala Glu  Glu Gly Lys 
    2045                 2050                 2055             


Ile Thr  Ile Pro Thr Phe Lys  Pro Asp Lys Ile Glu  Leu Ser Pro 
    2060                 2065                 2070             


Ser Met  Glu Ala Pro Lys Ile  Phe Glu Arg Ile Gln  Ser Gln Thr 
    2075                 2080                 2085             


Val Gly  Gln Gly Ser Asp Ala  His Phe Arg Val Arg  Val Val Gly 
    2090                 2095                 2100             


Lys Pro  Asp Pro Glu Cys Glu  Trp Tyr Lys Asn Gly  Val Lys Ile 
    2105                 2110                 2115             


Glu Arg  Ser Asp Arg Ile Tyr  Trp Tyr Trp Pro Glu  Asp Asn Val 
    2120                 2125                 2130             


Cys Glu  Leu Val Ile Arg Asp  Val Thr Ala Glu Asp  Ser Ala Ser 
    2135                 2140                 2145             


Ile Met  Val Lys Ala Ile Asn  Ile Ala Gly Glu Thr  Ser Ser His 
    2150                 2155                 2160             


Ala Phe  Leu Leu Val Gln Ala  Lys Gln Leu Ile Thr  Phe Thr Gln 
    2165                 2170                 2175             


Glu Leu  Gln Asp Val Val Ala  Lys Glu Lys Asp Thr  Met Ala Thr 
    2180                 2185                 2190             


Phe Glu  Cys Glu Thr Ser Glu  Pro Phe Val Lys Val  Lys Trp Tyr 
    2195                 2200                 2205             


Lys Asp  Gly Met Glu Val His  Glu Gly Asp Lys Tyr  Arg Met His 
    2210                 2215                 2220             


Ser Asp  Arg Lys Val His Phe  Leu Ser Ile Leu Thr  Ile Asp Thr 
    2225                 2230                 2235             


Ser Asp  Ala Glu Asp Tyr Ser  Cys Val Leu Val Glu  Asp Glu Asn 
    2240                 2245                 2250             


Val Lys  Thr Thr Ala Lys Leu  Ile Val Glu Gly Ala  Val Val Glu 
    2255                 2260                 2265             


Phe Val  Lys Glu Leu Gln Asp  Ile Glu Val Pro Glu  Ser Tyr Ser 
    2270                 2275                 2280             


Gly Glu  Leu Glu Cys Ile Val  Ser Pro Glu Asn Ile  Glu Gly Lys 
    2285                 2290                 2295             


Trp Tyr  His Asn Asp Val Glu  Leu Lys Ser Asn Gly  Lys Tyr Thr 
    2300                 2305                 2310             


Ile Thr  Ser Arg Arg Gly Arg  Gln Asn Leu Thr Val  Lys Asp Val 
    2315                 2320                 2325             


Thr Lys  Glu Asp Gln Gly Glu  Tyr Ser Phe Val Ile  Asp Gly Lys 
    2330                 2335                 2340             


Lys Thr  Thr Cys Lys Leu Lys  Met Lys Pro Arg Pro  Ile Ala Ile 
    2345                 2350                 2355             


Leu Gln  Gly Leu Ser Asp Gln  Lys Val Cys Glu Gly  Asp Ile Val 
    2360                 2365                 2370             


Gln Leu  Glu Val Lys Val Ser  Leu Glu Ser Val Glu  Gly Val Trp 
    2375                 2380                 2385             


Met Lys  Asp Gly Gln Glu Val  Gln Pro Ser Asp Arg  Val His Ile 
    2390                 2395                 2400             


Val Ile  Asp Lys Gln Ser His  Met Leu Leu Ile Glu  Asp Met Thr 
    2405                 2410                 2415             


Lys Glu  Asp Ala Gly Asn Tyr  Ser Phe Thr Ile Pro  Ala Leu Gly 
    2420                 2425                 2430             


Leu Ser  Thr Ser Gly Arg Val  Ser Val Tyr Ser Val  Asp Val Ile 
    2435                 2440                 2445             


Thr Pro  Leu Lys Asp Val Asn  Val Ile Glu Gly Thr  Lys Ala Val 
    2450                 2455                 2460             


Leu Glu  Cys Lys Val Ser Val  Pro Asp Val Thr Ser  Val Lys Trp 
    2465                 2470                 2475             


Tyr Leu  Asn Asp Glu Gln Ile  Lys Pro Asp Asp Arg  Val Gln Ala 
    2480                 2485                 2490             


Ile Val  Lys Gly Thr Lys Gln  Arg Leu Val Ile Asn  Arg Thr His 
    2495                 2500                 2505             


Ala Ser  Asp Glu Gly Pro Tyr  Lys Leu Ile Val Gly  Arg Val Glu 
    2510                 2515                 2520             


Thr Asn  Cys Asn Leu Ser Val  Glu Lys Ile Lys Ile  Ile Arg Gly 
    2525                 2530                 2535             


Leu Arg  Asp Leu Thr Cys Thr  Glu Thr Gln Asn Val  Val Phe Glu 
    2540                 2545                 2550             


Val Glu  Leu Ser His Ser Gly  Ile Asp Val Leu Trp  Asn Phe Lys 
    2555                 2560                 2565             


Asp Lys  Glu Ile Lys Pro Ser  Ser Lys Tyr Lys Ile  Glu Ala His 
    2570                 2575                 2580             


Gly Lys  Ile Tyr Lys Leu Thr  Val Leu Asn Met Met  Lys Asp Asp 
    2585                 2590                 2595             


Glu Gly  Lys Tyr Thr Phe Tyr  Ala Gly Glu Asn Ile  Thr Ser Gly 
    2600                 2605                 2610             


Lys Leu  Thr Val Ala Gly Gly  Ala Ile Ser Lys Pro  Leu Thr Asp 
    2615                 2620                 2625             


Gln Thr  Val Ala Glu Ser Gln  Glu Ala Val Phe Glu  Cys Glu Val 
    2630                 2635                 2640             


Ala Asn  Pro Asp Ser Lys Gly  Glu Trp Leu Arg Asp  Gly Lys His 
    2645                 2650                 2655             


Leu Pro  Leu Thr Asn Asn Ile  Arg Ser Glu Ser Asp  Gly His Lys 
    2660                 2665                 2670             


Arg Arg  Leu Ile Ile Ala Ala  Thr Lys Leu Asp Asp  Ile Gly Glu 
    2675                 2680                 2685             


Tyr Thr  Tyr Lys Val Ala Thr  Ser Lys Thr Ser Ala  Lys Leu Lys 
    2690                 2695                 2700             


Val Glu  Ala Val Lys Ile Lys  Lys Thr Leu Lys Asn  Leu Thr Val 
    2705                 2710                 2715             


Thr Glu  Thr Gln Asp Ala Val  Phe Thr Val Glu Leu  Thr His Pro 
    2720                 2725                 2730             


Asn Val  Lys Gly Val Gln Trp  Ile Lys Asn Gly Val  Val Leu Glu 
    2735                 2740                 2745             


Ser Asn  Glu Lys Tyr Ala Ile  Ser Val Lys Gly Thr  Ile Tyr Ser 
    2750                 2755                 2760             


Leu Arg  Ile Lys Asn Cys Ala  Ile Val Asp Glu Ser  Val Tyr Gly 
    2765                 2770                 2775             


Phe Arg  Leu Gly Arg Leu Gly  Ala Ser Ala Arg Leu  His Val Glu 
    2780                 2785                 2790             


Thr Val  Lys Ile Ile Lys Lys  Pro Lys Asp Val Thr  Ala Leu Glu 
    2795                 2800                 2805             


Asn Ala  Thr Val Ala Phe Glu  Val Ser Val Ser His  Asp Thr Val 
    2810                 2815                 2820             


Pro Val  Lys Trp Phe His Lys  Asn Val Glu Ile Lys  Pro Ser Asp 
    2825                 2830                 2835             


Lys His  Arg Leu Val Ser Glu  Arg Lys Val His Lys  Leu Met Leu 
    2840                 2845                 2850             


Gln Asn  Ile Ser Pro Ser Asp  Ala Gly Glu Tyr Thr  Ala Val Val 
    2855                 2860                 2865             


Gly Gln  Leu Glu Cys Lys Ala  Lys Leu Phe Val Glu  Thr Leu His 
    2870                 2875                 2880             


Ile Thr  Lys Thr Met Lys Asn  Ile Glu Val Pro Glu  Thr Lys Thr 
    2885                 2890                 2895             


Ala Ser  Phe Glu Cys Glu Val  Ser His Phe Asn Val  Pro Ser Met 
    2900                 2905                 2910             


Trp Leu  Lys Asn Gly Val Glu  Ile Glu Met Ser Glu  Lys Phe Lys 
    2915                 2920                 2925             


Ile Val  Val Gln Gly Lys Leu  His Gln Leu Ile Ile  Met Asn Thr 
    2930                 2935                 2940             


Ser Thr  Glu Asp Ser Ala Glu  Tyr Thr Phe Val Cys  Gly Asn Asp 
    2945                 2950                 2955             


Gln Val  Ser Ala Thr Leu Thr  Val Thr Pro Ile Met  Ile Thr Ser 
    2960                 2965                 2970             


Met Leu  Lys Asp Ile Asn Ala  Glu Glu Lys Asp Thr  Ile Thr Phe 
    2975                 2980                 2985             


Glu Val  Thr Val Asn Tyr Glu  Gly Ile Ser Tyr Lys  Trp Leu Lys 
    2990                 2995                 3000             


Asn Gly  Val Glu Ile Lys Ser  Thr Asp Lys Cys Gln  Met Arg Thr 
    3005                 3010                 3015             


Lys Lys  Leu Thr His Ser Leu  Asn Ile Arg Asn Val  His Phe Gly 
    3020                 3025                 3030             


Asp Ala  Ala Asp Tyr Thr Phe  Val Ala Gly Lys Ala  Thr Ser Thr 
    3035                 3040                 3045             


Ala Thr  Leu Tyr Val Glu Ala  Arg His Ile Glu Phe  Arg Lys His 
    3050                 3055                 3060             


Ile Lys  Asp Ile Lys Val Leu  Glu Lys Lys Arg Ala  Met Phe Glu 
    3065                 3070                 3075             


Cys Glu  Val Ser Glu Pro Asp  Ile Thr Val Gln Trp  Met Lys Asp 
    3080                 3085                 3090             


Asp Gln  Glu Leu Gln Ile Thr  Asp Arg Ile Lys Ile  Gln Lys Glu 
    3095                 3100                 3105             


Lys Tyr  Val His Arg Leu Leu  Ile Pro Ser Thr Arg  Met Ser Asp 
    3110                 3115                 3120             


Ala Gly  Lys Tyr Thr Val Val  Ala Gly Gly Asn Val  Ser Thr Ala 
    3125                 3130                 3135             


Lys Leu  Phe Val Glu Gly Arg  Asp Val Arg Ile Arg  Ser Ile Lys 
    3140                 3145                 3150             


Lys Glu  Val Gln Val Ile Glu  Lys Gln Arg Ala Val  Val Glu Phe 
    3155                 3160                 3165             


Glu Val  Asn Glu Asp Asp Val  Asp Ala His Trp Tyr  Lys Asp Gly 
    3170                 3175                 3180             


Ile Glu  Ile Asn Phe Gln Val  Gln Glu Arg His Lys  Tyr Val Val 
    3185                 3190                 3195             


Glu Arg  Arg Ile His Arg Met  Phe Ile Ser Glu Thr  Arg Gln Ser 
    3200                 3205                 3210             


Asp Ala  Gly Glu Tyr Thr Phe  Val Ala Gly Arg Asn  Arg Ser Ser 
    3215                 3220                 3225             


Val Thr  Leu Tyr Val Asn Ala  Pro Glu Pro Pro Gln  Val Leu Gln 
    3230                 3235                 3240             


Glu Leu  Gln Pro Val Thr Val  Gln Ser Gly Lys Pro  Ala Arg Phe 
    3245                 3250                 3255             


Cys Ala  Val Ile Ser Gly Arg  Pro Gln Pro Lys Ile  Ser Trp Tyr 
    3260                 3265                 3270             


Lys Glu  Glu Gln Leu Leu Ser  Thr Gly Phe Lys Cys  Lys Phe Leu 
    3275                 3280                 3285             


His Asp  Gly Gln Glu Tyr Thr  Leu Leu Leu Ile Glu  Ala Phe Pro 
    3290                 3295                 3300             


Glu Asp  Ala Ala Val Tyr Thr  Cys Glu Ala Lys Asn  Asp Tyr Gly 
    3305                 3310                 3315             


Val Ala  Thr Thr Ser Ala Ser  Leu Ser Val Glu Val  Pro Glu Val 
    3320                 3325                 3330             


Val Ser  Pro Asp Gln Glu Met  Pro Val Tyr Pro Pro  Ala Ile Ile 
    3335                 3340                 3345             


Thr Pro  Leu Gln Asp Thr Val  Thr Ser Glu Gly Gln  Pro Ala Arg 
    3350                 3355                 3360             


Phe Gln  Cys Arg Val Ser Gly  Thr Asp Leu Lys Val  Ser Trp Tyr 
    3365                 3370                 3375             


Ser Lys  Asp Lys Lys Ile Lys  Pro Ser Arg Phe Phe  Arg Met Thr 
    3380                 3385                 3390             


Gln Phe  Glu Asp Thr Tyr Gln  Leu Glu Ile Ala Glu  Ala Tyr Pro 
    3395                 3400                 3405             


Glu Asp  Glu Gly Thr Tyr Thr  Phe Val Ala Ser Asn  Ala Val Gly 
    3410                 3415                 3420             


Gln Val  Ser Ser Thr Ala Asn  Leu Ser Leu Glu Ala  Pro Glu Ser 
    3425                 3430                 3435             


Ile Leu  His Glu Arg Ile Glu  Gln Glu Ile Glu Met  Glu Met Lys 
    3440                 3445                 3450             


Glu Phe  Ser Ser Ser Phe Leu  Ser Ala Glu Glu Glu  Gly Leu His 
    3455                 3460                 3465             


Ser Ala  Glu Leu Gln Leu Ser  Lys Ile Asn Glu Thr  Leu Glu Leu 
    3470                 3475                 3480             


Leu Ser  Glu Ser Pro Val Tyr  Ser Thr Lys Phe Asp  Ser Glu Lys 
    3485                 3490                 3495             


Glu Gly  Thr Gly Pro Ile Phe  Ile Lys Glu Val Ser  Asn Ala Asp 
    3500                 3505                 3510             


Ile Ser  Met Gly Asp Val Ala  Thr Leu Ser Val Thr  Val Ile Gly 
    3515                 3520                 3525             


Ile Pro  Lys Pro Lys Ile Gln  Trp Phe Phe Asn Gly  Val Leu Leu 
    3530                 3535                 3540             


Thr Pro  Ser Ala Asp Tyr Lys  Phe Val Phe Asp Gly  Asp Asp His 
    3545                 3550                 3555             


Ser Leu  Ile Ile Leu Phe Thr  Lys Leu Glu Asp Glu  Gly Glu Tyr 
    3560                 3565                 3570             


Thr Cys  Met Ala Ser Asn Asp  Tyr Gly Lys Thr Ile  Cys Ser Ala 
    3575                 3580                 3585             


Tyr Leu  Lys Ile Asn Ser Lys  Gly Glu Gly His Lys  Asp Thr Glu 
    3590                 3595                 3600             


Thr Glu  Ser Ala Val Ala Lys  Ser Leu Glu Lys Leu  Gly Gly Pro 
    3605                 3610                 3615             


Cys Pro  Pro His Phe Leu Lys  Glu Leu Lys Pro Ile  Arg Cys Ala 
    3620                 3625                 3630             


Gln Gly  Leu Pro Ala Ile Phe  Glu Tyr Thr Val Val  Gly Glu Pro 
    3635                 3640                 3645             


Ala Pro  Thr Val Thr Trp Phe  Lys Glu Asn Lys Gln  Leu Cys Thr 
    3650                 3655                 3660             


Ser Val  Tyr Tyr Thr Ile Ile  His Asn Pro Asn Gly  Ser Gly Thr 
    3665                 3670                 3675             


Phe Ile  Val Asn Asp Pro Gln  Arg Glu Asp Ser Gly  Leu Tyr Ile 
    3680                 3685                 3690             


Cys Lys  Ala Glu Asn Met Leu  Gly Glu Ser Thr Cys  Ala Ala Glu 
    3695                 3700                 3705             


Leu Leu  Val Leu Leu Glu Asp  Thr Asp Met Thr Asp  Thr Pro Cys 
    3710                 3715                 3720             


Lys Ala  Lys Ser Thr Pro Glu  Ala Pro Glu Asp Phe  Pro Gln Thr 
    3725                 3730                 3735             


Pro Leu  Lys Gly Pro Ala Val  Glu Ala Leu Asp Ser  Glu Gln Glu 
    3740                 3745                 3750             


Ile Ala  Thr Phe Val Lys Asp  Thr Ile Leu Lys Ala  Ala Leu Ile 
    3755                 3760                 3765             


Thr Glu  Glu Asn Gln Gln Leu  Ser Tyr Glu His Ile  Ala Lys Ala 
    3770                 3775                 3780             


Asn Glu  Leu Ser Ser Gln Leu  Pro Leu Gly Ala Gln  Glu Leu Gln 
    3785                 3790                 3795             


Ser Ile  Leu Glu Gln Asp Lys  Leu Thr Pro Glu Ser  Thr Arg Glu 
    3800                 3805                 3810             


Phe Leu  Cys Ile Asn Gly Ser  Ile His Phe Gln Pro  Leu Lys Glu 
    3815                 3820                 3825             


Pro Ser  Pro Asn Leu Gln Leu  Gln Ile Val Gln Ser  Gln Lys Thr 
    3830                 3835                 3840             


Phe Ser  Lys Glu Gly Ile Leu  Met Pro Glu Glu Pro  Glu Thr Gln 
    3845                 3850                 3855             


Ala Val  Leu Ser Asp Thr Glu  Lys Ile Phe Pro Ser  Ala Met Ser 
    3860                 3865                 3870             


Ile Glu  Gln Ile Asn Ser Leu  Thr Val Glu Pro Leu  Lys Thr Leu 
    3875                 3880                 3885             


Leu Ala  Glu Pro Glu Gly Asn  Tyr Pro Gln Ser Ser  Ile Glu Pro 
    3890                 3895                 3900             


Pro Met  His Ser Tyr Leu Thr  Ser Val Ala Glu Glu  Val Leu Ser 
    3905                 3910                 3915             


Pro Lys  Glu Lys Thr Val Ser  Asp Thr Asn Arg Glu  Gln Arg Val 
    3920                 3925                 3930             


Thr Leu  Gln Lys Gln Glu Ala  Gln Ser Ala Leu Ile  Leu Ser Gln 
    3935                 3940                 3945             


Ser Leu  Ala Glu Gly His Val  Glu Ser Leu Gln Ser  Pro Asp Val 
    3950                 3955                 3960             


Met Ile  Ser Gln Val Asn Tyr  Glu Pro Leu Val Pro  Ser Glu His 
    3965                 3970                 3975             


Ser Cys  Thr Glu Gly Gly Lys  Ile Leu Ile Glu Ser  Ala Asn Pro 
    3980                 3985                 3990             


Leu Glu  Asn Ala Gly Gln Asp  Ser Ala Val Arg Ile  Glu Glu Gly 
    3995                 4000                 4005             


Lys Ser  Leu Arg Phe Pro Leu  Ala Leu Glu Glu Lys  Gln Val Leu 
    4010                 4015                 4020             


Leu Lys  Glu Glu His Ser Asp  Asn Val Val Met Pro  Pro Asp Gln 
    4025                 4030                 4035             


Ile Ile  Glu Ser Lys Arg Glu  Pro Val Ala Ile Lys  Lys Val Gln 
    4040                 4045                 4050             


Glu Val  Gln Gly Arg Asp Leu  Leu Ser Lys Glu Ser  Leu Leu Ser 
    4055                 4060                 4065             


Gly Ile  Pro Glu Glu Gln Arg  Leu Asn Leu Lys Ile  Gln Ile Cys 
    4070                 4075                 4080             


Arg Ala  Leu Gln Ala Ala Val  Ala Ser Glu Gln Pro  Gly Leu Phe 
    4085                 4090                 4095             


Ser Glu  Trp Leu Arg Asn Ile  Glu Lys Val Glu Val  Glu Ala Val 
    4100                 4105                 4110             


Asn Ile  Thr Gln Glu Pro Arg  His Ile Met Cys Met  Tyr Leu Val 
    4115                 4120                 4125             


Thr Ser  Ala Lys Ser Val Thr  Glu Glu Val Thr Ile  Ile Ile Glu 
    4130                 4135                 4140             


Asp Val  Asp Pro Gln Met Ala  Asn Leu Lys Met Glu  Leu Arg Asp 
    4145                 4150                 4155             


Ala Leu  Cys Ala Ile Ile Tyr  Glu Glu Ile Asp Ile  Leu Thr Ala 
    4160                 4165                 4170             


Glu Gly  Pro Arg Ile Gln Gln  Gly Ala Lys Thr Ser  Leu Gln Glu 
    4175                 4180                 4185             


Glu Met  Asp Ser Phe Ser Gly  Ser Gln Lys Val Glu  Pro Ile Thr 
    4190                 4195                 4200             


Glu Pro  Glu Val Glu Ser Lys  Tyr Leu Ile Ser Pro  Glu Glu Val 
    4205                 4210                 4215             


Ser Tyr  Phe Asn Val Gln Ser  Arg Val Lys Tyr Leu  Asp Ala Thr 
    4220                 4225                 4230             


Pro Val  Thr Lys Gly Val Ala  Ser Ala Val Val Ser  Asp Glu Lys 
    4235                 4240                 4245             


Gln Asp  Glu Ser Leu Lys Pro  Ser Glu Glu Lys Glu  Glu Ser Ser 
    4250                 4255                 4260             


Ser Glu  Ser Gly Thr Glu Glu  Val Ala Thr Val Lys  Ile Gln Glu 
    4265                 4270                 4275             


Ala Glu  Gly Gly Phe Ile Lys  Glu Asp Gly Pro Met  Ile His Thr 
    4280                 4285                 4290             


Pro Leu  Val Asp Thr Val Ser  Glu Glu Gly Asp Ile  Val His Leu 
    4295                 4300                 4305             


Thr Thr  Ser Ile Thr Asn Ala  Lys Glu Val Asn Trp  Tyr Phe Glu 
    4310                 4315                 4320             


Asn Lys  Leu Val Pro Ser Asp  Glu Lys Phe Lys Cys  Leu Gln Asp 
    4325                 4330                 4335             


Gln Asn  Thr Tyr Thr Leu Val  Ile Asp Lys Val Asn  Thr Glu Asp 
    4340                 4345                 4350             


His Gln  Gly Glu Tyr Val Cys  Glu Ala Leu Asn Asp  Ser Gly Lys 
    4355                 4360                 4365             


Thr Ala  Thr Ser Ala Lys Leu  Thr Val Val Lys Arg  Ala Ala Pro 
    4370                 4375                 4380             


Val Ile  Lys Arg Lys Ile Glu  Pro Leu Glu Val Ala  Leu Gly His 
    4385                 4390                 4395             


Leu Ala  Lys Phe Thr Cys Glu  Ile Gln Ser Ala Pro  Asn Val Arg 
    4400                 4405                 4410             


Phe Gln  Trp Phe Lys Ala Gly  Arg Glu Ile Tyr Glu  Ser Asp Lys 
    4415                 4420                 4425             


Cys Ser  Ile Arg Ser Ser Lys  Tyr Ile Ser Ser Leu  Glu Ile Leu 
    4430                 4435                 4440             


Arg Thr  Gln Val Val Asp Cys  Gly Glu Tyr Thr Cys  Lys Ala Ser 
    4445                 4450                 4455             


Asn Glu  Tyr Gly Ser Val Ser  Cys Thr Ala Thr Leu  Thr Val Thr 
    4460                 4465                 4470             


Glu Ala  Tyr Pro Pro Thr Phe  Leu Ser Arg Pro Lys  Ser Leu Thr 
    4475                 4480                 4485             


Thr Phe  Val Gly Lys Ala Ala  Lys Phe Ile Cys Thr  Val Thr Gly 
    4490                 4495                 4500             


Thr Pro  Val Ile Glu Thr Ile  Trp Gln Lys Asp Gly  Ala Ala Leu 
    4505                 4510                 4515             


Ser Pro  Ser Pro Asn Trp Lys  Ile Ser Asp Ala Glu  Asn Lys His 
    4520                 4525                 4530             


Ile Leu  Glu Leu Ser Asn Leu  Thr Ile Gln Asp Arg  Gly Val Tyr 
    4535                 4540                 4545             


Ser Cys  Lys Ala Ser Asn Lys  Phe Gly Ala Asp Ile  Cys Gln Ala 
    4550                 4555                 4560             


Glu Leu  Ile Ile Ile Asp Lys  Pro His Phe Ile Lys  Glu Leu Glu 
    4565                 4570                 4575             


Pro Val  Gln Ser Ala Ile Asn  Lys Lys Val His Leu  Glu Cys Gln 
    4580                 4585                 4590             


Val Asp  Glu Asp Arg Lys Val  Thr Val Thr Trp Ser  Lys Asp Gly 
    4595                 4600                 4605             


Gln Lys  Leu Pro Pro Gly Lys  Asp Tyr Lys Ile Cys  Phe Glu Asp 
    4610                 4615                 4620             


Lys Ile  Ala Thr Leu Glu Ile  Pro Leu Ala Lys Leu  Lys Asp Ser 
    4625                 4630                 4635             


Gly Thr  Tyr Val Cys Thr Ala  Ser Asn Glu Ala Gly  Ser Ser Ser 
    4640                 4645                 4650             


Cys Ser  Ala Thr Val Thr Val  Arg Glu Pro Pro Ser  Phe Val Lys 
    4655                 4660                 4665             


Lys Val  Asp Pro Ser Tyr Leu  Met Leu Pro Gly Glu  Ser Ala Arg 
    4670                 4675                 4680             


Leu His  Cys Lys Leu Lys Gly  Ser Pro Val Ile Gln  Val Thr Trp 
    4685                 4690                 4695             


Phe Lys  Asn Asn Lys Glu Leu  Ser Glu Ser Asn Thr  Val Arg Met 
    4700                 4705                 4710             


Tyr Phe  Val Asn Ser Glu Ala  Ile Leu Asp Ile Thr  Asp Val Lys 
    4715                 4720                 4725             


Val Glu  Asp Ser Gly Ser Tyr  Ser Cys Glu Ala Val  Asn Asp Val 
    4730                 4735                 4740             


Gly Ser  Asp Ser Cys Ser Thr  Glu Ile Val Ile Lys  Glu Pro Pro 
    4745                 4750                 4755             


Ser Phe  Ile Lys Thr Leu Glu  Pro Ala Asp Ile Val  Arg Gly Thr 
    4760                 4765                 4770             


Asn Ala  Leu Leu Gln Cys Glu  Val Ser Gly Thr Gly  Pro Phe Glu 
    4775                 4780                 4785             


Ile Ser  Trp Phe Lys Asp Lys  Lys Gln Ile Arg Ser  Ser Lys Lys 
    4790                 4795                 4800             


Tyr Arg  Leu Phe Ser Gln Lys  Ser Leu Val Cys Leu  Glu Ile Phe 
    4805                 4810                 4815             


Ser Phe  Asn Ser Ala Asp Val  Gly Glu Tyr Glu Cys  Val Val Ala 
    4820                 4825                 4830             


Asn Glu  Val Gly Lys Cys Gly  Cys Met Ala Thr His  Leu Leu Lys 
    4835                 4840                 4845             


Glu Pro  Pro Thr Phe Val Lys  Lys Val Asp Asp Leu  Ile Ala Leu 
    4850                 4855                 4860             


Gly Gly  Gln Thr Val Thr Leu  Gln Ala Ala Val Arg  Gly Ser Glu 
    4865                 4870                 4875             


Pro Ile  Ser Val Thr Trp Met  Lys Gly Gln Glu Val  Ile Arg Glu 
    4880                 4885                 4890             


Asp Gly  Lys Ile Lys Met Ser  Phe Ser Asn Gly Val  Ala Val Leu 
    4895                 4900                 4905             


Ile Ile  Pro Asp Val Gln Ile  Ser Phe Gly Gly Lys  Tyr Thr Cys 
    4910                 4915                 4920             


Leu Ala  Glu Asn Glu Ala Gly  Ser Gln Thr Ser Val  Gly Glu Leu 
    4925                 4930                 4935             


Ile Val  Lys Glu Pro Ala Lys  Ile Ile Glu Arg Ala  Glu Leu Ile 
    4940                 4945                 4950             


Gln Val  Thr Ala Gly Asp Pro  Ala Thr Leu Glu Tyr  Thr Val Ala 
    4955                 4960                 4965             


Gly Thr  Pro Glu Leu Lys Pro  Lys Trp Tyr Lys Asp  Gly Arg Pro 
    4970                 4975                 4980             


Leu Val  Ala Ser Lys Lys Tyr  Arg Ile Ser Phe Lys  Asn Asn Val 
    4985                 4990                 4995             


Ala Gln  Leu Lys Phe Tyr Ser  Ala Glu Leu His Asp  Ser Gly Gln 
    5000                 5005                 5010             


Tyr Thr  Phe Glu Ile Ser Asn  Glu Val Gly Ser Ser  Ser Cys Glu 
    5015                 5020                 5025             


Thr Thr  Phe Thr Val Leu Asp  Arg Asp Ile Ala Pro  Phe Phe Thr 
    5030                 5035                 5040             


Lys Pro  Leu Arg Asn Val Asp  Ser Val Val Asn Gly  Thr Cys Arg 
    5045                 5050                 5055             


Leu Asp  Cys Lys Ile Ala Gly  Ser Leu Pro Met Arg  Val Ser Trp 
    5060                 5065                 5070             


Phe Lys  Asp Gly Lys Glu Ile  Ala Ala Ser Asp Arg  Tyr Arg Ile 
    5075                 5080                 5085             


Ala Phe  Val Glu Gly Thr Ala  Ser Leu Glu Ile Ile  Arg Val Asp 
    5090                 5095                 5100             


Met Asn  Asp Ala Gly Asn Phe  Thr Cys Arg Ala Thr  Asn Ser Val 
    5105                 5110                 5115             


Gly Ser  Lys Asp Ser Ser Gly  Ala Leu Ile Val Gln  Glu Pro Pro 
    5120                 5125                 5130             


Ser Phe  Val Thr Lys Pro Gly  Ser Lys Asp Val Leu  Pro Gly Ser 
    5135                 5140                 5145             


Ala Val  Cys Leu Lys Ser Thr  Phe Gln Gly Ser Thr  Pro Leu Thr 
    5150                 5155                 5160             


Ile Arg  Trp Phe Lys Gly Asn  Lys Glu Leu Val Ser  Gly Gly Ser 
    5165                 5170                 5175             


Cys Tyr  Ile Thr Lys Glu Ala  Leu Glu Ser Ser Leu  Glu Leu Tyr 
    5180                 5185                 5190             


Leu Val  Lys Thr Ser Asp Ser  Gly Thr Tyr Thr Cys  Lys Val Ser 
    5195                 5200                 5205             


Asn Val  Ala Gly Gly Val Glu  Cys Ser Ala Asn Leu  Phe Val Lys 
    5210                 5215                 5220             


Glu Pro  Ala Thr Phe Val Glu  Lys Leu Glu Pro Ser  Gln Leu Leu 
    5225                 5230                 5235             


Lys Lys  Gly Asp Ala Thr Gln  Leu Ala Cys Lys Val  Thr Gly Thr 
    5240                 5245                 5250             


Pro Pro  Ile Lys Ile Thr Trp  Phe Ala Asn Asp Arg  Glu Ile Lys 
    5255                 5260                 5265             


Glu Ser  Ser Lys His Arg Met  Ser Phe Val Glu Ser  Thr Ala Val 
    5270                 5275                 5280             


Leu Arg  Leu Thr Asp Val Gly  Ile Glu Asp Ser Gly  Glu Tyr Met 
    5285                 5290                 5295             


Cys Glu  Ala Gln Asn Glu Ala  Gly Ser Asp His Cys  Ser Ser Ile 
    5300                 5305                 5310             


Val Ile  Val Lys Glu Ser Pro  Tyr Phe Thr Lys Glu  Phe Lys Pro 
    5315                 5320                 5325             


Ile Glu  Val Leu Lys Glu Tyr  Asp Val Met Leu Leu  Ala Glu Val 
    5330                 5335                 5340             


Ala Gly  Thr Pro Pro Phe Glu  Ile Thr Trp Phe Lys  Asp Asn Thr 
    5345                 5350                 5355             


Ile Leu  Arg Ser Gly Arg Lys  Tyr Lys Thr Phe Ile  Gln Asp His 
    5360                 5365                 5370             


Leu Val  Ser Leu Gln Ile Leu  Lys Phe Val Ala Ala  Asp Ala Gly 
    5375                 5380                 5385             


Glu Tyr  Gln Cys Arg Val Thr  Asn Glu Val Gly Ser  Ser Ile Cys 
    5390                 5395                 5400             


Ser Ala  Arg Val Thr Leu Arg  Glu Pro Pro Ser Phe  Ile Lys Lys 
    5405                 5410                 5415             


Ile Glu  Ser Thr Ser Ser Leu  Arg Gly Gly Thr Ala  Ala Phe Gln 
    5420                 5425                 5430             


Ala Thr  Leu Lys Gly Ser Leu  Pro Ile Thr Val Thr  Trp Leu Lys 
    5435                 5440                 5445             


Asp Ser  Asp Glu Ile Thr Glu  Asp Asp Asn Ile Arg  Met Thr Phe 
    5450                 5455                 5460             


Glu Asn  Asn Val Ala Ser Leu  Tyr Leu Ser Gly Ile  Glu Val Lys 
    5465                 5470                 5475             


His Asp  Gly Lys Tyr Val Cys  Gln Ala Lys Asn Asp  Ala Gly Ile 
    5480                 5485                 5490             


Gln Arg  Cys Ser Ala Leu Leu  Ser Val Lys Glu Pro  Ala Thr Ile 
    5495                 5500                 5505             


Thr Glu  Glu Ala Val Ser Ile  Asp Val Thr Gln Gly  Asp Pro Ala 
    5510                 5515                 5520             


Thr Leu  Gln Val Lys Phe Ser  Gly Thr Lys Glu Ile  Thr Ala Lys 
    5525                 5530                 5535             


Trp Phe  Lys Asp Gly Gln Glu  Leu Thr Leu Gly Ser  Lys Tyr Lys 
    5540                 5545                 5550             


Ile Ser  Val Thr Asp Thr Val  Ser Ile Leu Lys Ile  Ile Ser Thr 
    5555                 5560                 5565             


Glu Lys  Lys Asp Ser Gly Glu  Tyr Thr Phe Glu Val  Gln Asn Asp 
    5570                 5575                 5580             


Val Gly  Arg Ser Ser Cys Lys  Ala Arg Ile Asn Val  Leu Asp Leu 
    5585                 5590                 5595             


Ile Ile  Pro Pro Ser Phe Thr  Lys Lys Leu Lys Lys  Met Asp Ser 
    5600                 5605                 5610             


Ile Lys  Gly Ser Phe Ile Asp  Leu Glu Cys Ile Val  Ala Gly Ser 
    5615                 5620                 5625             


His Pro  Ile Ser Ile Gln Trp  Phe Lys Asp Asp Gln  Glu Ile Ser 
    5630                 5635                 5640             


Ala Ser  Glu Lys Tyr Lys Phe  Ser Phe His Asp Asn  Thr Ala Phe 
    5645                 5650                 5655             


Leu Glu  Ile Ser Gln Leu Glu  Gly Thr Asp Ser Gly  Thr Tyr Thr 
    5660                 5665                 5670             


Cys Ser  Ala Thr Asn Lys Ala  Gly His Asn Gln Cys  Ser Gly His 
    5675                 5680                 5685             


Leu Thr  Val Lys Glu Pro Pro  Tyr Phe Val Glu Lys  Pro Gln Ser 
    5690                 5695                 5700             


Gln Asp  Val Asn Pro Asn Thr  Arg Val Gln Leu Lys  Ala Leu Val 
    5705                 5710                 5715             


Gly Gly  Thr Ala Pro Met Thr  Ile Lys Trp Phe Lys  Asp Asn Lys 
    5720                 5725                 5730             


Glu Leu  His Ser Gly Ala Ala  Arg Ser Val Trp Lys  Asp Asp Thr 
    5735                 5740                 5745             


Ser Thr  Ser Leu Glu Leu Phe  Ala Ala Lys Ala Thr  Asp Ser Gly 
    5750                 5755                 5760             


Thr Tyr  Ile Cys Gln Leu Ser  Asn Asp Val Gly Thr  Ala Thr Ser 
    5765                 5770                 5775             


Lys Ala  Thr Leu Phe Val Lys  Glu Pro Pro Gln Phe  Ile Lys Lys 
    5780                 5785                 5790             


Pro Ser  Pro Val Leu Val Leu  Arg Asn Gly Gln Ser  Thr Thr Phe 
    5795                 5800                 5805             


Glu Cys  Gln Ile Thr Gly Thr  Pro Lys Ile Arg Val  Ser Trp Tyr 
    5810                 5815                 5820             


Leu Asp  Gly Asn Glu Ile Thr  Ala Ile Gln Lys His  Gly Ile Ser 
    5825                 5830                 5835             


Phe Ile  Asp Gly Leu Ala Thr  Phe Gln Ile Ser Gly  Ala Arg Val 
    5840                 5845                 5850             


Glu Asn  Ser Gly Thr Tyr Val  Cys Glu Ala Arg Asn  Asp Ala Gly 
    5855                 5860                 5865             


Thr Ala  Ser Cys Ser Ile Glu  Leu Lys Val Lys Glu  Pro Pro Thr 
    5870                 5875                 5880             


Phe Ile  Arg Glu Leu Lys Pro  Val Glu Val Val Lys  Tyr Ser Asp 
    5885                 5890                 5895             


Val Glu  Leu Glu Cys Glu Val  Thr Gly Thr Pro Pro  Phe Glu Val 
    5900                 5905                 5910             


Thr Trp  Leu Lys Asn Asn Arg  Glu Ile Arg Ser Ser  Lys Lys Tyr 
    5915                 5920                 5925             


Thr Leu  Thr Asp Arg Val Ser  Val Phe Asn Leu His  Ile Thr Lys 
    5930                 5935                 5940             


Cys Asp  Pro Ser Asp Thr Gly  Glu Tyr Gln Cys Ile  Val Ser Asn 
    5945                 5950                 5955             


Glu Gly  Gly Ser Cys Ser Cys  Ser Thr Arg Val Ala  Leu Lys Glu 
    5960                 5965                 5970             


Pro Pro  Ser Phe Ile Lys Lys  Ile Glu Asn Thr Thr  Thr Val Leu 
    5975                 5980                 5985             


Lys Ser  Ser Ala Thr Phe Gln  Ser Thr Val Ala Gly  Ser Pro Pro 
    5990                 5995                 6000             


Ile Ser  Ile Thr Trp Leu Lys  Asp Asp Gln Ile Leu  Asp Glu Asp 
    6005                 6010                 6015             


Asp Asn  Val Tyr Ile Ser Phe  Val Asp Ser Val Ala  Thr Leu Gln 
    6020                 6025                 6030             


Ile Arg  Ser Val Asp Asn Gly  His Ser Gly Arg Tyr  Thr Cys Gln 
    6035                 6040                 6045             


Ala Lys  Asn Glu Ser Gly Val  Glu Arg Cys Tyr Ala  Phe Leu Leu 
    6050                 6055                 6060             


Val Gln  Glu Pro Ala Gln Ile  Val Glu Lys Ala Lys  Ser Val Asp 
    6065                 6070                 6075             


Val Thr  Glu Lys Asp Pro Met  Thr Leu Glu Cys Val  Val Ala Gly 
    6080                 6085                 6090             


Thr Pro  Glu Leu Lys Val Lys  Trp Leu Lys Asp Gly  Lys Gln Ile 
    6095                 6100                 6105             


Val Pro  Ser Arg Tyr Phe Ser  Met Ser Phe Glu Asn  Asn Val Ala 
    6110                 6115                 6120             


Ser Phe  Arg Ile Gln Ser Val  Met Lys Gln Asp Ser  Gly Gln Tyr 
    6125                 6130                 6135             


Thr Phe  Lys Val Glu Asn Asp  Phe Gly Ser Ser Ser  Cys Asp Ala 
    6140                 6145                 6150             


Tyr Leu  Arg Val Leu Asp Gln  Asn Ile Pro Pro Ser  Phe Thr Lys 
    6155                 6160                 6165             


Lys Leu  Thr Lys Met Asp Lys  Val Leu Gly Ser Ser  Ile His Met 
    6170                 6175                 6180             


Glu Cys  Lys Val Ser Gly Ser  Leu Pro Ile Ser Ala  Gln Trp Phe 
    6185                 6190                 6195             


Lys Asp  Gly Lys Glu Ile Ser  Thr Ser Ala Lys Tyr  Arg Leu Val 
    6200                 6205                 6210             


Cys His  Glu Arg Ser Val Ser  Leu Glu Val Asn Asn  Leu Glu Leu 
    6215                 6220                 6225             


Glu Asp  Thr Ala Asn Tyr Thr  Cys Lys Val Ser Asn  Val Ala Gly 
    6230                 6235                 6240             


Asp Asp  Ala Cys Ser Gly Ile  Leu Thr Val Lys Glu  Pro Pro Ser 
    6245                 6250                 6255             


Phe Leu  Val Lys Pro Gly Arg  Gln Gln Ala Ile Pro  Asp Ser Thr 
    6260                 6265                 6270             


Val Glu  Phe Lys Ala Ile Leu  Lys Gly Thr Pro Pro  Phe Lys Ile 
    6275                 6280                 6285             


Lys Trp  Phe Lys Asp Asp Val  Glu Leu Val Ser Gly  Pro Lys Cys 
    6290                 6295                 6300             


Phe Ile  Gly Leu Glu Gly Ser  Thr Ser Phe Leu Asn  Leu Tyr Ser 
    6305                 6310                 6315             


Val Asp  Ala Ser Lys Thr Gly  Gln Tyr Thr Cys His  Val Thr Asn 
    6320                 6325                 6330             


Asp Val  Gly Ser Asp Ser Cys  Thr Thr Met Leu Leu  Val Thr Glu 
    6335                 6340                 6345             


Pro Pro  Lys Phe Val Lys Lys  Leu Glu Ala Ser Lys  Ile Val Lys 
    6350                 6355                 6360             


Ala Gly  Asp Ser Ser Arg Leu  Glu Cys Lys Ile Ala  Gly Ser Pro 
    6365                 6370                 6375             


Glu Ile  Arg Val Val Trp Phe  Arg Asn Glu His Glu  Leu Pro Ala 
    6380                 6385                 6390             


Ser Asp  Lys Tyr Arg Met Thr  Phe Ile Asp Ser Val  Ala Val Ile 
    6395                 6400                 6405             


Gln Met  Asn Asn Leu Ser Thr  Glu Asp Ser Gly Asp  Phe Ile Cys 
    6410                 6415                 6420             


Glu Ala  Gln Asn Pro Ala Gly  Ser Thr Ser Cys Ser  Thr Lys Val 
    6425                 6430                 6435             


Ile Val  Lys Glu Pro Pro Val  Phe Ser Ser Phe Pro  Pro Ile Val 
    6440                 6445                 6450             


Glu Thr  Leu Lys Asn Ala Glu  Val Ser Leu Glu Cys  Glu Leu Ser 
    6455                 6460                 6465             


Gly Thr  Pro Pro Phe Glu Val  Val Trp Tyr Lys Asp  Lys Arg Gln 
    6470                 6475                 6480             


Leu Arg  Ser Ser Lys Lys Tyr  Lys Ile Ala Ser Lys  Asn Phe His 
    6485                 6490                 6495             


Thr Ser  Ile His Ile Leu Asn  Val Asp Thr Ser Asp  Ile Gly Glu 
    6500                 6505                 6510             


Tyr His  Cys Lys Ala Gln Asn  Glu Val Gly Ser Asp  Thr Cys Val 
    6515                 6520                 6525             


Cys Thr  Val Lys Leu Lys Glu  Pro Pro Arg Phe Val  Ser Lys Leu 
    6530                 6535                 6540             


Asn Ser  Leu Thr Val Val Ala  Gly Glu Pro Ala Glu  Leu Gln Ala 
    6545                 6550                 6555             


Ser Ile  Glu Gly Ala Gln Pro  Ile Phe Val Gln Trp  Leu Lys Glu 
    6560                 6565                 6570             


Lys Glu  Glu Val Ile Arg Glu  Ser Glu Asn Ile Arg  Ile Thr Phe 
    6575                 6580                 6585             


Val Glu  Asn Val Ala Thr Leu  Gln Phe Ala Lys Ala  Glu Pro Ala 
    6590                 6595                 6600             


Asn Ala  Gly Lys Tyr Ile Cys  Gln Ile Lys Asn Asp  Gly Gly Met 
    6605                 6610                 6615             


Glu Glu  Asn Met Ala Thr Leu  Met Val Leu Glu Pro  Ala Val Ile 
    6620                 6625                 6630             


Val Glu  Lys Ala Gly Pro Met  Thr Val Thr Val Gly  Glu Thr Cys 
    6635                 6640                 6645             


Thr Leu  Glu Cys Lys Val Ala  Gly Thr Pro Glu Leu  Ser Val Glu 
    6650                 6655                 6660             


Trp Tyr  Lys Asp Gly Lys Leu  Leu Thr Ser Ser Gln  Lys His Lys 
    6665                 6670                 6675             


Phe Ser  Phe Tyr Asn Lys Ile  Ser Ser Leu Arg Ile  Leu Ser Val 
    6680                 6685                 6690             


Glu Arg  Gln Asp Ala Gly Thr  Tyr Thr Phe Gln Val  Gln Asn Asn 
    6695                 6700                 6705             


Val Gly  Lys Ser Ser Cys Thr  Ala Val Val Asp Val  Ser Asp Arg 
    6710                 6715                 6720             


Ala Val  Pro Pro Ser Phe Thr  Arg Arg Leu Lys Asn  Thr Gly Gly 
    6725                 6730                 6735             


Val Leu  Gly Ala Ser Cys Ile  Leu Glu Cys Lys Val  Ala Gly Ser 
    6740                 6745                 6750             


Ser Pro  Ile Ser Val Ala Trp  Phe His Glu Lys Thr  Lys Ile Val 
    6755                 6760                 6765             


Ser Gly  Ala Lys Tyr Gln Thr  Thr Phe Ser Asp Asn  Val Cys Thr 
    6770                 6775                 6780             


Leu Gln  Leu Asn Ser Leu Asp  Ser Ser Asp Met Gly  Asn Tyr Thr 
    6785                 6790                 6795             


Cys Val  Ala Ala Asn Val Ala  Gly Ser Asp Glu Cys  Arg Ala Val 
    6800                 6805                 6810             


Leu Thr  Val Gln Glu Pro Pro  Ser Phe Val Lys Glu  Pro Glu Pro 
    6815                 6820                 6825             


Leu Glu  Val Leu Pro Gly Lys  Asn Val Thr Phe Thr  Ser Val Ile 
    6830                 6835                 6840             


Arg Gly  Thr Pro Pro Phe Lys  Val Asn Trp Phe Arg  Gly Ala Arg 
    6845                 6850                 6855             


Glu Leu  Val Lys Gly Asp Arg  Cys Asn Ile Tyr Phe  Glu Asp Thr 
    6860                 6865                 6870             


Val Ala  Glu Leu Glu Leu Phe  Asn Ile Asp Ile Ser  Gln Ser Gly 
    6875                 6880                 6885             


Glu Tyr  Thr Cys Val Val Ser  Asn Asn Ala Gly Gln  Ala Ser Cys 
    6890                 6895                 6900             


Thr Thr  Arg Leu Phe Val Lys  Glu Pro Ala Ala Phe  Leu Lys Arg 
    6905                 6910                 6915             


Leu Ser  Asp His Ser Val Glu  Pro Gly Lys Ser Ile  Ile Leu Glu 
    6920                 6925                 6930             


Ser Thr  Tyr Thr Gly Thr Leu  Pro Ile Ser Val Thr  Trp Lys Lys 
    6935                 6940                 6945             


Asp Gly  Phe Asn Ile Thr Thr  Ser Glu Lys Cys Asn  Ile Val Thr 
    6950                 6955                 6960             


Thr Glu  Lys Thr Cys Ile Leu  Glu Ile Leu Asn Ser  Thr Lys Arg 
    6965                 6970                 6975             


Asp Ala  Gly Gln Tyr Ser Cys  Glu Ile Glu Asn Glu  Ala Gly Arg 
    6980                 6985                 6990             


Asp Val  Cys Gly Ala Leu Val  Ser Thr Leu Glu Pro  Pro Tyr Phe 
    6995                 7000                 7005             


Val Thr  Glu Leu Glu Pro Leu  Glu Ala Ala Val Gly  Asp Ser Val 
    7010                 7015                 7020             


Ser Leu  Gln Cys Gln Val Ala  Gly Thr Pro Glu Ile  Thr Val Ser 
    7025                 7030                 7035             


Trp Tyr  Lys Gly Asp Thr Lys  Leu Arg Pro Thr Pro  Glu Tyr Arg 
    7040                 7045                 7050             


Thr Tyr  Phe Thr Asn Asn Val  Ala Thr Leu Val Phe  Asn Lys Val 
    7055                 7060                 7065             


Asn Ile  Asn Asp Ser Gly Glu  Tyr Thr Cys Lys Ala  Glu Asn Ser 
    7070                 7075                 7080             


Ile Gly  Thr Ala Ser Ser Lys  Thr Val Phe Arg Ile  Gln Glu Arg 
    7085                 7090                 7095             


Gln Leu  Pro Pro Ser Phe Ala  Arg Gln Leu Lys Asp  Ile Glu Gln 
    7100                 7105                 7110             


Thr Val  Gly Leu Pro Val Thr  Leu Thr Cys Arg Leu  Asn Gly Ser 
    7115                 7120                 7125             


Ala Pro  Ile Gln Val Cys Trp  Tyr Arg Asp Gly Val  Leu Leu Arg 
    7130                 7135                 7140             


Asp Asp  Glu Asn Leu Gln Thr  Ser Phe Val Asp Asn  Val Ala Thr 
    7145                 7150                 7155             


Leu Lys  Ile Leu Gln Thr Asp  Leu Ser His Ser Gly  Gln Tyr Ser 
    7160                 7165                 7170             


Cys Ser  Ala Ser Asn Pro Leu  Gly Thr Ala Ser Ser  Ser Ala Arg 
    7175                 7180                 7185             


Leu Thr  Ala Arg Glu Pro Lys  Lys Ser Pro Phe Phe  Asp Ile Lys 
    7190                 7195                 7200             


Pro Val  Ser Ile Asp Val Ile  Ala Gly Glu Ser Ala  Asp Phe Glu 
    7205                 7210                 7215             


Cys His  Val Thr Gly Ala Gln  Pro Met Arg Ile Thr  Trp Ser Lys 
    7220                 7225                 7230             


Asp Asn  Lys Glu Ile Arg Pro  Gly Gly Asn Tyr Thr  Ile Thr Cys 
    7235                 7240                 7245             


Val Gly  Asn Thr Pro His Leu  Arg Ile Leu Lys Val  Gly Lys Gly 
    7250                 7255                 7260             


Asp Ser  Gly Gln Tyr Thr Cys  Gln Ala Thr Asn Asp  Val Gly Lys 
    7265                 7270                 7275             


Asp Met  Cys Ser Ala Gln Leu  Ser Val Lys Glu Pro  Pro Lys Phe 
    7280                 7285                 7290             


Val Lys  Lys Leu Glu Ala Ser  Lys Val Ala Lys Gln  Gly Glu Ser 
    7295                 7300                 7305             


Ile Gln  Leu Glu Cys Lys Ile  Ser Gly Ser Pro Glu  Ile Lys Val 
    7310                 7315                 7320             


Ser Trp  Phe Arg Asn Asp Ser  Glu Leu His Glu Ser  Trp Lys Tyr 
    7325                 7330                 7335             


Asn Met  Ser Phe Ile Asn Ser  Val Ala Leu Leu Thr  Ile Asn Glu 
    7340                 7345                 7350             


Ala Ser  Ala Glu Asp Ser Gly  Asp Tyr Ile Cys Glu  Ala His Asn 
    7355                 7360                 7365             


Gly Val  Gly Asp Ala Ser Cys  Ser Thr Ala Leu Thr  Val Lys Ala 
    7370                 7375                 7380             


Pro Pro  Val Phe Thr Gln Lys  Pro Ser Pro Val Gly  Ala Leu Lys 
    7385                 7390                 7395             


Gly Ser  Asp Val Ile Leu Gln  Cys Glu Ile Ser Gly  Thr Pro Pro 
    7400                 7405                 7410             


Phe Glu  Val Val Trp Val Lys  Asp Arg Lys Gln Val  Arg Asn Ser 
    7415                 7420                 7425             


Lys Lys  Phe Lys Ile Thr Ser  Lys His Phe Asp Thr  Ser Leu His 
    7430                 7435                 7440             


Ile Leu  Asn Leu Glu Ala Ser  Asp Val Gly Glu Tyr  His Cys Lys 
    7445                 7450                 7455             


Ala Thr  Asn Glu Val Gly Ser  Asp Thr Cys Ser Cys  Ser Val Lys 
    7460                 7465                 7470             


Phe Lys  Glu Pro Pro Arg Phe  Val Lys Lys Leu Ser  Asp Thr Ser 
    7475                 7480                 7485             


Thr Leu  Ile Gly Asp Ala Val  Glu Leu Arg Ala Ile  Val Glu Gly 
    7490                 7495                 7500             


Phe Gln  Pro Ile Ser Val Val  Trp Leu Lys Asp Arg  Gly Glu Val 
    7505                 7510                 7515             


Ile Arg  Glu Ser Glu Asn Thr  Arg Ile Ser Phe Ile  Asp Asn Ile 
    7520                 7525                 7530             


Ala Thr  Leu Gln Leu Gly Ser  Pro Glu Ala Ser Asn  Ser Gly Lys 
    7535                 7540                 7545             


Tyr Ile  Cys Gln Ile Lys Asn  Asp Ala Gly Met Arg  Glu Cys Ser 
    7550                 7555                 7560             


Ala Val  Leu Thr Val Leu Glu  Pro Ala Arg Ile Ile  Glu Lys Pro 
    7565                 7570                 7575             


Glu Pro  Met Thr Val Thr Thr  Gly Asn Pro Phe Ala  Leu Glu Cys 
    7580                 7585                 7590             


Val Val  Thr Gly Thr Pro Glu  Leu Ser Ala Lys Trp  Phe Lys Asp 
    7595                 7600                 7605             


Gly Arg  Glu Leu Ser Ala Asp  Ser Lys His His Ile  Thr Phe Ile 
    7610                 7615                 7620             


Asn Lys  Val Ala Ser Leu Lys  Ile Pro Cys Ala Glu  Met Ser Asp 
    7625                 7630                 7635             


Lys Gly  Leu Tyr Ser Phe Glu  Val Lys Asn Ser Val  Gly Lys Ser 
    7640                 7645                 7650             


Asn Cys  Thr Val Ser Val His  Val Ser Asp Arg Ile  Val Pro Pro 
    7655                 7660                 7665             


Ser Phe  Ile Arg Lys Leu Lys  Asp Val Asn Ala Ile  Leu Gly Ala 
    7670                 7675                 7680             


Ser Val  Val Leu Glu Cys Arg  Val Ser Gly Ser Ala  Pro Ile Ser 
    7685                 7690                 7695             


Val Gly  Trp Phe Gln Asp Gly  Asn Glu Ile Val Ser  Gly Pro Lys 
    7700                 7705                 7710             


Cys Gln  Ser Ser Phe Ser Glu  Asn Val Cys Thr Leu  Asn Leu Ser 
    7715                 7720                 7725             


Leu Leu  Glu Pro Ser Asp Thr  Gly Ile Tyr Thr Cys  Val Ala Ala 
    7730                 7735                 7740             


Asn Val  Ala Gly Ser Asp Glu  Cys Ser Ala Val Leu  Thr Val Gln 
    7745                 7750                 7755             


Glu Pro  Pro Ser Phe Glu Gln  Thr Pro Asp Ser Val  Glu Val Leu 
    7760                 7765                 7770             


Pro Gly  Met Ser Leu Thr Phe  Thr Ser Val Ile Arg  Gly Thr Pro 
    7775                 7780                 7785             


Pro Phe  Lys Val Lys Trp Phe  Lys Gly Ser Arg Glu  Leu Val Pro 
    7790                 7795                 7800             


Gly Glu  Ser Cys Asn Ile Ser  Leu Glu Asp Phe Val  Thr Glu Leu 
    7805                 7810                 7815             


Glu Leu  Phe Glu Val Gln Pro  Leu Glu Ser Gly Asp  Tyr Ser Cys 
    7820                 7825                 7830             


Leu Val  Thr Asn Asp Ala Gly  Ser Ala Ser Cys Thr  Thr His Leu 
    7835                 7840                 7845             


Phe Val  Lys Glu Pro Ala Thr  Phe Val Lys Arg Leu  Ala Asp Phe 
    7850                 7855                 7860             


Ser Val  Glu Thr Gly Ser Pro  Ile Val Leu Glu Ala  Thr Tyr Thr 
    7865                 7870                 7875             


Gly Thr  Pro Pro Ile Ser Val  Ser Trp Ile Lys Asp  Glu Tyr Leu 
    7880                 7885                 7890             


Ile Ser  Gln Ser Glu Arg Cys  Ser Ile Thr Met Thr  Glu Lys Ser 
    7895                 7900                 7905             


Thr Ile  Leu Glu Ile Leu Glu  Ser Thr Ile Glu Asp  Tyr Ala Gln 
    7910                 7915                 7920             


Tyr Ser  Cys Leu Ile Glu Asn  Glu Ala Gly Gln Asp  Ile Cys Glu 
    7925                 7930                 7935             


Ala Leu  Val Ser Val Leu Glu  Pro Pro Tyr Phe Ile  Glu Pro Leu 
    7940                 7945                 7950             


Glu His  Val Glu Ala Val Ile  Gly Glu Pro Ala Thr  Leu Gln Cys 
    7955                 7960                 7965             


Lys Val  Asp Gly Thr Pro Glu  Ile Arg Ile Ser Trp  Tyr Lys Glu 
    7970                 7975                 7980             


His Thr  Lys Leu Arg Ser Ala  Pro Ala Tyr Lys Met  Gln Phe Lys 
    7985                 7990                 7995             


Asn Asn  Val Ala Ser Leu Val  Ile Asn Lys Val Asp  His Ser Asp 
    8000                 8005                 8010             


Val Gly  Glu Tyr Ser Cys Lys  Ala Asp Asn Ser Val  Gly Ala Val 
    8015                 8020                 8025             


Ala Ser  Ser Ala Val Leu Val  Ile Lys Glu Arg Lys  Leu Pro Pro 
    8030                 8035                 8040             


Phe Phe  Ala Arg Lys Leu Lys  Asp Val His Glu Thr  Leu Gly Phe 
    8045                 8050                 8055             


Pro Val  Ala Phe Glu Cys Arg  Ile Asn Gly Ser Glu  Pro Leu Gln 
    8060                 8065                 8070             


Val Ser  Trp Tyr Lys Asp Gly  Val Leu Leu Lys Asp  Asp Ala Asn 
    8075                 8080                 8085             


Leu Gln  Thr Ser Phe Val His  Asn Val Ala Thr Leu  Gln Ile Leu 
    8090                 8095                 8100             


Gln Thr  Asp Gln Ser His Ile  Gly Gln Tyr Asn Cys  Ser Ala Ser 
    8105                 8110                 8115             


Asn Pro  Leu Gly Thr Ala Ser  Ser Ser Ala Lys Leu  Ile Leu Ser 
    8120                 8125                 8130             


Glu His  Glu Val Pro Pro Phe  Phe Asp Leu Lys Pro  Val Ser Val 
    8135                 8140                 8145             


Asp Leu  Ala Leu Gly Glu Ser  Gly Thr Phe Lys Cys  His Val Thr 
    8150                 8155                 8160             


Gly Thr  Ala Pro Ile Lys Ile  Thr Trp Ala Lys Asp  Asn Arg Glu 
    8165                 8170                 8175             


Ile Arg  Pro Gly Gly Asn Tyr  Lys Met Thr Leu Val  Glu Asn Thr 
    8180                 8185                 8190             


Ala Thr  Leu Thr Val Leu Lys  Val Gly Lys Gly Asp  Ala Gly Gln 
    8195                 8200                 8205             


Tyr Thr  Cys Tyr Ala Ser Asn  Ile Ala Gly Lys Asp  Ser Cys Ser 
    8210                 8215                 8220             


Ala His  Leu Gly Val Gln Glu  Pro Pro Arg Phe Ile  Lys Lys Leu 
    8225                 8230                 8235             


Glu Pro  Ser Arg Ile Val Lys  Gln Asp Glu Phe Thr  Arg Tyr Glu 
    8240                 8245                 8250             


Cys Lys  Ile Gly Gly Ser Pro  Glu Ile Lys Val Leu  Trp Tyr Lys 
    8255                 8260                 8265             


Asp Glu  Thr Glu Ile Gln Glu  Ser Ser Lys Phe Arg  Met Ser Phe 
    8270                 8275                 8280             


Val Asp  Ser Val Ala Val Leu  Glu Met His Asn Leu  Ser Val Glu 
    8285                 8290                 8295             


Asp Ser  Gly Asp Tyr Thr Cys  Glu Ala His Asn Ala  Ala Gly Ser 
    8300                 8305                 8310             


Ala Ser  Ser Ser Thr Ser Leu  Lys Val Lys Glu Pro  Pro Ile Phe 
    8315                 8320                 8325             


Arg Lys  Lys Pro His Pro Ile  Glu Thr Leu Lys Gly  Ala Asp Val 
    8330                 8335                 8340             


His Leu  Glu Cys Glu Leu Gln  Gly Thr Pro Pro Phe  His Val Ser 
    8345                 8350                 8355             


Trp Tyr  Lys Asp Lys Arg Glu  Leu Arg Ser Gly Lys  Lys Tyr Lys 
    8360                 8365                 8370             


Ile Met  Ser Glu Asn Phe Leu  Thr Ser Ile His Ile  Leu Asn Val 
    8375                 8380                 8385             


Asp Ala  Ala Asp Ile Gly Glu  Tyr Gln Cys Lys Ala  Thr Asn Asp 
    8390                 8395                 8400             


Val Gly  Ser Asp Thr Cys Val  Gly Ser Ile Ala Leu  Lys Ala Pro 
    8405                 8410                 8415             


Pro Arg  Phe Val Lys Lys Leu  Ser Asp Ile Ser Thr  Val Val Gly 
    8420                 8425                 8430             


Lys Glu  Val Gln Leu Gln Thr  Thr Ile Glu Gly Ala  Glu Pro Ile 
    8435                 8440                 8445             


Ser Val  Val Trp Phe Lys Asp  Lys Gly Glu Ile Val  Arg Glu Ser 
    8450                 8455                 8460             


Asp Asn  Ile Trp Ile Ser Tyr  Ser Glu Asn Ile Ala  Thr Leu Gln 
    8465                 8470                 8475             


Phe Ser  Arg Val Glu Pro Ala  Asn Ala Gly Lys Tyr  Thr Cys Gln 
    8480                 8485                 8490             


Ile Lys  Asn Asp Ala Gly Met  Gln Glu Cys Phe Ala  Thr Leu Ser 
    8495                 8500                 8505             


Val Leu  Glu Pro Ala Thr Ile  Val Glu Lys Pro Glu  Ser Ile Lys 
    8510                 8515                 8520             


Val Thr  Thr Gly Asp Thr Cys  Thr Leu Glu Cys Thr  Val Ala Gly 
    8525                 8530                 8535             


Thr Pro  Glu Leu Ser Thr Lys  Trp Phe Lys Asp Gly  Lys Glu Leu 
    8540                 8545                 8550             


Thr Ser  Asp Asn Lys Tyr Lys  Ile Ser Phe Phe Asn  Lys Val Ser 
    8555                 8560                 8565             


Gly Leu  Lys Ile Ile Asn Val  Ala Pro Ser Asp Ser  Gly Val Tyr 
    8570                 8575                 8580             


Ser Phe  Glu Val Gln Asn Pro  Val Gly Lys Asp Ser  Cys Thr Ala 
    8585                 8590                 8595             


Ser Leu  Gln Val Ser Asp Arg  Thr Val Pro Pro Ser  Phe Thr Arg 
    8600                 8605                 8610             


Lys Leu  Lys Glu Thr Asn Gly  Leu Ser Gly Ser Ser  Val Val Met 
    8615                 8620                 8625             


Glu Cys  Lys Val Tyr Gly Ser  Pro Pro Ile Ser Val  Ser Trp Phe 
    8630                 8635                 8640             


His Glu  Gly Asn Glu Ile Ser  Ser Gly Arg Lys Tyr  Gln Thr Thr 
    8645                 8650                 8655             


Leu Thr  Asp Asn Thr Cys Ala  Leu Thr Val Asn Met  Leu Glu Glu 
    8660                 8665                 8670             


Ser Asp  Ser Gly Asp Tyr Thr  Cys Ile Ala Thr Asn  Met Ala Gly 
    8675                 8680                 8685             


Ser Asp  Glu Cys Ser Ala Pro  Leu Thr Val Arg Glu  Pro Pro Ser 
    8690                 8695                 8700             


Phe Val  Gln Lys Pro Asp Pro  Met Asp Val Leu Thr  Gly Thr Asn 
    8705                 8710                 8715             


Val Thr  Phe Thr Ser Ile Val  Lys Gly Thr Pro Pro  Phe Ser Val 
    8720                 8725                 8730             


Ser Trp  Phe Lys Gly Ser Ser  Glu Leu Val Pro Gly  Asp Arg Cys 
    8735                 8740                 8745             


Asn Val  Ser Leu Glu Asp Ser  Val Ala Glu Leu Glu  Leu Phe Asp 
    8750                 8755                 8760             


Val Asp  Thr Ser Gln Ser Gly  Glu Tyr Thr Cys Ile  Val Ser Asn 
    8765                 8770                 8775             


Glu Ala  Gly Lys Ala Ser Cys  Thr Thr His Leu Tyr  Ile Lys Ala 
    8780                 8785                 8790             


Pro Ala  Lys Phe Val Lys Arg  Leu Asn Asp Tyr Ser  Ile Glu Lys 
    8795                 8800                 8805             


Gly Lys  Pro Leu Ile Leu Glu  Gly Thr Phe Thr Gly  Thr Pro Pro 
    8810                 8815                 8820             


Ile Ser  Val Thr Trp Lys Lys  Asn Gly Ile Asn Val  Thr Pro Ser 
    8825                 8830                 8835             


Gln Arg  Cys Asn Ile Thr Thr  Thr Glu Lys Ser Ala  Ile Leu Glu 
    8840                 8845                 8850             


Ile Pro  Ser Ser Thr Val Glu  Asp Ala Gly Gln Tyr  Asn Cys Tyr 
    8855                 8860                 8865             


Ile Glu  Asn Ala Ser Gly Lys  Asp Ser Cys Ser Ala  Gln Ile Leu 
    8870                 8875                 8880             


Ile Leu  Glu Pro Pro Tyr Phe  Val Lys Gln Leu Glu  Pro Val Lys 
    8885                 8890                 8895             


Val Ser  Val Gly Asp Ser Ala  Ser Leu Gln Cys Gln  Leu Ala Gly 
    8900                 8905                 8910             


Thr Pro  Glu Ile Gly Val Ser  Trp Tyr Lys Gly Asp  Thr Lys Leu 
    8915                 8920                 8925             


Arg Pro  Thr Thr Thr Tyr Lys  Met His Phe Arg Asn  Asn Val Ala 
    8930                 8935                 8940             


Thr Leu  Val Phe Asn Gln Val  Asp Ile Asn Asp Ser  Gly Glu Tyr 
    8945                 8950                 8955             


Ile Cys  Lys Ala Glu Asn Ser  Val Gly Glu Val Ser  Ala Ser Thr 
    8960                 8965                 8970             


Phe Leu  Thr Val Gln Glu Gln  Lys Leu Pro Pro Ser  Phe Ser Arg 
    8975                 8980                 8985             


Gln Leu  Arg Asp Val Gln Glu  Thr Val Gly Leu Pro  Val Val Phe 
    8990                 8995                 9000             


Asp Cys  Ala Ile Ser Gly Ser  Glu Pro Ile Ser Val  Ser Trp Tyr 
    9005                 9010                 9015             


Lys Asp  Gly Lys Pro Leu Lys  Asp Ser Pro Asn Val  Gln Thr Ser 
    9020                 9025                 9030             


Phe Leu  Asp Asn Thr Ala Thr  Leu Asn Ile Phe Lys  Thr Asp Arg 
    9035                 9040                 9045             


Ser Leu  Ala Gly Gln Tyr Ser  Cys Thr Ala Thr Asn  Pro Ile Gly 
    9050                 9055                 9060             


Ser Ala  Ser Ser Ser Ala Arg  Leu Ile Leu Thr Glu  Gly Lys Asn 
    9065                 9070                 9075             


Pro Pro  Phe Phe Asp Ile Arg  Leu Ala Pro Val Asp  Ala Val Val 
    9080                 9085                 9090             


Gly Glu  Ser Ala Asp Phe Glu  Cys His Val Thr Gly  Thr Gln Pro 
    9095                 9100                 9105             


Ile Lys  Val Ser Trp Ala Lys  Asp Ser Arg Glu Ile  Arg Ser Gly 
    9110                 9115                 9120             


Gly Lys  Tyr Gln Ile Ser Tyr  Leu Glu Asn Ser Ala  His Leu Thr 
    9125                 9130                 9135             


Val Leu  Lys Val Asp Lys Gly  Asp Ser Gly Gln Tyr  Thr Cys Tyr 
    9140                 9145                 9150             


Ala Val  Asn Glu Val Gly Lys  Asp Ser Cys Thr Ala  Gln Leu Asn 
    9155                 9160                 9165             


Ile Lys  Glu Arg Leu Ile Pro  Pro Ser Phe Thr Lys  Arg Leu Ser 
    9170                 9175                 9180             


Glu Thr  Val Glu Glu Thr Glu  Gly Asn Ser Phe Lys  Leu Glu Gly 
    9185                 9190                 9195             


Arg Val  Ala Gly Ser Gln Pro  Ile Thr Val Ala Trp  Tyr Lys Asn 
    9200                 9205                 9210             


Asn Ile  Glu Ile Gln Pro Thr  Ser Asn Cys Glu Ile  Thr Phe Lys 
    9215                 9220                 9225             


Asn Asn  Thr Leu Val Leu Gln  Val Arg Lys Ala Gly  Met Asn Asp 
    9230                 9235                 9240             


Ala Gly  Leu Tyr Thr Cys Lys  Val Ser Asn Asp Ala  Gly Ser Ala 
    9245                 9250                 9255             


Leu Cys  Thr Ser Ser Ile Val  Ile Lys Glu Pro Lys  Lys Pro Pro 
    9260                 9265                 9270             


Val Phe  Asp Gln His Leu Thr  Pro Val Thr Val Ser  Glu Gly Glu 
    9275                 9280                 9285             


Tyr Val  Gln Leu Ser Cys His  Val Gln Gly Ser Glu  Pro Ile Arg 
    9290                 9295                 9300             


Ile Gln  Trp Leu Lys Ala Gly  Arg Glu Ile Lys Pro  Ser Asp Arg 
    9305                 9310                 9315             


Cys Ser  Phe Ser Phe Ala Ser  Gly Thr Ala Val Leu  Glu Leu Arg 
    9320                 9325                 9330             


Asp Val  Ala Lys Ala Asp Ser  Gly Asp Tyr Val Cys  Lys Ala Ser 
    9335                 9340                 9345             


Asn Val  Ala Gly Ser Asp Thr  Thr Lys Ser Lys Val  Thr Ile Lys 
    9350                 9355                 9360             


Asp Lys  Pro Ala Val Ala Pro  Ala Thr Lys Lys Ala  Ala Val Asp 
    9365                 9370                 9375             


Gly Arg  Leu Phe Phe Val Ser  Glu Pro Gln Ser Ile  Arg Val Val 
    9380                 9385                 9390             


Glu Lys  Thr Thr Ala Thr Phe  Ile Ala Lys Val Gly  Gly Asp Pro 
    9395                 9400                 9405             


Ile Pro  Asn Val Lys Trp Thr  Lys Gly Lys Trp Arg  Gln Leu Asn 
    9410                 9415                 9420             


Gln Gly  Gly Arg Val Phe Ile  His Gln Lys Gly Asp  Glu Ala Lys 
    9425                 9430                 9435             


Leu Glu  Ile Arg Asp Thr Thr  Lys Thr Asp Ser Gly  Leu Tyr Arg 
    9440                 9445                 9450             


Cys Val  Ala Phe Asn Glu His  Gly Glu Ile Glu Ser  Asn Val Asn 
    9455                 9460                 9465             


Leu Gln  Val Asp Glu Arg Lys  Lys Gln Glu Lys Ile  Glu Gly Asp 
    9470                 9475                 9480             


Leu Arg  Ala Met Leu Lys Lys  Thr Pro Ile Leu Lys  Lys Gly Ala 
    9485                 9490                 9495             


Gly Glu  Glu Glu Glu Ile Asp  Ile Met Glu Leu Leu  Lys Asn Val 
    9500                 9505                 9510             


Asp Pro  Lys Glu Tyr Glu Lys  Tyr Ala Arg Met Tyr  Gly Ile Thr 
    9515                 9520                 9525             


Asp Phe  Arg Gly Leu Leu Gln  Ala Phe Glu Leu Leu  Lys Gln Ser 
    9530                 9535                 9540             


Gln Glu  Glu Glu Thr His Arg  Leu Glu Ile Glu Glu  Ile Glu Arg 
    9545                 9550                 9555             


Ser Glu  Arg Asp Glu Lys Glu  Phe Glu Glu Leu Val  Ser Phe Ile 
    9560                 9565                 9570             


Gln Gln  Arg Leu Ser Gln Thr  Glu Pro Val Thr Leu  Ile Lys Asp 
    9575                 9580                 9585             


Ile Glu  Asn Gln Thr Val Leu  Lys Asp Asn Asp Ala  Val Phe Glu 
    9590                 9595                 9600             


Ile Asp  Ile Lys Ile Asn Tyr  Pro Glu Ile Lys Leu  Ser Trp Tyr 
    9605                 9610                 9615             


Lys Gly  Thr Glu Lys Leu Glu  Pro Ser Asp Lys Phe  Glu Ile Ser 
    9620                 9625                 9630             


Ile Asp  Gly Asp Arg His Thr  Leu Arg Val Lys Asn  Cys Gln Leu 
    9635                 9640                 9645             


Lys Asp  Gln Gly Asn Tyr Arg  Leu Val Cys Gly Pro  His Ile Ala 
    9650                 9655                 9660             


Ser Ala  Lys Leu Thr Val Ile  Glu Pro Ala Trp Glu  Arg His Leu 
    9665                 9670                 9675             


Gln Asp  Val Thr Leu Lys Glu  Gly Gln Thr Cys Thr  Met Thr Cys 
    9680                 9685                 9690             


Gln Phe  Ser Val Pro Asn Val  Lys Ser Glu Trp Phe  Arg Asn Gly 
    9695                 9700                 9705             


Arg Ile  Leu Lys Pro Gln Gly  Arg His Lys Thr Glu  Val Glu His 
    9710                 9715                 9720             


Lys Val  His Lys Leu Thr Ile  Ala Asp Val Arg Ala  Glu Asp Gln 
    9725                 9730                 9735             


Gly Gln  Tyr Thr Cys Lys Tyr  Glu Asp Leu Glu Thr  Ser Ala Glu 
    9740                 9745                 9750             


Leu Arg  Ile Glu Ala Glu Pro  Ile Gln Phe Thr Lys  Arg Ile Gln 
    9755                 9760                 9765             


Asn Ile  Val Val Ser Glu His  Gln Ser Ala Thr Phe  Glu Cys Glu 
    9770                 9775                 9780             


Val Ser  Phe Asp Asp Ala Ile  Val Thr Trp Tyr Lys  Gly Pro Thr 
    9785                 9790                 9795             


Glu Leu  Thr Glu Ser Gln Lys  Tyr Asn Phe Arg Asn  Asp Gly Arg 
    9800                 9805                 9810             


Cys His  Tyr Met Thr Ile His  Asn Val Thr Pro Asp  Asp Glu Gly 
    9815                 9820                 9825             


Val Tyr  Ser Val Ile Ala Arg  Leu Glu Pro Arg Gly  Glu Ala Arg 
    9830                 9835                 9840             


Ser Thr  Ala Glu Leu Tyr Leu  Thr Thr Lys Glu Ile  Lys Leu Glu 
    9845                 9850                 9855             


Leu Lys  Pro Pro Asp Ile Pro  Asp Ser Arg Val Pro  Ile Pro Thr 
    9860                 9865                 9870             


Met Pro  Ile Arg Ala Val Pro  Pro Glu Glu Ile Pro  Pro Val Val 
    9875                 9880                 9885             


Ala Pro  Pro Ile Pro Leu Leu  Leu Pro Thr Pro Glu  Glu Lys Lys 
    9890                 9895                 9900             


Pro Pro  Pro Lys Arg Ile Glu  Val Thr Lys Lys Ala  Val Lys Lys 
    9905                 9910                 9915             


Asp Ala  Lys Lys Val Val Ala  Lys Pro Lys Glu Met  Thr Pro Arg 
    9920                 9925                 9930             


Glu Glu  Ile Val Lys Lys Pro  Pro Pro Pro Thr Thr  Leu Ile Pro 
    9935                 9940                 9945             


Ala Lys  Ala Pro Glu Ile Ile  Asp Val Ser Ser Lys  Ala Glu Glu 
    9950                 9955                 9960             


Val Lys  Ile Met Thr Ile Thr  Arg Lys Lys Glu Val  Gln Lys Glu 
    9965                 9970                 9975             


Lys Glu  Ala Val Tyr Glu Lys  Lys Gln Ala Val His  Lys Glu Lys 
    9980                 9985                 9990             


Arg Val  Phe Ile Glu Ser Phe   Glu Glu Pro Tyr Asp   Glu Leu Glu 
    9995                 10000                 10005             


Val Glu   Pro Tyr Thr Glu Pro   Phe Glu Gln Pro Tyr   Tyr Glu Glu 
    10010                 10015                 10020             


Pro Asp   Glu Asp Tyr Glu Glu   Ile Lys Val Glu Ala   Lys Lys Glu 
    10025                 10030                 10035             


Val His   Glu Glu Trp Glu Glu   Asp Phe Glu Glu Gly   Gln Glu Tyr 
    10040                 10045                 10050             


Tyr Glu   Arg Glu Glu Gly Tyr   Asp Glu Gly Glu Glu   Glu Trp Glu 
    10055                 10060                 10065             


Glu Ala   Tyr Gln Glu Arg Glu   Val Ile Gln Val Gln   Lys Glu Val 
    10070                 10075                 10080             


Tyr Glu   Glu Ser His Glu Arg   Lys Val Pro Ala Lys   Val Pro Glu 
    10085                 10090                 10095             


Lys Lys   Ala Pro Pro Pro Pro   Lys Val Ile Lys Lys   Pro Val Ile 
    10100                 10105                 10110             


Glu Lys   Ile Glu Lys Thr Ser   Arg Arg Met Glu Glu   Glu Lys Val 
    10115                 10120                 10125             


Gln Val   Thr Lys Val Pro Glu   Val Ser Lys Lys Ile   Val Pro Gln 
    10130                 10135                 10140             


Lys Pro   Ser Arg Thr Pro Val   Gln Glu Glu Val Ile   Glu Val Lys 
    10145                 10150                 10155             


Val Pro   Ala Val His Thr Lys   Lys Met Val Ile Ser   Glu Glu Lys 
    10160                 10165                 10170             


Met Phe   Phe Ala Ser His Thr   Glu Glu Glu Val Ser   Val Thr Val 
    10175                 10180                 10185             


Pro Glu   Val Gln Lys Glu Ile   Val Thr Glu Glu Lys   Ile His Val 
    10190                 10195                 10200             


Ala Val   Ser Lys Arg Val Glu   Pro Pro Pro Lys Val   Pro Glu Leu 
    10205                 10210                 10215             


Pro Glu   Lys Pro Ala Pro Glu   Glu Val Ala Pro Val   Pro Ile Pro 
    10220                 10225                 10230             


Lys Lys   Val Glu Pro Pro Ala   Pro Lys Val Pro Glu   Val Pro Lys 
    10235                 10240                 10245             


Lys Pro   Val Pro Glu Glu Lys   Lys Pro Val Pro Val   Pro Lys Lys 
    10250                 10255                 10260             


Glu Pro   Ala Ala Pro Pro Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10265                 10270                 10275             


Val Pro   Glu Glu Lys Ile Pro   Val Pro Val Ala Lys   Lys Lys Glu 
    10280                 10285                 10290             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Gln Lys Arg   Val Val Thr 
    10295                 10300                 10305             


Glu Glu   Lys Ile Thr Ile Val   Thr Gln Arg Glu Glu   Ser Pro Pro 
    10310                 10315                 10320             


Pro Ala   Val Pro Glu Ile Pro   Lys Lys Lys Val Pro   Glu Glu Arg 
    10325                 10330                 10335             


Lys Pro   Val Pro Arg Lys Glu   Glu Glu Val Pro Pro   Pro Pro Lys 
    10340                 10345                 10350             


Val Pro   Ala Leu Pro Lys Lys   Pro Val Pro Glu Glu   Lys Val Ala 
    10355                 10360                 10365             


Val Pro   Val Pro Val Ala Lys   Lys Ala Pro Pro Pro   Arg Ala Glu 
    10370                 10375                 10380             


Val Ser   Lys Lys Thr Val Val   Glu Glu Lys Arg Phe   Val Ala Glu 
    10385                 10390                 10395             


Glu Lys   Leu Ser Phe Ala Val   Pro Gln Arg Val Glu   Val Thr Arg 
    10400                 10405                 10410             


His Glu   Val Ser Ala Glu Glu   Glu Trp Ser Tyr Ser   Glu Glu Glu 
    10415                 10420                 10425             


Glu Gly   Val Ser Ile Ser Val   Tyr Arg Glu Glu Glu   Arg Glu Glu 
    10430                 10435                 10440             


Glu Glu   Glu Ala Glu Val Thr   Glu Tyr Glu Val Met   Glu Glu Pro 
    10445                 10450                 10455             


Glu Glu   Tyr Val Val Glu Glu   Lys Leu His Ile Ile   Ser Lys Arg 
    10460                 10465                 10470             


Val Glu   Ala Glu Pro Ala Glu   Val Thr Glu Arg Gln   Glu Lys Lys 
    10475                 10480                 10485             


Ile Val   Leu Lys Pro Lys Ile   Pro Ala Lys Ile Glu   Glu Pro Pro 
    10490                 10495                 10500             


Pro Ala   Lys Val Pro Glu Ala   Pro Lys Lys Ile Val   Pro Glu Lys 
    10505                 10510                 10515             


Lys Val   Pro Ala Pro Val Pro   Lys Lys Glu Lys Val   Pro Pro Pro 
    10520                 10525                 10530             


Lys Val   Pro Glu Glu Pro Lys   Lys Pro Val Pro Glu   Lys Lys Val 
    10535                 10540                 10545             


Pro Pro   Lys Val Ile Lys Met   Glu Glu Pro Leu Pro   Ala Lys Val 
    10550                 10555                 10560             


Thr Glu   Arg His Met Gln Ile   Thr Gln Glu Glu Lys   Val Leu Val 
    10565                 10570                 10575             


Ala Val   Thr Lys Lys Glu Ala   Pro Pro Lys Ala Arg   Val Pro Glu 
    10580                 10585                 10590             


Glu Pro   Lys Arg Ala Val Pro   Glu Glu Lys Val Leu   Lys Leu Lys 
    10595                 10600                 10605             


Pro Lys   Arg Glu Glu Glu Pro   Pro Ala Lys Val Thr   Glu Phe Arg 
    10610                 10615                 10620             


Lys Arg   Val Val Lys Glu Glu   Lys Val Ser Ile Glu   Ala Pro Lys 
    10625                 10630                 10635             


Arg Glu   Pro Gln Pro Ile Lys   Glu Val Thr Ile Met   Glu Glu Lys 
    10640                 10645                 10650             


Glu Arg   Ala Tyr Thr Leu Glu   Glu Glu Ala Val Ser   Val Gln Arg 
    10655                 10660                 10665             


Glu Glu   Glu Tyr Glu Glu Tyr   Glu Glu Tyr Asp Tyr   Lys Glu Phe 
    10670                 10675                 10680             


Glu Glu   Tyr Glu Pro Thr Glu   Glu Tyr Asp Gln Tyr   Glu Glu Tyr 
    10685                 10690                 10695             


Glu Glu   Arg Glu Tyr Glu Arg   Tyr Glu Glu His Glu   Glu Tyr Ile 
    10700                 10705                 10710             


Thr Glu   Pro Glu Lys Pro Ile   Pro Val Lys Pro Val   Pro Glu Glu 
    10715                 10720                 10725             


Pro Val   Pro Thr Lys Pro Lys   Ala Pro Pro Ala Lys   Val Leu Lys 
    10730                 10735                 10740             


Lys Ala   Val Pro Glu Glu Lys   Val Pro Val Pro Ile   Pro Lys Lys 
    10745                 10750                 10755             


Leu Lys   Pro Pro Pro Pro Lys   Val Pro Glu Glu Pro   Lys Lys Val 
    10760                 10765                 10770             


Phe Glu   Glu Lys Ile Arg Ile   Ser Ile Thr Lys Arg   Glu Lys Glu 
    10775                 10780                 10785             


Gln Val   Thr Glu Pro Ala Ala   Lys Val Pro Met Lys   Pro Lys Arg 
    10790                 10795                 10800             


Val Val   Ala Glu Glu Lys Val   Pro Val Pro Arg Lys   Glu Val Ala 
    10805                 10810                 10815             


Pro Pro   Val Arg Val Pro Glu   Val Pro Lys Glu Leu   Glu Pro Glu 
    10820                 10825                 10830             


Glu Val   Ala Phe Glu Glu Glu   Val Val Thr His Val   Glu Glu Tyr 
    10835                 10840                 10845             


Leu Val   Glu Glu Glu Glu Glu   Tyr Ile His Glu Glu   Glu Glu Phe 
    10850                 10855                 10860             


Ile Thr   Glu Glu Glu Val Val   Pro Val Ile Pro Val   Lys Val Pro 
    10865                 10870                 10875             


Glu Val   Pro Arg Lys Pro Val   Pro Glu Glu Lys Lys   Pro Val Pro 
    10880                 10885                 10890             


Val Pro   Lys Lys Lys Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val 
    10895                 10900                 10905             


Pro Lys   Lys Pro Glu Glu Lys   Val Pro Val Leu Ile   Pro Lys Lys 
    10910                 10915                 10920             


Glu Lys   Pro Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10925                 10930                 10935             


Val Pro   Glu Glu Lys Val Pro   Val Pro Val Pro Lys   Lys Val Glu 
    10940                 10945                 10950             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Pro Val Pro 
    10955                 10960                 10965             


Glu Lys   Lys Val Pro Val Pro   Ala Pro Lys Lys Val   Glu Ala Pro 
    10970                 10975                 10980             


Pro Ala   Lys Val Pro Glu Val   Pro Lys Lys Leu Ile   Pro Glu Glu 
    10985                 10990                 10995             


Lys Lys   Pro Thr Pro Val Pro   Lys Lys Val Glu Ala   Pro Pro Pro 
    11000                 11005                 11010             


Lys Val   Pro Lys Lys Arg Glu   Pro Val Pro Val Pro   Val Ala Leu 
    11015                 11020                 11025             


Pro Gln   Glu Glu Glu Val Leu   Phe Glu Glu Glu Ile   Val Pro Glu 
    11030                 11035                 11040             


Glu Glu   Val Leu Pro Glu Glu   Glu Glu Val Leu Pro   Glu Glu Glu 
    11045                 11050                 11055             


Glu Val   Leu Pro Glu Glu Glu   Glu Val Leu Pro Glu   Glu Glu Glu 
    11060                 11065                 11070             


Ile Pro   Pro Glu Glu Glu Glu   Val Pro Pro Glu Glu   Glu Tyr Val 
    11075                 11080                 11085             


Pro Glu   Glu Glu Glu Phe Val   Pro Glu Glu Glu Val   Leu Pro Glu 
    11090                 11095                 11100             


Val Lys   Pro Lys Val Pro Val   Pro Ala Pro Val Pro   Glu Ile Lys 
    11105                 11110                 11115             


Lys Lys   Val Thr Glu Lys Lys   Val Val Ile Pro Lys   Lys Glu Glu 
    11120                 11125                 11130             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Val Glu Glu 
    11135                 11140                 11145             


Lys Arg   Ile Ile Leu Pro Lys   Glu Glu Glu Val Leu   Pro Val Glu 
    11150                 11155                 11160             


Val Thr   Glu Glu Pro Glu Glu   Glu Pro Ile Ser Glu   Glu Glu Ile 
    11165                 11170                 11175             


Pro Glu   Glu Pro Pro Ser Ile   Glu Glu Val Glu Glu   Val Ala Pro 
    11180                 11185                 11190             


Pro Arg   Val Pro Glu Val Ile   Lys Lys Ala Val Pro   Glu Ala Pro 
    11195                 11200                 11205             


Thr Pro   Val Pro Lys Lys Val   Glu Ala Pro Pro Ala   Lys Val Ser 
    11210                 11215                 11220             


Lys Lys   Ile Pro Glu Glu Lys   Val Pro Val Pro Val   Gln Lys Lys 
    11225                 11230                 11235             


Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val Pro Lys   Lys Val Pro 
    11240                 11245                 11250             


Glu Lys   Lys Val Leu Val Pro   Lys Lys Glu Ala Val   Pro Pro Ala 
    11255                 11260                 11265             


Lys Gly   Arg Thr Val Leu Glu   Glu Lys Val Ser Val   Ala Phe Arg 
    11270                 11275                 11280             


Gln Glu   Val Val Val Lys Glu   Arg Leu Glu Leu Glu   Val Val Glu 
    11285                 11290                 11295             


Ala Glu   Val Glu Glu Ile Pro   Glu Glu Glu Glu Phe   His Glu Val 
    11300                 11305                 11310             


Glu Glu   Tyr Phe Glu Glu Gly   Glu Phe His Glu Val   Glu Glu Phe 
    11315                 11320                 11325             


Ile Lys   Leu Glu Gln His Arg   Val Glu Glu Glu His   Arg Val Glu 
    11330                 11335                 11340             


Lys Val   His Arg Val Ile Glu   Val Phe Glu Ala Glu   Glu Val Glu 
    11345                 11350                 11355             


Val Phe   Glu Lys Pro Lys Ala   Pro Pro Lys Gly Pro   Glu Ile Ser 
    11360                 11365                 11370             


Glu Lys   Ile Ile Pro Pro Lys   Lys Pro Pro Thr Lys   Val Val Pro 
    11375                 11380                 11385             


Arg Lys   Glu Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Ile 
    11390                 11395                 11400             


Val Val   Glu Glu Lys Val Arg   Val Pro Glu Glu Pro   Arg Val Pro 
    11405                 11410                 11415             


Pro Thr   Lys Val Pro Asp Val   Leu Pro Pro Lys Glu   Val Val Pro 
    11420                 11425                 11430             


Glu Lys   Lys Val Pro Val Pro   Pro Ala Lys Lys Pro   Glu Ala Pro 
    11435                 11440                 11445             


Pro Pro   Lys Val Pro Glu Ala   Pro Lys Glu Val Val   Pro Glu Lys 
    11450                 11455                 11460             


Lys Val   Pro Val Pro Pro Pro   Lys Lys Pro Glu Val   Pro Pro Thr 
    11465                 11470                 11475             


Lys Val   Pro Glu Val Pro Lys   Ala Ala Val Pro Glu   Lys Lys Val 
    11480                 11485                 11490             


Pro Glu   Ala Ile Pro Pro Lys   Pro Glu Ser Pro Pro   Pro Glu Val 
    11495                 11500                 11505             


Pro Glu   Ala Pro Lys Glu Val   Val Pro Glu Lys Lys   Val Pro Ala 
    11510                 11515                 11520             


Ala Pro   Pro Lys Lys Pro Glu   Val Thr Pro Val Lys   Val Pro Glu 
    11525                 11530                 11535             


Ala Pro   Lys Glu Val Val Pro   Glu Lys Lys Val Pro   Val Pro Pro 
    11540                 11545                 11550             


Pro Lys   Lys Pro Glu Val Pro   Pro Thr Lys Val Pro   Glu Val Pro 
    11555                 11560                 11565             


Lys Val   Ala Val Pro Glu Lys   Lys Val Pro Glu Ala   Ile Pro Pro 
    11570                 11575                 11580             


Lys Pro   Glu Ser Pro Pro Pro   Glu Val Phe Glu Glu   Pro Glu Glu 
    11585                 11590                 11595             


Val Ala   Leu Glu Glu Pro Pro   Ala Glu Val Val Glu   Glu Pro Glu 
    11600                 11605                 11610             


Pro Ala   Ala Pro Pro Gln Val   Thr Val Pro Pro Lys   Lys Pro Val 
    11615                 11620                 11625             


Pro Glu   Lys Lys Ala Pro Ala   Val Val Ala Lys Lys   Pro Glu Leu 
    11630                 11635                 11640             


Pro Pro   Val Lys Val Pro Glu   Val Pro Lys Glu Val   Val Pro Glu 
    11645                 11650                 11655             


Lys Lys   Val Pro Leu Val Val   Pro Lys Lys Pro Glu   Ala Pro Pro 
    11660                 11665                 11670             


Ala Lys   Val Pro Glu Val Pro   Lys Glu Val Val Pro   Glu Lys Lys 
    11675                 11680                 11685             


Val Ala   Val Pro Lys Lys Pro   Glu Val Pro Pro Ala   Lys Val Pro 
    11690                 11695                 11700             


Glu Val   Pro Lys Lys Pro Val   Leu Glu Glu Lys Pro   Ala Val Pro 
    11705                 11710                 11715             


Val Pro   Glu Arg Ala Glu Ser   Pro Pro Pro Glu Val   Tyr Glu Glu 
    11720                 11725                 11730             


Pro Glu   Glu Ile Ala Pro Glu   Glu Glu Ile Ala Pro   Glu Glu Glu 
    11735                 11740                 11745             


Lys Pro   Val Pro Val Ala Glu   Glu Glu Glu Pro Glu   Val Pro Pro 
    11750                 11755                 11760             


Pro Ala   Val Pro Glu Glu Pro   Lys Lys Ile Ile Pro   Glu Lys Lys 
    11765                 11770                 11775             


Val Pro   Val Ile Lys Lys Pro   Glu Ala Pro Pro Pro   Lys Glu Pro 
    11780                 11785                 11790             


Glu Pro   Glu Lys Val Ile Glu   Lys Pro Lys Leu Lys   Pro Arg Pro 
    11795                 11800                 11805             


Pro Pro   Pro Pro Pro Ala Pro   Pro Lys Glu Asp Val   Lys Glu Lys 
    11810                 11815                 11820             


Ile Phe   Gln Leu Lys Ala Ile   Pro Lys Lys Lys Val   Pro Glu Lys 
    11825                 11830                 11835             


Pro Gln   Val Pro Glu Lys Val   Glu Leu Thr Pro Leu   Lys Val Pro 
    11840                 11845                 11850             


Gly Gly   Glu Lys Lys Val Arg   Lys Leu Leu Pro Glu   Arg Lys Pro 
    11855                 11860                 11865             


Glu Pro   Lys Glu Glu Val Val   Leu Lys Ser Val Leu   Arg Lys Arg 
    11870                 11875                 11880             


Pro Glu   Glu Glu Glu Pro Lys   Val Glu Pro Lys Lys   Leu Glu Lys 
    11885                 11890                 11895             


Val Lys   Lys Pro Ala Val Pro   Glu Pro Pro Pro Pro   Lys Pro Val 
    11900                 11905                 11910             


Glu Glu   Val Glu Val Pro Thr   Val Thr Lys Arg Glu   Arg Lys Ile 
    11915                 11920                 11925             


Pro Glu   Pro Thr Lys Val Pro   Glu Ile Lys Pro Ala   Ile Pro Leu 
    11930                 11935                 11940             


Pro Ala   Pro Glu Pro Lys Pro   Lys Pro Glu Ala Glu   Val Lys Thr 
    11945                 11950                 11955             


Ile Lys   Pro Pro Pro Val Glu   Pro Glu Pro Thr Pro   Ile Ala Ala 
    11960                 11965                 11970             


Pro Val   Thr Val Pro Val Val   Gly Lys Lys Ala Glu   Ala Lys Ala 
    11975                 11980                 11985             


Pro Lys   Glu Glu Ala Ala Lys   Pro Lys Gly Pro Ile   Lys Gly Val 
    11990                 11995                 12000             


Pro Lys   Lys Thr Pro Ser Pro   Ile Glu Ala Glu Arg   Arg Lys Leu 
    12005                 12010                 12015             


Arg Pro   Gly Ser Gly Gly Glu   Lys Pro Pro Asp Glu   Ala Pro Phe 
    12020                 12025                 12030             


Thr Tyr   Gln Leu Lys Ala Val   Pro Leu Lys Phe Val   Lys Glu Ile 
    12035                 12040                 12045             


Lys Asp   Ile Ile Leu Thr Glu   Ser Glu Phe Val Gly   Ser Ser Ala 
    12050                 12055                 12060             


Ile Phe   Glu Cys Leu Val Ser   Pro Ser Thr Ala Ile   Thr Thr Trp 
    12065                 12070                 12075             


Met Lys   Asp Gly Ser Asn Ile   Arg Glu Ser Pro Lys   His Arg Phe 
    12080                 12085                 12090             


Ile Ala   Asp Gly Lys Asp Arg   Lys Leu His Ile Ile   Asp Val Gln 
    12095                 12100                 12105             


Leu Ser   Asp Ala Gly Glu Tyr   Thr Cys Val Leu Arg   Leu Gly Asn 
    12110                 12115                 12120             


Lys Glu   Lys Thr Ser Thr Ala   Lys Leu Val Val Glu   Glu Leu Pro 
    12125                 12130                 12135             


Val Arg   Phe Val Lys Thr Leu   Glu Glu Glu Val Thr   Val Val Lys 
    12140                 12145                 12150             


Gly Gln   Pro Leu Tyr Leu Ser   Cys Glu Leu Asn Lys   Glu Arg Asp 
    12155                 12160                 12165             


Val Val   Trp Arg Lys Asp Gly   Lys Ile Val Val Glu   Lys Pro Gly 
    12170                 12175                 12180             


Arg Ile   Val Pro Gly Val Ile   Gly Leu Met Arg Ala   Leu Thr Ile 
    12185                 12190                 12195             


Asn Asp   Ala Asp Asp Thr Asp   Ala Gly Thr Tyr Thr   Val Thr Val 
    12200                 12205                 12210             


Glu Asn   Ala Asn Asn Leu Glu   Cys Ser Ser Cys Val   Lys Val Val 
    12215                 12220                 12225             


Glu Val   Ile Arg Asp Trp Leu   Val Lys Pro Ile Arg   Asp Gln His 
    12230                 12235                 12240             


Val Lys   Pro Lys Gly Thr Ala   Ile Phe Ala Cys Asp   Ile Ala Lys 
    12245                 12250                 12255             


Asp Thr   Pro Asn Ile Lys Trp   Phe Lys Gly Tyr Asp   Glu Ile Pro 
    12260                 12265                 12270             


Ala Glu   Pro Asn Asp Lys Thr   Glu Ile Leu Arg Asp   Gly Asn His 
    12275                 12280                 12285             


Leu Tyr   Leu Lys Ile Lys Asn   Ala Met Pro Glu Asp   Ile Ala Glu 
    12290                 12295                 12300             


Tyr Ala   Val Glu Ile Glu Gly   Lys Arg Tyr Pro Ala   Lys Leu Thr 
    12305                 12310                 12315             


Leu Gly   Glu Arg Glu Val Glu   Leu Leu Lys Pro Ile   Glu Asp Val 
    12320                 12325                 12330             


Thr Ile   Tyr Glu Lys Glu Ser   Ala Ser Phe Asp Ala   Glu Ile Ser 
    12335                 12340                 12345             


Glu Ala   Asp Ile Pro Gly Gln   Trp Lys Leu Lys Gly   Glu Leu Leu 
    12350                 12355                 12360             


Arg Pro   Ser Pro Thr Cys Glu   Ile Lys Ala Glu Gly   Gly Lys Arg 
    12365                 12370                 12375             


Phe Leu   Thr Leu Arg Lys Val   Lys Leu Asp Gln Ala   Gly Glu Val 
    12380                 12385                 12390             


Leu Tyr   Gln Ala Leu Asn Ala   Ile Thr Thr Ala Ile   Leu Thr Val 
    12395                 12400                 12405             


Lys Glu   Ile Glu Leu Asp Phe   Ala Val Pro Leu Lys   Asp Val Thr 
    12410                 12415                 12420             


Val Pro   Glu Arg Arg Gln Ala   Arg Phe Glu Cys Val   Leu Thr Arg 
    12425                 12430                 12435             


Glu Ala   Asn Val Ile Trp Ser   Lys Gly Pro Asp Ile   Ile Lys Ser 
    12440                 12445                 12450             


Ser Asp   Lys Phe Asp Ile Ile   Ala Asp Gly Lys Lys   His Ile Leu 
    12455                 12460                 12465             


Val Ile   Asn Asp Ser Gln Phe   Asp Asp Glu Gly Val   Tyr Thr Ala 
    12470                 12475                 12480             


Glu Val   Glu Gly Lys Lys Thr   Ser Ala Arg Leu Phe   Val Thr Gly 
    12485                 12490                 12495             


Ile Arg   Leu Lys Phe Met Ser   Pro Leu Glu Asp Gln   Thr Val Lys 
    12500                 12505                 12510             


Glu Gly   Glu Thr Ala Thr Phe   Val Cys Glu Leu Ser   His Glu Lys 
    12515                 12520                 12525             


Met His   Val Val Trp Phe Lys   Asn Asp Ala Lys Leu   His Thr Ser 
    12530                 12535                 12540             


Arg Thr   Val Leu Ile Ser Ser   Glu Gly Lys Thr His   Lys Leu Glu 
    12545                 12550                 12555             


Met Lys   Glu Val Thr Leu Asp   Asp Ile Ser Gln Ile   Lys Ala Gln 
    12560                 12565                 12570             


Val Lys   Glu Leu Ser Ser Thr   Ala Gln Leu Lys Val   Leu Glu Ala 
    12575                 12580                 12585             


Asp Pro   Tyr Phe Thr Val Lys   Leu His Asp Lys Thr   Ala Val Glu 
    12590                 12595                 12600             


Lys Asp   Glu Ile Thr Leu Lys   Cys Glu Val Ser Lys   Asp Val Pro 
    12605                 12610                 12615             


Val Lys   Trp Phe Lys Asp Gly   Glu Glu Ile Val Pro   Ser Pro Lys 
    12620                 12625                 12630             


Tyr Ser   Ile Lys Ala Asp Gly   Leu Arg Arg Ile Leu   Lys Ile Lys 
    12635                 12640                 12645             


Lys Ala   Asp Leu Lys Asp Lys   Gly Glu Tyr Val Cys   Asp Cys Gly 
    12650                 12655                 12660             


Thr Asp   Lys Thr Lys Ala Asn   Val Thr Val Glu Ala   Arg Leu Ile 
    12665                 12670                 12675             


Lys Val   Glu Lys Pro Leu Tyr   Gly Val Glu Val Phe   Val Gly Glu 
    12680                 12685                 12690             


Thr Ala   His Phe Glu Ile Glu   Leu Ser Glu Pro Asp   Val His Gly 
    12695                 12700                 12705             


Gln Trp   Lys Leu Lys Gly Gln   Pro Leu Thr Ala Ser   Pro Asp Cys 
    12710                 12715                 12720             


Glu Ile   Ile Glu Asp Gly Lys   Lys His Ile Leu Ile   Leu His Asn 
    12725                 12730                 12735             


Cys Gln   Leu Gly Met Thr Gly   Glu Val Ser Phe Gln   Ala Ala Asn 
    12740                 12745                 12750             


Ala Lys   Ser Ala Ala Asn Leu   Lys Val Lys Glu Leu   Pro Leu Ile 
    12755                 12760                 12765             


Phe Ile   Thr Pro Leu Ser Asp   Val Lys Val Phe Glu   Lys Asp Glu 
    12770                 12775                 12780             


Ala Lys   Phe Glu Cys Glu Val   Ser Arg Glu Pro Lys   Thr Phe Arg 
    12785                 12790                 12795             


Trp Leu   Lys Gly Thr Gln Glu   Ile Thr Gly Asp Asp   Arg Phe Glu 
    12800                 12805                 12810             


Leu Ile   Lys Asp Gly Thr Lys   His Ser Met Val Ile   Lys Ser Ala 
    12815                 12820                 12825             


Ala Phe   Glu Asp Glu Ala Lys   Tyr Met Phe Glu Ala   Glu Asp Lys 
    12830                 12835                 12840             


His Thr   Ser Gly Lys Leu Ile   Ile Glu Gly Ile Arg   Leu Lys Phe 
    12845                 12850                 12855             


Leu Thr   Pro Leu Lys Asp Val   Thr Ala Lys Glu Lys   Glu Ser Ala 
    12860                 12865                 12870             


Val Phe   Thr Val Glu Leu Ser   His Asp Asn Ile Arg   Val Lys Trp 
    12875                 12880                 12885             


Phe Lys   Asn Asp Gln Arg Leu   His Thr Thr Arg Ser   Val Ser Met 
    12890                 12895                 12900             


Gln Asp   Glu Gly Lys Thr His   Ser Ile Thr Phe Lys   Asp Leu Ser 
    12905                 12910                 12915             


Ile Asp   Asp Thr Ser Gln Ile   Arg Val Glu Ala Met   Gly Met Ser 
    12920                 12925                 12930             


Ser Glu   Ala Lys Leu Thr Val   Leu Glu Gly Asp Pro   Tyr Phe Thr 
    12935                 12940                 12945             


Gly Lys   Leu Gln Asp Tyr Thr   Gly Val Glu Lys Asp   Glu Val Ile 
    12950                 12955                 12960             


Leu Gln   Cys Glu Ile Ser Lys   Ala Asp Ala Pro Val   Lys Trp Phe 
    12965                 12970                 12975             


Lys Asp   Gly Lys Glu Ile Lys   Pro Ser Lys Asn Ala   Val Ile Lys 
    12980                 12985                 12990             


Ala Asp   Gly Lys Lys Arg Met   Leu Ile Leu Lys Lys   Ala Leu Lys 
    12995                 13000                 13005             


Ser Asp   Ile Gly Gln Tyr Thr   Cys Asp Cys Gly Thr   Asp Lys Thr 
    13010                 13015                 13020             


Ser Gly   Lys Leu Asp Ile Glu   Asp Arg Glu Ile Lys   Leu Val Arg 
    13025                 13030                 13035             


Pro Leu   His Ser Val Glu Val   Met Glu Thr Glu Thr   Ala Arg Phe 
    13040                 13045                 13050             


Glu Thr   Glu Ile Ser Glu Asp   Asp Ile His Ala Asn   Trp Lys Leu 
    13055                 13060                 13065             


Lys Gly   Glu Ala Leu Leu Gln   Thr Pro Asp Cys Glu   Ile Lys Glu 
    13070                 13075                 13080             


Glu Gly   Lys Ile His Ser Leu   Val Leu His Asn Cys   Arg Leu Asp 
    13085                 13090                 13095             


Gln Thr   Gly Gly Val Asp Phe   Gln Ala Ala Asn Val   Lys Ser Ser 
    13100                 13105                 13110             


Ala His   Leu Arg Val Lys Pro   Arg Val Ile Gly Leu   Leu Arg Pro 
    13115                 13120                 13125             


Leu Lys   Asp Val Thr Val Thr   Ala Gly Glu Thr Ala   Thr Phe Asp 
    13130                 13135                 13140             


Cys Glu   Leu Ser Tyr Glu Asp   Ile Pro Val Glu Trp   Tyr Leu Lys 
    13145                 13150                 13155             


Gly Lys   Lys Leu Glu Pro Ser   Asp Lys Val Val Pro   Arg Ser Glu 
    13160                 13165                 13170             


Gly Lys   Val His Thr Leu Thr   Leu Arg Asp Val Lys   Leu Glu Asp 
    13175                 13180                 13185             


Ala Gly   Glu Val Gln Leu Thr   Ala Lys Asp Phe Lys   Thr His Ala 
    13190                 13195                 13200             


Asn Leu   Phe Val Lys Glu Pro   Pro Val Glu Phe Thr   Lys Pro Leu 
    13205                 13210                 13215             


Glu Asp   Gln Thr Val Glu Glu   Gly Ala Thr Ala Val   Leu Glu Cys 
    13220                 13225                 13230             


Glu Val   Ser Arg Glu Asn Ala   Lys Val Lys Trp Phe   Lys Asn Gly 
    13235                 13240                 13245             


Thr Glu   Ile Leu Lys Ser Lys   Lys Tyr Glu Ile Val   Ala Asp Gly 
    13250                 13255                 13260             


Arg Val   Arg Lys Leu Val Ile   His Asp Cys Thr Pro   Glu Asp Ile 
    13265                 13270                 13275             


Lys Thr   Tyr Thr Cys Asp Ala   Lys Asp Phe Lys Thr   Ser Cys Asn 
    13280                 13285                 13290             


Leu Asn   Val Val Pro Pro His   Val Glu Phe Leu Arg   Pro Leu Thr 
    13295                 13300                 13305             


Asp Leu   Gln Val Arg Glu Lys   Glu Met Ala Arg Phe   Glu Cys Glu 
    13310                 13315                 13320             


Leu Ser   Arg Glu Asn Ala Lys   Val Lys Trp Phe Lys   Asp Gly Ala 
    13325                 13330                 13335             


Glu Ile   Lys Lys Gly Lys Lys   Tyr Asp Ile Ile Ser   Lys Gly Ala 
    13340                 13345                 13350             


Val Arg   Ile Leu Val Ile Asn   Lys Cys Leu Leu Asp   Asp Glu Ala 
    13355                 13360                 13365             


Glu Tyr   Ser Cys Glu Val Arg   Thr Ala Arg Thr Ser   Gly Met Leu 
    13370                 13375                 13380             


Thr Val   Leu Glu Glu Glu Ala   Val Phe Thr Lys Asn   Leu Ala Asn 
    13385                 13390                 13395             


Ile Glu   Val Ser Glu Thr Asp   Thr Ile Lys Leu Val   Cys Glu Val 
    13400                 13405                 13410             


Ser Lys   Pro Gly Ala Glu Val   Ile Trp Tyr Lys Gly   Asp Glu Glu 
    13415                 13420                 13425             


Ile Ile   Glu Thr Gly Arg Tyr   Glu Ile Leu Thr Glu   Gly Arg Lys 
    13430                 13435                 13440             


Arg Ile   Leu Val Ile Gln Asn   Ala His Leu Glu Asp   Ala Gly Asn 
    13445                 13450                 13455             


Tyr Asn   Cys Arg Leu Pro Ser   Ser Arg Thr Asp Gly   Lys Val Lys 
    13460                 13465                 13470             


Val His   Glu Leu Ala Ala Glu   Phe Ile Ser Lys Pro   Gln Asn Leu 
    13475                 13480                 13485             


Glu Ile   Leu Glu Gly Glu Lys   Ala Glu Phe Val Cys   Ser Ile Ser 
    13490                 13495                 13500             


Lys Glu   Ser Phe Pro Val Gln   Trp Lys Arg Asp Asp   Lys Thr Leu 
    13505                 13510                 13515             


Glu Ser   Gly Asp Lys Tyr Asp   Val Ile Ala Asp Gly   Lys Lys Arg 
    13520                 13525                 13530             


Val Leu   Val Val Lys Asp Ala   Thr Leu Gln Asp Met   Gly Thr Tyr 
    13535                 13540                 13545             


Val Val   Met Val Gly Ala Ala   Arg Ala Ala Ala His   Leu Thr Val 
    13550                 13555                 13560             


Ile Glu   Lys Leu Arg Ile Val   Val Pro Leu Lys Asp   Thr Arg Val 
    13565                 13570                 13575             


Lys Glu   Gln Gln Glu Val Val   Phe Asn Cys Glu Val   Asn Thr Glu 
    13580                 13585                 13590             


Gly Ala   Lys Ala Lys Trp Phe   Arg Asn Glu Glu Ala   Ile Phe Asp 
    13595                 13600                 13605             


Ser Ser   Lys Tyr Ile Ile Leu   Gln Lys Asp Leu Val   Tyr Thr Leu 
    13610                 13615                 13620             


Arg Ile   Arg Asp Ala His Leu   Asp Asp Gln Ala Asn   Tyr Asn Val 
    13625                 13630                 13635             


Ser Leu   Thr Asn His Arg Gly   Glu Asn Val Lys Ser   Ala Ala Asn 
    13640                 13645                 13650             


Leu Ile   Val Glu Glu Glu Asp   Leu Arg Ile Val Glu   Pro Leu Lys 
    13655                 13660                 13665             


Asp Ile   Glu Thr Met Glu Lys   Lys Ser Val Thr Phe   Trp Cys Lys 
    13670                 13675                 13680             


Val Asn   Arg Leu Asn Val Thr   Leu Lys Trp Thr Lys   Asn Gly Glu 
    13685                 13690                 13695             


Glu Val   Pro Phe Asp Asn Arg   Val Ser Tyr Arg Val   Asp Lys Tyr 
    13700                 13705                 13710             


Lys His   Met Leu Thr Ile Lys   Asp Cys Gly Phe Pro   Asp Glu Gly 
    13715                 13720                 13725             


Glu Tyr   Ile Val Thr Ala Gly   Gln Asp Lys Ser Val   Ala Glu Leu 
    13730                 13735                 13740             


Leu Ile   Ile Glu Ala Pro Thr   Glu Phe Val Glu His   Leu Glu Asp 
    13745                 13750                 13755             


Gln Thr   Val Thr Glu Phe Asp   Asp Ala Val Phe Ser   Cys Gln Leu 
    13760                 13765                 13770             


Ser Arg   Glu Lys Ala Asn Val   Lys Trp Tyr Arg Asn   Gly Arg Glu 
    13775                 13780                 13785             


Ile Lys   Glu Gly Lys Lys Tyr   Lys Phe Glu Lys Asp   Gly Ser Ile 
    13790                 13795                 13800             


His Arg   Leu Ile Ile Lys Asp   Cys Arg Leu Asp Asp   Glu Cys Glu 
    13805                 13810                 13815             


Tyr Ala   Cys Gly Val Glu Asp   Arg Lys Ser Arg Ala   Arg Leu Phe 
    13820                 13825                 13830             


Val Glu   Glu Ile Pro Val Glu   Ile Ile Arg Pro Pro   Gln Asp Ile 
    13835                 13840                 13845             


Leu Glu   Ala Pro Gly Ala Asp   Val Val Phe Leu Ala   Glu Leu Asn 
    13850                 13855                 13860             


Lys Asp   Lys Val Glu Val Gln   Trp Leu Arg Asn Asn   Met Val Val 
    13865                 13870                 13875             


Val Gln   Gly Asp Lys His Gln   Met Met Ser Glu Gly   Lys Ile His 
    13880                 13885                 13890             


Arg Leu   Gln Ile Cys Asp Ile   Lys Pro Arg Asp Gln   Gly Glu Tyr 
    13895                 13900                 13905             


Arg Phe   Ile Ala Lys Asp Lys   Glu Ala Arg Ala Lys   Leu Glu Leu 
    13910                 13915                 13920             


Ala Ala   Ala Pro Lys Ile Lys   Thr Ala Asp Gln Asp   Leu Val Val 
    13925                 13930                 13935             


Asp Val   Gly Lys Pro Leu Thr   Met Val Val Pro Tyr   Asp Ala Tyr 
    13940                 13945                 13950             


Pro Lys   Ala Glu Ala Glu Trp   Phe Lys Glu Asn Glu   Pro Leu Ser 
    13955                 13960                 13965             


Thr Lys   Thr Ile Asp Thr Thr   Ala Glu Gln Thr Ser   Phe Arg Ile 
    13970                 13975                 13980             


Leu Glu   Ala Lys Lys Gly Asp   Lys Gly Arg Tyr Lys   Ile Val Leu 
    13985                 13990                 13995             


Gln Asn   Lys His Gly Lys Ala   Glu Gly Phe Ile Asn   Leu Lys Val 
    14000                 14005                 14010             


Ile Asp   Val Pro Gly Pro Val   Arg Asn Leu Glu Val   Thr Glu Thr 
    14015                 14020                 14025             


Phe Asp   Gly Glu Val Ser Leu   Ala Trp Glu Glu Pro   Leu Thr Asp 
    14030                 14035                 14040             


Gly Gly   Ser Lys Ile Ile Gly   Tyr Val Val Glu Arg   Arg Asp Ile 
    14045                 14050                 14055             


Lys Arg   Lys Thr Trp Val Leu   Ala Thr Asp Arg Ala   Glu Ser Cys 
    14060                 14065                 14070             


Glu Phe   Thr Val Thr Gly Leu   Gln Lys Gly Gly Val   Glu Tyr Leu 
    14075                 14080                 14085             


Phe Arg   Val Ser Ala Arg Asn   Arg Val Gly Thr Gly   Glu Pro Val 
    14090                 14095                 14100             


Glu Thr   Asp Asn Pro Val Glu   Ala Arg Ser Lys Tyr   Asp Val Pro 
    14105                 14110                 14115             


Gly Pro   Pro Leu Asn Val Thr   Ile Thr Asp Val Asn   Arg Phe Gly 
    14120                 14125                 14130             


Val Ser   Leu Thr Trp Glu Pro   Pro Glu Tyr Asp Gly   Gly Ala Glu 
    14135                 14140                 14145             


Ile Thr   Asn Tyr Val Ile Glu   Leu Arg Asp Lys Thr   Ser Ile Arg 
    14150                 14155                 14160             


Trp Asp   Thr Ala Met Thr Val   Arg Ala Glu Asp Leu   Ser Ala Thr 
    14165                 14170                 14175             


Val Thr   Asp Val Val Glu Gly   Gln Glu Tyr Ser Phe   Arg Val Arg 
    14180                 14185                 14190             


Ala Gln   Asn Arg Ile Gly Val   Gly Lys Pro Ser Ala   Ala Thr Pro 
    14195                 14200                 14205             


Phe Val   Lys Val Ala Asp Pro   Ile Glu Arg Pro Ser   Pro Pro Val 
    14210                 14215                 14220             


Asn Leu   Thr Ser Ser Asp Gln   Thr Gln Ser Ser Val   Gln Leu Lys 
    14225                 14230                 14235             


Trp Glu   Pro Pro Leu Lys Asp   Gly Gly Ser Pro Ile   Leu Gly Tyr 
    14240                 14245                 14250             


Ile Ile   Glu Arg Cys Glu Glu   Gly Lys Asp Asn Trp   Ile Arg Cys 
    14255                 14260                 14265             


Asn Met   Lys Leu Val Pro Glu   Leu Thr Tyr Lys Val   Thr Gly Leu 
    14270                 14275                 14280             


Glu Lys   Gly Asn Lys Tyr Leu   Tyr Arg Val Ser Ala   Glu Asn Lys 
    14285                 14290                 14295             


Ala Gly   Val Ser Asp Pro Ser   Glu Ile Leu Gly Pro   Leu Thr Ala 
    14300                 14305                 14310             


Asp Asp   Ala Phe Val Glu Pro   Thr Met Asp Leu Ser   Ala Phe Lys 
    14315                 14320                 14325             


Asp Gly   Leu Glu Val Ile Val   Pro Asn Pro Ile Thr   Ile Leu Val 
    14330                 14335                 14340             


Pro Ser   Thr Gly Tyr Pro Arg   Pro Thr Ala Thr Trp   Cys Phe Gly 
    14345                 14350                 14355             


Asp Lys   Val Leu Glu Thr Gly   Asp Arg Val Lys Met   Lys Thr Leu 
    14360                 14365                 14370             


Ser Ala   Tyr Ala Glu Leu Val   Ile Ser Pro Ser Glu   Arg Ser Asp 
    14375                 14380                 14385             


Lys Gly   Ile Tyr Thr Leu Lys   Leu Glu Asn Arg Val   Lys Thr Ile 
    14390                 14395                 14400             


Ser Gly   Glu Ile Asp Val Asn   Val Ile Ala Arg Pro   Ser Ala Pro 
    14405                 14410                 14415             


Lys Glu   Leu Lys Phe Gly Asp   Ile Thr Lys Asp Ser   Val His Leu 
    14420                 14425                 14430             


Thr Trp   Glu Pro Pro Asp Asp   Asp Gly Gly Ser Pro   Leu Thr Gly 
    14435                 14440                 14445             


Tyr Val   Val Glu Lys Arg Glu   Val Ser Arg Lys Thr   Trp Thr Lys 
    14450                 14455                 14460             


Val Met   Asp Phe Val Thr Asp   Leu Glu Phe Thr Val   Pro Asp Leu 
    14465                 14470                 14475             


Val Gln   Gly Lys Glu Tyr Leu   Phe Lys Val Cys Ala   Arg Asn Lys 
    14480                 14485                 14490             


Cys Gly   Pro Gly Glu Pro Ala   Tyr Val Asp Glu Pro   Val Asn Met 
    14495                 14500                 14505             


Ser Thr   Pro Ala Thr Val Pro   Asp Pro Pro Glu Asn   Val Lys Trp 
    14510                 14515                 14520             


Arg Asp   Arg Thr Ala Asn Ser   Ile Phe Leu Thr Trp   Asp Pro Pro 
    14525                 14530                 14535             


Lys Asn   Asp Gly Gly Ser Arg   Ile Lys Gly Tyr Ile   Val Glu Arg 
    14540                 14545                 14550             


Cys Pro   Arg Gly Ser Asp Lys   Trp Val Ala Cys Gly   Glu Pro Val 
    14555                 14560                 14565             


Ala Glu   Thr Lys Met Glu Val   Thr Gly Leu Glu Glu   Gly Lys Trp 
    14570                 14575                 14580             


Tyr Ala   Tyr Arg Val Lys Ala   Leu Asn Arg Gln Gly   Ala Ser Lys 
    14585                 14590                 14595             


Pro Ser   Arg Pro Thr Glu Glu   Ile Gln Ala Val Asp   Thr Gln Glu 
    14600                 14605                 14610             


Ala Pro   Glu Ile Phe Leu Asp   Val Lys Leu Leu Ala   Gly Leu Thr 
    14615                 14620                 14625             


Val Lys   Ala Gly Thr Lys Ile   Glu Leu Pro Ala Thr   Val Thr Gly 
    14630                 14635                 14640             


Lys Pro   Glu Pro Lys Ile Thr   Trp Thr Lys Ala Asp   Met Ile Leu 
    14645                 14650                 14655             


Lys Gln   Asp Lys Arg Ile Thr   Ile Glu Asn Val Pro   Lys Lys Ser 
    14660                 14665                 14670             


Thr Val   Thr Ile Val Asp Ser   Lys Arg Ser Asp Thr   Gly Thr Tyr 
    14675                 14680                 14685             


Ile Ile   Glu Ala Val Asn Val   Cys Gly Arg Ala Thr   Ala Val Val 
    14690                 14695                 14700             


Glu Val   Asn Val Leu Asp Lys   Pro Gly Pro Pro Ala   Ala Phe Asp 
    14705                 14710                 14715             


Ile Thr   Asp Val Thr Asn Glu   Ser Cys Leu Leu Thr   Trp Asn Pro 
    14720                 14725                 14730             


Pro Arg   Asp Asp Gly Gly Ser   Lys Ile Thr Asn Tyr   Val Val Glu 
    14735                 14740                 14745             


Arg Arg   Ala Thr Asp Ser Glu   Val Trp His Lys Leu   Ser Ser Thr 
    14750                 14755                 14760             


Val Lys   Asp Thr Asn Phe Lys   Ala Thr Lys Leu Ile   Pro Asn Lys 
    14765                 14770                 14775             


Glu Tyr   Ile Phe Arg Val Ala   Ala Glu Asn Met Tyr   Gly Val Gly 
    14780                 14785                 14790             


Glu Pro   Val Gln Ala Ser Pro   Ile Thr Ala Lys Tyr   Gln Phe Asp 
    14795                 14800                 14805             


Pro Pro   Gly Pro Pro Thr Arg   Leu Glu Pro Ser Asp   Ile Thr Lys 
    14810                 14815                 14820             


Asp Ala   Val Thr Leu Thr Trp   Cys Glu Pro Asp Asp   Asp Gly Gly 
    14825                 14830                 14835             


Ser Pro   Ile Thr Gly Tyr Trp   Val Glu Arg Leu Asp   Pro Asp Thr 
    14840                 14845                 14850             


Asp Lys   Trp Val Arg Cys Asn   Lys Met Pro Val Lys   Asp Thr Thr 
    14855                 14860                 14865             


Tyr Arg   Val Lys Gly Leu Thr   Asn Lys Lys Lys Tyr   Arg Phe Arg 
    14870                 14875                 14880             


Val Leu   Ala Glu Asn Leu Ala   Gly Pro Gly Lys Pro   Ser Lys Ser 
    14885                 14890                 14895             


Thr Glu   Pro Ile Leu Ile Lys   Asp Pro Ile Asp Pro   Pro Trp Pro 
    14900                 14905                 14910             


Pro Gly   Lys Pro Thr Val Lys   Asp Val Gly Lys Thr   Ser Val Arg 
    14915                 14920                 14925             


Leu Asn   Trp Thr Lys Pro Glu   His Asp Gly Gly Ala   Lys Ile Glu 
    14930                 14935                 14940             


Ser Tyr   Val Ile Glu Met Leu   Lys Thr Gly Thr Asp   Glu Trp Val 
    14945                 14950                 14955             


Arg Val   Ala Glu Gly Val Pro   Thr Thr Gln His Leu   Leu Pro Gly 
    14960                 14965                 14970             


Leu Met   Glu Gly Gln Glu Tyr   Ser Phe Arg Val Arg   Ala Val Asn 
    14975                 14980                 14985             


Lys Ala   Gly Glu Ser Glu Pro   Ser Glu Pro Ser Asp   Pro Val Leu 
    14990                 14995                 15000             


Cys Arg   Glu Lys Leu Tyr Pro   Pro Ser Pro Pro Arg   Trp Leu Glu 
    15005                 15010                 15015             


Val Ile   Asn Ile Thr Lys Asn   Thr Ala Asp Leu Lys   Trp Thr Val 
    15020                 15025                 15030             


Pro Glu   Lys Asp Gly Gly Ser   Pro Ile Thr Asn Tyr   Ile Val Glu 
    15035                 15040                 15045             


Lys Arg   Asp Val Arg Arg Lys   Gly Trp Gln Thr Val   Asp Thr Thr 
    15050                 15055                 15060             


Val Lys   Asp Thr Lys Cys Thr   Val Thr Pro Leu Thr   Glu Gly Ser 
    15065                 15070                 15075             


Leu Tyr   Val Phe Arg Val Ala   Ala Glu Asn Ala Ile   Gly Gln Ser 
    15080                 15085                 15090             


Asp Tyr   Thr Glu Ile Glu Asp   Ser Val Leu Ala Lys   Asp Thr Phe 
    15095                 15100                 15105             


Thr Thr   Pro Gly Pro Pro Tyr   Ala Leu Ala Val Val   Asp Val Thr 
    15110                 15115                 15120             


Lys Arg   His Val Asp Leu Lys   Trp Glu Pro Pro Lys   Asn Asp Gly 
    15125                 15130                 15135             


Gly Arg   Pro Ile Gln Arg Tyr   Val Ile Glu Lys Lys   Glu Arg Leu 
    15140                 15145                 15150             


Gly Thr   Arg Trp Val Lys Ala   Gly Lys Thr Ala Gly   Pro Asp Cys 
    15155                 15160                 15165             


Asn Phe   Arg Val Thr Asp Val   Ile Glu Gly Thr Glu   Val Gln Phe 
    15170                 15175                 15180             


Gln Val   Arg Ala Glu Asn Glu   Ala Gly Val Gly His   Pro Ser Glu 
    15185                 15190                 15195             


Pro Thr   Glu Ile Leu Ser Ile   Glu Asp Pro Thr Ser   Pro Pro Ser 
    15200                 15205                 15210             


Pro Pro   Leu Asp Leu His Val   Thr Asp Ala Gly Arg   Lys His Ile 
    15215                 15220                 15225             


Ala Ile   Ala Trp Lys Pro Pro   Glu Lys Asn Gly Gly   Ser Pro Ile 
    15230                 15235                 15240             


Ile Gly   Tyr His Val Glu Met   Cys Pro Val Gly Thr   Glu Lys Trp 
    15245                 15250                 15255             


Met Arg   Val Asn Ser Arg Pro   Ile Lys Asp Leu Lys   Phe Lys Val 
    15260                 15265                 15270             


Glu Glu   Gly Val Val Pro Asp   Lys Glu Tyr Val Leu   Arg Val Arg 
    15275                 15280                 15285             


Ala Val   Asn Ala Ile Gly Val   Ser Glu Pro Ser Glu   Ile Ser Glu 
    15290                 15295                 15300             


Asn Val   Val Ala Lys Asp Pro   Asp Cys Lys Pro Thr   Ile Asp Leu 
    15305                 15310                 15315             


Glu Thr   His Asp Ile Ile Val   Ile Glu Gly Glu Lys   Leu Ser Ile 
    15320                 15325                 15330             


Pro Val   Pro Phe Arg Ala Val   Pro Val Pro Thr Val   Ser Trp His 
    15335                 15340                 15345             


Lys Asp   Gly Lys Glu Val Lys   Ala Ser Asp Arg Leu   Thr Met Lys 
    15350                 15355                 15360             


Asn Asp   His Ile Ser Ala His   Leu Glu Val Pro Lys   Ser Val Arg 
    15365                 15370                 15375             


Ala Asp   Ala Gly Ile Tyr Thr   Ile Thr Leu Glu Asn   Lys Leu Gly 
    15380                 15385                 15390             


Ser Ala   Thr Ala Ser Ile Asn   Val Lys Val Ile Gly   Leu Pro Gly 
    15395                 15400                 15405             


Pro Cys   Lys Asp Ile Lys Ala   Ser Asp Ile Thr Lys   Ser Ser Cys 
    15410                 15415                 15420             


Lys Leu   Thr Trp Glu Pro Pro   Glu Phe Asp Gly Gly   Thr Pro Ile 
    15425                 15430                 15435             


Leu His   Tyr Val Leu Glu Arg   Arg Glu Ala Gly Arg   Arg Thr Tyr 
    15440                 15445                 15450             


Ile Pro   Val Met Ser Gly Glu   Asn Lys Leu Ser Trp   Thr Val Lys 
    15455                 15460                 15465             


Asp Leu   Ile Pro Asn Gly Glu   Tyr Phe Phe Arg Val   Lys Ala Val 
    15470                 15475                 15480             


Asn Lys   Val Gly Gly Gly Glu   Tyr Ile Glu Leu Lys   Asn Pro Val 
    15485                 15490                 15495             


Ile Ala   Gln Asp Pro Lys Gln   Pro Pro Asp Pro Pro   Val Asp Val 
    15500                 15505                 15510             


Glu Val   His Asn Pro Thr Ala   Glu Ala Met Thr Ile   Thr Trp Lys 
    15515                 15520                 15525             


Pro Pro   Leu Tyr Asp Gly Gly   Ser Lys Ile Met Gly   Tyr Ile Ile 
    15530                 15535                 15540             


Glu Lys   Ile Ala Lys Gly Glu   Glu Arg Trp Lys Arg   Cys Asn Glu 
    15545                 15550                 15555             


His Leu   Val Pro Ile Leu Thr   Tyr Thr Ala Lys Gly   Leu Glu Glu 
    15560                 15565                 15570             


Gly Lys   Glu Tyr Gln Phe Arg   Val Arg Ala Glu Asn   Ala Ala Gly 
    15575                 15580                 15585             


Ile Ser   Glu Pro Ser Arg Ala   Thr Pro Pro Thr Lys   Ala Val Asp 
    15590                 15595                 15600             


Pro Ile   Asp Ala Pro Lys Val   Ile Leu Arg Thr Ser   Leu Glu Val 
    15605                 15610                 15615             


Lys Arg   Gly Asp Glu Ile Ala   Leu Asp Ala Ser Ile   Ser Gly Ser 
    15620                 15625                 15630             


Pro Tyr   Pro Thr Ile Thr Trp   Ile Lys Asp Glu Asn   Val Ile Val 
    15635                 15640                 15645             


Pro Glu   Glu Ile Lys Lys Arg   Ala Ala Pro Leu Val   Arg Arg Arg 
    15650                 15655                 15660             


Lys Gly   Glu Val Gln Glu Glu   Glu Pro Phe Val Leu   Pro Leu Thr 
    15665                 15670                 15675             


Gln Arg   Leu Ser Ile Asp Asn   Ser Lys Lys Gly Glu   Ser Gln Leu 
    15680                 15685                 15690             


Arg Val   Arg Asp Ser Leu Arg   Pro Asp His Gly Leu   Tyr Met Ile 
    15695                 15700                 15705             


Lys Val   Glu Asn Asp His Gly   Ile Ala Lys Ala Pro   Cys Thr Val 
    15710                 15715                 15720             


Ser Val   Leu Asp Thr Pro Gly   Pro Pro Ile Asn Phe   Val Phe Glu 
    15725                 15730                 15735             


Asp Ile   Arg Lys Thr Ser Val   Leu Cys Lys Trp Glu   Pro Pro Leu 
    15740                 15745                 15750             


Asp Asp   Gly Gly Ser Glu Ile   Ile Asn Tyr Thr Leu   Glu Lys Lys 
    15755                 15760                 15765             


Asp Lys   Thr Lys Pro Asp Ser   Glu Trp Ile Val Val   Thr Ser Thr 
    15770                 15775                 15780             


Leu Arg   His Cys Lys Tyr Ser   Val Thr Lys Leu Ile   Glu Gly Lys 
    15785                 15790                 15795             


Glu Tyr   Leu Phe Arg Val Arg   Ala Glu Asn Arg Phe   Gly Pro Gly 
    15800                 15805                 15810             


Pro Pro   Cys Val Ser Lys Pro   Leu Val Ala Lys Asp   Pro Phe Gly 
    15815                 15820                 15825             


Pro Pro   Asp Ala Pro Asp Lys   Pro Ile Val Glu Asp   Val Thr Ser 
    15830                 15835                 15840             


Asn Ser   Met Leu Val Lys Trp   Asn Glu Pro Lys Asp   Asn Gly Ser 
    15845                 15850                 15855             


Pro Ile   Leu Gly Tyr Trp Leu   Glu Lys Arg Glu Val   Asn Ser Thr 
    15860                 15865                 15870             


His Trp   Ser Arg Val Asn Lys   Ser Leu Leu Asn Ala   Leu Lys Ala 
    15875                 15880                 15885             


Asn Val   Asp Gly Leu Leu Glu   Gly Leu Thr Tyr Val   Phe Arg Val 
    15890                 15895                 15900             


Cys Ala   Glu Asn Ala Ala Gly   Pro Gly Lys Phe Ser   Pro Pro Ser 
    15905                 15910                 15915             


Asp Pro   Lys Thr Ala His Asp   Pro Ile Ser Pro Pro   Gly Pro Pro 
    15920                 15925                 15930             


Ile Pro   Arg Val Thr Asp Thr   Ser Ser Thr Thr Ile   Glu Leu Glu 
    15935                 15940                 15945             


Trp Glu   Pro Pro Ala Phe Asn   Gly Gly Gly Glu Ile   Val Gly Tyr 
    15950                 15955                 15960             


Phe Val   Asp Lys Gln Leu Val   Gly Thr Asn Glu Trp   Ser Arg Cys 
    15965                 15970                 15975             


Thr Glu   Lys Met Ile Lys Val   Arg Gln Tyr Thr Val   Lys Glu Ile 
    15980                 15985                 15990             


Arg Glu   Gly Ala Asp Tyr Lys   Leu Arg Val Ser Ala   Val Asn Ala 
    15995                 16000                 16005             


Ala Gly   Glu Gly Pro Pro Gly   Glu Thr Gln Pro Val   Thr Val Ala 
    16010                 16015                 16020             


Glu Pro   Gln Glu Pro Pro Ala   Val Glu Leu Asp Val   Ser Val Lys 
    16025                 16030                 16035             


Gly Gly   Ile Gln Ile Met Ala   Gly Lys Thr Leu Arg   Ile Pro Ala 
    16040                 16045                 16050             


Val Val   Thr Gly Arg Pro Val   Pro Thr Lys Val Trp   Thr Lys Glu 
    16055                 16060                 16065             


Glu Gly   Glu Leu Asp Lys Asp   Arg Val Val Ile Asp   Asn Val Gly 
    16070                 16075                 16080             


Thr Lys   Ser Glu Leu Ile Ile   Lys Asp Ala Leu Arg   Lys Asp His 
    16085                 16090                 16095             


Gly Arg   Tyr Val Ile Thr Ala   Thr Asn Ser Cys Gly   Ser Lys Phe 
    16100                 16105                 16110             


Ala Ala   Ala Arg Val Glu Val   Phe Asp Val Pro Gly   Pro Val Leu 
    16115                 16120                 16125             


Asp Leu   Lys Pro Val Val Thr   Asn Arg Lys Met Cys   Leu Leu Asn 
    16130                 16135                 16140             


Trp Ser   Asp Pro Glu Asp Asp   Gly Gly Ser Glu Ile   Thr Gly Phe 
    16145                 16150                 16155             


Ile Ile   Glu Arg Lys Asp Ala   Lys Met His Thr Trp   Arg Gln Pro 
    16160                 16165                 16170             


Ile Glu   Thr Glu Arg Ser Lys   Cys Asp Ile Thr Gly   Leu Leu Glu 
    16175                 16180                 16185             


Gly Gln   Glu Tyr Lys Phe Arg   Val Ile Ala Lys Asn   Lys Phe Gly 
    16190                 16195                 16200             


Cys Gly   Pro Pro Val Glu Ile   Gly Pro Ile Leu Ala   Val Asp Pro 
    16205                 16210                 16215             


Leu Gly   Pro Pro Thr Ser Pro   Glu Arg Leu Thr Tyr   Thr Glu Arg 
    16220                 16225                 16230             


Thr Lys   Ser Thr Ile Thr Leu   Asp Trp Lys Glu Pro   Arg Ser Asn 
    16235                 16240                 16245             


Gly Gly   Ser Pro Ile Gln Gly   Tyr Ile Ile Glu Lys   Arg Arg His 
    16250                 16255                 16260             


Asp Lys   Pro Asp Phe Glu Arg   Val Asn Lys Arg Leu   Cys Pro Thr 
    16265                 16270                 16275             


Thr Ser   Phe Leu Val Glu Asn   Leu Asp Glu His Gln   Met Tyr Glu 
    16280                 16285                 16290             


Phe Arg   Val Lys Ala Val Asn   Glu Ile Gly Glu Ser   Glu Pro Ser 
    16295                 16300                 16305             


Leu Pro   Leu Asn Val Val Ile   Gln Asp Asp Glu Val   Pro Pro Thr 
    16310                 16315                 16320             


Ile Lys   Leu Arg Leu Ser Val   Arg Gly Asp Thr Ile   Lys Val Lys 
    16325                 16330                 16335             


Ala Gly   Glu Pro Val His Ile   Pro Ala Asp Val Thr   Gly Leu Pro 
    16340                 16345                 16350             


Met Pro   Lys Ile Glu Trp Ser   Lys Asn Glu Thr Val   Ile Glu Lys 
    16355                 16360                 16365             


Pro Thr   Asp Ala Leu Gln Ile   Thr Lys Glu Glu Val   Ser Arg Ser 
    16370                 16375                 16380             


Glu Ala   Lys Thr Glu Leu Ser   Ile Pro Lys Ala Val   Arg Glu Asp 
    16385                 16390                 16395             


Lys Gly   Thr Tyr Thr Val Thr   Ala Ser Asn Arg Leu   Gly Ser Val 
    16400                 16405                 16410             


Phe Arg   Asn Val His Val Glu   Val Tyr Asp Arg Pro   Ser Pro Pro 
    16415                 16420                 16425             


Arg Asn   Leu Ala Val Thr Asp   Ile Lys Ala Glu Ser   Cys Tyr Leu 
    16430                 16435                 16440             


Thr Trp   Asp Ala Pro Leu Asp   Asn Gly Gly Ser Glu   Ile Thr His 
    16445                 16450                 16455             


Tyr Val   Ile Asp Lys Arg Asp   Ala Ser Arg Lys Lys   Ala Glu Trp 
    16460                 16465                 16470             


Glu Glu   Val Thr Asn Thr Ala   Val Glu Lys Arg Tyr   Gly Ile Trp 
    16475                 16480                 16485             


Lys Leu   Ile Pro Asn Gly Gln   Tyr Glu Phe Arg Val   Arg Ala Val 
    16490                 16495                 16500             


Asn Lys   Tyr Gly Ile Ser Asp   Glu Cys Lys Ser Asp   Lys Val Val 
    16505                 16510                 16515             


Ile Gln   Asp Pro Tyr Arg Leu   Pro Gly Pro Pro Gly   Lys Pro Lys 
    16520                 16525                 16530             


Val Leu   Ala Arg Thr Lys Gly   Ser Met Leu Val Ser   Trp Thr Pro 
    16535                 16540                 16545             


Pro Leu   Asp Asn Gly Gly Ser   Pro Ile Thr Gly Tyr   Trp Leu Glu 
    16550                 16555                 16560             


Lys Arg   Glu Glu Gly Ser Pro   Tyr Trp Ser Arg Val   Ser Arg Ala 
    16565                 16570                 16575             


Pro Ile   Thr Lys Val Gly Leu   Lys Gly Val Glu Phe   Asn Val Pro 
    16580                 16585                 16590             


Arg Leu   Leu Glu Gly Val Lys   Tyr Gln Phe Arg Ala   Met Ala Ile 
    16595                 16600                 16605             


Asn Ala   Ala Gly Ile Gly Pro   Pro Ser Glu Pro Ser   Asp Pro Glu 
    16610                 16615                 16620             


Val Ala   Gly Asp Pro Ile Phe   Pro Pro Gly Pro Pro   Ser Cys Pro 
    16625                 16630                 16635             


Glu Val   Lys Asp Lys Thr Lys   Ser Ser Ile Ser Leu   Gly Trp Lys 
    16640                 16645                 16650             


Pro Pro   Ala Lys Asp Gly Gly   Ser Pro Ile Lys Gly   Tyr Ile Val 
    16655                 16660                 16665             


Glu Met   Gln Glu Glu Gly Thr   Thr Asp Trp Lys Arg   Val Asn Glu 
    16670                 16675                 16680             


Pro Asp   Lys Leu Ile Thr Thr   Cys Glu Cys Val Val   Pro Asn Leu 
    16685                 16690                 16695             


Lys Glu   Leu Arg Lys Tyr Arg   Phe Arg Val Lys Ala   Val Asn Glu 
    16700                 16705                 16710             


Ala Gly   Glu Ser Glu Pro Ser   Asp Thr Thr Gly Glu   Ile Pro Ala 
    16715                 16720                 16725             


Thr Asp   Ile Gln Glu Glu Pro   Glu Val Phe Ile Asp   Ile Gly Ala 
    16730                 16735                 16740             


Gln Asp   Cys Leu Val Cys Lys   Ala Gly Ser Gln Ile   Arg Ile Pro 
    16745                 16750                 16755             


Ala Val   Ile Lys Gly Arg Pro   Thr Pro Lys Ser Ser   Trp Glu Phe 
    16760                 16765                 16770             


Asp Gly   Lys Ala Lys Lys Ala   Met Lys Asp Gly Val   His Asp Ile 
    16775                 16780                 16785             


Pro Glu   Asp Ala Gln Leu Glu   Thr Ala Glu Asn Ser   Ser Val Ile 
    16790                 16795                 16800             


Ile Ile   Pro Glu Cys Lys Arg   Ser His Thr Gly Lys   Tyr Ser Ile 
    16805                 16810                 16815             


Thr Ala   Lys Asn Lys Ala Gly   Gln Lys Thr Ala Asn   Cys Arg Val 
    16820                 16825                 16830             


Lys Val   Met Asp Val Pro Gly   Pro Pro Lys Asp Leu   Lys Val Ser 
    16835                 16840                 16845             


Asp Ile   Thr Arg Gly Ser Cys   Arg Leu Ser Trp Lys   Met Pro Asp 
    16850                 16855                 16860             


Asp Asp   Gly Gly Asp Arg Ile   Lys Gly Tyr Val Ile   Glu Lys Arg 
    16865                 16870                 16875             


Thr Ile   Asp Gly Lys Ala Trp   Thr Lys Val Asn Pro   Asp Cys Gly 
    16880                 16885                 16890             


Ser Thr   Thr Phe Val Val Pro   Asp Leu Leu Ser Glu   Gln Gln Tyr 
    16895                 16900                 16905             


Phe Phe   Arg Val Arg Ala Glu   Asn Arg Phe Gly Ile   Gly Pro Pro 
    16910                 16915                 16920             


Val Glu   Thr Ile Gln Arg Thr   Thr Ala Arg Asp Pro   Ile Tyr Pro 
    16925                 16930                 16935             


Pro Asp   Pro Pro Ile Lys Leu   Lys Ile Gly Leu Ile   Thr Lys Asn 
    16940                 16945                 16950             


Thr Val   His Leu Ser Trp Lys   Pro Pro Lys Asn Asp   Gly Gly Ser 
    16955                 16960                 16965             


Pro Val   Thr His Tyr Ile Val   Glu Cys Leu Ala Trp   Asp Pro Thr 
    16970                 16975                 16980             


Gly Thr   Lys Lys Glu Ala Trp   Arg Gln Cys Asn Lys   Arg Asp Val 
    16985                 16990                 16995             


Glu Glu   Leu Gln Phe Thr Val   Glu Asp Leu Val Glu   Gly Gly Glu 
    17000                 17005                 17010             


Tyr Glu   Phe Arg Val Lys Ala   Val Asn Ala Ala Gly   Val Ser Lys 
    17015                 17020                 17025             


Pro Ser   Ala Thr Val Gly Pro   Cys Asp Cys Gln Arg   Pro Asp Met 
    17030                 17035                 17040             


Pro Pro   Ser Ile Asp Leu Lys   Glu Phe Met Glu Val   Glu Glu Gly 
    17045                 17050                 17055             


Thr Asn   Val Asn Ile Val Ala   Lys Ile Lys Gly Val   Pro Phe Pro 
    17060                 17065                 17070             


Thr Leu   Thr Trp Phe Lys Ala   Pro Pro Lys Lys Pro   Asp Asn Lys 
    17075                 17080                 17085             


Glu Pro   Val Leu Tyr Asp Thr   His Val Asn Lys Leu   Val Val Asp 
    17090                 17095                 17100             


Asp Thr   Cys Thr Leu Val Ile   Pro Gln Ser Arg Arg   Ser Asp Thr 
    17105                 17110                 17115             


Gly Leu   Tyr Thr Ile Thr Ala   Val Asn Asn Leu Gly   Thr Ala Ser 
    17120                 17125                 17130             


Lys Glu   Met Arg Leu Asn Val   Leu Gly Arg Pro Gly   Pro Pro Val 
    17135                 17140                 17145             


Gly Pro   Ile Lys Phe Glu Ser   Val Ser Ala Asp Gln   Met Thr Leu 
    17150                 17155                 17160             


Ser Trp   Phe Pro Pro Lys Asp   Asp Gly Gly Ser Lys   Ile Thr Asn 
    17165                 17170                 17175             


Tyr Val   Ile Glu Lys Arg Glu   Ala Asn Arg Lys Thr   Trp Val His 
    17180                 17185                 17190             


Val Ser   Ser Glu Pro Lys Glu   Cys Thr Tyr Thr Ile   Pro Lys Leu 
    17195                 17200                 17205             


Leu Glu   Gly His Glu Tyr Val   Phe Arg Ile Met Ala   Gln Asn Lys 
    17210                 17215                 17220             


Tyr Gly   Ile Gly Glu Pro Leu   Asp Ser Glu Pro Glu   Thr Ala Arg 
    17225                 17230                 17235             


Asn Leu   Phe Ser Val Pro Gly   Ala Pro Asp Lys Pro   Thr Val Ser 
    17240                 17245                 17250             


Ser Val   Thr Arg Asn Ser Met   Thr Val Asn Trp Glu   Glu Pro Glu 
    17255                 17260                 17265             


Tyr Asp   Gly Gly Ser Pro Val   Thr Gly Tyr Trp Leu   Glu Met Lys 
    17270                 17275                 17280             


Asp Thr   Thr Ser Lys Arg Trp   Lys Arg Val Asn Arg   Asp Pro Ile 
    17285                 17290                 17295             


Lys Ala   Met Thr Leu Gly Val   Ser Tyr Lys Val Thr   Gly Leu Ile 
    17300                 17305                 17310             


Glu Gly   Ser Asp Tyr Gln Phe   Arg Val Tyr Ala Ile   Asn Ala Ala 
    17315                 17320                 17325             


Gly Val   Gly Pro Ala Ser Leu   Pro Ser Asp Pro Ala   Thr Ala Arg 
    17330                 17335                 17340             


Asp Pro   Ile Ala Pro Pro Gly   Pro Pro Phe Pro Lys   Val Thr Asp 
    17345                 17350                 17355             


Trp Thr   Lys Ser Ser Ala Asp   Leu Glu Trp Ser Pro   Pro Leu Lys 
    17360                 17365                 17370             


Asp Gly   Gly Ser Lys Val Thr   Gly Tyr Ile Val Glu   Tyr Lys Glu 
    17375                 17380                 17385             


Glu Gly   Lys Glu Glu Trp Glu   Lys Gly Lys Asp Lys   Glu Val Arg 
    17390                 17395                 17400             


Gly Thr   Lys Leu Val Val Thr   Gly Leu Lys Glu Gly   Ala Phe Tyr 
    17405                 17410                 17415             


Lys Phe   Arg Val Ser Ala Val   Asn Ile Ala Gly Ile   Gly Glu Pro 
    17420                 17425                 17430             


Gly Glu   Val Thr Asp Val Ile   Glu Met Lys Asp Arg   Leu Val Ser 
    17435                 17440                 17445             


Pro Asp   Leu Gln Leu Asp Ala   Ser Val Arg Asp Arg   Ile Val Val 
    17450                 17455                 17460             


His Ala   Gly Gly Val Ile Arg   Ile Ile Ala Tyr Val   Ser Gly Lys 
    17465                 17470                 17475             


Pro Pro   Pro Thr Val Thr Trp   Asn Met Asn Glu Arg   Thr Leu Pro 
    17480                 17485                 17490             


Gln Glu   Ala Thr Ile Glu Thr   Thr Ala Ile Ser Ser   Ser Met Val 
    17495                 17500                 17505             


Ile Lys   Asn Cys Gln Arg Ser   His Gln Gly Val Tyr   Ser Leu Leu 
    17510                 17515                 17520             


Ala Lys   Asn Glu Ala Gly Glu   Arg Lys Lys Thr Ile   Ile Val Asp 
    17525                 17530                 17535             


Val Leu   Asp Val Pro Gly Pro   Val Gly Thr Pro Phe   Leu Ala His 
    17540                 17545                 17550             


Asn Leu   Thr Asn Glu Ser Cys   Lys Leu Thr Trp Phe   Ser Pro Glu 
    17555                 17560                 17565             


Asp Asp   Gly Gly Ser Pro Ile   Thr Asn Tyr Val Ile   Glu Lys Arg 
    17570                 17575                 17580             


Glu Ser   Asp Arg Arg Ala Trp   Thr Pro Val Thr Tyr   Thr Val Thr 
    17585                 17590                 17595             


Arg Gln   Asn Ala Thr Val Gln   Gly Leu Ile Gln Gly   Lys Ala Tyr 
    17600                 17605                 17610             


Phe Phe   Arg Ile Ala Ala Glu   Asn Ser Ile Gly Met   Gly Pro Phe 
    17615                 17620                 17625             


Val Glu   Thr Ser Glu Ala Leu   Val Ile Arg Glu Pro   Ile Thr Val 
    17630                 17635                 17640             


Pro Glu   Arg Pro Glu Asp Leu   Glu Val Lys Glu Val   Thr Lys Asn 
    17645                 17650                 17655             


Thr Val   Thr Leu Thr Trp Asn   Pro Pro Lys Tyr Asp   Gly Gly Ser 
    17660                 17665                 17670             


Glu Ile   Ile Asn Tyr Val Leu   Glu Ser Arg Leu Ile   Gly Thr Glu 
    17675                 17680                 17685             


Lys Phe   His Lys Val Thr Asn   Asp Asn Leu Leu Ser   Arg Lys Tyr 
    17690                 17695                 17700             


Thr Val   Lys Gly Leu Lys Glu   Gly Asp Thr Tyr Glu   Tyr Arg Val 
    17705                 17710                 17715             


Ser Ala   Val Asn Ile Val Gly   Gln Gly Lys Pro Ser   Phe Cys Thr 
    17720                 17725                 17730             


Lys Pro   Ile Thr Cys Lys Asp   Glu Leu Ala Pro Pro   Thr Leu His 
    17735                 17740                 17745             


Leu Asp   Phe Arg Asp Lys Leu   Thr Ile Arg Val Gly   Glu Ala Phe 
    17750                 17755                 17760             


Ala Leu   Thr Gly Arg Tyr Ser   Gly Lys Pro Lys Pro   Lys Val Ser 
    17765                 17770                 17775             


Trp Phe   Lys Asp Glu Ala Asp   Val Leu Glu Asp Asp   Arg Thr His 
    17780                 17785                 17790             


Ile Lys   Thr Thr Pro Ala Thr   Leu Ala Leu Glu Lys   Ile Lys Ala 
    17795                 17800                 17805             


Lys Arg   Ser Asp Ser Gly Lys   Tyr Cys Val Val Val   Glu Asn Ser 
    17810                 17815                 17820             


Thr Gly   Ser Arg Lys Gly Phe   Cys Gln Val Asn Val   Val Asp Arg 
    17825                 17830                 17835             


Pro Gly   Pro Pro Val Gly Pro   Val Ser Phe Asp Glu   Val Thr Lys 
    17840                 17845                 17850             


Asp Tyr   Met Val Ile Ser Trp   Lys Pro Pro Leu Asp   Asp Gly Gly 
    17855                 17860                 17865             


Ser Lys   Ile Thr Asn Tyr Ile   Ile Glu Lys Lys Glu   Val Gly Lys 
    17870                 17875                 17880             


Asp Val   Trp Met Pro Val Thr   Ser Ala Ser Ala Lys   Thr Thr Cys 
    17885                 17890                 17895             


Lys Val   Ser Lys Leu Leu Glu   Gly Lys Asp Tyr Ile   Phe Arg Ile 
    17900                 17905                 17910             


His Ala   Glu Asn Leu Tyr Gly   Ile Ser Asp Pro Leu   Val Ser Asp 
    17915                 17920                 17925             


Ser Met   Lys Ala Lys Asp Arg   Phe Arg Val Pro Asp   Ala Pro Asp 
    17930                 17935                 17940             


Gln Pro   Ile Val Thr Glu Val   Thr Lys Asp Ser Ala   Leu Val Thr 
    17945                 17950                 17955             


Trp Asn   Lys Pro His Asp Gly   Gly Lys Pro Ile Thr   Asn Tyr Ile 
    17960                 17965                 17970             


Leu Glu   Lys Arg Glu Thr Met   Ser Lys Arg Trp Ala   Arg Val Thr 
    17975                 17980                 17985             


Lys Asp   Pro Ile His Pro Tyr   Thr Lys Phe Arg Val   Pro Asp Leu 
    17990                 17995                 18000             


Leu Glu   Gly Cys Gln Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Glu 
    18005                 18010                 18015             


Ile Gly   Ile Gly Asp Pro Ser   Pro Pro Ser Lys Pro   Val Phe Ala 
    18020                 18025                 18030             


Lys Asp   Pro Ile Ala Lys Pro   Ser Pro Pro Val Asn   Pro Glu Ala 
    18035                 18040                 18045             


Ile Asp   Thr Thr Cys Asn Ser   Val Asp Leu Thr Trp   Gln Pro Pro 
    18050                 18055                 18060             


Arg His   Asp Gly Gly Ser Lys   Ile Leu Gly Tyr Ile   Val Glu Tyr 
    18065                 18070                 18075             


Gln Lys   Val Gly Asp Glu Glu   Trp Arg Arg Ala Asn   His Thr Pro 
    18080                 18085                 18090             


Glu Ser   Cys Pro Glu Thr Lys   Tyr Lys Val Thr Gly   Leu Arg Asp 
    18095                 18100                 18105             


Gly Gln   Thr Tyr Lys Phe Arg   Val Leu Ala Val Asn   Ala Ala Gly 
    18110                 18115                 18120             


Glu Ser   Asp Pro Ala His Val   Pro Glu Pro Val Leu   Val Lys Asp 
    18125                 18130                 18135             


Arg Leu   Glu Pro Pro Glu Leu   Ile Leu Asp Ala Asn   Met Ala Arg 
    18140                 18145                 18150             


Glu Gln   His Ile Lys Val Gly   Asp Thr Leu Arg Leu   Ser Ala Ile 
    18155                 18160                 18165             


Ile Lys   Gly Val Pro Phe Pro   Lys Val Thr Trp Lys   Lys Glu Asp 
    18170                 18175                 18180             


Arg Asp   Ala Pro Thr Lys Ala   Arg Ile Asp Val Thr   Pro Val Gly 
    18185                 18190                 18195             


Ser Lys   Leu Glu Ile Arg Asn   Ala Ala His Glu Asp   Gly Gly Ile 
    18200                 18205                 18210             


Tyr Ser   Leu Thr Val Glu Asn   Pro Ala Gly Ser Lys   Thr Val Ser 
    18215                 18220                 18225             


Val Lys   Val Leu Val Leu Asp   Lys Pro Gly Pro Pro   Arg Asp Leu 
    18230                 18235                 18240             


Glu Val   Ser Glu Ile Arg Lys   Asp Ser Cys Tyr Leu   Thr Trp Lys 
    18245                 18250                 18255             


Glu Pro   Leu Asp Asp Gly Gly   Ser Val Ile Thr Asn   Tyr Val Val 
    18260                 18265                 18270             


Glu Arg   Arg Asp Val Ala Ser   Ala Gln Trp Ser Pro   Leu Ser Ala 
    18275                 18280                 18285             


Thr Ser   Lys Lys Lys Ser His   Phe Ala Lys His Leu   Asn Glu Gly 
    18290                 18295                 18300             


Asn Gln   Tyr Leu Phe Arg Val   Ala Ala Glu Asn Gln   Tyr Gly Arg 
    18305                 18310                 18315             


Gly Pro   Phe Val Glu Thr Pro   Lys Pro Ile Lys Ala   Leu Asp Pro 
    18320                 18325                 18330             


Leu His   Pro Pro Gly Pro Pro   Lys Asp Leu His His   Val Asp Val 
    18335                 18340                 18345             


Asp Lys   Thr Glu Val Ser Leu   Val Trp Asn Lys Pro   Asp Arg Asp 
    18350                 18355                 18360             


Gly Gly   Ser Pro Ile Thr Gly   Tyr Leu Val Glu Tyr   Gln Glu Glu 
    18365                 18370                 18375             


Gly Thr   Gln Asp Trp Ile Lys   Phe Lys Thr Val Thr   Asn Leu Glu 
    18380                 18385                 18390             


Cys Val   Val Thr Gly Leu Gln   Gln Gly Lys Thr Tyr   Arg Phe Arg 
    18395                 18400                 18405             


Val Lys   Ala Glu Asn Ile Val   Gly Leu Gly Leu Pro   Asp Thr Thr 
    18410                 18415                 18420             


Ile Pro   Ile Glu Cys Gln Glu   Lys Leu Val Pro Pro   Ser Val Glu 
    18425                 18430                 18435             


Leu Asp   Val Lys Leu Ile Glu   Gly Leu Val Val Lys   Ala Gly Thr 
    18440                 18445                 18450             


Thr Val   Arg Phe Pro Ala Ile   Ile Arg Gly Val Pro   Val Pro Thr 
    18455                 18460                 18465             


Ala Lys   Trp Thr Thr Asp Gly   Ser Glu Ile Lys Thr   Asp Glu His 
    18470                 18475                 18480             


Tyr Thr   Val Glu Thr Asp Asn   Phe Ser Ser Val Leu   Thr Ile Lys 
    18485                 18490                 18495             


Asn Cys   Leu Arg Arg Asp Thr   Gly Glu Tyr Gln Ile   Thr Val Ser 
    18500                 18505                 18510             


Asn Ala   Ala Gly Ser Lys Thr   Val Ala Val His Leu   Thr Val Leu 
    18515                 18520                 18525             


Asp Val   Pro Gly Pro Pro Thr   Gly Pro Ile Asn Ile   Leu Asp Val 
    18530                 18535                 18540             


Thr Pro   Glu His Met Thr Ile   Ser Trp Gln Pro Pro   Lys Asp Asp 
    18545                 18550                 18555             


Gly Gly   Ser Pro Val Ile Asn   Tyr Ile Val Glu Lys   Gln Asp Thr 
    18560                 18565                 18570             


Arg Lys   Asp Thr Trp Gly Val   Val Ser Ser Gly Ser   Ser Lys Thr 
    18575                 18580                 18585             


Lys Leu   Lys Ile Pro His Leu   Gln Lys Gly Cys Glu   Tyr Val Phe 
    18590                 18595                 18600             


Arg Val   Arg Ala Glu Asn Lys   Ile Gly Val Gly Pro   Pro Leu Asp 
    18605                 18610                 18615             


Ser Thr   Pro Thr Val Ala Lys   His Lys Phe Ser Pro   Pro Ser Pro 
    18620                 18625                 18630             


Pro Gly   Lys Pro Val Val Thr   Asp Ile Thr Glu Asn   Ala Ala Thr 
    18635                 18640                 18645             


Val Ser   Trp Thr Leu Pro Lys   Ser Asp Gly Gly Ser   Pro Ile Thr 
    18650                 18655                 18660             


Gly Tyr   Tyr Met Glu Arg Arg   Glu Val Thr Gly Lys   Trp Val Arg 
    18665                 18670                 18675             


Val Asn   Lys Thr Pro Ile Ala   Asp Leu Lys Phe Arg   Val Thr Gly 
    18680                 18685                 18690             


Leu Tyr   Glu Gly Asn Thr Tyr   Glu Phe Arg Val Phe   Ala Glu Asn 
    18695                 18700                 18705             


Leu Ala   Gly Leu Ser Lys Pro   Ser Pro Ser Ser Asp   Pro Ile Lys 
    18710                 18715                 18720             


Ala Cys   Arg Pro Ile Lys Pro   Pro Gly Pro Pro Ile   Asn Pro Lys 
    18725                 18730                 18735             


Leu Lys   Asp Lys Ser Arg Glu   Thr Ala Asp Leu Val   Trp Thr Lys 
    18740                 18745                 18750             


Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu Gly Tyr   Val Val Glu 
    18755                 18760                 18765             


Cys Gln   Lys Pro Gly Thr Ala   Gln Trp Asn Arg Ile   Asn Lys Asp 
    18770                 18775                 18780             


Glu Leu   Ile Arg Gln Cys Ala   Phe Arg Val Pro Gly   Leu Ile Glu 
    18785                 18790                 18795             


Gly Asn   Glu Tyr Arg Phe Arg   Ile Lys Ala Ala Asn   Ile Val Gly 
    18800                 18805                 18810             


Glu Gly   Glu Pro Arg Glu Leu   Ala Glu Ser Val Ile   Ala Lys Asp 
    18815                 18820                 18825             


Ile Leu   His Pro Pro Glu Val   Glu Leu Asp Val Thr   Cys Arg Asp 
    18830                 18835                 18840             


Val Ile   Thr Val Arg Val Gly   Gln Thr Ile Arg Ile   Leu Ala Arg 
    18845                 18850                 18855             


Val Lys   Gly Arg Pro Glu Pro   Asp Ile Thr Trp Thr   Lys Glu Gly 
    18860                 18865                 18870             


Lys Val   Leu Val Arg Glu Lys   Arg Val Asp Leu Ile   Gln Asp Leu 
    18875                 18880                 18885             


Pro Arg   Val Glu Leu Gln Ile   Lys Glu Ala Val Arg   Ala Asp His 
    18890                 18895                 18900             


Gly Lys   Tyr Ile Ile Ser Ala   Lys Asn Ser Ser Gly   His Ala Gln 
    18905                 18910                 18915             


Gly Ser   Ala Ile Val Asn Val   Leu Asp Arg Pro Gly   Pro Cys Gln 
    18920                 18925                 18930             


Asn Leu   Lys Val Thr Asn Val   Thr Lys Glu Asn Cys   Thr Ile Ser 
    18935                 18940                 18945             


Trp Glu   Asn Pro Leu Asp Asn   Gly Gly Ser Glu Ile   Thr Asn Phe 
    18950                 18955                 18960             


Ile Val   Glu Tyr Arg Lys Pro   Asn Gln Lys Gly Trp   Ser Ile Val 
    18965                 18970                 18975             


Ala Ser   Asp Val Thr Lys Arg   Leu Ile Lys Ala Asn   Leu Leu Ala 
    18980                 18985                 18990             


Asn Asn   Glu Tyr Tyr Phe Arg   Val Cys Ala Glu Asn   Lys Val Gly 
    18995                 19000                 19005             


Val Gly   Pro Thr Ile Glu Thr   Lys Thr Pro Ile Leu   Ala Ile Asn 
    19010                 19015                 19020             


Pro Ile   Asp Arg Pro Gly Glu   Pro Glu Asn Leu His   Ile Ala Asp 
    19025                 19030                 19035             


Lys Gly   Lys Thr Phe Val Tyr   Leu Lys Trp Arg Arg   Pro Asp Tyr 
    19040                 19045                 19050             


Asp Gly   Gly Ser Pro Asn Leu   Ser Tyr His Val Glu   Arg Arg Leu 
    19055                 19060                 19065             


Lys Gly   Ser Asp Asp Trp Glu   Arg Val His Lys Gly   Ser Ile Lys 
    19070                 19075                 19080             


Glu Thr   His Tyr Met Val Asp   Arg Cys Val Glu Asn   Gln Ile Tyr 
    19085                 19090                 19095             


Glu Phe   Arg Val Gln Thr Lys   Asn Glu Gly Gly Glu   Ser Asp Trp 
    19100                 19105                 19110             


Val Lys   Thr Glu Glu Val Val   Val Lys Glu Asp Leu   Gln Lys Pro 
    19115                 19120                 19125             


Val Leu   Asp Leu Lys Leu Ser   Gly Val Leu Thr Val   Lys Ala Gly 
    19130                 19135                 19140             


Asp Thr   Ile Arg Leu Glu Ala   Gly Val Arg Gly Lys   Pro Phe Pro 
    19145                 19150                 19155             


Glu Val   Ala Trp Thr Lys Asp   Lys Asp Ala Thr Asp   Leu Thr Arg 
    19160                 19165                 19170             


Ser Pro   Arg Val Lys Ile Asp   Thr Arg Ala Asp Ser   Ser Lys Phe 
    19175                 19180                 19185             


Ser Leu   Thr Lys Ala Lys Arg   Ser Asp Gly Gly Lys   Tyr Val Val 
    19190                 19195                 19200             


Thr Ala   Thr Asn Thr Ala Gly   Ser Phe Val Ala Tyr   Ala Thr Val 
    19205                 19210                 19215             


Asn Val   Leu Asp Lys Pro Gly   Pro Val Arg Asn Leu   Lys Ile Val 
    19220                 19225                 19230             


Asp Val   Ser Ser Asp Arg Cys   Thr Val Cys Trp Asp   Pro Pro Glu 
    19235                 19240                 19245             


Asp Asp   Gly Gly Cys Glu Ile   Gln Asn Tyr Ile Leu   Glu Lys Cys 
    19250                 19255                 19260             


Glu Thr   Lys Arg Met Val Trp   Ser Thr Tyr Ser Ala   Thr Val Leu 
    19265                 19270                 19275             


Thr Pro   Gly Thr Thr Val Thr   Arg Leu Ile Glu Gly   Asn Glu Tyr 
    19280                 19285                 19290             


Ile Phe   Arg Val Arg Ala Glu   Asn Lys Ile Gly Thr   Gly Pro Pro 
    19295                 19300                 19305             


Thr Glu   Ser Lys Pro Val Ile   Ala Lys Thr Lys Tyr   Asp Lys Pro 
    19310                 19315                 19320             


Gly Arg   Pro Asp Pro Pro Glu   Val Thr Lys Val Ser   Lys Glu Glu 
    19325                 19330                 19335             


Met Thr   Val Val Trp Asn Pro   Pro Glu Tyr Asp Gly   Gly Lys Ser 
    19340                 19345                 19350             


Ile Thr   Gly Tyr Phe Leu Glu   Lys Lys Glu Lys His   Ser Thr Arg 
    19355                 19360                 19365             


Trp Val   Pro Val Asn Lys Ser   Ala Ile Pro Glu Arg   Arg Met Lys 
    19370                 19375                 19380             


Val Gln   Asn Leu Leu Pro Asp   His Glu Tyr Gln Phe   Arg Val Lys 
    19385                 19390                 19395             


Ala Glu   Asn Glu Ile Gly Ile   Gly Glu Pro Ser Leu   Pro Ser Arg 
    19400                 19405                 19410             


Pro Val   Val Ala Lys Asp Pro   Ile Glu Pro Pro Gly   Pro Pro Thr 
    19415                 19420                 19425             


Asn Phe   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Thr Leu Gly 
    19430                 19435                 19440             


Trp Gly   Lys Pro Val Tyr Asp   Gly Gly Ala Pro Ile   Ile Gly Tyr 
    19445                 19450                 19455             


Val Val   Glu Met Arg Pro Lys   Ile Ala Asp Ala Ser   Pro Asp Glu 
    19460                 19465                 19470             


Gly Trp   Lys Arg Cys Asn Ala   Ala Ala Gln Leu Val   Arg Lys Glu 
    19475                 19480                 19485             


Phe Thr   Val Thr Ser Leu Asp   Glu Asn Gln Glu Tyr   Glu Phe Arg 
    19490                 19495                 19500             


Val Cys   Ala Gln Asn Gln Val   Gly Ile Gly Arg Pro   Ala Glu Leu 
    19505                 19510                 19515             


Lys Glu   Ala Ile Lys Pro Lys   Glu Ile Leu Glu Pro   Pro Glu Ile 
    19520                 19525                 19530             


Asp Leu   Asp Ala Ser Met Arg   Lys Leu Val Ile Val   Arg Ala Gly 
    19535                 19540                 19545             


Cys Pro   Ile Arg Leu Phe Ala   Ile Val Arg Gly Arg   Pro Ala Pro 
    19550                 19555                 19560             


Lys Val   Thr Trp Arg Lys Val   Gly Ile Asp Asn Val   Val Arg Lys 
    19565                 19570                 19575             


Gly Gln   Val Asp Leu Val Asp   Thr Met Ala Phe Leu   Val Ile Pro 
    19580                 19585                 19590             


Asn Ser   Thr Arg Asp Asp Ser   Gly Lys Tyr Ser Leu   Thr Leu Val 
    19595                 19600                 19605             


Asn Pro   Ala Gly Glu Lys Ala   Val Phe Val Asn Val   Arg Val Leu 
    19610                 19615                 19620             


Asp Thr   Pro Gly Pro Val Ser   Asp Leu Lys Val Ser   Asp Val Thr 
    19625                 19630                 19635             


Lys Thr   Ser Cys His Val Ser   Trp Ala Pro Pro Glu   Asn Asp Gly 
    19640                 19645                 19650             


Gly Ser   Gln Val Thr His Tyr   Ile Val Glu Lys Arg   Glu Ala Asp 
    19655                 19660                 19665             


Arg Lys   Thr Trp Ser Thr Val   Thr Pro Glu Val Lys   Lys Thr Ser 
    19670                 19675                 19680             


Phe His   Val Thr Asn Leu Val   Pro Gly Asn Glu Tyr   Tyr Phe Arg 
    19685                 19690                 19695             


Val Thr   Ala Val Asn Glu Tyr   Gly Pro Gly Val Pro   Thr Asp Val 
    19700                 19705                 19710             


Pro Lys   Pro Val Leu Ala Ser   Asp Pro Leu Ser Glu   Pro Asp Pro 
    19715                 19720                 19725             


Pro Arg   Lys Leu Glu Val Thr   Glu Met Thr Lys Asn   Ser Ala Thr 
    19730                 19735                 19740             


Leu Ala   Trp Leu Pro Pro Leu   Arg Asp Gly Gly Ala   Lys Ile Asp 
    19745                 19750                 19755             


Gly Tyr   Ile Thr Ser Tyr Arg   Glu Glu Glu Gln Pro   Ala Asp Arg 
    19760                 19765                 19770             


Trp Thr   Glu Tyr Ser Val Val   Lys Asp Leu Ser Leu   Val Val Thr 
    19775                 19780                 19785             


Gly Leu   Lys Glu Gly Lys Lys   Tyr Lys Phe Arg Val   Ala Ala Arg 
    19790                 19795                 19800             


Asn Ala   Val Gly Val Ser Leu   Pro Arg Glu Ala Glu   Gly Val Tyr 
    19805                 19810                 19815             


Glu Ala   Lys Glu Gln Leu Leu   Pro Pro Lys Ile Leu   Met Pro Glu 
    19820                 19825                 19830             


Gln Ile   Thr Ile Lys Ala Gly   Lys Lys Leu Arg Ile   Glu Ala His 
    19835                 19840                 19845             


Val Tyr   Gly Lys Pro His Pro   Thr Cys Lys Trp Lys   Lys Gly Glu 
    19850                 19855                 19860             


Asp Glu   Val Val Thr Ser Ser   His Leu Ala Val His   Lys Ala Asp 
    19865                 19870                 19875             


Ser Ser   Ser Ile Leu Ile Ile   Lys Asp Val Thr Arg   Lys Asp Ser 
    19880                 19885                 19890             


Gly Tyr   Tyr Ser Leu Thr Ala   Glu Asn Ser Ser Gly   Thr Asp Thr 
    19895                 19900                 19905             


Gln Lys   Ile Lys Val Val Val   Met Asp Ala Pro Gly   Pro Pro Gln 
    19910                 19915                 19920             


Pro Pro   Phe Asp Ile Ser Asp   Ile Asp Ala Asp Ala   Cys Ser Leu 
    19925                 19930                 19935             


Ser Trp   His Ile Pro Leu Glu   Asp Gly Gly Ser Asn   Ile Thr Asn 
    19940                 19945                 19950             


Tyr Ile   Val Glu Lys Cys Asp   Val Ser Arg Gly Asp   Trp Val Thr 
    19955                 19960                 19965             


Ala Leu   Ala Ser Val Thr Lys   Thr Ser Cys Arg Val   Gly Lys Leu 
    19970                 19975                 19980             


Ile Pro   Gly Gln Glu Tyr Ile   Phe Arg Val Arg Ala   Glu Asn Arg 
    19985                 19990                 19995             


Phe Gly   Ile Ser Glu Pro Leu   Thr Ser Pro Lys Met   Val Ala Gln 
    20000                 20005                 20010             


Phe Pro   Phe Gly Val Pro Ser   Glu Pro Lys Asn Ala   Arg Val Thr 
    20015                 20020                 20025             


Lys Val   Asn Lys Asp Cys Ile   Phe Val Ala Trp Asp   Arg Pro Asp 
    20030                 20035                 20040             


Ser Asp   Gly Gly Ser Pro Ile   Ile Gly Tyr Leu Ile   Glu Arg Lys 
    20045                 20050                 20055             


Glu Arg   Asn Ser Leu Leu Trp   Val Lys Ala Asn Asp   Thr Leu Val 
    20060                 20065                 20070             


Arg Ser   Thr Glu Tyr Pro Cys   Ala Gly Leu Val Glu   Gly Leu Glu 
    20075                 20080                 20085             


Tyr Ser   Phe Arg Ile Tyr Ala   Leu Asn Lys Ala Gly   Ser Ser Pro 
    20090                 20095                 20100             


Pro Ser   Lys Pro Thr Glu Tyr   Val Thr Ala Arg Met   Pro Val Asp 
    20105                 20110                 20115             


Pro Pro   Gly Lys Pro Glu Val   Ile Asp Val Thr Lys   Ser Thr Val 
    20120                 20125                 20130             


Ser Leu   Ile Trp Ala Arg Pro   Lys His Asp Gly Gly   Ser Lys Ile 
    20135                 20140                 20145             


Ile Gly   Tyr Phe Val Glu Ala   Cys Lys Leu Pro Gly   Asp Lys Trp 
    20150                 20155                 20160             


Val Arg   Cys Asn Thr Ala Pro   His Gln Ile Pro Gln   Glu Glu Tyr 
    20165                 20170                 20175             


Thr Ala   Thr Gly Leu Glu Glu   Lys Ala Gln Tyr Gln   Phe Arg Ala 
    20180                 20185                 20190             


Ile Ala   Arg Thr Ala Val Asn   Ile Ser Pro Pro Ser   Glu Pro Ser 
    20195                 20200                 20205             


Asp Pro   Val Thr Ile Leu Ala   Glu Asn Val Pro Pro   Arg Ile Asp 
    20210                 20215                 20220             


Leu Ser   Val Ala Met Lys Ser   Leu Leu Thr Val Lys   Ala Gly Thr 
    20225                 20230                 20235             


Asn Val   Cys Leu Asp Ala Thr   Val Phe Gly Lys Pro   Met Pro Thr 
    20240                 20245                 20250             


Val Ser   Trp Lys Lys Asp Gly   Thr Leu Leu Lys Pro   Ala Glu Gly 
    20255                 20260                 20265             


Ile Lys   Met Ala Met Gln Arg   Asn Leu Cys Thr Leu   Glu Leu Phe 
    20270                 20275                 20280             


Ser Val   Asn Arg Lys Asp Ser   Gly Asp Tyr Thr Ile   Thr Ala Glu 
    20285                 20290                 20295             


Asn Ser   Ser Gly Ser Lys Ser   Ala Thr Ile Lys Leu   Lys Val Leu 
    20300                 20305                 20310             


Asp Lys   Pro Gly Pro Pro Ala   Ser Val Lys Ile Asn   Lys Met Tyr 
    20315                 20320                 20325             


Ser Asp   Arg Ala Met Leu Ser   Trp Glu Pro Pro Leu   Glu Asp Gly 
    20330                 20335                 20340             


Gly Ser   Glu Ile Thr Asn Tyr   Ile Val Asp Lys Arg   Glu Thr Ser 
    20345                 20350                 20355             


Arg Pro   Asn Trp Ala Gln Val   Ser Ala Thr Val Pro   Ile Thr Ser 
    20360                 20365                 20370             


Cys Ser   Val Glu Lys Leu Ile   Glu Gly His Glu Tyr   Gln Phe Arg 
    20375                 20380                 20385             


Ile Cys   Ala Glu Asn Lys Tyr   Gly Val Gly Asp Pro   Val Phe Thr 
    20390                 20395                 20400             


Glu Pro   Ala Ile Ala Lys Asn   Pro Tyr Asp Pro Pro   Gly Arg Cys 
    20405                 20410                 20415             


Asp Pro   Pro Val Ile Ser Asn   Ile Thr Lys Asp His   Met Thr Val 
    20420                 20425                 20430             


Ser Trp   Lys Pro Pro Ala Asp   Asp Gly Gly Ser Pro   Ile Thr Gly 
    20435                 20440                 20445             


Tyr Leu   Leu Glu Lys Arg Glu   Thr Gln Ala Val Asn   Trp Thr Lys 
    20450                 20455                 20460             


Val Asn   Arg Lys Pro Ile Ile   Glu Arg Thr Leu Lys   Ala Thr Gly 
    20465                 20470                 20475             


Leu Gln   Glu Gly Thr Glu Tyr   Glu Phe Arg Val Thr   Ala Ile Asn 
    20480                 20485                 20490             


Lys Ala   Gly Pro Gly Lys Pro   Ser Asp Ala Ser Lys   Ala Ala Tyr 
    20495                 20500                 20505             


Ala Arg   Asp Pro Gln Tyr Pro   Pro Ala Pro Pro Ala   Phe Pro Lys 
    20510                 20515                 20520             


Val Tyr   Asp Thr Thr Arg Ser   Ser Val Ser Leu Ser   Trp Gly Lys 
    20525                 20530                 20535             


Pro Ala   Tyr Asp Gly Gly Ser   Pro Ile Ile Gly Tyr   Leu Val Glu 
    20540                 20545                 20550             


Val Lys   Arg Ala Asp Ser Asp   Asn Trp Val Arg Cys   Asn Leu Pro 
    20555                 20560                 20565             


Gln Asn   Leu Gln Lys Thr Arg   Phe Glu Val Thr Gly   Leu Met Glu 
    20570                 20575                 20580             


Asp Thr   Gln Tyr Gln Phe Arg   Val Tyr Ala Val Asn   Lys Ile Gly 
    20585                 20590                 20595             


Tyr Ser   Asp Pro Ser Asp Val   Pro Asp Lys His Tyr   Pro Lys Asp 
    20600                 20605                 20610             


Ile Leu   Ile Pro Pro Glu Gly   Glu Leu Asp Ala Asp   Leu Arg Lys 
    20615                 20620                 20625             


Thr Leu   Ile Leu Arg Ala Gly   Val Thr Met Arg Leu   Tyr Val Pro 
    20630                 20635                 20640             


Val Lys   Gly Arg Pro Pro Pro   Lys Ile Thr Trp Ser   Lys Pro Asn 
    20645                 20650                 20655             


Val Asn   Leu Arg Asp Arg Ile   Gly Leu Asp Ile Lys   Ser Thr Asp 
    20660                 20665                 20670             


Phe Asp   Thr Phe Leu Arg Cys   Glu Asn Val Asn Lys   Tyr Asp Ala 
    20675                 20680                 20685             


Gly Lys   Tyr Ile Leu Thr Leu   Glu Asn Ser Cys Gly   Lys Lys Glu 
    20690                 20695                 20700             


Tyr Thr   Ile Val Val Lys Val   Leu Asp Thr Pro Gly   Pro Pro Val 
    20705                 20710                 20715             


Asn Val   Thr Val Lys Glu Ile   Ser Lys Asp Ser Ala   Tyr Val Thr 
    20720                 20725                 20730             


Trp Glu   Pro Pro Ile Ile Asp   Gly Gly Ser Pro Ile   Ile Asn Tyr 
    20735                 20740                 20745             


Val Val   Gln Lys Arg Asp Ala   Glu Arg Lys Ser Trp   Ser Thr Val 
    20750                 20755                 20760             


Thr Thr   Glu Cys Ser Lys Thr   Ser Phe Arg Val Ala   Asn Leu Glu 
    20765                 20770                 20775             


Glu Gly   Lys Ser Tyr Phe Phe   Arg Val Phe Ala Glu   Asn Glu Tyr 
    20780                 20785                 20790             


Gly Ile   Gly Asp Pro Gly Glu   Thr Arg Asp Ala Val   Lys Ala Ser 
    20795                 20800                 20805             


Gln Thr   Pro Gly Pro Val Val   Asp Leu Lys Val Arg   Ser Val Ser 
    20810                 20815                 20820             


Lys Ser   Ser Cys Ser Ile Gly   Trp Lys Lys Pro His   Ser Asp Gly 
    20825                 20830                 20835             


Gly Ser   Arg Ile Ile Gly Tyr   Val Val Asp Phe Leu   Thr Glu Glu 
    20840                 20845                 20850             


Asn Lys   Trp Gln Arg Val Met   Lys Ser Leu Ser Leu   Gln Tyr Ser 
    20855                 20860                 20865             


Ala Lys   Asp Leu Thr Glu Gly   Lys Glu Tyr Thr Phe   Arg Val Ser 
    20870                 20875                 20880             


Ala Glu   Asn Glu Asn Gly Glu   Gly Thr Pro Ser Glu   Ile Thr Val 
    20885                 20890                 20895             


Val Ala   Arg Asp Asp Val Val   Ala Pro Asp Leu Asp   Leu Lys Gly 
    20900                 20905                 20910             


Leu Pro   Asp Leu Cys Tyr Leu   Ala Lys Glu Asn Ser   Asn Phe Arg 
    20915                 20920                 20925             


Leu Lys   Ile Pro Ile Lys Gly   Lys Pro Ala Pro Ser   Val Ser Trp 
    20930                 20935                 20940             


Lys Lys   Gly Glu Asp Pro Leu   Ala Thr Asp Thr Arg   Val Ser Val 
    20945                 20950                 20955             


Glu Ser   Ser Ala Val Asn Thr   Thr Leu Ile Val Tyr   Asp Cys Gln 
    20960                 20965                 20970             


Lys Ser   Asp Ala Gly Lys Tyr   Thr Ile Thr Leu Lys   Asn Val Ala 
    20975                 20980                 20985             


Gly Thr   Lys Glu Gly Thr Ile   Ser Ile Lys Val Val   Gly Lys Pro 
    20990                 20995                 21000             


Gly Ile   Pro Thr Gly Pro Ile   Lys Phe Asp Glu Val   Thr Ala Glu 
    21005                 21010                 21015             


Ala Met   Thr Leu Lys Trp Ala   Pro Pro Lys Asp Asp   Gly Gly Ser 
    21020                 21025                 21030             


Glu Ile   Thr Asn Tyr Ile Leu   Glu Lys Arg Asp Ser   Val Asn Asn 
    21035                 21040                 21045             


Lys Trp   Val Thr Cys Ala Ser   Ala Val Gln Lys Thr   Thr Phe Arg 
    21050                 21055                 21060             


Val Thr   Arg Leu His Glu Gly   Met Glu Tyr Thr Phe   Arg Val Ser 
    21065                 21070                 21075             


Ala Glu   Asn Lys Tyr Gly Val   Gly Glu Gly Leu Lys   Ser Glu Pro 
    21080                 21085                 21090             


Ile Val   Ala Arg His Pro Phe   Asp Val Pro Asp Ala   Pro Pro Pro 
    21095                 21100                 21105             


Pro Asn   Ile Val Asp Val Arg   His Asp Ser Val Ser   Leu Thr Trp 
    21110                 21115                 21120             


Thr Asp   Pro Lys Lys Thr Gly   Gly Ser Pro Ile Thr   Gly Tyr His 
    21125                 21130                 21135             


Leu Glu   Phe Lys Glu Arg Asn   Ser Leu Leu Trp Lys   Arg Ala Asn 
    21140                 21145                 21150             


Lys Thr   Pro Ile Arg Met Arg   Asp Phe Lys Val Thr   Gly Leu Thr 
    21155                 21160                 21165             


Glu Gly   Leu Glu Tyr Glu Phe   Arg Val Met Ala Ile   Asn Leu Ala 
    21170                 21175                 21180             


Gly Val   Gly Lys Pro Ser Leu   Pro Ser Glu Pro Val   Val Ala Leu 
    21185                 21190                 21195             


Asp Pro   Ile Asp Pro Pro Gly   Lys Pro Glu Val Ile   Asn Ile Thr 
    21200                 21205                 21210             


Arg Asn   Ser Val Thr Leu Ile   Trp Thr Glu Pro Lys   Tyr Asp Gly 
    21215                 21220                 21225             


Gly His   Lys Leu Thr Gly Tyr   Ile Val Glu Lys Arg   Asp Leu Pro 
    21230                 21235                 21240             


Ser Lys   Ser Trp Met Lys Ala   Asn His Val Asn Val   Pro Glu Cys 
    21245                 21250                 21255             


Ala Phe   Thr Val Thr Asp Leu   Val Glu Gly Gly Lys   Tyr Glu Phe 
    21260                 21265                 21270             


Arg Ile   Arg Ala Lys Asn Thr   Ala Gly Ala Ile Ser   Ala Pro Ser 
    21275                 21280                 21285             


Glu Ser   Thr Glu Thr Ile Ile   Cys Lys Asp Glu Tyr   Glu Ala Pro 
    21290                 21295                 21300             


Thr Ile   Val Leu Asp Pro Thr   Ile Lys Asp Gly Leu   Thr Ile Lys 
    21305                 21310                 21315             


Ala Gly   Asp Thr Ile Val Leu   Asn Ala Ile Ser Ile   Leu Gly Lys 
    21320                 21325                 21330             


Pro Leu   Pro Lys Ser Ser Trp   Ser Lys Ala Gly Lys   Asp Ile Arg 
    21335                 21340                 21345             


Pro Ser   Asp Ile Thr Gln Ile   Thr Ser Thr Pro Thr   Ser Ser Met 
    21350                 21355                 21360             


Leu Thr   Ile Lys Tyr Ala Thr   Arg Lys Asp Ala Gly   Glu Tyr Thr 
    21365                 21370                 21375             


Ile Thr   Ala Thr Asn Pro Phe   Gly Thr Lys Val Glu   His Val Lys 
    21380                 21385                 21390             


Val Thr   Val Leu Asp Val Pro   Gly Pro Pro Gly Pro   Val Glu Ile 
    21395                 21400                 21405             


Ser Asn   Val Ser Ala Glu Lys   Ala Thr Leu Thr Trp   Thr Pro Pro 
    21410                 21415                 21420             


Leu Glu   Asp Gly Gly Ser Pro   Ile Lys Ser Tyr Ile   Leu Glu Lys 
    21425                 21430                 21435             


Arg Glu   Thr Ser Arg Leu Leu   Trp Thr Val Val Ser   Glu Asp Ile 
    21440                 21445                 21450             


Gln Ser   Cys Arg His Val Ala   Thr Lys Leu Ile Gln   Gly Asn Glu 
    21455                 21460                 21465             


Tyr Ile   Phe Arg Val Ser Ala   Val Asn His Tyr Gly   Lys Gly Glu 
    21470                 21475                 21480             


Pro Val   Gln Ser Glu Pro Val   Lys Met Val Asp Arg   Phe Gly Pro 
    21485                 21490                 21495             


Pro Gly   Pro Pro Glu Lys Pro   Glu Val Ser Asn Val   Thr Lys Asn 
    21500                 21505                 21510             


Thr Ala   Thr Val Ser Trp Lys   Arg Pro Val Asp Asp   Gly Gly Ser 
    21515                 21520                 21525             


Glu Ile   Thr Gly Tyr His Val   Glu Arg Arg Glu Lys   Lys Ser Leu 
    21530                 21535                 21540             


Arg Trp   Val Arg Ala Ile Lys   Thr Pro Val Ser Asp   Leu Arg Cys 
    21545                 21550                 21555             


Lys Val   Thr Gly Leu Gln Glu   Gly Ser Thr Tyr Glu   Phe Arg Val 
    21560                 21565                 21570             


Ser Ala   Glu Asn Arg Ala Gly   Ile Gly Pro Pro Ser   Glu Ala Ser 
    21575                 21580                 21585             


Asp Ser   Val Leu Met Lys Asp   Ala Ala Tyr Pro Pro   Gly Pro Pro 
    21590                 21595                 21600             


Ser Asn   Pro His Val Thr Asp   Thr Thr Lys Lys Ser   Ala Ser Leu 
    21605                 21610                 21615             


Ala Trp   Gly Lys Pro His Tyr   Asp Gly Gly Leu Glu   Ile Thr Gly 
    21620                 21625                 21630             


Tyr Val   Val Glu His Gln Lys   Val Gly Asp Glu Ala   Trp Ile Lys 
    21635                 21640                 21645             


Asp Thr   Thr Gly Thr Ala Leu   Arg Ile Thr Gln Phe   Val Val Pro 
    21650                 21655                 21660             


Asp Leu   Gln Thr Lys Glu Lys   Tyr Asn Phe Arg Ile   Ser Ala Ile 
    21665                 21670                 21675             


Asn Asp   Ala Gly Val Gly Glu   Pro Ala Val Ile Pro   Asp Val Glu 
    21680                 21685                 21690             


Ile Val   Glu Arg Glu Met Ala   Pro Asp Phe Glu Leu   Asp Ala Glu 
    21695                 21700                 21705             


Leu Arg   Arg Thr Leu Val Val   Arg Ala Gly Leu Ser   Ile Arg Ile 
    21710                 21715                 21720             


Phe Val   Pro Ile Lys Gly Arg   Pro Ala Pro Glu Val   Thr Trp Thr 
    21725                 21730                 21735             


Lys Asp   Asn Ile Asn Leu Lys   Asn Arg Ala Asn Ile   Glu Asn Thr 
    21740                 21745                 21750             


Glu Ser   Phe Thr Leu Leu Ile   Ile Pro Glu Cys Asn   Arg Tyr Asp 
    21755                 21760                 21765             


Thr Gly   Lys Phe Val Met Thr   Ile Glu Asn Pro Ala   Gly Lys Lys 
    21770                 21775                 21780             


Ser Gly   Phe Val Asn Val Arg   Val Leu Asp Thr Pro   Gly Pro Val 
    21785                 21790                 21795             


Leu Asn   Leu Arg Pro Thr Asp   Ile Thr Lys Asp Ser   Val Thr Leu 
    21800                 21805                 21810             


His Trp   Asp Leu Pro Leu Ile   Asp Gly Gly Ser Arg   Ile Thr Asn 
    21815                 21820                 21825             


Tyr Ile   Val Glu Lys Arg Glu   Ala Thr Arg Lys Ser   Tyr Ser Thr 
    21830                 21835                 21840             


Ala Thr   Thr Lys Cys His Lys   Cys Thr Tyr Lys Val   Thr Gly Leu 
    21845                 21850                 21855             


Ser Glu   Gly Cys Glu Tyr Phe   Phe Arg Val Met Ala   Glu Asn Glu 
    21860                 21865                 21870             


Tyr Gly   Ile Gly Glu Pro Thr   Glu Thr Thr Glu Pro   Val Lys Ala 
    21875                 21880                 21885             


Ser Glu   Ala Pro Ser Pro Pro   Asp Ser Leu Asn Ile   Met Asp Ile 
    21890                 21895                 21900             


Thr Lys   Ser Thr Val Ser Leu   Ala Trp Pro Lys Pro   Lys His Asp 
    21905                 21910                 21915             


Gly Gly   Ser Lys Ile Thr Gly   Tyr Val Ile Glu Ala   Gln Arg Lys 
    21920                 21925                 21930             


Gly Ser   Asp Gln Trp Thr His   Ile Thr Thr Val Lys   Gly Leu Glu 
    21935                 21940                 21945             


Cys Val   Val Arg Asn Leu Thr   Glu Gly Glu Glu Tyr   Thr Phe Gln 
    21950                 21955                 21960             


Val Met   Ala Val Asn Ser Ala   Gly Arg Ser Ala Pro   Arg Glu Ser 
    21965                 21970                 21975             


Arg Pro   Val Ile Val Lys Glu   Gln Thr Met Leu Pro   Glu Leu Asp 
    21980                 21985                 21990             


Leu Arg   Gly Ile Tyr Gln Lys   Leu Val Ile Ala Lys   Ala Gly Asp 
    21995                 22000                 22005             


Asn Ile   Lys Val Glu Ile Pro   Val Leu Gly Arg Pro   Lys Pro Thr 
    22010                 22015                 22020             


Val Thr   Trp Lys Lys Gly Asp   Gln Ile Leu Lys Gln   Thr Gln Arg 
    22025                 22030                 22035             


Val Asn   Phe Glu Thr Thr Ala   Thr Ser Thr Ile Leu   Asn Ile Asn 
    22040                 22045                 22050             


Glu Cys   Val Arg Ser Asp Ser   Gly Pro Tyr Pro Leu   Thr Ala Arg 
    22055                 22060                 22065             


Asn Ile   Val Gly Glu Val Gly   Asp Val Ile Thr Ile   Gln Val His 
    22070                 22075                 22080             


Asp Ile   Pro Gly Pro Pro Thr   Gly Pro Ile Lys Phe   Asp Glu Val 
    22085                 22090                 22095             


Ser Ser   Asp Phe Val Thr Phe   Ser Trp Asp Pro Pro   Glu Asn Asp 
    22100                 22105                 22110             


Gly Gly   Val Pro Ile Ser Asn   Tyr Val Val Glu Met   Arg Gln Thr 
    22115                 22120                 22125             


Asp Ser   Thr Thr Trp Val Glu   Leu Ala Thr Thr Val   Ile Arg Thr 
    22130                 22135                 22140             


Thr Tyr   Lys Ala Thr Arg Leu   Thr Thr Gly Leu Glu   Tyr Gln Phe 
    22145                 22150                 22155             


Arg Val   Lys Ala Gln Asn Arg   Tyr Gly Val Gly Pro   Gly Ile Thr 
    22160                 22165                 22170             


Ser Ala   Cys Ile Val Ala Asn   Tyr Pro Phe Lys Val   Pro Gly Pro 
    22175                 22180                 22185             


Pro Gly   Thr Pro Gln Val Thr   Ala Val Thr Lys Asp   Ser Met Thr 
    22190                 22195                 22200             


Ile Ser   Trp His Glu Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu 
    22205                 22210                 22215             


Gly Tyr   His Val Glu Arg Lys   Glu Arg Asn Gly Ile   Leu Trp Gln 
    22220                 22225                 22230             


Thr Val   Ser Lys Ala Leu Val   Pro Gly Asn Ile Phe   Lys Ser Ser 
    22235                 22240                 22245             


Gly Leu   Thr Asp Gly Ile Ala   Tyr Glu Phe Arg Val   Ile Ala Glu 
    22250                 22255                 22260             


Asn Met   Ala Gly Lys Ser Lys   Pro Ser Lys Pro Ser   Glu Pro Met 
    22265                 22270                 22275             


Leu Ala   Leu Asp Pro Ile Asp   Pro Pro Gly Lys Pro   Val Pro Leu 
    22280                 22285                 22290             


Asn Ile   Thr Arg His Thr Val   Thr Leu Lys Trp Ala   Lys Pro Glu 
    22295                 22300                 22305             


Tyr Thr   Gly Gly Phe Lys Ile   Thr Ser Tyr Ile Val   Glu Lys Arg 
    22310                 22315                 22320             


Asp Leu   Pro Asn Gly Arg Trp   Leu Lys Ala Asn Phe   Ser Asn Ile 
    22325                 22330                 22335             


Leu Glu   Asn Glu Phe Thr Val   Ser Gly Leu Thr Glu   Asp Ala Ala 
    22340                 22345                 22350             


Tyr Glu   Phe Arg Val Ile Ala   Lys Asn Ala Ala Gly   Ala Ile Ser 
    22355                 22360                 22365             


Pro Pro   Ser Glu Pro Ser Asp   Ala Ile Thr Cys Arg   Asp Asp Val 
    22370                 22375                 22380             


Glu Ala   Pro Lys Ile Lys Val   Asp Val Lys Phe Lys   Asp Thr Val 
    22385                 22390                 22395             


Ile Leu   Lys Ala Gly Glu Ala   Phe Arg Leu Glu Ala   Asp Val Ser 
    22400                 22405                 22410             


Gly Arg   Pro Pro Pro Thr Met   Glu Trp Ser Lys Asp   Gly Lys Glu 
    22415                 22420                 22425             


Leu Glu   Gly Thr Ala Lys Leu   Glu Ile Lys Ile Ala   Asp Phe Ser 
    22430                 22435                 22440             


Thr Asn   Leu Val Asn Lys Asp   Ser Thr Arg Arg Asp   Ser Gly Ala 
    22445                 22450                 22455             


Tyr Thr   Leu Thr Ala Thr Asn   Pro Gly Gly Phe Ala   Lys His Ile 
    22460                 22465                 22470             


Phe Asn   Val Lys Val Leu Asp   Arg Pro Gly Pro Pro   Glu Gly Pro 
    22475                 22480                 22485             


Leu Ala   Val Thr Glu Val Thr   Ser Glu Lys Cys Val   Leu Ser Trp 
    22490                 22495                 22500             


Phe Pro   Pro Leu Asp Asp Gly   Gly Ala Lys Ile Asp   His Tyr Ile 
    22505                 22510                 22515             


Val Gln   Lys Arg Glu Thr Ser   Arg Leu Ala Trp Thr   Asn Val Ala 
    22520                 22525                 22530             


Ser Glu   Val Gln Val Thr Lys   Leu Lys Val Thr Lys   Leu Leu Lys 
    22535                 22540                 22545             


Gly Asn   Glu Tyr Ile Phe Arg   Val Met Ala Val Asn   Lys Tyr Gly 
    22550                 22555                 22560             


Val Gly   Glu Pro Leu Glu Ser   Glu Pro Val Leu Ala   Val Asn Pro 
    22565                 22570                 22575             


Tyr Gly   Pro Pro Asp Pro Pro   Lys Asn Pro Glu Val   Thr Thr Ile 
    22580                 22585                 22590             


Thr Lys   Asp Ser Met Val Val   Cys Trp Gly His Pro   Asp Ser Asp 
    22595                 22600                 22605             


Gly Gly   Ser Glu Ile Ile Asn   Tyr Ile Val Glu Arg   Arg Asp Lys 
    22610                 22615                 22620             


Ala Gly   Gln Arg Trp Ile Lys   Cys Asn Lys Lys Thr   Leu Thr Asp 
    22625                 22630                 22635             


Leu Arg   Tyr Lys Val Ser Gly   Leu Thr Glu Gly His   Glu Tyr Glu 
    22640                 22645                 22650             


Phe Arg   Ile Met Ala Glu Asn   Ala Ala Gly Ile Ser   Ala Pro Ser 
    22655                 22660                 22665             


Pro Thr   Ser Pro Phe Tyr Lys   Ala Cys Asp Thr Val   Phe Lys Pro 
    22670                 22675                 22680             


Gly Pro   Pro Gly Asn Pro Arg   Val Leu Asp Thr Ser   Arg Ser Ser 
    22685                 22690                 22695             


Ile Ser   Ile Ala Trp Asn Lys   Pro Ile Tyr Asp Gly   Gly Ser Glu 
    22700                 22705                 22710             


Ile Thr   Gly Tyr Met Val Glu   Ile Ala Leu Pro Glu   Glu Asp Glu 
    22715                 22720                 22725             


Trp Gln   Ile Val Thr Pro Pro   Ala Gly Leu Lys Ala   Thr Ser Tyr 
    22730                 22735                 22740             


Thr Ile   Thr Gly Leu Thr Glu   Asn Gln Glu Tyr Lys   Ile Arg Ile 
    22745                 22750                 22755             


Tyr Ala   Met Asn Ser Glu Gly   Leu Gly Glu Pro Ala   Leu Val Pro 
    22760                 22765                 22770             


Gly Thr   Pro Lys Ala Glu Asp   Arg Met Leu Pro Pro   Glu Ile Glu 
    22775                 22780                 22785             


Leu Asp   Ala Asp Leu Arg Lys   Val Val Thr Ile Arg   Ala Cys Cys 
    22790                 22795                 22800             


Thr Leu   Arg Leu Phe Val Pro   Ile Lys Gly Arg Pro   Ala Pro Glu 
    22805                 22810                 22815             


Val Lys   Trp Ala Arg Asp His   Gly Glu Ser Leu Asp   Lys Ala Ser 
    22820                 22825                 22830             


Ile Glu   Ser Thr Ser Ser Tyr   Thr Leu Leu Ile Val   Gly Asn Val 
    22835                 22840                 22845             


Asn Arg   Phe Asp Ser Gly Lys   Tyr Ile Leu Thr Val   Glu Asn Ser 
    22850                 22855                 22860             


Ser Gly   Ser Lys Ser Ala Phe   Val Asn Val Arg Val   Leu Asp Thr 
    22865                 22870                 22875             


Pro Gly   Pro Pro Gln Asp Leu   Lys Val Lys Glu Val   Thr Lys Thr 
    22880                 22885                 22890             


Ser Val   Thr Leu Thr Trp Asp   Pro Pro Leu Leu Asp   Gly Gly Ser 
    22895                 22900                 22905             


Lys Ile   Lys Asn Tyr Ile Val   Glu Lys Arg Glu Ser   Thr Arg Lys 
    22910                 22915                 22920             


Ala Tyr   Ser Thr Val Ala Thr   Asn Cys His Lys Thr   Ser Trp Lys 
    22925                 22930                 22935             


Val Asp   Gln Leu Gln Glu Gly   Cys Ser Tyr Tyr Phe   Arg Val Leu 
    22940                 22945                 22950             


Ala Glu   Asn Glu Tyr Gly Ile   Gly Leu Pro Ala Glu   Thr Ala Glu 
    22955                 22960                 22965             


Ser Val   Lys Ala Ser Glu Arg   Pro Leu Pro Pro Gly   Lys Ile Thr 
    22970                 22975                 22980             


Leu Met   Asp Val Thr Arg Asn   Ser Val Ser Leu Ser   Trp Glu Lys 
    22985                 22990                 22995             


Pro Glu   His Asp Gly Gly Ser   Arg Ile Leu Gly Tyr   Ile Val Glu 
    23000                 23005                 23010             


Met Gln   Thr Lys Gly Ser Asp   Lys Trp Ala Thr Cys   Ala Thr Val 
    23015                 23020                 23025             


Lys Val   Thr Glu Ala Thr Ile   Thr Gly Leu Ile Gln   Gly Glu Glu 
    23030                 23035                 23040             


Tyr Ser   Phe Arg Val Ser Ala   Gln Asn Glu Lys Gly   Ile Ser Asp 
    23045                 23050                 23055             


Pro Arg   Gln Leu Ser Val Pro   Val Ile Ala Lys Asp   Leu Val Ile 
    23060                 23065                 23070             


Pro Pro   Ala Phe Lys Leu Leu   Phe Asn Thr Phe Thr   Val Leu Ala 
    23075                 23080                 23085             


Gly Glu   Asp Leu Lys Val Asp   Val Pro Phe Ile Gly   Arg Pro Thr 
    23090                 23095                 23100             


Pro Ala   Val Thr Trp His Lys   Asp Asn Val Pro Leu   Lys Gln Thr 
    23105                 23110                 23115             


Thr Arg   Val Asn Ala Glu Ser   Thr Glu Asn Asn Ser   Leu Leu Thr 
    23120                 23125                 23130             


Ile Lys   Asp Ala Cys Arg Glu   Asp Val Gly His Tyr   Val Val Lys 
    23135                 23140                 23145             


Leu Thr   Asn Ser Ala Gly Glu   Ala Ile Glu Thr Leu   Asn Val Ile 
    23150                 23155                 23160             


Val Leu   Asp Lys Pro Gly Pro   Pro Thr Gly Pro Val   Lys Met Asp 
    23165                 23170                 23175             


Glu Val   Thr Ala Asp Ser Ile   Thr Leu Ser Trp Gly   Pro Pro Lys 
    23180                 23185                 23190             


Tyr Asp   Gly Gly Ser Ser Ile   Asn Asn Tyr Ile Val   Glu Lys Arg 
    23195                 23200                 23205             


Asp Thr   Ser Thr Thr Thr Trp   Gln Ile Val Ser Ala   Thr Val Ala 
    23210                 23215                 23220             


Arg Thr   Thr Ile Lys Ala Cys   Arg Leu Lys Thr Gly   Cys Glu Tyr 
    23225                 23230                 23235             


Gln Phe   Arg Ile Ala Ala Glu   Asn Arg Tyr Gly Lys   Ser Thr Tyr 
    23240                 23245                 23250             


Leu Asn   Ser Glu Pro Thr Val   Ala Gln Tyr Pro Phe   Lys Val Pro 
    23255                 23260                 23265             


Gly Pro   Pro Gly Thr Pro Val   Val Thr Leu Ser Ser   Arg Asp Ser 
    23270                 23275                 23280             


Met Glu   Val Gln Trp Asn Glu   Pro Ile Ser Asp Gly   Gly Ser Arg 
    23285                 23290                 23295             


Val Ile   Gly Tyr His Leu Glu   Arg Lys Glu Arg Asn   Ser Ile Leu 
    23300                 23305                 23310             


Trp Val   Lys Leu Asn Lys Thr   Pro Ile Pro Gln Thr   Lys Phe Lys 
    23315                 23320                 23325             


Thr Thr   Gly Leu Glu Glu Gly   Val Glu Tyr Glu Phe   Arg Val Ser 
    23330                 23335                 23340             


Ala Glu   Asn Ile Val Gly Ile   Gly Lys Pro Ser Lys   Val Ser Glu 
    23345                 23350                 23355             


Cys Tyr   Val Ala Arg Asp Pro   Cys Asp Pro Pro Gly   Arg Pro Glu 
    23360                 23365                 23370             


Ala Ile   Ile Val Thr Arg Asn   Ser Val Thr Leu Gln   Trp Lys Lys 
    23375                 23380                 23385             


Pro Thr   Tyr Asp Gly Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu 
    23390                 23395                 23400             


Lys Lys   Glu Leu Pro Glu Gly   Arg Trp Met Lys Ala   Ser Phe Thr 
    23405                 23410                 23415             


Asn Ile   Ile Asp Thr His Phe   Glu Val Thr Gly Leu   Val Glu Asp 
    23420                 23425                 23430             


His Arg   Tyr Glu Phe Arg Val   Ile Ala Arg Asn Ala   Ala Gly Val 
    23435                 23440                 23445             


Phe Ser   Glu Pro Ser Glu Ser   Thr Gly Ala Ile Thr   Ala Arg Asp 
    23450                 23455                 23460             


Glu Val   Asp Pro Pro Arg Ile   Ser Met Asp Pro Lys   Tyr Lys Asp 
    23465                 23470                 23475             


Thr Ile   Val Val His Ala Gly   Glu Ser Phe Lys Val   Asp Ala Asp 
    23480                 23485                 23490             


Ile Tyr   Gly Lys Pro Ile Pro   Thr Ile Gln Trp Ile   Lys Gly Asp 
    23495                 23500                 23505             


Gln Glu   Leu Ser Asn Thr Ala   Arg Leu Glu Ile Lys   Ser Thr Asp 
    23510                 23515                 23520             


Phe Ala   Thr Ser Leu Ser Val   Lys Asp Ala Val Arg   Val Asp Ser 
    23525                 23530                 23535             


Gly Asn   Tyr Ile Leu Lys Ala   Lys Asn Val Ala Gly   Glu Arg Ser 
    23540                 23545                 23550             


Val Thr   Val Asn Val Lys Val   Leu Asp Arg Pro Gly   Pro Pro Glu 
    23555                 23560                 23565             


Gly Pro   Val Val Ile Ser Gly   Val Thr Ala Glu Lys   Cys Thr Leu 
    23570                 23575                 23580             


Ala Trp   Lys Pro Pro Leu Gln   Asp Gly Gly Ser Asp   Ile Ile Asn 
    23585                 23590                 23595             


Tyr Ile   Val Glu Arg Arg Glu   Thr Ser Arg Leu Val   Trp Thr Val 
    23600                 23605                 23610             


Val Asp   Ala Asn Val Gln Thr   Leu Ser Cys Lys Val   Thr Lys Leu 
    23615                 23620                 23625             


Leu Glu   Gly Asn Glu Tyr Thr   Phe Arg Ile Met Ala   Val Asn Lys 
    23630                 23635                 23640             


Tyr Gly   Val Gly Glu Pro Leu   Glu Ser Glu Pro Val   Val Ala Lys 
    23645                 23650                 23655             


Asn Pro   Phe Val Val Pro Asp   Ala Pro Lys Ala Pro   Glu Val Thr 
    23660                 23665                 23670             


Thr Val   Thr Lys Asp Ser Met   Ile Val Val Trp Glu   Arg Pro Ala 
    23675                 23680                 23685             


Ser Asp   Gly Gly Ser Glu Ile   Leu Gly Tyr Val Leu   Glu Lys Arg 
    23690                 23695                 23700             


Asp Lys   Glu Gly Ile Arg Trp   Thr Arg Cys His Lys   Arg Leu Ile 
    23705                 23710                 23715             


Gly Glu   Leu Arg Leu Arg Val   Thr Gly Leu Ile Glu   Asn His Asp 
    23720                 23725                 23730             


Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Ala Ala Gly   Leu Ser Glu 
    23735                 23740                 23745             


Pro Ser   Pro Pro Ser Ala Tyr   Gln Lys Ala Cys Asp   Pro Ile Tyr 
    23750                 23755                 23760             


Lys Pro   Gly Pro Pro Asn Asn   Pro Lys Val Ile Asp   Ile Thr Arg 
    23765                 23770                 23775             


Ser Ser   Val Phe Leu Ser Trp   Ser Lys Pro Ile Tyr   Asp Gly Gly 
    23780                 23785                 23790             


Cys Glu   Ile Gln Gly Tyr Ile   Val Glu Lys Cys Asp   Val Ser Val 
    23795                 23800                 23805             


Gly Glu   Trp Thr Met Cys Thr   Pro Pro Thr Gly Ile   Asn Lys Thr 
    23810                 23815                 23820             


Asn Ile   Glu Val Glu Lys Leu   Leu Glu Lys His Glu   Tyr Asn Phe 
    23825                 23830                 23835             


Arg Ile   Cys Ala Ile Asn Lys   Ala Gly Val Gly Glu   His Ala Asp 
    23840                 23845                 23850             


Val Pro   Gly Pro Ile Ile Val   Glu Glu Lys Leu Glu   Ala Pro Asp 
    23855                 23860                 23865             


Ile Asp   Leu Asp Leu Glu Leu   Arg Lys Ile Ile Asn   Ile Arg Ala 
    23870                 23875                 23880             


Gly Gly   Ser Leu Arg Leu Phe   Val Pro Ile Lys Gly   Arg Pro Thr 
    23885                 23890                 23895             


Pro Glu   Val Lys Trp Gly Lys   Val Asp Gly Glu Ile   Arg Asp Ala 
    23900                 23905                 23910             


Ala Ile   Ile Asp Val Thr Ser   Ser Phe Thr Ser Leu   Val Leu Asp 
    23915                 23920                 23925             


Asn Val   Asn Arg Tyr Asp Ser   Gly Lys Tyr Thr Leu   Thr Leu Glu 
    23930                 23935                 23940             


Asn Ser   Ser Gly Thr Lys Ser   Ala Phe Val Thr Val   Arg Val Leu 
    23945                 23950                 23955             


Asp Thr   Pro Ser Pro Pro Val   Asn Leu Lys Val Thr   Glu Ile Thr 
    23960                 23965                 23970             


Lys Asp   Ser Val Ser Ile Thr   Trp Glu Pro Pro Leu   Leu Asp Gly 
    23975                 23980                 23985             


Gly Ser   Lys Ile Lys Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Thr 
    23990                 23995                 24000             


Arg Lys   Ser Tyr Ala Ala Val   Val Thr Asn Cys His   Lys Asn Ser 
    24005                 24010                 24015             


Trp Lys   Ile Asp Gln Leu Gln   Glu Gly Cys Ser Tyr   Tyr Phe Arg 
    24020                 24025                 24030             


Val Thr   Ala Glu Asn Glu Tyr   Gly Ile Gly Leu Pro   Ala Gln Thr 
    24035                 24040                 24045             


Ala Asp   Pro Ile Lys Val Ala   Glu Val Pro Gln Pro   Pro Gly Lys 
    24050                 24055                 24060             


Ile Thr   Val Asp Asp Val Thr   Arg Asn Ser Val Ser   Leu Ser Trp 
    24065                 24070                 24075             


Thr Lys   Pro Glu His Asp Gly   Gly Ser Lys Ile Ile   Gln Tyr Ile 
    24080                 24085                 24090             


Val Glu   Met Gln Ala Lys His   Ser Glu Lys Trp Ser   Glu Cys Ala 
    24095                 24100                 24105             


Arg Val   Lys Ser Leu Gln Ala   Val Ile Thr Asn Leu   Thr Gln Gly 
    24110                 24115                 24120             


Glu Glu   Tyr Leu Phe Arg Val   Val Ala Val Asn Glu   Lys Gly Arg 
    24125                 24130                 24135             


Ser Asp   Pro Arg Ser Leu Ala   Val Pro Ile Val Ala   Lys Asp Leu 
    24140                 24145                 24150             


Val Ile   Glu Pro Asp Val Lys   Pro Ala Phe Ser Ser   Tyr Ser Val 
    24155                 24160                 24165             


Gln Val   Gly Gln Asp Leu Lys   Ile Glu Val Pro Ile   Ser Gly Arg 
    24170                 24175                 24180             


Pro Lys   Pro Thr Ile Thr Trp   Thr Lys Asp Gly Leu   Pro Leu Lys 
    24185                 24190                 24195             


Gln Thr   Thr Arg Ile Asn Val   Thr Asp Ser Leu Asp   Leu Thr Thr 
    24200                 24205                 24210             


Leu Ser   Ile Lys Glu Thr His   Lys Asp Asp Gly Gly   Gln Tyr Gly 
    24215                 24220                 24225             


Ile Thr   Val Ala Asn Val Val   Gly Gln Lys Thr Ala   Ser Ile Glu 
    24230                 24235                 24240             


Ile Val   Thr Leu Asp Lys Pro   Asp Pro Pro Lys Gly   Pro Val Lys 
    24245                 24250                 24255             


Phe Asp   Asp Val Ser Ala Glu   Ser Ile Thr Leu Ser   Trp Asn Pro 
    24260                 24265                 24270             


Pro Leu   Tyr Thr Gly Gly Cys   Gln Ile Thr Asn Tyr   Ile Val Gln 
    24275                 24280                 24285             


Lys Arg   Asp Thr Thr Thr Thr   Val Trp Asp Val Val   Ser Ala Thr 
    24290                 24295                 24300             


Val Ala   Arg Thr Thr Leu Lys   Val Thr Lys Leu Lys   Thr Gly Thr 
    24305                 24310                 24315             


Glu Tyr   Gln Phe Arg Ile Phe   Ala Glu Asn Arg Tyr   Gly Gln Ser 
    24320                 24325                 24330             


Phe Ala   Leu Glu Ser Asp Pro   Ile Val Ala Gln Tyr   Pro Tyr Lys 
    24335                 24340                 24345             


Glu Pro   Gly Pro Pro Gly Thr   Pro Phe Ala Thr Ala   Ile Ser Lys 
    24350                 24355                 24360             


Asp Ser   Met Val Ile Gln Trp   His Glu Pro Val Asn   Asn Gly Gly 
    24365                 24370                 24375             


Ser Pro   Val Ile Gly Tyr His   Leu Glu Arg Lys Glu   Arg Asn Ser 
    24380                 24385                 24390             


Ile Leu   Trp Thr Lys Val Asn   Lys Thr Ile Ile His   Asp Thr Gln 
    24395                 24400                 24405             


Phe Lys   Ala Gln Asn Leu Glu   Glu Gly Ile Glu Tyr   Glu Phe Arg 
    24410                 24415                 24420             


Val Tyr   Ala Glu Asn Ile Val   Gly Val Gly Lys Ala   Ser Lys Asn 
    24425                 24430                 24435             


Ser Glu   Cys Tyr Val Ala Arg   Asp Pro Cys Asp Pro   Pro Gly Thr 
    24440                 24445                 24450             


Pro Glu   Pro Ile Met Val Lys   Arg Asn Glu Ile Thr   Leu Gln Trp 
    24455                 24460                 24465             


Thr Lys   Pro Val Tyr Asp Gly   Gly Ser Met Ile Thr   Gly Tyr Ile 
    24470                 24475                 24480             


Val Glu   Lys Arg Asp Leu Pro   Asp Gly Arg Trp Met   Lys Ala Ser 
    24485                 24490                 24495             


Phe Thr   Asn Val Ile Glu Thr   Gln Phe Thr Val Ser   Gly Leu Thr 
    24500                 24505                 24510             


Glu Asp   Gln Arg Tyr Glu Phe   Arg Val Ile Ala Lys   Asn Ala Ala 
    24515                 24520                 24525             


Gly Ala   Ile Ser Lys Pro Ser   Asp Ser Thr Gly Pro   Ile Thr Ala 
    24530                 24535                 24540             


Lys Asp   Glu Val Glu Leu Pro   Arg Ile Ser Met Asp   Pro Lys Phe 
    24545                 24550                 24555             


Arg Asp   Thr Ile Val Val Asn   Ala Gly Glu Thr Phe   Arg Leu Glu 
    24560                 24565                 24570             


Ala Asp   Val His Gly Lys Pro   Leu Pro Thr Ile Glu   Trp Leu Arg 
    24575                 24580                 24585             


Gly Asp   Lys Glu Ile Glu Glu   Ser Ala Arg Cys Glu   Ile Lys Asn 
    24590                 24595                 24600             


Thr Asp   Phe Lys Ala Leu Leu   Ile Val Lys Asp Ala   Ile Arg Ile 
    24605                 24610                 24615             


Asp Gly   Gly Gln Tyr Ile Leu   Arg Ala Ser Asn Val   Ala Gly Ser 
    24620                 24625                 24630             


Lys Ser   Phe Pro Val Asn Val   Lys Val Leu Asp Arg   Pro Gly Pro 
    24635                 24640                 24645             


Pro Glu   Gly Pro Val Gln Val   Thr Gly Val Thr Ser   Glu Lys Cys 
    24650                 24655                 24660             


Ser Leu   Thr Trp Ser Pro Pro   Leu Gln Asp Gly Gly   Ser Asp Ile 
    24665                 24670                 24675             


Ser His   Tyr Val Val Glu Lys   Arg Glu Thr Ser Arg   Leu Ala Trp 
    24680                 24685                 24690             


Thr Val   Val Ala Ser Glu Val   Val Thr Asn Ser Leu   Lys Val Thr 
    24695                 24700                 24705             


Lys Leu   Leu Glu Gly Asn Glu   Tyr Val Phe Arg Ile   Met Ala Val 
    24710                 24715                 24720             


Asn Lys   Tyr Gly Val Gly Glu   Pro Leu Glu Ser Ala   Pro Val Leu 
    24725                 24730                 24735             


Met Lys   Asn Pro Phe Val Leu   Pro Gly Pro Pro Lys   Ser Leu Glu 
    24740                 24745                 24750             


Val Thr   Asn Ile Ala Lys Asp   Ser Met Thr Val Cys   Trp Asn Arg 
    24755                 24760                 24765             


Pro Asp   Ser Asp Gly Gly Ser   Glu Ile Ile Gly Tyr   Ile Val Glu 
    24770                 24775                 24780             


Lys Arg   Asp Arg Ser Gly Ile   Arg Trp Ile Lys Cys   Asn Lys Arg 
    24785                 24790                 24795             


Arg Ile   Thr Asp Leu Arg Leu   Arg Val Thr Gly Leu   Thr Glu Asp 
    24800                 24805                 24810             


His Glu   Tyr Glu Phe Arg Val   Ser Ala Glu Asn Ala   Ala Gly Val 
    24815                 24820                 24825             


Gly Glu   Pro Ser Pro Ala Thr   Val Tyr Tyr Lys Ala   Cys Asp Pro 
    24830                 24835                 24840             


Val Phe   Lys Pro Gly Pro Pro   Thr Asn Ala His Ile   Val Asp Thr 
    24845                 24850                 24855             


Thr Lys   Asn Ser Ile Thr Leu   Ala Trp Gly Lys Pro   Ile Tyr Asp 
    24860                 24865                 24870             


Gly Gly   Ser Glu Ile Leu Gly   Tyr Val Val Glu Ile   Cys Lys Ala 
    24875                 24880                 24885             


Asp Glu   Glu Glu Trp Gln Ile   Val Thr Pro Gln Thr   Gly Leu Arg 
    24890                 24895                 24900             


Val Thr   Arg Phe Glu Ile Ser   Lys Leu Thr Glu His   Gln Glu Tyr 
    24905                 24910                 24915             


Lys Ile   Arg Val Cys Ala Leu   Asn Lys Val Gly Leu   Gly Glu Ala 
    24920                 24925                 24930             


Thr Ser   Val Pro Gly Thr Val   Lys Pro Glu Asp Lys   Leu Glu Ala 
    24935                 24940                 24945             


Pro Glu   Leu Asp Leu Asp Ser   Glu Leu Arg Lys Gly   Ile Val Val 
    24950                 24955                 24960             


Arg Ala   Gly Gly Ser Ala Arg   Ile His Ile Pro Phe   Lys Gly Arg 
    24965                 24970                 24975             


Pro Thr   Pro Glu Ile Thr Trp   Ser Arg Glu Glu Gly   Glu Phe Thr 
    24980                 24985                 24990             


Asp Lys   Val Gln Ile Glu Lys   Gly Val Asn Tyr Thr   Gln Leu Ser 
    24995                 25000                 25005             


Ile Asp   Asn Cys Asp Arg Asn   Asp Ala Gly Lys Tyr   Ile Leu Lys 
    25010                 25015                 25020             


Leu Glu   Asn Ser Ser Gly Ser   Lys Ser Ala Phe Val   Thr Val Lys 
    25025                 25030                 25035             


Val Leu   Asp Thr Pro Gly Pro   Pro Gln Asn Leu Ala   Val Lys Glu 
    25040                 25045                 25050             


Val Arg   Lys Asp Ser Ala Phe   Leu Val Trp Glu Pro   Pro Ile Ile 
    25055                 25060                 25065             


Asp Gly   Gly Ala Lys Val Lys   Asn Tyr Val Ile Asp   Lys Arg Glu 
    25070                 25075                 25080             


Ser Thr   Arg Lys Ala Tyr Ala   Asn Val Ser Ser Lys   Cys Ser Lys 
    25085                 25090                 25095             


Thr Ser   Phe Lys Val Glu Asn   Leu Thr Glu Gly Ala   Ile Tyr Tyr 
    25100                 25105                 25110             


Phe Arg   Val Met Ala Glu Asn   Glu Phe Gly Val Gly   Val Pro Val 
    25115                 25120                 25125             


Glu Thr   Val Asp Ala Val Lys   Ala Ala Glu Pro Pro   Ser Pro Pro 
    25130                 25135                 25140             


Gly Lys   Val Thr Leu Thr Asp   Val Ser Gln Thr Ser   Ala Ser Leu 
    25145                 25150                 25155             


Met Trp   Glu Lys Pro Glu His   Asp Gly Gly Ser Arg   Val Leu Gly 
    25160                 25165                 25170             


Tyr Val   Val Glu Met Gln Pro   Lys Gly Thr Glu Lys   Trp Ser Ile 
    25175                 25180                 25185             


Val Ala   Glu Ser Lys Val Cys   Asn Ala Val Val Thr   Gly Leu Ser 
    25190                 25195                 25200             


Ser Gly   Gln Glu Tyr Gln Phe   Arg Val Lys Ala Tyr   Asn Glu Lys 
    25205                 25210                 25215             


Gly Lys   Ser Asp Pro Arg Val   Leu Gly Val Pro Val   Ile Ala Lys 
    25220                 25225                 25230             


Asp Leu   Thr Ile Gln Pro Ser   Leu Lys Leu Pro Phe   Asn Thr Tyr 
    25235                 25240                 25245             


Ser Ile   Gln Ala Gly Glu Asp   Leu Lys Ile Glu Ile   Pro Val Ile 
    25250                 25255                 25260             


Gly Arg   Pro Arg Pro Asn Ile   Ser Trp Val Lys Asp   Gly Glu Pro 
    25265                 25270                 25275             


Leu Lys   Gln Thr Thr Arg Val   Asn Val Glu Glu Thr   Ala Thr Ser 
    25280                 25285                 25290             


Thr Val   Leu His Ile Lys Glu   Gly Asn Lys Asp Asp   Phe Gly Lys 
    25295                 25300                 25305             


Tyr Thr   Val Thr Ala Thr Asn   Ser Ala Gly Thr Ala   Thr Glu Asn 
    25310                 25315                 25320             


Leu Ser   Val Ile Val Leu Glu   Lys Pro Gly Pro Pro   Val Gly Pro 
    25325                 25330                 25335             


Val Arg   Phe Asp Glu Val Ser   Ala Asp Phe Val Val   Ile Ser Trp 
    25340                 25345                 25350             


Glu Pro   Pro Ala Tyr Thr Gly   Gly Cys Gln Ile Ser   Asn Tyr Ile 
    25355                 25360                 25365             


Val Glu   Lys Arg Asp Thr Thr   Thr Thr Thr Trp His   Met Val Ser 
    25370                 25375                 25380             


Ala Thr   Val Ala Arg Thr Thr   Ile Lys Ile Thr Lys   Leu Lys Thr 
    25385                 25390                 25395             


Gly Thr   Glu Tyr Gln Phe Arg   Ile Phe Ala Glu Asn   Arg Tyr Gly 
    25400                 25405                 25410             


Lys Ser   Ala Pro Leu Asp Ser   Lys Ala Val Ile Val   Gln Tyr Pro 
    25415                 25420                 25425             


Phe Lys   Glu Pro Gly Pro Pro   Gly Thr Pro Phe Val   Thr Ser Ile 
    25430                 25435                 25440             


Ser Lys   Asp Gln Met Leu Val   Gln Trp His Glu Pro   Val Asn Asp 
    25445                 25450                 25455             


Gly Gly   Thr Lys Ile Ile Gly   Tyr His Leu Glu Gln   Lys Glu Lys 
    25460                 25465                 25470             


Asn Ser   Ile Leu Trp Val Lys   Leu Asn Lys Thr Pro   Ile Gln Asp 
    25475                 25480                 25485             


Thr Lys   Phe Lys Thr Thr Gly   Leu Asp Glu Gly Leu   Glu Tyr Glu 
    25490                 25495                 25500             


Phe Lys   Val Ser Ala Glu Asn   Ile Val Gly Ile Gly   Lys Pro Ser 
    25505                 25510                 25515             


Lys Val   Ser Glu Cys Phe Val   Ala Arg Asp Pro Cys   Asp Pro Pro 
    25520                 25525                 25530             


Gly Arg   Pro Glu Ala Ile Val   Ile Thr Arg Asn Asn   Val Thr Leu 
    25535                 25540                 25545             


Lys Trp   Lys Lys Pro Ala Tyr   Asp Gly Gly Ser Lys   Ile Thr Gly 
    25550                 25555                 25560             


Tyr Ile   Val Glu Lys Lys Asp   Leu Pro Asp Gly Arg   Trp Met Lys 
    25565                 25570                 25575             


Ala Ser   Phe Thr Asn Val Leu   Glu Thr Glu Phe Thr   Val Ser Gly 
    25580                 25585                 25590             


Leu Val   Glu Asp Gln Arg Tyr   Glu Phe Arg Val Ile   Ala Arg Asn 
    25595                 25600                 25605             


Ala Ala   Gly Asn Phe Ser Glu   Pro Ser Asp Ser Ser   Gly Ala Ile 
    25610                 25615                 25620             


Thr Ala   Arg Asp Glu Ile Asp   Ala Pro Asn Ala Ser   Leu Asp Pro 
    25625                 25630                 25635             


Lys Tyr   Lys Asp Val Ile Val   Val His Ala Gly Glu   Thr Phe Val 
    25640                 25645                 25650             


Leu Glu   Ala Asp Ile Arg Gly   Lys Pro Ile Pro Asp   Val Val Trp 
    25655                 25660                 25665             


Ser Lys   Asp Gly Lys Glu Leu   Glu Glu Thr Ala Ala   Arg Met Glu 
    25670                 25675                 25680             


Ile Lys   Ser Thr Ile Gln Lys   Thr Thr Leu Val Val   Lys Asp Cys 
    25685                 25690                 25695             


Ile Arg   Thr Asp Gly Gly Gln   Tyr Ile Leu Lys Leu   Ser Asn Val 
    25700                 25705                 25710             


Gly Gly   Thr Lys Ser Ile Pro   Ile Thr Val Lys Val   Leu Asp Arg 
    25715                 25720                 25725             


Pro Gly   Pro Pro Glu Gly Pro   Leu Lys Val Thr Gly   Val Thr Ala 
    25730                 25735                 25740             


Glu Lys   Cys Tyr Leu Ala Trp   Asn Pro Pro Leu Gln   Asp Gly Gly 
    25745                 25750                 25755             


Ala Asn   Ile Ser His Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg 
    25760                 25765                 25770             


Leu Ser   Trp Thr Gln Val Ser   Thr Glu Val Gln Ala   Leu Asn Tyr 
    25775                 25780                 25785             


Lys Val   Thr Lys Leu Leu Pro   Gly Asn Glu Tyr Ile   Phe Arg Val 
    25790                 25795                 25800             


Met Ala   Val Asn Lys Tyr Gly   Ile Gly Glu Pro Leu   Glu Ser Gly 
    25805                 25810                 25815             


Pro Val   Thr Ala Cys Asn Pro   Tyr Lys Pro Pro Gly   Pro Pro Ser 
    25820                 25825                 25830             


Thr Pro   Glu Val Ser Ala Ile   Thr Lys Asp Ser Met   Val Val Thr 
    25835                 25840                 25845             


Trp Ala   Arg Pro Val Asp Asp   Gly Gly Thr Glu Ile   Glu Gly Tyr 
    25850                 25855                 25860             


Ile Leu   Glu Lys Arg Asp Lys   Glu Gly Val Arg Trp   Thr Lys Cys 
    25865                 25870                 25875             


Asn Lys   Lys Thr Leu Thr Asp   Leu Arg Leu Arg Val   Thr Gly Leu 
    25880                 25885                 25890             


Thr Glu   Gly His Ser Tyr Glu   Phe Arg Val Ala Ala   Glu Asn Ala 
    25895                 25900                 25905             


Ala Gly   Val Gly Glu Pro Ser   Glu Pro Ser Val Phe   Tyr Arg Ala 
    25910                 25915                 25920             


Cys Asp   Ala Leu Tyr Pro Pro   Gly Pro Pro Ser Asn   Pro Lys Val 
    25925                 25930                 25935             


Thr Asp   Thr Ser Arg Ser Ser   Val Ser Leu Ala Trp   Ser Lys Pro 
    25940                 25945                 25950             


Ile Tyr   Asp Gly Gly Ala Pro   Val Lys Gly Tyr Val   Val Glu Val 
    25955                 25960                 25965             


Lys Glu   Ala Ala Ala Asp Glu   Trp Thr Thr Cys Thr   Pro Pro Thr 
    25970                 25975                 25980             


Gly Leu   Gln Gly Lys Gln Phe   Thr Val Thr Lys Leu   Lys Glu Asn 
    25985                 25990                 25995             


Thr Glu   Tyr Asn Phe Arg Ile   Cys Ala Ile Asn Ser   Glu Gly Val 
    26000                 26005                 26010             


Gly Glu   Pro Ala Thr Leu Pro   Gly Ser Val Val Ala   Gln Glu Arg 
    26015                 26020                 26025             


Ile Glu   Pro Pro Glu Ile Glu   Leu Asp Ala Asp Leu   Arg Lys Val 
    26030                 26035                 26040             


Val Val   Leu Arg Ala Ser Ala   Thr Leu Arg Leu Phe   Val Thr Ile 
    26045                 26050                 26055             


Lys Gly   Arg Pro Glu Pro Glu   Val Lys Trp Glu Lys   Ala Glu Gly 
    26060                 26065                 26070             


Ile Leu   Thr Asp Arg Ala Gln   Ile Glu Val Thr Ser   Ser Phe Thr 
    26075                 26080                 26085             


Met Leu   Val Ile Asp Asn Val   Thr Arg Phe Asp Ser   Gly Arg Tyr 
    26090                 26095                 26100             


Asn Leu   Thr Leu Glu Asn Asn   Ser Gly Ser Lys Thr   Ala Phe Val 
    26105                 26110                 26115             


Asn Val   Arg Val Leu Asp Ser   Pro Ser Ala Pro Val   Asn Leu Thr 
    26120                 26125                 26130             


Ile Arg   Glu Val Lys Lys Asp   Ser Val Thr Leu Ser   Trp Glu Pro 
    26135                 26140                 26145             


Pro Leu   Ile Asp Gly Gly Ala   Lys Ile Thr Asn Tyr   Ile Val Glu 
    26150                 26155                 26160             


Lys Arg   Glu Thr Thr Arg Lys   Ala Tyr Ala Thr Ile   Thr Asn Asn 
    26165                 26170                 26175             


Cys Thr   Lys Thr Thr Phe Arg   Ile Glu Asn Leu Gln   Glu Gly Cys 
    26180                 26185                 26190             


Ser Tyr   Tyr Phe Arg Val Leu   Ala Ser Asn Glu Tyr   Gly Ile Gly 
    26195                 26200                 26205             


Leu Pro   Ala Glu Thr Thr Glu   Pro Val Lys Val Ser   Glu Pro Pro 
    26210                 26215                 26220             


Leu Pro   Pro Gly Arg Val Thr   Leu Val Asp Val Thr   Arg Asn Thr 
    26225                 26230                 26235             


Ala Thr   Ile Lys Trp Glu Lys   Pro Glu Ser Asp Gly   Gly Ser Lys 
    26240                 26245                 26250             


Ile Thr   Gly Tyr Val Val Glu   Met Gln Thr Lys Gly   Ser Glu Lys 
    26255                 26260                 26265             


Trp Ser   Thr Cys Thr Gln Val   Lys Thr Leu Glu Ala   Thr Ile Ser 
    26270                 26275                 26280             


Gly Leu   Thr Ala Gly Glu Glu   Tyr Val Phe Arg Val   Ala Ala Val 
    26285                 26290                 26295             


Asn Glu   Lys Gly Arg Ser Asp   Pro Arg Gln Leu Gly   Val Pro Val 
    26300                 26305                 26310             


Ile Ala   Arg Asp Ile Glu Ile   Lys Pro Ser Val Glu   Leu Pro Phe 
    26315                 26320                 26325             


His Thr   Phe Asn Val Lys Ala   Arg Glu Gln Leu Lys   Ile Asp Val 
    26330                 26335                 26340             


Pro Phe   Lys Gly Arg Pro Gln   Ala Thr Val Asn Trp   Arg Lys Asp 
    26345                 26350                 26355             


Gly Gln   Thr Leu Lys Glu Thr   Thr Arg Val Asn Val   Ser Ser Ser 
    26360                 26365                 26370             


Lys Thr   Val Thr Ser Leu Ser   Ile Lys Glu Ala Ser   Lys Glu Asp 
    26375                 26380                 26385             


Val Gly   Thr Tyr Glu Leu Cys   Val Ser Asn Ser Ala   Gly Ser Ile 
    26390                 26395                 26400             


Thr Val   Pro Ile Thr Ile Ile   Val Leu Asp Arg Pro   Gly Pro Pro 
    26405                 26410                 26415             


Gly Pro   Ile Arg Ile Asp Glu   Val Ser Cys Asp Ser   Ile Thr Ile 
    26420                 26425                 26430             


Ser Trp   Asn Pro Pro Glu Tyr   Asp Gly Gly Cys Gln   Ile Ser Asn 
    26435                 26440                 26445             


Tyr Ile   Val Glu Lys Lys Glu   Thr Thr Ser Thr Thr   Trp His Ile 
    26450                 26455                 26460             


Val Ser   Gln Ala Val Ala Arg   Thr Ser Ile Lys Ile   Val Arg Leu 
    26465                 26470                 26475             


Thr Thr   Gly Ser Glu Tyr Gln   Phe Arg Val Cys Ala   Glu Asn Arg 
    26480                 26485                 26490             


Tyr Gly   Lys Ser Ser Tyr Ser   Glu Ser Ser Ala Val   Val Ala Glu 
    26495                 26500                 26505             


Tyr Pro   Phe Ser Pro Pro Gly   Pro Pro Gly Thr Pro   Lys Val Val 
    26510                 26515                 26520             


His Ala   Thr Lys Ser Thr Met   Leu Val Thr Trp Gln   Val Pro Val 
    26525                 26530                 26535             


Asn Asp   Gly Gly Ser Arg Val   Ile Gly Tyr His Leu   Glu Tyr Lys 
    26540                 26545                 26550             


Glu Arg   Ser Ser Ile Leu Trp   Ser Lys Ala Asn Lys   Ile Leu Ile 
    26555                 26560                 26565             


Ala Asp   Thr Gln Met Lys Val   Ser Gly Leu Asp Glu   Gly Leu Met 
    26570                 26575                 26580             


Tyr Glu   Tyr Arg Val Tyr Ala   Glu Asn Ile Ala Gly   Ile Gly Lys 
    26585                 26590                 26595             


Cys Ser   Lys Ser Cys Glu Pro   Val Pro Ala Arg Asp   Pro Cys Asp 
    26600                 26605                 26610             


Pro Pro   Gly Gln Pro Glu Val   Thr Asn Ile Thr Arg   Lys Ser Val 
    26615                 26620                 26625             


Ser Leu   Lys Trp Ser Lys Pro   His Tyr Asp Gly Gly   Ala Lys Ile 
    26630                 26635                 26640             


Thr Gly   Tyr Ile Val Glu Arg   Arg Glu Leu Pro Asp   Gly Arg Trp 
    26645                 26650                 26655             


Leu Lys   Cys Asn Tyr Thr Asn   Ile Gln Glu Thr Tyr   Phe Glu Val 
    26660                 26665                 26670             


Thr Glu   Leu Thr Glu Asp Gln   Arg Tyr Glu Phe Arg   Val Phe Ala 
    26675                 26680                 26685             


Arg Asn   Ala Ala Asp Ser Val   Ser Glu Pro Ser Glu   Ser Thr Gly 
    26690                 26695                 26700             


Pro Ile   Ile Val Lys Asp Asp   Val Glu Pro Pro Arg   Val Met Met 
    26705                 26710                 26715             


Asp Val   Lys Phe Arg Asp Val   Ile Val Val Lys Ala   Gly Glu Val 
    26720                 26725                 26730             


Leu Lys   Ile Asn Ala Asp Ile   Ala Gly Arg Pro Leu   Pro Val Ile 
    26735                 26740                 26745             


Ser Trp   Ala Lys Asp Gly Ile   Glu Ile Glu Glu Arg   Ala Arg Thr 
    26750                 26755                 26760             


Glu Ile   Ile Ser Thr Asp Asn   His Thr Leu Leu Thr   Val Lys Asp 
    26765                 26770                 26775             


Cys Ile   Arg Arg Asp Thr Gly   Gln Tyr Val Leu Thr   Leu Lys Asn 
    26780                 26785                 26790             


Val Ala   Gly Thr Arg Ser Val   Ala Val Asn Cys Lys   Val Leu Asp 
    26795                 26800                 26805             


Lys Pro   Gly Pro Pro Ala Gly   Pro Leu Glu Ile Asn   Gly Leu Thr 
    26810                 26815                 26820             


Ala Glu   Lys Cys Ser Leu Ser   Trp Gly Arg Pro Gln   Glu Asp Gly 
    26825                 26830                 26835             


Gly Ala   Asp Ile Asp Tyr Tyr   Ile Val Glu Lys Arg   Glu Thr Ser 
    26840                 26845                 26850             


His Leu   Ala Trp Thr Ile Cys   Glu Gly Glu Leu Gln   Met Thr Ser 
    26855                 26860                 26865             


Cys Lys   Val Thr Lys Leu Leu   Lys Gly Asn Glu Tyr   Ile Phe Arg 
    26870                 26875                 26880             


Val Thr   Gly Val Asn Lys Tyr   Gly Val Gly Glu Pro   Leu Glu Ser 
    26885                 26890                 26895             


Val Ala   Ile Lys Ala Leu Asp   Pro Phe Thr Val Pro   Ser Pro Pro 
    26900                 26905                 26910             


Thr Ser   Leu Glu Ile Thr Ser   Val Thr Lys Glu Ser   Met Thr Leu 
    26915                 26920                 26925             


Cys Trp   Ser Arg Pro Glu Ser   Asp Gly Gly Ser Glu   Ile Ser Gly 
    26930                 26935                 26940             


Tyr Ile   Ile Glu Arg Arg Glu   Lys Asn Ser Leu Arg   Trp Val Arg 
    26945                 26950                 26955             


Val Asn   Lys Lys Pro Val Tyr   Asp Leu Arg Val Lys   Ser Thr Gly 
    26960                 26965                 26970             


Leu Arg   Glu Gly Cys Glu Tyr   Glu Tyr Arg Val Tyr   Ala Glu Asn 
    26975                 26980                 26985             


Ala Ala   Gly Leu Ser Leu Pro   Ser Glu Thr Ser Pro   Leu Ile Arg 
    26990                 26995                 27000             


Ala Glu   Asp Pro Val Phe Leu   Pro Ser Pro Pro Ser   Lys Pro Lys 
    27005                 27010                 27015             


Ile Val   Asp Ser Gly Lys Thr   Thr Ile Thr Ile Ala   Trp Val Lys 
    27020                 27025                 27030             


Pro Leu   Phe Asp Gly Gly Ala   Pro Ile Thr Gly Tyr   Thr Val Glu 
    27035                 27040                 27045             


Tyr Lys   Lys Ser Asp Asp Thr   Asp Trp Lys Thr Ser   Ile Gln Ser 
    27050                 27055                 27060             


Leu Arg   Gly Thr Glu Tyr Thr   Ile Ser Gly Leu Thr   Thr Gly Ala 
    27065                 27070                 27075             


Glu Tyr   Val Phe Arg Val Lys   Ser Val Asn Lys Val   Gly Ala Ser 
    27080                 27085                 27090             


Asp Pro   Ser Asp Ser Ser Asp   Pro Gln Ile Ala Lys   Glu Arg Glu 
    27095                 27100                 27105             


Glu Glu   Pro Leu Phe Asp Ile   Asp Ser Glu Met Arg   Lys Thr Leu 
    27110                 27115                 27120             


Ile Val   Lys Ala Gly Ala Ser   Phe Thr Met Thr Val   Pro Phe Arg 
    27125                 27130                 27135             


Gly Arg   Pro Val Pro Asn Val   Leu Trp Ser Lys Pro   Asp Thr Asp 
    27140                 27145                 27150             


Leu Arg   Thr Arg Ala Tyr Val   Asp Thr Thr Asp Ser   Arg Thr Ser 
    27155                 27160                 27165             


Leu Thr   Ile Glu Asn Ala Asn   Arg Asn Asp Ser Gly   Lys Tyr Thr 
    27170                 27175                 27180             


Leu Thr   Ile Gln Asn Val Leu   Ser Ala Ala Ser Leu   Thr Leu Val 
    27185                 27190                 27195             


Val Lys   Val Leu Asp Thr Pro   Gly Pro Pro Thr Asn   Ile Thr Val 
    27200                 27205                 27210             


Gln Asp   Val Thr Lys Glu Ser   Ala Val Leu Ser Trp   Asp Val Pro 
    27215                 27220                 27225             


Glu Asn   Asp Gly Gly Ala Pro   Val Lys Asn Tyr His   Ile Glu Lys 
    27230                 27235                 27240             


Arg Glu   Ala Ser Lys Lys Ala   Trp Val Ser Val Thr   Asn Asn Cys 
    27245                 27250                 27255             


Asn Arg   Leu Ser Tyr Lys Val   Thr Asn Leu Gln Glu   Gly Ala Ile 
    27260                 27265                 27270             


Tyr Tyr   Phe Arg Val Ser Gly   Glu Asn Glu Phe Gly   Val Gly Ile 
    27275                 27280                 27285             


Pro Ala   Glu Thr Lys Glu Gly   Val Lys Ile Thr Glu   Lys Pro Ser 
    27290                 27295                 27300             


Pro Pro   Glu Lys Leu Gly Val   Thr Ser Ile Ser Lys   Asp Ser Val 
    27305                 27310                 27315             


Ser Leu   Thr Trp Leu Lys Pro   Glu His Asp Gly Gly   Ser Arg Ile 
    27320                 27325                 27330             


Val His   Tyr Val Val Glu Ala   Leu Glu Lys Gly Gln   Lys Asn Trp 
    27335                 27340                 27345             


Val Lys   Cys Ala Val Ala Lys   Ser Thr His His Val   Val Ser Gly 
    27350                 27355                 27360             


Leu Arg   Glu Asn Ser Glu Tyr   Phe Phe Arg Val Phe   Ala Glu Asn 
    27365                 27370                 27375             


Gln Ala   Gly Leu Ser Asp Pro   Arg Glu Leu Leu Leu   Pro Val Leu 
    27380                 27385                 27390             


Ile Lys   Glu Gln Leu Glu Pro   Pro Glu Ile Asp Met   Lys Asn Phe 
    27395                 27400                 27405             


Pro Ser   His Thr Val Tyr Val   Arg Ala Gly Ser Asn   Leu Lys Val 
    27410                 27415                 27420             


Asp Ile   Pro Ile Ser Gly Lys   Pro Leu Pro Lys Val   Thr Leu Ser 
    27425                 27430                 27435             


Arg Asp   Gly Val Pro Leu Lys   Ala Thr Met Arg Phe   Asn Thr Glu 
    27440                 27445                 27450             


Ile Thr   Ala Glu Asn Leu Thr   Ile Asn Leu Lys Glu   Ser Val Thr 
    27455                 27460                 27465             


Ala Asp   Ala Gly Arg Tyr Glu   Ile Thr Ala Ala Asn   Ser Ser Gly 
    27470                 27475                 27480             


Thr Thr   Lys Ala Phe Ile Asn   Ile Val Val Leu Asp   Arg Pro Gly 
    27485                 27490                 27495             


Pro Pro   Thr Gly Pro Val Val   Ile Ser Asp Ile Thr   Glu Glu Ser 
    27500                 27505                 27510             


Val Thr   Leu Lys Trp Glu Pro   Pro Lys Tyr Asp Gly   Gly Ser Gln 
    27515                 27520                 27525             


Val Thr   Asn Tyr Ile Leu Leu   Lys Arg Glu Thr Ser   Thr Ala Val 
    27530                 27535                 27540             


Trp Thr   Glu Val Ser Ala Thr   Val Ala Arg Thr Met   Met Lys Val 
    27545                 27550                 27555             


Met Lys   Leu Thr Thr Gly Glu   Glu Tyr Gln Phe Arg   Ile Lys Ala 
    27560                 27565                 27570             


Glu Asn   Arg Phe Gly Ile Ser   Asp His Ile Asp Ser   Ala Cys Val 
    27575                 27580                 27585             


Thr Val   Lys Leu Pro Tyr Thr   Thr Pro Gly Pro Pro   Ser Thr Pro 
    27590                 27595                 27600             


Trp Val   Thr Asn Val Thr Arg   Glu Ser Ile Thr Val   Gly Trp His 
    27605                 27610                 27615             


Glu Pro   Val Ser Asn Gly Gly   Ser Ala Val Val Gly   Tyr His Leu 
    27620                 27625                 27630             


Glu Met   Lys Asp Arg Asn Ser   Ile Leu Trp Gln Lys   Ala Asn Lys 
    27635                 27640                 27645             


Leu Val   Ile Arg Thr Thr His   Phe Lys Val Thr Thr   Ile Ser Ala 
    27650                 27655                 27660             


Gly Leu   Ile Tyr Glu Phe Arg   Val Tyr Ala Glu Asn   Ala Ala Gly 
    27665                 27670                 27675             


Val Gly   Lys Pro Ser His Pro   Ser Glu Pro Val Leu   Ala Ile Asp 
    27680                 27685                 27690             


Ala Cys   Glu Pro Pro Arg Asn   Val Arg Ile Thr Asp   Ile Ser Lys 
    27695                 27700                 27705             


Asn Ser   Val Ser Leu Ser Trp   Gln Gln Pro Ala Phe   Asp Gly Gly 
    27710                 27715                 27720             


Ser Lys   Ile Thr Gly Tyr Ile   Val Glu Arg Arg Asp   Leu Pro Asp 
    27725                 27730                 27735             


Gly Arg   Trp Thr Lys Ala Ser   Phe Thr Asn Val Thr   Glu Thr Gln 
    27740                 27745                 27750             


Phe Ile   Ile Ser Gly Leu Thr   Gln Asn Ser Gln Tyr   Glu Phe Arg 
    27755                 27760                 27765             


Val Phe   Ala Arg Asn Ala Val   Gly Ser Ile Ser Asn   Pro Ser Glu 
    27770                 27775                 27780             


Val Val   Gly Pro Ile Thr Cys   Ile Asp Ser Tyr Gly   Gly Pro Val 
    27785                 27790                 27795             


Ile Asp   Leu Pro Leu Glu Tyr   Thr Glu Val Val Lys   Tyr Arg Ala 
    27800                 27805                 27810             


Gly Thr   Ser Val Lys Leu Arg   Ala Gly Ile Ser Gly   Lys Pro Ala 
    27815                 27820                 27825             


Pro Thr   Ile Glu Trp Tyr Lys   Asp Asp Lys Glu Leu   Gln Thr Asn 
    27830                 27835                 27840             


Ala Leu   Val Cys Val Glu Asn   Thr Thr Asp Leu Ala   Ser Ile Leu 
    27845                 27850                 27855             


Ile Lys   Asp Ala Asp Arg Leu   Asn Ser Gly Cys Tyr   Glu Leu Lys 
    27860                 27865                 27870             


Leu Arg   Asn Ala Met Gly Ser   Ala Ser Ala Thr Ile   Arg Val Gln 
    27875                 27880                 27885             


Ile Leu   Asp Lys Pro Gly Pro   Pro Gly Gly Pro Ile   Glu Phe Lys 
    27890                 27895                 27900             


Thr Val   Thr Ala Glu Lys Ile   Thr Leu Leu Trp Arg   Pro Pro Ala 
    27905                 27910                 27915             


Asp Asp   Gly Gly Ala Lys Ile   Thr His Tyr Ile Val   Glu Lys Arg 
    27920                 27925                 27930             


Glu Thr   Ser Arg Val Val Trp   Ser Met Val Ser Glu   His Leu Glu 
    27935                 27940                 27945             


Glu Cys   Ile Ile Thr Thr Thr   Lys Ile Ile Lys Gly   Asn Glu Tyr 
    27950                 27955                 27960             


Ile Phe   Arg Val Arg Ala Val   Asn Lys Tyr Gly Ile   Gly Glu Pro 
    27965                 27970                 27975             


Leu Glu   Ser Asp Ser Val Val   Ala Lys Asn Ala Phe   Val Thr Pro 
    27980                 27985                 27990             


Gly Pro   Pro Gly Ile Pro Glu   Val Thr Lys Ile Thr   Lys Asn Ser 
    27995                 28000                 28005             


Met Thr   Val Val Trp Ser Arg   Pro Ile Ala Asp Gly   Gly Ser Asp 
    28010                 28015                 28020             


Ile Ser   Gly Tyr Phe Leu Glu   Lys Arg Asp Lys Lys   Ser Leu Gly 
    28025                 28030                 28035             


Trp Phe   Lys Val Leu Lys Glu   Thr Ile Arg Asp Thr   Arg Gln Lys 
    28040                 28045                 28050             


Val Thr   Gly Leu Thr Glu Asn   Ser Asp Tyr Gln Tyr   Arg Val Cys 
    28055                 28060                 28065             


Ala Val   Asn Ala Ala Gly Gln   Gly Pro Phe Ser Glu   Pro Ser Glu 
    28070                 28075                 28080             


Phe Tyr   Lys Ala Ala Asp Pro   Ile Asp Pro Pro Gly   Pro Pro Ala 
    28085                 28090                 28095             


Lys Ile   Arg Ile Ala Asp Ser   Thr Lys Ser Ser Ile   Thr Leu Gly 
    28100                 28105                 28110             


Trp Ser   Lys Pro Val Tyr Asp   Gly Gly Ser Ala Val   Thr Gly Tyr 
    28115                 28120                 28125             


Val Val   Glu Ile Arg Gln Gly   Glu Glu Glu Glu Trp   Thr Thr Val 
    28130                 28135                 28140             


Ser Thr   Lys Gly Glu Val Arg   Thr Thr Glu Tyr Val   Val Ser Asn 
    28145                 28150                 28155             


Leu Lys   Pro Gly Val Asn Tyr   Tyr Phe Arg Val Ser   Ala Val Asn 
    28160                 28165                 28170             


Cys Ala   Gly Gln Gly Glu Pro   Ile Glu Met Asn Glu   Pro Val Gln 
    28175                 28180                 28185             


Ala Lys   Asp Ile Leu Glu Ala   Pro Glu Ile Asp Leu   Asp Val Ala 
    28190                 28195                 28200             


Leu Arg   Thr Ser Val Ile Ala   Lys Ala Gly Glu Asp   Val Gln Val 
    28205                 28210                 28215             


Leu Ile   Pro Phe Lys Gly Arg   Pro Pro Pro Thr Val   Thr Trp Arg 
    28220                 28225                 28230             


Lys Asp   Glu Lys Asn Leu Gly   Ser Asp Ala Arg Tyr   Ser Ile Glu 
    28235                 28240                 28245             


Asn Thr   Asp Ser Ser Ser Leu   Leu Thr Ile Pro Gln   Val Thr Arg 
    28250                 28255                 28260             


Asn Asp   Thr Gly Lys Tyr Ile   Leu Thr Ile Glu Asn   Gly Val Gly 
    28265                 28270                 28275             


Glu Pro   Lys Ser Ser Thr Val   Ser Val Lys Val Leu   Asp Thr Pro 
    28280                 28285                 28290             


Ala Ala   Cys Gln Lys Leu Gln   Val Lys His Val Ser   Arg Gly Thr 
    28295                 28300                 28305             


Val Thr   Leu Leu Trp Asp Pro   Pro Leu Ile Asp Gly   Gly Ser Pro 
    28310                 28315                 28320             


Ile Ile   Asn Tyr Val Ile Glu   Lys Arg Asp Ala Thr   Lys Arg Thr 
    28325                 28330                 28335             


Trp Ser   Val Val Ser His Lys   Cys Ser Ser Thr Ser   Phe Lys Leu 
    28340                 28345                 28350             


Ile Asp   Leu Ser Glu Lys Thr   Pro Phe Phe Phe Arg   Val Leu Ala 
    28355                 28360                 28365             


Glu Asn   Glu Ile Gly Ile Gly   Glu Pro Cys Glu Thr   Thr Glu Pro 
    28370                 28375                 28380             


Val Lys   Ala Ala Glu Val Pro   Ala Pro Ile Arg Asp   Leu Ser Met 
    28385                 28390                 28395             


Lys Asp   Ser Thr Lys Thr Ser   Val Ile Leu Ser Trp   Thr Lys Pro 
    28400                 28405                 28410             


Asp Phe   Asp Gly Gly Ser Val   Ile Thr Glu Tyr Val   Val Glu Arg 
    28415                 28420                 28425             


Lys Gly   Lys Gly Glu Gln Thr   Trp Ser His Ala Gly   Ile Ser Lys 
    28430                 28435                 28440             


Thr Cys   Glu Ile Glu Val Ser   Gln Leu Lys Glu Gln   Ser Val Leu 
    28445                 28450                 28455             


Glu Phe   Arg Val Phe Ala Lys   Asn Glu Lys Gly Leu   Ser Asp Pro 
    28460                 28465                 28470             


Val Thr   Ile Gly Pro Ile Thr   Val Lys Glu Leu Ile   Ile Thr Pro 
    28475                 28480                 28485             


Glu Val   Asp Leu Ser Asp Ile   Pro Gly Ala Gln Val   Thr Val Arg 
    28490                 28495                 28500             


Ile Gly   His Asn Val His Leu   Glu Leu Pro Tyr Lys   Gly Lys Pro 
    28505                 28510                 28515             


Lys Pro   Ser Ile Ser Trp Leu   Lys Asp Gly Leu Pro   Leu Lys Glu 
    28520                 28525                 28530             


Ser Glu   Phe Val Arg Phe Ser   Lys Thr Glu Asn Lys   Ile Thr Leu 
    28535                 28540                 28545             


Ser Ile   Lys Asn Ala Lys Lys   Glu His Gly Gly Lys   Tyr Thr Val 
    28550                 28555                 28560             


Ile Leu   Asp Asn Ala Val Cys   Arg Ile Ala Val Pro   Ile Thr Val 
    28565                 28570                 28575             


Ile Thr   Leu Gly Pro Pro Ser   Lys Pro Lys Gly Pro   Ile Arg Phe 
    28580                 28585                 28590             


Asp Glu   Ile Lys Ala Asp Ser   Val Ile Leu Ser Trp   Asp Val Pro 
    28595                 28600                 28605             


Glu Asp   Asn Gly Gly Gly Glu   Ile Thr Cys Tyr Ser   Ile Glu Lys 
    28610                 28615                 28620             


Arg Glu   Thr Ser Gln Thr Asn   Trp Lys Met Val Cys   Ser Ser Val 
    28625                 28630                 28635             


Ala Arg   Thr Thr Phe Lys Val   Pro Asn Leu Val Lys   Asp Ala Glu 
    28640                 28645                 28650             


Tyr Gln   Phe Arg Val Arg Ala   Glu Asn Arg Tyr Gly   Val Ser Gln 
    28655                 28660                 28665             


Pro Leu   Val Ser Ser Ile Ile   Val Ala Lys His Gln   Phe Arg Ile 
    28670                 28675                 28680             


Pro Gly   Pro Pro Gly Lys Pro   Val Ile Tyr Asn Val   Thr Ser Asp 
    28685                 28690                 28695             


Gly Met   Ser Leu Thr Trp Asp   Ala Pro Val Tyr Asp   Gly Gly Ser 
    28700                 28705                 28710             


Glu Val   Thr Gly Phe His Val   Glu Lys Lys Glu Arg   Asn Ser Ile 
    28715                 28720                 28725             


Leu Trp   Gln Lys Val Asn Thr   Ser Pro Ile Ser Gly   Arg Glu Tyr 
    28730                 28735                 28740             


Arg Ala   Thr Gly Leu Val Glu   Gly Leu Asp Tyr Gln   Phe Arg Val 
    28745                 28750                 28755             


Tyr Ala   Glu Asn Ser Ala Gly   Leu Ser Ser Pro Ser   Asp Pro Ser 
    28760                 28765                 28770             


Lys Phe   Thr Leu Ala Val Ser   Pro Val Asp Pro Pro   Gly Thr Pro 
    28775                 28780                 28785             


Asp Tyr   Ile Asp Val Thr Arg   Glu Thr Ile Thr Leu   Lys Trp Asn 
    28790                 28795                 28800             


Pro Pro   Leu Arg Asp Gly Gly   Ser Lys Ile Val Gly   Tyr Ser Ile 
    28805                 28810                 28815             


Glu Lys   Arg Gln Gly Asn Glu   Arg Trp Val Arg Cys   Asn Phe Thr 
    28820                 28825                 28830             


Asp Val   Ser Glu Cys Gln Tyr   Thr Val Thr Gly Leu   Ser Pro Gly 
    28835                 28840                 28845             


Asp Arg   Tyr Glu Phe Arg Ile   Ile Ala Arg Asn Ala   Val Gly Thr 
    28850                 28855                 28860             


Ile Ser   Pro Pro Ser Gln Ser   Ser Gly Ile Ile Met   Thr Arg Asp 
    28865                 28870                 28875             


Glu Asn   Val Pro Pro Ile Val   Glu Phe Gly Pro Glu   Tyr Phe Asp 
    28880                 28885                 28890             


Gly Leu   Ile Ile Lys Ser Gly   Glu Ser Leu Arg Ile   Lys Ala Leu 
    28895                 28900                 28905             


Val Gln   Gly Arg Pro Val Pro   Arg Val Thr Trp Phe   Lys Asp Gly 
    28910                 28915                 28920             


Val Glu   Ile Glu Lys Arg Met   Asn Met Glu Ile Thr   Asp Val Leu 
    28925                 28930                 28935             


Gly Ser   Thr Ser Leu Phe Val   Arg Asp Ala Thr Arg   Asp His Arg 
    28940                 28945                 28950             


Gly Val   Tyr Thr Val Glu Ala   Lys Asn Ala Ser Gly   Ser Ala Lys 
    28955                 28960                 28965             


Ala Glu   Ile Lys Val Lys Val   Gln Asp Thr Pro Gly   Lys Val Val 
    28970                 28975                 28980             


Gly Pro   Ile Arg Phe Thr Asn   Ile Thr Gly Glu Lys   Met Thr Leu 
    28985                 28990                 28995             


Trp Trp   Asp Ala Pro Leu Asn   Asp Gly Cys Ala Pro   Ile Thr His 
    29000                 29005                 29010             


Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg Leu Ala   Trp Ala Leu 
    29015                 29020                 29025             


Ile Glu   Asp Lys Cys Glu Ala   Gln Ser Tyr Thr Ala   Ile Lys Leu 
    29030                 29035                 29040             


Ile Asn   Gly Asn Glu Tyr Gln   Phe Arg Val Ser Ala   Val Asn Lys 
    29045                 29050                 29055             


Phe Gly   Val Gly Arg Pro Leu   Asp Ser Asp Pro Val   Val Ala Gln 
    29060                 29065                 29070             


Ile Gln   Tyr Thr Val Pro Asp   Ala Pro Gly Ile Pro   Glu Pro Ser 
    29075                 29080                 29085             


Asn Ile   Thr Gly Asn Ser Ile   Thr Leu Thr Trp Ala   Arg Pro Glu 
    29090                 29095                 29100             


Ser Asp   Gly Gly Ser Glu Ile   Gln Gln Tyr Ile Leu   Glu Arg Arg 
    29105                 29110                 29115             


Glu Lys   Lys Ser Thr Arg Trp   Val Lys Val Ile Ser   Lys Arg Pro 
    29120                 29125                 29130             


Ile Ser   Glu Thr Arg Phe Lys   Val Thr Gly Leu Thr   Glu Gly Asn 
    29135                 29140                 29145             


Glu Tyr   Glu Phe His Val Met   Ala Glu Asn Ala Ala   Gly Val Gly 
    29150                 29155                 29160             


Pro Ala   Ser Gly Ile Ser Arg   Leu Ile Lys Cys Arg   Glu Pro Val 
    29165                 29170                 29175             


Asn Pro   Pro Gly Pro Pro Thr   Val Val Lys Val Thr   Asp Thr Ser 
    29180                 29185                 29190             


Lys Thr   Thr Val Ser Leu Glu   Trp Ser Lys Pro Val   Phe Asp Gly 
    29195                 29200                 29205             


Gly Met   Glu Ile Ile Gly Tyr   Ile Ile Glu Met Cys   Lys Ala Asp 
    29210                 29215                 29220             


Leu Gly   Asp Trp His Lys Val   Asn Ala Glu Ala Cys   Val Lys Thr 
    29225                 29230                 29235             


Arg Tyr   Thr Val Thr Asp Leu   Gln Ala Gly Glu Glu   Tyr Lys Phe 
    29240                 29245                 29250             


Arg Val   Ser Ala Ile Asn Gly   Ala Gly Lys Gly Asp   Ser Cys Glu 
    29255                 29260                 29265             


Val Thr   Gly Thr Ile Lys Ala   Val Asp Arg Leu Thr   Ala Pro Glu 
    29270                 29275                 29280             


Leu Asp   Ile Asp Ala Asn Phe   Lys Gln Thr His Val   Val Arg Ala 
    29285                 29290                 29295             


Gly Ala   Ser Ile Arg Leu Phe   Ile Ala Tyr Gln Gly   Arg Pro Thr 
    29300                 29305                 29310             


Pro Thr   Ala Val Trp Ser Lys   Pro Asp Ser Asn Leu   Ser Leu Arg 
    29315                 29320                 29325             


Ala Asp   Ile His Thr Thr Asp   Ser Phe Ser Thr Leu   Thr Val Glu 
    29330                 29335                 29340             


Asn Cys   Asn Arg Asn Asp Ala   Gly Lys Tyr Thr Leu   Thr Val Glu 
    29345                 29350                 29355             


Asn Asn   Ser Gly Ser Lys Ser   Ile Thr Phe Thr Val   Lys Val Leu 
    29360                 29365                 29370             


Asp Thr   Pro Gly Pro Pro Gly   Pro Ile Thr Phe Lys   Asp Val Thr 
    29375                 29380                 29385             


Arg Gly   Ser Ala Thr Leu Met   Trp Asp Ala Pro Leu   Leu Asp Gly 
    29390                 29395                 29400             


Gly Ala   Arg Ile His His Tyr   Val Val Glu Lys Arg   Glu Ala Ser 
    29405                 29410                 29415             


Arg Arg   Ser Trp Gln Val Ile   Ser Glu Lys Cys Thr   Arg Gln Ile 
    29420                 29425                 29430             


Phe Lys   Val Asn Asp Leu Ala   Glu Gly Val Pro Tyr   Tyr Phe Arg 
    29435                 29440                 29445             


Val Ser   Ala Val Asn Glu Tyr   Gly Val Gly Glu Pro   Tyr Glu Met 
    29450                 29455                 29460             


Pro Glu   Pro Ile Val Ala Thr   Glu Gln Pro Ala Pro   Pro Arg Arg 
    29465                 29470                 29475             


Leu Asp   Val Val Asp Thr Ser   Lys Ser Ser Ala Val   Leu Ala Trp 
    29480                 29485                 29490             


Leu Lys   Pro Asp His Asp Gly   Gly Ser Arg Ile Thr   Gly Tyr Leu 
    29495                 29500                 29505             


Leu Glu   Met Arg Gln Lys Gly   Ser Asp Phe Trp Val   Glu Ala Gly 
    29510                 29515                 29520             


His Thr   Lys Gln Leu Thr Phe   Thr Val Glu Arg Leu   Val Glu Lys 
    29525                 29530                 29535             


Thr Glu   Tyr Glu Phe Arg Val   Lys Ala Lys Asn Asp   Ala Gly Tyr 
    29540                 29545                 29550             


Ser Glu   Pro Arg Glu Ala Phe   Ser Ser Val Ile Ile   Lys Glu Pro 
    29555                 29560                 29565             


Gln Ile   Glu Pro Thr Ala Asp   Leu Thr Gly Ile Thr   Asn Gln Leu 
    29570                 29575                 29580             


Ile Thr   Cys Lys Ala Gly Ser   Pro Phe Thr Ile Asp   Val Pro Ile 
    29585                 29590                 29595             


Ser Gly   Arg Pro Ala Pro Lys   Val Thr Trp Lys Leu   Glu Glu Met 
    29600                 29605                 29610             


Arg Leu   Lys Glu Thr Asp Arg   Val Ser Ile Thr Thr   Thr Lys Asp 
    29615                 29620                 29625             


Arg Thr   Thr Leu Thr Val Lys   Asp Ser Met Arg Gly   Asp Ser Gly 
    29630                 29635                 29640             


Arg Tyr   Phe Leu Thr Leu Glu   Asn Thr Ala Gly Val   Lys Thr Phe 
    29645                 29650                 29655             


Ser Val   Thr Val Val Val Ile   Gly Arg Pro Gly Pro   Val Thr Gly 
    29660                 29665                 29670             


Pro Ile   Glu Val Ser Ser Val   Ser Ala Glu Ser Cys   Val Leu Ser 
    29675                 29680                 29685             


Trp Gly   Glu Pro Lys Asp Gly   Gly Gly Thr Glu Ile   Thr Asn Tyr 
    29690                 29695                 29700             


Ile Val   Glu Lys Arg Glu Ser   Gly Thr Thr Ala Trp   Gln Leu Val 
    29705                 29710                 29715             


Asn Ser   Ser Val Lys Arg Thr   Gln Ile Lys Val Thr   His Leu Thr 
    29720                 29725                 29730             


Lys Tyr   Met Glu Tyr Ser Phe   Arg Val Ser Ser Glu   Asn Arg Phe 
    29735                 29740                 29745             


Gly Val   Ser Lys Pro Leu Glu   Ser Ala Pro Ile Ile   Ala Glu His 
    29750                 29755                 29760             


Pro Phe   Val Pro Pro Ser Ala   Pro Thr Arg Pro Glu   Val Tyr His 
    29765                 29770                 29775             


Val Ser   Ala Asn Ala Met Ser   Ile Arg Trp Glu Glu   Pro Tyr His 
    29780                 29785                 29790             


Asp Gly   Gly Ser Lys Ile Ile   Gly Tyr Trp Val Glu   Lys Lys Glu 
    29795                 29800                 29805             


Arg Asn   Thr Ile Leu Trp Val   Lys Glu Asn Lys Val   Pro Cys Leu 
    29810                 29815                 29820             


Glu Cys   Asn Tyr Lys Val Thr   Gly Leu Val Glu Gly   Leu Glu Tyr 
    29825                 29830                 29835             


Gln Phe   Arg Thr Tyr Ala Leu   Asn Ala Ala Gly Val   Ser Lys Ala 
    29840                 29845                 29850             


Ser Glu   Ala Ser Arg Pro Ile   Met Ala Gln Asn Pro   Val Asp Ala 
    29855                 29860                 29865             


Pro Gly   Arg Pro Glu Val Thr   Asp Val Thr Arg Ser   Thr Val Ser 
    29870                 29875                 29880             


Leu Ile   Trp Ser Ala Pro Ala   Tyr Asp Gly Gly Ser   Lys Val Val 
    29885                 29890                 29895             


Gly Tyr   Ile Ile Glu Arg Lys   Pro Val Ser Glu Val   Gly Asp Gly 
    29900                 29905                 29910             


Arg Trp   Leu Lys Cys Asn Tyr   Thr Ile Val Ser Asp   Asn Phe Phe 
    29915                 29920                 29925             


Thr Val   Thr Ala Leu Ser Glu   Gly Asp Thr Tyr Glu   Phe Arg Val 
    29930                 29935                 29940             


Leu Ala   Lys Asn Ala Ala Gly   Val Ile Ser Lys Gly   Ser Glu Ser 
    29945                 29950                 29955             


Thr Gly   Pro Val Thr Cys Arg   Asp Glu Tyr Ala Pro   Pro Lys Ala 
    29960                 29965                 29970             


Glu Leu   Asp Ala Arg Leu His   Gly Asp Leu Val Thr   Ile Arg Ala 
    29975                 29980                 29985             


Gly Ser   Asp Leu Val Leu Asp   Ala Ala Val Gly Gly   Lys Pro Glu 
    29990                 29995                 30000             


Pro Lys   Ile Ile Trp Thr Lys   Gly Asp Lys Glu Leu   Asp Leu Cys 
    30005                 30010                 30015             


Glu Lys   Val Ser Leu Gln Tyr   Thr Gly Lys Arg Ala   Thr Ala Val 
    30020                 30025                 30030             


Ile Lys   Phe Cys Asp Arg Ser   Asp Ser Gly Lys Tyr   Thr Leu Thr 
    30035                 30040                 30045             


Val Lys   Asn Ala Ser Gly Thr   Lys Ala Val Ser Val   Met Val Lys 
    30050                 30055                 30060             


Val Leu   Asp Ser Pro Gly Pro   Cys Gly Lys Leu Thr   Val Ser Arg 
    30065                 30070                 30075             


Val Thr   Gln Glu Lys Cys Thr   Leu Ala Trp Ser Leu   Pro Gln Glu 
    30080                 30085                 30090             


Asp Gly   Gly Ala Glu Ile Thr   His Tyr Ile Val Glu   Arg Arg Glu 
    30095                 30100                 30105             


Thr Ser   Arg Leu Asn Trp Val   Ile Val Glu Gly Glu   Cys Pro Thr 
    30110                 30115                 30120             


Leu Ser   Tyr Val Val Thr Arg   Leu Ile Lys Asn Asn   Glu Tyr Ile 
    30125                 30130                 30135             


Phe Arg   Val Arg Ala Val Asn   Lys Tyr Gly Pro Gly   Val Pro Val 
    30140                 30145                 30150             


Glu Ser   Glu Pro Ile Val Ala   Arg Asn Ser Phe Thr   Ile Pro Ser 
    30155                 30160                 30165             


Pro Pro   Gly Ile Pro Glu Glu   Val Gly Thr Gly Lys   Glu His Ile 
    30170                 30175                 30180             


Ile Ile   Gln Trp Thr Lys Pro   Glu Ser Asp Gly Gly   Asn Glu Ile 
    30185                 30190                 30195             


Ser Asn   Tyr Leu Val Asp Lys   Arg Glu Lys Lys Ser   Leu Arg Trp 
    30200                 30205                 30210             


Thr Arg   Val Asn Lys Asp Tyr   Val Val Tyr Asp Thr   Arg Leu Lys 
    30215                 30220                 30225             


Val Thr   Ser Leu Met Glu Gly   Cys Asp Tyr Gln Phe   Arg Val Thr 
    30230                 30235                 30240             


Ala Val   Asn Ala Ala Gly Asn   Ser Glu Pro Ser Glu   Ala Ser Asn 
    30245                 30250                 30255             


Phe Ile   Ser Cys Arg Glu Pro   Ser Tyr Thr Pro Gly   Pro Pro Ser 
    30260                 30265                 30270             


Ala Pro   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Ser Leu Ala 
    30275                 30280                 30285             


Trp Thr   Lys Pro Met Tyr Asp   Gly Gly Thr Asp Ile   Val Gly Tyr 
    30290                 30295                 30300             


Val Leu   Glu Met Gln Glu Lys   Asp Thr Asp Gln Trp   Tyr Arg Val 
    30305                 30310                 30315             


His Thr   Asn Ala Thr Ile Arg   Asn Thr Glu Phe Thr   Val Pro Asp 
    30320                 30325                 30330             


Leu Lys   Met Gly Gln Lys Tyr   Ser Phe Arg Val Ala   Ala Val Asn 
    30335                 30340                 30345             


Val Lys   Gly Met Ser Glu Tyr   Ser Glu Ser Ile Ala   Glu Ile Glu 
    30350                 30355                 30360             


Pro Val   Glu Arg Ile Glu Ile   Pro Asp Leu Glu Leu   Ala Asp Asp 
    30365                 30370                 30375             


Leu Lys   Lys Thr Val Thr Ile   Arg Ala Gly Ala Ser   Leu Arg Leu 
    30380                 30385                 30390             


Met Val   Ser Val Ser Gly Arg   Pro Pro Pro Val Ile   Thr Trp Ser 
    30395                 30400                 30405             


Lys Gln   Gly Ile Asp Leu Ala   Ser Arg Ala Ile Ile   Asp Thr Thr 
    30410                 30415                 30420             


Glu Ser   Tyr Ser Leu Leu Ile   Val Asp Lys Val Asn   Arg Tyr Asp 
    30425                 30430                 30435             


Ala Gly   Lys Tyr Thr Ile Glu   Ala Glu Asn Gln Ser   Gly Lys Lys 
    30440                 30445                 30450             


Ser Ala   Thr Val Leu Val Lys   Val Tyr Asp Thr Pro   Gly Pro Cys 
    30455                 30460                 30465             


Pro Ser   Val Lys Val Lys Glu   Val Ser Arg Asp Ser   Val Thr Ile 
    30470                 30475                 30480             


Thr Trp   Glu Ile Pro Thr Ile   Asp Gly Gly Ala Pro   Val Asn Asn 
    30485                 30490                 30495             


Tyr Ile   Val Glu Lys Arg Glu   Ala Ala Met Arg Ala   Phe Lys Thr 
    30500                 30505                 30510             


Val Thr   Thr Lys Cys Ser Lys   Thr Leu Tyr Arg Ile   Ser Gly Leu 
    30515                 30520                 30525             


Val Glu   Gly Thr Met Tyr Tyr   Phe Arg Val Leu Pro   Glu Asn Ile 
    30530                 30535                 30540             


Tyr Gly   Ile Gly Glu Pro Cys   Glu Thr Ser Asp Ala   Val Leu Val 
    30545                 30550                 30555             


Ser Glu   Val Pro Leu Val Pro   Ala Lys Leu Glu Val   Val Asp Val 
    30560                 30565                 30570             


Thr Lys   Ser Thr Val Thr Leu   Ala Trp Glu Lys Pro   Leu Tyr Asp 
    30575                 30580                 30585             


Gly Gly   Ser Arg Leu Thr Gly   Tyr Val Leu Glu Ala   Cys Lys Ala 
    30590                 30595                 30600             


Gly Thr   Glu Arg Trp Met Lys   Val Val Thr Leu Lys   Pro Thr Val 
    30605                 30610                 30615             


Leu Glu   His Thr Val Thr Ser   Leu Asn Glu Gly Glu   Gln Tyr Leu 
    30620                 30625                 30630             


Phe Arg   Ile Arg Ala Gln Asn   Glu Lys Gly Val Ser   Glu Pro Arg 
    30635                 30640                 30645             


Glu Thr   Val Thr Ala Val Thr   Val Gln Asp Leu Arg   Val Leu Pro 
    30650                 30655                 30660             


Thr Ile   Asp Leu Ser Thr Met   Pro Gln Lys Thr Ile   His Val Pro 
    30665                 30670                 30675             


Ala Gly   Arg Pro Val Glu Leu   Val Ile Pro Ile Ala   Gly Arg Pro 
    30680                 30685                 30690             


Pro Pro   Ala Ala Ser Trp Phe   Phe Ala Gly Ser Lys   Leu Arg Glu 
    30695                 30700                 30705             


Ser Glu   Arg Val Thr Val Glu   Thr His Thr Lys Val   Ala Lys Leu 
    30710                 30715                 30720             


Thr Ile   Arg Glu Thr Thr Ile   Arg Asp Thr Gly Glu   Tyr Thr Leu 
    30725                 30730                 30735             


Glu Leu   Lys Asn Val Thr Gly   Thr Thr Ser Glu Thr   Ile Lys Val 
    30740                 30745                 30750             


Ile Ile   Leu Asp Lys Pro Gly   Pro Pro Thr Gly Pro   Ile Lys Ile 
    30755                 30760                 30765             


Asp Glu   Ile Asp Ala Thr Ser   Ile Thr Ile Ser Trp   Glu Pro Pro 
    30770                 30775                 30780             


Glu Leu   Asp Gly Gly Ala Pro   Leu Ser Gly Tyr Val   Val Glu Gln 
    30785                 30790                 30795             


Arg Asp   Ala His Arg Pro Gly   Trp Leu Pro Val Ser   Glu Ser Val 
    30800                 30805                 30810             


Thr Arg   Ser Thr Phe Lys Phe   Thr Arg Leu Thr Glu   Gly Asn Glu 
    30815                 30820                 30825             


Tyr Val   Phe Arg Val Ala Ala   Thr Asn Arg Phe Gly   Ile Gly Ser 
    30830                 30835                 30840             


Tyr Leu   Gln Ser Glu Val Ile   Glu Cys Arg Ser Ser   Ile Arg Ile 
    30845                 30850                 30855             


Pro Gly   Pro Pro Glu Thr Leu   Gln Ile Phe Asp Val   Ser Arg Asp 
    30860                 30865                 30870             


Gly Met   Thr Leu Thr Trp Tyr   Pro Pro Glu Asp Asp   Gly Gly Ser 
    30875                 30880                 30885             


Gln Val   Thr Gly Tyr Ile Val   Glu Arg Lys Glu Val   Arg Ala Asp 
    30890                 30895                 30900             


Arg Trp   Val Arg Val Asn Lys   Val Pro Val Thr Met   Thr Arg Tyr 
    30905                 30910                 30915             


Arg Ser   Thr Gly Leu Thr Glu   Gly Leu Glu Tyr Glu   His Arg Val 
    30920                 30925                 30930             


Thr Ala   Ile Asn Ala Arg Gly   Ser Gly Lys Pro Ser   Arg Pro Ser 
    30935                 30940                 30945             


Lys Pro   Ile Val Ala Met Asp   Pro Ile Ala Pro Pro   Gly Lys Pro 
    30950                 30955                 30960             


Gln Asn   Pro Arg Val Thr Asp   Thr Thr Arg Thr Ser   Val Ser Leu 
    30965                 30970                 30975             


Ala Trp   Ser Val Pro Glu Asp   Glu Gly Gly Ser Lys   Val Thr Gly 
    30980                 30985                 30990             


Tyr Leu   Ile Glu Met Gln Lys   Val Asp Gln His Glu   Trp Thr Lys 
    30995                 31000                 31005             


Cys Asn   Thr Thr Pro Thr Lys   Ile Arg Glu Tyr Thr   Leu Thr His 
    31010                 31015                 31020             


Leu Pro   Gln Gly Ala Glu Tyr   Arg Phe Arg Val Leu   Ala Cys Asn 
    31025                 31030                 31035             


Ala Gly   Gly Pro Gly Glu Pro   Ala Glu Val Pro Gly   Thr Val Lys 
    31040                 31045                 31050             


Val Thr   Glu Met Leu Glu Tyr   Pro Asp Tyr Glu Leu   Asp Glu Arg 
    31055                 31060                 31065             


Tyr Gln   Glu Gly Ile Phe Val   Arg Gln Gly Gly Val   Ile Arg Leu 
    31070                 31075                 31080             


Thr Ile   Pro Ile Lys Gly Lys   Pro Phe Pro Ile Cys   Lys Trp Thr 
    31085                 31090                 31095             


Lys Glu   Gly Gln Asp Ile Ser   Lys Arg Ala Met Ile   Ala Thr Ser 
    31100                 31105                 31110             


Glu Thr   His Thr Glu Leu Val   Ile Lys Glu Ala Asp   Arg Gly Asp 
    31115                 31120                 31125             


Ser Gly   Thr Tyr Asp Leu Val   Leu Glu Asn Lys Cys   Gly Lys Lys 
    31130                 31135                 31140             


Ala Val   Tyr Ile Lys Val Arg   Val Ile Gly Ser Pro   Asn Ser Pro 
    31145                 31150                 31155             


Glu Gly   Pro Leu Glu Tyr Asp   Asp Ile Gln Val Arg   Ser Val Arg 
    31160                 31165                 31170             


Val Ser   Trp Arg Pro Pro Ala   Asp Asp Gly Gly Ala   Asp Ile Leu 
    31175                 31180                 31185             


Gly Tyr   Ile Leu Glu Arg Arg   Glu Val Pro Lys Ala   Ala Trp Tyr 
    31190                 31195                 31200             


Thr Ile   Asp Ser Arg Val Arg   Gly Thr Ser Leu Val   Val Lys Gly 
    31205                 31210                 31215             


Leu Lys   Glu Asn Val Glu Tyr   His Phe Arg Val Ser   Ala Glu Asn 
    31220                 31225                 31230             


Gln Phe   Gly Ile Ser Lys Pro   Leu Lys Ser Glu Glu   Pro Val Thr 
    31235                 31240                 31245             


Pro Lys   Thr Pro Leu Asn Pro   Pro Glu Pro Pro Ser   Asn Pro Pro 
    31250                 31255                 31260             


Glu Val   Leu Asp Val Thr Lys   Ser Ser Val Ser Leu   Ser Trp Ser 
    31265                 31270                 31275             


Arg Pro   Lys Asp Asp Gly Gly   Ser Arg Val Thr Gly   Tyr Tyr Ile 
    31280                 31285                 31290             


Glu Arg   Lys Glu Thr Ser Thr   Asp Lys Trp Val Arg   His Asn Lys 
    31295                 31300                 31305             


Thr Gln   Ile Thr Thr Thr Met   Tyr Thr Val Thr Gly   Leu Val Pro 
    31310                 31315                 31320             


Asp Ala   Glu Tyr Gln Phe Arg   Ile Ile Ala Gln Asn   Asp Val Gly 
    31325                 31330                 31335             


Leu Ser   Glu Thr Ser Pro Ala   Ser Glu Pro Val Val   Cys Lys Asp 
    31340                 31345                 31350             


Pro Phe   Asp Lys Pro Ser Gln   Pro Gly Glu Leu Glu   Ile Leu Ser 
    31355                 31360                 31365             


Ile Ser   Lys Asp Ser Val Thr   Leu Gln Trp Glu Lys   Pro Glu Cys 
    31370                 31375                 31380             


Asp Gly   Gly Lys Glu Ile Leu   Gly Tyr Trp Val Glu   Tyr Arg Gln 
    31385                 31390                 31395             


Ser Gly   Asp Ser Ala Trp Lys   Lys Ser Asn Lys Glu   Arg Ile Lys 
    31400                 31405                 31410             


Asp Lys   Gln Phe Thr Ile Gly   Gly Leu Leu Glu Ala   Thr Glu Tyr 
    31415                 31420                 31425             


Glu Phe   Arg Val Phe Ala Glu   Asn Glu Thr Gly Leu   Ser Arg Pro 
    31430                 31435                 31440             


Arg Arg   Thr Ala Met Ser Ile   Lys Thr Lys Leu Thr   Ser Gly Glu 
    31445                 31450                 31455             


Ala Pro   Gly Ile Arg Lys Glu   Met Lys Asp Val Thr   Thr Lys Leu 
    31460                 31465                 31470             


Gly Glu   Ala Ala Gln Leu Ser   Cys Gln Ile Val Gly   Arg Pro Leu 
    31475                 31480                 31485             


Pro Asp   Ile Lys Trp Tyr Arg   Phe Gly Lys Glu Leu   Ile Gln Ser 
    31490                 31495                 31500             


Arg Lys   Tyr Lys Met Ser Ser   Asp Gly Arg Thr His   Thr Leu Thr 
    31505                 31510                 31515             


Val Met   Thr Glu Glu Gln Glu   Asp Glu Gly Val Tyr   Thr Cys Ile 
    31520                 31525                 31530             


Ala Thr   Asn Glu Val Gly Glu   Val Glu Thr Ser Ser   Lys Leu Leu 
    31535                 31540                 31545             


Leu Gln   Ala Thr Pro Gln Phe   His Pro Gly Tyr Pro   Leu Lys Glu 
    31550                 31555                 31560             


Lys Tyr   Tyr Gly Ala Val Gly   Ser Thr Leu Arg Leu   His Val Met 
    31565                 31570                 31575             


Tyr Ile   Gly Arg Pro Val Pro   Ala Met Thr Trp Phe   His Gly Gln 
    31580                 31585                 31590             


Lys Leu   Leu Gln Asn Ser Glu   Asn Ile Thr Ile Glu   Asn Thr Glu 
    31595                 31600                 31605             


His Tyr   Thr His Leu Val Met   Lys Asn Val Gln Arg   Lys Thr His 
    31610                 31615                 31620             


Ala Gly   Lys Tyr Lys Val Gln   Leu Ser Asn Val Phe   Gly Thr Val 
    31625                 31630                 31635             


Asp Ala   Ile Leu Asp Val Glu   Ile Gln Asp Lys Pro   Asp Lys Pro 
    31640                 31645                 31650             


Thr Gly   Pro Ile Val Ile Glu   Ala Leu Leu Lys Asn   Ser Ala Val 
    31655                 31660                 31665             


Ile Ser   Trp Lys Pro Pro Ala   Asp Asp Gly Gly Ser   Trp Ile Thr 
    31670                 31675                 31680             


Asn Tyr   Val Val Glu Lys Cys   Glu Ala Lys Glu Gly   Ala Glu Trp 
    31685                 31690                 31695             


Gln Leu   Val Ser Ser Ala Ile   Ser Val Thr Thr Cys   Arg Ile Val 
    31700                 31705                 31710             


Asn Leu   Thr Glu Asn Ala Gly   Tyr Tyr Phe Arg Val   Ser Ala Gln 
    31715                 31720                 31725             


Asn Thr   Phe Gly Ile Ser Asp   Pro Leu Glu Val Ser   Ser Val Val 
    31730                 31735                 31740             


Ile Ile   Lys Ser Pro Phe Glu   Lys Pro Gly Ala Pro   Gly Lys Pro 
    31745                 31750                 31755             


Thr Ile   Thr Ala Val Thr Lys   Asp Ser Cys Val Val   Ala Trp Lys 
    31760                 31765                 31770             


Pro Pro   Ala Ser Asp Gly Gly   Ala Lys Ile Arg Asn   Tyr Tyr Leu 
    31775                 31780                 31785             


Glu Lys   Arg Glu Lys Lys Gln   Asn Lys Trp Ile Ser   Val Thr Thr 
    31790                 31795                 31800             


Glu Glu   Ile Arg Glu Thr Val   Phe Ser Val Lys Asn   Leu Ile Glu 
    31805                 31810                 31815             


Gly Leu   Glu Tyr Glu Phe Arg   Val Lys Cys Glu Asn   Leu Gly Gly 
    31820                 31825                 31830             


Glu Ser   Glu Trp Ser Glu Ile   Ser Glu Pro Ile Thr   Pro Lys Ser 
    31835                 31840                 31845             


Asp Val   Pro Ile Gln Ala Pro   His Phe Lys Glu Glu   Leu Arg Asn 
    31850                 31855                 31860             


Leu Asn   Val Arg Tyr Gln Ser   Asn Ala Thr Leu Val   Cys Lys Val 
    31865                 31870                 31875             


Thr Gly   His Pro Lys Pro Ile   Val Lys Trp Tyr Arg   Gln Gly Lys 
    31880                 31885                 31890             


Glu Ile   Ile Ala Asp Gly Leu   Lys Tyr Arg Ile Gln   Glu Phe Lys 
    31895                 31900                 31905             


Gly Gly   Tyr His Gln Leu Ile   Ile Ala Ser Val Thr   Asp Asp Asp 
    31910                 31915                 31920             


Ala Thr   Val Tyr Gln Val Arg   Ala Thr Asn Gln Gly   Gly Ser Val 
    31925                 31930                 31935             


Ser Gly   Thr Ala Ser Leu Glu   Val Glu Val Pro Ala   Lys Ile His 
    31940                 31945                 31950             


Leu Pro   Lys Thr Leu Glu Gly   Met Gly Ala Val His   Ala Leu Arg 
    31955                 31960                 31965             


Gly Glu   Val Val Ser Ile Lys   Ile Pro Phe Ser Gly   Lys Pro Asp 
    31970                 31975                 31980             


Pro Val   Ile Thr Trp Gln Lys   Gly Gln Asp Leu Ile   Asp Asn Asn 
    31985                 31990                 31995             


Gly His   Tyr Gln Val Ile Val   Thr Arg Ser Phe Thr   Ser Leu Val 
    32000                 32005                 32010             


Phe Pro   Asn Gly Val Glu Arg   Lys Asp Ala Gly Phe   Tyr Val Val 
    32015                 32020                 32025             


Cys Ala   Lys Asn Arg Phe Gly   Ile Asp Gln Lys Thr   Val Glu Leu 
    32030                 32035                 32040             


Asp Val   Ala Asp Val Pro Asp   Pro Pro Arg Gly Val   Lys Val Ser 
    32045                 32050                 32055             


Asp Val   Ser Arg Asp Ser Val   Asn Leu Thr Trp Thr   Glu Pro Ala 
    32060                 32065                 32070             


Ser Asp   Gly Gly Ser Lys Ile   Thr Asn Tyr Ile Val   Glu Lys Cys 
    32075                 32080                 32085             


Ala Thr   Thr Ala Glu Arg Trp   Leu Arg Val Gly Gln   Ala Arg Glu 
    32090                 32095                 32100             


Thr Arg   Tyr Thr Val Ile Asn   Leu Phe Gly Lys Thr   Ser Tyr Gln 
    32105                 32110                 32115             


Phe Arg   Val Ile Ala Glu Asn   Lys Phe Gly Leu Ser   Lys Pro Ser 
    32120                 32125                 32130             


Glu Pro   Ser Glu Pro Thr Ile   Thr Lys Glu Asp Lys   Thr Arg Ala 
    32135                 32140                 32145             


Met Asn   Tyr Asp Glu Glu Val   Asp Glu Thr Arg Glu   Val Ser Met 
    32150                 32155                 32160             


Thr Lys   Ala Ser His Ser Ser   Thr Lys Glu Leu Tyr   Glu Lys Tyr 
    32165                 32170                 32175             


Met Ile   Ala Glu Asp Leu Gly   Arg Gly Glu Phe Gly   Ile Val His 
    32180                 32185                 32190             


Arg Cys   Val Glu Thr Ser Ser   Lys Lys Thr Tyr Met   Ala Lys Phe 
    32195                 32200                 32205             


Val Lys   Val Lys Gly Thr Asp   Gln Val Leu Val Lys   Lys Glu Ile 
    32210                 32215                 32220             


Ser Ile   Leu Asn Ile Ala Arg   His Arg Asn Ile Leu   His Leu His 
    32225                 32230                 32235             


Glu Ser   Phe Glu Ser Met Glu   Glu Leu Val Met Ile   Phe Glu Phe 
    32240                 32245                 32250             


Ile Ser   Gly Leu Asp Ile Phe   Glu Arg Ile Asn Thr   Ser Ala Phe 
    32255                 32260                 32265             


Glu Leu   Asn Glu Arg Glu Ile   Val Ser Tyr Val His   Gln Val Cys 
    32270                 32275                 32280             


Glu Ala   Leu Gln Phe Leu His   Ser His Asn Ile Gly   His Phe Asp 
    32285                 32290                 32295             


Ile Arg   Pro Glu Asn Ile Ile   Tyr Gln Thr Arg Arg   Ser Ser Thr 
    32300                 32305                 32310             


Ile Lys   Ile Ile Glu Phe Gly   Gln Ala Arg Gln Leu   Lys Pro Gly 
    32315                 32320                 32325             


Asp Asn   Phe Arg Leu Leu Phe   Thr Ala Pro Glu Tyr   Tyr Ala Pro 
    32330                 32335                 32340             


Glu Val   His Gln His Asp Val   Val Ser Thr Ala Thr   Asp Met Trp 
    32345                 32350                 32355             


Ser Leu   Gly Thr Leu Val Tyr   Val Leu Leu Ser Gly   Ile Asn Pro 
    32360                 32365                 32370             


Phe Leu   Ala Glu Thr Asn Gln   Gln Ile Ile Glu Asn   Ile Met Asn 
    32375                 32380                 32385             


Ala Glu   Tyr Thr Phe Asp Glu   Glu Ala Phe Lys Glu   Ile Ser Ile 
    32390                 32395                 32400             


Glu Ala   Met Asp Phe Val Asp   Arg Leu Leu Val Lys   Glu Arg Lys 
    32405                 32410                 32415             


Ser Arg   Met Thr Ala Ser Glu   Ala Leu Gln His Pro   Trp Leu Lys 
    32420                 32425                 32430             


Gln Lys   Ile Glu Arg Val Ser   Thr Lys Val Ile Arg   Thr Leu Lys 
    32435                 32440                 32445             


His Arg   Arg Tyr Tyr His Thr   Leu Ile Lys Lys Asp   Leu Asn Met 
    32450                 32455                 32460             


Val Val   Ser Ala Ala Arg Ile   Ser Cys Gly Gly Ala   Ile Arg Ser 
    32465                 32470                 32475             


Gln Lys   Gly Val Ser Val Ala   Lys Val Lys Val Ala   Ser Ile Glu 
    32480                 32485                 32490             


Ile Gly   Pro Val Ser Gly Gln   Ile Met His Ala Val   Gly Glu Glu 
    32495                 32500                 32505             


Gly Gly   His Val Lys Tyr Val   Cys Lys Ile Glu Asn   Tyr Asp Gln 
    32510                 32515                 32520             


Ser Thr   Gln Val Thr Trp Tyr   Phe Gly Val Arg Gln   Leu Glu Asn 
    32525                 32530                 32535             


Ser Glu   Lys Tyr Glu Ile Thr   Tyr Glu Asp Gly Val   Ala Ile Leu 
    32540                 32545                 32550             


Tyr Val   Lys Asp Ile Thr Lys   Leu Asp Asp Gly Thr   Tyr Arg Cys 
    32555                 32560                 32565             


Lys Val   Val Asn Asp Tyr Gly   Glu Asp Ser Ser Tyr   Ala Glu Leu 
    32570                 32575                 32580             


Phe Val   Lys Gly Val Arg Glu   Val Tyr Asp Tyr Tyr   Cys Arg Arg 
    32585                 32590                 32595             


Thr Met   Lys Lys Ile Lys Arg   Arg Thr Asp Thr Met   Arg Leu Leu 
    32600                 32605                 32610             


Glu Arg   Pro Pro Glu Phe Thr   Leu Pro Leu Tyr Asn   Lys Thr Ala 
    32615                 32620                 32625             


Tyr Val   Gly Glu Asn Val Arg   Phe Gly Val Thr Ile   Thr Val His 
    32630                 32635                 32640             


Pro Glu   Pro His Val Thr Trp   Tyr Lys Ser Gly Gln   Lys Ile Lys 
    32645                 32650                 32655             


Pro Gly   Asp Asn Asp Lys Lys   Tyr Thr Phe Glu Ser   Asp Lys Gly 
    32660                 32665                 32670             


Leu Tyr   Gln Leu Thr Ile Asn   Ser Val Thr Thr Asp   Asp Asp Ala 
    32675                 32680                 32685             


Glu Tyr   Thr Val Val Ala Arg   Asn Lys Tyr Gly Glu   Asp Ser Cys 
    32690                 32695                 32700             


Lys Ala   Lys Leu Thr Val Thr   Leu His Pro Pro Pro   Thr Asp Ser 
    32705                 32710                 32715             


Thr Leu   Arg Pro Met Phe Lys   Arg Leu Leu Ala Asn   Ala Glu Cys 
    32720                 32725                 32730             


Gln Glu   Gly Gln Ser Val Cys   Phe Glu Ile Arg Val   Ser Gly Ile 
    32735                 32740                 32745             


Pro Pro   Pro Thr Leu Lys Trp   Glu Lys Asp Gly Gln   Pro Leu Ser 
    32750                 32755                 32760             


Leu Gly   Pro Asn Ile Glu Ile   Ile His Glu Gly Leu   Asp Tyr Tyr 
    32765                 32770                 32775             


Ala Leu   His Ile Arg Asp Thr   Leu Pro Glu Asp Thr   Gly Tyr Tyr 
    32780                 32785                 32790             


Arg Val   Thr Ala Thr Asn Thr   Ala Gly Ser Thr Ser   Cys Gln Ala 
    32795                 32800                 32805             


His Leu   Gln Val Glu Arg Leu   Arg Tyr Lys Lys Gln   Glu Phe Lys 
    32810                 32815                 32820             


Ser Lys   Glu Glu His Glu Arg   His Val Gln Lys Gln   Ile Asp Lys 
    32825                 32830                 32835             


Thr Leu   Arg Met Ala Glu Ile   Leu Ser Gly Thr Glu   Ser Val Pro 
    32840                 32845                 32850             


Leu Thr   Gln Val Ala Lys Glu   Ala Leu Arg Glu Ala   Ala Val Leu 
    32855                 32860                 32865             


Tyr Lys   Pro Ala Val Ser Thr   Lys Thr Val Lys Gly   Glu Phe Arg 
    32870                 32875                 32880             


Leu Glu   Ile Glu Glu Lys Lys   Glu Glu Arg Lys Leu   Arg Met Pro 
    32885                 32890                 32895             


Tyr Asp   Val Pro Glu Pro Arg   Lys Tyr Lys Gln Thr   Thr Ile Glu 
    32900                 32905                 32910             


Glu Asp   Gln Arg Ile Lys Gln   Phe Val Pro Met Ser   Asp Met Lys 
    32915                 32920                 32925             


Trp Tyr   Lys Lys Ile Arg Asp   Gln Tyr Glu Met Pro   Gly Lys Leu 
    32930                 32935                 32940             


Asp Arg   Val Val Gln Lys Arg   Pro Lys Arg Ile Arg   Leu Ser Arg 
    32945                 32950                 32955             


Trp Glu   Gln Phe Tyr Val Met   Pro Leu Pro Arg Ile   Thr Asp Gln 
    32960                 32965                 32970             


Tyr Arg   Pro Lys Trp Arg Ile   Pro Lys Leu Ser Gln   Asp Asp Leu 
    32975                 32980                 32985             


Glu Ile   Val Arg Pro Ala Arg   Arg Arg Thr Pro Ser   Pro Asp Tyr 
    32990                 32995                 33000             


Asp Phe   Tyr Tyr Arg Pro Arg   Arg Arg Ser Leu Gly   Asp Ile Ser 
    33005                 33010                 33015             


Asp Glu   Glu Leu Leu Leu Pro   Ile Asp Asp Tyr Leu   Ala Met Lys 
    33020                 33025                 33030             


Arg Thr   Glu Glu Glu Arg Leu   Arg Leu Glu Glu Glu   Leu Glu Leu 
    33035                 33040                 33045             


Gly Phe   Ser Ala Ser Pro Pro   Ser Arg Ser Pro Pro   His Phe Glu 
    33050                 33055                 33060             


Leu Ser   Ser Leu Arg Tyr Ser   Ser Pro Gln Ala His   Val Lys Val 
    33065                 33070                 33075             


Glu Glu   Thr Arg Lys Asp Phe   Arg Tyr Ser Thr Tyr   His Ile Pro 
    33080                 33085                 33090             


Thr Lys   Ala Glu Ala Ser Thr   Ser Tyr Ala Glu Leu   Arg Glu Arg 
    33095                 33100                 33105             


His Ala   Gln Ala Ala Tyr Arg   Gln Pro Lys Gln Arg   Gln Arg Ile 
    33110                 33115                 33120             


Met Ala   Glu Arg Glu Asp Glu   Glu Leu Leu Arg Pro   Val Thr Thr 
    33125                 33130                 33135             


Thr Gln   His Leu Ser Glu Tyr   Lys Ser Glu Leu Asp   Phe Met Ser 
    33140                 33145                 33150             


Lys Glu   Glu Lys Ser Arg Lys   Lys Ser Arg Arg Gln   Arg Glu Val 
    33155                 33160                 33165             


Thr Glu   Ile Thr Glu Ile Glu   Glu Glu Tyr Glu Ile   Ser Lys His 
    33170                 33175                 33180             


Ala Gln   Arg Glu Ser Ser Ser   Ser Ala Ser Arg Leu   Leu Arg Arg 
    33185                 33190                 33195             


Arg Arg   Ser Leu Ser Pro Thr   Tyr Ile Glu Leu Met   Arg Pro Val 
    33200                 33205                 33210             


Ser Glu   Leu Ile Arg Ser Arg   Pro Gln Pro Ala Glu   Glu Tyr Glu 
    33215                 33220                 33225             


Asp Asp   Thr Glu Arg Arg Ser   Pro Thr Pro Glu Arg   Thr Arg Pro 
    33230                 33235                 33240             


Arg Ser   Pro Ser Pro Val Ser   Ser Glu Arg Ser Leu   Ser Arg Phe 
    33245                 33250                 33255             


Glu Arg   Ser Ala Arg Phe Asp   Ile Phe Ser Arg Tyr   Glu Ser Met 
    33260                 33265                 33270             


Lys Ala   Ala Leu Lys Thr Gln   Lys Thr Ser Glu Arg   Lys Tyr Glu 
    33275                 33280                 33285             


Val Leu   Ser Gln Gln Pro Phe   Thr Leu Asp His Ala   Pro Arg Ile 
    33290                 33295                 33300             


Thr Leu   Arg Met Arg Ser His   Arg Val Pro Cys Gly   Gln Asn Thr 
    33305                 33310                 33315             


Arg Phe   Ile Leu Asn Val Gln   Ser Lys Pro Thr Ala   Glu Val Lys 
    33320                 33325                 33330             


Trp Tyr   His Asn Gly Val Glu   Leu Gln Glu Ser Ser   Lys Ile His 
    33335                 33340                 33345             


Tyr Thr   Asn Thr Ser Gly Val   Leu Thr Leu Glu Ile   Leu Asp Cys 
    33350                 33355                 33360             


His Thr   Asp Asp Ser Gly Thr   Tyr Arg Ala Val Cys   Thr Asn Tyr 
    33365                 33370                 33375             


Lys Gly   Glu Ala Ser Asp Tyr   Ala Thr Leu Asp Val   Thr Gly Gly 
    33380                 33385                 33390             


Asp Tyr   Thr Thr Tyr Ala Ser   Gln Arg Arg Asp Glu   Glu Val Pro 
    33395                 33400                 33405             


Arg Ser   Val Phe Pro Glu Leu   Thr Arg Thr Glu Ala   Tyr Ala Val 
    33410                 33415                 33420             


Ser Ser   Phe Lys Lys Thr Ser   Glu Met Glu Ala Ser   Ser Ser Val 
    33425                 33430                 33435             


Arg Glu   Val Lys Ser Gln Met   Thr Glu Thr Arg Glu   Ser Leu Ser 
    33440                 33445                 33450             


Ser Tyr   Glu His Ser Ala Ser   Ala Glu Met Lys Ser   Ala Ala Leu 
    33455                 33460                 33465             


Glu Glu   Lys Ser Leu Glu Glu   Lys Ser Thr Thr Arg   Lys Ile Lys 
    33470                 33475                 33480             


Thr Thr   Leu Ala Ala Arg Ile   Leu Thr Lys Pro Arg   Ser Met Thr 
    33485                 33490                 33495             


Val Tyr   Glu Gly Glu Ser Ala   Arg Phe Ser Cys Asp   Thr Asp Gly 
    33500                 33505                 33510             


Glu Pro   Val Pro Thr Val Thr   Trp Leu Arg Lys Gly   Gln Val Leu 
    33515                 33520                 33525             


Ser Thr   Ser Ala Arg His Gln   Val Thr Thr Thr Lys   Tyr Lys Ser 
    33530                 33535                 33540             


Thr Phe   Glu Ile Ser Ser Val   Gln Ala Ser Asp Glu   Gly Asn Tyr 
    33545                 33550                 33555             


Ser Val   Val Val Glu Asn Ser   Glu Gly Lys Gln Glu   Ala Glu Phe 
    33560                 33565                 33570             


Thr Leu   Thr Ile Gln Lys Ala   Arg Val Thr Glu Lys   Ala Val Thr 
    33575                 33580                 33585             


Ser Pro   Pro Arg Val Lys Ser   Pro Glu Pro Arg Val   Lys Ser Pro 
    33590                 33595                 33600             


Glu Ala   Val Lys Ser Pro Lys   Arg Val Lys Ser Pro   Glu Pro Ser 
    33605                 33610                 33615             


His Pro   Lys Ala Val Ser Pro   Thr Glu Thr Lys Pro   Thr Pro Thr 
    33620                 33625                 33630             


Glu Lys   Val Gln His Leu Pro   Val Ser Ala Pro Pro   Lys Ile Thr 
    33635                 33640                 33645             


Gln Phe   Leu Lys Ala Glu Ala   Ser Lys Glu Ile Ala   Lys Leu Thr 
    33650                 33655                 33660             


Cys Val   Val Glu Ser Ser Val   Leu Arg Ala Lys Glu   Val Thr Trp 
    33665                 33670                 33675             


Tyr Lys   Asp Gly Lys Lys Leu   Lys Glu Asn Gly His   Phe Gln Phe 
    33680                 33685                 33690             


His Tyr   Ser Ala Asp Gly Thr   Tyr Glu Leu Lys Ile   Asn Asn Leu 
    33695                 33700                 33705             


Thr Glu   Ser Asp Gln Gly Glu   Tyr Val Cys Glu Ile   Ser Gly Glu 
    33710                 33715                 33720             


Gly Gly   Thr Ser Lys Thr Asn   Leu Gln Phe Met Gly   Gln Ala Phe 
    33725                 33730                 33735             


Lys Ser   Ile His Glu Lys Val   Ser Lys Ile Ser Glu   Thr Lys Lys 
    33740                 33745                 33750             


Ser Asp   Gln Lys Thr Thr Glu   Ser Thr Val Thr Arg   Lys Thr Glu 
    33755                 33760                 33765             


Pro Lys   Ala Pro Glu Pro Ile   Ser Ser Lys Pro Val   Ile Val Thr 
    33770                 33775                 33780             


Gly Leu   Gln Asp Thr Thr Val   Ser Ser Asp Ser Val   Ala Lys Phe 
    33785                 33790                 33795             


Ala Val   Lys Ala Thr Gly Glu   Pro Arg Pro Thr Ala   Ile Trp Thr 
    33800                 33805                 33810             


Lys Asp   Gly Lys Ala Ile Thr   Gln Gly Gly Lys Tyr   Lys Leu Ser 
    33815                 33820                 33825             


Glu Asp   Lys Gly Gly Phe Phe   Leu Glu Ile His Lys   Thr Asp Thr 
    33830                 33835                 33840             


Ser Asp   Ser Gly Leu Tyr Thr   Cys Thr Val Lys Asn   Ser Ala Gly 
    33845                 33850                 33855             


Ser Val   Ser Ser Ser Cys Lys   Leu Thr Ile Lys Ala   Ile Lys Asp 
    33860                 33865                 33870             


Thr Glu   Ala Gln Lys Val Ser   Thr Gln Lys Thr Ser   Glu Ile Thr 
    33875                 33880                 33885             


Pro Gln   Lys Lys Ala Val Val   Gln Glu Glu Ile Ser   Gln Lys Ala 
    33890                 33895                 33900             


Leu Arg   Ser Glu Glu Ile Lys   Met Ser Glu Ala Lys   Ser Gln Glu 
    33905                 33910                 33915             


Lys Leu   Ala Leu Lys Glu Glu   Ala Ser Lys Val Leu   Ile Ser Glu 
    33920                 33925                 33930             


Glu Val   Lys Lys Ser Ala Ala   Thr Ser Leu Glu Lys   Ser Ile Val 
    33935                 33940                 33945             


His Glu   Glu Ile Thr Lys Thr   Ser Gln Ala Ser Glu   Glu Val Arg 
    33950                 33955                 33960             


Thr His   Ala Glu Ile Lys Ala   Phe Ser Thr Gln Met   Ser Ile Asn 
    33965                 33970                 33975             


Glu Gly   Gln Arg Leu Val Leu   Lys Ala Asn Ile Ala   Gly Ala Thr 
    33980                 33985                 33990             


Asp Val   Lys Trp Val Leu Asn   Gly Val Glu Leu Thr   Asn Ser Glu 
    33995                 34000                 34005             


Glu Tyr   Arg Tyr Gly Val Ser   Gly Ser Asp Gln Thr   Leu Thr Ile 
    34010                 34015                 34020             


Lys Gln   Ala Ser His Arg Asp   Glu Gly Ile Leu Thr   Cys Ile Ser 
    34025                 34030                 34035             


Lys Thr   Lys Glu Gly Ile Val   Lys Cys Gln Tyr Asp   Leu Thr Leu 
    34040                 34045                 34050             


Ser Lys   Glu Leu Ser Asp Ala   Pro Ala Phe Ile Ser   Gln Pro Arg 
    34055                 34060                 34065             


Ser Gln   Asn Ile Asn Glu Gly   Gln Asn Val Leu Phe   Thr Cys Glu 
    34070                 34075                 34080             


Ile Ser   Gly Glu Pro Ser Pro   Glu Ile Glu Trp Phe   Lys Asn Asn 
    34085                 34090                 34095             


Leu Pro   Ile Ser Ile Ser Ser   Asn Val Ser Ile Ser   Arg Ser Arg 
    34100                 34105                 34110             


Asn Val   Tyr Ser Leu Glu Ile   Arg Asn Ala Ser Val   Ser Asp Ser 
    34115                 34120                 34125             


Gly Lys   Tyr Thr Ile Lys Ala   Lys Asn Phe Arg Gly   Gln Cys Ser 
    34130                 34135                 34140             


Ala Thr   Ala Ser Leu Met Val   Leu Pro Leu Val Glu   Glu Pro Ser 
    34145                 34150                 34155             


Arg Glu   Val Val Leu Arg Thr   Ser Gly Asp Thr Ser   Leu Gln Gly 
    34160                 34165                 34170             


Ser Phe   Ser Ser Gln Ser Val   Gln Met Ser Ala Ser   Lys Gln Glu 
    34175                 34180                 34185             


Ala Ser   Phe Ser Ser Phe Ser   Ser Ser Ser Ala Ser   Ser Met Thr 
    34190                 34195                 34200             


Glu Met   Lys Phe Ala Ser Met   Ser Ala Gln Ser Met   Ser Ser Met 
    34205                 34210                 34215             


Gln Glu   Ser Phe Val Glu Met   Ser Ser Ser Ser Phe   Met Gly Ile 
    34220                 34225                 34230             


Ser Asn   Met Thr Gln Leu Glu   Ser Ser Thr Ser Lys   Met Leu Lys 
    34235                 34240                 34245             


Ala Gly   Ile Arg Gly Ile Pro   Pro Lys Ile Glu Ala   Leu Pro Ser 
    34250                 34255                 34260             


Asp Ile   Ser Ile Asp Glu Gly   Lys Val Leu Thr Val   Ala Cys Ala 
    34265                 34270                 34275             


Phe Thr   Gly Glu Pro Thr Pro   Glu Val Thr Trp Ser   Cys Gly Gly 
    34280                 34285                 34290             


Arg Lys   Ile His Ser Gln Glu   Gln Gly Arg Phe His   Ile Glu Asn 
    34295                 34300                 34305             


Thr Asp   Asp Leu Thr Thr Leu   Ile Ile Met Asp Val   Gln Lys Gln 
    34310                 34315                 34320             


Asp Gly   Gly Leu Tyr Thr Leu   Ser Leu Gly Asn Glu   Phe Gly Ser 
    34325                 34330                 34335             


Asp Ser   Ala Thr Val Asn Ile   His Ile Arg Ser Ile   
    34340                 34345                 34350 


<210>  7665
<211>  26926
<212>  PRT
<213>  Homo sapiens

<400>  7665

Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro His Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Met Lys Glu Thr Arg 
545                 550                 555                 560 


Lys Thr Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu 
                565                 570                 575     


Gln Asp Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu 
            580                 585                 590         


Gln Val Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr 
        595                 600                 605             


Ala Leu Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu 
    610                 615                 620                 


Thr Ile Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile 
625                 630                 635                 640 


Gln Val Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val 
                645                 650                 655     


Ala Thr Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg 
            660                 665                 670         


Glu Pro Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu 
        675                 680                 685             


Tyr Gly Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro 
    690                 695                 700                 


Gln Arg Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro 
705                 710                 715                 720 


Arg Val Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln 
                725                 730                 735     


Lys Gly Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr 
            740                 745                 750         


Thr Glu Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro 
        755                 760                 765             


His Phe Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr 
    770                 775                 780                 


Glu Ala Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu 
785                 790                 795                 800 


Ser Ala Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro 
                805                 810                 815     


Thr Val Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu 
            820                 825                 830         


Pro Gln Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala 
        835                 840                 845             


Gly Val Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr 
    850                 855                 860                 


Val Arg Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val 
865                 870                 875                 880 


Thr Glu Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro 
                885                 890                 895     


Pro Thr Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu 
            900                 905                 910         


Ser Val Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val 
        915                 920                 925             


Thr Trp Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln 
    930                 935                 940                 


Ile Thr Phe Gln Ser Gly Ile Ala Arg Leu Met Ile Arg Glu Ala Phe 
945                 950                 955                 960 


Ala Glu Asp Ser Gly Arg Phe Thr Cys Ser Ala Val Asn Glu Ala Gly 
                965                 970                 975     


Thr Val Ser Thr Ser Cys Tyr Leu Ala Val Gln Val Ser Glu Glu Phe 
            980                 985                 990         


Glu Lys Glu Thr Thr Ala Val Thr  Glu Lys Phe Thr Thr  Glu Glu Lys 
        995                 1000                 1005             


Arg Phe  Val Glu Ser Arg Asp  Val Val Met Thr Asp  Thr Ser Leu 
    1010                 1015                 1020             


Thr Glu  Glu Gln Ala Gly Pro  Gly Glu Pro Ala Ala  Pro Tyr Phe 
    1025                 1030                 1035             


Ile Thr  Lys Pro Val Val Gln  Lys Leu Val Glu Gly  Gly Ser Val 
    1040                 1045                 1050             


Val Phe  Gly Cys Gln Val Gly  Gly Asn Pro Lys Pro  His Val Tyr 
    1055                 1060                 1065             


Trp Lys  Lys Ser Gly Val Pro  Leu Thr Thr Gly Tyr  Arg Tyr Lys 
    1070                 1075                 1080             


Val Ser  Tyr Asn Lys Gln Thr  Gly Glu Cys Lys Leu  Val Ile Ser 
    1085                 1090                 1095             


Met Thr  Phe Ala Asp Asp Ala  Gly Glu Tyr Thr Ile  Val Val Arg 
    1100                 1105                 1110             


Asn Lys  His Gly Glu Thr Ser  Ala Ser Ala Ser Leu  Leu Glu Glu 
    1115                 1120                 1125             


Ala Asp  Tyr Glu Leu Leu Met  Lys Ser Gln Gln Glu  Met Leu Tyr 
    1130                 1135                 1140             


Gln Thr  Gln Val Thr Ala Phe  Val Gln Glu Pro Lys  Val Gly Glu 
    1145                 1150                 1155             


Thr Ala  Pro Gly Phe Val Tyr  Ser Glu Tyr Glu Lys  Glu Tyr Glu 
    1160                 1165                 1170             


Lys Glu  Gln Ala Leu Ile Arg  Lys Lys Met Ala Lys  Asp Thr Val 
    1175                 1180                 1185             


Val Val  Arg Thr Tyr Val Glu  Asp Gln Glu Phe His  Ile Ser Ser 
    1190                 1195                 1200             


Phe Glu  Glu Arg Leu Ile Lys  Glu Ile Glu Tyr Arg  Ile Ile Lys 
    1205                 1210                 1215             


Thr Thr  Leu Glu Glu Leu Leu  Glu Glu Asp Gly Glu  Glu Lys Met 
    1220                 1225                 1230             


Ala Val  Asp Ile Ser Glu Ser  Glu Ala Val Glu Ser  Gly Phe Asp 
    1235                 1240                 1245             


Leu Arg  Ile Lys Asn Tyr Arg  Ile Leu Glu Gly Met  Gly Val Thr 
    1250                 1255                 1260             


Phe His  Cys Lys Met Ser Gly  Tyr Pro Leu Pro Lys  Ile Ala Trp 
    1265                 1270                 1275             


Tyr Lys  Asp Gly Lys Arg Ile  Lys His Gly Glu Arg  Tyr Gln Met 
    1280                 1285                 1290             


Asp Phe  Leu Gln Asp Gly Arg  Ala Ser Leu Arg Ile  Pro Val Val 
    1295                 1300                 1305             


Leu Pro  Glu Asp Glu Gly Ile  Tyr Thr Ala Phe Ala  Ser Asn Ile 
    1310                 1315                 1320             


Lys Gly  Asn Ala Ile Cys Ser  Gly Lys Leu Tyr Val  Glu Pro Ala 
    1325                 1330                 1335             


Ala Pro  Leu Gly Ala Pro Thr  Tyr Ile Pro Thr Leu  Glu Pro Val 
    1340                 1345                 1350             


Ser Arg  Ile Arg Ser Leu Ser  Pro Arg Ser Val Ser  Arg Ser Pro 
    1355                 1360                 1365             


Ile Arg  Met Ser Pro Ala Arg  Met Ser Pro Ala Arg  Met Ser Pro 
    1370                 1375                 1380             


Ala Arg  Met Ser Pro Ala Arg  Met Ser Pro Gly Arg  Arg Leu Glu 
    1385                 1390                 1395             


Glu Thr  Asp Glu Ser Gln Leu  Glu Arg Leu Tyr Lys  Pro Val Phe 
    1400                 1405                 1410             


Val Leu  Lys Pro Val Ser Phe  Lys Cys Leu Glu Gly  Gln Thr Ala 
    1415                 1420                 1425             


Arg Phe  Asp Leu Lys Val Val  Gly Arg Pro Met Pro  Glu Thr Phe 
    1430                 1435                 1440             


Trp Phe  His Asp Gly Gln Gln  Ile Val Asn Asp Tyr  Thr His Lys 
    1445                 1450                 1455             


Val Val  Ile Lys Glu Asp Gly  Thr Gln Ser Leu Ile  Ile Val Pro 
    1460                 1465                 1470             


Ala Thr  Pro Ser Asp Ser Gly  Glu Trp Thr Val Val  Ala Gln Asn 
    1475                 1480                 1485             


Arg Ala  Gly Arg Ser Ser Ile  Ser Val Ile Leu Thr  Val Glu Ala 
    1490                 1495                 1500             


Val Glu  His Gln Val Lys Pro  Met Phe Val Glu Lys  Leu Lys Asn 
    1505                 1510                 1515             


Val Asn  Ile Lys Glu Gly Ser  Gln Leu Glu Met Lys  Val Arg Ala 
    1520                 1525                 1530             


Thr Gly  Asn Pro Asn Pro Asp  Ile Val Trp Leu Lys  Asn Ser Asp 
    1535                 1540                 1545             


Ile Ile  Val Pro His Lys Tyr  Pro Lys Ile Arg Ile  Glu Gly Thr 
    1550                 1555                 1560             


Lys Gly  Glu Ala Ala Leu Lys  Ile Asp Ser Thr Val  Ser Gln Asp 
    1565                 1570                 1575             


Ser Ala  Trp Tyr Thr Ala Thr  Ala Ile Asn Lys Ala  Gly Arg Asp 
    1580                 1585                 1590             


Thr Thr  Arg Cys Lys Val Asn  Val Glu Val Glu Phe  Ala Glu Pro 
    1595                 1600                 1605             


Glu Pro  Glu Arg Lys Leu Ile  Ile Pro Arg Gly Thr  Tyr Arg Ala 
    1610                 1615                 1620             


Lys Glu  Ile Ala Ala Pro Glu  Leu Glu Pro Leu His  Leu Arg Tyr 
    1625                 1630                 1635             


Gly Gln  Glu Gln Trp Glu Glu  Gly Asp Leu Tyr Asp  Lys Glu Lys 
    1640                 1645                 1650             


Gln Gln  Lys Pro Phe Phe Lys  Lys Lys Leu Thr Ser  Leu Arg Leu 
    1655                 1660                 1665             


Lys Arg  Phe Gly Pro Ala His  Phe Glu Cys Arg Leu  Thr Pro Ile 
    1670                 1675                 1680             


Gly Asp  Pro Thr Met Val Val  Glu Trp Leu His Asp  Gly Lys Pro 
    1685                 1690                 1695             


Leu Glu  Ala Ala Asn Arg Leu  Arg Met Ile Asn Glu  Phe Gly Tyr 
    1700                 1705                 1710             


Cys Ser  Leu Asp Tyr Gly Val  Ala Tyr Ser Arg Asp  Ser Gly Ile 
    1715                 1720                 1725             


Ile Thr  Cys Arg Ala Thr Asn  Lys Tyr Gly Thr Asp  His Thr Ser 
    1730                 1735                 1740             


Ala Thr  Leu Ile Val Lys Asp  Glu Lys Ser Leu Val  Glu Glu Ser 
    1745                 1750                 1755             


Gln Leu  Pro Glu Gly Arg Lys  Gly Leu Gln Arg Ile  Glu Glu Leu 
    1760                 1765                 1770             


Glu Arg  Met Ala His Glu Gly  Ala Leu Thr Gly Val  Thr Thr Asp 
    1775                 1780                 1785             


Gln Lys  Glu Lys Gln Lys Pro  Asp Ile Val Leu Tyr  Pro Glu Pro 
    1790                 1795                 1800             


Val Arg  Val Leu Glu Gly Glu  Thr Ala Arg Phe Arg  Cys Arg Val 
    1805                 1810                 1815             


Thr Gly  Tyr Pro Gln Pro Lys  Val Asn Trp Tyr Leu  Asn Gly Gln 
    1820                 1825                 1830             


Leu Ile  Arg Lys Ser Lys Arg  Phe Arg Val Arg Tyr  Asp Gly Ile 
    1835                 1840                 1845             


His Tyr  Leu Asp Ile Val Asp  Cys Lys Ser Tyr Asp  Thr Gly Glu 
    1850                 1855                 1860             


Val Lys  Val Thr Ala Glu Asn  Pro Glu Gly Val Ile  Glu His Lys 
    1865                 1870                 1875             


Val Lys  Leu Glu Ile Gln Gln  Arg Glu Asp Phe Arg  Ser Val Leu 
    1880                 1885                 1890             


Arg Arg  Ala Pro Glu Pro Arg  Pro Glu Phe His Val  His Glu Pro 
    1895                 1900                 1905             


Gly Lys  Leu Gln Phe Glu Val  Gln Lys Val Asp Arg  Pro Val Asp 
    1910                 1915                 1920             


Thr Thr  Glu Thr Lys Glu Val  Val Lys Leu Lys Arg  Ala Glu Arg 
    1925                 1930                 1935             


Ile Thr  His Glu Lys Val Pro  Glu Glu Ser Glu Glu  Leu Arg Ser 
    1940                 1945                 1950             


Lys Phe  Lys Arg Arg Thr Glu  Glu Gly Tyr Tyr Glu  Ala Ile Thr 
    1955                 1960                 1965             


Ala Val  Glu Leu Lys Ser Arg  Lys Lys Asp Glu Ser  Tyr Glu Glu 
    1970                 1975                 1980             


Leu Leu  Arg Lys Thr Lys Asp  Glu Leu Leu His Trp  Thr Lys Glu 
    1985                 1990                 1995             


Leu Thr  Glu Glu Glu Lys Lys  Ala Leu Ala Glu Glu  Gly Lys Ile 
    2000                 2005                 2010             


Thr Ile  Pro Thr Phe Lys Pro  Asp Lys Ile Glu Leu  Ser Pro Ser 
    2015                 2020                 2025             


Met Glu  Ala Pro Lys Ile Phe  Glu Arg Ile Gln Ser  Gln Thr Val 
    2030                 2035                 2040             


Gly Gln  Gly Ser Asp Ala His  Phe Arg Val Arg Val  Val Gly Lys 
    2045                 2050                 2055             


Pro Asp  Pro Glu Cys Glu Trp  Tyr Lys Asn Gly Val  Lys Ile Glu 
    2060                 2065                 2070             


Arg Ser  Asp Arg Ile Tyr Trp  Tyr Trp Pro Glu Asp  Asn Val Cys 
    2075                 2080                 2085             


Glu Leu  Val Ile Arg Asp Val  Thr Ala Glu Asp Ser  Ala Ser Ile 
    2090                 2095                 2100             


Met Val  Lys Ala Ile Asn Ile  Ala Gly Glu Thr Ser  Ser His Ala 
    2105                 2110                 2115             


Phe Leu  Leu Val Gln Ala Lys  Gln Leu Ile Thr Phe  Thr Gln Glu 
    2120                 2125                 2130             


Leu Gln  Asp Val Val Ala Lys  Glu Lys Asp Thr Met  Ala Thr Phe 
    2135                 2140                 2145             


Glu Cys  Glu Thr Ser Glu Pro  Phe Val Lys Val Lys  Trp Tyr Lys 
    2150                 2155                 2160             


Asp Gly  Met Glu Val His Glu  Gly Asp Lys Tyr Arg  Met His Ser 
    2165                 2170                 2175             


Asp Arg  Lys Val His Phe Leu  Ser Ile Leu Thr Ile  Asp Thr Ser 
    2180                 2185                 2190             


Asp Ala  Glu Asp Tyr Ser Cys  Val Leu Val Glu Asp  Glu Asn Val 
    2195                 2200                 2205             


Lys Thr  Thr Ala Lys Leu Ile  Val Glu Gly Ala Val  Val Glu Phe 
    2210                 2215                 2220             


Val Lys  Glu Leu Gln Asp Ile  Glu Val Pro Glu Ser  Tyr Ser Gly 
    2225                 2230                 2235             


Glu Leu  Glu Cys Ile Val Ser  Pro Glu Asn Ile Glu  Gly Lys Trp 
    2240                 2245                 2250             


Tyr His  Asn Asp Val Glu Leu  Lys Ser Asn Gly Lys  Tyr Thr Ile 
    2255                 2260                 2265             


Thr Ser  Arg Arg Gly Arg Gln  Asn Leu Thr Val Lys  Asp Val Thr 
    2270                 2275                 2280             


Lys Glu  Asp Gln Gly Glu Tyr  Ser Phe Val Ile Asp  Gly Lys Lys 
    2285                 2290                 2295             


Thr Thr  Cys Lys Leu Lys Met  Lys Pro Arg Pro Ile  Ala Ile Leu 
    2300                 2305                 2310             


Gln Gly  Leu Ser Asp Gln Lys  Val Cys Glu Gly Asp  Ile Val Gln 
    2315                 2320                 2325             


Leu Glu  Val Lys Val Ser Leu  Glu Ser Val Glu Gly  Val Trp Met 
    2330                 2335                 2340             


Lys Asp  Gly Gln Glu Val Gln  Pro Ser Asp Arg Val  His Ile Val 
    2345                 2350                 2355             


Ile Asp  Lys Gln Ser His Met  Leu Leu Ile Glu Asp  Met Thr Lys 
    2360                 2365                 2370             


Glu Asp  Ala Gly Asn Tyr Ser  Phe Thr Ile Pro Ala  Leu Gly Leu 
    2375                 2380                 2385             


Ser Thr  Ser Gly Arg Val Ser  Val Tyr Ser Val Asp  Val Ile Thr 
    2390                 2395                 2400             


Pro Leu  Lys Asp Val Asn Val  Ile Glu Gly Thr Lys  Ala Val Leu 
    2405                 2410                 2415             


Glu Cys  Lys Val Ser Val Pro  Asp Val Thr Ser Val  Lys Trp Tyr 
    2420                 2425                 2430             


Leu Asn  Asp Glu Gln Ile Lys  Pro Asp Asp Arg Val  Gln Ala Ile 
    2435                 2440                 2445             


Val Lys  Gly Thr Lys Gln Arg  Leu Val Ile Asn Arg  Thr His Ala 
    2450                 2455                 2460             


Ser Asp  Glu Gly Pro Tyr Lys  Leu Ile Val Gly Arg  Val Glu Thr 
    2465                 2470                 2475             


Asn Cys  Asn Leu Ser Val Glu  Lys Ile Lys Ile Ile  Arg Gly Leu 
    2480                 2485                 2490             


Arg Asp  Leu Thr Cys Thr Glu  Thr Gln Asn Val Val  Phe Glu Val 
    2495                 2500                 2505             


Glu Leu  Ser His Ser Gly Ile  Asp Val Leu Trp Asn  Phe Lys Asp 
    2510                 2515                 2520             


Lys Glu  Ile Lys Pro Ser Ser  Lys Tyr Lys Ile Glu  Ala His Gly 
    2525                 2530                 2535             


Lys Ile  Tyr Lys Leu Thr Val  Leu Asn Met Met Lys  Asp Asp Glu 
    2540                 2545                 2550             


Gly Lys  Tyr Thr Phe Tyr Ala  Gly Glu Asn Ile Thr  Ser Gly Lys 
    2555                 2560                 2565             


Leu Thr  Val Ala Gly Gly Ala  Ile Ser Lys Pro Leu  Thr Asp Gln 
    2570                 2575                 2580             


Thr Val  Ala Glu Ser Gln Glu  Ala Val Phe Glu Cys  Glu Val Ala 
    2585                 2590                 2595             


Asn Pro  Asp Ser Lys Gly Glu  Trp Leu Arg Asp Gly  Lys His Leu 
    2600                 2605                 2610             


Pro Leu  Thr Asn Asn Ile Arg  Ser Glu Ser Asp Gly  His Lys Arg 
    2615                 2620                 2625             


Arg Leu  Ile Ile Ala Ala Thr  Lys Leu Asp Asp Ile  Gly Glu Tyr 
    2630                 2635                 2640             


Thr Tyr  Lys Val Ala Thr Ser  Lys Thr Ser Ala Lys  Leu Lys Val 
    2645                 2650                 2655             


Glu Ala  Val Lys Ile Lys Lys  Thr Leu Lys Asn Leu  Thr Val Thr 
    2660                 2665                 2670             


Glu Thr  Gln Asp Ala Val Phe  Thr Val Glu Leu Thr  His Pro Asn 
    2675                 2680                 2685             


Val Lys  Gly Val Gln Trp Ile  Lys Asn Gly Val Val  Leu Glu Ser 
    2690                 2695                 2700             


Asn Glu  Lys Tyr Ala Ile Ser  Val Lys Gly Thr Ile  Tyr Ser Leu 
    2705                 2710                 2715             


Arg Ile  Lys Asn Cys Ala Ile  Val Asp Glu Ser Val  Tyr Gly Phe 
    2720                 2725                 2730             


Arg Leu  Gly Arg Leu Gly Ala  Ser Ala Arg Leu His  Val Glu Thr 
    2735                 2740                 2745             


Val Lys  Ile Ile Lys Lys Pro  Lys Asp Val Thr Ala  Leu Glu Asn 
    2750                 2755                 2760             


Ala Thr  Val Ala Phe Glu Val  Ser Val Ser His Asp  Thr Val Pro 
    2765                 2770                 2775             


Val Lys  Trp Phe His Lys Asn  Val Glu Ile Lys Pro  Ser Asp Lys 
    2780                 2785                 2790             


His Arg  Leu Val Ser Glu Arg  Lys Val His Lys Leu  Met Leu Gln 
    2795                 2800                 2805             


Asn Ile  Ser Pro Ser Asp Ala  Gly Glu Tyr Thr Ala  Val Val Gly 
    2810                 2815                 2820             


Gln Leu  Glu Cys Lys Ala Lys  Leu Phe Val Glu Thr  Leu His Ile 
    2825                 2830                 2835             


Thr Lys  Thr Met Lys Asn Ile  Glu Val Pro Glu Thr  Lys Thr Ala 
    2840                 2845                 2850             


Ser Phe  Glu Cys Glu Val Ser  His Phe Asn Val Pro  Ser Met Trp 
    2855                 2860                 2865             


Leu Lys  Asn Gly Val Glu Ile  Glu Met Ser Glu Lys  Phe Lys Ile 
    2870                 2875                 2880             


Val Val  Gln Gly Lys Leu His  Gln Leu Ile Ile Met  Asn Thr Ser 
    2885                 2890                 2895             


Thr Glu  Asp Ser Ala Glu Tyr  Thr Phe Val Cys Gly  Asn Asp Gln 
    2900                 2905                 2910             


Val Ser  Ala Thr Leu Thr Val  Thr Pro Ile Met Ile  Thr Ser Met 
    2915                 2920                 2925             


Leu Lys  Asp Ile Asn Ala Glu  Glu Lys Asp Thr Ile  Thr Phe Glu 
    2930                 2935                 2940             


Val Thr  Val Asn Tyr Glu Gly  Ile Ser Tyr Lys Trp  Leu Lys Asn 
    2945                 2950                 2955             


Gly Val  Glu Ile Lys Ser Thr  Asp Lys Cys Gln Met  Arg Thr Lys 
    2960                 2965                 2970             


Lys Leu  Thr His Ser Leu Asn  Ile Arg Asn Val His  Phe Gly Asp 
    2975                 2980                 2985             


Ala Ala  Asp Tyr Thr Phe Val  Ala Gly Lys Ala Thr  Ser Thr Ala 
    2990                 2995                 3000             


Thr Leu  Tyr Val Glu Ala Arg  His Ile Glu Phe Arg  Lys His Ile 
    3005                 3010                 3015             


Lys Asp  Ile Lys Val Leu Glu  Lys Lys Arg Ala Met  Phe Glu Cys 
    3020                 3025                 3030             


Glu Val  Ser Glu Pro Asp Ile  Thr Val Gln Trp Met  Lys Asp Asp 
    3035                 3040                 3045             


Gln Glu  Leu Gln Ile Thr Asp  Arg Ile Lys Ile Gln  Lys Glu Lys 
    3050                 3055                 3060             


Tyr Val  His Arg Leu Leu Ile  Pro Ser Thr Arg Met  Ser Asp Ala 
    3065                 3070                 3075             


Gly Lys  Tyr Thr Val Val Ala  Gly Gly Asn Val Ser  Thr Ala Lys 
    3080                 3085                 3090             


Leu Phe  Val Glu Gly Arg Asp  Val Arg Ile Arg Ser  Ile Lys Lys 
    3095                 3100                 3105             


Glu Val  Gln Val Ile Glu Lys  Gln Arg Ala Val Val  Glu Phe Glu 
    3110                 3115                 3120             


Val Asn  Glu Asp Asp Val Asp  Ala His Trp Tyr Lys  Asp Gly Ile 
    3125                 3130                 3135             


Glu Ile  Asn Phe Gln Val Gln  Glu Arg His Lys Tyr  Val Val Glu 
    3140                 3145                 3150             


Arg Arg  Ile His Arg Met Phe  Ile Ser Glu Thr Arg  Gln Ser Asp 
    3155                 3160                 3165             


Ala Gly  Glu Tyr Thr Phe Val  Ala Gly Arg Asn Arg  Ser Ser Val 
    3170                 3175                 3180             


Thr Leu  Tyr Val Asn Ala Pro  Glu Pro Pro Gln Val  Leu Gln Glu 
    3185                 3190                 3195             


Leu Gln  Pro Val Thr Val Gln  Ser Gly Lys Pro Ala  Arg Phe Cys 
    3200                 3205                 3210             


Ala Val  Ile Ser Gly Arg Pro  Gln Pro Lys Ile Ser  Trp Tyr Lys 
    3215                 3220                 3225             


Glu Glu  Gln Leu Leu Ser Thr  Gly Phe Lys Cys Lys  Phe Leu His 
    3230                 3235                 3240             


Asp Gly  Gln Glu Tyr Thr Leu  Leu Leu Ile Glu Ala  Phe Pro Glu 
    3245                 3250                 3255             


Asp Ala  Ala Val Tyr Thr Cys  Glu Ala Lys Asn Asp  Tyr Gly Val 
    3260                 3265                 3270             


Ala Thr  Thr Ser Ala Ser Leu  Ser Val Glu Val Pro  Glu Val Val 
    3275                 3280                 3285             


Ser Pro  Asp Gln Glu Met Pro  Val Tyr Pro Pro Ala  Ile Ile Thr 
    3290                 3295                 3300             


Pro Leu  Gln Asp Thr Val Thr  Ser Glu Gly Gln Pro  Ala Arg Phe 
    3305                 3310                 3315             


Gln Cys  Arg Val Ser Gly Thr  Asp Leu Lys Val Ser  Trp Tyr Ser 
    3320                 3325                 3330             


Lys Asp  Lys Lys Ile Lys Pro  Ser Arg Phe Phe Arg  Met Thr Gln 
    3335                 3340                 3345             


Phe Glu  Asp Thr Tyr Gln Leu  Glu Ile Ala Glu Ala  Tyr Pro Glu 
    3350                 3355                 3360             


Asp Glu  Gly Thr Tyr Thr Phe  Val Ala Ser Asn Ala  Val Gly Gln 
    3365                 3370                 3375             


Val Ser  Ser Thr Ala Asn Leu  Ser Leu Glu Ala Pro  Glu Ser Ile 
    3380                 3385                 3390             


Leu His  Glu Arg Ile Glu Gln  Glu Ile Glu Met Glu  Met Lys Glu 
    3395                 3400                 3405             


Phe Ser  Ser Ser Phe Leu Ser  Ala Glu Glu Glu Gly  Leu His Ser 
    3410                 3415                 3420             


Ala Glu  Leu Gln Leu Ser Lys  Ile Asn Glu Thr Leu  Glu Leu Leu 
    3425                 3430                 3435             


Ser Glu  Ser Pro Val Tyr Ser  Thr Lys Phe Asp Ser  Glu Lys Glu 
    3440                 3445                 3450             


Gly Thr  Gly Pro Ile Phe Ile  Lys Glu Val Ser Asn  Ala Asp Ile 
    3455                 3460                 3465             


Ser Met  Gly Asp Val Ala Thr  Leu Ser Val Thr Val  Ile Gly Ile 
    3470                 3475                 3480             


Pro Lys  Pro Lys Ile Gln Trp  Phe Phe Asn Gly Val  Leu Leu Thr 
    3485                 3490                 3495             


Pro Ser  Ala Asp Tyr Lys Phe  Val Phe Asp Gly Asp  Asp His Ser 
    3500                 3505                 3510             


Leu Ile  Ile Leu Phe Thr Lys  Leu Glu Asp Glu Gly  Glu Tyr Thr 
    3515                 3520                 3525             


Cys Met  Ala Ser Asn Asp Tyr  Gly Lys Thr Ile Cys  Ser Ala Tyr 
    3530                 3535                 3540             


Leu Lys  Ile Asn Ser Lys Gly  Glu Gly His Lys Asp  Thr Glu Thr 
    3545                 3550                 3555             


Glu Ser  Ala Val Ala Lys Ser  Leu Glu Lys Leu Gly  Gly Pro Cys 
    3560                 3565                 3570             


Pro Pro  His Phe Leu Lys Glu  Leu Lys Pro Ile Arg  Cys Ala Gln 
    3575                 3580                 3585             


Gly Leu  Pro Ala Ile Phe Glu  Tyr Thr Val Val Gly  Glu Pro Ala 
    3590                 3595                 3600             


Pro Thr  Val Thr Trp Phe Lys  Glu Asn Lys Gln Leu  Cys Thr Ser 
    3605                 3610                 3615             


Val Tyr  Tyr Thr Ile Ile His  Asn Pro Asn Gly Ser  Gly Thr Phe 
    3620                 3625                 3630             


Ile Val  Asn Asp Pro Gln Arg  Glu Asp Ser Gly Leu  Tyr Ile Cys 
    3635                 3640                 3645             


Lys Ala  Glu Asn Met Leu Gly  Glu Ser Thr Cys Ala  Ala Glu Leu 
    3650                 3655                 3660             


Leu Val  Leu Leu Glu Asp Thr  Asp Met Thr Asp Thr  Pro Cys Lys 
    3665                 3670                 3675             


Ala Lys  Ser Thr Pro Glu Ala  Pro Glu Asp Phe Pro  Gln Thr Pro 
    3680                 3685                 3690             


Leu Lys  Gly Pro Ala Val Glu  Ala Leu Asp Ser Glu  Gln Glu Ile 
    3695                 3700                 3705             


Ala Thr  Phe Val Lys Asp Thr  Ile Leu Lys Ala Ala  Leu Ile Thr 
    3710                 3715                 3720             


Glu Glu  Asn Gln Gln Leu Ser  Tyr Glu His Ile Ala  Lys Ala Asn 
    3725                 3730                 3735             


Glu Leu  Ser Ser Gln Leu Pro  Leu Gly Ala Gln Glu  Leu Gln Ser 
    3740                 3745                 3750             


Ile Leu  Glu Gln Asp Lys Leu  Thr Pro Glu Ser Thr  Arg Glu Phe 
    3755                 3760                 3765             


Leu Cys  Ile Asn Gly Ser Ile  His Phe Gln Pro Leu  Lys Glu Pro 
    3770                 3775                 3780             


Ser Pro  Asn Leu Gln Leu Gln  Ile Val Gln Ser Gln  Lys Thr Phe 
    3785                 3790                 3795             


Ser Lys  Glu Gly Ile Leu Met  Pro Glu Glu Pro Glu  Thr Gln Ala 
    3800                 3805                 3810             


Val Leu  Ser Asp Thr Glu Lys  Ile Phe Pro Ser Ala  Met Ser Ile 
    3815                 3820                 3825             


Glu Gln  Ile Asn Ser Leu Thr  Val Glu Pro Leu Lys  Thr Leu Leu 
    3830                 3835                 3840             


Ala Glu  Pro Glu Gly Asn Tyr  Pro Gln Ser Ser Ile  Glu Pro Pro 
    3845                 3850                 3855             


Met His  Ser Tyr Leu Thr Ser  Val Ala Glu Glu Val  Leu Ser Pro 
    3860                 3865                 3870             


Lys Glu  Lys Thr Val Ser Asp  Thr Asn Arg Glu Gln  Arg Val Thr 
    3875                 3880                 3885             


Leu Gln  Lys Gln Glu Ala Gln  Ser Ala Leu Ile Leu  Ser Gln Ser 
    3890                 3895                 3900             


Leu Ala  Glu Gly His Val Glu  Ser Leu Gln Ser Pro  Asp Val Met 
    3905                 3910                 3915             


Ile Ser  Gln Val Asn Tyr Glu  Pro Leu Val Pro Ser  Glu His Ser 
    3920                 3925                 3930             


Cys Thr  Glu Gly Gly Lys Ile  Leu Ile Glu Ser Ala  Asn Pro Leu 
    3935                 3940                 3945             


Glu Asn  Ala Gly Gln Asp Ser  Ala Val Arg Ile Glu  Glu Gly Lys 
    3950                 3955                 3960             


Ser Leu  Arg Phe Pro Leu Ala  Leu Glu Glu Lys Gln  Val Leu Leu 
    3965                 3970                 3975             


Lys Glu  Glu His Ser Asp Asn  Val Val Met Pro Pro  Asp Gln Ile 
    3980                 3985                 3990             


Ile Glu  Ser Lys Arg Glu Pro  Val Ala Ile Lys Lys  Val Gln Glu 
    3995                 4000                 4005             


Val Gln  Gly Arg Asp Leu Leu  Ser Lys Glu Ser Leu  Leu Ser Gly 
    4010                 4015                 4020             


Ile Pro  Glu Glu Gln Arg Leu  Asn Leu Lys Ile Gln  Ile Cys Arg 
    4025                 4030                 4035             


Ala Leu  Gln Ala Ala Val Ala  Ser Glu Gln Pro Gly  Leu Phe Ser 
    4040                 4045                 4050             


Glu Trp  Leu Arg Asn Ile Glu  Lys Val Glu Val Glu  Ala Val Asn 
    4055                 4060                 4065             


Ile Thr  Gln Glu Pro Arg His  Ile Met Cys Met Tyr  Leu Val Thr 
    4070                 4075                 4080             


Ser Ala  Lys Ser Val Thr Glu  Glu Val Thr Ile Ile  Ile Glu Asp 
    4085                 4090                 4095             


Val Asp  Pro Gln Met Ala Asn  Leu Lys Met Glu Leu  Arg Asp Ala 
    4100                 4105                 4110             


Leu Cys  Ala Ile Ile Tyr Glu  Glu Ile Asp Ile Leu  Thr Ala Glu 
    4115                 4120                 4125             


Gly Pro  Arg Ile Gln Gln Gly  Ala Lys Thr Ser Leu  Gln Glu Glu 
    4130                 4135                 4140             


Met Asp  Ser Phe Ser Gly Ser  Gln Lys Val Glu Pro  Ile Thr Glu 
    4145                 4150                 4155             


Pro Glu  Val Glu Ser Lys Tyr  Leu Ile Ser Pro Glu  Glu Val Ser 
    4160                 4165                 4170             


Tyr Phe  Asn Val Gln Ser Arg  Val Lys Tyr Leu Asp  Ala Thr Pro 
    4175                 4180                 4185             


Val Thr  Lys Gly Val Ala Ser  Ala Val Val Ser Asp  Glu Lys Gln 
    4190                 4195                 4200             


Asp Glu  Ser Leu Lys Pro Ser  Glu Glu Lys Glu Glu  Ser Ser Ser 
    4205                 4210                 4215             


Glu Ser  Gly Thr Glu Glu Val  Ala Thr Val Lys Ile  Gln Glu Ala 
    4220                 4225                 4230             


Glu Gly  Gly Phe Ile Lys Glu  Asp Gly Pro Met Ile  His Thr Pro 
    4235                 4240                 4245             


Leu Val  Asp Thr Val Ser Glu  Glu Gly Asp Ile Val  His Leu Thr 
    4250                 4255                 4260             


Thr Ser  Ile Thr Asn Ala Lys  Glu Val Asn Trp Tyr  Phe Glu Asn 
    4265                 4270                 4275             


Lys Leu  Val Pro Ser Asp Glu  Lys Phe Lys Cys Leu  Gln Asp Gln 
    4280                 4285                 4290             


Asn Thr  Tyr Thr Leu Val Ile  Asp Lys Val Asn Thr  Glu Asp His 
    4295                 4300                 4305             


Gln Gly  Glu Tyr Val Cys Glu  Ala Leu Asn Asp Ser  Gly Lys Thr 
    4310                 4315                 4320             


Ala Thr  Ser Ala Lys Leu Thr  Val Val Lys Arg Ala  Ala Pro Val 
    4325                 4330                 4335             


Ile Lys  Arg Lys Ile Glu Pro  Leu Glu Val Ala Leu  Gly His Leu 
    4340                 4345                 4350             


Ala Lys  Phe Thr Cys Glu Ile  Gln Ser Ala Pro Asn  Val Arg Phe 
    4355                 4360                 4365             


Gln Trp  Phe Lys Ala Gly Arg  Glu Ile Tyr Glu Ser  Asp Lys Cys 
    4370                 4375                 4380             


Ser Ile  Arg Ser Ser Lys Tyr  Ile Ser Ser Leu Glu  Ile Leu Arg 
    4385                 4390                 4395             


Thr Gln  Val Val Asp Cys Gly  Glu Tyr Thr Cys Lys  Ala Ser Asn 
    4400                 4405                 4410             


Glu Tyr  Gly Ser Val Ser Cys  Thr Ala Thr Leu Thr  Val Thr Val 
    4415                 4420                 4425             


Pro Gly  Gly Glu Lys Lys Val  Arg Lys Leu Leu Pro  Glu Arg Lys 
    4430                 4435                 4440             


Pro Glu  Pro Lys Glu Glu Val  Val Leu Lys Ser Val  Leu Arg Lys 
    4445                 4450                 4455             


Arg Pro  Glu Glu Glu Glu Pro  Lys Val Glu Pro Lys  Lys Leu Glu 
    4460                 4465                 4470             


Lys Val  Lys Lys Pro Ala Val  Pro Glu Pro Pro Pro  Pro Lys Pro 
    4475                 4480                 4485             


Val Glu  Glu Val Glu Val Pro  Thr Val Thr Lys Arg  Glu Arg Lys 
    4490                 4495                 4500             


Ile Pro  Glu Pro Thr Lys Val  Pro Glu Ile Lys Pro  Ala Ile Pro 
    4505                 4510                 4515             


Leu Pro  Ala Pro Glu Pro Lys  Pro Lys Pro Glu Ala  Glu Val Lys 
    4520                 4525                 4530             


Thr Ile  Lys Pro Pro Pro Val  Glu Pro Glu Pro Thr  Pro Ile Ala 
    4535                 4540                 4545             


Ala Pro  Val Thr Val Pro Val  Val Gly Lys Lys Ala  Glu Ala Lys 
    4550                 4555                 4560             


Ala Pro  Lys Glu Glu Ala Ala  Lys Pro Lys Gly Pro  Ile Lys Gly 
    4565                 4570                 4575             


Val Pro  Lys Lys Thr Pro Ser  Pro Ile Glu Ala Glu  Arg Arg Lys 
    4580                 4585                 4590             


Leu Arg  Pro Gly Ser Gly Gly  Glu Lys Pro Pro Asp  Glu Ala Pro 
    4595                 4600                 4605             


Phe Thr  Tyr Gln Leu Lys Ala  Val Pro Leu Lys Phe  Val Lys Glu 
    4610                 4615                 4620             


Ile Lys  Asp Ile Ile Leu Thr  Glu Ser Glu Phe Val  Gly Ser Ser 
    4625                 4630                 4635             


Ala Ile  Phe Glu Cys Leu Val  Ser Pro Ser Thr Ala  Ile Thr Thr 
    4640                 4645                 4650             


Trp Met  Lys Asp Gly Ser Asn  Ile Arg Glu Ser Pro  Lys His Arg 
    4655                 4660                 4665             


Phe Ile  Ala Asp Gly Lys Asp  Arg Lys Leu His Ile  Ile Asp Val 
    4670                 4675                 4680             


Gln Leu  Ser Asp Ala Gly Glu  Tyr Thr Cys Val Leu  Arg Leu Gly 
    4685                 4690                 4695             


Asn Lys  Glu Lys Thr Ser Thr  Ala Lys Leu Val Val  Glu Glu Leu 
    4700                 4705                 4710             


Pro Val  Arg Phe Val Lys Thr  Leu Glu Glu Glu Val  Thr Val Val 
    4715                 4720                 4725             


Lys Gly  Gln Pro Leu Tyr Leu  Ser Cys Glu Leu Asn  Lys Glu Arg 
    4730                 4735                 4740             


Asp Val  Val Trp Arg Lys Asp  Gly Lys Ile Val Val  Glu Lys Pro 
    4745                 4750                 4755             


Gly Arg  Ile Val Pro Gly Val  Ile Gly Leu Met Arg  Ala Leu Thr 
    4760                 4765                 4770             


Ile Asn  Asp Ala Asp Asp Thr  Asp Ala Gly Thr Tyr  Thr Val Thr 
    4775                 4780                 4785             


Val Glu  Asn Ala Asn Asn Leu  Glu Cys Ser Ser Cys  Val Lys Val 
    4790                 4795                 4800             


Val Glu  Val Ile Arg Asp Trp  Leu Val Lys Pro Ile  Arg Asp Gln 
    4805                 4810                 4815             


His Val  Lys Pro Lys Gly Thr  Ala Ile Phe Ala Cys  Asp Ile Ala 
    4820                 4825                 4830             


Lys Asp  Thr Pro Asn Ile Lys  Trp Phe Lys Gly Tyr  Asp Glu Ile 
    4835                 4840                 4845             


Pro Ala  Glu Pro Asn Asp Lys  Thr Glu Ile Leu Arg  Asp Gly Asn 
    4850                 4855                 4860             


His Leu  Tyr Leu Lys Ile Lys  Asn Ala Met Pro Glu  Asp Ile Ala 
    4865                 4870                 4875             


Glu Tyr  Ala Val Glu Ile Glu  Gly Lys Arg Tyr Pro  Ala Lys Leu 
    4880                 4885                 4890             


Thr Leu  Gly Glu Arg Glu Val  Glu Leu Leu Lys Pro  Ile Glu Asp 
    4895                 4900                 4905             


Val Thr  Ile Tyr Glu Lys Glu  Ser Ala Ser Phe Asp  Ala Glu Ile 
    4910                 4915                 4920             


Ser Glu  Ala Asp Ile Pro Gly  Gln Trp Lys Leu Lys  Gly Glu Leu 
    4925                 4930                 4935             


Leu Arg  Pro Ser Pro Thr Cys  Glu Ile Lys Ala Glu  Gly Gly Lys 
    4940                 4945                 4950             


Arg Phe  Leu Thr Leu Arg Lys  Val Lys Leu Asp Gln  Ala Gly Glu 
    4955                 4960                 4965             


Val Leu  Tyr Gln Ala Leu Asn  Ala Ile Thr Thr Ala  Ile Leu Thr 
    4970                 4975                 4980             


Val Lys  Glu Ile Glu Leu Asp  Phe Ala Val Pro Leu  Lys Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Arg Arg Gln  Ala Arg Phe Glu Cys  Val Leu Thr 
    5000                 5005                 5010             


Arg Glu  Ala Asn Val Ile Trp  Ser Lys Gly Pro Asp  Ile Ile Lys 
    5015                 5020                 5025             


Ser Ser  Asp Lys Phe Asp Ile  Ile Ala Asp Gly Lys  Lys His Ile 
    5030                 5035                 5040             


Leu Val  Ile Asn Asp Ser Gln  Phe Asp Asp Glu Gly  Val Tyr Thr 
    5045                 5050                 5055             


Ala Glu  Val Glu Gly Lys Lys  Thr Ser Ala Arg Leu  Phe Val Thr 
    5060                 5065                 5070             


Gly Ile  Arg Leu Lys Phe Met  Ser Pro Leu Glu Asp  Gln Thr Val 
    5075                 5080                 5085             


Lys Glu  Gly Glu Thr Ala Thr  Phe Val Cys Glu Leu  Ser His Glu 
    5090                 5095                 5100             


Lys Met  His Val Val Trp Phe  Lys Asn Asp Ala Lys  Leu His Thr 
    5105                 5110                 5115             


Ser Arg  Thr Val Leu Ile Ser  Ser Glu Gly Lys Thr  His Lys Leu 
    5120                 5125                 5130             


Glu Met  Lys Glu Val Thr Leu  Asp Asp Ile Ser Gln  Ile Lys Ala 
    5135                 5140                 5145             


Gln Val  Lys Glu Leu Ser Ser  Thr Ala Gln Leu Lys  Val Leu Glu 
    5150                 5155                 5160             


Ala Asp  Pro Tyr Phe Thr Val  Lys Leu His Asp Lys  Thr Ala Val 
    5165                 5170                 5175             


Glu Lys  Asp Glu Ile Thr Leu  Lys Cys Glu Val Ser  Lys Asp Val 
    5180                 5185                 5190             


Pro Val  Lys Trp Phe Lys Asp  Gly Glu Glu Ile Val  Pro Ser Pro 
    5195                 5200                 5205             


Lys Tyr  Ser Ile Lys Ala Asp  Gly Leu Arg Arg Ile  Leu Lys Ile 
    5210                 5215                 5220             


Lys Lys  Ala Asp Leu Lys Asp  Lys Gly Glu Tyr Val  Cys Asp Cys 
    5225                 5230                 5235             


Gly Thr  Asp Lys Thr Lys Ala  Asn Val Thr Val Glu  Ala Arg Leu 
    5240                 5245                 5250             


Ile Lys  Val Glu Lys Pro Leu  Tyr Gly Val Glu Val  Phe Val Gly 
    5255                 5260                 5265             


Glu Thr  Ala His Phe Glu Ile  Glu Leu Ser Glu Pro  Asp Val His 
    5270                 5275                 5280             


Gly Gln  Trp Lys Leu Lys Gly  Gln Pro Leu Thr Ala  Ser Pro Asp 
    5285                 5290                 5295             


Cys Glu  Ile Ile Glu Asp Gly  Lys Lys His Ile Leu  Ile Leu His 
    5300                 5305                 5310             


Asn Cys  Gln Leu Gly Met Thr  Gly Glu Val Ser Phe  Gln Ala Ala 
    5315                 5320                 5325             


Asn Ala  Lys Ser Ala Ala Asn  Leu Lys Val Lys Glu  Leu Pro Leu 
    5330                 5335                 5340             


Ile Phe  Ile Thr Pro Leu Ser  Asp Val Lys Val Phe  Glu Lys Asp 
    5345                 5350                 5355             


Glu Ala  Lys Phe Glu Cys Glu  Val Ser Arg Glu Pro  Lys Thr Phe 
    5360                 5365                 5370             


Arg Trp  Leu Lys Gly Thr Gln  Glu Ile Thr Gly Asp  Asp Arg Phe 
    5375                 5380                 5385             


Glu Leu  Ile Lys Asp Gly Thr  Lys His Ser Met Val  Ile Lys Ser 
    5390                 5395                 5400             


Ala Ala  Phe Glu Asp Glu Ala  Lys Tyr Met Phe Glu  Ala Glu Asp 
    5405                 5410                 5415             


Lys His  Thr Ser Gly Lys Leu  Ile Ile Glu Gly Ile  Arg Leu Lys 
    5420                 5425                 5430             


Phe Leu  Thr Pro Leu Lys Asp  Val Thr Ala Lys Glu  Lys Glu Ser 
    5435                 5440                 5445             


Ala Val  Phe Thr Val Glu Leu  Ser His Asp Asn Ile  Arg Val Lys 
    5450                 5455                 5460             


Trp Phe  Lys Asn Asp Gln Arg  Leu His Thr Thr Arg  Ser Val Ser 
    5465                 5470                 5475             


Met Gln  Asp Glu Gly Lys Thr  His Ser Ile Thr Phe  Lys Asp Leu 
    5480                 5485                 5490             


Ser Ile  Asp Asp Thr Ser Gln  Ile Arg Val Glu Ala  Met Gly Met 
    5495                 5500                 5505             


Ser Ser  Glu Ala Lys Leu Thr  Val Leu Glu Gly Asp  Pro Tyr Phe 
    5510                 5515                 5520             


Thr Gly  Lys Leu Gln Asp Tyr  Thr Gly Val Glu Lys  Asp Glu Val 
    5525                 5530                 5535             


Ile Leu  Gln Cys Glu Ile Ser  Lys Ala Asp Ala Pro  Val Lys Trp 
    5540                 5545                 5550             


Phe Lys  Asp Gly Lys Glu Ile  Lys Pro Ser Lys Asn  Ala Val Ile 
    5555                 5560                 5565             


Lys Ala  Asp Gly Lys Lys Arg  Met Leu Ile Leu Lys  Lys Ala Leu 
    5570                 5575                 5580             


Lys Ser  Asp Ile Gly Gln Tyr  Thr Cys Asp Cys Gly  Thr Asp Lys 
    5585                 5590                 5595             


Thr Ser  Gly Lys Leu Asp Ile  Glu Asp Arg Glu Ile  Lys Leu Val 
    5600                 5605                 5610             


Arg Pro  Leu His Ser Val Glu  Val Met Glu Thr Glu  Thr Ala Arg 
    5615                 5620                 5625             


Phe Glu  Thr Glu Ile Ser Glu  Asp Asp Ile His Ala  Asn Trp Lys 
    5630                 5635                 5640             


Leu Lys  Gly Glu Ala Leu Leu  Gln Thr Pro Asp Cys  Glu Ile Lys 
    5645                 5650                 5655             


Glu Glu  Gly Lys Ile His Ser  Leu Val Leu His Asn  Cys Arg Leu 
    5660                 5665                 5670             


Asp Gln  Thr Gly Gly Val Asp  Phe Gln Ala Ala Asn  Val Lys Ser 
    5675                 5680                 5685             


Ser Ala  His Leu Arg Val Lys  Pro Arg Val Ile Gly  Leu Leu Arg 
    5690                 5695                 5700             


Pro Leu  Lys Asp Val Thr Val  Thr Ala Gly Glu Thr  Ala Thr Phe 
    5705                 5710                 5715             


Asp Cys  Glu Leu Ser Tyr Glu  Asp Ile Pro Val Glu  Trp Tyr Leu 
    5720                 5725                 5730             


Lys Gly  Lys Lys Leu Glu Pro  Ser Asp Lys Val Val  Pro Arg Ser 
    5735                 5740                 5745             


Glu Gly  Lys Val His Thr Leu  Thr Leu Arg Asp Val  Lys Leu Glu 
    5750                 5755                 5760             


Asp Ala  Gly Glu Val Gln Leu  Thr Ala Lys Asp Phe  Lys Thr His 
    5765                 5770                 5775             


Ala Asn  Leu Phe Val Lys Glu  Pro Pro Val Glu Phe  Thr Lys Pro 
    5780                 5785                 5790             


Leu Glu  Asp Gln Thr Val Glu  Glu Gly Ala Thr Ala  Val Leu Glu 
    5795                 5800                 5805             


Cys Glu  Val Ser Arg Glu Asn  Ala Lys Val Lys Trp  Phe Lys Asn 
    5810                 5815                 5820             


Gly Thr  Glu Ile Leu Lys Ser  Lys Lys Tyr Glu Ile  Val Ala Asp 
    5825                 5830                 5835             


Gly Arg  Val Arg Lys Leu Val  Ile His Asp Cys Thr  Pro Glu Asp 
    5840                 5845                 5850             


Ile Lys  Thr Tyr Thr Cys Asp  Ala Lys Asp Phe Lys  Thr Ser Cys 
    5855                 5860                 5865             


Asn Leu  Asn Val Val Pro Pro  His Val Glu Phe Leu  Arg Pro Leu 
    5870                 5875                 5880             


Thr Asp  Leu Gln Val Arg Glu  Lys Glu Met Ala Arg  Phe Glu Cys 
    5885                 5890                 5895             


Glu Leu  Ser Arg Glu Asn Ala  Lys Val Lys Trp Phe  Lys Asp Gly 
    5900                 5905                 5910             


Ala Glu  Ile Lys Lys Gly Lys  Lys Tyr Asp Ile Ile  Ser Lys Gly 
    5915                 5920                 5925             


Ala Val  Arg Ile Leu Val Ile  Asn Lys Cys Leu Leu  Asp Asp Glu 
    5930                 5935                 5940             


Ala Glu  Tyr Ser Cys Glu Val  Arg Thr Ala Arg Thr  Ser Gly Met 
    5945                 5950                 5955             


Leu Thr  Val Leu Glu Glu Glu  Ala Val Phe Thr Lys  Asn Leu Ala 
    5960                 5965                 5970             


Asn Ile  Glu Val Ser Glu Thr  Asp Thr Ile Lys Leu  Val Cys Glu 
    5975                 5980                 5985             


Val Ser  Lys Pro Gly Ala Glu  Val Ile Trp Tyr Lys  Gly Asp Glu 
    5990                 5995                 6000             


Glu Ile  Ile Glu Thr Gly Arg  Tyr Glu Ile Leu Thr  Glu Gly Arg 
    6005                 6010                 6015             


Lys Arg  Ile Leu Val Ile Gln  Asn Ala His Leu Glu  Asp Ala Gly 
    6020                 6025                 6030             


Asn Tyr  Asn Cys Arg Leu Pro  Ser Ser Arg Thr Asp  Gly Lys Val 
    6035                 6040                 6045             


Lys Val  His Glu Leu Ala Ala  Glu Phe Ile Ser Lys  Pro Gln Asn 
    6050                 6055                 6060             


Leu Glu  Ile Leu Glu Gly Glu  Lys Ala Glu Phe Val  Cys Ser Ile 
    6065                 6070                 6075             


Ser Lys  Glu Ser Phe Pro Val  Gln Trp Lys Arg Asp  Asp Lys Thr 
    6080                 6085                 6090             


Leu Glu  Ser Gly Asp Lys Tyr  Asp Val Ile Ala Asp  Gly Lys Lys 
    6095                 6100                 6105             


Arg Val  Leu Val Val Lys Asp  Ala Thr Leu Gln Asp  Met Gly Thr 
    6110                 6115                 6120             


Tyr Val  Val Met Val Gly Ala  Ala Arg Ala Ala Ala  His Leu Thr 
    6125                 6130                 6135             


Val Ile  Glu Lys Leu Arg Ile  Val Val Pro Leu Lys  Asp Thr Arg 
    6140                 6145                 6150             


Val Lys  Glu Gln Gln Glu Val  Val Phe Asn Cys Glu  Val Asn Thr 
    6155                 6160                 6165             


Glu Gly  Ala Lys Ala Lys Trp  Phe Arg Asn Glu Glu  Ala Ile Phe 
    6170                 6175                 6180             


Asp Ser  Ser Lys Tyr Ile Ile  Leu Gln Lys Asp Leu  Val Tyr Thr 
    6185                 6190                 6195             


Leu Arg  Ile Arg Asp Ala His  Leu Asp Asp Gln Ala  Asn Tyr Asn 
    6200                 6205                 6210             


Val Ser  Leu Thr Asn His Arg  Gly Glu Asn Val Lys  Ser Ala Ala 
    6215                 6220                 6225             


Asn Leu  Ile Val Glu Glu Glu  Asp Leu Arg Ile Val  Glu Pro Leu 
    6230                 6235                 6240             


Lys Asp  Ile Glu Thr Met Glu  Lys Lys Ser Val Thr  Phe Trp Cys 
    6245                 6250                 6255             


Lys Val  Asn Arg Leu Asn Val  Thr Leu Lys Trp Thr  Lys Asn Gly 
    6260                 6265                 6270             


Glu Glu  Val Pro Phe Asp Asn  Arg Val Ser Tyr Arg  Val Asp Lys 
    6275                 6280                 6285             


Tyr Lys  His Met Leu Thr Ile  Lys Asp Cys Gly Phe  Pro Asp Glu 
    6290                 6295                 6300             


Gly Glu  Tyr Ile Val Thr Ala  Gly Gln Asp Lys Ser  Val Ala Glu 
    6305                 6310                 6315             


Leu Leu  Ile Ile Glu Ala Pro  Thr Glu Phe Val Glu  His Leu Glu 
    6320                 6325                 6330             


Asp Gln  Thr Val Thr Glu Phe  Asp Asp Ala Val Phe  Ser Cys Gln 
    6335                 6340                 6345             


Leu Ser  Arg Glu Lys Ala Asn  Val Lys Trp Tyr Arg  Asn Gly Arg 
    6350                 6355                 6360             


Glu Ile  Lys Glu Gly Lys Lys  Tyr Lys Phe Glu Lys  Asp Gly Ser 
    6365                 6370                 6375             


Ile His  Arg Leu Ile Ile Lys  Asp Cys Arg Leu Asp  Asp Glu Cys 
    6380                 6385                 6390             


Glu Tyr  Ala Cys Gly Val Glu  Asp Arg Lys Ser Arg  Ala Arg Leu 
    6395                 6400                 6405             


Phe Val  Glu Glu Ile Pro Val  Glu Ile Ile Arg Pro  Pro Gln Asp 
    6410                 6415                 6420             


Ile Leu  Glu Ala Pro Gly Ala  Asp Val Val Phe Leu  Ala Glu Leu 
    6425                 6430                 6435             


Asn Lys  Asp Lys Val Glu Val  Gln Trp Leu Arg Asn  Asn Met Val 
    6440                 6445                 6450             


Val Val  Gln Gly Asp Lys His  Gln Met Met Ser Glu  Gly Lys Ile 
    6455                 6460                 6465             


His Arg  Leu Gln Ile Cys Asp  Ile Lys Pro Arg Asp  Gln Gly Glu 
    6470                 6475                 6480             


Tyr Arg  Phe Ile Ala Lys Asp  Lys Glu Ala Arg Ala  Lys Leu Glu 
    6485                 6490                 6495             


Leu Ala  Ala Ala Pro Lys Ile  Lys Thr Ala Asp Gln  Asp Leu Val 
    6500                 6505                 6510             


Val Asp  Val Gly Lys Pro Leu  Thr Met Val Val Pro  Tyr Asp Ala 
    6515                 6520                 6525             


Tyr Pro  Lys Ala Glu Ala Glu  Trp Phe Lys Glu Asn  Glu Pro Leu 
    6530                 6535                 6540             


Ser Thr  Lys Thr Ile Asp Thr  Thr Ala Glu Gln Thr  Ser Phe Arg 
    6545                 6550                 6555             


Ile Leu  Glu Ala Lys Lys Gly  Asp Lys Gly Arg Tyr  Lys Ile Val 
    6560                 6565                 6570             


Leu Gln  Asn Lys His Gly Lys  Ala Glu Gly Phe Ile  Asn Leu Lys 
    6575                 6580                 6585             


Val Ile  Asp Val Pro Gly Pro  Val Arg Asn Leu Glu  Val Thr Glu 
    6590                 6595                 6600             


Thr Phe  Asp Gly Glu Val Ser  Leu Ala Trp Glu Glu  Pro Leu Thr 
    6605                 6610                 6615             


Asp Gly  Gly Ser Lys Ile Ile  Gly Tyr Val Val Glu  Arg Arg Asp 
    6620                 6625                 6630             


Ile Lys  Arg Lys Thr Trp Val  Leu Ala Thr Asp Arg  Ala Glu Ser 
    6635                 6640                 6645             


Cys Glu  Phe Thr Val Thr Gly  Leu Gln Lys Gly Gly  Val Glu Tyr 
    6650                 6655                 6660             


Leu Phe  Arg Val Ser Ala Arg  Asn Arg Val Gly Thr  Gly Glu Pro 
    6665                 6670                 6675             


Val Glu  Thr Asp Asn Pro Val  Glu Ala Arg Ser Lys  Tyr Asp Val 
    6680                 6685                 6690             


Pro Gly  Pro Pro Leu Asn Val  Thr Ile Thr Asp Val  Asn Arg Phe 
    6695                 6700                 6705             


Gly Val  Ser Leu Thr Trp Glu  Pro Pro Glu Tyr Asp  Gly Gly Ala 
    6710                 6715                 6720             


Glu Ile  Thr Asn Tyr Val Ile  Glu Leu Arg Asp Lys  Thr Ser Ile 
    6725                 6730                 6735             


Arg Trp  Asp Thr Ala Met Thr  Val Arg Ala Glu Asp  Leu Ser Ala 
    6740                 6745                 6750             


Thr Val  Thr Asp Val Val Glu  Gly Gln Glu Tyr Ser  Phe Arg Val 
    6755                 6760                 6765             


Arg Ala  Gln Asn Arg Ile Gly  Val Gly Lys Pro Ser  Ala Ala Thr 
    6770                 6775                 6780             


Pro Phe  Val Lys Val Ala Asp  Pro Ile Glu Arg Pro  Ser Pro Pro 
    6785                 6790                 6795             


Val Asn  Leu Thr Ser Ser Asp  Gln Thr Gln Ser Ser  Val Gln Leu 
    6800                 6805                 6810             


Lys Trp  Glu Pro Pro Leu Lys  Asp Gly Gly Ser Pro  Ile Leu Gly 
    6815                 6820                 6825             


Tyr Ile  Ile Glu Arg Cys Glu  Glu Gly Lys Asp Asn  Trp Ile Arg 
    6830                 6835                 6840             


Cys Asn  Met Lys Leu Val Pro  Glu Leu Thr Tyr Lys  Val Thr Gly 
    6845                 6850                 6855             


Leu Glu  Lys Gly Asn Lys Tyr  Leu Tyr Arg Val Ser  Ala Glu Asn 
    6860                 6865                 6870             


Lys Ala  Gly Val Ser Asp Pro  Ser Glu Ile Leu Gly  Pro Leu Thr 
    6875                 6880                 6885             


Ala Asp  Asp Ala Phe Val Glu  Pro Thr Met Asp Leu  Ser Ala Phe 
    6890                 6895                 6900             


Lys Asp  Gly Leu Glu Val Ile  Val Pro Asn Pro Ile  Thr Ile Leu 
    6905                 6910                 6915             


Val Pro  Ser Thr Gly Tyr Pro  Arg Pro Thr Ala Thr  Trp Cys Phe 
    6920                 6925                 6930             


Gly Asp  Lys Val Leu Glu Thr  Gly Asp Arg Val Lys  Met Lys Thr 
    6935                 6940                 6945             


Leu Ser  Ala Tyr Ala Glu Leu  Val Ile Ser Pro Ser  Glu Arg Ser 
    6950                 6955                 6960             


Asp Lys  Gly Ile Tyr Thr Leu  Lys Leu Glu Asn Arg  Val Lys Thr 
    6965                 6970                 6975             


Ile Ser  Gly Glu Ile Asp Val  Asn Val Ile Ala Arg  Pro Ser Ala 
    6980                 6985                 6990             


Pro Lys  Glu Leu Lys Phe Gly  Asp Ile Thr Lys Asp  Ser Val His 
    6995                 7000                 7005             


Leu Thr  Trp Glu Pro Pro Asp  Asp Asp Gly Gly Ser  Pro Leu Thr 
    7010                 7015                 7020             


Gly Tyr  Val Val Glu Lys Arg  Glu Val Ser Arg Lys  Thr Trp Thr 
    7025                 7030                 7035             


Lys Val  Met Asp Phe Val Thr  Asp Leu Glu Phe Thr  Val Pro Asp 
    7040                 7045                 7050             


Leu Val  Gln Gly Lys Glu Tyr  Leu Phe Lys Val Cys  Ala Arg Asn 
    7055                 7060                 7065             


Lys Cys  Gly Pro Gly Glu Pro  Ala Tyr Val Asp Glu  Pro Val Asn 
    7070                 7075                 7080             


Met Ser  Thr Pro Ala Thr Val  Pro Asp Pro Pro Glu  Asn Val Lys 
    7085                 7090                 7095             


Trp Arg  Asp Arg Thr Ala Asn  Ser Ile Phe Leu Thr  Trp Asp Pro 
    7100                 7105                 7110             


Pro Lys  Asn Asp Gly Gly Ser  Arg Ile Lys Gly Tyr  Ile Val Glu 
    7115                 7120                 7125             


Arg Cys  Pro Arg Gly Ser Asp  Lys Trp Val Ala Cys  Gly Glu Pro 
    7130                 7135                 7140             


Val Ala  Glu Thr Lys Met Glu  Val Thr Gly Leu Glu  Glu Gly Lys 
    7145                 7150                 7155             


Trp Tyr  Ala Tyr Arg Val Lys  Ala Leu Asn Arg Gln  Gly Ala Ser 
    7160                 7165                 7170             


Lys Pro  Ser Arg Pro Thr Glu  Glu Ile Gln Ala Val  Asp Thr Gln 
    7175                 7180                 7185             


Glu Ala  Pro Glu Ile Phe Leu  Asp Val Lys Leu Leu  Ala Gly Leu 
    7190                 7195                 7200             


Thr Val  Lys Ala Gly Thr Lys  Ile Glu Leu Pro Ala  Thr Val Thr 
    7205                 7210                 7215             


Gly Lys  Pro Glu Pro Lys Ile  Thr Trp Thr Lys Ala  Asp Met Ile 
    7220                 7225                 7230             


Leu Lys  Gln Asp Lys Arg Ile  Thr Ile Glu Asn Val  Pro Lys Lys 
    7235                 7240                 7245             


Ser Thr  Val Thr Ile Val Asp  Ser Lys Arg Ser Asp  Thr Gly Thr 
    7250                 7255                 7260             


Tyr Ile  Ile Glu Ala Val Asn  Val Cys Gly Arg Ala  Thr Ala Val 
    7265                 7270                 7275             


Val Glu  Val Asn Val Leu Asp  Lys Pro Gly Pro Pro  Ala Ala Phe 
    7280                 7285                 7290             


Asp Ile  Thr Asp Val Thr Asn  Glu Ser Cys Leu Leu  Thr Trp Asn 
    7295                 7300                 7305             


Pro Pro  Arg Asp Asp Gly Gly  Ser Lys Ile Thr Asn  Tyr Val Val 
    7310                 7315                 7320             


Glu Arg  Arg Ala Thr Asp Ser  Glu Val Trp His Lys  Leu Ser Ser 
    7325                 7330                 7335             


Thr Val  Lys Asp Thr Asn Phe  Lys Ala Thr Lys Leu  Ile Pro Asn 
    7340                 7345                 7350             


Lys Glu  Tyr Ile Phe Arg Val  Ala Ala Glu Asn Met  Tyr Gly Val 
    7355                 7360                 7365             


Gly Glu  Pro Val Gln Ala Ser  Pro Ile Thr Ala Lys  Tyr Gln Phe 
    7370                 7375                 7380             


Asp Pro  Pro Gly Pro Pro Thr  Arg Leu Glu Pro Ser  Asp Ile Thr 
    7385                 7390                 7395             


Lys Asp  Ala Val Thr Leu Thr  Trp Cys Glu Pro Asp  Asp Asp Gly 
    7400                 7405                 7410             


Gly Ser  Pro Ile Thr Gly Tyr  Trp Val Glu Arg Leu  Asp Pro Asp 
    7415                 7420                 7425             


Thr Asp  Lys Trp Val Arg Cys  Asn Lys Met Pro Val  Lys Asp Thr 
    7430                 7435                 7440             


Thr Tyr  Arg Val Lys Gly Leu  Thr Asn Lys Lys Lys  Tyr Arg Phe 
    7445                 7450                 7455             


Arg Val  Leu Ala Glu Asn Leu  Ala Gly Pro Gly Lys  Pro Ser Lys 
    7460                 7465                 7470             


Ser Thr  Glu Pro Ile Leu Ile  Lys Asp Pro Ile Asp  Pro Pro Trp 
    7475                 7480                 7485             


Pro Pro  Gly Lys Pro Thr Val  Lys Asp Val Gly Lys  Thr Ser Val 
    7490                 7495                 7500             


Arg Leu  Asn Trp Thr Lys Pro  Glu His Asp Gly Gly  Ala Lys Ile 
    7505                 7510                 7515             


Glu Ser  Tyr Val Ile Glu Met  Leu Lys Thr Gly Thr  Asp Glu Trp 
    7520                 7525                 7530             


Val Arg  Val Ala Glu Gly Val  Pro Thr Thr Gln His  Leu Leu Pro 
    7535                 7540                 7545             


Gly Leu  Met Glu Gly Gln Glu  Tyr Ser Phe Arg Val  Arg Ala Val 
    7550                 7555                 7560             


Asn Lys  Ala Gly Glu Ser Glu  Pro Ser Glu Pro Ser  Asp Pro Val 
    7565                 7570                 7575             


Leu Cys  Arg Glu Lys Leu Tyr  Pro Pro Ser Pro Pro  Arg Trp Leu 
    7580                 7585                 7590             


Glu Val  Ile Asn Ile Thr Lys  Asn Thr Ala Asp Leu  Lys Trp Thr 
    7595                 7600                 7605             


Val Pro  Glu Lys Asp Gly Gly  Ser Pro Ile Thr Asn  Tyr Ile Val 
    7610                 7615                 7620             


Glu Lys  Arg Asp Val Arg Arg  Lys Gly Trp Gln Thr  Val Asp Thr 
    7625                 7630                 7635             


Thr Val  Lys Asp Thr Lys Cys  Thr Val Thr Pro Leu  Thr Glu Gly 
    7640                 7645                 7650             


Ser Leu  Tyr Val Phe Arg Val  Ala Ala Glu Asn Ala  Ile Gly Gln 
    7655                 7660                 7665             


Ser Asp  Tyr Thr Glu Ile Glu  Asp Ser Val Leu Ala  Lys Asp Thr 
    7670                 7675                 7680             


Phe Thr  Thr Pro Gly Pro Pro  Tyr Ala Leu Ala Val  Val Asp Val 
    7685                 7690                 7695             


Thr Lys  Arg His Val Asp Leu  Lys Trp Glu Pro Pro  Lys Asn Asp 
    7700                 7705                 7710             


Gly Gly  Arg Pro Ile Gln Arg  Tyr Val Ile Glu Lys  Lys Glu Arg 
    7715                 7720                 7725             


Leu Gly  Thr Arg Trp Val Lys  Ala Gly Lys Thr Ala  Gly Pro Asp 
    7730                 7735                 7740             


Cys Asn  Phe Arg Val Thr Asp  Val Ile Glu Gly Thr  Glu Val Gln 
    7745                 7750                 7755             


Phe Gln  Val Arg Ala Glu Asn  Glu Ala Gly Val Gly  His Pro Ser 
    7760                 7765                 7770             


Glu Pro  Thr Glu Ile Leu Ser  Ile Glu Asp Pro Thr  Ser Pro Pro 
    7775                 7780                 7785             


Ser Pro  Pro Leu Asp Leu His  Val Thr Asp Ala Gly  Arg Lys His 
    7790                 7795                 7800             


Ile Ala  Ile Ala Trp Lys Pro  Pro Glu Lys Asn Gly  Gly Ser Pro 
    7805                 7810                 7815             


Ile Ile  Gly Tyr His Val Glu  Met Cys Pro Val Gly  Thr Glu Lys 
    7820                 7825                 7830             


Trp Met  Arg Val Asn Ser Arg  Pro Ile Lys Asp Leu  Lys Phe Lys 
    7835                 7840                 7845             


Val Glu  Glu Gly Val Val Pro  Asp Lys Glu Tyr Val  Leu Arg Val 
    7850                 7855                 7860             


Arg Ala  Val Asn Ala Ile Gly  Val Ser Glu Pro Ser  Glu Ile Ser 
    7865                 7870                 7875             


Glu Asn  Val Val Ala Lys Asp  Pro Asp Cys Lys Pro  Thr Ile Asp 
    7880                 7885                 7890             


Leu Glu  Thr His Asp Ile Ile  Val Ile Glu Gly Glu  Lys Leu Ser 
    7895                 7900                 7905             


Ile Pro  Val Pro Phe Arg Ala  Val Pro Val Pro Thr  Val Ser Trp 
    7910                 7915                 7920             


His Lys  Asp Gly Lys Glu Val  Lys Ala Ser Asp Arg  Leu Thr Met 
    7925                 7930                 7935             


Lys Asn  Asp His Ile Ser Ala  His Leu Glu Val Pro  Lys Ser Val 
    7940                 7945                 7950             


Arg Ala  Asp Ala Gly Ile Tyr  Thr Ile Thr Leu Glu  Asn Lys Leu 
    7955                 7960                 7965             


Gly Ser  Ala Thr Ala Ser Ile  Asn Val Lys Val Ile  Gly Leu Pro 
    7970                 7975                 7980             


Gly Pro  Cys Lys Asp Ile Lys  Ala Ser Asp Ile Thr  Lys Ser Ser 
    7985                 7990                 7995             


Cys Lys  Leu Thr Trp Glu Pro  Pro Glu Phe Asp Gly  Gly Thr Pro 
    8000                 8005                 8010             


Ile Leu  His Tyr Val Leu Glu  Arg Arg Glu Ala Gly  Arg Arg Thr 
    8015                 8020                 8025             


Tyr Ile  Pro Val Met Ser Gly  Glu Asn Lys Leu Ser  Trp Thr Val 
    8030                 8035                 8040             


Lys Asp  Leu Ile Pro Asn Gly  Glu Tyr Phe Phe Arg  Val Lys Ala 
    8045                 8050                 8055             


Val Asn  Lys Val Gly Gly Gly  Glu Tyr Ile Glu Leu  Lys Asn Pro 
    8060                 8065                 8070             


Val Ile  Ala Gln Asp Pro Lys  Gln Pro Pro Asp Pro  Pro Val Asp 
    8075                 8080                 8085             


Val Glu  Val His Asn Pro Thr  Ala Glu Ala Met Thr  Ile Thr Trp 
    8090                 8095                 8100             


Lys Pro  Pro Leu Tyr Asp Gly  Gly Ser Lys Ile Met  Gly Tyr Ile 
    8105                 8110                 8115             


Ile Glu  Lys Ile Ala Lys Gly  Glu Glu Arg Trp Lys  Arg Cys Asn 
    8120                 8125                 8130             


Glu His  Leu Val Pro Ile Leu  Thr Tyr Thr Ala Lys  Gly Leu Glu 
    8135                 8140                 8145             


Glu Gly  Lys Glu Tyr Gln Phe  Arg Val Arg Ala Glu  Asn Ala Ala 
    8150                 8155                 8160             


Gly Ile  Ser Glu Pro Ser Arg  Ala Thr Pro Pro Thr  Lys Ala Val 
    8165                 8170                 8175             


Asp Pro  Ile Asp Ala Pro Lys  Val Ile Leu Arg Thr  Ser Leu Glu 
    8180                 8185                 8190             


Val Lys  Arg Gly Asp Glu Ile  Ala Leu Asp Ala Ser  Ile Ser Gly 
    8195                 8200                 8205             


Ser Pro  Tyr Pro Thr Ile Thr  Trp Ile Lys Asp Glu  Asn Val Ile 
    8210                 8215                 8220             


Val Pro  Glu Glu Ile Lys Lys  Arg Ala Ala Pro Leu  Val Arg Arg 
    8225                 8230                 8235             


Arg Lys  Gly Glu Val Gln Glu  Glu Glu Pro Phe Val  Leu Pro Leu 
    8240                 8245                 8250             


Thr Gln  Arg Leu Ser Ile Asp  Asn Ser Lys Lys Gly  Glu Ser Gln 
    8255                 8260                 8265             


Leu Arg  Val Arg Asp Ser Leu  Arg Pro Asp His Gly  Leu Tyr Met 
    8270                 8275                 8280             


Ile Lys  Val Glu Asn Asp His  Gly Ile Ala Lys Ala  Pro Cys Thr 
    8285                 8290                 8295             


Val Ser  Val Leu Asp Thr Pro  Gly Pro Pro Ile Asn  Phe Val Phe 
    8300                 8305                 8310             


Glu Asp  Ile Arg Lys Thr Ser  Val Leu Cys Lys Trp  Glu Pro Pro 
    8315                 8320                 8325             


Leu Asp  Asp Gly Gly Ser Glu  Ile Ile Asn Tyr Thr  Leu Glu Lys 
    8330                 8335                 8340             


Lys Asp  Lys Thr Lys Pro Asp  Ser Glu Trp Ile Val  Val Thr Ser 
    8345                 8350                 8355             


Thr Leu  Arg His Cys Lys Tyr  Ser Val Thr Lys Leu  Ile Glu Gly 
    8360                 8365                 8370             


Lys Glu  Tyr Leu Phe Arg Val  Arg Ala Glu Asn Arg  Phe Gly Pro 
    8375                 8380                 8385             


Gly Pro  Pro Cys Val Ser Lys  Pro Leu Val Ala Lys  Asp Pro Phe 
    8390                 8395                 8400             


Gly Pro  Pro Asp Ala Pro Asp  Lys Pro Ile Val Glu  Asp Val Thr 
    8405                 8410                 8415             


Ser Asn  Ser Met Leu Val Lys  Trp Asn Glu Pro Lys  Asp Asn Gly 
    8420                 8425                 8430             


Ser Pro  Ile Leu Gly Tyr Trp  Leu Glu Lys Arg Glu  Val Asn Ser 
    8435                 8440                 8445             


Thr His  Trp Ser Arg Val Asn  Lys Ser Leu Leu Asn  Ala Leu Lys 
    8450                 8455                 8460             


Ala Asn  Val Asp Gly Leu Leu  Glu Gly Leu Thr Tyr  Val Phe Arg 
    8465                 8470                 8475             


Val Cys  Ala Glu Asn Ala Ala  Gly Pro Gly Lys Phe  Ser Pro Pro 
    8480                 8485                 8490             


Ser Asp  Pro Lys Thr Ala His  Asp Pro Ile Ser Pro  Pro Gly Pro 
    8495                 8500                 8505             


Pro Ile  Pro Arg Val Thr Asp  Thr Ser Ser Thr Thr  Ile Glu Leu 
    8510                 8515                 8520             


Glu Trp  Glu Pro Pro Ala Phe  Asn Gly Gly Gly Glu  Ile Val Gly 
    8525                 8530                 8535             


Tyr Phe  Val Asp Lys Gln Leu  Val Gly Thr Asn Glu  Trp Ser Arg 
    8540                 8545                 8550             


Cys Thr  Glu Lys Met Ile Lys  Val Arg Gln Tyr Thr  Val Lys Glu 
    8555                 8560                 8565             


Ile Arg  Glu Gly Ala Asp Tyr  Lys Leu Arg Val Ser  Ala Val Asn 
    8570                 8575                 8580             


Ala Ala  Gly Glu Gly Pro Pro  Gly Glu Thr Gln Pro  Val Thr Val 
    8585                 8590                 8595             


Ala Glu  Pro Gln Glu Pro Pro  Ala Val Glu Leu Asp  Val Ser Val 
    8600                 8605                 8610             


Lys Gly  Gly Ile Gln Ile Met  Ala Gly Lys Thr Leu  Arg Ile Pro 
    8615                 8620                 8625             


Ala Val  Val Thr Gly Arg Pro  Val Pro Thr Lys Val  Trp Thr Lys 
    8630                 8635                 8640             


Glu Glu  Gly Glu Leu Asp Lys  Asp Arg Val Val Ile  Asp Asn Val 
    8645                 8650                 8655             


Gly Thr  Lys Ser Glu Leu Ile  Ile Lys Asp Ala Leu  Arg Lys Asp 
    8660                 8665                 8670             


His Gly  Arg Tyr Val Ile Thr  Ala Thr Asn Ser Cys  Gly Ser Lys 
    8675                 8680                 8685             


Phe Ala  Ala Ala Arg Val Glu  Val Phe Asp Val Pro  Gly Pro Val 
    8690                 8695                 8700             


Leu Asp  Leu Lys Pro Val Val  Thr Asn Arg Lys Met  Cys Leu Leu 
    8705                 8710                 8715             


Asn Trp  Ser Asp Pro Glu Asp  Asp Gly Gly Ser Glu  Ile Thr Gly 
    8720                 8725                 8730             


Phe Ile  Ile Glu Arg Lys Asp  Ala Lys Met His Thr  Trp Arg Gln 
    8735                 8740                 8745             


Pro Ile  Glu Thr Glu Arg Ser  Lys Cys Asp Ile Thr  Gly Leu Leu 
    8750                 8755                 8760             


Glu Gly  Gln Glu Tyr Lys Phe  Arg Val Ile Ala Lys  Asn Lys Phe 
    8765                 8770                 8775             


Gly Cys  Gly Pro Pro Val Glu  Ile Gly Pro Ile Leu  Ala Val Asp 
    8780                 8785                 8790             


Pro Leu  Gly Pro Pro Thr Ser  Pro Glu Arg Leu Thr  Tyr Thr Glu 
    8795                 8800                 8805             


Arg Thr  Lys Ser Thr Ile Thr  Leu Asp Trp Lys Glu  Pro Arg Ser 
    8810                 8815                 8820             


Asn Gly  Gly Ser Pro Ile Gln  Gly Tyr Ile Ile Glu  Lys Arg Arg 
    8825                 8830                 8835             


His Asp  Lys Pro Asp Phe Glu  Arg Val Asn Lys Arg  Leu Cys Pro 
    8840                 8845                 8850             


Thr Thr  Ser Phe Leu Val Glu  Asn Leu Asp Glu His  Gln Met Tyr 
    8855                 8860                 8865             


Glu Phe  Arg Val Lys Ala Val  Asn Glu Ile Gly Glu  Ser Glu Pro 
    8870                 8875                 8880             


Ser Leu  Pro Leu Asn Val Val  Ile Gln Asp Asp Glu  Val Pro Pro 
    8885                 8890                 8895             


Thr Ile  Lys Leu Arg Leu Ser  Val Arg Gly Asp Thr  Ile Lys Val 
    8900                 8905                 8910             


Lys Ala  Gly Glu Pro Val His  Ile Pro Ala Asp Val  Thr Gly Leu 
    8915                 8920                 8925             


Pro Met  Pro Lys Ile Glu Trp  Ser Lys Asn Glu Thr  Val Ile Glu 
    8930                 8935                 8940             


Lys Pro  Thr Asp Ala Leu Gln  Ile Thr Lys Glu Glu  Val Ser Arg 
    8945                 8950                 8955             


Ser Glu  Ala Lys Thr Glu Leu  Ser Ile Pro Lys Ala  Val Arg Glu 
    8960                 8965                 8970             


Asp Lys  Gly Thr Tyr Thr Val  Thr Ala Ser Asn Arg  Leu Gly Ser 
    8975                 8980                 8985             


Val Phe  Arg Asn Val His Val  Glu Val Tyr Asp Arg  Pro Ser Pro 
    8990                 8995                 9000             


Pro Arg  Asn Leu Ala Val Thr  Asp Ile Lys Ala Glu  Ser Cys Tyr 
    9005                 9010                 9015             


Leu Thr  Trp Asp Ala Pro Leu  Asp Asn Gly Gly Ser  Glu Ile Thr 
    9020                 9025                 9030             


His Tyr  Val Ile Asp Lys Arg  Asp Ala Ser Arg Lys  Lys Ala Glu 
    9035                 9040                 9045             


Trp Glu  Glu Val Thr Asn Thr  Ala Val Glu Lys Arg  Tyr Gly Ile 
    9050                 9055                 9060             


Trp Lys  Leu Ile Pro Asn Gly  Gln Tyr Glu Phe Arg  Val Arg Ala 
    9065                 9070                 9075             


Val Asn  Lys Tyr Gly Ile Ser  Asp Glu Cys Lys Ser  Asp Lys Val 
    9080                 9085                 9090             


Val Ile  Gln Asp Pro Tyr Arg  Leu Pro Gly Pro Pro  Gly Lys Pro 
    9095                 9100                 9105             


Lys Val  Leu Ala Arg Thr Lys  Gly Ser Met Leu Val  Ser Trp Thr 
    9110                 9115                 9120             


Pro Pro  Leu Asp Asn Gly Gly  Ser Pro Ile Thr Gly  Tyr Trp Leu 
    9125                 9130                 9135             


Glu Lys  Arg Glu Glu Gly Ser  Pro Tyr Trp Ser Arg  Val Ser Arg 
    9140                 9145                 9150             


Ala Pro  Ile Thr Lys Val Gly  Leu Lys Gly Val Glu  Phe Asn Val 
    9155                 9160                 9165             


Pro Arg  Leu Leu Glu Gly Val  Lys Tyr Gln Phe Arg  Ala Met Ala 
    9170                 9175                 9180             


Ile Asn  Ala Ala Gly Ile Gly  Pro Pro Ser Glu Pro  Ser Asp Pro 
    9185                 9190                 9195             


Glu Val  Ala Gly Asp Pro Ile  Phe Pro Pro Gly Pro  Pro Ser Cys 
    9200                 9205                 9210             


Pro Glu  Val Lys Asp Lys Thr  Lys Ser Ser Ile Ser  Leu Gly Trp 
    9215                 9220                 9225             


Lys Pro  Pro Ala Lys Asp Gly  Gly Ser Pro Ile Lys  Gly Tyr Ile 
    9230                 9235                 9240             


Val Glu  Met Gln Glu Glu Gly  Thr Thr Asp Trp Lys  Arg Val Asn 
    9245                 9250                 9255             


Glu Pro  Asp Lys Leu Ile Thr  Thr Cys Glu Cys Val  Val Pro Asn 
    9260                 9265                 9270             


Leu Lys  Glu Leu Arg Lys Tyr  Arg Phe Arg Val Lys  Ala Val Asn 
    9275                 9280                 9285             


Glu Ala  Gly Glu Ser Glu Pro  Ser Asp Thr Thr Gly  Glu Ile Pro 
    9290                 9295                 9300             


Ala Thr  Asp Ile Gln Glu Glu  Pro Glu Val Phe Ile  Asp Ile Gly 
    9305                 9310                 9315             


Ala Gln  Asp Cys Leu Val Cys  Lys Ala Gly Ser Gln  Ile Arg Ile 
    9320                 9325                 9330             


Pro Ala  Val Ile Lys Gly Arg  Pro Thr Pro Lys Ser  Ser Trp Glu 
    9335                 9340                 9345             


Phe Asp  Gly Lys Ala Lys Lys  Ala Met Lys Asp Gly  Val His Asp 
    9350                 9355                 9360             


Ile Pro  Glu Asp Ala Gln Leu  Glu Thr Ala Glu Asn  Ser Ser Val 
    9365                 9370                 9375             


Ile Ile  Ile Pro Glu Cys Lys  Arg Ser His Thr Gly  Lys Tyr Ser 
    9380                 9385                 9390             


Ile Thr  Ala Lys Asn Lys Ala  Gly Gln Lys Thr Ala  Asn Cys Arg 
    9395                 9400                 9405             


Val Lys  Val Met Asp Val Pro  Gly Pro Pro Lys Asp  Leu Lys Val 
    9410                 9415                 9420             


Ser Asp  Ile Thr Arg Gly Ser  Cys Arg Leu Ser Trp  Lys Met Pro 
    9425                 9430                 9435             


Asp Asp  Asp Gly Gly Asp Arg  Ile Lys Gly Tyr Val  Ile Glu Lys 
    9440                 9445                 9450             


Arg Thr  Ile Asp Gly Lys Ala  Trp Thr Lys Val Asn  Pro Asp Cys 
    9455                 9460                 9465             


Gly Ser  Thr Thr Phe Val Val  Pro Asp Leu Leu Ser  Glu Gln Gln 
    9470                 9475                 9480             


Tyr Phe  Phe Arg Val Arg Ala  Glu Asn Arg Phe Gly  Ile Gly Pro 
    9485                 9490                 9495             


Pro Val  Glu Thr Ile Gln Arg  Thr Thr Ala Arg Asp  Pro Ile Tyr 
    9500                 9505                 9510             


Pro Pro  Asp Pro Pro Ile Lys  Leu Lys Ile Gly Leu  Ile Thr Lys 
    9515                 9520                 9525             


Asn Thr  Val His Leu Ser Trp  Lys Pro Pro Lys Asn  Asp Gly Gly 
    9530                 9535                 9540             


Ser Pro  Val Thr His Tyr Ile  Val Glu Cys Leu Ala  Trp Asp Pro 
    9545                 9550                 9555             


Thr Gly  Thr Lys Lys Glu Ala  Trp Arg Gln Cys Asn  Lys Arg Asp 
    9560                 9565                 9570             


Val Glu  Glu Leu Gln Phe Thr  Val Glu Asp Leu Val  Glu Gly Gly 
    9575                 9580                 9585             


Glu Tyr  Glu Phe Arg Val Lys  Ala Val Asn Ala Ala  Gly Val Ser 
    9590                 9595                 9600             


Lys Pro  Ser Ala Thr Val Gly  Pro Cys Asp Cys Gln  Arg Pro Asp 
    9605                 9610                 9615             


Met Pro  Pro Ser Ile Asp Leu  Lys Glu Phe Met Glu  Val Glu Glu 
    9620                 9625                 9630             


Gly Thr  Asn Val Asn Ile Val  Ala Lys Ile Lys Gly  Val Pro Phe 
    9635                 9640                 9645             


Pro Thr  Leu Thr Trp Phe Lys  Ala Pro Pro Lys Lys  Pro Asp Asn 
    9650                 9655                 9660             


Lys Glu  Pro Val Leu Tyr Asp  Thr His Val Asn Lys  Leu Val Val 
    9665                 9670                 9675             


Asp Asp  Thr Cys Thr Leu Val  Ile Pro Gln Ser Arg  Arg Ser Asp 
    9680                 9685                 9690             


Thr Gly  Leu Tyr Thr Ile Thr  Ala Val Asn Asn Leu  Gly Thr Ala 
    9695                 9700                 9705             


Ser Lys  Glu Met Arg Leu Asn  Val Leu Gly Arg Pro  Gly Pro Pro 
    9710                 9715                 9720             


Val Gly  Pro Ile Lys Phe Glu  Ser Val Ser Ala Asp  Gln Met Thr 
    9725                 9730                 9735             


Leu Ser  Trp Phe Pro Pro Lys  Asp Asp Gly Gly Ser  Lys Ile Thr 
    9740                 9745                 9750             


Asn Tyr  Val Ile Glu Lys Arg  Glu Ala Asn Arg Lys  Thr Trp Val 
    9755                 9760                 9765             


His Val  Ser Ser Glu Pro Lys  Glu Cys Thr Tyr Thr  Ile Pro Lys 
    9770                 9775                 9780             


Leu Leu  Glu Gly His Glu Tyr  Val Phe Arg Ile Met  Ala Gln Asn 
    9785                 9790                 9795             


Lys Tyr  Gly Ile Gly Glu Pro  Leu Asp Ser Glu Pro  Glu Thr Ala 
    9800                 9805                 9810             


Arg Asn  Leu Phe Ser Val Pro  Gly Ala Pro Asp Lys  Pro Thr Val 
    9815                 9820                 9825             


Ser Ser  Val Thr Arg Asn Ser  Met Thr Val Asn Trp  Glu Glu Pro 
    9830                 9835                 9840             


Glu Tyr  Asp Gly Gly Ser Pro  Val Thr Gly Tyr Trp  Leu Glu Met 
    9845                 9850                 9855             


Lys Asp  Thr Thr Ser Lys Arg  Trp Lys Arg Val Asn  Arg Asp Pro 
    9860                 9865                 9870             


Ile Lys  Ala Met Thr Leu Gly  Val Ser Tyr Lys Val  Thr Gly Leu 
    9875                 9880                 9885             


Ile Glu  Gly Ser Asp Tyr Gln  Phe Arg Val Tyr Ala  Ile Asn Ala 
    9890                 9895                 9900             


Ala Gly  Val Gly Pro Ala Ser  Leu Pro Ser Asp Pro  Ala Thr Ala 
    9905                 9910                 9915             


Arg Asp  Pro Ile Ala Pro Pro  Gly Pro Pro Phe Pro  Lys Val Thr 
    9920                 9925                 9930             


Asp Trp  Thr Lys Ser Ser Ala  Asp Leu Glu Trp Ser  Pro Pro Leu 
    9935                 9940                 9945             


Lys Asp  Gly Gly Ser Lys Val  Thr Gly Tyr Ile Val  Glu Tyr Lys 
    9950                 9955                 9960             


Glu Glu  Gly Lys Glu Glu Trp  Glu Lys Gly Lys Asp  Lys Glu Val 
    9965                 9970                 9975             


Arg Gly  Thr Lys Leu Val Val  Thr Gly Leu Lys Glu  Gly Ala Phe 
    9980                 9985                 9990             


Tyr Lys  Phe Arg Val Ser Ala   Val Asn Ile Ala Gly   Ile Gly Glu 
    9995                 10000                 10005             


Pro Gly   Glu Val Thr Asp Val   Ile Glu Met Lys Asp   Arg Leu Val 
    10010                 10015                 10020             


Ser Pro   Asp Leu Gln Leu Asp   Ala Ser Val Arg Asp   Arg Ile Val 
    10025                 10030                 10035             


Val His   Ala Gly Gly Val Ile   Arg Ile Ile Ala Tyr   Val Ser Gly 
    10040                 10045                 10050             


Lys Pro   Pro Pro Thr Val Thr   Trp Asn Met Asn Glu   Arg Thr Leu 
    10055                 10060                 10065             


Pro Gln   Glu Ala Thr Ile Glu   Thr Thr Ala Ile Ser   Ser Ser Met 
    10070                 10075                 10080             


Val Ile   Lys Asn Cys Gln Arg   Ser His Gln Gly Val   Tyr Ser Leu 
    10085                 10090                 10095             


Leu Ala   Lys Asn Glu Ala Gly   Glu Arg Lys Lys Thr   Ile Ile Val 
    10100                 10105                 10110             


Asp Val   Leu Asp Val Pro Gly   Pro Val Gly Thr Pro   Phe Leu Ala 
    10115                 10120                 10125             


His Asn   Leu Thr Asn Glu Ser   Cys Lys Leu Thr Trp   Phe Ser Pro 
    10130                 10135                 10140             


Glu Asp   Asp Gly Gly Ser Pro   Ile Thr Asn Tyr Val   Ile Glu Lys 
    10145                 10150                 10155             


Arg Glu   Ser Asp Arg Arg Ala   Trp Thr Pro Val Thr   Tyr Thr Val 
    10160                 10165                 10170             


Thr Arg   Gln Asn Ala Thr Val   Gln Gly Leu Ile Gln   Gly Lys Ala 
    10175                 10180                 10185             


Tyr Phe   Phe Arg Ile Ala Ala   Glu Asn Ser Ile Gly   Met Gly Pro 
    10190                 10195                 10200             


Phe Val   Glu Thr Ser Glu Ala   Leu Val Ile Arg Glu   Pro Ile Thr 
    10205                 10210                 10215             


Val Pro   Glu Arg Pro Glu Asp   Leu Glu Val Lys Glu   Val Thr Lys 
    10220                 10225                 10230             


Asn Thr   Val Thr Leu Thr Trp   Asn Pro Pro Lys Tyr   Asp Gly Gly 
    10235                 10240                 10245             


Ser Glu   Ile Ile Asn Tyr Val   Leu Glu Ser Arg Leu   Ile Gly Thr 
    10250                 10255                 10260             


Glu Lys   Phe His Lys Val Thr   Asn Asp Asn Leu Leu   Ser Arg Lys 
    10265                 10270                 10275             


Tyr Thr   Val Lys Gly Leu Lys   Glu Gly Asp Thr Tyr   Glu Tyr Arg 
    10280                 10285                 10290             


Val Ser   Ala Val Asn Ile Val   Gly Gln Gly Lys Pro   Ser Phe Cys 
    10295                 10300                 10305             


Thr Lys   Pro Ile Thr Cys Lys   Asp Glu Leu Ala Pro   Pro Thr Leu 
    10310                 10315                 10320             


His Leu   Asp Phe Arg Asp Lys   Leu Thr Ile Arg Val   Gly Glu Ala 
    10325                 10330                 10335             


Phe Ala   Leu Thr Gly Arg Tyr   Ser Gly Lys Pro Lys   Pro Lys Val 
    10340                 10345                 10350             


Ser Trp   Phe Lys Asp Glu Ala   Asp Val Leu Glu Asp   Asp Arg Thr 
    10355                 10360                 10365             


His Ile   Lys Thr Thr Pro Ala   Thr Leu Ala Leu Glu   Lys Ile Lys 
    10370                 10375                 10380             


Ala Lys   Arg Ser Asp Ser Gly   Lys Tyr Cys Val Val   Val Glu Asn 
    10385                 10390                 10395             


Ser Thr   Gly Ser Arg Lys Gly   Phe Cys Gln Val Asn   Val Val Asp 
    10400                 10405                 10410             


Arg Pro   Gly Pro Pro Val Gly   Pro Val Ser Phe Asp   Glu Val Thr 
    10415                 10420                 10425             


Lys Asp   Tyr Met Val Ile Ser   Trp Lys Pro Pro Leu   Asp Asp Gly 
    10430                 10435                 10440             


Gly Ser   Lys Ile Thr Asn Tyr   Ile Ile Glu Lys Lys   Glu Val Gly 
    10445                 10450                 10455             


Lys Asp   Val Trp Met Pro Val   Thr Ser Ala Ser Ala   Lys Thr Thr 
    10460                 10465                 10470             


Cys Lys   Val Ser Lys Leu Leu   Glu Gly Lys Asp Tyr   Ile Phe Arg 
    10475                 10480                 10485             


Ile His   Ala Glu Asn Leu Tyr   Gly Ile Ser Asp Pro   Leu Val Ser 
    10490                 10495                 10500             


Asp Ser   Met Lys Ala Lys Asp   Arg Phe Arg Val Pro   Asp Ala Pro 
    10505                 10510                 10515             


Asp Gln   Pro Ile Val Thr Glu   Val Thr Lys Asp Ser   Ala Leu Val 
    10520                 10525                 10530             


Thr Trp   Asn Lys Pro His Asp   Gly Gly Lys Pro Ile   Thr Asn Tyr 
    10535                 10540                 10545             


Ile Leu   Glu Lys Arg Glu Thr   Met Ser Lys Arg Trp   Ala Arg Val 
    10550                 10555                 10560             


Thr Lys   Asp Pro Ile His Pro   Tyr Thr Lys Phe Arg   Val Pro Asp 
    10565                 10570                 10575             


Leu Leu   Glu Gly Cys Gln Tyr   Glu Phe Arg Val Ser   Ala Glu Asn 
    10580                 10585                 10590             


Glu Ile   Gly Ile Gly Asp Pro   Ser Pro Pro Ser Lys   Pro Val Phe 
    10595                 10600                 10605             


Ala Lys   Asp Pro Ile Ala Lys   Pro Ser Pro Pro Val   Asn Pro Glu 
    10610                 10615                 10620             


Ala Ile   Asp Thr Thr Cys Asn   Ser Val Asp Leu Thr   Trp Gln Pro 
    10625                 10630                 10635             


Pro Arg   His Asp Gly Gly Ser   Lys Ile Leu Gly Tyr   Ile Val Glu 
    10640                 10645                 10650             


Tyr Gln   Lys Val Gly Asp Glu   Glu Trp Arg Arg Ala   Asn His Thr 
    10655                 10660                 10665             


Pro Glu   Ser Cys Pro Glu Thr   Lys Tyr Lys Val Thr   Gly Leu Arg 
    10670                 10675                 10680             


Asp Gly   Gln Thr Tyr Lys Phe   Arg Val Leu Ala Val   Asn Ala Ala 
    10685                 10690                 10695             


Gly Glu   Ser Asp Pro Ala His   Val Pro Glu Pro Val   Leu Val Lys 
    10700                 10705                 10710             


Asp Arg   Leu Glu Pro Pro Glu   Leu Ile Leu Asp Ala   Asn Met Ala 
    10715                 10720                 10725             


Arg Glu   Gln His Ile Lys Val   Gly Asp Thr Leu Arg   Leu Ser Ala 
    10730                 10735                 10740             


Ile Ile   Lys Gly Val Pro Phe   Pro Lys Val Thr Trp   Lys Lys Glu 
    10745                 10750                 10755             


Asp Arg   Asp Ala Pro Thr Lys   Ala Arg Ile Asp Val   Thr Pro Val 
    10760                 10765                 10770             


Gly Ser   Lys Leu Glu Ile Arg   Asn Ala Ala His Glu   Asp Gly Gly 
    10775                 10780                 10785             


Ile Tyr   Ser Leu Thr Val Glu   Asn Pro Ala Gly Ser   Lys Thr Val 
    10790                 10795                 10800             


Ser Val   Lys Val Leu Val Leu   Asp Lys Pro Gly Pro   Pro Arg Asp 
    10805                 10810                 10815             


Leu Glu   Val Ser Glu Ile Arg   Lys Asp Ser Cys Tyr   Leu Thr Trp 
    10820                 10825                 10830             


Lys Glu   Pro Leu Asp Asp Gly   Gly Ser Val Ile Thr   Asn Tyr Val 
    10835                 10840                 10845             


Val Glu   Arg Arg Asp Val Ala   Ser Ala Gln Trp Ser   Pro Leu Ser 
    10850                 10855                 10860             


Ala Thr   Ser Lys Lys Lys Ser   His Phe Ala Lys His   Leu Asn Glu 
    10865                 10870                 10875             


Gly Asn   Gln Tyr Leu Phe Arg   Val Ala Ala Glu Asn   Gln Tyr Gly 
    10880                 10885                 10890             


Arg Gly   Pro Phe Val Glu Thr   Pro Lys Pro Ile Lys   Ala Leu Asp 
    10895                 10900                 10905             


Pro Leu   His Pro Pro Gly Pro   Pro Lys Asp Leu His   His Val Asp 
    10910                 10915                 10920             


Val Asp   Lys Thr Glu Val Ser   Leu Val Trp Asn Lys   Pro Asp Arg 
    10925                 10930                 10935             


Asp Gly   Gly Ser Pro Ile Thr   Gly Tyr Leu Val Glu   Tyr Gln Glu 
    10940                 10945                 10950             


Glu Gly   Thr Gln Asp Trp Ile   Lys Phe Lys Thr Val   Thr Asn Leu 
    10955                 10960                 10965             


Glu Cys   Val Val Thr Gly Leu   Gln Gln Gly Lys Thr   Tyr Arg Phe 
    10970                 10975                 10980             


Arg Val   Lys Ala Glu Asn Ile   Val Gly Leu Gly Leu   Pro Asp Thr 
    10985                 10990                 10995             


Thr Ile   Pro Ile Glu Cys Gln   Glu Lys Leu Val Pro   Pro Ser Val 
    11000                 11005                 11010             


Glu Leu   Asp Val Lys Leu Ile   Glu Gly Leu Val Val   Lys Ala Gly 
    11015                 11020                 11025             


Thr Thr   Val Arg Phe Pro Ala   Ile Ile Arg Gly Val   Pro Val Pro 
    11030                 11035                 11040             


Thr Ala   Lys Trp Thr Thr Asp   Gly Ser Glu Ile Lys   Thr Asp Glu 
    11045                 11050                 11055             


His Tyr   Thr Val Glu Thr Asp   Asn Phe Ser Ser Val   Leu Thr Ile 
    11060                 11065                 11070             


Lys Asn   Cys Leu Arg Arg Asp   Thr Gly Glu Tyr Gln   Ile Thr Val 
    11075                 11080                 11085             


Ser Asn   Ala Ala Gly Ser Lys   Thr Val Ala Val His   Leu Thr Val 
    11090                 11095                 11100             


Leu Asp   Val Pro Gly Pro Pro   Thr Gly Pro Ile Asn   Ile Leu Asp 
    11105                 11110                 11115             


Val Thr   Pro Glu His Met Thr   Ile Ser Trp Gln Pro   Pro Lys Asp 
    11120                 11125                 11130             


Asp Gly   Gly Ser Pro Val Ile   Asn Tyr Ile Val Glu   Lys Gln Asp 
    11135                 11140                 11145             


Thr Arg   Lys Asp Thr Trp Gly   Val Val Ser Ser Gly   Ser Ser Lys 
    11150                 11155                 11160             


Thr Lys   Leu Lys Ile Pro His   Leu Gln Lys Gly Cys   Glu Tyr Val 
    11165                 11170                 11175             


Phe Arg   Val Arg Ala Glu Asn   Lys Ile Gly Val Gly   Pro Pro Leu 
    11180                 11185                 11190             


Asp Ser   Thr Pro Thr Val Ala   Lys His Lys Phe Ser   Pro Pro Ser 
    11195                 11200                 11205             


Pro Pro   Gly Lys Pro Val Val   Thr Asp Ile Thr Glu   Asn Ala Ala 
    11210                 11215                 11220             


Thr Val   Ser Trp Thr Leu Pro   Lys Ser Asp Gly Gly   Ser Pro Ile 
    11225                 11230                 11235             


Thr Gly   Tyr Tyr Met Glu Arg   Arg Glu Val Thr Gly   Lys Trp Val 
    11240                 11245                 11250             


Arg Val   Asn Lys Thr Pro Ile   Ala Asp Leu Lys Phe   Arg Val Thr 
    11255                 11260                 11265             


Gly Leu   Tyr Glu Gly Asn Thr   Tyr Glu Phe Arg Val   Phe Ala Glu 
    11270                 11275                 11280             


Asn Leu   Ala Gly Leu Ser Lys   Pro Ser Pro Ser Ser   Asp Pro Ile 
    11285                 11290                 11295             


Lys Ala   Cys Arg Pro Ile Lys   Pro Pro Gly Pro Pro   Ile Asn Pro 
    11300                 11305                 11310             


Lys Leu   Lys Asp Lys Ser Arg   Glu Thr Ala Asp Leu   Val Trp Thr 
    11315                 11320                 11325             


Lys Pro   Leu Ser Asp Gly Gly   Ser Pro Ile Leu Gly   Tyr Val Val 
    11330                 11335                 11340             


Glu Cys   Gln Lys Pro Gly Thr   Ala Gln Trp Asn Arg   Ile Asn Lys 
    11345                 11350                 11355             


Asp Glu   Leu Ile Arg Gln Cys   Ala Phe Arg Val Pro   Gly Leu Ile 
    11360                 11365                 11370             


Glu Gly   Asn Glu Tyr Arg Phe   Arg Ile Lys Ala Ala   Asn Ile Val 
    11375                 11380                 11385             


Gly Glu   Gly Glu Pro Arg Glu   Leu Ala Glu Ser Val   Ile Ala Lys 
    11390                 11395                 11400             


Asp Ile   Leu His Pro Pro Glu   Val Glu Leu Asp Val   Thr Cys Arg 
    11405                 11410                 11415             


Asp Val   Ile Thr Val Arg Val   Gly Gln Thr Ile Arg   Ile Leu Ala 
    11420                 11425                 11430             


Arg Val   Lys Gly Arg Pro Glu   Pro Asp Ile Thr Trp   Thr Lys Glu 
    11435                 11440                 11445             


Gly Lys   Val Leu Val Arg Glu   Lys Arg Val Asp Leu   Ile Gln Asp 
    11450                 11455                 11460             


Leu Pro   Arg Val Glu Leu Gln   Ile Lys Glu Ala Val   Arg Ala Asp 
    11465                 11470                 11475             


His Gly   Lys Tyr Ile Ile Ser   Ala Lys Asn Ser Ser   Gly His Ala 
    11480                 11485                 11490             


Gln Gly   Ser Ala Ile Val Asn   Val Leu Asp Arg Pro   Gly Pro Cys 
    11495                 11500                 11505             


Gln Asn   Leu Lys Val Thr Asn   Val Thr Lys Glu Asn   Cys Thr Ile 
    11510                 11515                 11520             


Ser Trp   Glu Asn Pro Leu Asp   Asn Gly Gly Ser Glu   Ile Thr Asn 
    11525                 11530                 11535             


Phe Ile   Val Glu Tyr Arg Lys   Pro Asn Gln Lys Gly   Trp Ser Ile 
    11540                 11545                 11550             


Val Ala   Ser Asp Val Thr Lys   Arg Leu Ile Lys Ala   Asn Leu Leu 
    11555                 11560                 11565             


Ala Asn   Asn Glu Tyr Tyr Phe   Arg Val Cys Ala Glu   Asn Lys Val 
    11570                 11575                 11580             


Gly Val   Gly Pro Thr Ile Glu   Thr Lys Thr Pro Ile   Leu Ala Ile 
    11585                 11590                 11595             


Asn Pro   Ile Asp Arg Pro Gly   Glu Pro Glu Asn Leu   His Ile Ala 
    11600                 11605                 11610             


Asp Lys   Gly Lys Thr Phe Val   Tyr Leu Lys Trp Arg   Arg Pro Asp 
    11615                 11620                 11625             


Tyr Asp   Gly Gly Ser Pro Asn   Leu Ser Tyr His Val   Glu Arg Arg 
    11630                 11635                 11640             


Leu Lys   Gly Ser Asp Asp Trp   Glu Arg Val His Lys   Gly Ser Ile 
    11645                 11650                 11655             


Lys Glu   Thr His Tyr Met Val   Asp Arg Cys Val Glu   Asn Gln Ile 
    11660                 11665                 11670             


Tyr Glu   Phe Arg Val Gln Thr   Lys Asn Glu Gly Gly   Glu Ser Asp 
    11675                 11680                 11685             


Trp Val   Lys Thr Glu Glu Val   Val Val Lys Glu Asp   Leu Gln Lys 
    11690                 11695                 11700             


Pro Val   Leu Asp Leu Lys Leu   Ser Gly Val Leu Thr   Val Lys Ala 
    11705                 11710                 11715             


Gly Asp   Thr Ile Arg Leu Glu   Ala Gly Val Arg Gly   Lys Pro Phe 
    11720                 11725                 11730             


Pro Glu   Val Ala Trp Thr Lys   Asp Lys Asp Ala Thr   Asp Leu Thr 
    11735                 11740                 11745             


Arg Ser   Pro Arg Val Lys Ile   Asp Thr Arg Ala Asp   Ser Ser Lys 
    11750                 11755                 11760             


Phe Ser   Leu Thr Lys Ala Lys   Arg Ser Asp Gly Gly   Lys Tyr Val 
    11765                 11770                 11775             


Val Thr   Ala Thr Asn Thr Ala   Gly Ser Phe Val Ala   Tyr Ala Thr 
    11780                 11785                 11790             


Val Asn   Val Leu Asp Lys Pro   Gly Pro Val Arg Asn   Leu Lys Ile 
    11795                 11800                 11805             


Val Asp   Val Ser Ser Asp Arg   Cys Thr Val Cys Trp   Asp Pro Pro 
    11810                 11815                 11820             


Glu Asp   Asp Gly Gly Cys Glu   Ile Gln Asn Tyr Ile   Leu Glu Lys 
    11825                 11830                 11835             


Cys Glu   Thr Lys Arg Met Val   Trp Ser Thr Tyr Ser   Ala Thr Val 
    11840                 11845                 11850             


Leu Thr   Pro Gly Thr Thr Val   Thr Arg Leu Ile Glu   Gly Asn Glu 
    11855                 11860                 11865             


Tyr Ile   Phe Arg Val Arg Ala   Glu Asn Lys Ile Gly   Thr Gly Pro 
    11870                 11875                 11880             


Pro Thr   Glu Ser Lys Pro Val   Ile Ala Lys Thr Lys   Tyr Asp Lys 
    11885                 11890                 11895             


Pro Gly   Arg Pro Asp Pro Pro   Glu Val Thr Lys Val   Ser Lys Glu 
    11900                 11905                 11910             


Glu Met   Thr Val Val Trp Asn   Pro Pro Glu Tyr Asp   Gly Gly Lys 
    11915                 11920                 11925             


Ser Ile   Thr Gly Tyr Phe Leu   Glu Lys Lys Glu Lys   His Ser Thr 
    11930                 11935                 11940             


Arg Trp   Val Pro Val Asn Lys   Ser Ala Ile Pro Glu   Arg Arg Met 
    11945                 11950                 11955             


Lys Val   Gln Asn Leu Leu Pro   Asp His Glu Tyr Gln   Phe Arg Val 
    11960                 11965                 11970             


Lys Ala   Glu Asn Glu Ile Gly   Ile Gly Glu Pro Ser   Leu Pro Ser 
    11975                 11980                 11985             


Arg Pro   Val Val Ala Lys Asp   Pro Ile Glu Pro Pro   Gly Pro Pro 
    11990                 11995                 12000             


Thr Asn   Phe Arg Val Val Asp   Thr Thr Lys His Ser   Ile Thr Leu 
    12005                 12010                 12015             


Gly Trp   Gly Lys Pro Val Tyr   Asp Gly Gly Ala Pro   Ile Ile Gly 
    12020                 12025                 12030             


Tyr Val   Val Glu Met Arg Pro   Lys Ile Ala Asp Ala   Ser Pro Asp 
    12035                 12040                 12045             


Glu Gly   Trp Lys Arg Cys Asn   Ala Ala Ala Gln Leu   Val Arg Lys 
    12050                 12055                 12060             


Glu Phe   Thr Val Thr Ser Leu   Asp Glu Asn Gln Glu   Tyr Glu Phe 
    12065                 12070                 12075             


Arg Val   Cys Ala Gln Asn Gln   Val Gly Ile Gly Arg   Pro Ala Glu 
    12080                 12085                 12090             


Leu Lys   Glu Ala Ile Lys Pro   Lys Glu Ile Leu Glu   Pro Pro Glu 
    12095                 12100                 12105             


Ile Asp   Leu Asp Ala Ser Met   Arg Lys Leu Val Ile   Val Arg Ala 
    12110                 12115                 12120             


Gly Cys   Pro Ile Arg Leu Phe   Ala Ile Val Arg Gly   Arg Pro Ala 
    12125                 12130                 12135             


Pro Lys   Val Thr Trp Arg Lys   Val Gly Ile Asp Asn   Val Val Arg 
    12140                 12145                 12150             


Lys Gly   Gln Val Asp Leu Val   Asp Thr Met Ala Phe   Leu Val Ile 
    12155                 12160                 12165             


Pro Asn   Ser Thr Arg Asp Asp   Ser Gly Lys Tyr Ser   Leu Thr Leu 
    12170                 12175                 12180             


Val Asn   Pro Ala Gly Glu Lys   Ala Val Phe Val Asn   Val Arg Val 
    12185                 12190                 12195             


Leu Asp   Thr Pro Gly Pro Val   Ser Asp Leu Lys Val   Ser Asp Val 
    12200                 12205                 12210             


Thr Lys   Thr Ser Cys His Val   Ser Trp Ala Pro Pro   Glu Asn Asp 
    12215                 12220                 12225             


Gly Gly   Ser Gln Val Thr His   Tyr Ile Val Glu Lys   Arg Glu Ala 
    12230                 12235                 12240             


Asp Arg   Lys Thr Trp Ser Thr   Val Thr Pro Glu Val   Lys Lys Thr 
    12245                 12250                 12255             


Ser Phe   His Val Thr Asn Leu   Val Pro Gly Asn Glu   Tyr Tyr Phe 
    12260                 12265                 12270             


Arg Val   Thr Ala Val Asn Glu   Tyr Gly Pro Gly Val   Pro Thr Asp 
    12275                 12280                 12285             


Val Pro   Lys Pro Val Leu Ala   Ser Asp Pro Leu Ser   Glu Pro Asp 
    12290                 12295                 12300             


Pro Pro   Arg Lys Leu Glu Val   Thr Glu Met Thr Lys   Asn Ser Ala 
    12305                 12310                 12315             


Thr Leu   Ala Trp Leu Pro Pro   Leu Arg Asp Gly Gly   Ala Lys Ile 
    12320                 12325                 12330             


Asp Gly   Tyr Ile Thr Ser Tyr   Arg Glu Glu Glu Gln   Pro Ala Asp 
    12335                 12340                 12345             


Arg Trp   Thr Glu Tyr Ser Val   Val Lys Asp Leu Ser   Leu Val Val 
    12350                 12355                 12360             


Thr Gly   Leu Lys Glu Gly Lys   Lys Tyr Lys Phe Arg   Val Ala Ala 
    12365                 12370                 12375             


Arg Asn   Ala Val Gly Val Ser   Leu Pro Arg Glu Ala   Glu Gly Val 
    12380                 12385                 12390             


Tyr Glu   Ala Lys Glu Gln Leu   Leu Pro Pro Lys Ile   Leu Met Pro 
    12395                 12400                 12405             


Glu Gln   Ile Thr Ile Lys Ala   Gly Lys Lys Leu Arg   Ile Glu Ala 
    12410                 12415                 12420             


His Val   Tyr Gly Lys Pro His   Pro Thr Cys Lys Trp   Lys Lys Gly 
    12425                 12430                 12435             


Glu Asp   Glu Val Val Thr Ser   Ser His Leu Ala Val   His Lys Ala 
    12440                 12445                 12450             


Asp Ser   Ser Ser Ile Leu Ile   Ile Lys Asp Val Thr   Arg Lys Asp 
    12455                 12460                 12465             


Ser Gly   Tyr Tyr Ser Leu Thr   Ala Glu Asn Ser Ser   Gly Thr Asp 
    12470                 12475                 12480             


Thr Gln   Lys Ile Lys Val Val   Val Met Asp Ala Pro   Gly Pro Pro 
    12485                 12490                 12495             


Gln Pro   Pro Phe Asp Ile Ser   Asp Ile Asp Ala Asp   Ala Cys Ser 
    12500                 12505                 12510             


Leu Ser   Trp His Ile Pro Leu   Glu Asp Gly Gly Ser   Asn Ile Thr 
    12515                 12520                 12525             


Asn Tyr   Ile Val Glu Lys Cys   Asp Val Ser Arg Gly   Asp Trp Val 
    12530                 12535                 12540             


Thr Ala   Leu Ala Ser Val Thr   Lys Thr Ser Cys Arg   Val Gly Lys 
    12545                 12550                 12555             


Leu Ile   Pro Gly Gln Glu Tyr   Ile Phe Arg Val Arg   Ala Glu Asn 
    12560                 12565                 12570             


Arg Phe   Gly Ile Ser Glu Pro   Leu Thr Ser Pro Lys   Met Val Ala 
    12575                 12580                 12585             


Gln Phe   Pro Phe Gly Val Pro   Ser Glu Pro Lys Asn   Ala Arg Val 
    12590                 12595                 12600             


Thr Lys   Val Asn Lys Asp Cys   Ile Phe Val Ala Trp   Asp Arg Pro 
    12605                 12610                 12615             


Asp Ser   Asp Gly Gly Ser Pro   Ile Ile Gly Tyr Leu   Ile Glu Arg 
    12620                 12625                 12630             


Lys Glu   Arg Asn Ser Leu Leu   Trp Val Lys Ala Asn   Asp Thr Leu 
    12635                 12640                 12645             


Val Arg   Ser Thr Glu Tyr Pro   Cys Ala Gly Leu Val   Glu Gly Leu 
    12650                 12655                 12660             


Glu Tyr   Ser Phe Arg Ile Tyr   Ala Leu Asn Lys Ala   Gly Ser Ser 
    12665                 12670                 12675             


Pro Pro   Ser Lys Pro Thr Glu   Tyr Val Thr Ala Arg   Met Pro Val 
    12680                 12685                 12690             


Asp Pro   Pro Gly Lys Pro Glu   Val Ile Asp Val Thr   Lys Ser Thr 
    12695                 12700                 12705             


Val Ser   Leu Ile Trp Ala Arg   Pro Lys His Asp Gly   Gly Ser Lys 
    12710                 12715                 12720             


Ile Ile   Gly Tyr Phe Val Glu   Ala Cys Lys Leu Pro   Gly Asp Lys 
    12725                 12730                 12735             


Trp Val   Arg Cys Asn Thr Ala   Pro His Gln Ile Pro   Gln Glu Glu 
    12740                 12745                 12750             


Tyr Thr   Ala Thr Gly Leu Glu   Glu Lys Ala Gln Tyr   Gln Phe Arg 
    12755                 12760                 12765             


Ala Ile   Ala Arg Thr Ala Val   Asn Ile Ser Pro Pro   Ser Glu Pro 
    12770                 12775                 12780             


Ser Asp   Pro Val Thr Ile Leu   Ala Glu Asn Val Pro   Pro Arg Ile 
    12785                 12790                 12795             


Asp Leu   Ser Val Ala Met Lys   Ser Leu Leu Thr Val   Lys Ala Gly 
    12800                 12805                 12810             


Thr Asn   Val Cys Leu Asp Ala   Thr Val Phe Gly Lys   Pro Met Pro 
    12815                 12820                 12825             


Thr Val   Ser Trp Lys Lys Asp   Gly Thr Leu Leu Lys   Pro Ala Glu 
    12830                 12835                 12840             


Gly Ile   Lys Met Ala Met Gln   Arg Asn Leu Cys Thr   Leu Glu Leu 
    12845                 12850                 12855             


Phe Ser   Val Asn Arg Lys Asp   Ser Gly Asp Tyr Thr   Ile Thr Ala 
    12860                 12865                 12870             


Glu Asn   Ser Ser Gly Ser Lys   Ser Ala Thr Ile Lys   Leu Lys Val 
    12875                 12880                 12885             


Leu Asp   Lys Pro Gly Pro Pro   Ala Ser Val Lys Ile   Asn Lys Met 
    12890                 12895                 12900             


Tyr Ser   Asp Arg Ala Met Leu   Ser Trp Glu Pro Pro   Leu Glu Asp 
    12905                 12910                 12915             


Gly Gly   Ser Glu Ile Thr Asn   Tyr Ile Val Asp Lys   Arg Glu Thr 
    12920                 12925                 12930             


Ser Arg   Pro Asn Trp Ala Gln   Val Ser Ala Thr Val   Pro Ile Thr 
    12935                 12940                 12945             


Ser Cys   Ser Val Glu Lys Leu   Ile Glu Gly His Glu   Tyr Gln Phe 
    12950                 12955                 12960             


Arg Ile   Cys Ala Glu Asn Lys   Tyr Gly Val Gly Asp   Pro Val Phe 
    12965                 12970                 12975             


Thr Glu   Pro Ala Ile Ala Lys   Asn Pro Tyr Asp Pro   Pro Gly Arg 
    12980                 12985                 12990             


Cys Asp   Pro Pro Val Ile Ser   Asn Ile Thr Lys Asp   His Met Thr 
    12995                 13000                 13005             


Val Ser   Trp Lys Pro Pro Ala   Asp Asp Gly Gly Ser   Pro Ile Thr 
    13010                 13015                 13020             


Gly Tyr   Leu Leu Glu Lys Arg   Glu Thr Gln Ala Val   Asn Trp Thr 
    13025                 13030                 13035             


Lys Val   Asn Arg Lys Pro Ile   Ile Glu Arg Thr Leu   Lys Ala Thr 
    13040                 13045                 13050             


Gly Leu   Gln Glu Gly Thr Glu   Tyr Glu Phe Arg Val   Thr Ala Ile 
    13055                 13060                 13065             


Asn Lys   Ala Gly Pro Gly Lys   Pro Ser Asp Ala Ser   Lys Ala Ala 
    13070                 13075                 13080             


Tyr Ala   Arg Asp Pro Gln Tyr   Pro Pro Ala Pro Pro   Ala Phe Pro 
    13085                 13090                 13095             


Lys Val   Tyr Asp Thr Thr Arg   Ser Ser Val Ser Leu   Ser Trp Gly 
    13100                 13105                 13110             


Lys Pro   Ala Tyr Asp Gly Gly   Ser Pro Ile Ile Gly   Tyr Leu Val 
    13115                 13120                 13125             


Glu Val   Lys Arg Ala Asp Ser   Asp Asn Trp Val Arg   Cys Asn Leu 
    13130                 13135                 13140             


Pro Gln   Asn Leu Gln Lys Thr   Arg Phe Glu Val Thr   Gly Leu Met 
    13145                 13150                 13155             


Glu Asp   Thr Gln Tyr Gln Phe   Arg Val Tyr Ala Val   Asn Lys Ile 
    13160                 13165                 13170             


Gly Tyr   Ser Asp Pro Ser Asp   Val Pro Asp Lys His   Tyr Pro Lys 
    13175                 13180                 13185             


Asp Ile   Leu Ile Pro Pro Glu   Gly Glu Leu Asp Ala   Asp Leu Arg 
    13190                 13195                 13200             


Lys Thr   Leu Ile Leu Arg Ala   Gly Val Thr Met Arg   Leu Tyr Val 
    13205                 13210                 13215             


Pro Val   Lys Gly Arg Pro Pro   Pro Lys Ile Thr Trp   Ser Lys Pro 
    13220                 13225                 13230             


Asn Val   Asn Leu Arg Asp Arg   Ile Gly Leu Asp Ile   Lys Ser Thr 
    13235                 13240                 13245             


Asp Phe   Asp Thr Phe Leu Arg   Cys Glu Asn Val Asn   Lys Tyr Asp 
    13250                 13255                 13260             


Ala Gly   Lys Tyr Ile Leu Thr   Leu Glu Asn Ser Cys   Gly Lys Lys 
    13265                 13270                 13275             


Glu Tyr   Thr Ile Val Val Lys   Val Leu Asp Thr Pro   Gly Pro Pro 
    13280                 13285                 13290             


Val Asn   Val Thr Val Lys Glu   Ile Ser Lys Asp Ser   Ala Tyr Val 
    13295                 13300                 13305             


Thr Trp   Glu Pro Pro Ile Ile   Asp Gly Gly Ser Pro   Ile Ile Asn 
    13310                 13315                 13320             


Tyr Val   Val Gln Lys Arg Asp   Ala Glu Arg Lys Ser   Trp Ser Thr 
    13325                 13330                 13335             


Val Thr   Thr Glu Cys Ser Lys   Thr Ser Phe Arg Val   Ala Asn Leu 
    13340                 13345                 13350             


Glu Glu   Gly Lys Ser Tyr Phe   Phe Arg Val Phe Ala   Glu Asn Glu 
    13355                 13360                 13365             


Tyr Gly   Ile Gly Asp Pro Gly   Glu Thr Arg Asp Ala   Val Lys Ala 
    13370                 13375                 13380             


Ser Gln   Thr Pro Gly Pro Val   Val Asp Leu Lys Val   Arg Ser Val 
    13385                 13390                 13395             


Ser Lys   Ser Ser Cys Ser Ile   Gly Trp Lys Lys Pro   His Ser Asp 
    13400                 13405                 13410             


Gly Gly   Ser Arg Ile Ile Gly   Tyr Val Val Asp Phe   Leu Thr Glu 
    13415                 13420                 13425             


Glu Asn   Lys Trp Gln Arg Val   Met Lys Ser Leu Ser   Leu Gln Tyr 
    13430                 13435                 13440             


Ser Ala   Lys Asp Leu Thr Glu   Gly Lys Glu Tyr Thr   Phe Arg Val 
    13445                 13450                 13455             


Ser Ala   Glu Asn Glu Asn Gly   Glu Gly Thr Pro Ser   Glu Ile Thr 
    13460                 13465                 13470             


Val Val   Ala Arg Asp Asp Val   Val Ala Pro Asp Leu   Asp Leu Lys 
    13475                 13480                 13485             


Gly Leu   Pro Asp Leu Cys Tyr   Leu Ala Lys Glu Asn   Ser Asn Phe 
    13490                 13495                 13500             


Arg Leu   Lys Ile Pro Ile Lys   Gly Lys Pro Ala Pro   Ser Val Ser 
    13505                 13510                 13515             


Trp Lys   Lys Gly Glu Asp Pro   Leu Ala Thr Asp Thr   Arg Val Ser 
    13520                 13525                 13530             


Val Glu   Ser Ser Ala Val Asn   Thr Thr Leu Ile Val   Tyr Asp Cys 
    13535                 13540                 13545             


Gln Lys   Ser Asp Ala Gly Lys   Tyr Thr Ile Thr Leu   Lys Asn Val 
    13550                 13555                 13560             


Ala Gly   Thr Lys Glu Gly Thr   Ile Ser Ile Lys Val   Val Gly Lys 
    13565                 13570                 13575             


Pro Gly   Ile Pro Thr Gly Pro   Ile Lys Phe Asp Glu   Val Thr Ala 
    13580                 13585                 13590             


Glu Ala   Met Thr Leu Lys Trp   Ala Pro Pro Lys Asp   Asp Gly Gly 
    13595                 13600                 13605             


Ser Glu   Ile Thr Asn Tyr Ile   Leu Glu Lys Arg Asp   Ser Val Asn 
    13610                 13615                 13620             


Asn Lys   Trp Val Thr Cys Ala   Ser Ala Val Gln Lys   Thr Thr Phe 
    13625                 13630                 13635             


Arg Val   Thr Arg Leu His Glu   Gly Met Glu Tyr Thr   Phe Arg Val 
    13640                 13645                 13650             


Ser Ala   Glu Asn Lys Tyr Gly   Val Gly Glu Gly Leu   Lys Ser Glu 
    13655                 13660                 13665             


Pro Ile   Val Ala Arg His Pro   Phe Asp Val Pro Asp   Ala Pro Pro 
    13670                 13675                 13680             


Pro Pro   Asn Ile Val Asp Val   Arg His Asp Ser Val   Ser Leu Thr 
    13685                 13690                 13695             


Trp Thr   Asp Pro Lys Lys Thr   Gly Gly Ser Pro Ile   Thr Gly Tyr 
    13700                 13705                 13710             


His Leu   Glu Phe Lys Glu Arg   Asn Ser Leu Leu Trp   Lys Arg Ala 
    13715                 13720                 13725             


Asn Lys   Thr Pro Ile Arg Met   Arg Asp Phe Lys Val   Thr Gly Leu 
    13730                 13735                 13740             


Thr Glu   Gly Leu Glu Tyr Glu   Phe Arg Val Met Ala   Ile Asn Leu 
    13745                 13750                 13755             


Ala Gly   Val Gly Lys Pro Ser   Leu Pro Ser Glu Pro   Val Val Ala 
    13760                 13765                 13770             


Leu Asp   Pro Ile Asp Pro Pro   Gly Lys Pro Glu Val   Ile Asn Ile 
    13775                 13780                 13785             


Thr Arg   Asn Ser Val Thr Leu   Ile Trp Thr Glu Pro   Lys Tyr Asp 
    13790                 13795                 13800             


Gly Gly   His Lys Leu Thr Gly   Tyr Ile Val Glu Lys   Arg Asp Leu 
    13805                 13810                 13815             


Pro Ser   Lys Ser Trp Met Lys   Ala Asn His Val Asn   Val Pro Glu 
    13820                 13825                 13830             


Cys Ala   Phe Thr Val Thr Asp   Leu Val Glu Gly Gly   Lys Tyr Glu 
    13835                 13840                 13845             


Phe Arg   Ile Arg Ala Lys Asn   Thr Ala Gly Ala Ile   Ser Ala Pro 
    13850                 13855                 13860             


Ser Glu   Ser Thr Glu Thr Ile   Ile Cys Lys Asp Glu   Tyr Glu Ala 
    13865                 13870                 13875             


Pro Thr   Ile Val Leu Asp Pro   Thr Ile Lys Asp Gly   Leu Thr Ile 
    13880                 13885                 13890             


Lys Ala   Gly Asp Thr Ile Val   Leu Asn Ala Ile Ser   Ile Leu Gly 
    13895                 13900                 13905             


Lys Pro   Leu Pro Lys Ser Ser   Trp Ser Lys Ala Gly   Lys Asp Ile 
    13910                 13915                 13920             


Arg Pro   Ser Asp Ile Thr Gln   Ile Thr Ser Thr Pro   Thr Ser Ser 
    13925                 13930                 13935             


Met Leu   Thr Ile Lys Tyr Ala   Thr Arg Lys Asp Ala   Gly Glu Tyr 
    13940                 13945                 13950             


Thr Ile   Thr Ala Thr Asn Pro   Phe Gly Thr Lys Val   Glu His Val 
    13955                 13960                 13965             


Lys Val   Thr Val Leu Asp Val   Pro Gly Pro Pro Gly   Pro Val Glu 
    13970                 13975                 13980             


Ile Ser   Asn Val Ser Ala Glu   Lys Ala Thr Leu Thr   Trp Thr Pro 
    13985                 13990                 13995             


Pro Leu   Glu Asp Gly Gly Ser   Pro Ile Lys Ser Tyr   Ile Leu Glu 
    14000                 14005                 14010             


Lys Arg   Glu Thr Ser Arg Leu   Leu Trp Thr Val Val   Ser Glu Asp 
    14015                 14020                 14025             


Ile Gln   Ser Cys Arg His Val   Ala Thr Lys Leu Ile   Gln Gly Asn 
    14030                 14035                 14040             


Glu Tyr   Ile Phe Arg Val Ser   Ala Val Asn His Tyr   Gly Lys Gly 
    14045                 14050                 14055             


Glu Pro   Val Gln Ser Glu Pro   Val Lys Met Val Asp   Arg Phe Gly 
    14060                 14065                 14070             


Pro Pro   Gly Pro Pro Glu Lys   Pro Glu Val Ser Asn   Val Thr Lys 
    14075                 14080                 14085             


Asn Thr   Ala Thr Val Ser Trp   Lys Arg Pro Val Asp   Asp Gly Gly 
    14090                 14095                 14100             


Ser Glu   Ile Thr Gly Tyr His   Val Glu Arg Arg Glu   Lys Lys Ser 
    14105                 14110                 14115             


Leu Arg   Trp Val Arg Ala Ile   Lys Thr Pro Val Ser   Asp Leu Arg 
    14120                 14125                 14130             


Cys Lys   Val Thr Gly Leu Gln   Glu Gly Ser Thr Tyr   Glu Phe Arg 
    14135                 14140                 14145             


Val Ser   Ala Glu Asn Arg Ala   Gly Ile Gly Pro Pro   Ser Glu Ala 
    14150                 14155                 14160             


Ser Asp   Ser Val Leu Met Lys   Asp Ala Ala Tyr Pro   Pro Gly Pro 
    14165                 14170                 14175             


Pro Ser   Asn Pro His Val Thr   Asp Thr Thr Lys Lys   Ser Ala Ser 
    14180                 14185                 14190             


Leu Ala   Trp Gly Lys Pro His   Tyr Asp Gly Gly Leu   Glu Ile Thr 
    14195                 14200                 14205             


Gly Tyr   Val Val Glu His Gln   Lys Val Gly Asp Glu   Ala Trp Ile 
    14210                 14215                 14220             


Lys Asp   Thr Thr Gly Thr Ala   Leu Arg Ile Thr Gln   Phe Val Val 
    14225                 14230                 14235             


Pro Asp   Leu Gln Thr Lys Glu   Lys Tyr Asn Phe Arg   Ile Ser Ala 
    14240                 14245                 14250             


Ile Asn   Asp Ala Gly Val Gly   Glu Pro Ala Val Ile   Pro Asp Val 
    14255                 14260                 14265             


Glu Ile   Val Glu Arg Glu Met   Ala Pro Asp Phe Glu   Leu Asp Ala 
    14270                 14275                 14280             


Glu Leu   Arg Arg Thr Leu Val   Val Arg Ala Gly Leu   Ser Ile Arg 
    14285                 14290                 14295             


Ile Phe   Val Pro Ile Lys Gly   Arg Pro Ala Pro Glu   Val Thr Trp 
    14300                 14305                 14310             


Thr Lys   Asp Asn Ile Asn Leu   Lys Asn Arg Ala Asn   Ile Glu Asn 
    14315                 14320                 14325             


Thr Glu   Ser Phe Thr Leu Leu   Ile Ile Pro Glu Cys   Asn Arg Tyr 
    14330                 14335                 14340             


Asp Thr   Gly Lys Phe Val Met   Thr Ile Glu Asn Pro   Ala Gly Lys 
    14345                 14350                 14355             


Lys Ser   Gly Phe Val Asn Val   Arg Val Leu Asp Thr   Pro Gly Pro 
    14360                 14365                 14370             


Val Leu   Asn Leu Arg Pro Thr   Asp Ile Thr Lys Asp   Ser Val Thr 
    14375                 14380                 14385             


Leu His   Trp Asp Leu Pro Leu   Ile Asp Gly Gly Ser   Arg Ile Thr 
    14390                 14395                 14400             


Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Thr Arg Lys   Ser Tyr Ser 
    14405                 14410                 14415             


Thr Ala   Thr Thr Lys Cys His   Lys Cys Thr Tyr Lys   Val Thr Gly 
    14420                 14425                 14430             


Leu Ser   Glu Gly Cys Glu Tyr   Phe Phe Arg Val Met   Ala Glu Asn 
    14435                 14440                 14445             


Glu Tyr   Gly Ile Gly Glu Pro   Thr Glu Thr Thr Glu   Pro Val Lys 
    14450                 14455                 14460             


Ala Ser   Glu Ala Pro Ser Pro   Pro Asp Ser Leu Asn   Ile Met Asp 
    14465                 14470                 14475             


Ile Thr   Lys Ser Thr Val Ser   Leu Ala Trp Pro Lys   Pro Lys His 
    14480                 14485                 14490             


Asp Gly   Gly Ser Lys Ile Thr   Gly Tyr Val Ile Glu   Ala Gln Arg 
    14495                 14500                 14505             


Lys Gly   Ser Asp Gln Trp Thr   His Ile Thr Thr Val   Lys Gly Leu 
    14510                 14515                 14520             


Glu Cys   Val Val Arg Asn Leu   Thr Glu Gly Glu Glu   Tyr Thr Phe 
    14525                 14530                 14535             


Gln Val   Met Ala Val Asn Ser   Ala Gly Arg Ser Ala   Pro Arg Glu 
    14540                 14545                 14550             


Ser Arg   Pro Val Ile Val Lys   Glu Gln Thr Met Leu   Pro Glu Leu 
    14555                 14560                 14565             


Asp Leu   Arg Gly Ile Tyr Gln   Lys Leu Val Ile Ala   Lys Ala Gly 
    14570                 14575                 14580             


Asp Asn   Ile Lys Val Glu Ile   Pro Val Leu Gly Arg   Pro Lys Pro 
    14585                 14590                 14595             


Thr Val   Thr Trp Lys Lys Gly   Asp Gln Ile Leu Lys   Gln Thr Gln 
    14600                 14605                 14610             


Arg Val   Asn Phe Glu Thr Thr   Ala Thr Ser Thr Ile   Leu Asn Ile 
    14615                 14620                 14625             


Asn Glu   Cys Val Arg Ser Asp   Ser Gly Pro Tyr Pro   Leu Thr Ala 
    14630                 14635                 14640             


Arg Asn   Ile Val Gly Glu Val   Gly Asp Val Ile Thr   Ile Gln Val 
    14645                 14650                 14655             


His Asp   Ile Pro Gly Pro Pro   Thr Gly Pro Ile Lys   Phe Asp Glu 
    14660                 14665                 14670             


Val Ser   Ser Asp Phe Val Thr   Phe Ser Trp Asp Pro   Pro Glu Asn 
    14675                 14680                 14685             


Asp Gly   Gly Val Pro Ile Ser   Asn Tyr Val Val Glu   Met Arg Gln 
    14690                 14695                 14700             


Thr Asp   Ser Thr Thr Trp Val   Glu Leu Ala Thr Thr   Val Ile Arg 
    14705                 14710                 14715             


Thr Thr   Tyr Lys Ala Thr Arg   Leu Thr Thr Gly Leu   Glu Tyr Gln 
    14720                 14725                 14730             


Phe Arg   Val Lys Ala Gln Asn   Arg Tyr Gly Val Gly   Pro Gly Ile 
    14735                 14740                 14745             


Thr Ser   Ala Cys Ile Val Ala   Asn Tyr Pro Phe Lys   Val Pro Gly 
    14750                 14755                 14760             


Pro Pro   Gly Thr Pro Gln Val   Thr Ala Val Thr Lys   Asp Ser Met 
    14765                 14770                 14775             


Thr Ile   Ser Trp His Glu Pro   Leu Ser Asp Gly Gly   Ser Pro Ile 
    14780                 14785                 14790             


Leu Gly   Tyr His Val Glu Arg   Lys Glu Arg Asn Gly   Ile Leu Trp 
    14795                 14800                 14805             


Gln Thr   Val Ser Lys Ala Leu   Val Pro Gly Asn Ile   Phe Lys Ser 
    14810                 14815                 14820             


Ser Gly   Leu Thr Asp Gly Ile   Ala Tyr Glu Phe Arg   Val Ile Ala 
    14825                 14830                 14835             


Glu Asn   Met Ala Gly Lys Ser   Lys Pro Ser Lys Pro   Ser Glu Pro 
    14840                 14845                 14850             


Met Leu   Ala Leu Asp Pro Ile   Asp Pro Pro Gly Lys   Pro Val Pro 
    14855                 14860                 14865             


Leu Asn   Ile Thr Arg His Thr   Val Thr Leu Lys Trp   Ala Lys Pro 
    14870                 14875                 14880             


Glu Tyr   Thr Gly Gly Phe Lys   Ile Thr Ser Tyr Ile   Val Glu Lys 
    14885                 14890                 14895             


Arg Asp   Leu Pro Asn Gly Arg   Trp Leu Lys Ala Asn   Phe Ser Asn 
    14900                 14905                 14910             


Ile Leu   Glu Asn Glu Phe Thr   Val Ser Gly Leu Thr   Glu Asp Ala 
    14915                 14920                 14925             


Ala Tyr   Glu Phe Arg Val Ile   Ala Lys Asn Ala Ala   Gly Ala Ile 
    14930                 14935                 14940             


Ser Pro   Pro Ser Glu Pro Ser   Asp Ala Ile Thr Cys   Arg Asp Asp 
    14945                 14950                 14955             


Val Glu   Ala Pro Lys Ile Lys   Val Asp Val Lys Phe   Lys Asp Thr 
    14960                 14965                 14970             


Val Ile   Leu Lys Ala Gly Glu   Ala Phe Arg Leu Glu   Ala Asp Val 
    14975                 14980                 14985             


Ser Gly   Arg Pro Pro Pro Thr   Met Glu Trp Ser Lys   Asp Gly Lys 
    14990                 14995                 15000             


Glu Leu   Glu Gly Thr Ala Lys   Leu Glu Ile Lys Ile   Ala Asp Phe 
    15005                 15010                 15015             


Ser Thr   Asn Leu Val Asn Lys   Asp Ser Thr Arg Arg   Asp Ser Gly 
    15020                 15025                 15030             


Ala Tyr   Thr Leu Thr Ala Thr   Asn Pro Gly Gly Phe   Ala Lys His 
    15035                 15040                 15045             


Ile Phe   Asn Val Lys Val Leu   Asp Arg Pro Gly Pro   Pro Glu Gly 
    15050                 15055                 15060             


Pro Leu   Ala Val Thr Glu Val   Thr Ser Glu Lys Cys   Val Leu Ser 
    15065                 15070                 15075             


Trp Phe   Pro Pro Leu Asp Asp   Gly Gly Ala Lys Ile   Asp His Tyr 
    15080                 15085                 15090             


Ile Val   Gln Lys Arg Glu Thr   Ser Arg Leu Ala Trp   Thr Asn Val 
    15095                 15100                 15105             


Ala Ser   Glu Val Gln Val Thr   Lys Leu Lys Val Thr   Lys Leu Leu 
    15110                 15115                 15120             


Lys Gly   Asn Glu Tyr Ile Phe   Arg Val Met Ala Val   Asn Lys Tyr 
    15125                 15130                 15135             


Gly Val   Gly Glu Pro Leu Glu   Ser Glu Pro Val Leu   Ala Val Asn 
    15140                 15145                 15150             


Pro Tyr   Gly Pro Pro Asp Pro   Pro Lys Asn Pro Glu   Val Thr Thr 
    15155                 15160                 15165             


Ile Thr   Lys Asp Ser Met Val   Val Cys Trp Gly His   Pro Asp Ser 
    15170                 15175                 15180             


Asp Gly   Gly Ser Glu Ile Ile   Asn Tyr Ile Val Glu   Arg Arg Asp 
    15185                 15190                 15195             


Lys Ala   Gly Gln Arg Trp Ile   Lys Cys Asn Lys Lys   Thr Leu Thr 
    15200                 15205                 15210             


Asp Leu   Arg Tyr Lys Val Ser   Gly Leu Thr Glu Gly   His Glu Tyr 
    15215                 15220                 15225             


Glu Phe   Arg Ile Met Ala Glu   Asn Ala Ala Gly Ile   Ser Ala Pro 
    15230                 15235                 15240             


Ser Pro   Thr Ser Pro Phe Tyr   Lys Ala Cys Asp Thr   Val Phe Lys 
    15245                 15250                 15255             


Pro Gly   Pro Pro Gly Asn Pro   Arg Val Leu Asp Thr   Ser Arg Ser 
    15260                 15265                 15270             


Ser Ile   Ser Ile Ala Trp Asn   Lys Pro Ile Tyr Asp   Gly Gly Ser 
    15275                 15280                 15285             


Glu Ile   Thr Gly Tyr Met Val   Glu Ile Ala Leu Pro   Glu Glu Asp 
    15290                 15295                 15300             


Glu Trp   Gln Ile Val Thr Pro   Pro Ala Gly Leu Lys   Ala Thr Ser 
    15305                 15310                 15315             


Tyr Thr   Ile Thr Gly Leu Thr   Glu Asn Gln Glu Tyr   Lys Ile Arg 
    15320                 15325                 15330             


Ile Tyr   Ala Met Asn Ser Glu   Gly Leu Gly Glu Pro   Ala Leu Val 
    15335                 15340                 15345             


Pro Gly   Thr Pro Lys Ala Glu   Asp Arg Met Leu Pro   Pro Glu Ile 
    15350                 15355                 15360             


Glu Leu   Asp Ala Asp Leu Arg   Lys Val Val Thr Ile   Arg Ala Cys 
    15365                 15370                 15375             


Cys Thr   Leu Arg Leu Phe Val   Pro Ile Lys Gly Arg   Pro Ala Pro 
    15380                 15385                 15390             


Glu Val   Lys Trp Ala Arg Asp   His Gly Glu Ser Leu   Asp Lys Ala 
    15395                 15400                 15405             


Ser Ile   Glu Ser Thr Ser Ser   Tyr Thr Leu Leu Ile   Val Gly Asn 
    15410                 15415                 15420             


Val Asn   Arg Phe Asp Ser Gly   Lys Tyr Ile Leu Thr   Val Glu Asn 
    15425                 15430                 15435             


Ser Ser   Gly Ser Lys Ser Ala   Phe Val Asn Val Arg   Val Leu Asp 
    15440                 15445                 15450             


Thr Pro   Gly Pro Pro Gln Asp   Leu Lys Val Lys Glu   Val Thr Lys 
    15455                 15460                 15465             


Thr Ser   Val Thr Leu Thr Trp   Asp Pro Pro Leu Leu   Asp Gly Gly 
    15470                 15475                 15480             


Ser Lys   Ile Lys Asn Tyr Ile   Val Glu Lys Arg Glu   Ser Thr Arg 
    15485                 15490                 15495             


Lys Ala   Tyr Ser Thr Val Ala   Thr Asn Cys His Lys   Thr Ser Trp 
    15500                 15505                 15510             


Lys Val   Asp Gln Leu Gln Glu   Gly Cys Ser Tyr Tyr   Phe Arg Val 
    15515                 15520                 15525             


Leu Ala   Glu Asn Glu Tyr Gly   Ile Gly Leu Pro Ala   Glu Thr Ala 
    15530                 15535                 15540             


Glu Ser   Val Lys Ala Ser Glu   Arg Pro Leu Pro Pro   Gly Lys Ile 
    15545                 15550                 15555             


Thr Leu   Met Asp Val Thr Arg   Asn Ser Val Ser Leu   Ser Trp Glu 
    15560                 15565                 15570             


Lys Pro   Glu His Asp Gly Gly   Ser Arg Ile Leu Gly   Tyr Ile Val 
    15575                 15580                 15585             


Glu Met   Gln Thr Lys Gly Ser   Asp Lys Trp Ala Thr   Cys Ala Thr 
    15590                 15595                 15600             


Val Lys   Val Thr Glu Ala Thr   Ile Thr Gly Leu Ile   Gln Gly Glu 
    15605                 15610                 15615             


Glu Tyr   Ser Phe Arg Val Ser   Ala Gln Asn Glu Lys   Gly Ile Ser 
    15620                 15625                 15630             


Asp Pro   Arg Gln Leu Ser Val   Pro Val Ile Ala Lys   Asp Leu Val 
    15635                 15640                 15645             


Ile Pro   Pro Ala Phe Lys Leu   Leu Phe Asn Thr Phe   Thr Val Leu 
    15650                 15655                 15660             


Ala Gly   Glu Asp Leu Lys Val   Asp Val Pro Phe Ile   Gly Arg Pro 
    15665                 15670                 15675             


Thr Pro   Ala Val Thr Trp His   Lys Asp Asn Val Pro   Leu Lys Gln 
    15680                 15685                 15690             


Thr Thr   Arg Val Asn Ala Glu   Ser Thr Glu Asn Asn   Ser Leu Leu 
    15695                 15700                 15705             


Thr Ile   Lys Asp Ala Cys Arg   Glu Asp Val Gly His   Tyr Val Val 
    15710                 15715                 15720             


Lys Leu   Thr Asn Ser Ala Gly   Glu Ala Ile Glu Thr   Leu Asn Val 
    15725                 15730                 15735             


Ile Val   Leu Asp Lys Pro Gly   Pro Pro Thr Gly Pro   Val Lys Met 
    15740                 15745                 15750             


Asp Glu   Val Thr Ala Asp Ser   Ile Thr Leu Ser Trp   Gly Pro Pro 
    15755                 15760                 15765             


Lys Tyr   Asp Gly Gly Ser Ser   Ile Asn Asn Tyr Ile   Val Glu Lys 
    15770                 15775                 15780             


Arg Asp   Thr Ser Thr Thr Thr   Trp Gln Ile Val Ser   Ala Thr Val 
    15785                 15790                 15795             


Ala Arg   Thr Thr Ile Lys Ala   Cys Arg Leu Lys Thr   Gly Cys Glu 
    15800                 15805                 15810             


Tyr Gln   Phe Arg Ile Ala Ala   Glu Asn Arg Tyr Gly   Lys Ser Thr 
    15815                 15820                 15825             


Tyr Leu   Asn Ser Glu Pro Thr   Val Ala Gln Tyr Pro   Phe Lys Val 
    15830                 15835                 15840             


Pro Gly   Pro Pro Gly Thr Pro   Val Val Thr Leu Ser   Ser Arg Asp 
    15845                 15850                 15855             


Ser Met   Glu Val Gln Trp Asn   Glu Pro Ile Ser Asp   Gly Gly Ser 
    15860                 15865                 15870             


Arg Val   Ile Gly Tyr His Leu   Glu Arg Lys Glu Arg   Asn Ser Ile 
    15875                 15880                 15885             


Leu Trp   Val Lys Leu Asn Lys   Thr Pro Ile Pro Gln   Thr Lys Phe 
    15890                 15895                 15900             


Lys Thr   Thr Gly Leu Glu Glu   Gly Val Glu Tyr Glu   Phe Arg Val 
    15905                 15910                 15915             


Ser Ala   Glu Asn Ile Val Gly   Ile Gly Lys Pro Ser   Lys Val Ser 
    15920                 15925                 15930             


Glu Cys   Tyr Val Ala Arg Asp   Pro Cys Asp Pro Pro   Gly Arg Pro 
    15935                 15940                 15945             


Glu Ala   Ile Ile Val Thr Arg   Asn Ser Val Thr Leu   Gln Trp Lys 
    15950                 15955                 15960             


Lys Pro   Thr Tyr Asp Gly Gly   Ser Lys Ile Thr Gly   Tyr Ile Val 
    15965                 15970                 15975             


Glu Lys   Lys Glu Leu Pro Glu   Gly Arg Trp Met Lys   Ala Ser Phe 
    15980                 15985                 15990             


Thr Asn   Ile Ile Asp Thr His   Phe Glu Val Thr Gly   Leu Val Glu 
    15995                 16000                 16005             


Asp His   Arg Tyr Glu Phe Arg   Val Ile Ala Arg Asn   Ala Ala Gly 
    16010                 16015                 16020             


Val Phe   Ser Glu Pro Ser Glu   Ser Thr Gly Ala Ile   Thr Ala Arg 
    16025                 16030                 16035             


Asp Glu   Val Asp Pro Pro Arg   Ile Ser Met Asp Pro   Lys Tyr Lys 
    16040                 16045                 16050             


Asp Thr   Ile Val Val His Ala   Gly Glu Ser Phe Lys   Val Asp Ala 
    16055                 16060                 16065             


Asp Ile   Tyr Gly Lys Pro Ile   Pro Thr Ile Gln Trp   Ile Lys Gly 
    16070                 16075                 16080             


Asp Gln   Glu Leu Ser Asn Thr   Ala Arg Leu Glu Ile   Lys Ser Thr 
    16085                 16090                 16095             


Asp Phe   Ala Thr Ser Leu Ser   Val Lys Asp Ala Val   Arg Val Asp 
    16100                 16105                 16110             


Ser Gly   Asn Tyr Ile Leu Lys   Ala Lys Asn Val Ala   Gly Glu Arg 
    16115                 16120                 16125             


Ser Val   Thr Val Asn Val Lys   Val Leu Asp Arg Pro   Gly Pro Pro 
    16130                 16135                 16140             


Glu Gly   Pro Val Val Ile Ser   Gly Val Thr Ala Glu   Lys Cys Thr 
    16145                 16150                 16155             


Leu Ala   Trp Lys Pro Pro Leu   Gln Asp Gly Gly Ser   Asp Ile Ile 
    16160                 16165                 16170             


Asn Tyr   Ile Val Glu Arg Arg   Glu Thr Ser Arg Leu   Val Trp Thr 
    16175                 16180                 16185             


Val Val   Asp Ala Asn Val Gln   Thr Leu Ser Cys Lys   Val Thr Lys 
    16190                 16195                 16200             


Leu Leu   Glu Gly Asn Glu Tyr   Thr Phe Arg Ile Met   Ala Val Asn 
    16205                 16210                 16215             


Lys Tyr   Gly Val Gly Glu Pro   Leu Glu Ser Glu Pro   Val Val Ala 
    16220                 16225                 16230             


Lys Asn   Pro Phe Val Val Pro   Asp Ala Pro Lys Ala   Pro Glu Val 
    16235                 16240                 16245             


Thr Thr   Val Thr Lys Asp Ser   Met Ile Val Val Trp   Glu Arg Pro 
    16250                 16255                 16260             


Ala Ser   Asp Gly Gly Ser Glu   Ile Leu Gly Tyr Val   Leu Glu Lys 
    16265                 16270                 16275             


Arg Asp   Lys Glu Gly Ile Arg   Trp Thr Arg Cys His   Lys Arg Leu 
    16280                 16285                 16290             


Ile Gly   Glu Leu Arg Leu Arg   Val Thr Gly Leu Ile   Glu Asn His 
    16295                 16300                 16305             


Asp Tyr   Glu Phe Arg Val Ser   Ala Glu Asn Ala Ala   Gly Leu Ser 
    16310                 16315                 16320             


Glu Pro   Ser Pro Pro Ser Ala   Tyr Gln Lys Ala Cys   Asp Pro Ile 
    16325                 16330                 16335             


Tyr Lys   Pro Gly Pro Pro Asn   Asn Pro Lys Val Ile   Asp Ile Thr 
    16340                 16345                 16350             


Arg Ser   Ser Val Phe Leu Ser   Trp Ser Lys Pro Ile   Tyr Asp Gly 
    16355                 16360                 16365             


Gly Cys   Glu Ile Gln Gly Tyr   Ile Val Glu Lys Cys   Asp Val Ser 
    16370                 16375                 16380             


Val Gly   Glu Trp Thr Met Cys   Thr Pro Pro Thr Gly   Ile Asn Lys 
    16385                 16390                 16395             


Thr Asn   Ile Glu Val Glu Lys   Leu Leu Glu Lys His   Glu Tyr Asn 
    16400                 16405                 16410             


Phe Arg   Ile Cys Ala Ile Asn   Lys Ala Gly Val Gly   Glu His Ala 
    16415                 16420                 16425             


Asp Val   Pro Gly Pro Ile Ile   Val Glu Glu Lys Leu   Glu Ala Pro 
    16430                 16435                 16440             


Asp Ile   Asp Leu Asp Leu Glu   Leu Arg Lys Ile Ile   Asn Ile Arg 
    16445                 16450                 16455             


Ala Gly   Gly Ser Leu Arg Leu   Phe Val Pro Ile Lys   Gly Arg Pro 
    16460                 16465                 16470             


Thr Pro   Glu Val Lys Trp Gly   Lys Val Asp Gly Glu   Ile Arg Asp 
    16475                 16480                 16485             


Ala Ala   Ile Ile Asp Val Thr   Ser Ser Phe Thr Ser   Leu Val Leu 
    16490                 16495                 16500             


Asp Asn   Val Asn Arg Tyr Asp   Ser Gly Lys Tyr Thr   Leu Thr Leu 
    16505                 16510                 16515             


Glu Asn   Ser Ser Gly Thr Lys   Ser Ala Phe Val Thr   Val Arg Val 
    16520                 16525                 16530             


Leu Asp   Thr Pro Ser Pro Pro   Val Asn Leu Lys Val   Thr Glu Ile 
    16535                 16540                 16545             


Thr Lys   Asp Ser Val Ser Ile   Thr Trp Glu Pro Pro   Leu Leu Asp 
    16550                 16555                 16560             


Gly Gly   Ser Lys Ile Lys Asn   Tyr Ile Val Glu Lys   Arg Glu Ala 
    16565                 16570                 16575             


Thr Arg   Lys Ser Tyr Ala Ala   Val Val Thr Asn Cys   His Lys Asn 
    16580                 16585                 16590             


Ser Trp   Lys Ile Asp Gln Leu   Gln Glu Gly Cys Ser   Tyr Tyr Phe 
    16595                 16600                 16605             


Arg Val   Thr Ala Glu Asn Glu   Tyr Gly Ile Gly Leu   Pro Ala Gln 
    16610                 16615                 16620             


Thr Ala   Asp Pro Ile Lys Val   Ala Glu Val Pro Gln   Pro Pro Gly 
    16625                 16630                 16635             


Lys Ile   Thr Val Asp Asp Val   Thr Arg Asn Ser Val   Ser Leu Ser 
    16640                 16645                 16650             


Trp Thr   Lys Pro Glu His Asp   Gly Gly Ser Lys Ile   Ile Gln Tyr 
    16655                 16660                 16665             


Ile Val   Glu Met Gln Ala Lys   His Ser Glu Lys Trp   Ser Glu Cys 
    16670                 16675                 16680             


Ala Arg   Val Lys Ser Leu Gln   Ala Val Ile Thr Asn   Leu Thr Gln 
    16685                 16690                 16695             


Gly Glu   Glu Tyr Leu Phe Arg   Val Val Ala Val Asn   Glu Lys Gly 
    16700                 16705                 16710             


Arg Ser   Asp Pro Arg Ser Leu   Ala Val Pro Ile Val   Ala Lys Asp 
    16715                 16720                 16725             


Leu Val   Ile Glu Pro Asp Val   Lys Pro Ala Phe Ser   Ser Tyr Ser 
    16730                 16735                 16740             


Val Gln   Val Gly Gln Asp Leu   Lys Ile Glu Val Pro   Ile Ser Gly 
    16745                 16750                 16755             


Arg Pro   Lys Pro Thr Ile Thr   Trp Thr Lys Asp Gly   Leu Pro Leu 
    16760                 16765                 16770             


Lys Gln   Thr Thr Arg Ile Asn   Val Thr Asp Ser Leu   Asp Leu Thr 
    16775                 16780                 16785             


Thr Leu   Ser Ile Lys Glu Thr   His Lys Asp Asp Gly   Gly Gln Tyr 
    16790                 16795                 16800             


Gly Ile   Thr Val Ala Asn Val   Val Gly Gln Lys Thr   Ala Ser Ile 
    16805                 16810                 16815             


Glu Ile   Val Thr Leu Asp Lys   Pro Asp Pro Pro Lys   Gly Pro Val 
    16820                 16825                 16830             


Lys Phe   Asp Asp Val Ser Ala   Glu Ser Ile Thr Leu   Ser Trp Asn 
    16835                 16840                 16845             


Pro Pro   Leu Tyr Thr Gly Gly   Cys Gln Ile Thr Asn   Tyr Ile Val 
    16850                 16855                 16860             


Gln Lys   Arg Asp Thr Thr Thr   Thr Val Trp Asp Val   Val Ser Ala 
    16865                 16870                 16875             


Thr Val   Ala Arg Thr Thr Leu   Lys Val Thr Lys Leu   Lys Thr Gly 
    16880                 16885                 16890             


Thr Glu   Tyr Gln Phe Arg Ile   Phe Ala Glu Asn Arg   Tyr Gly Gln 
    16895                 16900                 16905             


Ser Phe   Ala Leu Glu Ser Asp   Pro Ile Val Ala Gln   Tyr Pro Tyr 
    16910                 16915                 16920             


Lys Glu   Pro Gly Pro Pro Gly   Thr Pro Phe Ala Thr   Ala Ile Ser 
    16925                 16930                 16935             


Lys Asp   Ser Met Val Ile Gln   Trp His Glu Pro Val   Asn Asn Gly 
    16940                 16945                 16950             


Gly Ser   Pro Val Ile Gly Tyr   His Leu Glu Arg Lys   Glu Arg Asn 
    16955                 16960                 16965             


Ser Ile   Leu Trp Thr Lys Val   Asn Lys Thr Ile Ile   His Asp Thr 
    16970                 16975                 16980             


Gln Phe   Lys Ala Gln Asn Leu   Glu Glu Gly Ile Glu   Tyr Glu Phe 
    16985                 16990                 16995             


Arg Val   Tyr Ala Glu Asn Ile   Val Gly Val Gly Lys   Ala Ser Lys 
    17000                 17005                 17010             


Asn Ser   Glu Cys Tyr Val Ala   Arg Asp Pro Cys Asp   Pro Pro Gly 
    17015                 17020                 17025             


Thr Pro   Glu Pro Ile Met Val   Lys Arg Asn Glu Ile   Thr Leu Gln 
    17030                 17035                 17040             


Trp Thr   Lys Pro Val Tyr Asp   Gly Gly Ser Met Ile   Thr Gly Tyr 
    17045                 17050                 17055             


Ile Val   Glu Lys Arg Asp Leu   Pro Asp Gly Arg Trp   Met Lys Ala 
    17060                 17065                 17070             


Ser Phe   Thr Asn Val Ile Glu   Thr Gln Phe Thr Val   Ser Gly Leu 
    17075                 17080                 17085             


Thr Glu   Asp Gln Arg Tyr Glu   Phe Arg Val Ile Ala   Lys Asn Ala 
    17090                 17095                 17100             


Ala Gly   Ala Ile Ser Lys Pro   Ser Asp Ser Thr Gly   Pro Ile Thr 
    17105                 17110                 17115             


Ala Lys   Asp Glu Val Glu Leu   Pro Arg Ile Ser Met   Asp Pro Lys 
    17120                 17125                 17130             


Phe Arg   Asp Thr Ile Val Val   Asn Ala Gly Glu Thr   Phe Arg Leu 
    17135                 17140                 17145             


Glu Ala   Asp Val His Gly Lys   Pro Leu Pro Thr Ile   Glu Trp Leu 
    17150                 17155                 17160             


Arg Gly   Asp Lys Glu Ile Glu   Glu Ser Ala Arg Cys   Glu Ile Lys 
    17165                 17170                 17175             


Asn Thr   Asp Phe Lys Ala Leu   Leu Ile Val Lys Asp   Ala Ile Arg 
    17180                 17185                 17190             


Ile Asp   Gly Gly Gln Tyr Ile   Leu Arg Ala Ser Asn   Val Ala Gly 
    17195                 17200                 17205             


Ser Lys   Ser Phe Pro Val Asn   Val Lys Val Leu Asp   Arg Pro Gly 
    17210                 17215                 17220             


Pro Pro   Glu Gly Pro Val Gln   Val Thr Gly Val Thr   Ser Glu Lys 
    17225                 17230                 17235             


Cys Ser   Leu Thr Trp Ser Pro   Pro Leu Gln Asp Gly   Gly Ser Asp 
    17240                 17245                 17250             


Ile Ser   His Tyr Val Val Glu   Lys Arg Glu Thr Ser   Arg Leu Ala 
    17255                 17260                 17265             


Trp Thr   Val Val Ala Ser Glu   Val Val Thr Asn Ser   Leu Lys Val 
    17270                 17275                 17280             


Thr Lys   Leu Leu Glu Gly Asn   Glu Tyr Val Phe Arg   Ile Met Ala 
    17285                 17290                 17295             


Val Asn   Lys Tyr Gly Val Gly   Glu Pro Leu Glu Ser   Ala Pro Val 
    17300                 17305                 17310             


Leu Met   Lys Asn Pro Phe Val   Leu Pro Gly Pro Pro   Lys Ser Leu 
    17315                 17320                 17325             


Glu Val   Thr Asn Ile Ala Lys   Asp Ser Met Thr Val   Cys Trp Asn 
    17330                 17335                 17340             


Arg Pro   Asp Ser Asp Gly Gly   Ser Glu Ile Ile Gly   Tyr Ile Val 
    17345                 17350                 17355             


Glu Lys   Arg Asp Arg Ser Gly   Ile Arg Trp Ile Lys   Cys Asn Lys 
    17360                 17365                 17370             


Arg Arg   Ile Thr Asp Leu Arg   Leu Arg Val Thr Gly   Leu Thr Glu 
    17375                 17380                 17385             


Asp His   Glu Tyr Glu Phe Arg   Val Ser Ala Glu Asn   Ala Ala Gly 
    17390                 17395                 17400             


Val Gly   Glu Pro Ser Pro Ala   Thr Val Tyr Tyr Lys   Ala Cys Asp 
    17405                 17410                 17415             


Pro Val   Phe Lys Pro Gly Pro   Pro Thr Asn Ala His   Ile Val Asp 
    17420                 17425                 17430             


Thr Thr   Lys Asn Ser Ile Thr   Leu Ala Trp Gly Lys   Pro Ile Tyr 
    17435                 17440                 17445             


Asp Gly   Gly Ser Glu Ile Leu   Gly Tyr Val Val Glu   Ile Cys Lys 
    17450                 17455                 17460             


Ala Asp   Glu Glu Glu Trp Gln   Ile Val Thr Pro Gln   Thr Gly Leu 
    17465                 17470                 17475             


Arg Val   Thr Arg Phe Glu Ile   Ser Lys Leu Thr Glu   His Gln Glu 
    17480                 17485                 17490             


Tyr Lys   Ile Arg Val Cys Ala   Leu Asn Lys Val Gly   Leu Gly Glu 
    17495                 17500                 17505             


Ala Thr   Ser Val Pro Gly Thr   Val Lys Pro Glu Asp   Lys Leu Glu 
    17510                 17515                 17520             


Ala Pro   Glu Leu Asp Leu Asp   Ser Glu Leu Arg Lys   Gly Ile Val 
    17525                 17530                 17535             


Val Arg   Ala Gly Gly Ser Ala   Arg Ile His Ile Pro   Phe Lys Gly 
    17540                 17545                 17550             


Arg Pro   Thr Pro Glu Ile Thr   Trp Ser Arg Glu Glu   Gly Glu Phe 
    17555                 17560                 17565             


Thr Asp   Lys Val Gln Ile Glu   Lys Gly Val Asn Tyr   Thr Gln Leu 
    17570                 17575                 17580             


Ser Ile   Asp Asn Cys Asp Arg   Asn Asp Ala Gly Lys   Tyr Ile Leu 
    17585                 17590                 17595             


Lys Leu   Glu Asn Ser Ser Gly   Ser Lys Ser Ala Phe   Val Thr Val 
    17600                 17605                 17610             


Lys Val   Leu Asp Thr Pro Gly   Pro Pro Gln Asn Leu   Ala Val Lys 
    17615                 17620                 17625             


Glu Val   Arg Lys Asp Ser Ala   Phe Leu Val Trp Glu   Pro Pro Ile 
    17630                 17635                 17640             


Ile Asp   Gly Gly Ala Lys Val   Lys Asn Tyr Val Ile   Asp Lys Arg 
    17645                 17650                 17655             


Glu Ser   Thr Arg Lys Ala Tyr   Ala Asn Val Ser Ser   Lys Cys Ser 
    17660                 17665                 17670             


Lys Thr   Ser Phe Lys Val Glu   Asn Leu Thr Glu Gly   Ala Ile Tyr 
    17675                 17680                 17685             


Tyr Phe   Arg Val Met Ala Glu   Asn Glu Phe Gly Val   Gly Val Pro 
    17690                 17695                 17700             


Val Glu   Thr Val Asp Ala Val   Lys Ala Ala Glu Pro   Pro Ser Pro 
    17705                 17710                 17715             


Pro Gly   Lys Val Thr Leu Thr   Asp Val Ser Gln Thr   Ser Ala Ser 
    17720                 17725                 17730             


Leu Met   Trp Glu Lys Pro Glu   His Asp Gly Gly Ser   Arg Val Leu 
    17735                 17740                 17745             


Gly Tyr   Val Val Glu Met Gln   Pro Lys Gly Thr Glu   Lys Trp Ser 
    17750                 17755                 17760             


Ile Val   Ala Glu Ser Lys Val   Cys Asn Ala Val Val   Thr Gly Leu 
    17765                 17770                 17775             


Ser Ser   Gly Gln Glu Tyr Gln   Phe Arg Val Lys Ala   Tyr Asn Glu 
    17780                 17785                 17790             


Lys Gly   Lys Ser Asp Pro Arg   Val Leu Gly Val Pro   Val Ile Ala 
    17795                 17800                 17805             


Lys Asp   Leu Thr Ile Gln Pro   Ser Leu Lys Leu Pro   Phe Asn Thr 
    17810                 17815                 17820             


Tyr Ser   Ile Gln Ala Gly Glu   Asp Leu Lys Ile Glu   Ile Pro Val 
    17825                 17830                 17835             


Ile Gly   Arg Pro Arg Pro Asn   Ile Ser Trp Val Lys   Asp Gly Glu 
    17840                 17845                 17850             


Pro Leu   Lys Gln Thr Thr Arg   Val Asn Val Glu Glu   Thr Ala Thr 
    17855                 17860                 17865             


Ser Thr   Val Leu His Ile Lys   Glu Gly Asn Lys Asp   Asp Phe Gly 
    17870                 17875                 17880             


Lys Tyr   Thr Val Thr Ala Thr   Asn Ser Ala Gly Thr   Ala Thr Glu 
    17885                 17890                 17895             


Asn Leu   Ser Val Ile Val Leu   Glu Lys Pro Gly Pro   Pro Val Gly 
    17900                 17905                 17910             


Pro Val   Arg Phe Asp Glu Val   Ser Ala Asp Phe Val   Val Ile Ser 
    17915                 17920                 17925             


Trp Glu   Pro Pro Ala Tyr Thr   Gly Gly Cys Gln Ile   Ser Asn Tyr 
    17930                 17935                 17940             


Ile Val   Glu Lys Arg Asp Thr   Thr Thr Thr Thr Trp   His Met Val 
    17945                 17950                 17955             


Ser Ala   Thr Val Ala Arg Thr   Thr Ile Lys Ile Thr   Lys Leu Lys 
    17960                 17965                 17970             


Thr Gly   Thr Glu Tyr Gln Phe   Arg Ile Phe Ala Glu   Asn Arg Tyr 
    17975                 17980                 17985             


Gly Lys   Ser Ala Pro Leu Asp   Ser Lys Ala Val Ile   Val Gln Tyr 
    17990                 17995                 18000             


Pro Phe   Lys Glu Pro Gly Pro   Pro Gly Thr Pro Phe   Val Thr Ser 
    18005                 18010                 18015             


Ile Ser   Lys Asp Gln Met Leu   Val Gln Trp His Glu   Pro Val Asn 
    18020                 18025                 18030             


Asp Gly   Gly Thr Lys Ile Ile   Gly Tyr His Leu Glu   Gln Lys Glu 
    18035                 18040                 18045             


Lys Asn   Ser Ile Leu Trp Val   Lys Leu Asn Lys Thr   Pro Ile Gln 
    18050                 18055                 18060             


Asp Thr   Lys Phe Lys Thr Thr   Gly Leu Asp Glu Gly   Leu Glu Tyr 
    18065                 18070                 18075             


Glu Phe   Lys Val Ser Ala Glu   Asn Ile Val Gly Ile   Gly Lys Pro 
    18080                 18085                 18090             


Ser Lys   Val Ser Glu Cys Phe   Val Ala Arg Asp Pro   Cys Asp Pro 
    18095                 18100                 18105             


Pro Gly   Arg Pro Glu Ala Ile   Val Ile Thr Arg Asn   Asn Val Thr 
    18110                 18115                 18120             


Leu Lys   Trp Lys Lys Pro Ala   Tyr Asp Gly Gly Ser   Lys Ile Thr 
    18125                 18130                 18135             


Gly Tyr   Ile Val Glu Lys Lys   Asp Leu Pro Asp Gly   Arg Trp Met 
    18140                 18145                 18150             


Lys Ala   Ser Phe Thr Asn Val   Leu Glu Thr Glu Phe   Thr Val Ser 
    18155                 18160                 18165             


Gly Leu   Val Glu Asp Gln Arg   Tyr Glu Phe Arg Val   Ile Ala Arg 
    18170                 18175                 18180             


Asn Ala   Ala Gly Asn Phe Ser   Glu Pro Ser Asp Ser   Ser Gly Ala 
    18185                 18190                 18195             


Ile Thr   Ala Arg Asp Glu Ile   Asp Ala Pro Asn Ala   Ser Leu Asp 
    18200                 18205                 18210             


Pro Lys   Tyr Lys Asp Val Ile   Val Val His Ala Gly   Glu Thr Phe 
    18215                 18220                 18225             


Val Leu   Glu Ala Asp Ile Arg   Gly Lys Pro Ile Pro   Asp Val Val 
    18230                 18235                 18240             


Trp Ser   Lys Asp Gly Lys Glu   Leu Glu Glu Thr Ala   Ala Arg Met 
    18245                 18250                 18255             


Glu Ile   Lys Ser Thr Ile Gln   Lys Thr Thr Leu Val   Val Lys Asp 
    18260                 18265                 18270             


Cys Ile   Arg Thr Asp Gly Gly   Gln Tyr Ile Leu Lys   Leu Ser Asn 
    18275                 18280                 18285             


Val Gly   Gly Thr Lys Ser Ile   Pro Ile Thr Val Lys   Val Leu Asp 
    18290                 18295                 18300             


Arg Pro   Gly Pro Pro Glu Gly   Pro Leu Lys Val Thr   Gly Val Thr 
    18305                 18310                 18315             


Ala Glu   Lys Cys Tyr Leu Ala   Trp Asn Pro Pro Leu   Gln Asp Gly 
    18320                 18325                 18330             


Gly Ala   Asn Ile Ser His Tyr   Ile Ile Glu Lys Arg   Glu Thr Ser 
    18335                 18340                 18345             


Arg Leu   Ser Trp Thr Gln Val   Ser Thr Glu Val Gln   Ala Leu Asn 
    18350                 18355                 18360             


Tyr Lys   Val Thr Lys Leu Leu   Pro Gly Asn Glu Tyr   Ile Phe Arg 
    18365                 18370                 18375             


Val Met   Ala Val Asn Lys Tyr   Gly Ile Gly Glu Pro   Leu Glu Ser 
    18380                 18385                 18390             


Gly Pro   Val Thr Ala Cys Asn   Pro Tyr Lys Pro Pro   Gly Pro Pro 
    18395                 18400                 18405             


Ser Thr   Pro Glu Val Ser Ala   Ile Thr Lys Asp Ser   Met Val Val 
    18410                 18415                 18420             


Thr Trp   Ala Arg Pro Val Asp   Asp Gly Gly Thr Glu   Ile Glu Gly 
    18425                 18430                 18435             


Tyr Ile   Leu Glu Lys Arg Asp   Lys Glu Gly Val Arg   Trp Thr Lys 
    18440                 18445                 18450             


Cys Asn   Lys Lys Thr Leu Thr   Asp Leu Arg Leu Arg   Val Thr Gly 
    18455                 18460                 18465             


Leu Thr   Glu Gly His Ser Tyr   Glu Phe Arg Val Ala   Ala Glu Asn 
    18470                 18475                 18480             


Ala Ala   Gly Val Gly Glu Pro   Ser Glu Pro Ser Val   Phe Tyr Arg 
    18485                 18490                 18495             


Ala Cys   Asp Ala Leu Tyr Pro   Pro Gly Pro Pro Ser   Asn Pro Lys 
    18500                 18505                 18510             


Val Thr   Asp Thr Ser Arg Ser   Ser Val Ser Leu Ala   Trp Ser Lys 
    18515                 18520                 18525             


Pro Ile   Tyr Asp Gly Gly Ala   Pro Val Lys Gly Tyr   Val Val Glu 
    18530                 18535                 18540             


Val Lys   Glu Ala Ala Ala Asp   Glu Trp Thr Thr Cys   Thr Pro Pro 
    18545                 18550                 18555             


Thr Gly   Leu Gln Gly Lys Gln   Phe Thr Val Thr Lys   Leu Lys Glu 
    18560                 18565                 18570             


Asn Thr   Glu Tyr Asn Phe Arg   Ile Cys Ala Ile Asn   Ser Glu Gly 
    18575                 18580                 18585             


Val Gly   Glu Pro Ala Thr Leu   Pro Gly Ser Val Val   Ala Gln Glu 
    18590                 18595                 18600             


Arg Ile   Glu Pro Pro Glu Ile   Glu Leu Asp Ala Asp   Leu Arg Lys 
    18605                 18610                 18615             


Val Val   Val Leu Arg Ala Ser   Ala Thr Leu Arg Leu   Phe Val Thr 
    18620                 18625                 18630             


Ile Lys   Gly Arg Pro Glu Pro   Glu Val Lys Trp Glu   Lys Ala Glu 
    18635                 18640                 18645             


Gly Ile   Leu Thr Asp Arg Ala   Gln Ile Glu Val Thr   Ser Ser Phe 
    18650                 18655                 18660             


Thr Met   Leu Val Ile Asp Asn   Val Thr Arg Phe Asp   Ser Gly Arg 
    18665                 18670                 18675             


Tyr Asn   Leu Thr Leu Glu Asn   Asn Ser Gly Ser Lys   Thr Ala Phe 
    18680                 18685                 18690             


Val Asn   Val Arg Val Leu Asp   Ser Pro Ser Ala Pro   Val Asn Leu 
    18695                 18700                 18705             


Thr Ile   Arg Glu Val Lys Lys   Asp Ser Val Thr Leu   Ser Trp Glu 
    18710                 18715                 18720             


Pro Pro   Leu Ile Asp Gly Gly   Ala Lys Ile Thr Asn   Tyr Ile Val 
    18725                 18730                 18735             


Glu Lys   Arg Glu Thr Thr Arg   Lys Ala Tyr Ala Thr   Ile Thr Asn 
    18740                 18745                 18750             


Asn Cys   Thr Lys Thr Thr Phe   Arg Ile Glu Asn Leu   Gln Glu Gly 
    18755                 18760                 18765             


Cys Ser   Tyr Tyr Phe Arg Val   Leu Ala Ser Asn Glu   Tyr Gly Ile 
    18770                 18775                 18780             


Gly Leu   Pro Ala Glu Thr Thr   Glu Pro Val Lys Val   Ser Glu Pro 
    18785                 18790                 18795             


Pro Leu   Pro Pro Gly Arg Val   Thr Leu Val Asp Val   Thr Arg Asn 
    18800                 18805                 18810             


Thr Ala   Thr Ile Lys Trp Glu   Lys Pro Glu Ser Asp   Gly Gly Ser 
    18815                 18820                 18825             


Lys Ile   Thr Gly Tyr Val Val   Glu Met Gln Thr Lys   Gly Ser Glu 
    18830                 18835                 18840             


Lys Trp   Ser Thr Cys Thr Gln   Val Lys Thr Leu Glu   Ala Thr Ile 
    18845                 18850                 18855             


Ser Gly   Leu Thr Ala Gly Glu   Glu Tyr Val Phe Arg   Val Ala Ala 
    18860                 18865                 18870             


Val Asn   Glu Lys Gly Arg Ser   Asp Pro Arg Gln Leu   Gly Val Pro 
    18875                 18880                 18885             


Val Ile   Ala Arg Asp Ile Glu   Ile Lys Pro Ser Val   Glu Leu Pro 
    18890                 18895                 18900             


Phe His   Thr Phe Asn Val Lys   Ala Arg Glu Gln Leu   Lys Ile Asp 
    18905                 18910                 18915             


Val Pro   Phe Lys Gly Arg Pro   Gln Ala Thr Val Asn   Trp Arg Lys 
    18920                 18925                 18930             


Asp Gly   Gln Thr Leu Lys Glu   Thr Thr Arg Val Asn   Val Ser Ser 
    18935                 18940                 18945             


Ser Lys   Thr Val Thr Ser Leu   Ser Ile Lys Glu Ala   Ser Lys Glu 
    18950                 18955                 18960             


Asp Val   Gly Thr Tyr Glu Leu   Cys Val Ser Asn Ser   Ala Gly Ser 
    18965                 18970                 18975             


Ile Thr   Val Pro Ile Thr Ile   Ile Val Leu Asp Arg   Pro Gly Pro 
    18980                 18985                 18990             


Pro Gly   Pro Ile Arg Ile Asp   Glu Val Ser Cys Asp   Ser Ile Thr 
    18995                 19000                 19005             


Ile Ser   Trp Asn Pro Pro Glu   Tyr Asp Gly Gly Cys   Gln Ile Ser 
    19010                 19015                 19020             


Asn Tyr   Ile Val Glu Lys Lys   Glu Thr Thr Ser Thr   Thr Trp His 
    19025                 19030                 19035             


Ile Val   Ser Gln Ala Val Ala   Arg Thr Ser Ile Lys   Ile Val Arg 
    19040                 19045                 19050             


Leu Thr   Thr Gly Ser Glu Tyr   Gln Phe Arg Val Cys   Ala Glu Asn 
    19055                 19060                 19065             


Arg Tyr   Gly Lys Ser Ser Tyr   Ser Glu Ser Ser Ala   Val Val Ala 
    19070                 19075                 19080             


Glu Tyr   Pro Phe Ser Pro Pro   Gly Pro Pro Gly Thr   Pro Lys Val 
    19085                 19090                 19095             


Val His   Ala Thr Lys Ser Thr   Met Leu Val Thr Trp   Gln Val Pro 
    19100                 19105                 19110             


Val Asn   Asp Gly Gly Ser Arg   Val Ile Gly Tyr His   Leu Glu Tyr 
    19115                 19120                 19125             


Lys Glu   Arg Ser Ser Ile Leu   Trp Ser Lys Ala Asn   Lys Ile Leu 
    19130                 19135                 19140             


Ile Ala   Asp Thr Gln Met Lys   Val Ser Gly Leu Asp   Glu Gly Leu 
    19145                 19150                 19155             


Met Tyr   Glu Tyr Arg Val Tyr   Ala Glu Asn Ile Ala   Gly Ile Gly 
    19160                 19165                 19170             


Lys Cys   Ser Lys Ser Cys Glu   Pro Val Pro Ala Arg   Asp Pro Cys 
    19175                 19180                 19185             


Asp Pro   Pro Gly Gln Pro Glu   Val Thr Asn Ile Thr   Arg Lys Ser 
    19190                 19195                 19200             


Val Ser   Leu Lys Trp Ser Lys   Pro His Tyr Asp Gly   Gly Ala Lys 
    19205                 19210                 19215             


Ile Thr   Gly Tyr Ile Val Glu   Arg Arg Glu Leu Pro   Asp Gly Arg 
    19220                 19225                 19230             


Trp Leu   Lys Cys Asn Tyr Thr   Asn Ile Gln Glu Thr   Tyr Phe Glu 
    19235                 19240                 19245             


Val Thr   Glu Leu Thr Glu Asp   Gln Arg Tyr Glu Phe   Arg Val Phe 
    19250                 19255                 19260             


Ala Arg   Asn Ala Ala Asp Ser   Val Ser Glu Pro Ser   Glu Ser Thr 
    19265                 19270                 19275             


Gly Pro   Ile Ile Val Lys Asp   Asp Val Glu Pro Pro   Arg Val Met 
    19280                 19285                 19290             


Met Asp   Val Lys Phe Arg Asp   Val Ile Val Val Lys   Ala Gly Glu 
    19295                 19300                 19305             


Val Leu   Lys Ile Asn Ala Asp   Ile Ala Gly Arg Pro   Leu Pro Val 
    19310                 19315                 19320             


Ile Ser   Trp Ala Lys Asp Gly   Ile Glu Ile Glu Glu   Arg Ala Arg 
    19325                 19330                 19335             


Thr Glu   Ile Ile Ser Thr Asp   Asn His Thr Leu Leu   Thr Val Lys 
    19340                 19345                 19350             


Asp Cys   Ile Arg Arg Asp Thr   Gly Gln Tyr Val Leu   Thr Leu Lys 
    19355                 19360                 19365             


Asn Val   Ala Gly Thr Arg Ser   Val Ala Val Asn Cys   Lys Val Leu 
    19370                 19375                 19380             


Asp Lys   Pro Gly Pro Pro Ala   Gly Pro Leu Glu Ile   Asn Gly Leu 
    19385                 19390                 19395             


Thr Ala   Glu Lys Cys Ser Leu   Ser Trp Gly Arg Pro   Gln Glu Asp 
    19400                 19405                 19410             


Gly Gly   Ala Asp Ile Asp Tyr   Tyr Ile Val Glu Lys   Arg Glu Thr 
    19415                 19420                 19425             


Ser His   Leu Ala Trp Thr Ile   Cys Glu Gly Glu Leu   Gln Met Thr 
    19430                 19435                 19440             


Ser Cys   Lys Val Thr Lys Leu   Leu Lys Gly Asn Glu   Tyr Ile Phe 
    19445                 19450                 19455             


Arg Val   Thr Gly Val Asn Lys   Tyr Gly Val Gly Glu   Pro Leu Glu 
    19460                 19465                 19470             


Ser Val   Ala Ile Lys Ala Leu   Asp Pro Phe Thr Val   Pro Ser Pro 
    19475                 19480                 19485             


Pro Thr   Ser Leu Glu Ile Thr   Ser Val Thr Lys Glu   Ser Met Thr 
    19490                 19495                 19500             


Leu Cys   Trp Ser Arg Pro Glu   Ser Asp Gly Gly Ser   Glu Ile Ser 
    19505                 19510                 19515             


Gly Tyr   Ile Ile Glu Arg Arg   Glu Lys Asn Ser Leu   Arg Trp Val 
    19520                 19525                 19530             


Arg Val   Asn Lys Lys Pro Val   Tyr Asp Leu Arg Val   Lys Ser Thr 
    19535                 19540                 19545             


Gly Leu   Arg Glu Gly Cys Glu   Tyr Glu Tyr Arg Val   Tyr Ala Glu 
    19550                 19555                 19560             


Asn Ala   Ala Gly Leu Ser Leu   Pro Ser Glu Thr Ser   Pro Leu Ile 
    19565                 19570                 19575             


Arg Ala   Glu Asp Pro Val Phe   Leu Pro Ser Pro Pro   Ser Lys Pro 
    19580                 19585                 19590             


Lys Ile   Val Asp Ser Gly Lys   Thr Thr Ile Thr Ile   Ala Trp Val 
    19595                 19600                 19605             


Lys Pro   Leu Phe Asp Gly Gly   Ala Pro Ile Thr Gly   Tyr Thr Val 
    19610                 19615                 19620             


Glu Tyr   Lys Lys Ser Asp Asp   Thr Asp Trp Lys Thr   Ser Ile Gln 
    19625                 19630                 19635             


Ser Leu   Arg Gly Thr Glu Tyr   Thr Ile Ser Gly Leu   Thr Thr Gly 
    19640                 19645                 19650             


Ala Glu   Tyr Val Phe Arg Val   Lys Ser Val Asn Lys   Val Gly Ala 
    19655                 19660                 19665             


Ser Asp   Pro Ser Asp Ser Ser   Asp Pro Gln Ile Ala   Lys Glu Arg 
    19670                 19675                 19680             


Glu Glu   Glu Pro Leu Phe Asp   Ile Asp Ser Glu Met   Arg Lys Thr 
    19685                 19690                 19695             


Leu Ile   Val Lys Ala Gly Ala   Ser Phe Thr Met Thr   Val Pro Phe 
    19700                 19705                 19710             


Arg Gly   Arg Pro Val Pro Asn   Val Leu Trp Ser Lys   Pro Asp Thr 
    19715                 19720                 19725             


Asp Leu   Arg Thr Arg Ala Tyr   Val Asp Thr Thr Asp   Ser Arg Thr 
    19730                 19735                 19740             


Ser Leu   Thr Ile Glu Asn Ala   Asn Arg Asn Asp Ser   Gly Lys Tyr 
    19745                 19750                 19755             


Thr Leu   Thr Ile Gln Asn Val   Leu Ser Ala Ala Ser   Leu Thr Leu 
    19760                 19765                 19770             


Val Val   Lys Val Leu Asp Thr   Pro Gly Pro Pro Thr   Asn Ile Thr 
    19775                 19780                 19785             


Val Gln   Asp Val Thr Lys Glu   Ser Ala Val Leu Ser   Trp Asp Val 
    19790                 19795                 19800             


Pro Glu   Asn Asp Gly Gly Ala   Pro Val Lys Asn Tyr   His Ile Glu 
    19805                 19810                 19815             


Lys Arg   Glu Ala Ser Lys Lys   Ala Trp Val Ser Val   Thr Asn Asn 
    19820                 19825                 19830             


Cys Asn   Arg Leu Ser Tyr Lys   Val Thr Asn Leu Gln   Glu Gly Ala 
    19835                 19840                 19845             


Ile Tyr   Tyr Phe Arg Val Ser   Gly Glu Asn Glu Phe   Gly Val Gly 
    19850                 19855                 19860             


Ile Pro   Ala Glu Thr Lys Glu   Gly Val Lys Ile Thr   Glu Lys Pro 
    19865                 19870                 19875             


Ser Pro   Pro Glu Lys Leu Gly   Val Thr Ser Ile Ser   Lys Asp Ser 
    19880                 19885                 19890             


Val Ser   Leu Thr Trp Leu Lys   Pro Glu His Asp Gly   Gly Ser Arg 
    19895                 19900                 19905             


Ile Val   His Tyr Val Val Glu   Ala Leu Glu Lys Gly   Gln Lys Asn 
    19910                 19915                 19920             


Trp Val   Lys Cys Ala Val Ala   Lys Ser Thr His His   Val Val Ser 
    19925                 19930                 19935             


Gly Leu   Arg Glu Asn Ser Glu   Tyr Phe Phe Arg Val   Phe Ala Glu 
    19940                 19945                 19950             


Asn Gln   Ala Gly Leu Ser Asp   Pro Arg Glu Leu Leu   Leu Pro Val 
    19955                 19960                 19965             


Leu Ile   Lys Glu Gln Leu Glu   Pro Pro Glu Ile Asp   Met Lys Asn 
    19970                 19975                 19980             


Phe Pro   Ser His Thr Val Tyr   Val Arg Ala Gly Ser   Asn Leu Lys 
    19985                 19990                 19995             


Val Asp   Ile Pro Ile Ser Gly   Lys Pro Leu Pro Lys   Val Thr Leu 
    20000                 20005                 20010             


Ser Arg   Asp Gly Val Pro Leu   Lys Ala Thr Met Arg   Phe Asn Thr 
    20015                 20020                 20025             


Glu Ile   Thr Ala Glu Asn Leu   Thr Ile Asn Leu Lys   Glu Ser Val 
    20030                 20035                 20040             


Thr Ala   Asp Ala Gly Arg Tyr   Glu Ile Thr Ala Ala   Asn Ser Ser 
    20045                 20050                 20055             


Gly Thr   Thr Lys Ala Phe Ile   Asn Ile Val Val Leu   Asp Arg Pro 
    20060                 20065                 20070             


Gly Pro   Pro Thr Gly Pro Val   Val Ile Ser Asp Ile   Thr Glu Glu 
    20075                 20080                 20085             


Ser Val   Thr Leu Lys Trp Glu   Pro Pro Lys Tyr Asp   Gly Gly Ser 
    20090                 20095                 20100             


Gln Val   Thr Asn Tyr Ile Leu   Leu Lys Arg Glu Thr   Ser Thr Ala 
    20105                 20110                 20115             


Val Trp   Thr Glu Val Ser Ala   Thr Val Ala Arg Thr   Met Met Lys 
    20120                 20125                 20130             


Val Met   Lys Leu Thr Thr Gly   Glu Glu Tyr Gln Phe   Arg Ile Lys 
    20135                 20140                 20145             


Ala Glu   Asn Arg Phe Gly Ile   Ser Asp His Ile Asp   Ser Ala Cys 
    20150                 20155                 20160             


Val Thr   Val Lys Leu Pro Tyr   Thr Thr Pro Gly Pro   Pro Ser Thr 
    20165                 20170                 20175             


Pro Trp   Val Thr Asn Val Thr   Arg Glu Ser Ile Thr   Val Gly Trp 
    20180                 20185                 20190             


His Glu   Pro Val Ser Asn Gly   Gly Ser Ala Val Val   Gly Tyr His 
    20195                 20200                 20205             


Leu Glu   Met Lys Asp Arg Asn   Ser Ile Leu Trp Gln   Lys Ala Asn 
    20210                 20215                 20220             


Lys Leu   Val Ile Arg Thr Thr   His Phe Lys Val Thr   Thr Ile Ser 
    20225                 20230                 20235             


Ala Gly   Leu Ile Tyr Glu Phe   Arg Val Tyr Ala Glu   Asn Ala Ala 
    20240                 20245                 20250             


Gly Val   Gly Lys Pro Ser His   Pro Ser Glu Pro Val   Leu Ala Ile 
    20255                 20260                 20265             


Asp Ala   Cys Glu Pro Pro Arg   Asn Val Arg Ile Thr   Asp Ile Ser 
    20270                 20275                 20280             


Lys Asn   Ser Val Ser Leu Ser   Trp Gln Gln Pro Ala   Phe Asp Gly 
    20285                 20290                 20295             


Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu Arg Arg   Asp Leu Pro 
    20300                 20305                 20310             


Asp Gly   Arg Trp Thr Lys Ala   Ser Phe Thr Asn Val   Thr Glu Thr 
    20315                 20320                 20325             


Gln Phe   Ile Ile Ser Gly Leu   Thr Gln Asn Ser Gln   Tyr Glu Phe 
    20330                 20335                 20340             


Arg Val   Phe Ala Arg Asn Ala   Val Gly Ser Ile Ser   Asn Pro Ser 
    20345                 20350                 20355             


Glu Val   Val Gly Pro Ile Thr   Cys Ile Asp Ser Tyr   Gly Gly Pro 
    20360                 20365                 20370             


Val Ile   Asp Leu Pro Leu Glu   Tyr Thr Glu Val Val   Lys Tyr Arg 
    20375                 20380                 20385             


Ala Gly   Thr Ser Val Lys Leu   Arg Ala Gly Ile Ser   Gly Lys Pro 
    20390                 20395                 20400             


Ala Pro   Thr Ile Glu Trp Tyr   Lys Asp Asp Lys Glu   Leu Gln Thr 
    20405                 20410                 20415             


Asn Ala   Leu Val Cys Val Glu   Asn Thr Thr Asp Leu   Ala Ser Ile 
    20420                 20425                 20430             


Leu Ile   Lys Asp Ala Asp Arg   Leu Asn Ser Gly Cys   Tyr Glu Leu 
    20435                 20440                 20445             


Lys Leu   Arg Asn Ala Met Gly   Ser Ala Ser Ala Thr   Ile Arg Val 
    20450                 20455                 20460             


Gln Ile   Leu Asp Lys Pro Gly   Pro Pro Gly Gly Pro   Ile Glu Phe 
    20465                 20470                 20475             


Lys Thr   Val Thr Ala Glu Lys   Ile Thr Leu Leu Trp   Arg Pro Pro 
    20480                 20485                 20490             


Ala Asp   Asp Gly Gly Ala Lys   Ile Thr His Tyr Ile   Val Glu Lys 
    20495                 20500                 20505             


Arg Glu   Thr Ser Arg Val Val   Trp Ser Met Val Ser   Glu His Leu 
    20510                 20515                 20520             


Glu Glu   Cys Ile Ile Thr Thr   Thr Lys Ile Ile Lys   Gly Asn Glu 
    20525                 20530                 20535             


Tyr Ile   Phe Arg Val Arg Ala   Val Asn Lys Tyr Gly   Ile Gly Glu 
    20540                 20545                 20550             


Pro Leu   Glu Ser Asp Ser Val   Val Ala Lys Asn Ala   Phe Val Thr 
    20555                 20560                 20565             


Pro Gly   Pro Pro Gly Ile Pro   Glu Val Thr Lys Ile   Thr Lys Asn 
    20570                 20575                 20580             


Ser Met   Thr Val Val Trp Ser   Arg Pro Ile Ala Asp   Gly Gly Ser 
    20585                 20590                 20595             


Asp Ile   Ser Gly Tyr Phe Leu   Glu Lys Arg Asp Lys   Lys Ser Leu 
    20600                 20605                 20610             


Gly Trp   Phe Lys Val Leu Lys   Glu Thr Ile Arg Asp   Thr Arg Gln 
    20615                 20620                 20625             


Lys Val   Thr Gly Leu Thr Glu   Asn Ser Asp Tyr Gln   Tyr Arg Val 
    20630                 20635                 20640             


Cys Ala   Val Asn Ala Ala Gly   Gln Gly Pro Phe Ser   Glu Pro Ser 
    20645                 20650                 20655             


Glu Phe   Tyr Lys Ala Ala Asp   Pro Ile Asp Pro Pro   Gly Pro Pro 
    20660                 20665                 20670             


Ala Lys   Ile Arg Ile Ala Asp   Ser Thr Lys Ser Ser   Ile Thr Leu 
    20675                 20680                 20685             


Gly Trp   Ser Lys Pro Val Tyr   Asp Gly Gly Ser Ala   Val Thr Gly 
    20690                 20695                 20700             


Tyr Val   Val Glu Ile Arg Gln   Gly Glu Glu Glu Glu   Trp Thr Thr 
    20705                 20710                 20715             


Val Ser   Thr Lys Gly Glu Val   Arg Thr Thr Glu Tyr   Val Val Ser 
    20720                 20725                 20730             


Asn Leu   Lys Pro Gly Val Asn   Tyr Tyr Phe Arg Val   Ser Ala Val 
    20735                 20740                 20745             


Asn Cys   Ala Gly Gln Gly Glu   Pro Ile Glu Met Asn   Glu Pro Val 
    20750                 20755                 20760             


Gln Ala   Lys Asp Ile Leu Glu   Ala Pro Glu Ile Asp   Leu Asp Val 
    20765                 20770                 20775             


Ala Leu   Arg Thr Ser Val Ile   Ala Lys Ala Gly Glu   Asp Val Gln 
    20780                 20785                 20790             


Val Leu   Ile Pro Phe Lys Gly   Arg Pro Pro Pro Thr   Val Thr Trp 
    20795                 20800                 20805             


Arg Lys   Asp Glu Lys Asn Leu   Gly Ser Asp Ala Arg   Tyr Ser Ile 
    20810                 20815                 20820             


Glu Asn   Thr Asp Ser Ser Ser   Leu Leu Thr Ile Pro   Gln Val Thr 
    20825                 20830                 20835             


Arg Asn   Asp Thr Gly Lys Tyr   Ile Leu Thr Ile Glu   Asn Gly Val 
    20840                 20845                 20850             


Gly Glu   Pro Lys Ser Ser Thr   Val Ser Val Lys Val   Leu Asp Thr 
    20855                 20860                 20865             


Pro Ala   Ala Cys Gln Lys Leu   Gln Val Lys His Val   Ser Arg Gly 
    20870                 20875                 20880             


Thr Val   Thr Leu Leu Trp Asp   Pro Pro Leu Ile Asp   Gly Gly Ser 
    20885                 20890                 20895             


Pro Ile   Ile Asn Tyr Val Ile   Glu Lys Arg Asp Ala   Thr Lys Arg 
    20900                 20905                 20910             


Thr Trp   Ser Val Val Ser His   Lys Cys Ser Ser Thr   Ser Phe Lys 
    20915                 20920                 20925             


Leu Ile   Asp Leu Ser Glu Lys   Thr Pro Phe Phe Phe   Arg Val Leu 
    20930                 20935                 20940             


Ala Glu   Asn Glu Ile Gly Ile   Gly Glu Pro Cys Glu   Thr Thr Glu 
    20945                 20950                 20955             


Pro Val   Lys Ala Ala Glu Val   Pro Ala Pro Ile Arg   Asp Leu Ser 
    20960                 20965                 20970             


Met Lys   Asp Ser Thr Lys Thr   Ser Val Ile Leu Ser   Trp Thr Lys 
    20975                 20980                 20985             


Pro Asp   Phe Asp Gly Gly Ser   Val Ile Thr Glu Tyr   Val Val Glu 
    20990                 20995                 21000             


Arg Lys   Gly Lys Gly Glu Gln   Thr Trp Ser His Ala   Gly Ile Ser 
    21005                 21010                 21015             


Lys Thr   Cys Glu Ile Glu Val   Ser Gln Leu Lys Glu   Gln Ser Val 
    21020                 21025                 21030             


Leu Glu   Phe Arg Val Phe Ala   Lys Asn Glu Lys Gly   Leu Ser Asp 
    21035                 21040                 21045             


Pro Val   Thr Ile Gly Pro Ile   Thr Val Lys Glu Leu   Ile Ile Thr 
    21050                 21055                 21060             


Pro Glu   Val Asp Leu Ser Asp   Ile Pro Gly Ala Gln   Val Thr Val 
    21065                 21070                 21075             


Arg Ile   Gly His Asn Val His   Leu Glu Leu Pro Tyr   Lys Gly Lys 
    21080                 21085                 21090             


Pro Lys   Pro Ser Ile Ser Trp   Leu Lys Asp Gly Leu   Pro Leu Lys 
    21095                 21100                 21105             


Glu Ser   Glu Phe Val Arg Phe   Ser Lys Thr Glu Asn   Lys Ile Thr 
    21110                 21115                 21120             


Leu Ser   Ile Lys Asn Ala Lys   Lys Glu His Gly Gly   Lys Tyr Thr 
    21125                 21130                 21135             


Val Ile   Leu Asp Asn Ala Val   Cys Arg Ile Ala Val   Pro Ile Thr 
    21140                 21145                 21150             


Val Ile   Thr Leu Gly Pro Pro   Ser Lys Pro Lys Gly   Pro Ile Arg 
    21155                 21160                 21165             


Phe Asp   Glu Ile Lys Ala Asp   Ser Val Ile Leu Ser   Trp Asp Val 
    21170                 21175                 21180             


Pro Glu   Asp Asn Gly Gly Gly   Glu Ile Thr Cys Tyr   Ser Ile Glu 
    21185                 21190                 21195             


Lys Arg   Glu Thr Ser Gln Thr   Asn Trp Lys Met Val   Cys Ser Ser 
    21200                 21205                 21210             


Val Ala   Arg Thr Thr Phe Lys   Val Pro Asn Leu Val   Lys Asp Ala 
    21215                 21220                 21225             


Glu Tyr   Gln Phe Arg Val Arg   Ala Glu Asn Arg Tyr   Gly Val Ser 
    21230                 21235                 21240             


Gln Pro   Leu Val Ser Ser Ile   Ile Val Ala Lys His   Gln Phe Arg 
    21245                 21250                 21255             


Ile Pro   Gly Pro Pro Gly Lys   Pro Val Ile Tyr Asn   Val Thr Ser 
    21260                 21265                 21270             


Asp Gly   Met Ser Leu Thr Trp   Asp Ala Pro Val Tyr   Asp Gly Gly 
    21275                 21280                 21285             


Ser Glu   Val Thr Gly Phe His   Val Glu Lys Lys Glu   Arg Asn Ser 
    21290                 21295                 21300             


Ile Leu   Trp Gln Lys Val Asn   Thr Ser Pro Ile Ser   Gly Arg Glu 
    21305                 21310                 21315             


Tyr Arg   Ala Thr Gly Leu Val   Glu Gly Leu Asp Tyr   Gln Phe Arg 
    21320                 21325                 21330             


Val Tyr   Ala Glu Asn Ser Ala   Gly Leu Ser Ser Pro   Ser Asp Pro 
    21335                 21340                 21345             


Ser Lys   Phe Thr Leu Ala Val   Ser Pro Val Asp Pro   Pro Gly Thr 
    21350                 21355                 21360             


Pro Asp   Tyr Ile Asp Val Thr   Arg Glu Thr Ile Thr   Leu Lys Trp 
    21365                 21370                 21375             


Asn Pro   Pro Leu Arg Asp Gly   Gly Ser Lys Ile Val   Gly Tyr Ser 
    21380                 21385                 21390             


Ile Glu   Lys Arg Gln Gly Asn   Glu Arg Trp Val Arg   Cys Asn Phe 
    21395                 21400                 21405             


Thr Asp   Val Ser Glu Cys Gln   Tyr Thr Val Thr Gly   Leu Ser Pro 
    21410                 21415                 21420             


Gly Asp   Arg Tyr Glu Phe Arg   Ile Ile Ala Arg Asn   Ala Val Gly 
    21425                 21430                 21435             


Thr Ile   Ser Pro Pro Ser Gln   Ser Ser Gly Ile Ile   Met Thr Arg 
    21440                 21445                 21450             


Asp Glu   Asn Val Pro Pro Ile   Val Glu Phe Gly Pro   Glu Tyr Phe 
    21455                 21460                 21465             


Asp Gly   Leu Ile Ile Lys Ser   Gly Glu Ser Leu Arg   Ile Lys Ala 
    21470                 21475                 21480             


Leu Val   Gln Gly Arg Pro Val   Pro Arg Val Thr Trp   Phe Lys Asp 
    21485                 21490                 21495             


Gly Val   Glu Ile Glu Lys Arg   Met Asn Met Glu Ile   Thr Asp Val 
    21500                 21505                 21510             


Leu Gly   Ser Thr Ser Leu Phe   Val Arg Asp Ala Thr   Arg Asp His 
    21515                 21520                 21525             


Arg Gly   Val Tyr Thr Val Glu   Ala Lys Asn Ala Ser   Gly Ser Ala 
    21530                 21535                 21540             


Lys Ala   Glu Ile Lys Val Lys   Val Gln Asp Thr Pro   Gly Lys Val 
    21545                 21550                 21555             


Val Gly   Pro Ile Arg Phe Thr   Asn Ile Thr Gly Glu   Lys Met Thr 
    21560                 21565                 21570             


Leu Trp   Trp Asp Ala Pro Leu   Asn Asp Gly Cys Ala   Pro Ile Thr 
    21575                 21580                 21585             


His Tyr   Ile Ile Glu Lys Arg   Glu Thr Ser Arg Leu   Ala Trp Ala 
    21590                 21595                 21600             


Leu Ile   Glu Asp Lys Cys Glu   Ala Gln Ser Tyr Thr   Ala Ile Lys 
    21605                 21610                 21615             


Leu Ile   Asn Gly Asn Glu Tyr   Gln Phe Arg Val Ser   Ala Val Asn 
    21620                 21625                 21630             


Lys Phe   Gly Val Gly Arg Pro   Leu Asp Ser Asp Pro   Val Val Ala 
    21635                 21640                 21645             


Gln Ile   Gln Tyr Thr Val Pro   Asp Ala Pro Gly Ile   Pro Glu Pro 
    21650                 21655                 21660             


Ser Asn   Ile Thr Gly Asn Ser   Ile Thr Leu Thr Trp   Ala Arg Pro 
    21665                 21670                 21675             


Glu Ser   Asp Gly Gly Ser Glu   Ile Gln Gln Tyr Ile   Leu Glu Arg 
    21680                 21685                 21690             


Arg Glu   Lys Lys Ser Thr Arg   Trp Val Lys Val Ile   Ser Lys Arg 
    21695                 21700                 21705             


Pro Ile   Ser Glu Thr Arg Phe   Lys Val Thr Gly Leu   Thr Glu Gly 
    21710                 21715                 21720             


Asn Glu   Tyr Glu Phe His Val   Met Ala Glu Asn Ala   Ala Gly Val 
    21725                 21730                 21735             


Gly Pro   Ala Ser Gly Ile Ser   Arg Leu Ile Lys Cys   Arg Glu Pro 
    21740                 21745                 21750             


Val Asn   Pro Pro Gly Pro Pro   Thr Val Val Lys Val   Thr Asp Thr 
    21755                 21760                 21765             


Ser Lys   Thr Thr Val Ser Leu   Glu Trp Ser Lys Pro   Val Phe Asp 
    21770                 21775                 21780             


Gly Gly   Met Glu Ile Ile Gly   Tyr Ile Ile Glu Met   Cys Lys Ala 
    21785                 21790                 21795             


Asp Leu   Gly Asp Trp His Lys   Val Asn Ala Glu Ala   Cys Val Lys 
    21800                 21805                 21810             


Thr Arg   Tyr Thr Val Thr Asp   Leu Gln Ala Gly Glu   Glu Tyr Lys 
    21815                 21820                 21825             


Phe Arg   Val Ser Ala Ile Asn   Gly Ala Gly Lys Gly   Asp Ser Cys 
    21830                 21835                 21840             


Glu Val   Thr Gly Thr Ile Lys   Ala Val Asp Arg Leu   Thr Ala Pro 
    21845                 21850                 21855             


Glu Leu   Asp Ile Asp Ala Asn   Phe Lys Gln Thr His   Val Val Arg 
    21860                 21865                 21870             


Ala Gly   Ala Ser Ile Arg Leu   Phe Ile Ala Tyr Gln   Gly Arg Pro 
    21875                 21880                 21885             


Thr Pro   Thr Ala Val Trp Ser   Lys Pro Asp Ser Asn   Leu Ser Leu 
    21890                 21895                 21900             


Arg Ala   Asp Ile His Thr Thr   Asp Ser Phe Ser Thr   Leu Thr Val 
    21905                 21910                 21915             


Glu Asn   Cys Asn Arg Asn Asp   Ala Gly Lys Tyr Thr   Leu Thr Val 
    21920                 21925                 21930             


Glu Asn   Asn Ser Gly Ser Lys   Ser Ile Thr Phe Thr   Val Lys Val 
    21935                 21940                 21945             


Leu Asp   Thr Pro Gly Pro Pro   Gly Pro Ile Thr Phe   Lys Asp Val 
    21950                 21955                 21960             


Thr Arg   Gly Ser Ala Thr Leu   Met Trp Asp Ala Pro   Leu Leu Asp 
    21965                 21970                 21975             


Gly Gly   Ala Arg Ile His His   Tyr Val Val Glu Lys   Arg Glu Ala 
    21980                 21985                 21990             


Ser Arg   Arg Ser Trp Gln Val   Ile Ser Glu Lys Cys   Thr Arg Gln 
    21995                 22000                 22005             


Ile Phe   Lys Val Asn Asp Leu   Ala Glu Gly Val Pro   Tyr Tyr Phe 
    22010                 22015                 22020             


Arg Val   Ser Ala Val Asn Glu   Tyr Gly Val Gly Glu   Pro Tyr Glu 
    22025                 22030                 22035             


Met Pro   Glu Pro Ile Val Ala   Thr Glu Gln Pro Ala   Pro Pro Arg 
    22040                 22045                 22050             


Arg Leu   Asp Val Val Asp Thr   Ser Lys Ser Ser Ala   Val Leu Ala 
    22055                 22060                 22065             


Trp Leu   Lys Pro Asp His Asp   Gly Gly Ser Arg Ile   Thr Gly Tyr 
    22070                 22075                 22080             


Leu Leu   Glu Met Arg Gln Lys   Gly Ser Asp Phe Trp   Val Glu Ala 
    22085                 22090                 22095             


Gly His   Thr Lys Gln Leu Thr   Phe Thr Val Glu Arg   Leu Val Glu 
    22100                 22105                 22110             


Lys Thr   Glu Tyr Glu Phe Arg   Val Lys Ala Lys Asn   Asp Ala Gly 
    22115                 22120                 22125             


Tyr Ser   Glu Pro Arg Glu Ala   Phe Ser Ser Val Ile   Ile Lys Glu 
    22130                 22135                 22140             


Pro Gln   Ile Glu Pro Thr Ala   Asp Leu Thr Gly Ile   Thr Asn Gln 
    22145                 22150                 22155             


Leu Ile   Thr Cys Lys Ala Gly   Ser Pro Phe Thr Ile   Asp Val Pro 
    22160                 22165                 22170             


Ile Ser   Gly Arg Pro Ala Pro   Lys Val Thr Trp Lys   Leu Glu Glu 
    22175                 22180                 22185             


Met Arg   Leu Lys Glu Thr Asp   Arg Val Ser Ile Thr   Thr Thr Lys 
    22190                 22195                 22200             


Asp Arg   Thr Thr Leu Thr Val   Lys Asp Ser Met Arg   Gly Asp Ser 
    22205                 22210                 22215             


Gly Arg   Tyr Phe Leu Thr Leu   Glu Asn Thr Ala Gly   Val Lys Thr 
    22220                 22225                 22230             


Phe Ser   Val Thr Val Val Val   Ile Gly Arg Pro Gly   Pro Val Thr 
    22235                 22240                 22245             


Gly Pro   Ile Glu Val Ser Ser   Val Ser Ala Glu Ser   Cys Val Leu 
    22250                 22255                 22260             


Ser Trp   Gly Glu Pro Lys Asp   Gly Gly Gly Thr Glu   Ile Thr Asn 
    22265                 22270                 22275             


Tyr Ile   Val Glu Lys Arg Glu   Ser Gly Thr Thr Ala   Trp Gln Leu 
    22280                 22285                 22290             


Val Asn   Ser Ser Val Lys Arg   Thr Gln Ile Lys Val   Thr His Leu 
    22295                 22300                 22305             


Thr Lys   Tyr Met Glu Tyr Ser   Phe Arg Val Ser Ser   Glu Asn Arg 
    22310                 22315                 22320             


Phe Gly   Val Ser Lys Pro Leu   Glu Ser Ala Pro Ile   Ile Ala Glu 
    22325                 22330                 22335             


His Pro   Phe Val Pro Pro Ser   Ala Pro Thr Arg Pro   Glu Val Tyr 
    22340                 22345                 22350             


His Val   Ser Ala Asn Ala Met   Ser Ile Arg Trp Glu   Glu Pro Tyr 
    22355                 22360                 22365             


His Asp   Gly Gly Ser Lys Ile   Ile Gly Tyr Trp Val   Glu Lys Lys 
    22370                 22375                 22380             


Glu Arg   Asn Thr Ile Leu Trp   Val Lys Glu Asn Lys   Val Pro Cys 
    22385                 22390                 22395             


Leu Glu   Cys Asn Tyr Lys Val   Thr Gly Leu Val Glu   Gly Leu Glu 
    22400                 22405                 22410             


Tyr Gln   Phe Arg Thr Tyr Ala   Leu Asn Ala Ala Gly   Val Ser Lys 
    22415                 22420                 22425             


Ala Ser   Glu Ala Ser Arg Pro   Ile Met Ala Gln Asn   Pro Val Asp 
    22430                 22435                 22440             


Ala Pro   Gly Arg Pro Glu Val   Thr Asp Val Thr Arg   Ser Thr Val 
    22445                 22450                 22455             


Ser Leu   Ile Trp Ser Ala Pro   Ala Tyr Asp Gly Gly   Ser Lys Val 
    22460                 22465                 22470             


Val Gly   Tyr Ile Ile Glu Arg   Lys Pro Val Ser Glu   Val Gly Asp 
    22475                 22480                 22485             


Gly Arg   Trp Leu Lys Cys Asn   Tyr Thr Ile Val Ser   Asp Asn Phe 
    22490                 22495                 22500             


Phe Thr   Val Thr Ala Leu Ser   Glu Gly Asp Thr Tyr   Glu Phe Arg 
    22505                 22510                 22515             


Val Leu   Ala Lys Asn Ala Ala   Gly Val Ile Ser Lys   Gly Ser Glu 
    22520                 22525                 22530             


Ser Thr   Gly Pro Val Thr Cys   Arg Asp Glu Tyr Ala   Pro Pro Lys 
    22535                 22540                 22545             


Ala Glu   Leu Asp Ala Arg Leu   His Gly Asp Leu Val   Thr Ile Arg 
    22550                 22555                 22560             


Ala Gly   Ser Asp Leu Val Leu   Asp Ala Ala Val Gly   Gly Lys Pro 
    22565                 22570                 22575             


Glu Pro   Lys Ile Ile Trp Thr   Lys Gly Asp Lys Glu   Leu Asp Leu 
    22580                 22585                 22590             


Cys Glu   Lys Val Ser Leu Gln   Tyr Thr Gly Lys Arg   Ala Thr Ala 
    22595                 22600                 22605             


Val Ile   Lys Phe Cys Asp Arg   Ser Asp Ser Gly Lys   Tyr Thr Leu 
    22610                 22615                 22620             


Thr Val   Lys Asn Ala Ser Gly   Thr Lys Ala Val Ser   Val Met Val 
    22625                 22630                 22635             


Lys Val   Leu Asp Ser Pro Gly   Pro Cys Gly Lys Leu   Thr Val Ser 
    22640                 22645                 22650             


Arg Val   Thr Gln Glu Lys Cys   Thr Leu Ala Trp Ser   Leu Pro Gln 
    22655                 22660                 22665             


Glu Asp   Gly Gly Ala Glu Ile   Thr His Tyr Ile Val   Glu Arg Arg 
    22670                 22675                 22680             


Glu Thr   Ser Arg Leu Asn Trp   Val Ile Val Glu Gly   Glu Cys Pro 
    22685                 22690                 22695             


Thr Leu   Ser Tyr Val Val Thr   Arg Leu Ile Lys Asn   Asn Glu Tyr 
    22700                 22705                 22710             


Ile Phe   Arg Val Arg Ala Val   Asn Lys Tyr Gly Pro   Gly Val Pro 
    22715                 22720                 22725             


Val Glu   Ser Glu Pro Ile Val   Ala Arg Asn Ser Phe   Thr Ile Pro 
    22730                 22735                 22740             


Ser Pro   Pro Gly Ile Pro Glu   Glu Val Gly Thr Gly   Lys Glu His 
    22745                 22750                 22755             


Ile Ile   Ile Gln Trp Thr Lys   Pro Glu Ser Asp Gly   Gly Asn Glu 
    22760                 22765                 22770             


Ile Ser   Asn Tyr Leu Val Asp   Lys Arg Glu Lys Lys   Ser Leu Arg 
    22775                 22780                 22785             


Trp Thr   Arg Val Asn Lys Asp   Tyr Val Val Tyr Asp   Thr Arg Leu 
    22790                 22795                 22800             


Lys Val   Thr Ser Leu Met Glu   Gly Cys Asp Tyr Gln   Phe Arg Val 
    22805                 22810                 22815             


Thr Ala   Val Asn Ala Ala Gly   Asn Ser Glu Pro Ser   Glu Ala Ser 
    22820                 22825                 22830             


Asn Phe   Ile Ser Cys Arg Glu   Pro Ser Tyr Thr Pro   Gly Pro Pro 
    22835                 22840                 22845             


Ser Ala   Pro Arg Val Val Asp   Thr Thr Lys His Ser   Ile Ser Leu 
    22850                 22855                 22860             


Ala Trp   Thr Lys Pro Met Tyr   Asp Gly Gly Thr Asp   Ile Val Gly 
    22865                 22870                 22875             


Tyr Val   Leu Glu Met Gln Glu   Lys Asp Thr Asp Gln   Trp Tyr Arg 
    22880                 22885                 22890             


Val His   Thr Asn Ala Thr Ile   Arg Asn Thr Glu Phe   Thr Val Pro 
    22895                 22900                 22905             


Asp Leu   Lys Met Gly Gln Lys   Tyr Ser Phe Arg Val   Ala Ala Val 
    22910                 22915                 22920             


Asn Val   Lys Gly Met Ser Glu   Tyr Ser Glu Ser Ile   Ala Glu Ile 
    22925                 22930                 22935             


Glu Pro   Val Glu Arg Ile Glu   Ile Pro Asp Leu Glu   Leu Ala Asp 
    22940                 22945                 22950             


Asp Leu   Lys Lys Thr Val Thr   Ile Arg Ala Gly Ala   Ser Leu Arg 
    22955                 22960                 22965             


Leu Met   Val Ser Val Ser Gly   Arg Pro Pro Pro Val   Ile Thr Trp 
    22970                 22975                 22980             


Ser Lys   Gln Gly Ile Asp Leu   Ala Ser Arg Ala Ile   Ile Asp Thr 
    22985                 22990                 22995             


Thr Glu   Ser Tyr Ser Leu Leu   Ile Val Asp Lys Val   Asn Arg Tyr 
    23000                 23005                 23010             


Asp Ala   Gly Lys Tyr Thr Ile   Glu Ala Glu Asn Gln   Ser Gly Lys 
    23015                 23020                 23025             


Lys Ser   Ala Thr Val Leu Val   Lys Val Tyr Asp Thr   Pro Gly Pro 
    23030                 23035                 23040             


Cys Pro   Ser Val Lys Val Lys   Glu Val Ser Arg Asp   Ser Val Thr 
    23045                 23050                 23055             


Ile Thr   Trp Glu Ile Pro Thr   Ile Asp Gly Gly Ala   Pro Val Asn 
    23060                 23065                 23070             


Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Ala Met Arg   Ala Phe Lys 
    23075                 23080                 23085             


Thr Val   Thr Thr Lys Cys Ser   Lys Thr Leu Tyr Arg   Ile Ser Gly 
    23090                 23095                 23100             


Leu Val   Glu Gly Thr Met Tyr   Tyr Phe Arg Val Leu   Pro Glu Asn 
    23105                 23110                 23115             


Ile Tyr   Gly Ile Gly Glu Pro   Cys Glu Thr Ser Asp   Ala Val Leu 
    23120                 23125                 23130             


Val Ser   Glu Val Pro Leu Val   Pro Ala Lys Leu Glu   Val Val Asp 
    23135                 23140                 23145             


Val Thr   Lys Ser Thr Val Thr   Leu Ala Trp Glu Lys   Pro Leu Tyr 
    23150                 23155                 23160             


Asp Gly   Gly Ser Arg Leu Thr   Gly Tyr Val Leu Glu   Ala Cys Lys 
    23165                 23170                 23175             


Ala Gly   Thr Glu Arg Trp Met   Lys Val Val Thr Leu   Lys Pro Thr 
    23180                 23185                 23190             


Val Leu   Glu His Thr Val Thr   Ser Leu Asn Glu Gly   Glu Gln Tyr 
    23195                 23200                 23205             


Leu Phe   Arg Ile Arg Ala Gln   Asn Glu Lys Gly Val   Ser Glu Pro 
    23210                 23215                 23220             


Arg Glu   Thr Val Thr Ala Val   Thr Val Gln Asp Leu   Arg Val Leu 
    23225                 23230                 23235             


Pro Thr   Ile Asp Leu Ser Thr   Met Pro Gln Lys Thr   Ile His Val 
    23240                 23245                 23250             


Pro Ala   Gly Arg Pro Val Glu   Leu Val Ile Pro Ile   Ala Gly Arg 
    23255                 23260                 23265             


Pro Pro   Pro Ala Ala Ser Trp   Phe Phe Ala Gly Ser   Lys Leu Arg 
    23270                 23275                 23280             


Glu Ser   Glu Arg Val Thr Val   Glu Thr His Thr Lys   Val Ala Lys 
    23285                 23290                 23295             


Leu Thr   Ile Arg Glu Thr Thr   Ile Arg Asp Thr Gly   Glu Tyr Thr 
    23300                 23305                 23310             


Leu Glu   Leu Lys Asn Val Thr   Gly Thr Thr Ser Glu   Thr Ile Lys 
    23315                 23320                 23325             


Val Ile   Ile Leu Asp Lys Pro   Gly Pro Pro Thr Gly   Pro Ile Lys 
    23330                 23335                 23340             


Ile Asp   Glu Ile Asp Ala Thr   Ser Ile Thr Ile Ser   Trp Glu Pro 
    23345                 23350                 23355             


Pro Glu   Leu Asp Gly Gly Ala   Pro Leu Ser Gly Tyr   Val Val Glu 
    23360                 23365                 23370             


Gln Arg   Asp Ala His Arg Pro   Gly Trp Leu Pro Val   Ser Glu Ser 
    23375                 23380                 23385             


Val Thr   Arg Ser Thr Phe Lys   Phe Thr Arg Leu Thr   Glu Gly Asn 
    23390                 23395                 23400             


Glu Tyr   Val Phe Arg Val Ala   Ala Thr Asn Arg Phe   Gly Ile Gly 
    23405                 23410                 23415             


Ser Tyr   Leu Gln Ser Glu Val   Ile Glu Cys Arg Ser   Ser Ile Arg 
    23420                 23425                 23430             


Ile Pro   Gly Pro Pro Glu Thr   Leu Gln Ile Phe Asp   Val Ser Arg 
    23435                 23440                 23445             


Asp Gly   Met Thr Leu Thr Trp   Tyr Pro Pro Glu Asp   Asp Gly Gly 
    23450                 23455                 23460             


Ser Gln   Val Thr Gly Tyr Ile   Val Glu Arg Lys Glu   Val Arg Ala 
    23465                 23470                 23475             


Asp Arg   Trp Val Arg Val Asn   Lys Val Pro Val Thr   Met Thr Arg 
    23480                 23485                 23490             


Tyr Arg   Ser Thr Gly Leu Thr   Glu Gly Leu Glu Tyr   Glu His Arg 
    23495                 23500                 23505             


Val Thr   Ala Ile Asn Ala Arg   Gly Ser Gly Lys Pro   Ser Arg Pro 
    23510                 23515                 23520             


Ser Lys   Pro Ile Val Ala Met   Asp Pro Ile Ala Pro   Pro Gly Lys 
    23525                 23530                 23535             


Pro Gln   Asn Pro Arg Val Thr   Asp Thr Thr Arg Thr   Ser Val Ser 
    23540                 23545                 23550             


Leu Ala   Trp Ser Val Pro Glu   Asp Glu Gly Gly Ser   Lys Val Thr 
    23555                 23560                 23565             


Gly Tyr   Leu Ile Glu Met Gln   Lys Val Asp Gln His   Glu Trp Thr 
    23570                 23575                 23580             


Lys Cys   Asn Thr Thr Pro Thr   Lys Ile Arg Glu Tyr   Thr Leu Thr 
    23585                 23590                 23595             


His Leu   Pro Gln Gly Ala Glu   Tyr Arg Phe Arg Val   Leu Ala Cys 
    23600                 23605                 23610             


Asn Ala   Gly Gly Pro Gly Glu   Pro Ala Glu Val Pro   Gly Thr Val 
    23615                 23620                 23625             


Lys Val   Thr Glu Met Leu Glu   Tyr Pro Asp Tyr Glu   Leu Asp Glu 
    23630                 23635                 23640             


Arg Tyr   Gln Glu Gly Ile Phe   Val Arg Gln Gly Gly   Val Ile Arg 
    23645                 23650                 23655             


Leu Thr   Ile Pro Ile Lys Gly   Lys Pro Phe Pro Ile   Cys Lys Trp 
    23660                 23665                 23670             


Thr Lys   Glu Gly Gln Asp Ile   Ser Lys Arg Ala Met   Ile Ala Thr 
    23675                 23680                 23685             


Ser Glu   Thr His Thr Glu Leu   Val Ile Lys Glu Ala   Asp Arg Gly 
    23690                 23695                 23700             


Asp Ser   Gly Thr Tyr Asp Leu   Val Leu Glu Asn Lys   Cys Gly Lys 
    23705                 23710                 23715             


Lys Ala   Val Tyr Ile Lys Val   Arg Val Ile Gly Ser   Pro Asn Ser 
    23720                 23725                 23730             


Pro Glu   Gly Pro Leu Glu Tyr   Asp Asp Ile Gln Val   Arg Ser Val 
    23735                 23740                 23745             


Arg Val   Ser Trp Arg Pro Pro   Ala Asp Asp Gly Gly   Ala Asp Ile 
    23750                 23755                 23760             


Leu Gly   Tyr Ile Leu Glu Arg   Arg Glu Val Pro Lys   Ala Ala Trp 
    23765                 23770                 23775             


Tyr Thr   Ile Asp Ser Arg Val   Arg Gly Thr Ser Leu   Val Val Lys 
    23780                 23785                 23790             


Gly Leu   Lys Glu Asn Val Glu   Tyr His Phe Arg Val   Ser Ala Glu 
    23795                 23800                 23805             


Asn Gln   Phe Gly Ile Ser Lys   Pro Leu Lys Ser Glu   Glu Pro Val 
    23810                 23815                 23820             


Thr Pro   Lys Thr Pro Leu Asn   Pro Pro Glu Pro Pro   Ser Asn Pro 
    23825                 23830                 23835             


Pro Glu   Val Leu Asp Val Thr   Lys Ser Ser Val Ser   Leu Ser Trp 
    23840                 23845                 23850             


Ser Arg   Pro Lys Asp Asp Gly   Gly Ser Arg Val Thr   Gly Tyr Tyr 
    23855                 23860                 23865             


Ile Glu   Arg Lys Glu Thr Ser   Thr Asp Lys Trp Val   Arg His Asn 
    23870                 23875                 23880             


Lys Thr   Gln Ile Thr Thr Thr   Met Tyr Thr Val Thr   Gly Leu Val 
    23885                 23890                 23895             


Pro Asp   Ala Glu Tyr Gln Phe   Arg Ile Ile Ala Gln   Asn Asp Val 
    23900                 23905                 23910             


Gly Leu   Ser Glu Thr Ser Pro   Ala Ser Glu Pro Val   Val Cys Lys 
    23915                 23920                 23925             


Asp Pro   Phe Asp Lys Pro Ser   Gln Pro Gly Glu Leu   Glu Ile Leu 
    23930                 23935                 23940             


Ser Ile   Ser Lys Asp Ser Val   Thr Leu Gln Trp Glu   Lys Pro Glu 
    23945                 23950                 23955             


Cys Asp   Gly Gly Lys Glu Ile   Leu Gly Tyr Trp Val   Glu Tyr Arg 
    23960                 23965                 23970             


Gln Ser   Gly Asp Ser Ala Trp   Lys Lys Ser Asn Lys   Glu Arg Ile 
    23975                 23980                 23985             


Lys Asp   Lys Gln Phe Thr Ile   Gly Gly Leu Leu Glu   Ala Thr Glu 
    23990                 23995                 24000             


Tyr Glu   Phe Arg Val Phe Ala   Glu Asn Glu Thr Gly   Leu Ser Arg 
    24005                 24010                 24015             


Pro Arg   Arg Thr Ala Met Ser   Ile Lys Thr Lys Leu   Thr Ser Gly 
    24020                 24025                 24030             


Glu Ala   Pro Gly Ile Arg Lys   Glu Met Lys Asp Val   Thr Thr Lys 
    24035                 24040                 24045             


Leu Gly   Glu Ala Ala Gln Leu   Ser Cys Gln Ile Val   Gly Arg Pro 
    24050                 24055                 24060             


Leu Pro   Asp Ile Lys Trp Tyr   Arg Phe Gly Lys Glu   Leu Ile Gln 
    24065                 24070                 24075             


Ser Arg   Lys Tyr Lys Met Ser   Ser Asp Gly Arg Thr   His Thr Leu 
    24080                 24085                 24090             


Thr Val   Met Thr Glu Glu Gln   Glu Asp Glu Gly Val   Tyr Thr Cys 
    24095                 24100                 24105             


Ile Ala   Thr Asn Glu Val Gly   Glu Val Glu Thr Ser   Ser Lys Leu 
    24110                 24115                 24120             


Leu Leu   Gln Ala Thr Pro Gln   Phe His Pro Gly Tyr   Pro Leu Lys 
    24125                 24130                 24135             


Glu Lys   Tyr Tyr Gly Ala Val   Gly Ser Thr Leu Arg   Leu His Val 
    24140                 24145                 24150             


Met Tyr   Ile Gly Arg Pro Val   Pro Ala Met Thr Trp   Phe His Gly 
    24155                 24160                 24165             


Gln Lys   Leu Leu Gln Asn Ser   Glu Asn Ile Thr Ile   Glu Asn Thr 
    24170                 24175                 24180             


Glu His   Tyr Thr His Leu Val   Met Lys Asn Val Gln   Arg Lys Thr 
    24185                 24190                 24195             


His Ala   Gly Lys Tyr Lys Val   Gln Leu Ser Asn Val   Phe Gly Thr 
    24200                 24205                 24210             


Val Asp   Ala Ile Leu Asp Val   Glu Ile Gln Asp Lys   Pro Asp Lys 
    24215                 24220                 24225             


Pro Thr   Gly Pro Ile Val Ile   Glu Ala Leu Leu Lys   Asn Ser Ala 
    24230                 24235                 24240             


Val Ile   Ser Trp Lys Pro Pro   Ala Asp Asp Gly Gly   Ser Trp Ile 
    24245                 24250                 24255             


Thr Asn   Tyr Val Val Glu Lys   Cys Glu Ala Lys Glu   Gly Ala Glu 
    24260                 24265                 24270             


Trp Gln   Leu Val Ser Ser Ala   Ile Ser Val Thr Thr   Cys Arg Ile 
    24275                 24280                 24285             


Val Asn   Leu Thr Glu Asn Ala   Gly Tyr Tyr Phe Arg   Val Ser Ala 
    24290                 24295                 24300             


Gln Asn   Thr Phe Gly Ile Ser   Asp Pro Leu Glu Val   Ser Ser Val 
    24305                 24310                 24315             


Val Ile   Ile Lys Ser Pro Phe   Glu Lys Pro Gly Ala   Pro Gly Lys 
    24320                 24325                 24330             


Pro Thr   Ile Thr Ala Val Thr   Lys Asp Ser Cys Val   Val Ala Trp 
    24335                 24340                 24345             


Lys Pro   Pro Ala Ser Asp Gly   Gly Ala Lys Ile Arg   Asn Tyr Tyr 
    24350                 24355                 24360             


Leu Glu   Lys Arg Glu Lys Lys   Gln Asn Lys Trp Ile   Ser Val Thr 
    24365                 24370                 24375             


Thr Glu   Glu Ile Arg Glu Thr   Val Phe Ser Val Lys   Asn Leu Ile 
    24380                 24385                 24390             


Glu Gly   Leu Glu Tyr Glu Phe   Arg Val Lys Cys Glu   Asn Leu Gly 
    24395                 24400                 24405             


Gly Glu   Ser Glu Trp Ser Glu   Ile Ser Glu Pro Ile   Thr Pro Lys 
    24410                 24415                 24420             


Ser Asp   Val Pro Ile Gln Ala   Pro His Phe Lys Glu   Glu Leu Arg 
    24425                 24430                 24435             


Asn Leu   Asn Val Arg Tyr Gln   Ser Asn Ala Thr Leu   Val Cys Lys 
    24440                 24445                 24450             


Val Thr   Gly His Pro Lys Pro   Ile Val Lys Trp Tyr   Arg Gln Gly 
    24455                 24460                 24465             


Lys Glu   Ile Ile Ala Asp Gly   Leu Lys Tyr Arg Ile   Gln Glu Phe 
    24470                 24475                 24480             


Lys Gly   Gly Tyr His Gln Leu   Ile Ile Ala Ser Val   Thr Asp Asp 
    24485                 24490                 24495             


Asp Ala   Thr Val Tyr Gln Val   Arg Ala Thr Asn Gln   Gly Gly Ser 
    24500                 24505                 24510             


Val Ser   Gly Thr Ala Ser Leu   Glu Val Glu Val Pro   Ala Lys Ile 
    24515                 24520                 24525             


His Leu   Pro Lys Thr Leu Glu   Gly Met Gly Ala Val   His Ala Leu 
    24530                 24535                 24540             


Arg Gly   Glu Val Val Ser Ile   Lys Ile Pro Phe Ser   Gly Lys Pro 
    24545                 24550                 24555             


Asp Pro   Val Ile Thr Trp Gln   Lys Gly Gln Asp Leu   Ile Asp Asn 
    24560                 24565                 24570             


Asn Gly   His Tyr Gln Val Ile   Val Thr Arg Ser Phe   Thr Ser Leu 
    24575                 24580                 24585             


Val Phe   Pro Asn Gly Val Glu   Arg Lys Asp Ala Gly   Phe Tyr Val 
    24590                 24595                 24600             


Val Cys   Ala Lys Asn Arg Phe   Gly Ile Asp Gln Lys   Thr Val Glu 
    24605                 24610                 24615             


Leu Asp   Val Ala Asp Val Pro   Asp Pro Pro Arg Gly   Val Lys Val 
    24620                 24625                 24630             


Ser Asp   Val Ser Arg Asp Ser   Val Asn Leu Thr Trp   Thr Glu Pro 
    24635                 24640                 24645             


Ala Ser   Asp Gly Gly Ser Lys   Ile Thr Asn Tyr Ile   Val Glu Lys 
    24650                 24655                 24660             


Cys Ala   Thr Thr Ala Glu Arg   Trp Leu Arg Val Gly   Gln Ala Arg 
    24665                 24670                 24675             


Glu Thr   Arg Tyr Thr Val Ile   Asn Leu Phe Gly Lys   Thr Ser Tyr 
    24680                 24685                 24690             


Gln Phe   Arg Val Ile Ala Glu   Asn Lys Phe Gly Leu   Ser Lys Pro 
    24695                 24700                 24705             


Ser Glu   Pro Ser Glu Pro Thr   Ile Thr Lys Glu Asp   Lys Thr Arg 
    24710                 24715                 24720             


Ala Met   Asn Tyr Asp Glu Glu   Val Asp Glu Thr Arg   Glu Val Ser 
    24725                 24730                 24735             


Met Thr   Lys Ala Ser His Ser   Ser Thr Lys Glu Leu   Tyr Glu Lys 
    24740                 24745                 24750             


Tyr Met   Ile Ala Glu Asp Leu   Gly Arg Gly Glu Phe   Gly Ile Val 
    24755                 24760                 24765             


His Arg   Cys Val Glu Thr Ser   Ser Lys Lys Thr Tyr   Met Ala Lys 
    24770                 24775                 24780             


Phe Val   Lys Val Lys Gly Thr   Asp Gln Val Leu Val   Lys Lys Glu 
    24785                 24790                 24795             


Ile Ser   Ile Leu Asn Ile Ala   Arg His Arg Asn Ile   Leu His Leu 
    24800                 24805                 24810             


His Glu   Ser Phe Glu Ser Met   Glu Glu Leu Val Met   Ile Phe Glu 
    24815                 24820                 24825             


Phe Ile   Ser Gly Leu Asp Ile   Phe Glu Arg Ile Asn   Thr Ser Ala 
    24830                 24835                 24840             


Phe Glu   Leu Asn Glu Arg Glu   Ile Val Ser Tyr Val   His Gln Val 
    24845                 24850                 24855             


Cys Glu   Ala Leu Gln Phe Leu   His Ser His Asn Ile   Gly His Phe 
    24860                 24865                 24870             


Asp Ile   Arg Pro Glu Asn Ile   Ile Tyr Gln Thr Arg   Arg Ser Ser 
    24875                 24880                 24885             


Thr Ile   Lys Ile Ile Glu Phe   Gly Gln Ala Arg Gln   Leu Lys Pro 
    24890                 24895                 24900             


Gly Asp   Asn Phe Arg Leu Leu   Phe Thr Ala Pro Glu   Tyr Tyr Ala 
    24905                 24910                 24915             


Pro Glu   Val His Gln His Asp   Val Val Ser Thr Ala   Thr Asp Met 
    24920                 24925                 24930             


Trp Ser   Leu Gly Thr Leu Val   Tyr Val Leu Leu Ser   Gly Ile Asn 
    24935                 24940                 24945             


Pro Phe   Leu Ala Glu Thr Asn   Gln Gln Ile Ile Glu   Asn Ile Met 
    24950                 24955                 24960             


Asn Ala   Glu Tyr Thr Phe Asp   Glu Glu Ala Phe Lys   Glu Ile Ser 
    24965                 24970                 24975             


Ile Glu   Ala Met Asp Phe Val   Asp Arg Leu Leu Val   Lys Glu Arg 
    24980                 24985                 24990             


Lys Ser   Arg Met Thr Ala Ser   Glu Ala Leu Gln His   Pro Trp Leu 
    24995                 25000                 25005             


Lys Gln   Lys Ile Glu Arg Val   Ser Thr Lys Val Ile   Arg Thr Leu 
    25010                 25015                 25020             


Lys His   Arg Arg Tyr Tyr His   Thr Leu Ile Lys Lys   Asp Leu Asn 
    25025                 25030                 25035             


Met Val   Val Ser Ala Ala Arg   Ile Ser Cys Gly Gly   Ala Ile Arg 
    25040                 25045                 25050             


Ser Gln   Lys Gly Val Ser Val   Ala Lys Val Lys Val   Ala Ser Ile 
    25055                 25060                 25065             


Glu Ile   Gly Pro Val Ser Gly   Gln Ile Met His Ala   Val Gly Glu 
    25070                 25075                 25080             


Glu Gly   Gly His Val Lys Tyr   Val Cys Lys Ile Glu   Asn Tyr Asp 
    25085                 25090                 25095             


Gln Ser   Thr Gln Val Thr Trp   Tyr Phe Gly Val Arg   Gln Leu Glu 
    25100                 25105                 25110             


Asn Ser   Glu Lys Tyr Glu Ile   Thr Tyr Glu Asp Gly   Val Ala Ile 
    25115                 25120                 25125             


Leu Tyr   Val Lys Asp Ile Thr   Lys Leu Asp Asp Gly   Thr Tyr Arg 
    25130                 25135                 25140             


Cys Lys   Val Val Asn Asp Tyr   Gly Glu Asp Ser Ser   Tyr Ala Glu 
    25145                 25150                 25155             


Leu Phe   Val Lys Gly Val Arg   Glu Val Tyr Asp Tyr   Tyr Cys Arg 
    25160                 25165                 25170             


Arg Thr   Met Lys Lys Ile Lys   Arg Arg Thr Asp Thr   Met Arg Leu 
    25175                 25180                 25185             


Leu Glu   Arg Pro Pro Glu Phe   Thr Leu Pro Leu Tyr   Asn Lys Thr 
    25190                 25195                 25200             


Ala Tyr   Val Gly Glu Asn Val   Arg Phe Gly Val Thr   Ile Thr Val 
    25205                 25210                 25215             


His Pro   Glu Pro His Val Thr   Trp Tyr Lys Ser Gly   Gln Lys Ile 
    25220                 25225                 25230             


Lys Pro   Gly Asp Asn Asp Lys   Lys Tyr Thr Phe Glu   Ser Asp Lys 
    25235                 25240                 25245             


Gly Leu   Tyr Gln Leu Thr Ile   Asn Ser Val Thr Thr   Asp Asp Asp 
    25250                 25255                 25260             


Ala Glu   Tyr Thr Val Val Ala   Arg Asn Lys Tyr Gly   Glu Asp Ser 
    25265                 25270                 25275             


Cys Lys   Ala Lys Leu Thr Val   Thr Leu His Pro Pro   Pro Thr Asp 
    25280                 25285                 25290             


Ser Thr   Leu Arg Pro Met Phe   Lys Arg Leu Leu Ala   Asn Ala Glu 
    25295                 25300                 25305             


Cys Gln   Glu Gly Gln Ser Val   Cys Phe Glu Ile Arg   Val Ser Gly 
    25310                 25315                 25320             


Ile Pro   Pro Pro Thr Leu Lys   Trp Glu Lys Asp Gly   Gln Pro Leu 
    25325                 25330                 25335             


Ser Leu   Gly Pro Asn Ile Glu   Ile Ile His Glu Gly   Leu Asp Tyr 
    25340                 25345                 25350             


Tyr Ala   Leu His Ile Arg Asp   Thr Leu Pro Glu Asp   Thr Gly Tyr 
    25355                 25360                 25365             


Tyr Arg   Val Thr Ala Thr Asn   Thr Ala Gly Ser Thr   Ser Cys Gln 
    25370                 25375                 25380             


Ala His   Leu Gln Val Glu Arg   Leu Arg Tyr Lys Lys   Gln Glu Phe 
    25385                 25390                 25395             


Lys Ser   Lys Glu Glu His Glu   Arg His Val Gln Lys   Gln Ile Asp 
    25400                 25405                 25410             


Lys Thr   Leu Arg Met Ala Glu   Ile Leu Ser Gly Thr   Glu Ser Val 
    25415                 25420                 25425             


Pro Leu   Thr Gln Val Ala Lys   Glu Ala Leu Arg Glu   Ala Ala Val 
    25430                 25435                 25440             


Leu Tyr   Lys Pro Ala Val Ser   Thr Lys Thr Val Lys   Gly Glu Phe 
    25445                 25450                 25455             


Arg Leu   Glu Ile Glu Glu Lys   Lys Glu Glu Arg Lys   Leu Arg Met 
    25460                 25465                 25470             


Pro Tyr   Asp Val Pro Glu Pro   Arg Lys Tyr Lys Gln   Thr Thr Ile 
    25475                 25480                 25485             


Glu Glu   Asp Gln Arg Ile Lys   Gln Phe Val Pro Met   Ser Asp Met 
    25490                 25495                 25500             


Lys Trp   Tyr Lys Lys Ile Arg   Asp Gln Tyr Glu Met   Pro Gly Lys 
    25505                 25510                 25515             


Leu Asp   Arg Val Val Gln Lys   Arg Pro Lys Arg Ile   Arg Leu Ser 
    25520                 25525                 25530             


Arg Trp   Glu Gln Phe Tyr Val   Met Pro Leu Pro Arg   Ile Thr Asp 
    25535                 25540                 25545             


Gln Tyr   Arg Pro Lys Trp Arg   Ile Pro Lys Leu Ser   Gln Asp Asp 
    25550                 25555                 25560             


Leu Glu   Ile Val Arg Pro Ala   Arg Arg Arg Thr Pro   Ser Pro Asp 
    25565                 25570                 25575             


Tyr Asp   Phe Tyr Tyr Arg Pro   Arg Arg Arg Ser Leu   Gly Asp Ile 
    25580                 25585                 25590             


Ser Asp   Glu Glu Leu Leu Leu   Pro Ile Asp Asp Tyr   Leu Ala Met 
    25595                 25600                 25605             


Lys Arg   Thr Glu Glu Glu Arg   Leu Arg Leu Glu Glu   Glu Leu Glu 
    25610                 25615                 25620             


Leu Gly   Phe Ser Ala Ser Pro   Pro Ser Arg Ser Pro   Pro His Phe 
    25625                 25630                 25635             


Glu Leu   Ser Ser Leu Arg Tyr   Ser Ser Pro Gln Ala   His Val Lys 
    25640                 25645                 25650             


Val Glu   Glu Thr Arg Lys Asp   Phe Arg Tyr Ser Thr   Tyr His Ile 
    25655                 25660                 25665             


Pro Thr   Lys Ala Glu Ala Ser   Thr Ser Tyr Ala Glu   Leu Arg Glu 
    25670                 25675                 25680             


Arg His   Ala Gln Ala Ala Tyr   Arg Gln Pro Lys Gln   Arg Gln Arg 
    25685                 25690                 25695             


Ile Met   Ala Glu Arg Glu Asp   Glu Glu Leu Leu Arg   Pro Val Thr 
    25700                 25705                 25710             


Thr Thr   Gln His Leu Ser Glu   Tyr Lys Ser Glu Leu   Asp Phe Met 
    25715                 25720                 25725             


Ser Lys   Glu Glu Lys Ser Arg   Lys Lys Ser Arg Arg   Gln Arg Glu 
    25730                 25735                 25740             


Val Thr   Glu Ile Thr Glu Ile   Glu Glu Glu Tyr Glu   Ile Ser Lys 
    25745                 25750                 25755             


His Ala   Gln Arg Glu Ser Ser   Ser Ser Ala Ser Arg   Leu Leu Arg 
    25760                 25765                 25770             


Arg Arg   Arg Ser Leu Ser Pro   Thr Tyr Ile Glu Leu   Met Arg Pro 
    25775                 25780                 25785             


Val Ser   Glu Leu Ile Arg Ser   Arg Pro Gln Pro Ala   Glu Glu Tyr 
    25790                 25795                 25800             


Glu Asp   Asp Thr Glu Arg Arg   Ser Pro Thr Pro Glu   Arg Thr Arg 
    25805                 25810                 25815             


Pro Arg   Ser Pro Ser Pro Val   Ser Ser Glu Arg Ser   Leu Ser Arg 
    25820                 25825                 25830             


Phe Glu   Arg Ser Ala Arg Phe   Asp Ile Phe Ser Arg   Tyr Glu Ser 
    25835                 25840                 25845             


Met Lys   Ala Ala Leu Lys Thr   Gln Lys Thr Ser Glu   Arg Lys Tyr 
    25850                 25855                 25860             


Glu Val   Leu Ser Gln Gln Pro   Phe Thr Leu Asp His   Ala Pro Arg 
    25865                 25870                 25875             


Ile Thr   Leu Arg Met Arg Ser   His Arg Val Pro Cys   Gly Gln Asn 
    25880                 25885                 25890             


Thr Arg   Phe Ile Leu Asn Val   Gln Ser Lys Pro Thr   Ala Glu Val 
    25895                 25900                 25905             


Lys Trp   Tyr His Asn Gly Val   Glu Leu Gln Glu Ser   Ser Lys Ile 
    25910                 25915                 25920             


His Tyr   Thr Asn Thr Ser Gly   Val Leu Thr Leu Glu   Ile Leu Asp 
    25925                 25930                 25935             


Cys His   Thr Asp Asp Ser Gly   Thr Tyr Arg Ala Val   Cys Thr Asn 
    25940                 25945                 25950             


Tyr Lys   Gly Glu Ala Ser Asp   Tyr Ala Thr Leu Asp   Val Thr Gly 
    25955                 25960                 25965             


Gly Asp   Tyr Thr Thr Tyr Ala   Ser Gln Arg Arg Asp   Glu Glu Val 
    25970                 25975                 25980             


Pro Arg   Ser Val Phe Pro Glu   Leu Thr Arg Thr Glu   Ala Tyr Ala 
    25985                 25990                 25995             


Val Ser   Ser Phe Lys Lys Thr   Ser Glu Met Glu Ala   Ser Ser Ser 
    26000                 26005                 26010             


Val Arg   Glu Val Lys Ser Gln   Met Thr Glu Thr Arg   Glu Ser Leu 
    26015                 26020                 26025             


Ser Ser   Tyr Glu His Ser Ala   Ser Ala Glu Met Lys   Ser Ala Ala 
    26030                 26035                 26040             


Leu Glu   Glu Lys Ser Leu Glu   Glu Lys Ser Thr Thr   Arg Lys Ile 
    26045                 26050                 26055             


Lys Thr   Thr Leu Ala Ala Arg   Ile Leu Thr Lys Pro   Arg Ser Met 
    26060                 26065                 26070             


Thr Val   Tyr Glu Gly Glu Ser   Ala Arg Phe Ser Cys   Asp Thr Asp 
    26075                 26080                 26085             


Gly Glu   Pro Val Pro Thr Val   Thr Trp Leu Arg Lys   Gly Gln Val 
    26090                 26095                 26100             


Leu Ser   Thr Ser Ala Arg His   Gln Val Thr Thr Thr   Lys Tyr Lys 
    26105                 26110                 26115             


Ser Thr   Phe Glu Ile Ser Ser   Val Gln Ala Ser Asp   Glu Gly Asn 
    26120                 26125                 26130             


Tyr Ser   Val Val Val Glu Asn   Ser Glu Gly Lys Gln   Glu Ala Glu 
    26135                 26140                 26145             


Phe Thr   Leu Thr Ile Gln Lys   Ala Arg Val Thr Glu   Lys Ala Val 
    26150                 26155                 26160             


Thr Ser   Pro Pro Arg Val Lys   Ser Pro Glu Pro Arg   Val Lys Ser 
    26165                 26170                 26175             


Pro Glu   Ala Val Lys Ser Pro   Lys Arg Val Lys Ser   Pro Glu Pro 
    26180                 26185                 26190             


Ser His   Pro Lys Ala Val Ser   Pro Thr Glu Thr Lys   Pro Thr Pro 
    26195                 26200                 26205             


Thr Glu   Lys Val Gln His Leu   Pro Val Ser Ala Pro   Pro Lys Ile 
    26210                 26215                 26220             


Thr Gln   Phe Leu Lys Ala Glu   Ala Ser Lys Glu Ile   Ala Lys Leu 
    26225                 26230                 26235             


Thr Cys   Val Val Glu Ser Ser   Val Leu Arg Ala Lys   Glu Val Thr 
    26240                 26245                 26250             


Trp Tyr   Lys Asp Gly Lys Lys   Leu Lys Glu Asn Gly   His Phe Gln 
    26255                 26260                 26265             


Phe His   Tyr Ser Ala Asp Gly   Thr Tyr Glu Leu Lys   Ile Asn Asn 
    26270                 26275                 26280             


Leu Thr   Glu Ser Asp Gln Gly   Glu Tyr Val Cys Glu   Ile Ser Gly 
    26285                 26290                 26295             


Glu Gly   Gly Thr Ser Lys Thr   Asn Leu Gln Phe Met   Gly Gln Ala 
    26300                 26305                 26310             


Phe Lys   Ser Ile His Glu Lys   Val Ser Lys Ile Ser   Glu Thr Lys 
    26315                 26320                 26325             


Lys Ser   Asp Gln Lys Thr Thr   Glu Ser Thr Val Thr   Arg Lys Thr 
    26330                 26335                 26340             


Glu Pro   Lys Ala Pro Glu Pro   Ile Ser Ser Lys Pro   Val Ile Val 
    26345                 26350                 26355             


Thr Gly   Leu Gln Asp Thr Thr   Val Ser Ser Asp Ser   Val Ala Lys 
    26360                 26365                 26370             


Phe Ala   Val Lys Ala Thr Gly   Glu Pro Arg Pro Thr   Ala Ile Trp 
    26375                 26380                 26385             


Thr Lys   Asp Gly Lys Ala Ile   Thr Gln Gly Gly Lys   Tyr Lys Leu 
    26390                 26395                 26400             


Ser Glu   Asp Lys Gly Gly Phe   Phe Leu Glu Ile His   Lys Thr Asp 
    26405                 26410                 26415             


Thr Ser   Asp Ser Gly Leu Tyr   Thr Cys Thr Val Lys   Asn Ser Ala 
    26420                 26425                 26430             


Gly Ser   Val Ser Ser Ser Cys   Lys Leu Thr Ile Lys   Ala Ile Lys 
    26435                 26440                 26445             


Asp Thr   Glu Ala Gln Lys Val   Ser Thr Gln Lys Thr   Ser Glu Ile 
    26450                 26455                 26460             


Thr Pro   Gln Lys Lys Ala Val   Val Gln Glu Glu Ile   Ser Gln Lys 
    26465                 26470                 26475             


Ala Leu   Arg Ser Glu Glu Ile   Lys Met Ser Glu Ala   Lys Ser Gln 
    26480                 26485                 26490             


Glu Lys   Leu Ala Leu Lys Glu   Glu Ala Ser Lys Val   Leu Ile Ser 
    26495                 26500                 26505             


Glu Glu   Val Lys Lys Ser Ala   Ala Thr Ser Leu Glu   Lys Ser Ile 
    26510                 26515                 26520             


Val His   Glu Glu Ile Thr Lys   Thr Ser Gln Ala Ser   Glu Glu Val 
    26525                 26530                 26535             


Arg Thr   His Ala Glu Ile Lys   Ala Phe Ser Thr Gln   Met Ser Ile 
    26540                 26545                 26550             


Asn Glu   Gly Gln Arg Leu Val   Leu Lys Ala Asn Ile   Ala Gly Ala 
    26555                 26560                 26565             


Thr Asp   Val Lys Trp Val Leu   Asn Gly Val Glu Leu   Thr Asn Ser 
    26570                 26575                 26580             


Glu Glu   Tyr Arg Tyr Gly Val   Ser Gly Ser Asp Gln   Thr Leu Thr 
    26585                 26590                 26595             


Ile Lys   Gln Ala Ser His Arg   Asp Glu Gly Ile Leu   Thr Cys Ile 
    26600                 26605                 26610             


Ser Lys   Thr Lys Glu Gly Ile   Val Lys Cys Gln Tyr   Asp Leu Thr 
    26615                 26620                 26625             


Leu Ser   Lys Glu Leu Ser Asp   Ala Pro Ala Phe Ile   Ser Gln Pro 
    26630                 26635                 26640             


Arg Ser   Gln Asn Ile Asn Glu   Gly Gln Asn Val Leu   Phe Thr Cys 
    26645                 26650                 26655             


Glu Ile   Ser Gly Glu Pro Ser   Pro Glu Ile Glu Trp   Phe Lys Asn 
    26660                 26665                 26670             


Asn Leu   Pro Ile Ser Ile Ser   Ser Asn Val Ser Ile   Ser Arg Ser 
    26675                 26680                 26685             


Arg Asn   Val Tyr Ser Leu Glu   Ile Arg Asn Ala Ser   Val Ser Asp 
    26690                 26695                 26700             


Ser Gly   Lys Tyr Thr Ile Lys   Ala Lys Asn Phe Arg   Gly Gln Cys 
    26705                 26710                 26715             


Ser Ala   Thr Ala Ser Leu Met   Val Leu Pro Leu Val   Glu Glu Pro 
    26720                 26725                 26730             


Ser Arg   Glu Val Val Leu Arg   Thr Ser Gly Asp Thr   Ser Leu Gln 
    26735                 26740                 26745             


Gly Ser   Phe Ser Ser Gln Ser   Val Gln Met Ser Ala   Ser Lys Gln 
    26750                 26755                 26760             


Glu Ala   Ser Phe Ser Ser Phe   Ser Ser Ser Ser Ala   Ser Ser Met 
    26765                 26770                 26775             


Thr Glu   Met Lys Phe Ala Ser   Met Ser Ala Gln Ser   Met Ser Ser 
    26780                 26785                 26790             


Met Gln   Glu Ser Phe Val Glu   Met Ser Ser Ser Ser   Phe Met Gly 
    26795                 26800                 26805             


Ile Ser   Asn Met Thr Gln Leu   Glu Ser Ser Thr Ser   Lys Met Leu 
    26810                 26815                 26820             


Lys Ala   Gly Ile Arg Gly Ile   Pro Pro Lys Ile Glu   Ala Leu Pro 
    26825                 26830                 26835             


Ser Asp   Ile Ser Ile Asp Glu   Gly Lys Val Leu Thr   Val Ala Cys 
    26840                 26845                 26850             


Ala Phe   Thr Gly Glu Pro Thr   Pro Glu Val Thr Trp   Ser Cys Gly 
    26855                 26860                 26865             


Gly Arg   Lys Ile His Ser Gln   Glu Gln Gly Arg Phe   His Ile Glu 
    26870                 26875                 26880             


Asn Thr   Asp Asp Leu Thr Thr   Leu Ile Ile Met Asp   Val Gln Lys 
    26885                 26890                 26895             


Gln Asp   Gly Gly Leu Tyr Thr   Leu Ser Leu Gly Asn   Glu Phe Gly 
    26900                 26905                 26910             


Ser Asp   Ser Ala Thr Val Asn   Ile His Ile Arg Ser   Ile 
    26915                 26920                 26925     


<210>  7666
<211>  27118
<212>  PRT
<213>  Homo sapiens

<400>  7666

Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro Pro Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Met Lys Glu Thr Arg 
545                 550                 555                 560 


Lys Thr Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu 
                565                 570                 575     


Gln Asp Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu 
            580                 585                 590         


Gln Val Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr 
        595                 600                 605             


Ala Leu Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu 
    610                 615                 620                 


Thr Ile Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile 
625                 630                 635                 640 


Gln Val Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val 
                645                 650                 655     


Ala Thr Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg 
            660                 665                 670         


Glu Pro Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu 
        675                 680                 685             


Tyr Gly Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro 
    690                 695                 700                 


Gln Arg Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro 
705                 710                 715                 720 


Arg Val Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln 
                725                 730                 735     


Lys Gly Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr 
            740                 745                 750         


Thr Glu Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro 
        755                 760                 765             


His Phe Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr 
    770                 775                 780                 


Glu Ala Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu 
785                 790                 795                 800 


Ser Ala Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro 
                805                 810                 815     


Thr Val Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu 
            820                 825                 830         


Pro Gln Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala 
        835                 840                 845             


Gly Val Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr 
    850                 855                 860                 


Val Arg Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val 
865                 870                 875                 880 


Thr Glu Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro 
                885                 890                 895     


Pro Thr Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu 
            900                 905                 910         


Ser Val Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val 
        915                 920                 925             


Thr Trp Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln 
    930                 935                 940                 


Ile Thr Phe Gln Ser Gly Ile Ala Arg Leu Met Ile Arg Glu Ala Phe 
945                 950                 955                 960 


Ala Glu Asp Ser Gly Arg Phe Thr Cys Ser Ala Val Asn Glu Ala Gly 
                965                 970                 975     


Thr Val Ser Thr Ser Cys Tyr Leu Ala Val Gln Val Ser Glu Glu Phe 
            980                 985                 990         


Glu Lys Glu Thr Thr Ala Val Thr  Glu Lys Phe Thr Thr  Glu Glu Lys 
        995                 1000                 1005             


Arg Phe  Val Glu Ser Arg Asp  Val Val Met Thr Asp  Thr Ser Leu 
    1010                 1015                 1020             


Thr Glu  Glu Gln Ala Gly Pro  Gly Glu Pro Ala Ala  Pro Tyr Phe 
    1025                 1030                 1035             


Ile Thr  Lys Pro Val Val Gln  Lys Leu Val Glu Gly  Gly Ser Val 
    1040                 1045                 1050             


Val Phe  Gly Cys Gln Val Gly  Gly Asn Pro Lys Pro  His Val Tyr 
    1055                 1060                 1065             


Trp Lys  Lys Ser Gly Val Pro  Leu Thr Thr Gly Tyr  Arg Tyr Lys 
    1070                 1075                 1080             


Val Ser  Tyr Asn Lys Gln Thr  Gly Glu Cys Lys Leu  Val Ile Ser 
    1085                 1090                 1095             


Met Thr  Phe Ala Asp Asp Ala  Gly Glu Tyr Thr Ile  Val Val Arg 
    1100                 1105                 1110             


Asn Lys  His Gly Glu Thr Ser  Ala Ser Ala Ser Leu  Leu Glu Glu 
    1115                 1120                 1125             


Ala Asp  Tyr Glu Leu Leu Met  Lys Ser Gln Gln Glu  Met Leu Tyr 
    1130                 1135                 1140             


Gln Thr  Gln Val Thr Ala Phe  Val Gln Glu Pro Lys  Val Gly Glu 
    1145                 1150                 1155             


Thr Ala  Pro Gly Phe Val Tyr  Ser Glu Tyr Glu Lys  Glu Tyr Glu 
    1160                 1165                 1170             


Lys Glu  Gln Ala Leu Ile Arg  Lys Lys Met Ala Lys  Asp Thr Val 
    1175                 1180                 1185             


Val Val  Arg Thr Tyr Val Glu  Asp Gln Glu Phe His  Ile Ser Ser 
    1190                 1195                 1200             


Phe Glu  Glu Arg Leu Ile Lys  Glu Ile Glu Tyr Arg  Ile Ile Lys 
    1205                 1210                 1215             


Thr Thr  Leu Glu Glu Leu Leu  Glu Glu Asp Gly Glu  Glu Lys Met 
    1220                 1225                 1230             


Ala Val  Asp Ile Ser Glu Ser  Glu Ala Val Glu Ser  Gly Phe Asp 
    1235                 1240                 1245             


Leu Arg  Ile Lys Asn Tyr Arg  Ile Leu Glu Gly Met  Gly Val Thr 
    1250                 1255                 1260             


Phe His  Cys Lys Met Ser Gly  Tyr Pro Leu Pro Lys  Ile Ala Trp 
    1265                 1270                 1275             


Tyr Lys  Asp Gly Lys Arg Ile  Lys His Gly Glu Arg  Tyr Gln Met 
    1280                 1285                 1290             


Asp Phe  Leu Gln Asp Gly Arg  Ala Ser Leu Arg Ile  Pro Val Val 
    1295                 1300                 1305             


Leu Pro  Glu Asp Glu Gly Ile  Tyr Thr Ala Phe Ala  Ser Asn Ile 
    1310                 1315                 1320             


Lys Gly  Asn Ala Ile Cys Ser  Gly Lys Leu Tyr Val  Glu Pro Ala 
    1325                 1330                 1335             


Ala Pro  Leu Gly Ala Pro Thr  Tyr Ile Pro Thr Leu  Glu Pro Val 
    1340                 1345                 1350             


Ser Arg  Ile Arg Ser Leu Ser  Pro Arg Ser Val Ser  Arg Ser Pro 
    1355                 1360                 1365             


Ile Arg  Met Ser Pro Ala Arg  Met Ser Pro Ala Arg  Met Ser Pro 
    1370                 1375                 1380             


Ala Arg  Met Ser Pro Ala Arg  Met Ser Pro Gly Arg  Arg Leu Glu 
    1385                 1390                 1395             


Glu Thr  Asp Glu Ser Gln Leu  Glu Arg Leu Tyr Lys  Pro Val Phe 
    1400                 1405                 1410             


Val Leu  Lys Pro Val Ser Phe  Lys Cys Leu Glu Gly  Gln Thr Ala 
    1415                 1420                 1425             


Arg Phe  Asp Leu Lys Val Val  Gly Arg Pro Met Pro  Glu Thr Phe 
    1430                 1435                 1440             


Trp Phe  His Asp Gly Gln Gln  Ile Val Asn Asp Tyr  Thr His Lys 
    1445                 1450                 1455             


Val Val  Ile Lys Glu Asp Gly  Thr Gln Ser Leu Ile  Ile Val Pro 
    1460                 1465                 1470             


Ala Thr  Pro Ser Asp Ser Gly  Glu Trp Thr Val Val  Ala Gln Asn 
    1475                 1480                 1485             


Arg Ala  Gly Arg Ser Ser Ile  Ser Val Ile Leu Thr  Val Glu Ala 
    1490                 1495                 1500             


Val Glu  His Gln Val Lys Pro  Met Phe Val Glu Lys  Leu Lys Asn 
    1505                 1510                 1515             


Val Asn  Ile Lys Glu Gly Ser  Arg Leu Glu Met Lys  Val Arg Ala 
    1520                 1525                 1530             


Thr Gly  Asn Pro Asn Pro Asp  Ile Val Trp Leu Lys  Asn Ser Asp 
    1535                 1540                 1545             


Ile Ile  Val Pro His Lys Tyr  Pro Lys Ile Arg Ile  Glu Gly Thr 
    1550                 1555                 1560             


Lys Gly  Glu Ala Ala Leu Lys  Ile Asp Ser Thr Val  Ser Gln Asp 
    1565                 1570                 1575             


Ser Ala  Trp Tyr Thr Ala Thr  Ala Ile Asn Lys Ala  Gly Arg Asp 
    1580                 1585                 1590             


Thr Thr  Arg Cys Lys Val Asn  Val Glu Val Glu Phe  Ala Glu Pro 
    1595                 1600                 1605             


Glu Pro  Glu Arg Lys Leu Ile  Ile Pro Arg Gly Thr  Tyr Arg Ala 
    1610                 1615                 1620             


Lys Glu  Ile Ala Ala Pro Glu  Leu Glu Pro Leu His  Leu Arg Tyr 
    1625                 1630                 1635             


Gly Gln  Glu Gln Trp Glu Glu  Gly Asp Leu Tyr Asp  Lys Glu Lys 
    1640                 1645                 1650             


Gln Gln  Lys Pro Phe Phe Lys  Lys Lys Leu Thr Ser  Leu Arg Leu 
    1655                 1660                 1665             


Lys Arg  Phe Gly Pro Ala His  Phe Glu Cys Arg Leu  Thr Pro Ile 
    1670                 1675                 1680             


Gly Asp  Pro Thr Met Val Val  Glu Trp Leu His Asp  Gly Lys Pro 
    1685                 1690                 1695             


Leu Glu  Ala Ala Asn Arg Leu  Arg Met Ile Asn Glu  Phe Gly Tyr 
    1700                 1705                 1710             


Cys Ser  Leu Asp Tyr Gly Val  Ala Tyr Ser Arg Asp  Ser Gly Ile 
    1715                 1720                 1725             


Ile Thr  Cys Arg Ala Thr Asn  Lys Tyr Gly Thr Asp  His Thr Ser 
    1730                 1735                 1740             


Ala Thr  Leu Ile Val Lys Asp  Glu Lys Ser Leu Val  Glu Glu Ser 
    1745                 1750                 1755             


Gln Leu  Pro Glu Gly Arg Lys  Gly Leu Gln Arg Ile  Glu Glu Leu 
    1760                 1765                 1770             


Glu Arg  Met Ala His Glu Gly  Ala Leu Thr Gly Val  Thr Thr Asp 
    1775                 1780                 1785             


Gln Lys  Glu Lys Gln Lys Pro  Asp Ile Val Leu Tyr  Pro Glu Pro 
    1790                 1795                 1800             


Val Arg  Val Leu Glu Gly Glu  Thr Ala Arg Phe Arg  Cys Arg Val 
    1805                 1810                 1815             


Thr Gly  Tyr Pro Gln Pro Lys  Val Asn Trp Tyr Leu  Asn Gly Gln 
    1820                 1825                 1830             


Leu Ile  Arg Lys Ser Lys Arg  Phe Arg Val Arg Tyr  Asp Gly Ile 
    1835                 1840                 1845             


His Tyr  Leu Asp Ile Val Asp  Cys Lys Ser Tyr Asp  Thr Gly Glu 
    1850                 1855                 1860             


Val Lys  Val Thr Ala Glu Asn  Pro Glu Gly Val Ile  Glu His Lys 
    1865                 1870                 1875             


Val Lys  Leu Glu Ile Gln Gln  Arg Glu Asp Phe Arg  Ser Val Leu 
    1880                 1885                 1890             


Arg Arg  Ala Pro Glu Pro Arg  Pro Glu Phe His Val  His Glu Pro 
    1895                 1900                 1905             


Gly Lys  Leu Gln Phe Glu Val  Gln Lys Val Asp Arg  Pro Val Asp 
    1910                 1915                 1920             


Thr Thr  Glu Thr Lys Glu Val  Val Lys Leu Lys Arg  Ala Glu Arg 
    1925                 1930                 1935             


Ile Thr  His Glu Lys Val Pro  Glu Glu Ser Glu Glu  Leu Arg Ser 
    1940                 1945                 1950             


Lys Phe  Lys Arg Arg Thr Glu  Glu Gly Tyr Tyr Glu  Ala Ile Thr 
    1955                 1960                 1965             


Ala Val  Glu Leu Lys Ser Arg  Lys Lys Asp Glu Ser  Tyr Glu Glu 
    1970                 1975                 1980             


Leu Leu  Arg Lys Thr Lys Asp  Glu Leu Leu His Trp  Thr Lys Glu 
    1985                 1990                 1995             


Leu Thr  Glu Glu Glu Lys Lys  Ala Leu Ala Glu Glu  Gly Lys Ile 
    2000                 2005                 2010             


Thr Ile  Pro Thr Phe Lys Pro  Asp Lys Ile Glu Leu  Ser Pro Ser 
    2015                 2020                 2025             


Met Glu  Ala Pro Lys Ile Phe  Glu Arg Ile Gln Ser  Gln Thr Val 
    2030                 2035                 2040             


Gly Gln  Gly Ser Asp Ala His  Phe Arg Val Arg Val  Val Gly Lys 
    2045                 2050                 2055             


Pro Asp  Pro Glu Cys Glu Trp  Tyr Lys Asn Gly Val  Lys Ile Glu 
    2060                 2065                 2070             


Arg Ser  Asp Arg Ile Tyr Trp  Tyr Trp Pro Glu Asp  Asn Val Cys 
    2075                 2080                 2085             


Glu Leu  Val Ile Arg Asp Val  Thr Ala Glu Asp Ser  Ala Ser Ile 
    2090                 2095                 2100             


Met Val  Lys Ala Ile Asn Ile  Ala Gly Glu Thr Ser  Ser His Ala 
    2105                 2110                 2115             


Phe Leu  Leu Val Gln Ala Lys  Gln Leu Ile Thr Phe  Thr Gln Glu 
    2120                 2125                 2130             


Leu Gln  Asp Val Val Ala Lys  Glu Lys Asp Thr Met  Ala Thr Phe 
    2135                 2140                 2145             


Glu Cys  Glu Thr Ser Glu Pro  Phe Val Lys Val Lys  Trp Tyr Lys 
    2150                 2155                 2160             


Asp Gly  Met Glu Val His Glu  Gly Asp Lys Tyr Arg  Met His Ser 
    2165                 2170                 2175             


Asp Arg  Lys Val His Phe Leu  Ser Ile Leu Thr Ile  Asp Thr Ser 
    2180                 2185                 2190             


Asp Ala  Glu Asp Tyr Ser Cys  Val Leu Val Glu Asp  Glu Asn Val 
    2195                 2200                 2205             


Lys Thr  Thr Ala Lys Leu Ile  Val Glu Gly Ala Val  Val Glu Phe 
    2210                 2215                 2220             


Val Lys  Glu Leu Gln Asp Ile  Glu Val Pro Glu Ser  Tyr Ser Gly 
    2225                 2230                 2235             


Glu Leu  Glu Cys Ile Val Ser  Pro Glu Asn Ile Glu  Gly Lys Trp 
    2240                 2245                 2250             


Tyr His  Asn Asp Val Glu Leu  Lys Ser Asn Gly Lys  Tyr Thr Ile 
    2255                 2260                 2265             


Thr Ser  Arg Arg Gly Arg Gln  Asn Leu Thr Val Lys  Asp Val Thr 
    2270                 2275                 2280             


Lys Glu  Asp Gln Gly Glu Tyr  Ser Phe Val Ile Asp  Gly Lys Lys 
    2285                 2290                 2295             


Thr Thr  Cys Lys Leu Lys Met  Lys Pro Arg Pro Ile  Ala Ile Leu 
    2300                 2305                 2310             


Gln Gly  Leu Ser Asp Gln Lys  Val Cys Glu Gly Asp  Ile Val Gln 
    2315                 2320                 2325             


Leu Glu  Val Lys Val Ser Leu  Glu Ser Val Glu Gly  Val Trp Met 
    2330                 2335                 2340             


Lys Asp  Gly Gln Glu Val Gln  Pro Ser Asp Arg Val  His Ile Val 
    2345                 2350                 2355             


Ile Asp  Lys Gln Ser His Met  Leu Leu Ile Glu Asp  Met Thr Lys 
    2360                 2365                 2370             


Glu Asp  Ala Gly Asn Tyr Ser  Phe Thr Ile Pro Ala  Leu Gly Leu 
    2375                 2380                 2385             


Ser Thr  Ser Gly Arg Val Ser  Val Tyr Ser Val Asp  Val Ile Thr 
    2390                 2395                 2400             


Pro Leu  Lys Asp Val Asn Val  Ile Glu Gly Thr Lys  Ala Val Leu 
    2405                 2410                 2415             


Glu Cys  Lys Val Ser Val Pro  Asp Val Thr Ser Val  Lys Trp Tyr 
    2420                 2425                 2430             


Leu Asn  Asp Glu Gln Ile Lys  Pro Asp Asp Arg Val  Gln Ala Ile 
    2435                 2440                 2445             


Val Lys  Gly Thr Lys Gln Arg  Leu Val Ile Asn Arg  Thr His Ala 
    2450                 2455                 2460             


Ser Asp  Glu Gly Pro Tyr Lys  Leu Ile Val Gly Arg  Val Glu Thr 
    2465                 2470                 2475             


Asn Cys  Asn Leu Ser Val Glu  Lys Ile Lys Ile Ile  Arg Gly Leu 
    2480                 2485                 2490             


Arg Asp  Leu Thr Cys Thr Glu  Thr Gln Asn Val Val  Phe Glu Val 
    2495                 2500                 2505             


Glu Leu  Ser His Ser Gly Ile  Asp Val Leu Trp Asn  Phe Lys Asp 
    2510                 2515                 2520             


Lys Glu  Ile Lys Pro Ser Ser  Lys Tyr Lys Ile Glu  Ala His Gly 
    2525                 2530                 2535             


Lys Ile  Tyr Lys Leu Thr Val  Leu Asn Met Met Lys  Asp Asp Glu 
    2540                 2545                 2550             


Gly Lys  Tyr Thr Phe Tyr Ala  Gly Glu Asn Ile Thr  Ser Gly Lys 
    2555                 2560                 2565             


Leu Thr  Val Ala Gly Gly Ala  Ile Ser Lys Pro Leu  Thr Asp Gln 
    2570                 2575                 2580             


Thr Val  Ala Glu Ser Gln Glu  Ala Val Phe Glu Cys  Glu Val Ala 
    2585                 2590                 2595             


Asn Pro  Asp Ser Lys Gly Glu  Trp Leu Arg Asp Gly  Lys His Leu 
    2600                 2605                 2610             


Pro Leu  Thr Asn Asn Ile Arg  Ser Glu Ser Asp Gly  His Lys Arg 
    2615                 2620                 2625             


Arg Leu  Ile Ile Ala Ala Thr  Lys Leu Asp Asp Ile  Gly Glu Tyr 
    2630                 2635                 2640             


Thr Tyr  Lys Val Ala Thr Ser  Lys Thr Ser Ala Lys  Leu Lys Val 
    2645                 2650                 2655             


Glu Ala  Val Lys Ile Lys Lys  Thr Leu Lys Asn Leu  Thr Val Thr 
    2660                 2665                 2670             


Glu Thr  Gln Asp Ala Val Phe  Thr Val Glu Leu Thr  His Pro Asn 
    2675                 2680                 2685             


Val Lys  Gly Val Gln Trp Ile  Lys Asn Gly Val Val  Leu Glu Ser 
    2690                 2695                 2700             


Asn Glu  Lys Tyr Ala Ile Ser  Val Lys Gly Thr Ile  Tyr Ser Leu 
    2705                 2710                 2715             


Arg Ile  Lys Asn Cys Ala Ile  Val Asp Glu Ser Val  Tyr Gly Phe 
    2720                 2725                 2730             


Arg Leu  Gly Arg Leu Gly Ala  Ser Ala Arg Leu His  Val Glu Thr 
    2735                 2740                 2745             


Val Lys  Ile Ile Lys Lys Pro  Lys Asp Val Thr Ala  Leu Glu Asn 
    2750                 2755                 2760             


Ala Thr  Val Ala Phe Glu Val  Ser Val Ser His Asp  Thr Val Pro 
    2765                 2770                 2775             


Val Lys  Trp Phe His Lys Ser  Val Glu Ile Lys Pro  Ser Asp Lys 
    2780                 2785                 2790             


His Arg  Leu Val Ser Glu Arg  Lys Val His Lys Leu  Met Leu Gln 
    2795                 2800                 2805             


Asn Ile  Ser Pro Ser Asp Ala  Gly Glu Tyr Thr Ala  Val Val Gly 
    2810                 2815                 2820             


Gln Leu  Glu Cys Lys Ala Lys  Leu Phe Val Glu Thr  Leu His Ile 
    2825                 2830                 2835             


Thr Lys  Thr Met Lys Asn Ile  Glu Val Pro Glu Thr  Lys Thr Ala 
    2840                 2845                 2850             


Ser Phe  Glu Cys Glu Val Ser  His Phe Asn Val Pro  Ser Met Trp 
    2855                 2860                 2865             


Leu Lys  Asn Gly Val Glu Ile  Glu Met Ser Glu Lys  Phe Lys Ile 
    2870                 2875                 2880             


Val Val  Gln Gly Lys Leu His  Gln Leu Ile Ile Met  Asn Thr Ser 
    2885                 2890                 2895             


Thr Glu  Asp Ser Ala Glu Tyr  Thr Phe Val Cys Gly  Asn Asp Gln 
    2900                 2905                 2910             


Val Ser  Ala Thr Leu Thr Val  Thr Pro Ile Met Ile  Thr Ser Met 
    2915                 2920                 2925             


Leu Lys  Asp Ile Asn Ala Glu  Glu Lys Asp Thr Ile  Thr Phe Glu 
    2930                 2935                 2940             


Val Thr  Val Asn Tyr Glu Gly  Ile Ser Tyr Lys Trp  Leu Lys Asn 
    2945                 2950                 2955             


Gly Val  Glu Ile Lys Ser Thr  Asp Lys Cys Gln Met  Arg Thr Lys 
    2960                 2965                 2970             


Lys Leu  Thr His Ser Leu Asn  Ile Arg Asn Val His  Phe Gly Asp 
    2975                 2980                 2985             


Ala Ala  Asp Tyr Thr Phe Val  Ala Gly Lys Ala Thr  Ser Thr Ala 
    2990                 2995                 3000             


Thr Leu  Tyr Val Glu Ala Arg  His Ile Glu Phe Arg  Lys His Ile 
    3005                 3010                 3015             


Lys Asp  Ile Lys Val Leu Glu  Lys Lys Arg Ala Met  Phe Glu Cys 
    3020                 3025                 3030             


Glu Val  Ser Glu Pro Asp Ile  Thr Val Gln Trp Met  Lys Asp Asp 
    3035                 3040                 3045             


Gln Glu  Leu Gln Ile Thr Asp  Arg Ile Lys Ile Gln  Lys Glu Lys 
    3050                 3055                 3060             


Tyr Val  His Arg Leu Leu Ile  Pro Ser Thr Arg Met  Ser Asp Ala 
    3065                 3070                 3075             


Gly Lys  Tyr Thr Val Val Ala  Gly Gly Asn Val Ser  Thr Ala Lys 
    3080                 3085                 3090             


Leu Phe  Val Glu Gly Arg Asp  Val Arg Ile Arg Ser  Ile Lys Lys 
    3095                 3100                 3105             


Glu Val  Gln Val Ile Glu Lys  Gln Arg Ala Val Val  Glu Phe Glu 
    3110                 3115                 3120             


Val Asn  Glu Asp Asp Val Asp  Ala His Trp Tyr Lys  Asp Gly Ile 
    3125                 3130                 3135             


Glu Ile  Asn Phe Gln Val Gln  Glu Arg His Lys Tyr  Val Val Glu 
    3140                 3145                 3150             


Arg Arg  Ile His Arg Met Phe  Ile Ser Glu Thr Arg  Gln Ser Asp 
    3155                 3160                 3165             


Ala Gly  Glu Tyr Thr Phe Val  Ala Gly Arg Asn Arg  Ser Ser Val 
    3170                 3175                 3180             


Thr Leu  Tyr Val Asn Ala Pro  Glu Pro Pro Gln Val  Leu Gln Glu 
    3185                 3190                 3195             


Leu Gln  Pro Val Thr Val Gln  Ser Gly Lys Pro Ala  Arg Phe Cys 
    3200                 3205                 3210             


Ala Val  Ile Ser Gly Arg Pro  Gln Pro Lys Ile Ser  Trp Tyr Lys 
    3215                 3220                 3225             


Glu Glu  Gln Leu Leu Ser Thr  Gly Phe Lys Cys Lys  Phe Leu His 
    3230                 3235                 3240             


Asp Gly  Gln Glu Tyr Thr Leu  Leu Leu Ile Glu Ala  Phe Pro Glu 
    3245                 3250                 3255             


Asp Ala  Ala Val Tyr Thr Cys  Glu Ala Lys Asn Asp  Tyr Gly Val 
    3260                 3265                 3270             


Ala Thr  Thr Ser Ala Ser Leu  Ser Val Glu Val Pro  Glu Val Val 
    3275                 3280                 3285             


Ser Pro  Asp Gln Glu Met Pro  Val Tyr Pro Pro Ala  Ile Ile Thr 
    3290                 3295                 3300             


Pro Leu  Gln Asp Thr Val Thr  Ser Glu Gly Gln Pro  Ala Arg Phe 
    3305                 3310                 3315             


Gln Cys  Arg Val Ser Gly Thr  Asp Leu Lys Val Ser  Trp Tyr Ser 
    3320                 3325                 3330             


Lys Asp  Lys Lys Ile Lys Pro  Ser Arg Phe Phe Arg  Met Thr Gln 
    3335                 3340                 3345             


Phe Glu  Asp Thr Tyr Gln Leu  Glu Ile Ala Glu Ala  Tyr Pro Glu 
    3350                 3355                 3360             


Asp Glu  Gly Thr Tyr Thr Phe  Val Ala Ser Asn Ala  Val Gly Gln 
    3365                 3370                 3375             


Val Ser  Ser Thr Ala Asn Leu  Ser Leu Glu Val Gln  Ala Leu Asp 
    3380                 3385                 3390             


Arg Gln  Ser Ser Gly Lys Asp  Val Arg Glu Ser Thr  Lys Ser Gln 
    3395                 3400                 3405             


Ala Val  Ala Asp Ser Ser Phe  Thr Lys Glu Glu Ser  Lys Ile Ser 
    3410                 3415                 3420             


Gln Lys  Glu Ile Lys Ser Phe  Gln Gly Ser Ser Tyr  Glu Tyr Glu 
    3425                 3430                 3435             


Val Gln  Val Phe Glu Ser Val  Ser Gln Ser Ser Ile  His Thr Ala 
    3440                 3445                 3450             


Ala Ser  Val Gln Asp Thr Gln  Leu Cys His Thr Ala  Ser Leu Ser 
    3455                 3460                 3465             


Gln Ile  Ala Glu Ser Thr Glu  Leu Ser Lys Glu Cys  Ala Lys Glu 
    3470                 3475                 3480             


Ser Thr  Gly Glu Ala Pro Lys  Ile Phe Leu His Leu  Gln Asp Val 
    3485                 3490                 3495             


Thr Val  Lys Cys Gly Asp Thr  Ala Gln Phe Leu Cys  Val Leu Lys 
    3500                 3505                 3510             


Asp Asp  Ser Phe Ile Asp Val  Thr Trp Thr His Glu  Gly Ala Lys 
    3515                 3520                 3525             


Ile Glu  Glu Ser Glu Arg Leu  Lys Gln Ser Gln Asn  Gly Asn Ile 
    3530                 3535                 3540             


Gln Phe  Leu Thr Ile Cys Asn  Val Gln Leu Val Asp  Gln Gly Leu 
    3545                 3550                 3555             


Tyr Ser  Cys Ile Val His Asn  Asp Cys Gly Glu Arg  Thr Thr Ser 
    3560                 3565                 3570             


Ala Val  Leu Ser Val Glu Gly  Ala Pro Glu Ser Ile  Leu His Glu 
    3575                 3580                 3585             


Arg Ile  Glu Gln Glu Ile Glu  Met Glu Met Lys Glu  Phe Ser Ser 
    3590                 3595                 3600             


Ser Phe  Leu Ser Ala Glu Glu  Glu Gly Leu His Ser  Ala Glu Leu 
    3605                 3610                 3615             


Gln Leu  Ser Lys Ile Asn Glu  Thr Leu Glu Leu Leu  Ser Glu Ser 
    3620                 3625                 3630             


Pro Val  Tyr Ser Thr Lys Phe  Asp Ser Glu Lys Glu  Gly Thr Gly 
    3635                 3640                 3645             


Pro Ile  Phe Ile Lys Glu Val  Ser Asn Ala Asp Ile  Ser Met Gly 
    3650                 3655                 3660             


Asp Val  Ala Thr Leu Ser Val  Thr Val Ile Gly Ile  Pro Lys Pro 
    3665                 3670                 3675             


Lys Ile  Gln Trp Phe Phe Asn  Gly Val Leu Leu Thr  Pro Ser Ala 
    3680                 3685                 3690             


Asp Tyr  Lys Phe Val Phe Asp  Gly Asp Asp His Ser  Leu Ile Ile 
    3695                 3700                 3705             


Leu Phe  Thr Lys Leu Glu Asp  Glu Gly Glu Tyr Thr  Cys Met Ala 
    3710                 3715                 3720             


Ser Asn  Asp Tyr Gly Lys Thr  Ile Cys Ser Ala Tyr  Leu Lys Ile 
    3725                 3730                 3735             


Asn Ser  Lys Gly Glu Gly His  Lys Asp Thr Glu Thr  Glu Ser Ala 
    3740                 3745                 3750             


Val Ala  Lys Ser Leu Glu Lys  Leu Gly Gly Pro Cys  Pro Pro His 
    3755                 3760                 3765             


Phe Leu  Lys Glu Leu Lys Pro  Ile Arg Cys Ala Gln  Gly Leu Pro 
    3770                 3775                 3780             


Ala Ile  Phe Glu Tyr Thr Val  Val Gly Glu Pro Ala  Pro Thr Val 
    3785                 3790                 3795             


Thr Trp  Phe Lys Glu Asn Lys  Gln Leu Cys Thr Ser  Val Tyr Tyr 
    3800                 3805                 3810             


Thr Ile  Ile His Asn Pro Asn  Gly Ser Gly Thr Phe  Ile Val Asn 
    3815                 3820                 3825             


Asp Pro  Gln Arg Glu Asp Ser  Gly Leu Tyr Ile Cys  Lys Ala Glu 
    3830                 3835                 3840             


Asn Met  Leu Gly Glu Ser Thr  Cys Ala Ala Glu Leu  Leu Val Leu 
    3845                 3850                 3855             


Leu Glu  Asp Thr Asp Met Thr  Asp Thr Pro Cys Lys  Ala Lys Ser 
    3860                 3865                 3870             


Thr Pro  Glu Ala Pro Glu Asp  Phe Pro Gln Thr Pro  Leu Lys Gly 
    3875                 3880                 3885             


Pro Ala  Val Glu Ala Leu Asp  Ser Glu Gln Glu Ile  Ala Thr Phe 
    3890                 3895                 3900             


Val Lys  Asp Thr Ile Leu Lys  Ala Ala Leu Ile Thr  Glu Glu Asn 
    3905                 3910                 3915             


Gln Gln  Leu Ser Tyr Glu His  Ile Ala Lys Ala Asn  Glu Leu Ser 
    3920                 3925                 3930             


Ser Gln  Leu Pro Leu Gly Ala  Gln Glu Leu Gln Ser  Ile Leu Glu 
    3935                 3940                 3945             


Gln Asp  Lys Leu Thr Pro Glu  Ser Thr Arg Glu Phe  Leu Cys Ile 
    3950                 3955                 3960             


Asn Gly  Ser Ile His Phe Gln  Pro Leu Lys Glu Pro  Ser Pro Asn 
    3965                 3970                 3975             


Leu Gln  Leu Gln Ile Val Gln  Ser Gln Lys Thr Phe  Ser Lys Glu 
    3980                 3985                 3990             


Gly Ile  Leu Met Pro Glu Glu  Pro Glu Thr Gln Ala  Val Leu Ser 
    3995                 4000                 4005             


Asp Thr  Glu Lys Ile Phe Pro  Ser Ala Met Ser Ile  Glu Gln Ile 
    4010                 4015                 4020             


Asn Ser  Leu Thr Val Glu Pro  Leu Lys Thr Leu Leu  Ala Glu Pro 
    4025                 4030                 4035             


Glu Gly  Asn Tyr Pro Gln Ser  Ser Ile Glu Pro Pro  Met His Ser 
    4040                 4045                 4050             


Tyr Leu  Thr Ser Val Ala Glu  Glu Val Leu Ser Pro  Lys Glu Lys 
    4055                 4060                 4065             


Thr Val  Ser Asp Thr Asn Arg  Glu Gln Arg Val Thr  Leu Gln Lys 
    4070                 4075                 4080             


Gln Glu  Ala Gln Ser Ala Leu  Ile Leu Ser Gln Ser  Leu Ala Glu 
    4085                 4090                 4095             


Gly His  Val Glu Ser Leu Gln  Ser Pro Asp Val Met  Ile Ser Gln 
    4100                 4105                 4110             


Val Asn  Tyr Glu Pro Leu Val  Pro Ser Glu His Ser  Cys Thr Glu 
    4115                 4120                 4125             


Gly Gly  Lys Ile Leu Ile Glu  Ser Ala Asn Pro Leu  Glu Asn Ala 
    4130                 4135                 4140             


Gly Gln  Asp Ser Ala Val Arg  Ile Glu Glu Gly Lys  Ser Leu Arg 
    4145                 4150                 4155             


Phe Pro  Leu Ala Leu Glu Glu  Lys Gln Val Leu Leu  Lys Glu Glu 
    4160                 4165                 4170             


His Ser  Asp Asn Val Val Met  Pro Pro Asp Gln Ile  Ile Glu Ser 
    4175                 4180                 4185             


Lys Arg  Glu Pro Val Ala Ile  Lys Lys Val Gln Glu  Val Gln Gly 
    4190                 4195                 4200             


Arg Asp  Leu Leu Ser Lys Glu  Ser Leu Leu Ser Gly  Ile Pro Glu 
    4205                 4210                 4215             


Glu Gln  Arg Leu Asn Leu Lys  Ile Gln Ile Cys Arg  Ala Leu Gln 
    4220                 4225                 4230             


Ala Ala  Val Ala Ser Glu Gln  Pro Gly Leu Phe Ser  Glu Trp Leu 
    4235                 4240                 4245             


Arg Asn  Ile Glu Lys Val Glu  Val Glu Ala Val Asn  Ile Thr Gln 
    4250                 4255                 4260             


Glu Pro  Arg His Ile Met Cys  Met Tyr Leu Val Thr  Ser Ala Lys 
    4265                 4270                 4275             


Ser Val  Thr Glu Glu Val Thr  Ile Ile Ile Glu Asp  Val Asp Pro 
    4280                 4285                 4290             


Gln Met  Ala Asn Leu Lys Met  Glu Leu Arg Asp Ala  Leu Cys Ala 
    4295                 4300                 4305             


Ile Ile  Tyr Glu Glu Ile Asp  Ile Leu Thr Ala Glu  Gly Pro Arg 
    4310                 4315                 4320             


Ile Gln  Gln Gly Ala Lys Thr  Ser Leu Gln Glu Glu  Met Asp Ser 
    4325                 4330                 4335             


Phe Ser  Gly Ser Gln Lys Val  Glu Pro Ile Thr Glu  Pro Glu Val 
    4340                 4345                 4350             


Glu Ser  Lys Tyr Leu Ile Ser  Thr Glu Glu Val Ser  Tyr Phe Asn 
    4355                 4360                 4365             


Val Gln  Ser Arg Val Lys Tyr  Leu Asp Ala Thr Pro  Val Thr Lys 
    4370                 4375                 4380             


Gly Val  Ala Ser Ala Val Val  Ser Asp Glu Lys Gln  Asp Glu Ser 
    4385                 4390                 4395             


Leu Lys  Pro Ser Glu Glu Lys  Glu Glu Ser Ser Ser  Glu Ser Gly 
    4400                 4405                 4410             


Thr Glu  Glu Val Ala Thr Val  Lys Ile Gln Glu Ala  Glu Gly Gly 
    4415                 4420                 4425             


Leu Ile  Lys Glu Asp Gly Pro  Met Ile His Thr Pro  Leu Val Asp 
    4430                 4435                 4440             


Thr Val  Ser Glu Glu Gly Asp  Ile Val His Leu Thr  Thr Ser Ile 
    4445                 4450                 4455             


Thr Asn  Ala Lys Glu Val Asn  Trp Tyr Phe Glu Asn  Lys Leu Val 
    4460                 4465                 4470             


Pro Ser  Asp Glu Lys Phe Lys  Cys Leu Gln Asp Gln  Asn Thr Tyr 
    4475                 4480                 4485             


Thr Leu  Val Ile Asp Lys Val  Asn Thr Glu Asp His  Gln Gly Glu 
    4490                 4495                 4500             


Tyr Val  Cys Glu Ala Leu Asn  Asp Ser Gly Lys Thr  Ala Thr Ser 
    4505                 4510                 4515             


Ala Lys  Leu Thr Val Val Lys  Arg Ala Ala Pro Val  Ile Lys Arg 
    4520                 4525                 4530             


Lys Ile  Glu Pro Leu Glu Val  Ala Leu Gly His Leu  Ala Lys Phe 
    4535                 4540                 4545             


Thr Cys  Glu Ile Gln Ser Ala  Pro Asn Val Arg Phe  Gln Trp Phe 
    4550                 4555                 4560             


Lys Ala  Gly Arg Glu Ile Tyr  Glu Ser Asp Lys Cys  Ser Ile Arg 
    4565                 4570                 4575             


Ser Ser  Lys Tyr Ile Ser Ser  Leu Glu Ile Leu Arg  Thr Gln Val 
    4580                 4585                 4590             


Val Asp  Cys Gly Glu Tyr Thr  Cys Lys Ala Ser Asn  Glu Tyr Gly 
    4595                 4600                 4605             


Ser Val  Ser Cys Thr Ala Thr  Leu Thr Val Thr Val  Pro Gly Gly 
    4610                 4615                 4620             


Glu Lys  Lys Val Arg Lys Leu  Leu Pro Glu Arg Lys  Pro Glu Pro 
    4625                 4630                 4635             


Lys Glu  Glu Val Val Leu Lys  Ser Val Leu Arg Lys  Arg Pro Glu 
    4640                 4645                 4650             


Glu Glu  Glu Pro Lys Val Glu  Pro Lys Lys Leu Glu  Lys Val Lys 
    4655                 4660                 4665             


Lys Pro  Ala Val Pro Glu Pro  Pro Pro Pro Lys Pro  Val Glu Glu 
    4670                 4675                 4680             


Val Glu  Val Pro Thr Val Thr  Lys Arg Glu Arg Lys  Ile Pro Glu 
    4685                 4690                 4695             


Pro Thr  Lys Val Pro Glu Ile  Lys Pro Ala Ile Pro  Leu Pro Ala 
    4700                 4705                 4710             


Pro Glu  Pro Lys Pro Lys Pro  Glu Ala Glu Val Lys  Thr Ile Lys 
    4715                 4720                 4725             


Pro Pro  Pro Val Glu Pro Glu  Pro Thr Pro Ile Ala  Ala Pro Val 
    4730                 4735                 4740             


Thr Val  Pro Val Val Gly Lys  Lys Ala Glu Ala Lys  Ala Pro Lys 
    4745                 4750                 4755             


Glu Glu  Ala Ala Lys Pro Lys  Gly Pro Ile Lys Gly  Val Pro Lys 
    4760                 4765                 4770             


Lys Thr  Pro Ser Pro Ile Glu  Ala Glu Arg Arg Lys  Leu Arg Pro 
    4775                 4780                 4785             


Gly Ser  Gly Gly Glu Lys Pro  Pro Asp Glu Ala Pro  Phe Thr Tyr 
    4790                 4795                 4800             


Gln Leu  Lys Ala Val Pro Leu  Lys Phe Val Lys Glu  Ile Lys Asp 
    4805                 4810                 4815             


Ile Ile  Leu Thr Glu Ser Glu  Phe Val Gly Ser Ser  Ala Ile Phe 
    4820                 4825                 4830             


Glu Cys  Leu Val Ser Pro Ser  Thr Ala Ile Thr Thr  Trp Met Lys 
    4835                 4840                 4845             


Asp Gly  Ser Asn Ile Arg Glu  Ser Pro Lys His Arg  Phe Ile Ala 
    4850                 4855                 4860             


Asp Gly  Lys Asp Arg Lys Leu  His Ile Ile Asp Val  Gln Leu Ser 
    4865                 4870                 4875             


Asp Ala  Gly Glu Tyr Thr Cys  Val Leu Arg Leu Gly  Asn Lys Glu 
    4880                 4885                 4890             


Lys Thr  Ser Thr Ala Lys Leu  Val Val Glu Glu Leu  Pro Val Arg 
    4895                 4900                 4905             


Phe Val  Lys Thr Leu Glu Glu  Glu Val Thr Val Val  Lys Gly Gln 
    4910                 4915                 4920             


Pro Leu  Tyr Leu Ser Cys Glu  Leu Asn Lys Glu Arg  Asp Val Val 
    4925                 4930                 4935             


Trp Arg  Lys Asp Gly Lys Ile  Val Val Glu Lys Pro  Gly Arg Ile 
    4940                 4945                 4950             


Val Pro  Gly Val Ile Gly Leu  Met Arg Ala Leu Thr  Ile Asn Asp 
    4955                 4960                 4965             


Ala Asp  Asp Thr Asp Ala Gly  Thr Tyr Thr Val Thr  Val Glu Asn 
    4970                 4975                 4980             


Ala Asn  Asn Leu Glu Cys Ser  Ser Cys Val Lys Val  Val Glu Val 
    4985                 4990                 4995             


Ile Arg  Asp Trp Leu Val Lys  Pro Ile Arg Asp Gln  His Val Lys 
    5000                 5005                 5010             


Pro Lys  Gly Thr Ala Ile Phe  Ala Cys Asp Ile Ala  Lys Asp Thr 
    5015                 5020                 5025             


Pro Asn  Ile Lys Trp Phe Lys  Gly Tyr Asp Glu Ile  Pro Ala Glu 
    5030                 5035                 5040             


Pro Asn  Asp Lys Thr Glu Ile  Leu Arg Asp Gly Asn  His Leu Tyr 
    5045                 5050                 5055             


Leu Lys  Ile Lys Asn Ala Met  Pro Glu Asp Ile Ala  Glu Tyr Ala 
    5060                 5065                 5070             


Val Glu  Ile Glu Gly Lys Arg  Tyr Pro Ala Lys Leu  Thr Leu Gly 
    5075                 5080                 5085             


Glu Arg  Glu Val Glu Leu Leu  Lys Pro Ile Glu Asp  Val Thr Ile 
    5090                 5095                 5100             


Tyr Glu  Lys Glu Ser Ala Ser  Phe Asp Ala Glu Ile  Ser Glu Ala 
    5105                 5110                 5115             


Asp Ile  Pro Gly Gln Trp Lys  Leu Lys Gly Glu Leu  Leu Arg Pro 
    5120                 5125                 5130             


Ser Pro  Thr Cys Glu Ile Lys  Ala Glu Gly Gly Lys  Arg Phe Leu 
    5135                 5140                 5145             


Thr Leu  His Lys Val Lys Leu  Asp Gln Ala Gly Glu  Val Leu Tyr 
    5150                 5155                 5160             


Gln Ala  Leu Asn Ala Ile Thr  Thr Ala Ile Leu Thr  Val Lys Glu 
    5165                 5170                 5175             


Ile Glu  Leu Asp Phe Ala Val  Pro Leu Lys Asp Val  Thr Val Pro 
    5180                 5185                 5190             


Glu Arg  Arg Gln Ala Arg Phe  Glu Cys Val Leu Thr  Arg Glu Ala 
    5195                 5200                 5205             


Asn Val  Ile Trp Ser Lys Gly  Pro Asp Ile Ile Lys  Ser Ser Asp 
    5210                 5215                 5220             


Lys Phe  Asp Ile Ile Ala Asp  Gly Lys Lys His Ile  Leu Val Ile 
    5225                 5230                 5235             


Asn Asp  Ser Gln Phe Asp Asp  Glu Gly Val Tyr Thr  Ala Glu Val 
    5240                 5245                 5250             


Glu Gly  Lys Lys Thr Ser Ala  Arg Leu Phe Val Thr  Gly Ile Arg 
    5255                 5260                 5265             


Leu Lys  Phe Met Ser Pro Leu  Glu Asp Gln Thr Val  Lys Glu Gly 
    5270                 5275                 5280             


Glu Thr  Ala Thr Phe Val Cys  Glu Leu Ser His Glu  Lys Met His 
    5285                 5290                 5295             


Val Val  Trp Phe Lys Asn Asp  Ala Lys Leu His Thr  Ser Arg Thr 
    5300                 5305                 5310             


Val Leu  Ile Ser Ser Glu Gly  Lys Thr His Lys Leu  Glu Met Lys 
    5315                 5320                 5325             


Glu Val  Thr Leu Asp Asp Ile  Ser Gln Ile Lys Ala  Gln Val Lys 
    5330                 5335                 5340             


Glu Leu  Ser Ser Thr Ala Gln  Leu Lys Val Leu Glu  Ala Asp Pro 
    5345                 5350                 5355             


Tyr Phe  Thr Val Lys Leu His  Asp Lys Thr Ala Val  Glu Lys Asp 
    5360                 5365                 5370             


Glu Ile  Thr Leu Lys Cys Glu  Val Ser Lys Asp Val  Pro Val Lys 
    5375                 5380                 5385             


Trp Phe  Lys Asp Gly Glu Glu  Ile Val Pro Ser Pro  Lys Tyr Ser 
    5390                 5395                 5400             


Ile Lys  Ala Asp Gly Leu Arg  Arg Ile Leu Lys Ile  Lys Lys Ala 
    5405                 5410                 5415             


Asp Leu  Lys Asp Lys Gly Glu  Tyr Val Cys Asp Cys  Gly Thr Asp 
    5420                 5425                 5430             


Lys Thr  Lys Ala Asn Val Thr  Val Glu Ala Arg Leu  Ile Lys Val 
    5435                 5440                 5445             


Glu Lys  Pro Leu Tyr Gly Val  Glu Val Phe Val Gly  Glu Thr Ala 
    5450                 5455                 5460             


His Phe  Glu Ile Glu Leu Ser  Glu Pro Asp Val His  Gly Gln Trp 
    5465                 5470                 5475             


Lys Leu  Lys Gly Gln Pro Leu  Thr Ala Ser Pro Asp  Cys Glu Ile 
    5480                 5485                 5490             


Ile Glu  Asp Gly Lys Lys His  Ile Leu Ile Leu His  Asn Cys Gln 
    5495                 5500                 5505             


Leu Gly  Met Thr Gly Glu Val  Ser Phe Gln Ala Ala  Asn Ala Lys 
    5510                 5515                 5520             


Ser Ala  Ala Asn Leu Lys Val  Lys Glu Leu Pro Leu  Ile Phe Ile 
    5525                 5530                 5535             


Thr Pro  Leu Ser Asp Val Lys  Val Phe Glu Lys Asp  Glu Ala Lys 
    5540                 5545                 5550             


Phe Glu  Cys Glu Val Ser Arg  Glu Pro Lys Thr Phe  Arg Trp Leu 
    5555                 5560                 5565             


Lys Gly  Thr Gln Glu Ile Thr  Gly Asp Asp Arg Phe  Glu Leu Ile 
    5570                 5575                 5580             


Lys Asp  Gly Thr Lys His Ser  Met Val Ile Lys Ser  Ala Ala Phe 
    5585                 5590                 5595             


Glu Asp  Glu Ala Lys Tyr Met  Phe Glu Ala Glu Asp  Lys His Thr 
    5600                 5605                 5610             


Ser Gly  Lys Leu Ile Ile Glu  Gly Ile Arg Leu Lys  Phe Leu Thr 
    5615                 5620                 5625             


Pro Leu  Lys Asp Val Thr Ala  Lys Glu Lys Glu Ser  Ala Val Phe 
    5630                 5635                 5640             


Thr Val  Glu Leu Ser His Asp  Asn Ile Arg Val Lys  Trp Phe Lys 
    5645                 5650                 5655             


Asn Asp  Gln Arg Leu His Thr  Thr Arg Ser Val Ser  Met Gln Asp 
    5660                 5665                 5670             


Glu Gly  Lys Thr His Ser Ile  Thr Phe Lys Asp Leu  Ser Ile Asp 
    5675                 5680                 5685             


Asp Thr  Ser Gln Ile Arg Val  Glu Ala Met Gly Met  Ser Ser Glu 
    5690                 5695                 5700             


Ala Lys  Leu Thr Val Leu Glu  Gly Asp Pro Tyr Phe  Thr Gly Lys 
    5705                 5710                 5715             


Leu Gln  Asp Tyr Thr Gly Val  Glu Lys Asp Glu Val  Ile Leu Gln 
    5720                 5725                 5730             


Cys Glu  Ile Ser Lys Ala Asp  Ala Pro Val Lys Trp  Phe Lys Asp 
    5735                 5740                 5745             


Gly Lys  Glu Ile Lys Pro Ser  Lys Asn Ala Val Ile  Lys Ala Asp 
    5750                 5755                 5760             


Gly Lys  Lys Arg Met Leu Ile  Leu Lys Lys Ala Leu  Lys Ser Asp 
    5765                 5770                 5775             


Ile Gly  Gln Tyr Thr Cys Asp  Cys Gly Thr Asp Lys  Thr Ser Gly 
    5780                 5785                 5790             


Lys Leu  Asp Ile Glu Asp Arg  Glu Ile Lys Leu Val  Arg Pro Leu 
    5795                 5800                 5805             


His Ser  Val Glu Val Met Glu  Thr Glu Thr Ala Arg  Phe Glu Thr 
    5810                 5815                 5820             


Glu Ile  Ser Glu Asp Asp Ile  His Ala Asn Trp Lys  Leu Lys Gly 
    5825                 5830                 5835             


Glu Ala  Leu Leu Gln Thr Pro  Asp Cys Glu Ile Lys  Glu Glu Gly 
    5840                 5845                 5850             


Lys Ile  His Ser Leu Val Leu  His Asn Cys Arg Leu  Asp Gln Thr 
    5855                 5860                 5865             


Gly Gly  Val Asp Phe Gln Ala  Ala Asn Val Lys Ser  Ser Ala His 
    5870                 5875                 5880             


Leu Arg  Val Lys Pro Arg Val  Ile Gly Leu Leu Arg  Pro Leu Lys 
    5885                 5890                 5895             


Asp Val  Thr Val Thr Ala Gly  Glu Thr Ala Thr Phe  Asp Cys Glu 
    5900                 5905                 5910             


Leu Ser  Tyr Glu Asp Ile Pro  Val Glu Trp Tyr Leu  Lys Gly Lys 
    5915                 5920                 5925             


Lys Leu  Glu Pro Ser Asp Lys  Val Val Pro Arg Ser  Glu Gly Lys 
    5930                 5935                 5940             


Val His  Thr Leu Thr Leu Arg  Asp Val Lys Leu Glu  Asp Ala Gly 
    5945                 5950                 5955             


Glu Val  Gln Leu Thr Ala Lys  Asp Phe Lys Thr His  Ala Asn Leu 
    5960                 5965                 5970             


Phe Val  Lys Glu Pro Pro Val  Glu Phe Thr Lys Pro  Leu Glu Asp 
    5975                 5980                 5985             


Gln Thr  Val Glu Glu Gly Ala  Thr Ala Val Leu Glu  Cys Glu Val 
    5990                 5995                 6000             


Ser Arg  Glu Asn Ala Lys Val  Lys Trp Phe Lys Asn  Gly Thr Glu 
    6005                 6010                 6015             


Ile Leu  Lys Ser Lys Lys Tyr  Glu Ile Val Ala Asp  Gly Arg Val 
    6020                 6025                 6030             


Arg Lys  Leu Val Ile His Asp  Cys Thr Pro Glu Asp  Ile Lys Thr 
    6035                 6040                 6045             


Tyr Thr  Cys Asp Ala Lys Asp  Phe Lys Thr Ser Cys  Asn Leu Asn 
    6050                 6055                 6060             


Val Val  Pro Pro His Val Glu  Phe Leu Arg Pro Leu  Thr Asp Leu 
    6065                 6070                 6075             


Gln Val  Arg Glu Lys Glu Met  Ala Arg Phe Glu Cys  Glu Leu Ser 
    6080                 6085                 6090             


Arg Glu  Asn Ala Lys Val Lys  Trp Phe Lys Asp Gly  Ala Glu Ile 
    6095                 6100                 6105             


Lys Lys  Gly Lys Lys Tyr Asp  Ile Ile Ser Lys Gly  Ala Val Arg 
    6110                 6115                 6120             


Ile Leu  Val Ile Asn Lys Cys  Leu Leu Asp Asp Glu  Ala Glu Tyr 
    6125                 6130                 6135             


Ser Cys  Glu Val Arg Thr Ala  Arg Thr Ser Gly Met  Leu Thr Val 
    6140                 6145                 6150             


Leu Glu  Glu Glu Ala Val Phe  Thr Lys Asn Leu Ala  Asn Ile Glu 
    6155                 6160                 6165             


Val Ser  Glu Thr Asp Thr Ile  Lys Leu Val Cys Glu  Val Ser Lys 
    6170                 6175                 6180             


Pro Gly  Ala Glu Val Ile Trp  Tyr Lys Gly Asp Glu  Glu Ile Ile 
    6185                 6190                 6195             


Glu Thr  Gly Arg Tyr Glu Ile  Leu Thr Glu Gly Arg  Lys Arg Ile 
    6200                 6205                 6210             


Leu Val  Ile Gln Asn Ala His  Leu Glu Asp Ala Gly  Asn Tyr Asn 
    6215                 6220                 6225             


Cys Arg  Leu Pro Ser Ser Arg  Thr Asp Gly Lys Val  Lys Val His 
    6230                 6235                 6240             


Glu Leu  Ala Ala Glu Phe Ile  Ser Lys Pro Gln Asn  Leu Glu Ile 
    6245                 6250                 6255             


Leu Glu  Gly Glu Lys Ala Glu  Phe Val Cys Ser Ile  Ser Lys Glu 
    6260                 6265                 6270             


Ser Phe  Pro Val Gln Trp Lys  Arg Asp Asp Lys Thr  Leu Glu Ser 
    6275                 6280                 6285             


Gly Asp  Lys Tyr Asp Val Ile  Ala Asp Gly Lys Lys  Arg Val Leu 
    6290                 6295                 6300             


Val Val  Lys Asp Ala Thr Leu  Gln Asp Met Gly Thr  Tyr Val Val 
    6305                 6310                 6315             


Met Val  Gly Ala Ala Arg Ala  Ala Ala His Leu Thr  Val Ile Glu 
    6320                 6325                 6330             


Lys Leu  Arg Ile Val Val Pro  Leu Lys Asp Thr Arg  Val Lys Glu 
    6335                 6340                 6345             


Gln Gln  Glu Val Val Phe Asn  Cys Glu Val Asn Thr  Glu Gly Ala 
    6350                 6355                 6360             


Lys Ala  Lys Trp Phe Arg Asn  Glu Glu Ala Ile Phe  Asp Ser Ser 
    6365                 6370                 6375             


Lys Tyr  Ile Ile Leu Gln Lys  Asp Leu Val Tyr Thr  Leu Arg Ile 
    6380                 6385                 6390             


Arg Asp  Ala His Leu Asp Asp  Gln Ala Asn Tyr Asn  Val Ser Leu 
    6395                 6400                 6405             


Thr Asn  His Arg Gly Glu Asn  Val Lys Ser Ala Ala  Asn Leu Ile 
    6410                 6415                 6420             


Val Glu  Glu Glu Asp Leu Arg  Ile Val Glu Pro Leu  Lys Asp Ile 
    6425                 6430                 6435             


Glu Thr  Met Glu Lys Lys Ser  Val Thr Phe Trp Cys  Lys Val Asn 
    6440                 6445                 6450             


Arg Leu  Asn Val Thr Leu Lys  Trp Thr Lys Asn Gly  Glu Glu Val 
    6455                 6460                 6465             


Pro Phe  Asp Asn Arg Val Ser  Tyr Arg Val Asp Lys  Tyr Lys His 
    6470                 6475                 6480             


Met Leu  Thr Ile Lys Asp Cys  Gly Phe Pro Asp Glu  Gly Glu Tyr 
    6485                 6490                 6495             


Ile Val  Thr Ala Gly Gln Asp  Lys Ser Val Ala Glu  Leu Leu Ile 
    6500                 6505                 6510             


Ile Glu  Ala Pro Thr Glu Phe  Val Glu His Leu Glu  Asp Gln Thr 
    6515                 6520                 6525             


Val Thr  Glu Phe Asp Asp Ala  Val Phe Ser Cys Gln  Leu Ser Arg 
    6530                 6535                 6540             


Glu Lys  Ala Asn Val Lys Trp  Tyr Arg Asn Gly Arg  Glu Ile Lys 
    6545                 6550                 6555             


Glu Gly  Lys Lys Tyr Lys Phe  Glu Lys Asp Gly Ser  Ile His Arg 
    6560                 6565                 6570             


Leu Ile  Ile Lys Asp Cys Arg  Leu Asp Asp Glu Cys  Glu Tyr Ala 
    6575                 6580                 6585             


Cys Gly  Val Glu Asp Arg Lys  Ser Arg Ala Arg Leu  Phe Val Glu 
    6590                 6595                 6600             


Glu Ile  Pro Val Glu Ile Ile  Arg Pro Pro Gln Asp  Ile Leu Glu 
    6605                 6610                 6615             


Ala Pro  Gly Ala Asp Val Val  Phe Leu Ala Glu Leu  Asn Lys Asp 
    6620                 6625                 6630             


Lys Val  Glu Val Gln Trp Leu  Arg Asn Asn Met Val  Val Val Gln 
    6635                 6640                 6645             


Gly Asp  Lys His Gln Met Met  Ser Glu Gly Lys Ile  His Arg Leu 
    6650                 6655                 6660             


Gln Ile  Cys Asp Ile Lys Pro  Arg Asp Gln Gly Glu  Tyr Arg Phe 
    6665                 6670                 6675             


Ile Ala  Lys Asp Lys Glu Ala  Arg Ala Lys Leu Glu  Leu Ala Ala 
    6680                 6685                 6690             


Ala Pro  Lys Ile Lys Thr Ala  Asp Gln Asp Leu Val  Val Asp Val 
    6695                 6700                 6705             


Gly Lys  Pro Leu Thr Met Val  Val Pro Tyr Asp Ala  Tyr Pro Lys 
    6710                 6715                 6720             


Ala Glu  Ala Glu Trp Phe Lys  Glu Asn Glu Pro Leu  Ser Thr Lys 
    6725                 6730                 6735             


Thr Ile  Asp Thr Thr Ala Glu  Gln Thr Ser Phe Arg  Ile Leu Glu 
    6740                 6745                 6750             


Ala Lys  Lys Gly Asp Lys Gly  Arg Tyr Lys Ile Val  Leu Gln Asn 
    6755                 6760                 6765             


Lys His  Gly Lys Ala Glu Gly  Phe Ile Asn Leu Lys  Val Ile Asp 
    6770                 6775                 6780             


Val Pro  Gly Pro Val Arg Asn  Leu Glu Val Thr Glu  Thr Phe Asp 
    6785                 6790                 6795             


Gly Glu  Val Ser Leu Ala Trp  Glu Glu Pro Leu Thr  Asp Gly Gly 
    6800                 6805                 6810             


Ser Lys  Ile Ile Gly Tyr Val  Val Glu Arg Arg Asp  Ile Lys Arg 
    6815                 6820                 6825             


Lys Thr  Trp Val Leu Ala Thr  Asp Arg Ala Glu Ser  Cys Glu Phe 
    6830                 6835                 6840             


Thr Val  Thr Gly Leu Gln Lys  Gly Gly Val Glu Tyr  Leu Phe Arg 
    6845                 6850                 6855             


Val Ser  Ala Arg Asn Arg Val  Gly Thr Gly Glu Pro  Val Glu Thr 
    6860                 6865                 6870             


Asp Asn  Pro Val Glu Ala Arg  Ser Lys Tyr Asp Val  Pro Gly Pro 
    6875                 6880                 6885             


Pro Leu  Asn Val Thr Ile Thr  Asp Val Asn Arg Phe  Gly Val Ser 
    6890                 6895                 6900             


Leu Thr  Trp Glu Pro Pro Glu  Tyr Asp Gly Gly Ala  Glu Ile Thr 
    6905                 6910                 6915             


Asn Tyr  Val Ile Glu Leu Arg  Asp Lys Thr Ser Ile  Arg Trp Asp 
    6920                 6925                 6930             


Thr Ala  Met Thr Val Arg Ala  Glu Asp Leu Ser Ala  Thr Val Thr 
    6935                 6940                 6945             


Asp Val  Val Glu Gly Gln Glu  Tyr Ser Phe Arg Val  Arg Ala Gln 
    6950                 6955                 6960             


Asn Arg  Ile Gly Val Gly Lys  Pro Ser Ala Ala Thr  Pro Phe Val 
    6965                 6970                 6975             


Lys Val  Ala Asp Pro Ile Glu  Arg Pro Ser Pro Pro  Val Asn Leu 
    6980                 6985                 6990             


Thr Ser  Ser Asp Gln Thr Gln  Ser Ser Val Gln Leu  Lys Trp Glu 
    6995                 7000                 7005             


Pro Pro  Leu Lys Asp Gly Gly  Ser Pro Ile Leu Gly  Tyr Ile Ile 
    7010                 7015                 7020             


Glu Arg  Cys Glu Glu Gly Lys  Asp Asn Trp Ile Arg  Cys Asn Met 
    7025                 7030                 7035             


Lys Leu  Val Pro Glu Leu Thr  Tyr Lys Val Thr Gly  Leu Glu Lys 
    7040                 7045                 7050             


Gly Asn  Lys Tyr Leu Tyr Arg  Val Ser Ala Glu Asn  Lys Ala Gly 
    7055                 7060                 7065             


Val Ser  Asp Pro Ser Glu Ile  Leu Gly Pro Leu Thr  Ala Asp Asp 
    7070                 7075                 7080             


Ala Phe  Val Glu Pro Thr Met  Asp Leu Ser Ala Phe  Lys Asp Gly 
    7085                 7090                 7095             


Leu Glu  Val Ile Val Pro Asn  Pro Ile Thr Ile Leu  Val Pro Ser 
    7100                 7105                 7110             


Thr Gly  Tyr Pro Arg Pro Thr  Ala Thr Trp Cys Phe  Gly Asp Lys 
    7115                 7120                 7125             


Val Leu  Glu Thr Gly Asp Arg  Val Lys Met Lys Thr  Leu Ser Ala 
    7130                 7135                 7140             


Tyr Ala  Glu Leu Val Ile Ser  Pro Ser Glu Arg Ser  Asp Lys Gly 
    7145                 7150                 7155             


Ile Tyr  Thr Leu Lys Leu Glu  Asn Arg Val Lys Thr  Ile Ser Gly 
    7160                 7165                 7170             


Glu Ile  Asp Val Asn Val Ile  Ala Arg Pro Ser Ala  Pro Lys Glu 
    7175                 7180                 7185             


Leu Lys  Phe Gly Asp Ile Thr  Lys Asp Ser Val His  Leu Thr Trp 
    7190                 7195                 7200             


Glu Pro  Pro Asp Asp Asp Gly  Gly Ser Pro Leu Thr  Gly Tyr Val 
    7205                 7210                 7215             


Val Glu  Lys Arg Glu Val Ser  Arg Lys Thr Trp Thr  Lys Val Met 
    7220                 7225                 7230             


Asp Phe  Val Thr Asp Leu Glu  Phe Thr Val Pro Asp  Leu Val Gln 
    7235                 7240                 7245             


Gly Lys  Glu Tyr Leu Phe Lys  Val Cys Ala Arg Asn  Lys Cys Gly 
    7250                 7255                 7260             


Pro Gly  Glu Pro Ala Tyr Val  Asp Glu Pro Val Asn  Met Ser Thr 
    7265                 7270                 7275             


Pro Ala  Thr Val Pro Asp Pro  Pro Glu Asn Val Lys  Trp Arg Asp 
    7280                 7285                 7290             


Arg Thr  Ala Asn Ser Ile Phe  Leu Thr Trp Asp Pro  Pro Lys Asn 
    7295                 7300                 7305             


Asp Gly  Gly Ser Arg Ile Lys  Gly Tyr Ile Val Glu  Arg Cys Pro 
    7310                 7315                 7320             


Arg Gly  Ser Asp Lys Trp Val  Ala Cys Gly Glu Pro  Val Ala Glu 
    7325                 7330                 7335             


Thr Lys  Met Glu Val Thr Gly  Leu Glu Glu Gly Lys  Trp Tyr Ala 
    7340                 7345                 7350             


Tyr Arg  Val Lys Ala Leu Asn  Arg Gln Gly Ala Ser  Lys Pro Ser 
    7355                 7360                 7365             


Arg Pro  Thr Glu Glu Ile Gln  Ala Val Asp Thr Gln  Glu Ala Pro 
    7370                 7375                 7380             


Glu Ile  Phe Leu Asp Val Lys  Leu Leu Ala Gly Leu  Thr Val Lys 
    7385                 7390                 7395             


Ala Gly  Thr Lys Ile Glu Leu  Pro Ala Thr Val Thr  Gly Lys Pro 
    7400                 7405                 7410             


Glu Pro  Lys Ile Thr Trp Thr  Lys Ala Asp Met Ile  Leu Lys Gln 
    7415                 7420                 7425             


Asp Lys  Arg Ile Thr Ile Glu  Asn Val Pro Lys Lys  Ser Thr Val 
    7430                 7435                 7440             


Thr Ile  Val Asp Ser Lys Arg  Ser Asp Thr Gly Thr  Tyr Ile Ile 
    7445                 7450                 7455             


Glu Ala  Val Asn Val Cys Gly  Arg Ala Thr Ala Val  Val Glu Val 
    7460                 7465                 7470             


Asn Val  Leu Asp Lys Pro Gly  Pro Pro Ala Ala Phe  Asp Ile Thr 
    7475                 7480                 7485             


Asp Val  Thr Asn Glu Ser Cys  Leu Leu Thr Trp Asn  Pro Pro Arg 
    7490                 7495                 7500             


Asp Asp  Gly Gly Ser Lys Ile  Thr Asn Tyr Val Val  Glu Arg Arg 
    7505                 7510                 7515             


Ala Thr  Asp Ser Glu Val Trp  His Lys Leu Ser Ser  Thr Val Lys 
    7520                 7525                 7530             


Asp Thr  Asn Phe Lys Ala Thr  Lys Leu Ile Pro Asn  Lys Glu Tyr 
    7535                 7540                 7545             


Ile Phe  Arg Val Ala Ala Glu  Asn Met Tyr Gly Val  Gly Glu Pro 
    7550                 7555                 7560             


Val Gln  Ala Ser Pro Ile Thr  Ala Lys Tyr Gln Phe  Asp Pro Pro 
    7565                 7570                 7575             


Gly Pro  Pro Thr Arg Leu Glu  Pro Ser Asp Ile Thr  Lys Asp Ala 
    7580                 7585                 7590             


Val Thr  Leu Thr Trp Cys Glu  Pro Asp Asp Asp Gly  Gly Ser Pro 
    7595                 7600                 7605             


Ile Thr  Gly Tyr Trp Val Glu  Arg Leu Asp Pro Asp  Thr Asp Lys 
    7610                 7615                 7620             


Trp Val  Arg Cys Asn Lys Met  Pro Val Lys Asp Thr  Thr Tyr Arg 
    7625                 7630                 7635             


Val Lys  Gly Leu Thr Asn Lys  Lys Lys Tyr Arg Phe  Arg Val Leu 
    7640                 7645                 7650             


Ala Glu  Asn Leu Ala Gly Pro  Gly Lys Pro Ser Lys  Ser Thr Glu 
    7655                 7660                 7665             


Pro Ile  Leu Ile Lys Asp Pro  Ile Asp Pro Pro Trp  Pro Pro Gly 
    7670                 7675                 7680             


Lys Pro  Thr Val Lys Asp Val  Gly Lys Thr Ser Val  Arg Leu Asn 
    7685                 7690                 7695             


Trp Thr  Lys Pro Glu His Asp  Gly Gly Ala Lys Ile  Glu Ser Tyr 
    7700                 7705                 7710             


Val Ile  Glu Met Leu Lys Thr  Gly Thr Asp Glu Trp  Val Arg Val 
    7715                 7720                 7725             


Ala Glu  Gly Val Pro Thr Thr  Gln His Leu Leu Pro  Gly Leu Met 
    7730                 7735                 7740             


Glu Gly  Gln Glu Tyr Ser Phe  Arg Val Arg Ala Val  Asn Lys Ala 
    7745                 7750                 7755             


Gly Glu  Ser Glu Pro Ser Glu  Pro Ser Asp Pro Val  Leu Cys Arg 
    7760                 7765                 7770             


Glu Lys  Leu Tyr Pro Pro Ser  Pro Pro Arg Trp Leu  Glu Val Ile 
    7775                 7780                 7785             


Asn Ile  Thr Lys Asn Thr Ala  Asp Leu Lys Trp Thr  Val Pro Glu 
    7790                 7795                 7800             


Lys Asp  Gly Gly Ser Pro Ile  Thr Asn Tyr Ile Val  Glu Lys Arg 
    7805                 7810                 7815             


Asp Val  Arg Arg Lys Gly Trp  Gln Thr Val Asp Thr  Thr Val Lys 
    7820                 7825                 7830             


Asp Thr  Lys Cys Thr Val Thr  Pro Leu Thr Glu Gly  Ser Leu Tyr 
    7835                 7840                 7845             


Val Phe  Arg Val Ala Ala Glu  Asn Ala Ile Gly Gln  Ser Asp Tyr 
    7850                 7855                 7860             


Thr Glu  Ile Glu Asp Ser Val  Leu Ala Lys Asp Thr  Phe Thr Thr 
    7865                 7870                 7875             


Pro Gly  Pro Pro Tyr Ala Leu  Ala Val Val Asp Val  Thr Lys Arg 
    7880                 7885                 7890             


His Val  Asp Leu Lys Trp Glu  Pro Pro Lys Asn Asp  Gly Gly Arg 
    7895                 7900                 7905             


Pro Ile  Gln Arg Tyr Val Ile  Glu Lys Lys Glu Arg  Leu Gly Thr 
    7910                 7915                 7920             


Arg Trp  Val Lys Ala Gly Lys  Thr Ala Gly Pro Asp  Cys Asn Phe 
    7925                 7930                 7935             


Arg Val  Thr Asp Val Ile Glu  Gly Thr Glu Val Gln  Phe Gln Val 
    7940                 7945                 7950             


Arg Ala  Glu Asn Glu Ala Gly  Val Gly His Pro Ser  Glu Pro Thr 
    7955                 7960                 7965             


Glu Ile  Leu Ser Ile Glu Asp  Pro Thr Ser Pro Pro  Ser Pro Pro 
    7970                 7975                 7980             


Leu Asp  Leu His Val Thr Asp  Ala Gly Arg Lys His  Ile Ala Ile 
    7985                 7990                 7995             


Ala Trp  Lys Pro Pro Glu Lys  Asn Gly Gly Ser Pro  Ile Ile Gly 
    8000                 8005                 8010             


Tyr His  Val Glu Met Cys Pro  Val Gly Thr Glu Lys  Trp Met Arg 
    8015                 8020                 8025             


Val Asn  Ser Arg Pro Ile Lys  Asp Leu Lys Phe Lys  Val Glu Glu 
    8030                 8035                 8040             


Gly Val  Val Pro Asp Lys Glu  Tyr Val Leu Arg Val  Arg Ala Val 
    8045                 8050                 8055             


Asn Ala  Ile Gly Val Ser Glu  Pro Ser Glu Ile Ser  Glu Asn Val 
    8060                 8065                 8070             


Val Ala  Lys Asp Pro Asp Cys  Lys Pro Thr Ile Asp  Leu Glu Thr 
    8075                 8080                 8085             


His Asp  Ile Ile Val Ile Glu  Gly Glu Lys Leu Ser  Ile Pro Val 
    8090                 8095                 8100             


Pro Phe  Arg Ala Val Pro Val  Pro Thr Val Ser Trp  His Lys Asp 
    8105                 8110                 8115             


Gly Lys  Glu Val Lys Ala Ser  Asp Arg Leu Thr Met  Lys Asn Asp 
    8120                 8125                 8130             


His Ile  Ser Ala His Leu Glu  Val Pro Lys Ser Val  Arg Ala Asp 
    8135                 8140                 8145             


Ala Gly  Ile Tyr Thr Ile Thr  Leu Glu Asn Lys Leu  Gly Ser Ala 
    8150                 8155                 8160             


Thr Ala  Ser Ile Asn Val Lys  Val Ile Gly Leu Pro  Gly Pro Cys 
    8165                 8170                 8175             


Lys Asp  Ile Lys Ala Ser Asp  Ile Thr Lys Ser Ser  Cys Lys Leu 
    8180                 8185                 8190             


Thr Trp  Glu Pro Pro Glu Phe  Asp Gly Gly Thr Pro  Ile Leu His 
    8195                 8200                 8205             


Tyr Val  Leu Glu Arg Arg Glu  Ala Gly Arg Arg Thr  Tyr Ile Pro 
    8210                 8215                 8220             


Val Met  Ser Gly Glu Asn Lys  Leu Ser Trp Thr Val  Lys Asp Leu 
    8225                 8230                 8235             


Ile Pro  Asn Gly Glu Tyr Phe  Phe Arg Val Lys Ala  Val Asn Lys 
    8240                 8245                 8250             


Val Gly  Gly Gly Glu Tyr Ile  Glu Leu Lys Asn Pro  Val Ile Ala 
    8255                 8260                 8265             


Gln Asp  Pro Lys Gln Pro Pro  Asp Pro Pro Val Asp  Val Glu Val 
    8270                 8275                 8280             


His Asn  Pro Thr Ala Glu Ala  Met Thr Ile Thr Trp  Lys Pro Pro 
    8285                 8290                 8295             


Leu Tyr  Asp Gly Gly Ser Lys  Ile Met Gly Tyr Ile  Ile Glu Lys 
    8300                 8305                 8310             


Ile Ala  Lys Gly Glu Glu Arg  Trp Lys Arg Cys Asn  Glu His Leu 
    8315                 8320                 8325             


Val Pro  Ile Leu Thr Tyr Thr  Ala Lys Gly Leu Glu  Glu Gly Lys 
    8330                 8335                 8340             


Glu Tyr  Gln Phe Arg Val Arg  Ala Glu Asn Ala Ala  Gly Ile Ser 
    8345                 8350                 8355             


Glu Pro  Ser Arg Ala Thr Pro  Pro Thr Lys Ala Val  Asp Pro Ile 
    8360                 8365                 8370             


Asp Ala  Pro Lys Val Ile Leu  Arg Thr Ser Leu Glu  Val Lys Arg 
    8375                 8380                 8385             


Gly Asp  Glu Ile Ala Leu Asp  Ala Ser Ile Ser Gly  Ser Pro Tyr 
    8390                 8395                 8400             


Pro Thr  Ile Thr Trp Ile Lys  Asp Glu Asn Val Ile  Val Pro Glu 
    8405                 8410                 8415             


Glu Ile  Lys Lys Arg Ala Ala  Pro Leu Val Arg Arg  Arg Lys Gly 
    8420                 8425                 8430             


Glu Val  Gln Glu Glu Glu Pro  Phe Val Leu Pro Leu  Thr Gln Arg 
    8435                 8440                 8445             


Leu Ser  Ile Asp Asn Ser Lys  Lys Gly Glu Ser Gln  Leu Arg Val 
    8450                 8455                 8460             


Arg Asp  Ser Leu Arg Pro Asp  His Gly Leu Tyr Met  Ile Lys Val 
    8465                 8470                 8475             


Glu Asn  Asp His Gly Ile Ala  Lys Ala Pro Cys Thr  Val Ser Val 
    8480                 8485                 8490             


Leu Asp  Thr Pro Gly Pro Pro  Ile Asn Phe Val Phe  Glu Asp Ile 
    8495                 8500                 8505             


Arg Lys  Thr Ser Val Leu Cys  Lys Trp Glu Pro Pro  Leu Asp Asp 
    8510                 8515                 8520             


Gly Gly  Ser Glu Ile Ile Asn  Tyr Thr Leu Glu Lys  Lys Asp Lys 
    8525                 8530                 8535             


Thr Lys  Pro Asp Ser Glu Trp  Ile Val Val Thr Ser  Thr Leu Arg 
    8540                 8545                 8550             


His Cys  Lys Tyr Ser Val Thr  Lys Leu Ile Glu Gly  Lys Glu Tyr 
    8555                 8560                 8565             


Leu Phe  Arg Val Arg Ala Glu  Asn Arg Phe Gly Pro  Gly Pro Pro 
    8570                 8575                 8580             


Cys Val  Ser Lys Pro Leu Val  Ala Lys Asp Pro Phe  Gly Pro Pro 
    8585                 8590                 8595             


Asp Ala  Pro Asp Lys Pro Ile  Val Glu Asp Val Thr  Ser Asn Ser 
    8600                 8605                 8610             


Met Leu  Val Lys Trp Asn Glu  Pro Lys Asp Asn Gly  Ser Pro Ile 
    8615                 8620                 8625             


Leu Gly  Tyr Trp Leu Glu Lys  Arg Glu Val Asn Ser  Thr His Trp 
    8630                 8635                 8640             


Ser Arg  Val Asn Lys Ser Leu  Leu Asn Ala Leu Lys  Ala Asn Val 
    8645                 8650                 8655             


Asp Gly  Leu Leu Glu Gly Leu  Thr Tyr Val Phe Arg  Val Cys Ala 
    8660                 8665                 8670             


Glu Asn  Ala Ala Gly Pro Gly  Lys Phe Ser Pro Pro  Ser Asp Pro 
    8675                 8680                 8685             


Lys Thr  Ala His Asp Pro Ile  Ser Pro Pro Gly Pro  Pro Ile Pro 
    8690                 8695                 8700             


Arg Val  Thr Asp Thr Ser Ser  Thr Thr Ile Glu Leu  Glu Trp Glu 
    8705                 8710                 8715             


Pro Pro  Ala Phe Asn Gly Gly  Gly Glu Ile Val Gly  Tyr Phe Val 
    8720                 8725                 8730             


Asp Lys  Gln Leu Val Gly Thr  Asn Glu Trp Ser Arg  Cys Thr Glu 
    8735                 8740                 8745             


Lys Met  Ile Lys Val Arg Gln  Tyr Thr Val Lys Glu  Ile Arg Glu 
    8750                 8755                 8760             


Gly Ala  Asp Tyr Lys Leu Arg  Val Ser Ala Val Asn  Ala Ala Gly 
    8765                 8770                 8775             


Glu Gly  Pro Pro Gly Glu Thr  Gln Pro Val Thr Val  Ala Glu Pro 
    8780                 8785                 8790             


Gln Glu  Pro Pro Ala Val Glu  Leu Asp Val Ser Val  Lys Gly Gly 
    8795                 8800                 8805             


Ile Gln  Ile Met Ala Gly Lys  Thr Leu Arg Ile Pro  Ala Val Val 
    8810                 8815                 8820             


Thr Gly  Arg Pro Val Pro Thr  Lys Val Trp Thr Lys  Glu Glu Gly 
    8825                 8830                 8835             


Glu Leu  Asp Lys Asp Arg Val  Val Ile Asp Asn Val  Gly Thr Lys 
    8840                 8845                 8850             


Ser Glu  Leu Ile Ile Lys Asp  Ala Leu Arg Lys Asp  His Gly Arg 
    8855                 8860                 8865             


Tyr Val  Ile Thr Ala Thr Asn  Ser Cys Gly Ser Lys  Phe Ala Ala 
    8870                 8875                 8880             


Ala Arg  Val Glu Val Phe Asp  Val Pro Gly Pro Val  Leu Asp Leu 
    8885                 8890                 8895             


Lys Pro  Val Val Thr Asn Arg  Lys Met Cys Leu Leu  Asn Trp Ser 
    8900                 8905                 8910             


Asp Pro  Glu Asp Asp Gly Gly  Ser Glu Ile Thr Gly  Phe Ile Ile 
    8915                 8920                 8925             


Glu Arg  Lys Asp Ala Lys Met  His Thr Trp Arg Gln  Pro Ile Glu 
    8930                 8935                 8940             


Thr Glu  Arg Ser Lys Cys Asp  Ile Thr Gly Leu Leu  Glu Gly Gln 
    8945                 8950                 8955             


Glu Tyr  Lys Phe Arg Val Ile  Ala Lys Asn Lys Phe  Gly Cys Gly 
    8960                 8965                 8970             


Pro Pro  Val Glu Ile Gly Pro  Ile Leu Ala Val Asp  Pro Leu Gly 
    8975                 8980                 8985             


Pro Pro  Thr Ser Pro Glu Arg  Leu Thr Tyr Thr Glu  Arg Thr Lys 
    8990                 8995                 9000             


Ser Thr  Ile Thr Leu Asp Trp  Lys Glu Pro Arg Ser  Asn Gly Gly 
    9005                 9010                 9015             


Ser Pro  Ile Gln Gly Tyr Ile  Ile Glu Lys Arg Arg  His Asp Lys 
    9020                 9025                 9030             


Pro Asp  Phe Glu Arg Val Asn  Lys Arg Leu Cys Pro  Thr Thr Ser 
    9035                 9040                 9045             


Phe Leu  Val Glu Asn Leu Asp  Glu His Gln Met Tyr  Glu Phe Arg 
    9050                 9055                 9060             


Val Lys  Ala Val Asn Glu Ile  Gly Glu Ser Glu Pro  Ser Leu Pro 
    9065                 9070                 9075             


Leu Asn  Val Val Ile Gln Asp  Asp Glu Val Pro Pro  Thr Ile Lys 
    9080                 9085                 9090             


Leu Arg  Leu Ser Val Arg Gly  Asp Thr Ile Lys Val  Lys Ala Gly 
    9095                 9100                 9105             


Glu Pro  Val His Ile Pro Ala  Asp Val Thr Gly Leu  Pro Met Pro 
    9110                 9115                 9120             


Lys Ile  Glu Trp Ser Lys Asn  Glu Thr Val Ile Glu  Lys Pro Thr 
    9125                 9130                 9135             


Asp Ala  Leu Gln Ile Thr Lys  Glu Glu Val Ser Arg  Ser Glu Ala 
    9140                 9145                 9150             


Lys Thr  Glu Leu Ser Ile Pro  Lys Ala Val Arg Glu  Asp Lys Gly 
    9155                 9160                 9165             


Thr Tyr  Thr Val Thr Ala Ser  Asn Arg Leu Gly Ser  Val Phe Arg 
    9170                 9175                 9180             


Asn Val  His Val Glu Val Tyr  Asp Arg Pro Ser Pro  Pro Arg Asn 
    9185                 9190                 9195             


Leu Ala  Val Thr Asp Ile Lys  Ala Glu Ser Cys Tyr  Leu Thr Trp 
    9200                 9205                 9210             


Asp Ala  Pro Leu Asp Asn Gly  Gly Ser Glu Ile Thr  His Tyr Val 
    9215                 9220                 9225             


Ile Asp  Lys Arg Asp Ala Ser  Arg Lys Lys Ala Glu  Trp Glu Glu 
    9230                 9235                 9240             


Val Thr  Asn Thr Ala Val Glu  Lys Arg Tyr Gly Ile  Trp Lys Leu 
    9245                 9250                 9255             


Ile Pro  Asn Gly Gln Tyr Glu  Phe Arg Val Arg Ala  Val Asn Lys 
    9260                 9265                 9270             


Tyr Gly  Ile Ser Asp Glu Cys  Lys Ser Asp Lys Val  Val Ile Gln 
    9275                 9280                 9285             


Asp Pro  Tyr Arg Leu Pro Gly  Pro Pro Gly Lys Pro  Lys Val Leu 
    9290                 9295                 9300             


Ala Arg  Thr Lys Gly Ser Met  Leu Val Ser Trp Thr  Pro Pro Leu 
    9305                 9310                 9315             


Asp Asn  Gly Gly Ser Pro Ile  Thr Gly Tyr Trp Leu  Glu Lys Arg 
    9320                 9325                 9330             


Glu Glu  Gly Ser Pro Tyr Trp  Ser Arg Val Ser Arg  Ala Pro Ile 
    9335                 9340                 9345             


Thr Lys  Val Gly Leu Lys Gly  Val Glu Phe Asn Val  Pro Arg Leu 
    9350                 9355                 9360             


Leu Glu  Gly Val Lys Tyr Gln  Phe Arg Ala Met Ala  Ile Asn Ala 
    9365                 9370                 9375             


Ala Gly  Ile Gly Pro Pro Ser  Glu Pro Ser Asp Pro  Glu Val Ala 
    9380                 9385                 9390             


Gly Asp  Pro Ile Phe Pro Pro  Gly Pro Pro Ser Cys  Pro Glu Val 
    9395                 9400                 9405             


Lys Asp  Lys Thr Lys Ser Ser  Ile Ser Leu Gly Trp  Lys Pro Pro 
    9410                 9415                 9420             


Ala Lys  Asp Gly Gly Ser Pro  Ile Lys Gly Tyr Ile  Val Glu Met 
    9425                 9430                 9435             


Gln Glu  Glu Gly Thr Thr Asp  Trp Lys Arg Val Asn  Glu Pro Asp 
    9440                 9445                 9450             


Lys Leu  Ile Thr Thr Cys Glu  Cys Val Val Pro Asn  Leu Lys Glu 
    9455                 9460                 9465             


Leu Arg  Lys Tyr Arg Phe Arg  Val Lys Ala Val Asn  Glu Ala Gly 
    9470                 9475                 9480             


Glu Ser  Glu Pro Ser Asp Thr  Thr Gly Glu Ile Pro  Ala Thr Asp 
    9485                 9490                 9495             


Ile Gln  Glu Glu Pro Glu Val  Phe Ile Asp Ile Gly  Ala Gln Asp 
    9500                 9505                 9510             


Cys Leu  Val Cys Lys Ala Gly  Ser Gln Ile Arg Ile  Pro Ala Val 
    9515                 9520                 9525             


Ile Lys  Gly Arg Pro Thr Pro  Lys Ser Ser Trp Glu  Phe Asp Gly 
    9530                 9535                 9540             


Lys Ala  Lys Lys Ala Met Lys  Asp Gly Val His Asp  Ile Pro Glu 
    9545                 9550                 9555             


Asp Ala  Gln Leu Glu Thr Ala  Glu Asn Ser Ser Val  Ile Ile Ile 
    9560                 9565                 9570             


Pro Glu  Cys Lys Arg Ser His  Thr Gly Lys Tyr Ser  Ile Thr Ala 
    9575                 9580                 9585             


Lys Asn  Lys Ala Gly Gln Lys  Thr Ala Asn Cys Arg  Val Lys Val 
    9590                 9595                 9600             


Met Asp  Val Pro Gly Pro Pro  Lys Asp Leu Lys Val  Ser Asp Ile 
    9605                 9610                 9615             


Thr Arg  Gly Ser Cys Arg Leu  Ser Trp Lys Met Pro  Asp Asp Asp 
    9620                 9625                 9630             


Gly Gly  Asp Arg Ile Lys Gly  Tyr Val Ile Glu Lys  Arg Thr Ile 
    9635                 9640                 9645             


Asp Gly  Lys Ala Trp Thr Lys  Val Asn Pro Asp Cys  Gly Ser Thr 
    9650                 9655                 9660             


Thr Phe  Val Val Pro Asp Leu  Leu Ser Glu Gln Gln  Tyr Phe Phe 
    9665                 9670                 9675             


Arg Val  Arg Ala Glu Asn Arg  Phe Gly Ile Gly Pro  Pro Val Glu 
    9680                 9685                 9690             


Thr Ile  Gln Arg Thr Thr Ala  Arg Asp Pro Ile Tyr  Pro Pro Asp 
    9695                 9700                 9705             


Pro Pro  Ile Lys Leu Lys Ile  Gly Leu Ile Thr Lys  Asn Thr Val 
    9710                 9715                 9720             


His Leu  Ser Trp Lys Pro Pro  Lys Asn Asp Gly Gly  Ser Pro Val 
    9725                 9730                 9735             


Thr His  Tyr Ile Val Glu Cys  Leu Ala Trp Asp Pro  Thr Gly Thr 
    9740                 9745                 9750             


Lys Lys  Glu Ala Trp Arg Gln  Cys Asn Lys Arg Asp  Val Glu Glu 
    9755                 9760                 9765             


Leu Gln  Phe Thr Val Glu Asp  Leu Val Glu Gly Gly  Glu Tyr Glu 
    9770                 9775                 9780             


Phe Arg  Val Lys Ala Val Asn  Ala Ala Gly Val Ser  Lys Pro Ser 
    9785                 9790                 9795             


Ala Thr  Val Gly Pro Cys Asp  Cys Gln Arg Pro Asp  Met Pro Pro 
    9800                 9805                 9810             


Ser Ile  Asp Leu Lys Glu Phe  Met Glu Val Glu Glu  Gly Thr Asn 
    9815                 9820                 9825             


Val Asn  Ile Val Ala Lys Ile  Lys Gly Val Pro Phe  Pro Thr Leu 
    9830                 9835                 9840             


Thr Trp  Phe Lys Ala Pro Pro  Lys Lys Pro Asp Asn  Lys Glu Pro 
    9845                 9850                 9855             


Val Leu  Tyr Asp Thr His Val  Asn Lys Leu Val Val  Asp Asp Thr 
    9860                 9865                 9870             


Cys Thr  Leu Val Ile Pro Gln  Ser Arg Arg Ser Asp  Thr Gly Leu 
    9875                 9880                 9885             


Tyr Thr  Ile Thr Ala Val Asn  Asn Leu Gly Thr Ala  Ser Lys Glu 
    9890                 9895                 9900             


Met Arg  Leu Asn Val Leu Gly  Arg Pro Gly Pro Pro  Val Gly Pro 
    9905                 9910                 9915             


Ile Lys  Phe Glu Ser Val Ser  Ala Asp Gln Met Thr  Leu Ser Trp 
    9920                 9925                 9930             


Phe Pro  Pro Lys Asp Asp Gly  Gly Ser Lys Ile Thr  Asn Tyr Val 
    9935                 9940                 9945             


Ile Glu  Lys Arg Glu Ala Asn  Arg Lys Thr Trp Val  His Val Ser 
    9950                 9955                 9960             


Ser Glu  Pro Lys Glu Cys Thr  Tyr Thr Ile Pro Lys  Leu Leu Glu 
    9965                 9970                 9975             


Gly His  Glu Tyr Val Phe Arg  Ile Met Ala Gln Asn  Lys Tyr Gly 
    9980                 9985                 9990             


Ile Gly  Glu Pro Leu Asp Ser   Glu Pro Glu Thr Ala   Arg Asn Leu 
    9995                 10000                 10005             


Phe Ser   Val Pro Gly Ala Pro   Asp Lys Pro Thr Val   Ser Ser Val 
    10010                 10015                 10020             


Thr Arg   Asn Ser Met Thr Val   Asn Trp Glu Glu Pro   Glu Tyr Asp 
    10025                 10030                 10035             


Gly Gly   Ser Pro Val Thr Gly   Tyr Trp Leu Glu Met   Lys Asp Thr 
    10040                 10045                 10050             


Thr Ser   Lys Arg Trp Lys Arg   Val Asn Arg Asp Pro   Ile Lys Ala 
    10055                 10060                 10065             


Met Thr   Leu Gly Val Ser Tyr   Lys Val Thr Gly Leu   Ile Glu Gly 
    10070                 10075                 10080             


Ser Asp   Tyr Gln Phe Arg Val   Tyr Ala Ile Asn Ala   Ala Gly Val 
    10085                 10090                 10095             


Gly Pro   Ala Ser Leu Pro Ser   Asp Pro Ala Thr Ala   Arg Asp Pro 
    10100                 10105                 10110             


Ile Ala   Pro Pro Gly Pro Pro   Phe Pro Lys Val Thr   Asp Trp Thr 
    10115                 10120                 10125             


Lys Ser   Ser Ala Asp Leu Glu   Trp Ser Pro Pro Leu   Lys Asp Gly 
    10130                 10135                 10140             


Gly Ser   Lys Val Thr Gly Tyr   Ile Val Glu Tyr Lys   Glu Glu Gly 
    10145                 10150                 10155             


Lys Glu   Glu Trp Glu Lys Gly   Lys Asp Lys Glu Val   Arg Gly Thr 
    10160                 10165                 10170             


Lys Leu   Val Val Thr Gly Leu   Lys Glu Gly Ala Phe   Tyr Lys Phe 
    10175                 10180                 10185             


Arg Val   Ser Ala Val Asn Ile   Ala Gly Ile Gly Glu   Pro Gly Glu 
    10190                 10195                 10200             


Val Thr   Asp Val Ile Glu Met   Lys Asp Arg Leu Val   Ser Pro Asp 
    10205                 10210                 10215             


Leu Gln   Leu Asp Ala Ser Val   Arg Asp Arg Ile Val   Val His Ala 
    10220                 10225                 10230             


Gly Gly   Val Ile Arg Ile Ile   Ala Tyr Val Ser Gly   Lys Pro Pro 
    10235                 10240                 10245             


Pro Thr   Val Thr Trp Asn Met   Asn Glu Arg Thr Leu   Pro Gln Glu 
    10250                 10255                 10260             


Ala Thr   Ile Glu Thr Thr Ala   Ile Ser Ser Ser Met   Val Ile Lys 
    10265                 10270                 10275             


Asn Cys   Gln Arg Ser His Gln   Gly Val Tyr Ser Leu   Leu Ala Lys 
    10280                 10285                 10290             


Asn Glu   Ala Gly Glu Arg Lys   Lys Thr Ile Ile Val   Asp Val Leu 
    10295                 10300                 10305             


Asp Val   Pro Gly Pro Val Gly   Thr Pro Phe Leu Ala   His Asn Leu 
    10310                 10315                 10320             


Thr Asn   Glu Ser Cys Lys Leu   Thr Trp Phe Ser Pro   Glu Asp Asp 
    10325                 10330                 10335             


Gly Gly   Ser Pro Ile Thr Asn   Tyr Val Ile Glu Lys   Arg Glu Ser 
    10340                 10345                 10350             


Asp Arg   Arg Ala Trp Thr Pro   Val Thr Tyr Thr Val   Thr Arg Gln 
    10355                 10360                 10365             


Asn Ala   Thr Val Gln Gly Leu   Ile Gln Gly Lys Ala   Tyr Phe Phe 
    10370                 10375                 10380             


Arg Ile   Ala Ala Glu Asn Ser   Ile Gly Met Gly Pro   Phe Val Glu 
    10385                 10390                 10395             


Thr Ser   Glu Ala Leu Val Ile   Arg Glu Pro Ile Thr   Val Pro Glu 
    10400                 10405                 10410             


Arg Pro   Glu Asp Leu Glu Val   Lys Glu Val Thr Lys   Asn Thr Val 
    10415                 10420                 10425             


Thr Leu   Thr Trp Asn Pro Pro   Lys Tyr Asp Gly Gly   Ser Glu Ile 
    10430                 10435                 10440             


Ile Asn   Tyr Val Leu Glu Ser   Arg Leu Ile Gly Thr   Glu Lys Phe 
    10445                 10450                 10455             


His Lys   Val Thr Asn Asp Asn   Leu Leu Ser Arg Lys   Tyr Thr Val 
    10460                 10465                 10470             


Lys Gly   Leu Lys Glu Gly Asp   Thr Tyr Glu Tyr Arg   Val Ser Ala 
    10475                 10480                 10485             


Val Asn   Ile Val Gly Gln Gly   Lys Pro Ser Phe Cys   Thr Lys Pro 
    10490                 10495                 10500             


Ile Thr   Cys Lys Asp Glu Leu   Ala Pro Pro Thr Leu   His Leu Asp 
    10505                 10510                 10515             


Phe Arg   Asp Lys Leu Thr Ile   Arg Val Gly Glu Ala   Phe Ala Leu 
    10520                 10525                 10530             


Thr Gly   Arg Tyr Ser Gly Lys   Pro Lys Pro Lys Val   Ser Trp Phe 
    10535                 10540                 10545             


Lys Asp   Glu Ala Asp Val Leu   Glu Asp Asp Arg Thr   His Ile Lys 
    10550                 10555                 10560             


Thr Thr   Pro Ala Thr Leu Ala   Leu Glu Lys Ile Lys   Ala Lys Arg 
    10565                 10570                 10575             


Ser Asp   Ser Gly Lys Tyr Cys   Val Val Val Glu Asn   Ser Thr Gly 
    10580                 10585                 10590             


Ser Arg   Lys Gly Phe Cys Gln   Val Asn Val Val Asp   Arg Pro Gly 
    10595                 10600                 10605             


Pro Pro   Val Gly Pro Val Ser   Phe Asp Glu Val Thr   Lys Asp Tyr 
    10610                 10615                 10620             


Met Val   Ile Ser Trp Lys Pro   Pro Leu Asp Asp Gly   Gly Ser Lys 
    10625                 10630                 10635             


Ile Thr   Asn Tyr Ile Ile Glu   Lys Lys Glu Val Gly   Lys Asp Val 
    10640                 10645                 10650             


Trp Met   Pro Val Thr Ser Ala   Ser Ala Lys Thr Thr   Cys Lys Val 
    10655                 10660                 10665             


Ser Lys   Leu Leu Glu Gly Lys   Asp Tyr Ile Phe Arg   Ile His Ala 
    10670                 10675                 10680             


Glu Asn   Leu Tyr Gly Ile Ser   Asp Pro Leu Val Ser   Asp Ser Met 
    10685                 10690                 10695             


Lys Ala   Lys Asp Arg Phe Arg   Val Pro Asp Ala Pro   Asp Gln Pro 
    10700                 10705                 10710             


Ile Val   Thr Glu Val Thr Lys   Asp Ser Ala Leu Val   Thr Trp Asn 
    10715                 10720                 10725             


Lys Pro   His Asp Gly Gly Lys   Pro Ile Thr Asn Tyr   Ile Leu Glu 
    10730                 10735                 10740             


Lys Arg   Glu Thr Met Ser Lys   Arg Trp Ala Arg Val   Thr Lys Asp 
    10745                 10750                 10755             


Pro Ile   His Pro Tyr Thr Lys   Phe Arg Val Pro Asp   Leu Leu Glu 
    10760                 10765                 10770             


Gly Cys   Gln Tyr Glu Phe Arg   Val Ser Ala Glu Asn   Glu Ile Gly 
    10775                 10780                 10785             


Ile Gly   Asp Pro Ser Pro Pro   Ser Lys Pro Val Phe   Ala Lys Asp 
    10790                 10795                 10800             


Pro Ile   Ala Lys Pro Ser Pro   Pro Val Asn Pro Glu   Ala Ile Asp 
    10805                 10810                 10815             


Thr Thr   Cys Asn Ser Val Asp   Leu Thr Trp Gln Pro   Pro Arg His 
    10820                 10825                 10830             


Asp Gly   Gly Ser Lys Ile Leu   Gly Tyr Ile Val Glu   Tyr Gln Lys 
    10835                 10840                 10845             


Val Gly   Asp Glu Glu Trp Arg   Arg Ala Asn His Thr   Pro Glu Ser 
    10850                 10855                 10860             


Cys Pro   Glu Thr Lys Tyr Lys   Val Thr Gly Leu Arg   Asp Gly Gln 
    10865                 10870                 10875             


Thr Tyr   Lys Phe Arg Val Leu   Ala Val Asn Ala Ala   Gly Glu Ser 
    10880                 10885                 10890             


Asp Pro   Ala His Val Pro Glu   Pro Val Leu Val Lys   Asp Arg Leu 
    10895                 10900                 10905             


Glu Pro   Pro Glu Leu Ile Leu   Asp Ala Asn Met Ala   Arg Glu Gln 
    10910                 10915                 10920             


His Ile   Lys Val Gly Asp Thr   Leu Arg Leu Ser Ala   Ile Ile Lys 
    10925                 10930                 10935             


Gly Val   Pro Phe Pro Lys Val   Thr Trp Lys Lys Glu   Asp Arg Asp 
    10940                 10945                 10950             


Ala Pro   Thr Lys Ala Arg Ile   Asp Val Thr Pro Val   Gly Ser Lys 
    10955                 10960                 10965             


Leu Glu   Ile Arg Asn Ala Ala   His Glu Asp Gly Gly   Ile Tyr Ser 
    10970                 10975                 10980             


Leu Thr   Val Glu Asn Pro Ala   Gly Ser Lys Thr Val   Ser Val Lys 
    10985                 10990                 10995             


Val Leu   Val Leu Asp Lys Pro   Gly Pro Pro Arg Asp   Leu Glu Val 
    11000                 11005                 11010             


Ser Glu   Ile Arg Lys Asp Ser   Cys Tyr Leu Thr Trp   Lys Glu Pro 
    11015                 11020                 11025             


Leu Asp   Asp Gly Gly Ser Val   Ile Thr Asn Tyr Val   Val Glu Arg 
    11030                 11035                 11040             


Arg Asp   Val Ala Ser Ala Gln   Trp Ser Pro Leu Ser   Ala Thr Ser 
    11045                 11050                 11055             


Lys Lys   Lys Ser His Phe Ala   Lys His Leu Asn Glu   Gly Asn Gln 
    11060                 11065                 11070             


Tyr Leu   Phe Arg Val Ala Ala   Glu Asn Gln Tyr Gly   Arg Gly Pro 
    11075                 11080                 11085             


Phe Val   Glu Thr Pro Lys Pro   Ile Lys Ala Leu Asp   Pro Leu His 
    11090                 11095                 11100             


Pro Pro   Gly Pro Pro Lys Asp   Leu His His Val Asp   Val Asp Lys 
    11105                 11110                 11115             


Thr Glu   Val Ser Leu Val Trp   Asn Lys Pro Asp Arg   Asp Gly Gly 
    11120                 11125                 11130             


Ser Pro   Ile Thr Gly Tyr Leu   Val Glu Tyr Gln Glu   Glu Gly Thr 
    11135                 11140                 11145             


Gln Asp   Trp Ile Lys Phe Lys   Thr Val Thr Asn Leu   Glu Cys Val 
    11150                 11155                 11160             


Val Thr   Gly Leu Gln Gln Gly   Lys Thr Tyr Arg Phe   Arg Val Lys 
    11165                 11170                 11175             


Ala Glu   Asn Ile Val Gly Leu   Gly Leu Pro Asp Thr   Thr Ile Pro 
    11180                 11185                 11190             


Ile Glu   Cys Gln Glu Lys Leu   Val Pro Pro Ser Val   Glu Leu Asp 
    11195                 11200                 11205             


Val Lys   Leu Ile Glu Gly Leu   Val Val Lys Ala Gly   Thr Thr Val 
    11210                 11215                 11220             


Arg Phe   Pro Ala Ile Ile Arg   Gly Val Pro Val Pro   Thr Ala Lys 
    11225                 11230                 11235             


Trp Thr   Thr Asp Gly Ser Glu   Ile Lys Thr Asp Glu   His Tyr Thr 
    11240                 11245                 11250             


Val Glu   Thr Asp Asn Phe Ser   Ser Val Leu Thr Ile   Lys Asn Cys 
    11255                 11260                 11265             


Leu Arg   Arg Asp Thr Gly Glu   Tyr Gln Ile Thr Val   Ser Asn Ala 
    11270                 11275                 11280             


Ala Gly   Ser Lys Thr Val Ala   Val His Leu Thr Val   Leu Asp Val 
    11285                 11290                 11295             


Pro Gly   Pro Pro Thr Gly Pro   Ile Asn Ile Leu Asp   Val Thr Pro 
    11300                 11305                 11310             


Glu His   Met Thr Ile Ser Trp   Gln Pro Pro Lys Asp   Asp Gly Gly 
    11315                 11320                 11325             


Ser Pro   Val Ile Asn Tyr Ile   Val Glu Lys Gln Asp   Thr Arg Lys 
    11330                 11335                 11340             


Asp Thr   Trp Gly Val Val Ser   Ser Gly Ser Ser Lys   Thr Lys Leu 
    11345                 11350                 11355             


Lys Ile   Pro His Leu Gln Lys   Gly Cys Glu Tyr Val   Phe Arg Val 
    11360                 11365                 11370             


Arg Ala   Glu Asn Lys Ile Gly   Val Gly Pro Pro Leu   Asp Ser Thr 
    11375                 11380                 11385             


Pro Thr   Val Ala Lys His Lys   Phe Ser Pro Pro Ser   Pro Pro Gly 
    11390                 11395                 11400             


Lys Pro   Val Val Thr Asp Ile   Thr Glu Asn Ala Ala   Thr Val Ser 
    11405                 11410                 11415             


Trp Thr   Leu Pro Lys Ser Asp   Gly Gly Ser Pro Ile   Thr Gly Tyr 
    11420                 11425                 11430             


Tyr Met   Glu Arg Arg Glu Val   Thr Gly Lys Trp Val   Arg Val Asn 
    11435                 11440                 11445             


Lys Thr   Pro Ile Ala Asp Leu   Lys Phe Arg Val Thr   Gly Leu Tyr 
    11450                 11455                 11460             


Glu Gly   Asn Thr Tyr Glu Phe   Arg Val Phe Ala Glu   Asn Leu Ala 
    11465                 11470                 11475             


Gly Leu   Ser Lys Pro Ser Pro   Ser Ser Asp Pro Ile   Lys Ala Cys 
    11480                 11485                 11490             


Arg Pro   Ile Lys Pro Pro Gly   Pro Pro Ile Asn Pro   Lys Leu Lys 
    11495                 11500                 11505             


Asp Lys   Ser Arg Glu Thr Ala   Asp Leu Val Trp Thr   Lys Pro Leu 
    11510                 11515                 11520             


Ser Asp   Gly Gly Ser Pro Ile   Leu Gly Tyr Val Val   Glu Cys Gln 
    11525                 11530                 11535             


Lys Pro   Gly Thr Ala Gln Trp   Asn Arg Ile Asn Lys   Asp Glu Leu 
    11540                 11545                 11550             


Ile Arg   Gln Cys Ala Phe Arg   Val Pro Gly Leu Ile   Glu Gly Asn 
    11555                 11560                 11565             


Glu Tyr   Arg Phe Arg Ile Lys   Ala Ala Asn Ile Val   Gly Glu Gly 
    11570                 11575                 11580             


Glu Pro   Arg Glu Leu Ala Glu   Ser Val Ile Ala Lys   Asp Ile Leu 
    11585                 11590                 11595             


His Pro   Pro Glu Val Glu Leu   Asp Val Thr Cys Arg   Asp Val Ile 
    11600                 11605                 11610             


Thr Val   Arg Val Gly Gln Thr   Ile Arg Ile Leu Ala   Arg Val Lys 
    11615                 11620                 11625             


Gly Arg   Pro Glu Pro Asp Ile   Thr Trp Thr Lys Glu   Gly Lys Val 
    11630                 11635                 11640             


Leu Val   Arg Glu Lys Arg Val   Asp Leu Ile Gln Asp   Leu Pro Arg 
    11645                 11650                 11655             


Val Glu   Leu Gln Ile Lys Glu   Ala Val Arg Ala Asp   His Gly Lys 
    11660                 11665                 11670             


Tyr Ile   Ile Ser Ala Lys Asn   Ser Ser Gly His Ala   Gln Gly Ser 
    11675                 11680                 11685             


Ala Ile   Val Asn Val Leu Asp   Arg Pro Gly Pro Cys   Gln Asn Leu 
    11690                 11695                 11700             


Lys Val   Thr Asn Val Thr Lys   Glu Asn Cys Thr Ile   Ser Trp Glu 
    11705                 11710                 11715             


Asn Pro   Leu Asp Asn Gly Gly   Ser Glu Ile Thr Asn   Phe Ile Val 
    11720                 11725                 11730             


Glu Tyr   Arg Lys Pro Asn Gln   Lys Gly Trp Ser Ile   Val Ala Ser 
    11735                 11740                 11745             


Asp Val   Thr Lys Arg Leu Ile   Lys Ala Asn Leu Leu   Ala Asn Asn 
    11750                 11755                 11760             


Glu Tyr   Tyr Phe Arg Val Cys   Ala Glu Asn Lys Val   Gly Val Gly 
    11765                 11770                 11775             


Pro Thr   Ile Glu Thr Lys Thr   Pro Ile Leu Ala Ile   Asn Pro Ile 
    11780                 11785                 11790             


Asp Arg   Pro Gly Glu Pro Glu   Asn Leu His Ile Ala   Asp Lys Gly 
    11795                 11800                 11805             


Lys Thr   Phe Val Tyr Leu Lys   Trp Arg Arg Pro Asp   Tyr Asp Gly 
    11810                 11815                 11820             


Gly Ser   Pro Asn Leu Ser Tyr   His Val Glu Arg Arg   Leu Lys Gly 
    11825                 11830                 11835             


Ser Asp   Asp Trp Glu Arg Val   His Lys Gly Ser Ile   Lys Glu Thr 
    11840                 11845                 11850             


His Tyr   Met Val Asp Arg Cys   Val Glu Asn Gln Ile   Tyr Glu Phe 
    11855                 11860                 11865             


Arg Val   Gln Thr Lys Asn Glu   Gly Gly Glu Ser Asp   Trp Val Lys 
    11870                 11875                 11880             


Thr Glu   Glu Val Val Val Lys   Glu Asp Leu Gln Lys   Pro Val Leu 
    11885                 11890                 11895             


Asp Leu   Lys Leu Ser Gly Val   Leu Thr Val Lys Ala   Gly Asp Thr 
    11900                 11905                 11910             


Ile Arg   Leu Glu Ala Gly Val   Arg Gly Lys Pro Phe   Pro Glu Val 
    11915                 11920                 11925             


Ala Trp   Thr Lys Asp Lys Asp   Ala Thr Asp Leu Thr   Arg Ser Pro 
    11930                 11935                 11940             


Arg Val   Lys Ile Asp Thr Arg   Ala Asp Ser Ser Lys   Phe Ser Leu 
    11945                 11950                 11955             


Thr Lys   Ala Lys Arg Ser Asp   Gly Gly Lys Tyr Val   Val Thr Ala 
    11960                 11965                 11970             


Thr Asn   Thr Ala Gly Ser Phe   Val Ala Tyr Ala Thr   Val Asn Val 
    11975                 11980                 11985             


Leu Asp   Lys Pro Gly Pro Val   Arg Asn Leu Lys Ile   Val Asp Val 
    11990                 11995                 12000             


Ser Ser   Asp Arg Cys Thr Val   Cys Trp Asp Pro Pro   Glu Asp Asp 
    12005                 12010                 12015             


Gly Gly   Cys Glu Ile Gln Asn   Tyr Ile Leu Glu Lys   Cys Glu Thr 
    12020                 12025                 12030             


Lys Arg   Met Val Trp Ser Thr   Tyr Ser Ala Thr Val   Leu Thr Pro 
    12035                 12040                 12045             


Gly Thr   Thr Val Thr Arg Leu   Ile Glu Gly Asn Glu   Tyr Ile Phe 
    12050                 12055                 12060             


Arg Val   Arg Ala Glu Asn Lys   Ile Gly Thr Gly Pro   Pro Thr Glu 
    12065                 12070                 12075             


Ser Lys   Pro Val Ile Ala Lys   Thr Lys Tyr Asp Lys   Pro Gly Arg 
    12080                 12085                 12090             


Pro Asp   Pro Pro Glu Val Thr   Lys Val Ser Lys Glu   Glu Met Thr 
    12095                 12100                 12105             


Val Val   Trp Asn Pro Pro Glu   Tyr Asp Gly Gly Lys   Ser Ile Thr 
    12110                 12115                 12120             


Gly Tyr   Phe Leu Glu Lys Lys   Glu Lys His Ser Thr   Arg Trp Val 
    12125                 12130                 12135             


Pro Val   Asn Lys Ser Ala Ile   Pro Glu Arg Arg Met   Lys Val Gln 
    12140                 12145                 12150             


Asn Leu   Leu Pro Asp His Glu   Tyr Gln Phe Arg Val   Lys Ala Glu 
    12155                 12160                 12165             


Asn Glu   Ile Gly Ile Gly Glu   Pro Ser Leu Pro Ser   Arg Pro Val 
    12170                 12175                 12180             


Val Ala   Lys Asp Pro Ile Glu   Pro Pro Gly Pro Pro   Thr Asn Phe 
    12185                 12190                 12195             


Arg Val   Val Asp Thr Thr Lys   His Ser Ile Thr Leu   Gly Trp Gly 
    12200                 12205                 12210             


Lys Pro   Val Tyr Asp Gly Gly   Ala Pro Ile Ile Gly   Tyr Val Val 
    12215                 12220                 12225             


Glu Met   Arg Pro Lys Ile Ala   Asp Ala Ser Pro Asp   Glu Gly Trp 
    12230                 12235                 12240             


Lys Arg   Cys Asn Ala Ala Ala   Gln Leu Val Arg Lys   Glu Phe Thr 
    12245                 12250                 12255             


Val Thr   Ser Leu Asp Glu Asn   Gln Glu Tyr Glu Phe   Arg Val Cys 
    12260                 12265                 12270             


Ala Gln   Asn Gln Val Gly Ile   Gly Arg Pro Ala Glu   Leu Lys Glu 
    12275                 12280                 12285             


Ala Ile   Lys Pro Lys Glu Ile   Leu Glu Pro Pro Glu   Ile Asp Leu 
    12290                 12295                 12300             


Asp Ala   Ser Met Arg Lys Leu   Val Ile Val Arg Ala   Gly Cys Pro 
    12305                 12310                 12315             


Ile Arg   Leu Phe Ala Ile Val   Arg Gly Arg Pro Ala   Pro Lys Val 
    12320                 12325                 12330             


Thr Trp   Arg Lys Val Gly Ile   Asp Asn Val Val Arg   Lys Gly Gln 
    12335                 12340                 12345             


Val Asp   Leu Val Asp Thr Met   Ala Phe Leu Val Ile   Pro Asn Ser 
    12350                 12355                 12360             


Thr Arg   Asp Asp Ser Gly Lys   Tyr Ser Leu Thr Leu   Val Asn Pro 
    12365                 12370                 12375             


Ala Gly   Glu Lys Ala Val Phe   Val Asn Val Arg Val   Leu Asp Thr 
    12380                 12385                 12390             


Pro Gly   Pro Val Ser Asp Leu   Lys Val Ser Asp Val   Thr Lys Thr 
    12395                 12400                 12405             


Ser Cys   His Val Ser Trp Ala   Pro Pro Glu Asn Asp   Gly Gly Ser 
    12410                 12415                 12420             


Gln Val   Thr His Tyr Ile Val   Glu Lys Arg Glu Ala   Asp Arg Lys 
    12425                 12430                 12435             


Thr Trp   Ser Thr Val Thr Pro   Glu Val Lys Lys Thr   Ser Phe His 
    12440                 12445                 12450             


Val Thr   Asn Leu Val Pro Gly   Asn Glu Tyr Tyr Phe   Arg Val Thr 
    12455                 12460                 12465             


Ala Val   Asn Glu Tyr Gly Pro   Gly Val Pro Thr Asp   Val Pro Lys 
    12470                 12475                 12480             


Pro Val   Leu Ala Ser Asp Pro   Leu Ser Glu Pro Asp   Pro Pro Arg 
    12485                 12490                 12495             


Lys Leu   Glu Val Thr Glu Met   Thr Lys Asn Ser Ala   Thr Leu Ala 
    12500                 12505                 12510             


Trp Leu   Pro Pro Leu Arg Asp   Gly Gly Ala Lys Ile   Asp Gly Tyr 
    12515                 12520                 12525             


Ile Thr   Ser Tyr Arg Glu Glu   Glu Gln Pro Ala Asp   Arg Trp Thr 
    12530                 12535                 12540             


Glu Tyr   Ser Val Val Lys Asp   Leu Ser Leu Val Val   Thr Gly Leu 
    12545                 12550                 12555             


Lys Glu   Gly Lys Lys Tyr Lys   Phe Arg Val Ala Ala   Arg Asn Ala 
    12560                 12565                 12570             


Val Gly   Val Ser Leu Pro Arg   Glu Ala Glu Gly Val   Tyr Glu Ala 
    12575                 12580                 12585             


Lys Glu   Gln Leu Leu Pro Pro   Lys Ile Leu Met Pro   Glu Gln Ile 
    12590                 12595                 12600             


Thr Ile   Lys Ala Gly Lys Lys   Leu Arg Ile Glu Ala   His Val Tyr 
    12605                 12610                 12615             


Gly Lys   Pro His Pro Thr Cys   Lys Trp Lys Lys Gly   Glu Asp Glu 
    12620                 12625                 12630             


Val Val   Thr Ser Ser His Leu   Ala Val His Lys Ala   Asp Ser Ser 
    12635                 12640                 12645             


Ser Ile   Leu Ile Ile Lys Asp   Val Thr Arg Lys Asp   Ser Gly Tyr 
    12650                 12655                 12660             


Tyr Ser   Leu Thr Ala Glu Asn   Ser Ser Gly Thr Asp   Thr Gln Lys 
    12665                 12670                 12675             


Ile Lys   Val Val Val Met Asp   Ala Pro Gly Pro Pro   Gln Pro Pro 
    12680                 12685                 12690             


Phe Asp   Ile Ser Asp Ile Asp   Ala Asp Ala Cys Ser   Leu Ser Trp 
    12695                 12700                 12705             


His Ile   Pro Leu Glu Asp Gly   Gly Ser Asn Ile Thr   Asn Tyr Ile 
    12710                 12715                 12720             


Val Glu   Lys Cys Asp Val Ser   Arg Gly Asp Trp Val   Thr Ala Leu 
    12725                 12730                 12735             


Ala Ser   Val Thr Lys Thr Ser   Cys Arg Val Gly Lys   Leu Ile Pro 
    12740                 12745                 12750             


Gly Gln   Glu Tyr Ile Phe Arg   Val Arg Ala Glu Asn   Arg Phe Gly 
    12755                 12760                 12765             


Ile Ser   Glu Pro Leu Thr Ser   Pro Lys Met Val Ala   Gln Phe Pro 
    12770                 12775                 12780             


Phe Gly   Val Pro Ser Glu Pro   Lys Asn Ala Arg Val   Thr Lys Val 
    12785                 12790                 12795             


Asn Lys   Asp Cys Ile Phe Val   Ala Trp Asp Arg Pro   Asp Ser Asp 
    12800                 12805                 12810             


Gly Gly   Ser Pro Ile Ile Gly   Tyr Leu Ile Glu Arg   Lys Glu Arg 
    12815                 12820                 12825             


Asn Ser   Leu Leu Trp Val Lys   Ala Asn Asp Thr Leu   Val Arg Ser 
    12830                 12835                 12840             


Thr Glu   Tyr Pro Cys Ala Gly   Leu Val Glu Gly Leu   Glu Tyr Ser 
    12845                 12850                 12855             


Phe Arg   Ile Tyr Ala Leu Asn   Lys Ala Gly Ser Ser   Pro Pro Ser 
    12860                 12865                 12870             


Lys Pro   Thr Glu Tyr Val Thr   Ala Arg Met Pro Val   Asp Pro Pro 
    12875                 12880                 12885             


Gly Lys   Pro Glu Val Ile Asp   Val Thr Lys Ser Thr   Val Ser Leu 
    12890                 12895                 12900             


Ile Trp   Ala Arg Pro Lys His   Asp Gly Gly Ser Lys   Ile Ile Gly 
    12905                 12910                 12915             


Tyr Phe   Val Glu Ala Cys Lys   Leu Pro Gly Asp Lys   Trp Val Arg 
    12920                 12925                 12930             


Cys Asn   Thr Ala Pro His Gln   Ile Pro Gln Glu Glu   Tyr Thr Ala 
    12935                 12940                 12945             


Thr Gly   Leu Glu Glu Lys Ala   Gln Tyr Gln Phe Arg   Ala Ile Ala 
    12950                 12955                 12960             


Arg Thr   Ala Val Asn Ile Ser   Pro Pro Ser Glu Pro   Ser Asp Pro 
    12965                 12970                 12975             


Val Thr   Ile Leu Ala Glu Asn   Val Pro Pro Arg Ile   Asp Leu Ser 
    12980                 12985                 12990             


Val Ala   Met Lys Ser Leu Leu   Thr Val Lys Ala Gly   Thr Asn Val 
    12995                 13000                 13005             


Cys Leu   Asp Ala Thr Val Phe   Gly Lys Pro Met Pro   Thr Val Ser 
    13010                 13015                 13020             


Trp Lys   Lys Asp Gly Thr Leu   Leu Lys Pro Ala Glu   Gly Ile Lys 
    13025                 13030                 13035             


Met Ala   Met Gln Arg Asn Leu   Cys Thr Leu Glu Leu   Phe Ser Val 
    13040                 13045                 13050             


Asn Arg   Lys Asp Ser Gly Asp   Tyr Thr Ile Thr Ala   Glu Asn Ser 
    13055                 13060                 13065             


Ser Gly   Ser Lys Ser Ala Thr   Ile Lys Leu Lys Val   Leu Asp Lys 
    13070                 13075                 13080             


Pro Gly   Pro Pro Ala Ser Val   Lys Ile Asn Lys Met   Tyr Ser Asp 
    13085                 13090                 13095             


Arg Ala   Met Leu Ser Trp Glu   Pro Pro Leu Glu Asp   Gly Gly Ser 
    13100                 13105                 13110             


Glu Ile   Thr Asn Tyr Ile Val   Asp Lys Arg Glu Thr   Ser Arg Pro 
    13115                 13120                 13125             


Asn Trp   Ala Gln Val Ser Ala   Thr Val Pro Ile Thr   Ser Cys Ser 
    13130                 13135                 13140             


Val Glu   Lys Leu Ile Glu Gly   His Glu Tyr Gln Phe   Arg Ile Cys 
    13145                 13150                 13155             


Ala Glu   Asn Lys Tyr Gly Val   Gly Asp Pro Val Phe   Thr Glu Pro 
    13160                 13165                 13170             


Ala Ile   Ala Lys Asn Pro Tyr   Asp Pro Pro Gly Arg   Cys Asp Pro 
    13175                 13180                 13185             


Pro Val   Ile Ser Asn Ile Thr   Lys Asp His Met Thr   Val Ser Trp 
    13190                 13195                 13200             


Lys Pro   Pro Ala Asp Asp Gly   Gly Ser Pro Ile Thr   Gly Tyr Leu 
    13205                 13210                 13215             


Leu Glu   Lys Arg Glu Thr Gln   Ala Val Asn Trp Thr   Lys Val Asn 
    13220                 13225                 13230             


Arg Lys   Pro Ile Ile Glu Arg   Thr Leu Lys Ala Thr   Gly Leu Gln 
    13235                 13240                 13245             


Glu Gly   Thr Glu Tyr Glu Phe   Arg Val Thr Ala Ile   Asn Lys Ala 
    13250                 13255                 13260             


Gly Pro   Gly Lys Pro Ser Asp   Ala Ser Lys Ala Ala   Tyr Ala Arg 
    13265                 13270                 13275             


Asp Pro   Gln Tyr Pro Pro Ala   Pro Pro Ala Phe Pro   Lys Val Tyr 
    13280                 13285                 13290             


Asp Thr   Thr Arg Ser Ser Val   Ser Leu Ser Trp Gly   Lys Pro Ala 
    13295                 13300                 13305             


Tyr Asp   Gly Gly Ser Pro Ile   Ile Gly Tyr Leu Val   Glu Val Lys 
    13310                 13315                 13320             


Arg Ala   Asp Ser Asp Asn Trp   Val Arg Cys Asn Leu   Pro Gln Asn 
    13325                 13330                 13335             


Leu Gln   Lys Thr Arg Phe Glu   Val Thr Gly Leu Met   Glu Asp Thr 
    13340                 13345                 13350             


Gln Tyr   Gln Phe Arg Val Tyr   Ala Val Asn Lys Ile   Gly Tyr Ser 
    13355                 13360                 13365             


Asp Pro   Ser Asp Val Pro Asp   Lys His Tyr Pro Lys   Asp Ile Leu 
    13370                 13375                 13380             


Ile Pro   Pro Glu Gly Glu Leu   Asp Ala Asp Leu Arg   Lys Thr Leu 
    13385                 13390                 13395             


Ile Leu   Arg Ala Gly Val Thr   Met Arg Leu Tyr Val   Pro Val Lys 
    13400                 13405                 13410             


Gly Arg   Pro Pro Pro Lys Ile   Thr Trp Ser Lys Pro   Asn Val Asn 
    13415                 13420                 13425             


Leu Arg   Asp Arg Ile Gly Leu   Asp Ile Lys Ser Thr   Asp Phe Asp 
    13430                 13435                 13440             


Thr Phe   Leu Arg Cys Glu Asn   Val Asn Lys Tyr Asp   Ala Gly Lys 
    13445                 13450                 13455             


Tyr Ile   Leu Thr Leu Glu Asn   Ser Cys Gly Lys Lys   Glu Tyr Thr 
    13460                 13465                 13470             


Ile Val   Val Lys Val Leu Asp   Thr Pro Gly Pro Pro   Val Asn Val 
    13475                 13480                 13485             


Thr Val   Lys Glu Ile Ser Lys   Asp Ser Ala Tyr Val   Thr Trp Glu 
    13490                 13495                 13500             


Pro Pro   Ile Ile Asp Gly Gly   Ser Pro Ile Ile Asn   Tyr Val Val 
    13505                 13510                 13515             


Gln Lys   Arg Asp Ala Glu Arg   Lys Ser Trp Ser Thr   Val Thr Thr 
    13520                 13525                 13530             


Glu Cys   Ser Lys Thr Ser Phe   Arg Val Ala Asn Leu   Glu Glu Gly 
    13535                 13540                 13545             


Lys Ser   Tyr Phe Phe Arg Val   Phe Ala Glu Asn Glu   Tyr Gly Ile 
    13550                 13555                 13560             


Gly Asp   Pro Gly Glu Thr Arg   Asp Ala Val Lys Ala   Ser Gln Thr 
    13565                 13570                 13575             


Pro Gly   Pro Val Val Asp Leu   Lys Val Arg Ser Val   Ser Lys Ser 
    13580                 13585                 13590             


Ser Cys   Ser Ile Gly Trp Lys   Lys Pro His Ser Asp   Gly Gly Ser 
    13595                 13600                 13605             


Arg Ile   Ile Gly Tyr Val Val   Asp Phe Leu Thr Glu   Glu Asn Lys 
    13610                 13615                 13620             


Trp Gln   Arg Val Met Lys Ser   Leu Ser Leu Gln Tyr   Ser Ala Lys 
    13625                 13630                 13635             


Asp Leu   Thr Glu Gly Lys Glu   Tyr Thr Phe Arg Val   Ser Ala Glu 
    13640                 13645                 13650             


Asn Glu   Asn Gly Glu Gly Thr   Pro Ser Glu Ile Thr   Val Val Ala 
    13655                 13660                 13665             


Arg Asp   Asp Val Val Ala Pro   Asp Leu Asp Leu Lys   Gly Leu Pro 
    13670                 13675                 13680             


Asp Leu   Cys Tyr Leu Ala Lys   Glu Asn Ser Asn Phe   Arg Leu Lys 
    13685                 13690                 13695             


Ile Pro   Ile Lys Gly Lys Pro   Ala Pro Ser Val Ser   Trp Lys Lys 
    13700                 13705                 13710             


Gly Glu   Asp Pro Leu Ala Thr   Asp Thr Arg Val Ser   Val Glu Ser 
    13715                 13720                 13725             


Ser Ala   Val Asn Thr Thr Leu   Ile Val Tyr Asp Cys   Gln Lys Ser 
    13730                 13735                 13740             


Asp Ala   Gly Lys Tyr Thr Ile   Thr Leu Lys Asn Val   Ala Gly Thr 
    13745                 13750                 13755             


Lys Glu   Gly Thr Ile Ser Ile   Lys Val Val Gly Lys   Pro Gly Ile 
    13760                 13765                 13770             


Pro Thr   Gly Pro Ile Lys Phe   Asp Glu Val Thr Ala   Glu Ala Met 
    13775                 13780                 13785             


Thr Leu   Lys Trp Ala Pro Pro   Lys Asp Asp Gly Gly   Ser Glu Ile 
    13790                 13795                 13800             


Thr Asn   Tyr Ile Leu Glu Lys   Arg Asp Ser Val Asn   Asn Lys Trp 
    13805                 13810                 13815             


Val Thr   Cys Ala Ser Ala Val   Gln Lys Thr Thr Phe   Arg Val Thr 
    13820                 13825                 13830             


Arg Leu   His Glu Gly Met Glu   Tyr Thr Phe Arg Val   Ser Ala Glu 
    13835                 13840                 13845             


Asn Lys   Tyr Gly Val Gly Glu   Gly Leu Lys Ser Glu   Pro Ile Val 
    13850                 13855                 13860             


Ala Arg   His Pro Phe Asp Val   Pro Asp Ala Pro Pro   Pro Pro Asn 
    13865                 13870                 13875             


Ile Val   Asp Val Arg His Asp   Ser Val Ser Leu Thr   Trp Thr Asp 
    13880                 13885                 13890             


Pro Lys   Lys Thr Gly Gly Ser   Pro Ile Thr Gly Tyr   His Leu Glu 
    13895                 13900                 13905             


Phe Lys   Glu Arg Asn Ser Leu   Leu Trp Lys Arg Ala   Asn Lys Thr 
    13910                 13915                 13920             


Pro Ile   Arg Met Arg Asp Phe   Lys Val Thr Gly Leu   Thr Glu Gly 
    13925                 13930                 13935             


Leu Glu   Tyr Glu Phe Arg Val   Met Ala Ile Asn Leu   Ala Gly Val 
    13940                 13945                 13950             


Gly Lys   Pro Ser Leu Pro Ser   Glu Pro Val Val Ala   Leu Asp Pro 
    13955                 13960                 13965             


Ile Asp   Pro Pro Gly Lys Pro   Glu Val Ile Asn Ile   Thr Arg Asn 
    13970                 13975                 13980             


Ser Val   Thr Leu Ile Trp Thr   Glu Pro Lys Tyr Asp   Gly Gly His 
    13985                 13990                 13995             


Lys Leu   Thr Gly Tyr Ile Val   Glu Lys Arg Asp Leu   Pro Ser Lys 
    14000                 14005                 14010             


Ser Trp   Met Lys Ala Asn His   Val Asn Val Pro Glu   Cys Ala Phe 
    14015                 14020                 14025             


Thr Val   Thr Asp Leu Val Glu   Gly Gly Lys Tyr Glu   Phe Arg Ile 
    14030                 14035                 14040             


Arg Ala   Lys Asn Thr Ala Gly   Ala Ile Ser Ala Pro   Ser Glu Ser 
    14045                 14050                 14055             


Thr Glu   Thr Ile Ile Cys Lys   Asp Glu Tyr Glu Ala   Pro Thr Ile 
    14060                 14065                 14070             


Val Leu   Asp Pro Thr Ile Lys   Asp Gly Leu Thr Ile   Lys Ala Gly 
    14075                 14080                 14085             


Asp Thr   Ile Val Leu Asn Ala   Ile Ser Ile Leu Gly   Lys Pro Leu 
    14090                 14095                 14100             


Pro Lys   Ser Ser Trp Ser Lys   Ala Gly Lys Asp Ile   Arg Pro Ser 
    14105                 14110                 14115             


Asp Ile   Thr Gln Ile Thr Ser   Thr Pro Thr Ser Ser   Met Leu Thr 
    14120                 14125                 14130             


Ile Lys   Tyr Ala Thr Arg Lys   Asp Ala Gly Glu Tyr   Thr Ile Thr 
    14135                 14140                 14145             


Ala Thr   Asn Pro Phe Gly Thr   Lys Val Glu His Val   Lys Val Thr 
    14150                 14155                 14160             


Val Leu   Asp Val Pro Gly Pro   Pro Gly Pro Val Glu   Ile Ser Asn 
    14165                 14170                 14175             


Val Ser   Ala Glu Lys Ala Thr   Leu Thr Trp Thr Pro   Pro Leu Glu 
    14180                 14185                 14190             


Asp Gly   Gly Ser Pro Ile Lys   Ser Tyr Ile Leu Glu   Lys Arg Glu 
    14195                 14200                 14205             


Thr Ser   Arg Leu Leu Trp Thr   Val Val Ser Glu Asp   Ile Gln Ser 
    14210                 14215                 14220             


Cys Arg   His Val Ala Thr Lys   Leu Ile Gln Gly Asn   Glu Tyr Ile 
    14225                 14230                 14235             


Phe Arg   Val Ser Ala Val Asn   His Tyr Gly Lys Gly   Glu Pro Val 
    14240                 14245                 14250             


Gln Ser   Glu Pro Val Lys Met   Val Asp Arg Phe Gly   Pro Pro Gly 
    14255                 14260                 14265             


Pro Pro   Glu Lys Pro Glu Val   Ser Asn Val Thr Lys   Asn Thr Ala 
    14270                 14275                 14280             


Thr Val   Ser Trp Lys Arg Pro   Val Asp Asp Gly Gly   Ser Glu Ile 
    14285                 14290                 14295             


Thr Gly   Tyr His Val Glu Arg   Arg Glu Lys Lys Ser   Leu Arg Trp 
    14300                 14305                 14310             


Val Arg   Ala Ile Lys Thr Pro   Val Ser Asp Leu Arg   Cys Lys Val 
    14315                 14320                 14325             


Thr Gly   Leu Gln Glu Gly Ser   Thr Tyr Glu Phe Arg   Val Ser Ala 
    14330                 14335                 14340             


Glu Asn   Arg Ala Gly Ile Gly   Pro Pro Ser Glu Ala   Ser Asp Ser 
    14345                 14350                 14355             


Val Leu   Met Lys Asp Ala Ala   Tyr Pro Pro Gly Pro   Pro Ser Asn 
    14360                 14365                 14370             


Pro His   Val Thr Asp Thr Thr   Lys Lys Ser Ala Ser   Leu Ala Trp 
    14375                 14380                 14385             


Gly Lys   Pro His Tyr Asp Gly   Gly Leu Glu Ile Thr   Gly Tyr Val 
    14390                 14395                 14400             


Val Glu   His Gln Lys Val Gly   Asp Glu Ala Trp Ile   Lys Asp Thr 
    14405                 14410                 14415             


Thr Gly   Thr Ala Leu Arg Ile   Thr Gln Phe Val Val   Pro Asp Leu 
    14420                 14425                 14430             


Gln Thr   Lys Glu Lys Tyr Asn   Phe Arg Ile Ser Ala   Ile Asn Asp 
    14435                 14440                 14445             


Ala Gly   Val Gly Glu Pro Ala   Val Ile Pro Asp Val   Glu Ile Val 
    14450                 14455                 14460             


Glu Arg   Glu Met Ala Pro Asp   Phe Glu Leu Asp Ala   Glu Leu Arg 
    14465                 14470                 14475             


Arg Thr   Leu Val Val Arg Ala   Gly Leu Ser Ile Arg   Ile Phe Val 
    14480                 14485                 14490             


Pro Ile   Lys Gly Arg Pro Ala   Pro Glu Val Thr Trp   Thr Lys Asp 
    14495                 14500                 14505             


Asn Ile   Asn Leu Lys Asn Arg   Ala Asn Ile Glu Asn   Thr Glu Ser 
    14510                 14515                 14520             


Phe Thr   Leu Leu Ile Ile Pro   Glu Cys Asn Arg Tyr   Asp Thr Gly 
    14525                 14530                 14535             


Lys Phe   Val Met Thr Ile Glu   Asn Pro Ala Gly Lys   Lys Ser Gly 
    14540                 14545                 14550             


Phe Val   Asn Val Arg Val Leu   Asp Thr Pro Gly Pro   Val Leu Asn 
    14555                 14560                 14565             


Leu Arg   Pro Thr Asp Ile Thr   Lys Asp Ser Val Thr   Leu His Trp 
    14570                 14575                 14580             


Asp Leu   Pro Leu Ile Asp Gly   Gly Ser Arg Ile Thr   Asn Tyr Ile 
    14585                 14590                 14595             


Val Glu   Lys Arg Glu Ala Thr   Arg Lys Ser Tyr Ser   Thr Ala Thr 
    14600                 14605                 14610             


Thr Lys   Cys His Lys Cys Thr   Tyr Lys Val Thr Gly   Leu Ser Glu 
    14615                 14620                 14625             


Gly Cys   Glu Tyr Phe Phe Arg   Val Met Ala Glu Asn   Glu Tyr Gly 
    14630                 14635                 14640             


Ile Gly   Glu Pro Thr Glu Thr   Thr Glu Pro Val Lys   Ala Ser Glu 
    14645                 14650                 14655             


Ala Pro   Ser Pro Pro Asp Ser   Leu Asn Ile Met Asp   Ile Thr Lys 
    14660                 14665                 14670             


Ser Thr   Val Ser Leu Ala Trp   Pro Lys Pro Lys His   Asp Gly Gly 
    14675                 14680                 14685             


Ser Lys   Ile Thr Gly Tyr Val   Ile Glu Ala Gln Arg   Lys Gly Ser 
    14690                 14695                 14700             


Asp Gln   Trp Thr His Ile Thr   Thr Val Lys Gly Leu   Glu Cys Val 
    14705                 14710                 14715             


Val Arg   Asn Leu Thr Glu Gly   Glu Glu Tyr Thr Phe   Gln Val Met 
    14720                 14725                 14730             


Ala Val   Asn Ser Ala Gly Arg   Ser Ala Pro Arg Glu   Ser Arg Pro 
    14735                 14740                 14745             


Val Ile   Val Lys Glu Gln Thr   Met Leu Pro Glu Leu   Asp Leu Arg 
    14750                 14755                 14760             


Gly Ile   Tyr Gln Lys Leu Val   Ile Ala Lys Ala Gly   Asp Asn Ile 
    14765                 14770                 14775             


Lys Val   Glu Ile Pro Val Leu   Gly Arg Pro Lys Pro   Thr Val Thr 
    14780                 14785                 14790             


Trp Lys   Lys Gly Asp Gln Ile   Leu Lys Gln Thr Gln   Arg Val Asn 
    14795                 14800                 14805             


Phe Glu   Thr Thr Ala Thr Ser   Thr Ile Leu Asn Ile   Asn Glu Cys 
    14810                 14815                 14820             


Val Arg   Ser Asp Ser Gly Pro   Tyr Pro Leu Thr Ala   Arg Asn Ile 
    14825                 14830                 14835             


Val Gly   Glu Val Gly Asp Val   Ile Thr Ile Gln Val   His Asp Ile 
    14840                 14845                 14850             


Pro Gly   Pro Pro Thr Gly Pro   Ile Lys Phe Asp Glu   Val Ser Ser 
    14855                 14860                 14865             


Asp Phe   Val Thr Phe Ser Trp   Asp Pro Pro Glu Asn   Asp Gly Gly 
    14870                 14875                 14880             


Val Pro   Ile Ser Asn Tyr Val   Val Glu Met Arg Gln   Thr Asp Ser 
    14885                 14890                 14895             


Thr Thr   Trp Val Glu Leu Ala   Thr Thr Val Ile Arg   Thr Thr Tyr 
    14900                 14905                 14910             


Lys Ala   Thr Arg Leu Thr Thr   Gly Leu Glu Tyr Gln   Phe Arg Val 
    14915                 14920                 14925             


Lys Ala   Gln Asn Arg Tyr Gly   Val Gly Pro Gly Ile   Thr Ser Ala 
    14930                 14935                 14940             


Cys Ile   Val Ala Asn Tyr Pro   Phe Lys Val Pro Gly   Pro Pro Gly 
    14945                 14950                 14955             


Thr Pro   Gln Val Thr Ala Val   Thr Lys Asp Ser Met   Thr Ile Ser 
    14960                 14965                 14970             


Trp His   Glu Pro Leu Ser Asp   Gly Gly Ser Pro Ile   Leu Gly Tyr 
    14975                 14980                 14985             


His Val   Glu Arg Lys Glu Arg   Asn Gly Ile Leu Trp   Gln Thr Val 
    14990                 14995                 15000             


Ser Lys   Ala Leu Val Pro Gly   Asn Ile Phe Lys Ser   Ser Gly Leu 
    15005                 15010                 15015             


Thr Asp   Gly Ile Ala Tyr Glu   Phe Arg Val Ile Ala   Glu Asn Met 
    15020                 15025                 15030             


Ala Gly   Lys Ser Lys Pro Ser   Lys Pro Ser Glu Pro   Met Leu Ala 
    15035                 15040                 15045             


Leu Asp   Pro Ile Asp Pro Pro   Gly Lys Pro Val Pro   Leu Asn Ile 
    15050                 15055                 15060             


Thr Arg   His Thr Val Thr Leu   Lys Trp Ala Lys Pro   Glu Tyr Thr 
    15065                 15070                 15075             


Gly Gly   Phe Lys Ile Thr Ser   Tyr Ile Val Glu Lys   Arg Asp Leu 
    15080                 15085                 15090             


Pro Asn   Gly Arg Trp Leu Lys   Ala Asn Phe Ser Asn   Ile Leu Glu 
    15095                 15100                 15105             


Asn Glu   Phe Thr Val Ser Gly   Leu Thr Glu Asp Ala   Ala Tyr Glu 
    15110                 15115                 15120             


Phe Arg   Val Ile Ala Lys Asn   Ala Ala Gly Ala Ile   Ser Pro Pro 
    15125                 15130                 15135             


Ser Glu   Pro Ser Asp Ala Ile   Thr Cys Arg Asp Asp   Val Glu Ala 
    15140                 15145                 15150             


Pro Lys   Ile Lys Val Asp Val   Lys Phe Lys Asp Thr   Val Ile Leu 
    15155                 15160                 15165             


Lys Ala   Gly Glu Ala Phe Arg   Leu Glu Ala Asp Val   Ser Gly Arg 
    15170                 15175                 15180             


Pro Pro   Pro Thr Met Glu Trp   Ser Lys Asp Gly Lys   Glu Leu Glu 
    15185                 15190                 15195             


Gly Thr   Ala Lys Leu Glu Ile   Lys Ile Ala Asp Phe   Ser Thr Asn 
    15200                 15205                 15210             


Leu Val   Asn Lys Asp Ser Thr   Arg Arg Asp Ser Gly   Ala Tyr Thr 
    15215                 15220                 15225             


Leu Thr   Ala Thr Asn Pro Gly   Gly Phe Ala Lys His   Ile Phe Asn 
    15230                 15235                 15240             


Val Lys   Val Leu Asp Arg Pro   Gly Pro Pro Glu Gly   Pro Leu Ala 
    15245                 15250                 15255             


Val Thr   Glu Val Thr Ser Glu   Lys Cys Val Leu Ser   Trp Phe Pro 
    15260                 15265                 15270             


Pro Leu   Asp Asp Gly Gly Ala   Lys Ile Asp His Tyr   Ile Val Gln 
    15275                 15280                 15285             


Lys Arg   Glu Thr Ser Arg Leu   Ala Trp Thr Asn Val   Ala Ser Glu 
    15290                 15295                 15300             


Val Gln   Val Thr Lys Leu Lys   Val Thr Lys Leu Leu   Lys Gly Asn 
    15305                 15310                 15315             


Glu Tyr   Ile Phe Arg Val Met   Ala Val Asn Lys Tyr   Gly Val Gly 
    15320                 15325                 15330             


Glu Pro   Leu Glu Ser Glu Pro   Val Leu Ala Val Asn   Pro Tyr Gly 
    15335                 15340                 15345             


Pro Pro   Asp Pro Pro Lys Asn   Pro Glu Val Thr Thr   Ile Thr Lys 
    15350                 15355                 15360             


Asp Ser   Met Val Val Cys Trp   Gly His Pro Asp Ser   Asp Gly Gly 
    15365                 15370                 15375             


Ser Glu   Ile Ile Asn Tyr Ile   Val Glu Arg Arg Asp   Lys Ala Gly 
    15380                 15385                 15390             


Gln Arg   Trp Ile Lys Cys Asn   Lys Lys Thr Leu Thr   Asp Leu Arg 
    15395                 15400                 15405             


Tyr Lys   Val Ser Gly Leu Thr   Glu Gly His Glu Tyr   Glu Phe Arg 
    15410                 15415                 15420             


Ile Met   Ala Glu Asn Ala Ala   Gly Ile Ser Ala Pro   Ser Pro Thr 
    15425                 15430                 15435             


Ser Pro   Phe Tyr Lys Ala Cys   Asp Thr Val Phe Lys   Pro Gly Pro 
    15440                 15445                 15450             


Pro Gly   Asn Pro Arg Val Leu   Asp Thr Ser Arg Ser   Ser Ile Ser 
    15455                 15460                 15465             


Ile Ala   Trp Asn Lys Pro Ile   Tyr Asp Gly Gly Ser   Glu Ile Thr 
    15470                 15475                 15480             


Gly Tyr   Met Val Glu Ile Ala   Leu Pro Glu Glu Asp   Glu Trp Gln 
    15485                 15490                 15495             


Ile Val   Thr Pro Pro Ala Gly   Leu Lys Ala Thr Ser   Tyr Thr Ile 
    15500                 15505                 15510             


Thr Gly   Leu Thr Glu Asn Gln   Glu Tyr Lys Ile Arg   Ile Tyr Ala 
    15515                 15520                 15525             


Met Asn   Ser Glu Gly Leu Gly   Glu Pro Ala Leu Val   Pro Gly Thr 
    15530                 15535                 15540             


Pro Lys   Ala Glu Asp Arg Met   Leu Pro Pro Glu Ile   Glu Leu Asp 
    15545                 15550                 15555             


Ala Asp   Leu Arg Lys Val Val   Thr Ile Arg Ala Cys   Cys Thr Leu 
    15560                 15565                 15570             


Arg Leu   Phe Val Pro Ile Lys   Gly Arg Pro Ala Pro   Glu Val Lys 
    15575                 15580                 15585             


Trp Ala   Arg Asp His Gly Glu   Ser Leu Asp Lys Ala   Ser Ile Glu 
    15590                 15595                 15600             


Ser Thr   Ser Ser Tyr Thr Leu   Leu Ile Val Gly Asn   Val Asn Arg 
    15605                 15610                 15615             


Phe Asp   Ser Gly Lys Tyr Ile   Leu Thr Val Glu Asn   Ser Ser Gly 
    15620                 15625                 15630             


Ser Lys   Ser Ala Phe Val Asn   Val Arg Val Leu Asp   Thr Pro Gly 
    15635                 15640                 15645             


Pro Pro   Gln Asp Leu Lys Val   Lys Glu Val Thr Lys   Thr Ser Val 
    15650                 15655                 15660             


Thr Leu   Thr Trp Asp Pro Pro   Leu Leu Asp Gly Gly   Ser Lys Ile 
    15665                 15670                 15675             


Lys Asn   Tyr Ile Val Glu Lys   Arg Glu Ser Thr Arg   Lys Ala Tyr 
    15680                 15685                 15690             


Ser Thr   Val Ala Thr Asn Cys   His Lys Thr Ser Trp   Lys Val Asp 
    15695                 15700                 15705             


Gln Leu   Gln Glu Gly Cys Ser   Tyr Tyr Phe Arg Val   Leu Ala Glu 
    15710                 15715                 15720             


Asn Glu   Tyr Gly Ile Gly Leu   Pro Ala Glu Thr Ala   Glu Ser Val 
    15725                 15730                 15735             


Lys Ala   Ser Glu Arg Pro Leu   Pro Pro Gly Lys Ile   Thr Leu Met 
    15740                 15745                 15750             


Asp Val   Thr Arg Asn Ser Val   Ser Leu Ser Trp Glu   Lys Pro Glu 
    15755                 15760                 15765             


His Asp   Gly Gly Ser Arg Ile   Leu Gly Tyr Ile Val   Glu Met Gln 
    15770                 15775                 15780             


Thr Lys   Gly Ser Asp Lys Trp   Ala Thr Cys Ala Thr   Val Lys Val 
    15785                 15790                 15795             


Thr Glu   Ala Thr Ile Thr Gly   Leu Ile Gln Gly Glu   Glu Tyr Ser 
    15800                 15805                 15810             


Phe Arg   Val Ser Ala Gln Asn   Glu Lys Gly Ile Ser   Asp Pro Arg 
    15815                 15820                 15825             


Gln Leu   Ser Val Pro Val Ile   Ala Lys Asp Leu Val   Ile Pro Pro 
    15830                 15835                 15840             


Ala Phe   Lys Leu Leu Phe Asn   Thr Phe Thr Val Leu   Ala Gly Glu 
    15845                 15850                 15855             


Asp Leu   Lys Val Asp Val Pro   Phe Ile Gly Arg Pro   Thr Pro Ala 
    15860                 15865                 15870             


Val Thr   Trp His Lys Asp Asn   Val Pro Leu Lys Gln   Thr Thr Arg 
    15875                 15880                 15885             


Val Asn   Ala Glu Ser Thr Glu   Asn Asn Ser Leu Leu   Thr Ile Lys 
    15890                 15895                 15900             


Asp Ala   Cys Arg Glu Asp Val   Gly His Tyr Val Val   Lys Leu Thr 
    15905                 15910                 15915             


Asn Ser   Ala Gly Glu Ala Ile   Glu Thr Leu Asn Val   Ile Val Leu 
    15920                 15925                 15930             


Asp Lys   Pro Gly Pro Pro Thr   Gly Pro Val Lys Met   Asp Glu Val 
    15935                 15940                 15945             


Thr Ala   Asp Ser Ile Thr Leu   Ser Trp Gly Pro Pro   Lys Tyr Asp 
    15950                 15955                 15960             


Gly Gly   Ser Ser Ile Asn Asn   Tyr Ile Val Glu Lys   Arg Asp Thr 
    15965                 15970                 15975             


Ser Thr   Thr Thr Trp Gln Ile   Val Ser Ala Thr Val   Ala Arg Thr 
    15980                 15985                 15990             


Thr Ile   Lys Ala Cys Arg Leu   Lys Thr Gly Cys Glu   Tyr Gln Phe 
    15995                 16000                 16005             


Arg Ile   Ala Ala Glu Asn Arg   Tyr Gly Lys Ser Thr   Tyr Leu Asn 
    16010                 16015                 16020             


Ser Glu   Pro Thr Val Ala Gln   Tyr Pro Phe Lys Val   Pro Gly Pro 
    16025                 16030                 16035             


Pro Gly   Thr Pro Val Val Thr   Leu Ser Ser Arg Asp   Ser Met Glu 
    16040                 16045                 16050             


Val Gln   Trp Asn Glu Pro Ile   Ser Asp Gly Gly Ser   Arg Val Ile 
    16055                 16060                 16065             


Gly Tyr   His Leu Glu Arg Lys   Glu Arg Asn Ser Ile   Leu Trp Val 
    16070                 16075                 16080             


Lys Leu   Asn Lys Thr Pro Ile   Pro Gln Thr Lys Phe   Lys Thr Thr 
    16085                 16090                 16095             


Gly Leu   Glu Glu Gly Val Glu   Tyr Glu Phe Arg Val   Ser Ala Glu 
    16100                 16105                 16110             


Asn Ile   Val Gly Ile Gly Lys   Pro Ser Lys Val Ser   Glu Cys Tyr 
    16115                 16120                 16125             


Val Ala   Arg Asp Pro Cys Asp   Pro Pro Gly Arg Pro   Glu Ala Ile 
    16130                 16135                 16140             


Ile Val   Thr Arg Asn Ser Val   Thr Leu Gln Trp Lys   Lys Pro Thr 
    16145                 16150                 16155             


Tyr Asp   Gly Gly Ser Lys Ile   Thr Gly Tyr Ile Val   Glu Lys Lys 
    16160                 16165                 16170             


Glu Leu   Pro Glu Gly Arg Trp   Met Lys Ala Ser Phe   Thr Asn Ile 
    16175                 16180                 16185             


Ile Asp   Thr His Phe Glu Val   Thr Gly Leu Val Glu   Asp His Arg 
    16190                 16195                 16200             


Tyr Glu   Phe Arg Val Ile Ala   Arg Asn Ala Ala Gly   Val Phe Ser 
    16205                 16210                 16215             


Glu Pro   Ser Glu Ser Thr Gly   Ala Ile Thr Ala Arg   Asp Glu Val 
    16220                 16225                 16230             


Asp Pro   Pro Arg Ile Ser Met   Asp Pro Lys Tyr Lys   Asp Thr Ile 
    16235                 16240                 16245             


Val Val   His Ala Gly Glu Ser   Phe Lys Val Asp Ala   Asp Ile Tyr 
    16250                 16255                 16260             


Gly Lys   Pro Ile Pro Thr Ile   Gln Trp Ile Lys Gly   Asp Gln Glu 
    16265                 16270                 16275             


Leu Ser   Asn Thr Ala Arg Leu   Glu Ile Lys Ser Thr   Asp Phe Ala 
    16280                 16285                 16290             


Thr Ser   Leu Ser Val Lys Asp   Ala Val Arg Val Asp   Ser Gly Asn 
    16295                 16300                 16305             


Tyr Ile   Leu Lys Ala Lys Asn   Val Ala Gly Glu Arg   Ser Val Thr 
    16310                 16315                 16320             


Val Asn   Val Lys Val Leu Asp   Arg Pro Gly Pro Pro   Glu Gly Pro 
    16325                 16330                 16335             


Val Val   Ile Ser Gly Val Thr   Ala Glu Lys Cys Thr   Leu Ala Trp 
    16340                 16345                 16350             


Lys Pro   Pro Leu Gln Asp Gly   Gly Ser Asp Ile Ile   Asn Tyr Ile 
    16355                 16360                 16365             


Val Glu   Arg Arg Glu Thr Ser   Arg Leu Val Trp Thr   Val Val Asp 
    16370                 16375                 16380             


Ala Asn   Val Gln Thr Leu Ser   Cys Lys Val Thr Lys   Leu Leu Glu 
    16385                 16390                 16395             


Gly Asn   Glu Tyr Thr Phe Arg   Ile Met Ala Val Asn   Lys Tyr Gly 
    16400                 16405                 16410             


Val Gly   Glu Pro Leu Glu Ser   Glu Pro Val Val Ala   Lys Asn Pro 
    16415                 16420                 16425             


Phe Val   Val Pro Asp Ala Pro   Lys Ala Pro Glu Val   Thr Thr Val 
    16430                 16435                 16440             


Thr Lys   Asp Ser Met Ile Val   Val Trp Glu Arg Pro   Ala Ser Asp 
    16445                 16450                 16455             


Gly Gly   Ser Glu Ile Leu Gly   Tyr Val Leu Glu Lys   Arg Asp Lys 
    16460                 16465                 16470             


Glu Gly   Ile Arg Trp Thr Arg   Cys His Lys Arg Leu   Ile Gly Glu 
    16475                 16480                 16485             


Leu Arg   Leu Arg Val Thr Gly   Leu Ile Glu Asn His   Asp Tyr Glu 
    16490                 16495                 16500             


Phe Arg   Val Ser Ala Glu Asn   Ala Ala Gly Leu Ser   Glu Pro Ser 
    16505                 16510                 16515             


Pro Pro   Ser Ala Tyr Gln Lys   Ala Cys Asp Pro Ile   Tyr Lys Pro 
    16520                 16525                 16530             


Gly Pro   Pro Asn Asn Pro Lys   Val Ile Asp Ile Thr   Arg Ser Ser 
    16535                 16540                 16545             


Val Phe   Leu Ser Trp Ser Lys   Pro Ile Tyr Asp Gly   Gly Cys Glu 
    16550                 16555                 16560             


Ile Gln   Gly Tyr Ile Val Glu   Lys Cys Asp Val Ser   Val Gly Glu 
    16565                 16570                 16575             


Trp Thr   Met Cys Thr Pro Pro   Thr Gly Ile Asn Lys   Thr Asn Ile 
    16580                 16585                 16590             


Glu Val   Glu Lys Leu Leu Glu   Lys His Glu Tyr Asn   Phe Arg Ile 
    16595                 16600                 16605             


Cys Ala   Ile Asn Lys Ala Gly   Val Gly Glu His Ala   Asp Val Pro 
    16610                 16615                 16620             


Gly Pro   Ile Ile Val Glu Glu   Lys Leu Glu Ala Pro   Asp Ile Asp 
    16625                 16630                 16635             


Leu Asp   Leu Glu Leu Arg Lys   Ile Ile Asn Ile Arg   Ala Gly Gly 
    16640                 16645                 16650             


Ser Leu   Arg Leu Phe Val Pro   Ile Lys Gly Arg Pro   Thr Pro Glu 
    16655                 16660                 16665             


Val Lys   Trp Gly Lys Val Asp   Gly Glu Ile Arg Asp   Ala Ala Ile 
    16670                 16675                 16680             


Ile Asp   Val Thr Ser Ser Phe   Thr Ser Leu Val Leu   Asp Asn Val 
    16685                 16690                 16695             


Asn Arg   Tyr Asp Ser Gly Lys   Tyr Thr Leu Thr Leu   Glu Asn Ser 
    16700                 16705                 16710             


Ser Gly   Thr Lys Ser Ala Phe   Val Thr Val Arg Val   Leu Asp Thr 
    16715                 16720                 16725             


Pro Ser   Pro Pro Val Asn Leu   Lys Val Thr Glu Ile   Thr Lys Asp 
    16730                 16735                 16740             


Ser Val   Ser Ile Thr Trp Glu   Pro Pro Leu Leu Asp   Gly Gly Ser 
    16745                 16750                 16755             


Lys Ile   Lys Asn Tyr Ile Val   Glu Lys Arg Glu Ala   Thr Arg Lys 
    16760                 16765                 16770             


Ser Tyr   Ala Ala Val Val Thr   Asn Cys His Lys Asn   Ser Trp Lys 
    16775                 16780                 16785             


Ile Asp   Gln Leu Gln Glu Gly   Cys Ser Tyr Tyr Phe   Arg Val Thr 
    16790                 16795                 16800             


Ala Glu   Asn Glu Tyr Gly Ile   Gly Leu Pro Ala Gln   Thr Ala Asp 
    16805                 16810                 16815             


Pro Ile   Lys Val Ala Glu Val   Pro Gln Pro Pro Gly   Lys Ile Thr 
    16820                 16825                 16830             


Val Asp   Asp Val Thr Arg Asn   Ser Val Ser Leu Ser   Trp Thr Lys 
    16835                 16840                 16845             


Pro Glu   His Asp Gly Gly Ser   Lys Ile Ile Gln Tyr   Ile Val Glu 
    16850                 16855                 16860             


Met Gln   Ala Lys His Ser Glu   Lys Trp Ser Glu Cys   Ala Arg Val 
    16865                 16870                 16875             


Lys Ser   Leu Gln Ala Val Ile   Thr Asn Leu Thr Gln   Gly Glu Glu 
    16880                 16885                 16890             


Tyr Leu   Phe Arg Val Val Ala   Val Asn Glu Lys Gly   Arg Ser Asp 
    16895                 16900                 16905             


Pro Arg   Ser Leu Ala Val Pro   Ile Val Ala Lys Asp   Leu Val Ile 
    16910                 16915                 16920             


Glu Pro   Asp Val Lys Pro Ala   Phe Ser Ser Tyr Ser   Val Gln Val 
    16925                 16930                 16935             


Gly Gln   Asp Leu Lys Ile Glu   Val Pro Ile Ser Gly   Arg Pro Lys 
    16940                 16945                 16950             


Pro Thr   Ile Thr Trp Thr Lys   Asp Gly Leu Pro Leu   Lys Gln Thr 
    16955                 16960                 16965             


Thr Arg   Ile Asn Val Thr Asp   Ser Leu Asp Leu Thr   Thr Leu Ser 
    16970                 16975                 16980             


Ile Lys   Glu Thr His Lys Asp   Asp Gly Gly Gln Tyr   Gly Ile Thr 
    16985                 16990                 16995             


Val Ala   Asn Val Val Gly Gln   Lys Thr Ala Ser Ile   Glu Ile Val 
    17000                 17005                 17010             


Thr Leu   Asp Lys Pro Asp Pro   Pro Lys Gly Pro Val   Lys Phe Asp 
    17015                 17020                 17025             


Asp Val   Ser Ala Glu Ser Ile   Thr Leu Ser Trp Asn   Pro Pro Leu 
    17030                 17035                 17040             


Tyr Thr   Gly Gly Cys Gln Ile   Thr Asn Tyr Ile Val   Gln Lys Arg 
    17045                 17050                 17055             


Asp Thr   Thr Thr Thr Val Trp   Asp Val Val Ser Ala   Thr Val Ala 
    17060                 17065                 17070             


Arg Thr   Thr Leu Lys Val Thr   Lys Leu Lys Thr Gly   Thr Glu Tyr 
    17075                 17080                 17085             


Gln Phe   Arg Ile Phe Ala Glu   Asn Arg Tyr Gly Gln   Ser Phe Ala 
    17090                 17095                 17100             


Leu Glu   Ser Asp Pro Ile Val   Ala Gln Tyr Pro Tyr   Lys Glu Pro 
    17105                 17110                 17115             


Gly Pro   Pro Gly Thr Pro Phe   Ala Thr Ala Ile Ser   Lys Asp Ser 
    17120                 17125                 17130             


Met Val   Ile Gln Trp His Glu   Pro Val Asn Asn Gly   Gly Ser Pro 
    17135                 17140                 17145             


Val Ile   Gly Tyr His Leu Glu   Arg Lys Glu Arg Asn   Ser Ile Leu 
    17150                 17155                 17160             


Trp Thr   Lys Val Asn Lys Thr   Ile Ile His Asp Thr   Gln Phe Lys 
    17165                 17170                 17175             


Ala Gln   Asn Leu Glu Glu Gly   Ile Glu Tyr Glu Phe   Arg Val Tyr 
    17180                 17185                 17190             


Ala Glu   Asn Ile Val Gly Val   Gly Lys Ala Ser Lys   Asn Ser Glu 
    17195                 17200                 17205             


Cys Tyr   Val Ala Arg Asp Pro   Cys Asp Pro Pro Gly   Thr Pro Glu 
    17210                 17215                 17220             


Pro Ile   Met Val Lys Arg Asn   Glu Ile Thr Leu Gln   Trp Thr Lys 
    17225                 17230                 17235             


Pro Val   Tyr Asp Gly Gly Ser   Met Ile Thr Gly Tyr   Ile Val Glu 
    17240                 17245                 17250             


Lys Arg   Asp Leu Pro Asp Gly   Arg Trp Met Lys Ala   Ser Phe Thr 
    17255                 17260                 17265             


Asn Val   Ile Glu Thr Gln Phe   Thr Val Ser Gly Leu   Thr Glu Asp 
    17270                 17275                 17280             


Gln Arg   Tyr Glu Phe Arg Val   Ile Ala Lys Asn Ala   Ala Gly Ala 
    17285                 17290                 17295             


Ile Ser   Lys Pro Ser Asp Ser   Thr Gly Pro Ile Thr   Ala Lys Asp 
    17300                 17305                 17310             


Glu Val   Glu Leu Pro Arg Ile   Ser Met Asp Pro Lys   Phe Arg Asp 
    17315                 17320                 17325             


Thr Ile   Val Val Asn Ala Gly   Glu Thr Phe Arg Leu   Glu Ala Asp 
    17330                 17335                 17340             


Val His   Gly Lys Pro Leu Pro   Thr Ile Glu Trp Leu   Arg Gly Asp 
    17345                 17350                 17355             


Lys Glu   Ile Glu Glu Ser Ala   Arg Cys Glu Ile Lys   Asn Thr Asp 
    17360                 17365                 17370             


Phe Lys   Ala Leu Leu Ile Val   Lys Asp Ala Ile Arg   Ile Asp Gly 
    17375                 17380                 17385             


Gly Gln   Tyr Ile Leu Arg Ala   Ser Asn Val Ala Gly   Ser Lys Ser 
    17390                 17395                 17400             


Phe Pro   Val Asn Val Lys Val   Leu Asp Arg Pro Gly   Pro Pro Glu 
    17405                 17410                 17415             


Gly Pro   Val Gln Val Thr Gly   Val Thr Ser Glu Lys   Cys Ser Leu 
    17420                 17425                 17430             


Thr Trp   Ser Pro Pro Leu Gln   Asp Gly Gly Ser Asp   Ile Ser His 
    17435                 17440                 17445             


Tyr Val   Val Glu Lys Arg Glu   Thr Ser Arg Leu Ala   Trp Thr Val 
    17450                 17455                 17460             


Val Ala   Ser Glu Val Val Thr   Asn Ser Leu Lys Val   Thr Lys Leu 
    17465                 17470                 17475             


Leu Glu   Gly Asn Glu Tyr Val   Phe Arg Ile Met Ala   Val Asn Lys 
    17480                 17485                 17490             


Tyr Gly   Val Gly Glu Pro Leu   Glu Ser Ala Pro Val   Leu Met Lys 
    17495                 17500                 17505             


Asn Pro   Phe Val Leu Pro Gly   Pro Pro Lys Ser Leu   Glu Val Thr 
    17510                 17515                 17520             


Asn Ile   Ala Lys Asp Ser Met   Thr Val Cys Trp Asn   Arg Pro Asp 
    17525                 17530                 17535             


Ser Asp   Gly Gly Ser Glu Ile   Ile Gly Tyr Ile Val   Glu Lys Arg 
    17540                 17545                 17550             


Asp Arg   Ser Gly Ile Arg Trp   Ile Lys Cys Asn Lys   Arg Arg Ile 
    17555                 17560                 17565             


Thr Asp   Leu Arg Leu Arg Val   Thr Gly Leu Thr Glu   Asp His Glu 
    17570                 17575                 17580             


Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Ala Ala Gly   Val Gly Glu 
    17585                 17590                 17595             


Pro Ser   Pro Ala Thr Val Tyr   Tyr Lys Ala Cys Asp   Pro Val Phe 
    17600                 17605                 17610             


Lys Pro   Gly Pro Pro Thr Asn   Ala His Ile Val Asp   Thr Thr Lys 
    17615                 17620                 17625             


Asn Ser   Ile Thr Leu Ala Trp   Gly Lys Pro Ile Tyr   Asp Gly Gly 
    17630                 17635                 17640             


Ser Glu   Ile Leu Gly Tyr Val   Val Glu Ile Cys Lys   Ala Asp Glu 
    17645                 17650                 17655             


Glu Glu   Trp Gln Ile Val Thr   Pro Gln Thr Gly Leu   Arg Val Thr 
    17660                 17665                 17670             


Arg Phe   Glu Ile Ser Lys Leu   Thr Glu His Gln Glu   Tyr Lys Ile 
    17675                 17680                 17685             


Arg Val   Cys Ala Leu Asn Lys   Val Gly Leu Gly Glu   Ala Thr Ser 
    17690                 17695                 17700             


Val Pro   Gly Thr Val Lys Pro   Glu Asp Lys Leu Glu   Ala Pro Glu 
    17705                 17710                 17715             


Leu Asp   Leu Asp Ser Glu Leu   Arg Lys Gly Ile Val   Val Arg Ala 
    17720                 17725                 17730             


Gly Gly   Ser Ala Arg Ile His   Ile Pro Phe Lys Gly   Arg Pro Thr 
    17735                 17740                 17745             


Pro Glu   Ile Thr Trp Ser Arg   Glu Glu Gly Glu Phe   Thr Asp Lys 
    17750                 17755                 17760             


Val Gln   Ile Glu Lys Gly Val   Asn Tyr Thr Gln Leu   Ser Ile Asp 
    17765                 17770                 17775             


Asn Cys   Asp Arg Asn Asp Ala   Gly Lys Tyr Ile Leu   Lys Leu Glu 
    17780                 17785                 17790             


Asn Ser   Ser Gly Ser Lys Ser   Ala Phe Val Thr Val   Lys Val Leu 
    17795                 17800                 17805             


Asp Thr   Pro Gly Pro Pro Gln   Asn Leu Ala Val Lys   Glu Val Arg 
    17810                 17815                 17820             


Lys Asp   Ser Ala Phe Leu Val   Trp Glu Pro Pro Ile   Ile Asp Gly 
    17825                 17830                 17835             


Gly Ala   Lys Val Lys Asn Tyr   Val Ile Asp Lys Arg   Glu Ser Thr 
    17840                 17845                 17850             


Arg Lys   Ala Tyr Ala Asn Val   Ser Ser Lys Cys Ser   Lys Thr Ser 
    17855                 17860                 17865             


Phe Lys   Val Glu Asn Leu Thr   Glu Gly Ala Ile Tyr   Tyr Phe Arg 
    17870                 17875                 17880             


Val Met   Ala Glu Asn Glu Phe   Gly Val Gly Val Pro   Val Glu Thr 
    17885                 17890                 17895             


Val Asp   Ala Val Lys Ala Ala   Glu Pro Pro Ser Pro   Pro Gly Lys 
    17900                 17905                 17910             


Val Thr   Leu Thr Asp Val Ser   Gln Thr Ser Ala Ser   Leu Met Trp 
    17915                 17920                 17925             


Glu Lys   Pro Glu His Asp Gly   Gly Ser Arg Val Leu   Gly Tyr Val 
    17930                 17935                 17940             


Val Glu   Met Gln Pro Lys Gly   Thr Glu Lys Trp Ser   Ile Val Ala 
    17945                 17950                 17955             


Glu Ser   Lys Val Cys Asn Ala   Val Val Thr Gly Leu   Ser Ser Gly 
    17960                 17965                 17970             


Gln Glu   Tyr Gln Phe Arg Val   Lys Ala Tyr Asn Glu   Lys Gly Lys 
    17975                 17980                 17985             


Ser Asp   Pro Arg Val Leu Gly   Val Pro Val Ile Ala   Lys Asp Leu 
    17990                 17995                 18000             


Thr Ile   Gln Pro Ser Leu Lys   Leu Pro Phe Asn Thr   Tyr Ser Ile 
    18005                 18010                 18015             


Gln Ala   Gly Glu Asp Leu Lys   Ile Glu Ile Pro Val   Ile Gly Arg 
    18020                 18025                 18030             


Pro Arg   Pro Asn Ile Ser Trp   Val Lys Asp Gly Glu   Pro Leu Lys 
    18035                 18040                 18045             


Gln Thr   Thr Arg Val Asn Val   Glu Glu Thr Ala Thr   Ser Thr Val 
    18050                 18055                 18060             


Leu His   Ile Lys Glu Gly Asn   Lys Asp Asp Phe Gly   Lys Tyr Thr 
    18065                 18070                 18075             


Val Thr   Ala Thr Asn Ser Ala   Gly Thr Ala Thr Glu   Asn Leu Ser 
    18080                 18085                 18090             


Val Ile   Val Leu Glu Lys Pro   Gly Pro Pro Val Gly   Pro Val Arg 
    18095                 18100                 18105             


Phe Asp   Glu Val Ser Ala Asp   Phe Val Val Ile Ser   Trp Glu Pro 
    18110                 18115                 18120             


Pro Ala   Tyr Thr Gly Gly Cys   Gln Ile Ser Asn Tyr   Ile Val Glu 
    18125                 18130                 18135             


Lys Arg   Asp Thr Thr Thr Thr   Thr Trp His Met Val   Ser Ala Thr 
    18140                 18145                 18150             


Val Ala   Arg Thr Thr Ile Lys   Ile Thr Lys Leu Lys   Thr Gly Thr 
    18155                 18160                 18165             


Glu Tyr   Gln Phe Arg Ile Phe   Ala Glu Asn Arg Tyr   Gly Lys Ser 
    18170                 18175                 18180             


Ala Pro   Leu Asp Ser Lys Ala   Val Ile Val Gln Tyr   Pro Phe Lys 
    18185                 18190                 18195             


Glu Pro   Gly Pro Pro Gly Thr   Pro Phe Val Thr Ser   Ile Ser Lys 
    18200                 18205                 18210             


Asp Gln   Met Leu Val Gln Trp   His Glu Pro Val Asn   Asp Gly Gly 
    18215                 18220                 18225             


Thr Lys   Ile Ile Gly Tyr His   Leu Glu Gln Lys Glu   Lys Asn Ser 
    18230                 18235                 18240             


Ile Leu   Trp Val Lys Leu Asn   Lys Thr Pro Ile Gln   Asp Thr Lys 
    18245                 18250                 18255             


Phe Lys   Thr Thr Gly Leu Asp   Glu Gly Leu Glu Tyr   Glu Phe Lys 
    18260                 18265                 18270             


Val Ser   Ala Glu Asn Ile Val   Gly Ile Gly Lys Pro   Ser Lys Val 
    18275                 18280                 18285             


Ser Glu   Cys Phe Val Ala Arg   Asp Pro Cys Asp Pro   Pro Gly Arg 
    18290                 18295                 18300             


Pro Glu   Ala Ile Val Ile Thr   Arg Asn Asn Val Thr   Leu Lys Trp 
    18305                 18310                 18315             


Lys Lys   Pro Ala Tyr Asp Gly   Gly Ser Lys Ile Thr   Gly Tyr Ile 
    18320                 18325                 18330             


Val Glu   Lys Lys Asp Leu Pro   Asp Gly Arg Trp Met   Lys Ala Ser 
    18335                 18340                 18345             


Phe Thr   Asn Val Leu Glu Thr   Glu Phe Thr Val Ser   Gly Leu Val 
    18350                 18355                 18360             


Glu Asp   Gln Arg Tyr Glu Phe   Arg Val Ile Ala Arg   Asn Ala Ala 
    18365                 18370                 18375             


Gly Asn   Phe Ser Glu Pro Ser   Asp Ser Ser Gly Ala   Ile Thr Ala 
    18380                 18385                 18390             


Arg Asp   Glu Ile Asp Ala Pro   Asn Ala Ser Leu Asp   Pro Lys Tyr 
    18395                 18400                 18405             


Lys Asp   Val Ile Val Val His   Ala Gly Glu Thr Phe   Val Leu Glu 
    18410                 18415                 18420             


Ala Asp   Ile Arg Gly Lys Pro   Ile Pro Asp Val Val   Trp Ser Lys 
    18425                 18430                 18435             


Asp Gly   Lys Glu Leu Glu Glu   Thr Ala Ala Arg Met   Glu Ile Lys 
    18440                 18445                 18450             


Ser Thr   Ile Gln Lys Thr Thr   Leu Val Val Lys Asp   Cys Ile Arg 
    18455                 18460                 18465             


Thr Asp   Gly Gly Gln Tyr Ile   Leu Lys Leu Ser Asn   Val Gly Gly 
    18470                 18475                 18480             


Thr Lys   Ser Ile Pro Ile Thr   Val Lys Val Leu Asp   Arg Pro Gly 
    18485                 18490                 18495             


Pro Pro   Glu Gly Pro Leu Lys   Val Thr Gly Val Thr   Ala Glu Lys 
    18500                 18505                 18510             


Cys Tyr   Leu Ala Trp Asn Pro   Pro Leu Gln Asp Gly   Gly Ala Asn 
    18515                 18520                 18525             


Ile Ser   His Tyr Ile Ile Glu   Lys Arg Glu Thr Ser   Arg Leu Ser 
    18530                 18535                 18540             


Trp Thr   Gln Val Ser Thr Glu   Val Gln Ala Leu Asn   Tyr Lys Val 
    18545                 18550                 18555             


Thr Lys   Leu Leu Pro Gly Asn   Glu Tyr Ile Phe Arg   Val Met Ala 
    18560                 18565                 18570             


Val Asn   Lys Tyr Gly Ile Gly   Glu Pro Leu Glu Ser   Gly Pro Val 
    18575                 18580                 18585             


Thr Ala   Cys Asn Pro Tyr Lys   Pro Pro Gly Pro Pro   Ser Thr Pro 
    18590                 18595                 18600             


Glu Val   Ser Ala Ile Thr Lys   Asp Ser Met Val Val   Thr Trp Ala 
    18605                 18610                 18615             


Arg Pro   Val Asp Asp Gly Gly   Thr Glu Ile Glu Gly   Tyr Ile Leu 
    18620                 18625                 18630             


Glu Lys   Arg Asp Lys Glu Gly   Val Arg Trp Thr Lys   Cys Asn Lys 
    18635                 18640                 18645             


Lys Thr   Leu Thr Asp Leu Arg   Leu Arg Val Thr Gly   Leu Thr Glu 
    18650                 18655                 18660             


Gly His   Ser Tyr Glu Phe Arg   Val Ala Ala Glu Asn   Ala Ala Gly 
    18665                 18670                 18675             


Val Gly   Glu Pro Ser Glu Pro   Ser Val Phe Tyr Arg   Ala Cys Asp 
    18680                 18685                 18690             


Ala Leu   Tyr Pro Pro Gly Pro   Pro Ser Asn Pro Lys   Val Thr Asp 
    18695                 18700                 18705             


Thr Ser   Arg Ser Ser Val Ser   Leu Ala Trp Ser Lys   Pro Ile Tyr 
    18710                 18715                 18720             


Asp Gly   Gly Ala Pro Val Lys   Gly Tyr Val Val Glu   Val Lys Glu 
    18725                 18730                 18735             


Ala Ala   Ala Asp Glu Trp Thr   Thr Cys Thr Pro Pro   Thr Gly Leu 
    18740                 18745                 18750             


Gln Gly   Lys Gln Phe Thr Val   Thr Lys Leu Lys Glu   Asn Thr Glu 
    18755                 18760                 18765             


Tyr Asn   Phe Arg Ile Cys Ala   Ile Asn Ser Glu Gly   Val Gly Glu 
    18770                 18775                 18780             


Pro Ala   Thr Leu Pro Gly Ser   Val Val Ala Gln Glu   Arg Ile Glu 
    18785                 18790                 18795             


Pro Pro   Glu Ile Glu Leu Asp   Ala Asp Leu Arg Lys   Val Val Val 
    18800                 18805                 18810             


Leu Arg   Ala Ser Ala Thr Leu   Arg Leu Phe Val Thr   Ile Lys Gly 
    18815                 18820                 18825             


Arg Pro   Glu Pro Glu Val Lys   Trp Glu Lys Ala Glu   Gly Ile Leu 
    18830                 18835                 18840             


Thr Asp   Arg Ala Gln Ile Glu   Val Thr Ser Ser Phe   Thr Met Leu 
    18845                 18850                 18855             


Val Ile   Asp Asn Val Thr Arg   Phe Asp Ser Gly Arg   Tyr Asn Leu 
    18860                 18865                 18870             


Thr Leu   Glu Asn Asn Ser Gly   Ser Lys Thr Ala Phe   Val Asn Val 
    18875                 18880                 18885             


Arg Val   Leu Asp Ser Pro Ser   Ala Pro Val Asn Leu   Thr Ile Arg 
    18890                 18895                 18900             


Glu Val   Lys Lys Asp Ser Val   Thr Leu Ser Trp Glu   Pro Pro Leu 
    18905                 18910                 18915             


Ile Asp   Gly Gly Ala Lys Ile   Thr Asn Tyr Ile Val   Glu Lys Arg 
    18920                 18925                 18930             


Glu Thr   Thr Arg Lys Ala Tyr   Ala Thr Ile Thr Asn   Asn Cys Thr 
    18935                 18940                 18945             


Lys Thr   Thr Phe Arg Ile Glu   Asn Leu Gln Glu Gly   Cys Ser Tyr 
    18950                 18955                 18960             


Tyr Phe   Arg Val Leu Ala Ser   Asn Glu Tyr Gly Ile   Gly Leu Pro 
    18965                 18970                 18975             


Ala Glu   Thr Thr Glu Pro Val   Lys Val Ser Glu Pro   Pro Leu Pro 
    18980                 18985                 18990             


Pro Gly   Arg Val Thr Leu Val   Asp Val Thr Arg Asn   Thr Ala Thr 
    18995                 19000                 19005             


Ile Lys   Trp Glu Lys Pro Glu   Ser Asp Gly Gly Ser   Lys Ile Thr 
    19010                 19015                 19020             


Gly Tyr   Val Val Glu Met Gln   Thr Lys Gly Ser Glu   Lys Trp Ser 
    19025                 19030                 19035             


Thr Cys   Thr Gln Val Lys Thr   Leu Glu Ala Thr Ile   Ser Gly Leu 
    19040                 19045                 19050             


Thr Ala   Gly Glu Glu Tyr Val   Phe Arg Val Ala Ala   Val Asn Glu 
    19055                 19060                 19065             


Lys Gly   Arg Ser Asp Pro Arg   Gln Leu Gly Val Pro   Val Ile Ala 
    19070                 19075                 19080             


Arg Asp   Ile Glu Ile Lys Pro   Ser Val Glu Leu Pro   Phe His Thr 
    19085                 19090                 19095             


Phe Asn   Val Lys Ala Arg Glu   Gln Leu Lys Ile Asp   Val Pro Phe 
    19100                 19105                 19110             


Lys Gly   Arg Pro Gln Ala Thr   Val Asn Trp Arg Lys   Asp Gly Gln 
    19115                 19120                 19125             


Thr Leu   Lys Glu Thr Thr Arg   Val Asn Val Ser Ser   Ser Lys Thr 
    19130                 19135                 19140             


Val Thr   Ser Leu Ser Ile Lys   Glu Ala Ser Lys Glu   Asp Val Gly 
    19145                 19150                 19155             


Thr Tyr   Glu Leu Cys Val Ser   Asn Ser Ala Gly Ser   Ile Thr Val 
    19160                 19165                 19170             


Pro Ile   Thr Ile Ile Val Leu   Asp Arg Pro Gly Pro   Pro Gly Pro 
    19175                 19180                 19185             


Ile Arg   Ile Asp Glu Val Ser   Cys Asp Ser Ile Thr   Ile Ser Trp 
    19190                 19195                 19200             


Asn Pro   Pro Glu Tyr Asp Gly   Gly Cys Gln Ile Ser   Asn Tyr Ile 
    19205                 19210                 19215             


Val Glu   Lys Lys Glu Thr Thr   Ser Thr Thr Trp His   Ile Val Ser 
    19220                 19225                 19230             


Gln Ala   Val Ala Arg Thr Ser   Ile Lys Ile Val Arg   Leu Thr Thr 
    19235                 19240                 19245             


Gly Ser   Glu Tyr Gln Phe Arg   Val Cys Ala Glu Asn   Arg Tyr Gly 
    19250                 19255                 19260             


Lys Ser   Ser Tyr Ser Glu Ser   Ser Ala Val Val Ala   Glu Tyr Pro 
    19265                 19270                 19275             


Phe Ser   Pro Pro Gly Pro Pro   Gly Thr Pro Lys Val   Val His Ala 
    19280                 19285                 19290             


Thr Lys   Ser Thr Met Leu Val   Thr Trp Gln Val Pro   Val Asn Asp 
    19295                 19300                 19305             


Gly Gly   Ser Arg Val Ile Gly   Tyr His Leu Glu Tyr   Lys Glu Arg 
    19310                 19315                 19320             


Ser Ser   Ile Leu Trp Ser Lys   Ala Asn Lys Ile Leu   Ile Ala Asp 
    19325                 19330                 19335             


Thr Gln   Met Lys Val Ser Gly   Leu Asp Glu Gly Leu   Met Tyr Glu 
    19340                 19345                 19350             


Tyr Arg   Val Tyr Ala Glu Asn   Ile Ala Gly Ile Gly   Lys Cys Ser 
    19355                 19360                 19365             


Lys Ser   Cys Glu Pro Val Pro   Ala Arg Asp Pro Cys   Asp Pro Pro 
    19370                 19375                 19380             


Gly Gln   Pro Glu Val Thr Asn   Ile Thr Arg Lys Ser   Val Ser Leu 
    19385                 19390                 19395             


Lys Trp   Ser Lys Pro His Tyr   Asp Gly Gly Ala Lys   Ile Thr Gly 
    19400                 19405                 19410             


Tyr Ile   Val Glu Arg Arg Glu   Leu Pro Asp Gly Arg   Trp Leu Lys 
    19415                 19420                 19425             


Cys Asn   Tyr Thr Asn Ile Gln   Glu Thr Tyr Phe Glu   Val Thr Glu 
    19430                 19435                 19440             


Leu Thr   Glu Asp Gln Arg Tyr   Glu Phe Arg Val Phe   Ala Arg Asn 
    19445                 19450                 19455             


Ala Ala   Asp Ser Val Ser Glu   Pro Ser Glu Ser Thr   Gly Pro Ile 
    19460                 19465                 19470             


Ile Val   Lys Asp Asp Val Glu   Pro Pro Arg Val Met   Met Asp Val 
    19475                 19480                 19485             


Lys Phe   Arg Asp Val Ile Val   Val Lys Ala Gly Glu   Val Leu Lys 
    19490                 19495                 19500             


Ile Asn   Ala Asp Ile Ala Gly   Arg Pro Leu Pro Val   Ile Ser Trp 
    19505                 19510                 19515             


Ala Lys   Asp Gly Ile Glu Ile   Glu Glu Arg Ala Arg   Thr Glu Ile 
    19520                 19525                 19530             


Ile Ser   Thr Asp Asn His Thr   Leu Leu Thr Val Lys   Asp Cys Ile 
    19535                 19540                 19545             


Arg Arg   Asp Thr Gly Gln Tyr   Val Leu Thr Leu Lys   Asn Val Ala 
    19550                 19555                 19560             


Gly Thr   Arg Ser Val Ala Val   Asn Cys Lys Val Leu   Asp Lys Pro 
    19565                 19570                 19575             


Gly Pro   Pro Ala Gly Pro Leu   Glu Ile Asn Gly Leu   Thr Ala Glu 
    19580                 19585                 19590             


Lys Cys   Ser Leu Ser Trp Gly   Arg Pro Gln Glu Asp   Gly Gly Ala 
    19595                 19600                 19605             


Asp Ile   Asp Tyr Tyr Ile Val   Glu Lys Arg Glu Thr   Ser His Leu 
    19610                 19615                 19620             


Ala Trp   Thr Ile Cys Glu Gly   Glu Leu Gln Met Thr   Ser Cys Lys 
    19625                 19630                 19635             


Val Thr   Lys Leu Leu Lys Gly   Asn Glu Tyr Ile Phe   Arg Val Thr 
    19640                 19645                 19650             


Gly Val   Asn Lys Tyr Gly Val   Gly Glu Pro Leu Glu   Ser Val Ala 
    19655                 19660                 19665             


Ile Lys   Ala Leu Asp Pro Phe   Thr Val Pro Ser Pro   Pro Thr Ser 
    19670                 19675                 19680             


Leu Glu   Ile Thr Ser Val Thr   Lys Glu Ser Met Thr   Leu Cys Trp 
    19685                 19690                 19695             


Ser Arg   Pro Glu Ser Asp Gly   Gly Ser Glu Ile Ser   Gly Tyr Ile 
    19700                 19705                 19710             


Ile Glu   Arg Arg Glu Lys Asn   Ser Leu Arg Trp Val   Arg Val Asn 
    19715                 19720                 19725             


Lys Lys   Pro Val Tyr Asp Leu   Arg Val Lys Ser Thr   Gly Leu Arg 
    19730                 19735                 19740             


Glu Gly   Cys Glu Tyr Glu Tyr   Arg Val Tyr Ala Glu   Asn Ala Ala 
    19745                 19750                 19755             


Gly Leu   Ser Leu Pro Ser Glu   Thr Ser Pro Leu Ile   Arg Ala Glu 
    19760                 19765                 19770             


Asp Pro   Val Phe Leu Pro Ser   Pro Pro Ser Lys Pro   Lys Ile Val 
    19775                 19780                 19785             


Asp Ser   Gly Lys Thr Thr Ile   Thr Ile Ala Trp Val   Lys Pro Leu 
    19790                 19795                 19800             


Phe Asp   Gly Gly Ala Pro Ile   Thr Gly Tyr Thr Val   Glu Tyr Lys 
    19805                 19810                 19815             


Lys Ser   Asp Asp Thr Asp Trp   Lys Thr Ser Ile Gln   Ser Leu Arg 
    19820                 19825                 19830             


Gly Thr   Glu Tyr Thr Ile Ser   Gly Leu Thr Thr Gly   Ala Glu Tyr 
    19835                 19840                 19845             


Val Phe   Arg Val Lys Ser Val   Asn Lys Val Gly Ala   Ser Asp Pro 
    19850                 19855                 19860             


Ser Asp   Ser Ser Asp Pro Gln   Ile Ala Lys Glu Arg   Glu Glu Glu 
    19865                 19870                 19875             


Pro Leu   Phe Asp Ile Asp Ser   Glu Met Arg Lys Thr   Leu Ile Val 
    19880                 19885                 19890             


Lys Ala   Gly Ala Ser Phe Thr   Met Thr Val Pro Phe   Arg Gly Arg 
    19895                 19900                 19905             


Pro Val   Pro Asn Val Leu Trp   Ser Lys Pro Asp Thr   Asp Leu Arg 
    19910                 19915                 19920             


Thr Arg   Ala Tyr Val Asp Thr   Thr Asp Ser Arg Thr   Ser Leu Thr 
    19925                 19930                 19935             


Ile Glu   Asn Ala Asn Arg Asn   Asp Ser Gly Lys Tyr   Thr Leu Thr 
    19940                 19945                 19950             


Ile Gln   Asn Val Leu Ser Ala   Ala Ser Leu Thr Leu   Val Val Lys 
    19955                 19960                 19965             


Val Leu   Asp Thr Pro Gly Pro   Pro Thr Asn Ile Thr   Val Gln Asp 
    19970                 19975                 19980             


Val Thr   Lys Glu Ser Ala Val   Leu Ser Trp Asp Val   Pro Glu Asn 
    19985                 19990                 19995             


Asp Gly   Gly Ala Pro Val Lys   Asn Tyr His Ile Glu   Lys Arg Glu 
    20000                 20005                 20010             


Ala Ser   Lys Lys Ala Trp Val   Ser Val Thr Asn Asn   Cys Asn Arg 
    20015                 20020                 20025             


Leu Ser   Tyr Lys Val Thr Asn   Leu Gln Glu Gly Ala   Ile Tyr Tyr 
    20030                 20035                 20040             


Phe Arg   Val Ser Gly Glu Asn   Glu Phe Gly Val Gly   Ile Pro Ala 
    20045                 20050                 20055             


Glu Thr   Lys Glu Gly Val Lys   Ile Thr Glu Lys Pro   Ser Pro Pro 
    20060                 20065                 20070             


Glu Lys   Leu Gly Val Thr Ser   Ile Ser Lys Asp Ser   Val Ser Leu 
    20075                 20080                 20085             


Thr Trp   Leu Lys Pro Glu His   Asp Gly Gly Ser Arg   Ile Val His 
    20090                 20095                 20100             


Tyr Val   Val Glu Ala Leu Glu   Lys Gly Gln Lys Asn   Trp Val Lys 
    20105                 20110                 20115             


Cys Ala   Val Ala Lys Ser Thr   His His Val Val Ser   Gly Leu Arg 
    20120                 20125                 20130             


Glu Asn   Ser Glu Tyr Phe Phe   Arg Val Phe Ala Glu   Asn Gln Ala 
    20135                 20140                 20145             


Gly Leu   Ser Asp Pro Arg Glu   Leu Leu Leu Pro Val   Leu Ile Lys 
    20150                 20155                 20160             


Glu Gln   Leu Glu Pro Pro Glu   Ile Asp Met Lys Asn   Phe Pro Ser 
    20165                 20170                 20175             


His Thr   Val Tyr Val Arg Ala   Gly Ser Asn Leu Lys   Val Asp Ile 
    20180                 20185                 20190             


Pro Ile   Ser Gly Lys Pro Leu   Pro Lys Val Thr Leu   Ser Arg Asp 
    20195                 20200                 20205             


Gly Val   Pro Leu Lys Ala Thr   Met Arg Phe Asn Thr   Glu Ile Thr 
    20210                 20215                 20220             


Ala Glu   Asn Leu Thr Ile Asn   Leu Lys Glu Ser Val   Thr Ala Asp 
    20225                 20230                 20235             


Ala Gly   Arg Tyr Glu Ile Thr   Ala Ala Asn Ser Ser   Gly Thr Thr 
    20240                 20245                 20250             


Lys Ala   Phe Ile Asn Ile Val   Val Leu Asp Arg Pro   Gly Pro Pro 
    20255                 20260                 20265             


Thr Gly   Pro Val Val Ile Ser   Asp Ile Thr Glu Glu   Ser Val Thr 
    20270                 20275                 20280             


Leu Lys   Trp Glu Pro Pro Lys   Tyr Asp Gly Gly Ser   Gln Val Thr 
    20285                 20290                 20295             


Asn Tyr   Ile Leu Leu Lys Arg   Glu Thr Ser Thr Ala   Val Trp Thr 
    20300                 20305                 20310             


Glu Val   Ser Ala Thr Val Ala   Arg Thr Met Met Lys   Val Met Lys 
    20315                 20320                 20325             


Leu Thr   Thr Gly Glu Glu Tyr   Gln Phe Arg Ile Lys   Ala Glu Asn 
    20330                 20335                 20340             


Arg Phe   Gly Ile Ser Asp His   Ile Asp Ser Ala Cys   Val Thr Val 
    20345                 20350                 20355             


Lys Leu   Pro Tyr Thr Thr Pro   Gly Pro Pro Ser Thr   Pro Trp Val 
    20360                 20365                 20370             


Thr Asn   Val Thr Arg Glu Ser   Ile Thr Val Gly Trp   His Glu Pro 
    20375                 20380                 20385             


Val Ser   Asn Gly Gly Ser Ala   Val Val Gly Tyr His   Leu Glu Met 
    20390                 20395                 20400             


Lys Asp   Arg Asn Ser Ile Leu   Trp Gln Lys Ala Asn   Lys Leu Val 
    20405                 20410                 20415             


Ile Arg   Thr Thr His Phe Lys   Val Thr Thr Ile Ser   Ala Gly Leu 
    20420                 20425                 20430             


Ile Tyr   Glu Phe Arg Val Tyr   Ala Glu Asn Ala Ala   Gly Val Gly 
    20435                 20440                 20445             


Lys Pro   Ser His Pro Ser Glu   Pro Val Leu Ala Ile   Asp Ala Cys 
    20450                 20455                 20460             


Glu Pro   Pro Arg Asn Val Arg   Ile Thr Asp Ile Ser   Lys Asn Ser 
    20465                 20470                 20475             


Val Ser   Leu Ser Trp Gln Gln   Pro Ala Phe Asp Gly   Gly Ser Lys 
    20480                 20485                 20490             


Ile Thr   Gly Tyr Ile Val Glu   Arg Arg Asp Leu Pro   Asp Gly Arg 
    20495                 20500                 20505             


Trp Thr   Lys Ala Ser Phe Thr   Asn Val Thr Glu Thr   Gln Phe Ile 
    20510                 20515                 20520             


Ile Ser   Gly Leu Thr Gln Asn   Ser Gln Tyr Glu Phe   Arg Val Phe 
    20525                 20530                 20535             


Ala Arg   Asn Ala Val Gly Ser   Ile Ser Asn Pro Ser   Glu Val Val 
    20540                 20545                 20550             


Gly Pro   Ile Thr Cys Ile Asp   Ser Tyr Gly Gly Pro   Val Ile Asp 
    20555                 20560                 20565             


Leu Pro   Leu Glu Tyr Thr Glu   Val Val Lys Tyr Arg   Ala Gly Thr 
    20570                 20575                 20580             


Ser Val   Lys Leu Arg Ala Gly   Ile Ser Gly Lys Pro   Ala Pro Thr 
    20585                 20590                 20595             


Ile Glu   Trp Tyr Lys Asp Asp   Lys Glu Leu Gln Thr   Asn Ala Leu 
    20600                 20605                 20610             


Val Cys   Val Glu Asn Thr Thr   Asp Leu Ala Ser Ile   Leu Ile Lys 
    20615                 20620                 20625             


Asp Ala   Asp Arg Leu Asn Ser   Gly Cys Tyr Glu Leu   Lys Leu Arg 
    20630                 20635                 20640             


Asn Ala   Met Gly Ser Ala Ser   Ala Thr Ile Arg Val   Gln Ile Leu 
    20645                 20650                 20655             


Asp Lys   Pro Gly Pro Pro Gly   Gly Pro Ile Glu Phe   Lys Thr Val 
    20660                 20665                 20670             


Thr Ala   Glu Lys Ile Thr Leu   Leu Trp Arg Pro Pro   Ala Asp Asp 
    20675                 20680                 20685             


Gly Gly   Ala Lys Ile Thr His   Tyr Ile Val Glu Lys   Arg Glu Thr 
    20690                 20695                 20700             


Ser Arg   Val Val Trp Ser Met   Val Ser Glu His Leu   Glu Glu Cys 
    20705                 20710                 20715             


Ile Ile   Thr Thr Thr Lys Ile   Ile Lys Gly Asn Glu   Tyr Ile Phe 
    20720                 20725                 20730             


Arg Val   Arg Ala Val Asn Lys   Tyr Gly Ile Gly Glu   Pro Leu Glu 
    20735                 20740                 20745             


Ser Asp   Ser Val Val Ala Lys   Asn Ala Phe Val Thr   Pro Gly Pro 
    20750                 20755                 20760             


Pro Gly   Ile Pro Glu Val Thr   Lys Ile Thr Lys Asn   Ser Met Thr 
    20765                 20770                 20775             


Val Val   Trp Ser Arg Pro Ile   Ala Asp Gly Gly Ser   Asp Ile Ser 
    20780                 20785                 20790             


Gly Tyr   Phe Leu Glu Lys Arg   Asp Lys Lys Ser Leu   Gly Trp Phe 
    20795                 20800                 20805             


Lys Val   Leu Lys Glu Thr Ile   Arg Asp Thr Arg Gln   Lys Val Thr 
    20810                 20815                 20820             


Gly Leu   Thr Glu Asn Ser Asp   Tyr Gln Tyr Arg Val   Cys Ala Val 
    20825                 20830                 20835             


Asn Ala   Ala Gly Gln Gly Pro   Phe Ser Glu Pro Ser   Glu Phe Tyr 
    20840                 20845                 20850             


Lys Ala   Ala Asp Pro Ile Asp   Pro Pro Gly Pro Pro   Ala Lys Ile 
    20855                 20860                 20865             


Arg Ile   Ala Asp Ser Thr Lys   Ser Ser Ile Thr Leu   Gly Trp Ser 
    20870                 20875                 20880             


Lys Pro   Val Tyr Asp Gly Gly   Ser Ala Val Thr Gly   Tyr Val Val 
    20885                 20890                 20895             


Glu Ile   Arg Gln Gly Glu Glu   Glu Glu Trp Thr Thr   Val Ser Thr 
    20900                 20905                 20910             


Lys Gly   Glu Val Arg Thr Thr   Glu Tyr Val Val Ser   Asn Leu Lys 
    20915                 20920                 20925             


Pro Gly   Val Asn Tyr Tyr Phe   Arg Val Ser Ala Val   Asn Cys Ala 
    20930                 20935                 20940             


Gly Gln   Gly Glu Pro Ile Glu   Met Asn Glu Pro Val   Gln Ala Lys 
    20945                 20950                 20955             


Asp Ile   Leu Glu Ala Pro Glu   Ile Asp Leu Asp Val   Ala Leu Arg 
    20960                 20965                 20970             


Thr Ser   Val Ile Ala Lys Ala   Gly Glu Asp Val Gln   Val Leu Ile 
    20975                 20980                 20985             


Pro Phe   Lys Gly Arg Pro Pro   Pro Thr Val Thr Trp   Arg Lys Asp 
    20990                 20995                 21000             


Glu Lys   Asn Leu Gly Ser Asp   Ala Arg Tyr Ser Ile   Glu Asn Thr 
    21005                 21010                 21015             


Asp Ser   Ser Ser Leu Leu Thr   Ile Pro Gln Val Thr   Arg Asn Asp 
    21020                 21025                 21030             


Thr Gly   Lys Tyr Ile Leu Thr   Ile Glu Asn Gly Val   Gly Glu Pro 
    21035                 21040                 21045             


Lys Ser   Ser Thr Val Ser Val   Lys Val Leu Asp Thr   Pro Ala Ala 
    21050                 21055                 21060             


Cys Gln   Lys Leu Gln Val Lys   His Val Ser Arg Gly   Thr Val Thr 
    21065                 21070                 21075             


Leu Leu   Trp Asp Pro Pro Leu   Ile Asp Gly Gly Ser   Pro Ile Ile 
    21080                 21085                 21090             


Asn Tyr   Val Ile Glu Lys Arg   Asp Ala Thr Lys Arg   Thr Trp Ser 
    21095                 21100                 21105             


Val Val   Ser His Lys Cys Ser   Ser Thr Ser Phe Lys   Leu Ile Asp 
    21110                 21115                 21120             


Leu Ser   Glu Lys Thr Pro Phe   Phe Phe Arg Val Leu   Ala Glu Asn 
    21125                 21130                 21135             


Glu Ile   Gly Ile Gly Glu Pro   Cys Glu Thr Thr Glu   Pro Val Lys 
    21140                 21145                 21150             


Ala Ala   Glu Val Pro Ala Pro   Ile Arg Asp Leu Ser   Met Lys Asp 
    21155                 21160                 21165             


Ser Thr   Lys Thr Ser Val Ile   Leu Ser Trp Thr Lys   Pro Asp Phe 
    21170                 21175                 21180             


Asp Gly   Gly Ser Val Ile Thr   Glu Tyr Val Val Glu   Arg Lys Gly 
    21185                 21190                 21195             


Lys Gly   Glu Gln Thr Trp Ser   His Ala Gly Ile Ser   Lys Thr Cys 
    21200                 21205                 21210             


Glu Ile   Glu Val Ser Gln Leu   Lys Glu Gln Ser Val   Leu Glu Phe 
    21215                 21220                 21225             


Arg Val   Phe Ala Lys Asn Glu   Lys Gly Leu Ser Asp   Pro Val Thr 
    21230                 21235                 21240             


Ile Gly   Pro Ile Thr Val Lys   Glu Leu Ile Ile Thr   Pro Glu Val 
    21245                 21250                 21255             


Asp Leu   Ser Asp Ile Pro Gly   Ala Gln Val Thr Val   Arg Ile Gly 
    21260                 21265                 21270             


His Asn   Val His Leu Glu Leu   Pro Tyr Lys Gly Lys   Pro Lys Pro 
    21275                 21280                 21285             


Ser Ile   Ser Trp Leu Lys Asp   Gly Leu Pro Leu Lys   Glu Ser Glu 
    21290                 21295                 21300             


Phe Val   Arg Phe Ser Lys Thr   Glu Asn Lys Ile Thr   Leu Ser Ile 
    21305                 21310                 21315             


Lys Asn   Ala Lys Lys Glu His   Gly Gly Lys Tyr Thr   Val Ile Leu 
    21320                 21325                 21330             


Asp Asn   Ala Val Cys Arg Ile   Ala Val Pro Ile Thr   Val Ile Thr 
    21335                 21340                 21345             


Leu Gly   Pro Pro Ser Lys Pro   Lys Gly Pro Ile Arg   Phe Asp Glu 
    21350                 21355                 21360             


Ile Lys   Ala Asp Ser Val Ile   Leu Ser Trp Asp Val   Pro Glu Asp 
    21365                 21370                 21375             


Asn Gly   Gly Gly Glu Ile Thr   Cys Tyr Ser Ile Glu   Lys Arg Glu 
    21380                 21385                 21390             


Thr Ser   Gln Thr Asn Trp Arg   Met Val Cys Ser Ser   Val Ala Arg 
    21395                 21400                 21405             


Thr Thr   Phe Lys Val Pro Asn   Leu Val Lys Asp Ala   Glu Tyr Gln 
    21410                 21415                 21420             


Phe Arg   Val Arg Ala Glu Asn   Arg Tyr Gly Val Ser   Gln Pro Leu 
    21425                 21430                 21435             


Val Ser   Ser Ile Ile Val Ala   Lys His Gln Phe Arg   Ile Pro Gly 
    21440                 21445                 21450             


Pro Pro   Gly Lys Pro Val Ile   Tyr Asn Val Thr Ser   Asp Gly Met 
    21455                 21460                 21465             


Ser Leu   Thr Trp Asp Ala Pro   Val Tyr Asp Gly Gly   Ser Glu Val 
    21470                 21475                 21480             


Thr Gly   Phe His Val Glu Lys   Lys Glu Arg Asn Ser   Ile Leu Trp 
    21485                 21490                 21495             


Gln Lys   Val Asn Thr Ser Pro   Ile Ser Gly Arg Glu   Tyr Arg Ala 
    21500                 21505                 21510             


Thr Gly   Leu Val Glu Gly Leu   Asp Tyr Gln Phe Arg   Val Tyr Ala 
    21515                 21520                 21525             


Glu Asn   Ser Ala Gly Leu Ser   Ser Pro Ser Asp Pro   Ser Lys Phe 
    21530                 21535                 21540             


Thr Leu   Ala Val Ser Pro Val   Asp Pro Pro Gly Thr   Pro Asp Tyr 
    21545                 21550                 21555             


Ile Asp   Val Thr Arg Glu Thr   Ile Thr Leu Lys Trp   Asn Pro Pro 
    21560                 21565                 21570             


Leu Arg   Asp Gly Gly Ser Lys   Ile Val Gly Tyr Ser   Ile Glu Lys 
    21575                 21580                 21585             


Arg Gln   Gly Asn Glu Arg Trp   Val Arg Cys Asn Phe   Thr Asp Val 
    21590                 21595                 21600             


Ser Glu   Cys Gln Tyr Thr Val   Thr Gly Leu Ser Pro   Gly Asp Arg 
    21605                 21610                 21615             


Tyr Glu   Phe Arg Ile Ile Ala   Arg Asn Ala Val Gly   Thr Ile Ser 
    21620                 21625                 21630             


Pro Pro   Ser Gln Ser Ser Gly   Ile Ile Met Thr Arg   Asp Glu Asn 
    21635                 21640                 21645             


Val Pro   Pro Ile Val Glu Phe   Gly Pro Glu Tyr Phe   Asp Gly Leu 
    21650                 21655                 21660             


Ile Ile   Lys Ser Gly Glu Ser   Leu Arg Ile Lys Ala   Leu Val Gln 
    21665                 21670                 21675             


Gly Arg   Pro Val Pro Arg Val   Thr Trp Phe Lys Asp   Gly Val Glu 
    21680                 21685                 21690             


Ile Glu   Lys Arg Met Asn Met   Glu Ile Thr Asp Val   Leu Gly Ser 
    21695                 21700                 21705             


Thr Ser   Leu Phe Val Arg Asp   Ala Thr Arg Asp His   Arg Gly Val 
    21710                 21715                 21720             


Tyr Thr   Val Glu Ala Lys Asn   Ala Ser Gly Ser Ala   Lys Ala Glu 
    21725                 21730                 21735             


Ile Lys   Val Lys Val Gln Asp   Thr Pro Gly Lys Val   Val Gly Pro 
    21740                 21745                 21750             


Ile Arg   Phe Thr Asn Ile Thr   Gly Glu Lys Met Thr   Leu Trp Trp 
    21755                 21760                 21765             


Asp Ala   Pro Leu Asn Asp Gly   Cys Ala Pro Ile Thr   His Tyr Ile 
    21770                 21775                 21780             


Ile Glu   Lys Arg Glu Thr Ser   Arg Leu Ala Trp Ala   Leu Ile Glu 
    21785                 21790                 21795             


Asp Lys   Cys Glu Ala Gln Ser   Tyr Thr Ala Ile Lys   Leu Ile Asn 
    21800                 21805                 21810             


Gly Asn   Glu Tyr Gln Phe Arg   Val Ser Ala Val Asn   Lys Phe Gly 
    21815                 21820                 21825             


Val Gly   Arg Pro Leu Asp Ser   Asp Pro Val Val Ala   Gln Ile Gln 
    21830                 21835                 21840             


Tyr Thr   Val Pro Asp Ala Pro   Gly Ile Pro Glu Pro   Ser Asn Ile 
    21845                 21850                 21855             


Thr Gly   Asn Ser Ile Thr Leu   Thr Trp Ala Arg Pro   Glu Ser Asp 
    21860                 21865                 21870             


Gly Gly   Ser Glu Ile Gln Gln   Tyr Ile Leu Glu Arg   Arg Glu Lys 
    21875                 21880                 21885             


Lys Ser   Thr Arg Trp Val Lys   Val Ile Ser Lys Arg   Pro Ile Ser 
    21890                 21895                 21900             


Glu Thr   Arg Phe Lys Val Thr   Gly Leu Thr Glu Gly   Asn Glu Tyr 
    21905                 21910                 21915             


Glu Phe   His Val Met Ala Glu   Asn Ala Ala Gly Val   Gly Pro Ala 
    21920                 21925                 21930             


Ser Gly   Ile Ser Arg Leu Ile   Lys Cys Arg Glu Pro   Val Asn Pro 
    21935                 21940                 21945             


Pro Gly   Pro Pro Thr Val Val   Lys Val Thr Asp Thr   Ser Lys Thr 
    21950                 21955                 21960             


Thr Val   Ser Leu Glu Trp Ser   Lys Pro Val Phe Asp   Gly Gly Met 
    21965                 21970                 21975             


Glu Ile   Ile Gly Tyr Ile Ile   Glu Met Cys Lys Ala   Asp Leu Gly 
    21980                 21985                 21990             


Asp Trp   His Lys Val Asn Ala   Glu Ala Cys Val Lys   Thr Arg Tyr 
    21995                 22000                 22005             


Thr Val   Thr Asp Leu Gln Ala   Gly Glu Glu Tyr Lys   Phe Arg Val 
    22010                 22015                 22020             


Ser Ala   Ile Asn Gly Ala Gly   Lys Gly Asp Ser Cys   Glu Val Thr 
    22025                 22030                 22035             


Gly Thr   Ile Lys Ala Val Asp   Arg Leu Thr Ala Pro   Glu Leu Asp 
    22040                 22045                 22050             


Ile Asp   Ala Asn Phe Lys Gln   Thr His Val Val Arg   Ala Gly Ala 
    22055                 22060                 22065             


Ser Ile   Arg Leu Phe Ile Ala   Tyr Gln Gly Arg Pro   Thr Pro Thr 
    22070                 22075                 22080             


Ala Val   Trp Ser Lys Pro Asp   Ser Asn Leu Ser Leu   Arg Ala Asp 
    22085                 22090                 22095             


Ile His   Thr Thr Asp Ser Phe   Ser Thr Leu Thr Val   Glu Asn Cys 
    22100                 22105                 22110             


Asn Arg   Asn Asp Ala Gly Lys   Tyr Thr Leu Thr Val   Glu Asn Asn 
    22115                 22120                 22125             


Ser Gly   Ser Lys Ser Ile Thr   Phe Thr Val Lys Val   Leu Asp Thr 
    22130                 22135                 22140             


Pro Gly   Pro Pro Gly Pro Ile   Thr Phe Lys Asp Val   Thr Arg Gly 
    22145                 22150                 22155             


Ser Ala   Thr Leu Met Trp Asp   Ala Pro Leu Leu Asp   Gly Gly Ala 
    22160                 22165                 22170             


Arg Ile   His His Tyr Val Val   Glu Lys Arg Glu Ala   Ser Arg Arg 
    22175                 22180                 22185             


Ser Trp   Gln Val Ile Ser Glu   Lys Cys Thr Arg Gln   Ile Phe Lys 
    22190                 22195                 22200             


Val Asn   Asp Leu Ala Glu Gly   Val Pro Tyr Tyr Phe   Arg Val Ser 
    22205                 22210                 22215             


Ala Val   Asn Glu Tyr Gly Val   Gly Glu Pro Tyr Glu   Met Pro Glu 
    22220                 22225                 22230             


Pro Ile   Val Ala Thr Glu Gln   Pro Ala Pro Pro Arg   Arg Leu Asp 
    22235                 22240                 22245             


Val Val   Asp Thr Ser Lys Ser   Ser Ala Val Leu Ala   Trp Leu Lys 
    22250                 22255                 22260             


Pro Asp   His Asp Gly Gly Ser   Arg Ile Thr Gly Tyr   Leu Leu Glu 
    22265                 22270                 22275             


Met Arg   Gln Lys Gly Ser Asp   Phe Trp Val Glu Ala   Gly His Thr 
    22280                 22285                 22290             


Lys Gln   Leu Thr Phe Thr Val   Glu Arg Leu Val Glu   Lys Thr Glu 
    22295                 22300                 22305             


Tyr Glu   Phe Arg Val Lys Ala   Lys Asn Asp Ala Gly   Tyr Ser Glu 
    22310                 22315                 22320             


Pro Arg   Glu Ala Phe Ser Ser   Val Ile Ile Lys Glu   Pro Gln Ile 
    22325                 22330                 22335             


Glu Pro   Thr Ala Asp Leu Thr   Gly Ile Thr Asn Gln   Leu Ile Thr 
    22340                 22345                 22350             


Cys Lys   Ala Gly Ser Pro Phe   Thr Ile Asp Val Pro   Ile Ser Gly 
    22355                 22360                 22365             


Arg Pro   Ala Pro Lys Val Thr   Trp Lys Leu Glu Glu   Met Arg Leu 
    22370                 22375                 22380             


Lys Glu   Thr Asp Arg Val Ser   Ile Thr Thr Thr Lys   Asp Arg Thr 
    22385                 22390                 22395             


Thr Leu   Thr Val Lys Asp Ser   Met Arg Gly Asp Ser   Gly Arg Tyr 
    22400                 22405                 22410             


Phe Leu   Thr Leu Glu Asn Thr   Ala Gly Val Lys Thr   Phe Ser Val 
    22415                 22420                 22425             


Thr Val   Val Val Ile Gly Arg   Pro Gly Pro Val Thr   Gly Pro Ile 
    22430                 22435                 22440             


Glu Val   Ser Ser Val Ser Ala   Glu Ser Cys Val Leu   Ser Trp Gly 
    22445                 22450                 22455             


Glu Pro   Lys Asp Gly Gly Gly   Thr Glu Ile Thr Asn   Tyr Ile Val 
    22460                 22465                 22470             


Glu Lys   Arg Glu Ser Gly Thr   Thr Ala Trp Gln Leu   Val Asn Ser 
    22475                 22480                 22485             


Ser Val   Lys Arg Thr Gln Ile   Lys Val Thr His Leu   Thr Lys Tyr 
    22490                 22495                 22500             


Met Glu   Tyr Ser Phe Arg Val   Ser Ser Glu Asn Arg   Phe Gly Val 
    22505                 22510                 22515             


Ser Lys   Pro Leu Glu Ser Ala   Pro Ile Ile Ala Glu   His Pro Phe 
    22520                 22525                 22530             


Val Pro   Pro Ser Ala Pro Thr   Arg Pro Glu Val Tyr   His Val Ser 
    22535                 22540                 22545             


Ala Asn   Ala Met Ser Ile Arg   Trp Glu Glu Pro Tyr   His Asp Gly 
    22550                 22555                 22560             


Gly Ser   Lys Ile Ile Gly Tyr   Trp Val Glu Lys Lys   Glu Arg Asn 
    22565                 22570                 22575             


Thr Ile   Leu Trp Val Lys Glu   Asn Lys Val Pro Cys   Leu Glu Cys 
    22580                 22585                 22590             


Asn Tyr   Lys Val Thr Gly Leu   Val Glu Gly Leu Glu   Tyr Gln Phe 
    22595                 22600                 22605             


Arg Thr   Tyr Ala Leu Asn Ala   Ala Gly Val Ser Lys   Ala Ser Glu 
    22610                 22615                 22620             


Ala Ser   Arg Pro Ile Met Ala   Gln Asn Pro Val Asp   Ala Pro Gly 
    22625                 22630                 22635             


Arg Pro   Glu Val Thr Asp Val   Thr Arg Ser Thr Val   Ser Leu Ile 
    22640                 22645                 22650             


Trp Ser   Ala Pro Ala Tyr Asp   Gly Gly Ser Lys Val   Val Gly Tyr 
    22655                 22660                 22665             


Ile Ile   Glu Arg Lys Pro Val   Ser Glu Val Gly Asp   Gly Arg Trp 
    22670                 22675                 22680             


Leu Lys   Cys Asn Tyr Thr Ile   Val Ser Asp Asn Phe   Phe Thr Val 
    22685                 22690                 22695             


Thr Ala   Leu Ser Glu Gly Asp   Thr Tyr Glu Phe Arg   Val Leu Ala 
    22700                 22705                 22710             


Lys Asn   Ala Ala Gly Val Ile   Ser Lys Gly Ser Glu   Ser Thr Gly 
    22715                 22720                 22725             


Pro Val   Thr Cys Arg Asp Glu   Tyr Ala Pro Pro Lys   Ala Glu Leu 
    22730                 22735                 22740             


Asp Ala   Arg Leu His Gly Asp   Leu Val Thr Ile Arg   Ala Gly Ser 
    22745                 22750                 22755             


Asp Leu   Val Leu Asp Ala Ala   Val Gly Gly Lys Pro   Glu Pro Lys 
    22760                 22765                 22770             


Ile Ile   Trp Thr Lys Gly Asp   Lys Glu Leu Asp Leu   Cys Glu Lys 
    22775                 22780                 22785             


Val Ser   Leu Gln Tyr Thr Gly   Lys Arg Ala Thr Ala   Val Ile Lys 
    22790                 22795                 22800             


Phe Cys   Asp Arg Ser Asp Ser   Gly Lys Tyr Thr Leu   Thr Val Lys 
    22805                 22810                 22815             


Asn Ala   Ser Gly Thr Lys Ala   Val Ser Val Met Val   Lys Val Leu 
    22820                 22825                 22830             


Asp Ser   Pro Gly Pro Cys Gly   Lys Leu Thr Val Ser   Arg Val Thr 
    22835                 22840                 22845             


Gln Glu   Lys Cys Thr Leu Ala   Trp Ser Leu Pro Gln   Glu Asp Gly 
    22850                 22855                 22860             


Gly Ala   Glu Ile Thr His Tyr   Ile Val Glu Arg Arg   Glu Thr Ser 
    22865                 22870                 22875             


Arg Leu   Asn Trp Val Ile Val   Glu Gly Glu Cys Pro   Thr Leu Ser 
    22880                 22885                 22890             


Tyr Val   Val Thr Arg Leu Ile   Lys Asn Asn Glu Tyr   Ile Phe Arg 
    22895                 22900                 22905             


Val Arg   Ala Val Asn Lys Tyr   Gly Pro Gly Val Pro   Val Glu Ser 
    22910                 22915                 22920             


Glu Pro   Ile Val Ala Arg Asn   Ser Phe Thr Ile Pro   Ser Pro Pro 
    22925                 22930                 22935             


Gly Ile   Pro Glu Glu Val Gly   Thr Gly Lys Glu His   Ile Ile Ile 
    22940                 22945                 22950             


Gln Trp   Thr Lys Pro Glu Ser   Asp Gly Gly Asn Glu   Ile Ser Asn 
    22955                 22960                 22965             


Tyr Leu   Val Asp Lys Arg Glu   Lys Lys Ser Leu Arg   Trp Thr Arg 
    22970                 22975                 22980             


Val Asn   Lys Asp Tyr Val Val   Tyr Asp Thr Arg Leu   Lys Val Thr 
    22985                 22990                 22995             


Ser Leu   Met Glu Gly Cys Asp   Tyr Gln Phe Arg Val   Thr Ala Val 
    23000                 23005                 23010             


Asn Ala   Ala Gly Asn Ser Glu   Pro Ser Glu Ala Ser   Asn Phe Ile 
    23015                 23020                 23025             


Ser Cys   Arg Glu Pro Ser Tyr   Thr Pro Gly Pro Pro   Ser Ala Pro 
    23030                 23035                 23040             


Arg Val   Val Asp Thr Thr Lys   His Ser Ile Ser Leu   Ala Trp Thr 
    23045                 23050                 23055             


Lys Pro   Met Tyr Asp Gly Gly   Thr Asp Ile Val Gly   Tyr Val Leu 
    23060                 23065                 23070             


Glu Met   Gln Glu Lys Asp Thr   Asp Gln Trp Tyr Arg   Val His Thr 
    23075                 23080                 23085             


Asn Ala   Thr Ile Arg Asn Thr   Glu Phe Thr Val Pro   Asp Leu Lys 
    23090                 23095                 23100             


Met Gly   Gln Lys Tyr Ser Phe   Arg Val Ala Ala Val   Asn Val Lys 
    23105                 23110                 23115             


Gly Met   Ser Glu Tyr Ser Glu   Ser Ile Ala Glu Ile   Glu Pro Val 
    23120                 23125                 23130             


Glu Arg   Ile Glu Ile Pro Asp   Leu Glu Leu Ala Asp   Asp Leu Lys 
    23135                 23140                 23145             


Lys Thr   Val Thr Ile Arg Ala   Gly Ala Ser Leu Arg   Leu Met Val 
    23150                 23155                 23160             


Ser Val   Ser Gly Arg Pro Pro   Pro Val Ile Thr Trp   Ser Lys Gln 
    23165                 23170                 23175             


Gly Ile   Asp Leu Ala Ser Arg   Ala Ile Ile Asp Thr   Thr Glu Ser 
    23180                 23185                 23190             


Tyr Ser   Leu Leu Ile Val Asp   Lys Val Asn Arg Tyr   Asp Ala Gly 
    23195                 23200                 23205             


Lys Tyr   Thr Ile Glu Ala Glu   Asn Gln Ser Gly Lys   Lys Ser Ala 
    23210                 23215                 23220             


Thr Val   Leu Val Lys Val Tyr   Asp Thr Pro Gly Pro   Cys Pro Ser 
    23225                 23230                 23235             


Val Lys   Val Lys Glu Val Ser   Arg Asp Ser Val Thr   Ile Thr Trp 
    23240                 23245                 23250             


Glu Ile   Pro Thr Ile Asp Gly   Gly Ala Pro Val Asn   Asn Tyr Ile 
    23255                 23260                 23265             


Val Glu   Lys Arg Glu Ala Ala   Met Arg Ala Phe Lys   Thr Val Thr 
    23270                 23275                 23280             


Thr Lys   Cys Ser Lys Thr Leu   Tyr Arg Ile Ser Gly   Leu Val Glu 
    23285                 23290                 23295             


Gly Thr   Met Tyr Tyr Phe Arg   Val Leu Pro Glu Asn   Ile Tyr Gly 
    23300                 23305                 23310             


Ile Gly   Glu Pro Cys Glu Thr   Ser Asp Ala Val Leu   Val Ser Glu 
    23315                 23320                 23325             


Val Pro   Leu Val Pro Ala Lys   Leu Glu Val Val Asp   Val Thr Lys 
    23330                 23335                 23340             


Ser Thr   Val Thr Leu Ala Trp   Glu Lys Pro Leu Tyr   Asp Gly Gly 
    23345                 23350                 23355             


Ser Arg   Leu Thr Gly Tyr Val   Leu Glu Ala Cys Lys   Ala Gly Thr 
    23360                 23365                 23370             


Glu Arg   Trp Met Lys Val Val   Thr Leu Lys Pro Thr   Val Leu Glu 
    23375                 23380                 23385             


His Thr   Val Thr Ser Leu Asn   Glu Gly Glu Gln Tyr   Leu Phe Arg 
    23390                 23395                 23400             


Ile Arg   Ala Gln Asn Glu Lys   Gly Val Ser Glu Pro   Arg Glu Thr 
    23405                 23410                 23415             


Val Thr   Ala Val Thr Val Gln   Asp Leu Arg Val Leu   Pro Thr Ile 
    23420                 23425                 23430             


Asp Leu   Ser Thr Met Pro Gln   Lys Thr Ile His Val   Pro Ala Gly 
    23435                 23440                 23445             


Arg Pro   Val Glu Leu Val Ile   Pro Ile Ala Gly Arg   Pro Pro Pro 
    23450                 23455                 23460             


Ala Ala   Ser Trp Phe Phe Ala   Gly Ser Lys Leu Arg   Glu Ser Glu 
    23465                 23470                 23475             


Arg Val   Thr Val Glu Thr His   Thr Lys Val Ala Lys   Leu Thr Ile 
    23480                 23485                 23490             


Arg Glu   Thr Thr Ile Arg Asp   Thr Gly Glu Tyr Thr   Leu Glu Leu 
    23495                 23500                 23505             


Lys Asn   Val Thr Gly Thr Thr   Ser Glu Thr Ile Lys   Val Ile Ile 
    23510                 23515                 23520             


Leu Asp   Lys Pro Gly Pro Pro   Thr Gly Pro Ile Lys   Ile Asp Glu 
    23525                 23530                 23535             


Ile Asp   Ala Thr Ser Ile Thr   Ile Ser Trp Glu Pro   Pro Glu Leu 
    23540                 23545                 23550             


Asp Gly   Gly Ala Pro Leu Ser   Gly Tyr Val Val Glu   Gln Arg Asp 
    23555                 23560                 23565             


Ala His   Arg Pro Gly Trp Leu   Pro Val Ser Glu Ser   Val Thr Arg 
    23570                 23575                 23580             


Ser Thr   Phe Lys Phe Thr Arg   Leu Thr Glu Gly Asn   Glu Tyr Val 
    23585                 23590                 23595             


Phe Arg   Val Ala Ala Thr Asn   Arg Phe Gly Ile Gly   Ser Tyr Leu 
    23600                 23605                 23610             


Gln Ser   Glu Val Ile Glu Cys   Arg Ser Ser Ile Arg   Ile Pro Gly 
    23615                 23620                 23625             


Pro Pro   Glu Thr Leu Gln Ile   Phe Asp Val Ser Arg   Asp Gly Met 
    23630                 23635                 23640             


Thr Leu   Thr Trp Tyr Pro Pro   Glu Asp Asp Gly Gly   Ser Gln Val 
    23645                 23650                 23655             


Thr Gly   Tyr Ile Val Glu Arg   Lys Glu Val Arg Ala   Asp Arg Trp 
    23660                 23665                 23670             


Val Arg   Val Asn Lys Val Pro   Val Thr Met Thr Arg   Tyr Arg Ser 
    23675                 23680                 23685             


Thr Gly   Leu Thr Glu Gly Leu   Glu Tyr Glu His Arg   Val Thr Ala 
    23690                 23695                 23700             


Ile Asn   Ala Arg Gly Ser Gly   Lys Pro Ser Arg Pro   Ser Lys Pro 
    23705                 23710                 23715             


Ile Val   Ala Met Asp Pro Ile   Ala Pro Pro Gly Lys   Pro Gln Asn 
    23720                 23725                 23730             


Pro Arg   Val Thr Asp Thr Thr   Arg Thr Ser Val Ser   Leu Ala Trp 
    23735                 23740                 23745             


Ser Val   Pro Glu Asp Glu Gly   Gly Ser Lys Val Thr   Gly Tyr Leu 
    23750                 23755                 23760             


Ile Glu   Met Gln Lys Val Asp   Gln His Glu Trp Thr   Lys Cys Asn 
    23765                 23770                 23775             


Thr Thr   Pro Thr Lys Ile Arg   Glu Tyr Thr Leu Thr   His Leu Pro 
    23780                 23785                 23790             


Gln Gly   Ala Glu Tyr Arg Phe   Arg Val Leu Ala Cys   Asn Ala Gly 
    23795                 23800                 23805             


Gly Pro   Gly Glu Pro Ala Glu   Val Pro Gly Thr Val   Lys Val Thr 
    23810                 23815                 23820             


Glu Met   Leu Glu Tyr Pro Asp   Tyr Glu Leu Asp Glu   Arg Tyr Gln 
    23825                 23830                 23835             


Glu Gly   Ile Phe Val Arg Gln   Gly Gly Val Ile Arg   Leu Thr Ile 
    23840                 23845                 23850             


Pro Ile   Lys Gly Lys Pro Phe   Pro Ile Cys Lys Trp   Thr Lys Glu 
    23855                 23860                 23865             


Gly Gln   Asp Ile Ser Lys Arg   Ala Met Ile Ala Thr   Ser Glu Thr 
    23870                 23875                 23880             


His Thr   Glu Leu Val Ile Lys   Glu Ala Asp Arg Gly   Asp Ser Gly 
    23885                 23890                 23895             


Thr Tyr   Asp Leu Val Leu Glu   Asn Lys Cys Gly Lys   Lys Ala Val 
    23900                 23905                 23910             


Tyr Ile   Lys Val Arg Val Ile   Gly Ser Pro Asn Ser   Pro Glu Gly 
    23915                 23920                 23925             


Pro Leu   Glu Tyr Asp Asp Ile   Gln Val Arg Ser Val   Arg Val Ser 
    23930                 23935                 23940             


Trp Arg   Pro Pro Ala Asp Asp   Gly Gly Ala Asp Ile   Leu Gly Tyr 
    23945                 23950                 23955             


Ile Leu   Glu Arg Arg Glu Val   Pro Lys Ala Ala Trp   Tyr Thr Ile 
    23960                 23965                 23970             


Asp Ser   Arg Val Arg Gly Thr   Ser Leu Val Val Lys   Gly Leu Lys 
    23975                 23980                 23985             


Glu Asn   Val Glu Tyr His Phe   Arg Val Ser Ala Glu   Asn Gln Phe 
    23990                 23995                 24000             


Gly Ile   Ser Lys Pro Leu Lys   Ser Glu Glu Pro Val   Thr Pro Lys 
    24005                 24010                 24015             


Thr Pro   Leu Asn Pro Pro Glu   Pro Pro Ser Asn Pro   Pro Glu Val 
    24020                 24025                 24030             


Leu Asp   Val Thr Lys Ser Ser   Val Ser Leu Ser Trp   Ser Arg Pro 
    24035                 24040                 24045             


Lys Asp   Asp Gly Gly Ser Arg   Val Thr Gly Tyr Tyr   Ile Glu Arg 
    24050                 24055                 24060             


Lys Glu   Thr Ser Thr Asp Lys   Trp Val Arg His Asn   Lys Thr Gln 
    24065                 24070                 24075             


Ile Thr   Thr Thr Met Tyr Thr   Val Thr Gly Leu Val   Pro Asp Ala 
    24080                 24085                 24090             


Glu Tyr   Gln Phe Arg Ile Ile   Ala Gln Asn Asp Val   Gly Leu Ser 
    24095                 24100                 24105             


Glu Thr   Ser Pro Ala Ser Glu   Pro Val Val Cys Lys   Asp Pro Phe 
    24110                 24115                 24120             


Asp Lys   Pro Ser Gln Pro Gly   Glu Leu Glu Ile Leu   Ser Ile Ser 
    24125                 24130                 24135             


Lys Asp   Ser Val Thr Leu Gln   Trp Glu Lys Pro Glu   Cys Asp Gly 
    24140                 24145                 24150             


Gly Lys   Glu Ile Leu Gly Tyr   Trp Val Glu Tyr Arg   Gln Ser Gly 
    24155                 24160                 24165             


Asp Ser   Ala Trp Lys Lys Ser   Asn Lys Glu Arg Ile   Lys Asp Lys 
    24170                 24175                 24180             


Gln Phe   Thr Ile Gly Gly Leu   Leu Glu Ala Thr Glu   Tyr Glu Phe 
    24185                 24190                 24195             


Arg Val   Phe Ala Glu Asn Glu   Thr Gly Leu Ser Arg   Pro Arg Arg 
    24200                 24205                 24210             


Thr Ala   Met Ser Ile Lys Thr   Lys Leu Thr Ser Gly   Glu Ala Pro 
    24215                 24220                 24225             


Gly Ile   Arg Lys Glu Met Lys   Asp Val Thr Thr Lys   Leu Gly Glu 
    24230                 24235                 24240             


Ala Ala   Gln Leu Ser Cys Gln   Ile Val Gly Arg Pro   Leu Pro Asp 
    24245                 24250                 24255             


Ile Lys   Trp Tyr Arg Phe Gly   Lys Glu Leu Ile Gln   Ser Arg Lys 
    24260                 24265                 24270             


Tyr Lys   Met Ser Ser Asp Gly   Arg Thr His Thr Leu   Thr Val Met 
    24275                 24280                 24285             


Thr Glu   Glu Gln Glu Asp Glu   Gly Val Tyr Thr Cys   Ile Ala Thr 
    24290                 24295                 24300             


Asn Glu   Val Gly Glu Val Glu   Thr Ser Ser Lys Leu   Leu Leu Gln 
    24305                 24310                 24315             


Ala Thr   Pro Gln Phe His Pro   Gly Tyr Pro Leu Lys   Glu Lys Tyr 
    24320                 24325                 24330             


Tyr Gly   Ala Val Gly Ser Thr   Leu Arg Leu His Val   Met Tyr Ile 
    24335                 24340                 24345             


Gly Arg   Pro Val Pro Ala Met   Thr Trp Phe His Gly   Gln Lys Leu 
    24350                 24355                 24360             


Leu Gln   Asn Ser Glu Asn Ile   Thr Ile Glu Asn Thr   Glu His Tyr 
    24365                 24370                 24375             


Thr His   Leu Val Met Lys Asn   Val Gln Arg Lys Thr   His Ala Gly 
    24380                 24385                 24390             


Lys Tyr   Lys Val Gln Leu Ser   Asn Val Phe Gly Thr   Val Asp Ala 
    24395                 24400                 24405             


Ile Leu   Asp Val Glu Ile Gln   Asp Lys Pro Asp Lys   Pro Thr Gly 
    24410                 24415                 24420             


Pro Ile   Val Ile Glu Ala Leu   Leu Lys Asn Ser Ala   Val Ile Ser 
    24425                 24430                 24435             


Trp Lys   Pro Pro Ala Asp Asp   Gly Gly Ser Trp Ile   Thr Asn Tyr 
    24440                 24445                 24450             


Val Val   Glu Lys Cys Glu Ala   Lys Glu Gly Ala Glu   Trp Gln Leu 
    24455                 24460                 24465             


Val Ser   Ser Ala Ile Ser Val   Thr Thr Cys Arg Ile   Val Asn Leu 
    24470                 24475                 24480             


Thr Glu   Asn Ala Gly Tyr Tyr   Phe Arg Val Ser Ala   Gln Asn Thr 
    24485                 24490                 24495             


Phe Gly   Ile Ser Asp Pro Leu   Glu Val Ser Ser Val   Val Ile Ile 
    24500                 24505                 24510             


Lys Ser   Pro Phe Glu Lys Pro   Gly Ala Pro Gly Lys   Pro Thr Ile 
    24515                 24520                 24525             


Thr Ala   Val Thr Lys Asp Ser   Cys Val Val Ala Trp   Lys Pro Pro 
    24530                 24535                 24540             


Ala Ser   Asp Gly Gly Ala Lys   Ile Arg Asn Tyr Tyr   Leu Glu Lys 
    24545                 24550                 24555             


Arg Glu   Lys Lys Gln Asn Lys   Trp Ile Ser Val Thr   Thr Glu Glu 
    24560                 24565                 24570             


Ile Arg   Glu Thr Val Phe Ser   Val Lys Asn Leu Ile   Glu Gly Leu 
    24575                 24580                 24585             


Glu Tyr   Glu Phe Arg Val Lys   Cys Glu Asn Leu Gly   Gly Glu Ser 
    24590                 24595                 24600             


Glu Trp   Ser Glu Ile Ser Glu   Pro Ile Thr Pro Lys   Ser Asp Val 
    24605                 24610                 24615             


Pro Ile   Gln Ala Pro His Phe   Lys Glu Glu Leu Arg   Asn Leu Asn 
    24620                 24625                 24630             


Val Arg   Tyr Gln Ser Asn Ala   Thr Leu Val Cys Lys   Val Thr Gly 
    24635                 24640                 24645             


His Pro   Lys Pro Ile Val Lys   Trp Tyr Arg Gln Gly   Lys Glu Ile 
    24650                 24655                 24660             


Ile Ala   Asp Gly Leu Lys Tyr   Arg Ile Gln Glu Phe   Lys Gly Gly 
    24665                 24670                 24675             


Tyr His   Gln Leu Ile Ile Ala   Ser Val Thr Asp Asp   Asp Ala Thr 
    24680                 24685                 24690             


Val Tyr   Gln Val Arg Ala Thr   Asn Gln Gly Gly Ser   Val Ser Gly 
    24695                 24700                 24705             


Thr Ala   Ser Leu Glu Val Glu   Val Pro Ala Lys Ile   His Leu Pro 
    24710                 24715                 24720             


Lys Thr   Leu Glu Gly Met Gly   Ala Val His Ala Leu   Arg Gly Glu 
    24725                 24730                 24735             


Val Val   Ser Ile Lys Ile Pro   Phe Ser Gly Lys Pro   Asp Pro Val 
    24740                 24745                 24750             


Ile Thr   Trp Gln Lys Gly Gln   Asp Leu Ile Asp Asn   Asn Gly His 
    24755                 24760                 24765             


Tyr Gln   Val Ile Val Thr Arg   Ser Phe Thr Ser Leu   Val Phe Pro 
    24770                 24775                 24780             


Asn Gly   Val Glu Arg Lys Asp   Ala Gly Phe Tyr Val   Val Cys Ala 
    24785                 24790                 24795             


Lys Asn   Arg Phe Gly Ile Asp   Gln Lys Thr Val Glu   Leu Asp Val 
    24800                 24805                 24810             


Ala Asp   Val Pro Asp Pro Pro   Arg Gly Val Lys Val   Ser Asp Val 
    24815                 24820                 24825             


Ser Arg   Asp Ser Val Asn Leu   Thr Trp Thr Glu Pro   Ala Ser Asp 
    24830                 24835                 24840             


Gly Gly   Ser Lys Ile Thr Asn   Tyr Ile Val Glu Lys   Cys Ala Thr 
    24845                 24850                 24855             


Thr Ala   Glu Arg Trp Leu Arg   Val Gly Gln Ala Arg   Glu Thr Arg 
    24860                 24865                 24870             


Tyr Thr   Val Ile Asn Leu Phe   Gly Lys Thr Ser Tyr   Gln Phe Arg 
    24875                 24880                 24885             


Val Ile   Ala Glu Asn Lys Phe   Gly Leu Ser Lys Pro   Ser Glu Pro 
    24890                 24895                 24900             


Ser Glu   Pro Thr Ile Thr Lys   Glu Asp Lys Thr Arg   Ala Met Asn 
    24905                 24910                 24915             


Tyr Asp   Glu Glu Val Asp Glu   Thr Arg Glu Val Ser   Met Thr Lys 
    24920                 24925                 24930             


Ala Ser   His Ser Ser Thr Lys   Glu Leu Tyr Glu Lys   Tyr Met Ile 
    24935                 24940                 24945             


Ala Glu   Asp Leu Gly Arg Gly   Glu Phe Gly Ile Val   His Arg Cys 
    24950                 24955                 24960             


Val Glu   Thr Ser Ser Lys Lys   Thr Tyr Met Ala Lys   Phe Val Lys 
    24965                 24970                 24975             


Val Lys   Gly Thr Asp Gln Val   Leu Val Lys Lys Glu   Ile Ser Ile 
    24980                 24985                 24990             


Leu Asn   Ile Ala Arg His Arg   Asn Ile Leu His Leu   His Glu Ser 
    24995                 25000                 25005             


Phe Glu   Ser Met Glu Glu Leu   Val Met Ile Phe Glu   Phe Ile Ser 
    25010                 25015                 25020             


Gly Leu   Asp Ile Phe Glu Arg   Ile Asn Thr Ser Ala   Phe Glu Leu 
    25025                 25030                 25035             


Asn Glu   Arg Glu Ile Val Ser   Tyr Val His Gln Val   Cys Glu Ala 
    25040                 25045                 25050             


Leu Gln   Phe Leu His Ser His   Asn Ile Gly His Phe   Asp Ile Arg 
    25055                 25060                 25065             


Pro Glu   Asn Ile Ile Tyr Gln   Thr Arg Arg Ser Ser   Thr Ile Lys 
    25070                 25075                 25080             


Ile Ile   Glu Phe Gly Gln Ala   Arg Gln Leu Lys Pro   Gly Asp Asn 
    25085                 25090                 25095             


Phe Arg   Leu Leu Phe Thr Ala   Pro Glu Tyr Tyr Ala   Pro Glu Val 
    25100                 25105                 25110             


His Gln   His Asp Val Val Ser   Thr Ala Thr Asp Met   Trp Ser Leu 
    25115                 25120                 25125             


Gly Thr   Leu Val Tyr Val Leu   Leu Ser Gly Ile Asn   Pro Phe Leu 
    25130                 25135                 25140             


Ala Glu   Thr Asn Gln Gln Ile   Ile Glu Asn Ile Met   Asn Ala Glu 
    25145                 25150                 25155             


Tyr Thr   Phe Asp Glu Glu Ala   Phe Lys Glu Ile Ser   Ile Glu Ala 
    25160                 25165                 25170             


Met Asp   Phe Val Asp Arg Leu   Leu Val Lys Glu Arg   Lys Ser Arg 
    25175                 25180                 25185             


Met Thr   Ala Ser Glu Ala Leu   Gln His Pro Trp Leu   Lys Gln Lys 
    25190                 25195                 25200             


Ile Glu   Arg Val Ser Thr Lys   Val Ile Arg Thr Leu   Lys His Arg 
    25205                 25210                 25215             


Arg Tyr   Tyr His Thr Leu Ile   Lys Lys Asp Leu Asn   Met Val Val 
    25220                 25225                 25230             


Ser Ala   Ala Arg Ile Ser Cys   Gly Gly Ala Ile Arg   Ser Gln Lys 
    25235                 25240                 25245             


Gly Val   Ser Val Ala Lys Val   Lys Val Ala Ser Ile   Glu Ile Gly 
    25250                 25255                 25260             


Pro Val   Ser Gly Gln Ile Met   His Ala Val Gly Glu   Glu Gly Gly 
    25265                 25270                 25275             


His Val   Lys Tyr Val Cys Lys   Ile Glu Asn Tyr Asp   Gln Ser Thr 
    25280                 25285                 25290             


Gln Val   Thr Trp Tyr Phe Gly   Val Arg Gln Leu Glu   Asn Ser Glu 
    25295                 25300                 25305             


Lys Tyr   Glu Ile Thr Tyr Glu   Asp Gly Val Ala Ile   Leu Tyr Val 
    25310                 25315                 25320             


Lys Asp   Ile Thr Lys Leu Asp   Asp Gly Thr Tyr Arg   Cys Lys Val 
    25325                 25330                 25335             


Val Asn   Asp Tyr Gly Glu Asp   Ser Ser Tyr Ala Glu   Leu Phe Val 
    25340                 25345                 25350             


Lys Gly   Val Arg Glu Val Tyr   Asp Tyr Tyr Cys Arg   Arg Thr Met 
    25355                 25360                 25365             


Lys Lys   Ile Lys Arg Arg Thr   Asp Thr Met Arg Leu   Leu Glu Arg 
    25370                 25375                 25380             


Pro Pro   Glu Phe Thr Leu Pro   Leu Tyr Asn Lys Thr   Ala Tyr Val 
    25385                 25390                 25395             


Gly Glu   Asn Val Arg Phe Gly   Val Thr Ile Thr Val   His Pro Glu 
    25400                 25405                 25410             


Pro His   Val Thr Trp Tyr Lys   Ser Gly Gln Lys Ile   Lys Pro Gly 
    25415                 25420                 25425             


Asp Asn   Asp Lys Lys Tyr Thr   Phe Glu Ser Asp Lys   Gly Leu Tyr 
    25430                 25435                 25440             


Gln Leu   Thr Ile Asn Ser Val   Thr Thr Asp Asp Asp   Ala Glu Tyr 
    25445                 25450                 25455             


Thr Val   Val Ala Arg Asn Lys   Tyr Gly Glu Asp Ser   Cys Lys Ala 
    25460                 25465                 25470             


Lys Leu   Thr Val Thr Leu His   Pro Pro Pro Thr Asp   Ser Thr Leu 
    25475                 25480                 25485             


Arg Pro   Met Phe Lys Arg Leu   Leu Ala Asn Ala Glu   Cys Gln Glu 
    25490                 25495                 25500             


Gly Gln   Ser Val Cys Phe Glu   Ile Arg Val Ser Gly   Ile Pro Pro 
    25505                 25510                 25515             


Pro Thr   Leu Lys Trp Glu Lys   Asp Gly Gln Pro Leu   Ser Leu Gly 
    25520                 25525                 25530             


Pro Asn   Ile Glu Ile Ile His   Glu Gly Leu Asp Tyr   Tyr Ala Leu 
    25535                 25540                 25545             


His Ile   Arg Asp Thr Leu Pro   Glu Asp Thr Gly Tyr   Tyr Arg Val 
    25550                 25555                 25560             


Thr Ala   Thr Asn Thr Ala Gly   Ser Thr Ser Cys Gln   Ala His Leu 
    25565                 25570                 25575             


Gln Val   Glu Arg Leu Arg Tyr   Lys Lys Gln Glu Phe   Lys Ser Lys 
    25580                 25585                 25590             


Glu Glu   His Glu Arg His Val   Gln Lys Gln Ile Asp   Lys Thr Leu 
    25595                 25600                 25605             


Arg Met   Ala Glu Ile Leu Ser   Gly Thr Glu Ser Val   Pro Leu Thr 
    25610                 25615                 25620             


Gln Val   Ala Lys Glu Ala Leu   Arg Glu Ala Ala Val   Leu Tyr Lys 
    25625                 25630                 25635             


Pro Ala   Val Ser Thr Lys Thr   Val Lys Gly Glu Phe   Arg Leu Glu 
    25640                 25645                 25650             


Ile Glu   Glu Lys Lys Glu Glu   Arg Lys Leu Arg Met   Pro Tyr Asp 
    25655                 25660                 25665             


Val Pro   Glu Pro Arg Lys Tyr   Lys Gln Thr Thr Ile   Glu Glu Asp 
    25670                 25675                 25680             


Gln Arg   Ile Lys Gln Phe Val   Pro Met Ser Asp Met   Lys Trp Tyr 
    25685                 25690                 25695             


Lys Lys   Ile Arg Asp Gln Tyr   Glu Met Pro Gly Lys   Leu Asp Arg 
    25700                 25705                 25710             


Val Val   Gln Lys Arg Pro Lys   Arg Ile Arg Leu Ser   Arg Trp Glu 
    25715                 25720                 25725             


Gln Phe   Tyr Val Met Pro Leu   Pro Arg Ile Thr Asp   Gln Tyr Arg 
    25730                 25735                 25740             


Pro Lys   Trp Arg Ile Pro Lys   Leu Ser Gln Asp Asp   Leu Glu Ile 
    25745                 25750                 25755             


Val Arg   Pro Ala Arg Arg Arg   Thr Pro Ser Pro Asp   Tyr Asp Phe 
    25760                 25765                 25770             


Tyr Tyr   Arg Pro Arg Arg Arg   Ser Leu Gly Asp Ile   Ser Asp Glu 
    25775                 25780                 25785             


Glu Leu   Leu Leu Pro Ile Asp   Asp Tyr Leu Ala Met   Lys Arg Thr 
    25790                 25795                 25800             


Glu Glu   Glu Arg Leu Arg Leu   Glu Glu Glu Leu Glu   Leu Gly Phe 
    25805                 25810                 25815             


Ser Ala   Ser Pro Pro Ser Arg   Ser Pro Pro His Phe   Glu Leu Ser 
    25820                 25825                 25830             


Ser Leu   Arg Tyr Ser Ser Pro   Gln Ala His Val Lys   Val Glu Glu 
    25835                 25840                 25845             


Thr Arg   Lys Asp Phe Arg Tyr   Ser Thr Tyr His Ile   Pro Thr Lys 
    25850                 25855                 25860             


Ala Glu   Ala Ser Thr Ser Tyr   Ala Glu Leu Arg Glu   Arg His Ala 
    25865                 25870                 25875             


Gln Ala   Ala Tyr Arg Gln Pro   Lys Gln Arg Gln Arg   Ile Met Ala 
    25880                 25885                 25890             


Glu Arg   Glu Asp Glu Glu Leu   Leu Arg Pro Val Thr   Thr Thr Gln 
    25895                 25900                 25905             


His Leu   Ser Glu Tyr Lys Ser   Glu Leu Asp Phe Met   Ser Lys Glu 
    25910                 25915                 25920             


Glu Lys   Ser Arg Lys Lys Ser   Arg Arg Gln Arg Glu   Val Thr Glu 
    25925                 25930                 25935             


Ile Thr   Glu Ile Glu Glu Glu   Tyr Glu Ile Ser Lys   His Ala Gln 
    25940                 25945                 25950             


Arg Glu   Ser Ser Ser Ser Ala   Ser Arg Leu Leu Arg   Arg Arg Arg 
    25955                 25960                 25965             


Ser Leu   Ser Pro Thr Tyr Ile   Glu Leu Met Arg Pro   Val Ser Glu 
    25970                 25975                 25980             


Leu Ile   Arg Ser Arg Pro Gln   Pro Ala Glu Glu Tyr   Glu Asp Asp 
    25985                 25990                 25995             


Thr Glu   Arg Arg Ser Pro Thr   Pro Glu Arg Thr Arg   Pro Arg Ser 
    26000                 26005                 26010             


Pro Ser   Pro Val Ser Ser Glu   Arg Ser Leu Ser Arg   Phe Glu Arg 
    26015                 26020                 26025             


Ser Ala   Arg Phe Asp Ile Phe   Ser Arg Tyr Glu Ser   Met Lys Ala 
    26030                 26035                 26040             


Ala Leu   Lys Thr Gln Lys Thr   Ser Glu Arg Lys Tyr   Glu Val Leu 
    26045                 26050                 26055             


Ser Gln   Gln Pro Phe Thr Leu   Asp His Ala Pro Arg   Ile Thr Leu 
    26060                 26065                 26070             


Arg Met   Arg Ser His Arg Val   Pro Cys Gly Gln Asn   Thr Arg Phe 
    26075                 26080                 26085             


Ile Leu   Asn Val Gln Ser Lys   Pro Thr Ala Glu Val   Lys Trp Tyr 
    26090                 26095                 26100             


His Asn   Gly Val Glu Leu Gln   Glu Ser Ser Lys Ile   His Tyr Thr 
    26105                 26110                 26115             


Asn Thr   Ser Gly Val Leu Thr   Leu Glu Ile Leu Asp   Cys His Thr 
    26120                 26125                 26130             


Asp Asp   Ser Gly Thr Tyr Arg   Ala Val Cys Thr Asn   Tyr Lys Gly 
    26135                 26140                 26145             


Glu Ala   Ser Asp Tyr Ala Thr   Leu Asp Val Thr Gly   Gly Asp Tyr 
    26150                 26155                 26160             


Thr Thr   Tyr Ala Ser Gln Arg   Arg Asp Glu Glu Val   Pro Arg Ser 
    26165                 26170                 26175             


Val Phe   Pro Glu Leu Thr Arg   Thr Glu Ala Tyr Ala   Val Ser Ser 
    26180                 26185                 26190             


Phe Lys   Lys Thr Ser Glu Met   Glu Ala Ser Ser Ser   Val Arg Glu 
    26195                 26200                 26205             


Val Lys   Ser Gln Met Thr Glu   Thr Arg Glu Ser Leu   Ser Ser Tyr 
    26210                 26215                 26220             


Glu His   Ser Ala Ser Ala Glu   Met Lys Ser Ala Ala   Leu Glu Glu 
    26225                 26230                 26235             


Lys Ser   Leu Glu Glu Lys Ser   Thr Thr Arg Lys Ile   Lys Thr Thr 
    26240                 26245                 26250             


Leu Ala   Ala Arg Ile Leu Thr   Lys Pro Arg Ser Met   Thr Val Tyr 
    26255                 26260                 26265             


Glu Gly   Glu Ser Ala Arg Phe   Ser Cys Asp Thr Asp   Gly Glu Pro 
    26270                 26275                 26280             


Val Pro   Thr Val Thr Trp Leu   Arg Lys Gly Gln Val   Leu Ser Thr 
    26285                 26290                 26295             


Ser Ala   Arg His Gln Val Thr   Thr Thr Lys Tyr Lys   Ser Thr Phe 
    26300                 26305                 26310             


Glu Ile   Ser Ser Val Gln Ala   Ser Asp Glu Gly Asn   Tyr Ser Val 
    26315                 26320                 26325             


Val Val   Glu Asn Ser Glu Gly   Lys Gln Glu Ala Glu   Phe Thr Leu 
    26330                 26335                 26340             


Thr Ile   Gln Lys Ala Arg Val   Thr Glu Lys Ala Val   Thr Ser Pro 
    26345                 26350                 26355             


Pro Arg   Val Lys Ser Pro Glu   Pro Arg Val Lys Ser   Pro Glu Ala 
    26360                 26365                 26370             


Val Lys   Ser Pro Lys Arg Val   Lys Ser Pro Glu Pro   Ser His Pro 
    26375                 26380                 26385             


Lys Ala   Val Ser Pro Thr Glu   Thr Lys Pro Thr Pro   Thr Glu Lys 
    26390                 26395                 26400             


Val Gln   His Leu Pro Val Ser   Ala Pro Pro Lys Ile   Thr Gln Phe 
    26405                 26410                 26415             


Leu Lys   Ala Glu Ala Ser Lys   Glu Ile Ala Lys Leu   Thr Cys Val 
    26420                 26425                 26430             


Val Glu   Ser Ser Val Leu Arg   Ala Lys Glu Val Thr   Trp Tyr Lys 
    26435                 26440                 26445             


Asp Gly   Lys Lys Leu Lys Glu   Asn Gly His Phe Gln   Phe His Tyr 
    26450                 26455                 26460             


Ser Ala   Asp Gly Thr Tyr Glu   Leu Lys Ile Asn Asn   Leu Thr Glu 
    26465                 26470                 26475             


Ser Asp   Gln Gly Glu Tyr Val   Cys Glu Ile Ser Gly   Glu Gly Gly 
    26480                 26485                 26490             


Thr Ser   Lys Thr Asn Leu Gln   Phe Met Gly Gln Ala   Phe Lys Ser 
    26495                 26500                 26505             


Ile His   Glu Lys Val Ser Lys   Ile Ser Glu Thr Lys   Lys Ser Asp 
    26510                 26515                 26520             


Gln Lys   Thr Thr Glu Ser Thr   Val Thr Arg Lys Thr   Glu Pro Lys 
    26525                 26530                 26535             


Ala Pro   Glu Pro Ile Ser Ser   Lys Pro Val Ile Val   Thr Gly Leu 
    26540                 26545                 26550             


Gln Asp   Thr Thr Val Ser Ser   Asp Ser Val Ala Lys   Phe Ala Val 
    26555                 26560                 26565             


Lys Ala   Thr Gly Glu Pro Arg   Pro Thr Ala Ile Trp   Thr Lys Asp 
    26570                 26575                 26580             


Gly Lys   Ala Ile Thr Gln Gly   Gly Lys Tyr Lys Leu   Ser Glu Asp 
    26585                 26590                 26595             


Lys Gly   Gly Phe Phe Leu Glu   Ile His Lys Thr Asp   Thr Ser Asp 
    26600                 26605                 26610             


Ser Gly   Leu Tyr Thr Cys Thr   Val Lys Asn Ser Ala   Gly Ser Val 
    26615                 26620                 26625             


Ser Ser   Ser Cys Lys Leu Thr   Ile Lys Ala Ile Lys   Asp Thr Glu 
    26630                 26635                 26640             


Ala Gln   Lys Val Ser Thr Gln   Lys Thr Ser Glu Ile   Thr Pro Gln 
    26645                 26650                 26655             


Lys Lys   Ala Val Val Gln Glu   Glu Ile Ser Gln Lys   Ala Leu Arg 
    26660                 26665                 26670             


Ser Glu   Glu Ile Lys Met Ser   Glu Ala Lys Ser Gln   Glu Lys Leu 
    26675                 26680                 26685             


Ala Leu   Lys Glu Glu Ala Ser   Lys Val Leu Ile Ser   Glu Glu Val 
    26690                 26695                 26700             


Lys Lys   Ser Ala Ala Thr Ser   Leu Glu Lys Ser Ile   Val His Glu 
    26705                 26710                 26715             


Glu Ile   Thr Lys Thr Ser Gln   Ala Ser Glu Glu Val   Arg Thr His 
    26720                 26725                 26730             


Ala Glu   Ile Lys Ala Phe Ser   Thr Gln Met Ser Ile   Asn Glu Gly 
    26735                 26740                 26745             


Gln Arg   Leu Val Leu Lys Ala   Asn Ile Ala Gly Ala   Thr Asp Val 
    26750                 26755                 26760             


Lys Trp   Val Leu Asn Gly Val   Glu Leu Thr Asn Ser   Glu Glu Tyr 
    26765                 26770                 26775             


Arg Tyr   Gly Val Ser Gly Ser   Asp Gln Thr Leu Thr   Ile Lys Gln 
    26780                 26785                 26790             


Ala Ser   His Arg Asp Glu Gly   Ile Leu Thr Cys Ile   Ser Lys Thr 
    26795                 26800                 26805             


Lys Glu   Gly Ile Val Lys Cys   Gln Tyr Asp Leu Thr   Leu Ser Lys 
    26810                 26815                 26820             


Glu Leu   Ser Asp Ala Pro Ala   Phe Ile Ser Gln Pro   Arg Ser Gln 
    26825                 26830                 26835             


Asn Ile   Asn Glu Gly Gln Asn   Val Leu Phe Thr Cys   Glu Ile Ser 
    26840                 26845                 26850             


Gly Glu   Pro Ser Pro Glu Ile   Glu Trp Phe Lys Asn   Asn Leu Pro 
    26855                 26860                 26865             


Ile Ser   Ile Ser Ser Asn Val   Ser Ile Ser Arg Ser   Arg Asn Val 
    26870                 26875                 26880             


Tyr Ser   Leu Glu Ile Arg Asn   Ala Ser Val Ser Asp   Ser Gly Lys 
    26885                 26890                 26895             


Tyr Thr   Ile Lys Ala Lys Asn   Phe Arg Gly Gln Cys   Ser Ala Thr 
    26900                 26905                 26910             


Ala Ser   Leu Met Val Leu Pro   Leu Val Glu Glu Pro   Ser Arg Glu 
    26915                 26920                 26925             


Val Val   Leu Arg Thr Ser Gly   Asp Thr Ser Leu Gln   Gly Ser Phe 
    26930                 26935                 26940             


Ser Ser   Gln Ser Val Gln Met   Ser Ala Ser Lys Gln   Glu Ala Ser 
    26945                 26950                 26955             


Phe Ser   Ser Phe Ser Ser Ser   Ser Ala Ser Ser Met   Thr Glu Met 
    26960                 26965                 26970             


Lys Phe   Ala Ser Met Ser Ala   Gln Ser Met Ser Ser   Met Gln Glu 
    26975                 26980                 26985             


Ser Phe   Val Glu Met Ser Ser   Ser Ser Phe Met Gly   Ile Ser Asn 
    26990                 26995                 27000             


Met Thr   Gln Leu Glu Ser Ser   Thr Ser Lys Met Leu   Lys Ala Gly 
    27005                 27010                 27015             


Ile Arg   Gly Ile Pro Pro Lys   Ile Glu Ala Leu Pro   Ser Asp Ile 
    27020                 27025                 27030             


Ser Ile   Asp Glu Gly Lys Val   Leu Thr Val Ala Cys   Ala Phe Thr 
    27035                 27040                 27045             


Gly Glu   Pro Thr Pro Glu Val   Thr Trp Ser Cys Gly   Gly Arg Lys 
    27050                 27055                 27060             


Ile His   Ser Gln Glu Gln Gly   Arg Phe His Ile Glu   Asn Thr Asp 
    27065                 27070                 27075             


Asp Leu   Thr Thr Leu Ile Ile   Met Asp Val Gln Lys   Gln Asp Gly 
    27080                 27085                 27090             


Gly Leu   Tyr Thr Leu Ser Leu   Gly Asn Glu Phe Gly   Ser Asp Ser 
    27095                 27100                 27105             


Ala Thr   Val Asn Ile His Ile   Arg Ser Ile 
    27110                 27115             


<210>  7667
<211>  34350
<212>  PRT
<213>  Homo sapiens

<400>  7667

Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro Pro Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Arg Gln Glu Thr Glu 
545                 550                 555                 560 


Ile Thr Ala Ala Ser Met Val Val Val Ala Thr Ala Lys Ser Thr Lys 
                565                 570                 575     


Leu Glu Thr Val Pro Gly Ala Gln Glu Glu Thr Thr Thr Gln Gln Asp 
            580                 585                 590         


Gln Met His Leu Ser Tyr Glu Lys Ile Met Lys Glu Thr Arg Lys Thr 
        595                 600                 605             


Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu Gln Asp 
    610                 615                 620                 


Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu Gln Val 
625                 630                 635                 640 


Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr Ala Leu 
                645                 650                 655     


Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu Thr Ile 
            660                 665                 670         


Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile Gln Val 
        675                 680                 685             


Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val Ala Thr 
    690                 695                 700                 


Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg Glu Pro 
705                 710                 715                 720 


Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu Tyr Gly 
                725                 730                 735     


Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro Gln Arg 
            740                 745                 750         


Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro Arg Val 
        755                 760                 765             


Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln Lys Gly 
    770                 775                 780                 


Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr Thr Glu 
785                 790                 795                 800 


Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro His Phe 
                805                 810                 815     


Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr Glu Ala 
            820                 825                 830         


Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu Ser Ala 
        835                 840                 845             


Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro Thr Val 
    850                 855                 860                 


Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu Pro Gln 
865                 870                 875                 880 


Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala Gly Val 
                885                 890                 895     


Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr Val Arg 
            900                 905                 910         


Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val Thr Glu 
        915                 920                 925             


Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro Pro Thr 
    930                 935                 940                 


Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu Ser Val 
945                 950                 955                 960 


Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val Thr Trp 
                965                 970                 975     


Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln Ile Thr 
            980                 985                 990         


Phe Gln Ser Gly Ile Ala Arg Leu  Met Ile Arg Glu Ala  Phe Ala Glu 
        995                 1000                 1005             


Asp Ser  Gly Arg Phe Thr Cys  Ser Ala Val Asn Glu  Ala Gly Thr 
    1010                 1015                 1020             


Val Ser  Thr Ser Cys Tyr Leu  Ala Val Gln Val Ser  Glu Glu Phe 
    1025                 1030                 1035             


Glu Lys  Glu Thr Thr Ala Val  Thr Glu Lys Phe Thr  Thr Glu Glu 
    1040                 1045                 1050             


Lys Arg  Phe Val Glu Ser Arg  Asp Val Val Met Thr  Asp Thr Ser 
    1055                 1060                 1065             


Leu Thr  Glu Glu Gln Ala Gly  Pro Gly Glu Pro Ala  Ala Pro Tyr 
    1070                 1075                 1080             


Phe Ile  Thr Lys Pro Val Val  Gln Lys Leu Val Glu  Gly Gly Ser 
    1085                 1090                 1095             


Val Val  Phe Gly Cys Gln Val  Gly Gly Asn Pro Lys  Pro His Val 
    1100                 1105                 1110             


Tyr Trp  Lys Lys Ser Gly Val  Pro Leu Thr Thr Gly  Tyr Arg Tyr 
    1115                 1120                 1125             


Lys Val  Ser Tyr Asn Lys Gln  Thr Gly Glu Cys Lys  Leu Val Ile 
    1130                 1135                 1140             


Ser Met  Thr Phe Ala Asp Asp  Ala Gly Glu Tyr Thr  Ile Val Val 
    1145                 1150                 1155             


Arg Asn  Lys His Gly Glu Thr  Ser Ala Ser Ala Ser  Leu Leu Glu 
    1160                 1165                 1170             


Glu Ala  Asp Tyr Glu Leu Leu  Met Lys Ser Gln Gln  Glu Met Leu 
    1175                 1180                 1185             


Tyr Gln  Thr Gln Val Thr Ala  Phe Val Gln Glu Pro  Lys Val Gly 
    1190                 1195                 1200             


Glu Thr  Ala Pro Gly Phe Val  Tyr Ser Glu Tyr Glu  Lys Glu Tyr 
    1205                 1210                 1215             


Glu Lys  Glu Gln Ala Leu Ile  Arg Lys Lys Met Ala  Lys Asp Thr 
    1220                 1225                 1230             


Val Val  Val Arg Thr Tyr Val  Glu Asp Gln Glu Phe  His Ile Ser 
    1235                 1240                 1245             


Ser Phe  Glu Glu Arg Leu Ile  Lys Glu Ile Glu Tyr  Arg Ile Ile 
    1250                 1255                 1260             


Lys Thr  Thr Leu Glu Glu Leu  Leu Glu Glu Asp Gly  Glu Glu Lys 
    1265                 1270                 1275             


Met Ala  Val Asp Ile Ser Glu  Ser Glu Ala Val Glu  Ser Gly Phe 
    1280                 1285                 1290             


Asp Leu  Arg Ile Lys Asn Tyr  Arg Ile Leu Glu Gly  Met Gly Val 
    1295                 1300                 1305             


Thr Phe  His Cys Lys Met Ser  Gly Tyr Pro Leu Pro  Lys Ile Ala 
    1310                 1315                 1320             


Trp Tyr  Lys Asp Gly Lys Arg  Ile Lys His Gly Glu  Arg Tyr Gln 
    1325                 1330                 1335             


Met Asp  Phe Leu Gln Asp Gly  Arg Ala Ser Leu Arg  Ile Pro Val 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Glu Gly  Ile Tyr Thr Ala Phe  Ala Ser Asn 
    1355                 1360                 1365             


Ile Lys  Gly Asn Ala Ile Cys  Ser Gly Lys Leu Tyr  Val Glu Pro 
    1370                 1375                 1380             


Ala Ala  Pro Leu Gly Ala Pro  Thr Tyr Ile Pro Thr  Leu Glu Pro 
    1385                 1390                 1395             


Val Ser  Arg Ile Arg Ser Leu  Ser Pro Arg Ser Val  Ser Arg Ser 
    1400                 1405                 1410             


Pro Ile  Arg Met Ser Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser 
    1415                 1420                 1425             


Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser Pro Gly  Arg Arg Leu 
    1430                 1435                 1440             


Glu Glu  Thr Asp Glu Ser Gln  Leu Glu Arg Leu Tyr  Lys Pro Val 
    1445                 1450                 1455             


Phe Val  Leu Lys Pro Val Ser  Phe Lys Cys Leu Glu  Gly Gln Thr 
    1460                 1465                 1470             


Ala Arg  Phe Asp Leu Lys Val  Val Gly Arg Pro Met  Pro Glu Thr 
    1475                 1480                 1485             


Phe Trp  Phe His Asp Gly Gln  Gln Ile Val Asn Asp  Tyr Thr His 
    1490                 1495                 1500             


Lys Val  Val Ile Lys Glu Asp  Gly Thr Gln Ser Leu  Ile Ile Val 
    1505                 1510                 1515             


Pro Ala  Thr Pro Ser Asp Ser  Gly Glu Trp Thr Val  Val Ala Gln 
    1520                 1525                 1530             


Asn Arg  Ala Gly Arg Ser Ser  Ile Ser Val Ile Leu  Thr Val Glu 
    1535                 1540                 1545             


Ala Val  Glu His Gln Val Lys  Pro Met Phe Val Glu  Lys Leu Lys 
    1550                 1555                 1560             


Asn Val  Asn Ile Lys Glu Gly  Ser Arg Leu Glu Met  Lys Val Arg 
    1565                 1570                 1575             


Ala Thr  Gly Asn Pro Asn Pro  Asp Ile Val Trp Leu  Lys Asn Ser 
    1580                 1585                 1590             


Asp Ile  Ile Val Pro His Lys  Tyr Pro Lys Ile Arg  Ile Glu Gly 
    1595                 1600                 1605             


Thr Lys  Gly Glu Ala Ala Leu  Lys Ile Asp Ser Thr  Val Ser Gln 
    1610                 1615                 1620             


Asp Ser  Ala Trp Tyr Thr Ala  Thr Ala Ile Asn Lys  Ala Gly Arg 
    1625                 1630                 1635             


Asp Thr  Thr Arg Cys Lys Val  Asn Val Glu Val Glu  Phe Ala Glu 
    1640                 1645                 1650             


Pro Glu  Pro Glu Arg Lys Leu  Ile Ile Pro Arg Gly  Thr Tyr Arg 
    1655                 1660                 1665             


Ala Lys  Glu Ile Ala Ala Pro  Glu Leu Glu Pro Leu  His Leu Arg 
    1670                 1675                 1680             


Tyr Gly  Gln Glu Gln Trp Glu  Glu Gly Asp Leu Tyr  Asp Lys Glu 
    1685                 1690                 1695             


Lys Gln  Gln Lys Pro Phe Phe  Lys Lys Lys Leu Thr  Ser Leu Arg 
    1700                 1705                 1710             


Leu Lys  Arg Phe Gly Pro Ala  His Phe Glu Cys Arg  Leu Thr Pro 
    1715                 1720                 1725             


Ile Gly  Asp Pro Thr Met Val  Val Glu Trp Leu His  Asp Gly Lys 
    1730                 1735                 1740             


Pro Leu  Glu Ala Ala Asn Arg  Leu Arg Met Ile Asn  Glu Phe Gly 
    1745                 1750                 1755             


Tyr Cys  Ser Leu Asp Tyr Gly  Val Ala Tyr Ser Arg  Asp Ser Gly 
    1760                 1765                 1770             


Ile Ile  Thr Cys Arg Ala Thr  Asn Lys Tyr Gly Thr  Asp His Thr 
    1775                 1780                 1785             


Ser Ala  Thr Leu Ile Val Lys  Asp Glu Lys Ser Leu  Val Glu Glu 
    1790                 1795                 1800             


Ser Gln  Leu Pro Glu Gly Arg  Lys Gly Leu Gln Arg  Ile Glu Glu 
    1805                 1810                 1815             


Leu Glu  Arg Met Ala His Glu  Gly Ala Leu Thr Gly  Val Thr Thr 
    1820                 1825                 1830             


Asp Gln  Lys Glu Lys Gln Lys  Pro Asp Ile Val Leu  Tyr Pro Glu 
    1835                 1840                 1845             


Pro Val  Arg Val Leu Glu Gly  Glu Thr Ala Arg Phe  Arg Cys Arg 
    1850                 1855                 1860             


Val Thr  Gly Tyr Pro Gln Pro  Lys Val Asn Trp Tyr  Leu Asn Gly 
    1865                 1870                 1875             


Gln Leu  Ile Arg Lys Ser Lys  Arg Phe Arg Val Arg  Tyr Asp Gly 
    1880                 1885                 1890             


Ile His  Tyr Leu Asp Ile Val  Asp Cys Lys Ser Tyr  Asp Thr Gly 
    1895                 1900                 1905             


Glu Val  Lys Val Thr Ala Glu  Asn Pro Glu Gly Val  Ile Glu His 
    1910                 1915                 1920             


Lys Val  Lys Leu Glu Ile Gln  Gln Arg Glu Asp Phe  Arg Ser Val 
    1925                 1930                 1935             


Leu Arg  Arg Ala Pro Glu Pro  Arg Pro Glu Phe His  Val His Glu 
    1940                 1945                 1950             


Pro Gly  Lys Leu Gln Phe Glu  Val Gln Lys Val Asp  Arg Pro Val 
    1955                 1960                 1965             


Asp Thr  Thr Glu Thr Lys Glu  Val Val Lys Leu Lys  Arg Ala Glu 
    1970                 1975                 1980             


Arg Ile  Thr His Glu Lys Val  Pro Glu Glu Ser Glu  Glu Leu Arg 
    1985                 1990                 1995             


Ser Lys  Phe Lys Arg Arg Thr  Glu Glu Gly Tyr Tyr  Glu Ala Ile 
    2000                 2005                 2010             


Thr Ala  Val Glu Leu Lys Ser  Arg Lys Lys Asp Glu  Ser Tyr Glu 
    2015                 2020                 2025             


Glu Leu  Leu Arg Lys Thr Lys  Asp Glu Leu Leu His  Trp Thr Lys 
    2030                 2035                 2040             


Glu Leu  Thr Glu Glu Glu Lys  Lys Ala Leu Ala Glu  Glu Gly Lys 
    2045                 2050                 2055             


Ile Thr  Ile Pro Thr Phe Lys  Pro Asp Lys Ile Glu  Leu Ser Pro 
    2060                 2065                 2070             


Ser Met  Glu Ala Pro Lys Ile  Phe Glu Arg Ile Gln  Ser Gln Thr 
    2075                 2080                 2085             


Val Gly  Gln Gly Ser Asp Ala  His Phe Arg Val Arg  Val Val Gly 
    2090                 2095                 2100             


Lys Pro  Asp Pro Glu Cys Glu  Trp Tyr Lys Asn Gly  Val Lys Ile 
    2105                 2110                 2115             


Glu Arg  Ser Asp Arg Ile Tyr  Trp Tyr Trp Pro Glu  Asp Asn Val 
    2120                 2125                 2130             


Cys Glu  Leu Val Ile Arg Asp  Val Thr Ala Glu Asp  Ser Ala Ser 
    2135                 2140                 2145             


Ile Met  Val Lys Ala Ile Asn  Ile Ala Gly Glu Thr  Ser Ser His 
    2150                 2155                 2160             


Ala Phe  Leu Leu Val Gln Ala  Lys Gln Leu Ile Thr  Phe Thr Gln 
    2165                 2170                 2175             


Glu Leu  Gln Asp Val Val Ala  Lys Glu Lys Asp Thr  Met Ala Thr 
    2180                 2185                 2190             


Phe Glu  Cys Glu Thr Ser Glu  Pro Phe Val Lys Val  Lys Trp Tyr 
    2195                 2200                 2205             


Lys Asp  Gly Met Glu Val His  Glu Gly Asp Lys Tyr  Arg Met His 
    2210                 2215                 2220             


Ser Asp  Arg Lys Val His Phe  Leu Ser Ile Leu Thr  Ile Asp Thr 
    2225                 2230                 2235             


Ser Asp  Ala Glu Asp Tyr Ser  Cys Val Leu Val Glu  Asp Glu Asn 
    2240                 2245                 2250             


Val Lys  Thr Thr Ala Lys Leu  Ile Val Glu Gly Ala  Val Val Glu 
    2255                 2260                 2265             


Phe Val  Lys Glu Leu Gln Asp  Ile Glu Val Pro Glu  Ser Tyr Ser 
    2270                 2275                 2280             


Gly Glu  Leu Glu Cys Ile Val  Ser Pro Glu Asn Ile  Glu Gly Lys 
    2285                 2290                 2295             


Trp Tyr  His Asn Asp Val Glu  Leu Lys Ser Asn Gly  Lys Tyr Thr 
    2300                 2305                 2310             


Ile Thr  Ser Arg Arg Gly Arg  Gln Asn Leu Thr Val  Lys Asp Val 
    2315                 2320                 2325             


Thr Lys  Glu Asp Gln Gly Glu  Tyr Ser Phe Val Ile  Asp Gly Lys 
    2330                 2335                 2340             


Lys Thr  Thr Cys Lys Leu Lys  Met Lys Pro Arg Pro  Ile Ala Ile 
    2345                 2350                 2355             


Leu Gln  Gly Leu Ser Asp Gln  Lys Val Cys Glu Gly  Asp Ile Val 
    2360                 2365                 2370             


Gln Leu  Glu Val Lys Val Ser  Leu Glu Ser Val Glu  Gly Val Trp 
    2375                 2380                 2385             


Met Lys  Asp Gly Gln Glu Val  Gln Pro Ser Asp Arg  Val His Ile 
    2390                 2395                 2400             


Val Ile  Asp Lys Gln Ser His  Met Leu Leu Ile Glu  Asp Met Thr 
    2405                 2410                 2415             


Lys Glu  Asp Ala Gly Asn Tyr  Ser Phe Thr Ile Pro  Ala Leu Gly 
    2420                 2425                 2430             


Leu Ser  Thr Ser Gly Arg Val  Ser Val Tyr Ser Val  Asp Val Ile 
    2435                 2440                 2445             


Thr Pro  Leu Lys Asp Val Asn  Val Ile Glu Gly Thr  Lys Ala Val 
    2450                 2455                 2460             


Leu Glu  Cys Lys Val Ser Val  Pro Asp Val Thr Ser  Val Lys Trp 
    2465                 2470                 2475             


Tyr Leu  Asn Asp Glu Gln Ile  Lys Pro Asp Asp Arg  Val Gln Ala 
    2480                 2485                 2490             


Ile Val  Lys Gly Thr Lys Gln  Arg Leu Val Ile Asn  Arg Thr His 
    2495                 2500                 2505             


Ala Ser  Asp Glu Gly Pro Tyr  Lys Leu Ile Val Gly  Arg Val Glu 
    2510                 2515                 2520             


Thr Asn  Cys Asn Leu Ser Val  Glu Lys Ile Lys Ile  Ile Arg Gly 
    2525                 2530                 2535             


Leu Arg  Asp Leu Thr Cys Thr  Glu Thr Gln Asn Val  Val Phe Glu 
    2540                 2545                 2550             


Val Glu  Leu Ser His Ser Gly  Ile Asp Val Leu Trp  Asn Phe Lys 
    2555                 2560                 2565             


Asp Lys  Glu Ile Lys Pro Ser  Ser Lys Tyr Lys Ile  Glu Ala His 
    2570                 2575                 2580             


Gly Lys  Ile Tyr Lys Leu Thr  Val Leu Asn Met Met  Lys Asp Asp 
    2585                 2590                 2595             


Glu Gly  Lys Tyr Thr Phe Tyr  Ala Gly Glu Asn Ile  Thr Ser Gly 
    2600                 2605                 2610             


Lys Leu  Thr Val Ala Gly Gly  Ala Ile Ser Lys Pro  Leu Thr Asp 
    2615                 2620                 2625             


Gln Thr  Val Ala Glu Ser Gln  Glu Ala Val Phe Glu  Cys Glu Val 
    2630                 2635                 2640             


Ala Asn  Pro Asp Ser Lys Gly  Glu Trp Leu Arg Asp  Gly Lys His 
    2645                 2650                 2655             


Leu Pro  Leu Thr Asn Asn Ile  Arg Ser Glu Ser Asp  Gly His Lys 
    2660                 2665                 2670             


Arg Arg  Leu Ile Ile Ala Ala  Thr Lys Leu Asp Asp  Ile Gly Glu 
    2675                 2680                 2685             


Tyr Thr  Tyr Lys Val Ala Thr  Ser Lys Thr Ser Ala  Lys Leu Lys 
    2690                 2695                 2700             


Val Glu  Ala Val Lys Ile Lys  Lys Thr Leu Lys Asn  Leu Thr Val 
    2705                 2710                 2715             


Thr Glu  Thr Gln Asp Ala Val  Phe Thr Val Glu Leu  Thr His Pro 
    2720                 2725                 2730             


Asn Val  Lys Gly Val Gln Trp  Ile Lys Asn Gly Val  Val Leu Glu 
    2735                 2740                 2745             


Ser Asn  Glu Lys Tyr Ala Ile  Ser Val Lys Gly Thr  Ile Tyr Ser 
    2750                 2755                 2760             


Leu Arg  Ile Lys Asn Cys Ala  Ile Val Asp Glu Ser  Val Tyr Gly 
    2765                 2770                 2775             


Phe Arg  Leu Gly Arg Leu Gly  Ala Ser Ala Arg Leu  His Val Glu 
    2780                 2785                 2790             


Thr Val  Lys Ile Ile Lys Lys  Pro Lys Asp Val Thr  Ala Leu Glu 
    2795                 2800                 2805             


Asn Ala  Thr Val Ala Phe Glu  Val Ser Val Ser His  Asp Thr Val 
    2810                 2815                 2820             


Pro Val  Lys Trp Phe His Lys  Ser Val Glu Ile Lys  Pro Ser Asp 
    2825                 2830                 2835             


Lys His  Arg Leu Val Ser Glu  Arg Lys Val His Lys  Leu Met Leu 
    2840                 2845                 2850             


Gln Asn  Ile Ser Pro Ser Asp  Ala Gly Glu Tyr Thr  Ala Val Val 
    2855                 2860                 2865             


Gly Gln  Leu Glu Cys Lys Ala  Lys Leu Phe Val Glu  Thr Leu His 
    2870                 2875                 2880             


Ile Thr  Lys Thr Met Lys Asn  Ile Glu Val Pro Glu  Thr Lys Thr 
    2885                 2890                 2895             


Ala Ser  Phe Glu Cys Glu Val  Ser His Phe Asn Val  Pro Ser Met 
    2900                 2905                 2910             


Trp Leu  Lys Asn Gly Val Glu  Ile Glu Met Ser Glu  Lys Phe Lys 
    2915                 2920                 2925             


Ile Val  Val Gln Gly Lys Leu  His Gln Leu Ile Ile  Met Asn Thr 
    2930                 2935                 2940             


Ser Thr  Glu Asp Ser Ala Glu  Tyr Thr Phe Val Cys  Gly Asn Asp 
    2945                 2950                 2955             


Gln Val  Ser Ala Thr Leu Thr  Val Thr Pro Ile Met  Ile Thr Ser 
    2960                 2965                 2970             


Met Leu  Lys Asp Ile Asn Ala  Glu Glu Lys Asp Thr  Ile Thr Phe 
    2975                 2980                 2985             


Glu Val  Thr Val Asn Tyr Glu  Gly Ile Ser Tyr Lys  Trp Leu Lys 
    2990                 2995                 3000             


Asn Gly  Val Glu Ile Lys Ser  Thr Asp Lys Cys Gln  Met Arg Thr 
    3005                 3010                 3015             


Lys Lys  Leu Thr His Ser Leu  Asn Ile Arg Asn Val  His Phe Gly 
    3020                 3025                 3030             


Asp Ala  Ala Asp Tyr Thr Phe  Val Ala Gly Lys Ala  Thr Ser Thr 
    3035                 3040                 3045             


Ala Thr  Leu Tyr Val Glu Ala  Arg His Ile Glu Phe  Arg Lys His 
    3050                 3055                 3060             


Ile Lys  Asp Ile Lys Val Leu  Glu Lys Lys Arg Ala  Met Phe Glu 
    3065                 3070                 3075             


Cys Glu  Val Ser Glu Pro Asp  Ile Thr Val Gln Trp  Met Lys Asp 
    3080                 3085                 3090             


Asp Gln  Glu Leu Gln Ile Thr  Asp Arg Ile Lys Ile  Gln Lys Glu 
    3095                 3100                 3105             


Lys Tyr  Val His Arg Leu Leu  Ile Pro Ser Thr Arg  Met Ser Asp 
    3110                 3115                 3120             


Ala Gly  Lys Tyr Thr Val Val  Ala Gly Gly Asn Val  Ser Thr Ala 
    3125                 3130                 3135             


Lys Leu  Phe Val Glu Gly Arg  Asp Val Arg Ile Arg  Ser Ile Lys 
    3140                 3145                 3150             


Lys Glu  Val Gln Val Ile Glu  Lys Gln Arg Ala Val  Val Glu Phe 
    3155                 3160                 3165             


Glu Val  Asn Glu Asp Asp Val  Asp Ala His Trp Tyr  Lys Asp Gly 
    3170                 3175                 3180             


Ile Glu  Ile Asn Phe Gln Val  Gln Glu Arg His Lys  Tyr Val Val 
    3185                 3190                 3195             


Glu Arg  Arg Ile His Arg Met  Phe Ile Ser Glu Thr  Arg Gln Ser 
    3200                 3205                 3210             


Asp Ala  Gly Glu Tyr Thr Phe  Val Ala Gly Arg Asn  Arg Ser Ser 
    3215                 3220                 3225             


Val Thr  Leu Tyr Val Asn Ala  Pro Glu Pro Pro Gln  Val Leu Gln 
    3230                 3235                 3240             


Glu Leu  Gln Pro Val Thr Val  Gln Ser Gly Lys Pro  Ala Arg Phe 
    3245                 3250                 3255             


Cys Ala  Val Ile Ser Gly Arg  Pro Gln Pro Lys Ile  Ser Trp Tyr 
    3260                 3265                 3270             


Lys Glu  Glu Gln Leu Leu Ser  Thr Gly Phe Lys Cys  Lys Phe Leu 
    3275                 3280                 3285             


His Asp  Gly Gln Glu Tyr Thr  Leu Leu Leu Ile Glu  Ala Phe Pro 
    3290                 3295                 3300             


Glu Asp  Ala Ala Val Tyr Thr  Cys Glu Ala Lys Asn  Asp Tyr Gly 
    3305                 3310                 3315             


Val Ala  Thr Thr Ser Ala Ser  Leu Ser Val Glu Val  Pro Glu Val 
    3320                 3325                 3330             


Val Ser  Pro Asp Gln Glu Met  Pro Val Tyr Pro Pro  Ala Ile Ile 
    3335                 3340                 3345             


Thr Pro  Leu Gln Asp Thr Val  Thr Ser Glu Gly Gln  Pro Ala Arg 
    3350                 3355                 3360             


Phe Gln  Cys Arg Val Ser Gly  Thr Asp Leu Lys Val  Ser Trp Tyr 
    3365                 3370                 3375             


Ser Lys  Asp Lys Lys Ile Lys  Pro Ser Arg Phe Phe  Arg Met Thr 
    3380                 3385                 3390             


Gln Phe  Glu Asp Thr Tyr Gln  Leu Glu Ile Ala Glu  Ala Tyr Pro 
    3395                 3400                 3405             


Glu Asp  Glu Gly Thr Tyr Thr  Phe Val Ala Ser Asn  Ala Val Gly 
    3410                 3415                 3420             


Gln Val  Ser Ser Thr Ala Asn  Leu Ser Leu Glu Ala  Pro Glu Ser 
    3425                 3430                 3435             


Ile Leu  His Glu Arg Ile Glu  Gln Glu Ile Glu Met  Glu Met Lys 
    3440                 3445                 3450             


Glu Phe  Ser Ser Ser Phe Leu  Ser Ala Glu Glu Glu  Gly Leu His 
    3455                 3460                 3465             


Ser Ala  Glu Leu Gln Leu Ser  Lys Ile Asn Glu Thr  Leu Glu Leu 
    3470                 3475                 3480             


Leu Ser  Glu Ser Pro Val Tyr  Ser Thr Lys Phe Asp  Ser Glu Lys 
    3485                 3490                 3495             


Glu Gly  Thr Gly Pro Ile Phe  Ile Lys Glu Val Ser  Asn Ala Asp 
    3500                 3505                 3510             


Ile Ser  Met Gly Asp Val Ala  Thr Leu Ser Val Thr  Val Ile Gly 
    3515                 3520                 3525             


Ile Pro  Lys Pro Lys Ile Gln  Trp Phe Phe Asn Gly  Val Leu Leu 
    3530                 3535                 3540             


Thr Pro  Ser Ala Asp Tyr Lys  Phe Val Phe Asp Gly  Asp Asp His 
    3545                 3550                 3555             


Ser Leu  Ile Ile Leu Phe Thr  Lys Leu Glu Asp Glu  Gly Glu Tyr 
    3560                 3565                 3570             


Thr Cys  Met Ala Ser Asn Asp  Tyr Gly Lys Thr Ile  Cys Ser Ala 
    3575                 3580                 3585             


Tyr Leu  Lys Ile Asn Ser Lys  Gly Glu Gly His Lys  Asp Thr Glu 
    3590                 3595                 3600             


Thr Glu  Ser Ala Val Ala Lys  Ser Leu Glu Lys Leu  Gly Gly Pro 
    3605                 3610                 3615             


Cys Pro  Pro His Phe Leu Lys  Glu Leu Lys Pro Ile  Arg Cys Ala 
    3620                 3625                 3630             


Gln Gly  Leu Pro Ala Ile Phe  Glu Tyr Thr Val Val  Gly Glu Pro 
    3635                 3640                 3645             


Ala Pro  Thr Val Thr Trp Phe  Lys Glu Asn Lys Gln  Leu Cys Thr 
    3650                 3655                 3660             


Ser Val  Tyr Tyr Thr Ile Ile  His Asn Pro Asn Gly  Ser Gly Thr 
    3665                 3670                 3675             


Phe Ile  Val Asn Asp Pro Gln  Arg Glu Asp Ser Gly  Leu Tyr Ile 
    3680                 3685                 3690             


Cys Lys  Ala Glu Asn Met Leu  Gly Glu Ser Thr Cys  Ala Ala Glu 
    3695                 3700                 3705             


Leu Leu  Val Leu Leu Glu Asp  Thr Asp Met Thr Asp  Thr Pro Cys 
    3710                 3715                 3720             


Lys Ala  Lys Ser Thr Pro Glu  Ala Pro Glu Asp Phe  Pro Gln Thr 
    3725                 3730                 3735             


Pro Leu  Lys Gly Pro Ala Val  Glu Ala Leu Asp Ser  Glu Gln Glu 
    3740                 3745                 3750             


Ile Ala  Thr Phe Val Lys Asp  Thr Ile Leu Lys Ala  Ala Leu Ile 
    3755                 3760                 3765             


Thr Glu  Glu Asn Gln Gln Leu  Ser Tyr Glu His Ile  Ala Lys Ala 
    3770                 3775                 3780             


Asn Glu  Leu Ser Ser Gln Leu  Pro Leu Gly Ala Gln  Glu Leu Gln 
    3785                 3790                 3795             


Ser Ile  Leu Glu Gln Asp Lys  Leu Thr Pro Glu Ser  Thr Arg Glu 
    3800                 3805                 3810             


Phe Leu  Cys Ile Asn Gly Ser  Ile His Phe Gln Pro  Leu Lys Glu 
    3815                 3820                 3825             


Pro Ser  Pro Asn Leu Gln Leu  Gln Ile Val Gln Ser  Gln Lys Thr 
    3830                 3835                 3840             


Phe Ser  Lys Glu Gly Ile Leu  Met Pro Glu Glu Pro  Glu Thr Gln 
    3845                 3850                 3855             


Ala Val  Leu Ser Asp Thr Glu  Lys Ile Phe Pro Ser  Ala Met Ser 
    3860                 3865                 3870             


Ile Glu  Gln Ile Asn Ser Leu  Thr Val Glu Pro Leu  Lys Thr Leu 
    3875                 3880                 3885             


Leu Ala  Glu Pro Glu Gly Asn  Tyr Pro Gln Ser Ser  Ile Glu Pro 
    3890                 3895                 3900             


Pro Met  His Ser Tyr Leu Thr  Ser Val Ala Glu Glu  Val Leu Ser 
    3905                 3910                 3915             


Pro Lys  Glu Lys Thr Val Ser  Asp Thr Asn Arg Glu  Gln Arg Val 
    3920                 3925                 3930             


Thr Leu  Gln Lys Gln Glu Ala  Gln Ser Ala Leu Ile  Leu Ser Gln 
    3935                 3940                 3945             


Ser Leu  Ala Glu Gly His Val  Glu Ser Leu Gln Ser  Pro Asp Val 
    3950                 3955                 3960             


Met Ile  Ser Gln Val Asn Tyr  Glu Pro Leu Val Pro  Ser Glu His 
    3965                 3970                 3975             


Ser Cys  Thr Glu Gly Gly Lys  Ile Leu Ile Glu Ser  Ala Asn Pro 
    3980                 3985                 3990             


Leu Glu  Asn Ala Gly Gln Asp  Ser Ala Val Arg Ile  Glu Glu Gly 
    3995                 4000                 4005             


Lys Ser  Leu Arg Phe Pro Leu  Ala Leu Glu Glu Lys  Gln Val Leu 
    4010                 4015                 4020             


Leu Lys  Glu Glu His Ser Asp  Asn Val Val Met Pro  Pro Asp Gln 
    4025                 4030                 4035             


Ile Ile  Glu Ser Lys Arg Glu  Pro Val Ala Ile Lys  Lys Val Gln 
    4040                 4045                 4050             


Glu Val  Gln Gly Arg Asp Leu  Leu Ser Lys Glu Ser  Leu Leu Ser 
    4055                 4060                 4065             


Gly Ile  Pro Glu Glu Gln Arg  Leu Asn Leu Lys Ile  Gln Ile Cys 
    4070                 4075                 4080             


Arg Ala  Leu Gln Ala Ala Val  Ala Ser Glu Gln Pro  Gly Leu Phe 
    4085                 4090                 4095             


Ser Glu  Trp Leu Arg Asn Ile  Glu Lys Val Glu Val  Glu Ala Val 
    4100                 4105                 4110             


Asn Ile  Thr Gln Glu Pro Arg  His Ile Met Cys Met  Tyr Leu Val 
    4115                 4120                 4125             


Thr Ser  Ala Lys Ser Val Thr  Glu Glu Val Thr Ile  Ile Ile Glu 
    4130                 4135                 4140             


Asp Val  Asp Pro Gln Met Ala  Asn Leu Lys Met Glu  Leu Arg Asp 
    4145                 4150                 4155             


Ala Leu  Cys Ala Ile Ile Tyr  Glu Glu Ile Asp Ile  Leu Thr Ala 
    4160                 4165                 4170             


Glu Gly  Pro Arg Ile Gln Gln  Gly Ala Lys Thr Ser  Leu Gln Glu 
    4175                 4180                 4185             


Glu Met  Asp Ser Phe Ser Gly  Ser Gln Lys Val Glu  Pro Ile Thr 
    4190                 4195                 4200             


Glu Pro  Glu Val Glu Ser Lys  Tyr Leu Ile Ser Thr  Glu Glu Val 
    4205                 4210                 4215             


Ser Tyr  Phe Asn Val Gln Ser  Arg Val Lys Tyr Leu  Asp Ala Thr 
    4220                 4225                 4230             


Pro Val  Thr Lys Gly Val Ala  Ser Ala Val Val Ser  Asp Glu Lys 
    4235                 4240                 4245             


Gln Asp  Glu Ser Leu Lys Pro  Ser Glu Glu Lys Glu  Glu Ser Ser 
    4250                 4255                 4260             


Ser Glu  Ser Gly Thr Glu Glu  Val Ala Thr Val Lys  Ile Gln Glu 
    4265                 4270                 4275             


Ala Glu  Gly Gly Leu Ile Lys  Glu Asp Gly Pro Met  Ile His Thr 
    4280                 4285                 4290             


Pro Leu  Val Asp Thr Val Ser  Glu Glu Gly Asp Ile  Val His Leu 
    4295                 4300                 4305             


Thr Thr  Ser Ile Thr Asn Ala  Lys Glu Val Asn Trp  Tyr Phe Glu 
    4310                 4315                 4320             


Asn Lys  Leu Val Pro Ser Asp  Glu Lys Phe Lys Cys  Leu Gln Asp 
    4325                 4330                 4335             


Gln Asn  Thr Tyr Thr Leu Val  Ile Asp Lys Val Asn  Thr Glu Asp 
    4340                 4345                 4350             


His Gln  Gly Glu Tyr Val Cys  Glu Ala Leu Asn Asp  Ser Gly Lys 
    4355                 4360                 4365             


Thr Ala  Thr Ser Ala Lys Leu  Thr Val Val Lys Arg  Ala Ala Pro 
    4370                 4375                 4380             


Val Ile  Lys Arg Lys Ile Glu  Pro Leu Glu Val Ala  Leu Gly His 
    4385                 4390                 4395             


Leu Ala  Lys Phe Thr Cys Glu  Ile Gln Ser Ala Pro  Asn Val Arg 
    4400                 4405                 4410             


Phe Gln  Trp Phe Lys Ala Gly  Arg Glu Ile Tyr Glu  Ser Asp Lys 
    4415                 4420                 4425             


Cys Ser  Ile Arg Ser Ser Lys  Tyr Ile Ser Ser Leu  Glu Ile Leu 
    4430                 4435                 4440             


Arg Thr  Gln Val Val Asp Cys  Gly Glu Tyr Thr Cys  Lys Ala Ser 
    4445                 4450                 4455             


Asn Glu  Tyr Gly Ser Val Ser  Cys Thr Ala Thr Leu  Thr Val Thr 
    4460                 4465                 4470             


Glu Ala  Tyr Pro Pro Thr Phe  Leu Ser Arg Pro Lys  Ser Leu Thr 
    4475                 4480                 4485             


Thr Phe  Val Gly Lys Ala Ala  Lys Phe Ile Cys Thr  Val Thr Gly 
    4490                 4495                 4500             


Thr Pro  Val Ile Glu Thr Ile  Trp Gln Lys Asp Gly  Ala Ala Leu 
    4505                 4510                 4515             


Ser Pro  Ser Pro Asn Trp Arg  Ile Ser Asp Ala Glu  Asn Lys His 
    4520                 4525                 4530             


Ile Leu  Glu Leu Ser Asn Leu  Thr Ile Gln Asp Arg  Gly Val Tyr 
    4535                 4540                 4545             


Ser Cys  Lys Ala Ser Asn Lys  Phe Gly Ala Asp Ile  Cys Gln Ala 
    4550                 4555                 4560             


Glu Leu  Ile Ile Ile Asp Lys  Pro His Phe Ile Lys  Glu Leu Glu 
    4565                 4570                 4575             


Pro Val  Gln Ser Ala Ile Asn  Lys Lys Val His Leu  Glu Cys Gln 
    4580                 4585                 4590             


Val Asp  Glu Asp Arg Lys Val  Thr Val Thr Trp Ser  Lys Asp Gly 
    4595                 4600                 4605             


Gln Lys  Leu Pro Pro Gly Lys  Asp Tyr Lys Ile Cys  Phe Glu Asp 
    4610                 4615                 4620             


Lys Ile  Ala Thr Leu Glu Ile  Pro Leu Ala Lys Leu  Lys Asp Ser 
    4625                 4630                 4635             


Gly Thr  Tyr Val Cys Thr Ala  Ser Asn Glu Ala Gly  Ser Ser Ser 
    4640                 4645                 4650             


Cys Ser  Ala Thr Val Thr Val  Arg Glu Pro Pro Ser  Phe Val Lys 
    4655                 4660                 4665             


Lys Val  Asp Pro Ser Tyr Leu  Met Leu Pro Gly Glu  Ser Ala Arg 
    4670                 4675                 4680             


Leu His  Cys Lys Leu Lys Gly  Ser Pro Val Ile Gln  Val Thr Trp 
    4685                 4690                 4695             


Phe Lys  Asn Asn Lys Glu Leu  Ser Glu Ser Asn Thr  Val Arg Met 
    4700                 4705                 4710             


Tyr Phe  Val Asn Ser Glu Ala  Ile Leu Asp Ile Thr  Asp Val Lys 
    4715                 4720                 4725             


Val Glu  Asp Ser Gly Ser Tyr  Ser Cys Glu Ala Val  Asn Asp Val 
    4730                 4735                 4740             


Gly Ser  Asp Ser Cys Ser Thr  Glu Ile Val Ile Lys  Glu Pro Pro 
    4745                 4750                 4755             


Ser Phe  Ile Lys Thr Leu Glu  Pro Ala Asp Ile Val  Arg Gly Thr 
    4760                 4765                 4770             


Asn Ala  Leu Leu Gln Cys Glu  Val Ser Gly Thr Gly  Pro Phe Glu 
    4775                 4780                 4785             


Ile Ser  Trp Phe Lys Asp Lys  Lys Gln Ile Arg Ser  Ser Lys Lys 
    4790                 4795                 4800             


Tyr Arg  Leu Phe Ser Gln Lys  Ser Leu Val Cys Leu  Glu Ile Phe 
    4805                 4810                 4815             


Ser Phe  Asn Ser Ala Asp Val  Gly Glu Tyr Glu Cys  Val Val Ala 
    4820                 4825                 4830             


Asn Glu  Val Gly Lys Cys Gly  Cys Met Ala Thr His  Leu Leu Lys 
    4835                 4840                 4845             


Glu Pro  Pro Thr Phe Val Lys  Lys Val Asp Asp Leu  Ile Ala Leu 
    4850                 4855                 4860             


Gly Gly  Gln Thr Val Thr Leu  Gln Ala Ala Val Arg  Gly Ser Glu 
    4865                 4870                 4875             


Pro Ile  Ser Val Thr Trp Met  Lys Gly Gln Glu Val  Ile Arg Glu 
    4880                 4885                 4890             


Asp Gly  Lys Ile Lys Met Ser  Phe Ser Asn Gly Val  Ala Val Leu 
    4895                 4900                 4905             


Ile Ile  Pro Asp Val Gln Ile  Ser Phe Gly Gly Lys  Tyr Thr Cys 
    4910                 4915                 4920             


Leu Ala  Glu Asn Glu Ala Gly  Ser Gln Thr Ser Val  Gly Glu Leu 
    4925                 4930                 4935             


Ile Val  Lys Glu Pro Ala Lys  Ile Ile Glu Arg Ala  Glu Leu Ile 
    4940                 4945                 4950             


Gln Val  Thr Ala Gly Asp Pro  Ala Thr Leu Glu Tyr  Thr Val Ala 
    4955                 4960                 4965             


Gly Thr  Pro Glu Leu Lys Pro  Lys Trp Tyr Lys Asp  Gly Arg Pro 
    4970                 4975                 4980             


Leu Val  Ala Ser Lys Lys Tyr  Arg Ile Ser Phe Lys  Asn Asn Val 
    4985                 4990                 4995             


Ala Gln  Leu Lys Phe Tyr Ser  Ala Glu Leu His Asp  Ser Gly Gln 
    5000                 5005                 5010             


Tyr Thr  Phe Glu Ile Ser Asn  Glu Val Gly Ser Ser  Ser Cys Glu 
    5015                 5020                 5025             


Thr Thr  Phe Thr Val Leu Asp  Arg Asp Ile Ala Pro  Phe Phe Thr 
    5030                 5035                 5040             


Lys Pro  Leu Arg Asn Val Asp  Ser Val Val Asn Gly  Thr Cys Arg 
    5045                 5050                 5055             


Leu Asp  Cys Lys Ile Ala Gly  Ser Leu Pro Met Arg  Val Ser Trp 
    5060                 5065                 5070             


Phe Lys  Asp Gly Lys Glu Ile  Ala Ala Ser Asp Arg  Tyr Arg Ile 
    5075                 5080                 5085             


Ala Phe  Val Glu Gly Thr Ala  Ser Leu Glu Ile Ile  Arg Val Asp 
    5090                 5095                 5100             


Met Asn  Asp Ala Gly Asn Phe  Thr Cys Arg Ala Thr  Asn Ser Val 
    5105                 5110                 5115             


Gly Ser  Lys Asp Ser Ser Gly  Ala Leu Ile Val Gln  Glu Pro Pro 
    5120                 5125                 5130             


Ser Phe  Val Thr Lys Pro Gly  Ser Lys Asp Val Leu  Pro Gly Ser 
    5135                 5140                 5145             


Ala Val  Cys Leu Lys Ser Thr  Phe Gln Gly Ser Thr  Pro Leu Thr 
    5150                 5155                 5160             


Ile Arg  Trp Phe Lys Gly Asn  Lys Glu Leu Val Ser  Gly Gly Ser 
    5165                 5170                 5175             


Cys Tyr  Ile Thr Lys Glu Ala  Leu Glu Ser Ser Leu  Glu Leu Tyr 
    5180                 5185                 5190             


Leu Val  Lys Thr Ser Asp Ser  Gly Thr Tyr Thr Cys  Lys Val Ser 
    5195                 5200                 5205             


Asn Val  Ala Gly Gly Val Glu  Cys Ser Ala Asn Leu  Phe Val Lys 
    5210                 5215                 5220             


Glu Pro  Ala Thr Phe Val Glu  Lys Leu Glu Pro Ser  Gln Leu Leu 
    5225                 5230                 5235             


Lys Lys  Gly Asp Ala Thr Gln  Leu Ala Cys Lys Val  Thr Gly Thr 
    5240                 5245                 5250             


Pro Pro  Ile Lys Ile Thr Trp  Phe Ala Asn Asp Arg  Glu Ile Lys 
    5255                 5260                 5265             


Glu Ser  Ser Lys His Arg Met  Ser Phe Val Glu Ser  Thr Ala Val 
    5270                 5275                 5280             


Leu Arg  Leu Thr Asp Val Gly  Ile Glu Asp Ser Gly  Glu Tyr Met 
    5285                 5290                 5295             


Cys Glu  Ala Gln Asn Glu Ala  Gly Ser Asp His Cys  Ser Ser Ile 
    5300                 5305                 5310             


Val Ile  Val Lys Glu Ser Pro  Tyr Phe Thr Lys Glu  Phe Lys Pro 
    5315                 5320                 5325             


Ile Glu  Val Leu Lys Glu Tyr  Asp Val Met Leu Leu  Ala Glu Val 
    5330                 5335                 5340             


Ala Gly  Thr Pro Pro Phe Glu  Ile Thr Trp Phe Lys  Asp Asn Thr 
    5345                 5350                 5355             


Ile Leu  Arg Ser Gly Arg Lys  Tyr Lys Thr Phe Ile  Gln Asp His 
    5360                 5365                 5370             


Leu Val  Ser Leu Gln Ile Leu  Lys Phe Val Ala Ala  Asp Ala Gly 
    5375                 5380                 5385             


Glu Tyr  Gln Cys Arg Val Thr  Asn Glu Val Gly Ser  Ser Ile Cys 
    5390                 5395                 5400             


Ser Ala  Arg Val Thr Leu Arg  Glu Pro Pro Ser Phe  Ile Lys Lys 
    5405                 5410                 5415             


Ile Glu  Ser Thr Ser Ser Leu  Arg Gly Gly Thr Ala  Ala Phe Gln 
    5420                 5425                 5430             


Ala Thr  Leu Lys Gly Ser Leu  Pro Ile Thr Val Thr  Trp Leu Lys 
    5435                 5440                 5445             


Asp Ser  Asp Glu Ile Thr Glu  Asp Asp Asn Ile Arg  Met Thr Phe 
    5450                 5455                 5460             


Glu Asn  Asn Val Ala Ser Leu  Tyr Leu Ser Gly Ile  Glu Val Lys 
    5465                 5470                 5475             


His Asp  Gly Lys Tyr Val Cys  Gln Ala Lys Asn Asp  Ala Gly Ile 
    5480                 5485                 5490             


Gln Arg  Cys Ser Ala Leu Leu  Ser Val Lys Glu Pro  Ala Thr Ile 
    5495                 5500                 5505             


Thr Glu  Glu Ala Val Ser Ile  Asp Val Thr Gln Gly  Asp Pro Ala 
    5510                 5515                 5520             


Thr Leu  Gln Val Lys Phe Ser  Gly Thr Lys Glu Ile  Thr Ala Lys 
    5525                 5530                 5535             


Trp Phe  Lys Asp Gly Gln Glu  Leu Thr Leu Gly Ser  Lys Tyr Lys 
    5540                 5545                 5550             


Ile Ser  Val Thr Asp Thr Val  Ser Ile Leu Lys Ile  Ile Ser Thr 
    5555                 5560                 5565             


Glu Lys  Lys Asp Ser Gly Glu  Tyr Thr Phe Glu Val  Gln Asn Asp 
    5570                 5575                 5580             


Val Gly  Arg Ser Ser Cys Lys  Ala Arg Ile Asn Val  Leu Asp Leu 
    5585                 5590                 5595             


Ile Ile  Pro Pro Ser Phe Thr  Lys Lys Leu Lys Lys  Met Asp Ser 
    5600                 5605                 5610             


Ile Lys  Gly Ser Phe Ile Asp  Leu Glu Cys Ile Val  Ala Gly Ser 
    5615                 5620                 5625             


His Pro  Ile Ser Ile Gln Trp  Phe Lys Asp Asp Gln  Glu Ile Ser 
    5630                 5635                 5640             


Ala Ser  Glu Lys Tyr Lys Phe  Ser Phe His Asp Asn  Thr Ala Phe 
    5645                 5650                 5655             


Leu Glu  Ile Ser Gln Leu Glu  Gly Thr Asp Ser Gly  Thr Tyr Thr 
    5660                 5665                 5670             


Cys Ser  Ala Thr Asn Lys Ala  Gly His Asn Gln Cys  Ser Gly His 
    5675                 5680                 5685             


Leu Thr  Val Lys Glu Pro Pro  Tyr Phe Val Glu Lys  Pro Gln Ser 
    5690                 5695                 5700             


Gln Asp  Val Asn Pro Asn Thr  Arg Val Gln Leu Lys  Ala Leu Val 
    5705                 5710                 5715             


Gly Gly  Thr Ala Pro Met Thr  Ile Lys Trp Phe Lys  Asp Asn Lys 
    5720                 5725                 5730             


Glu Leu  His Ser Gly Ala Ala  Arg Ser Val Trp Lys  Asp Asp Thr 
    5735                 5740                 5745             


Ser Thr  Ser Leu Glu Leu Phe  Ala Ala Lys Ala Thr  Asp Ser Gly 
    5750                 5755                 5760             


Thr Tyr  Ile Cys Gln Leu Ser  Asn Asp Val Gly Thr  Ala Thr Ser 
    5765                 5770                 5775             


Lys Ala  Thr Leu Phe Val Lys  Glu Pro Pro Gln Phe  Ile Lys Lys 
    5780                 5785                 5790             


Pro Ser  Pro Val Leu Val Leu  Arg Asn Gly Gln Ser  Thr Thr Phe 
    5795                 5800                 5805             


Glu Cys  Gln Ile Thr Gly Thr  Pro Lys Ile Arg Val  Ser Trp Tyr 
    5810                 5815                 5820             


Leu Asp  Gly Asn Glu Ile Thr  Ala Ile Gln Lys His  Gly Ile Ser 
    5825                 5830                 5835             


Phe Ile  Asp Gly Leu Ala Thr  Phe Gln Ile Ser Gly  Ala Arg Val 
    5840                 5845                 5850             


Glu Asn  Ser Gly Thr Tyr Val  Cys Glu Ala Arg Asn  Asp Ala Gly 
    5855                 5860                 5865             


Thr Ala  Ser Cys Ser Ile Glu  Leu Lys Val Lys Glu  Pro Pro Thr 
    5870                 5875                 5880             


Phe Ile  Arg Glu Leu Lys Pro  Val Glu Val Val Lys  Tyr Ser Asp 
    5885                 5890                 5895             


Val Glu  Leu Glu Cys Glu Val  Thr Gly Thr Pro Pro  Phe Glu Val 
    5900                 5905                 5910             


Thr Trp  Leu Lys Asn Asn Arg  Glu Ile Arg Ser Ser  Lys Lys Tyr 
    5915                 5920                 5925             


Thr Leu  Thr Asp Arg Val Ser  Val Phe Asn Leu His  Ile Thr Lys 
    5930                 5935                 5940             


Cys Asp  Pro Ser Asp Thr Gly  Glu Tyr Gln Cys Ile  Val Ser Asn 
    5945                 5950                 5955             


Glu Gly  Gly Ser Cys Ser Cys  Ser Thr Arg Val Ala  Leu Lys Glu 
    5960                 5965                 5970             


Pro Pro  Ser Phe Ile Lys Lys  Ile Glu Asn Thr Thr  Thr Val Leu 
    5975                 5980                 5985             


Lys Ser  Ser Ala Thr Phe Gln  Ser Thr Val Ala Gly  Ser Pro Pro 
    5990                 5995                 6000             


Ile Ser  Ile Thr Trp Leu Lys  Asp Asp Gln Ile Leu  Asp Glu Asp 
    6005                 6010                 6015             


Asp Asn  Val Tyr Ile Ser Phe  Val Asp Ser Val Ala  Thr Leu Gln 
    6020                 6025                 6030             


Ile Arg  Ser Val Asp Asn Gly  His Ser Gly Arg Tyr  Thr Cys Gln 
    6035                 6040                 6045             


Ala Lys  Asn Glu Ser Gly Val  Glu Arg Cys Tyr Ala  Phe Leu Leu 
    6050                 6055                 6060             


Val Gln  Glu Pro Ala Gln Ile  Val Glu Lys Ala Lys  Ser Val Asp 
    6065                 6070                 6075             


Val Thr  Glu Lys Asp Pro Met  Thr Leu Glu Cys Val  Val Ala Gly 
    6080                 6085                 6090             


Thr Pro  Glu Leu Lys Val Lys  Trp Leu Lys Asp Gly  Lys Gln Ile 
    6095                 6100                 6105             


Val Pro  Ser Arg Tyr Phe Ser  Met Ser Phe Glu Asn  Asn Val Ala 
    6110                 6115                 6120             


Ser Phe  Arg Ile Gln Ser Val  Met Lys Gln Asp Ser  Gly Gln Tyr 
    6125                 6130                 6135             


Thr Phe  Lys Val Glu Asn Asp  Phe Gly Ser Ser Ser  Cys Asp Ala 
    6140                 6145                 6150             


Tyr Leu  Arg Val Leu Asp Gln  Asn Ile Pro Pro Ser  Phe Thr Lys 
    6155                 6160                 6165             


Lys Leu  Thr Lys Met Asp Lys  Val Leu Gly Ser Ser  Ile His Met 
    6170                 6175                 6180             


Glu Cys  Lys Val Ser Gly Ser  Leu Pro Ile Ser Ala  Gln Trp Phe 
    6185                 6190                 6195             


Lys Asp  Gly Lys Glu Ile Ser  Thr Ser Ala Lys Tyr  Arg Leu Val 
    6200                 6205                 6210             


Cys His  Glu Arg Ser Val Ser  Leu Glu Val Asn Asn  Leu Glu Leu 
    6215                 6220                 6225             


Glu Asp  Thr Ala Asn Tyr Thr  Cys Lys Val Ser Asn  Val Ala Gly 
    6230                 6235                 6240             


Asp Asp  Ala Cys Ser Gly Ile  Leu Thr Val Lys Glu  Pro Pro Ser 
    6245                 6250                 6255             


Phe Leu  Val Lys Pro Gly Arg  Gln Gln Ala Ile Pro  Asp Ser Thr 
    6260                 6265                 6270             


Val Glu  Phe Lys Ala Ile Leu  Lys Gly Thr Pro Pro  Phe Lys Ile 
    6275                 6280                 6285             


Lys Trp  Phe Lys Asp Asp Val  Glu Leu Val Ser Gly  Pro Lys Cys 
    6290                 6295                 6300             


Phe Ile  Gly Leu Glu Gly Ser  Thr Ser Phe Leu Asn  Leu Tyr Ser 
    6305                 6310                 6315             


Val Asp  Ala Ser Lys Thr Gly  Gln Tyr Thr Cys His  Val Thr Asn 
    6320                 6325                 6330             


Asp Val  Gly Ser Asp Ser Cys  Thr Thr Met Leu Leu  Val Thr Glu 
    6335                 6340                 6345             


Pro Pro  Lys Phe Val Lys Lys  Leu Glu Ala Ser Lys  Ile Val Lys 
    6350                 6355                 6360             


Ala Gly  Asp Ser Ser Arg Leu  Glu Cys Lys Ile Ala  Gly Ser Pro 
    6365                 6370                 6375             


Glu Ile  Arg Val Val Trp Phe  Arg Asn Glu His Glu  Leu Pro Ala 
    6380                 6385                 6390             


Ser Asp  Lys Tyr Arg Met Thr  Phe Ile Asp Ser Val  Ala Val Ile 
    6395                 6400                 6405             


Gln Met  Asn Asn Leu Ser Thr  Glu Asp Ser Gly Asp  Phe Ile Cys 
    6410                 6415                 6420             


Glu Ala  Gln Asn Pro Ala Gly  Ser Thr Ser Cys Ser  Thr Lys Val 
    6425                 6430                 6435             


Ile Val  Lys Glu Pro Pro Val  Phe Ser Ser Phe Pro  Pro Ile Val 
    6440                 6445                 6450             


Glu Thr  Leu Lys Asn Ala Glu  Val Ser Leu Glu Cys  Glu Leu Ser 
    6455                 6460                 6465             


Gly Thr  Pro Pro Phe Glu Val  Val Trp Tyr Lys Asp  Lys Arg Gln 
    6470                 6475                 6480             


Leu Arg  Ser Ser Lys Lys Tyr  Lys Ile Ala Ser Lys  Asn Phe His 
    6485                 6490                 6495             


Thr Ser  Ile His Ile Leu Asn  Val Asp Thr Ser Asp  Ile Gly Glu 
    6500                 6505                 6510             


Tyr His  Cys Lys Ala Gln Asn  Glu Val Gly Ser Asp  Thr Cys Val 
    6515                 6520                 6525             


Cys Thr  Val Lys Leu Lys Glu  Pro Pro Arg Phe Val  Ser Lys Leu 
    6530                 6535                 6540             


Asn Ser  Leu Thr Val Val Ala  Gly Glu Pro Ala Glu  Leu Gln Ala 
    6545                 6550                 6555             


Ser Ile  Glu Gly Ala Gln Pro  Ile Phe Val Gln Trp  Leu Lys Glu 
    6560                 6565                 6570             


Lys Glu  Glu Val Ile Arg Glu  Ser Glu Asn Ile Arg  Ile Thr Phe 
    6575                 6580                 6585             


Val Glu  Asn Val Ala Thr Leu  Gln Phe Ala Lys Ala  Glu Pro Ala 
    6590                 6595                 6600             


Asn Ala  Gly Lys Tyr Ile Cys  Gln Ile Lys Asn Asp  Gly Gly Met 
    6605                 6610                 6615             


Glu Glu  Asn Met Ala Thr Leu  Met Val Leu Glu Pro  Ala Val Ile 
    6620                 6625                 6630             


Val Glu  Lys Ala Gly Pro Met  Thr Val Thr Val Gly  Glu Thr Cys 
    6635                 6640                 6645             


Thr Leu  Glu Cys Lys Val Ala  Gly Thr Pro Glu Leu  Ser Val Glu 
    6650                 6655                 6660             


Trp Tyr  Lys Asp Gly Lys Leu  Leu Thr Ser Ser Gln  Lys His Lys 
    6665                 6670                 6675             


Phe Ser  Phe Tyr Asn Lys Ile  Ser Ser Leu Arg Ile  Leu Ser Val 
    6680                 6685                 6690             


Glu Arg  Gln Asp Ala Gly Thr  Tyr Thr Phe Gln Val  Gln Asn Asn 
    6695                 6700                 6705             


Val Gly  Lys Ser Ser Cys Thr  Ala Val Val Asp Val  Ser Asp Arg 
    6710                 6715                 6720             


Ala Val  Pro Pro Ser Phe Thr  Arg Arg Leu Lys Asn  Thr Gly Gly 
    6725                 6730                 6735             


Val Leu  Gly Ala Ser Cys Ile  Leu Glu Cys Lys Val  Ala Gly Ser 
    6740                 6745                 6750             


Ser Pro  Ile Ser Val Ala Trp  Phe His Glu Lys Thr  Lys Ile Val 
    6755                 6760                 6765             


Ser Gly  Ala Lys Tyr Gln Thr  Thr Phe Ser Asp Asn  Val Cys Thr 
    6770                 6775                 6780             


Leu Gln  Leu Asn Ser Leu Asp  Ser Ser Asp Met Gly  Asn Tyr Thr 
    6785                 6790                 6795             


Cys Val  Ala Ala Asn Val Ala  Gly Ser Asp Glu Cys  Arg Ala Val 
    6800                 6805                 6810             


Leu Thr  Val Gln Glu Pro Pro  Ser Phe Val Lys Glu  Pro Glu Pro 
    6815                 6820                 6825             


Leu Glu  Val Leu Pro Gly Lys  Asn Val Thr Phe Thr  Ser Val Ile 
    6830                 6835                 6840             


Arg Gly  Thr Pro Pro Phe Lys  Val Asn Trp Phe Arg  Gly Ala Arg 
    6845                 6850                 6855             


Glu Leu  Val Lys Gly Asp Arg  Cys Asn Ile Tyr Phe  Glu Asp Thr 
    6860                 6865                 6870             


Val Ala  Glu Leu Glu Leu Phe  Asn Ile Asp Ile Ser  Gln Ser Gly 
    6875                 6880                 6885             


Glu Tyr  Thr Cys Val Val Ser  Asn Asn Ala Gly Gln  Ala Ser Cys 
    6890                 6895                 6900             


Thr Thr  Arg Leu Phe Val Lys  Glu Pro Ala Ala Phe  Leu Lys Arg 
    6905                 6910                 6915             


Leu Ser  Asp His Ser Val Glu  Pro Gly Lys Ser Ile  Ile Leu Glu 
    6920                 6925                 6930             


Ser Thr  Tyr Thr Gly Thr Leu  Pro Ile Ser Val Thr  Trp Lys Lys 
    6935                 6940                 6945             


Asp Gly  Phe Asn Ile Thr Thr  Ser Glu Lys Cys Asn  Ile Val Thr 
    6950                 6955                 6960             


Thr Glu  Lys Thr Cys Ile Leu  Glu Ile Leu Asn Ser  Thr Lys Arg 
    6965                 6970                 6975             


Asp Ala  Gly Gln Tyr Ser Cys  Glu Ile Glu Asn Glu  Ala Gly Arg 
    6980                 6985                 6990             


Asp Val  Cys Gly Ala Leu Val  Ser Thr Leu Glu Pro  Pro Tyr Phe 
    6995                 7000                 7005             


Val Thr  Glu Leu Glu Pro Leu  Glu Ala Ala Val Gly  Asp Ser Val 
    7010                 7015                 7020             


Ser Leu  Gln Cys Gln Val Ala  Gly Thr Pro Glu Ile  Thr Val Ser 
    7025                 7030                 7035             


Trp Tyr  Lys Gly Asp Thr Lys  Leu Arg Pro Thr Pro  Glu Tyr Arg 
    7040                 7045                 7050             


Thr Tyr  Phe Thr Asn Asn Val  Ala Thr Leu Val Phe  Asn Lys Val 
    7055                 7060                 7065             


Asn Ile  Asn Asp Ser Gly Glu  Tyr Thr Cys Lys Ala  Glu Asn Ser 
    7070                 7075                 7080             


Ile Gly  Thr Ala Ser Ser Lys  Thr Val Phe Arg Ile  Gln Glu Arg 
    7085                 7090                 7095             


Gln Leu  Pro Pro Ser Phe Ala  Arg Gln Leu Lys Asp  Ile Glu Gln 
    7100                 7105                 7110             


Thr Val  Gly Leu Pro Val Thr  Leu Thr Cys Arg Leu  Asn Gly Ser 
    7115                 7120                 7125             


Ala Pro  Ile Gln Val Cys Trp  Tyr Arg Asp Gly Val  Leu Leu Arg 
    7130                 7135                 7140             


Asp Asp  Glu Asn Leu Gln Thr  Ser Phe Val Asp Asn  Val Ala Thr 
    7145                 7150                 7155             


Leu Lys  Ile Leu Gln Thr Asp  Leu Ser His Ser Gly  Gln Tyr Ser 
    7160                 7165                 7170             


Cys Ser  Ala Ser Asn Pro Leu  Gly Thr Ala Ser Ser  Ser Ala Arg 
    7175                 7180                 7185             


Leu Thr  Ala Arg Glu Pro Lys  Lys Ser Pro Phe Phe  Asp Ile Lys 
    7190                 7195                 7200             


Pro Val  Ser Ile Asp Val Ile  Ala Gly Glu Ser Ala  Asp Phe Glu 
    7205                 7210                 7215             


Cys His  Val Thr Gly Ala Gln  Pro Met Arg Ile Thr  Trp Ser Lys 
    7220                 7225                 7230             


Asp Asn  Lys Glu Ile Arg Pro  Gly Gly Asn Tyr Thr  Ile Thr Cys 
    7235                 7240                 7245             


Val Gly  Asn Thr Pro His Leu  Arg Ile Leu Lys Val  Gly Lys Gly 
    7250                 7255                 7260             


Asp Ser  Gly Gln Tyr Thr Cys  Gln Ala Thr Asn Asp  Val Gly Lys 
    7265                 7270                 7275             


Asp Met  Cys Ser Ala Gln Leu  Ser Val Lys Glu Pro  Pro Lys Phe 
    7280                 7285                 7290             


Val Lys  Lys Leu Glu Ala Ser  Lys Val Ala Lys Gln  Gly Glu Ser 
    7295                 7300                 7305             


Ile Gln  Leu Glu Cys Lys Ile  Ser Gly Ser Pro Glu  Ile Lys Val 
    7310                 7315                 7320             


Ser Trp  Phe Arg Asn Asp Ser  Glu Leu His Glu Ser  Trp Lys Tyr 
    7325                 7330                 7335             


Asn Met  Ser Phe Ile Asn Ser  Val Ala Leu Leu Thr  Ile Asn Glu 
    7340                 7345                 7350             


Ala Ser  Ala Glu Asp Ser Gly  Asp Tyr Ile Cys Glu  Ala His Asn 
    7355                 7360                 7365             


Gly Val  Gly Asp Ala Ser Cys  Ser Thr Ala Leu Thr  Val Lys Ala 
    7370                 7375                 7380             


Pro Pro  Val Phe Thr Gln Lys  Pro Ser Pro Val Gly  Ala Leu Lys 
    7385                 7390                 7395             


Gly Ser  Asp Val Ile Leu Gln  Cys Glu Ile Ser Gly  Thr Pro Pro 
    7400                 7405                 7410             


Phe Glu  Val Val Trp Val Lys  Asp Arg Lys Gln Val  Arg Asn Ser 
    7415                 7420                 7425             


Lys Lys  Phe Lys Ile Thr Ser  Lys His Phe Asp Thr  Ser Leu His 
    7430                 7435                 7440             


Ile Leu  Asn Leu Glu Ala Ser  Asp Val Gly Glu Tyr  His Cys Lys 
    7445                 7450                 7455             


Ala Thr  Asn Glu Val Gly Ser  Asp Thr Cys Ser Cys  Ser Val Lys 
    7460                 7465                 7470             


Phe Lys  Glu Pro Pro Arg Phe  Val Lys Lys Leu Ser  Asp Thr Ser 
    7475                 7480                 7485             


Thr Leu  Ile Gly Asp Ala Val  Glu Leu Arg Ala Ile  Val Glu Gly 
    7490                 7495                 7500             


Phe Gln  Pro Ile Ser Val Val  Trp Leu Lys Asp Arg  Gly Glu Val 
    7505                 7510                 7515             


Ile Arg  Glu Ser Glu Asn Thr  Arg Ile Ser Phe Ile  Asp Asn Ile 
    7520                 7525                 7530             


Ala Thr  Leu Gln Leu Gly Ser  Pro Glu Ala Ser Asn  Ser Gly Lys 
    7535                 7540                 7545             


Tyr Ile  Cys Gln Ile Lys Asn  Asp Ala Gly Met Arg  Glu Cys Ser 
    7550                 7555                 7560             


Ala Val  Leu Thr Val Leu Glu  Pro Ala Arg Ile Ile  Glu Lys Pro 
    7565                 7570                 7575             


Glu Pro  Met Thr Val Thr Thr  Gly Asn Pro Phe Ala  Leu Glu Cys 
    7580                 7585                 7590             


Val Val  Thr Gly Thr Pro Glu  Leu Ser Ala Lys Trp  Phe Lys Asp 
    7595                 7600                 7605             


Gly Arg  Glu Leu Ser Ala Asp  Ser Lys His His Ile  Thr Phe Ile 
    7610                 7615                 7620             


Asn Lys  Val Ala Ser Leu Lys  Ile Pro Cys Ala Glu  Met Ser Asp 
    7625                 7630                 7635             


Lys Gly  Leu Tyr Ser Phe Glu  Val Lys Asn Ser Val  Gly Lys Ser 
    7640                 7645                 7650             


Asn Cys  Thr Val Ser Val His  Val Ser Asp Arg Ile  Val Pro Pro 
    7655                 7660                 7665             


Ser Phe  Ile Arg Lys Leu Lys  Asp Val Asn Ala Ile  Leu Gly Ala 
    7670                 7675                 7680             


Ser Val  Val Leu Glu Cys Arg  Val Ser Gly Ser Ala  Pro Ile Ser 
    7685                 7690                 7695             


Val Gly  Trp Phe Gln Asp Gly  Asn Glu Ile Val Ser  Gly Pro Lys 
    7700                 7705                 7710             


Cys Gln  Ser Ser Phe Ser Glu  Asn Val Cys Thr Leu  Asn Leu Ser 
    7715                 7720                 7725             


Leu Leu  Glu Pro Ser Asp Thr  Gly Ile Tyr Thr Cys  Val Ala Ala 
    7730                 7735                 7740             


Asn Val  Ala Gly Ser Asp Glu  Cys Ser Ala Val Leu  Thr Val Gln 
    7745                 7750                 7755             


Glu Pro  Pro Ser Phe Glu Gln  Thr Pro Asp Ser Val  Glu Val Leu 
    7760                 7765                 7770             


Pro Gly  Met Ser Leu Thr Phe  Thr Ser Val Ile Arg  Gly Thr Pro 
    7775                 7780                 7785             


Pro Phe  Lys Val Lys Trp Phe  Lys Gly Ser Arg Glu  Leu Val Pro 
    7790                 7795                 7800             


Gly Glu  Ser Cys Asn Ile Ser  Leu Glu Asp Phe Val  Thr Glu Leu 
    7805                 7810                 7815             


Glu Leu  Phe Glu Val Gln Pro  Leu Glu Ser Gly Asp  Tyr Ser Cys 
    7820                 7825                 7830             


Leu Val  Thr Asn Asp Ala Gly  Ser Ala Ser Cys Thr  Thr His Leu 
    7835                 7840                 7845             


Phe Val  Lys Glu Pro Ala Thr  Phe Val Lys Arg Leu  Ala Asp Phe 
    7850                 7855                 7860             


Ser Val  Glu Thr Gly Ser Pro  Ile Val Leu Glu Ala  Thr Tyr Thr 
    7865                 7870                 7875             


Gly Thr  Pro Pro Ile Ser Val  Ser Trp Ile Lys Asp  Glu Tyr Leu 
    7880                 7885                 7890             


Ile Ser  Gln Ser Glu Arg Cys  Ser Ile Thr Met Thr  Glu Lys Ser 
    7895                 7900                 7905             


Thr Ile  Leu Glu Ile Leu Glu  Ser Thr Ile Glu Asp  Tyr Ala Gln 
    7910                 7915                 7920             


Tyr Ser  Cys Leu Ile Glu Asn  Glu Ala Gly Gln Asp  Ile Cys Glu 
    7925                 7930                 7935             


Ala Leu  Val Ser Val Leu Glu  Pro Pro Tyr Phe Ile  Glu Pro Leu 
    7940                 7945                 7950             


Glu His  Val Glu Ala Val Ile  Gly Glu Pro Ala Thr  Leu Gln Cys 
    7955                 7960                 7965             


Lys Val  Asp Gly Thr Pro Glu  Ile Arg Ile Ser Trp  Tyr Lys Glu 
    7970                 7975                 7980             


His Thr  Lys Leu Arg Ser Ala  Pro Ala Tyr Lys Met  Gln Phe Lys 
    7985                 7990                 7995             


Asn Asn  Val Ala Ser Leu Val  Ile Asn Lys Val Asp  His Ser Asp 
    8000                 8005                 8010             


Val Gly  Glu Tyr Ser Cys Lys  Ala Asp Asn Ser Val  Gly Ala Val 
    8015                 8020                 8025             


Ala Ser  Ser Ala Val Leu Val  Ile Lys Glu Arg Lys  Leu Pro Pro 
    8030                 8035                 8040             


Phe Phe  Ala Arg Lys Leu Lys  Asp Val His Glu Thr  Leu Gly Phe 
    8045                 8050                 8055             


Pro Val  Ala Phe Glu Cys Arg  Ile Asn Gly Ser Glu  Pro Leu Gln 
    8060                 8065                 8070             


Val Ser  Trp Tyr Lys Asp Gly  Val Leu Leu Lys Asp  Asp Ala Asn 
    8075                 8080                 8085             


Leu Gln  Thr Ser Phe Val His  Asn Val Ala Thr Leu  Gln Ile Leu 
    8090                 8095                 8100             


Gln Thr  Asp Gln Ser His Ile  Gly Gln Tyr Asn Cys  Ser Ala Ser 
    8105                 8110                 8115             


Asn Pro  Leu Gly Thr Ala Ser  Ser Ser Ala Lys Leu  Ile Leu Ser 
    8120                 8125                 8130             


Glu His  Glu Val Pro Pro Phe  Phe Asp Leu Lys Pro  Val Ser Val 
    8135                 8140                 8145             


Asp Leu  Ala Leu Gly Glu Ser  Gly Thr Phe Lys Cys  His Val Thr 
    8150                 8155                 8160             


Gly Thr  Ala Pro Ile Lys Ile  Thr Trp Ala Lys Asp  Asn Arg Glu 
    8165                 8170                 8175             


Ile Arg  Pro Gly Gly Asn Tyr  Lys Met Thr Leu Val  Glu Asn Thr 
    8180                 8185                 8190             


Ala Thr  Leu Thr Val Leu Lys  Val Gly Lys Gly Asp  Ala Gly Gln 
    8195                 8200                 8205             


Tyr Thr  Cys Tyr Ala Ser Asn  Ile Ala Gly Lys Asp  Ser Cys Ser 
    8210                 8215                 8220             


Ala His  Leu Gly Val Gln Glu  Pro Pro Arg Phe Ile  Lys Lys Leu 
    8225                 8230                 8235             


Glu Pro  Ser Arg Ile Val Lys  Gln Asp Glu Phe Thr  Arg Tyr Glu 
    8240                 8245                 8250             


Cys Lys  Ile Gly Gly Ser Pro  Glu Ile Lys Val Leu  Trp Tyr Lys 
    8255                 8260                 8265             


Asp Glu  Thr Glu Ile Gln Glu  Ser Ser Lys Phe Arg  Met Ser Phe 
    8270                 8275                 8280             


Val Asp  Ser Val Ala Val Leu  Glu Met His Asn Leu  Ser Val Glu 
    8285                 8290                 8295             


Asp Ser  Gly Asp Tyr Thr Cys  Glu Ala His Asn Ala  Ala Gly Ser 
    8300                 8305                 8310             


Ala Ser  Ser Ser Thr Ser Leu  Lys Val Lys Glu Pro  Pro Ile Phe 
    8315                 8320                 8325             


Arg Lys  Lys Pro His Pro Ile  Glu Thr Leu Lys Gly  Ala Asp Val 
    8330                 8335                 8340             


His Leu  Glu Cys Glu Leu Gln  Gly Thr Pro Pro Phe  His Val Ser 
    8345                 8350                 8355             


Trp Tyr  Lys Asp Lys Arg Glu  Leu Arg Ser Gly Lys  Lys Tyr Lys 
    8360                 8365                 8370             


Ile Met  Ser Glu Asn Phe Leu  Thr Ser Ile His Ile  Leu Asn Val 
    8375                 8380                 8385             


Asp Ala  Ala Asp Ile Gly Glu  Tyr Gln Cys Lys Ala  Thr Asn Asp 
    8390                 8395                 8400             


Val Gly  Ser Asp Thr Cys Val  Gly Ser Ile Ala Leu  Lys Ala Pro 
    8405                 8410                 8415             


Pro Arg  Phe Val Lys Lys Leu  Ser Asp Ile Ser Thr  Val Val Gly 
    8420                 8425                 8430             


Lys Glu  Val Gln Leu Gln Thr  Thr Ile Glu Gly Ala  Glu Pro Ile 
    8435                 8440                 8445             


Ser Val  Val Trp Phe Lys Asp  Lys Gly Glu Ile Val  Arg Glu Ser 
    8450                 8455                 8460             


Asp Asn  Ile Trp Ile Ser Tyr  Ser Glu Asn Ile Ala  Thr Leu Gln 
    8465                 8470                 8475             


Phe Ser  Arg Val Glu Pro Ala  Asn Ala Gly Lys Tyr  Thr Cys Gln 
    8480                 8485                 8490             


Ile Lys  Asn Asp Ala Gly Met  Gln Glu Cys Phe Ala  Thr Leu Ser 
    8495                 8500                 8505             


Val Leu  Glu Pro Ala Thr Ile  Val Glu Lys Pro Glu  Ser Ile Lys 
    8510                 8515                 8520             


Val Thr  Thr Gly Asp Thr Cys  Thr Leu Glu Cys Thr  Val Ala Gly 
    8525                 8530                 8535             


Thr Pro  Glu Leu Ser Thr Lys  Trp Phe Lys Asp Gly  Lys Glu Leu 
    8540                 8545                 8550             


Thr Ser  Asp Asn Lys Tyr Lys  Ile Ser Phe Phe Asn  Lys Val Ser 
    8555                 8560                 8565             


Gly Leu  Lys Ile Ile Asn Val  Ala Pro Ser Asp Ser  Gly Val Tyr 
    8570                 8575                 8580             


Ser Phe  Glu Val Gln Asn Pro  Val Gly Lys Asp Ser  Cys Thr Ala 
    8585                 8590                 8595             


Ser Leu  Gln Val Ser Asp Arg  Thr Val Pro Pro Ser  Phe Thr Arg 
    8600                 8605                 8610             


Lys Leu  Lys Glu Thr Asn Gly  Leu Ser Gly Ser Ser  Val Val Met 
    8615                 8620                 8625             


Glu Cys  Lys Val Tyr Gly Ser  Pro Pro Ile Ser Val  Ser Trp Phe 
    8630                 8635                 8640             


His Glu  Gly Asn Glu Ile Ser  Ser Gly Arg Lys Tyr  Gln Thr Thr 
    8645                 8650                 8655             


Leu Thr  Asp Asn Thr Cys Ala  Leu Thr Val Asn Met  Leu Glu Glu 
    8660                 8665                 8670             


Ser Asp  Ser Gly Asp Tyr Thr  Cys Ile Ala Thr Asn  Met Ala Gly 
    8675                 8680                 8685             


Ser Asp  Glu Cys Ser Ala Pro  Leu Thr Val Arg Glu  Pro Pro Ser 
    8690                 8695                 8700             


Phe Val  Gln Lys Pro Asp Pro  Met Asp Val Leu Thr  Gly Thr Asn 
    8705                 8710                 8715             


Val Thr  Phe Thr Ser Ile Val  Lys Gly Thr Pro Pro  Phe Ser Val 
    8720                 8725                 8730             


Ser Trp  Phe Lys Gly Ser Ser  Glu Leu Val Pro Gly  Asp Arg Cys 
    8735                 8740                 8745             


Asn Val  Ser Leu Glu Asp Ser  Val Ala Glu Leu Glu  Leu Phe Asp 
    8750                 8755                 8760             


Val Asp  Thr Ser Gln Ser Gly  Glu Tyr Thr Cys Ile  Val Ser Asn 
    8765                 8770                 8775             


Glu Ala  Gly Lys Ala Ser Cys  Thr Thr His Leu Tyr  Ile Lys Ala 
    8780                 8785                 8790             


Pro Ala  Lys Phe Val Lys Arg  Leu Asn Asp Tyr Ser  Ile Glu Lys 
    8795                 8800                 8805             


Gly Lys  Pro Leu Ile Leu Glu  Gly Thr Phe Thr Gly  Thr Pro Pro 
    8810                 8815                 8820             


Ile Ser  Val Thr Trp Lys Lys  Asn Gly Ile Asn Val  Thr Pro Ser 
    8825                 8830                 8835             


Gln Arg  Cys Asn Ile Thr Thr  Thr Glu Lys Ser Ala  Ile Leu Glu 
    8840                 8845                 8850             


Ile Pro  Ser Ser Thr Val Glu  Asp Ala Gly Gln Tyr  Asn Cys Tyr 
    8855                 8860                 8865             


Ile Glu  Asn Ala Ser Gly Lys  Asp Ser Cys Ser Ala  Gln Ile Leu 
    8870                 8875                 8880             


Ile Leu  Glu Pro Pro Tyr Phe  Val Lys Gln Leu Glu  Pro Val Lys 
    8885                 8890                 8895             


Val Ser  Val Gly Asp Ser Ala  Ser Leu Gln Cys Gln  Leu Ala Gly 
    8900                 8905                 8910             


Thr Pro  Glu Ile Gly Val Ser  Trp Tyr Lys Gly Asp  Thr Lys Leu 
    8915                 8920                 8925             


Arg Pro  Thr Thr Thr Tyr Lys  Met His Phe Arg Asn  Asn Val Ala 
    8930                 8935                 8940             


Thr Leu  Val Phe Asn Gln Val  Asp Ile Asn Asp Ser  Gly Glu Tyr 
    8945                 8950                 8955             


Ile Cys  Lys Ala Glu Asn Ser  Val Gly Glu Val Ser  Ala Ser Thr 
    8960                 8965                 8970             


Phe Leu  Thr Val Gln Glu Gln  Lys Leu Pro Pro Ser  Phe Ser Arg 
    8975                 8980                 8985             


Gln Leu  Arg Asp Val Gln Glu  Thr Val Gly Leu Pro  Val Val Phe 
    8990                 8995                 9000             


Asp Cys  Ala Ile Ser Gly Ser  Glu Pro Ile Ser Val  Ser Trp Tyr 
    9005                 9010                 9015             


Lys Asp  Gly Lys Pro Leu Lys  Asp Ser Pro Asn Val  Gln Thr Ser 
    9020                 9025                 9030             


Phe Leu  Asp Asn Thr Ala Thr  Leu Asn Ile Phe Lys  Thr Asp Arg 
    9035                 9040                 9045             


Ser Leu  Ala Gly Gln Tyr Ser  Cys Thr Ala Thr Asn  Pro Ile Gly 
    9050                 9055                 9060             


Ser Ala  Ser Ser Ser Ala Arg  Leu Ile Leu Thr Glu  Gly Lys Asn 
    9065                 9070                 9075             


Pro Pro  Phe Phe Asp Ile Arg  Leu Ala Pro Val Asp  Ala Val Val 
    9080                 9085                 9090             


Gly Glu  Ser Ala Asp Phe Glu  Cys His Val Thr Gly  Thr Gln Pro 
    9095                 9100                 9105             


Ile Lys  Val Ser Trp Ala Lys  Asp Ser Arg Glu Ile  Arg Ser Gly 
    9110                 9115                 9120             


Gly Lys  Tyr Gln Ile Ser Tyr  Leu Glu Asn Ser Ala  His Leu Thr 
    9125                 9130                 9135             


Val Leu  Lys Val Asp Lys Gly  Asp Ser Gly Gln Tyr  Thr Cys Tyr 
    9140                 9145                 9150             


Ala Val  Asn Glu Val Gly Lys  Asp Ser Cys Thr Ala  Gln Leu Asn 
    9155                 9160                 9165             


Ile Lys  Glu Arg Leu Ile Pro  Pro Ser Phe Thr Lys  Arg Leu Ser 
    9170                 9175                 9180             


Glu Thr  Val Glu Glu Thr Glu  Gly Asn Ser Phe Lys  Leu Glu Gly 
    9185                 9190                 9195             


Arg Val  Ala Gly Ser Gln Pro  Ile Thr Val Ala Trp  Tyr Lys Asn 
    9200                 9205                 9210             


Asn Ile  Glu Ile Gln Pro Thr  Ser Asn Cys Glu Ile  Thr Phe Lys 
    9215                 9220                 9225             


Asn Asn  Thr Leu Val Leu Gln  Val Arg Lys Ala Gly  Met Asn Asp 
    9230                 9235                 9240             


Ala Gly  Leu Tyr Thr Cys Lys  Val Ser Asn Asp Ala  Gly Ser Ala 
    9245                 9250                 9255             


Leu Cys  Thr Ser Ser Ile Val  Ile Lys Glu Pro Lys  Lys Pro Pro 
    9260                 9265                 9270             


Val Phe  Asp Gln His Leu Thr  Pro Val Thr Val Ser  Glu Gly Glu 
    9275                 9280                 9285             


Tyr Val  Gln Leu Ser Cys His  Val Gln Gly Ser Glu  Pro Ile Arg 
    9290                 9295                 9300             


Ile Gln  Trp Leu Lys Ala Gly  Arg Glu Ile Lys Pro  Ser Asp Arg 
    9305                 9310                 9315             


Cys Ser  Phe Ser Phe Ala Ser  Gly Thr Ala Val Leu  Glu Leu Arg 
    9320                 9325                 9330             


Asp Val  Ala Lys Ala Asp Ser  Gly Asp Tyr Val Cys  Lys Ala Ser 
    9335                 9340                 9345             


Asn Val  Ala Gly Ser Asp Thr  Thr Lys Ser Lys Val  Thr Ile Lys 
    9350                 9355                 9360             


Asp Lys  Pro Ala Val Ala Pro  Ala Thr Lys Lys Ala  Ala Val Asp 
    9365                 9370                 9375             


Gly Arg  Leu Phe Phe Val Ser  Glu Pro Gln Ser Ile  Arg Val Val 
    9380                 9385                 9390             


Glu Lys  Thr Thr Ala Thr Phe  Ile Ala Lys Val Gly  Gly Asp Pro 
    9395                 9400                 9405             


Ile Pro  Asn Val Lys Trp Thr  Lys Gly Lys Trp Arg  Gln Leu Asn 
    9410                 9415                 9420             


Gln Gly  Gly Arg Val Phe Ile  His Gln Lys Gly Asp  Glu Ala Lys 
    9425                 9430                 9435             


Leu Glu  Ile Arg Asp Thr Thr  Lys Thr Asp Ser Gly  Leu Tyr Arg 
    9440                 9445                 9450             


Cys Val  Ala Phe Asn Glu His  Gly Glu Ile Glu Ser  Asn Val Asn 
    9455                 9460                 9465             


Leu Gln  Val Asp Glu Arg Lys  Lys Gln Glu Lys Ile  Glu Gly Asp 
    9470                 9475                 9480             


Leu Arg  Ala Met Leu Lys Lys  Thr Pro Ile Leu Lys  Lys Gly Ala 
    9485                 9490                 9495             


Gly Glu  Glu Glu Glu Ile Asp  Ile Met Glu Leu Leu  Lys Asn Val 
    9500                 9505                 9510             


Asp Pro  Lys Glu Tyr Glu Lys  Tyr Ala Arg Met Tyr  Gly Ile Thr 
    9515                 9520                 9525             


Asp Phe  Arg Gly Leu Leu Gln  Ala Phe Glu Leu Leu  Lys Gln Ser 
    9530                 9535                 9540             


Gln Glu  Glu Glu Thr His Arg  Leu Glu Ile Glu Glu  Ile Glu Arg 
    9545                 9550                 9555             


Ser Glu  Arg Asp Glu Lys Glu  Phe Glu Glu Leu Val  Ser Phe Ile 
    9560                 9565                 9570             


Gln Gln  Arg Leu Ser Gln Thr  Glu Pro Val Thr Leu  Ile Lys Asp 
    9575                 9580                 9585             


Ile Glu  Asn Gln Thr Val Leu  Lys Asp Asn Asp Ala  Val Phe Glu 
    9590                 9595                 9600             


Ile Asp  Ile Lys Ile Asn Tyr  Pro Glu Ile Lys Leu  Ser Trp Tyr 
    9605                 9610                 9615             


Lys Gly  Thr Glu Lys Leu Glu  Pro Ser Asp Lys Phe  Glu Ile Ser 
    9620                 9625                 9630             


Ile Asp  Gly Asp Arg His Thr  Leu Arg Val Lys Asn  Cys Gln Leu 
    9635                 9640                 9645             


Lys Asp  Gln Gly Asn Tyr Arg  Leu Val Cys Gly Pro  His Ile Ala 
    9650                 9655                 9660             


Ser Ala  Lys Leu Thr Val Ile  Glu Pro Ala Trp Glu  Arg His Leu 
    9665                 9670                 9675             


Gln Asp  Val Thr Leu Lys Glu  Gly Gln Thr Cys Thr  Met Thr Cys 
    9680                 9685                 9690             


Gln Phe  Ser Val Pro Asn Val  Lys Ser Glu Trp Phe  Arg Asn Gly 
    9695                 9700                 9705             


Arg Ile  Leu Lys Pro Gln Gly  Arg His Lys Thr Glu  Val Glu His 
    9710                 9715                 9720             


Lys Val  His Lys Leu Thr Ile  Ala Asp Val Arg Ala  Glu Asp Gln 
    9725                 9730                 9735             


Gly Gln  Tyr Thr Cys Lys Tyr  Glu Asp Leu Glu Thr  Ser Ala Glu 
    9740                 9745                 9750             


Leu Arg  Ile Glu Ala Glu Pro  Ile Gln Phe Thr Lys  Arg Ile Gln 
    9755                 9760                 9765             


Asn Ile  Val Val Ser Glu His  Gln Ser Ala Thr Phe  Glu Cys Glu 
    9770                 9775                 9780             


Val Ser  Phe Asp Asp Ala Ile  Val Thr Trp Tyr Lys  Gly Pro Thr 
    9785                 9790                 9795             


Glu Leu  Thr Glu Ser Gln Lys  Tyr Asn Phe Arg Asn  Asp Gly Arg 
    9800                 9805                 9810             


Cys His  Tyr Met Thr Ile His  Asn Val Thr Pro Asp  Asp Glu Gly 
    9815                 9820                 9825             


Val Tyr  Ser Val Ile Ala Arg  Leu Glu Pro Arg Gly  Glu Ala Arg 
    9830                 9835                 9840             


Ser Thr  Ala Glu Leu Tyr Leu  Thr Thr Lys Glu Ile  Lys Leu Glu 
    9845                 9850                 9855             


Leu Lys  Pro Pro Asp Ile Pro  Asp Ser Arg Val Pro  Ile Pro Thr 
    9860                 9865                 9870             


Met Pro  Ile Arg Ala Val Pro  Pro Glu Glu Ile Pro  Pro Val Val 
    9875                 9880                 9885             


Ala Pro  Pro Ile Pro Leu Leu  Leu Pro Thr Pro Glu  Glu Lys Lys 
    9890                 9895                 9900             


Pro Pro  Pro Lys Arg Ile Glu  Val Thr Lys Lys Ala  Val Lys Lys 
    9905                 9910                 9915             


Asp Ala  Lys Lys Val Val Ala  Lys Pro Lys Glu Met  Thr Pro Arg 
    9920                 9925                 9930             


Glu Glu  Ile Val Lys Lys Pro  Pro Pro Pro Thr Thr  Leu Ile Pro 
    9935                 9940                 9945             


Ala Lys  Ala Pro Glu Ile Ile  Asp Val Ser Ser Lys  Ala Glu Glu 
    9950                 9955                 9960             


Val Lys  Ile Met Thr Ile Thr  Arg Lys Lys Glu Val  Gln Lys Glu 
    9965                 9970                 9975             


Lys Glu  Ala Val Tyr Glu Lys  Lys Gln Ala Val His  Lys Glu Lys 
    9980                 9985                 9990             


Arg Val  Phe Ile Glu Ser Phe   Glu Glu Pro Tyr Asp   Glu Leu Glu 
    9995                 10000                 10005             


Val Glu   Pro Tyr Thr Glu Pro   Phe Glu Gln Pro Tyr   Tyr Glu Glu 
    10010                 10015                 10020             


Pro Asp   Glu Asp Tyr Glu Glu   Ile Lys Val Glu Ala   Lys Lys Glu 
    10025                 10030                 10035             


Val His   Glu Glu Trp Glu Glu   Asp Phe Glu Glu Gly   Gln Glu Tyr 
    10040                 10045                 10050             


Tyr Glu   Arg Glu Glu Gly Tyr   Asp Glu Gly Glu Glu   Glu Trp Glu 
    10055                 10060                 10065             


Glu Ala   Tyr Gln Glu Arg Glu   Val Ile Gln Val Gln   Lys Glu Val 
    10070                 10075                 10080             


Tyr Glu   Glu Ser His Glu Arg   Lys Val Pro Ala Lys   Val Pro Glu 
    10085                 10090                 10095             


Lys Lys   Ala Pro Pro Pro Pro   Lys Val Ile Lys Lys   Pro Val Ile 
    10100                 10105                 10110             


Glu Lys   Ile Glu Lys Thr Ser   Arg Arg Met Glu Glu   Glu Lys Val 
    10115                 10120                 10125             


Gln Val   Thr Lys Val Pro Glu   Val Ser Lys Lys Ile   Val Pro Gln 
    10130                 10135                 10140             


Lys Pro   Ser Arg Thr Pro Val   Gln Glu Glu Val Ile   Glu Val Lys 
    10145                 10150                 10155             


Val Pro   Ala Val His Thr Lys   Lys Met Val Ile Ser   Glu Glu Lys 
    10160                 10165                 10170             


Met Phe   Phe Ala Ser His Thr   Glu Glu Glu Val Ser   Val Thr Val 
    10175                 10180                 10185             


Pro Glu   Val Gln Lys Glu Ile   Val Thr Glu Glu Lys   Ile His Val 
    10190                 10195                 10200             


Ala Val   Ser Lys Arg Val Glu   Pro Pro Pro Lys Val   Pro Glu Leu 
    10205                 10210                 10215             


Pro Glu   Lys Pro Ala Pro Glu   Glu Val Ala Pro Val   Pro Ile Pro 
    10220                 10225                 10230             


Lys Lys   Val Glu Pro Pro Ala   Pro Lys Val Pro Glu   Val Pro Lys 
    10235                 10240                 10245             


Lys Pro   Val Pro Glu Glu Lys   Lys Pro Val Pro Val   Pro Lys Lys 
    10250                 10255                 10260             


Glu Pro   Ala Ala Pro Pro Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10265                 10270                 10275             


Val Pro   Glu Glu Lys Ile Pro   Val Pro Val Ala Lys   Lys Lys Glu 
    10280                 10285                 10290             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Gln Lys Arg   Val Val Thr 
    10295                 10300                 10305             


Glu Glu   Lys Ile Thr Ile Val   Thr Gln Arg Glu Glu   Ser Pro Pro 
    10310                 10315                 10320             


Pro Ala   Val Pro Glu Ile Pro   Lys Lys Lys Val Pro   Glu Glu Arg 
    10325                 10330                 10335             


Lys Pro   Val Pro Arg Lys Glu   Glu Glu Val Pro Pro   Pro Pro Lys 
    10340                 10345                 10350             


Val Pro   Ala Leu Pro Lys Lys   Pro Val Pro Glu Glu   Lys Val Ala 
    10355                 10360                 10365             


Val Pro   Val Pro Val Ala Lys   Lys Ala Pro Pro Pro   Arg Ala Glu 
    10370                 10375                 10380             


Val Ser   Lys Lys Thr Val Val   Glu Glu Lys Arg Phe   Val Ala Glu 
    10385                 10390                 10395             


Glu Lys   Leu Ser Phe Ala Val   Pro Gln Arg Val Glu   Val Thr Arg 
    10400                 10405                 10410             


His Glu   Val Ser Ala Glu Glu   Glu Trp Ser Tyr Ser   Glu Glu Glu 
    10415                 10420                 10425             


Glu Gly   Val Ser Ile Ser Val   Tyr Arg Glu Glu Glu   Arg Glu Glu 
    10430                 10435                 10440             


Glu Glu   Glu Ala Glu Val Thr   Glu Tyr Glu Val Met   Glu Glu Pro 
    10445                 10450                 10455             


Glu Glu   Tyr Val Val Glu Glu   Lys Leu His Ile Ile   Ser Lys Arg 
    10460                 10465                 10470             


Val Glu   Ala Glu Pro Ala Glu   Val Thr Glu Arg Gln   Glu Lys Lys 
    10475                 10480                 10485             


Ile Val   Leu Lys Pro Lys Ile   Pro Ala Lys Ile Glu   Glu Pro Pro 
    10490                 10495                 10500             


Pro Ala   Lys Val Pro Glu Ala   Pro Lys Lys Ile Val   Pro Glu Lys 
    10505                 10510                 10515             


Lys Val   Pro Ala Pro Val Pro   Lys Lys Glu Lys Val   Pro Pro Pro 
    10520                 10525                 10530             


Lys Val   Pro Glu Glu Pro Lys   Lys Pro Val Pro Glu   Lys Lys Val 
    10535                 10540                 10545             


Pro Pro   Lys Val Ile Lys Met   Glu Glu Pro Leu Pro   Ala Lys Val 
    10550                 10555                 10560             


Thr Glu   Arg His Met Gln Ile   Thr Gln Glu Glu Lys   Val Leu Val 
    10565                 10570                 10575             


Ala Val   Thr Lys Lys Glu Ala   Pro Pro Lys Ala Arg   Val Pro Glu 
    10580                 10585                 10590             


Glu Pro   Lys Arg Ala Val Pro   Glu Glu Lys Val Leu   Lys Leu Lys 
    10595                 10600                 10605             


Pro Lys   Arg Glu Glu Glu Pro   Pro Ala Lys Val Thr   Glu Phe Arg 
    10610                 10615                 10620             


Lys Arg   Val Val Lys Glu Glu   Lys Val Ser Ile Glu   Ala Pro Lys 
    10625                 10630                 10635             


Arg Glu   Pro Gln Pro Ile Lys   Glu Val Thr Ile Met   Glu Glu Lys 
    10640                 10645                 10650             


Glu Arg   Ala Tyr Thr Leu Glu   Glu Glu Ala Val Ser   Val Gln Arg 
    10655                 10660                 10665             


Glu Glu   Glu Tyr Glu Glu Tyr   Glu Glu Tyr Asp Tyr   Lys Glu Phe 
    10670                 10675                 10680             


Glu Glu   Tyr Glu Pro Thr Glu   Glu Tyr Asp Gln Tyr   Glu Glu Tyr 
    10685                 10690                 10695             


Glu Glu   Arg Glu Tyr Glu Arg   Tyr Glu Glu His Glu   Glu Tyr Ile 
    10700                 10705                 10710             


Thr Glu   Pro Glu Lys Pro Ile   Pro Val Lys Pro Val   Pro Glu Glu 
    10715                 10720                 10725             


Pro Val   Pro Thr Lys Pro Lys   Ala Pro Pro Ala Lys   Val Leu Lys 
    10730                 10735                 10740             


Lys Ala   Val Pro Glu Glu Lys   Val Pro Val Pro Ile   Pro Lys Lys 
    10745                 10750                 10755             


Leu Lys   Pro Pro Pro Pro Lys   Val Pro Glu Glu Pro   Lys Lys Val 
    10760                 10765                 10770             


Phe Glu   Glu Lys Ile Arg Ile   Ser Ile Thr Lys Arg   Glu Lys Glu 
    10775                 10780                 10785             


Gln Val   Thr Glu Pro Ala Ala   Lys Val Pro Met Lys   Pro Lys Arg 
    10790                 10795                 10800             


Val Val   Ala Glu Glu Lys Val   Pro Val Pro Arg Lys   Glu Val Ala 
    10805                 10810                 10815             


Pro Pro   Val Arg Val Pro Glu   Val Pro Lys Glu Leu   Glu Pro Glu 
    10820                 10825                 10830             


Glu Val   Ala Phe Glu Glu Glu   Val Val Thr His Val   Glu Glu Tyr 
    10835                 10840                 10845             


Leu Val   Glu Glu Glu Glu Glu   Tyr Ile His Glu Glu   Glu Glu Phe 
    10850                 10855                 10860             


Ile Thr   Glu Glu Glu Val Val   Pro Val Ile Pro Val   Lys Val Pro 
    10865                 10870                 10875             


Glu Val   Pro Arg Lys Pro Val   Pro Glu Glu Lys Lys   Pro Val Pro 
    10880                 10885                 10890             


Val Pro   Lys Lys Lys Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val 
    10895                 10900                 10905             


Pro Lys   Lys Pro Glu Glu Lys   Val Pro Val Leu Ile   Pro Lys Lys 
    10910                 10915                 10920             


Glu Lys   Pro Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10925                 10930                 10935             


Val Pro   Glu Glu Lys Val Pro   Val Pro Val Pro Lys   Lys Val Glu 
    10940                 10945                 10950             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Pro Val Pro 
    10955                 10960                 10965             


Glu Lys   Lys Val Pro Val Pro   Ala Pro Lys Lys Val   Glu Ala Pro 
    10970                 10975                 10980             


Pro Ala   Lys Val Pro Glu Val   Pro Lys Lys Leu Ile   Pro Glu Glu 
    10985                 10990                 10995             


Lys Lys   Pro Thr Pro Val Pro   Lys Lys Val Glu Ala   Pro Pro Pro 
    11000                 11005                 11010             


Lys Val   Pro Lys Lys Arg Glu   Pro Val Pro Val Pro   Val Ala Leu 
    11015                 11020                 11025             


Pro Gln   Glu Glu Glu Val Leu   Phe Glu Glu Glu Ile   Val Pro Glu 
    11030                 11035                 11040             


Glu Glu   Val Leu Pro Glu Glu   Glu Glu Val Leu Pro   Glu Glu Glu 
    11045                 11050                 11055             


Glu Val   Leu Pro Glu Glu Glu   Glu Val Leu Pro Glu   Glu Glu Glu 
    11060                 11065                 11070             


Ile Pro   Pro Glu Glu Glu Glu   Val Pro Pro Glu Glu   Glu Tyr Val 
    11075                 11080                 11085             


Pro Glu   Glu Glu Glu Phe Val   Pro Glu Glu Glu Val   Leu Pro Glu 
    11090                 11095                 11100             


Val Lys   Pro Lys Val Pro Val   Pro Ala Pro Val Pro   Glu Ile Lys 
    11105                 11110                 11115             


Lys Lys   Val Thr Glu Lys Lys   Val Val Ile Pro Lys   Lys Glu Glu 
    11120                 11125                 11130             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Val Glu Glu 
    11135                 11140                 11145             


Lys Arg   Ile Ile Leu Pro Lys   Glu Glu Glu Val Leu   Pro Val Glu 
    11150                 11155                 11160             


Val Thr   Glu Glu Pro Glu Glu   Glu Pro Ile Ser Glu   Glu Glu Ile 
    11165                 11170                 11175             


Pro Glu   Glu Pro Pro Ser Ile   Glu Glu Val Glu Glu   Val Ala Pro 
    11180                 11185                 11190             


Pro Arg   Val Pro Glu Val Ile   Lys Lys Ala Val Pro   Glu Ala Pro 
    11195                 11200                 11205             


Thr Pro   Val Pro Lys Lys Val   Glu Ala Pro Pro Ala   Lys Val Ser 
    11210                 11215                 11220             


Lys Lys   Ile Pro Glu Glu Lys   Val Pro Val Pro Val   Gln Lys Lys 
    11225                 11230                 11235             


Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val Pro Lys   Lys Val Pro 
    11240                 11245                 11250             


Glu Lys   Lys Val Leu Val Pro   Lys Lys Glu Ala Val   Pro Pro Ala 
    11255                 11260                 11265             


Lys Gly   Arg Thr Val Leu Glu   Glu Lys Val Ser Val   Ala Phe Arg 
    11270                 11275                 11280             


Gln Glu   Val Val Val Lys Glu   Arg Leu Glu Leu Glu   Val Val Glu 
    11285                 11290                 11295             


Ala Glu   Val Glu Glu Ile Pro   Glu Glu Glu Glu Phe   His Glu Val 
    11300                 11305                 11310             


Glu Glu   Tyr Phe Glu Glu Gly   Glu Phe His Glu Val   Glu Glu Phe 
    11315                 11320                 11325             


Ile Lys   Leu Glu Gln His Arg   Val Glu Glu Glu His   Arg Val Glu 
    11330                 11335                 11340             


Lys Val   His Arg Val Ile Glu   Val Phe Glu Ala Glu   Glu Val Glu 
    11345                 11350                 11355             


Val Phe   Glu Lys Pro Lys Ala   Pro Pro Lys Gly Pro   Glu Ile Ser 
    11360                 11365                 11370             


Glu Lys   Ile Ile Pro Pro Lys   Lys Pro Pro Thr Lys   Val Val Pro 
    11375                 11380                 11385             


Arg Lys   Glu Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Ile 
    11390                 11395                 11400             


Val Val   Glu Glu Lys Val Arg   Val Pro Glu Glu Pro   Arg Val Pro 
    11405                 11410                 11415             


Pro Thr   Lys Val Pro Asp Val   Leu Pro Pro Lys Glu   Val Val Pro 
    11420                 11425                 11430             


Glu Lys   Lys Val Pro Val Pro   Pro Ala Lys Lys Pro   Glu Ala Pro 
    11435                 11440                 11445             


Pro Pro   Lys Val Pro Glu Ala   Pro Lys Glu Val Val   Pro Glu Lys 
    11450                 11455                 11460             


Lys Val   Pro Val Pro Pro Pro   Lys Lys Pro Glu Val   Pro Pro Thr 
    11465                 11470                 11475             


Lys Val   Pro Glu Val Pro Lys   Ala Ala Val Pro Glu   Lys Lys Val 
    11480                 11485                 11490             


Pro Glu   Ala Ile Pro Pro Lys   Pro Glu Ser Pro Pro   Pro Glu Val 
    11495                 11500                 11505             


Pro Glu   Ala Pro Lys Glu Val   Val Pro Glu Lys Lys   Val Pro Ala 
    11510                 11515                 11520             


Ala Pro   Pro Lys Lys Pro Glu   Val Thr Pro Val Lys   Val Pro Glu 
    11525                 11530                 11535             


Ala Pro   Lys Glu Val Val Pro   Glu Lys Lys Val Pro   Val Pro Pro 
    11540                 11545                 11550             


Pro Lys   Lys Pro Glu Val Pro   Pro Thr Lys Val Pro   Glu Val Pro 
    11555                 11560                 11565             


Lys Val   Ala Val Pro Glu Lys   Lys Val Pro Glu Ala   Ile Pro Pro 
    11570                 11575                 11580             


Lys Pro   Glu Ser Pro Pro Pro   Glu Val Phe Glu Glu   Pro Glu Glu 
    11585                 11590                 11595             


Val Ala   Leu Glu Glu Pro Pro   Ala Glu Val Val Glu   Glu Pro Glu 
    11600                 11605                 11610             


Pro Ala   Ala Pro Pro Gln Val   Thr Val Pro Pro Lys   Lys Pro Val 
    11615                 11620                 11625             


Pro Glu   Lys Lys Ala Pro Ala   Val Val Ala Lys Lys   Pro Glu Leu 
    11630                 11635                 11640             


Pro Pro   Val Lys Val Pro Glu   Val Pro Lys Glu Val   Val Pro Glu 
    11645                 11650                 11655             


Lys Lys   Val Pro Leu Val Val   Pro Lys Lys Pro Glu   Ala Pro Pro 
    11660                 11665                 11670             


Ala Lys   Val Pro Glu Val Pro   Lys Glu Val Val Pro   Glu Lys Lys 
    11675                 11680                 11685             


Val Ala   Val Pro Lys Lys Pro   Glu Val Pro Pro Ala   Lys Val Pro 
    11690                 11695                 11700             


Glu Val   Pro Lys Lys Pro Val   Leu Glu Glu Lys Pro   Ala Val Pro 
    11705                 11710                 11715             


Val Pro   Glu Arg Ala Glu Ser   Pro Pro Pro Glu Val   Tyr Glu Glu 
    11720                 11725                 11730             


Pro Glu   Glu Ile Ala Pro Glu   Glu Glu Ile Ala Pro   Glu Glu Glu 
    11735                 11740                 11745             


Lys Pro   Val Pro Val Ala Glu   Glu Glu Glu Pro Glu   Val Pro Pro 
    11750                 11755                 11760             


Pro Ala   Val Pro Glu Glu Pro   Lys Lys Ile Ile Pro   Glu Lys Lys 
    11765                 11770                 11775             


Val Pro   Val Ile Lys Lys Pro   Glu Ala Pro Pro Pro   Lys Glu Pro 
    11780                 11785                 11790             


Glu Pro   Glu Lys Val Ile Glu   Lys Pro Lys Leu Lys   Pro Arg Pro 
    11795                 11800                 11805             


Pro Pro   Pro Pro Pro Ala Pro   Pro Lys Glu Asp Val   Lys Glu Lys 
    11810                 11815                 11820             


Ile Phe   Gln Leu Lys Ala Ile   Pro Lys Lys Lys Val   Pro Glu Lys 
    11825                 11830                 11835             


Pro Gln   Val Pro Glu Lys Val   Glu Leu Thr Pro Leu   Lys Val Pro 
    11840                 11845                 11850             


Gly Gly   Glu Lys Lys Val Arg   Lys Leu Leu Pro Glu   Arg Lys Pro 
    11855                 11860                 11865             


Glu Pro   Lys Glu Glu Val Val   Leu Lys Ser Val Leu   Arg Lys Arg 
    11870                 11875                 11880             


Pro Glu   Glu Glu Glu Pro Lys   Val Glu Pro Lys Lys   Leu Glu Lys 
    11885                 11890                 11895             


Val Lys   Lys Pro Ala Val Pro   Glu Pro Pro Pro Pro   Lys Pro Val 
    11900                 11905                 11910             


Glu Glu   Val Glu Val Pro Thr   Val Thr Lys Arg Glu   Arg Lys Ile 
    11915                 11920                 11925             


Pro Glu   Pro Thr Lys Val Pro   Glu Ile Lys Pro Ala   Ile Pro Leu 
    11930                 11935                 11940             


Pro Ala   Pro Glu Pro Lys Pro   Lys Pro Glu Ala Glu   Val Lys Thr 
    11945                 11950                 11955             


Ile Lys   Pro Pro Pro Val Glu   Pro Glu Pro Thr Pro   Ile Ala Ala 
    11960                 11965                 11970             


Pro Val   Thr Val Pro Val Val   Gly Lys Lys Ala Glu   Ala Lys Ala 
    11975                 11980                 11985             


Pro Lys   Glu Glu Ala Ala Lys   Pro Lys Gly Pro Ile   Lys Gly Val 
    11990                 11995                 12000             


Pro Lys   Lys Thr Pro Ser Pro   Ile Glu Ala Glu Arg   Arg Lys Leu 
    12005                 12010                 12015             


Arg Pro   Gly Ser Gly Gly Glu   Lys Pro Pro Asp Glu   Ala Pro Phe 
    12020                 12025                 12030             


Thr Tyr   Gln Leu Lys Ala Val   Pro Leu Lys Phe Val   Lys Glu Ile 
    12035                 12040                 12045             


Lys Asp   Ile Ile Leu Thr Glu   Ser Glu Phe Val Gly   Ser Ser Ala 
    12050                 12055                 12060             


Ile Phe   Glu Cys Leu Val Ser   Pro Ser Thr Ala Ile   Thr Thr Trp 
    12065                 12070                 12075             


Met Lys   Asp Gly Ser Asn Ile   Arg Glu Ser Pro Lys   His Arg Phe 
    12080                 12085                 12090             


Ile Ala   Asp Gly Lys Asp Arg   Lys Leu His Ile Ile   Asp Val Gln 
    12095                 12100                 12105             


Leu Ser   Asp Ala Gly Glu Tyr   Thr Cys Val Leu Arg   Leu Gly Asn 
    12110                 12115                 12120             


Lys Glu   Lys Thr Ser Thr Ala   Lys Leu Val Val Glu   Glu Leu Pro 
    12125                 12130                 12135             


Val Arg   Phe Val Lys Thr Leu   Glu Glu Glu Val Thr   Val Val Lys 
    12140                 12145                 12150             


Gly Gln   Pro Leu Tyr Leu Ser   Cys Glu Leu Asn Lys   Glu Arg Asp 
    12155                 12160                 12165             


Val Val   Trp Arg Lys Asp Gly   Lys Ile Val Val Glu   Lys Pro Gly 
    12170                 12175                 12180             


Arg Ile   Val Pro Gly Val Ile   Gly Leu Met Arg Ala   Leu Thr Ile 
    12185                 12190                 12195             


Asn Asp   Ala Asp Asp Thr Asp   Ala Gly Thr Tyr Thr   Val Thr Val 
    12200                 12205                 12210             


Glu Asn   Ala Asn Asn Leu Glu   Cys Ser Ser Cys Val   Lys Val Val 
    12215                 12220                 12225             


Glu Val   Ile Arg Asp Trp Leu   Val Lys Pro Ile Arg   Asp Gln His 
    12230                 12235                 12240             


Val Lys   Pro Lys Gly Thr Ala   Ile Phe Ala Cys Asp   Ile Ala Lys 
    12245                 12250                 12255             


Asp Thr   Pro Asn Ile Lys Trp   Phe Lys Gly Tyr Asp   Glu Ile Pro 
    12260                 12265                 12270             


Ala Glu   Pro Asn Asp Lys Thr   Glu Ile Leu Arg Asp   Gly Asn His 
    12275                 12280                 12285             


Leu Tyr   Leu Lys Ile Lys Asn   Ala Met Pro Glu Asp   Ile Ala Glu 
    12290                 12295                 12300             


Tyr Ala   Val Glu Ile Glu Gly   Lys Arg Tyr Pro Ala   Lys Leu Thr 
    12305                 12310                 12315             


Leu Gly   Glu Arg Glu Val Glu   Leu Leu Lys Pro Ile   Glu Asp Val 
    12320                 12325                 12330             


Thr Ile   Tyr Glu Lys Glu Ser   Ala Ser Phe Asp Ala   Glu Ile Ser 
    12335                 12340                 12345             


Glu Ala   Asp Ile Pro Gly Gln   Trp Lys Leu Lys Gly   Glu Leu Leu 
    12350                 12355                 12360             


Arg Pro   Ser Pro Thr Cys Glu   Ile Lys Ala Glu Gly   Gly Lys Arg 
    12365                 12370                 12375             


Phe Leu   Thr Leu His Lys Val   Lys Leu Asp Gln Ala   Gly Glu Val 
    12380                 12385                 12390             


Leu Tyr   Gln Ala Leu Asn Ala   Ile Thr Thr Ala Ile   Leu Thr Val 
    12395                 12400                 12405             


Lys Glu   Ile Glu Leu Asp Phe   Ala Val Pro Leu Lys   Asp Val Thr 
    12410                 12415                 12420             


Val Pro   Glu Arg Arg Gln Ala   Arg Phe Glu Cys Val   Leu Thr Arg 
    12425                 12430                 12435             


Glu Ala   Asn Val Ile Trp Ser   Lys Gly Pro Asp Ile   Ile Lys Ser 
    12440                 12445                 12450             


Ser Asp   Lys Phe Asp Ile Ile   Ala Asp Gly Lys Lys   His Ile Leu 
    12455                 12460                 12465             


Val Ile   Asn Asp Ser Gln Phe   Asp Asp Glu Gly Val   Tyr Thr Ala 
    12470                 12475                 12480             


Glu Val   Glu Gly Lys Lys Thr   Ser Ala Arg Leu Phe   Val Thr Gly 
    12485                 12490                 12495             


Ile Arg   Leu Lys Phe Met Ser   Pro Leu Glu Asp Gln   Thr Val Lys 
    12500                 12505                 12510             


Glu Gly   Glu Thr Ala Thr Phe   Val Cys Glu Leu Ser   His Glu Lys 
    12515                 12520                 12525             


Met His   Val Val Trp Phe Lys   Asn Asp Ala Lys Leu   His Thr Ser 
    12530                 12535                 12540             


Arg Thr   Val Leu Ile Ser Ser   Glu Gly Lys Thr His   Lys Leu Glu 
    12545                 12550                 12555             


Met Lys   Glu Val Thr Leu Asp   Asp Ile Ser Gln Ile   Lys Ala Gln 
    12560                 12565                 12570             


Val Lys   Glu Leu Ser Ser Thr   Ala Gln Leu Lys Val   Leu Glu Ala 
    12575                 12580                 12585             


Asp Pro   Tyr Phe Thr Val Lys   Leu His Asp Lys Thr   Ala Val Glu 
    12590                 12595                 12600             


Lys Asp   Glu Ile Thr Leu Lys   Cys Glu Val Ser Lys   Asp Val Pro 
    12605                 12610                 12615             


Val Lys   Trp Phe Lys Asp Gly   Glu Glu Ile Val Pro   Ser Pro Lys 
    12620                 12625                 12630             


Tyr Ser   Ile Lys Ala Asp Gly   Leu Arg Arg Ile Leu   Lys Ile Lys 
    12635                 12640                 12645             


Lys Ala   Asp Leu Lys Asp Lys   Gly Glu Tyr Val Cys   Asp Cys Gly 
    12650                 12655                 12660             


Thr Asp   Lys Thr Lys Ala Asn   Val Thr Val Glu Ala   Arg Leu Ile 
    12665                 12670                 12675             


Lys Val   Glu Lys Pro Leu Tyr   Gly Val Glu Val Phe   Val Gly Glu 
    12680                 12685                 12690             


Thr Ala   His Phe Glu Ile Glu   Leu Ser Glu Pro Asp   Val His Gly 
    12695                 12700                 12705             


Gln Trp   Lys Leu Lys Gly Gln   Pro Leu Thr Ala Ser   Pro Asp Cys 
    12710                 12715                 12720             


Glu Ile   Ile Glu Asp Gly Lys   Lys His Ile Leu Ile   Leu His Asn 
    12725                 12730                 12735             


Cys Gln   Leu Gly Met Thr Gly   Glu Val Ser Phe Gln   Ala Ala Asn 
    12740                 12745                 12750             


Ala Lys   Ser Ala Ala Asn Leu   Lys Val Lys Glu Leu   Pro Leu Ile 
    12755                 12760                 12765             


Phe Ile   Thr Pro Leu Ser Asp   Val Lys Val Phe Glu   Lys Asp Glu 
    12770                 12775                 12780             


Ala Lys   Phe Glu Cys Glu Val   Ser Arg Glu Pro Lys   Thr Phe Arg 
    12785                 12790                 12795             


Trp Leu   Lys Gly Thr Gln Glu   Ile Thr Gly Asp Asp   Arg Phe Glu 
    12800                 12805                 12810             


Leu Ile   Lys Asp Gly Thr Lys   His Ser Met Val Ile   Lys Ser Ala 
    12815                 12820                 12825             


Ala Phe   Glu Asp Glu Ala Lys   Tyr Met Phe Glu Ala   Glu Asp Lys 
    12830                 12835                 12840             


His Thr   Ser Gly Lys Leu Ile   Ile Glu Gly Ile Arg   Leu Lys Phe 
    12845                 12850                 12855             


Leu Thr   Pro Leu Lys Asp Val   Thr Ala Lys Glu Lys   Glu Ser Ala 
    12860                 12865                 12870             


Val Phe   Thr Val Glu Leu Ser   His Asp Asn Ile Arg   Val Lys Trp 
    12875                 12880                 12885             


Phe Lys   Asn Asp Gln Arg Leu   His Thr Thr Arg Ser   Val Ser Met 
    12890                 12895                 12900             


Gln Asp   Glu Gly Lys Thr His   Ser Ile Thr Phe Lys   Asp Leu Ser 
    12905                 12910                 12915             


Ile Asp   Asp Thr Ser Gln Ile   Arg Val Glu Ala Met   Gly Met Ser 
    12920                 12925                 12930             


Ser Glu   Ala Lys Leu Thr Val   Leu Glu Gly Asp Pro   Tyr Phe Thr 
    12935                 12940                 12945             


Gly Lys   Leu Gln Asp Tyr Thr   Gly Val Glu Lys Asp   Glu Val Ile 
    12950                 12955                 12960             


Leu Gln   Cys Glu Ile Ser Lys   Ala Asp Ala Pro Val   Lys Trp Phe 
    12965                 12970                 12975             


Lys Asp   Gly Lys Glu Ile Lys   Pro Ser Lys Asn Ala   Val Ile Lys 
    12980                 12985                 12990             


Ala Asp   Gly Lys Lys Arg Met   Leu Ile Leu Lys Lys   Ala Leu Lys 
    12995                 13000                 13005             


Ser Asp   Ile Gly Gln Tyr Thr   Cys Asp Cys Gly Thr   Asp Lys Thr 
    13010                 13015                 13020             


Ser Gly   Lys Leu Asp Ile Glu   Asp Arg Glu Ile Lys   Leu Val Arg 
    13025                 13030                 13035             


Pro Leu   His Ser Val Glu Val   Met Glu Thr Glu Thr   Ala Arg Phe 
    13040                 13045                 13050             


Glu Thr   Glu Ile Ser Glu Asp   Asp Ile His Ala Asn   Trp Lys Leu 
    13055                 13060                 13065             


Lys Gly   Glu Ala Leu Leu Gln   Thr Pro Asp Cys Glu   Ile Lys Glu 
    13070                 13075                 13080             


Glu Gly   Lys Ile His Ser Leu   Val Leu His Asn Cys   Arg Leu Asp 
    13085                 13090                 13095             


Gln Thr   Gly Gly Val Asp Phe   Gln Ala Ala Asn Val   Lys Ser Ser 
    13100                 13105                 13110             


Ala His   Leu Arg Val Lys Pro   Arg Val Ile Gly Leu   Leu Arg Pro 
    13115                 13120                 13125             


Leu Lys   Asp Val Thr Val Thr   Ala Gly Glu Thr Ala   Thr Phe Asp 
    13130                 13135                 13140             


Cys Glu   Leu Ser Tyr Glu Asp   Ile Pro Val Glu Trp   Tyr Leu Lys 
    13145                 13150                 13155             


Gly Lys   Lys Leu Glu Pro Ser   Asp Lys Val Val Pro   Arg Ser Glu 
    13160                 13165                 13170             


Gly Lys   Val His Thr Leu Thr   Leu Arg Asp Val Lys   Leu Glu Asp 
    13175                 13180                 13185             


Ala Gly   Glu Val Gln Leu Thr   Ala Lys Asp Phe Lys   Thr His Ala 
    13190                 13195                 13200             


Asn Leu   Phe Val Lys Glu Pro   Pro Val Glu Phe Thr   Lys Pro Leu 
    13205                 13210                 13215             


Glu Asp   Gln Thr Val Glu Glu   Gly Ala Thr Ala Val   Leu Glu Cys 
    13220                 13225                 13230             


Glu Val   Ser Arg Glu Asn Ala   Lys Val Lys Trp Phe   Lys Asn Gly 
    13235                 13240                 13245             


Thr Glu   Ile Leu Lys Ser Lys   Lys Tyr Glu Ile Val   Ala Asp Gly 
    13250                 13255                 13260             


Arg Val   Arg Lys Leu Val Ile   His Asp Cys Thr Pro   Glu Asp Ile 
    13265                 13270                 13275             


Lys Thr   Tyr Thr Cys Asp Ala   Lys Asp Phe Lys Thr   Ser Cys Asn 
    13280                 13285                 13290             


Leu Asn   Val Val Pro Pro His   Val Glu Phe Leu Arg   Pro Leu Thr 
    13295                 13300                 13305             


Asp Leu   Gln Val Arg Glu Lys   Glu Met Ala Arg Phe   Glu Cys Glu 
    13310                 13315                 13320             


Leu Ser   Arg Glu Asn Ala Lys   Val Lys Trp Phe Lys   Asp Gly Ala 
    13325                 13330                 13335             


Glu Ile   Lys Lys Gly Lys Lys   Tyr Asp Ile Ile Ser   Lys Gly Ala 
    13340                 13345                 13350             


Val Arg   Ile Leu Val Ile Asn   Lys Cys Leu Leu Asp   Asp Glu Ala 
    13355                 13360                 13365             


Glu Tyr   Ser Cys Glu Val Arg   Thr Ala Arg Thr Ser   Gly Met Leu 
    13370                 13375                 13380             


Thr Val   Leu Glu Glu Glu Ala   Val Phe Thr Lys Asn   Leu Ala Asn 
    13385                 13390                 13395             


Ile Glu   Val Ser Glu Thr Asp   Thr Ile Lys Leu Val   Cys Glu Val 
    13400                 13405                 13410             


Ser Lys   Pro Gly Ala Glu Val   Ile Trp Tyr Lys Gly   Asp Glu Glu 
    13415                 13420                 13425             


Ile Ile   Glu Thr Gly Arg Tyr   Glu Ile Leu Thr Glu   Gly Arg Lys 
    13430                 13435                 13440             


Arg Ile   Leu Val Ile Gln Asn   Ala His Leu Glu Asp   Ala Gly Asn 
    13445                 13450                 13455             


Tyr Asn   Cys Arg Leu Pro Ser   Ser Arg Thr Asp Gly   Lys Val Lys 
    13460                 13465                 13470             


Val His   Glu Leu Ala Ala Glu   Phe Ile Ser Lys Pro   Gln Asn Leu 
    13475                 13480                 13485             


Glu Ile   Leu Glu Gly Glu Lys   Ala Glu Phe Val Cys   Ser Ile Ser 
    13490                 13495                 13500             


Lys Glu   Ser Phe Pro Val Gln   Trp Lys Arg Asp Asp   Lys Thr Leu 
    13505                 13510                 13515             


Glu Ser   Gly Asp Lys Tyr Asp   Val Ile Ala Asp Gly   Lys Lys Arg 
    13520                 13525                 13530             


Val Leu   Val Val Lys Asp Ala   Thr Leu Gln Asp Met   Gly Thr Tyr 
    13535                 13540                 13545             


Val Val   Met Val Gly Ala Ala   Arg Ala Ala Ala His   Leu Thr Val 
    13550                 13555                 13560             


Ile Glu   Lys Leu Arg Ile Val   Val Pro Leu Lys Asp   Thr Arg Val 
    13565                 13570                 13575             


Lys Glu   Gln Gln Glu Val Val   Phe Asn Cys Glu Val   Asn Thr Glu 
    13580                 13585                 13590             


Gly Ala   Lys Ala Lys Trp Phe   Arg Asn Glu Glu Ala   Ile Phe Asp 
    13595                 13600                 13605             


Ser Ser   Lys Tyr Ile Ile Leu   Gln Lys Asp Leu Val   Tyr Thr Leu 
    13610                 13615                 13620             


Arg Ile   Arg Asp Ala His Leu   Asp Asp Gln Ala Asn   Tyr Asn Val 
    13625                 13630                 13635             


Ser Leu   Thr Asn His Arg Gly   Glu Asn Val Lys Ser   Ala Ala Asn 
    13640                 13645                 13650             


Leu Ile   Val Glu Glu Glu Asp   Leu Arg Ile Val Glu   Pro Leu Lys 
    13655                 13660                 13665             


Asp Ile   Glu Thr Met Glu Lys   Lys Ser Val Thr Phe   Trp Cys Lys 
    13670                 13675                 13680             


Val Asn   Arg Leu Asn Val Thr   Leu Lys Trp Thr Lys   Asn Gly Glu 
    13685                 13690                 13695             


Glu Val   Pro Phe Asp Asn Arg   Val Ser Tyr Arg Val   Asp Lys Tyr 
    13700                 13705                 13710             


Lys His   Met Leu Thr Ile Lys   Asp Cys Gly Phe Pro   Asp Glu Gly 
    13715                 13720                 13725             


Glu Tyr   Ile Val Thr Ala Gly   Gln Asp Lys Ser Val   Ala Glu Leu 
    13730                 13735                 13740             


Leu Ile   Ile Glu Ala Pro Thr   Glu Phe Val Glu His   Leu Glu Asp 
    13745                 13750                 13755             


Gln Thr   Val Thr Glu Phe Asp   Asp Ala Val Phe Ser   Cys Gln Leu 
    13760                 13765                 13770             


Ser Arg   Glu Lys Ala Asn Val   Lys Trp Tyr Arg Asn   Gly Arg Glu 
    13775                 13780                 13785             


Ile Lys   Glu Gly Lys Lys Tyr   Lys Phe Glu Lys Asp   Gly Ser Ile 
    13790                 13795                 13800             


His Arg   Leu Ile Ile Lys Asp   Cys Arg Leu Asp Asp   Glu Cys Glu 
    13805                 13810                 13815             


Tyr Ala   Cys Gly Val Glu Asp   Arg Lys Ser Arg Ala   Arg Leu Phe 
    13820                 13825                 13830             


Val Glu   Glu Ile Pro Val Glu   Ile Ile Arg Pro Pro   Gln Asp Ile 
    13835                 13840                 13845             


Leu Glu   Ala Pro Gly Ala Asp   Val Val Phe Leu Ala   Glu Leu Asn 
    13850                 13855                 13860             


Lys Asp   Lys Val Glu Val Gln   Trp Leu Arg Asn Asn   Met Val Val 
    13865                 13870                 13875             


Val Gln   Gly Asp Lys His Gln   Met Met Ser Glu Gly   Lys Ile His 
    13880                 13885                 13890             


Arg Leu   Gln Ile Cys Asp Ile   Lys Pro Arg Asp Gln   Gly Glu Tyr 
    13895                 13900                 13905             


Arg Phe   Ile Ala Lys Asp Lys   Glu Ala Arg Ala Lys   Leu Glu Leu 
    13910                 13915                 13920             


Ala Ala   Ala Pro Lys Ile Lys   Thr Ala Asp Gln Asp   Leu Val Val 
    13925                 13930                 13935             


Asp Val   Gly Lys Pro Leu Thr   Met Val Val Pro Tyr   Asp Ala Tyr 
    13940                 13945                 13950             


Pro Lys   Ala Glu Ala Glu Trp   Phe Lys Glu Asn Glu   Pro Leu Ser 
    13955                 13960                 13965             


Thr Lys   Thr Ile Asp Thr Thr   Ala Glu Gln Thr Ser   Phe Arg Ile 
    13970                 13975                 13980             


Leu Glu   Ala Lys Lys Gly Asp   Lys Gly Arg Tyr Lys   Ile Val Leu 
    13985                 13990                 13995             


Gln Asn   Lys His Gly Lys Ala   Glu Gly Phe Ile Asn   Leu Lys Val 
    14000                 14005                 14010             


Ile Asp   Val Pro Gly Pro Val   Arg Asn Leu Glu Val   Thr Glu Thr 
    14015                 14020                 14025             


Phe Asp   Gly Glu Val Ser Leu   Ala Trp Glu Glu Pro   Leu Thr Asp 
    14030                 14035                 14040             


Gly Gly   Ser Lys Ile Ile Gly   Tyr Val Val Glu Arg   Arg Asp Ile 
    14045                 14050                 14055             


Lys Arg   Lys Thr Trp Val Leu   Ala Thr Asp Arg Ala   Glu Ser Cys 
    14060                 14065                 14070             


Glu Phe   Thr Val Thr Gly Leu   Gln Lys Gly Gly Val   Glu Tyr Leu 
    14075                 14080                 14085             


Phe Arg   Val Ser Ala Arg Asn   Arg Val Gly Thr Gly   Glu Pro Val 
    14090                 14095                 14100             


Glu Thr   Asp Asn Pro Val Glu   Ala Arg Ser Lys Tyr   Asp Val Pro 
    14105                 14110                 14115             


Gly Pro   Pro Leu Asn Val Thr   Ile Thr Asp Val Asn   Arg Phe Gly 
    14120                 14125                 14130             


Val Ser   Leu Thr Trp Glu Pro   Pro Glu Tyr Asp Gly   Gly Ala Glu 
    14135                 14140                 14145             


Ile Thr   Asn Tyr Val Ile Glu   Leu Arg Asp Lys Thr   Ser Ile Arg 
    14150                 14155                 14160             


Trp Asp   Thr Ala Met Thr Val   Arg Ala Glu Asp Leu   Ser Ala Thr 
    14165                 14170                 14175             


Val Thr   Asp Val Val Glu Gly   Gln Glu Tyr Ser Phe   Arg Val Arg 
    14180                 14185                 14190             


Ala Gln   Asn Arg Ile Gly Val   Gly Lys Pro Ser Ala   Ala Thr Pro 
    14195                 14200                 14205             


Phe Val   Lys Val Ala Asp Pro   Ile Glu Arg Pro Ser   Pro Pro Val 
    14210                 14215                 14220             


Asn Leu   Thr Ser Ser Asp Gln   Thr Gln Ser Ser Val   Gln Leu Lys 
    14225                 14230                 14235             


Trp Glu   Pro Pro Leu Lys Asp   Gly Gly Ser Pro Ile   Leu Gly Tyr 
    14240                 14245                 14250             


Ile Ile   Glu Arg Cys Glu Glu   Gly Lys Asp Asn Trp   Ile Arg Cys 
    14255                 14260                 14265             


Asn Met   Lys Leu Val Pro Glu   Leu Thr Tyr Lys Val   Thr Gly Leu 
    14270                 14275                 14280             


Glu Lys   Gly Asn Lys Tyr Leu   Tyr Arg Val Ser Ala   Glu Asn Lys 
    14285                 14290                 14295             


Ala Gly   Val Ser Asp Pro Ser   Glu Ile Leu Gly Pro   Leu Thr Ala 
    14300                 14305                 14310             


Asp Asp   Ala Phe Val Glu Pro   Thr Met Asp Leu Ser   Ala Phe Lys 
    14315                 14320                 14325             


Asp Gly   Leu Glu Val Ile Val   Pro Asn Pro Ile Thr   Ile Leu Val 
    14330                 14335                 14340             


Pro Ser   Thr Gly Tyr Pro Arg   Pro Thr Ala Thr Trp   Cys Phe Gly 
    14345                 14350                 14355             


Asp Lys   Val Leu Glu Thr Gly   Asp Arg Val Lys Met   Lys Thr Leu 
    14360                 14365                 14370             


Ser Ala   Tyr Ala Glu Leu Val   Ile Ser Pro Ser Glu   Arg Ser Asp 
    14375                 14380                 14385             


Lys Gly   Ile Tyr Thr Leu Lys   Leu Glu Asn Arg Val   Lys Thr Ile 
    14390                 14395                 14400             


Ser Gly   Glu Ile Asp Val Asn   Val Ile Ala Arg Pro   Ser Ala Pro 
    14405                 14410                 14415             


Lys Glu   Leu Lys Phe Gly Asp   Ile Thr Lys Asp Ser   Val His Leu 
    14420                 14425                 14430             


Thr Trp   Glu Pro Pro Asp Asp   Asp Gly Gly Ser Pro   Leu Thr Gly 
    14435                 14440                 14445             


Tyr Val   Val Glu Lys Arg Glu   Val Ser Arg Lys Thr   Trp Thr Lys 
    14450                 14455                 14460             


Val Met   Asp Phe Val Thr Asp   Leu Glu Phe Thr Val   Pro Asp Leu 
    14465                 14470                 14475             


Val Gln   Gly Lys Glu Tyr Leu   Phe Lys Val Cys Ala   Arg Asn Lys 
    14480                 14485                 14490             


Cys Gly   Pro Gly Glu Pro Ala   Tyr Val Asp Glu Pro   Val Asn Met 
    14495                 14500                 14505             


Ser Thr   Pro Ala Thr Val Pro   Asp Pro Pro Glu Asn   Val Lys Trp 
    14510                 14515                 14520             


Arg Asp   Arg Thr Ala Asn Ser   Ile Phe Leu Thr Trp   Asp Pro Pro 
    14525                 14530                 14535             


Lys Asn   Asp Gly Gly Ser Arg   Ile Lys Gly Tyr Ile   Val Glu Arg 
    14540                 14545                 14550             


Cys Pro   Arg Gly Ser Asp Lys   Trp Val Ala Cys Gly   Glu Pro Val 
    14555                 14560                 14565             


Ala Glu   Thr Lys Met Glu Val   Thr Gly Leu Glu Glu   Gly Lys Trp 
    14570                 14575                 14580             


Tyr Ala   Tyr Arg Val Lys Ala   Leu Asn Arg Gln Gly   Ala Ser Lys 
    14585                 14590                 14595             


Pro Ser   Arg Pro Thr Glu Glu   Ile Gln Ala Val Asp   Thr Gln Glu 
    14600                 14605                 14610             


Ala Pro   Glu Ile Phe Leu Asp   Val Lys Leu Leu Ala   Gly Leu Thr 
    14615                 14620                 14625             


Val Lys   Ala Gly Thr Lys Ile   Glu Leu Pro Ala Thr   Val Thr Gly 
    14630                 14635                 14640             


Lys Pro   Glu Pro Lys Ile Thr   Trp Thr Lys Ala Asp   Met Ile Leu 
    14645                 14650                 14655             


Lys Gln   Asp Lys Arg Ile Thr   Ile Glu Asn Val Pro   Lys Lys Ser 
    14660                 14665                 14670             


Thr Val   Thr Ile Val Asp Ser   Lys Arg Ser Asp Thr   Gly Thr Tyr 
    14675                 14680                 14685             


Ile Ile   Glu Ala Val Asn Val   Cys Gly Arg Ala Thr   Ala Val Val 
    14690                 14695                 14700             


Glu Val   Asn Val Leu Asp Lys   Pro Gly Pro Pro Ala   Ala Phe Asp 
    14705                 14710                 14715             


Ile Thr   Asp Val Thr Asn Glu   Ser Cys Leu Leu Thr   Trp Asn Pro 
    14720                 14725                 14730             


Pro Arg   Asp Asp Gly Gly Ser   Lys Ile Thr Asn Tyr   Val Val Glu 
    14735                 14740                 14745             


Arg Arg   Ala Thr Asp Ser Glu   Val Trp His Lys Leu   Ser Ser Thr 
    14750                 14755                 14760             


Val Lys   Asp Thr Asn Phe Lys   Ala Thr Lys Leu Ile   Pro Asn Lys 
    14765                 14770                 14775             


Glu Tyr   Ile Phe Arg Val Ala   Ala Glu Asn Met Tyr   Gly Val Gly 
    14780                 14785                 14790             


Glu Pro   Val Gln Ala Ser Pro   Ile Thr Ala Lys Tyr   Gln Phe Asp 
    14795                 14800                 14805             


Pro Pro   Gly Pro Pro Thr Arg   Leu Glu Pro Ser Asp   Ile Thr Lys 
    14810                 14815                 14820             


Asp Ala   Val Thr Leu Thr Trp   Cys Glu Pro Asp Asp   Asp Gly Gly 
    14825                 14830                 14835             


Ser Pro   Ile Thr Gly Tyr Trp   Val Glu Arg Leu Asp   Pro Asp Thr 
    14840                 14845                 14850             


Asp Lys   Trp Val Arg Cys Asn   Lys Met Pro Val Lys   Asp Thr Thr 
    14855                 14860                 14865             


Tyr Arg   Val Lys Gly Leu Thr   Asn Lys Lys Lys Tyr   Arg Phe Arg 
    14870                 14875                 14880             


Val Leu   Ala Glu Asn Leu Ala   Gly Pro Gly Lys Pro   Ser Lys Ser 
    14885                 14890                 14895             


Thr Glu   Pro Ile Leu Ile Lys   Asp Pro Ile Asp Pro   Pro Trp Pro 
    14900                 14905                 14910             


Pro Gly   Lys Pro Thr Val Lys   Asp Val Gly Lys Thr   Ser Val Arg 
    14915                 14920                 14925             


Leu Asn   Trp Thr Lys Pro Glu   His Asp Gly Gly Ala   Lys Ile Glu 
    14930                 14935                 14940             


Ser Tyr   Val Ile Glu Met Leu   Lys Thr Gly Thr Asp   Glu Trp Val 
    14945                 14950                 14955             


Arg Val   Ala Glu Gly Val Pro   Thr Thr Gln His Leu   Leu Pro Gly 
    14960                 14965                 14970             


Leu Met   Glu Gly Gln Glu Tyr   Ser Phe Arg Val Arg   Ala Val Asn 
    14975                 14980                 14985             


Lys Ala   Gly Glu Ser Glu Pro   Ser Glu Pro Ser Asp   Pro Val Leu 
    14990                 14995                 15000             


Cys Arg   Glu Lys Leu Tyr Pro   Pro Ser Pro Pro Arg   Trp Leu Glu 
    15005                 15010                 15015             


Val Ile   Asn Ile Thr Lys Asn   Thr Ala Asp Leu Lys   Trp Thr Val 
    15020                 15025                 15030             


Pro Glu   Lys Asp Gly Gly Ser   Pro Ile Thr Asn Tyr   Ile Val Glu 
    15035                 15040                 15045             


Lys Arg   Asp Val Arg Arg Lys   Gly Trp Gln Thr Val   Asp Thr Thr 
    15050                 15055                 15060             


Val Lys   Asp Thr Lys Cys Thr   Val Thr Pro Leu Thr   Glu Gly Ser 
    15065                 15070                 15075             


Leu Tyr   Val Phe Arg Val Ala   Ala Glu Asn Ala Ile   Gly Gln Ser 
    15080                 15085                 15090             


Asp Tyr   Thr Glu Ile Glu Asp   Ser Val Leu Ala Lys   Asp Thr Phe 
    15095                 15100                 15105             


Thr Thr   Pro Gly Pro Pro Tyr   Ala Leu Ala Val Val   Asp Val Thr 
    15110                 15115                 15120             


Lys Arg   His Val Asp Leu Lys   Trp Glu Pro Pro Lys   Asn Asp Gly 
    15125                 15130                 15135             


Gly Arg   Pro Ile Gln Arg Tyr   Val Ile Glu Lys Lys   Glu Arg Leu 
    15140                 15145                 15150             


Gly Thr   Arg Trp Val Lys Ala   Gly Lys Thr Ala Gly   Pro Asp Cys 
    15155                 15160                 15165             


Asn Phe   Arg Val Thr Asp Val   Ile Glu Gly Thr Glu   Val Gln Phe 
    15170                 15175                 15180             


Gln Val   Arg Ala Glu Asn Glu   Ala Gly Val Gly His   Pro Ser Glu 
    15185                 15190                 15195             


Pro Thr   Glu Ile Leu Ser Ile   Glu Asp Pro Thr Ser   Pro Pro Ser 
    15200                 15205                 15210             


Pro Pro   Leu Asp Leu His Val   Thr Asp Ala Gly Arg   Lys His Ile 
    15215                 15220                 15225             


Ala Ile   Ala Trp Lys Pro Pro   Glu Lys Asn Gly Gly   Ser Pro Ile 
    15230                 15235                 15240             


Ile Gly   Tyr His Val Glu Met   Cys Pro Val Gly Thr   Glu Lys Trp 
    15245                 15250                 15255             


Met Arg   Val Asn Ser Arg Pro   Ile Lys Asp Leu Lys   Phe Lys Val 
    15260                 15265                 15270             


Glu Glu   Gly Val Val Pro Asp   Lys Glu Tyr Val Leu   Arg Val Arg 
    15275                 15280                 15285             


Ala Val   Asn Ala Ile Gly Val   Ser Glu Pro Ser Glu   Ile Ser Glu 
    15290                 15295                 15300             


Asn Val   Val Ala Lys Asp Pro   Asp Cys Lys Pro Thr   Ile Asp Leu 
    15305                 15310                 15315             


Glu Thr   His Asp Ile Ile Val   Ile Glu Gly Glu Lys   Leu Ser Ile 
    15320                 15325                 15330             


Pro Val   Pro Phe Arg Ala Val   Pro Val Pro Thr Val   Ser Trp His 
    15335                 15340                 15345             


Lys Asp   Gly Lys Glu Val Lys   Ala Ser Asp Arg Leu   Thr Met Lys 
    15350                 15355                 15360             


Asn Asp   His Ile Ser Ala His   Leu Glu Val Pro Lys   Ser Val Arg 
    15365                 15370                 15375             


Ala Asp   Ala Gly Ile Tyr Thr   Ile Thr Leu Glu Asn   Lys Leu Gly 
    15380                 15385                 15390             


Ser Ala   Thr Ala Ser Ile Asn   Val Lys Val Ile Gly   Leu Pro Gly 
    15395                 15400                 15405             


Pro Cys   Lys Asp Ile Lys Ala   Ser Asp Ile Thr Lys   Ser Ser Cys 
    15410                 15415                 15420             


Lys Leu   Thr Trp Glu Pro Pro   Glu Phe Asp Gly Gly   Thr Pro Ile 
    15425                 15430                 15435             


Leu His   Tyr Val Leu Glu Arg   Arg Glu Ala Gly Arg   Arg Thr Tyr 
    15440                 15445                 15450             


Ile Pro   Val Met Ser Gly Glu   Asn Lys Leu Ser Trp   Thr Val Lys 
    15455                 15460                 15465             


Asp Leu   Ile Pro Asn Gly Glu   Tyr Phe Phe Arg Val   Lys Ala Val 
    15470                 15475                 15480             


Asn Lys   Val Gly Gly Gly Glu   Tyr Ile Glu Leu Lys   Asn Pro Val 
    15485                 15490                 15495             


Ile Ala   Gln Asp Pro Lys Gln   Pro Pro Asp Pro Pro   Val Asp Val 
    15500                 15505                 15510             


Glu Val   His Asn Pro Thr Ala   Glu Ala Met Thr Ile   Thr Trp Lys 
    15515                 15520                 15525             


Pro Pro   Leu Tyr Asp Gly Gly   Ser Lys Ile Met Gly   Tyr Ile Ile 
    15530                 15535                 15540             


Glu Lys   Ile Ala Lys Gly Glu   Glu Arg Trp Lys Arg   Cys Asn Glu 
    15545                 15550                 15555             


His Leu   Val Pro Ile Leu Thr   Tyr Thr Ala Lys Gly   Leu Glu Glu 
    15560                 15565                 15570             


Gly Lys   Glu Tyr Gln Phe Arg   Val Arg Ala Glu Asn   Ala Ala Gly 
    15575                 15580                 15585             


Ile Ser   Glu Pro Ser Arg Ala   Thr Pro Pro Thr Lys   Ala Val Asp 
    15590                 15595                 15600             


Pro Ile   Asp Ala Pro Lys Val   Ile Leu Arg Thr Ser   Leu Glu Val 
    15605                 15610                 15615             


Lys Arg   Gly Asp Glu Ile Ala   Leu Asp Ala Ser Ile   Ser Gly Ser 
    15620                 15625                 15630             


Pro Tyr   Pro Thr Ile Thr Trp   Ile Lys Asp Glu Asn   Val Ile Val 
    15635                 15640                 15645             


Pro Glu   Glu Ile Lys Lys Arg   Ala Ala Pro Leu Val   Arg Arg Arg 
    15650                 15655                 15660             


Lys Gly   Glu Val Gln Glu Glu   Glu Pro Phe Val Leu   Pro Leu Thr 
    15665                 15670                 15675             


Gln Arg   Leu Ser Ile Asp Asn   Ser Lys Lys Gly Glu   Ser Gln Leu 
    15680                 15685                 15690             


Arg Val   Arg Asp Ser Leu Arg   Pro Asp His Gly Leu   Tyr Met Ile 
    15695                 15700                 15705             


Lys Val   Glu Asn Asp His Gly   Ile Ala Lys Ala Pro   Cys Thr Val 
    15710                 15715                 15720             


Ser Val   Leu Asp Thr Pro Gly   Pro Pro Ile Asn Phe   Val Phe Glu 
    15725                 15730                 15735             


Asp Ile   Arg Lys Thr Ser Val   Leu Cys Lys Trp Glu   Pro Pro Leu 
    15740                 15745                 15750             


Asp Asp   Gly Gly Ser Glu Ile   Ile Asn Tyr Thr Leu   Glu Lys Lys 
    15755                 15760                 15765             


Asp Lys   Thr Lys Pro Asp Ser   Glu Trp Ile Val Val   Thr Ser Thr 
    15770                 15775                 15780             


Leu Arg   His Cys Lys Tyr Ser   Val Thr Lys Leu Ile   Glu Gly Lys 
    15785                 15790                 15795             


Glu Tyr   Leu Phe Arg Val Arg   Ala Glu Asn Arg Phe   Gly Pro Gly 
    15800                 15805                 15810             


Pro Pro   Cys Val Ser Lys Pro   Leu Val Ala Lys Asp   Pro Phe Gly 
    15815                 15820                 15825             


Pro Pro   Asp Ala Pro Asp Lys   Pro Ile Val Glu Asp   Val Thr Ser 
    15830                 15835                 15840             


Asn Ser   Met Leu Val Lys Trp   Asn Glu Pro Lys Asp   Asn Gly Ser 
    15845                 15850                 15855             


Pro Ile   Leu Gly Tyr Trp Leu   Glu Lys Arg Glu Val   Asn Ser Thr 
    15860                 15865                 15870             


His Trp   Ser Arg Val Asn Lys   Ser Leu Leu Asn Ala   Leu Lys Ala 
    15875                 15880                 15885             


Asn Val   Asp Gly Leu Leu Glu   Gly Leu Thr Tyr Val   Phe Arg Val 
    15890                 15895                 15900             


Cys Ala   Glu Asn Ala Ala Gly   Pro Gly Lys Phe Ser   Pro Pro Ser 
    15905                 15910                 15915             


Asp Pro   Lys Thr Ala His Asp   Pro Ile Ser Pro Pro   Gly Pro Pro 
    15920                 15925                 15930             


Ile Pro   Arg Val Thr Asp Thr   Ser Ser Thr Thr Ile   Glu Leu Glu 
    15935                 15940                 15945             


Trp Glu   Pro Pro Ala Phe Asn   Gly Gly Gly Glu Ile   Val Gly Tyr 
    15950                 15955                 15960             


Phe Val   Asp Lys Gln Leu Val   Gly Thr Asn Glu Trp   Ser Arg Cys 
    15965                 15970                 15975             


Thr Glu   Lys Met Ile Lys Val   Arg Gln Tyr Thr Val   Lys Glu Ile 
    15980                 15985                 15990             


Arg Glu   Gly Ala Asp Tyr Lys   Leu Arg Val Ser Ala   Val Asn Ala 
    15995                 16000                 16005             


Ala Gly   Glu Gly Pro Pro Gly   Glu Thr Gln Pro Val   Thr Val Ala 
    16010                 16015                 16020             


Glu Pro   Gln Glu Pro Pro Ala   Val Glu Leu Asp Val   Ser Val Lys 
    16025                 16030                 16035             


Gly Gly   Ile Gln Ile Met Ala   Gly Lys Thr Leu Arg   Ile Pro Ala 
    16040                 16045                 16050             


Val Val   Thr Gly Arg Pro Val   Pro Thr Lys Val Trp   Thr Lys Glu 
    16055                 16060                 16065             


Glu Gly   Glu Leu Asp Lys Asp   Arg Val Val Ile Asp   Asn Val Gly 
    16070                 16075                 16080             


Thr Lys   Ser Glu Leu Ile Ile   Lys Asp Ala Leu Arg   Lys Asp His 
    16085                 16090                 16095             


Gly Arg   Tyr Val Ile Thr Ala   Thr Asn Ser Cys Gly   Ser Lys Phe 
    16100                 16105                 16110             


Ala Ala   Ala Arg Val Glu Val   Phe Asp Val Pro Gly   Pro Val Leu 
    16115                 16120                 16125             


Asp Leu   Lys Pro Val Val Thr   Asn Arg Lys Met Cys   Leu Leu Asn 
    16130                 16135                 16140             


Trp Ser   Asp Pro Glu Asp Asp   Gly Gly Ser Glu Ile   Thr Gly Phe 
    16145                 16150                 16155             


Ile Ile   Glu Arg Lys Asp Ala   Lys Met His Thr Trp   Arg Gln Pro 
    16160                 16165                 16170             


Ile Glu   Thr Glu Arg Ser Lys   Cys Asp Ile Thr Gly   Leu Leu Glu 
    16175                 16180                 16185             


Gly Gln   Glu Tyr Lys Phe Arg   Val Ile Ala Lys Asn   Lys Phe Gly 
    16190                 16195                 16200             


Cys Gly   Pro Pro Val Glu Ile   Gly Pro Ile Leu Ala   Val Asp Pro 
    16205                 16210                 16215             


Leu Gly   Pro Pro Thr Ser Pro   Glu Arg Leu Thr Tyr   Thr Glu Arg 
    16220                 16225                 16230             


Thr Lys   Ser Thr Ile Thr Leu   Asp Trp Lys Glu Pro   Arg Ser Asn 
    16235                 16240                 16245             


Gly Gly   Ser Pro Ile Gln Gly   Tyr Ile Ile Glu Lys   Arg Arg His 
    16250                 16255                 16260             


Asp Lys   Pro Asp Phe Glu Arg   Val Asn Lys Arg Leu   Cys Pro Thr 
    16265                 16270                 16275             


Thr Ser   Phe Leu Val Glu Asn   Leu Asp Glu His Gln   Met Tyr Glu 
    16280                 16285                 16290             


Phe Arg   Val Lys Ala Val Asn   Glu Ile Gly Glu Ser   Glu Pro Ser 
    16295                 16300                 16305             


Leu Pro   Leu Asn Val Val Ile   Gln Asp Asp Glu Val   Pro Pro Thr 
    16310                 16315                 16320             


Ile Lys   Leu Arg Leu Ser Val   Arg Gly Asp Thr Ile   Lys Val Lys 
    16325                 16330                 16335             


Ala Gly   Glu Pro Val His Ile   Pro Ala Asp Val Thr   Gly Leu Pro 
    16340                 16345                 16350             


Met Pro   Lys Ile Glu Trp Ser   Lys Asn Glu Thr Val   Ile Glu Lys 
    16355                 16360                 16365             


Pro Thr   Asp Ala Leu Gln Ile   Thr Lys Glu Glu Val   Ser Arg Ser 
    16370                 16375                 16380             


Glu Ala   Lys Thr Glu Leu Ser   Ile Pro Lys Ala Val   Arg Glu Asp 
    16385                 16390                 16395             


Lys Gly   Thr Tyr Thr Val Thr   Ala Ser Asn Arg Leu   Gly Ser Val 
    16400                 16405                 16410             


Phe Arg   Asn Val His Val Glu   Val Tyr Asp Arg Pro   Ser Pro Pro 
    16415                 16420                 16425             


Arg Asn   Leu Ala Val Thr Asp   Ile Lys Ala Glu Ser   Cys Tyr Leu 
    16430                 16435                 16440             


Thr Trp   Asp Ala Pro Leu Asp   Asn Gly Gly Ser Glu   Ile Thr His 
    16445                 16450                 16455             


Tyr Val   Ile Asp Lys Arg Asp   Ala Ser Arg Lys Lys   Ala Glu Trp 
    16460                 16465                 16470             


Glu Glu   Val Thr Asn Thr Ala   Val Glu Lys Arg Tyr   Gly Ile Trp 
    16475                 16480                 16485             


Lys Leu   Ile Pro Asn Gly Gln   Tyr Glu Phe Arg Val   Arg Ala Val 
    16490                 16495                 16500             


Asn Lys   Tyr Gly Ile Ser Asp   Glu Cys Lys Ser Asp   Lys Val Val 
    16505                 16510                 16515             


Ile Gln   Asp Pro Tyr Arg Leu   Pro Gly Pro Pro Gly   Lys Pro Lys 
    16520                 16525                 16530             


Val Leu   Ala Arg Thr Lys Gly   Ser Met Leu Val Ser   Trp Thr Pro 
    16535                 16540                 16545             


Pro Leu   Asp Asn Gly Gly Ser   Pro Ile Thr Gly Tyr   Trp Leu Glu 
    16550                 16555                 16560             


Lys Arg   Glu Glu Gly Ser Pro   Tyr Trp Ser Arg Val   Ser Arg Ala 
    16565                 16570                 16575             


Pro Ile   Thr Lys Val Gly Leu   Lys Gly Val Glu Phe   Asn Val Pro 
    16580                 16585                 16590             


Arg Leu   Leu Glu Gly Val Lys   Tyr Gln Phe Arg Ala   Met Ala Ile 
    16595                 16600                 16605             


Asn Ala   Ala Gly Ile Gly Pro   Pro Ser Glu Pro Ser   Asp Pro Glu 
    16610                 16615                 16620             


Val Ala   Gly Asp Pro Ile Phe   Pro Pro Gly Pro Pro   Ser Cys Pro 
    16625                 16630                 16635             


Glu Val   Lys Asp Lys Thr Lys   Ser Ser Ile Ser Leu   Gly Trp Lys 
    16640                 16645                 16650             


Pro Pro   Ala Lys Asp Gly Gly   Ser Pro Ile Lys Gly   Tyr Ile Val 
    16655                 16660                 16665             


Glu Met   Gln Glu Glu Gly Thr   Thr Asp Trp Lys Arg   Val Asn Glu 
    16670                 16675                 16680             


Pro Asp   Lys Leu Ile Thr Thr   Cys Glu Cys Val Val   Pro Asn Leu 
    16685                 16690                 16695             


Lys Glu   Leu Arg Lys Tyr Arg   Phe Arg Val Lys Ala   Val Asn Glu 
    16700                 16705                 16710             


Ala Gly   Glu Ser Glu Pro Ser   Asp Thr Thr Gly Glu   Ile Pro Ala 
    16715                 16720                 16725             


Thr Asp   Ile Gln Glu Glu Pro   Glu Val Phe Ile Asp   Ile Gly Ala 
    16730                 16735                 16740             


Gln Asp   Cys Leu Val Cys Lys   Ala Gly Ser Gln Ile   Arg Ile Pro 
    16745                 16750                 16755             


Ala Val   Ile Lys Gly Arg Pro   Thr Pro Lys Ser Ser   Trp Glu Phe 
    16760                 16765                 16770             


Asp Gly   Lys Ala Lys Lys Ala   Met Lys Asp Gly Val   His Asp Ile 
    16775                 16780                 16785             


Pro Glu   Asp Ala Gln Leu Glu   Thr Ala Glu Asn Ser   Ser Val Ile 
    16790                 16795                 16800             


Ile Ile   Pro Glu Cys Lys Arg   Ser His Thr Gly Lys   Tyr Ser Ile 
    16805                 16810                 16815             


Thr Ala   Lys Asn Lys Ala Gly   Gln Lys Thr Ala Asn   Cys Arg Val 
    16820                 16825                 16830             


Lys Val   Met Asp Val Pro Gly   Pro Pro Lys Asp Leu   Lys Val Ser 
    16835                 16840                 16845             


Asp Ile   Thr Arg Gly Ser Cys   Arg Leu Ser Trp Lys   Met Pro Asp 
    16850                 16855                 16860             


Asp Asp   Gly Gly Asp Arg Ile   Lys Gly Tyr Val Ile   Glu Lys Arg 
    16865                 16870                 16875             


Thr Ile   Asp Gly Lys Ala Trp   Thr Lys Val Asn Pro   Asp Cys Gly 
    16880                 16885                 16890             


Ser Thr   Thr Phe Val Val Pro   Asp Leu Leu Ser Glu   Gln Gln Tyr 
    16895                 16900                 16905             


Phe Phe   Arg Val Arg Ala Glu   Asn Arg Phe Gly Ile   Gly Pro Pro 
    16910                 16915                 16920             


Val Glu   Thr Ile Gln Arg Thr   Thr Ala Arg Asp Pro   Ile Tyr Pro 
    16925                 16930                 16935             


Pro Asp   Pro Pro Ile Lys Leu   Lys Ile Gly Leu Ile   Thr Lys Asn 
    16940                 16945                 16950             


Thr Val   His Leu Ser Trp Lys   Pro Pro Lys Asn Asp   Gly Gly Ser 
    16955                 16960                 16965             


Pro Val   Thr His Tyr Ile Val   Glu Cys Leu Ala Trp   Asp Pro Thr 
    16970                 16975                 16980             


Gly Thr   Lys Lys Glu Ala Trp   Arg Gln Cys Asn Lys   Arg Asp Val 
    16985                 16990                 16995             


Glu Glu   Leu Gln Phe Thr Val   Glu Asp Leu Val Glu   Gly Gly Glu 
    17000                 17005                 17010             


Tyr Glu   Phe Arg Val Lys Ala   Val Asn Ala Ala Gly   Val Ser Lys 
    17015                 17020                 17025             


Pro Ser   Ala Thr Val Gly Pro   Cys Asp Cys Gln Arg   Pro Asp Met 
    17030                 17035                 17040             


Pro Pro   Ser Ile Asp Leu Lys   Glu Phe Met Glu Val   Glu Glu Gly 
    17045                 17050                 17055             


Thr Asn   Val Asn Ile Val Ala   Lys Ile Lys Gly Val   Pro Phe Pro 
    17060                 17065                 17070             


Thr Leu   Thr Trp Phe Lys Ala   Pro Pro Lys Lys Pro   Asp Asn Lys 
    17075                 17080                 17085             


Glu Pro   Val Leu Tyr Asp Thr   His Val Asn Lys Leu   Val Val Asp 
    17090                 17095                 17100             


Asp Thr   Cys Thr Leu Val Ile   Pro Gln Ser Arg Arg   Ser Asp Thr 
    17105                 17110                 17115             


Gly Leu   Tyr Thr Ile Thr Ala   Val Asn Asn Leu Gly   Thr Ala Ser 
    17120                 17125                 17130             


Lys Glu   Met Arg Leu Asn Val   Leu Gly Arg Pro Gly   Pro Pro Val 
    17135                 17140                 17145             


Gly Pro   Ile Lys Phe Glu Ser   Val Ser Ala Asp Gln   Met Thr Leu 
    17150                 17155                 17160             


Ser Trp   Phe Pro Pro Lys Asp   Asp Gly Gly Ser Lys   Ile Thr Asn 
    17165                 17170                 17175             


Tyr Val   Ile Glu Lys Arg Glu   Ala Asn Arg Lys Thr   Trp Val His 
    17180                 17185                 17190             


Val Ser   Ser Glu Pro Lys Glu   Cys Thr Tyr Thr Ile   Pro Lys Leu 
    17195                 17200                 17205             


Leu Glu   Gly His Glu Tyr Val   Phe Arg Ile Met Ala   Gln Asn Lys 
    17210                 17215                 17220             


Tyr Gly   Ile Gly Glu Pro Leu   Asp Ser Glu Pro Glu   Thr Ala Arg 
    17225                 17230                 17235             


Asn Leu   Phe Ser Val Pro Gly   Ala Pro Asp Lys Pro   Thr Val Ser 
    17240                 17245                 17250             


Ser Val   Thr Arg Asn Ser Met   Thr Val Asn Trp Glu   Glu Pro Glu 
    17255                 17260                 17265             


Tyr Asp   Gly Gly Ser Pro Val   Thr Gly Tyr Trp Leu   Glu Met Lys 
    17270                 17275                 17280             


Asp Thr   Thr Ser Lys Arg Trp   Lys Arg Val Asn Arg   Asp Pro Ile 
    17285                 17290                 17295             


Lys Ala   Met Thr Leu Gly Val   Ser Tyr Lys Val Thr   Gly Leu Ile 
    17300                 17305                 17310             


Glu Gly   Ser Asp Tyr Gln Phe   Arg Val Tyr Ala Ile   Asn Ala Ala 
    17315                 17320                 17325             


Gly Val   Gly Pro Ala Ser Leu   Pro Ser Asp Pro Ala   Thr Ala Arg 
    17330                 17335                 17340             


Asp Pro   Ile Ala Pro Pro Gly   Pro Pro Phe Pro Lys   Val Thr Asp 
    17345                 17350                 17355             


Trp Thr   Lys Ser Ser Ala Asp   Leu Glu Trp Ser Pro   Pro Leu Lys 
    17360                 17365                 17370             


Asp Gly   Gly Ser Lys Val Thr   Gly Tyr Ile Val Glu   Tyr Lys Glu 
    17375                 17380                 17385             


Glu Gly   Lys Glu Glu Trp Glu   Lys Gly Lys Asp Lys   Glu Val Arg 
    17390                 17395                 17400             


Gly Thr   Lys Leu Val Val Thr   Gly Leu Lys Glu Gly   Ala Phe Tyr 
    17405                 17410                 17415             


Lys Phe   Arg Val Ser Ala Val   Asn Ile Ala Gly Ile   Gly Glu Pro 
    17420                 17425                 17430             


Gly Glu   Val Thr Asp Val Ile   Glu Met Lys Asp Arg   Leu Val Ser 
    17435                 17440                 17445             


Pro Asp   Leu Gln Leu Asp Ala   Ser Val Arg Asp Arg   Ile Val Val 
    17450                 17455                 17460             


His Ala   Gly Gly Val Ile Arg   Ile Ile Ala Tyr Val   Ser Gly Lys 
    17465                 17470                 17475             


Pro Pro   Pro Thr Val Thr Trp   Asn Met Asn Glu Arg   Thr Leu Pro 
    17480                 17485                 17490             


Gln Glu   Ala Thr Ile Glu Thr   Thr Ala Ile Ser Ser   Ser Met Val 
    17495                 17500                 17505             


Ile Lys   Asn Cys Gln Arg Ser   His Gln Gly Val Tyr   Ser Leu Leu 
    17510                 17515                 17520             


Ala Lys   Asn Glu Ala Gly Glu   Arg Lys Lys Thr Ile   Ile Val Asp 
    17525                 17530                 17535             


Val Leu   Asp Val Pro Gly Pro   Val Gly Thr Pro Phe   Leu Ala His 
    17540                 17545                 17550             


Asn Leu   Thr Asn Glu Ser Cys   Lys Leu Thr Trp Phe   Ser Pro Glu 
    17555                 17560                 17565             


Asp Asp   Gly Gly Ser Pro Ile   Thr Asn Tyr Val Ile   Glu Lys Arg 
    17570                 17575                 17580             


Glu Ser   Asp Arg Arg Ala Trp   Thr Pro Val Thr Tyr   Thr Val Thr 
    17585                 17590                 17595             


Arg Gln   Asn Ala Thr Val Gln   Gly Leu Ile Gln Gly   Lys Ala Tyr 
    17600                 17605                 17610             


Phe Phe   Arg Ile Ala Ala Glu   Asn Ser Ile Gly Met   Gly Pro Phe 
    17615                 17620                 17625             


Val Glu   Thr Ser Glu Ala Leu   Val Ile Arg Glu Pro   Ile Thr Val 
    17630                 17635                 17640             


Pro Glu   Arg Pro Glu Asp Leu   Glu Val Lys Glu Val   Thr Lys Asn 
    17645                 17650                 17655             


Thr Val   Thr Leu Thr Trp Asn   Pro Pro Lys Tyr Asp   Gly Gly Ser 
    17660                 17665                 17670             


Glu Ile   Ile Asn Tyr Val Leu   Glu Ser Arg Leu Ile   Gly Thr Glu 
    17675                 17680                 17685             


Lys Phe   His Lys Val Thr Asn   Asp Asn Leu Leu Ser   Arg Lys Tyr 
    17690                 17695                 17700             


Thr Val   Lys Gly Leu Lys Glu   Gly Asp Thr Tyr Glu   Tyr Arg Val 
    17705                 17710                 17715             


Ser Ala   Val Asn Ile Val Gly   Gln Gly Lys Pro Ser   Phe Cys Thr 
    17720                 17725                 17730             


Lys Pro   Ile Thr Cys Lys Asp   Glu Leu Ala Pro Pro   Thr Leu His 
    17735                 17740                 17745             


Leu Asp   Phe Arg Asp Lys Leu   Thr Ile Arg Val Gly   Glu Ala Phe 
    17750                 17755                 17760             


Ala Leu   Thr Gly Arg Tyr Ser   Gly Lys Pro Lys Pro   Lys Val Ser 
    17765                 17770                 17775             


Trp Phe   Lys Asp Glu Ala Asp   Val Leu Glu Asp Asp   Arg Thr His 
    17780                 17785                 17790             


Ile Lys   Thr Thr Pro Ala Thr   Leu Ala Leu Glu Lys   Ile Lys Ala 
    17795                 17800                 17805             


Lys Arg   Ser Asp Ser Gly Lys   Tyr Cys Val Val Val   Glu Asn Ser 
    17810                 17815                 17820             


Thr Gly   Ser Arg Lys Gly Phe   Cys Gln Val Asn Val   Val Asp Arg 
    17825                 17830                 17835             


Pro Gly   Pro Pro Val Gly Pro   Val Ser Phe Asp Glu   Val Thr Lys 
    17840                 17845                 17850             


Asp Tyr   Met Val Ile Ser Trp   Lys Pro Pro Leu Asp   Asp Gly Gly 
    17855                 17860                 17865             


Ser Lys   Ile Thr Asn Tyr Ile   Ile Glu Lys Lys Glu   Val Gly Lys 
    17870                 17875                 17880             


Asp Val   Trp Met Pro Val Thr   Ser Ala Ser Ala Lys   Thr Thr Cys 
    17885                 17890                 17895             


Lys Val   Ser Lys Leu Leu Glu   Gly Lys Asp Tyr Ile   Phe Arg Ile 
    17900                 17905                 17910             


His Ala   Glu Asn Leu Tyr Gly   Ile Ser Asp Pro Leu   Val Ser Asp 
    17915                 17920                 17925             


Ser Met   Lys Ala Lys Asp Arg   Phe Arg Val Pro Asp   Ala Pro Asp 
    17930                 17935                 17940             


Gln Pro   Ile Val Thr Glu Val   Thr Lys Asp Ser Ala   Leu Val Thr 
    17945                 17950                 17955             


Trp Asn   Lys Pro His Asp Gly   Gly Lys Pro Ile Thr   Asn Tyr Ile 
    17960                 17965                 17970             


Leu Glu   Lys Arg Glu Thr Met   Ser Lys Arg Trp Ala   Arg Val Thr 
    17975                 17980                 17985             


Lys Asp   Pro Ile His Pro Tyr   Thr Lys Phe Arg Val   Pro Asp Leu 
    17990                 17995                 18000             


Leu Glu   Gly Cys Gln Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Glu 
    18005                 18010                 18015             


Ile Gly   Ile Gly Asp Pro Ser   Pro Pro Ser Lys Pro   Val Phe Ala 
    18020                 18025                 18030             


Lys Asp   Pro Ile Ala Lys Pro   Ser Pro Pro Val Asn   Pro Glu Ala 
    18035                 18040                 18045             


Ile Asp   Thr Thr Cys Asn Ser   Val Asp Leu Thr Trp   Gln Pro Pro 
    18050                 18055                 18060             


Arg His   Asp Gly Gly Ser Lys   Ile Leu Gly Tyr Ile   Val Glu Tyr 
    18065                 18070                 18075             


Gln Lys   Val Gly Asp Glu Glu   Trp Arg Arg Ala Asn   His Thr Pro 
    18080                 18085                 18090             


Glu Ser   Cys Pro Glu Thr Lys   Tyr Lys Val Thr Gly   Leu Arg Asp 
    18095                 18100                 18105             


Gly Gln   Thr Tyr Lys Phe Arg   Val Leu Ala Val Asn   Ala Ala Gly 
    18110                 18115                 18120             


Glu Ser   Asp Pro Ala His Val   Pro Glu Pro Val Leu   Val Lys Asp 
    18125                 18130                 18135             


Arg Leu   Glu Pro Pro Glu Leu   Ile Leu Asp Ala Asn   Met Ala Arg 
    18140                 18145                 18150             


Glu Gln   His Ile Lys Val Gly   Asp Thr Leu Arg Leu   Ser Ala Ile 
    18155                 18160                 18165             


Ile Lys   Gly Val Pro Phe Pro   Lys Val Thr Trp Lys   Lys Glu Asp 
    18170                 18175                 18180             


Arg Asp   Ala Pro Thr Lys Ala   Arg Ile Asp Val Thr   Pro Val Gly 
    18185                 18190                 18195             


Ser Lys   Leu Glu Ile Arg Asn   Ala Ala His Glu Asp   Gly Gly Ile 
    18200                 18205                 18210             


Tyr Ser   Leu Thr Val Glu Asn   Pro Ala Gly Ser Lys   Thr Val Ser 
    18215                 18220                 18225             


Val Lys   Val Leu Val Leu Asp   Lys Pro Gly Pro Pro   Arg Asp Leu 
    18230                 18235                 18240             


Glu Val   Ser Glu Ile Arg Lys   Asp Ser Cys Tyr Leu   Thr Trp Lys 
    18245                 18250                 18255             


Glu Pro   Leu Asp Asp Gly Gly   Ser Val Ile Thr Asn   Tyr Val Val 
    18260                 18265                 18270             


Glu Arg   Arg Asp Val Ala Ser   Ala Gln Trp Ser Pro   Leu Ser Ala 
    18275                 18280                 18285             


Thr Ser   Lys Lys Lys Ser His   Phe Ala Lys His Leu   Asn Glu Gly 
    18290                 18295                 18300             


Asn Gln   Tyr Leu Phe Arg Val   Ala Ala Glu Asn Gln   Tyr Gly Arg 
    18305                 18310                 18315             


Gly Pro   Phe Val Glu Thr Pro   Lys Pro Ile Lys Ala   Leu Asp Pro 
    18320                 18325                 18330             


Leu His   Pro Pro Gly Pro Pro   Lys Asp Leu His His   Val Asp Val 
    18335                 18340                 18345             


Asp Lys   Thr Glu Val Ser Leu   Val Trp Asn Lys Pro   Asp Arg Asp 
    18350                 18355                 18360             


Gly Gly   Ser Pro Ile Thr Gly   Tyr Leu Val Glu Tyr   Gln Glu Glu 
    18365                 18370                 18375             


Gly Thr   Gln Asp Trp Ile Lys   Phe Lys Thr Val Thr   Asn Leu Glu 
    18380                 18385                 18390             


Cys Val   Val Thr Gly Leu Gln   Gln Gly Lys Thr Tyr   Arg Phe Arg 
    18395                 18400                 18405             


Val Lys   Ala Glu Asn Ile Val   Gly Leu Gly Leu Pro   Asp Thr Thr 
    18410                 18415                 18420             


Ile Pro   Ile Glu Cys Gln Glu   Lys Leu Val Pro Pro   Ser Val Glu 
    18425                 18430                 18435             


Leu Asp   Val Lys Leu Ile Glu   Gly Leu Val Val Lys   Ala Gly Thr 
    18440                 18445                 18450             


Thr Val   Arg Phe Pro Ala Ile   Ile Arg Gly Val Pro   Val Pro Thr 
    18455                 18460                 18465             


Ala Lys   Trp Thr Thr Asp Gly   Ser Glu Ile Lys Thr   Asp Glu His 
    18470                 18475                 18480             


Tyr Thr   Val Glu Thr Asp Asn   Phe Ser Ser Val Leu   Thr Ile Lys 
    18485                 18490                 18495             


Asn Cys   Leu Arg Arg Asp Thr   Gly Glu Tyr Gln Ile   Thr Val Ser 
    18500                 18505                 18510             


Asn Ala   Ala Gly Ser Lys Thr   Val Ala Val His Leu   Thr Val Leu 
    18515                 18520                 18525             


Asp Val   Pro Gly Pro Pro Thr   Gly Pro Ile Asn Ile   Leu Asp Val 
    18530                 18535                 18540             


Thr Pro   Glu His Met Thr Ile   Ser Trp Gln Pro Pro   Lys Asp Asp 
    18545                 18550                 18555             


Gly Gly   Ser Pro Val Ile Asn   Tyr Ile Val Glu Lys   Gln Asp Thr 
    18560                 18565                 18570             


Arg Lys   Asp Thr Trp Gly Val   Val Ser Ser Gly Ser   Ser Lys Thr 
    18575                 18580                 18585             


Lys Leu   Lys Ile Pro His Leu   Gln Lys Gly Cys Glu   Tyr Val Phe 
    18590                 18595                 18600             


Arg Val   Arg Ala Glu Asn Lys   Ile Gly Val Gly Pro   Pro Leu Asp 
    18605                 18610                 18615             


Ser Thr   Pro Thr Val Ala Lys   His Lys Phe Ser Pro   Pro Ser Pro 
    18620                 18625                 18630             


Pro Gly   Lys Pro Val Val Thr   Asp Ile Thr Glu Asn   Ala Ala Thr 
    18635                 18640                 18645             


Val Ser   Trp Thr Leu Pro Lys   Ser Asp Gly Gly Ser   Pro Ile Thr 
    18650                 18655                 18660             


Gly Tyr   Tyr Met Glu Arg Arg   Glu Val Thr Gly Lys   Trp Val Arg 
    18665                 18670                 18675             


Val Asn   Lys Thr Pro Ile Ala   Asp Leu Lys Phe Arg   Val Thr Gly 
    18680                 18685                 18690             


Leu Tyr   Glu Gly Asn Thr Tyr   Glu Phe Arg Val Phe   Ala Glu Asn 
    18695                 18700                 18705             


Leu Ala   Gly Leu Ser Lys Pro   Ser Pro Ser Ser Asp   Pro Ile Lys 
    18710                 18715                 18720             


Ala Cys   Arg Pro Ile Lys Pro   Pro Gly Pro Pro Ile   Asn Pro Lys 
    18725                 18730                 18735             


Leu Lys   Asp Lys Ser Arg Glu   Thr Ala Asp Leu Val   Trp Thr Lys 
    18740                 18745                 18750             


Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu Gly Tyr   Val Val Glu 
    18755                 18760                 18765             


Cys Gln   Lys Pro Gly Thr Ala   Gln Trp Asn Arg Ile   Asn Lys Asp 
    18770                 18775                 18780             


Glu Leu   Ile Arg Gln Cys Ala   Phe Arg Val Pro Gly   Leu Ile Glu 
    18785                 18790                 18795             


Gly Asn   Glu Tyr Arg Phe Arg   Ile Lys Ala Ala Asn   Ile Val Gly 
    18800                 18805                 18810             


Glu Gly   Glu Pro Arg Glu Leu   Ala Glu Ser Val Ile   Ala Lys Asp 
    18815                 18820                 18825             


Ile Leu   His Pro Pro Glu Val   Glu Leu Asp Val Thr   Cys Arg Asp 
    18830                 18835                 18840             


Val Ile   Thr Val Arg Val Gly   Gln Thr Ile Arg Ile   Leu Ala Arg 
    18845                 18850                 18855             


Val Lys   Gly Arg Pro Glu Pro   Asp Ile Thr Trp Thr   Lys Glu Gly 
    18860                 18865                 18870             


Lys Val   Leu Val Arg Glu Lys   Arg Val Asp Leu Ile   Gln Asp Leu 
    18875                 18880                 18885             


Pro Arg   Val Glu Leu Gln Ile   Lys Glu Ala Val Arg   Ala Asp His 
    18890                 18895                 18900             


Gly Lys   Tyr Ile Ile Ser Ala   Lys Asn Ser Ser Gly   His Ala Gln 
    18905                 18910                 18915             


Gly Ser   Ala Ile Val Asn Val   Leu Asp Arg Pro Gly   Pro Cys Gln 
    18920                 18925                 18930             


Asn Leu   Lys Val Thr Asn Val   Thr Lys Glu Asn Cys   Thr Ile Ser 
    18935                 18940                 18945             


Trp Glu   Asn Pro Leu Asp Asn   Gly Gly Ser Glu Ile   Thr Asn Phe 
    18950                 18955                 18960             


Ile Val   Glu Tyr Arg Lys Pro   Asn Gln Lys Gly Trp   Ser Ile Val 
    18965                 18970                 18975             


Ala Ser   Asp Val Thr Lys Arg   Leu Ile Lys Ala Asn   Leu Leu Ala 
    18980                 18985                 18990             


Asn Asn   Glu Tyr Tyr Phe Arg   Val Cys Ala Glu Asn   Lys Val Gly 
    18995                 19000                 19005             


Val Gly   Pro Thr Ile Glu Thr   Lys Thr Pro Ile Leu   Ala Ile Asn 
    19010                 19015                 19020             


Pro Ile   Asp Arg Pro Gly Glu   Pro Glu Asn Leu His   Ile Ala Asp 
    19025                 19030                 19035             


Lys Gly   Lys Thr Phe Val Tyr   Leu Lys Trp Arg Arg   Pro Asp Tyr 
    19040                 19045                 19050             


Asp Gly   Gly Ser Pro Asn Leu   Ser Tyr His Val Glu   Arg Arg Leu 
    19055                 19060                 19065             


Lys Gly   Ser Asp Asp Trp Glu   Arg Val His Lys Gly   Ser Ile Lys 
    19070                 19075                 19080             


Glu Thr   His Tyr Met Val Asp   Arg Cys Val Glu Asn   Gln Ile Tyr 
    19085                 19090                 19095             


Glu Phe   Arg Val Gln Thr Lys   Asn Glu Gly Gly Glu   Ser Asp Trp 
    19100                 19105                 19110             


Val Lys   Thr Glu Glu Val Val   Val Lys Glu Asp Leu   Gln Lys Pro 
    19115                 19120                 19125             


Val Leu   Asp Leu Lys Leu Ser   Gly Val Leu Thr Val   Lys Ala Gly 
    19130                 19135                 19140             


Asp Thr   Ile Arg Leu Glu Ala   Gly Val Arg Gly Lys   Pro Phe Pro 
    19145                 19150                 19155             


Glu Val   Ala Trp Thr Lys Asp   Lys Asp Ala Thr Asp   Leu Thr Arg 
    19160                 19165                 19170             


Ser Pro   Arg Val Lys Ile Asp   Thr Arg Ala Asp Ser   Ser Lys Phe 
    19175                 19180                 19185             


Ser Leu   Thr Lys Ala Lys Arg   Ser Asp Gly Gly Lys   Tyr Val Val 
    19190                 19195                 19200             


Thr Ala   Thr Asn Thr Ala Gly   Ser Phe Val Ala Tyr   Ala Thr Val 
    19205                 19210                 19215             


Asn Val   Leu Asp Lys Pro Gly   Pro Val Arg Asn Leu   Lys Ile Val 
    19220                 19225                 19230             


Asp Val   Ser Ser Asp Arg Cys   Thr Val Cys Trp Asp   Pro Pro Glu 
    19235                 19240                 19245             


Asp Asp   Gly Gly Cys Glu Ile   Gln Asn Tyr Ile Leu   Glu Lys Cys 
    19250                 19255                 19260             


Glu Thr   Lys Arg Met Val Trp   Ser Thr Tyr Ser Ala   Thr Val Leu 
    19265                 19270                 19275             


Thr Pro   Gly Thr Thr Val Thr   Arg Leu Ile Glu Gly   Asn Glu Tyr 
    19280                 19285                 19290             


Ile Phe   Arg Val Arg Ala Glu   Asn Lys Ile Gly Thr   Gly Pro Pro 
    19295                 19300                 19305             


Thr Glu   Ser Lys Pro Val Ile   Ala Lys Thr Lys Tyr   Asp Lys Pro 
    19310                 19315                 19320             


Gly Arg   Pro Asp Pro Pro Glu   Val Thr Lys Val Ser   Lys Glu Glu 
    19325                 19330                 19335             


Met Thr   Val Val Trp Asn Pro   Pro Glu Tyr Asp Gly   Gly Lys Ser 
    19340                 19345                 19350             


Ile Thr   Gly Tyr Phe Leu Glu   Lys Lys Glu Lys His   Ser Thr Arg 
    19355                 19360                 19365             


Trp Val   Pro Val Asn Lys Ser   Ala Ile Pro Glu Arg   Arg Met Lys 
    19370                 19375                 19380             


Val Gln   Asn Leu Leu Pro Asp   His Glu Tyr Gln Phe   Arg Val Lys 
    19385                 19390                 19395             


Ala Glu   Asn Glu Ile Gly Ile   Gly Glu Pro Ser Leu   Pro Ser Arg 
    19400                 19405                 19410             


Pro Val   Val Ala Lys Asp Pro   Ile Glu Pro Pro Gly   Pro Pro Thr 
    19415                 19420                 19425             


Asn Phe   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Thr Leu Gly 
    19430                 19435                 19440             


Trp Gly   Lys Pro Val Tyr Asp   Gly Gly Ala Pro Ile   Ile Gly Tyr 
    19445                 19450                 19455             


Val Val   Glu Met Arg Pro Lys   Ile Ala Asp Ala Ser   Pro Asp Glu 
    19460                 19465                 19470             


Gly Trp   Lys Arg Cys Asn Ala   Ala Ala Gln Leu Val   Arg Lys Glu 
    19475                 19480                 19485             


Phe Thr   Val Thr Ser Leu Asp   Glu Asn Gln Glu Tyr   Glu Phe Arg 
    19490                 19495                 19500             


Val Cys   Ala Gln Asn Gln Val   Gly Ile Gly Arg Pro   Ala Glu Leu 
    19505                 19510                 19515             


Lys Glu   Ala Ile Lys Pro Lys   Glu Ile Leu Glu Pro   Pro Glu Ile 
    19520                 19525                 19530             


Asp Leu   Asp Ala Ser Met Arg   Lys Leu Val Ile Val   Arg Ala Gly 
    19535                 19540                 19545             


Cys Pro   Ile Arg Leu Phe Ala   Ile Val Arg Gly Arg   Pro Ala Pro 
    19550                 19555                 19560             


Lys Val   Thr Trp Arg Lys Val   Gly Ile Asp Asn Val   Val Arg Lys 
    19565                 19570                 19575             


Gly Gln   Val Asp Leu Val Asp   Thr Met Ala Phe Leu   Val Ile Pro 
    19580                 19585                 19590             


Asn Ser   Thr Arg Asp Asp Ser   Gly Lys Tyr Ser Leu   Thr Leu Val 
    19595                 19600                 19605             


Asn Pro   Ala Gly Glu Lys Ala   Val Phe Val Asn Val   Arg Val Leu 
    19610                 19615                 19620             


Asp Thr   Pro Gly Pro Val Ser   Asp Leu Lys Val Ser   Asp Val Thr 
    19625                 19630                 19635             


Lys Thr   Ser Cys His Val Ser   Trp Ala Pro Pro Glu   Asn Asp Gly 
    19640                 19645                 19650             


Gly Ser   Gln Val Thr His Tyr   Ile Val Glu Lys Arg   Glu Ala Asp 
    19655                 19660                 19665             


Arg Lys   Thr Trp Ser Thr Val   Thr Pro Glu Val Lys   Lys Thr Ser 
    19670                 19675                 19680             


Phe His   Val Thr Asn Leu Val   Pro Gly Asn Glu Tyr   Tyr Phe Arg 
    19685                 19690                 19695             


Val Thr   Ala Val Asn Glu Tyr   Gly Pro Gly Val Pro   Thr Asp Val 
    19700                 19705                 19710             


Pro Lys   Pro Val Leu Ala Ser   Asp Pro Leu Ser Glu   Pro Asp Pro 
    19715                 19720                 19725             


Pro Arg   Lys Leu Glu Val Thr   Glu Met Thr Lys Asn   Ser Ala Thr 
    19730                 19735                 19740             


Leu Ala   Trp Leu Pro Pro Leu   Arg Asp Gly Gly Ala   Lys Ile Asp 
    19745                 19750                 19755             


Gly Tyr   Ile Thr Ser Tyr Arg   Glu Glu Glu Gln Pro   Ala Asp Arg 
    19760                 19765                 19770             


Trp Thr   Glu Tyr Ser Val Val   Lys Asp Leu Ser Leu   Val Val Thr 
    19775                 19780                 19785             


Gly Leu   Lys Glu Gly Lys Lys   Tyr Lys Phe Arg Val   Ala Ala Arg 
    19790                 19795                 19800             


Asn Ala   Val Gly Val Ser Leu   Pro Arg Glu Ala Glu   Gly Val Tyr 
    19805                 19810                 19815             


Glu Ala   Lys Glu Gln Leu Leu   Pro Pro Lys Ile Leu   Met Pro Glu 
    19820                 19825                 19830             


Gln Ile   Thr Ile Lys Ala Gly   Lys Lys Leu Arg Ile   Glu Ala His 
    19835                 19840                 19845             


Val Tyr   Gly Lys Pro His Pro   Thr Cys Lys Trp Lys   Lys Gly Glu 
    19850                 19855                 19860             


Asp Glu   Val Val Thr Ser Ser   His Leu Ala Val His   Lys Ala Asp 
    19865                 19870                 19875             


Ser Ser   Ser Ile Leu Ile Ile   Lys Asp Val Thr Arg   Lys Asp Ser 
    19880                 19885                 19890             


Gly Tyr   Tyr Ser Leu Thr Ala   Glu Asn Ser Ser Gly   Thr Asp Thr 
    19895                 19900                 19905             


Gln Lys   Ile Lys Val Val Val   Met Asp Ala Pro Gly   Pro Pro Gln 
    19910                 19915                 19920             


Pro Pro   Phe Asp Ile Ser Asp   Ile Asp Ala Asp Ala   Cys Ser Leu 
    19925                 19930                 19935             


Ser Trp   His Ile Pro Leu Glu   Asp Gly Gly Ser Asn   Ile Thr Asn 
    19940                 19945                 19950             


Tyr Ile   Val Glu Lys Cys Asp   Val Ser Arg Gly Asp   Trp Val Thr 
    19955                 19960                 19965             


Ala Leu   Ala Ser Val Thr Lys   Thr Ser Cys Arg Val   Gly Lys Leu 
    19970                 19975                 19980             


Ile Pro   Gly Gln Glu Tyr Ile   Phe Arg Val Arg Ala   Glu Asn Arg 
    19985                 19990                 19995             


Phe Gly   Ile Ser Glu Pro Leu   Thr Ser Pro Lys Met   Val Ala Gln 
    20000                 20005                 20010             


Phe Pro   Phe Gly Val Pro Ser   Glu Pro Lys Asn Ala   Arg Val Thr 
    20015                 20020                 20025             


Lys Val   Asn Lys Asp Cys Ile   Phe Val Ala Trp Asp   Arg Pro Asp 
    20030                 20035                 20040             


Ser Asp   Gly Gly Ser Pro Ile   Ile Gly Tyr Leu Ile   Glu Arg Lys 
    20045                 20050                 20055             


Glu Arg   Asn Ser Leu Leu Trp   Val Lys Ala Asn Asp   Thr Leu Val 
    20060                 20065                 20070             


Arg Ser   Thr Glu Tyr Pro Cys   Ala Gly Leu Val Glu   Gly Leu Glu 
    20075                 20080                 20085             


Tyr Ser   Phe Arg Ile Tyr Ala   Leu Asn Lys Ala Gly   Ser Ser Pro 
    20090                 20095                 20100             


Pro Ser   Lys Pro Thr Glu Tyr   Val Thr Ala Arg Met   Pro Val Asp 
    20105                 20110                 20115             


Pro Pro   Gly Lys Pro Glu Val   Ile Asp Val Thr Lys   Ser Thr Val 
    20120                 20125                 20130             


Ser Leu   Ile Trp Ala Arg Pro   Lys His Asp Gly Gly   Ser Lys Ile 
    20135                 20140                 20145             


Ile Gly   Tyr Phe Val Glu Ala   Cys Lys Leu Pro Gly   Asp Lys Trp 
    20150                 20155                 20160             


Val Arg   Cys Asn Thr Ala Pro   His Gln Ile Pro Gln   Glu Glu Tyr 
    20165                 20170                 20175             


Thr Ala   Thr Gly Leu Glu Glu   Lys Ala Gln Tyr Gln   Phe Arg Ala 
    20180                 20185                 20190             


Ile Ala   Arg Thr Ala Val Asn   Ile Ser Pro Pro Ser   Glu Pro Ser 
    20195                 20200                 20205             


Asp Pro   Val Thr Ile Leu Ala   Glu Asn Val Pro Pro   Arg Ile Asp 
    20210                 20215                 20220             


Leu Ser   Val Ala Met Lys Ser   Leu Leu Thr Val Lys   Ala Gly Thr 
    20225                 20230                 20235             


Asn Val   Cys Leu Asp Ala Thr   Val Phe Gly Lys Pro   Met Pro Thr 
    20240                 20245                 20250             


Val Ser   Trp Lys Lys Asp Gly   Thr Leu Leu Lys Pro   Ala Glu Gly 
    20255                 20260                 20265             


Ile Lys   Met Ala Met Gln Arg   Asn Leu Cys Thr Leu   Glu Leu Phe 
    20270                 20275                 20280             


Ser Val   Asn Arg Lys Asp Ser   Gly Asp Tyr Thr Ile   Thr Ala Glu 
    20285                 20290                 20295             


Asn Ser   Ser Gly Ser Lys Ser   Ala Thr Ile Lys Leu   Lys Val Leu 
    20300                 20305                 20310             


Asp Lys   Pro Gly Pro Pro Ala   Ser Val Lys Ile Asn   Lys Met Tyr 
    20315                 20320                 20325             


Ser Asp   Arg Ala Met Leu Ser   Trp Glu Pro Pro Leu   Glu Asp Gly 
    20330                 20335                 20340             


Gly Ser   Glu Ile Thr Asn Tyr   Ile Val Asp Lys Arg   Glu Thr Ser 
    20345                 20350                 20355             


Arg Pro   Asn Trp Ala Gln Val   Ser Ala Thr Val Pro   Ile Thr Ser 
    20360                 20365                 20370             


Cys Ser   Val Glu Lys Leu Ile   Glu Gly His Glu Tyr   Gln Phe Arg 
    20375                 20380                 20385             


Ile Cys   Ala Glu Asn Lys Tyr   Gly Val Gly Asp Pro   Val Phe Thr 
    20390                 20395                 20400             


Glu Pro   Ala Ile Ala Lys Asn   Pro Tyr Asp Pro Pro   Gly Arg Cys 
    20405                 20410                 20415             


Asp Pro   Pro Val Ile Ser Asn   Ile Thr Lys Asp His   Met Thr Val 
    20420                 20425                 20430             


Ser Trp   Lys Pro Pro Ala Asp   Asp Gly Gly Ser Pro   Ile Thr Gly 
    20435                 20440                 20445             


Tyr Leu   Leu Glu Lys Arg Glu   Thr Gln Ala Val Asn   Trp Thr Lys 
    20450                 20455                 20460             


Val Asn   Arg Lys Pro Ile Ile   Glu Arg Thr Leu Lys   Ala Thr Gly 
    20465                 20470                 20475             


Leu Gln   Glu Gly Thr Glu Tyr   Glu Phe Arg Val Thr   Ala Ile Asn 
    20480                 20485                 20490             


Lys Ala   Gly Pro Gly Lys Pro   Ser Asp Ala Ser Lys   Ala Ala Tyr 
    20495                 20500                 20505             


Ala Arg   Asp Pro Gln Tyr Pro   Pro Ala Pro Pro Ala   Phe Pro Lys 
    20510                 20515                 20520             


Val Tyr   Asp Thr Thr Arg Ser   Ser Val Ser Leu Ser   Trp Gly Lys 
    20525                 20530                 20535             


Pro Ala   Tyr Asp Gly Gly Ser   Pro Ile Ile Gly Tyr   Leu Val Glu 
    20540                 20545                 20550             


Val Lys   Arg Ala Asp Ser Asp   Asn Trp Val Arg Cys   Asn Leu Pro 
    20555                 20560                 20565             


Gln Asn   Leu Gln Lys Thr Arg   Phe Glu Val Thr Gly   Leu Met Glu 
    20570                 20575                 20580             


Asp Thr   Gln Tyr Gln Phe Arg   Val Tyr Ala Val Asn   Lys Ile Gly 
    20585                 20590                 20595             


Tyr Ser   Asp Pro Ser Asp Val   Pro Asp Lys His Tyr   Pro Lys Asp 
    20600                 20605                 20610             


Ile Leu   Ile Pro Pro Glu Gly   Glu Leu Asp Ala Asp   Leu Arg Lys 
    20615                 20620                 20625             


Thr Leu   Ile Leu Arg Ala Gly   Val Thr Met Arg Leu   Tyr Val Pro 
    20630                 20635                 20640             


Val Lys   Gly Arg Pro Pro Pro   Lys Ile Thr Trp Ser   Lys Pro Asn 
    20645                 20650                 20655             


Val Asn   Leu Arg Asp Arg Ile   Gly Leu Asp Ile Lys   Ser Thr Asp 
    20660                 20665                 20670             


Phe Asp   Thr Phe Leu Arg Cys   Glu Asn Val Asn Lys   Tyr Asp Ala 
    20675                 20680                 20685             


Gly Lys   Tyr Ile Leu Thr Leu   Glu Asn Ser Cys Gly   Lys Lys Glu 
    20690                 20695                 20700             


Tyr Thr   Ile Val Val Lys Val   Leu Asp Thr Pro Gly   Pro Pro Val 
    20705                 20710                 20715             


Asn Val   Thr Val Lys Glu Ile   Ser Lys Asp Ser Ala   Tyr Val Thr 
    20720                 20725                 20730             


Trp Glu   Pro Pro Ile Ile Asp   Gly Gly Ser Pro Ile   Ile Asn Tyr 
    20735                 20740                 20745             


Val Val   Gln Lys Arg Asp Ala   Glu Arg Lys Ser Trp   Ser Thr Val 
    20750                 20755                 20760             


Thr Thr   Glu Cys Ser Lys Thr   Ser Phe Arg Val Ala   Asn Leu Glu 
    20765                 20770                 20775             


Glu Gly   Lys Ser Tyr Phe Phe   Arg Val Phe Ala Glu   Asn Glu Tyr 
    20780                 20785                 20790             


Gly Ile   Gly Asp Pro Gly Glu   Thr Arg Asp Ala Val   Lys Ala Ser 
    20795                 20800                 20805             


Gln Thr   Pro Gly Pro Val Val   Asp Leu Lys Val Arg   Ser Val Ser 
    20810                 20815                 20820             


Lys Ser   Ser Cys Ser Ile Gly   Trp Lys Lys Pro His   Ser Asp Gly 
    20825                 20830                 20835             


Gly Ser   Arg Ile Ile Gly Tyr   Val Val Asp Phe Leu   Thr Glu Glu 
    20840                 20845                 20850             


Asn Lys   Trp Gln Arg Val Met   Lys Ser Leu Ser Leu   Gln Tyr Ser 
    20855                 20860                 20865             


Ala Lys   Asp Leu Thr Glu Gly   Lys Glu Tyr Thr Phe   Arg Val Ser 
    20870                 20875                 20880             


Ala Glu   Asn Glu Asn Gly Glu   Gly Thr Pro Ser Glu   Ile Thr Val 
    20885                 20890                 20895             


Val Ala   Arg Asp Asp Val Val   Ala Pro Asp Leu Asp   Leu Lys Gly 
    20900                 20905                 20910             


Leu Pro   Asp Leu Cys Tyr Leu   Ala Lys Glu Asn Ser   Asn Phe Arg 
    20915                 20920                 20925             


Leu Lys   Ile Pro Ile Lys Gly   Lys Pro Ala Pro Ser   Val Ser Trp 
    20930                 20935                 20940             


Lys Lys   Gly Glu Asp Pro Leu   Ala Thr Asp Thr Arg   Val Ser Val 
    20945                 20950                 20955             


Glu Ser   Ser Ala Val Asn Thr   Thr Leu Ile Val Tyr   Asp Cys Gln 
    20960                 20965                 20970             


Lys Ser   Asp Ala Gly Lys Tyr   Thr Ile Thr Leu Lys   Asn Val Ala 
    20975                 20980                 20985             


Gly Thr   Lys Glu Gly Thr Ile   Ser Ile Lys Val Val   Gly Lys Pro 
    20990                 20995                 21000             


Gly Ile   Pro Thr Gly Pro Ile   Lys Phe Asp Glu Val   Thr Ala Glu 
    21005                 21010                 21015             


Ala Met   Thr Leu Lys Trp Ala   Pro Pro Lys Asp Asp   Gly Gly Ser 
    21020                 21025                 21030             


Glu Ile   Thr Asn Tyr Ile Leu   Glu Lys Arg Asp Ser   Val Asn Asn 
    21035                 21040                 21045             


Lys Trp   Val Thr Cys Ala Ser   Ala Val Gln Lys Thr   Thr Phe Arg 
    21050                 21055                 21060             


Val Thr   Arg Leu His Glu Gly   Met Glu Tyr Thr Phe   Arg Val Ser 
    21065                 21070                 21075             


Ala Glu   Asn Lys Tyr Gly Val   Gly Glu Gly Leu Lys   Ser Glu Pro 
    21080                 21085                 21090             


Ile Val   Ala Arg His Pro Phe   Asp Val Pro Asp Ala   Pro Pro Pro 
    21095                 21100                 21105             


Pro Asn   Ile Val Asp Val Arg   His Asp Ser Val Ser   Leu Thr Trp 
    21110                 21115                 21120             


Thr Asp   Pro Lys Lys Thr Gly   Gly Ser Pro Ile Thr   Gly Tyr His 
    21125                 21130                 21135             


Leu Glu   Phe Lys Glu Arg Asn   Ser Leu Leu Trp Lys   Arg Ala Asn 
    21140                 21145                 21150             


Lys Thr   Pro Ile Arg Met Arg   Asp Phe Lys Val Thr   Gly Leu Thr 
    21155                 21160                 21165             


Glu Gly   Leu Glu Tyr Glu Phe   Arg Val Met Ala Ile   Asn Leu Ala 
    21170                 21175                 21180             


Gly Val   Gly Lys Pro Ser Leu   Pro Ser Glu Pro Val   Val Ala Leu 
    21185                 21190                 21195             


Asp Pro   Ile Asp Pro Pro Gly   Lys Pro Glu Val Ile   Asn Ile Thr 
    21200                 21205                 21210             


Arg Asn   Ser Val Thr Leu Ile   Trp Thr Glu Pro Lys   Tyr Asp Gly 
    21215                 21220                 21225             


Gly His   Lys Leu Thr Gly Tyr   Ile Val Glu Lys Arg   Asp Leu Pro 
    21230                 21235                 21240             


Ser Lys   Ser Trp Met Lys Ala   Asn His Val Asn Val   Pro Glu Cys 
    21245                 21250                 21255             


Ala Phe   Thr Val Thr Asp Leu   Val Glu Gly Gly Lys   Tyr Glu Phe 
    21260                 21265                 21270             


Arg Ile   Arg Ala Lys Asn Thr   Ala Gly Ala Ile Ser   Ala Pro Ser 
    21275                 21280                 21285             


Glu Ser   Thr Glu Thr Ile Ile   Cys Lys Asp Glu Tyr   Glu Ala Pro 
    21290                 21295                 21300             


Thr Ile   Val Leu Asp Pro Thr   Ile Lys Asp Gly Leu   Thr Ile Lys 
    21305                 21310                 21315             


Ala Gly   Asp Thr Ile Val Leu   Asn Ala Ile Ser Ile   Leu Gly Lys 
    21320                 21325                 21330             


Pro Leu   Pro Lys Ser Ser Trp   Ser Lys Ala Gly Lys   Asp Ile Arg 
    21335                 21340                 21345             


Pro Ser   Asp Ile Thr Gln Ile   Thr Ser Thr Pro Thr   Ser Ser Met 
    21350                 21355                 21360             


Leu Thr   Ile Lys Tyr Ala Thr   Arg Lys Asp Ala Gly   Glu Tyr Thr 
    21365                 21370                 21375             


Ile Thr   Ala Thr Asn Pro Phe   Gly Thr Lys Val Glu   His Val Lys 
    21380                 21385                 21390             


Val Thr   Val Leu Asp Val Pro   Gly Pro Pro Gly Pro   Val Glu Ile 
    21395                 21400                 21405             


Ser Asn   Val Ser Ala Glu Lys   Ala Thr Leu Thr Trp   Thr Pro Pro 
    21410                 21415                 21420             


Leu Glu   Asp Gly Gly Ser Pro   Ile Lys Ser Tyr Ile   Leu Glu Lys 
    21425                 21430                 21435             


Arg Glu   Thr Ser Arg Leu Leu   Trp Thr Val Val Ser   Glu Asp Ile 
    21440                 21445                 21450             


Gln Ser   Cys Arg His Val Ala   Thr Lys Leu Ile Gln   Gly Asn Glu 
    21455                 21460                 21465             


Tyr Ile   Phe Arg Val Ser Ala   Val Asn His Tyr Gly   Lys Gly Glu 
    21470                 21475                 21480             


Pro Val   Gln Ser Glu Pro Val   Lys Met Val Asp Arg   Phe Gly Pro 
    21485                 21490                 21495             


Pro Gly   Pro Pro Glu Lys Pro   Glu Val Ser Asn Val   Thr Lys Asn 
    21500                 21505                 21510             


Thr Ala   Thr Val Ser Trp Lys   Arg Pro Val Asp Asp   Gly Gly Ser 
    21515                 21520                 21525             


Glu Ile   Thr Gly Tyr His Val   Glu Arg Arg Glu Lys   Lys Ser Leu 
    21530                 21535                 21540             


Arg Trp   Val Arg Ala Ile Lys   Thr Pro Val Ser Asp   Leu Arg Cys 
    21545                 21550                 21555             


Lys Val   Thr Gly Leu Gln Glu   Gly Ser Thr Tyr Glu   Phe Arg Val 
    21560                 21565                 21570             


Ser Ala   Glu Asn Arg Ala Gly   Ile Gly Pro Pro Ser   Glu Ala Ser 
    21575                 21580                 21585             


Asp Ser   Val Leu Met Lys Asp   Ala Ala Tyr Pro Pro   Gly Pro Pro 
    21590                 21595                 21600             


Ser Asn   Pro His Val Thr Asp   Thr Thr Lys Lys Ser   Ala Ser Leu 
    21605                 21610                 21615             


Ala Trp   Gly Lys Pro His Tyr   Asp Gly Gly Leu Glu   Ile Thr Gly 
    21620                 21625                 21630             


Tyr Val   Val Glu His Gln Lys   Val Gly Asp Glu Ala   Trp Ile Lys 
    21635                 21640                 21645             


Asp Thr   Thr Gly Thr Ala Leu   Arg Ile Thr Gln Phe   Val Val Pro 
    21650                 21655                 21660             


Asp Leu   Gln Thr Lys Glu Lys   Tyr Asn Phe Arg Ile   Ser Ala Ile 
    21665                 21670                 21675             


Asn Asp   Ala Gly Val Gly Glu   Pro Ala Val Ile Pro   Asp Val Glu 
    21680                 21685                 21690             


Ile Val   Glu Arg Glu Met Ala   Pro Asp Phe Glu Leu   Asp Ala Glu 
    21695                 21700                 21705             


Leu Arg   Arg Thr Leu Val Val   Arg Ala Gly Leu Ser   Ile Arg Ile 
    21710                 21715                 21720             


Phe Val   Pro Ile Lys Gly Arg   Pro Ala Pro Glu Val   Thr Trp Thr 
    21725                 21730                 21735             


Lys Asp   Asn Ile Asn Leu Lys   Asn Arg Ala Asn Ile   Glu Asn Thr 
    21740                 21745                 21750             


Glu Ser   Phe Thr Leu Leu Ile   Ile Pro Glu Cys Asn   Arg Tyr Asp 
    21755                 21760                 21765             


Thr Gly   Lys Phe Val Met Thr   Ile Glu Asn Pro Ala   Gly Lys Lys 
    21770                 21775                 21780             


Ser Gly   Phe Val Asn Val Arg   Val Leu Asp Thr Pro   Gly Pro Val 
    21785                 21790                 21795             


Leu Asn   Leu Arg Pro Thr Asp   Ile Thr Lys Asp Ser   Val Thr Leu 
    21800                 21805                 21810             


His Trp   Asp Leu Pro Leu Ile   Asp Gly Gly Ser Arg   Ile Thr Asn 
    21815                 21820                 21825             


Tyr Ile   Val Glu Lys Arg Glu   Ala Thr Arg Lys Ser   Tyr Ser Thr 
    21830                 21835                 21840             


Ala Thr   Thr Lys Cys His Lys   Cys Thr Tyr Lys Val   Thr Gly Leu 
    21845                 21850                 21855             


Ser Glu   Gly Cys Glu Tyr Phe   Phe Arg Val Met Ala   Glu Asn Glu 
    21860                 21865                 21870             


Tyr Gly   Ile Gly Glu Pro Thr   Glu Thr Thr Glu Pro   Val Lys Ala 
    21875                 21880                 21885             


Ser Glu   Ala Pro Ser Pro Pro   Asp Ser Leu Asn Ile   Met Asp Ile 
    21890                 21895                 21900             


Thr Lys   Ser Thr Val Ser Leu   Ala Trp Pro Lys Pro   Lys His Asp 
    21905                 21910                 21915             


Gly Gly   Ser Lys Ile Thr Gly   Tyr Val Ile Glu Ala   Gln Arg Lys 
    21920                 21925                 21930             


Gly Ser   Asp Gln Trp Thr His   Ile Thr Thr Val Lys   Gly Leu Glu 
    21935                 21940                 21945             


Cys Val   Val Arg Asn Leu Thr   Glu Gly Glu Glu Tyr   Thr Phe Gln 
    21950                 21955                 21960             


Val Met   Ala Val Asn Ser Ala   Gly Arg Ser Ala Pro   Arg Glu Ser 
    21965                 21970                 21975             


Arg Pro   Val Ile Val Lys Glu   Gln Thr Met Leu Pro   Glu Leu Asp 
    21980                 21985                 21990             


Leu Arg   Gly Ile Tyr Gln Lys   Leu Val Ile Ala Lys   Ala Gly Asp 
    21995                 22000                 22005             


Asn Ile   Lys Val Glu Ile Pro   Val Leu Gly Arg Pro   Lys Pro Thr 
    22010                 22015                 22020             


Val Thr   Trp Lys Lys Gly Asp   Gln Ile Leu Lys Gln   Thr Gln Arg 
    22025                 22030                 22035             


Val Asn   Phe Glu Thr Thr Ala   Thr Ser Thr Ile Leu   Asn Ile Asn 
    22040                 22045                 22050             


Glu Cys   Val Arg Ser Asp Ser   Gly Pro Tyr Pro Leu   Thr Ala Arg 
    22055                 22060                 22065             


Asn Ile   Val Gly Glu Val Gly   Asp Val Ile Thr Ile   Gln Val His 
    22070                 22075                 22080             


Asp Ile   Pro Gly Pro Pro Thr   Gly Pro Ile Lys Phe   Asp Glu Val 
    22085                 22090                 22095             


Ser Ser   Asp Phe Val Thr Phe   Ser Trp Asp Pro Pro   Glu Asn Asp 
    22100                 22105                 22110             


Gly Gly   Val Pro Ile Ser Asn   Tyr Val Val Glu Met   Arg Gln Thr 
    22115                 22120                 22125             


Asp Ser   Thr Thr Trp Val Glu   Leu Ala Thr Thr Val   Ile Arg Thr 
    22130                 22135                 22140             


Thr Tyr   Lys Ala Thr Arg Leu   Thr Thr Gly Leu Glu   Tyr Gln Phe 
    22145                 22150                 22155             


Arg Val   Lys Ala Gln Asn Arg   Tyr Gly Val Gly Pro   Gly Ile Thr 
    22160                 22165                 22170             


Ser Ala   Cys Ile Val Ala Asn   Tyr Pro Phe Lys Val   Pro Gly Pro 
    22175                 22180                 22185             


Pro Gly   Thr Pro Gln Val Thr   Ala Val Thr Lys Asp   Ser Met Thr 
    22190                 22195                 22200             


Ile Ser   Trp His Glu Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu 
    22205                 22210                 22215             


Gly Tyr   His Val Glu Arg Lys   Glu Arg Asn Gly Ile   Leu Trp Gln 
    22220                 22225                 22230             


Thr Val   Ser Lys Ala Leu Val   Pro Gly Asn Ile Phe   Lys Ser Ser 
    22235                 22240                 22245             


Gly Leu   Thr Asp Gly Ile Ala   Tyr Glu Phe Arg Val   Ile Ala Glu 
    22250                 22255                 22260             


Asn Met   Ala Gly Lys Ser Lys   Pro Ser Lys Pro Ser   Glu Pro Met 
    22265                 22270                 22275             


Leu Ala   Leu Asp Pro Ile Asp   Pro Pro Gly Lys Pro   Val Pro Leu 
    22280                 22285                 22290             


Asn Ile   Thr Arg His Thr Val   Thr Leu Lys Trp Ala   Lys Pro Glu 
    22295                 22300                 22305             


Tyr Thr   Gly Gly Phe Lys Ile   Thr Ser Tyr Ile Val   Glu Lys Arg 
    22310                 22315                 22320             


Asp Leu   Pro Asn Gly Arg Trp   Leu Lys Ala Asn Phe   Ser Asn Ile 
    22325                 22330                 22335             


Leu Glu   Asn Glu Phe Thr Val   Ser Gly Leu Thr Glu   Asp Ala Ala 
    22340                 22345                 22350             


Tyr Glu   Phe Arg Val Ile Ala   Lys Asn Ala Ala Gly   Ala Ile Ser 
    22355                 22360                 22365             


Pro Pro   Ser Glu Pro Ser Asp   Ala Ile Thr Cys Arg   Asp Asp Val 
    22370                 22375                 22380             


Glu Ala   Pro Lys Ile Lys Val   Asp Val Lys Phe Lys   Asp Thr Val 
    22385                 22390                 22395             


Ile Leu   Lys Ala Gly Glu Ala   Phe Arg Leu Glu Ala   Asp Val Ser 
    22400                 22405                 22410             


Gly Arg   Pro Pro Pro Thr Met   Glu Trp Ser Lys Asp   Gly Lys Glu 
    22415                 22420                 22425             


Leu Glu   Gly Thr Ala Lys Leu   Glu Ile Lys Ile Ala   Asp Phe Ser 
    22430                 22435                 22440             


Thr Asn   Leu Val Asn Lys Asp   Ser Thr Arg Arg Asp   Ser Gly Ala 
    22445                 22450                 22455             


Tyr Thr   Leu Thr Ala Thr Asn   Pro Gly Gly Phe Ala   Lys His Ile 
    22460                 22465                 22470             


Phe Asn   Val Lys Val Leu Asp   Arg Pro Gly Pro Pro   Glu Gly Pro 
    22475                 22480                 22485             


Leu Ala   Val Thr Glu Val Thr   Ser Glu Lys Cys Val   Leu Ser Trp 
    22490                 22495                 22500             


Phe Pro   Pro Leu Asp Asp Gly   Gly Ala Lys Ile Asp   His Tyr Ile 
    22505                 22510                 22515             


Val Gln   Lys Arg Glu Thr Ser   Arg Leu Ala Trp Thr   Asn Val Ala 
    22520                 22525                 22530             


Ser Glu   Val Gln Val Thr Lys   Leu Lys Val Thr Lys   Leu Leu Lys 
    22535                 22540                 22545             


Gly Asn   Glu Tyr Ile Phe Arg   Val Met Ala Val Asn   Lys Tyr Gly 
    22550                 22555                 22560             


Val Gly   Glu Pro Leu Glu Ser   Glu Pro Val Leu Ala   Val Asn Pro 
    22565                 22570                 22575             


Tyr Gly   Pro Pro Asp Pro Pro   Lys Asn Pro Glu Val   Thr Thr Ile 
    22580                 22585                 22590             


Thr Lys   Asp Ser Met Val Val   Cys Trp Gly His Pro   Asp Ser Asp 
    22595                 22600                 22605             


Gly Gly   Ser Glu Ile Ile Asn   Tyr Ile Val Glu Arg   Arg Asp Lys 
    22610                 22615                 22620             


Ala Gly   Gln Arg Trp Ile Lys   Cys Asn Lys Lys Thr   Leu Thr Asp 
    22625                 22630                 22635             


Leu Arg   Tyr Lys Val Ser Gly   Leu Thr Glu Gly His   Glu Tyr Glu 
    22640                 22645                 22650             


Phe Arg   Ile Met Ala Glu Asn   Ala Ala Gly Ile Ser   Ala Pro Ser 
    22655                 22660                 22665             


Pro Thr   Ser Pro Phe Tyr Lys   Ala Cys Asp Thr Val   Phe Lys Pro 
    22670                 22675                 22680             


Gly Pro   Pro Gly Asn Pro Arg   Val Leu Asp Thr Ser   Arg Ser Ser 
    22685                 22690                 22695             


Ile Ser   Ile Ala Trp Asn Lys   Pro Ile Tyr Asp Gly   Gly Ser Glu 
    22700                 22705                 22710             


Ile Thr   Gly Tyr Met Val Glu   Ile Ala Leu Pro Glu   Glu Asp Glu 
    22715                 22720                 22725             


Trp Gln   Ile Val Thr Pro Pro   Ala Gly Leu Lys Ala   Thr Ser Tyr 
    22730                 22735                 22740             


Thr Ile   Thr Gly Leu Thr Glu   Asn Gln Glu Tyr Lys   Ile Arg Ile 
    22745                 22750                 22755             


Tyr Ala   Met Asn Ser Glu Gly   Leu Gly Glu Pro Ala   Leu Val Pro 
    22760                 22765                 22770             


Gly Thr   Pro Lys Ala Glu Asp   Arg Met Leu Pro Pro   Glu Ile Glu 
    22775                 22780                 22785             


Leu Asp   Ala Asp Leu Arg Lys   Val Val Thr Ile Arg   Ala Cys Cys 
    22790                 22795                 22800             


Thr Leu   Arg Leu Phe Val Pro   Ile Lys Gly Arg Pro   Ala Pro Glu 
    22805                 22810                 22815             


Val Lys   Trp Ala Arg Asp His   Gly Glu Ser Leu Asp   Lys Ala Ser 
    22820                 22825                 22830             


Ile Glu   Ser Thr Ser Ser Tyr   Thr Leu Leu Ile Val   Gly Asn Val 
    22835                 22840                 22845             


Asn Arg   Phe Asp Ser Gly Lys   Tyr Ile Leu Thr Val   Glu Asn Ser 
    22850                 22855                 22860             


Ser Gly   Ser Lys Ser Ala Phe   Val Asn Val Arg Val   Leu Asp Thr 
    22865                 22870                 22875             


Pro Gly   Pro Pro Gln Asp Leu   Lys Val Lys Glu Val   Thr Lys Thr 
    22880                 22885                 22890             


Ser Val   Thr Leu Thr Trp Asp   Pro Pro Leu Leu Asp   Gly Gly Ser 
    22895                 22900                 22905             


Lys Ile   Lys Asn Tyr Ile Val   Glu Lys Arg Glu Ser   Thr Arg Lys 
    22910                 22915                 22920             


Ala Tyr   Ser Thr Val Ala Thr   Asn Cys His Lys Thr   Ser Trp Lys 
    22925                 22930                 22935             


Val Asp   Gln Leu Gln Glu Gly   Cys Ser Tyr Tyr Phe   Arg Val Leu 
    22940                 22945                 22950             


Ala Glu   Asn Glu Tyr Gly Ile   Gly Leu Pro Ala Glu   Thr Ala Glu 
    22955                 22960                 22965             


Ser Val   Lys Ala Ser Glu Arg   Pro Leu Pro Pro Gly   Lys Ile Thr 
    22970                 22975                 22980             


Leu Met   Asp Val Thr Arg Asn   Ser Val Ser Leu Ser   Trp Glu Lys 
    22985                 22990                 22995             


Pro Glu   His Asp Gly Gly Ser   Arg Ile Leu Gly Tyr   Ile Val Glu 
    23000                 23005                 23010             


Met Gln   Thr Lys Gly Ser Asp   Lys Trp Ala Thr Cys   Ala Thr Val 
    23015                 23020                 23025             


Lys Val   Thr Glu Ala Thr Ile   Thr Gly Leu Ile Gln   Gly Glu Glu 
    23030                 23035                 23040             


Tyr Ser   Phe Arg Val Ser Ala   Gln Asn Glu Lys Gly   Ile Ser Asp 
    23045                 23050                 23055             


Pro Arg   Gln Leu Ser Val Pro   Val Ile Ala Lys Asp   Leu Val Ile 
    23060                 23065                 23070             


Pro Pro   Ala Phe Lys Leu Leu   Phe Asn Thr Phe Thr   Val Leu Ala 
    23075                 23080                 23085             


Gly Glu   Asp Leu Lys Val Asp   Val Pro Phe Ile Gly   Arg Pro Thr 
    23090                 23095                 23100             


Pro Ala   Val Thr Trp His Lys   Asp Asn Val Pro Leu   Lys Gln Thr 
    23105                 23110                 23115             


Thr Arg   Val Asn Ala Glu Ser   Thr Glu Asn Asn Ser   Leu Leu Thr 
    23120                 23125                 23130             


Ile Lys   Asp Ala Cys Arg Glu   Asp Val Gly His Tyr   Val Val Lys 
    23135                 23140                 23145             


Leu Thr   Asn Ser Ala Gly Glu   Ala Ile Glu Thr Leu   Asn Val Ile 
    23150                 23155                 23160             


Val Leu   Asp Lys Pro Gly Pro   Pro Thr Gly Pro Val   Lys Met Asp 
    23165                 23170                 23175             


Glu Val   Thr Ala Asp Ser Ile   Thr Leu Ser Trp Gly   Pro Pro Lys 
    23180                 23185                 23190             


Tyr Asp   Gly Gly Ser Ser Ile   Asn Asn Tyr Ile Val   Glu Lys Arg 
    23195                 23200                 23205             


Asp Thr   Ser Thr Thr Thr Trp   Gln Ile Val Ser Ala   Thr Val Ala 
    23210                 23215                 23220             


Arg Thr   Thr Ile Lys Ala Cys   Arg Leu Lys Thr Gly   Cys Glu Tyr 
    23225                 23230                 23235             


Gln Phe   Arg Ile Ala Ala Glu   Asn Arg Tyr Gly Lys   Ser Thr Tyr 
    23240                 23245                 23250             


Leu Asn   Ser Glu Pro Thr Val   Ala Gln Tyr Pro Phe   Lys Val Pro 
    23255                 23260                 23265             


Gly Pro   Pro Gly Thr Pro Val   Val Thr Leu Ser Ser   Arg Asp Ser 
    23270                 23275                 23280             


Met Glu   Val Gln Trp Asn Glu   Pro Ile Ser Asp Gly   Gly Ser Arg 
    23285                 23290                 23295             


Val Ile   Gly Tyr His Leu Glu   Arg Lys Glu Arg Asn   Ser Ile Leu 
    23300                 23305                 23310             


Trp Val   Lys Leu Asn Lys Thr   Pro Ile Pro Gln Thr   Lys Phe Lys 
    23315                 23320                 23325             


Thr Thr   Gly Leu Glu Glu Gly   Val Glu Tyr Glu Phe   Arg Val Ser 
    23330                 23335                 23340             


Ala Glu   Asn Ile Val Gly Ile   Gly Lys Pro Ser Lys   Val Ser Glu 
    23345                 23350                 23355             


Cys Tyr   Val Ala Arg Asp Pro   Cys Asp Pro Pro Gly   Arg Pro Glu 
    23360                 23365                 23370             


Ala Ile   Ile Val Thr Arg Asn   Ser Val Thr Leu Gln   Trp Lys Lys 
    23375                 23380                 23385             


Pro Thr   Tyr Asp Gly Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu 
    23390                 23395                 23400             


Lys Lys   Glu Leu Pro Glu Gly   Arg Trp Met Lys Ala   Ser Phe Thr 
    23405                 23410                 23415             


Asn Ile   Ile Asp Thr His Phe   Glu Val Thr Gly Leu   Val Glu Asp 
    23420                 23425                 23430             


His Arg   Tyr Glu Phe Arg Val   Ile Ala Arg Asn Ala   Ala Gly Val 
    23435                 23440                 23445             


Phe Ser   Glu Pro Ser Glu Ser   Thr Gly Ala Ile Thr   Ala Arg Asp 
    23450                 23455                 23460             


Glu Val   Asp Pro Pro Arg Ile   Ser Met Asp Pro Lys   Tyr Lys Asp 
    23465                 23470                 23475             


Thr Ile   Val Val His Ala Gly   Glu Ser Phe Lys Val   Asp Ala Asp 
    23480                 23485                 23490             


Ile Tyr   Gly Lys Pro Ile Pro   Thr Ile Gln Trp Ile   Lys Gly Asp 
    23495                 23500                 23505             


Gln Glu   Leu Ser Asn Thr Ala   Arg Leu Glu Ile Lys   Ser Thr Asp 
    23510                 23515                 23520             


Phe Ala   Thr Ser Leu Ser Val   Lys Asp Ala Val Arg   Val Asp Ser 
    23525                 23530                 23535             


Gly Asn   Tyr Ile Leu Lys Ala   Lys Asn Val Ala Gly   Glu Arg Ser 
    23540                 23545                 23550             


Val Thr   Val Asn Val Lys Val   Leu Asp Arg Pro Gly   Pro Pro Glu 
    23555                 23560                 23565             


Gly Pro   Val Val Ile Ser Gly   Val Thr Ala Glu Lys   Cys Thr Leu 
    23570                 23575                 23580             


Ala Trp   Lys Pro Pro Leu Gln   Asp Gly Gly Ser Asp   Ile Ile Asn 
    23585                 23590                 23595             


Tyr Ile   Val Glu Arg Arg Glu   Thr Ser Arg Leu Val   Trp Thr Val 
    23600                 23605                 23610             


Val Asp   Ala Asn Val Gln Thr   Leu Ser Cys Lys Val   Thr Lys Leu 
    23615                 23620                 23625             


Leu Glu   Gly Asn Glu Tyr Thr   Phe Arg Ile Met Ala   Val Asn Lys 
    23630                 23635                 23640             


Tyr Gly   Val Gly Glu Pro Leu   Glu Ser Glu Pro Val   Val Ala Lys 
    23645                 23650                 23655             


Asn Pro   Phe Val Val Pro Asp   Ala Pro Lys Ala Pro   Glu Val Thr 
    23660                 23665                 23670             


Thr Val   Thr Lys Asp Ser Met   Ile Val Val Trp Glu   Arg Pro Ala 
    23675                 23680                 23685             


Ser Asp   Gly Gly Ser Glu Ile   Leu Gly Tyr Val Leu   Glu Lys Arg 
    23690                 23695                 23700             


Asp Lys   Glu Gly Ile Arg Trp   Thr Arg Cys His Lys   Arg Leu Ile 
    23705                 23710                 23715             


Gly Glu   Leu Arg Leu Arg Val   Thr Gly Leu Ile Glu   Asn His Asp 
    23720                 23725                 23730             


Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Ala Ala Gly   Leu Ser Glu 
    23735                 23740                 23745             


Pro Ser   Pro Pro Ser Ala Tyr   Gln Lys Ala Cys Asp   Pro Ile Tyr 
    23750                 23755                 23760             


Lys Pro   Gly Pro Pro Asn Asn   Pro Lys Val Ile Asp   Ile Thr Arg 
    23765                 23770                 23775             


Ser Ser   Val Phe Leu Ser Trp   Ser Lys Pro Ile Tyr   Asp Gly Gly 
    23780                 23785                 23790             


Cys Glu   Ile Gln Gly Tyr Ile   Val Glu Lys Cys Asp   Val Ser Val 
    23795                 23800                 23805             


Gly Glu   Trp Thr Met Cys Thr   Pro Pro Thr Gly Ile   Asn Lys Thr 
    23810                 23815                 23820             


Asn Ile   Glu Val Glu Lys Leu   Leu Glu Lys His Glu   Tyr Asn Phe 
    23825                 23830                 23835             


Arg Ile   Cys Ala Ile Asn Lys   Ala Gly Val Gly Glu   His Ala Asp 
    23840                 23845                 23850             


Val Pro   Gly Pro Ile Ile Val   Glu Glu Lys Leu Glu   Ala Pro Asp 
    23855                 23860                 23865             


Ile Asp   Leu Asp Leu Glu Leu   Arg Lys Ile Ile Asn   Ile Arg Ala 
    23870                 23875                 23880             


Gly Gly   Ser Leu Arg Leu Phe   Val Pro Ile Lys Gly   Arg Pro Thr 
    23885                 23890                 23895             


Pro Glu   Val Lys Trp Gly Lys   Val Asp Gly Glu Ile   Arg Asp Ala 
    23900                 23905                 23910             


Ala Ile   Ile Asp Val Thr Ser   Ser Phe Thr Ser Leu   Val Leu Asp 
    23915                 23920                 23925             


Asn Val   Asn Arg Tyr Asp Ser   Gly Lys Tyr Thr Leu   Thr Leu Glu 
    23930                 23935                 23940             


Asn Ser   Ser Gly Thr Lys Ser   Ala Phe Val Thr Val   Arg Val Leu 
    23945                 23950                 23955             


Asp Thr   Pro Ser Pro Pro Val   Asn Leu Lys Val Thr   Glu Ile Thr 
    23960                 23965                 23970             


Lys Asp   Ser Val Ser Ile Thr   Trp Glu Pro Pro Leu   Leu Asp Gly 
    23975                 23980                 23985             


Gly Ser   Lys Ile Lys Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Thr 
    23990                 23995                 24000             


Arg Lys   Ser Tyr Ala Ala Val   Val Thr Asn Cys His   Lys Asn Ser 
    24005                 24010                 24015             


Trp Lys   Ile Asp Gln Leu Gln   Glu Gly Cys Ser Tyr   Tyr Phe Arg 
    24020                 24025                 24030             


Val Thr   Ala Glu Asn Glu Tyr   Gly Ile Gly Leu Pro   Ala Gln Thr 
    24035                 24040                 24045             


Ala Asp   Pro Ile Lys Val Ala   Glu Val Pro Gln Pro   Pro Gly Lys 
    24050                 24055                 24060             


Ile Thr   Val Asp Asp Val Thr   Arg Asn Ser Val Ser   Leu Ser Trp 
    24065                 24070                 24075             


Thr Lys   Pro Glu His Asp Gly   Gly Ser Lys Ile Ile   Gln Tyr Ile 
    24080                 24085                 24090             


Val Glu   Met Gln Ala Lys His   Ser Glu Lys Trp Ser   Glu Cys Ala 
    24095                 24100                 24105             


Arg Val   Lys Ser Leu Gln Ala   Val Ile Thr Asn Leu   Thr Gln Gly 
    24110                 24115                 24120             


Glu Glu   Tyr Leu Phe Arg Val   Val Ala Val Asn Glu   Lys Gly Arg 
    24125                 24130                 24135             


Ser Asp   Pro Arg Ser Leu Ala   Val Pro Ile Val Ala   Lys Asp Leu 
    24140                 24145                 24150             


Val Ile   Glu Pro Asp Val Lys   Pro Ala Phe Ser Ser   Tyr Ser Val 
    24155                 24160                 24165             


Gln Val   Gly Gln Asp Leu Lys   Ile Glu Val Pro Ile   Ser Gly Arg 
    24170                 24175                 24180             


Pro Lys   Pro Thr Ile Thr Trp   Thr Lys Asp Gly Leu   Pro Leu Lys 
    24185                 24190                 24195             


Gln Thr   Thr Arg Ile Asn Val   Thr Asp Ser Leu Asp   Leu Thr Thr 
    24200                 24205                 24210             


Leu Ser   Ile Lys Glu Thr His   Lys Asp Asp Gly Gly   Gln Tyr Gly 
    24215                 24220                 24225             


Ile Thr   Val Ala Asn Val Val   Gly Gln Lys Thr Ala   Ser Ile Glu 
    24230                 24235                 24240             


Ile Val   Thr Leu Asp Lys Pro   Asp Pro Pro Lys Gly   Pro Val Lys 
    24245                 24250                 24255             


Phe Asp   Asp Val Ser Ala Glu   Ser Ile Thr Leu Ser   Trp Asn Pro 
    24260                 24265                 24270             


Pro Leu   Tyr Thr Gly Gly Cys   Gln Ile Thr Asn Tyr   Ile Val Gln 
    24275                 24280                 24285             


Lys Arg   Asp Thr Thr Thr Thr   Val Trp Asp Val Val   Ser Ala Thr 
    24290                 24295                 24300             


Val Ala   Arg Thr Thr Leu Lys   Val Thr Lys Leu Lys   Thr Gly Thr 
    24305                 24310                 24315             


Glu Tyr   Gln Phe Arg Ile Phe   Ala Glu Asn Arg Tyr   Gly Gln Ser 
    24320                 24325                 24330             


Phe Ala   Leu Glu Ser Asp Pro   Ile Val Ala Gln Tyr   Pro Tyr Lys 
    24335                 24340                 24345             


Glu Pro   Gly Pro Pro Gly Thr   Pro Phe Ala Thr Ala   Ile Ser Lys 
    24350                 24355                 24360             


Asp Ser   Met Val Ile Gln Trp   His Glu Pro Val Asn   Asn Gly Gly 
    24365                 24370                 24375             


Ser Pro   Val Ile Gly Tyr His   Leu Glu Arg Lys Glu   Arg Asn Ser 
    24380                 24385                 24390             


Ile Leu   Trp Thr Lys Val Asn   Lys Thr Ile Ile His   Asp Thr Gln 
    24395                 24400                 24405             


Phe Lys   Ala Gln Asn Leu Glu   Glu Gly Ile Glu Tyr   Glu Phe Arg 
    24410                 24415                 24420             


Val Tyr   Ala Glu Asn Ile Val   Gly Val Gly Lys Ala   Ser Lys Asn 
    24425                 24430                 24435             


Ser Glu   Cys Tyr Val Ala Arg   Asp Pro Cys Asp Pro   Pro Gly Thr 
    24440                 24445                 24450             


Pro Glu   Pro Ile Met Val Lys   Arg Asn Glu Ile Thr   Leu Gln Trp 
    24455                 24460                 24465             


Thr Lys   Pro Val Tyr Asp Gly   Gly Ser Met Ile Thr   Gly Tyr Ile 
    24470                 24475                 24480             


Val Glu   Lys Arg Asp Leu Pro   Asp Gly Arg Trp Met   Lys Ala Ser 
    24485                 24490                 24495             


Phe Thr   Asn Val Ile Glu Thr   Gln Phe Thr Val Ser   Gly Leu Thr 
    24500                 24505                 24510             


Glu Asp   Gln Arg Tyr Glu Phe   Arg Val Ile Ala Lys   Asn Ala Ala 
    24515                 24520                 24525             


Gly Ala   Ile Ser Lys Pro Ser   Asp Ser Thr Gly Pro   Ile Thr Ala 
    24530                 24535                 24540             


Lys Asp   Glu Val Glu Leu Pro   Arg Ile Ser Met Asp   Pro Lys Phe 
    24545                 24550                 24555             


Arg Asp   Thr Ile Val Val Asn   Ala Gly Glu Thr Phe   Arg Leu Glu 
    24560                 24565                 24570             


Ala Asp   Val His Gly Lys Pro   Leu Pro Thr Ile Glu   Trp Leu Arg 
    24575                 24580                 24585             


Gly Asp   Lys Glu Ile Glu Glu   Ser Ala Arg Cys Glu   Ile Lys Asn 
    24590                 24595                 24600             


Thr Asp   Phe Lys Ala Leu Leu   Ile Val Lys Asp Ala   Ile Arg Ile 
    24605                 24610                 24615             


Asp Gly   Gly Gln Tyr Ile Leu   Arg Ala Ser Asn Val   Ala Gly Ser 
    24620                 24625                 24630             


Lys Ser   Phe Pro Val Asn Val   Lys Val Leu Asp Arg   Pro Gly Pro 
    24635                 24640                 24645             


Pro Glu   Gly Pro Val Gln Val   Thr Gly Val Thr Ser   Glu Lys Cys 
    24650                 24655                 24660             


Ser Leu   Thr Trp Ser Pro Pro   Leu Gln Asp Gly Gly   Ser Asp Ile 
    24665                 24670                 24675             


Ser His   Tyr Val Val Glu Lys   Arg Glu Thr Ser Arg   Leu Ala Trp 
    24680                 24685                 24690             


Thr Val   Val Ala Ser Glu Val   Val Thr Asn Ser Leu   Lys Val Thr 
    24695                 24700                 24705             


Lys Leu   Leu Glu Gly Asn Glu   Tyr Val Phe Arg Ile   Met Ala Val 
    24710                 24715                 24720             


Asn Lys   Tyr Gly Val Gly Glu   Pro Leu Glu Ser Ala   Pro Val Leu 
    24725                 24730                 24735             


Met Lys   Asn Pro Phe Val Leu   Pro Gly Pro Pro Lys   Ser Leu Glu 
    24740                 24745                 24750             


Val Thr   Asn Ile Ala Lys Asp   Ser Met Thr Val Cys   Trp Asn Arg 
    24755                 24760                 24765             


Pro Asp   Ser Asp Gly Gly Ser   Glu Ile Ile Gly Tyr   Ile Val Glu 
    24770                 24775                 24780             


Lys Arg   Asp Arg Ser Gly Ile   Arg Trp Ile Lys Cys   Asn Lys Arg 
    24785                 24790                 24795             


Arg Ile   Thr Asp Leu Arg Leu   Arg Val Thr Gly Leu   Thr Glu Asp 
    24800                 24805                 24810             


His Glu   Tyr Glu Phe Arg Val   Ser Ala Glu Asn Ala   Ala Gly Val 
    24815                 24820                 24825             


Gly Glu   Pro Ser Pro Ala Thr   Val Tyr Tyr Lys Ala   Cys Asp Pro 
    24830                 24835                 24840             


Val Phe   Lys Pro Gly Pro Pro   Thr Asn Ala His Ile   Val Asp Thr 
    24845                 24850                 24855             


Thr Lys   Asn Ser Ile Thr Leu   Ala Trp Gly Lys Pro   Ile Tyr Asp 
    24860                 24865                 24870             


Gly Gly   Ser Glu Ile Leu Gly   Tyr Val Val Glu Ile   Cys Lys Ala 
    24875                 24880                 24885             


Asp Glu   Glu Glu Trp Gln Ile   Val Thr Pro Gln Thr   Gly Leu Arg 
    24890                 24895                 24900             


Val Thr   Arg Phe Glu Ile Ser   Lys Leu Thr Glu His   Gln Glu Tyr 
    24905                 24910                 24915             


Lys Ile   Arg Val Cys Ala Leu   Asn Lys Val Gly Leu   Gly Glu Ala 
    24920                 24925                 24930             


Thr Ser   Val Pro Gly Thr Val   Lys Pro Glu Asp Lys   Leu Glu Ala 
    24935                 24940                 24945             


Pro Glu   Leu Asp Leu Asp Ser   Glu Leu Arg Lys Gly   Ile Val Val 
    24950                 24955                 24960             


Arg Ala   Gly Gly Ser Ala Arg   Ile His Ile Pro Phe   Lys Gly Arg 
    24965                 24970                 24975             


Pro Thr   Pro Glu Ile Thr Trp   Ser Arg Glu Glu Gly   Glu Phe Thr 
    24980                 24985                 24990             


Asp Lys   Val Gln Ile Glu Lys   Gly Val Asn Tyr Thr   Gln Leu Ser 
    24995                 25000                 25005             


Ile Asp   Asn Cys Asp Arg Asn   Asp Ala Gly Lys Tyr   Ile Leu Lys 
    25010                 25015                 25020             


Leu Glu   Asn Ser Ser Gly Ser   Lys Ser Ala Phe Val   Thr Val Lys 
    25025                 25030                 25035             


Val Leu   Asp Thr Pro Gly Pro   Pro Gln Asn Leu Ala   Val Lys Glu 
    25040                 25045                 25050             


Val Arg   Lys Asp Ser Ala Phe   Leu Val Trp Glu Pro   Pro Ile Ile 
    25055                 25060                 25065             


Asp Gly   Gly Ala Lys Val Lys   Asn Tyr Val Ile Asp   Lys Arg Glu 
    25070                 25075                 25080             


Ser Thr   Arg Lys Ala Tyr Ala   Asn Val Ser Ser Lys   Cys Ser Lys 
    25085                 25090                 25095             


Thr Ser   Phe Lys Val Glu Asn   Leu Thr Glu Gly Ala   Ile Tyr Tyr 
    25100                 25105                 25110             


Phe Arg   Val Met Ala Glu Asn   Glu Phe Gly Val Gly   Val Pro Val 
    25115                 25120                 25125             


Glu Thr   Val Asp Ala Val Lys   Ala Ala Glu Pro Pro   Ser Pro Pro 
    25130                 25135                 25140             


Gly Lys   Val Thr Leu Thr Asp   Val Ser Gln Thr Ser   Ala Ser Leu 
    25145                 25150                 25155             


Met Trp   Glu Lys Pro Glu His   Asp Gly Gly Ser Arg   Val Leu Gly 
    25160                 25165                 25170             


Tyr Val   Val Glu Met Gln Pro   Lys Gly Thr Glu Lys   Trp Ser Ile 
    25175                 25180                 25185             


Val Ala   Glu Ser Lys Val Cys   Asn Ala Val Val Thr   Gly Leu Ser 
    25190                 25195                 25200             


Ser Gly   Gln Glu Tyr Gln Phe   Arg Val Lys Ala Tyr   Asn Glu Lys 
    25205                 25210                 25215             


Gly Lys   Ser Asp Pro Arg Val   Leu Gly Val Pro Val   Ile Ala Lys 
    25220                 25225                 25230             


Asp Leu   Thr Ile Gln Pro Ser   Leu Lys Leu Pro Phe   Asn Thr Tyr 
    25235                 25240                 25245             


Ser Ile   Gln Ala Gly Glu Asp   Leu Lys Ile Glu Ile   Pro Val Ile 
    25250                 25255                 25260             


Gly Arg   Pro Arg Pro Asn Ile   Ser Trp Val Lys Asp   Gly Glu Pro 
    25265                 25270                 25275             


Leu Lys   Gln Thr Thr Arg Val   Asn Val Glu Glu Thr   Ala Thr Ser 
    25280                 25285                 25290             


Thr Val   Leu His Ile Lys Glu   Gly Asn Lys Asp Asp   Phe Gly Lys 
    25295                 25300                 25305             


Tyr Thr   Val Thr Ala Thr Asn   Ser Ala Gly Thr Ala   Thr Glu Asn 
    25310                 25315                 25320             


Leu Ser   Val Ile Val Leu Glu   Lys Pro Gly Pro Pro   Val Gly Pro 
    25325                 25330                 25335             


Val Arg   Phe Asp Glu Val Ser   Ala Asp Phe Val Val   Ile Ser Trp 
    25340                 25345                 25350             


Glu Pro   Pro Ala Tyr Thr Gly   Gly Cys Gln Ile Ser   Asn Tyr Ile 
    25355                 25360                 25365             


Val Glu   Lys Arg Asp Thr Thr   Thr Thr Thr Trp His   Met Val Ser 
    25370                 25375                 25380             


Ala Thr   Val Ala Arg Thr Thr   Ile Lys Ile Thr Lys   Leu Lys Thr 
    25385                 25390                 25395             


Gly Thr   Glu Tyr Gln Phe Arg   Ile Phe Ala Glu Asn   Arg Tyr Gly 
    25400                 25405                 25410             


Lys Ser   Ala Pro Leu Asp Ser   Lys Ala Val Ile Val   Gln Tyr Pro 
    25415                 25420                 25425             


Phe Lys   Glu Pro Gly Pro Pro   Gly Thr Pro Phe Val   Thr Ser Ile 
    25430                 25435                 25440             


Ser Lys   Asp Gln Met Leu Val   Gln Trp His Glu Pro   Val Asn Asp 
    25445                 25450                 25455             


Gly Gly   Thr Lys Ile Ile Gly   Tyr His Leu Glu Gln   Lys Glu Lys 
    25460                 25465                 25470             


Asn Ser   Ile Leu Trp Val Lys   Leu Asn Lys Thr Pro   Ile Gln Asp 
    25475                 25480                 25485             


Thr Lys   Phe Lys Thr Thr Gly   Leu Asp Glu Gly Leu   Glu Tyr Glu 
    25490                 25495                 25500             


Phe Lys   Val Ser Ala Glu Asn   Ile Val Gly Ile Gly   Lys Pro Ser 
    25505                 25510                 25515             


Lys Val   Ser Glu Cys Phe Val   Ala Arg Asp Pro Cys   Asp Pro Pro 
    25520                 25525                 25530             


Gly Arg   Pro Glu Ala Ile Val   Ile Thr Arg Asn Asn   Val Thr Leu 
    25535                 25540                 25545             


Lys Trp   Lys Lys Pro Ala Tyr   Asp Gly Gly Ser Lys   Ile Thr Gly 
    25550                 25555                 25560             


Tyr Ile   Val Glu Lys Lys Asp   Leu Pro Asp Gly Arg   Trp Met Lys 
    25565                 25570                 25575             


Ala Ser   Phe Thr Asn Val Leu   Glu Thr Glu Phe Thr   Val Ser Gly 
    25580                 25585                 25590             


Leu Val   Glu Asp Gln Arg Tyr   Glu Phe Arg Val Ile   Ala Arg Asn 
    25595                 25600                 25605             


Ala Ala   Gly Asn Phe Ser Glu   Pro Ser Asp Ser Ser   Gly Ala Ile 
    25610                 25615                 25620             


Thr Ala   Arg Asp Glu Ile Asp   Ala Pro Asn Ala Ser   Leu Asp Pro 
    25625                 25630                 25635             


Lys Tyr   Lys Asp Val Ile Val   Val His Ala Gly Glu   Thr Phe Val 
    25640                 25645                 25650             


Leu Glu   Ala Asp Ile Arg Gly   Lys Pro Ile Pro Asp   Val Val Trp 
    25655                 25660                 25665             


Ser Lys   Asp Gly Lys Glu Leu   Glu Glu Thr Ala Ala   Arg Met Glu 
    25670                 25675                 25680             


Ile Lys   Ser Thr Ile Gln Lys   Thr Thr Leu Val Val   Lys Asp Cys 
    25685                 25690                 25695             


Ile Arg   Thr Asp Gly Gly Gln   Tyr Ile Leu Lys Leu   Ser Asn Val 
    25700                 25705                 25710             


Gly Gly   Thr Lys Ser Ile Pro   Ile Thr Val Lys Val   Leu Asp Arg 
    25715                 25720                 25725             


Pro Gly   Pro Pro Glu Gly Pro   Leu Lys Val Thr Gly   Val Thr Ala 
    25730                 25735                 25740             


Glu Lys   Cys Tyr Leu Ala Trp   Asn Pro Pro Leu Gln   Asp Gly Gly 
    25745                 25750                 25755             


Ala Asn   Ile Ser His Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg 
    25760                 25765                 25770             


Leu Ser   Trp Thr Gln Val Ser   Thr Glu Val Gln Ala   Leu Asn Tyr 
    25775                 25780                 25785             


Lys Val   Thr Lys Leu Leu Pro   Gly Asn Glu Tyr Ile   Phe Arg Val 
    25790                 25795                 25800             


Met Ala   Val Asn Lys Tyr Gly   Ile Gly Glu Pro Leu   Glu Ser Gly 
    25805                 25810                 25815             


Pro Val   Thr Ala Cys Asn Pro   Tyr Lys Pro Pro Gly   Pro Pro Ser 
    25820                 25825                 25830             


Thr Pro   Glu Val Ser Ala Ile   Thr Lys Asp Ser Met   Val Val Thr 
    25835                 25840                 25845             


Trp Ala   Arg Pro Val Asp Asp   Gly Gly Thr Glu Ile   Glu Gly Tyr 
    25850                 25855                 25860             


Ile Leu   Glu Lys Arg Asp Lys   Glu Gly Val Arg Trp   Thr Lys Cys 
    25865                 25870                 25875             


Asn Lys   Lys Thr Leu Thr Asp   Leu Arg Leu Arg Val   Thr Gly Leu 
    25880                 25885                 25890             


Thr Glu   Gly His Ser Tyr Glu   Phe Arg Val Ala Ala   Glu Asn Ala 
    25895                 25900                 25905             


Ala Gly   Val Gly Glu Pro Ser   Glu Pro Ser Val Phe   Tyr Arg Ala 
    25910                 25915                 25920             


Cys Asp   Ala Leu Tyr Pro Pro   Gly Pro Pro Ser Asn   Pro Lys Val 
    25925                 25930                 25935             


Thr Asp   Thr Ser Arg Ser Ser   Val Ser Leu Ala Trp   Ser Lys Pro 
    25940                 25945                 25950             


Ile Tyr   Asp Gly Gly Ala Pro   Val Lys Gly Tyr Val   Val Glu Val 
    25955                 25960                 25965             


Lys Glu   Ala Ala Ala Asp Glu   Trp Thr Thr Cys Thr   Pro Pro Thr 
    25970                 25975                 25980             


Gly Leu   Gln Gly Lys Gln Phe   Thr Val Thr Lys Leu   Lys Glu Asn 
    25985                 25990                 25995             


Thr Glu   Tyr Asn Phe Arg Ile   Cys Ala Ile Asn Ser   Glu Gly Val 
    26000                 26005                 26010             


Gly Glu   Pro Ala Thr Leu Pro   Gly Ser Val Val Ala   Gln Glu Arg 
    26015                 26020                 26025             


Ile Glu   Pro Pro Glu Ile Glu   Leu Asp Ala Asp Leu   Arg Lys Val 
    26030                 26035                 26040             


Val Val   Leu Arg Ala Ser Ala   Thr Leu Arg Leu Phe   Val Thr Ile 
    26045                 26050                 26055             


Lys Gly   Arg Pro Glu Pro Glu   Val Lys Trp Glu Lys   Ala Glu Gly 
    26060                 26065                 26070             


Ile Leu   Thr Asp Arg Ala Gln   Ile Glu Val Thr Ser   Ser Phe Thr 
    26075                 26080                 26085             


Met Leu   Val Ile Asp Asn Val   Thr Arg Phe Asp Ser   Gly Arg Tyr 
    26090                 26095                 26100             


Asn Leu   Thr Leu Glu Asn Asn   Ser Gly Ser Lys Thr   Ala Phe Val 
    26105                 26110                 26115             


Asn Val   Arg Val Leu Asp Ser   Pro Ser Ala Pro Val   Asn Leu Thr 
    26120                 26125                 26130             


Ile Arg   Glu Val Lys Lys Asp   Ser Val Thr Leu Ser   Trp Glu Pro 
    26135                 26140                 26145             


Pro Leu   Ile Asp Gly Gly Ala   Lys Ile Thr Asn Tyr   Ile Val Glu 
    26150                 26155                 26160             


Lys Arg   Glu Thr Thr Arg Lys   Ala Tyr Ala Thr Ile   Thr Asn Asn 
    26165                 26170                 26175             


Cys Thr   Lys Thr Thr Phe Arg   Ile Glu Asn Leu Gln   Glu Gly Cys 
    26180                 26185                 26190             


Ser Tyr   Tyr Phe Arg Val Leu   Ala Ser Asn Glu Tyr   Gly Ile Gly 
    26195                 26200                 26205             


Leu Pro   Ala Glu Thr Thr Glu   Pro Val Lys Val Ser   Glu Pro Pro 
    26210                 26215                 26220             


Leu Pro   Pro Gly Arg Val Thr   Leu Val Asp Val Thr   Arg Asn Thr 
    26225                 26230                 26235             


Ala Thr   Ile Lys Trp Glu Lys   Pro Glu Ser Asp Gly   Gly Ser Lys 
    26240                 26245                 26250             


Ile Thr   Gly Tyr Val Val Glu   Met Gln Thr Lys Gly   Ser Glu Lys 
    26255                 26260                 26265             


Trp Ser   Thr Cys Thr Gln Val   Lys Thr Leu Glu Ala   Thr Ile Ser 
    26270                 26275                 26280             


Gly Leu   Thr Ala Gly Glu Glu   Tyr Val Phe Arg Val   Ala Ala Val 
    26285                 26290                 26295             


Asn Glu   Lys Gly Arg Ser Asp   Pro Arg Gln Leu Gly   Val Pro Val 
    26300                 26305                 26310             


Ile Ala   Arg Asp Ile Glu Ile   Lys Pro Ser Val Glu   Leu Pro Phe 
    26315                 26320                 26325             


His Thr   Phe Asn Val Lys Ala   Arg Glu Gln Leu Lys   Ile Asp Val 
    26330                 26335                 26340             


Pro Phe   Lys Gly Arg Pro Gln   Ala Thr Val Asn Trp   Arg Lys Asp 
    26345                 26350                 26355             


Gly Gln   Thr Leu Lys Glu Thr   Thr Arg Val Asn Val   Ser Ser Ser 
    26360                 26365                 26370             


Lys Thr   Val Thr Ser Leu Ser   Ile Lys Glu Ala Ser   Lys Glu Asp 
    26375                 26380                 26385             


Val Gly   Thr Tyr Glu Leu Cys   Val Ser Asn Ser Ala   Gly Ser Ile 
    26390                 26395                 26400             


Thr Val   Pro Ile Thr Ile Ile   Val Leu Asp Arg Pro   Gly Pro Pro 
    26405                 26410                 26415             


Gly Pro   Ile Arg Ile Asp Glu   Val Ser Cys Asp Ser   Ile Thr Ile 
    26420                 26425                 26430             


Ser Trp   Asn Pro Pro Glu Tyr   Asp Gly Gly Cys Gln   Ile Ser Asn 
    26435                 26440                 26445             


Tyr Ile   Val Glu Lys Lys Glu   Thr Thr Ser Thr Thr   Trp His Ile 
    26450                 26455                 26460             


Val Ser   Gln Ala Val Ala Arg   Thr Ser Ile Lys Ile   Val Arg Leu 
    26465                 26470                 26475             


Thr Thr   Gly Ser Glu Tyr Gln   Phe Arg Val Cys Ala   Glu Asn Arg 
    26480                 26485                 26490             


Tyr Gly   Lys Ser Ser Tyr Ser   Glu Ser Ser Ala Val   Val Ala Glu 
    26495                 26500                 26505             


Tyr Pro   Phe Ser Pro Pro Gly   Pro Pro Gly Thr Pro   Lys Val Val 
    26510                 26515                 26520             


His Ala   Thr Lys Ser Thr Met   Leu Val Thr Trp Gln   Val Pro Val 
    26525                 26530                 26535             


Asn Asp   Gly Gly Ser Arg Val   Ile Gly Tyr His Leu   Glu Tyr Lys 
    26540                 26545                 26550             


Glu Arg   Ser Ser Ile Leu Trp   Ser Lys Ala Asn Lys   Ile Leu Ile 
    26555                 26560                 26565             


Ala Asp   Thr Gln Met Lys Val   Ser Gly Leu Asp Glu   Gly Leu Met 
    26570                 26575                 26580             


Tyr Glu   Tyr Arg Val Tyr Ala   Glu Asn Ile Ala Gly   Ile Gly Lys 
    26585                 26590                 26595             


Cys Ser   Lys Ser Cys Glu Pro   Val Pro Ala Arg Asp   Pro Cys Asp 
    26600                 26605                 26610             


Pro Pro   Gly Gln Pro Glu Val   Thr Asn Ile Thr Arg   Lys Ser Val 
    26615                 26620                 26625             


Ser Leu   Lys Trp Ser Lys Pro   His Tyr Asp Gly Gly   Ala Lys Ile 
    26630                 26635                 26640             


Thr Gly   Tyr Ile Val Glu Arg   Arg Glu Leu Pro Asp   Gly Arg Trp 
    26645                 26650                 26655             


Leu Lys   Cys Asn Tyr Thr Asn   Ile Gln Glu Thr Tyr   Phe Glu Val 
    26660                 26665                 26670             


Thr Glu   Leu Thr Glu Asp Gln   Arg Tyr Glu Phe Arg   Val Phe Ala 
    26675                 26680                 26685             


Arg Asn   Ala Ala Asp Ser Val   Ser Glu Pro Ser Glu   Ser Thr Gly 
    26690                 26695                 26700             


Pro Ile   Ile Val Lys Asp Asp   Val Glu Pro Pro Arg   Val Met Met 
    26705                 26710                 26715             


Asp Val   Lys Phe Arg Asp Val   Ile Val Val Lys Ala   Gly Glu Val 
    26720                 26725                 26730             


Leu Lys   Ile Asn Ala Asp Ile   Ala Gly Arg Pro Leu   Pro Val Ile 
    26735                 26740                 26745             


Ser Trp   Ala Lys Asp Gly Ile   Glu Ile Glu Glu Arg   Ala Arg Thr 
    26750                 26755                 26760             


Glu Ile   Ile Ser Thr Asp Asn   His Thr Leu Leu Thr   Val Lys Asp 
    26765                 26770                 26775             


Cys Ile   Arg Arg Asp Thr Gly   Gln Tyr Val Leu Thr   Leu Lys Asn 
    26780                 26785                 26790             


Val Ala   Gly Thr Arg Ser Val   Ala Val Asn Cys Lys   Val Leu Asp 
    26795                 26800                 26805             


Lys Pro   Gly Pro Pro Ala Gly   Pro Leu Glu Ile Asn   Gly Leu Thr 
    26810                 26815                 26820             


Ala Glu   Lys Cys Ser Leu Ser   Trp Gly Arg Pro Gln   Glu Asp Gly 
    26825                 26830                 26835             


Gly Ala   Asp Ile Asp Tyr Tyr   Ile Val Glu Lys Arg   Glu Thr Ser 
    26840                 26845                 26850             


His Leu   Ala Trp Thr Ile Cys   Glu Gly Glu Leu Gln   Met Thr Ser 
    26855                 26860                 26865             


Cys Lys   Val Thr Lys Leu Leu   Lys Gly Asn Glu Tyr   Ile Phe Arg 
    26870                 26875                 26880             


Val Thr   Gly Val Asn Lys Tyr   Gly Val Gly Glu Pro   Leu Glu Ser 
    26885                 26890                 26895             


Val Ala   Ile Lys Ala Leu Asp   Pro Phe Thr Val Pro   Ser Pro Pro 
    26900                 26905                 26910             


Thr Ser   Leu Glu Ile Thr Ser   Val Thr Lys Glu Ser   Met Thr Leu 
    26915                 26920                 26925             


Cys Trp   Ser Arg Pro Glu Ser   Asp Gly Gly Ser Glu   Ile Ser Gly 
    26930                 26935                 26940             


Tyr Ile   Ile Glu Arg Arg Glu   Lys Asn Ser Leu Arg   Trp Val Arg 
    26945                 26950                 26955             


Val Asn   Lys Lys Pro Val Tyr   Asp Leu Arg Val Lys   Ser Thr Gly 
    26960                 26965                 26970             


Leu Arg   Glu Gly Cys Glu Tyr   Glu Tyr Arg Val Tyr   Ala Glu Asn 
    26975                 26980                 26985             


Ala Ala   Gly Leu Ser Leu Pro   Ser Glu Thr Ser Pro   Leu Ile Arg 
    26990                 26995                 27000             


Ala Glu   Asp Pro Val Phe Leu   Pro Ser Pro Pro Ser   Lys Pro Lys 
    27005                 27010                 27015             


Ile Val   Asp Ser Gly Lys Thr   Thr Ile Thr Ile Ala   Trp Val Lys 
    27020                 27025                 27030             


Pro Leu   Phe Asp Gly Gly Ala   Pro Ile Thr Gly Tyr   Thr Val Glu 
    27035                 27040                 27045             


Tyr Lys   Lys Ser Asp Asp Thr   Asp Trp Lys Thr Ser   Ile Gln Ser 
    27050                 27055                 27060             


Leu Arg   Gly Thr Glu Tyr Thr   Ile Ser Gly Leu Thr   Thr Gly Ala 
    27065                 27070                 27075             


Glu Tyr   Val Phe Arg Val Lys   Ser Val Asn Lys Val   Gly Ala Ser 
    27080                 27085                 27090             


Asp Pro   Ser Asp Ser Ser Asp   Pro Gln Ile Ala Lys   Glu Arg Glu 
    27095                 27100                 27105             


Glu Glu   Pro Leu Phe Asp Ile   Asp Ser Glu Met Arg   Lys Thr Leu 
    27110                 27115                 27120             


Ile Val   Lys Ala Gly Ala Ser   Phe Thr Met Thr Val   Pro Phe Arg 
    27125                 27130                 27135             


Gly Arg   Pro Val Pro Asn Val   Leu Trp Ser Lys Pro   Asp Thr Asp 
    27140                 27145                 27150             


Leu Arg   Thr Arg Ala Tyr Val   Asp Thr Thr Asp Ser   Arg Thr Ser 
    27155                 27160                 27165             


Leu Thr   Ile Glu Asn Ala Asn   Arg Asn Asp Ser Gly   Lys Tyr Thr 
    27170                 27175                 27180             


Leu Thr   Ile Gln Asn Val Leu   Ser Ala Ala Ser Leu   Thr Leu Val 
    27185                 27190                 27195             


Val Lys   Val Leu Asp Thr Pro   Gly Pro Pro Thr Asn   Ile Thr Val 
    27200                 27205                 27210             


Gln Asp   Val Thr Lys Glu Ser   Ala Val Leu Ser Trp   Asp Val Pro 
    27215                 27220                 27225             


Glu Asn   Asp Gly Gly Ala Pro   Val Lys Asn Tyr His   Ile Glu Lys 
    27230                 27235                 27240             


Arg Glu   Ala Ser Lys Lys Ala   Trp Val Ser Val Thr   Asn Asn Cys 
    27245                 27250                 27255             


Asn Arg   Leu Ser Tyr Lys Val   Thr Asn Leu Gln Glu   Gly Ala Ile 
    27260                 27265                 27270             


Tyr Tyr   Phe Arg Val Ser Gly   Glu Asn Glu Phe Gly   Val Gly Ile 
    27275                 27280                 27285             


Pro Ala   Glu Thr Lys Glu Gly   Val Lys Ile Thr Glu   Lys Pro Ser 
    27290                 27295                 27300             


Pro Pro   Glu Lys Leu Gly Val   Thr Ser Ile Ser Lys   Asp Ser Val 
    27305                 27310                 27315             


Ser Leu   Thr Trp Leu Lys Pro   Glu His Asp Gly Gly   Ser Arg Ile 
    27320                 27325                 27330             


Val His   Tyr Val Val Glu Ala   Leu Glu Lys Gly Gln   Lys Asn Trp 
    27335                 27340                 27345             


Val Lys   Cys Ala Val Ala Lys   Ser Thr His His Val   Val Ser Gly 
    27350                 27355                 27360             


Leu Arg   Glu Asn Ser Glu Tyr   Phe Phe Arg Val Phe   Ala Glu Asn 
    27365                 27370                 27375             


Gln Ala   Gly Leu Ser Asp Pro   Arg Glu Leu Leu Leu   Pro Val Leu 
    27380                 27385                 27390             


Ile Lys   Glu Gln Leu Glu Pro   Pro Glu Ile Asp Met   Lys Asn Phe 
    27395                 27400                 27405             


Pro Ser   His Thr Val Tyr Val   Arg Ala Gly Ser Asn   Leu Lys Val 
    27410                 27415                 27420             


Asp Ile   Pro Ile Ser Gly Lys   Pro Leu Pro Lys Val   Thr Leu Ser 
    27425                 27430                 27435             


Arg Asp   Gly Val Pro Leu Lys   Ala Thr Met Arg Phe   Asn Thr Glu 
    27440                 27445                 27450             


Ile Thr   Ala Glu Asn Leu Thr   Ile Asn Leu Lys Glu   Ser Val Thr 
    27455                 27460                 27465             


Ala Asp   Ala Gly Arg Tyr Glu   Ile Thr Ala Ala Asn   Ser Ser Gly 
    27470                 27475                 27480             


Thr Thr   Lys Ala Phe Ile Asn   Ile Val Val Leu Asp   Arg Pro Gly 
    27485                 27490                 27495             


Pro Pro   Thr Gly Pro Val Val   Ile Ser Asp Ile Thr   Glu Glu Ser 
    27500                 27505                 27510             


Val Thr   Leu Lys Trp Glu Pro   Pro Lys Tyr Asp Gly   Gly Ser Gln 
    27515                 27520                 27525             


Val Thr   Asn Tyr Ile Leu Leu   Lys Arg Glu Thr Ser   Thr Ala Val 
    27530                 27535                 27540             


Trp Thr   Glu Val Ser Ala Thr   Val Ala Arg Thr Met   Met Lys Val 
    27545                 27550                 27555             


Met Lys   Leu Thr Thr Gly Glu   Glu Tyr Gln Phe Arg   Ile Lys Ala 
    27560                 27565                 27570             


Glu Asn   Arg Phe Gly Ile Ser   Asp His Ile Asp Ser   Ala Cys Val 
    27575                 27580                 27585             


Thr Val   Lys Leu Pro Tyr Thr   Thr Pro Gly Pro Pro   Ser Thr Pro 
    27590                 27595                 27600             


Trp Val   Thr Asn Val Thr Arg   Glu Ser Ile Thr Val   Gly Trp His 
    27605                 27610                 27615             


Glu Pro   Val Ser Asn Gly Gly   Ser Ala Val Val Gly   Tyr His Leu 
    27620                 27625                 27630             


Glu Met   Lys Asp Arg Asn Ser   Ile Leu Trp Gln Lys   Ala Asn Lys 
    27635                 27640                 27645             


Leu Val   Ile Arg Thr Thr His   Phe Lys Val Thr Thr   Ile Ser Ala 
    27650                 27655                 27660             


Gly Leu   Ile Tyr Glu Phe Arg   Val Tyr Ala Glu Asn   Ala Ala Gly 
    27665                 27670                 27675             


Val Gly   Lys Pro Ser His Pro   Ser Glu Pro Val Leu   Ala Ile Asp 
    27680                 27685                 27690             


Ala Cys   Glu Pro Pro Arg Asn   Val Arg Ile Thr Asp   Ile Ser Lys 
    27695                 27700                 27705             


Asn Ser   Val Ser Leu Ser Trp   Gln Gln Pro Ala Phe   Asp Gly Gly 
    27710                 27715                 27720             


Ser Lys   Ile Thr Gly Tyr Ile   Val Glu Arg Arg Asp   Leu Pro Asp 
    27725                 27730                 27735             


Gly Arg   Trp Thr Lys Ala Ser   Phe Thr Asn Val Thr   Glu Thr Gln 
    27740                 27745                 27750             


Phe Ile   Ile Ser Gly Leu Thr   Gln Asn Ser Gln Tyr   Glu Phe Arg 
    27755                 27760                 27765             


Val Phe   Ala Arg Asn Ala Val   Gly Ser Ile Ser Asn   Pro Ser Glu 
    27770                 27775                 27780             


Val Val   Gly Pro Ile Thr Cys   Ile Asp Ser Tyr Gly   Gly Pro Val 
    27785                 27790                 27795             


Ile Asp   Leu Pro Leu Glu Tyr   Thr Glu Val Val Lys   Tyr Arg Ala 
    27800                 27805                 27810             


Gly Thr   Ser Val Lys Leu Arg   Ala Gly Ile Ser Gly   Lys Pro Ala 
    27815                 27820                 27825             


Pro Thr   Ile Glu Trp Tyr Lys   Asp Asp Lys Glu Leu   Gln Thr Asn 
    27830                 27835                 27840             


Ala Leu   Val Cys Val Glu Asn   Thr Thr Asp Leu Ala   Ser Ile Leu 
    27845                 27850                 27855             


Ile Lys   Asp Ala Asp Arg Leu   Asn Ser Gly Cys Tyr   Glu Leu Lys 
    27860                 27865                 27870             


Leu Arg   Asn Ala Met Gly Ser   Ala Ser Ala Thr Ile   Arg Val Gln 
    27875                 27880                 27885             


Ile Leu   Asp Lys Pro Gly Pro   Pro Gly Gly Pro Ile   Glu Phe Lys 
    27890                 27895                 27900             


Thr Val   Thr Ala Glu Lys Ile   Thr Leu Leu Trp Arg   Pro Pro Ala 
    27905                 27910                 27915             


Asp Asp   Gly Gly Ala Lys Ile   Thr His Tyr Ile Val   Glu Lys Arg 
    27920                 27925                 27930             


Glu Thr   Ser Arg Val Val Trp   Ser Met Val Ser Glu   His Leu Glu 
    27935                 27940                 27945             


Glu Cys   Ile Ile Thr Thr Thr   Lys Ile Ile Lys Gly   Asn Glu Tyr 
    27950                 27955                 27960             


Ile Phe   Arg Val Arg Ala Val   Asn Lys Tyr Gly Ile   Gly Glu Pro 
    27965                 27970                 27975             


Leu Glu   Ser Asp Ser Val Val   Ala Lys Asn Ala Phe   Val Thr Pro 
    27980                 27985                 27990             


Gly Pro   Pro Gly Ile Pro Glu   Val Thr Lys Ile Thr   Lys Asn Ser 
    27995                 28000                 28005             


Met Thr   Val Val Trp Ser Arg   Pro Ile Ala Asp Gly   Gly Ser Asp 
    28010                 28015                 28020             


Ile Ser   Gly Tyr Phe Leu Glu   Lys Arg Asp Lys Lys   Ser Leu Gly 
    28025                 28030                 28035             


Trp Phe   Lys Val Leu Lys Glu   Thr Ile Arg Asp Thr   Arg Gln Lys 
    28040                 28045                 28050             


Val Thr   Gly Leu Thr Glu Asn   Ser Asp Tyr Gln Tyr   Arg Val Cys 
    28055                 28060                 28065             


Ala Val   Asn Ala Ala Gly Gln   Gly Pro Phe Ser Glu   Pro Ser Glu 
    28070                 28075                 28080             


Phe Tyr   Lys Ala Ala Asp Pro   Ile Asp Pro Pro Gly   Pro Pro Ala 
    28085                 28090                 28095             


Lys Ile   Arg Ile Ala Asp Ser   Thr Lys Ser Ser Ile   Thr Leu Gly 
    28100                 28105                 28110             


Trp Ser   Lys Pro Val Tyr Asp   Gly Gly Ser Ala Val   Thr Gly Tyr 
    28115                 28120                 28125             


Val Val   Glu Ile Arg Gln Gly   Glu Glu Glu Glu Trp   Thr Thr Val 
    28130                 28135                 28140             


Ser Thr   Lys Gly Glu Val Arg   Thr Thr Glu Tyr Val   Val Ser Asn 
    28145                 28150                 28155             


Leu Lys   Pro Gly Val Asn Tyr   Tyr Phe Arg Val Ser   Ala Val Asn 
    28160                 28165                 28170             


Cys Ala   Gly Gln Gly Glu Pro   Ile Glu Met Asn Glu   Pro Val Gln 
    28175                 28180                 28185             


Ala Lys   Asp Ile Leu Glu Ala   Pro Glu Ile Asp Leu   Asp Val Ala 
    28190                 28195                 28200             


Leu Arg   Thr Ser Val Ile Ala   Lys Ala Gly Glu Asp   Val Gln Val 
    28205                 28210                 28215             


Leu Ile   Pro Phe Lys Gly Arg   Pro Pro Pro Thr Val   Thr Trp Arg 
    28220                 28225                 28230             


Lys Asp   Glu Lys Asn Leu Gly   Ser Asp Ala Arg Tyr   Ser Ile Glu 
    28235                 28240                 28245             


Asn Thr   Asp Ser Ser Ser Leu   Leu Thr Ile Pro Gln   Val Thr Arg 
    28250                 28255                 28260             


Asn Asp   Thr Gly Lys Tyr Ile   Leu Thr Ile Glu Asn   Gly Val Gly 
    28265                 28270                 28275             


Glu Pro   Lys Ser Ser Thr Val   Ser Val Lys Val Leu   Asp Thr Pro 
    28280                 28285                 28290             


Ala Ala   Cys Gln Lys Leu Gln   Val Lys His Val Ser   Arg Gly Thr 
    28295                 28300                 28305             


Val Thr   Leu Leu Trp Asp Pro   Pro Leu Ile Asp Gly   Gly Ser Pro 
    28310                 28315                 28320             


Ile Ile   Asn Tyr Val Ile Glu   Lys Arg Asp Ala Thr   Lys Arg Thr 
    28325                 28330                 28335             


Trp Ser   Val Val Ser His Lys   Cys Ser Ser Thr Ser   Phe Lys Leu 
    28340                 28345                 28350             


Ile Asp   Leu Ser Glu Lys Thr   Pro Phe Phe Phe Arg   Val Leu Ala 
    28355                 28360                 28365             


Glu Asn   Glu Ile Gly Ile Gly   Glu Pro Cys Glu Thr   Thr Glu Pro 
    28370                 28375                 28380             


Val Lys   Ala Ala Glu Val Pro   Ala Pro Ile Arg Asp   Leu Ser Met 
    28385                 28390                 28395             


Lys Asp   Ser Thr Lys Thr Ser   Val Ile Leu Ser Trp   Thr Lys Pro 
    28400                 28405                 28410             


Asp Phe   Asp Gly Gly Ser Val   Ile Thr Glu Tyr Val   Val Glu Arg 
    28415                 28420                 28425             


Lys Gly   Lys Gly Glu Gln Thr   Trp Ser His Ala Gly   Ile Ser Lys 
    28430                 28435                 28440             


Thr Cys   Glu Ile Glu Val Ser   Gln Leu Lys Glu Gln   Ser Val Leu 
    28445                 28450                 28455             


Glu Phe   Arg Val Phe Ala Lys   Asn Glu Lys Gly Leu   Ser Asp Pro 
    28460                 28465                 28470             


Val Thr   Ile Gly Pro Ile Thr   Val Lys Glu Leu Ile   Ile Thr Pro 
    28475                 28480                 28485             


Glu Val   Asp Leu Ser Asp Ile   Pro Gly Ala Gln Val   Thr Val Arg 
    28490                 28495                 28500             


Ile Gly   His Asn Val His Leu   Glu Leu Pro Tyr Lys   Gly Lys Pro 
    28505                 28510                 28515             


Lys Pro   Ser Ile Ser Trp Leu   Lys Asp Gly Leu Pro   Leu Lys Glu 
    28520                 28525                 28530             


Ser Glu   Phe Val Arg Phe Ser   Lys Thr Glu Asn Lys   Ile Thr Leu 
    28535                 28540                 28545             


Ser Ile   Lys Asn Ala Lys Lys   Glu His Gly Gly Lys   Tyr Thr Val 
    28550                 28555                 28560             


Ile Leu   Asp Asn Ala Val Cys   Arg Ile Ala Val Pro   Ile Thr Val 
    28565                 28570                 28575             


Ile Thr   Leu Gly Pro Pro Ser   Lys Pro Lys Gly Pro   Ile Arg Phe 
    28580                 28585                 28590             


Asp Glu   Ile Lys Ala Asp Ser   Val Ile Leu Ser Trp   Asp Val Pro 
    28595                 28600                 28605             


Glu Asp   Asn Gly Gly Gly Glu   Ile Thr Cys Tyr Ser   Ile Glu Lys 
    28610                 28615                 28620             


Arg Glu   Thr Ser Gln Thr Asn   Trp Lys Met Val Cys   Ser Ser Val 
    28625                 28630                 28635             


Ala Arg   Thr Thr Phe Lys Val   Pro Asn Leu Val Lys   Asp Ala Glu 
    28640                 28645                 28650             


Tyr Gln   Phe Arg Val Arg Ala   Glu Asn Arg Tyr Gly   Val Ser Gln 
    28655                 28660                 28665             


Pro Leu   Val Ser Ser Ile Ile   Val Ala Lys His Gln   Phe Arg Ile 
    28670                 28675                 28680             


Pro Gly   Pro Pro Gly Lys Pro   Val Ile Tyr Asn Val   Thr Ser Asp 
    28685                 28690                 28695             


Gly Met   Ser Leu Thr Trp Asp   Ala Pro Val Tyr Asp   Gly Gly Ser 
    28700                 28705                 28710             


Glu Val   Thr Gly Phe His Val   Glu Lys Lys Glu Arg   Asn Ser Ile 
    28715                 28720                 28725             


Leu Trp   Gln Lys Val Asn Thr   Ser Pro Ile Ser Gly   Arg Glu Tyr 
    28730                 28735                 28740             


Arg Ala   Thr Gly Leu Val Glu   Gly Leu Asp Tyr Gln   Phe Arg Val 
    28745                 28750                 28755             


Tyr Ala   Glu Asn Ser Ala Gly   Leu Ser Ser Pro Ser   Asp Pro Ser 
    28760                 28765                 28770             


Lys Phe   Thr Leu Ala Val Ser   Pro Val Asp Pro Pro   Gly Thr Pro 
    28775                 28780                 28785             


Asp Tyr   Ile Asp Val Thr Arg   Glu Thr Ile Thr Leu   Lys Trp Asn 
    28790                 28795                 28800             


Pro Pro   Leu Arg Asp Gly Gly   Ser Lys Ile Val Gly   Tyr Ser Ile 
    28805                 28810                 28815             


Glu Lys   Arg Gln Gly Asn Glu   Arg Trp Val Arg Cys   Asn Phe Thr 
    28820                 28825                 28830             


Asp Val   Ser Glu Cys Gln Tyr   Thr Val Thr Gly Leu   Ser Pro Gly 
    28835                 28840                 28845             


Asp Arg   Tyr Glu Phe Arg Ile   Ile Ala Arg Asn Ala   Val Gly Thr 
    28850                 28855                 28860             


Ile Ser   Pro Pro Ser Gln Ser   Ser Gly Ile Ile Met   Thr Arg Asp 
    28865                 28870                 28875             


Glu Asn   Val Pro Pro Ile Val   Glu Phe Gly Pro Glu   Tyr Phe Asp 
    28880                 28885                 28890             


Gly Leu   Ile Ile Lys Ser Gly   Glu Ser Leu Arg Ile   Lys Ala Leu 
    28895                 28900                 28905             


Val Gln   Gly Arg Pro Val Pro   Arg Val Thr Trp Phe   Lys Asp Gly 
    28910                 28915                 28920             


Val Glu   Ile Glu Lys Arg Met   Asn Met Glu Ile Thr   Asp Val Leu 
    28925                 28930                 28935             


Gly Ser   Thr Ser Leu Phe Val   Arg Asp Ala Thr Arg   Asp His Arg 
    28940                 28945                 28950             


Gly Val   Tyr Thr Val Glu Ala   Lys Asn Ala Ser Gly   Ser Ala Lys 
    28955                 28960                 28965             


Ala Glu   Ile Lys Val Lys Val   Gln Asp Thr Pro Gly   Lys Val Val 
    28970                 28975                 28980             


Gly Pro   Ile Arg Phe Thr Asn   Ile Thr Gly Glu Lys   Met Thr Leu 
    28985                 28990                 28995             


Trp Trp   Asp Ala Pro Leu Asn   Asp Gly Cys Ala Pro   Ile Thr His 
    29000                 29005                 29010             


Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg Leu Ala   Trp Ala Leu 
    29015                 29020                 29025             


Ile Glu   Asp Lys Cys Glu Ala   Gln Ser Tyr Thr Ala   Ile Lys Leu 
    29030                 29035                 29040             


Ile Asn   Gly Asn Glu Tyr Gln   Phe Arg Val Ser Ala   Val Asn Lys 
    29045                 29050                 29055             


Phe Gly   Val Gly Arg Pro Leu   Asp Ser Asp Pro Val   Val Ala Gln 
    29060                 29065                 29070             


Ile Gln   Tyr Thr Val Pro Asp   Ala Pro Gly Ile Pro   Glu Pro Ser 
    29075                 29080                 29085             


Asn Ile   Thr Gly Asn Ser Ile   Thr Leu Thr Trp Ala   Arg Pro Glu 
    29090                 29095                 29100             


Ser Asp   Gly Gly Ser Glu Ile   Gln Gln Tyr Ile Leu   Glu Arg Arg 
    29105                 29110                 29115             


Glu Lys   Lys Ser Thr Arg Trp   Val Lys Val Ile Ser   Lys Arg Pro 
    29120                 29125                 29130             


Ile Ser   Glu Thr Arg Phe Lys   Val Thr Gly Leu Thr   Glu Gly Asn 
    29135                 29140                 29145             


Glu Tyr   Glu Phe His Val Met   Ala Glu Asn Ala Ala   Gly Val Gly 
    29150                 29155                 29160             


Pro Ala   Ser Gly Ile Ser Arg   Leu Ile Lys Cys Arg   Glu Pro Val 
    29165                 29170                 29175             


Asn Pro   Pro Gly Pro Pro Thr   Val Val Lys Val Thr   Asp Thr Ser 
    29180                 29185                 29190             


Lys Thr   Thr Val Ser Leu Glu   Trp Ser Lys Pro Val   Phe Asp Gly 
    29195                 29200                 29205             


Gly Met   Glu Ile Ile Gly Tyr   Ile Ile Glu Met Cys   Lys Ala Asp 
    29210                 29215                 29220             


Leu Gly   Asp Trp His Lys Val   Asn Ala Glu Ala Cys   Val Lys Thr 
    29225                 29230                 29235             


Arg Tyr   Thr Val Thr Asp Leu   Gln Ala Gly Glu Glu   Tyr Lys Phe 
    29240                 29245                 29250             


Arg Val   Ser Ala Ile Asn Gly   Ala Gly Lys Gly Asp   Ser Cys Glu 
    29255                 29260                 29265             


Val Thr   Gly Thr Ile Lys Ala   Val Asp Arg Leu Thr   Ala Pro Glu 
    29270                 29275                 29280             


Leu Asp   Ile Asp Ala Asn Phe   Lys Gln Thr His Val   Val Arg Ala 
    29285                 29290                 29295             


Gly Ala   Ser Ile Arg Leu Phe   Ile Ala Tyr Gln Gly   Arg Pro Thr 
    29300                 29305                 29310             


Pro Thr   Ala Val Trp Ser Lys   Pro Asp Ser Asn Leu   Ser Leu Arg 
    29315                 29320                 29325             


Ala Asp   Ile His Thr Thr Asp   Ser Phe Ser Thr Leu   Thr Val Glu 
    29330                 29335                 29340             


Asn Cys   Asn Arg Asn Asp Ala   Gly Lys Tyr Thr Leu   Thr Val Glu 
    29345                 29350                 29355             


Asn Asn   Ser Gly Ser Lys Ser   Ile Thr Phe Thr Val   Lys Val Leu 
    29360                 29365                 29370             


Asp Thr   Pro Gly Pro Pro Gly   Pro Ile Thr Phe Lys   Asp Val Thr 
    29375                 29380                 29385             


Arg Gly   Ser Ala Thr Leu Met   Trp Asp Ala Pro Leu   Leu Asp Gly 
    29390                 29395                 29400             


Gly Ala   Arg Ile His His Tyr   Val Val Glu Lys Arg   Glu Ala Ser 
    29405                 29410                 29415             


Arg Arg   Ser Trp Gln Val Ile   Ser Glu Lys Cys Thr   Arg Gln Ile 
    29420                 29425                 29430             


Phe Lys   Val Asn Asp Leu Ala   Glu Gly Val Pro Tyr   Tyr Phe Arg 
    29435                 29440                 29445             


Val Ser   Ala Val Asn Glu Tyr   Gly Val Gly Glu Pro   Tyr Glu Met 
    29450                 29455                 29460             


Pro Glu   Pro Ile Val Ala Thr   Glu Gln Pro Ala Pro   Pro Arg Arg 
    29465                 29470                 29475             


Leu Asp   Val Val Asp Thr Ser   Lys Ser Ser Ala Val   Leu Ala Trp 
    29480                 29485                 29490             


Leu Lys   Pro Asp His Asp Gly   Gly Ser Arg Ile Thr   Gly Tyr Leu 
    29495                 29500                 29505             


Leu Glu   Met Arg Gln Lys Gly   Ser Asp Phe Trp Val   Glu Ala Gly 
    29510                 29515                 29520             


His Thr   Lys Gln Leu Thr Phe   Thr Val Glu Arg Leu   Val Glu Lys 
    29525                 29530                 29535             


Thr Glu   Tyr Glu Phe Arg Val   Lys Ala Lys Asn Asp   Ala Gly Tyr 
    29540                 29545                 29550             


Ser Glu   Pro Arg Glu Ala Phe   Ser Ser Val Ile Ile   Lys Glu Pro 
    29555                 29560                 29565             


Gln Ile   Glu Pro Thr Ala Asp   Leu Thr Gly Ile Thr   Asn Gln Leu 
    29570                 29575                 29580             


Ile Thr   Cys Lys Ala Gly Ser   Pro Phe Thr Ile Asp   Val Pro Ile 
    29585                 29590                 29595             


Ser Gly   Arg Pro Ala Pro Lys   Val Thr Trp Lys Leu   Glu Glu Met 
    29600                 29605                 29610             


Arg Leu   Lys Glu Thr Asp Arg   Val Ser Ile Thr Thr   Thr Lys Asp 
    29615                 29620                 29625             


Arg Thr   Thr Leu Thr Val Lys   Asp Ser Met Arg Gly   Asp Ser Gly 
    29630                 29635                 29640             


Arg Tyr   Phe Leu Thr Leu Glu   Asn Thr Ala Gly Val   Lys Thr Phe 
    29645                 29650                 29655             


Ser Val   Thr Val Val Val Ile   Gly Arg Pro Gly Pro   Val Thr Gly 
    29660                 29665                 29670             


Pro Ile   Glu Val Ser Ser Val   Ser Ala Glu Ser Cys   Val Leu Ser 
    29675                 29680                 29685             


Trp Gly   Glu Pro Lys Asp Gly   Gly Gly Thr Glu Ile   Thr Asn Tyr 
    29690                 29695                 29700             


Ile Val   Glu Lys Arg Glu Ser   Gly Thr Thr Ala Trp   Gln Leu Val 
    29705                 29710                 29715             


Asn Ser   Ser Val Lys Arg Thr   Gln Ile Lys Val Thr   His Leu Thr 
    29720                 29725                 29730             


Lys Tyr   Met Glu Tyr Ser Phe   Arg Val Ser Ser Glu   Asn Arg Phe 
    29735                 29740                 29745             


Gly Val   Ser Lys Pro Leu Glu   Ser Ala Pro Ile Ile   Ala Glu His 
    29750                 29755                 29760             


Pro Phe   Val Pro Pro Ser Ala   Pro Thr Arg Pro Glu   Val Tyr His 
    29765                 29770                 29775             


Val Ser   Ala Asn Ala Met Ser   Ile Arg Trp Glu Glu   Pro Tyr His 
    29780                 29785                 29790             


Asp Gly   Gly Ser Lys Ile Ile   Gly Tyr Trp Val Glu   Lys Lys Glu 
    29795                 29800                 29805             


Arg Asn   Thr Ile Leu Trp Val   Lys Glu Asn Lys Val   Pro Cys Leu 
    29810                 29815                 29820             


Glu Cys   Asn Tyr Lys Val Thr   Gly Leu Val Glu Gly   Leu Glu Tyr 
    29825                 29830                 29835             


Gln Phe   Arg Thr Tyr Ala Leu   Asn Ala Ala Gly Val   Ser Lys Ala 
    29840                 29845                 29850             


Ser Glu   Ala Ser Arg Pro Ile   Met Ala Gln Asn Pro   Val Asp Ala 
    29855                 29860                 29865             


Pro Gly   Arg Pro Glu Val Thr   Asp Val Thr Arg Ser   Thr Val Ser 
    29870                 29875                 29880             


Leu Ile   Trp Ser Ala Pro Ala   Tyr Asp Gly Gly Ser   Lys Val Val 
    29885                 29890                 29895             


Gly Tyr   Ile Ile Glu Arg Lys   Pro Val Ser Glu Val   Gly Asp Gly 
    29900                 29905                 29910             


Arg Trp   Leu Lys Cys Asn Tyr   Thr Ile Val Ser Asp   Asn Phe Phe 
    29915                 29920                 29925             


Thr Val   Thr Ala Leu Ser Glu   Gly Asp Thr Tyr Glu   Phe Arg Val 
    29930                 29935                 29940             


Leu Ala   Lys Asn Ala Ala Gly   Val Ile Ser Lys Gly   Ser Glu Ser 
    29945                 29950                 29955             


Thr Gly   Pro Val Thr Cys Arg   Asp Glu Tyr Ala Pro   Pro Lys Ala 
    29960                 29965                 29970             


Glu Leu   Asp Ala Arg Leu His   Gly Asp Leu Val Thr   Ile Arg Ala 
    29975                 29980                 29985             


Gly Ser   Asp Leu Val Leu Asp   Ala Ala Val Gly Gly   Lys Pro Glu 
    29990                 29995                 30000             


Pro Lys   Ile Ile Trp Thr Lys   Gly Asp Lys Glu Leu   Asp Leu Cys 
    30005                 30010                 30015             


Glu Lys   Val Ser Leu Gln Tyr   Thr Gly Lys Arg Ala   Thr Ala Val 
    30020                 30025                 30030             


Ile Lys   Phe Cys Asp Arg Ser   Asp Ser Gly Lys Tyr   Thr Leu Thr 
    30035                 30040                 30045             


Val Lys   Asn Ala Ser Gly Thr   Lys Ala Val Ser Val   Met Val Lys 
    30050                 30055                 30060             


Val Leu   Asp Ser Pro Gly Pro   Cys Gly Lys Leu Thr   Val Ser Arg 
    30065                 30070                 30075             


Val Thr   Gln Glu Lys Cys Thr   Leu Ala Trp Ser Leu   Pro Gln Glu 
    30080                 30085                 30090             


Asp Gly   Gly Ala Glu Ile Thr   His Tyr Ile Val Glu   Arg Arg Glu 
    30095                 30100                 30105             


Thr Ser   Arg Leu Asn Trp Val   Ile Val Glu Gly Glu   Cys Pro Thr 
    30110                 30115                 30120             


Leu Ser   Tyr Val Val Thr Arg   Leu Ile Lys Asn Asn   Glu Tyr Ile 
    30125                 30130                 30135             


Phe Arg   Val Arg Ala Val Asn   Lys Tyr Gly Pro Gly   Val Pro Val 
    30140                 30145                 30150             


Glu Ser   Glu Pro Ile Val Ala   Arg Asn Ser Phe Thr   Ile Pro Ser 
    30155                 30160                 30165             


Pro Pro   Gly Ile Pro Glu Glu   Val Gly Thr Gly Lys   Glu His Ile 
    30170                 30175                 30180             


Ile Ile   Gln Trp Thr Lys Pro   Glu Ser Asp Gly Gly   Asn Glu Ile 
    30185                 30190                 30195             


Ser Asn   Tyr Leu Val Asp Lys   Arg Glu Lys Lys Ser   Leu Arg Trp 
    30200                 30205                 30210             


Thr Arg   Val Asn Lys Asp Tyr   Val Val Tyr Asp Thr   Arg Leu Lys 
    30215                 30220                 30225             


Val Thr   Ser Leu Met Glu Gly   Cys Asp Tyr Gln Phe   Arg Val Thr 
    30230                 30235                 30240             


Ala Val   Asn Ala Ala Gly Asn   Ser Glu Pro Ser Glu   Ala Ser Asn 
    30245                 30250                 30255             


Phe Ile   Ser Cys Arg Glu Pro   Ser Tyr Thr Pro Gly   Pro Pro Ser 
    30260                 30265                 30270             


Ala Pro   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Ser Leu Ala 
    30275                 30280                 30285             


Trp Thr   Lys Pro Met Tyr Asp   Gly Gly Thr Asp Ile   Val Gly Tyr 
    30290                 30295                 30300             


Val Leu   Glu Met Gln Glu Lys   Asp Thr Asp Gln Trp   Tyr Arg Val 
    30305                 30310                 30315             


His Thr   Asn Ala Thr Ile Arg   Asn Thr Glu Phe Thr   Val Pro Asp 
    30320                 30325                 30330             


Leu Lys   Met Gly Gln Lys Tyr   Ser Phe Arg Val Ala   Ala Val Asn 
    30335                 30340                 30345             


Val Lys   Gly Met Ser Glu Tyr   Ser Glu Ser Ile Ala   Glu Ile Glu 
    30350                 30355                 30360             


Pro Val   Glu Arg Ile Glu Ile   Pro Asp Leu Glu Leu   Ala Asp Asp 
    30365                 30370                 30375             


Leu Lys   Lys Thr Val Thr Ile   Arg Ala Gly Ala Ser   Leu Arg Leu 
    30380                 30385                 30390             


Met Val   Ser Val Ser Gly Arg   Pro Pro Pro Val Ile   Thr Trp Ser 
    30395                 30400                 30405             


Lys Gln   Gly Ile Asp Leu Ala   Ser Arg Ala Ile Ile   Asp Thr Thr 
    30410                 30415                 30420             


Glu Ser   Tyr Ser Leu Leu Ile   Val Asp Lys Val Asn   Arg Tyr Asp 
    30425                 30430                 30435             


Ala Gly   Lys Tyr Thr Ile Glu   Ala Glu Asn Gln Ser   Gly Lys Lys 
    30440                 30445                 30450             


Ser Ala   Thr Val Leu Val Lys   Val Tyr Asp Thr Pro   Gly Pro Cys 
    30455                 30460                 30465             


Pro Ser   Val Lys Val Lys Glu   Val Ser Arg Asp Ser   Val Thr Ile 
    30470                 30475                 30480             


Thr Trp   Glu Ile Pro Thr Ile   Asp Gly Gly Ala Pro   Val Asn Asn 
    30485                 30490                 30495             


Tyr Ile   Val Glu Lys Arg Glu   Ala Ala Met Arg Ala   Phe Lys Thr 
    30500                 30505                 30510             


Val Thr   Thr Lys Cys Ser Lys   Thr Leu Tyr Arg Ile   Ser Gly Leu 
    30515                 30520                 30525             


Val Glu   Gly Thr Met Tyr Tyr   Phe Arg Val Leu Pro   Glu Asn Ile 
    30530                 30535                 30540             


Tyr Gly   Ile Gly Glu Pro Cys   Glu Thr Ser Asp Ala   Val Leu Val 
    30545                 30550                 30555             


Ser Glu   Val Pro Leu Val Pro   Ala Lys Leu Glu Val   Val Asp Val 
    30560                 30565                 30570             


Thr Lys   Ser Thr Val Thr Leu   Ala Trp Glu Lys Pro   Leu Tyr Asp 
    30575                 30580                 30585             


Gly Gly   Ser Arg Leu Thr Gly   Tyr Val Leu Glu Ala   Cys Lys Ala 
    30590                 30595                 30600             


Gly Thr   Glu Arg Trp Met Lys   Val Val Thr Leu Lys   Pro Thr Val 
    30605                 30610                 30615             


Leu Glu   His Thr Val Thr Ser   Leu Asn Glu Gly Glu   Gln Tyr Leu 
    30620                 30625                 30630             


Phe Arg   Ile Arg Ala Gln Asn   Glu Lys Gly Val Ser   Glu Pro Arg 
    30635                 30640                 30645             


Glu Thr   Val Thr Ala Val Thr   Val Gln Asp Leu Arg   Val Leu Pro 
    30650                 30655                 30660             


Thr Ile   Asp Leu Ser Thr Met   Pro Gln Lys Thr Ile   His Val Pro 
    30665                 30670                 30675             


Ala Gly   Arg Pro Val Glu Leu   Val Ile Pro Ile Ala   Gly Arg Pro 
    30680                 30685                 30690             


Pro Pro   Ala Ala Ser Trp Phe   Phe Ala Gly Ser Lys   Leu Arg Glu 
    30695                 30700                 30705             


Ser Glu   Arg Val Thr Val Glu   Thr His Thr Lys Val   Ala Lys Leu 
    30710                 30715                 30720             


Thr Ile   Arg Glu Thr Thr Ile   Arg Asp Thr Gly Glu   Tyr Thr Leu 
    30725                 30730                 30735             


Glu Leu   Lys Asn Val Thr Gly   Thr Thr Ser Glu Thr   Ile Lys Val 
    30740                 30745                 30750             


Ile Ile   Leu Asp Lys Pro Gly   Pro Pro Thr Gly Pro   Ile Lys Ile 
    30755                 30760                 30765             


Asp Glu   Ile Asp Ala Thr Ser   Ile Thr Ile Ser Trp   Glu Pro Pro 
    30770                 30775                 30780             


Glu Leu   Asp Gly Gly Ala Pro   Leu Ser Gly Tyr Val   Val Glu Gln 
    30785                 30790                 30795             


Arg Asp   Ala His Arg Pro Gly   Trp Leu Pro Val Ser   Glu Ser Val 
    30800                 30805                 30810             


Thr Arg   Ser Thr Phe Lys Phe   Thr Arg Leu Thr Glu   Gly Asn Glu 
    30815                 30820                 30825             


Tyr Val   Phe Arg Val Ala Ala   Thr Asn Arg Phe Gly   Ile Gly Ser 
    30830                 30835                 30840             


Tyr Leu   Gln Ser Glu Val Ile   Glu Cys Arg Ser Ser   Ile Arg Ile 
    30845                 30850                 30855             


Pro Gly   Pro Pro Glu Thr Leu   Gln Ile Phe Asp Val   Ser Arg Asp 
    30860                 30865                 30870             


Gly Met   Thr Leu Thr Trp Tyr   Pro Pro Glu Asp Asp   Gly Gly Ser 
    30875                 30880                 30885             


Gln Val   Thr Gly Tyr Ile Val   Glu Arg Lys Glu Val   Arg Ala Asp 
    30890                 30895                 30900             


Arg Trp   Val Arg Val Asn Lys   Val Pro Val Thr Met   Thr Arg Tyr 
    30905                 30910                 30915             


Arg Ser   Thr Gly Leu Thr Glu   Gly Leu Glu Tyr Glu   His Arg Val 
    30920                 30925                 30930             


Thr Ala   Ile Asn Ala Arg Gly   Ser Gly Lys Pro Ser   Arg Pro Ser 
    30935                 30940                 30945             


Lys Pro   Ile Val Ala Met Asp   Pro Ile Ala Pro Pro   Gly Lys Pro 
    30950                 30955                 30960             


Gln Asn   Pro Arg Val Thr Asp   Thr Thr Arg Thr Ser   Val Ser Leu 
    30965                 30970                 30975             


Ala Trp   Ser Val Pro Glu Asp   Glu Gly Gly Ser Lys   Val Thr Gly 
    30980                 30985                 30990             


Tyr Leu   Ile Glu Met Gln Lys   Val Asp Gln His Glu   Trp Thr Lys 
    30995                 31000                 31005             


Cys Asn   Thr Thr Pro Thr Lys   Ile Arg Glu Tyr Thr   Leu Thr His 
    31010                 31015                 31020             


Leu Pro   Gln Gly Ala Glu Tyr   Arg Phe Arg Val Leu   Ala Cys Asn 
    31025                 31030                 31035             


Ala Gly   Gly Pro Gly Glu Pro   Ala Glu Val Pro Gly   Thr Val Lys 
    31040                 31045                 31050             


Val Thr   Glu Met Leu Glu Tyr   Pro Asp Tyr Glu Leu   Asp Glu Arg 
    31055                 31060                 31065             


Tyr Gln   Glu Gly Ile Phe Val   Arg Gln Gly Gly Val   Ile Arg Leu 
    31070                 31075                 31080             


Thr Ile   Pro Ile Lys Gly Lys   Pro Phe Pro Ile Cys   Lys Trp Thr 
    31085                 31090                 31095             


Lys Glu   Gly Gln Asp Ile Ser   Lys Arg Ala Met Ile   Ala Thr Ser 
    31100                 31105                 31110             


Glu Thr   His Thr Glu Leu Val   Ile Lys Glu Ala Asp   Arg Gly Asp 
    31115                 31120                 31125             


Ser Gly   Thr Tyr Asp Leu Val   Leu Glu Asn Lys Cys   Gly Lys Lys 
    31130                 31135                 31140             


Ala Val   Tyr Ile Lys Val Arg   Val Ile Gly Ser Pro   Asn Ser Pro 
    31145                 31150                 31155             


Glu Gly   Pro Leu Glu Tyr Asp   Asp Ile Gln Val Arg   Ser Val Arg 
    31160                 31165                 31170             


Val Ser   Trp Arg Pro Pro Ala   Asp Asp Gly Gly Ala   Asp Ile Leu 
    31175                 31180                 31185             


Gly Tyr   Ile Leu Glu Arg Arg   Glu Val Pro Lys Ala   Ala Trp Tyr 
    31190                 31195                 31200             


Thr Ile   Asp Ser Arg Val Arg   Gly Thr Ser Leu Val   Val Lys Gly 
    31205                 31210                 31215             


Leu Lys   Glu Asn Val Glu Tyr   His Phe Arg Val Ser   Ala Glu Asn 
    31220                 31225                 31230             


Gln Phe   Gly Ile Ser Lys Pro   Leu Lys Ser Glu Glu   Pro Val Thr 
    31235                 31240                 31245             


Pro Lys   Thr Pro Leu Asn Pro   Pro Glu Pro Pro Ser   Asn Pro Pro 
    31250                 31255                 31260             


Glu Val   Leu Asp Val Thr Lys   Ser Ser Val Ser Leu   Ser Trp Ser 
    31265                 31270                 31275             


Arg Pro   Lys Asp Asp Gly Gly   Ser Arg Val Thr Gly   Tyr Tyr Ile 
    31280                 31285                 31290             


Glu Arg   Lys Glu Thr Ser Thr   Asp Lys Trp Val Arg   His Asn Lys 
    31295                 31300                 31305             


Thr Gln   Ile Thr Thr Thr Met   Tyr Thr Val Thr Gly   Leu Val Pro 
    31310                 31315                 31320             


Asp Ala   Glu Tyr Gln Phe Arg   Ile Ile Ala Gln Asn   Asp Val Gly 
    31325                 31330                 31335             


Leu Ser   Glu Thr Ser Pro Ala   Ser Glu Pro Val Val   Cys Lys Asp 
    31340                 31345                 31350             


Pro Phe   Asp Lys Pro Ser Gln   Pro Gly Glu Leu Glu   Ile Leu Ser 
    31355                 31360                 31365             


Ile Ser   Lys Asp Ser Val Thr   Leu Gln Trp Glu Lys   Pro Glu Cys 
    31370                 31375                 31380             


Asp Gly   Gly Lys Glu Ile Leu   Gly Tyr Trp Val Glu   Tyr Arg Gln 
    31385                 31390                 31395             


Ser Gly   Asp Ser Ala Trp Lys   Lys Ser Asn Lys Glu   Arg Ile Lys 
    31400                 31405                 31410             


Asp Lys   Gln Phe Thr Ile Gly   Gly Leu Leu Glu Ala   Thr Glu Tyr 
    31415                 31420                 31425             


Glu Phe   Arg Val Phe Ala Glu   Asn Glu Thr Gly Leu   Ser Arg Pro 
    31430                 31435                 31440             


Arg Arg   Thr Ala Met Ser Ile   Lys Thr Lys Leu Thr   Ser Gly Glu 
    31445                 31450                 31455             


Ala Pro   Gly Ile Arg Lys Glu   Met Lys Asp Val Thr   Thr Lys Leu 
    31460                 31465                 31470             


Gly Glu   Ala Ala Gln Leu Ser   Cys Gln Ile Val Gly   Arg Pro Leu 
    31475                 31480                 31485             


Pro Asp   Ile Lys Trp Tyr Arg   Phe Gly Lys Glu Leu   Ile Gln Ser 
    31490                 31495                 31500             


Arg Lys   Tyr Lys Met Ser Ser   Asp Gly Arg Thr His   Thr Leu Thr 
    31505                 31510                 31515             


Val Met   Thr Glu Glu Gln Glu   Asp Glu Gly Val Tyr   Thr Cys Ile 
    31520                 31525                 31530             


Ala Thr   Asn Glu Val Gly Glu   Val Glu Thr Ser Ser   Lys Leu Leu 
    31535                 31540                 31545             


Leu Gln   Ala Thr Pro Gln Phe   His Pro Gly Tyr Pro   Leu Lys Glu 
    31550                 31555                 31560             


Lys Tyr   Tyr Gly Ala Val Gly   Ser Thr Leu Arg Leu   His Val Met 
    31565                 31570                 31575             


Tyr Ile   Gly Arg Pro Val Pro   Ala Met Thr Trp Phe   His Gly Gln 
    31580                 31585                 31590             


Lys Leu   Leu Gln Asn Ser Glu   Asn Ile Thr Ile Glu   Asn Thr Glu 
    31595                 31600                 31605             


His Tyr   Thr His Leu Val Met   Lys Asn Val Gln Arg   Lys Thr His 
    31610                 31615                 31620             


Ala Gly   Lys Tyr Lys Val Gln   Leu Ser Asn Val Phe   Gly Thr Val 
    31625                 31630                 31635             


Asp Ala   Ile Leu Asp Val Glu   Ile Gln Asp Lys Pro   Asp Lys Pro 
    31640                 31645                 31650             


Thr Gly   Pro Ile Val Ile Glu   Ala Leu Leu Lys Asn   Ser Ala Val 
    31655                 31660                 31665             


Ile Ser   Trp Lys Pro Pro Ala   Asp Asp Gly Gly Ser   Trp Ile Thr 
    31670                 31675                 31680             


Asn Tyr   Val Val Glu Lys Cys   Glu Ala Lys Glu Gly   Ala Glu Trp 
    31685                 31690                 31695             


Gln Leu   Val Ser Ser Ala Ile   Ser Val Thr Thr Cys   Arg Ile Val 
    31700                 31705                 31710             


Asn Leu   Thr Glu Asn Ala Gly   Tyr Tyr Phe Arg Val   Ser Ala Gln 
    31715                 31720                 31725             


Asn Thr   Phe Gly Ile Ser Asp   Pro Leu Glu Val Ser   Ser Val Val 
    31730                 31735                 31740             


Ile Ile   Lys Ser Pro Phe Glu   Lys Pro Gly Ala Pro   Gly Lys Pro 
    31745                 31750                 31755             


Thr Ile   Thr Ala Val Thr Lys   Asp Ser Cys Val Val   Ala Trp Lys 
    31760                 31765                 31770             


Pro Pro   Ala Ser Asp Gly Gly   Ala Lys Ile Arg Asn   Tyr Tyr Leu 
    31775                 31780                 31785             


Glu Lys   Arg Glu Lys Lys Gln   Asn Lys Trp Ile Ser   Val Thr Thr 
    31790                 31795                 31800             


Glu Glu   Ile Arg Glu Thr Val   Phe Ser Val Lys Asn   Leu Ile Glu 
    31805                 31810                 31815             


Gly Leu   Glu Tyr Glu Phe Arg   Val Lys Cys Glu Asn   Leu Gly Gly 
    31820                 31825                 31830             


Glu Ser   Glu Trp Ser Glu Ile   Ser Glu Pro Ile Thr   Pro Lys Ser 
    31835                 31840                 31845             


Asp Val   Pro Ile Gln Ala Pro   His Phe Lys Glu Glu   Leu Arg Asn 
    31850                 31855                 31860             


Leu Asn   Val Arg Tyr Gln Ser   Asn Ala Thr Leu Val   Cys Lys Val 
    31865                 31870                 31875             


Thr Gly   His Pro Lys Pro Ile   Val Lys Trp Tyr Arg   Gln Gly Lys 
    31880                 31885                 31890             


Glu Ile   Ile Ala Asp Gly Leu   Lys Tyr Arg Ile Gln   Glu Phe Lys 
    31895                 31900                 31905             


Gly Gly   Tyr His Gln Leu Ile   Ile Ala Ser Val Thr   Asp Asp Asp 
    31910                 31915                 31920             


Ala Thr   Val Tyr Gln Val Arg   Ala Thr Asn Gln Gly   Gly Ser Val 
    31925                 31930                 31935             


Ser Gly   Thr Ala Ser Leu Glu   Val Glu Val Pro Ala   Lys Ile His 
    31940                 31945                 31950             


Leu Pro   Lys Thr Leu Glu Gly   Met Gly Ala Val His   Ala Leu Arg 
    31955                 31960                 31965             


Gly Glu   Val Val Ser Ile Lys   Ile Pro Phe Ser Gly   Lys Pro Asp 
    31970                 31975                 31980             


Pro Val   Ile Thr Trp Gln Lys   Gly Gln Asp Leu Ile   Asp Asn Asn 
    31985                 31990                 31995             


Gly His   Tyr Gln Val Ile Val   Thr Arg Ser Phe Thr   Ser Leu Val 
    32000                 32005                 32010             


Phe Pro   Asn Gly Val Glu Arg   Lys Asp Ala Gly Phe   Tyr Val Val 
    32015                 32020                 32025             


Cys Ala   Lys Asn Arg Phe Gly   Ile Asp Gln Lys Thr   Val Glu Leu 
    32030                 32035                 32040             


Asp Val   Ala Asp Val Pro Asp   Pro Pro Arg Gly Val   Lys Val Ser 
    32045                 32050                 32055             


Asp Val   Ser Arg Asp Ser Val   Asn Leu Thr Trp Thr   Glu Pro Ala 
    32060                 32065                 32070             


Ser Asp   Gly Gly Ser Lys Ile   Thr Asn Tyr Ile Val   Glu Lys Cys 
    32075                 32080                 32085             


Ala Thr   Thr Ala Glu Arg Trp   Leu Arg Val Gly Gln   Ala Arg Glu 
    32090                 32095                 32100             


Thr Arg   Tyr Thr Val Ile Asn   Leu Phe Gly Lys Thr   Ser Tyr Gln 
    32105                 32110                 32115             


Phe Arg   Val Ile Ala Glu Asn   Lys Phe Gly Leu Ser   Lys Pro Ser 
    32120                 32125                 32130             


Glu Pro   Ser Glu Pro Thr Ile   Thr Lys Glu Asp Lys   Thr Arg Ala 
    32135                 32140                 32145             


Met Asn   Tyr Asp Glu Glu Val   Asp Glu Thr Arg Glu   Val Ser Met 
    32150                 32155                 32160             


Thr Lys   Ala Ser His Ser Ser   Thr Lys Glu Leu Tyr   Glu Lys Tyr 
    32165                 32170                 32175             


Met Ile   Ala Glu Asp Leu Gly   Arg Gly Glu Phe Gly   Ile Val His 
    32180                 32185                 32190             


Arg Cys   Val Glu Thr Ser Ser   Lys Lys Thr Tyr Met   Ala Lys Phe 
    32195                 32200                 32205             


Val Lys   Val Lys Gly Thr Asp   Gln Val Leu Val Lys   Lys Glu Ile 
    32210                 32215                 32220             


Ser Ile   Leu Asn Ile Ala Arg   His Arg Asn Ile Leu   His Leu His 
    32225                 32230                 32235             


Glu Ser   Phe Glu Ser Met Glu   Glu Leu Val Met Ile   Phe Glu Phe 
    32240                 32245                 32250             


Ile Ser   Gly Leu Asp Ile Phe   Glu Arg Ile Asn Thr   Ser Ala Phe 
    32255                 32260                 32265             


Glu Leu   Asn Glu Arg Glu Ile   Val Ser Tyr Val His   Gln Val Cys 
    32270                 32275                 32280             


Glu Ala   Leu Gln Phe Leu His   Ser His Asn Ile Gly   His Phe Asp 
    32285                 32290                 32295             


Ile Arg   Pro Glu Asn Ile Ile   Tyr Gln Thr Arg Arg   Ser Ser Thr 
    32300                 32305                 32310             


Ile Lys   Ile Ile Glu Phe Gly   Gln Ala Arg Gln Leu   Lys Pro Gly 
    32315                 32320                 32325             


Asp Asn   Phe Arg Leu Leu Phe   Thr Ala Pro Glu Tyr   Tyr Ala Pro 
    32330                 32335                 32340             


Glu Val   His Gln His Asp Val   Val Ser Thr Ala Thr   Asp Met Trp 
    32345                 32350                 32355             


Ser Leu   Gly Thr Leu Val Tyr   Val Leu Leu Ser Gly   Ile Asn Pro 
    32360                 32365                 32370             


Phe Leu   Ala Glu Thr Asn Gln   Gln Ile Ile Glu Asn   Ile Met Asn 
    32375                 32380                 32385             


Ala Glu   Tyr Thr Phe Asp Glu   Glu Ala Phe Lys Glu   Ile Ser Ile 
    32390                 32395                 32400             


Glu Ala   Met Asp Phe Val Asp   Arg Leu Leu Val Lys   Glu Arg Lys 
    32405                 32410                 32415             


Ser Arg   Met Thr Ala Ser Glu   Ala Leu Gln His Pro   Trp Leu Lys 
    32420                 32425                 32430             


Gln Lys   Ile Glu Arg Val Ser   Thr Lys Val Ile Arg   Thr Leu Lys 
    32435                 32440                 32445             


His Arg   Arg Tyr Tyr His Thr   Leu Ile Lys Lys Asp   Leu Asn Met 
    32450                 32455                 32460             


Val Val   Ser Ala Ala Arg Ile   Ser Cys Gly Gly Ala   Ile Arg Ser 
    32465                 32470                 32475             


Gln Lys   Gly Val Ser Val Ala   Lys Val Lys Val Ala   Ser Ile Glu 
    32480                 32485                 32490             


Ile Gly   Pro Val Ser Gly Gln   Ile Met His Ala Val   Gly Glu Glu 
    32495                 32500                 32505             


Gly Gly   His Val Lys Tyr Val   Cys Lys Ile Glu Asn   Tyr Asp Gln 
    32510                 32515                 32520             


Ser Thr   Gln Val Thr Trp Tyr   Phe Gly Val Arg Gln   Leu Glu Asn 
    32525                 32530                 32535             


Ser Glu   Lys Tyr Glu Ile Thr   Tyr Glu Asp Gly Val   Ala Ile Leu 
    32540                 32545                 32550             


Tyr Val   Lys Asp Ile Thr Lys   Leu Asp Asp Gly Thr   Tyr Arg Cys 
    32555                 32560                 32565             


Lys Val   Val Asn Asp Tyr Gly   Glu Asp Ser Ser Tyr   Ala Glu Leu 
    32570                 32575                 32580             


Phe Val   Lys Gly Val Arg Glu   Val Tyr Asp Tyr Tyr   Cys Arg Arg 
    32585                 32590                 32595             


Thr Met   Lys Lys Ile Lys Arg   Arg Thr Asp Thr Met   Arg Leu Leu 
    32600                 32605                 32610             


Glu Arg   Pro Pro Glu Phe Thr   Leu Pro Leu Tyr Asn   Lys Thr Ala 
    32615                 32620                 32625             


Tyr Val   Gly Glu Asn Val Arg   Phe Gly Val Thr Ile   Thr Val His 
    32630                 32635                 32640             


Pro Glu   Pro His Val Thr Trp   Tyr Lys Ser Gly Gln   Lys Ile Lys 
    32645                 32650                 32655             


Pro Gly   Asp Asn Asp Lys Lys   Tyr Thr Phe Glu Ser   Asp Lys Gly 
    32660                 32665                 32670             


Leu Tyr   Gln Leu Thr Ile Asn   Ser Val Thr Thr Asp   Asp Asp Ala 
    32675                 32680                 32685             


Glu Tyr   Thr Val Val Ala Arg   Asn Lys Tyr Gly Glu   Asp Ser Cys 
    32690                 32695                 32700             


Lys Ala   Lys Leu Thr Val Thr   Leu His Pro Pro Pro   Thr Asp Ser 
    32705                 32710                 32715             


Thr Leu   Arg Pro Met Phe Lys   Arg Leu Leu Ala Asn   Ala Glu Cys 
    32720                 32725                 32730             


Gln Glu   Gly Gln Ser Val Cys   Phe Glu Ile Arg Val   Ser Gly Ile 
    32735                 32740                 32745             


Pro Pro   Pro Thr Leu Lys Trp   Glu Lys Asp Gly Gln   Pro Leu Ser 
    32750                 32755                 32760             


Leu Gly   Pro Asn Ile Glu Ile   Ile His Glu Gly Leu   Asp Tyr Tyr 
    32765                 32770                 32775             


Ala Leu   His Ile Arg Asp Thr   Leu Pro Glu Asp Thr   Gly Tyr Tyr 
    32780                 32785                 32790             


Arg Val   Thr Ala Thr Asn Thr   Ala Gly Ser Thr Ser   Cys Gln Ala 
    32795                 32800                 32805             


His Leu   Gln Val Glu Arg Leu   Arg Tyr Lys Lys Gln   Glu Phe Lys 
    32810                 32815                 32820             


Ser Lys   Glu Glu His Glu Arg   His Val Gln Lys Gln   Ile Asp Lys 
    32825                 32830                 32835             


Thr Leu   Arg Met Ala Glu Ile   Leu Ser Gly Thr Glu   Ser Val Pro 
    32840                 32845                 32850             


Leu Thr   Gln Val Ala Lys Glu   Ala Leu Arg Glu Ala   Ala Val Leu 
    32855                 32860                 32865             


Tyr Lys   Pro Ala Val Ser Thr   Lys Thr Val Lys Gly   Glu Phe Arg 
    32870                 32875                 32880             


Leu Glu   Ile Glu Glu Lys Lys   Glu Glu Arg Lys Leu   Arg Met Pro 
    32885                 32890                 32895             


Tyr Asp   Val Pro Glu Pro Arg   Lys Tyr Lys Gln Thr   Thr Ile Glu 
    32900                 32905                 32910             


Glu Asp   Gln Arg Ile Lys Gln   Phe Val Pro Met Ser   Asp Met Lys 
    32915                 32920                 32925             


Trp Tyr   Lys Lys Ile Arg Asp   Gln Tyr Glu Met Pro   Gly Lys Leu 
    32930                 32935                 32940             


Asp Arg   Val Val Gln Lys Arg   Pro Lys Arg Ile Arg   Leu Ser Arg 
    32945                 32950                 32955             


Trp Glu   Gln Phe Tyr Val Met   Pro Leu Pro Arg Ile   Thr Asp Gln 
    32960                 32965                 32970             


Tyr Arg   Pro Lys Trp Arg Ile   Pro Lys Leu Ser Gln   Asp Asp Leu 
    32975                 32980                 32985             


Glu Ile   Val Arg Pro Ala Arg   Arg Arg Thr Pro Ser   Pro Asp Tyr 
    32990                 32995                 33000             


Asp Phe   Tyr Tyr Arg Pro Arg   Arg Arg Ser Leu Gly   Asp Ile Ser 
    33005                 33010                 33015             


Asp Glu   Glu Leu Leu Leu Pro   Ile Asp Asp Tyr Leu   Ala Met Lys 
    33020                 33025                 33030             


Arg Thr   Glu Glu Glu Arg Leu   Arg Leu Glu Glu Glu   Leu Glu Leu 
    33035                 33040                 33045             


Gly Phe   Ser Ala Ser Pro Pro   Ser Arg Ser Pro Pro   His Phe Glu 
    33050                 33055                 33060             


Leu Ser   Ser Leu Arg Tyr Ser   Ser Pro Gln Ala His   Val Lys Val 
    33065                 33070                 33075             


Glu Glu   Thr Arg Lys Asp Phe   Arg Tyr Ser Thr Tyr   His Ile Pro 
    33080                 33085                 33090             


Thr Lys   Ala Glu Ala Ser Thr   Ser Tyr Ala Glu Leu   Arg Glu Arg 
    33095                 33100                 33105             


His Ala   Gln Ala Ala Tyr Arg   Gln Pro Lys Gln Arg   Gln Arg Ile 
    33110                 33115                 33120             


Met Ala   Glu Arg Glu Asp Glu   Glu Leu Leu Arg Pro   Val Thr Thr 
    33125                 33130                 33135             


Thr Gln   His Leu Ser Glu Tyr   Lys Ser Glu Leu Asp   Phe Met Ser 
    33140                 33145                 33150             


Lys Glu   Glu Lys Ser Arg Lys   Lys Ser Arg Arg Gln   Arg Glu Val 
    33155                 33160                 33165             


Thr Glu   Ile Thr Glu Ile Glu   Glu Glu Tyr Glu Ile   Ser Lys His 
    33170                 33175                 33180             


Ala Gln   Arg Glu Ser Ser Ser   Ser Ala Ser Arg Leu   Leu Arg Arg 
    33185                 33190                 33195             


Arg Arg   Ser Leu Ser Pro Thr   Tyr Ile Glu Leu Met   Arg Pro Val 
    33200                 33205                 33210             


Ser Glu   Leu Ile Arg Ser Arg   Pro Gln Pro Ala Glu   Glu Tyr Glu 
    33215                 33220                 33225             


Asp Asp   Thr Glu Arg Arg Ser   Pro Thr Pro Glu Arg   Thr Arg Pro 
    33230                 33235                 33240             


Arg Ser   Pro Ser Pro Val Ser   Ser Glu Arg Ser Leu   Ser Arg Phe 
    33245                 33250                 33255             


Glu Arg   Ser Ala Arg Phe Asp   Ile Phe Ser Arg Tyr   Glu Ser Met 
    33260                 33265                 33270             


Lys Ala   Ala Leu Lys Thr Gln   Lys Thr Ser Glu Arg   Lys Tyr Glu 
    33275                 33280                 33285             


Val Leu   Ser Gln Gln Pro Phe   Thr Leu Asp His Ala   Pro Arg Ile 
    33290                 33295                 33300             


Thr Leu   Arg Met Arg Ser His   Arg Val Pro Cys Gly   Gln Asn Thr 
    33305                 33310                 33315             


Arg Phe   Ile Leu Asn Val Gln   Ser Lys Pro Thr Ala   Glu Val Lys 
    33320                 33325                 33330             


Trp Tyr   His Asn Gly Val Glu   Leu Gln Glu Ser Ser   Lys Ile His 
    33335                 33340                 33345             


Tyr Thr   Asn Thr Ser Gly Val   Leu Thr Leu Glu Ile   Leu Asp Cys 
    33350                 33355                 33360             


His Thr   Asp Asp Ser Gly Thr   Tyr Arg Ala Val Cys   Thr Asn Tyr 
    33365                 33370                 33375             


Lys Gly   Glu Ala Ser Asp Tyr   Ala Thr Leu Asp Val   Thr Gly Gly 
    33380                 33385                 33390             


Asp Tyr   Thr Thr Tyr Ala Ser   Gln Arg Arg Asp Glu   Glu Val Pro 
    33395                 33400                 33405             


Arg Ser   Val Phe Pro Glu Leu   Thr Arg Thr Glu Ala   Tyr Ala Val 
    33410                 33415                 33420             


Ser Ser   Phe Lys Lys Thr Ser   Glu Met Glu Ala Ser   Ser Ser Val 
    33425                 33430                 33435             


Arg Glu   Val Lys Ser Gln Met   Thr Glu Thr Arg Glu   Ser Leu Ser 
    33440                 33445                 33450             


Ser Tyr   Glu His Ser Ala Ser   Ala Glu Met Lys Ser   Ala Ala Leu 
    33455                 33460                 33465             


Glu Glu   Lys Ser Leu Glu Glu   Lys Ser Thr Thr Arg   Lys Ile Lys 
    33470                 33475                 33480             


Thr Thr   Leu Ala Ala Arg Ile   Leu Thr Lys Pro Arg   Ser Met Thr 
    33485                 33490                 33495             


Val Tyr   Glu Gly Glu Ser Ala   Arg Phe Ser Cys Asp   Thr Asp Gly 
    33500                 33505                 33510             


Glu Pro   Val Pro Thr Val Thr   Trp Leu Arg Lys Gly   Gln Val Leu 
    33515                 33520                 33525             


Ser Thr   Ser Ala Arg His Gln   Val Thr Thr Thr Lys   Tyr Lys Ser 
    33530                 33535                 33540             


Thr Phe   Glu Ile Ser Ser Val   Gln Ala Ser Asp Glu   Gly Asn Tyr 
    33545                 33550                 33555             


Ser Val   Val Val Glu Asn Ser   Glu Gly Lys Gln Glu   Ala Glu Phe 
    33560                 33565                 33570             


Thr Leu   Thr Ile Gln Lys Ala   Arg Val Thr Glu Lys   Ala Val Thr 
    33575                 33580                 33585             


Ser Pro   Pro Arg Val Lys Ser   Pro Glu Pro Arg Val   Lys Ser Pro 
    33590                 33595                 33600             


Glu Ala   Val Lys Ser Pro Lys   Arg Val Lys Ser Pro   Glu Pro Ser 
    33605                 33610                 33615             


His Pro   Lys Ala Val Ser Pro   Thr Glu Thr Lys Pro   Thr Pro Thr 
    33620                 33625                 33630             


Glu Lys   Val Gln His Leu Pro   Val Ser Ala Pro Pro   Lys Ile Thr 
    33635                 33640                 33645             


Gln Phe   Leu Lys Ala Glu Ala   Ser Lys Glu Ile Ala   Lys Leu Thr 
    33650                 33655                 33660             


Cys Val   Val Glu Ser Ser Val   Leu Arg Ala Lys Glu   Val Thr Trp 
    33665                 33670                 33675             


Tyr Lys   Asp Gly Lys Lys Leu   Lys Glu Asn Gly His   Phe Gln Phe 
    33680                 33685                 33690             


His Tyr   Ser Ala Asp Gly Thr   Tyr Glu Leu Lys Ile   Asn Asn Leu 
    33695                 33700                 33705             


Thr Glu   Ser Asp Gln Gly Glu   Tyr Val Cys Glu Ile   Ser Gly Glu 
    33710                 33715                 33720             


Gly Gly   Thr Ser Lys Thr Asn   Leu Gln Phe Met Gly   Gln Ala Phe 
    33725                 33730                 33735             


Lys Ser   Ile His Glu Lys Val   Ser Lys Ile Ser Glu   Thr Lys Lys 
    33740                 33745                 33750             


Ser Asp   Gln Lys Thr Thr Glu   Ser Thr Val Thr Arg   Lys Thr Glu 
    33755                 33760                 33765             


Pro Lys   Ala Pro Glu Pro Ile   Ser Ser Lys Pro Val   Ile Val Thr 
    33770                 33775                 33780             


Gly Leu   Gln Asp Thr Thr Val   Ser Ser Asp Ser Val   Ala Lys Phe 
    33785                 33790                 33795             


Ala Val   Lys Ala Thr Gly Glu   Pro Arg Pro Thr Ala   Ile Trp Thr 
    33800                 33805                 33810             


Lys Asp   Gly Lys Ala Ile Thr   Gln Gly Gly Lys Tyr   Lys Leu Ser 
    33815                 33820                 33825             


Glu Asp   Lys Gly Gly Phe Phe   Leu Glu Ile His Lys   Thr Asp Thr 
    33830                 33835                 33840             


Ser Asp   Ser Gly Leu Tyr Thr   Cys Thr Val Lys Asn   Ser Ala Gly 
    33845                 33850                 33855             


Ser Val   Ser Ser Ser Cys Lys   Leu Thr Ile Lys Ala   Ile Lys Asp 
    33860                 33865                 33870             


Thr Glu   Ala Gln Lys Val Ser   Thr Gln Lys Thr Ser   Glu Ile Thr 
    33875                 33880                 33885             


Pro Gln   Lys Lys Ala Val Val   Gln Glu Glu Ile Ser   Gln Lys Ala 
    33890                 33895                 33900             


Leu Arg   Ser Glu Glu Ile Lys   Met Ser Glu Ala Lys   Ser Gln Glu 
    33905                 33910                 33915             


Lys Leu   Ala Leu Lys Glu Glu   Ala Ser Lys Val Leu   Ile Ser Glu 
    33920                 33925                 33930             


Glu Val   Lys Lys Ser Ala Ala   Thr Ser Leu Glu Lys   Ser Ile Val 
    33935                 33940                 33945             


His Glu   Glu Ile Thr Lys Thr   Ser Gln Ala Ser Glu   Glu Val Arg 
    33950                 33955                 33960             


Thr His   Ala Glu Ile Lys Ala   Phe Ser Thr Gln Met   Ser Ile Asn 
    33965                 33970                 33975             


Glu Gly   Gln Arg Leu Val Leu   Lys Ala Asn Ile Ala   Gly Ala Thr 
    33980                 33985                 33990             


Asp Val   Lys Trp Val Leu Asn   Gly Val Glu Leu Thr   Asn Ser Glu 
    33995                 34000                 34005             


Glu Tyr   Arg Tyr Gly Val Ser   Gly Ser Asp Gln Thr   Leu Thr Ile 
    34010                 34015                 34020             


Lys Gln   Ala Ser His Arg Asp   Glu Gly Ile Leu Thr   Cys Ile Ser 
    34025                 34030                 34035             


Lys Thr   Lys Glu Gly Ile Val   Lys Cys Gln Tyr Asp   Leu Thr Leu 
    34040                 34045                 34050             


Ser Lys   Glu Leu Ser Asp Ala   Pro Ala Phe Ile Ser   Gln Pro Arg 
    34055                 34060                 34065             


Ser Gln   Asn Ile Asn Glu Gly   Gln Asn Val Leu Phe   Thr Cys Glu 
    34070                 34075                 34080             


Ile Ser   Gly Glu Pro Ser Pro   Glu Ile Glu Trp Phe   Lys Asn Asn 
    34085                 34090                 34095             


Leu Pro   Ile Ser Ile Ser Ser   Asn Val Ser Ile Ser   Arg Ser Arg 
    34100                 34105                 34110             


Asn Val   Tyr Ser Leu Glu Ile   Arg Asn Ala Ser Val   Ser Asp Ser 
    34115                 34120                 34125             


Gly Lys   Tyr Thr Ile Lys Ala   Lys Asn Phe Arg Gly   Gln Cys Ser 
    34130                 34135                 34140             


Ala Thr   Ala Ser Leu Met Val   Leu Pro Leu Val Glu   Glu Pro Ser 
    34145                 34150                 34155             


Arg Glu   Val Val Leu Arg Thr   Ser Gly Asp Thr Ser   Leu Gln Gly 
    34160                 34165                 34170             


Ser Phe   Ser Ser Gln Ser Val   Gln Met Ser Ala Ser   Lys Gln Glu 
    34175                 34180                 34185             


Ala Ser   Phe Ser Ser Phe Ser   Ser Ser Ser Ala Ser   Ser Met Thr 
    34190                 34195                 34200             


Glu Met   Lys Phe Ala Ser Met   Ser Ala Gln Ser Met   Ser Ser Met 
    34205                 34210                 34215             


Gln Glu   Ser Phe Val Glu Met   Ser Ser Ser Ser Phe   Met Gly Ile 
    34220                 34225                 34230             


Ser Asn   Met Thr Gln Leu Glu   Ser Ser Thr Ser Lys   Met Leu Lys 
    34235                 34240                 34245             


Ala Gly   Ile Arg Gly Ile Pro   Pro Lys Ile Glu Ala   Leu Pro Ser 
    34250                 34255                 34260             


Asp Ile   Ser Ile Asp Glu Gly   Lys Val Leu Thr Val   Ala Cys Ala 
    34265                 34270                 34275             


Phe Thr   Gly Glu Pro Thr Pro   Glu Val Thr Trp Ser   Cys Gly Gly 
    34280                 34285                 34290             


Arg Lys   Ile His Ser Gln Glu   Gln Gly Arg Phe His   Ile Glu Asn 
    34295                 34300                 34305             


Thr Asp   Asp Leu Thr Thr Leu   Ile Ile Met Asp Val   Gln Lys Gln 
    34310                 34315                 34320             


Asp Gly   Gly Leu Tyr Thr Leu   Ser Leu Gly Asn Glu   Phe Gly Ser 
    34325                 34330                 34335             


Asp Ser   Ala Thr Val Asn Ile   His Ile Arg Ser Ile   
    34340                 34345                 34350 


<210> 7668
<211> 419
<212> PRT
<213> Homo sapiens

<400> 7668
Met Lys Leu Tyr Gln Thr Pro Leu Glu Leu Lys Leu Lys His Ser Thr
 1               5                  10                  15      
Val His Val Asp Glu Leu Cys Pro Leu Ile Val Pro Asn Leu Gly Val
            20                  25                  30          
Ala Val Ile His Asp Tyr Ala Asp Trp Val Lys Glu Ala Ser Gly Asp
        35                  40                  45              
Leu Pro Glu Ala Gln Ile Val Lys His Trp Ser Leu Thr Trp Thr Leu
    50                  55                  60                  
Cys Glu Ala Leu Trp Gly His Leu Lys Glu Leu Asp Ser Gln Leu Asn
65                  70                  75                  80  
Glu Pro Arg Glu Tyr Ile Gln Ile Leu Glu Arg Arg Arg Ala Phe Ser
                85                  90                  95      
Arg Trp Leu Ser Cys Thr Ala Thr Pro Gln Ile Glu Glu Glu Val Ser
            100                 105                 110         
Leu Thr Gln Lys Asn Ser Pro Val Glu Ala Val Phe Ser Tyr Leu Thr
        115                 120                 125             
Gly Lys Arg Ile Ser Glu Ala Cys Ser Leu Ala Gln Gln Ser Gly Asp
    130                 135                 140                 
His Arg Leu Ala Leu Leu Leu Ser Gln Phe Val Gly Ser Gln Ser Val
145                 150                 155                 160 
Arg Glu Leu Leu Thr Met Gln Leu Val Asp Trp His Gln Leu Gln Ala
                165                 170                 175     
Asp Ser Phe Ile Gln Asp Glu Arg Leu Arg Ile Phe Ala Leu Leu Ala
            180                 185                 190         
Gly Lys Pro Val Trp Gln Leu Ser Glu Lys Lys Gln Ile Asn Val Cys
        195                 200                 205             
Ser Gln Leu Asp Trp Lys Arg Ser Leu Ala Ile His Leu Trp Tyr Leu
    210                 215                 220                 
Leu Pro Pro Thr Ala Ser Ile Ser Arg Ala Leu Ser Met Tyr Glu Glu
225                 230                 235                 240 
Ala Phe Gln Asn Thr Ser Asp Ser Asp Arg Tyr Ala Cys Ser Pro Leu
                245                 250                 255     
Pro Ser Tyr Leu Glu Gly Ser Gly Cys Val Ile Ala Glu Glu Gln Asn
            260                 265                 270         
Ser Gln Thr Pro Leu Arg Asp Val Cys Phe His Leu Leu Lys Leu Tyr
        275                 280                 285             
Ser Asp Arg His Tyr Asp Leu Asn Gln Leu Leu Glu Pro Arg Ser Ile
    290                 295                 300                 
Thr Ala Asp Pro Leu Asp Tyr Arg Leu Ser Trp His Leu Trp Glu Val
305                 310                 315                 320 
Leu Arg Ala Leu Asn Tyr Thr His Leu Ser Ala Gln Cys Glu Gly Val
                325                 330                 335     
Leu Gln Val Thr Leu Ala Ser Leu Lys Val Arg Gly Ser Gly Ser Gly
            340                 345                 350         
Pro Ser Leu Ser Ser Cys Thr Leu Thr Thr Gln Ala Tyr Val Arg Arg
        355                 360                 365             
Leu Phe Glu Ser Cys Leu Pro Gly Thr Ala Ser Cys Trp Arg Pro Leu
    370                 375                 380                 
Asn Leu Gly Leu Lys Arg Leu Ser Leu Pro Arg Ser Ser Val Tyr Leu
385                 390                 395                 400 
Pro Asn Gly Ser Thr Arg Pro Lys Leu Cys Glu His Thr Trp Asn Leu
                405                 410                 415     
Thr Ser Thr
            


<210> 7669
<211> 417
<212> PRT
<213> Homo sapiens

<400> 7669
Ser Ser Ala His Gln Ser Leu Ser Gln Arg Ala His Trp Arg Arg Arg
 1               5                  10                  15      
Gly Ser Ile His Gln Pro Ala Pro Arg Leu Gln Asp Arg Ala Ser Val
            20                  25                  30          
Cys Met Gly Val Thr Gly Ala His Gly Phe Pro Cys Cys Gly Lys Gly
        35                  40                  45              
Ser Val Glu Val Ala Glu Met Arg Asp Asp Leu Ser Gln His Gln Ile
    50                  55                  60                  
Gln Glu Glu Gln Glu Leu Glu Ala Asp Met Leu Glu Gln Lys Pro Gln
65                  70                  75                  80  
Leu Gln Val Asp Leu Asp Leu Asp Pro Asp Pro Asp Pro Asp Pro Glu
                85                  90                  95      
Leu Glu Ile Gly Gln Val Pro Ala Leu Leu Glu Ser Glu Leu Tyr Pro
            100                 105                 110         
Ala Leu Lys Leu Glu Ala Glu Leu Asp Thr Glu Ala Asn Ser Asn Glu
        115                 120                 125             
Glu Ser Asp Phe Glu Glu Pro Met Gln Leu Val Cys Lys Ile Glu Ser
    130                 135                 140                 
Val His Ser Asn Met Gly Leu Pro Thr Pro Gln Thr Phe Arg Pro Trp
145                 150                 155                 160 
Ser Leu Asn Ser Asn Cys Arg Ser Phe Thr Glu Glu Asn His Val Ser
                165                 170                 175     
Ala Cys His His Ser Ile Ser Ala Gln Thr Ser Lys His Leu Phe Trp
            180                 185                 190         
Ala Asn Lys Leu Ile Gln Ala Ser Glu His Ser Leu Gln Arg Ala Ile
        195                 200                 205             
Asn Met Gln Leu Asn Asn Gly Ser Ala Gly Gln Pro Ile Arg Ser Pro
    210                 215                 220                 
Leu Arg Glu Ala Ile Pro Thr Asn Ala Leu Cys Ser Glu Glu Gln Leu
225                 230                 235                 240 
Gln Ile Pro Asp Ala His Ser Ala Pro Pro Thr Thr Ser Ser Gln Ala
                245                 250                 255     
Pro Ser Pro Leu Leu Ser Ser Asp Leu Pro Pro Pro Ile Asp Leu Thr
            260                 265                 270         
Glu Leu Ile Thr Phe Ala Ser Ser Leu Ala Met Ala Ser Ser Ser Arg
        275                 280                 285             
Met Asp Leu Pro Ser Leu Glu His Met Met Lys Ala Pro Pro Gln Glu
    290                 295                 300                 
Ala Leu Glu Pro Ser Thr Glu Pro Leu Leu Thr Thr Val Glu Glu Arg
305                 310                 315                 320 
Glu Pro Glu Asn His Ala Glu Thr Leu Pro Glu Lys Pro Arg Glu Ala
                325                 330                 335     
Arg Ala Pro Leu Lys Ser Trp Ser Gln Glu Asp Lys Asn Phe Ala Gln
            340                 345                 350         
Ser Tyr Phe Asp Phe Ser Lys Pro Gly Ile Lys Arg Ala Thr Ile Lys
        355                 360                 365             
Gly Gln Ile Gln Leu Leu Gln Pro Pro Ala Thr Ser Pro Leu Leu Gln
    370                 375                 380                 
Gly Ser Lys Glu Asp Ser Val Pro Pro Gly Lys Glu Lys Glu Asn Pro
385                 390                 395                 400 
Leu Leu Val Lys Ile His Phe Lys Leu Ser Ala Pro Thr Ile Pro Glu
                405                 410                 415     
Lys
    


<210> 7670
<211> 505
<212> PRT
<213> Homo sapiens

<400> 7670
Met Ser Glu Ser Lys Ala Lys Lys Ile Glu Ile Lys Asp Val Asp Gly
 1               5                  10                  15      
Gln Thr Leu Ser Lys Leu Ile Asp Tyr Ile Tyr Thr Ala Glu Ile Glu
            20                  25                  30          
Val Thr Glu Glu Asn Val Gln Val Leu Leu Pro Ala Ala Ser Leu Leu
        35                  40                  45              
Gln Leu Met Asp Val Arg Gln Asn Cys Cys Asp Phe Leu Gln Ser Gln
    50                  55                  60                  
Leu His Pro Thr Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp Val His
65                  70                  75                  80  
Thr Cys Thr Asp Leu Leu Gln Gln Ala Asn Ala Tyr Ala Glu Gln His
                85                  90                  95      
Phe Pro Glu Val Met Leu Gly Glu Glu Phe Leu Ser Leu Ser Leu Asp
            100                 105                 110         
Gln Val Cys Ser Leu Ile Ser Ser Asp Lys Leu Thr Val Ser Ser Glu
        115                 120                 125             
Glu Lys Val Phe Glu Ala Val Ile Ser Trp Ile Asn Tyr Glu Lys Glu
    130                 135                 140                 
Thr Arg Leu Glu His Met Ala Lys Leu Met Glu His Val Arg Leu Pro
145                 150                 155                 160 
Leu Leu Pro Arg Asp Tyr Leu Val Gln Thr Val Glu Glu Glu Ala Leu
                165                 170                 175     
Ile Lys Asn Asn Asn Thr Cys Lys Asp Phe Leu Ile Glu Ala Met Lys
            180                 185                 190         
Tyr His Leu Leu Pro Leu Asp Gln Arg Leu Leu Ile Lys Asn Pro Arg
        195                 200                 205             
Thr Lys Pro Arg Thr Pro Val Ser Leu Pro Lys Val Met Ile Val Val
    210                 215                 220                 
Gly Gly Gln Ala Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr Asp Phe
225                 230                 235                 240 
Glu Glu Asp Arg Trp Asp Gln Ile Ala Glu Leu Pro Ser Arg Arg Cys
                245                 250                 255     
Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val Gly Gly
            260                 265                 270         
Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Val Tyr Asp Gly Val
        275                 280                 285             
Lys Asp Gln Trp Thr Ser Ile Ala Ser Met Gln Glu Arg Arg Ser Thr
    290                 295                 300                 
Leu Gly Ala Ala Val Leu Asn Asp Leu Leu Tyr Ala Val Gly Gly Phe
305                 310                 315                 320 
Asp Gly Ser Thr Gly Leu Ala Ser Val Glu Ala Tyr Ser Tyr Lys Thr
                325                 330                 335     
Asn Glu Trp Phe Phe Val Ala Pro Met Asn Thr Arg Arg Ser Ser Val
            340                 345                 350         
Gly Val Gly Val Val Glu Gly Lys Leu Tyr Ala Val Gly Gly Tyr Asp
        355                 360                 365             
Gly Ala Ser Arg Gln Cys Leu Ser Thr Val Glu Gln Tyr Asn Pro Ala
    370                 375                 380                 
Thr Asn Glu Trp Ile Tyr Val Ala Asp Met Ser Thr Arg Arg Ser Gly
385                 390                 395                 400 
Ala Gly Val Gly Val Leu Ser Gly Gln Leu Tyr Ala Thr Gly Gly His
                405                 410                 415     
Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro Gly Thr
            420                 425                 430         
Asn Thr Trp Lys Gln Val Ala Asp Met Asn Met Cys Arg Arg Asn Ala
        435                 440                 445             
Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly Asp Asp
    450                 455                 460                 
Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Val Thr Asp
465                 470                 475                 480 
Lys Trp Thr Leu Leu Pro Thr Asn Met Ser Thr Gly Arg Ser Tyr Ala
                485                 490                 495     
Gly Val Ala Val Ile His Lys Ser Leu
            500                 505 


<210> 7671
<211> 587
<212> PRT
<213> Homo sapiens

<400> 7671
Met Glu Gly Glu Ser Val Lys Leu Ser Ser Gln Thr Leu Ile Gln Ala
 1               5                  10                  15      
Gly Asp Asp Glu Lys Asn Gln Arg Thr Ile Thr Val Asn Pro Ala His
            20                  25                  30          
Met Gly Lys Ala Phe Lys Val Met Asn Glu Leu Arg Ser Lys Gln Leu
        35                  40                  45              
Leu Cys Asp Val Met Ile Val Ala Glu Asp Val Glu Ile Glu Ala His
    50                  55                  60                  
Arg Val Val Leu Ala Ala Cys Ser Pro Tyr Phe Cys Ala Met Phe Thr
65                  70                  75                  80  
Gly Asp Met Ser Glu Ser Lys Ala Lys Lys Ile Glu Ile Lys Asp Val
                85                  90                  95      
Asp Gly Gln Thr Leu Ser Lys Leu Ile Asp Tyr Ile Tyr Thr Ala Glu
            100                 105                 110         
Ile Glu Val Thr Glu Glu Asn Val Gln Val Leu Leu Pro Ala Ala Ser
        115                 120                 125             
Leu Leu Gln Leu Met Asp Val Arg Gln Asn Cys Cys Asp Phe Leu Gln
    130                 135                 140                 
Ser Gln Leu His Pro Thr Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp
145                 150                 155                 160 
Val His Thr Cys Thr Asp Leu Leu Gln Gln Ala Asn Ala Tyr Ala Glu
                165                 170                 175     
Gln His Phe Pro Glu Val Met Leu Gly Glu Glu Phe Leu Ser Leu Ser
            180                 185                 190         
Leu Asp Gln Val Cys Ser Leu Ile Ser Ser Asp Lys Leu Thr Val Ser
        195                 200                 205             
Ser Glu Glu Lys Val Phe Glu Ala Val Ile Ser Trp Ile Asn Tyr Glu
    210                 215                 220                 
Lys Glu Thr Arg Leu Glu His Met Ala Lys Leu Met Glu His Val Arg
225                 230                 235                 240 
Leu Pro Leu Leu Pro Arg Asp Tyr Leu Val Gln Thr Val Glu Glu Glu
                245                 250                 255     
Ala Leu Ile Lys Asn Asn Asn Thr Cys Lys Asp Phe Leu Ile Glu Ala
            260                 265                 270         
Met Lys Tyr His Leu Leu Pro Leu Asp Gln Arg Leu Leu Ile Lys Asn
        275                 280                 285             
Pro Arg Thr Lys Pro Arg Thr Pro Val Ser Leu Pro Lys Val Met Ile
    290                 295                 300                 
Val Val Gly Gly Gln Ala Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr
305                 310                 315                 320 
Asp Phe Glu Glu Asp Arg Trp Asp Gln Ile Ala Glu Leu Pro Ser Arg
                325                 330                 335     
Arg Cys Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val
            340                 345                 350         
Gly Gly Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Val Tyr Asp
        355                 360                 365             
Gly Val Lys Asp Gln Trp Thr Ser Ile Ala Ser Met Gln Glu Arg Arg
    370                 375                 380                 
Ser Thr Leu Gly Ala Ala Val Leu Asn Asp Leu Leu Tyr Ala Val Gly
385                 390                 395                 400 
Gly Phe Asp Gly Ser Thr Gly Leu Ala Ser Val Glu Ala Tyr Ser Tyr
                405                 410                 415     
Lys Thr Asn Glu Trp Phe Phe Val Ala Pro Met Asn Thr Arg Arg Ser
            420                 425                 430         
Ser Val Gly Val Gly Val Val Glu Gly Lys Leu Tyr Ala Val Gly Gly
        435                 440                 445             
Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser Thr Val Glu Gln Tyr Asn
    450                 455                 460                 
Pro Ala Thr Asn Glu Trp Ile Tyr Val Ala Asp Met Ser Thr Arg Arg
465                 470                 475                 480 
Ser Gly Ala Gly Val Gly Val Leu Ser Gly Gln Leu Tyr Ala Thr Gly
                485                 490                 495     
Gly His Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro
            500                 505                 510         
Gly Thr Asn Thr Trp Lys Gln Val Ala Asp Met Asn Met Cys Arg Arg
        515                 520                 525             
Asn Ala Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly
    530                 535                 540                 
Asp Asp Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Val
545                 550                 555                 560 
Thr Asp Lys Trp Thr Leu Leu Pro Thr Asn Met Ser Thr Gly Arg Ser
                565                 570                 575     
Tyr Ala Gly Val Ala Val Ile His Lys Ser Leu
            580                 585         


<210> 7672
<211> 555
<212> PRT
<213> Homo sapiens

<400> 7672
Met Gly Lys Ala Phe Lys Val Met Asn Glu Leu Arg Ser Lys Gln Leu
 1               5                  10                  15      
Leu Cys Asp Val Met Ile Val Ala Glu Asp Val Glu Ile Glu Ala His
            20                  25                  30          
Arg Val Val Leu Ala Ala Cys Ser Pro Tyr Phe Cys Ala Met Phe Thr
        35                  40                  45              
Gly Asp Met Ser Glu Ser Lys Ala Lys Lys Ile Glu Ile Lys Asp Val
    50                  55                  60                  
Asp Gly Gln Thr Leu Ser Lys Leu Ile Asp Tyr Ile Tyr Thr Ala Glu
65                  70                  75                  80  
Ile Glu Val Thr Glu Glu Asn Val Gln Val Leu Leu Pro Ala Ala Ser
                85                  90                  95      
Leu Leu Gln Leu Met Asp Val Arg Gln Asn Cys Cys Asp Phe Leu Gln
            100                 105                 110         
Ser Gln Leu His Pro Thr Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp
        115                 120                 125             
Val His Thr Cys Thr Asp Leu Leu Gln Gln Ala Asn Ala Tyr Ala Glu
    130                 135                 140                 
Gln His Phe Pro Glu Val Met Leu Gly Glu Glu Phe Leu Ser Leu Ser
145                 150                 155                 160 
Leu Asp Gln Val Cys Ser Leu Ile Ser Ser Asp Lys Leu Thr Val Ser
                165                 170                 175     
Ser Glu Glu Lys Val Phe Glu Ala Val Ile Ser Trp Ile Asn Tyr Glu
            180                 185                 190         
Lys Glu Thr Arg Leu Glu His Met Ala Lys Leu Met Glu His Val Arg
        195                 200                 205             
Leu Pro Leu Leu Pro Arg Asp Tyr Leu Val Gln Thr Val Glu Glu Glu
    210                 215                 220                 
Ala Leu Ile Lys Asn Asn Asn Thr Cys Lys Asp Phe Leu Ile Glu Ala
225                 230                 235                 240 
Met Lys Tyr His Leu Leu Pro Leu Asp Gln Arg Leu Leu Ile Lys Asn
                245                 250                 255     
Pro Arg Thr Lys Pro Arg Thr Pro Val Ser Leu Pro Lys Val Met Ile
            260                 265                 270         
Val Val Gly Gly Gln Ala Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr
        275                 280                 285             
Asp Phe Glu Glu Asp Arg Trp Asp Gln Ile Ala Glu Leu Pro Ser Arg
    290                 295                 300                 
Arg Cys Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val
305                 310                 315                 320 
Gly Gly Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Val Tyr Asp
                325                 330                 335     
Gly Val Lys Asp Gln Trp Thr Ser Ile Ala Ser Met Gln Glu Arg Arg
            340                 345                 350         
Ser Thr Leu Gly Ala Ala Val Leu Asn Asp Leu Leu Tyr Ala Val Gly
        355                 360                 365             
Gly Phe Asp Gly Ser Thr Gly Leu Ala Ser Val Glu Ala Tyr Ser Tyr
    370                 375                 380                 
Lys Thr Asn Glu Trp Phe Phe Val Ala Pro Met Asn Thr Arg Arg Ser
385                 390                 395                 400 
Ser Val Gly Val Gly Val Val Glu Gly Lys Leu Tyr Ala Val Gly Gly
                405                 410                 415     
Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser Thr Val Glu Gln Tyr Asn
            420                 425                 430         
Pro Ala Thr Asn Glu Trp Ile Tyr Val Ala Asp Met Ser Thr Arg Arg
        435                 440                 445             
Ser Gly Ala Gly Val Gly Val Leu Ser Gly Gln Leu Tyr Ala Thr Gly
    450                 455                 460                 
Gly His Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro
465                 470                 475                 480 
Gly Thr Asn Thr Trp Lys Gln Val Ala Asp Met Asn Met Cys Arg Arg
                485                 490                 495     
Asn Ala Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly
            500                 505                 510         
Asp Asp Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Val
        515                 520                 525             
Thr Asp Lys Trp Thr Leu Leu Pro Thr Asn Met Ser Thr Gly Arg Ser
    530                 535                 540                 
Tyr Ala Gly Val Ala Val Ile His Lys Ser Leu
545                 550                 555 


<210> 7673
<211> 452
<212> PRT
<213> Homo sapiens

<400> 7673
Met Val Ile Ile Ile Phe Phe Thr Arg Thr Gly Ser Pro Ala Leu Thr
 1               5                  10                  15      
Lys Gln Gln Gln Lys Lys Gly Thr Met Ala Leu Ser Gly Asn Cys Ser
            20                  25                  30          
Arg Tyr Tyr Pro Arg Glu Gln Gly Ser Ala Val Pro Asn Ser Phe Pro
        35                  40                  45              
Glu Val Val Glu Leu Asn Val Gly Gly Gln Val Tyr Phe Thr Arg His
    50                  55                  60                  
Ser Thr Leu Ile Ser Ile Pro His Ser Leu Leu Trp Lys Met Phe Ser
65                  70                  75                  80  
Pro Lys Arg Asp Thr Ala Asn Asp Leu Ala Lys Asp Ser Lys Gly Arg
                85                  90                  95      
Phe Phe Ile Asp Arg Asp Gly Phe Leu Phe Arg Tyr Ile Leu Asp Tyr
            100                 105                 110         
Leu Arg Asp Arg Gln Val Val Leu Pro Asp His Phe Pro Glu Lys Gly
        115                 120                 125             
Arg Leu Lys Arg Glu Ala Glu Tyr Phe Gln Leu Pro Asp Leu Val Lys
    130                 135                 140                 
Leu Leu Thr Pro Asp Glu Ile Lys Gln Ser Pro Asp Glu Phe Cys His
145                 150                 155                 160 
Ser Asp Phe Glu Asp Ala Ser Gln Gly Ser Asp Thr Arg Ile Cys Pro
                165                 170                 175     
Pro Ser Ser Leu Leu Pro Ala Asp Arg Lys Trp Gly Phe Ile Thr Val
            180                 185                 190         
Gly Tyr Arg Gly Ser Cys Thr Leu Gly Arg Glu Gly Gln Ala Asp Ala
        195                 200                 205             
Lys Phe Arg Arg Val Pro Arg Ile Leu Val Cys Gly Arg Ile Ser Leu
    210                 215                 220                 
Ala Lys Glu Val Phe Gly Glu Thr Leu Asn Glu Ser Arg Asp Pro Asp
225                 230                 235                 240 
Arg Ala Pro Glu Arg Tyr Thr Ser Arg Phe Tyr Leu Lys Phe Lys His
                245                 250                 255     
Leu Glu Arg Ala Phe Asp Met Leu Ser Glu Cys Gly Phe His Met Val
            260                 265                 270         
Ala Cys Asn Ser Ser Val Thr Ala Ser Phe Ile Asn Gln Tyr Thr Asp
        275                 280                 285             
Asp Lys Ile Trp Ser Ser Tyr Thr Glu Tyr Val Phe Tyr Arg Glu Pro
    290                 295                 300                 
Ser Arg Trp Ser Pro Ser His Cys Asp Cys Cys Cys Lys Asn Gly Lys
305                 310                 315                 320 
Gly Asp Lys Glu Gly Glu Ser Gly Thr Ser Cys Asn Asp Leu Ser Thr
                325                 330                 335     
Ser Ser Cys Asp Ser Gln Ser Glu Ala Ser Ser Pro Gln Glu Thr Val
            340                 345                 350         
Ile Cys Gly Pro Val Thr Arg Gln Thr Asn Ile Gln Thr Leu Asp Arg
        355                 360                 365             
Pro Ile Lys Lys Gly Pro Val Gln Leu Ile Gln Gln Ser Glu Met Arg
    370                 375                 380                 
Arg Lys Ser Asp Leu Leu Arg Thr Leu Thr Ser Gly Ser Arg Glu Ser
385                 390                 395                 400 
Asn Met Ser Ser Lys Lys Lys Ala Val Lys Glu Lys Leu Ser Ile Glu
                405                 410                 415     
Glu Glu Leu Glu Lys Cys Ile Gln Asp Phe Leu Lys Ile Lys Ile Pro
            420                 425                 430         
Asp Arg Phe Pro Glu Arg Lys His Pro Trp Gln Ser Glu Leu Leu Arg
        435                 440                 445             
Lys Tyr His Leu
    450         


<210> 7674
<211> 2971
<212> PRT
<213> Homo sapiens

<400> 7674
Met Ala Lys Asp Val Arg Gln Phe Trp Ser Asn Val Glu Lys Val Val
 1               5                  10                  15      
Gln Phe Lys Gln Gln Ser Arg Leu Glu Glu Lys Arg Lys Lys Ala Leu
            20                  25                  30          
Asp Leu His Leu Asp Phe Ile Val Gly Gln Thr Glu Lys Tyr Ser Asp
        35                  40                  45              
Leu Leu Ser Gln Ser Leu Asn Gln Pro Leu Thr Ser Ser Lys Ala Gly
    50                  55                  60                  
Ser Ser Pro Cys Leu Gly Ser Ser Ser Ala Ala Ser Ser Pro Pro Pro
65                  70                  75                  80  
Pro Ala Ser Arg Leu Asp Asp Glu Asp Gly Asp Phe Gln Pro Gln Glu
                85                  90                  95      
Asp Glu Glu Glu Asp Asp Glu Glu Thr Ile Glu Val Glu Glu Gln Gln
            100                 105                 110         
Glu Gly Asn Asp Ala Glu Ala Gln Arg Arg Glu Ile Glu Leu Leu Arg
        115                 120                 125             
Arg Glu Gly Glu Leu Pro Leu Glu Glu Leu Leu Arg Ser Leu Pro Pro
    130                 135                 140                 
Gln Leu Leu Glu Gly Pro Ser Ser Pro Ser Gln Thr Pro Ser Ser His
145                 150                 155                 160 
Asp Ser Asp Thr Arg Asp Gly Pro Glu Glu Gly Ala Glu Glu Glu Pro
                165                 170                 175     
Pro Gln Val Leu Glu Ile Lys Pro Pro Pro Ser Ala Val Thr Gln Arg
            180                 185                 190         
Asn Lys Gln Pro Trp His Pro Asp Glu Asp Asp Glu Glu Phe Thr Ala
        195                 200                 205             
Asn Glu Glu Glu Ala Glu Asp Glu Glu Asp Thr Ile Ala Ala Glu Glu
    210                 215                 220                 
Gln Leu Glu Gly Glu Val Asp His Ala Met Glu Leu Ser Glu Leu Ala
225                 230                 235                 240 
Arg Glu Gly Glu Leu Ser Met Glu Glu Leu Leu Gln Gln Tyr Ala Gly
                245                 250                 255     
Ala Tyr Ala Pro Gly Ser Gly Ser Ser Glu Asp Glu Asp Glu Asp Glu
            260                 265                 270         
Val Asp Ala Asn Ser Ser Asp Cys Glu Pro Glu Gly Pro Val Glu Ala
        275                 280                 285             
Glu Glu Pro Pro Gln Glu Asp Ser Ser Ser Gln Ser Asp Ser Val Glu
    290                 295                 300                 
Asp Arg Ser Glu Asp Glu Glu Asp Glu His Ser Glu Glu Glu Glu Thr
305                 310                 315                 320 
Ser Gly Ser Ser Ala Ser Glu Glu Ser Glu Ser Glu Glu Ser Glu Asp
                325                 330                 335     
Ala Gln Ser Gln Ser Gln Ala Asp Glu Glu Glu Glu Asp Asp Asp Phe
            340                 345                 350         
Gly Val Glu Tyr Leu Leu Ala Arg Asp Glu Glu Gln Ser Glu Ala Asp
        355                 360                 365             
Ala Gly Ser Gly Pro Pro Thr Pro Gly Pro Thr Thr Leu Gly Pro Lys
    370                 375                 380                 
Lys Glu Ile Thr Asp Ile Ala Ala Ala Ala Glu Ser Leu Gln Pro Lys
385                 390                 395                 400 
Gly Tyr Thr Leu Ala Thr Thr Gln Val Lys Thr Pro Ile Pro Leu Leu
                405                 410                 415     
Leu Arg Gly Gln Leu Arg Glu Tyr Gln His Ile Gly Leu Asp Trp Leu
            420                 425                 430         
Val Thr Met Tyr Glu Lys Lys Leu Asn Gly Ile Leu Ala Asp Glu Met
        435                 440                 445             
Gly Leu Gly Lys Thr Ile Gln Thr Ile Ser Leu Leu Ala His Leu Ala
    450                 455                 460                 
Cys Glu Lys Gly Asn Trp Gly Pro His Leu Ile Ile Val Pro Thr Ser
465                 470                 475                 480 
Val Met Leu Asn Trp Glu Met Glu Leu Lys Arg Trp Cys Pro Ser Phe
                485                 490                 495     
Lys Ile Leu Thr Tyr Tyr Gly Ala Gln Lys Glu Arg Lys Leu Lys Arg
            500                 505                 510         
Gln Gly Trp Thr Lys Pro Asn Ala Phe His Val Cys Ile Thr Ser Tyr
        515                 520                 525             
Lys Leu Val Leu Gln Asp His Gln Ala Phe Arg Arg Lys Asn Trp Arg
    530                 535                 540                 
Tyr Leu Ile Leu Asp Glu Ala Gln Asn Ile Lys Asn Phe Lys Ser Gln
545                 550                 555                 560 
Arg Trp Gln Ser Leu Leu Asn Phe Asn Ser Gln Arg Arg Leu Leu Leu
                565                 570                 575     
Thr Gly Thr Pro Leu Gln Asn Ser Leu Met Glu Leu Trp Ser Leu Met
            580                 585                 590         
His Phe Leu Met Pro His Val Phe Gln Ser His Arg Glu Phe Lys Glu
        595                 600                 605             
Trp Phe Ser Asn Pro Leu Thr Gly Met Ile Glu Gly Ser Gln Glu Tyr
    610                 615                 620                 
Asn Glu Gly Leu Val Lys Arg Leu His Lys Val Leu Arg Pro Phe Leu
625                 630                 635                 640 
Leu Arg Arg Val Lys Val Asp Val Glu Lys Gln Met Pro Lys Lys Tyr
                645                 650                 655     
Glu His Val Ile Arg Cys Arg Leu Ser Lys Arg Gln Arg Cys Leu Tyr
            660                 665                 670         
Asp Asp Phe Met Ala Gln Thr Thr Thr Lys Glu Thr Leu Ala Thr Gly
        675                 680                 685             
His Phe Met Ser Val Ile Asn Ile Leu Met Gln Leu Arg Lys Val Cys
    690                 695                 700                 
Asn His Pro Asn Leu Phe Asp Pro Arg Pro Val Thr Ser Pro Phe Ile
705                 710                 715                 720 
Thr Pro Gly Ile Cys Phe Ser Thr Ala Ser Leu Val Leu Arg Ala Thr
                725                 730                 735     
Asp Val His Pro Leu Gln Arg Ile Asp Met Gly Arg Phe Asp Leu Ile
            740                 745                 750         
Gly Leu Glu Gly Arg Val Ser Arg Tyr Glu Ala Asp Thr Phe Leu Pro
        755                 760                 765             
Arg His Arg Leu Ser Arg Arg Val Leu Leu Glu Val Ala Thr Ala Pro
    770                 775                 780                 
Asp Pro Pro Pro Arg Pro Lys Pro Val Lys Met Lys Val Asn Arg Met
785                 790                 795                 800 
Leu Gln Pro Val Pro Lys Gln Glu Gly Arg Thr Val Val Val Val Asn
                805                 810                 815     
Asn Pro Arg Ala Pro Leu Gly Pro Val Pro Val Arg Pro Pro Pro Gly
            820                 825                 830         
Pro Glu Leu Ser Ala Gln Pro Thr Pro Gly Pro Val Pro Gln Val Leu
        835                 840                 845             
Pro Ala Ser Leu Met Val Ser Ala Ser Pro Ala Gly Pro Pro Leu Ile
    850                 855                 860                 
Pro Ala Ser Arg Pro Pro Gly Pro Val Leu Leu Pro Pro Leu Gln Pro
865                 870                 875                 880 
Asn Ser Gly Ser Leu Pro Gln Val Leu Pro Ser Pro Leu Gly Val Leu
                885                 890                 895     
Ser Gly Thr Ser Arg Pro Pro Thr Pro Thr Leu Ser Leu Lys Pro Thr
            900                 905                 910         
Pro Pro Ala Pro Val Arg Leu Ser Pro Ala Pro Pro Pro Gly Ser Ser
        915                 920                 925             
Ser Leu Leu Lys Pro Leu Thr Val Pro Pro Gly Tyr Thr Phe Pro Pro
    930                 935                 940                 
Ala Ala Ala Thr Thr Thr Ser Thr Thr Thr Ala Thr Ala Thr Thr Thr
945                 950                 955                 960 
Ala Val Pro Ala Pro Thr Pro Ala Pro Gln Arg Leu Ile Leu Ser Pro
                965                 970                 975     
Asp Met Gln Ala Arg Leu Pro Ser Gly Glu Val Val Ser Ile Gly Gln
            980                 985                 990         
Leu Ala Ser Leu Ala Gln Arg Pro Val Ala Asn Ala Gly Gly Ser Lys
        995                 1000                1005            
Pro Leu Thr Phe Gln Ile Gln Gly Asn Lys Leu Thr Leu Thr Gly Ala
    1010                1015                1020                
Gln Val Arg Gln Leu Ala Val Gly Gln Pro Arg Pro Leu Gln Met Pro
1025                1030                1035                1040
Pro Thr Met Val Asn Asn Thr Gly Val Val Lys Ile Val Val Arg Gln
                1045                1050                1055    
Ala Pro Arg Asp Gly Leu Thr Pro Val Pro Pro Leu Ala Pro Ala Pro
            1060                1065                1070        
Arg Pro Pro Ser Ser Gly Leu Pro Ala Val Leu Asn Pro Arg Pro Thr
        1075                1080                1085            
Leu Thr Pro Gly Arg Leu Pro Thr Pro Thr Leu Gly Thr Ala Arg Ala
    1090                1095                1100                
Pro Met Pro Thr Pro Thr Leu Val Arg Pro Leu Leu Lys Leu Val His
1105                1110                1115                1120
Ser Pro Ser Pro Glu Val Ser Ala Ser Ala Pro Gly Ala Ala Pro Leu
                1125                1130                1135    
Thr Ile Ser Ser Pro Leu His Val Pro Ser Ser Leu Pro Gly Pro Ala
            1140                1145                1150        
Ser Ser Pro Met Pro Ile Pro Asn Ser Ser Pro Leu Ala Ser Pro Val
        1155                1160                1165            
Ser Ser Thr Val Ser Val Pro Leu Ser Ser Ser Leu Pro Ile Ser Val
    1170                1175                1180                
Pro Thr Thr Leu Pro Ala Pro Ala Ser Ala Pro Leu Thr Ile Pro Ile
1185                1190                1195                1200
Ser Ala Pro Leu Thr Val Ser Ala Ser Gly Pro Ala Leu Leu Thr Ser
                1205                1210                1215    
Val Thr Pro Pro Leu Ala Pro Val Val Pro Ala Ala Pro Gly Pro Pro
            1220                1225                1230        
Ser Leu Gln Pro Ser Gly Ala Ser Pro Ser Ala Ser Ala Leu Thr Leu
        1235                1240                1245            
Gly Leu Ala Thr Ala Pro Ser Leu Ser Ser Ser Gln Thr Pro Gly His
    1250                1255                1260                
Pro Leu Leu Leu Ala Pro Thr Ser Ser His Val Pro Gly Leu Asn Ser
1265                1270                1275                1280
Thr Val Ala Pro Ala Cys Ser Pro Val Leu Val Pro Ala Ser Ala Leu
                1285                1290                1295    
Ala Ser Pro Phe Pro Ser Ala Pro Asn Pro Ala Pro Ala Gln Ala Ser
            1300                1305                1310        
Leu Leu Ala Pro Ala Ser Ser Ala Ser Gln Ala Leu Ala Thr Pro Leu
        1315                1320                1325            
Ala Pro Met Ala Ala Pro Gln Thr Ala Ile Leu Ala Pro Ser Pro Ala
    1330                1335                1340                
Pro Pro Leu Ala Pro Leu Pro Val Leu Ala Pro Ser Pro Gly Ala Ala
1345                1350                1355                1360
Pro Val Leu Ala Ser Ser Gln Thr Pro Val Pro Val Met Ala Pro Ser
                1365                1370                1375    
Ser Thr Pro Gly Thr Ser Leu Ala Ser Ala Ser Pro Val Pro Ala Pro
            1380                1385                1390        
Thr Pro Val Leu Ala Pro Ser Ser Thr Gln Thr Met Leu Pro Ala Pro
        1395                1400                1405            
Val Pro Ser Pro Leu Pro Ser Pro Ala Ser Thr Gln Thr Leu Ala Leu
    1410                1415                1420                
Ala Pro Ala Leu Ala Pro Thr Leu Gly Gly Ser Ser Pro Ser Gln Thr
1425                1430                1435                1440
Leu Ser Leu Gly Thr Gly Asn Pro Gln Gly Pro Phe Pro Thr Gln Thr
                1445                1450                1455    
Leu Ser Leu Thr Pro Ala Ser Ser Leu Val Pro Thr Pro Ala Gln Thr
            1460                1465                1470        
Leu Ser Leu Ala Pro Gly Pro Pro Leu Gly Pro Thr Gln Thr Leu Ser
        1475                1480                1485            
Leu Ala Pro Ala Pro Pro Leu Ala Pro Ala Ser Pro Val Gly Pro Ala
    1490                1495                1500                
Pro Ala His Thr Leu Thr Leu Ala Pro Ala Ser Ser Ser Ala Ser Leu
1505                1510                1515                1520
Leu Ala Pro Ala Ser Val Gln Thr Leu Thr Leu Ser Pro Ala Pro Val
                1525                1530                1535    
Pro Thr Leu Gly Pro Ala Ala Ala Gln Thr Leu Ala Leu Ala Pro Ala
            1540                1545                1550        
Ser Thr Gln Ser Pro Ala Ser Gln Ala Ser Ser Leu Val Val Ser Ala
        1555                1560                1565            
Ser Gly Ala Ala Pro Leu Pro Val Thr Met Val Ser Arg Leu Pro Val
    1570                1575                1580                
Ser Lys Asp Glu Pro Asp Thr Leu Thr Leu Arg Ser Gly Pro Pro Ser
1585                1590                1595                1600
Pro Pro Ser Thr Ala Thr Ser Phe Gly Gly Pro Arg Pro Arg Arg Gln
                1605                1610                1615    
Pro Pro Pro Pro Pro Arg Ser Pro Phe Tyr Leu Asp Ser Leu Glu Glu
            1620                1625                1630        
Lys Arg Lys Arg Gln Arg Ser Glu Arg Leu Glu Arg Ile Phe Gln Leu
        1635                1640                1645            
Ser Glu Ala His Gly Ala Leu Ala Pro Val Tyr Gly Thr Glu Val Leu
    1650                1655                1660                
Asp Phe Cys Thr Leu Pro Gln Pro Val Ala Ser Pro Ile Gly Pro Arg
1665                1670                1675                1680
Ser Pro Gly Pro Ser His Pro Thr Phe Trp Thr Tyr Thr Glu Ala Ala
                1685                1690                1695    
His Arg Ala Val Leu Phe Pro Gln Gln Arg Leu Asp Gln Leu Ser Glu
            1700                1705                1710        
Ile Ile Glu Arg Phe Ile Phe Val Met Pro Pro Val Glu Ala Pro Pro
        1715                1720                1725            
Pro Ser Leu His Ala Cys His Pro Pro Pro Trp Leu Ala Pro Arg Gln
    1730                1735                1740                
Ala Ala Phe Gln Glu Gln Leu Ala Ser Glu Leu Trp Pro Arg Ala Arg
1745                1750                1755                1760
Pro Leu His Arg Ile Val Cys Asn Met Arg Thr Gln Phe Pro Asp Leu
                1765                1770                1775    
Arg Leu Ile Gln Tyr Asp Cys Gly Lys Leu Gln Thr Leu Ala Val Leu
            1780                1785                1790        
Leu Arg Gln Leu Lys Ala Glu Gly His Arg Val Leu Ile Phe Thr Gln
        1795                1800                1805            
Met Thr Arg Met Leu Asp Val Leu Glu Gln Phe Leu Thr Tyr His Gly
    1810                1815                1820                
His Leu Tyr Leu Arg Leu Asp Gly Ser Thr Arg Val Glu Gln Arg Gln
1825                1830                1835                1840
Ala Leu Met Glu Arg Phe Asn Ala Asp Lys Arg Ile Phe Cys Phe Ile
                1845                1850                1855    
Leu Ser Thr Arg Ser Gly Gly Val Gly Val Asn Leu Thr Gly Ala Asp
            1860                1865                1870        
Thr Val Val Phe Tyr Asp Ser Asp Trp Asn Pro Thr Met Asp Ala Gln
        1875                1880                1885            
Ala Gln Asp Arg Cys His Arg Ile Gly Gln Thr Arg Asp Val His Ile
    1890                1895                1900                
Tyr Arg Leu Ile Ser Glu Arg Thr Val Glu Glu Asn Ile Leu Lys Lys
1905                1910                1915                1920
Ala Asn Gln Lys Arg Met Leu Gly Asp Met Ala Ile Glu Gly Gly Asn
                1925                1930                1935    
Phe Thr Thr Ala Tyr Phe Lys Gln Gln Thr Ile Arg Glu Leu Phe Asp
            1940                1945                1950        
Met Pro Leu Glu Glu Pro Ser Ser Ser Ser Val Pro Ser Ala Pro Glu
        1955                1960                1965            
Glu Glu Glu Glu Thr Val Ala Ser Lys Gln Thr His Ile Leu Glu Gln
    1970                1975                1980                
Ala Leu Cys Arg Ala Glu Asp Glu Glu Asp Ile Arg Ala Ala Thr Gln
1985                1990                1995                2000
Ala Lys Ala Glu Gln Val Ala Glu Leu Ala Glu Phe Asn Glu Asn Asp
                2005                2010                2015    
Gly Phe Pro Ala Gly Glu Gly Glu Glu Ala Gly Arg Pro Gly Ala Glu
            2020                2025                2030        
Asp Glu Glu Met Ser Arg Ala Glu Gln Glu Ile Ala Ala Leu Val Glu
        2035                2040                2045            
Gln Leu Thr Pro Ile Glu Arg Tyr Ala Met Lys Phe Leu Glu Ala Ser
    2050                2055                2060                
Leu Glu Glu Val Ser Arg Glu Glu Leu Lys Gln Ala Glu Glu Gln Val
2065                2070                2075                2080
Glu Ala Ala Arg Lys Asp Leu Asp Gln Ala Lys Glu Glu Val Phe Arg
                2085                2090                2095    
Leu Pro Gln Glu Glu Glu Glu Gly Pro Gly Ala Gly Asp Glu Ser Ser
            2100                2105                2110        
Cys Gly Thr Gly Gly Gly Thr His Arg Arg Ser Lys Lys Ala Lys Ala
        2115                2120                2125            
Pro Glu Arg Pro Gly Thr Arg Val Ser Glu Arg Leu Arg Gly Ala Arg
    2130                2135                2140                
Ala Glu Thr Gln Gly Ala Asn His Thr Pro Val Ile Ser Ala His Gln
2145                2150                2155                2160
Thr Arg Ser Thr Thr Thr Pro Pro Arg Cys Ser Pro Ala Arg Glu Arg
                2165                2170                2175    
Val Pro Arg Pro Ala Pro Arg Pro Arg Pro Thr Pro Ala Ser Ala Pro
            2180                2185                2190        
Ala Ala Ile Pro Ala Leu Val Pro Val Pro Val Ser Ala Pro Val Pro
        2195                2200                2205            
Ile Ser Ala Pro Asn Pro Ile Thr Ile Leu Pro Val His Ile Leu Pro
    2210                2215                2220                
Ser Pro Pro Pro Pro Ser Gln Ile Pro Pro Cys Ser Ser Pro Ala Cys
2225                2230                2235                2240
Thr Pro Pro Pro Ala Cys Thr Pro Pro Pro Ala His Thr Pro Pro Pro
                2245                2250                2255    
Ala Gln Thr Cys Leu Val Thr Pro Ser Ser Pro Leu Leu Leu Gly Pro
            2260                2265                2270        
Pro Ser Val Pro Ile Ser Ala Ser Val Thr Asn Leu Pro Leu Gly Leu
        2275                2280                2285            
Arg Pro Glu Ala Glu Leu Cys Ala Gln Ala Leu Ala Ser Pro Glu Ser
    2290                2295                2300                
Leu Glu Leu Ala Ser Val Ala Ser Ser Glu Thr Ser Ser Leu Ser Leu
2305                2310                2315                2320
Val Pro Pro Lys Asp Leu Leu Pro Val Ala Val Glu Ile Leu Pro Val
                2325                2330                2335    
Ser Glu Lys Asn Leu Ser Leu Thr Pro Ser Ala Pro Ser Leu Thr Leu
            2340                2345                2350        
Glu Ala Gly Ser Ile Pro Asn Gly Gln Glu Gln Glu Ala Pro Asp Ser
        2355                2360                2365            
Ala Glu Gly Thr Thr Leu Thr Val Leu Pro Glu Gly Glu Glu Leu Pro
    2370                2375                2380                
Leu Cys Val Ser Glu Ser Asn Gly Leu Glu Leu Pro Pro Ser Ala Ala
2385                2390                2395                2400
Ser Asp Glu Pro Leu Gln Glu Pro Leu Glu Ala Asp Arg Thr Ser Glu
                2405                2410                2415    
Glu Leu Thr Glu Ala Lys Thr Pro Thr Ser Ser Pro Glu Lys Pro Gln
            2420                2425                2430        
Glu Leu Val Thr Ala Glu Val Ala Ala Pro Ser Thr Ser Ser Ser Ala
        2435                2440                2445            
Thr Ser Ser Pro Glu Gly Pro Ser Pro Ala Arg Pro Pro Arg Arg Arg
    2450                2455                2460                
Thr Ser Ala Asp Val Glu Ile Arg Gly Gln Gly Thr Gly Arg Pro Gly
2465                2470                2475                2480
Gln Pro Pro Gly Pro Lys Val Leu Arg Lys Leu Pro Gly Arg Leu Val
                2485                2490                2495    
Thr Val Val Glu Glu Lys Glu Leu Val Gln Arg Arg Arg Gln Gln Arg
            2500                2505                2510        
Gly Ala Ala Ser Thr Leu Val Pro Gly Val Ser Glu Thr Ser Ala Ser
        2515                2520                2525            
Pro Gly Ser Pro Ser Val Arg Ser Met Ser Gly Pro Glu Ser Ser Pro
    2530                2535                2540                
Pro Ile Gly Gly Pro Cys Glu Ala Ala Pro Ser Ser Ser Leu Pro Thr
2545                2550                2555                2560
Pro Pro Gln Gln Pro Phe Ile Ala Arg Arg His Ile Glu Leu Gly Val
                2565                2570                2575    
Thr Gly Gly Gly Ser Pro Glu Asn Gly Asp Gly Ala Leu Leu Ala Ile
            2580                2585                2590        
Thr Pro Pro Ala Val Lys Arg Arg Arg Gly Arg Pro Pro Lys Lys Asn
        2595                2600                2605            
Arg Ser Pro Ala Asp Ala Gly Arg Gly Val Asp Glu Ala Pro Ser Ser
    2610                2615                2620                
Thr Leu Lys Gly Lys Thr Asn Gly Ala Asp Pro Val Pro Gly Pro Glu
2625                2630                2635                2640
Thr Leu Ile Val Ala Asp Pro Val Leu Glu Pro Gln Leu Ile Pro Gly
                2645                2650                2655    
Pro Gln Pro Leu Gly Pro Gln Pro Val His Arg Pro Asn Pro Leu Leu
            2660                2665                2670        
Ser Pro Val Glu Lys Arg Arg Arg Gly Arg Pro Pro Lys Ala Arg Asp
        2675                2680                2685            
Leu Pro Ile Pro Gly Thr Ile Ser Ser Ala Gly Asp Gly Asn Ser Glu
    2690                2695                2700                
Ser Arg Thr Gln Pro Pro Pro His Pro Ser Pro Leu Thr Pro Leu Pro
2705                2710                2715                2720
Pro Leu Leu Val Cys Pro Thr Ala Thr Val Ala Asn Thr Val Thr Thr
                2725                2730                2735    
Val Thr Ile Ser Thr Ser Pro Pro Lys Arg Lys Arg Gly Arg Pro Pro
            2740                2745                2750        
Lys Asn Pro Pro Ser Pro Arg Pro Ser Gln Leu Pro Val Leu Asp Arg
        2755                2760                2765            
Asp Ser Thr Ser Val Leu Glu Ser Cys Gly Leu Gly Arg Arg Arg Gln
    2770                2775                2780                
Pro Gln Gly Gln Gly Glu Ser Glu Gly Ser Ser Ser Asp Glu Asp Gly
2785                2790                2795                2800
Ser Arg Pro Leu Thr Arg Leu Ala Arg Leu Arg Leu Glu Ala Glu Gly
                2805                2810                2815    
Met Arg Gly Arg Lys Ser Gly Gly Ser Met Val Val Ala Val Ile Gln
            2820                2825                2830        
Asp Asp Leu Asp Leu Ala Asp Ser Gly Pro Gly Gly Leu Glu Leu Thr
        2835                2840                2845            
Pro Pro Val Val Ser Leu Thr Pro Lys Leu Arg Ser Thr Arg Leu Arg
    2850                2855                2860                
Pro Gly Ser Leu Val Pro Pro Leu Glu Thr Glu Lys Leu Pro Arg Lys
2865                2870                2875                2880
Arg Ala Gly Ala Pro Val Gly Gly Ser Pro Gly Leu Ala Lys Arg Gly
                2885                2890                2895    
Arg Leu Gln Pro Pro Ser Pro Leu Gly Pro Glu Gly Ser Val Glu Glu
            2900                2905                2910        
Ser Glu Ala Glu Ala Ser Gly Glu Glu Glu Glu Gly Asp Gly Thr Pro
        2915                2920                2925            
Arg Arg Arg Pro Gly Pro Arg Arg Leu Val Gly Thr Thr Asn Gln Gly
    2930                2935                2940                
Asp Gln Arg Ile Leu Arg Ser Ser Ala Pro Pro Ser Leu Ala Gly Pro
2945                2950                2955                2960
Ala Val Ser His Arg Gly Arg Lys Ala Lys Thr
                2965                2970    


<210> 7675
<211> 1885
<212> PRT
<213> Homo sapiens

<400> 7675
Cys Arg Tyr Cys Arg Cys Arg Glu Asn Ala Glu Pro Ser Arg Ala Gly
 1               5                  10                  15      
Trp Ala Ala Ala Ala Arg Ala Ala Thr Gly Thr Arg Phe Pro Ser Ala
            20                  25                  30          
Ala Ala Ala Ala Met Ala Arg Leu Ala Asp Tyr Phe Ile Val Val Gly
        35                  40                  45              
Tyr Asp His Glu Lys Pro Gly Ser Gly Glu Gly Leu Gly Lys Ile Ile
    50                  55                  60                  
Gln Arg Phe Pro Gln Lys Asp Trp Asp Asp Thr Pro Phe Pro Gln Gly
65                  70                  75                  80  
Ile Glu Leu Phe Cys Gln Pro Gly Gly Trp Gln Leu Ser Arg Glu Arg
                85                  90                  95      
Lys Gln Pro Thr Phe Phe Val Val Val Leu Thr Asp Ile Asp Ser Asp
            100                 105                 110         
Arg His Tyr Cys Ser Cys Leu Thr Phe Tyr Glu Ala Glu Ile Asn Leu
        115                 120                 125             
Gln Gly Thr Lys Lys Glu Glu Ile Glu Gly Glu Ala Lys Val Ser Gly
    130                 135                 140                 
Leu Ile Gln Pro Ala Glu Val Phe Ala Pro Lys Ser Leu Val Leu Val
145                 150                 155                 160 
Ser Arg Leu Tyr Tyr Pro Glu Ile Phe Arg Ala Cys Leu Gly Leu Ile
                165                 170                 175     
Tyr Thr Val Tyr Val Asp Ser Leu Asn Val Ser Leu Glu Ser Leu Ile
            180                 185                 190         
Ala Asn Leu Cys Ala Cys Leu Val Pro Ala Ala Gly Gly Ser Gln Lys
        195                 200                 205             
Leu Phe Ser Leu Gly Ala Gly Asp Arg Gln Leu Ile Gln Thr Pro Leu
    210                 215                 220                 
His Asp Ser Leu Pro Ile Thr Gly Thr Ser Val Ala Leu Leu Phe Gln
225                 230                 235                 240 
Gln Leu Gly Ile Gln Asn Val Leu Ser Leu Phe Cys Ala Val Leu Thr
                245                 250                 255     
Glu Asn Lys Val Leu Phe His Ser Ala Ser Phe Gln Arg Leu Ser Asp
            260                 265                 270         
Ala Cys Arg Ala Leu Glu Ser Leu Met Phe Pro Leu Lys Tyr Ser Tyr
        275                 280                 285             
Pro Tyr Ile Pro Ile Leu Pro Ala Gln Leu Leu Glu Val Leu Ser Ser
    290                 295                 300                 
Pro Thr Pro Phe Ile Ile Gly Val His Ser Val Phe Lys Thr Asp Val
305                 310                 315                 320 
His Glu Leu Leu Asp Val Ile Ile Ala Asp Leu Asp Gly Gly Thr Ile
                325                 330                 335     
Lys Ile Pro Glu Cys Ile His Leu Ser Ser Leu Pro Glu Pro Leu Leu
            340                 345                 350         
His Gln Thr Gln Ser Ala Leu Ser Leu Ile Leu His Pro Asp Leu Glu
        355                 360                 365             
Val Ala Asp His Ala Phe Pro Pro Pro Arg Thr Ala Leu Ser His Ser
    370                 375                 380                 
Lys Met Leu Asp Lys Glu Val Arg Ala Val Phe Leu Arg Leu Phe Ala
385                 390                 395                 400 
Gln Leu Phe Gln Gly Tyr Arg Ser Cys Leu Gln Leu Ile Arg Ile His
                405                 410                 415     
Ala Glu Pro Val Ile His Phe His Lys Thr Ala Phe Leu Gly Gln Arg
            420                 425                 430         
Gly Leu Val Glu Asn Asp Phe Leu Thr Lys Val Leu Ser Gly Met Ala
        435                 440                 445             
Phe Ala Gly Phe Val Ser Glu Arg Gly Pro Pro Tyr Arg Ser Cys Asp
    450                 455                 460                 
Leu Phe Asp Glu Leu Val Ala Phe Glu Val Glu Arg Ile Lys Val Glu
465                 470                 475                 480 
Glu Asn Asn Pro Val Lys Met Ile Lys His Val Arg Glu Leu Ala Glu
                485                 490                 495     
Gln Leu Phe Lys Asn Glu Asn Pro Asn Pro His Met Ala Phe Gln Lys
            500                 505                 510         
Val Pro Arg Pro Thr Glu Gly Ser His Leu Arg Val His Ile Leu Pro
        515                 520                 525             
Phe Pro Glu Ile Asn Glu Ala Arg Val Gln Glu Leu Ile Gln Glu Asn
    530                 535                 540                 
Val Ala Lys Asn Gln Asn Ala Pro Pro Ala Thr Arg Ile Glu Lys Lys
545                 550                 555                 560 
Cys Val Val Pro Ala Gly Pro Pro Val Val Ser Ile Met Asp Lys Val
                565                 570                 575     
Thr Thr Val Phe Asn Ser Ala Gln Arg Leu Glu Val Val Arg Asn Cys
            580                 585                 590         
Ile Ser Phe Ile Phe Glu Asn Lys Ile Leu Glu Thr Glu Lys Thr Leu
        595                 600                 605             
Pro Ala Ala Leu Arg Ala Leu Lys Gly Lys Ala Ala Arg Gln Cys Leu
    610                 615                 620                 
Thr Asp Glu Leu Gly Leu His Val Gln Gln Asn Arg Ala Ile Leu Asp
625                 630                 635                 640 
His Gln Gln Phe Asp Tyr Ile Ile Arg Met Met Asn Cys Thr Leu Gln
                645                 650                 655     
Asp Cys Ser Ser Leu Glu Glu Tyr Asn Ile Ala Ala Ala Leu Leu Pro
            660                 665                 670         
Leu Thr Ser Ala Phe Tyr Arg Lys Leu Ala Pro Gly Val Ser Gln Phe
        675                 680                 685             
Ala Tyr Thr Cys Val Gln Asp His Pro Ile Trp Thr Asn Gln Gln Phe
    690                 695                 700                 
Trp Glu Thr Thr Phe Tyr Asn Ala Val Gln Glu Gln Val Arg Ser Leu
705                 710                 715                 720 
Tyr Leu Ser Ala Lys Glu Asp Asn His Ala Pro His Leu Lys Gln Lys
                725                 730                 735     
Asp Lys Leu Pro Asp Asp His Tyr Gln Glu Lys Thr Ala Met Asp Leu
            740                 745                 750         
Ala Ala Glu Gln Leu Arg Leu Trp Pro Thr Leu Ser Lys Ser Thr Gln
        755                 760                 765             
Gln Glu Leu Val Gln His Glu Glu Ser Thr Val Phe Ser Gln Ala Ile
    770                 775                 780                 
His Phe Ala Asn Leu Met Val Asn Leu Leu Val Pro Leu Asp Thr Ser
785                 790                 795                 800 
Lys Asn Lys Leu Leu Arg Thr Ser Ala Pro Gly Asp Trp Glu Ser Gly
                805                 810                 815     
Ser Asn Ser Ile Val Thr Asn Ser Ile Ala Gly Ser Val Ala Glu Ser
            820                 825                 830         
Tyr Asp Thr Glu Ser Gly Phe Glu Asp Ser Glu Asn Thr Asp Ile Ala
        835                 840                 845             
Asn Ser Val Val Arg Phe Ile Thr Arg Phe Ile Asp Lys Val Cys Thr
    850                 855                 860                 
Glu Ser Gly Val Thr Gln Asp His Ile Lys Ser Leu His Cys Met Ile
865                 870                 875                 880 
Pro Gly Ile Val Ala Met His Ile Glu Thr Leu Glu Ala Val His Arg
                885                 890                 895     
Glu Ser Arg Arg Leu Pro Pro Ile Gln Lys Pro Lys Ile Leu Arg Pro
            900                 905                 910         
Ala Leu Leu Pro Gly Glu Glu Ile Val Cys Glu Gly Leu Arg Val Leu
        915                 920                 925             
Leu Asp Pro Asp Gly Arg Glu Glu Ala Thr Gly Gly Leu Leu Gly Gly
    930                 935                 940                 
Pro Gln Leu Leu Pro Ala Glu Gly Ala Leu Phe Leu Thr Thr Tyr Arg
945                 950                 955                 960 
Ile Leu Phe Arg Gly Thr Pro His Asp Gln Leu Val Gly Glu Gln Thr
                965                 970                 975     
Val Val Arg Ser Phe Pro Ile Ala Ser Ile Thr Lys Glu Lys Lys Ile
            980                 985                 990         
Thr Met Gln Asn Gln Leu Gln Gln Asn Met Gln Glu Gly Leu Gln Ile
        995                 1000                1005            
Thr Ser Ala Ser Phe Gln Leu Ile Lys Val Ala Phe Asp Glu Glu Val
    1010                1015                1020                
Ser Pro Glu Val Val Glu Ile Phe Lys Lys Gln Leu Met Lys Phe Arg
1025                1030                1035                1040
Tyr Pro Gln Ser Ile Phe Ser Thr Phe Ala Phe Ala Ala Gly Gln Thr
                1045                1050                1055    
Thr Pro Gln Ile Ile Leu Pro Lys Gln Lys Glu Lys Asn Thr Ser Phe
            1060                1065                1070        
Arg Thr Phe Ser Lys Thr Ile Val Lys Gly Ala Lys Arg Ala Gly Lys
        1075                1080                1085            
Met Thr Ile Gly Arg Gln Tyr Leu Leu Lys Lys Lys Thr Gly Thr Ile
    1090                1095                1100                
Val Glu Glu Arg Val Asn Arg Pro Gly Trp Asn Glu Asp Asp Asp Val
1105                1110                1115                1120
Ser Val Ser Asp Glu Ser Glu Leu Pro Thr Ser Thr Thr Leu Lys Ala
                1125                1130                1135    
Ser Glu Lys Ser Thr Met Glu Gln Leu Val Glu Lys Ala Cys Phe Arg
            1140                1145                1150        
Asp Tyr Gln Arg Leu Gly Leu Gly Thr Ile Ser Gly Ser Ser Ser Arg
        1155                1160                1165            
Ser Arg Pro Glu Tyr Phe Arg Ile Thr Ala Ser Asn Arg Met Tyr Ser
    1170                1175                1180                
Leu Cys Arg Ser Tyr Pro Gly Leu Leu Val Val Pro Gln Ala Val Gln
1185                1190                1195                1200
Asp Ser Ser Leu Pro Arg Val Ala Arg Cys Tyr Arg His Asn Arg Leu
                1205                1210                1215    
Pro Val Val Cys Trp Lys Asn Ser Arg Ser Gly Thr Leu Leu Leu Arg
            1220                1225                1230        
Ser Gly Gly Phe His Gly Lys Gly Val Val Gly Leu Phe Lys Ser Gln
        1235                1240                1245            
Asn Ser Pro Gln Ala Ala Pro Thr Ser Ser Leu Glu Ser Ser Ser Ser
    1250                1255                1260                
Ile Glu Gln Glu Lys Tyr Leu Gln Ala Leu Leu Asn Ala Val Ser Val
1265                1270                1275                1280
His Gln Lys Leu Arg Gly Asn Ser Thr Leu Thr Val Arg Pro Ala Phe
                1285                1290                1295    
Ala Leu Ser Pro Gly Val Trp Ala Ser Leu Arg Ser Ser Thr Arg Leu
            1300                1305                1310        
Ile Ser Ser Pro Thr Ser Phe Ile Asp Val Gly Ala Arg Leu Ala Gly
        1315                1320                1325            
Lys Asp His Ser Ala Ser Phe Ser Asn Ser Ser Tyr Leu Gln Asn Gln
    1330                1335                1340                
Leu Leu Lys Arg Gln Ala Ala Leu Tyr Ile Phe Gly Glu Lys Ser Gln
1345                1350                1355                1360
Leu Arg Asn Phe Lys Val Glu Phe Ala Leu Asn Cys Glu Phe Val Pro
                1365                1370                1375    
Val Glu Phe His Glu Ile Arg Gln Val Lys Ala Ser Phe Lys Lys Leu
            1380                1385                1390        
Met Arg Ala Cys Ile Pro Ser Thr Ile Pro Thr Asp Ser Glu Val Thr
        1395                1400                1405            
Phe Leu Lys Ala Leu Gly Asp Ser Glu Trp Phe Pro Gln Leu His Arg
    1410                1415                1420                
Ile Met Gln Leu Ala Val Val Val Ser Glu Val Leu Glu Asn Gly Ser
1425                1430                1435                1440
Ser Val Leu Val Cys Leu Glu Glu Gly Trp Asp Ile Thr Ala Gln Val
                1445                1450                1455    
Thr Ser Leu Val Gln Leu Leu Ser Asp Pro Phe Tyr Arg Thr Leu Glu
            1460                1465                1470        
Gly Phe Gln Met Leu Val Glu Lys Glu Trp Leu Ser Phe Gly His Lys
        1475                1480                1485            
Phe Ser Gln Arg Ser Ser Leu Thr Leu Asn Cys Gln Gly Ser Gly Phe
    1490                1495                1500                
Ala Pro Val Phe Leu Gln Phe Leu Asp Cys Val His Gln Val His Asn
1505                1510                1515                1520
Gln Tyr Pro Thr Glu Phe Glu Phe Asn Leu Tyr Tyr Leu Lys Phe Leu
                1525                1530                1535    
Ala Phe His Tyr Val Ser Asn Arg Phe Lys Thr Phe Leu Leu Asp Ser
            1540                1545                1550        
Asp Tyr Glu Arg Leu Glu His Gly Thr Leu Phe Asp Asp Lys Gly Glu
        1555                1560                1565            
Lys His Ala Lys Lys Gly Val Cys Ile Trp Glu Cys Ile Asp Arg Met
    1570                1575                1580                
His Lys Arg Ser Pro Ile Phe Phe Asn Tyr Leu Tyr Ser Pro Leu Glu
1585                1590                1595                1600
Ile Glu Ala Leu Lys Pro Asn Val Asn Val Ser Ser Leu Lys Lys Trp
                1605                1610                1615    
Asp Tyr Tyr Ile Glu Glu Thr Leu Ser Thr Gly Pro Ser Tyr Asp Trp
            1620                1625                1630        
Met Met Leu Thr Pro Lys His Phe Pro Ser Glu Asp Ser Asp Leu Ala
        1635                1640                1645            
Gly Glu Ala Gly Pro Arg Ser Gln Arg Arg Thr Val Trp Pro Cys Tyr
    1650                1655                1660                
Asp Asp Val Ser Cys Thr Gln Pro Asp Ala Leu Thr Ser Leu Phe Ser
1665                1670                1675                1680
Glu Ile Glu Lys Leu Glu His Lys Leu Asn Gln Ala Pro Glu Lys Trp
                1685                1690                1695    
Gln Gln Leu Trp Glu Arg Val Thr Val Asp Leu Lys Glu Glu Pro Arg
            1700                1705                1710        
Thr Asp Arg Ser Gln Arg His Leu Ser Arg Ser Pro Gly Ile Val Ser
        1715                1720                1725            
Thr Asn Leu Pro Ser Tyr Gln Lys Arg Ser Leu Leu His Leu Pro Asp
    1730                1735                1740                
Ser Ser Met Gly Glu Glu Gln Asn Ser Ser Ile Ser Pro Ser Asn Gly
1745                1750                1755                1760
Val Glu Arg Arg Ala Ala Thr Leu Tyr Ser Gln Tyr Thr Ser Lys Asn
                1765                1770                1775    
Asp Glu Asn Arg Ser Phe Glu Gly Thr Leu Tyr Lys Arg Gly Ala Leu
            1780                1785                1790        
Leu Lys Gly Trp Lys Pro Arg Trp Phe Val Leu Asp Val Thr Lys His
        1795                1800                1805            
Gln Leu Arg Tyr Tyr Asp Ser Gly Glu Asp Thr Ser Cys Lys Gly His
    1810                1815                1820                
Ile Asp Leu Ala Glu Val Glu Met Val Ile Pro Ala Gly Pro Ser Met
1825                1830                1835                1840
Gly Ala Pro Lys His Thr Ser Asp Lys Ala Phe Phe Asp Leu Lys Thr
                1845                1850                1855    
Ser Lys Arg Val Tyr Asn Phe Cys Ala Gln Asp Gly Gln Ser Ala Gln
            1860                1865                1870        
Gln Trp Met Asp Lys Ile Gln Ser Cys Ile Ser Asp Ala
        1875                1880                1885


<210> 7676
<211> 1302
<212> PRT
<213> Homo sapiens

<400> 7676
Met Glu Leu Tyr Phe Gly Glu Tyr Gln His Val Gln Gln Glu Tyr Gly
 1               5                  10                  15      
Val His Leu Arg Leu Ala Ser Asp Asp Thr Gln Lys Ser Arg Ser Ser
            20                  25                  30          
Gln Asn Ser Lys Ala Gly Ser Tyr Gly Val Ser Ile Arg Val Gln Gly
        35                  40                  45              
Ile Asp Gly His Pro Tyr Ile Val Leu Asn Asn Thr Glu Arg Cys Leu
    50                  55                  60                  
Ala Gly Thr Ser Phe Ser Glu Asn Gly Pro Pro Phe Pro Pro Pro Val
65                  70                  75                  80  
Ile Asn Asn Leu Pro Leu His Ser Ser Asn Gly Ser Val Pro Lys Glu
                85                  90                  95      
Asn Ser Glu Glu Leu Gln Leu Pro Glu Asn Pro Tyr Ala Gln Pro Ser
            100                 105                 110         
Pro Ile Arg Asn Leu Lys Gln Pro Leu Leu His Glu Gly Lys Asn Gly
        115                 120                 125             
Val Leu Asp Arg Lys Asp Gly Ser Val Lys Pro Ser His Leu Leu Asn
    130                 135                 140                 
Phe Gln Arg His Pro Glu Leu Leu Gln Pro Tyr Asp Pro Glu Lys Asn
145                 150                 155                 160 
Glu Leu Asn Leu Gln Asn His Gln Pro Ser Glu Ser Asn Trp Leu Lys
                165                 170                 175     
Thr Leu Thr Glu Glu Gly Ile Asn Asn Lys Lys Pro Trp Thr Cys Phe
            180                 185                 190         
Pro Lys Pro Ser Asn Ser Gln Pro Thr Ser Pro Ser Leu Glu Asp Pro
        195                 200                 205             
Ala Lys Ser Gly Val Thr Ala Ile Arg Leu Cys Ser Ser Val Val Ile
    210                 215                 220                 
Glu Asp Pro Lys Lys Gln Thr Ser Val Cys Val Asn Val Gln Ser Cys
225                 230                 235                 240 
Thr Lys Glu Arg Val Gly Glu Glu Ala Leu Phe Thr Ser Gly Arg Pro
                245                 250                 255     
Leu Thr Ala His Ser Pro His Ala His Pro Glu Thr Lys Lys Thr Arg
            260                 265                 270         
Pro Asp Val Leu Pro Phe Arg Arg Gln Asp Ser Ala Gly Pro Val Leu
        275                 280                 285             
Asp Gly Ala Arg Ser Arg Arg Ser Ser Ser Ser Ser Thr Thr Pro Thr
    290                 295                 300                 
Ser Ala Asn Ser Leu Tyr Arg Phe Leu Leu Asp Asp Gln Glu Cys Ala
305                 310                 315                 320 
Ile His Ala Asp Asn Val Asn Arg His Glu Asn Arg Arg Tyr Ile Pro
                325                 330                 335     
Phe Leu Pro Gly Thr Gly Arg Asp Ile Asp Thr Gly Ser Ile Pro Gly
            340                 345                 350         
Val Asp Gln Leu Ile Glu Lys Phe Asp Gln Lys Pro Gly Leu Gln Arg
        355                 360                 365             
Arg Gly Arg Ser Gly Lys Arg Asn Arg Ile Asn Thr Asp Asp Arg Lys
    370                 375                 380                 
Arg Ser Arg Ser Val Asp Ser Ala Phe Pro Phe Gly Leu Gln Gly Asn
385                 390                 395                 400 
Ser Glu Tyr Leu Ile Glu Phe Ser Arg Asn Leu Gly Lys Ser Ser Glu
                405                 410                 415     
His Leu Leu Arg Pro Ser Gln Val Cys Pro Gln Arg Pro Leu Ser Gln
            420                 425                 430         
Glu Arg Arg Gly Lys Gln Ser Val Gly Arg Thr Phe Ala Lys Leu Gln
        435                 440                 445             
Gly Ala Ala His Gly Ala Ser Cys Ala His Ser Arg Pro Pro Gln Pro
    450                 455                 460                 
Asn Ile Asp Gly Lys Val Leu Glu Thr Glu Gly Ser Gln Glu Ser Thr
465                 470                 475                 480 
Val Ile Arg Ala Pro Ser Leu Gly Ala Gln Ser Lys Lys Glu Glu Glu
                485                 490                 495     
Val Lys Thr Ala Thr Ala Thr Leu Met Leu Gln Asn Arg Ala Thr Ala
            500                 505                 510         
Thr Ser Pro Asp Ser Gly Ala Lys Lys Ile Ser Val Lys Thr Phe Pro
        515                 520                 525             
Ser Ala Ser Asn Thr Gln Ala Thr Pro Asp Leu Leu Lys Gly Gln Gln
    530                 535                 540                 
Glu Leu Thr Gln Gln Thr Asn Glu Glu Thr Ala Lys Gln Ile Leu Tyr
545                 550                 555                 560 
Asn Tyr Leu Lys Glu Gly Ser Thr Asp Asn Asp Asp Ala Thr Lys Arg
                565                 570                 575     
Lys Val Asn Leu Val Phe Glu Lys Ile Gln Thr Leu Lys Ser Arg Ala
            580                 585                 590         
Ala Gly Ser Ala Gln Gly Asn Asn Gln Ala Cys Asn Ser Thr Ser Glu
        595                 600                 605             
Val Lys Asp Leu Leu Glu Gln Lys Ser Lys Leu Thr Ile Glu Val Ala
    610                 615                 620                 
Glu Leu Gln Arg Gln Leu Gln Leu Glu Val Lys Asn Gln Gln Asn Ile
625                 630                 635                 640 
Lys Glu Glu Arg Glu Arg Met Arg Ala Asn Leu Glu Glu Leu Arg Ser
                645                 650                 655     
Gln His Asn Glu Lys Val Glu Glu Asn Ser Thr Leu Gln Gln Arg Leu
            660                 665                 670         
Glu Glu Ser Glu Gly Glu Leu Arg Lys Asn Leu Glu Glu Leu Phe Gln
        675                 680                 685             
Val Lys Met Glu Arg Glu Gln His Gln Thr Glu Ile Arg Asp Leu Gln
    690                 695                 700                 
Asp Gln Leu Ser Glu Met His Asp Glu Leu Asp Ser Ala Lys Arg Ser
705                 710                 715                 720 
Glu Asp Arg Glu Lys Gly Ala Leu Ile Glu Glu Leu Leu Gln Ala Lys
                725                 730                 735     
Gln Asp Leu Gln Asp Leu Leu Ile Ala Lys Glu Glu Gln Glu Asp Leu
            740                 745                 750         
Leu Arg Lys Arg Glu Arg Glu Leu Thr Ala Leu Lys Gly Ala Leu Lys
        755                 760                 765             
Glu Glu Val Ser Ser His Asp Gln Glu Met Asp Lys Leu Lys Glu Gln
    770                 775                 780                 
Tyr Asp Ala Glu Leu Gln Ala Leu Arg Glu Ser Val Glu Glu Ala Thr
785                 790                 795                 800 
Lys Asn Val Glu Val Leu Ala Ser Arg Ser Asn Thr Ser Glu Gln Asp
                805                 810                 815     
Gln Ala Gly Thr Glu Met Arg Val Lys Leu Leu Gln Glu Glu Asn Glu
            820                 825                 830         
Lys Leu Gln Gly Arg Ser Glu Glu Leu Glu Arg Arg Val Ala Gln Leu
        835                 840                 845             
Gln Arg Gln Ile Glu Asp Leu Lys Gly Asp Glu Ala Lys Ala Lys Glu
    850                 855                 860                 
Thr Leu Lys Lys Tyr Glu Gly Glu Ile Arg Gln Leu Glu Glu Ala Leu
865                 870                 875                 880 
Val His Ala Arg Lys Glu Glu Lys Glu Ala Val Ser Ala Arg Arg Ala
                885                 890                 895     
Leu Glu Asn Glu Leu Glu Ala Ala Gln Gly Asn Leu Ser Gln Thr Thr
            900                 905                 910         
Gln Glu Gln Lys Gln Leu Ser Glu Lys Leu Lys Glu Glu Ser Glu Gln
        915                 920                 925             
Lys Glu Gln Leu Arg Arg Leu Lys Asn Glu Met Glu Asn Glu Arg Trp
    930                 935                 940                 
His Leu Gly Lys Thr Ile Glu Lys Leu Gln Lys Glu Met Ala Asp Ile
945                 950                 955                 960 
Val Glu Ala Ser Arg Thr Ser Thr Leu Glu Leu Gln Asn Gln Leu Asp
                965                 970                 975     
Glu Tyr Lys Glu Lys Asn Arg Arg Glu Leu Ala Glu Met Gln Arg Gln
            980                 985                 990         
Leu Lys Glu Lys Thr Leu Glu Ala Glu Lys Ser Arg Leu Thr Ala Met
        995                 1000                1005            
Lys Met Gln Asp Glu Met Arg Leu Met Glu Glu Glu Leu Arg Asp Tyr
    1010                1015                1020                
Gln Arg Ala Gln Asp Glu Ala Leu Thr Lys Arg Gln Leu Leu Glu Gln
1025                1030                1035                1040
Thr Leu Lys Asp Leu Glu Tyr Glu Leu Glu Ala Lys Ser His Leu Lys
                1045                1050                1055    
Asp Asp Arg Ser Arg Leu Val Lys Gln Met Glu Asp Lys Val Ser Gln
            1060                1065                1070        
Leu Glu Met Glu Leu Glu Glu Glu Arg Asn Asn Ser Asp Leu Leu Ser
        1075                1080                1085            
Glu Arg Ile Ser Arg Ser Arg Glu Gln Met Glu Gln Leu Arg Asn Glu
    1090                1095                1100                
Leu Leu Gln Glu Arg Ala Ala Arg Gln Asp Leu Glu Cys Asp Lys Ile
1105                1110                1115                1120
Ser Leu Glu Arg Gln Asn Lys Asp Leu Lys Ser Arg Ile Ile His Leu
                1125                1130                1135    
Glu Gly Ser Tyr Arg Ser Ser Lys Glu Gly Leu Val Val Gln Met Glu
            1140                1145                1150        
Ala Arg Ile Ala Glu Leu Glu Asp Arg Leu Glu Ser Glu Glu Arg Asp
        1155                1160                1165            
Arg Ala Asn Leu Gln Leu Ser Asn Arg Arg Leu Glu Arg Lys Val Lys
    1170                1175                1180                
Glu Leu Val Met Gln Val Asp Asp Glu His Leu Ser Leu Thr Asp Gln
1185                1190                1195                1200
Lys Asp Gln Leu Ser Leu Arg Leu Lys Ala Met Lys Arg Gln Val Glu
                1205                1210                1215    
Glu Ala Glu Glu Glu Ile Asp Arg Leu Glu Ser Ser Lys Lys Lys Leu
            1220                1225                1230        
Gln Arg Glu Leu Glu Glu Gln Met Asp Met Asn Glu His Leu Gln Gly
        1235                1240                1245            
Gln Leu Asn Ser Met Lys Lys Asp Leu Arg Leu Lys Lys Leu Pro Ser
    1250                1255                1260                
Lys Val Leu Asp Asp Met Asp Asp Asp Asp Asp Leu Ser Thr Asp Gly
1265                1270                1275                1280
Gly Ser Leu Tyr Glu Ala Pro Val Ser Tyr Thr Phe Ser Lys Asp Ser
                1285                1290                1295    
Thr Val Ala Ser Gln Ile
            1300        


<210> 7677
<211> 2186
<212> PRT
<213> Homo sapiens

<400> 7677
Met Ala Gly Glu Arg Thr Arg Arg Phe Thr Arg Ser Leu Leu Arg Pro
 1               5                  10                  15      
Gly Gln Ala Ala Glu Leu Arg His Ser Ala Ala Ser Ala Ala Ala Val
            20                  25                  30          
Ala Val Ser Ser Arg Gln Gln Gln Arg Gln Glu Lys Pro Arg Leu Leu
        35                  40                  45              
Glu Pro Leu Asp Tyr Glu Thr Val Ile Glu Glu Leu Glu Lys Thr Tyr
    50                  55                  60                  
Arg Asn Asp Pro Leu Gln Asp Leu Leu Phe Phe Pro Ser Asp Asp Phe
65                  70                  75                  80  
Ser Ala Ala Thr Val Ser Trp Asp Ile Arg Thr Leu Tyr Ser Thr Val
                85                  90                  95      
Pro Glu Asp Ala Glu His Lys Ala Glu Asn Leu Leu Val Lys Glu Ala
            100                 105                 110         
Cys Lys Phe Tyr Ser Ser Gln Trp His Val Val Asn Tyr Lys Tyr Glu
        115                 120                 125             
Gln Tyr Ser Gly Asp Ile Arg Gln Leu Pro Arg Ala Glu Tyr Lys Pro
    130                 135                 140                 
Glu Lys Leu Pro Ser His Ser Phe Glu Ile Asp His Glu Asp Ala Asp
145                 150                 155                 160 
Lys Asp Glu Asp Thr Thr Ser His Ser Ser Ser Lys Gly Gly Gly Gly
                165                 170                 175     
Ala Gly Gly Thr Gly Val Phe Lys Ser Gly Trp Leu Tyr Lys Gly Asn
            180                 185                 190         
Phe Asn Ser Thr Val Asn Asn Thr Val Thr Val Arg Ser Phe Lys Lys
        195                 200                 205             
Arg Tyr Phe Gln Leu Thr Gln Leu Pro Asp Asn Ser Tyr Ile Met Asn
    210                 215                 220                 
Phe Tyr Lys Asp Glu Lys Ile Ser Lys Glu Pro Lys Gly Cys Ile Phe
225                 230                 235                 240 
Leu Asp Ser Cys Thr Gly Val Val Gln Asn Asn Arg Leu Arg Lys Tyr
                245                 250                 255     
Ala Phe Glu Leu Lys Met Asn Asp Leu Thr Tyr Phe Val Leu Ala Ala
            260                 265                 270         
Glu Thr Glu Ser Asp Met Asp Glu Trp Ile His Thr Leu Asn Arg Ile
        275                 280                 285             
Leu Gln Ile Ser Pro Glu Gly Pro Leu Gln Gly Arg Arg Ser Thr Glu
    290                 295                 300                 
Leu Thr Asp Leu Gly Leu Asp Ser Leu Asp Asn Ser Val Thr Cys Glu
305                 310                 315                 320 
Cys Thr Pro Glu Glu Thr Asp Ser Ser Glu Asn Asn Leu His Ala Asp
                325                 330                 335     
Phe Ala Lys Tyr Leu Thr Glu Thr Glu Asp Thr Val Lys Thr Thr Arg
            340                 345                 350         
Asn Met Glu Arg Leu Asn Leu Phe Ser Leu Asp Pro Asp Ile Asp Thr
        355                 360                 365             
Leu Lys Leu Gln Lys Lys Asp Leu Leu Glu Pro Glu Ser Val Ile Lys
    370                 375                 380                 
Pro Phe Glu Glu Lys Ala Ala Lys Arg Ile Met Ile Ile Cys Lys Ala
385                 390                 395                 400 
Leu Asn Ser Asn Leu Gln Gly Cys Val Thr Glu Asn Glu Asn Asp Pro
                405                 410                 415     
Ile Thr Asn Ile Glu Pro Phe Phe Val Ser Val Ala Leu Tyr Asp Leu
            420                 425                 430         
Arg Asp Ser Arg Lys Ile Ser Ala Asp Phe His Val Asp Leu Asn His
        435                 440                 445             
Ala Ala Val Arg Gln Met Leu Leu Gly Ala Ser Val Ala Leu Glu Asn
    450                 455                 460                 
Gly Asn Ile Asp Thr Ile Thr Pro Arg Gln Ser Glu Glu Pro His Ile
465                 470                 475                 480 
Lys Gly Leu Pro Glu Glu Trp Leu Lys Phe Pro Lys Gln Ala Val Phe
                485                 490                 495     
Ser Val Ser Asn Pro His Ser Glu Ile Val Leu Val Ala Lys Ile Glu
            500                 505                 510         
Lys Val Leu Met Gly Asn Ile Ala Ser Gly Ala Glu Pro Tyr Ile Lys
        515                 520                 525             
Asn Pro Asp Ser Asn Lys Tyr Ala Gln Lys Ile Leu Lys Ser Asn Arg
    530                 535                 540                 
Gln Phe Cys Ser Lys Leu Gly Lys Tyr Arg Met Pro Phe Ala Trp Ala
545                 550                 555                 560 
Val Arg Ser Val Phe Lys Asp Asn Gln Gly Asn Val Asp Arg Asp Ser
                565                 570                 575     
Arg Phe Ser Pro Leu Phe Arg Gln Glu Ser Ser Lys Ile Ser Thr Glu
            580                 585                 590         
Asp Leu Val Lys Leu Val Ser Asp Tyr Arg Arg Ala Asp Arg Ile Ser
        595                 600                 605             
Lys Met Gln Thr Ile Pro Gly Ser Leu Asp Ile Ala Val Asp Asn Val
    610                 615                 620                 
Pro Leu Glu His Pro Asn Cys Val Thr Ser Ser Phe Ile Pro Val Lys
625                 630                 635                 640 
Pro Phe Asn Met Met Ala Gln Thr Glu Pro Thr Val Glu Val Glu Glu
                645                 650                 655     
Phe Val Tyr Asp Ser Thr Lys Tyr Cys Arg Pro Tyr Arg Val Tyr Lys
            660                 665                 670         
Asn Gln Ile Tyr Ile Tyr Pro Lys His Leu Lys Tyr Asp Ser Gln Lys
        675                 680                 685             
Cys Phe Asn Lys Ala Arg Asn Ile Thr Val Cys Ile Glu Phe Lys Asn
    690                 695                 700                 
Ser Asp Glu Glu Ser Ala Lys Pro Leu Lys Cys Ile Tyr Gly Lys Pro
705                 710                 715                 720 
Gly Gly Pro Leu Phe Thr Ser Ala Ala Tyr Thr Ala Val Leu His His
                725                 730                 735     
Ser Gln Asn Pro Asp Phe Ser Asp Glu Val Lys Ile Glu Leu Pro Thr
            740                 745                 750         
Gln Leu His Glu Lys His His Ile Leu Phe Ser Phe Tyr His Val Thr
        755                 760                 765             
Cys Asp Ile Asn Ala Lys Ala Asn Ala Lys Lys Lys Glu Ala Leu Glu
    770                 775                 780                 
Thr Ser Val Gly Tyr Ala Trp Leu Pro Leu Met Lys His Asp Gln Ile
785                 790                 795                 800 
Ala Ser Gln Glu Tyr Asn Ile Pro Ile Ala Thr Ser Leu Pro Pro Asn
                805                 810                 815     
Tyr Leu Ser Phe Gln Asp Ser Ala Ser Gly Lys His Gly Gly Ser Asp
            820                 825                 830         
Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Phe Lys Val Ser Thr Phe
        835                 840                 845             
Val Val Ser Thr Val Asn Thr Gln Asp Pro His Val Asn Ala Phe Phe
    850                 855                 860                 
Gln Glu Cys Gln Lys Arg Glu Lys Asp Met Ser Gln Ser Pro Thr Ser
865                 870                 875                 880 
Asn Phe Ile Arg Ser Cys Lys Asn Leu Leu Asn Val Glu Lys Ile His
                885                 890                 895     
Ala Ile Met Ser Phe Leu Pro Ile Ile Leu Asn Gln Leu Phe Lys Val
            900                 905                 910         
Leu Val Gln Asn Glu Glu Asp Glu Ile Thr Thr Thr Val Thr Arg Val
        915                 920                 925             
Leu Thr Asp Ile Val Ala Lys Cys His Glu Glu Gln Leu Asp His Ser
    930                 935                 940                 
Val Gln Ser Tyr Ile Lys Phe Val Phe Lys Thr Arg Ala Cys Lys Glu
945                 950                 955                 960 
Arg Thr Val His Glu Glu Leu Ala Lys Asn Val Thr Gly Leu Leu Lys
                965                 970                 975     
Ser Asn Asp Ser Thr Thr Val Lys His Val Leu Lys His Ser Trp Phe
            980                 985                 990         
Phe Phe Ala Ile Ile Leu Lys Ser Met Ala Gln His Leu Ile Asp Thr
        995                 1000                1005            
Asn Lys Ile Gln Leu Pro Arg Pro Gln Arg Phe Pro Glu Ser Tyr Gln
    1010                1015                1020                
Asn Glu Leu Asp Asn Leu Val Met Val Leu Ser Asp His Val Ile Trp
1025                1030                1035                1040
Lys Tyr Lys Asp Ala Leu Glu Glu Thr Arg Arg Ala Asn His Ser Val
                1045                1050                1055    
Ala Arg Phe Leu Lys Arg Cys Phe Thr Phe Met Asp Arg Gly Tyr Val
            1060                1065                1070        
Phe Lys Met Val Asn Asn Tyr Ile Ser Met Phe Ser Ser Gly Asp Leu
        1075                1080                1085            
Lys Thr Leu Cys Gln Tyr Lys Phe Asp Phe Leu Gln Glu Val Cys Gln
    1090                1095                1100                
His Glu His Phe Ile Pro Leu Cys Leu Pro Ile Arg Ser Ala Asn Ile
1105                1110                1115                1120
Pro Asp Pro Leu Thr Pro Ser Glu Ser Thr Gln Glu Leu His Ala Ser
                1125                1130                1135    
Asp Met Pro Glu Tyr Ser Val Thr Asn Glu Phe Cys Arg Lys His Phe
            1140                1145                1150        
Leu Ile Gly Ile Leu Leu Arg Glu Val Gly Phe Ala Leu Gln Glu Asp
        1155                1160                1165            
Gln Asp Val Arg His Leu Ala Leu Ala Val Leu Lys Asn Leu Met Ala
    1170                1175                1180                
Lys His Ser Phe Asp Asp Arg Tyr Arg Glu Pro Arg Lys Gln Ala Gln
1185                1190                1195                1200
Ile Ala Ser Leu Tyr Met Pro Leu Tyr Gly Met Leu Leu Asp Asn Met
                1205                1210                1215    
Pro Arg Ile Tyr Leu Lys Asp Leu Tyr Pro Phe Thr Val Asn Thr Ser
            1220                1225                1230        
Asn Gln Gly Ser Arg Asp Asp Leu Ser Thr Asn Gly Gly Phe Gln Ser
        1235                1240                1245            
Gln Thr Ala Ile Lys His Ala Asn Ser Val Asp Thr Ser Phe Ser Lys
    1250                1255                1260                
Asp Val Leu Asn Ser Ile Ala Ala Phe Ser Ser Ile Ala Ile Ser Thr
1265                1270                1275                1280
Val Asn His Ala Asp Ser Arg Ala Ser Leu Ala Ser Leu Asp Ser Asn
                1285                1290                1295    
Pro Ser Thr Asn Glu Lys Ser Ser Glu Lys Thr Asp Asn Cys Glu Lys
            1300                1305                1310        
Ile Pro Arg Pro Leu Ser Leu Ile Gly Ser Thr Leu Arg Phe Asp Lys
        1315                1320                1325            
Leu Asp Gln Ala Glu Thr Arg Ser Leu Leu Met Cys Phe Leu His Ile
    1330                1335                1340                
Met Lys Thr Ile Ser Tyr Glu Thr Leu Ile Ala Tyr Trp Gln Arg Ala
1345                1350                1355                1360
Pro Ser Pro Glu Val Ser Asp Phe Phe Ser Ile Leu Asp Val Cys Leu
                1365                1370                1375    
Gln Asn Phe Arg Tyr Leu Gly Lys Arg Asn Ile Ile Arg Lys Ile Ala
            1380                1385                1390        
Ala Ala Phe Lys Phe Val Gln Ser Thr Gln Asn Asn Gly Thr Leu Lys
        1395                1400                1405            
Gly Ser Asn Pro Ser Cys Gln Thr Ser Gly Leu Leu Ser Gln Trp Met
    1410                1415                1420                
His Ser Thr Ser Ser His Glu Gly His Lys Gln His Arg Ser Gln Thr
1425                1430                1435                1440
Leu Pro Ile Ile Arg Gly Lys Asn Ala Leu Ser Asn Pro Lys Leu Leu
                1445                1450                1455    
Gln Met Leu Asp Asn Thr Met Thr Ser Asn Ser Asn Glu Ile Asp Ile
            1460                1465                1470        
Val His His Val Asp Thr Glu Ala Asn Ile Ala Thr Glu Val Cys Leu
        1475                1480                1485            
Thr Ile Leu Asp Leu Leu Ser Leu Phe Thr Gln Thr His Gln Arg Gln
    1490                1495                1500                
Leu Gln Gln Cys Asp Cys Gln Asn Ser Leu Met Lys Arg Val Phe Asp
1505                1510                1515                1520
Thr Tyr Met Leu Phe Phe Gln Val Asn Gln Ser Ala Thr Ala Leu Lys
                1525                1530                1535    
His Val Phe Ala Ser Leu Arg Leu Phe Val Cys Lys Phe Pro Ser Ala
            1540                1545                1550        
Phe Phe Gln Gly Pro Ala Asp Leu Cys Gly Ser Phe Cys Tyr Glu Val
        1555                1560                1565            
Leu Lys Cys Cys Asn His Arg Ser Arg Ser Thr Gln Thr Glu Ala Ser
    1570                1575                1580                
Ala Leu Leu Tyr Phe Phe Met Arg Lys Asn Phe Glu Phe Asn Lys Gln
1585                1590                1595                1600
Lys Ser Ile Val Arg Ser His Leu Gln Leu Ile Lys Ala Val Ser Gln
                1605                1610                1615    
Leu Ile Ala Asp Ala Gly Ile Gly Gly Ser Arg Phe Gln His Ser Leu
            1620                1625                1630        
Ala Ile Thr Asn Asn Phe Ala Asn Gly Asp Lys Gln Met Lys Asn Ser
        1635                1640                1645            
Asn Phe Pro Ala Glu Val Lys Asp Leu Thr Lys Arg Ile Arg Thr Val
    1650                1655                1660                
Leu Met Ala Thr Ala Gln Met Lys Glu His Glu Lys Asp Pro Glu Met
1665                1670                1675                1680
Leu Val Asp Leu Gln Tyr Ser Leu Ala Asn Ser Tyr Ala Ser Thr Pro
                1685                1690                1695    
Glu Leu Arg Arg Thr Trp Leu Glu Ser Met Ala Lys Ile His Ala Arg
            1700                1705                1710        
Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Ile His Ile Ala Ala
        1715                1720                1725            
Leu Ile Ala Glu Tyr Leu Lys Arg Lys Gly Tyr Trp Lys Val Glu Lys
    1730                1735                1740                
Ile Cys Thr Ala Ser Leu Leu Ser Glu Asp Thr His Pro Cys Asp Ser
1745                1750                1755                1760
Asn Ser Leu Leu Thr Thr Pro Ser Gly Gly Ser Met Phe Ser Met Gly
                1765                1770                1775    
Trp Pro Ala Phe Leu Ser Ile Thr Pro Asn Ile Lys Glu Glu Gly Ala
            1780                1785                1790        
Met Lys Glu Asp Ser Gly Met Gln Asp Thr Pro Tyr Asn Glu Asn Ile
        1795                1800                1805            
Leu Val Glu Gln Leu Tyr Met Cys Val Glu Phe Leu Trp Lys Ser Glu
    1810                1815                1820                
Arg Tyr Glu Leu Ile Ala Asp Val Asn Lys Pro Ile Ile Ala Val Phe
1825                1830                1835                1840
Glu Lys Gln Arg Asp Phe Lys Lys Leu Ser Asp Leu Tyr Tyr Asp Ile
                1845                1850                1855    
His Arg Ser Tyr Leu Lys Val Ala Glu Val Val Asn Ser Glu Lys Arg
            1860                1865                1870        
Leu Phe Gly Arg Tyr Tyr Arg Val Ala Phe Tyr Gly Gln Gly Phe Phe
        1875                1880                1885            
Glu Glu Glu Glu Gly Lys Glu Tyr Ile Tyr Lys Glu Pro Lys Leu Thr
    1890                1895                1900                
Gly Leu Ser Glu Ile Ser Gln Arg Leu Leu Lys Leu Tyr Ala Asp Lys
1905                1910                1915                1920
Phe Gly Ala Asp Asn Val Lys Ile Ile Gln Asp Ser Asn Lys Val Asn
                1925                1930                1935    
Pro Lys Asp Leu Asp Pro Lys Tyr Ala Tyr Ile Gln Val Thr Tyr Val
            1940                1945                1950        
Thr Pro Phe Phe Glu Glu Lys Glu Ile Glu Asp Arg Lys Thr Asp Phe
        1955                1960                1965            
Glu Met His His Asn Ile Asn Arg Phe Val Phe Glu Thr Pro Phe Thr
    1970                1975                1980                
Leu Ser Gly Lys Lys His Gly Gly Val Ala Glu Gln Cys Lys Arg Arg
1985                1990                1995                2000
Thr Ile Leu Thr Thr Ser His Leu Phe Pro Tyr Val Lys Lys Arg Ile
                2005                2010                2015    
Gln Val Ile Ser Gln Ser Ser Thr Glu Leu Asn Pro Ile Glu Val Ala
            2020                2025                2030        
Ile Asp Glu Met Ser Lys Lys Val Ser Glu Leu Asn Gln Leu Cys Thr
        2035                2040                2045            
Met Glu Glu Val Asp Met Ile Arg Leu Gln Leu Lys Leu Gln Gly Ser
    2050                2055                2060                
Val Ser Val Lys Val Asn Ala Gly Pro Met Ala Tyr Ala Arg Ala Phe
2065                2070                2075                2080
Leu Glu Glu Thr Asn Ala Lys Lys Tyr Pro Asp Asn Gln Val Lys Leu
                2085                2090                2095    
Leu Lys Glu Ile Phe Arg Gln Phe Ala Asp Ala Cys Gly Gln Ala Leu
            2100                2105                2110        
Asp Val Asn Glu Arg Leu Ile Lys Glu Asp Gln Leu Glu Tyr Gln Glu
        2115                2120                2125            
Glu Leu Arg Ser His Tyr Lys Asp Met Leu Ser Glu Leu Ser Thr Val
    2130                2135                2140                
Met Asn Glu Gln Ile Thr Gly Arg Asp Asp Leu Ser Lys Arg Gly Val
2145                2150                2155                2160
Asp Gln Thr Cys Thr Arg Val Ile Ser Lys Ala Thr Pro Ala Leu Pro
                2165                2170                2175    
Thr Val Ser Ile Ser Ser Ser Ala Glu Val
            2180                2185    


<210> 7678
<211> 476
<212> PRT
<213> Homo sapiens

<400> 7678
Met Ala Phe Gly Lys Ser His Arg Asp Pro Tyr Ala Thr Ser Val Gly
 1               5                  10                  15      
His Leu Ile Glu Lys Ala Thr Phe Ala Gly Val Gln Thr Glu Asp Trp
            20                  25                  30          
Gly Gln Phe Met His Ile Cys Asp Ile Ile Asn Thr Thr Gln Asp Ala
        35                  40                  45              
Pro Lys Asp Ala Val Lys Ala Leu Lys Lys Arg Ile Ser Lys Asn Tyr
    50                  55                  60                  
Asn His Lys Glu Ile Gln Leu Thr Leu Ser Leu Ile Asp Met Cys Val
65                  70                  75                  80  
Gln Asn Cys Gly Pro Ser Phe Gln Ser Leu Ile Val Lys Lys Glu Phe
                85                  90                  95      
Val Lys Glu Asn Leu Val Lys Leu Leu Asn Pro Arg Tyr Asn Leu Pro
            100                 105                 110         
Leu Asp Ile Gln Asn Arg Ile Leu Asn Phe Ile Lys Thr Trp Ser Gln
        115                 120                 125             
Gly Phe Pro Gly Gly Val Asp Val Ser Glu Val Lys Glu Val Tyr Leu
    130                 135                 140                 
Asp Leu Val Lys Lys Gly Val Gln Phe Pro Pro Ser Glu Ala Glu Ala
145                 150                 155                 160 
Glu Thr Ala Arg Gln Glu Thr Ala Gln Ile Ser Ser Asn Pro Pro Thr
                165                 170                 175     
Ser Val Pro Thr Ala Pro Ala Leu Ser Ser Val Ile Ala Pro Lys Asn
            180                 185                 190         
Ser Thr Val Thr Leu Val Pro Glu Gln Ile Gly Lys Leu His Ser Glu
        195                 200                 205             
Leu Asp Met Val Lys Met Asn Val Arg Val Met Ser Ala Ile Leu Met
    210                 215                 220                 
Glu Asn Thr Pro Gly Ser Glu Asn His Glu Asp Ile Glu Leu Leu Gln
225                 230                 235                 240 
Lys Leu Tyr Lys Thr Gly Arg Glu Met Gln Glu Arg Ile Met Asp Leu
                245                 250                 255     
Leu Val Val Val Glu Asn Glu Asp Val Thr Val Glu Leu Ile Gln Val
            260                 265                 270         
Asn Glu Asp Leu Asn Asn Ala Ile Leu Gly Tyr Glu Arg Phe Thr Arg
        275                 280                 285             
Asn Gln Gln Arg Ile Leu Glu Gln Asn Lys Asn Gln Lys Glu Ala Thr
    290                 295                 300                 
Asn Thr Thr Ser Glu Pro Ser Ala Pro Ser Gln Asp Leu Leu Asp Leu
305                 310                 315                 320 
Ser Pro Ser Pro Arg Met Pro Arg Ala Thr Leu Gly Glu Leu Asn Thr
                325                 330                 335     
Met Asn Asn Gln Leu Ser Gly Leu Asn Phe Ser Leu Pro Ser Ser Asp
            340                 345                 350         
Val Thr Asn Asn Leu Lys Pro Ser Leu His Pro Gln Met Asn Leu Leu
        355                 360                 365             
Ala Leu Glu Asn Thr Glu Ile Pro Pro Phe Ala Gln Arg Thr Ser Gln
    370                 375                 380                 
Asn Leu Thr Ser Ser His Ala Tyr Asp Asn Phe Leu Glu His Ser Asn
385                 390                 395                 400 
Ser Val Phe Leu Gln Pro Val Ser Leu Gln Thr Ile Ala Ala Ala Pro
                405                 410                 415     
Ser Asn Gln Ser Leu Pro Pro Leu Pro Ser Asn His Pro Ala Met Thr
            420                 425                 430         
Lys Ser Asp Leu Gln Pro Pro Asn Tyr Tyr Glu Val Met Glu Phe Asp
        435                 440                 445             
Pro Leu Ala Pro Ala Val Thr Thr Glu Ala Ile Tyr Glu Glu Ile Asp
    450                 455                 460                 
Ala His Gln His Lys Gly Ala Gln Asn Asp Gly Asp
465                 470                 475     


<210> 7679
<211> 379
<212> PRT
<213> Homo sapiens

<400> 7679
Met Ala Ala Thr Glu Gly Val Gly Glu Ala Ala Gln Gly Gly Glu Pro
 1               5                  10                  15      
Gly Gln Pro Ala Gln Pro Pro Pro Gln Pro His Pro Pro Pro Pro Gln
            20                  25                  30          
Gln Gln His Lys Glu Glu Met Ala Ala Glu Ala Gly Glu Ala Val Ala
        35                  40                  45              
Ser Pro Met Asp Asp Gly Phe Val Ser Leu Asp Ser Pro Ser Tyr Val
    50                  55                  60                  
Leu Tyr Arg Asp Arg Ala Glu Trp Ala Asp Ile Asp Pro Val Pro Gln
65                  70                  75                  80  
Asn Asp Gly Pro Asn Pro Val Val Gln Ile Ile Tyr Ser Asp Lys Phe
                85                  90                  95      
Arg Asp Val Tyr Asp Tyr Phe Arg Ala Val Leu Gln Arg Asp Glu Arg
            100                 105                 110         
Ser Glu Arg Ala Phe Lys Leu Thr Arg Asp Ala Ile Glu Leu Asn Ala
        115                 120                 125             
Ala Asn Tyr Thr Val Trp His Phe Arg Arg Val Leu Leu Lys Ser Leu
    130                 135                 140                 
Gln Lys Asp Leu His Glu Glu Met Asn Tyr Ile Thr Ala Ile Ile Glu
145                 150                 155                 160 
Glu Gln Pro Lys Asn Tyr Gln Val Trp His His Arg Arg Val Leu Val
                165                 170                 175     
Glu Trp Leu Arg Asp Pro Ser Gln Glu Leu Glu Phe Ile Ala Asp Ile
            180                 185                 190         
Leu Asn Gln Asp Ala Lys Asn Tyr His Ala Trp Gln His Arg Gln Trp
        195                 200                 205             
Val Ile Gln Glu Phe Lys Leu Trp Asp Asn Glu Leu Gln Tyr Val Asp
    210                 215                 220                 
Gln Leu Leu Lys Glu Asp Val Arg Asn Asn Ser Val Trp Asn Gln Arg
225                 230                 235                 240 
Tyr Phe Val Ile Ser Asn Thr Thr Gly Tyr Asn Asp Arg Ala Val Leu
                245                 250                 255     
Glu Arg Glu Val Gln Tyr Thr Leu Glu Met Ile Lys Leu Val Pro His
            260                 265                 270         
Asn Glu Ser Ala Trp Asn Tyr Leu Lys Gly Ile Leu Gln Asp Arg Gly
        275                 280                 285             
Leu Ser Lys Tyr Pro Asn Leu Leu Asn Gln Leu Leu Asp Leu Gln Pro
    290                 295                 300                 
Ser His Ser Ser Pro Tyr Leu Ile Ala Phe Leu Val Asp Ile Tyr Glu
305                 310                 315                 320 
Asp Met Leu Glu Asn Gln Cys Asp Asn Lys Glu Asp Ile Leu Asn Lys
                325                 330                 335     
Ala Leu Glu Leu Cys Glu Ile Leu Ala Lys Glu Lys Asp Thr Ile Arg
            340                 345                 350         
Lys Glu Tyr Trp Arg Tyr Ile Gly Arg Ser Leu Gln Ser Lys His Ser
        355                 360                 365             
Thr Glu Asn Asp Ser Pro Thr Asn Val Gln Gln
    370                 375                 


<210> 7680
<211> 214
<212> PRT
<213> Homo sapiens

<400> 7680
Met Ser Cys Thr Val Arg Asp Val Tyr Asp Tyr Phe Arg Ala Val Leu
 1               5                  10                  15      
Gln Arg Asp Glu Arg Ser Glu Arg Ala Phe Lys Leu Thr Arg Asp Ala
            20                  25                  30          
Ile Glu Leu Asn Ala Ala Asn Tyr Thr Val Trp His Phe Arg Arg Val
        35                  40                  45              
Leu Leu Lys Ser Leu Gln Lys Asp Leu His Glu Glu Met Asn Tyr Ile
    50                  55                  60                  
Thr Ala Ile Ile Glu Glu Gln Pro Lys Asn Tyr Gln Val Trp His His
65                  70                  75                  80  
Arg Arg Val Leu Val Glu Trp Leu Arg Asp Pro Ser Gln Glu Leu Glu
                85                  90                  95      
Phe Ile Ala Asp Ile Leu Asn Gln Asp Ala Lys Asn Tyr His Ala Trp
            100                 105                 110         
Gln His Arg Gln Trp Val Ile Gln Glu Phe Lys Leu Trp Asp Asn Glu
        115                 120                 125             
Leu Gln Tyr Val Asp Gln Leu Leu Lys Glu Asp Val Arg Asn Asn Ser
    130                 135                 140                 
Val Trp Asn Gln Arg Tyr Phe Val Ile Ser Asn Thr Thr Gly Tyr Asn
145                 150                 155                 160 
Asp Arg Ala Val Leu Glu Arg Glu Val Gln Leu Val Ile Ser Phe Thr
                165                 170                 175     
Cys Ser Phe Val Thr Asn Met Phe Ala Cys Leu Pro Tyr Leu Arg His
            180                 185                 190         
Trp Gly Tyr Ser Arg Ser Arg Ser Tyr Pro Met Glu Leu Lys Glu Asp
        195                 200                 205             
Arg Val Leu Ser Gly Thr
    210                 


<210> 7681
<211> 584
<212> PRT
<213> Homo sapiens

<400> 7681
Ser Arg Ser Gln Ile Gln Pro Phe Phe Gly Arg Lys Lys Pro Leu Gln
 1               5                  10                  15      
Gln Arg Trp Thr Ser Glu Ser Trp Thr Asn Gln Asn Ser Cys Pro Pro
            20                  25                  30          
Val Val Pro Arg Leu Asp Leu Gly Ser Leu Val Asp Ser Asp Asp Glu
        35                  40                  45              
Asp Asn Phe Ser Tyr Ile Pro Leu Ser Thr Ala Asn Leu Pro Asn Ser
    50                  55                  60                  
Ser Ser Thr Leu Gly Trp Val Thr Pro Cys Gln Thr Pro Tyr Thr Gln
65                  70                  75                  80  
Tyr His Leu Asn Lys Leu Asp Gln Asn Ile Ile Pro Glu Asn Leu Pro
                85                  90                  95      
Ala Pro Thr Asp Lys Cys Lys Leu Lys Tyr Gln Gln Cys Lys Thr Glu
            100                 105                 110         
Ile Lys Glu Gly Tyr Lys Gln Tyr Ser Gln Arg Asn Ala Glu Asn Thr
        115                 120                 125             
Lys Ser Asn Val Thr His Lys Gln Ser Pro Arg Asn Lys Ile Asp Glu
    130                 135                 140                 
Lys Cys Val Gln Asp Glu Glu Ala Asn Thr Asp Asp Leu Thr Thr Leu
145                 150                 155                 160 
Asp Arg Lys Ala Ile Leu Gln Gln Gly Tyr Ala Asp Asn Ser Cys Asp
                165                 170                 175     
Lys Gln Gln Arg Ala Arg Lys Leu Asp Ala Glu Ile Val Ala Ala Glu
            180                 185                 190         
Lys Lys Lys Gln Ile Val Ala Glu Gln Val Met Ile Asp His Leu Ser
        195                 200                 205             
Arg Ala Val Ile Ser Asp Pro Glu Gln Asn Leu Ala Ile Glu Gln Lys
    210                 215                 220                 
Glu Ser Asp His Ile Leu Pro Asp Ser Lys Met Thr Pro Leu Arg Phe
225                 230                 235                 240 
Arg Lys Arg Thr Leu His Glu Thr Lys Ile Arg Thr His Ser Thr Leu
                245                 250                 255     
Thr Glu Asn Val Leu Ser His Lys Leu Gln Phe Asp Gly Arg Ile Val
            260                 265                 270         
Ser Arg Asn Gly Arg Asp Ala Cys Arg Glu Leu Ile Gly Phe Phe Phe
        275                 280                 285             
Thr His Asp Gln Ser Leu Thr Ile Tyr Glu Tyr Arg Gln Phe Gly Lys
    290                 295                 300                 
Asn Arg Thr Asn Val Leu Pro Phe Ile Gln Lys Ser Ile Tyr Ser His
305                 310                 315                 320 
Gln Cys Gly Arg Arg Lys Gly Lys Gln Tyr Arg Leu Gly Asp Phe Tyr
                325                 330                 335     
Val Gly Ala Thr Leu Thr Phe Leu Ser Ser Asp His Leu Ser Leu Pro
            340                 345                 350         
Glu Ser Ile Lys Glu Asn Thr Leu Leu Lys Leu Arg Ile Thr Asn Ile
        355                 360                 365             
Asp Gln Ile Ala Leu Asp Ser Leu Lys Thr Ala Ser Met Glu Gln Glu
    370                 375                 380                 
Asp Asp Ile Ile Ile Gln Glu Thr Asn Asp Arg Leu Val Phe Lys Ala
385                 390                 395                 400 
Ile Gln Asp Val Leu Lys Glu Lys Leu His Lys Arg Gly Val Arg Ile
                405                 410                 415     
Leu Thr Gly Leu Gly Lys Tyr Phe Gln Gln Leu Asp Lys Glu Gly Asn
            420                 425                 430         
Gly Leu Leu Asp Lys Ala Asp Phe Lys Gln Ala Leu Lys Val Phe His
        435                 440                 445             
Leu Glu Val Ser Glu Lys Asp Phe Glu Ser Ala Trp Leu Ile Leu Asn
    450                 455                 460                 
Asp Asn Gly Asn Gly Lys Val Asp Tyr Gly Glu Phe Lys Arg Gly Ile
465                 470                 475                 480 
Ile Gly Glu Met Asn Glu Tyr Arg Lys Ser Tyr Val Arg Lys Ala Phe
                485                 490                 495     
Met Lys Leu Asp Phe Asn Lys Ser Gly Ser Val Pro Ile Ile Asn Ile
            500                 505                 510         
Arg Lys Cys Tyr Cys Ala Lys Lys His Ser Gln Val Ile Ser Gly His
        515                 520                 525             
Ser Thr Glu Glu Glu Ile Lys Ser Ser Phe Leu Glu Thr Leu Lys Val
    530                 535                 540                 
Ala Cys Ser Lys Ser Asp Glu Val Ser Tyr Gly Glu Phe Glu Asp Tyr
545                 550                 555                 560 
Tyr Glu Gly Leu Ser Ile Gly Ile Val Asp Asp Glu Asp Phe Val Asn
                565                 570                 575     
Ile Leu Arg Thr Pro Trp Gly Ile
            580                 


<210> 7682
<211> 564
<212> PRT
<213> Homo sapiens

<400> 7682
Met Ile Asn Thr Gly Thr Gln Met Asp Leu Glu Val Lys Gly Val Ala
 1               5                  10                  15      
Ala Thr Ser Arg Ser Gln Ile Gln Pro Phe Phe Gly Arg Lys Lys Pro
            20                  25                  30          
Leu Gln Gln Arg Trp Thr Ser Glu Ser Trp Thr Asn Gln Asn Ser Cys
        35                  40                  45              
Pro Pro Val Val Pro Arg Leu Asp Leu Gly Ser Leu Val Asp Ser Asp
    50                  55                  60                  
Asp Glu Asp Gln Asn Ile Ile Pro Glu Asn Leu Pro Ala Pro Thr Asp
65                  70                  75                  80  
Lys Cys Lys Leu Lys Tyr Gln Gln Cys Lys Thr Glu Ile Lys Glu Gly
                85                  90                  95      
Tyr Lys Gln Tyr Ser Gln Arg Asn Ala Glu Asn Thr Lys Ser Asn Val
            100                 105                 110         
Thr His Lys Gln Ser Pro Arg Asn Lys Ile Asp Glu Lys Cys Val Gln
        115                 120                 125             
Asp Glu Glu Ala Asn Thr Asp Asp Leu Thr Thr Leu Asp Arg Lys Ala
    130                 135                 140                 
Ile Leu Gln Gln Gly Tyr Ala Asp Asn Ser Cys Asp Lys Gln Gln Arg
145                 150                 155                 160 
Ala Arg Lys Leu Asp Ala Glu Ile Val Ala Ala Glu Lys Lys Lys Gln
                165                 170                 175     
Ile Val Ala Glu Gln Val Met Ile Asp His Leu Ser Arg Ala Val Ile
            180                 185                 190         
Ser Asp Pro Glu Gln Asn Leu Ala Ile Glu Gln Lys Glu Ser Asp His
        195                 200                 205             
Ile Leu Pro Asp Ser Lys Met Thr Pro Leu Arg Phe Arg Lys Arg Thr
    210                 215                 220                 
Leu His Glu Thr Lys Ile Arg Thr His Ser Thr Leu Thr Glu Asn Val
225                 230                 235                 240 
Leu Ser His Lys Leu Gln Phe Asp Gly Arg Ile Val Ser Arg Asn Gly
                245                 250                 255     
Arg Asp Ala Cys Arg Glu Leu Ile Gly Phe Phe Phe Thr His Asp Gln
            260                 265                 270         
Ser Leu Thr Ile Tyr Glu Tyr Arg Gln Phe Gly Lys Asn Arg Thr Asn
        275                 280                 285             
Val Leu Pro Phe Ile Gln Lys Ser Ile Tyr Ser His Gln Cys Gly Arg
    290                 295                 300                 
Arg Lys Gly Lys Gln Tyr Arg Leu Gly Asp Phe Tyr Val Gly Ala Thr
305                 310                 315                 320 
Leu Thr Phe Leu Ser Ser Asp His Leu Ser Leu Pro Glu Ser Ile Lys
                325                 330                 335     
Glu Asn Thr Leu Leu Lys Leu Arg Ile Thr Asn Ile Asp Gln Ile Ala
            340                 345                 350         
Leu Asp Ser Leu Lys Thr Ala Ser Met Glu Gln Glu Asp Asp Ile Ile
        355                 360                 365             
Ile Gln Glu Thr Asn Asp Arg Leu Val Phe Lys Ala Ile Gln Asp Val
    370                 375                 380                 
Leu Lys Glu Lys Leu His Lys Arg Gly Val Arg Ile Leu Thr Gly Leu
385                 390                 395                 400 
Gly Lys Tyr Phe Gln Gln Leu Asp Lys Glu Gly Asn Gly Leu Leu Asp
                405                 410                 415     
Lys Ala Asp Phe Lys Gln Ala Leu Lys Val Phe His Leu Glu Val Ser
            420                 425                 430         
Glu Lys Asp Phe Glu Ser Ala Trp Leu Ile Leu Asn Asp Asn Gly Asn
        435                 440                 445             
Gly Lys Val Asp Tyr Gly Glu Phe Lys Arg Gly Ile Ile Gly Glu Met
    450                 455                 460                 
Asn Glu Tyr Arg Lys Ser Tyr Val Arg Lys Ala Phe Met Lys Leu Asp
465                 470                 475                 480 
Phe Asn Lys Ser Gly Ser Val Pro Ile Ile Asn Ile Arg Lys Cys Tyr
                485                 490                 495     
Cys Ala Lys Lys His Ser Gln Val Ile Ser Gly His Ser Thr Glu Glu
            500                 505                 510         
Glu Ile Lys Ser Ser Phe Leu Glu Thr Leu Lys Val Ala Cys Ser Lys
        515                 520                 525             
Ser Asp Glu Val Ser Tyr Gly Glu Phe Glu Asp Tyr Tyr Glu Gly Leu
    530                 535                 540                 
Ser Ile Gly Ile Val Asp Asp Glu Asp Phe Val Asn Ile Leu Arg Thr
545                 550                 555                 560 
Pro Trp Gly Ile
                


<210> 7683
<211> 557
<212> PRT
<213> Homo sapiens

<400> 7683
Met Gly Asn Ser Phe Cys Tyr Thr Ala Val Tyr Cys Met Ile Asn Thr
 1               5                  10                  15      
Gly Thr Gln Met Asp Leu Glu Val Lys Gly Val Ala Ala Thr Ser Arg
            20                  25                  30          
Ser Gln Ile Gln Pro Phe Phe Gly Arg Lys Lys Pro Leu Gln Gln Arg
        35                  40                  45              
Trp Thr Ser Glu Ser Trp Thr Asn Gln Asn Ser Cys Pro Pro Val Val
    50                  55                  60                  
Pro Arg Leu Asp Leu Gly Ser Leu Val Asp Ser Asp Asp Glu Asp Asn
65                  70                  75                  80  
Phe Ser Tyr Ile Pro Leu Ser Thr Ala Asn Leu Pro Asn Ser Ser Ser
                85                  90                  95      
Thr Leu Gly Trp Val Thr Pro Cys Gln Thr Pro Tyr Thr Gln Tyr His
            100                 105                 110         
Leu Asn Lys Leu Asp Gln Asn Ile Ile Pro Glu Asn Leu Pro Ala Pro
        115                 120                 125             
Thr Asp Lys Cys Lys Leu Lys Tyr Gln Gln Cys Lys Thr Glu Ile Lys
    130                 135                 140                 
Glu Gly Tyr Lys Gln Tyr Ser Gln Arg Asn Ala Glu Asn Thr Lys Ser
145                 150                 155                 160 
Asn Val Thr His Lys Gln Ser Pro Arg Asn Lys Ile Asp Glu Lys Cys
                165                 170                 175     
Val Gln Asp Glu Glu Ala Asn Thr Asp Asp Leu Thr Thr Leu Asp Arg
            180                 185                 190         
Lys Ala Ile Leu Gln Gln Gly Tyr Ala Asp Asn Ser Cys Asp Lys Gln
        195                 200                 205             
Gln Arg Ala Arg Lys Leu Asp Ala Glu Ile Val Ala Ala Glu Lys Lys
    210                 215                 220                 
Lys Gln Ile Val Ala Glu Gln Val Met Ile Asp His Leu Ser Arg Ala
225                 230                 235                 240 
Val Ile Ser Asp Pro Glu Gln Asn Leu Ala Ile Glu Gln Lys Glu Ser
                245                 250                 255     
Asp His Ile Leu Pro Asp Ser Lys Met Thr Pro Leu Arg Phe Arg Lys
            260                 265                 270         
Arg Thr Leu His Glu Thr Lys Ile Arg Thr His Ser Thr Leu Thr Glu
        275                 280                 285             
Asn Val Leu Ser His Lys Leu Gln Phe Asp Gly Arg Ile Val Ser Arg
    290                 295                 300                 
Asn Gly Arg Asp Ala Cys Arg Glu Leu Ile Gly Phe Phe Phe Thr His
305                 310                 315                 320 
Asp Gln Ser Leu Thr Ile Tyr Glu Tyr Arg Gln Phe Gly Lys Asn Arg
                325                 330                 335     
Thr Asn Val Leu Pro Phe Ile Gln Lys Ser Ile Tyr Ser His Gln Cys
            340                 345                 350         
Gly Arg Arg Lys Gly Lys Gln Tyr Arg Leu Gly Asp Phe Tyr Val Gly
        355                 360                 365             
Ala Thr Leu Thr Phe Leu Ser Ser Asp His Leu Ser Leu Pro Glu Ser
    370                 375                 380                 
Ile Lys Glu Asn Thr Leu Leu Lys Leu Arg Ile Thr Asn Ile Asp Gln
385                 390                 395                 400 
Ile Ala Leu Asp Ser Leu Lys Thr Ala Ser Met Glu Gln Glu Asp Asp
                405                 410                 415     
Ile Ile Ile Gln Glu Thr Asn Asp Arg Leu Val Phe Lys Ala Ile Gln
            420                 425                 430         
Asp Val Leu Lys Glu Lys Leu His Lys Arg Gly Val Arg Ile Leu Thr
        435                 440                 445             
Gly Leu Gly Lys Tyr Phe Gln Gln Leu Asp Lys Glu Gly Asn Gly Leu
    450                 455                 460                 
Leu Asp Lys Ala Asp Phe Lys Gln Ala Leu Lys Val Phe His Leu Glu
465                 470                 475                 480 
Val Ser Glu Lys Asp Phe Glu Ser Ala Trp Leu Ile Leu Asn Asp Asn
                485                 490                 495     
Gly Asn Gly Lys Val Asp Tyr Gly Glu Phe Lys Arg Gly Ile Ile Gly
            500                 505                 510         
Glu Met Asn Glu Tyr Arg Lys Ser Tyr Val Arg Lys Ala Phe Met Lys
        515                 520                 525             
Leu Asp Phe Asn Lys Ser Gly Ser Val Pro Ile Ile Asn Ile Arg Lys
    530                 535                 540                 
Cys Tyr Cys Ala Lys Lys His Ser Gln Val Ile Ser Gly
545                 550                 555         


<210> 7684
<211> 791
<212> PRT
<213> Homo sapiens

<400> 7684
Met Ser Asn Arg Gln Glu Lys Tyr Glu Ala Gln Asn Ile Val Asn Ser
 1               5                  10                  15      
Thr Glu Glu Ser Asp Asp Ala Phe Asp Thr Val Thr Ile Pro Val Pro
            20                  25                  30          
Ser Glu Glu Pro Gln Glu Ser Asp Gln Thr Glu Glu His Glu Ser Gly
        35                  40                  45              
Ile Glu Gln Phe Ser Glu Ser His Ala Ile His Val Glu Glu Gln Ser
    50                  55                  60                  
Asp Gln Ser Phe Ser Ser Leu Glu Pro Asp Asn Glu Gln Leu Met Glu
65                  70                  75                  80  
Glu Val Ile Ser Pro Arg Gln Val Ser Tyr Thr Pro Gln His His Glu
                85                  90                  95      
Lys Gln Tyr Ala Met Gln Arg Pro Asn Asp Asp Ser Leu Ala Phe Leu
            100                 105                 110         
Asp Lys Ile Lys Ser Val Lys Glu Ser Leu Gln Glu Ser Val Glu Asp
        115                 120                 125             
Ser Leu Ala Thr Val Lys Val Val Leu Ile Pro Val Gly Gln Glu Ile
    130                 135                 140                 
Val Ile Pro Phe Lys Val Asp Thr Ile Leu Lys Tyr Leu Lys Asp His
145                 150                 155                 160 
Phe Ser His Leu Leu Gly Ile Pro His Ser Val Leu Gln Ile Arg Tyr
                165                 170                 175     
Ser Gly Lys Ile Leu Lys Asn Asn Glu Thr Leu Val Gln His Gly Val
            180                 185                 190         
Lys Pro Gln Glu Ile Val Gln Val Glu Ile Phe Ser Thr Asn Pro Asp
        195                 200                 205             
Leu Tyr Pro Val Arg Arg Ile Asp Gly Leu Thr Asp Val Ser Gln Ile
    210                 215                 220                 
Ile Thr Val Thr Val Gln Thr Gly Leu Asp Gln Tyr Gln Gln Val Pro
225                 230                 235                 240 
Val Glu Ile Val Lys Ser Asp Phe His Lys Pro Ser Leu Gly Gly Phe
                245                 250                 255     
Arg His Lys Val Thr Gly Val Glu Tyr His Asn Ala Gly Thr Gln Thr
            260                 265                 270         
Val Pro Lys Arg Ile Pro Glu Arg Leu Ser Ile Phe Cys Arg Asp Thr
        275                 280                 285             
Gln Thr Val Phe Gln Lys Lys Asn Leu Gln Gln Thr Thr Asn Thr Thr
    290                 295                 300                 
Ser Thr Gln Met Thr Asn Ile Gly Val Tyr Val Ser Asn Met Thr Asp
305                 310                 315                 320 
Lys Leu Val Thr Pro Gly Lys Tyr Phe Ser Ala Ala Glu Tyr His Ala
                325                 330                 335     
Gln Arg Leu Lys Ala Val Thr Val Ile Gln Thr Tyr Tyr Arg Gln Trp
            340                 345                 350         
His Ala Lys Ile Phe Val Glu Asn Leu Arg Arg Gln Lys Ser Leu Arg
        355                 360                 365             
Leu Glu Trp Glu Thr Gln Gln Glu Leu Arg Lys Ile Arg Glu Lys Glu
    370                 375                 380                 
Glu Trp Ile Lys Leu Asp Tyr His Arg Arg His Asn Pro Lys Thr Asn
385                 390                 395                 400 
Glu Asp Phe Glu Phe Leu Tyr Asn Ala Leu Glu Phe Trp Arg Gln Glu
                405                 410                 415     
Glu Leu Thr Arg Ile Asn Gln Ser Phe Thr Gly Ala Glu Arg Lys Ala
            420                 425                 430         
Ala Leu Cys Glu Leu Leu Glu Lys Glu Thr Gln Ile Ile Ala Ser Ile
        435                 440                 445             
Gly Arg His Arg Tyr Ile Ala Tyr Met Ala Asn Gln Glu Ala Ala Ile
    450                 455                 460                 
Gln Ala Phe Leu Asp Lys Cys Ser Ala Pro Lys Ile Trp Arg Thr Pro
465                 470                 475                 480 
Asn Gly Lys Thr Ile Glu Met Asp Thr Gln Phe Thr Ile Arg Ala Arg
                485                 490                 495     
Glu Leu Gln Asn Ile Tyr Lys Cys Ile Met Leu Lys Asn Ile Ser Gln
            500                 505                 510         
Asp Glu Arg Leu Asp Val Leu Leu Thr Leu Lys His Thr Val Lys Glu
        515                 520                 525             
His Glu Cys Lys Leu Thr Gln Glu Ile Leu Glu Leu Ile Asp Arg Glu
    530                 535                 540                 
Val Asp Leu Met Met Arg Gly Val Lys His His Asn Leu Glu Gly Leu
545                 550                 555                 560 
Arg Lys Arg Ile Ala Thr Leu Phe Phe His Tyr Ile Lys Thr Pro Leu
                565                 570                 575     
Phe Asn Pro Glu Val Ala Lys Tyr Leu Lys Val Pro Gln Asp Pro Leu
            580                 585                 590         
Lys Phe Tyr Lys Lys Ile Tyr Phe Cys His Ser Cys Gln Leu Tyr Leu
        595                 600                 605             
Pro Ser Thr Glu Phe Ser Val Ser Ser Thr Ser Arg Arg Ile Tyr Arg
    610                 615                 620                 
Cys Arg Asn Cys Ile Asn Leu Gln Asn Glu Ala Gln Lys Arg Glu Ser
625                 630                 635                 640 
Phe Leu Lys Tyr Lys Cys Leu Leu Gln Gln Leu Tyr Tyr Thr Glu Ala
                645                 650                 655     
Asp Tyr Glu Asp Asp Ser Lys Ile Ala Phe Leu Met Gln Leu Gln Asp
            660                 665                 670         
Ile Gln Tyr Leu Thr Glu Asn Ile Trp Ala Ser Gln Ser Val Leu Ser
        675                 680                 685             
Ala Cys Asp Asn Leu Ser Asp Leu Val Met Val Arg Trp Asn Lys Ser
    690                 695                 700                 
Leu Glu Trp Ser Pro Trp Asn Cys Ile Leu Leu Thr Lys Asp Glu Ala
705                 710                 715                 720 
Ala Ala His Leu Lys Leu Thr Ser Ile Glu Glu Gly Tyr Glu Arg Ser
                725                 730                 735     
Phe Ile His Lys Ile Lys His Lys His Ile Leu Ala Lys Asn Tyr Phe
            740                 745                 750         
Ser Gln Val Pro Val Leu Ala Ser Phe Ile Leu Asp Asp Gly Glu Ile
        755                 760                 765             
Asp Glu Ile Arg Trp Lys Tyr His Ser Asp Thr Thr Pro Lys Ile Ile
    770                 775                 780                 
Glu Ser Gln Arg Pro Pro His
785                 790     


<210> 7685
<211> 317
<212> PRT
<213> Homo sapiens

<400> 7685
Met Asn Leu Asn Thr Ser Ser Asn Thr Gly Asp Thr Gln Arg Leu Lys
 1               5                  10                  15      
Ile Ala Ser Leu Asp Val Lys Gln Ile Leu Lys Asn Glu Thr Glu Leu
            20                  25                  30          
Asp Ile Thr Asp Asn Leu Arg Lys Lys Leu His Trp Ala Lys Lys Glu
        35                  40                  45              
Lys Leu Glu Ile Thr Thr Lys His Asn Ala Glu Leu Ala Ser Tyr Glu
    50                  55                  60                  
Ser Gln Ile Ala Lys Leu Arg Ser Glu Val Glu Lys Gly Glu Ala Leu
65                  70                  75                  80  
Arg Gln Ser Leu Glu Tyr Asp Leu Ala Val Ala Arg Lys Glu Ala Gly
                85                  90                  95      
Leu Gly Arg Arg Ala Ala Glu Glu Arg Leu Ala Glu Ala His Arg Ile
            100                 105                 110         
Gln Glu Lys Leu Cys Ala Gln Asn Ser Glu Leu Gln Ala Lys Thr Asn
        115                 120                 125             
Glu Thr Glu Lys Ala Phe Gln Thr Ser Gln Gln Lys Trp Lys Glu Glu
    130                 135                 140                 
Cys Arg Arg Phe Glu His Asp Leu Glu Glu Arg Asp Asn Met Ile Gln
145                 150                 155                 160 
Asn Cys Asn Arg Glu Tyr Asp Leu Leu Met Lys Glu Lys Ser Arg Leu
                165                 170                 175     
Glu Lys Thr Leu Gln Glu Ala Leu Glu Lys His Gln Arg Glu Lys Asn
            180                 185                 190         
Glu Met Glu Ser His Ile Arg Glu Thr Ala Leu Glu Glu Phe Arg Leu
        195                 200                 205             
Gln Glu Glu Gln Trp Glu Ala Glu Arg Arg Glu Leu Gln Phe Ile Val
    210                 215                 220                 
Gln Glu Gln Asp Thr Ala Val Gln Asn Met His Lys Lys Val Glu Lys
225                 230                 235                 240 
Leu Glu Thr Glu His Met Asp Cys Ser Asp Leu Leu Arg Arg Gln Thr
                245                 250                 255     
Ser Glu Leu Glu Phe Ser Thr Gln Arg Glu Glu Arg Leu Arg Lys Glu
            260                 265                 270         
Phe Glu Ala Thr Thr Leu Arg Val Arg Lys Leu Glu Glu Asn Ile Glu
        275                 280                 285             
Ala Glu Arg Ala Ala His Leu Glu Ser Lys Phe Asn Ser Glu Ile Ile
    290                 295                 300                 
Gln Val Lys Cys Lys Gln Ile Phe Trp Pro Ala Phe Ser
305                 310                 315         


<210> 7686
<211> 189
<212> PRT
<213> Homo sapiens

<400> 7686
Met Asp Asp Asp Gly Leu Pro Leu Met Gly Ser Gly Asp Leu Thr Lys
 1               5                  10                  15      
Val Pro Thr Leu Gln Gln Lys Arg Thr Val Ala Phe Leu Asn Gln Phe
            20                  25                  30          
Val Val His Thr Val Glu Phe Leu Asn Cys Phe Ser Thr Val Cys Glu
        35                  40                  45              
Glu Lys Leu Ala Asp Leu Cys Leu Cys Ile Gln Gln Ile Glu Thr Thr
    50                  55                  60                  
Leu Asn Ile Leu Asp Thr Lys Leu Ser Ser Val Ser Asp Leu Asp Asp
65                  70                  75                  80  
Val Thr Val Glu Val Ser Pro Leu Ser Val Thr Ser Val Thr Asn Gly
                85                  90                  95      
Ala His Ser Glu Ala Thr Ser Glu Gln Leu Gln Asn Ser Thr Gln Asp
            100                 105                 110         
Ser Gly Pro Gln Glu Ser Glu Gly Ser Ala Gly Asn Ser Leu Thr Val
        115                 120                 125             
Ala Lys Asp Pro Arg Tyr Ala Arg Asn Leu Lys Ile Ala Gln Val Gly
    130                 135                 140                 
Val Pro Ala Met Ala Ile Lys Asn Lys Ile Lys Gly Leu Val Pro Asp
145                 150                 155                 160 
Leu Pro Glu Arg Pro Asp Ala Pro Val Pro Asp Gly Glu Ser Glu Lys
                165                 170                 175     
Ile Glu Glu Ser Ser Asp Ser Glu Ser Ser Phe Ser Asn
            180                 185                 


<210> 7687
<211> 240
<212> PRT
<213> Homo sapiens

<400> 7687
Met Ala Glu Tyr Leu Ala Ser Ile Phe Gly Thr Glu Lys Asp Lys Val
 1               5                  10                  15      
Asn Cys Ser Phe Tyr Phe Lys Ile Gly Ala Cys Arg His Gly Asp Arg
            20                  25                  30          
Cys Ser Arg Leu His Asn Lys Pro Thr Phe Ser Gln Thr Ile Ala Leu
        35                  40                  45              
Leu Asn Ile Tyr Arg Asn Pro Gln Asn Ser Ser Gln Ser Ala Asp Gly
    50                  55                  60                  
Leu Arg Cys Ala Val Ser Asp Val Glu Met Gln Glu His Tyr Asp Glu
65                  70                  75                  80  
Phe Phe Glu Glu Val Phe Thr Glu Met Glu Glu Lys Tyr Gly Glu Val
                85                  90                  95      
Glu Glu Met Asn Val Cys Asp Asn Leu Gly Asp His Leu Val Gly Asn
            100                 105                 110         
Val Tyr Val Lys Phe Arg Arg Glu Glu Asp Ala Glu Lys Ala Val Ile
        115                 120                 125             
Asp Leu Asn Asn Arg Trp Phe Asn Gly Gln Pro Ile His Ala Glu Leu
    130                 135                 140                 
Ser Pro Val Thr Asp Phe Arg Glu Ala Cys Cys Arg Gln Tyr Glu Met
145                 150                 155                 160 
Gly Glu Cys Thr Arg Gly Gly Phe Cys Asn Phe Met His Leu Lys Pro
                165                 170                 175     
Ile Ser Arg Glu Leu Arg Arg Glu Leu Tyr Gly Arg Arg Arg Lys Lys
            180                 185                 190         
His Arg Ser Arg Ser Arg Ser Arg Glu Arg Arg Ser Arg Ser Arg Asp
        195                 200                 205             
Arg Gly Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg
    210                 215                 220                 
Glu Arg Asp Arg Arg Arg Ser Arg Asp Arg Glu Arg Ser Gly Arg Phe
225                 230                 235                 240 


<210> 7688
<211> 920
<212> PRT
<213> Homo sapiens

<400> 7688
Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg
 1               5                  10                  15      
Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys
            20                  25                  30          
Arg Tyr Ser Ser Arg Ser Arg Ser Arg Thr Tyr Ser Arg Ser Arg Ser
        35                  40                  45              
Arg Asp Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn
    50                  55                  60                  
Arg Gly Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr
65                  70                  75                  80  
Tyr Gln Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val
                85                  90                  95      
Trp Asn Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser
            100                 105                 110         
Arg Ser Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg
        115                 120                 125             
Ser Arg Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser
    130                 135                 140                 
Arg Ser Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly
145                 150                 155                 160 
Ser Gln Glu Lys Gln Thr Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu
                165                 170                 175     
Ser Pro Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Thr Phe Glu
            180                 185                 190         
His Asp Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Thr
        195                 200                 205             
Ser Gly Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg
    210                 215                 220                 
Ser Pro His Ser Pro Ser Pro Ile Ala Thr Pro Pro Ser Gln Ser Ser
225                 230                 235                 240 
Ser Cys Ser Asp Ala Pro Met Leu Ser Thr Val His Ser Ala Lys Asn
                245                 250                 255     
Thr Pro Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser
            260                 265                 270         
Gly Ser Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln
        275                 280                 285             
Asn Ser Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Thr
    290                 295                 300                 
Ile Ala Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser
305                 310                 315                 320 
Phe Tyr Pro Asp Gly Gly Asp Gln Glu Thr Ala Lys Thr Gly Lys Phe
                325                 330                 335     
Leu Lys Arg Phe Thr Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg
            340                 345                 350         
Gly Asn Thr Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys
        355                 360                 365             
Gly Arg Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe
    370                 375                 380                 
Ser Asp Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp
385                 390                 395                 400 
Asp Thr Glu Glu Thr Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu
                405                 410                 415     
Ala Asp Gln Gly Lys Ser Phe Ala Thr Ala Ser His Arg Asn Thr Glu
            420                 425                 430         
Glu Glu Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg
        435                 440                 445             
Glu Ser Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Thr
    450                 455                 460                 
Gly Tyr Val Val Glu Arg Pro Ser Thr Thr Lys Asp Lys His Lys Glu
465                 470                 475                 480 
Glu Asp Lys Asn Ser Glu Arg Ile Thr Val Lys Lys Glu Thr Gln Ser
                485                 490                 495     
Pro Glu Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser
            500                 505                 510         
Pro Pro Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Thr Phe Arg
        515                 520                 525             
Glu Glu Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg
    530                 535                 540                 
Pro Glu Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn
545                 550                 555                 560 
Arg Pro Ala Ser Leu Thr Lys Asp Arg Leu Leu Ala Ser Thr Leu Val
                565                 570                 575     
His Ser Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile
            580                 585                 590         
Lys Leu Pro Gln Ala Ser Lys Ser Thr Ser Glu Ser Phe Ile Gln His
        595                 600                 605             
Ile Val Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala
    610                 615                 620                 
Ala Met Thr Leu Asn Glu Arg Phe Thr Ser Tyr Gln Lys Ala Thr Glu
625                 630                 635                 640 
Glu His Ser Thr Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp
                645                 650                 655     
Ile Ser Pro Ser Thr Leu Arg Lys His Thr Arg Leu Ala Gly Glu Glu
            660                 665                 670         
Arg Val Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys
        675                 680                 685             
Asp Ser Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg
    690                 695                 700                 
Ser Lys Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser
705                 710                 715                 720 
Arg Lys Gln Glu Lys Thr Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr
                725                 730                 735     
Lys Asp Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser
            740                 745                 750         
Ser Ser Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu
        755                 760                 765             
Ser Lys Lys Glu Arg Glu Glu Glu Phe Lys Thr His His Glu Met Lys
    770                 775                 780                 
Glu Tyr Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Thr Phe Phe
785                 790                 795                 800 
Arg Ile Arg Gly Arg Gly Arg Ala Arg Gly Val Phe Ala Gly Thr Asn
                805                 810                 815     
Thr Gly Pro Asn Asn Ser Asn Thr Thr Phe Gln Lys Arg Pro Lys Glu
            820                 825                 830         
Glu Glu Trp Asp Pro Glu Tyr Thr Pro Lys Ser Lys Lys Tyr Phe Leu
        835                 840                 845             
His Asp Asp Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg
    850                 855                 860                 
Gly Arg Gly Thr Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys
865                 870                 875                 880 
Ser Gly Ser Ser Pro Lys Trp Thr His Asp Lys Tyr Gln Gly Asp Gly
                885                 890                 895     
Ile Val Glu Asp Glu Glu Glu Thr Met Glu Asn Asn Glu Glu Lys Lys
            900                 905                 910         
Asp Arg Arg Lys Glu Glu Lys Glu
        915                 920 


<210> 7689
<211> 869
<212> PRT
<213> Homo sapiens

<400> 7689
Met Gly Arg Ala Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg
 1               5                  10                  15      
Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys
            20                  25                  30          
Arg Tyr Arg Ser Arg Ser Arg Thr Tyr Ser Arg Ser Arg Ser Arg Asp
        35                  40                  45              
Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn Arg Gly
    50                  55                  60                  
Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr Tyr Gln
65                  70                  75                  80  
Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val Trp Asn
                85                  90                  95      
Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg Ser
            100                 105                 110         
Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg Ser Arg
        115                 120                 125             
Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser Arg Ser
    130                 135                 140                 
Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly Ser Gln
145                 150                 155                 160 
Glu Lys Gln Thr Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu Ser Pro
                165                 170                 175     
Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Thr Phe Glu His Asp
            180                 185                 190         
Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Thr Ser Gly
        195                 200                 205             
Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg Ser Pro
    210                 215                 220                 
His Ser Pro Ser Pro Ile Ala Thr Pro Pro Ser Gln Ser Ser Ser Cys
225                 230                 235                 240 
Ser Asp Ala Pro Met Leu Ser Thr Val His Ser Ala Lys Asn Thr Pro
                245                 250                 255     
Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser Gly Ser
            260                 265                 270         
Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln Asn Ser
        275                 280                 285             
Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Thr Ile Ala
    290                 295                 300                 
Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser Phe Tyr
305                 310                 315                 320 
Pro Asp Gly Gly Asp Gln Glu Thr Ala Lys Thr Gly Lys Phe Leu Lys
                325                 330                 335     
Arg Phe Thr Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg Gly Asn
            340                 345                 350         
Thr Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys Gly Arg
        355                 360                 365             
Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe Ser Asp
    370                 375                 380                 
Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp Asp Thr
385                 390                 395                 400 
Glu Glu Thr Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu Ala Asp
                405                 410                 415     
Gln Gly Lys Ser Phe Ala Thr Ala Ser His Arg Asn Thr Glu Glu Glu
            420                 425                 430         
Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg Glu Ser
        435                 440                 445             
Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Thr Gly Tyr
    450                 455                 460                 
Val Val Glu Arg Pro Ser Thr Thr Lys Asp Lys His Lys Glu Glu Asp
465                 470                 475                 480 
Lys Asn Ser Glu Arg Ile Thr Val Lys Lys Glu Thr Gln Ser Pro Glu
                485                 490                 495     
Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser Pro Pro
            500                 505                 510         
Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Thr Phe Arg Glu Glu
        515                 520                 525             
Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg Pro Glu
    530                 535                 540                 
Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn Arg Pro
545                 550                 555                 560 
Ala Ser Leu Thr Lys Asp Arg Leu Leu Ala Ser Thr Leu Val His Ser
                565                 570                 575     
Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile Lys Leu
            580                 585                 590         
Pro Gln Ala Ser Lys Ser Thr Ser Glu Ser Phe Ile Gln His Ile Val
        595                 600                 605             
Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala Ala Met
    610                 615                 620                 
Thr Leu Asn Glu Arg Phe Thr Ser Tyr Gln Lys Ala Thr Glu Glu His
625                 630                 635                 640 
Ser Thr Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp Ile Ser
                645                 650                 655     
Pro Ser Thr Leu Arg Lys His Thr Arg Leu Ala Gly Glu Glu Arg Val
            660                 665                 670         
Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys Asp Ser
        675                 680                 685             
Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg Ser Lys
    690                 695                 700                 
Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser Arg Lys
705                 710                 715                 720 
Gln Glu Lys Thr Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr Lys Asp
                725                 730                 735     
Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser Ser Ser
            740                 745                 750         
Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu Ser Lys
        755                 760                 765             
Lys Glu Arg Glu Glu Glu Phe Lys Thr His His Glu Met Lys Glu Tyr
    770                 775                 780                 
Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Thr Phe His Asp Asp
785                 790                 795                 800 
Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg Gly Arg Gly
                805                 810                 815     
Thr Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys Ser Gly Ser
            820                 825                 830         
Ser Pro Lys Trp Thr His Asp Lys Tyr Gln Gly Asp Gly Ile Val Glu
        835                 840                 845             
Asp Glu Glu Glu Thr Met Glu Asn Asn Glu Glu Lys Lys Asp Arg Arg
    850                 855                 860                 
Lys Glu Glu Lys Glu
865                 


<210> 7690
<211> 838
<212> PRT
<213> Homo sapiens

<400> 7690
Met Thr Gly Ala Glu Ile Glu Pro Ser Ala Gln Ala Lys Pro Glu Lys
 1               5                  10                  15      
Lys Ala Gly Glu Glu Val Ile Ala Gly Pro Glu Arg Glu Asn Asp Val
            20                  25                  30          
Pro Leu Val Val Arg Pro Lys Val Arg Thr Gln Ala Thr Thr Gly Ala
        35                  40                  45              
Arg Pro Lys Thr Glu Thr Lys Ser Val Pro Ala Ala Arg Pro Lys Thr
    50                  55                  60                  
Glu Ala Gln Ala Met Ser Gly Ala Arg Pro Lys Thr Glu Val Gln Val
65                  70                  75                  80  
Met Gly Gly Ala Arg Pro Lys Thr Glu Ala Gln Gly Ile Thr Gly Ala
                85                  90                  95      
Arg Pro Lys Thr Asp Ala Arg Ala Val Gly Gly Ala Arg Ser Lys Thr
            100                 105                 110         
Asp Ala Lys Ala Ile Pro Gly Ala Arg Pro Lys Asp Glu Ala Gln Ala
        115                 120                 125             
Trp Ala Gln Ser Glu Phe Gly Thr Glu Ala Val Ser Gln Ala Glu Gly
    130                 135                 140                 
Val Ser Gln Thr Asn Ala Val Ala Trp Pro Leu Ala Thr Ala Glu Ser
145                 150                 155                 160 
Gly Ser Val Thr Lys Ser Lys Gly Leu Ser Met Asp Arg Glu Leu Val
                165                 170                 175     
Asn Val Asp Ala Glu Thr Phe Pro Gly Thr Gln Gly Gln Lys Gly Ile
            180                 185                 190         
Gln Pro Trp Phe Gly Pro Gly Glu Glu Thr Asn Met Gly Ser Trp Cys
        195                 200                 205             
Tyr Ser Arg Pro Arg Ala Arg Glu Glu Ala Ser Asn Glu Ser Gly Phe
    210                 215                 220                 
Trp Ser Ala Asp Glu Thr Ser Thr Ala Ser Ser Phe Trp Thr Gly Glu
225                 230                 235                 240 
Glu Thr Ser Val Arg Ser Trp Pro Arg Glu Glu Ser Asn Thr Arg Ser
                245                 250                 255     
Arg His Arg Ala Lys His Gln Thr Asn Pro Arg Ser Arg Pro Arg Ser
            260                 265                 270         
Lys Gln Glu Ala Tyr Val Asp Ser Trp Ser Gly Ser Glu Asp Glu Ala
        275                 280                 285             
Ser Asn Pro Phe Ser Phe Trp Val Gly Glu Asn Thr Asn Asn Leu Phe
    290                 295                 300                 
Arg Pro Arg Val Arg Glu Glu Ala Asn Ile Arg Ser Lys Leu Arg Thr
305                 310                 315                 320 
Asn Arg Glu Asp Cys Phe Glu Ser Glu Ser Glu Asp Glu Phe Tyr Lys
                325                 330                 335     
Gln Ser Trp Val Leu Pro Gly Glu Glu Ala Asn Ser Arg Phe Arg His
            340                 345                 350         
Arg Asp Lys Glu Asp Pro Asn Thr Ala Leu Lys Leu Arg Ala Gln Lys
        355                 360                 365             
Asp Val Asp Ser Asp Arg Val Lys Gln Glu Pro Arg Phe Glu Glu Glu
    370                 375                 380                 
Val Ile Ile Gly Ser Trp Phe Trp Ala Glu Lys Glu Ala Ser Leu Glu
385                 390                 395                 400 
Gly Gly Ala Ser Ala Ile Cys Glu Ser Glu Pro Gly Thr Glu Glu Gly
                405                 410                 415     
Ala Ile Gly Gly Ser Ala Tyr Trp Ala Glu Glu Lys Ser Ser Leu Gly
            420                 425                 430         
Ala Val Ala Arg Glu Glu Ala Lys Pro Glu Ser Glu Glu Glu Ala Ile
        435                 440                 445             
Phe Gly Ser Trp Phe Trp Asp Arg Asp Glu Ala Cys Phe Asp Leu Asn
    450                 455                 460                 
Pro Cys Pro Val Tyr Lys Val Ser Asp Arg Phe Arg Asp Ala Ala Glu
465                 470                 475                 480 
Glu Leu Asn Ala Ser Ser Arg Pro Gln Thr Trp Asp Glu Val Thr Val
                485                 490                 495     
Glu Phe Lys Pro Gly Leu Phe His Gly Val Gly Phe Arg Ser Thr Ser
            500                 505                 510         
Pro Phe Gly Ile Pro Glu Glu Ala Ser Glu Met Leu Glu Ala Lys Pro
        515                 520                 525             
Lys Asn Leu Glu Leu Ser Pro Glu Gly Glu Glu Gln Glu Ser Leu Leu
    530                 535                 540                 
Gln Pro Asp Gln Pro Ser Pro Glu Phe Thr Phe Gln Tyr Asp Pro Ser
545                 550                 555                 560 
Tyr Arg Ser Val Arg Glu Ile Arg Glu His Leu Arg Ala Arg Glu Ser
                565                 570                 575     
Ala Glu Ser Glu Ser Trp Ser Cys Ser Cys Ile Gln Cys Glu Leu Lys
            580                 585                 590         
Ile Gly Ser Glu Glu Phe Glu Glu Phe Leu Leu Leu Met Asp Lys Ile
        595                 600                 605             
Arg Asp Pro Phe Ile His Glu Ile Ser Lys Ile Ala Met Gly Met Arg
    610                 615                 620                 
Ser Ala Ser Gln Phe Thr Arg Asp Phe Ile Arg Asp Ser Gly Val Val
625                 630                 635                 640 
Ser Leu Ile Glu Thr Leu Leu Asn Tyr Pro Ser Ser Arg Val Arg Thr
                645                 650                 655     
Ser Phe Leu Glu Asn Met Ile His Met Ala Pro Pro Tyr Pro Asn Leu
            660                 665                 670         
Asn Met Ile Glu Thr Phe Ile Cys Gln Val Cys Glu Glu Thr Leu Ala
        675                 680                 685             
His Ser Val Asp Ser Leu Glu Gln Leu Thr Gly Ile Arg Met Leu Arg
    690                 695                 700                 
His Leu Thr Met Thr Ile Asp Tyr His Thr Leu Ile Ala Asn Tyr Met
705                 710                 715                 720 
Ser Gly Phe Leu Ser Leu Leu Thr Thr Ala Asn Ala Arg Thr Lys Phe
                725                 730                 735     
His Val Leu Lys Met Leu Leu Asn Leu Ser Glu Asn Pro Ala Val Ala
            740                 745                 750         
Lys Lys Leu Phe Ser Ala Lys Ala Leu Ser Ile Phe Val Gly Leu Phe
        755                 760                 765             
Asn Ile Glu Glu Thr Asn Asp Asn Ile Gln Ile Val Ile Lys Met Phe
    770                 775                 780                 
Gln Asn Ile Ser Asn Ile Ile Lys Ser Gly Lys Met Ser Leu Ile Asp
785                 790                 795                 800 
Asp Asp Phe Ser Leu Glu Pro Leu Ile Ser Ala Phe Arg Glu Phe Glu
                805                 810                 815     
Glu Leu Ala Lys Gln Leu Gln Ala Gln Ile Asp Asn Gln Asn Asp Pro
            820                 825                 830         
Glu Val Gly Gln Gln Ser
        835             


<210> 7691
<211> 687
<212> PRT
<213> Homo sapiens

<400> 7691
His Ile Glu His Val Val Leu Asn Gln Lys Asn Met Thr Leu Ser Asn
 1               5                  10                  15      
Arg Cys Gln Val Phe Asp Arg Phe Gln Asp Thr Val Ser Gln His Val
            20                  25                  30          
Val Lys Val Asp Phe Leu Asn Arg Ile His Lys Lys His Pro Pro Asn
        35                  40                  45              
Arg Arg Val Leu Gln Ser Val Lys Arg Arg Ser Leu Lys Val Pro Asp
    50                  55                  60                  
Ala Ile Lys Ser Gln Tyr Gln Phe Pro Pro Pro Leu Ile Ala Pro Ala
65                  70                  75                  80  
Ala Ile Arg Asp Gly Glu Leu Ile Cys Asn Gly Ile Pro Glu Glu Ser
                85                  90                  95      
Gln Met His Leu Leu Asn Ser Glu His Leu Ala Thr Gln Ala Glu Gln
            100                 105                 110         
Gln Glu Trp Leu Cys Ser Val Val Ala Leu Gln Cys Ser Ile Leu Lys
        115                 120                 125             
His Leu Ser Ala Lys Gln Met Pro Ser His Trp Asp Ser Glu Gln Thr
    130                 135                 140                 
Glu Lys Ala Asp Ile Lys Pro Val Ile Val Thr Asp Ser Ser Val Thr
145                 150                 155                 160 
Thr Ser Leu Gln Thr Ala Asp Lys Thr Pro Thr Pro Ser His Tyr Pro
                165                 170                 175     
Leu Ser Cys Pro Ser Gly Ile Ser Thr Gln Asn Ser Leu Ser Cys Ser
            180                 185                 190         
Pro Pro His Gln Ser Pro Ala Leu Glu Asp Ile Gly Cys Ser Ser Cys
        195                 200                 205             
Ala Glu Lys Ser Lys Lys Thr Pro Cys Gly Thr Ala Asn Gly Pro Val
    210                 215                 220                 
Asn Thr Glu Val Lys Ala Asn Gly Pro His Leu Tyr Ser Ser Pro Thr
225                 230                 235                 240 
Asp Ser Thr Asp Pro Arg Arg Leu Pro Gly Ala Asn Thr Pro Leu Pro
                245                 250                 255     
Gly Leu Ser His Arg Gln Gly Trp Pro Arg Pro Leu Thr Pro Pro Ala
            260                 265                 270         
Ala Gly Gly Leu Gln Asn His Thr Val Gly Ile Ile Val Lys Thr Glu
        275                 280                 285             
Asn Ala Thr Gly Pro Ser Ser Cys Pro Gln Arg Ser Leu Val Pro Val
    290                 295                 300                 
Pro Ser Leu Pro Pro Ser Ile Pro Ser Ser Cys Ala Ser Ile Glu Asn
305                 310                 315                 320 
Thr Ser Thr Leu Gln Arg Lys Thr Val Gln Ser Gln Ile Gly Pro Pro
                325                 330                 335     
Leu Thr Asp Ser Arg Pro Leu Gly Ser Pro Pro Asn Ala Thr Arg Val
            340                 345                 350         
Leu Thr Pro Pro Gln Ala Ala Gly Asp Gly Ile Leu Ala Thr Thr Ala
        355                 360                 365             
Asn Gln Arg Phe Ser Ser Pro Ala Pro Ser Ser Asp Gly Lys Val Ser
    370                 375                 380                 
Pro Gly Thr Leu Ser Ile Gly Ser Ala Leu Thr Val Pro Ser Phe Pro
385                 390                 395                 400 
Ala Asn Ser Thr Ala Met Val Asp Leu Thr Asn Ser Leu Arg Ala Phe
                405                 410                 415     
Met Asp Val Asn Gly Glu Ile Glu Ile Asn Met Leu Asp Glu Lys Leu
            420                 425                 430         
Ile Lys Phe Leu Ala Leu Gln Arg Ile His Gln Leu Phe Pro Ser Arg
        435                 440                 445             
Val Gln Pro Ser Pro Gly Ser Val Gly Thr His Gln Leu Ala Ser Gly
    450                 455                 460                 
Gly His His Ile Glu Val Gln Arg Lys Glu Val Gln Ala Arg Ala Val
465                 470                 475                 480 
Phe Tyr Pro Leu Leu Gly Leu Gly Gly Ala Val Asn Met Cys Tyr Arg
                485                 490                 495     
Thr Leu Tyr Ile Gly Thr Gly Ala Asp Met Asp Val Cys Leu Thr Asn
            500                 505                 510         
Tyr Gly His Cys Asn Tyr Val Ser Gly Lys His Ala Cys Ile Phe Tyr
        515                 520                 525             
Asp Glu Asn Thr Lys His Tyr Glu Leu Leu Asn Tyr Ser Glu His Gly
    530                 535                 540                 
Thr Thr Val Asp Asn Val Leu Tyr Ser Cys Asp Phe Ser Glu Lys Thr
545                 550                 555                 560 
Pro Pro Thr Pro Pro Ser Ser Ile Val Ala Lys Val Gln Ser Val Ile
                565                 570                 575     
Arg Arg Arg Arg His Gln Lys Gln Asp Glu Glu Pro Ser Glu Glu Ala
            580                 585                 590         
Ala Met Met Ser Ser Gln Ala Gln Gly Pro Gln Arg Arg Pro Cys Asn
        595                 600                 605             
Cys Lys Ala Ser Ser Ser Ser Leu Ile Gly Gly Ser Gly Ala Gly Trp
    610                 615                 620                 
Glu Gly Thr Ala Leu Leu His His Gly Ser Tyr Ile Lys Leu Gly Cys
625                 630                 635                 640 
Leu Gln Phe Val Phe Ser Ile Thr Glu Phe Ala Thr Lys Gln Pro Lys
                645                 650                 655     
Gly Asp Ala Ser Leu Leu Gln Asp Gly Val Leu Ala Glu Lys Leu Ser
            660                 665                 670         
Leu Lys Pro His Gln Gly Pro Val Leu Arg Ser Asn Ser Val Pro
        675                 680                 685         


<210> 7692
<211> 704
<212> PRT
<213> Homo sapiens

<400> 7692
Met Trp Glu Lys Met Glu Thr Lys Thr Ile Val Tyr Asp Leu Asp Thr
 1               5                  10                  15      
Ser Gly Gly Leu Met Glu Gln Ile Gln Ala Leu Leu Ala Pro Pro Lys
            20                  25                  30          
Thr Asp Glu Ala Glu Lys Arg Ser Arg Lys Pro Glu Lys Glu Pro Arg
        35                  40                  45              
Arg Ser Gly Arg Ala Thr Asn His Asp Ser Cys Asp Ser Cys Lys Glu
    50                  55                  60                  
Gly Gly Asp Leu Leu Cys Cys Asp His Cys Pro Ala Ala Phe His Leu
65                  70                  75                  80  
Gln Cys Cys Asn Pro Pro Leu Ser Glu Glu Met Leu Pro Pro Gly Glu
                85                  90                  95      
Trp Met Cys His Arg Cys Thr Val Arg Arg Lys Lys Arg Glu Gln Lys
            100                 105                 110         
Lys Glu Leu Gly His Val Asn Gly Leu Val Asp Lys Ser Gly Lys Arg
        115                 120                 125             
Thr Thr Ser Pro Ser Ser Asp Thr Asp Leu Leu Asp Arg Ser Ala Ser
    130                 135                 140                 
Lys Thr Glu Leu Lys Ala Ile Ala His Ala Arg Ile Leu Glu Arg Arg
145                 150                 155                 160 
Ala Ser Arg Pro Gly Thr Pro Thr Ser Ser Ala Ser Thr Glu Thr Pro
                165                 170                 175     
Thr Ser Glu Gln Asn Asp Val Asp Glu Asp Ile Ile Asp Val Asp Glu
            180                 185                 190         
Glu Pro Val Ala Ala Glu Pro Asp Tyr Val Gln Pro Gln Leu Arg Arg
        195                 200                 205             
Pro Phe Glu Leu Leu Ile Ala Ala Ala Met Glu Arg Asn Pro Thr Gln
    210                 215                 220                 
Phe Gln Leu Pro Asn Glu Leu Thr Cys Thr Thr Ala Leu Pro Gly Ser
225                 230                 235                 240 
Ser Lys Arg Arg Arg Lys Glu Glu Thr Thr Gly Lys Asn Val Lys Lys
                245                 250                 255     
Thr Gln His Glu Leu Asp His Asn Gly Leu Val Pro Leu Pro Val Lys
            260                 265                 270         
Val Cys Phe Thr Cys Asn Arg Ser Cys Arg Val Ala Pro Leu Ile Gln
        275                 280                 285             
Cys Asp Tyr Cys Pro Leu Leu Phe His Met Asp Cys Leu Glu Pro Pro
    290                 295                 300                 
Leu Thr Ala Met Pro Leu Gly Arg Trp Met Cys Pro Asn His Ile Glu
305                 310                 315                 320 
His Val Val Leu Asn Gln Lys Asn Met Thr Leu Ser Asn Arg Cys Gln
                325                 330                 335     
Val Phe Asp Arg Phe Gln Asp Thr Val Ser Gln His Val Val Lys Val
            340                 345                 350         
Asp Phe Leu Asn Arg Ile His Lys Lys His Pro Pro Asn Arg Arg Val
        355                 360                 365             
Leu Gln Ser Val Lys Arg Arg Ser Leu Lys Val Pro Asp Ala Ile Lys
    370                 375                 380                 
Ser Gln Tyr Gln Phe Pro Pro Pro Leu Ile Ala Pro Ala Ala Ile Arg
385                 390                 395                 400 
Asp Gly Glu Leu Ile Cys Asn Gly Ile Pro Glu Glu Ser Gln Met His
                405                 410                 415     
Leu Leu Asn Ser Glu His Leu Ala Thr Gln Ala Glu Gln Gln Glu Trp
            420                 425                 430         
Leu Cys Ser Val Val Ala Leu Gln Cys Ser Ile Leu Lys His Leu Ser
        435                 440                 445             
Ala Lys Gln Met Pro Ser His Trp Asp Ser Glu Gln Thr Glu Lys Ala
    450                 455                 460                 
Asp Ile Lys Pro Val Ile Val Thr Asp Ser Ser Val Thr Thr Ser Leu
465                 470                 475                 480 
Gln Thr Ala Asp Lys Thr Pro Thr Pro Ser His Tyr Pro Leu Ser Cys
                485                 490                 495     
Pro Ser Gly Ile Ser Thr Gln Asn Ser Leu Ser Cys Ser Pro Pro His
            500                 505                 510         
Gln Ser Pro Ala Leu Glu Asp Ile Gly Cys Ser Ser Cys Ala Glu Lys
        515                 520                 525             
Ser Lys Lys Thr Pro Cys Gly Thr Ala Asn Gly Pro Val Asn Thr Glu
    530                 535                 540                 
Val Lys Ala Asn Gly Pro His Leu Tyr Ser Ser Pro Thr Asp Ser Thr
545                 550                 555                 560 
Asp Pro Arg Arg Leu Pro Gly Ala Asn Thr Pro Leu Pro Gly Leu Ser
                565                 570                 575     
His Arg Gln Gly Trp Pro Arg Pro Leu Thr Pro Pro Ala Ala Gly Gly
            580                 585                 590         
Leu Gln Asn His Thr Val Gly Ile Ile Val Lys Thr Glu Asn Ala Thr
        595                 600                 605             
Gly Pro Ser Ser Cys Pro Gln Arg Ser Leu Val Pro Val Pro Ser Leu
    610                 615                 620                 
Pro Pro Ser Ile Pro Ser Ser Cys Ala Ser Ile Glu Asn Thr Ser Thr
625                 630                 635                 640 
Leu Gln Arg Lys Thr Val Gln Ser Gln Ile Gly Pro Pro Leu Thr Asp
                645                 650                 655     
Ser Arg Pro Leu Gly Ser Pro Pro Asn Ala Thr Arg Val Leu Thr Pro
            660                 665                 670         
Pro Gln Ala Ala Gly Asp Gly Ile Leu Ala Thr Thr Ala Asn Gln Arg
        675                 680                 685             
Phe Ser Ser Pro Ala Pro Ser Ser Gly Glu Cys Cys Ser Ala Leu Gly
    690                 695                 700                 


<210> 7693
<211> 436
<212> PRT
<213> Homo sapiens

<400> 7693
Gly Asn Met Asp Ser Phe Met Ala Gln Val Lys Ser Leu Ala Gln Ser
 1               5                  10                  15      
Leu Tyr Pro Cys Ser Ala Gln Gln Leu Asn Glu Asp Leu Arg Leu His
            20                  25                  30          
Leu Leu Leu Asn Thr Ser Val Thr Cys Asn Asp Gly Ser Pro Ala Gly
        35                  40                  45              
Tyr Tyr Leu Lys Glu Ser Arg Gly Ser Arg Arg Trp Leu Leu Phe Leu
    50                  55                  60                  
Glu Gly Gly Trp Tyr Cys Phe Asn Arg Glu Asn Cys Asp Ser Arg Tyr
65                  70                  75                  80  
Asp Thr Met Arg Arg Leu Met Ser Ser Arg Asp Trp Pro Arg Thr Arg
                85                  90                  95      
Thr Gly Thr Gly Ile Leu Ser Ser Gln Pro Glu Glu Asn Pro Tyr Trp
            100                 105                 110         
Trp Asn Ala Asn Met Val Phe Ile Pro Tyr Cys Ser Ser Asp Val Trp
        115                 120                 125             
Ser Gly Ala Ser Ser Lys Ser Glu Lys Asn Glu Tyr Ala Phe Met Gly
    130                 135                 140                 
Ala Leu Asn Ile Gln Glu Val Val Arg Glu Leu Leu Gly Arg Gly Leu
145                 150                 155                 160 
Ser Gly Ala Lys Val Leu Leu Leu Ala Gly Ser Ser Ala Gly Gly Thr
                165                 170                 175     
Gly Val Leu Leu Asn Val Asp Leu Val Ala Glu Gln Leu Glu Lys Leu
            180                 185                 190         
Gly Tyr Pro Ala Ile Gln Val Arg Gly Leu Ala Asp Ser Gly Trp Phe
        195                 200                 205             
Leu Asp Asn Lys Gln Tyr Arg His Thr Asp Cys Val Asp Thr Ile Thr
    210                 215                 220                 
Cys Ala Pro Thr Glu Ala Ile Arg Arg Gly Ile Arg Tyr Trp Asn Gly
225                 230                 235                 240 
Val Val Pro Glu Arg Cys Arg Arg Gln Phe Gln Glu Gly Glu Glu Trp
                245                 250                 255     
Asn Cys Phe Phe Gly Tyr Lys Val Tyr Pro Thr Leu Arg Cys Pro Val
            260                 265                 270         
Phe Val Val Gln Trp Leu Phe Asp Glu Ala Gln Leu Thr Val Asp Asn
        275                 280                 285             
Val His Leu Thr Gly Gln Pro Val Gln Glu Gly Leu Arg Leu Tyr Ile
    290                 295                 300                 
Gln Asn Leu Gly Arg Glu Leu Arg His Thr Leu Lys Asp Val Pro Ala
305                 310                 315                 320 
Ser Phe Ala Pro Ala Cys Leu Ser His Glu Ile Ile Ile Arg Ser His
                325                 330                 335     
Trp Thr Asp Val Gln Val Lys Gly Thr Ser Leu Pro Arg Ala Leu His
            340                 345                 350         
Cys Trp Asp Arg Ser Leu His Asp Ser His Lys Ala Ser Lys Thr Pro
        355                 360                 365             
Leu Lys Gly Cys Pro Val His Leu Val Asp Ser Cys Pro Trp Pro His
    370                 375                 380                 
Cys Asn Pro Ser Cys Pro Thr Val Arg Asp Gln Phe Thr Gly Gln Glu
385                 390                 395                 400 
Met Asn Val Ala Gln Phe Leu Met His Met Gly Phe Asp Met Gln Thr
                405                 410                 415     
Val Ala Gln Pro Gln Gly Leu Glu Pro Ser Glu Leu Leu Gly Met Leu
            420                 425                 430         
Ser Asn Gly Ser
        435     


<210> 7694
<211> 867
<212> PRT
<213> Homo sapiens

<400> 7694
Met Glu Asn Glu Lys Glu Asn Leu Phe Cys Glu Pro His Lys Arg Gly
 1               5                  10                  15      
Leu Met Lys Thr Pro Leu Lys Glu Ser Thr Thr Ala Asn Ile Val Leu
            20                  25                  30          
Ala Glu Ile Gln Pro Asp Phe Gly Pro Leu Thr Thr Pro Thr Lys Pro
        35                  40                  45              
Lys Glu Gly Ser Gln Gly Glu Pro Trp Thr Pro Thr Ala Asn Leu Lys
    50                  55                  60                  
Met Leu Ile Ser Ala Val Ser Pro Glu Ile Arg Asn Arg Asp Gln Lys
65                  70                  75                  80  
Arg Gly Leu Phe Asp Asn Arg Ser Gly Leu Pro Glu Ala Lys Asp Cys
                85                  90                  95      
Ile His Glu His Leu Ser Gly Asp Glu Phe Glu Lys Ser Gln Pro Ser
            100                 105                 110         
Arg Lys Glu Lys Ser Leu Gly Leu Leu Cys His Lys Phe Leu Ala Arg
        115                 120                 125             
Tyr Pro Asn Tyr Pro Asn Pro Ala Val Asn Asn Asp Ile Cys Leu Asp
    130                 135                 140                 
Glu Val Ala Glu Glu Leu Asn Val Glu Arg Arg Arg Ile Tyr Asp Ile
145                 150                 155                 160 
Val Asn Val Leu Glu Ser Leu His Met Val Ser Arg Leu Ala Lys Asn
                165                 170                 175     
Arg Tyr Thr Trp His Gly Arg His Asn Leu Asn Lys Thr Leu Gly Thr
            180                 185                 190         
Leu Lys Ser Ile Gly Glu Glu Asn Lys Tyr Ala Glu Gln Ile Met Met
        195                 200                 205             
Ile Lys Lys Lys Glu Tyr Glu Gln Glu Phe Asp Phe Ile Lys Ser Tyr
    210                 215                 220                 
Ser Ile Glu Asp His Ile Ile Lys Ser Asn Thr Gly Pro Asn Gly His
225                 230                 235                 240 
Pro Asp Met Cys Phe Val Glu Leu Pro Gly Val Glu Phe Arg Ala Ala
                245                 250                 255     
Ser Val Asn Ser Arg Lys Asp Lys Ser Leu Arg Val Met Ser Gln Lys
            260                 265                 270         
Phe Val Met Leu Phe Leu Val Ser Thr Pro Gln Ile Val Ser Leu Glu
        275                 280                 285             
Val Ala Ala Lys Ile Leu Ile Gly Glu Asp His Val Glu Asp Leu Asp
    290                 295                 300                 
Lys Ser Lys Phe Lys Thr Lys Ile Arg Arg Leu Tyr Asp Ile Ala Asn
305                 310                 315                 320 
Val Leu Ser Ser Leu Asp Leu Ile Lys Lys Val His Val Thr Glu Glu
                325                 330                 335     
Arg Gly Arg Lys Pro Ala Phe Lys Trp Thr Gly Pro Glu Ile Ser Pro
            340                 345                 350         
Asn Thr Ser Gly Ser Ser Pro Val Ile His Phe Thr Pro Ser Asp Leu
        355                 360                 365             
Glu Val Arg Arg Ser Ser Lys Glu Asn Cys Ala Lys Asn Leu Phe Ser
    370                 375                 380                 
Thr Arg Gly Lys Pro Asn Phe Thr Arg His Pro Ser Leu Ile Lys Leu
385                 390                 395                 400 
Val Lys Ser Ile Glu Ser Asp Arg Arg Lys Ile Asn Ser Ala Pro Ser
                405                 410                 415     
Ser Pro Ile Lys Thr Asn Lys Ala Glu Ser Ser Gln Asn Ser Ala Pro
            420                 425                 430         
Phe Pro Ser Lys Met Ala Gln Leu Ala Ala Ile Cys Lys Met Gln Leu
        435                 440                 445             
Glu Glu Gln Ser Ser Glu Ser Arg Gln Lys Val Lys Val Gln Leu Ala
    450                 455                 460                 
Arg Ser Gly Pro Cys Lys Pro Val Ala Pro Leu Asp Pro Pro Val Asn
465                 470                 475                 480 
Ala Glu Met Glu Leu Thr Ala Pro Ser Leu Ile Gln Pro Leu Gly Met
                485                 490                 495     
Val Pro Leu Ile Pro Ser Pro Leu Ser Ser Ala Val Pro Leu Ile Leu
            500                 505                 510         
Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Ile Tyr Leu Gln Pro Thr
        515                 520                 525             
Gln Ala His Gln Ser Val Thr Pro Pro Gln Gly Leu Ser Pro Thr Val
    530                 535                 540                 
Cys Thr Thr His Ser Ser Lys Ala Thr Gly Ser Lys Asp Ser Thr Asp
545                 550                 555                 560 
Ala Thr Thr Glu Lys Ala Ala Asn Asp Thr Ser Lys Ala Ser Ala Ser
                565                 570                 575     
Thr Arg Pro Gly Ser Leu Leu Pro Ala Pro Glu Arg Gln Gly Ala Lys
            580                 585                 590         
Ser Arg Thr Arg Glu Pro Ala Gly Glu Arg Gly Ser Lys Arg Ala Ser
        595                 600                 605             
Met Leu Glu Asp Ser Gly Ser Lys Lys Lys Phe Lys Glu Asp Leu Lys
    610                 615                 620                 
Gly Leu Glu Asn Val Ser Ala Thr Leu Phe Pro Ser Gly Tyr Leu Ile
625                 630                 635                 640 
Pro Leu Thr Gln Cys Ser Ser Leu Gly Ala Glu Ser Ile Leu Ser Gly
                645                 650                 655     
Lys Glu Asn Ser Ser Ala Leu Ser Pro Asn His Arg Ile Tyr Ser Ser
            660                 665                 670         
Pro Ile Ala Gly Val Ile Pro Val Thr Ser Ser Glu Leu Thr Ala Val
        675                 680                 685             
Asn Phe Pro Ser Phe His Val Thr Pro Leu Lys Leu Met Val Ser Pro
    690                 695                 700                 
Thr Ser Val Ala Ala Val Pro Val Gly Asn Ser Pro Ala Leu Ala Ser
705                 710                 715                 720 
Ser His Pro Val Pro Ile Gln Asn Pro Ser Ser Ala Ile Val Asn Phe
                725                 730                 735     
Thr Leu Gln His Leu Gly Leu Ile Ser Pro Asn Val Gln Leu Ser Ala
            740                 745                 750         
Ser Pro Gly Ser Gly Ile Val Pro Val Ser Pro Arg Ile Glu Ser Val
        755                 760                 765             
Asn Val Ala Pro Glu Asn Ala Gly Thr Gln Gln Gly Arg Ala Thr Asn
    770                 775                 780                 
Tyr Asp Ser Pro Val Pro Gly Gln Ser Gln Pro Asn Gly Gln Ser Val
785                 790                 795                 800 
Ala Val Thr Gly Ala Gln Gln Pro Val Pro Val Thr Pro Lys Gly Ser
                805                 810                 815     
Gln Leu Val Ala Glu Ser Phe Phe Arg Thr Pro Gly Gly Pro Thr Lys
            820                 825                 830         
Pro Thr Ser Ser Ser Cys Met Asp Phe Glu Gly Ala Asn Lys Thr Ser
        835                 840                 845             
Leu Gly Thr Leu Phe Val Pro Gln Arg Lys Leu Glu Val Ser Thr Glu
    850                 855                 860                 
Asp Val His
865         


<210> 7695
<211> 736
<212> PRT
<213> Homo sapiens

<400> 7695
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn
 1               5                  10                  15      
Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly
            20                  25                  30          
Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg
        35                  40                  45              
Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile
    50                  55                  60                  
Leu Gln Leu Val His Val Thr Gln Glu Asp Lys Arg Lys Thr Thr Gly
65                  70                  75                  80  
Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr
                85                  90                  95      
Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu
            100                 105                 110         
Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu
        115                 120                 125             
Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu
    130                 135                 140                 
Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys
145                 150                 155                 160 
Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn
                165                 170                 175     
Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala
            180                 185                 190         
Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg
        195                 200                 205             
Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr
    210                 215                 220                 
Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly
225                 230                 235                 240 
Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys
                245                 250                 255     
Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys
            260                 265                 270         
Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr
        275                 280                 285             
Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu
    290                 295                 300                 
Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn
305                 310                 315                 320 
Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu
                325                 330                 335     
Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala
            340                 345                 350         
Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr
        355                 360                 365             
Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu
    370                 375                 380                 
Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr
385                 390                 395                 400 
Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu
                405                 410                 415     
Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val
            420                 425                 430         
Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn
        435                 440                 445             
Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile
    450                 455                 460                 
Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn
465                 470                 475                 480 
Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr
                485                 490                 495     
Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile
            500                 505                 510         
Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val
        515                 520                 525             
Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser
    530                 535                 540                 
Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Leu Ile
545                 550                 555                 560 
Gln Asp Ser Arg Arg Glu Thr Lys Asn Val Ala Ser Gly Gly Gly Gly
                565                 570                 575     
Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met
            580                 585                 590         
Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys
        595                 600                 605             
Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn
    610                 615                 620                 
Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu
625                 630                 635                 640 
Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu
                645                 650                 655     
Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His
            660                 665                 670         
Phe Leu Val Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly
        675                 680                 685             
Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu
    690                 695                 700                 
Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu
705                 710                 715                 720 
Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp
                725                 730                 735     


<210> 7696
<211> 710
<212> PRT
<213> Homo sapiens

<400> 7696
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn
 1               5                  10                  15      
Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly
            20                  25                  30          
Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg
        35                  40                  45              
Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile
    50                  55                  60                  
Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly
65                  70                  75                  80  
Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr
                85                  90                  95      
Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu
            100                 105                 110         
Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu
        115                 120                 125             
Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu
    130                 135                 140                 
Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys
145                 150                 155                 160 
Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn
                165                 170                 175     
Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala
            180                 185                 190         
Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg
        195                 200                 205             
Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr
    210                 215                 220                 
Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly
225                 230                 235                 240 
Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys
                245                 250                 255     
Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys
            260                 265                 270         
Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr
        275                 280                 285             
Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu
    290                 295                 300                 
Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn
305                 310                 315                 320 
Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu
                325                 330                 335     
Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala
            340                 345                 350         
Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr
        355                 360                 365             
Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu
    370                 375                 380                 
Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr
385                 390                 395                 400 
Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu
                405                 410                 415     
Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val
            420                 425                 430         
Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn
        435                 440                 445             
Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile
    450                 455                 460                 
Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn
465                 470                 475                 480 
Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr
                485                 490                 495     
Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile
            500                 505                 510         
Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val
        515                 520                 525             
Ser Arg Asp Lys Leu Ile Gln Asp Ser Arg Arg Glu Thr Lys Asn Val
    530                 535                 540                 
Ala Ser Gly Gly Gly Gly Val Gly Asp Gly Val Gln Glu Pro Thr Thr
545                 550                 555                 560 
Gly Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu
                565                 570                 575     
Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro Ala Ser Pro Gln
            580                 585                 590         
Lys Gly His Ala Val Asn Leu Leu Asp Val Pro Val Pro Val Ala Arg
        595                 600                 605             
Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val Ile Glu Arg Leu
    610                 615                 620                 
Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile Gln Asp Ser Val
625                 630                 635                 640 
Pro Lys Ala Val Met His Phe Leu Val Asn His Val Lys Asp Thr Leu
                645                 650                 655     
Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp
            660                 665                 670         
Leu Leu Thr Glu Ser Glu Asp Met Ala Gln Arg Arg Lys Glu Ala Ala
        675                 680                 685             
Asp Met Leu Lys Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile
    690                 695                 700                 
Arg Glu Thr His Leu Trp
705                 710 


<210> 7697
<211> 699
<212> PRT
<213> Homo sapiens

<400> 7697
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn
 1               5                  10                  15      
Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly
            20                  25                  30          
Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg
        35                  40                  45              
Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile
    50                  55                  60                  
Leu Gln Leu Val His Val Thr Gln Glu Asp Lys Arg Lys Thr Thr Gly
65                  70                  75                  80  
Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr
                85                  90                  95      
Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu
            100                 105                 110         
Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu
        115                 120                 125             
Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu
    130                 135                 140                 
Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys
145                 150                 155                 160 
Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn
                165                 170                 175     
Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala
            180                 185                 190         
Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Cys
        195                 200                 205             
Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr
    210                 215                 220                 
Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly
225                 230                 235                 240 
Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys
                245                 250                 255     
Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys
            260                 265                 270         
Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr
        275                 280                 285             
Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu
    290                 295                 300                 
Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn
305                 310                 315                 320 
Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu
                325                 330                 335     
Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala
            340                 345                 350         
Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr
        355                 360                 365             
Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu
    370                 375                 380                 
Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr
385                 390                 395                 400 
Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu
                405                 410                 415     
Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val
            420                 425                 430         
Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn
        435                 440                 445             
Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile
    450                 455                 460                 
Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn
465                 470                 475                 480 
Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr
                485                 490                 495     
Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile
            500                 505                 510         
Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val
        515                 520                 525             
Ser Arg Asp Lys Val Ala Ser Gly Gly Gly Gly Val Gly Asp Gly Val
    530                 535                 540                 
Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met Leu Lys Thr Ser Lys
545                 550                 555                 560 
Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile Met
                565                 570                 575     
Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn Leu Leu Asp Val Pro
            580                 585                 590         
Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu
        595                 600                 605             
Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn
    610                 615                 620                 
Ile Gln Asp Ser Val Pro Lys Ala Val Met His Phe Leu Val Asn His
625                 630                 635                 640 
Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser
                645                 650                 655     
Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu Asp Met Ala Gln Arg
            660                 665                 670         
Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu Gln Gly Ala Ser Gln
        675                 680                 685             
Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp
    690                 695                 


<210> 7698
<211> 560
<212> PRT
<213> Homo sapiens

<400> 7698
Met Ser Glu Glu Thr Val Pro Glu Ala Ala Ser Pro Pro Pro Pro Gln
 1               5                  10                  15      
Gly Gln Pro Tyr Phe Asp Arg Phe Ser Glu Asp Asp Pro Glu Tyr Met
            20                  25                  30          
Arg Leu Arg Asn Arg Ala Ala Asp Leu Arg Gln Asp Phe Asn Leu Met
        35                  40                  45              
Glu Gln Lys Lys Arg Val Thr Met Ile Leu Gln Ser Pro Ser Phe Arg
    50                  55                  60                  
Glu Glu Leu Glu Gly Leu Ile Gln Glu Gln Met Lys Lys Gly Asn Asn
65                  70                  75                  80  
Ser Ser Asn Ile Trp Ala Leu Arg Gln Ile Ala Asp Phe Met Ala Ser
                85                  90                  95      
Thr Ser His Ala Val Phe Pro Thr Ser Ser Met Asn Val Ser Met Met
            100                 105                 110         
Thr Pro Ile Asn Asp Leu His Thr Ala Asp Ser Leu Asn Leu Ala Lys
        115                 120                 125             
Gly Glu Arg Leu Met Arg Cys Lys Ile Ser Ser Val Tyr Arg Leu Leu
    130                 135                 140                 
Asp Leu Tyr Gly Trp Ala Gln Leu Ser Asp Thr Tyr Val Thr Leu Arg
145                 150                 155                 160 
Val Ser Lys Glu Gln Asp His Phe Leu Ile Ser Pro Lys Gly Val Ser
                165                 170                 175     
Cys Ser Glu Val Thr Ala Ser Ser Leu Ile Lys Val Asn Ile Leu Gly
            180                 185                 190         
Glu Val Val Glu Lys Gly Ser Ser Cys Phe Pro Val Asp Thr Thr Gly
        195                 200                 205             
Phe Cys Leu His Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Arg Cys
    210                 215                 220                 
Ile Ile His Leu His Thr Pro Ala Thr Ala Ala Val Ser Ala Met Lys
225                 230                 235                 240 
Trp Gly Leu Leu Pro Val Ser His Asn Ala Leu Leu Val Gly Asp Met
                245                 250                 255     
Ala Tyr Tyr Asp Phe Asn Gly Glu Met Glu Gln Glu Ala Asp Arg Ile
            260                 265                 270         
Asn Leu Gln Lys Cys Leu Gly Pro Thr Cys Lys Ile Leu Val Leu Arg
        275                 280                 285             
Asn His Gly Val Val Ala Leu Gly Asp Thr Val Glu Glu Ala Phe Tyr
    290                 295                 300                 
Lys Ile Phe His Leu Gln Ala Ala Cys Glu Ile Gln Val Ser Ala Leu
305                 310                 315                 320 
Ser Ser Ala Gly Gly Val Glu Asn Leu Ile Leu Leu Glu Gln Glu Lys
                325                 330                 335     
His Arg Pro His Glu Val Gly Ser Val Gln Trp Ala Gly Ser Thr Phe
            340                 345                 350         
Gly Pro Met Gln Lys Ser Arg Leu Gly Glu His Glu Phe Glu Ala Leu
        355                 360                 365             
Met Arg Met Leu Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Thr Tyr Arg
    370                 375                 380                 
His Pro Phe Val Gln Glu Lys Thr Lys His Lys Ser Glu Val Glu Ile
385                 390                 395                 400 
Pro Ala Thr Val Thr Ala Phe Val Phe Glu Glu Asp Gly Ala Pro Val
                405                 410                 415     
Pro Ala Leu Arg Gln His Ala Gln Lys Gln Gln Lys Glu Lys Thr Arg
            420                 425                 430         
Trp Leu Asn Thr Pro Asn Thr Tyr Leu Arg Val Asn Val Ala Asp Glu
        435                 440                 445             
Val Gln Arg Ser Met Gly Ser Pro Arg Pro Lys Thr Thr Trp Met Lys
    450                 455                 460                 
Ala Asp Glu Val Glu Lys Ser Ser Ser Gly Met Pro Ile Arg Ile Glu
465                 470                 475                 480 
Asn Pro Asn Gln Phe Val Pro Leu Tyr Thr Asp Pro Gln Glu Val Leu
                485                 490                 495     
Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Arg Gln Asp Val Lys Ser
            500                 505                 510         
Ala Gly Pro Gln Ser Gln Leu Leu Ala Ser Val Ile Ala Glu Lys Ser
        515                 520                 525             
Arg Ser Pro Val Glu Gln Arg Leu Pro Leu Thr Gly Gly Glu Thr Cys
    530                 535                 540                 
Leu Pro Cys Leu Arg Gly Leu Val Pro Gly Ala Gly Leu Gln Asp Pro
545                 550                 555                 560 


<210> 7699
<211> 421
<212> PRT
<213> Homo sapiens

<400> 7699
Met Ser Glu Glu Thr Val Pro Glu Ala Ala Ser Pro Pro Pro Pro Gln
 1               5                  10                  15      
Gly Gln Pro Tyr Phe Asp Arg Phe Ser Glu Asp Asp Pro Glu Tyr Met
            20                  25                  30          
Arg Leu Arg Asn Arg Ala Ala Asp Leu Arg Gln Asp Phe Asn Leu Met
        35                  40                  45              
Glu Gln Lys Lys Arg Val Thr Met Ile Leu Gln Ser Pro Ser Phe Arg
    50                  55                  60                  
Glu Glu Leu Glu Gly Leu Ile Gln Glu Gln Met Lys Lys Gly Asn Asn
65                  70                  75                  80  
Ser Ser Asn Ile Trp Ala Leu Arg Gln Ile Ala Asp Phe Met Ala Ser
                85                  90                  95      
Thr Ser His Ala Val Phe Pro Thr Ser Ser Met Asn Val Ser Met Met
            100                 105                 110         
Thr Pro Ile Asn Asp Leu His Thr Ala Asp Ser Leu Asn Leu Ala Lys
        115                 120                 125             
Gly Glu Arg Leu Met Arg Cys Lys Ile Ser Ser Val Tyr Arg Leu Leu
    130                 135                 140                 
Asp Leu Tyr Gly Trp Ala Gln Leu Ser Asp Thr Tyr Val Thr Leu Arg
145                 150                 155                 160 
Val Ser Lys Glu Gln Asp His Phe Leu Ile Ser Pro Lys Gly Val Ser
                165                 170                 175     
Cys Ser Glu Val Thr Ala Ser Ser Leu Val Thr His Ser Ser Ser Pro
            180                 185                 190         
Leu Ser Thr Gln Ile Arg Glu Gln Asn Arg Gln Asp Val Lys Ser Ala
        195                 200                 205             
Gly Pro Gln Ser Gln Leu Leu Ala Ser Val Ile Ala Glu Lys Ser Arg
    210                 215                 220                 
Ser Pro Ser Thr Glu Ser Gln Leu Met Ser Lys Gly Asp Glu Asp Thr
225                 230                 235                 240 
Lys Asp Asp Ser Glu Glu Thr Val Pro Asn Pro Phe Ser Gln Leu Thr
                245                 250                 255     
Asp Gln Glu Leu Glu Glu Tyr Lys Lys Glu Val Glu Arg Lys Lys Leu
            260                 265                 270         
Glu Leu Asp Gly Glu Lys Glu Thr Ala Pro Glu Glu Pro Gly Ser Pro
        275                 280                 285             
Ala Lys Ser Ala Pro Ala Ser Pro Val Gln Ser Pro Ala Lys Glu Ala
    290                 295                 300                 
Glu Thr Lys Ser Pro Leu Val Ser Pro Ser Lys Ser Leu Glu Glu Gly
305                 310                 315                 320 
Thr Lys Lys Thr Glu Thr Ser Lys Ala Ala Thr Thr Glu Pro Glu Thr
                325                 330                 335     
Thr Gln Pro Glu Gly Val Val Val Asn Gly Arg Glu Glu Glu Gln Thr
            340                 345                 350         
Ala Glu Glu Ile Leu Ser Lys Gly Leu Ser Gln Met Thr Thr Ser Ala
        355                 360                 365             
Asp Thr Asp Val Asp Thr Ser Lys Asp Lys Thr Glu Ser Val Thr Ser
    370                 375                 380                 
Gly Pro Met Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys
385                 390                 395                 400 
Lys Lys Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys
                405                 410                 415     
Glu Lys Val Glu Ser
            420     


<210> 7700
<211> 643
<212> PRT
<213> Homo sapiens

<400> 7700
Met Ser Glu Glu Thr Val Pro Glu Ala Ala Ser Pro Pro Pro Pro Gln
 1               5                  10                  15      
Gly Gln Pro Tyr Phe Asp Arg Phe Ser Glu Asp Asp Pro Glu Tyr Met
            20                  25                  30          
Arg Leu Arg Asn Arg Ala Ala Asp Leu Arg Gln Asp Phe Asn Leu Met
        35                  40                  45              
Glu Gln Lys Lys Arg Val Thr Met Ile Leu Gln Ser Pro Ser Phe Arg
    50                  55                  60                  
Glu Glu Leu Glu Gly Leu Ile Gln Glu Gln Met Lys Lys Gly Asn Asn
65                  70                  75                  80  
Ser Ser Asn Ile Trp Ala Leu Arg Gln Ile Ala Asp Phe Met Ala Ser
                85                  90                  95      
Thr Ser His Ala Val Phe Pro Thr Ser Ser Met Asn Val Ser Met Met
            100                 105                 110         
Thr Pro Ile Asn Asp Leu His Thr Ala Asp Ser Leu Asn Leu Ala Lys
        115                 120                 125             
Gly Glu Arg Leu Met Arg Cys Lys Ile Ser Ser Val Tyr Arg Leu Leu
    130                 135                 140                 
Asp Leu Tyr Gly Trp Ala Gln Leu Ser Asp Thr Tyr Val Thr Leu Arg
145                 150                 155                 160 
Val Ser Lys Glu Gln Asp His Phe Leu Ile Ser Pro Lys Gly Val Ser
                165                 170                 175     
Cys Ser Glu Val Thr Ala Ser Ser Leu Ile Lys Val Asn Ile Leu Gly
            180                 185                 190         
Glu Val Val Glu Lys Gly Ser Ser Cys Phe Pro Val Asp Thr Thr Gly
        195                 200                 205             
Phe Cys Leu His Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Arg Cys
    210                 215                 220                 
Ile Ile His Leu His Thr Pro Ala Thr Ala Ala Val Ser Ala Met Lys
225                 230                 235                 240 
Trp Gly Leu Leu Pro Val Ser His Asn Ala Leu Leu Val Gly Asp Met
                245                 250                 255     
Ala Tyr Tyr Asp Phe Asn Gly Glu Met Glu Gln Glu Ala Asp Arg Ile
            260                 265                 270         
Asn Leu Gln Lys Cys Leu Gly Pro Thr Cys Lys Ile Leu Val Leu Arg
        275                 280                 285             
Asn His Gly Val Val Ala Leu Gly Asp Thr Val Glu Glu Ala Phe Tyr
    290                 295                 300                 
Lys Ile Phe His Leu Gln Ala Ala Cys Glu Ile Gln Val Ser Ala Leu
305                 310                 315                 320 
Ser Ser Ala Gly Gly Val Glu Asn Leu Ile Leu Leu Glu Gln Glu Lys
                325                 330                 335     
His Arg Pro His Glu Val Gly Ser Val Gln Trp Ala Gly Ser Thr Phe
            340                 345                 350         
Gly Pro Met Gln Lys Ser Arg Leu Gly Glu His Glu Phe Glu Ala Leu
        355                 360                 365             
Met Arg Met Leu Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Thr Tyr Arg
    370                 375                 380                 
His Pro Phe Val Gln Glu Lys Thr Lys His Lys Ser Glu Val Glu Ile
385                 390                 395                 400 
Pro Ala Thr Val Thr Ala Phe Val Phe Glu Glu Asp Gly Ala Pro Val
                405                 410                 415     
Pro Ala Leu Arg Gln His Ala Gln Lys Gln Gln Lys Glu Lys Thr Arg
            420                 425                 430         
Trp Leu Asn Thr Pro Asn Thr Tyr Leu Arg Val Asn Val Ala Asp Glu
        435                 440                 445             
Val Gln Arg Ser Met Gly Ser Pro Arg Pro Lys Thr Thr Trp Met Lys
    450                 455                 460                 
Ala Asp Glu Val Glu Lys Ser Ser Ser Gly Met Pro Ile Arg Ile Glu
465                 470                 475                 480 
Asn Pro Asn Gln Phe Val Pro Leu Tyr Thr Asp Pro Gln Glu Val Leu
                485                 490                 495     
Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Arg Gln Asp Val Lys Ser
            500                 505                 510         
Ala Gly Pro Gln Ser Gln Leu Leu Ala Ser Val Ile Ala Glu Lys Ser
        515                 520                 525             
Arg Ser Pro Ser Thr Glu Ser Gln Leu Met Ser Lys Gly Asp Glu Asp
    530                 535                 540                 
Thr Lys Asp Asp Ser Glu Glu Thr Val Pro Asn Pro Phe Ser Gln Leu
545                 550                 555                 560 
Thr Asp Gln Glu Leu Glu Glu Tyr Lys Lys Glu Val Glu Arg Lys Lys
                565                 570                 575     
Leu Glu Leu Asp Glu Thr Gly Gln Glu Arg Glu Pro Gly Ser Gly Pro
            580                 585                 590         
Ala Val Cys Glu Phe Phe Ser Val Ala Leu His Ile Trp Ser Asn Ile
        595                 600                 605             
Leu Glu Arg Lys Lys Leu Pro Gln Lys Ser Leu Ala His Leu Gln Ser
    610                 615                 620                 
Leu His Leu Leu Leu Gln Cys Arg Ala Gln Arg Arg Arg Gln Arg Gln
625                 630                 635                 640 
Arg Ala Leu
            


<210> 7701
<211> 254
<212> PRT
<213> Homo sapiens

<400> 7701
Met Ser Glu Glu Thr Val Pro Glu Ala Ala Ser Pro Pro Pro Pro Gln
 1               5                  10                  15      
Gly Gln Pro Tyr Phe Asp Arg Phe Ser Glu Asp Asp Pro Glu Tyr Met
            20                  25                  30          
Arg Leu Arg Asn Arg Ala Ala Asp Leu Arg Gln Asp Phe Asn Leu Met
        35                  40                  45              
Glu Gln Lys Lys Arg Val Thr Met Ile Leu Gln Ser Pro Ser Phe Arg
    50                  55                  60                  
Glu Glu Leu Glu Gly Leu Ile Gln Glu Gln Met Lys Lys Gly Asn Asn
65                  70                  75                  80  
Ser Ser Asn Ile Trp Ala Leu Arg Gln Ile Ala Asp Phe Met Ala Ser
                85                  90                  95      
Thr Ser His Ala Val Phe Pro Thr Ser Ser Met Asn Val Ser Met Met
            100                 105                 110         
Thr Pro Ile Asn Asp Leu His Thr Ala Asp Ser Leu Asn Leu Ala Lys
        115                 120                 125             
Gly Glu Arg Leu Met Arg Cys Lys Ile Ser Ser Val Tyr Arg Leu Leu
    130                 135                 140                 
Asp Leu Tyr Gly Trp Ala Gln Leu Ser Asp Thr Tyr Val Thr Leu Arg
145                 150                 155                 160 
Val Ser Lys Glu Gln Asp His Phe Leu Ile Ser Pro Lys Gly Val Ser
                165                 170                 175     
Cys Ser Glu Val Thr Ala Ser Ser Leu Ile Lys Glu Val Leu Glu Met
            180                 185                 190         
Arg Asn Lys Ile Arg Glu Gln Asn Arg Gln Asp Val Lys Ser Ala Gly
        195                 200                 205             
Pro Gln Ser Gln Leu Leu Ala Ser Val Ile Ala Glu Lys Ser Arg Ser
    210                 215                 220                 
Pro Val Glu Gln Arg Leu Pro Leu Thr Gly Gly Glu Thr Cys Leu Pro
225                 230                 235                 240 
Cys Leu Arg Gly Leu Val Pro Gly Ala Gly Leu Gln Asp Pro
                245                 250                 


<210> 7702
<211> 726
<212> PRT
<213> Homo sapiens

<400> 7702
Met Ser Glu Glu Thr Val Pro Glu Ala Ala Ser Pro Pro Pro Pro Gln
 1               5                  10                  15      
Gly Gln Pro Tyr Phe Asp Arg Phe Ser Glu Asp Asp Pro Glu Tyr Met
            20                  25                  30          
Arg Leu Arg Asn Arg Ala Ala Asp Leu Arg Gln Asp Phe Asn Leu Met
        35                  40                  45              
Glu Gln Lys Lys Arg Val Thr Met Ile Leu Gln Ser Pro Ser Phe Arg
    50                  55                  60                  
Glu Glu Leu Glu Gly Leu Ile Gln Glu Gln Met Lys Lys Gly Asn Asn
65                  70                  75                  80  
Ser Ser Asn Ile Trp Ala Leu Arg Gln Ile Ala Asp Phe Met Ala Ser
                85                  90                  95      
Thr Ser His Ala Val Phe Pro Thr Ser Ser Met Asn Val Ser Met Met
            100                 105                 110         
Thr Pro Ile Asn Asp Leu His Thr Ala Asp Ser Leu Asn Leu Ala Lys
        115                 120                 125             
Gly Glu Arg Leu Met Arg Cys Lys Ile Ser Ser Val Tyr Arg Leu Leu
    130                 135                 140                 
Asp Leu Tyr Gly Trp Ala Gln Leu Ser Asp Thr Tyr Val Thr Leu Arg
145                 150                 155                 160 
Val Ser Lys Glu Gln Asp His Phe Leu Ile Ser Pro Lys Gly Val Ser
                165                 170                 175     
Cys Ser Glu Val Thr Ala Ser Ser Leu Ile Lys Val Asn Ile Leu Gly
            180                 185                 190         
Glu Val Val Glu Lys Gly Ser Ser Cys Phe Pro Val Asp Thr Thr Gly
        195                 200                 205             
Phe Cys Leu His Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Arg Cys
    210                 215                 220                 
Ile Ile His Leu His Thr Pro Ala Thr Ala Ala Val Ser Ala Met Lys
225                 230                 235                 240 
Trp Gly Leu Leu Pro Val Ser His Asn Ala Leu Leu Val Gly Asp Met
                245                 250                 255     
Ala Tyr Tyr Asp Phe Asn Gly Glu Met Glu Gln Glu Ala Asp Arg Ile
            260                 265                 270         
Asn Leu Gln Lys Cys Leu Gly Pro Thr Cys Lys Ile Leu Val Leu Arg
        275                 280                 285             
Asn His Gly Val Val Ala Leu Gly Asp Thr Val Glu Glu Ala Phe Tyr
    290                 295                 300                 
Lys Ile Phe His Leu Gln Ala Ala Cys Glu Ile Gln Val Ser Ala Leu
305                 310                 315                 320 
Ser Ser Ala Gly Gly Val Glu Asn Leu Ile Leu Leu Glu Gln Glu Lys
                325                 330                 335     
His Arg Pro His Glu Val Gly Ser Val Gln Trp Ala Gly Ser Thr Phe
            340                 345                 350         
Gly Pro Met Gln Lys Ser Arg Leu Gly Glu His Glu Phe Glu Ala Leu
        355                 360                 365             
Met Arg Met Leu Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Thr Tyr Arg
    370                 375                 380                 
His Pro Phe Val Gln Glu Lys Thr Lys His Lys Ser Glu Val Glu Ile
385                 390                 395                 400 
Pro Ala Thr Val Thr Ala Phe Val Phe Glu Glu Asp Gly Ala Pro Val
                405                 410                 415     
Pro Ala Leu Arg Gln His Ala Gln Lys Gln Gln Lys Glu Lys Thr Arg
            420                 425                 430         
Trp Leu Asn Thr Pro Asn Thr Tyr Leu Arg Val Asn Val Ala Asp Glu
        435                 440                 445             
Val Gln Arg Ser Met Gly Ser Pro Arg Pro Lys Thr Thr Trp Met Lys
    450                 455                 460                 
Ala Asp Glu Val Glu Lys Ser Ser Ser Gly Met Pro Ile Arg Ile Glu
465                 470                 475                 480 
Asn Pro Asn Gln Phe Val Pro Leu Tyr Thr Asp Pro Gln Glu Val Leu
                485                 490                 495     
Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Arg Gln Asp Val Lys Ser
            500                 505                 510         
Ala Gly Pro Gln Ser Gln Leu Leu Ala Ser Val Ile Ala Glu Lys Ser
        515                 520                 525             
Arg Ser Pro Ser Thr Glu Ser Gln Leu Met Ser Lys Gly Asp Glu Asp
    530                 535                 540                 
Thr Lys Asp Asp Ser Glu Glu Thr Val Pro Asn Pro Phe Ser Gln Leu
545                 550                 555                 560 
Thr Asp Gln Glu Leu Glu Glu Tyr Lys Lys Glu Val Glu Arg Lys Lys
                565                 570                 575     
Leu Glu Leu Asp Gly Glu Lys Glu Thr Ala Pro Glu Glu Pro Gly Ser
            580                 585                 590         
Pro Ala Lys Ser Ala Pro Ala Ser Pro Val Gln Ser Pro Ala Lys Glu
        595                 600                 605             
Ala Glu Thr Lys Ser Pro Leu Val Ser Pro Ser Lys Ser Leu Glu Glu
    610                 615                 620                 
Gly Thr Lys Lys Thr Glu Thr Ser Lys Ala Ala Thr Thr Glu Pro Glu
625                 630                 635                 640 
Thr Thr Gln Pro Glu Gly Val Val Val Asn Gly Arg Glu Glu Glu Gln
                645                 650                 655     
Thr Ala Glu Glu Ile Leu Ser Lys Gly Leu Ser Gln Met Thr Thr Ser
            660                 665                 670         
Ala Asp Thr Asp Val Asp Thr Ser Lys Asp Lys Thr Glu Ser Val Thr
        675                 680                 685             
Ser Gly Pro Met Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys
    690                 695                 700                 
Lys Lys Lys Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys
705                 710                 715                 720 
Lys Glu Lys Val Glu Ser
                725     


<210> 7703
<211> 518
<212> PRT
<213> Homo sapiens

<400> 7703
Met Glu Val Leu Gln Val Ser Phe Arg Ile Val Ile Ser Gly Glu Lys
 1               5                  10                  15      
Glu Gly Thr Val Gly Gly Val Cys Gly Pro Arg Arg Ser Ser Ser Ala
            20                  25                  30          
Ser Pro Gln Glu Gln Asp Gln Asp Arg Arg Lys Asp Trp Gly His Val
        35                  40                  45              
Glu Leu Leu Glu Val Leu Gln Ala Arg Val Arg Gln Leu Gln Ala Gly
    50                  55                  60                  
Ser Val Ser Glu Val Val Val Asn Arg Val Asp Val Ala Trp Leu Pro
65                  70                  75                  80  
Glu Cys Gly Ser Gly Gly Gly Ser Leu Gln Pro Pro Arg Lys Val Gln
                85                  90                  95      
Met Gly Val Lys Asp Ala Thr Pro Val Pro Cys Gly Arg Trp Ala Lys
            100                 105                 110         
Arg Leu Glu Lys Asp Lys Arg Thr Gln Gln Met Arg Met Gln Arg Leu
        115                 120                 125             
Lys Ala Lys Leu Gln Met Pro Phe Gln Ser Gly Glu Phe Lys Ala Leu
    130                 135                 140                 
Thr Arg Arg Leu Gln Glu Ala Pro Gly Lys Leu Ser Leu Asp Val Glu
145                 150                 155                 160 
Gln Ala Pro Ser Ala Gln His Ser Gln Ala Gln Leu Ser Gly Gln Gln
                165                 170                 175     
Gln Arg Leu Leu Ala Phe Phe Lys Cys Cys Leu Leu Thr Asp Gln Leu
            180                 185                 190         
Pro Leu Ala His His Leu Leu Val Val His His Gly Gln Arg Gln Lys
        195                 200                 205             
Arg Lys Leu Leu Thr Leu Asp Met Tyr Asn Ala Val Met Leu Gly Trp
    210                 215                 220                 
Ala Arg Gln Gly Ala Phe Lys Glu Leu Val Tyr Val Leu Phe Met Val
225                 230                 235                 240 
Lys Asp Ala Gly Leu Thr Pro Asp Leu Leu Ser Tyr Ala Ala Ala Leu
                245                 250                 255     
Gln Cys Met Gly Arg Gln Asp Gln Asp Ala Gly Thr Ile Glu Arg Cys
            260                 265                 270         
Leu Glu Gln Met Ser Gln Glu Gly Leu Lys Leu Gln Ala Leu Phe Thr
        275                 280                 285             
Ala Val Pro Leu Ser Glu Glu Asp Arg Ala Thr Val Leu Lys Ala Val
    290                 295                 300                 
His Lys Val Lys Pro Thr Phe Ser Leu Pro Leu Gln Leu Pro Pro Pro
305                 310                 315                 320 
Val Asn Thr Ser Lys Leu Leu Arg Asp Val Tyr Ala Lys Asp Gly Arg
                325                 330                 335     
Val Ser Tyr Pro Lys Leu His Leu Pro Leu Lys Thr Leu Gln Cys Leu
            340                 345                 350         
Phe Glu Lys Gln Leu His Val Glu Leu Ala Ser Arg Met Cys Val Val
        355                 360                 365             
Ser Val Glu Lys Pro Thr Leu Pro Ser Lys Glu Val Thr His Ala Arg
    370                 375                 380                 
Lys Thr Leu Lys Thr Leu Arg Asp Gln Trp Glu Lys Ala Leu Cys Arg
385                 390                 395                 400 
Glu Leu Arg Glu Thr Lys Asn Arg Leu Glu Arg Gln Val Lys Gln Ile
                405                 410                 415     
Gly Gly Gly Ile Gln Ser Ile Thr Tyr Thr His Asn Gly Asp Ile Ser
            420                 425                 430         
Arg Lys Pro Asn Thr Arg Lys Gln Lys Asn Gly Phe Pro Pro Asn Phe
        435                 440                 445             
Ile His Ser Leu Asp Ser Ser His Met Met Leu Thr Ala Leu His Cys
    450                 455                 460                 
Tyr Arg Lys Gly Leu Thr Phe Val Ser Val His Asp Cys Tyr Trp Thr
465                 470                 475                 480 
His Ala Ala Asp Val Ser Cys His Glu Pro Gly Val Pro Gly Ala Val
                485                 490                 495     
Cys Pro Leu Ala Gln Arg Ala His Pro Ala Gly Pro Val Gln Val Pro
            500                 505                 510         
Gly Gln Ala Val Leu Leu
        515             


<210> 7704
<211> 825
<212> PRT
<213> Homo sapiens

<400> 7704
Met Ala Ala Gly Lys Phe Ala Ser Leu Pro Arg Asn Met Pro Val Asn
 1               5                  10                  15      
His Gln Phe Pro Leu Ala Ser Ser Met Asp Leu Leu Ser Ser Arg Ser
            20                  25                  30          
Pro Leu Ala Glu His Arg Pro Asp Ala Tyr Gln Asp Val Ser Ile His
        35                  40                  45              
Gly Thr Leu Pro Arg Lys Lys Lys Gly Pro Pro Pro Ile Arg Ser Cys
    50                  55                  60                  
Asp Asp Phe Ser His Met Gly Thr Leu Pro His Ser Lys Ser Pro Arg
65                  70                  75                  80  
Gln Asn Ser Pro Val Thr Gln Asp Gly Ile Gln Glu Ser Pro Trp Gln
                85                  90                  95      
Asp Arg His Gly Glu Thr Phe Thr Phe Arg Asp Pro His Leu Leu Asp
            100                 105                 110         
Pro Thr Val Glu Tyr Val Lys Phe Ser Lys Glu Arg His Ile Met Asp
        115                 120                 125             
Arg Thr Pro Glu Lys Leu Lys Lys Glu Leu Glu Glu Glu Leu Leu Leu
    130                 135                 140                 
Ser Ser Glu Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro
145                 150                 155                 160 
Arg Gln Val Ser Glu Asn Leu Val Gln Arg Asp Gly Asp Phe Leu Val
                165                 170                 175     
Arg Asp Ser Leu Ser Ser Pro Gly Asn Phe Val Leu Thr Cys Gln Trp
            180                 185                 190         
Lys Asn Leu Ala Gln His Phe Lys Ile Asn Arg Thr Val Leu Arg Leu
        195                 200                 205             
Ser Glu Ala Tyr Ser Arg Val Gln Tyr Gln Phe Glu Met Glu Ser Phe
    210                 215                 220                 
Asp Ser Ile Pro Gly Leu Val Arg Cys Tyr Val Gly Asn Arg Arg Pro
225                 230                 235                 240 
Ile Ser Gln Gln Ser Gly Ala Ile Ile Phe Gln Pro Ile Asn Arg Thr
                245                 250                 255     
Val Pro Leu Arg Cys Leu Glu Glu His Tyr Gly Thr Ser Pro Gly Gln
            260                 265                 270         
Ala Arg Glu Gly Ser Leu Thr Lys Gly Arg Pro Asp Val Ala Lys Arg
        275                 280                 285             
Leu Ser Leu Thr Met Gly Gly Val Gln Ala Arg Glu Gln Asn Leu Pro
    290                 295                 300                 
Arg Gly Asn Leu Leu Arg Asn Lys Glu Lys Ser Gly Ser Gln Pro Ala
305                 310                 315                 320 
Cys Leu Asp His Met Gln Asp Arg Arg Ala Leu Ser Leu Lys Ala His
                325                 330                 335     
Gln Ser Glu Ser Tyr Leu Pro Ile Gly Cys Lys Leu Pro Pro Gln Ser
            340                 345                 350         
Ser Gly Val Asp Thr Ser Pro Cys Pro Asn Ser Pro Val Phe Arg Thr
        355                 360                 365             
Gly Ser Glu Pro Ala Leu Ser Pro Ala Val Val Arg Arg Val Ser Ser
    370                 375                 380                 
Asp Ala Arg Ala Gly Glu Ala Leu Arg Gly Ser Asp Ser Gln Leu Cys
385                 390                 395                 400 
Pro Lys Pro Pro Pro Lys Pro Cys Lys Val Pro Phe Leu Lys Val Pro
                405                 410                 415     
Ser Ser Pro Ser Ala Trp Leu Asn Ser Glu Ala Asn Tyr Cys Glu Leu
            420                 425                 430         
Asn Pro Ala Phe Ala Thr Gly Cys Gly Arg Gly Ala Lys Leu Pro Ser
        435                 440                 445             
Cys Ala Gln Gly Ser His Thr Glu Leu Leu Thr Ala Lys Gln Asn Glu
    450                 455                 460                 
Ala Pro Gly Pro Arg Asn Ser Gly Val Asn Tyr Leu Ile Leu Asp Asp
465                 470                 475                 480 
Asp Asp Arg Glu Arg Pro Trp Glu Pro Ala Ala Ala Gln Met Glu Lys
                485                 490                 495     
Gly Gln Trp Asp Lys Gly Glu Phe Val Thr Pro Leu Leu Glu Thr Val
            500                 505                 510         
Ser Ser Phe Arg Pro Asn Glu Phe Glu Ser Lys Phe Leu Pro Pro Glu
        515                 520                 525             
Asn Lys Pro Leu Glu Thr Ala Met Leu Lys Arg Ala Lys Glu Leu Phe
    530                 535                 540                 
Thr Asn Asn Asp Pro Lys Val Ile Ala Gln His Val Leu Ser Met Asp
545                 550                 555                 560 
Cys Arg Val Ala Arg Ile Leu Gly Val Ser Glu Glu Met Arg Arg Asn
                565                 570                 575     
Met Gly Val Ser Ser Gly Leu Glu Leu Ile Thr Leu Pro His Gly His
            580                 585                 590         
Gln Leu Arg Leu Asp Ile Ile Glu Arg His Asn Thr Met Ala Ile Gly
        595                 600                 605             
Ile Ala Val Asp Ile Leu Gly Cys Thr Gly Thr Leu Glu Asp Arg Ala
    610                 615                 620                 
Ala Thr Leu Ser Lys Ile Ile Gln Val Ala Val Glu Leu Lys Asp Ser
625                 630                 635                 640 
Met Gly Asp Leu Tyr Ser Phe Ser Ala Leu Met Lys Ala Leu Glu Met
                645                 650                 655     
Pro Gln Ile Thr Arg Leu Glu Lys Thr Trp Thr Ala Leu Arg His Gln
            660                 665                 670         
Tyr Thr Gln Thr Ala Ile Leu Tyr Glu Lys Gln Leu Lys Pro Phe Ser
        675                 680                 685             
Lys Leu Leu His Glu Gly Arg Glu Ser Thr Cys Val Pro Pro Asn Asn
    690                 695                 700                 
Val Ser Val Pro Leu Leu Met Pro Leu Val Thr Leu Met Glu Arg Gln
705                 710                 715                 720 
Ala Val Thr Phe Glu Gly Thr Asp Met Trp Glu Lys Asn Asp Gln Ser
                725                 730                 735     
Cys Glu Ile Met Leu Asn His Leu Ala Thr Ala Arg Phe Met Ala Glu
            740                 745                 750         
Ala Ala Asp Ser Tyr Arg Met Asn Ala Glu Arg Ile Leu Ala Gly Phe
        755                 760                 765             
Gln Pro Asp Glu Glu Met Asn Glu Ile Cys Lys Thr Glu Phe Gln Met
    770                 775                 780                 
Arg Leu Leu Trp Gly Ser Lys Gly Ala Gln Val Asn Gln Thr Glu Arg
785                 790                 795                 800 
Tyr Glu Lys Phe Asn Gln Ile Leu Thr Ala Leu Ser Arg Lys Leu Glu
                805                 810                 815     
Pro Pro Pro Val Lys Gln Ala Glu Leu
            820                 825 


<210> 7705
<211> 579
<212> PRT
<213> Homo sapiens

<400> 7705
Met Asp Leu Ile Leu Asp Gly Pro Ala Val Leu Ser Phe Ser Thr Gln
 1               5                  10                  15      
Arg Ile Pro Pro Ser Val Glu Lys Leu Leu Glu His Thr Gly Thr Ser
            20                  25                  30          
Lys Asp Ser Ile Asp His Phe Ile Phe His Gln Ala Asn Arg Met Ile
        35                  40                  45              
Asn Glu Thr Ile Arg Lys Lys Leu Gly Leu Pro Ala Glu Lys Val Pro
    50                  55                  60                  
Ser Thr Leu His Asp Phe Gly Asn Thr Ser Gly Ala Ser Leu Pro Val
65                  70                  75                  80  
Thr Val Thr Ala Arg Leu His Glu Gln Leu Asp Gly Ala Arg Ala Arg
                85                  90                  95      
Leu Leu Leu Asn Gly Arg Ala Met Ser Thr Pro Asp Pro Phe Ser Leu
            100                 105                 110         
Ala Gly Lys Arg Ile Leu Val Thr Gly Ala Ser Ser Gly Ile Gly Arg
        115                 120                 125             
Gln Ile Ala Ile Ser Cys Ala Glu Gln Gly Ala Glu Leu Val Ile Thr
    130                 135                 140                 
Gly Arg Asn Pro Asp Arg Leu Ala Ser Thr Tyr Glu Ala Leu Gln Gly
145                 150                 155                 160 
Asp Gly His Gln Ser Ile Val Ala Asp Leu Ser Asn Ala Ala Asp Leu
                165                 170                 175     
Asp Ser Leu Val Thr Ala Ala Gly Val Leu Asn Gly Val Val His Ala
            180                 185                 190         
Ala Gly Ile Ser Lys Leu Val Pro Phe Arg Met Val Asn Glu Thr His
        195                 200                 205             
Leu Asp Glu Ile Phe Ala Ser Asn Thr Phe Ala Pro Ile Leu Leu Thr
    210                 215                 220                 
Lys Gly Leu Leu Ala Lys Lys Arg Ile Ser Pro Gln Gly Ser Ile Val
225                 230                 235                 240 
Phe Val Thr Ser Val Ala Ser His Ile Gly Pro Met Ala Ser Ala Ala
                245                 250                 255     
Tyr Ala Ala Ser Lys Ala Ala Leu Leu Gly Ala Val Arg Thr Leu Gly
            260                 265                 270         
Gln Glu Val Ala Lys Gln Gly Ile Arg Ala Asn Cys Ile Ala Pro Gly
        275                 280                 285             
Tyr Val Arg Thr Pro Leu Leu Asp Gly Leu Ser Gln Gly Gly Ala Asn
    290                 295                 300                 
Met Gly Ser Leu Leu Glu Leu Ala Pro Leu Gly Leu Gly Glu Pro Glu
305                 310                 315                 320 
Asp Val Ala Tyr Ala Ala Val Phe Tyr Leu Ser Asp Ala Ser Arg Trp
                325                 330                 335     
Leu Thr Arg Asn Tyr Phe Ile Val Asp Gly Gly Lys Thr Ile Leu Val
            340                 345                 350         
Thr Gly Ala Ser Ser Gly Leu Gly Arg Gln Thr Ala Ile Thr Cys Ala
        355                 360                 365             
Gln Arg Gly Ala Arg Leu Ile Ile Thr Gly Arg Asp Ala Lys Arg Leu
    370                 375                 380                 
Glu Glu Thr Tyr Thr Arg Leu Lys Lys Gly Ala Asp His Val Gln Met
385                 390                 395                 400 
Ser Ala Asp Leu Thr Ser Pro Ala Asp Arg Glu Arg Leu Val Thr Ile
                405                 410                 415     
Ala Ser Ser Val Asn Gly Leu Val His Cys Ala Gly Gln Gln Lys His
            420                 425                 430         
Cys Pro Ile Arg Gln Leu Ser Glu Gln Ala Met Thr Asp Met Tyr Ala
        435                 440                 445             
Ile Asn Phe Leu Ala Pro Val Met Leu Thr Gln Arg Leu Leu Gln Thr
    450                 455                 460                 
Gly Ala Leu Glu Pro Ser Gly Ser Ile Ile Phe Leu Leu Ser Thr Ala
465                 470                 475                 480 
Ala His Ile Gly Thr Arg Gly Val Gly Pro Tyr Ser Ala Met Lys Ala
                485                 490                 495     
Gly Leu Thr Gly Ile Ile Arg Cys Leu Ala Leu Glu Gln Ala Lys Arg
            500                 505                 510         
Lys Ile Arg Val Asn Gly Ile Ser Pro Ser Ala Val Ala Thr Pro Met
        515                 520                 525             
Trp Gly Ala Asp Gln Leu Glu Ala Gln Lys Thr Arg His Pro Leu Gly
    530                 535                 540                 
Leu Gly Thr Pro Glu Asp Val Ala Asn Ala Ala Val Tyr Leu Leu Ser
545                 550                 555                 560 
Asp Ala Ser Arg Trp Val Thr Gly Thr Ser Leu Val Met Asp Gly Gly
                565                 570                 575     
Ala Ile Leu
            


<210> 7706
<211> 928
<212> PRT
<213> Homo sapiens

<400> 7706
Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala
 1               5                  10                  15      
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp
            20                  25                  30          
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu
        35                  40                  45              
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu
    50                  55                  60                  
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys
65                  70                  75                  80  
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys
                85                  90                  95      
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu
            100                 105                 110         
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val
        115                 120                 125             
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val
    130                 135                 140                 
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala
145                 150                 155                 160 
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln
                165                 170                 175     
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys
            180                 185                 190         
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met
        195                 200                 205             
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp
    210                 215                 220                 
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys
225                 230                 235                 240 
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly
                245                 250                 255     
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg
            260                 265                 270         
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val
        275                 280                 285             
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly
    290                 295                 300                 
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg
305                 310                 315                 320 
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe
                325                 330                 335     
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu
            340                 345                 350         
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val
        355                 360                 365             
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln
    370                 375                 380                 
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu
385                 390                 395                 400 
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu
                405                 410                 415     
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys
            420                 425                 430         
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu
        435                 440                 445             
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu
    450                 455                 460                 
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn
465                 470                 475                 480 
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala
                485                 490                 495     
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu
            500                 505                 510         
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe
        515                 520                 525             
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg
    530                 535                 540                 
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser
545                 550                 555                 560 
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser
                565                 570                 575     
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu
            580                 585                 590         
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser
        595                 600                 605             
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser
    610                 615                 620                 
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys
625                 630                 635                 640 
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg
                645                 650                 655     
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu
            660                 665                 670         
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu
        675                 680                 685             
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met
    690                 695                 700                 
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys
705                 710                 715                 720 
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln
                725                 730                 735     
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile
            740                 745                 750         
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile
        755                 760                 765             
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His
    770                 775                 780                 
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro
785                 790                 795                 800 
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser
                805                 810                 815     
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu
            820                 825                 830         
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile
        835                 840                 845             
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu
    850                 855                 860                 
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu
865                 870                 875                 880 
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys
                885                 890                 895     
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln
            900                 905                 910         
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys
        915                 920                 925             


<210> 7707
<211> 1706
<212> PRT
<213> Homo sapiens

<400> 7707
Met Gly Val Pro Lys Phe Tyr Arg Trp Ile Ser Glu Arg Tyr Pro Cys
 1               5                  10                  15      
Leu Ser Glu Val Val Lys Glu His Gln Ile Pro Glu Phe Asp Asn Leu
            20                  25                  30          
Tyr Leu Asp Met Asn Gly Ile Ile His Gln Cys Ser His Pro Asn Asp
        35                  40                  45              
Asp Asp Val His Phe Arg Ile Ser Asp Asp Lys Ile Phe Thr Asp Ile
    50                  55                  60                  
Phe His Tyr Leu Glu Val Leu Phe Arg Ile Ile Lys Pro Arg Lys Val
65                  70                  75                  80  
Phe Phe Met Ala Val Asp Gly Val Ala Pro Arg Ala Lys Met Asn Gln
                85                  90                  95      
Gln Arg Gly Arg Arg Phe Arg Ser Ala Lys Glu Ala Glu Asp Lys Ile
            100                 105                 110         
Lys Lys Ala Ile Glu Lys Gly Glu Thr Leu Pro Thr Glu Ala Arg Phe
        115                 120                 125             
Asp Ser Asn Cys Ile Thr Pro Gly Thr Glu Phe Met Ala Arg Leu His
    130                 135                 140                 
Glu His Leu Lys Tyr Phe Val Asn Met Lys Ile Ser Thr Asp Lys Ser
145                 150                 155                 160 
Trp Gln Gly Val Thr Ile Tyr Phe Ser Gly His Glu Thr Pro Gly Glu
                165                 170                 175     
Gly Glu His Lys Ile Met Glu Phe Ile Arg Ser Glu Lys Ala Lys Pro
            180                 185                 190         
Asp His Asp Pro Asn Thr Arg His Cys Leu Tyr Gly Leu Asp Ala Asp
        195                 200                 205             
Leu Ile Met Leu Gly Leu Thr Ser His Glu Ala His Phe Ser Leu Leu
    210                 215                 220                 
Arg Glu Glu Val Arg Phe Gly Gly Lys Lys Thr Gln Arg Val Cys Ala
225                 230                 235                 240 
Pro Glu Glu Thr Thr Phe His Leu Leu His Leu Ser Leu Met Arg Glu
                245                 250                 255     
Tyr Ile Asp Tyr Glu Phe Ser Val Leu Lys Glu Lys Ile Thr Phe Lys
            260                 265                 270         
Tyr Asp Ile Glu Arg Ile Ile Asp Asp Trp Ile Leu Met Gly Phe Leu
        275                 280                 285             
Val Gly Asn Asp Phe Ile Pro His Leu Pro His Leu His Ile Asn His
    290                 295                 300                 
Asp Ala Leu Pro Leu Leu Tyr Gly Thr Tyr Val Thr Ile Leu Pro Glu
305                 310                 315                 320 
Leu Gly Gly Tyr Ile Asn Glu Ser Gly His Leu Asn Leu Pro Arg Phe
                325                 330                 335     
Glu Lys Tyr Leu Val Lys Leu Ser Asp Phe Asp Arg Glu His Phe Ser
            340                 345                 350         
Glu Val Phe Val Asp Leu Lys Trp Phe Glu Ser Lys Val Gly Asn Lys
        355                 360                 365             
Tyr Leu Asn Glu Ala Ala Gly Val Ala Ala Glu Glu Ala Arg Asn Tyr
    370                 375                 380                 
Lys Glu Lys Lys Lys Leu Lys Gly Gln Glu Asn Ser Leu Cys Trp Thr
385                 390                 395                 400 
Ala Leu Asp Lys Asn Glu Gly Glu Met Ile Thr Ser Lys Asp Asn Leu
                405                 410                 415     
Glu Asp Glu Thr Glu Asp Asp Asp Leu Phe Glu Thr Glu Phe Arg Gln
            420                 425                 430         
Tyr Lys Arg Thr Tyr Tyr Met Thr Lys Met Gly Val Asp Val Val Ser
        435                 440                 445             
Asp Asp Phe Leu Ala Asp Gln Ala Ala Cys Tyr Val Gln Ala Ile Gln
    450                 455                 460                 
Trp Ile Leu His Tyr Tyr Tyr His Gly Val Gln Ser Trp Ser Trp Tyr
465                 470                 475                 480 
Tyr Pro Tyr His Tyr Ala Pro Phe Leu Ser Asp Ile His Asn Ile Ser
                485                 490                 495     
Thr Leu Lys Ile His Phe Glu Leu Gly Lys Pro Phe Lys Pro Phe Glu
            500                 505                 510         
Gln Leu Leu Ala Val Leu Pro Ala Ala Ser Lys Asn Leu Leu Pro Ala
        515                 520                 525             
Cys Tyr Gln His Leu Met Thr Asn Glu Asp Ser Pro Ile Ile Glu Tyr
    530                 535                 540                 
Tyr Pro Pro Asp Phe Lys Thr Asp Leu Asn Gly Lys Gln Gln Glu Trp
545                 550                 555                 560 
Glu Ala Val Val Leu Ile Pro Phe Ile Asp Glu Lys Arg Leu Leu Glu
                565                 570                 575     
Ala Met Glu Thr Cys Asn His Ser Leu Lys Lys Glu Glu Arg Lys Arg
            580                 585                 590         
Asn Gln His Ser Glu Cys Leu Met Cys Trp Tyr Asp Arg Asp Thr Glu
        595                 600                 605             
Phe Ile Tyr Pro Ser Pro Trp Pro Glu Lys Phe Pro Ala Ile Glu Arg
    610                 615                 620                 
Cys Cys Thr Arg Tyr Lys Ile Ile Ser Leu Asp Ala Trp Arg Val Asp
625                 630                 635                 640 
Ile Asn Lys Asn Lys Ile Thr Arg Ile Asp Gln Lys Ala Leu Tyr Phe
                645                 650                 655     
Cys Gly Phe Pro Thr Leu Lys His Ile Arg His Lys Phe Phe Leu Lys
            660                 665                 670         
Lys Ser Gly Val Gln Val Phe Gln Gln Ser Ser Arg Gly Glu Asn Met
        675                 680                 685             
Met Leu Glu Ile Leu Val Asp Ala Glu Ser Asp Glu Leu Thr Val Glu
    690                 695                 700                 
Asn Val Ala Ser Ser Val Leu Gly Lys Ser Val Phe Val Asn Trp Pro
705                 710                 715                 720 
His Leu Glu Glu Ala Arg Val Val Ala Val Ser Asp Gly Glu Thr Lys
                725                 730                 735     
Phe Tyr Leu Glu Glu Pro Pro Gly Thr Gln Lys Leu Tyr Ser Gly Arg
            740                 745                 750         
Thr Ala Pro Pro Ser Lys Val Val His Leu Gly Asp Lys Glu Gln Ser
        755                 760                 765             
Asn Trp Ala Lys Glu Val Gln Gly Ile Ser Glu His Tyr Leu Arg Arg
    770                 775                 780                 
Lys Gly Ile Ile Ile Asn Glu Thr Ser Ala Val Val Tyr Ala Gln Leu
785                 790                 795                 800 
Leu Thr Gly Arg Lys Tyr Gln Ile Asn Gln Asn Gly Glu Val Arg Leu
                805                 810                 815     
Glu Lys Gln Trp Ser Lys Gln Val Val Pro Phe Val Tyr Gln Thr Ile
            820                 825                 830         
Val Lys Asp Ile Arg Ala Phe Asp Ser Arg Phe Ser Asn Ile Lys Thr
        835                 840                 845             
Leu Asp Asp Leu Phe Pro Leu Arg Ser Met Val Phe Met Leu Gly Thr
    850                 855                 860                 
Pro Tyr Tyr Gly Cys Thr Gly Glu Val Gln Asp Ser Gly Asp Val Ile
865                 870                 875                 880 
Thr Glu Gly Arg Ile Arg Val Ile Phe Ser Ile Pro Cys Glu Pro Asn
                885                 890                 895     
Leu Asp Ala Leu Ile Gln Asn Gln His Lys Tyr Ser Ile Lys Tyr Asn
            900                 905                 910         
Pro Gly Tyr Val Leu Ala Ser Arg Leu Gly Val Ser Gly Tyr Leu Val
        915                 920                 925             
Ser Arg Phe Thr Gly Ser Ile Phe Ile Gly Arg Gly Ser Arg Arg Asn
    930                 935                 940                 
Pro His Gly Asp His Lys Ala Asn Val Gly Leu Asn Leu Lys Phe Asn
945                 950                 955                 960 
Lys Lys Asn Glu Glu Val Pro Gly Tyr Thr Lys Lys Val Gly Ser Glu
                965                 970                 975     
Trp Met Tyr Ser Ser Ala Ala Glu Gln Leu Leu Ala Glu Tyr Leu Glu
            980                 985                 990         
Arg Ala Pro Glu Leu Phe Ser Tyr Ile Ala Lys Asn Ser Gln Glu Asp
        995                 1000                1005            
Val Phe Tyr Glu Asp Asp Ile Trp Pro Gly Glu Asn Glu Asn Gly Ala
    1010                1015                1020                
Glu Lys Val Gln Glu Ile Ile Thr Trp Leu Lys Gly His Pro Val Ser
1025                1030                1035                1040
Thr Leu Ser Arg Ser Ser Cys Asp Leu Gln Ile Leu Asp Ala Ala Ile
                1045                1050                1055    
Val Glu Lys Ile Glu Glu Glu Val Glu Lys Cys Lys Gln Arg Lys Asn
            1060                1065                1070        
Asn Lys Lys Val Arg Val Thr Val Lys Pro His Leu Leu Tyr Arg Pro
        1075                1080                1085            
Leu Glu Gln Gln His Gly Val Ile Pro Asp Arg Asp Ala Glu Phe Cys
    1090                1095                1100                
Leu Phe Asp Arg Val Val Asn Val Arg Glu Asn Phe Ser Val Pro Val
1105                1110                1115                1120
Gly Leu Arg Gly Thr Ile Ile Gly Ile Lys Gly Ala Asn Arg Glu Ala
                1125                1130                1135    
Asp Val Leu Phe Glu Val Leu Phe Asp Glu Glu Phe Pro Gly Gly Leu
            1140                1145                1150        
Thr Ile Arg Cys Ser Pro Gly Arg Gly Tyr Arg Leu Pro Thr Ser Ala
        1155                1160                1165            
Leu Val Asn Leu Ser His Gly Ser Arg Ser Glu Thr Gly Asn Gln Lys
    1170                1175                1180                
Leu Thr Ala Ile Val Lys Pro Gln Pro Ala Val His Gln His Ser Ser
1185                1190                1195                1200
Ser Ser Ser Val Ser Ser Gly His Leu Gly Ala Leu Asn His Ser Pro
                1205                1210                1215    
Gln Ser Leu Phe Val Pro Thr Gln Val Pro Thr Lys Asp Asp Asp Glu
            1220                1225                1230        
Phe Cys Asn Ile Trp Gln Ser Leu Gln Gly Ser Gly Lys Met Gln Tyr
        1235                1240                1245            
Phe Gln Pro Thr Ile Gln Glu Lys Gly Ala Val Leu Pro Gln Glu Ile
    1250                1255                1260                
Ser Gln Val Asn Gln His His Lys Ser Gly Phe Asn Asp Asn Ser Val
1265                1270                1275                1280
Lys Tyr Gln Gln Arg Lys His Asp Pro His Arg Lys Phe Lys Glu Glu
                1285                1290                1295    
Cys Lys Ser Pro Lys Ala Glu Cys Trp Ser Gln Lys Met Ser Asn Lys
            1300                1305                1310        
Gln Pro Asn Ser Gly Ile Glu Asn Phe Leu Ala Ser Leu Asn Ile Ser
        1315                1320                1325            
Lys Glu Asn Glu Val Gln Ser Ser His His Gly Glu Pro Pro Ser Glu
    1330                1335                1340                
Glu His Leu Ser Pro Gln Ser Phe Ala Met Gly Thr Arg Met Leu Lys
1345                1350                1355                1360
Glu Ile Leu Lys Ile Asp Gly Ser Asn Thr Val Asp His Lys Asn Glu
                1365                1370                1375    
Ile Lys Gln Ile Ala Asn Glu Ile Pro Val Ser Ser Asn Arg Arg Asp
            1380                1385                1390        
Glu Tyr Gly Leu Pro Ser Gln Pro Lys Gln Asn Lys Lys Leu Ala Ser
        1395                1400                1405            
Tyr Met Asn Lys Pro His Ser Ala Asn Glu Tyr His Asn Val Gln Ser
    1410                1415                1420                
Met Asp Asn Met Cys Trp Pro Ala Pro Ser Gln Ile Pro Pro Val Ser
1425                1430                1435                1440
Thr Pro Val Thr Glu Leu Ser Arg Ile Cys Ser Leu Val Gly Met Pro
                1445                1450                1455    
Gln Pro Asp Phe Ser Phe Leu Arg Met Pro Gln Thr Met Thr Val Cys
            1460                1465                1470        
Gln Val Lys Leu Ser Asn Gly Leu Leu Val His Gly Pro Gln Cys His
        1475                1480                1485            
Ser Glu Asn Glu Ala Lys Glu Lys Ala Ala Leu Phe Ala Leu Gln Gln
    1490                1495                1500                
Leu Gly Ser Leu Gly Met Asn Phe Pro Leu Pro Ser Gln Val Phe Ala
1505                1510                1515                1520
Asn Tyr Pro Ser Ala Val Pro Pro Gly Thr Ile Pro Pro Ala Phe Pro
                1525                1530                1535    
Pro Pro Thr Gly Trp Asp His Tyr Gly Ser Asn Tyr Ala Leu Gly Ala
            1540                1545                1550        
Ala Asn Ile Met Pro Ser Ser Ser His Leu Phe Gly Ser Met Pro Trp
        1555                1560                1565            
Gly Pro Ser Val Pro Val Pro Gly Lys Pro Phe His His Thr Leu Tyr
    1570                1575                1580                
Ser Gly Thr Met Pro Met Ala Gly Gly Ile Pro Gly Gly Val His Asn
1585                1590                1595                1600
Gln Phe Ile Pro Leu Gln Val Thr Lys Lys Arg Val Ala Asn Lys Lys
                1605                1610                1615    
Asn Phe Glu Asn Lys Glu Ala Gln Ser Ser Gln Ala Thr Pro Val Gln
            1620                1625                1630        
Thr Ser Gln Pro Asp Ser Ser Asn Ile Val Lys Val Ser Pro Arg Glu
        1635                1640                1645            
Ser Ser Ser Ala Ser Leu Lys Ser Ser Pro Ile Ala Gln Pro Ala Ser
    1650                1655                1660                
Ser Phe Gln Val Glu Thr Ala Ser Gln Gly His Ser Ile Ser His His
1665                1670                1675                1680
Lys Ser Thr Pro Ile Ser Ser Ser Arg Arg Lys Ser Arg Lys Leu Ala
                1685                1690                1695    
Val Asn Phe Gly Val Ser Lys Pro Ser Glu
            1700                1705    


<210> 7708
<211> 149
<212> PRT
<213> Homo sapiens

<400> 7708
Met Ala Trp Arg Leu Ser Asp Ala Glu Pro Glu Val Arg Ser Asp Ala
 1               5                  10                  15      
Glu Pro Glu Val His Ser Asp Ala Glu Pro Glu Val Arg Ser Asp Ala
            20                  25                  30          
Glu Pro Glu Val Cys Ser Asp Thr Glu Pro Glu Val Leu Ser Pro Leu
        35                  40                  45              
Thr Leu Val Asn Thr Ser Gly Glu Ala Gln Gly Thr Val Asp Arg Val
    50                  55                  60                  
His Ile Gly Gln Val Ile Met Ala Ile Cys Thr Lys Leu Gln Asn Lys
65                  70                  75                  80  
Glu His Val Ile Glu Ala Leu Arg Arg Ala Lys Phe Lys Phe Pro Gly
                85                  90                  95      
Tyr Gln Lys Ile His Val Ser Lys Lys Trp Gly Phe Thr Lys Phe Asn
            100                 105                 110         
Val Asp Glu Phe Glu Asp Met Val Val Glu Glu Trp Leu Ile Pro Asp
        115                 120                 125             
Asp Tyr Gly Val Lys Tyr Ile Pro Ser His Gly Pro Leu Asp Lys Trp
    130                 135                 140                 
Trp Ala Leu Tyr Ser
145                 


<210> 7709
<211> 1562
<212> PRT
<213> Homo sapiens

<400> 7709
Met Val Val Phe Ile Asn Ala Lys Ile Lys Ser Leu Ile Lys Leu Phe
 1               5                  10                  15      
Lys Lys Lys Thr Val Ser Asn Leu Asp Glu Glu Ser Arg Trp Thr Val
            20                  25                  30          
His Tyr Thr Ala Pro Trp His Gln Gln Glu Asn Val Phe Leu Pro Thr
        35                  40                  45              
Thr Arg Pro Pro Cys Val Glu Asp Leu His Arg Gln Ala Lys Leu Asn
    50                  55                  60                  
Leu Lys Ser Val Leu Arg Glu Cys Asp Lys Leu Arg His Asp Gly Tyr
65                  70                  75                  80  
Arg Ser Ser Gln Tyr Tyr Ser Gln Gly Pro Thr Phe Ala Ala Asn Ala
                85                  90                  95      
Ser Pro Phe Cys Asp Asp Tyr Gln Asp Glu Asp Glu Glu Thr Asp Gln
            100                 105                 110         
Lys Cys Ser Leu Ser Ser Ser Glu Glu Glu Arg Phe Ile Ser Ile Arg
        115                 120                 125             
Arg Pro Lys Thr Pro Ala Ser Ser Asp Phe Ser Asp Leu Asn Thr Gln
    130                 135                 140                 
Thr Asn Trp Thr Lys Ser Leu Pro Leu Pro Thr Pro Glu Glu Lys Met
145                 150                 155                 160 
Arg Gln Gln Ala Gln Thr Val Gln Ala Asp Val Val Pro Ile Asn Ile
                165                 170                 175     
Thr Ala Ser Gly Thr Gly Gln Asp Asp Ala Asp Gly His Ser Val Tyr
            180                 185                 190         
Thr Pro Asp His Tyr Ser Thr Leu Gly Arg Phe Asn Ser Cys Arg Ser
        195                 200                 205             
Ala Gly Gln Arg Ser Glu Thr Arg Asp Ser Ser Cys Gln Thr Glu Asp
    210                 215                 220                 
Val Lys Val Val Pro Pro Ser Met Arg Arg Ile Arg Ala Gln Lys Gly
225                 230                 235                 240 
Gln Gly Ile Ala Ala Gln Met Gly His Phe Ser Gly Ser Ser Gly Asn
                245                 250                 255     
Met Ser Val Leu Ser Asp Ser Ala Gly Ile Val Phe Pro Ser Arg Leu
            260                 265                 270         
Asp Ser Asp Ala Gly Phe His Ser Leu Pro Arg Ser Gly Ala Arg Ala
        275                 280                 285             
Asn Ile Gln Ser Leu Glu Pro Arg Leu Gly Ala Leu Gly Pro Ala Gly
    290                 295                 300                 
Asp Met Asn Gly Thr Phe Leu Tyr Gln Arg Gly His Pro Gln Ala Asp
305                 310                 315                 320 
Glu Asn Leu Gly His Leu Gly Gly Ala Ser Gly Thr Gly Thr Leu Leu
                325                 330                 335     
Arg Pro Lys Ser Gln Glu Leu Arg His Phe Glu Ser Glu Asn Ile Met
            340                 345                 350         
Ser Pro Ala Cys Val Val Ser Pro His Ala Thr Tyr Ser Thr Ser Ile
        355                 360                 365             
Ile Pro Asn Ala Thr Leu Ser Ser Ser Ser Glu Val Ile Ala Ile Pro
    370                 375                 380                 
Thr Ala Gln Ser Ala Gly Gln Arg Glu Ser Lys Ser Ser Gly Ser Ser
385                 390                 395                 400 
His Ala Arg Ile Lys Ser Arg Asp His Leu Ile Ser Arg His Ala Val
                405                 410                 415     
Lys Gly Asp Pro Gln Ser Pro Gly Arg His Trp Asn Glu Gly His Ala
            420                 425                 430         
Thr Ile Leu Ser Gln Asp Leu Asp Pro His Ser Pro Gly Glu Pro Ala
        435                 440                 445             
Leu Leu Ser Leu Cys Asp Ser Ala Val Pro Leu Asn Ala Pro Ala Asn
    450                 455                 460                 
Arg Glu Asn Gly Ser Gln Ala Met Pro Tyr Asn Cys Arg Asn Asn Leu
465                 470                 475                 480 
Ala Phe Pro Ala His Pro Gln Asp Val Asp Gly Lys Ser Glu Ser Ser
                485                 490                 495     
Tyr Ser Gly Gly Gly Gly His Ser Ser Ser Glu Pro Trp Glu Tyr Lys
            500                 505                 510         
Ser Ser Gly Asn Gly Arg Ala Ser Pro Leu Lys Pro His Leu Ala Thr
        515                 520                 525             
Pro Gly Tyr Ser Thr Pro Thr Ser Asn Met Ser Ser Cys Ser Leu Asp
    530                 535                 540                 
Gln Thr Ser Asn Lys Glu Asp Ala Gly Ser Leu Tyr Ser Glu Asp His
545                 550                 555                 560 
Asp Gly Tyr Cys Ala Ser Val His Thr Asp Ser Gly His Gly Ser Gly
                565                 570                 575     
Asn Leu Cys Asn Ser Ser Asp Gly Phe Gly Asn Pro Arg His Ser Val
            580                 585                 590         
Ile Asn Val Phe Val Gly Arg Ala Gln Lys Asn Gln Gly Asp Arg Ser
        595                 600                 605             
Asn Tyr Gln Asp Lys Ser Leu Ser Arg Asn Ile Ser Leu Lys Lys Ala
    610                 615                 620                 
Lys Lys Pro Pro Leu Pro Pro Ser Arg Thr Asp Ser Leu Arg Arg Ile
625                 630                 635                 640 
Pro Lys Lys Ser Ser Gln Cys Asn Gly Gln Val Leu Asn Glu Ser Leu
                645                 650                 655     
Ile Ala Thr Leu Gln His Ser Leu Gln Leu Ser Leu Pro Gly Lys Ser
            660                 665                 670         
Gly Ser Ser Pro Ser Gln Ser Pro Cys Ser Asp Leu Glu Glu Pro Trp
        675                 680                 685             
Leu Pro Arg Ser Arg Ser Gln Ser Thr Val Ser Ala Gly Ser Ser Met
    690                 695                 700                 
Thr Ser Ala Thr Thr Pro Asn Val Tyr Ser Leu Cys Gly Ala Thr Pro
705                 710                 715                 720 
Ser Gln Ser Asp Thr Ser Ser Val Lys Ser Glu Tyr Thr Asp Pro Trp
                725                 730                 735     
Gly Tyr Tyr Ile Asp Tyr Thr Gly Met Gln Glu Asp Pro Gly Asn Pro
            740                 745                 750         
Ala Gly Gly Cys Ser Thr Ser Ser Gly Val Pro Thr Gly Asn Gly Pro
        755                 760                 765             
Val Arg His Val Gln Glu Gly Ser Arg Ala Thr Met Pro Gln Val Pro
    770                 775                 780                 
Gly Gly Ser Val Lys Pro Lys Ile Met Ser Pro Glu Lys Ser His Arg
785                 790                 795                 800 
Val Ile Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser Asn Thr Pro Thr
                805                 810                 815     
Ala Leu Thr Pro Val Pro Val Phe Leu Lys Ser Val Ser Pro Ala Asn
            820                 825                 830         
Gly Lys Gly Lys Pro Lys Pro Lys Val Pro Glu Arg Lys Ser Ser Leu
        835                 840                 845             
Ile Ser Ser Val Ser Ile Ser Ser Ser Ser Thr Ser Leu Ser Ser Ser
    850                 855                 860                 
Thr Ser Thr Glu Gly Ser Gly Thr Met Lys Lys Leu Asp Pro Ala Val
865                 870                 875                 880 
Gly Ser Pro Pro Ala Pro Pro Pro Pro Pro Val Pro Ser Pro Pro Phe
                885                 890                 895     
Pro Cys Pro Ala Asp Arg Ser Pro Phe Leu Pro Pro Pro Pro Pro Val
            900                 905                 910         
Thr Asp Cys Ser Gln Gly Ser Pro Leu Pro His Ser Pro Val Phe Pro
        915                 920                 925             
Pro Pro Pro Pro Glu Ala Leu Ile Pro Phe Cys Ser Pro Pro Asp Trp
    930                 935                 940                 
Cys Leu Ser Pro Pro Arg Pro Ala Leu Ser Pro Ile Leu Pro Asp Ser
945                 950                 955                 960 
Pro Val Ser Leu Pro Leu Pro Pro Pro Leu Leu Pro Ser Ser Glu Pro
                965                 970                 975     
Pro Pro Ala Pro Pro Leu Asp Pro Lys Phe Met Lys Asp Thr Arg Pro
            980                 985                 990         
Pro Phe Thr Asn Ser Gly Gln Pro Glu Ser Ser Arg Gly Ser Leu Arg
        995                 1000                1005            
Pro Pro Ser Thr Lys Glu Glu Thr Ser Arg Pro Pro Met Pro Leu Ile
    1010                1015                1020                
Thr Thr Glu Ala Leu Gln Met Val Gln Leu Arg Pro Val Arg Lys Asn
1025                1030                1035                1040
Ser Gly Ala Glu Ala Ala Gln Leu Ser Glu Arg Thr Ala Gln Glu Gln
                1045                1050                1055    
Arg Thr Pro Val Ala Pro Gln Tyr His Leu Lys Pro Ser Ala Phe Leu
            1060                1065                1070        
Lys Ser Arg Asn Ser Thr Asn Glu Met Glu Ser Glu Ser Gln Pro Ala
        1075                1080                1085            
Ser Val Thr Ser Ser Leu Pro Thr Pro Ala Lys Ser Ser Ser Gln Gly
    1090                1095                1100                
Asp His Gly Ser Ala Ala Glu Arg Gly Gly Pro Val Ser Arg Ser Pro
1105                1110                1115                1120
Gly Ala Pro Ser Ala Gly Glu Ala Glu Ala Arg Pro Ser Pro Ser Thr
                1125                1130                1135    
Thr Pro Leu Pro Asp Ser Ser Pro Ser Arg Lys Pro Pro Pro Ile Ser
            1140                1145                1150        
Lys Lys Pro Lys Leu Phe Leu Val Val Pro Pro Pro Gln Lys Asp Phe
        1155                1160                1165            
Ala Val Glu Pro Ala Glu Asn Val Ser Glu Ala Leu Arg Ala Val Pro
    1170                1175                1180                
Ser Pro Thr Thr Gly Glu Glu Gly Ser Val His Ser Arg Glu Ala Lys
1185                1190                1195                1200
Glu Ser Ser Ala Ala Gln Ala Gly Ser His Ala Thr His Pro Gly Thr
                1205                1210                1215    
Ser Val Leu Glu Gly Gly Ala Ala Gly Ser Met Ser Pro Ser Arg Val
            1220                1225                1230        
Glu Ala Asn Val Pro Met Val Gln Pro Asp Val Ser Pro Ala Pro Lys
        1235                1240                1245            
Gln Glu Glu Pro Ala Glu Asn Ser Ala Asp Thr Gly Gly Asp Gly Glu
    1250                1255                1260                
Ser Cys Leu Ser Gln Gln Asp Gly Ala Ala Gly Val Pro Glu Thr Asn
1265                1270                1275                1280
Ala Ala Gly Ser Ser Ser Glu Ala Cys Asp Phe Leu Lys Glu Asp Gly
                1285                1290                1295    
Asn Asp Glu Val Met Thr Pro Ser Arg Pro Arg Thr Thr Glu Asp Leu
            1300                1305                1310        
Phe Ala Ala Ile His Arg Ser Lys Arg Lys Val Leu Gly Arg Arg Asp
        1315                1320                1325            
Ser Asp Asp Asp His Ser Arg Asn His Ser Pro Ser Pro Pro Val Thr
    1330                1335                1340                
Pro Thr Gly Ala Ala Pro Ser Leu Ala Ser Pro Lys Gln Val Gly Ser
1345                1350                1355                1360
Ile Gln Arg Ser Ile Arg Lys Ser Ser Thr Ser Ser Asp Asn Phe Lys
                1365                1370                1375    
Ala Leu Leu Leu Lys Lys Gly Ser Arg Ser Asp Thr Ser Ala Arg Met
            1380                1385                1390        
Ser Ala Ala Glu Met Leu Lys Asn Thr Asp Pro Arg Phe Gln Arg Ser
        1395                1400                1405            
Arg Ser Glu Pro Ser Pro Asp Ala Pro Glu Ser Pro Ser Ser Cys Ser
    1410                1415                1420                
Pro Ser Lys Asn Arg Arg Ala Gln Glu Glu Trp Ala Lys Asn Glu Gly
1425                1430                1435                1440
Leu Met Pro Arg Ser Leu Ser Phe Ser Gly Pro Arg Tyr Gly Arg Ser
                1445                1450                1455    
Arg Thr Pro Pro Ser Ala Ala Ser Ser Arg Tyr Ser Met Arg Asn Arg
            1460                1465                1470        
Ile Gln Ser Ser Pro Met Thr Val Ile Ser Glu Gly Glu Gly Glu Ala
        1475                1480                1485            
Val Glu Pro Val Asp Ser Ile Ala Arg Gly Ala Leu Gly Ala Ala Glu
    1490                1495                1500                
Gly Cys Ser Leu Asp Gly Leu Ala Arg Glu Glu Met Asp Glu Gly Gly
1505                1510                1515                1520
Leu Leu Cys Gly Glu Gly Pro Ala Ala Ser Leu Gln Pro Gln Ala Pro
                1525                1530                1535    
Gly Pro Val Asp Gly Thr Ala Ser Ala Glu Gly Arg Glu Pro Ser Pro
            1540                1545                1550        
Gln Cys Gly Gly Ser Leu Ser Glu Glu Ser
        1555                1560        


<210> 7710
<211> 151
<212> PRT
<213> Homo sapiens

<400> 7710
Met Asn Arg His Leu Cys Val Trp Leu Phe Arg His Pro Ser Leu Asn
 1               5                  10                  15      
Gly Tyr Leu Gln Cys His Ile Gln Leu His Ser His Gln Phe Arg Gln
            20                  25                  30          
Ile His Leu Asp Thr Arg Leu Gln Val Phe Arg Gln Asn Arg Asn Cys
        35                  40                  45              
Ile Leu His Leu Leu Ser Lys Asn Trp Ser Arg Arg Tyr Cys His Gln
    50                  55                  60                  
Asp Thr Lys Met Leu Trp Lys His Lys Ala Leu Gln Lys Tyr Met Glu
65                  70                  75                  80  
Asn Leu Ser Lys Glu Tyr Gln Thr Leu Glu Gln Cys Leu Gln His Ile
                85                  90                  95      
Pro Val Asn Glu Glu Asn Arg Arg Ser Leu Asn Arg Arg His Ala Glu
            100                 105                 110         
Leu Ala Pro Leu Ala Ala Ile Tyr Gln Glu Ile Gln Glu Thr Glu Gln
        115                 120                 125             
Ala Ile Glu Glu Leu Glu Ser Met Cys Lys Lys Thr Glu Ser Cys Ser
    130                 135                 140                 
Val Ala Gln Ala Gly Met Gln
145                 150     


<210> 7711
<211> 275
<212> PRT
<213> Homo sapiens

<400> 7711
Met Ala Gly Leu Gln Arg Leu Ala Ser His Leu Pro Val Gly Val Met
 1               5                  10                  15      
Leu Pro His Asn Thr Thr Glu Ala Pro Gly Pro His Ser Ala Lys Gln
            20                  25                  30          
Asp Ser Tyr Glu Gln Gly Asp Ser Ser Gln Gln Ser Leu Lys Gly His
        35                  40                  45              
Leu Arg Asn Asn Phe Gln Lys Gln Leu Leu Ser Asn Lys Glu Leu Ile
    50                  55                  60                  
Leu Asp Lys Val Tyr Thr His Pro Lys Trp Asn Thr Gln Thr Lys Ala
65                  70                  75                  80  
Arg Ser Tyr Ser Tyr Pro His Cys Thr Gly Ile Ser Gln Gln Asp Pro
                85                  90                  95      
Glu Ser Asp Ser Gln Gly Gln Gly Asn Gly Leu Phe Tyr Ser Ser Gly
            100                 105                 110         
Pro Gln Ser Trp Tyr Pro Lys Ala Asn Asn Gln Asp Phe Ile Pro Phe
        115                 120                 125             
Thr Lys Lys Arg Val Gly Val Asp Arg Ala Phe Pro Leu Lys Pro Met
    130                 135                 140                 
Val His Arg Lys Ser Cys Ser Thr Gly Glu Ala Gly Thr Asp Gly Asp
145                 150                 155                 160 
His Asn Val Tyr Pro Arg Pro Pro Glu Pro Arg Glu Phe Ser Ser Arg
                165                 170                 175     
Asn Phe Gly Val Arg Asn Gln Gly Asn Phe Ser Val Val Gly Thr Val
            180                 185                 190         
Leu Ala Ala Thr Gln Ala Glu Lys Ala Val Ala Asn Phe Asp Arg Thr
        195                 200                 205             
Glu Trp Val Gln Ile Arg Arg Leu Glu Ala Ala Gly Glu Ser Leu Glu
    210                 215                 220                 
Glu Glu Ile Arg Arg Lys Gln Ile Leu Leu Arg Gly Lys Leu Lys Lys
225                 230                 235                 240 
Thr Glu Glu Glu Leu Arg Arg Ile Gln Thr Gln Lys Glu Gln Ala Lys
                245                 250                 255     
Glu Asn Glu Asn Gly Glu Leu Gln Lys Ile Ile Leu Pro Arg Ser Arg
            260                 265                 270         
Val Lys Gly
        275 


<210> 7712
<211> 1411
<212> PRT
<213> Homo sapiens

<400> 7712
Met Leu Arg Arg Ile Leu Gln Arg Thr Pro Gly Arg Val Gly Ser Gln
 1               5                  10                  15      
Gly Ser Asp Leu Asp Ser Ser Ala Thr Pro Ile Asn Thr Val Asp Val
            20                  25                  30          
Asn Asn Glu Ser Ser Ser Glu Gly Phe Ile Cys Pro Gln Cys Met Lys
        35                  40                  45              
Ser Leu Gly Ser Ala Asp Glu Leu Phe Lys His Tyr Glu Ala Val His
    50                  55                  60                  
Asp Ala Gly Asn Asp Ser Gly His Gly Gly Glu Ser Asn Leu Ala Leu
65                  70                  75                  80  
Lys Arg Asp Asp Val Thr Leu Leu Arg Gln Glu Val Gln Asp Leu Gln
                85                  90                  95      
Ala Ser Leu Lys Glu Glu Lys Trp Tyr Ser Glu Glu Leu Lys Lys Glu
            100                 105                 110         
Leu Glu Lys Tyr Gln Gly Leu Gln Gln Gln Glu Ala Lys Pro Asp Gly
        115                 120                 125             
Leu Val Thr Asp Ser Ser Ala Glu Leu Gln Ser Leu Glu Gln Gln Leu
    130                 135                 140                 
Glu Glu Ala Gln Thr Glu Asn Phe Asn Ile Lys Gln Met Lys Asp Leu
145                 150                 155                 160 
Phe Glu Gln Lys Ala Ala Gln Leu Ala Thr Glu Ile Ala Asp Ile Lys
                165                 170                 175     
Ser Lys Tyr Asp Glu Glu Arg Ser Leu Arg Glu Ala Ala Glu Gln Lys
            180                 185                 190         
Val Thr Arg Leu Thr Glu Glu Leu Asn Lys Glu Ala Thr Val Ile Gln
        195                 200                 205             
Asp Leu Lys Thr Glu Leu Leu Gln Arg Pro Gly Ile Glu Asp Val Ala
    210                 215                 220                 
Val Leu Lys Lys Glu Leu Val Gln Val Gln Thr Leu Met Asp Asn Met
225                 230                 235                 240 
Thr Leu Glu Arg Glu Arg Glu Ser Glu Lys Leu Lys Asp Glu Cys Lys
                245                 250                 255     
Lys Leu Gln Ser Gln Tyr Ala Ser Ser Glu Ala Thr Ile Ser Gln Leu
            260                 265                 270         
Arg Ser Glu Leu Ala Lys Gly Pro Gln Glu Val Ala Val Tyr Val Gln
        275                 280                 285             
Glu Leu Gln Lys Leu Lys Ser Ser Val Asn Glu Leu Thr Gln Lys Asn
    290                 295                 300                 
Gln Thr Leu Thr Glu Asn Leu Leu Lys Lys Glu Gln Asp Tyr Thr Lys
305                 310                 315                 320 
Leu Glu Glu Lys His Asn Glu Glu Ser Val Ser Lys Lys Asn Ile Gln
                325                 330                 335     
Ala Thr Leu His Gln Lys Asp Leu Asp Cys Gln Gln Leu Gln Ser Arg
            340                 345                 350         
Leu Ser Ala Ser Glu Thr Ser Leu His Arg Ile His Val Glu Leu Ser
        355                 360                 365             
Glu Lys Gly Glu Ala Thr Gln Lys Leu Lys Glu Glu Leu Ser Glu Val
    370                 375                 380                 
Glu Thr Lys Tyr Gln His Leu Lys Ala Glu Phe Lys Gln Leu Gln Gln
385                 390                 395                 400 
Gln Arg Glu Glu Lys Glu Gln His Gly Leu Gln Leu Gln Ser Glu Ile
                405                 410                 415     
Asn Gln Leu His Ser Lys Leu Leu Glu Thr Glu Arg Gln Leu Gly Glu
            420                 425                 430         
Ala His Gly Arg Leu Lys Glu Gln Arg Gln Leu Ser Ser Glu Lys Leu
        435                 440                 445             
Met Asp Lys Glu Gln Gln Val Ala Asp Leu Gln Leu Lys Leu Ser Arg
    450                 455                 460                 
Leu Glu Glu Gln Leu Lys Glu Lys Val Thr Asn Ser Thr Glu Leu Gln
465                 470                 475                 480 
His Gln Leu Asp Lys Thr Lys Gln Gln His Gln Glu Gln Gln Ala Leu
                485                 490                 495     
Gln Gln Ser Thr Thr Ala Lys Leu Arg Glu Ala Gln Asn Asp Leu Glu
            500                 505                 510         
Gln Val Leu Arg Gln Ile Gly Asp Lys Asp Gln Lys Ile Gln Asn Leu
        515                 520                 525             
Glu Ala Leu Leu Gln Lys Ser Lys Glu Asn Ile Ser Leu Leu Glu Lys
    530                 535                 540                 
Glu Arg Glu Asp Leu Tyr Ala Lys Ile Gln Ala Gly Glu Gly Glu Thr
545                 550                 555                 560 
Ala Val Leu Asn Gln Leu Gln Glu Lys Asn His Thr Leu Gln Glu Gln
                565                 570                 575     
Val Thr Gln Leu Thr Glu Lys Leu Lys Asn Gln Ser Glu Ser His Lys
            580                 585                 590         
Gln Ala Gln Glu Asn Leu His Asp Gln Val Gln Glu Gln Lys Ala His
        595                 600                 605             
Leu Arg Ala Ala Gln Asp Arg Val Leu Ser Leu Glu Thr Ser Val Asn
    610                 615                 620                 
Glu Leu Asn Ser Gln Leu Asn Glu Ser Lys Glu Lys Val Ser Gln Leu
625                 630                 635                 640 
Asp Ile Gln Ile Lys Ala Lys Thr Glu Leu Leu Leu Ser Ala Glu Ala
                645                 650                 655     
Ala Lys Thr Ala Gln Arg Ala Asp Leu Gln Asn His Leu Asp Thr Ala
            660                 665                 670         
Gln Asn Ala Leu Gln Asp Lys Gln Gln Glu Leu Asn Lys Ile Thr Thr
        675                 680                 685             
Gln Leu Asp Gln Val Thr Ala Lys Leu Gln Asp Lys Gln Glu His Cys
    690                 695                 700                 
Ser Gln Leu Glu Ser His Leu Lys Glu Tyr Lys Glu Lys Tyr Leu Ser
705                 710                 715                 720 
Leu Glu Gln Lys Thr Glu Glu Leu Glu Gly Gln Ile Lys Lys Leu Glu
                725                 730                 735     
Ala Asp Ser Leu Glu Val Lys Ala Ser Lys Glu Gln Ala Leu Gln Asp
            740                 745                 750         
Leu Gln Gln Gln Arg Gln Leu Asn Thr Asp Leu Glu Leu Arg Ala Thr
        755                 760                 765             
Glu Leu Ser Lys Gln Leu Glu Met Glu Lys Glu Ile Val Ser Ser Thr
    770                 775                 780                 
Arg Leu Asp Leu Gln Lys Lys Ser Glu Ala Leu Glu Ser Ile Lys Gln
785                 790                 795                 800 
Lys Leu Thr Lys Gln Glu Glu Glu Lys Gln Ile Leu Lys Gln Asp Phe
                805                 810                 815     
Glu Thr Leu Ser Gln Glu Thr Lys Ile Gln His Glu Glu Leu Asn Asn
            820                 825                 830         
Arg Ile Gln Thr Thr Val Thr Glu Leu Gln Lys Val Lys Met Glu Lys
        835                 840                 845             
Glu Ala Leu Met Thr Glu Leu Ser Thr Val Lys Asp Lys Leu Ser Lys
    850                 855                 860                 
Val Ser Asp Ser Leu Lys Asn Ser Lys Ser Glu Phe Glu Lys Glu Asn
865                 870                 875                 880 
Gln Lys Gly Lys Ala Ala Ile Leu Asp Leu Glu Lys Thr Cys Lys Glu
                885                 890                 895     
Leu Lys His Gln Leu Gln Val Gln Met Glu Asn Thr Leu Lys Glu Gln
            900                 905                 910         
Lys Glu Leu Lys Lys Ser Leu Glu Lys Glu Lys Glu Ala Ser His Gln
        915                 920                 925             
Leu Lys Leu Glu Leu Asn Ser Met Gln Glu Gln Leu Ile Gln Ala Gln
    930                 935                 940                 
Asn Thr Leu Lys Gln Asn Glu Lys Glu Glu Gln Gln Leu Gln Gly Asn
945                 950                 955                 960 
Ile Asn Glu Leu Lys Gln Ser Ser Glu Gln Lys Lys Lys Gln Ile Glu
                965                 970                 975     
Ala Leu Gln Gly Glu Leu Lys Ile Ala Val Leu Gln Lys Thr Glu Leu
            980                 985                 990         
Glu Asn Lys Leu Gln Gln Gln Leu Thr Gln Ala Ala Gln Glu Leu Ala
        995                 1000                1005            
Ala Glu Lys Glu Lys Ile Ser Val Leu Gln Asn Asn Tyr Glu Lys Ser
    1010                1015                1020                
Gln Glu Thr Phe Lys Gln Leu Gln Ser Asp Phe Tyr Gly Arg Glu Ser
1025                1030                1035                1040
Glu Leu Leu Ala Thr Arg Gln Asp Leu Lys Ser Val Glu Glu Lys Leu
                1045                1050                1055    
Ser Leu Ala Gln Glu Asp Leu Ile Ser Asn Arg Asn Gln Ile Gly Asn
            1060                1065                1070        
Gln Asn Lys Leu Ile Gln Glu Leu Lys Thr Ala Lys Ala Thr Leu Glu
        1075                1080                1085            
Gln Asp Ser Ala Lys Lys Glu Gln Gln Leu Gln Glu Arg Cys Lys Ala
    1090                1095                1100                
Leu Gln Asp Ile Gln Lys Glu Lys Ser Leu Lys Glu Lys Glu Leu Val
1105                1110                1115                1120
Asn Glu Lys Ser Lys Leu Ala Glu Ile Glu Glu Ile Lys Cys Arg Gln
                1125                1130                1135    
Glu Lys Glu Ile Thr Lys Leu Asn Glu Glu Leu Lys Ser His Lys Leu
            1140                1145                1150        
Glu Ser Ile Lys Glu Ile Thr Asn Leu Lys Asp Ala Lys Gln Leu Leu
        1155                1160                1165            
Ile Gln Gln Lys Leu Glu Leu Gln Gly Lys Ala Asp Ser Leu Lys Ala
    1170                1175                1180                
Ala Val Glu Gln Glu Lys Arg Asn Gln Gln Ile Leu Lys Asp Gln Val
1185                1190                1195                1200
Lys Lys Glu Glu Glu Glu Leu Lys Lys Glu Phe Ile Glu Lys Glu Ala
                1205                1210                1215    
Lys Leu His Ser Glu Ile Lys Glu Lys Glu Val Gly Met Lys Lys His
            1220                1225                1230        
Glu Glu Asn Glu Ala Lys Leu Thr Met Gln Ile Thr Ala Leu Asn Glu
        1235                1240                1245            
Asn Leu Gly Thr Val Lys Lys Glu Trp Gln Ser Ser Gln Arg Arg Val
    1250                1255                1260                
Ser Glu Leu Glu Lys Gln Thr Asp Asp Leu Arg Gly Glu Ile Ala Val
1265                1270                1275                1280
Leu Glu Ala Thr Val Gln Asn Asn Gln Asp Glu Arg Arg Ala Leu Leu
                1285                1290                1295    
Glu Arg Cys Leu Lys Gly Glu Gly Glu Ile Glu Lys Leu Gln Thr Lys
            1300                1305                1310        
Val Leu Glu Leu Gln Arg Lys Leu Asp Asn Thr Thr Ala Ala Val Gln
        1315                1320                1325            
Glu Leu Gly Arg Glu Asn Gln Ser Leu Gln Ile Lys His Thr Gln Ala
    1330                1335                1340                
Leu Asn Arg Lys Trp Ala Glu Asp Asn Glu Val Gln Asn Cys Met Ala
1345                1350                1355                1360
Cys Gly Lys Gly Phe Ser Val Thr Val Arg Arg His His Cys Arg Gln
                1365                1370                1375    
Cys Gly Asn Ile Phe Cys Ala Glu Cys Ser Ala Lys Asn Ala Leu Thr
            1380                1385                1390        
Pro Ser Ser Lys Lys Pro Val Arg Val Cys Asp Ala Cys Phe Asn Asp
        1395                1400                1405            
Leu Gln Gly
    1410    


<210> 7713
<211> 1153
<212> PRT
<213> Homo sapiens

<400> 7713
Met Gly Asp Thr Ala Pro Pro Gln Ala Pro Ala Gly Gly Leu Gly Gly
 1               5                  10                  15      
Ala Ser Gly Ala Gly Leu Leu Gly Gly Gly Ser Val Thr Pro Arg Val
            20                  25                  30          
His Ser Ala Ile Val Glu Arg Leu Arg Ala Arg Ile Ala Val Cys Arg
        35                  40                  45              
Gln His His Leu Ser Cys Glu Gly Arg Tyr Glu Arg Gly Arg Ala Glu
    50                  55                  60                  
Ser Ser Asp Arg Glu Arg Glu Ser Thr Leu Gln Leu Leu Ser Leu Val
65                  70                  75                  80  
Gln His Gly Gln Gly Ala Arg Lys Ala Gly Lys His Thr Lys Ala Thr
                85                  90                  95      
Ala Thr Ala Ala Thr Thr Thr Ala Pro Pro Pro Pro Pro Ala Ala Pro
            100                 105                 110         
Pro Ala Ala Ser Gln Ala Ala Ala Thr Ala Ala Pro Pro Pro Pro Pro
        115                 120                 125             
Asp Tyr His His His His Gln Gln His Leu Leu Asn Ser Ser Asn Asn
    130                 135                 140                 
Gly Gly Ser Gly Gly Ile Asn Gly Glu Gln Gln Pro Pro Ala Ser Thr
145                 150                 155                 160 
Pro Gly Asp Gln Arg Asn Ser Ala Leu Ile Ala Leu Gln Gly Ser Leu
                165                 170                 175     
Lys Arg Lys Gln Val Val Asn Leu Ser Pro Ala Asn Ser Lys Arg Pro
            180                 185                 190         
Asn Gly Phe Val Asp Asn Ser Phe Leu Asp Ile Lys Arg Ile Arg Val
        195                 200                 205             
Gly Glu Asn Leu Ser Ala Gly Gln Gly Gly Leu Gln Ile Asn Asn Gly
    210                 215                 220                 
Gln Ser Gln Ile Met Ser Gly Thr Leu Pro Met Ser Gln Ala Pro Leu
225                 230                 235                 240 
Arg Lys Thr Asn Thr Leu Pro Ser His Thr His Ser Pro Gly Asn Gly
                245                 250                 255     
Leu Phe Asn Met Gly Leu Lys Glu Val Lys Lys Glu Pro Gly Glu Thr
            260                 265                 270         
Leu Ser Cys Ser Lys His Met Asp Gly Gln Met Thr Gln Glu Asn Ile
        275                 280                 285             
Phe Pro Asn Arg Tyr Gly Asp Asp Pro Gly Glu Gln Leu Met Asp Pro
    290                 295                 300                 
Glu Leu Gln Glu Leu Phe Asn Glu Leu Thr Asn Ile Ser Val Pro Pro
305                 310                 315                 320 
Met Ser Asp Leu Glu Leu Glu Asn Met Ile Asn Ala Thr Ile Lys Gln
                325                 330                 335     
Asp Asp Pro Phe Asn Ile Asp Leu Gly Gln Gln Ser Gln Arg Ser Thr
            340                 345                 350         
Pro Arg Pro Ser Leu Pro Met Glu Lys Ile Val Ile Lys Ser Glu Tyr
        355                 360                 365             
Ser Pro Gly Leu Thr Gln Gly Pro Ser Gly Ser Pro Gln Leu Arg Pro
    370                 375                 380                 
Pro Ser Ala Gly Pro Ala Phe Ser Met Ala Asn Ser Ala Leu Ser Thr
385                 390                 395                 400 
Ser Ser Pro Ile Pro Ser Val Pro Gln Ser Gln Ala Gln Pro Gln Thr
                405                 410                 415     
Gly Ser Gly Ala Ser Arg Ala Leu Pro Ser Trp Gln Glu Val Ser His
            420                 425                 430         
Ala Gln Gln Leu Lys Gln Ile Ala Ala Asn Arg Gln Gln His Ala Arg
        435                 440                 445             
Met Gln Gln His Gln Gln Gln His Gln Pro Thr Asn Trp Ser Ala Leu
    450                 455                 460                 
Pro Ser Ser Ala Gly Pro Ser Pro Gly Pro Phe Gly Gln Glu Lys Ile
465                 470                 475                 480 
Pro Ser Pro Ser Phe Gly Gln Gln Thr Phe Ser Pro Gln Ser Ser Pro
                485                 490                 495     
Met Pro Gly Val Ala Gly Gly Ser Gly Gln Ser Lys Val Met Ala Asn
            500                 505                 510         
Tyr Met Tyr Lys Ala Gly Pro Ser Ala Gln Gly Gly His Leu Asp Val
        515                 520                 525             
Leu Met Gln Gln Lys Pro Gln Asp Leu Ser Arg Ser Phe Ile Asn Asn
    530                 535                 540                 
Pro His Pro Ala Met Glu Pro Arg Gln Gly Asn Thr Lys Pro Leu Phe
545                 550                 555                 560 
His Phe Asn Ser Asp Gln Ala Asn Gln Gln Met Pro Ser Val Leu Pro
                565                 570                 575     
Ser Gln Asn Lys Pro Ser Leu Leu His Tyr Thr Gln Gln Gln Gln Gln
            580                 585                 590         
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        595                 600                 605             
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ser Ser Ile Ser Ala Gln
    610                 615                 620                 
Gln Gln Gln Gln Gln Gln Ser Ser Ile Ser Ala Gln Gln Gln Gln Gln
625                 630                 635                 640 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
                645                 650                 655     
Gln Gln Gln Gln Gln Gln Pro Ser Ser Gln Pro Ala Gln Ser Leu Pro
            660                 665                 670         
Ser Gln Pro Leu Leu Arg Ser Pro Leu Pro Leu Gln Gln Lys Leu Leu
        675                 680                 685             
Leu Gln Gln Met Gln Asn Gln Pro Ile Ala Gly Met Gly Tyr Gln Val
    690                 695                 700                 
Ser Gln Gln Gln Arg Gln Asp Gln His Ser Val Val Gly Gln Asn Thr
705                 710                 715                 720 
Gly Pro Ser Pro Ser Pro Asn Pro Cys Ser Asn Pro Asn Thr Gly Ser
                725                 730                 735     
Gly Tyr Met Asn Ser Gln Gln Ser Leu Leu Asn Gln Gln Leu Met Gly
            740                 745                 750         
Lys Lys Gln Thr Leu Gln Arg Gln Ile Met Glu Gln Lys Gln Gln Leu
        755                 760                 765             
Leu Leu Gln Gln Gln Met Leu Ala Asp Ala Glu Lys Ile Ala Pro Gln
    770                 775                 780                 
Asp Gln Ile Asn Arg His Leu Ser Arg Pro Pro Pro Asp Tyr Lys Asp
785                 790                 795                 800 
Gln Arg Arg Asn Val Gly Asn Met Gln Pro Thr Ala Gln Tyr Ser Gly
                805                 810                 815     
Gly Ser Ser Thr Ile Ser Leu Asn Ser Asn Gln Ala Leu Ala Asn Pro
            820                 825                 830         
Val Ser Thr His Thr Ile Leu Thr Pro Asn Ser Ser Leu Leu Ser Thr
        835                 840                 845             
Ser His Gly Thr Arg Met Pro Ser Leu Ser Thr Ala Val Gln Asn Met
    850                 855                 860                 
Gly Met Tyr Gly Asn Leu Pro Cys Asn Gln Pro Asn Thr Tyr Ser Val
865                 870                 875                 880 
Thr Ser Gly Met Asn Gln Leu Thr Gln Gln Arg Asn Pro Lys Gln Leu
                885                 890                 895     
Leu Ala Asn Gln Asn Asn Pro Met Met Pro Arg Pro Pro Thr Leu Gly
            900                 905                 910         
Pro Ser Asn Asn Asn Asn Val Ala Thr Phe Gly Ala Gly Ser Val Gly
        915                 920                 925             
Asn Ser Gln Gln Leu Arg Pro Asn Leu Thr His Ser Met Ala Ser Met
    930                 935                 940                 
Pro Pro Gln Arg Thr Ser Asn Val Met Ile Thr Ser Asn Thr Thr Ala
945                 950                 955                 960 
Pro Asn Trp Ala Ser Gln Glu Gly Thr Ser Lys Gln Gln Glu Ala Leu
                965                 970                 975     
Thr Ser Ala Gly Val Arg Phe Pro Thr Gly Thr Pro Ala Ala Tyr Thr
            980                 985                 990         
Pro Asn Gln Ser Leu Gln Gln Ala Val Gly Ser Gln Gln Phe Ser Gln
        995                 1000                1005            
Arg Ala Val Ala Pro Pro Asn Gln Leu Thr Pro Ala Val Gln Met Arg
    1010                1015                1020                
Pro Met Asn Gln Met Ser Gln Thr Leu Asn Gly Gln Thr Met Gly Pro
1025                1030                1035                1040
Leu Arg Gly Leu Asn Leu Arg Pro Asn Gln Leu Ser Thr Gln Ile Leu
                1045                1050                1055    
Pro Asn Leu Asn Gln Ser Gly Thr Gly Leu Asn Gln Ser Arg Thr Gly
            1060                1065                1070        
Ile Asn Gln Pro Pro Ser Leu Thr Pro Ser Asn Phe Pro Ser Pro Asn
        1075                1080                1085            
Gln Ser Ser Arg Ala Phe Gln Gly Thr Asp His Ser Ser Asp Leu Ala
    1090                1095                1100                
Phe Asp Phe Leu Ser Gln Gln Asn Asp Asn Met Gly Pro Ala Leu Asn
1105                1110                1115                1120
Ser Asp Ala Asp Phe Ile Asp Ser Leu Leu Lys Thr Glu Pro Gly Asn
                1125                1130                1135    
Asp Asp Trp Met Lys Asp Ile Asn Leu Asp Glu Ile Leu Gly Asn Asn
            1140                1145                1150        
Ser
    


<210> 7714
<211> 1173
<212> PRT
<213> Homo sapiens

<400> 7714
Pro Ala Val Ala Ser Phe His Leu Thr Ile Pro Glu Ala Ala Ile Ile
 1               5                  10                  15      
Val Ser Gly Lys Met Gly Asp Thr Ala Pro Pro Gln Ala Pro Ala Gly
            20                  25                  30          
Gly Leu Gly Gly Ala Ser Gly Ala Gly Leu Leu Gly Gly Gly Ser Val
        35                  40                  45              
Thr Pro Arg Val His Ser Ala Ile Val Glu Arg Leu Arg Ala Arg Ile
    50                  55                  60                  
Ala Val Cys Arg Gln His His Leu Ser Cys Glu Gly Arg Tyr Glu Arg
65                  70                  75                  80  
Gly Arg Ala Glu Ser Ser Asp Arg Glu Arg Glu Ser Thr Leu Gln Leu
                85                  90                  95      
Leu Ser Leu Val Gln His Gly Gln Gly Ala Arg Lys Ala Gly Lys His
            100                 105                 110         
Thr Lys Ala Thr Ala Thr Ala Ala Thr Thr Thr Ala Pro Pro Pro Pro
        115                 120                 125             
Pro Ala Ala Pro Pro Ala Ala Ser Gln Ala Ala Ala Thr Ala Ala Pro
    130                 135                 140                 
Pro Pro Pro Pro Asp Tyr His His His His Gln Gln His Leu Leu Asn
145                 150                 155                 160 
Ser Ser Asn Asn Gly Gly Ser Gly Gly Ile Asn Gly Glu Gln Gln Pro
                165                 170                 175     
Pro Ala Ser Thr Pro Gly Asp Gln Arg Asn Ser Ala Leu Ile Ala Leu
            180                 185                 190         
Gln Gly Ser Leu Lys Arg Lys Gln Val Val Asn Leu Ser Pro Ala Asn
        195                 200                 205             
Ser Lys Arg Pro Asn Gly Phe Val Asp Asn Ser Phe Leu Asp Ile Lys
    210                 215                 220                 
Arg Ile Arg Val Gly Glu Asn Leu Ser Ala Gly Gln Gly Gly Leu Gln
225                 230                 235                 240 
Ile Asn Asn Gly Gln Ser Gln Ile Met Ser Gly Thr Leu Pro Met Ser
                245                 250                 255     
Gln Ala Pro Leu Arg Lys Thr Asn Thr Leu Pro Ser His Thr His Ser
            260                 265                 270         
Pro Gly Asn Gly Leu Phe Asn Met Gly Leu Lys Glu Val Lys Lys Glu
        275                 280                 285             
Pro Gly Glu Thr Leu Ser Cys Ser Lys His Met Asp Gly Gln Met Thr
    290                 295                 300                 
Gln Glu Asn Ile Phe Pro Asn Arg Tyr Gly Asp Asp Pro Gly Glu Gln
305                 310                 315                 320 
Leu Met Asp Pro Glu Leu Gln Glu Leu Phe Asn Glu Leu Thr Asn Ile
                325                 330                 335     
Ser Val Pro Pro Met Ser Asp Leu Glu Leu Glu Asn Met Ile Asn Ala
            340                 345                 350         
Thr Ile Lys Gln Asp Asp Pro Phe Asn Ile Asp Leu Gly Gln Gln Ser
        355                 360                 365             
Gln Arg Ser Thr Pro Arg Pro Ser Leu Pro Met Glu Lys Ile Val Ile
    370                 375                 380                 
Lys Ser Glu Tyr Ser Pro Gly Leu Thr Gln Gly Pro Ser Gly Ser Pro
385                 390                 395                 400 
Gln Leu Arg Pro Pro Ser Ala Gly Pro Ala Phe Ser Met Ala Asn Ser
                405                 410                 415     
Ala Leu Ser Thr Ser Ser Pro Ile Pro Ser Val Pro Gln Ser Gln Ala
            420                 425                 430         
Gln Pro Gln Thr Gly Ser Gly Ala Ser Arg Ala Leu Pro Ser Trp Gln
        435                 440                 445             
Glu Val Ser His Ala Gln Gln Leu Lys Gln Ile Ala Ala Asn Arg Gln
    450                 455                 460                 
Gln His Ala Arg Met Gln Gln His Gln Gln Gln His Gln Pro Thr Asn
465                 470                 475                 480 
Trp Ser Ala Leu Pro Ser Ser Ala Gly Pro Ser Pro Gly Pro Phe Gly
                485                 490                 495     
Gln Glu Lys Ile Pro Ser Pro Ser Phe Gly Gln Gln Thr Phe Ser Pro
            500                 505                 510         
Gln Ser Ser Pro Met Pro Gly Val Ala Gly Gly Ser Gly Gln Ser Lys
        515                 520                 525             
Val Met Ala Asn Tyr Met Tyr Lys Ala Gly Pro Ser Ala Gln Gly Gly
    530                 535                 540                 
His Leu Asp Val Leu Met Gln Gln Lys Pro Gln Asp Leu Ser Arg Ser
545                 550                 555                 560 
Phe Ile Asn Asn Pro His Pro Ala Met Glu Pro Arg Gln Gly Asn Thr
                565                 570                 575     
Lys Pro Leu Phe His Phe Asn Ser Asp Gln Ala Asn Gln Gln Met Pro
            580                 585                 590         
Ser Val Leu Pro Ser Gln Asn Lys Pro Ser Leu Leu His Tyr Thr Gln
        595                 600                 605             
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    610                 615                 620                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ser Ser
625                 630                 635                 640 
Ile Ser Ala Gln Gln Gln Gln Gln Gln Gln Ser Ser Ile Ser Ala Gln
                645                 650                 655     
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            660                 665                 670         
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Ser Ser Gln Pro Ala
        675                 680                 685             
Gln Ser Leu Pro Ser Gln Pro Leu Leu Arg Ser Pro Leu Pro Leu Gln
    690                 695                 700                 
Gln Lys Leu Leu Leu Gln Gln Met Gln Asn Gln Pro Ile Ala Gly Met
705                 710                 715                 720 
Gly Tyr Gln Val Ser Gln Gln Gln Arg Gln Asp Gln His Ser Val Val
                725                 730                 735     
Gly Gln Asn Thr Gly Pro Ser Pro Ser Pro Asn Pro Cys Ser Asn Pro
            740                 745                 750         
Asn Thr Gly Ser Gly Tyr Met Asn Ser Gln Gln Ser Leu Leu Asn Gln
        755                 760                 765             
Gln Leu Met Gly Lys Lys Gln Thr Leu Gln Arg Gln Ile Met Glu Gln
    770                 775                 780                 
Lys Gln Gln Leu Leu Leu Gln Gln Gln Met Leu Ala Asp Ala Glu Lys
785                 790                 795                 800 
Ile Ala Pro Gln Asp Gln Ile Asn Arg His Leu Ser Arg Pro Pro Pro
                805                 810                 815     
Asp Tyr Lys Asp Gln Arg Arg Asn Val Gly Asn Met Gln Pro Thr Ala
            820                 825                 830         
Gln Tyr Ser Gly Gly Ser Ser Thr Ile Ser Leu Asn Ser Asn Gln Ala
        835                 840                 845             
Leu Ala Asn Pro Val Ser Thr His Thr Ile Leu Thr Pro Asn Ser Ser
    850                 855                 860                 
Leu Leu Ser Thr Ser His Gly Thr Arg Met Pro Ser Leu Ser Thr Ala
865                 870                 875                 880 
Val Gln Asn Met Gly Met Tyr Gly Asn Leu Pro Cys Asn Gln Pro Asn
                885                 890                 895     
Thr Tyr Ser Val Thr Ser Gly Met Asn Gln Leu Thr Gln Gln Arg Asn
            900                 905                 910         
Pro Lys Gln Leu Leu Ala Asn Gln Asn Asn Pro Met Met Pro Arg Pro
        915                 920                 925             
Pro Thr Leu Gly Pro Ser Asn Asn Asn Asn Val Ala Thr Phe Gly Ala
    930                 935                 940                 
Gly Ser Val Gly Asn Ser Gln Gln Leu Arg Pro Asn Leu Thr His Ser
945                 950                 955                 960 
Met Ala Ser Met Pro Pro Gln Arg Thr Ser Asn Val Met Ile Thr Ser
                965                 970                 975     
Asn Thr Thr Ala Pro Asn Trp Ala Ser Gln Glu Gly Thr Ser Lys Gln
            980                 985                 990         
Gln Glu Ala Leu Thr Ser Ala Gly Val Arg Phe Pro Thr Gly Thr Pro
        995                 1000                1005            
Ala Ala Tyr Thr Pro Asn Gln Ser Leu Gln Gln Ala Val Gly Ser Gln
    1010                1015                1020                
Gln Phe Ser Gln Arg Ala Val Ala Pro Pro Asn Gln Leu Thr Pro Ala
1025                1030                1035                1040
Val Gln Met Arg Pro Met Asn Gln Met Ser Gln Thr Leu Asn Gly Gln
                1045                1050                1055    
Thr Met Gly Pro Leu Arg Gly Leu Asn Leu Arg Pro Asn Gln Leu Ser
            1060                1065                1070        
Thr Gln Ile Leu Pro Asn Leu Asn Gln Ser Gly Thr Gly Leu Asn Gln
        1075                1080                1085            
Ser Arg Thr Gly Ile Asn Gln Pro Pro Ser Leu Thr Pro Ser Asn Phe
    1090                1095                1100                
Pro Ser Pro Asn Gln Ser Ser Arg Ala Phe Gln Gly Thr Asp His Ser
1105                1110                1115                1120
Ser Asp Leu Ala Phe Asp Phe Leu Ser Gln Gln Asn Asp Asn Met Gly
                1125                1130                1135    
Pro Ala Leu Asn Ser Asp Ala Asp Phe Ile Asp Ser Leu Leu Lys Thr
            1140                1145                1150        
Glu Pro Gly Asn Asp Asp Trp Met Lys Asp Ile Asn Leu Asp Glu Ile
        1155                1160                1165            
Leu Gly Asn Asn Ser
    1170            


<210> 7715
<211> 522
<212> PRT
<213> Homo sapiens

<400> 7715
Met Pro Arg Lys Lys Ala Ala Ala Ala Ala Trp Glu Glu Pro Ser Ser
 1               5                  10                  15      
Gly Asn Gly Thr Ala Arg Ala Gly Pro Arg Lys Arg Gly Gly Pro Ala
            20                  25                  30          
Gly Arg Lys Arg Glu Arg Pro Glu Arg Cys Ser Ser Ser Ser Gly Gly
        35                  40                  45              
Gly Ser Ser Gly Asp Glu Asp Gly Leu Glu Leu Asp Gly Ala Pro Gly
    50                  55                  60                  
Gly Gly Lys Arg Ala Ala Arg Pro Ala Thr Ala Gly Lys Ala Gly Gly
65                  70                  75                  80  
Ala Ala Val Val Ile Thr Glu Pro Glu His Thr Lys Glu Arg Val Lys
                85                  90                  95      
Leu Glu Gly Ser Lys Cys Lys Gly Gln Leu Leu Ile Phe Gly Ala Thr
            100                 105                 110         
Asn Trp Asp Leu Ile Gly Arg Lys Glu Val Pro Lys Gln Gln Ala Ala
        115                 120                 125             
Tyr Arg Asn Leu Gly Gln Asn Leu Trp Gly Pro His Arg Tyr Gly Cys
    130                 135                 140                 
Leu Ala Gly Val Arg Val Arg Thr Val Val Ser Gly Ser Cys Ala Ala
145                 150                 155                 160 
His Ser Leu Leu Ile Thr Thr Glu Gly Lys Leu Trp Ser Trp Gly Arg
                165                 170                 175     
Asn Glu Lys Gly Gln Leu Gly His Gly Asp Thr Lys Arg Val Glu Ala
            180                 185                 190         
Pro Arg Leu Ile Glu Gly Leu Ser His Glu Val Ile Val Ser Ala Ala
        195                 200                 205             
Cys Gly Arg Asn His Thr Leu Ala Leu Thr Glu Thr Gly Ser Val Phe
    210                 215                 220                 
Ala Phe Gly Glu Asn Lys Met Gly Gln Leu Gly Leu Gly Asn Gln Thr
225                 230                 235                 240 
Asp Ala Val Pro Ser Pro Ala Gln Ile Met Tyr Asn Gly Gln Pro Ile
                245                 250                 255     
Thr Lys Met Ala Cys Gly Ala Glu Phe Ser Met Ile Met Asp Cys Lys
            260                 265                 270         
Gly Asn Leu Tyr Ser Phe Gly Cys Pro Glu Tyr Gly Gln Leu Gly His
        275                 280                 285             
Asn Ser Asp Gly Lys Phe Ile Ala Arg Ala Gln Arg Ile Glu Tyr Asp
    290                 295                 300                 
Cys Glu Leu Val Pro Arg Arg Val Ala Ile Phe Ile Glu Lys Thr Lys
305                 310                 315                 320 
Asp Gly Gln Ile Leu Pro Val Pro Asn Val Val Val Arg Asp Val Ala
                325                 330                 335     
Cys Gly Ala Asn His Thr Leu Val Leu Asp Ser Gln Lys Arg Val Phe
            340                 345                 350         
Ser Trp Gly Phe Gly Gly Tyr Gly Arg Leu Gly His Ala Glu Gln Lys
        355                 360                 365             
Asp Glu Met Val Pro Arg Leu Val Lys Leu Phe Asp Phe Pro Gly Arg
    370                 375                 380                 
Gly Ala Ser Gln Ile Tyr Ala Gly Tyr Thr Cys Ser Phe Ala Val Ser
385                 390                 395                 400 
Glu Val Gly Gly Leu Phe Phe Trp Gly Ala Thr Asn Thr Ser Arg Glu
                405                 410                 415     
Ser Thr Met Tyr Pro Lys Ala Val Gln Asp Leu Cys Gly Trp Arg Ile
            420                 425                 430         
Arg Ser Leu Ala Cys Gly Lys Ser Ser Ile Ile Val Ala Ala Asp Glu
        435                 440                 445             
Ser Thr Ile Ser Trp Gly Pro Ser Pro Thr Phe Gly Glu Leu Gly Tyr
    450                 455                 460                 
Gly Asp His Lys Pro Lys Ser Ser Thr Ala Ala Gln Glu Val Lys Thr
465                 470                 475                 480 
Leu Asp Gly Ile Phe Ser Glu Gln Val Ala Met Gly Tyr Ser His Ser
                485                 490                 495     
Leu Val Ile Ala Arg Asp Glu Ser Glu Thr Glu Lys Glu Lys Ile Lys
            500                 505                 510         
Lys Leu Pro Glu Tyr Asn Pro Arg Thr Leu
        515                 520         


<210> 7716
<211> 1584
<212> PRT
<213> Homo sapiens

<400> 7716
Gln Ala Leu Glu Pro Ala Gly Gly Asp Glu Asp Gly Ala Arg Arg Cys
 1               5                  10                  15      
Arg Thr Ala Ala Cys Ala Val Ser Ala Val Ala Ala Ala Gln Gly Arg
            20                  25                  30          
Ser Glu Gly Cys Gly Gly Val Gly Tyr Ala His Thr Leu His Leu Leu
        35                  40                  45              
Pro Phe Ala Gly Ser Ser Val Val Leu Ala Arg Ala Arg Arg Thr Asp
    50                  55                  60                  
Arg Trp Thr Ser Gly Leu Val Glu Met Ala Thr Leu Ser Leu Thr Val
65                  70                  75                  80  
Asn Ser Gly Asp Pro Pro Leu Gly Ala Leu Leu Ala Val Glu His Val
                85                  90                  95      
Lys Asp Asp Val Ser Ile Ser Val Glu Glu Gly Lys Glu Asn Ile Leu
            100                 105                 110         
His Val Ser Glu Asn Val Ile Phe Thr Asp Val Asn Ser Ile Leu Arg
        115                 120                 125             
Tyr Leu Ala Arg Val Ala Thr Thr Ala Gly Leu Tyr Gly Ser Asn Leu
    130                 135                 140                 
Met Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys
145                 150                 155                 160 
Leu Ser Ser Cys Asp Ser Phe Thr Ser Thr Ile Asn Glu Leu Asn His
                165                 170                 175     
Cys Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Ser Leu Ala
            180                 185                 190         
Asp Leu Cys Val Trp Ala Thr Leu Lys Gly Asn Ala Ala Trp Gln Glu
        195                 200                 205             
Gln Leu Lys Gln Lys Lys Ala Pro Val His Val Lys Arg Trp Phe Gly
    210                 215                 220                 
Phe Leu Glu Ala Gln Gln Ala Phe Gln Ser Val Gly Thr Lys Trp Asp
225                 230                 235                 240 
Val Ser Thr Thr Lys Ala Arg Val Ala Pro Glu Lys Lys Gln Asp Val
                245                 250                 255     
Gly Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val
            260                 265                 270         
Arg Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys
        275                 280                 285             
Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu
    290                 295                 300                 
Ile Met Arg Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe
305                 310                 315                 320 
Glu Lys Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp
                325                 330                 335     
Gln Phe Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala
            340                 345                 350         
Glu Lys Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala
        355                 360                 365             
Glu Gln Met Lys Ala Glu Arg Glu Gln Arg Ile Asp Ser Lys His Arg
    370                 375                 380                 
Lys Asn Pro Ile Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys
385                 390                 395                 400 
Gly Ser Gln Phe Gly Gln Ser Cys Cys Leu Arg Ala Lys Ile Asp Met
                405                 410                 415     
Ser Ser Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys
            420                 425                 430         
Ile Gln Pro His Pro Arg Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr
        435                 440                 445             
Tyr Asp Phe Ala Cys Pro Ile Val Asp Ser Ile Glu Gly Val Thr His
    450                 455                 460                 
Ala Leu Arg Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp
465                 470                 475                 480 
Ile Ile Glu Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser
                485                 490                 495     
Arg Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys Leu Thr Trp
            500                 505                 510         
Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro Arg Phe Pro
        515                 520                 525             
Thr Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys
    530                 535                 540                 
Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn Met Glu
545                 550                 555                 560 
Trp Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro Val Ala
                565                 570                 575     
Pro Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Ile Pro Val Asn Val
            580                 585                 590         
Pro Glu Ala Gln Glu Glu Met Lys Glu Val Ala Lys His Pro Lys Asn
        595                 600                 605             
Pro Glu Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys Val Phe Ile
    610                 615                 620                 
Glu Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met Val Thr Phe
625                 630                 635                 640 
Ile Asn Trp Gly Asn Leu Asn Ile Thr Lys Ile His Lys Asn Ala Asp
                645                 650                 655     
Gly Lys Ile Ile Ser Leu Asp Ala Lys Leu Asn Leu Glu Asn Lys Asp
            660                 665                 670         
Tyr Lys Lys Thr Thr Lys Val Thr Trp Leu Ala Glu Thr Thr His Ala
        675                 680                 685             
Leu Pro Ile Pro Val Ile Cys Val Thr Tyr Glu His Leu Ile Thr Lys
    690                 695                 700                 
Pro Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Val Asn Lys Asn
705                 710                 715                 720 
Ser Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu Lys Asp Leu
                725                 730                 735     
Lys Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg Gly Phe Phe Ile Cys
            740                 745                 750         
Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Lys Glu Ala Pro
        755                 760                 765             
Cys Val Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr
    770                 775                 780                 
Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ala Thr Lys Asn Glu Thr
785                 790                 795                 800 
Ser Ala Pro Phe Lys Glu Arg Pro Thr Pro Ser Leu Asn Asn Asn Cys
                805                 810                 815     
Thr Thr Ser Glu Asp Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln
            820                 825                 830         
Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp
        835                 840                 845             
Val Asp Ala Ala Val Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys
    850                 855                 860                 
Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile
865                 870                 875                 880 
Gly Gln Asn Ile Ser Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys
                885                 890                 895     
Ser Leu Tyr Asp Glu Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu
            900                 905                 910         
Lys Ala Glu Lys Ser Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys
        915                 920                 925             
Leu Leu Ser Leu Lys Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr
    930                 935                 940                 
Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr
945                 950                 955                 960 
Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu
                965                 970                 975     
Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr
            980                 985                 990         
Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu
        995                 1000                1005            
Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro
    1010                1015                1020                
Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys
1025                1030                1035                1040
Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly
                1045                1050                1055    
Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser
            1060                1065                1070        
Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu
        1075                1080                1085            
Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr Ser Gln Val Ile
    1090                1095                1100                
Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser Gly Cys Tyr Ile
1105                1110                1115                1120
Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile Lys Asp Phe Phe
                1125                1130                1135    
Asp Ala Glu Ile Lys Lys Leu Gly Val Glu Asn Cys Tyr Phe Pro Met
            1140                1145                1150        
Phe Val Ser Gln Ser Ala Leu Glu Lys Glu Lys Thr His Val Ala Asp
        1155                1160                1165            
Phe Ala Pro Glu Val Ala Trp Val Thr Arg Ser Gly Lys Thr Glu Leu
    1170                1175                1180                
Ala Glu Pro Ile Ala Ile Arg Pro Thr Ser Glu Thr Val Met Tyr Pro
1185                1190                1195                1200
Ala Tyr Ala Lys Trp Val Gln Ser His Arg Asp Leu Pro Ile Lys Leu
                1205                1210                1215    
Asn Gln Trp Cys Asn Val Val Arg Trp Glu Phe Lys His Pro Gln Pro
            1220                1225                1230        
Phe Leu Arg Thr Arg Glu Phe Leu Trp Gln Glu Gly His Ser Ala Phe
        1235                1240                1245            
Ala Thr Met Glu Glu Ala Ala Glu Glu Val Leu Gln Ile Leu Asp Leu
    1250                1255                1260                
Tyr Ala Gln Val Tyr Glu Glu Leu Leu Ala Ile Pro Val Val Lys Gly
1265                1270                1275                1280
Arg Lys Thr Glu Lys Glu Lys Phe Ala Gly Gly Asp Tyr Thr Thr Thr
                1285                1290                1295    
Ile Glu Ala Phe Ile Ser Ala Ser Gly Arg Ala Ile Gln Gly Gly Thr
            1300                1305                1310        
Ser His His Leu Gly Gln Asn Phe Ser Lys Met Phe Glu Ile Val Phe
        1315                1320                1325            
Glu Asp Pro Lys Ile Pro Gly Glu Lys Gln Phe Ala Tyr Gln Asn Ser
    1330                1335                1340                
Trp Gly Leu Thr Thr Arg Thr Ile Gly Val Met Thr Met Val His Gly
1345                1350                1355                1360
Asp Asn Met Gly Leu Val Leu Pro Pro Arg Val Ala Cys Val Gln Val
                1365                1370                1375    
Val Ile Ile Pro Cys Gly Ile Thr Asn Ala Leu Ser Glu Glu Asp Lys
            1380                1385                1390        
Glu Ala Leu Ile Ala Lys Cys Asn Asp Tyr Arg Arg Arg Leu Leu Ser
        1395                1400                1405            
Val Asn Ile Arg Val Arg Ala Asp Leu Arg Asp Asn Tyr Ser Pro Gly
    1410                1415                1420                
Trp Lys Phe Asn His Trp Glu Leu Lys Gly Val Pro Ile Arg Leu Glu
1425                1430                1435                1440
Val Gly Pro Arg Asp Met Lys Ser Cys Gln Phe Val Ala Val Arg Arg
                1445                1450                1455    
Asp Thr Gly Glu Lys Leu Thr Val Ala Glu Asn Glu Ala Glu Thr Lys
            1460                1465                1470        
Leu Gln Ala Ile Leu Glu Asp Ile Gln Val Thr Leu Phe Thr Arg Ala
        1475                1480                1485            
Ser Glu Asp Leu Lys Thr His Met Val Val Ala Asn Thr Met Glu Asp
    1490                1495                1500                
Phe Gln Lys Ile Leu Asp Ser Gly Lys Ile Val Gln Ile Pro Phe Cys
1505                1510                1515                1520
Gly Glu Ile Asp Cys Glu Asp Trp Ile Lys Lys Thr Thr Ala Arg Asp
                1525                1530                1535    
Gln Asp Leu Glu Pro Gly Ala Pro Ser Met Gly Ala Lys Ser Leu Cys
            1540                1545                1550        
Ile Pro Phe Lys Pro Leu Cys Glu Leu Gln Pro Gly Ala Lys Cys Val
        1555                1560                1565            
Cys Gly Lys Asn Pro Ala Lys Tyr Tyr Thr Leu Phe Gly Arg Ser Tyr
    1570                1575                1580                


<210> 7717
<211> 875
<212> PRT
<213> Homo sapiens

<400> 7717
Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe
 1               5                  10                  15      
Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg
            20                  25                  30          
Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu
        35                  40                  45              
Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu
    50                  55                  60                  
Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met
65                  70                  75                  80  
Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr
                85                  90                  95      
Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro
            100                 105                 110         
Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu
        115                 120                 125             
Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val
    130                 135                 140                 
Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp
145                 150                 155                 160 
Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys
                165                 170                 175     
Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys
            180                 185                 190         
Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys
        195                 200                 205             
Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe
    210                 215                 220                 
Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile
225                 230                 235                 240 
Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys
                245                 250                 255     
Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu
            260                 265                 270         
Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu
        275                 280                 285             
Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp
    290                 295                 300                 
Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser
305                 310                 315                 320 
Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu
                325                 330                 335     
Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg
            340                 345                 350         
Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser
        355                 360                 365             
Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu
    370                 375                 380                 
Glu Ala Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu Trp
385                 390                 395                 400 
Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro Leu
                405                 410                 415     
His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile Ser
            420                 425                 430         
Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met Arg
        435                 440                 445             
Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg Gly
    450                 455                 460                 
Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp Asn
465                 470                 475                 480 
Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val Asn
                485                 490                 495     
Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln His
            500                 505                 510         
Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile His
        515                 520                 525             
Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr Pro
    530                 535                 540                 
Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn Ile
545                 550                 555                 560 
Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu Leu
                565                 570                 575     
Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly Asn
            580                 585                 590         
Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val Leu
        595                 600                 605             
Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr Tyr
    610                 615                 620                 
Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys Gly
625                 630                 635                 640 
Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His Gly
                645                 650                 655     
Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro Leu
            660                 665                 670         
Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met Gly
        675                 680                 685             
Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn Thr
    690                 695                 700                 
Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys Lys
705                 710                 715                 720 
Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His Ala
                725                 730                 735     
Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn Phe
            740                 745                 750         
Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala Gln
        755                 760                 765             
Pro Pro Gly Pro Ala Gln Ile Leu Pro Pro Gly Leu Thr Pro Gly Leu
    770                 775                 780                 
Pro Tyr Pro His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln Pro
785                 790                 795                 800 
Arg Pro Pro Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val
                805                 810                 815     
Pro Thr Gly Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg
            820                 825                 830         
Gly Asn Tyr Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys Pro
        835                 840                 845             
Arg Asn Arg Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr Arg
    850                 855                 860                 
Asp Leu Asp Ala Pro Asp Asp Val Asp Phe Phe
865                 870                 875 


<210> 7718
<211> 796
<212> PRT
<213> Homo sapiens

<400> 7718
Met Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly
 1               5                  10                  15      
Tyr Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro
            20                  25                  30          
Pro Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val
        35                  40                  45              
Leu Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly
    50                  55                  60                  
Val Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu
65                  70                  75                  80  
Asp Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr
                85                  90                  95      
Lys Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His
            100                 105                 110         
Lys Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly
        115                 120                 125             
Lys Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val
    130                 135                 140                 
Phe Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp
145                 150                 155                 160 
Ile Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile
                165                 170                 175     
Lys Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu
            180                 185                 190         
Glu Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu
        195                 200                 205             
Glu Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn
    210                 215                 220                 
Asp Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser
225                 230                 235                 240 
Ser Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu
                245                 250                 255     
Glu Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys
            260                 265                 270         
Arg Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val
        275                 280                 285             
Ser Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys
    290                 295                 300                 
Glu Glu Ala Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu
305                 310                 315                 320 
Trp Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro
                325                 330                 335     
Leu His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile
            340                 345                 350         
Ser Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met
        355                 360                 365             
Arg Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg
    370                 375                 380                 
Gly Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp
385                 390                 395                 400 
Asn Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val
                405                 410                 415     
Asn Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln
            420                 425                 430         
His Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile
        435                 440                 445             
His Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr
    450                 455                 460                 
Pro Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn
465                 470                 475                 480 
Ile Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu
                485                 490                 495     
Leu Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly
            500                 505                 510         
Asn Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val
        515                 520                 525             
Leu Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr
    530                 535                 540                 
Tyr Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys
545                 550                 555                 560 
Gly Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His
                565                 570                 575     
Gly Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro
            580                 585                 590         
Leu Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met
        595                 600                 605             
Gly Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn
    610                 615                 620                 
Thr Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys
625                 630                 635                 640 
Lys Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His
                645                 650                 655     
Ala Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn
            660                 665                 670         
Phe Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala
        675                 680                 685             
Gln Pro Pro Gly Pro Ala Gln Ile Leu Pro Pro Gly Leu Thr Pro Gly
    690                 695                 700                 
Leu Pro Tyr Pro His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln
705                 710                 715                 720 
Pro Arg Pro Pro Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala
                725                 730                 735     
Val Pro Thr Gly Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly
            740                 745                 750         
Arg Gly Asn Tyr Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys
        755                 760                 765             
Pro Arg Asn Arg Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr
    770                 775                 780                 
Arg Asp Leu Asp Ala Pro Asp Asp Val Asp Phe Phe
785                 790                 795     


<210> 7719
<211> 872
<212> PRT
<213> Homo sapiens

<400> 7719
Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe
 1               5                  10                  15      
Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg
            20                  25                  30          
Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu
        35                  40                  45              
Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu
    50                  55                  60                  
Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met
65                  70                  75                  80  
Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr
                85                  90                  95      
Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro
            100                 105                 110         
Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu
        115                 120                 125             
Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val
    130                 135                 140                 
Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp
145                 150                 155                 160 
Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys
                165                 170                 175     
Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys
            180                 185                 190         
Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys
        195                 200                 205             
Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe
    210                 215                 220                 
Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile
225                 230                 235                 240 
Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys
                245                 250                 255     
Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu
            260                 265                 270         
Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu
        275                 280                 285             
Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp
    290                 295                 300                 
Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser
305                 310                 315                 320 
Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu
                325                 330                 335     
Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg
            340                 345                 350         
Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser
        355                 360                 365             
Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu
    370                 375                 380                 
Glu Ala Glu Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu
385                 390                 395                 400 
Trp Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro
                405                 410                 415     
Leu His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile
            420                 425                 430         
Ser Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met
        435                 440                 445             
Arg Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg
    450                 455                 460                 
Gly Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp
465                 470                 475                 480 
Asn Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val
                485                 490                 495     
Asn Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln
            500                 505                 510         
His Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile
        515                 520                 525             
His Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr
    530                 535                 540                 
Pro Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn
545                 550                 555                 560 
Ile Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu
                565                 570                 575     
Leu Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly
            580                 585                 590         
Asn Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val
        595                 600                 605             
Leu Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr
    610                 615                 620                 
Tyr Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys
625                 630                 635                 640 
Gly Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His
                645                 650                 655     
Gly Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro
            660                 665                 670         
Leu Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met
        675                 680                 685             
Gly Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn
    690                 695                 700                 
Thr Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys
705                 710                 715                 720 
Lys Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His
                725                 730                 735     
Ala Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn
            740                 745                 750         
Phe Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala
        755                 760                 765             
Gln Pro Pro Gly Pro Ala Gln Ser Leu Thr Pro Gly Leu Pro Tyr Pro
    770                 775                 780                 
His Gln Thr Pro Gln Gly Leu Met Pro Tyr Gly Gln Pro Arg Pro Pro
785                 790                 795                 800 
Ile Leu Gly Tyr Gly Ala Gly Ala Val Arg Pro Ala Val Pro Thr Gly
                805                 810                 815     
Gly Pro Pro Tyr Pro His Ala Pro Tyr Gly Ala Gly Arg Gly Asn Tyr
            820                 825                 830         
Asp Ala Phe Arg Gly Gln Gly Gly Tyr Pro Gly Lys Pro Arg Asn Arg
        835                 840                 845             
Met Val Arg Gly Asp Pro Arg Ala Ile Val Glu Tyr Arg Asp Leu Asp
    850                 855                 860                 
Ala Pro Asp Asp Val Asp Phe Phe
865                 870         


<210> 7720
<211> 884
<212> PRT
<213> Homo sapiens

<400> 7720
Met Gly Asp Ser Asp Asp Glu Tyr Asp Arg Arg Arg Arg Asp Lys Phe
 1               5                  10                  15      
Arg Arg Glu Arg Ser Asp Tyr Asp Arg Ser Arg Glu Arg Asp Glu Arg
            20                  25                  30          
Arg Arg Gly Asp Asp Trp Asn Asp Arg Glu Trp Asp Arg Gly Arg Glu
        35                  40                  45              
Arg Arg Ser Arg Gly Glu Tyr Arg Asp Tyr Asp Arg Asn Arg Arg Glu
    50                  55                  60                  
Arg Phe Ser Pro Pro Arg His Glu Leu Ser Pro Pro Gln Lys Arg Met
65                  70                  75                  80  
Arg Arg Asp Trp Asp Glu His Ser Ser Asp Pro Tyr His Ser Gly Tyr
                85                  90                  95      
Glu Met Pro Tyr Ala Gly Gly Gly Gly Gly Pro Thr Tyr Gly Pro Pro
            100                 105                 110         
Gln Pro Trp Gly His Pro Asp Val His Ile Met Gln His His Val Leu
        115                 120                 125             
Pro Ile Gln Ala Arg Leu Gly Ser Ile Ala Glu Ile Asp Leu Gly Val
    130                 135                 140                 
Pro Pro Pro Val Met Lys Thr Phe Lys Glu Phe Leu Leu Ser Leu Asp
145                 150                 155                 160 
Asp Ser Val Asp Glu Thr Glu Ala Val Lys Arg Tyr Asn Asp Tyr Lys
                165                 170                 175     
Leu Asp Phe Arg Arg Gln Gln Met Gln Asp Phe Phe Leu Ala His Lys
            180                 185                 190         
Asp Glu Glu Trp Phe Arg Ser Lys Tyr His Pro Asp Glu Val Gly Lys
        195                 200                 205             
Arg Arg Gln Glu Ala Arg Gly Ala Leu Gln Asn Arg Leu Arg Val Phe
    210                 215                 220                 
Leu Ser Leu Met Glu Thr Gly Trp Phe Asp Asn Leu Leu Leu Asp Ile
225                 230                 235                 240 
Asp Lys Ala Asp Ala Ile Val Lys Met Leu Asp Ala Ala Val Ile Lys
                245                 250                 255     
Met Glu Gly Gly Thr Glu Asn Asp Leu Arg Ile Leu Glu Gln Glu Glu
            260                 265                 270         
Glu Glu Glu Gln Ala Gly Lys Pro Gly Glu Pro Ser Lys Lys Glu Glu
        275                 280                 285             
Gly Arg Ala Gly Ala Gly Leu Gly Asp Gly Glu Arg Lys Thr Asn Asp
    290                 295                 300                 
Lys Asp Glu Lys Lys Glu Asp Gly Lys Gln Ala Glu Asn Asp Ser Ser
305                 310                 315                 320 
Asn Asp Asp Lys Thr Lys Lys Ser Glu Gly Asp Gly Asp Lys Glu Glu
                325                 330                 335     
Lys Lys Glu Asp Ser Glu Lys Glu Ala Lys Lys Ser Ser Lys Lys Arg
            340                 345                 350         
Asn Arg Lys His Ser Gly Asp Asp Ser Phe Asp Glu Gly Ser Val Ser
        355                 360                 365             
Glu Ser Glu Ser Glu Ser Glu Ser Gly Gln Ala Glu Glu Glu Lys Glu
    370                 375                 380                 
Glu Ala Glu Glu Ala Leu Lys Glu Lys Glu Lys Pro Lys Glu Glu Glu
385                 390                 395                 400 
Trp Glu Lys Pro Lys Asp Ala Ala Gly Leu Glu Cys Lys Pro Arg Pro
                405                 410                 415     
Leu His Lys Thr Cys Ser Leu Phe Met Arg Asn Ile Ala Pro Asn Ile
            420                 425                 430         
Ser Arg Ala Glu Ile Ile Ser Leu Cys Lys Arg Tyr Pro Gly Phe Met
        435                 440                 445             
Arg Val Ala Leu Ser Glu Pro Gln Pro Glu Arg Arg Phe Phe Arg Arg
    450                 455                 460                 
Gly Trp Val Thr Phe Asp Arg Ser Val Asn Ile Lys Glu Ile Cys Trp
465                 470                 475                 480 
Asn Leu Gln Asn Ile Arg Leu Arg Glu Cys Glu Leu Ser Pro Gly Val
                485                 490                 495     
Asn Arg Asp Leu Thr Arg Arg Val Arg Asn Ile Asn Gly Ile Thr Gln
            500                 505                 510         
His Lys Gln Ile Val Arg Asn Asp Ile Lys Leu Ala Ala Lys Leu Ile
        515                 520                 525             
His Thr Leu Asp Asp Arg Thr Gln Leu Trp Ala Ser Glu Pro Gly Thr
    530                 535                 540                 
Pro Pro Leu Pro Thr Ser Leu Pro Ser Gln Asn Pro Ile Leu Lys Asn
545                 550                 555                 560 
Ile Thr Asp Tyr Leu Ile Glu Glu Val Ser Ala Glu Glu Glu Glu Leu
                565                 570                 575     
Leu Gly Ser Ser Gly Gly Ala Pro Pro Glu Glu Pro Pro Lys Glu Gly
            580                 585                 590         
Asn Pro Ala Glu Ile Asn Val Glu Arg Asp Glu Lys Leu Ile Lys Val
        595                 600                 605             
Leu Asp Lys Leu Leu Leu Tyr Leu Arg Ile Val His Ser Leu Asp Tyr
    610                 615                 620                 
Tyr Asn Thr Cys Glu Tyr Pro Asn Glu Asp Glu Met Pro Asn Arg Cys
625                 630                 635                 640 
Gly Ile Ile His Val Arg Gly Pro Met Pro Pro Asn Arg Ile Ser His
                645                 650                 655     
Gly Glu Val Leu Glu Trp Gln Lys Thr Phe Glu Glu Lys Leu Thr Pro
            660                 665                 670         
Leu Leu Ser Val Arg Glu Ser Leu Ser Glu Glu Glu Ala Gln Lys Met
        675                 680                 685             
Gly Arg Lys Asp Pro Glu Gln Glu Val Glu Lys Phe Val Thr Ser Asn
    690                 695                 700                 
Thr Gln Glu Leu Gly Lys Asp Lys Trp Leu Cys Pro Leu Ser Gly Lys
705                 710                 715                 720 
Lys Phe Lys Gly Pro Glu Phe Val Arg Lys His Ile Phe Asn Lys His
                725                 730                 735     
Ala Glu Lys Ile Glu Glu Val Lys Lys Glu Val Ala Phe Phe Asn Asn
            740                 745                 750         
Phe Leu Thr Asp Ala Lys Arg Pro Ala Leu Pro Glu Ile Lys Pro Ala
        755                 760                 765             
Gln Pro Pro Gly Pro Ala Gln Ile Ile His Val Pro Val Arg Val Val
    770                 775                 780                 
Leu Pro Pro Gly Leu Thr Pro Gly Leu Pro Tyr Pro His Gln Thr Pro
785                 790                 795                 800 
Gln Gly Leu Met Pro Tyr Gly Gln Pro Arg Pro Pro Ile Leu Gly Tyr
                805                 810                 815     
Gly Ala Gly Ala Val Arg Pro Ala Val Pro Thr Gly Gly Pro Pro Tyr
            820                 825                 830         
Pro His Ala Pro Tyr Gly Ala Gly Arg Gly Asn Tyr Asp Ala Phe Arg
        835                 840                 845             
Gly Gln Gly Gly Tyr Pro Gly Lys Pro Arg Asn Arg Met Val Arg Gly
    850                 855                 860                 
Asp Pro Arg Ala Ile Val Glu Tyr Arg Asp Leu Asp Ala Pro Asp Asp
865                 870                 875                 880 
Val Asp Phe Phe
                


<210> 7721
<211> 399
<212> PRT
<213> Homo sapiens

<400> 7721
Val His Ser Ser Met Gly Ala Pro Glu Ile Arg Met Ser Lys Pro Leu
 1               5                  10                  15      
Glu Ala Glu Lys Gln Gly Leu Asp Ser Pro Ser Glu His Thr Asp Thr
            20                  25                  30          
Glu Arg Asn Gly Pro Asp Thr Asn His Gln Asn Pro Gln Asn Lys Thr
        35                  40                  45              
Ser Pro Phe Ser Val Ser Pro Thr Gly Pro Ser Thr Lys Ile Lys Ala
    50                  55                  60                  
Glu Asp Pro Ser Gly Asp Ser Ala Pro Ala Ala Pro Leu Pro Pro Gln
65                  70                  75                  80  
Pro Ala Gln Pro His Leu Pro Gln Ala Gln Leu Met Leu Thr Gly Ser
                85                  90                  95      
Gln Leu Ala Gly Asp Ile Gln Gln Leu Leu Gln Leu Gln Gln Leu Val
            100                 105                 110         
Leu Val Pro Gly His His Leu Gln Pro Pro Ala Gln Phe Leu Leu Pro
        115                 120                 125             
Gln Ala Gln Gln Ser Gln Pro Gly Leu Leu Pro Thr Pro Asn Leu Phe
    130                 135                 140                 
Gln Leu Pro Gln Gln Thr Gln Gly Ala Leu Leu Thr Ser Gln Pro Arg
145                 150                 155                 160 
Ala Gly Leu Pro Thr Gln Pro Pro Lys Cys Leu Glu Pro Pro Ser His
                165                 170                 175     
Pro Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala Arg Thr
            180                 185                 190         
Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp Val Gly
        195                 200                 205             
Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr Thr Ile
    210                 215                 220                 
Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys Lys Leu
225                 230                 235                 240 
Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu Thr Met Ser Val
                245                 250                 255     
Asp Ser Ser Leu Pro Ser Pro Asn Gln Leu Ser Ser Pro Ser Leu Gly
            260                 265                 270         
Phe Asp Gly Leu Pro Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu
        275                 280                 285             
Thr Asn Val Arg Phe Ala Leu Glu Lys Ser Phe Leu Ala Asn Gln Lys
    290                 295                 300                 
Pro Thr Ser Glu Glu Ile Leu Leu Ile Ala Glu Gln Leu His Met Glu
305                 310                 315                 320 
Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys
                325                 330                 335     
Arg Ile Asn Pro Cys Ser Ala Ala Pro Met Leu Pro Ser Pro Gly Lys
            340                 345                 350         
Pro Ala Ser Tyr Ser Pro His Met Val Thr Pro Gln Gly Gly Ala Gly
        355                 360                 365             
Thr Leu Pro Leu Ser Gln Ala Ser Ser Ser Leu Ser Thr Thr Ala Gln
    370                 375                 380                 
Thr Pro Ala Leu Lys Ala Ala Thr Arg Leu Ser Ala Cys Gln Ala
385                 390                 395                 


<210> 7722
<211> 754
<212> PRT
<213> Homo sapiens

<400> 7722
Met Trp Lys Leu Leu Pro Ala Ala Gly Pro Ala Gly Gly Glu Pro Tyr
 1               5                  10                  15      
Arg Leu Leu Thr Gly Val Glu Tyr Val Val Gly Arg Lys Asn Cys Ala
            20                  25                  30          
Ile Leu Ile Glu Asn Asp Gln Ser Ile Ser Arg Asn His Ala Val Leu
        35                  40                  45              
Thr Ala Asn Phe Ser Val Thr Asn Leu Ser Gln Thr Asp Glu Ile Pro
    50                  55                  60                  
Val Leu Thr Leu Lys Asp Asn Ser Lys Tyr Gly Thr Phe Val Asn Glu
65                  70                  75                  80  
Glu Lys Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly
                85                  90                  95      
Ile Thr Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro
            100                 105                 110         
Leu Val Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu
        115                 120                 125             
Asn Gln Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr
    130                 135                 140                 
Glu Glu Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys
145                 150                 155                 160 
Thr Ile Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr
                165                 170                 175     
Phe Thr Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln
            180                 185                 190         
Ile Glu Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys
        195                 200                 205             
Asn Val Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly
    210                 215                 220                 
Lys Thr Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser
225                 230                 235                 240 
Ala Val Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn
                245                 250                 255     
Glu Glu Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp
            260                 265                 270         
Thr Gly Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys
        275                 280                 285             
Trp Ile Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro
    290                 295                 300                 
Ile Pro Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys
305                 310                 315                 320 
Asn Tyr Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr
                325                 330                 335     
Thr Pro Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu
            340                 345                 350         
Met Pro Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu
        355                 360                 365             
Ser Glu Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile
    370                 375                 380                 
Lys Val Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala
385                 390                 395                 400 
Pro Thr Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met
                405                 410                 415     
Val Ser Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser
            420                 425                 430         
Pro Thr Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln
        435                 440                 445             
Gln Gln Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys
    450                 455                 460                 
Lys Arg Glu Arg Asp Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser
465                 470                 475                 480 
Ala Arg Ile Glu Thr Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala
                485                 490                 495     
Thr Pro Ser Leu Trp Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu
            500                 505                 510         
Pro Val Asp Thr Asn Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu
        515                 520                 525             
Lys Ser Ile Val Lys Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys
    530                 535                 540                 
Leu Arg Ser Asn Lys Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp
545                 550                 555                 560 
Glu Val Leu Glu Gln Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile
                565                 570                 575     
Asp Val Lys Val Gln Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg
            580                 585                 590         
Pro Arg Met Asp Ile Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val
        595                 600                 605             
Pro Glu Ser Ser Lys Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg
    610                 615                 620                 
Glu Leu Lys Glu Asp Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn
625                 630                 635                 640 
Asp Lys Leu Gln Asp Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu
                645                 650                 655     
Thr Glu Phe Arg Ser Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro
            660                 665                 670         
Ser Gly Ile Asn Asp Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe
        675                 680                 685             
Lys Lys Val Thr Tyr Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly
    690                 695                 700                 
Gly Ser Asp Leu Ile Ala His His Ala Arg Lys Asn Thr Glu Leu Glu
705                 710                 715                 720 
Glu Trp Leu Arg Gln Glu Met Glu Val Gln Asn Gln His Ala Lys Glu
                725                 730                 735     
Glu Ser Leu Ala Asp Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg
            740                 745                 750         
Arg Arg
        


<210> 7723
<211> 902
<212> PRT
<213> Homo sapiens

<400> 7723
Phe Pro Met Gly Asp Ser Gly Ser Arg Arg Ser Thr Leu Val Ser Arg
 1               5                  10                  15      
Leu Pro Ile Phe Arg Arg Ser Ile Asn Arg Arg His Asp Ser Leu Pro
            20                  25                  30          
Ser Ser Pro Ser Ser Ser Asn Thr Val Gly Val His Ser Ser Ser Pro
        35                  40                  45              
Ser Ser Thr Asn Ser Ser Ser Gly Ser Thr Gly Lys Arg Arg Ser Ile
    50                  55                  60                  
Phe Arg Thr Pro Ser Ile Ser Phe His His Lys Lys Gly Ser Glu Pro
65                  70                  75                  80  
Lys Gln Glu Pro Thr Asn Gln Asn Leu Ser Ile Ser Asn Gly Ala Gln
                85                  90                  95      
Pro Gly His Ser Asn Met Gln Lys Leu Ser Leu Glu Glu His Ile Lys
            100                 105                 110         
Thr Arg Gly Arg His Ser Val Gly Phe Ser Ser Ser Arg Asn Lys Lys
        115                 120                 125             
Ile Thr Arg Ser Leu Thr Glu Asp Phe Glu Arg Glu Lys Glu His Ser
    130                 135                 140                 
Thr Asn Lys Asn Val Phe Ile Asn Cys Leu Ser Ser Gly Lys Ser Glu
145                 150                 155                 160 
Gly Asp Asp Ser Gly Phe Thr Glu Asp Gln Thr Arg Arg Ser Val Lys
                165                 170                 175     
Gln Ser Thr Arg Lys Leu Leu Pro Lys Ser Phe Ser Ser His Tyr Lys
            180                 185                 190         
Phe Ser Lys Pro Val Leu Gln Ser Gln Ser Ile Ser Leu Val Gln Gln
        195                 200                 205             
Ser Glu Phe Ser Leu Glu Val Thr Gln Tyr Gln Glu Arg Glu Pro Val
    210                 215                 220                 
Leu Val Arg Ala Ser Pro Ser Cys Ser Val Asp Val Thr Glu Arg Ala
225                 230                 235                 240 
Gly Ser Ser Leu Gln Ser Pro Leu Leu Ser Ala Asp Leu Thr Thr Ala
                245                 250                 255     
Gln Thr Pro Ser Glu Phe Leu Ala Leu Thr Glu Asp Ser Val Ser Glu
            260                 265                 270         
Met Asp Ala Phe Ser Lys Ser Gly Ser Met Ala Ser His Cys Asp Asn
        275                 280                 285             
Phe Gly His Asn Asp Ser Thr Ser Gln Met Ser Leu Asn Ser Ala Ala
    290                 295                 300                 
Val Thr Lys Thr Thr Thr Glu Leu Thr Gly Thr Val Pro Cys Ala Ile
305                 310                 315                 320 
Met Ser Pro Gly Lys Tyr Arg Leu Glu Gly Gln Cys Ser Thr Glu Ser
                325                 330                 335     
Asn Ser Leu Pro Glu Thr Ser Ala Ala Asn Gln Lys Glu Val Leu Leu
            340                 345                 350         
Gln Ile Ala Glu Leu Pro Ala Thr Ser Val Ser His Ser Glu Ser Asn
        355                 360                 365             
Leu Pro Ala Asp Ser Glu Arg Glu Glu Asn Ile Gly Leu Gln Asn Gly
    370                 375                 380                 
Glu Thr Met Leu Gly Thr Asn Ser Pro Arg Lys Leu Gly Phe Tyr Glu
385                 390                 395                 400 
Gln His Lys Ala Ile Ala Glu His Val Lys Gly Ile His Pro Ile Ser
                405                 410                 415     
Asp Ser Lys Ile Ile Pro Thr Ser Gly Asp His His Ile Phe Asn Lys
            420                 425                 430         
Thr Ser His Gly Tyr Glu Ala Asn Pro Ala Lys Val Leu Ala Ser Ser
        435                 440                 445             
Leu Ser Pro Phe Arg Glu Gly Arg Phe Ile Glu Arg Arg Leu Arg Ser
    450                 455                 460                 
Ser Ser Glu Gly Thr Ala Gly Ser Ser Arg Met Ile Leu Lys Pro Lys
465                 470                 475                 480 
Asp Gly Asn Ile Glu Glu Val Asn Ser Leu Arg Lys Gln Arg Ala Gly
                485                 490                 495     
Ser Ser Ser Ser Lys Met Asn Ser Leu Asp Val Leu Asn Asn Leu Gly
            500                 505                 510         
Ser Cys Glu Leu Asp Glu Asp Asp Leu Met Leu Asp Leu Glu Phe Leu
        515                 520                 525             
Glu Glu Gln Ser Leu His Pro Ser Val Cys Arg Glu Asp Ser Tyr His
    530                 535                 540                 
Ser Val Val Ser Cys Ala Ala Val Val Leu Thr Pro Met Glu Pro Met
545                 550                 555                 560 
Ile Glu Met Lys Lys Arg Glu Glu Pro Glu Phe Pro Glu Pro Ser Lys
                565                 570                 575     
Gln Asn Leu Ser Leu Lys Leu Thr Lys Asp Val Asp Gln Glu Ala Arg
            580                 585                 590         
Cys Ser His Ile Ser Arg Met Pro Asn Ser Pro Ser Ala Asp Trp Pro
        595                 600                 605             
Leu Gln Gly Val Glu Glu Asn Gly Gly Ile Asp Ser Leu Pro Phe Arg
    610                 615                 620                 
Leu Met Leu Gln Asp Cys Thr Ala Val Lys Thr Leu Leu Leu Lys Met
625                 630                 635                 640 
Lys Arg Val Leu Gln Glu Ser Ala Asp Met Ser Pro Ala Ser Ser Thr
                645                 650                 655     
Thr Ser Leu Pro Val Ser Pro Leu Thr Glu Glu Pro Val Pro Phe Lys
            660                 665                 670         
Asp Ile Met Lys Asp Glu Cys Ser Met Leu Lys Leu Gln Leu Lys Glu
        675                 680                 685             
Lys Asp Glu Leu Ile Ser Gln Leu Gln Glu Glu Leu Gly Lys Val Arg
    690                 695                 700                 
His Leu Gln Lys Ala Phe Ala Ser Arg Val Asp Lys Ser Thr Gln Thr
705                 710                 715                 720 
Glu Leu Leu Cys Tyr Asp Gly Leu Asn Leu Lys Arg Leu Glu Thr Val
                725                 730                 735     
Gln Gly Gly Arg Glu Ala Thr Tyr Arg Asn Arg Ile Val Ser Gln Asn
            740                 745                 750         
Leu Ser Thr Arg Asp Arg Lys Ala Ile His Thr Pro Thr Glu Asp Arg
        755                 760                 765             
Phe Arg Tyr Ser Ala Ala Asp Gln Thr Ser Pro Tyr Lys Asn Lys Thr
    770                 775                 780                 
Cys Gln Leu Pro Ser Leu Cys Leu Ser Asn Phe Leu Lys Asp Lys Glu
785                 790                 795                 800 
Leu Ala Glu Val Ile Lys His Ser Arg Gly Thr Tyr Glu Thr Leu Thr
                805                 810                 815     
Ser Asp Val Thr Gln Asn Leu Arg Ala Thr Val Gly Gln Ser Ser Leu
            820                 825                 830         
Lys Pro Thr Ala Lys Thr Glu Gly Leu Ser Thr Phe Leu Glu Lys Pro
        835                 840                 845             
Lys Asp Gln Val Ala Thr Ala Arg Gln His Ser Thr Phe Thr Gly Arg
    850                 855                 860                 
Phe Gly Gln Pro Pro Arg Gly Pro Ile Ser Leu His Met Tyr Ser Arg
865                 870                 875                 880 
Lys Asn Val Phe Leu His His Asn Leu His Ser Thr Glu Leu Gln Thr
                885                 890                 895     
Leu Gly Gln Gln Asp Gly
            900         


<210> 7724
<211> 872
<212> PRT
<213> Homo sapiens

<400> 7724
Met Gly Lys Lys Ile Lys Lys Glu Val Glu Pro Pro Pro Lys Asp Val
 1               5                  10                  15      
Phe Asp Pro Leu Met Ile Glu Ser Lys Lys Ala Ala Thr Val Val Leu
            20                  25                  30          
Met Leu Asn Ser Pro Glu Glu Glu Ile Leu Ala Lys Ala Cys Glu Ala
        35                  40                  45              
Ile Tyr Lys Phe Ala Leu Lys Gly Glu Glu Asn Lys Thr Thr Leu Leu
    50                  55                  60                  
Glu Leu Gly Ala Val Glu Pro Leu Thr Lys Leu Leu Thr His Glu Asp
65                  70                  75                  80  
Lys Ile Val Arg Arg Asn Ala Thr Met Ile Phe Gly Ile Leu Ala Ser
                85                  90                  95      
Asn Asn Asp Val Lys Lys Leu Leu Arg Glu Leu Asp Val Met Asn Ser
            100                 105                 110         
Val Ile Ala Gln Leu Ala Pro Glu Glu Glu Val Val Ile His Glu Phe
        115                 120                 125             
Ala Ser Leu Cys Leu Ala Asn Met Ser Ala Glu Tyr Thr Ser Lys Val
    130                 135                 140                 
Gln Ile Phe Glu His Gly Gly Leu Glu Pro Leu Ile Arg Leu Leu Ser
145                 150                 155                 160 
Ser Pro Asp Pro Asp Val Lys Lys Asn Ser Met Glu Cys Ile Tyr Asn
                165                 170                 175     
Leu Val Gln Asp Phe Gln Cys Arg Ala Lys Leu Gln Glu Leu Asn Ala
            180                 185                 190         
Ile Pro Pro Ile Leu Asp Leu Leu Lys Ser Glu Tyr Pro Val Ile Gln
        195                 200                 205             
Leu Leu Ala Leu Lys Thr Leu Gly Val Ile Ala Asn Asp Lys Glu Ser
    210                 215                 220                 
Arg Thr Met Leu Arg Asp Asn Gln Gly Leu Asp His Leu Ile Lys Ile
225                 230                 235                 240 
Leu Glu Thr Lys Glu Leu Asn Asp Leu His Ile Glu Ala Leu Ala Val
                245                 250                 255     
Ile Ala Asn Cys Leu Glu Asp Met Asp Thr Met Val Gln Ile Gln Gln
            260                 265                 270         
Thr Gly Gly Leu Lys Lys Leu Leu Ser Phe Ala Glu Asn Ser Thr Ile
        275                 280                 285             
Pro Asp Ile Gln Lys Asn Ala Ala Lys Ala Ile Thr Lys Ala Ala Tyr
    290                 295                 300                 
Asp Pro Glu Asn Arg Lys Leu Phe His Glu Gln Glu Val Glu Lys Cys
305                 310                 315                 320 
Leu Val Ala Leu Leu Gly Ser Glu Asn Asp Gly Thr Lys Ile Ala Ala
                325                 330                 335     
Ser Gln Ala Ile Ser Ala Met Cys Glu Asn Ser Gly Ser Lys Asp Phe
            340                 345                 350         
Phe Asn Asn Gln Gly Ile Pro Gln Leu Ile Gln Leu Leu Lys Ser Asp
        355                 360                 365             
Asn Glu Glu Val Arg Glu Ala Ala Ala Leu Ala Leu Ala Asn Leu Thr
    370                 375                 380                 
Thr Cys Asn Pro Ala Asn Ala Asn Ala Ala Ala Glu Ala Asp Gly Ile
385                 390                 395                 400 
Asp Pro Leu Ile Asn Leu Leu Ser Ser Lys Arg Asp Gly Ala Ile Ala
                405                 410                 415     
Asn Ala Ala Thr Val Leu Thr Asn Met Ala Met Gln Glu Pro Leu Arg
            420                 425                 430         
Leu Asn Ile Gln Asn His Asp Ile Met His Ala Ile Ile Ser Pro Leu
        435                 440                 445             
Arg Ser Ala Asn Thr Val Val Gln Ser Lys Ala Ala Leu Ala Val Thr
    450                 455                 460                 
Ala Thr Ala Cys Asp Val Glu Ala Arg Thr Glu Leu Arg Asn Ser Gly
465                 470                 475                 480 
Gly Leu Glu Pro Leu Val Glu Leu Leu Arg Ser Lys Asn Asp Glu Val
                485                 490                 495     
Arg Lys His Ala Ser Trp Ala Val Met Val Cys Ala Gly Asp Glu Leu
            500                 505                 510         
Thr Ala Asn Glu Leu Cys Arg Leu Gly Ala Leu Asp Ile Leu Glu Glu
        515                 520                 525             
Val Asn Val Ser Gly Thr Arg Lys Asn Lys Phe Ser Glu Ala Ala Tyr
    530                 535                 540                 
Asn Lys Leu Leu Asn Asn Asn Leu Ser Leu Lys Tyr Ser Gln Thr Gly
545                 550                 555                 560 
Tyr Leu Ser Ser Ser Asn Ile Ile Asn Asp Gly Phe Tyr Asp Tyr Gly
                565                 570                 575     
Arg Ile Asn Pro Gly Thr Lys Leu Leu Pro Leu Lys Glu Leu Cys Leu
            580                 585                 590         
Gln Glu Pro Ser Asp Leu Arg Ala Val Leu Leu Ile Asn Ser Lys Ser
        595                 600                 605             
Tyr Val Ser Pro Pro Ser Ser Met Glu Asp Lys Ser Asp Val Gly Tyr
    610                 615                 620                 
Gly Gln Ser Ile Ser Ser Ser Ser Ser Leu Arg Arg Ser Ser Lys Glu
625                 630                 635                 640 
Lys Asn Lys Lys Asn Ser Tyr His Phe Ser Ala Gly Phe Gly Ser Pro
                645                 650                 655     
Ile Glu Asp Lys Ser Glu Pro Ala Ser Gly Arg Asn Thr Val Leu Ser
            660                 665                 670         
Lys Ser Ala Thr Lys Glu Lys Gly Trp Arg Lys Ser Lys Gly Lys Lys
        675                 680                 685             
Glu Glu Glu Lys Val Lys Glu Glu Glu Glu Val Met Val Val Pro Lys
    690                 695                 700                 
Phe Val Gly Glu Gly Ser Ser Asp Lys Glu Trp Cys Pro Pro Ser Asp
705                 710                 715                 720 
Pro Asp Phe Ser Met Tyr Val Tyr Glu Val Thr Lys Ser Ile Leu Pro
                725                 730                 735     
Ile Thr Asn Ile Lys Glu Gln Ile Glu Asp Leu Ala Lys Tyr Val Ala
            740                 745                 750         
Glu Lys Met Gly Gly Lys Ile Pro Lys Glu Lys Leu Pro Asp Phe Ser
        755                 760                 765             
Trp Glu Leu His Ile Ser Glu Leu Lys Phe Gln Leu Lys Ser Asn Val
    770                 775                 780                 
Ile Pro Ile Gly His Val Lys Lys Gly Ile Phe Tyr His Arg Ala Leu
785                 790                 795                 800 
Leu Phe Lys Ala Leu Ala Asp Arg Ile Gly Ile Gly Cys Ser Leu Val
                805                 810                 815     
Arg Gly Glu Tyr Gly Arg Ala Trp Asn Glu Val Met Leu Gln Asn Asp
            820                 825                 830         
Ser Arg Lys Gly Val Ile Gly Gly Leu Pro Ala Pro Glu Met Tyr Val
        835                 840                 845             
Ile Asp Leu Met Phe His Pro Gly Gly Leu Met Lys Leu Arg Ser Arg
    850                 855                 860                 
Glu Ala Asp Leu Tyr Arg Phe Ile
865                 870         


<210> 7725
<211> 116
<212> PRT
<213> Homo sapiens

<400> 7725
Met Ala Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly Ser Gly Asn
 1               5                  10                  15      
Phe Gly Gly Gly Arg Gly Gly Gly Phe Ser Gly Asn Asp Asn Phe Gly
            20                  25                  30          
Ile Gly Gly Asn Phe Ser Gly Leu Gly Gly Phe Gly Gly Ser Arg Gly
        35                  40                  45              
Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Cys Asn Gly Phe Gly Asn
    50                  55                  60                  
Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn
65                  70                  75                  80  
Tyr Asn Asn Glu Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe
                85                  90                  95      
Gly Gly Arg Ser Ser Gly Pro Cys Gly Asn Gly Gly Leu Tyr Phe Ala
            100                 105                 110         
Lys Pro Arg Phe
        115     


<210> 7726
<211> 114
<212> PRT
<213> Homo sapiens

<400> 7726
Met Ala Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly Ser Gly Asn
 1               5                  10                  15      
Phe Gly Gly Gly Arg Gly Gly Gly Phe Ser Gly Asn Asp Asn Phe Gly
            20                  25                  30          
Ile Gly Gly Asn Phe Ser Gly Leu Gly Gly Phe Gly Gly Ser Arg Gly
        35                  40                  45              
Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Cys Asn Gly Phe Gly Asn
    50                  55                  60                  
Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn
65                  70                  75                  80  
Tyr Asn Asn Glu Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe
                85                  90                  95      
Gly Gly Arg Ser Ser Gly Pro Cys Gly Asn Gly Gly Leu Tyr Phe Ala
            100                 105                 110         
Lys Pro
        


<210> 7727
<211> 721
<212> PRT
<213> Homo sapiens

<400> 7727
Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe Arg Glu
 1               5                  10                  15      
Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys Ala Arg
            20                  25                  30          
Thr Ile Ala Val Gln Thr Pro Asp Gly Gly Ser Ala Ala Gly Gly Leu
        35                  40                  45              
Gly Gly Gly Ala Gly Gly Gly Gly Asp His Ala Asp Lys Leu Ser Leu
    50                  55                  60                  
Tyr Ser Glu Thr Asp Ser Gly Tyr Gly Ser Tyr Thr Pro Ser Leu Lys
65                  70                  75                  80  
Ser Pro Asn Gly Val Arg Val Leu Pro Met Val Pro Ala Pro Pro Gly
                85                  90                  95      
Ser Ser Ala Ala Ala Ala Arg Gly Ala Ala Cys Ser Ser Leu Ser Ser
            100                 105                 110         
Ser Ser Ser Ser Ile Thr Cys Pro Gln Cys His Arg Ser Ala Ser Leu
        115                 120                 125             
Asp His Arg Gly Leu Arg Gly Phe Gln Arg Asn Arg Leu Leu Glu Ala
    130                 135                 140                 
Ile Val Gln Arg Tyr Gln Gln Gly Arg Gly Ala Val Pro Gly Thr Ser
145                 150                 155                 160 
Ala Ala Ala Ala Val Ala Ile Cys Gln Leu Cys Asp Arg Thr Pro Pro
                165                 170                 175     
Glu Pro Ala Ala Thr Leu Cys Glu Gln Cys Asp Val Leu Tyr Cys Ser
            180                 185                 190         
Ala Cys Gln Leu Lys Cys His Pro Ser Arg Gly Pro Phe Ala Lys His
        195                 200                 205             
Arg Leu Gly Ala Pro Ser Gly Gly Gly Gly Cys Lys Ser Pro Gly Gly
    210                 215                 220                 
Ala Gly Ala Gly Ala Thr Gly Gly Ser Thr Ala Arg Lys Phe Pro Thr
225                 230                 235                 240 
Cys Pro Glu His Glu Met Glu Asn Tyr Ser Met Tyr Cys Val Ser Cys
                245                 250                 255     
Arg Thr Pro Val Cys Tyr Leu Cys Leu Glu Glu Gly Arg His Ala Lys
            260                 265                 270         
His Glu Val Lys Pro Leu Gly Ala Met Trp Lys Gln His Lys Ala Gln
        275                 280                 285             
Leu Ser Gln Ala Leu Asn Gly Val Ser Asp Lys Ala Lys Glu Ala Lys
    290                 295                 300                 
Glu Phe Leu Val Gln Leu Lys Asn Ile Leu Gln Gln Ile Gln Glu Asn
305                 310                 315                 320 
Gly Leu Asp Tyr Glu Ala Cys Leu Val Ala Gln Cys Asp Ala Leu Val
                325                 330                 335     
Asp Ala Leu Thr Arg Gln Lys Ala Lys Leu Leu Thr Lys Val Thr Lys
            340                 345                 350         
Glu Arg Glu His Lys Leu Lys Met Val Trp Asp Gln Ile Asn His Cys
        355                 360                 365             
Thr Leu Lys Leu Arg Gln Ser Thr Gly Leu Met Glu Tyr Cys Leu Glu
    370                 375                 380                 
Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln Ile Ser Asp Ala
385                 390                 395                 400 
Leu Ile Lys Arg Val Gln Val Ser Gln Glu Gln Trp Val Lys Gly Ala
                405                 410                 415     
Leu Glu Pro Lys Val Ser Ala Glu Phe Asp Leu Thr Leu Asp Ser Glu
            420                 425                 430         
Pro Leu Leu Gln Ala Ile His Gln Leu Asp Phe Ile Gln Met Lys Cys
        435                 440                 445             
Arg Val Pro Pro Val Pro Leu Leu Gln Leu Glu Lys Cys Cys Thr Arg
    450                 455                 460                 
Asn Asn Ser Val Thr Leu Ala Trp Arg Met Pro Pro Phe Thr His Ser
465                 470                 475                 480 
Pro Val Asp Gly Tyr Ile Leu Glu Leu Asp Asp Gly Ala Gly Gly Gln
                485                 490                 495     
Phe Arg Glu Val Tyr Val Gly Lys Glu Thr Leu Cys Thr Ile Asp Gly
            500                 505                 510         
Leu His Phe Asn Ser Thr Tyr Asn Ala Arg Val Lys Ala Phe Asn Ser
        515                 520                 525             
Ser Gly Val Gly Pro Tyr Ser Lys Thr Val Val Leu Gln Thr Ser Asp
    530                 535                 540                 
Val Ala Trp Phe Thr Phe Asp Pro Asn Ser Gly His Arg Asp Ile Ile
545                 550                 555                 560 
Leu Ser Asn Asp Asn Gln Thr Ala Thr Cys Ser Ser Tyr Asp Asp Arg
                565                 570                 575     
Val Val Leu Gly Thr Ala Ala Phe Ser Lys Gly Val His Tyr Trp Glu
            580                 585                 590         
Leu His Val Asp Arg Tyr Asp Asn His Pro Asp Pro Ala Phe Gly Val
        595                 600                 605             
Ala Arg Ala Ser Val Val Lys Asp Met Met Leu Gly Lys Asp Asp Lys
    610                 615                 620                 
Ala Trp Ala Met Tyr Val Asp Asn Asn Arg Ser Trp Phe Met His Cys
625                 630                 635                 640 
Asn Ser His Thr Asn Arg Thr Glu Gly Gly Val Cys Lys Gly Ala Thr
                645                 650                 655     
Val Gly Val Leu Leu Asp Leu Asn Lys His Thr Leu Thr Phe Phe Ile
            660                 665                 670         
Asn Gly Gln Gln Gln Gly Pro Thr Ala Phe Ser His Val Asp Gly Val
        675                 680                 685             
Phe Met Pro Ala Leu Ser Leu Asn Arg Asn Val Gln Val Thr Leu His
    690                 695                 700                 
Thr Gly Leu Glu Val Pro Thr Asn Leu Gly Arg Pro Lys Leu Ser Gly
705                 710                 715                 720 
Asn
    


<210> 7728
<211> 727
<212> PRT
<213> Homo sapiens

<400> 7728
Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe Arg Glu
 1               5                  10                  15      
Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys Ala Arg
            20                  25                  30          
Thr Ile Ala Val Gln Thr Pro Asp Gly Glu Gln His Leu Pro Gln Pro
        35                  40                  45              
Leu Leu Leu Ser Arg Gly Ser Gly Leu Gln Ala Gly Ala Ala Ala Ala
    50                  55                  60                  
Ala Ser Leu Glu His Asp Ala Ala Ala Gly Pro Ala Cys Gly Gly Ala
65                  70                  75                  80  
Gly Gly Ser Ala Ala Gly Gly Leu Gly Gly Gly Ala Gly Gly Gly Gly
                85                  90                  95      
Asp His Ala Asp Lys Leu Ser Leu Tyr Ser Glu Thr Asp Ser Gly Tyr
            100                 105                 110         
Gly Ser Tyr Thr Pro Ser Leu Lys Ser Pro Asn Gly Val Arg Val Leu
        115                 120                 125             
Pro Met Val Pro Ala Pro Pro Gly Ser Ser Ala Ala Ala Ala Arg Gly
    130                 135                 140                 
Ala Ala Cys Ser Ser Leu Ser Ser Ser Ser Ser Ser Ile Thr Cys Pro
145                 150                 155                 160 
Gln Cys His Arg Ser Ala Ser Leu Asp His Arg Gly Leu Arg Gly Phe
                165                 170                 175     
Gln Arg Asn Arg Leu Leu Glu Ala Ile Val Gln Arg Tyr Gln Gln Gly
            180                 185                 190         
Arg Gly Ala Val Pro Gly Thr Ser Ala Ala Ala Ala Val Ala Ile Cys
        195                 200                 205             
Gln Leu Cys Asp Arg Thr Pro Pro Glu Pro Ala Ala Thr Leu Cys Glu
    210                 215                 220                 
Gln Cys Asp Val Leu Tyr Cys Ser Ala Cys Gln Leu Lys Cys His Pro
225                 230                 235                 240 
Ser Arg Gly Pro Phe Ala Lys His Arg Leu Gly Ala Pro Ser Gly Gly
                245                 250                 255     
Gly Gly Cys Lys Ser Pro Gly Gly Ala Gly Ala Gly Ala Thr Gly Gly
            260                 265                 270         
Ser Thr Ala Arg Lys Phe Pro Thr Cys Pro Glu His Glu Met Glu Asn
        275                 280                 285             
Tyr Ser Met Tyr Cys Val Ser Cys Arg Thr Pro Val Cys Tyr Leu Cys
    290                 295                 300                 
Leu Glu Glu Gly Arg His Ala Lys His Glu Val Lys Pro Leu Gly Ala
305                 310                 315                 320 
Met Trp Lys Gln His Lys Ala Gln Leu Ser Gln Ala Leu Asn Gly Val
                325                 330                 335     
Ser Asp Lys Ala Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Lys Asn
            340                 345                 350         
Ile Leu Gln Gln Ile Gln Phe Ser Asp Ser Cys Gly Gly Leu Pro Val
        355                 360                 365             
Leu Pro Leu Met Arg Gln Leu Leu Arg Gly Val Phe Pro Leu Gln Met
    370                 375                 380                 
Val Trp Asp Gln Ile Asn His Cys Thr Leu Lys Leu Arg Gln Ser Thr
385                 390                 395                 400 
Gly Leu Met Glu Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser
                405                 410                 415     
Gly Phe Leu Gln Ile Ser Asp Ala Leu Ile Lys Arg Val Gln Val Ser
            420                 425                 430         
Gln Glu Gln Trp Val Lys Gly Ala Leu Glu Pro Lys Val Ser Ala Glu
        435                 440                 445             
Phe Asp Leu Thr Leu Asp Ser Glu Pro Leu Leu Gln Ala Ile His Gln
    450                 455                 460                 
Leu Asp Phe Ile Gln Met Lys Cys Arg Val Pro Pro Val Pro Leu Leu
465                 470                 475                 480 
Gln Leu Glu Lys Cys Cys Thr Arg Asn Asn Ser Val Thr Leu Ala Trp
                485                 490                 495     
Arg Met Pro Pro Phe Thr His Ser Pro Val Asp Gly Tyr Ile Leu Glu
            500                 505                 510         
Leu Asp Asp Gly Ala Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys
        515                 520                 525             
Glu Thr Leu Cys Thr Ile Asp Gly Leu His Phe Asn Ser Thr Tyr Asn
    530                 535                 540                 
Ala Arg Val Lys Ala Phe Asn Ser Ser Gly Val Gly Pro Tyr Ser Lys
545                 550                 555                 560 
Thr Val Val Leu Gln Thr Ser Asp Val Ala Trp Phe Thr Phe Asp Pro
                565                 570                 575     
Asn Ser Gly His Arg Asp Ile Ile Leu Ser Asn Asp Asn Gln Thr Ala
            580                 585                 590         
Thr Cys Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Thr Ala Ala Phe
        595                 600                 605             
Ser Lys Gly Val His Tyr Trp Glu Leu His Val Asp Arg Tyr Asp Asn
    610                 615                 620                 
His Pro Asp Pro Ala Phe Gly Val Ala Arg Ala Ser Val Val Lys Asp
625                 630                 635                 640 
Met Met Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn
                645                 650                 655     
Asn Arg Ser Trp Phe Met His Cys Asn Ser His Thr Asn Arg Thr Glu
            660                 665                 670         
Gly Gly Val Cys Lys Gly Ala Thr Val Gly Val Leu Leu Asp Leu Asn
        675                 680                 685             
Lys His Thr Leu Thr Phe Phe Ile Asn Gly Gln Gln Gln Gly Pro Thr
    690                 695                 700                 
Ala Phe Ser His Val Asp Gly Val Phe Met Pro Ala Leu Ser Leu Asn
705                 710                 715                 720 
Arg Asn Val Gln Val His Thr
                725         


<210> 7729
<211> 729
<212> PRT
<213> Homo sapiens

<400> 7729
Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Leu Phe Arg Glu
 1               5                  10                  15      
Pro Ile Ile Leu Pro Cys Ser His Asn Val Cys Leu Pro Cys Ala Arg
            20                  25                  30          
Thr Ile Ala Val Gln Thr Pro Asp Gly Glu Gln His Leu Pro Gln Pro
        35                  40                  45              
Leu Leu Leu Ser Arg Gly Ser Gly Leu Gln Ala Gly Ala Ala Ala Ala
    50                  55                  60                  
Ala Ser Leu Glu His Asp Ala Ala Ala Gly Pro Ala Cys Gly Gly Ala
65                  70                  75                  80  
Gly Gly Ser Ala Ala Gly Gly Leu Gly Gly Gly Ala Gly Gly Gly Gly
                85                  90                  95      
Asp His Ala Asp Lys Leu Ser Leu Tyr Ser Glu Thr Asp Ser Gly Tyr
            100                 105                 110         
Gly Ser Tyr Thr Pro Ser Leu Lys Ser Pro Asn Gly Val Arg Val Leu
        115                 120                 125             
Pro Met Val Pro Ala Pro Pro Gly Ser Ser Ala Ala Ala Ala Arg Gly
    130                 135                 140                 
Ala Ala Cys Ser Ser Leu Ser Ser Ser Ser Ser Ser Ile Thr Cys Pro
145                 150                 155                 160 
Gln Cys His Arg Ser Ala Ser Leu Asp His Arg Gly Leu Arg Gly Phe
                165                 170                 175     
Gln Arg Asn Arg Leu Leu Glu Ala Ile Val Gln Arg Tyr Gln Gln Gly
            180                 185                 190         
Arg Gly Ala Val Pro Gly Thr Ser Ala Ala Ala Ala Val Ala Ile Cys
        195                 200                 205             
Gln Leu Cys Asp Arg Thr Pro Pro Glu Pro Ala Ala Thr Leu Cys Glu
    210                 215                 220                 
Gln Cys Asp Val Leu Tyr Cys Ser Ala Cys Gln Leu Lys Cys His Pro
225                 230                 235                 240 
Ser Arg Gly Pro Phe Ala Lys His Arg Leu Ser Pro Gly Gly Ala Gly
                245                 250                 255     
Ala Gly Ala Thr Gly Gly Ser Thr Ala Arg Lys Phe Pro Thr Cys Pro
            260                 265                 270         
Glu His Glu Met Glu Asn Tyr Ser Met Tyr Cys Val Ser Cys Arg Thr
        275                 280                 285             
Pro Val Cys Tyr Leu Cys Leu Glu Glu Gly Arg His Ala Lys His Glu
    290                 295                 300                 
Val Lys Pro Leu Gly Ala Met Trp Lys Gln His Lys Ala Gln Leu Ser
305                 310                 315                 320 
Gln Ala Leu Asn Gly Val Ser Asp Lys Ala Lys Glu Ala Lys Glu Phe
                325                 330                 335     
Leu Val Gln Leu Lys Asn Ile Leu Gln Gln Ile Gln Glu Asn Gly Leu
            340                 345                 350         
Asp Tyr Glu Ala Cys Leu Val Ala Gln Cys Asp Ala Leu Val Asp Ala
        355                 360                 365             
Leu Thr Arg Gln Lys Ala Lys Leu Leu Thr Lys Val Thr Lys Glu Arg
    370                 375                 380                 
Glu His Lys Leu Lys Met Val Trp Asp Gln Ile Asn His Cys Thr Leu
385                 390                 395                 400 
Lys Leu Arg Gln Ser Thr Gly Leu Met Glu Tyr Cys Leu Glu Val Ile
                405                 410                 415     
Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln Ile Ser Asp Ala Leu Ile
            420                 425                 430         
Lys Arg Val Gln Val Ser Gln Glu Gln Trp Val Lys Gly Ala Leu Glu
        435                 440                 445             
Pro Lys Val Ser Ala Glu Phe Asp Leu Thr Leu Asp Ser Glu Pro Leu
    450                 455                 460                 
Leu Gln Ala Ile His Gln Leu Asp Phe Ile Gln Met Lys Cys Arg Val
465                 470                 475                 480 
Pro Pro Val Pro Leu Leu Gln Leu Glu Lys Cys Cys Thr Arg Asn Asn
                485                 490                 495     
Ser Val Thr Leu Ala Trp Arg Met Pro Pro Phe Thr His Ser Pro Val
            500                 505                 510         
Asp Gly Tyr Ile Leu Glu Leu Asp Asp Gly Ala Gly Gly Gln Phe Arg
        515                 520                 525             
Glu Val Tyr Val Gly Lys Glu Thr Leu Cys Thr Ile Asp Gly Leu His
    530                 535                 540                 
Phe Asn Ser Thr Tyr Asn Ala Arg Val Lys Ala Phe Asn Ser Ser Gly
545                 550                 555                 560 
Val Gly Pro Tyr Ser Lys Thr Val Val Leu Gln Thr Ser Asp Val Ala
                565                 570                 575     
Trp Phe Thr Phe Asp Pro Asn Ser Gly His Arg Asp Ile Ile Leu Ser
            580                 585                 590         
Asn Asp Asn Gln Thr Ala Thr Cys Ser Ser Tyr Asp Asp Arg Val Val
        595                 600                 605             
Leu Gly Thr Ala Ala Phe Ser Lys Gly Val His Tyr Trp Glu Leu His
    610                 615                 620                 
Val Asp Arg Tyr Asp Asn His Pro Asp Pro Ala Phe Gly Val Ala Arg
625                 630                 635                 640 
Ala Ser Val Val Lys Asp Met Met Leu Gly Lys Asp Asp Lys Ala Trp
                645                 650                 655     
Ala Met Tyr Val Asp Asn Asn Arg Ser Trp Phe Met His Cys Asn Ser
            660                 665                 670         
His Thr Asn Arg Thr Glu Gly Gly Val Cys Lys Gly Ala Thr Val Gly
        675                 680                 685             
Val Leu Leu Asp Leu Asn Lys His Thr Leu Thr Phe Phe Ile Asn Gly
    690                 695                 700                 
Gln Gln Gln Gly Pro Thr Ala Phe Ser His Val Asp Gly Val Phe Met
705                 710                 715                 720 
Pro Ala Leu Ser Leu Asn Arg Asn Val
                725                 


<210> 7730
<211> 342
<212> PRT
<213> Homo sapiens

<400> 7730
Met Val Ser Ile Pro Glu Tyr Tyr Glu Gly Lys Asn Val Leu Leu Thr
 1               5                  10                  15      
Gly Ala Thr Gly Phe Leu Gly Lys Val Leu Leu Glu Lys Leu Leu Arg
            20                  25                  30          
Ser Cys Pro Lys Val Asn Ser Val Tyr Val Leu Val Arg Gln Lys Ala
        35                  40                  45              
Gly Gln Thr Pro Gln Glu Arg Val Glu Glu Val Leu Ser Gly Lys Leu
    50                  55                  60                  
Phe Asp Arg Leu Arg Asp Glu Asn Pro Asp Phe Arg Glu Lys Ile Ile
65                  70                  75                  80  
Ala Ile Asn Ser Glu Leu Thr Gln Pro Lys Leu Ala Leu Ser Glu Glu
                85                  90                  95      
Asp Lys Glu Val Ile Ile Asp Ser Thr Asn Ile Ile Phe His Cys Ala
            100                 105                 110         
Ala Thr Val Arg Phe Asn Glu Asn Leu Arg Asp Ala Val Gln Leu Asn
        115                 120                 125             
Val Ile Ala Thr Arg Gln Leu Ile Leu Leu Ala Gln Gln Met Lys Asn
    130                 135                 140                 
Leu Glu Val Phe Met His Val Ser Thr Ala Tyr Ala Tyr Cys Asn Arg
145                 150                 155                 160 
Lys His Ile Asp Glu Val Val Tyr Pro Pro Pro Val Asp Pro Lys Lys
                165                 170                 175     
Leu Ile Asp Ser Leu Glu Trp Met Asp Asp Gly Leu Val Asn Asp Ile
            180                 185                 190         
Thr Pro Lys Leu Ile Gly Asp Arg Pro Asn Thr Tyr Ile Tyr Thr Lys
        195                 200                 205             
Ala Leu Ala Glu Tyr Val Val Gln Gln Glu Gly Ala Lys Leu Asn Val
    210                 215                 220                 
Ala Ile Val Arg Pro Ser Ile Val Gly Ala Ser Trp Lys Glu Pro Phe
225                 230                 235                 240 
Pro Gly Trp Ile Asp Asn Phe Asn Gly Pro Ser Gly Leu Phe Ile Ala
                245                 250                 255     
Ala Gly Lys Gly Ile Leu Arg Thr Ile Arg Ala Ser Asn Asn Ala Leu
            260                 265                 270         
Ala Asp Leu Val Pro Val Asp Val Val Val Asn Met Ser Leu Ala Ala
        275                 280                 285             
Ala Trp Tyr Ser Gly Val Asn Arg Pro Arg Asn Ile Met Val Tyr Asn
    290                 295                 300                 
Cys Thr Thr Gly Ser Thr Asn Pro Phe His Trp Gly Glu Val Gly Met
305                 310                 315                 320 
Ile Leu Pro Val Phe Leu Asn Val Arg Ile Asn Leu Lys Glu Pro Lys
                325                 330                 335     
Lys Lys Lys Lys Lys Lys
            340         


<210> 7731
<211> 380
<212> PRT
<213> Homo sapiens

<400> 7731
Asp Pro Glu Thr Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu
 1               5                  10                  15      
Trp Tyr Asp Pro Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe
            20                  25                  30          
Tyr Pro Gly Asp Gly Ser Val Glu Met His Asp Val Lys Asn His Arg
        35                  40                  45              
Thr Phe Leu Lys Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu
    50                  55                  60                  
Phe Ile Gly Asn Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile
65                  70                  75                  80  
Asp Tyr Gly Asp Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu
                85                  90                  95      
Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu
            100                 105                 110         
Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys
        115                 120                 125             
Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His
    130                 135                 140                 
Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly
145                 150                 155                 160 
Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp
                165                 170                 175     
Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala
            180                 185                 190         
Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala
        195                 200                 205             
Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu
    210                 215                 220                 
Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe
225                 230                 235                 240 
Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly
                245                 250                 255     
Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile
            260                 265                 270         
Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe
        275                 280                 285             
Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr
    290                 295                 300                 
Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn
305                 310                 315                 320 
Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile
                325                 330                 335     
Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr
            340                 345                 350         
Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu
        355                 360                 365             
Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn
    370                 375                 380 


<210> 7732
<211> 340
<212> PRT
<213> Homo sapiens

<400> 7732
Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys Arg Thr Lys Tyr
 1               5                  10                  15      
Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn Lys Val Asn Val
            20                  25                  30          
Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp Gln Tyr Thr Ala
        35                  40                  45              
Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala Leu Ile Lys Pro
    50                  55                  60                  
Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala
65                  70                  75                  80  
Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu
                85                  90                  95      
Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe Phe Asn Glu
            100                 105                 110         
Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met Glu Ile Leu
        115                 120                 125             
Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn
    130                 135                 140                 
Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe
145                 150                 155                 160 
Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro Asp Ser Phe Ala
                165                 170                 175     
Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys
            180                 185                 190         
Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr Cys Cys Ile Val
        195                 200                 205             
Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys Ile Leu Met Ala
    210                 215                 220                 
Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met
225                 230                 235                 240 
Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val
                245                 250                 255     
Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val
            260                 265                 270         
Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe
        275                 280                 285             
Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr
    290                 295                 300                 
Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys
305                 310                 315                 320 
Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys
                325                 330                 335     
Ile Leu Asp Asn
            340 


<210> 7733
<211> 104
<212> PRT
<213> Homo sapiens

<400> 7733
Met Ser Ile Arg Leu Thr Gln Lys Ser Tyr Lys Ala Ser Thr Ser Ile
 1               5                  10                  15      
Pro Gly Thr Phe Ser Arg Cys Ser Tyr Ala Arg Gly Pro Gly Ala His
            20                  25                  30          
Ile Gly Ser Leu Ser Phe Ser Arg Val Gly Ser Ser Arg Phe Gln Gly
        35                  40                  45              
Thr Leu Gly Arg Gly His Gly Gly Ala Ser Ser Ile Thr Arg Ala Met
    50                  55                  60                  
Val Asn Gln Ser Leu Leu Asn Pro Leu Asn Leu Glu Val Asp Pro Asn
65                  70                  75                  80  
Ile Gln Ala Val Cys Thr Gln Glu Lys Lys Gln Ile Lys Thr Leu Ser
                85                  90                  95      
Lys Phe Ala Ser Phe Ile Asp Lys
            100                 


<210> 7734
<211> 2847
<212> PRT
<213> Homo sapiens

<400> 7734
Cys Trp Cys Leu Gly Val Ser Thr Met Pro Ile Thr Gln Asp Asn Ala
 1               5                  10                  15      
Val Leu His Leu Pro Leu Leu Tyr Gln Trp Leu Gln Asn Ser Leu Gln
            20                  25                  30          
Glu Gly Gly Asp Gly Pro Glu Gln Arg Leu Cys Gln Ala Ala Ile Gln
        35                  40                  45              
Lys Leu Gln Glu Tyr Ile Gln Leu Asn Phe Ala Val Asp Glu Ser Thr
    50                  55                  60                  
Val Pro Pro Asp His Ser Pro Pro Glu Met Glu Ile Cys Thr Val Tyr
65                  70                  75                  80  
Leu Thr Lys Glu Leu Gly Asp Thr Glu Thr Val Gly Leu Ser Phe Gly
                85                  90                  95      
Asn Ile Pro Val Phe Gly Asp Tyr Gly Glu Lys Arg Arg Gly Gly Lys
            100                 105                 110         
Lys Arg Lys Thr His Gln Gly Pro Val Leu Asp Val Gly Cys Ile Trp
        115                 120                 125             
Val Thr Glu Leu Arg Lys Asn Ser Pro Ala Gly Lys Ser Gly Lys Val
    130                 135                 140                 
Arg Leu Arg Asp Glu Ile Leu Ser Leu Asn Gly Gln Leu Met Val Gly
145                 150                 155                 160 
Val Asp Val Ser Gly Ala Ser Tyr Leu Ala Glu Gln Cys Trp Asn Gly
                165                 170                 175     
Gly Phe Ile Tyr Leu Ile Met Leu Arg Arg Phe Lys His Lys Ala His
            180                 185                 190         
Ser Thr Tyr Asn Gly Asn Ser Ser Asn Ser Ser Glu Pro Gly Glu Thr
        195                 200                 205             
Pro Thr Leu Glu Leu Gly Asp Arg Thr Ala Lys Lys Gly Lys Arg Thr
    210                 215                 220                 
Arg Lys Phe Gly Val Ile Ser Arg Pro Pro Ala Asn Lys Ala Pro Glu
225                 230                 235                 240 
Glu Ser Lys Gly Ser Ala Gly Cys Glu Val Ser Ser Asp Pro Ser Thr
                245                 250                 255     
Glu Leu Glu Asn Gly Pro Asp Pro Glu Leu Gly Asn Gly His Val Phe
            260                 265                 270         
Gln Leu Glu Asn Gly Pro Asp Ser Leu Lys Glu Val Ala Gly Pro His
        275                 280                 285             
Leu Glu Arg Ser Glu Val Asp Arg Gly Thr Glu His Arg Ile Pro Lys
    290                 295                 300                 
Thr Asp Ala Pro Leu Thr Thr Ser Asn Asp Lys Arg Arg Phe Ser Lys
305                 310                 315                 320 
Gly Gly Lys Thr Asp Phe Gln Ser Ser Asp Cys Leu Ala Arg Glu Glu
                325                 330                 335     
Val Gly Arg Ile Trp Lys Met Glu Leu Leu Lys Glu Ser Asp Gly Leu
            340                 345                 350         
Gly Ile Gln Val Ser Gly Gly Arg Gly Ser Lys Arg Ser Pro His Ala
        355                 360                 365             
Ile Val Val Thr Gln Val Lys Glu Gly Gly Ala Ala His Arg Asp Gly
    370                 375                 380                 
Arg Leu Ser Leu Gly Asp Glu Leu Leu Val Ile Asn Gly His Leu Leu
385                 390                 395                 400 
Val Gly Leu Ser His Glu Glu Ala Val Ala Ile Leu Arg Ser Ala Thr
                405                 410                 415     
Gly Met Val Gln Leu Val Val Ala Ser Lys Glu Asn Ser Ala Glu Asp
            420                 425                 430         
Leu Leu Arg Leu Thr Ser Lys Ser Leu Pro Asp Leu Thr Ser Ser Val
        435                 440                 445             
Glu Asp Val Ser Ser Trp Thr Asp Asn Glu Asp Gln Glu Ala Asp Gly
    450                 455                 460                 
Glu Glu Asp Glu Gly Thr Ser Ser Ser Val Gln Arg Ala Met Pro Gly
465                 470                 475                 480 
Thr Asp Glu Pro Gln Asp Val Cys Gly Ala Glu Glu Ser Lys Gly Asn
                485                 490                 495     
Leu Glu Ser Pro Lys Gln Gly Ser Asn Lys Ile Lys Leu Lys Ser Arg
            500                 505                 510         
Leu Ser Gly Gly Val His Arg Leu Glu Ser Val Glu Glu Tyr Asn Glu
        515                 520                 525             
Leu Met Val Arg Asn Gly Asp Pro Arg Ile Arg Met Leu Glu Val Ser
    530                 535                 540                 
Arg Asp Gly Arg Lys His Ser Leu Pro Gln Leu Leu Asp Ser Ser Ser
545                 550                 555                 560 
Ala Ser Gln Glu Tyr His Ile Val Lys Lys Ser Thr Arg Ser Leu Ser
                565                 570                 575     
Thr Thr Gln Val Glu Ser Pro Trp Arg Leu Ile Arg Pro Ser Val Ile
            580                 585                 590         
Ser Ile Ile Gly Leu Tyr Lys Glu Lys Gly Lys Gly Leu Gly Phe Ser
        595                 600                 605             
Ile Ala Gly Gly Arg Asp Cys Ile Arg Gly Gln Met Gly Ile Phe Val
    610                 615                 620                 
Lys Thr Ile Phe Pro Asn Gly Ser Ala Ala Glu Asp Gly Arg Leu Lys
625                 630                 635                 640 
Glu Gly Asp Glu Ile Leu Asp Val Asn Gly Ile Pro Ile Lys Gly Leu
                645                 650                 655     
Thr Phe Gln Glu Ala Ile His Thr Phe Lys Gln Ile Arg Ser Gly Leu
            660                 665                 670         
Phe Val Leu Thr Val Arg Thr Lys Leu Val Ser Pro Ser Leu Thr Pro
        675                 680                 685             
Cys Ser Thr Pro Thr His Met Ser Arg Ser Ala Ser Pro Asn Phe Asn
    690                 695                 700                 
Thr Ser Gly Gly Ala Ser Ala Gly Gly Ser Asp Glu Gly Ser Ser Ser
705                 710                 715                 720 
Ser Leu Gly Arg Lys Thr Pro Gly Pro Lys Asp Arg Ile Val Met Glu
                725                 730                 735     
Val Thr Leu Asn Lys Glu Pro Arg Val Gly Leu Gly Ile Gly Ala Cys
            740                 745                 750         
Cys Leu Ala Leu Glu Asn Ser Pro Pro Gly Ile Tyr Ile His Ser Leu
        755                 760                 765             
Ala Pro Gly Ser Val Ala Lys Met Glu Ser Asn Leu Ser Arg Gly Asp
    770                 775                 780                 
Gln Ile Leu Glu Val Asn Ser Val Asn Val Arg His Ala Ala Leu Ser
785                 790                 795                 800 
Lys Val His Ala Ile Leu Ser Lys Cys Pro Pro Gly Pro Val Arg Leu
                805                 810                 815     
Val Ile Gly Arg His Pro Asn Pro Lys Val Ser Glu Gln Glu Met Asp
            820                 825                 830         
Glu Val Ile Ala Arg Ser Thr Tyr Gln Glu Ser Lys Glu Ala Asn Ser
        835                 840                 845             
Ser Pro Gly Leu Gly Thr Pro Leu Lys Ser Pro Ser Leu Ala Lys Lys
    850                 855                 860                 
Asp Ser Leu Ile Ser Glu Ser Glu Leu Ser Gln Tyr Phe Ala His Asp
865                 870                 875                 880 
Val Pro Gly Pro Leu Ser Asp Phe Met Val Ala Gly Ser Glu Asp Glu
                885                 890                 895     
Asp His Pro Gly Ser Gly Cys Ser Thr Ser Glu Glu Gly Ser Leu Pro
            900                 905                 910         
Pro Ser Thr Ser Thr His Lys Glu Pro Gly Lys Pro Arg Ala Asn Ser
        915                 920                 925             
Leu Val Thr Leu Gly Ser His Arg Ala Ser Gly Leu Phe His Lys Gln
    930                 935                 940                 
Val Thr Val Ala Arg Gln Ala Ser Leu Pro Gly Ser Pro Gln Ala Leu
945                 950                 955                 960 
Arg Asn Pro Leu Leu Arg Gln Arg Lys Val Gly Cys Tyr Asp Ala Asn
                965                 970                 975     
Asp Ala Ser Asp Glu Glu Glu Phe Asp Arg Glu Gly Asp Cys Ile Ser
            980                 985                 990         
Leu Pro Gly Ala Leu Pro Gly Pro Ile Arg Pro Leu Ser Glu Asp Asp
        995                 1000                1005            
Pro Arg Arg Val Ser Ile Ser Ser Ser Lys Gly Met Asp Val His Asn
    1010                1015                1020                
Gln Glu Glu Arg Pro Arg Lys Thr Leu Val Ser Lys Ala Ile Ser Ala
1025                1030                1035                1040
Pro Leu Leu Gly Ser Ser Val Asp Leu Glu Glu Ser Ile Pro Glu Gly
                1045                1050                1055    
Met Val Asp Ala Ala Ser Tyr Ala Ala Asn Leu Thr Asp Ser Ala Glu
            1060                1065                1070        
Ala Pro Lys Gly Ser Pro Gly Ser Trp Trp Lys Lys Glu Leu Ser Gly
        1075                1080                1085            
Ser Ser Ser Ala Pro Lys Leu Glu Tyr Thr Val Arg Thr Asp Thr Gln
    1090                1095                1100                
Ser Pro Thr Asn Thr Gly Ser Pro Ser Ser Pro Gln Gln Lys Ser Glu
1105                1110                1115                1120
Gly Leu Gly Ser Arg His Arg Pro Val Ala Arg Val Ser Pro His Cys
                1125                1130                1135    
Lys Arg Ser Glu Ala Glu Ala Lys Pro Ser Gly Ser Gln Thr Val Asn
            1140                1145                1150        
Leu Thr Gly Arg Ala Asn Asp Pro Cys Asp Leu Asp Ser Arg Val Gln
        1155                1160                1165            
Ala Thr Ser Val Lys Val Thr Val Ala Gly Phe Gln Pro Gly Gly Ala
    1170                1175                1180                
Val Glu Lys Glu Ser Leu Gly Lys Leu Thr Thr Gly Asp Ala Cys Val
1185                1190                1195                1200
Ser Thr Ser Cys Glu Leu Ala Ser Ala Leu Ser His Leu Asp Ala Ser
                1205                1210                1215    
His Leu Thr Glu Asn Leu Pro Lys Ala Ala Ser Glu Leu Gly Gln Gln
            1220                1225                1230        
Pro Met Thr Glu Leu Asp Ser Ser Ser Asp Leu Ile Ser Ser Pro Gly
        1235                1240                1245            
Lys Lys Gly Ala Ala His Pro Asp Pro Ser Lys Thr Ser Val Asp Thr
    1250                1255                1260                
Gly Gln Val Ser Arg Pro Glu Asn Pro Ser Gln Pro Ala Ser Pro Arg
1265                1270                1275                1280
Val Ala Lys Cys Lys Ala Arg Ser Pro Val Arg Leu Pro His Glu Gly
                1285                1290                1295    
Ser Pro Ser Pro Gly Glu Lys Ala Ala Ala Pro Pro Asp Tyr Ser Lys
            1300                1305                1310        
Thr Arg Ser Ala Ser Glu Thr Ser Thr Pro His Asn Thr Arg Arg Val
        1315                1320                1325            
Ala Ala Leu Arg Gly Ala Gly Pro Gly Ala Glu Gly Met Thr Pro Ala
    1330                1335                1340                
Gly Ala Val Leu Pro Gly Asp Pro Leu Thr Ser Gln Glu Gln Arg Gln
1345                1350                1355                1360
Gly Ala Pro Gly Asn His Ser Lys Ala Leu Glu Met Thr Gly Ile His
                1365                1370                1375    
Ala Pro Glu Ser Ser Gln Glu Pro Ser Leu Leu Glu Gly Ala Asp Ser
            1380                1385                1390        
Val Ser Ser Arg Ala Pro Gln Ala Ser Leu Ser Met Leu Pro Ser Thr
        1395                1400                1405            
Asp Asn Thr Lys Glu Ala Cys Gly His Val Ser Gly His Cys Cys Pro
    1410                1415                1420                
Gly Gly Ser Arg Glu Ser Pro Val Thr Asp Ile Asp Ser Phe Ile Lys
1425                1430                1435                1440
Glu Leu Asp Ala Ser Ala Ala Arg Ser Pro Ser Ser Gln Thr Gly Asp
                1445                1450                1455    
Ser Gly Ser Gln Glu Gly Ser Ala Gln Gly His Pro Pro Ala Gly Ala
            1460                1465                1470        
Gly Gly Gly Ser Ser Cys Arg Ala Glu Pro Val Pro Gly Gly Gln Thr
        1475                1480                1485            
Ser Ser Pro Arg Arg Ala Trp Ala Ala Gly Ala Pro Ala Tyr Pro Gln
    1490                1495                1500                
Trp Ala Ser Gln Pro Ser Val Leu Asp Ser Ile Asn Pro Asp Lys His
1505                1510                1515                1520
Phe Thr Val Asn Lys Asn Phe Leu Ser Asn Tyr Ser Arg Asn Phe Ser
                1525                1530                1535    
Ser Phe His Glu Asp Ser Thr Ser Leu Ser Gly Leu Gly Asp Ser Thr
            1540                1545                1550        
Glu Pro Ser Leu Ser Ser Met Tyr Gly Asp Ala Glu Asp Ser Ser Ser
        1555                1560                1565            
Asp Pro Glu Ser Leu Thr Glu Ala Pro Arg Ala Ser Ala Arg Asp Gly
    1570                1575                1580                
Trp Ser Pro Pro Arg Ser Arg Val Ser Leu His Lys Glu Asp Pro Ser
1585                1590                1595                1600
Glu Ser Glu Glu Glu Gln Ile Glu Ile Cys Ser Thr Arg Gly Cys Pro
                1605                1610                1615    
Asn Pro Pro Ser Ser Pro Ala His Leu Pro Thr Gln Ala Ala Ile Cys
            1620                1625                1630        
Pro Ala Ser Ala Lys Val Leu Ser Leu Lys Tyr Ser Thr Pro Arg Glu
        1635                1640                1645            
Ser Val Ala Ser Pro Arg Glu Lys Ala Ala Cys Leu Pro Gly Ser Tyr
    1650                1655                1660                
Thr Ser Gly Pro Asp Ser Ser Gln Pro Ser Ser Leu Leu Glu Met Ser
1665                1670                1675                1680
Ser Gln Glu His Glu Thr His Ala Asp Ile Ser Thr Ser Gln Asn His
                1685                1690                1695    
Arg Pro Ser Cys Ala Glu Glu Thr Thr Glu Val Thr Ser Ala Ser Ser
            1700                1705                1710        
Ala Met Glu Asn Ser Pro Leu Ser Lys Val Ala Arg His Phe His Ser
        1715                1720                1725            
Pro Pro Ile Ile Leu Ser Ser Pro Asn Met Val Asn Gly Leu Glu His
    1730                1735                1740                
Asp Leu Leu Asp Asp Glu Thr Leu Asn Gln Tyr Glu Thr Ser Ile Asn
1745                1750                1755                1760
Ala Ala Ala Ser Leu Ser Ser Phe Ser Val Asp Val Pro Lys Asn Gly
                1765                1770                1775    
Glu Ser Val Leu Glu Asn Leu His Ile Ser Glu Ser Gln Asp Leu Asp
            1780                1785                1790        
Asp Leu Leu Gln Lys Pro Lys Met Ile Ala Arg Arg Pro Ile Met Ala
        1795                1800                1805            
Trp Phe Lys Glu Ile Asn Lys His Asn Gln Gly Thr His Leu Arg Ser
    1810                1815                1820                
Lys Thr Glu Lys Glu Gln Pro Leu Met Pro Ala Arg Ser Pro Asp Ser
1825                1830                1835                1840
Lys Ile Gln Met Val Ser Ser Ser Gln Lys Lys Gly Val Thr Val Pro
                1845                1850                1855    
His Ser Pro Pro Gln Pro Lys Thr Asn Leu Glu Asn Lys Asp Leu Ser
            1860                1865                1870        
Lys Lys Ser Pro Ala Glu Met Leu Leu Thr Asn Gly Gln Lys Ala Lys
        1875                1880                1885            
Cys Gly Pro Lys Leu Lys Arg Leu Ser Leu Lys Gly Lys Ala Lys Val
    1890                1895                1900                
Asn Ser Glu Ala Pro Ala Ala Asn Ala Val Lys Ala Gly Gly Thr Asp
1905                1910                1915                1920
His Arg Lys Pro Leu Ile Ser Pro Gln Thr Ser His Lys Thr Leu Ser
                1925                1930                1935    
Lys Ala Val Ser Gln Arg Leu His Val Ala Asp His Glu Asp Pro Asp
            1940                1945                1950        
Arg Asn Thr Thr Ala Ala Pro Arg Ser Pro Gln Cys Val Leu Glu Ser
        1955                1960                1965            
Lys Pro Pro Leu Ala Thr Ser Gly Pro Leu Lys Pro Ser Val Ser Asp
    1970                1975                1980                
Thr Ser Ile Arg Thr Phe Val Ser Pro Leu Thr Ser Pro Lys Pro Val
1985                1990                1995                2000
Pro Glu Gln Gly Met Trp Ser Arg Phe His Met Ala Val Leu Ser Glu
                2005                2010                2015    
Pro Asp Arg Gly Cys Pro Thr Thr Pro Lys Ser Pro Lys Cys Arg Ala
            2020                2025                2030        
Glu Gly Arg Ala Pro Arg Ala Asp Ser Gly Pro Val Ser Pro Ala Ala
        2035                2040                2045            
Ser Arg Asn Gly Met Ser Val Ala Gly Asn Arg Gln Ser Glu Pro Arg
    2050                2055                2060                
Leu Ala Ser His Val Ala Ala Asp Thr Ala Gln Pro Arg Pro Thr Gly
2065                2070                2075                2080
Glu Lys Gly Gly Asn Ile Met Ala Ser Asp Arg Leu Glu Arg Thr Asn
                2085                2090                2095    
Gln Leu Lys Ile Val Glu Ile Ser Ala Glu Ala Val Ser Glu Thr Val
            2100                2105                2110        
Cys Gly Asn Lys Pro Ala Glu Ser Asp Arg Arg Gly Gly Cys Leu Ala
        2115                2120                2125            
Gln Gly Asn Cys Gln Glu Lys Ser Glu Ile Arg Leu Tyr Arg Gln Val
    2130                2135                2140                
Ala Glu Ser Ser Thr Ser His Pro Ser Ser Leu Pro Ser His Ala Ser
2145                2150                2155                2160
Gln Ala Glu Gln Glu Met Ser Arg Ser Phe Ser Met Ala Lys Leu Ala
                2165                2170                2175    
Ser Ser Ser Ser Ser Leu Gln Thr Ala Ile Arg Lys Ala Glu Tyr Ser
            2180                2185                2190        
Gln Gly Lys Ser Ser Leu Met Ser Asp Ser Arg Gly Val Pro Arg Asn
        2195                2200                2205            
Ser Ile Pro Gly Gly Pro Ser Gly Glu Asp His Leu Tyr Phe Thr Pro
    2210                2215                2220                
Arg Pro Ala Thr Arg Thr Tyr Ser Met Pro Ala Gln Phe Ser Ser His
2225                2230                2235                2240
Phe Gly Arg Glu Gly His Pro Pro His Ser Leu Gly Arg Ser Arg Asp
                2245                2250                2255    
Ser Gln Val Pro Val Thr Ser Ser Val Val Pro Glu Ala Lys Ala Ser
            2260                2265                2270        
Arg Gly Gly Leu Pro Ser Leu Ala Asn Gly Gln Gly Ile Tyr Ser Val
        2275                2280                2285            
Lys Pro Leu Leu Asp Thr Ser Arg Asn Leu Pro Ala Thr Asp Glu Gly
    2290                2295                2300                
Asp Ile Ile Ser Val Gln Glu Thr Ser Cys Leu Val Thr Asp Lys Ile
2305                2310                2315                2320
Lys Val Thr Arg Arg His Tyr Cys Tyr Glu Gln Asn Trp Pro His Glu
                2325                2330                2335    
Ser Thr Ser Phe Phe Ser Val Lys Gln Arg Ile Lys Ser Phe Glu Asn
            2340                2345                2350        
Leu Ala Asn Ala Asp Arg Pro Val Ala Lys Ser Gly Ala Ser Pro Phe
        2355                2360                2365            
Leu Ser Val Ser Ser Lys Pro Pro Ile Gly Arg Arg Ser Ser Gly Ser
    2370                2375                2380                
Ile Val Ser Gly Ser Leu Gly His Pro Gly Asp Ala Ala Ala Arg Leu
2385                2390                2395                2400
Leu Arg Arg Ser Leu Ser Ser Cys Ser Glu Asn Gln Ser Glu Ala Gly
                2405                2410                2415    
Thr Leu Leu Pro Gln Met Ala Lys Ser Pro Ser Ile Met Thr Leu Thr
            2420                2425                2430        
Ile Ser Arg Gln Asn Pro Pro Glu Thr Ser Ser Lys Gly Ser Asp Ser
        2435                2440                2445            
Glu Leu Lys Lys Ser Leu Gly Pro Leu Gly Ile Pro Thr Pro Thr Met
    2450                2455                2460                
Thr Leu Ala Ser Pro Val Lys Arg Asn Lys Ser Ser Val Arg His Thr
2465                2470                2475                2480
Gln Pro Ser Pro Val Ser Arg Ser Lys Leu Gln Glu Leu Arg Ala Leu
                2485                2490                2495    
Ser Met Pro Asp Leu Asp Lys Leu Cys Ser Glu Asp Tyr Ser Ala Gly
            2500                2505                2510        
Pro Ser Ala Val Leu Phe Lys Thr Glu Leu Glu Ile Thr Pro Arg Arg
        2515                2520                2525            
Ser Pro Gly Pro Pro Ala Gly Gly Val Ser Cys Pro Glu Lys Gly Gly
    2530                2535                2540                
Asn Arg Ala Cys Pro Gly Gly Ser Gly Pro Lys Thr Ser Ala Ala Glu
2545                2550                2555                2560
Thr Pro Ser Ser Ala Ser Asp Thr Gly Glu Ala Ala Gln Asp Leu Pro
                2565                2570                2575    
Phe Arg Arg Ser Trp Ser Val Asn Leu Asp Gln Leu Leu Val Ser Ala
            2580                2585                2590        
Gly Asp Gln Gln Arg Leu Gln Ser Val Leu Ser Ser Val Gly Ser Lys
        2595                2600                2605            
Ser Thr Ile Leu Thr Leu Ile Gln Glu Ala Lys Ala Gln Ser Glu Asn
    2610                2615                2620                
Glu Glu Asp Val Cys Phe Ile Val Leu Asn Arg Lys Glu Gly Ser Gly
2625                2630                2635                2640
Leu Gly Phe Ser Val Ala Gly Gly Thr Asp Val Glu Pro Lys Ser Ile
                2645                2650                2655    
Thr Val His Arg Val Phe Ser Gln Gly Ala Ala Ser Gln Glu Gly Thr
            2660                2665                2670        
Met Asn Arg Gly Asp Phe Leu Leu Ser Val Asn Gly Ala Ser Leu Ala
        2675                2680                2685            
Gly Leu Ala His Gly Asn Val Leu Lys Val Leu His Gln Ala Gln Leu
    2690                2695                2700                
His Lys Asp Ala Leu Val Val Ile Lys Lys Gly Met Asp Gln Pro Arg
2705                2710                2715                2720
Pro Ser Ala Arg Gln Glu Pro Pro Thr Ala Asn Gly Lys Gly Leu Leu
                2725                2730                2735    
Ser Arg Lys Thr Ile Pro Leu Glu Pro Gly Ile Gly Arg Ser Val Ala
            2740                2745                2750        
Val His Asp Ala Leu Cys Val Glu Val Leu Lys Thr Ser Ala Gly Leu
        2755                2760                2765            
Gly Leu Ser Leu Asp Gly Gly Lys Ser Ser Val Thr Gly Asp Gly Pro
    2770                2775                2780                
Leu Val Ile Lys Arg Val Tyr Lys Gly Gly Ala Ala Glu Gln Ala Gly
2785                2790                2795                2800
Ile Ile Glu Ala Gly Asp Glu Ile Leu Ala Ile Asn Gly Lys Pro Leu
                2805                2810                2815    
Val Gly Leu Met His Phe Asp Ala Trp Asn Ile Met Lys Ser Val Pro
            2820                2825                2830        
Glu Gly Pro Val Gln Leu Leu Ile Arg Lys His Arg Asn Ser Ser
        2835                2840                2845        


<210> 7735
<211> 2641
<212> PRT
<213> Homo sapiens

<400> 7735
Met Pro Ile Thr Gln Asp Asn Ala Val Leu His Leu Pro Leu Leu Tyr
 1               5                  10                  15      
Gln Trp Leu Gln Asn Ser Leu Gln Glu Gly Gly Asp Gly Pro Glu Gln
            20                  25                  30          
Arg Leu Cys Gln Ala Ala Ile Gln Lys Leu Gln Glu Tyr Ile Gln Leu
        35                  40                  45              
Asn Phe Ala Val Asp Glu Ser Thr Val Pro Pro Asp His Ser Pro Pro
    50                  55                  60                  
Glu Met Glu Ile Cys Thr Val Tyr Leu Thr Lys Glu Leu Gly Asp Thr
65                  70                  75                  80  
Glu Thr Val Gly Leu Ser Phe Gly Asn Ile Pro Val Phe Gly Asp Tyr
                85                  90                  95      
Gly Glu Lys Arg Arg Gly Gly Lys Lys Arg Lys Thr His Gln Gly Pro
            100                 105                 110         
Val Leu Asp Val Gly Cys Ile Trp Val Thr Glu Leu Arg Lys Asn Ser
        115                 120                 125             
Pro Ala Gly Lys Ser Gly Lys Val Arg Leu Arg Asp Glu Ile Leu Ser
    130                 135                 140                 
Leu Asn Gly Gln Leu Met Val Gly Val Asp Val Ser Gly Ala Ser Tyr
145                 150                 155                 160 
Leu Ala Glu Gln Cys Trp Asn Gly Gly Phe Ile Tyr Leu Ile Met Leu
                165                 170                 175     
Arg Arg Phe Lys His Lys Ala His Ser Thr Tyr Asn Gly Asn Ser Ser
            180                 185                 190         
Asn Ser Ser Glu Pro Gly Glu Thr Pro Thr Leu Glu Leu Gly Asp Arg
        195                 200                 205             
Thr Ala Lys Lys Gly Lys Arg Thr Arg Lys Phe Gly Val Ile Ser Arg
    210                 215                 220                 
Pro Pro Ala Asn Lys Ala Pro Glu Glu Ser Lys Gly Ser Ala Gly Cys
225                 230                 235                 240 
Glu Val Ser Ser Asp Pro Ser Thr Glu Leu Glu Asn Gly Ala Asp Pro
                245                 250                 255     
Glu Leu Gly Asn Gly His Val Phe Gln Leu Glu Asn Gly Pro Asp Ser
            260                 265                 270         
Leu Lys Glu Val Ala Gly Pro His Leu Glu Arg Ser Glu Val Asp Arg
        275                 280                 285             
Gly Thr Glu His Arg Ile Pro Lys Thr Asp Ala Pro Leu Thr Thr Ser
    290                 295                 300                 
Asn Asp Lys Arg Arg Phe Ser Lys Gly Gly Lys Thr Asp Phe Gln Ser
305                 310                 315                 320 
Ser Asp Cys Leu Ala Arg Gln Glu Glu Val Gly Arg Ile Trp Lys Met
                325                 330                 335     
Glu Leu Leu Lys Glu Ser Asp Gly Leu Gly Ile Gln Val Ser Gly Gly
            340                 345                 350         
Arg Gly Ser Lys Arg Ser Pro His Ala Ile Val Val Thr Gln Val Lys
        355                 360                 365             
Glu Gly Gly Ala Ala His Arg Glu Tyr His Ile Val Lys Lys Ser Thr
    370                 375                 380                 
Arg Ser Leu Ser Thr Thr Gln Val Glu Ser Pro Trp Arg Leu Ile Arg
385                 390                 395                 400 
Pro Ser Val Ile Ser Ile Ile Gly Leu Tyr Lys Glu Lys Gly Lys Gly
                405                 410                 415     
Leu Gly Phe Ser Ile Ala Gly Gly Arg Asp Cys Ile Arg Gly Gln Met
            420                 425                 430         
Gly Ile Phe Val Lys Thr Ile Phe Pro Asn Gly Ser Ala Ala Glu Asp
        435                 440                 445             
Gly Arg Leu Lys Glu Gly Asp Glu Ile Leu Asp Val Asn Gly Ile Pro
    450                 455                 460                 
Ile Lys Gly Leu Thr Phe Gln Glu Ala Ile His Thr Phe Lys Gln Ile
465                 470                 475                 480 
Arg Ser Gly Leu Phe Val Leu Thr Val Arg Thr Lys Leu Val Ser Pro
                485                 490                 495     
Ser Leu Thr Pro Cys Ser Thr Pro Thr His Met Ser Arg Ser Ala Ser
            500                 505                 510         
Pro Asn Phe Asn Thr Ser Gly Gly Ala Ser Ala Gly Gly Ser Asp Glu
        515                 520                 525             
Gly Ser Ser Ser Ser Leu Gly Arg Lys Thr Pro Gly Pro Lys Asp Arg
    530                 535                 540                 
Ile Val Met Glu Val Thr Leu Asn Lys Glu Pro Arg Val Gly Leu Gly
545                 550                 555                 560 
Ile Gly Ala Cys Cys Leu Ala Leu Glu Asn Ser Pro Pro Gly Ile Tyr
                565                 570                 575     
Ile His Ser Leu Ala Pro Gly Ser Val Ala Lys Met Glu Ser Asn Leu
            580                 585                 590         
Ser Arg Gly Asp Gln Ile Leu Glu Val Asn Ser Val Asn Val Arg His
        595                 600                 605             
Ala Ala Leu Ser Lys Val His Ala Ile Leu Ser Lys Cys Pro Val Ser
    610                 615                 620                 
Glu Gln Glu Met Asp Glu Val Ile Ala Arg Ser Thr Tyr Gln Glu Ser
625                 630                 635                 640 
Lys Glu Ala Asn Ser Ser Pro Gly Leu Gly Thr Pro Leu Lys Ser Pro
                645                 650                 655     
Ser Leu Ala Lys Lys Asp Ser Leu Ile Ser Glu Ser Glu Leu Ser Gln
            660                 665                 670         
Tyr Phe Ala His Asp Val Pro Gly Pro Leu Ser Asp Phe Met Val Ala
        675                 680                 685             
Gly Ser Glu Asp Glu Asp His Pro Gly Ser Gly Cys Ser Thr Ser Glu
    690                 695                 700                 
Glu Gly Ser Leu Pro Pro Ser Thr Ser Ser Glu Pro Gly Lys Pro Arg
705                 710                 715                 720 
Ala Asn Ser Leu Val Thr Leu Gly Ser His Arg Ala Ser Gly Leu Phe
                725                 730                 735     
His Lys Gln Val Thr Val Ala Arg Gln Ala Ser Leu Pro Gly Ser Pro
            740                 745                 750         
Gln Ala Leu Arg Asn Pro Leu Leu Arg Gln Arg Lys Val Gly Cys Tyr
        755                 760                 765             
Asp Ala Asn Asp Ala Ser Asp Glu Glu Glu Phe Asp Arg Glu Gly Asp
    770                 775                 780                 
Cys Ile Ser Leu Pro Gly Ala Leu Pro Gly Pro Ile Arg Pro Leu Ser
785                 790                 795                 800 
Glu Asp Asp Pro Arg Arg Val Ser Ile Ser Ser Ser Lys Gly Met Asp
                805                 810                 815     
Val His Asn Gln Glu Glu Arg Pro Arg Lys Thr Leu Val Ser Lys Ala
            820                 825                 830         
Ile Ser Ala Pro Leu Leu Gly Ser Ser Val Asp Leu Glu Glu Ser Ile
        835                 840                 845             
Pro Glu Gly Met Val Asp Ala Ala Ser Tyr Ala Ala Asn Leu Thr Asp
    850                 855                 860                 
Ser Ala Glu Ala Pro Lys Gly Ser Pro Gly Ser Trp Trp Lys Lys Glu
865                 870                 875                 880 
Leu Ser Gly Ser Ser Ser Ala Pro Lys Leu Glu Tyr Thr Val Arg Thr
                885                 890                 895     
Asp Thr Gln Ser Pro Thr Asn Thr Gly Ser Pro Ser Ser Pro Gln Gln
            900                 905                 910         
Lys Ser Glu Gly Leu Gly Ser Arg His Arg Pro Val Ala Arg Val Ser
        915                 920                 925             
Pro His Cys Lys Arg Ser Glu Ala Glu Ala Lys Pro Ser Gly Ser Gln
    930                 935                 940                 
Thr Val Asn Leu Thr Gly Arg Ala Asn Asp Pro Cys Asp Leu Asp Ser
945                 950                 955                 960 
Arg Val Gln Ala Thr Ser Val Lys Val Thr Val Ala Gly Phe Gln Pro
                965                 970                 975     
Gly Gly Ala Val Glu Lys Leu Cys Gln Glu Ser Leu Gly Lys Leu Thr
            980                 985                 990         
Thr Gly Asp Ala Cys Val Ser Thr Ser Cys Glu Leu Ala Ser Ala Leu
        995                 1000                1005            
Ser His Leu Asp Ala Ser His Leu Thr Glu Asn Leu Pro Lys Ala Ala
    1010                1015                1020                
Ser Glu Leu Gly Gln Gln Pro Met Thr Ser Ser Asp Leu Ile Ser Ser
1025                1030                1035                1040
Pro Gly Lys Lys Gly Ala Ala His Pro Asp Pro Ser Lys Thr Ser Val
                1045                1050                1055    
Asp Thr Gly Gln Val Ser Arg Pro Glu Asn Pro Ser Gln Pro Ala Ser
            1060                1065                1070        
Pro Arg Val Thr Lys Cys Lys Ala Arg Ser Pro Val Arg Leu Pro His
        1075                1080                1085            
Glu Gly Ser Pro Ser Pro Gly Glu Lys Ala Ala Ala Pro Pro Asp Tyr
    1090                1095                1100                
Ser Lys Thr Arg Ser Ala Ser Glu Thr Ser Thr Pro His Asn Thr Arg
1105                1110                1115                1120
Arg Val Ala Ala Leu Arg Gly Ala Gly Pro Gly Ala Glu Gly Met Thr
                1125                1130                1135    
Pro Ala Gly Ala Val Leu Pro Gly Asp Pro Leu Thr Ser Gln Glu Gln
            1140                1145                1150        
Arg Gln Gly Ala Pro Gly Asn His Ser Lys Ala Leu Glu Met Thr Gly
        1155                1160                1165            
Ile His Ala Pro Glu Ser Ser Gln Glu Pro Ser Leu Leu Glu Gly Ala
    1170                1175                1180                
Asp Ser Val Ser Ser Arg Ala Pro Gln Ala Ser Leu Ser Met Leu Pro
1185                1190                1195                1200
Ser Thr Asp Asn Thr Lys Glu Ala Cys Gly His Val Ser Gly His Cys
                1205                1210                1215    
Cys Pro Gly Gly Ser Arg Glu Ser Pro Val Thr Asp Ile Asp Ser Phe
            1220                1225                1230        
Ile Lys Glu Leu Asp Ala Ser Ala Ala Arg Ser Pro Ser Ser Gln Thr
        1235                1240                1245            
Gly Asp Ser Gly Ser Gln Glu Gly Ser Ala Gln Gly His Pro Pro Ala
    1250                1255                1260                
Gly Ala Gly Gly Gly Ser Ser Cys Arg Ala Glu Pro Val Pro Gly Gly
1265                1270                1275                1280
Gln Thr Ser Ser Pro Arg Arg Ala Trp Ala Ala Gly Ala Pro Ala Tyr
                1285                1290                1295    
Pro Gln Trp Ala Ser Gln Pro Ser Val Leu Asp Ser Ile Asn Pro Asp
            1300                1305                1310        
Lys His Phe Thr Val Asn Lys Asn Phe Leu Ser Asn Tyr Ser Arg Asn
        1315                1320                1325            
Phe Ser Ser Phe His Glu Asp Ser Thr Ser Leu Ser Gly Leu Gly Asp
    1330                1335                1340                
Ser Thr Glu Pro Ser Leu Ser Ser Met Tyr Gly Asp Ala Glu Asp Ser
1345                1350                1355                1360
Ser Ser Asp Pro Glu Ser Leu Thr Glu Ala Pro Arg Ala Ser Ala Arg
                1365                1370                1375    
Asp Gly Trp Ser Pro Pro Arg Ser Arg Val Ser Leu His Lys Glu Asp
            1380                1385                1390        
Pro Ser Glu Ser Glu Glu Glu Gln Ile Glu Ile Cys Ser Thr Arg Gly
        1395                1400                1405            
Cys Pro Asn Pro Pro Ser Ser Pro Ala His Leu Pro Thr Gln Ala Ala
    1410                1415                1420                
Ile Cys Pro Ala Ser Ala Lys Val Leu Ser Leu Lys Tyr Ser Thr Pro
1425                1430                1435                1440
Arg Glu Ser Val Ala Ser Pro Arg Glu Lys Ala Ala Cys Leu Pro Gly
                1445                1450                1455    
Ser Tyr Thr Ser Gly Pro Asp Ser Ser Gln Pro Ser Ser Leu Leu Glu
            1460                1465                1470        
Met Ser Ser Gln Glu His Glu Thr His Ala Asp Ile Ser Thr Ser Gln
        1475                1480                1485            
Asn His Arg Pro Ser Cys Ala Glu Glu Thr Thr Glu Val Thr Ser Ala
    1490                1495                1500                
Ser Ser Ala Met Glu Asn Ser Pro Leu Ser Lys Val Ala Arg His Phe
1505                1510                1515                1520
His Ser Pro Pro Ile Ile Leu Ser Ser Pro Asn Met Val Asn Gly Leu
                1525                1530                1535    
Glu His Asp Leu Leu Asp Asp Glu Thr Leu Asn Gln Tyr Glu Thr Ser
            1540                1545                1550        
Ile Asn Ala Ala Ala Ser Leu Ser Ser Phe Ser Val Asp Val Pro Lys
        1555                1560                1565            
Asn Gly Glu Ser Val Leu Glu Asn Leu His Ile Ser Glu Ser Gln Asp
    1570                1575                1580                
Leu Asp Asp Leu Leu Gln Lys Pro Lys Met Ile Ala Arg Arg Pro Ile
1585                1590                1595                1600
Met Ala Trp Phe Lys Glu Ile Asn Lys His Asn Gln Gly Thr His Leu
                1605                1610                1615    
Arg Ser Lys Thr Glu Lys Glu Gln Pro Leu Met Pro Ala Arg Ser Pro
            1620                1625                1630        
Asp Ser Lys Ile Gln Met Val Ser Ser Ser Gln Lys Lys Gly Val Thr
        1635                1640                1645            
Val Pro His Ser Pro Pro Gln Pro Lys Thr Asn Leu Glu Asn Lys Asp
    1650                1655                1660                
Leu Ser Lys Lys Ser Pro Ala Glu Met Leu Leu Thr Asn Gly Gln Lys
1665                1670                1675                1680
Ala Lys Cys Gly Pro Lys Leu Lys Arg Leu Ser Leu Lys Gly Lys Ala
                1685                1690                1695    
Lys Val Asn Ser Glu Ala Pro Ala Ala Asn Ala Val Lys Ala Gly Gly
            1700                1705                1710        
Thr Asp His Arg Lys Pro Leu Ile Ser Pro Gln Thr Ser His Lys Thr
        1715                1720                1725            
Leu Ser Lys Ala Val Ser Gln Arg Leu His Val Ala Asp His Glu Asp
    1730                1735                1740                
Pro Asp Arg Asn Thr Thr Ala Ala Pro Arg Ser Pro Gln Cys Val Leu
1745                1750                1755                1760
Glu Ser Lys Pro Pro Leu Ala Thr Ser Gly Pro Leu Lys Pro Ser Val
                1765                1770                1775    
Ser Asp Thr Ser Ile Arg Thr Phe Val Ser Pro Leu Thr Ser Pro Lys
            1780                1785                1790        
Pro Val Pro Glu Gln Gly Met Trp Ser Arg Phe His Met Ala Val Leu
        1795                1800                1805            
Ser Glu Pro Asp Arg Gly Cys Pro Thr Thr Pro Lys Ser Pro Lys Cys
    1810                1815                1820                
Arg Ala Glu Gly Arg Ala Pro Arg Ala Asp Ser Gly Pro Val Ser Pro
1825                1830                1835                1840
Ala Ala Ser Arg Asn Gly Met Ser Val Ala Gly Asn Arg Gln Ser Glu
                1845                1850                1855    
Pro Arg Leu Ala Ser His Val Ala Ala Asp Thr Ala Gln Pro Arg Pro
            1860                1865                1870        
Thr Gly Glu Lys Gly Gly Asn Ile Met Ala Ser Asp Arg Leu Glu Arg
        1875                1880                1885            
Thr Asn Gln Leu Lys Ile Val Glu Ile Ser Ala Glu Ala Val Ser Glu
    1890                1895                1900                
Thr Val Cys Gly Asn Lys Pro Ala Glu Ser Asp Arg Arg Gly Gly Cys
1905                1910                1915                1920
Leu Ala Gln Gly Asn Cys Gln Glu Lys Ser Glu Ile Arg Leu Tyr Arg
                1925                1930                1935    
Gln Val Ala Glu Ser Ser Thr Ser His Pro Ser Ser Leu Pro Ser His
            1940                1945                1950        
Ala Ser Gln Ala Glu Gln Glu Met Ser Arg Ser Phe Ser Met Ala Lys
        1955                1960                1965            
Leu Ala Ser Ser Ser Ser Ser Leu Gln Thr Ala Ile Arg Lys Ala Glu
    1970                1975                1980                
Tyr Ser Gln Gly Lys Ser Ser Leu Met Ser Asp Ser Arg Gly Val Pro
1985                1990                1995                2000
Arg Asn Ser Ile Pro Gly Gly Pro Ser Gly Glu Asp His Leu Tyr Phe
                2005                2010                2015    
Thr Pro Arg Pro Ala Thr Arg Thr Tyr Ser Met Pro Ala Gln Phe Ser
            2020                2025                2030        
Ser His Phe Gly Arg Glu Gly His Pro Pro His Ser Leu Gly Arg Ser
        2035                2040                2045            
Arg Asp Ser Gln Val Pro Val Thr Ser Ser Val Val Pro Glu Ala Lys
    2050                2055                2060                
Ala Ser Arg Gly Gly Leu Pro Ser Leu Ala Asn Gly Gln Gly Ile Tyr
2065                2070                2075                2080
Ser Val Lys Pro Leu Leu Asp Thr Ser Arg Asn Leu Pro Ala Thr Asp
                2085                2090                2095    
Glu Gly Asp Ile Ile Ser Val Gln Glu Thr Ser Cys Leu Val Thr Asp
            2100                2105                2110        
Lys Ile Lys Val Thr Arg Arg His Tyr Cys Tyr Glu Gln Asn Trp Pro
        2115                2120                2125            
His Glu Ser Thr Ser Phe Phe Ser Val Lys Gln Arg Ile Lys Ser Phe
    2130                2135                2140                
Glu Asn Leu Ala Asn Ala Asp Arg Pro Val Ala Lys Ser Gly Ala Ser
2145                2150                2155                2160
Pro Phe Leu Ser Val Ser Ser Lys Pro Pro Ile Gly Arg Arg Ser Ser
                2165                2170                2175    
Gly Ser Ile Val Ser Gly Ser Leu Gly His Pro Gly Asp Ala Ala Ala
            2180                2185                2190        
Arg Leu Leu Arg Arg Ser Leu Ser Ser Cys Ser Glu Asn Gln Ser Glu
        2195                2200                2205            
Ala Gly Thr Leu Leu Pro Gln Met Ala Lys Ser Pro Ser Ile Met Thr
    2210                2215                2220                
Leu Thr Ile Ser Arg Gln Asn Pro Pro Glu Thr Ser Ser Lys Gly Ser
2225                2230                2235                2240
Asp Ser Glu Leu Lys Lys Ser Leu Gly Pro Leu Gly Ile Pro Thr Pro
                2245                2250                2255    
Thr Met Thr Leu Ala Ser Pro Val Lys Arg Asn Lys Ser Ser Val Arg
            2260                2265                2270        
His Thr Gln Pro Ser Pro Val Ser Arg Ser Lys Leu Gln Glu Leu Arg
        2275                2280                2285            
Ala Leu Ser Met Pro Asp Leu Asp Lys Leu Cys Ser Glu Asp Tyr Ser
    2290                2295                2300                
Ala Gly Pro Ser Ala Val Leu Phe Lys Thr Glu Leu Glu Ile Thr Pro
2305                2310                2315                2320
Arg Arg Ser Pro Gly Pro Pro Ala Gly Gly Val Ser Cys Pro Glu Lys
                2325                2330                2335    
Gly Gly Asn Arg Ala Cys Pro Gly Gly Ser Gly Pro Lys Thr Ser Ala
            2340                2345                2350        
Ala Glu Thr Pro Ser Ser Ala Ser Asp Thr Gly Glu Ala Ala Gln Asp
        2355                2360                2365            
Leu Pro Phe Arg Arg Ser Trp Ser Val Lys Leu Asp Gln Leu Leu Val
    2370                2375                2380                
Ser Ala Gly Asp Gln Gln Arg Leu Gln Ser Val Leu Ser Ser Val Gly
2385                2390                2395                2400
Ser Lys Ser Thr Ile Leu Thr Leu Ile Gln Glu Ala Lys Ala Gln Ser
                2405                2410                2415    
Glu Asn Glu Glu Asp Val Cys Phe Ile Val Leu Asn Arg Lys Glu Gly
            2420                2425                2430        
Ser Gly Leu Gly Phe Ser Val Ala Gly Gly Thr Asp Val Glu Pro Lys
        2435                2440                2445            
Ser Ile Thr Val His Arg Val Phe Ser Gln Gly Ala Ala Ser Gln Glu
    2450                2455                2460                
Gly Thr Met Asn Arg Gly Asp Phe Leu Leu Ser Val Asn Gly Ala Ser
2465                2470                2475                2480
Leu Ala Gly Leu Ala His Gly Asn Val Leu Lys Val Leu His Gln Ala
                2485                2490                2495    
Gln Leu His Lys Asp Ala Leu Val Val Ile Lys Lys Gly Met Asp Gln
            2500                2505                2510        
Pro Arg Pro Ser Ala Arg Gln Glu Pro Pro Thr Ala Asn Gly Lys Gly
        2515                2520                2525            
Leu Leu Ser Arg Lys Thr Ile Pro Leu Glu Pro Gly Ile Gly Arg Ser
    2530                2535                2540                
Val Ala Val His Asp Ala Leu Cys Val Glu Val Leu Lys Thr Ser Ala
2545                2550                2555                2560
Gly Leu Gly Leu Ser Leu Asp Gly Gly Lys Ser Ser Val Thr Gly Asp
                2565                2570                2575    
Gly Pro Leu Val Ile Lys Arg Val Tyr Lys Gly Gly Ala Ala Glu Gln
            2580                2585                2590        
Ala Gly Ile Ile Glu Ala Gly Asp Glu Ile Leu Ala Ile Asn Gly Lys
        2595                2600                2605            
Pro Leu Val Gly Leu Met His Phe Asp Ala Trp Asn Ile Met Lys Ser
    2610                2615                2620                
Val Pro Glu Gly Pro Val Gln Leu Leu Ile Arg Lys His Arg Asn Ser
2625                2630                2635                2640
Ser
    


<210> 7736
<211> 862
<212> PRT
<213> Homo sapiens

<400> 7736
Met Ala Glu Gln Arg Phe Cys Val Asp Tyr Ala Lys Arg Gly Thr Ala
 1               5                  10                  15      
Gly Cys Lys Lys Cys Lys Glu Lys Ile Val Lys Gly Val Cys Arg Ile
            20                  25                  30          
Gly Lys Val Val Pro Asn Pro Phe Ser Glu Ser Gly Gly Asp Met Lys
        35                  40                  45              
Glu Trp Tyr His Ile Lys Cys Met Phe Glu Lys Leu Glu Arg Ala Arg
    50                  55                  60                  
Ala Thr Thr Lys Lys Ile Glu Asp Leu Thr Glu Leu Glu Gly Trp Glu
65                  70                  75                  80  
Glu Leu Glu Asp Asn Glu Lys Glu Gln Ile Thr Gln His Ile Ala Asp
                85                  90                  95      
Leu Ser Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln
            100                 105                 110         
Ala Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala
        115                 120                 125             
Ser Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala
    130                 135                 140                 
Lys Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg
145                 150                 155                 160 
Ser Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu
                165                 170                 175     
Arg Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr
            180                 185                 190         
Asn Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala
        195                 200                 205             
Gly Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu
    210                 215                 220                 
Pro Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val
225                 230                 235                 240 
Lys Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg
                245                 250                 255     
Asp Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu
            260                 265                 270         
Gln Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln
        275                 280                 285             
Glu Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp
    290                 295                 300                 
Glu Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn
305                 310                 315                 320 
Asp Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn
                325                 330                 335     
Ser Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu
            340                 345                 350         
Ala Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu
        355                 360                 365             
His Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu
    370                 375                 380                 
Ser Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu
385                 390                 395                 400 
Ala Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met
                405                 410                 415     
Phe Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn
            420                 425                 430         
Gly Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro
        435                 440                 445             
His Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly
    450                 455                 460                 
Gly His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys
465                 470                 475                 480 
Thr Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala
                485                 490                 495     
Ala Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr
            500                 505                 510         
Phe Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys
        515                 520                 525             
Phe Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser
    530                 535                 540                 
Glu Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr
545                 550                 555                 560 
Arg Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys
                565                 570                 575     
Gly Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp
            580                 585                 590         
Tyr Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu
        595                 600                 605             
Gly Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe
    610                 615                 620                 
Leu Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr
625                 630                 635                 640 
Lys Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn
                645                 650                 655     
Glu Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser
            660                 665                 670         
Trp Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp
        675                 680                 685             
Pro Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys
    690                 695                 700                 
Ser Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys
705                 710                 715                 720 
Thr Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro
                725                 730                 735     
Gln Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr
            740                 745                 750         
Val Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu
        755                 760                 765             
Glu Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser
    770                 775                 780                 
Lys Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser
785                 790                 795                 800 
Asn Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys
                805                 810                 815     
Val Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu
            820                 825                 830         
Lys Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Arg Arg Pro
        835                 840                 845             
Ala Ser Glu Gln Arg Gly Arg Thr Val Pro Ala Gly Arg Arg
    850                 855                 860         


<210> 7737
<211> 299
<212> PRT
<213> Homo sapiens

<400> 7737
Met Ser Leu Ala Phe Lys Ile Phe Phe Pro Gln Thr Leu Arg Ala Leu
 1               5                  10                  15      
Ser Arg Lys Glu Leu Cys Leu Phe Arg Lys His His Trp Arg Asp Val
            20                  25                  30          
Arg Gln Phe Ser Gln Trp Ser Glu Thr Asp Leu Leu His Gly His Pro
        35                  40                  45              
Leu Phe Leu Arg Arg Lys Pro Val Leu Ser Phe Gln Gly Ser His Leu
    50                  55                  60                  
Arg Ser Arg Ala Thr Tyr Leu Val Phe Leu Pro Gly Leu His Val Gly
65                  70                  75                  80  
Leu Cys Ser Gly Pro Cys Glu Met Ala Glu Gln Arg Phe Cys Val Asp
                85                  90                  95      
Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys Cys Lys Glu Lys Ile
            100                 105                 110         
Val Lys Gly Val Cys Arg Ile Gly Lys Val Val Pro Asn Pro Phe Ser
        115                 120                 125             
Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His Ile Lys Cys Met Phe
    130                 135                 140                 
Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys Lys Ile Glu Asp Leu
145                 150                 155                 160 
Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp Asn Glu Lys Glu Gln
                165                 170                 175     
Ile Thr Gln His Ile Ala Asp Leu Ser Ser Lys Ala Ala Gly Thr Pro
            180                 185                 190         
Lys Lys Lys Ala Val Val Gln Ala Lys Leu Thr Thr Thr Gly Gln Val
        195                 200                 205             
Thr Ser Pro Val Lys Gly Ala Ser Phe Val Thr Ser Thr Asn Pro Arg
    210                 215                 220                 
Lys Phe Ser Gly Phe Ser Ala Lys Pro Asn Asn Ser Gly Glu Ala Pro
225                 230                 235                 240 
Ser Ser Pro Thr Pro Lys Arg Ser Leu Ser Ser Ser Lys Cys Asp Pro
                245                 250                 255     
Arg His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys Ala Met
            260                 265                 270         
Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile Gln Asp
        275                 280                 285             
Phe Leu Arg Lys Gly Ser Ala Gly Gly Val Ala
    290                 295                 


<210> 7738
<211> 922
<212> PRT
<213> Homo sapiens

<400> 7738
Met Ala Glu Gln Arg Phe Cys Val Asp Tyr Ala Lys Arg Gly Thr Ala
 1               5                  10                  15      
Gly Cys Lys Lys Cys Lys Glu Lys Ile Val Lys Gly Val Cys Arg Ile
            20                  25                  30          
Gly Lys Val Val Pro Asn Pro Phe Ser Glu Ser Gly Gly Asp Met Lys
        35                  40                  45              
Glu Trp Tyr His Ile Lys Cys Met Phe Glu Lys Leu Glu Arg Ala Arg
    50                  55                  60                  
Ala Thr Thr Lys Lys Ile Glu Asp Leu Thr Glu Leu Glu Gly Trp Glu
65                  70                  75                  80  
Glu Leu Glu Asp Asn Glu Lys Glu Gln Ile Thr Gln His Ile Ala Asp
                85                  90                  95      
Leu Ser Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln
            100                 105                 110         
Ala Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala
        115                 120                 125             
Ser Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala
    130                 135                 140                 
Lys Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg
145                 150                 155                 160 
Ser Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu
                165                 170                 175     
Arg Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr
            180                 185                 190         
Asn Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala
        195                 200                 205             
Gly Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu
    210                 215                 220                 
Pro Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val
225                 230                 235                 240 
Lys Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg
                245                 250                 255     
Asp Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu
            260                 265                 270         
Gln Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln
        275                 280                 285             
Glu Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp
    290                 295                 300                 
Glu Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn
305                 310                 315                 320 
Asp Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn
                325                 330                 335     
Ser Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu
            340                 345                 350         
Ala Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu
        355                 360                 365             
His Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu
    370                 375                 380                 
Ser Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu
385                 390                 395                 400 
Ala Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met
                405                 410                 415     
Phe Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn
            420                 425                 430         
Gly Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro
        435                 440                 445             
His Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly
    450                 455                 460                 
Gly His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys
465                 470                 475                 480 
Thr Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala
                485                 490                 495     
Ala Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr
            500                 505                 510         
Phe Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys
        515                 520                 525             
Phe Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser
    530                 535                 540                 
Glu Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr
545                 550                 555                 560 
Arg Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys
                565                 570                 575     
Gly Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp
            580                 585                 590         
Tyr Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu
        595                 600                 605             
Gly Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe
    610                 615                 620                 
Leu Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr
625                 630                 635                 640 
Lys Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn
                645                 650                 655     
Glu Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser
            660                 665                 670         
Trp Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp
        675                 680                 685             
Pro Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys
    690                 695                 700                 
Ser Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys
705                 710                 715                 720 
Thr Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro
                725                 730                 735     
Gln Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr
            740                 745                 750         
Val Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu
        755                 760                 765             
Glu Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser
    770                 775                 780                 
Lys Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser
785                 790                 795                 800 
Asn Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys
                805                 810                 815     
Val Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu
            820                 825                 830         
Lys Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Val Leu Leu
        835                 840                 845             
Asp Ile Phe Thr Gly Val Arg Leu Tyr Leu Pro Pro Ser Thr Pro Asp
    850                 855                 860                 
Phe Ser Arg Leu Arg Arg Tyr Phe Val Ala Phe Asp Gly Asp Leu Val
865                 870                 875                 880 
Gln Glu Phe Asp Met Thr Ser Ala Thr His Val Leu Gly Ser Arg Asp
                885                 890                 895     
Lys Asn Pro Ala Ala Gln Gln Val Ser Pro Glu Trp Ile Trp Ala Cys
            900                 905                 910         
Ile Arg Lys Arg Arg Leu Val Ala Pro Cys
        915                 920         


<210> 7739
<211> 1154
<212> PRT
<213> Homo sapiens

<400> 7739
Met Ser Asp Ala Ala Glu Ala Pro Arg Glu Ala Thr Gly Glu Asn Gly
 1               5                  10                  15      
Glu Thr Glu Met Lys Glu Glu Glu Glu Pro Asn Pro Asn Tyr Lys Glu
            20                  25                  30          
Val Glu Asp Pro Gln Gln Glu Ser Lys Asp Asp Thr Ile Ala Trp Arg
        35                  40                  45              
Glu Ser Gln Glu Glu Glu Arg Lys Thr Gly Glu Glu Glu Gly Glu Glu
    50                  55                  60                  
Glu Glu Lys Glu Glu Glu Gly Lys Glu Asp Lys Lys Ile Val Met Glu
65                  70                  75                  80  
Glu Thr Glu Glu Lys Ala Gly Glu Val Gln Glu Lys Glu Ala Ser Gly
                85                  90                  95      
Ile Gln Glu Glu Thr Thr Val Glu Pro Gln Glu Val Thr Ala Ser Met
            100                 105                 110         
Ile Arg Leu Glu Thr Gln Ile Thr Asp Ser Gln Ser Ile Thr Ser Gly
        115                 120                 125             
Ile Phe Pro Lys Thr Gln Arg Gly Ser Lys Ser Lys Leu Ser Leu Gln
    130                 135                 140                 
Leu Glu Asp Ala Glu Thr Asp Glu Leu Leu Arg Asp Leu Ser Thr Gln
145                 150                 155                 160 
Ile Glu Phe Leu Asp Leu Asp Gln Ile Ser Pro Glu Glu Gln Gln Ile
                165                 170                 175     
Ser Ser Pro Glu Arg Gln Pro Ser Gly Glu Leu Glu Glu Lys Thr Asp
            180                 185                 190         
Arg Met Pro Gln Asp Glu Leu Gly Gln Glu Arg Arg Asp Leu Glu Pro
        195                 200                 205             
Glu Asn Arg Glu Glu Gly Gln Glu Arg Arg Val Ser Asp Ile Gln Ser
    210                 215                 220                 
Lys Ala Gly Ile Ser Arg Glu Ser Leu Val Ser Ser Thr Thr Glu Asp
225                 230                 235                 240 
Ile Leu Phe Gln Lys Asp Lys Ser Thr Pro Val Tyr Pro Leu Thr Met
                245                 250                 255     
Thr Trp Ser Phe Gly Trp Asn Ser Ser Leu Pro Val Tyr Tyr Ile Arg
            260                 265                 270         
Glu Glu Arg Gln Arg Val Leu Leu Tyr Val Cys Ala His Thr Ala Ile
        275                 280                 285             
Ile Tyr Asn Val Phe Arg Asn Asn Gln Tyr His Leu Gln Gly His Ala
    290                 295                 300                 
Asn Ile Ile Ser Cys Leu Cys Val Ser Glu Asp Arg Arg Trp Ile Ala
305                 310                 315                 320 
Thr Ala Asp Lys Gly Pro Asp Cys Leu Val Ile Ile Trp Asp Ser Phe
                325                 330                 335     
Thr Gly Ile Pro Val His Thr Ile Phe Asp Ser Cys Pro Glu Gly Asn
            340                 345                 350         
Gly Ile Met Ala Met Ala Met Thr His Asp Ala Lys Tyr Leu Ala Thr
        355                 360                 365             
Ile Ser Asp Ala Glu Val Gln Lys Val Cys Ile Trp Lys Trp Thr Leu
    370                 375                 380                 
Ala Val Glu Thr Pro Ala Cys Thr Leu Glu Leu Pro Thr Glu Tyr Gly
385                 390                 395                 400 
Val Gln Asn Tyr Val Thr Phe Asn Pro Thr Asn Asn Lys Glu Leu Val
                405                 410                 415     
Ser Asn Ser Lys Thr Arg Ala Ile Tyr Tyr Ala Trp Tyr Glu Glu Arg
            420                 425                 430         
Asp Thr Leu Ala His Ser Ala Pro Leu Leu Thr Glu Lys Thr Phe Asn
        435                 440                 445             
Lys Leu Val Gly Lys Phe Ser Gln Ser Ile Phe His Leu Asn Leu Thr
    450                 455                 460                 
Gln Ile Leu Ser Ala Thr Met Glu Gly Lys Leu Val Val Trp Asp Ile
465                 470                 475                 480 
His Arg Pro Pro Ser Ser Ala Ser Thr Phe Leu Gly Phe Pro Tyr Ile
                485                 490                 495     
Lys Pro Cys Lys Leu Val His Leu Gln Lys Glu Gly Ile Thr Val Leu
            500                 505                 510         
Thr Thr Ile Asp Ser Tyr Ile Val Thr Gly Asp Ile Lys Gly Asn Ile
        515                 520                 525             
Lys Phe Tyr Asp His Thr Leu Ser Ile Val Asn Trp Tyr Ser His Leu
    530                 535                 540                 
Lys Leu Gly Ala Ile Arg Thr Leu Ser Phe Ser Lys Thr Pro Ala Thr
545                 550                 555                 560 
Pro Pro Thr Glu Lys Ser Asn Tyr Pro Pro Asp Cys Thr Leu Lys Gly
                565                 570                 575     
Asp Leu Phe Val Leu Arg Asn Phe Ile Ile Gly Thr Ser Asp Ala Ala
            580                 585                 590         
Val Tyr His Leu Thr Thr Asp Gly Thr Lys Leu Glu Lys Leu Phe Val
        595                 600                 605             
Glu Pro Lys Asp Ala Ile Cys Ala Ile Ser Cys His Pro Tyr Gln Pro
    610                 615                 620                 
Leu Ile Ala Ile Gly Ser Ile Cys Gly Met Ile Lys Val Trp Asn Tyr
625                 630                 635                 640 
Glu Asn Lys Gln Tyr Leu Phe Ser Arg Val Phe Glu Lys Gly Phe Gly
                645                 650                 655     
Val Gln Ser Leu Thr Tyr Asn Pro Glu Gly Ala Leu Leu Gly Ala Gly
            660                 665                 670         
Phe Thr Glu Gly Thr Val Tyr Ile Leu Asp Ala Met Ser Leu Glu Asn
        675                 680                 685             
Glu Ser Pro Glu Pro Phe Lys Tyr Ser Arg Thr Ser Val Thr His Ile
    690                 695                 700                 
Ser Phe Ser His Asp Ser Gln Tyr Met Ala Thr Ala Asp Arg Ser Phe
705                 710                 715                 720 
Thr Val Ala Val Tyr Met Leu Val Val Arg Asn Gly Gln Arg Val Trp
                725                 730                 735     
Glu Tyr Leu Ala Arg Leu Arg Ser His Arg Lys Ser Ile Arg Ser Leu
            740                 745                 750         
Leu Phe Gly Val Tyr Leu Asp Ser Asn Glu Pro Arg Leu Leu Ser Leu
        755                 760                 765             
Gly Thr Asp Arg Leu Leu Ile Glu Tyr Asp Leu Leu Arg Ser Tyr Lys
    770                 775                 780                 
Asp His Leu Glu Val Leu Asp Ile His His Thr Asp Gln Gly Cys Tyr
785                 790                 795                 800 
Pro Thr Cys Met Val Trp Tyr Pro Pro Leu Thr Arg Glu Leu Phe Leu
                805                 810                 815     
Leu Ile Cys Asn Ser Gly Tyr Lys Val Lys Leu Phe Asn Ala Thr Thr
            820                 825                 830         
Lys Met Cys Arg Lys Thr Leu Leu Gly Pro Ala Tyr Gly Ser Pro Ile
        835                 840                 845             
Glu Gln Thr Gln Val Leu Pro Val Arg Ser Met Ala Glu Leu Gln Lys
    850                 855                 860                 
Arg Tyr Leu Val Phe Ile Asn Arg Asp Lys Leu Gly Leu Gln Ile Leu
865                 870                 875                 880 
Pro Val Asp Gly Asn Pro His Lys Thr Ser Ala Ile Val Cys His Pro
                885                 890                 895     
Asn Gly Val Ala Gly Met Ala Val Ser Tyr Asp Gly Cys Tyr Ala Phe
            900                 905                 910         
Thr Ala Gly Gly His Asp Arg Ser Val Val Gln Trp Lys Ile Thr Leu
        915                 920                 925             
Ser Val Leu Glu Ala Ala Val Ser Leu Gly Gly Glu Asp Leu Thr Pro
    930                 935                 940                 
Phe Tyr Gly Leu Leu Ser Gly Gly Arg Glu Gly Lys Phe Tyr Arg Glu
945                 950                 955                 960 
Leu Glu Asp Tyr Phe Tyr Tyr Ser Gln Leu Arg Ser Gln Gly Ile Asp
                965                 970                 975     
Thr Met Glu Thr Arg Lys Val Ser Glu His Ile Cys Leu Ser Glu Leu
            980                 985                 990         
Pro Phe Val Met Arg Ala Ile Gly Phe Tyr Pro Ser Glu Glu Lys Ile
        995                 1000                1005            
Asp Asp Ile Phe Asn Glu Ile Lys Phe Gly Glu Tyr Val Asp Thr Gly
    1010                1015                1020                
Lys Leu Ile Asp Lys Ile Asn Leu Pro Asp Phe Leu Lys Val Tyr Leu
1025                1030                1035                1040
Asn His Lys Pro Pro Phe Gly Asn Thr Met Ser Gly Ile His Lys Ser
                1045                1050                1055    
Phe Glu Val Leu Gly Tyr Thr Asn Ser Lys Gly Lys Lys Ala Ile Arg
            1060                1065                1070        
Arg Glu Asp Phe Leu Arg Leu Leu Val Thr Lys Gly Glu His Met Thr
        1075                1080                1085            
Glu Glu Glu Met Leu Asp Cys Phe Ala Ser Leu Phe Gly Leu Asn Pro
    1090                1095                1100                
Glu Gly Trp Lys Ser Glu Pro Ala Thr Cys Ser Val Lys Gly Ser Glu
1105                1110                1115                1120
Ile Cys Leu Glu Glu Glu Leu Pro Asp Glu Ile Thr Ala Glu Ile Phe
                1125                1130                1135    
Ala Thr Glu Ile Leu Gly Leu Thr Ile Ser Glu Asp Ser Gly Gln Asp
            1140                1145                1150        
Gly Gln
        


<210> 7740
<211> 297
<212> PRT
<213> Homo sapiens

<400> 7740
Met Glu Glu Thr Glu Glu Lys Ala Gly Glu Val Gln Glu Lys Glu Ala
 1               5                  10                  15      
Ser Gly Ile Gln Glu Glu Thr Thr Val Glu Pro Gln Glu Val Thr Ala
            20                  25                  30          
Ser Met Ile Arg Leu Glu Thr Gln Ile Thr Asp Ser Gln Ser Ile Thr
        35                  40                  45              
Ser Gly Ile Phe Pro Lys Thr Gln Arg Gly Ser Lys Ser Lys Leu Ser
    50                  55                  60                  
Leu Gln Leu Glu Asp Ala Glu Thr Asp Glu Leu Leu Arg Asp Leu Ser
65                  70                  75                  80  
Thr Gln Ile Glu Phe Leu Asp Leu Asp Gln Ile Ser Pro Glu Glu Gln
                85                  90                  95      
Gln Ile Ser Ser Pro Glu Arg Gln Pro Ser Gly Glu Leu Glu Glu Lys
            100                 105                 110         
Thr Asp Arg Ile Pro Gln Asp Glu Leu Gly Gln Glu Arg Arg Asp Leu
        115                 120                 125             
Glu Pro Glu Asn Arg Glu Glu Gly Gln Glu Arg Arg Val Ser Asp Ile
    130                 135                 140                 
Gln Ser Lys Ala Gly Ile Ser Arg Glu Ser Leu Val Ser Ser Thr Thr
145                 150                 155                 160 
Glu Asp Ile Leu Phe Gln Lys Asp Lys Ser Thr Pro Val Tyr Pro Leu
                165                 170                 175     
Thr Met Thr Trp Ser Phe Gly Trp Asn Ser Ser Leu Pro Val Tyr Tyr
            180                 185                 190         
Ile Arg Glu Glu Arg Gln Arg Val Leu Leu Tyr Val Cys Ala His Thr
        195                 200                 205             
Ala Ile Ile Tyr Asn Val Phe Arg Asn Asn Gln Tyr His Leu Gln Val
    210                 215                 220                 
Cys Arg Asp Phe Leu Pro Thr Gly Gly Gly Val Val Phe Asn Val Arg
225                 230                 235                 240 
Val Val Phe Cys Phe Val Ser Gln Gly Leu Thr Ser Phe Tyr His Cys
                245                 250                 255     
Arg Ile Phe Pro Leu Ser Leu Glu Leu Lys Ala Ser Leu Ser Leu Glu
            260                 265                 270         
Thr His Gly Ile Val Tyr Cys Leu Ser Val Ser Asn Gln Asn Gln Leu
        275                 280                 285             
Thr Lys Gln Gln Leu Ile Leu Ile Leu
    290                 295         


<210> 7741
<211> 134
<212> PRT
<213> Homo sapiens

<400> 7741
Met Thr Arg Asp Gln Asn Gly Thr Trp Glu Met Glu Ser Asn Glu Asn
 1               5                  10                  15      
Phe Glu Gly Tyr Met Lys Ala Leu Asp Ile Asp Phe Ala Thr Arg Lys
            20                  25                  30          
Ile Ala Val Arg Leu Thr Gln Thr Lys Val Ile Asp Gln Asp Gly Asp
        35                  40                  45              
Asn Phe Lys Thr Lys Thr Thr Ser Thr Phe Arg Asn Tyr Asp Val Asp
    50                  55                  60                  
Phe Thr Val Gly Val Glu Phe Asp Glu Tyr Thr Lys Ser Leu Asp Asn
65                  70                  75                  80  
Arg His Val Lys Ala Leu Val Thr Trp Glu Gly Asp Val Leu Val Cys
                85                  90                  95      
Val Gln Lys Gly Glu Lys Glu Asn Arg Gly Trp Lys Gln Trp Ile Glu
            100                 105                 110         
Gly Asp Lys Leu Tyr Leu Glu Leu Thr Cys Gly Asp Gln Val Cys Arg
        115                 120                 125             
Gln Val Phe Lys Lys Lys
    130                 


<210> 7742
<211> 766
<212> PRT
<213> Homo sapiens

<400> 7742
Met Thr Asn Gly Thr Leu Glu Pro Ala Ala Glu Trp Ser Val Leu Leu
 1               5                  10                  15      
Gly Val His Ser Gln Asp Gly Pro Leu Asp Gly Ala His Thr Arg Ala
            20                  25                  30          
Val Ala Ala Ile Val Val Pro Ala Asn Tyr Ser Gln Val Glu Leu Gly
        35                  40                  45              
Ala Asp Leu Ala Leu Leu Arg Leu Ala Ser Pro Ala Ser Leu Gly Pro
    50                  55                  60                  
Ala Val Trp Pro Val Cys Leu Pro Arg Ala Ser His Arg Phe Val His
65                  70                  75                  80  
Gly Thr Ala Cys Trp Ala Thr Gly Trp Gly Asp Val Gln Glu Ala Asp
                85                  90                  95      
Pro Leu Pro Leu Pro Trp Val Leu Gln Glu Val Glu Leu Arg Leu Leu
            100                 105                 110         
Gly Glu Ala Thr Cys Gln Cys Leu Tyr Ser Gln Pro Gly Pro Phe Asn
        115                 120                 125             
Leu Thr Leu Gln Ile Leu Pro Gly Met Leu Cys Ala Gly Tyr Pro Glu
    130                 135                 140                 
Gly Arg Arg Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys
145                 150                 155                 160 
Glu Glu Gly Gly Arg Trp Phe Gln Ala Gly Ile Thr Ser Phe Gly Phe
                165                 170                 175     
Gly Cys Gly Arg Arg Asn Arg Pro Gly Val Phe Thr Ala Val Ala Thr
            180                 185                 190         
Tyr Glu Ala Trp Ile Arg Glu Gln Val Met Gly Ser Glu Pro Gly Pro
        195                 200                 205             
Ala Phe Pro Thr Gln Pro Gln Lys Thr Gln Ser Asp Pro Gln Glu Pro
    210                 215                 220                 
Arg Glu Glu Asn Cys Thr Ile Ala Leu Pro Glu Cys Gly Lys Ala Pro
225                 230                 235                 240 
Arg Pro Gly Ala Trp Pro Trp Glu Ala Gln Val Met Val Pro Gly Ser
                245                 250                 255     
Arg Pro Cys His Gly Ala Leu Val Ser Glu Ser Trp Val Leu Ala Pro
            260                 265                 270         
Ala Ser Cys Phe Leu Asp Pro Asn Ser Ser Asp Ser Pro Pro Arg Asp
        275                 280                 285             
Leu Asp Ala Trp Arg Val Leu Leu Pro Ser Arg Pro Arg Ala Glu Arg
    290                 295                 300                 
Val Ala Arg Leu Val Gln His Glu Asn Ala Ser Trp Asp Asn Ala Ser
305                 310                 315                 320 
Asp Leu Ala Leu Leu Gln Leu Arg Thr Pro Val Asn Leu Ser Ala Ala
                325                 330                 335     
Ser Arg Pro Val Cys Leu Pro His Pro Glu His Tyr Phe Leu Pro Gly
            340                 345                 350         
Ser Arg Cys Arg Leu Ala Arg Trp Gly Arg Gly Glu Pro Ala Leu Gly
        355                 360                 365             
Pro Gly Ala Leu Leu Glu Ala Glu Leu Leu Gly Gly Trp Trp Cys His
    370                 375                 380                 
Cys Leu Tyr Gly Arg Gln Gly Ala Ala Val Pro Leu Pro Gly Asp Pro
385                 390                 395                 400 
Pro His Ala Leu Cys Pro Ala Tyr Gln Glu Lys Glu Glu Val Gly Ser
                405                 410                 415     
Cys Trp Asn Asp Ser Arg Trp Ser Leu Leu Cys Gln Glu Glu Gly Thr
            420                 425                 430         
Trp Phe Leu Ala Gly Ile Arg Asp Phe Pro Ser Gly Cys Leu Arg Pro
        435                 440                 445             
Arg Ala Phe Phe Pro Leu Gln Thr His Gly Pro Trp Ile Ser His Val
    450                 455                 460                 
Thr Arg Gly Ala Tyr Leu Glu Asp Gln Leu Ala Trp Asp Trp Gly Pro
465                 470                 475                 480 
Asp Gly Glu Glu Thr Glu Thr Gln Thr Cys Pro Pro His Thr Glu His
                485                 490                 495     
Gly Ala Cys Gly Leu Arg Leu Glu Ala Ala Pro Val Gly Val Leu Trp
            500                 505                 510         
Pro Trp Leu Ala Glu Val His Val Ala Gly Asp Arg Val Cys Thr Gly
        515                 520                 525             
Ile Leu Leu Ala Pro Gly Trp Val Leu Ala Ala Thr His Cys Val Leu
    530                 535                 540                 
Arg Pro Gly Ser Thr Thr Val Pro Tyr Ile Glu Val Tyr Leu Gly Arg
545                 550                 555                 560 
Ala Gly Ala Ser Ser Leu Pro Gln Gly His Gln Val Ser Arg Leu Val
                565                 570                 575     
Ile Ser Ile Arg Leu Pro Gln His Leu Gly Leu Arg Pro Pro Leu Ala
            580                 585                 590         
Leu Leu Glu Leu Ser Ser Arg Val Glu Pro Ser Pro Ser Ala Leu Pro
        595                 600                 605             
Ile Cys Leu His Pro Ala Gly Ile Pro Pro Gly Ala Ser Cys Trp Val
    610                 615                 620                 
Leu Gly Trp Lys Glu Pro Gln Asp Arg Val Pro Val Ala Ala Ala Val
625                 630                 635                 640 
Ser Ile Leu Thr Gln Arg Ile Cys Asp Cys Leu Tyr Gln Gly Ile Leu
                645                 650                 655     
Pro Pro Gly Thr Leu Cys Val Leu Tyr Ala Glu Gly Gln Glu Asn Arg
            660                 665                 670         
Cys Glu Met Thr Ser Ala Pro Pro Leu Leu Cys Gln Met Thr Glu Gly
        675                 680                 685             
Ser Trp Ile Leu Val Gly Met Ala Val Gln Gly Ser Arg Glu Leu Phe
    690                 695                 700                 
Ala Ala Ile Gly Pro Glu Glu Ala Trp Ile Ser Gln Thr Val Gly Glu
705                 710                 715                 720 
Ala Asn Leu Leu Pro Pro Ser Gly Ser Pro His Trp Pro Thr Gly Gly
                725                 730                 735     
Ser Asn Leu Cys Pro Pro Glu Leu Ala Lys Ala Ser Gly Ser Pro His
            740                 745                 750         
Ala Val Tyr Phe Leu Leu Leu Leu Thr Leu Leu Ile Gln Ser
        755                 760                 765     


<210> 7743
<211> 696
<212> PRT
<213> Homo sapiens

<400> 7743
Met Thr Asp Pro Met Met Asp Phe Phe Asp Asp Ala Asn Leu Phe Gly
 1               5                  10                  15      
Glu Thr Leu Glu Gly Leu Ser Asp Asp Ala Phe Val Gln Pro Gly Pro
            20                  25                  30          
Val Ser Leu Val Asp Glu Leu Asn Leu Gly Ala Glu Phe Glu Pro Leu
        35                  40                  45              
His Ile Asp Ser Leu Asn His Val Gln Gly Thr Pro Thr His Gln Lys
    50                  55                  60                  
Met Thr Asp Phe Glu Gln Leu Asn Gln Phe Asp Ser Ile Lys Phe His
65                  70                  75                  80  
His Val Asn Gln Ser Phe Gly Ser Pro Ala Glu His Val Leu Ser Pro
                85                  90                  95      
His Ser Gln Phe Asn Cys Ser Pro Ile His Pro Gln Asn Gln Pro Asn
            100                 105                 110         
Gly Leu Phe Pro Asp Val Ser Asp Gly Ser Pro Met Trp Gly His Gln
        115                 120                 125             
Thr Ala Thr Thr Ile Ser Asn Gln Asn Gly Ser Pro Phe His Gln Gln
    130                 135                 140                 
Gly His Ser His Ser Met His Gln Asn Lys Ser Phe Val Ala His His
145                 150                 155                 160 
Asp Phe Ala Leu Phe Gln Ala Asn Glu Gln Gln Thr Gln Cys Thr Ser
                165                 170                 175     
Leu Arg Ser Gln Gln Asn Arg Asn Asn Leu Asn Pro Gly Gln Asn Ser
            180                 185                 190         
Leu Ser Gln Ser Lys Asn Phe Met Asn Val Ser Gly Pro His Arg Val
        195                 200                 205             
Asn Val Asn His Pro Pro Gln Met Thr Asn Ala Ser Asn Ser Gln Gln
    210                 215                 220                 
Ser Ile Ser Met Gln Gln Phe Ser Gln Thr Ser Asn Pro Ser Ala His
225                 230                 235                 240 
Phe His Lys Cys Ser Ser His Gln Glu Gly Asn Phe Asn Gly Pro Ser
                245                 250                 255     
Pro Asn Met Thr Ser Cys Ser Val Ser Asn Ser Gln Gln Phe Ser Ser
            260                 265                 270         
His Tyr Ser Phe Ser Ser Asn His Ile Ser Pro Asn Ser Leu Leu Gln
        275                 280                 285             
Ser Ser Ala Val Leu Ala Ser Asn His Thr Asn Gln Thr Leu Ser Asp
    290                 295                 300                 
Phe Thr Gly Ser Asn Ser Phe Ser Pro His Arg Gly Ile Lys Gln Glu
305                 310                 315                 320 
Ser Thr Gln His Ile Leu Asn Pro Asn Thr Ser Leu Asn Ser Asn Asn
                325                 330                 335     
Phe Gln Ile Leu His Ser Ser His Pro Gln Gly Asn Tyr Ser Asn Ser
            340                 345                 350         
Lys Leu Ser Pro Val His Met Asn Phe Pro Asp Pro Val Asp Ser Gly
        355                 360                 365             
Thr Gln Met Gly His Phe Asn Asp His Val Glu Thr Asn Gly Phe Ser
    370                 375                 380                 
Ser Leu Glu Glu Asn Leu Leu His Gln Val Glu Ser Gln Thr Glu Pro
385                 390                 395                 400 
Phe Thr Gly Leu Asp Pro Glu Asp Leu Leu Gln Glu Gly Leu Leu Pro
                405                 410                 415     
His Phe Asp Glu Ser Thr Phe Gly Gln Asp Asn Ser Ser His Ile Leu
            420                 425                 430         
Asp His Asp Leu Asp Arg Gln Phe Thr Ser His Leu Val Thr Arg Pro
        435                 440                 445             
Ser Asp Met Ala Gln Thr Gln Leu Gln Ser Gln Ala Arg Ser Trp His
    450                 455                 460                 
Ser Ser Phe Ser Asn His Gln His Leu His Asp Arg Asn His Leu Cys
465                 470                 475                 480 
Leu Gln Arg Gln Pro Pro Ser Ser Lys Lys Ser Asp Gly Ser Gly Thr
                485                 490                 495     
Tyr Thr Lys Leu Gln Asn Thr Gln Val Arg Val Met Ser Glu Lys Lys
            500                 505                 510         
Gln Arg Lys Lys Val Glu Ser Glu Ser Lys Gln Glu Lys Ala Asn Arg
        515                 520                 525             
Ile Ile Ser Glu Ala Ile Ala Lys Ala Lys Glu Arg Gly Glu Arg Asn
    530                 535                 540                 
Ile Pro Arg Val Met Ser Pro Glu Asn Phe Pro Thr Ala Ser Val Glu
545                 550                 555                 560 
Gly Lys Glu Glu Lys Lys Gly Arg Arg Met Lys Ser Lys Pro Lys Asp
                565                 570                 575     
Lys Asp Ser Lys Lys Thr Lys Thr Cys Ser Lys Leu Lys Glu Lys Thr
            580                 585                 590         
Lys Ile Gly Lys Leu Ile Ile Thr Leu Gly Lys Lys Gln Lys Arg Lys
        595                 600                 605             
Asn Glu Ser Ser Asp Glu Ile Ser Asp Ala Glu Gln Met Pro Gln His
    610                 615                 620                 
Thr Leu Lys Asp Gln Asp Ser Gln Lys Arg Arg Ser Asn Arg Gln Ile
625                 630                 635                 640 
Lys Arg Lys Lys Tyr Ala Glu Asp Ile Glu Gly Lys Gln Ser Glu Glu
                645                 650                 655     
Glu Val Lys Gly Ser Met Lys Ile Lys Lys Asn Ser Ala Pro Leu Pro
            660                 665                 670         
Gly Glu Gln Pro Leu Gln Leu Phe Val Val Ser Ile Phe Gly Ile Met
        675                 680                 685             
Thr Ala Lys His Phe Lys Pro Thr
    690                 695     


<210> 7744
<211> 297
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 270
<223> Xaa = Any Amino Acid

<400> 7744
Met Asp Thr Gly Ser Lys Asn Lys Val Ser Leu Asp Ile Cys Ile His
 1               5                  10                  15      
Gln Asn Thr Ala Trp Asn Ser Glu Arg Val Met Leu Glu Pro Gly Pro
            20                  25                  30          
Thr Ala Lys Ile Leu Trp His Cys Ala Val Glu Glu Thr Glu Pro Gln
        35                  40                  45              
Pro Ala Thr Gly Cys Ala Ser Phe Pro Ala Glu Ala Gln Leu Leu Gly
    50                  55                  60                  
Tyr Phe Ser Gly Ala Ala Val Arg Gln Ser Gly Gly Gln Gly Ser Asp
65                  70                  75                  80  
Ala Leu Pro Trp Gly Arg Ala Ala Tyr Gly Gly Arg Lys Gln Arg Gln
                85                  90                  95      
Trp Arg His Ser Glu Val Leu Asp Gly Gly Ser Ser Glu Glu Tyr Gln
            100                 105                 110         
Gly Gly Lys Arg His Asp Gln Lys Ser Pro Ser Leu Val Pro Pro Pro
        115                 120                 125             
Leu Glu Val Ser Lys Leu Thr Lys Gln Met Phe Asp Ala Lys Asn Met
    130                 135                 140                 
Leu Ala Ala Cys Asp Pro Cys His Gly Cys Tyr Leu Met Ala Ala Pro
145                 150                 155                 160 
Ile Val Gly Gly Cys Met Ser Met Arg Glu Val Asp Glu Gln Thr Tyr
                165                 170                 175     
Asn Ile Gln Asn Lys Tyr Ser Ser Tyr Phe Ala His Trp Ile Pro His
            180                 185                 190         
Asn Val Glu Arg Ala Ala Cys Asp Ile Pro Pro Leu Glu Leu Lys Met
        195                 200                 205             
Ser Val Thr Phe Ile Ser Asn Asn Thr Ala Ile Gln Glu Leu Phe Arg
    210                 215                 220                 
Phe Arg Cys Ile Leu Glu Gln Phe Thr Ala Lys Phe Arg Cys Lys Ala
225                 230                 235                 240 
Phe Leu Ser Trp Tyr Ser Gly Lys Gly Met His Asp Val Glu Phe Ala
                245                 250                 255     
Glu Val Glu Ser Asn Met Asn Asn Leu Val Ser Glu Tyr Xaa Gln Tyr
            260                 265                 270         
Gln Asp Thr Ile Gln Arg Arg Arg Glu Ser Leu Arg Ser Gly Pro Arg
        275                 280                 285             
Lys Arg Trp Leu Arg Pro Phe Cys Tyr
    290                 295         


<210> 7745
<211> 525
<212> PRT
<213> Homo sapiens

<400> 7745
Met Ser Trp His Pro Gln Tyr Arg Ser Ser Lys Phe Arg His Val Phe
 1               5                  10                  15      
Gly Lys Pro Ala Ser Lys Glu Asn Cys Tyr Asp Ser Val Pro Ile Thr
            20                  25                  30          
Arg Ser Val His Asp Asn His Phe Cys Ala Val Asn Pro His Phe Ile
        35                  40                  45              
Ala Val Val Thr Glu Cys Ala Gly Gly Gly Ala Phe Leu Val Ile Pro
    50                  55                  60                  
Leu His Gln Thr Gly Lys Leu Asp Pro His Tyr Pro Lys Val Cys Gly
65                  70                  75                  80  
His Arg Gly Asn Val Leu Asp Val Lys Trp Asn Pro Phe Asp Asp Phe
                85                  90                  95      
Glu Ile Ala Ser Cys Ser Glu Asp Ala Thr Ile Lys Ile Trp Ser Ile
            100                 105                 110         
Pro Lys Gln Leu Leu Thr Arg Asn Leu Thr Ala Tyr Arg Lys Glu Leu
        115                 120                 125             
Val Gly His Ala Arg Arg Val Gly Leu Val Glu Trp His Pro Thr Ala
    130                 135                 140                 
Ala Asn Ile Leu Phe Ser Ala Gly Tyr Asp Tyr Lys Val Met Ile Trp
145                 150                 155                 160 
Asn Leu Asp Thr Lys Glu Ser Val Ile Thr Ser Pro Met Ser Thr Ile
                165                 170                 175     
Ser Cys His Gln Asp Val Ile Leu Ser Met Ser Phe Asn Thr Asn Gly
            180                 185                 190         
Ser Leu Leu Ala Thr Thr Cys Lys Asp Arg Lys Ile Arg Val Ile Asp
        195                 200                 205             
Pro Arg Ala Gly Thr Val Leu Gln Glu Ala Ser Tyr Lys Gly His Arg
    210                 215                 220                 
Ala Ser Lys Val Leu Phe Leu Gly Asn Leu Lys Lys Leu Met Ser Thr
225                 230                 235                 240 
Gly Thr Ser Arg Trp Asn Asn Arg Gln Val Ala Leu Trp Asp Gln Asp
                245                 250                 255     
Asn Leu Ser Val Pro Leu Met Glu Glu Asp Leu Asp Gly Ser Ser Gly
            260                 265                 270         
Val Leu Phe Pro Phe Tyr Asp Ala Asp Thr Ser Met Leu Tyr Val Val
        275                 280                 285             
Gly Lys Gly Asp Gly Asn Ile Arg Tyr Tyr Glu Val Ser Ala Asp Lys
    290                 295                 300                 
Pro His Leu Ser Tyr Leu Thr Glu Tyr Arg Ser Tyr Asn Pro Gln Lys
305                 310                 315                 320 
Gly Ile Gly Val Met Pro Lys Arg Gly Leu Asp Val Ser Ser Cys Glu
                325                 330                 335     
Ile Phe Arg Phe Tyr Lys Leu Ile Thr Thr Lys Ser Leu Ile Glu Pro
            340                 345                 350         
Ile Ser Met Ile Val Pro Arg Gln Ser Glu Ser Tyr Gln Glu Asp Ile
        355                 360                 365             
Tyr Pro Pro Thr Ala Gly Ala Gln Pro Ser Leu Thr Ala Gln Glu Trp
    370                 375                 380                 
Leu Ser Gly Met Asn Arg Asp Pro Ile Leu Val Ser Leu Arg Pro Gly
385                 390                 395                 400 
Ser Glu Leu Leu Arg Pro His Pro Leu Pro Ala Glu Arg Pro Ile Phe
                405                 410                 415     
Asn Ser Met Ala Pro Ala Ser Pro Arg Leu Leu Asn Gln Thr Glu Lys
            420                 425                 430         
Leu Ala Ala Glu Asp Gly Trp Arg Ser Ser Ser Leu Leu Glu Glu Lys
        435                 440                 445             
Met Pro Arg Trp Ala Ala Glu His Arg Leu Glu Glu Lys Lys Thr Trp
    450                 455                 460                 
Leu Thr Asn Gly Phe Asp Val Phe Glu Cys Pro Pro Pro Lys Thr Glu
465                 470                 475                 480 
Asn Glu Leu Leu Gln Met Phe Tyr Arg Gln Gln Glu Glu Ile Arg Arg
                485                 490                 495     
Leu Arg Glu Leu Leu Thr Gln Arg Glu Val Gln Ala Lys Gln Leu Glu
            500                 505                 510         
Leu Glu Ile Lys Asn Leu Arg Met Gly Ser Glu Gln Leu
        515                 520                 525 


<210> 7746
<211> 525
<212> PRT
<213> Homo sapiens

<400> 7746
Met Ser Trp His Pro Gln Tyr Arg Ser Ser Lys Phe Arg His Val Phe
 1               5                  10                  15      
Gly Lys Pro Ala Ser Lys Glu Asn Cys Tyr Asp Ser Val Pro Ile Thr
            20                  25                  30          
Arg Ser Val His Asp Asn His Phe Cys Ala Val Asn Pro His Phe Ile
        35                  40                  45              
Ala Val Val Thr Glu Cys Ala Gly Gly Gly Ala Phe Leu Val Ile Pro
    50                  55                  60                  
Leu His Gln Thr Gly Lys Leu Asp Pro His Tyr Pro Lys Val Cys Gly
65                  70                  75                  80  
His Arg Gly Asn Val Leu Asp Val Lys Trp Asn Pro Phe Asp Asp Phe
                85                  90                  95      
Glu Ile Ala Ser Cys Ser Glu Asp Ala Thr Ile Lys Ile Trp Ser Ile
            100                 105                 110         
Pro Lys Gln Leu Leu Thr Arg Asn Leu Thr Ala Tyr Arg Lys Glu Leu
        115                 120                 125             
Val Gly His Ala Arg Arg Val Gly Leu Val Glu Trp His Pro Thr Ala
    130                 135                 140                 
Ala Asn Ile Leu Phe Ser Ala Gly Tyr Asp Tyr Lys Val Met Ile Trp
145                 150                 155                 160 
Asn Leu Asp Thr Lys Glu Ser Val Ile Thr Ser Pro Met Ser Thr Ile
                165                 170                 175     
Ser Cys His Gln Asp Val Ile Leu Ser Met Ser Phe Asn Thr Asn Gly
            180                 185                 190         
Ser Leu Leu Ala Thr Thr Cys Lys Asp Arg Lys Ile Arg Val Ile Asp
        195                 200                 205             
Pro Arg Ala Gly Thr Val Leu Gln Glu Ala Ser Tyr Lys Gly His Arg
    210                 215                 220                 
Ala Ser Lys Val Leu Phe Leu Gly Asn Leu Lys Lys Leu Met Ser Thr
225                 230                 235                 240 
Gly Thr Ser Arg Trp Asn Asn Arg Gln Val Ala Leu Trp Asp Gln Asp
                245                 250                 255     
Asn Leu Ser Val Pro Leu Met Glu Glu Asp Leu Asp Gly Ser Ser Gly
            260                 265                 270         
Val Leu Phe Pro Phe Tyr Asp Ala Asp Thr Ser Met Leu Tyr Val Val
        275                 280                 285             
Gly Lys Gly Asp Gly Asn Ile Arg Tyr Tyr Glu Val Ser Ala Asp Lys
    290                 295                 300                 
Pro His Leu Ser Tyr Leu Thr Glu Tyr Arg Ser Tyr Asn Pro Gln Lys
305                 310                 315                 320 
Gly Ile Gly Val Met Pro Lys Arg Gly Leu Asp Val Ser Ser Cys Glu
                325                 330                 335     
Ile Phe Arg Phe Tyr Lys Leu Ile Thr Thr Lys Ser Leu Ile Glu Pro
            340                 345                 350         
Ile Ser Met Ile Val Pro Arg Arg Ser Glu Ser Tyr Gln Glu Asp Ile
        355                 360                 365             
Tyr Pro Pro Thr Ala Gly Ala Gln Pro Ser Leu Thr Ala Gln Glu Trp
    370                 375                 380                 
Leu Ser Gly Met Asn Arg Asp Pro Ile Leu Val Ser Leu Arg Pro Gly
385                 390                 395                 400 
Ser Glu Leu Leu Arg Pro His Pro Leu Pro Ala Glu Arg Pro Ile Phe
                405                 410                 415     
Asn Ser Met Ala Pro Ala Ser Pro Arg Leu Leu Asn Gln Thr Glu Lys
            420                 425                 430         
Leu Ala Ala Glu Asp Gly Trp Arg Ser Ser Ser Leu Leu Glu Glu Lys
        435                 440                 445             
Met Pro Arg Trp Ala Ala Glu His Arg Leu Glu Glu Lys Lys Thr Trp
    450                 455                 460                 
Leu Thr Asn Gly Phe Asp Val Phe Glu Cys Pro Pro Pro Lys Thr Glu
465                 470                 475                 480 
Asn Glu Leu Leu Gln Met Phe Tyr Arg Gln Gln Glu Glu Ile Arg Arg
                485                 490                 495     
Leu Arg Glu Leu Leu Thr Gln Arg Glu Val Gln Ala Lys Gln Leu Glu
            500                 505                 510         
Leu Glu Ile Lys Asn Leu Arg Met Gly Ser Glu Gln Leu
        515                 520                 525 


<210> 7747
<211> 322
<212> PRT
<213> Homo sapiens

<400> 7747
Met Ser Ser Leu Gly Gly Gly Ser Gln Asp Ala Gly Gly Ser Ser Ser
 1               5                  10                  15      
Ser Ser Thr Asn Gly Ser Gly Gly Ser Gly Ser Ser Gly Pro Lys Ala
            20                  25                  30          
Gly Ala Ala Asp Lys Ser Ala Val Val Ala Ala Ala Ala Pro Ala Ser
        35                  40                  45              
Val Ala Asp Asp Thr Pro Pro Pro Glu Arg Arg Asn Lys Ser Gly Ile
    50                  55                  60                  
Ile Ser Glu Pro Leu Asn Lys Ser Leu Arg Arg Ser Arg Pro Leu Ser
65                  70                  75                  80  
His Tyr Ser Ser Phe Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Met
                85                  90                  95      
Met Gly Gly Glu Ser Ala Asp Lys Ala Thr Ala Ala Ala Ala Ala Ala
            100                 105                 110         
Ser Leu Leu Ala Asn Gly His Asp Leu Ala Ala Ala Met Ala Val Asp
        115                 120                 125             
Lys Ser Asn Pro Thr Ser Lys His Lys Ser Gly Ala Val Ala Ser Leu
    130                 135                 140                 
Leu Ser Lys Ala Glu Arg Ala Thr Glu Leu Ala Ala Glu Gly Gln Leu
145                 150                 155                 160 
Thr Leu Gln Gln Phe Ala Gln Ser Thr Glu Met Leu Lys Arg Val Val
                165                 170                 175     
Gln Glu His Leu Pro Leu Met Ser Glu Ala Gly Ala Gly Leu Pro Asp
            180                 185                 190         
Met Glu Ala Val Ala Gly Ala Glu Ala Leu Asn Gly Gln Ser Asp Phe
        195                 200                 205             
Pro Tyr Leu Gly Ala Phe Pro Ile Asn Pro Gly Leu Phe Ile Met Thr
    210                 215                 220                 
Pro Ala Gly Val Phe Leu Ala Glu Ser Ala Leu His Met Ala Gly Leu
225                 230                 235                 240 
Ala Glu Tyr Pro Met Gln Gly Glu Leu Ala Ser Ala Ile Ser Ser Gly
                245                 250                 255     
Lys Lys Lys Arg Lys Arg Cys Gly Met Cys Ala Pro Cys Arg Arg Arg
            260                 265                 270         
Ile Asn Cys Glu Gln Cys Ser Ser Cys Arg Asn Arg Lys Thr Gly His
        275                 280                 285             
Gln Ile Cys Lys Phe Arg Lys Cys Glu Glu Leu Lys Lys Lys Pro Ser
    290                 295                 300                 
Ala Ala Leu Glu Lys Val Met Leu Pro Thr Gly Ala Ala Phe Arg Trp
305                 310                 315                 320 
Phe Gln
        


<210> 7748
<211> 199
<212> PRT
<213> Homo sapiens

<400> 7748
Met Val Leu Leu His Met Lys Trp Gly Asp Lys Ser Gln Phe Leu Leu
 1               5                  10                  15      
Gln Val Pro Gly Ser Thr Lys Pro Glu Glu Leu Met Val Gln Val Gly
            20                  25                  30          
Gln Val Tyr Asn Gly Trp Leu Asn Val Gln Arg Leu Cys Leu Glu Met
        35                  40                  45              
Glu Glu Leu Ala Gln His Asp Ile Phe Leu Ser Pro Asn Met Gln Gly
    50                  55                  60                  
Leu Thr Asn Asp Gln Ile Glu Glu Leu Lys Leu Lys Lys Glu Trp Gly
65                  70                  75                  80  
Glu Lys Cys Met His Thr His Thr His His Arg Leu Ser Thr Glu Asp
                85                  90                  95      
His Lys Ser Pro Thr Gln Thr Ser Gly Asn Ser Gln Met Ser Ser His
            100                 105                 110         
Phe Tyr Ile Asn Asp Val Asn Phe Thr Arg Lys Met Leu Leu Met Phe
        115                 120                 125             
Phe Glu Val Ser Ala His Glu Ser Tyr Trp Gly His Ile Asn Ile Met
    130                 135                 140                 
Leu Ile Leu Ala Leu Lys Leu His Asn Pro Lys Ser Pro Pro Lys Ile
145                 150                 155                 160 
Ser Pro Pro Ser Ile Ala Gly Tyr Ser Leu His Glu Lys Ser Cys Trp
                165                 170                 175     
Ser Thr Ile Ala Leu Val Arg Leu Ser Gly Ala Val Ile Asp Gln Gln
            180                 185                 190         
Asp Phe Ser Cys Thr Glu Ser
        195                 


<210> 7749
<211> 317
<212> PRT
<213> Homo sapiens

<400> 7749
Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln
 1               5                  10                  15      
Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly
            20                  25                  30          
Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe
        35                  40                  45              
Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro
    50                  55                  60                  
Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys
65                  70                  75                  80  
Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg
                85                  90                  95      
Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro
            100                 105                 110         
Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro
        115                 120                 125             
Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly
    130                 135                 140                 
Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr
145                 150                 155                 160 
Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp
                165                 170                 175     
Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala
            180                 185                 190         
Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn
        195                 200                 205             
Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser
    210                 215                 220                 
Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met
225                 230                 235                 240 
Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr
                245                 250                 255     
Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp
            260                 265                 270         
Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala
        275                 280                 285             
Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro
    290                 295                 300                 
Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met
305                 310                 315         


<210> 7750
<211> 669
<212> PRT
<213> Homo sapiens

<400> 7750
Met Lys Ile Phe Val Gly Asn Val Asp Gly Ala Asp Thr Thr Pro Glu
 1               5                  10                  15      
Glu Leu Ala Ala Leu Phe Ala Pro Tyr Gly Thr Val Met Ser Cys Ala
            20                  25                  30          
Val Met Lys Gln Phe Ala Phe Val His Met Arg Glu Asn Ala Gly Ala
        35                  40                  45              
Leu Arg Ala Ile Glu Ala Leu His Gly His Glu Leu Arg Pro Gly Arg
    50                  55                  60                  
Ala Leu Val Val Glu Met Ser Arg Pro Arg Pro Leu Asn Thr Trp Lys
65                  70                  75                  80  
Ile Phe Val Gly Asn Val Ser Ala Ala Cys Thr Ser Gln Glu Leu Arg
                85                  90                  95      
Ser Leu Phe Glu Arg Arg Gly Arg Val Ile Glu Cys Asp Val Val Lys
            100                 105                 110         
Asp Tyr Ala Phe Val His Met Glu Lys Glu Ala Asp Ala Lys Ala Ala
        115                 120                 125             
Ile Ala Gln Leu Asn Gly Lys Glu Val Lys Gly Lys Arg Ile Asn Val
    130                 135                 140                 
Glu Leu Ser Thr Lys Gly Gln Lys Lys Gly Pro Gly Leu Ala Val Gln
145                 150                 155                 160 
Ser Gly Asp Lys Thr Lys Lys Pro Gly Ala Gly Asp Thr Ala Phe Pro
                165                 170                 175     
Gly Thr Gly Gly Phe Ser Ala Thr Phe Asp Tyr Gln Gln Ala Phe Gly
            180                 185                 190         
Asn Ser Thr Gly Gly Phe Asp Gly Gln Ala Arg Gln Pro Thr Pro Pro
        195                 200                 205             
Phe Phe Gly Arg Asp Arg Ser Pro Leu Arg Arg Ser Pro Pro Arg Ala
    210                 215                 220                 
Ser Tyr Val Ala Pro Leu Thr Ala Gln Pro Ala Thr Tyr Arg Ala Gln
225                 230                 235                 240 
Pro Ser Val Ser Leu Gly Ala Ala Tyr Arg Ala Gln Pro Ser Ala Ser
                245                 250                 255     
Leu Gly Val Gly Tyr Arg Thr Gln Pro Met Thr Ala Gln Ala Ala Ser
            260                 265                 270         
Tyr Arg Ala Gln Pro Ser Val Ser Leu Gly Ala Pro Tyr Arg Gly Gln
        275                 280                 285             
Leu Ala Ser Pro Ser Ser Gln Ser Ala Ala Ala Ser Ser Leu Gly Pro
    290                 295                 300                 
Tyr Gly Gly Ala Gln Pro Ser Ala Ser Ala Leu Ser Ser Tyr Gly Gly
305                 310                 315                 320 
Gln Ala Ala Ala Ala Ser Ser Leu Asn Ser Tyr Gly Ala Gln Gly Ser
                325                 330                 335     
Ser Leu Ala Ser Tyr Gly Asn Gln Pro Ser Ser Tyr Gly Ala Gln Ala
            340                 345                 350         
Ala Ser Ser Tyr Gly Val Arg Ala Ala Ala Ser Ser Tyr Asn Thr Gln
        355                 360                 365             
Gly Ala Ala Ser Ser Leu Gly Ser Tyr Gly Ala Gln Ala Ala Ser Tyr
    370                 375                 380                 
Gly Ala Gln Ser Ala Ala Ser Ser Leu Ala Tyr Gly Ala Gln Ala Ala
385                 390                 395                 400 
Ser Tyr Asn Ala Gln Pro Ser Ala Ser Tyr Asn Ala Gln Ser Ala Pro
                405                 410                 415     
Tyr Ala Ala Gln Gln Ala Ala Ser Tyr Ser Ser Gln Pro Ala Ala Tyr
            420                 425                 430         
Val Ala Gln Pro Ala Thr Ala Ala Ala Tyr Ala Ser Gln Pro Ala Ala
        435                 440                 445             
Tyr Ala Ala Gln Ala Thr Thr Pro Met Ala Gly Ser Tyr Gly Ala Gln
    450                 455                 460                 
Pro Val Val Gln Thr Gln Leu Asn Ser Tyr Gly Ala Gln Ala Ser Met
465                 470                 475                 480 
Gly Leu Ser Gly Ser Tyr Gly Ala Gln Ser Ala Ala Ala Ala Thr Gly
                485                 490                 495     
Ser Tyr Gly Ala Ala Ala Ala Tyr Gly Ala Gln Pro Ser Ala Thr Leu
            500                 505                 510         
Ala Ala Pro Tyr Arg Thr Gln Ser Ser Ala Ser Leu Ala Ala Ser Tyr
        515                 520                 525             
Ala Ala Gln Gln His Pro Gln Ala Ala Ala Ser Tyr Arg Gly Gln Pro
    530                 535                 540                 
Gly Asn Ala Tyr Asp Gly Ala Gly Gln Pro Ser Ala Ala Tyr Leu Ser
545                 550                 555                 560 
Met Ser Gln Gly Ala Val Ala Asn Ala Asn Ser Thr Pro Pro Pro Tyr
                565                 570                 575     
Glu Arg Thr Arg Leu Ser Pro Pro Arg Ala Ser Tyr Asp Asp Pro Tyr
            580                 585                 590         
Lys Lys Ala Val Ala Met Ser Lys Arg Tyr Gly Ser Asp Arg Arg Leu
        595                 600                 605             
Ala Glu Leu Ser Asp Tyr Arg Arg Leu Ser Glu Ser Gln Leu Ser Phe
    610                 615                 620                 
Arg Arg Ser Pro Thr Lys Ser Ser Leu Asp Tyr Arg Arg Leu Pro Asp
625                 630                 635                 640 
Ala His Ser Asp Tyr Ala Arg Tyr Ser Gly Ser Tyr Asn Asp Tyr Leu
                645                 650                 655     
Arg Ala Ala Gln Met His Ser Gly Tyr Gln Arg Arg Met
            660                 665                 


<210> 7751
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 7751
Met Thr Asp Gln Glu Asn Asn Asn Asn Ile Ser Ser Asn Pro Phe Ala
 1               5                  10                  15      
Ala Leu Phe Gly Ser Leu Ala Asp Ala Lys Gln Phe Ala Ala Ile Gln
            20                  25                  30          
Lys Glu Gln Leu Lys Gln Gln Ser Asp Glu Leu Pro Ala Ser Pro Asp
        35                  40                  45              
Asp Ser Asp Asn Ser Val Ser Glu Ser Leu Asp Glu Phe Asp Tyr Ser
    50                  55                  60                  
Val Ala Glu Ile Ser Arg Ser Phe Arg Ser Gln Gln Glu Ile Cys Glu
65                  70                  75                  80  
Gln Leu Asn Ile Asn His Met Ile Gln Arg Ile Phe Leu Ile Thr Leu
                85                  90                  95      
Asp Asn Ser Asp Pro Ser Leu Lys Ser Gly Asn Gly Ile Pro Ser Arg
            100                 105                 110         
Cys Val Tyr Leu Glu Glu Met Ala Val Glu Leu Glu Asp Gln Asp Trp
        115                 120                 125             
Leu Asp Met Ser Asn Val Glu Gln Ala Leu Phe Ala Arg Leu Leu Leu
    130                 135                 140                 
Gln Asp Pro Gly Asn His Leu Ile Asn Met Thr Ser Ser Thr Thr Leu
145                 150                 155                 160 
Asn Leu Ser Ala Asp Arg Asp Ala Gly Glu Arg His Ile Phe Cys Tyr
                165                 170                 175     
Leu Tyr Ser Cys Phe Gln Arg Ala Lys Glu Glu Ile Thr Lys Val Pro
            180                 185                 190         
Glu Asn Leu Leu Pro Phe Ala Val Gln Cys Arg Asn Leu Thr Val Ser
        195                 200                 205             
Asn Thr Arg Thr Val Leu Leu Thr Leu Glu Ile Tyr Val Asp Gln Asn
    210                 215                 220                 
Ile His Glu Gln Leu Val Asp Leu Met Leu Glu Ala Ile Gln Gly Ala
225                 230                 235                 240 
Arg Glu Tyr Met Asn Lys Ile Tyr Phe Glu Asp Val Thr Glu Phe Leu
                245                 250                 255     
Glu Glu Val Ile Glu Ala Leu Ile Leu Asp Glu Glu Val Arg Thr Phe
            260                 265                 270         
Pro Glu Val Met Ile Pro Val Phe Asp Ile Leu Leu Gly Arg Ile Lys
        275                 280                 285             
Asp Leu Glu Leu Cys Gln Ile Leu Leu Tyr Ala Tyr Leu Asp Ile Leu
    290                 295                 300                 
Leu Tyr Phe Thr Arg Gln Lys Asp Met Ala Lys Val Phe Val Glu Tyr
305                 310                 315                 320 
Ile Gln Pro Lys Asp Pro Thr Asn Gly Gln Met Tyr Gln Lys Thr Leu
                325                 330                 335     
Leu Gly Val Ile Leu Ser Ile Ser Cys Leu Leu Lys Thr Pro Gly Val
            340                 345                 350         
Val Glu Asn His Gly Tyr Phe Leu Asn Pro Ser Arg Ser Ser Pro Gln
        355                 360                 365             
Glu Ile Lys Val Gln Glu Ala Asn Ile His Gln Phe Met Ala Gln Phe
    370                 375                 380                 
His Glu Lys Ile Tyr Gln Met Leu Lys Asn Leu Leu Gln Leu Ser Pro
385                 390                 395                 400 
Glu Thr Lys His Cys Ile Leu Ser Trp Leu Gly Asn Cys Leu His Ala
                405                 410                 415     
Asn Ala Gly Arg Thr Lys Ile Trp Ala Asn Gln Met Pro Glu Ile Phe
            420                 425                 430         
Phe Gln Met Tyr Ala Ser Asp Ala Phe Phe Leu Asn Leu Gly Ala Ala
        435                 440                 445             
Leu Leu Lys Leu Cys Gln Pro Phe Cys Lys Pro Arg Ser Ser Arg Leu
    450                 455                 460                 
Leu Thr Phe Asn Pro Thr Tyr Cys Ala Leu Lys Glu Leu Asn Asp Glu
465                 470                 475                 480 
Glu Arg Lys Ile Lys Asn Val His Met Arg Gly Leu Asp Lys Glu Thr
                485                 490                 495     
Cys Leu Ile Pro Ala Val Gln Glu Pro Lys Phe Pro Gln Asn Tyr Asn
            500                 505                 510         
Leu Val Thr Glu Asn Leu Ala Leu Thr Glu Tyr Thr Leu Tyr Leu Gly
        515                 520                 525             
Phe His Arg Leu His Asp Gln Met Val Lys Ile Asn Gln Asn Leu His
    530                 535                 540                 
Arg Leu Gln Val Ala Trp Arg Asp Ala Gln Gln Ser Ser Ser Pro Ala
545                 550                 555                 560 
Ala Asp Asn Leu Arg Glu Gln Phe Glu Arg Leu Met Thr Ile Tyr Leu
                565                 570                 575     
Ser Thr Lys Thr Ala Met Thr Glu Pro Gln Met Leu Gln Asn Cys Leu
            580                 585                 590         
Asn Leu Gln Val Ser Met Ala Val Leu Leu Val Gln Leu Ala Ile Gly
        595                 600                 605             
Asn Glu Gly Ser Gln Pro Ile Glu Leu Thr Phe Pro Leu Pro Asp Gly
    610                 615                 620                 
Tyr Ser Ser Leu Ala Tyr Val Pro Glu Phe Phe Ala Asp Asn Leu Gly
625                 630                 635                 640 
Asp Phe Leu Ile Phe Leu Arg Arg Phe Ala Asp Asp Ile Leu Glu Thr
                645                 650                 655     
Ser Ala Asp Ser Leu Glu His Val Leu His Phe Ile Thr Ile Phe Thr
            660                 665                 670         
Gly Ser Ile Glu Arg Met Lys Asn Pro His Leu Arg Ala Lys Leu Ala
        675                 680                 685             
Glu Val Leu Glu Ala Val Met Pro His Leu Asp Gln Thr Pro Asn Pro
    690                 695                 700                 
Leu Val Ser Ser Val Phe His Arg Lys Arg Val Phe Cys Asn Phe Gln
705                 710                 715                 720 
Tyr Ala Pro Gln Leu Ala Glu Ala Leu Ile Lys Val Phe Val Asp Ile
                725                 730                 735     
Glu Phe Thr Gly Asp Pro His Gln Phe Glu Gln Lys Phe Asn Tyr Arg
            740                 745                 750         
Arg Pro Met Tyr Pro Ile Leu Arg Tyr Met Trp Gly Thr Asp Thr Tyr
        755                 760                 765             
Arg Glu Ser Ile Lys Asp Leu Ala Asp Tyr Ala Ser Lys Asn Leu Glu
    770                 775                 780                 
Ala Met Asn Pro Pro Leu Phe Leu Arg Phe Leu Asn Leu Leu Met Asn
785                 790                 795                 800 
Asp Ala Ile Phe Leu Leu Asp Glu Ala Ile Gln Tyr Leu Ser Lys Ile
                805                 810                 815     
Lys Ile Gln Gln Ile Glu Lys Asp Arg Gly Glu Trp Asp Ser Leu Thr
            820                 825                 830         
Pro Glu Ala Arg Arg Glu Lys Glu Ala Gly Leu Gln Met Phe Gly Gln
        835                 840                 845             
Leu Ala Arg Phe His Asn Ile Met Ser Asn Glu Thr Ile Gly Thr Leu
    850                 855                 860                 
Ala Phe Leu Thr Ser Glu Ile Lys Ser Leu Phe Val His Pro Phe Leu
865                 870                 875                 880 
Ala Glu Arg Ile Ile Ser Met Leu Asn Tyr Phe Leu Gln His Leu Val
                885                 890                 895     
Gly Pro Lys Met Gly Ala Leu Lys Val Lys Asp Phe Ser Glu Phe Asp
            900                 905                 910         
Phe Lys Pro Gln Gln Leu Val Ser Asp Ile Cys Thr Ile Tyr Leu Asn
        915                 920                 925             
Leu Gly Asp Glu Glu Asn Phe Cys Ala Thr Val Pro Lys Asp Gly Arg
    930                 935                 940                 
Ser Tyr Ser Pro Thr Leu Phe Ala Gln Thr Val Arg Val Leu Lys Lys
945                 950                 955                 960 
Ile Asn Lys Pro Gly Asn Met Ile Met Ala Phe Ser Asn Leu Ala Glu
                965                 970                 975     
Arg Ile Lys Ser Leu Ala Asp Leu Gln Gln Gln Glu Glu Glu Thr Tyr
            980                 985                 990         
Ala Asp Ala Cys Asp Glu Phe Leu Asp Pro Ile Met Ser Thr Leu Met
        995                 1000                1005            
Cys Asp Pro Val Val Leu Pro Ser Ser Arg Val Thr Val Asp Arg Ser
    1010                1015                1020                
Thr Ile Ala Arg His Leu Leu Ser Asp Gln Thr Asp Pro Phe Asn Arg
1025                1030                1035                1040
Ser Pro Leu Thr Met Asp Gln Ile Arg Pro Asn Thr Glu Leu Lys Glu
                1045                1050                1055    
Lys Ile Gln Arg Trp Leu Ala Glu Arg Lys Gln Gln Lys Glu Gln Leu
            1060                1065                1070        
Glu
    


<210> 7752
<211> 2868
<212> PRT
<213> Homo sapiens

<400> 7752
Met Gln Lys Ser Leu Thr Asp Leu Glu Ile Gln Leu Ser Arg Ile Thr
 1               5                  10                  15      
Glu Tyr Gly Tyr Asp Gly Phe Leu Lys Trp Leu Asn Cys Leu Phe His
            20                  25                  30          
Ser Asn Ile Thr Ser Asp Leu Lys Ala Phe Thr Asp Lys Phe Gly Phe
        35                  40                  45              
Asp Val Leu Ile Leu Phe Ser Ser Tyr Leu Ser Glu Glu Gln Gln Pro
    50                  55                  60                  
Arg Arg Gln Ile Ala Val Tyr Ser Glu Asn Met Glu Leu Cys Ser Gln
65                  70                  75                  80  
Ile Cys Cys Glu Leu Glu Glu Cys Gln Asn Pro Cys Leu Glu Leu Glu
                85                  90                  95      
Pro Phe Asp Cys Gly Cys Asp Glu Ile Leu Val Tyr Gln Gln Glu Asp
            100                 105                 110         
Pro Ser Val Thr Cys Asp Gln Val Val Leu Val Val Lys Glu Val Ile
        115                 120                 125             
Asn Arg Arg Cys Pro Glu Met Val Ser Asn Ser Arg Thr Ser Ser Thr
    130                 135                 140                 
Glu Ala Val Ala Gly Ser Ala Pro Leu Ser Gln Gly Ser Ser Gly Ile
145                 150                 155                 160 
Met Glu Leu Tyr Gly Ser Asp Ile Glu Pro Gln Pro Ser Ser Val Asn
                165                 170                 175     
Phe Ile Glu Asn Pro Pro Asp Leu Asn Asp Ser Asn Gln Ala Gln Val
            180                 185                 190         
Asp Ala Asn Val Asp Leu Val Ser Pro Asp Ser Gly Leu Ala Thr Ile
        195                 200                 205             
Arg Ser Ser Arg Ser Ser Lys Glu Ser Ser Val Phe Leu Ser Asp Asp
    210                 215                 220                 
Ser Pro Val Gly Glu Gly Ala Gly Pro His His Thr Leu Leu Pro Gly
225                 230                 235                 240 
Leu Asp Ser Tyr Ser Pro Ile Pro Glu Gly Ala Val Ala Glu Glu His
                245                 250                 255     
Ala Trp Ser Gly Glu His Gly Glu His Phe Asp Leu Phe Asn Phe Asp
            260                 265                 270         
Pro Ala Pro Met Ala Ser Gly Gln Ser Gln Gln Ser Ser His Ser Ala
        275                 280                 285             
Asp Tyr Ser Pro Ala Asp Asp Phe Phe Pro Asn Ser Asp Leu Ser Glu
    290                 295                 300                 
Gly Gln Leu Pro Ala Gly Pro Glu Gly Leu Asp Gly Met Gly Thr Asn
305                 310                 315                 320 
Met Ser Asn Tyr Ser Ser Ser Ser Leu Leu Ser Gly Ala Gly Lys Asp
                325                 330                 335     
Ser Leu Val Glu His Asp Glu Glu Phe Val Gln Arg Gln Asp Ser Pro
            340                 345                 350         
Arg Asp Asn Ser Glu Arg Asn Leu Ser Leu Thr Asp Phe Val Gly Asp
        355                 360                 365             
Glu Ser Pro Ser Pro Glu Arg Leu Lys Asn Thr Gly Lys Arg Ile Pro
    370                 375                 380                 
Pro Thr Pro Met Asn Ser Leu Val Glu Ser Ser Pro Ser Thr Glu Glu
385                 390                 395                 400 
Pro Ala Ser Leu Tyr Thr Glu Asp Met Thr Gln Lys Ala Thr Asp Thr
                405                 410                 415     
Gly His Met Gly Pro Pro Gln Thr His Ala Arg Cys Ser Ser Trp Trp
            420                 425                 430         
Gly Gly Leu Glu Ile Asp Ser Lys Asn Ile Ala Asp Ala Trp Ser Ser
        435                 440                 445             
Ser Glu Gln Glu Ser Val Phe Gln Ser Pro Glu Ser Trp Lys Glu His
    450                 455                 460                 
Lys Pro Ser Ser Ile Asp Arg Arg Ala Ser Asp Ser Val Phe Gln Pro
465                 470                 475                 480 
Lys Ser Leu Glu Phe Thr Lys Ser Gly Pro Trp Glu Ser Glu Phe Gly
                485                 490                 495     
Gln Pro Glu Leu Gly Ser Asn Asp Ile Gln Asp Lys Asn Glu Glu Ser
            500                 505                 510         
Leu Pro Phe Gln Asn Leu Pro Met Glu Lys Ser Pro Leu Pro Asn Thr
        515                 520                 525             
Ser Pro Gln Gly Thr Asn His Leu Ile Glu Asp Phe Ala Ser Leu Trp
    530                 535                 540                 
His Ser Gly Arg Ser Pro Thr Ala Met Pro Glu Pro Trp Gly Asn Pro
545                 550                 555                 560 
Thr Asp Asp Gly Glu Pro Ala Ala Val Ala Pro Phe Pro Ala Trp Ser
                565                 570                 575     
Ala Phe Gly Lys Glu Asp His Asp Glu Ala Leu Lys Asn Thr Trp Asn
            580                 585                 590         
Leu His Pro Thr Ser Ser Lys Thr Pro Ser Val Arg Asp Pro Asn Glu
        595                 600                 605             
Trp Ala Met Ala Lys Ser Gly Phe Ala Phe Ser Ser Ser Glu Leu Leu
    610                 615                 620                 
Asp Asn Ser Pro Ser Glu Ile Asn Asn Glu Ala Ala Pro Glu Ile Trp
625                 630                 635                 640 
Gly Lys Lys Asn Asn Asp Ser Arg Asp His Ile Phe Ala Pro Gly Asn
                645                 650                 655     
Pro Ser Ser Asp Leu Asp His Thr Trp Thr Asn Ser Lys Pro Pro Lys
            660                 665                 670         
Glu Asp Gln Asn Gly Leu Val Asp Pro Lys Thr Arg Gly Lys Val Tyr
        675                 680                 685             
Glu Lys Val Asp Ser Trp Asn Leu Phe Glu Glu Asn Met Lys Lys Gly
    690                 695                 700                 
Gly Ser Asp Val Leu Val Pro Trp Glu Asp Ser Phe Leu Ser Tyr Lys
705                 710                 715                 720 
Cys Ser Asp Tyr Ser Ala Ser Asn Leu Gly Glu Asp Ser Val Pro Ser
                725                 730                 735     
Pro Leu Asp Thr Asn Tyr Ser Thr Ser Asp Ser Tyr Thr Ser Pro Thr
            740                 745                 750         
Phe Ala Gly Asp Glu Lys Glu Thr Glu His Lys Pro Phe Ala Lys Glu
        755                 760                 765             
Glu Gly Phe Glu Ser Lys Asp Gly Asn Ser Thr Ala Glu Glu Thr Asp
    770                 775                 780                 
Ile Pro Pro Gln Ser Leu Gln Gln Ser Ser Arg Asn Arg Ile Ser Ser
785                 790                 795                 800 
Gly Pro Gly Asn Leu Asp Met Trp Ala Ser Pro His Thr Asp Asn Ser
                805                 810                 815     
Ser Glu Ile Asn Thr Thr His Asn Leu Asp Glu Asn Glu Leu Lys Thr
            820                 825                 830         
Glu His Thr Asp Gly Lys Asn Ile Ser Met Glu Asp Asp Val Gly Glu
        835                 840                 845             
Ser Ser Gln Ser Ser Tyr Asp Asp Pro Ser Met Met Gln Leu Tyr Asn
    850                 855                 860                 
Glu Thr Asn Arg Gln Leu Thr Leu Leu His Ser Ser Thr Asn Ser Arg
865                 870                 875                 880 
Gln Thr Ala Pro Asp Ser Leu Asp Leu Trp Asn Arg Val Ile Leu Glu
                885                 890                 895     
Asp Thr Gln Ser Thr Ala Thr Ile Ser Asp Met Asp Asn Asp Leu Asp
            900                 905                 910         
Trp Asp Asp Cys Ser Gly Gly Ala Ala Ile Pro Ser Asp Gly Gln Thr
        915                 920                 925             
Glu Gly Tyr Met Ala Glu Gly Ser Glu Pro Glu Thr Arg Phe Thr Val
    930                 935                 940                 
Arg Gln Leu Glu Pro Trp Gly Leu Glu Tyr Gln Glu Ala Asn Gln Val
945                 950                 955                 960 
Asp Trp Glu Leu Pro Ala Ser Asp Glu His Thr Lys Asp Ser Ala Pro
                965                 970                 975     
Ser Glu His His Thr Leu Asn Glu Lys Ser Gly Gln Leu Ile Ala Asn
            980                 985                 990         
Ser Ile Trp Asp Ser Val Met Arg Asp Lys Asp Met Ser Ser Phe Met
        995                 1000                1005            
Leu Pro Gly Ser Ser His Ile Thr Asp Ser Glu Gln Arg Glu Leu Pro
    1010                1015                1020                
Pro Glu Ile Pro Ser His Ser Ala Asn Val Lys Asp Thr His Ser Pro
1025                1030                1035                1040
Asp Ala Pro Ala Ala Ser Gly Thr Ser Glu Ser Glu Ala Leu Ile Ser
                1045                1050                1055    
His Leu Asp Lys Gln Asp Thr Glu Arg Glu Thr Leu Gln Ser Asp Ala
            1060                1065                1070        
Ala Ser Leu Ala Thr Arg Leu Glu Asn Pro Gly Tyr Phe Pro His Pro
        1075                1080                1085            
Asp Pro Trp Lys Gly His Gly Asp Gly Gln Ser Glu Ser Glu Lys Glu
    1090                1095                1100                
Ala Gln Gly Ala Thr Asp Arg Gly His Leu Asp Glu Glu Glu Val Ile
1105                1110                1115                1120
Ala Ser Gly Val Glu Asn Ala Ser Gly Ile Ser Glu Lys Gly Gln Ser
                1125                1130                1135    
Asp Gln Glu Leu Ser Ser Leu Val Ala Ser Glu His Gln Glu Ile Cys
            1140                1145                1150        
Ile Lys Ser Gly Lys Ile Ser Ser Leu Ala Val Thr Phe Ser Pro Gln
        1155                1160                1165            
Thr Glu Glu Pro Glu Glu Val Leu Glu Tyr Glu Glu Gly Ser Tyr Asn
    1170                1175                1180                
Leu Asp Ser Arg Asp Val Gln Thr Gly Met Ser Ala Asp Asn Leu Gln
1185                1190                1195                1200
Pro Lys Asp Thr His Glu Lys His Leu Met Ser Gln Arg Asn Ser Gly
                1205                1210                1215    
Glu Thr Thr Glu Thr Ser Asp Gly Met Asn Phe Thr Lys Tyr Val Ser
            1220                1225                1230        
Val Pro Glu Lys Asp Leu Glu Lys Thr Glu Glu Cys Asn Phe Leu Glu
        1235                1240                1245            
Pro Glu Asn Val Gly Gly Gly Pro Pro His Arg Val Pro Arg Ser Leu
    1250                1255                1260                
Asp Phe Gly Asp Val Pro Ile Asp Ser Asp Val His Val Ser Ser Thr
1265                1270                1275                1280
Cys Ser Glu Ile Thr Lys Asn Leu Asp Val Lys Gly Ser Glu Asn Ser
                1285                1290                1295    
Leu Pro Gly Ala Gly Ser Ser Gly Asn Phe Asp Arg Asp Thr Ile Ser
            1300                1305                1310        
Ser Glu Tyr Thr His Ser Ser Ala Ser Ser Pro Glu Leu Asn Asp Ser
        1315                1320                1325            
Ser Val Ala Leu Ser Ser Trp Gly Gln Gln Pro Ser Ser Gly Tyr Gln
    1330                1335                1340                
Glu Glu Asn Gln Gly Asn Trp Ser Glu Gln Asn His Gln Glu Ser Glu
1345                1350                1355                1360
Leu Ile Thr Thr Asp Gly Gln Val Glu Ile Val Thr Lys Val Lys Asp
                1365                1370                1375    
Leu Glu Lys Asn Arg Ile Asn Glu Phe Glu Lys Ser Phe Asp Arg Lys
            1380                1385                1390        
Thr Pro Thr Phe Leu Glu Ile Trp Asn Asp Ser Val Asp Gly Asp Ser
        1395                1400                1405            
Phe Ser Ser Leu Ser Ser Pro Glu Thr Gly Lys Tyr Ser Glu His Ser
    1410                1415                1420                
Gly Thr His Gln Glu Ser Asn Leu Ile Ala Ser Tyr Gln Glu Lys Asn
1425                1430                1435                1440
Glu His Asp Ile Ser Ala Thr Val Gln Pro Glu Asp Ala Arg Val Ile
                1445                1450                1455    
Ser Thr Ser Ser Gly Ser Asp Asp Asp Ser Val Gly Gly Glu Glu Ser
            1460                1465                1470        
Ile Glu Glu Glu Ile Gln Val Ala Asn Cys His Val Ala Glu Asp Glu
        1475                1480                1485            
Ser Arg Ala Trp Asp Ser Leu Asn Glu Ser Asn Lys Phe Leu Val Thr
    1490                1495                1500                
Ala Asp Pro Lys Ser Glu Asn Ile Tyr Asp Tyr Leu Asp Ser Ser Glu
1505                1510                1515                1520
Pro Ala Glu Asn Glu Asn Lys Ser Asn Pro Phe Cys Asp Asn Gln Gln
                1525                1530                1535    
Ser Ser Pro Asp Pro Trp Thr Phe Ser Pro Leu Thr Glu Thr Glu Met
            1540                1545                1550        
Gln Ile Thr Ala Val Glu Lys Glu Lys Arg Ser Ser Pro Glu Thr Gly
        1555                1560                1565            
Thr Thr Gly Asp Val Ala Trp Gln Ile Ser Pro Lys Ala Ser Phe Pro
    1570                1575                1580                
Lys Asn Glu Asp Asn Ser Gln Leu Glu Met Leu Gly Phe Ser Ala Asp
1585                1590                1595                1600
Ser Thr Glu Trp Trp Lys Ala Ser Pro Gln Glu Gly Arg Leu Ile Glu
                1605                1610                1615    
Ser Pro Phe Glu Arg Glu Leu Ser Asp Ser Ser Gly Val Leu Glu Ile
            1620                1625                1630        
Asn Ser Ser Val His Gln Asn Ala Ser Pro Trp Gly Val Pro Val Gln
        1635                1640                1645            
Gly Asp Ile Glu Pro Val Glu Thr His Tyr Thr Asn Pro Phe Ser Asp
    1650                1655                1660                
Asn His Gln Ser Pro Phe Leu Glu Gly Asn Gly Lys Asn Ser His Glu
1665                1670                1675                1680
Gln Leu Trp Asn Ile Gln Pro Arg Gln Pro Asp Pro Asp Ala Asp Lys
                1685                1690                1695    
Phe Ser Gln Leu Val Lys Leu Asp Gln Ile Lys Glu Lys Asp Ser Arg
            1700                1705                1710        
Glu Gln Thr Phe Val Ser Ala Ala Gly Asp Glu Leu Thr Pro Glu Thr
        1715                1720                1725            
Pro Thr Gln Glu Gln Cys Gln Asp Thr Met Leu Pro Val Cys Asp His
    1730                1735                1740                
Pro Asp Thr Ala Phe Thr His Ala Glu Glu Asn Ser Cys Val Thr Ser
1745                1750                1755                1760
Asn Val Ser Thr Asn Glu Gly Gln Glu Thr Asn Gln Trp Glu Gln Glu
                1765                1770                1775    
Lys Ser Tyr Leu Gly Glu Met Thr Asn Ser Ser Ile Ala Thr Glu Asn
            1780                1785                1790        
Phe Pro Ala Val Ser Ser Pro Thr Gln Leu Ile Met Lys Pro Gly Ser
        1795                1800                1805            
Glu Trp Asp Gly Ser Thr Pro Ser Glu Asp Ser Arg Gly Thr Phe Val
    1810                1815                1820                
Pro Asp Ile Leu His Gly Asn Phe Gln Glu Gly Gly Gln Leu Ala Ser
1825                1830                1835                1840
Ala Ala Pro Asp Leu Trp Ile Asp Ala Lys Lys Pro Phe Ser Leu Lys
                1845                1850                1855    
Ala Asp Gly Glu Asn Pro Asp Ile Leu Thr His Cys Glu His Asp Ser
            1860                1865                1870        
Asn Ser Gln Ala Ser Asp Ser Pro Asp Ile Cys His Asp Ser Glu Ala
        1875                1880                1885            
Lys Gln Glu Thr Glu Lys His Leu Ser Ala Cys Met Gly Pro Glu Val
    1890                1895                1900                
Glu Ser Ser Glu Leu Cys Leu Thr Glu Pro Glu Ile Asp Glu Glu Pro
1905                1910                1915                1920
Ile Tyr Glu Pro Gly Arg Glu Phe Val Pro Ser Asn Ala Glu Leu Asp
                1925                1930                1935    
Ser Glu Asn Ala Thr Val Leu Pro Pro Ile Gly Tyr Gln Ala Asp Ile
            1940                1945                1950        
Lys Gly Ser Ser Gln Pro Ala Ser His Lys Gly Ser Pro Glu Pro Ser
        1955                1960                1965            
Glu Ile Asn Gly Asp Asn Ser Thr Gly Leu Gln Val Ser Glu Lys Gly
    1970                1975                1980                
Ala Ser Pro Asp Met Ala Pro Ile Leu Glu Pro Val Asp Arg Arg Ile
1985                1990                1995                2000
Pro Arg Ile Glu Asn Val Ala Thr Ser Ile Phe Val Thr His Gln Glu
                2005                2010                2015    
Pro Thr Pro Glu Gly Asp Gly Ser Trp Ile Ser Asp Ser Phe Ser Pro
            2020                2025                2030        
Glu Ser Gln Pro Gly Ala Arg Ala Leu Phe Asp Gly Asp Pro His Leu
        2035                2040                2045            
Ser Thr Glu Asn Pro Ala Leu Val Pro Asp Ala Leu Leu Ala Ser Asp
    2050                2055                2060                
Thr Cys Leu Asp Ile Ser Glu Ala Ala Phe Asp His Ser Phe Ser Asp
2065                2070                2075                2080
Ala Ser Gly Leu Asn Thr Ser Thr Gly Thr Ile Asp Asp Met Ser Lys
                2085                2090                2095    
Leu Thr Leu Ser Glu Gly His Pro Glu Thr Pro Val Asp Gly Asp Leu
            2100                2105                2110        
Gly Lys Gln Asp Ile Cys Ser Ser Glu Ala Ser Trp Gly Asp Phe Glu
        2115                2120                2125            
Tyr Asp Val Met Gly Gln Asn Ile Asp Glu Asp Leu Leu Arg Glu Pro
    2130                2135                2140                
Glu His Phe Leu Tyr Gly Gly Asp Pro Pro Leu Glu Glu Asp Ser Leu
2145                2150                2155                2160
Lys Gln Ser Leu Ala Pro Tyr Thr Pro Pro Phe Asp Leu Ser Tyr Leu
                2165                2170                2175    
Thr Glu Pro Ala Gln Ser Ala Glu Thr Ile Glu Glu Ala Gly Ser Pro
            2180                2185                2190        
Glu Asp Glu Ser Leu Gly Cys Arg Ala Ala Glu Ile Val Leu Ser Ala
        2195                2200                2205            
Leu Pro Asp Arg Arg Ser Glu Gly Asn Gln Ala Glu Thr Lys Asn Arg
    2210                2215                2220                
Leu Pro Gly Ser Gln Leu Ala Val Leu His Ile Arg Glu Asp Pro Glu
2225                2230                2235                2240
Ser Val Tyr Leu Pro Val Gly Ala Gly Ser Asn Ile Leu Ser Pro Ser
                2245                2250                2255    
Asn Val Asp Trp Glu Val Glu Thr Asp Asn Ser Asp Leu Pro Ala Gly
            2260                2265                2270        
Gly Asp Ile Gly Pro Pro Asn Gly Ala Ser Lys Glu Ile Ser Glu Leu
        2275                2280                2285            
Glu Glu Glu Lys Thr Ile Pro Thr Lys Glu Pro Glu Gln Ile Lys Ser
    2290                2295                2300                
Glu Tyr Lys Glu Glu Arg Cys Thr Glu Lys Asn Glu Asp Arg His Ala
2305                2310                2315                2320
Leu His Met Asp Tyr Ile Leu Val Asn Arg Glu Glu Asn Ser His Ser
                2325                2330                2335    
Lys Pro Glu Thr Cys Glu Glu Arg Glu Ser Ile Ala Glu Leu Glu Leu
            2340                2345                2350        
Tyr Val Gly Ser Lys Glu Thr Gly Leu Gln Gly Thr Gln Leu Ala Ser
        2355                2360                2365            
Phe Pro Asp Thr Cys Gln Pro Ala Ser Leu Asn Glu Arg Lys Gly Leu
    2370                2375                2380                
Ser Ala Glu Lys Met Ser Ser Lys Ser Asp Thr Arg Ser Ser Phe Glu
2385                2390                2395                2400
Ser Pro Ala Gln Asp Gln Ser Trp Met Phe Leu Gly His Ser Glu Val
                2405                2410                2415    
Gly Asp Pro Ser Leu Asp Ala Arg Asp Ser Gly Pro Gly Trp Ser Gly
            2420                2425                2430        
Lys Thr Val Glu Pro Phe Ser Glu Leu Gly Leu Gly Glu Gly Pro Gln
        2435                2440                2445            
Leu Gln Ile Leu Glu Glu Met Lys Pro Leu Glu Ser Leu Ala Leu Glu
    2450                2455                2460                
Glu Ala Ser Gly Pro Val Ser Gln Ser Gln Lys Ser Lys Ser Arg Gly
2465                2470                2475                2480
Arg Ala Gly Pro Asp Ala Val Thr Leu Gln Ala Val Thr His Asp Asn
                2485                2490                2495    
Glu Trp Glu Met Leu Ser Pro Gln Pro Val Gln Lys Asn Met Ile Pro
            2500                2505                2510        
Asp Thr Glu Met Glu Glu Glu Thr Glu Phe Leu Glu Leu Gly Thr Arg
        2515                2520                2525            
Ile Ser Arg Pro Asn Gly Leu Leu Ser Glu Asp Val Gly Met Asp Ile
    2530                2535                2540                
Pro Phe Glu Glu Gly Val Leu Ser Pro Ser Ala Ala Asp Met Arg Pro
2545                2550                2555                2560
Glu Pro Pro Asn Ser Leu Asp Leu Asn Asp Thr His Pro Arg Arg Ile
                2565                2570                2575    
Lys Leu Thr Ala Pro Asn Ile Asn Leu Ser Leu Asp Gln Ser Glu Gly
            2580                2585                2590        
Ser Ile Leu Ser Asp Asp Asn Leu Asp Ser Pro Asp Glu Ile Asp Ile
        2595                2600                2605            
Asn Val Asp Glu Leu Asp Thr Pro Asp Glu Ala Asp Ser Phe Glu Tyr
    2610                2615                2620                
Thr Gly His Glu Asp Pro Thr Ala Asn Lys Asp Ser Gly Gln Glu Ser
2625                2630                2635                2640
Glu Ser Ile Pro Glu Tyr Thr Ala Glu Glu Glu Arg Glu Asp Asn Arg
                2645                2650                2655    
Leu Trp Arg Thr Val Val Ile Gly Glu Gln Glu Gln Arg Ile Asp Met
            2660                2665                2670        
Lys Val Ile Glu Pro Tyr Arg Arg Val Ile Ser His Gly Gly Ser Arg
        2675                2680                2685            
Ala Arg Tyr Tyr Gly Asp Gly Leu Asn Ala Ile Ile Val Phe Ala Ala
    2690                2695                2700                
Cys Phe Leu Pro Asp Ser Ser Arg Ala Asp Tyr His Tyr Val Met Glu
2705                2710                2715                2720
Asn Leu Phe Leu Tyr Val Ile Ser Thr Leu Glu Leu Met Val Ala Glu
                2725                2730                2735    
Asp Tyr Met Ile Val Tyr Leu Asn Gly Ala Thr Pro Arg Arg Arg Met
            2740                2745                2750        
Pro Gly Leu Gly Trp Met Lys Lys Cys Tyr Gln Met Ile Asp Arg Arg
        2755                2760                2765            
Leu Arg Lys Asn Leu Lys Ser Phe Ile Ile Val His Pro Ser Trp Phe
    2770                2775                2780                
Ile Arg Thr Ile Leu Ala Val Thr Arg Pro Phe Ile Ser Ser Lys Phe
2785                2790                2795                2800
Ser Ser Lys Ile Lys Tyr Val Asn Ser Leu Ser Glu Leu Ser Gly Leu
                2805                2810                2815    
Ile Pro Met Asp Cys Ile His Ile Pro Glu Ser Ile Ile Lys Leu Asp
            2820                2825                2830        
Glu Glu Leu Arg Glu Ala Ser Glu Ala Ala Lys Thr Ser Cys Leu Tyr
        2835                2840                2845            
Asn Asp Pro Glu Met Ser Ser Met Glu Lys Asp Ile Asp Leu Lys Leu
    2850                2855                2860                
Lys Glu Lys Pro
2865            


<210> 7753
<211> 1007
<212> PRT
<213> Homo sapiens

<400> 7753
Met Ser His Phe Pro Asp Arg Gly Ser Glu Asn Gly Thr Pro Met Asp
 1               5                  10                  15      
Val Lys Ala Gly Val Arg Val Met Gln Val Ser Pro Asp Gly Gln His
            20                  25                  30          
Leu Ala Ser Gly Asp Arg Ser Gly Asn Leu Arg Gln Val Gly Pro Gly
        35                  40                  45              
Ser Val Gln Cys Thr Pro Pro Ser Ser Ser Ser Gly Ser Gln Gly Ser
    50                  55                  60                  
Gly Gln Lys Pro Trp Pro Trp His Leu Leu Leu Pro Ile Gly Asn Glu
65                  70                  75                  80  
Gly Leu Ile His Glu Leu His Phe Met Asp Glu Leu Val Lys Val Glu
                85                  90                  95      
Ala His Asp Ala Glu Val Leu Cys Leu Glu Tyr Ser Lys Pro Glu Thr
            100                 105                 110         
Gly Leu Thr Leu Leu Ala Ser Ala Ser Arg Asp Arg Leu Ile His Val
        115                 120                 125             
Leu Asn Val Glu Lys Asn Tyr Asn Leu Glu Gln Thr Leu Asp Asp His
    130                 135                 140                 
Ser Ser Ser Ile Thr Ala Ile Lys Phe Ala Gly Asn Arg Asp Ile Gln
145                 150                 155                 160 
Met Ile Ser Cys Gly Ala Asp Lys Ser Ile Tyr Phe Arg Ser Ala Gln
                165                 170                 175     
Gln Gly Ser Asp Gly Leu His Phe Val Arg Thr His His Val Ala Glu
            180                 185                 190         
Lys Thr Thr Leu Tyr Asp Met Asp Ile Asp Ile Thr Gln Lys Tyr Val
        195                 200                 205             
Ala Val Ala Cys Gln Asp Arg Asn Val Arg Val Tyr Asn Thr Val Asn
    210                 215                 220                 
Gly Lys Gln Lys Lys Cys Tyr Lys Gly Ser Gln Gly Asp Glu Gly Ser
225                 230                 235                 240 
Leu Leu Lys Val His Val Asp Pro Ser Gly Thr Phe Leu Ala Thr Ser
                245                 250                 255     
Cys Ser Asp Lys Ser Ile Ser Val Ile Asp Phe Tyr Ser Gly Glu Cys
            260                 265                 270         
Ile Ala Lys Met Phe Gly His Ser Gly Gly Cys Ala Ser Leu Leu Gly
        275                 280                 285             
Met Pro Pro His Pro Pro Thr Pro Ser Asp Ser Glu Gly Lys Cys Ser
    290                 295                 300                 
Leu Ser Ala Leu Phe Ala Glu Ile Ile Thr Ser Met Lys Phe Thr Tyr
305                 310                 315                 320 
Asp Cys His His Leu Ile Thr Val Ser Gly Asp Ser Cys Val Phe Ile
                325                 330                 335     
Trp His Leu Gly Pro Glu Ile Thr Asn Cys Met Lys Gln His Leu Leu
            340                 345                 350         
Glu Ile Asp His Arg Gln Gln Gln Gln His Thr Asn Asp Lys Lys Arg
        355                 360                 365             
Ser Gly His Pro Arg Ser Trp Gln Pro Leu Pro Val His Gln Arg Asp
    370                 375                 380                 
Glu Ser Leu Pro Gly Pro His Gly Val Met Leu Gly Thr Gln Ser Ser
385                 390                 395                 400 
Leu Pro Ala Asn Gln Arg Gln Ala Ala Thr Val Gly Lys Ala Ala Gly
                405                 410                 415     
Asp Asp Asp Val Ala Asp Gly Leu Ala Phe His Ala Lys Arg Ser Tyr
            420                 425                 430         
Gln Pro His Gly Arg Trp Ala Glu Arg Ala Gly Gln Glu Pro Leu Lys
        435                 440                 445             
Thr Ile Leu Asp Ala Gln Asp Leu Asp Cys Tyr Phe Thr Pro Met Lys
    450                 455                 460                 
Pro Glu Ser Leu Glu Asn Ser Ile Leu Asp Ser Leu Glu Pro Gln Ser
465                 470                 475                 480 
Leu Ala Ser Leu Leu Ser Glu Gln Lys Glu Ser Ser Glu Ala Ser Glu
                485                 490                 495     
Leu Ile Leu Tyr Ser Leu Glu Ala Glu Val Thr Val Thr Gly Thr Asp
            500                 505                 510         
Ser Gln Tyr Cys Arg Lys Glu Val Glu Ala Gly Pro Gly Asp Gln Gln
        515                 520                 525             
Gly Asp Ser Tyr Leu Arg Val Ser Ser Asp Ser Pro Lys Asp Gln Ser
    530                 535                 540                 
Pro Pro Glu Gly Pro Thr Glu Asp Glu Leu Ser Leu Pro Glu Gly Pro
545                 550                 555                 560 
Ser Val Pro Ser Ser Ser Leu Pro Gln Thr Pro Glu Gln Glu Lys Phe
                565                 570                 575     
Leu Arg His His Phe Glu Thr Leu Thr Glu Ser Pro Cys Arg Ala Leu
            580                 585                 590         
Gly Asp Val Glu Ala Ser Glu Ala Glu Asp His Phe Phe Asn Pro Arg
        595                 600                 605             
Leu Ser Ile Ser Thr Gln Phe Leu Ser Ser Leu Gln Lys Ala Ser Arg
    610                 615                 620                 
Phe Thr His Thr Phe Pro Pro Arg Ala Thr Gln Cys Leu Val Lys Ser
625                 630                 635                 640 
Pro Glu Val Lys Leu Met Asp Arg Gly Gly Ser Gln Pro Arg Ala Gly
                645                 650                 655     
Thr Gly Tyr Ala Ser Pro Asp Arg Thr His Ser Val Pro Ser Ala Ser
            660                 665                 670         
Val Thr Ala Pro Cys Leu Thr Ser Leu Ala Ser Cys Val Pro Ala Ser
        675                 680                 685             
Ser Val Leu Pro Thr Asp Arg Asn Leu Pro Thr Pro Thr Ser Ala Pro
    690                 695                 700                 
Thr Pro Gly Leu Ala Gln Gly Val His Ala Pro Ser Thr Cys Ser Tyr
705                 710                 715                 720 
Met Glu Ala Thr Ala Ser Ser Arg Ala Arg Ile Ser Arg Ser Ile Ser
                725                 730                 735     
Leu Gly Asp Ser Glu Gly Pro Ile Val Ala Thr Leu Ala Gln Pro Leu
            740                 745                 750         
Arg Arg Pro Ser Ser Val Gly Glu Leu Ala Ser Leu Gly Gln Glu Leu
        755                 760                 765             
Gln Ala Ile Thr Thr Ala Thr Thr Pro Ser Leu Asp Ser Glu Gly Gln
    770                 775                 780                 
Glu Pro Ala Leu Arg Ser Trp Gly Asn His Glu Ala Arg Ala Asn Leu
785                 790                 795                 800 
Arg Leu Thr Leu Ser Ser Ala Cys Asp Gly Leu Leu Gln Pro Pro Val
                805                 810                 815     
Asp Thr Gln Pro Gly Val Thr Val Pro Ala Val Ser Phe Pro Ala Pro
            820                 825                 830         
Ser Pro Val Glu Glu Ser Ala Leu Arg Leu His Gly Ser Ala Phe Arg
        835                 840                 845             
Pro Ser Leu Pro Ala Pro Glu Ser Pro Gly Leu Pro Ala His Pro Ser
    850                 855                 860                 
Asn Pro Gln Leu Pro Glu Ala Arg Pro Gly Ile Pro Gly Gly Thr Ala
865                 870                 875                 880 
Ser Leu Leu Glu Pro Thr Ser Gly Trp Gly Thr Ser Cys Thr Gly Cys
                885                 890                 895     
Arg Pro Pro Ser Lys Lys Pro Ser Thr Phe Thr Val Cys Trp Ser Pro
            900                 905                 910         
Val Ala Arg Trp Thr Pro Gly Ser Ser Arg His Gly Leu Ser Trp Ser
        915                 920                 925             
Pro Pro Ser Cys Gly Ser Thr Ala Ser Trp Arg Leu Asn Ala Trp Trp
    930                 935                 940                 
Gly Leu Val Trp Pro Gln Pro Arg Leu Cys Pro Ala Gln Asp Pro Arg
945                 950                 955                 960 
Pro His Arg Arg Cys Thr Pro Trp Pro Ala Gln Thr Cys Arg Pro Cys
                965                 970                 975     
Trp Asn Thr Thr Arg Ser Cys Trp Cys Arg Pro Cys Gly Gly Arg His
            980                 985                 990         
Gly Gly Thr Glu Gly Ala Ala Pro Pro Pro Gln Pro Cys Cys Phe
        995                 1000                1005        


<210> 7754
<211> 1534
<212> PRT
<213> Homo sapiens

<400> 7754
Thr Asn Val Pro Ser Ser Pro Lys Lys Ser Ser Ser Asp Phe Tyr Ser
 1               5                  10                  15      
Arg Glu Leu Ile Phe Arg Met Ser Val Asn Ile Ser Thr Ala Gly Lys
            20                  25                  30          
Gly Val Asp Pro Asn Thr Val Asp Thr Tyr Asp Ser Gly Asp Asp Trp
        35                  40                  45              
Glu Ile Gly Val Gly Asn Leu Ile Ile Asp Leu Asp Ala Asp Leu Glu
    50                  55                  60                  
Lys Asp Arg Gln Lys Phe Glu Met Asn Asn Ser Thr Thr Thr Thr Ser
65                  70                  75                  80  
Ser Ser Asn Ser Lys Asp Cys Gly Gly Pro Ala Ser Ser Gly Ala Gly
                85                  90                  95      
Ala Thr Ala Ala Leu Ala Asp Gly Leu Lys Phe Ala Ser Val Gln Ala
            100                 105                 110         
Ser Ala Pro Gln Gly Asn Ser His Lys Glu Thr Ser Lys Ser Lys Val
        115                 120                 125             
Lys Arg Ser Lys Thr Ser Lys Asp Ala Asn Lys Ser Leu Pro Ser Ala
    130                 135                 140                 
Ala Leu Tyr Gly Ile Pro Glu Ile Ser Ser Thr Gly Lys Arg Gln Glu
145                 150                 155                 160 
Val Gln Gly Arg Pro Gly Glu Ala Thr Gly Met Asn Ser Ala Leu Gly
                165                 170                 175     
Gln Ser Val Ser Ser Gly Gly Ser Gly Asn Pro Asn Ser Asn Ser Thr
            180                 185                 190         
Ser Thr Ser Thr Ser Ala Ala Thr Ala Gly Ala Gly Ser Cys Gly Lys
        195                 200                 205             
Ser Lys Glu Glu Lys Pro Gly Lys Ser Gln Ser Ser Arg Gly Ala Lys
    210                 215                 220                 
Arg Asp Lys Asp Ala Gly Lys Ser Arg Lys Asp Lys His Asp Leu Leu
225                 230                 235                 240 
Gln Gly His Gln Asn Gly Ser Gly Ser Gln Ala Pro Ser Gly Gly His
                245                 250                 255     
Leu Tyr Gly Phe Gly Ala Lys Ser Asn Gly Gly Gly Ala Ser Pro Phe
            260                 265                 270         
His Cys Gly Gly Thr Gly Ser Gly Ser Val Ala Ala Ala Gly Glu Val
        275                 280                 285             
Ser Lys Ser Ala Pro Asp Ser Gly Leu Met Gly Asn Ser Met Leu Val
    290                 295                 300                 
Lys Lys Glu Glu Glu Glu Glu Glu Ser His Arg Arg Ile Lys Lys Leu
305                 310                 315                 320 
Lys Thr Glu Lys Val Asp Pro Leu Phe Thr Val Pro Ala Pro Pro Pro
                325                 330                 335     
Pro Ile Ser Ser Ser Leu Thr Pro Gln Ile Leu Pro Ser Tyr Phe Ser
            340                 345                 350         
Pro Ser Ser Ser Asn Ile Ala Ala Pro Val Glu Gln Leu Leu Val Arg
        355                 360                 365             
Thr Arg Ser Val Gly Val Asn Thr Cys Glu Val Gly Val Val Thr Glu
    370                 375                 380                 
Pro Glu Cys Leu Gly Pro Cys Glu Pro Gly Thr Ser Val Asn Leu Glu
385                 390                 395                 400 
Gly Ile Val Trp His Glu Thr Glu Glu Gly Val Leu Val Val Asn Val
                405                 410                 415     
Thr Trp Arg Asn Lys Thr Tyr Val Gly Thr Leu Leu Asp Cys Thr Lys
            420                 425                 430         
His Asp Trp Ala Pro Pro Arg Phe Cys Glu Ser Pro Thr Ser Asp Leu
        435                 440                 445             
Glu Met Arg Gly Gly Arg Gly Arg Gly Lys Arg Ala Arg Ser Ala Ala
    450                 455                 460                 
Ala Ala Pro Gly Ser Glu Ala Ser Phe Thr Glu Ser Arg Gly Leu Gln
465                 470                 475                 480 
Asn Lys Asn Arg Gly Gly Ala Asn Gly Lys Gly Arg Arg Gly Ser Leu
                485                 490                 495     
Asn Ala Ser Gly Arg Arg Thr Pro Pro Asn Cys Ala Ala Glu Asp Ile
            500                 505                 510         
Lys Ala Ser Pro Ser Ser Thr Asn Lys Arg Lys Asn Lys Pro Pro Met
        515                 520                 525             
Glu Leu Asp Leu Asn Ser Ser Ser Glu Asp Asn Lys Pro Gly Lys Arg
    530                 535                 540                 
Val Arg Thr Asn Ser Arg Ser Thr Pro Thr Thr Pro Gln Gly Lys Pro
545                 550                 555                 560 
Glu Thr Thr Phe Leu Asp Gln Gly Cys Ser Ser Pro Val Leu Ile Asp
                565                 570                 575     
Cys Pro His Pro Asn Cys Asn Lys Lys Tyr Lys His Ile Asn Gly Leu
            580                 585                 590         
Arg Tyr His Gln Ala His Ala His Leu Asp Pro Glu Asn Lys Leu Glu
        595                 600                 605             
Phe Glu Pro Asp Ser Glu Asp Lys Ile Ser Asp Cys Glu Glu Gly Leu
    610                 615                 620                 
Ser Asn Val Ala Leu Glu Cys Ser Glu Pro Ser Thr Ser Val Ser Ala
625                 630                 635                 640 
Tyr Asp Gln Leu Lys Ala Pro Ala Ser Pro Gly Ala Gly Asn Pro Pro
                645                 650                 655     
Gly Thr Pro Lys Gly Lys Arg Glu Leu Met Ser Asn Gly Pro Gly Ser
            660                 665                 670         
Ile Ile Gly Ala Lys Ala Gly Lys Asn Ser Gly Lys Lys Lys Gly Leu
        675                 680                 685             
Asn Asn Glu Leu Asn Asn Leu Pro Val Ile Ser Asn Met Thr Ala Ala
    690                 695                 700                 
Leu Asp Ser Cys Ser Ala Ala Asp Gly Ser Leu Ala Ala Glu Met Pro
705                 710                 715                 720 
Lys Leu Glu Ala Glu Gly Leu Ile Asp Lys Lys Asn Leu Gly Asp Lys
                725                 730                 735     
Glu Lys Gly Lys Lys Ala Asn Asn Cys Lys Thr Asp Lys Asn Leu Ser
            740                 745                 750         
Lys Leu Lys Ser Ala Arg Pro Ile Ala Pro Ala Pro Ala Pro Thr Pro
        755                 760                 765             
Pro Gln Leu Ile Ala Ile Pro Thr Ala Thr Phe Thr Thr Thr Thr Thr
    770                 775                 780                 
Gly Thr Ile Pro Gly Leu Pro Ser Leu Thr Thr Thr Val Val Gln Ala
785                 790                 795                 800 
Thr Pro Lys Ser Pro Pro Leu Lys Pro Ile Gln Pro Lys Pro Thr Ile
                805                 810                 815     
Met Gly Glu Pro Ile Thr Val Asn Pro Ala Leu Val Ser Leu Lys Asp
            820                 825                 830         
Lys Lys Lys Lys Glu Lys Arg Lys Leu Lys Asp Lys Glu Gly Lys Glu
        835                 840                 845             
Thr Gly Ser Pro Lys Met Asp Ala Lys Leu Gly Lys Leu Glu Asp Ser
    850                 855                 860                 
Lys Gly Ala Ser Lys Asp Leu Pro Gly His Phe Leu Lys Asp His Leu
865                 870                 875                 880 
Asn Lys Asn Glu Gly Leu Ala Asn Gly Leu Ser Glu Ser Gln Glu Ser
                885                 890                 895     
Arg Met Ala Ser Ile Lys Ala Glu Ala Asp Lys Val Tyr Thr Phe Thr
            900                 905                 910         
Asp Asn Ala Pro Ser Pro Ser Ile Gly Ser Ala Ser Arg Leu Glu Cys
        915                 920                 925             
Ser Thr Leu Val Asn Gly Gln Ala Pro Met Ala Pro Leu His Val Leu
    930                 935                 940                 
Thr Gln Asn Gly Ala Glu Ser Ser Ala Ala Lys Thr Ser Ser Pro Ala
945                 950                 955                 960 
Tyr Ser Asp Ile Ser Asp Ala Ala Asp Asp Gly Gly Ser Asp Ser Arg
                965                 970                 975     
Ser Glu Gly Met Arg Ser Lys Ala Ser Ser Pro Ser Asp Ile Ile Ser
            980                 985                 990         
Ser Lys Asp Ser Val Val Lys Gly His Ser Ser Thr Thr Ala Gln Ser
        995                 1000                1005            
Ser Gln Leu Lys Glu Ser His Ser Pro Tyr Tyr His Ser Tyr Asp Pro
    1010                1015                1020                
Tyr Tyr Ser Pro Ser Tyr Met His Pro Gly Gln Val Gly Ala Pro Ala
1025                1030                1035                1040
Ala Gly Asn Ser Gly Ser Thr Gln Gly Met Lys Ile Lys Lys Glu Ser
                1045                1050                1055    
Glu Glu Asp Ala Glu Lys Lys Asp Lys Ala Glu Gln Leu Asp Ser Lys
            1060                1065                1070        
Lys Val Asp His Asn Ser Ala Ser Leu Gln Pro Gln His Gln Ser Val
        1075                1080                1085            
Ile Thr Gln Arg His Pro Ala Leu Ala Gln Ser Leu Tyr Tyr Gly Gln
    1090                1095                1100                
Tyr Ala Tyr Gly Leu Tyr Met Asp Gln Lys Ser Leu Met Ala Thr Ser
1105                1110                1115                1120
Pro Ala Tyr Arg Gln Gln Tyr Glu Lys Tyr Tyr Glu Asp Gln Arg Leu
                1125                1130                1135    
Ala Glu Gln Lys Met Ala Gln Thr Gly Arg Gly Asp Cys Glu Arg Lys
            1140                1145                1150        
Ser Glu Leu Pro Leu Lys Glu Leu Gly Lys Glu Glu Thr Lys Gln Lys
        1155                1160                1165            
Asn Met Pro Ser Ala Thr Ile Ser Lys Ala Pro Ser Thr Pro Glu Pro
    1170                1175                1180                
Asn Lys Asn His Ser Lys Leu Gly Pro Ser Val Pro Asn Lys Thr Glu
1185                1190                1195                1200
Glu Thr Gly Lys Ser Gln Leu Leu Ser Asn His Gln Gln Gln Leu Gln
                1205                1210                1215    
Ala Asp Ser Phe Lys Ala Lys Gln Met Glu Asn His Gln Leu Ile Lys
            1220                1225                1230        
Glu Ala Val Glu Met Lys Ser Val Met Asp Ser Met Lys Gln Thr Gly
        1235                1240                1245            
Val Asp Pro Thr Ser Arg Phe Lys Gln Asp Pro Asp Ser Arg Thr Trp
    1250                1255                1260                
His His Tyr Val Tyr Gln Pro Lys Tyr Leu Asp Gln Gln Lys Ser Glu
1265                1270                1275                1280
Glu Leu Asp Arg Glu Lys Lys Leu Lys Glu Asp Ser Pro Arg Lys Thr
                1285                1290                1295    
Pro Asn Lys Glu Ser Gly Val Pro Ser Leu Pro Val Ser Leu Thr Ser
            1300                1305                1310        
Ile Lys Glu Glu Pro Lys Glu Ala Lys His Pro Asp Ser Gln Ser Met
        1315                1320                1325            
Glu Glu Ser Lys Leu Lys Asn Asp Asp Arg Lys Thr Pro Val Asn Trp
    1330                1335                1340                
Lys Asp Ser Arg Gly Thr Arg Val Ala Val Ser Ser Pro Met Ser Gln
1345                1350                1355                1360
His Gln Ser Tyr Ile Gln Tyr Leu His Ala Tyr Pro Tyr Pro Gln Met
                1365                1370                1375    
Tyr Asp Pro Ser His Pro Ala Tyr Arg Ala Val Ser Pro Val Leu Met
            1380                1385                1390        
His Ser Tyr Pro Gly Ala Tyr Leu Ser Pro Gly Phe His Tyr Pro Val
        1395                1400                1405            
Tyr Gly Lys Met Ser Gly Arg Glu Glu Thr Glu Lys Val Asn Thr Ser
    1410                1415                1420                
Pro Ser Val Asn Thr Lys Thr Thr Thr Glu Ser Lys Ala Leu Asp Leu
1425                1430                1435                1440
Leu Gln Gln His Ala Asn Gln Tyr Arg Ser Lys Ser Pro Ala Pro Val
                1445                1450                1455    
Glu Lys Ala Thr Ala Glu Arg Glu Arg Glu Ala Glu Arg Glu Arg Asp
            1460                1465                1470        
Arg His Ser Pro Phe Gly Gln Arg His Leu His Thr His His His Thr
        1475                1480                1485            
His Val Gly Met Gly Tyr Pro Leu Ile Pro Gly Gln Tyr Asp Pro Phe
    1490                1495                1500                
Gln Gly Leu Thr Ser Ala Ala Leu Val Ala Ser Gln Gln Val Ala Ala
1505                1510                1515                1520
Gln Ala Ser Ala Ser Gly Met Phe Pro Gly Gln Arg Arg Glu
                1525                1530                


<210> 7755
<211> 146
<212> PRT
<213> Homo sapiens

<400> 7755
Gly Arg Val Gly Gly Arg Val Gly Gly Arg Val Gly Gly Thr Leu Thr
 1               5                  10                  15      
Arg Thr Ser Asp Ser Glu Val Pro Asp Val Glu Ser Arg Glu Asp Leu
            20                  25                  30          
Ile Lys Asn His Tyr Met Ala Arg Ile Val Glu Leu Thr Ser Gln Leu
        35                  40                  45              
Gln Leu Ala Asp Ser Lys Ser Val His Phe Tyr Ala Glu Cys Arg Ala
    50                  55                  60                  
Leu Ser Lys Arg Leu Ala Leu Ala Glu Lys Ser Lys Glu Ala Leu Thr
65                  70                  75                  80  
Glu Glu Met Lys Leu Ala Ser Gln Asn Ile Ser Arg Leu Gln Asp Glu
                85                  90                  95      
Leu Thr Thr Thr Lys Arg Ser Tyr Glu Asp Gln Leu Ser Met Met Ser
            100                 105                 110         
Asp His Leu Cys Ser Met Asn Glu Thr Leu Ser Lys Gln Arg Glu Glu
        115                 120                 125             
Ile Asp Thr Leu Lys Met Ser Ser Lys Gly Asn Ser Lys Lys Asn Lys
    130                 135                 140                 
Ser Arg
145     


<210> 7756
<211> 798
<212> PRT
<213> Homo sapiens

<400> 7756
Pro Val Pro Gly Ser Val Ser Gly Phe Gly Gly Gly Arg Gln Ala Glu
 1               5                  10                  15      
Pro Pro Gly Arg Pro Gly Leu Tyr Gly Ala Gly Glu Ala Met Ala Ser
            20                  25                  30          
Ala Glu Leu Gln Gly Lys Tyr Gln Lys Leu Ala Gln Glu Tyr Ser Lys
        35                  40                  45              
Leu Arg Ala Gln Asn Gln Val Leu Lys Lys Gly Val Val Asp Glu Gln
    50                  55                  60                  
Ala Asn Ser Ala Ala Leu Lys Glu Gln Leu Lys Met Lys Asp Gln Ser
65                  70                  75                  80  
Leu Arg Lys Leu Gln Gln Glu Met Asp Ser Leu Thr Phe Arg Asn Leu
                85                  90                  95      
Gln Leu Ala Lys Arg Val Glu Leu Leu Gln Asp Glu Leu Ala Leu Ser
            100                 105                 110         
Glu Pro Arg Gly Lys Lys Asn Lys Lys Ser Gly Glu Ser Ser Ser Gln
        115                 120                 125             
Leu Ser Gln Glu Gln Lys Ser Val Phe Asp Glu Asp Leu Gln Lys Lys
    130                 135                 140                 
Ile Glu Glu Asn Glu Arg Leu His Ile Gln Phe Phe Glu Ala Asp Glu
145                 150                 155                 160 
Gln His Lys His Val Glu Ala Glu Leu Arg Ser Arg Leu Ala Thr Leu
                165                 170                 175     
Glu Thr Glu Ala Ala Gln His Gln Ala Val Val Asp Gly Leu Thr Arg
            180                 185                 190         
Lys Tyr Met Glu Thr Ile Glu Lys Leu Gln Asn Asp Lys Ala Lys Leu
        195                 200                 205             
Glu Val Lys Ser Gln Thr Leu Glu Lys Glu Ala Lys Glu Cys Arg Leu
    210                 215                 220                 
Arg Thr Glu Glu Cys Gln Leu Gln Leu Lys Thr Leu His Glu Asp Leu
225                 230                 235                 240 
Ser Gly Arg Leu Glu Glu Ser Leu Ser Ile Ile Asn Glu Lys Val Pro
                245                 250                 255     
Phe Asn Asp Thr Lys Tyr Ser Gln Tyr Asn Ala Leu Asn Val Pro Leu
            260                 265                 270         
His Asn Arg Arg His Gln Leu Lys Met Arg Asp Ile Ala Gly Gln Ala
        275                 280                 285             
Leu Ala Phe Val Gln Asp Leu Val Thr Ala Leu Leu Asn Phe His Thr
    290                 295                 300                 
Tyr Thr Glu Gln Arg Ile Gln Ile Phe Pro Val Asp Ser Ala Ile Asp
305                 310                 315                 320 
Thr Ile Ser Pro Leu Asn Gln Lys Phe Ser Gln Tyr Leu His Glu Asn
                325                 330                 335     
Ala Ser Tyr Val Arg Pro Leu Glu Glu Gly Met Leu His Leu Phe Glu
            340                 345                 350         
Ser Ile Thr Glu Asp Thr Val Thr Val Leu Glu Thr Thr Val Lys Leu
        355                 360                 365             
Lys Thr Phe Ser Glu His Leu Thr Ser Tyr Ile Cys Phe Leu Arg Lys
    370                 375                 380                 
Ile Leu Pro Tyr Gln Leu Lys Ser Leu Glu Glu Glu Cys Glu Ser Ser
385                 390                 395                 400 
Leu Cys Thr Ser Ala Leu Arg Ala Arg Asn Leu Glu Leu Ser Gln Asp
                405                 410                 415     
Met Lys Lys Met Thr Ala Val Phe Glu Lys Leu Gln Thr Tyr Ile Ala
            420                 425                 430         
Leu Leu Ala Leu Pro Ser Thr Glu Pro Asp Gly Leu Leu Arg Thr Asn
        435                 440                 445             
Tyr Ser Ser Val Leu Thr Asn Val Gly Ala Ala Leu His Gly Phe His
    450                 455                 460                 
Asp Val Met Lys Asp Ile Ser Lys His Tyr Ser Gln Lys Ala Ala Ile
465                 470                 475                 480 
Glu His Glu Leu Pro Thr Ala Thr Gln Lys Leu Ile Thr Thr Asn Asp
                485                 490                 495     
Cys Ile Leu Ser Ser Val Val Ala Leu Thr Asn Gly Ala Gly Lys Ile
            500                 505                 510         
Ala Ser Phe Phe Ser Asn Asn Leu Asp Tyr Phe Ile Ala Ser Leu Ser
        515                 520                 525             
Tyr Gly Pro Lys Ala Ala Ser Gly Phe Ile Ser Pro Leu Ser Ala Glu
    530                 535                 540                 
Cys Met Leu Gln Tyr Lys Lys Lys Ala Ala Ala Tyr Met Lys Ser Leu
545                 550                 555                 560 
Arg Lys Pro Leu Leu Glu Ser Val Pro Tyr Glu Glu Ala Leu Ala Asn
                565                 570                 575     
Arg Arg Ile Leu Leu Ser Ser Thr Glu Ser Arg Glu Gly Leu Ala Gln
            580                 585                 590         
Gln Val Gln Gln Ser Leu Glu Lys Ile Ser Lys Leu Glu Gln Glu Lys
        595                 600                 605             
Glu His Trp Met Leu Glu Ala Gln Leu Ala Lys Ile Lys Leu Glu Lys
    610                 615                 620                 
Glu Asn Gln Arg Ile Ala Asp Lys Leu Lys Asn Thr Gly Ser Ala Gln
625                 630                 635                 640 
Leu Val Gly Leu Ala Gln Glu Asn Ala Ala Val Ser Asn Thr Ala Gly
                645                 650                 655     
Gln Asp Glu Ala Thr Ala Lys Ala Val Leu Glu Pro Ile Gln Ser Thr
            660                 665                 670         
Ser Leu Val Pro Asp Val Glu Ser Arg Glu Asp Leu Ile Lys Asn His
        675                 680                 685             
Tyr Met Ala Arg Ile Val Glu Leu Thr Ser Gln Leu Gln Leu Ala Asp
    690                 695                 700                 
Ser Lys Ser Val His Phe Tyr Ala Glu Cys Arg Ala Leu Ser Lys Arg
705                 710                 715                 720 
Leu Ala Leu Ala Glu Lys Ser Lys Glu Ala Leu Thr Glu Glu Met Lys
                725                 730                 735     
Leu Ala Ser Gln Asn Ile Ser Arg Leu Gln Asp Glu Leu Thr Thr Thr
            740                 745                 750         
Lys Arg Ser Tyr Glu Asp Gln Leu Ser Met Met Ser Asp His Leu Cys
        755                 760                 765             
Ser Met Asn Glu Thr Leu Ser Lys Gln Arg Glu Glu Ile Asp Thr Leu
    770                 775                 780                 
Lys Met Ser Ser Lys Gly Asn Ser Lys Lys Asn Lys Ser Arg
785                 790                 795             


<210> 7757
<211> 447
<212> PRT
<213> Homo sapiens

<400> 7757
Val Pro Thr Lys Lys Asn Phe Ser Ile Leu Ala Arg Asn Leu Asn Thr
 1               5                  10                  15      
Ile Gln Val Glu Glu Met Ser Ala Cys Asn Ile Ser Ile Gln Gly Pro
            20                  25                  30          
Ser Ile Tyr Asn Lys Glu Pro Lys Asn Ile Ile Asn Pro His Glu Lys
        35                  40                  45              
Val Gln Met Lys Ser Ile Cys Ala Asn Ser Pro Ile Lys Ala Gln Gln
    50                  55                  60                  
Asp Gln Leu Gln Val Lys Asn Asn Ile Lys Ala Ser Leu His Asn Val
65                  70                  75                  80  
Lys Ser Ser Leu Pro Leu Phe Asn Thr Lys Ser Ser Thr Ser Val Gly
                85                  90                  95      
Gln Leu Gln Ser Pro Thr Leu Asn Ser Pro Ile Cys Met Gln Lys Gln
            100                 105                 110         
Gly Lys Asn Glu His Leu Ala Phe Asn Thr Lys Ser Lys Ala Ser Thr
        115                 120                 125             
Val Gly Ser Glu Leu Val Leu Val Ser Thr Thr Val Pro Thr Val His
    130                 135                 140                 
His Val Ser Asp Leu Glu Met Ser Ser Thr Leu Asp Cys Leu Pro Val
145                 150                 155                 160 
Leu Ala Asp Trp Glu Asp Val Val Leu Leu Pro Ala Ser Gln Pro Glu
                165                 170                 175     
Glu Asn Val Asp Cys Thr Val Pro Ile Ser Asp Ser Asp Leu Glu Ile
            180                 185                 190         
Ser Phe Asn Ser Gly Glu Arg Leu Met Val Leu Lys Glu Leu Glu Met
        195                 200                 205             
Ser Ser His Glu Asn Phe Gly Asp Ile Glu Glu Thr Pro Gln Lys Ser
    210                 215                 220                 
Glu Thr Ser Lys Ser Ile Val Tyr Lys Ser Pro His Thr Thr Ile Tyr
225                 230                 235                 240 
Asn Val Lys Glu Ala Lys Asp Pro Gly Ser Asp Ile Ser Ala Phe Lys
                245                 250                 255     
Leu Pro Glu His Lys Ser Ser Thr Phe Asn Arg Val Asn Ala Asn Met
            260                 265                 270         
Ser His Pro Leu Val Leu Gly Lys His Pro Leu Leu Ser Gly Gly Thr
        275                 280                 285             
Lys Arg Asn Pro Cys Ser Pro Gln Ala Phe Pro Pro Ala Lys Lys Gln
    290                 295                 300                 
Pro Phe Thr Ile His Glu Glu Lys Pro Thr Ser Ser Asp Cys Ser Pro
305                 310                 315                 320 
Val Arg Ser Ser Ser Trp Arg Arg Leu Pro Ser Ile Leu Thr Ser Thr
                325                 330                 335     
Val Asn Leu Gln Glu Pro Trp Lys Ser Gly Lys Met Thr Pro Pro Leu
            340                 345                 350         
Cys Lys Cys Gly Arg Arg Ser Lys Arg Leu Val Val Ser Asn Asn Gly
        355                 360                 365             
Pro Asn His Gly Lys Val Phe Tyr Cys Cys Pro Ile Gly Lys Tyr Gln
    370                 375                 380                 
Glu Asn Arg Lys Cys Cys Gly Tyr Phe Lys Trp Glu Gln Thr Leu Gln
385                 390                 395                 400 
Lys Glu Arg Ala Asn Ser Met Val Pro Ser His Ser Thr Gly Gly Leu
                405                 410                 415     
Thr Phe Ser Ser Pro Glu Thr Ser His Ile Cys Asp Arg Asn Leu Ser
            420                 425                 430         
Ile Ser Thr Lys Asn Ser Leu Arg Leu Arg Pro Ser Met Arg Asn
        435                 440                 445         


<210> 7758
<211> 264
<212> PRT
<213> Homo sapiens

<400> 7758
Met Glu Ala Phe Leu Gly Ser Arg Ser Gly Leu Trp Ala Gly Gly Pro
 1               5                  10                  15      
Ala Pro Gly Gln Phe Tyr Arg Ile Pro Ser Thr Pro Asp Ser Phe Met
            20                  25                  30          
Asp Pro Ala Ser Ala Leu Tyr Arg Gly Pro Ile Thr Arg Thr Gln Asn
        35                  40                  45              
Pro Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Glu Gly Gly
    50                  55                  60                  
Val Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg
65                  70                  75                  80  
Phe Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asn Ser Thr Met Leu
                85                  90                  95      
Gly Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu
            100                 105                 110         
Gly Gln Met Val Ile Asp Glu Glu Leu Leu Gly Asp Gly His Ser Tyr
        115                 120                 125             
Ser Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg
    130                 135                 140                 
Arg Ser Lys Met Asn Pro Leu Trp Asn Thr Met Val Ile Gly Gly Tyr
145                 150                 155                 160 
Ala Asp Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala
                165                 170                 175     
Tyr Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln
            180                 185                 190         
Pro Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr
        195                 200                 205             
Glu Ala Arg Asp Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg
    210                 215                 220                 
Asp Ala Arg Ser Tyr Asn Arg Phe Gln Thr Ala Thr Val Thr Glu Lys
225                 230                 235                 240 
Gly Val Glu Ile Glu Gly Pro Leu Ser Thr Glu Thr Asn Trp Asp Ile
                245                 250                 255     
Ala His Met Ile Ser Gly Phe Glu
            260                 


<210> 7759
<211> 308
<212> PRT
<213> Homo sapiens

<400> 7759
Met Arg Ser Phe Leu Gln Gln Asp Val Asn Lys Thr Lys Ser Arg Leu
 1               5                  10                  15      
Asn Val Leu Asn Gly Leu Ala Asn Asn Met Asp Asp Leu Lys Ile Asn
            20                  25                  30          
Thr Asp Ile Thr Gly Ala Lys Glu Glu Leu Leu Asp Asp Asn Asn Phe
        35                  40                  45              
Ile Ser Asp Lys Glu Ser Gly Val His Lys Pro Lys Asp Cys Gln Thr
    50                  55                  60                  
Ser Phe Gln Lys Asn Asn Thr Leu Thr Leu Pro Glu Glu Leu Ser Lys
65                  70                  75                  80  
Asp Lys Ser Glu Asn Ala Leu Ser Gly Gly Gln Ser Ser Leu Phe Ile
                85                  90                  95      
His Ala Gly Ala Pro Thr Val Ser Ser Glu Asn Phe Ile Leu Pro Lys
            100                 105                 110         
Gly Ala Ala Val Asn Gly Pro Val Ser His Ser Ser Leu Thr Lys Thr
        115                 120                 125             
Ser Asn Met Asn Lys Gly Ser Val Ser Leu Thr Thr Gly Gln Pro Val
    130                 135                 140                 
Asp Gln Pro Thr Thr Glu Ser Cys Ser Thr Leu Lys Val Ala Ala Asp
145                 150                 155                 160 
Leu Gln Leu Ser Thr Pro Gln Lys Ala Ser Gln His Gln Val Leu Phe
                165                 170                 175     
Leu Leu Ser Asp Val Ala His Ala Lys Asn Pro Thr His Ser Asn Lys
            180                 185                 190         
Lys Leu Pro Thr Ser Ala Ser Val Gly Cys Asp Ile Gln Asn Ser Val
        195                 200                 205             
Gly Ser Asn Ile Lys Ser Asp Gly Thr Leu Ile Asn Gln Val Glu Val
    210                 215                 220                 
Gly Glu Asp Gly Glu Asp Leu Leu Val Lys Asp Asp Cys Val Asn Thr
225                 230                 235                 240 
Val Thr Gly Ile Ser Ser Gly Thr Asp Gly Phe Arg Ser Glu Asn Asp
                245                 250                 255     
Thr Asn Trp Asp Pro Gln Lys Glu Phe Ile Gln Phe Leu Met Thr Asn
            260                 265                 270         
Glu Glu Thr Val Asp Lys Ala Pro Pro His Ser Lys Ile Gly Leu Glu
        275                 280                 285             
Lys Lys Lys Lys Ala Lys Asn Gly Cys Lys Gln Asp Asn Ser Leu Tyr
    290                 295                 300                 
Arg Gly Leu Leu
305             


<210> 7760
<211> 526
<212> PRT
<213> Homo sapiens

<400> 7760
Met Asp Val Arg Phe Tyr Pro Pro Pro Ala Gln Pro Ala Ala Ala Pro
 1               5                  10                  15      
Asp Ala Pro Cys Leu Gly Pro Ser Pro Cys Leu Asp Pro Tyr Tyr Cys
            20                  25                  30          
Asn Lys Phe Asp Gly Glu Asn Met Tyr Met Ser Met Thr Glu Pro Ser
        35                  40                  45              
Gln Asp Tyr Val Pro Ala Ser Gln Ser Tyr Pro Gly Pro Ser Leu Glu
    50                  55                  60                  
Ser Glu Asp Phe Asn Ile Pro Pro Ile Thr Pro Pro Ser Leu Pro Asp
65                  70                  75                  80  
His Ser Leu Val His Leu Asn Glu Val Glu Ser Gly Tyr His Ser Leu
                85                  90                  95      
Cys His Pro Met Asn His Asn Gly Leu Leu Pro Phe His Pro Gln Asn
            100                 105                 110         
Met Asp Leu Pro Glu Ile Thr Val Ser Asn Met Leu Gly Gln Asp Gly
        115                 120                 125             
Thr Leu Leu Ser Asn Ser Ile Ser Val Met Pro Asp Ile Arg Asn Pro
    130                 135                 140                 
Glu Gly Thr Gln Tyr Ser Ser His Pro Gln Met Ala Ala Met Arg Pro
145                 150                 155                 160 
Arg Gly Gln Pro Ala Asp Ile Arg Gln Gln Pro Gly Met Met Pro His
                165                 170                 175     
Gly Gln Leu Thr Thr Ile Asn Gln Ser Gln Leu Ser Ala Gln Leu Gly
            180                 185                 190         
Leu Asn Met Gly Gly Ser Asn Val Pro His Asn Ser Pro Ser Pro Pro
        195                 200                 205             
Gly Ser Lys Ser Ala Thr Pro Ser Pro Ser Ser Ser Val His Glu Asp
    210                 215                 220                 
Glu Gly Asp Asp Thr Ser Lys Ile Asn Gly Gly Glu Lys Arg Pro Ala
225                 230                 235                 240 
Ser Asp Met Gly Lys Lys Pro Lys Thr Pro Lys Lys Lys Lys Lys Lys
                245                 250                 255     
Asp Pro Asn Glu Pro Gln Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe
            260                 265                 270         
Arg Asp Thr Gln Ala Ala Ile Lys Gly Gln Asn Pro Asn Ala Thr Phe
        275                 280                 285             
Gly Glu Val Ser Lys Ile Val Ala Ser Met Trp Asp Gly Leu Gly Glu
    290                 295                 300                 
Glu Gln Lys Gln Val Tyr Lys Lys Lys Thr Glu Ala Ala Lys Lys Glu
305                 310                 315                 320 
Tyr Leu Lys Gln Leu Ala Ala Tyr Arg Ala Ser Leu Val Ser Lys Ser
                325                 330                 335     
Tyr Ser Glu Pro Val Asp Val Lys Thr Ser Gln Pro Pro Gln Leu Ile
            340                 345                 350         
Asn Ser Lys Pro Ser Val Phe His Gly Pro Ser Gln Ala His Ser Ala
        355                 360                 365             
Leu Tyr Leu Ser Ser His Tyr His Gln Gln Pro Gly Met Asn Pro His
    370                 375                 380                 
Leu Thr Ala Met His Pro Ser Leu Pro Arg Asn Ile Ala Pro Lys Pro
385                 390                 395                 400 
Asn Asn Gln Met Pro Val Thr Val Ser Ile Ala Asn Met Ala Val Ser
                405                 410                 415     
Pro Pro Pro Pro Leu Gln Ile Ser Pro Pro Leu His Gln His Leu Asn
            420                 425                 430         
Met Gln Gln His Gln Pro Leu Thr Met Gln Gln Pro Leu Gly Asn Gln
        435                 440                 445             
Leu Pro Met Gln Val Gln Ser Ala Leu His Ser Pro Thr Met Gln Gln
    450                 455                 460                 
Gly Phe Thr Leu Gln Pro Asp Tyr Gln Thr Ile Ile Asn Pro Thr Ser
465                 470                 475                 480 
Thr Ala Ala Gln Val Val Thr Gln Ala Met Glu Tyr Val Arg Ser Gly
                485                 490                 495     
Cys Arg Asn Pro Pro Pro Gln Pro Val Asp Trp Asn Asn Asp Tyr Cys
            500                 505                 510         
Ser Ser Gly Gly Met Gln Arg Asp Lys Ala Leu Tyr Leu Thr
        515                 520                 525     


<210> 7761
<211> 407
<212> PRT
<213> Homo sapiens

<400> 7761
Met Gly Lys Glu Asn Ile Pro Gly Asp Phe Leu Cys Ile Ser Leu Val
 1               5                  10                  15      
Asn Ser Ser Val Gln Leu Arg Tyr Asn Leu Gly Asp Arg Thr Ile Ile
            20                  25                  30          
Leu Glu Thr Leu Gln Lys Val Thr Ile Asn Gly Ser Thr Trp His Ile
        35                  40                  45              
Ile Lys Ala Gly Arg Val Gly Ala Glu Gly Tyr Leu Asp Leu Asp Gly
    50                  55                  60                  
Ile Asn Val Thr Glu Lys Ala Ser Thr Lys Met Ser Ser Leu Asp Thr
65                  70                  75                  80  
Asn Thr Asp Phe Tyr Ile Gly Gly Val Ser Ser Leu Asn Leu Val Asn
                85                  90                  95      
Pro Met Ala Ile Glu Asn Glu Pro Val Gly Phe Gln Gly Cys Ile Arg
            100                 105                 110         
Gln Val Ile Ile Asn Asn Gln Glu Leu Gln Leu Thr Glu Phe Gly Ala
        115                 120                 125             
Lys Gly Gly Ser Asn Val Gly Asp Cys Asp Gly Thr Ala Cys Gly Tyr
    130                 135                 140                 
Asn Thr Cys Arg Asn Gly Gly Glu Cys Thr Val Asn Gly Thr Thr Phe
145                 150                 155                 160 
Ser Cys Arg Cys Leu Pro Asp Trp Ala Gly Asn Thr Cys Asn Gln Ser
                165                 170                 175     
Val Ser Cys Leu Asn Asn Leu Cys Leu His Gln Ser Leu Cys Ile Pro
            180                 185                 190         
Asp Gln Ser Phe Ser Tyr Ser Cys Leu Cys Thr Leu Gly Trp Val Gly
        195                 200                 205             
Arg Tyr Cys Glu Asn Lys Thr Ser Phe Ser Thr Ala Lys Phe Met Gly
    210                 215                 220                 
Asn Ser Tyr Ile Lys Tyr Ile Asp Pro Asn Tyr Arg Met Arg Asn Leu
225                 230                 235                 240 
Gln Phe Thr Thr Ile Ser Leu Asn Phe Ser Thr Thr Lys Thr Glu Gly
                245                 250                 255     
Leu Ile Val Trp Met Gly Ile Ala Gln Asn Glu Glu Asn Asp Phe Leu
            260                 265                 270         
Ala Ile Gly Leu His Asn Gln Thr Leu Lys Ile Ala Val Asn Leu Gly
        275                 280                 285             
Glu Arg Ile Ser Val Pro Met Ser Tyr Asn Asn Gly Thr Phe Cys Cys
    290                 295                 300                 
Asn Lys Trp His His Val Val Val Ile Gln Asn Gln Thr Leu Ile Lys
305                 310                 315                 320 
Ala Tyr Ile Asn Asn Ser Leu Ile Leu Ser Glu Asp Ile Asp Pro His
                325                 330                 335     
Lys Asn Phe Val Ala Leu Asn Tyr Asp Gly Ile Cys Tyr Leu Gly Gly
            340                 345                 350         
Phe Glu Tyr Gly Arg Lys Val Asn Ile Val Thr Gln Glu Ile Phe Lys
        355                 360                 365             
Thr Asn Phe Val Gly Lys Ile Lys Asp Val Val Phe Phe Gln Glu Pro
    370                 375                 380                 
Lys Asn Ile Glu Leu Ile Lys Leu Glu Gly Tyr Asn Val Tyr Asp Gly
385                 390                 395                 400 
Asp Glu Gln Asn Glu Val Thr
                405         


<210> 7762
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 7762
Met Ala Lys Arg Lys Glu Glu Asn Phe Ser Ser Pro Lys Asn Ala Lys
 1               5                  10                  15      
Arg Pro Arg Gln Glu Glu Leu Glu Asp Phe Asp Lys Asp Gly Asp Glu
            20                  25                  30          
Asp Glu Cys Lys Gly Thr Thr Leu Thr Ala Ala Glu Val Gly Ile Ile
        35                  40                  45              
Glu Ser Ile His Leu Lys Asn Phe Met Cys His Ser Met Leu Gly Pro
    50                  55                  60                  
Phe Lys Phe Gly Ser Asn Val Asn Phe Val Val Gly Asn Asn Gly Ser
65                  70                  75                  80  
Gly Lys Ser Ala Val Leu Thr Ala Leu Ile Val Gly Leu Gly Gly Arg
                85                  90                  95      
Ala Val Ala Thr Asn Arg Gly Ser Ser Leu Lys Gly Phe Val Lys Asp
            100                 105                 110         
Gly Gln Asn Ser Ala Asp Ile Ser Ile Thr Leu Arg Asn Arg Gly Asp
        115                 120                 125             
Asp Ala Phe Lys Ala Ser Val Tyr Gly Asn Ser Ile Leu Ile Gln Gln
    130                 135                 140                 
His Ile Ser Ile Asp Gly Ser Arg Ser Tyr Lys Leu Lys Ser Ala Thr
145                 150                 155                 160 
Gly Ser Val Val Ser Thr Arg Lys Glu Glu Leu Ile Ala Ile Leu Asp
                165                 170                 175     
His Phe Asn Ile Gln Val Asp Asn Pro Val Ser Val Leu Thr Gln Glu
            180                 185                 190         
Met Ser Lys Gln Phe Leu Gln Ser Lys Asn Glu Gly Asp Lys Tyr Lys
        195                 200                 205             
Phe Phe Met Lys Ala Thr Gln Leu Glu Gln Met Lys Glu Asp Tyr Ser
    210                 215                 220                 
Tyr Ile Met Glu Thr Lys Glu Arg Thr Lys Glu Gln Ile His Gln Gly
225                 230                 235                 240 
Glu Glu Arg Leu Thr Glu Leu Lys Arg Gln Cys Val Glu Lys Glu Glu
                245                 250                 255     
Arg Phe Gln Ser Ile Ala Gly Leu Ser Thr Met Lys Thr Asn Leu Glu
            260                 265                 270         
Ser Leu Lys His Glu Met Ala Trp Ala Val Val Asn Glu Ile Glu Lys
        275                 280                 285             
Gln Leu Asn Ala Ile Arg Asp Asn Ile Lys Ile Gly Glu Asp Arg Ala
    290                 295                 300                 
Ala Arg Leu Asp Arg Lys Met Glu Glu Gln Gln Val Arg Leu Asn Glu
305                 310                 315                 320 
Ala Glu Gln Lys Tyr Lys Asp Ile Gln Asp Lys Leu Glu Lys Ile Ser
                325                 330                 335     
Glu Glu Thr Asn Ala Arg Ala Pro Glu Cys Met Ala Leu Lys Ala Asp
            340                 345                 350         
Val Val Ala Lys Lys Arg Ala Tyr Asn Glu Ala Glu Val Leu Tyr Asn
        355                 360                 365             
Arg Ser Leu Asn Glu Tyr Lys Ala Leu Lys Lys Asp Asp Glu Gln Leu
    370                 375                 380                 
Cys Lys Arg Ile Glu Glu Leu Lys Lys Ser Thr Asp Gln Ser Leu Glu
385                 390                 395                 400 
Pro Glu Arg Leu Glu Arg Gln Lys Lys Ile Ser Trp Leu Lys Glu Arg
                405                 410                 415     
Val Lys Ala Phe Gln Asn Gln Glu Asn Ser Val Asn Gln Glu Ile Glu
            420                 425                 430         
Gln Phe Gln Gln Ala Ile Glu Lys Asp Lys Glu Glu His Gly Lys Ile
        435                 440                 445             
Lys Arg Glu Glu Leu Asp Val Lys His Ala Leu Ser Tyr Asn Gln Arg
    450                 455                 460                 
Gln Leu Lys Glu Leu Lys Asp Ser Lys Thr Asp Arg Leu Lys Arg Phe
465                 470                 475                 480 
Gly Pro Asn Val Pro Ala Leu Leu Glu Ala Ile Asp Asp Ala Tyr Arg
                485                 490                 495     
Gln Gly His Phe Thr Tyr Lys Pro Val Gly Pro Leu Gly Ala Cys Ile
            500                 505                 510         
His Leu Arg Asp Pro Glu Leu Ala Leu Ala Ile Glu Ser Cys Leu Lys
        515                 520                 525             
Gly Leu Leu Gln Ala Tyr Cys Cys His Asn His Ala Asp Glu Arg Val
    530                 535                 540                 
Leu Gln Ala Leu Met Lys Arg Phe Tyr Leu Pro Gly Thr Ser Arg Pro
545                 550                 555                 560 
Pro Ile Ile Val Ser Glu Phe Arg Asn Glu Ile Tyr Asp Val Arg His
                565                 570                 575     
Arg Ala Ala Tyr His Pro Asp Phe Pro Thr Val Leu Thr Ala Leu Glu
            580                 585                 590         
Ile Asp Asn Ala Val Val Ala Asn Ser Leu Ile Asp Met Arg Gly Ile
        595                 600                 605             
Glu Thr Val Leu Leu Ile Lys Asn Asn Ser Val Ala Arg Ala Val Met
    610                 615                 620                 
Gln Ser Gln Lys Pro Pro Lys Asn Cys Arg Glu Ala Phe Thr Ala Asp
625                 630                 635                 640 
Gly Asp Gln Val Phe Ala Gly Arg Tyr Tyr Ser Ser Glu Asn Thr Arg
                645                 650                 655     
Pro Lys Phe Leu Ser Arg Asp Val Asp Ser Glu Ile Ser Asp Leu Glu
            660                 665                 670         
Asn Glu Val Glu Asn Lys Thr Ala Gln Ile Leu Asn Leu Gln Gln His
        675                 680                 685             
Leu Ser Ala Leu Glu Lys Asp Ile Lys His Asn Glu Glu Leu Leu Lys
    690                 695                 700                 
Arg Cys Gln Leu His Tyr Lys Glu Leu Lys Met Lys Ile Arg Lys Asn
705                 710                 715                 720 
Ile Ser Glu Ile Arg Glu Leu Glu Asn Ile Glu Glu His Gln Ser Val
                725                 730                 735     
Asp Ile Ala Thr Leu Glu Asp Glu Ala Gln Glu Asn Lys Ser Lys Met
            740                 745                 750         
Lys Met Val Glu Glu His Met Glu Gln Gln Lys Glu Asn Met Glu His
        755                 760                 765             
Leu Lys Ser Leu Lys Ile Glu Ala Glu Asn Lys Tyr Asp Ala Ile Lys
    770                 775                 780                 
Phe Lys Ile Asn Gln Leu Ser Glu Leu Ala Asp Pro Leu Lys Asp Glu
785                 790                 795                 800 
Leu Asn Leu Ala Asp Ser Glu Val Asp Asn Gln Lys Arg Gly Lys Arg
                805                 810                 815     
His Tyr Glu Glu Lys Gln Lys Glu His Leu Asp Thr Leu Asn Lys Lys
            820                 825                 830         
Lys Arg Glu Leu Asp Met Lys Glu Lys Glu Leu Glu Glu Lys Met Ser
        835                 840                 845             
Gln Ala Arg Gln Ile Cys Pro Glu Arg Ile Glu Val Glu Lys Ser Ala
    850                 855                 860                 
Ser Ile Leu Asp Lys Glu Ile Asn Arg Leu Arg Gln Lys Ile Gln Ala
865                 870                 875                 880 
Glu His Ala Ser His Gly Asp Arg Glu Glu Ile Met Arg Gln Tyr Gln
                885                 890                 895     
Glu Ala Arg Glu Thr Tyr Leu Asp Leu Asp Ser Lys Val Arg Thr Leu
            900                 905                 910         
Lys Lys Phe Ile Lys Leu Leu Gly Glu Ile Met Glu His Arg Phe Lys
        915                 920                 925             
Thr Tyr Gln Gln Phe Arg Arg Cys Leu Thr Leu Arg Cys Lys Leu Tyr
    930                 935                 940                 
Phe Asp Asn Leu Leu Ser Gln Arg Ala Tyr Cys Gly Lys Met Asn Phe
945                 950                 955                 960 
Asp His Lys Asn Glu Thr Leu Ser Ile Ser Val Gln Pro Gly Glu Gly
                965                 970                 975     
Asn Lys Ala Ala Phe Asn Asp Met Arg Ala Leu Ser Gly Gly Glu Arg
            980                 985                 990         
Ser Phe Ser Thr Val Cys Phe Ile Leu Ser Leu Trp Ser Ile Ala Glu
        995                 1000                1005            
Ser Pro Phe Arg Cys Leu Asp Glu Phe Asp Val Tyr Met Asp Met Val
    1010                1015                1020                
Asn Arg Arg Ile Ala Met Asp Leu Ile Leu Lys Met Ala Asp Ser Gln
1025                1030                1035                1040
Arg Phe Arg Gln Phe Ile Leu Leu Thr Pro Gln Ser Met Ser Ser Leu
                1045                1050                1055    
Pro Ser Ser Lys Leu Ile Arg Ile Leu Arg Met Ser Asp Pro Glu Arg
            1060                1065                1070        
Gly Gln Thr Thr Leu Pro Phe Arg Pro Val Thr Gln Glu Glu Asp Asp
        1075                1080                1085            
Asp Gln Arg
    1090    


<210> 7763
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 7763
Met Ala Lys Arg Lys Glu Glu Asn Phe Ser Ser Pro Lys Asn Ala Lys
 1               5                  10                  15      
Arg Pro Arg Gln Glu Glu Leu Glu Asp Phe Asp Lys Asp Gly Asp Glu
            20                  25                  30          
Asp Glu Cys Lys Gly Thr Thr Leu Thr Ala Ala Glu Val Gly Ile Ile
        35                  40                  45              
Glu Ser Ile His Leu Lys Asn Phe Met Cys His Ser Met Leu Gly Pro
    50                  55                  60                  
Phe Lys Phe Gly Ser Asn Val Asn Phe Val Val Gly Asn Asn Gly Ser
65                  70                  75                  80  
Gly Lys Ser Ala Val Leu Thr Ala Leu Ile Val Gly Leu Gly Gly Arg
                85                  90                  95      
Ala Val Ala Thr Asn Arg Gly Ser Ser Leu Lys Gly Phe Val Lys Asp
            100                 105                 110         
Gly Gln Asn Ser Ala Asp Ile Ser Ile Thr Leu Arg Asn Arg Gly Asp
        115                 120                 125             
Asp Ala Phe Lys Ala Ser Val Tyr Gly Asn Ser Ile Leu Ile Gln Gln
    130                 135                 140                 
His Ile Ser Ile Asp Gly Ser Arg Ser Tyr Lys Leu Lys Ser Ala Thr
145                 150                 155                 160 
Gly Ser Val Val Ser Thr Arg Lys Glu Glu Leu Ile Ala Ile Leu Asp
                165                 170                 175     
His Phe Asn Ile Gln Val Asp Asn Pro Val Ser Val Leu Thr Gln Glu
            180                 185                 190         
Met Ser Lys Gln Phe Leu Gln Ser Lys Asn Glu Gly Asp Lys Tyr Lys
        195                 200                 205             
Phe Phe Met Lys Ala Thr Gln Leu Glu Gln Met Lys Glu Asp Tyr Ser
    210                 215                 220                 
Tyr Ile Met Glu Thr Lys Glu Arg Thr Lys Glu Gln Ile His Gln Gly
225                 230                 235                 240 
Glu Glu Arg Leu Thr Glu Leu Lys Arg Gln Cys Val Glu Lys Glu Glu
                245                 250                 255     
Arg Phe Gln Ser Ile Ala Gly Leu Ser Thr Met Lys Thr Asn Leu Glu
            260                 265                 270         
Ser Leu Lys His Glu Met Ala Trp Ala Val Val Asn Glu Ile Glu Lys
        275                 280                 285             
Gln Leu Asn Ala Ile Arg Asp Asn Ile Lys Ile Gly Glu Asp Arg Ala
    290                 295                 300                 
Ala Arg Leu Asp Arg Lys Met Glu Glu Gln Gln Val Arg Leu Asn Glu
305                 310                 315                 320 
Ala Glu Gln Lys Tyr Lys Asp Ile Gln Asp Lys Leu Glu Lys Ile Ser
                325                 330                 335     
Glu Glu Thr Asn Ala Arg Ala Pro Glu Cys Met Ala Leu Lys Ala Asp
            340                 345                 350         
Val Val Ala Lys Lys Arg Ala Tyr Asn Glu Ala Glu Val Leu Tyr Asn
        355                 360                 365             
Arg Ser Leu Asn Glu Tyr Lys Ala Leu Lys Lys Asp Asp Glu Gln Leu
    370                 375                 380                 
Cys Lys Arg Ile Glu Glu Leu Lys Lys Ser Thr Asp Gln Ser Leu Glu
385                 390                 395                 400 
Pro Glu Arg Leu Glu Arg Gln Lys Lys Ile Ser Trp Leu Lys Glu Arg
                405                 410                 415     
Val Lys Ala Phe Gln Asn Gln Glu Asn Ser Val Asn Gln Glu Ile Glu
            420                 425                 430         
Gln Phe Gln Gln Ala Ile Glu Lys Asp Lys Glu Glu His Gly Lys Ile
        435                 440                 445             
Lys Arg Glu Glu Leu Asp Val Lys His Ala Leu Ser Tyr Asn Gln Gly
    450                 455                 460                 
Gln Leu Lys Glu Leu Lys Asp Ser Lys Thr Asp Arg Leu Lys Arg Phe
465                 470                 475                 480 
Gly Pro Asn Val Pro Ala Leu Leu Glu Ala Ile Asp Asp Ala Tyr Arg
                485                 490                 495     
Gln Gly His Phe Thr Tyr Lys Pro Val Gly Pro Leu Gly Ala Cys Ile
            500                 505                 510         
His Leu Arg Asp Pro Glu Leu Ala Leu Ala Ile Glu Ser Cys Leu Lys
        515                 520                 525             
Gly Leu Leu Gln Ala Tyr Cys Cys His Asn His Ala Asp Glu Arg Val
    530                 535                 540                 
Leu Gln Ala Leu Met Lys Arg Phe Tyr Leu Pro Gly Thr Ser Arg Pro
545                 550                 555                 560 
Pro Ile Ile Val Ser Glu Phe Arg Asn Glu Ile Tyr Asp Val Arg His
                565                 570                 575     
Arg Ala Ala Tyr His Pro Asp Phe Pro Thr Val Leu Thr Ala Leu Glu
            580                 585                 590         
Ile Asp Asn Ala Val Val Ala Asn Ser Leu Ile Asp Met Arg Gly Ile
        595                 600                 605             
Glu Thr Val Leu Leu Ile Lys Asn Asn Ser Val Ala Arg Ala Val Met
    610                 615                 620                 
Gln Ser Gln Lys Pro Pro Lys Asn Cys Arg Glu Ala Phe Thr Ala Asp
625                 630                 635                 640 
Gly Asp Gln Val Phe Ala Gly Arg Tyr Tyr Ser Ser Glu Asn Thr Arg
                645                 650                 655     
Pro Lys Phe Leu Ser Arg Asp Val Asp Ser Glu Ile Ser Asp Leu Glu
            660                 665                 670         
Asn Glu Val Glu Asn Lys Thr Ala Gln Ile Leu Asn Leu Gln Gln His
        675                 680                 685             
Leu Ser Thr Leu Glu Lys Asp Ile Lys His Asn Glu Glu Leu Leu Lys
    690                 695                 700                 
Arg Cys Gln Leu His Tyr Lys Glu Leu Lys Met Lys Ile Arg Lys Asn
705                 710                 715                 720 
Ile Ser Glu Ile Arg Glu Leu Glu Asn Ile Glu Glu His Gln Ser Val
                725                 730                 735     
Asp Ile Ala Thr Leu Glu Asp Glu Ala Gln Glu Asn Lys Ser Lys Met
            740                 745                 750         
Lys Met Val Glu Glu His Met Glu Gln Gln Lys Glu Asn Met Glu His
        755                 760                 765             
Leu Lys Ser Leu Lys Ile Glu Ala Glu Asn Lys Tyr Asp Ala Ile Lys
    770                 775                 780                 
Phe Lys Ile Asn Gln Leu Ser Glu Leu Ala Asp Pro Leu Lys Asp Glu
785                 790                 795                 800 
Leu Asn Leu Ala Asp Ser Glu Val Asp Asn Gln Lys Arg Gly Lys Arg
                805                 810                 815     
His Tyr Glu Glu Lys Gln Lys Glu His Leu Asp Thr Leu Asn Lys Lys
            820                 825                 830         
Lys Arg Glu Leu Asp Met Lys Glu Lys Glu Leu Glu Glu Lys Met Ser
        835                 840                 845             
Gln Ala Arg Gln Ile Cys Pro Glu Arg Ile Glu Val Glu Lys Ser Ala
    850                 855                 860                 
Ser Ile Leu Asp Lys Glu Ile Asn Arg Leu Arg Gln Lys Ile Gln Ala
865                 870                 875                 880 
Glu His Ala Ser His Gly Asp Arg Glu Glu Ile Met Arg Gln Tyr Gln
                885                 890                 895     
Glu Ala Arg Glu Thr Tyr Leu Asp Leu Asp Ser Lys Val Arg Thr Leu
            900                 905                 910         
Lys Lys Phe Ile Lys Leu Leu Gly Glu Ile Met Glu His Arg Phe Lys
        915                 920                 925             
Thr Tyr Gln Gln Phe Arg Arg Cys Leu Thr Leu Arg Cys Lys Leu Tyr
    930                 935                 940                 
Phe Asp Asn Leu Leu Ser Gln Arg Ala Tyr Cys Gly Lys Met Asn Phe
945                 950                 955                 960 
Asp His Lys Asn Glu Thr Leu Ser Ile Ser Val Gln Pro Gly Glu Gly
                965                 970                 975     
Asn Lys Ala Ala Phe Asn Asp Met Arg Ala Leu Ser Gly Gly Glu Arg
            980                 985                 990         
Ser Phe Ser Thr Val Cys Phe Ile Leu Ser Leu Trp Ser Ile Ala Glu
        995                 1000                1005            
Ser Pro Phe Arg Cys Leu Asp Glu Phe Asp Val Tyr Met Asp Met Val
    1010                1015                1020                
Asn Arg Arg Ile Ala Met Asp Leu Ile Leu Lys Met Ala Asp Ser Gln
1025                1030                1035                1040
Arg Phe Arg Gln Phe Ile Leu Leu Thr Pro Gln Ser Met Ser Ser Leu
                1045                1050                1055    
Pro Ser Ser Lys Leu Ile Arg Ile Leu Arg Met Ser Asp Pro Glu Arg
            1060                1065                1070        
Gly Gln Thr Thr Leu Pro Phe Arg Pro Val Thr Gln Glu Glu Asp Asp
        1075                1080                1085            
Asp Gln Arg
    1090    


<210> 7764
<211> 132
<212> PRT
<213> Homo sapiens

<400> 7764
Met Gln Thr Thr Asp Leu Glu Gln Thr Ser Pro Pro Val Asn Gln Ala
 1               5                  10                  15      
Pro Asn Gln Thr Lys Leu Glu Val Lys Ala Pro Pro Arg Trp Leu Val
            20                  25                  30          
Leu Leu Leu Gly Gln His Ser Pro Pro Phe Pro Gln Pro Pro Ile Ser
        35                  40                  45              
Pro Val Ser Leu Lys Lys Pro Glu Pro Cys Pro Ile Cys Thr Ser Ser
    50                  55                  60                  
Val Gly Leu Ser Gly Ala Leu Gly Ser Lys Glu Arg Val Arg Ser Pro
65                  70                  75                  80  
Ala Pro Phe Leu Pro Pro Thr Leu Phe Leu Thr Asn Ser Trp Thr Val
                85                  90                  95      
Pro Ala Met Arg Leu Arg Thr Gly Ala Met Leu Gly Cys Val Arg Asp
            100                 105                 110         
Thr Asp His Gly Gly Gln Arg Asp Thr Glu Gly Asp Cys Ser Ala Thr
        115                 120                 125             
Arg Glu Leu Thr
    130         


<210> 7765
<211> 140
<212> PRT
<213> Homo sapiens

<400> 7765
Met Gln Arg Leu Asn Ile Gly Tyr Val Ile Asn Val Thr Thr His Leu
 1               5                  10                  15      
Pro Leu Tyr His Tyr Glu Lys Gly Leu Phe Asn Tyr Lys Arg Leu Pro
            20                  25                  30          
Ala Thr Asp Ser Asn Lys Gln Asn Leu Arg Gln Tyr Phe Glu Glu Ala
        35                  40                  45              
Phe Glu Phe Ile Glu Glu Ala His Gln Cys Gly Lys Gly Leu Leu Ile
    50                  55                  60                  
His Cys Gln Ala Gly Val Ser Arg Ser Ala Thr Ile Val Ile Ala Tyr
65                  70                  75                  80  
Leu Met Lys His Thr Arg Met Thr Met Thr Asp Ala Tyr Lys Phe Val
                85                  90                  95      
Lys Gly Lys Arg Pro Ile Ile Ser Pro Asn Leu Asn Phe Met Gly Gln
            100                 105                 110         
Leu Leu Glu Phe Glu Glu Asp Leu Asn Asn Gly Val Thr Pro Arg Ile
        115                 120                 125             
Leu Thr Pro Lys Leu Met Gly Val Glu Thr Val Val
    130                 135                 140 


<210> 7766
<211> 482
<212> PRT
<213> Homo sapiens

<400> 7766
Met Pro Pro Ser Pro Leu Asp Asp Arg Val Val Val Ala Leu Ser Arg
 1               5                  10                  15      
Pro Val Arg Pro Gln Asp Leu Asn Leu Cys Leu Asp Ser Ser Tyr Leu
            20                  25                  30          
Gly Ser Ala Asn Pro Gly Ser Asn Ser His Pro Pro Val Ile Ala Thr
        35                  40                  45              
Thr Val Val Ser Leu Lys Ala Ala Asn Leu Thr Tyr Met Pro Ser Ser
    50                  55                  60                  
Ser Gly Ser Ala Arg Ser Leu Asn Cys Gly Cys Ser Ser Ala Ser Cys
65                  70                  75                  80  
Cys Thr Val Ala Thr Tyr Asp Lys Asp Asn Gln Ala Gln Thr Gln Ala
                85                  90                  95      
Ile Ala Ala Gly Thr Thr Thr Thr Ala Ile Gly Thr Ser Thr Thr Cys
            100                 105                 110         
Pro Ala Asn Gln Met Val Asn Asn Asn Glu Asn Thr Gly Ser Leu Ser
        115                 120                 125             
Pro Ser Ser Gly Val Gly Ser Pro Val Ser Gly Thr Pro Lys Gln Leu
    130                 135                 140                 
Ala Ser Ile Lys Ile Ile Tyr Pro Asn Asp Leu Ala Lys Lys Met Thr
145                 150                 155                 160 
Lys Cys Ser Lys Ser His Leu Pro Ser Gln Gly Pro Val Ile Ile Asp
                165                 170                 175     
Cys Arg Pro Phe Met Glu Tyr Asn Lys Ser His Ile Gln Gly Ala Val
            180                 185                 190         
His Ile Asn Cys Ala Asp Lys Ile Ser Arg Arg Arg Leu Gln Gln Gly
        195                 200                 205             
Lys Ile Thr Val Leu Asp Leu Ile Ser Cys Arg Glu Gly Lys Asp Ser
    210                 215                 220                 
Phe Lys Arg Ile Phe Ser Lys Glu Ile Ile Val Tyr Asp Glu Asn Thr
225                 230                 235                 240 
Asn Glu Pro Ser Arg Val Met Pro Ser Gln Pro Leu His Ile Val Leu
                245                 250                 255     
Glu Ser Leu Lys Arg Glu Gly Lys Glu Pro Leu Val Leu Lys Gly Gly
            260                 265                 270         
Leu Ser Ser Phe Lys Gln Asn His Glu Asn Leu Cys Asp Asn Ser Leu
        275                 280                 285             
Gln Leu Gln Glu Cys Arg Glu Val Gly Gly Gly Ala Ser Ala Ala Ser
    290                 295                 300                 
Ser Leu Leu Pro Gln Pro Ile Pro Thr Thr Pro Asp Ile Glu Asn Ala
305                 310                 315                 320 
Glu Leu Thr Pro Ile Leu Pro Phe Leu Phe Leu Gly Asn Glu Gln Asp
                325                 330                 335     
Ala Gln Asp Leu Asp Thr Met Gln Arg Leu Asn Ile Gly Tyr Val Ile
            340                 345                 350         
Asn Val Thr Thr His Leu Pro Leu Tyr His Tyr Glu Lys Gly Leu Phe
        355                 360                 365             
Asn Tyr Lys Arg Leu Pro Ala Thr Asp Ser Asn Lys Gln Asn Leu Arg
    370                 375                 380                 
Gln Tyr Phe Glu Glu Ala Phe Glu Phe Ile Glu Glu Ala His Gln Cys
385                 390                 395                 400 
Gly Lys Gly Leu Leu Ile His Cys Gln Ala Gly Val Ser Arg Ser Ala
                405                 410                 415     
Thr Ile Val Ile Ala Tyr Leu Met Lys His Thr Arg Met Thr Met Thr
            420                 425                 430         
Asp Ala Tyr Lys Phe Val Lys Gly Lys Arg Pro Ile Ile Ser Pro Asn
        435                 440                 445             
Leu Asn Phe Met Gly Gln Leu Leu Glu Phe Glu Glu Asp Leu Asn Asn
    450                 455                 460                 
Gly Val Thr Pro Arg Ile Leu Thr Pro Lys Leu Met Gly Val Glu Thr
465                 470                 475                 480 
Val Val
        


<210> 7767
<211> 557
<212> PRT
<213> Homo sapiens

<400> 7767
Met Asp Ser Asp Glu Gly Tyr Asn Tyr Glu Phe Asp Glu Asp Glu Glu
 1               5                  10                  15      
Cys Ser Glu Glu Asp Ser Gly Ala Glu Glu Glu Glu Asp Glu Asp Asp
            20                  25                  30          
Asp Glu Pro Asp Asp Asp Thr Leu Asp Leu Gly Glu Val Glu Leu Val
        35                  40                  45              
Glu Pro Gly Leu Gly Val Gly Gly Glu Arg Asp Gly Leu Leu Cys Gly
    50                  55                  60                  
Glu Thr Gly Gly Gly Gly Gly Ser Ala Leu Gly Pro Gly Gly Gly Gly
65                  70                  75                  80  
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro Gly His Glu Gln Glu
                85                  90                  95      
Glu Asp Tyr Arg Tyr Glu Val Leu Thr Ala Glu Gln Ile Leu Gln His
            100                 105                 110         
Met Val Glu Cys Ile Arg Glu Val Asn Glu Val Ile Gln Asn Pro Ala
        115                 120                 125             
Thr Ile Thr Arg Ile Leu Leu Ser His Phe Asn Trp Asp Lys Glu Lys
    130                 135                 140                 
Leu Met Glu Arg Tyr Phe Asp Gly Asn Leu Glu Lys Leu Phe Ala Glu
145                 150                 155                 160 
Cys His Val Ile Asn Pro Ser Lys Lys Ser Arg Thr Arg Gln Met Asn
                165                 170                 175     
Thr Arg Ser Ser Ala Gln Asp Met Pro Cys Gln Ile Cys Tyr Leu Asn
            180                 185                 190         
Tyr Pro Asn Ser Tyr Phe Thr Gly Leu Glu Cys Gly His Lys Phe Cys
        195                 200                 205             
Met Gln Cys Trp Ser Glu Tyr Leu Thr Thr Lys Ile Met Glu Glu Gly
    210                 215                 220                 
Met Gly Gln Thr Ile Ser Cys Pro Ala His Gly Cys Asp Ile Leu Val
225                 230                 235                 240 
Asp Asp Asn Thr Val Met Arg Leu Ile Thr Asp Ser Lys Val Lys Leu
                245                 250                 255     
Lys Tyr Gln His Leu Ile Thr Asn Ser Phe Val Glu Cys Asn Arg Leu
            260                 265                 270         
Leu Lys Trp Cys Pro Ala Pro Asp Cys His His Val Val Lys Val Gln
        275                 280                 285             
Tyr Pro Asp Ala Lys Pro Val Arg Cys Lys Cys Gly Arg Gln Phe Cys
    290                 295                 300                 
Phe Asn Cys Gly Glu Asn Trp His Asp Pro Val Lys Cys Lys Trp Leu
305                 310                 315                 320 
Lys Lys Trp Ile Lys Lys Cys Asp Asp Asp Ser Glu Thr Ser Asn Trp
                325                 330                 335     
Ile Ala Ala Asn Thr Lys Glu Cys Pro Lys Cys His Val Thr Ile Glu
            340                 345                 350         
Lys Asp Gly Gly Cys Asn His Met Val Cys Arg Asn Gln Asn Cys Lys
        355                 360                 365             
Ala Glu Phe Cys Trp Val Cys Leu Gly Pro Trp Glu Pro His Gly Ser
    370                 375                 380                 
Ala Trp Tyr Asn Cys Asn Arg Tyr Asn Glu Asp Asp Ala Lys Ala Ala
385                 390                 395                 400 
Arg Asp Ala Gln Glu Arg Ser Arg Ala Ala Leu Gln Arg Tyr Leu Phe
                405                 410                 415     
Tyr Cys Asn Arg Tyr Met Asn His Met Gln Ser Leu Arg Phe Glu His
            420                 425                 430         
Lys Leu Tyr Ala Gln Val Lys Gln Lys Met Glu Glu Met Gln Gln His
        435                 440                 445             
Asn Met Ser Trp Ile Glu Val Gln Phe Leu Lys Lys Ala Val Asp Val
    450                 455                 460                 
Leu Cys Gln Cys Arg Ala Thr Leu Met Tyr Thr Tyr Val Phe Ala Phe
465                 470                 475                 480 
Tyr Leu Lys Lys Asn Asn Gln Ser Ile Ile Phe Glu Asn Asn Gln Ala
                485                 490                 495     
Asp Leu Glu Asn Ala Thr Glu Val Leu Ser Gly Tyr Leu Glu Arg Asp
            500                 505                 510         
Ile Ser Gln Asp Ser Leu Gln Asp Ile Lys Gln Lys Val Gln Asp Lys
        515                 520                 525             
Tyr Arg Tyr Cys Glu Ser Arg Arg Arg Val Leu Leu Gln His Val His
    530                 535                 540                 
Glu Gly Tyr Glu Lys Asp Leu Trp Glu Tyr Ile Glu Asp
545                 550                 555         


<210> 7768
<211> 356
<212> PRT
<213> Homo sapiens

<400> 7768
Met Thr Leu Val Leu Ser Met Asn Arg Phe Cys Glu Pro Ile Val Ser
 1               5                  10                  15      
Glu Gly Ala Ala Glu Ile Ala Gly Tyr Gln Thr Leu Trp Glu Ala Asp
            20                  25                  30          
Ser Tyr Gly Gly Pro Ser Pro Pro Gly Pro Ala Gln Ala Pro Leu Gln
        35                  40                  45              
Gly Asp Arg Gly Ala Gly Pro Pro Leu Ala Gly Ser His Tyr Arg Gly
    50                  55                  60                  
Ile Ser Asn Pro Ile Thr Thr Ser Lys Ile Thr Tyr Phe Lys Arg Lys
65                  70                  75                  80  
Tyr Val Glu Glu Glu Asp Phe His Pro Pro Leu Ser Ser Cys Ser His
                85                  90                  95      
Lys Thr Ile Ser Ile Phe Glu Glu Arg Ala His Ile Leu Tyr Met Ser
            100                 105                 110         
Leu Glu Lys Leu Lys Phe Ile Asp Asp Pro Glu Val Tyr Leu Arg Arg
        115                 120                 125             
Ser Val Leu Ile Asn Asn Leu Met Lys Arg Ile His Gly Glu Ile Ile
    130                 135                 140                 
Met Gln Asn Asn Trp Cys Phe Pro Ala Cys Ser Phe Asn Gly Thr Ser
145                 150                 155                 160 
Ala Gln Glu Trp Phe Met Ala Gln Asp Cys Pro Tyr Arg Lys Arg Pro
                165                 170                 175     
Arg Met Ala Lys Glu Glu Cys Glu Lys Phe His Ala Cys Cys Phe Tyr
            180                 185                 190         
Gln Glu Cys Gly Gly His Tyr Leu Asn Leu Pro Leu Ser Val Asn Ala
        195                 200                 205             
Asn Val Gly Ser Ala Ser Thr Ala Ala Ser Ser Pro Ser Ala Ser Ser
    210                 215                 220                 
Ser Ser Ser Ser Ser Ser Ser Ser Pro Pro Leu Pro Leu Pro Ser Cys
225                 230                 235                 240 
Ser Arg Gln Val Asp Phe Asp Val Gly Ser Ala Ser Ile Tyr Lys Ser
                245                 250                 255     
Asp Gly Gln Ile Pro Ala Asn Glu Ile Phe Val Thr Asn Val Arg Ser
            260                 265                 270         
Leu Gly Val Gln Glu Lys Ala Lys Leu Asn Asp Glu Lys Ala Asn Asp
        275                 280                 285             
Asp Thr Asn Arg Asp Gly Gly Pro Leu Ser His Glu Pro Val Gly Asn
    290                 295                 300                 
Asp Leu Ala Phe Glu Cys Lys Gly Gln Phe Tyr Asp Tyr Phe Glu Thr
305                 310                 315                 320 
Gly Tyr Asn Glu Arg Asn Asn Val Asn Glu Ser Trp Lys Lys Ser Leu
                325                 330                 335     
Arg Lys Lys Glu Ala Ser Pro Pro Ser Asn Lys Leu Cys Cys Ser Lys
            340                 345                 350         
Gly Ser Lys Ile
        355     


<210> 7769
<211> 251
<212> PRT
<213> Homo sapiens

<400> 7769
Met Gln Lys Ser Thr Asn Ser Asp Thr Ser Val Glu Thr Leu Asn Ser
 1               5                  10                  15      
Thr Arg Gln Gly Thr Gly Ala Val Gln Met Arg Ile Lys Asn Ala Asn
            20                  25                  30          
Ser His His Asp Arg Leu Ser Gln Ser Lys Ser Met Ile Leu Thr Asp
        35                  40                  45              
Val Gly Lys Val Thr Glu Pro Ile Ser Arg His Arg Arg Asn His Ser
    50                  55                  60                  
Gln His Ile Leu Lys Asp Val Ile Pro Pro Leu Glu Gln Leu Met Val
65                  70                  75                  80  
Glu Lys Glu Gly Tyr Leu Gln Lys Ala Lys Ile Ala Asp Gly Gly Lys
                85                  90                  95      
Lys Leu Arg Lys Asn Trp Ser Thr Ser Trp Ile Val Leu Ser Ser Arg
            100                 105                 110         
Arg Ile Glu Phe Tyr Lys Glu Ser Lys Gln Gln Ala Leu Ser Asn Met
        115                 120                 125             
Lys Thr Gly His Lys Pro Glu Ser Val Asp Leu Cys Gly Ala His Ile
    130                 135                 140                 
Glu Trp Ala Lys Glu Lys Ser Ser Arg Lys Asn Val Phe Gln Ile Thr
145                 150                 155                 160 
Thr Val Ser Gly Asn Glu Phe Leu Leu Gln Ser Asp Ile Asp Phe Ile
                165                 170                 175     
Ile Leu Asp Trp Phe His Ala Ile Lys Asn Ala Ile Asp Arg Leu Pro
            180                 185                 190         
Lys Asp Ser Ser Cys Pro Ser Arg Asn Leu Glu Leu Phe Lys Ile Gln
        195                 200                 205             
Arg Ser Ser Ser Thr Glu Leu Leu Ser His Tyr Asp Ser Asp Ile Lys
    210                 215                 220                 
Glu Gln Lys Pro Glu His Arg Lys Ser Phe Asn Val Gln Thr Ala Ser
225                 230                 235                 240 
Gln Cys Phe Arg Tyr Lys Arg Gln Lys Ser Ser
                245                 250     


<210> 7770
<211> 475
<212> PRT
<213> Homo sapiens

<400> 7770
Met Gln Lys Ser Thr Asn Ser Asp Thr Ser Val Glu Thr Leu Asn Ser
 1               5                  10                  15      
Thr Arg Gln Gly Thr Gly Ala Val Gln Met Arg Ile Lys Asn Ala Asn
            20                  25                  30          
Ser His His Asp Arg Leu Ser Gln Ser Lys Ser Met Ile Leu Thr Asp
        35                  40                  45              
Val Gly Lys Val Thr Glu Pro Ile Ser Arg His Arg Arg Asn His Ser
    50                  55                  60                  
Gln His Ile Leu Lys Asp Val Ile Pro Pro Leu Glu Gln Leu Met Val
65                  70                  75                  80  
Glu Lys Glu Gly Tyr Leu Gln Lys Ala Lys Ile Ala Asp Gly Gly Lys
                85                  90                  95      
Lys Leu Arg Lys Asn Trp Ser Thr Ser Trp Ile Val Leu Ser Ser Arg
            100                 105                 110         
Arg Ile Glu Phe Tyr Lys Glu Ser Lys Gln Gln Ala Leu Ser Asn Met
        115                 120                 125             
Lys Thr Gly His Lys Pro Glu Ser Val Asp Leu Cys Gly Ala His Ile
    130                 135                 140                 
Glu Trp Ala Lys Glu Lys Ser Ser Arg Lys Asn Val Phe Gln Ile Thr
145                 150                 155                 160 
Thr Val Ser Gly Asn Glu Phe Leu Leu Gln Ser Asp Ile Asp Phe Ile
                165                 170                 175     
Ile Leu Asp Trp Phe His Ala Ile Lys Asn Ala Ile Asp Arg Leu Pro
            180                 185                 190         
Lys Asp Ser Ser Cys Pro Ser Arg Asn Leu Glu Leu Phe Lys Ile Gln
        195                 200                 205             
Arg Ser Ser Ser Thr Glu Leu Leu Ser His Tyr Asp Ser Asp Ile Lys
    210                 215                 220                 
Glu Gln Lys Pro Glu His Arg Lys Ser Leu Met Phe Arg Leu His His
225                 230                 235                 240 
Ser Ala Ser Asp Thr Ser Asp Lys Asn Arg Val Lys Ser Arg Leu Lys
                245                 250                 255     
Lys Phe Ile Thr Arg Arg Pro Ser Leu Lys Thr Leu Gln Glu Lys Gly
            260                 265                 270         
Leu Ile Lys Asp Gln Ile Phe Gly Ser His Leu His Lys Val Cys Glu
        275                 280                 285             
Arg Glu Asn Ser Thr Val Pro Trp Phe Val Lys Gln Cys Ile Glu Ala
    290                 295                 300                 
Val Glu Lys Arg Gly Leu Asp Val Asp Ala Ile Tyr Arg Val Ser Gly
305                 310                 315                 320 
Asn Leu Gln Thr Ile Gln Lys Leu Arg Phe Ile Val Asn Gln Glu Glu
                325                 330                 335     
Lys Leu Asn Leu Asp Asp Ser Gln Trp Glu Asp Ile His Val Val Thr
            340                 345                 350         
Gly Ala Leu Lys Met Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro
        355                 360                 365             
Tyr Ser Phe Phe Glu Gln Phe Val Glu Ala Ile Lys Lys Gln Asp Asn
    370                 375                 380                 
Asn Thr Arg Ile Glu Ala Val Lys Ser Leu Val Gln Lys Leu Pro Pro
385                 390                 395                 400 
Pro Asn Arg Asp Thr Met Lys Val Leu Phe Gly His Leu Thr Lys Ile
                405                 410                 415     
Val Ala Lys Ala Ser Lys Asn Leu Met Ser Thr Gln Ser Leu Gly Ile
            420                 425                 430         
Val Phe Gly Pro Thr Leu Leu Arg Ala Glu Asn Glu Thr Gly Asn Met
        435                 440                 445             
Ala Ile His Met Val Tyr Gln Asn Gln Ile Ala Glu Leu Met Leu Ser
    450                 455                 460                 
Glu Tyr Ser Lys Ile Phe Gly Ser Glu Glu Asp
465                 470                 475 


<210> 7771
<211> 2024
<212> PRT
<213> Homo sapiens

<400> 7771
Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp
 1               5                  10                  15      
Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met
            20                  25                  30          
Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn
        35                  40                  45              
Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile
    50                  55                  60                  
Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro
65                  70                  75                  80  
His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu
                85                  90                  95      
Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu
            100                 105                 110         
Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala
        115                 120                 125             
Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu
    130                 135                 140                 
Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro
145                 150                 155                 160 
Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala
                165                 170                 175     
Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu
            180                 185                 190         
Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg
        195                 200                 205             
Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu
    210                 215                 220                 
Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr
225                 230                 235                 240 
His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe
                245                 250                 255     
Leu Lys Lys Ile Leu Ala Arg Asp Pro Gln Gln Glu Pro Met Glu Glu
            260                 265                 270         
Ile Glu Asn Leu Lys Lys Gln His Asp Leu Leu Lys Arg Met Leu Gln
        275                 280                 285             
Gln Gln Glu Gln Leu Arg Gly Ala Leu Gln Gly Arg Gln Ala Ala Leu
    290                 295                 300                 
Leu Ala Leu Gln His Lys Ala Asp Glu Ala Ile Ala Val Met Asp Asp
305                 310                 315                 320 
Ser Val Val Ala Glu Thr Ala Gly Ser Leu Ser Gly Val Ser Ile Thr
                325                 330                 335     
Ser Glu Leu Asn Glu Glu Leu Asn Asp Leu Ile Gln Arg Phe His Asn
            340                 345                 350         
Gln Leu Arg Asp Ser Gln Pro Pro Ala Val Pro Asp Asn Arg Arg Gln
        355                 360                 365             
Ala Glu Ser Leu Ser Leu Thr Arg Glu Val Ser Gln Ser Arg Lys Pro
    370                 375                 380                 
Ser Ala Ser Glu Arg Leu Pro Asp Glu Lys Val Glu Leu Phe Ser Lys
385                 390                 395                 400 
Met Arg Val Leu Gln Glu Lys Lys Gln Lys Met Asp Lys Leu Leu Gly
                405                 410                 415     
Glu Leu His Thr Leu Arg Asp Gln His Leu Asn Asn Ser Ser Ser Ser
            420                 425                 430         
Pro Gln Arg Ser Val Asp Gln Arg Ser Thr Ser Ala Pro Ser Ala Cys
        435                 440                 445             
Leu Gly Leu Ala Pro Val Val Asn Gly Glu Ser Asn Ser Leu Thr Ser
    450                 455                 460                 
Ser Val Pro Tyr Pro Thr Ala Ser Leu Val Ser Gln Asn Glu Ser Glu
465                 470                 475                 480 
Asn Glu Gly His Leu Asn Pro Ser Glu Lys Leu Gln Lys Leu Asn Glu
                485                 490                 495     
Val Arg Lys Arg Leu Asn Glu Leu Arg Glu Leu Val His Tyr Tyr Glu
            500                 505                 510         
Gln Thr Ser Asp Met Met Thr Asp Ala Val Asn Glu Asn Arg Lys Asp
        515                 520                 525             
Glu Glu Thr Glu Glu Ser Glu Tyr Asp Ser Glu His Glu Asn Ser Glu
    530                 535                 540                 
Pro Val Thr Asn Ile Arg Asn Pro Gln Val Ala Ser Thr Trp Asn Glu
545                 550                 555                 560 
Val Asn Ser His Ser Asn Ala Gln Cys Val Ser Asn Asn Arg Asp Gly
                565                 570                 575     
Arg Thr Val Asn Ser Asn Cys Glu Ile Asn Asn Arg Ser Ala Ala Asn
            580                 585                 590         
Ile Arg Ala Leu Asn Val Pro Pro Ser Leu Asp Cys Arg Tyr Asn Arg
        595                 600                 605             
Glu Gly Glu Gln Glu Ile His Val Ala Gln Gly Glu Asp Asp Glu Glu
    610                 615                 620                 
Glu Glu Glu Glu Ala Glu Glu Glu Gly Val Ser Gly Ala Ser Leu Ser
625                 630                 635                 640 
Ser His Arg Ser Ser Leu Val Asp Glu His Pro Glu Asp Ala Glu Phe
                645                 650                 655     
Glu Gln Lys Ile Asn Arg Leu Met Ala Ala Lys Gln Lys Leu Arg Gln
            660                 665                 670         
Leu Gln Asp Leu Val Ala Met Val Gln Asp Asp Asp Ala Ala Gln Gly
        675                 680                 685             
Val Ile Ser Ala Ser Ala Ser Asn Leu Asp Asp Phe Tyr Pro Ala Glu
    690                 695                 700                 
Glu Asp Thr Lys Gln Asn Ser Asn Asn Thr Arg Gly Asn Ala Asn Lys
705                 710                 715                 720 
Thr Gln Lys Asp Thr Gly Val Asn Glu Lys Ala Arg Glu Lys Phe Tyr
                725                 730                 735     
Glu Ala Lys Leu Gln Gln Gln Gln Arg Glu Leu Lys Gln Leu Gln Glu
            740                 745                 750         
Glu Arg Lys Lys Leu Ile Asp Ile His Glu Lys Ile Gln Ala Leu Gln
        755                 760                 765             
Thr Ala Cys Pro Asp Leu Gln Leu Ser Ala Ala Ser Val Gly Asn Cys
    770                 775                 780                 
Pro Thr Lys Lys Tyr Met Pro Ala Val Thr Ser Thr Pro Thr Val Asn
785                 790                 795                 800 
Gln His Glu Thr Ser Thr Ser Lys Ser Val Phe Glu Pro Glu Asp Ser
                805                 810                 815     
Ser Ile Val Asp Asn Glu Leu Trp Ser Glu Met Arg Arg His Glu Met
            820                 825                 830         
Leu Arg Glu Glu Leu Arg Gln Arg Arg Lys Gln Leu Glu Ala Leu Met
        835                 840                 845             
Ala Glu His Gln Arg Arg Gln Gly Leu Ala Glu Thr Ala Ser Pro Val
    850                 855                 860                 
Ala Val Ser Leu Arg Ser Asp Gly Ser Glu Asn Leu Cys Thr Pro Gln
865                 870                 875                 880 
Gln Ser Arg Thr Glu Lys Thr Met Ala Thr Trp Gly Gly Ser Thr Gln
                885                 890                 895     
Cys Ala Leu Asp Glu Glu Gly Asp Glu Asp Gly Tyr Leu Ser Glu Gly
            900                 905                 910         
Ile Val Arg Thr Asp Glu Glu Glu Glu Glu Glu Gln Asp Ala Ser Ser
        915                 920                 925             
Asn Asp Asn Phe Ser Val Cys Pro Ser Asn Ser Val Asn His Asn Ser
    930                 935                 940                 
Tyr Asn Arg Lys Glu Thr Lys Asn Thr Trp Lys Asn Asn Cys Pro Phe
945                 950                 955                 960 
Ser Ala Asp Glu Asn Tyr Arg Pro Leu Ala Lys Thr Arg Gln Gln Asn
                965                 970                 975     
Ile Ser Met Gln Arg Gln Glu Asn Leu Arg Trp Val Ser Glu Leu Ser
            980                 985                 990         
Tyr Val Glu Glu Lys Glu Gln Trp Gln Glu Gln Ile Gln Leu Lys Lys
        995                 1000                1005            
Gln Leu Asp Phe Ser Val Ser Ile Cys Gln Thr Leu Met Gln Asp Gln
    1010                1015                1020                
Gln Thr Leu Ser Cys Leu Leu Gln Thr Leu Leu Thr Gly Pro Tyr Ser
1025                1030                1035                1040
Val Met Pro Ser Asn Val Ala Ser Pro Gln Val His Phe Ile Met His
                1045                1050                1055    
Gln Leu Asn Gln Cys Tyr Thr Gln Leu Thr Trp Gln Gln Asn Asn Val
            1060                1065                1070        
Gln Arg Leu Lys Gln Met Leu Asn Glu Leu Met Arg Gln Arg Asn Gln
        1075                1080                1085            
His Pro Glu Lys Pro Gly Gly Lys Glu Arg Gly Ser Ser Ala Ser His
    1090                1095                1100                
Pro Pro Ser Pro Ser Leu Phe Cys Pro Phe Ser Phe Pro Thr Gln Pro
1105                1110                1115                1120
Val Asn Leu Phe Asn Ile Pro Gly Phe Thr Asn Phe Ser Ser Phe Ala
                1125                1130                1135    
Pro Gly Met Asn Phe Ser Pro Leu Phe Pro Ser Asn Phe Gly Asp Phe
            1140                1145                1150        
Ser Gln Asn Ile Ser Thr Pro Ser Glu Gln Gln Gln Pro Leu Ala Arg
        1155                1160                1165            
Ile Leu Ser Gly Lys Thr Glu Tyr Met Ala Phe Pro Lys Pro Phe Glu
    1170                1175                1180                
Ser Ser Ser Ser Ile Gly Ala Glu Lys Pro Arg Asn Lys Lys Leu Pro
1185                1190                1195                1200
Glu Glu Glu Val Glu Ser Ser Arg Thr Pro Trp Leu Tyr Glu Gln Glu
                1205                1210                1215    
Gly Glu Val Glu Lys Pro Phe Ile Lys Thr Gly Phe Ser Val Ser Val
            1220                1225                1230        
Glu Lys Ser Thr Ser Ser Asn Arg Lys Asn Gln Leu Asp Thr Asn Gly
        1235                1240                1245            
Arg Arg Arg Gln Phe Asp Glu Glu Ser Leu Glu Ser Phe Ser Ser Met
    1250                1255                1260                
Pro Asp Pro Val Asp Pro Thr Thr Val Thr Lys Thr Phe Lys Thr Arg
1265                1270                1275                1280
Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr Pro Lys
                1285                1290                1295    
Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln Leu Lys Ser Arg Val Lys
            1300                1305                1310        
Asn Ile Arg Tyr Glu Ser Ala Ser Met Ser Ser Thr Cys Glu Pro Cys
        1315                1320                1325            
Lys Ser Arg Asn Arg His Ser Ala Gln Thr Glu Glu Pro Leu Gln Ala
    1330                1335                1340                
Lys Val Phe Ser Arg Lys Asn His Glu Gln Leu Glu Lys Ile Ile Lys
1345                1350                1355                1360
Cys Asn Arg Ser Thr Glu Ile Ser Ser Glu Thr Gly Ser Asp Phe Ser
                1365                1370                1375    
Met Phe Glu Ala Leu Gln Asp Thr Ile Tyr Ser Glu Val Ala Thr Leu
            1380                1385                1390        
Ile Ser Gln Asn Glu Ser Arg Pro His Phe Leu Ile Glu Leu Phe His
        1395                1400                1405            
Glu Leu Gln Leu Leu Asn Thr Asp Tyr Leu Arg Gln Arg Ala Leu Tyr
    1410                1415                1420                
Ala Leu Gln Asp Ile Val Ser Arg His Ile Ser Glu Ser His Glu Lys
1425                1430                1435                1440
Gly Glu Asn Val Lys Ser Val Asn Ser Gly Thr Trp Ile Ala Ser Asn
                1445                1450                1455    
Ser Glu Leu Thr Pro Ser Glu Ser Leu Ala Thr Thr Asp Asp Glu Thr
            1460                1465                1470        
Phe Glu Lys Asn Phe Glu Arg Glu Thr His Lys Ile Ser Glu Gln Asn
        1475                1480                1485            
Asp Ala Asp Asn Ala Ser Val Leu Ser Val Ser Ser Asn Phe Glu Pro
    1490                1495                1500                
Phe Ala Thr Asp Asp Leu Gly Asn Thr Val Ile His Leu Asp Gln Ala
1505                1510                1515                1520
Leu Ala Arg Met Arg Glu Tyr Glu Arg Met Lys Thr Glu Ala Glu Ser
                1525                1530                1535    
Asn Ser Asn Met Arg Cys Thr Cys Arg Ile Ile Glu Asp Gly Asp Gly
            1540                1545                1550        
Ala Gly Ala Gly Thr Thr Val Asn Asn Leu Glu Glu Thr Pro Val Ile
        1555                1560                1565            
Glu Asn Arg Ser Ser Gln Gln Pro Val Ser Glu Val Ser Thr Ile Pro
    1570                1575                1580                
Cys Pro Arg Ile Asp Thr Gln Gln Leu Asp Arg Gln Ile Lys Ala Ile
1585                1590                1595                1600
Met Lys Glu Val Ile Pro Phe Leu Lys Glu His Met Asp Glu Val Cys
                1605                1610                1615    
Ser Ser Gln Leu Leu Thr Ser Val Arg Arg Met Val Leu Thr Leu Thr
            1620                1625                1630        
Gln Gln Asn Asp Glu Ser Lys Glu Phe Val Lys Phe Phe His Lys Gln
        1635                1640                1645            
Leu Gly Ser Ile Leu Gln Asp Ser Leu Ala Lys Phe Ala Gly Arg Lys
    1650                1655                1660                
Leu Lys Asp Cys Gly Glu Asp Leu Leu Val Glu Ile Ser Glu Val Leu
1665                1670                1675                1680
Phe Asn Glu Leu Ala Phe Phe Lys Leu Met Gln Asp Leu Asp Asn Asn
                1685                1690                1695    
Ser Ile Thr Val Lys Gln Arg Cys Lys Arg Lys Ile Glu Ala Thr Gly
            1700                1705                1710        
Val Ile Gln Ser Cys Ala Lys Glu Ala Lys Arg Ile Leu Glu Asp His
        1715                1720                1725            
Gly Ser Pro Ala Gly Glu Ile Asp Asp Glu Asp Lys Asp Lys Asp Glu
    1730                1735                1740                
Thr Glu Thr Val Lys Gln Thr Gln Thr Ser Glu Val Tyr Asp Gly Pro
1745                1750                1755                1760
Lys Asn Val Arg Ser Asp Ile Ser Asp Gln Glu Glu Asp Glu Glu Ser
                1765                1770                1775    
Glu Gly Cys Pro Val Ser Ile Asn Leu Ser Lys Ala Glu Thr Gln Ala
            1780                1785                1790        
Leu Thr Asn Tyr Gly Ser Gly Glu Asp Glu Asn Glu Asp Glu Glu Met
        1795                1800                1805            
Glu Glu Phe Glu Glu Gly Pro Val Asp Val Gln Thr Ser Leu Gln Ala
    1810                1815                1820                
Asn Thr Glu Ala Thr Glu Glu Asn Glu His Asp Glu Gln Val Leu Gln
1825                1830                1835                1840
Arg Asp Phe Lys Lys Thr Ala Glu Ser Lys Asn Val His Trp Asn Glu
                1845                1850                1855    
Lys Pro Leu Val Lys Met Thr Lys Asn Asn Cys Pro Val Lys Pro Ser
            1860                1865                1870        
Tyr Leu Asn Ile Leu Glu Asp Glu Gln Pro Leu Asn Ser Ala Ala His
        1875                1880                1885            
Lys Glu Ser Pro Pro Thr Val Asp Ser Thr Gln Gln Pro Asn Pro Leu
    1890                1895                1900                
Pro Leu Arg Leu Pro Glu Met Glu Pro Leu Val Pro Arg Val Lys Glu
1905                1910                1915                1920
Val Lys Ser Ala Gln Glu Thr Pro Glu Ser Ser Leu Ala Gly Ser Pro
                1925                1930                1935    
Asp Thr Glu Ser Pro Val Leu Val Asn Asp Tyr Glu Ala Glu Ser Gly
            1940                1945                1950        
Asn Ile Ser Gln Lys Ser Asp Glu Glu Asp Phe Val Lys Val Glu Asp
        1955                1960                1965            
Leu Pro Leu Lys Leu Thr Ile Tyr Ser Glu Ala Asp Leu Arg Lys Lys
    1970                1975                1980                
Met Val Glu Glu Glu Gln Lys Asn His Leu Ser Gly Glu Met Cys Glu
1985                1990                1995                2000
Met Gln Thr Glu Glu Leu Ala Gly Asn Ser Glu Thr Leu Lys Glu Pro
                2005                2010                2015    
Glu Thr Val Gly Ala Gln Ser Ile
            2020                


<210> 7772
<211> 530
<212> PRT
<213> Homo sapiens

<400> 7772
Met Ala Thr Gly Gly Gly Pro Phe Glu Asp Gly Met Asn Asp Gln Asp
 1               5                  10                  15      
Leu Pro Asn Trp Ser Asn Glu Asn Val Asp Asp Arg Leu Asn Asn Met
            20                  25                  30          
Asp Trp Gly Ala Gln Gln Lys Lys Ala Asn Arg Ser Ser Glu Lys Asn
        35                  40                  45              
Lys Lys Lys Phe Gly Val Glu Ser Asp Lys Arg Val Thr Asn Asp Ile
    50                  55                  60                  
Ser Pro Glu Ser Ser Pro Gly Val Gly Arg Arg Arg Thr Lys Thr Pro
65                  70                  75                  80  
His Thr Phe Pro His Ser Arg Tyr Met Ser Gln Met Ser Val Pro Glu
                85                  90                  95      
Gln Ala Glu Leu Glu Lys Leu Lys Gln Arg Ile Asn Phe Ser Asp Leu
            100                 105                 110         
Asp Gln Arg Ser Ile Gly Ser Asp Ser Gln Gly Arg Ala Thr Ala Ala
        115                 120                 125             
Asn Asn Lys Arg Gln Leu Ser Glu Asn Arg Lys Pro Phe Asn Phe Leu
    130                 135                 140                 
Pro Met Gln Ile Asn Thr Asn Lys Ser Lys Asp Ala Ser Thr Ser Pro
145                 150                 155                 160 
Pro Asn Arg Glu Thr Ile Gly Ser Ala Gln Cys Lys Glu Leu Phe Ala
                165                 170                 175     
Ser Ala Leu Ser Asn Asp Leu Leu Gln Asn Cys Gln Val Ser Glu Glu
            180                 185                 190         
Asp Gly Arg Gly Glu Pro Ala Met Glu Ser Ser Gln Ile Val Ser Arg
        195                 200                 205             
Leu Val Gln Ile Arg Asp Tyr Ile Thr Lys Ala Ser Ser Met Arg Glu
    210                 215                 220                 
Asp Leu Val Glu Lys Asn Glu Arg Ser Ala Asn Val Glu Arg Leu Thr
225                 230                 235                 240 
His Leu Ile Asp His Leu Lys Glu Gln Glu Lys Ser Tyr Met Lys Phe
                245                 250                 255     
Leu Lys Lys Ile Leu Ala Arg Glu Asn Glu Glu Glu Asp Val Arg Thr
            260                 265                 270         
Ile Asp Ser Ala Val Gly Ser Gly Ser Val Ala Glu Ser Thr Ser Leu
        275                 280                 285             
Asn Ile Asp Val Gln Ser Glu Ala Ser Asp Thr Thr Ala Arg Asp Pro
    290                 295                 300                 
Gln Gln Glu Pro Met Glu Glu Ile Glu Asn Leu Lys Lys Gln His Asp
305                 310                 315                 320 
Leu Leu Lys Arg Met Leu Gln Gln Gln Glu Gln Leu Arg Ala Leu Gln
                325                 330                 335     
Gly Arg Gln Ala Ala Leu Leu Ala Leu Gln His Lys Ala Glu Gln Ala
            340                 345                 350         
Ile Ala Val Met Asp Asp Ser Val Val Ala Glu Thr Ala Gly Ser Leu
        355                 360                 365             
Ser Gly Val Ser Ile Thr Ser Glu Leu Asn Glu Glu Leu Asn Asp Leu
    370                 375                 380                 
Ile Gln Arg Phe His Asn Gln Leu Arg Asp Ser Gln Pro Pro Ala Val
385                 390                 395                 400 
Pro Asp Asn Arg Arg Gln Ala Glu Ser Leu Ser Leu Thr Arg Glu Val
                405                 410                 415     
Ser Gln Ser Arg Lys Pro Ser Ala Ser Glu Arg Leu Pro Asp Glu Lys
            420                 425                 430         
Val Glu Leu Phe Ser Lys Met Arg Val Leu Gln Glu Lys Lys Gln Lys
        435                 440                 445             
Met Asp Lys Leu Leu Gly Glu Leu His Thr Leu Arg Asp Gln His Leu
    450                 455                 460                 
Asn Asn Ser Ser Ser Ser Pro Gln Arg Ser Val Asp Gln Arg Ser Thr
465                 470                 475                 480 
Ser Ala Pro Ser Ala Ser Val Gly Leu Ala Pro Val Val Asn Gly Glu
                485                 490                 495     
Ser Asn Ser Leu Thr Ser Ser Val Pro Tyr Pro Thr Ala Ser Leu Val
            500                 505                 510         
Ser Gln Asn Glu Ser Glu Asn Glu Gly His Leu Asn Pro Ser Glu Lys
        515                 520                 525             
Leu Gln
    530 


<210> 7773
<211> 305
<212> PRT
<213> Homo sapiens

<400> 7773
Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala
 1               5                  10                  15      
Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu
            20                  25                  30          
Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr
        35                  40                  45              
Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp
    50                  55                  60                  
Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala
65                  70                  75                  80  
Glu Asn Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln
                85                  90                  95      
Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp
            100                 105                 110         
Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu
        115                 120                 125             
Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln
    130                 135                 140                 
Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys
145                 150                 155                 160 
Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser
                165                 170                 175     
Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn
            180                 185                 190         
Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn
        195                 200                 205             
Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln
    210                 215                 220                 
Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe
225                 230                 235                 240 
Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro
                245                 250                 255     
Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu
            260                 265                 270         
Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln
        275                 280                 285             
Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp
    290                 295                 300                 
Val
305 


<210> 7774
<211> 232
<212> PRT
<213> Homo sapiens

<400> 7774
Met Asp Leu Pro Ile Gln Asp Ser His Asp Ser Ser Thr Ser Pro Lys
 1               5                  10                  15      
Gly Lys Gln Pro Thr Thr Ala Glu Lys Ser Ala Thr Lys Lys Glu Asp
            20                  25                  30          
Lys Val Pro Val Lys Lys Gln Lys Thr Arg Thr Val Phe Ser Ser Thr
        35                  40                  45              
Gln Leu Cys Val Leu Asn Asp Arg Phe Gln Arg Gln Lys Tyr Leu Ser
    50                  55                  60                  
Leu Gln Gln Met Gln Glu Leu Ser Asn Ile Leu Asn Leu Ser Tyr Lys
65                  70                  75                  80  
Gln Val Lys Thr Trp Phe Gln Asn Gln Arg Met Lys Ser Lys Arg Trp
                85                  90                  95      
Gln Lys Asn Asn Trp Leu Lys Asn Ser Asn Gly Val Thr Gln Gly Cys
            100                 105                 110         
Leu Val Asn Pro Thr Gly Asn Leu Pro Met Trp Ser Asn Gln Thr Trp
        115                 120                 125             
Asn Asn Ser Thr Trp Ser Asn Gln Thr Gln Asn Ile Gln Ser Trp Ser
    130                 135                 140                 
Asn His Ser Trp Asn Thr Gln Thr Trp Cys Thr Gln Ser Trp Asn Asn
145                 150                 155                 160 
Gln Ala Trp Asn Ser Pro Phe Tyr Asn Cys Gly Glu Glu Ser Leu Gln
                165                 170                 175     
Ser Cys Met Gln Phe Gln Pro Asn Ser Pro Ala Ser Asp Leu Gln Ala
            180                 185                 190         
Ala Leu Glu Ala Ala Gly Glu Gly Leu Asn Val Ile Gln Gln Thr Thr
        195                 200                 205             
Arg Tyr Phe Asn Thr Pro Gln Thr Met Asp Leu Phe Leu Asn Tyr Ser
    210                 215                 220                 
Met Asn Met Gln Pro Glu Asp Val
225                 230         


<210> 7775
<211> 305
<212> PRT
<213> Homo sapiens

<400> 7775
Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Glu
 1               5                  10                  15      
Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu
            20                  25                  30          
Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr
        35                  40                  45              
Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp
    50                  55                  60                  
Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala
65                  70                  75                  80  
Glu Asn Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln
                85                  90                  95      
Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp
            100                 105                 110         
Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu
        115                 120                 125             
Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln
    130                 135                 140                 
Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys
145                 150                 155                 160 
Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser
                165                 170                 175     
Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn
            180                 185                 190         
Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn
        195                 200                 205             
Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln
    210                 215                 220                 
Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe
225                 230                 235                 240 
Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met His Phe Gln Pro
                245                 250                 255     
Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu
            260                 265                 270         
Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln
        275                 280                 285             
Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp
    290                 295                 300                 
Val
305 


<210> 7776
<211> 1127
<212> PRT
<213> Homo sapiens

<400> 7776
Met Asn Leu Leu Ile Val Lys Ala Val Gln Met His Tyr Phe Phe Leu
 1               5                  10                  15      
Leu Leu Glu Glu Val Thr Ser Arg Glu Val Ala Gln Ile Ser Gly Lys
            20                  25                  30          
Cys Asn Ile Leu Glu Phe Ser Val Leu Lys Asp Arg Met Ser Arg Val
        35                  40                  45              
Cys Ile Val Val Leu Glu Glu Val Glu Asp Glu Ser Pro Ala Phe Ile
    50                  55                  60                  
Ser Lys Leu Pro Gln Glu Asn Lys Ser Leu His Ser Pro Pro Ser Gly
65                  70                  75                  80  
Asn Val Leu Pro Ser Leu Val Gln Ala Ile Phe Asn Gly Asp Pro Asp
                85                  90                  95      
Glu Val Arg Ala Leu Ile Phe Lys Lys Glu Asp Val Asn Phe Gln Asp
            100                 105                 110         
Asn Glu Lys Arg Thr Pro Leu His Ala Ala Ala Tyr Leu Gly Asp Ala
        115                 120                 125             
Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly Ala Arg Val Asn Ala Lys
    130                 135                 140                 
Asp Ser Lys Trp Leu Thr Pro Leu His Arg Ala Val Ala Ser Cys Ser
145                 150                 155                 160 
Glu Glu Ala Val Gln Val Leu Leu Lys His Ser Ala Asp Val Asn Ala
                165                 170                 175     
Arg Asp Lys Asn Trp Gln Thr Pro Leu His Ile Ala Ala Ala Asn Lys
            180                 185                 190         
Ala Val Lys Cys Ala Glu Ala Leu Val Pro Leu Leu Ser Asn Val Asn
        195                 200                 205             
Val Ser Asp Arg Ala Gly Arg Thr Ala Leu His His Ala Ala Phe Ser
    210                 215                 220                 
Gly His Gly Glu Met Val Lys Leu Leu Leu Ser Arg Gly Ala Asn Ile
225                 230                 235                 240 
Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala Ile His Trp Ala Ala Tyr
                245                 250                 255     
Met Gly His Ile Glu Val Val Lys Leu Leu Val Ser His Gly Ala Glu
            260                 265                 270         
Val Thr Cys Lys Asp Lys Lys Ser Tyr Thr Pro Leu His Ala Ala Ala
        275                 280                 285             
Ser Ser Gly Met Ile Ser Val Val Lys Tyr Leu Leu Asp Leu Gly Val
    290                 295                 300                 
Asp Met Asn Glu Pro Asn Ala Tyr Gly Asn Thr Pro Leu His Val Ala
305                 310                 315                 320 
Cys Tyr Asn Gly Gln Asp Val Val Val Asn Glu Leu Ile Asp Cys Gly
                325                 330                 335     
Ala Ile Val Asn Gln Lys Asn Glu Lys Gly Phe Thr Pro Leu His Phe
            340                 345                 350         
Ala Ala Ala Ser Thr His Gly Ala Leu Cys Leu Glu Leu Leu Val Gly
        355                 360                 365             
Asn Gly Ala Asp Val Asn Met Lys Ser Lys Asp Gly Lys Thr Pro Leu
    370                 375                 380                 
His Met Thr Ala Leu His Gly Arg Phe Ser Arg Ser Gln Thr Ile Ile
385                 390                 395                 400 
Gln Ser Gly Ala Val Ile Asp Cys Glu Asp Lys Asn Gly Asn Thr Pro
                405                 410                 415     
Leu His Ile Ala Ala Arg Tyr Gly His Glu Leu Leu Ile Asn Thr Leu
            420                 425                 430         
Ile Thr Ser Gly Ala Asp Thr Ala Lys Arg Gly Ile His Gly Met Phe
        435                 440                 445             
Pro Leu His Leu Ala Ala Leu Ser Gly Phe Ser Asp Cys Cys Arg Lys
    450                 455                 460                 
Leu Leu Ser Ser Gly Phe Asp Ile Asp Thr Pro Asp Asp Phe Gly Arg
465                 470                 475                 480 
Thr Cys Leu His Ala Ala Ala Ala Gly Gly Asn Leu Glu Cys Leu Asn
                485                 490                 495     
Leu Leu Leu Asn Thr Gly Ala Asp Phe Asn Lys Lys Asp Lys Phe Gly
            500                 505                 510         
Arg Ser Pro Leu His Tyr Ala Ala Ala Asn Cys Asn Tyr Gln Cys Leu
        515                 520                 525             
Phe Ala Leu Val Gly Ser Gly Ala Ser Val Asn Asp Leu Asp Glu Arg
    530                 535                 540                 
Gly Cys Thr Pro Leu His Tyr Ala Ala Thr Ser Asp Thr Asp Gly Lys
545                 550                 555                 560 
Cys Leu Glu Tyr Leu Leu Arg Asn Asp Ala Asn Pro Gly Ile Arg Asp
                565                 570                 575     
Lys Gln Gly Tyr Asn Ala Val His Tyr Ser Ala Ala Tyr Gly His Arg
            580                 585                 590         
Leu Cys Leu Gln Leu Ile Ala Ser Glu Thr Pro Leu Asp Val Leu Met
        595                 600                 605             
Glu Thr Ser Gly Thr Asp Met Leu Ser Asp Ser Asp Asn Arg Ala Thr
    610                 615                 620                 
Ile Ser Pro Leu His Leu Ala Ala Tyr His Gly His His Gln Ala Leu
625                 630                 635                 640 
Glu Val Leu Val Gln Ser Leu Leu Asp Leu Asp Val Arg Asn Ser Ser
                645                 650                 655     
Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe Lys Gly His Val Glu Cys
            660                 665                 670         
Val Asp Val Leu Ile Asn Gln Gly Ala Ser Ile Leu Val Lys Asp Tyr
        675                 680                 685             
Ile Leu Lys Arg Thr Pro Ile His Ala Ala Ala Thr Asn Gly His Ser
    690                 695                 700                 
Glu Cys Leu Arg Leu Leu Ile Gly Asn Ala Glu Pro Gln Asn Ala Val
705                 710                 715                 720 
Asp Ile Gln Asp Gly Asn Gly Gln Thr Pro Leu Met Leu Ser Val Leu
                725                 730                 735     
Asn Gly His Thr Asp Cys Val Tyr Ser Leu Leu Asn Lys Gly Ala Asn
            740                 745                 750         
Val Asp Ala Lys Asp Lys Trp Gly Arg Thr Ala Leu His Arg Gly Ala
        755                 760                 765             
Val Thr Gly His Glu Glu Cys Val Asp Ala Leu Leu Gln His Gly Ala
    770                 775                 780                 
Lys Cys Leu Leu Arg Asp Ser Arg Gly Arg Thr Pro Ile His Leu Ser
785                 790                 795                 800 
Ala Ala Cys Gly His Ile Gly Val Leu Gly Ala Leu Leu Gln Ser Ala
                805                 810                 815     
Ala Ser Met Asp Ala Asn Pro Ala Thr Ala Asp Asn His Gly Tyr Thr
            820                 825                 830         
Ala Leu His Trp Ala Cys Tyr Asn Gly His Glu Thr Cys Val Glu Leu
        835                 840                 845             
Leu Leu Glu Gln Glu Val Phe Gln Lys Thr Glu Gly Asn Ala Phe Ser
    850                 855                 860                 
Pro Leu His Cys Ala Val Ile Asn Asp Asn Glu Gly Ala Ala Glu Met
865                 870                 875                 880 
Leu Ile Asp Thr Leu Gly Ala Ser Ile Val Asn Ala Thr Asp Ser Lys
                885                 890                 895     
Gly Arg Thr Pro Leu His Ala Ala Ala Phe Thr Asp His Val Glu Cys
            900                 905                 910         
Leu Gln Leu Leu Leu Ser His Asn Ala Gln Val Asn Ser Val Asp Ser
        915                 920                 925             
Thr Gly Lys Thr Pro Leu Met Met Ala Ala Glu Asn Gly Gln Thr Asn
    930                 935                 940                 
Thr Val Glu Met Leu Val Ser Ser Ala Ser Ala Glu Leu Thr Leu Gln
945                 950                 955                 960 
Asp Asn Ser Lys Asn Thr Ala Leu His Leu Ala Cys Ser Lys Gly His
                965                 970                 975     
Glu Thr Ser Ala Leu Leu Ile Leu Glu Lys Ile Thr Asp Arg Asn Leu
            980                 985                 990         
Ile Asn Ala Thr Asn Ala Ala Leu Gln Thr Pro Leu His Val Ala Ala
        995                 1000                1005            
Arg Asn Gly Leu Thr Met Val Val Gln Glu Leu Leu Gly Lys Gly Ala
    1010                1015                1020                
Ser Val Leu Ala Val Asp Glu Asn Gly Tyr Thr Pro Ala Leu Ala Cys
1025                1030                1035                1040
Ala Pro Asn Lys Asp Val Ala Asp Cys Leu Ala Leu Ile Leu Ala Thr
                1045                1050                1055    
Met Met Pro Val Ser Ser Ser Ser Pro Leu Ser Ser Leu Thr Phe Asn
            1060                1065                1070        
Ala Ile Asn Arg Tyr Thr Asn Thr Ser Lys Thr Val Ser Phe Glu Ala
        1075                1080                1085            
Leu Pro Ile Met Arg Asn Glu Pro Ser Ser Tyr Cys Ser Phe Asn Asn
    1090                1095                1100                
Ile Gly Gly Glu Gln Glu Tyr Leu Tyr Thr Asp Val Asp Glu Leu Asn
1105                1110                1115                1120
Asp Ser Asp Ser Glu Thr Tyr
                1125        


<210> 7777
<211> 394
<212> PRT
<213> Homo sapiens

<400> 7777
Met Pro Ser Asn Ser Ser Ala Ser Ile Ser Lys Leu Arg Glu Ser Leu
 1               5                  10                  15      
Thr Pro Asp Gly Ser Lys Trp Ser Thr Ser Leu Met Gln Thr Leu Gly
            20                  25                  30          
Asn His Ser Arg Gly Glu Gln Asp Ser Ser Leu Asp Met Lys Asp Phe
        35                  40                  45              
Arg Pro Leu Arg Lys Trp Ser Ser Leu Ser Lys Leu Thr Ala Pro Asp
    50                  55                  60                  
Asn Cys Gly Gln Gly Gly Thr Val Cys Arg Glu Glu Ser Arg Asn Gly
65                  70                  75                  80  
Leu Glu Lys Ile Gly Lys Ala Lys Ala Leu Thr Ser Gln Leu Arg Thr
                85                  90                  95      
Ile Gly Pro Ser Cys Leu His Asp Ser Met Glu Met Leu Arg Leu Glu
            100                 105                 110         
Asp Lys Glu Ile Asn Lys Lys Arg Ser Ser Thr Leu Asp Cys Lys Tyr
        115                 120                 125             
Lys Phe Glu Ser Cys Ser Lys Glu Asp Phe Arg Ala Ser Ser Ser Thr
    130                 135                 140                 
Leu Arg Arg Gln Thr Val Asp Met Thr Tyr Ser Ala Leu Pro Glu Ser
145                 150                 155                 160 
Lys Pro Ile Met Thr Ser Ser Glu Ala Phe Glu Pro Pro Lys Tyr Leu
                165                 170                 175     
Met Leu Gly Gln Gln Ala Val Gly Gly Val Pro Ile Gln Pro Ser Val
            180                 185                 190         
Arg Thr Gln Met Trp Leu Thr Glu Gln Leu Arg Thr Asn Pro Leu Glu
        195                 200                 205             
Gly Arg Asn Thr Glu Asp Ser Tyr Ser Leu Ala Pro Trp Gln Gln Gln
    210                 215                 220                 
Gln Ile Glu Asp Phe Arg Gln Gly Ser Glu Thr Pro Met Gln Val Leu
225                 230                 235                 240 
Thr Gly Ser Ser Arg Gln Ser Tyr Ser Pro Gly Tyr Gln Asp Phe Ser
                245                 250                 255     
Lys Trp Glu Ser Met Leu Lys Ile Lys Glu Gly Leu Leu Arg Gln Lys
            260                 265                 270         
Glu Ile Val Ile Asp Arg Gln Lys Gln Gln Ile Thr His Leu His Glu
        275                 280                 285             
Arg Ile Arg Asp Asn Glu Leu Arg Ala Gln His Ala Met Leu Gly His
    290                 295                 300                 
Tyr Val Asn Cys Glu Asp Ser Tyr Val Ala Ser Leu Gln Pro Gln Tyr
305                 310                 315                 320 
Glu Asn Thr Ser Leu Gln Thr Pro Phe Ser Glu Glu Ser Val Ser His
                325                 330                 335     
Ser Gln Gln Gly Glu Phe Glu Gln Lys Leu Ala Ser Thr Glu Lys Glu
            340                 345                 350         
Val Leu Gln Leu Asn Glu Phe Leu Lys Gln Arg Leu Ser Leu Phe Ser
        355                 360                 365             
Glu Glu Lys Lys Lys Leu Glu Glu Lys Val Gly Phe Ser Asn Lys Val
    370                 375                 380                 
Glu Leu Gly Gln Gln His Phe Leu Ser Ile
385                 390                 


<210> 7778
<211> 1385
<212> PRT
<213> Homo sapiens

<400> 7778
Glu Gln Leu Arg Arg His Gln Gly Lys Asn Leu Ala Ser Glu Asp Pro
 1               5                  10                  15      
Lys Lys Lys Arg Ala Gln Lys Pro Ser His Met Arg Arg Asn Ile Arg
            20                  25                  30          
Lys Leu Leu Arg Glu Asp Gln Leu Gln Pro Val Thr Lys Ala Ala Gln
        35                  40                  45              
Gln Glu Glu Leu Glu Arg Arg Lys Arg Leu Glu Gln Gln Arg Lys Asp
    50                  55                  60                  
Tyr Ala Ala Pro Ile Pro Thr Val Pro Leu Glu Phe Leu Pro Glu Glu
65                  70                  75                  80  
Ile Ala Leu Arg Ala Ser Asp Gly Pro Gln Leu Pro Pro Arg Val Leu
                85                  90                  95      
Ala Gln Glu Val Ile Cys Leu Asp Ser Ser Ser Gly Ser Glu Asp Glu
            100                 105                 110         
Lys Ser Ser Arg Asp Glu Val Ile Glu Leu Ser Ser Gly Glu Glu Asp
        115                 120                 125             
Thr Leu His Ile Val Asp Ser Ser Glu Ser Val Ser Glu Asp Asp Glu
    130                 135                 140                 
Glu Glu Glu Lys Gly Gly Thr His Val Asn Asp Val Leu Asn Gln Arg
145                 150                 155                 160 
Asp Ala Leu Gly Arg Val Leu Val Asn Leu Asn His Pro Pro Glu Glu
                165                 170                 175     
Glu Asn Val Phe Leu Ala Pro Gln Leu Ala Arg Ala Val Lys Pro His
            180                 185                 190         
Gln Ile Gly Gly Ile Arg Phe Leu Tyr Asp Asn Leu Val Glu Ser Leu
        195                 200                 205             
Glu Arg Phe Lys Thr Ser Ser Gly Phe Gly Cys Ile Leu Ala His Ser
    210                 215                 220                 
Met Gly Leu Gly Lys Thr Leu Gln Val Ile Ser Phe Ile Asp Val Leu
225                 230                 235                 240 
Phe Arg His Thr Pro Val Lys Thr Val Leu Ala Ile Val Pro Val Asn
                245                 250                 255     
Thr Leu Gln Asn Trp Leu Ala Glu Phe Asn Met Trp Leu Pro Pro Pro
            260                 265                 270         
Glu Ala Leu Pro Ala Asp Asn Lys Pro Glu Glu Val Gln Pro Arg Phe
        275                 280                 285             
Phe Lys Val His Ile Leu Asn Asp Glu His Lys Thr Met Ala Ser Arg
    290                 295                 300                 
Ala Lys Val Met Ala Asp Trp Val Ser Glu Gly Gly Val Leu Leu Met
305                 310                 315                 320 
Gly Tyr Glu Met Tyr Arg Leu Leu Thr Leu Lys Lys Ser Phe Ala Thr
                325                 330                 335     
Gly Arg Pro Lys Lys Thr Lys Lys Arg Ser His Pro Val Ile Ile Asp
            340                 345                 350         
Leu Asp Glu Glu Asp Arg Gln Gln Glu Phe Arg Arg Glu Phe Glu Lys
        355                 360                 365             
Ala Leu Cys Arg Pro Gly Pro Asp Val Val Ile Cys Asp Glu Gly His
    370                 375                 380                 
Arg Ile Lys Asn Cys Gln Ala Ser Thr Ser Gln Ala Leu Lys Asn Ile
385                 390                 395                 400 
Arg Ser Arg Arg Arg Val Val Leu Thr Gly Tyr Pro Leu Gln Asn Asn
                405                 410                 415     
Leu Ile Glu Tyr Trp Cys Met Val Asp Phe Val Arg Pro Asp Phe Leu
            420                 425                 430         
Gly Thr Arg Gln Glu Phe Ser Asn Met Phe Glu Arg Pro Ile Leu Asn
        435                 440                 445             
Gly Gln Cys Ile Asp Ser Thr Pro Gln Asp Val Arg Leu Met Arg Tyr
    450                 455                 460                 
Arg Ser His Val Leu His Ser Leu Leu Glu Gly Phe Val Gln Arg Arg
465                 470                 475                 480 
Gly His Thr Val Leu Lys Ile His Leu Pro Ala Lys Glu Glu Asn Val
                485                 490                 495     
Ile Leu Val Arg Leu Ser Lys Ile Gln Arg Asp Leu Tyr Thr Gln Phe
            500                 505                 510         
Met Asp Arg Phe Arg Asp Cys Gly Ser Ser Gly Trp Leu Gly Leu Asn
        515                 520                 525             
Pro Leu Lys Ala Phe Cys Val Cys Cys Lys Ile Trp Asn His Pro Asp
    530                 535                 540                 
Val Leu Tyr Glu Ala Leu Gln Lys Glu Ser Leu Ala Asn Glu Gln Asp
545                 550                 555                 560 
Leu Asp Val Glu Glu Leu Gly Ser Ala Gly Thr Ser Ala Arg Cys Pro
                565                 570                 575     
Pro Gln Gly Thr Lys Gly Lys Gly Glu Asp Ser Thr Leu Ala Ser Ser
            580                 585                 590         
Met Gly Glu Ala Thr Asn Ser Lys Phe Leu Gln Gly Val Gly Phe Asn
        595                 600                 605             
Pro Phe Gln Glu Arg Gly Asn Asn Ile Val Thr Tyr Glu Trp Ala Lys
    610                 615                 620                 
Asp Leu Leu Thr Asn Tyr Gln Thr Gly Val Leu Glu Asn Ser Pro Lys
625                 630                 635                 640 
Met Val Leu Leu Phe His Leu Ile Glu Glu Ser Val Lys Leu Gly Asp
                645                 650                 655     
Lys Ile Leu Val Phe Ser Gln Ser Leu Ser Thr Leu Ala Leu Ile Glu
            660                 665                 670         
Glu Phe Leu Gly Lys Arg Glu Val Pro Cys Pro Pro Gly Thr Glu Gly
        675                 680                 685             
Gln Gly Ala Gln Lys Trp Val Arg Asn Ile Ser Tyr Phe Arg Leu Asp
    690                 695                 700                 
Gly Ser Thr Pro Ala Phe Glu Arg Glu Arg Leu Ile Asn Gln Phe Asn
705                 710                 715                 720 
Asp Pro Ser Asn Leu Thr Thr Trp Leu Phe Leu Leu Ser Thr Arg Ala
                725                 730                 735     
Gly Cys Leu Gly Val Asn Leu Ile Gly Ala Asn Arg Val Val Val Phe
            740                 745                 750         
Asp Ala Ser Trp Asn Pro Cys His Asp Ala Gln Ala Val Cys Arg Val
        755                 760                 765             
Tyr Arg Tyr Gly Gln Lys Lys Pro Cys Tyr Ile Tyr Arg Leu Val Ala
    770                 775                 780                 
Asp Tyr Thr Leu Glu Lys Lys Ile Tyr Asp Arg Gln Ile Ser Lys Gln
785                 790                 795                 800 
Gly Met Ser Asp Arg Val Val Asp Asp Leu Asn Pro Met Leu Asn Phe
                805                 810                 815     
Thr Arg Lys Glu Val Glu Asn Leu Leu His Phe Val Glu Lys Glu Pro
            820                 825                 830         
Ala Pro Gln Val Ser Leu Asn Val Lys Gly Ile Lys Glu Ser Val Leu
        835                 840                 845             
Gln Leu Ala Cys Leu Lys Tyr Pro His Leu Ile Thr Lys Glu Pro Phe
    850                 855                 860                 
Glu His Glu Ser Leu Leu Leu Asn Arg Lys Asp His Lys Leu Thr Lys
865                 870                 875                 880 
Ala Glu Lys Lys Ala Ala Lys Lys Ser Tyr Glu Glu Asp Lys Arg Thr
                885                 890                 895     
Ser Val Pro Tyr Thr Arg Pro Ser Tyr Ala Gln Tyr Tyr Pro Ala Ser
            900                 905                 910         
Asp Gln Ser Leu Thr Ser Ile Pro Ala Phe Ser Gln Arg Asn Trp Gln
        915                 920                 925             
Pro Thr Leu Lys Gly Asp Glu Lys Pro Val Ala Ser Val Arg Pro Val
    930                 935                 940                 
Gln Ser Thr Pro Ile Pro Met Met Pro Arg His Val Pro Leu Gly Gly
945                 950                 955                 960 
Ser Val Ser Ser Ala Ser Ser Thr Asn Pro Ser Met Asn Phe Pro Ile
                965                 970                 975     
Asn Tyr Leu Gln Arg Ala Gly Val Leu Val Gln Lys Val Val Thr Thr
            980                 985                 990         
Thr Asp Ile Val Ile Pro Gly Leu Asn Ser Ser Thr Asp Val Gln Ala
        995                 1000                1005            
Arg Ile Asn Ala Gly Glu Ser Ile His Ile Ile Arg Gly Thr Lys Gly
    1010                1015                1020                
Thr Tyr Ile Arg Thr Ser Asp Gly Arg Ile Phe Ala Val Arg Ala Thr
1025                1030                1035                1040
Gly Lys Pro Lys Val Pro Glu Asp Gly Arg Met Ala Ala Ser Gly Ser
                1045                1050                1055    
Gln Gly Pro Ser Cys Glu Ser Thr Ser Asn Gly Arg His Ser Ala Ser
            1060                1065                1070        
Ser Pro Lys Ala Pro Asp Pro Glu Gly Leu Ala Arg Pro Val Ser Pro
        1075                1080                1085            
Asp Ser Pro Glu Ile Ile Ser Glu Leu Gln Gln Tyr Ala Asp Val Ala
    1090                1095                1100                
Ala Ala Arg Glu Ser Arg Gln Ser Ser Pro Ser Thr Asn Ala Ala Leu
1105                1110                1115                1120
Pro Gly Pro Pro Ala Gln Leu Met Asp Ser Ser Ala Val Pro Gly Thr
                1125                1130                1135    
Ala Leu Gly Thr Glu Pro Arg Leu Gly Gly His Cys Leu Asn Ser Ser
            1140                1145                1150        
Leu Leu Val Thr Gly Gln Pro Cys Gly Asp Arg His Pro Val Leu Asp
        1155                1160                1165            
Leu Arg Gly His Lys Arg Lys Leu Ala Thr Pro Pro Ala Ala Gln Glu
    1170                1175                1180                
Ser Ser Arg Arg Arg Ser Arg Lys Gly His Leu Pro Ala Pro Val Gln
1185                1190                1195                1200
Pro Tyr Glu His Gly Tyr Pro Val Ser Gly Gly Phe Ala Met Pro Pro
                1205                1210                1215    
Val Ser Leu Asn His Asn Leu Thr Thr Pro Phe Thr Ser Gln Ala Gly
            1220                1225                1230        
Glu Asn Ser Leu Phe Met Gly Ser Thr Pro Ser Tyr Tyr Gln Leu Ser
        1235                1240                1245            
Asn Leu Leu Ala Asp Ala Arg Leu Val Phe Pro Val Thr Thr Asp Pro
    1250                1255                1260                
Leu Val Pro Ala Gly Pro Val Ser Ser Ser Ser Thr Ala Thr Ser Val
1265                1270                1275                1280
Thr Ala Ser Asn Pro Ser Phe Met Leu Asn Pro Ser Val Pro Gly Ile
                1285                1290                1295    
Leu Pro Ser Tyr Ser Leu Pro Phe Ser Gln Pro Leu Leu Ser Glu Pro
            1300                1305                1310        
Arg Met Phe Ala Pro Phe Pro Ser Pro Val Leu Pro Ser Asn Leu Ser
        1315                1320                1325            
Arg Gly Met Ser Ile Tyr Pro Gly Tyr Met Ser Pro His Ala Gly Tyr
    1330                1335                1340                
Pro Ala Gly Gly Leu Leu Arg Ser Gln Val Pro Pro Phe Asp Ser His
1345                1350                1355                1360
Glu Val Ala Glu Val Gly Phe Ser Ser Asn Asp Asp Glu Asp Lys Asp
                1365                1370                1375    
Asp Asp Val Ile Glu Val Thr Gly Lys
            1380                1385


<210> 7779
<211> 1084
<212> PRT
<213> Homo sapiens

<400> 7779
Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro
 1               5                  10                  15      
Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val
            20                  25                  30          
Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro
        35                  40                  45              
Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro
    50                  55                  60                  
Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln
65                  70                  75                  80  
Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln
                85                  90                  95      
His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile
            100                 105                 110         
Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu
        115                 120                 125             
Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu
    130                 135                 140                 
Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys
145                 150                 155                 160 
Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln
                165                 170                 175     
Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn
            180                 185                 190         
His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His
        195                 200                 205             
Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser
    210                 215                 220                 
Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro
225                 230                 235                 240 
Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu
                245                 250                 255     
Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys
            260                 265                 270         
Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr
        275                 280                 285             
Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn
    290                 295                 300                 
Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val
305                 310                 315                 320 
Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg
                325                 330                 335     
Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro
            340                 345                 350         
Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala
        355                 360                 365             
Gly Gln Gln Asp Thr Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg
    370                 375                 380                 
Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser
385                 390                 395                 400 
Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His
                405                 410                 415     
Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Gly
            420                 425                 430         
Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg
        435                 440                 445             
Val Ser Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg
    450                 455                 460                 
Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu
465                 470                 475                 480 
Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln
                485                 490                 495     
Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser
            500                 505                 510         
Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu
        515                 520                 525             
Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu
    530                 535                 540                 
Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln
545                 550                 555                 560 
Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val
                565                 570                 575     
Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln
            580                 585                 590         
Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr
        595                 600                 605             
Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His
    610                 615                 620                 
Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro
625                 630                 635                 640 
Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu
                645                 650                 655     
Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser
            660                 665                 670         
Ser Ser His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg
        675                 680                 685             
Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg
    690                 695                 700                 
Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr
705                 710                 715                 720 
Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys
                725                 730                 735     
Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly
            740                 745                 750         
Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala
        755                 760                 765             
Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys
    770                 775                 780                 
Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro
785                 790                 795                 800 
Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn
                805                 810                 815     
Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser
            820                 825                 830         
Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln
        835                 840                 845             
Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg
    850                 855                 860                 
Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val
865                 870                 875                 880 
Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly
                885                 890                 895     
Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg
            900                 905                 910         
Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu
        915                 920                 925             
Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly
    930                 935                 940                 
Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu
945                 950                 955                 960 
Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His
                965                 970                 975     
Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu
            980                 985                 990         
Leu Gly Asn Glu Leu Asp Pro Leu Pro Glu Lys Val Leu Gln Gln Arg
        995                 1000                1005            
Pro Asn Ala Asn Ala Val Arg Ser Met Glu Lys Val Met Glu Ile His
    1010                1015                1020                
Ser Lys Tyr Trp Arg Cys Leu Gln Arg Thr Thr Ser Thr Ala Gly Arg
1025                1030                1035                1040
Ser Leu Ile Glu Ala Gln Thr Cys Glu Asn Glu Glu Ala Glu Thr Val
                1045                1050                1055    
Thr Ala Met Ala Ser Leu Ser Val Gly Val Lys Pro Ala Glu Lys Arg
            1060                1065                1070        
Pro Asp Glu Glu Pro Met Glu Glu Glu Pro Pro Leu
        1075                1080                


<210> 7780
<211> 897
<212> PRT
<213> Homo sapiens

<400> 7780
Arg Leu Tyr Thr Glu Ala Trp Asp Lys Asp Lys Thr Thr Val His Ile
 1               5                  10                  15      
Met Pro Asp Thr Pro Glu Val Leu Leu Ala Lys Gln Asn Lys Val Asn
            20                  25                  30          
Tyr Ser Glu Lys Leu Tyr Lys Leu Ala Leu Glu Glu Ser Lys Lys Glu
        35                  40                  45              
Gly Tyr Asp Leu Arg Leu Asp Ala Ile Pro Ile Gln Ala Ala Lys Ala
    50                  55                  60                  
Ser Arg Asp Ile Ala Ser Asp Tyr Lys Tyr Lys Glu Gly Tyr Arg Lys
65                  70                  75                  80  
Gln Leu Gly His His Ile Gly Ala Arg Asn Ile Lys Asp Asp Pro Lys
                85                  90                  95      
Met Met Trp Ser Ile His Val Ala Lys Ile Gln Ser Asp Arg Glu Tyr
            100                 105                 110         
Lys Lys Glu Phe Glu Lys Trp Lys Thr Lys Phe Ser Ser Pro Val Asp
        115                 120                 125             
Met Leu Gly Val Val Leu Ala Lys Lys Cys Gln Ile Leu Val Ser Asp
    130                 135                 140                 
Ile Asp Tyr Lys His Pro Leu His Glu Trp Thr Cys Leu Pro Asp Gln
145                 150                 155                 160 
Asn Asp Val Ile Gln Ala Arg Lys Ala Tyr Asp Leu Gln Ser Asp Ala
                165                 170                 175     
Ile Tyr Lys Ser Asp Leu Glu Trp Leu Arg Gly Ile Gly Trp Val Pro
            180                 185                 190         
Ile Gly Ser Val Glu Val Glu Lys Val Lys Arg Ala Gly Glu Ile Leu
        195                 200                 205             
Ser Asp Arg Lys Tyr Arg Gln Pro Ala Asp Gln Leu Lys Phe Thr Cys
    210                 215                 220                 
Ile Thr Asp Thr Pro Glu Ile Val Leu Ala Lys Asn Asn Ala Leu Thr
225                 230                 235                 240 
Met Ser Lys His Leu Tyr Thr Glu Ala Trp Asp Ala Asp Lys Thr Ser
                245                 250                 255     
Ile His Val Met Pro Asp Thr Pro Asp Ile Leu Leu Ala Lys Ser Asn
            260                 265                 270         
Ser Ala Asn Ile Ser Gln Lys Leu Tyr Thr Lys Gly Trp Asp Glu Ser
        275                 280                 285             
Lys Met Lys Asp Tyr Asp Leu Arg Ala Asp Ala Ile Ser Ile Lys Ser
    290                 295                 300                 
Ala Lys Ala Ser Arg Asp Ile Ala Ser Asp Tyr Leu Tyr Lys Thr Ala
305                 310                 315                 320 
Tyr Glu Lys Gln Lys Gly His Tyr Ile Gly Cys Arg Ser Ala Lys Glu
                325                 330                 335     
Asp Pro Lys Leu Val Trp Ala Ala Asn Val Leu Lys Met Gln Asn Asp
            340                 345                 350         
Arg Leu Tyr Lys Lys Ala Tyr Asn Asp His Lys Ala Lys Ile Ser Ile
        355                 360                 365             
Pro Val Asp Met Val Ser Ile Ser Ala Ala Lys Glu Gly Gln Ala Leu
    370                 375                 380                 
Ala Ser Asp Val Asp Tyr Arg His Tyr Leu His His Trp Ser Cys Phe
385                 390                 395                 400 
Pro Asp Gln Asn Asp Val Ile Gln Ala Arg Lys Ala Tyr Asp Leu Gln
                405                 410                 415     
Ser Asp Asn Leu Tyr Lys Ser Asp Leu Glu Trp Leu Lys Gly Ile Gly
            420                 425                 430         
Trp Leu Pro Glu Gly Ser Val Glu Val Met Arg Val Lys Asn Ala Gln
        435                 440                 445             
Asn Leu Leu Asn Glu Arg Leu Tyr Arg Ile Lys Pro Glu Ala Leu Lys
    450                 455                 460                 
Phe Thr Ser Ile Val Asp Thr Pro Glu Val Ile Gln Ala Lys Ile Asn
465                 470                 475                 480 
Ala Val Gln Ile Ser Glu Lys Leu Tyr Gln Glu Ala Trp Asn Lys Asp
                485                 490                 495     
Lys Ser Asn Ile Thr Ile Pro Ser Asp Thr Pro Glu Met Leu Gln Ala
            500                 505                 510         
His Ile Asn Ala Leu Gln Ile Ser Asn Val Ser Gly Thr Asn Met Lys
        515                 520                 525             
Cys Lys Ser Leu Tyr Gly Gln Tyr Leu Leu Ser Arg Lys Ser Gly Phe
    530                 535                 540                 
Gly Lys Ile Thr Leu Leu Phe Ser Val His Ile Tyr Gln Tyr Leu Tyr
545                 550                 555                 560 
Lys Thr Ala Tyr Glu Lys Gln Lys Gly His Tyr Ile Gly Cys Arg Ser
                565                 570                 575     
Ala Lys Glu Asp Pro Lys Leu Val Trp Ala Ala Asn Val Leu Lys Met
            580                 585                 590         
Gln Asn Asp Arg Leu Tyr Lys Lys Ala Tyr Asn Asp His Lys Ala Lys
        595                 600                 605             
Ile Ser Ile Pro Val Asp Met Val Ser Ile Ser Ala Ala Lys Glu Gly
    610                 615                 620                 
Gln Ala Leu Ala Ser Asp Val Asp Tyr Arg His Tyr Leu His Arg Trp
625                 630                 635                 640 
Ser Cys Phe Pro Asp Gln Asn Asp Val Ile Gln Ala Arg Lys Ala Tyr
                645                 650                 655     
Asp Leu Gln Ser Asp Ala Leu Tyr Lys Ala Asp Leu Glu Trp Leu Arg
            660                 665                 670         
Gly Ile Gly Trp Met Pro Gln Gly Ser Pro Glu Val Leu Arg Val Lys
        675                 680                 685             
Asn Ala Gln Asn Ile Phe Cys Asp Ser Val Tyr Arg Thr Pro Val Val
    690                 695                 700                 
Asn Leu Lys Tyr Thr Ser Ile Val Asp Thr Pro Glu Val Val Leu Ala
705                 710                 715                 720 
Lys Ser Asn Ala Glu Asn Ile Ser Ile Pro Lys Tyr Arg Glu Val Trp
                725                 730                 735     
Asp Lys Asp Lys Thr Ser Ile His Ile Met Pro Asp Thr Pro Glu Ile
            740                 745                 750         
Asn Leu Ala Arg Ala Asn Ala Leu Asn Val Ser Asn Tyr Leu Tyr Lys
        755                 760                 765             
Glu Gly Trp Glu Arg Gln Lys Ala Thr Gly Tyr Ile Leu Pro Pro Asp
    770                 775                 780                 
Ala Val Pro Phe Val His Ala His His Cys Asn Asp Val Gln Ser Glu
785                 790                 795                 800 
Leu Lys Tyr Lys Ala Glu His Val Lys Gln Lys Gly His Tyr Val Gly
                805                 810                 815     
Val Pro Thr Met Arg Asp Asp Pro Lys Leu Val Trp Phe Glu His Ala
            820                 825                 830         
Gly Gln Ile Gln Asn Glu Arg Leu Tyr Lys Glu Asp Tyr His Lys Thr
        835                 840                 845             
Lys Ala Lys Ile Asn Ile Pro Ala Asp Met Val Ser Val Leu Ala Ala
    850                 855                 860                 
Lys Gln Gly Gln Thr Leu Val Ser Asp Ile Asp Tyr Arg Asn Tyr Leu
865                 870                 875                 880 
His Gln Trp Met Cys His Pro Asp Gln Asn Asp Val Ile Gln Ala Arg
                885                 890                 895     
Lys
    


<210> 7781
<211> 739
<212> PRT
<213> Homo sapiens

<400> 7781
Met Ala Ser Val Leu Gly Ser Gly Arg Gly Ser Gly Gly Leu Ser Ser
 1               5                  10                  15      
Gln Leu Lys Cys Lys Ser Lys Arg Arg Arg Arg Arg Arg Ser Lys Arg
            20                  25                  30          
Lys Asp Lys Val Ser Ile Leu Ser Thr Phe Leu Ala Pro Phe Lys His
        35                  40                  45              
Leu Ser Pro Gly Ile Thr Asn Thr Glu Asp Asp Asp Thr Leu Ser Thr
    50                  55                  60                  
Ser Ser Ala Glu Val Lys Glu Asn Arg Asn Val Gly Asn Leu Ala Ala
65                  70                  75                  80  
Arg Pro Pro Pro Ser Gly Asp Arg Ala Arg Gly Gly Ala Pro Gly Ala
                85                  90                  95      
Lys Arg Lys Arg Pro Leu Glu Glu Gly Asn Gly Gly His Leu Cys Lys
            100                 105                 110         
Leu Gln Leu Val Trp Lys Lys Leu Ser Trp Ser Val Ala Pro Lys Asn
        115                 120                 125             
Ala Leu Val Gln Leu His Glu Leu Arg Pro Gly Leu Gln Tyr Arg Thr
    130                 135                 140                 
Val Ser Gln Thr Gly Pro Val His Ala Pro Val Phe Ala Val Ala Val
145                 150                 155                 160 
Glu Val Asn Gly Leu Thr Phe Glu Gly Thr Gly Pro Thr Lys Lys Lys
                165                 170                 175     
Ala Lys Met Arg Ala Ala Glu Leu Ala Leu Arg Ser Phe Val Gln Phe
            180                 185                 190         
Pro Asn Ala Cys Gln Ala His Leu Ala Met Gly Gly Gly Pro Gly Pro
        195                 200                 205             
Gly Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu Phe
    210                 215                 220                 
Gln Glu Phe Glu Pro Pro Ala Pro Arg Pro Gly Leu Ala Gly Gly Arg
225                 230                 235                 240 
Pro Gly Asp Ala Ala Leu Leu Ser Ala Ala Tyr Gly Arg Arg Arg Leu
                245                 250                 255     
Leu Cys Arg Ala Leu Asp Leu Val Gly Pro Thr Pro Ala Thr Pro Ala
            260                 265                 270         
Ala Pro Gly Glu Arg Asn Pro Val Val Leu Leu Asn Arg Leu Arg Ala
        275                 280                 285             
Gly Leu Arg Tyr Val Cys Leu Ala Glu Pro Ala Glu Arg Arg Ala Arg
    290                 295                 300                 
Ser Phe Val Met Ala Val Ser Val Asp Gly Arg Thr Phe Glu Gly Ser
305                 310                 315                 320 
Gly Arg Ser Lys Lys Leu Ala Arg Gly Gln Ala Ala Gln Ala Ala Leu
                325                 330                 335     
Gln Glu Leu Phe Asp Ile Gln Met Pro Gly His Ala Pro Gly Arg Ala
            340                 345                 350         
Arg Arg Thr Pro Met Pro Gln Glu Phe Ala Asp Ser Ile Ser Gln Leu
        355                 360                 365             
Val Thr Gln Lys Phe Arg Glu Val Thr Thr Asp Leu Thr Pro Met His
    370                 375                 380                 
Ala Arg His Lys Ala Leu Ala Gly Ile Val Met Thr Lys Gly Leu Asp
385                 390                 395                 400 
Ala Arg Gln Ala Gln Val Val Ala Leu Ser Ser Gly Thr Lys Cys Ile
                405                 410                 415     
Ser Gly Glu His Leu Ser Asp Gln Gly Leu Val Val Asn Asp Cys His
            420                 425                 430         
Ala Glu Val Val Ala Arg Arg Ala Phe Leu His Phe Leu Tyr Thr Gln
        435                 440                 445             
Leu Glu Leu His Leu Ser Lys Arg Arg Glu Asp Ser Glu Arg Ser Ile
    450                 455                 460                 
Phe Val Arg Leu Lys Glu Gly Gly Tyr Arg Leu Arg Glu Asn Ile Leu
465                 470                 475                 480 
Phe His Leu Tyr Val Ser Thr Ser Pro Cys Gly Asp Ala Arg Leu His
                485                 490                 495     
Ser Pro Tyr Glu Ile Thr Thr Asp Leu His Ser Ser Lys His Leu Val
            500                 505                 510         
Arg Lys Phe Arg Gly His Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly
        515                 520                 525             
Thr Val Pro Val Arg Gly Pro Ser Ala Val Gln Thr Trp Asp Gly Val
    530                 535                 540                 
Leu Leu Gly Glu Gln Leu Ile Thr Met Ser Cys Thr Asp Lys Ile Ala
545                 550                 555                 560 
Arg Trp Asn Val Leu Gly Leu Gln Gly Ala Leu Leu Ser His Phe Val
                565                 570                 575     
Glu Pro Val Tyr Leu Gln Ser Ile Val Val Gly Ser Leu His His Thr
            580                 585                 590         
Gly His Leu Ala Arg Val Met Ser His Arg Met Glu Gly Val Gly Gln
        595                 600                 605             
Leu Pro Ala Ser Tyr Arg His Asn Arg Pro Leu Leu Ser Gly Val Ser
    610                 615                 620                 
Asp Ala Glu Ala Arg Gln Pro Gly Lys Ser Pro Pro Phe Ser Met Asn
625                 630                 635                 640 
Trp Val Val Gly Ser Ala Asp Leu Glu Ile Ile Asn Ala Thr Thr Gly
                645                 650                 655     
Arg Arg Ser Cys Gly Gly Pro Ser Arg Leu Cys Lys His Val Leu Ser
            660                 665                 670         
Ala Arg Trp Ala Arg Leu Tyr Gly Arg Leu Ser Thr Arg Thr Pro Ser
        675                 680                 685             
Pro Gly Asp Thr Pro Ser Met Tyr Cys Glu Ala Lys Leu Gly Ala His
    690                 695                 700                 
Thr Tyr Gln Ser Val Lys Gln Gln Leu Phe Lys Ala Phe Gln Lys Ala
705                 710                 715                 720 
Gly Leu Gly Thr Trp Val Arg Lys Pro Pro Glu Gln Gln Gln Phe Leu
                725                 730                 735     
Leu Thr Leu
            


<210> 7782
<211> 134
<212> PRT
<213> Homo sapiens

<400> 7782
Met Asn Glu Arg Glu Thr Pro Gly Gln Leu Gly Leu Gly Asn Ala Ser
 1               5                  10                  15      
Gly Val Ser Asp Ala Glu Ala Arg Gln Pro Gly Lys Ser Pro Pro Phe
            20                  25                  30          
Ser Met Asn Trp Val Val Gly Ser Ala Asp Leu Glu Ile Ile Asn Ala
        35                  40                  45              
Thr Thr Gly Arg Arg Ser Cys Gly Gly Pro Ser Arg Leu Cys Lys His
    50                  55                  60                  
Val Leu Ser Ala Arg Trp Ala Arg Leu Tyr Gly Arg Leu Ser Thr Arg
65                  70                  75                  80  
Thr Pro Ser Ala Gly Asp Thr Pro Ser Met Tyr Cys Glu Ala Lys Leu
                85                  90                  95      
Gly Ala His Thr Tyr Gln Ser Val Lys Gln Gln Leu Phe Lys Ala Phe
            100                 105                 110         
Gln Lys Ala Gly Leu Gly Thr Trp Val Arg Lys Pro Pro Glu Gln Gln
        115                 120                 125             
Gln Phe Leu Leu Thr Leu
    130                 


<210> 7783
<211> 3144
<212> PRT
<213> Homo sapiens

<400> 7783
Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser
 1               5                  10                  15      
Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            20                  25                  30          
Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro
        35                  40                  45              
Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu
    50                  55                  60                  
Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro
65                  70                  75                  80  
Ala Val Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala
                85                  90                  95      
Thr Lys Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile
            100                 105                 110         
Val Ala Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly
        115                 120                 125             
Ile Ala Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp
    130                 135                 140                 
Val Arg Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu
145                 150                 155                 160 
Met Asp Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile
                165                 170                 175     
Lys Lys Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe
            180                 185                 190         
Ala Glu Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu
        195                 200                 205             
Val Asn Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu
    210                 215                 220                 
Ser Val Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser
225                 230                 235                 240 
Phe Gly Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala
                245                 250                 255     
Phe Ile Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala
            260                 265                 270         
Ala Gly Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr
        275                 280                 285             
Phe Tyr Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val
    290                 295                 300                 
Glu Asp Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu
305                 310                 315                 320 
Arg Tyr Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu
                325                 330                 335     
Lys Gly Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser
            340                 345                 350         
Ala Glu Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln
        355                 360                 365             
His Gln Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln
    370                 375                 380                 
Leu Phe Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val
385                 390                 395                 400 
Gly Gly Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg
                405                 410                 415     
Ser Arg Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser
            420                 425                 430         
Cys Ser Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly
        435                 440                 445             
Glu Glu Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser
    450                 455                 460                 
Ser Ser Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu
465                 470                 475                 480 
Ala Ala Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile
                485                 490                 495     
Ile Thr Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val
            500                 505                 510         
Asp Leu Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu
        515                 520                 525             
Glu Asp Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser
    530                 535                 540                 
Asp Pro Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile
545                 550                 555                 560 
Ser Asp Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr
                565                 570                 575     
Pro Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr
            580                 585                 590         
Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr
        595                 600                 605             
Gly Ile Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met
    610                 615                 620                 
Ala Leu Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln
625                 630                 635                 640 
Pro Ser Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr
                645                 650                 655     
Glu Pro Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile
            660                 665                 670         
Gly Gln Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg
        675                 680                 685             
Leu Leu Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val
    690                 695                 700                 
Pro Asp Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys
705                 710                 715                 720 
Val Gly Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu
                725                 730                 735     
Tyr Lys Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val
            740                 745                 750         
Ser Asp Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly
        755                 760                 765             
Ala Thr Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg
    770                 775                 780                 
Ser Arg Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr
785                 790                 795                 800 
Gly Asn Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr
                805                 810                 815     
Leu Lys Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val
            820                 825                 830         
Arg Asn Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly
        835                 840                 845             
Leu Gln Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp
    850                 855                 860                 
Leu Val Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg
865                 870                 875                 880 
Leu Val Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala
                885                 890                 895     
His His Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn
            900                 905                 910         
Val Val Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val
        915                 920                 925             
Ala Ala Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys
    930                 935                 940                 
Asp Gln Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser
945                 950                 955                 960 
Ser Val Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His
                965                 970                 975     
Phe Ser Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu
            980                 985                 990         
Pro Ser Ile Thr Asp Val Thr Met Glu Asn Asn Leu Ser Arg Val Ile
        995                 1000                1005            
Ala Ala Val Ser His Glu Leu Ile Thr Ser Thr Thr Arg Ala Leu Thr
    1010                1015                1020                
Phe Gly Cys Cys Glu Ala Leu Cys Leu Leu Ser Thr Ala Phe Pro Val
1025                1030                1035                1040
Cys Ile Trp Ser Leu Gly Trp His Cys Gly Val Pro Pro Leu Ser Ala
                1045                1050                1055    
Ser Asp Glu Ser Arg Lys Ser Cys Thr Val Gly Met Ala Thr Met Ile
            1060                1065                1070        
Leu Thr Leu Leu Ser Ser Ala Trp Phe Pro Leu Asp Leu Ser Ala His
        1075                1080                1085            
Gln Asp Ala Leu Ile Leu Ala Gly Asn Leu Leu Ala Ala Ser Ala Pro
    1090                1095                1100                
Lys Ser Leu Arg Ser Ser Trp Ala Ser Glu Glu Glu Ala Asn Pro Ala
1105                1110                1115                1120
Ala Thr Lys Gln Glu Glu Val Trp Pro Ala Leu Gly Asp Arg Ala Leu
                1125                1130                1135    
Val Pro Met Val Glu Gln Leu Phe Ser His Leu Leu Lys Val Ile Asn
            1140                1145                1150        
Ile Cys Ala His Val Leu Asp Asp Val Ala Pro Gly Pro Ala Ile Lys
        1155                1160                1165            
Ala Ala Leu Pro Ser Leu Thr Asn Pro Pro Ser Leu Ser Pro Ile Arg
    1170                1175                1180                
Arg Lys Gly Lys Glu Lys Glu Pro Gly Glu Gln Ala Ser Val Pro Leu
1185                1190                1195                1200
Ser Pro Lys Lys Gly Ser Glu Ala Ser Ala Ala Ser Arg Gln Ser Asp
                1205                1210                1215    
Thr Ser Gly Pro Val Thr Thr Ser Lys Ser Ser Ser Leu Gly Ser Phe
            1220                1225                1230        
Tyr His Leu Pro Ser Tyr Leu Lys Leu His Asp Val Leu Lys Ala Thr
        1235                1240                1245            
His Ala Asn Tyr Lys Val Thr Leu Asp Leu Gln Asn Ser Thr Glu Lys
    1250                1255                1260                
Phe Gly Gly Phe Leu Arg Ser Ala Leu Asp Val Leu Ser Gln Ile Leu
1265                1270                1275                1280
Glu Leu Ala Thr Leu Gln Asp Ile Gly Lys Cys Val Glu Glu Ile Leu
                1285                1290                1295    
Gly Tyr Leu Lys Ser Cys Phe Ser Arg Glu Pro Met Met Ala Thr Val
            1300                1305                1310        
Cys Val Gln Gln Leu Leu Lys Thr Leu Phe Gly Thr Asn Leu Ala Ser
        1315                1320                1325            
Gln Phe Asp Gly Leu Ser Ser Asn Pro Ser Lys Ser Gln Gly Arg Ala
    1330                1335                1340                
Gln Arg Leu Gly Ser Ser Ser Val Arg Pro Gly Leu Tyr His Tyr Cys
1345                1350                1355                1360
Phe Met Ala Pro Tyr Thr His Phe Thr Gln Ala Leu Ala Asp Ala Ser
                1365                1370                1375    
Leu Arg Asn Met Val Gln Ala Glu Gln Glu Asn Asp Thr Ser Gly Trp
            1380                1385                1390        
Phe Asp Val Leu Gln Lys Val Ser Thr Gln Leu Lys Thr Asn Leu Thr
        1395                1400                1405            
Ser Val Thr Lys Asn Arg Ala Asp Lys Asn Ala Ile His Asn His Ile
    1410                1415                1420                
Arg Leu Phe Glu Pro Leu Val Ile Lys Ala Leu Lys Gln Tyr Thr Thr
1425                1430                1435                1440
Thr Thr Cys Val Gln Leu Gln Lys Gln Val Leu Asp Leu Leu Ala Gln
                1445                1450                1455    
Leu Val Gln Leu Arg Val Asn Tyr Cys Leu Leu Asp Ser Asp Gln Val
            1460                1465                1470        
Phe Ile Gly Phe Val Leu Lys Gln Phe Glu Tyr Ile Glu Val Gly Gln
        1475                1480                1485            
Phe Arg Glu Ser Glu Ala Ile Ile Pro Asn Ile Phe Phe Phe Leu Val
    1490                1495                1500                
Leu Leu Ser Tyr Glu Arg Tyr His Ser Lys Gln Ile Ile Gly Ile Pro
1505                1510                1515                1520
Lys Ile Ile Gln Leu Cys Asp Gly Ile Met Ala Ser Gly Arg Lys Ala
                1525                1530                1535    
Val Thr His Ala Ile Pro Ala Leu Gln Pro Ile Val His Asp Leu Phe
            1540                1545                1550        
Val Leu Arg Gly Thr Asn Lys Ala Asp Ala Gly Lys Glu Leu Glu Thr
        1555                1560                1565            
Gln Lys Glu Val Val Val Ser Met Leu Leu Arg Leu Ile Gln Tyr His
    1570                1575                1580                
Gln Val Leu Glu Met Phe Ile Leu Val Leu Gln Gln Cys His Lys Glu
1585                1590                1595                1600
Asn Glu Asp Lys Trp Lys Arg Leu Ser Arg Gln Ile Ala Asp Ile Ile
                1605                1610                1615    
Leu Pro Met Leu Ala Lys Gln Gln Met His Ile Asp Ser His Glu Ala
            1620                1625                1630        
Leu Gly Val Leu Asn Thr Leu Phe Glu Ile Leu Ala Pro Ser Ser Leu
        1635                1640                1645            
Arg Pro Val Asp Met Leu Leu Arg Ser Met Phe Val Thr Pro Asn Thr
    1650                1655                1660                
Met Ala Ser Val Ser Thr Val Gln Leu Trp Ile Ser Gly Ile Leu Ala
1665                1670                1675                1680
Ile Leu Arg Val Leu Ile Ser Gln Ser Thr Glu Asp Ile Val Leu Ser
                1685                1690                1695    
Arg Ile Gln Glu Leu Ser Phe Ser Pro Tyr Leu Ile Ser Cys Thr Val
            1700                1705                1710        
Ile Asn Arg Leu Arg Asp Gly Asp Ser Thr Ser Thr Leu Glu Glu His
        1715                1720                1725            
Ser Glu Gly Lys Gln Ile Lys Asn Leu Pro Glu Glu Thr Phe Ser Arg
    1730                1735                1740                
Phe Leu Leu Gln Leu Val Gly Ile Leu Leu Glu Asp Ile Val Thr Lys
1745                1750                1755                1760
Gln Leu Lys Val Glu Met Ser Glu Gln Gln His Thr Phe Tyr Cys Gln
                1765                1770                1775    
Glu Leu Gly Thr Leu Leu Met Cys Leu Ile His Ile Phe Lys Ser Gly
            1780                1785                1790        
Met Phe Arg Arg Ile Thr Ala Ala Ala Thr Arg Leu Phe Arg Ser Asp
        1795                1800                1805            
Gly Cys Gly Gly Ser Phe Tyr Thr Leu Asp Ser Leu Asn Leu Arg Ala
    1810                1815                1820                
Arg Ser Met Ile Thr Thr His Pro Ala Leu Val Leu Leu Trp Cys Gln
1825                1830                1835                1840
Ile Leu Leu Leu Val Asn His Thr Asp Tyr Arg Trp Trp Ala Glu Val
                1845                1850                1855    
Gln Gln Thr Pro Lys Arg His Ser Leu Ser Ser Thr Lys Leu Leu Ser
            1860                1865                1870        
Pro Gln Met Ser Gly Glu Glu Glu Asp Ser Asp Leu Ala Ala Lys Leu
        1875                1880                1885            
Gly Met Cys Asn Arg Glu Ile Val Arg Arg Gly Ala Leu Ile Leu Phe
    1890                1895                1900                
Cys Asp Tyr Val Cys Gln Asn Leu His Asp Ser Glu His Leu Thr Trp
1905                1910                1915                1920
Leu Ile Val Asn His Ile Gln Asp Leu Ile Ser Leu Ser His Glu Pro
                1925                1930                1935    
Pro Val Gln Asp Phe Ile Ser Ala Val His Arg Asn Ser Ala Ala Ser
            1940                1945                1950        
Gly Leu Phe Ile Gln Ala Ile Gln Ser Arg Cys Glu Asn Leu Ser Thr
        1955                1960                1965            
Pro Thr Met Leu Lys Lys Thr Leu Gln Cys Leu Glu Gly Ile His Leu
    1970                1975                1980                
Ser Gln Ser Gly Ala Val Leu Thr Leu Tyr Val Asp Arg Leu Leu Cys
1985                1990                1995                2000
Thr Pro Phe Arg Val Leu Ala Arg Met Val Asp Ile Leu Ala Cys Arg
                2005                2010                2015    
Arg Val Glu Met Leu Leu Ala Ala Asn Leu Gln Ser Ser Met Ala Gln
            2020                2025                2030        
Leu Pro Met Glu Glu Leu Asn Arg Ile Gln Glu Tyr Leu Gln Ser Ser
        2035                2040                2045            
Gly Leu Ala Gln Arg His Gln Arg Leu Tyr Ser Leu Leu Asp Arg Phe
    2050                2055                2060                
Arg Leu Ser Thr Met Gln Asp Ser Leu Ser Pro Ser Pro Pro Val Ser
2065                2070                2075                2080
Ser His Pro Leu Asp Gly Asp Gly His Val Ser Leu Glu Thr Val Ser
                2085                2090                2095    
Pro Asp Lys Asp Trp Tyr Val His Leu Val Lys Ser Gln Cys Trp Thr
            2100                2105                2110        
Arg Ser Asp Ser Ala Leu Leu Glu Gly Ala Glu Leu Val Asn Arg Ile
        2115                2120                2125            
Pro Ala Glu Asp Met Asn Ala Phe Met Met Asn Ser Glu Phe Asn Leu
    2130                2135                2140                
Ser Leu Leu Ala Pro Cys Leu Ser Leu Gly Met Ser Glu Ile Ser Gly
2145                2150                2155                2160
Gly Gln Lys Ser Ala Leu Phe Glu Ala Ala Arg Glu Val Thr Leu Ala
                2165                2170                2175    
Arg Val Ser Gly Thr Val Gln Gln Leu Pro Ala Val His His Val Phe
            2180                2185                2190        
Gln Pro Glu Leu Pro Ala Glu Pro Ala Ala Tyr Trp Ser Lys Leu Asn
        2195                2200                2205            
Asp Leu Phe Gly Asp Ala Ala Leu Tyr Gln Ser Leu Pro Thr Leu Ala
    2210                2215                2220                
Arg Ala Leu Ala Gln Tyr Leu Val Val Val Ser Lys Leu Pro Ser His
2225                2230                2235                2240
Leu His Leu Pro Pro Glu Lys Glu Lys Asp Ile Val Lys Phe Val Val
                2245                2250                2255    
Ala Thr Leu Glu Ala Leu Ser Trp His Leu Ile His Glu Gln Ile Pro
            2260                2265                2270        
Leu Ser Leu Asp Leu Gln Ala Gly Leu Asp Cys Cys Cys Leu Ala Leu
        2275                2280                2285            
Gln Leu Pro Gly Leu Trp Ser Val Val Ser Ser Thr Glu Phe Val Thr
    2290                2295                2300                
His Ala Cys Ser Leu Ile Tyr Cys Val His Phe Ile Leu Glu Ala Val
2305                2310                2315                2320
Ala Val Gln Pro Gly Glu Gln Leu Leu Ser Pro Glu Arg Arg Thr Asn
                2325                2330                2335    
Thr Pro Lys Ala Ile Ser Glu Glu Glu Glu Glu Val Asp Pro Asn Thr
            2340                2345                2350        
Gln Asn Pro Lys Tyr Ile Thr Ala Ala Cys Glu Met Val Ala Glu Met
        2355                2360                2365            
Val Glu Ser Leu Gln Ser Val Leu Ala Leu Gly His Lys Arg Asn Ser
    2370                2375                2380                
Gly Val Pro Ala Phe Leu Thr Pro Leu Leu Arg Asn Ile Ile Ile Ser
2385                2390                2395                2400
Leu Ala Arg Leu Pro Leu Val Asn Ser Tyr Thr Arg Val Pro Pro Leu
                2405                2410                2415    
Val Trp Lys Leu Gly Trp Ser Pro Lys Pro Gly Gly Asp Phe Gly Thr
            2420                2425                2430        
Ala Phe Pro Glu Ile Pro Val Glu Phe Leu Gln Glu Lys Glu Val Phe
        2435                2440                2445            
Lys Glu Phe Ile Tyr Arg Ile Asn Thr Leu Gly Trp Thr Ser Arg Thr
    2450                2455                2460                
Gln Phe Glu Glu Thr Trp Ala Thr Leu Leu Gly Val Leu Val Thr Gln
2465                2470                2475                2480
Pro Leu Val Met Glu Gln Glu Glu Ser Pro Pro Glu Glu Asp Thr Glu
                2485                2490                2495    
Arg Thr Gln Ile Asn Val Leu Ala Val Gln Ala Ile Thr Ser Leu Val
            2500                2505                2510        
Leu Ser Ala Met Thr Val Pro Val Ala Gly Asn Pro Ala Val Ser Cys
        2515                2520                2525            
Leu Glu Gln Gln Pro Arg Asn Lys Pro Leu Lys Ala Leu Asp Thr Arg
    2530                2535                2540                
Phe Gly Arg Lys Leu Ser Ile Ile Arg Gly Ile Val Glu Gln Glu Ile
2545                2550                2555                2560
Gln Ala Met Val Ser Lys Arg Glu Asn Ile Ala Thr His His Leu Tyr
                2565                2570                2575    
Gln Ala Trp Asp Pro Val Pro Ser Leu Ser Pro Ala Thr Thr Gly Ala
            2580                2585                2590        
Leu Ile Ser His Glu Lys Leu Leu Leu Gln Ile Asn Pro Glu Arg Glu
        2595                2600                2605            
Leu Gly Ser Met Ser Tyr Lys Leu Gly Gln Val Ser Ile His Ser Val
    2610                2615                2620                
Trp Leu Gly Asn Ser Ile Thr Pro Leu Arg Glu Glu Glu Trp Asp Glu
2625                2630                2635                2640
Glu Glu Glu Glu Glu Ala Asp Ala Pro Ala Pro Ser Ser Pro Pro Thr
                2645                2650                2655    
Ser Pro Val Asn Ser Arg Lys His Arg Ala Gly Val Asp Ile His Ser
            2660                2665                2670        
Cys Ser Gln Phe Leu Leu Glu Leu Tyr Ser Arg Trp Ile Leu Pro Ser
        2675                2680                2685            
Ser Ser Ala Arg Arg Thr Pro Ala Ile Leu Ile Ser Glu Val Val Arg
    2690                2695                2700                
Ser Leu Leu Val Val Ser Asp Leu Phe Thr Glu Arg Asn Gln Phe Glu
2705                2710                2715                2720
Leu Met Tyr Val Thr Leu Thr Glu Leu Arg Arg Val His Pro Ser Glu
                2725                2730                2735    
Asp Glu Ile Leu Ala Gln Tyr Leu Val Pro Ala Thr Cys Lys Ala Ala
            2740                2745                2750        
Ala Val Leu Gly Met Asp Lys Ala Val Ala Glu Pro Val Ser Arg Leu
        2755                2760                2765            
Leu Glu Ser Thr Leu Arg Ser Ser His Leu Pro Ser Arg Val Gly Ala
    2770                2775                2780                
Leu His Gly Val Leu Tyr Val Leu Glu Cys Asp Leu Leu Asp Asp Thr
2785                2790                2795                2800
Ala Lys Gln Leu Ile Pro Val Ile Ser Asp Tyr Leu Leu Ser Asn Leu
                2805                2810                2815    
Lys Gly Ile Ala His Cys Val Asn Ile His Ser Gln Gln His Val Leu
            2820                2825                2830        
Val Met Cys Ala Thr Ala Phe Tyr Leu Ile Glu Asn Tyr Pro Leu Asp
        2835                2840                2845            
Val Gly Pro Glu Phe Ser Ala Ser Ile Ile Gln Met Cys Gly Val Met
    2850                2855                2860                
Leu Ser Gly Ser Glu Glu Ser Thr Pro Ser Ile Ile Tyr His Cys Ala
2865                2870                2875                2880
Leu Arg Gly Leu Glu Arg Leu Leu Leu Ser Glu Gln Leu Ser Arg Leu
                2885                2890                2895    
Asp Ala Glu Ser Leu Val Lys Leu Ser Val Asp Arg Val Asn Val His
            2900                2905                2910        
Ser Pro His Arg Ala Met Ala Ala Leu Gly Leu Met Leu Thr Cys Met
        2915                2920                2925            
Tyr Thr Gly Lys Glu Lys Val Ser Pro Gly Arg Thr Ser Asp Pro Asn
    2930                2935                2940                
Pro Ala Ala Pro Asp Ser Glu Ser Val Ile Val Ala Met Glu Arg Val
2945                2950                2955                2960
Ser Val Leu Phe Asp Arg Ile Arg Lys Gly Phe Pro Cys Glu Ala Arg
                2965                2970                2975    
Val Val Ala Arg Ile Leu Pro Gln Phe Leu Asp Asp Phe Phe Pro Pro
            2980                2985                2990        
Gln Asp Ile Met Asn Lys Val Ile Gly Glu Phe Leu Ser Asn Gln Gln
        2995                3000                3005            
Pro Tyr Pro Gln Phe Met Ala Thr Val Val Tyr Lys Val Phe Gln Thr
    3010                3015                3020                
Leu His Ser Thr Gly Gln Ser Ser Met Val Arg Asp Trp Val Met Leu
3025                3030                3035                3040
Ser Leu Ser Asn Phe Thr Gln Arg Ala Pro Val Ala Met Ala Thr Trp
                3045                3050                3055    
Ser Leu Ser Cys Phe Phe Val Ser Ala Ser Thr Ser Pro Trp Val Ala
            3060                3065                3070        
Ala Ile Leu Pro His Val Ile Ser Arg Met Gly Lys Leu Glu Gln Val
        3075                3080                3085            
Asp Val Asn Leu Phe Cys Leu Val Ala Thr Asp Phe Tyr Arg His Gln
    3090                3095                3100                
Ile Glu Glu Glu Leu Asp Arg Arg Ala Phe Gln Ser Val Leu Glu Val
3105                3110                3115                3120
Val Ala Ala Pro Gly Ser Pro Tyr His Arg Leu Leu Thr Cys Leu Arg
                3125                3130                3135    
Asn Val His Lys Val Thr Thr Cys
            3140                


<210> 7784
<211> 1202
<212> PRT
<213> Homo sapiens

<400> 7784
Gln Leu Glu Lys Asp Lys Lys Gln Leu Glu Lys Glu Asn Lys Arg Leu
 1               5                  10                  15      
Arg Gln Gln Ala Glu Ile Lys Asp Thr Thr Leu Glu Glu Asn Asn Val
            20                  25                  30          
Lys Ile Gly Asn Leu Glu Lys Glu Asn Lys Thr Leu Ser Lys Glu Ile
        35                  40                  45              
Gly Ile Tyr Lys Glu Ser Cys Val Arg Leu Lys Glu Leu Glu Lys Glu
    50                  55                  60                  
Asn Lys Glu Leu Val Lys Arg Ala Thr Ile Asp Ile Lys Thr Leu Val
65                  70                  75                  80  
Thr Leu Arg Glu Asp Leu Val Ser Glu Lys Leu Lys Thr Gln Gln Met
                85                  90                  95      
Asn Asn Asp Leu Glu Lys Leu Thr His Glu Leu Glu Lys Ile Gly Leu
            100                 105                 110         
Asn Lys Glu Arg Leu Leu His Asp Glu Gln Ser Thr Asp Asp Ser Arg
        115                 120                 125             
Tyr Lys Leu Leu Glu Ser Lys Leu Glu Ser Thr Leu Lys Lys Ser Leu
    130                 135                 140                 
Glu Ile Lys Glu Glu Lys Ile Ala Ala Leu Glu Ala Arg Leu Glu Glu
145                 150                 155                 160 
Ser Thr Asn Tyr Asn Gln Gln Leu Arg Gln Glu Leu Lys Thr Val Lys
                165                 170                 175     
Lys Asn Tyr Glu Ala Leu Lys Gln Arg Gln Asp Glu Glu Arg Met Val
            180                 185                 190         
Gln Ser Ser Pro Pro Ile Ser Gly Glu Asp Asn Lys Trp Glu Arg Glu
        195                 200                 205             
Ser Gln Glu Thr Thr Arg Glu Leu Leu Lys Val Lys Asp Arg Leu Ile
    210                 215                 220                 
Glu Val Glu Arg Asn Asn Ala Thr Leu Gln Ala Glu Lys Gln Ala Leu
225                 230                 235                 240 
Lys Thr Gln Leu Lys Gln Leu Glu Thr Gln Asn Asn Asn Leu Gln Thr
                245                 250                 255     
Gln Ile Leu Ala Leu Gln Arg Gln Thr Val Ser Leu Gln Glu Gln Asn
            260                 265                 270         
Thr Thr Leu Gln Thr Gln Asn Ala Lys Leu Gln Val Glu Asn Ser Thr
        275                 280                 285             
Leu Asn Ser Gln Ser Thr Ser Leu Met Asn Gln Asn Ala Gln Leu Leu
    290                 295                 300                 
Ile Gln Gln Ser Ser Leu Glu Asn Glu Asn Glu Ser Val Ile Lys Glu
305                 310                 315                 320 
Arg Glu Asp Leu Lys Ser Leu Tyr Asp Ser Leu Ile Lys Asp His Glu
                325                 330                 335     
Lys Leu Glu Leu Leu His Glu Arg Gln Ala Ser Glu Tyr Glu Ser Leu
            340                 345                 350         
Ile Ser Lys His Gly Thr Leu Lys Ser Ala His Lys Asn Leu Glu Val
        355                 360                 365             
Glu His Arg Asp Leu Glu Asp Arg Tyr Asn Gln Leu Leu Lys Gln Lys
    370                 375                 380                 
Gly Gln Leu Glu Asp Leu Glu Lys Met Leu Lys Val Glu Gln Glu Lys
385                 390                 395                 400 
Met Leu Leu Glu Asn Lys Asn His Glu Thr Val Ala Ala Glu Tyr Lys
                405                 410                 415     
Lys Leu Cys Gly Glu Asn Asp Arg Leu Asn His Thr Tyr Ser Gln Leu
            420                 425                 430         
Leu Lys Glu Thr Glu Val Leu Gln Thr Asp His Lys Asn Leu Lys Ser
        435                 440                 445             
Leu Leu Asn Asn Ser Lys Leu Glu Gln Thr Arg Leu Glu Ala Glu Phe
    450                 455                 460                 
Ser Lys Leu Lys Glu Gln Tyr Gln Gln Leu Asp Ile Thr Ser Thr Lys
465                 470                 475                 480 
Leu Asn Asn Gln Cys Glu Leu Leu Ser Gln Leu Lys Gly Asn Leu Glu
                485                 490                 495     
Glu Glu Asn Arg His Leu Leu Asp Gln Ile Gln Thr Leu Met Leu Gln
            500                 505                 510         
Asn Arg Thr Leu Leu Glu Gln Asn Met Glu Ser Lys Asp Leu Phe His
        515                 520                 525             
Val Glu Gln Arg Gln Tyr Ile Asp Lys Leu Asn Glu Leu Arg Arg Gln
    530                 535                 540                 
Lys Glu Lys Leu Glu Glu Lys Ile Met Asp Gln Tyr Lys Phe Tyr Asp
545                 550                 555                 560 
Pro Ser Pro Pro Arg Arg Arg Gly Asn Trp Ile Thr Leu Lys Met Arg
                565                 570                 575     
Lys Leu Ile Lys Ser Lys Lys Asp Ile Asn Arg Glu Arg Gln Lys Ser
            580                 585                 590         
Leu Thr Leu Thr Pro Thr Arg Ser Asp Ser Ser Glu Gly Phe Leu Gln
        595                 600                 605             
Leu Pro His Gln Asp Ser Gln Asp Ser Ser Ser Val Gly Ser Asn Ser
    610                 615                 620                 
Leu Glu Asp Gly Gln Thr Leu Gly Thr Lys Lys Ser Ser Met Val Ala
625                 630                 635                 640 
Leu Lys Arg Leu Pro Phe Leu Arg Asn Arg Pro Lys Asp Lys Asp Lys
                645                 650                 655     
Met Lys Ala Cys Tyr Arg Arg Ser Met Ser Met Asn Asp Leu Val Gln
            660                 665                 670         
Ser Met Val Leu Ala Gly Gln Trp Thr Gly Ser Thr Glu Asn Leu Glu
        675                 680                 685             
Val Pro Asp Asp Ile Ser Thr Gly Lys Arg Arg Lys Glu Leu Gly Ala
    690                 695                 700                 
Met Ala Phe Ser Thr Thr Ala Ile Asn Phe Ser Thr Val Asn Ser Ser
705                 710                 715                 720 
Ala Gly Phe Arg Ser Lys Gln Leu Val Asn Asn Lys Asp Thr Thr Ser
                725                 730                 735     
Phe Glu Asp Ile Ser Pro Gln Gly Val Ser Asp Asp Ser Ser Thr Gly
            740                 745                 750         
Ser Arg Val His Ala Ser Arg Pro Ala Ser Leu Asp Ser Gly Arg Thr
        755                 760                 765             
Ser Thr Ser Asn Ser Asn Asn Asn Ala Ser Leu His Glu Val Lys Ala
    770                 775                 780                 
Gly Ala Val Asn Asn Gln Ser Arg Pro Gln Ser His Ser Ser Gly Glu
785                 790                 795                 800 
Phe Ser Leu Leu His Asp His Glu Ala Trp Ser Ser Ser Gly Ser Ser
                805                 810                 815     
Pro Ile Gln Tyr Leu Lys Arg Gln Thr Arg Ser Ser Pro Val Leu Gln
            820                 825                 830         
His Lys Ile Pro Glu Thr Leu Glu Ser Arg His His Lys Ile Lys Thr
        835                 840                 845             
Gly Ser Pro Gly Ser Glu Val Val Thr Leu Gln Gln Phe Leu Glu Glu
    850                 855                 860                 
Ser Asn Lys Leu Thr Ser Val Gln Ile Lys Ser Ser Ser Gln Glu Asn
865                 870                 875                 880 
Leu Leu Asp Glu Val Met Lys Ser Leu Ser Val Ser Ser Asp Phe Leu
                885                 890                 895     
Gly Lys Asp Lys Pro Val Ser Cys Gly Leu Ala Arg Ser Val Ser Gly
            900                 905                 910         
Lys Thr Pro Gly Asp Phe Tyr Asp Arg Arg Thr Thr Lys Pro Glu Phe
        915                 920                 925             
Leu Arg Pro Gly Pro Arg Lys Thr Glu Asp Thr Tyr Phe Ile Ser Ser
    930                 935                 940                 
Ala Gly Lys Pro Thr Pro Gly Thr Gln Gly Lys Ile Lys Leu Val Lys
945                 950                 955                 960 
Glu Ser Ser Leu Ser Arg Gln Ser Lys Asp Ser Asn Pro Tyr Ala Thr
                965                 970                 975     
Leu Pro Arg Ala Ser Ser Val Ile Ser Thr Ala Glu Gly Thr Thr Arg
            980                 985                 990         
Arg Thr Ser Ile His Asp Phe Leu Thr Lys Asp Ser Arg Leu Pro Ile
        995                 1000                1005            
Ser Val Asp Ser Pro Pro Ala Ala Ala Asp Ser Asn Thr Thr Ala Ala
    1010                1015                1020                
Ser Ser Glu Tyr His Leu His Gln Trp Ser Ser His Ile Leu Asp Ile
1025                1030                1035                1040
Pro Thr His Thr Ile Gly Ser Cys Ala Gln Asn Asp Leu Ala Ile Asp
                1045                1050                1055    
Met Pro Glu Pro Leu Tyr Ala Gln Ala Arg Asn Ser Arg Thr Gly Arg
            1060                1065                1070        
Ser His Phe Leu Asn Gln Thr Phe Ala Thr Ile Arg Met Pro Ser Asp
        1075                1080                1085            
Ala Phe Gly Met Leu Ala Lys Asp Ser Ile Gly Pro Phe Thr Val Ala
    1090                1095                1100                
His Ser Ser Gln Pro Phe Leu Ser Leu Asn Thr Glu Leu Val Ser Asn
1105                1110                1115                1120
Ile Ser Gly Leu Pro Pro Arg Pro Val Ile Arg Ile Thr Asp Gln Ala
                1125                1130                1135    
Ser Ala Ser Leu Asp Lys Pro Ala Gln Lys Glu Asn Glu Gln Phe Ser
            1140                1145                1150        
Asp His Gln Asn Pro Ser Asn Ser Asn Leu Gln Phe Ser Ile Asn Ser
        1155                1160                1165            
Asn Asn Leu Val Thr Ser Ala Cys Leu Tyr Pro Asp Asp Thr Glu Ala
    1170                1175                1180                
Ala Leu Leu Val Ser Glu Asp Asn Gln Thr Val Trp Tyr Glu Tyr Gly
1185                1190                1195                1200
Cys Ile
        


<210> 7785
<211> 802
<212> PRT
<213> Homo sapiens

<400> 7785
His Ala Ser Ala Asp Ala Trp Val Glu Val Glu Arg Asn Asn Ala Thr
 1               5                  10                  15      
Leu Gln Ala Glu Lys Gln Ala Leu Lys Thr Gln Leu Lys Gln Leu Glu
            20                  25                  30          
Thr Gln Asn Asn Asn Leu Gln Ala Gln Ile Leu Ala Leu Gln Arg Gln
        35                  40                  45              
Thr Val Ser Leu Gln Glu Gln Asn Thr Thr Leu Gln Thr Gln Asn Ala
    50                  55                  60                  
Lys Leu Gln Val Glu Asn Ser Thr Leu Asn Ser Gln Ser Thr Ser Leu
65                  70                  75                  80  
Met Asn Gln Asn Ala Gln Leu Leu Ile Gln Gln Ser Ser Leu Glu Asn
                85                  90                  95      
Glu Asn Glu Ser Val Ile Lys Glu Arg Glu Asp Leu Lys Ser Leu Tyr
            100                 105                 110         
Asp Ser Leu Ile Lys Asp His Glu Lys Leu Glu Leu Leu His Glu Arg
        115                 120                 125             
Gln Ala Ser Glu Tyr Glu Ser Leu Ile Ser Lys His Gly Thr Leu Lys
    130                 135                 140                 
Ser Ala His Lys Asn Leu Glu Val Glu His Arg Asp Leu Glu Asp Arg
145                 150                 155                 160 
Tyr Asn Gln Leu Leu Lys Gln Lys Gly Gln Leu Glu Asp Leu Glu Lys
                165                 170                 175     
Met Leu Lys Val Glu Gln Glu Lys Met Leu Leu Glu Asn Lys Asn His
            180                 185                 190         
Glu Thr Val Ala Ala Glu Tyr Lys Lys Leu Cys Gly Glu Asn Asp Arg
        195                 200                 205             
Leu Asn His Thr Tyr Ser Gln Leu Leu Lys Glu Thr Glu Val Leu Gln
    210                 215                 220                 
Thr Asp His Lys Asn Leu Lys Ser Leu Leu Asn Asn Ser Lys Leu Glu
225                 230                 235                 240 
Gln Thr Arg Leu Glu Ala Glu Phe Ser Lys Leu Lys Glu Gln Tyr Gln
                245                 250                 255     
Gln Leu Asp Ile Thr Ser Thr Lys Leu Asn Asn Gln Cys Glu Leu Leu
            260                 265                 270         
Ser Gln Leu Lys Gly Asn Leu Glu Glu Glu Asn Arg His Leu Leu Asp
        275                 280                 285             
Gln Ile Gln Thr Leu Met Leu Gln Asn Arg Thr Leu Leu Glu Gln Asn
    290                 295                 300                 
Met Glu Ser Lys Asp Leu Phe His Val Glu Gln Arg Gln Tyr Ile Asp
305                 310                 315                 320 
Lys Leu Asn Glu Leu Arg Arg Gln Lys Glu Lys Leu Glu Glu Lys Ile
                325                 330                 335     
Met Asp Gln Tyr Lys Phe Tyr Asp Pro Ser Pro Pro Arg Arg Arg Gly
            340                 345                 350         
Asn Trp Ile Thr Leu Lys Met Arg Lys Leu Ile Lys Ser Lys Lys Asp
        355                 360                 365             
Ile Asn Arg Glu Arg Gln Lys Ser Leu Thr Leu Thr Pro Thr Arg Ser
    370                 375                 380                 
Asp Ser Ser Glu Gly Phe Leu Gln Leu Pro His Gln Asp Ser Gln Asp
385                 390                 395                 400 
Ser Ser Ser Val Gly Ser Asn Ser Leu Glu Asp Gly Gln Thr Leu Gly
                405                 410                 415     
Thr Lys Lys Ser Ser Thr Met Asn Asp Leu Val Gln Ser Met Val Leu
            420                 425                 430         
Ala Gly Gln Trp Thr Gly Ser Thr Glu Asn Leu Glu Val Pro Asp Asp
        435                 440                 445             
Ile Ser Thr Gly Lys Arg Arg Lys Glu Leu Gly Ala Met Ala Phe Ser
    450                 455                 460                 
Thr Thr Ala Ile Asn Phe Ser Thr Val Asn Ser Ser Ala Gly Phe Arg
465                 470                 475                 480 
Ser Lys Gln Leu Val Asn Asn Lys Asp Thr Thr Ser Phe Glu Asp Ile
                485                 490                 495     
Ser Pro Gln Gly Val Ser Asp Asp Ser Ser Thr Gly Ser Arg Val His
            500                 505                 510         
Ala Ser Arg Pro Ala Ser Leu Asp Ser Gly Arg Thr Ser Thr Ser Asn
        515                 520                 525             
Ser Asn Asn Asn Ala Ser Leu His Glu Val Lys Ala Gly Ala Val Asn
    530                 535                 540                 
Asn Gln Ser Arg Pro Gln Ser His Ser Ser Gly Glu Phe Ser Leu Leu
545                 550                 555                 560 
His Asp His Glu Ala Trp Ser Ser Ser Gly Ser Ser Pro Ile Gln Tyr
                565                 570                 575     
Leu Lys Arg Gln Thr Arg Ser Ser Pro Val Leu Gln His Lys Ile Ser
            580                 585                 590         
Glu Thr Leu Glu Ser Arg His His Lys Ile Lys Thr Gly Ser Pro Gly
        595                 600                 605             
Ser Glu Val Val Thr Leu Gln Gln Phe Leu Glu Glu Ser Asn Lys Leu
    610                 615                 620                 
Thr Ser Val Gln Ile Lys Ser Ser Ser Gln Glu Asn Leu Leu Asp Glu
625                 630                 635                 640 
Val Met Lys Ser Leu Ser Val Ser Ser Asp Phe Leu Gly Lys Asp Lys
                645                 650                 655     
Pro Val Ser Cys Gly Leu Ala Arg Ser Val Ser Gly Lys Thr Pro Gly
            660                 665                 670         
Asp Phe Tyr Asp Arg Arg Thr Thr Lys Pro Glu Phe Leu Arg Pro Gly
        675                 680                 685             
Pro Arg Lys Thr Glu Asp Thr Tyr Phe Ile Ser Ser Ala Gly Lys Pro
    690                 695                 700                 
Thr Pro Gly Thr Gln Gly Lys Ile Lys Leu Val Lys Glu Ser Ser Leu
705                 710                 715                 720 
Ser Arg Gln Ser Lys Asp Ser Asn Pro Tyr Ala Thr Leu Pro Arg Ala
                725                 730                 735     
Ser Ser Val Ile Ser Thr Ala Glu Gly Thr Thr Arg Arg Thr Ser Ile
            740                 745                 750         
His Asp Phe Leu Thr Lys Asp Ser Arg Leu Pro Ile Ser Val Asp Ser
        755                 760                 765             
Pro Pro Ala Ala Ala Asp Ser Asn Thr Thr Ala Ala Ser Asn Val Asp
    770                 775                 780                 
Lys Val Gln Glu Ser Arg Asn Ser Lys Ser Arg Ser Arg Glu Gln Gln
785                 790                 795                 800 
Ser Ser
        


<210> 7786
<211> 4687
<212> PRT
<213> Homo sapiens

<400> 7786
Met Val Ala Gly Met Leu Met Pro Arg Asp Gln Leu Arg Ala Ile Tyr
 1               5                  10                  15      
Glu Val Leu Phe Arg Glu Gly Val Met Val Ala Lys Lys Asp Arg Arg
            20                  25                  30          
Pro Arg Ser Leu His Pro His Val Pro Gly Val Thr Asn Leu Gln Val
        35                  40                  45              
Met Arg Ala Met Ala Ser Leu Arg Ala Arg Gly Leu Val Arg Glu Thr
    50                  55                  60                  
Phe Ala Trp Cys His Phe Tyr Trp Tyr Leu Thr Asn Glu Gly Ile Ala
65                  70                  75                  80  
His Leu Arg Gln Tyr Leu His Leu Pro Pro Glu Ile Val Pro Ala Ser
                85                  90                  95      
Leu Gln Arg Val Arg Arg Pro Val Ala Met Val Met Pro Ala Arg Arg
            100                 105                 110         
Thr Pro His Val Gln Ala Val Gln Gly Pro Leu Gly Ser Pro Pro Lys
        115                 120                 125             
Arg Gly Pro Leu Pro Thr Glu Glu Gln Arg Val Tyr Arg Arg Lys Glu
    130                 135                 140                 
Leu Glu Glu Val Ser Pro Glu Thr Pro Val Val Pro Ala Thr Thr Gln
145                 150                 155                 160 
Arg Thr Leu Ala Arg Pro Gly Pro Glu Pro Ala Pro Ala Thr Asp Glu
                165                 170                 175     
Arg Asp Arg Val Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His
            180                 185                 190         
Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp Leu Arg
        195                 200                 205             
Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Ser
    210                 215                 220                 
Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln Asn Val
225                 230                 235                 240 
Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu Val Asn
                245                 250                 255     
Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr Leu Gly
            260                 265                 270         
Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile Gln Val
        275                 280                 285             
Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu Leu Trp
    290                 295                 300                 
Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp Asn Phe
305                 310                 315                 320 
Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile His Arg
                325                 330                 335     
His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln Thr Asn
            340                 345                 350         
Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp Leu Gly
        355                 360                 365             
Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln Pro Asp
    370                 375                 380                 
Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Met Pro
385                 390                 395                 400 
Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu Gln Leu
                405                 410                 415     
Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp Met
            420                 425                 430         
Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser Phe
        435                 440                 445             
Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu Met
    450                 455                 460                 
Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile Tyr
465                 470                 475                 480 
Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro Pro
                485                 490                 495     
Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His Val
            500                 505                 510         
Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg Leu
        515                 520                 525             
Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly Leu
    530                 535                 540                 
Cys Glu Glu Gln Leu Asn Gln Ala Asp Ala Leu Leu Gln Ser Asp Val
545                 550                 555                 560 
Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val Glu
                565                 570                 575     
Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn Asp
            580                 585                 590         
Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met Tyr
        595                 600                 605             
Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr Glu
    610                 615                 620                 
Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln Val
625                 630                 635                 640 
Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu Asp
                645                 650                 655     
Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu Asn
            660                 665                 670         
Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser Val
        675                 680                 685             
Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu Glu
    690                 695                 700                 
Phe Arg Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu Ser
705                 710                 715                 720 
Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp Leu
                725                 730                 735     
Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser Leu
            740                 745                 750         
Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met Trp
        755                 760                 765             
Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp Arg
    770                 775                 780                 
Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met Arg
785                 790                 795                 800 
Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala Gly
                805                 810                 815     
Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu Ser
            820                 825                 830         
Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys
        835                 840                 845             
Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe
    850                 855                 860                 
Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu
865                 870                 875                 880 
Ala Leu Arg Arg Lys Tyr Ser Cys Asp Arg Ser Ala Thr Val Thr Arg
                885                 890                 895     
Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn
            900                 905                 910         
Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val
        915                 920                 925             
Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu
    930                 935                 940                 
Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His
945                 950                 955                 960 
Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp
                965                 970                 975     
Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys
            980                 985                 990         
Phe Leu Val Pro Pro Pro Asn Gln Glu Ala Gln Glu Ala Val Thr Arg
        995                 1000                1005            
Leu Glu Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln Leu His
    1010                1015                1020                
Val Asp Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg Asp Val
1025                1030                1035                1040
Gln Leu Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr Leu Lys Pro
                1045                1050                1055    
Glu Glu Gln Arg Gln Ala Leu His Ser Leu Glu Leu His Tyr Gln Ala
            1060                1065                1070        
Phe Leu Arg Asp Ser Gln Asp Ala Gly Gly Phe Gly Pro Glu Asp Arg
        1075                1080                1085            
Leu Met Ala Glu Arg Glu Tyr Gly Ser Cys Ser His His Tyr Gln Gln
    1090                1095                1100                
Leu Leu Gln Ser Leu Glu Gln Gly Ala Gln Glu Glu Ser Arg Cys Gln
1105                1110                1115                1120
Arg Cys Ile Ser Glu Leu Lys Asp Ile Arg Leu Gln Leu Glu Ala Cys
                1125                1130                1135    
Glu Thr Arg Thr Val His Arg Leu Arg Leu Pro Leu Asp Lys Glu Pro
            1140                1145                1150        
Ala Arg Glu Cys Ala Gln Arg Ile Ala Glu Gln Gln Ala Gly Ala Lys
        1155                1160                1165            
Ala Gln Ala Glu Val Glu Gly Leu Gly Lys Gly Val Ala Arg Leu Ser
    1170                1175                1180                
Ala Glu Ala Glu Lys Val Leu Ala Leu Pro Glu Pro Ser Pro Ala Ala
1185                1190                1195                1200
Pro Thr Leu Arg Ser Glu Leu Glu Leu Thr Leu Gly Lys Leu Glu Gln
                1205                1210                1215    
Val Arg Ser Leu Ser Ala Ile Tyr Leu Glu Lys Leu Lys Thr Ile Ser
            1220                1225                1230        
Leu Val Ile Arg Gly Thr Gln Gly Ala Glu Glu Val Leu Arg Ala His
        1235                1240                1245            
Glu Glu Gln Leu Lys Glu Ala Gln Ala Val Pro Ala Thr Leu Pro Glu
    1250                1255                1260                
Leu Glu Ala Thr Lys Ala Ser Leu Lys Lys Leu Arg Ala Gln Ala Glu
1265                1270                1275                1280
Ala Gln Gln Pro Thr Phe Asp Ala Leu Arg Asp Glu Leu Arg Gly Ala
                1285                1290                1295    
Gln Glu Val Gly Glu Arg Leu Gln Gln Arg His Gly Glu Arg Asp Val
            1300                1305                1310        
Glu Val Glu Arg Trp Arg Glu Arg Val Ala Gln Leu Leu Glu Arg Trp
        1315                1320                1325            
Gln Ala Val Leu Ala Gln Thr Asp Val Arg Gln Arg Glu Leu Glu Gln
    1330                1335                1340                
Leu Gly Arg Gln Leu Arg Tyr Tyr Arg Glu Ser Ala Asp Pro Leu Gly
1345                1350                1355                1360
Ala Trp Leu Gln Asp Ala Arg Arg Arg Gln Glu Gln Ile Gln Ala Met
                1365                1370                1375    
Pro Leu Ala Asp Ser Gln Ala Val Arg Glu Gln Leu Arg Gln Glu Gln
            1380                1385                1390        
Ala Leu Leu Glu Glu Ile Glu Arg His Gly Glu Lys Val Glu Glu Cys
        1395                1400                1405            
Gln Arg Phe Ala Lys Gln Tyr Ile Asn Ala Ile Lys Asp Tyr Glu Leu
    1410                1415                1420                
Gln Leu Val Thr Tyr Lys Ala Gln Leu Glu Pro Val Ala Ser Pro Ala
1425                1430                1435                1440
Lys Lys Pro Lys Val Gln Ser Gly Ser Glu Ser Val Ile Gln Glu Tyr
                1445                1450                1455    
Val Asp Leu Arg Thr His Tyr Ser Glu Leu Thr Thr Leu Thr Ser Gln
            1460                1465                1470        
Tyr Ile Lys Phe Ile Ser Glu Thr Leu Arg Arg Met Glu Glu Glu Glu
        1475                1480                1485            
Arg Leu Ala Glu Gln Gln Arg Ala Glu Glu Arg Glu Arg Leu Ala Glu
    1490                1495                1500                
Val Glu Ala Ala Leu Glu Lys Gln Arg Gln Leu Ala Glu Ala His Ala
1505                1510                1515                1520
Gln Ala Lys Ala Gln Ala Glu Arg Glu Ala Lys Glu Leu Gln Gln Arg
                1525                1530                1535    
Met Gln Glu Glu Val Val Arg Arg Glu Glu Ala Ala Val Asp Ala Gln
            1540                1545                1550        
Gln Gln Lys Arg Ser Ile Gln Glu Glu Leu Gln Gln Leu Arg Gln Ser
        1555                1560                1565            
Ser Glu Ala Glu Ile Gln Ala Lys Ala Arg Gln Ala Glu Ala Ala Glu
    1570                1575                1580                
Arg Ser Arg Leu Arg Ile Glu Glu Glu Ile Arg Val Val Arg Leu Gln
1585                1590                1595                1600
Leu Glu Ala Thr Glu Arg Gln Arg Gly Gly Ala Glu Gly Glu Leu Gln
                1605                1610                1615    
Ala Leu Arg Ala Arg Ala Glu Glu Ala Glu Ala Gln Lys Arg Gln Ala
            1620                1625                1630        
Gln Glu Glu Ala Glu Arg Leu Arg Arg Gln Val Gln Asp Glu Ser Gln
        1635                1640                1645            
Arg Lys Arg Gln Ala Glu Val Glu Leu Ala Ser Arg Val Lys Ala Glu
    1650                1655                1660                
Ala Glu Ala Ala Arg Glu Lys Gln Arg Ala Leu Gln Ala Leu Glu Glu
1665                1670                1675                1680
Leu Arg Leu Gln Ala Glu Glu Ala Glu Arg Arg Leu Arg Gln Ala Glu
                1685                1690                1695    
Val Glu Arg Ala Arg Gln Val Gln Val Ala Leu Glu Thr Ala Gln Arg
            1700                1705                1710        
Ser Ala Glu Ala Glu Leu Gln Ser Lys Arg Ala Ser Phe Ala Glu Lys
        1715                1720                1725            
Thr Ala Gln Leu Glu Arg Ser Leu Gln Glu Glu His Val Ala Val Ala
    1730                1735                1740                
Gln Leu Arg Glu Glu Ala Glu Arg Arg Ala Gln Gln Gln Ala Glu Ala
1745                1750                1755                1760
Glu Arg Ala Arg Glu Glu Ala Glu Arg Glu Leu Glu Arg Trp Gln Leu
                1765                1770                1775    
Lys Ala Asn Glu Ala Leu Arg Leu Arg Leu Gln Ala Glu Glu Val Ala
            1780                1785                1790        
Gln Gln Lys Ser Leu Ala Gln Ala Glu Ala Glu Lys Gln Lys Glu Glu
        1795                1800                1805            
Ala Glu Arg Glu Ala Arg Arg Arg Gly Lys Ala Glu Glu Gln Ala Val
    1810                1815                1820                
Arg Gln Arg Glu Leu Ala Glu Gln Glu Leu Glu Lys Gln Arg Gln Leu
1825                1830                1835                1840
Ala Glu Gly Thr Ala Gln Gln Arg Leu Ala Ala Glu Gln Glu Leu Ile
                1845                1850                1855    
Arg Leu Arg Ala Glu Thr Glu Gln Gly Glu Gln Gln Arg Gln Leu Leu
            1860                1865                1870        
Glu Glu Glu Leu Ala Arg Leu Gln Arg Glu Ala Ala Ala Ala Thr Gln
        1875                1880                1885            
Lys Arg Gln Glu Leu Glu Ala Glu Leu Ala Lys Val Arg Ala Glu Met
    1890                1895                1900                
Glu Val Leu Leu Ala Ser Lys Ala Arg Ala Glu Glu Glu Ser Arg Ser
1905                1910                1915                1920
Thr Ser Glu Lys Ser Lys Gln Arg Leu Glu Ala Glu Ala Gly Arg Phe
                1925                1930                1935    
Arg Glu Leu Ala Glu Glu Ala Ala Arg Leu Arg Ala Leu Ala Glu Glu
            1940                1945                1950        
Ala Lys Arg Gln Arg Gln Leu Ala Glu Glu Asp Ala Ala Arg Gln Arg
        1955                1960                1965            
Ala Glu Ala Glu Arg Val Leu Ala Glu Lys Leu Ala Ala Ile Gly Glu
    1970                1975                1980                
Ala Thr Arg Leu Lys Thr Glu Ala Glu Ile Ala Leu Lys Glu Lys Glu
1985                1990                1995                2000
Ala Glu Asn Glu Arg Leu Arg Arg Leu Ala Glu Asp Glu Ala Phe Gln
                2005                2010                2015    
Arg Arg Arg Leu Glu Glu Gln Ala Ala Gln His Lys Ala Asp Ile Glu
            2020                2025                2030        
Glu Arg Leu Ala Gln Leu Arg Lys Ala Ser Asp Ser Glu Leu Glu Arg
        2035                2040                2045            
Gln Lys Gly Leu Val Glu Asp Thr Leu Arg Gln Arg Arg Gln Val Glu
    2050                2055                2060                
Glu Glu Ile Leu Ala Leu Lys Ala Ser Phe Glu Lys Ala Ala Ala Gly
2065                2070                2075                2080
Lys Ala Glu Leu Glu Leu Glu Leu Gly Arg Ile Arg Ser Asn Ala Glu
                2085                2090                2095    
Asp Thr Leu Arg Ser Lys Glu Gln Ala Glu Leu Glu Ala Ala Arg Gln
            2100                2105                2110        
Arg Gln Leu Ala Ala Glu Glu Glu Arg Arg Arg Arg Glu Ala Glu Glu
        2115                2120                2125            
Arg Val Gln Lys Ser Leu Ala Ala Glu Glu Glu Ala Ala Arg Gln Arg
    2130                2135                2140                
Lys Ala Ala Leu Glu Glu Val Glu Arg Leu Lys Ala Lys Val Glu Glu
2145                2150                2155                2160
Ala Arg Arg Leu Arg Glu Arg Ala Glu Gln Glu Ser Ala Arg Gln Leu
                2165                2170                2175    
Gln Leu Ala Gln Glu Ala Ala Gln Lys Arg Leu Gln Ala Glu Glu Lys
            2180                2185                2190        
Ala His Ala Phe Ala Val Gln Gln Lys Glu Gln Glu Leu Gln Gln Thr
        2195                2200                2205            
Leu Gln Gln Glu Gln Ser Val Leu Asp Gln Leu Arg Gly Glu Ala Glu
    2210                2215                2220                
Ala Ala Arg Arg Ala Ala Glu Glu Ala Glu Glu Ala Arg Val Gln Ala
2225                2230                2235                2240
Glu Arg Glu Ala Ala Gln Ser Arg Arg Gln Val Glu Glu Ala Glu Arg
                2245                2250                2255    
Leu Lys Gln Ser Ala Glu Glu Gln Ala Gln Ala Arg Ala Gln Ala Gln
            2260                2265                2270        
Ala Ala Ala Glu Lys Leu Arg Lys Glu Ala Glu Gln Glu Ala Ala Arg
        2275                2280                2285            
Arg Ala Gln Ala Glu Gln Ala Ala Leu Arg Gln Lys Gln Ala Ala Asp
    2290                2295                2300                
Ala Glu Met Glu Lys His Lys Lys Phe Ala Glu Gln Thr Leu Arg Gln
2305                2310                2315                2320
Lys Ala Gln Val Glu Gln Glu Leu Thr Thr Leu Arg Leu Gln Leu Glu
                2325                2330                2335    
Glu Thr Asp His Gln Lys Asn Leu Leu Asp Glu Glu Leu Gln Arg Leu
            2340                2345                2350        
Lys Ala Glu Ala Thr Glu Ala Ala Arg Gln Arg Ser Gln Val Glu Glu
        2355                2360                2365            
Glu Leu Phe Ser Val Arg Val Gln Met Glu Glu Leu Ser Lys Leu Lys
    2370                2375                2380                
Ala Arg Ile Glu Ala Glu Asn Arg Ala Leu Ile Leu Arg Asp Lys Asp
2385                2390                2395                2400
Asn Thr Gln Arg Phe Leu Gln Glu Glu Ala Glu Lys Met Lys Gln Val
                2405                2410                2415    
Ala Glu Glu Ala Ala Arg Leu Ser Val Ala Ala Gln Glu Ala Ala Arg
            2420                2425                2430        
Leu Arg Gln Leu Ala Glu Glu Asp Leu Ala Gln Gln Arg Ala Leu Ala
        2435                2440                2445            
Glu Lys Met Leu Lys Glu Lys Met Gln Ala Val Gln Glu Ala Thr Arg
    2450                2455                2460                
Leu Lys Ala Glu Ala Glu Leu Leu Gln Gln Gln Lys Glu Leu Ala Gln
2465                2470                2475                2480
Glu Gln Ala Arg Arg Leu Gln Glu Asp Lys Glu Gln Met Ala Gln Gln
                2485                2490                2495    
Leu Ala Glu Glu Thr Gln Gly Phe Gln Arg Thr Leu Glu Ala Glu Arg
            2500                2505                2510        
Gln Arg Gln Leu Glu Met Ser Ala Glu Ala Glu Arg Leu Lys Leu Arg
        2515                2520                2525            
Val Ala Glu Met Ser Arg Ala Gln Ala Arg Ala Glu Glu Asp Ala Gln
    2530                2535                2540                
Arg Phe Arg Lys Gln Ala Glu Glu Ile Gly Glu Lys Leu His Arg Thr
2545                2550                2555                2560
Glu Leu Ala Thr Gln Glu Lys Val Thr Leu Val Gln Thr Leu Glu Ile
                2565                2570                2575    
Gln Arg Gln Gln Ser Asp His Asp Ala Glu Arg Leu Arg Glu Ala Ile
            2580                2585                2590        
Ala Glu Leu Glu Arg Glu Lys Glu Lys Leu Gln Gln Glu Ala Lys Leu
        2595                2600                2605            
Leu Gln Leu Lys Ser Glu Glu Met Gln Thr Val Gln Gln Glu Gln Leu
    2610                2615                2620                
Leu Gln Glu Thr Gln Ala Leu Gln Gln Ser Phe Leu Ser Glu Lys Asp
2625                2630                2635                2640
Ser Leu Leu Gln Arg Glu Arg Phe Ile Glu Gln Glu Lys Ala Lys Leu
                2645                2650                2655    
Glu Gln Leu Phe Gln Asp Glu Val Ala Lys Ala Gln Gln Leu Arg Glu
            2660                2665                2670        
Glu Gln Gln Arg Gln Gln Gln Gln Met Glu Gln Glu Arg Gln Arg Leu
        2675                2680                2685            
Val Ala Ser Met Glu Glu Ala Arg Arg Arg Gln His Glu Ala Glu Glu
    2690                2695                2700                
Gly Val Arg Arg Lys Gln Glu Glu Leu Gln Gln Leu Glu Gln Gln Arg
2705                2710                2715                2720
Arg Gln Gln Glu Glu Leu Leu Ala Glu Glu Asn Gln Arg Leu Arg Glu
                2725                2730                2735    
Gln Leu Gln Leu Leu Glu Glu Gln His Arg Ala Ala Leu Ala His Ser
            2740                2745                2750        
Glu Glu Val Thr Ala Ser Gln Val Ala Ala Thr Lys Thr Leu Pro Asn
        2755                2760                2765            
Gly Arg Asp Ala Leu Asp Gly Pro Ala Ala Glu Ala Glu Pro Glu His
    2770                2775                2780                
Ser Phe Asp Gly Leu Arg Arg Lys Val Ser Ala Gln Arg Leu Gln Glu
2785                2790                2795                2800
Ala Gly Ile Leu Ser Ala Glu Glu Leu Gln Arg Leu Ala Gln Gly His
                2805                2810                2815    
Thr Thr Val Asp Glu Leu Ala Arg Arg Glu Asp Val Arg His Tyr Leu
            2820                2825                2830        
Gln Gly Arg Ser Ser Ile Ala Gly Leu Leu Leu Lys Ala Thr Asn Glu
        2835                2840                2845            
Lys Leu Ser Val Tyr Ala Ala Leu Gln Arg Gln Leu Leu Ser Pro Gly
    2850                2855                2860                
Thr Ala Leu Ile Leu Leu Glu Ala Gln Ala Ala Ser Gly Phe Leu Leu
2865                2870                2875                2880
Asp Pro Val Arg Asn Arg Arg Leu Thr Val Asn Glu Ala Val Lys Glu
                2885                2890                2895    
Gly Val Val Gly Pro Glu Leu His His Lys Leu Leu Ser Ala Glu Arg
            2900                2905                2910        
Ala Val Thr Gly Tyr Lys Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu
        2915                2920                2925            
Phe Gln Ala Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg
    2930                2935                2940                
Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His
2945                2950                2955                2960
Ser His Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp
                2965                2970                2975    
Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly
            2980                2985                2990        
Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln Leu Leu
        2995                3000                3005            
Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Cys Leu Leu Pro Leu
    3010                3015                3020                
Thr Asp Lys Ala Ala Lys Gly Gly Glu Leu Val Tyr Thr Asp Ser Glu
3025                3030                3035                3040
Ala Arg Asp Val Phe Glu Lys Ala Thr Val Ser Ala Pro Phe Gly Lys
                3045                3050                3055    
Phe Gln Gly Lys Thr Val Thr Ile Trp Glu Ile Ile Asn Ser Glu Tyr
            3060                3065                3070        
Phe Thr Ala Glu Gln Arg Arg Asp Leu Leu Arg Gln Phe Arg Thr Gly
        3075                3080                3085            
Arg Ile Thr Val Glu Lys Ile Ile Lys Ile Ile Ile Thr Val Val Glu
    3090                3095                3100                
Glu Gln Glu Gln Lys Gly Arg Leu Cys Phe Glu Gly Leu Arg Ser Leu
3105                3110                3115                3120
Val Pro Ala Ala Glu Leu Leu Glu Ser Arg Val Ile Asp Arg Glu Leu
                3125                3130                3135    
Tyr Gln Gln Leu Gln Arg Gly Glu Arg Ser Val Arg Asp Val Ala Glu
            3140                3145                3150        
Val Asp Thr Val Arg Arg Ala Leu Arg Gly Ala Asn Val Ile Ala Gly
        3155                3160                3165            
Val Trp Leu Glu Glu Ala Gly Gln Lys Leu Ser Ile Tyr Asn Ala Leu
    3170                3175                3180                
Lys Lys Asp Leu Leu Pro Ser Asp Met Ala Val Ala Leu Leu Glu Ala
3185                3190                3195                3200
Gln Ala Gly Thr Gly His Ile Ile Asp Pro Ala Thr Ser Ala Arg Leu
                3205                3210                3215    
Thr Val Asp Glu Ala Val Arg Ala Gly Leu Val Gly Pro Glu Phe His
            3220                3225                3230        
Glu Lys Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr Arg Asp Pro
        3235                3240                3245            
Tyr Thr Gly Gln Ser Val Ser Leu Phe Gln Ala Leu Lys Lys Gly Leu
    3250                3255                3260                
Ile Pro Arg Glu Gln Gly Leu Arg Leu Leu Asp Ala Gln Leu Ser Thr
3265                3270                3275                3280
Gly Gly Ile Val Asp Pro Ser Lys Ser His Arg Val Pro Leu Asp Val
                3285                3290                3295    
Ala Cys Ala Arg Gly Cys Leu Asp Glu Glu Thr Ser Arg Ala Leu Ser
            3300                3305                3310        
Ala Pro Arg Ala Asp Ala Lys Ala Tyr Ser Asp Pro Ser Thr Gly Glu
        3315                3320                3325            
Pro Ala Thr Tyr Gly Glu Leu Gln Gln Arg Cys Arg Pro Asp Gln Leu
    3330                3335                3340                
Thr Gly Leu Ser Leu Leu Pro Leu Ser Glu Lys Ala Ala Arg Ala Arg
3345                3350                3355                3360
Gln Glu Glu Leu Tyr Ser Glu Leu Gln Ala Arg Glu Thr Phe Glu Lys
                3365                3370                3375    
Thr Pro Val Glu Val Pro Val Gly Gly Phe Lys Gly Arg Thr Val Thr
            3380                3385                3390        
Val Trp Glu Leu Ile Ser Ser Glu Tyr Phe Thr Ala Glu Gln Arg Gln
        3395                3400                3405            
Glu Leu Leu Arg Gln Phe Arg Thr Gly Lys Val Thr Val Glu Lys Val
    3410                3415                3420                
Ile Lys Ile Leu Ile Thr Ile Val Glu Glu Val Glu Thr Leu Arg Gln
3425                3430                3435                3440
Glu Arg Leu Ser Phe Ser Gly Leu Arg Ala Pro Val Pro Ala Ser Glu
                3445                3450                3455    
Leu Leu Ala Ser Gly Val Leu Ser Arg Ala Gln Phe Glu Gln Leu Lys
            3460                3465                3470        
Asp Gly Lys Thr Thr Val Lys Asp Leu Ser Glu Leu Gly Ser Val Arg
        3475                3480                3485            
Thr Leu Leu Gln Gly Ser Gly Cys Leu Ala Gly Ile Tyr Leu Glu Asp
    3490                3495                3500                
Thr Lys Glu Lys Val Ser Ile Tyr Glu Ala Met Arg Arg Gly Leu Leu
3505                3510                3515                3520
Arg Ala Thr Thr Ala Ala Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly
                3525                3530                3535    
Phe Leu Val Asp Pro Val Arg Asn Gln Arg Leu Tyr Val His Glu Ala
            3540                3545                3550        
Val Lys Ala Gly Val Val Gly Pro Glu Leu His Glu Gln Leu Leu Ser
        3555                3560                3565            
Ala Glu Lys Ala Val Thr Gly Tyr Arg Asp Pro Tyr Ser Gly Ser Thr
    3570                3575                3580                
Ile Ser Leu Phe Gln Ala Met Gln Lys Gly Leu Val Leu Arg Gln His
3585                3590                3595                3600
Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp
                3605                3610                3615    
Pro Val His Ser His Arg Val Pro Val Asp Val Ala Tyr Gln Arg Gly
            3620                3625                3630        
Tyr Phe Ser Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp
        3635                3640                3645            
Thr Lys Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Arg
    3650                3655                3660                
Gln Leu Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Arg Leu
3665                3670                3675                3680
Leu Pro Leu Lys Gly Ala Glu Lys Ala Glu Val Val Glu Thr Thr Gln
                3685                3690                3695    
Val Tyr Thr Glu Glu Glu Thr Arg Arg Ala Phe Glu Glu Thr Gln Ile
            3700                3705                3710        
Asp Ile Pro Gly Gly Gly Ser His Gly Gly Ser Thr Met Ser Leu Trp
        3715                3720                3725            
Glu Val Met Gln Ser Asp Leu Ile Pro Glu Glu Gln Arg Ala Gln Leu
    3730                3735                3740                
Met Ala Asp Phe Gln Ala Gly Arg Val Thr Lys Glu Arg Met Ile Ile
3745                3750                3755                3760
Ile Ile Ile Glu Ile Ile Glu Lys Thr Glu Ile Ile Arg Gln Gln Gly
                3765                3770                3775    
Leu Ala Ser Tyr Asp Tyr Val Arg Arg Arg Leu Thr Ala Glu Asp Leu
            3780                3785                3790        
Phe Glu Ala Arg Ile Ile Ser Leu Glu Thr Tyr Asn Leu Leu Arg Glu
        3795                3800                3805            
Gly Thr Arg Ser Leu Arg Glu Ala Leu Glu Ala Glu Ser Ala Trp Cys
    3810                3815                3820                
Tyr Leu Tyr Gly Thr Gly Ser Val Ala Gly Val Tyr Leu Pro Gly Ser
3825                3830                3835                3840
Arg Gln Thr Leu Ser Ile Tyr Gln Ala Leu Lys Lys Gly Leu Leu Ser
                3845                3850                3855    
Ala Glu Val Ala Arg Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe
            3860                3865                3870        
Leu Leu Asp Pro Val Lys Gly Glu Arg Leu Thr Val Asp Glu Ala Val
        3875                3880                3885            
Arg Lys Gly Leu Val Gly Pro Glu Leu His Asp Arg Leu Leu Ser Ala
    3890                3895                3900                
Glu Arg Ala Val Thr Gly Tyr Arg Asp Pro Tyr Thr Glu Gln Thr Ile
3905                3910                3915                3920
Ser Leu Phe Gln Ala Met Lys Lys Glu Leu Ile Pro Thr Glu Glu Ala
                3925                3930                3935    
Leu Arg Leu Leu Asp Ala Gln Leu Ala Thr Gly Gly Ile Val Asp Pro
            3940                3945                3950        
Arg Leu Gly Phe His Leu Pro Leu Glu Val Ala Tyr Gln Arg Gly Tyr
        3955                3960                3965            
Leu Asn Lys Asp Thr His Asp Gln Leu Ser Glu Pro Ser Glu Val Arg
    3970                3975                3980                
Ser Tyr Val Asp Pro Ser Thr Asp Glu Arg Leu Ser Tyr Thr Gln Leu
3985                3990                3995                4000
Leu Arg Arg Cys Arg Arg Asp Asp Gly Thr Gly Gln Leu Leu Leu Pro
                4005                4010                4015    
Leu Ser Asp Ala Arg Lys Leu Thr Phe Arg Gly Leu Arg Lys Gln Ile
            4020                4025                4030        
Thr Met Glu Glu Leu Val Arg Ser Gln Val Met Asp Glu Ala Thr Ala
        4035                4040                4045            
Leu Gln Leu Arg Glu Gly Leu Thr Ser Ile Glu Glu Val Thr Lys Asn
    4050                4055                4060                
Leu Gln Lys Phe Leu Glu Gly Thr Ser Cys Ile Ala Gly Val Phe Val
4065                4070                4075                4080
Asp Ala Thr Lys Glu Arg Leu Ser Val Tyr Gln Ala Met Lys Lys Gly
                4085                4090                4095    
Ile Ile Arg Pro Gly Thr Ala Phe Glu Leu Leu Glu Ala Gln Ala Ala
            4100                4105                4110        
Thr Gly Tyr Val Ile Asp Pro Ile Lys Gly Leu Lys Leu Thr Val Glu
        4115                4120                4125            
Glu Ala Val Arg Met Gly Ile Val Gly Pro Glu Phe Lys Asp Lys Leu
    4130                4135                4140                
Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr Lys Asp Pro Tyr Ser Gly
4145                4150                4155                4160
Lys Leu Ile Ser Leu Phe Gln Ala Met Lys Lys Gly Leu Ile Leu Lys
                4165                4170                4175    
Asp His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Ile
            4180                4185                4190        
Ile Asp Pro Glu Glu Ser His Arg Leu Pro Val Glu Val Ala Tyr Lys
        4195                4200                4205            
Arg Gly Leu Phe Asp Glu Glu Met Asn Glu Ile Leu Thr Asp Pro Ser
    4210                4215                4220                
Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr Glu Glu Asn Leu Thr
4225                4230                4235                4240
Tyr Leu Gln Leu Met Glu Arg Cys Ile Thr Asp Pro Gln Thr Gly Leu
                4245                4250                4255    
Cys Leu Leu Pro Leu Lys Glu Lys Lys Arg Glu Arg Lys Thr Ser Ser
            4260                4265                4270        
Lys Ser Ser Val Arg Lys Arg Arg Val Val Ile Val Asp Pro Glu Thr
        4275                4280                4285            
Gly Lys Glu Met Ser Val Tyr Glu Ala Tyr Arg Lys Gly Leu Ile Asp
    4290                4295                4300                
His Gln Thr Tyr Leu Glu Leu Ser Glu Gln Glu Cys Glu Trp Glu Glu
4305                4310                4315                4320
Ile Thr Ile Ser Ser Ser Asp Gly Val Val Lys Ser Met Ile Ile Asp
                4325                4330                4335    
Arg Arg Ser Gly Arg Gln Tyr Asp Ile Asp Asp Ala Ile Ala Lys Asn
            4340                4345                4350        
Leu Ile Asp Arg Ser Ala Leu Asp Gln Tyr Arg Ala Gly Thr Leu Ser
        4355                4360                4365            
Ile Thr Glu Phe Ala Asp Met Leu Ser Gly Asn Ala Gly Gly Phe Arg
    4370                4375                4380                
Ser Arg Ser Ser Ser Val Gly Ser Ser Ser Ser Tyr Pro Ile Ser Pro
4385                4390                4395                4400
Ala Val Ser Arg Thr Gln Leu Ala Ser Trp Ser Asp Pro Thr Glu Glu
                4405                4410                4415    
Thr Gly Pro Val Ala Gly Ile Leu Asp Thr Glu Thr Leu Glu Lys Val
            4420                4425                4430        
Ser Ile Thr Glu Ala Met His Arg Asn Leu Val Asp Asn Ile Thr Gly
        4435                4440                4445            
Gln Arg Leu Leu Glu Ala Gln Ala Cys Thr Gly Gly Ile Ile Asp Pro
    4450                4455                4460                
Ser Thr Gly Glu Arg Phe Pro Val Thr Asp Ala Val Asn Lys Gly Leu
4465                4470                4475                4480
Val Asp Lys Ile Met Val Asp Arg Ile Asn Leu Ala Gln Lys Ala Phe
                4485                4490                4495    
Cys Gly Phe Glu Asp Pro Arg Thr Lys Thr Lys Met Ser Ala Ala Gln
            4500                4505                4510        
Ala Leu Lys Lys Gly Trp Leu Tyr Tyr Glu Ala Gly Gln Arg Phe Leu
        4515                4520                4525            
Glu Val Gln Tyr Leu Thr Gly Gly Leu Ile Glu Pro Asp Thr Pro Gly
    4530                4535                4540                
Arg Val Pro Leu Asp Glu Ala Leu Gln Arg Gly Thr Val Asp Ala Arg
4545                4550                4555                4560
Thr Ala Gln Lys Leu Arg Asp Val Gly Ala Tyr Ser Lys Tyr Leu Thr
                4565                4570                4575    
Cys Pro Lys Thr Lys Leu Lys Ile Ser Tyr Lys Asp Ala Leu Asp Arg
            4580                4585                4590        
Ser Met Val Glu Glu Gly Thr Gly Leu Arg Leu Leu Glu Ala Ala Ala
        4595                4600                4605            
Gln Ser Thr Lys Gly Tyr Tyr Ser Pro Tyr Ser Val Ser Gly Ser Gly
    4610                4615                4620                
Ser Thr Ala Gly Ser Arg Thr Gly Ser Arg Thr Gly Ser Arg Ala Gly
4625                4630                4635                4640
Ser Arg Arg Gly Ser Phe Asp Ala Thr Gly Ser Gly Phe Ser Met Thr
                4645                4650                4655    
Phe Ser Ser Ser Ser Tyr Ser Ser Ser Gly Tyr Gly Arg Arg Tyr Ala
            4660                4665                4670        
Ser Gly Ser Ser Ala Ser Leu Gly Gly Pro Glu Ser Ala Val Ala
        4675                4680                4685        


<210> 7787
<211> 4574
<212> PRT
<213> Homo sapiens

<400> 7787
Met Ser Gly Glu Asp Ala Glu Val Arg Ala Val Ser Glu Asp Val Ser
 1               5                  10                  15      
Asn Gly Ser Ser Gly Ser Pro Ser Pro Gly Asp Thr Leu Pro Trp Asn
            20                  25                  30          
Leu Gly Lys Thr Gln Arg Ser Arg Arg Ser Gly Gly Gly Ala Gly Ser
        35                  40                  45              
Asn Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Ile Arg Ile Ala
    50                  55                  60                  
Asp Glu Arg Asp Arg Val Gln Lys Lys Thr Ser Thr Lys Trp Val Asn
65                  70                  75                  80  
Lys His Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp
                85                  90                  95      
Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly
            100                 105                 110         
Asp Ser Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln
        115                 120                 125             
Asn Val Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu
    130                 135                 140                 
Val Asn Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr
145                 150                 155                 160 
Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile
                165                 170                 175     
Gln Val Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu
            180                 185                 190         
Leu Trp Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp
        195                 200                 205             
Asn Phe Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile
    210                 215                 220                 
His Arg His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln
225                 230                 235                 240 
Thr Asn Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp
                245                 250                 255     
Leu Gly Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln
            260                 265                 270         
Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala
        275                 280                 285             
Met Pro Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu
    290                 295                 300                 
Gln Leu Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln
305                 310                 315                 320 
Trp Met Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser
                325                 330                 335     
Ser Phe Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys
            340                 345                 350         
Glu Met Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly
        355                 360                 365             
Ile Tyr Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val
    370                 375                 380                 
Pro Pro Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu
385                 390                 395                 400 
His Val Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu
                405                 410                 415     
Arg Leu Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala
            420                 425                 430         
Gly Leu Cys Glu Glu Gln Leu His Gln Ala Asp Ala Leu Leu Gln Ser
        435                 440                 445             
Asp Ile Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu
    450                 455                 460                 
Val Glu Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe
465                 470                 475                 480 
Asn Asp Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln
                485                 490                 495     
Met Tyr Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg
            500                 505                 510         
Thr Glu Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr
        515                 520                 525             
Gln Val Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu
    530                 535                 540                 
Glu Asp Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu
545                 550                 555                 560 
Glu Asn Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro
                565                 570                 575     
Ser Val Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile
            580                 585                 590         
Glu Glu Phe Gln Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln
        595                 600                 605             
Leu Ser Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu
    610                 615                 620                 
Asp Leu Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg
625                 630                 635                 640 
Ser Leu Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu
                645                 650                 655     
Met Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser
            660                 665                 670         
Asp Arg Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu
        675                 680                 685             
Met Arg Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn
    690                 695                 700                 
Ala Gly Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val
705                 710                 715                 720 
Glu Ser Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln
                725                 730                 735     
Leu Cys Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe
            740                 745                 750         
Gln Phe Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu
        755                 760                 765             
Gln Glu Ala Leu Arg Arg Lys Asn Ser Cys Asp Arg Ser Ala Thr Val
    770                 775                 780                 
Thr Arg Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln
785                 790                 795                 800 
Leu Asn Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys
                805                 810                 815     
Ala Val Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly
            820                 825                 830         
Arg Leu Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr
        835                 840                 845             
Val His Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser
    850                 855                 860                 
His Trp Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser
865                 870                 875                 880 
Val Cys Phe Leu Val Pro Pro Pro Asn Gln Glu Val Gln Glu Ala Val
                885                 890                 895     
Thr Arg Leu Glu Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln
            900                 905                 910         
Leu His Val Asp Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg
        915                 920                 925             
Asp Val Gln Leu Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr Leu
    930                 935                 940                 
Lys Pro Glu Glu Gln Arg Gln Ala Leu His Ser Leu Glu Leu His Tyr
945                 950                 955                 960 
Gln Ala Phe Leu Arg Asp Ser Gln Asp Ala Gly Gly Phe Gly Pro Glu
                965                 970                 975     
Asp Arg Leu Met Ala Glu Arg Glu Tyr Gly Ser Cys Ser His His Tyr
            980                 985                 990         
Gln Gln Leu Leu Gln Ser Leu Glu Gln Gly Ala Gln Glu Glu Ser Arg
        995                 1000                1005            
Cys Gln Arg Cys Ile Ser Glu Leu Lys Asp Ile Arg Leu Gln Leu Glu
    1010                1015                1020                
Ala Cys Glu Thr Arg Thr Val His Arg Leu Arg Leu Pro Leu Asp Lys
1025                1030                1035                1040
Glu Pro Ala Arg Glu Cys Ala Gln Arg Ile Ala Glu Gln Gln Lys Ala
                1045                1050                1055    
Gln Ala Glu Val Glu Gly Leu Gly Lys Gly Val Ala Arg Leu Ser Ala
            1060                1065                1070        
Glu Ala Glu Lys Val Leu Ala Leu Pro Glu Pro Ser Pro Ala Ala Pro
        1075                1080                1085            
Thr Leu Arg Ser Glu Leu Glu Leu Thr Leu Gly Lys Leu Glu Gln Val
    1090                1095                1100                
Arg Ser Leu Ser Ala Ile Tyr Leu Glu Lys Leu Lys Thr Ile Ser Leu
1105                1110                1115                1120
Val Ile Arg Gly Thr Gln Gly Ala Glu Glu Val Leu Arg Ala His Glu
                1125                1130                1135    
Glu Gln Leu Lys Glu Ala Gln Ala Val Pro Ala Thr Leu Pro Glu Leu
            1140                1145                1150        
Glu Ala Thr Lys Ala Ser Leu Lys Lys Leu Arg Ala Gln Ala Glu Ala
        1155                1160                1165            
Gln Gln Pro Thr Phe Asp Ala Leu Arg Asp Glu Leu Arg Gly Ala Gln
    1170                1175                1180                
Glu Val Gly Glu Arg Leu Gln Gln Arg His Gly Glu Arg Asp Val Glu
1185                1190                1195                1200
Val Glu Arg Trp Arg Glu Arg Val Ala Gln Leu Leu Glu Arg Trp Gln
                1205                1210                1215    
Ala Val Leu Ala Gln Thr Asp Val Arg Gln Arg Glu Leu Glu Gln Leu
            1220                1225                1230        
Gly Arg Gln Leu Arg Tyr Tyr Arg Glu Ser Ala Asp Pro Leu Gly Ala
        1235                1240                1245            
Trp Leu Gln Asp Ala Arg Arg Arg Gln Glu Gln Ile Gln Ala Met Pro
    1250                1255                1260                
Leu Ala Asp Ser Gln Ala Val Arg Glu Gln Leu Arg Gln Glu Gln Ala
1265                1270                1275                1280
Leu Leu Glu Glu Ile Glu Arg His Gly Glu Lys Val Glu Glu Cys Gln
                1285                1290                1295    
Arg Phe Ala Lys Gln Tyr Ile Asn Ala Ile Lys Asp Tyr Glu Leu Gln
            1300                1305                1310        
Leu Val Thr Tyr Lys Ala Gln Leu Glu Pro Val Ala Ser Pro Ala Lys
        1315                1320                1325            
Lys Pro Lys Val Gln Ser Gly Ser Glu Ser Val Ile Gln Glu Tyr Val
    1330                1335                1340                
Asp Leu Arg Thr His Tyr Ser Glu Leu Thr Thr Leu Thr Ser Gln Tyr
1345                1350                1355                1360
Ile Lys Phe Ile Ser Glu Thr Leu Arg Arg Met Glu Glu Glu Glu Arg
                1365                1370                1375    
Leu Ala Glu Gln Gln Arg Ala Glu Glu Arg Glu Arg Leu Ala Glu Val
            1380                1385                1390        
Glu Ala Ala Leu Glu Lys Gln Arg Gln Leu Ala Glu Ala His Ala Gln
        1395                1400                1405            
Ala Lys Ala Gln Ala Glu Arg Glu Ala Lys Glu Leu Gln Gln Arg Ile
    1410                1415                1420                
Gln Glu Glu Val Val Arg Arg Glu Glu Ala Ala Val Asp Ala Gln Gln
1425                1430                1435                1440
Gln Lys Arg Ser Ile Gln Glu Glu Leu Gln Gln Leu Arg Gln Ser Ser
                1445                1450                1455    
Glu Ala Glu Ile Gln Ala Lys Ala Arg Gln Ala Glu Ala Ala Glu Arg
            1460                1465                1470        
Ser Arg Leu Arg Ile Glu Glu Glu Ile Arg Val Val Arg Leu Gln Leu
        1475                1480                1485            
Glu Ala Thr Glu Arg Gln Arg Gly Gly Ala Glu Gly Glu Leu Gln Ala
    1490                1495                1500                
Leu Arg Ala Arg Ala Glu Glu Ala Glu Ala Gln Lys Arg Gln Ala Gln
1505                1510                1515                1520
Glu Glu Ala Glu Arg Leu Arg Arg Gln Val Gln Asp Glu Ser Gln Arg
                1525                1530                1535    
Lys Arg Gln Ala Glu Val Glu Leu Ala Ser Arg Val Lys Ala Glu Ala
            1540                1545                1550        
Glu Ala Ala Arg Glu Lys Gln Arg Ala Leu Gln Ala Leu Glu Glu Leu
        1555                1560                1565            
Arg Leu Gln Ala Glu Glu Ala Glu Arg Trp Leu Cys Gln Ala Glu Val
    1570                1575                1580                
Glu Arg Ala Arg Gln Val Gln Val Ala Leu Glu Thr Ala Gln Arg Ser
1585                1590                1595                1600
Ala Glu Ala Glu Leu Gln Ser Lys Arg Ala Ser Phe Ala Glu Lys Thr
                1605                1610                1615    
Ala Gln Leu Glu Arg Ser Leu Gln Glu Glu His Val Ala Val Ala Gln
            1620                1625                1630        
Leu Arg Glu Glu Ala Glu Arg Arg Ala Gln Gln Gln Ala Glu Ala Glu
        1635                1640                1645            
Arg Ala Arg Glu Glu Ala Glu Arg Gln Leu Glu Arg Trp Gln Leu Lys
    1650                1655                1660                
Ala Asn Glu Ala Leu Arg Leu Arg Leu Gln Ala Glu Glu Val Leu Gln
1665                1670                1675                1680
Gln Lys Ser Leu Ala Gln Ala Glu Ala Glu Lys Gln Lys Glu Glu Ala
                1685                1690                1695    
Glu Arg Glu Ala Arg Arg Arg Gly Lys Ala Glu Glu Gln Ala Val Arg
            1700                1705                1710        
Gln Arg Glu Leu Ala Glu Gln Glu Leu Glu Lys Gln Arg Gln Leu Ala
        1715                1720                1725            
Glu Gly Thr Ala Gln Gln Arg Leu Ala Ala Glu Gln Glu Leu Ile Arg
    1730                1735                1740                
Leu Arg Ala Glu Thr Glu Gln Gly Glu Gln Gln Arg Gln Leu Leu Glu
1745                1750                1755                1760
Glu Glu Leu Ala Arg Leu Gln Arg Glu Ala Ala Ala Ala Thr Gln Lys
                1765                1770                1775    
Arg Gln Glu Leu Glu Ala Glu Leu Ala Lys Val Arg Ala Glu Met Glu
            1780                1785                1790        
Val Leu Leu Ala Ser Lys Ala Lys Ala Glu Glu Glu Ser Arg Ser Thr
        1795                1800                1805            
Ser Glu Lys Ser Lys Gln Arg Leu Glu Ala Glu Ala Gly Arg Phe Arg
    1810                1815                1820                
Glu Leu Ala Glu Glu Ala Ala Arg Leu Arg Ala Leu Ala Glu Glu Ala
1825                1830                1835                1840
Lys Arg Gln Arg Gln Leu Ala Glu Glu Asp Ala Ala Arg Gln Arg Ala
                1845                1850                1855    
Glu Ala Glu Arg Val Leu Ala Glu Lys Leu Ala Ala Ile Gly Glu Ala
            1860                1865                1870        
Thr Arg Leu Lys Thr Glu Ala Glu Ile Ala Leu Lys Glu Lys Glu Ala
        1875                1880                1885            
Glu Asn Glu Arg Leu Arg Arg Leu Ala Glu Asp Glu Ala Phe Gln Arg
    1890                1895                1900                
Arg Arg Leu Glu Glu Gln Ala Ala Gln His Lys Ala Asp Ile Glu Glu
1905                1910                1915                1920
Arg Leu Ala Gln Leu Arg Lys Ala Ser Asp Ser Glu Leu Glu Arg Gln
                1925                1930                1935    
Lys Gly Leu Val Glu Asp Thr Leu Arg Gln Arg Arg Gln Val Glu Glu
            1940                1945                1950        
Glu Ile Leu Ala Leu Lys Ala Ser Phe Glu Lys Ala Ala Ala Gly Lys
        1955                1960                1965            
Ala Glu Leu Glu Leu Glu Leu Gly Arg Ile Arg Ser Asn Ala Glu Asp
    1970                1975                1980                
Thr Leu Arg Ser Lys Glu Gln Ala Glu Leu Glu Ala Ala Arg Gln Arg
1985                1990                1995                2000
Gln Leu Ala Ala Glu Glu Glu Arg Arg Arg Arg Glu Ala Glu Glu Arg
                2005                2010                2015    
Val Gln Lys Ser Leu Ala Ala Glu Glu Glu Ala Ala Arg Gln Arg Lys
            2020                2025                2030        
Ala Ala Leu Glu Glu Val Glu Arg Leu Lys Ala Lys Val Glu Glu Ala
        2035                2040                2045            
Arg Ser Leu Arg Glu Arg Ala Glu Gln Glu Ser Ala Arg Gln Leu Gln
    2050                2055                2060                
Leu Ala Gln Glu Ala Ala Gln Lys Arg Leu Gln Ala Glu Glu Lys Ala
2065                2070                2075                2080
His Ala Phe Ala Val Gln Gln Lys Glu Gln Glu Leu Gln Gln Thr Leu
                2085                2090                2095    
Gln Gln Glu Gln Ser Val Leu Asp Arg Leu Arg Gly Glu Ala Glu Ala
            2100                2105                2110        
Ala Arg Arg Ala Ala Glu Glu Ala Glu Glu Ala Arg Val Gln Ala Glu
        2115                2120                2125            
Arg Glu Ala Ala Gln Ser Arg Arg Gln Val Glu Glu Ala Glu Arg Leu
    2130                2135                2140                
Lys Gln Ser Ala Glu Glu Gln Ala Gln Ala Arg Ala Gln Ala Gln Ala
2145                2150                2155                2160
Ala Ala Glu Lys Leu Arg Lys Glu Ala Glu Gln Glu Ala Ala Arg Arg
                2165                2170                2175    
Ala Gln Ala Glu Gln Ala Ala Leu Arg Gln Lys Gln Ala Ala Asp Ala
            2180                2185                2190        
Glu Met Glu Lys His Lys Lys Phe Ala Glu Gln Thr Leu Arg Gln Lys
        2195                2200                2205            
Ala Gln Val Glu Gln Glu Leu Thr Thr Leu Arg Leu Gln Leu Glu Glu
    2210                2215                2220                
Thr Asp His Gln Lys Asn Leu Leu Asp Glu Glu Leu Gln Arg Leu Lys
2225                2230                2235                2240
Ala Glu Ala Thr Glu Ala Ala Arg Gln Arg Ser Gln Val Glu Glu Glu
                2245                2250                2255    
Leu Phe Ser Val Arg Val Gln Met Glu Glu Leu Ser Lys Leu Lys Ala
            2260                2265                2270        
Arg Ile Glu Ala Glu Asn Arg Ala Leu Ile Leu Arg Asp Lys Asp Asn
        2275                2280                2285            
Thr Gln Arg Phe Leu Gln Glu Glu Ala Glu Lys Met Lys Gln Val Ala
    2290                2295                2300                
Glu Glu Ala Ala Arg Leu Ser Val Ala Ala Gln Glu Ala Ala Arg Leu
2305                2310                2315                2320
Arg Gln Leu Ala Glu Glu Asp Leu Ala Gln Gln Arg Ala Leu Ala Glu
                2325                2330                2335    
Lys Met Leu Lys Glu Lys Met Gln Ala Val Gln Glu Ala Thr Arg Leu
            2340                2345                2350        
Lys Ala Glu Ala Glu Leu Leu Gln Gln Gln Lys Glu Leu Ala Gln Glu
        2355                2360                2365            
Gln Ala Arg Arg Leu Gln Glu Asp Lys Glu Gln Met Ala Gln Gln Leu
    2370                2375                2380                
Ala Glu Glu Thr Gln Gly Phe Gln Arg Thr Leu Glu Ala Glu Arg Gln
2385                2390                2395                2400
Arg Gln Leu Glu Met Ser Ala Glu Ala Glu Arg Leu Lys Leu Arg Val
                2405                2410                2415    
Ala Glu Met Ser Arg Ala Gln Ala Arg Ala Glu Glu Asp Ala Gln Arg
            2420                2425                2430        
Phe Arg Lys Gln Ala Glu Glu Ile Gly Glu Lys Leu His Arg Thr Glu
        2435                2440                2445            
Leu Ala Thr Gln Glu Lys Val Thr Leu Val Gln Thr Leu Glu Ile Gln
    2450                2455                2460                
Arg Gln Gln Ser Asp His Asp Ala Glu Arg Leu Arg Glu Ala Ile Ala
2465                2470                2475                2480
Glu Leu Glu Arg Glu Lys Glu Lys Leu Gln Gln Glu Ala Lys Leu Leu
                2485                2490                2495    
Gln Leu Lys Ser Glu Glu Met Gln Thr Val Gln Gln Glu Gln Leu Leu
            2500                2505                2510        
Gln Glu Thr Gln Ala Leu Gln Gln Ser Phe Leu Ser Glu Lys Asp Ser
        2515                2520                2525            
Leu Leu Gln Arg Glu Arg Phe Ile Glu Gln Glu Lys Ala Lys Leu Glu
    2530                2535                2540                
Gln Leu Phe Gln Asp Glu Val Ala Lys Ala Gln Gln Leu Arg Glu Glu
2545                2550                2555                2560
Gln Gln Arg Gln Gln Gln Gln Met Glu Gln Glu Arg Gln Arg Leu Val
                2565                2570                2575    
Ala Ser Met Glu Glu Ala Arg Arg Arg Gln His Glu Ala Glu Glu Gly
            2580                2585                2590        
Val Arg Arg Lys Gln Glu Glu Leu Gln Gln Leu Glu Gln Gln Arg Arg
        2595                2600                2605            
Gln Gln Glu Glu Leu Leu Ala Glu Glu Asn Gln Arg Leu Arg Glu Gln
    2610                2615                2620                
Leu Gln Leu Leu Glu Glu Gln His Arg Ala Ala Leu Ala His Ser Glu
2625                2630                2635                2640
Glu Val Thr Ala Ser Gln Val Ala Ala Thr Lys Thr Leu Pro Asn Gly
                2645                2650                2655    
Arg Asp Ala Leu Asp Gly Pro Ala Ala Glu Ala Glu Pro Glu His Ser
            2660                2665                2670        
Phe Asp Gly Leu Arg Arg Lys Val Ser Ala Gln Arg Leu Gln Glu Ala
        2675                2680                2685            
Gly Ile Leu Ser Ala Glu Glu Leu Gln Arg Leu Ala Gln Gly His Thr
    2690                2695                2700                
Thr Val Asp Glu Leu Ala Arg Arg Glu Asp Val Arg His Tyr Leu Gln
2705                2710                2715                2720
Gly Arg Ser Ser Ile Ala Gly Leu Leu Leu Lys Ala Thr Asn Glu Lys
                2725                2730                2735    
Leu Ser Val Tyr Ala Ala Leu Gln Arg Gln Leu Leu Ser Pro Gly Thr
            2740                2745                2750        
Ala Leu Ile Leu Leu Glu Ala Gln Ala Ala Ser Gly Phe Leu Leu Asp
        2755                2760                2765            
Pro Val Arg Asn Arg Arg Leu Thr Val Asn Glu Ala Val Lys Glu Gly
    2770                2775                2780                
Val Val Gly Pro Glu Leu His His Lys Leu Leu Ser Ala Glu Arg Ala
2785                2790                2795                2800
Val Thr Gly Tyr Lys Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe
                2805                2810                2815    
Gln Ala Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu
            2820                2825                2830        
Leu Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser
        2835                2840                2845            
His Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp Glu
    2850                2855                2860                
Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly Phe
2865                2870                2875                2880
Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln Leu Leu Glu
                2885                2890                2895    
Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Cys Leu Leu Pro Leu Thr
            2900                2905                2910        
Asp Lys Ala Ala Lys Gly Gly Glu Leu Val Tyr Thr Asp Ser Glu Ala
        2915                2920                2925            
Arg Asp Val Phe Glu Lys Ala Thr Val Ser Ala Pro Phe Gly Lys Phe
    2930                2935                2940                
Gln Gly Lys Thr Val Thr Ile Trp Glu Ile Ile Asn Ser Glu Tyr Phe
2945                2950                2955                2960
Thr Ala Glu Gln Arg Arg Asp Leu Leu Arg Gln Phe Arg Thr Gly Arg
                2965                2970                2975    
Ile Thr Val Glu Lys Ile Ile Lys Ile Ile Ile Thr Val Val Glu Glu
            2980                2985                2990        
Gln Glu Gln Lys Gly Arg Leu Cys Phe Glu Gly Leu Arg Ser Leu Val
        2995                3000                3005            
Pro Ala Ala Glu Leu Leu Glu Ser Arg Val Ile Asp Arg Glu Leu Tyr
    3010                3015                3020                
Gln Gln Leu Gln Arg Gly Glu Arg Ser Val Arg Asp Val Ala Glu Val
3025                3030                3035                3040
Asp Thr Val Arg Arg Ala Leu Arg Gly Ala Asn Val Ile Ala Gly Val
                3045                3050                3055    
Trp Leu Glu Glu Ala Gly Gln Lys Leu Ser Ile Tyr Asn Ala Leu Lys
            3060                3065                3070        
Lys Asp Leu Leu Pro Ser Asp Met Ala Val Ala Leu Leu Glu Ala Gln
        3075                3080                3085            
Ala Gly Thr Gly His Ile Ile Asp Pro Ala Thr Ser Ala Arg Leu Thr
    3090                3095                3100                
Val Asp Glu Ala Val Arg Ala Gly Leu Val Gly Pro Glu Phe His Glu
3105                3110                3115                3120
Lys Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr Arg Asp Pro Tyr
                3125                3130                3135    
Thr Gly Gln Ser Val Ser Leu Phe Gln Ala Leu Lys Lys Gly Leu Ile
            3140                3145                3150        
Pro Arg Glu Gln Gly Leu Arg Leu Leu Asp Ala Gln Leu Ser Thr Gly
        3155                3160                3165            
Gly Ile Val Asp Pro Ser Lys Ser His Arg Val Pro Leu Asp Val Ala
    3170                3175                3180                
Cys Ala Arg Gly Cys Leu Asp Glu Glu Thr Ser Arg Ala Leu Ser Glu
3185                3190                3195                3200
Pro Arg Ala Asp Ala Lys Ala Tyr Ser Asp Pro Ser Thr Gly Glu Pro
                3205                3210                3215    
Ala Thr Tyr Gly Glu Leu Gln Gln Arg Cys Arg Pro Asp Gln Leu Thr
            3220                3225                3230        
Gly Leu Ser Leu Leu Pro Leu Ser Glu Lys Ala Ala Arg Ala Arg Gln
        3235                3240                3245            
Glu Glu Phe Tyr Ser Glu Leu Gln Ala Arg Glu Thr Phe Glu Lys Thr
    3250                3255                3260                
Pro Val Glu Val Pro Val Gly Gly Phe Lys Gly Arg Thr Val Thr Val
3265                3270                3275                3280
Trp Glu Leu Ile Ser Ser Glu Tyr Phe Thr Ala Glu Gln Arg Gln Glu
                3285                3290                3295    
Leu Phe Arg Gln Phe Arg Thr Gly Lys Val Thr Val Glu Lys Val Ile
            3300                3305                3310        
Lys Ile Leu Ile Thr Ile Val Glu Glu Val Glu Thr Leu Arg Gln Glu
        3315                3320                3325            
Arg Leu Ser Phe Ser Gly Leu Arg Ser Pro Val Pro Ala Ser Glu Leu
    3330                3335                3340                
Leu Ala Ser Gly Val Leu Ser Arg Ala Gln Phe Glu Gln Leu Lys Asp
3345                3350                3355                3360
Gly Lys Thr Thr Val Lys Asp Leu Ser Glu Leu Gly Ser Val Arg Thr
                3365                3370                3375    
Leu Leu Gln Gly Ser Gly Cys Leu Ala Gly Ile Tyr Leu Glu Asp Thr
            3380                3385                3390        
Lys Glu Lys Val Ser Ile Tyr Glu Ala Met Arg Arg Gly Leu Leu Arg
        3395                3400                3405            
Ala Thr Thr Ala Ala Leu Leu Leu Glu Ala Gln Ala Gly Thr Gly Phe
    3410                3415                3420                
Leu Val Asp Pro Val Arg Asn Gln Arg Leu Tyr Val His Glu Ala Val
3425                3430                3435                3440
Lys Ala Gly Val Val Gly Pro Glu Leu His Glu Gln Leu Leu Ser Ala
                3445                3450                3455    
Glu Lys Ala Val Thr Gly Tyr Arg Asp Pro Tyr Ser Gly Arg Thr Ile
            3460                3465                3470        
Ser Leu Phe Gln Ala Met Lys Lys Gly Leu Val Leu Arg Glu His Gly
        3475                3480                3485            
Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro
    3490                3495                3500                
Val Asn Ser His Arg Val Pro Val Asp Val Ala Tyr Gln Arg Gly Tyr
3505                3510                3515                3520
Phe Ser Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr
                3525                3530                3535    
Lys Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Arg Gln
            3540                3545                3550        
Leu Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Arg Leu Leu
        3555                3560                3565            
Pro Leu Lys Gly Ala Glu Lys Val Glu Val Val Glu Thr Thr Gln Val
    3570                3575                3580                
Tyr Thr Glu Glu Glu Thr Arg Arg Ala Phe Glu Glu Thr Gln Ile Asp
3585                3590                3595                3600
Ile Pro Gly Gly Gly Ser His Gly Gly Ser Thr Met Ser Leu Trp Glu
                3605                3610                3615    
Val Met Gln Ser Asp Leu Ile Pro Glu Glu Gln Arg Ala Gln Leu Met
            3620                3625                3630        
Ala Asp Phe Gln Ala Gly Arg Val Thr Lys Glu Arg Met Ile Ile Ile
        3635                3640                3645            
Ile Ile Glu Ile Ile Glu Lys Thr Glu Ile Ile Arg Gln Gln Gly Leu
    3650                3655                3660                
Ala Ser Tyr Asp Tyr Val Arg Arg Arg Leu Thr Gly Glu Asp Leu Phe
3665                3670                3675                3680
Glu Ala Arg Ile Ile Ser Leu Glu Thr Tyr Asn Leu Leu Arg Glu Gly
                3685                3690                3695    
Thr Lys Ser Leu Arg Glu Ala Leu Glu Gly Glu Ser Ala Trp Phe Tyr
            3700                3705                3710        
Leu Tyr Gly Thr Gly Ser Val Ala Gly Val Tyr Leu Pro Gly Ser Arg
        3715                3720                3725            
Gln Thr Leu Ser Ile Tyr Gln Ala Leu Lys Lys Gly Leu Leu Ser Ala
    3730                3735                3740                
Glu Val Ala Arg Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Leu
3745                3750                3755                3760
Leu Asp Pro Val Lys Gly Glu Arg Leu Thr Val Asp Glu Ala Val Arg
                3765                3770                3775    
Lys Gly Leu Val Gly Pro Glu Leu His Asp Arg Leu Leu Ser Ala Glu
            3780                3785                3790        
Arg Ala Val Thr Gly Tyr Arg Asp Pro Tyr Thr Glu Lys Thr Ile Ser
        3795                3800                3805            
Leu Phe Gln Ala Met Lys Lys Glu Leu Ile Pro Thr Glu Glu Ala Leu
    3810                3815                3820                
Arg Leu Leu Asp Ala Gln Leu Ala Thr Gly Gly Ile Val Asp Pro Arg
3825                3830                3835                3840
Leu Gly Phe His Leu Pro Leu Glu Val Ala Tyr Gln Arg Gly Tyr Leu
                3845                3850                3855    
Asn Lys Asp Thr His Asp Gln Leu Ser Glu Pro Ser Glu Val Arg Ser
            3860                3865                3870        
Tyr Val Asp Pro Ser Thr Asp Glu Arg Leu Ser Tyr Thr Gln Leu Leu
        3875                3880                3885            
Lys Arg Cys Arg Arg Asp Asp Gly Ser Gly Gln Leu Leu Leu Pro Leu
    3890                3895                3900                
Ser Asp Ala Arg Lys Leu Thr Phe Arg Gly Leu Arg Lys Gln Ile Thr
3905                3910                3915                3920
Met Glu Glu Leu Val Arg Ser Gln Val Met Asp Glu Ala Thr Ala Leu
                3925                3930                3935    
Gln Leu Arg Glu Gly Leu Thr Ser Ile Glu Glu Val Thr Lys Asn Leu
            3940                3945                3950        
Gln Lys Phe Leu Glu Gly Thr Ser Cys Ile Ala Gly Val Phe Val Asp
        3955                3960                3965            
Ala Thr Lys Glu Arg Leu Ser Val Tyr Gln Ala Met Lys Lys Gly Ile
    3970                3975                3980                
Ile Arg Pro Gly Thr Ala Phe Glu Leu Leu Glu Ala Gln Ala Ala Thr
3985                3990                3995                4000
Gly Tyr Val Ile Asp Pro Ile Lys Gly Leu Lys Leu Thr Val Glu Glu
                4005                4010                4015    
Ala Val Arg Met Gly Ile Val Gly Pro Glu Phe Lys Asp Lys Leu Leu
            4020                4025                4030        
Ser Ala Glu Arg Ala Val Thr Gly Tyr Lys Asp Pro Tyr Ser Gly Lys
        4035                4040                4045            
Leu Ile Ser Leu Phe Gln Ala Met Lys Lys Gly Leu Ile Leu Lys Asp
    4050                4055                4060                
His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Ile Ile
4065                4070                4075                4080
Asp Pro Glu Glu Ser His Arg Leu Pro Val Glu Val Ala Tyr Lys Arg
                4085                4090                4095    
Gly Leu Phe Asp Glu Glu Met Asn Glu Ile Leu Thr Asp Pro Ser Asp
            4100                4105                4110        
Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr Glu Glu Asn Leu Thr Tyr
        4115                4120                4125            
Leu Gln Leu Met Glu Arg Cys Ile Thr Asp Pro Gln Thr Gly Leu Cys
    4130                4135                4140                
Leu Leu Pro Leu Lys Glu Lys Lys Arg Glu Arg Lys Thr Ser Ser Lys
4145                4150                4155                4160
Ser Ser Val Arg Lys Arg Arg Val Val Ile Val Asp Pro Glu Thr Gly
                4165                4170                4175    
Lys Glu Met Ser Val Tyr Glu Ala Tyr Arg Lys Gly Leu Ile Asp His
            4180                4185                4190        
Gln Thr Tyr Leu Glu Leu Ser Glu Gln Glu Cys Glu Trp Glu Glu Ile
        4195                4200                4205            
Thr Ile Ser Ser Ser Asp Gly Val Val Lys Ser Met Ile Ile Asp Arg
    4210                4215                4220                
Arg Ser Gly Arg Gln Tyr Asp Ile Asp Asp Ala Ile Ala Lys Asn Leu
4225                4230                4235                4240
Ile Asp Arg Ser Ala Leu Asp Gln Tyr Arg Ala Gly Thr Leu Ser Ile
                4245                4250                4255    
Thr Glu Phe Ala Asp Met Leu Ser Gly Asn Ala Gly Gly Phe Arg Ser
            4260                4265                4270        
Arg Ser Ser Ser Val Gly Ser Ser Ser Ser Tyr Pro Ile Ser Pro Ala
        4275                4280                4285            
Val Ser Arg Thr Gln Leu Ala Ser Trp Ser Asp Pro Thr Glu Glu Thr
    4290                4295                4300                
Gly Pro Val Ala Gly Ile Leu Asp Thr Glu Thr Leu Glu Lys Val Ser
4305                4310                4315                4320
Ile Thr Glu Ala Met His Arg Asn Leu Val Asp Asn Ile Thr Gly Gln
                4325                4330                4335    
Arg Leu Leu Glu Ala Gln Ala Cys Thr Gly Gly Ile Ile Asp Pro Ser
            4340                4345                4350        
Thr Gly Glu Arg Leu Pro Val Thr Asp Ala Val Asn Lys Gly Leu Val
        4355                4360                4365            
Asp Lys Ile Met Val Asp Arg Ile Asn Leu Ala Gln Lys Ala Phe Cys
    4370                4375                4380                
Gly Phe Glu Asp Pro Arg Thr Lys Thr Lys Met Ser Ala Ala Gln Ala
4385                4390                4395                4400
Leu Lys Lys Gly Trp Leu Tyr Tyr Glu Ala Gly Gln Arg Phe Leu Glu
                4405                4410                4415    
Val Gln Tyr Leu Thr Gly Gly Leu Ile Glu Pro Asp Thr Pro Gly Arg
            4420                4425                4430        
Val Pro Leu Asp Glu Ala Leu Gln Arg Gly Thr Val Asp Ala Arg Thr
        4435                4440                4445            
Ala Gln Lys Leu Arg Asp Val Gly Ala Tyr Ser Lys Tyr Leu Thr Cys
    4450                4455                4460                
Pro Lys Thr Lys Leu Lys Ile Ser Tyr Lys Asp Ala Leu Asp Arg Ser
4465                4470                4475                4480
Met Val Glu Glu Gly Thr Gly Leu Arg Leu Leu Glu Ala Ala Ala Gln
                4485                4490                4495    
Ser Thr Lys Gly Tyr Tyr Ser Pro Tyr Ser Val Ser Gly Ser Gly Ser
            4500                4505                4510        
Thr Ala Gly Ser Arg Thr Gly Ser Arg Thr Gly Ser Arg Ala Gly Ser
        4515                4520                4525            
Arg Arg Gly Ser Phe Asp Ala Thr Gly Ser Gly Phe Ser Met Thr Phe
    4530                4535                4540                
Ser Ser Ser Ser Tyr Ser Ser Ser Gly Tyr Gly Arg Arg Tyr Ala Ser
4545                4550                4555                4560
Gly Ser Ser Ala Ser Leu Gly Gly Pro Glu Ser Ala Val Ala
                4565                4570                


<210> 7788
<211> 4684
<212> PRT
<213> Homo sapiens

<400> 7788
Met Val Ala Gly Met Leu Met Pro Arg Asp Gln Leu Arg Ala Ile Tyr
 1               5                  10                  15      
Glu Val Leu Phe Arg Glu Gly Val Met Val Ala Lys Lys Asp Arg Arg
            20                  25                  30          
Pro Arg Ser Leu His Pro His Val Pro Gly Val Thr Asn Leu Gln Val
        35                  40                  45              
Met Arg Ala Met Ala Ser Leu Arg Ala Arg Gly Leu Val Arg Glu Thr
    50                  55                  60                  
Phe Ala Trp Cys His Phe Phe Trp Tyr Leu Thr Asn Glu Gly Ile Ala
65                  70                  75                  80  
His Leu Arg Gln Tyr Leu His Leu Pro Pro Glu Ile Val Ala Ala Ser
                85                  90                  95      
Leu Gln Arg Val Arg Arg Pro Val Ala Met Val Met Pro Ala Arg Arg
            100                 105                 110         
Thr Pro His Val Gln Ala Val Gln Gly Pro Leu Gly Ser Pro Pro Lys
        115                 120                 125             
Arg Gly Pro Leu Pro Thr Glu Glu Gln Arg Leu Tyr Arg Arg Lys Glu
    130                 135                 140                 
Leu Glu Glu Val Ser Pro Glu Thr Pro Val Val Pro Ala Thr Thr Gln
145                 150                 155                 160 
Arg Thr Leu Ala Arg Pro Gly Pro Glu Pro Ala Pro Ala Thr Asp Glu
                165                 170                 175     
Arg Asp Arg Val Gln Lys Lys Thr Ser Thr Lys Trp Val Asn Lys His
            180                 185                 190         
Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp Leu Arg
        195                 200                 205             
Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Ser
    210                 215                 220                 
Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln Asn Val
225                 230                 235                 240 
Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu Val Asn
                245                 250                 255     
Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr Leu Gly
            260                 265                 270         
Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile Gln Val
        275                 280                 285             
Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu Leu Trp
    290                 295                 300                 
Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp Asn Phe
305                 310                 315                 320 
Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile His Arg
                325                 330                 335     
His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln Thr Asn
            340                 345                 350         
Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp Leu Gly
        355                 360                 365             
Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln Pro Asp
    370                 375                 380                 
Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Met Pro
385                 390                 395                 400 
Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu Gln Leu
                405                 410                 415     
Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp Met
            420                 425                 430         
Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser Phe
        435                 440                 445             
Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu Met
    450                 455                 460                 
Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile Tyr
465                 470                 475                 480 
Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro Pro
                485                 490                 495     
Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His Val
            500                 505                 510         
Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg Leu
        515                 520                 525             
Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly Leu
    530                 535                 540                 
Cys Glu Glu Gln Leu His Gln Ala Asp Ala Leu Leu Gln Ser Asp Ile
545                 550                 555                 560 
Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val Glu
                565                 570                 575     
Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn Asp
            580                 585                 590         
Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met Tyr
        595                 600                 605             
Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr Glu
    610                 615                 620                 
Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln Val
625                 630                 635                 640 
Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu Asp
                645                 650                 655     
Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu Asn
            660                 665                 670         
Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser Val
        675                 680                 685             
Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu Glu
    690                 695                 700                 
Phe Gln Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu Ser
705                 710                 715                 720 
Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp Leu
                725                 730                 735     
Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser Leu
            740                 745                 750         
Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met Trp
        755                 760                 765             
Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp Arg
    770                 775                 780                 
Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met Arg
785                 790                 795                 800 
Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala Gly
                805                 810                 815     
Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu Ser
            820                 825                 830         
Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys
        835                 840                 845             
Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe
    850                 855                 860                 
Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu
865                 870                 875                 880 
Ala Leu Arg Arg Lys Asn Ser Cys Asp Arg Ser Ala Thr Val Thr Arg
                885                 890                 895     
Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn
            900                 905                 910         
Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val
        915                 920                 925             
Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu
    930                 935                 940                 
Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His
945                 950                 955                 960 
Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp
                965                 970                 975     
Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys
            980                 985                 990         
Phe Leu Val Pro Pro Pro Asn Gln Glu Val Gln Glu Ala Val Thr Arg
        995                 1000                1005            
Leu Glu Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln Leu His
    1010                1015                1020                
Val Asp Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg Asp Val
1025                1030                1035                1040
Gln Leu Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr Leu Lys Pro
                1045                1050                1055    
Glu Glu Gln Arg Gln Ala Leu His Ser Leu Glu Leu His Tyr Gln Ala
            1060                1065                1070        
Phe Leu Arg Asp Ser Gln Asp Ala Gly Gly Phe Gly Pro Glu Asp Arg
        1075                1080                1085            
Leu Met Ala Glu Arg Glu Tyr Gly Ser Cys Ser His His Tyr Gln Gln
    1090                1095                1100                
Leu Leu Gln Ser Leu Glu Gln Gly Ala Gln Glu Glu Ser Arg Cys Gln
1105                1110                1115                1120
Arg Cys Ile Ser Glu Leu Lys Asp Ile Arg Leu Gln Leu Glu Ala Cys
                1125                1130                1135    
Glu Thr Arg Thr Val His Arg Leu Arg Leu Pro Leu Asp Lys Glu Pro
            1140                1145                1150        
Ala Arg Glu Cys Ala Gln Arg Ile Ala Glu Gln Gln Lys Ala Gln Ala
        1155                1160                1165            
Glu Val Glu Gly Leu Gly Lys Gly Val Ala Arg Leu Ser Ala Glu Ala
    1170                1175                1180                
Glu Lys Val Leu Ala Leu Pro Glu Pro Ser Pro Ala Ala Pro Thr Leu
1185                1190                1195                1200
Arg Ser Glu Leu Glu Leu Thr Leu Gly Lys Leu Glu Gln Val Arg Ser
                1205                1210                1215    
Leu Ser Ala Ile Tyr Leu Glu Lys Leu Lys Thr Ile Ser Leu Val Ile
            1220                1225                1230        
Arg Gly Thr Gln Gly Ala Glu Glu Val Leu Arg Ala His Glu Glu Gln
        1235                1240                1245            
Leu Lys Glu Ala Gln Ala Val Pro Ala Thr Leu Pro Glu Leu Glu Ala
    1250                1255                1260                
Thr Lys Ala Ser Leu Lys Lys Leu Arg Ala Gln Ala Glu Ala Gln Gln
1265                1270                1275                1280
Pro Thr Phe Asp Ala Leu Arg Asp Glu Leu Arg Gly Ala Gln Glu Val
                1285                1290                1295    
Gly Glu Arg Leu Gln Gln Arg His Gly Glu Arg Asp Val Glu Val Glu
            1300                1305                1310        
Arg Trp Arg Glu Arg Val Ala Gln Leu Leu Glu Arg Trp Gln Ala Val
        1315                1320                1325            
Leu Ala Gln Thr Asp Val Arg Gln Arg Glu Leu Glu Gln Leu Gly Arg
    1330                1335                1340                
Gln Leu Arg Tyr Tyr Arg Glu Ser Ala Asp Pro Leu Gly Ala Trp Leu
1345                1350                1355                1360
Gln Asp Ala Arg Arg Arg Gln Glu Gln Ile Gln Ala Met Pro Leu Ala
                1365                1370                1375    
Asp Ser Gln Ala Val Arg Glu Gln Leu Arg Gln Glu Gln Ala Leu Leu
            1380                1385                1390        
Glu Glu Ile Glu Arg His Gly Glu Lys Val Glu Glu Cys Gln Arg Phe
        1395                1400                1405            
Ala Lys Gln Tyr Ile Asn Ala Ile Lys Asp Tyr Glu Leu Gln Leu Val
    1410                1415                1420                
Thr Tyr Lys Ala Gln Leu Glu Pro Val Ala Ser Pro Ala Lys Lys Pro
1425                1430                1435                1440
Lys Val Gln Ser Gly Ser Glu Ser Val Ile Gln Glu Tyr Val Asp Leu
                1445                1450                1455    
Arg Thr His Tyr Ser Glu Leu Thr Thr Leu Thr Ser Gln Tyr Ile Lys
            1460                1465                1470        
Phe Ile Ser Glu Thr Leu Arg Arg Met Glu Glu Glu Glu Arg Leu Ala
        1475                1480                1485            
Glu Gln Gln Arg Ala Glu Glu Arg Glu Arg Leu Ala Glu Val Glu Ala
    1490                1495                1500                
Ala Leu Glu Lys Gln Arg Gln Leu Ala Glu Ala His Ala Gln Ala Lys
1505                1510                1515                1520
Ala Gln Ala Glu Arg Glu Ala Lys Glu Leu Gln Gln Arg Ile Gln Glu
                1525                1530                1535    
Glu Val Val Arg Arg Glu Glu Ala Ala Val Asp Ala Gln Gln Gln Lys
            1540                1545                1550        
Arg Ser Ile Gln Glu Glu Leu Gln Gln Leu Arg Gln Ser Ser Glu Ala
        1555                1560                1565            
Glu Ile Gln Ala Lys Ala Arg Gln Ala Glu Ala Ala Glu Arg Ser Arg
    1570                1575                1580                
Leu Arg Ile Glu Glu Glu Ile Arg Val Val Arg Leu Gln Leu Glu Ala
1585                1590                1595                1600
Thr Glu Arg Gln Arg Gly Gly Ala Glu Gly Glu Leu Gln Ala Leu Arg
                1605                1610                1615    
Ala Arg Ala Glu Glu Ala Glu Ala Gln Lys Arg Gln Ala Gln Glu Glu
            1620                1625                1630        
Ala Glu Arg Leu Arg Arg Gln Val Gln Asp Glu Ser Gln Arg Lys Arg
        1635                1640                1645            
Gln Ala Glu Val Glu Leu Ala Ser Arg Val Lys Ala Glu Ala Glu Ala
    1650                1655                1660                
Ala Arg Glu Lys Gln Arg Ala Leu Gln Ala Leu Glu Glu Leu Arg Leu
1665                1670                1675                1680
Gln Ala Glu Glu Ala Glu Arg Trp Leu Cys Gln Ala Glu Val Glu Arg
                1685                1690                1695    
Ala Arg Gln Val Gln Val Ala Leu Glu Thr Ala Gln Arg Ser Ala Glu
            1700                1705                1710        
Ala Glu Leu Gln Ser Lys Arg Ala Ser Phe Ala Glu Lys Thr Ala Gln
        1715                1720                1725            
Leu Glu Arg Ser Leu Gln Glu Glu His Val Ala Val Ala Gln Leu Arg
    1730                1735                1740                
Glu Glu Ala Glu Arg Arg Ala Gln Gln Gln Ala Glu Ala Glu Arg Ala
1745                1750                1755                1760
Arg Glu Glu Ala Glu Arg Gln Leu Glu Arg Trp Gln Leu Lys Ala Asn
                1765                1770                1775    
Glu Ala Leu Arg Leu Arg Leu Gln Ala Glu Glu Val Leu Gln Gln Lys
            1780                1785                1790        
Ser Leu Ala Gln Ala Glu Ala Glu Lys Gln Lys Glu Glu Ala Glu Arg
        1795                1800                1805            
Glu Ala Arg Arg Arg Gly Lys Ala Glu Glu Gln Ala Val Arg Gln Arg
    1810                1815                1820                
Glu Leu Ala Glu Gln Glu Leu Glu Lys Gln Arg Gln Leu Ala Glu Gly
1825                1830                1835                1840
Thr Ala Gln Gln Arg Leu Ala Ala Glu Gln Glu Leu Ile Arg Leu Arg
                1845                1850                1855    
Ala Glu Thr Glu Gln Gly Glu Gln Gln Arg Gln Leu Leu Glu Glu Glu
            1860                1865                1870        
Leu Ala Arg Leu Gln Arg Glu Ala Ala Ala Ala Thr Gln Lys Arg Gln
        1875                1880                1885            
Glu Leu Glu Ala Glu Leu Ala Lys Val Arg Ala Glu Met Glu Val Leu
    1890                1895                1900                
Leu Ala Ser Lys Ala Lys Ala Glu Glu Glu Ser Arg Ser Thr Ser Glu
1905                1910                1915                1920
Lys Ser Lys Gln Arg Leu Glu Ala Glu Ala Gly Arg Phe Arg Glu Leu
                1925                1930                1935    
Ala Glu Glu Ala Ala Arg Leu Arg Ala Leu Ala Glu Glu Ala Lys Arg
            1940                1945                1950        
Gln Arg Gln Leu Ala Glu Glu Asp Ala Ala Arg Gln Arg Ala Glu Ala
        1955                1960                1965            
Glu Arg Val Leu Ala Glu Lys Leu Ala Ala Ile Gly Glu Ala Thr Arg
    1970                1975                1980                
Leu Lys Thr Glu Ala Glu Ile Ala Leu Lys Glu Lys Glu Ala Glu Asn
1985                1990                1995                2000
Glu Arg Leu Arg Arg Leu Ala Glu Asp Glu Ala Phe Gln Arg Arg Arg
                2005                2010                2015    
Leu Glu Glu Gln Ala Ala Gln His Lys Ala Asp Ile Glu Glu Arg Leu
            2020                2025                2030        
Ala Gln Leu Arg Lys Ala Ser Asp Ser Glu Leu Glu Arg Gln Lys Gly
        2035                2040                2045            
Leu Val Glu Asp Thr Leu Arg Gln Arg Arg Gln Val Glu Glu Glu Ile
    2050                2055                2060                
Leu Ala Leu Lys Ala Ser Phe Glu Lys Ala Ala Ala Gly Lys Ala Glu
2065                2070                2075                2080
Leu Glu Leu Glu Leu Gly Arg Ile Arg Ser Asn Ala Glu Asp Thr Leu
                2085                2090                2095    
Arg Ser Lys Glu Gln Ala Glu Leu Glu Ala Ala Arg Gln Arg Gln Leu
            2100                2105                2110        
Ala Ala Glu Glu Glu Arg Arg Arg Arg Glu Ala Glu Glu Arg Val Gln
        2115                2120                2125            
Lys Ser Leu Ala Ala Glu Glu Glu Ala Ala Arg Gln Arg Lys Ala Ala
    2130                2135                2140                
Leu Glu Glu Val Glu Arg Leu Lys Ala Lys Val Glu Glu Ala Arg Ser
2145                2150                2155                2160
Leu Arg Glu Arg Ala Glu Gln Glu Ser Ala Arg Gln Leu Gln Leu Ala
                2165                2170                2175    
Gln Glu Ala Ala Gln Lys Arg Leu Gln Ala Glu Glu Lys Ala His Ala
            2180                2185                2190        
Phe Ala Val Gln Gln Lys Glu Gln Glu Leu Gln Gln Thr Leu Gln Gln
        2195                2200                2205            
Glu Gln Ser Val Leu Asp Arg Leu Arg Gly Glu Ala Glu Ala Ala Arg
    2210                2215                2220                
Arg Ala Ala Glu Glu Ala Glu Glu Ala Arg Val Gln Ala Glu Arg Glu
2225                2230                2235                2240
Ala Ala Gln Ser Arg Arg Gln Val Glu Glu Ala Glu Arg Leu Lys Gln
                2245                2250                2255    
Ser Ala Glu Glu Gln Ala Gln Ala Arg Ala Gln Ala Gln Ala Ala Ala
            2260                2265                2270        
Glu Lys Leu Arg Lys Glu Ala Glu Gln Glu Ala Ala Arg Arg Ala Gln
        2275                2280                2285            
Ala Glu Gln Ala Ala Leu Arg Gln Lys Gln Ala Ala Asp Ala Glu Met
    2290                2295                2300                
Glu Lys His Lys Lys Phe Ala Glu Gln Thr Leu Arg Gln Lys Ala Gln
2305                2310                2315                2320
Val Glu Gln Glu Leu Thr Thr Leu Arg Leu Gln Leu Glu Glu Thr Asp
                2325                2330                2335    
His Gln Lys Asn Leu Leu Asp Glu Glu Leu Gln Arg Leu Lys Ala Glu
            2340                2345                2350        
Ala Thr Glu Ala Ala Arg Gln Arg Ser Gln Val Glu Glu Glu Leu Phe
        2355                2360                2365            
Ser Val Arg Val Gln Met Glu Glu Leu Ser Lys Leu Lys Ala Arg Ile
    2370                2375                2380                
Glu Ala Glu Asn Arg Ala Leu Ile Leu Arg Asp Lys Asp Asn Thr Gln
2385                2390                2395                2400
Arg Phe Leu Gln Glu Glu Ala Glu Lys Met Lys Gln Val Ala Glu Glu
                2405                2410                2415    
Ala Ala Arg Leu Ser Val Ala Ala Gln Glu Ala Ala Arg Leu Arg Gln
            2420                2425                2430        
Leu Ala Glu Glu Asp Leu Ala Gln Gln Arg Ala Leu Ala Glu Lys Met
        2435                2440                2445            
Leu Lys Glu Lys Met Gln Ala Val Gln Glu Ala Thr Arg Leu Lys Ala
    2450                2455                2460                
Glu Ala Glu Leu Leu Gln Gln Gln Lys Glu Leu Ala Gln Glu Gln Ala
2465                2470                2475                2480
Arg Arg Leu Gln Glu Asp Lys Glu Gln Met Ala Gln Gln Leu Ala Glu
                2485                2490                2495    
Glu Thr Gln Gly Phe Gln Arg Thr Leu Glu Ala Glu Arg Gln Arg Gln
            2500                2505                2510        
Leu Glu Met Ser Ala Glu Ala Glu Arg Leu Lys Leu Arg Val Ala Glu
        2515                2520                2525            
Met Ser Arg Ala Gln Ala Arg Ala Glu Glu Asp Ala Gln Arg Phe Arg
    2530                2535                2540                
Lys Gln Ala Glu Glu Ile Gly Glu Lys Leu His Arg Thr Glu Leu Ala
2545                2550                2555                2560
Thr Gln Glu Lys Val Thr Leu Val Gln Thr Leu Glu Ile Gln Arg Gln
                2565                2570                2575    
Gln Ser Asp His Asp Ala Glu Arg Leu Arg Glu Ala Ile Ala Glu Leu
            2580                2585                2590        
Glu Arg Glu Lys Glu Lys Leu Gln Gln Glu Ala Lys Leu Leu Gln Leu
        2595                2600                2605            
Lys Ser Glu Glu Met Gln Thr Val Gln Gln Glu Gln Leu Leu Gln Glu
    2610                2615                2620                
Thr Gln Ala Leu Gln Gln Ser Phe Leu Ser Glu Lys Asp Ser Leu Leu
2625                2630                2635                2640
Gln Arg Glu Arg Phe Ile Glu Gln Glu Lys Ala Lys Leu Glu Gln Leu
                2645                2650                2655    
Phe Gln Asp Glu Val Ala Lys Ala Gln Gln Leu Arg Glu Glu Gln Gln
            2660                2665                2670        
Arg Gln Gln Gln Gln Met Glu Gln Glu Arg Gln Arg Leu Val Ala Ser
        2675                2680                2685            
Met Glu Glu Ala Arg Arg Arg Gln His Glu Ala Glu Glu Gly Val Arg
    2690                2695                2700                
Arg Lys Gln Glu Glu Leu Gln Gln Leu Glu Gln Gln Arg Arg Gln Gln
2705                2710                2715                2720
Glu Glu Leu Leu Ala Glu Glu Asn Gln Arg Leu Arg Glu Gln Leu Gln
                2725                2730                2735    
Leu Leu Glu Glu Gln His Arg Ala Ala Leu Ala His Ser Glu Glu Val
            2740                2745                2750        
Thr Ala Ser Gln Val Ala Ala Thr Lys Thr Leu Pro Asn Gly Arg Asp
        2755                2760                2765            
Ala Leu Asp Gly Pro Ala Ala Glu Ala Glu Pro Glu His Ser Phe Asp
    2770                2775                2780                
Gly Leu Arg Arg Lys Val Ser Ala Gln Arg Leu Gln Glu Ala Gly Ile
2785                2790                2795                2800
Leu Ser Ala Glu Glu Leu Gln Arg Leu Ala Gln Gly His Thr Thr Val
                2805                2810                2815    
Asp Glu Leu Ala Arg Arg Glu Asp Val Arg His Tyr Leu Gln Gly Arg
            2820                2825                2830        
Ser Ser Ile Ala Gly Leu Leu Leu Lys Ala Thr Asn Glu Lys Leu Ser
        2835                2840                2845            
Val Tyr Ala Ala Leu Gln Arg Gln Leu Leu Ser Pro Gly Thr Ala Leu
    2850                2855                2860                
Ile Leu Leu Glu Ala Gln Ala Ala Ser Gly Phe Leu Leu Asp Pro Val
2865                2870                2875                2880
Arg Asn Arg Arg Leu Thr Val Asn Glu Ala Val Lys Glu Gly Val Val
                2885                2890                2895    
Gly Pro Glu Leu His His Lys Leu Leu Ser Ala Glu Arg Ala Val Thr
            2900                2905                2910        
Gly Tyr Lys Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln Ala
        2915                2920                2925            
Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu Glu
    2930                2935                2940                
Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser His Arg
2945                2950                2955                2960
Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp Glu Glu Met
                2965                2970                2975    
Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp
            2980                2985                2990        
Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln Leu Leu Glu Arg Cys
        2995                3000                3005            
Val Glu Asp Pro Glu Thr Gly Leu Cys Leu Leu Pro Leu Thr Asp Lys
    3010                3015                3020                
Ala Ala Lys Gly Gly Glu Leu Val Tyr Thr Asp Ser Glu Ala Arg Asp
3025                3030                3035                3040
Val Phe Glu Lys Ala Thr Val Ser Ala Pro Phe Gly Lys Phe Gln Gly
                3045                3050                3055    
Lys Thr Val Thr Ile Trp Glu Ile Ile Asn Ser Glu Tyr Phe Thr Ala
            3060                3065                3070        
Glu Gln Arg Arg Asp Leu Leu Arg Gln Phe Arg Thr Gly Arg Ile Thr
        3075                3080                3085            
Val Glu Lys Ile Ile Lys Ile Ile Ile Thr Val Val Glu Glu Gln Glu
    3090                3095                3100                
Gln Lys Gly Arg Leu Cys Phe Glu Gly Leu Arg Ser Leu Val Pro Ala
3105                3110                3115                3120
Ala Glu Leu Leu Glu Ser Arg Val Ile Asp Arg Glu Leu Tyr Gln Gln
                3125                3130                3135    
Leu Gln Arg Gly Glu Arg Ser Val Arg Asp Val Ala Glu Val Asp Thr
            3140                3145                3150        
Val Arg Arg Ala Leu Arg Gly Ala Asn Val Ile Ala Gly Val Trp Leu
        3155                3160                3165            
Glu Glu Ala Gly Gln Lys Leu Ser Ile Tyr Asn Ala Leu Lys Lys Asp
    3170                3175                3180                
Leu Leu Pro Ser Asp Met Ala Val Ala Leu Leu Glu Ala Gln Ala Gly
3185                3190                3195                3200
Thr Gly His Ile Ile Asp Pro Ala Thr Ser Ala Arg Leu Thr Val Asp
                3205                3210                3215    
Glu Ala Val Arg Ala Gly Leu Val Gly Pro Glu Phe His Glu Lys Leu
            3220                3225                3230        
Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr Arg Asp Pro Tyr Thr Gly
        3235                3240                3245            
Gln Ser Val Ser Leu Phe Gln Ala Leu Lys Lys Gly Leu Ile Pro Arg
    3250                3255                3260                
Glu Gln Gly Leu Arg Leu Leu Asp Ala Gln Leu Ser Thr Gly Gly Ile
3265                3270                3275                3280
Val Asp Pro Ser Lys Ser His Arg Val Pro Leu Asp Val Ala Cys Ala
                3285                3290                3295    
Arg Gly Cys Leu Asp Glu Glu Thr Ser Arg Ala Leu Ser Glu Pro Arg
            3300                3305                3310        
Ala Asp Ala Lys Ala Tyr Ser Asp Pro Ser Thr Gly Glu Pro Ala Thr
        3315                3320                3325            
Tyr Gly Glu Leu Gln Gln Arg Cys Arg Pro Asp Gln Leu Thr Gly Leu
    3330                3335                3340                
Ser Leu Leu Pro Leu Ser Glu Lys Ala Ala Arg Ala Arg Gln Glu Glu
3345                3350                3355                3360
Phe Tyr Ser Glu Leu Gln Ala Arg Glu Thr Phe Glu Lys Thr Pro Val
                3365                3370                3375    
Glu Val Pro Val Gly Gly Phe Lys Gly Arg Thr Val Thr Val Trp Glu
            3380                3385                3390        
Leu Ile Ser Ser Glu Tyr Phe Thr Ala Glu Gln Arg Gln Glu Leu Phe
        3395                3400                3405            
Arg Gln Phe Arg Thr Gly Lys Val Thr Val Glu Lys Val Ile Lys Ile
    3410                3415                3420                
Leu Ile Thr Ile Val Glu Glu Val Glu Thr Leu Arg Gln Glu Arg Leu
3425                3430                3435                3440
Ser Phe Ser Gly Leu Arg Ser Pro Val Pro Ala Ser Glu Leu Leu Ala
                3445                3450                3455    
Ser Gly Val Leu Ser Arg Ala Gln Phe Glu Gln Leu Lys Asp Gly Lys
            3460                3465                3470        
Thr Thr Val Lys Asp Leu Ser Glu Leu Gly Ser Val Arg Thr Leu Leu
        3475                3480                3485            
Gln Gly Ser Gly Cys Leu Ala Gly Ile Tyr Leu Glu Asp Thr Lys Glu
    3490                3495                3500                
Lys Val Ser Ile Tyr Glu Ala Met Arg Arg Gly Leu Leu Arg Ala Thr
3505                3510                3515                3520
Thr Ala Ala Leu Leu Leu Glu Ala Gln Ala Gly Thr Gly Phe Leu Val
                3525                3530                3535    
Asp Pro Val Arg Asn Gln Arg Leu Tyr Val His Glu Ala Val Lys Ala
            3540                3545                3550        
Gly Val Val Gly Pro Glu Leu His Glu Gln Leu Leu Ser Ala Glu Lys
        3555                3560                3565            
Ala Val Thr Gly Tyr Arg Asp Pro Tyr Ser Gly Arg Thr Ile Ser Leu
    3570                3575                3580                
Phe Gln Ala Met Lys Lys Gly Leu Val Leu Arg Glu His Gly Ile Arg
3585                3590                3595                3600
Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro Val Asn
                3605                3610                3615    
Ser His Arg Val Pro Val Asp Val Ala Tyr Gln Arg Gly Tyr Phe Ser
            3620                3625                3630        
Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly
        3635                3640                3645            
Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Arg Gln Leu Leu
    3650                3655                3660                
Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Arg Leu Leu Pro Leu
3665                3670                3675                3680
Lys Gly Ala Glu Lys Val Glu Val Val Glu Thr Thr Gln Val Tyr Thr
                3685                3690                3695    
Glu Glu Glu Thr Arg Arg Ala Phe Glu Glu Thr Gln Ile Asp Ile Pro
            3700                3705                3710        
Gly Gly Gly Ser His Gly Gly Ser Thr Met Ser Leu Trp Glu Val Met
        3715                3720                3725            
Gln Ser Asp Leu Ile Pro Glu Glu Gln Arg Ala Gln Leu Met Ala Asp
    3730                3735                3740                
Phe Gln Ala Gly Arg Val Thr Lys Glu Arg Met Ile Ile Ile Ile Ile
3745                3750                3755                3760
Glu Ile Ile Glu Lys Thr Glu Ile Ile Arg Gln Gln Gly Leu Ala Ser
                3765                3770                3775    
Tyr Asp Tyr Val Arg Arg Arg Leu Thr Gly Glu Asp Leu Phe Glu Ala
            3780                3785                3790        
Arg Ile Ile Ser Leu Glu Thr Tyr Asn Leu Leu Arg Glu Gly Thr Lys
        3795                3800                3805            
Ser Leu Arg Glu Ala Leu Glu Gly Glu Ser Ala Trp Phe Tyr Leu Tyr
    3810                3815                3820                
Gly Thr Gly Ser Val Ala Gly Val Tyr Leu Pro Gly Ser Arg Gln Thr
3825                3830                3835                3840
Leu Ser Ile Tyr Gln Ala Leu Lys Lys Gly Leu Leu Ser Ala Glu Val
                3845                3850                3855    
Ala Arg Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Leu Leu Asp
            3860                3865                3870        
Pro Val Lys Gly Glu Arg Leu Thr Val Asp Glu Ala Val Arg Lys Gly
        3875                3880                3885            
Leu Val Gly Pro Glu Leu His Asp Arg Leu Leu Ser Ala Glu Arg Ala
    3890                3895                3900                
Val Thr Gly Tyr Arg Asp Pro Tyr Thr Glu Lys Thr Ile Ser Leu Phe
3905                3910                3915                3920
Gln Ala Met Lys Lys Glu Leu Ile Pro Thr Glu Glu Ala Leu Arg Leu
                3925                3930                3935    
Leu Asp Ala Gln Leu Ala Thr Gly Gly Ile Val Asp Pro Arg Leu Gly
            3940                3945                3950        
Phe His Leu Pro Leu Glu Val Ala Tyr Gln Arg Gly Tyr Leu Asn Lys
        3955                3960                3965            
Asp Thr His Asp Gln Leu Ser Glu Pro Ser Glu Val Arg Ser Tyr Val
    3970                3975                3980                
Asp Pro Ser Thr Asp Glu Arg Leu Ser Tyr Thr Gln Leu Leu Lys Arg
3985                3990                3995                4000
Cys Arg Arg Asp Asp Gly Ser Gly Gln Leu Leu Leu Pro Leu Ser Asp
                4005                4010                4015    
Ala Arg Lys Leu Thr Phe Arg Gly Leu Arg Lys Gln Ile Thr Met Glu
            4020                4025                4030        
Glu Leu Val Arg Ser Gln Val Met Asp Glu Ala Thr Ala Leu Gln Leu
        4035                4040                4045            
Arg Glu Gly Leu Thr Ser Ile Glu Glu Val Thr Lys Asn Leu Gln Lys
    4050                4055                4060                
Phe Leu Glu Gly Thr Ser Cys Ile Ala Gly Val Phe Val Asp Ala Thr
4065                4070                4075                4080
Lys Glu Arg Leu Ser Val Tyr Gln Ala Met Lys Lys Gly Ile Ile Arg
                4085                4090                4095    
Pro Gly Thr Ala Phe Glu Leu Leu Glu Ala Gln Ala Ala Thr Gly Tyr
            4100                4105                4110        
Val Ile Asp Pro Ile Lys Gly Leu Lys Leu Thr Val Glu Glu Ala Val
        4115                4120                4125            
Arg Met Gly Ile Val Gly Pro Glu Phe Lys Asp Lys Leu Leu Ser Ala
    4130                4135                4140                
Glu Arg Ala Val Thr Gly Tyr Lys Asp Pro Tyr Ser Gly Lys Leu Ile
4145                4150                4155                4160
Ser Leu Phe Gln Ala Met Lys Lys Gly Leu Ile Leu Lys Asp His Gly
                4165                4170                4175    
Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro
            4180                4185                4190        
Glu Glu Ser His Arg Leu Pro Val Glu Val Ala Tyr Lys Arg Gly Leu
        4195                4200                4205            
Phe Asp Glu Glu Met Asn Glu Ile Leu Thr Asp Pro Ser Asp Asp Thr
    4210                4215                4220                
Lys Gly Phe Phe Asp Pro Asn Thr Glu Glu Asn Leu Thr Tyr Leu Gln
4225                4230                4235                4240
Leu Met Glu Arg Cys Ile Thr Asp Pro Gln Thr Gly Leu Cys Leu Leu
                4245                4250                4255    
Pro Leu Lys Glu Lys Lys Arg Glu Arg Lys Thr Ser Ser Lys Ser Ser
            4260                4265                4270        
Val Arg Lys Arg Arg Val Val Ile Val Asp Pro Glu Thr Gly Lys Glu
        4275                4280                4285            
Met Ser Val Tyr Glu Ala Tyr Arg Lys Gly Leu Ile Asp His Gln Thr
    4290                4295                4300                
Tyr Leu Glu Leu Ser Glu Gln Glu Cys Glu Trp Glu Glu Ile Thr Ile
4305                4310                4315                4320
Ser Ser Ser Asp Gly Val Val Lys Ser Met Ile Ile Asp Arg Arg Ser
                4325                4330                4335    
Gly Arg Gln Tyr Asp Ile Asp Asp Ala Ile Ala Lys Asn Leu Ile Asp
            4340                4345                4350        
Arg Ser Ala Leu Asp Gln Tyr Arg Ala Gly Thr Leu Ser Ile Thr Glu
        4355                4360                4365            
Phe Ala Asp Met Leu Ser Gly Asn Ala Gly Gly Phe Arg Ser Arg Ser
    4370                4375                4380                
Ser Ser Val Gly Ser Ser Ser Ser Tyr Pro Ile Ser Pro Ala Val Ser
4385                4390                4395                4400
Arg Thr Gln Leu Ala Ser Trp Ser Asp Pro Thr Glu Glu Thr Gly Pro
                4405                4410                4415    
Val Ala Gly Ile Leu Asp Thr Glu Thr Leu Glu Lys Val Ser Ile Thr
            4420                4425                4430        
Glu Ala Met His Arg Asn Leu Val Asp Asn Ile Thr Gly Gln Arg Leu
        4435                4440                4445            
Leu Glu Ala Gln Ala Cys Thr Gly Gly Ile Ile Asp Pro Ser Thr Gly
    4450                4455                4460                
Glu Arg Leu Pro Val Thr Asp Ala Val Asn Lys Gly Leu Val Asp Lys
4465                4470                4475                4480
Ile Met Val Asp Arg Ile Asn Leu Ala Gln Lys Ala Phe Cys Gly Phe
                4485                4490                4495    
Glu Asp Pro Arg Thr Lys Thr Lys Met Ser Ala Ala Gln Ala Leu Lys
            4500                4505                4510        
Lys Gly Trp Leu Tyr Tyr Glu Ala Gly Gln Arg Phe Leu Glu Val Gln
        4515                4520                4525            
Tyr Leu Thr Gly Gly Leu Ile Glu Pro Asp Thr Pro Gly Arg Val Pro
    4530                4535                4540                
Leu Asp Glu Ala Leu Gln Arg Gly Thr Val Asp Ala Arg Thr Ala Gln
4545                4550                4555                4560
Lys Leu Arg Asp Val Gly Ala Tyr Ser Lys Tyr Leu Thr Cys Pro Lys
                4565                4570                4575    
Thr Lys Leu Lys Ile Ser Tyr Lys Asp Ala Leu Asp Arg Ser Met Val
            4580                4585                4590        
Glu Glu Gly Thr Gly Leu Arg Leu Leu Glu Ala Ala Ala Gln Ser Thr
        4595                4600                4605            
Lys Gly Tyr Tyr Ser Pro Tyr Ser Val Ser Gly Ser Gly Ser Thr Ala
    4610                4615                4620                
Gly Ser Arg Thr Gly Ser Arg Thr Gly Ser Arg Ala Gly Ser Arg Arg
4625                4630                4635                4640
Gly Ser Phe Asp Ala Thr Gly Ser Gly Phe Ser Met Thr Phe Ser Ser
                4645                4650                4655    
Ser Ser Tyr Ser Ser Ser Gly Tyr Gly Arg Arg Tyr Ala Ser Gly Ser
            4660                4665                4670        
Ser Ala Ser Leu Gly Gly Pro Glu Ser Ala Val Ala
        4675                4680                


<210> 7789
<211> 4570
<212> PRT
<213> Homo sapiens

<400> 7789
Met Ser Gly Glu Asp Ala Glu Val Arg Ala Val Ser Glu Asp Val Ser
 1               5                  10                  15      
Asn Gly Ser Ser Gly Ser Pro Ser Pro Gly Asp Thr Leu Pro Trp Asn
            20                  25                  30          
Leu Gly Lys Thr Gln Arg Ser Arg Arg Ser Gly Gly Gly Ala Gly Ser
        35                  40                  45              
Asn Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Ile Arg Ile Ala
    50                  55                  60                  
Asp Glu Arg Asp Arg Val Gln Lys Lys Thr Ser Thr Lys Trp Val Asn
65                  70                  75                  80  
Lys His Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp
                85                  90                  95      
Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly
            100                 105                 110         
Asp Ser Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln
        115                 120                 125             
Asn Val Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu
    130                 135                 140                 
Val Asn Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr
145                 150                 155                 160 
Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile
                165                 170                 175     
Gln Val Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu
            180                 185                 190         
Leu Trp Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp
        195                 200                 205             
Asn Phe Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile
    210                 215                 220                 
His Arg His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln
225                 230                 235                 240 
Thr Asn Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp
                245                 250                 255     
Leu Gly Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln
            260                 265                 270         
Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala
        275                 280                 285             
Met Pro Arg Val Pro Asp Val Gln Asp Gly Glu Leu Gln Leu Arg Trp
    290                 295                 300                 
Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp Met Arg His
305                 310                 315                 320 
His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser Phe Glu Glu
                325                 330                 335     
Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu Met Glu Leu
            340                 345                 350         
Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile Tyr Gln Ser
        355                 360                 365             
Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro Pro Gly Tyr
    370                 375                 380                 
His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His Val Ala Ile
385                 390                 395                 400 
Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg Leu Glu Cys
                405                 410                 415     
Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly Leu Cys Glu
            420                 425                 430         
Glu Gln Leu His Gln Ala Asp Ala Leu Leu Gln Ser Asp Ile Arg Leu
        435                 440                 445             
Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val Glu Arg Asp
    450                 455                 460                 
Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn Asp Val Gln
465                 470                 475                 480 
Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met Tyr Arg Arg
                485                 490                 495     
Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr Glu Tyr Asn
            500                 505                 510         
Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln Val Ala Gln
        515                 520                 525             
Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu Asp Ser Thr
    530                 535                 540                 
Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu Asn Gln His
545                 550                 555                 560 
Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser Val Glu Ala
                565                 570                 575     
Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu Glu Phe Gln
            580                 585                 590         
Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu Ser Pro Ala
        595                 600                 605             
Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp Leu Gln Tyr
    610                 615                 620                 
Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser Leu Glu Ser
625                 630                 635                 640 
Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met Trp Leu Asn
                645                 650                 655     
Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp Arg Asn Thr
            660                 665                 670         
Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met Arg Glu Leu
        675                 680                 685             
Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala Gly Asp Arg
    690                 695                 700                 
Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu Ser Phe Gln
705                 710                 715                 720 
Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys Cys Cys
                725                 730                 735     
Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Ser
            740                 745                 750         
Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu Ala Leu
        755                 760                 765             
Arg Arg Lys Asn Ser Cys Asp Arg Ser Ala Thr Val Thr Arg Leu Glu
    770                 775                 780                 
Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn Glu Tyr
785                 790                 795                 800 
Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val Val Gln
                805                 810                 815     
Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu Pro Leu
            820                 825                 830         
Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His Lys Gly
        835                 840                 845             
Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp Lys Val
    850                 855                 860                 
Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys Phe Leu
865                 870                 875                 880 
Val Pro Pro Pro Asn Gln Glu Val Gln Glu Ala Val Thr Arg Leu Glu
                885                 890                 895     
Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln Leu His Val Asp
            900                 905                 910         
Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg Asp Val Gln Leu
        915                 920                 925             
Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr Leu Lys Pro Glu Glu
    930                 935                 940                 
Gln Arg Gln Ala Leu His Ser Leu Glu Leu His Tyr Gln Ala Phe Leu
945                 950                 955                 960 
Arg Asp Ser Gln Asp Ala Gly Gly Phe Gly Pro Glu Asp Arg Leu Met
                965                 970                 975     
Ala Glu Arg Glu Tyr Gly Ser Cys Ser His His Tyr Gln Gln Leu Leu
            980                 985                 990         
Gln Ser Leu Glu Gln Gly Ala Gln Glu Glu Ser Arg Cys Gln Arg Cys
        995                 1000                1005            
Ile Ser Glu Leu Lys Asp Ile Arg Leu Gln Leu Glu Ala Cys Glu Thr
    1010                1015                1020                
Arg Thr Val His Arg Leu Arg Leu Pro Leu Asp Lys Glu Pro Ala Arg
1025                1030                1035                1040
Glu Cys Ala Gln Arg Ile Ala Glu Gln Gln Lys Ala Gln Ala Glu Val
                1045                1050                1055    
Glu Gly Leu Gly Lys Gly Val Ala Arg Leu Ser Ala Glu Ala Glu Lys
            1060                1065                1070        
Val Leu Ala Leu Pro Glu Pro Ser Pro Ala Ala Pro Thr Leu Arg Ser
        1075                1080                1085            
Glu Leu Glu Leu Thr Leu Gly Lys Leu Glu Gln Val Arg Ser Leu Ser
    1090                1095                1100                
Ala Ile Tyr Leu Glu Lys Leu Lys Thr Ile Ser Leu Val Ile Arg Gly
1105                1110                1115                1120
Thr Gln Gly Ala Glu Glu Val Leu Arg Ala His Glu Glu Gln Leu Lys
                1125                1130                1135    
Glu Ala Gln Ala Val Pro Ala Thr Leu Pro Glu Leu Glu Ala Thr Lys
            1140                1145                1150        
Ala Ser Leu Lys Lys Leu Arg Ala Gln Ala Glu Ala Gln Gln Pro Thr
        1155                1160                1165            
Phe Asp Ala Leu Arg Asp Glu Leu Arg Gly Ala Gln Glu Val Gly Glu
    1170                1175                1180                
Arg Leu Gln Gln Arg His Gly Glu Arg Asp Val Glu Val Glu Arg Trp
1185                1190                1195                1200
Arg Glu Arg Val Ala Gln Leu Leu Glu Arg Trp Gln Ala Val Leu Ala
                1205                1210                1215    
Gln Thr Asp Val Arg Gln Arg Glu Leu Glu Gln Leu Gly Arg Gln Leu
            1220                1225                1230        
Arg Tyr Tyr Arg Glu Ser Ala Asp Pro Leu Gly Ala Trp Leu Gln Asp
        1235                1240                1245            
Ala Arg Arg Arg Gln Glu Gln Ile Gln Ala Met Pro Leu Ala Asp Ser
    1250                1255                1260                
Gln Ala Val Arg Glu Gln Leu Arg Gln Glu Gln Ala Leu Leu Glu Glu
1265                1270                1275                1280
Ile Glu Arg His Gly Glu Lys Val Glu Glu Cys Gln Arg Phe Ala Lys
                1285                1290                1295    
Gln Tyr Ile Asn Ala Ile Lys Asp Tyr Glu Leu Gln Leu Val Thr Tyr
            1300                1305                1310        
Lys Ala Gln Leu Glu Pro Val Ala Ser Pro Ala Lys Lys Pro Lys Val
        1315                1320                1325            
Gln Ser Gly Ser Glu Ser Val Ile Gln Glu Tyr Val Asp Leu Arg Thr
    1330                1335                1340                
His Tyr Ser Glu Leu Thr Thr Leu Thr Ser Gln Tyr Ile Lys Phe Ile
1345                1350                1355                1360
Ser Glu Thr Leu Arg Arg Met Glu Glu Glu Glu Arg Leu Ala Glu Gln
                1365                1370                1375    
Gln Arg Ala Glu Glu Arg Glu Arg Leu Ala Glu Val Glu Ala Ala Leu
            1380                1385                1390        
Glu Lys Gln Arg Gln Leu Ala Glu Ala His Ala Gln Ala Lys Ala Gln
        1395                1400                1405            
Ala Glu Arg Glu Ala Lys Glu Leu Gln Gln Arg Ile Gln Glu Glu Val
    1410                1415                1420                
Val Arg Arg Glu Glu Ala Ala Val Asp Ala Gln Gln Gln Lys Arg Ser
1425                1430                1435                1440
Ile Gln Glu Glu Leu Gln Gln Leu Arg Gln Ser Ser Glu Ala Glu Ile
                1445                1450                1455    
Gln Ala Lys Ala Arg Gln Ala Glu Ala Ala Glu Arg Ser Arg Leu Arg
            1460                1465                1470        
Ile Glu Glu Glu Ile Arg Val Val Arg Leu Gln Leu Glu Ala Thr Glu
        1475                1480                1485            
Arg Gln Arg Gly Gly Ala Glu Gly Glu Leu Gln Ala Leu Arg Ala Arg
    1490                1495                1500                
Ala Glu Glu Ala Glu Ala Gln Lys Arg Gln Ala Gln Glu Glu Ala Glu
1505                1510                1515                1520
Arg Leu Arg Arg Gln Val Gln Asp Glu Ser Gln Arg Lys Arg Gln Ala
                1525                1530                1535    
Glu Val Glu Leu Ala Ser Arg Val Lys Ala Glu Ala Glu Ala Ala Arg
            1540                1545                1550        
Glu Lys Gln Arg Ala Leu Gln Ala Leu Glu Glu Leu Arg Leu Gln Ala
        1555                1560                1565            
Glu Glu Ala Glu Arg Trp Leu Cys Gln Ala Glu Val Glu Arg Ala Arg
    1570                1575                1580                
Gln Val Gln Val Ala Leu Glu Thr Ala Gln Arg Ser Ala Glu Ala Glu
1585                1590                1595                1600
Leu Gln Ser Lys Arg Ala Ser Phe Ala Glu Lys Thr Ala Gln Leu Glu
                1605                1610                1615    
Arg Ser Leu Gln Glu Glu His Val Ala Val Ala Gln Leu Arg Glu Glu
            1620                1625                1630        
Ala Glu Arg Arg Ala Gln Gln Gln Ala Glu Ala Glu Arg Ala Arg Glu
        1635                1640                1645            
Glu Ala Glu Arg Gln Leu Glu Arg Trp Gln Leu Lys Ala Asn Glu Ala
    1650                1655                1660                
Leu Arg Leu Arg Leu Gln Ala Glu Glu Val Leu Gln Gln Lys Ser Leu
1665                1670                1675                1680
Ala Gln Ala Glu Ala Glu Lys Gln Lys Glu Glu Ala Glu Arg Glu Ala
                1685                1690                1695    
Arg Arg Arg Gly Lys Ala Glu Glu Gln Ala Val Arg Gln Arg Glu Leu
            1700                1705                1710        
Ala Glu Gln Glu Leu Glu Lys Gln Arg Gln Leu Ala Glu Gly Thr Ala
        1715                1720                1725            
Gln Gln Arg Leu Ala Ala Glu Gln Glu Leu Ile Arg Leu Arg Ala Glu
    1730                1735                1740                
Thr Glu Gln Gly Glu Gln Gln Arg Gln Leu Leu Glu Glu Glu Leu Ala
1745                1750                1755                1760
Arg Leu Gln Arg Glu Ala Ala Ala Ala Thr Gln Lys Arg Gln Glu Leu
                1765                1770                1775    
Glu Ala Glu Leu Ala Lys Val Arg Ala Glu Met Glu Val Leu Leu Ala
            1780                1785                1790        
Ser Lys Ala Lys Ala Glu Glu Glu Ser Arg Ser Thr Ser Glu Lys Ser
        1795                1800                1805            
Lys Gln Arg Leu Glu Ala Glu Ala Gly Arg Phe Arg Glu Leu Ala Glu
    1810                1815                1820                
Glu Ala Ala Arg Leu Arg Ala Leu Ala Glu Glu Ala Lys Arg Gln Arg
1825                1830                1835                1840
Gln Leu Ala Glu Glu Asp Ala Ala Arg Gln Arg Ala Glu Ala Glu Arg
                1845                1850                1855    
Val Leu Ala Glu Lys Leu Ala Ala Ile Gly Glu Ala Thr Arg Leu Lys
            1860                1865                1870        
Thr Glu Ala Glu Ile Ala Leu Lys Glu Lys Glu Ala Glu Asn Glu Arg
        1875                1880                1885            
Leu Arg Arg Leu Ala Glu Asp Glu Ala Phe Gln Arg Arg Arg Leu Glu
    1890                1895                1900                
Glu Gln Ala Ala Gln His Lys Ala Asp Ile Glu Glu Arg Leu Ala Gln
1905                1910                1915                1920
Leu Arg Lys Ala Ser Asp Ser Glu Leu Glu Arg Gln Lys Gly Leu Val
                1925                1930                1935    
Glu Asp Thr Leu Arg Gln Arg Arg Gln Val Glu Glu Glu Ile Leu Ala
            1940                1945                1950        
Leu Lys Ala Ser Phe Glu Lys Ala Ala Ala Gly Lys Ala Glu Leu Glu
        1955                1960                1965            
Leu Glu Leu Gly Arg Ile Arg Ser Asn Ala Glu Asp Thr Leu Arg Ser
    1970                1975                1980                
Lys Glu Gln Ala Glu Leu Glu Ala Ala Arg Gln Arg Gln Leu Ala Ala
1985                1990                1995                2000
Glu Glu Glu Arg Arg Arg Arg Glu Ala Glu Glu Arg Val Gln Lys Ser
                2005                2010                2015    
Leu Ala Ala Glu Glu Glu Ala Ala Arg Gln Arg Lys Ala Ala Leu Glu
            2020                2025                2030        
Glu Val Glu Arg Leu Lys Ala Lys Val Glu Glu Ala Arg Ser Leu Arg
        2035                2040                2045            
Glu Arg Ala Glu Gln Glu Ser Ala Arg Gln Leu Gln Leu Ala Gln Glu
    2050                2055                2060                
Ala Ala Gln Lys Arg Leu Gln Ala Glu Glu Lys Ala His Ala Phe Ala
2065                2070                2075                2080
Val Gln Gln Lys Glu Gln Glu Leu Gln Gln Thr Leu Gln Gln Glu Gln
                2085                2090                2095    
Ser Val Leu Asp Arg Leu Arg Gly Glu Ala Glu Ala Ala Arg Arg Ala
            2100                2105                2110        
Ala Glu Glu Ala Glu Glu Ala Arg Val Gln Ala Glu Arg Glu Ala Ala
        2115                2120                2125            
Gln Ser Arg Arg Gln Val Glu Glu Ala Glu Arg Leu Lys Gln Ser Ala
    2130                2135                2140                
Glu Glu Gln Ala Gln Ala Arg Ala Gln Ala Gln Ala Ala Ala Glu Lys
2145                2150                2155                2160
Leu Arg Lys Glu Ala Glu Gln Glu Ala Ala Arg Arg Ala Gln Ala Glu
                2165                2170                2175    
Gln Ala Ala Leu Arg Gln Lys Gln Ala Ala Asp Ala Glu Met Glu Lys
            2180                2185                2190        
His Lys Lys Phe Ala Glu Gln Thr Leu Arg Gln Lys Ala Gln Val Glu
        2195                2200                2205            
Gln Glu Leu Thr Thr Leu Arg Leu Gln Leu Glu Glu Thr Asp His Gln
    2210                2215                2220                
Lys Asn Leu Leu Asp Glu Glu Leu Gln Arg Leu Lys Ala Glu Ala Thr
2225                2230                2235                2240
Glu Ala Ala Arg Gln Arg Ser Gln Val Glu Glu Glu Leu Phe Ser Val
                2245                2250                2255    
Arg Val Gln Met Glu Glu Leu Ser Lys Leu Lys Ala Arg Ile Glu Ala
            2260                2265                2270        
Glu Asn Arg Ala Leu Ile Leu Arg Asp Lys Asp Asn Thr Gln Arg Phe
        2275                2280                2285            
Leu Gln Glu Glu Ala Glu Lys Met Lys Gln Val Ala Glu Glu Ala Ala
    2290                2295                2300                
Arg Leu Ser Val Ala Ala Gln Glu Ala Ala Arg Leu Arg Gln Leu Ala
2305                2310                2315                2320
Glu Glu Asp Leu Ala Gln Gln Arg Ala Leu Ala Glu Lys Met Leu Lys
                2325                2330                2335    
Glu Lys Met Gln Ala Val Gln Glu Ala Thr Arg Leu Lys Ala Glu Ala
            2340                2345                2350        
Glu Leu Leu Gln Gln Gln Lys Glu Leu Ala Gln Glu Gln Ala Arg Arg
        2355                2360                2365            
Leu Gln Glu Asp Lys Glu Gln Met Ala Gln Gln Leu Ala Glu Glu Thr
    2370                2375                2380                
Gln Gly Phe Gln Arg Thr Leu Glu Ala Glu Arg Gln Arg Gln Leu Glu
2385                2390                2395                2400
Met Ser Ala Glu Ala Glu Arg Leu Lys Leu Arg Val Ala Glu Met Ser
                2405                2410                2415    
Arg Ala Gln Ala Arg Ala Glu Glu Asp Ala Gln Arg Phe Arg Lys Gln
            2420                2425                2430        
Ala Glu Glu Ile Gly Glu Lys Leu His Arg Thr Glu Leu Ala Thr Gln
        2435                2440                2445            
Glu Lys Val Thr Leu Val Gln Thr Leu Glu Ile Gln Arg Gln Gln Ser
    2450                2455                2460                
Asp His Asp Ala Glu Arg Leu Arg Glu Ala Ile Ala Glu Leu Glu Arg
2465                2470                2475                2480
Glu Lys Glu Lys Leu Gln Gln Glu Ala Lys Leu Leu Gln Leu Lys Ser
                2485                2490                2495    
Glu Glu Met Gln Thr Val Gln Gln Glu Gln Leu Leu Gln Glu Thr Gln
            2500                2505                2510        
Ala Leu Gln Gln Ser Phe Leu Ser Glu Lys Asp Ser Leu Leu Gln Arg
        2515                2520                2525            
Glu Arg Phe Ile Glu Gln Glu Lys Ala Lys Leu Glu Gln Leu Phe Gln
    2530                2535                2540                
Asp Glu Val Ala Lys Ala Gln Gln Leu Arg Glu Glu Gln Gln Arg Gln
2545                2550                2555                2560
Gln Gln Gln Met Glu Gln Glu Arg Gln Arg Leu Val Ala Ser Met Glu
                2565                2570                2575    
Glu Ala Arg Arg Arg Gln His Glu Ala Glu Glu Gly Val Arg Arg Lys
            2580                2585                2590        
Gln Glu Glu Leu Gln Gln Leu Glu Gln Gln Arg Arg Gln Gln Glu Glu
        2595                2600                2605            
Leu Leu Ala Glu Glu Asn Gln Arg Leu Arg Glu Gln Leu Gln Leu Leu
    2610                2615                2620                
Glu Glu Gln His Arg Ala Ala Leu Ala His Ser Glu Glu Val Thr Ala
2625                2630                2635                2640
Ser Gln Val Ala Ala Thr Lys Thr Leu Pro Asn Gly Arg Asp Ala Leu
                2645                2650                2655    
Asp Gly Pro Ala Ala Glu Ala Glu Pro Glu His Ser Phe Asp Gly Leu
            2660                2665                2670        
Arg Arg Lys Val Ser Ala Gln Arg Leu Gln Glu Ala Gly Ile Leu Ser
        2675                2680                2685            
Ala Glu Glu Leu Gln Arg Leu Ala Gln Gly His Thr Thr Val Asp Glu
    2690                2695                2700                
Leu Ala Arg Arg Glu Asp Val Arg His Tyr Leu Gln Gly Arg Ser Ser
2705                2710                2715                2720
Ile Ala Gly Leu Leu Leu Lys Ala Thr Asn Glu Lys Leu Ser Val Tyr
                2725                2730                2735    
Ala Ala Leu Gln Arg Gln Leu Leu Ser Pro Gly Thr Ala Leu Ile Leu
            2740                2745                2750        
Leu Glu Ala Gln Ala Ala Ser Gly Phe Leu Leu Asp Pro Val Arg Asn
        2755                2760                2765            
Arg Arg Leu Thr Val Asn Glu Ala Val Lys Glu Gly Val Val Gly Pro
    2770                2775                2780                
Glu Leu His His Lys Leu Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr
2785                2790                2795                2800
Lys Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln Ala Met Gln
                2805                2810                2815    
Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu Glu Ala Gln
            2820                2825                2830        
Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser His Arg Val Pro
        2835                2840                2845            
Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp Glu Glu Met Asn Arg
    2850                2855                2860                
Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn
2865                2870                2875                2880
Thr His Glu Asn Leu Thr Tyr Leu Gln Leu Leu Glu Arg Cys Val Glu
                2885                2890                2895    
Asp Pro Glu Thr Gly Leu Cys Leu Leu Pro Leu Thr Asp Lys Ala Ala
            2900                2905                2910        
Lys Gly Gly Glu Leu Val Tyr Thr Asp Ser Glu Ala Arg Asp Val Phe
        2915                2920                2925            
Glu Lys Ala Thr Val Ser Ala Pro Phe Gly Lys Phe Gln Gly Lys Thr
    2930                2935                2940                
Val Thr Ile Trp Glu Ile Ile Asn Ser Glu Tyr Phe Thr Ala Glu Gln
2945                2950                2955                2960
Arg Arg Asp Leu Leu Arg Gln Phe Arg Thr Gly Arg Ile Thr Val Glu
                2965                2970                2975    
Lys Ile Ile Lys Ile Ile Ile Thr Val Val Glu Glu Gln Glu Gln Lys
            2980                2985                2990        
Gly Arg Leu Cys Phe Glu Gly Leu Arg Ser Leu Val Pro Ala Ala Glu
        2995                3000                3005            
Leu Leu Glu Ser Arg Val Ile Asp Arg Glu Leu Tyr Gln Gln Leu Gln
    3010                3015                3020                
Arg Gly Glu Arg Ser Val Arg Asp Val Ala Glu Val Asp Thr Val Arg
3025                3030                3035                3040
Arg Ala Leu Arg Gly Ala Asn Val Ile Ala Gly Val Trp Leu Glu Glu
                3045                3050                3055    
Ala Gly Gln Lys Leu Ser Ile Tyr Asn Ala Leu Lys Lys Asp Leu Leu
            3060                3065                3070        
Pro Ser Asp Met Ala Val Ala Leu Leu Glu Ala Gln Ala Gly Thr Gly
        3075                3080                3085            
His Ile Ile Asp Pro Ala Thr Ser Ala Arg Leu Thr Val Asp Glu Ala
    3090                3095                3100                
Val Arg Ala Gly Leu Val Gly Pro Glu Phe His Glu Lys Leu Leu Ser
3105                3110                3115                3120
Ala Glu Lys Ala Val Thr Gly Tyr Arg Asp Pro Tyr Thr Gly Gln Ser
                3125                3130                3135    
Val Ser Leu Phe Gln Ala Leu Lys Lys Gly Leu Ile Pro Arg Glu Gln
            3140                3145                3150        
Gly Leu Arg Leu Leu Asp Ala Gln Leu Ser Thr Gly Gly Ile Val Asp
        3155                3160                3165            
Pro Ser Lys Ser His Arg Val Pro Leu Asp Val Ala Cys Ala Arg Gly
    3170                3175                3180                
Cys Leu Asp Glu Glu Thr Ser Arg Ala Leu Ser Glu Pro Arg Ala Asp
3185                3190                3195                3200
Ala Lys Ala Tyr Ser Asp Pro Ser Thr Gly Glu Pro Ala Thr Tyr Gly
                3205                3210                3215    
Glu Leu Gln Gln Arg Cys Arg Pro Asp Gln Leu Thr Gly Leu Ser Leu
            3220                3225                3230        
Leu Pro Leu Ser Glu Lys Ala Ala Arg Ala Arg Gln Glu Glu Phe Tyr
        3235                3240                3245            
Ser Glu Leu Gln Ala Arg Glu Thr Phe Glu Lys Thr Pro Val Glu Val
    3250                3255                3260                
Pro Val Gly Gly Phe Lys Gly Arg Thr Val Thr Val Trp Glu Leu Ile
3265                3270                3275                3280
Ser Ser Glu Tyr Phe Thr Ala Glu Gln Arg Gln Glu Leu Phe Arg Gln
                3285                3290                3295    
Phe Arg Thr Gly Lys Val Thr Val Glu Lys Val Ile Lys Ile Leu Ile
            3300                3305                3310        
Thr Ile Val Glu Glu Val Glu Thr Leu Arg Gln Glu Arg Leu Ser Phe
        3315                3320                3325            
Ser Gly Leu Arg Ser Pro Val Pro Ala Ser Glu Leu Leu Ala Ser Gly
    3330                3335                3340                
Val Leu Ser Arg Ala Gln Phe Glu Gln Leu Lys Asp Gly Lys Thr Thr
3345                3350                3355                3360
Val Lys Asp Leu Ser Glu Leu Gly Ser Val Arg Thr Leu Leu Gln Gly
                3365                3370                3375    
Ser Gly Cys Leu Ala Gly Ile Tyr Leu Glu Asp Thr Lys Glu Lys Val
            3380                3385                3390        
Ser Ile Tyr Glu Ala Met Arg Arg Gly Leu Leu Arg Ala Thr Thr Ala
        3395                3400                3405            
Ala Leu Leu Leu Glu Ala Gln Ala Gly Thr Gly Phe Leu Val Asp Pro
    3410                3415                3420                
Val Arg Asn Gln Arg Leu Tyr Val His Glu Ala Val Lys Ala Gly Val
3425                3430                3435                3440
Val Gly Pro Glu Leu His Glu Gln Leu Leu Ser Ala Glu Lys Ala Val
                3445                3450                3455    
Thr Gly Tyr Arg Asp Pro Tyr Ser Gly Arg Thr Ile Ser Leu Phe Gln
            3460                3465                3470        
Ala Met Lys Lys Gly Leu Val Leu Arg Glu His Gly Ile Arg Leu Leu
        3475                3480                3485            
Glu Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro Val Asn Ser His
    3490                3495                3500                
Arg Val Pro Val Asp Val Ala Tyr Gln Arg Gly Tyr Phe Ser Glu Glu
3505                3510                3515                3520
Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe
                3525                3530                3535    
Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Arg Gln Leu Leu Glu Arg
            3540                3545                3550        
Cys Val Glu Asp Pro Glu Thr Gly Leu Arg Leu Leu Pro Leu Lys Gly
        3555                3560                3565            
Ala Glu Lys Val Glu Val Val Glu Thr Thr Gln Val Tyr Thr Glu Glu
    3570                3575                3580                
Glu Thr Arg Arg Ala Phe Glu Glu Thr Gln Ile Asp Ile Pro Gly Gly
3585                3590                3595                3600
Gly Ser His Gly Gly Ser Thr Met Ser Leu Trp Glu Val Met Gln Ser
                3605                3610                3615    
Asp Leu Ile Pro Glu Glu Gln Arg Ala Gln Leu Met Ala Asp Phe Gln
            3620                3625                3630        
Ala Gly Arg Val Thr Lys Glu Arg Met Ile Ile Ile Ile Ile Glu Ile
        3635                3640                3645            
Ile Glu Lys Thr Glu Ile Ile Arg Gln Gln Gly Leu Ala Ser Tyr Asp
    3650                3655                3660                
Tyr Val Arg Arg Arg Leu Thr Gly Glu Asp Leu Phe Glu Ala Arg Ile
3665                3670                3675                3680
Ile Ser Leu Glu Thr Tyr Asn Leu Leu Arg Glu Gly Thr Lys Ser Leu
                3685                3690                3695    
Arg Glu Ala Leu Glu Gly Glu Ser Ala Trp Phe Tyr Leu Tyr Gly Thr
            3700                3705                3710        
Gly Ser Val Ala Gly Val Tyr Leu Pro Gly Ser Arg Gln Thr Leu Ser
        3715                3720                3725            
Ile Tyr Gln Ala Leu Lys Lys Gly Leu Leu Ser Ala Glu Val Ala Arg
    3730                3735                3740                
Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Leu Leu Asp Pro Val
3745                3750                3755                3760
Lys Gly Glu Arg Leu Thr Val Asp Glu Ala Val Arg Lys Gly Leu Val
                3765                3770                3775    
Gly Pro Glu Leu His Asp Arg Leu Leu Ser Ala Glu Arg Ala Val Thr
            3780                3785                3790        
Gly Tyr Arg Asp Pro Tyr Thr Glu Lys Thr Ile Ser Leu Phe Gln Ala
        3795                3800                3805            
Met Lys Lys Glu Leu Ile Pro Thr Glu Glu Ala Leu Arg Leu Leu Asp
    3810                3815                3820                
Ala Gln Leu Ala Thr Gly Gly Ile Val Asp Pro Arg Leu Gly Phe His
3825                3830                3835                3840
Leu Pro Leu Glu Val Ala Tyr Gln Arg Gly Tyr Leu Asn Lys Asp Thr
                3845                3850                3855    
His Asp Gln Leu Ser Glu Pro Ser Glu Val Arg Ser Tyr Val Asp Pro
            3860                3865                3870        
Ser Thr Asp Glu Arg Leu Ser Tyr Thr Gln Leu Leu Lys Arg Cys Arg
        3875                3880                3885            
Arg Asp Asp Gly Ser Gly Gln Leu Leu Leu Pro Leu Ser Asp Ala Arg
    3890                3895                3900                
Lys Leu Thr Phe Arg Gly Leu Arg Lys Gln Ile Thr Met Glu Glu Leu
3905                3910                3915                3920
Val Arg Ser Gln Val Met Asp Glu Ala Thr Ala Leu Gln Leu Arg Glu
                3925                3930                3935    
Gly Leu Thr Ser Ile Glu Glu Val Thr Lys Asn Leu Gln Lys Phe Leu
            3940                3945                3950        
Glu Gly Thr Ser Cys Ile Ala Gly Val Phe Val Asp Ala Thr Lys Glu
        3955                3960                3965            
Arg Leu Ser Val Tyr Gln Ala Met Lys Lys Gly Ile Ile Arg Pro Gly
    3970                3975                3980                
Thr Ala Phe Glu Leu Leu Glu Ala Gln Ala Ala Thr Gly Tyr Val Ile
3985                3990                3995                4000
Asp Pro Ile Lys Gly Leu Lys Leu Thr Val Glu Glu Ala Val Arg Met
                4005                4010                4015    
Gly Ile Val Gly Pro Glu Phe Lys Asp Lys Leu Leu Ser Ala Glu Arg
            4020                4025                4030        
Ala Val Thr Gly Tyr Lys Asp Pro Tyr Ser Gly Lys Leu Ile Ser Leu
        4035                4040                4045            
Phe Gln Ala Met Lys Lys Gly Leu Ile Leu Lys Asp His Gly Ile Arg
    4050                4055                4060                
Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro Glu Glu
4065                4070                4075                4080
Ser His Arg Leu Pro Val Glu Val Ala Tyr Lys Arg Gly Leu Phe Asp
                4085                4090                4095    
Glu Glu Met Asn Glu Ile Leu Thr Asp Pro Ser Asp Asp Thr Lys Gly
            4100                4105                4110        
Phe Phe Asp Pro Asn Thr Glu Glu Asn Leu Thr Tyr Leu Gln Leu Met
        4115                4120                4125            
Glu Arg Cys Ile Thr Asp Pro Gln Thr Gly Leu Cys Leu Leu Pro Leu
    4130                4135                4140                
Lys Glu Lys Lys Arg Glu Arg Lys Thr Ser Ser Lys Ser Ser Val Arg
4145                4150                4155                4160
Lys Arg Arg Val Val Ile Val Asp Pro Glu Thr Gly Lys Glu Met Ser
                4165                4170                4175    
Val Tyr Glu Ala Tyr Arg Lys Gly Leu Ile Asp His Gln Thr Tyr Leu
            4180                4185                4190        
Glu Leu Ser Glu Gln Glu Cys Glu Trp Glu Glu Ile Thr Ile Ser Ser
        4195                4200                4205            
Ser Asp Gly Val Val Lys Ser Met Ile Ile Asp Arg Arg Ser Gly Arg
    4210                4215                4220                
Gln Tyr Asp Ile Asp Asp Ala Ile Ala Lys Asn Leu Ile Asp Arg Ser
4225                4230                4235                4240
Ala Leu Asp Gln Tyr Arg Ala Gly Thr Leu Ser Ile Thr Glu Phe Ala
                4245                4250                4255    
Asp Met Leu Ser Gly Asn Ala Gly Gly Phe Arg Ser Arg Ser Ser Ser
            4260                4265                4270        
Val Gly Ser Ser Ser Ser Tyr Pro Ile Ser Pro Ala Val Ser Arg Thr
        4275                4280                4285            
Gln Leu Ala Ser Trp Ser Asp Pro Thr Glu Glu Thr Gly Pro Val Ala
    4290                4295                4300                
Gly Ile Leu Asp Thr Glu Thr Leu Glu Lys Val Ser Ile Thr Glu Ala
4305                4310                4315                4320
Met His Arg Asn Leu Val Asp Asn Ile Thr Gly Gln Arg Leu Leu Glu
                4325                4330                4335    
Ala Gln Ala Cys Thr Gly Gly Ile Ile Asp Pro Ser Thr Gly Glu Arg
            4340                4345                4350        
Leu Pro Val Thr Asp Ala Val Asn Lys Gly Leu Val Asp Lys Ile Met
        4355                4360                4365            
Val Asp Arg Ile Asn Leu Ala Gln Lys Ala Phe Cys Gly Phe Glu Asp
    4370                4375                4380                
Pro Arg Thr Lys Thr Lys Met Ser Ala Ala Gln Ala Leu Lys Lys Gly
4385                4390                4395                4400
Trp Leu Tyr Tyr Glu Ala Gly Gln Arg Phe Leu Glu Val Gln Tyr Leu
                4405                4410                4415    
Thr Gly Gly Leu Ile Glu Pro Asp Thr Pro Gly Arg Val Pro Leu Asp
            4420                4425                4430        
Glu Ala Leu Gln Arg Gly Thr Val Asp Ala Arg Thr Ala Gln Lys Leu
        4435                4440                4445            
Arg Asp Val Gly Ala Tyr Ser Lys Tyr Leu Thr Cys Pro Lys Thr Lys
    4450                4455                4460                
Leu Lys Ile Ser Tyr Lys Asp Ala Leu Asp Arg Ser Met Val Glu Glu
4465                4470                4475                4480
Gly Thr Gly Leu Arg Leu Leu Glu Ala Ala Ala Gln Ser Thr Lys Gly
                4485                4490                4495    
Tyr Tyr Ser Pro Tyr Ser Val Ser Gly Ser Gly Ser Thr Ala Gly Ser
            4500                4505                4510        
Arg Thr Gly Ser Arg Thr Gly Ser Arg Ala Gly Ser Arg Arg Gly Ser
        4515                4520                4525            
Phe Asp Ala Thr Gly Ser Gly Phe Ser Met Thr Phe Ser Ser Ser Ser
    4530                4535                4540                
Tyr Ser Ser Ser Gly Tyr Gly Arg Arg Tyr Ala Ser Gly Ser Ser Ala
4545                4550                4555                4560
Ser Leu Gly Gly Pro Glu Ser Ala Val Ala
                4565                4570


<210> 7790
<211> 586
<212> PRT
<213> Homo sapiens

<400> 7790
Met Ala Thr Ala Thr Pro Val Pro Pro Arg Met Gly Ser Arg Ala Gly
 1               5                  10                  15      
Gly Pro Thr Thr Pro Leu Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu
            20                  25                  30          
Lys Glu Glu Leu Arg Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp
        35                  40                  45              
Lys Val Arg Ser Leu Glu Thr Glu Asn Ser Ala Leu Gln Leu Gln Val
    50                  55                  60                  
Thr Glu Arg Glu Glu Val Arg Gly Arg Glu Leu Thr Gly Leu Lys Ala
65                  70                  75                  80  
Leu Tyr Glu Thr Glu Leu Ala Asp Ala Arg Arg Ala Leu Asp Asp Thr
                85                  90                  95      
Ala Arg Glu Arg Ala Lys Leu Gln Ile Glu Leu Gly Lys Cys Lys Ala
            100                 105                 110         
Glu His Asp Gln Leu Leu Leu Asn Tyr Ala Lys Lys Glu Ser Asp Leu
        115                 120                 125             
Asn Gly Ala Gln Ile Lys Leu Arg Glu Tyr Glu Ala Ala Leu Asn Ser
    130                 135                 140                 
Lys Asp Ala Ala Leu Ala Thr Ala Leu Gly Asp Lys Lys Ser Leu Glu
145                 150                 155                 160 
Gly Asp Leu Glu Asp Leu Lys Asp Gln Ile Ala Gln Leu Glu Ala Ser
                165                 170                 175     
Leu Ala Ala Ala Lys Lys Gln Leu Ala Asp Glu Thr Leu Leu Lys Val
            180                 185                 190         
Asp Leu Glu Asn Arg Cys Gln Ser Leu Thr Glu Asp Leu Glu Phe Arg
        195                 200                 205             
Lys Ser Met Tyr Glu Glu Glu Ile Asn Glu Thr Arg Arg Lys His Glu
    210                 215                 220                 
Thr Arg Leu Val Glu Val Asp Ser Gly Arg Gln Ile Glu Tyr Glu Tyr
225                 230                 235                 240 
Lys Leu Ala Gln Ala Leu His Glu Met Arg Glu Gln His Asp Ala Gln
                245                 250                 255     
Val Arg Leu Tyr Lys Glu Glu Leu Glu Gln Thr Tyr His Ala Lys Leu
            260                 265                 270         
Glu Asn Ala Arg Leu Ser Ser Glu Met Asn Thr Ser Thr Val Asn Ser
        275                 280                 285             
Ala Arg Glu Glu Leu Met Glu Ser Arg Met Arg Ile Glu Ser Leu Ser
    290                 295                 300                 
Ser Gln Leu Ser Asn Leu Gln Lys Glu Ser Arg Ala Cys Leu Glu Arg
305                 310                 315                 320 
Ile Gln Glu Leu Glu Asp Leu Leu Ala Lys Glu Lys Asp Asn Ser Arg
                325                 330                 335     
Arg Met Leu Thr Asp Lys Glu Arg Glu Met Ala Glu Ile Arg Asp Gln
            340                 345                 350         
Met Gln Gln Gln Leu Asn Asp Tyr Glu Gln Leu Leu Asp Val Lys Leu
        355                 360                 365             
Ala Leu Asp Met Glu Ile Ser Ala Tyr Arg Lys Leu Leu Glu Gly Glu
    370                 375                 380                 
Glu Glu Arg Leu Lys Leu Ser Pro Ser Pro Ser Ser Arg Val Thr Val
385                 390                 395                 400 
Ser Arg Ala Ser Ser Ser Arg Ser Val Arg Thr Thr Arg Gly Lys Arg
                405                 410                 415     
Lys Arg Val Asp Val Glu Glu Ser Glu Ala Ser Ser Ser Val Ser Ile
            420                 425                 430         
Ser His Ser Ala Ser Ala Thr Gly Asn Val Cys Ile Glu Glu Ile Asp
        435                 440                 445             
Val Asp Gly Lys Phe Ile Arg Leu Lys Asn Thr Ser Glu Gln Asp Gln
    450                 455                 460                 
Pro Met Gly Gly Trp Glu Met Ile Arg Lys Ile Gly Asp Thr Ser Val
465                 470                 475                 480 
Ser Tyr Lys Tyr Thr Ser Arg Tyr Val Leu Lys Ala Gly Gln Thr Val
                485                 490                 495     
Thr Ile Trp Ala Ala Asn Ala Gly Val Thr Ala Ser Pro Pro Thr Asp
            500                 505                 510         
Leu Ile Trp Lys Asn Gln Asn Ser Trp Gly Thr Gly Glu Asp Val Lys
        515                 520                 525             
Val Ile Leu Lys Asn Ser Gln Gly Glu Glu Val Ala Gln Arg Ser Thr
    530                 535                 540                 
Val Phe Lys Thr Thr Ile Pro Glu Glu Glu Glu Glu Glu Glu Glu Ala
545                 550                 555                 560 
Ala Gly Val Val Val Glu Glu Glu Leu Phe His Gln Gln Gly Thr Pro
                565                 570                 575     
Arg Ala Ser Asn Arg Ser Cys Ala Ile Met
            580                 585     


<210> 7791
<211> 527
<212> PRT
<213> Homo sapiens

<400> 7791
Val Leu Val Ile Ser Val Ala Phe Gln Tyr Thr Arg Leu Phe Ile Phe
 1               5                  10                  15      
Ser Pro Phe Gln Lys Lys Arg Pro Gln Ala Ser Glu Ile Asn Gln Leu
            20                  25                  30          
Ala Asn Leu Cys Gln Ile Pro Leu Glu Ile Cys Leu Pro Lys Thr Leu
        35                  40                  45              
Leu Thr Gly Glu Glu Gln Glu Met Asn Asn Ser Gln Gly Arg Val Thr
    50                  55                  60                  
Phe Glu Asp Val Thr Val Asn Phe Thr Gln Gly Glu Trp Gln Arg Leu
65                  70                  75                  80  
Asn Pro Glu Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr
                85                  90                  95      
Ser Asn Leu Val Ser Val Gly Gln Gly Glu Thr Thr Lys Pro Asp Val
            100                 105                 110         
Ile Leu Arg Leu Glu Gln Gly Lys Glu Pro Trp Leu Glu Glu Glu Glu
        115                 120                 125             
Val Leu Gly Ser Gly Arg Ala Glu Lys Asn Gly Asp Ile Gly Gly Gln
    130                 135                 140                 
Ile Trp Lys Pro Lys Asp Val Lys Glu Ser Leu Ala Arg Glu Val Pro
145                 150                 155                 160 
Ser Ile Asn Lys Glu Thr Leu Thr Thr Gln Lys Gly Val Glu Cys Asp
                165                 170                 175     
Gly Ser Lys Lys Ile Leu Pro Leu Gly Ile Asp Asp Val Ser Ser Leu
            180                 185                 190         
Gln His Tyr Val Gln Asn Asn Ser His Asp Asp Asn Gly Tyr Arg Lys
        195                 200                 205             
Leu Val Gly Asn Asn Pro Ser Lys Phe Val Gly Gln Gln Leu Lys Cys
    210                 215                 220                 
Asn Ala Cys Arg Lys Leu Phe Ser Ser Lys Ser Arg Leu Gln Ser His
225                 230                 235                 240 
Leu Arg Arg His Ala Cys Gln Lys Pro Phe Glu Cys His Ser Cys Gly
                245                 250                 255     
Arg Ala Phe Gly Glu Lys Trp Lys Leu Asp Lys His Gln Lys Thr His
            260                 265                 270         
Ala Glu Glu Arg Pro Tyr Lys Cys Glu Asn Cys Gly Asn Ala Tyr Lys
        275                 280                 285             
Gln Lys Ser Asn Leu Phe Gln His Gln Lys Met His Thr Lys Glu Lys
    290                 295                 300                 
Pro Tyr Gln Cys Lys Thr Cys Gly Lys Ala Phe Ser Trp Lys Ser Ser
305                 310                 315                 320 
Cys Ile Asn His Glu Lys Ile His Asn Ala Lys Lys Ser Tyr Gln Cys
                325                 330                 335     
Asn Glu Cys Glu Lys Ser Phe Arg Gln Asn Ser Thr Leu Ile Gln His
            340                 345                 350         
Lys Lys Val His Thr Gly Gln Lys Pro Phe Gln Cys Thr Asp Cys Gly
        355                 360                 365             
Lys Ala Phe Ile Tyr Lys Ser Asp Leu Val Lys His Gln Arg Ile His
    370                 375                 380                 
Thr Gly Glu Lys Pro Tyr Lys Cys Ser Ile Cys Glu Lys Ala Phe Ser
385                 390                 395                 400 
Gln Lys Ser Asn Val Ile Asp His Glu Lys Ile His Thr Gly Lys Arg
                405                 410                 415     
Ala Tyr Glu Cys Asp Leu Cys Gly Asn Thr Phe Ile Gln Lys Lys Asn
            420                 425                 430         
Leu Ile Gln His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys
        435                 440                 445             
Asn Arg Cys Gly Lys Ala Phe Phe Gln Lys Ser Asn Leu His Ser His
    450                 455                 460                 
Gln Lys Thr His Ser Gly Glu Arg Thr Tyr Arg Cys Ser Glu Cys Gly
465                 470                 475                 480 
Lys Thr Phe Ile Arg Lys Leu Asn Leu Ser Leu His Lys Lys Thr His
                485                 490                 495     
Thr Gly Gln Lys Pro Tyr Gly Cys Ser Glu Cys Gly Lys Ala Phe Ala
            500                 505                 510         
Asp Arg Ser Tyr Leu Val Arg His Gln Lys Arg Ile His Ser Arg
        515                 520                 525         


<210> 7792
<211> 164
<212> PRT
<213> Homo sapiens

<400> 7792
Met Asn Asn Ser Leu Asp Tyr Leu Ala Tyr Pro Val Ile Val Ser Asn
 1               5                  10                  15      
His Arg Gln Ser Thr Thr Phe Arg Lys Lys Leu Asp Phe Gly His Tyr
            20                  25                  30          
Val Ser His Lys Asn Arg Ile Gln Ile Ala Lys Pro Thr Val Asp Thr
        35                  40                  45              
Lys Pro Pro Val Ala His Thr Asn His Ile Leu Lys Leu Ser Lys Leu
    50                  55                  60                  
Gln Gly Glu Gln Lys Lys Ile Asn Lys Ile Glu Tyr Glu Asn Lys Gln
65                  70                  75                  80  
Leu Cys Gln Lys Ile Ala Asn Ala His Arg Gly Pro Ala Lys Val Asp
                85                  90                  95      
Cys Trp Asn Glu Tyr Phe Ser Lys Ser Leu Asn Arg Glu Thr Arg Asn
            100                 105                 110         
Arg Glu Leu Val Arg Ile Thr Met Glu Asn Gln Gly Ile Leu Lys Arg
        115                 120                 125             
Leu Val Asp Arg Lys Pro His Tyr Asp Arg Arg Ala Ser Glu Ile Asp
    130                 135                 140                 
Trp Gln Asn Ser Arg Arg Tyr Ile Arg Asn Thr Thr Arg Tyr Leu Leu
145                 150                 155                 160 
Ser Gln Asn Glu
                


<210> 7793
<211> 763
<212> PRT
<213> Homo sapiens

<400> 7793
Met Glu Lys Glu Glu Glu Ser Glu His His Leu Gln Arg Ala Ile Ser
 1               5                  10                  15      
Ala Gln Gln Val Phe Arg Glu Lys Lys Glu Ser Met Val Ile Pro Val
            20                  25                  30          
Pro Glu Ala Glu Ser Asn Val Asn Tyr Tyr Asn Arg Leu Tyr Lys Gly
        35                  40                  45              
Glu Phe Lys Gln Pro Lys Gln Phe Ile His Ile Gln Pro Phe Asn Leu
    50                  55                  60                  
Asp Asn Glu Gln Pro Asp Tyr Asp Met Asp Ser Glu Asp Glu Thr Leu
65                  70                  75                  80  
Leu Asn Arg Leu Asn Arg Lys Met Glu Ile Lys Pro Leu Gln Phe Glu
                85                  90                  95      
Ile Met Ile Asp Arg Leu Glu Lys Ala Ser Ser Asn Gln Leu Val Thr
            100                 105                 110         
Leu Gln Glu Ala Lys Leu Leu Leu Asn Glu Asp Asp Tyr Leu Ile Lys
        115                 120                 125             
Ala Val Tyr Asp Tyr Trp Val Arg Lys Arg Lys Asn Cys Arg Gly Pro
    130                 135                 140                 
Ser Leu Ile Pro Gln Ile Lys Gln Glu Lys Arg Asp Gly Ser Thr Asn
145                 150                 155                 160 
Asn Asp Pro Tyr Val Ala Phe Arg Arg Arg Thr Glu Lys Met Gln Thr
                165                 170                 175     
Arg Lys Asn Arg Lys Asn Asp Glu Ala Ser Tyr Glu Lys Met Leu Lys
            180                 185                 190         
Leu Arg Arg Glu Phe Ser Arg Ala Ile Thr Ile Leu Glu Met Ile Lys
        195                 200                 205             
Arg Arg Glu Lys Thr Lys Arg Glu Leu Leu His Leu Thr Leu Glu Val
    210                 215                 220                 
Val Glu Lys Arg Tyr His Leu Gly Asp Tyr Gly Gly Glu Ile Leu Asn
225                 230                 235                 240 
Glu Val Lys Ile Ser Arg Ser Glu Lys Glu Leu Tyr Ala Thr Pro Ala
                245                 250                 255     
Thr Leu His Asn Gly Asn His His Lys Val Gln Glu Cys Lys Thr Lys
            260                 265                 270         
His Pro His His Leu Ser Leu Lys Glu Glu Ala Ser Asp Val Val Arg
        275                 280                 285             
Gln Lys Lys Lys Tyr Pro Lys Lys Pro Lys Ala Glu Ala Leu Ile Thr
    290                 295                 300                 
Ser Gln Gln Pro Thr Pro Glu Thr Leu Pro Val Ile Asn Lys Ser Asp
305                 310                 315                 320 
Ile Lys Gln Tyr Asp Phe His Ser Ser Asp Glu Asp Glu Phe Pro Gln
                325                 330                 335     
Val Leu Ser Pro Val Ser Glu Pro Glu Glu Glu Asn Asp Pro Asp Gly
            340                 345                 350         
Pro Cys Ala Phe Arg Arg Arg Ala Gly Cys Gln Tyr Tyr Ala Pro Arg
        355                 360                 365             
Leu Asp Gln Ala Asn His Ser Cys Glu Asn Ser Glu Leu Ala Asp Leu
    370                 375                 380                 
Asp Lys Leu Arg Tyr Arg His Cys Leu Thr Thr Leu Thr Val Pro Arg
385                 390                 395                 400 
Arg Cys Ile Gly Phe Ala Arg Arg Arg Ile Gly Arg Gly Gly Arg Val
                405                 410                 415     
Ile Met Asp Arg Ile Ser Thr Glu His Asp Pro Val Leu Lys Gln Ile
            420                 425                 430         
Asp Pro Glu Met Leu Asn Ser Phe Ser Ser Ser Ser Gln Thr Ile Asp
        435                 440                 445             
Phe Ser Ser Asn Phe Ser Arg Thr Asn Ala Ser Ser Lys His Cys Glu
    450                 455                 460                 
Asn Arg Leu Ser Leu Ser Glu Ile Leu Ser Asn Ile Arg Ser Cys Arg
465                 470                 475                 480 
Leu Gln Cys Phe Gln Pro Arg Leu Leu Asn Leu Gln Asp Ser Asp Ser
                485                 490                 495     
Glu Glu Cys Thr Ser Arg Lys Pro Gly Gln Thr Val Asn Asn Lys Arg
            500                 505                 510         
Val Ser Ala Ala Ser Val Ala Leu Leu Asn Thr Ser Lys Asn Gly Ile
        515                 520                 525             
Ser Val Thr Gly Gly Ile Thr Glu Glu Gln Phe Gln Thr His Gln Gln
    530                 535                 540                 
Gln Leu Val Gln Met Gln Arg Gln Gln Leu Ala Gln Leu Gln Gln Lys
545                 550                 555                 560 
Gln Gln Ser Gln His Ser Ser Gln Gln Thr His Pro Lys Ala Gln Gly
                565                 570                 575     
Ser Ser Thr Ser Asp Cys Met Ser Lys Thr Leu Asp Ser Ala Ser Ala
            580                 585                 590         
His Phe Ala Ala Ser Ala Val Val Ser Ala Pro Val Pro Ser Arg Ser
        595                 600                 605             
Glu Val Ala Lys Glu Gln Asn Thr Gly His Asn Asn Ile Asn Gly Val
    610                 615                 620                 
Val Gln Pro Ser Gly Thr Ser Lys Thr Leu Tyr Ser Thr Asn Met Ala
625                 630                 635                 640 
Leu Ser Ser Ser Pro Gly Ile Ser Ala Val Gln Leu Val Arg Thr Val
                645                 650                 655     
Gly His Thr Thr Thr Asn His Leu Ile Pro Ala Leu Cys Thr Ser Ser
            660                 665                 670         
Pro Gln Thr Leu Pro Met Asn Asn Ser Cys Leu Thr Asn Ala Val His
        675                 680                 685             
Leu Asn Asn Val Ser Val Val Ser Pro Val Asn Val His Ile Asn Thr
    690                 695                 700                 
Arg Thr Ser Ala Pro Ser Pro Thr Ala Leu Lys Leu Ala Thr Val Ala
705                 710                 715                 720 
Ala Ser Met Asp Arg Val Pro Lys Val Thr Pro Ser Ser Ala Ile Ser
                725                 730                 735     
Ser Ile Ala Arg Glu Asn His Glu Pro Glu Arg Leu Gly Leu Asn Gly
            740                 745                 750         
Ile Ala Glu Thr Thr Val Ala Met Glu Val Thr
        755                 760             


<210> 7794
<211> 1799
<212> PRT
<213> Homo sapiens

<400> 7794
Glu Asn Phe His Cys Asp Leu Asn Ser Asp Gln Phe Lys Gly Phe Leu
 1               5                  10                  15      
Arg Ala His Thr Pro Ser Val Ala Ala Ser Ser Gln Ala Arg Ser Ala
            20                  25                  30          
Val Phe Ser Val Thr Tyr Pro Ser Ser Asp Ile Tyr Leu Val Val Lys
        35                  40                  45              
Ile Glu Lys Val Leu Gln Gln Gly Glu Ile Gly Asp Cys Ala Glu Pro
    50                  55                  60                  
Tyr Thr Val Ile Lys Glu Ser Asp Gly Gly Lys Ser Lys Glu Lys Ile
65                  70                  75                  80  
Glu Lys Leu Lys Leu Gln Ala Glu Ser Phe Cys Gln Arg Leu Gly Lys
                85                  90                  95      
Tyr Arg Met Pro Phe Ala Trp Ala Pro Ile Ser Leu Ser Ser Phe Phe
            100                 105                 110         
Asn Val Ser Thr Leu Glu Arg Glu Val Thr Asp Val Asp Ser Val Val
        115                 120                 125             
Gly Arg Ser Ser Val Gly Glu Arg Arg Thr Leu Ala Gln Ser Arg Arg
    130                 135                 140                 
Leu Ser Glu Arg Ala Leu Ser Leu Glu Glu Asn Gly Val Gly Ser Asn
145                 150                 155                 160 
Phe Lys Thr Ser Thr Leu Ser Val Ser Ser Phe Phe Lys Gln Glu Gly
                165                 170                 175     
Asp Arg Leu Ser Asp Glu Asp Leu Phe Lys Phe Leu Ala Asp Tyr Lys
            180                 185                 190         
Arg Ser Ser Ser Leu Gln Arg Arg Val Lys Ser Ile Pro Gly Leu Leu
        195                 200                 205             
Arg Leu Glu Ile Ser Thr Ala Pro Glu Ile Ile Asn Cys Cys Leu Thr
    210                 215                 220                 
Pro Glu Met Leu Pro Val Lys Pro Phe Pro Glu Asn Arg Thr Arg Pro
225                 230                 235                 240 
His Lys Glu Ile Leu Glu Phe Pro Thr Arg Glu Val Tyr Val Pro His
                245                 250                 255     
Thr Val Tyr Arg Asn Leu Leu Tyr Val Tyr Pro Gln Arg Leu Asn Phe
            260                 265                 270         
Val Asn Lys Leu Ala Ser Ala Arg Asn Ile Thr Ile Lys Ile Gln Phe
        275                 280                 285             
Met Cys Gly Glu Asp Ala Ser Asn Ala Met Pro Val Ile Phe Gly Lys
    290                 295                 300                 
Ser Ser Gly Pro Glu Phe Leu Gln Glu Val Tyr Thr Ala Val Thr Tyr
305                 310                 315                 320 
His Asn Lys Ser Pro Asp Phe Tyr Glu Glu Val Lys Ile Lys Leu Pro
                325                 330                 335     
Ala Lys Leu Thr Val Asn His His Leu Leu Phe Thr Phe Tyr His Ile
            340                 345                 350         
Ser Cys Gln Gln Lys Gln Gly Ala Ser Val Glu Thr Leu Leu Gly Tyr
        355                 360                 365             
Ser Trp Leu Pro Ile Leu Leu Asn Glu Arg Leu Gln Thr Gly Ser Tyr
    370                 375                 380                 
Cys Leu Pro Val Ala Leu Glu Lys Leu Pro Pro Asn Tyr Ser Met His
385                 390                 395                 400 
Ser Ala Glu Lys Val Pro Leu Gln Asn Pro Pro Ile Lys Trp Ala Glu
                405                 410                 415     
Gly His Lys Gly Val Phe Asn Ile Glu Val Gln Ala Val Ser Ser Val
            420                 425                 430         
His Thr Gln Asp Asn His Leu Glu Lys Phe Phe Thr Leu Cys His Ser
        435                 440                 445             
Leu Glu Ser Gln Val Thr Phe Pro Ile Arg Val Leu Asp Gln Lys Ile
    450                 455                 460                 
Ser Glu Met Ala Leu Glu His Glu Leu Lys Leu Ser Ile Ile Cys Leu
465                 470                 475                 480 
Asn Ser Ser Arg Leu Glu Pro Leu Val Leu Phe Leu His Leu Val Leu
                485                 490                 495     
Asp Lys Leu Phe Gln Leu Ser Val Gln Pro Met Val Ile Ala Gly Gln
            500                 505                 510         
Thr Ala Asn Phe Ser Gln Phe Ala Phe Glu Ser Val Val Ala Ile Ala
        515                 520                 525             
Asn Ser Leu His Asn Ser Lys Asp Leu Ser Lys Asp Gln His Gly Arg
    530                 535                 540                 
Asn Cys Leu Leu Ala Ser Tyr Val His Tyr Val Phe Arg Leu Pro Glu
545                 550                 555                 560 
Val Gln Arg Asp Val Pro Lys Ser Gly Ala Pro Thr Ala Leu Leu Asp
                565                 570                 575     
Pro Arg Ser Tyr His Thr Tyr Gly Arg Thr Ser Ala Ala Ala Val Ser
            580                 585                 590         
Ser Lys Leu Leu Gln Ala Arg Val Met Ser Ser Ser Asn Pro Asp Leu
        595                 600                 605             
Ala Gly Thr His Ser Ala Ala Asp Glu Glu Val Lys Asn Ile Met Ser
    610                 615                 620                 
Ser Lys Ile Ala Asp Arg Asn Cys Ser Arg Met Ser Tyr Tyr Cys Ser
625                 630                 635                 640 
Gly Ser Ser Asp Ala Pro Ser Ser Pro Ala Ala Pro Arg Pro Ala Ser
                645                 650                 655     
Lys Lys His Phe His Glu Glu Leu Ala Leu Gln Met Val Val Ser Thr
            660                 665                 670         
Gly Met Val Arg Glu Thr Val Phe Lys Tyr Ala Trp Phe Phe Phe Glu
        675                 680                 685             
Leu Leu Val Lys Ser Met Ala Gln His Val His Asn Met Asp Lys Arg
    690                 695                 700                 
Asp Ser Phe Arg Arg Thr Arg Phe Ser Asp Arg Phe Met Asp Asp Ile
705                 710                 715                 720 
Thr Thr Ile Val Asn Val Val Thr Ser Glu Ile Ala Ala Leu Leu Val
                725                 730                 735     
Lys Pro Gln Lys Glu Asn Glu Gln Ala Glu Lys Met Asn Ile Ser Leu
            740                 745                 750         
Ala Phe Phe Leu Tyr Asp Leu Leu Ser Leu Met Asp Arg Gly Phe Val
        755                 760                 765             
Phe Asn Leu Ile Arg His Tyr Cys Ser Gln Leu Ser Ala Lys Leu Ser
    770                 775                 780                 
Asn Leu Pro Thr Leu Ile Ser Met Arg Leu Glu Phe Leu Arg Ile Leu
785                 790                 795                 800 
Cys Ser His Glu His Tyr Leu Asn Leu Asn Leu Phe Phe Met Asn Ala
                805                 810                 815     
Asp Thr Ala Pro Thr Ser Pro Cys Pro Ser Ile Ser Ser Gln Asn Ser
            820                 825                 830         
Ser Ser Cys Ser Ser Phe Gln Asp Gln Lys Ile Ala Ser Met Phe Asp
        835                 840                 845             
Leu Thr Ser Glu Tyr Arg Gln Gln His Phe Leu Thr Gly Leu Leu Phe
    850                 855                 860                 
Thr Glu Leu Ala Ala Ala Leu Asp Ala Glu Gly Glu Gly Ile Ser Lys
865                 870                 875                 880 
Val Gln Arg Lys Ala Val Ser Ala Ile His Ser Leu Leu Ser Ser His
                885                 890                 895     
Asp Leu Asp Pro Arg Cys Val Lys Pro Glu Val Lys Val Lys Ile Ala
            900                 905                 910         
Ala Leu Tyr Leu Pro Leu Val Gly Ile Ile Leu Asp Ala Leu Pro Gln
        915                 920                 925             
Leu Cys Asp Phe Thr Val Ala Asp Thr Arg Arg Tyr Arg Thr Ser Gly
    930                 935                 940                 
Ser Asp Glu Glu Gln Glu Gly Ala Gly Ala Ile Asn Gln Asn Val Ala
945                 950                 955                 960 
Leu Ala Ile Ala Gly Asn Asn Phe Asn Leu Lys Thr Ser Gly Ile Val
                965                 970                 975     
Leu Ser Ser Leu Pro Tyr Lys Gln Tyr Asn Met Leu Asn Ala Asp Thr
            980                 985                 990         
Thr Arg Asn Leu Met Ile Cys Phe Leu Trp Ile Met Lys Asn Ala Asp
        995                 1000                1005            
Gln Ser Leu Ile Arg Lys Trp Ile Ala Asp Leu Pro Ser Thr Gln Leu
    1010                1015                1020                
Asn Arg Ile Leu Asp Leu Leu Phe Ile Cys Val Leu Cys Phe Glu Tyr
1025                1030                1035                1040
Lys Gly Lys Gln Ser Ser Asp Lys Val Ser Thr Gln Val Leu Gln Lys
                1045                1050                1055    
Ser Arg Asp Val Lys Ala Arg Leu Glu Glu Ala Leu Leu Arg Gly Glu
            1060                1065                1070        
Gly Ala Arg Gly Glu Met Met Arg Arg Arg Ala Pro Gly Asn Asp Arg
        1075                1080                1085            
Phe Pro Gly Leu Asn Glu Asn Leu Arg Trp Lys Lys Glu Gln Thr His
    1090                1095                1100                
Trp Arg Gln Ala Asn Glu Lys Leu Asp Lys Thr Lys Ala Glu Leu Asp
1105                1110                1115                1120
Gln Glu Ala Leu Ile Ser Gly Asn Leu Ala Thr Glu Ala His Leu Ile
                1125                1130                1135    
Ile Leu Asp Met Gln Glu Asn Ile Ile Gln Ala Ser Ser Ala Leu Asp
            1140                1145                1150        
Cys Lys Asp Ser Leu Leu Gly Gly Val Leu Arg Val Leu Val Asn Ser
        1155                1160                1165            
Leu Asn Cys Asp Gln Ser Thr Thr Tyr Leu Thr His Cys Phe Ala Thr
    1170                1175                1180                
Leu Arg Ala Leu Ile Ala Lys Phe Gly Asp Leu Leu Phe Glu Glu Glu
1185                1190                1195                1200
Val Glu Gln Cys Phe Asp Leu Cys His Gln Val Leu His His Cys Ser
                1205                1210                1215    
Ser Ser Met Asp Val Thr Arg Ser Gln Ala Cys Ala Thr Leu Tyr Leu
            1220                1225                1230        
Leu Met Arg Phe Ser Phe Gly Ala Thr Ser Asn Phe Ala Arg Val Lys
        1235                1240                1245            
Met Gln Val Thr Met Ser Leu Ala Ser Leu Val Gly Arg Ala Pro Asp
    1250                1255                1260                
Phe Asn Glu Glu His Leu Arg Arg Ser Leu Arg Thr Ile Leu Ala Tyr
1265                1270                1275                1280
Ser Glu Glu Asp Thr Ala Met Gln Met Thr Pro Phe Pro Thr Gln Val
                1285                1290                1295    
Glu Glu Leu Leu Cys Asn Leu Asn Ser Ile Leu Tyr Asp Thr Val Lys
            1300                1305                1310        
Met Arg Glu Phe Gln Glu Asp Pro Glu Met Leu Met Asp Leu Met Tyr
        1315                1320                1325            
Arg Ile Ala Lys Ser Tyr Gln Ala Ser Pro Asp Leu Arg Leu Thr Trp
    1330                1335                1340                
Leu Gln Asn Met Ala Glu Lys His Thr Lys Lys Lys Cys Tyr Thr Glu
1345                1350                1355                1360
Ala Ala Met Cys Leu Val His Ala Ala Ala Leu Val Ala Glu Tyr Leu
                1365                1370                1375    
Ser Met Leu Glu Asp His Ser Tyr Leu Pro Val Gly Ser Val Ser Phe
            1380                1385                1390        
Gln Asn Ile Ser Ser Asn Val Leu Glu Glu Ser Val Val Ser Glu Asp
        1395                1400                1405            
Thr Leu Ser Pro Asp Glu Asp Gly Val Cys Ala Gly Gln Tyr Phe Thr
    1410                1415                1420                
Glu Ser Gly Leu Val Gly Leu Leu Glu Gln Ala Ala Glu Leu Phe Ser
1425                1430                1435                1440
Thr Gly Gly Leu Tyr Glu Thr Val Asn Glu Val Tyr Lys Leu Val Ile
                1445                1450                1455    
Pro Ile Leu Glu Ala His Arg Glu Phe Arg Lys Leu Thr Leu Thr His
            1460                1465                1470        
Ser Lys Leu Gln Arg Ala Phe Asp Ser Ile Val Asn Lys Asp His Lys
        1475                1480                1485            
Arg Met Phe Gly Thr Tyr Phe Arg Val Gly Phe Phe Gly Ser Lys Phe
    1490                1495                1500                
Gly Asp Leu Asp Glu Gln Glu Phe Val Tyr Lys Glu Pro Ala Ile Thr
1505                1510                1515                1520
Lys Leu Pro Glu Ile Ser His Arg Leu Glu Ala Phe Tyr Gly Gln Cys
                1525                1530                1535    
Phe Gly Ala Glu Phe Val Glu Val Ile Lys Asp Ser Thr Pro Val Asp
            1540                1545                1550        
Lys Thr Lys Leu Asp Pro Asn Lys Ala Tyr Ile Gln Ile Thr Phe Val
        1555                1560                1565            
Glu Pro Tyr Phe Asp Glu Tyr Glu Met Lys Asp Arg Val Thr Tyr Phe
    1570                1575                1580                
Glu Lys Asn Phe Asn Leu Arg Arg Phe Met Tyr Thr Thr Pro Phe Thr
1585                1590                1595                1600
Leu Glu Gly Arg Pro Arg Gly Glu Leu His Glu Gln Tyr Arg Arg Asn
                1605                1610                1615    
Thr Val Leu Thr Thr Met His Ala Phe Pro Tyr Ile Lys Thr Arg Ile
            1620                1625                1630        
Ser Val Ile Gln Lys Glu Glu Phe Val Leu Thr Pro Ile Glu Val Ala
        1635                1640                1645            
Ile Glu Asp Met Lys Lys Lys Thr Leu Gln Leu Ala Val Ala Ile Asn
    1650                1655                1660                
Gln Glu Pro Pro Asp Ala Lys Met Leu Gln Met Val Leu Gln Gly Ser
1665                1670                1675                1680
Val Gly Ala Thr Val Asn Gln Gly Pro Leu Glu Val Ala Gln Val Phe
                1685                1690                1695    
Leu Ala Glu Ile Pro Ala Asp Pro Lys Leu Tyr Arg His His Asn Lys
            1700                1705                1710        
Leu Arg Leu Cys Phe Lys Glu Phe Ile Met Arg Cys Gly Glu Ala Val
        1715                1720                1725            
Glu Lys Asn Lys Arg Leu Ile Thr Ala Asp Gln Arg Glu Tyr Gln Gln
    1730                1735                1740                
Glu Leu Lys Lys Asn Tyr Asn Lys Leu Lys Glu Asn Leu Arg Pro Met
1745                1750                1755                1760
Ile Glu Arg Lys Ile Pro Glu Leu Tyr Lys Pro Ile Phe Arg Val Glu
                1765                1770                1775    
Ser Gln Lys Arg Asp Ser Phe His Arg Ser Ser Phe Arg Lys Cys Glu
            1780                1785                1790        
Thr Gln Leu Ser Gln Gly Ser
        1795                


<210> 7795
<211> 376
<212> PRT
<213> Homo sapiens

<400> 7795
Met Lys His Phe Lys Lys Glu Lys Ser Glu Ala Glu Asn His Ile Arg
 1               5                  10                  15      
Thr Leu Lys Ala Glu Ser Leu Glu Glu Lys Asn Met Ala Lys Ile His
            20                  25                  30          
Arg Gly Gln Leu Glu Lys Leu Lys Ser Gln Cys Asp Arg Leu Thr Glu
        35                  40                  45              
Glu Leu Thr Gln Asn Glu Asn Glu Asn Lys Lys Leu Lys Leu Lys Tyr
    50                  55                  60                  
Gln Cys Leu Lys Asp Gln Leu Glu Glu Arg Glu Lys His Ile Ser Ile
65                  70                  75                  80  
Glu Glu Glu His Leu Arg Arg Met Glu Glu Ala Arg Leu Gln Leu Lys
                85                  90                  95      
Asp Gln Leu Leu Cys Leu Glu Thr Glu Gln Glu Ser Ile Leu Gly Val
            100                 105                 110         
Ile Gly Lys Glu Ile Asp Ala Ala Cys Lys Thr Phe Ser Lys Asp Ser
        115                 120                 125             
Val Glu Lys Leu Lys Val Phe Ser Ser Gly Pro Asp Ile His Tyr Asp
    130                 135                 140                 
Pro His Arg Trp Leu Ala Glu Ser Lys Thr Lys Leu Gln Trp Leu Cys
145                 150                 155                 160 
Glu Glu Leu Lys Glu Arg Glu Asn Arg Glu Lys Asn Leu Arg His Gln
                165                 170                 175     
Leu Met Leu Cys Arg Gln Gln Leu Arg Asn Leu Thr Glu Asn Lys Glu
            180                 185                 190         
Ser Glu Leu Gln Cys Leu Phe Gln Gln Ile Glu Arg Gln Glu Gln Leu
        195                 200                 205             
Leu Asp Glu Ile His Arg Glu Lys Arg Asp Leu Leu Glu Glu Thr Gln
    210                 215                 220                 
Arg Lys Asp Glu Glu Met Gly Ser Leu Gln Asp Arg Val Ile Ala Leu
225                 230                 235                 240 
Glu Thr Ser Thr Gln Val Ala Leu Asp His Leu Glu Ser Val Ala Glu
                245                 250                 255     
Lys Leu Ser Leu Leu Glu Asp Phe Lys Asp Phe Arg Asp Ser Cys Ser
            260                 265                 270         
Ser Ser Glu Arg Thr Asp Gly Arg Tyr Ser Lys Tyr Arg Val Arg Arg
        275                 280                 285             
Asn Ser Leu Gln His His Gln Asp Asp Thr Lys Tyr Arg Thr Lys Ser
    290                 295                 300                 
Phe Lys Gly Asp Arg Thr Phe Leu Glu Gly Ser His Thr Arg Gly Leu
305                 310                 315                 320 
Asp His Ser Ser Ser Trp Gln Asp His Ser Arg Phe Leu Ser Ser Pro
                325                 330                 335     
Arg Phe Ser Tyr Val Asn Ser Phe Thr Lys Arg Thr Val Ala Pro Asp
            340                 345                 350         
Ser Ala Ser Asn Lys Glu Asp Ala Thr Met Asn Gly Thr Ser Ser Gln
        355                 360                 365             
Pro Lys Lys Glu Glu Tyr Gly Ser
    370                 375     


<210> 7796
<211> 2092
<212> PRT
<213> Homo sapiens

<400> 7796
Met Ser Gln Pro Pro Leu Leu Pro Ala Ser Ala Glu Thr Arg Lys Phe
 1               5                  10                  15      
Thr Arg Ala Leu Ser Lys Pro Gly Thr Ala Ala Glu Leu Arg Gln Ser
            20                  25                  30          
Val Ser Glu Val Val Arg Gly Ser Val Leu Leu Ala Lys Pro Lys Leu
        35                  40                  45              
Ile Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln
    50                  55                  60                  
Ile Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp
65                  70                  75                  80  
Phe Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr
                85                  90                  95      
Val Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu
            100                 105                 110         
Cys Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr
        115                 120                 125             
Glu Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys
    130                 135                 140                 
Leu Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp
145                 150                 155                 160 
Lys Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr
                165                 170                 175     
Lys His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val
            180                 185                 190         
Thr Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly
        195                 200                 205             
Asp Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys
    210                 215                 220                 
Glu Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln
225                 230                 235                 240 
Asn Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys
                245                 250                 255     
Ser Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp
            260                 265                 270         
Ile Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met
        275                 280                 285             
Gln Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys
    290                 295                 300                 
Leu Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala
305                 310                 315                 320 
Lys Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val
                325                 330                 335     
Lys Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser
            340                 345                 350         
Ala Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile
        355                 360                 365             
Leu Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala
    370                 375                 380                 
Glu Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr
385                 390                 395                 400 
Leu Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe
                405                 410                 415     
His Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr
            420                 425                 430         
Ser Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys
        435                 440                 445             
Gly Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe
    450                 455                 460                 
Ser Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu
465                 470                 475                 480 
Lys Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys
                485                 490                 495     
Ser Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys
            500                 505                 510         
Gln Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala
        515                 520                 525             
Ala Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala
    530                 535                 540                 
Arg Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp
545                 550                 555                 560 
Asp Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala
                565                 570                 575     
Lys Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val
            580                 585                 590         
Ser Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys
        595                 600                 605             
Gln Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu
    610                 615                 620                 
Phe Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr
625                 630                 635                 640 
Asn His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys
                645                 650                 655     
Ser Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp
            660                 665                 670         
Ser Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro
        675                 680                 685             
Gly Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His
    690                 695                 700                 
His Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr
705                 710                 715                 720 
Gln Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser
                725                 730                 735     
Cys Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu
            740                 745                 750         
Thr Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val
        755                 760                 765             
Val Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly
    770                 775                 780                 
Tyr Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu
785                 790                 795                 800 
Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His
                805                 810                 815     
Leu Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe
            820                 825                 830         
Gln Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu
        835                 840                 845             
Leu Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met
    850                 855                 860                 
Ile Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr
865                 870                 875                 880 
Arg Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile
                885                 890                 895     
His Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg
            900                 905                 910         
Ser Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu
        915                 920                 925             
Tyr Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu
    930                 935                 940                 
Lys Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser
945                 950                 955                 960 
Trp Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile
                965                 970                 975     
Glu Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser
            980                 985                 990         
Tyr His His Ala Val Glu Thr Val Val Asn Met Leu Met Pro His Ile
        995                 1000                1005            
Thr Gln Lys Phe Arg Asp Asn Pro Glu Ala Ser Lys Asn Ala Asn His
    1010                1015                1020                
Ser Leu Ala Val Phe Ile Lys Arg Cys Phe Thr Phe Met Asp Arg Gly
1025                1030                1035                1040
Phe Val Phe Lys Gln Ile Asn Asn Tyr Ile Ser Cys Phe Ala Pro Gly
                1045                1050                1055    
Asp Pro Lys Thr Leu Phe Glu Tyr Lys Phe Glu Phe Leu Arg Val Val
            1060                1065                1070        
Cys Asn His Glu His Tyr Ile Pro Leu Asn Leu Pro Met Pro Phe Gly
        1075                1080                1085            
Lys Gly Arg Ile Gln Arg Tyr Gln Asp Leu Gln Leu Asp Tyr Ser Leu
    1090                1095                1100                
Thr Asp Glu Phe Cys Arg Asn His Phe Leu Val Gly Leu Leu Leu Arg
1105                1110                1115                1120
Glu Val Gly Thr Ala Leu Gln Glu Phe Arg Glu Val Arg Leu Ile Ala
                1125                1130                1135    
Ile Ser Val Leu Lys Asn Leu Leu Ile Lys His Ser Phe Asp Asp Arg
            1140                1145                1150        
Tyr Ala Ser Arg Ser His Gln Ala Arg Ile Ala Thr Leu Tyr Leu Pro
        1155                1160                1165            
Leu Phe Gly Leu Leu Ile Glu Asn Val Gln Arg Ile Asn Val Arg Asp
    1170                1175                1180                
Val Ser Pro Phe Pro Val Asn Ala Gly Met Thr Val Lys Asp Glu Ser
1185                1190                1195                1200
Leu Ala Leu Pro Ala Val Asn Pro Leu Val Thr Pro Gln Lys Gly Ser
                1205                1210                1215    
Thr Leu Asp Asn Ser Leu His Lys Asp Leu Leu Gly Ala Ile Ser Gly
            1220                1225                1230        
Ile Ala Ser Pro Tyr Thr Thr Ser Thr Pro Asn Ile Asn Ser Val Arg
        1235                1240                1245            
Asn Ala Asp Ser Arg Gly Ser Leu Ile Ser Thr Asp Ser Gly Asn Ser
    1250                1255                1260                
Leu Pro Glu Arg Asn Ser Glu Lys Ser Asn Ser Leu Asp Lys His Gln
1265                1270                1275                1280
Gln Ser Ser Thr Leu Gly Asn Ser Val Val Arg Cys Asp Lys Leu Asp
                1285                1290                1295    
Gln Ser Glu Ile Lys Ser Leu Leu Met Cys Phe Leu Tyr Ile Leu Lys
            1300                1305                1310        
Ser Met Ser Asp Asp Ala Leu Phe Thr Tyr Trp Asn Lys Ala Ser Thr
        1315                1320                1325            
Ser Glu Leu Met Asp Phe Phe Thr Ile Ser Glu Val Cys Leu His Gln
    1330                1335                1340                
Phe Gln Tyr Met Gly Lys Arg Tyr Ile Ala Arg Asn Gln Glu Gly Leu
1345                1350                1355                1360
Gly Pro Ile Val His Asp Arg Lys Ser Gln Thr Leu Pro Val Ser Arg
                1365                1370                1375    
Asn Arg Thr Gly Met Met His Ala Arg Leu Gln Gln Leu Gly Ser Leu
            1380                1385                1390        
Asp Asn Ser Leu Thr Phe Asn His Ser Tyr Gly His Ser Asp Ala Asp
        1395                1400                1405            
Val Leu His Gln Ser Leu Leu Glu Ala Asn Ile Ala Thr Glu Val Cys
    1410                1415                1420                
Leu Thr Ala Leu Asp Thr Leu Ser Leu Phe Thr Leu Ala Phe Lys Asn
1425                1430                1435                1440
Gln Leu Leu Ala Asp His Gly His Asn Pro Leu Met Lys Lys Val Phe
                1445                1450                1455    
Asp Val Tyr Leu Cys Phe Leu Gln Lys His Gln Ser Glu Thr Ala Leu
            1460                1465                1470        
Lys Asn Val Phe Thr Ala Leu Arg Ser Leu Ile Tyr Lys Phe Pro Ser
        1475                1480                1485            
Thr Phe Tyr Glu Gly Arg Ala Asp Met Cys Ala Ala Leu Cys Tyr Glu
    1490                1495                1500                
Ile Leu Lys Cys Cys Asn Ser Lys Leu Ser Ser Ile Arg Thr Glu Ala
1505                1510                1515                1520
Ser Gln Leu Leu Tyr Phe Leu Met Arg Asn Asn Phe Asp Tyr Thr Gly
                1525                1530                1535    
Lys Lys Ser Phe Val Arg Thr His Leu Gln Val Ile Ile Ser Val Ser
            1540                1545                1550        
Gln Leu Ile Ala Asp Val Val Gly Ile Gly Gly Thr Arg Phe Gln Gln
        1555                1560                1565            
Ser Leu Ser Ile Ile Asn Asn Cys Ala Asn Ser Asp Arg Leu Ile Lys
    1570                1575                1580                
His Thr Ser Phe Ser Ser Asp Val Lys Asp Leu Thr Lys Arg Ile Arg
1585                1590                1595                1600
Thr Val Leu Met Ala Thr Ala Gln Met Lys Glu His Glu Asn Asp Pro
                1605                1610                1615    
Glu Met Leu Val Asp Leu Gln Tyr Ser Leu Ala Lys Ser Tyr Ala Ser
            1620                1625                1630        
Thr Pro Glu Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Arg Ile His
        1635                1640                1645            
Val Lys Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Val His Val
    1650                1655                1660                
Thr Ala Leu Val Ala Glu Tyr Leu Thr Arg Lys Glu Ala Val Gln Trp
1665                1670                1675                1680
Glu Pro Pro Leu Leu Pro His Ser His Ser Ala Cys Leu Arg Arg Ser
                1685                1690                1695    
Arg Gly Gly Val Phe Arg Gln Gly Cys Thr Ala Phe Arg Val Ile Thr
            1700                1705                1710        
Pro Asn Ile Asp Glu Glu Ala Ser Met Met Glu Asp Val Gly Met Gln
        1715                1720                1725            
Asp Val His Phe Asn Glu Asp Val Leu Met Glu Leu Leu Glu Gln Cys
    1730                1735                1740                
Ala Asp Gly Leu Trp Lys Ala Glu Arg Tyr Glu Leu Ile Ala Asp Ile
1745                1750                1755                1760
Tyr Lys Leu Ile Ile Pro Ile Tyr Glu Lys Arg Arg Asp Phe Glu Arg
                1765                1770                1775    
Leu Ala His Leu Tyr Asp Thr Leu His Arg Ala Tyr Ser Lys Val Thr
            1780                1785                1790        
Glu Val Met His Ser Gly Arg Arg Leu Leu Gly Thr Tyr Phe Arg Val
        1795                1800                1805            
Ala Phe Phe Gly Gln Ala Ala Gln Tyr Gln Phe Thr Asp Ser Glu Thr
    1810                1815                1820                
Asp Val Glu Gly Phe Phe Glu Asp Glu Asp Gly Lys Glu Tyr Ile Tyr
1825                1830                1835                1840
Lys Glu Pro Lys Leu Thr Pro Leu Ser Glu Ile Ser Gln Arg Leu Leu
                1845                1850                1855    
Lys Leu Tyr Ser Asp Lys Phe Gly Ser Glu Asn Val Lys Met Ile Gln
            1860                1865                1870        
Asp Ser Gly Lys Val Asn Pro Lys Asp Leu Asp Ser Lys Tyr Ala Tyr
        1875                1880                1885            
Ile Gln Val Thr His Val Ile Pro Phe Phe Asp Glu Lys Glu Leu Gln
    1890                1895                1900                
Glu Arg Lys Thr Glu Phe Glu Arg Ser His Asn Ile Arg Arg Phe Met
1905                1910                1915                1920
Phe Glu Met Pro Phe Thr Gln Thr Gly Lys Arg Gln Gly Gly Val Glu
                1925                1930                1935    
Glu Gln Cys Lys Arg Arg Thr Ile Leu Thr Ala Ile His Cys Phe Pro
            1940                1945                1950        
Tyr Val Lys Lys Arg Ile Pro Val Met Tyr Gln His His Thr Asp Leu
        1955                1960                1965            
Asn Pro Ile Glu Val Ala Ile Asp Glu Met Ser Lys Lys Val Ala Glu
    1970                1975                1980                
Leu Arg Gln Leu Cys Ser Ser Ala Glu Val Asp Met Ile Lys Leu Gln
1985                1990                1995                2000
Leu Lys Leu Gln Gly Ser Val Ser Val Gln Val Asn Ala Gly Pro Leu
                2005                2010                2015    
Ala Tyr Ala Arg Ala Phe Leu Asp Asp Thr Asn Thr Lys Arg Tyr Pro
            2020                2025                2030        
Asp Asn Lys Val Lys Leu Leu Lys Glu Val Phe Arg Gln Phe Val Glu
        2035                2040                2045            
Ala Cys Gly Gln Ala Leu Ala Val Asn Glu Arg Leu Ile Lys Glu Asp
    2050                2055                2060                
Gln Leu Glu Tyr Gln Glu Glu Met Lys Ala Asn Tyr Arg Glu Met Ala
2065                2070                2075                2080
Lys Glu Leu Ser Glu Ile Met His Glu Gln Leu Gly
                2085                2090        


<210> 7797
<211> 2093
<212> PRT
<213> Homo sapiens

<400> 7797
Met Ser Gln Pro Pro Leu Leu Pro Ala Ser Ala Glu Thr Arg Lys Phe
 1               5                  10                  15      
Thr Arg Ala Leu Ser Lys Pro Gly Thr Ala Ala Glu Leu Arg Gln Ser
            20                  25                  30          
Val Ser Glu Val Val Arg Gly Ser Val Leu Leu Ala Lys Pro Lys Leu
        35                  40                  45              
Ile Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln
    50                  55                  60                  
Ile Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp
65                  70                  75                  80  
Phe Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr
                85                  90                  95      
Val Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu
            100                 105                 110         
Cys Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr
        115                 120                 125             
Glu Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys
    130                 135                 140                 
Leu Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp
145                 150                 155                 160 
Lys Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr
                165                 170                 175     
Lys His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val
            180                 185                 190         
Thr Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly
        195                 200                 205             
Asp Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys
    210                 215                 220                 
Glu Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln
225                 230                 235                 240 
Asn Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys
                245                 250                 255     
Ser Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp
            260                 265                 270         
Ile Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met
        275                 280                 285             
Gln Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys
    290                 295                 300                 
Leu Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala
305                 310                 315                 320 
Lys Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val
                325                 330                 335     
Lys Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser
            340                 345                 350         
Ala Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile
        355                 360                 365             
Leu Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala
    370                 375                 380                 
Glu Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr
385                 390                 395                 400 
Leu Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe
                405                 410                 415     
His Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr
            420                 425                 430         
Ser Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys
        435                 440                 445             
Gly Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe
    450                 455                 460                 
Ser Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu
465                 470                 475                 480 
Lys Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys
                485                 490                 495     
Ser Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys
            500                 505                 510         
Gln Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala
        515                 520                 525             
Ala Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala
    530                 535                 540                 
Arg Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp
545                 550                 555                 560 
Asp Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala
                565                 570                 575     
Lys Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val
            580                 585                 590         
Ser Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys
        595                 600                 605             
Gln Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu
    610                 615                 620                 
Phe Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr
625                 630                 635                 640 
Asn His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys
                645                 650                 655     
Ser Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp
            660                 665                 670         
Ser Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro
        675                 680                 685             
Gly Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His
    690                 695                 700                 
His Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr
705                 710                 715                 720 
Gln Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser
                725                 730                 735     
Cys Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu
            740                 745                 750         
Thr Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val
        755                 760                 765             
Val Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly
    770                 775                 780                 
Tyr Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu
785                 790                 795                 800 
Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His
                805                 810                 815     
Leu Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe
            820                 825                 830         
Gln Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu
        835                 840                 845             
Leu Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met
    850                 855                 860                 
Ile Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr
865                 870                 875                 880 
Arg Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile
                885                 890                 895     
His Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg
            900                 905                 910         
Ser Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu
        915                 920                 925             
Tyr Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu
    930                 935                 940                 
Lys Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser
945                 950                 955                 960 
Trp Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile
                965                 970                 975     
Glu Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser
            980                 985                 990         
Tyr His His Ala Val Glu Thr Val Val Asn Met Leu Met Pro His Ile
        995                 1000                1005            
Thr Gln Lys Phe Arg Asp Asn Pro Glu Ala Ser Lys Asn Ala Asn His
    1010                1015                1020                
Ser Leu Ala Val Phe Ile Lys Arg Cys Phe Thr Phe Met Asp Arg Gly
1025                1030                1035                1040
Phe Val Phe Lys Gln Ile Asn Asn Tyr Ile Ser Cys Phe Ala Pro Gly
                1045                1050                1055    
Asp Pro Lys Thr Leu Phe Glu Tyr Lys Phe Glu Phe Leu Arg Val Val
            1060                1065                1070        
Cys Asn His Glu His Tyr Ile Pro Leu Asn Leu Pro Met Pro Phe Gly
        1075                1080                1085            
Lys Gly Arg Ile Gln Arg Tyr Gln Asp Leu Gln Leu Asp Tyr Ser Leu
    1090                1095                1100                
Thr Asp Glu Phe Cys Arg Asn His Phe Leu Val Gly Leu Leu Leu Arg
1105                1110                1115                1120
Glu Val Gly Thr Ala Leu Gln Glu Phe Arg Glu Val Arg Leu Ile Ala
                1125                1130                1135    
Ile Ser Val Leu Lys Asn Leu Leu Ile Lys His Ser Phe Asp Asp Arg
            1140                1145                1150        
Tyr Ala Ser Arg Ser His Gln Ala Arg Ile Ala Thr Leu Tyr Leu Pro
        1155                1160                1165            
Leu Phe Gly Leu Leu Ile Glu Asn Val Gln Arg Ile Asn Val Arg Asp
    1170                1175                1180                
Val Ser Pro Phe Pro Val Asn Ala Gly Met Thr Val Lys Asp Glu Ser
1185                1190                1195                1200
Leu Ala Leu Pro Ala Val Asn Pro Leu Val Thr Pro Gln Lys Gly Ser
                1205                1210                1215    
Thr Leu Asp Asn Ser Leu His Lys Asp Leu Leu Gly Ala Ile Ser Gly
            1220                1225                1230        
Ile Ala Ser Pro Tyr Thr Thr Ser Thr Pro Asn Ile Asn Ser Val Arg
        1235                1240                1245            
Asn Ala Asp Ser Arg Gly Ser Leu Ile Ser Thr Asp Ser Gly Asn Ser
    1250                1255                1260                
Leu Pro Glu Arg Asn Ser Glu Lys Ser Asn Ser Leu Asp Lys His Gln
1265                1270                1275                1280
Gln Ser Ser Thr Leu Gly Asn Ser Val Val Arg Cys Asp Lys Leu Asp
                1285                1290                1295    
Gln Ser Glu Ile Lys Ser Leu Leu Met Cys Phe Leu Tyr Ile Leu Lys
            1300                1305                1310        
Ser Met Ser Asp Asp Ala Leu Phe Thr Tyr Trp Asn Lys Ala Ser Thr
        1315                1320                1325            
Ser Glu Leu Met Asp Phe Phe Thr Ile Ser Glu Val Cys Leu His Gln
    1330                1335                1340                
Phe Gln Tyr Met Gly Lys Arg Tyr Ile Ala Arg Thr Gly Met Met His
1345                1350                1355                1360
Ala Arg Leu Gln Gln Leu Gly Ser Leu Asp Asn Ser Leu Thr Phe Asn
                1365                1370                1375    
His Ser Tyr Gly His Ser Asp Ala Asp Val Leu His Gln Ser Leu Leu
            1380                1385                1390        
Glu Ala Asn Ile Ala Thr Glu Val Cys Leu Thr Ala Leu Asp Thr Leu
        1395                1400                1405            
Ser Leu Phe Thr Leu Ala Phe Lys Asn Gln Leu Leu Ala Asp His Gly
    1410                1415                1420                
His Asn Pro Leu Met Lys Lys Val Phe Asp Val Tyr Leu Cys Phe Leu
1425                1430                1435                1440
Gln Lys His Gln Ser Glu Thr Ala Leu Lys Asn Val Phe Thr Ala Leu
                1445                1450                1455    
Arg Ser Leu Ile Tyr Lys Phe Pro Ser Thr Phe Tyr Glu Gly Arg Ala
            1460                1465                1470        
Asp Met Cys Ala Ala Leu Cys Tyr Glu Ile Leu Lys Cys Cys Asn Ser
        1475                1480                1485            
Lys Leu Ser Ser Ile Arg Thr Glu Ala Ser Gln Leu Leu Tyr Phe Leu
    1490                1495                1500                
Met Arg Asn Asn Phe Asp Tyr Thr Gly Lys Lys Ser Phe Val Arg Thr
1505                1510                1515                1520
His Leu Gln Val Ile Ile Ser Val Ser Gln Leu Ile Ala Asp Val Val
                1525                1530                1535    
Gly Ile Gly Gly Thr Arg Phe Gln Gln Ser Leu Ser Ile Ile Asn Asn
            1540                1545                1550        
Cys Ala Asn Ser Asp Arg Leu Ile Lys His Thr Ser Phe Ser Ser Asp
        1555                1560                1565            
Val Lys Asp Leu Thr Lys Arg Ile Arg Thr Val Leu Met Ala Thr Ala
    1570                1575                1580                
Gln Met Lys Glu His Glu Asn Asp Pro Glu Met Leu Val Asp Leu Gln
1585                1590                1595                1600
Tyr Ser Leu Ala Lys Ser Tyr Ala Ser Thr Pro Glu Leu Arg Lys Thr
                1605                1610                1615    
Trp Leu Asp Ser Met Ala Arg Ile His Val Lys Asn Gly Asp Leu Ser
            1620                1625                1630        
Glu Ala Ala Met Cys Tyr Val His Val Thr Ala Leu Val Ala Glu Tyr
        1635                1640                1645            
Leu Thr Arg Lys Glu Ala Val Gln Trp Glu Pro Pro Leu Leu Pro His
    1650                1655                1660                
Ser His Ser Ala Cys Leu Arg Arg Ser Arg Gly Gly Val Phe Arg Gln
1665                1670                1675                1680
Gly Cys Thr Ala Phe Arg Val Ile Thr Pro Asn Ile Asp Glu Glu Ala
                1685                1690                1695    
Ser Met Met Glu Asp Val Gly Met Gln Asp Val His Phe Asn Glu Asp
            1700                1705                1710        
Val Leu Met Glu Leu Leu Glu Gln Cys Ala Asp Gly Leu Trp Lys Ala
        1715                1720                1725            
Glu Arg Tyr Glu Leu Ile Ala Asp Ile Tyr Lys Leu Ile Ile Pro Ile
    1730                1735                1740                
Tyr Glu Lys Arg Arg Asp Phe Glu Arg Leu Ala His Leu Tyr Asp Thr
1745                1750                1755                1760
Leu His Arg Ala Tyr Ser Lys Val Thr Glu Val Met His Ser Gly Arg
                1765                1770                1775    
Arg Leu Leu Gly Thr Tyr Phe Arg Val Ala Phe Phe Gly Gln Gly Phe
            1780                1785                1790        
Phe Glu Asp Glu Asp Gly Lys Glu Tyr Ile Tyr Lys Glu Pro Lys Leu
        1795                1800                1805            
Thr Pro Leu Ser Glu Ile Ser Gln Arg Leu Leu Lys Leu Tyr Ser Asp
    1810                1815                1820                
Lys Phe Gly Ser Glu Asn Val Lys Met Ile Gln Asp Ser Gly Lys Val
1825                1830                1835                1840
Asn Pro Lys Asp Leu Asp Ser Lys Tyr Ala Tyr Ile Gln Val Thr His
                1845                1850                1855    
Val Ile Pro Phe Phe Asp Glu Lys Glu Leu Gln Glu Arg Lys Thr Glu
            1860                1865                1870        
Phe Glu Arg Ser His Asn Ile Arg Arg Phe Met Phe Glu Met Pro Phe
        1875                1880                1885            
Thr Gln Thr Gly Lys Arg Gln Gly Gly Val Glu Glu Gln Cys Lys Arg
    1890                1895                1900                
Arg Thr Ile Leu Thr Ala Ile His Cys Phe Pro Tyr Val Lys Lys Arg
1905                1910                1915                1920
Ile Pro Val Met Tyr Gln His His Thr Asp Leu Asn Pro Ile Glu Val
                1925                1930                1935    
Ala Ile Asp Glu Met Ser Lys Lys Val Ala Glu Leu Arg Gln Leu Cys
            1940                1945                1950        
Ser Ser Ala Glu Val Asp Met Ile Lys Leu Gln Leu Lys Leu Gln Gly
        1955                1960                1965            
Ser Val Ser Val Gln Val Asn Ala Gly Pro Leu Ala Tyr Ala Arg Ala
    1970                1975                1980                
Phe Leu Asp Asp Thr Asn Thr Lys Arg Tyr Pro Asp Asn Lys Val Lys
1985                1990                1995                2000
Leu Leu Lys Glu Val Phe Arg Gln Phe Val Glu Ala Cys Gly Gln Ala
                2005                2010                2015    
Leu Ala Val Asn Glu Arg Leu Ile Lys Glu Asp Gln Leu Glu Tyr Gln
            2020                2025                2030        
Glu Glu Met Lys Ala Asn Tyr Arg Glu Met Ala Lys Glu Leu Ser Glu
        2035                2040                2045            
Ile Met His Glu Gln Ile Cys Pro Leu Glu Glu Lys Thr Ser Val Leu
    2050                2055                2060                
Pro Asn Ser Leu His Ile Phe Asn Ala Ile Ser Gly Thr Pro Thr Ser
2065                2070                2075                2080
Thr Met Val His Gly Met Thr Ser Ser Ser Ser Val Val
                2085                2090            


<210> 7798
<211> 2069
<212> PRT
<213> Homo sapiens

<400> 7798
Met Ser Gln Pro Pro Leu Leu Pro Ala Ser Ala Glu Thr Arg Lys Phe
 1               5                  10                  15      
Thr Arg Ala Leu Ser Lys Pro Gly Thr Ala Ala Glu Leu Arg Gln Ser
            20                  25                  30          
Val Ser Glu Val Val Arg Gly Ser Val Leu Leu Ala Lys Pro Lys Leu
        35                  40                  45              
Ile Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln
    50                  55                  60                  
Ile Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp
65                  70                  75                  80  
Phe Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr
                85                  90                  95      
Val Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu
            100                 105                 110         
Cys Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr
        115                 120                 125             
Glu Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys
    130                 135                 140                 
Leu Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp
145                 150                 155                 160 
Lys Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr
                165                 170                 175     
Lys His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val
            180                 185                 190         
Thr Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly
        195                 200                 205             
Asp Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys
    210                 215                 220                 
Glu Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln
225                 230                 235                 240 
Asn Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys
                245                 250                 255     
Ser Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp
            260                 265                 270         
Ile Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met
        275                 280                 285             
Gln Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys
    290                 295                 300                 
Leu Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala
305                 310                 315                 320 
Lys Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val
                325                 330                 335     
Lys Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser
            340                 345                 350         
Ala Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile
        355                 360                 365             
Leu Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala
    370                 375                 380                 
Glu Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr
385                 390                 395                 400 
Leu Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe
                405                 410                 415     
His Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr
            420                 425                 430         
Ser Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys
        435                 440                 445             
Gly Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe
    450                 455                 460                 
Ser Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu
465                 470                 475                 480 
Lys Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys
                485                 490                 495     
Ser Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys
            500                 505                 510         
Gln Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala
        515                 520                 525             
Ala Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala
    530                 535                 540                 
Arg Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp
545                 550                 555                 560 
Asp Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala
                565                 570                 575     
Lys Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val
            580                 585                 590         
Ser Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys
        595                 600                 605             
Gln Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu
    610                 615                 620                 
Phe Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr
625                 630                 635                 640 
Asn His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys
                645                 650                 655     
Ser Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp
            660                 665                 670         
Ser Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro
        675                 680                 685             
Gly Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His
    690                 695                 700                 
His Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr
705                 710                 715                 720 
Gln Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser
                725                 730                 735     
Cys Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu
            740                 745                 750         
Thr Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val
        755                 760                 765             
Val Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly
    770                 775                 780                 
Tyr Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu
785                 790                 795                 800 
Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His
                805                 810                 815     
Leu Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe
            820                 825                 830         
Gln Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu
        835                 840                 845             
Leu Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met
    850                 855                 860                 
Ile Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr
865                 870                 875                 880 
Arg Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile
                885                 890                 895     
His Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg
            900                 905                 910         
Ser Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu
        915                 920                 925             
Tyr Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu
    930                 935                 940                 
Lys Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser
945                 950                 955                 960 
Trp Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile
                965                 970                 975     
Glu Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser
            980                 985                 990         
Tyr His His Ala Val Glu Thr Val Val Asn Met Leu Met Pro His Ile
        995                 1000                1005            
Thr Gln Lys Phe Arg Asp Asn Pro Glu Ala Ser Lys Asn Ala Asn His
    1010                1015                1020                
Ser Leu Ala Val Phe Ile Lys Arg Cys Phe Thr Phe Met Asp Arg Gly
1025                1030                1035                1040
Phe Val Phe Lys Gln Ile Asn Asn Tyr Ile Ser Cys Phe Ala Pro Gly
                1045                1050                1055    
Asp Pro Lys Thr Leu Phe Glu Tyr Lys Phe Glu Phe Leu Arg Val Val
            1060                1065                1070        
Cys Asn His Glu His Tyr Ile Pro Leu Asn Leu Pro Met Pro Phe Gly
        1075                1080                1085            
Lys Gly Arg Ile Gln Arg Tyr Gln Asp Leu Gln Leu Asp Tyr Ser Leu
    1090                1095                1100                
Thr Asp Glu Phe Cys Arg Asn His Phe Leu Val Gly Leu Leu Leu Arg
1105                1110                1115                1120
Glu Val Gly Thr Ala Leu Gln Glu Phe Arg Glu Val Arg Leu Ile Ala
                1125                1130                1135    
Ile Ser Val Leu Lys Asn Leu Leu Ile Lys His Ser Phe Asp Asp Arg
            1140                1145                1150        
Tyr Ala Ser Arg Ser His Gln Ala Arg Ile Ala Thr Leu Tyr Leu Pro
        1155                1160                1165            
Leu Phe Gly Leu Leu Ile Glu Asn Val Gln Arg Ile Asn Val Arg Asp
    1170                1175                1180                
Val Ser Pro Phe Pro Val Asn Ala Gly Met Thr Val Lys Asp Glu Ser
1185                1190                1195                1200
Leu Ala Leu Pro Ala Val Asn Pro Leu Val Thr Pro Gln Lys Gly Ser
                1205                1210                1215    
Thr Leu Asp Asn Ser Leu His Lys Asp Leu Leu Gly Ala Ile Ser Gly
            1220                1225                1230        
Ile Ala Ser Pro Tyr Thr Thr Ser Thr Pro Asn Ile Asn Ser Val Arg
        1235                1240                1245            
Asn Ala Asp Ser Arg Gly Ser Leu Ile Ser Thr Asp Ser Gly Asn Ser
    1250                1255                1260                
Leu Pro Glu Arg Asn Ser Glu Lys Ser Asn Ser Leu Asp Lys His Gln
1265                1270                1275                1280
Gln Ser Ser Thr Leu Gly Asn Ser Val Val Arg Cys Asp Lys Leu Asp
                1285                1290                1295    
Gln Ser Glu Ile Lys Ser Leu Leu Met Cys Phe Leu Tyr Ile Leu Lys
            1300                1305                1310        
Ser Met Ser Asp Asp Ala Leu Phe Thr Tyr Trp Asn Lys Ala Ser Thr
        1315                1320                1325            
Ser Glu Leu Met Asp Phe Phe Thr Ile Ser Glu Val Cys Leu His Gln
    1330                1335                1340                
Phe Gln Tyr Met Gly Lys Arg Tyr Ile Ala Arg Thr Gly Met Met His
1345                1350                1355                1360
Ala Arg Leu Gln Gln Leu Gly Ser Leu Asp Asn Ser Leu Thr Phe Asn
                1365                1370                1375    
His Ser Tyr Gly His Ser Asp Ala Asp Val Leu His Gln Ser Leu Leu
            1380                1385                1390        
Glu Ala Asn Ile Ala Thr Glu Val Cys Leu Thr Ala Leu Asp Thr Leu
        1395                1400                1405            
Ser Leu Phe Thr Leu Ala Phe Lys Asn Gln Leu Leu Ala Asp His Gly
    1410                1415                1420                
His Asn Pro Leu Met Lys Lys Val Phe Asp Val Tyr Leu Cys Phe Leu
1425                1430                1435                1440
Gln Lys His Gln Ser Glu Thr Ala Leu Lys Asn Val Phe Thr Ala Leu
                1445                1450                1455    
Arg Ser Leu Ile Tyr Lys Phe Pro Ser Thr Phe Tyr Glu Gly Arg Ala
            1460                1465                1470        
Asp Met Cys Ala Ala Leu Cys Tyr Glu Ile Leu Lys Cys Cys Asn Ser
        1475                1480                1485            
Lys Leu Ser Ser Ile Arg Thr Glu Ala Ser Gln Leu Leu Tyr Phe Leu
    1490                1495                1500                
Met Arg Asn Asn Phe Asp Tyr Thr Gly Lys Lys Ser Phe Val Arg Thr
1505                1510                1515                1520
His Leu Gln Val Ile Ile Ser Val Ser Gln Leu Ile Ala Asp Val Val
                1525                1530                1535    
Gly Ile Gly Gly Thr Arg Phe Gln Gln Ser Leu Ser Ile Ile Asn Asn
            1540                1545                1550        
Cys Ala Asn Ser Asp Arg Leu Ile Lys His Thr Ser Phe Ser Ser Asp
        1555                1560                1565            
Val Lys Asp Leu Thr Lys Arg Ile Arg Thr Val Leu Met Ala Thr Ala
    1570                1575                1580                
Gln Met Lys Glu His Glu Asn Asp Pro Glu Met Leu Val Asp Leu Gln
1585                1590                1595                1600
Tyr Ser Leu Ala Lys Ser Tyr Ala Ser Thr Pro Glu Leu Arg Lys Thr
                1605                1610                1615    
Trp Leu Asp Ser Met Ala Arg Ile His Val Lys Asn Gly Asp Leu Ser
            1620                1625                1630        
Glu Ala Ala Met Cys Tyr Val His Val Thr Ala Leu Val Ala Glu Tyr
        1635                1640                1645            
Leu Thr Arg Lys Glu Ala Val Gln Trp Glu Pro Pro Leu Leu Pro His
    1650                1655                1660                
Ser His Ser Ala Cys Leu Arg Arg Ser Arg Gly Gly Val Phe Arg Gln
1665                1670                1675                1680
Gly Cys Thr Ala Phe Arg Val Ile Thr Pro Asn Ile Asp Glu Glu Ala
                1685                1690                1695    
Ser Met Met Glu Asp Val Gly Met Gln Asp Val His Phe Asn Glu Asp
            1700                1705                1710        
Val Leu Met Glu Leu Leu Glu Gln Cys Ala Asp Gly Leu Trp Lys Ala
        1715                1720                1725            
Glu Arg Tyr Glu Leu Ile Ala Asp Ile Tyr Lys Leu Ile Ile Pro Ile
    1730                1735                1740                
Tyr Glu Lys Arg Arg Asp Phe Glu Arg Leu Ala His Leu Tyr Asp Thr
1745                1750                1755                1760
Leu His Arg Ala Tyr Ser Lys Val Thr Glu Val Met His Ser Gly Arg
                1765                1770                1775    
Arg Leu Leu Gly Thr Tyr Phe Arg Val Ala Phe Phe Gly Gln Ala Ala
            1780                1785                1790        
Gln Tyr Gln Phe Thr Asp Ser Glu Thr Asp Val Glu Gly Phe Phe Glu
        1795                1800                1805            
Asp Glu Asp Gly Lys Glu Tyr Ile Tyr Lys Glu Pro Lys Leu Thr Pro
    1810                1815                1820                
Leu Ser Glu Ile Ser Gln Arg Leu Leu Lys Leu Tyr Ser Asp Lys Phe
1825                1830                1835                1840
Gly Ser Glu Asn Val Lys Met Ile Gln Asp Ser Gly Lys Val Asn Pro
                1845                1850                1855    
Lys Asp Leu Asp Ser Lys Tyr Ala Tyr Ile Gln Val Thr His Val Ile
            1860                1865                1870        
Pro Phe Phe Asp Glu Lys Glu Leu Gln Glu Arg Lys Thr Glu Phe Glu
        1875                1880                1885            
Arg Ser His Asn Ile Arg Arg Phe Met Phe Glu Met Pro Phe Thr Gln
    1890                1895                1900                
Thr Gly Lys Arg Gln Gly Gly Val Glu Glu Gln Cys Lys Arg Arg Thr
1905                1910                1915                1920
Ile Leu Thr Ala Ile His Cys Phe Pro Tyr Val Lys Lys Arg Ile Pro
                1925                1930                1935    
Val Met Tyr Gln His His Thr Asp Leu Asn Pro Ile Glu Val Ala Ile
            1940                1945                1950        
Asp Glu Met Ser Lys Lys Val Ala Glu Leu Arg Gln Leu Cys Ser Ser
        1955                1960                1965            
Ala Glu Val Asp Met Ile Lys Leu Gln Leu Lys Leu Gln Gly Ser Val
    1970                1975                1980                
Ser Val Gln Val Asn Ala Gly Pro Leu Ala Tyr Ala Arg Ala Phe Leu
1985                1990                1995                2000
Asp Asp Thr Asn Thr Lys Arg Tyr Pro Asp Asn Lys Val Lys Leu Leu
                2005                2010                2015    
Lys Glu Val Phe Arg Gln Phe Val Glu Ala Cys Gly Gln Ala Leu Ala
            2020                2025                2030        
Val Asn Glu Arg Leu Ile Lys Glu Asp Gln Leu Glu Tyr Gln Glu Glu
        2035                2040                2045            
Met Lys Ala Asn Tyr Arg Glu Met Ala Lys Glu Leu Ser Glu Ile Met
    2050                2055                2060                
His Glu Gln Leu Gly
2065                


<210> 7799
<211> 2061
<212> PRT
<213> Homo sapiens

<400> 7799
Met Ser Gln Pro Pro Leu Leu Pro Ala Ser Ala Glu Thr Arg Lys Phe
 1               5                  10                  15      
Thr Arg Ala Leu Ser Lys Pro Gly Thr Ala Ala Glu Leu Arg Gln Ser
            20                  25                  30          
Val Ser Glu Val Val Arg Gly Ser Val Leu Leu Ala Lys Pro Lys Leu
        35                  40                  45              
Ile Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln
    50                  55                  60                  
Ile Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp
65                  70                  75                  80  
Phe Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr
                85                  90                  95      
Val Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu
            100                 105                 110         
Cys Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr
        115                 120                 125             
Glu Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys
    130                 135                 140                 
Leu Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp
145                 150                 155                 160 
Lys Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr
                165                 170                 175     
Lys His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val
            180                 185                 190         
Thr Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly
        195                 200                 205             
Asp Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys
    210                 215                 220                 
Glu Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln
225                 230                 235                 240 
Asn Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys
                245                 250                 255     
Ser Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp
            260                 265                 270         
Ile Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met
        275                 280                 285             
Gln Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys
    290                 295                 300                 
Leu Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala
305                 310                 315                 320 
Lys Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val
                325                 330                 335     
Lys Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser
            340                 345                 350         
Ala Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile
        355                 360                 365             
Leu Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala
    370                 375                 380                 
Glu Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr
385                 390                 395                 400 
Leu Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe
                405                 410                 415     
His Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr
            420                 425                 430         
Ser Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys
        435                 440                 445             
Gly Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe
    450                 455                 460                 
Ser Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu
465                 470                 475                 480 
Lys Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys
                485                 490                 495     
Ser Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys
            500                 505                 510         
Gln Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala
        515                 520                 525             
Ala Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala
    530                 535                 540                 
Arg Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp
545                 550                 555                 560 
Asp Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala
                565                 570                 575     
Lys Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val
            580                 585                 590         
Ser Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys
        595                 600                 605             
Gln Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu
    610                 615                 620                 
Phe Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr
625                 630                 635                 640 
Asn His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys
                645                 650                 655     
Ser Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp
            660                 665                 670         
Ser Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro
        675                 680                 685             
Gly Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His
    690                 695                 700                 
His Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr
705                 710                 715                 720 
Gln Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser
                725                 730                 735     
Cys Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu
            740                 745                 750         
Thr Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val
        755                 760                 765             
Val Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly
    770                 775                 780                 
Tyr Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu
785                 790                 795                 800 
Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His
                805                 810                 815     
Leu Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe
            820                 825                 830         
Gln Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu
        835                 840                 845             
Leu Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met
    850                 855                 860                 
Ile Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr
865                 870                 875                 880 
Arg Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile
                885                 890                 895     
His Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg
            900                 905                 910         
Ser Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu
        915                 920                 925             
Tyr Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu
    930                 935                 940                 
Lys Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser
945                 950                 955                 960 
Trp Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile
                965                 970                 975     
Glu Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser
            980                 985                 990         
Tyr His His Ala Val Glu Thr Val Val Asn Met Leu Met Pro His Ile
        995                 1000                1005            
Thr Gln Lys Phe Arg Asp Asn Pro Glu Ala Ser Lys Asn Ala Asn His
    1010                1015                1020                
Ser Leu Ala Val Phe Ile Lys Arg Cys Phe Thr Phe Met Asp Arg Gly
1025                1030                1035                1040
Phe Val Phe Lys Gln Ile Asn Asn Tyr Ile Ser Cys Phe Ala Pro Gly
                1045                1050                1055    
Asp Pro Lys Thr Leu Phe Glu Tyr Lys Phe Glu Phe Leu Arg Val Val
            1060                1065                1070        
Cys Asn His Glu His Tyr Ile Pro Leu Asn Leu Pro Met Pro Phe Gly
        1075                1080                1085            
Lys Gly Arg Ile Gln Arg Tyr Gln Asp Leu Gln Leu Asp Tyr Ser Leu
    1090                1095                1100                
Thr Asp Glu Phe Cys Arg Asn His Phe Leu Val Gly Leu Leu Leu Arg
1105                1110                1115                1120
Glu Val Gly Thr Ala Leu Gln Glu Phe Arg Glu Val Arg Leu Ile Ala
                1125                1130                1135    
Ile Ser Val Leu Lys Asn Leu Leu Ile Lys His Ser Phe Asp Asp Arg
            1140                1145                1150        
Tyr Ala Ser Arg Ser His Gln Ala Arg Ile Ala Thr Leu Tyr Leu Pro
        1155                1160                1165            
Leu Phe Gly Leu Leu Ile Glu Asn Val Gln Arg Ile Asn Val Arg Asp
    1170                1175                1180                
Val Ser Pro Phe Pro Val Asn Ala Gly Met Thr Val Lys Asp Glu Ser
1185                1190                1195                1200
Leu Ala Leu Pro Ala Val Asn Pro Leu Val Thr Pro Gln Lys Gly Ser
                1205                1210                1215    
Thr Leu Asp Asn Ser Leu His Lys Asp Leu Leu Gly Ala Ile Ser Gly
            1220                1225                1230        
Ile Ala Ser Pro Tyr Thr Thr Ser Thr Pro Asn Ile Asn Ser Val Arg
        1235                1240                1245            
Asn Ala Asp Ser Arg Gly Ser Leu Ile Ser Thr Asp Ser Gly Asn Ser
    1250                1255                1260                
Leu Pro Glu Arg Asn Ser Glu Lys Ser Asn Ser Leu Asp Lys His Gln
1265                1270                1275                1280
Gln Ser Ser Thr Leu Gly Asn Ser Val Val Arg Cys Asp Lys Leu Asp
                1285                1290                1295    
Gln Ser Glu Ile Lys Ser Leu Leu Met Cys Phe Leu Tyr Ile Leu Lys
            1300                1305                1310        
Ser Met Ser Asp Asp Ala Leu Phe Thr Tyr Trp Asn Lys Ala Ser Thr
        1315                1320                1325            
Ser Glu Leu Met Asp Phe Phe Thr Ile Ser Glu Val Cys Leu His Gln
    1330                1335                1340                
Phe Gln Tyr Met Gly Lys Arg Tyr Ile Ala Ser Val Arg Lys Ile Ser
1345                1350                1355                1360
Ser Val Leu Gly Ile Ser Val Asp Asn Gly Tyr Gly His Ser Asp Ala
                1365                1370                1375    
Asp Val Leu His Gln Ser Leu Leu Glu Ala Asn Ile Ala Thr Glu Val
            1380                1385                1390        
Cys Leu Thr Ala Leu Asp Thr Leu Ser Leu Phe Thr Leu Ala Phe Lys
        1395                1400                1405            
Asn Gln Leu Leu Ala Asp His Gly His Asn Pro Leu Met Lys Lys Val
    1410                1415                1420                
Phe Asp Val Tyr Leu Cys Phe Leu Gln Lys His Gln Ser Glu Thr Ala
1425                1430                1435                1440
Leu Lys Asn Val Phe Thr Ala Leu Arg Ser Leu Ile Tyr Lys Phe Pro
                1445                1450                1455    
Ser Thr Phe Tyr Glu Gly Arg Ala Asp Met Cys Ala Ala Leu Cys Tyr
            1460                1465                1470        
Glu Ile Leu Lys Cys Cys Asn Ser Lys Leu Ser Ser Ile Arg Thr Glu
        1475                1480                1485            
Ala Ser Gln Leu Leu Tyr Phe Leu Met Arg Asn Asn Phe Asp Tyr Thr
    1490                1495                1500                
Gly Lys Lys Ser Phe Val Arg Thr His Leu Gln Val Ile Ile Ser Val
1505                1510                1515                1520
Ser Gln Leu Ile Ala Asp Val Val Gly Ile Gly Gly Thr Arg Phe Gln
                1525                1530                1535    
Gln Ser Leu Ser Ile Ile Asn Asn Cys Ala Asn Ser Asp Arg Leu Ile
            1540                1545                1550        
Lys His Thr Ser Phe Ser Ser Asp Val Lys Asp Leu Thr Lys Arg Ile
        1555                1560                1565            
Arg Thr Val Leu Met Ala Thr Ala Gln Met Lys Glu His Glu Asn Asp
    1570                1575                1580                
Pro Glu Met Leu Val Asp Leu Gln Tyr Ser Leu Ala Lys Ser Tyr Ala
1585                1590                1595                1600
Ser Thr Pro Glu Leu Arg Lys Thr Trp Leu Asp Ser Met Ala Arg Ile
                1605                1610                1615    
His Val Lys Asn Gly Asp Leu Ser Glu Ala Ala Met Cys Tyr Val His
            1620                1625                1630        
Val Thr Ala Leu Val Ala Glu Tyr Leu Thr Arg Lys Glu Ala Val Gln
        1635                1640                1645            
Trp Glu Pro Pro Leu Leu Pro His Ser His Ser Ala Cys Leu Arg Arg
    1650                1655                1660                
Ser Arg Gly Gly Val Phe Arg Gln Gly Cys Thr Ala Phe Arg Val Ile
1665                1670                1675                1680
Thr Pro Asn Ile Asp Glu Glu Ala Ser Met Met Glu Asp Val Gly Met
                1685                1690                1695    
Gln Asp Val His Phe Asn Glu Asp Val Leu Met Glu Leu Leu Glu Gln
            1700                1705                1710        
Cys Ala Asp Gly Leu Trp Lys Ala Glu Arg Tyr Glu Leu Ile Ala Asp
        1715                1720                1725            
Ile Tyr Lys Leu Ile Ile Pro Ile Tyr Glu Lys Arg Arg Asp Phe Glu
    1730                1735                1740                
Arg Leu Ala His Leu Tyr Asp Thr Leu His Arg Ala Tyr Ser Lys Val
1745                1750                1755                1760
Thr Glu Val Met His Ser Gly Arg Arg Leu Leu Gly Thr Tyr Phe Arg
                1765                1770                1775    
Val Ala Phe Phe Gly Gln Ala Ala Gln Tyr Gln Phe Thr Asp Ser Glu
            1780                1785                1790        
Thr Asp Val Glu Gly Phe Phe Glu Asp Glu Asp Gly Lys Glu Tyr Ile
        1795                1800                1805            
Tyr Lys Glu Pro Lys Leu Thr Pro Leu Ser Glu Ile Ser Gln Arg Leu
    1810                1815                1820                
Leu Lys Leu Tyr Ser Asp Lys Phe Gly Ser Glu Asn Val Lys Met Ile
1825                1830                1835                1840
Gln Asp Ser Gly Lys Val Asn Pro Lys Asp Leu Asp Ser Lys Tyr Ala
                1845                1850                1855    
Tyr Ile Gln Val Thr His Val Ile Pro Phe Phe Asp Glu Lys Glu Leu
            1860                1865                1870        
Gln Glu Arg Lys Thr Glu Phe Glu Arg Ser His Asn Ile Arg Arg Phe
        1875                1880                1885            
Met Phe Glu Met Pro Phe Thr Gln Thr Gly Lys Arg Gln Gly Gly Val
    1890                1895                1900                
Glu Glu Gln Cys Lys Arg Arg Thr Ile Leu Thr Ala Ile His Cys Phe
1905                1910                1915                1920
Pro Tyr Val Lys Lys Arg Ile Pro Val Met Tyr Gln His His Thr Asp
                1925                1930                1935    
Leu Asn Pro Ile Glu Val Ala Ile Asp Glu Met Ser Lys Lys Val Ala
            1940                1945                1950        
Glu Leu Arg Gln Leu Cys Ser Ser Ala Glu Val Asp Met Ile Lys Leu
        1955                1960                1965            
Gln Leu Lys Leu Gln Gly Ser Val Ser Val Gln Val Asn Ala Gly Pro
    1970                1975                1980                
Leu Ala Tyr Ala Arg Ala Phe Leu Asp Asp Thr Asn Thr Lys Arg Tyr
1985                1990                1995                2000
Pro Asp Asn Lys Val Lys Leu Leu Lys Glu Val Phe Arg Gln Phe Val
                2005                2010                2015    
Glu Ala Cys Gly Gln Ala Leu Ala Val Asn Glu Arg Leu Ile Lys Glu
            2020                2025                2030        
Asp Gln Leu Glu Tyr Gln Glu Glu Met Lys Ala Asn Tyr Arg Glu Met
        2035                2040                2045            
Ala Lys Glu Leu Ser Glu Ile Met His Glu Gln Leu Gly
    2050                2055                2060    


<210> 7800
<211> 655
<212> PRT
<213> Homo sapiens

<400> 7800
Met Ala Glu Ala Pro Gln Val Val Glu Ile Asp Pro Asp Phe Glu Pro
 1               5                  10                  15      
Leu Pro Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe
            20                  25                  30          
Ser Gln Ser Asn Ser Ala Thr Ser Ser Pro Ala Pro Ser Gly Ser Ala
        35                  40                  45              
Ala Ala Asn Pro Asp Ala Ala Ala Gly Leu Pro Ser Ala Ser Ala Ala
    50                  55                  60                  
Ala Val Ser Ala Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Pro Gln Ala Pro Gly Ser Val Ala Ala Ala Val Ala Ala
                85                  90                  95      
Ala Ala Ala Ala Ala Ala Thr Gly Gly Leu Cys Gly Asp Phe Gln Gly
            100                 105                 110         
Pro Glu Ala Gly Cys Leu His Pro Ala Pro Pro Gln Pro Pro Pro Pro
        115                 120                 125             
Gly Pro Val Ser Gln His Pro Pro Val Pro Pro Ala Ala Ala Gly Pro
    130                 135                 140                 
Leu Ala Gly Gln Pro Arg Lys Ser Ser Ser Ser Arg Arg Asn Ala Trp
145                 150                 155                 160 
Gly Asn Leu Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser
                165                 170                 175     
Ala Glu Lys Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys
            180                 185                 190         
Ser Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly
        195                 200                 205             
Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile
    210                 215                 220                 
Arg Val Gln Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn
225                 230                 235                 240 
Pro Glu Gly Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser
                245                 250                 255     
Met Asp Asn Asn Ser Lys Phe Ala Lys Ser Arg Ser Arg Ala Ala Lys
            260                 265                 270         
Lys Lys Ala Ser Leu Gln Ser Gly Gln Glu Gly Ala Gly Asp Ser Pro
        275                 280                 285             
Gly Ser Gln Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn
    290                 295                 300                 
Asp Asp Phe Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn
305                 310                 315                 320 
Ala Ser Thr Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp
                325                 330                 335     
Asp Leu Gly Glu Gly Asp Val His Ser Met Val Tyr Pro Pro Ser Ala
            340                 345                 350         
Ala Lys Met Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro
        355                 360                 365             
Glu Asn Met Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro
    370                 375                 380                 
Thr Ser Leu Thr Val Ser Thr Gln Ser Ser Pro Gly Thr Met Met Gln
385                 390                 395                 400 
Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser
                405                 410                 415     
Pro Ser Pro Asn Tyr Gln Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser
            420                 425                 430         
Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln Asp Asn Lys Ser Ser
        435                 440                 445             
Tyr Gly Gly Met Ser Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu
    450                 455                 460                 
Leu Leu Thr Ser Asp Ser Pro Pro His Asn Asp Ile Met Thr Pro Val
465                 470                 475                 480 
Asp Pro Gly Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val
                485                 490                 495     
Met Met Gly Pro Asn Ser Val Met Ser Thr Tyr Gly Ser Gln Ala Ser
            500                 505                 510         
His Asn Lys Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala
        515                 520                 525             
Gln Gln Thr Ser Ala Val Asn Gly Arg Pro Leu Pro His Thr Val Ser
    530                 535                 540                 
Thr Met Pro His Thr Ser Gly Met Asn Arg Leu Thr Gln Val Lys Thr
545                 550                 555                 560 
Pro Val Gln Val Pro Leu Pro His Pro Met Gln Met Ser Ala Leu Gly
                565                 570                 575     
Gly Tyr Ser Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Leu
            580                 585                 590         
Leu His Gln Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu
        595                 600                 605             
Arg Leu Asp Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp
    610                 615                 620                 
Gly Asp Thr Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser
625                 630                 635                 640 
Phe Pro His Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly
                645                 650                 655 


<210> 7801
<211> 414
<212> PRT
<213> Homo sapiens

<400> 7801
Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile
 1               5                  10                  15      
Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr
            20                  25                  30          
Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser
        35                  40                  45              
Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro
    50                  55                  60                  
Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp
65                  70                  75                  80  
Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val
                85                  90                  95      
Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro
            100                 105                 110         
Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly
        115                 120                 125             
Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser
    130                 135                 140                 
Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys
145                 150                 155                 160 
Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys
                165                 170                 175     
Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys
            180                 185                 190         
Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg
        195                 200                 205             
Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys
    210                 215                 220                 
Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala
225                 230                 235                 240 
Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His
                245                 250                 255     
Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg
            260                 265                 270         
Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly
        275                 280                 285             
Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly
    290                 295                 300                 
Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro
305                 310                 315                 320 
Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met
                325                 330                 335     
Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn
            340                 345                 350         
Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly
        355                 360                 365             
Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly
    370                 375                 380                 
Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly
385                 390                 395                 400 
Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met
                405                 410                 


<210> 7802
<211> 1078
<212> PRT
<213> Homo sapiens

<400> 7802
Pro Pro Gly Pro Glu Arg Ser Arg Leu Gly Leu Gly Val Ser Leu His
 1               5                  10                  15      
Gln Arg Ser Cys Pro Lys Cys Ile Ala Val Phe Thr Arg Val Ser Glu
            20                  25                  30          
Pro Arg Ile Gln Phe Pro Ala Ser Arg Ile Leu Pro Ser Ser Asn Thr
        35                  40                  45              
Ser Lys Asp Phe Asp Pro Val Ser Gly Gln Ser Asn Tyr Gly Gly Ser
    50                  55                  60                  
Gln Gly Ser Gly Gln Thr Leu Asn Arg Pro Pro Val Ala Ser Asn Pro
65                  70                  75                  80  
Val Thr Pro Ser Leu His Ser Gly Pro Ala Pro Arg Met Pro Leu Pro
                85                  90                  95      
Ala Ser Gln Asn Pro Ala Thr Thr Pro Met Pro Ser Ser Ser Phe Leu
            100                 105                 110         
Pro Glu Ala Asn Leu Pro Pro Pro Leu Asn Trp Gln Tyr Asn Tyr Pro
        115                 120                 125             
Ser Thr Ala Ser Gln Thr Asn His Cys Pro Arg Ala Ser Ser Gln Pro
    130                 135                 140                 
Thr Val Ser Gly Asn Thr Ser Leu Thr Thr Asn His Gln Tyr Val Ser
145                 150                 155                 160 
Ser Gly Tyr Pro Ser Leu Gln Asn Ser Phe Ile Lys Ser Gly Pro Ser
                165                 170                 175     
Val Pro Pro Leu Val Asn Pro Pro Leu Pro Thr Thr Phe Gln Pro Gly
            180                 185                 190         
Ala Pro His Gly Pro Pro Pro Ala Gly Gly Pro Pro Pro Val Arg Ala
        195                 200                 205             
Leu Thr Pro Leu Thr Ser Ser Tyr Arg Asp Val Pro Gln Pro Leu Phe
    210                 215                 220                 
Asn Ser Ala Val Asn Gln Glu Gly Ile Thr Ser Asn Thr Asn Asn Gly
225                 230                 235                 240 
Ser Met Val Val His Ser Ser Tyr Asp Glu Ile Glu Gly Gly Gly Leu
                245                 250                 255     
Leu Ala Thr Pro Gln Leu Thr Asn Lys Asn Pro Lys Met Ser Arg Ser
            260                 265                 270         
Val Gly Tyr Ser Tyr Pro Ser Leu Pro Pro Gly Tyr Gln Asn Thr Thr
        275                 280                 285             
Pro Pro Gly Ala Thr Gly Val Pro Pro Ser Ser Leu Asn Tyr Pro Ser
    290                 295                 300                 
Gly Pro Gln Ala Phe Thr Gln Thr Pro Leu Gly Ala Asn His Leu Thr
305                 310                 315                 320 
Thr Ser Met Ser Gly Leu Ser Leu Gln Pro Glu Gly Leu Arg Val Val
                325                 330                 335     
Asn Leu Leu Gln Glu Arg Asn Met Leu Pro Ser Thr Pro Leu Lys Pro
            340                 345                 350         
Pro Val Pro Asn Leu His Glu Asp Ile Gln Lys Leu Asn Cys Asn Pro
        355                 360                 365             
Glu Leu Phe Arg Cys Thr Leu Thr Ser Ile Pro Gln Thr Gln Ala Leu
    370                 375                 380                 
Leu Asn Lys Ala Lys Leu Pro Leu Gly Leu Leu Leu His Pro Phe Lys
385                 390                 395                 400 
Asp Leu Val Gln Leu Pro Val Val Thr Ser Ser Thr Ile Val Arg Cys
                405                 410                 415     
Arg Ser Cys Arg Thr Tyr Ile Asn Pro Phe Val Ser Phe Leu Asp Gln
            420                 425                 430         
Arg Arg Trp Lys Cys Asn Leu Cys Tyr Arg Val Asn Asp Val Pro Glu
        435                 440                 445             
Glu Phe Leu Tyr Asn Pro Leu Thr Arg Val Tyr Gly Glu Pro His Arg
    450                 455                 460                 
Arg Pro Glu Val Gln Asn Ala Thr Ile Glu Phe Met Ala Pro Ser Glu
465                 470                 475                 480 
Tyr Met Leu Arg Pro Pro Gln Pro Pro Val Tyr Leu Phe Val Phe Asp
                485                 490                 495     
Val Ser His Asn Ala Val Glu Thr Gly Tyr Leu Asn Ser Val Cys Gln
            500                 505                 510         
Ser Leu Leu Asp Asn Leu Asp Leu Leu Pro Gly Asn Thr Arg Thr Lys
        515                 520                 525             
Ile Gly Phe Ile Thr Phe Asp Ser Thr Ile His Phe Tyr Gly Leu Gln
    530                 535                 540                 
Glu Ser Leu Ser Gln Pro Gln Met Leu Ile Val Ser Asp Ile Glu Asp
545                 550                 555                 560 
Val Phe Ile Pro Met Pro Glu Asn Leu Leu Val Asn Leu Asn Glu Ser
                565                 570                 575     
Lys Glu Leu Val Gln Asp Leu Leu Lys Thr Leu Pro Gln Met Phe Thr
            580                 585                 590         
Lys Thr Leu Glu Thr Gln Ser Ala Leu Gly Pro Ala Leu Gln Ala Ala
        595                 600                 605             
Phe Lys Leu Met Ser Pro Thr Gly Gly Arg Met Ser Val Phe Gln Thr
    610                 615                 620                 
Gln Leu Pro Thr Leu Gly Val Gly Ala Leu Lys Pro Arg Glu Glu Pro
625                 630                 635                 640 
Asn His Arg Ser Ser Ala Lys Asp Ile His Met Thr Pro Ser Thr Asp
                645                 650                 655     
Phe Tyr Lys Lys Leu Ala Leu Asp Cys Ser Gly Gln Gln Val Ala Val
            660                 665                 670         
Asp Leu Phe Leu Leu Ser Gly Gln Tyr Ser Asp Leu Ala Ser Leu Gly
        675                 680                 685             
Cys Ile Ser Arg Tyr Ser Ala Gly Ser Val Tyr Tyr Tyr Pro Ser Tyr
    690                 695                 700                 
His His Gln His Asn Pro Val Gln Val Gln Lys Leu Gln Lys Glu Leu
705                 710                 715                 720 
Gln Arg Tyr Leu Thr Arg Lys Ile Gly Phe Glu Ala Val Met Arg Ile
                725                 730                 735     
Arg Cys Thr Lys Gly Leu Ser Ile His Thr Phe His Gly Asn Phe Phe
            740                 745                 750         
Val Arg Ser Thr Asp Leu Leu Ser Leu Pro Asn Val Asn Pro Asp Ala
        755                 760                 765             
Gly Tyr Ala Val Gln Met Ser Val Glu Glu Ser Leu Thr Asp Thr Gln
    770                 775                 780                 
Leu Val Ser Phe Gln Ser Ala Leu Leu Tyr Thr Ser Ser Lys Gly Glu
785                 790                 795                 800 
Arg Arg Ile Arg Val His Thr Leu Cys Leu Pro Val Val Ser Thr Leu
                805                 810                 815     
Asn Asp Val Phe Leu Gly Ala Asp Val Gln Ala Ile Ser Gly Leu Leu
            820                 825                 830         
Ala Asn Met Ala Val Asp Arg Ser Met Thr Ala Ser Leu Ser Asp Ala
        835                 840                 845             
Arg Asp Ala Leu Val Asn Ala Val Ile Asp Ser Leu Ser Ala Tyr Arg
    850                 855                 860                 
Ser Ser Val Leu Ser Asn Gln Gln Pro Gly Leu Met Val Pro Phe Ser
865                 870                 875                 880 
Leu Arg Leu Phe Pro Leu Phe Val Leu Ala Leu Leu Lys Gln Lys Ser
                885                 890                 895     
Phe Gln Thr Gly Thr Asn Ala Arg Leu Asp Glu Arg Ile Phe Ala Met
            900                 905                 910         
Cys Gln Val Lys Asn Gln Pro Leu Val Tyr Leu Met Leu Thr Thr His
        915                 920                 925             
Pro Ser Leu Tyr Arg Val Asp Asn Leu Ser Asp Glu Gly Ala Leu Asn
    930                 935                 940                 
Ile Ser Asp Arg Thr Ile Pro Gln Pro Pro Ile Leu Gln Leu Ser Val
945                 950                 955                 960 
Glu Lys Leu Ser Arg Asp Gly Ala Phe Leu Met Asp Ala Gly Ser Val
                965                 970                 975     
Leu Met Leu Trp Val Gly Lys Asn Cys Thr Gln Asn Phe Leu Ser Gln
            980                 985                 990         
Val Leu Gly Val Gln Asn Tyr Ala Ser Ile Pro Gln Pro Met Thr Asp
        995                 1000                1005            
Leu Pro Glu Leu Asp Thr Pro Glu Ser Ala Arg Ile Ile Ala Phe Ile
    1010                1015                1020                
Ser Trp Leu Arg Glu Gln Arg Pro Phe Phe Pro Ile Leu Tyr Val Ile
1025                1030                1035                1040
Arg Asp Glu Ser Pro Met Lys Ala Asn Phe Leu Gln Asn Met Ile Glu
                1045                1050                1055    
Asp Arg Thr Glu Ser Ala Leu Ser Tyr Tyr Glu Phe Leu Leu His Ile
            1060                1065                1070        
Gln Gln Gln Val Asn Lys
        1075            


<210> 7803
<211> 399
<212> PRT
<213> Homo sapiens

<400> 7803
Val Asp Glu Lys Val Ile Ile Leu Val His Tyr Leu Leu Tyr Lys Tyr
 1               5                  10                  15      
Gln Met Lys Glu Pro Ile Thr Lys Ala Asp Met Leu Arg Asn Val Thr
            20                  25                  30          
Gln Met Ser Lys Ser Gln Phe Pro Val Ile Leu Ser Arg Ala Ser Glu
        35                  40                  45              
His Leu Glu Leu Ile Phe Gly Leu Asp Leu Lys Glu Val Glu Pro Asn
    50                  55                  60                  
Lys His Ile Tyr Val Leu Val Asn Lys Leu Asp Leu Gly Cys Asp Ala
65                  70                  75                  80  
Lys Leu Ser Asp Glu Thr Gly Val Pro Lys Thr Gly Leu Leu Met Thr
                85                  90                  95      
Val Leu Gly Ile Ile Phe Thr Asn Gly Asn Cys Val Ala Glu Glu Glu
            100                 105                 110         
Val Trp Lys Val Phe Asn Thr Met Gly Leu Tyr Asp Gly Ile Glu His
        115                 120                 125             
Phe Met Phe Gly Glu Pro Arg Lys Leu Leu Thr Lys Asp Leu Val Lys
    130                 135                 140                 
Glu Asn Tyr Leu Glu Tyr Gln Gln Val Pro Asn Ser Asp Pro Pro Arg
145                 150                 155                 160 
Tyr Gln Phe Leu Trp Gly Pro Arg Ala His Ala Glu Thr Ser Lys Met
                165                 170                 175     
Lys Val Leu Glu Phe Leu Ala Lys Val Asn Asp Thr Ala Pro Ser Glu
            180                 185                 190         
Phe Ser Asn Trp Ser Lys Gly Lys Asp Pro Glu Arg Thr Gly Val Lys
        195                 200                 205             
Gly Val Pro Leu Val Arg Pro Val Phe Arg Thr Glu Gly Pro Arg Lys
    210                 215                 220                 
Val Pro Pro Leu Arg Asn Pro His Gly Pro Gln Arg Ala Thr Cys Thr
225                 230                 235                 240 
Thr Thr Thr Ala Ala Ala Val Ser Tyr Val Arg Ser Asn Glu Ser Thr
                245                 250                 255     
Asn Asn Gln Thr Glu Glu Arg Pro Arg Ser Ser Gln Ala Leu Ala Ala
            260                 265                 270         
Asn Glu His Met Thr Arg Ser Pro Leu Asp Glu Lys Val Phe Ile Leu
        275                 280                 285             
Val His Tyr Leu Leu Tyr Lys Tyr Gln Met Lys Glu Leu Ile Ile Lys
    290                 295                 300                 
Ala Ala Met Leu Lys Asp Ile Val Gln Ile Pro Arg Arg Tyr Phe Ser
305                 310                 315                 320 
Glu Ile Trp Gly Lys Phe His His Leu Glu Met Val Phe Gly Leu Asp
                325                 330                 335     
Leu Lys Glu Met Asp Pro Asp Arg His Ile Tyr Phe Leu Ile Asn Thr
            340                 345                 350         
Leu Val Pro Thr Tyr Asp Ala Lys Leu Ser Asp Asp Arg Arg Val Pro
        355                 360                 365             
Arg Thr Gly Leu Leu Met Thr Ile Leu Gly Val Ile Phe Thr Asn Gly
    370                 375                 380                 
Asn Cys Ala Thr Glu Glu Gln Ile Trp Gln Val Leu Asn Val Met
385                 390                 395                 


<210> 7804
<211> 347
<212> PRT
<213> Homo sapiens

<400> 7804
Met Pro Arg Gly Gln Glu Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg
 1               5                  10                  15      
Gln Ala Arg Gly Gly Leu Glu Asp Leu Ile Asp Ala Leu Asp Ile Leu
            20                  25                  30          
Glu Glu Glu Glu Glu Ser Pro Pro Ser Ala Ser Ala Cys Leu Lys Asp
        35                  40                  45              
Val Ser Gln Ser Ser Leu Asp Gly Ala Ser Asn Asn Pro His Gly Leu
    50                  55                  60                  
Gln Glu Ala Arg Ser Thr Ser Thr Ser Ala Thr Ala Ala Ser His Thr
65                  70                  75                  80  
Arg His Pro Glu Gly Val Asn Asp Gln Met Glu Glu Arg Pro Ile Cys
                85                  90                  95      
Thr Gln Asp Leu Glu Ala Thr Asp Ser Phe Pro Arg Gly Pro Val Asp
            100                 105                 110         
Glu Lys Val Ile Ile Leu Val His Tyr Leu Leu Tyr Lys Tyr Gln Met
        115                 120                 125             
Lys Glu Pro Ile Thr Lys Ala Asp Met Leu Arg Asn Val Thr Gln Met
    130                 135                 140                 
Ser Lys Ser Gln Phe Pro Val Ile Leu Ser Arg Ala Ser Glu His Leu
145                 150                 155                 160 
Glu Leu Ile Leu Gly Leu Asp Leu Lys Glu Val Glu Pro Asn Lys His
                165                 170                 175     
Ile Tyr Val Leu Val Asn Lys Leu Asp Leu Gly Cys Asp Ala Lys Leu
            180                 185                 190         
Ser Asp Glu Thr Gly Val Pro Lys Thr Gly Leu Leu Met Thr Val Leu
        195                 200                 205             
Gly Ile Ile Phe Thr Asn Gly Asn Cys Val Ala Glu Glu Glu Val Trp
    210                 215                 220                 
Lys Val Phe Asn Thr Met Gly Leu Tyr Asp Gly Ile Glu His Phe Met
225                 230                 235                 240 
Phe Gly Glu Pro Arg Lys Leu Leu Thr Lys Asp Leu Val Lys Glu Asn
                245                 250                 255     
Tyr Leu Glu Tyr Gln Gln Val Pro Asn Ser Asp Pro Pro Arg Tyr Gln
            260                 265                 270         
Phe Leu Trp Gly Pro Arg Ala His Ala Glu Thr Ser Lys Met Lys Val
        275                 280                 285             
Leu Glu Phe Leu Ala Lys Val Asn Asp Thr Ala Pro Ser Glu Phe Ser
    290                 295                 300                 
Asn Trp Tyr Thr Glu Ala Leu Gln Asp Glu Glu Glu Arg Ala Arg Ala
305                 310                 315                 320 
Arg Val Ala Ala Lys Ala Arg Val Ser Ala Thr Ala Gly Ala Arg Ser
                325                 330                 335     
Lys Val Lys Ser Ser Lys Ser Ser Gln Leu Gln
            340                 345         


<210> 7805
<211> 860
<212> PRT
<213> Homo sapiens

<400> 7805
Met Glu Ile Gly Ser Ala Gly Pro Ala Gly Ala Gln Pro Leu Leu Met
 1               5                  10                  15      
Val Pro Arg Arg Pro Gly Tyr Gly Ala Met Gly Lys Pro Ile Lys Leu
            20                  25                  30          
Leu Ala Asn Cys Phe Gln Val Glu Ile Pro Lys Ile Asp Val Tyr Leu
        35                  40                  45              
Tyr Glu Val Asp Ile Lys Pro Asp Lys Cys Pro Arg Arg Val Asn Arg
    50                  55                  60                  
Glu Val Val Asp Ser Met Val Gln His Phe Lys Val Thr Ile Phe Gly
65                  70                  75                  80  
Asp Arg Arg Pro Val Tyr Asp Gly Lys Arg Ser Leu Tyr Thr Ala Asn
                85                  90                  95      
Pro Leu Pro Val Ala Thr Thr Gly Val Asp Leu Asp Val Thr Leu Pro
            100                 105                 110         
Gly Glu Gly Gly Lys Asp Arg Pro Phe Lys Val Ser Ile Lys Phe Val
        115                 120                 125             
Ser Arg Val Ser Trp His Leu Leu His Glu Val Leu Thr Gly Arg Thr
    130                 135                 140                 
Leu Pro Glu Pro Leu Glu Leu Asp Lys Pro Ile Ser Thr Asn Pro Val
145                 150                 155                 160 
His Ala Val Asp Val Val Leu Arg His Leu Pro Ser Met Lys Tyr Thr
                165                 170                 175     
Pro Val Gly Arg Ser Phe Phe Ser Ala Pro Glu Gly Tyr Asp His Pro
            180                 185                 190         
Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg
        195                 200                 205             
Pro Ala Met Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala
    210                 215                 220                 
Phe Tyr Lys Ala Gln Pro Val Ile Gln Phe Met Cys Glu Val Leu Asp
225                 230                 235                 240 
Ile His Asn Ile Asp Glu Gln Pro Arg Pro Leu Thr Asp Ser His Arg
                245                 250                 255     
Val Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Val Thr His
            260                 265                 270         
Cys Gly Thr Met Arg Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg
        275                 280                 285             
Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu Asn Gly Gln Thr
    290                 295                 300                 
Val Glu Arg Thr Val Ala Gln Tyr Phe Arg Glu Lys Tyr Thr Leu Gln
305                 310                 315                 320 
Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys
                325                 330                 335     
His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg
            340                 345                 350         
Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Lys Ala
        355                 360                 365             
Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Arg Leu Val
    370                 375                 380                 
Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe Val Gln Glu Phe Gln Phe
385                 390                 395                 400 
Lys Val Arg Asp Glu Met Ala His Val Thr Gly Arg Val Leu Pro Ala
                405                 410                 415     
Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg Thr Val Ala Thr Pro Ser
            420                 425                 430         
His Gly Val Trp Asp Met Arg Gly Lys Gln Phe His Thr Gly Val Glu
        435                 440                 445             
Ile Lys Met Trp Ala Ile Ala Cys Phe Ala Thr Gln Arg Gln Cys Arg
    450                 455                 460                 
Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln Leu Arg Lys Ile Ser Lys
465                 470                 475                 480 
Asp Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala
                485                 490                 495     
Gln Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr
            500                 505                 510         
Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile Leu Pro Gly Lys Thr Pro
        515                 520                 525             
Val Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Leu Leu Gly Met Ala
    530                 535                 540                 
Thr Gln Cys Val Gln Val Lys Asn Val Ile Lys Thr Ser Pro Gln Thr
545                 550                 555                 560 
Leu Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn
                565                 570                 575     
Asn Ile Leu Val Pro His Gln Arg Pro Ser Val Phe Gln Gln Pro Val
            580                 585                 590         
Ile Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys
        595                 600                 605             
Lys Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Ser
    610                 615                 620                 
Arg Tyr Cys Ala Thr Val Arg Val Gln Arg Pro Arg Gln Glu Ile Ile
625                 630                 635                 640 
Gln Asp Leu Ala Ser Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys
                645                 650                 655     
Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val
            660                 665                 670         
Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr Tyr Glu Leu Leu Ala Ile
        675                 680                 685             
Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr
    690                 695                 700                 
Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp
705                 710                 715                 720 
Arg Thr Glu Arg Val Gly Arg Ser Gly Asn Ile Pro Ala Gly Thr Thr
                725                 730                 735     
Val Asp Thr Asp Ile Thr His Pro Tyr Glu Phe Asp Phe Tyr Leu Cys
            740                 745                 750         
Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val
        755                 760                 765             
Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp Glu Leu Gln Leu Leu Thr
    770                 775                 780                 
Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile
785                 790                 795                 800 
Pro Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr
                805                 810                 815     
His Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Val Ser
            820                 825                 830         
Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln
        835                 840                 845             
Ile His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala
    850                 855                 860 


<210> 7806
<211> 626
<212> PRT
<213> Homo sapiens

<400> 7806
Met Cys Glu Val Leu Asp Ile His Asn Ile Asp Glu Gln Pro Arg Pro
 1               5                  10                  15      
Leu Thr Asp Ser His Arg Val Lys Phe Thr Lys Glu Ile Lys Gly Leu
            20                  25                  30          
Lys Val Glu Val Thr His Cys Gly Thr Met Arg Arg Lys Tyr Arg Val
        35                  40                  45              
Cys Asn Val Thr Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln
    50                  55                  60                  
Leu Glu Asn Gly Gln Thr Val Glu Arg Thr Val Ala Gln Tyr Phe Arg
65                  70                  75                  80  
Glu Lys Tyr Thr Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln
                85                  90                  95      
Val Gly Gln Glu Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn
            100                 105                 110         
Ile Val Ala Gly Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr
        115                 120                 125             
Ser Thr Met Ile Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu
    130                 135                 140                 
Glu Ile Ser Arg Leu Val Arg Ser Ala Asn Tyr Glu Thr Asp Pro Phe
145                 150                 155                 160 
Val Gln Glu Phe Gln Phe Lys Val Arg Asp Glu Met Ala His Val Thr
                165                 170                 175     
Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn Arg
            180                 185                 190         
Thr Val Ala Thr Pro Ser His Gly Val Trp Asp Met Arg Gly Lys Gln
        195                 200                 205             
Phe His Thr Gly Val Glu Ile Lys Met Trp Ala Ile Ala Cys Phe Ala
    210                 215                 220                 
Thr Gln Arg Gln Cys Arg Glu Glu Ile Leu Lys Gly Phe Thr Asp Gln
225                 230                 235                 240 
Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro
                245                 250                 255     
Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe
            260                 265                 270         
Arg His Leu Lys Asn Thr Tyr Ser Gly Leu Gln Leu Ile Ile Val Ile
        275                 280                 285             
Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp
    290                 295                 300                 
Thr Leu Leu Gly Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Ile
305                 310                 315                 320 
Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Val
                325                 330                 335     
Lys Leu Gly Gly Ile Asn Asn Ile Leu Val Pro His Gln Arg Pro Ser
            340                 345                 350         
Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro
        355                 360                 365             
Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly Ser
    370                 375                 380                 
Met Asp Ala His Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Arg
385                 390                 395                 400 
Pro Arg Gln Glu Ile Ile Gln Asp Leu Ala Ser Met Val Arg Glu Leu
                405                 410                 415     
Leu Ile Gln Phe Tyr Lys Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile
            420                 425                 430         
Phe Tyr Arg Asp Gly Val Ser Glu Gly Gln Phe Arg Gln Val Leu Tyr
        435                 440                 445             
Tyr Glu Leu Leu Ala Ile Arg Glu Ala Cys Ile Ser Leu Glu Lys Asp
    450                 455                 460                 
Tyr Gln Pro Gly Ile Thr Tyr Ile Val Val Gln Lys Arg His His Thr
465                 470                 475                 480 
Arg Leu Phe Cys Ala Asp Arg Thr Glu Arg Val Gly Arg Ser Gly Asn
                485                 490                 495     
Ile Pro Ala Gly Thr Thr Val Asp Thr Asp Ile Thr His Pro Tyr Glu
            500                 505                 510         
Phe Asp Phe Tyr Leu Cys Ser His Ala Gly Ile Gln Gly Thr Ser Arg
        515                 520                 525             
Pro Ser His Tyr His Val Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp
    530                 535                 540                 
Glu Leu Gln Leu Leu Thr Tyr Gln Leu Cys His Thr Tyr Val Arg Cys
545                 550                 555                 560 
Thr Arg Ser Val Ser Ile Pro Ala Pro Ala Tyr Tyr Ala His Leu Val
                565                 570                 575     
Ala Phe Arg Ala Arg Tyr His Leu Val Asp Lys Glu His Asp Ser Ala
            580                 585                 590         
Glu Gly Ser His Val Ser Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala
        595                 600                 605             
Leu Ala Lys Ala Val Gln Ile His Gln Asp Thr Leu Arg Thr Met Tyr
    610                 615                 620                 
Phe Ala
625     


<210> 7807
<211> 2095
<212> PRT
<213> Homo sapiens

<400> 7807
Met Ala Asp Ala Asp Ile Leu Ser Glu Thr Phe Gln Leu Leu Ile Asp
 1               5                  10                  15      
Ser Ala Lys Asp Phe Ser Lys Arg Leu Trp Gly Leu Val Pro Phe Gly
            20                  25                  30          
Leu Tyr Leu Pro Ala Pro Pro Leu Tyr Cys Pro Gln Pro Ala Ile Leu
        35                  40                  45              
Ser Glu Glu Asp Gly Asp Asp Leu Leu Leu Lys Ala Glu Lys Asn Asn
    50                  55                  60                  
Arg Gln Lys Val Ser Gly Ile Leu Gln Arg Val Leu Leu Leu Phe Arg
65                  70                  75                  80  
Ala Ala Gln Cys Ser Phe Pro Val Ala Gln Trp Tyr Ile Leu Gln Leu
                85                  90                  95      
Arg Trp Ala Arg Lys Val Met Gln Lys Ile Arg Met Lys Gly Ser Leu
            100                 105                 110         
Pro Ser Leu Ser Pro Phe Pro Gln Ser Leu Leu Asn Tyr Cys Lys Gly
        115                 120                 125             
Gly Ile Ala Phe Phe Arg Pro Gly Ala Ala Gly Asp His Lys Leu Asp
    130                 135                 140                 
Glu Val Ser Ile Arg Ala Ile Gly Cys Phe Arg Glu Leu Cys Ala Leu
145                 150                 155                 160 
Cys Trp Met Leu His Val Arg Asp Lys Leu Ser Tyr Ser Cys Arg Gln
                165                 170                 175     
Tyr Gln Lys Ala Arg Glu Asn Val Lys Gly Glu Lys Asp Leu Glu Val
            180                 185                 190         
Glu Phe Asp Ser Cys Met Ile Glu His Cys Leu Ser Ala Val Glu Trp
        195                 200                 205             
Ala Tyr Arg Met Leu Pro Phe Ser Arg Phe Phe Asn Met Glu Glu Leu
    210                 215                 220                 
Ile Gln Asp Ile Ile Leu Ser Leu Ile Gly Glu Leu Pro Pro Ile Arg
225                 230                 235                 240 
Lys Val Ala Glu Ile Phe Val Lys Ala Phe Pro Tyr Pro Glu Asp Val
                245                 250                 255     
Arg Val Pro Leu Arg Asp Lys Tyr His Ser Leu His Gln Arg Leu Arg
            260                 265                 270         
His Cys Val Val Lys Gly Pro Gln Thr Glu Glu Met Met Ser Val Val
        275                 280                 285             
Met His Ser Ile Gln Lys Val Arg Val Lys Ala Leu Lys Arg Val Arg
    290                 295                 300                 
Arg Asn Ile Gly Ser Phe Glu Val Asn Ile Trp Glu Pro Ile Glu Glu
305                 310                 315                 320 
Glu Lys Pro Asp Glu Ala Pro Gly Val Asp Arg Tyr Ser Leu Gly Thr
                325                 330                 335     
Ser Leu Ser Arg Ser Thr Leu Thr Glu Leu Gly Asp Ser Val Val His
            340                 345                 350         
Ser Asp Ala Asp Thr Phe Ser Glu Ala Leu Ser Val Glu Glu Lys Ser
        355                 360                 365             
Arg Ile Asn Ile Tyr Gln Arg Asn Ala Pro Asn His Met Glu Leu Thr
    370                 375                 380                 
Ser Ile His Lys Pro Thr Asp Lys Arg Lys Met Cys Asn Gln Lys Glu
385                 390                 395                 400 
Asn Pro Thr Lys Lys Glu Asp His Glu Lys Leu Ser Gln Asn Thr Leu
                405                 410                 415     
Pro Val Ile Gly Val Trp Glu Phe Glu Arg Asp Asp Asp Glu Tyr Ile
            420                 425                 430         
Lys Phe Leu Asp Leu Phe Leu Ser Tyr Ile Leu Glu Arg Asp Leu Pro
        435                 440                 445             
Tyr Ser Arg Asp Ala Asp Ile Pro Phe Leu Thr Ser Phe Ser Gly Lys
    450                 455                 460                 
Leu Arg Glu His Glu Leu Asn Ser Leu Leu Phe Asp Val His Thr Thr
465                 470                 475                 480 
Leu Lys Arg His Gln Ser Lys Thr Lys Ser Gln Asn Val Phe Arg Ala
                485                 490                 495     
Gly Ser Cys Phe Val Val Ala Pro Glu Ser Tyr Glu Ser Glu Lys Ser
            500                 505                 510         
Ser Ser Leu Asn Asp Glu Tyr Gly Met His Leu Glu Asn Gln Lys Leu
        515                 520                 525             
Ser Ser Ser Val Leu Val Asn Gln Gly Ile Lys Pro Phe Leu Gln Tyr
    530                 535                 540                 
Pro Ser Asn Glu Val Asn Lys Asn Glu Gly Met Ser Gly Leu Phe Gly
545                 550                 555                 560 
Leu Lys Gln Arg Ser Ile Tyr Lys Ile Gln Asp Asp Thr Arg Glu Lys
                565                 570                 575     
Cys Leu Ile Gln Arg Ser Ser Asn His Ile Phe Trp Thr Pro Lys Ser
            580                 585                 590         
Ile Lys Thr Arg Arg Cys Ile Phe Lys Ala Ile Gln Cys Asn Asp Ile
        595                 600                 605             
Asn Pro Gln Glu Asp Leu Pro Leu Ala Leu Asn Thr Phe Gly Ser Ile
    610                 615                 620                 
Gly Arg Leu Leu Glu Trp Met Ile Arg Trp Ser Asn Arg Arg Leu Leu
625                 630                 635                 640 
Cys Asp Ser Gly Ile Thr Glu Ser Ser Ser Glu Tyr Ser Pro Val Ile
                645                 650                 655     
Arg Val Lys Thr Ser Thr Ala Ala Ile Leu Thr Ser Leu Trp Leu Leu
            660                 665                 670         
Glu Gln Pro Tyr Phe Ala Thr Tyr Lys Ala Lys Asn Ala Ile Ile Lys
        675                 680                 685             
Met Val Glu Asn Arg Asp Thr Gly Cys Gln Ile Gly Pro Asn Ile Glu
    690                 695                 700                 
Arg Glu Ser Lys Ser Asp Ala Gly Gly Ser Val Ala Val Ala Thr Pro
705                 710                 715                 720 
Gly Gly Thr Glu Glu Arg Asn Gly Gln Asn Lys Ser Cys Gln Asn Ile
                725                 730                 735     
Leu Lys Met Pro Thr Glu Ala Lys Asn Pro Asp Ile Lys Glu Ile Asn
            740                 745                 750         
Asp Asp Ile Ile Ser Ile Thr His Asn Thr Lys Lys Glu Phe Ile Asp
        755                 760                 765             
Ile Asp Glu Asn Leu Leu Glu Val Glu Ala Phe Thr Glu Glu Glu Met
    770                 775                 780                 
Asp Met His Ile Ser Asp Tyr Glu Glu Asp Ile Glu Glu Ser Val Gly
785                 790                 795                 800 
Gly Phe Arg Ser Pro Ser Leu Ala Ile Cys Met Met Thr Leu Pro Gln
                805                 810                 815     
Gln Leu Glu Glu Glu Phe Thr Glu Glu Val Gln Cys Gln Arg Glu Glu
            820                 825                 830         
Pro Leu Glu Thr Ile Met Glu Glu Lys Ser Thr Glu Gln Lys Gly Met
        835                 840                 845             
Ile Glu Ala Phe Ser His Pro Gly His Thr Thr Pro Gln Ser Met Gln
    850                 855                 860                 
Val Asp Thr Ser Ser Glu Ile Ser Ser Ala Gln Ile Ser Thr Tyr Lys
865                 870                 875                 880 
Glu Lys Ser Ser Ser Val Pro Leu Leu Ile Ser Asn Gly Val Asn Val
                885                 890                 895     
Ala Ser Gln Pro Pro Ala Pro Thr Pro Gln Lys Thr Gln Arg Asn Glu
            900                 905                 910         
Phe Thr Ala Gln Leu Pro Asp Cys Ser Glu Ser Val Arg Gln Met Leu
        915                 920                 925             
Gln Asp Glu Met Phe Lys Leu Val Gln Leu Gln Gln Ile Asn Phe Met
    930                 935                 940                 
Ser Leu Met Gln Ile Val Gly Ser Ser Phe Ala Asn Leu Pro Asp Thr
945                 950                 955                 960 
Gln Gln Leu Val Gln Gln Ser Gln Ser Val His Leu Gly Glu Ser Gln
                965                 970                 975     
Glu Ser Asn Leu Arg Gly Cys Gly Asp Val Glu Asp Ser Asn Lys Asn
            980                 985                 990         
Leu Lys Glu Arg Phe Phe Ile Lys Pro Gln Ser Met Gly Glu Asn Ala
        995                 1000                1005            
Arg Glu Pro Arg Lys Asn Ser Pro His Cys His Glu Gly Thr Ile Pro
    1010                1015                1020                
Ser Gly Gln Asn Ser Thr Gly Asn Val Gln Asn Val Pro His Gly Ser
1025                1030                1035                1040
Ile Pro Leu Cys Gln Leu Asn Gly Gln Pro Arg Lys Lys Gly Pro Ile
                1045                1050                1055    
Pro Ser Ser Gln Asn Leu Pro Ser Thr Ser Phe Tyr Pro Ala Pro Ala
            1060                1065                1070        
Gly Asn Thr His Leu Tyr Leu Leu Ser Thr Pro Ser Val Val Gln Lys
        1075                1080                1085            
Ala Pro Arg Leu Ile Pro His Ala Lys Thr Phe Ser Pro Gly Asp Gly
    1090                1095                1100                
Phe Pro Leu Leu Gln Phe Lys Ser Lys Gln Glu Phe Gln Pro Leu Phe
1105                1110                1115                1120
Leu His Thr Gly Ser Ile Pro Gln Val Pro Phe Arg Pro Leu Pro Gln
                1125                1130                1135    
Pro Arg Glu Ala Trp Gly Leu Ser Asp Ser Phe Gln Pro Ala Leu Pro
            1140                1145                1150        
Gln Arg Ala Ala Gln Thr Thr Pro Ala Ser His Leu Asn Val Ser Gln
        1155                1160                1165            
Tyr Asn Thr Glu Ala Arg Lys Lys Glu Val Glu Gln Lys Thr Trp Ala
    1170                1175                1180                
Glu Thr Val Ile Thr Glu Ile Pro Asn His Val Asn Leu Asp Gln Tyr
1185                1190                1195                1200
Val Gly Gln Glu Asn Leu Thr Pro Gln Gln Asp Ser Ser Val Phe Ile
                1205                1210                1215    
Lys Pro Glu Lys Leu Phe Asp Val Lys Pro Gly Thr Leu Glu Ile Ser
            1220                1225                1230        
Pro His His Ser Phe Gly Leu Pro Leu Leu Tyr Leu Pro Leu Lys Pro
        1235                1240                1245            
Pro Asn Met Phe Pro Ser Thr Ser Arg Ala Ser Ile Thr Val Pro Ser
    1250                1255                1260                
Thr Pro Ile Gln Pro Ile Ala Glu Glu Arg Lys Tyr Pro Arg Leu Ser
1265                1270                1275                1280
Leu Leu His Ser His Leu Ser Pro Glu Asn Arg Cys Lys Lys Thr Gln
                1285                1290                1295    
Leu Ile Pro Leu Glu Asn Leu Ile Ala Phe Lys Gln Ser Gln Gln Lys
            1300                1305                1310        
Leu Thr His Asn Leu Phe Glu Gln Gly Asp Ala Gly His Leu Gln Leu
        1315                1320                1325            
Leu Lys Val Lys Ile Glu Pro Pro Glu Val Arg Gln Gly Lys Asp Ser
    1330                1335                1340                
Lys Lys Arg Gln Arg Arg Arg Ala Glu Lys Glu Leu Gln Glu Lys Arg
1345                1350                1355                1360
Cys Glu Lys Leu Arg Arg Lys Pro Asn Val Thr Phe Arg Pro Glu Asn
                1365                1370                1375    
Ser Ile Ile Asn Asn Asp Asp Ser Glu Ile Ile Lys Lys Pro Lys Glu
            1380                1385                1390        
Gln Gln Glu His Cys Gly Ser His Pro Leu Asp Asp Phe Asp Val Pro
        1395                1400                1405            
Phe Glu Met Leu Gln Asp Asp Asn Thr Ser Ala Gly Leu His Phe Met
    1410                1415                1420                
Ala Ser Val Lys Lys Lys Ala Ile Gly Ser Gln Asp Ala Ser Thr Asn
1425                1430                1435                1440
Thr Asp Pro Glu His Glu Pro Leu Thr Ala Pro Gln Leu Leu Val Pro
                1445                1450                1455    
Asp Val Tyr Leu Asn Leu Lys Leu Ser Ser Glu Met Ser Glu Lys Pro
            1460                1465                1470        
Trp Ser Pro Ser Ile Pro His Thr Val Thr Asn Leu Val Gly His Thr
        1475                1480                1485            
Tyr Ile Asn Val Ile Asp Ile Glu Ala Asn Asp Leu Leu Gln Glu Leu
    1490                1495                1500                
Pro Val Arg Glu Glu Pro Ser Asn Asp Asn Val Ile Lys Gln Gln Ser
1505                1510                1515                1520
Asp His Leu Ala Val Pro Ser Ser Ala Glu Leu His Tyr Met Ala Ala
                1525                1530                1535    
Ser Val Thr Asn Ala Val Pro Pro His Asn Phe Lys Ser Gln Gly Leu
            1540                1545                1550        
Pro Lys Pro Glu Phe Arg Phe Lys Gly Gln Ser Thr Lys Ser Asp Ser
        1555                1560                1565            
Ala Glu Asp Tyr Leu Leu Trp Lys Arg Leu Gln Gly Val Ser Ala Ala
    1570                1575                1580                
Cys Pro Ala Pro Ser Ser Ala Ala His Gln Leu Glu His Leu Ser Ala
1585                1590                1595                1600
Lys Leu Gln Lys Ile Asp Glu Gln Leu Leu Ala Ile Gln Asn Ile Ala
                1605                1610                1615    
Glu Asn Ile Glu Gln Asp Phe Pro Lys Pro Glu Met Leu Asp Leu His
            1620                1625                1630        
Cys Asp Lys Ile Gly Pro Val Asp His Ile Glu Phe Ser Ser Gly Pro
        1635                1640                1645            
Glu Phe Lys Lys Thr Leu Ala Ser Lys Thr Ile Ser Ile Ser Glu Glu
    1650                1655                1660                
Val Arg Phe Leu Thr His Met Asp Glu Glu Asp Gln Ser Asp Lys Lys
1665                1670                1675                1680
Glu Thr Ser Glu Pro Glu Phe Ser Ile Thr Glu Asn Tyr Ser Gly Gln
                1685                1690                1695    
Lys Thr Cys Val Phe Pro Thr Ala Asp Ser Ala Val Ser Leu Ser Ser
            1700                1705                1710        
Ser Ser Asp Gln Asn Thr Thr Ser Pro Gly Met Asn Ser Ser Asp Glu
        1715                1720                1725            
Leu Cys Glu Ser Val Ser Val His Pro Leu Gln Met Thr Gly Leu Thr
    1730                1735                1740                
Asp Ile Ala Asp Ile Ile Asp Asp Leu Ile Ile Lys Asp Gly Val Ser
1745                1750                1755                1760
Ser Glu Glu Leu Gly Leu Thr Glu Gln Ala Met Gly Thr Ser Arg Ile
                1765                1770                1775    
Gln His Tyr Ser Gly Arg His Ser Gln Arg Thr Asp Lys Glu Arg Arg
            1780                1785                1790        
Glu Ile Gln Ala Trp Met Lys Arg Lys Arg Lys Glu Arg Met Ala Lys
        1795                1800                1805            
Tyr Leu Asn Glu Leu Ala Glu Lys Arg Gly Gln Glu His Asp Pro Phe
    1810                1815                1820                
Cys Pro Arg Ser Asn Pro Leu Tyr Met Thr Ser Arg Glu Ile Arg Leu
1825                1830                1835                1840
Arg Gln Lys Met Lys His Glu Lys Asp Arg Leu Leu Leu Ser Glu His
                1845                1850                1855    
Tyr Ser Arg Arg Ile Ser Gln Ala Tyr Gly Leu Met Asn Glu Leu Leu
            1860                1865                1870        
Ser Glu Ser Val Gln Leu Pro Thr Leu Pro Gln Lys Pro Leu Pro Asn
        1875                1880                1885            
Lys Pro Ser Pro Thr Gln Ser Ser Ser Cys Gln His Cys Pro Ser Pro
    1890                1895                1900                
Arg Gly Glu Asn Gln His Gly His Ser Phe Leu Ile Asn Arg Pro Gly
1905                1910                1915                1920
Lys Val Lys Tyr Met Ser Lys Pro Ser Tyr Ile His Lys Arg Lys Ser
                1925                1930                1935    
Phe Gly Gln Pro Gln Gly Ser Pro Trp Pro His Gly Thr Ala Thr Phe
            1940                1945                1950        
Thr Ile Gln Lys Lys Ala Gly Gly Ala Lys Ala Ala Val Arg Lys Ala
        1955                1960                1965            
Thr Gln Ser Pro Val Thr Phe Gln Lys Gly Ser Asn Ala Pro Cys His
    1970                1975                1980                
Ser Leu Gln His Thr Lys Lys His Gly Ser Ala Gly Leu Ala Pro Gln
1985                1990                1995                2000
Thr Lys Gln Val Cys Val Glu Tyr Glu Arg Glu Glu Thr Val Val Ser
                2005                2010                2015    
Pro Trp Thr Ile Pro Ser Glu Ile His Lys Ile Leu His Glu Ser His
            2020                2025                2030        
Asn Ser Leu Leu Gln Asp Leu Ser Pro Thr Glu Glu Glu Glu Pro Glu
        2035                2040                2045            
His Pro Phe Gly Val Gly Gly Val Asp Ser Val Ser Glu Ser Thr Gly
    2050                2055                2060                
Ser Ile Leu Ser Lys Leu Asp Trp Asn Ala Ile Glu Asp Met Val Ala
2065                2070                2075                2080
Ser Val Glu Asp Gln Gly Leu Ser Val His Trp Ala Leu Asp Leu
                2085                2090                2095


<210> 7808
<211> 919
<212> PRT
<213> Homo sapiens

<400> 7808
Met Ala Ser Ala Thr Ala Ala Ala Ala Arg Arg Gly Leu Gly Arg Ala
 1               5                  10                  15      
Leu Pro Leu Leu Trp Arg Gly Tyr Gln Thr Glu Arg Gly Val Tyr Gly
            20                  25                  30          
Tyr Arg Pro Arg Lys Pro Glu Ser Arg Glu Pro Gln Gly Ala Leu Glu
        35                  40                  45              
Arg Pro Pro Val Asp His Gly Leu Ala Arg Leu Val Thr Val Tyr Cys
    50                  55                  60                  
Glu His Gly His Lys Ala Ala Lys Ile Asn Pro Leu Phe Thr Gly Gln
65                  70                  75                  80  
Ala Leu Leu Glu Asn Val Pro Glu Ile Gln Ala Leu Val Gln Thr Leu
                85                  90                  95      
Gln Gly Pro Phe His Thr Ala Gly Leu Leu Asn Met Gly Lys Glu Glu
            100                 105                 110         
Ala Ser Leu Glu Glu Val Leu Val Tyr Leu Asn Gln Ile Tyr Cys Gly
        115                 120                 125             
Gln Ile Ser Ile Glu Thr Ser Gln Leu Gln Ser Gln Asp Glu Lys Asp
    130                 135                 140                 
Trp Phe Ala Lys Arg Phe Glu Glu Leu Gln Lys Glu Thr Phe Thr Thr
145                 150                 155                 160 
Glu Glu Arg Lys His Leu Ser Lys Leu Met Leu Glu Ser Gln Glu Phe
                165                 170                 175     
Asp His Phe Leu Ala Thr Lys Phe Ser Thr Val Lys Arg Tyr Gly Gly
            180                 185                 190         
Glu Gly Ala Glu Ser Met Met Gly Phe Phe His Glu Leu Leu Lys Met
        195                 200                 205             
Ser Ala Tyr Ser Gly Ile Thr Asp Val Ile Ile Gly Met Pro His Arg
    210                 215                 220                 
Gly Arg Leu Asn Leu Leu Thr Gly Leu Leu Gln Phe Pro Pro Glu Leu
225                 230                 235                 240 
Met Phe Arg Lys Met Arg Gly Leu Ser Glu Phe Pro Glu Asn Phe Ser
                245                 250                 255     
Ala Thr Gly Asp Val Leu Ser His Leu Thr Ser Ser Val Asp Leu Tyr
            260                 265                 270         
Phe Gly Ala His His Pro Leu His Val Thr Met Leu Pro Asn Pro Ser
        275                 280                 285             
His Leu Glu Ala Val Asn Pro Val Ala Val Gly Lys Thr Arg Gly Arg
    290                 295                 300                 
Gln Gln Ser Arg Gln Asp Gly Asp Tyr Ser Pro Asp Asn Ser Ala Gln
305                 310                 315                 320 
Pro Gly Asp Arg Val Ile Cys Leu Gln Val His Gly Asp Ala Ser Phe
                325                 330                 335     
Cys Gly Gln Gly Ile Val Pro Glu Thr Phe Thr Leu Ser Asn Leu Pro
            340                 345                 350         
His Phe Arg Ile Gly Gly Ser Val His Leu Ile Val Asn Asn Gln Leu
        355                 360                 365             
Gly Tyr Thr Thr Pro Ala Glu Arg Gly Arg Ser Ser Leu Tyr Cys Ser
    370                 375                 380                 
Asp Ile Gly Lys Leu Val Gly Cys Ala Ile Ile His Val Asn Gly Asp
385                 390                 395                 400 
Ser Pro Glu Glu Val Val Arg Ala Thr Arg Leu Ala Phe Glu Tyr Gln
                405                 410                 415     
Arg Gln Phe Arg Lys Asp Val Ile Ile Asp Leu Leu Cys Tyr Arg Gln
            420                 425                 430         
Trp Gly His Asn Glu Leu Asp Glu Pro Phe Tyr Thr Asn Pro Ile Met
        435                 440                 445             
Tyr Lys Ile Ile Arg Ala Arg Lys Ser Ile Pro Asp Thr Tyr Ala Glu
    450                 455                 460                 
His Leu Ile Ala Gly Gly Leu Met Thr Gln Glu Glu Val Ser Glu Ile
465                 470                 475                 480 
Lys Ser Ser Tyr Tyr Ala Lys Leu Asn Asp His Leu Asn Asn Met Ala
                485                 490                 495     
His Tyr Arg Pro Pro Ala Leu Asn Leu Gln Ala His Trp Gln Gly Leu
            500                 505                 510         
Ala Gln Pro Glu Ala Gln Ile Thr Thr Trp Ser Thr Gly Val Pro Leu
        515                 520                 525             
Asp Leu Leu Arg Phe Val Gly Met Lys Ser Val Glu Val Pro Arg Glu
    530                 535                 540                 
Leu Gln Met His Ser His Leu Leu Lys Thr His Val Gln Ser Arg Met
545                 550                 555                 560 
Glu Lys Met Met Asp Gly Ile Lys Leu Asp Trp Ala Thr Ala Glu Ala
                565                 570                 575     
Leu Ala Leu Gly Ser Leu Leu Ala Gln Gly Phe Asn Val Arg Leu Ser
            580                 585                 590         
Gly Gln Asp Val Gly Arg Gly Thr Phe Ser Gln Arg His Ala Ile Val
        595                 600                 605             
Val Cys Gln Glu Thr Asp Asp Thr Tyr Ile Pro Leu Asn His Met Asp
    610                 615                 620                 
Pro Asn Gln Lys Gly Phe Leu Glu Val Ser Asn Ser Pro Leu Ser Glu
625                 630                 635                 640 
Glu Ala Val Leu Gly Phe Glu Tyr Gly Met Ser Ile Glu Ser Pro Lys
                645                 650                 655     
Leu Leu Pro Leu Trp Glu Ala Gln Phe Gly Asp Phe Phe Asn Gly Ala
            660                 665                 670         
Gln Ile Ile Phe Asp Thr Phe Ile Ser Gly Gly Glu Ala Lys Trp Leu
        675                 680                 685             
Leu Gln Ser Gly Ile Val Ile Leu Leu Pro His Gly Tyr Asp Gly Ala
    690                 695                 700                 
Gly Pro Asp His Ser Ser Cys Arg Ile Glu Arg Phe Leu Gln Met Cys
705                 710                 715                 720 
Asp Ser Ala Glu Glu Gly Val Asp Gly Asp Thr Val Asn Met Phe Val
                725                 730                 735     
Val His Pro Thr Thr Pro Ala Gln Tyr Phe His Leu Leu Arg Arg Gln
            740                 745                 750         
Met Val Arg Asn Phe Arg Lys Pro Leu Ile Val Ala Ser Pro Lys Met
        755                 760                 765             
Leu Leu Arg Leu Pro Ala Ala Val Ser Thr Leu Gln Glu Met Ala Pro
    770                 775                 780                 
Gly Thr Thr Phe Asn Pro Val Ile Gly Asp Ser Ser Val Asp Pro Lys
785                 790                 795                 800 
Lys Val Lys Thr Leu Val Phe Cys Ser Gly Lys His Phe Tyr Ser Leu
                805                 810                 815     
Val Lys Gln Arg Glu Ser Leu Gly Ala Lys Lys His Asp Phe Ala Ile
            820                 825                 830         
Ile Arg Val Glu Glu Leu Cys Pro Phe Pro Leu Asp Ser Leu Gln Gln
        835                 840                 845             
Glu Met Ser Lys Tyr Lys His Val Lys Asp His Ile Trp Ser Gln Glu
    850                 855                 860                 
Glu Pro Gln Asn Met Gly Pro Trp Ser Phe Val Ser Pro Arg Phe Glu
865                 870                 875                 880 
Lys Gln Leu Ala Cys Lys Leu Arg Leu Val Gly Arg Pro Pro Leu Pro
                885                 890                 895     
Val Pro Ala Val Gly Ile Gly Thr Val His Leu His Gln His Glu Asp
            900                 905                 910         
Ile Leu Ala Lys Thr Phe Ala
        915                 


<210> 7809
<211> 179
<212> PRT
<213> Homo sapiens

<400> 7809
Met Ala Ser Leu Met Gly Phe Ser Gly Gly Cys Tyr Cys Arg Val Ser
 1               5                  10                  15      
Gly Thr Asp Tyr Tyr Cys Ser Ala Leu Glu Met Leu Asn Leu Ser Ser
            20                  25                  30          
Tyr Pro Ile Trp Val Ser Leu Phe Arg Gly Ser Pro Arg Arg Ala Ala
        35                  40                  45              
Ser Cys Gln Tyr Pro Leu Ser Leu Gln His Pro Ser Ser Ser Ser Pro
    50                  55                  60                  
Thr Trp Thr Gln Asp Pro Glu Pro Thr Glu Gly Met Glu Arg Thr Ser
65                  70                  75                  80  
Arg Ala Pro Gln Val Gly Gly Pro Ile Pro Trp Gly Gln Ala His Leu
                85                  90                  95      
Arg Thr Ser Leu Glu Leu Gln Gly Cys Glu Ser Gln Pro His Thr Ala
            100                 105                 110         
Leu Thr Pro Ala Pro Leu Ser Gln Thr Leu Arg Leu Leu Ser Ser Phe
        115                 120                 125             
Ala Ile Arg Cys Ser Ile Leu Gly Lys Leu Gly Trp Glu Arg Leu His
    130                 135                 140                 
Lys Thr Ser Leu Leu Pro Leu Thr Leu Ala Pro Pro Ile Ser Gly Ser
145                 150                 155                 160 
Arg Pro Gly Asp Ala Thr Ser Ser Val Cys Pro Ala Val Ser Phe Tyr
                165                 170                 175     
Val Gly Glu
            


<210> 7810
<211> 224
<212> PRT
<213> Homo sapiens

<400> 7810
Met Thr Ser Glu Val Ile Glu Asp Glu Lys Gln Phe Tyr Ser Lys Ala
 1               5                  10                  15      
Lys Thr Tyr Trp Lys Gln Ile Pro Pro Thr Val Asp Gly Met Leu Gly
            20                  25                  30          
Gly Tyr Gly His Ile Ser Ser Ser Ile Asp Ile Asn Ser Ser Arg Lys
        35                  40                  45              
Phe Leu Gln Arg Phe Leu Arg Glu Gly Pro Asn Lys Thr Gly Thr Ser
    50                  55                  60                  
Cys Ala Leu Asp Cys Gly Ala Gly Ile Gly Arg Ile Thr Lys Arg Leu
65                  70                  75                  80  
Leu Leu Pro Leu Phe Arg Glu Val Asp Met Val Asp Ile Thr Glu Asp
                85                  90                  95      
Phe Leu Val Gln Ala Lys Thr Tyr Leu Gly Glu Glu Gly Lys Arg Val
            100                 105                 110         
Arg Asn Tyr Phe Cys Cys Gly Leu Gln Asp Phe Thr Pro Glu Pro Asp
        115                 120                 125             
Ser Tyr Asp Val Ile Trp Ile Gln Trp Val Ile Gly His Leu Thr Asp
    130                 135                 140                 
Gln His Leu Ala Glu Phe Leu Arg Arg Cys Lys Gly Ser Leu Arg Pro
145                 150                 155                 160 
Asn Gly Ile Ile Val Ile Lys Asp Asn Met Ala Gln Glu Gly Val Ile
                165                 170                 175     
Leu Asp Asp Val Asp Ser Ser Val Cys Arg Asp Leu Asp Val Val Arg
            180                 185                 190         
Arg Ile Ile Cys Ser Ala Gly Leu Ser Leu Leu Ala Glu Glu Arg Gln
        195                 200                 205             
Glu Asn Leu Pro Asp Glu Ile Tyr His Val Tyr Ser Phe Ala Leu Arg
    210                 215                 220                 


<210> 7811
<211> 405
<212> PRT
<213> Homo sapiens

<400> 7811
Met Phe Val Gln Glu Glu Lys Ile Phe Ala Gly Lys Val Leu Arg Leu
 1               5                  10                  15      
His Ile Cys Ala Ser Asp Gly Ala Glu Trp Leu Glu Glu Ala Thr Glu
            20                  25                  30          
Asp Thr Ser Val Glu Lys Leu Lys Glu Arg Cys Leu Lys His Cys Ala
        35                  40                  45              
His Gly Ser Leu Glu Asp Pro Lys Ser Ile Thr His His Lys Leu Ile
    50                  55                  60                  
His Ala Ala Ser Glu Arg Val Leu Ser Asp Ala Arg Thr Ile Leu Glu
65                  70                  75                  80  
Glu Asn Ile Gln Asp Gln Asp Val Leu Leu Leu Ile Lys Lys Arg Ala
                85                  90                  95      
Pro Ser Pro Leu Pro Lys Met Ala Asp Val Ser Ala Glu Glu Lys Lys
            100                 105                 110         
Lys Gln Asp Gln Lys Ala Pro Asp Lys Glu Ala Ile Leu Arg Ala Thr
        115                 120                 125             
Ala Asn Leu Pro Ser Tyr Asn Met Asp Arg Ala Ala Val Gln Thr Asn
    130                 135                 140                 
Met Arg Asp Phe Gln Thr Glu Leu Arg Lys Ile Leu Val Ser Leu Ile
145                 150                 155                 160 
Glu Val Ala Gln Lys Leu Leu Ala Leu Asn Pro Asp Ala Val Glu Leu
                165                 170                 175     
Phe Lys Lys Ala Asn Ala Met Leu Asp Glu Asp Glu Asp Glu Arg Val
            180                 185                 190         
Asp Glu Ala Ala Leu Arg Gln Leu Thr Glu Met Gly Phe Pro Glu Asn
        195                 200                 205             
Arg Ala Thr Lys Ala Leu Gln Leu Asn His Met Ser Val Pro Gln Ala
    210                 215                 220                 
Met Glu Trp Leu Ile Glu His Ala Glu Asp Pro Thr Ile Asp Thr Pro
225                 230                 235                 240 
Leu Pro Gly Gln Ala Pro Pro Glu Ala Glu Gly Ala Thr Ala Ala Ala
                245                 250                 255     
Ser Glu Ala Ala Ala Gly Ala Ser Ala Thr Asp Glu Glu Ala Arg Asp
            260                 265                 270         
Glu Leu Thr Glu Ile Phe Lys Lys Ile Arg Arg Lys Arg Glu Phe Arg
        275                 280                 285             
Ala Asp Ala Arg Ala Val Ile Ser Leu Met Glu Met Gly Phe Asp Glu
    290                 295                 300                 
Lys Glu Val Ile Asp Ala Leu Arg Val Asn Asn Asn Gln Gln Asn Ala
305                 310                 315                 320 
Ala Cys Glu Trp Leu Leu Gly Asp Arg Lys Pro Ser Pro Glu Glu Leu
                325                 330                 335     
Asp Lys Gly Ile Asp Pro Asp Ser Pro Leu Phe Gln Ala Ile Leu Asp
            340                 345                 350         
Asn Pro Val Val Gln Leu Gly Leu Thr Asn Pro Lys Thr Leu Leu Ala
        355                 360                 365             
Phe Glu Asp Met Leu Glu Asn Pro Leu Asn Ser Thr Gln Trp Met Asn
    370                 375                 380                 
Asp Pro Glu Thr Gly Pro Val Met Leu Gln Ile Ser Arg Ile Phe Gln
385                 390                 395                 400 
Thr Leu Asn Arg Thr
                405 


<210> 7812
<211> 517
<212> PRT
<213> Homo sapiens

<400> 7812
Met Ser Leu Gly Ser Glu Leu Phe Arg Asp Val Ala Ile Val Phe Ser
 1               5                  10                  15      
Gln Glu Glu Trp Gln Trp Leu Ala Pro Ala Gln Arg Asp Leu Tyr Arg
            20                  25                  30          
Asp Val Met Leu Glu Thr Tyr Ser Asn Leu Val Ser Leu Gly Leu Ala
        35                  40                  45              
Val Ser Lys Pro Asp Val Ile Ser Phe Leu Glu Gln Gly Lys Glu Pro
    50                  55                  60                  
Trp Met Val Glu Arg Val Val Ser Gly Gly Leu Cys Pro Val Leu Glu
65                  70                  75                  80  
Ser Arg Tyr Asp Thr Lys Glu Leu Phe Pro Lys Gln His Val Tyr Glu
                85                  90                  95      
Val Glu Ser Pro Gln Trp Glu Ile Met Glu Ser Leu Thr Ser Tyr Gly
            100                 105                 110         
Leu Glu Cys Ser Ser Phe Gln Asp Asp Trp Glu Cys Arg Asn Gln Phe
        115                 120                 125             
Asp Arg Gln Gln Gly Asn Pro Asp Arg His Phe His Gln Met Ile Ile
    130                 135                 140                 
Arg His Glu Glu Met Pro Thr Phe Asp Gln His Ala Ser Leu Thr Phe
145                 150                 155                 160 
Tyr Gln Lys Ile His Thr Arg Glu Lys Pro Phe Gly Tyr Asn Lys Cys
                165                 170                 175     
Arg Lys Asp Phe Trp Gln Lys Glu Leu Leu Ile Asn His Gln Gly Ile
            180                 185                 190         
Tyr Thr Asn Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe
        195                 200                 205             
Lys Tyr Gly Ser Arg Leu Ile Gln His Glu Asn Ile His Ser Gly Lys
    210                 215                 220                 
Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Asn Ser Gly Ser
225                 230                 235                 240 
Asn Phe Ile Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu
                245                 250                 255     
Cys Lys Asp Cys Glu Lys Ala Phe Ser Arg Ser Ser Gln Leu Ile Glu
            260                 265                 270         
His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Glu Cys
        275                 280                 285             
Gly Lys Ala Phe Asn Arg Ile Ser His Leu Lys Val His Tyr Arg Ile
    290                 295                 300                 
His Thr Gly Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Thr Phe
305                 310                 315                 320 
Ser His Arg Ser Gln Leu Ile Gln His Gln Thr Val His Thr Gly Arg
                325                 330                 335     
Lys Leu Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Asn Gln Gly Ser
            340                 345                 350         
Thr Leu Ile Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu
        355                 360                 365             
Cys Lys Val Cys Gly Lys Ala Phe Arg Val Ser Ser Gln Leu Lys Gln
    370                 375                 380                 
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Val Cys
385                 390                 395                 400 
Gly Arg Ala Phe Lys Arg Val Ser His Leu Thr Val His Tyr Arg Ile
                405                 410                 415     
His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe
            420                 425                 430         
Ser His Cys Ser Gln Leu Ile His His Gln Val Ile His Thr Glu Lys
        435                 440                 445             
Lys Pro Tyr Glu Tyr Lys Glu Cys Glu Lys Thr Leu Ser His Asp Ser
    450                 455                 460                 
Thr Thr Val Gln Pro Gln Arg Met His Asn Arg Glu Thr His Val Asn
465                 470                 475                 480 
Ile Ile Asn Val Glu Lys Pro Ser Ile Ser Ser Tyr Pro Leu Leu Ile
                485                 490                 495     
Ile Arg Glu Phe Met Leu Ala Ser Asn His Met Asn Gly Ser Asn Gly
            500                 505                 510         
Glu Ser Pro Leu Ala
        515         


<210> 7813
<211> 729
<212> PRT
<213> Homo sapiens

<400> 7813
Met Asn Lys Gly Trp Leu Glu Leu Glu Ser Asp Pro Gly Leu Phe Thr
 1               5                  10                  15      
Leu Leu Val Glu Asp Phe Gly Val Lys Gly Val Gln Val Glu Glu Ile
            20                  25                  30          
Tyr Asp Leu Gln Ser Lys Cys Gln Gly Pro Val Tyr Gly Phe Ile Phe
        35                  40                  45              
Leu Phe Lys Trp Ile Glu Glu Arg Arg Ser Arg Arg Lys Val Ser Thr
    50                  55                  60                  
Leu Val Asp Asp Thr Ser Val Ile Asp Asp Asp Ile Val Asn Asn Met
65                  70                  75                  80  
Phe Phe Ala His Gln Leu Ile Pro Asn Ser Cys Ala Thr His Ala Leu
                85                  90                  95      
Leu Ser Val Leu Leu Asn Cys Ser Ser Val Asp Leu Gly Pro Thr Leu
            100                 105                 110         
Ser Arg Met Lys Asp Phe Thr Lys Gly Phe Ser Pro Glu Ser Lys Gly
        115                 120                 125             
Tyr Ala Ile Gly Asn Ala Pro Glu Leu Ala Lys Ala His Asn Ser His
    130                 135                 140                 
Ala Arg Pro Glu Pro Arg His Leu Pro Glu Lys Gln Asn Gly Leu Ser
145                 150                 155                 160 
Ala Val Arg Thr Met Glu Ala Phe His Phe Val Ser Tyr Val Pro Ile
                165                 170                 175     
Thr Gly Arg Leu Phe Glu Leu Asp Gly Leu Lys Val Tyr Pro Ile Asp
            180                 185                 190         
His Gly Pro Trp Gly Glu Asp Glu Glu Trp Thr Asp Lys Ala Arg Arg
        195                 200                 205             
Val Ile Met Glu Arg Ile Gly Leu Ala Thr Ala Gly Glu Pro Tyr His
    210                 215                 220                 
Asp Ile Arg Phe Asn Leu Met Ala Val Val Pro Asp Arg Arg Ile Lys
225                 230                 235                 240 
Tyr Glu Ala Arg Leu His Val Leu Lys Val Asn Arg Gln Thr Val Leu
                245                 250                 255     
Glu Ala Leu Gln Gln Leu Ile Arg Val Thr Gln Pro Glu Leu Ile Gln
            260                 265                 270         
Thr His Lys Ser Gln Glu Ser Gln Leu Pro Glu Glu Ser Lys Ser Ala
        275                 280                 285             
Ser Asn Lys Ser Pro Leu Val Leu Glu Ala Asn Arg Ala Pro Ala Ala
    290                 295                 300                 
Ser Glu Gly Asn His Thr Asp Gly Ala Glu Glu Ala Ala Gly Ser Cys
305                 310                 315                 320 
Ala Gln Ala Pro Ser His Ser Pro Pro Asn Lys Pro Lys Leu Val Val
                325                 330                 335     
Lys Pro Pro Gly Ser Ser Leu Asn Gly Val His Pro Asn Pro Thr Pro
            340                 345                 350         
Ile Val Gln Arg Leu Pro Ala Phe Leu Asp Asn His Asn Tyr Ala Lys
        355                 360                 365             
Ser Pro Met Gln Glu Glu Glu Asp Leu Ala Ala Gly Val Gly Arg Ser
    370                 375                 380                 
Arg Val Pro Val Arg Pro Pro Gln Gln Tyr Ser Asp Asp Glu Asp Asp
385                 390                 395                 400 
Tyr Glu Asp Asp Glu Glu Asp Asp Val Gln Asn Thr Asn Ser Ala Leu
                405                 410                 415     
Arg Tyr Lys Gly Lys Gly Thr Gly Lys Pro Gly Ala Leu Ser Gly Ser
            420                 425                 430         
Ala Asp Gly Gln Leu Ser Val Leu Gln Pro Asn Thr Ile Asn Val Leu
        435                 440                 445             
Ala Glu Lys Leu Lys Glu Ser Gln Lys Asp Leu Ser Ile Pro Leu Ser
    450                 455                 460                 
Ile Lys Thr Ser Ser Gly Ala Gly Ser Pro Ala Val Ala Val Pro Thr
465                 470                 475                 480 
His Ser Gln Pro Ser Pro Thr Pro Ser Asn Glu Ser Thr Asp Thr Ala
                485                 490                 495     
Ser Glu Ile Gly Ser Ala Phe Asn Ser Pro Leu Arg Ser Pro Ile Arg
            500                 505                 510         
Ser Ala Asn Pro Thr Arg Pro Ser Ser Pro Val Thr Ser His Ile Ser
        515                 520                 525             
Lys Val Leu Phe Gly Glu Asp Asp Ser Leu Leu Arg Val Asp Cys Ile
    530                 535                 540                 
Arg Tyr Asn Arg Ala Val Arg Asp Leu Gly Pro Val Ile Ser Thr Gly
545                 550                 555                 560 
Leu Leu His Leu Ala Glu Asp Gly Val Leu Ser Pro Leu Ala Leu Thr
                565                 570                 575     
Glu Gly Gly Lys Gly Ser Ser Pro Ser Ile Arg Pro Ile Gln Gly Ser
            580                 585                 590         
Gln Gly Ser Ser Ser Pro Val Glu Lys Glu Val Val Glu Ala Thr Asp
        595                 600                 605             
Ser Arg Glu Lys Thr Gly Met Val Arg Pro Gly Glu Pro Leu Ser Gly
    610                 615                 620                 
Glu Lys Tyr Ser Pro Lys Glu Leu Leu Ala Leu Leu Lys Cys Val Glu
625                 630                 635                 640 
Ala Glu Ile Ala Asn Tyr Glu Ala Cys Leu Lys Glu Glu Val Glu Lys
                645                 650                 655     
Arg Lys Lys Phe Lys Ile Asp Asp Gln Arg Arg Thr His Asn Tyr Asp
            660                 665                 670         
Glu Phe Ile Cys Thr Phe Ile Ser Met Leu Ala Gln Glu Gly Met Leu
        675                 680                 685             
Ala Asn Leu Val Glu Gln Asn Ile Ser Val Arg Arg Arg Gln Gly Val
    690                 695                 700                 
Ser Ile Gly Arg Leu His Lys Gln Arg Lys Pro Asp Arg Arg Lys Arg
705                 710                 715                 720 
Ser Arg Pro Tyr Lys Ala Lys Arg Gln
                725                 


<210> 7814
<211> 1490
<212> PRT
<213> Homo sapiens

<400> 7814
Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly
 1               5                  10                  15      
Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser
            20                  25                  30          
Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys
        35                  40                  45              
His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly
    50                  55                  60                  
Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser
65                  70                  75                  80  
Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn
                85                  90                  95      
Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg
            100                 105                 110         
His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr
        115                 120                 125             
Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys
    130                 135                 140                 
Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp
145                 150                 155                 160 
Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser
                165                 170                 175     
Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser
            180                 185                 190         
Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys
        195                 200                 205             
Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His
    210                 215                 220                 
Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala
225                 230                 235                 240 
Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser
                245                 250                 255     
Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg
            260                 265                 270         
Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser
        275                 280                 285             
Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro
    290                 295                 300                 
Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser
305                 310                 315                 320 
Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe
                325                 330                 335     
Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser
            340                 345                 350         
Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser
        355                 360                 365             
His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile
    370                 375                 380                 
Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser
385                 390                 395                 400 
Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp
                405                 410                 415     
Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn
            420                 425                 430         
Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro
        435                 440                 445             
Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn
    450                 455                 460                 
Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys
465                 470                 475                 480 
Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys
                485                 490                 495     
Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile
            500                 505                 510         
Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro
        515                 520                 525             
Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro
    530                 535                 540                 
Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu
545                 550                 555                 560 
Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val
                565                 570                 575     
Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr
            580                 585                 590         
Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser
        595                 600                 605             
Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr
    610                 615                 620                 
Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Gly Asp
625                 630                 635                 640 
Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys
                645                 650                 655     
Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro
            660                 665                 670         
Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro
        675                 680                 685             
Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile
    690                 695                 700                 
Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly
705                 710                 715                 720 
Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly
                725                 730                 735     
Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp Thr Gly Glu Leu
            740                 745                 750         
Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro
        755                 760                 765             
Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg
    770                 775                 780                 
Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu
785                 790                 795                 800 
Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met
                805                 810                 815     
Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser
            820                 825                 830         
Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu
        835                 840                 845             
Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn
    850                 855                 860                 
Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu
865                 870                 875                 880 
Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val
                885                 890                 895     
Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg
            900                 905                 910         
Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu
        915                 920                 925             
Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln
    930                 935                 940                 
Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp
945                 950                 955                 960 
Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys
                965                 970                 975     
Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala
            980                 985                 990         
Ala Leu Asp Leu Leu Asp His Met Leu Thr Leu Asp Pro Ser Lys Arg
        995                 1000                1005            
Cys Thr Ala Glu Gln Thr Leu Gln Ser Asp Phe Leu Lys Asp Val Glu
    1010                1015                1020                
Leu Ser Lys Met Ala Pro Pro Asp Leu Pro His Trp Gln Asp Cys His
1025                1030                1035                1040
Glu Leu Trp Ser Lys Lys Arg Arg Arg Gln Arg Gln Ser Gly Val Val
                1045                1050                1055    
Val Glu Glu Pro Pro Pro Ser Lys Thr Ser Arg Lys Glu Thr Thr Ser
            1060                1065                1070        
Gly Thr Ser Thr Glu Pro Val Lys Asn Ser Ser Pro Ala Pro Pro Gln
        1075                1080                1085            
Pro Ala Pro Gly Lys Val Glu Ser Gly Ala Gly Asp Ala Ile Gly Leu
    1090                1095                1100                
Ala Asp Ile Thr Gln Gln Leu Asn Gln Ser Glu Leu Ala Val Leu Leu
1105                1110                1115                1120
Asn Leu Leu Gln Ser Gln Thr Asp Leu Ser Ile Pro Gln Met Ala Gln
                1125                1130                1135    
Leu Leu Asn Ile His Ser Asn Pro Glu Met Gln Gln Gln Leu Glu Ala
            1140                1145                1150        
Leu Asn Gln Ser Ile Ser Ala Leu Thr Glu Ala Thr Ser Gln Gln Gln
        1155                1160                1165            
Asp Ser Glu Thr Met Ala Pro Glu Glu Ser Leu Lys Glu Ala Pro Ser
    1170                1175                1180                
Ala Pro Val Ile Leu Pro Ser Ala Glu Gln Met Thr Leu Glu Ala Ser
1185                1190                1195                1200
Ser Thr Pro Ala Asp Met Gln Asn Ile Leu Ala Val Leu Leu Ser Gln
                1205                1210                1215    
Leu Met Lys Thr Gln Glu Pro Ala Gly Ser Leu Glu Glu Asn Asn Ser
            1220                1225                1230        
Asp Lys Asn Ser Gly Pro Gln Gly Pro Arg Arg Thr Pro Thr Met Pro
        1235                1240                1245            
Gln Glu Glu Ala Ala Ala Cys Pro Pro His Ile Leu Pro Pro Glu Lys
    1250                1255                1260                
Arg Pro Pro Glu Pro Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Pro
1265                1270                1275                1280
Leu Val Glu Gly Asp Leu Ser Ser Ala Pro Gln Glu Leu Asn Pro Ala
                1285                1290                1295    
Val Thr Ala Ala Leu Leu Gln Leu Leu Ser Gln Pro Glu Ala Glu Pro
            1300                1305                1310        
Pro Gly His Leu Pro His Glu His Gln Ala Leu Arg Pro Met Glu Tyr
        1315                1320                1325            
Ser Thr Arg Pro Arg Pro Asn Arg Thr Tyr Gly Asn Thr Asp Gly Pro
    1330                1335                1340                
Glu Thr Gly Phe Ser Ala Ile Asp Thr Asp Glu Arg Asn Ser Gly Pro
1345                1350                1355                1360
Ala Leu Thr Glu Ser Leu Val Gln Thr Leu Val Lys Asn Arg Thr Phe
                1365                1370                1375    
Ser Gly Ser Leu Ser His Leu Gly Glu Ser Ser Ser Tyr Gln Gly Thr
            1380                1385                1390        
Gly Ser Val Gln Phe Pro Gly Asp Gln Asp Leu Arg Phe Ala Arg Val
        1395                1400                1405            
Pro Leu Ala Leu His Pro Val Val Gly Gln Pro Phe Leu Lys Ala Glu
    1410                1415                1420                
Gly Ser Ser Asn Ser Val Val His Ala Glu Thr Lys Leu Gln Asn Tyr
1425                1430                1435                1440
Gly Glu Leu Gly Pro Gly Thr Thr Gly Ala Ser Ser Ser Gly Ala Gly
                1445                1450                1455    
Leu His Trp Gly Gly Pro Thr Gln Ser Ser Ala Tyr Gly Lys Leu Tyr
            1460                1465                1470        
Arg Gly Pro Thr Arg Val Pro Pro Arg Gly Gly Arg Gly Arg Gly Val
        1475                1480                1485            
Pro Tyr
    1490


<210> 7815
<211> 2677
<212> PRT
<213> Homo sapiens

<400> 7815
Met Ser Thr Cys Cys Trp Cys Thr Pro Gly Gly Ala Ser Thr Ile Asp
 1               5                  10                  15      
Phe Leu Lys Arg Tyr Ala Ser Asn Thr Pro Ser Gly Glu Phe Gln Thr
            20                  25                  30          
Ala Asp Glu Asp Leu Cys Tyr Cys Leu Glu Cys Val Ala Glu Tyr His
        35                  40                  45              
Lys Ala Arg Asp Glu Leu Pro Phe Leu His Glu Val Leu Trp Glu Leu
    50                  55                  60                  
Glu Thr Leu Arg Leu Ile Asn His Phe Glu Lys Ser Met Lys Ala Glu
65                  70                  75                  80  
Ile Gly Asp Asp Asp Glu Leu Tyr Ile Val Asp Asn Asn Gly Glu Met
                85                  90                  95      
Pro Leu Phe Asp Ile Thr Gly Gln Asp Phe Glu Asn Lys Leu Arg Val
            100                 105                 110         
Pro Leu Leu Glu Ile Leu Lys Tyr Pro Tyr Leu Leu Leu His Glu Arg
        115                 120                 125             
Val Asn Glu Leu Cys Val Glu Ala Leu Cys Arg Met Glu Gln Ala Asn
    130                 135                 140                 
Cys Ser Phe Gln Val Phe Asp Lys His Pro Gly Ile Tyr Leu Phe Leu
145                 150                 155                 160 
Val His Pro Asn Glu Met Val Arg Arg Trp Ala Ile Leu Thr Ala Arg
                165                 170                 175     
Asn Leu Gly Lys Val Asp Arg Asp Asp Tyr Tyr Asp Leu Gln Glu Val
            180                 185                 190         
Leu Leu Cys Leu Phe Lys Val Ile Glu Leu Gly Leu Leu Glu Ser Pro
        195                 200                 205             
Asp Ile Tyr Thr Ser Ser Val Leu Glu Lys Gly Lys Leu Ile Leu Leu
    210                 215                 220                 
Pro Ser His Met Tyr Asp Thr Thr Asn Tyr Lys Ser Tyr Trp Leu Gly
225                 230                 235                 240 
Ile Cys Met Leu Leu Thr Ile Leu Glu Glu Gln Ala Met Asp Ser Leu
                245                 250                 255     
Leu Leu Gly Ser Asp Lys Gln Asn Asp Phe Met Gln Ser Ile Leu His
            260                 265                 270         
Thr Met Glu Arg Glu Ala Asp Asp Asp Ser Val Asp Pro Phe Trp Pro
        275                 280                 285             
Ala Leu His Cys Phe Met Val Ile Leu Asp Arg Leu Gly Ser Lys Val
    290                 295                 300                 
Trp Gly Gln Leu Met Asp Pro Ile Val Ala Phe Gln Thr Ile Ile Asn
305                 310                 315                 320 
Asn Ala Ser Tyr Asn Arg Glu Ile Arg His Ile Arg Asn Ser Ser Val
                325                 330                 335     
Arg Thr Lys Leu Glu Pro Glu Ser Tyr Leu Asp Asp Met Val Thr Cys
            340                 345                 350         
Ser Gln Ile Val Tyr Asn Tyr Asn Pro Glu Lys Thr Lys Lys Asp Ser
        355                 360                 365             
Gly Trp Arg Thr Ala Ile Cys Pro Asp Tyr Cys Pro Asn Met Tyr Glu
    370                 375                 380                 
Glu Met Glu Thr Leu Ala Ser Val Leu Gln Ser Asp Ile Gly Gln Asp
385                 390                 395                 400 
Met Arg Val His Asn Ser Thr Phe Leu Trp Phe Ile Pro Phe Val Gln
                405                 410                 415     
Ser Leu Met Asp Leu Lys Asp Leu Gly Val Ala Tyr Ile Ala Gln Val
            420                 425                 430         
Val Asn His Leu Tyr Ser Glu Val Lys Glu Val Leu Asn Gln Thr Asp
        435                 440                 445             
Ala Val Cys Asp Lys Val Thr Glu Phe Phe Leu Leu Ile Leu Val Ser
    450                 455                 460                 
Val Ile Glu Leu His Arg Asn Lys Lys Cys Leu His Leu Leu Trp Val
465                 470                 475                 480 
Ser Ser Gln Gln Trp Val Glu Ala Val Val Lys Cys Ala Lys Leu Pro
                485                 490                 495     
Thr Thr Ala Phe Thr Arg Ser Ser Glu Lys Ser Ser Gly Asn Cys Ser
            500                 505                 510         
Lys Gly Thr Ala Met Ile Ser Ser Leu Ser Leu His Ser Met Pro Ser
        515                 520                 525             
Asn Ser Val Gln Leu Ala Tyr Val Gln Leu Ile Arg Ser Leu Leu Lys
    530                 535                 540                 
Glu Gly Tyr Gln Leu Gly Gln Gln Ser Leu Cys Lys Arg Phe Trp Asp
545                 550                 555                 560 
Lys Leu Asn Leu Phe Leu Arg Gly Asn Leu Ser Leu Gly Trp Gln Leu
                565                 570                 575     
Thr Ser Gln Glu Thr His Glu Leu Gln Ser Cys Leu Lys Gln Ile Ile
            580                 585                 590         
Arg Asn Ile Lys Phe Lys Ala Pro Pro Cys Asn Thr Phe Val Asp Leu
        595                 600                 605             
Thr Ser Ala Cys Lys Ile Ser Pro Ala Ser Tyr Asn Lys Glu Glu Ser
    610                 615                 620                 
Glu Gln Met Gly Lys Thr Ser Arg Lys Asp Met His Cys Leu Glu Ala
625                 630                 635                 640 
Ser Ser Pro Thr Phe Ser Lys Glu Pro Met Lys Val Gln Asp Ser Val
                645                 650                 655     
Ser Ile Lys Ala Asp Asn Thr Ile Glu Gly Asp Asn Asn Glu Gln Asn
            660                 665                 670         
Tyr Ile Lys Asp Val Lys Leu Glu Asp His Leu Leu Ala Gly Ser Cys
        675                 680                 685             
Leu Lys Gln Ser Ser Lys Asn Ile Phe Thr Glu Arg Ala Glu Asp Gln
    690                 695                 700                 
Ile Lys Ile Ser Thr Arg Lys Gln Lys Ser Val Lys Glu Ile Ser Ser
705                 710                 715                 720 
Tyr Thr Pro Lys Asp Cys Thr Ser Arg Asn Gly Pro Glu Arg Gly Cys
                725                 730                 735     
Asp Arg Gly Ile Ile Val Ser Thr Arg Leu Leu Thr Asp Ser Ser Thr
            740                 745                 750         
Asp Ala Leu Glu Lys Val Ser Thr Ser Asn Glu Asp Phe Ser Leu Lys
        755                 760                 765             
Asp Asp Ala Leu Ala Lys Thr Ser Lys Arg Lys Thr Lys Val Gln Lys
    770                 775                 780                 
Asp Glu Ile Cys Ala Lys Leu Ser His Val Ile Lys Lys Gln His Arg
785                 790                 795                 800 
Lys Ser Thr Leu Val Asp Asn Thr Ile Asn Leu Asp Glu Asn Leu Thr
                805                 810                 815     
Val Ser Asn Ile Glu Ser Phe Tyr Ser Arg Lys Asp Thr Gly Val Gln
            820                 825                 830         
Lys Gly Asp Gly Phe Ile His Asn Leu Ser Leu Asp Pro Ser Gly Val
        835                 840                 845             
Leu Asp Asp Lys Asn Gly Glu Gln Lys Ser Gln Asn Asn Val Leu Pro
    850                 855                 860                 
Lys Glu Lys Gln Leu Lys Asn Glu Glu Leu Val Ile Phe Ser Phe His
865                 870                 875                 880 
Glu Asn Asn Cys Lys Ile Gln Glu Phe His Val Asp Gly Lys Glu Leu
                885                 890                 895     
Ile Pro Phe Thr Glu Met Thr Asn Ala Ser Glu Lys Lys Ser Ser Pro
            900                 905                 910         
Phe Lys Asp Leu Met Thr Val Pro Glu Ser Arg Asp Glu Glu Met Ser
        915                 920                 925             
Asn Ser Thr Ser Val Ile Tyr Ser Asn Leu Thr Arg Glu Gln Ala Pro
    930                 935                 940                 
Asp Ile Ser Pro Lys Ser Asp Thr Leu Thr Asp Ser Gln Ile Asp Arg
945                 950                 955                 960 
Asp Leu His Lys Leu Ser Leu Leu Ala Gln Ala Ser Val Ile Thr Phe
                965                 970                 975     
Pro Ser Asp Ser Pro Gln Asn Ser Ser Gln Leu Gln Arg Lys Val Lys
            980                 985                 990         
Glu Asp Lys Arg Cys Phe Thr Ala Asn Gln Asn Asn Val Gly Asp Thr
        995                 1000                1005            
Ser Arg Gly Gln Val Ile Ile Ile Ser Asp Ser Asp Asp Asp Asp Asp
    1010                1015                1020                
Glu Arg Ile Leu Ser Leu Glu Lys Leu Thr Lys Gln Asp Lys Ile Cys
1025                1030                1035                1040
Leu Glu Arg Glu His Pro Glu Gln His Val Ser Thr Val Asn Ser Lys
                1045                1050                1055    
Glu Glu Lys Asn Pro Val Lys Glu Glu Lys Thr Glu Thr Leu Phe Gln
            1060                1065                1070        
Phe Glu Glu Ser Asp Ser Gln Cys Phe Glu Phe Glu Ser Ser Ser Glu
        1075                1080                1085            
Val Phe Ser Val Trp Gln Asp His Pro Asp Asp Asn Asn Ser Val Gln
    1090                1095                1100                
Asp Gly Glu Lys Lys Cys Leu Ala Pro Ile Ala Asn Thr Thr Asn Gly
1105                1110                1115                1120
Gln Gly Cys Thr Asp Tyr Val Ser Glu Val Val Lys Lys Gly Ala Glu
                1125                1130                1135    
Gly Ile Glu Glu His Thr Arg Pro Arg Ser Ile Ser Val Glu Glu Phe
            1140                1145                1150        
Cys Glu Ile Glu Val Lys Lys Pro Lys Arg Lys Arg Ser Glu Lys Pro
        1155                1160                1165            
Met Ala Glu Asp Pro Val Arg Pro Ser Ser Ser Val Arg Asn Glu Gly
    1170                1175                1180                
Gln Ser Asp Thr Asn Lys Arg Glu Leu Val Gly Asn Asp Phe Lys Ser
1185                1190                1195                1200
Ile Asp Arg Arg Thr Ser Thr Pro Asn Ser Arg Ile Gln Arg Ala Thr
                1205                1210                1215    
Thr Val Ser Gln Lys Lys Ser Ser Lys Leu Cys Thr Cys Thr Glu Pro
            1220                1225                1230        
Ile Arg Lys Val Pro Val Ser Lys Thr Pro Lys Lys Thr His Ser Asp
        1235                1240                1245            
Ala Lys Lys Arg Gln Asn Arg Ser Ser Asn Tyr Leu Ser Cys Arg Thr
    1250                1255                1260                
Thr Pro Ala Ile Val Pro Pro Lys Lys Phe Arg Gln Cys Pro Glu Pro
1265                1270                1275                1280
Thr Ser Thr Ala Glu Lys Leu Gly Leu Lys Lys Gly Pro Arg Lys Ala
                1285                1290                1295    
Tyr Glu Leu Ser Gln Arg Ser Leu Asp Tyr Val Ala Gln Leu Arg Asp
            1300                1305                1310        
His Gly Lys Thr Val Gly Val Val Asp Thr Arg Lys Lys Thr Lys Leu
        1315                1320                1325            
Ile Ser Pro Gln Asn Leu Ser Val Arg Asn Asn Lys Lys Leu Leu Thr
    1330                1335                1340                
Ser Gln Glu Leu Gln Met Gln Arg Gln Ile Arg Pro Lys Ser Gln Lys
1345                1350                1355                1360
Asn Arg Arg Arg Leu Ser Asp Cys Glu Ser Thr Asp Val Lys Arg Ala
                1365                1370                1375    
Gly Ser His Thr Ala Gln Asn Ser Asp Val Phe Val Pro Glu Ser Asp
            1380                1385                1390        
Arg Ser Asp Tyr Asn Cys Thr Gly Gly Thr Glu Val Leu Ala Asn Ser
        1395                1400                1405            
Asn Arg Lys Gln Leu Ile Lys Cys Met Pro Ser Glu Pro Glu Thr Ile
    1410                1415                1420                
Lys Ala Lys His Gly Ser Pro Ala Thr Asp Asp Ala Cys Pro Leu Asn
1425                1430                1435                1440
Gln Cys Asp Ser Val Val Leu Asn Gly Thr Val Pro Thr Asn Glu Val
                1445                1450                1455    
Ile Val Ser Thr Ser Glu Asp Pro Leu Gly Gly Gly Asp Pro Thr Ala
            1460                1465                1470        
Arg His Ile Glu Met Ala Ala Leu Lys Glu Gly Glu Pro Asp Ser Ser
        1475                1480                1485            
Ser Asp Ala Glu Glu Asp Asn Leu Phe Leu Thr Gln Asn Asp Pro Glu
    1490                1495                1500                
Asp Met Asp Leu Cys Ser Gln Met Glu Asn Asp Asn Tyr Lys Leu Ile
1505                1510                1515                1520
Glu Leu Ile His Gly Lys Asp Thr Val Glu Val Glu Glu Asp Ser Val
                1525                1530                1535    
Ser Arg Pro Gln Leu Glu Ser Leu Ser Gly Thr Lys Cys Lys Tyr Lys
            1540                1545                1550        
Asp Cys Leu Glu Thr Thr Lys Asn Gln Gly Glu Tyr Cys Pro Lys His
        1555                1560                1565            
Ser Glu Val Lys Ala Ala Asp Glu Asp Val Phe Arg Lys Pro Gly Leu
    1570                1575                1580                
Pro Pro Pro Ala Ser Lys Pro Leu Arg Pro Thr Thr Lys Ile Phe Ser
1585                1590                1595                1600
Ser Lys Ser Thr Ser Arg Ile Ala Gly Leu Ser Lys Ser Leu Glu Thr
                1605                1610                1615    
Ser Ser Ala Leu Ser Pro Ser Leu Lys Asn Lys Ser Lys Gly Ile Gln
            1620                1625                1630        
Ser Ile Leu Lys Val Pro Gln Pro Val Pro Leu Ile Ala Gln Lys Pro
        1635                1640                1645            
Val Gly Glu Met Lys Asn Ser Cys Asn Val Leu His Pro Gln Ser Pro
    1650                1655                1660                
Asn Asn Ser Asn Arg Gln Gly Cys Lys Val Pro Phe Gly Glu Ser Lys
1665                1670                1675                1680
Tyr Phe Pro Ser Ser Ser Pro Val Asn Ile Leu Leu Ser Ser Gln Ser
                1685                1690                1695    
Val Ser Asp Thr Phe Val Lys Glu Val Leu Lys Trp Lys Tyr Glu Met
            1700                1705                1710        
Phe Leu Asn Phe Gly Gln Cys Gly Pro Pro Ala Ser Leu Cys Gln Ser
        1715                1720                1725            
Ile Ser Arg Pro Val Pro Val Arg Phe His Asn Tyr Gly Asp Tyr Phe
    1730                1735                1740                
Asn Val Phe Phe Pro Leu Met Val Leu Asn Thr Phe Glu Thr Val Ala
1745                1750                1755                1760
Gln Glu Trp Leu Asn Ser Pro Asn Arg Glu Asn Phe Tyr Gln Leu Gln
                1765                1770                1775    
Val Arg Lys Phe Pro Ala Asp Tyr Ile Lys Tyr Trp Glu Phe Ala Val
            1780                1785                1790        
Tyr Leu Glu Glu Cys Glu Leu Ala Lys Gln Leu Tyr Pro Lys Glu Asn
        1795                1800                1805            
Asp Leu Val Phe Leu Ala Pro Glu Arg Ile Asn Glu Glu Lys Lys Asp
    1810                1815                1820                
Thr Lys Arg Asn Asp Ile Gln Asp Leu His Glu Tyr His Ser Gly Tyr
1825                1830                1835                1840
Val His Lys Phe Arg Arg Thr Ser Val Met Arg Asn Gly Lys Thr Glu
                1845                1850                1855    
Cys Tyr Leu Ser Ile Gln Thr Gln Glu Asn Phe Pro Ala Asn Leu Asn
            1860                1865                1870        
Glu Leu Val Asn Cys Ile Val Ile Ser Ser Leu Val Thr Thr Gln Arg
        1875                1880                1885            
Lys Leu Lys Ala Met Ser Leu Leu Gly Ser Arg Asn Gln Leu Ala Arg
    1890                1895                1900                
Ala Val Leu Asn Pro Asn Pro Met Asp Phe Cys Thr Lys Asp Leu Leu
1905                1910                1915                1920
Thr Thr Thr Ser Glu Arg Ile Ile Ala Tyr Leu Arg Asp Phe Asn Glu
                1925                1930                1935    
Asp Gln Lys Lys Ala Ile Glu Thr Ala Tyr Ala Met Val Lys His Ser
            1940                1945                1950        
Pro Ser Val Ala Lys Ile Cys Leu Ile His Gly Pro Pro Gly Thr Gly
        1955                1960                1965            
Lys Ser Lys Thr Ile Val Gly Leu Leu Tyr Arg Leu Leu Thr Glu Asn
    1970                1975                1980                
Gln Arg Lys Gly His Ser Asp Glu Asn Ser Asn Ala Lys Ile Lys Gln
1985                1990                1995                2000
Asn Arg Val Leu Val Cys Ala Pro Ser Asn Ala Ala Val Asp Glu Leu
                2005                2010                2015    
Met Lys Lys Ile Ile Leu Glu Phe Lys Glu Lys Cys Lys Asp Lys Lys
            2020                2025                2030        
Asn Pro Leu Gly Asn Cys Gly Asp Ile Asn Leu Val Arg Leu Gly Pro
        2035                2040                2045            
Glu Lys Ser Ile Asn Ser Glu Val Leu Lys Phe Ser Leu Asp Ser Gln
    2050                2055                2060                
Val Asn His Arg Met Lys Lys Glu Leu Pro Ser His Val Gln Ala Met
2065                2070                2075                2080
His Lys Arg Lys Glu Phe Leu Asp Tyr Gln Leu Asp Glu Leu Ser Arg
                2085                2090                2095    
Gln Arg Ala Leu Cys Arg Gly Gly Arg Glu Ile Gln Arg Gln Glu Leu
            2100                2105                2110        
Asp Glu Asn Ile Ser Lys Val Ser Lys Glu Arg Gln Glu Leu Ala Ser
        2115                2120                2125            
Lys Ile Lys Glu Val Gln Gly Arg Pro Gln Lys Thr Gln Ser Ile Ile
    2130                2135                2140                
Ile Leu Glu Ser His Ile Ile Cys Cys Thr Leu Ser Thr Ser Gly Gly
2145                2150                2155                2160
Leu Leu Leu Glu Ser Ala Phe Arg Gly Gln Gly Gly Val Pro Phe Ser
                2165                2170                2175    
Cys Val Ile Val Asp Glu Ala Gly Gln Ser Cys Glu Ile Glu Thr Leu
            2180                2185                2190        
Thr Pro Leu Ile His Arg Cys Asn Lys Leu Ile Leu Val Gly Asp Pro
        2195                2200                2205            
Lys Gln Leu Pro Pro Thr Val Ile Ser Met Lys Ala Gln Glu Tyr Gly
    2210                2215                2220                
Tyr Asp Gln Ser Met Met Ala Arg Phe Cys Arg Leu Leu Glu Glu Asn
2225                2230                2235                2240
Val Glu His Asn Met Ile Ser Arg Leu Pro Ile Leu Gln Leu Thr Val
                2245                2250                2255    
Gln Tyr Arg Met His Pro Asp Ile Cys Leu Phe Pro Ser Asn Tyr Val
            2260                2265                2270        
Tyr Asn Arg Asn Leu Lys Thr Asn Arg Gln Thr Glu Ala Ile Arg Cys
        2275                2280                2285            
Ser Ser Asp Trp Pro Phe Gln Pro Tyr Leu Val Phe Asp Val Gly Asp
    2290                2295                2300                
Gly Ser Glu Arg Arg Asp Asn Asp Ser Tyr Ile Asn Val Gln Glu Ile
2305                2310                2315                2320
Lys Leu Val Met Glu Ile Ile Lys Leu Ile Lys Asp Lys Arg Lys Asp
                2325                2330                2335    
Val Ser Phe Arg Asn Ile Gly Ile Ile Thr His Tyr Lys Ala Gln Lys
            2340                2345                2350        
Thr Met Ile Gln Lys Asp Leu Asp Lys Glu Phe Asp Arg Lys Gly Pro
        2355                2360                2365            
Ala Glu Val Asp Thr Val Asp Ala Phe Gln Gly Arg Gln Lys Asp Cys
    2370                2375                2380                
Val Ile Val Thr Cys Val Arg Ala Asn Ser Ile Gln Gly Ser Ile Gly
2385                2390                2395                2400
Phe Leu Ala Ser Leu Gln Arg Leu Asn Val Thr Ile Thr Arg Ala Lys
                2405                2410                2415    
Tyr Ser Leu Phe Ile Leu Gly His Leu Arg Thr Leu Met Glu Asn Gln
            2420                2425                2430        
His Trp Asn Gln Leu Ile Gln Asp Ala Gln Lys Arg Gly Ala Ile Ile
        2435                2440                2445            
Lys Thr Cys Asp Lys Asn Tyr Arg His Asp Ala Val Lys Ile Leu Lys
    2450                2455                2460                
Leu Lys Pro Val Leu Gln Arg Ser Leu Thr His Pro Pro Thr Ile Ala
2465                2470                2475                2480
Pro Glu Gly Ser Arg Pro Gln Gly Gly Leu Pro Ser Ser Lys Leu Asp
                2485                2490                2495    
Ser Gly Phe Ala Lys Thr Ser Val Ala Ala Ser Leu Tyr His Thr Pro
            2500                2505                2510        
Ser Asp Ser Lys Glu Ile Thr Leu Thr Val Thr Ser Lys Asp Pro Glu
        2515                2520                2525            
Arg Pro Pro Val His Asp Gln Leu Gln Asp Pro Arg Leu Leu Lys Arg
    2530                2535                2540                
Met Gly Ile Glu Val Lys Gly Gly Ile Phe Leu Trp Asp Pro Gln Pro
2545                2550                2555                2560
Ser Ser Pro Gln His Pro Gly Ala Thr Pro Pro Thr Gly Glu Pro Gly
                2565                2570                2575    
Phe Pro Val Val His Gln Asp Leu Ser His Ile Gln Gln Pro Ala Ala
            2580                2585                2590        
Val Val Ala Ala Leu Ser Ser His Lys Pro Pro Val Arg Gly Glu Pro
        2595                2600                2605            
Pro Ala Ala Ser Pro Glu Ala Ser Thr Cys Gln Ser Lys Cys Asp Asp
    2610                2615                2620                
Pro Glu Glu Glu Leu Cys His Arg Arg Glu Ala Arg Ala Phe Ser Glu
2625                2630                2635                2640
Gly Glu Gln Glu Lys Cys Gly Ser Glu Thr His His Thr Arg Arg Asn
                2645                2650                2655    
Ser Arg Trp Asp Lys Arg Thr Leu Glu Gln Glu Asp Ser Ser Ser Lys
            2660                2665                2670        
Lys Arg Lys Leu Leu
        2675        


<210> 7816
<211> 749
<212> PRT
<213> Homo sapiens

<400> 7816
Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr
 1               5                  10                  15      
Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys
            20                  25                  30          
Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu
        35                  40                  45              
Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn
    50                  55                  60                  
Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp
65                  70                  75                  80  
Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr
                85                  90                  95      
Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met
            100                 105                 110         
Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr
        115                 120                 125             
Glu Met Val Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu
    130                 135                 140                 
Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln
145                 150                 155                 160 
Arg Lys Glu His Ile Arg Glu Ser Met Lys Lys Leu Leu Gly Pro Lys
                165                 170                 175     
Asn Ser Glu Gly Leu His Ser Ala Arg Asp Val Pro Val Val Ala Ile
            180                 185                 190         
Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val
        195                 200                 205             
Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val
    210                 215                 220                 
Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His
225                 230                 235                 240 
Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met
                245                 250                 255     
Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val
            260                 265                 270         
Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro
        275                 280                 285             
Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile
    290                 295                 300                 
His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn
305                 310                 315                 320 
Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro
                325                 330                 335     
Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr
            340                 345                 350         
Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe
        355                 360                 365             
Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn
    370                 375                 380                 
Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu
385                 390                 395                 400 
Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser Arg Gly Ser Thr
                405                 410                 415     
Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His Ile Val Ser Asn
            420                 425                 430         
Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro Lys Gly Thr Glu
        435                 440                 445             
Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn Gln Ala Ser Trp
    450                 455                 460                 
Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn
465                 470                 475                 480 
Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu
                485                 490                 495     
Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser Asp Phe Ala Thr
            500                 505                 510         
Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro
        515                 520                 525             
Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys
    530                 535                 540                 
Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu
545                 550                 555                 560 
Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe
                565                 570                 575     
Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu
            580                 585                 590         
Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp
        595                 600                 605             
Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys
    610                 615                 620                 
Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr Ile Ile His Phe
625                 630                 635                 640 
Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro
                645                 650                 655     
Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp
            660                 665                 670         
Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln
        675                 680                 685             
Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn
    690                 695                 700                 
Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile Glu Tyr Arg Arg
705                 710                 715                 720 
Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg
                725                 730                 735     
Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys Ala
            740                 745                 


<210> 7817
<211> 1258
<212> PRT
<213> Homo sapiens

<400> 7817
Met Ile Thr Ser Glu Leu Pro Val Leu Gln Asp Ser Thr Asn Glu Thr
 1               5                  10                  15      
Thr Ala His Ser Asp Ala Gly Ser Glu Leu Glu Glu Thr Glu Val Lys
            20                  25                  30          
Gly Lys Arg Lys Arg Gly Arg Pro Gly Arg Pro Pro Ser Thr Asn Lys
        35                  40                  45              
Lys Pro Arg Lys Ser Pro Gly Glu Lys Ser Arg Ile Glu Ala Gly Ile
    50                  55                  60                  
Arg Gly Ala Gly Arg Gly Arg Ala Asn Gly His Pro Gln Gln Asn Gly
65                  70                  75                  80  
Glu Gly Glu Pro Val Thr Leu Phe Glu Val Val Lys Leu Gly Lys Ser
                85                  90                  95      
Ala Met Gln Ser Val Val Asp Asp Trp Ile Glu Ser Tyr Lys Gln Asp
            100                 105                 110         
Arg Asp Ile Ala Leu Leu Asp Leu Ile Asn Phe Phe Ile Gln Cys Ser
        115                 120                 125             
Gly Cys Arg Gly Thr Val Arg Ile Glu Met Phe Arg Asn Met Gln Asn
    130                 135                 140                 
Ala Glu Ile Ile Arg Lys Met Thr Glu Glu Phe Asp Glu Asp Ser Gly
145                 150                 155                 160 
Asp Tyr Pro Leu Thr Met Pro Gly Pro Gln Trp Lys Lys Phe Arg Ser
                165                 170                 175     
Asn Phe Cys Glu Phe Ile Gly Val Leu Ile Arg Gln Cys Gln Tyr Ser
            180                 185                 190         
Ile Ile Tyr Asp Glu Tyr Met Met Asp Thr Val Ile Ser Leu Leu Thr
        195                 200                 205             
Gly Leu Ser Asp Ser Gln Val Arg Ala Phe Arg His Thr Ser Thr Leu
    210                 215                 220                 
Ala Ala Met Lys Leu Met Thr Ala Leu Val Asn Val Ala Leu Asn Leu
225                 230                 235                 240 
Ser Ile His Gln Asp Asn Thr Gln Arg Gln Tyr Glu Ala Glu Arg Asn
                245                 250                 255     
Lys Met Ile Gly Lys Arg Ala Asn Glu Arg Leu Glu Leu Leu Leu Gln
            260                 265                 270         
Lys Arg Lys Glu Leu Gln Glu Asn Gln Asp Glu Ile Glu Asn Met Met
        275                 280                 285             
Asn Ser Ile Phe Lys Gly Ile Phe Val His Arg Tyr Arg Asp Ala Ile
    290                 295                 300                 
Ala Glu Ile Arg Ala Ile Cys Ile Glu Glu Ile Gly Val Trp Met Lys
305                 310                 315                 320 
Met Tyr Ser Asp Ala Phe Leu Asn Asp Ser Tyr Leu Lys Tyr Val Gly
                325                 330                 335     
Trp Thr Leu His Asp Arg Gln Gly Glu Val Arg Leu Lys Cys Leu Lys
            340                 345                 350         
Ala Leu Gln Ser Leu Tyr Thr Asn Arg Glu Leu Phe Pro Lys Leu Glu
        355                 360                 365             
Leu Phe Thr Asn Arg Phe Lys Asp Arg Ile Val Ser Met Thr Leu Asp
    370                 375                 380                 
Lys Glu Tyr Asp Val Ala Val Glu Ala Ile Arg Leu Val Thr Leu Ile
385                 390                 395                 400 
Leu His Gly Ser Glu Glu Ala Leu Ser Asn Glu Asp Cys Glu Asn Val
                405                 410                 415     
Tyr His Leu Val Tyr Ser Ala His Arg Pro Val Ala Val Ala Ala Gly
            420                 425                 430         
Glu Phe Leu His Lys Lys Leu Phe Ser Arg His Asp Pro Gln Ala Glu
        435                 440                 445             
Glu Ala Leu Ala Lys Arg Arg Gly Arg Asn Ser Pro Asn Gly Asn Leu
    450                 455                 460                 
Ile Arg Met Leu Val Leu Phe Phe Leu Glu Ser Glu Leu His Glu His
465                 470                 475                 480 
Ala Ala Tyr Leu Val Asp Ser Leu Trp Glu Ser Ser Gln Glu Leu Leu
                485                 490                 495     
Lys Asp Trp Glu Cys Met Thr Glu Leu Leu Leu Glu Glu Pro Val Gln
            500                 505                 510         
Gly Glu Glu Ala Met Ser Asp Arg Gln Glu Ser Ala Leu Ile Glu Leu
        515                 520                 525             
Met Val Cys Thr Ile Arg Gln Ala Ala Glu Ala His Pro Pro Val Gly
    530                 535                 540                 
Arg Gly Thr Gly Lys Arg Val Leu Thr Ala Lys Glu Arg Lys Thr Gln
545                 550                 555                 560 
Ile Asp Asp Arg Asn Lys Leu Thr Glu His Phe Ile Ile Thr Leu Pro
                565                 570                 575     
Met Leu Leu Ser Lys Tyr Ser Ala Asp Ala Glu Lys Val Ala Asn Leu
            580                 585                 590         
Leu Gln Ile Pro Gln Tyr Phe Asp Leu Glu Ile Tyr Ser Thr Gly Arg
        595                 600                 605             
Met Glu Lys His Leu Asp Ala Leu Leu Lys Gln Ile Lys Phe Val Val
    610                 615                 620                 
Glu Lys His Val Glu Ser Asp Val Leu Glu Ala Cys Ser Lys Thr Tyr
625                 630                 635                 640 
Ser Ile Leu Cys Asn Glu Glu Tyr Thr Ile Gln Asn Arg Val Asp Ile
                645                 650                 655     
Ala Arg Ser Gln Leu Ile Asp Glu Phe Val Asp Arg Phe Asn His Ser
            660                 665                 670         
Val Glu Asp Leu Leu Gln Glu Gly Glu Glu Ala Asp Asp Asp Asp Ile
        675                 680                 685             
Tyr Asn Val Leu Ser Thr Leu Lys Arg Leu Thr Ser Phe Gln Asn Ala
    690                 695                 700                 
His Asp Leu Thr Lys Trp Asp Leu Phe Gly Asn Cys Tyr Arg Leu Leu
705                 710                 715                 720 
Lys Thr Gly Ile Glu His Gly Ala Met Pro Glu Gln Ile Val Val Gln
                725                 730                 735     
Ala Leu Gln Cys Ser His Tyr Ser Ile Leu Trp Gln Leu Val Lys Ile
            740                 745                 750         
Thr Asp Gly Ser Pro Ser Lys Glu Asp Leu Leu Val Leu Arg Lys Thr
        755                 760                 765             
Val Lys Ser Phe Leu Ala Val Cys Gln Gln Cys Leu Ser Asn Val Asn
    770                 775                 780                 
Thr Pro Val Lys Glu Gln Ala Phe Met Leu Leu Cys Asp Leu Leu Met
785                 790                 795                 800 
Ile Phe Ser His Gln Leu Met Thr Gly Gly Arg Glu Gly Leu Gln Pro
                805                 810                 815     
Leu Val Phe Asn Pro Asp Thr Gly Leu Gln Ser Glu Leu Leu Ser Phe
            820                 825                 830         
Val Met Asp His Val Phe Ile Asp Gln Asp Glu Glu Asn Gln Ser Met
        835                 840                 845             
Glu Gly Asp Glu Glu Asp Glu Ala Asn Lys Ile Glu Ala Leu His Lys
    850                 855                 860                 
Arg Arg Asn Leu Leu Ala Ala Phe Ser Lys Leu Ile Ile Tyr Asp Ile
865                 870                 875                 880 
Val Asp Met His Ala Ala Ala Asp Ile Phe Lys His Tyr Met Lys Tyr
                885                 890                 895     
Tyr Asn Asp Tyr Gly Asp Ile Ile Lys Glu Thr Leu Ser Lys Thr Arg
            900                 905                 910         
Gln Ile Asp Lys Ile Gln Cys Ala Lys Thr Leu Ile Leu Ser Leu Gln
        915                 920                 925             
Gln Leu Phe Asn Glu Leu Val Gln Glu Gln Gly Pro Asn Leu Asp Arg
    930                 935                 940                 
Thr Ser Ala His Val Ser Gly Ile Lys Glu Leu Ala Arg Arg Phe Ala
945                 950                 955                 960 
Leu Thr Phe Gly Leu Asp Gln Ile Lys Thr Arg Glu Ala Val Ala Thr
                965                 970                 975     
Leu His Lys Asp Gly Ile Glu Phe Ala Phe Lys Tyr Gln Asn Gln Lys
            980                 985                 990         
Gly Gln Glu Tyr Pro Pro Pro Asn Leu Ala Phe Leu Glu Val Leu Ser
        995                 1000                1005            
Glu Phe Ser Ser Lys Leu Leu Arg Gln Asp Lys Lys Thr Val His Ser
    1010                1015                1020                
Tyr Leu Glu Lys Phe Leu Thr Glu Gln Met Met Glu Arg Arg Glu Asp
1025                1030                1035                1040
Val Trp Leu Pro Leu Ile Ser Tyr Arg Asn Ser Leu Val Thr Gly Gly
                1045                1050                1055    
Glu Asp Asp Arg Met Ser Val Asn Ser Gly Ser Ser Ser Ser Lys Thr
            1060                1065                1070        
Ser Ser Val Arg Asn Lys Lys Gly Arg Pro Pro Leu His Lys Lys Arg
        1075                1080                1085            
Val Glu Asp Glu Ser Leu Asp Asn Thr Trp Leu Asn Arg Thr Asp Thr
    1090                1095                1100                
Met Ile Gln Thr Pro Gly Pro Leu Pro Ala Pro Gln Leu Thr Ser Thr
1105                1110                1115                1120
Val Leu Arg Glu Asn Ser Arg Pro Met Gly Asp Gln Ile Gln Glu Pro
                1125                1130                1135    
Glu Ser Glu His Gly Ser Glu Pro Asp Phe Leu His Asn Pro Gln Met
            1140                1145                1150        
Gln Ile Ser Trp Leu Gly Gln Pro Lys Leu Glu Asp Leu Asn Arg Lys
        1155                1160                1165            
Asp Arg Thr Gly Met Asn Tyr Met Lys Val Arg Thr Gly Val Arg His
    1170                1175                1180                
Ala Val Arg Gly Leu Met Glu Glu Asp Ala Glu Pro Ile Phe Glu Asp
1185                1190                1195                1200
Val Met Met Ser Ser Arg Ser Gln Leu Glu Asp Met Asn Glu Glu Phe
                1205                1210                1215    
Glu Asp Thr Met Val Ile Asp Leu Pro Pro Ser Arg Asn Arg Arg Glu
            1220                1225                1230        
Arg Ala Glu Leu Arg Pro Asp Phe Phe Asp Ser Ala Ala Ile Ile Glu
        1235                1240                1245            
Asp Asp Ser Gly Phe Gly Met Pro Met Phe
    1250                1255            


<210> 7818
<211> 1231
<212> PRT
<213> Homo sapiens

<400> 7818
Met Ile Ala Ala Pro Glu Ile Pro Thr Asp Phe Asn Leu Leu Gln Glu
 1               5                  10                  15      
Ser Glu Thr His Phe Ser Ser Asp Thr Asp Phe Glu Asp Ile Glu Gly
            20                  25                  30          
Lys Asn Gln Lys Gln Gly Lys Gly Lys Thr Cys Lys Lys Gly Lys Lys
        35                  40                  45              
Gly Pro Ala Glu Lys Gly Lys Gly Gly Asn Gly Gly Gly Lys Pro Pro
    50                  55                  60                  
Ser Gly Pro Asn Arg Met Asn Gly His His Gln Gln Asn Gly Val Glu
65                  70                  75                  80  
Asn Met Met Leu Phe Glu Val Val Lys Met Gly Lys Ser Ala Met Gln
                85                  90                  95      
Ser Val Val Asp Asp Trp Ile Glu Ser Tyr Lys His Asp Arg Asp Ile
            100                 105                 110         
Ala Leu Leu Asp Leu Ile Asn Phe Phe Ile Gln Cys Ser Gly Cys Lys
        115                 120                 125             
Gly Val Val Thr Ala Glu Met Phe Arg His Met Gln Asn Ser Glu Ile
    130                 135                 140                 
Ile Arg Lys Met Thr Glu Glu Phe Asp Glu Asp Ser Gly Asp Tyr Pro
145                 150                 155                 160 
Leu Thr Met Ala Gly Pro Gln Trp Lys Lys Phe Lys Ser Ser Phe Cys
                165                 170                 175     
Glu Phe Ile Gly Val Leu Val Arg Gln Cys Gln Tyr Ser Ile Ile Tyr
            180                 185                 190         
Asp Glu Tyr Met Met Asp Thr Val Ile Ser Leu Leu Thr Gly Leu Ser
        195                 200                 205             
Asp Ser Gln Val Arg Ala Phe Arg His Thr Ser Thr Leu Ala Ala Met
    210                 215                 220                 
Lys Leu Met Thr Ala Leu Val Asn Val Ala Leu Asn Leu Ser Ile Asn
225                 230                 235                 240 
Met Asp Asn Thr Gln Arg Gln Tyr Glu Ala Glu Arg Asn Lys Met Ile
                245                 250                 255     
Gly Lys Arg Ala Asn Glu Arg Leu Glu Leu Leu Leu Gln Lys Arg Lys
            260                 265                 270         
Glu Leu Gln Glu Asn Gln Asp Glu Ile Glu Asn Met Met Asn Ala Ile
        275                 280                 285             
Phe Lys Gly Val Phe Val His Arg Tyr Arg Asp Ala Ile Ala Glu Ile
    290                 295                 300                 
Arg Ala Ile Cys Ile Glu Glu Ile Gly Ile Trp Met Lys Met Tyr Ser
305                 310                 315                 320 
Asp Ala Phe Leu Asn Asp Ser Tyr Leu Lys Tyr Val Gly Trp Thr Met
                325                 330                 335     
His Asp Lys Gln Gly Glu Val Arg Leu Lys Cys Leu Thr Ala Leu Gln
            340                 345                 350         
Gly Leu Tyr Tyr Asn Lys Glu Leu Asn Ser Lys Leu Glu Leu Phe Thr
        355                 360                 365             
Ser Arg Phe Lys Asp Arg Ile Val Ser Met Thr Leu Asp Lys Glu Tyr
    370                 375                 380                 
Asp Val Ala Val Gln Ala Ile Lys Leu Leu Thr Leu Val Leu Gln Ser
385                 390                 395                 400 
Ser Glu Glu Val Leu Thr Ala Glu Asp Cys Glu Asn Val Tyr His Leu
                405                 410                 415     
Val Tyr Ser Ala His Arg Pro Val Ala Val Ala Ala Gly Glu Phe Leu
            420                 425                 430         
Tyr Lys Lys Leu Phe Ser Arg Arg Asp Pro Glu Glu Asp Gly Met Met
        435                 440                 445             
Lys Arg Arg Gly Arg Gln Gly Pro Asn Ala Asn Leu Val Lys Thr Leu
    450                 455                 460                 
Val Phe Phe Phe Leu Glu Ser Glu Leu His Glu His Ala Ala Tyr Leu
465                 470                 475                 480 
Val Asp Ser Met Trp Asp Cys Ala Thr Glu Leu Leu Lys Asp Trp Glu
                485                 490                 495     
Cys Met Asn Ser Leu Leu Leu Glu Glu Pro Leu Ser Gly Glu Glu Ala
            500                 505                 510         
Leu Thr Asp Arg Gln Glu Ser Ala Leu Ile Glu Ile Met Leu Cys Thr
        515                 520                 525             
Ile Arg Gln Ala Ala Glu Cys His Pro Pro Val Gly Arg Gly Thr Gly
    530                 535                 540                 
Lys Arg Val Leu Thr Ala Lys Glu Lys Lys Thr Gln Leu Asp Asp Arg
545                 550                 555                 560 
Thr Lys Ile Thr Glu Leu Phe Ala Val Ala Leu Pro Gln Leu Leu Ala
                565                 570                 575     
Lys Tyr Ser Val Asp Ala Glu Lys Val Thr Asn Leu Leu Gln Leu Pro
            580                 585                 590         
Gln Tyr Phe Asp Leu Glu Ile Tyr Thr Thr Gly Arg Leu Glu Lys His
        595                 600                 605             
Leu Asp Ala Leu Leu Arg Gln Ile Arg Asn Ile Val Glu Lys His Thr
    610                 615                 620                 
Asp Thr Asp Val Leu Glu Ala Cys Ser Lys Thr Tyr His Ala Leu Cys
625                 630                 635                 640 
Asn Glu Glu Phe Thr Ile Phe Asn Arg Val Asp Ile Ser Arg Ser Gln
                645                 650                 655     
Leu Ile Asp Glu Leu Ala Asp Lys Phe Asn Arg Leu Leu Glu Asp Phe
            660                 665                 670         
Leu Gln Glu Gly Glu Glu Pro Asp Glu Asp Asp Ala Tyr Gln Val Leu
        675                 680                 685             
Ser Thr Leu Lys Arg Ile Thr Ala Phe His Asn Ala His Asp Leu Ser
    690                 695                 700                 
Lys Trp Asp Leu Phe Ala Cys Asn Tyr Lys Leu Leu Lys Thr Gly Ile
705                 710                 715                 720 
Glu Asn Gly Asp Met Pro Glu Gln Ile Val Ile His Ala Leu Gln Cys
                725                 730                 735     
Thr His Tyr Val Ile Leu Trp Gln Leu Ala Lys Ile Thr Glu Ser Ser
            740                 745                 750         
Ser Thr Lys Glu Asp Leu Leu Arg Leu Lys Lys Gln Met Arg Val Phe
        755                 760                 765             
Cys Gln Ile Cys Gln His Tyr Leu Thr Asn Val Asn Thr Thr Val Lys
    770                 775                 780                 
Glu Gln Ala Phe Thr Ile Leu Cys Asp Ile Leu Met Ile Phe Ser His
785                 790                 795                 800 
Gln Ile Met Ser Gly Gly Arg Asp Met Leu Glu Pro Leu Val Tyr Thr
                805                 810                 815     
Pro Asp Ser Ser Leu Gln Ser Glu Leu Leu Ser Phe Ile Leu Asp His
            820                 825                 830         
Val Phe Ile Glu Gln Asp Asp Asp Asn Asn Ser Ala Asp Gly Gln Gln
        835                 840                 845             
Glu Asp Glu Ala Ser Lys Ile Glu Ala Leu His Lys Arg Arg Asn Leu
    850                 855                 860                 
Leu Ala Ala Phe Cys Lys Leu Ile Val Tyr Thr Val Val Glu Met Asn
865                 870                 875                 880 
Thr Ala Ala Asp Ile Phe Lys Gln Tyr Met Lys Tyr Tyr Asn Asp Tyr
                885                 890                 895     
Gly Asp Ile Ile Lys Glu Thr Met Ser Lys Thr Arg Gln Ile Asp Lys
            900                 905                 910         
Ile Gln Cys Ala Lys Thr Leu Ile Leu Ser Leu Gln Gln Leu Phe Asn
        915                 920                 925             
Glu Met Ile Gln Glu Asn Gly Tyr Asn Phe Asp Arg Ser Ser Ser Thr
    930                 935                 940                 
Phe Ser Gly Ile Lys Glu Leu Ala Arg Arg Phe Ala Leu Thr Phe Gly
945                 950                 955                 960 
Leu Asp Gln Leu Lys Thr Arg Glu Ala Ile Ala Met Leu His Lys Asp
                965                 970                 975     
Gly Ile Glu Phe Ala Phe Lys Glu Pro Asn Pro Gln Gly Glu Ser His
            980                 985                 990         
Pro Pro Leu Asn Leu Ala Phe Leu Asp Ile Leu Ser Glu Phe Ser Ser
        995                 1000                1005            
Lys Leu Leu Arg Gln Asp Lys Arg Thr Val Tyr Val Tyr Leu Glu Lys
    1010                1015                1020                
Phe Met Thr Phe Gln Met Ser Leu Arg Arg Glu Asp Val Trp Leu Pro
1025                1030                1035                1040
Leu Met Ser Tyr Arg Asn Ser Leu Leu Ala Gly Gly Asp Asp Asp Thr
                1045                1050                1055    
Met Ser Val Ile Ser Gly Ile Ser Ser Arg Gly Ser Thr Val Arg Ser
            1060                1065                1070        
Lys Lys Ser Lys Pro Ser Thr Gly Lys Arg Lys Val Val Glu Gly Met
        1075                1080                1085            
Gln Leu Ser Leu Thr Glu Glu Ser Ser Ser Ser Asp Ser Met Trp Leu
    1090                1095                1100                
Ser Arg Glu Gln Thr Leu His Thr Pro Val Met Met Gln Thr Pro Gln
1105                1110                1115                1120
Leu Thr Ser Thr Ile Met Arg Glu Pro Lys Arg Leu Arg Pro Glu Asp
                1125                1130                1135    
Ser Phe Met Ser Val Tyr Pro Met Gln Thr Glu His His Gln Thr Pro
            1140                1145                1150        
Leu Asp Tyr Asn Arg Arg Gly Thr Ser Leu Met Glu Asp Asp Glu Glu
        1155                1160                1165            
Pro Ile Val Glu Asp Val Met Met Ser Ser Glu Gly Arg Ile Glu Asp
    1170                1175                1180                
Leu Asn Glu Gly Met Asp Phe Asp Thr Met Asp Ile Asp Leu Pro Pro
1185                1190                1195                1200
Ser Lys Asn Arg Arg Glu Arg Thr Glu Leu Lys Pro Asp Phe Phe Asp
                1205                1210                1215    
Pro Ala Ser Ile Met Asp Glu Ser Val Leu Gly Val Ser Met Phe
            1220                1225                1230    


<210> 7819
<211> 273
<212> PRT
<213> Homo sapiens

<400> 7819
Met Lys Arg Gln Gly Ala Ser Ser Glu Arg Lys Arg Ala Arg Ile Pro
 1               5                  10                  15      
Ser Gly Lys Ala Gly Ala Ala Asn Gly Phe Leu Met Glu Val Cys Val
            20                  25                  30          
Asp Ser Val Glu Ser Ala Val Asn Ala Glu Arg Gly Gly Ala Asp Arg
        35                  40                  45              
Ile Glu Leu Cys Ser Gly Leu Ser Glu Gly Gly Thr Thr Pro Ser Met
    50                  55                  60                  
Gly Val Leu Gln Val Val Lys Gln Ser Val Gln Ile Pro Val Phe Val
65                  70                  75                  80  
Met Ile Arg Pro Arg Gly Gly Asp Phe Leu Tyr Ser Asp Arg Glu Ile
                85                  90                  95      
Glu Val Met Lys Ala Asp Ile Arg Leu Ala Lys Leu Tyr Gly Ala Asp
            100                 105                 110         
Gly Leu Val Phe Gly Ala Leu Thr Glu Asp Gly His Ile Asp Lys Glu
        115                 120                 125             
Leu Cys Met Ser Leu Met Ala Ile Cys Arg Pro Leu Pro Val Thr Phe
    130                 135                 140                 
His Arg Ala Phe Asp Met Val His Asp Pro Met Ala Ala Leu Glu Thr
145                 150                 155                 160 
Leu Leu Thr Leu Gly Phe Glu Arg Val Leu Thr Ser Gly Cys Asp Ser
                165                 170                 175     
Ser Ala Leu Glu Gly Leu Pro Leu Ile Lys Arg Leu Ile Glu Gln Ala
            180                 185                 190         
Lys Gly Arg Ile Val Val Met Pro Gly Gly Gly Ile Thr Asp Arg Asn
        195                 200                 205             
Leu Gln Arg Ile Leu Glu Gly Ser Gly Ala Thr Glu Phe His Cys Ser
    210                 215                 220                 
Ala Arg Ser Thr Arg Asp Ser Gly Met Lys Phe Arg Asn Ser Ser Val
225                 230                 235                 240 
Ala Met Gly Ala Ser Leu Ser Cys Ser Glu Tyr Ser Leu Lys Val Thr
                245                 250                 255     
Asp Val Thr Lys Val Arg Thr Leu Asn Ala Ile Ala Lys Asn Ile Leu
            260                 265                 270         
Val
    


<210> 7820
<211> 651
<212> PRT
<213> Homo sapiens

<400> 7820
Met Ala Arg Val Cys Arg Arg Gln Gln Cys Ser Val Glu Arg Arg Gly
 1               5                  10                  15      
Phe Arg Gln Glu Leu Asp Ser Trp Arg His Lys Leu Ile His Cys Val
            20                  25                  30          
Gly Gly Asp Gly Gly Gly Gly Ser Trp Ser Cys His Ser Pro Arg Val
        35                  40                  45              
Arg Leu Thr Glu Pro Ser Gly Val Ser Trp Pro Arg Gly Ala Ala Ala
    50                  55                  60                  
Ala Leu Pro Gln Arg Ala Ala Val Ala Gly Glu Leu Ile Leu Asp Ala
65                  70                  75                  80  
Arg Val Gly Val Ser Arg Phe Pro Leu Cys Gly Gly Arg Arg Asp His
                85                  90                  95      
Lys Gly Leu Thr His Ile Phe Asn Pro Pro Pro Lys Arg Phe Glu Ser
            100                 105                 110         
Ile Leu Glu Gly Leu Phe Gly Pro Ala Leu Leu Lys Asp Leu Ser Leu
        115                 120                 125             
Phe Lys Asp Cys Glu Pro Glu Ser Ile Ser Asp Trp Thr Phe Asp Glu
    130                 135                 140                 
Asn Cys Leu Phe Cys Cys Leu Arg Arg Asp Lys Val Lys Gly His Leu
145                 150                 155                 160 
Val Gly Leu Asp Glu Pro Ala Ser Gly Ala Gly Gln Glu Ala Leu Leu
                165                 170                 175     
Lys Gln Glu Gln Ala Lys Ile Ile Arg Phe Glu Arg Gln Ala Glu Glu
            180                 185                 190         
Phe Leu Asn Ala Val Phe Tyr Arg Lys Asp Ser Pro Trp Val Ser Asp
        195                 200                 205             
Pro Asn Ile Pro Leu Val Ala Arg Glu Ile Met Gln Arg Met Ile Gln
    210                 215                 220                 
Gln Phe Ala Ala Glu Tyr Thr Ser Lys Asn Ser Ser Thr Gln Asp Pro
225                 230                 235                 240 
Ser Gln Pro Asn Ser Thr Lys Asn Gln Ser Leu Pro Lys Ala Ser Pro
                245                 250                 255     
Val Thr Thr Ser Pro Thr Ala Ala Thr Thr Gln Asn Pro Val Leu Ser
            260                 265                 270         
Lys Leu Leu Met Ala Asp Gln Asp Ser Pro Leu Asp Leu Thr Val Arg
        275                 280                 285             
Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp Gly Val Leu Asp Leu Ser
    290                 295                 300                 
Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr Ser Leu Ser His Ser Pro
305                 310                 315                 320 
Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg Pro Gly Arg Pro Ser Gln
                325                 330                 335     
Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp Gly Val Pro Pro Arg Ser
            340                 345                 350         
Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly His Ser Thr Ser Leu Lys
        355                 360                 365             
Val Pro Leu Ala Arg Ser Leu Gln Ile Ser Glu Glu Leu Leu Ser Arg
    370                 375                 380                 
Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly Pro Ser Gly Leu Gln Asn
385                 390                 395                 400 
His Gly Gln His Leu Ile Leu Ser Arg Glu Ala Ser Trp Ala Lys Pro
                405                 410                 415     
His Tyr Glu Phe Asn Leu Ser Arg Met Lys Phe Arg Gly Asn Gly Ala
            420                 425                 430         
Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu Ala Glu Asn Ser Ala Phe
        435                 440                 445             
Pro Lys Met Ala Leu Gln Ala Lys Gln Asp Gly Lys Lys Asp Val Ser
    450                 455                 460                 
His Ser Ser Pro Val Asp Leu Lys Ile Pro Gln Val Arg Gly Met Asp
465                 470                 475                 480 
Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln Tyr Ser Tyr Ser Ser Leu
                485                 490                 495     
Val Met Gly Ser Gln Thr Glu Ser Ala Leu Ser Lys Lys Leu Arg Ala
            500                 505                 510         
Ile Leu Pro Lys Gln Ser Arg Lys Ser Met Leu Asp Ala Gly Pro Asp
        515                 520                 525             
Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr Ser Gly Gln Pro Tyr Pro
    530                 535                 540                 
Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser Lys Gln Pro Arg Lys Lys
545                 550                 555                 560 
Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu Ile Leu Glu Glu Ala Ile
                565                 570                 575     
Ser Val Val Met Ser Gly Lys Met Ser Val Ser Lys Ala Gln Ser Ile
            580                 585                 590         
Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr Lys Val Lys Glu Arg Leu
        595                 600                 605             
Gly Thr Leu Lys Asn Pro Pro Lys Lys Lys Met Lys Leu Met Arg Ser
    610                 615                 620                 
Glu Gly Pro Asp Val Ser Val Lys Ile Glu Leu Asp Pro Gln Gly Glu
625                 630                 635                 640 
Ala Ala Gln Ser Ala Asn Glu Ser Lys Asn Glu
                645                 650     


<210> 7821
<211> 433
<212> PRT
<213> Homo sapiens

<400> 7821
Met Gln Arg Met Ile Gln Gln Phe Ala Ala Glu Tyr Thr Ser Lys Asn
 1               5                  10                  15      
Ser Ser Thr Gln Asp Pro Ser Gln Pro Asn Ser Thr Lys Asn Gln Ser
            20                  25                  30          
Leu Pro Lys Ala Ser Pro Val Thr Thr Ser Pro Thr Ala Ala Thr Thr
        35                  40                  45              
Gln Asn Pro Val Leu Ser Lys Leu Leu Met Ala Asp Gln Asp Ser Pro
    50                  55                  60                  
Leu Asp Leu Thr Val Arg Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp
65                  70                  75                  80  
Gly Val Leu Asp Leu Ser Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr
                85                  90                  95      
Ser Leu Ser His Ser Pro Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg
            100                 105                 110         
Pro Gly Arg Pro Ser Gln Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp
        115                 120                 125             
Gly Val Pro Pro Arg Ser Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly
    130                 135                 140                 
His Ser Thr Ser Leu Lys Val Pro Leu Ala Arg Ser Leu Gln Ile Ser
145                 150                 155                 160 
Glu Glu Leu Leu Ser Arg Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly
                165                 170                 175     
Pro Ser Gly Leu Gln Asn His Gly Gln His Leu Ile Leu Ser Arg Glu
            180                 185                 190         
Ala Ser Trp Ala Lys Pro His Tyr Glu Phe Asn Leu Ser Arg Met Lys
        195                 200                 205             
Phe Arg Gly Asn Gly Ala Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu
    210                 215                 220                 
Ala Glu Asn Ser Ala Phe Pro Lys Met Ala Leu Gln Ala Lys Gln Asp
225                 230                 235                 240 
Gly Lys Lys Asp Val Ser His Ser Ser Pro Val Asp Leu Lys Ile Pro
                245                 250                 255     
Gln Val Arg Gly Met Asp Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln
            260                 265                 270         
Tyr Ser Tyr Ser Ser Leu Val Met Gly Ser Gln Thr Glu Ser Ala Leu
        275                 280                 285             
Ser Lys Lys Leu Arg Ala Ile Leu Pro Lys Gln Ser Arg Lys Ser Met
    290                 295                 300                 
Leu Asp Ala Gly Pro Asp Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr
305                 310                 315                 320 
Pro Gly Gln Pro Tyr Pro Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser
                325                 330                 335     
Lys Gln Pro Arg Lys Lys Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu
            340                 345                 350         
Ile Leu Glu Glu Ala Ile Ser Val Val Met Ser Gly Lys Met Ser Val
        355                 360                 365             
Ser Lys Ala Gln Ser Ile Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr
    370                 375                 380                 
Lys Val Lys Glu Arg Leu Gly Thr Leu Lys Asn Pro Pro Lys Lys Lys
385                 390                 395                 400 
Met Lys Leu Met Arg Ser Glu Gly Pro Asp Val Ser Val Lys Ile Glu
                405                 410                 415     
Leu Asp Pro Gln Gly Glu Ala Ala Gln Ser Ala Asn Glu Ser Lys Asn
            420                 425                 430         
Glu
    


<210> 7822
<211> 426
<212> PRT
<213> Homo sapiens

<400> 7822
Met Cys Leu Gly Ser Val Gln Trp Arg Ile Arg Lys Glu Leu Asp Ala
 1               5                  10                  15      
Thr Gln Arg Gly Gln Gly Pro Pro Glu Asp Ser Ala Gly Gln Ile Ala
            20                  25                  30          
Glu Leu Ser His Asp Met Ile Met Glu Ile Thr Thr Leu Arg Ala Gln
        35                  40                  45              
Leu Thr Asp Leu Glu Glu Val Asn Leu Asn Leu Lys Lys Gln Ile Arg
    50                  55                  60                  
Lys Glu Val Gln Glu Glu Tyr Glu Ala Leu Val Arg Ala Leu Phe Glu
65                  70                  75                  80  
Thr Cys Leu His Ile Lys Glu Lys Leu Asp Asp Asn Gln Leu Asn Leu
                85                  90                  95      
Ile Gln Lys Val Cys Glu Leu Ile Gly Glu Val Arg Thr Glu Gly Ile
            100                 105                 110         
Asp Asn Met Lys Asp Leu Lys Lys Lys Trp Cys Ser Ala Ser Pro Asp
        115                 120                 125             
Glu Gly Met Lys Glu Asn Pro Ala Lys Glu Gln Leu Trp Ala Leu Glu
    130                 135                 140                 
Gln Asp Asn Cys Ser Leu Ala Asn Leu Val Cys Lys Val Arg Ser Leu
145                 150                 155                 160 
Gly Arg Trp Arg Leu Ala Val Gln Gln Ala Cys Phe Gln Ala Gln Leu
                165                 170                 175     
Ser Arg Thr Glu Lys Glu Ser Ile Gln Ser Lys Lys Glu Tyr Leu Arg
            180                 185                 190         
Ile Lys Leu Met Ala Glu Arg Glu Val Gly Leu Phe Arg Gln Gln Val
        195                 200                 205             
Leu Ala Leu Arg Gln Ala Leu Ala Arg Ala Gln Ala Asp Ser Ala Arg
    210                 215                 220                 
Met Trp Lys Gln Gln Asp Ser Gln Ala Gln Leu Leu Lys Glu Leu Glu
225                 230                 235                 240 
His Arg Val Thr Gln Glu Ala Leu Thr Gln Gln Gln Leu His Phe Met
                245                 250                 255     
Lys Thr Ser Arg Met Glu Lys Leu Leu Glu Asp Val Gly Gln Lys Glu
            260                 265                 270         
Gln Gln Leu Gln Leu Leu Ser Lys Glu Ala Glu Arg Ala Ser Lys Leu
        275                 280                 285             
Gly Gln Leu Gln Gln Lys Lys Met Lys Arg Asp Leu His Gln Met Arg
    290                 295                 300                 
Ser Arg Leu Ala Gln Glu Arg Ser Val Lys Leu Asp Ala Leu Gln Arg
305                 310                 315                 320 
Ala Glu Glu Leu Gln Gly Gln Leu His Asp Ala Gln Arg Ser Ala Val
                325                 330                 335     
Pro Met Gly Ser Ser Gly Asp Leu Ile Ser Gln Ala Gln Tyr Ser Pro
            340                 345                 350         
Thr Ser Ala Ser Thr Ser Ser Arg Tyr Ser Gln Gln Arg Phe Leu Lys
        355                 360                 365             
Thr Asn Leu Lys Gly Ser Lys Ile Thr Arg Trp Ile Gln Arg Pro Gln
    370                 375                 380                 
Thr Val Pro Ile Lys His Lys Lys Arg Thr Asp Asp Val Phe Leu Pro
385                 390                 395                 400 
Asn Met Ala Glu Asn Val Gln Leu Thr Ala Phe Gln Val Gln Thr Ala
                405                 410                 415     
Pro Ser Arg Phe Pro Phe Arg Ala Asp Trp
            420                 425     


<210> 7823
<211> 781
<212> PRT
<213> Homo sapiens

<400> 7823
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser
 1               5                  10                  15      
Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val
            20                  25                  30          
Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp
        35                  40                  45              
Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr
    50                  55                  60                  
Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu
65                  70                  75                  80  
Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn
                85                  90                  95      
Thr Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Thr Asp Arg Ser
            100                 105                 110         
Asn Gln Ser His Leu Val Gly Val Pro Lys Pro Gly Val Pro Gln Thr
        115                 120                 125             
Pro Val Asn Lys Ile Asp Glu His Phe Val Ala Asp Ser Arg Ala Gln
    130                 135                 140                 
Asn Gln Pro Ser Ser Ile Cys Ser Thr Thr Thr Ser Thr Pro Ala Ala
145                 150                 155                 160 
Val Pro Val Gln Gln Ser Lys Arg Gly Thr Met Gly Trp Gln Lys Ala
                165                 170                 175     
Gly His Pro Pro Ser Asp Gly Gln Gln Arg Ala Thr Gln Gln Gly Ser
            180                 185                 190         
Leu Arg Thr Leu Leu Gly Asp Gly Val Gly Arg Gln Gln Pro Arg Ala
        195                 200                 205             
Lys Gln Val Cys Asn Val Glu Val Gly Leu Gln Thr Gln Glu Arg Pro
    210                 215                 220                 
Pro Ala Met Ala Ala Lys His Ser Ser Ser Gly His Cys Val Gln Asn
225                 230                 235                 240 
Phe Pro Pro Ser Leu Ala Ser Lys Pro Ser Leu Val Gln Gln Lys Pro
                245                 250                 255     
Thr Ala Tyr Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Glu
            260                 265                 270         
Ser Pro Lys Leu Lys Ser Ser Ser Glu Thr Ser Val His Cys Thr Ser
        275                 280                 285             
Tyr Arg Gly Val Pro Ala Ser Lys Pro Glu Pro Ala Arg Ala Lys Ala
    290                 295                 300                 
Lys Leu Ser Lys Phe Ser Ile Pro Lys Gln Gly Glu Glu Ser Arg Ser
305                 310                 315                 320 
Gly Glu Thr Asn Ser Cys Val Glu Glu Ile Ile Arg Glu Met Thr Trp
                325                 330                 335     
Leu Pro Pro Leu Ser Ala Ile Gln Ala Pro Gly Lys Val Glu Pro Thr
            340                 345                 350         
Lys Phe Pro Phe Pro Asn Lys Asp Ser Gln Leu Val Ser Ser Gly His
        355                 360                 365             
Asn Asn Pro Lys Lys Gly Asp Ala Glu Pro Glu Ser Pro Asp Asn Gly
    370                 375                 380                 
Thr Ser Asn Thr Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp
385                 390                 395                 400 
Glu Glu Glu Asn Glu Gln Gln Ala Ala Gln Arg Thr Ala Leu Arg Ala
                405                 410                 415     
Leu Ser Asp Ser Ala Val Val Gln Gln Pro Asn Cys Arg Thr Ser Val
            420                 425                 430         
Pro Ser Ser Lys Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser
        435                 440                 445             
Ser Ser Ser Asp Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Thr Glu
    450                 455                 460                 
Ser Ser Ser Ser Glu Ser Glu Gly Ser Lys Pro Pro His Phe Ser Ser
465                 470                 475                 480 
Pro Glu Ala Glu Pro Ala Ser Ser Asn Lys Trp Gln Leu Asp Lys Trp
                485                 490                 495     
Leu Asn Lys Val Asn Pro His Lys Pro Pro Ile Leu Ile Gln Asn Glu
            500                 505                 510         
Ser His Gly Ser Glu Ser Asn Gln Tyr Tyr Asn Pro Val Lys Glu Asp
        515                 520                 525             
Val Gln Asp Cys Gly Lys Val Pro Asp Val Cys Gln Pro Ser Leu Arg
    530                 535                 540                 
Glu Lys Glu Ile Lys Ser Thr Cys Lys Glu Glu Gln Arg Pro Arg Thr
545                 550                 555                 560 
Ala Asn Lys Ala Pro Gly Ser Lys Gly Val Lys Gln Lys Ser Pro Pro
                565                 570                 575     
Ala Ala Val Ala Val Ala Val Ser Ala Ala Ala Pro Pro Pro Ala Val
            580                 585                 590         
Pro Cys Ala Pro Ala Glu Asn Ala Pro Ala Pro Ala Arg Arg Ser Ala
        595                 600                 605             
Gly Lys Lys Pro Thr Arg Arg Thr Glu Arg Thr Ser Ala Gly Asp Gly
    610                 615                 620                 
Ala Asn Cys His Arg Pro Glu Glu Pro Ala Ala Ala Asp Ala Leu Gly
625                 630                 635                 640 
Thr Ser Val Val Val Pro Pro Glu Pro Thr Lys Thr Arg Pro Cys Gly
                645                 650                 655     
Asn Asn Arg Ala Ser His Arg Lys Glu Leu Arg Ser Ser Val Thr Cys
            660                 665                 670         
Glu Lys Arg Arg Thr Arg Gly Leu Ser Arg Ile Val Pro Lys Ser Lys
        675                 680                 685             
Glu Phe Ile Glu Thr Glu Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser
    690                 695                 700                 
Asp Leu Glu Ser Glu Gln Glu Glu Tyr Pro Leu Ser Lys Ala Gln Thr
705                 710                 715                 720 
Val Ala Ala Ser Ala Ser Ser Gly Asn Asp Gln Arg Leu Lys Glu Ala
                725                 730                 735     
Ala Ala Asn Gly Gly Ser Gly Pro Arg Ala Pro Val Gly Ser Ile Asn
            740                 745                 750         
Ala Arg Thr Thr Ser Asp Ile Ala Lys Glu Leu Glu Glu Gln Phe Tyr
        755                 760                 765             
Thr Leu Val Pro Leu Ala Gly Thr Asn Phe Ser Pro Leu
    770                 775                 780     


<210> 7824
<211> 4502
<212> PRT
<213> Homo sapiens

<400> 7824
Met Met Lys Leu Tyr Ile Asp Asn Ala Ala Pro Asp Lys Leu Lys Gly
 1               5                  10                  15      
Leu Cys Ile Phe Phe Val Arg Cys Arg Asn Asp Val Ala Ile Asn Val
            20                  25                  30          
Lys Thr Ile Gln Glu Glu Ala Leu Phe Thr Val Leu Asp Ala Ser Lys
        35                  40                  45              
Gly Leu Leu Asn Gly Ile Arg Asp Met Leu Ala Asn Ile Phe Leu Pro
    50                  55                  60                  
Ala Val Leu Ala Thr Asn Asn Trp Gly Ala Leu Asn Gln Ser Lys Gln
65                  70                  75                  80  
Gly Glu Ser Glu Lys His Ile Phe Thr Glu Thr Ile Asn Arg Tyr Leu
                85                  90                  95      
Ser Phe Leu Asp Gly Ala Arg Ile Ser Ile Glu Gly Thr Val Lys Leu
            100                 105                 110         
Lys Thr Ile Asp Asn Val Asn Phe Ser Lys Leu His Thr Phe Glu Glu
        115                 120                 125             
Val Thr Ala Ala Ala Ser Asn Ser Glu Thr Val His Gln Leu Glu Glu
    130                 135                 140                 
Val Leu Met Val Trp Tyr Lys Gln Ile Glu Gln Val Leu Ile Glu Ser
145                 150                 155                 160 
Glu Gln Met Arg Lys Glu Ala Gly Asp Ser Gly Pro Leu Thr Glu Leu
                165                 170                 175     
Glu His Trp Lys Arg Met Ser Ala Lys Phe Asn Tyr Ile Ile Glu Gln
            180                 185                 190         
Ile Lys Gly Pro Ser Cys Lys Ala Val Ile Asn Val Leu Asn Val Ala
        195                 200                 205             
His Ser Lys Leu Leu Lys Asn Trp Arg Asp Leu Asp Ala Arg Ile Thr
    210                 215                 220                 
Asp Thr Ala Asn Glu Ser Lys Asp Asn Val Arg Tyr Leu Tyr Thr Leu
225                 230                 235                 240 
Glu Lys Val Cys Gln Pro Leu Tyr Asn His Asp Leu Val Ser Met Ala
                245                 250                 255     
His Gly Ile Gln Asn Leu Ile Asn Ala Ile Arg Met Ile His Gly Val
            260                 265                 270         
Ser Arg Tyr Tyr Asn Thr Ser Glu Arg Met Thr Ser Leu Phe Ile Lys
        275                 280                 285             
Val Thr Asn Gln Met Val Thr Ala Cys Lys Ala Tyr Ile Thr Asp Gly
    290                 295                 300                 
Gly Leu Asn His Val Trp Asp Gln Glu Thr Pro Val Val Leu Lys Lys
305                 310                 315                 320 
Ile Gln Asp Cys Ile Phe Leu Phe Lys Glu Tyr Gln Ala Ser Phe His
                325                 330                 335     
Lys Thr Arg Lys Leu Ile Ser Glu Ser Ser Gly Glu Lys Ser Phe Glu
            340                 345                 350         
Val Ser Glu Met Tyr Ile Phe Gly Lys Phe Glu Ala Phe Cys Lys Arg
        355                 360                 365             
Leu Glu Lys Ile Thr Glu Met Ile Thr Val Val Gln Thr Tyr Ser Thr
    370                 375                 380                 
Leu Ser Asn Ser Thr Ile Glu Gly Ile Asp Ile Met Ala Ile Lys Phe
385                 390                 395                 400 
Arg Asn Ile Tyr Gln Gly Val Lys Lys Lys Gln Tyr Asp Ile Leu Asp
                405                 410                 415     
Pro Arg Arg Thr Glu Phe Asp Thr Asp Phe Leu Asp Phe Met Thr Lys
            420                 425                 430         
Ile Asn Gly Leu Glu Val Gln Ile Gln Ala Phe Met Asn Ser Ser Phe
        435                 440                 445             
Gly Lys Ile Leu Ser Ser Gln Gln Ala Leu Gln Leu Leu Gln Arg Phe
    450                 455                 460                 
Gln Lys Leu Asn Ile Pro Cys Leu Gly Leu Glu Ile Asn His Thr Ile
465                 470                 475                 480 
Glu Arg Ile Leu Gln Tyr Tyr Val Ala Glu Leu Asp Ala Thr Lys Lys
                485                 490                 495     
Ala Ser Leu Tyr His Ser Gln Lys Asp Asp Pro Pro Leu Ala Arg Asn
            500                 505                 510         
Met Pro Pro Ile Ala Gly Lys Ile Leu Trp Val Arg Gln Leu Tyr Arg
        515                 520                 525             
Arg Ile Ser Glu Pro Ile Asn Tyr Phe Phe Lys Asn Ser Asp Ile Leu
    530                 535                 540                 
Ser Ser Pro Asp Gly Lys Ala Val Ile Arg Gln Tyr Asn Lys Ile Ser
545                 550                 555                 560 
Tyr Val Leu Val Glu Phe Glu Val Val Tyr His Thr Ala Trp Ile Arg
                565                 570                 575     
Glu Ile Ser Gln Leu His Tyr Ala Leu Gln Ala Thr Leu Phe Val Arg
            580                 585                 590         
His Pro Glu Thr Gly Lys Leu Leu Val Asn Phe Asp Pro Lys Ile Leu
        595                 600                 605             
Glu Val Val Arg Glu Thr Lys Cys Met Ile Lys Met Lys Leu Asp Val
    610                 615                 620                 
Pro Glu Gln Ala Lys Arg Leu Leu Lys Leu Glu Ser Lys Leu Lys Ala
625                 630                 635                 640 
Asp Lys Leu Tyr Leu Gln Gly Leu Leu Gln Tyr Tyr Asp Glu Leu Cys
                645                 650                 655     
Gln Glu Val Pro Ser Val Phe Val Asn Leu Met Thr Pro Lys Met Lys
            660                 665                 670         
Lys Val Glu Ser Val Leu Arg Gln Gly Leu Thr Val Leu Thr Trp Ser
        675                 680                 685             
Ser Leu Thr Leu Glu Ser Phe Phe Gln Glu Val Glu Leu Val Leu Asp
    690                 695                 700                 
Met Phe Asn Gln Leu Leu Lys Lys Ile Ser Asp Leu Cys Glu Met His
705                 710                 715                 720 
Ile Asp Thr Val Leu Lys Glu Ile Ala Lys Thr Val Leu Ile Ser Leu
                725                 730                 735     
Pro Glu Ser Gly Ala Thr Lys Val Glu Asp Met Leu Thr Leu Asn Glu
            740                 745                 750         
Thr Tyr Thr Lys Glu Trp Ala Asp Ile Leu Asn His Lys Ser Lys His
        755                 760                 765             
Val Glu Glu Ala Val Arg Glu Leu Ile Ser Ile Phe Glu Gln Ile Tyr
    770                 775                 780                 
Glu Val Lys Tyr Thr Gly Lys Val Gly Lys Gln Ser Glu Gln Arg Lys
785                 790                 795                 800 
His Val Val Phe Gly Ser Glu Thr Gly Glu Gly Glu Asn Asn Asp Tyr
                805                 810                 815     
Glu Ala Asn Ile Val Asn Glu Phe Asp Thr His Asp Lys Glu Asp Glu
            820                 825                 830         
Phe Lys Lys Glu Cys Lys Glu Val Phe Ala Phe Phe Ser His Gln Leu
        835                 840                 845             
Leu Asp Ser Leu Gln Lys Ala Thr Arg Leu Ser Leu Asp Thr Met Lys
    850                 855                 860                 
Arg Arg Ile Phe Val Ala Arg Gln Val Glu Asn Met Leu Ile Ile Leu
865                 870                 875                 880 
Tyr Gly Arg Lys Gln Ser Glu Asp Ile Ile Ser Phe Ile Lys Ser Glu
                885                 890                 895     
Val His Leu Ala Ile Pro Asn Val Val Met Ile Pro Ser Leu Asp Asp
            900                 905                 910         
Ile Gln Gln Ala Ile Asn Arg Met Ile Gln Leu Thr Leu Glu Val Ser
        915                 920                 925             
Arg Gly Val Ala His Trp Gly Gln Gln Gln Ile Arg Pro Ile Lys Ser
    930                 935                 940                 
Val Ile Pro Ser Pro Thr Thr Thr Asp Val Thr His Gln Asn Thr Gly
945                 950                 955                 960 
Lys Leu Leu Lys Lys Glu Glu Arg Ser Phe Glu Glu Ala Ile Pro Ala
                965                 970                 975     
Arg Lys Leu Lys Asn Phe Tyr Pro Gly Val Ala Glu His Lys Asp Ile
            980                 985                 990         
Ser Lys Leu Val Leu Leu Leu Ser Ser Ser Val Asn Ser Leu Arg Lys
        995                 1000                1005            
Ala Ala His Glu Ala Leu Gln Asp Phe Gln Lys Tyr Lys Thr Leu Trp
    1010                1015                1020                
Thr Glu Asp Arg Asp Val Lys Val Lys Glu Phe Leu Ala Asn Asn Pro
1025                1030                1035                1040
Ser Leu Thr Glu Ile Arg Ser Glu Ile Leu His Tyr Ala Thr Phe Glu
                1045                1050                1055    
Gln Glu Ile Asp Glu Leu Lys Pro Ile Ile Val Val Gly Ala Leu Glu
            1060                1065                1070        
Leu His Thr Glu Pro Met Lys Leu Ala Leu Ser Ile Glu Ala Lys Ala
        1075                1080                1085            
Trp Lys Met Leu Leu Cys Arg Tyr Leu Asn Glu Glu Tyr Lys Lys Lys
    1090                1095                1100                
Met Ser Tyr Met Ile Ala Phe Ile Asn Glu Tyr Leu Lys Lys Leu Ser
1105                1110                1115                1120
Arg Pro Ile Arg Asp Leu Asp Asp Val Arg Phe Ala Met Glu Ala Leu
                1125                1130                1135    
Ser Cys Ile Arg Asp Asn Glu Ile Gln Met Asp Met Thr Leu Gly Pro
            1140                1145                1150        
Ile Glu Glu Ala Tyr Ala Ile Leu Asn Arg Phe Glu Val Glu Val Thr
        1155                1160                1165            
Lys Glu Glu Ser Glu Ala Val Asp Thr Leu Arg Tyr Ser Phe Asn Lys
    1170                1175                1180                
Leu Gln Ser Lys Ala Val Ser Val Gln Glu Asp Leu Val Gln Val Gln
1185                1190                1195                1200
Pro Lys Phe Lys Ser Asn Leu Leu Glu Ser Val Glu Val Phe Arg Glu
                1205                1210                1215    
Asp Val Ile Asn Phe Ala Glu Ala Tyr Glu Leu Glu Gly Pro Met Val
            1220                1225                1230        
Pro Asn Ile Pro Pro Gln Glu Ala Ser Asn Arg Leu Gln Ile Phe Gln
        1235                1240                1245            
Ala Ser Phe Asp Asp Leu Trp Arg Lys Phe Val Thr Tyr Ser Ser Gly
    1250                1255                1260                
Glu Gln Leu Phe Gly Leu Pro Val Thr Asp Tyr Glu Val Leu His Lys
1265                1270                1275                1280
Thr Arg Lys Glu Leu Asn Leu Leu Gln Lys Leu Tyr Gly Leu Tyr Asp
                1285                1290                1295    
Thr Val Met Ser Ser Ile Ser Gly Tyr Tyr Glu Ile Leu Trp Gly Asp
            1300                1305                1310        
Val Asp Ile Glu Lys Ile Asn Ala Glu Leu Leu Glu Phe Gln Asn Arg
        1315                1320                1325            
Cys Arg Lys Leu Pro Lys Gly Leu Lys Asp Trp Gln Ala Phe Leu Asp
    1330                1335                1340                
Leu Lys Lys Arg Ile Asp Asp Phe Ser Glu Ser Cys Pro Leu Leu Glu
1345                1350                1355                1360
Met Met Thr Asn Lys Ala Met Lys Gln Arg His Trp Asp Arg Ile Ser
                1365                1370                1375    
Glu Leu Thr Gly Thr Pro Phe Asp Val Glu Ser Asp Ser Phe Cys Leu
            1380                1385                1390        
Arg Asn Ile Met Glu Ala Pro Leu Leu Lys His Lys Asp Asp Ile Glu
        1395                1400                1405            
Asp Ile Cys Ile Ser Ala Ile Lys Glu Lys Asp Ile Glu Ala Lys Leu
    1410                1415                1420                
Thr Gln Val Ile Glu Asn Trp Thr Asn Gln Asn Leu Ser Phe Ala Ala
1425                1430                1435                1440
Phe Lys Gly Lys Gly Glu Leu Leu Leu Lys Gly Thr Glu Ser Gly Glu
                1445                1450                1455    
Ile Ile Thr Leu Met Glu Asp Ser Leu Met Val Leu Gly Ser Leu Leu
            1460                1465                1470        
Ser Asn Arg Tyr Asn Ala Pro Phe Lys Lys Asn Ile Gln Asn Trp Val
        1475                1480                1485            
Tyr Lys Leu Ser Thr Ser Ser Asp Ile Ile Glu Glu Trp Leu Val Val
    1490                1495                1500                
Gln Asn Leu Trp Val Tyr Leu Glu Ala Val Phe Val Gly Gly Asp Ile
1505                1510                1515                1520
Ala Lys Gln Leu Pro Gln Glu Ala Lys Arg Phe Gln Asn Ile Asp Lys
                1525                1530                1535    
Ser Trp Ile Lys Ile Met Gln Arg Ala His Glu Asn Pro Asn Val Ile
            1540                1545                1550        
Asn Cys Cys Val Gly Asp Glu Thr Met Gly Gln Leu Leu Pro His Leu
        1555                1560                1565            
His Glu Gln Leu Glu Val Cys Gln Lys Ser Leu Thr Gly Tyr Leu Glu
    1570                1575                1580                
Lys Lys Arg Leu Leu Phe Pro Arg Phe Phe Phe Val Ser Asp Pro Val
1585                1590                1595                1600
Leu Leu Glu Ile Leu Gly Gln Ala Ser Asp Ser His Thr Ile Gln Pro
                1605                1610                1615    
His Leu Pro Ala Val Ser Asp Asn Ile Asn Glu Val Thr Phe His Ala
            1620                1625                1630        
Lys Asp Tyr Asp Arg Ile Met Ala Val Ile Ser Arg Glu Gly Glu Lys
        1635                1640                1645            
Ile Val Leu Asp Asn Ser Val Met Ala Lys Gly Pro Val Glu Ile Trp
    1650                1655                1660                
Leu Leu Asp Leu Leu Lys Met Gln Met Ser Ser Leu His Asn Ile Ile
1665                1670                1675                1680
Arg Ser Ala Phe Tyr Gln Ile Ser Asp Ser Gly Phe Gln Leu Leu Pro
                1685                1690                1695    
Phe Leu Ser His Phe Pro Ala Gln Val Gly Leu Leu Gly Ile Gln Met
            1700                1705                1710        
Leu Trp Thr His Asp Ser Glu Glu Ala Leu Arg Asn Ala Lys Asp Asp
        1715                1720                1725            
Arg Lys Ile Met Gln Val Thr Asn Gln Lys Phe Leu Asp Ile Leu Asn
    1730                1735                1740                
Thr Leu Ile Ser Gln Thr Thr His Asp Leu Ser Lys Phe Asp Arg Val
1745                1750                1755                1760
Lys Phe Glu Thr Leu Ile Thr Ile His Val His Gln Arg Asp Ile Phe
                1765                1770                1775    
Asp Asp Leu Val Lys Met His Ile Lys Ser Pro Thr Asp Phe Glu Trp
            1780                1785                1790        
Leu Lys Gln Ser Arg Phe Tyr Phe Lys Glu Asp Leu Asp Gln Thr Val
        1795                1800                1805            
Val Ser Ile Thr Asp Val Asp Phe Ile Tyr Gln Asn Glu Phe Leu Gly
    1810                1815                1820                
Cys Thr Asp Arg Leu Val Ile Thr Pro Leu Thr Asp Arg Cys Tyr Ile
1825                1830                1835                1840
Thr Leu Ala Gln Ala Leu Gly Met Asn Met Gly Gly Ala Pro Ala Gly
                1845                1850                1855    
Pro Ala Gly Thr Gly Lys Thr Glu Thr Thr Lys Asp Met Gly Arg Cys
            1860                1865                1870        
Leu Gly Lys Tyr Val Val Val Phe Asn Cys Ser Asp Gln Met Asp Phe
        1875                1880                1885            
Arg Gly Leu Gly Arg Ile Phe Lys Gly Lys Cys Leu Ala Gln Ser Gly
    1890                1895                1900                
Ser Trp Gly Cys Phe Asp Glu Phe Asn Arg Ile Glu Leu Pro Val Leu
1905                1910                1915                1920
Ser Val Ala Ala Gln Gln Ile Tyr Ile Val Leu Thr Ala Arg Lys Glu
                1925                1930                1935    
Arg Lys Lys Gln Phe Ile Phe Ser Asp Gly Asp Cys Val Asp Leu Asn
            1940                1945                1950        
Pro Glu Phe Gly Ile Phe Leu Thr Met Asn Pro Gly Tyr Ala Gly Arg
        1955                1960                1965            
Gln Glu Leu Pro Glu Asn Leu Lys Ile Gln Phe Arg Thr Val Ala Met
    1970                1975                1980                
Met Val Pro Asp Arg Gln Ile Ile Met Arg Val Lys Leu Ala Ser Cys
1985                1990                1995                2000
Gly Phe Leu Glu Asn Val Ile Leu Ala Gln Lys Phe Tyr Val Leu Tyr
                2005                2010                2015    
Lys Leu Cys Glu Glu Gln Leu Thr Lys Gln Val His Tyr Asp Phe Gly
            2020                2025                2030        
Leu Arg Asn Ile Leu Ser Val Leu Arg Thr Leu Gly Ser Gln Lys Arg
        2035                2040                2045            
Ala Arg Pro Glu Asp Ser Glu Leu Ser Ile Val Met Arg Gly Leu Arg
    2050                2055                2060                
Asp Met Asn Leu Ser Lys Leu Val Asp Glu Asp Glu Pro Leu Phe Leu
2065                2070                2075                2080
Ser Leu Ile Asn Asp Leu Phe Pro Gly Leu Gln Leu Asp Ser Asn Thr
                2085                2090                2095    
Tyr Ala Glu Leu Gln Asn Ala Val Ala His Gln Val Gln Ile Glu Gly
            2100                2105                2110        
Leu Ile Asn His Pro Pro Trp Asn Leu Lys Leu Val Gln Leu Tyr Glu
        2115                2120                2125            
Thr Ser Leu Val Arg His Gly Leu Met Thr Leu Gly Pro Ser Gly Ser
    2130                2135                2140                
Gly Lys Thr Thr Val Ile Thr Ile Leu Met Lys Ala Gln Thr Glu Cys
2145                2150                2155                2160
Gly Arg Pro His Arg Glu Met Arg Met Asn Pro Lys Ala Ile Thr Ala
                2165                2170                2175    
Pro Gln Met Phe Gly Arg Leu Asp Thr Ala Thr Asn Asp Trp Thr Asp
            2180                2185                2190        
Gly Ile Phe Ser Thr Leu Trp Arg Lys Thr Leu Lys Ala Lys Lys Gly
        2195                2200                2205            
Glu Asn Ile Phe Leu Ile Leu Asp Gly Pro Val Asp Ala Ile Trp Ile
    2210                2215                2220                
Glu Asn Leu Asn Ser Val Leu Asp Asp Asn Lys Thr Leu Thr Leu Ala
2225                2230                2235                2240
Asn Gly Asp Arg Ile Pro Met Ala Pro Ser Cys Lys Leu Leu Phe Glu
                2245                2250                2255    
Val His Asn Ile Glu Asn Ala Ser Pro Ala Thr Val Ser Arg Met Gly
            2260                2265                2270        
Met Val Tyr Ile Ser Ser Ser Ala Leu Ser Trp Arg Pro Ile Leu Gln
        2275                2280                2285            
Ala Trp Leu Lys Lys Arg Thr Ala Gln Glu Ala Ala Val Phe Leu Thr
    2290                2295                2300                
Leu Tyr Glu Lys Val Phe Glu Asp Thr Tyr Thr Tyr Met Lys Leu Asn
2305                2310                2315                2320
Leu Asn Pro Lys Met Gln Leu Leu Glu Cys Asn Tyr Ile Val Gln Ser
                2325                2330                2335    
Leu Asn Leu Leu Glu Gly Leu Ile Pro Ser Lys Glu Glu Gly Gly Val
            2340                2345                2350        
Ser Cys Val Glu His Leu His Lys Leu Phe Val Phe Gly Leu Met Trp
        2355                2360                2365            
Ser Leu Gly Ala Leu Leu Glu Leu Glu Ser Arg Glu Lys Leu Glu Ala
    2370                2375                2380                
Phe Leu Arg Gln His Glu Ser Lys Leu Asp Leu Pro Glu Ile Pro Lys
2385                2390                2395                2400
Gly Ser Asn Gln Thr Met Tyr Glu Phe Tyr Val Thr Asp Tyr Gly Asp
                2405                2410                2415    
Trp Glu His Trp Asn Lys Lys Leu Gln Pro Tyr Tyr Tyr Pro Thr Asp
            2420                2425                2430        
Ser Ile Pro Glu Tyr Ser Ser Ile Leu Val Pro Asn Val Asp Asn Ile
        2435                2440                2445            
Arg Thr Asn Phe Leu Ile Asp Thr Ile Ala Lys Gln His Lys Ala Val
    2450                2455                2460                
Leu Leu Thr Gly Glu Gln Gly Thr Ala Lys Thr Val Met Val Lys Ala
2465                2470                2475                2480
Tyr Leu Lys Lys Tyr Asp Pro Glu Val Gln Leu Ser Lys Ser Leu Asn
                2485                2490                2495    
Phe Ser Ser Ala Thr Glu Pro Met Met Phe Gln Arg Thr Ile Glu Ser
            2500                2505                2510        
Tyr Val Asp Lys Arg Ile Gly Ser Thr Tyr Gly Pro Pro Gly Gly Arg
        2515                2520                2525            
Lys Met Thr Val Phe Ile Asp Asp Ile Asn Met Pro Val Ile Asn Glu
    2530                2535                2540                
Trp Gly Asp Gln Ile Thr Asn Glu Ile Val Arg Gln Met Met Glu Met
2545                2550                2555                2560
Glu Gly Met Tyr Ser Leu Asp Lys Pro Gly Asp Phe Thr Thr Ile Val
                2565                2570                2575    
Asp Val Gln Leu Ile Ala Ala Met Ile His Pro Gly Gly Gly Arg Asn
            2580                2585                2590        
Asp Ile Pro Gln Arg Leu Lys Arg Gln Phe Thr Val Phe Asn Cys Thr
        2595                2600                2605            
Leu Pro Ser Asn Ala Ser Ile Asp Lys Ile Phe Gly Ile Ile Gly Cys
    2610                2615                2620                
Gly Tyr Phe Asp Pro Cys Arg Ser Phe Lys Pro Gln Ile Cys Glu Met
2625                2630                2635                2640
Ile Val Asn Leu Val Ser Val Gly Arg Val Leu Trp Gln Trp Thr Lys
                2645                2650                2655    
Val Lys Met Leu Pro Thr Pro Ser Lys Phe His Tyr Ile Phe Asn Leu
            2660                2665                2670        
Arg Asp Leu Ser Arg Ile Trp Gln Gly Met Leu Thr Ile Lys Ala Glu
        2675                2680                2685            
Glu Cys Ala Ser Ile Pro Thr Leu Leu Ser Leu Phe Lys His Glu Cys
    2690                2695                2700                
Ser Arg Val Ile Ala Asp Arg Phe Ile Thr Pro Glu Asp Glu Gln Trp
2705                2710                2715                2720
Phe Asn Ala His Leu Thr Arg Ala Val Glu Glu Asn Ile Gly Ser Asp
                2725                2730                2735    
Ala Ala Ser Cys Ile Leu Pro Glu Pro Tyr Phe Val Asp Phe Leu Arg
            2740                2745                2750        
Glu Met Pro Glu Pro Thr Gly Asp Glu Pro Glu Asp Ser Val Phe Glu
        2755                2760                2765            
Val Pro Lys Ile Tyr Glu Leu Met Pro Ser Phe Asp Phe Leu Ala Glu
    2770                2775                2780                
Lys Leu Gln Phe Tyr Gln Arg Gln Phe Asn Glu Ile Ile Arg Gly Thr
2785                2790                2795                2800
Ser Leu Asp Leu Val Phe Phe Lys Asp Ala Met Thr His Leu Ile Lys
                2805                2810                2815    
Ile Ser Arg Ile Ile Arg Thr Ser Cys Gly Asn Ala Leu Leu Val Gly
            2820                2825                2830        
Val Gly Gly Ser Gly Lys Gln Ser Leu Ser Arg Leu Ala Ser Phe Ile
        2835                2840                2845            
Ala Gly Tyr Gln Ile Phe Gln Ile Thr Leu Thr Arg Ser Tyr Asn Val
    2850                2855                2860                
Thr Asn Leu Thr Asp Asp Leu Lys Ala Leu Tyr Lys Val Ala Gly Ala
2865                2870                2875                2880
Asp Gly Lys Gly Ile Thr Phe Ile Phe Thr Asp Ser Glu Ile Lys Asp
                2885                2890                2895    
Glu Ala Phe Leu Glu Tyr Leu Asn Asn Leu Leu Ser Ser Gly Glu Ile
            2900                2905                2910        
Ser Asn Leu Phe Ala Arg Asp Glu Met Asp Glu Ile Thr Gln Gly Leu
        2915                2920                2925            
Ile Ser Val Met Lys Arg Glu Leu Pro Arg His Pro Pro Thr Phe Asp
    2930                2935                2940                
Asn Leu Tyr Glu Tyr Phe Ile Ser Arg Ser Arg Lys Asn Leu His Val
2945                2950                2955                2960
Val Leu Cys Phe Ser Pro Val Gly Glu Lys Phe Arg Ala Arg Ser Leu
                2965                2970                2975    
Lys Phe Pro Gly Leu Ile Ser Gly Cys Thr Met Asp Trp Phe Ser Arg
            2980                2985                2990        
Trp Pro Arg Glu Ala Leu Ile Ala Val Ala Ser Tyr Phe Leu Ser Asp
        2995                3000                3005            
Tyr Asn Ile Val Cys Ser Ser Glu Ile Lys Arg Gln Val Val Glu Thr
    3010                3015                3020                
Met Gly Leu Phe His Asp Met Val Ser Glu Ser Cys Glu Ser Tyr Phe
3025                3030                3035                3040
Gln Arg Tyr Arg Arg Arg Ala His Val Thr Pro Lys Ser Tyr Leu Ser
                3045                3050                3055    
Phe Ile Asn Gly Tyr Lys Asn Ile Tyr Ala Glu Lys Val Lys Phe Ile
            3060                3065                3070        
Asn Glu Gln Ala Glu Arg Met Asn Ile Gly Leu Asp Lys Leu Met Glu
        3075                3080                3085            
Ala Ser Glu Ser Val Ala Lys Leu Ser Gln Asp Leu Ala Val Lys Glu
    3090                3095                3100                
Lys Glu Leu Ala Val Ala Ser Ile Lys Ala Asp Glu Val Leu Ala Glu
3105                3110                3115                3120
Val Thr Val Ser Ala Gln Ala Ser Ala Lys Ile Lys Asn Glu Val Gln
                3125                3130                3135    
Glu Val Lys Asp Lys Ala Gln Lys Ile Val Asp Glu Ile Asp Ser Glu
            3140                3145                3150        
Lys Val Lys Ala Glu Ser Lys Leu Glu Ala Ala Lys Pro Ala Leu Glu
        3155                3160                3165            
Glu Ala Glu Ala Ala Leu Asn Thr Ile Lys Pro Asn Asp Ile Ala Thr
    3170                3175                3180                
Val Arg Lys Leu Ala Lys Pro Pro His Leu Ile Met Arg Ile Met Asp
3185                3190                3195                3200
Cys Val Leu Leu Leu Phe Gln Lys Lys Ile Asp Pro Val Thr Met Asp
                3205                3210                3215    
Pro Glu Lys Ser Cys Cys Lys Pro Ser Trp Gly Glu Ser Leu Lys Leu
            3220                3225                3230        
Met Ser Ala Thr Gly Phe Leu Trp Ser Leu Gln Gln Phe Pro Lys Asp
        3235                3240                3245            
Thr Ile Asn Glu Glu Thr Val Glu Leu Leu Gln Pro Tyr Phe Asn Met
    3250                3255                3260                
Asp Asp Tyr Thr Phe Glu Ser Ala Lys Lys Val Cys Gly Asn Val Ala
3265                3270                3275                3280
Gly Leu Leu Ser Trp Thr Leu Ala Met Ala Ile Phe Tyr Gly Ile Asn
                3285                3290                3295    
Arg Glu Val Leu Pro Leu Lys Ala Asn Leu Ala Lys Gln Glu Gly Arg
            3300                3305                3310        
Leu Ala Val Ala Asn Ala Glu Leu Gly Lys Ala Gln Ala Leu Leu Asp
        3315                3320                3325            
Glu Lys Gln Ala Glu Leu Asp Lys Val Gln Ala Lys Phe Asp Ala Ala
    3330                3335                3340                
Met Asn Glu Lys Met Asp Leu Leu Asn Asp Ala Asp Thr Cys Arg Lys
3345                3350                3355                3360
Lys Met Gln Ala Ala Ser Thr Leu Ile Asp Gly Leu Ser Gly Glu Lys
                3365                3370                3375    
Ile Arg Trp Thr Gln Gln Ser Lys Glu Phe Lys Ala Gln Ile Asn Arg
            3380                3385                3390        
Leu Val Gly Asp Ile Leu Leu Cys Thr Gly Phe Leu Ser Tyr Leu Gly
        3395                3400                3405            
Pro Phe Asn Gln Ile Phe Arg Asn Tyr Leu Leu Lys Asp Gln Trp Glu
    3410                3415                3420                
Met Glu Leu Arg Ala Arg Lys Ile Pro Phe Thr Glu Asn Leu Asn Leu
3425                3430                3435                3440
Ile Ser Met Leu Val Asp Pro Pro Thr Ile Gly Glu Trp Gly Leu Gln
                3445                3450                3455    
Gly Leu Pro Gly Asp Asp Leu Ser Ile Gln Asn Gly Ile Ile Val Thr
            3460                3465                3470        
Lys Ala Thr Arg Tyr Pro Leu Leu Ile Asp Pro Gln Thr Gln Gly Lys
        3475                3480                3485            
Thr Trp Ile Lys Ser Lys Glu Lys Glu Asn Asp Leu Gln Val Thr Ser
    3490                3495                3500                
Leu Asn His Lys Tyr Phe Arg Thr His Leu Glu Asp Ser Leu Ser Leu
3505                3510                3515                3520
Gly Arg Pro Leu Leu Ile Glu Asp Ile His Glu Glu Leu Asp Pro Ala
                3525                3530                3535    
Leu Asp Asn Val Leu Glu Lys Asn Phe Ile Lys Ser Gly Thr Thr Phe
            3540                3545                3550        
Lys Val Lys Val Gly Asp Lys Glu Cys Asp Ile Met Asp Thr Phe Lys
        3555                3560                3565            
Leu Tyr Ile Thr Thr Lys Leu Pro Asn Pro Ala Phe Thr Pro Glu Ile
    3570                3575                3580                
Asn Ala Lys Thr Ser Val Ile Asp Phe Thr Val Thr Met Lys Gly Leu
3585                3590                3595                3600
Glu Asn Gln Leu Leu Arg Arg Val Ile Leu Thr Glu Lys Gln Glu Leu
                3605                3610                3615    
Glu Ala Glu Arg Val Lys Leu Leu Glu Asp Val Thr Phe Asn Lys Arg
            3620                3625                3630        
Lys Met Lys Glu Leu Glu Asp Asn Leu Leu Tyr Lys Leu Ser Ala Thr
        3635                3640                3645            
Lys Gly Ser Leu Val Asp Asp Glu Ser Leu Ile Gly Val Leu Arg Thr
    3650                3655                3660                
Thr Lys Gln Thr Ala Ala Glu Val Ser Glu Lys Leu His Val Ala Ala
3665                3670                3675                3680
Glu Thr Glu Ile Lys Ile Asn Ala Ala Gln Glu Glu Phe Arg Pro Ala
                3685                3690                3695    
Ala Thr Arg Gly Ser Ile Leu Tyr Phe Leu Ile Thr Glu Met Ser Met
            3700                3705                3710        
Val Asn Ile Met Tyr Gln Thr Ser Leu Ala Gln Phe Leu Lys Leu Phe
        3715                3720                3725            
Asp Gln Ser Met Ala Arg Ser Glu Lys Ser Pro Leu Pro Gln Lys Arg
    3730                3735                3740                
Ile Thr Asn Ile Ile Glu Tyr Leu Thr Tyr Glu Val Phe Thr Tyr Ser
3745                3750                3755                3760
Val Arg Gly Leu Tyr Glu Asn His Lys Phe Leu Phe Val Leu Leu Met
                3765                3770                3775    
Thr Leu Lys Ile Asp Leu Gln Arg Gly Thr Val Lys His Arg Glu Phe
            3780                3785                3790        
Gln Ala Leu Ile Lys Gly Gly Ala Ala Leu Asp Leu Lys Ala Cys Pro
        3795                3800                3805            
Pro Lys Pro Tyr Arg Trp Ile Leu Asp Met Thr Trp Leu Asn Leu Val
    3810                3815                3820                
Glu Leu Ser Lys Leu Pro Gln Phe Ala Glu Ile Met Asn Gln Ile Ser
3825                3830                3835                3840
Arg Asn Glu Lys Gly Trp Lys Ser Trp Phe Asp Lys Asp Ala Pro Glu
                3845                3850                3855    
Glu Glu Ile Ile Pro Asp Gly Tyr Asn Asp Ser Leu Asp Thr Cys His
            3860                3865                3870        
Lys Leu Leu Leu Ile Arg Ser Trp Cys Pro Asp Arg Thr Val Phe Gln
        3875                3880                3885            
Ala Arg Lys Tyr Ile Ala Asp Ser Leu Glu Glu Lys Tyr Thr Glu Pro
    3890                3895                3900                
Val Ile Leu Asn Leu Glu Lys Thr Trp Glu Glu Ser Asp Thr Arg Thr
3905                3910                3915                3920
Pro Leu Ile Cys Phe Leu Ser Met Gly Ser Asp Pro Thr Asn Gln Ile
                3925                3930                3935    
Asp Ala Leu Ala Lys Lys Leu Lys Leu Glu Cys Arg Thr Ile Ser Met
            3940                3945                3950        
Gly Gln Gly Gln Glu Val His Ala Arg Lys Leu Ile Gln Met Ser Met
        3955                3960                3965            
Gln Gln Gly Gly Trp Val Leu Leu Gln Asn Cys His Leu Gly Leu Glu
    3970                3975                3980                
Phe Met Glu Glu Leu Leu Glu Thr Leu Ile Thr Thr Glu Ala Ser Asp
3985                3990                3995                4000
Asp Ser Phe Arg Val Trp Ile Thr Thr Glu Pro His Asp Arg Phe Pro
                4005                4010                4015    
Ile Thr Leu Leu Gln Thr Ser Leu Lys Phe Thr Asn Glu Pro Pro Gln
            4020                4025                4030        
Gly Val Arg Ala Gly Leu Lys Arg Thr Phe Ala Gly Ile Asn Gln Asp
        4035                4040                4045            
Leu Leu Asp Ile Ser Asn Leu Pro Met Trp Lys Pro Met Leu Tyr Thr
    4050                4055                4060                
Val Ala Phe Leu His Ser Thr Val Gln Glu Arg Arg Lys Phe Gly Pro
4065                4070                4075                4080
Leu Gly Trp Asn Ile Pro Tyr Glu Phe Asn Ser Ala Asp Phe Ser Ala
                4085                4090                4095    
Ser Val Gln Phe Ile Gln Asn His Leu Asp Glu Cys Asp Ile Lys Lys
            4100                4105                4110        
Gly Val Ser Trp Asn Thr Val Arg Tyr Met Ile Gly Glu Val Gln Tyr
        4115                4120                4125            
Gly Gly Arg Val Thr Asp Asp Phe Asp Lys Arg Leu Leu Asn Cys Phe
    4130                4135                4140                
Ala Arg Val Trp Phe Ser Glu Lys Met Phe Glu Pro Ser Phe Cys Phe
4145                4150                4155                4160
Tyr Thr Gly Tyr Lys Ile Pro Leu Cys Lys Thr Leu Asp Gln Tyr Phe
                4165                4170                4175    
Glu Tyr Ile Gln Ser Leu Pro Ser Leu Asp Asn Pro Glu Val Phe Gly
            4180                4185                4190        
Leu His Pro Asn Ala Asp Ile Thr Tyr Gln Ser Asn Thr Ala Ser Ala
        4195                4200                4205            
Val Leu Glu Thr Ile Thr Asn Ile Gln Pro Lys Glu Ser Gly Gly Gly
    4210                4215                4220                
Val Gly Glu Thr Arg Glu Ala Ile Val Tyr Arg Leu Ser Glu Asp Met
4225                4230                4235                4240
Leu Ser Lys Leu Pro Pro Asp Tyr Ile Pro His Glu Val Lys Ser Arg
                4245                4250                4255    
Leu Ile Lys Met Gly His Leu Asn Ser Met Asn Ile Phe Leu Arg Gln
            4260                4265                4270        
Glu Ile Asp Arg Met Gln Arg Val Ile Ser Ile Leu Arg Ser Ser Leu
        4275                4280                4285            
Ser Asp Leu Lys Leu Ala Ile Glu Gly Thr Ile Ile Met Ser Glu Asn
    4290                4295                4300                
Leu Arg Asp Ala Leu Asp Asn Met Tyr Asp Ala Arg Ile Pro Gln Leu
4305                4310                4315                4320
Trp Lys Arg Val Ser Trp Asp Ser Ser Thr Leu Gly Phe Trp Phe Thr
                4325                4330                4335    
Glu Leu Leu Glu Arg Asn Ala Gln Phe Ser Thr Trp Ile Phe Glu Gly
            4340                4345                4350        
Arg Pro Asn Val Phe Trp Met Thr Gly Phe Phe Asn Pro Gln Gly Phe
        4355                4360                4365            
Leu Thr Ala Met Arg Gln Glu Val Thr Arg Ala His Lys Gly Trp Ala
    4370                4375                4380                
Leu Asp Thr Val Thr Ile His Asn Glu Val Leu Arg Gln Thr Lys Glu
4385                4390                4395                4400
Glu Ile Thr Ser Pro Pro Gly Glu Gly Val Tyr Ile Tyr Gly Leu Tyr
                4405                4410                4415    
Met Asp Gly Ala Ala Trp Asp Arg Arg Asn Gly Lys Leu Met Glu Ser
            4420                4425                4430        
Thr Pro Lys Val Leu Phe Thr Gln Leu Pro Val Leu His Ile Phe Ala
        4435                4440                4445            
Ile Asn Ser Thr Ala Pro Lys Asp Pro Lys Leu Tyr Val Cys Pro Ile
    4450                4455                4460                
Tyr Lys Lys Pro Arg Arg Thr Asp Leu Thr Phe Ile Thr Val Val Tyr
4465                4470                4475                4480
Leu Arg Thr Val Leu Ser Pro Asp His Trp Ile Leu Arg Gly Val Ala
                4485                4490                4495    
Leu Leu Cys Asp Ile Lys
            4500        


<210> 7825
<211> 872
<212> PRT
<213> Homo sapiens

<400> 7825
Met Gly Asn Arg Gly Met Glu Glu Leu Ile Pro Leu Val Asn Lys Leu
 1               5                  10                  15      
Gln Asp Ala Phe Ser Ser Ile Gly Gln Ser Cys His Leu Asp Leu Pro
            20                  25                  30          
Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu
        35                  40                  45              
Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val
    50                  55                  60                  
Thr Arg Arg Pro Leu Ile Leu Gln Leu Ile Phe Ser Lys Thr Glu His
65                  70                  75                  80  
Ala Glu Phe Leu His Cys Lys Ser Lys Lys Phe Thr Asp Phe Asp Glu
                85                  90                  95      
Val Arg Gln Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn
            100                 105                 110         
Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His
        115                 120                 125             
Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro
    130                 135                 140                 
Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Lys Asp Met Ile
145                 150                 155                 160 
Leu Gln Phe Ile Ser Arg Glu Ser Ser Leu Ile Leu Ala Val Thr Pro
                165                 170                 175     
Ala Asn Met Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu
            180                 185                 190         
Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp
        195                 200                 205             
Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu
    210                 215                 220                 
Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys
225                 230                 235                 240 
Asp Ile Glu Gly Lys Lys Asp Ile Arg Ala Ala Leu Ala Ala Glu Arg
                245                 250                 255     
Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Met Ala Asp Arg Met
            260                 265                 270         
Gly Thr Pro His Leu Gln Lys Thr Leu Asn Gln Gln Leu Thr Asn His
        275                 280                 285             
Ile Arg Glu Ser Leu Pro Ala Leu Arg Ser Lys Leu Gln Ser Gln Leu
    290                 295                 300                 
Leu Ser Leu Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp
305                 310                 315                 320 
Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe
                325                 330                 335     
Gly Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp
            340                 345                 350         
Thr Leu Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu
        355                 360                 365             
Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Asp Leu
    370                 375                 380                 
Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Val Arg Gln
385                 390                 395                 400 
Val Pro Arg Gly Glu Thr Gly Leu Phe Thr Pro Asp Leu Ala Phe Glu
                405                 410                 415     
Ala Ile Val Lys Lys Gln Val Val Lys Leu Lys Glu Pro Cys Leu Lys
            420                 425                 430         
Cys Val Asp Leu Val Ile Gln Glu Leu Ile Asn Thr Val Arg Gln Cys
        435                 440                 445             
Thr Ser Lys Leu Ser Ser Tyr Pro Arg Leu Arg Glu Glu Thr Glu Arg
    450                 455                 460                 
Ile Val Thr Thr Tyr Ile Arg Glu Arg Glu Gly Arg Thr Lys Asp Gln
465                 470                 475                 480 
Ile Leu Leu Leu Ile Asp Ile Glu Gln Ser Tyr Ile Asn Thr Asn His
                485                 490                 495     
Glu Asp Phe Ile Gly Phe Ala Asn Ala Gln Gln Arg Ser Thr Gln Leu
            500                 505                 510         
Asn Lys Lys Arg Ala Ile Pro Asn Gln Val Ile Arg Arg Gly Trp Leu
        515                 520                 525             
Thr Ile Asn Asn Ile Ser Leu Met Lys Gly Gly Ser Lys Glu Tyr Trp
    530                 535                 540                 
Phe Val Leu Thr Ala Glu Ser Leu Ser Trp Tyr Lys Asp Glu Glu Glu
545                 550                 555                 560 
Lys Glu Lys Lys Tyr Met Leu Pro Leu Asp Asn Leu Lys Ile Arg Asp
                565                 570                 575     
Val Glu Lys Gly Phe Met Ser Asn Lys His Val Phe Ala Ile Phe Asn
            580                 585                 590         
Thr Glu Gln Arg Asn Val Tyr Lys Asp Leu Arg Gln Ile Glu Leu Ala
        595                 600                 605             
Cys Asp Ser Gln Glu Asp Val Asp Ser Trp Lys Ala Ser Phe Leu Arg
    610                 615                 620                 
Ala Gly Val Tyr Pro Glu Lys Asp Gln Ala Glu Asn Glu Asp Gly Ala
625                 630                 635                 640 
Gln Glu Asn Thr Phe Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu
                645                 650                 655     
Thr Ile Arg Asn Leu Val Asp Ser Tyr Val Ala Ile Ile Asn Lys Ser
            660                 665                 670         
Ile Arg Asp Leu Met Pro Lys Thr Ile Met His Leu Met Ile Asn Asn
        675                 680                 685             
Thr Lys Ala Phe Ile His His Glu Leu Leu Ala Tyr Leu Tyr Ser Ser
    690                 695                 700                 
Ala Asp Gln Ser Ser Leu Met Glu Glu Ser Ala Asp Gln Ala Gln Arg
705                 710                 715                 720 
Arg Asp Asp Met Leu Arg Met Tyr His Ala Leu Lys Glu Ala Leu Asn
                725                 730                 735     
Ile Ile Gly Asp Ile Ser Thr Ser Thr Val Ser Thr Pro Val Pro Pro
            740                 745                 750         
Pro Val Asp Asp Thr Trp Leu Gln Ser Ala Ser Ser His Ser Pro Thr
        755                 760                 765             
Pro Gln Arg Arg Pro Val Ser Ser Ile His Pro Pro Gly Arg Pro Pro
    770                 775                 780                 
Ala Val Arg Gly Pro Thr Pro Gly Pro Pro Leu Ile Pro Val Pro Val
785                 790                 795                 800 
Gly Ala Ala Ala Ser Phe Ser Ala Pro Pro Ile Pro Ser Arg Pro Gly
                805                 810                 815     
Pro Gln Ser Val Phe Ala Asn Ser Asp Leu Phe Pro Ala Pro Pro Gln
            820                 825                 830         
Ile Pro Ser Arg Pro Val Arg Ile Pro Pro Gly Ile Pro Pro Gly Val
        835                 840                 845             
Pro Ser Arg Arg Pro Pro Ala Ala Pro Ser Arg Pro Thr Ile Ile Arg
    850                 855                 860                 
Pro Ala Glu Pro Ser Leu Leu Asp
865                 870         


<210> 7826
<211> 464
<212> PRT
<213> Homo sapiens

<400> 7826
Met Ala Phe Glu Ala Ile Val Lys Lys Gln Ile Val Lys Leu Lys Glu
 1               5                  10                  15      
Pro Ser Leu Lys Cys Val Asp Leu Val Val Ser Glu Leu Ala Thr Val
            20                  25                  30          
Ile Lys Lys Cys Ala Glu Lys Leu Ser Ser Tyr Pro Arg Leu Arg Glu
        35                  40                  45              
Glu Thr Glu Arg Ile Val Thr Thr Tyr Ile Arg Glu Arg Glu Gly Arg
    50                  55                  60                  
Thr Lys Asp Gln Ile Leu Leu Leu Ile Asp Ile Glu Gln Ser Tyr Ile
65                  70                  75                  80  
Asn Thr Asn His Glu Asp Phe Ile Gly Phe Ala Asn Ala Gln Gln Arg
                85                  90                  95      
Ser Thr Gln Leu Asn Lys Lys Arg Ala Ile Pro Asn Gln Gly Glu Ile
            100                 105                 110         
Leu Val Ile Arg Arg Gly Trp Leu Thr Ile Asn Asn Ile Ser Leu Met
        115                 120                 125             
Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val Leu Thr Ala Glu Ser Leu
    130                 135                 140                 
Ser Trp Tyr Lys Asp Glu Glu Glu Lys Glu Lys Lys Tyr Met Leu Pro
145                 150                 155                 160 
Leu Asp Asn Leu Lys Ile Arg Asp Val Glu Lys Gly Phe Met Ser Asn
                165                 170                 175     
Lys His Val Phe Ala Ile Phe Asn Thr Glu Gln Arg Asn Val Tyr Lys
            180                 185                 190         
Asp Leu Arg Gln Ile Glu Leu Ala Cys Asp Ser Gln Glu Asp Val Asp
        195                 200                 205             
Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly Val Tyr Pro Glu Lys Asp
    210                 215                 220                 
Gln Ala Glu Asn Glu Asp Gly Ala Gln Glu Asn Thr Phe Ser Met Asp
225                 230                 235                 240 
Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser
                245                 250                 255     
Tyr Val Ala Ile Ile Asn Lys Ser Ile Arg Asp Leu Met Pro Lys Thr
            260                 265                 270         
Ile Met His Leu Met Ile Asn Asn Thr Lys Ala Phe Ile His His Glu
        275                 280                 285             
Leu Leu Ala Tyr Leu Tyr Ser Ser Ala Asp Gln Ser Ser Leu Met Glu
    290                 295                 300                 
Glu Ser Ala Asp Gln Ala Gln Arg Arg Asp Asp Met Leu Arg Met Tyr
305                 310                 315                 320 
His Ala Leu Lys Glu Ala Leu Asn Ile Ile Gly Asp Ile Ser Thr Ser
                325                 330                 335     
Thr Val Ser Thr Pro Val Pro Pro Pro Val Asp Asp Thr Trp Leu Gln
            340                 345                 350         
Ser Ala Ser Ser His Ser Pro Thr Pro Gln Arg Arg Pro Val Ser Ser
        355                 360                 365             
Ile His Pro Pro Gly Arg Pro Pro Ala Val Arg Gly Pro Thr Pro Gly
    370                 375                 380                 
Pro Pro Leu Ile Pro Val Pro Val Gly Ala Ala Ala Ser Phe Ser Ala
385                 390                 395                 400 
Pro Pro Ile Pro Ser Arg Pro Gly Pro Gln Ser Val Phe Ala Asn Ser
                405                 410                 415     
Asp Leu Phe Pro Ala Pro Pro Gln Ile Pro Ser Arg Pro Val Arg Ile
            420                 425                 430         
Pro Pro Gly Ile Pro Pro Gly Val Pro Ser Arg Arg Pro Pro Ala Ala
        435                 440                 445             
Pro Ser Arg Pro Thr Ile Ile Arg Pro Ala Glu Pro Ser Leu Leu Asp
    450                 455                 460                 


<210> 7827
<211> 870
<212> PRT
<213> Homo sapiens

<400> 7827
Met Gly Asn Arg Gly Met Glu Glu Leu Ile Pro Leu Val Asn Lys Leu
 1               5                  10                  15      
Gln Asp Ala Phe Ser Ser Ile Gly Gln Ser Cys His Leu Asp Leu Pro
            20                  25                  30          
Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu
        35                  40                  45              
Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val
    50                  55                  60                  
Thr Arg Arg Pro Leu Ile Leu Gln Leu Ile Phe Ser Lys Thr Glu His
65                  70                  75                  80  
Ala Glu Phe Leu His Cys Lys Ser Lys Lys Phe Thr Asp Phe Asp Glu
                85                  90                  95      
Val Arg Gln Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn
            100                 105                 110         
Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His
        115                 120                 125             
Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro
    130                 135                 140                 
Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Arg Val Lys Asp Met Ile
145                 150                 155                 160 
Leu Gln Phe Ile Ser Arg Glu Ser Ser Leu Ile Leu Ala Val Thr Pro
                165                 170                 175     
Ala Asn Met Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu
            180                 185                 190         
Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp
        195                 200                 205             
Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu
    210                 215                 220                 
Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys
225                 230                 235                 240 
Asp Ile Glu Gly Lys Lys Asp Ile Arg Ala Ala Leu Ala Ala Glu Arg
                245                 250                 255     
Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Met Ala Asp Arg Met
            260                 265                 270         
Gly Thr Pro His Leu Gln Lys Thr Leu Asn Gln Gln Leu Thr Asn His
        275                 280                 285             
Ile Arg Glu Ser Leu Pro Ala Leu Arg Ser Lys Leu Gln Ser Gln Leu
    290                 295                 300                 
Leu Ser Leu Glu Lys Glu Val Glu Glu Tyr Lys Ile Phe Arg Pro Asp
305                 310                 315                 320 
Asp Pro Thr Pro Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe
                325                 330                 335     
Gly Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp
            340                 345                 350         
Thr Leu Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu
        355                 360                 365             
Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Asp Leu
    370                 375                 380                 
Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Val Arg Thr
385                 390                 395                 400 
Gly Leu Phe Thr Pro Asp Leu Ala Phe Glu Ala Ile Val Lys Lys Gln
                405                 410                 415     
Val Val Lys Leu Lys Glu Pro Cys Leu Lys Cys Val Asp Leu Val Ile
            420                 425                 430         
Gln Glu Leu Ile Asn Thr Val Arg Gln Cys Thr Ser Lys Leu Ser Ser
        435                 440                 445             
Tyr Pro Arg Leu Arg Glu Glu Thr Glu Arg Ile Val Thr Thr Tyr Ile
    450                 455                 460                 
Arg Glu Arg Glu Gly Arg Thr Lys Asp Gln Ile Leu Leu Leu Ile Asp
465                 470                 475                 480 
Ile Glu Gln Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe
                485                 490                 495     
Ala Asn Ala Gln Gln Arg Ser Thr Gln Leu Asn Lys Lys Arg Ala Ile
            500                 505                 510         
Pro Asn Gln Gly Glu Ile Leu Val Ile Arg Arg Gly Trp Leu Thr Ile
        515                 520                 525             
Asn Asn Ile Ser Leu Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val
    530                 535                 540                 
Leu Thr Ala Glu Ser Leu Ser Trp Tyr Lys Asp Glu Glu Glu Lys Glu
545                 550                 555                 560 
Lys Lys Tyr Met Leu Pro Leu Asp Asn Leu Lys Ile Arg Asp Val Glu
                565                 570                 575     
Lys Gly Phe Met Ser Asn Lys His Val Phe Ala Ile Phe Asn Thr Glu
            580                 585                 590         
Gln Arg Asn Val Tyr Lys Asp Leu Arg Gln Ile Glu Leu Ala Cys Asp
        595                 600                 605             
Ser Gln Glu Asp Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly
    610                 615                 620                 
Val Tyr Pro Glu Lys Asp Gln Ala Glu Asn Glu Asp Gly Ala Gln Glu
625                 630                 635                 640 
Asn Thr Phe Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile
                645                 650                 655     
Arg Asn Leu Val Asp Ser Tyr Val Ala Ile Ile Asn Lys Ser Ile Arg
            660                 665                 670         
Asp Leu Met Pro Lys Thr Ile Met His Leu Met Ile Asn Asn Thr Lys
        675                 680                 685             
Ala Phe Ile His His Glu Leu Leu Ala Tyr Leu Tyr Ser Ser Ala Asp
    690                 695                 700                 
Gln Ser Ser Leu Met Glu Glu Ser Ala Asp Gln Ala Gln Arg Arg Asp
705                 710                 715                 720 
Asp Met Leu Arg Met Tyr His Ala Leu Lys Glu Ala Leu Asn Ile Ile
                725                 730                 735     
Gly Asp Ile Ser Thr Ser Thr Val Ser Thr Pro Val Pro Pro Pro Val
            740                 745                 750         
Asp Asp Thr Trp Leu Gln Ser Ala Ser Ser His Ser Pro Thr Pro Gln
        755                 760                 765             
Arg Arg Pro Val Ser Ser Ile His Pro Pro Gly Arg Pro Pro Ala Val
    770                 775                 780                 
Arg Gly Pro Thr Pro Gly Pro Pro Leu Ile Pro Val Pro Val Gly Ala
785                 790                 795                 800 
Ala Ala Ser Phe Ser Ala Pro Pro Ile Pro Ser Arg Pro Gly Pro Gln
                805                 810                 815     
Ser Val Phe Ala Asn Ser Asp Leu Phe Pro Ala Pro Pro Gln Ile Pro
            820                 825                 830         
Ser Arg Pro Val Arg Ile Pro Pro Gly Ile Pro Pro Gly Val Pro Ser
        835                 840                 845             
Arg Arg Pro Pro Ala Ala Pro Ser Arg Pro Thr Ile Ile Arg Pro Ala
    850                 855                 860                 
Glu Pro Ser Leu Leu Asp
865                 870 


<210> 7828
<211> 608
<212> PRT
<213> Homo sapiens

<400> 7828
Met Ser Gln Leu Pro Ser Thr Thr Arg Leu Glu Leu Gln Val Glu Leu
 1               5                  10                  15      
Asn Leu Asp Arg Pro Thr Pro Val His Leu Pro Val Pro Leu Tyr Glu
            20                  25                  30          
Gly Gly Gly Glu Ala Cys Leu Glu Glu Arg Glu Arg Leu Leu Gly Ala
        35                  40                  45              
Ser Gly Val Arg Arg Leu Ala Leu Ser Val Phe Thr Ser Pro Ser Gly
    50                  55                  60                  
Lys Leu Asp His Leu Arg Ser Arg Pro Ser Pro Ser Ser Pro His Ala
65                  70                  75                  80  
Gly Ser Phe Phe Leu Asn Gly Ser Arg Thr Glu Ala Ser His Lys Met
                85                  90                  95      
Ile Leu Leu Asn Asn Ser Gln Lys Leu Leu Val Leu Tyr Lys Pro Leu
            100                 105                 110         
Ala Trp Ser Ile Pro Glu Ser Leu Lys Val Tyr Gly Ser Val Tyr His
        115                 120                 125             
Ile Asn His Arg Asn Pro Phe Asn Met Glu Val Leu Val Asp Ser Trp
    130                 135                 140                 
Pro Glu Tyr Gln Met Val Ile Ile Gln Pro Gln Lys Gln Ser Phe Phe
145                 150                 155                 160 
Leu Lys Gly Ser Arg Thr Glu Ala Ser His Lys Met Ile Leu Leu Asn
                165                 170                 175     
Asn Ser Glu Gln Leu Leu Ala Leu Phe Lys Ser Leu Ala Arg Ser Ile
            180                 185                 190         
Pro Glu Ser Leu Lys Val Tyr Gly Ser Leu Phe His Ile Asn His Gly
        195                 200                 205             
Asn Pro Phe Asn Met Glu Val Leu Val Asp Ser Trp Pro Gly Tyr Gln
    210                 215                 220                 
Met Val Ile Ile Arg Pro Gln Lys Gln Glu Met Thr Asp Asp Met Asp
225                 230                 235                 240 
Ser Tyr Thr Asn Val Tyr Arg Ile Phe Ser Lys Asp Pro Gln Lys Ser
                245                 250                 255     
Gln Glu Val Leu Lys Asn Ser Glu Ile Ile Asn Trp Lys Gln Lys Leu
            260                 265                 270         
Gln Ile Gln Gly Phe Gln Glu Ser Leu Gly Glu Gly Ile Lys Ala Ala
        275                 280                 285             
Ala Phe Ser Asn Ser Val Lys Val Glu His Ser Arg Ala Leu Leu Phe
    290                 295                 300                 
Val Thr Glu Asp Ile Leu Lys Leu Tyr Ala Thr Asn Lys Ser Lys Leu
305                 310                 315                 320 
Gly Ser Trp Ala Glu Thr Gly His Pro Asp Asp Glu Leu Glu Ser Glu
                325                 330                 335     
Thr Pro Asn Phe Lys Tyr Ala Gln Leu Asn Val Ser Tyr Ser Gly Leu
            340                 345                 350         
Val Asn Asp Asn Trp Lys Leu Gly Met Asn Lys Arg Ser Leu His Tyr
        355                 360                 365             
Ile Lys Arg Cys Leu Gly Ala Leu Pro Ala Val Cys Met Leu Gly Pro
    370                 375                 380                 
Glu Gly Val Pro Val Ser Trp Val Thr Met Asp Pro Ser Cys Glu Ile
385                 390                 395                 400 
Gly Met Gly Tyr Ser Val Glu Lys Tyr Arg Arg Arg Gly Asn Ala Thr
                405                 410                 415     
Arg Met Met Ile Gln Met Ser Val Leu Ser Asp Thr Lys Cys Phe Tyr
            420                 425                 430         
Ser Ser Thr Val Gln Pro Pro Glu Pro Asp Val Leu Val Pro Arg Val
        435                 440                 445             
Leu Val Pro Gly Gln Ile Pro Gly Asp Phe Thr Gln Thr Arg Val Gln
    450                 455                 460                 
Pro Ala Leu Gly Leu Glu Val Arg Trp Ser Leu Ser Leu Cys Ile Ile
465                 470                 475                 480 
Arg Val Glu Leu Ser Leu Leu Leu Pro Lys Asp Pro Ala Trp Met Leu
                485                 490                 495     
Ile Pro Pro Pro Ser Pro Thr Pro Gln Leu Gln Asn Gly Ser Asn Cys
            500                 505                 510         
His Thr Pro Lys Gln Leu Gly Trp Leu Phe Ala Leu Gln Leu Pro Pro
        515                 520                 525             
Ala Arg Cys Pro Ser Trp Gln Ser Lys Val Trp Glu Ser Ala Lys Ala
    530                 535                 540                 
Pro Arg Ala Ser His Ser Ala Gln Leu Pro Arg Ser Ser Ser Leu Ala
545                 550                 555                 560 
Ser Thr Gly Arg Gln Gly Thr Pro Met Arg Arg Lys Glu Gln Gly Ser
                565                 570                 575     
Asp Cys Leu Val Tyr Pro Gly Thr Arg Glu Leu Ser Pro Trp Thr Glu
            580                 585                 590         
Trp Arg Gly Glu Gly Ile Thr Glu Thr Gly Lys Gly His Pro Asp Lys
        595                 600                 605             


<210> 7829
<211> 637
<212> PRT
<213> Homo sapiens

<400> 7829
Met Ala Gly Gly Ala Gly Trp Ser Gly Ala Pro Ala Ala Leu Leu Arg
 1               5                  10                  15      
Ser Val Arg Arg Leu Arg Glu Val Phe Glu Val Cys Gly Arg Asp Pro
            20                  25                  30          
Asp Gly Phe Leu Arg Val Glu Arg Val Ala Ala Leu Gly Leu Arg Phe
        35                  40                  45              
Gly Gln Gly Glu Glu Val Glu Lys Leu Val Lys Tyr Leu Asp Pro Asn
    50                  55                  60                  
Asp Leu Gly Arg Ile Asn Phe Lys Asp Phe Cys Arg Gly Val Phe Ala
65                  70                  75                  80  
Met Lys Gly Cys Glu Glu Leu Leu Lys Asp Val Leu Ser Val Glu Ser
                85                  90                  95      
Ala Gly Thr Leu Pro Cys Ala Pro Glu Ile Pro Asp Cys Val Glu Gln
            100                 105                 110         
Gly Ser Glu Val Thr Gly Pro Thr Phe Ala Asp Gly Glu Leu Ile Pro
        115                 120                 125             
Arg Glu Pro Gly Phe Phe Pro Glu Asp Glu Glu Glu Ala Met Thr Leu
    130                 135                 140                 
Ala Pro Pro Glu Gly Pro Gln Glu Leu Tyr Thr Asp Ser Pro Met Glu
145                 150                 155                 160 
Ser Thr Gln Ser Leu Glu Gly Ser Val Gly Ser Pro Ala Glu Lys Asp
                165                 170                 175     
Gly Gly Leu Gly Gly Leu Phe Leu Pro Glu Asp Lys Ser Leu Val His
            180                 185                 190         
Thr Pro Ser Met Thr Thr Ser Asp Leu Ser Thr His Ser Thr Thr Ser
        195                 200                 205             
Leu Ile Ser Asn Glu Glu Gln Phe Glu Asp Tyr Gly Glu Gly Asp Asp
    210                 215                 220                 
Val Asp Cys Ala Pro Ser Ser Pro Cys Pro Asp Asp Glu Thr Arg Thr
225                 230                 235                 240 
Asn Val Tyr Ser Asp Leu Gly Ser Ser Val Ser Ser Ser Ala Gly Gln
                245                 250                 255     
Thr Pro Arg Lys Met Arg His Val Tyr Asn Ser Glu Leu Leu Asp Val
            260                 265                 270         
Tyr Cys Ser Gln Cys Cys Lys Lys Ile Asn Leu Leu Asn Asp Leu Glu
        275                 280                 285             
Ala Arg Leu Lys Asn Leu Lys Ala Asn Ser Pro Asn Arg Lys Ile Ser
    290                 295                 300                 
Ser Thr Ala Phe Gly Arg Gln Leu Met His Ser Ser Asn Phe Ser Ser
305                 310                 315                 320 
Ser Asn Gly Ser Thr Glu Asp Leu Phe Arg Asp Ser Ile Asp Ser Cys
                325                 330                 335     
Asp Asn Asp Ile Thr Glu Lys Val Ser Phe Leu Glu Lys Lys Val Thr
            340                 345                 350         
Glu Leu Glu Asn Asp Ser Leu Thr Asn Gly Asp Leu Lys Ser Lys Leu
        355                 360                 365             
Lys Gln Glu Asn Thr Gln Leu Val His Arg Val His Glu Leu Glu Glu
    370                 375                 380                 
Met Val Lys Asp Gln Glu Thr Thr Ala Glu Gln Ala Leu Glu Glu Glu
385                 390                 395                 400 
Ala Arg Arg His Arg Glu Ala Tyr Gly Lys Leu Glu Arg Glu Lys Ala
                405                 410                 415     
Thr Glu Val Glu Leu Leu Asn Ala Arg Val Gln Gln Leu Glu Glu Glu
            420                 425                 430         
Asn Thr Glu Leu Arg Thr Thr Val Thr Arg Leu Lys Ser Gln Thr Glu
        435                 440                 445             
Lys Leu Asp Glu Glu Arg Gln Arg Met Ser Asp Arg Leu Glu Asp Thr
    450                 455                 460                 
Ser Leu Arg Leu Lys Asp Glu Met Asp Leu Tyr Lys Arg Met Met Asp
465                 470                 475                 480 
Lys Leu Arg Gln Asn Arg Leu Glu Phe Gln Lys Glu Arg Glu Ala Thr
                485                 490                 495     
Gln Glu Leu Ile Glu Asp Leu Arg Lys Glu Leu Glu His Leu Gln Met
            500                 505                 510         
Tyr Lys Leu Asp Cys Glu Arg Pro Gly Arg Gly Arg Ser Ala Ser Ser
        515                 520                 525             
Gly Leu Gly Glu Phe Asn Ala Arg Ala Arg Glu Val Glu Leu Glu His
    530                 535                 540                 
Glu Val Lys Arg Leu Lys Gln Glu Asn Tyr Lys Leu Arg Asp Gln Asn
545                 550                 555                 560 
Asp Asp Leu Asn Gly Gln Ile Leu Ser Leu Ser Leu Tyr Glu Ala Lys
                565                 570                 575     
Asn Leu Phe Ala Ala Gln Thr Lys Ala Gln Ser Leu Ala Ala Glu Ile
            580                 585                 590         
Asp Thr Ala Ser Arg Asp Glu Leu Met Glu Ala Leu Lys Glu Gln Glu
        595                 600                 605             
Glu Ile Asn Phe Arg Leu Arg Gln Tyr Met Asp Lys Ile Ile Leu Ala
    610                 615                 620                 
Ile Leu Asp His Asn Pro Ser Ile Leu Glu Ile Lys His
625                 630                 635         


<210> 7830
<211> 295
<212> PRT
<213> Homo sapiens

<400> 7830
Met Trp Arg Ser Cys Leu Arg Leu Arg Asp Gly Gly Arg Arg Leu Leu
 1               5                  10                  15      
Asn Arg Pro Ala Gly Gly Pro Ser Ala Ser Met Ser Pro Gly Pro Thr
            20                  25                  30          
Ile Pro Ser Pro Ala Arg Ala Tyr Ala Pro Pro Thr Glu Arg Lys Arg
        35                  40                  45              
Phe Tyr Gln Asn Val Ser Ile Thr Gln Gly Glu Gly Gly Phe Glu Ile
    50                  55                  60                  
Asn Leu Asp His Arg Lys Leu Lys Thr Pro Gln Ala Lys Leu Phe Thr
65                  70                  75                  80  
Val Pro Ser Glu Ala Leu Ala Ile Ala Val Ala Thr Glu Trp Asp Ser
                85                  90                  95      
Gln Gln Asp Thr Ile Lys Tyr Tyr Thr Met His Leu Thr Thr Leu Cys
            100                 105                 110         
Asn Thr Ser Leu Asp Asn Pro Thr Gln Arg Asn Lys Asp Gln Leu Ile
        115                 120                 125             
Arg Ala Ala Val Lys Phe Leu Asp Thr Asp Thr Ile Cys Tyr Arg Val
    130                 135                 140                 
Glu Glu Pro Glu Thr Leu Val Glu Leu Gln Arg Asn Glu Trp Asp Pro
145                 150                 155                 160 
Ile Ile Glu Trp Ala Glu Lys Arg Tyr Gly Val Glu Ile Ser Ser Ser
                165                 170                 175     
Thr Ser Ile Met Gly Pro Ser Ile Pro Ala Lys Thr Arg Glu Val Leu
            180                 185                 190         
Val Ser His Leu Ala Ser Tyr Asn Thr Trp Ala Leu Gln Gly Met Tyr
        195                 200                 205             
Gly Val Ser Trp Ile Glu Phe Val Ala Ala Gln Leu Lys Ser Met Val
    210                 215                 220                 
Leu Thr Leu Gly Leu Ile Asp Leu Arg Leu Thr Val Glu Gln Ala Val
225                 230                 235                 240 
Leu Leu Ser Arg Leu Glu Glu Glu Tyr Gln Ile Gln Lys Trp Gly Asn
                245                 250                 255     
Ile Glu Trp Ala His Asp Tyr Glu Leu Gln Glu Leu Arg Ala Arg Thr
            260                 265                 270         
Ala Ala Gly Thr Leu Phe Ile His Leu Cys Ser Glu Ser Thr Thr Val
        275                 280                 285             
Lys His Lys Leu Leu Lys Glu
    290                 295 


<210> 7831
<211> 136
<212> PRT
<213> Homo sapiens

<400> 7831
Met Lys Ile Gly Lys Gly Ser Val Phe Ser Asp Ala Phe Ser Pro Pro
 1               5                  10                  15      
Val Ser Leu Ala Ala Leu Glu Leu Ser Thr Gln Arg Gly Lys Gln Pro
            20                  25                  30          
Gln Tyr Asn Lys Val Leu Cys His Gly Ser Leu Glu Phe Gln Cys Pro
        35                  40                  45              
Leu Leu Leu Leu Leu Pro Val Ala Pro Ile Cys Val Leu Ser Cys Gly
    50                  55                  60                  
Ile Gly Phe Asp Ala Glu Met Gly Tyr Leu Cys Thr His Gln Leu Leu
65                  70                  75                  80  
Phe Leu Gln Leu Asn Gln Ser Ser Phe Asn Ser Lys Asn Gln Tyr Ala
                85                  90                  95      
Lys Lys Arg Arg Lys Arg Trp Asn His Gln Ala Leu Leu Gly Ser Glu
            100                 105                 110         
Tyr Val Cys Val Ser Ala His Thr Gln Val His Ala Ala Leu Gln Tyr
        115                 120                 125             
Lys Ile Lys Leu Tyr Asn Val Leu
    130                 135     


<210> 7832
<211> 600
<212> PRT
<213> Homo sapiens

<400> 7832
Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln
 1               5                  10                  15      
Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr
            20                  25                  30          
Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr
        35                  40                  45              
Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr
    50                  55                  60                  
Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro
65                  70                  75                  80  
Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly
                85                  90                  95      
Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr
            100                 105                 110         
Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly
        115                 120                 125             
Gln Gln Pro Ala Ala Thr Ala Pro Thr Ser Tyr Ser Ser Thr Gln Pro
    130                 135                 140                 
Thr Ser Tyr Asp Gln Ser Ser Tyr Ser Gln Gln Asn Thr Tyr Gly Gln
145                 150                 155                 160 
Pro Ser Ser Tyr Gly Gln Gln Gly Ser Tyr Gly Gln Gln Ser Ser Tyr
                165                 170                 175     
Gly Gln Gln Pro Pro Thr Ser Tyr Pro Pro Gln Thr Gly Ser Tyr Ser
            180                 185                 190         
Gln Ala Pro Ser Gln Tyr Ser Gln Gln Ser Ser Ser Tyr Gly Gln Gln
        195                 200                 205             
Ser Ser Phe Arg Gln Asp His Pro Ser Ser Met Gly Val Tyr Gly Gln
    210                 215                 220                 
Glu Ser Gly Gly Phe Ser Gly Pro Gly Glu Asn Arg Ser Met Ser Gly
225                 230                 235                 240 
Pro Asp Asn Arg Gly Arg Gly Arg Gly Gly Phe Asp Arg Gly Gly Met
                245                 250                 255     
Ser Arg Gly Gly Arg Gly Gly Gly Arg Gly Gly Met Gly Ser Ala Gly
            260                 265                 270         
Glu Arg Gly Gly Phe Asn Lys Pro Gly Gly Pro Met Asp Glu Gly Pro
        275                 280                 285             
Asp Leu Asp Leu Gly Pro Pro Val Asp Pro Asp Glu Asp Ser Asp Asn
    290                 295                 300                 
Ser Ala Ile Tyr Val Gln Gly Leu Asn Asp Ser Val Thr Leu Asp Asp
305                 310                 315                 320 
Leu Ala Asp Phe Phe Lys Gln Cys Gly Val Val Lys Met Asn Lys Arg
                325                 330                 335     
Thr Gly Gln Pro Met Ile His Ile Tyr Leu Asp Lys Glu Thr Gly Lys
            340                 345                 350         
Pro Lys Gly Asp Ala Thr Val Ser Tyr Glu Asp Pro Pro Thr Ala Lys
        355                 360                 365             
Ala Ala Val Glu Trp Phe Asp Gly Lys Asp Phe Gln Gly Ser Lys Leu
    370                 375                 380                 
Lys Val Ser Leu Ala Arg Lys Lys Pro Pro Met Asn Ser Met Arg Gly
385                 390                 395                 400 
Gly Leu Pro Pro Arg Glu Gly Arg Gly Met Pro Pro Pro Leu Arg Gly
                405                 410                 415     
Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro Met Gly Arg Met Gly
            420                 425                 430         
Gly Arg Gly Gly Asp Arg Gly Gly Phe Pro Pro Arg Gly Pro Arg Gly
        435                 440                 445             
Ser Arg Gly Asn Pro Ser Gly Gly Gly Asn Val Gln His Arg Ala Gly
    450                 455                 460                 
Asp Trp Gln Cys Pro Asn Pro Gly Cys Gly Asn Gln Asn Phe Ala Trp
465                 470                 475                 480 
Arg Thr Glu Cys Asn Gln Cys Lys Ala Pro Lys Pro Glu Gly Phe Leu
                485                 490                 495     
Pro Pro Pro Phe Pro Pro Pro Gly Gly Asp Arg Gly Arg Gly Gly Pro
            500                 505                 510         
Gly Gly Met Arg Gly Gly Arg Gly Gly Leu Met Asp Arg Gly Gly Pro
        515                 520                 525             
Gly Gly Met Phe Arg Gly Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg
    530                 535                 540                 
Gly Gly Arg Gly Met Asp Arg Gly Gly Phe Gly Gly Gly Arg Arg Gly
545                 550                 555                 560 
Gly Pro Gly Gly Pro Pro Gly Pro Leu Met Glu Gln Met Gly Gly Arg
                565                 570                 575     
Arg Gly Gly Arg Gly Gly Pro Gly Lys Met Asp Lys Gly Glu His Arg
            580                 585                 590         
Gln Glu Arg Arg Asp Arg Pro Tyr
        595                 600 


<210> 7833
<211> 354
<212> PRT
<213> Homo sapiens

<400> 7833
Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln
 1               5                  10                  15      
Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr
            20                  25                  30          
Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr
        35                  40                  45              
Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr
    50                  55                  60                  
Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro
65                  70                  75                  80  
Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly
                85                  90                  95      
Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr
            100                 105                 110         
Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly
        115                 120                 125             
Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys
    130                 135                 140                 
Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln
145                 150                 155                 160 
Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro
                165                 170                 175     
Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro
            180                 185                 190         
Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr
        195                 200                 205             
Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser
    210                 215                 220                 
Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr
225                 230                 235                 240 
Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln
                245                 250                 255     
Gln Ser Ser Ser Tyr Gly Gln Gln Ser Ser Phe Arg Gln Asp His Pro
            260                 265                 270         
Ser Ser Met Gly Val Tyr Gly Gln Glu Ser Gly Gly Phe Ser Gly Pro
        275                 280                 285             
Gly Glu Asn Arg Ser Met Ser Gly Pro Asp Asn Arg Gly Arg Gly Arg
    290                 295                 300                 
Gly Gly Phe Asp Arg Gly Gly Met Ser Arg Gly Gly Arg Gly Gly Gly
305                 310                 315                 320 
Arg Gly Gly Met Gly Leu Gln Ser Glu Ser Leu Val Tyr Thr Ser Ile
                325                 330                 335     
Leu Lys Lys Tyr Pro Tyr Ser Val Leu Ser Arg Gln His Asn Glu Lys
            340                 345                 350         
Trp Asp
        


<210> 7834
<211> 656
<212> PRT
<213> Homo sapiens

<400> 7834
Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln
 1               5                  10                  15      
Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr
            20                  25                  30          
Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr
        35                  40                  45              
Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr
    50                  55                  60                  
Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro
65                  70                  75                  80  
Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly
                85                  90                  95      
Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr
            100                 105                 110         
Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly
        115                 120                 125             
Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys
    130                 135                 140                 
Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln
145                 150                 155                 160 
Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro
                165                 170                 175     
Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro
            180                 185                 190         
Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr
        195                 200                 205             
Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser
    210                 215                 220                 
Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr
225                 230                 235                 240 
Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln
                245                 250                 255     
Gln Ser Ser Ser Tyr Gly Gln Gln Ser Ser Phe Arg Gln Asp His Pro
            260                 265                 270         
Ser Ser Met Gly Val Tyr Gly Gln Glu Ser Gly Gly Phe Ser Gly Pro
        275                 280                 285             
Gly Glu Asn Arg Ser Met Ser Gly Pro Asp Asn Arg Gly Arg Gly Arg
    290                 295                 300                 
Gly Gly Phe Asp Arg Gly Gly Met Ser Arg Gly Gly Arg Gly Gly Gly
305                 310                 315                 320 
Arg Gly Gly Met Gly Ser Ala Gly Glu Arg Gly Gly Phe Asn Lys Pro
                325                 330                 335     
Gly Gly Pro Met Asp Glu Gly Pro Asp Leu Asp Leu Gly Pro Pro Val
            340                 345                 350         
Asp Pro Asp Glu Asp Ser Asp Asn Ser Ala Ile Tyr Val Gln Gly Leu
        355                 360                 365             
Asn Asp Ser Val Thr Leu Asp Asp Leu Ala Asp Phe Phe Lys Gln Cys
    370                 375                 380                 
Gly Val Val Lys Met Asn Lys Arg Thr Gly Gln Pro Met Ile His Ile
385                 390                 395                 400 
Tyr Leu Asp Lys Glu Thr Gly Lys Pro Lys Gly Asp Ala Thr Val Ser
                405                 410                 415     
Tyr Glu Asp Pro Pro Thr Ala Lys Ala Ala Val Glu Trp Phe Asp Gly
            420                 425                 430         
Lys Asp Phe Gln Gly Ser Lys Leu Lys Val Ser Leu Ala Arg Lys Lys
        435                 440                 445             
Pro Pro Met Asn Ser Met Arg Gly Gly Leu Pro Pro Arg Glu Gly Arg
    450                 455                 460                 
Gly Met Pro Pro Pro Leu Arg Gly Gly Pro Gly Gly Pro Gly Gly Pro
465                 470                 475                 480 
Gly Gly Pro Met Gly Arg Met Gly Gly Arg Gly Gly Asp Arg Gly Gly
                485                 490                 495     
Phe Pro Pro Arg Gly Pro Arg Gly Ser Arg Gly Asn Pro Ser Gly Gly
            500                 505                 510         
Gly Asn Val Gln His Arg Ala Gly Asp Trp Gln Cys Pro Asn Pro Gly
        515                 520                 525             
Cys Gly Asn Gln Asn Phe Ala Trp Arg Thr Glu Cys Asn Gln Cys Lys
    530                 535                 540                 
Ala Pro Lys Pro Glu Gly Phe Leu Pro Pro Pro Phe Pro Pro Pro Gly
545                 550                 555                 560 
Gly Asp Arg Gly Arg Gly Gly Pro Gly Gly Met Arg Gly Gly Arg Gly
                565                 570                 575     
Gly Leu Met Asp Arg Gly Gly Pro Gly Gly Met Phe Arg Gly Gly Arg
            580                 585                 590         
Gly Gly Asp Arg Gly Gly Phe Arg Gly Gly Arg Gly Met Asp Arg Gly
        595                 600                 605             
Gly Phe Gly Gly Gly Arg Arg Gly Gly Pro Gly Gly Pro Pro Gly Pro
    610                 615                 620                 
Leu Met Glu Gln Met Gly Gly Arg Arg Gly Gly Arg Gly Gly Pro Gly
625                 630                 635                 640 
Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg Pro Tyr
                645                 650                 655     


<210> 7835
<211> 433
<212> PRT
<213> Homo sapiens

<400> 7835
Met Ala Leu Asp Leu Arg Thr Ile Phe Gln Cys Glu Pro Ser Glu Asn
 1               5                  10                  15      
Asn Leu Gly Ser Glu Asn Ser Ala Phe Gln Gln Ser Gln Gly Pro Ala
            20                  25                  30          
Val Gln Arg Glu Glu Gly Ile Ser Glu Phe Ser Arg Met Val Leu Asn
        35                  40                  45              
Ser Phe Gln Asp Ser Asn Asn Ser Tyr Ala Arg Gln Glu Leu Gln Arg
    50                  55                  60                  
Leu Tyr Arg Ile Phe His Ser Trp Leu Gln Pro Glu Lys His Ser Lys
65                  70                  75                  80  
Asp Glu Ile Ile Ser Leu Leu Val Leu Glu Gln Phe Met Ile Gly Gly
                85                  90                  95      
His Cys Asn Asp Lys Ala Ser Val Lys Glu Lys Trp Lys Ser Ser Gly
            100                 105                 110         
Lys Asn Leu Glu Arg Phe Ile Glu Asp Leu Thr Asp Asp Ser Ile Asn
        115                 120                 125             
Pro Pro Ala Leu Val His Val His Met Gln Gly Gln Glu Ala Leu Phe
    130                 135                 140                 
Ser Glu Asp Met Pro Leu Arg Asp Val Ile Val His Leu Thr Lys Gln
145                 150                 155                 160 
Val Asn Ala Gln Thr Thr Arg Glu Ala Asn Met Gly Thr Pro Ser Gln
                165                 170                 175     
Thr Ser Gln Asp Thr Ser Leu Glu Thr Gly Gln Gly Tyr Glu Asp Glu
            180                 185                 190         
Gln Asp Gly Trp Asn Ser Ser Ser Lys Thr Thr Arg Val Asn Glu Asn
        195                 200                 205             
Ile Thr Asn Gln Gly Asn Gln Ile Val Ser Leu Ile Ile Ile Gln Glu
    210                 215                 220                 
Glu Asn Gly Pro Arg Pro Glu Glu Gly Gly Val Ser Ser Asp Asn Pro
225                 230                 235                 240 
Tyr Asn Ser Lys Arg Ala Glu Leu Val Thr Ala Arg Ser Gln Glu Gly
                245                 250                 255     
Ser Ile Asn Gly Ile Thr Phe Gln Gly Val Pro Met Val Met Gly Ala
            260                 265                 270         
Gly Cys Ile Ser Gln Pro Glu Gln Ser Ser Pro Glu Ser Ala Leu Thr
        275                 280                 285             
His Gln Ser Asn Glu Gly Asn Ser Thr Cys Glu Val His Gln Lys Gly
    290                 295                 300                 
Ser His Gly Val Gln Lys Ser Tyr Lys Cys Glu Glu Cys Pro Lys Val
305                 310                 315                 320 
Phe Lys Tyr Leu Cys His Leu Leu Ala His Gln Arg Arg His Arg Asn
                325                 330                 335     
Glu Arg Pro Phe Val Cys Pro Glu Cys Gln Lys Gly Phe Phe Gln Ile
            340                 345                 350         
Ser Asp Leu Arg Val His Gln Ile Ile His Thr Gly Lys Lys Pro Phe
        355                 360                 365             
Thr Cys Ser Met Cys Lys Lys Ser Phe Ser His Lys Thr Asn Leu Arg
    370                 375                 380                 
Ser His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Pro Phe
385                 390                 395                 400 
Cys Lys Thr Ser Tyr Arg Gln Ser Ser Thr Tyr His Arg His Met Arg
                405                 410                 415     
Thr His Glu Lys Ile Thr Leu Pro Ser Val Pro Ser Thr Pro Glu Ala
            420                 425                 430         
Ser
    


<210> 7836
<211> 268
<212> PRT
<213> Homo sapiens

<400> 7836
Met Phe Arg Met Leu Asn Ser Ser Phe Glu Asp Asp Pro Phe Phe Ser
 1               5                  10                  15      
Glu Ser Ile Leu Ala His Arg Glu Asn Met Arg Gln Met Ile Arg Ser
            20                  25                  30          
Phe Ser Glu Pro Phe Gly Arg Asp Leu Leu Ser Ile Ser Asp Gly Arg
        35                  40                  45              
Gly Arg Ala His Asn Arg Arg Gly His Asn Asp Gly Glu Asp Ser Leu
    50                  55                  60                  
Thr His Thr Asp Val Ser Ser Phe Gln Thr Met Asp Gln Met Val Ser
65                  70                  75                  80  
Asn Met Arg Asn Tyr Met Gln Lys Leu Glu Arg Asn Phe Gly Gln Leu
                85                  90                  95      
Ser Val Asp Pro Asn Gly His Ser Phe Cys Ser Ser Ser Val Met Thr
            100                 105                 110         
Tyr Ser Lys Ile Gly Asp Glu Pro Pro Lys Val Phe Gln Ala Ser Thr
        115                 120                 125             
Gln Thr Arg Arg Ala Pro Gly Gly Ile Lys Glu Thr Arg Lys Ala Met
    130                 135                 140                 
Arg Asp Ser Asp Ser Gly Leu Glu Lys Met Ala Ile Gly His His Ile
145                 150                 155                 160 
His Asp Arg Ala His Val Ile Lys Lys Ser Lys Asn Lys Lys Thr Gly
                165                 170                 175     
Asp Glu Glu Val Asn Gln Glu Phe Ile Asn Met Asn Glu Ser Asp Ala
            180                 185                 190         
His Ala Phe Asp Glu Glu Trp Gln Ser Glu Val Leu Lys Tyr Lys Pro
        195                 200                 205             
Gly Arg His Asn Leu Gly Asn Thr Arg Met Arg Ser Val Gly His Glu
    210                 215                 220                 
Asn Pro Gly Ser Arg Glu Leu Lys Arg Arg Glu Lys Pro Gln Gln Ser
225                 230                 235                 240 
Pro Ala Ile Glu His Gly Arg Arg Ser Asn Val Leu Gly Asp Lys Leu
                245                 250                 255     
His Ile Lys Gly Ser Ser Val Lys Ser Asn Lys Lys
            260                 265             


<210> 7837
<211> 1235
<212> PRT
<213> Homo sapiens

<400> 7837
Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr
 1               5                  10                  15      
Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met
            20                  25                  30          
Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro
        35                  40                  45              
Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys
    50                  55                  60                  
Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg
65                  70                  75                  80  
Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile
                85                  90                  95      
Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile
            100                 105                 110         
Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu
        115                 120                 125             
Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp
    130                 135                 140                 
Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg
145                 150                 155                 160 
Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro
                165                 170                 175     
Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala
            180                 185                 190         
Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met
        195                 200                 205             
Glu Glu Ala Thr Ser Gly Val Asn Glu Ser Glu Met Ala Val Ala Ser
    210                 215                 220                 
Gly His Leu Asn Ser Thr Gly Val Leu Leu Glu Val Gly Gly Val Leu
225                 230                 235                 240 
Pro Met Ile His Gly Gly Glu Ile Gln Gln Thr Pro Asn Thr Val Ala
                245                 250                 255     
Ala Ser Pro Ala Ala Ser Gly Ala Pro Thr Leu Ser Arg Leu Leu Glu
            260                 265                 270         
Ala Gly Pro Thr Gln Phe Thr Thr Pro Leu Ala Ser Phe Thr Thr Val
        275                 280                 285             
Ala Ser Glu Pro Pro Val Lys Leu Val Pro Pro Pro Val Glu Ser Val
    290                 295                 300                 
Ser Gln Ala Thr Ile Val Met Met Pro Ala Leu Pro Ala Pro Ser Ser
305                 310                 315                 320 
Ala Pro Ala Val Ser Thr Thr Glu Ser Val Ala Pro Val Ser Gln Pro
                325                 330                 335     
Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His Thr Val Thr
            340                 345                 350         
Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn Ser Ile Lys
        355                 360                 365             
Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val Gly Ser Lys
    370                 375                 380                 
Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala Glu Lys Met
385                 390                 395                 400 
Asp Ile Ala Val Ser Tyr Thr Gly Glu Glu Leu Asp Phe Glu Thr Val
                405                 410                 415     
Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp His Pro Glu
            420                 425                 430         
Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe Cys Glu Glu
        435                 440                 445             
Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His Pro Ile Gln
    450                 455                 460                 
Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu Met Thr Val
465                 470                 475                 480 
Lys Gln Glu Arg Leu Asp Phe Glu Glu Thr Glu Asn Lys Gly Ile His
                485                 490                 495     
Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys Val Glu Pro
            500                 505                 510         
Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val Ala Gly Val
        515                 520                 525             
Val Pro Ala Thr Ser Met Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu
    530                 535                 540                 
Asp Glu Glu Leu Gly Ser Thr Ala Ala Gly Glu Ile Val Glu Ala Asp
545                 550                 555                 560 
Val Ala Ile Gly Lys Gly Asp Glu Thr Pro Leu Thr Asn Val Lys Thr
                565                 570                 575     
Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro
            580                 585                 590         
Ile Glu Asp Pro Leu Glu Ala Glu Thr Gln His Lys Phe Glu Met Ser
        595                 600                 605             
Asp Ser Leu Lys Glu Glu Ser Gly Thr Ile Phe Gly Ser Gln Ile Lys
    610                 615                 620                 
Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala
625                 630                 635                 640 
Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser
                645                 650                 655     
Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser
            660                 665                 670         
Ile His Asn Ala Thr Leu Gln Ser His Thr Leu Ala Asp Ser Ile Pro
        675                 680                 685             
Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu
    690                 695                 700                 
Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp
705                 710                 715                 720 
Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val
                725                 730                 735     
Thr Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met
            740                 745                 750         
Asp Leu Ser Thr Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser
        755                 760                 765             
Thr Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val
    770                 775                 780                 
Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala Val Glu Met
785                 790                 795                 800 
Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala Thr Gln Leu
                805                 810                 815     
Ile Met Gln Thr Ser Glu Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly
            820                 825                 830         
Arg Asp Ser Thr Arg Lys Gln Asp Ala Ser Glu Lys Asp Ser Val Pro
        835                 840                 845             
Met Gly Ser Pro Ala Phe Leu Leu Ser Leu Phe Met Gly His Glu Trp
    850                 855                 860                 
Val Trp Leu Asp Ser Glu Gln Asp His Pro Asn Asp Ser Glu Leu Ser
865                 870                 875                 880 
Asn Asp Cys Arg Ser Leu Phe Ser Ser Trp Asp Ser Ser Leu Asp Leu
                885                 890                 895     
Asp Val Gly Asn Trp Arg Glu Thr Glu Asp Pro Glu Ala Glu Glu Leu
            900                 905                 910         
Glu Glu Ser Ser Pro Glu Arg Glu Pro Ser Glu Leu Leu Val Gly Asp
        915                 920                 925             
Gly Gly Ser Glu Glu Ser Gln Glu Ala Ala Arg Lys Ala Ser His Gln
    930                 935                 940                 
Asn Leu Leu His Phe Leu Ser Glu Val Ala Tyr Leu Met Glu Pro Leu
945                 950                 955                 960 
Cys Ile Ser Ser Asn Glu Ser Ser Glu Gly Cys Cys Pro Pro Ser Gly
                965                 970                 975     
Thr Arg Gln Glu Gly Arg Glu Ile Lys Ala Ser Glu Gly Glu Arg Glu
            980                 985                 990         
Leu Cys Arg Glu Thr Glu Glu Leu Ser Ala Lys Gly Asp Pro Leu Val
        995                 1000                1005            
Ala Glu Lys Pro Leu Gly Glu Asn Gly Lys Pro Glu Val Ala Ser Ala
    1010                1015                1020                
Pro Ser Val Ile Cys Thr Val Gln Gly Leu Leu Thr Glu Ser Glu Glu
1025                1030                1035                1040
Gly Glu Ala Gln Gln Glu Ser Lys Gly Glu Asp Gln Gly Glu Val Tyr
                1045                1050                1055    
Val Ser Glu Met Glu Asp Gln Pro Pro Ser Gly Glu Cys Asp Asp Ala
            1060                1065                1070        
Phe Asn Ile Lys Glu Thr Pro Leu Val Asp Thr Leu Phe Ser His Ala
        1075                1080                1085            
Thr Ser Ser Lys Leu Thr Asp Leu Ser Gln Asp Asp Pro Val Gln Asp
    1090                1095                1100                
His Leu Leu Phe Lys Lys Thr Leu Leu Pro Val Trp Lys Met Ile Ala
1105                1110                1115                1120
Ser His Arg Phe Ser Ser Pro Phe Leu Lys Pro Val Ser Glu Arg Gln
                1125                1130                1135    
Ala Pro Gly Tyr Lys Asp Val Val Lys Arg Pro Met Asp Leu Thr Ser
            1140                1145                1150        
Leu Lys Arg Asn Leu Ser Lys Gly Arg Ile Arg Thr Met Ala Gln Phe
        1155                1160                1165            
Leu Arg Asp Leu Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Asp
    1170                1175                1180                
Ser Asp His His Val Tyr His Met Ala Val Glu Met Arg Arg Glu Val
1185                1190                1195                1200
Leu Glu Gln Ile Gln Val Leu Asn Ile Trp Leu Asp Lys Arg Lys Gly
                1205                1210                1215    
Ser Ser Ser Leu Glu Gly Glu Pro Ala Asn Pro Val Asp Asp Gly Lys
            1220                1225                1230        
Pro Val Phe
        1235


<210> 7838
<211> 951
<212> PRT
<213> Homo sapiens

<400> 7838
Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr
 1               5                  10                  15      
Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met
            20                  25                  30          
Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro
        35                  40                  45              
Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys
    50                  55                  60                  
Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg
65                  70                  75                  80  
Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile
                85                  90                  95      
Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile
            100                 105                 110         
Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu
        115                 120                 125             
Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp
    130                 135                 140                 
Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg
145                 150                 155                 160 
Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro
                165                 170                 175     
Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala
            180                 185                 190         
Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met
        195                 200                 205             
Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu Pro Ser Thr Pro
    210                 215                 220                 
Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro Pro Gly Ser Ala
225                 230                 235                 240 
Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp Ser Pro Gln Lys
                245                 250                 255     
Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser Pro Leu Leu Ser
            260                 265                 270         
Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser Pro Arg Leu Val
        275                 280                 285             
Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Thr Gly
    290                 295                 300                 
Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu
305                 310                 315                 320 
Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro Ala Ala Ser Gly
                325                 330                 335     
Ala Pro Thr Leu Ser Arg Leu Leu Glu Ala Gly Pro Thr Gln Phe Thr
            340                 345                 350         
Thr Pro Leu Ala Ser Phe Thr Thr Val Ala Ser Glu Pro Pro Val Lys
        355                 360                 365             
Leu Val Pro Pro Pro Val Glu Ser Val Ser Gln Ala Thr Ile Val Met
    370                 375                 380                 
Met Pro Ala Leu Pro Ala Pro Ser Ser Ala Pro Ala Val Ser Thr Thr
385                 390                 395                 400 
Glu Ser Val Ala Pro Val Ser Gln Pro Asp Asn Cys Val Pro Met Glu
                405                 410                 415     
Ala Val Gly Asp Pro His Thr Val Thr Val Ser Met Asp Ser Ser Glu
            420                 425                 430         
Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly
        435                 440                 445             
Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys
    450                 455                 460                 
Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Thr
465                 470                 475                 480 
Gly Glu Glu Leu Asp Phe Glu Thr Val Gly Asp Ile Ile Ala Ile Ile
                485                 490                 495     
Glu Asp Lys Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala Val
            500                 505                 510         
Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu
        515                 520                 525             
Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val
    530                 535                 540                 
Pro Leu Pro Ala Pro Glu Met Thr Val Lys Gln Glu Arg Leu Asp Phe
545                 550                 555                 560 
Glu Glu Thr Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu
                565                 570                 575     
Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile
            580                 585                 590         
Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro Ala Thr Ser Met Glu
        595                 600                 605             
Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr
    610                 615                 620                 
Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala Ile Gly Lys Gly Asp
625                 630                 635                 640 
Glu Thr Pro Leu Thr Asn Val Lys Thr Glu Ala Ser Pro Glu Ser Met
                645                 650                 655     
Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala
            660                 665                 670         
Glu Thr Gln His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser
        675                 680                 685             
Gly Thr Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu
    690                 695                 700                 
Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu
705                 710                 715                 720 
Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro
                725                 730                 735     
Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn Ala Thr Leu Gln
            740                 745                 750         
Ser His Thr Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln
        755                 760                 765             
Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile
    770                 775                 780                 
Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His Arg
785                 790                 795                 800 
Tyr Ala Asn Val Phe Leu Gln Pro Val Thr Asp Asp Ile Ala Pro Gly
                805                 810                 815     
Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser Thr Ile Lys Lys
            820                 825                 830         
Asn Ile Glu Asn Gly Leu Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp
        835                 840                 845             
Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His
    850                 855                 860                 
Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu Gln
865                 870                 875                 880 
Ile Gln Gln Phe Leu Ala Thr Gln Leu Ile Met Gln Thr Ser Glu Ser
                885                 890                 895     
Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln
            900                 905                 910         
Asp Ala Ser Glu Lys Asp Ser Val Pro Met Gly Ser Pro Ala Phe Leu
        915                 920                 925             
Leu Ser Leu Phe Asp Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu
    930                 935                 940                 
Ala Asp Met Lys Met Lys Lys
945                 950     


<210> 7839
<211> 757
<212> PRT
<213> Homo sapiens

<400> 7839
Met Ser Phe Ala Met Thr Leu Lys Lys Lys Leu Glu Glu Glu Glu Ala
 1               5                  10                  15      
Glu Val Lys Arg Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala
            20                  25                  30          
Val Lys Thr Pro Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro
        35                  40                  45              
Ile Asp Ser Ala Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr
    50                  55                  60                  
Pro Thr Thr Met Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu
65                  70                  75                  80  
Pro Ser Thr Pro Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro
                85                  90                  95      
Pro Gly Ser Ala Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp
            100                 105                 110         
Ser Pro Gln Lys Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser
        115                 120                 125             
Pro Leu Leu Ser Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser
    130                 135                 140                 
Pro Arg Leu Val Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu
145                 150                 155                 160 
Asn Ser Thr Gly Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile
                165                 170                 175     
His Gly Gly Glu Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro
            180                 185                 190         
Ala Ala Ser Glu Ser Val Ser Gln Ala Thr Ile Val Met Met Pro Ala
        195                 200                 205             
Leu Pro Ala Pro Ser Ser Ala Pro Ala Val Ser Thr Thr Glu Ser Val
    210                 215                 220                 
Ala Pro Val Ser Gln Pro Asp Asn Cys Val Pro Met Glu Ala Val Gly
225                 230                 235                 240 
Asp Pro His Thr Val Thr Val Ser Met Asp Ser Ser Glu Ile Ser Met
                245                 250                 255     
Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly Val Ala Glu
            260                 265                 270         
Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu
        275                 280                 285             
Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Thr Gly Glu Glu
    290                 295                 300                 
Leu Asp Phe Glu Thr Val Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys
305                 310                 315                 320 
Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala Val Glu Ala Ala
                325                 330                 335     
Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro
            340                 345                 350         
Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val Pro Leu Pro
        355                 360                 365             
Ala Pro Glu Met Thr Val Lys Gln Glu Arg Leu Asp Phe Glu Glu Thr
    370                 375                 380                 
Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu Pro Ser Ala
385                 390                 395                 400 
Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile Ser Gly Ala
                405                 410                 415     
Glu Ile Val Ala Gly Val Val Pro Ala Thr Ser Met Glu Pro Pro Glu
            420                 425                 430         
Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr Ala Ala Gly
        435                 440                 445             
Glu Ile Leu Glu Ala Asp Val Ala Ile Gly Lys Gly Asp Glu Thr Pro
    450                 455                 460                 
Leu Thr Asn Val Lys Thr Glu Ala Ser Pro Glu Ser Met Leu Ser Pro
465                 470                 475                 480 
Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala Glu Thr Gln
                485                 490                 495     
His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser Gly Thr Ile
            500                 505                 510         
Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp
        515                 520                 525             
Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln
    530                 535                 540                 
Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro Val Ser Glu
545                 550                 555                 560 
Ser Asp Asp Gly Phe Ser Ile His Asn Ala Thr Leu Gln Ser His Thr
                565                 570                 575     
Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln Phe Ser Val
            580                 585                 590         
Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys
        595                 600                 605             
Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His Arg Tyr Ala Asn
    610                 615                 620                 
Val Phe Leu Gln Pro Val Thr Asp Asp Ile Ala Pro Gly Tyr His Ser
625                 630                 635                 640 
Ile Val Gln Arg Pro Met Asp Leu Ser Thr Ile Lys Lys Asn Ile Glu
                645                 650                 655     
Asn Gly Leu Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp Ile Met Leu
            660                 665                 670         
Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His Asp Val Tyr
        675                 680                 685             
His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu Gln Ile Gln Gln
    690                 695                 700                 
Phe Leu Ala Thr Gln Leu Ile Met Gln Thr Ser Glu Ser Gly Ile Ser
705                 710                 715                 720 
Ala Lys Ser Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln Asp Ala Ser
                725                 730                 735     
Glu Lys Asp Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu Ala Asp
            740                 745                 750         
Met Lys Met Lys Lys
        755         


<210> 7840
<211> 1849
<212> PRT
<213> Homo sapiens

<400> 7840
Met Ser Val Gly Glu Leu Tyr Ser Gln Cys Thr Arg Val Trp Ile Pro
 1               5                  10                  15      
Asp Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys
            20                  25                  30          
Glu Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu
        35                  40                  45              
Glu Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn
    50                  55                  60                  
Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu
65                  70                  75                  80  
His Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser
                85                  90                  95      
Asn His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro
            100                 105                 110         
Tyr Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Ala Tyr Ser
        115                 120                 125             
Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu
    130                 135                 140                 
Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile
145                 150                 155                 160 
Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala
                165                 170                 175     
Met Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile
            180                 185                 190         
Glu Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn
        195                 200                 205             
Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile
    210                 215                 220                 
Gln Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg
225                 230                 235                 240 
Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu
                245                 250                 255     
Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro
            260                 265                 270         
Glu Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr
        275                 280                 285             
Ser Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp
    290                 295                 300                 
Phe Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser
305                 310                 315                 320 
His Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly
                325                 330                 335     
Ser Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser
            340                 345                 350         
Pro Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu
        355                 360                 365             
His Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr
    370                 375                 380                 
Ser Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala
385                 390                 395                 400 
Arg Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile
                405                 410                 415     
Val Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser
            420                 425                 430         
Phe Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn
        435                 440                 445             
Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln
    450                 455                 460                 
Gln Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys
465                 470                 475                 480 
Glu Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys
                485                 490                 495     
Ile Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu
            500                 505                 510         
Glu Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu
        515                 520                 525             
Tyr Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser
    530                 535                 540                 
Asn Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu
545                 550                 555                 560 
Ser Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln
                565                 570                 575     
Ile Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe
            580                 585                 590         
His Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser
        595                 600                 605             
Ser Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser
    610                 615                 620                 
Asn Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg Thr Ser Leu
625                 630                 635                 640 
His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His Tyr Val Arg
                645                 650                 655     
Cys Ile Lys Pro Asn Asp Glu Lys Leu Pro Phe His Phe Asp Pro Lys
            660                 665                 670         
Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu Thr Ile Arg
        675                 680                 685             
Ile Ser Ala Ala Gly Tyr Pro Ser Arg Trp Ala Tyr His Asp Phe Phe
    690                 695                 700                 
Asn Arg Tyr Arg Val Leu Val Lys Lys Arg Glu Leu Ala Asn Thr Asp
705                 710                 715                 720 
Lys Lys Ala Ile Cys Arg Ser Val Leu Glu Asn Leu Ile Lys Asp Pro
                725                 730                 735     
Asp Lys Phe Gln Phe Gly Arg Thr Lys Ile Phe Phe Arg Ala Gly Gln
            740                 745                 750         
Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Phe Arg Thr Ala Thr
        755                 760                 765             
Ile Met Ile Gln Lys Thr Val Arg Gly Trp Leu Gln Lys Val Lys Tyr
    770                 775                 780                 
His Arg Leu Lys Gly Ala Thr Leu Thr Leu Gln Arg Tyr Cys Arg Gly
785                 790                 795                 800 
His Leu Ala Arg Arg Leu Ala Glu His Leu Arg Arg Ile Arg Ala Ala
                805                 810                 815     
Val Val Leu Gln Lys His Tyr Arg Met Gln Arg Ala Arg Gln Ala Tyr
            820                 825                 830         
Gln Arg Val Arg Arg Ala Ala Val Val Ile Gln Ala Phe Thr Arg Ala
        835                 840                 845             
Met Phe Val Arg Arg Thr Tyr Arg Gln Val Leu Met Glu His Lys Ala
    850                 855                 860                 
Thr Thr Ile Gln Lys His Val Arg Gly Trp Met Ala Arg Arg His Phe
865                 870                 875                 880 
Gln Arg Leu Arg Asp Ala Ala Ile Val Ile Gln Cys Ala Phe Arg Met
                885                 890                 895     
Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg Ile Glu Ala Arg Ser
            900                 905                 910         
Ala Glu His Leu Lys Arg Leu Asn Val Gly Met Glu Asn Lys Val Val
        915                 920                 925             
Gln Leu Gln Arg Lys Ile Asp Glu Gln Asn Lys Glu Phe Lys Thr Leu
    930                 935                 940                 
Ser Glu Gln Leu Ser Val Thr Thr Ser Thr Tyr Thr Met Glu Val Glu
945                 950                 955                 960 
Arg Leu Lys Lys Glu Leu Val His Tyr Gln Gln Ser Pro Gly Glu Asp
                965                 970                 975     
Thr Ser Leu Arg Leu Gln Glu Glu Val Glu Ser Leu Arg Thr Glu Leu
            980                 985                 990         
Gln Arg Ala His Ser Glu Arg Lys Ile Leu Glu Asp Ala His Ser Arg
        995                 1000                1005            
Glu Lys Asp Glu Leu Arg Lys Arg Val Ala Asp Leu Glu Gln Glu Asn
    1010                1015                1020                
Ala Leu Leu Lys Asp Glu Lys Glu Gln Leu Asn Asn Gln Ile Leu Cys
1025                1030                1035                1040
Gln Ser Lys Asp Glu Phe Ala Gln Asn Ser Val Lys Glu Asn Leu Leu
                1045                1050                1055    
Met Lys Lys Glu Leu Glu Glu Glu Arg Ser Arg Tyr Gln Asn Leu Val
            1060                1065                1070        
Lys Glu Tyr Ser Gln Leu Glu Gln Arg Tyr Asp Asn Leu Arg Asp Glu
        1075                1080                1085            
Met Thr Ile Ile Lys Gln Thr Pro Gly His Arg Arg Asn Pro Ser Asn
    1090                1095                1100                
Gln Ser Ser Leu Glu Ser Asp Ser Asn Tyr Pro Ser Ile Ser Thr Ser
1105                1110                1115                1120
Glu Ile Gly Asp Thr Glu Asp Ala Leu Gln Gln Val Glu Glu Ile Gly
                1125                1130                1135    
Leu Glu Lys Ala Ala Met Asp Met Thr Val Phe Leu Lys Leu Gln Lys
            1140                1145                1150        
Arg Val Arg Glu Leu Glu Gln Glu Arg Lys Lys Leu Gln Val Gln Leu
        1155                1160                1165            
Glu Lys Arg Glu Gln Gln Asp Ser Lys Lys Val Gln Ala Glu Pro Pro
    1170                1175                1180                
Gln Thr Asp Ile Asp Leu Asp Pro Asn Ala Asp Leu Ala Tyr Asn Ser
1185                1190                1195                1200
Leu Lys Arg Gln Glu Leu Glu Ser Glu Asn Lys Lys Leu Lys Asn Asp
                1205                1210                1215    
Leu Asn Glu Leu Arg Lys Ala Val Ala Asp Gln Ala Thr Gln Asn Asn
            1220                1225                1230        
Ser Ser His Gly Ser Pro Asp Ser Tyr Ser Leu Leu Leu Asn Gln Leu
        1235                1240                1245            
Lys Leu Ala His Glu Glu Leu Glu Val Arg Lys Glu Glu Val Leu Ile
    1250                1255                1260                
Leu Arg Thr Gln Ile Val Ser Ala Asp Gln Arg Arg Leu Ala Gly Arg
1265                1270                1275                1280
Asn Ala Glu Pro Asn Ile Asn Ala Arg Ser Ser Trp Pro Asn Ser Glu
                1285                1290                1295    
Lys His Val Asp Gln Glu Asp Ala Ile Glu Ala Tyr His Gly Val Cys
            1300                1305                1310        
Gln Thr Asn Ser Lys Thr Glu Asp Trp Gly Tyr Leu Asn Glu Asp Gly
        1315                1320                1325            
Glu Leu Gly Leu Ala Tyr Gln Gly Leu Lys Gln Val Ala Arg Leu Leu
    1330                1335                1340                
Glu Ala Gln Leu Gln Ala Gln Ser Leu Glu His Glu Glu Glu Val Glu
1345                1350                1355                1360
His Leu Lys Ala Gln Leu Glu Ala Leu Lys Glu Glu Met Asp Lys Gln
                1365                1370                1375    
Gln Gln Thr Phe Cys Gln Thr Leu Leu Leu Ser Pro Glu Ala Gln Val
            1380                1385                1390        
Glu Phe Gly Val Gln Gln Glu Ile Ser Arg Leu Thr Asn Glu Asn Leu
        1395                1400                1405            
Asp Leu Lys Glu Leu Val Glu Lys Leu Glu Lys Asn Glu Arg Lys Leu
    1410                1415                1420                
Lys Lys Gln Leu Lys Ile Tyr Met Lys Lys Ala Gln Asp Leu Glu Ala
1425                1430                1435                1440
Ala Gln Ala Leu Ala Gln Ser Glu Arg Lys Arg His Glu Leu Asn Arg
                1445                1450                1455    
Gln Val Thr Val Gln Arg Lys Glu Lys Asp Phe Gln Gly Met Leu Glu
            1460                1465                1470        
Tyr His Lys Glu Asp Glu Ala Leu Leu Ile Arg Asn Leu Val Thr Asp
        1475                1480                1485            
Leu Lys Pro Gln Met Leu Ser Gly Thr Val Pro Cys Leu Pro Ala Tyr
    1490                1495                1500                
Ile Leu Tyr Met Cys Ile Arg His Ala Asp Tyr Thr Asn Asp Asp Leu
1505                1510                1515                1520
Lys Val His Ser Leu Leu Thr Ser Thr Ile Asn Gly Ile Lys Lys Val
                1525                1530                1535    
Leu Lys Lys His Asn Asp Asp Phe Glu Met Thr Ser Phe Trp Leu Ser
            1540                1545                1550        
Asn Thr Cys Arg Leu Leu His Cys Leu Lys Gln Tyr Ser Gly Asp Glu
        1555                1560                1565            
Gly Phe Met Thr Gln Asn Thr Ala Lys Gln Asn Glu His Cys Leu Lys
    1570                1575                1580                
Asn Phe Asp Leu Thr Glu Tyr Arg Gln Val Leu Ser Asp Leu Ser Ile
1585                1590                1595                1600
Gln Ile Tyr Gln Gln Leu Ile Lys Ile Ala Glu Gly Val Leu Gln Pro
                1605                1610                1615    
Met Ile Val Ser Ala Met Leu Glu Asn Glu Ser Ile Gln Gly Leu Ser
            1620                1625                1630        
Gly Val Lys Pro Thr Gly Tyr Arg Lys Arg Ser Ser Ser Met Ala Asp
        1635                1640                1645            
Gly Asp Asn Ser Tyr Cys Leu Glu Ala Ile Ile Arg Gln Met Asn Ala
    1650                1655                1660                
Phe His Thr Val Met Cys Asp Gln Gly Leu Asp Pro Glu Ile Ile Leu
1665                1670                1675                1680
Gln Val Phe Lys Gln Leu Phe Tyr Met Ile Asn Ala Val Thr Leu Asn
                1685                1690                1695    
Asn Leu Leu Leu Arg Lys Asp Val Cys Ser Trp Ser Thr Gly Met Gln
            1700                1705                1710        
Leu Arg Tyr Asn Ile Ser Gln Leu Glu Glu Trp Leu Arg Gly Arg Asn
        1715                1720                1725            
Leu His Gln Ser Gly Ala Val Gln Thr Met Glu Pro Leu Ile Gln Ala
    1730                1735                1740                
Ala Gln Leu Leu Gln Leu Lys Lys Lys Thr Gln Glu Asp Ala Glu Ala
1745                1750                1755                1760
Ile Cys Ser Leu Cys Thr Ser Leu Ser Thr Gln Gln Ile Val Lys Ile
                1765                1770                1775    
Leu Asn Leu Tyr Thr Pro Leu Asn Glu Phe Glu Glu Arg Val Thr Val
            1780                1785                1790        
Ala Phe Ile Arg Thr Ile Gln Ala Gln Leu Gln Glu Arg Asn Asp Pro
        1795                1800                1805            
Gln Gln Leu Leu Leu Asp Ala Lys His Met Phe Pro Val Leu Phe Pro
    1810                1815                1820                
Phe Asn Pro Ser Ser Leu Thr Met Asp Ser Ile His Ile Pro Ala Cys
1825                1830                1835                1840
Leu Asn Leu Glu Phe Leu Asn Glu Val
                1845                


<210> 7841
<211> 963
<212> PRT
<213> Homo sapiens

<400> 7841
Met Glu His Lys Ala Thr Thr Ile Gln Lys His Val Arg Gly Trp Met
 1               5                  10                  15      
Ala Arg Arg His Phe Gln Arg Leu Arg Asp Ala Ala Ile Val Ile Gln
            20                  25                  30          
Cys Ala Phe Arg Met Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg
        35                  40                  45              
Ile Glu Ala Arg Ser Ala Glu His Leu Lys Arg Leu Asn Val Gly Met
    50                  55                  60                  
Glu Asn Lys Val Val Gln Leu Gln Arg Lys Ile Asp Glu Gln Asn Lys
65                  70                  75                  80  
Glu Phe Lys Thr Leu Ser Glu Gln Leu Ser Val Thr Thr Ser Thr Tyr
                85                  90                  95      
Thr Met Glu Val Glu Arg Leu Lys Lys Glu Leu Val His Tyr Gln Gln
            100                 105                 110         
Ser Pro Gly Glu Asp Thr Ser Leu Arg Leu Gln Glu Glu Val Glu Ser
        115                 120                 125             
Leu Arg Thr Glu Leu Gln Arg Ala His Ser Glu Arg Lys Ile Leu Glu
    130                 135                 140                 
Asp Ala His Ser Arg Glu Lys Asp Glu Leu Arg Lys Arg Val Ala Asp
145                 150                 155                 160 
Leu Glu Gln Glu Asn Ala Leu Leu Lys Asp Glu Lys Glu Gln Leu Asn
                165                 170                 175     
Asn Gln Ile Leu Cys Gln Ser Lys Asp Glu Phe Ala Gln Asn Ser Val
            180                 185                 190         
Lys Glu Asn Leu Met Lys Lys Glu Leu Glu Glu Glu Arg Ser Arg Tyr
        195                 200                 205             
Gln Asn Leu Val Lys Glu Tyr Ser Gln Leu Glu Gln Arg Tyr Asp Asn
    210                 215                 220                 
Leu Arg Asp Glu Met Thr Ile Ile Lys Gln Thr Pro Gly His Arg Arg
225                 230                 235                 240 
Asn Pro Ser Asn Gln Ser Ser Leu Glu Ser Asp Ser Asn Tyr Pro Ser
                245                 250                 255     
Ile Ser Thr Ser Glu Ile Gly Asp Thr Glu Asp Ala Leu Gln Gln Val
            260                 265                 270         
Glu Glu Ile Gly Leu Glu Lys Ala Ala Met Asp Met Thr Val Phe Leu
        275                 280                 285             
Lys Leu Gln Lys Arg Val Arg Glu Leu Glu Gln Glu Arg Lys Lys Leu
    290                 295                 300                 
Gln Val Gln Leu Glu Lys Arg Glu Gln Gln Asp Ser Lys Lys Val Gln
305                 310                 315                 320 
Ala Glu Pro Pro Gln Thr Asp Ile Asp Leu Asp Pro Asn Ala Asp Leu
                325                 330                 335     
Ala Tyr Asn Ser Leu Lys Arg Gln Glu Leu Glu Ser Glu Asn Lys Lys
            340                 345                 350         
Leu Lys Asn Asp Leu Asn Glu Leu Arg Lys Ala Val Ala Asp Gln Ala
        355                 360                 365             
Thr Gln Asn Asn Ser Ser His Gly Ser Pro Asp Ser Tyr Ser Leu Leu
    370                 375                 380                 
Leu Asn Gln Leu Lys Leu Ala His Glu Glu Leu Glu Val Arg Lys Glu
385                 390                 395                 400 
Glu Val Leu Ile Leu Arg Thr Gln Ile Val Ser Ala Asp Gln Arg Arg
                405                 410                 415     
Leu Ala Gly Arg Asn Ala Glu Pro Asn Ile Asn Ala Arg Ser Ser Trp
            420                 425                 430         
Pro Asn Ser Glu Lys His Val Asp Gln Glu Asp Ala Ile Glu Ala Tyr
        435                 440                 445             
His Gly Val Cys Gln Thr Asn Arg Leu Leu Glu Ala Gln Leu Gln Ala
    450                 455                 460                 
Gln Ser Leu Glu His Glu Glu Glu Val Glu His Leu Lys Ala Gln Leu
465                 470                 475                 480 
Glu Ala Leu Lys Glu Glu Met Asp Lys Gln Gln Gln Thr Phe Cys Gln
                485                 490                 495     
Thr Leu Leu Leu Ser Pro Glu Ala Gln Val Glu Phe Gly Val Gln Gln
            500                 505                 510         
Glu Ile Ser Arg Leu Thr Asn Glu Asn Leu Asp Leu Lys Glu Leu Val
        515                 520                 525             
Glu Lys Leu Glu Lys Asn Glu Arg Lys Leu Lys Lys Gln Leu Lys Ile
    530                 535                 540                 
Tyr Met Lys Lys Ala Gln Asp Leu Glu Ala Ala Gln Ala Leu Ala Gln
545                 550                 555                 560 
Ser Glu Arg Lys Arg His Glu Leu Asn Arg Gln Val Thr Val Gln Arg
                565                 570                 575     
Lys Glu Lys Asp Phe Gln Gly Met Leu Glu Tyr His Lys Glu Asp Glu
            580                 585                 590         
Ala Leu Leu Ile Arg Asn Leu Val Thr Asp Leu Lys Pro Gln Met Leu
        595                 600                 605             
Ser Gly Thr Val Pro Cys Leu Pro Ala Tyr Ile Leu Tyr Met Cys Ile
    610                 615                 620                 
Arg His Ala Asp Tyr Thr Asn Asp Asp Leu Lys Val His Ser Leu Leu
625                 630                 635                 640 
Thr Ser Thr Ile Asn Gly Ile Lys Lys Val Leu Lys Lys His Asn Asp
                645                 650                 655     
Asp Phe Glu Met Thr Ser Phe Trp Leu Ser Asn Thr Cys Arg Leu Leu
            660                 665                 670         
His Cys Leu Lys Gln Tyr Ser Gly Asp Glu Gly Phe Met Thr Gln Asn
        675                 680                 685             
Thr Ala Lys Gln Asn Glu His Cys Leu Lys Asn Phe Asp Leu Thr Glu
    690                 695                 700                 
Tyr Arg Gln Val Leu Ser Asp Leu Ser Ile Gln Ile Tyr Gln Gln Leu
705                 710                 715                 720 
Ile Lys Ile Ala Glu Gly Val Leu Gln Pro Met Ile Val Ser Ala Met
                725                 730                 735     
Leu Glu Asn Glu Ser Ile Gln Gly Leu Ser Gly Val Lys Pro Thr Gly
            740                 745                 750         
Tyr Arg Lys Arg Ser Ser Ser Met Ala Asp Gly Asp Asn Ser Tyr Cys
        755                 760                 765             
Leu Glu Ala Ile Ile Arg Gln Met Asn Ala Phe His Thr Val Met Cys
    770                 775                 780                 
Asp Gln Gly Leu Asp Pro Glu Ile Ile Leu Gln Val Phe Lys Gln Leu
785                 790                 795                 800 
Phe Tyr Met Ile Asn Ala Val Thr Leu Asn Asn Leu Leu Leu Arg Lys
                805                 810                 815     
Asp Val Cys Ser Trp Ser Thr Gly Met Gln Leu Arg Tyr Asn Ile Ser
            820                 825                 830         
Gln Leu Glu Glu Trp Leu Arg Gly Arg Asn Leu His Gln Ser Gly Ala
        835                 840                 845             
Val Gln Thr Met Glu Pro Leu Ile Gln Ala Ala Gln Leu Leu Gln Leu
    850                 855                 860                 
Lys Lys Lys Thr Gln Glu Asp Ala Glu Ala Ile Cys Ser Leu Cys Thr
865                 870                 875                 880 
Ser Leu Ser Thr Gln Gln Ile Val Lys Ile Leu Asn Leu Tyr Thr Pro
                885                 890                 895     
Leu Asn Glu Phe Glu Glu Arg Val Thr Val Ala Phe Ile Arg Thr Ile
            900                 905                 910         
Gln Ala Gln Leu Gln Glu Arg Asn Asp Pro Gln Gln Leu Leu Leu Asp
        915                 920                 925             
Ala Lys His Met Phe Pro Val Leu Phe Pro Phe Asn Pro Ser Ser Leu
    930                 935                 940                 
Thr Met Asp Ser Ile His Ile Pro Ala Cys Leu Asn Leu Glu Phe Leu
945                 950                 955                 960 
Asn Glu Val
            


<210> 7842
<211> 354
<212> PRT
<213> Homo sapiens

<400> 7842
Leu Tyr Asp Gln Ala Leu Leu Gly Ile Leu Gln His Val Gly Asn Val
 1               5                  10                  15      
Gln Asp Phe Leu Arg Val Leu Phe Gly Phe Leu Tyr Arg Lys Thr Asp
            20                  25                  30          
Phe Tyr Arg Leu Leu Arg His Pro Ser Asp Arg Met Gly Phe Pro Pro
        35                  40                  45              
Gly Ala Ala Gln Ala Leu Val Leu Gln Val Phe Lys Thr Phe Asp His
    50                  55                  60                  
Met Ala Arg Gln Asp Asp Glu Lys Arg Arg Gln Glu Leu Glu Glu Lys
65                  70                  75                  80  
Ile Arg Arg Lys Glu Glu Glu Glu Ala Lys Thr Val Ser Ala Ala Ala
                85                  90                  95      
Ala Glu Lys Glu Pro Val Pro Val Pro Val Gln Glu Ile Glu Ile Asp
            100                 105                 110         
Ser Thr Thr Glu Leu Asp Gly His Gln Glu Val Glu Lys Val Gln Pro
        115                 120                 125             
Pro Gly Pro Val Lys Glu Met Ala His Gly Ser Gln Glu Ala Glu Ala
    130                 135                 140                 
Pro Gly Ala Val Ala Gly Ala Ala Glu Val Pro Arg Glu Pro Pro Ile
145                 150                 155                 160 
Leu Pro Arg Ile Gln Glu Gln Phe Gln Lys Asn Pro Asp Ser Tyr Asn
                165                 170                 175     
Gly Ala Val Arg Glu Asn Tyr Thr Trp Ser Gln Asp Tyr Thr Asp Leu
            180                 185                 190         
Glu Val Arg Val Pro Val Pro Lys His Val Val Lys Gly Lys Gln Val
        195                 200                 205             
Ser Val Ala Leu Ser Ser Ser Ser Ile Arg Val Ala Met Leu Glu Glu
    210                 215                 220                 
Asn Gly Glu Arg Val Leu Met Glu Gly Lys Leu Thr His Lys Ile Asn
225                 230                 235                 240 
Thr Glu Ser Ser Leu Trp Ser Leu Glu Pro Gly Lys Cys Val Leu Val
                245                 250                 255     
Asn Leu Ser Lys Val Gly Glu Tyr Trp Trp Asn Ala Ile Leu Glu Gly
            260                 265                 270         
Glu Glu Pro Ile Asp Ile Asp Lys Ile Asn Lys Glu Arg Ser Met Ala
        275                 280                 285             
Thr Val Asp Glu Glu Glu Gln Ala Val Leu Asp Arg Leu Thr Phe Asp
    290                 295                 300                 
Tyr His Gln Lys Leu Gln Gly Lys Pro Gln Ser His Glu Leu Lys Val
305                 310                 315                 320 
His Glu Met Leu Lys Lys Gly Trp Asp Ala Glu Gly Ser Pro Phe Arg
                325                 330                 335     
Gly Gln Arg Phe Asp Pro Ala Met Phe Asn Ile Ser Pro Gly Ala Val
            340                 345                 350         
Gln Phe
        


<210> 7843
<211> 361
<212> PRT
<213> Homo sapiens

<400> 7843
Met Glu Pro Gly Ala Ala Glu Leu Tyr Asp Gln Ala Leu Leu Gly Ile
 1               5                  10                  15      
Leu Gln His Val Gly Asn Val Gln Asp Phe Leu Arg Val Leu Phe Gly
            20                  25                  30          
Phe Leu Tyr Arg Lys Thr Asp Phe Tyr Arg Leu Leu Arg His Pro Ser
        35                  40                  45              
Asp Arg Met Gly Phe Pro Pro Gly Ala Ala Gln Ala Leu Val Leu Gln
    50                  55                  60                  
Val Phe Lys Thr Phe Asp His Met Ala Arg Gln Asp Asp Glu Lys Arg
65                  70                  75                  80  
Arg Gln Glu Leu Glu Glu Lys Ile Arg Arg Lys Glu Glu Glu Glu Ala
                85                  90                  95      
Lys Thr Val Ser Ala Ala Ala Ala Glu Lys Glu Pro Val Pro Val Pro
            100                 105                 110         
Val Gln Glu Ile Glu Ile Asp Ser Thr Thr Glu Leu Asp Gly His Gln
        115                 120                 125             
Glu Val Glu Lys Val Gln Pro Pro Gly Pro Val Lys Glu Met Ala His
    130                 135                 140                 
Gly Ser Gln Glu Ala Glu Ala Pro Gly Ala Val Ala Gly Ala Ala Glu
145                 150                 155                 160 
Val Pro Arg Glu Pro Pro Ile Leu Pro Arg Ile Gln Glu Gln Phe Gln
                165                 170                 175     
Lys Asn Pro Asp Ser Tyr Asn Gly Ala Val Arg Glu Asn Tyr Thr Trp
            180                 185                 190         
Ser Gln Asp Tyr Thr Asp Leu Glu Val Arg Val Pro Leu Pro Lys His
        195                 200                 205             
Val Val Lys Gly Lys Gln Val Ser Val Ala Leu Ser Ser Ser Ser Ile
    210                 215                 220                 
Arg Val Ala Met Leu Glu Glu Asn Gly Glu Cys Val Leu Met Glu Gly
225                 230                 235                 240 
Lys Leu Thr His Lys Ile Asn Thr Glu Ser Ser Leu Trp Ser Leu Glu
                245                 250                 255     
Pro Gly Lys Cys Val Leu Val Asn Leu Ser Lys Val Gly Glu Tyr Trp
            260                 265                 270         
Trp Asn Ala Ile Leu Glu Gly Glu Glu Pro Ile Asp Ile Asp Lys Ile
        275                 280                 285             
Asn Lys Glu Arg Ser Met Ala Thr Val Asp Glu Glu Glu Gln Ala Val
    290                 295                 300                 
Leu Asp Arg Leu Thr Phe Asp Tyr His Gln Lys Leu Gln Gly Lys Pro
305                 310                 315                 320 
Gln Ser His Glu Leu Lys Val His Glu Met Leu Lys Lys Gly Trp Asp
                325                 330                 335     
Ala Glu Gly Ser Pro Phe Arg Gly Gln Arg Phe Asp Pro Ala Met Phe
            340                 345                 350         
Asn Ile Ser Pro Gly Ala Val Gln Phe
        355                 360     


<210> 7844
<211> 256
<212> PRT
<213> Homo sapiens

<400> 7844
Met Ala His Gly Ser Gln Glu Ala Glu Ala Pro Gly Ala Val Ala Gly
 1               5                  10                  15      
Ala Ala Glu Val Pro Arg Glu Pro Pro Ile Leu Pro Arg Ile Gln Glu
            20                  25                  30          
Gln Phe Gln Lys Asn Pro Asp Ser Tyr Asn Gly Ala Val Arg Glu Asn
        35                  40                  45              
Tyr Thr Trp Ser Gln Asp Tyr Thr Asp Leu Glu Val Arg Val Pro Val
    50                  55                  60                  
Pro Lys His Val Val Lys Gly Lys Gln Val Ser Val Ala Leu Ser Ser
65                  70                  75                  80  
Ser Ser Ile Arg Val Ala Met Leu Glu Glu Asn Gly Glu Arg Val Leu
                85                  90                  95      
Met Glu Gly Lys Leu Thr His Lys Ile Asn Thr Glu Ser Ser Leu Trp
            100                 105                 110         
Ser Leu Glu Pro Gly Lys Cys Val Leu Val Asn Leu Ser Lys Val Gly
        115                 120                 125             
Glu Tyr Trp Trp Asn Ala Ile Leu Glu Gly Glu Glu Pro Ile Asp Ile
    130                 135                 140                 
Asp Lys Ile Asn Lys Glu Arg Ser Met Ala Thr Val Asp Glu Glu Glu
145                 150                 155                 160 
Gln Ala Val Leu Asp Arg Leu Thr Phe Asp Tyr His Gln Lys Leu Gln
                165                 170                 175     
Gly Lys Pro Gln Ser His Glu Leu Lys Val His Glu Met Leu Lys Lys
            180                 185                 190         
Gly Trp Asp Ala Glu Gly Ser Pro Phe Arg Gly Gln Arg Phe Asp Pro
        195                 200                 205             
Ala Met Phe Asn Ile Ser Pro Gly Ala Val Gln Phe Asn Asp Gln Lys
    210                 215                 220                 
Glu Arg Lys Pro Ser Pro Val Gly Arg Gln Ser Leu Ile Leu Gly Cys
225                 230                 235                 240 
Pro Ser Trp Leu Pro Ala Phe Gln Gly Leu Ala Arg Leu Val Tyr Pro
                245                 250                 255     


<210> 7845
<211> 276
<212> PRT
<213> Homo sapiens

<400> 7845
Met Asp Asn Ala Gly Lys Glu Arg Glu Ala Val Gln Leu Met Ala Glu
 1               5                  10                  15      
Ala Glu Lys Arg Val Lys Ala Ser His Ser Phe Pro Arg Gly Leu Phe
            20                  25                  30          
Gly Gly Asn Thr Arg Ile Glu Glu Ala Cys Glu Met Tyr Thr Arg Ala
        35                  40                  45              
Ala Asn Met Phe Lys Met Ala Lys Asn Trp Ser Ala Ala Gly Asn Ala
    50                  55                  60                  
Phe Cys Gln Ala Ala Lys Leu His Met Gln Leu Gln Ser Lys His Asp
65                  70                  75                  80  
Ser Ala Thr Ser Phe Val Asp Ala Gly Asn Ala Tyr Lys Lys Ala Asp
                85                  90                  95      
Pro Gln Glu Ala Ile Asn Cys Leu Asn Ala Ala Ile Asp Ile Tyr Thr
            100                 105                 110         
Asp Met Gly Arg Phe Thr Ile Ala Ala Lys His His Ile Thr Ile Ala
        115                 120                 125             
Glu Ile Tyr Glu Thr Glu Leu Val Asp Ile Glu Lys Ala Ile Ala His
    130                 135                 140                 
Tyr Glu Gln Ser Ala Asp Tyr Tyr Lys Gly Glu Glu Ser Asn Ser Ser
145                 150                 155                 160 
Ala Asn Lys Cys Leu Leu Lys Val Ala Ala Tyr Ala Ala Gln Leu Glu
                165                 170                 175     
Gln Tyr Gln Lys Ala Ile Glu Ile Tyr Glu Gln Val Gly Ala Asn Thr
            180                 185                 190         
Met Asp Asn Pro Leu Leu Lys Tyr Ser Ala Lys Asp Tyr Phe Phe Lys
        195                 200                 205             
Ala Ala Leu Cys His Phe Ile Val Asp Glu Leu Asn Ala Lys Leu Ala
    210                 215                 220                 
Leu Glu Lys Tyr Glu Glu Met Phe Pro Ala Phe Thr Asp Ser Arg Glu
225                 230                 235                 240 
Cys Lys Leu Leu Lys Lys Leu Leu Glu Ala His Glu Glu Gln Asn Ser
                245                 250                 255     
Glu Glu Gln Ser Pro Ser Thr Lys Pro Trp Arg Arg Ser Asn Val Ala
            260                 265                 270         
Pro Ser Ser Ala
        275     


<210> 7846
<211> 298
<212> PRT
<213> Homo sapiens

<400> 7846
Met Asp Asn Ala Gly Lys Glu Arg Glu Ala Val Gln Leu Met Ala Glu
 1               5                  10                  15      
Ala Glu Lys Arg Val Lys Ala Ser His Ser Phe Leu Arg Gly Leu Phe
            20                  25                  30          
Gly Gly Asn Thr Arg Ile Glu Glu Ala Cys Glu Met Tyr Thr Arg Ala
        35                  40                  45              
Ala Asn Met Phe Lys Met Ala Lys Asn Trp Ser Ala Ala Gly Asn Ala
    50                  55                  60                  
Phe Cys Gln Ala Ala Lys Leu His Met Gln Leu Gln Ser Lys His Asp
65                  70                  75                  80  
Ser Ala Thr Ser Phe Val Asp Ala Gly Asn Ala Tyr Lys Lys Ala Asp
                85                  90                  95      
Pro Gln Glu Ala Ile Asn Cys Leu Asn Ala Ala Ile Asp Ile Tyr Thr
            100                 105                 110         
Asp Met Gly Arg Phe Thr Ile Ala Ala Lys His His Ile Thr Ile Ala
        115                 120                 125             
Glu Ile Tyr Glu Thr Glu Leu Val Asp Ile Glu Lys Ala Ile Ala His
    130                 135                 140                 
Tyr Glu Gln Ser Ala Asp Tyr Tyr Lys Gly Glu Glu Ser Asn Ser Ser
145                 150                 155                 160 
Ala Asn Lys Cys Leu Leu Lys Val Ala Ala Tyr Ala Ala Gln Leu Glu
                165                 170                 175     
Gln Tyr Gln Lys Ala Ile Glu Ile Tyr Glu Gln Val Gly Ala Asn Thr
            180                 185                 190         
Met Asp Asn Pro Leu Leu Lys Tyr Ser Ala Lys Asp Tyr Phe Phe Lys
        195                 200                 205             
Ala Ala Leu Cys His Phe Ile Val Asp Glu Leu Asn Ala Lys Leu Ala
    210                 215                 220                 
Leu Glu Lys Tyr Glu Glu Met Phe Pro Ala Phe Thr Asp Ser Arg Glu
225                 230                 235                 240 
Cys Lys Leu Leu Lys Lys Leu Leu Glu Ala His Glu Glu Gln Asn Ser
                245                 250                 255     
Glu Ala Tyr Thr Glu Ala Val Lys Glu Phe Asp Ser Ile Ser Arg Leu
            260                 265                 270         
Asp Gln Trp Leu Thr Thr Met Leu Leu Arg Ile Lys Lys Ser Ile Gln
        275                 280                 285             
Gly Asp Gly Glu Gly Asp Gly Asp Leu Lys
    290                 295             


<210> 7847
<211> 1224
<212> PRT
<213> Homo sapiens

<400> 7847
Met Asn Lys Met Leu Pro Ser Val Pro Ala Thr Ala Val Arg Val Ser
 1               5                  10                  15      
Cys Ser Gly Cys Lys Lys Ile Leu Gln Lys Gly Gln Thr Ala Tyr Gln
            20                  25                  30          
Arg Lys Gly Ser Thr Gln Leu Phe Cys Ser Thr Leu Cys Leu Thr Gly
        35                  40                  45              
Tyr Thr Val Pro Pro Ala Arg Pro Pro Pro Pro Leu Thr Lys Lys Thr
    50                  55                  60                  
Cys Ser Ser Cys Ser Lys Asp Ile Leu Asn Pro Lys Asp Val Ile Ser
65                  70                  75                  80  
Ala Gln Phe Glu Asn Thr Thr Thr Ser Lys Asp Phe Cys Ser Gln Ser
                85                  90                  95      
Cys Leu Ser Thr Tyr Glu Leu Lys Lys Lys Pro Ile Val Thr Ile Asn
            100                 105                 110         
Thr Asn Ser Ile Ser Thr Lys Cys Ser Met Cys Gln Lys Asn Ala Val
        115                 120                 125             
Ile Arg His Glu Val Asn Tyr Gln Asn Val Val His Lys Leu Cys Ser
    130                 135                 140                 
Asp Ala Cys Phe Ser Lys Phe Arg Ser Ala Asn Asn Leu Thr Met Asn
145                 150                 155                 160 
Cys Cys Glu Asn Cys Gly Gly Tyr Cys Tyr Ser Gly Ser Gly Gln Cys
                165                 170                 175     
His Met Leu Gln Ile Glu Gly Gln Ser Lys Lys Phe Cys Ser Ser Ser
            180                 185                 190         
Cys Ile Thr Ala Tyr Lys Gln Lys Ser Ala Lys Ile Thr Pro Cys Ala
        195                 200                 205             
Leu Cys Lys Ser Leu Arg Ser Ser Ala Glu Met Ile Glu Asn Thr Asn
    210                 215                 220                 
Ser Leu Gly Lys Thr Glu Leu Phe Cys Ser Val Asn Cys Leu Ser Ala
225                 230                 235                 240 
Tyr Arg Val Lys Met Val Thr Ser Ala Gly Val Gln Val Gln Cys Asn
                245                 250                 255     
Ser Cys Lys Thr Ser Ala Ile Pro Gln Tyr His Leu Ala Met Ser Asp
            260                 265                 270         
Gly Ser Ile Arg Asn Phe Cys Ser Tyr Ser Cys Val Val Ala Phe Gln
        275                 280                 285             
Asn Leu Phe Asn Lys Pro Thr Gly Met Asn Ser Ser Val Val Pro Leu
    290                 295                 300                 
Ser Gln Gly Gln Val Ile Val Ser Ile Pro Thr Gly Ser Thr Val Ser
305                 310                 315                 320 
Ala Gly Gly Gly Ser Thr Ser Ala Val Ser Pro Thr Ser Ile Ser Ser
                325                 330                 335     
Ser Ala Ala Ala Gly Leu Gln Arg Leu Ala Ala Gln Ser Gln His Val
            340                 345                 350         
Gly Phe Ala Arg Ser Val Val Lys Leu Lys Cys Gln His Cys Asn Arg
        355                 360                 365             
Leu Phe Ala Thr Lys Pro Glu Leu Leu Asp Tyr Lys Gly Lys Met Phe
    370                 375                 380                 
Gln Phe Cys Gly Lys Asn Cys Ser Asp Glu Tyr Lys Lys Ile Asn Asn
385                 390                 395                 400 
Val Met Ala Met Cys Glu Tyr Cys Lys Ile Glu Lys Ile Val Lys Glu
                405                 410                 415     
Thr Val Arg Phe Ser Gly Ala Asp Lys Ser Phe Cys Ser Glu Gly Cys
            420                 425                 430         
Lys Leu Leu Tyr Lys His Asp Leu Ala Lys Arg Trp Gly Asn His Cys
        435                 440                 445             
Lys Met Cys Ser Tyr Cys Leu Gln Thr Ser Pro Lys Leu Val Gln Asn
    450                 455                 460                 
Asn Leu Gly Gly Lys Val Glu Glu Phe Cys Cys Glu Glu Cys Met Ser
465                 470                 475                 480 
Lys Tyr Thr Val Leu Phe Tyr Gln Met Ala Lys Cys Asp Ala Cys Lys
                485                 490                 495     
Arg Gln Gly Lys Leu Ser Glu Ser Leu Lys Trp Arg Gly Glu Met Lys
            500                 505                 510         
His Phe Cys Asn Leu Leu Cys Ile Leu Met Phe Cys Asn Gln Gln Ser
        515                 520                 525             
Val Cys Asp Pro Pro Ser Gln Asn Asn Ala Ala Asn Ile Ser Met Val
    530                 535                 540                 
Gln Ala Ala Ser Ala Gly Pro Pro Ser Leu Arg Lys Asp Ser Thr Pro
545                 550                 555                 560 
Val Ile Ala Asn Val Val Ser Leu Ala Ser Ala Pro Ala Ala Gln Pro
                565                 570                 575     
Thr Val Asn Ser Asn Ser Val Leu Gln Gly Ala Val Pro Thr Val Thr
            580                 585                 590         
Ala Lys Ile Ile Gly Asp Ala Ser Thr Gln Thr Asp Ala Leu Lys Leu
        595                 600                 605             
Pro Pro Ser Gln Pro Pro Arg Leu Leu Lys Asn Lys Ala Leu Leu Cys
    610                 615                 620                 
Lys Pro Ile Thr Gln Thr Lys Ala Thr Ser Cys Lys Pro His Thr Gln
625                 630                 635                 640 
Asn Lys Glu Cys Gln Thr Glu Asp Thr Pro Ser Gln Pro Gln Ile Ile
                645                 650                 655     
Val Val Pro Val Pro Val Pro Val Phe Val Pro Ile Pro Leu His Leu
            660                 665                 670         
Tyr Thr Gln Tyr Ala Pro Val Pro Phe Gly Ile Pro Val Pro Met Pro
        675                 680                 685             
Val Pro Met Leu Ile Pro Ser Ser Met Asp Ser Glu Asp Lys Val Thr
    690                 695                 700                 
Glu Ser Ile Glu Asp Ile Lys Glu Lys Leu Pro Thr His Pro Phe Glu
705                 710                 715                 720 
Ala Asp Leu Leu Glu Met Ala Glu Met Ile Ala Glu Asp Glu Glu Lys
                725                 730                 735     
Lys Thr Leu Ser Gln Gly Glu Ser Gln Thr Ser Glu His Glu Leu Phe
            740                 745                 750         
Leu Asp Thr Lys Ile Phe Glu Lys Asp Gln Gly Ser Thr Tyr Ser Gly
        755                 760                 765             
Asp Leu Glu Ser Glu Ala Val Ser Thr Pro His Ser Trp Glu Glu Glu
    770                 775                 780                 
Leu Asn His Tyr Ala Leu Lys Ser Asn Ala Val Gln Glu Ala Asp Ser
785                 790                 795                 800 
Glu Leu Lys Gln Phe Ser Lys Gly Glu Thr Glu Gln Asp Leu Glu Ala
                805                 810                 815     
Asp Phe Pro Ser Asp Ser Phe Asp Pro Leu Asn Lys Gly Gln Gly Ile
            820                 825                 830         
Gln Ala Arg Ser Arg Thr Arg Arg Arg His Arg Asp Gly Phe Pro Gln
        835                 840                 845             
Pro Arg Arg Arg Gly Arg Lys Lys Ser Ile Val Ala Val Glu Pro Arg
    850                 855                 860                 
Ser Leu Ile Gln Gly Ala Phe Gln Gly Cys Ser Val Ser Gly Met Thr
865                 870                 875                 880 
Leu Lys Tyr Met Tyr Gly Val Asn Ala Trp Lys Asn Trp Val Gln Trp
                885                 890                 895     
Lys Asn Ala Lys Glu Glu Gln Gly Asp Leu Lys Cys Gly Gly Val Glu
            900                 905                 910         
Gln Ala Ser Ser Ser Pro Arg Ser Asp Pro Leu Gly Ser Thr Gln Asp
        915                 920                 925             
His Ala Leu Ser Gln Glu Ser Ser Glu Pro Gly Cys Arg Val Arg Ser
    930                 935                 940                 
Ile Lys Leu Lys Glu Asp Ile Leu Ser Cys Thr Phe Ala Glu Leu Ser
945                 950                 955                 960 
Leu Gly Leu Cys Gln Phe Ile Gln Glu Val Arg Arg Pro Asn Gly Glu
                965                 970                 975     
Lys Tyr Asp Pro Asp Ser Ile Leu Tyr Leu Cys Leu Gly Ile Gln Gln
            980                 985                 990         
Tyr Leu Phe Glu Asn Gly Arg Ile Asp Asn Ile Phe Thr Glu Pro Tyr
        995                 1000                1005            
Ser Arg Phe Met Ile Glu Leu Thr Lys Leu Leu Lys Ile Trp Glu Pro
    1010                1015                1020                
Thr Ile Leu Pro Asn Gly Tyr Met Phe Ser Arg Ile Glu Glu Glu His
1025                1030                1035                1040
Leu Trp Glu Cys Lys Gln Leu Gly Ala Tyr Ser Pro Ile Val Leu Leu
                1045                1050                1055    
Asn Thr Leu Leu Phe Phe Asn Thr Lys Tyr Phe Gln Leu Lys Asn Val
            1060                1065                1070        
Thr Glu His Leu Lys Leu Ser Phe Ala His Val Met Arg Arg Thr Arg
        1075                1080                1085            
Thr Leu Lys Tyr Ser Thr Lys Met Thr Tyr Leu Arg Phe Phe Pro Pro
    1090                1095                1100                
Leu Gln Lys Gln Glu Ser Glu Pro Asp Lys Leu Thr Val Gly Lys Arg
1105                1110                1115                1120
Lys Arg Asn Glu Asp Asp Glu Val Pro Val Gly Val Glu Met Ala Glu
                1125                1130                1135    
Asn Thr Asp Asn Pro Leu Arg Cys Pro Val Arg Leu Tyr Glu Phe Tyr
            1140                1145                1150        
Leu Ser Lys Cys Ser Glu Ser Val Lys Gln Arg Asn Asp Val Phe Tyr
        1155                1160                1165            
Leu Gln Pro Glu Arg Ser Cys Val Pro Asn Ser Pro Met Trp Tyr Ser
    1170                1175                1180                
Thr Phe Pro Ile Asp Pro Gly Thr Leu Asp Thr Met Leu Thr Arg Ile
1185                1190                1195                1200
Leu Met Val Arg Glu Val His Glu Glu Leu Ala Lys Ala Lys Ser Glu
                1205                1210                1215    
Asp Ser Asp Val Glu Leu Ser Asp
            1220                


<210> 7848
<211> 1509
<212> PRT
<213> Homo sapiens

<400> 7848
Met Asn Ser Pro Val Asp Pro Gly Ala Arg Gln Ala Leu Arg Lys Lys
 1               5                  10                  15      
Pro Pro Glu Arg Thr Pro Glu Asp Leu Asn Thr Ile Tyr Ser Tyr Leu
            20                  25                  30          
His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu Arg Leu
        35                  40                  45              
Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln Val Leu
    50                  55                  60                  
Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu Ser Gly
65                  70                  75                  80  
Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser Phe Gly
                85                  90                  95      
Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu Glu Pro
            100                 105                 110         
Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp Ser Ile
        115                 120                 125             
Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe Arg Lys
    130                 135                 140                 
Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val Glu Val
145                 150                 155                 160 
Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His Leu Thr
                165                 170                 175     
Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln Ser Gly
            180                 185                 190         
Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp Ile Tyr
        195                 200                 205             
Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg Leu Pro
    210                 215                 220                 
Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu Glu Ile
225                 230                 235                 240 
Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu Cys Leu
                245                 250                 255     
Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln Leu Leu
            260                 265                 270         
Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met Ser Val
        275                 280                 285             
Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu Gln Ala
    290                 295                 300                 
Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp Tyr Val
305                 310                 315                 320 
Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys Val Glu
                325                 330                 335     
Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu Asp Lys
            340                 345                 350         
Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys Gln Phe
        355                 360                 365             
Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His Val Glu
    370                 375                 380                 
Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met Val His
385                 390                 395                 400 
Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His Ile Val
                405                 410                 415     
Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu Glu His
            420                 425                 430         
Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr Tyr Arg
        435                 440                 445             
Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu Glu Trp
    450                 455                 460                 
Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val Leu Leu
465                 470                 475                 480 
Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala Met Thr
                485                 490                 495     
Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys Met Asn
            500                 505                 510         
Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala Lys Trp
        515                 520                 525             
Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu Gln Phe
    530                 535                 540                 
Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val Glu Gly
545                 550                 555                 560 
Val Glu Pro Gly Ser Glu Ala Ala Asp Ser Gly Leu Lys Arg Gly Asp
                565                 570                 575     
Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr Phe Met
            580                 585                 590         
Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu Thr Val
        595                 600                 605             
Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Pro Phe Arg Thr Glu Gln
    610                 615                 620                 
Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Lys Lys Lys Ser
625                 630                 635                 640 
Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln Thr Ser
                645                 650                 655     
Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Ala Ser Gly Gly
            660                 665                 670         
Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser Ile Leu
        675                 680                 685             
Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln Asp Asp
    690                 695                 700                 
Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile Met Pro
705                 710                 715                 720 
Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln Pro Thr
                725                 730                 735     
Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Ala Val Gly Phe Tyr Tyr
            740                 745                 750         
Ile Pro Asp Gln Val Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys
        755                 760                 765             
Tyr Ile Ile Ile Ser Lys Asp Thr Thr Ala Lys Glu Val Val Phe His
    770                 775                 780                 
Ala Val His Glu Phe Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu
785                 790                 795                 800 
Cys Glu Val Ser Val Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu
                805                 810                 815     
Pro Asp Gln Phe Ser Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg
            820                 825                 830         
Tyr Tyr Leu Lys Asn Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu
        835                 840                 845             
Asp Ala Gln Glu Leu Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu
    850                 855                 860                 
Ser Thr Ile Glu Val Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu
865                 870                 875                 880 
Phe Arg Asn Ile Glu Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu
                885                 890                 895     
Asn Ser Lys Thr Gly Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val
            900                 905                 910         
Asn Gln Glu Thr Phe Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn
        915                 920                 925             
Gln Leu Lys Arg Met Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu
    930                 935                 940                 
His Cys Arg Glu Cys Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser
945                 950                 955                 960 
Gly Leu Asn Leu Ala Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys
                965                 970                 975     
Leu Pro Ser Lys Tyr Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe
            980                 985                 990         
Asp Pro Ser Arg Asn Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln
        995                 1000                1005            
Ser Met Gln Pro Pro Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp
    1010                1015                1020                
Met Thr Phe Leu His Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val
1025                1030                1035                1040
Asn Phe Glu Lys Leu Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val
                1045                1050                1055    
Arg Met Thr Ser Ala Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg
            1060                1065                1070        
Lys Lys Arg Trp Arg Ser Leu Gly Ser Leu Ser Gln Gly Ser Thr Asn
        1075                1080                1085            
Ser Asn Met Leu Asp Val Gln Gly Gly Ala His Lys Lys Arg Ala Arg
    1090                1095                1100                
Arg Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr Glu Asp Ala Gln Met
1105                1110                1115                1120
Ala Arg Lys Val Lys Gln Tyr Leu Ser Ser Leu Asp Val Glu Thr Asp
                1125                1130                1135    
Glu Glu Lys Phe Gln Met Met Ser Leu Gln Trp Glu Pro Ala Tyr Gly
            1140                1145                1150        
Thr Leu Thr Lys Asn Leu Ser Glu Lys Arg Ser Ala Lys Ser Ser Glu
        1155                1160                1165            
Met Ser Pro Val Pro Met Arg Ser Ala Gly Gln Thr Thr Lys Ala His
    1170                1175                1180                
Leu His Gln Pro His Arg Val Ser Gln Val Leu Gln Val Pro Ala Val
1185                1190                1195                1200
Asn Leu His Pro Ile Arg Lys Lys Gly Gln Thr Lys Asp Pro Ala Leu
                1205                1210                1215    
Asn Thr Ser Leu Pro Gln Lys Val Leu Gly Thr Thr Glu Glu Ile Ser
            1220                1225                1230        
Gly Lys Lys His Thr Glu Asp Thr Ile Ser Val Ala Ser Ser Leu His
        1235                1240                1245            
Ser Ser Pro Pro Ala Ser Pro Gln Gly Ser Pro His Lys Gly Tyr Thr
    1250                1255                1260                
Leu Ile Pro Ser Ala Lys Ser Asp Asn Leu Ser Asp Ser Ser His Ser
1265                1270                1275                1280
Glu Ile Ser Ser Arg Ser Ser Ile Val Ser Asn Cys Ser Val Asp Ser
                1285                1290                1295    
Met Ser Ala Ala Leu Gln Asp Glu Arg Cys Ser Ser Gln Ala Leu Ala
            1300                1305                1310        
Val Pro Glu Ser Thr Gly Ala Leu Glu Lys Thr Glu His Ala Ser Gly
        1315                1320                1325            
Ile Gly Asp His Ser Gln His Gly Pro Gly Trp Thr Leu Leu Lys Pro
    1330                1335                1340                
Ser Leu Ile Lys Cys Leu Ala Val Ser Ser Ser Val Ser Asn Glu Glu
1345                1350                1355                1360
Ile Ser Gln Glu His Ile Ile Ile Glu Ala Ala Asp Ser Gly Arg Gly
                1365                1370                1375    
Ser Trp Thr Ser Cys Ser Ser Ser Ser His Asp Asn Phe Gln Ser Leu
            1380                1385                1390        
Pro Asn Pro Lys Ser Trp Asp Phe Leu Asn Ser Tyr Arg His Thr His
        1395                1400                1405            
Leu Asp Asp Pro Ile Ala Glu Val Glu Pro Thr Asp Ser Glu Pro Tyr
    1410                1415                1420                
Ser Cys Ser Lys Ser Cys Ser Arg Thr Cys Gly Gln Cys Lys Gly Ser
1425                1430                1435                1440
Leu Glu Arg Lys Ser Trp Thr Ser Ser Ser Ser Leu Ser Asp Thr Tyr
                1445                1450                1455    
Glu Pro Asn Tyr Gly Thr Val Lys Arg Arg Val Leu Glu Ser Thr Pro
            1460                1465                1470        
Ala Glu Ser Ser Glu Gly Leu Asp Pro Lys Asp Ala Thr Asp Pro Val
        1475                1480                1485            
Tyr Lys Thr Val Thr Ser Ser Thr Glu Lys Gly Leu Ile Glu Asn Glu
    1490                1495                1500                
Gln Val Ser Ala Val
1505                


<210> 7849
<211> 1204
<212> PRT
<213> Homo sapiens

<400> 7849
Met Ala Pro Thr Leu Phe Gln Lys Leu Phe Ser Lys Arg Thr Gly Leu
 1               5                  10                  15      
Gly Ala Pro Gly Arg Asp Ala Arg Asp Pro Asp Cys Gly Phe Ser Trp
            20                  25                  30          
Pro Leu Pro Glu Phe Asp Pro Ser Gln Ile Arg Leu Ile Val Tyr Gln
        35                  40                  45              
Asp Cys Glu Arg Arg Gly Arg Asn Val Leu Phe Asp Ser Ser Val Lys
    50                  55                  60                  
Arg Arg Asn Glu Asp Ile Ser Val Ser Asp Leu Asn Thr Ile Tyr Ser
65                  70                  75                  80  
Tyr Leu His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu
                85                  90                  95      
Arg Leu Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln
            100                 105                 110         
Val Leu Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu
        115                 120                 125             
Ser Gly Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser
    130                 135                 140                 
Phe Gly Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu
145                 150                 155                 160 
Glu Pro Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp
                165                 170                 175     
Ser Ile Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe
            180                 185                 190         
Arg Lys Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val
        195                 200                 205             
Glu Val Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His
    210                 215                 220                 
Leu Thr Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln
225                 230                 235                 240 
Ser Gly Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp
                245                 250                 255     
Ile Tyr Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg
            260                 265                 270         
Leu Pro Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu
        275                 280                 285             
Glu Ile Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu
    290                 295                 300                 
Cys Leu Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln
305                 310                 315                 320 
Leu Leu Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met
                325                 330                 335     
Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu
            340                 345                 350         
Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp
        355                 360                 365             
Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys
    370                 375                 380                 
Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu
385                 390                 395                 400 
Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys
                405                 410                 415     
Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His
            420                 425                 430         
Val Glu Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met
        435                 440                 445             
Val His Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His
    450                 455                 460                 
Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu
465                 470                 475                 480 
Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr
                485                 490                 495     
Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu
            500                 505                 510         
Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val
        515                 520                 525             
Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala
    530                 535                 540                 
Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys
545                 550                 555                 560 
Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala
                565                 570                 575     
Lys Trp Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu
            580                 585                 590         
Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val
        595                 600                 605             
Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly Leu Lys Arg
    610                 615                 620                 
Gly Asp Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr
625                 630                 635                 640 
Phe Met Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu
                645                 650                 655     
Thr Val Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu Phe Arg Thr
            660                 665                 670         
Glu Gln Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Glu Lys
        675                 680                 685             
Lys Ser Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln
    690                 695                 700                 
Thr Ser Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Val Ser
705                 710                 715                 720 
Gly Gly Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser
                725                 730                 735     
Ile Leu Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln
            740                 745                 750         
Asp Asp Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile
        755                 760                 765             
Met Pro Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln
    770                 775                 780                 
Pro Thr Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp
785                 790                 795                 800 
Gln Val Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile
                805                 810                 815     
Ile Ser Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His
            820                 825                 830         
Glu Phe Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val
        835                 840                 845             
Ser Val Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln
    850                 855                 860                 
Phe Ser Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu
865                 870                 875                 880 
Lys Asn Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln
                885                 890                 895     
Glu Leu Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile
            900                 905                 910         
Glu Val Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn
        915                 920                 925             
Ile Glu Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys
    930                 935                 940                 
Thr Gly Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu
945                 950                 955                 960 
Thr Phe Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys
                965                 970                 975     
Arg Met Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg
            980                 985                 990         
Glu Cys Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn
        995                 1000                1005            
Leu Ala Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser
    1010                1015                1020                
Lys Tyr Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser
1025                1030                1035                1040
Arg Asn Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Gln
                1045                1050                1055    
Pro Pro Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe
            1060                1065                1070        
Leu His Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu
        1075                1080                1085            
Lys Leu Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr
    1090                1095                1100                
Ser Ala Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg Ser Leu Ser
1105                1110                1115                1120
Gln Gly Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly Gly Ala His
                1125                1130                1135    
Lys Lys Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr
            1140                1145                1150        
Glu Asp Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu Ser Ser Leu
        1155                1160                1165            
Asp Val Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser Leu Gln Trp
    1170                1175                1180                
Glu Pro Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu Lys Arg Ser
1185                1190                1195                1200
Ala Lys Ile Ile
                


<210> 7850
<211> 1601
<212> PRT
<213> Homo sapiens

<400> 7850
Met Asn Ser Pro Val Asp Pro Gly Ala Arg Gln Ala Leu Arg Lys Lys
 1               5                  10                  15      
Pro Pro Glu Arg Thr Pro Glu Asp Leu Asn Thr Ile Tyr Ser Tyr Leu
            20                  25                  30          
His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu Arg Leu
        35                  40                  45              
Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln Val Leu
    50                  55                  60                  
Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu Ser Gly
65                  70                  75                  80  
Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser Phe Gly
                85                  90                  95      
Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu Glu Pro
            100                 105                 110         
Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp Ser Ile
        115                 120                 125             
Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe Arg Lys
    130                 135                 140                 
Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val Glu Val
145                 150                 155                 160 
Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His Leu Thr
                165                 170                 175     
Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln Ser Gly
            180                 185                 190         
Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp Ile Tyr
        195                 200                 205             
Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg Leu Pro
    210                 215                 220                 
Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu Glu Ile
225                 230                 235                 240 
Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu Cys Leu
                245                 250                 255     
Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln Leu Leu
            260                 265                 270         
Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met Ser Val
        275                 280                 285             
Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu Gln Ala
    290                 295                 300                 
Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp Tyr Val
305                 310                 315                 320 
Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys Val Glu
                325                 330                 335     
Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu Asp Lys
            340                 345                 350         
Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys Gln Phe
        355                 360                 365             
Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His Val Glu
    370                 375                 380                 
Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met Val His
385                 390                 395                 400 
Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His Ile Val
                405                 410                 415     
Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu Glu His
            420                 425                 430         
Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr Tyr Arg
        435                 440                 445             
Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu Glu Trp
    450                 455                 460                 
Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val Leu Leu
465                 470                 475                 480 
Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala Met Thr
                485                 490                 495     
Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys Met Asn
            500                 505                 510         
Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala Lys Trp
        515                 520                 525             
Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu Gln Phe
    530                 535                 540                 
Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val Glu Gly
545                 550                 555                 560 
Val Glu Pro Gly Ser Glu Ala Ala Asp Ser Gly Leu Lys Arg Gly Asp
                565                 570                 575     
Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr Phe Met
            580                 585                 590         
Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu Thr Val
        595                 600                 605             
Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Pro Phe Arg Thr Glu Gln
    610                 615                 620                 
Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Lys Lys Lys Ser
625                 630                 635                 640 
Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln Thr Ser
                645                 650                 655     
Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Ala Ser Gly Gly
            660                 665                 670         
Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser Ile Leu
        675                 680                 685             
Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln Asp Asp
    690                 695                 700                 
Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile Met Pro
705                 710                 715                 720 
Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln Pro Thr
                725                 730                 735     
Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp Gln Val
            740                 745                 750         
Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile Ile Ser
        755                 760                 765             
Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His Glu Phe
    770                 775                 780                 
Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val Ser Val
785                 790                 795                 800 
Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln Phe Ser
                805                 810                 815     
Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu Lys Asn
            820                 825                 830         
Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln Glu Leu
        835                 840                 845             
Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile Glu Val
    850                 855                 860                 
Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn Ile Glu
865                 870                 875                 880 
Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys Thr Gly
                885                 890                 895     
Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu Thr Phe
            900                 905                 910         
Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys Arg Met
        915                 920                 925             
Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg Glu Cys
    930                 935                 940                 
Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn Leu Ala
945                 950                 955                 960 
Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser Lys Tyr
                965                 970                 975     
Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser Arg Asn
            980                 985                 990         
Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Gln Pro Pro
        995                 1000                1005            
Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe Leu His
    1010                1015                1020                
Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu Lys Leu
1025                1030                1035                1040
Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr Ser Ala
                1045                1050                1055    
Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg Ser Leu Ser Gln Gly
            1060                1065                1070        
Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly Gly Ala His Lys Lys
        1075                1080                1085            
Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr Glu Asp
    1090                1095                1100                
Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu Ser Ser Leu Asp Val
1105                1110                1115                1120
Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser Leu Gln Trp Glu Pro
                1125                1130                1135    
Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu Lys Arg Ser Ala Lys
            1140                1145                1150        
Ser Ser Glu Met Ser Pro Val Pro Met Arg Ser Ala Gly Gln Thr Thr
        1155                1160                1165            
Lys Ala His Leu His Gln Pro His Arg Val Ser Gln Val Leu Gln Val
    1170                1175                1180                
Pro Ala Val Asn Leu His Pro Ile Arg Lys Lys Gly Gln Thr Lys Asp
1185                1190                1195                1200
Pro Ala Leu Asn Thr Ser Leu Pro Gln Lys Val Leu Gly Thr Thr Glu
                1205                1210                1215    
Glu Ile Ser Gly Lys Lys His Thr Glu Asp Thr Ile Ser Val Ala Ser
            1220                1225                1230        
Ser Leu His Ser Ser Pro Pro Ala Ser Pro Gln Gly Ser Pro His Lys
        1235                1240                1245            
Gly Tyr Thr Leu Ile Pro Ser Ala Lys Ser Asp Asn Leu Ser Asp Ser
    1250                1255                1260                
Ser His Ser Glu Ile Ser Ser Arg Ser Ser Ile Val Ser Asn Cys Ser
1265                1270                1275                1280
Val Asp Ser Met Ser Ala Ala Leu Gln Asp Glu Arg Cys Ser Ser Gln
                1285                1290                1295    
Ala Leu Ala Val Pro Glu Ser Thr Gly Ala Leu Glu Lys Thr Glu His
            1300                1305                1310        
Ala Ser Gly Ile Gly Asp His Ser Gln His Gly Pro Gly Trp Thr Leu
        1315                1320                1325            
Leu Lys Pro Ser Leu Ile Lys Cys Leu Ala Val Ser Ser Ser Val Ser
    1330                1335                1340                
Asn Glu Glu Ile Ser Gln Glu His Ile Ile Ile Glu Ala Ala Asp Ser
1345                1350                1355                1360
Gly Arg Gly Ser Trp Thr Ser Cys Ser Ser Ser Ser His Asp Asn Phe
                1365                1370                1375    
Gln Ser Leu Pro Asn Pro Lys Ser Trp Asp Phe Leu Asn Ser Tyr Arg
            1380                1385                1390        
His Thr His Leu Asp Asp Pro Ile Ala Glu Val Glu Pro Thr Asp Ser
        1395                1400                1405            
Glu Pro Tyr Ser Cys Ser Lys Ser Cys Ser Arg Thr Cys Gly Gln Cys
    1410                1415                1420                
Lys Gly Ser Leu Glu Arg Lys Ser Trp Thr Ser Ser Ser Ser Leu Ser
1425                1430                1435                1440
Asp Thr Tyr Glu Pro Asn Tyr Gly Thr Val Lys Arg Arg Val Leu Glu
                1445                1450                1455    
Ser Thr Pro Ala Glu Ser Ser Glu Gly Leu Asp Pro Lys Asp Ala Thr
            1460                1465                1470        
Asp Pro Val Tyr Lys Thr Val Thr Ser Ser Thr Glu Lys Gly Leu Ile
        1475                1480                1485            
Val Tyr Cys Val Thr Ser Pro Lys Lys Asp Asp Arg Tyr Arg Glu Pro
    1490                1495                1500                
Pro Pro Thr Pro Pro Gly Tyr Leu Gly Ile Ser Leu Ala Asp Leu Lys
1505                1510                1515                1520
Glu Gly Pro His Thr His Leu Lys Pro Pro Asp Tyr Ser Val Ala Val
                1525                1530                1535    
Gln Arg Ser Lys Met Met His Asn Ser Leu Ser Arg Leu Pro Pro Ala
            1540                1545                1550        
Ser Leu Ser Ser Asn Leu Val Ala Cys Val Pro Ser Lys Ile Val Thr
        1555                1560                1565            
Gln Pro Gln Arg His Asn Leu Gln Pro Phe His Pro Lys Leu Gly Asp
    1570                1575                1580                
Val Thr Asp Ala Asp Ser Glu Ala Asp Glu Asn Glu Gln Val Ser Ala
1585                1590                1595                1600
Val
    


<210> 7851
<211> 1391
<212> PRT
<213> Homo sapiens

<400> 7851
Met Asn Ser Pro Val Asp Pro Gly Ala Arg Gln Ala Leu Arg Lys Lys
 1               5                  10                  15      
Pro Pro Glu Arg Thr Pro Glu Asp Leu Asn Thr Ile Tyr Ser Tyr Leu
            20                  25                  30          
His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu Arg Leu
        35                  40                  45              
Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln Val Leu
    50                  55                  60                  
Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu Ser Gly
65                  70                  75                  80  
Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser Phe Gly
                85                  90                  95      
Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu Glu Pro
            100                 105                 110         
Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp Ser Ile
        115                 120                 125             
Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe Arg Lys
    130                 135                 140                 
Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val Glu Val
145                 150                 155                 160 
Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His Leu Thr
                165                 170                 175     
Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln Ser Gly
            180                 185                 190         
Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp Ile Tyr
        195                 200                 205             
Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg Leu Pro
    210                 215                 220                 
Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu Glu Ile
225                 230                 235                 240 
Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu Cys Leu
                245                 250                 255     
Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln Leu Leu
            260                 265                 270         
Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met Ser Val
        275                 280                 285             
Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu Gln Ala
    290                 295                 300                 
Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp Tyr Val
305                 310                 315                 320 
Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys Val Glu
                325                 330                 335     
Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu Asp Lys
            340                 345                 350         
Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys Gln Phe
        355                 360                 365             
Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His Val Glu
    370                 375                 380                 
Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met Val His
385                 390                 395                 400 
Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His Ile Val
                405                 410                 415     
Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu Glu His
            420                 425                 430         
Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr Tyr Arg
        435                 440                 445             
Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu Glu Trp
    450                 455                 460                 
Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val Leu Leu
465                 470                 475                 480 
Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala Met Thr
                485                 490                 495     
Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys Met Asn
            500                 505                 510         
Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala Lys Trp
        515                 520                 525             
Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu Gln Phe
    530                 535                 540                 
Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val Glu Gly
545                 550                 555                 560 
Val Glu Pro Gly Ser Glu Ala Ala Asp Ser Gly Leu Lys Arg Gly Asp
                565                 570                 575     
Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr Phe Met
            580                 585                 590         
Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu Thr Val
        595                 600                 605             
Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Pro Phe Arg Thr Glu Gln
    610                 615                 620                 
Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Lys Lys Lys Ser
625                 630                 635                 640 
Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln Thr Ser
                645                 650                 655     
Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Ala Ser Gly Gly
            660                 665                 670         
Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser Ile Leu
        675                 680                 685             
Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln Asp Asp
    690                 695                 700                 
Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile Met Pro
705                 710                 715                 720 
Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln Pro Thr
                725                 730                 735     
Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp Gln Val
            740                 745                 750         
Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile Ile Ser
        755                 760                 765             
Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His Glu Phe
    770                 775                 780                 
Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val Ser Val
785                 790                 795                 800 
Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln Phe Ser
                805                 810                 815     
Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu Lys Asn
            820                 825                 830         
Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln Glu Leu
        835                 840                 845             
Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile Glu Val
    850                 855                 860                 
Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn Ile Glu
865                 870                 875                 880 
Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys Thr Gly
                885                 890                 895     
Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu Thr Phe
            900                 905                 910         
Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys Arg Met
        915                 920                 925             
Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg Glu Cys
    930                 935                 940                 
Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn Leu Ala
945                 950                 955                 960 
Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser Lys Tyr
                965                 970                 975     
Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser Arg Asn
            980                 985                 990         
Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Gln Pro Pro
        995                 1000                1005            
Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe Leu His
    1010                1015                1020                
Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu Lys Leu
1025                1030                1035                1040
Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr Ser Ala
                1045                1050                1055    
Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg Ser Leu Ser Gln Gly
            1060                1065                1070        
Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly Gly Ala His Lys Lys
        1075                1080                1085            
Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr Glu Asp
    1090                1095                1100                
Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu Ser Ser Leu Asp Val
1105                1110                1115                1120
Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser Leu Gln Trp Glu Pro
                1125                1130                1135    
Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu Lys Arg Ser Ala Lys
            1140                1145                1150        
Ser Ser Glu Met Ser Pro Val Pro Met Arg Ser Ala Gly Gln Thr Thr
        1155                1160                1165            
Lys Ala His Leu His Gln Pro His Arg Val Ser Gln Val Leu Gln Val
    1170                1175                1180                
Pro Ala Val Asn Leu His Pro Ile Arg Lys Lys Gly Gln Thr Lys Asp
1185                1190                1195                1200
Pro Ala Leu Asn Thr Ser Leu Pro Gln Lys Val Leu Gly Thr Thr Glu
                1205                1210                1215    
Glu Ile Ser Gly Lys Lys His Thr Glu Asp Thr Ile Ser Val Ala Ser
            1220                1225                1230        
Ser Leu His Ser Ser Pro Pro Ala Ser Pro Gln Gly Ser Pro His Lys
        1235                1240                1245            
Val Gly Ser Ile Ile Ser Asp His Ser Ser Lys Ile Ser Gly Gln Ser
    1250                1255                1260                
Cys Pro Gly Ile Gly Gly Ala Tyr Leu Gln Lys Lys Ile Leu Gln Ile
1265                1270                1275                1280
Thr Arg Ser Thr Ala Lys Arg Thr Asp Ser Thr Glu Lys Ala Thr Glu
                1285                1290                1295    
Glu Asn Arg Asp Arg Thr Ser Cys Glu Asn Thr Thr Arg Lys Arg Met
            1300                1305                1310        
Thr Ser Pro Phe Arg Arg Leu Arg Glu Arg Met Leu Ser Arg Glu Arg
        1315                1320                1325            
Leu Val Asn Ser Gln Lys Glu Asp Thr Asp His Asn Gln Ala Thr Glu
    1330                1335                1340                
Ser Cys Glu Lys Val Lys Asp Val Gly Ser Asn Ile Lys Asp Glu Lys
1345                1350                1355                1360
Gly Ser Ala Ile Phe Asn Ser Asn Ser Gln Gly Asn Ser Asn Thr Leu
                1365                1370                1375    
Asn Cys Phe Tyr Thr Arg Phe Lys Ser Lys Arg Arg Lys Thr Leu
            1380                1385                1390    


<210> 7852
<211> 1113
<212> PRT
<213> Homo sapiens

<400> 7852
Met Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val
 1               5                  10                  15      
Glu Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser
            20                  25                  30          
Trp Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly
        35                  40                  45              
Lys Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr
    50                  55                  60                  
Leu Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp
65                  70                  75                  80  
Cys Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn
                85                  90                  95      
His Val Glu Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val
            100                 105                 110         
Met Val His Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly
        115                 120                 125             
His Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile
    130                 135                 140                 
Glu Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu
145                 150                 155                 160 
Thr Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu
                165                 170                 175     
Leu Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile
            180                 185                 190         
Val Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro
        195                 200                 205             
Ala Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr
    210                 215                 220                 
Lys Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala Cys Leu Gln Arg
225                 230                 235                 240 
Leu Met Glu Thr Gly Cys Ala Ala Lys Gly Phe Pro Arg Val Pro Ser
                245                 250                 255     
Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val
            260                 265                 270         
Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly Leu Lys Arg
        275                 280                 285             
Gly Asp Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr
    290                 295                 300                 
Phe Met Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu
305                 310                 315                 320 
Thr Val Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu Phe Arg Thr
                325                 330                 335     
Glu Gln Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Glu Lys
            340                 345                 350         
Lys Ser Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln
        355                 360                 365             
Ala Ser Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Val Ser
    370                 375                 380                 
Gly Gly Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser
385                 390                 395                 400 
Ile Leu Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln
                405                 410                 415     
Asp Asp Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile
            420                 425                 430         
Met Pro Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln
        435                 440                 445             
Pro Thr Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp
    450                 455                 460                 
Gln Val Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile
465                 470                 475                 480 
Ile Ser Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His
                485                 490                 495     
Glu Phe Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val
            500                 505                 510         
Ser Val Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln
        515                 520                 525             
Phe Ser Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu
    530                 535                 540                 
Lys Asn Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln
545                 550                 555                 560 
Glu Leu Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile
                565                 570                 575     
Glu Val Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn
            580                 585                 590         
Ile Glu Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys
        595                 600                 605             
Thr Gly Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu
    610                 615                 620                 
Thr Phe Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys
625                 630                 635                 640 
Arg Met Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg
                645                 650                 655     
Glu Cys Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn
            660                 665                 670         
Leu Ala Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser
        675                 680                 685             
Lys Tyr Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser
    690                 695                 700                 
Arg Asn Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Arg
705                 710                 715                 720 
Pro Pro Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe
                725                 730                 735     
Leu His Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu
            740                 745                 750         
Lys Leu Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr
        755                 760                 765             
Ser Ala Asn Met Asp Pro Ala Met Met Phe Arg Gln Gly Lys Lys Arg
    770                 775                 780                 
Trp Arg Ser Leu Gly Ser Leu Ser Gln Gly Ser Thr Asn Ser Asn Met
785                 790                 795                 800 
Leu Asp Val Gln Gly Gly Ala His Lys Lys Arg Ala Arg Arg Ser Ser
                805                 810                 815     
Leu Leu Asn Ala Lys Lys Leu Tyr Glu Asp Ala Gln Met Ala Arg Lys
            820                 825                 830         
Val Lys Gln Tyr Leu Ser Ser Leu Asp Val Glu Thr Asp Glu Glu Lys
        835                 840                 845             
Phe Gln Met Met Ser Leu Gln Trp Glu Pro Ala Tyr Gly Thr Leu Thr
    850                 855                 860                 
Lys Asn Leu Ser Glu Lys Arg Ser Ala Lys Ser Ser Glu Met Ser Pro
865                 870                 875                 880 
Val Pro Met Arg Ser Ala Gly Gln Thr Thr Lys Ala His Leu His Gln
                885                 890                 895     
Pro His Arg Val Ser Gln Val Leu Gln Val Pro Ala Val Asn Leu His
            900                 905                 910         
Pro Ile Arg Lys Lys Gly Gln Thr Lys Asp Pro Ala Leu Asn Thr Ser
        915                 920                 925             
Leu Pro Gln Lys Val Leu Gly Thr Thr Glu Glu Ile Ser Gly Lys Lys
    930                 935                 940                 
His Thr Glu Asp Thr Ile Ser Val Ala Ser Ser Leu His Ser Ser Pro
945                 950                 955                 960 
Pro Ala Ser Pro Gln Gly Ser Pro His Lys Val Gly Ser Ile Ile Ser
                965                 970                 975     
Asp His Ser Ser Lys Ile Ser Gly Gln Ser Cys Pro Gly Ile Gly Gly
            980                 985                 990         
Ala Tyr Leu Gln Lys Lys Ile Leu Gln Ile Thr Arg Ser Thr Ala Lys
        995                 1000                1005            
Arg Thr Asp Ser Thr Glu Lys Ala Thr Glu Glu Asn Arg Asp Arg Thr
    1010                1015                1020                
Ser Cys Glu Asn Thr Thr Arg Lys Arg Met Thr Ser Pro Phe Arg Arg
1025                1030                1035                1040
Leu Arg Glu Arg Met Leu Ser Arg Glu Arg Leu Val Asn Ser Gln Lys
                1045                1050                1055    
Glu Asp Thr Asp His Asn Gln Ala Thr Glu Ser Cys Glu Lys Val Lys
            1060                1065                1070        
Asp Val Gly Ser Asn Ile Lys Asp Glu Lys Gly Ser Ala Ile Phe Asn
        1075                1080                1085            
Ser Asn Ser Gln Gly Asn Ser Asn Thr Leu Asn Cys Phe Tyr Thr Arg
    1090                1095                1100                
Phe Lys Ser Lys Arg Arg Lys Thr Leu
1105                1110            


<210> 7853
<211> 1384
<212> PRT
<213> Homo sapiens

<400> 7853
Glu Leu Trp Ser Leu Arg Thr Met Asp Ala Leu Asn Arg Asn Gln Ile
 1               5                  10                  15      
Gly Pro Gly Cys Gln Thr Gln Thr Met Val Gln Lys Gly Pro Leu Asp
            20                  25                  30          
Leu Ile Glu Thr Gly Lys Gly Leu Lys Val Gln Thr Asp Lys Pro His
        35                  40                  45              
Leu Val Ser Leu Gly Ser Gly Arg Leu Ser Thr Ala Ile Thr Leu Leu
    50                  55                  60                  
Pro Leu Glu Glu Gly Arg Thr Val Ile Gly Ser Ala Ala Arg Asp Ile
65                  70                  75                  80  
Ser Leu Gln Gly Pro Gly Leu Ala Pro Glu His Cys Tyr Ile Glu Asn
                85                  90                  95      
Leu Arg Gly Thr Leu Thr Leu Tyr Pro Cys Gly Asn Ala Cys Thr Ile
            100                 105                 110         
Asp Gly Leu Pro Val Arg Gln Pro Thr Arg Leu Thr Gln Gly Cys Met
        115                 120                 125             
Leu Cys Leu Gly Gln Ser Thr Phe Leu Arg Phe Asn His Pro Ala Glu
    130                 135                 140                 
Ala Lys Trp Met Lys Ser Met Ile Pro Ala Gly Gly Arg Ala Pro Gly
145                 150                 155                 160 
Pro Pro Tyr Ser Pro Val Pro Ala Glu Ser Glu Ser Leu Val Asn Gly
                165                 170                 175     
Asn His Thr Pro Gln Thr Ala Thr Arg Gly Pro Ser Ala Cys Ala Ser
            180                 185                 190         
His Ser Ser Leu Val Ser Ser Ile Glu Lys Asp Leu Gln Glu Ile Met
        195                 200                 205             
Asp Ser Leu Val Leu Glu Glu Pro Gly Ala Ala Gly Lys Lys Pro Ala
    210                 215                 220                 
Ala Thr Ser Pro Leu Ser Pro Met Ala Asn Gly Gly Arg Tyr Leu Leu
225                 230                 235                 240 
Ser Pro Pro Thr Ser Pro Gly Ala Met Ser Val Gly Ser Ser Tyr Glu
                245                 250                 255     
Asn Thr Ser Pro Ala Phe Ser Pro Leu Ser Ser Pro Ala Ser Ser Gly
            260                 265                 270         
Ser Cys Ala Ser His Ser Pro Ser Gly Gln Glu Pro Gly Pro Ser Val
        275                 280                 285             
Pro Pro Leu Val Pro Ala Arg Ser Ser Ser Tyr His Leu Ala Leu Gln
    290                 295                 300                 
Pro Pro Gln Ser Arg Pro Ser Gly Ala Arg Ser Glu Ser Pro Arg Leu
305                 310                 315                 320 
Ser Arg Lys Gly Gly His Glu Arg Pro Pro Ser Pro Gly Leu Arg Gly
                325                 330                 335     
Leu Leu Thr Asp Ser Pro Ala Ala Thr Val Leu Ala Glu Ala Arg Arg
            340                 345                 350         
Ala Thr Glu Ser Pro Arg Leu Gly Gly Gln Leu Pro Val Val Ala Ile
        355                 360                 365             
Ser Leu Ser Glu Tyr Pro Ala Ser Gly Ala Leu Ser Gln Pro Thr Ser
    370                 375                 380                 
Ile Pro Gly Ser Pro Lys Phe Gln Pro Pro Val Pro Ala Pro Arg Asn
385                 390                 395                 400 
Lys Ile Gly Thr Leu Gln Asp Arg Pro Pro Ser Pro Phe Arg Glu Pro
                405                 410                 415     
Pro Gly Ser Glu Arg Val Leu Thr Thr Ser Pro Ser Arg Gln Leu Val
            420                 425                 430         
Gly Arg Thr Phe Ser Asp Gly Leu Ala Thr Arg Thr Leu Gln Pro Pro
        435                 440                 445             
Glu Ser Pro Arg Leu Gly Arg Arg Gly Leu Asp Ser Met Arg Glu Leu
    450                 455                 460                 
Pro Pro Leu Ser Pro Ser Leu Ser Arg Arg Ala Leu Ser Pro Leu Pro
465                 470                 475                 480 
Thr Arg Thr Thr Pro Asp Pro Lys Leu Asn Arg Glu Val Ala Glu Ser
                485                 490                 495     
Pro Arg Pro Arg Arg Trp Ala Ala His Gly Ala Ser Pro Glu Asp Phe
            500                 505                 510         
Ser Leu Thr Leu Gly Ala Arg Gly Arg Arg Thr Arg Ser Pro Ser Pro
        515                 520                 525             
Thr Leu Gly Glu Ser Leu Ala Pro His Lys Gly Ser Phe Ser Gly Arg
    530                 535                 540                 
Leu Ser Pro Ala Tyr Ser Leu Gly Ser Leu Thr Gly Ala Ser Pro Cys
545                 550                 555                 560 
Gln Ser Pro Cys Val Gln Arg Lys Leu Ser Ser Gly Asp Leu Arg Val
                565                 570                 575     
Pro Val Thr Arg Glu Arg Lys Asn Ser Ile Thr Glu Ile Ser Asp Asn
            580                 585                 590         
Glu Asp Asp Leu Leu Glu Tyr His Arg Arg Gln Arg Gln Glu Arg Leu
        595                 600                 605             
Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln Arg Leu Glu Thr Ile
    610                 615                 620                 
Leu Asn Leu Cys Ala Glu Tyr Ser Arg Ala Asp Gly Gly Pro Glu Ala
625                 630                 635                 640 
Gly Glu Leu Pro Ser Ile Gly Glu Ala Thr Ala Ala Leu Ala Leu Ala
                645                 650                 655     
Gly Arg Arg Pro Ser Arg Gly Leu Ala Gly Ala Ser Gly Arg Ser Ser
            660                 665                 670         
Glu Glu Pro Gly Val Ala Thr Gln Arg Leu Trp Glu Ser Met Glu Arg
        675                 680                 685             
Ser Asp Glu Glu Asn Leu Lys Glu Glu Cys Ser Ser Thr Glu Ser Thr
    690                 695                 700                 
Gln Gln Glu His Glu Asp Ala Pro Ser Thr Lys Leu Gln Gly Glu Val
705                 710                 715                 720 
Leu Ala Leu Glu Glu Glu Arg Ala Gln Val Leu Gly His Val Glu Gln
                725                 730                 735     
Leu Lys Val Arg Val Lys Glu Leu Glu Gln Gln Leu Gln Glu Ser Ala
            740                 745                 750         
Arg Glu Ala Glu Met Glu Arg Ala Leu Leu Gln Gly Glu Arg Glu Ala
        755                 760                 765             
Glu Arg Ala Leu Leu Gln Lys Glu Gln Lys Ala Val Asp Gln Leu Gln
    770                 775                 780                 
Glu Lys Leu Val Ala Leu Glu Thr Gly Ile Gln Lys Glu Arg Asp Lys
785                 790                 795                 800 
Glu Ala Glu Ala Leu Glu Thr Glu Thr Lys Leu Phe Glu Asp Leu Glu
                805                 810                 815     
Phe Gln Gln Leu Glu Arg Glu Ser Arg Val Glu Glu Glu Arg Glu Leu
            820                 825                 830         
Ala Gly Gln Gly Leu Leu Arg Ser Lys Ala Glu Leu Leu Arg Ser Ile
        835                 840                 845             
Ala Lys Arg Lys Glu Arg Leu Ala Ile Leu Asp Ser Gln Ala Gly Gln
    850                 855                 860                 
Ile Arg Ala Gln Ala Val Gln Glu Ser Glu Arg Leu Ala Arg Asp Lys
865                 870                 875                 880 
Asn Ala Ser Leu Gln Leu Leu Gln Lys Glu Lys Glu Lys Leu Thr Val
                885                 890                 895     
Leu Glu Arg Arg Tyr His Ser Leu Thr Gly Gly Arg Pro Phe Pro Lys
            900                 905                 910         
Thr Thr Ser Thr Leu Lys Glu Met Glu Lys Leu Leu Leu Pro Ala Val
        915                 920                 925             
Asp Leu Glu Gln Trp Tyr Gln Glu Leu Met Ala Gly Leu Gly Thr Gly
    930                 935                 940                 
Pro Ala Ala Ala Ser Pro His Ser Ser Pro Pro Pro Leu Pro Ala Lys
945                 950                 955                 960 
Ala Ser Arg Gln Leu Gln Val Tyr Arg Ser Lys Met Asp Gly Glu Ala
                965                 970                 975     
Thr Ser Pro Leu Pro Arg Thr Arg Ser Gly Pro Leu Pro Ser Ser Ser
            980                 985                 990         
Gly Ser Ser Ser Ser Ser Ser Gln Leu Ser Val Ala Thr Leu Gly Arg
        995                 1000                1005            
Ser Pro Ser Pro Lys Ser Ala Leu Leu Thr Gln Asn Gly Thr Gly Ser
    1010                1015                1020                
Leu Pro Arg Asn Leu Ala Ala Thr Leu Gln Asp Ile Glu Thr Lys Arg
1025                1030                1035                1040
Gln Leu Ala Leu Gln Gln Lys Gly Gln Gln Val Ile Glu Glu Gln Arg
                1045                1050                1055    
Arg Arg Leu Ala Glu Leu Lys Gln Lys Ala Ala Ala Glu Ala Gln Cys
            1060                1065                1070        
Gln Trp Asp Ala Leu His Gly Ala Ala Pro Phe Pro Ala Gly Pro Ser
        1075                1080                1085            
Gly Phe Pro Pro Leu Met His His Ser Ile Leu His His Leu Pro Ala
    1090                1095                1100                
Gly Arg Glu Arg Gly Glu Glu Gly Glu His Ala Tyr Asp Thr Leu Ser
1105                1110                1115                1120
Leu Glu Ser Ser Asp Ser Met Glu Thr Ser Ile Ser Thr Gly Gly Asn
                1125                1130                1135    
Ser Ala Cys Ser Pro Asp Asn Met Ser Ser Ala Ser Gly Leu Asp Met
            1140                1145                1150        
Gly Lys Ile Glu Glu Met Glu Lys Met Leu Lys Glu Ala His Ala Glu
        1155                1160                1165            
Lys Asn Arg Leu Met Glu Ser Arg Glu Arg Glu Met Glu Leu Arg Arg
    1170                1175                1180                
Gln Ala Leu Glu Glu Glu Arg Arg Arg Arg Glu Gln Val Glu Arg Arg
1185                1190                1195                1200
Leu Gln Ser Glu Ser Ala Arg Arg Gln Gln Leu Val Glu Lys Glu Val
                1205                1210                1215    
Lys Met Arg Glu Lys Gln Phe Ser Gln Ala Arg Pro Leu Thr Arg Tyr
            1220                1225                1230        
Leu Pro Ile Arg Lys Glu Asp Phe Asp Leu Lys Thr His Ile Glu Ser
        1235                1240                1245            
Ser Gly His Gly Val Asp Thr Cys Leu His Val Val Leu Ser Ser Lys
    1250                1255                1260                
Val Cys Arg Gly Tyr Leu Val Lys Met Gly Gly Lys Ile Lys Ser Trp
1265                1270                1275                1280
Lys Lys Arg Trp Phe Val Phe Asp Arg Leu Lys Arg Thr Leu Ser Tyr
                1285                1290                1295    
Tyr Val Asp Lys His Glu Thr Lys Leu Lys Gly Val Ile Tyr Phe Gln
            1300                1305                1310        
Ala Ile Glu Glu Val Tyr Tyr Asp His Leu Arg Ser Ala Ala Lys Lys
        1315                1320                1325            
Arg Phe Phe Arg Phe Thr Met Val Thr Glu Ser Pro Asn Pro Ala Leu
    1330                1335                1340                
Thr Phe Cys Val Lys Thr His Asp Arg Leu Tyr Tyr Met Val Ala Pro
1345                1350                1355                1360
Ser Ala Glu Ala Met Arg Ile Trp Met Asp Val Ile Val Thr Gly Ala
                1365                1370                1375    
Glu Gly Tyr Thr Gln Phe Met Asn
            1380                


<210> 7854
<211> 1326
<212> PRT
<213> Homo sapiens

<400> 7854
Glu Leu Trp Ser Leu Arg Thr Met Asp Ala Leu Asn Arg Asn Gln Ile
 1               5                  10                  15      
Gly Pro Gly Cys Gln Thr Gln Thr Met Val Gln Lys Gly Pro Leu Asp
            20                  25                  30          
Leu Ile Glu Lys Gly Lys Gly Leu Lys Val Gln Thr Asp Lys Pro His
        35                  40                  45              
Leu Val Ser Leu Gly Ser Gly Arg Leu Ser Thr Ala Ile Thr Leu Leu
    50                  55                  60                  
Pro Val Glu Glu Gly Arg Thr Val Ile Gly Ser Ala Ala Arg Asp Ile
65                  70                  75                  80  
Ser Ile Gln Gly Pro Gly Leu Ala Pro Glu His Cys Tyr Ile Glu Asn
                85                  90                  95      
Leu Gly Gly Thr Leu Thr Leu Tyr Pro Cys Gly Asn Ala Cys Thr Ile
            100                 105                 110         
Asp Gly Leu Pro Val Arg Gln Pro Thr Arg Leu Thr Gln Gly Cys Met
        115                 120                 125             
Leu Cys Leu Gly Gln Ser Thr Phe Leu Arg Phe Asn His Pro Ala Glu
    130                 135                 140                 
Ala Lys Trp Met Lys Ser Met Ile Pro Ala Gly Gly Arg Ala Pro Gly
145                 150                 155                 160 
Pro Pro Tyr Ser Pro Val Pro Ala Glu Ser Glu Ser Leu Val Asn Gly
                165                 170                 175     
Asn His Thr Pro Gln Thr Ala Thr Arg Gly Pro Ser Ala Cys Ala Ser
            180                 185                 190         
His Ser Ser Leu Val Ser Ser Ile Glu Lys Asp Leu Gln Glu Ile Met
        195                 200                 205             
Asp Ser Leu Val Leu Glu Glu Pro Gly Ala Ala Gly Lys Lys Pro Ala
    210                 215                 220                 
Ala Thr Ser Pro Leu Ser Pro Met Ala Asn Gly Gly Arg Tyr Leu Leu
225                 230                 235                 240 
Ser Pro Pro Thr Ser Pro Gly Ala Met Ser Val Gly Ser Ser Tyr Glu
                245                 250                 255     
Asn Thr Ser Pro Ala Phe Ser Pro Leu Ser Ser Pro Ala Ser Ser Gly
            260                 265                 270         
Ser Cys Ala Ser His Ser Pro Ser Gly Gln Glu Pro Gly Pro Ser Val
        275                 280                 285             
Pro Pro Leu Val Pro Ala Arg Ser Ser Ser Tyr His Leu Ala Leu Gln
    290                 295                 300                 
Pro Pro Gln Ser Arg Pro Ser Gly Ala Arg Ser Glu Ser Pro Arg Leu
305                 310                 315                 320 
Ser Arg Lys Gly Gly His Glu Arg Pro Pro Ser Pro Gly Leu Arg Gly
                325                 330                 335     
Leu Leu Thr Asp Ser Pro Ala Ala Thr Val Leu Ala Glu Ala Arg Arg
            340                 345                 350         
Ala Thr Glu Ser Pro Arg Leu Gly Gly Gln Leu Pro Val Val Ala Ile
        355                 360                 365             
Ser Leu Ser Glu Tyr Pro Ala Ser Gly Ala Leu Ser Gln Pro Thr Ser
    370                 375                 380                 
Ile Pro Gly Ser Pro Lys Phe Gln Pro Pro Val Pro Ala Pro Arg Asn
385                 390                 395                 400 
Lys Ile Gly Thr Leu Gln Asp Arg Pro Pro Ser Pro Phe Arg Glu Pro
                405                 410                 415     
Pro Gly Ser Glu Arg Val Leu Thr Thr Ser Pro Ser Arg Gln Leu Val
            420                 425                 430         
Gly Arg Thr Phe Ser Asp Gly Leu Ala Thr Arg Thr Leu Gln Pro Pro
        435                 440                 445             
Glu Ser Pro Arg Leu Gly Arg Arg Gly Leu Asp Ser Met Arg Glu Leu
    450                 455                 460                 
Pro Pro Leu Ser Pro Ser Leu Ser Arg Arg Ala Leu Ser Pro Leu Pro
465                 470                 475                 480 
Thr Arg Thr Thr Pro Asp Pro Lys Leu Asn Arg Glu Val Ala Glu Ser
                485                 490                 495     
Pro Arg Pro Arg Arg Trp Ala Ala His Gly Ala Ser Pro Glu Asp Phe
            500                 505                 510         
Ser Leu Thr Leu Gly Ala Arg Gly Arg Arg Thr Arg Ser Pro Ser Pro
        515                 520                 525             
Thr Leu Gly Glu Ser Leu Ala Pro His Lys Gly Ser Phe Ser Gly Arg
    530                 535                 540                 
Leu Ser Pro Ala Tyr Ser Leu Gly Ser Leu Thr Gly Ala Ser Pro Cys
545                 550                 555                 560 
Gln Ser Pro Cys Val Gln Arg Lys Leu Ser Ser Gly Asp Leu Arg Val
                565                 570                 575     
Pro Val Thr Arg Glu Arg Lys Asn Ser Ile Thr Glu Ile Ser Asp Asn
            580                 585                 590         
Glu Asp Asp Leu Leu Glu Tyr His Arg Arg Gln Arg Gln Glu Arg Leu
        595                 600                 605             
Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln Arg Leu Glu Thr Ile
    610                 615                 620                 
Leu Asn Leu Cys Ala Glu Tyr Ser Arg Ala Asp Gly Gly Pro Glu Ala
625                 630                 635                 640 
Gly Glu Leu Pro Ser Ile Gly Glu Ala Thr Ala Ala Leu Ala Leu Ala
                645                 650                 655     
Gly Arg Arg Pro Ser Arg Gly Leu Ala Gly Ala Ser Gly Arg Ser Ser
            660                 665                 670         
Glu Glu Pro Gly Val Ala Thr Gln Arg Leu Trp Glu Ser Met Glu Arg
        675                 680                 685             
Ser Asp Glu Glu Asn Leu Lys Glu Glu Cys Ser Ser Thr Glu Ser Thr
    690                 695                 700                 
Gln Gln Glu His Glu Asp Ala Pro Ser Thr Lys Leu Gln Gly Glu Val
705                 710                 715                 720 
Leu Ala Leu Glu Glu Glu Arg Ala Gln Val Leu Gly His Val Glu Gln
                725                 730                 735     
Leu Lys Val Arg Val Lys Glu Leu Glu Gln Gln Leu Gln Glu Ser Ala
            740                 745                 750         
Arg Glu Ala Glu Met Glu Arg Ala Leu Leu Gln Gly Glu Arg Glu Ala
        755                 760                 765             
Glu Arg Ala Leu Leu Gln Lys Glu Gln Lys Ala Val Asp Gln Leu Gln
    770                 775                 780                 
Glu Lys Leu Val Ala Leu Glu Thr Gly Ile Gln Lys Glu Arg Asp Lys
785                 790                 795                 800 
Glu Ala Glu Ala Leu Glu Thr Glu Thr Lys Leu Phe Glu Asp Leu Glu
                805                 810                 815     
Phe Gln Gln Leu Glu Arg Glu Ser Arg Val Glu Glu Glu Arg Glu Leu
            820                 825                 830         
Ala Gly Gln Gly Leu Leu Arg Ser Lys Ala Glu Leu Leu Arg Ser Ile
        835                 840                 845             
Ala Lys Arg Lys Glu Arg Leu Ala Ile Leu Asp Ser Gln Ala Gly Gln
    850                 855                 860                 
Ile Arg Ala Gln Ala Val Gln Glu Ser Glu Arg Leu Ala Arg Asp Lys
865                 870                 875                 880 
Asn Ala Ser Leu Gln Leu Leu Gln Lys Glu Lys Glu Lys Leu Thr Val
                885                 890                 895     
Leu Glu Arg Arg Tyr His Ser Leu Thr Gly Gly Arg Pro Phe Pro Lys
            900                 905                 910         
Thr Thr Ser Thr Leu Lys Glu Val Tyr Arg Ser Lys Met Asp Gly Glu
        915                 920                 925             
Ala Thr Ser Pro Leu Pro Arg Thr Arg Ser Gly Pro Leu Pro Ser Ser
    930                 935                 940                 
Ser Gly Ser Ser Ser Ser Ser Ser Gln Leu Ser Val Ala Thr Leu Gly
945                 950                 955                 960 
Arg Ser Pro Ser Pro Lys Ser Ala Leu Leu Thr Gln Asn Gly Thr Gly
                965                 970                 975     
Ser Leu Pro Arg Asn Leu Ala Ala Thr Leu Gln Asp Ile Glu Thr Lys
            980                 985                 990         
Arg Gln Leu Ala Leu Gln Gln Lys Gly Gln Gln Val Ile Glu Glu Gln
        995                 1000                1005            
Arg Arg Arg Leu Ala Glu Leu Lys Gln Lys Ala Ala Ala Glu Ala Gln
    1010                1015                1020                
Cys Gln Trp Asp Ala Leu His Gly Ala Ala Pro Phe Pro Ala Gly Pro
1025                1030                1035                1040
Ser Gly Phe Pro Pro Leu Met His His Ser Ile Leu His His Leu Pro
                1045                1050                1055    
Ala Gly Arg Glu Arg Gly Glu Glu Gly Glu His Ala Tyr Asp Thr Leu
            1060                1065                1070        
Ser Leu Glu Ser Ser Asp Ser Met Glu Thr Ser Ile Ser Thr Gly Gly
        1075                1080                1085            
Asn Ser Ala Cys Ser Pro Asp Asn Met Ser Ser Ala Ser Gly Leu Asp
    1090                1095                1100                
Met Gly Lys Ile Glu Glu Met Glu Lys Met Leu Lys Glu Ala His Ala
1105                1110                1115                1120
Glu Lys Asn Arg Leu Met Glu Ser Arg Glu Arg Glu Met Glu Leu Arg
                1125                1130                1135    
Arg Gln Ala Leu Glu Glu Glu Arg Arg Arg Arg Glu Gln Val Glu Arg
            1140                1145                1150        
Arg Leu Gln Ser Glu Ser Ala Arg Arg Gln Gln Leu Val Glu Lys Glu
        1155                1160                1165            
Val Lys Met Arg Glu Lys Gln Phe Ser Gln Ala Arg Pro Leu Thr Arg
    1170                1175                1180                
Tyr Leu Pro Ile Arg Lys Glu Asp Phe Asp Leu Lys Thr His Ile Glu
1185                1190                1195                1200
Ser Ser Gly His Gly Val Asp Thr Cys Leu His Val Val Leu Ser Ser
                1205                1210                1215    
Lys Val Cys Arg Gly Tyr Leu Val Lys Met Gly Gly Lys Ile Lys Ser
            1220                1225                1230        
Trp Lys Lys Arg Trp Phe Val Phe Asp Arg Leu Lys Arg Thr Leu Ser
        1235                1240                1245            
Tyr Tyr Val Asp Lys His Glu Thr Lys Leu Lys Gly Val Ile Tyr Phe
    1250                1255                1260                
Gln Ala Ile Glu Glu Val Tyr Tyr Asp His Leu Arg Ser Ala Ala Lys
1265                1270                1275                1280
Ser Pro Asn Pro Ala Leu Thr Phe Cys Val Lys Thr His Asp Arg Leu
                1285                1290                1295    
Tyr Tyr Met Val Ala Pro Ser Ala Glu Ala Met Arg Ile Trp Met Asp
            1300                1305                1310        
Val Ile Val Thr Gly Ala Glu Gly Tyr Thr Gln Phe Met Asn
        1315                1320                1325    


<210> 7855
<211> 613
<212> PRT
<213> Homo sapiens

<400> 7855
Met Glu Arg Ala Leu Leu Gln Gly Glu Arg Glu Ala Glu Arg Ala Leu
 1               5                  10                  15      
Leu Gln Lys Glu Gln Lys Ala Val Asp Gln Leu Gln Glu Lys Leu Val
            20                  25                  30          
Ala Leu Glu Thr Gly Ile Gln Lys Glu Arg Asp Lys Glu Arg Ala Glu
        35                  40                  45              
Leu Ala Ala Gly Arg Arg His Leu Glu Ala Arg Gln Ala Leu Tyr Ala
    50                  55                  60                  
Glu Leu Gln Thr Gln Leu Asp Asn Cys Pro Glu Ser Val Arg Glu Gln
65                  70                  75                  80  
Leu Gln Glu Gln Leu Arg Arg Glu Ala Glu Ala Leu Glu Thr Glu Thr
                85                  90                  95      
Lys Leu Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu Arg Glu Ser Arg
            100                 105                 110         
Val Glu Glu Glu Arg Glu Leu Ala Gly Gln Gly Leu Leu Arg Ser Lys
        115                 120                 125             
Ala Glu Leu Leu Arg Ser Ile Ala Lys Arg Lys Glu Arg Leu Ala Ile
    130                 135                 140                 
Leu Asp Ser Gln Ala Gly Gln Ile Arg Ala Gln Ala Val Gln Glu Ser
145                 150                 155                 160 
Glu Arg Leu Ala Arg Asp Lys Asn Ala Ser Leu Gln Leu Leu Gln Lys
                165                 170                 175     
Glu Lys Glu Lys Leu Thr Val Leu Glu Arg Arg Tyr His Ser Leu Thr
            180                 185                 190         
Gly Gly Arg Pro Phe Pro Lys Thr Thr Ser Thr Leu Lys Glu Val Tyr
        195                 200                 205             
Arg Ser Lys Met Asp Gly Glu Ala Thr Ser Pro Leu Pro Arg Thr Arg
    210                 215                 220                 
Ser Gly Pro Leu Pro Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gln
225                 230                 235                 240 
Leu Ser Val Ala Thr Leu Gly Arg Ser Pro Ser Pro Lys Ser Ala Leu
                245                 250                 255     
Leu Thr Gln Asn Gly Thr Gly Ser Leu Pro Arg Asn Leu Ala Ala Thr
            260                 265                 270         
Leu Gln Asp Ile Glu Thr Lys Arg Gln Leu Ala Leu Gln Gln Lys Gly
        275                 280                 285             
Gln Gln Val Ile Glu Glu Gln Arg Arg Arg Leu Ala Glu Leu Lys Gln
    290                 295                 300                 
Lys Ala Ala Ala Glu Ala Gln Cys Gln Trp Asp Ala Leu His Gly Ala
305                 310                 315                 320 
Ala Pro Phe Pro Ala Gly Pro Ser Gly Phe Pro Pro Leu Met His His
                325                 330                 335     
Ser Ile Leu His His Leu Pro Ala Gly Arg Glu Arg Gly Glu Glu Gly
            340                 345                 350         
Glu His Ala Tyr Asp Thr Leu Ser Leu Glu Ser Ser Asp Ser Met Glu
        355                 360                 365             
Thr Ser Ile Ser Thr Gly Gly Asn Ser Ala Cys Ser Pro Asp Asn Met
    370                 375                 380                 
Ser Ser Ala Ser Gly Leu Asp Met Gly Lys Ile Glu Glu Met Glu Lys
385                 390                 395                 400 
Met Leu Lys Glu Ala His Ala Glu Lys Asn Arg Leu Met Glu Ser Arg
                405                 410                 415     
Glu Arg Glu Met Glu Leu Arg Arg Gln Ala Leu Glu Glu Glu Arg Arg
            420                 425                 430         
Arg Arg Glu Gln Val Glu Arg Arg Leu Gln Ser Glu Ser Ala Arg Arg
        435                 440                 445             
Gln Gln Leu Val Glu Lys Glu Val Lys Met Arg Glu Lys Gln Phe Ser
    450                 455                 460                 
Gln Ala Arg Pro Leu Thr Arg Tyr Leu Pro Ile Arg Lys Glu Asp Phe
465                 470                 475                 480 
Asp Leu Lys Thr His Ile Glu Ser Ser Gly His Gly Val Asp Thr Cys
                485                 490                 495     
Leu His Val Val Leu Ser Ser Lys Val Cys Arg Gly Tyr Leu Val Lys
            500                 505                 510         
Met Gly Gly Lys Ile Lys Ser Trp Lys Lys Arg Trp Phe Val Phe Asp
        515                 520                 525             
Arg Leu Lys Arg Thr Leu Ser Tyr Tyr Val Asp Lys His Glu Thr Lys
    530                 535                 540                 
Leu Lys Gly Val Ile Tyr Phe Gln Ala Ile Glu Glu Val Tyr Tyr Asp
545                 550                 555                 560 
His Leu Arg Ser Ala Ala Lys Ser Pro Asn Pro Ala Leu Thr Phe Cys
                565                 570                 575     
Val Lys Thr His Asp Arg Leu Tyr Tyr Met Val Ala Pro Ser Ala Glu
            580                 585                 590         
Ala Met Arg Ile Trp Met Asp Val Ile Val Thr Gly Ala Glu Gly Tyr
        595                 600                 605             
Thr Gln Phe Met Asn
    610             


<210> 7856
<211> 844
<212> PRT
<213> Homo sapiens

<400> 7856
Met Val Thr Val Met Pro Leu Glu Met Glu Lys Thr Ile Ser Lys Leu
 1               5                  10                  15      
Met Phe Asp Phe Gln Arg Asn Ser Thr Ser Asp Asp Asp Ser Gly Cys
            20                  25                  30          
Ala Leu Glu Glu Tyr Ala Trp Val Pro Pro Gly Leu Lys Pro Glu Gln
        35                  40                  45              
Val His Gln Tyr Tyr Ser Cys Leu Pro Glu Glu Lys Val Pro Tyr Val
    50                  55                  60                  
Asn Ser Pro Gly Glu Lys Leu Arg Ile Lys Gln Leu Leu His Gln Leu
65                  70                  75                  80  
Pro Pro His Asp Asn Glu Val Arg Tyr Cys Asn Ser Leu Asp Glu Glu
                85                  90                  95      
Glu Lys Arg Glu Leu Lys Leu Phe Ser Ser Gln Arg Lys Arg Glu Asn
            100                 105                 110         
Leu Gly Arg Gly Asn Val Arg Pro Phe Pro Val Thr Met Thr Gly Ala
        115                 120                 125             
Ile Cys Glu Gln Cys Gly Gly Gln Ile Asn Gly Gly Asp Ile Ala Val
    130                 135                 140                 
Phe Ala Ser Arg Ala Gly His Gly Val Cys Trp His Pro Pro Cys Phe
145                 150                 155                 160 
Val Cys Thr Val Cys Asn Glu Leu Leu Val Asp Leu Ile Tyr Phe Tyr
                165                 170                 175     
Gln Asp Gly Lys Ile Tyr Cys Gly Arg His His Ala Glu Cys Leu Lys
            180                 185                 190         
Pro Arg Cys Ala Ala Cys Asp Glu Ile Ile Phe Ala Asp Glu Cys Thr
        195                 200                 205             
Glu Ala Glu Gly Arg His Trp His Met Lys His Phe Cys Cys Phe Glu
    210                 215                 220                 
Cys Glu Thr Val Leu Gly Gly Gln Arg Tyr Ile Met Lys Glu Gly Arg
225                 230                 235                 240 
Pro Tyr Cys Cys His Cys Phe Glu Ser Leu Tyr Ala Glu Tyr Cys Asp
                245                 250                 255     
Thr Cys Ala Gln His Ile Gly Ile Asp Gln Gly Gln Met Thr Tyr Asp
            260                 265                 270         
Gly Gln His Trp His Ala Thr Glu Thr Cys Phe Cys Cys Ala His Cys
        275                 280                 285             
Lys Lys Ser Leu Leu Gly Arg Pro Phe Leu Pro Lys Gln Gly Gln Ile
    290                 295                 300                 
Phe Cys Ser Arg Ala Cys Ser Ala Gly Glu Asp Pro Asn Gly Ser Asp
305                 310                 315                 320 
Ser Ser Asp Ser Ala Phe Gln Asn Ala Arg Ala Lys Glu Ser Arg Arg
                325                 330                 335     
Ser Ala Lys Ile Gly Lys Asn Lys Gly Lys Thr Glu Glu Pro Met Leu
            340                 345                 350         
Asn Gln His Ser Gln Leu Gln Val Ser Ser Asn Arg Leu Ser Ala Asp
        355                 360                 365             
Val Asp Pro Leu Ser Leu Gln Met Asp Met Leu Ser Leu Ser Ser Gln
    370                 375                 380                 
Thr Pro Ser Leu Asn Arg Asp Pro Ile Trp Arg Ser Arg Glu Glu Pro
385                 390                 395                 400 
Tyr His Tyr Gly Asn Lys Met Glu Gln Asn Gln Thr Gln Ser Pro Leu
                405                 410                 415     
Gln Leu Leu Ser Gln Cys Asn Ile Arg Thr Ser Tyr Ser Pro Gly Gly
            420                 425                 430         
Gln Gly Ala Gly Ala Gln Pro Glu Met Trp Gly Lys His Phe Ser Asn
        435                 440                 445             
Pro Lys Arg Ser Ser Ser Leu Ala Met Thr Gly His Ala Gly Ser Phe
    450                 455                 460                 
Ile Lys Glu Cys Arg Glu Asp Tyr Tyr Pro Gly Arg Leu Arg Ser Gln
465                 470                 475                 480 
Glu Ser Tyr Ser Asp Met Ser Ser Gln Ser Phe Ser Glu Thr Arg Gly
                485                 490                 495     
Ser Ile Gln Val Pro Lys Tyr Glu Glu Glu Glu Glu Glu Glu Gly Gly
            500                 505                 510         
Leu Ser Thr Gln Gln Cys Arg Thr Arg His Pro Ile Ser Ser Leu Lys
        515                 520                 525             
Tyr Thr Glu Asp Met Thr Pro Thr Glu Gln Thr Pro Arg Gly Ser Met
    530                 535                 540                 
Glu Ser Leu Ala Leu Ser Asn Ala Thr Gly Leu Ser Ala Asp Gly Gly
545                 550                 555                 560 
Ala Lys Arg Gln Glu His Leu Ser Arg Phe Ser Met Pro Asp Leu Ser
                565                 570                 575     
Lys Asp Ser Gly Met Asn Val Ser Glu Lys Leu Ser Asn Met Gly Thr
            580                 585                 590         
Leu Asn Ser Ser Met Gln Phe Arg Ser Ala Glu Ser Val Arg Ser Leu
        595                 600                 605             
Leu Ser Ala Gln Gln Tyr Gln Glu Met Glu Gly Asn Leu His Gln Leu
    610                 615                 620                 
Ser Asn Pro Ile Gly Tyr Arg Asp Leu Gln Ser His Gly Arg Met His
625                 630                 635                 640 
Gln Ser Phe Asp Phe Asp Gly Gly Met Ala Gly Ser Lys Leu Pro Gly
                645                 650                 655     
Gln Glu Gly Val Arg Ile Gln Pro Met Ser Glu Arg Thr Arg Arg Arg
            660                 665                 670         
Ala Thr Ser Arg Asp Asp Asn Arg Arg Phe Arg Pro His Arg Ser Arg
        675                 680                 685             
Arg Ser Arg Arg Ser Arg Ser Asp Asn Ala Leu His Leu Ala Ser Glu
    690                 695                 700                 
Arg Glu Ala Ile Ser Arg Leu Lys Asp Arg Pro Pro Leu Arg Ala Arg
705                 710                 715                 720 
Glu Asp Tyr Asp Gln Phe Met Arg Gln Arg Ser Phe Gln Glu Ser Met
                725                 730                 735     
Gly His Gly Ser Arg Arg Asp Leu Tyr Gly Gln Cys Pro Arg Thr Val
            740                 745                 750         
Ser Asp Leu Ala Leu Gln Asn Ala Phe Gly Asp Arg Trp Gly Pro Tyr
        755                 760                 765             
Phe Ala Glu Tyr Asp Trp Cys Ser Thr Cys Ser Ser Ser Ser Glu Ser
    770                 775                 780                 
Asp Asn Glu Gly Tyr Phe Leu Gly Glu Pro Ile Pro Gln Pro Ala Arg
785                 790                 795                 800 
Leu Arg Tyr Val Thr Ser Asp Glu Leu Leu His Lys Tyr Ser Ser Tyr
                805                 810                 815     
Gly Leu Pro Lys Ser Ser Thr Leu Gly Gly Arg Gly Gln Leu His Ser
            820                 825                 830         
Arg Lys Arg Gln Lys Ser Lys Asn Cys Ile Ile Ser
        835                 840                 


<210> 7857
<211> 529
<212> PRT
<213> Homo sapiens

<400> 7857
Met Glu Gln Glu Lys Lys Leu Leu Val Ser Asp Ser Asn Ser Phe Met
 1               5                  10                  15      
Glu Arg Glu Ser Leu Lys Ser Pro Phe Thr Gly Asp Thr Ser Met Asn
            20                  25                  30          
Asn Leu Glu Thr Val His His Asn Asn Ser Lys Ala Asp Lys Leu Lys
        35                  40                  45              
Glu Lys Pro Ser Glu Trp Ser Lys Arg His Arg Pro Gln His Tyr Lys
    50                  55                  60                  
His Glu Asp Ala Lys Glu Met Pro Leu Thr Trp Val Gln Asp Glu Ile
65                  70                  75                  80  
Trp Cys His Asp Ser Tyr Glu Ser Asp Gly Lys Ser Glu Asn Trp Gly
                85                  90                  95      
Asn Phe Ile Ala Lys Glu Glu Glu Lys Pro Asn His Gln Glu Trp Asp
            100                 105                 110         
Ser Gly Glu His Thr Asn Ala Cys Val Gln Gln Asn Ser Ser Phe Val
        115                 120                 125             
Asp Arg Pro Tyr Lys Cys Ser Glu Cys Trp Lys Ser Phe Ser Asn Ser
    130                 135                 140                 
Ser His Leu Arg Thr His Gln Arg Thr His Ser Gly Glu Lys Pro Tyr
145                 150                 155                 160 
Lys Cys Ser Glu Cys Ala Lys Cys Phe Cys Asn Ser Ser His Leu Ile
                165                 170                 175     
Gln His Leu Arg Met His Thr Gly Glu Lys Pro Tyr Gln Cys Gly Glu
            180                 185                 190         
Cys Gly Lys Ser Phe Ser Asn Thr Ser His Leu Ile Ile His Glu Arg
        195                 200                 205             
Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Arg
    210                 215                 220                 
Phe Ser Ser Ser Ser His Leu Ile Gln His His Arg Ser His Thr Gly
225                 230                 235                 240 
Glu Lys Pro Tyr Glu Cys Ser Val Cys Gly Lys Gly Phe Ser His Ser
                245                 250                 255     
Tyr Val Leu Ile Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr
            260                 265                 270         
Lys Cys Pro Asp Cys Gly Lys Ser Phe Ser Gln Ser Ser Ser Leu Ile
        275                 280                 285             
Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Leu Glu
    290                 295                 300                 
Cys Glu Lys Ser Phe Gly Cys Asn Ser Thr Leu Ile Lys His Gln Arg
305                 310                 315                 320 
Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Pro Glu Cys Gly Lys Asn
                325                 330                 335     
Phe Ser Arg Ser Ser Asn Leu Ile Thr His Gln Lys Met His Thr Gly
            340                 345                 350         
Glu Lys Ser Tyr Glu Ser Ser Glu Tyr Glu Glu Ser Leu Gly Gln Asn
        355                 360                 365             
Cys Asn Val Ile Glu Glu Cys Arg Ile Gln Leu Gly Glu Lys Pro Tyr
    370                 375                 380                 
Arg Cys Cys Glu Cys Gly Lys Ser Phe Gly Leu Ser Ser His Leu Ile
385                 390                 395                 400 
Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Arg Cys Ser Glu
                405                 410                 415     
Cys Trp Lys Thr Phe Ser Gln Ser Ser Thr Leu Val Ile His Gln Arg
            420                 425                 430         
Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Asp Cys Gly Glu Ser
        435                 440                 445             
Phe Ser Gln Ser Phe Asn Leu Ile Arg His Arg Arg Thr His Ile Gly
    450                 455                 460                 
Glu Lys Pro Tyr Lys Cys Thr Ser Cys Glu Lys Cys Phe Ser Arg Ile
465                 470                 475                 480 
Ala Tyr Leu Ser Gln His Arg Lys Ile His Val Glu Lys Pro Phe Glu
                485                 490                 495     
Ser Pro Asp Val Gly Asp Phe Pro His Glu Trp Thr Trp Lys Asn Cys
            500                 505                 510         
Ser Gly Glu Met Pro Phe Ile Ser Ser Phe Ser Val Ser Asn Ser Ser
        515                 520                 525             
Ser
    


<210> 7858
<211> 824
<212> PRT
<213> Homo sapiens

<400> 7858
Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu
 1               5                  10                  15      
Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala
            20                  25                  30          
Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly
        35                  40                  45              
Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly
    50                  55                  60                  
Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala
65                  70                  75                  80  
Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile
                85                  90                  95      
Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala
            100                 105                 110         
Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser
        115                 120                 125             
Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu
    130                 135                 140                 
Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu
145                 150                 155                 160 
Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln
                165                 170                 175     
Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser
            180                 185                 190         
Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln
        195                 200                 205             
Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg
    210                 215                 220                 
Pro Gly Ala Pro Ala Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp
225                 230                 235                 240 
Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr
                245                 250                 255     
Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln
            260                 265                 270         
Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys
        275                 280                 285             
Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg
    290                 295                 300                 
Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala
305                 310                 315                 320 
Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu
                325                 330                 335     
Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp
            340                 345                 350         
Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly
        355                 360                 365             
Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly
    370                 375                 380                 
Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp
385                 390                 395                 400 
Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val
                405                 410                 415     
Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys
            420                 425                 430         
Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu
        435                 440                 445             
Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro
    450                 455                 460                 
Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu
465                 470                 475                 480 
Glu Asp Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys
                485                 490                 495     
Glu Val Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp
            500                 505                 510         
Val Thr Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly
        515                 520                 525             
Thr Asn Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln
    530                 535                 540                 
Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln
545                 550                 555                 560 
Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe
                565                 570                 575     
Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met
            580                 585                 590         
Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys
        595                 600                 605             
Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly
    610                 615                 620                 
Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr
625                 630                 635                 640 
Leu Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu
                645                 650                 655     
Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser
            660                 665                 670         
Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys
        675                 680                 685             
Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly
    690                 695                 700                 
His Arg Gly Arg Gly Gly Leu Asn Met Arg Gly Gly Asn Phe Arg Gly
705                 710                 715                 720 
Gly Ala Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met Pro
                725                 730                 735     
Gln Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro Tyr
            740                 745                 750         
Pro Arg Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg Gly
        755                 760                 765             
Asn Tyr Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln Asn
    770                 775                 780                 
Phe Arg Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln Gly
785                 790                 795                 800 
Tyr Asn Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp Ser
                805                 810                 815     
Gln His Tyr His Gln Gly Tyr Tyr
            820                 


<210> 7859
<211> 813
<212> PRT
<213> Homo sapiens

<400> 7859
Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu
 1               5                  10                  15      
Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala
            20                  25                  30          
Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly
        35                  40                  45              
Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly
    50                  55                  60                  
Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala
65                  70                  75                  80  
Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile
                85                  90                  95      
Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala
            100                 105                 110         
Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser
        115                 120                 125             
Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu
    130                 135                 140                 
Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu
145                 150                 155                 160 
Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln
                165                 170                 175     
Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser
            180                 185                 190         
Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln
        195                 200                 205             
Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys
    210                 215                 220                 
Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu
225                 230                 235                 240 
Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro
                245                 250                 255     
Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp
            260                 265                 270         
Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser
        275                 280                 285             
Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly
    290                 295                 300                 
Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys
305                 310                 315                 320 
Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp
                325                 330                 335     
Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu
            340                 345                 350         
Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys
        355                 360                 365             
Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn
    370                 375                 380                 
Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu
385                 390                 395                 400 
Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser
                405                 410                 415     
Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His
            420                 425                 430         
Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe
        435                 440                 445             
Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp
    450                 455                 460                 
Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val
465                 470                 475                 480 
Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr
                485                 490                 495     
Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn
            500                 505                 510         
Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala
        515                 520                 525             
Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu
    530                 535                 540                 
Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu
545                 550                 555                 560 
Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu
                565                 570                 575     
Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu
            580                 585                 590         
Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp
        595                 600                 605             
Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Arg Asn Phe Thr Leu
    610                 615                 620                 
Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln
625                 630                 635                 640 
Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys
                645                 650                 655     
Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser
            660                 665                 670         
Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His
        675                 680                 685             
Arg Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly
    690                 695                 700                 
Gly Asn Ser Cys Leu Leu Ala Pro Gly Asn Arg Gly Gly Tyr Asn Arg
705                 710                 715                 720 
Arg Gly Asn Met Pro Gln Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly
                725                 730                 735     
Ile Gly Tyr Pro Tyr Pro Arg Ala Pro Val Phe Pro Gly Arg Gly Ser
            740                 745                 750         
Tyr Ser Asn Arg Gly Asn Tyr Asn Arg Gly Gly Met Pro Asn Arg Gly
        755                 760                 765             
Asn Tyr Asn Gln Asn Phe Arg Gly Arg Gly Asn Asn Arg Gly Tyr Lys
    770                 775                 780                 
Asn Gln Ser Gln Gly Tyr Asn Gln Trp Gln Gln Gly Gln Phe Trp Gly
785                 790                 795                 800 
Gln Lys Pro Trp Ser Gln His Tyr His Gln Gly Tyr Tyr
                805                 810             


<210> 7860
<211> 229
<212> PRT
<213> Homo sapiens

<400> 7860
Met Thr Thr Ala Ala Arg Pro Thr Phe Glu Pro Ala Arg Gly Gly Arg
 1               5                  10                  15      
Gly Lys Gly Glu Gly Asp Leu Ser Gln Leu Ser Lys Gln Tyr Ser Ser
            20                  25                  30          
Arg Asp Leu Pro Ser His Thr Lys Ile Lys Tyr Arg Gln Thr Thr Gln
        35                  40                  45              
Asp Ala Pro Glu Glu Val Arg Asn Arg Asp Phe Arg Arg Glu Leu Glu
    50                  55                  60                  
Glu Arg Glu Arg Ala Ala Ala Arg Glu Lys Asn Arg Asp Arg Pro Thr
65                  70                  75                  80  
Arg Glu His Thr Thr Ser Ser Ser Val Ser Lys Lys Pro Arg Leu Asp
                85                  90                  95      
Gln Ile Pro Ala Ala Asn Leu Asp Ala Asp Asp Pro Leu Thr Asp Glu
            100                 105                 110         
Glu Asp Glu Asp Phe Glu Glu Glu Ser Asp Asp Asp Asp Thr Ala Ala
        115                 120                 125             
Leu Leu Ala Glu Leu Glu Lys Ile Lys Lys Glu Arg Ala Glu Glu Gln
    130                 135                 140                 
Ala Arg Lys Asp Gln Glu Gln Lys Ala Glu Glu Glu Arg Ile Arg Met
145                 150                 155                 160 
Glu Asn Ile Leu Ser Gly Asn Pro Leu Leu Asn Leu Thr Gly Pro Ser
                165                 170                 175     
Gln Pro Gln Ala Asn Phe Lys Val Lys Arg Arg Trp Asp Asp Asp Val
            180                 185                 190         
Val Phe Lys Asn Cys Ala Lys Gly Val Asp Asp Gln Lys Lys Asp Lys
        195                 200                 205             
Arg Phe Val Asn Asp Thr Leu Arg Ser Glu Phe His Lys Lys Phe Met
    210                 215                 220                 
Glu Lys Tyr Ile Lys
225                 


<210> 7861
<211> 395
<212> PRT
<213> Homo sapiens

<400> 7861
Met Met Ala Ala Lys Val Val Pro Met Pro Pro Lys Pro Lys Gln Ser
 1               5                  10                  15      
Phe Ile Leu Arg Val Pro Pro Asp Ser Lys Leu Gly Gln Asp Leu Leu
            20                  25                  30          
Arg Asp Ala Thr Asn Gly Pro Lys Thr Ile His Gln Leu Val Leu Glu
        35                  40                  45              
His Phe Leu Thr Phe Leu Pro Lys Pro Ser Leu Val Gln Pro Ser Gln
    50                  55                  60                  
Lys Val Lys Glu Thr Leu Val Ile Met Lys Asp Val Ser Ser Ser Leu
65                  70                  75                  80  
Gln Asn Arg Val His Pro Arg Pro Leu Val Lys Leu Leu Pro Lys Gly
                85                  90                  95      
Val Gln Lys Glu Gln Glu Thr Val Ser Leu Tyr Leu Lys Ala Asn Pro
            100                 105                 110         
Glu Glu Leu Val Val Phe Glu Asp Leu Asn Val Phe His Cys Gln Glu
        115                 120                 125             
Glu Cys Val Ser Leu Asp Pro Thr Gln Gln Leu Thr Ser Glu Lys Glu
    130                 135                 140                 
Asp Asp Ser Ser Val Gly Glu Met Met Leu Leu Ala Val Asn Gly Ser
145                 150                 155                 160 
Asn Pro Glu Gly Glu Asp Pro Glu Arg Glu Pro Val Glu Asn Glu Asp
                165                 170                 175     
Tyr Arg Glu Lys Ser Ser Asp Asp Asp Glu Met Asp Ser Ser Leu Val
            180                 185                 190         
Ser Gln Gln Pro Pro Asp Asn Gln Glu Lys Glu Arg Leu Asn Thr Ser
        195                 200                 205             
Ile Pro Gln Lys Arg Lys Met Arg Asn Leu Leu Val Thr Ile Glu Asn
    210                 215                 220                 
Asp Thr Pro Leu Glu Glu Leu Ser Lys Tyr Val Asp Ile Ser Ile Ile
225                 230                 235                 240 
Ala Leu Thr Arg Asn Arg Arg Thr Arg Arg Trp Tyr Thr Cys Pro Leu
                245                 250                 255     
Cys Gly Lys Gln Phe Asn Glu Ser Ser Tyr Leu Ile Ser His Gln Arg
            260                 265                 270         
Thr His Thr Gly Glu Lys Pro Tyr Asp Cys Asn His Cys Gly Lys Ser
        275                 280                 285             
Phe Asn His Lys Thr Asn Leu Asn Lys His Glu Arg Ile His Thr Gly
    290                 295                 300                 
Glu Lys Pro Tyr Ser Cys Ser Gln Cys Gly Lys Asn Phe Arg Gln Asn
305                 310                 315                 320 
Ser His Arg Ser Arg His Glu Gly Ile His Ile Arg Glu Lys Ile Phe
                325                 330                 335     
Lys Cys Pro Glu Cys Gly Lys Thr Phe Pro Lys Asn Glu Glu Phe Val
            340                 345                 350         
Leu His Leu Gln Ser His Glu Ala Glu Arg Pro Tyr Gly Cys Lys Lys
        355                 360                 365             
Cys Gly Arg Arg Phe Gly Arg Leu Ser Asn Cys Thr Arg His Glu Lys
    370                 375                 380                 
Thr His Ser Ala Cys Lys Thr Arg Lys Gln Lys
385                 390                 395 


<210> 7862
<211> 394
<212> PRT
<213> Homo sapiens

<400> 7862
Met Met Ala Ala Lys Val Val Pro Met Pro Pro Lys Pro Lys Gln Ser
 1               5                  10                  15      
Phe Ile Leu Arg Val Pro Pro Asp Ser Lys Leu Gly Gln Asp Leu Leu
            20                  25                  30          
Arg Asp Ala Thr Asn Gly Pro Lys Thr Ile His Gln Leu Val Leu Glu
        35                  40                  45              
His Phe Leu Thr Phe Leu Pro Lys Pro Ser Leu Val Gln Pro Ser Gln
    50                  55                  60                  
Lys Val Lys Glu Thr Leu Val Ile Met Lys Asp Val Ser Ser Ser Leu
65                  70                  75                  80  
Gln Asn Arg Val His Pro Arg Pro Leu Val Lys Leu Leu Pro Lys Gly
                85                  90                  95      
Val Gln Lys Glu Gln Glu Thr Val Ser Leu Tyr Leu Lys Ala Asn Pro
            100                 105                 110         
Glu Leu Val Val Phe Glu Asp Leu Asn Val Phe His Cys Gln Glu Glu
        115                 120                 125             
Cys Val Ser Leu Asp Pro Thr Gln Gln Leu Thr Ser Glu Lys Glu Asp
    130                 135                 140                 
Asp Ser Ser Val Gly Glu Met Met Leu Leu Ala Val Asn Gly Ser Asn
145                 150                 155                 160 
Pro Glu Gly Glu Asp Pro Glu Arg Glu Pro Val Glu Asn Glu Asp Tyr
                165                 170                 175     
Arg Glu Lys Ser Ser Asp Asp Asp Glu Met Asp Ser Ser Leu Val Ser
            180                 185                 190         
Gln Gln Pro Pro Asp Asn Gln Glu Lys Glu Arg Leu Asn Thr Ser Ile
        195                 200                 205             
Pro Gln Lys Arg Lys Met Arg Asn Leu Leu Val Thr Ile Glu Asn Asp
    210                 215                 220                 
Thr Pro Leu Glu Glu Leu Ser Lys Tyr Val Asp Ile Ser Ile Ile Ala
225                 230                 235                 240 
Leu Thr Arg Asn Arg Arg Thr Arg Arg Trp Tyr Thr Cys Pro Leu Cys
                245                 250                 255     
Gly Lys Gln Phe Asn Glu Ser Ser Tyr Leu Ile Ser His Gln Arg Thr
            260                 265                 270         
His Thr Gly Glu Lys Pro Tyr Asp Cys Asn His Cys Gly Lys Ser Phe
        275                 280                 285             
Asn His Lys Thr Asn Leu Asn Lys His Glu Arg Ile His Thr Gly Glu
    290                 295                 300                 
Lys Pro Tyr Ser Cys Ser Gln Cys Gly Lys Asn Phe Arg Gln Asn Ser
305                 310                 315                 320 
His Arg Ser Arg His Glu Gly Ile His Ile Arg Glu Lys Ile Phe Lys
                325                 330                 335     
Cys Pro Glu Cys Gly Lys Thr Phe Pro Lys Asn Glu Glu Phe Val Leu
            340                 345                 350         
His Leu Gln Ser His Glu Ala Glu Arg Pro Tyr Gly Cys Lys Lys Cys
        355                 360                 365             
Gly Arg Arg Phe Gly Arg Leu Ser Asn Cys Thr Arg His Glu Lys Thr
    370                 375                 380                 
His Ser Ala Cys Lys Thr Arg Lys Gln Lys
385                 390                 


<210> 7863
<211> 1919
<212> PRT
<213> Homo sapiens

<400> 7863
Gly Cys Val Glu Gly Ala Ala Pro Arg Met Ala Thr Ala Asp Thr Pro
 1               5                  10                  15      
Ala Pro Ala Ser Ser Gly Leu Ser Pro Lys Glu Glu Gly Glu Leu Glu
            20                  25                  30          
Asp Gly Glu Ile Ser Asp Asp Asp Asn Asn Ser Gln Ile Arg Ser Arg
        35                  40                  45              
Ser Ser Ser Ser Ser Ser Gly Gly Gly Leu Leu Pro Tyr Pro Arg Arg
    50                  55                  60                  
Arg Pro Pro His Ser Ala Arg Gly Gly Gly Ser Gly Gly Gly Gly Gly
65                  70                  75                  80  
Ser Ser Ser Ser Ser Ser Ser Ser Gln Gln Gln Leu Arg Asn Phe Ser
                85                  90                  95      
Arg Ser Arg His Ala Ser Glu Arg Gly His Leu Arg Gly Pro Ser Ser
            100                 105                 110         
Tyr Arg Pro Lys Glu Pro Phe Arg Ser His Pro Pro Ser Val Arg Met
        115                 120                 125             
Pro Ser Ser Ser Leu Ser Glu Ser Ser Pro Arg Pro Ser Phe Trp Glu
    130                 135                 140                 
Arg Ser His Leu Ala Leu Asp Arg Phe Arg Phe Arg Gly Arg Pro Tyr
145                 150                 155                 160 
Arg Gly Gly Ser Arg Trp Ser Arg Gly Arg Gly Val Gly Glu Arg Gly
                165                 170                 175     
Gly Lys Pro Gly Cys Arg Pro Pro Leu Gly Gly Gly Ala Gly Ser Gly
            180                 185                 190         
Phe Ser Ser Ser Gln Ser Trp Arg Glu Pro Ser Pro Pro Arg Lys Ser
        195                 200                 205             
Ser Lys Ser Phe Gly Arg Ser Pro Ser Arg Lys Gln Asn Tyr Ser Ser
    210                 215                 220                 
Lys Asn Glu Asn Cys Val Glu Glu Thr Phe Glu Asp Leu Leu Leu Lys
225                 230                 235                 240 
Tyr Lys Gln Ile Gln Leu Glu Leu Glu Cys Ile Asn Lys Asp Glu Lys
                245                 250                 255     
Leu Ala Leu Ser Ser Lys Glu Glu Asn Val Gln Glu Asp Pro Lys Thr
            260                 265                 270         
Leu Asn Phe Glu Asp Gln Thr Ser Thr Asp Asn Val Ser Ile Thr Lys
        275                 280                 285             
Asp Ser Ser Lys Glu Val Ala Pro Glu Glu Lys Thr Gln Val Lys Thr
    290                 295                 300                 
Phe Gln Ala Phe Glu Leu Lys Pro Leu Arg Gln Lys Leu Thr Leu Pro
305                 310                 315                 320 
Gly Asp Lys Asn Arg Leu Lys Lys Val Lys Asp Gly Ala Lys Pro Leu
                325                 330                 335     
Ser Leu Lys Ser Asp Thr Thr Asp Ser Ser Gln Gly Leu Gln Asp Lys
            340                 345                 350         
Glu Gln Asn Leu Thr Arg Arg Ile Ser Thr Ser Asp Ile Leu Ser Glu
        355                 360                 365             
Lys Lys Leu Gly Glu Asp Glu Glu Glu Leu Ser Glu Leu Gln Leu Arg
    370                 375                 380                 
Leu Leu Ala Leu Gln Ser Ala Ser Lys Lys Trp Gln Gln Lys Glu Gln
385                 390                 395                 400 
Gln Val Met Lys Glu Ser Lys Glu Lys Leu Thr Lys Thr Lys Thr Val
                405                 410                 415     
Gln Gln Lys Val Lys Thr Ser Thr Lys Thr His Ser Ala Lys Lys Val
            420                 425                 430         
Ser Thr Thr Ala Lys Gln Ala Leu Arg Lys Gln Gln Thr Lys Ala Trp
        435                 440                 445             
Lys Lys Leu Gln Gln Gln Lys Glu Gln Glu Arg Gln Lys Glu Glu Asp
    450                 455                 460                 
Gln Arg Lys Gln Ala Glu Glu Glu Glu Arg Arg Lys Arg Glu Glu Glu
465                 470                 475                 480 
Ile Arg Lys Ile Arg Asp Leu Ser Asn Gln Glu Glu Gln Tyr Asn Arg
                485                 490                 495     
Phe Met Lys Leu Val Gly Gly Lys Arg Arg Ser Arg Ser Lys Ser Ser
            500                 505                 510         
Asp Pro Asp Leu Arg Arg Ser Leu Asp Lys Gln Pro Thr Asp Ser Gly
        515                 520                 525             
Gly Gly Ile Tyr Gln Tyr Asp Asn Tyr Glu Glu Val Ala Met Asp Thr
    530                 535                 540                 
Asp Ser Glu Thr Ser Ser Pro Ala Pro Ser Pro Val Gln Pro Pro Phe
545                 550                 555                 560 
Phe Ser Glu Cys Ser Leu Gly Tyr Phe Ser Pro Ala Pro Ser Leu Ser
                565                 570                 575     
Leu Pro Pro Pro Pro Gln Val Ser Ser Leu Pro Pro Leu Ser Gln Pro
            580                 585                 590         
Tyr Val Glu Gly Leu Cys Val Ser Leu Glu Pro Leu Pro Pro Leu Pro
        595                 600                 605             
Pro Leu Pro Pro Leu Pro Pro Glu Asp Pro Glu Gln Pro Pro Lys Pro
    610                 615                 620                 
Pro Phe Ala Asp Glu Glu Glu Glu Glu Glu Met Leu Leu Arg Glu Glu
625                 630                 635                 640 
Leu Leu Lys Ser Leu Ala Asn Lys Arg Ala Phe Lys Pro Glu Glu Thr
                645                 650                 655     
Ser Ser Asn Ser Asp Pro Pro Ser Pro Pro Val Leu Asn Asn Ser His
            660                 665                 670         
Pro Val Pro Arg Ser Asn Leu Ser Ile Val Ser Ile Asn Thr Val Ser
        675                 680                 685             
Gln Pro Arg Ile Gln Asn Pro Lys Phe His Arg Gly Pro Arg Leu Pro
    690                 695                 700                 
Arg Thr Val Ile Ser Leu Pro Lys His Lys Ser Val Val Val Thr Leu
705                 710                 715                 720 
Asn Asp Ser Asp Asp Ser Glu Ser Asp Gly Glu Ala Ser Lys Ser Thr
                725                 730                 735     
Asn Ser Val Phe Gly Gly Leu Glu Ser Met Ile Lys Glu Ala Arg Arg
            740                 745                 750         
Thr Ala Glu Gln Ala Ser Lys Pro Lys Val Pro Pro Lys Ser Glu Lys
        755                 760                 765             
Glu Asn Asp Pro Leu Arg Thr Pro Glu Ala Leu Pro Glu Glu Lys Lys
    770                 775                 780                 
Ile Glu Tyr Arg Leu Leu Lys Glu Glu Ile Ala Asn Arg Glu Lys Gln
785                 790                 795                 800 
Arg Leu Ile Lys Ser Asp Gln Leu Lys Thr Ser Ser Ser Ser Pro Ala
                805                 810                 815     
Asn Ser Asp Val Glu Ile Asp Gly Ile Gly Arg Ile Ala Met Val Thr
            820                 825                 830         
Lys Gln Val Thr Asp Ala Glu Ser Lys Leu Lys Lys His Arg Ile Leu
        835                 840                 845             
Leu Met Lys Asp Glu Ser Val Leu Lys Asn Leu Val Gln Gln Glu Ala
    850                 855                 860                 
Lys Lys Lys Glu Ser Val Arg Asn Ala Glu Ala Lys Ile Thr Lys Leu
865                 870                 875                 880 
Thr Glu Gln Leu Gln Ala Thr Glu Lys Ile Leu Asn Val Asn Arg Met
                885                 890                 895     
Phe Leu Lys Lys Leu Gln Glu Gln Ile His Arg Val Gln Gln Arg Val
            900                 905                 910         
Thr Ile Lys Lys Ala Leu Thr Leu Lys Tyr Gly Glu Glu Leu Ala Arg
        915                 920                 925             
Ala Lys Ala Val Ala Ser Lys Glu Ile Gly Lys Arg Lys Leu Glu Gln
    930                 935                 940                 
Asp Arg Phe Gly Pro Asn Lys Met Met Arg Leu Asp Ser Ser Pro Val
945                 950                 955                 960 
Ser Ser Pro Arg Lys His Ser Ala Glu Leu Ile Ala Met Glu Lys Arg
                965                 970                 975     
Arg Leu Gln Lys Leu Glu Tyr Glu Tyr Ala Leu Lys Ile Gln Lys Leu
            980                 985                 990         
Lys Glu Ala Arg Ala Leu Lys Ala Lys Glu Gln Gln Asn Ile Ser Pro
        995                 1000                1005            
Val Val Glu Glu Glu Pro Glu Phe Ser Leu Pro Gln Pro Ser Leu His
    1010                1015                1020                
Asp Leu Thr Gln Asp Lys Leu Thr Leu Asp Thr Glu Glu Asn Asp Val
1025                1030                1035                1040
Asp Asp Glu Ile Leu Ser Gly Ser Ser Arg Glu Arg Arg Arg Ser Phe
                1045                1050                1055    
Leu Glu Ser Asn Tyr Phe Thr Lys Pro Asn Leu Lys His Thr Asp Thr
            1060                1065                1070        
Ala Asn Lys Glu Cys Ile Asn Lys Leu Asn Lys Asn Thr Val Glu Lys
        1075                1080                1085            
Pro Glu Leu Phe Leu Gly Leu Lys Ile Gly Glu Leu Gln Lys Leu Tyr
    1090                1095                1100                
Ser Lys Ala Asp Ser Leu Lys Gln Leu Ile Leu Lys Thr Thr Thr Gly
1105                1110                1115                1120
Ile Thr Glu Lys Val Leu His Gly Gln Glu Ile Ser Val Asp Val Asp
                1125                1130                1135    
Phe Val Thr Ala Gln Ser Lys Thr Met Glu Val Lys Pro Cys Pro Phe
            1140                1145                1150        
Arg Pro Tyr His Ser Pro Leu Leu Val Phe Lys Ser Tyr Arg Phe Ser
        1155                1160                1165            
Pro Tyr Tyr Arg Thr Lys Glu Lys Leu Pro Leu Ser Ser Val Ser Tyr
    1170                1175                1180                
Ser Asn Met Ile Glu Pro Asp Gln Cys Phe Cys Arg Phe Asp Leu Thr
1185                1190                1195                1200
Gly Thr Cys Asn Asp Asp Asp Cys Gln Trp Gln His Ile Gln Asp Tyr
                1205                1210                1215    
Thr Leu Ser Arg Lys Gln Leu Phe Gln Asp Ile Leu Ser Tyr Asn Leu
            1220                1225                1230        
Ser Leu Ile Gly Cys Ala Glu Thr Ser Thr Asn Glu Glu Ile Thr Ala
        1235                1240                1245            
Ser Ala Glu Lys Tyr Val Glu Lys Leu Phe Gly Val Asn Lys Asp Arg
    1250                1255                1260                
Met Ser Met Asp Gln Met Ala Val Leu Leu Val Ser Asn Ile Asn Glu
1265                1270                1275                1280
Ser Lys Gly His Thr Pro Pro Phe Thr Thr Tyr Lys Asp Lys Arg Lys
                1285                1290                1295    
Trp Lys Pro Lys Phe Trp Arg Lys Pro Ile Ser Asp Asn Ser Phe Ser
            1300                1305                1310        
Ser Asp Glu Glu Gln Ser Thr Gly Pro Ile Lys Tyr Ala Phe Gln Pro
        1315                1320                1325            
Glu Asn Gln Ile Asn Val Pro Ala Leu Asp Thr Val Val Thr Pro Asp
    1330                1335                1340                
Asp Val Arg Tyr Phe Thr Asn Glu Thr Asp Asp Ile Ala Asn Leu Glu
1345                1350                1355                1360
Ala Ser Val Leu Glu Asn Pro Ser His Val Gln Leu Trp Leu Lys Leu
                1365                1370                1375    
Ala Tyr Lys Tyr Leu Asn Gln Asn Glu Gly Glu Cys Ser Glu Ser Leu
            1380                1385                1390        
Asp Ser Ala Leu Asn Val Leu Ala Arg Ala Leu Glu Asn Asn Lys Asp
        1395                1400                1405            
Asn Pro Glu Ile Trp Cys His Tyr Leu Arg Leu Phe Ser Lys Arg Gly
    1410                1415                1420                
Thr Lys Asp Glu Val Gln Glu Met Cys Glu Thr Ala Val Glu Tyr Ala
1425                1430                1435                1440
Pro Asp Tyr Gln Ser Phe Trp Thr Phe Leu His Leu Glu Ser Thr Phe
                1445                1450                1455    
Glu Glu Lys Asp Tyr Val Cys Glu Arg Met Leu Glu Phe Leu Met Gly
            1460                1465                1470        
Ala Ala Lys Gln Glu Thr Ser Asn Ile Leu Ser Phe Gln Leu Leu Glu
        1475                1480                1485            
Ala Leu Leu Phe Arg Val Gln Leu His Ile Phe Thr Gly Arg Cys Gln
    1490                1495                1500                
Ser Ala Leu Ala Ile Leu Gln Asn Ala Leu Lys Ser Ala Asn Asp Gly
1505                1510                1515                1520
Ile Val Ala Glu Tyr Leu Lys Thr Ser Asp Arg Cys Leu Ala Trp Leu
                1525                1530                1535    
Ala Tyr Ile His Leu Ile Glu Phe Asn Ile Leu Pro Ser Lys Phe Tyr
            1540                1545                1550        
Asp Pro Ser Asn Asp Asn Pro Ser Arg Ile Val Asn Thr Glu Ser Phe
        1555                1560                1565            
Val Met Pro Trp Gln Ala Val Gln Asp Val Lys Thr Asn Pro Asp Met
    1570                1575                1580                
Leu Leu Ala Val Phe Glu Asp Ala Val Lys Ala Cys Thr Asp Glu Ser
1585                1590                1595                1600
Leu Ala Val Glu Glu Arg Ile Glu Ala Cys Leu Pro Leu Tyr Thr Asn
                1605                1610                1615    
Met Ile Ala Leu His Gln Leu Leu Glu Arg Tyr Glu Ala Ala Met Glu
            1620                1625                1630        
Leu Cys Lys Ser Leu Leu Glu Ser Cys Pro Ile Asn Cys Gln Leu Leu
        1635                1640                1645            
Glu Ala Leu Val Ala Leu Tyr Leu Gln Thr Asn Gln His Asp Lys Ala
    1650                1655                1660                
Arg Ala Val Trp Leu Thr Ala Phe Glu Lys Asn Pro Gln Asn Ala Glu
1665                1670                1675                1680
Val Phe Tyr His Met Cys Lys Phe Phe Ile Leu Gln Asn Arg Gly Asp
                1685                1690                1695    
Asn Leu Leu Pro Phe Leu Arg Lys Phe Ile Ala Ser Phe Phe Lys Pro
            1700                1705                1710        
Gly Phe Glu Lys Tyr Asn Asn Leu Asp Leu Phe Arg Tyr Leu Leu Asn
        1715                1720                1725            
Ile Pro Gly Pro Ile Asp Ile Pro Ser Arg Leu Cys Lys Gly Asn Phe
    1730                1735                1740                
Asp Asp Asp Met Phe Asn His Gln Val Pro Tyr Leu Trp Leu Ile Tyr
1745                1750                1755                1760
Cys Leu Cys His Pro Leu Gln Ser Ser Ile Lys Glu Thr Val Glu Ala
                1765                1770                1775    
Tyr Glu Ala Ala Leu Gly Val Ala Met Arg Cys Asp Ile Val Gln Lys
            1780                1785                1790        
Ile Trp Met Asp Tyr Leu Val Phe Ala Asn Asn Arg Ala Ala Gly Ser
        1795                1800                1805            
Arg Asn Lys Val Gln Glu Phe Lys Phe Phe Thr Asp Leu Val Asn Arg
    1810                1815                1820                
Cys Leu Val Thr Val Pro Ala Arg Tyr Pro Ile Pro Phe Ser Ser Ala
1825                1830                1835                1840
Asp Tyr Trp Ser Asn Tyr Glu Phe His Asn Arg Val Ile Phe Phe Tyr
                1845                1850                1855    
Leu Ser Cys Val Pro Lys Thr Gln His Ser Lys Thr Leu Glu Arg Phe
            1860                1865                1870        
Cys Ser Val Met Pro Ala Asn Ser Gly Leu Ala Leu Arg Leu Leu Gln
        1875                1880                1885            
His Glu Trp Glu Glu Ser Asn Val Gln Ile Leu Lys Leu Gln Ala Lys
    1890                1895                1900                
Met Phe Thr Tyr Asn Ile Pro Thr Cys Leu Ala Thr Trp Lys Met
1905                1910                1915                


<210> 7864
<211> 5689
<212> PRT
<213> Homo sapiens

<400> 7864
Met Asp Gln Ala Gln Val Ser Pro Leu Ala Leu Asp Asn Met Gly Leu
 1               5                  10                  15      
Ala Gln Asp Asn Pro Leu Ala Leu Asp Asn Met Ser Leu Asp Gln Val
            20                  25                  30          
Ser Leu Ala Met Ala Asn Thr Val Leu Ala Gln Val Ser His Leu Ala
        35                  40                  45              
Met Ala Asn Met Gly Leu Asp Arg His Leu Ala Leu Asp Asn Met Gly
    50                  55                  60                  
Gln Ala Gln Val Asn Pro Leu Ala Leu Ala Asn Met Asp Gln Ala Gln
65                  70                  75                  80  
Val Ser Pro Leu Ala Leu Asp Asn Met Gly Leu Ala Gln Asp Asn Pro
                85                  90                  95      
Leu Ala Leu Asp Ser Met Ser Leu Asp His Ile Ser Pro Ala Met Ala
            100                 105                 110         
Asn Met Val Leu Ala Gln Val Asn His Leu Ala Met Val Asn Met Gly
        115                 120                 125             
Gln Val Arg Asp Arg His Leu Ala Leu Asp Asn Thr Gly Gln Ala Gln
    130                 135                 140                 
Val Asn Thr Leu Ala Leu Asp Asn Met Asp Gln Ala Gln Val Ser Pro
145                 150                 155                 160 
Val Ala Leu Asp Asn Met Gly Leu Ala Gln Asp Asn Thr Leu Val Leu
                165                 170                 175     
Asp Asn Met Ser Leu Asp His Ile Ser Leu Ala Met Ala Asn Met Val
            180                 185                 190         
Leu Ala Gln Val Ser His Leu Ala Met Val Asn Met Gly Gln Val Gln
        195                 200                 205             
Asp Arg Leu Leu Asp Leu Asp Asn Thr Gly Gln Ala Gln Val Asn Pro
    210                 215                 220                 
Leu Ala Leu Ala Asn Met Asp Gln Ala Gln Val Ser Pro Leu Ala Leu
225                 230                 235                 240 
Asp Asn Met Ser Gln Ala Gln Glu Asn Pro Leu Ala Leu Asp Ser Met
                245                 250                 255     
Ser Leu Asp Gln Val Ser Leu Ile Met Ala Asn Met Val Leu Ala Gln
            260                 265                 270         
Val Ser His Leu Ala Met Val Asn Met Gly Leu Val Gln Asp Arg Gln
        275                 280                 285             
Leu Ala Leu Asp Asn Thr Gly Gln Ala Gln Ala Asn Thr Gln Ala Leu
    290                 295                 300                 
Asp Asn Met Asp Gln Ala Gln Ile Ser Pro Leu Ala Leu Asp Asn Met
305                 310                 315                 320 
Gly Leu Val Gln Asp Asn Pro Leu Val Leu Asp Asn Met Ser Leu Asp
                325                 330                 335     
His Val Ser Leu Ala Met Ala Asn Met Val Leu Ala Gln Val Asn His
            340                 345                 350         
Leu Ala Met Val Asn Met Gly Gln Ile Gln Asp Arg His Leu Asp Leu
        355                 360                 365             
Asp Asn Thr Gly Gln Ala Gln Val Ser Pro Leu Ala Leu Ala Asn Met
    370                 375                 380                 
Asp Arg Ala Gln His Glu Tyr Arg Ser Gly Gln Ser Ser Tyr Gly Gln
385                 390                 395                 400 
His Gly Thr Gly Ser Ser Gln Ser Ser Gly Cys Gly Gln His Glu Ser
                405                 410                 415     
Gly Ser Gly Pro Thr Thr Ser Phe Gly Gln His Val Ser Gly Ser Asp
            420                 425                 430         
Asn Phe Ser Ser Ser Gly Gln His Ile Ser Asp Ser Gly Gln Ser Thr
        435                 440                 445             
Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln Ser Thr Gly Leu Gly
    450                 455                 460                 
Gln Gly Glu Ser Gln Gln Val Glu Ser Gly Ser Thr Val His Gly Arg
465                 470                 475                 480 
Gln Glu Thr Thr His Gly Gln Thr Ile Asn Thr Thr Arg His Ser Gln
                485                 490                 495     
Ser Gly Gln Gly Gln Ser Thr Gln Thr Gly Ser Arg Val Thr Arg Arg
            500                 505                 510         
Arg Arg Ser Ser Gln Ser Glu Asn Ser Asp Ser Glu Val His Ser Lys
        515                 520                 525             
Val Ser His Arg His Ser Glu His Ile His Thr Gln Ala Gly Ser His
    530                 535                 540                 
Tyr Pro Lys Ser Gly Ser Thr Val Arg Arg Arg Gln Gly Thr Thr His
545                 550                 555                 560 
Gly Gln Arg Gly Asp Thr Thr Arg His Gly His Ser Gly His Gly Gln
                565                 570                 575     
Ser Thr Gln Thr Gly Ser Arg Thr Ser Gly Arg Gln Arg Phe Ser His
            580                 585                 590         
Ser Asp Ala Thr Asp Ser Glu Val His Ser Gly Val Ser His Arg Pro
        595                 600                 605             
His Ser Gln Glu Gln Thr His Ser Gln Ala Gly Ser Gln His Gly Glu
    610                 615                 620                 
Ser Glu Ser Thr Val His Glu Arg His Glu Thr Thr Tyr Gly Gln Thr
625                 630                 635                 640 
Gly Glu Ala Thr Gly His Gly His Ser Gly His Gly Gln Ser Thr Gln
                645                 650                 655     
Arg Gly Ser Arg Thr Thr Gly Arg Arg Gly Ser Gly His Ser Glu Ser
            660                 665                 670         
Ser Asp Ser Glu Val His Ser Gly Gly Ser His Arg Pro Gln Ser Gln
        675                 680                 685             
Glu Gln Thr His Gly Gln Ala Gly Ser Gln His Gly Glu Ser Gly Ser
    690                 695                 700                 
Thr Val His Gly Arg His Gly Thr Thr His Gly Gln Thr Gly Asp Thr
705                 710                 715                 720 
Thr Arg His Ala His Tyr His His Gly Lys Ser Thr Gln Arg Gly Ser
                725                 730                 735     
Ser Thr Thr Gly Arg Arg Gly Ser Gly His Ser Glu Ser Ser Asp Ser
            740                 745                 750         
Glu Val His Ser Gly Gly Ser His Thr His Ser Gly His Thr His Gly
        755                 760                 765             
Gln Ser Gly Ser Gln His Gly Glu Ser Glu Ser Ile Ile His Asp Arg
    770                 775                 780                 
His Arg Ile Thr His Gly Gln Thr Gly Asp Thr Thr Arg His Ser Tyr
785                 790                 795                 800 
Ser Gly His Glu Gln Thr Thr Gln Thr Gly Ser Arg Thr Thr Gly Arg
                805                 810                 815     
Gln Arg Thr Ser His Ser Glu Ser Thr Asp Ser Glu Val His Ser Gly
            820                 825                 830         
Gly Ser His Arg Pro His Ser Arg Glu His Thr Tyr Gly Gln Ala Gly
        835                 840                 845             
Ser Gln His Glu Glu Pro Glu Phe Thr Val His Glu Arg His Gly Thr
    850                 855                 860                 
Thr His Gly Gln Ile Gly Asp Thr Thr Gly His Ser His Ser Gly His
865                 870                 875                 880 
Gly Gln Ser Thr Gln Arg Gly Ser Arg Thr Thr Gly Arg Gln Arg Ser
                885                 890                 895     
Ser His Ser Glu Ser Ser Asp Ser Glu Val His Ser Gly Val Ser His
            900                 905                 910         
Thr His Thr Gly His Thr His Gly Gln Ala Gly Ser Gln His Gly Gln
        915                 920                 925             
Ser Glu Ser Ile Val Pro Glu Arg His Gly Thr Thr His Gly Gln Thr
    930                 935                 940                 
Gly Asp Thr Thr Arg His Ala His Tyr His His Gly Leu Thr Thr Gln
945                 950                 955                 960 
Thr Gly Ser Arg Thr Thr Gly Arg Arg Gly Ser Gly His Ser Glu Tyr
                965                 970                 975     
Ser Asp Ser Glu Gly Tyr Ser Gly Val Ser His Thr His Ser Gly His
            980                 985                 990         
Thr His Gly Gln Ala Arg Ser Gln His Gly Glu Ser Glu Ser Ile Val
        995                 1000                1005            
His Glu Arg His Gly Thr Ile His Gly Gln Thr Gly Asp Thr Thr Arg
    1010                1015                1020                
His Ala His Ser Gly His Gly Gln Ser Thr Gln Thr Gly Ser Arg Thr
1025                1030                1035                1040
Thr Gly Arg Arg Ser Ser Gly His Ser Glu Tyr Ser Asp Ser Glu Gly
                1045                1050                1055    
His Ser Gly Phe Ser Gln Arg Pro His Ser Arg Gly His Thr His Gly
            1060                1065                1070        
Gln Ala Gly Ser Gln His Gly Glu Ser Glu Ser Ile Val Asp Glu Arg
        1075                1080                1085            
His Gly Thr Thr His Gly Gln Thr Gly Asp Thr Ser Gly His Ser Gln
    1090                1095                1100                
Ser Gly His Gly Gln Ser Thr Gln Ser Gly Ser Ser Thr Thr Gly Arg
1105                1110                1115                1120
Arg Arg Ser Gly His Ile Met Asp Lys Pro Tyr Arg Gln Gly Pro Gly
                1125                1130                1135    
Gln Leu Glu Glu Gly Asp Leu Ala Thr Val Ser Thr Val Thr Val Lys
            1140                1145                1150        
Gly Pro Gln Gly Ser His Thr His Ile Gln Asp Thr Leu Thr Val Lys
        1155                1160                1165            
Leu Asp Leu Thr Ile Gln Ser Gln Asp Pro Gln Phe Met Arg Asp Thr
    1170                1175                1180                
Glu Leu Leu Met Asp Lys Gln Gln Ile Pro Leu Asp Met Ala Thr Leu
1185                1190                1195                1200
Val Met Asp Ser Pro His Arg Glu Gly Pro Gly Gln Leu Glu Glu Gly
                1205                1210                1215    
His Leu Ala Thr Val Ser Thr Val Thr Val Lys Gly Thr Gln Gly Ser
            1220                1225                1230        
His Thr His Ile Gln Asp Thr Leu Met Ala Lys Pro Asp Leu Asn Met
        1235                1240                1245            
Glu Ser Gln Asp Pro Gln Phe Met Arg Asp Thr Glu Leu Leu Met Asp
    1250                1255                1260                
Arg Gln Glu Ile Pro Leu Asp Met Leu Thr Leu Val Met Asp Ser Pro
1265                1270                1275                1280
His Arg Glu Gly Gln Gly Gln Leu Glu Glu Gly Asp Leu Ala Thr Val
                1285                1290                1295    
Ser Pro Val Thr Val Lys Cys Thr Gln Gly Ser His Thr His Ile Gln
            1300                1305                1310        
Asp Thr Leu Met Ala Lys Pro Asp Leu Asn Met Glu Ser Gln Asp Leu
        1315                1320                1325            
Pro Phe Thr Gly Asp Arg Glu Leu Tyr Met Asp Arg Gln Glu Ile Pro
    1330                1335                1340                
Leu Asp Met Ala Ser Leu Val Met Asp Ser Pro His Arg Gln Val Pro
1345                1350                1355                1360
Gly Gln Leu Glu Asp Lys Asp Leu Val Thr Val Ser Pro Val Ile Val
                1365                1370                1375    
Lys Cys Thr Gln Arg Pro His Pro His Ile Gln Asp Thr Leu Thr Ala
            1380                1385                1390        
Lys Pro Asp Leu Asp Met Asp Ser Gln Asp Pro Gln Val Met Gly Asp
        1395                1400                1405            
Arg Glu Leu Leu Met Asp Arg Gln Glu Ile Pro Leu Asp Met Pro Thr
    1410                1415                1420                
Met Val Met Asp Asn Pro His Arg Glu Gly Pro Gly Gln Leu Glu Glu
1425                1430                1435                1440
Gly Asp Leu Ala Thr Val Ser Pro Val Thr Val Lys Cys Thr His Gly
                1445                1450                1455    
Ala His Thr His Ile Gln Asp Thr Phe Arg Ala Lys Leu Asp Leu Asn
            1460                1465                1470        
Lys Asp Ser Gln Asp Pro Gln Phe Met Gly Asp Trp Lys Leu Leu Met
        1475                1480                1485            
Asp Arg Gln Glu Ile Pro Leu Asp Met Ala Ile Leu Val Met Asp Asn
    1490                1495                1500                
Pro His Arg Gln Val Pro Asp Leu Val Glu Gln Val Ile Phe Ser His
1505                1510                1515                1520
Ile Val Val Lys Gly Lys Gly Met Asp Gln Val Arg Phe Gly Asn Met
                1525                1530                1535    
Ala Ala Met Asp Leu Gln Asn Met Thr Met Gly Thr Leu Val Ser Lys
            1540                1545                1550        
Ala Thr Lys Arg Thr Gly Arg His Ser Leu Asn His Glu Gln Ser Met
        1555                1560                1565            
Val Ser Tyr Glu His Ser Val Asp Ser Gln Tyr Gln Ser Arg Pro Ile
    1570                1575                1580                
Ile Ile Arg Ser Gln Glu Ser Ser His Gly His Ser Ile Val Thr His
1585                1590                1595                1600
Lys Gln Ser Asn Asn Thr Tyr Val Gln Pro Gly Tyr Asn Thr Ala Arg
                1605                1610                1615    
Arg Glu Gly Cys Thr His Ser Gln Ser Asn Asp His Leu Gly Phe Gly
            1620                1625                1630        
His Gly Gln Ser Ile Ser Val His Gly His Ser Lys Ser Ser Ser Ile
        1635                1640                1645            
Arg Lys Gln Glu Ser His Thr Asp Asn Lys Lys His Ser Glu Asp Trp
    1650                1655                1660                
Glu Lys Asp Thr His Glu Gln Leu Gly Ser Arg His Gly Lys Leu Glu
1665                1670                1675                1680
Phe Asn Thr Ile Gly Ile His Gly Ser Ser Gln Gln His Phe Gly Asp
                1685                1690                1695    
Thr Thr Phe His Gly Gln Val His Ile Tyr Cys Gln Lys Met Ser Thr
            1700                1705                1710        
Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys Gln Tyr Ser
        1715                1720                1725            
Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu Leu Lys Glu
    1730                1735                1740                
Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro Asp Asp Pro
1745                1750                1755                1760
Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp His Asn Lys
                1765                1770                1775    
Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys Leu Ala Gln
            1780                1785                1790        
Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile Ser Gly His
        1795                1800                1805            
Lys His Arg Lys His Ser His His Asp Lys His Glu Asp Asn Lys Gln
    1810                1815                1820                
Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu Glu Arg Arg
1825                1830                1835                1840
Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro Arg Glu Thr
                1845                1850                1855    
Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu Arg Lys Gly
            1860                1865                1870        
Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn His His Asn
        1875                1880                1885            
Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg Leu Gly Asp
    1890                1895                1900                
Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu Asp Asn Glu
1905                1910                1915                1920
Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr Gln Lys Trp
                1925                1930                1935    
Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln Asp Glu Ala
            1940                1945                1950        
Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile Tyr Glu Arg
        1955                1960                1965            
Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn Arg Ser Arg
    1970                1975                1980                
His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg Thr Arg Lys
1985                1990                1995                2000
Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser
                2005                2010                2015    
Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn His His Gly
            2020                2025                2030        
Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro Arg Ser His
        2035                2040                2045            
Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser Ser Arg Gln
    2050                2055                2060                
Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln Thr Ala Ser
2065                2070                2075                2080
Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Gly
                2085                2090                2095    
His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr Gly Arg Gly
            2100                2105                2110        
Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly Ser Ser Gly
        2115                2120                2125            
Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser Asp Thr Gln
    2130                2135                2140                
Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln Ser His Gln
2145                2150                2155                2160
Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser
                2165                2170                2175    
Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser Ala His Gly
            2180                2185                2190        
Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His His Glu Gln
        2195                2200                2205            
Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr
    2210                2215                2220                
Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser His
2225                2230                2235                2240
His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser His His Ser
                2245                2250                2255    
His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly
            2260                2265                2270        
Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp
        2275                2280                2285            
Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Gln Ala
    2290                2295                2300                
Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser Ser Gly Pro
2305                2310                2315                2320
Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser
                2325                2330                2335    
Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg
            2340                2345                2350        
Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly Ser Arg His
        2355                2360                2365            
Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp
    2370                2375                2380                
Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser Ser Ser Gly
2385                2390                2395                2400
Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg
                2405                2410                2415    
His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser Arg His Ser
            2420                2425                2430        
Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His
        2435                2440                2445            
Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly His Ser Glu
    2450                2455                2460                
Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly His His
2465                2470                2475                2480
Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Glu Arg Ser
                2485                2490                2495    
Arg Arg Ser Gly Ser Phe Leu Tyr Gln Gly Arg Ser Asp Ala Ser Arg
            2500                2505                2510        
Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg Asn Glu Glu
        2515                2520                2525            
Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala
    2530                2535                2540                
Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala Gly Gln Gly Gln
2545                2550                2555                2560
Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser Ser Val Ser Gln
                2565                2570                2575    
Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly
            2580                2585                2590        
Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu Gln Ser Arg His
        2595                2600                2605            
Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly
    2610                2615                2620                
His Ser Ala Asp Ser Ser Arg Gln Ser Gly Thr Pro His Ala Glu Thr
2625                2630                2635                2640
Ser Ser Gly Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser
                2645                2650                2655    
Pro Gly Glu Arg His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser
            2660                2665                2670        
Arg His Ser Gly Ile Pro Arg Arg Gln Ala Ser Ser Ala Val Arg Asp
        2675                2680                2685            
Ser Gly His Trp Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly
    2690                2695                2700                
His Ser Glu Glu Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Asp
2705                2710                2715                2720
Gly Pro His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Trp Ser Gly
                2725                2730                2735    
Gly Arg Ser Gly Arg Ser Gly Ser Phe Ile Tyr Gln Val Ser Thr His
            2740                2745                2750        
Glu Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg
        2755                2760                2765            
Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser
    2770                2775                2780                
Ala Ser Gln Glu Gly Gln Asp Thr Ile Arg Ala His Pro Gly Ser Arg
2785                2790                2795                2800
Arg Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser
                2805                2810                2815    
Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser
            2820                2825                2830        
Asp Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr
        2835                2840                2845            
Arg Lys Asp Lys Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser Arg
    2850                2855                2860                
His His Glu Ala Ala Ser Trp Ala Asp Ser Ser Arg His Ser Gln Val
2865                2870                2875                2880
Gly Gln Glu Gln Ser Ser Gly Ser Arg Thr Ser Arg His Gln Gly Ser
                2885                2890                2895    
Ser Val Ser Gln Asp Ser Asp Ser Glu Arg His Ser Asp Asp Ser Glu
            2900                2905                2910        
Arg Leu Ser Gly Ser Ala Ser Arg Asn His His Gly Ser Ser Arg Glu
        2915                2920                2925            
Gln Ser Arg Asp Gly Ser Arg His Pro Gly Phe His Gln Glu Asp Arg
    2930                2935                2940                
Ala Ser His Gly His Ser Ala Asp Ser Ser Arg Gln Ser Gly Thr His
2945                2950                2955                2960
His Thr Glu Ser Ser Ser His Gly Gln Ala Val Ser Ser His Glu Gln
                2965                2970                2975    
Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg His Gln Gln Ser
            2980                2985                2990        
Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Arg Gln Ala Ser Ser
        2995                3000                3005            
Ala Val Arg Asp Ser Gly His Arg Gly Ser Ser Gly Ser Gln Val Thr
    3010                3015                3020                
Asn Ser Glu Gly His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala
3025                3030                3035                3040
His Gly Gln Ala Gly Pro His Gln Gln Ser His Lys Glu Ser Ala Arg
                3045                3050                3055    
Gly Gln Ser Gly Glu Ser Ser Gly Arg Ser Arg Ser Phe Leu Tyr Gln
            3060                3065                3070        
Val Ser Ser His Glu Gln Ser Glu Ser Thr His Gly Gln Thr Ala Pro
        3075                3080                3085            
Ser Thr Gly Gly Arg Gln Gly Ser Arg His Glu Gln Ala Arg Asn Ser
    3090                3095                3100                
Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His
3105                3110                3115                3120
Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser
                3125                3130                3135    
Val Asp Arg Ser Gly His Ser Gly Tyr His His Ser His Thr Thr Pro
            3140                3145                3150        
Gln Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly Pro Arg Ser Ala
        3155                3160                3165            
Ser Arg Gln Thr Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His
    3170                3175                3180                
Ser Gly Ser Arg His His Glu Pro Ser Thr Arg Ala Gly Ser Ser Arg
3185                3190                3195                3200
His Ser Gln Val Gly Gln Gly Glu Ser Ala Gly Ser Lys Thr Ser Arg
                3205                3210                3215    
Arg Gln Gly Ser Ser Val Ser Gln Asp Arg Asp Ser Glu Gly His Ser
            3220                3225                3230        
Glu Asp Ser Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His Tyr Gly
        3235                3240                3245            
Ser Ala Arg Glu Gln Ser Arg His Gly Ser Arg Asn Pro Arg Ser His
    3250                3255                3260                
Gln Glu Asp Arg Ala Ser His Gly His Ser Ala Glu Ser Ser Arg Gln
3265                3270                3275                3280
Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly Gly Gln Ala Ala Ser
                3285                3290                3295    
Ser Gln Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His Gly Ser Arg
            3300                3305                3310        
His Gln Gln Ser Ala Asp Ser Ser Thr Asp Ser Gly Thr Gly Arg Arg
        3315                3320                3325            
Gln Asp Ser Ser Val Val Gly Asp Ser Gly Asn Arg Gly Ser Ser Gly
    3330                3335                3340                
Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Glu Ser Asp Thr Gln
3345                3350                3355                3360
Ser Val Ser Ala His Gly Gln Ala Gly Pro His Gln Gln Ser His Gln
                3365                3370                3375    
Glu Ser Thr Arg Gly Gln Ser Gly Glu Arg Ser Gly Arg Ser Gly Ser
            3380                3385                3390        
Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ala His Gly
        3395                3400                3405            
Arg Thr Gly Pro Ser Thr Gly Gly Arg Gln Arg Ser Arg His Glu Gln
    3410                3415                3420                
Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr
3425                3430                3435                3440
Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Ser His
                3445                3450                3455    
Tyr Glu Gln Ser Val Asp Ser Ser Gly His Ser Gly Ser His His Ser
            3460                3465                3470        
His Thr Thr Ser Gln Glu Arg Ser Asp Val Ser Arg Gly Gln Ser Gly
        3475                3480                3485            
Ser Arg Ser Val Ser Arg Gln Thr Arg Asn Glu Lys Gln Ser Gly Asp
    3490                3495                3500                
Gly Ser Arg His Ser Gly Ser Arg His His Glu Ala Ser Ser Arg Ala
3505                3510                3515                3520
Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser Ser Gly Pro
                3525                3530                3535    
Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser
            3540                3545                3550        
Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg
        3555                3560                3565            
Asn His Leu Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His
    3570                3575                3580                
Pro Gly Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala Asp
3585                3590                3595                3600
Ser Ser Arg Gln Ser Gly Thr Arg His Thr Glu Ser Ser Ser Arg Gly
                3605                3610                3615    
Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg
            3620                3625                3630        
His Gly Ser His His Gln Leu Gln Ser Ala Asp Ser Ser Arg His Ser
        3635                3640                3645            
Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His
    3650                3655                3660                
Arg Gly Tyr Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu
3665                3670                3675                3680
Asp Ser Asp Thr Gln Ser Val Ser Ala Gln Gly Lys Ala Gly Pro His
                3685                3690                3695    
Gln Gln Ser His Lys Glu Ser Ala Arg Gly Gln Ser Gly Glu Ser Ser
            3700                3705                3710        
Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser
        3715                3720                3725            
Glu Ser Thr His Gly Gln Ser Ala Pro Ser Thr Gly Gly Arg Gln Gly
    3730                3735                3740                
Ser His Tyr Asp Gln Ala Gln Asp Ser Ser Arg His Ser Ala Ser Gln
3745                3750                3755                3760
Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Pro Ser Arg Gly Gly
                3765                3770                3775    
Arg Gln Gly Ser His Gln Glu Gln Ser Val Asp Arg Ser Gly His Ser
            3780                3785                3790        
Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser
        3795                3800                3805            
Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Lys Thr Tyr Asp Lys
    3810                3815                3820                
Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser His His His Glu
3825                3830                3835                3840
Ala Ser Ser Trp Ala Asp Ser Ser Arg His Ser Leu Val Gly Gln Gly
                3845                3850                3855    
Gln Ser Ser Gly Pro Arg Thr Ser Arg Pro Arg Gly Ser Ser Val Ser
            3860                3865                3870        
Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu Arg Arg Ser
        3875                3880                3885            
Gly Ser Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg
    3890                3895                3900                
Asp Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His
3905                3910                3915                3920
Gly His Ser Ala Glu Ser Ser Arg Gln Ser Gly Thr His His Ala Glu
                3925                3930                3935    
Asn Ser Ser Gly Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser
            3940                3945                3950        
Ser Ala Gly Glu Arg His Gly Ser His His Gln Gln Ser Ala Asp Ser
        3955                3960                3965            
Ser Arg His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg
    3970                3975                3980                
Asp Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu
3985                3990                3995                4000
Gly His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln
                4005                4010                4015    
Ala Gly Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser
            4020                4025                4030        
Ala Gly Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr
        4035                4040                4045            
His Glu Gln Ser Glu Ser Ala His Gly Arg Thr Gly Thr Ser Thr Gly
    4050                4055                4060                
Gly Arg Gln Gly Ser His His Lys Gln Ala Arg Asp Ser Ser Arg His
4065                4070                4075                4080
Ser Thr Ser Gln Glu Gly Gln Asp Thr Ile His Gly His Pro Gly Ser
                4085                4090                4095    
Ser Ser Gly Gly Arg Gln Gly Ser His Tyr Glu Gln Leu Val Asp Arg
            4100                4105                4110        
Ser Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg
        4115                4120                4125            
Ser Asp Ala Ser His Gly His Ser Gly Ser Arg Ser Ala Ser Arg Gln
    4130                4135                4140                
Thr Arg Asn Asp Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser
4145                4150                4155                4160
Arg His His Glu Ala Ser Ser Arg Ala Asp Ser Ser Gly His Ser Gln
                4165                4170                4175    
Val Gly Gln Gly Gln Ser Glu Gly Pro Arg Thr Ser Arg Asn Trp Gly
            4180                4185                4190        
Ser Ser Phe Ser Gln Asp Ser Asp Ser Gln Gly His Ser Glu Asp Ser
        4195                4200                4205            
Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His Gly Ser Ala Gln
    4210                4215                4220                
Glu Gln Leu Arg Asp Gly Ser Arg His Pro Arg Ser His Gln Glu Asp
4225                4230                4235                4240
Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg Gln Ser Gly Thr
                4245                4250                4255    
Arg His Thr Gln Thr Ser Ser Gly Gly Gln Ala Ala Ser Ser His Glu
            4260                4265                4270        
Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser His His Gln Gln
        4275                4280                4285            
Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His Gly Gln Ala Ser
    4290                4295                4300                
Ser Ala Val Arg Asp Ser Gly His Arg Gly Tyr Ser Gly Ser Gln Ala
4305                4310                4315                4320
Ser Asp Asn Glu Gly His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser
                4325                4330                4335    
Ala His Gly Gln Ala Gly Ser His Gln Gln Ser His Gln Glu Ser Ala
            4340                4345                4350        
Arg Gly Arg Ser Gly Glu Thr Ser Gly His Ser Gly Ser Phe Leu Tyr
        4355                4360                4365            
Gln Val Ser Thr His Glu Gln Ser Glu Ser Ser His Gly Trp Thr Gly
    4370                4375                4380                
Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu Gln Ala Gln Asp
4385                4390                4395                4400
Ser Ser Arg His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly
                4405                4410                4415    
His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Tyr His His Glu His
            4420                4425                4430        
Ser Val Asp Ser Ser Gly His Ser Gly Ser His His Ser His Thr Thr
        4435                4440                4445            
Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser
    4450                4455                4460                
Ala Ser Arg Thr Thr Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg
4465                4470                4475                4480
His Ser Gly Ser Arg His His Glu Ala Ser Thr His Ala Asp Ile Ser
                4485                4490                4495    
Arg His Ser Gln Ala Val Gln Gly Gln Ser Glu Gly Ser Arg Arg Ser
            4500                4505                4510        
Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His
        4515                4520                4525            
Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser Arg Asn His His
    4530                4535                4540                
Gly Ser Ala Gln Glu Gln Leu Arg Asp Gly Ser Arg His Pro Arg Ser
4545                4550                4555                4560
His Gln Glu Asp Arg Ala Gly His Gly His Ser Ala Asp Ser Ser Arg
                4565                4570                4575    
Gln Ser Gly Thr Arg His Thr Gln Thr Ser Ser Gly Gly Gln Ala Ala
            4580                4585                4590        
Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His Gly Ser
        4595                4600                4605            
His His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile Gly His
    4610                4615                4620                
Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Gly His Arg Gly Tyr Ser
4625                4630                4635                4640
Gly Ser Gln Ala Ser Asp Asn Glu Gly His Ser Glu Asp Ser Asp Thr
                4645                4650                4655    
Gln Ser Val Ser Ala His Gly Gln Ala Gly Ser His Gln Gln Ser His
            4660                4665                4670        
Gln Glu Ser Ala Arg Gly Arg Ser Gly Glu Thr Ser Gly His Ser Gly
        4675                4680                4685            
Ser Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser Ser His
    4690                4695                4700                
Gly Trp Thr Gly Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu
4705                4710                4715                4720
Gln Ala Gln Asp Ser Ser Arg His Ser Ala Ser Gln Tyr Gly Gln Asp
                4725                4730                4735    
Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln Gly Tyr
            4740                4745                4750        
His His Glu His Ser Val Asp Ser Ser Gly His Ser Gly Ser His His
        4755                4760                4765            
Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser Arg Gly Gln Ser
    4770                4775                4780                
Gly Ser Arg Ser Ala Ser Arg Thr Thr Arg Asn Glu Glu Gln Ser Gly
4785                4790                4795                4800
Asp Ser Ser Arg His Ser Val Ser Arg His His Glu Ala Ser Thr His
                4805                4810                4815    
Ala Asp Ile Ser Arg His Ser Gln Ala Val Gln Gly Gln Ser Glu Gly
            4820                4825                4830        
Ser Arg Arg Ser Arg Arg Gln Gly Ser Ser Val Ser Gln Asp Ser Asp
        4835                4840                4845            
Ser Glu Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser Ala Ser
    4850                4855                4860                
Arg Asn His Arg Gly Ser Val Gln Glu Gln Ser Arg His Gly Ser Arg
4865                4870                4875                4880
His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His Ser Ala
                4885                4890                4895    
Asp Arg Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Gly
            4900                4905                4910        
Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu
        4915                4920                4925            
Arg His Gly Ser Arg His Gln Gln Ser Ala Asp Ser Ser Arg His Ser
    4930                4935                4940                
Gly Ile Pro Arg Gly Gln Ala Ser Ser Ala Val Arg Asp Ser Arg His
4945                4950                4955                4960
Trp Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu
                4965                4970                4975    
Glu Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala Gly Pro His
            4980                4985                4990        
Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly Gly Arg Ser
        4995                5000                5005            
Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser
    5010                5015                5020                
Glu Ser Ala His Gly Arg Thr Arg Thr Ser Thr Gly Arg Arg Gln Gly
5025                5030                5035                5040
Ser His His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln
                5045                5050                5055    
Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Arg Gly
            5060                5065                5070        
Arg Gln Gly Ser His Tyr Glu Gln Ser Val Asp Arg Ser Gly His Ser
        5075                5080                5085            
Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser
    5090                5095                5100                
Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Asp
5105                5110                5115                5120
Glu Gln Ser Gly Asp Gly Ser Arg His Ser Trp Ser His His His Glu
                5125                5130                5135    
Ala Ser Thr Gln Ala Asp Ser Ser Arg His Ser Gln Ser Gly Gln Gly
            5140                5145                5150        
Gln Ser Ala Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser
        5155                5160                5165            
Gln Asp Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser
    5170                5175                5180                
Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu Gln Ser Arg
5185                5190                5195                5200
Asp Gly Ser Arg His Pro Thr Ser His His Glu Asp Arg Ala Gly His
                5205                5210                5215    
Gly His Ser Ala Glu Ser Ser Arg Gln Ser Gly Thr His His Ala Glu
            5220                5225                5230        
Asn Ser Ser Gly Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser
        5235                5240                5245            
Ser Ala Gly Glu Arg His Gly Ser His His Gln Gln Ser Ala Asp Ser
    5250                5255                5260                
Ser Arg His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg
5265                5270                5275                5280
Asp Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu
                5285                5290                5295    
Gly His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Ala His Gly Gln
            5300                5305                5310        
Ala Gly Pro His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser
        5315                5320                5325            
Ala Gly Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr
    5330                5335                5340                
His Glu Gln Ser Glu Ser Ala His Gly Arg Ala Gly Pro Ser Thr Gly
5345                5350                5355                5360
Gly Arg Gln Gly Ser Arg His Glu Gln Ala Arg Asp Ser Ser Arg His
                5365                5370                5375    
Ser Ala Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser
            5380                5385                5390        
Arg Arg Gly Gly Arg Gln Gly Ser Tyr His Glu Gln Ser Val Asp Arg
        5395                5400                5405            
Ser Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg
    5410                5415                5420                
Ser Asp Ala Ser His Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Glu
5425                5430                5435                5440
Thr Arg Asn Glu Glu Gln Ser Gly Asp Gly Ser Arg His Ser Gly Ser
                5445                5450                5455    
Arg His His Glu Ala Ser Thr Gln Ala Asp Ser Ser Arg His Ser Gln
            5460                5465                5470        
Ser Gly Gln Gly Glu Ser Ala Gly Ser Arg Arg Ser Arg Arg Gln Gly
        5475                5480                5485            
Ser Ser Val Ser Gln Asp Ser Asp Ser Glu Ala Tyr Pro Glu Asp Ser
    5490                5495                5500                
Glu Arg Arg Ser Glu Ser Ala Ser Arg Asn His His Gly Ser Ser Arg
5505                5510                5515                5520
Glu Gln Ser Arg Asp Gly Ser Arg His Pro Gly Ser Ser His Arg Asp
                5525                5530                5535    
Thr Ala Ser His Val Gln Ser Ser Pro Val Gln Ser Asp Ser Ser Thr
            5540                5545                5550        
Ala Lys Glu His Gly His Phe Ser Ser Leu Ser Gln Asp Ser Ala Tyr
        5555                5560                5565            
His Ser Gly Ile Gln Ser Arg Gly Ser Pro His Ser Ser Ser Ser Tyr
    5570                5575                5580                
His Tyr Gln Ser Glu Gly Thr Glu Arg Gln Lys Gly Gln Ser Gly Leu
5585                5590                5595                5600
Val Trp Arg His Gly Ser Tyr Gly Ser Ala Asp Tyr Asp Tyr Gly Glu
                5605                5610                5615    
Ser Gly Phe Arg His Ser Gln His Gly Ser Val Ser Tyr Asn Ser Asn
            5620                5625                5630        
Pro Val Val Phe Lys Glu Arg Ser Asp Ile Cys Lys Ala Ser Ala Phe
        5635                5640                5645            
Gly Lys Asp His Pro Arg Tyr Tyr Ala Thr Tyr Ile Asn Lys Asp Pro
    5650                5655                5660                
Gly Leu Cys Gly His Ser Ser Asp Ile Ser Lys Gln Leu Gly Phe Ser
5665                5670                5675                5680
Gln Ser Gln Arg Tyr Tyr Tyr Tyr Glu
                5685                


<210> 7865
<211> 533
<212> PRT
<213> Homo sapiens

<400> 7865
Met Ile Ser Ser Ser Ser Val His Ser Arg Thr Phe Asn Thr Ser Asn
 1               5                  10                  15      
Ala Leu Gly Pro Val Cys Lys His Lys Lys Pro Leu Ser Ala Ala Lys
            20                  25                  30          
Ala Cys Ile Ser Glu Ile Leu Pro Ser Lys Phe Lys Pro Arg Leu Ser
        35                  40                  45              
Ala Pro Ser Ala Leu Leu Gln Glu Gln Lys Ser Ile Leu Leu Pro Ser
    50                  55                  60                  
Glu Lys Ala Gln Ser Cys Glu Asn Leu Cys Val Ser Gly Ser Leu Asn
65                  70                  75                  80  
Asp Ser Lys Arg Gly Leu Pro Leu Gln Val Gly Gly Ser Ile Glu Asn
                85                  90                  95      
Leu Leu Met Arg Ser Arg Arg Asp Tyr Asp Ser Lys Ser Ser Ser Thr
            100                 105                 110         
Met Ser Leu Gln Glu Tyr Ser Thr Ser Gly Arg Arg Pro Cys Pro Leu
        115                 120                 125             
Ser Arg Lys Ala Gly Met Gln Phe Thr Met Leu Tyr Arg Asp Met His
    130                 135                 140                 
Gln Ile Asn Arg Ser Gly Leu Phe Leu Gly Ser Ile Ser Ser Ser Ser
145                 150                 155                 160 
Ser Val Arg Asp Leu Ala Ser His Phe Glu Lys Ser Ser Leu Ala Leu
                165                 170                 175     
Ser Arg Gly Glu Leu Gly Pro Ser Gln Glu Gly Ser Glu His Ile Pro
            180                 185                 190         
Lys His Thr Val Ser Ser Arg Ile Thr Ala Phe Glu Gln Leu Ile Gln
        195                 200                 205             
Arg Ser Arg Ser Met Pro Ser Leu Asp Leu Ser Gly Arg Leu Ser Lys
    210                 215                 220                 
Ser Pro Thr Pro Val Leu Ser Arg Gly Ser Leu Thr Ser Ala Arg Ser
225                 230                 235                 240 
Ala Glu Ser Leu Leu Glu Ser Thr Lys Leu His Pro Lys Glu Met Asp
                245                 250                 255     
Gly Met Asn Ser Ser Gly Val Tyr Ala Ser Pro Thr Cys Ser Asn Met
            260                 265                 270         
Ala His His Ala Leu Ser Phe Arg Gly Leu Val Pro Ser Glu Pro Leu
        275                 280                 285             
Ser Thr Cys Ser Asp Asp Val Asp Arg Cys Ser Asn Ile Ser Thr Asp
    290                 295                 300                 
Ser Arg Glu Gly Ser Gly Gly Ser Val His Gly Asp Phe Pro Lys His
305                 310                 315                 320 
Arg Leu Asn Lys Cys Lys Gly Thr Cys Pro Ala Ser Tyr Thr Arg Phe
                325                 330                 335     
Thr Thr Ile Arg Lys His Glu Gln Gln Gln Thr Ser Arg Gln Pro Glu
            340                 345                 350         
Trp Arg Leu Asp Ala Arg Gly Asp Lys Ser Thr Leu Leu Arg Asn Ile
        355                 360                 365             
Tyr Leu Met Ser Pro Leu Pro Phe Arg Leu Lys Lys Pro Leu His His
    370                 375                 380                 
His Pro Arg Gln Pro Ser Pro Gly Asp Ser Ser Gly Leu Leu Val Gly
385                 390                 395                 400 
Gln Lys Pro Asp Leu Pro Ser Gln Pro His Gln Asp Gln Pro Pro Ser
                405                 410                 415     
Gly Gly Lys Pro Val Val Pro Thr Arg Leu Ser Ser Arg His Thr Met
            420                 425                 430         
Ala Arg Leu Ser Arg Ser Ser Glu Pro Ser Gln Glu Arg Pro Thr Ala
        435                 440                 445             
Leu Glu Asp Tyr Pro Arg Ala Ile Asn Asn Gly Asn Ser Val Pro Tyr
    450                 455                 460                 
Ser Asp His Ser Leu Asp Arg Asn Asn Asn Pro Gln Ser Glu Leu Ala
465                 470                 475                 480 
Pro Ser Arg Gly Gly Gly Ile Leu Cys Val Cys Leu Val Ser Pro Ala
                485                 490                 495     
Arg Pro Ser Thr Leu Leu Ala Leu Ser Arg Pro Pro Leu Cys Pro Trp
            500                 505                 510         
Cys Ser Phe Ser Gly Leu Ser Phe Val Phe Cys Leu Phe Cys Leu Ala
        515                 520                 525             
Ile Asn His Gly Ser
    530             


<210> 7866
<211> 985
<212> PRT
<213> Homo sapiens

<400> 7866
Met Ser Arg Ile Glu Ser Leu Thr Arg Ala Arg Ile Asp Arg Ser Arg
 1               5                  10                  15      
Glu Leu Ala Ser Lys Thr Arg Glu Lys Glu Lys Met Lys Glu Ala Lys
            20                  25                  30          
Asp Ala Arg Tyr Thr Asn Gly His Leu Phe Thr Thr Ile Ser Val Ser
        35                  40                  45              
Gly Met Thr Met Cys Tyr Ala Cys Asn Lys Ser Ile Thr Ala Lys Glu
    50                  55                  60                  
Ala Leu Ile Cys Pro Thr Cys Asn Val Thr Ile His Asn Arg Cys Lys
65                  70                  75                  80  
Asp Thr Leu Ala Asn Cys Thr Lys Val Lys Gln Lys Gln Gln Lys Ala
                85                  90                  95      
Ala Leu Leu Lys Asn Asn Thr Ala Leu Gln Ser Val Ser Leu Arg Ser
            100                 105                 110         
Lys Thr Thr Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp
        115                 120                 125             
Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu
    130                 135                 140                 
Ser Leu Ala Lys Ser Val Ser Thr Thr Asn Ile Ala Gly His Phe Asn
145                 150                 155                 160 
Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Thr Asp
                165                 170                 175     
Ser Leu Asn Met Arg Asn Arg Thr Leu Ser Val Glu Ser Leu Ile Asp
            180                 185                 190         
Glu Glu Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp Glu
        195                 200                 205             
Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser Phe
    210                 215                 220                 
Leu Gln Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile Tyr
225                 230                 235                 240 
Glu Leu Ile Gln Thr Glu Leu His His Val Arg Thr Leu Lys Ile Met
                245                 250                 255     
Thr Arg Leu Phe Arg Thr Gly Met Leu Glu Glu Leu His Leu Glu Pro
            260                 265                 270         
Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp Ile
        275                 280                 285             
His Thr Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala Leu
    290                 295                 300                 
Cys Pro Gly Ser Thr Arg Asn Phe Val Ile His Arg Leu Gly Asp Leu
305                 310                 315                 320 
Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys Thr
                325                 330                 335     
Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr Lys
            340                 345                 350         
Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys Val
        355                 360                 365             
Thr Arg Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile Leu
    370                 375                 380                 
Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro Leu Leu Ile Ser Arg Ile
385                 390                 395                 400 
Leu Gln His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Thr Thr
                405                 410                 415     
Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly Ile
            420                 425                 430         
Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg Met
        435                 440                 445             
Asp Pro Arg Ala Gln Thr Pro Val Pro Gly Lys Gly Pro Phe Gly Arg
    450                 455                 460                 
Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu Trp
465                 470                 475                 480 
Lys Thr Ala Thr Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met Thr
                485                 490                 495     
Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Pro
            500                 505                 510         
Thr Leu Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val Arg
        515                 520                 525             
Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala Pro
    530                 535                 540                 
Pro Glu Met Tyr Glu Val His Thr Ala Ser Arg Asp Asp Arg Ser Thr
545                 550                 555                 560 
Trp Ile Arg Val Ile Gln Gln Ser Val Arg Thr Cys Pro Ser Arg Glu
                565                 570                 575     
Asp Phe Pro Leu Ile Glu Thr Glu Asp Glu Ala Tyr Leu Arg Arg Ile
            580                 585                 590         
Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu Arg
        595                 600                 605             
Glu Lys Val Gly Leu Phe Ala Glu Met Thr His Phe Gln Ala Glu Glu
    610                 615                 620                 
Asp Gly Gly Ser Gly Met Ala Leu Pro Thr Leu Pro Arg Gly Leu Phe
625                 630                 635                 640 
Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln Asp
                645                 650                 655     
Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro Gly
            660                 665                 670         
Val Glu Leu Leu Leu Thr Pro Arg Glu Pro Ala Leu Pro Leu Glu Pro
        675                 680                 685             
Asp Ser Gly Gly Asn Thr Ser Pro Gly Val Thr Ala Asn Gly Glu Ala
    690                 695                 700                 
Arg Thr Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp Ser
705                 710                 715                 720 
Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu Glu
                725                 730                 735     
Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu Gln
            740                 745                 750         
Ala Ala Val Ala Gln Gln Asp Thr Leu Met Glu Ala Arg Phe Pro Glu
        755                 760                 765             
Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp Gly
    770                 775                 780                 
Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln Ala
785                 790                 795                 800 
Thr Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu Glu
                805                 810                 815     
Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Thr Glu Ala Gly
            820                 825                 830         
Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu Leu
        835                 840                 845             
Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly Gln
    850                 855                 860                 
Thr Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val Asp
865                 870                 875                 880 
Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser Phe
                885                 890                 895     
Asn Pro Pro Gln Pro Ser Arg Gly Thr Asp Arg Leu Asp Leu Pro Val
            900                 905                 910         
Thr Thr Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln Glu
        915                 920                 925             
Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp Thr
    930                 935                 940                 
Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser Pro
945                 950                 955                 960 
Arg Asp Phe Thr Arg Met Gln Asp Ile Pro Glu Glu Thr Glu Ser Arg
                965                 970                 975     
Asp Gly Glu Ala Val Ala Ser Glu Ser
            980                 985 


<210> 7867
<211> 331
<212> PRT
<213> Homo sapiens

<400> 7867
Met Gly Ser Ala Gly Leu Ser Arg Leu His Gly Leu Phe Ala Val Tyr
 1               5                  10                  15      
Lys Pro Pro Gly Leu Lys Trp Lys His Leu Arg Asp Thr Val Glu Leu
            20                  25                  30          
Gln Leu Leu Lys Gly Leu Asn Ala Arg Lys Pro Pro Ala Pro Lys Gln
        35                  40                  45              
Arg Val Arg Phe Leu Leu Gly Pro Met Glu Gly Ser Glu Glu Lys Glu
    50                  55                  60                  
Leu Thr Leu Thr Ala Thr Ser Val Pro Ser Phe Ile Asn His Pro Leu
65                  70                  75                  80  
Val Cys Gly Pro Ala Phe Ala His Leu Lys Val Gly Val Gly His Arg
                85                  90                  95      
Leu Asp Ala Gln Ala Ser Gly Val Leu Val Leu Gly Val Gly His Gly
            100                 105                 110         
Cys Arg Leu Leu Thr Asp Met Tyr Asn Ala His Leu Thr Lys Asp Tyr
        115                 120                 125             
Thr Val Arg Gly Leu Leu Gly Lys Ala Thr Asp Asp Phe Arg Glu Asp
    130                 135                 140                 
Gly Arg Leu Val Glu Lys Thr Thr Tyr Asp His Val Thr Arg Glu Lys
145                 150                 155                 160 
Leu Asp Arg Ile Leu Ala Val Ile Gln Gly Ser His Gln Lys Ala Leu
                165                 170                 175     
Val Met Tyr Ser Asn Leu Asp Leu Lys Thr Gln Glu Ala Tyr Glu Met
            180                 185                 190         
Ala Val Arg Gly Leu Ile Arg Pro Met Asn Lys Ser Pro Met Leu Ile
        195                 200                 205             
Thr Gly Ile Arg Cys Leu Tyr Phe Ala Pro Pro Glu Phe Leu Leu Glu
    210                 215                 220                 
Val Gln Cys Met His Glu Thr Gln Lys Glu Leu Arg Lys Leu Val His
225                 230                 235                 240 
Glu Ile Gly Leu Glu Leu Lys Thr Thr Ala Val Cys Thr Gln Val Arg
                245                 250                 255     
Arg Thr Arg Asp Gly Phe Phe Thr Leu Asp Ser Ala Leu Leu Arg Thr
            260                 265                 270         
Gln Trp Asp Leu Thr Asn Ile Gln Asp Ala Ile Arg Ala Ala Thr Pro
        275                 280                 285             
Gln Val Ala Ala Glu Leu Glu Lys Ser Leu Ser Pro Gly Leu Asp Thr
    290                 295                 300                 
Lys Gln Leu Pro Ser Pro Gly Trp Ser Trp Asp Ser Gln Gly Pro Ser
305                 310                 315                 320 
Ser Thr Leu Gly Leu Glu Arg Gly Ala Gly Gln
                325                 330     


<210> 7868
<211> 245
<212> PRT
<213> Homo sapiens

<400> 7868
Met Thr Ser Ser Tyr Gly His Val Leu Glu Arg Gln Pro Ala Leu Gly
 1               5                  10                  15      
Gly Arg Leu Asp Ser Pro Gly Asn Leu Asp Thr Leu Gln Ala Lys Lys
            20                  25                  30          
Asn Phe Ser Val Ser His Leu Leu Asp Leu Glu Glu Ala Gly Asp Met
        35                  40                  45              
Val Ala Ala Gln Ala Asp Glu Asn Val Gly Glu Ala Gly Arg Ser Leu
    50                  55                  60                  
Leu Glu Ser Pro Gly Leu Thr Ser Gly Ser Asp Thr Pro Gln Gln Asp
65                  70                  75                  80  
Asn Asp Gln Leu Asn Ser Glu Glu Lys Lys Lys Arg Lys Gln Arg Arg
                85                  90                  95      
Asn Arg Thr Thr Phe Asn Ser Ser Gln Leu Gln Ala Leu Glu Arg Val
            100                 105                 110         
Phe Glu Arg Thr His Tyr Pro Asp Ala Phe Val Arg Glu Asp Leu Ala
        115                 120                 125             
Arg Arg Val Asn Leu Thr Glu Ala Arg Val Gln Val Trp Phe Gln Asn
    130                 135                 140                 
Arg Arg Ala Lys Phe Arg Arg Asn Glu Arg Ala Met Leu Ala Asn Lys
145                 150                 155                 160 
Asn Ala Ser Leu Leu Lys Ser Tyr Ser Gly Asp Val Thr Ala Val Glu
                165                 170                 175     
Gln Pro Ile Val Pro Arg Pro Ala Pro Arg Pro Thr Asp Tyr Leu Ser
            180                 185                 190         
Trp Gly Thr Ala Ser Pro Tyr Ser Ala Met Ala Thr Tyr Ser Ala Thr
        195                 200                 205             
Cys Ala Asn Asn Ser Pro Ala Gln Gly Ile Asn Met Ala Asn Ser Ile
    210                 215                 220                 
Ala Asn Leu Arg Leu Lys Ala Lys Glu Tyr Ser Leu Gln Arg Asn Gln
225                 230                 235                 240 
Val Pro Thr Val Asn
                245 


<210> 7869
<211> 113
<212> PRT
<213> Homo sapiens

<400> 7869
Met Ala Thr Arg Thr Leu Asn Leu Ser Phe Phe Pro Arg Ser His Trp
 1               5                  10                  15      
Pro Pro Gly Thr Cys Ser Leu Ala Thr Ala Ile Met Lys Asp Leu Thr
            20                  25                  30          
Gly Leu Ser Thr Cys Ala Gln Ala Thr Gln Val Glu Val Glu Gly Met
        35                  40                  45              
Gly Phe Lys Pro Arg Pro Ser Leu Ala Leu Asn Ile Tyr Leu Lys Gln
    50                  55                  60                  
Pro Pro Tyr Gln Glu Gly Gly Cys Pro Ala Trp Ser Glu Glu Cys Met
65                  70                  75                  80  
Glu Gln Ser Gln Pro Thr Gln Val Gly Cys Val Thr Trp Pro Arg Asn
                85                  90                  95      
Pro Pro Met Leu Leu Arg Ala Thr Ala Pro Trp Gly His Val Ser Pro
            100                 105                 110         
Asn
    


<210> 7870
<211> 343
<212> PRT
<213> Homo sapiens

<400> 7870
Asn Ala Gly Glu Val Gly Ala Asp His Ile Asn Ile Leu Ala Leu Gly
 1               5                  10                  15      
Trp Val Gly Val Glu Pro Gln Lys Cys Ser Gln Ala His Ser Tyr Gln
            20                  25                  30          
Glu Pro Met Ser Lys Ile Arg Gly Leu Pro Pro Glu Val Arg Glu Pro
        35                  40                  45              
Gly Pro Gly Val Glu Leu Gly Val Glu Asn Gly Leu Leu Cys Gln Leu
    50                  55                  60                  
Ile His Ser Pro Glu Phe Asn Leu Phe Ser Asn Ser Val Val Phe Glu
65                  70                  75                  80  
Ser Asn Phe Ile Gln Thr His Val Pro Glu Ala Asp Phe Gln Val Thr
                85                  90                  95      
Lys Pro Gly Asn Trp Arg Asp Val Cys Glu Gly Ser Ala Thr Val Ile
            100                 105                 110         
Leu Gly Val Thr Ser Ser Val Pro Ser Leu Pro Leu Pro Asn Val Leu
        115                 120                 125             
Leu Met Ala Asn Val Thr Trp Pro Gln Gly Pro Phe Thr Thr Trp Ser
    130                 135                 140                 
Thr Thr Gly Asp Ala Pro Val Ile Asn Leu Ser Arg Leu Leu Pro Leu
145                 150                 155                 160 
Lys Tyr Val Glu Leu Arg Ile Tyr Asp Trp Leu Gln Arg Ile Leu Arg
                165                 170                 175     
Val Arg Thr Val Thr Glu Lys Ile Tyr Tyr Leu Lys Leu His Glu Lys
            180                 185                 190         
His Pro Glu Ile Val Phe Gln Phe Trp Val Arg Leu Val Lys Ile Leu
        195                 200                 205             
Gln Lys Gly Leu Ser Ile Thr Thr Lys Asp Pro Arg Ile Lys Phe Thr
    210                 215                 220                 
His Cys Leu Val Pro Lys Met Pro Thr Asn Ser Thr Glu Thr Thr Pro
225                 230                 235                 240 
Glu Asn Ser Leu Leu Ser Ser Pro Gln Pro Ser Glu Pro Leu Val Leu
                245                 250                 255     
Leu Ala Ala Glu Gln Thr Ser Gly Ser Phe Ser Gln Leu Ser Gly Lys
            260                 265                 270         
Pro Gln Leu Thr Ala Asp Arg Asn Asn Asp Thr Ala Val Glu Ile Asp
        275                 280                 285             
Asn Cys Ser Ser Tyr Lys Ile Pro Ser Pro Val Ala Ser Pro Ile Asn
    290                 295                 300                 
Leu Asn Ile Pro Met Arg Ala Ala Leu Ser His Ser Leu Trp Glu Gln
305                 310                 315                 320 
Glu Asp Trp Asn Glu His Leu Leu Gln Val His Ile Ala Ser Tyr Leu
                325                 330                 335     
Gly Glu His Phe Leu Gly Ala
            340             


<210> 7871
<211> 165
<212> PRT
<213> Homo sapiens

<400> 7871
Met Pro Ile Glu Glu Glu Ile Leu Thr Gly Gln Arg Met Ser Thr Gly
 1               5                  10                  15      
His Ser Asn Thr Asn Arg Thr Asp Asp Ala Asn Arg Thr Glu Asn Thr
            20                  25                  30          
Lys Arg Thr Gly Asp Val Lys Arg Ile Glu Asn Thr Asn Arg Thr Gly
        35                  40                  45              
Asp Ala Asn Arg Thr Glu Ser Thr Asn Arg Arg Gly Asp Val Asn Arg
    50                  55                  60                  
Thr Glu Asn Thr Asn Arg Thr Gly Asn Thr Asn Arg Thr Gly Asp Val
65                  70                  75                  80  
Asn Arg Thr Glu Asn Arg Ala Gly Met Ala Asn Arg Thr Asp Asn Thr
                85                  90                  95      
Asn Arg Thr Gly Asp Ala Thr Val Ile Lys Gln Glu Met Leu Thr Gly
            100                 105                 110         
Gln Glu Met Pro Arg Glu Gln Glu Ile Thr Ser Arg Thr Val Asn Thr
        115                 120                 125             
Asn Arg Thr Glu Phe Val Asn Gly Thr Gly Ser Thr Asn Arg Ile Gly
    130                 135                 140                 
Asp Ile Ala Leu Asn Asn Arg Val Ser Ser Leu Thr Val Ser Asn Ala
145                 150                 155                 160 
Ile Gln Met Arg Ser
                165 


<210> 7872
<211> 431
<212> PRT
<213> Homo sapiens

<400> 7872
Met Ser Asp Tyr Trp Val Val Gly Lys Lys Ser Asn Tyr Glu Val Leu
 1               5                  10                  15      
Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro Lys Ser Leu Leu Asp
            20                  25                  30          
Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile Gln Gln Thr Phe Arg
        35                  40                  45              
Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile Leu Lys Phe Phe Glu
    50                  55                  60                  
Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu Cys Phe Lys Cys Ala
65                  70                  75                  80  
Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu Ala Ile Gly Pro Glu
                85                  90                  95      
Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys Asn Pro Thr His Leu
            100                 105                 110         
Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr Ser Asn Ser Glu Asp
        115                 120                 125             
Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile Ala Gly Ala Pro Glu
    130                 135                 140                 
Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile Ala Glu Asn Met Ala
145                 150                 155                 160 
Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn Gly Thr Ser Gln Ser
                165                 170                 175     
Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg Ala Leu Pro Ser Ile
            180                 185                 190         
Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met Arg Thr His Ala Val
        195                 200                 205             
Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile Ile Asp Glu Glu Asp
    210                 215                 220                 
Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu Ile Gln Arg Glu Arg
225                 230                 235                 240 
Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln Phe Gly Asp Val His
                245                 250                 255     
Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala Leu Ala Val Ala Ile
            260                 265                 270         
Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val Arg Glu Lys Phe Leu
        275                 280                 285             
Gln Glu Ala Cys His Tyr Thr Ser Leu His Trp Asn Trp Cys Arg Tyr
    290                 295                 300                 
Ile Ser Asp Pro Asn Val Asp Ala Cys Pro Asp Pro Arg Asn Ala Glu
305                 310                 315                 320 
Leu Thr Met Arg Gln Phe Asp His Pro His Ile Val Lys Leu Ile Gly
                325                 330                 335     
Val Ile Thr Glu Asn Pro Val Trp Ile Ile Met Glu Leu Cys Thr Leu
            340                 345                 350         
Gly Glu Leu Arg Ser Phe Leu Gln Val Arg Lys Tyr Ser Leu Asp Leu
        355                 360                 365             
Ala Ser Leu Ile Leu Tyr Ala Tyr Gln Leu Ser Thr Ala Leu Ala Tyr
    370                 375                 380                 
Leu Glu Ser Lys Arg Phe Val His Arg Asp Ile Ala Ala Arg Asn Val
385                 390                 395                 400 
Leu Val Ser Ser Asn Asp Cys Val Lys Leu Gly Asp Phe Gly Leu Ser
                405                 410                 415     
Arg Tyr Met Glu Asp Ser Thr Tyr Tyr Lys Gly Lys Lys Ser Gly
            420                 425                 430     


<210> 7873
<211> 1006
<212> PRT
<213> Homo sapiens

<400> 7873
Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Asn Ser
 1               5                  10                  15      
Ser Thr Lys Thr His Leu Gly Thr Gly Met Glu Arg Ser Pro Gly Ala
            20                  25                  30          
Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Asn Ser Glu
        35                  40                  45              
Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val
    50                  55                  60                  
Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val
65                  70                  75                  80  
Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His
                85                  90                  95      
Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu
            100                 105                 110         
Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr
        115                 120                 125             
Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu
    130                 135                 140                 
Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala
145                 150                 155                 160 
Asp Gln Val Asp Gln Glu Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile
                165                 170                 175     
Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser
            180                 185                 190         
Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro
        195                 200                 205             
Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile
    210                 215                 220                 
Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile
225                 230                 235                 240 
Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu
                245                 250                 255     
Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu
            260                 265                 270         
Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys
        275                 280                 285             
Asn Pro Thr His Leu Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr
    290                 295                 300                 
Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile
305                 310                 315                 320 
Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile
                325                 330                 335     
Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn
            340                 345                 350         
Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg
        355                 360                 365             
Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met
    370                 375                 380                 
Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile
385                 390                 395                 400 
Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu
                405                 410                 415     
Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln
            420                 425                 430         
Phe Gly Asp Val His Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala
        435                 440                 445             
Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val
    450                 455                 460                 
Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His
465                 470                 475                 480 
Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp
                485                 490                 495     
Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln
            500                 505                 510         
Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr
        515                 520                 525             
Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His
    530                 535                 540                 
Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val
545                 550                 555                 560 
Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr
                565                 570                 575     
Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu
            580                 585                 590         
Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe
        595                 600                 605             
Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln
    610                 615                 620                 
Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg
625                 630                 635                 640 
Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr
                645                 650                 655     
Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu
            660                 665                 670         
Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Ala Gln Gln Glu
        675                 680                 685             
Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp
    690                 695                 700                 
Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr
705                 710                 715                 720 
Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met
                725                 730                 735     
Val Gln Thr Asn His Tyr Gln Asp Ser Thr Val Leu Asp Leu Arg Gly
            740                 745                 750         
Ile Gly Gln Val Leu Pro Thr His Leu Met Glu Glu Arg Leu Ile Arg
        755                 760                 765             
Gln Gln Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu
    770                 775                 780                 
Arg Phe Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg
785                 790                 795                 800 
Glu Asp Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln His Ile Tyr Gln
                805                 810                 815     
Pro Val Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg
            820                 825                 830         
Pro Gly Ala Pro Gly His Leu Gly Ser Leu Ala Ser Leu Ser Ser Pro
        835                 840                 845             
Ala Asp Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro Gln Glu Ile Ser
    850                 855                 860                 
Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr Glu
865                 870                 875                 880 
Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys Ile
                885                 890                 895     
Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val Gly
            900                 905                 910         
Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro Leu
        915                 920                 925             
Leu Pro Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu Leu
    930                 935                 940                 
Asn Ser Asp Leu Gly Glu Leu Ile Asn Lys Met Lys Leu Ala Gln Gln
945                 950                 955                 960 
Tyr Val Met Thr Ser Leu Gln Gln Glu Tyr Lys Lys Gln Met Leu Thr
                965                 970                 975     
Ala Ala His Ala Leu Ala Val Asp Ala Lys Asn Leu Leu Asp Val Ile
            980                 985                 990         
Asp Gln Ala Arg Leu Lys Met Leu Gly Gln Thr Arg Pro His
        995                 1000                1005    


<210> 7874
<211> 554
<212> PRT
<213> Homo sapiens

<400> 7874
Met Ser Asp Tyr Trp Val Val Gly Lys Lys Ser Asn Tyr Glu Val Leu
 1               5                  10                  15      
Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro Lys Ser Leu Leu Asp
            20                  25                  30          
Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile Gln Gln Thr Phe Arg
        35                  40                  45              
Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile Leu Lys Phe Phe Glu
    50                  55                  60                  
Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu Cys Phe Lys Cys Ala
65                  70                  75                  80  
Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu Ala Ile Gly Pro Glu
                85                  90                  95      
Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys Asn Pro Thr His Leu
            100                 105                 110         
Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr Ser Asn Ser Glu Asp
        115                 120                 125             
Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile Ala Gly Ala Pro Glu
    130                 135                 140                 
Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile Ala Glu Asn Met Ala
145                 150                 155                 160 
Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn Gly Thr Ser Gln Ser
                165                 170                 175     
Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg Ala Leu Pro Ser Ile
            180                 185                 190         
Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met Arg Thr His Ala Val
        195                 200                 205             
Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile Ile Asp Glu Glu Asp
    210                 215                 220                 
Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu Ile Gln Arg Glu Arg
225                 230                 235                 240 
Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln Phe Gly Asp Val His
                245                 250                 255     
Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala Leu Ala Val Ala Ile
            260                 265                 270         
Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val Arg Glu Lys Phe Leu
        275                 280                 285             
Gln Glu Ala Cys His Tyr Thr Ser Leu His Trp Asn Trp Cys Arg Tyr
    290                 295                 300                 
Ile Ser Asp Pro Asn Val Asp Ala Cys Pro Asp Pro Arg Asn Ala Glu
305                 310                 315                 320 
Leu Thr Met Arg Gln Phe Asp His Pro His Ile Val Lys Leu Ile Gly
                325                 330                 335     
Val Ile Thr Glu Asn Pro Val Trp Ile Ile Met Glu Leu Cys Thr Leu
            340                 345                 350         
Gly Glu Leu Arg Ser Phe Leu Gln Val Arg Lys Tyr Ser Leu Asp Leu
        355                 360                 365             
Ala Ser Leu Ile Leu Tyr Ala Tyr Gln Leu Ser Thr Ala Leu Ala Tyr
    370                 375                 380                 
Leu Glu Ser Lys Arg Phe Val His Arg Asp Ile Ala Ala Arg Asn Val
385                 390                 395                 400 
Leu Val Ser Ser Asn Asp Cys Val Lys Leu Gly Asp Phe Gly Leu Ser
                405                 410                 415     
Arg Tyr Met Glu Asp Ser Thr Tyr Tyr Lys Ala Ser Lys Gly Lys Leu
            420                 425                 430         
Pro Ile Lys Trp Met Ala Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr
        435                 440                 445             
Ser Ala Ser Asp Val Trp Met Phe Gly Val Cys Met Trp Glu Ile Leu
    450                 455                 460                 
Met His Gly Val Lys Pro Phe Gln Gly Val Lys Asn Asn Asp Val Ile
465                 470                 475                 480 
Gly Arg Ile Glu Asn Gly Glu Arg Leu Pro Met Pro Pro Asn Cys Pro
                485                 490                 495     
Pro Thr Leu Tyr Ser Leu Met Thr Lys Cys Trp Ala Tyr Asp Pro Ser
            500                 505                 510         
Arg Arg Pro Arg Phe Thr Glu Leu Lys Ala Gln Leu Phe Gln Asn Pro
        515                 520                 525             
Ala Gln Met Leu Pro Ala Ser Gly Arg Leu Pro Asn Gln Pro Cys Pro
    530                 535                 540                 
Glu Arg Glu Asn Tyr Ser Phe Ala Thr Phe
545                 550                 


<210> 7875
<211> 1074
<212> PRT
<213> Homo sapiens

<400> 7875
Met Ile Ser Ala Asp Cys Asn Leu Cys Leu Pro Glu Tyr Asp Arg Tyr
 1               5                  10                  15      
Leu Ala Ser Ser Lys Ile Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu
            20                  25                  30          
Asn His Thr Pro Asn Ser Ser Thr Lys Thr His Leu Gly Thr Gly Met
        35                  40                  45              
Glu Arg Ser Pro Gly Ala Met Glu Arg Val Leu Lys Val Phe His Tyr
    50                  55                  60                  
Phe Glu Ser Asn Ser Glu Pro Thr Thr Trp Ala Ser Ile Ile Arg His
65                  70                  75                  80  
Gly Asp Ala Thr Asp Val Arg Gly Ile Ile Gln Lys Ile Val Asp Ser
                85                  90                  95      
His Lys Val Lys His Val Ala Cys Tyr Gly Phe Arg Leu Ser His Leu
            100                 105                 110         
Arg Ser Glu Glu Val His Trp Leu His Val Asp Met Gly Val Ser Ser
        115                 120                 125             
Val Arg Glu Lys Tyr Glu Leu Ala His Pro Pro Glu Glu Trp Lys Tyr
    130                 135                 140                 
Glu Leu Arg Ile Arg Tyr Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr
145                 150                 155                 160 
Glu Asp Lys Pro Thr Leu Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp
                165                 170                 175     
Tyr Met Leu Glu Ile Ala Asp Gln Val Asp Gln Glu Ile Ala Leu Lys
            180                 185                 190         
Leu Gly Cys Leu Glu Ile Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn
        195                 200                 205             
Ala Leu Glu Lys Lys Ser Asn Tyr Glu Val Leu Glu Lys Asp Val Gly
    210                 215                 220                 
Leu Lys Arg Phe Phe Pro Lys Ser Leu Leu Asp Ser Val Lys Ala Lys
225                 230                 235                 240 
Thr Leu Arg Lys Leu Ile Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu
                245                 250                 255     
Asn Arg Glu Glu Ser Ile Leu Lys Phe Phe Glu Ile Leu Ser Pro Val
            260                 265                 270         
Tyr Arg Phe Asp Lys Glu Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp
        275                 280                 285             
Ile Ile Ser Val Glu Leu Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr
    290                 295                 300                 
Leu Thr Asp Lys Gly Cys Asn Pro Thr His Leu Ala Asp Phe Thr Gln
305                 310                 315                 320 
Val Gln Thr Ile Gln Tyr Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly
                325                 330                 335     
Met Leu Gln Leu Lys Ile Ala Gly Ala Pro Glu Pro Leu Thr Val Thr
            340                 345                 350         
Ala Pro Ser Leu Thr Ile Ala Glu Asn Met Ala Asp Leu Ile Asp Gly
        355                 360                 365             
Tyr Cys Arg Leu Val Asn Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro
    370                 375                 380                 
Gln Lys Glu Gly Glu Arg Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn
385                 390                 395                 400 
Ser Glu Lys Gln Gly Met Arg Thr His Ala Val Ser Val Ser Glu Thr
                405                 410                 415     
Asp Asp Tyr Ala Glu Ile Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro
            420                 425                 430         
Ser Thr Arg Asp Tyr Glu Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg
        435                 440                 445             
Cys Ile Gly Glu Gly Gln Phe Gly Asp Val His Gln Gly Ile Tyr Met
    450                 455                 460                 
Ser Pro Glu Asn Pro Ala Leu Ala Val Ala Ile Lys Thr Cys Lys Asn
465                 470                 475                 480 
Cys Thr Ser Asp Ser Val Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr
                485                 490                 495     
Met Arg Gln Phe Asp His Pro His Ile Val Lys Leu Ile Gly Val Ile
            500                 505                 510         
Thr Glu Asn Pro Val Trp Ile Ile Met Glu Leu Cys Thr Leu Gly Glu
        515                 520                 525             
Leu Arg Ser Phe Leu Gln Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser
    530                 535                 540                 
Leu Ile Leu Tyr Ala Tyr Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu
545                 550                 555                 560 
Ser Lys Arg Phe Val His Arg Asp Ile Ala Ala Arg Asn Val Leu Val
                565                 570                 575     
Ser Ser Asn Asp Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr
            580                 585                 590         
Met Glu Asp Ser Thr Tyr Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile
        595                 600                 605             
Lys Trp Met Ala Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala
    610                 615                 620                 
Ser Asp Val Trp Met Phe Gly Val Cys Met Trp Glu Ile Leu Met His
625                 630                 635                 640 
Gly Val Lys Pro Phe Gln Gly Val Lys Asn Asn Asp Val Ile Gly Arg
                645                 650                 655     
Ile Glu Asn Gly Glu Arg Leu Pro Met Pro Pro Asn Cys Pro Pro Thr
            660                 665                 670         
Leu Tyr Ser Leu Met Thr Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg
        675                 680                 685             
Pro Arg Phe Thr Glu Leu Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu
    690                 695                 700                 
Glu Lys Ala Gln Gln Glu Glu Arg Met Arg Met Glu Ser Arg Arg Gln
705                 710                 715                 720 
Ala Thr Val Ser Trp Asp Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys
                725                 730                 735     
Pro Ser Arg Pro Gly Tyr Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr
            740                 745                 750         
Pro Ser Pro Gln His Met Val Gln Thr Asn His Tyr Gln Val Ser Gly
        755                 760                 765             
Tyr Pro Gly Ser His Gly Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro
    770                 775                 780                 
Gly Gln Ala Ser Leu Leu Asp Gln Thr Asp Ser Trp Asn His Arg Pro
785                 790                 795                 800 
Gln Glu Ile Ala Met Trp Gln Pro Asn Val Glu Asp Ser Thr Val Leu
                805                 810                 815     
Asp Leu Arg Gly Ile Gly Gln Val Leu Pro Thr His Leu Met Glu Glu
            820                 825                 830         
Arg Leu Ile Arg Gln Gln Gln Glu Met Glu Glu Asp Gln Arg Trp Leu
        835                 840                 845             
Glu Lys Glu Glu Arg Phe Leu Lys Pro Asp Val Arg Leu Ser Arg Gly
    850                 855                 860                 
Ser Ile Asp Arg Glu Asp Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln
865                 870                 875                 880 
His Ile Tyr Gln Pro Val Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys
                885                 890                 895     
Lys Pro Pro Arg Pro Gly Ala Pro Gly His Leu Gly Ser Leu Ala Ser
            900                 905                 910         
Leu Ser Ser Pro Ala Asp Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro
        915                 920                 925             
Gln Glu Ile Ser Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp
    930                 935                 940                 
Lys Val Tyr Glu Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met
945                 950                 955                 960 
Ser Ser Lys Ile Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val
                965                 970                 975     
Lys Glu Val Gly Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu
            980                 985                 990         
Thr Ile Pro Leu Leu Pro Ala Ser Thr His Arg Glu Ile Glu Met Ala
        995                 1000                1005            
Gln Lys Leu Leu Asn Ser Asp Leu Gly Glu Leu Ile Asn Lys Met Lys
    1010                1015                1020                
Leu Ala Gln Gln Tyr Val Met Thr Ser Leu Gln Gln Glu Tyr Lys Lys
1025                1030                1035                1040
Gln Met Leu Thr Ala Ala His Ala Leu Ala Val Asp Ala Lys Asn Leu
                1045                1050                1055    
Leu Asp Val Ile Asp Gln Ala Arg Leu Lys Met Leu Gly Gln Thr Arg
            1060                1065                1070        
Pro His
        


<210> 7876
<211> 1052
<212> PRT
<213> Homo sapiens

<400> 7876
Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Asn Ser
 1               5                  10                  15      
Ser Thr Lys Thr His Leu Gly Thr Gly Met Glu Arg Ser Pro Gly Ala
            20                  25                  30          
Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Asn Ser Glu
        35                  40                  45              
Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val
    50                  55                  60                  
Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val
65                  70                  75                  80  
Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His
                85                  90                  95      
Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu
            100                 105                 110         
Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr
        115                 120                 125             
Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu
    130                 135                 140                 
Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala
145                 150                 155                 160 
Asp Gln Val Asp Gln Glu Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile
                165                 170                 175     
Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser
            180                 185                 190         
Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro
        195                 200                 205             
Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile
    210                 215                 220                 
Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile
225                 230                 235                 240 
Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu
                245                 250                 255     
Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu
            260                 265                 270         
Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys
        275                 280                 285             
Asn Pro Thr His Leu Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr
    290                 295                 300                 
Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile
305                 310                 315                 320 
Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile
                325                 330                 335     
Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn
            340                 345                 350         
Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg
        355                 360                 365             
Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met
    370                 375                 380                 
Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile
385                 390                 395                 400 
Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu
                405                 410                 415     
Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln
            420                 425                 430         
Phe Gly Asp Val His Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala
        435                 440                 445             
Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val
    450                 455                 460                 
Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His
465                 470                 475                 480 
Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp
                485                 490                 495     
Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln
            500                 505                 510         
Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr
        515                 520                 525             
Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His
    530                 535                 540                 
Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val
545                 550                 555                 560 
Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr
                565                 570                 575     
Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu
            580                 585                 590         
Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe
        595                 600                 605             
Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln
    610                 615                 620                 
Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg
625                 630                 635                 640 
Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr
                645                 650                 655     
Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu
            660                 665                 670         
Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Ala Gln Gln Glu
        675                 680                 685             
Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp
    690                 695                 700                 
Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr
705                 710                 715                 720 
Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met
                725                 730                 735     
Val Gln Thr Asn His Tyr Gln Val Ser Gly Tyr Pro Gly Ser His Gly
            740                 745                 750         
Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro Gly Gln Ala Ser Leu Leu
        755                 760                 765             
Asp Gln Thr Asp Ser Trp Asn His Arg Pro Gln Glu Ile Ala Met Trp
    770                 775                 780                 
Gln Pro Asn Val Glu Asp Ser Thr Val Leu Asp Leu Arg Gly Ile Gly
785                 790                 795                 800 
Gln Val Leu Pro Thr His Leu Met Glu Glu Arg Leu Ile Arg Gln Gln
                805                 810                 815     
Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu Arg Phe
            820                 825                 830         
Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg Glu Asp
        835                 840                 845             
Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln His Ile Tyr Gln Pro Val
    850                 855                 860                 
Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg Pro Gly
865                 870                 875                 880 
Ala Pro Gly His Leu Gly Ser Leu Ala Ser Leu Ser Ser Pro Ala Asp
                885                 890                 895     
Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro Gln Glu Ile Ser Pro Pro
            900                 905                 910         
Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr Glu Asn Val
        915                 920                 925             
Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys Ile Gln Pro
    930                 935                 940                 
Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val Gly Leu Ala
945                 950                 955                 960 
Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro Leu Leu Pro
                965                 970                 975     
Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu Leu Asn Ser
            980                 985                 990         
Asp Leu Gly Glu Leu Ile Asn Lys Met Lys Leu Ala Gln Gln Tyr Val
        995                 1000                1005            
Met Thr Ser Leu Gln Gln Glu Tyr Lys Lys Gln Met Leu Thr Ala Ala
    1010                1015                1020                
His Ala Leu Ala Val Asp Ala Lys Asn Leu Leu Asp Val Ile Asp Gln
1025                1030                1035                1040
Ala Arg Leu Lys Met Leu Gly Gln Thr Arg Pro His
                1045                1050        


<210> 7877
<211> 235
<212> PRT
<213> Homo sapiens

<400> 7877
Met Ala Ala Ala Asn Pro Trp Asp Pro Ala Ser Ala Pro Asn Gly Ala
 1               5                  10                  15      
Gly Leu Val Leu Gly His Phe Ile Ala Ser Gly Met Val Asn Gln Glu
            20                  25                  30          
Met Leu Asn Met Ser Lys Lys Thr Val Ser Cys Phe Val Asn Phe Thr
        35                  40                  45              
Arg Leu Gln Gln Ile Thr Asn Ile Gln Ala Glu Ile Tyr Gln Lys Asn
    50                  55                  60                  
Leu Glu Ile Glu Leu Leu Lys Leu Glu Lys Asp Thr Ala Asp Val Val
65                  70                  75                  80  
His Pro Phe Phe Leu Ala Gln Lys Cys His Thr Leu Gln Ser Met Asn
                85                  90                  95      
Asn His Leu Glu Ala Val Leu Lys Glu Lys Arg Ser Leu Arg Gln Arg
            100                 105                 110         
Leu Leu Lys Pro Met Cys Gln Glu Asn Leu Pro Ile Glu Ala Val Tyr
        115                 120                 125             
His Arg Tyr Met Val His Leu Leu Glu Leu Ala Val Thr Phe Ile Glu
    130                 135                 140                 
Arg Leu Glu Thr His Leu Glu Thr Ile Arg Asn Ile Pro His Leu Ala
145                 150                 155                 160 
Ala Asn Leu Lys Lys Met Asn Gln Ala Leu Ala Lys Met Asp Ile Leu
                165                 170                 175     
Val Thr Glu Thr Glu Glu Leu Ala Glu Asn Ile Leu Lys Trp Arg Lys
            180                 185                 190         
Gln Gln Asn Glu Val Ser Ser Cys Ile Pro Lys Ile Leu Ala Glu Glu
        195                 200                 205             
Ser Tyr Leu Tyr Lys His Asp Ile Ile Met Pro Pro Leu Pro Phe Thr
    210                 215                 220                 
Ser Lys Val His Val Gln Thr Ile Asn Ala Lys
225                 230                 235 


<210> 7878
<211> 361
<212> PRT
<213> Homo sapiens

<400> 7878
Met Ser Ala Asp Ala Thr Pro Leu His Val Ala Arg Ser Gly Asn Asp
 1               5                  10                  15      
Thr Glu Asp Phe Ser Asn Pro Ser Ala Cys Ser Asp Ile Tyr Gly Glu
            20                  25                  30          
Ser Ile Ser Ser His Phe Thr Glu Ser Thr Gly Lys Leu Ile Glu Ser
        35                  40                  45              
Leu Ser Asp Cys Ala Ser Ser Leu Pro Ile Lys Lys Ile Ala Gly Ser
    50                  55                  60                  
Asn Tyr Asn Thr Phe Leu Asp Ser Glu Leu Ser Met Leu Asn Gly Thr
65                  70                  75                  80  
Lys Val Leu Ser Asp Ser Ala Val Gly Ile Asp Leu Gly Ser Thr Gly
                85                  90                  95      
Asp Thr Thr Glu Ala Leu His Glu Leu Arg Thr Ala Glu Glu Phe Lys
            100                 105                 110         
Thr Glu Glu Gln Asp Asp Ser Gly Ser Ile Glu Phe Gly Val Ser Phe
        115                 120                 125             
Pro Asp Arg Glu Ser Ser Ser Met Glu Thr Ser Ile Glu Pro Lys Ala
    130                 135                 140                 
Thr Glu Thr Ser Arg Thr Glu Gly Ile Thr Ala Ile Glu Glu Ser Trp
145                 150                 155                 160 
Glu Ser Met Phe Asn Asp Asp Gly Asp Cys Leu Asp Pro Arg Leu Leu
                165                 170                 175     
Gln Glu Leu Ser Gly Asn Thr Lys Ser Arg Glu Ser Ile Gln Glu Pro
            180                 185                 190         
Arg Ser Asp Tyr Tyr Asn His Glu Val Pro Asp Ile Asp Leu Ser Asp
        195                 200                 205             
Cys Glu Phe Pro His Val Ile Glu Ile Tyr Asp Phe Pro Gln Glu Phe
    210                 215                 220                 
Arg Thr Glu Asp Leu Leu Arg Val Phe Cys Ser Tyr Gln Lys Lys Gly
225                 230                 235                 240 
Phe Asp Ile Lys Trp Val Asp Asp Thr His Ala Leu Gly Val Phe Ser
                245                 250                 255     
Ser Pro Ile Thr Ala Arg Asp Ala Leu Gly Ile Lys His Thr Met Val
            260                 265                 270         
Lys Ile Arg Pro Leu Ser Gln Ala Thr Arg Ala Ala Lys Ala Lys Ala
        275                 280                 285             
Arg Ala Tyr Ala Glu Phe Leu Gln Pro Ala Lys Glu Arg Pro Glu Thr
    290                 295                 300                 
Ser Ala Ala Leu Ala Arg Arg Leu Val Ile Ser Ala Leu Gly Val Arg
305                 310                 315                 320 
Ser Lys Gln Ser Lys Thr Glu Arg Glu Ala Glu Leu Lys Lys Leu Gln
                325                 330                 335     
Glu Ala Arg Glu Arg Lys Arg Leu Glu Ala Lys Gln Arg Glu Asp Ile
            340                 345                 350         
Trp Glu Gly Arg Asp Gln Ser Thr Val
        355                 360     


<210> 7879
<211> 792
<212> PRT
<213> Homo sapiens

<400> 7879
Met Gln Gln Glu Ser Glu Arg Cys Arg Val Arg Ala Arg Arg Pro Asp
 1               5                  10                  15      
Met Ala Leu Tyr Val Pro Lys Ala Arg Arg Gly Ala Val Leu Leu Lys
            20                  25                  30          
Thr Gly Asp Glu Glu Glu Ser Cys Gly Ser Pro Asn Ser Val Val Lys
        35                  40                  45              
Glu Lys Gln Lys Glu Ser Ser Leu Ser Gln Lys Glu Val Phe Lys Asp
    50                  55                  60                  
Lys Pro Glu Ala Arg Arg Leu Asn Ile Asn Pro Asp Arg Lys Glu His
65                  70                  75                  80  
Asn Cys Arg Glu Glu Lys Lys Ser Ser Thr Lys Leu Arg Met Asp Thr
                85                  90                  95      
Cys Leu Gln Lys Thr Asn Arg Val Cys Ser Lys Arg Gly Thr Thr Glu
            100                 105                 110         
Ser Lys Glu Val Leu Ser Gln Gly Gln Gln Gln Gly Ala Pro Asn Ala
        115                 120                 125             
Gly Val Ile Thr Asn Ala Pro Leu Gln Arg His Phe Lys Pro Lys Lys
    130                 135                 140                 
Val Glu Cys Leu Glu Val Glu Thr Thr Asp Val Thr Gly His Glu Arg
145                 150                 155                 160 
Ile Leu Leu Ser Gln Ala Cys Leu Glu Ile Ser Glu Ala Gln Val Pro
                165                 170                 175     
Ser Lys Pro Phe Gln Asn Val Glu Phe Cys Asp Phe Ser Arg His Glu
            180                 185                 190         
Pro Asp Gly Glu Ala Phe Glu Asp Lys Asp Leu Glu Gly Arg Ile Glu
        195                 200                 205             
Thr Asp Thr Glu Val Leu Glu Ile Leu Tyr Glu Phe Pro Arg Val Phe
    210                 215                 220                 
Ser Ser Val Met Lys Pro Glu Asn Met Ile Val Pro Ile Lys Leu Ser
225                 230                 235                 240 
Ser Asp Ser Glu Ile Val Gln Gln Ser Met Gln Thr Ser Asp Gly Ile
                245                 250                 255     
Leu Asn Pro Ser Ser Gly Gly Ile Thr Thr Thr Ser Val Pro Gly Ser
            260                 265                 270         
Pro Asp Gly Val Phe Asp Gln Thr Cys Val Asp Phe Glu Val Glu Ser
        275                 280                 285             
Val Gly Gly Ile Ala Asn Ser Thr Gly Phe Ile Leu Asp Gln Lys Asp
    290                 295                 300                 
Thr Asp Ser Ile Pro Ala Thr Met Gly His Ile Ser Leu Ser Glu Ser
305                 310                 315                 320 
Thr Asn Asp Thr Val Ser Pro Val Met Ile Arg Glu Cys Glu Lys Asn
                325                 330                 335     
Asp Ser Thr Ala Asp Glu Leu His Val Lys His Glu Pro Pro Asp Thr
            340                 345                 350         
Ala Val Leu Ala His Glu Thr His Arg Asp Ser Gly Phe Lys Asn Val
        355                 360                 365             
Gly Asp Ile Thr Asn Lys Ala Cys Met Met Asp Thr Thr Gly Met Ser
    370                 375                 380                 
Cys Ser Asp His Val Thr Val Asp Ser Pro Tyr Val Val Ala Val Arg
385                 390                 395                 400 
Ile Ala Asp Glu Thr Ser Ile Asn Thr Arg Ser Phe Ser Lys Phe Val
                405                 410                 415     
Gly Met Ser Ala Asp Ala Thr Pro Leu His Val Ala Arg Ser Gly Asn
            420                 425                 430         
Asp Thr Glu Asp Phe Gly Asn Pro Ser Ala Cys Ser Asp Ile Tyr Gly
        435                 440                 445             
Glu Ser Ile Ser Ser His Phe Thr Glu Ser Thr Gly Lys Leu Ile Glu
    450                 455                 460                 
Ser Leu Ser Asp Cys Ala Ser Ser Leu Pro Ile Lys Lys Ile Ala Gly
465                 470                 475                 480 
Ser Asn Tyr Asn Thr Phe Leu Asp Ser Glu Leu Ser Met Leu Asn Gly
                485                 490                 495     
Thr Lys Val Leu Ser Asp Ser Ala Val Gly Ile Asp Leu Gly Ser Thr
            500                 505                 510         
Gly Asp Thr Thr Glu Ala Leu His Glu Leu Arg Thr Ala Glu Glu Phe
        515                 520                 525             
Lys Thr Glu Glu Gln Asp Asp Ser Gly Ser Ile Glu Phe Gly Val Ser
    530                 535                 540                 
Phe Pro Asp Arg Glu Ser Ser Ser Met Glu Thr Ser Ile Glu Pro Lys
545                 550                 555                 560 
Ala Thr Glu Thr Ser His Thr Glu Gly Ile Thr Ala Ile Glu Glu Ser
                565                 570                 575     
Trp Glu Ser Met Phe Asn Asp Asp Gly Asp Cys Leu Asp Pro Arg Leu
            580                 585                 590         
Leu Gln Glu Gly Ile Leu Met His Ile Lys Pro Glu Asn His Cys Ser
        595                 600                 605             
Lys Leu Ser Gly Asn Thr Lys Ser Arg Glu Ser Ile Gln Glu Pro Arg
    610                 615                 620                 
Ser Asp Tyr Tyr Asn His Glu Val Pro Asp Ile Asp Leu Ser Asp Cys
625                 630                 635                 640 
Glu Phe Pro His Val Ile Glu Ile Tyr Asp Phe Pro Gln Glu Phe Arg
                645                 650                 655     
Thr Glu Asp Leu Leu Arg Val Phe Cys Ser Tyr Gln Lys Lys Gly Phe
            660                 665                 670         
Asp Ile Lys Trp Val Asp Asp Thr His Ala Leu Gly Val Phe Ser Ser
        675                 680                 685             
Pro Ile Thr Ala Arg Asp Ala Leu Gly Ile Lys His Thr Met Val Lys
    690                 695                 700                 
Ile Arg Pro Leu Ser Gln Ala Thr Arg Ala Ala Lys Ala Lys Ala Arg
705                 710                 715                 720 
Ala Tyr Ala Glu Phe Leu Gln Pro Ala Lys Glu Arg Pro Glu Thr Ser
                725                 730                 735     
Ala Ala Leu Ala Arg Arg Leu Val Ile Ser Ala Leu Gly Val Arg Ser
            740                 745                 750         
Lys Gln Ser Lys Thr Glu Arg Glu Ala Glu Leu Lys Lys Leu Gln Glu
        755                 760                 765             
Ala Arg Glu Arg Lys Arg Leu Glu Ala Lys Gln Arg Glu Asp Ile Trp
    770                 775                 780                 
Glu Gly Arg Asp Gln Ser Thr Val
785                 790         


<210> 7880
<211> 260
<212> PRT
<213> Homo sapiens

<400> 7880
Met Ile Lys Arg Arg Phe Ala Arg Glu Asn Gln Ser Gln Arg Val Glu
 1               5                  10                  15      
Lys Glu Val Glu Thr Phe Leu Cys Ile Cys Gln Ser His Ala Glu Leu
            20                  25                  30          
Pro Glu Arg Lys Arg Lys Gly Arg Arg Gly Gln Lys Tyr Gln Ile Gln
        35                  40                  45              
Leu Arg Asn Leu Arg Thr Lys Ser Pro Asn Asp Leu His Pro Thr Lys
    50                  55                  60                  
Val Lys Thr Ala Ser Cys Thr Ser Met Pro Leu Ala Glu Thr Gly Ser
65                  70                  75                  80  
Gly Arg Ser Thr Ser Gly Pro Pro Ser Ser Ala Ala Ala Val Gly Met
                85                  90                  95      
Glu Thr Ser Ala Pro Arg Ala Gly Ser Arg Leu Thr Glu Met Ala Ala
            100                 105                 110         
Ser Ser Gln Gly Asn Phe Glu Gly Asp Ile Glu Ser Val Asp Leu Ala
        115                 120                 125             
Glu Phe Ala Lys Gln Gln Pro Trp Trp Arg Lys Leu Phe Gly Pro Glu
    130                 135                 140                 
Ser Gly Leu Ser Ala Glu Lys Tyr Ser Val Ala Thr His Leu Phe Ile
145                 150                 155                 160 
Gly Gly Val Thr Gly Trp Cys Thr Gly Phe Ile Phe Gln Lys Val Gly
                165                 170                 175     
Lys Leu Ala Ala Thr Ala Val Gly Gly Gly Phe Phe Leu Leu Gln Leu
            180                 185                 190         
Ala Asn His Ser Gly Tyr Ile Lys Val Asp Trp Gln Arg Val Glu Lys
        195                 200                 205             
Asp Met Lys Lys Ala Lys Glu Gln Leu Lys Ile Pro Lys Ser Thr Gln
    210                 215                 220                 
Ile Pro Asn Gln Val Arg Ser Lys Ala Glu Glu Val Val Ser Phe Val
225                 230                 235                 240 
Lys Lys Asn Val Leu Val Thr Gly Gly Phe Phe Gly Gly Phe Leu Leu
                245                 250                 255     
Gly Met Ala Ser
            260 


<210> 7881
<211> 147
<212> PRT
<213> Homo sapiens

<400> 7881
Pro Pro Gly Asp Pro Gly Phe Pro Gly Arg Tyr Gly Glu Thr Gly Asp
 1               5                  10                  15      
Val Gly Pro Pro Gly Pro Pro Gly Leu Leu Gly Arg Pro Gly Glu Ala
            20                  25                  30          
Cys Ala Gly Met Ile Gly Pro Pro Gly Pro Gln Gly Phe Pro Gly Leu
        35                  40                  45              
Pro Gly Leu Pro Gly Glu Ala Gly Ile Pro Gly Arg Pro Asp Ser Ala
    50                  55                  60                  
Pro Gly Lys Pro Gly Lys Pro Gly Ser Pro Gly Leu Pro Gly Ala Pro
65                  70                  75                  80  
Gly Leu Gln Gly Leu Pro Gly Ser Ser Gly Asn Met Thr Asn Leu Pro
                85                  90                  95      
Leu Ile Leu Cys Leu Gly Asn Glu Gly Leu Cys Ala Cys Glu Pro Gly
            100                 105                 110         
Pro Met Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Arg Gln Gly Ser
        115                 120                 125             
Lys Gly Asp Leu Gly Leu Pro Gly Trp Leu Gly Thr Lys Gly Asp Pro
    130                 135                 140                 
Gly Pro Pro
145         


<210> 7882
<211> 1978
<212> PRT
<213> Homo sapiens

<400> 7882
Met Ser Arg Pro Arg Phe Asn Pro Arg Gly Asp Phe Pro Leu Gln Arg
 1               5                  10                  15      
Pro Arg Ala Pro Asn Pro Ser Gly Met Arg Pro Pro Gly Pro Phe Met
            20                  25                  30          
Arg Pro Gly Ser Met Gly Leu Pro Arg Phe Tyr Pro Ala Gly Arg Ala
        35                  40                  45              
Arg Gly Ile Pro His Arg Phe Ala Gly Leu Glu Ser Tyr Gln Asn Met
    50                  55                  60                  
Gly Pro Gln Arg Met Asn Val Gln Val Thr Gln His Arg Thr Asp Pro
65                  70                  75                  80  
Arg Leu Thr Lys Glu Lys Leu Asp Phe His Glu Ala Gln Gln Lys Lys
                85                  90                  95      
Gly Lys Pro His Gly Ser Arg Trp Asp Asp Glu Pro His Ile Ser Ala
            100                 105                 110         
Ser Val Ala Val Lys Gln Ser Ser Val Thr Gln Val Thr Glu Gln Ser
        115                 120                 125             
Pro Lys Val Gln Ser Arg Tyr Thr Lys Glu Ser Ala Ser Ser Ile Leu
    130                 135                 140                 
Ala Ser Phe Gly Leu Ser Asn Glu Asp Leu Glu Glu Leu Ser Arg Tyr
145                 150                 155                 160 
Pro Asp Glu Gln Leu Thr Pro Glu Asn Met Pro Leu Ile Leu Arg Asp
                165                 170                 175     
Ile Arg Met Arg Lys Met Gly Arg Arg Leu Pro Asn Leu Pro Ser Gln
            180                 185                 190         
Ser Arg Asn Lys Glu Thr Leu Gly Ser Glu Ala Val Ser Ser Asn Val
        195                 200                 205             
Ile Asp Tyr Gly His Ala Ser Lys Tyr Gly Tyr Thr Glu Asp Pro Leu
    210                 215                 220                 
Glu Val Arg Ile Tyr Asp Pro Glu Ile Pro Thr Asp Glu Val Glu Asn
225                 230                 235                 240 
Glu Phe Gln Ser Gln Gln Asn Ile Ser Ala Ser Val Pro Asn Pro Asn
                245                 250                 255     
Val Ile Cys Asn Ser Met Phe Pro Val Glu Asp Val Phe Arg Gln Met
            260                 265                 270         
Asp Phe Pro Gly Glu Ser Ser Asn Asn Arg Ser Phe Phe Ser Val Glu
        275                 280                 285             
Ser Gly Thr Lys Met Ser Gly Leu His Ile Ser Gly Gly Gln Ser Val
    290                 295                 300                 
Leu Glu Pro Ile Lys Ser Val Asn Gln Ser Ile Asn Gln Thr Val Ser
305                 310                 315                 320 
Gln Thr Met Ser Gln Ser Leu Ile Pro Pro Ser Met Asn Gln Gln Pro
                325                 330                 335     
Phe Ser Ser Glu Leu Ile Ser Ser Val Ser Gln Gln Glu Arg Ile Pro
            340                 345                 350         
His Glu Pro Val Ile Asn Ser Ser Asn Val His Val Gly Ser Arg Gly
        355                 360                 365             
Ser Lys Lys Asn Tyr Gln Ser Gln Ala Asp Ile Pro Ile Arg Ser Pro
    370                 375                 380                 
Phe Gly Ile Val Lys Ala Ser Trp Leu Pro Lys Phe Ser His Ala Asp
385                 390                 395                 400 
Ala Gln Lys Met Lys Arg Leu Pro Thr Pro Ser Met Met Asn Asp Tyr
                405                 410                 415     
Tyr Ala Ala Ser Pro Arg Ile Phe Pro His Leu Cys Ser Leu Cys Asn
            420                 425                 430         
Val Glu Cys Ser His Leu Lys Asp Trp Ile Gln His Gln Asn Thr Ser
        435                 440                 445             
Thr His Ile Glu Ser Cys Arg Gln Leu Arg Gln Gln Tyr Pro Asp Trp
    450                 455                 460                 
Asn Pro Glu Ile Leu Pro Ser Arg Arg Asn Glu Gly Asn Arg Lys Glu
465                 470                 475                 480 
Asn Glu Thr Pro Arg Arg Arg Ser His Ser Pro Ser Pro Arg Arg Ser
                485                 490                 495     
Arg Arg Ser Ser Ser Ser His Arg Phe Arg Arg Ser Arg Ser Pro Met
            500                 505                 510         
His Tyr Met Tyr Arg Pro Arg Ser Arg Ser Pro Arg Ile Cys His Arg
        515                 520                 525             
Phe Ile Ser Arg Tyr Arg Ser Arg Ser Arg Ser Arg Ser Pro Tyr Arg
    530                 535                 540                 
Ile Arg Asn Pro Phe Arg Gly Ser Pro Lys Cys Phe Arg Ser Val Ser
545                 550                 555                 560 
Pro Glu Arg Met Ser Arg Arg Ser Val Arg Ser Ser Asp Arg Lys Lys
                565                 570                 575     
Ala Leu Glu Asp Val Val Gln Arg Ser Gly His Gly Thr Glu Phe Asn
            580                 585                 590         
Lys Gln Lys His Leu Glu Ala Ala Asp Lys Gly His Ser Pro Ala Gln
        595                 600                 605             
Lys Pro Lys Thr Ser Ser Gly Thr Lys Pro Ser Val Lys Pro Thr Ser
    610                 615                 620                 
Ala Thr Lys Ser Asp Ser Asn Leu Gly Gly His Ser Ile Arg Cys Lys
625                 630                 635                 640 
Ser Lys Asn Leu Glu Asp Asp Thr Leu Ser Glu Cys Lys Gln Val Ser
                645                 650                 655     
Asp Lys Ala Val Ser Leu Gln Arg Lys Leu Arg Lys Glu Gln Ser Leu
            660                 665                 670         
His Tyr Gly Ser Val Leu Leu Ile Thr Glu Leu Pro Glu Asp Gly Cys
        675                 680                 685             
Thr Glu Glu Asp Val Arg Lys Leu Phe Gln Pro Phe Gly Lys Val Asn
    690                 695                 700                 
Asp Val Leu Ile Val Pro Tyr Arg Lys Glu Ala Tyr Leu Glu Met Glu
705                 710                 715                 720 
Phe Lys Glu Ala Ile Thr Ala Ile Met Lys Tyr Ile Glu Thr Thr Pro
                725                 730                 735     
Leu Thr Ile Lys Gly Lys Ser Val Lys Ile Cys Val Pro Gly Lys Lys
            740                 745                 750         
Lys Ala Gln Asn Lys Glu Val Lys Lys Lys Thr Leu Glu Ser Lys Lys
        755                 760                 765             
Val Ser Ala Ser Thr Leu Lys Arg Asp Ala Asp Ala Ser Lys Ala Val
    770                 775                 780                 
Glu Ile Val Thr Ser Thr Ser Ala Ala Lys Thr Gly Gln Ala Lys Ala
785                 790                 795                 800 
Cys Val Ala Lys Val Asn Lys Ser Thr Gly Lys Ser Ala Ser Ser Val
                805                 810                 815     
Lys Ser Val Val Thr Val Ala Val Lys Gly Asn Lys Ala Ser Ile Lys
            820                 825                 830         
Thr Ala Lys Ser Gly Gly Lys Lys Ser Leu Glu Ala Lys Lys Thr Gly
        835                 840                 845             
Asn Val Lys Asn Lys Asp Ser Asn Lys Pro Val Thr Ile Pro Glu Asn
    850                 855                 860                 
Ser Glu Ile Lys Thr Ser Ile Glu Val Lys Ala Thr Glu Asn Cys Ala
865                 870                 875                 880 
Lys Glu Ala Ile Ser Asp Ala Ala Leu Glu Ala Thr Glu Asn Glu Pro
                885                 890                 895     
Leu Asn Lys Glu Thr Glu Glu Met Cys Val Met Leu Val Ser Asn Leu
            900                 905                 910         
Pro Asn Lys Gly Tyr Ser Val Glu Glu Val Tyr Asp Leu Ala Lys Pro
        915                 920                 925             
Phe Gly Gly Leu Lys Asp Ile Leu Ile Leu Ser Ser His Lys Lys Ala
    930                 935                 940                 
Tyr Ile Glu Ile Asn Arg Lys Ala Ala Glu Ser Met Val Lys Phe Tyr
945                 950                 955                 960 
Thr Cys Phe Pro Val Leu Met Asp Gly Asn Gln Leu Ser Ile Ser Met
                965                 970                 975     
Ala Pro Glu Asn Met Asn Ile Lys Asp Glu Glu Ala Ile Phe Ile Thr
            980                 985                 990         
Leu Val Lys Glu Asn Asp Pro Glu Ala Asn Ile Asp Thr Ile Tyr Asp
        995                 1000                1005            
Arg Phe Val His Leu Asp Asn Leu Pro Glu Asp Gly Leu Gln Cys Val
    1010                1015                1020                
Leu Cys Val Gly Leu Gln Phe Gly Lys Val Asp His His Val Phe Ile
1025                1030                1035                1040
Ser Asn Arg Asn Lys Ala Ile Leu Gln Leu Asp Ser Pro Glu Ser Ala
                1045                1050                1055    
Gln Ser Met Tyr Ser Phe Leu Lys Gln Asn Pro Gln Asn Ile Gly Asp
            1060                1065                1070        
His Met Leu Thr Cys Ser Leu Ser Pro Lys Ile Asp Leu Pro Glu Val
        1075                1080                1085            
Gln Ile Glu His Asp Pro Glu Leu Glu Lys Glu Ser Pro Gly Leu Lys
    1090                1095                1100                
Asn Ser Pro Ile Asp Glu Ser Glu Val Gln Thr Ala Thr Asp Ser Pro
1105                1110                1115                1120
Ser Val Lys Pro Asn Glu Leu Glu Glu Glu Ser Thr Pro Ser Ile Gln
                1125                1130                1135    
Thr Glu Thr Leu Val Gln Gln Glu Glu Pro Cys Glu Glu Glu Ala Glu
            1140                1145                1150        
Lys Ala Thr Cys Asp Ser Asp Phe Ala Val Glu Thr Leu Glu Leu Glu
        1155                1160                1165            
Thr Gln Gly Glu Glu Val Lys Glu Glu Ile Pro Leu Val Ala Ser Ala
    1170                1175                1180                
Ser Val Ser Ile Glu Gln Phe Thr Glu Asn Ala Glu Glu Cys Ala Leu
1185                1190                1195                1200
Asn Gln Gln Met Phe Asn Ser Asp Leu Glu Lys Lys Gly Ala Glu Ile
                1205                1210                1215    
Ile Asn Pro Lys Thr Ala Leu Leu Pro Ser Asp Ser Val Phe Ala Glu
            1220                1225                1230        
Glu Arg Asn Leu Lys Gly Ile Leu Glu Glu Ser Pro Ser Glu Ala Glu
        1235                1240                1245            
Asp Phe Ile Ser Gly Ile Thr Gln Thr Met Val Glu Ala Val Ala Glu
    1250                1255                1260                
Val Glu Lys Asn Glu Thr Val Ser Glu Ile Leu Pro Ser Thr Cys Ile
1265                1270                1275                1280
Val Thr Leu Val Pro Gly Ile Pro Thr Gly Asp Glu Lys Thr Val Asp
                1285                1290                1295    
Lys Lys Asn Ile Ser Glu Lys Lys Gly Asn Met Asp Glu Lys Glu Glu
            1300                1305                1310        
Lys Glu Phe Asn Thr Lys Glu Thr Arg Met Asp Leu Gln Ile Gly Thr
        1315                1320                1325            
Glu Lys Ala Glu Lys Asn Glu Gly Arg Met Asp Ala Glu Lys Val Glu
    1330                1335                1340                
Lys Met Ala Ala Met Lys Glu Lys Pro Ala Glu Asn Thr Leu Phe Lys
1345                1350                1355                1360
Ala Tyr Pro Asn Lys Gly Val Gly Gln Ala Asn Lys Pro Asp Glu Thr
                1365                1370                1375    
Ser Lys Thr Ser Ile Leu Ala Val Ser Asp Val Ser Ser Ser Lys Pro
            1380                1385                1390        
Ser Ile Lys Ala Val Ile Val Ser Ser Pro Lys Ala Lys Ala Thr Val
        1395                1400                1405            
Ser Lys Thr Glu Asn Gln Lys Ser Phe Pro Lys Ser Val Pro Arg Asp
    1410                1415                1420                
Gln Ile Asn Ala Glu Lys Lys Leu Ser Ala Lys Glu Phe Gly Leu Leu
1425                1430                1435                1440
Lys Pro Thr Ser Ala Arg Ser Gly Leu Ala Glu Ser Ser Ser Lys Phe
                1445                1450                1455    
Lys Pro Thr Gln Ser Ser Leu Thr Arg Gly Gly Ser Gly Arg Ile Ser
            1460                1465                1470        
Ala Leu Gln Gly Lys Leu Ser Lys Leu Asp Tyr Arg Asp Ile Thr Lys
        1475                1480                1485            
Gln Ser Gln Glu Thr Glu Ala Arg Pro Ser Ile Met Lys Arg Asp Asp
    1490                1495                1500                
Ser Asn Asn Lys Thr Leu Ala Glu Gln Asn Thr Lys Asn Pro Lys Ser
1505                1510                1515                1520
Thr Thr Gly Arg Ser Ser Lys Ser Lys Glu Glu Pro Leu Phe Pro Phe
                1525                1530                1535    
Asn Leu Asp Glu Phe Val Thr Val Asp Glu Val Ile Glu Glu Val Asn
            1540                1545                1550        
Pro Ser Gln Ala Lys Gln Asn Pro Leu Lys Gly Lys Arg Lys Glu Thr
        1555                1560                1565            
Leu Lys Asn Val Pro Phe Ser Glu Leu Asn Leu Lys Lys Lys Lys Gly
    1570                1575                1580                
Lys Thr Ser Thr Pro Arg Gly Val Glu Gly Glu Leu Ser Phe Val Thr
1585                1590                1595                1600
Leu Asp Glu Ile Gly Glu Glu Glu Asp Ala Ala Ala His Leu Ala Gln
                1605                1610                1615    
Ala Leu Val Thr Val Asp Glu Val Ile Asp Glu Glu Glu Leu Asn Met
            1620                1625                1630        
Glu Glu Met Val Lys Asn Ser Asn Ser Leu Phe Thr Leu Asp Glu Leu
        1635                1640                1645            
Ile Asp Gln Asp Asp Cys Ile Ser His Ser Glu Pro Lys Asp Val Thr
    1650                1655                1660                
Val Leu Ser Val Ala Glu Glu Gln Asp Leu Leu Lys Gln Glu Arg Leu
1665                1670                1675                1680
Val Thr Val Asp Glu Ile Gly Glu Val Glu Glu Leu Pro Leu Asn Glu
                1685                1690                1695    
Ser Ala Asp Ile Thr Phe Ala Thr Leu Asn Thr Lys Gly Asn Glu Gly
            1700                1705                1710        
Asp Ile Val Arg Asp Ser Ile Gly Phe Ile Ser Ser Gln Val Pro Glu
        1715                1720                1725            
Asp Pro Ser Thr Leu Val Thr Val Asp Glu Ile Gln Asp Asp Ser Ser
    1730                1735                1740                
Asp Leu His Leu Val Thr Leu Asp Glu Val Thr Glu Glu Asp Glu Asp
1745                1750                1755                1760
Ser Leu Ala Asp Phe Asn Asn Leu Lys Glu Glu Leu Asn Phe Val Thr
                1765                1770                1775    
Val Asp Glu Val Gly Glu Glu Glu Asp Gly Asp Asn Asp Leu Lys Val
            1780                1785                1790        
Glu Leu Ala Gln Ser Lys Asn Asp His Pro Thr Asp Lys Lys Gly Asn
        1795                1800                1805            
Arg Lys Lys Arg Ala Val Asp Thr Lys Lys Thr Lys Leu Glu Ser Leu
    1810                1815                1820                
Ser Gln Val Gly Pro Val Asn Glu Asn Val Met Glu Glu Asp Leu Lys
1825                1830                1835                1840
Thr Met Ile Glu Arg His Leu Thr Ala Lys Thr Pro Thr Lys Arg Val
                1845                1850                1855    
Arg Ile Gly Lys Thr Leu Pro Ser Glu Lys Ala Val Val Thr Glu Pro
            1860                1865                1870        
Ala Lys Gly Glu Glu Ala Phe Gln Met Ser Glu Val Asp Glu Glu Ser
        1875                1880                1885            
Gly Leu Lys Asp Ser Glu Pro Glu Arg Lys Arg Lys Lys Thr Glu Asp
    1890                1895                1900                
Ser Ser Ser Gly Lys Ser Val Ala Ser Asp Val Pro Glu Glu Leu Asp
1905                1910                1915                1920
Phe Leu Val Pro Lys Ala Gly Phe Phe Cys Pro Ile Cys Ser Leu Phe
                1925                1930                1935    
Tyr Ser Gly Glu Lys Ala Met Thr Asn His Cys Lys Ser Thr Arg His
            1940                1945                1950        
Lys Gln Asn Thr Glu Lys Phe Met Ala Lys Gln Arg Lys Glu Lys Glu
        1955                1960                1965            
Gln Asn Glu Ala Glu Glu Arg Ser Ser Arg
    1970                1975            


<210> 7883
<211> 767
<212> PRT
<213> Homo sapiens

<400> 7883
Met Phe Ala Lys Leu Lys Lys Lys Ile Ala Glu Glu Thr Ala Val Ala
 1               5                  10                  15      
Gln Arg Pro Gly Gly Ala Thr Arg Ile Pro Arg Ser Val Ser Lys Glu
            20                  25                  30          
Ser Val Ala Ser Met Gly Ala Asp Ser Gly Asp Asp Phe Ala Ser Asp
        35                  40                  45              
Gly Ser Ser Ser Arg Glu Asp Leu Ser Ser Gln Leu Leu Arg Arg Asn
    50                  55                  60                  
Glu Gln Ile Arg Lys Leu Glu Ala Arg Leu Ser Asp Tyr Ala Glu Gln
65                  70                  75                  80  
Val Arg Asn Leu Gln Lys Ile Lys Glu Lys Leu Glu Ile Ala Leu Glu
                85                  90                  95      
Lys His Gln Asp Ser Ser Met Arg Lys Phe Gln Glu Gln Asn Glu Thr
            100                 105                 110         
Phe Gln Ala Asn Arg Ala Lys Met Ala Glu Gly Leu Ala Leu Ala Leu
        115                 120                 125             
Ala Arg Lys Asp Gln Glu Trp Ser Glu Lys Met Asp Gln Leu Glu Lys
    130                 135                 140                 
Glu Lys Asn Ile Leu Thr Ala Gln Leu Gln Glu Met Lys Asn Gln Ser
145                 150                 155                 160 
Met Asn Leu Phe Gln Arg Arg Asp Glu Met Asp Glu Leu Glu Gly Phe
                165                 170                 175     
Gln Gln Gln Glu Leu Ser Lys Ile Lys His Met Leu Leu Lys Lys Glu
            180                 185                 190         
Glu Ser Leu Gly Lys Met Glu Gln Glu Leu Glu Ala Arg Thr Arg Glu
        195                 200                 205             
Leu Ser Arg Thr Gln Glu Glu Leu Met Asn Ser Asn Gln Met Ser Ser
    210                 215                 220                 
Asp Leu Ser Gln Lys Leu Glu Glu Leu Gln Arg His Tyr Ser Thr Leu
225                 230                 235                 240 
Glu Glu Gln Arg Asp His Val Ile Ala Ser Lys Thr Gly Ala Glu Ser
                245                 250                 255     
Lys Ile Thr Ala Leu Glu Gln Lys Glu Gln Glu Leu Gln Ala Leu Ile
            260                 265                 270         
Gln Gln Leu Ser Ile Asp Leu Gln Lys Val Thr Ala Glu Thr Gln Glu
        275                 280                 285             
Lys Glu Asp Val Ile Thr His Leu Gln Glu Lys Val Ala Ser Leu Glu
    290                 295                 300                 
Lys Arg Leu Glu Gln Asn Leu Ser Gly Glu Glu His Val Gln Glu Leu
305                 310                 315                 320 
Leu Lys Glu Lys Thr Leu Ala Glu Gln Asn Leu Glu Asp Thr Arg Gln
                325                 330                 335     
Gln Leu Leu Ala Ala Arg Ser Ser Gln Ala Lys Ala Ile Asn Thr Leu
            340                 345                 350         
Glu Thr Arg Val Arg Glu Leu Glu Gln Thr Leu Gln Ala Ser Glu Glu
        355                 360                 365             
Gln Leu Gln Gln Ser Lys Gly Ile Val Ala Ala Gln Glu Thr Gln Ile
    370                 375                 380                 
Gln Glu Leu Ala Ala Ala Asn Gln Glu Ser Ser His Val Gln Gln Gln
385                 390                 395                 400 
Ala Leu Ala Leu Glu Gln Gln Phe Leu Glu Arg Thr Gln Ala Leu Glu
                405                 410                 415     
Ala Gln Ile Val Ala Leu Glu Arg Met Arg Ala Ala Asp Gln Thr Thr
            420                 425                 430         
Ala Glu Gln Gly Met Arg Gln Leu Glu Gln Glu Asn Ala Ala Leu Lys
        435                 440                 445             
Glu Cys Arg Asn Glu Tyr Glu Arg Ser Leu Gln Asn His Gln Phe Glu
    450                 455                 460                 
Leu Lys Lys Leu Lys Glu Glu Trp Ser Gln Arg Glu Ile Val Ser Val
465                 470                 475                 480 
Ala Met Ala Gln Ala Leu Glu Glu Val Arg Lys Gln Arg Glu Glu Phe
                485                 490                 495     
Gln Gln Gln Ala Ala Asn Leu Thr Ala Ile Ile Asp Glu Lys Glu Gln
            500                 505                 510         
Asn Leu Arg Glu Lys Thr Glu Val Leu Leu Gln Lys Glu Gln Glu Ile
        515                 520                 525             
Leu Gln Leu Glu Arg Gly His Asn Ser Ala Leu Leu Gln Ile His Gln
    530                 535                 540                 
Leu Gln Ala Glu Leu Glu Ala Leu Arg Thr Leu Lys Ala Glu Glu Ala
545                 550                 555                 560 
Ala Val Val Ala Glu Gln Glu Asp Leu Leu Arg Leu Arg Gly Pro Leu
                565                 570                 575     
Gln Ala Glu Ala Leu Ser Val Asn Glu Ser His Val Thr Ser Arg Ala
            580                 585                 590         
Met Gln Asp Pro Val Phe Gln Leu Pro Thr Ala Gly Arg Thr Pro Asn
        595                 600                 605             
Gly Glu Val Gly Ala Met Asp Leu Thr Gln Leu Gln Lys Glu Lys Gln
    610                 615                 620                 
Asp Leu Glu Gln Gln Leu Leu Glu Lys Asn Lys Thr Ile Lys Gln Met
625                 630                 635                 640 
Gln Gln Arg Met Leu Glu Leu Arg Lys Thr Leu Gln Lys Glu Leu Lys
                645                 650                 655     
Ile Arg Pro Asp Asn Glu Leu Phe Glu Val Arg Glu Lys Pro Gly Pro
            660                 665                 670         
Glu Met Ala Asn Met Ala Pro Ser Val Thr Asn Asn Thr Asp Leu Thr
        675                 680                 685             
Asp Ala Arg Glu Ile Asn Phe Glu Tyr Leu Lys His Val Val Leu Lys
    690                 695                 700                 
Phe Met Ser Cys Arg Glu Ser Glu Ala Phe His Leu Ile Lys Ala Val
705                 710                 715                 720 
Ser Val Leu Leu Asn Phe Ser Gln Glu Glu Glu Asn Met Leu Lys Glu
                725                 730                 735     
Thr Leu Glu Tyr Lys Met Ser Trp Phe Gly Ser Lys Pro Ala Pro Lys
            740                 745                 750         
Gly Ser Ile Arg Pro Ser Ile Ser Asn Pro Arg Ile Pro Trp Ser
        755                 760                 765         


<210> 7884
<211> 560
<212> PRT
<213> Homo sapiens

<400> 7884
Met Ser Glu His Ser Arg Asn Ser Asp Gln Glu Glu Leu Leu Asp Glu
 1               5                  10                  15      
Glu Ile Asn Glu Asp Glu Ile Leu Ala Asn Leu Ser Ala Glu Glu Leu
            20                  25                  30          
Lys Glu Leu Gln Ser Glu Met Glu Val Met Ala Pro Asp Pro Ser Leu
        35                  40                  45              
Pro Val Gly Met Ile Gln Lys Asp Gln Thr Asp Lys Pro Pro Thr Gly
    50                  55                  60                  
Asn Phe Asn His Lys Ser Leu Val Asp Tyr Met Tyr Trp Glu Lys Ala
65                  70                  75                  80  
Ser Arg Arg Met Leu Glu Glu Glu Arg Val Pro Val Thr Phe Val Lys
                85                  90                  95      
Ser Glu Glu Lys Thr Gln Glu Glu His Glu Glu Ile Glu Lys Arg Asn
            100                 105                 110         
Lys Asn Met Ala Gln Tyr Leu Lys Glu Lys Leu Asn Asn Glu Ile Val
        115                 120                 125             
Ala Asn Lys Arg Glu Ser Lys Gly Ser Ser Asn Ile Gln Glu Thr Asp
    130                 135                 140                 
Glu Glu Asp Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp Glu Gly Glu
145                 150                 155                 160 
Asp Asp Gly Glu Glu Ser Glu Glu Thr Asn Arg Glu Glu Glu Gly Lys
                165                 170                 175     
Ala Lys Glu Gln Ile Arg Asn Cys Glu Asn Asn Cys Gln Gln Val Thr
            180                 185                 190         
Asp Lys Ala Phe Lys Glu Gln Arg Asp Arg Pro Glu Ala Gln Glu Gln
        195                 200                 205             
Ser Glu Lys Lys Ile Ser Lys Leu Asp Pro Lys Lys Leu Ala Leu Asp
    210                 215                 220                 
Thr Ser Phe Leu Lys Val Ser Thr Arg Pro Ser Gly Asn Gln Thr Asp
225                 230                 235                 240 
Leu Asp Gly Ser Leu Arg Arg Val Arg Lys Asn Asp Pro Asp Met Lys
                245                 250                 255     
Glu Leu Asn Leu Asn Asn Ile Glu Asn Ile Pro Lys Glu Met Leu Leu
            260                 265                 270         
Asp Phe Val Asn Ala Met Lys Lys Asn Lys His Ile Lys Thr Phe Ser
        275                 280                 285             
Leu Ala Asn Val Gly Ala Asp Glu Asn Val Ala Phe Ala Leu Ala Asn
    290                 295                 300                 
Met Leu Arg Glu Asn Arg Ser Ile Thr Thr Leu Asn Ile Glu Ser Asn
305                 310                 315                 320 
Phe Ile Thr Gly Lys Gly Ile Val Ala Ile Met Arg Cys Leu Gln Phe
                325                 330                 335     
Asn Glu Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Met Leu
            340                 345                 350         
Gly His His Ala Glu Met Glu Ile Ala Arg Leu Leu Lys Ala Asn Asn
        355                 360                 365             
Thr Leu Leu Lys Met Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met
    370                 375                 380                 
Val Val Thr Asn Leu Leu Thr Arg Asn Gln Asp Lys Gln Arg Gln Lys
385                 390                 395                 400 
Arg Gln Glu Glu Gln Lys Gln Gln Gln Leu Lys Glu Gln Lys Lys Leu
                405                 410                 415     
Ile Ala Met Leu Glu Asn Gly Leu Gly Leu Pro Pro Gly Met Trp Glu
            420                 425                 430         
Leu Leu Gly Gly Pro Lys Pro Asp Ser Arg Met Gln Glu Phe Phe Gln
        435                 440                 445             
Pro Pro Pro Pro Arg Pro Pro Asn Pro Gln Asn Val Pro Phe Ser Gln
    450                 455                 460                 
Arg Ser Glu Met Met Lys Lys Pro Ser Gln Ala Pro Lys Tyr Arg Thr
465                 470                 475                 480 
Asp Pro Asp Ser Phe Arg Val Val Lys Leu Lys Arg Ile Gln Arg Lys
                485                 490                 495     
Ser Arg Met Pro Glu Ala Arg Glu Pro Pro Glu Lys Thr Asn Leu Lys
            500                 505                 510         
Asp Val Ile Lys Thr Leu Lys Pro Val Pro Arg Asn Arg Pro Pro Pro
        515                 520                 525             
Leu Val Glu Ile Thr Pro Arg Asp Gln Leu Leu Asn Asp Ile Arg His
    530                 535                 540                 
Ser Ser Val Ala Tyr Leu Lys Pro Val Gln Leu Pro Lys Glu Leu Ala
545                 550                 555                 560 


<210> 7885
<211> 350
<212> PRT
<213> Homo sapiens

<400> 7885
Met Tyr Trp Glu Lys Ala Ser Arg Arg Met Leu Glu Glu Glu Arg Val
 1               5                  10                  15      
Pro Val Thr Phe Val Lys Ser Glu Tyr Leu Lys Glu Lys Leu Asn Asn
            20                  25                  30          
Glu Ile Val Ala Asn Lys Arg Glu Ser Lys Gly Ser Ser Asn Ile Gln
        35                  40                  45              
Glu Thr Asp Glu Glu Asp Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp
    50                  55                  60                  
Glu Gly Glu Asp Asp Gly Glu Glu Ser Glu Glu Thr Asn Arg Glu Glu
65                  70                  75                  80  
Glu Gly Lys Ala Lys Glu Gln Ile Arg Asn Cys Glu Asn Asn Cys Gln
                85                  90                  95      
Gln Val Thr Asp Lys Ala Phe Lys Glu Gln Arg Asp Arg Pro Glu Ala
            100                 105                 110         
Gln Glu Gln Ser Glu Lys Lys Ile Ser Lys Leu Asp Pro Lys Lys Leu
        115                 120                 125             
Ala Leu Asp Thr Ser Phe Leu Lys Val Ser Thr Arg Pro Ser Gly Asn
    130                 135                 140                 
Gln Thr Asp Leu Asp Gly Ser Leu Arg Arg Val Arg Lys Asn Asp Pro
145                 150                 155                 160 
Asp Met Lys Glu Leu Asn Leu Asn Asn Ile Glu Asn Ile Pro Lys Glu
                165                 170                 175     
Met Leu Leu Asp Phe Val Asn Ala Met Lys Lys Asn Lys His Ile Lys
            180                 185                 190         
Thr Phe Ser Leu Ala Asn Val Gly Ala Asp Glu Asn Val Ala Phe Ala
        195                 200                 205             
Leu Ala Asn Met Leu Arg Glu Asn Arg Ser Ile Thr Thr Leu Asn Ile
    210                 215                 220                 
Glu Ser Asn Phe Ile Thr Gly Lys Gly Ile Val Ala Ile Met Arg Cys
225                 230                 235                 240 
Leu Gln Phe Asn Glu Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg
                245                 250                 255     
His Met Leu Gly His His Ala Glu Met Glu Ile Ala Arg Leu Leu Lys
            260                 265                 270         
Ala Asn Asn Thr Leu Leu Lys Met Gly Tyr His Phe Glu Leu Pro Gly
        275                 280                 285             
Pro Arg Met Val Val Thr Asn Leu Leu Thr Arg Asn Gln Asp Lys Gln
    290                 295                 300                 
Arg Gln Lys Arg Gln Glu Glu Gln Lys Gln Gln Gln Leu Lys Glu Gln
305                 310                 315                 320 
Lys Lys Leu Ile Ala Met Leu Glu Asn Gly Leu Gly Leu Pro Pro Gly
                325                 330                 335     
Met Trp Glu Leu Leu Gly Gly Pro Lys Pro Asp Ser Arg Met
            340                 345                 350 


<210> 7886
<211> 222
<212> PRT
<213> Homo sapiens

<400> 7886
Met Asp Leu Leu Phe Gly Arg Arg Lys Thr Pro Glu Glu Leu Leu Arg
 1               5                  10                  15      
Gln Asn Gln Arg Ala Leu Asn Arg Ala Met Arg Glu Leu Asp Arg Glu
            20                  25                  30          
Arg Gln Lys Leu Glu Thr Gln Glu Lys Lys Ile Ile Ala Asp Ile Lys
        35                  40                  45              
Lys Met Ala Lys Gln Gly Gln Met Asp Ala Val Arg Ile Met Ala Lys
    50                  55                  60                  
Asp Leu Val Arg Thr Arg Arg Tyr Val Arg Lys Phe Val Leu Met Arg
65                  70                  75                  80  
Ala Asn Ile Gln Ala Val Ser Leu Lys Ile Gln Thr Leu Lys Ser Asn
                85                  90                  95      
Asn Ser Met Ala Gln Ala Met Lys Gly Val Thr Lys Ala Met Gly Thr
            100                 105                 110         
Met Asn Arg Gln Leu Lys Leu Pro Gln Ile Gln Lys Ile Met Met Glu
        115                 120                 125             
Phe Glu Arg Gln Ala Glu Ile Met Asp Met Lys Glu Glu Met Met Asn
    130                 135                 140                 
Asp Ala Ile Asp Asp Ala Met Gly Asp Glu Glu Asp Glu Glu Glu Ser
145                 150                 155                 160 
Asp Ala Val Val Ser Gln Val Leu Asp Glu Leu Gly Leu Ser Leu Thr
                165                 170                 175     
Asp Glu Leu Ser Asn Leu Pro Ser Thr Gly Gly Ser Leu Ser Val Ala
            180                 185                 190         
Ala Gly Gly Lys Lys Ala Glu Ala Ala Ala Ser Ala Leu Ala Asp Ala
        195                 200                 205             
Asp Ala Asp Leu Glu Glu Arg Leu Lys Asn Leu Arg Arg Asp
    210                 215                 220         


<210> 7887
<211> 756
<212> PRT
<213> Homo sapiens

<400> 7887
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr
 1               5                  10                  15      
Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val
            20                  25                  30          
Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His Gly Gln Asn
        35                  40                  45              
Asn Pro Val Gly Asp Tyr Glu His Ala Asp Asp Gln Ala Glu Glu Asp
    50                  55                  60                  
Ala Leu Gln Met Ala Val Gly Tyr Phe Glu Lys Gly Pro Ile Lys Ala
65                  70                  75                  80  
Ser Gln Asn Lys Asp Lys Thr Leu Glu Lys His Leu Lys Thr Val Glu
                85                  90                  95      
Asn Val Ala Trp Lys Asn Gly Leu Ala Ser Glu Glu Ile Asp Ile Leu
            100                 105                 110         
Leu Asn Ile Ala Leu Ser Gly Lys Phe Gly Asn Ala Val Asn Thr Arg
        115                 120                 125             
Ile Leu Lys Cys Met Ile Pro Ala Thr Val Ile Ser Glu Asp Ser Val
    130                 135                 140                 
Val Lys Ala Val Ser Trp Leu Cys Val Gly Lys Cys Ser Gly Ser Thr
145                 150                 155                 160 
Lys Val Leu Phe Tyr Arg Trp Leu Val Ala Met Phe Asp Phe Ile Asp
                165                 170                 175     
Arg Lys Glu Gln Ile Asn Leu Leu Tyr Gly Phe Phe Phe Ala Ser Leu
            180                 185                 190         
Gln Asp Asp Ala Leu Cys Pro Tyr Val Cys His Leu Leu Tyr Leu Leu
        195                 200                 205             
Thr Lys Lys Glu Asn Val Lys Pro Phe Arg Val Arg Lys Leu Leu Asp
    210                 215                 220                 
Leu Gln Ala Lys Met Gly Met Gln Pro His Leu Gln Ala Leu Leu Ser
225                 230                 235                 240 
Leu Tyr Lys Phe Phe Ala Pro Ala Leu Ile Ser Val Ser Leu Pro Val
                245                 250                 255     
Arg Lys Lys Ile Tyr Leu Gln Asn Ser Glu Asn Leu Trp Lys Thr Ala
            260                 265                 270         
Leu Leu Ala Val Lys Gln Arg Asn Arg Gly Pro Ser Pro Glu Pro Leu
        275                 280                 285             
Lys Leu Met Leu Gly Pro Ala Asn Val Arg Pro Leu Lys Arg Lys Trp
    290                 295                 300                 
Asn Ser Leu Ser Val Ile Pro Val Leu Asn Ser Ser Ser Tyr Thr Lys
305                 310                 315                 320 
Glu Cys Gly Lys Lys Glu Met Ser Leu Ser Asp Cys Leu Asn Arg Ser
                325                 330                 335     
Gly Ser Phe Pro Leu Glu Gln Leu Gln Ser Phe Pro Gln Leu Leu Gln
            340                 345                 350         
Asn Ile His Cys Leu Glu Leu Pro Ser Gln Met Gly Ser Val Leu Asn
        355                 360                 365             
Asn Ser Leu Leu Leu His Tyr Ile Asn Cys Val Arg Asp Glu Pro Val
    370                 375                 380                 
Leu Leu Arg Phe His Tyr Trp Leu Ser Gln Thr Leu Gln Glu Glu Cys
385                 390                 395                 400 
Ile Trp Tyr Lys Val Asn Asn Tyr Glu His Gly Lys Glu Phe Thr Asn
                405                 410                 415     
Phe Leu Asp Thr Ile Ile Arg Ala Glu Cys Phe Leu Gln Glu Gly Tyr
            420                 425                 430         
Tyr Ser Cys Glu Ala Phe Leu Tyr Lys Ser Leu Pro Leu Trp Asp Gly
        435                 440                 445             
Leu Ser Cys Arg Ser Gln Phe Leu Gln Leu Val Ser Trp Ile Pro Phe
    450                 455                 460                 
Ser Ser Phe Ser Glu Val Lys Pro Leu Leu Phe Asp His Leu Ala Gln
465                 470                 475                 480 
Leu Phe Phe Thr Ser Thr Ile Tyr Phe Lys Cys Ser Val Leu Gln Ser
                485                 490                 495     
Leu Lys Glu Leu Leu Gln Asn Trp Leu Leu Trp Leu Ser Met Asp Ile
            500                 505                 510         
His Met Lys Pro Val Thr Asn Ser Pro Leu Glu Thr Thr Leu Gly Gly
        515                 520                 525             
Ser Met Asn Cys Val Ser Lys Leu Ile His Tyr Val Gly Trp Leu Ser
    530                 535                 540                 
Thr Thr Ala Met Arg Leu Glu Ser Asn Asn Thr Phe Leu Leu His Phe
545                 550                 555                 560 
Ile Leu Asp Phe Tyr Glu Lys Val Cys Asp Ile Tyr Ile Asn Tyr Asp
                565                 570                 575     
Leu Pro Leu Val Val Leu Phe Pro Pro Gly Ile Phe Tyr Ser Ala Leu
            580                 585                 590         
Leu Ser Leu Asp Thr Ser Ile Leu Asn Gln Leu Cys Phe Ile Met His
        595                 600                 605             
Arg Tyr Arg Lys Asn Leu Thr Ala Ala Lys Lys Asn Glu Leu Val Gln
    610                 615                 620                 
Lys Thr Lys Ser Glu Phe Asn Phe Ser Ser Lys Thr Tyr Gln Glu Phe
625                 630                 635                 640 
Asn Tyr Tyr Leu Thr Ser Met Val Gly Cys Leu Trp Thr Ser Lys Pro
                645                 650                 655     
Phe Ala Lys Gly Ile Tyr Ile Asp Pro Glu Ile Leu Glu Lys Thr Gly
            660                 665                 670         
Val Ala Glu Tyr Lys Asn Ser Leu Asn Val Val His His Pro Ser Phe
        675                 680                 685             
Leu Ser Tyr Ala Val Ser Phe Leu Leu Gln Glu Ser Pro Glu Glu Arg
    690                 695                 700                 
Thr Val Asn Val Ser Ser Ile Arg Gly Lys Lys Trp Ser Trp Tyr Leu
705                 710                 715                 720 
Asp Tyr Leu Phe Ser Gln Gly Leu Gln Gly Leu Lys Leu Phe Ile Arg
                725                 730                 735     
Ser Ser Val His His Ser Ser Ile Pro Arg Ala Glu Gly Ile Asn Cys
            740                 745                 750         
Asn Asn Gln Tyr
        755     


<210> 7888
<211> 2612
<212> PRT
<213> Homo sapiens

<400> 7888
Met Ala Asp Val Asp Pro Asp Thr Leu Leu Glu Trp Leu Gln Met Gly
 1               5                  10                  15      
Gln Gly Asp Glu Arg Asp Met Gln Leu Ile Ala Leu Glu Gln Leu Cys
            20                  25                  30          
Met Leu Leu Leu Met Ser Asp Asn Val Asp Arg Cys Phe Glu Thr Cys
        35                  40                  45              
Pro Pro Arg Thr Phe Leu Pro Ala Leu Cys Lys Ile Phe Leu Asp Glu
    50                  55                  60                  
Ser Ala Pro Asp Asn Val Leu Glu Val Thr Ala Arg Ala Ile Thr Tyr
65                  70                  75                  80  
Tyr Leu Asp Val Ser Ala Glu Cys Thr Arg Arg Ile Val Gly Val Asp
                85                  90                  95      
Gly Ala Ile Lys Ala Leu Cys Asn Arg Leu Val Val Val Glu Leu Asn
            100                 105                 110         
Asn Arg Thr Ser Arg Asp Leu Ala Glu Gln Cys Val Lys Val Leu Glu
        115                 120                 125             
Leu Ile Cys Thr Arg Glu Ser Gly Ala Val Phe Glu Ala Gly Gly Leu
    130                 135                 140                 
Asn Cys Val Leu Thr Phe Ile Arg Asp Ser Gly His Leu Val His Lys
145                 150                 155                 160 
Asp Thr Leu His Ser Ala Met Ala Val Val Ser Arg Leu Cys Gly Lys
                165                 170                 175     
Met Glu Pro Gln Asp Ser Ser Leu Glu Ile Cys Val Glu Ser Leu Ser
            180                 185                 190         
Ser Leu Leu Lys His Glu Asp His Gln Val Ser Asp Gly Ala Leu Arg
        195                 200                 205             
Cys Phe Ala Ser Leu Ala Asp Arg Phe Thr Arg Arg Gly Val Asp Pro
    210                 215                 220                 
Ala Pro Leu Ala Lys His Gly Leu Thr Glu Glu Leu Leu Ser Arg Met
225                 230                 235                 240 
Ala Ala Ala Gly Gly Thr Val Ser Gly Pro Ser Ser Ala Cys Lys Pro
                245                 250                 255     
Gly Arg Ser Thr Thr Gly Ala Pro Ser Thr Thr Ala Asp Ser Lys Leu
            260                 265                 270         
Ser Asn Gln Val Ser Thr Ile Val Ser Leu Leu Ser Thr Leu Cys Arg
        275                 280                 285             
Gly Ser Pro Val Val Thr His Asp Leu Leu Arg Ser Glu Leu Pro Asp
    290                 295                 300                 
Ser Ile Glu Ser Ala Leu Gln Gly Asp Glu Arg Cys Val Leu Asp Thr
305                 310                 315                 320 
Met Arg Leu Val Asp Leu Leu Leu Val Leu Leu Phe Glu Gly Arg Lys
                325                 330                 335     
Ala Leu Pro Lys Ser Ser Ala Gly Ser Thr Gly Arg Ile Pro Gly Leu
            340                 345                 350         
Arg Arg Leu Asp Ser Ser Gly Glu Arg Ser His Arg Gln Leu Ile Asp
        355                 360                 365             
Cys Ile Arg Ser Lys Asp Thr Asp Ala Leu Ile Asp Ala Ile Asp Thr
    370                 375                 380                 
Gly Ala Phe Glu Val Asn Phe Met Asp Asp Val Gly Gln Thr Leu Leu
385                 390                 395                 400 
Asn Trp Ala Ser Ala Phe Gly Thr Gln Glu Met Val Glu Phe Leu Cys
                405                 410                 415     
Glu Arg Gly Ala Asp Val Asn Arg Gly Gln Arg Ser Ser Ser Leu His
            420                 425                 430         
Tyr Ala Ala Cys Phe Gly Arg Pro Gln Val Ala Lys Thr Leu Leu Arg
        435                 440                 445             
His Gly Ala Asn Pro Asp Leu Arg Asp Glu Asp Gly Lys Thr Pro Leu
    450                 455                 460                 
Asp Lys Ala Arg Glu Arg Gly His Ser Glu Val Val Ala Ile Leu Gln
465                 470                 475                 480 
Ser Pro Gly Asp Trp Met Cys Pro Val Asn Lys Gly Asp Asp Lys Lys
                485                 490                 495     
Lys Lys Asp Thr Asn Lys Asp Glu Glu Glu Cys Asn Glu Pro Lys Gly
            500                 505                 510         
Asp Pro Glu Met Ala Pro Ile Tyr Leu Lys Arg Leu Leu Pro Val Phe
        515                 520                 525             
Ala Gln Thr Phe Gln Gln Thr Met Leu Pro Ser Ile Arg Lys Ala Ser
    530                 535                 540                 
Leu Ala Leu Ile Arg Lys Met Ile His Phe Cys Ser Glu Ala Leu Leu
545                 550                 555                 560 
Gln Glu Val Cys Asp Ser Asp Val Gly His Asn Leu Pro Thr Ile Leu
                565                 570                 575     
Val Glu Ile Thr Ala Thr Val Leu Asp Gln Glu Asp Asp Asp Asp Gly
            580                 585                 590         
His Leu Leu Ala Leu Gln Ile Ile Arg Asp Ile Val Asp Lys Gly Gly
        595                 600                 605             
Asp Ile Tyr Lys His Gln Leu Ala Arg Leu Gly Val Ile Ser Lys Val
    610                 615                 620                 
Ser Thr Leu Ala Gly Pro Ser Ser Asp Asp Glu Asn Glu Glu Glu Ser
625                 630                 635                 640 
Lys Pro Glu Lys Glu Asp Glu Pro Gln Glu Asp Ala Gln Glu Leu Gln
                645                 650                 655     
Gln Gly Lys Pro Tyr His Trp Arg Asp Trp Ser Ile Ile Arg Gly Arg
            660                 665                 670         
Asp Cys Leu Tyr Ile Trp Ser Asp Ala Ala Ala Leu Glu Leu Ser Asn
        675                 680                 685             
Gly Ser Asn Gly Trp Phe Arg Phe Ile Leu Asp Gly Lys Leu Ala Thr
    690                 695                 700                 
Met Tyr Ser Ser Gly Ser Pro Glu Gly Gly Ser Asp Ser Ser Glu Ser
705                 710                 715                 720 
Arg Ser Glu Phe Leu Glu Lys Leu Gln Arg Ala Arg Gly Gln Val Lys
                725                 730                 735     
Pro Ser Thr Ser Ser Gln Pro Ile Leu Ser Ala Pro Gly Pro Thr Lys
            740                 745                 750         
Leu Thr Val Gly Asn Trp Ser Leu Thr Cys Leu Lys Glu Gly Glu Ile
        755                 760                 765             
Ala Ile His Asn Ser Asp Gly Gln Gln Ala Thr Ile Leu Lys Glu Asp
    770                 775                 780                 
Leu Pro Gly Phe Val Phe Glu Ser Asn Arg Gly Thr Lys His Ser Phe
785                 790                 795                 800 
Thr Ala Glu Thr Ser Leu Gly Ser Glu Phe Val Thr Gly Trp Thr Gly
                805                 810                 815     
Lys Arg Gly Arg Lys Leu Lys Ser Lys Leu Glu Lys Thr Lys Gln Lys
            820                 825                 830         
Val Arg Thr Met Ala Arg Asp Leu Tyr Asp Asp His Phe Lys Ala Val
        835                 840                 845             
Glu Ser Met Pro Arg Gly Val Val Val Thr Leu Arg Asn Ile Ala Thr
    850                 855                 860                 
Gln Leu Glu Ser Ser Trp Glu Leu His Thr Asn Arg Gln Cys Ile Glu
865                 870                 875                 880 
Ser Glu Asn Thr Trp Arg Asp Leu Met Lys Thr Ala Leu Lys Asn Leu
                885                 890                 895     
Ile Val Leu Leu Lys Asp Glu Asn Thr Ile Ser Pro Tyr Glu Met Cys
            900                 905                 910         
Ser Ser Gly Leu Val Gln Ala Leu Leu Thr Val Leu Asn Asn Val Ser
        915                 920                 925             
Ile Phe Arg Ala Thr Lys Gln Lys Gln Asn Glu Val Pro Lys Val Ile
    930                 935                 940                 
Leu Ser Val Phe Lys Thr Ala Phe Thr Glu Asn Glu Asp Asp Glu Ser
945                 950                 955                 960 
Arg Pro Ala Val Ala Leu Ile Arg Lys Leu Ile Ala Val Leu Glu Ser
                965                 970                 975     
Ile Glu Arg Leu Pro Leu His Leu Tyr Asp Thr Pro Gly Ser Thr Tyr
            980                 985                 990         
Asn Leu Gln Ile Leu Thr Arg Arg Leu Arg Phe Arg Leu Glu Arg Ala
        995                 1000                1005            
Pro Gly Glu Thr Ala Leu Ile Asp Arg Thr Gly Arg Met Leu Lys Met
    1010                1015                1020                
Glu Pro Leu Ala Thr Val Glu Ser Leu Glu Gln Tyr Leu Leu Lys Met
1025                1030                1035                1040
Val Ala Lys Gln Trp Tyr Asp Phe Asp Arg Ser Ser Phe Val Phe Val
                1045                1050                1055    
Arg Lys Leu Arg Glu Gly Gln Asn Phe Ile Phe Arg His Gln His Asp
            1060                1065                1070        
Phe Asp Glu Asn Gly Ile Ile Tyr Trp Ile Gly Thr Asn Ala Lys Thr
        1075                1080                1085            
Ala Tyr Glu Trp Val Asn Pro Ala Ala Tyr Gly Leu Val Val Val Thr
    1090                1095                1100                
Ser Ser Glu Gly Arg Asn Leu Pro Tyr Gly Arg Leu Glu Asp Ile Leu
1105                1110                1115                1120
Ser Arg Asp Asn Ser Ala Leu Asn Cys His Ser Asn Asp Asp Lys Asn
                1125                1130                1135    
Ala Trp Phe Ala Ile Asp Leu Gly Leu Trp Val Ile Pro Ser Ala Tyr
            1140                1145                1150        
Thr Leu Arg His Ala Arg Gly Tyr Gly Arg Ser Ala Leu Arg Asn Trp
        1155                1160                1165            
Val Phe Gln Val Ser Lys Asp Gly Gln Asn Trp Thr Ser Leu Tyr Thr
    1170                1175                1180                
His Val Asp Asp Cys Ser Leu Asn Glu Pro Gly Ser Thr Ala Thr Trp
1185                1190                1195                1200
Pro Leu Asp Pro Pro Lys Asp Glu Lys Gln Gly Trp Arg His Val Arg
                1205                1210                1215    
Ile Lys Gln Met Gly Lys Asn Ala Ser Gly Gln Thr His Tyr Leu Ser
            1220                1225                1230        
Leu Ser Gly Phe Glu Leu Tyr Gly Thr Val Asn Gly Val Cys Glu Asp
        1235                1240                1245            
Gln Leu Gly Lys Ala Ala Lys Glu Ala Glu Ala Asn Leu Arg Arg Gln
    1250                1255                1260                
Arg Arg Leu Val Arg Ser Gln Val Leu Lys Tyr Met Val Pro Gly Ala
1265                1270                1275                1280
Arg Val Ile Arg Gly Leu Asp Trp Lys Trp Arg Asp Gln Asp Gly Ser
                1285                1290                1295    
Pro Gln Gly Glu Gly Thr Val Thr Gly Glu Leu His Asn Gly Trp Ile
            1300                1305                1310        
Asp Val Thr Trp Asp Ala Gly Gly Ser Asn Ser Tyr Arg Met Gly Ala
        1315                1320                1325            
Glu Gly Lys Phe Asp Leu Lys Leu Ala Pro Gly Tyr Asp Pro Asp Thr
    1330                1335                1340                
Val Ala Ser Pro Lys Pro Val Ser Ser Thr Val Ser Gly Thr Thr Gln
1345                1350                1355                1360
Ser Trp Ser Ser Leu Val Lys Asn Asn Cys Pro Asp Lys Thr Ser Ala
                1365                1370                1375    
Ala Ala Gly Ser Ser Ser Arg Lys Gly Ser Ser Ser Ser Val Cys Ser
            1380                1385                1390        
Val Ala Ser Ser Ser Asp Ile Ser Leu Gly Ser Thr Lys Thr Glu Arg
        1395                1400                1405            
Arg Ser Glu Ile Val Met Glu His Ser Ile Val Ser Gly Ala Asp Val
    1410                1415                1420                
His Glu Pro Ile Val Val Leu Ser Ser Ala Glu Asn Val Pro Gln Thr
1425                1430                1435                1440
Glu Val Gly Ser Ser Ser Ser Ala Ser Thr Ser Thr Leu Thr Ala Glu
                1445                1450                1455    
Thr Gly Ser Glu Asn Ala Glu Arg Lys Leu Gly Pro Asp Ser Ser Val
            1460                1465                1470        
Arg Thr Pro Gly Glu Ser Ser Ala Ile Ser Met Gly Ile Val Ser Val
        1475                1480                1485            
Ser Ser Pro Asp Val Ser Ser Val Ser Glu Leu Thr Asn Lys Glu Ala
    1490                1495                1500                
Ala Ser Gln Arg Pro Leu Ser Ser Ser Ala Ser Asn Arg Leu Ser Val
1505                1510                1515                1520
Ser Ser Leu Leu Ala Ala Gly Ala Pro Met Ser Ser Ser Ala Ser Val
                1525                1530                1535    
Pro Asn Leu Ser Ser Arg Glu Thr Ser Ser Leu Glu Ser Phe Val Arg
            1540                1545                1550        
Arg Val Ala Asn Ile Ala Arg Thr Asn Ala Thr Asn Asn Met Asn Leu
        1555                1560                1565            
Ser Arg Ser Ser Ser Asp Asn Asn Thr Asn Thr Leu Gly Arg Asn Val
    1570                1575                1580                
Met Ser Thr Ala Thr Ser Pro Leu Met Gly Ala Gln Ser Phe Pro Asn
1585                1590                1595                1600
Leu Thr Thr Pro Gly Thr Thr Ser Thr Val Thr Met Ser Thr Ser Ser
                1605                1610                1615    
Val Thr Ser Ser Ser Asn Val Ala Thr Ala Thr Thr Val Leu Ser Val
            1620                1625                1630        
Gly Gln Ser Leu Ser Asn Thr Leu Thr Thr Ser Leu Thr Ser Thr Ser
        1635                1640                1645            
Ser Glu Ser Asp Thr Gly Gln Glu Ala Glu Tyr Ser Leu Tyr Asp Phe
    1650                1655                1660                
Leu Asp Ser Cys Arg Ala Ser Thr Leu Leu Ala Glu Leu Asp Asp Asp
1665                1670                1675                1680
Glu Asp Leu Pro Glu Pro Asp Glu Glu Asp Asp Glu Asn Glu Asp Asp
                1685                1690                1695    
Asn Gln Glu Asp Gln Glu Tyr Glu Glu Val Met Ile Leu Arg Arg Pro
            1700                1705                1710        
Ser Leu Gln Arg Arg Ala Gly Ser Arg Ser Asp Val Thr His His Ala
        1715                1720                1725            
Val Thr Ser Gln Leu Pro Gln Val Pro Ala Gly Ala Gly Ser Arg Pro
    1730                1735                1740                
Ile Gly Glu Gln Glu Glu Glu Glu Tyr Glu Thr Lys Gly Gly Arg Arg
1745                1750                1755                1760
Arg Thr Trp Asp Asp Asp Tyr Val Leu Lys Arg Gln Phe Ser Ala Leu
                1765                1770                1775    
Val Pro Ala Phe Asp Pro Arg Pro Gly Arg Thr Asn Val Gln Gln Thr
            1780                1785                1790        
Thr Asp Leu Glu Ile Pro Pro Pro Gly Thr Pro His Ser Glu Leu Leu
        1795                1800                1805            
Glu Glu Val Glu Cys Thr Pro Ser Pro Arg Leu Ala Leu Thr Leu Lys
    1810                1815                1820                
Val Thr Gly Leu Gly Thr Thr Arg Glu Val Glu Leu Pro Leu Thr Asn
1825                1830                1835                1840
Phe Arg Ser Thr Ile Phe Tyr Tyr Val Gln Lys Leu Leu Gln Leu Ser
                1845                1850                1855    
Cys Asn Gly Asn Val Lys Ser Asp Lys Leu Arg Arg Ile Trp Glu Pro
            1860                1865                1870        
Thr Tyr Thr Ile Met Tyr Arg Glu Met Lys Asp Ser Asp Lys Glu Lys
        1875                1880                1885            
Glu Asn Gly Lys Met Gly Cys Trp Ser Ile Glu His Val Glu Gln Tyr
    1890                1895                1900                
Leu Gly Thr Asp Glu Leu Pro Lys Asn Asp Leu Ile Thr Tyr Leu Gln
1905                1910                1915                1920
Lys Asn Ala Asp Ala Ala Phe Leu Arg His Trp Lys Leu Thr Gly Thr
                1925                1930                1935    
Asn Lys Ser Ile Arg Lys Asn Arg Asn Cys Ser Gln Leu Ile Ala Ala
            1940                1945                1950        
Tyr Lys Asp Phe Cys Glu His Gly Thr Lys Ser Gly Leu Asn Gln Gly
        1955                1960                1965            
Ala Ile Ser Thr Leu Gln Ser Ser Asp Ile Leu Asn Leu Thr Lys Glu
    1970                1975                1980                
Gln Pro Gln Ala Lys Ala Gly Asn Gly Gln Asn Ser Cys Gly Val Glu
1985                1990                1995                2000
Asp Val Leu Gln Leu Leu Arg Ile Leu Tyr Ile Val Ala Ser Asp Pro
                2005                2010                2015    
Tyr Ser Arg Ile Ser Gln Glu Asp Gly Asp Glu Gln Leu Gln Phe Thr
            2020                2025                2030        
Phe Pro Pro Asp Glu Phe Thr Ser Lys Lys Ile Thr Thr Lys Ile Leu
        2035                2040                2045            
Gln Gln Ile Glu Glu Pro Leu Ala Leu Ala Ser Gly Ala Leu Pro Asp
    2050                2055                2060                
Trp Cys Glu Gln Leu Thr Ser Lys Cys Pro Phe Leu Ile Pro Phe Glu
2065                2070                2075                2080
Thr Arg Gln Leu Tyr Phe Thr Cys Thr Ala Phe Gly Ala Ser Arg Ala
                2085                2090                2095    
Ile Val Trp Leu Gln Asn Arg Arg Glu Ala Thr Val Glu Arg Thr Arg
            2100                2105                2110        
Thr Thr Ser Ser Val Arg Arg Asp Asp Pro Gly Glu Phe Arg Val Gly
        2115                2120                2125            
Arg Leu Lys His Glu Arg Val Lys Val Pro Arg Gly Glu Ser Leu Met
    2130                2135                2140                
Glu Trp Ala Glu Asn Val Met Gln Ile His Ala Asp Arg Lys Ser Val
2145                2150                2155                2160
Leu Glu Val Glu Phe Leu Gly Glu Glu Gly Thr Gly Leu Gly Pro Thr
                2165                2170                2175    
Leu Glu Phe Tyr Ala Leu Val Ala Ala Glu Phe Gln Arg Thr Asp Leu
            2180                2185                2190        
Gly Ala Trp Leu Cys Asp Asp Asn Phe Pro Asp Asp Glu Ser Arg His
        2195                2200                2205            
Val Asp Leu Gly Gly Gly Leu Lys Pro Pro Gly Tyr Tyr Val Gln Arg
    2210                2215                2220                
Ser Cys Gly Leu Phe Thr Ala Pro Phe Pro Gln Asp Ser Asp Glu Leu
2225                2230                2235                2240
Glu Arg Ile Thr Lys Leu Phe His Phe Leu Gly Ile Phe Leu Ala Lys
                2245                2250                2255    
Cys Ile Gln Asp Asn Arg Leu Val Asp Leu Pro Ile Ser Lys Pro Phe
            2260                2265                2270        
Phe Lys Leu Met Cys Met Gly Asp Ile Lys Ser Asn Met Ser Lys Leu
        2275                2280                2285            
Ile Tyr Glu Ser Arg Gly Asp Arg Asp Leu His Cys Thr Glu Ser Gln
    2290                2295                2300                
Ser Glu Ala Ser Thr Glu Glu Gly His Asp Ser Leu Ser Val Gly Ser
2305                2310                2315                2320
Phe Glu Glu Asp Ser Lys Ser Glu Phe Ile Leu Asp Pro Pro Lys Pro
                2325                2330                2335    
Lys Pro Pro Ala Trp Phe Asn Gly Ile Leu Thr Trp Glu Asp Phe Glu
            2340                2345                2350        
Leu Val Asn Pro His Arg Ala Arg Phe Leu Lys Glu Ile Lys Asp Leu
        2355                2360                2365            
Ala Ile Lys Arg Arg Gln Ile Leu Ser Asn Lys Gly Leu Ser Glu Asp
    2370                2375                2380                
Glu Lys Asn Thr Lys Leu Gln Glu Leu Val Leu Lys Asn Pro Ser Gly
2385                2390                2395                2400
Ser Gly Pro Pro Leu Ser Ile Glu Asp Leu Gly Leu Asn Phe Gln Phe
                2405                2410                2415    
Cys Pro Ser Ser Arg Ile Tyr Gly Phe Thr Ala Val Asp Leu Lys Pro
            2420                2425                2430        
Ser Gly Glu Asp Glu Met Ile Thr Met Asp Asn Ala Glu Glu Tyr Val
        2435                2440                2445            
Asp Leu Met Phe Asp Phe Cys Met His Thr Gly Ile Gln Lys Gln Met
    2450                2455                2460                
Glu Ala Phe Arg Asp Gly Phe Asn Lys Val Phe Pro Met Glu Lys Leu
2465                2470                2475                2480
Ser Ser Phe Ser His Glu Glu Val Gln Met Ile Leu Cys Gly Asn Gln
                2485                2490                2495    
Ser Pro Ser Trp Ala Ala Glu Asp Ile Ile Asn Tyr Thr Glu Pro Lys
            2500                2505                2510        
Leu Gly Tyr Thr Arg Asp Ser Pro Gly Phe Leu Arg Phe Val Arg Val
        2515                2520                2525            
Leu Cys Gly Met Ser Ser Asp Glu Arg Lys Ala Phe Leu Gln Phe Thr
    2530                2535                2540                
Thr Gly Cys Ser Thr Leu Pro Pro Gly Gly Leu Ala Asn Leu His Pro
2545                2550                2555                2560
Arg Leu Thr Val Val Arg Lys Val Asp Ala Thr Asp Ala Ser Tyr Pro
                2565                2570                2575    
Ser Val Asn Thr Cys Val His Tyr Leu Lys Leu Pro Glu Tyr Ser Ser
            2580                2585                2590        
Glu Glu Ile Met Arg Glu Arg Leu Leu Ala Ala Thr Met Glu Lys Gly
        2595                2600                2605            
Phe His Leu Asn
    2610        


<210> 7889
<211> 722
<212> PRT
<213> Homo sapiens

<400> 7889
Met His Leu Asn Thr Leu Ala Gly Arg Ser Tyr Asn Asp Leu Met Gln
 1               5                  10                  15      
Tyr Pro Val Phe Pro Trp Ile Leu Ala Asp Tyr Asp Ser Glu Glu Val
            20                  25                  30          
Asp Leu Thr Asn Pro Lys Thr Phe Arg Asn Leu Ala Lys Pro Met Gly
        35                  40                  45              
Ala Gln Thr Asp Glu Arg Leu Ala Gln Tyr Lys Lys Arg Tyr Lys Asp
    50                  55                  60                  
Trp Glu Asp Pro Asn Gly Glu Thr Pro Ala Tyr His Tyr Gly Thr His
65                  70                  75                  80  
Tyr Ser Ser Ala Met Ile Val Ala Ser Tyr Leu Val Arg Met Glu Pro
                85                  90                  95      
Phe Thr Gln Ile Phe Leu Arg Leu Gln Gly Gly His Phe Asp Leu Ala
            100                 105                 110         
Asp Arg Met Phe His Ser Val Arg Glu Ala Trp Tyr Ser Ala Ser Lys
        115                 120                 125             
His Asn Met Ala Asp Val Lys Glu Leu Ile Pro Glu Phe Phe Tyr Leu
    130                 135                 140                 
Pro Glu Phe Leu Phe Asn Ser Asn Asn Phe Asp Leu Gly Cys Lys Gln
145                 150                 155                 160 
Asn Gly Thr Lys Leu Gly Asp Val Ile Leu Pro Pro Trp Ala Lys Gly
                165                 170                 175     
Asp Pro Arg Glu Phe Ile Arg Val His Arg Glu Ala Leu Glu Cys Asp
            180                 185                 190         
Tyr Val Ser Ala His Leu His Glu Trp Ile Asp Leu Ile Phe Gly Tyr
        195                 200                 205             
Lys Gln Gln Gly Pro Ala Ala Val Glu Ala Val Asn Val Phe His His
    210                 215                 220                 
Leu Phe Tyr Glu Gly Gln Val Asp Ile Tyr Asn Ile Asn Asp Pro Leu
225                 230                 235                 240 
Lys Glu Thr Ala Thr Ile Gly Phe Ile Asn Asn Phe Gly Gln Ile Pro
                245                 250                 255     
Lys Gln Leu Phe Lys Lys Pro His Pro Pro Lys Arg Val Arg Ser Arg
            260                 265                 270         
Leu Asn Gly Asp Asn Ala Gly Ile Ser Val Leu Pro Gly Ser Thr Ser
        275                 280                 285             
Asp Lys Ile Phe Phe His His Leu Asp Asn Leu Arg Pro Ser Leu Thr
    290                 295                 300                 
Pro Val Lys Glu Leu Lys Glu Pro Val Gly Gln Ile Val Cys Thr Asp
305                 310                 315                 320 
Lys Gly Ile Leu Ala Val Glu Gln Asn Lys Val Leu Ile Pro Pro Thr
                325                 330                 335     
Trp Asn Lys Thr Phe Ala Trp Gly Tyr Ala Asp Leu Ser Cys Arg Leu
            340                 345                 350         
Gly Thr Tyr Glu Ser Asp Lys Ala Met Thr Val Tyr Glu Cys Leu Ser
        355                 360                 365             
Glu Trp Gly Gln Ile Leu Cys Ala Ile Cys Pro Asn Pro Lys Leu Val
    370                 375                 380                 
Ile Thr Gly Gly Thr Ser Thr Val Val Cys Val Trp Glu Met Gly Thr
385                 390                 395                 400 
Ser Lys Glu Lys Ala Lys Thr Val Thr Leu Lys Gln Ala Leu Leu Gly
                405                 410                 415     
His Thr Asp Thr Val Thr Cys Ala Thr Ala Ser Leu Ala Tyr His Ile
            420                 425                 430         
Ile Val Ser Gly Ser Arg Asp Arg Thr Cys Ile Ile Trp Asp Leu Asn
        435                 440                 445             
Lys Leu Ser Phe Leu Thr Gln Leu Arg Gly His Arg Ala Pro Val Ser
    450                 455                 460                 
Ala Leu Cys Ile Asn Glu Leu Thr Gly Asp Ile Val Ser Cys Ala Gly
465                 470                 475                 480 
Thr Tyr Ile His Val Trp Ser Ile Asn Gly Asn Pro Ile Val Ser Val
                485                 490                 495     
Asn Thr Phe Thr Gly Arg Ser Gln Gln Ile Ile Cys Cys Cys Met Ser
            500                 505                 510         
Glu Met Asn Glu Trp Asp Thr Gln Asn Val Ile Val Thr Gly His Ser
        515                 520                 525             
Asp Gly Val Val Arg Phe Trp Arg Met Glu Phe Leu Gln Val Pro Glu
    530                 535                 540                 
Thr Pro Ala Pro Glu Pro Ala Glu Val Leu Glu Met Gln Gly Pro Leu
545                 550                 555                 560 
Ser His Pro His Pro Asn Pro Ile Glu Val Arg Asn Tyr Ser Arg Leu
                565                 570                 575     
Lys Pro Gly Tyr Arg Trp Glu Arg Gln Leu Val Phe Arg Ser Lys Pro
            580                 585                 590         
Thr Met His Thr Ala Phe Asp Arg Lys Asp Asn Ala His Pro Ala Glu
        595                 600                 605             
Val Thr Ala Leu Gly Ile Ser Lys Asp His Ser Arg Ile Leu Val Gly
    610                 615                 620                 
Asp Ser Arg Gly Arg Val Phe Ser Trp Ser Val Ser Asp Gln Pro Gly
625                 630                 635                 640 
Arg Ser Ala Ala Asp His Trp Val Lys Asp Glu Gly Gly Asp Ser Cys
                645                 650                 655     
Ser Gly Cys Ser Val Arg Phe Ser Leu Thr Glu Arg Arg His His Cys
            660                 665                 670         
Arg Asn Cys Gly Gln Leu Phe Cys Gln Lys Cys Ser Arg Phe Gln Ser
        675                 680                 685             
Glu Ile Lys Arg Leu Lys Ile Ser Ser Pro Val Arg Val Cys Gln Asn
    690                 695                 700                 
Cys Tyr Tyr Asn Leu Gln His Glu Arg Gly Ser Glu Asp Gly Pro Arg
705                 710                 715                 720 
Asn Cys
        


<210> 7890
<211> 636
<212> PRT
<213> Homo sapiens

<400> 7890
Met Val Arg Asn Asp Met Phe Tyr Asn His Tyr Pro Tyr Val Pro Glu
 1               5                  10                  15      
Thr Glu Gln Glu Thr Asn Val Ala Lys Pro Ala Arg Tyr Arg Arg Ala
            20                  25                  30          
Val Ser Tyr Asp Ser Lys Glu Tyr Tyr Met Arg Leu Ala Ser Gly Asn
        35                  40                  45              
Pro Ala Ile Val Gln Asp Ala Ile Val Glu Ser Ser Glu Gly Glu Ala
    50                  55                  60                  
Ala Gln Gln Glu Pro Glu His Gly Glu Asp Thr Ile Ala Lys Val Lys
65                  70                  75                  80  
Gly Leu Val Lys Pro Pro Leu Lys Arg Ser Arg Ser Ala Pro Asp Gly
                85                  90                  95      
Gly Asp Glu Glu Asn Gln Glu Gln Leu Gln Asp Gln Ile Ala Glu Gly
            100                 105                 110         
Ser Ser Ile Glu Glu Glu Glu Lys Thr Asp Asn Ala Thr Leu Leu Arg
        115                 120                 125             
Leu Leu Glu Glu Gly Glu Lys Ile Gln His Met Tyr Arg Cys Ala Arg
    130                 135                 140                 
Val Gln Gly Leu Asp Thr Ser Glu Gly Leu Leu Leu Phe Gly Lys Glu
145                 150                 155                 160 
His Phe Tyr Val Ile Asp Gly Phe Thr Met Thr Ala Thr Arg Glu Ile
                165                 170                 175     
Arg Asp Ile Glu Thr Leu Pro Pro Asn Met His Glu Pro Ile Ile Pro
            180                 185                 190         
Arg Gly Ala Arg Gln Gly Pro Ser Gln Leu Lys Arg Thr Cys Ser Ile
        195                 200                 205             
Phe Ala Tyr Glu Asp Ile Lys Glu Val His Lys Arg Arg Tyr Leu Leu
    210                 215                 220                 
Gln Pro Ile Ala Val Glu Val Phe Ser Gly Asp Gly Arg Asn Tyr Leu
225                 230                 235                 240 
Leu Ala Phe Gln Lys Gly Ile Arg Asn Lys Val Tyr Gln Arg Phe Leu
                245                 250                 255     
Ala Val Val Pro Ser Leu Thr Asp Ser Ser Glu Ser Val Ser Gly Gln
            260                 265                 270         
Arg Pro Asn Thr Ser Val Glu Gln Gly Ser Gly Leu Leu Ser Thr Leu
        275                 280                 285             
Val Gly Glu Lys Ser Val Thr Gln Arg Trp Glu Arg Gly Glu Ile Ser
    290                 295                 300                 
Asn Phe Gln Tyr Leu Met His Leu Asn Thr Leu Ala Gly Arg Ser Tyr
305                 310                 315                 320 
Asn Asp Leu Met Gln Tyr Pro Val Phe Pro Trp Ile Leu Ala Asp Tyr
                325                 330                 335     
Asp Ser Glu Glu Val Asp Leu Thr Asn Pro Lys Thr Phe Arg Asn Leu
            340                 345                 350         
Ala Lys Pro Met Gly Ala Gln Thr Asp Glu Arg Leu Ala Gln Tyr Lys
        355                 360                 365             
Lys Arg Tyr Lys Asp Trp Glu Asp Pro Asn Gly Glu Thr Pro Ala Tyr
    370                 375                 380                 
His Tyr Gly Thr His Tyr Ser Ser Ala Met Ile Val Ala Ser Tyr Leu
385                 390                 395                 400 
Val Arg Met Glu Pro Phe Thr Gln Ile Phe Leu Arg Leu Gln Gly Gly
                405                 410                 415     
His Phe Asp Leu Ala Asp Arg Met Phe His Ser Val Arg Glu Ala Trp
            420                 425                 430         
Tyr Ser Ala Ser Lys His Asn Met Ala Asp Val Lys Glu Leu Ile Pro
        435                 440                 445             
Glu Phe Phe Tyr Leu Pro Glu Phe Leu Phe Asn Ser Asn Asn Phe Asp
    450                 455                 460                 
Leu Gly Cys Lys Gln Asn Gly Thr Lys Leu Gly Asp Val Ile Leu Pro
465                 470                 475                 480 
Pro Trp Ala Lys Gly Asp Pro Arg Glu Phe Ile Arg Val His Arg Glu
                485                 490                 495     
Ala Leu Glu Cys Asp Tyr Val Ser Ala His Leu His Glu Trp Ile Asp
            500                 505                 510         
Leu Ile Phe Gly Tyr Lys Gln Gln Gly Pro Ala Ala Val Glu Ala Val
        515                 520                 525             
Asn Val Phe His His Leu Phe Tyr Glu Gly Gln Val Asp Ile Tyr Asn
    530                 535                 540                 
Ile Asn Asp Pro Leu Lys Glu Thr Ala Thr Ile Gly Phe Ile Asn Asn
545                 550                 555                 560 
Phe Gly Gln Ile Pro Lys Gln Leu Phe Lys Lys Pro His Pro Pro Lys
                565                 570                 575     
Arg Val Arg Ser Arg Leu Asn Gly Asp Asn Ala Gly Ile Ser Val Leu
            580                 585                 590         
Pro Gly Ser Thr Ser Asp Lys Ile Phe Phe His His Leu Asp Asn Leu
        595                 600                 605             
Arg Pro Ser Leu Thr Pro Val Lys Glu Leu Lys Glu Pro Val Gly Gln
    610                 615                 620                 
Ile Val Cys Thr Asp Lys Gly Ile Leu Ala Val Glu
625                 630                 635     


<210> 7891
<211> 664
<212> PRT
<213> Homo sapiens

<400> 7891
Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe
 1               5                  10                  15      
Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala
            20                  25                  30          
Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln
        35                  40                  45              
Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp
    50                  55                  60                  
Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser
65                  70                  75                  80  
Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro
                85                  90                  95      
Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His
            100                 105                 110         
Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys
        115                 120                 125             
Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly
    130                 135                 140                 
Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln
145                 150                 155                 160 
Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys
                165                 170                 175     
Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro
            180                 185                 190         
Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg
        195                 200                 205             
Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg
    210                 215                 220                 
Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr
225                 230                 235                 240 
Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly
                245                 250                 255     
Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu
            260                 265                 270         
His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala
        275                 280                 285             
Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln
    290                 295                 300                 
Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys
305                 310                 315                 320 
Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala
                325                 330                 335     
Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln
            340                 345                 350         
Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu
        355                 360                 365             
Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln
    370                 375                 380                 
Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp
385                 390                 395                 400 
Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser
                405                 410                 415     
Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val
            420                 425                 430         
Gln Val Lys Ala Ser Ser Pro Val Pro Ala Thr Pro Ile Leu Gln Leu
        435                 440                 445             
Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln
    450                 455                 460                 
Pro Pro Leu Ser Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp
465                 470                 475                 480 
Asp Gly Asn Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr
                485                 490                 495     
Met Cys Thr Val Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg
            500                 505                 510         
Val Lys Ala Phe Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu
        515                 520                 525             
Val Leu Gln Thr Ser Glu Val Ala Trp Phe Ala Phe Asp Pro Gly Ser
    530                 535                 540                 
Ala His Ser Asp Ile Ile Leu Ser Asn Asp Asn Leu Thr Val Thr Cys
545                 550                 555                 560 
Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Lys Thr Gly Phe Ser Lys
                565                 570                 575     
Gly Ile His Tyr Trp Glu Leu Thr Val Asp Arg Tyr Asp Asn His Pro
            580                 585                 590         
Asp Pro Ala Phe Gly Val Ala Arg Met Asp Val Met Lys Asp Val Met
        595                 600                 605             
Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn Arg
    610                 615                 620                 
Ser Trp Phe Met His Asn Asn Ser His Thr Asn Arg Thr Glu Gly Gly
625                 630                 635                 640 
Ile Thr Lys Gly Ala Thr Ile Gly Val Leu Leu Asp Leu Asn Arg Lys
                645                 650                 655     
Asn Leu Thr Phe Phe Tyr Gln Arg
            660                 


<210> 7892
<211> 802
<212> PRT
<213> Homo sapiens

<400> 7892
Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe
 1               5                  10                  15      
Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala
            20                  25                  30          
Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln
        35                  40                  45              
Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp
    50                  55                  60                  
Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser
65                  70                  75                  80  
Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro
                85                  90                  95      
Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His
            100                 105                 110         
Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys
        115                 120                 125             
Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly
    130                 135                 140                 
Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln
145                 150                 155                 160 
Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys
                165                 170                 175     
Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro
            180                 185                 190         
Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg
        195                 200                 205             
Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg
    210                 215                 220                 
Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr
225                 230                 235                 240 
Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly
                245                 250                 255     
Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu
            260                 265                 270         
His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala
        275                 280                 285             
Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln
    290                 295                 300                 
Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys
305                 310                 315                 320 
Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala
                325                 330                 335     
Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln
            340                 345                 350         
Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu
        355                 360                 365             
Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln
    370                 375                 380                 
Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp
385                 390                 395                 400 
Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser
                405                 410                 415     
Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val
            420                 425                 430         
Gln Val Lys Val Pro Ala Thr Pro Ile Leu Gln Leu Glu Glu Cys Cys
        435                 440                 445             
Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln Pro Pro Leu Ser
    450                 455                 460                 
Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp Asp Gly Asn Gly
465                 470                 475                 480 
Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr Met Cys Thr Val
                485                 490                 495     
Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg Val Lys Ala Phe
            500                 505                 510         
Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu Val Leu Gln Thr
        515                 520                 525             
Ser Glu Asp Thr Asp Ser Glu Glu Gln Thr Leu Pro Phe Pro Val Pro
    530                 535                 540                 
Ser Glu Arg Leu Pro Leu Arg Arg Met Ser Pro Phe Ser Ser Thr Leu
545                 550                 555                 560 
Asn Leu Gln Pro Ser Phe Pro Gly Arg Ser Tyr Phe Asp Phe Arg Ser
                565                 570                 575     
Ser Pro His Gln Leu Ser Leu His Ser Ser Leu Gln Ser Leu Asn Ala
            580                 585                 590         
Pro Gly Cys Asn Phe Glu Thr Gln Ser Ala Pro Tyr Ser Gln Leu Val
        595                 600                 605             
Asp Ile Lys Lys Leu Leu Ala Val Ala Trp Phe Ala Phe Asp Pro Gly
    610                 615                 620                 
Ser Ala His Ser Asp Ile Ile Leu Ser Asn Asp Asn Leu Thr Val Thr
625                 630                 635                 640 
Cys Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Lys Thr Gly Phe Ser
                645                 650                 655     
Lys Gly Ile His Tyr Trp Glu Leu Thr Val Asp Arg Tyr Asp Asn His
            660                 665                 670         
Pro Asp Pro Ala Phe Gly Val Ala Arg Met Asp Val Met Lys Asp Val
        675                 680                 685             
Met Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn
    690                 695                 700                 
Arg Ser Trp Phe Met His Asn Asn Ser His Thr Asn Arg Thr Glu Gly
705                 710                 715                 720 
Gly Ile Thr Lys Gly Ala Thr Ile Gly Val Leu Leu Asp Leu Asn Arg
                725                 730                 735     
Lys Asn Leu Thr Phe Phe Ile Asn Asp Glu Gln Gln Gly Pro Ile Ala
            740                 745                 750         
Phe Asp Asn Val Glu Gly Leu Phe Phe Pro Ala Val Ser Leu Asn Arg
        755                 760                 765             
Asn Val Gln Val Ser Thr Leu Pro Leu Arg Leu Asn Ser Cys Cys Trp
    770                 775                 780                 
Leu Pro Val Gln Arg Leu Pro Arg Ala Val Gln Ser Asn Arg Arg Glu
785                 790                 795                 800 
Gly Ser
        


<210> 7893
<211> 710
<212> PRT
<213> Homo sapiens

<400> 7893
Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe
 1               5                  10                  15      
Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala
            20                  25                  30          
Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln
        35                  40                  45              
Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp
    50                  55                  60                  
Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser
65                  70                  75                  80  
Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro
                85                  90                  95      
Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His
            100                 105                 110         
Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys
        115                 120                 125             
Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly
    130                 135                 140                 
Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln
145                 150                 155                 160 
Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys
                165                 170                 175     
Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro
            180                 185                 190         
Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg
        195                 200                 205             
Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg
    210                 215                 220                 
Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr
225                 230                 235                 240 
Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly
                245                 250                 255     
Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu
            260                 265                 270         
His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala
        275                 280                 285             
Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln
    290                 295                 300                 
Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys
305                 310                 315                 320 
Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala
                325                 330                 335     
Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln
            340                 345                 350         
Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu
        355                 360                 365             
Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln
    370                 375                 380                 
Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp
385                 390                 395                 400 
Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser
                405                 410                 415     
Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val
            420                 425                 430         
Gln Val Lys Ala Ser Ser Pro Val Pro Ala Thr Pro Ile Leu Gln Leu
        435                 440                 445             
Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln
    450                 455                 460                 
Pro Pro Leu Ser Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp
465                 470                 475                 480 
Asp Gly Asn Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr
                485                 490                 495     
Met Cys Thr Val Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg
            500                 505                 510         
Val Lys Ala Phe Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu
        515                 520                 525             
Val Leu Gln Thr Ser Glu Val Ala Trp Phe Ala Phe Asp Pro Gly Ser
    530                 535                 540                 
Ala His Ser Asp Ile Ile Leu Ser Asn Asp Asn Leu Thr Val Thr Cys
545                 550                 555                 560 
Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Lys Thr Gly Phe Ser Lys
                565                 570                 575     
Gly Ile His Tyr Trp Glu Leu Thr Val Asp Arg Tyr Asp Asn His Pro
            580                 585                 590         
Asp Pro Ala Phe Gly Val Ala Arg Met Asp Val Met Lys Asp Val Met
        595                 600                 605             
Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn Arg
    610                 615                 620                 
Ser Trp Phe Met His Asn Asn Ser His Thr Asn Arg Thr Glu Gly Gly
625                 630                 635                 640 
Ile Thr Lys Gly Ala Thr Ile Gly Val Leu Leu Asp Leu Asn Arg Lys
                645                 650                 655     
Asn Leu Thr Phe Phe Ile Asn Asp Glu Gln Gln Gly Pro Ile Ala Phe
            660                 665                 670         
Asp Asn Val Glu Gly Leu Phe Phe Pro Ala Val Ser Leu Asn Arg Asn
        675                 680                 685             
Val Gln Val Thr Leu His Thr Gly Leu Pro Val Pro Asp Phe Tyr Ser
    690                 695                 700                 
Ser Arg Ala Ser Ile Ala
705                 710 


<210> 7894
<211> 550
<212> PRT
<213> Homo sapiens

<400> 7894
Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe
 1               5                  10                  15      
Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala
            20                  25                  30          
Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln
        35                  40                  45              
Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp
    50                  55                  60                  
Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser
65                  70                  75                  80  
Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro
                85                  90                  95      
Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His
            100                 105                 110         
Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys
        115                 120                 125             
Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly
    130                 135                 140                 
Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln
145                 150                 155                 160 
Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys
                165                 170                 175     
Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro
            180                 185                 190         
Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg
        195                 200                 205             
Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg
    210                 215                 220                 
Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr
225                 230                 235                 240 
Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly
                245                 250                 255     
Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu
            260                 265                 270         
His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala
        275                 280                 285             
Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln
    290                 295                 300                 
Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys
305                 310                 315                 320 
Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala
                325                 330                 335     
Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln
            340                 345                 350         
Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu
        355                 360                 365             
Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln
    370                 375                 380                 
Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp
385                 390                 395                 400 
Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser
                405                 410                 415     
Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val
            420                 425                 430         
Gln Val Lys Ala Ser Ser Pro Val Pro Ala Thr Pro Ile Leu Gln Leu
        435                 440                 445             
Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln
    450                 455                 460                 
Pro Pro Leu Ser Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp
465                 470                 475                 480 
Asp Gly Asn Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr
                485                 490                 495     
Met Cys Thr Val Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg
            500                 505                 510         
Val Lys Ala Phe Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu
        515                 520                 525             
Val Leu Gln Thr Ser Glu Gly Lys Ala Leu Gln Gln Tyr Pro Ser Glu
    530                 535                 540                 
Arg Glu Leu Arg Gly Ile
545                 550 


<210> 7895
<211> 664
<212> PRT
<213> Homo sapiens

<400> 7895
Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe
 1               5                  10                  15      
Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala
            20                  25                  30          
Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln
        35                  40                  45              
Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp
    50                  55                  60                  
Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser
65                  70                  75                  80  
Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro
                85                  90                  95      
Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His
            100                 105                 110         
Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys
        115                 120                 125             
Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly
    130                 135                 140                 
Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln
145                 150                 155                 160 
Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys
                165                 170                 175     
Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro
            180                 185                 190         
Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg
        195                 200                 205             
Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg
    210                 215                 220                 
Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr
225                 230                 235                 240 
Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly
                245                 250                 255     
Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu
            260                 265                 270         
His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala
        275                 280                 285             
Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln
    290                 295                 300                 
Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys
305                 310                 315                 320 
Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala
                325                 330                 335     
Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln
            340                 345                 350         
Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu
        355                 360                 365             
Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln
    370                 375                 380                 
Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp
385                 390                 395                 400 
Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser
                405                 410                 415     
Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val
            420                 425                 430         
Gln Val Lys Ala Ser Ser Pro Val Pro Ala Thr Pro Ile Leu Gln Leu
        435                 440                 445             
Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln
    450                 455                 460                 
Pro Pro Leu Ser Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp
465                 470                 475                 480 
Asp Gly Asn Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr
                485                 490                 495     
Met Cys Thr Val Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg
            500                 505                 510         
Val Lys Ala Phe Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu
        515                 520                 525             
Val Leu Gln Thr Ser Glu Val Ala Trp Phe Ala Phe Asp Pro Gly Ser
    530                 535                 540                 
Ala His Ser Asp Ile Ile Leu Ser Asn Asp Asn Leu Thr Val Thr Cys
545                 550                 555                 560 
Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Lys Thr Gly Phe Ser Lys
                565                 570                 575     
Gly Ile His Tyr Trp Glu Leu Thr Val Asp Arg Tyr Asp Asn His Pro
            580                 585                 590         
Asp Pro Ala Phe Gly Val Ala Arg Met Asp Val Met Lys Asp Val Met
        595                 600                 605             
Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn Arg
    610                 615                 620                 
Ser Trp Phe Met His Asn Asn Ser His Thr Asn Arg Thr Glu Gly Gly
625                 630                 635                 640 
Ile Thr Lys Gly Ala Thr Ile Gly Val Leu Leu Asp Leu Asn Arg Lys
                645                 650                 655     
Lys Leu Asp Ile Phe Tyr Gln Arg
            660                 


<210> 7896
<211> 589
<212> PRT
<213> Homo sapiens

<400> 7896
Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro
 1               5                  10                  15      
Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg
            20                  25                  30          
Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu
        35                  40                  45              
Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr
    50                  55                  60                  
Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser
65                  70                  75                  80  
Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn
                85                  90                  95      
His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu
            100                 105                 110         
Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala
        115                 120                 125             
Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn
    130                 135                 140                 
Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu
145                 150                 155                 160 
Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu
                165                 170                 175     
Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu
            180                 185                 190         
Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly
        195                 200                 205             
Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala
    210                 215                 220                 
Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu
225                 230                 235                 240 
Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys
                245                 250                 255     
Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln
            260                 265                 270         
Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr
        275                 280                 285             
Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val
    290                 295                 300                 
Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp
305                 310                 315                 320 
Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met
                325                 330                 335     
Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly
            340                 345                 350         
Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Leu Val
        355                 360                 365             
Leu Arg Met Leu Glu Tyr Glu Pro Ala Ala Arg Ile Ser Pro Leu Gly
    370                 375                 380                 
Ala Leu Gln His Gly Phe Phe Arg Arg Thr Ala Asp Glu Ala Thr Asn
385                 390                 395                 400 
Thr Gly Pro Ala Gly Ser Ser Ala Ser Thr Ser Pro Ala Pro Leu Asp
                405                 410                 415     
Thr Cys Pro Ser Ser Ser Thr Ala Ser Ser Ile Ser Ser Ser Gly Gly
            420                 425                 430         
Ser Ser Gly Ser Ser Ser Asp Asn Arg Thr Tyr Arg Tyr Ser Asn Arg
        435                 440                 445             
Tyr Cys Gly Gly Pro Gly Pro Pro Ile Thr Asp Cys Glu Met Asn Ser
    450                 455                 460                 
Pro Gln Val Pro Pro Ser Gln Pro Leu Arg Pro Trp Ala Gly Gly Asp
465                 470                 475                 480 
Val Pro His Lys Thr His Gln Ala Pro Ala Ser Ala Ser Ser Leu Pro
                485                 490                 495     
Gly Thr Gly Ala Gln Leu Pro Pro Gln Pro Arg Tyr Leu Gly Arg Pro
            500                 505                 510         
Pro Ser Pro Thr Ser Pro Pro Pro Pro Glu Leu Met Asp Val Ser Leu
        515                 520                 525             
Val Gly Gly Pro Ala Asp Cys Ser Pro Pro His Pro Ala Pro Ala Pro
    530                 535                 540                 
Gln His Pro Ala Ala Ser Ala Leu Arg Thr Arg Met Thr Gly Gly Arg
545                 550                 555                 560 
Pro Pro Leu Pro Pro Pro Asp Asp Pro Ala Thr Leu Gly Pro His Leu
                565                 570                 575     
Gly Leu Arg Gly Val Pro Gln Ser Thr Ala Ala Ser Ser
            580                 585                 


<210> 7897
<211> 629
<212> PRT
<213> Homo sapiens

<400> 7897
Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro
 1               5                  10                  15      
Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg
            20                  25                  30          
Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu
        35                  40                  45              
Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr
    50                  55                  60                  
Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser
65                  70                  75                  80  
Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn
                85                  90                  95      
His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu
            100                 105                 110         
Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala
        115                 120                 125             
Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn
    130                 135                 140                 
Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu
145                 150                 155                 160 
Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu
                165                 170                 175     
Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu
            180                 185                 190         
Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly
        195                 200                 205             
Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala
    210                 215                 220                 
Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu
225                 230                 235                 240 
Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys
                245                 250                 255     
Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln
            260                 265                 270         
Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr
        275                 280                 285             
Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val
    290                 295                 300                 
Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp
305                 310                 315                 320 
Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met
                325                 330                 335     
Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly
            340                 345                 350         
Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Tyr Gln
        355                 360                 365             
Gly Pro Gly Thr Arg Arg Leu Gln Glu Val Leu Gly Val Gln Thr Gly
    370                 375                 380                 
Gly Pro Gly Gly Arg Arg Ala Gly Glu Pro Gly His Ser Pro Ala Asp
385                 390                 395                 400 
Tyr Leu Arg Phe Gln Asp Leu Val Leu Arg Met Leu Glu Tyr Glu Pro
                405                 410                 415     
Ala Ala Arg Ile Ser Pro Leu Gly Ala Leu Gln His Gly Phe Phe Arg
            420                 425                 430         
Arg Thr Ala Asp Glu Ala Thr Asn Thr Gly Pro Ala Gly Ser Ser Ala
        435                 440                 445             
Ser Thr Ser Pro Ala Pro Leu Asp Thr Cys Pro Ser Ser Ser Thr Ala
    450                 455                 460                 
Ser Ser Ile Ser Ser Ser Gly Gly Ser Ser Gly Ser Ser Ser Asp Asn
465                 470                 475                 480 
Arg Thr Tyr Arg Tyr Ser Asn Arg Tyr Cys Gly Gly Pro Gly Pro Pro
                485                 490                 495     
Ile Thr Asp Cys Glu Met Asn Ser Pro Gln Val Pro Pro Ser Gln Pro
            500                 505                 510         
Leu Arg Pro Trp Ala Gly Gly Asp Val Pro His Lys Thr His Gln Ala
        515                 520                 525             
Pro Ala Ser Ala Ser Ser Leu Pro Gly Thr Gly Ala Gln Leu Pro Pro
    530                 535                 540                 
Gln Pro Arg Tyr Leu Gly Arg Pro Pro Ser Pro Thr Ser Pro Pro Pro
545                 550                 555                 560 
Pro Glu Leu Met Asp Val Ser Leu Val Gly Gly Pro Ala Asp Cys Ser
                565                 570                 575     
Pro Pro His Pro Ala Pro Ala Pro Gln His Pro Ala Ala Ser Ala Leu
            580                 585                 590         
Arg Thr Arg Met Thr Gly Gly Arg Pro Pro Leu Pro Pro Pro Asp Asp
        595                 600                 605             
Pro Ala Thr Leu Gly Pro His Leu Gly Leu Arg Gly Val Pro Gln Ser
    610                 615                 620                 
Thr Ala Ala Ser Ser
625                 


<210> 7898
<211> 601
<212> PRT
<213> Homo sapiens

<400> 7898
Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro
 1               5                  10                  15      
Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg
            20                  25                  30          
Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu
        35                  40                  45              
Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr
    50                  55                  60                  
Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser
65                  70                  75                  80  
Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn
                85                  90                  95      
His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu
            100                 105                 110         
Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala
        115                 120                 125             
Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn
    130                 135                 140                 
Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu
145                 150                 155                 160 
Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu
                165                 170                 175     
Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu
            180                 185                 190         
Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly
        195                 200                 205             
Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala
    210                 215                 220                 
Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu
225                 230                 235                 240 
Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys
                245                 250                 255     
Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln
            260                 265                 270         
Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr
        275                 280                 285             
Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val
    290                 295                 300                 
Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp
305                 310                 315                 320 
Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met
                325                 330                 335     
Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly
            340                 345                 350         
Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Tyr Gln
        355                 360                 365             
Gly Pro Gly Thr Arg Arg Leu Gln Glu Asp Leu Val Leu Arg Met Leu
    370                 375                 380                 
Glu Tyr Glu Pro Ala Ala Arg Ile Ser Pro Leu Gly Ala Leu Gln His
385                 390                 395                 400 
Gly Phe Phe Arg Arg Thr Ala Asp Glu Ala Thr Asn Thr Gly Pro Ala
                405                 410                 415     
Gly Ser Ser Ala Ser Thr Ser Pro Ala Pro Leu Asp Thr Cys Pro Ser
            420                 425                 430         
Ser Ser Thr Ala Ser Ser Ile Ser Ser Ser Gly Gly Ser Ser Gly Ser
        435                 440                 445             
Ser Ser Asp Asn Arg Thr Tyr Arg Tyr Ser Asn Arg Tyr Cys Gly Gly
    450                 455                 460                 
Pro Gly Pro Pro Ile Thr Asp Cys Glu Met Asn Ser Pro Gln Val Pro
465                 470                 475                 480 
Pro Ser Gln Pro Leu Arg Pro Trp Ala Gly Gly Asp Val Pro His Lys
                485                 490                 495     
Thr His Gln Ala Pro Ala Ser Ala Ser Ser Leu Pro Gly Thr Gly Ala
            500                 505                 510         
Gln Leu Pro Pro Gln Pro Arg Tyr Leu Gly Arg Pro Pro Ser Pro Thr
        515                 520                 525             
Ser Pro Pro Pro Pro Glu Leu Met Asp Val Ser Leu Val Gly Gly Pro
    530                 535                 540                 
Ala Asp Cys Ser Pro Pro His Pro Ala Pro Ala Pro Gln His Pro Ala
545                 550                 555                 560 
Ala Ser Ala Leu Arg Thr Arg Met Thr Gly Gly Arg Pro Pro Leu Pro
                565                 570                 575     
Pro Pro Asp Asp Pro Ala Thr Leu Gly Pro His Leu Gly Leu Arg Gly
            580                 585                 590         
Val Pro Gln Ser Thr Ala Ala Ser Ser
        595                 600     


<210> 7899
<211> 227
<212> PRT
<213> Homo sapiens

<400> 7899
Met Asp Asn Ala Arg Met Asn Ser Phe Leu Glu Tyr Pro Ile Leu Ser
 1               5                  10                  15      
Ser Gly Asp Ser Gly Thr Cys Ser Ala Arg Ala Tyr Pro Ser Asp His
            20                  25                  30          
Arg Ile Thr Thr Phe Gln Ser Cys Ala Val Ser Ala Asn Ser Cys Gly
        35                  40                  45              
Gly Asp Asp Arg Phe Leu Val Gly Arg Gly Val Gln Ile Gly Ser Pro
    50                  55                  60                  
His His His His His His His His His His Pro Gln Pro Ala Thr Tyr
65                  70                  75                  80  
Gln Thr Ser Gly Asn Leu Gly Val Ser Tyr Ser His Ser Ser Cys Gly
                85                  90                  95      
Pro Ser Tyr Gly Ser Gln Asn Phe Ser Ala Pro Tyr Ser Pro Tyr Ala
            100                 105                 110         
Leu Asn Gln Glu Ala Asp Val Ser Gly Gly Tyr Pro Gln Cys Ala Pro
        115                 120                 125             
Ala Val Tyr Ser Gly Asn Leu Ser Ser Pro Met Val Gln His His His
    130                 135                 140                 
His His Gln Gly Tyr Ala Gly Gly Ala Val Gly Ser Pro Gln Tyr Ile
145                 150                 155                 160 
His His Ser Tyr Gly Gln Glu His Gln Ser Leu Ala Leu Ala Thr Tyr
                165                 170                 175     
Asn Asn Ser Leu Ser Pro Leu His Ala Ser His Gln Glu Ala Cys Arg
            180                 185                 190         
Ser Pro Ala Ser Glu Thr Ser Ser Pro Ala Gln Thr Phe Asp Trp Met
        195                 200                 205             
Lys Val Lys Arg Asn Pro Pro Lys Thr Gly Gln Ser Cys Trp Leu Val
    210                 215                 220                 
Asp Ala Pro
225         


<210> 7900
<211> 335
<212> PRT
<213> Homo sapiens

<400> 7900
Met Asp Asn Ala Arg Met Asn Ser Phe Leu Glu Tyr Pro Ile Leu Ser
 1               5                  10                  15      
Ser Gly Asp Ser Gly Thr Cys Ser Ala Arg Ala Tyr Pro Ser Asp His
            20                  25                  30          
Arg Ile Thr Thr Phe Gln Ser Cys Ala Val Ser Ala Asn Ser Cys Gly
        35                  40                  45              
Gly Asp Asp Arg Phe Leu Val Gly Arg Gly Val Gln Ile Gly Ser Pro
    50                  55                  60                  
His His His His His His His His His His Pro Gln Pro Ala Thr Tyr
65                  70                  75                  80  
Gln Thr Ser Gly Asn Leu Gly Val Ser Tyr Ser His Ser Ser Cys Gly
                85                  90                  95      
Pro Ser Tyr Gly Ser Gln Asn Phe Ser Ala Pro Tyr Ser Pro Tyr Ala
            100                 105                 110         
Leu Asn Gln Glu Ala Asp Val Ser Gly Gly Tyr Pro Gln Cys Ala Pro
        115                 120                 125             
Ala Val Tyr Ser Gly Asn Leu Ser Ser Pro Met Val Gln His His His
    130                 135                 140                 
His His Gln Gly Tyr Ala Gly Gly Ala Val Gly Ser Pro Gln Tyr Ile
145                 150                 155                 160 
His His Ser Tyr Gly Gln Glu His Gln Ser Leu Ala Leu Ala Thr Tyr
                165                 170                 175     
Asn Asn Ser Leu Ser Pro Leu His Ala Ser His Gln Glu Ala Cys Arg
            180                 185                 190         
Ser Pro Ala Ser Glu Thr Ser Ser Pro Ala Gln Thr Phe Asp Trp Met
        195                 200                 205             
Lys Val Lys Arg Asn Pro Pro Lys Thr Gly Lys Val Gly Glu Tyr Gly
    210                 215                 220                 
Tyr Leu Gly Gln Pro Asn Ala Val Arg Thr Asn Phe Thr Thr Lys Gln
225                 230                 235                 240 
Leu Thr Glu Leu Glu Lys Glu Phe His Phe Asn Lys Tyr Leu Thr Arg
                245                 250                 255     
Ala Arg Arg Val Glu Ile Ala Ala Ser Leu Gln Leu Asn Glu Thr Gln
            260                 265                 270         
Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Gln Lys Lys Arg Glu
        275                 280                 285             
Lys Glu Gly Leu Leu Pro Ile Ser Pro Ala Thr Pro Pro Gly Asn Asp
    290                 295                 300                 
Glu Lys Ala Glu Glu Ser Ser Glu Lys Ser Ser Ser Ser Pro Cys Val
305                 310                 315                 320 
Pro Ser Pro Gly Ser Ser Thr Ser Asp Thr Leu Thr Thr Ser His
                325                 330                 335 


<210> 7901
<211> 1557
<212> PRT
<213> Homo sapiens

<400> 7901
Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn
 1               5                  10                  15      
Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg
            20                  25                  30          
Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp
        35                  40                  45              
Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr
    50                  55                  60                  
Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly
65                  70                  75                  80  
Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys
                85                  90                  95      
Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu
            100                 105                 110         
Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val
        115                 120                 125             
Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln
    130                 135                 140                 
Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly
145                 150                 155                 160 
Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys
                165                 170                 175     
Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln
            180                 185                 190         
Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro
        195                 200                 205             
Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser
    210                 215                 220                 
Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val
225                 230                 235                 240 
Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe
                245                 250                 255     
Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp
            260                 265                 270         
Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val
        275                 280                 285             
Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser
    290                 295                 300                 
Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser
305                 310                 315                 320 
Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys
                325                 330                 335     
Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys
            340                 345                 350         
Ala His Gln Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu Ile
        355                 360                 365             
Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln
    370                 375                 380                 
Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys
385                 390                 395                 400 
Ala His Leu Tyr Ser Arg Phe Leu Ile Asp Pro Phe Phe Pro Asn Met
                405                 410                 415     
Ile Pro Asn Met Ile Phe Ser Phe Ser Lys Ala Ala Ile Gly Cys Gly
            420                 425                 430         
Ile Val Glu Ser Ile Leu Asn Trp Val Lys Phe Lys Ala Gln Val Gln
        435                 440                 445             
Leu Asn Lys Lys Cys Ser Ala Val Lys His Asn Arg Ile Lys Gly Ile
    450                 455                 460                 
Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly Gly Arg Asn Ser Thr Glu
465                 470                 475                 480 
Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser Ala Lys Thr Leu Ala Val
                485                 490                 495     
Ser Gly Leu Gly Val Val Gly Arg Asp Lys Tyr Gly Val Phe Pro Leu
            500                 505                 510         
Arg Gly Lys Ile Leu Asn Val Arg Glu Ala Ser His Lys Gln Ile Met
        515                 520                 525             
Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys Ile Val Gly Leu Gln Tyr
    530                 535                 540                 
Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu Lys Thr Leu Arg Tyr Gly
545                 550                 555                 560 
Lys Ile Met Ile Met Thr Asp Gln Asp Gln Asp Gly Ser His Ile Lys
                565                 570                 575     
Gly Leu Leu Ile Asn Phe Ile His His Asn Trp Pro Ser Leu Leu Arg
            580                 585                 590         
His Arg Phe Leu Glu Glu Phe Ile Thr Pro Ile Val Lys Val Ser Lys
        595                 600                 605             
Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu Pro Glu Phe Glu Glu Trp
    610                 615                 620                 
Lys Ser Ser Thr Pro Asn His Lys Lys Trp Lys Val Lys Tyr Tyr Lys
625                 630                 635                 640 
Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala Lys Glu Tyr Phe Ala Asp
                645                 650                 655     
Met Lys Arg His Arg Ile Gln Phe Lys Tyr Ser Gly Pro Glu Asp Asp
            660                 665                 670         
Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys Gln Ile Asp Asp Arg Lys
        675                 680                 685             
Glu Trp Leu Thr Asn Phe Met Glu Asp Arg Arg Gln Arg Lys Leu Leu
    690                 695                 700                 
Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln Thr Thr Thr Tyr Leu Thr
705                 710                 715                 720 
Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile Leu Phe Ser Asn Ser Asp
                725                 730                 735     
Asn Glu Arg Ser Ile Pro Ser Met Val Asp Gly Leu Lys Pro Gly Gln
            740                 745                 750         
Arg Lys Val Leu Phe Thr Cys Phe Lys Arg Asn Asp Lys Arg Glu Val
        755                 760                 765             
Lys Val Ala Gln Leu Ala Gly Ser Val Ala Glu Met Ser Ser Tyr His
    770                 775                 780                 
His Gly Glu Met Ser Leu Met Met Thr Ile Ile Asn Leu Ala Gln Asn
785                 790                 795                 800 
Phe Val Gly Ser Asn Asn Leu Asn Leu Leu Gln Pro Ile Gly Gln Phe
                805                 810                 815     
Gly Thr Arg Leu His Gly Gly Lys Asp Ser Ala Ser Pro Arg Tyr Ile
            820                 825                 830         
Phe Thr Met Leu Ser Ser Leu Ala Arg Leu Leu Phe Pro Pro Lys Asp
        835                 840                 845             
Asp His Thr Leu Lys Phe Leu Tyr Asp Asp Asn Gln Arg Val Glu Pro
    850                 855                 860                 
Glu Trp Tyr Ile Pro Ile Ile Pro Met Val Leu Ile Asn Gly Ala Glu
865                 870                 875                 880 
Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile Pro Asn Phe Asp Val Arg
                885                 890                 895     
Glu Ile Val Asn Asn Ile Arg Arg Leu Met Asp Gly Glu Glu Pro Leu
            900                 905                 910         
Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys Gly Thr Ile Glu Glu Leu
        915                 920                 925             
Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu Val Ala Ile Leu Asn Ser
    930                 935                 940                 
Thr Thr Ile Glu Ile Ser Glu Leu Pro Val Arg Thr Trp Thr Gln Thr
945                 950                 955                 960 
Tyr Lys Glu Gln Val Leu Glu Pro Met Leu Asn Gly Thr Glu Lys Thr
                965                 970                 975     
Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr His Thr Asp Thr Thr Val
            980                 985                 990         
Lys Phe Val Val Lys Met Thr Glu Glu Lys Leu Ala Glu Ala Glu Arg
        995                 1000                1005            
Val Gly Leu His Lys Val Phe Lys Leu Gln Thr Ser Leu Thr Cys Asn
    1010                1015                1020                
Ser Met Val Leu Phe Asp His Val Gly Cys Leu Lys Lys Tyr Asp Thr
1025                1030                1035                1040
Val Leu Asp Ile Leu Arg Asp Phe Phe Glu Leu Arg Leu Lys Tyr Tyr
                1045                1050                1055    
Gly Leu Arg Lys Glu Trp Leu Leu Gly Met Leu Gly Ala Glu Ser Ala
            1060                1065                1070        
Lys Leu Asn Asn Gln Ala Arg Phe Ile Leu Glu Lys Ile Asp Gly Lys
        1075                1080                1085            
Ile Ile Ile Glu Asn Lys Pro Lys Lys Glu Leu Ile Lys Val Leu Ile
    1090                1095                1100                
Gln Arg Gly Tyr Asp Ser Asp Pro Val Lys Ala Trp Lys Glu Ala Gln
1105                1110                1115                1120
Gln Lys Val Pro Asp Glu Glu Glu Asn Glu Glu Ser Asp Asn Glu Lys
                1125                1130                1135    
Glu Thr Glu Lys Ser Asp Ser Val Thr Asp Ser Gly Pro Thr Phe Asn
            1140                1145                1150        
Tyr Leu Leu Asp Met Pro Leu Trp Tyr Leu Thr Lys Glu Lys Lys Asp
        1155                1160                1165            
Glu Leu Cys Arg Leu Arg Asn Glu Lys Glu Gln Glu Leu Asp Thr Leu
    1170                1175                1180                
Lys Arg Lys Ser Pro Ser Asp Leu Trp Lys Glu Asp Leu Ala Thr Phe
1185                1190                1195                1200
Ile Glu Glu Leu Glu Ala Val Glu Ala Lys Glu Lys Gln Asp Glu Gln
                1205                1210                1215    
Val Gly Leu Pro Gly Lys Gly Gly Lys Ala Lys Gly Lys Lys Thr Gln
            1220                1225                1230        
Met Ala Glu Val Leu Pro Ser Pro Arg Gly Gln Arg Val Ile Pro Arg
        1235                1240                1245            
Ile Thr Ile Glu Met Lys Ala Glu Ala Glu Lys Lys Asn Lys Lys Lys
    1250                1255                1260                
Ile Lys Asn Glu Asn Thr Glu Gly Ser Pro Gln Glu Asp Gly Val Glu
1265                1270                1275                1280
Leu Glu Gly Leu Lys Gln Arg Leu Glu Lys Lys Gln Lys Arg Glu Pro
                1285                1290                1295    
Gly Thr Lys Thr Lys Lys Gln Thr Thr Leu Ala Phe Lys Pro Ile Lys
            1300                1305                1310        
Lys Gly Lys Lys Arg Asn Pro Trp Ser Asp Ser Glu Ser Asp Arg Ser
        1315                1320                1325            
Ser Asp Glu Ser Asn Phe Asp Val Pro Pro Arg Glu Thr Glu Pro Arg
    1330                1335                1340                
Arg Ala Ala Thr Lys Thr Lys Phe Thr Met Asp Leu Asp Ser Asp Glu
1345                1350                1355                1360
Asp Phe Ser Asp Phe Asp Glu Lys Thr Asp Asp Glu Asp Phe Val Pro
                1365                1370                1375    
Ser Asp Ala Ser Pro Pro Lys Thr Lys Thr Ser Pro Lys Leu Ser Asn
            1380                1385                1390        
Lys Glu Leu Lys Pro Gln Lys Ser Val Val Ser Asp Leu Glu Ala Asp
        1395                1400                1405            
Asp Val Lys Gly Ser Val Pro Leu Ser Ser Ser Pro Pro Ala Thr His
    1410                1415                1420                
Phe Pro Asp Glu Thr Glu Ile Thr Asn Pro Val Pro Lys Lys Asn Val
1425                1430                1435                1440
Thr Val Lys Lys Thr Ala Ala Lys Ser Gln Ser Ser Thr Ser Thr Thr
                1445                1450                1455    
Gly Ala Lys Lys Arg Ala Ala Pro Lys Gly Thr Lys Arg Asp Pro Ala
            1460                1465                1470        
Leu Asn Ser Gly Val Ser Gln Lys Pro Asp Pro Ala Lys Thr Lys Asn
        1475                1480                1485            
Arg Arg Lys Arg Lys Pro Ser Thr Ser Asp Asp Ser Asp Ser Asn Phe
    1490                1495                1500                
Glu Lys Ile Val Ser Lys Ala Val Thr Ser Lys Lys Ser Lys Gly Glu
1505                1510                1515                1520
Ser Asp Asp Phe His Met Asp Phe Asp Ser Ala Val Ala Pro Arg Ala
                1525                1530                1535    
Lys Ser Val Arg Ala Lys Lys Pro Ile Lys Tyr Leu Glu Glu Ser Asp
            1540                1545                1550        
Glu Asp Asp Leu Phe
        1555        


<210> 7902
<211> 1612
<212> PRT
<213> Homo sapiens

<400> 7902
Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn
 1               5                  10                  15      
Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg
            20                  25                  30          
Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp
        35                  40                  45              
Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr
    50                  55                  60                  
Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly
65                  70                  75                  80  
Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys
                85                  90                  95      
Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu
            100                 105                 110         
Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val
        115                 120                 125             
Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln
    130                 135                 140                 
Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly
145                 150                 155                 160 
Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys
                165                 170                 175     
Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln
            180                 185                 190         
Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro
        195                 200                 205             
Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser
    210                 215                 220                 
Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val
225                 230                 235                 240 
Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe
                245                 250                 255     
Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp
            260                 265                 270         
Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val
        275                 280                 285             
Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser
    290                 295                 300                 
Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser
305                 310                 315                 320 
Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys
                325                 330                 335     
Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys
            340                 345                 350         
Ala His Gln Arg Glu Leu Cys Asn Gly Ala Ile Leu Ala His Cys Asn
        355                 360                 365             
Leu Arg Leu Met Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val
    370                 375                 380                 
Ala Gly Ile Ala Gly Gly Cys His His Thr Gln Leu Ile Phe Val Phe
385                 390                 395                 400 
Leu Val Glu Thr Gly Phe His His Val Gly Gln Ala Gly Leu Glu Arg
                405                 410                 415     
Leu Thr Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ser Gly Ile
            420                 425                 430         
Thr Asp Val Lys Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu
        435                 440                 445             
Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu
    450                 455                 460                 
Gln Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile
465                 470                 475                 480 
Lys Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val
                485                 490                 495     
Lys Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys
            500                 505                 510         
His Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala
        515                 520                 525             
Gly Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp
    530                 535                 540                 
Ser Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp
545                 550                 555                 560 
Lys Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu
                565                 570                 575     
Ala Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile
            580                 585                 590         
Lys Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser
        595                 600                 605             
Leu Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp
    610                 615                 620                 
Gln Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His
625                 630                 635                 640 
Asn Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr
                645                 650                 655     
Pro Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala Phe Tyr Ser
            660                 665                 670         
Leu Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn His Lys Lys
        675                 680                 685             
Trp Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu
    690                 695                 700                 
Ala Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile Gln Phe Lys
705                 710                 715                 720 
Tyr Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys
                725                 730                 735     
Lys Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp
            740                 745                 750         
Arg Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly
        755                 760                 765             
Gln Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu
    770                 775                 780                 
Ile Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val
785                 790                 795                 800 
Asp Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys
                805                 810                 815     
Arg Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val
            820                 825                 830         
Ala Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr
        835                 840                 845             
Ile Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu
    850                 855                 860                 
Leu Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp
865                 870                 875                 880 
Ser Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser Leu Ala Arg
                885                 890                 895     
Leu Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe Leu Tyr Asp
            900                 905                 910         
Asp Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met
        915                 920                 925             
Val Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys
    930                 935                 940                 
Ile Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile Arg Arg Leu
945                 950                 955                 960 
Met Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Phe
                965                 970                 975     
Lys Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly
            980                 985                 990         
Glu Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser Glu Leu Pro
        995                 1000                1005            
Val Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu Glu Pro Met
    1010                1015                1020                
Leu Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp Tyr Arg Glu
1025                1030                1035                1040
Tyr His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu
                1045                1050                1055    
Lys Leu Ala Glu Ala Glu Arg Val Gly Leu His Lys Val Phe Lys Leu
            1060                1065                1070        
Gln Thr Ser Leu Thr Cys Asn Ser Met Val Leu Phe Asp His Val Gly
        1075                1080                1085            
Cys Leu Lys Lys Tyr Asp Thr Val Leu Asp Ile Leu Arg Asp Phe Phe
    1090                1095                1100                
Glu Leu Arg Leu Lys Tyr Tyr Gly Leu Arg Lys Glu Trp Leu Leu Gly
1105                1110                1115                1120
Met Leu Gly Ala Glu Ser Ala Lys Leu Asn Asn Gln Ala Arg Phe Ile
                1125                1130                1135    
Leu Glu Lys Ile Asp Gly Lys Ile Ile Ile Glu Asn Lys Pro Lys Lys
            1140                1145                1150        
Glu Leu Ile Lys Val Leu Ile Gln Arg Gly Tyr Asp Ser Asp Pro Val
        1155                1160                1165            
Lys Ala Trp Lys Glu Ala Gln Gln Lys Val Pro Asp Glu Glu Glu Asn
    1170                1175                1180                
Glu Glu Ser Asp Asn Glu Lys Glu Thr Glu Lys Ser Asp Ser Val Thr
1185                1190                1195                1200
Asp Ser Gly Pro Thr Phe Asn Tyr Leu Leu Asp Met Pro Leu Trp Tyr
                1205                1210                1215    
Leu Thr Lys Glu Lys Lys Asp Glu Leu Cys Arg Leu Arg Asn Glu Lys
            1220                1225                1230        
Glu Gln Glu Leu Asp Thr Leu Lys Arg Lys Ser Pro Ser Asp Leu Trp
        1235                1240                1245            
Lys Glu Asp Leu Ala Thr Phe Ile Glu Glu Leu Glu Ala Val Glu Ala
    1250                1255                1260                
Lys Glu Lys Gln Asp Glu Gln Val Gly Leu Pro Gly Lys Gly Gly Lys
1265                1270                1275                1280
Ala Lys Gly Lys Lys Thr Gln Met Ala Glu Val Leu Pro Ser Pro Arg
                1285                1290                1295    
Gly Gln Arg Val Ile Pro Arg Ile Thr Ile Glu Met Lys Ala Glu Ala
            1300                1305                1310        
Glu Lys Lys Asn Lys Lys Lys Ile Lys Asn Glu Asn Thr Glu Gly Ser
        1315                1320                1325            
Pro Gln Glu Asp Gly Val Glu Leu Glu Gly Leu Lys Gln Arg Leu Glu
    1330                1335                1340                
Lys Lys Gln Lys Arg Glu Pro Gly Thr Lys Thr Lys Lys Gln Thr Thr
1345                1350                1355                1360
Leu Ala Phe Lys Pro Ile Lys Lys Gly Lys Lys Arg Asn Pro Trp Ser
                1365                1370                1375    
Asp Ser Glu Ser Asp Arg Ser Ser Asp Glu Ser Asn Phe Asp Val Pro
            1380                1385                1390        
Pro Arg Glu Thr Glu Pro Arg Arg Ala Ala Thr Lys Thr Lys Phe Thr
        1395                1400                1405            
Met Asp Leu Asp Ser Asp Glu Asp Phe Ser Asp Phe Asp Glu Lys Thr
    1410                1415                1420                
Asp Asp Glu Asp Phe Val Pro Ser Asp Ala Ser Pro Pro Lys Thr Lys
1425                1430                1435                1440
Thr Ser Pro Lys Leu Ser Asn Lys Glu Leu Lys Pro Gln Lys Ser Val
                1445                1450                1455    
Val Ser Asp Leu Glu Ala Asp Asp Val Lys Gly Ser Val Pro Leu Ser
            1460                1465                1470        
Ser Ser Pro Pro Ala Thr His Phe Pro Asp Glu Thr Glu Ile Thr Asn
        1475                1480                1485            
Pro Val Pro Lys Lys Asn Val Thr Val Lys Lys Thr Ala Ala Lys Ser
    1490                1495                1500                
Gln Ser Ser Thr Ser Thr Thr Gly Ala Lys Lys Arg Ala Ala Pro Lys
1505                1510                1515                1520
Gly Thr Lys Arg Asp Pro Ala Leu Asn Ser Gly Val Ser Gln Lys Pro
                1525                1530                1535    
Asp Pro Ala Lys Thr Lys Asn Arg Arg Lys Arg Lys Pro Ser Thr Ser
            1540                1545                1550        
Asp Asp Ser Asp Ser Asn Phe Glu Lys Ile Val Ser Lys Ala Val Thr
        1555                1560                1565            
Ser Lys Lys Ser Lys Gly Glu Ser Asp Asp Phe His Met Asp Phe Asp
    1570                1575                1580                
Ser Ala Val Ala Pro Arg Ala Lys Ser Val Arg Ala Lys Lys Pro Ile
1585                1590                1595                1600
Lys Tyr Leu Glu Glu Ser Asp Glu Asp Asp Leu Phe
                1605                1610        


<210> 7903
<211> 1534
<212> PRT
<213> Homo sapiens

<400> 7903
Pro Val Asn Glu Asn Met Gln Val Asn Lys Ile Lys Lys Asn Glu Asp
 1               5                  10                  15      
Ala Lys Lys Arg Leu Ser Val Glu Arg Ile Tyr Gln Lys Lys Thr Gln
            20                  25                  30          
Leu Glu His Ile Leu Leu Arg Pro Asp Thr Tyr Ile Gly Ser Val Glu
        35                  40                  45              
Leu Val Thr Gln Gln Met Trp Val Tyr Asp Glu Asp Val Gly Ile Asn
    50                  55                  60                  
Tyr Arg Glu Val Thr Phe Val Pro Gly Leu Tyr Lys Ile Phe Asp Glu
65                  70                  75                  80  
Ile Leu Val Asn Ala Ala Asp Asn Lys Gln Arg Asp Pro Lys Met Ser
                85                  90                  95      
Cys Ile Arg Val Thr Ile Asp Pro Glu Asn Asn Leu Ile Ser Ile Trp
            100                 105                 110         
Asn Asn Gly Lys Gly Ile Pro Val Val Glu His Lys Val Glu Lys Met
        115                 120                 125             
Tyr Val Pro Ala Leu Ile Phe Gly Gln Leu Leu Thr Ser Ser Asn Tyr
    130                 135                 140                 
Asp Asp Asp Glu Lys Lys Val Thr Gly Gly Arg Asn Gly Tyr Gly Ala
145                 150                 155                 160 
Lys Leu Cys Asn Ile Phe Ser Thr Lys Phe Thr Val Glu Thr Ala Ser
                165                 170                 175     
Arg Glu Tyr Lys Lys Met Phe Lys Gln Ala Asn Trp Met Asp Asn Met
            180                 185                 190         
Gly Arg Ala Gly Glu Met Glu Leu Lys Pro Phe Asn Gly Glu Asp Tyr
        195                 200                 205             
Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser Lys Phe Lys Met Gln Ser
    210                 215                 220                 
Leu Asp Lys Asp Ile Val Ala Leu Met Val Arg Arg Ala Tyr Asp Ile
225                 230                 235                 240 
Ala Gly Ser Thr Lys Asp Val Lys Val Phe Leu Asn Gly Asn Lys Leu
                245                 250                 255     
Pro Val Lys Gly Phe Arg Ser Tyr Val Asp Met Tyr Leu Lys Asp Lys
            260                 265                 270         
Leu Asp Glu Thr Gly Asn Ser Leu Lys Val Ile His Glu Gln Val Asn
        275                 280                 285             
His Arg Trp Glu Val Cys Leu Thr Met Ser Glu Lys Gly Phe Gln Gln
    290                 295                 300                 
Ile Ser Phe Val Asn Ser Ile Ala Thr Ser Lys Gly Gly Arg His Val
305                 310                 315                 320 
Asp Tyr Val Ala Asp Gln Ile Val Thr Lys Leu Val Asp Val Val Lys
                325                 330                 335     
Lys Lys Asn Lys Gly Gly Val Ala Val Lys Ala His Gln Val Lys Asn
            340                 345                 350         
His Met Trp Ile Phe Val Asn Ala Leu Ile Glu Asn Pro Thr Phe Asp
        355                 360                 365             
Ser Gln Thr Lys Glu Asn Met Thr Leu Gln Pro Lys Ser Phe Gly Ser
    370                 375                 380                 
Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys Ala Ala Ile Gly Cys Gly
385                 390                 395                 400 
Ile Val Glu Ser Ile Leu Asn Trp Val Lys Phe Lys Ala Gln Val Gln
                405                 410                 415     
Leu Asn Lys Lys Cys Ser Ala Val Lys His Asn Arg Ile Lys Gly Ile
            420                 425                 430         
Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly Gly Arg Asn Ser Thr Glu
        435                 440                 445             
Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser Ala Lys Thr Leu Ala Val
    450                 455                 460                 
Ser Gly Leu Gly Val Val Gly Arg Asp Lys Tyr Gly Val Phe Pro Leu
465                 470                 475                 480 
Arg Gly Lys Ile Leu Asn Val Arg Glu Ala Ser His Lys Gln Ile Met
                485                 490                 495     
Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys Ile Val Gly Leu Gln Tyr
            500                 505                 510         
Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu Lys Thr Leu Arg Tyr Gly
        515                 520                 525             
Lys Ile Met Ile Met Thr Asp Gln Asp Gln Asp Gly Ser His Ile Lys
    530                 535                 540                 
Gly Leu Leu Ile Asn Phe Ile His His Asn Trp Pro Ser Leu Leu Arg
545                 550                 555                 560 
His Arg Phe Leu Glu Glu Phe Ile Thr Pro Ile Val Lys Val Ser Lys
                565                 570                 575     
Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu Pro Glu Phe Glu Glu Trp
            580                 585                 590         
Lys Ser Ser Thr Pro Asn His Lys Lys Trp Lys Val Lys Tyr Tyr Lys
        595                 600                 605             
Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala Lys Glu Tyr Phe Ala Asp
    610                 615                 620                 
Met Lys Arg His Arg Ile Gln Phe Lys Tyr Ser Gly Pro Glu Asp Asp
625                 630                 635                 640 
Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys Gln Ile Asp Asp Arg Lys
                645                 650                 655     
Glu Trp Leu Thr Asn Phe Met Glu Asp Arg Arg Gln Arg Lys Leu Leu
            660                 665                 670         
Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln Thr Thr Thr Tyr Leu Thr
        675                 680                 685             
Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile Leu Phe Ser Asn Ser Asp
    690                 695                 700                 
Asn Glu Arg Ser Ile Pro Ser Met Val Asp Gly Leu Lys Pro Gly Gln
705                 710                 715                 720 
Arg Lys Val Leu Phe Thr Cys Phe Lys Arg Asn Asp Lys Arg Glu Val
                725                 730                 735     
Lys Val Ala Gln Leu Ala Gly Ser Val Ala Glu Met Ser Ser Tyr His
            740                 745                 750         
His Gly Glu Met Ser Leu Met Met Thr Ile Ile Asn Leu Ala Gln Asn
        755                 760                 765             
Phe Val Gly Ser Asn Asn Leu Asn Leu Leu Gln Pro Ile Gly Gln Phe
    770                 775                 780                 
Gly Thr Arg Leu His Gly Gly Lys Asp Ser Ala Ser Pro Arg Tyr Ile
785                 790                 795                 800 
Phe Thr Met Leu Ser Ser Leu Ala Arg Leu Leu Phe Pro Pro Lys Asp
                805                 810                 815     
Asp His Thr Leu Lys Phe Leu Tyr Asp Asp Asn Gln Arg Val Glu Pro
            820                 825                 830         
Glu Trp Tyr Ile Pro Ile Ile Pro Met Val Leu Ile Asn Gly Ala Glu
        835                 840                 845             
Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile Pro Asn Phe Asp Val Arg
    850                 855                 860                 
Glu Ile Val Asn Asn Ile Arg Arg Leu Met Asp Gly Glu Glu Pro Leu
865                 870                 875                 880 
Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys Gly Thr Ile Glu Glu Leu
                885                 890                 895     
Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu Val Ala Ile Leu Asn Ser
            900                 905                 910         
Thr Thr Ile Glu Ile Ser Glu Leu Pro Val Arg Thr Trp Thr Gln Thr
        915                 920                 925             
Tyr Lys Glu Gln Val Leu Glu Pro Met Leu Asn Gly Thr Glu Lys Thr
    930                 935                 940                 
Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr His Thr Asp Thr Thr Val
945                 950                 955                 960 
Lys Phe Val Val Lys Met Thr Glu Glu Lys Leu Ala Glu Ala Glu Arg
                965                 970                 975     
Val Gly Leu His Lys Val Phe Lys Leu Gln Thr Ser Leu Thr Cys Asn
            980                 985                 990         
Ser Met Val Leu Phe Asp His Val Gly Cys Leu Lys Lys Tyr Asp Thr
        995                 1000                1005            
Val Leu Asp Ile Leu Arg Asp Phe Phe Glu Leu Arg Leu Lys Tyr Tyr
    1010                1015                1020                
Gly Leu Arg Lys Glu Trp Leu Leu Gly Met Leu Gly Ala Glu Ser Ala
1025                1030                1035                1040
Lys Leu Asn Asn Gln Ala Arg Phe Ile Leu Glu Lys Ile Asp Gly Lys
                1045                1050                1055    
Ile Ile Ile Glu Asn Lys Pro Lys Lys Glu Leu Ile Lys Val Leu Ile
            1060                1065                1070        
Gln Arg Gly Tyr Asp Ser Asp Pro Val Lys Ala Trp Lys Glu Ala Gln
        1075                1080                1085            
Gln Lys Val Pro Asp Glu Glu Glu Asn Glu Glu Ser Asp Asn Glu Lys
    1090                1095                1100                
Glu Thr Glu Lys Ser Asp Ser Val Thr Asp Ser Gly Pro Thr Phe Asn
1105                1110                1115                1120
Tyr Leu Leu Asp Met Pro Leu Trp Tyr Leu Thr Lys Glu Lys Lys Asp
                1125                1130                1135    
Glu Leu Cys Arg Leu Arg Asn Glu Lys Glu Gln Glu Leu Asp Thr Leu
            1140                1145                1150        
Lys Arg Lys Ser Pro Ser Asp Leu Trp Lys Glu Asp Leu Ala Thr Phe
        1155                1160                1165            
Ile Glu Glu Leu Glu Ala Val Glu Ala Lys Glu Lys Gln Asp Glu Gln
    1170                1175                1180                
Val Gly Leu Pro Gly Lys Gly Gly Lys Ala Lys Gly Lys Lys Thr Gln
1185                1190                1195                1200
Met Ala Glu Val Leu Pro Ser Pro Arg Gly Gln Arg Val Ile Pro Arg
                1205                1210                1215    
Ile Thr Ile Glu Met Lys Ala Glu Ala Glu Lys Lys Asn Lys Lys Lys
            1220                1225                1230        
Ile Lys Asn Glu Asn Thr Glu Gly Ser Pro Gln Glu Asp Gly Val Glu
        1235                1240                1245            
Leu Glu Gly Leu Lys Gln Arg Leu Glu Lys Lys Gln Lys Arg Glu Pro
    1250                1255                1260                
Gly Thr Lys Thr Lys Lys Gln Thr Thr Leu Ala Phe Lys Pro Ile Lys
1265                1270                1275                1280
Lys Gly Lys Lys Arg Asn Pro Trp Ser Asp Ser Glu Ser Asp Arg Ser
                1285                1290                1295    
Ser Asp Glu Ser Asn Phe Asp Val Pro Pro Arg Glu Thr Glu Pro Arg
            1300                1305                1310        
Arg Ala Ala Thr Lys Thr Lys Phe Thr Met Asp Leu Asp Ser Asp Glu
        1315                1320                1325            
Asp Phe Ser Asp Phe Asp Glu Lys Thr Asp Asp Glu Asp Phe Val Pro
    1330                1335                1340                
Ser Asp Ala Ser Pro Pro Lys Thr Lys Thr Ser Pro Lys Gln Val Ser
1345                1350                1355                1360
Tyr Leu Ile Trp Val Leu Leu Ser Asn Lys Glu Leu Lys Pro Gln Lys
                1365                1370                1375    
Ser Val Val Ser Asp Leu Glu Ala Asp Asp Val Lys Gly Ser Val Pro
            1380                1385                1390        
Leu Ser Ser Ser Pro Pro Ala Thr His Phe Pro Asp Glu Thr Glu Ile
        1395                1400                1405            
Thr Asn Pro Val Pro Lys Lys Asn Val Thr Val Lys Lys Thr Ala Ala
    1410                1415                1420                
Lys Ser Gln Ser Ser Thr Ser Thr Thr Gly Ala Lys Lys Arg Ala Ala
1425                1430                1435                1440
Pro Lys Gly Thr Lys Arg Asp Pro Ala Leu Asn Ser Gly Val Ser Gln
                1445                1450                1455    
Lys Pro Asp Pro Ala Lys Thr Lys Asn Arg Arg Lys Arg Lys Pro Ser
            1460                1465                1470        
Thr Ser Asp Asp Ser Asp Ser Asn Phe Glu Lys Ile Val Ser Lys Ala
        1475                1480                1485            
Val Thr Ser Lys Lys Ser Lys Gly Glu Ser Asp Asp Phe His Met Asp
    1490                1495                1500                
Phe Asp Ser Ala Val Ala Pro Arg Ala Lys Ser Val Arg Ala Lys Lys
1505                1510                1515                1520
Pro Ile Lys Tyr Leu Glu Glu Ser Asp Glu Asp Asp Leu Phe
                1525                1530                


<210> 7904
<211> 1567
<212> PRT
<213> Homo sapiens

<400> 7904
Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn
 1               5                  10                  15      
Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg
            20                  25                  30          
Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp
        35                  40                  45              
Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr
    50                  55                  60                  
Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly
65                  70                  75                  80  
Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys
                85                  90                  95      
Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu
            100                 105                 110         
Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val
        115                 120                 125             
Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln
    130                 135                 140                 
Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly
145                 150                 155                 160 
Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys
                165                 170                 175     
Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln
            180                 185                 190         
Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro
        195                 200                 205             
Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser
    210                 215                 220                 
Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val
225                 230                 235                 240 
Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe
                245                 250                 255     
Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp
            260                 265                 270         
Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val
        275                 280                 285             
Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser
    290                 295                 300                 
Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser
305                 310                 315                 320 
Lys Ser Ser Lys Tyr Trp Ser Ser Arg Lys Ser Lys Gln His Ile Leu
                325                 330                 335     
Leu Asn Phe Phe Val Leu Phe Lys Phe Ile Asn Asp Ala Phe Phe Gly
            340                 345                 350         
Ile Cys Pro Phe Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln
        355                 360                 365             
Ile Val Thr Lys Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly
    370                 375                 380                 
Val Ala Val Lys Ala His Gln Val Lys Asn His Met Trp Ile Phe Val
385                 390                 395                 400 
Asn Ala Leu Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn
                405                 410                 415     
Met Thr Leu Gln Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu
            420                 425                 430         
Lys Phe Ile Lys Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu
        435                 440                 445             
Asn Trp Val Lys Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser
    450                 455                 460                 
Ala Val Lys His Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala
465                 470                 475                 480 
Asn Asp Ala Gly Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr
                485                 490                 495     
Glu Gly Asp Ser Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val
            500                 505                 510         
Gly Arg Asp Lys Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn
        515                 520                 525             
Val Arg Glu Ala Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn
    530                 535                 540                 
Asn Ile Ile Lys Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp
545                 550                 555                 560 
Glu Asp Ser Leu Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr
                565                 570                 575     
Asp Gln Asp Gln Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe
            580                 585                 590         
Ile His His Asn Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu
        595                 600                 605             
Phe Ile Thr Pro Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala
    610                 615                 620                 
Phe Tyr Ser Leu Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn
625                 630                 635                 640 
His Lys Lys Trp Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr
                645                 650                 655     
Ser Lys Glu Ala Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile
            660                 665                 670         
Gln Phe Lys Tyr Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala
        675                 680                 685             
Phe Ser Lys Lys Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe
    690                 695                 700                 
Met Glu Asp Arg Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr
705                 710                 715                 720 
Leu Tyr Gly Gln Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn
                725                 730                 735     
Lys Glu Leu Ile Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro
            740                 745                 750         
Ser Met Val Asp Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr
        755                 760                 765             
Cys Phe Lys Arg Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala
    770                 775                 780                 
Gly Ser Val Ala Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu
785                 790                 795                 800 
Met Met Thr Ile Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn
                805                 810                 815     
Leu Asn Leu Leu Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly
            820                 825                 830         
Gly Lys Asp Ser Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser
        835                 840                 845             
Leu Ala Arg Leu Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe
    850                 855                 860                 
Leu Tyr Asp Asp Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile
865                 870                 875                 880 
Ile Pro Met Val Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp
                885                 890                 895     
Ser Cys Lys Ile Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile
            900                 905                 910         
Arg Arg Leu Met Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr
        915                 920                 925             
Lys Asn Phe Lys Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val
    930                 935                 940                 
Ile Ser Gly Glu Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser
945                 950                 955                 960 
Glu Leu Pro Val Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu
                965                 970                 975     
Glu Pro Met Leu Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp
            980                 985                 990         
Tyr Arg Glu Tyr His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met
        995                 1000                1005            
Thr Glu Glu Lys Leu Ala Glu Ala Glu Arg Val Gly Leu His Lys Val
    1010                1015                1020                
Phe Lys Leu Gln Thr Ser Leu Thr Cys Asn Ser Met Val Leu Phe Asp
1025                1030                1035                1040
His Val Gly Cys Leu Lys Lys Tyr Asp Thr Val Leu Asp Ile Leu Arg
                1045                1050                1055    
Asp Phe Phe Glu Leu Arg Leu Lys Tyr Tyr Gly Leu Arg Lys Glu Trp
            1060                1065                1070        
Leu Leu Gly Met Leu Gly Ala Glu Ser Ala Lys Leu Asn Asn Gln Ala
        1075                1080                1085            
Arg Phe Ile Leu Glu Lys Ile Asp Gly Lys Ile Ile Ile Glu Asn Lys
    1090                1095                1100                
Pro Lys Lys Glu Leu Ile Lys Val Leu Ile Gln Arg Gly Tyr Asp Ser
1105                1110                1115                1120
Asp Pro Val Lys Ala Trp Lys Glu Ala Gln Gln Lys Val Pro Asp Glu
                1125                1130                1135    
Glu Glu Asn Glu Glu Ser Asp Asn Glu Lys Glu Thr Glu Lys Ser Asp
            1140                1145                1150        
Ser Val Thr Asp Ser Gly Pro Thr Phe Asn Tyr Leu Leu Asp Met Pro
        1155                1160                1165            
Leu Trp Tyr Leu Thr Lys Glu Lys Lys Asp Glu Leu Cys Arg Leu Arg
    1170                1175                1180                
Asn Glu Lys Glu Gln Glu Leu Asp Thr Leu Lys Arg Lys Ser Pro Ser
1185                1190                1195                1200
Asp Leu Trp Lys Glu Asp Leu Ala Thr Phe Ile Glu Glu Leu Glu Ala
                1205                1210                1215    
Val Glu Ala Lys Glu Lys Gln Asp Glu Gln Val Gly Leu Pro Gly Lys
            1220                1225                1230        
Gly Gly Lys Ala Lys Gly Lys Lys Thr Gln Met Ala Glu Val Leu Pro
        1235                1240                1245            
Ser Pro Arg Gly Gln Arg Val Ile Pro Arg Ile Thr Ile Glu Met Lys
    1250                1255                1260                
Ala Glu Ala Glu Lys Lys Asn Lys Lys Lys Ile Lys Asn Glu Asn Thr
1265                1270                1275                1280
Glu Gly Ser Pro Gln Glu Asp Gly Val Glu Leu Glu Gly Leu Lys Gln
                1285                1290                1295    
Arg Leu Glu Lys Lys Gln Lys Arg Glu Pro Gly Thr Lys Thr Lys Lys
            1300                1305                1310        
Gln Thr Thr Leu Ala Phe Lys Pro Ile Lys Lys Gly Lys Lys Arg Asn
        1315                1320                1325            
Pro Trp Ser Asp Ser Glu Ser Asp Arg Ser Ser Asp Glu Ser Asn Phe
    1330                1335                1340                
Asp Val Pro Pro Arg Glu Thr Glu Pro Arg Arg Ala Ala Thr Lys Thr
1345                1350                1355                1360
Lys Phe Thr Met Asp Leu Asp Ser Asp Glu Asp Phe Ser Asp Phe Asp
                1365                1370                1375    
Glu Lys Thr Asp Asp Glu Asp Phe Val Pro Ser Asp Ala Ser Pro Pro
            1380                1385                1390        
Lys Thr Lys Thr Ser Pro Lys Leu Ser Asn Lys Glu Leu Lys Pro Gln
        1395                1400                1405            
Lys Ser Val Val Ser Asp Leu Glu Ala Asp Asp Val Lys Gly Ser Val
    1410                1415                1420                
Pro Leu Ser Ser Ser Pro Pro Ala Thr His Phe Pro Asp Glu Thr Glu
1425                1430                1435                1440
Ile Thr Asn Pro Val Pro Lys Lys Asn Val Thr Val Lys Lys Thr Ala
                1445                1450                1455    
Ala Lys Ser Gln Ser Ser Thr Ser Thr Thr Gly Ala Lys Lys Arg Ala
            1460                1465                1470        
Ala Pro Lys Gly Thr Lys Arg Asp Pro Ala Leu Asn Ser Gly Val Ser
        1475                1480                1485            
Gln Lys Pro Asp Pro Ala Lys Thr Lys Asn Arg Arg Lys Arg Lys Pro
    1490                1495                1500                
Ser Thr Ser Asp Asp Ser Asp Ser Asn Phe Glu Lys Ile Val Ser Lys
1505                1510                1515                1520
Ala Val Thr Ser Lys Lys Ser Lys Gly Glu Ser Asp Asp Phe His Met
                1525                1530                1535    
Asp Phe Asp Ser Ala Val Ala Pro Arg Ala Lys Ser Val Arg Ala Lys
            1540                1545                1550        
Lys Pro Ile Lys Tyr Leu Glu Glu Ser Asp Glu Asp Asp Leu Phe
        1555                1560                1565        


<210> 7905
<211> 113
<212> PRT
<213> Homo sapiens

<400> 7905
Met Leu Phe Asp Ile Thr Val Ser Gly Phe Met Cys Leu Gly Gly Asp
 1               5                  10                  15      
Phe Thr Cys His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Ala Glu Lys
            20                  25                  30          
Phe Asp Asp Glu Ser Val Ile Leu Lys Tyr Thr Gly Ser Gly Ile Leu
        35                  40                  45              
Ser Met Ala Asn Ala Val Leu Asn Thr Asn Gly Ser His Phe Phe Ile
    50                  55                  60                  
Cys Thr Ala Lys Thr Glu Trp Leu Val Gly Lys His Val Val Phe Gly
65                  70                  75                  80  
Lys Val Lys Ala Gly Thr Asn Lys Val Glu Ala Met Glu Cys Phe Gly
                85                  90                  95      
Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Ile Ala Asp Cys Gly Lys
            100                 105                 110         
Arg
    


<210> 7906
<211> 2299
<212> PRT
<213> Homo sapiens

<400> 7906
Met Ala Asp Arg Thr Ala Pro Arg Cys Gln Leu Arg Leu Glu Trp Val
 1               5                  10                  15      
Tyr Gly Tyr Arg Gly His Gln Cys Arg Asn Asn Leu Tyr Tyr Thr Ala
            20                  25                  30          
Gly Lys Glu Val Val Tyr Phe Val Ala Gly Val Gly Val Val Tyr Asn
        35                  40                  45              
Thr Arg Glu His Ser Gln Lys Phe Phe Leu Gly His Asn Asp Asp Ile
    50                  55                  60                  
Ile Ser Leu Ala Leu His Pro Asp Lys Thr Leu Val Ala Thr Gly Gln
65                  70                  75                  80  
Val Gly Lys Glu Pro Tyr Ile Cys Ile Trp Asp Ser Tyr Asn Val Gln
                85                  90                  95      
Thr Val Ser Leu Leu Lys Asp Val His Thr His Gly Val Ala Cys Leu
            100                 105                 110         
Ala Phe Asp Ser Asp Gly Gln Arg Leu Ala Ser Val Gly Leu Asp Ala
        115                 120                 125             
Lys Asn Thr Val Cys Ile Trp Asp Trp Arg Lys Gly Lys Leu Leu Ala
    130                 135                 140                 
Ser Ala Thr Gly His Ser Asp Arg Ile Phe Asp Ile Ser Trp Asp Pro
145                 150                 155                 160 
Tyr Gln Pro Asn Arg Val Val Ser Cys Gly Val Lys His Ile Lys Phe
                165                 170                 175     
Trp Thr Leu Cys Gly Asn Ala Leu Thr Ala Lys Arg Gly Ile Phe Gly
            180                 185                 190         
Lys Thr Gly Asp Leu Gln Thr Ile Leu Cys Leu Ala Cys Ala Lys Glu
        195                 200                 205             
Asp Ile Thr Tyr Ser Gly Ala Leu Asn Gly Asp Ile Tyr Val Trp Lys
    210                 215                 220                 
Gly Leu Asn Leu Val Arg Thr Ile Gln Gly Ala His Ser Val Ser Ile
225                 230                 235                 240 
Thr Leu Trp Lys Ser Val Gly Asp Leu Pro Asn Lys Ala Gly Ile Phe
                245                 250                 255     
Ser Met Tyr Ala Cys Glu Glu Gly Phe Ala Thr Gly Gly Arg Asp Gly
            260                 265                 270         
Cys Ile Arg Leu Trp Asp Thr Asp Phe Lys Pro Ile Thr Lys Ile Asp
        275                 280                 285             
Leu Arg Glu Thr Glu Gln Gly Tyr Lys Gly Val Val Leu Ile Thr Ser
    290                 295                 300                 
Ala Pro Gln Pro Thr Pro Ile Tyr Arg Val Arg Thr Val Ser Asp Ala
305                 310                 315                 320 
Leu Arg Tyr Thr Ser Val Ser Asp Ser Arg Pro Ile Leu Thr Lys Ile
                325                 330                 335     
Lys Ala His Leu Ala Gly Leu Ser Ile Arg Ser Val Cys Trp Lys Ala
            340                 345                 350         
Asp Arg Leu Leu Ala Gly Thr Gln Asp Ser Glu Ile Phe Glu Val Ile
        355                 360                 365             
Val Arg Glu Arg Asp Lys Pro Met Leu Ile Leu Gln Gly His Cys Glu
    370                 375                 380                 
Gly Glu Leu Trp Ala Leu Ala Leu His Pro Lys Lys Pro Leu Ala Val
385                 390                 395                 400 
Thr Gly Ser Asp Asp Arg Ser Val Arg Leu Trp Ser Leu Ala Asp His
                405                 410                 415     
Ala Leu Ile Ala Arg Cys Asn Met Glu Glu Ala Val Arg Ser Val Ala
            420                 425                 430         
Phe Ser Pro Asp Gly Ser Gln Leu Ala Leu Gly Met Lys Asp Gly Ser
        435                 440                 445             
Phe Ile Val Leu Arg Val Arg His Val Ser Ser Leu Thr Val Thr Arg
    450                 455                 460                 
Phe Leu Lys Asp Met Thr Glu Val Val His Ile Lys Asp Arg Lys Glu
465                 470                 475                 480 
Val Ile His Glu Met Lys Phe Ser Pro Asp Gly Ser Tyr Leu Ala Val
                485                 490                 495     
Gly Ser Asn Asp Gly Pro Val Asp Val Tyr Ala Val Ala Gln Arg Tyr
            500                 505                 510         
Lys Lys Ile Gly Glu Cys Ser Lys Ser Leu Ser Phe Ile Thr His Ile
        515                 520                 525             
Asp Trp Ser Leu Asp Ser Lys Tyr Leu Gln Thr Asn Asp Gly Ala Gly
    530                 535                 540                 
Glu Arg Leu Phe Tyr Arg Met Pro Ser Gly Lys Pro Leu Thr Ser Lys
545                 550                 555                 560 
Glu Glu Ile Lys Gly Ile Pro Trp Ala Ser Trp Thr Cys Val Lys Gly
                565                 570                 575     
Pro Glu Val Ser Gly Ile Trp Pro Lys Tyr Thr Glu Val Thr Asp Ile
            580                 585                 590         
Asn Ser Val Asp Ala Asn Tyr Asn Ser Ser Val Leu Val Ser Gly Asp
        595                 600                 605             
Asp Phe Gly Leu Val Lys Leu Phe Lys Phe Pro Cys Leu Lys Arg Gly
    610                 615                 620                 
Ala Lys Phe Arg Lys Tyr Val Gly His Ser Ala His Val Thr Asn Val
625                 630                 635                 640 
Arg Trp Ser His Asp Phe Gln Trp Val Leu Ser Thr Gly Gly Ala Asp
                645                 650                 655     
His Ser Val Phe Gln Trp Arg Phe Ile Pro Glu Gly Val Ser Asn Gly
            660                 665                 670         
Met Leu Glu Thr Ala Pro Gln Glu Gly Gly Ala Asp Ser Tyr Ser Glu
        675                 680                 685             
Glu Ser Asp Ser Asp Leu Ser Asp Val Pro Glu Leu Asp Ser Asp Ile
    690                 695                 700                 
Glu Gln Glu Ala Gln Ile Asn Tyr Asp Arg Gln Val Ala Pro Lys Thr
705                 710                 715                 720 
Leu Lys Tyr Ile Leu Lys Lys Asn Val Gln Val Tyr Lys Glu Asp Leu
                725                 730                 735     
Pro Gln Leu Lys Gln Gln Ser Lys Glu Lys Asn His Ala Val Pro Phe
            740                 745                 750         
Leu Lys Arg Glu Lys Ala Pro Glu Asp Ser Leu Lys Leu Gln Phe Ile
        755                 760                 765             
His Gly Tyr Arg Gly Tyr Asp Cys Arg Asn Asn Leu Phe Tyr Thr Gln
    770                 775                 780                 
Ala Gly Glu Val Val Tyr His Ile Ala Ala Val Ala Val Val Tyr Asn
785                 790                 795                 800 
Arg Gln Gln His Ser Gln Arg Leu Tyr Leu Gly His Asp Asp Asp Ile
                805                 810                 815     
Leu Ser Leu Thr Ile His Pro Val Lys Asp Tyr Val Ala Thr Gly Gln
            820                 825                 830         
Val Gly Arg Asp Ala Ala Ile His Val Trp Asp Thr Gln Thr Leu Lys
        835                 840                 845             
Cys Leu Ser Leu Leu Lys Gly Gln His Gln Arg Gly Val Cys Ala Leu
    850                 855                 860                 
Asp Phe Ser Ala Asp Gly Lys Cys Leu Val Ser Val Gly Leu Asp Asp
865                 870                 875                 880 
Phe His Ser Ile Val Phe Trp Asp Trp Lys Lys Gly Glu Lys Ile Ala
                885                 890                 895     
Thr Thr Arg Gly His Lys Asp Lys Ile Phe Val Val Lys Cys Asn Pro
            900                 905                 910         
His His Val Asp Lys Leu Val Thr Val Gly Ile Lys His Ile Lys Phe
        915                 920                 925             
Trp Gln Gln Ala Gly Gly Gly Phe Thr Ser Lys Arg Gly Thr Phe Gly
    930                 935                 940                 
Ser Val Gly Lys Leu Glu Thr Met Met Cys Val Ser Tyr Gly Arg Met
945                 950                 955                 960 
Glu Asp Leu Val Phe Ser Gly Ala Ala Thr Gly Asp Ile Phe Ile Trp
                965                 970                 975     
Lys Asp Ile Leu Leu Leu Lys Thr Val Lys Ala His Asp Gly Pro Val
            980                 985                 990         
Phe Ala Met Tyr Ala Leu Asp Lys Gly Phe Val Thr Gly Gly Lys Asp
        995                 1000                1005            
Gly Ile Val Glu Leu Trp Asp Asp Met Phe Glu Arg Cys Leu Lys Thr
    1010                1015                1020                
Tyr Ala Ile Lys Arg Ser Ala Leu Ser Thr Ser Ser Lys Gly Leu Leu
1025                1030                1035                1040
Leu Glu Asp Asn Pro Ser Ile Arg Ala Ile Thr Leu Gly His Gly His
                1045                1050                1055    
Ile Leu Val Gly Thr Lys Asn Gly Glu Ile Leu Glu Ile Asp Lys Ser
            1060                1065                1070        
Gly Pro Met Thr Leu Leu Val Gln Gly His Met Glu Gly Glu Val Trp
        1075                1080                1085            
Gly Leu Ala Ala His Pro Leu Leu Pro Ile Cys Ala Thr Val Ser Asp
    1090                1095                1100                
Asp Lys Thr Leu Arg Ile Trp Glu Leu Ser Ala Gln His Arg Met Leu
1105                1110                1115                1120
Ala Val Arg Lys Leu Lys Lys Gly Gly Arg Cys Cys Ala Phe Ser Pro
                1125                1130                1135    
Asp Gly Lys Ala Leu Ala Val Gly Leu Asn Asp Gly Ser Phe Leu Val
            1140                1145                1150        
Val Asn Ala Asp Thr Val Glu Asp Met Val Ser Phe His His Arg Lys
        1155                1160                1165            
Glu Met Ile Ser Asp Ile Lys Phe Ser Lys Asp Thr Gly Lys Tyr Leu
    1170                1175                1180                
Ala Val Ala Ser His Asp Asn Phe Val Asp Ile Tyr Asn Val Leu Thr
1185                1190                1195                1200
Ser Lys Arg Val Gly Ile Cys Lys Gly Ala Ser Ser Tyr Ile Thr His
                1205                1210                1215    
Ile Asp Trp Asp Leu Thr Gly Lys Leu Leu Gln Val Asn Ser Gly Ala
            1220                1225                1230        
Arg Glu Gln Leu Phe Phe Glu Ala Pro Arg Gly Lys Arg His Ile Ile
        1235                1240                1245            
Arg Pro Ser Glu Ile Glu Lys Ile Glu Trp Asp Thr Trp Thr Cys Val
    1250                1255                1260                
Leu Gly Pro Thr Cys Glu Gly Ile Trp Pro Ala His Ser Asp Ile Thr
1265                1270                1275                1280
Asp Val Asn Ala Ala Ser Leu Thr Lys Asp Cys Ser Leu Leu Ala Thr
                1285                1290                1295    
Gly Asp Asp Phe Gly Phe Val Lys Leu Phe Ser Tyr Pro Val Lys Gly
            1300                1305                1310        
Gln His Ala Arg Phe Lys Lys Tyr Val Gly His Ser Ala His Val Thr
        1315                1320                1325            
Asn Val Arg Trp Leu His Asn Asp Ser Val Leu Leu Thr Val Gly Gly
    1330                1335                1340                
Ala Asp Thr Ala Leu Met Ile Trp Thr Arg Glu Phe Val Gly Thr Gln
1345                1350                1355                1360
Glu Ser Lys Leu Val Asp Ser Glu Glu Ser Asp Thr Asp Val Glu Glu
                1365                1370                1375    
Asp Gly Gly Tyr Asp Ser Asp Val Ala Arg Glu Lys Ala Ile Asp Tyr
            1380                1385                1390        
Thr Thr Lys Ile Tyr Ala Val Ser Ile Arg Glu Met Glu Gly Thr Lys
        1395                1400                1405            
Pro His Gln Gln Leu Lys Glu Val Ser Val Glu Glu Arg Pro Pro Val
    1410                1415                1420                
Ser Arg Ala Ala Pro Gln Pro Glu Lys Leu Gln Lys Asn Asn Ile Thr
1425                1430                1435                1440
Lys Lys Lys Lys Leu Val Glu Glu Leu Ala Leu Asp His Val Phe Gly
                1445                1450                1455    
Tyr Arg Gly Phe Asp Cys Arg Asn Asn Leu His Tyr Leu Asn Asp Gly
            1460                1465                1470        
Ala Asp Ile Ile Phe His Thr Ala Ala Ala Gly Ile Val Gln Asn Leu
        1475                1480                1485            
Ser Thr Gly Pro Arg Glu Lys Ala Ala Met Leu Thr Pro Ala Ser Val
    1490                1495                1500                
Thr Asp Ser His Gly Glu Lys Gln Glu Thr Gly Trp Ser Gln Ser Phe
1505                1510                1515                1520
Tyr Leu Glu His Thr Asp Asp Ile Leu Cys Leu Thr Val Asn Gln His
                1525                1530                1535    
Pro Lys Tyr Arg Asn Val Val Ala Thr Ser Gln Ile Gly Thr Thr Pro
            1540                1545                1550        
Ser Ile His Ile Trp Asp Ala Met Thr Lys His Thr Leu Ser Met Leu
        1555                1560                1565            
Arg Cys Phe His Ser Lys Gly Val Asn Tyr Ile Asn Phe Ser Ala Thr
    1570                1575                1580                
Gly Lys Leu Leu Val Ser Val Gly Val Asp Pro Glu His Thr Ile Thr
1585                1590                1595                1600
Val Trp Arg Trp Gln Glu Gly Lys Pro Ala Leu Gly Phe Leu Ser Leu
                1605                1610                1615    
Gln Gly Val Cys Leu Trp Val Ser Ser Leu Trp Ala Arg Thr Gln Ile
            1620                1625                1630        
Cys Leu Thr Pro Lys Pro Ala Val Gly Thr Asp Cys Cys Trp Ala Ser
        1635                1640                1645            
Gly Lys Gln Gly Thr Gly Asp Pro Gly Ile Ala Ala Pro Leu Met Pro
    1650                1655                1660                
Val His Pro Arg Val Pro Gly Pro Gly Gly Gly Trp Pro Gly Thr Pro
1665                1670                1675                1680
Gly Pro Ile Ser Glu Gly Ala Leu Arg Arg Phe Pro Asp Val Gly Ser
                1685                1690                1695    
Pro Pro Pro Arg Lys Ala Ala Ala Ser Pro Thr Ser Val Leu Ala Thr
            1700                1705                1710        
Phe Leu Pro Lys Gly Ala Lys Val Ala Ser Arg Gly Gly His Leu Glu
        1715                1720                1725            
Arg Ile Phe Val Val Glu Phe Arg Pro Asp Ser Asp Thr Gln Phe Val
    1730                1735                1740                
Ser Val Gly Val Lys His Met Lys Phe Trp Thr Leu Ala Gly Ser Ala
1745                1750                1755                1760
Leu Leu Tyr Lys Lys Gly Val Ile Gly Ser Leu Gly Ala Ala Lys Met
                1765                1770                1775    
Gln Thr Met Leu Ser Val Ala Phe Gly Ala Asn Asn Leu Thr Phe Thr
            1780                1785                1790        
Gly Ala Ile Asn Gly Asp Val Tyr Val Trp Lys Asp His Phe Leu Ile
        1795                1800                1805            
Arg Leu Val Ala Lys Ala His Thr Gly Pro Val Phe Thr Met Tyr Thr
    1810                1815                1820                
Thr Leu Arg Asp Gly Leu Ile Val Thr Gly Gly Lys Glu Arg Pro Thr
1825                1830                1835                1840
Lys Glu Gly Gly Ala Val Lys Leu Trp Asp Gln Glu Met Lys Arg Cys
                1845                1850                1855    
Arg Ala Phe Gln Leu Glu Thr Gly Gln Leu Val Glu Cys Val Arg Ser
            1860                1865                1870        
Val Cys Arg Gly Lys Val Ser Thr Ala Ser Ser Pro Gly Gly Trp Ala
        1875                1880                1885            
Arg Glu Gly Gly Ser Val Val Phe Gln Leu Gln Gln Gly Lys Ile Leu
    1890                1895                1900                
Val Gly Thr Lys Asp Gly Glu Ile Ile Glu Val Gly Glu Lys Asn Ala
1905                1910                1915                1920
Ala Ser Asn Ile Leu Ile Asp Gly His Met Glu Gly Glu Ile Trp Gly
                1925                1930                1935    
Leu Ala Thr His Pro Ser Lys Asp Leu Phe Ile Ser Ala Ser Asn Asp
            1940                1945                1950        
Gly Thr Ala Arg Ile Trp Asp Leu Ala Asp Lys Lys Leu Leu Asn Lys
        1955                1960                1965            
Val Ser Leu Gly His Ala Ala Arg Cys Ala Ala Tyr Ser Pro Asp Gly
    1970                1975                1980                
Glu Met Val Ala Ile Gly Met Lys Asn Gly Glu Phe Val Ile Leu Leu
1985                1990                1995                2000
Val Asn Ser Leu Lys Val Trp Gly Lys Lys Arg Asp Arg Lys Ser Ala
                2005                2010                2015    
Ile Gln Asp Ile Arg Ile Ser Pro Asp Asn Arg Phe Leu Ala Val Gly
            2020                2025                2030        
Ser Ser Glu His Thr Val Asp Phe Tyr Asp Leu Thr Gln Gly Thr Asn
        2035                2040                2045            
Leu Asn Arg Ile Gly Tyr Cys Lys Asp Ile Pro Ser Phe Val Ile Gln
    2050                2055                2060                
Met Asp Phe Ser Ala Asp Gly Lys Tyr Ile Gln Val Ser Thr Gly Ala
2065                2070                2075                2080
Tyr Lys Arg Gln Val His Glu Val Pro Leu Gly Lys Gln Val Thr Glu
                2085                2090                2095    
Ala Val Val Ile Glu Lys Ile Thr Trp Ala Ser Trp Thr Ser Val Leu
            2100                2105                2110        
Gly Asp Glu Val Ile Gly Ile Trp Pro Arg Asn Ala Asp Lys Ala Asp
        2115                2120                2125            
Val Asn Cys Ala Cys Val Thr His Ala Gly Leu Asn Ile Val Thr Gly
    2130                2135                2140                
Asp Asp Phe Gly Leu Val Lys Leu Phe Asp Phe Pro Cys Thr Glu Lys
2145                2150                2155                2160
Phe Ala Lys His Lys Arg Tyr Phe Gly His Ser Ala His Val Thr Asn
                2165                2170                2175    
Ile Arg Phe Ser Tyr Asp Asp Lys Tyr Val Val Ser Thr Gly Gly Asp
            2180                2185                2190        
Asp Cys Ser Leu Leu Cys Trp Leu Leu Leu Ala Leu Ile Ala Leu Glu
        2195                2200                2205            
Ile Val Pro Pro Ala Ala Pro Cys Glu Val Leu Thr Pro Leu Gln Ser
    2210                2215                2220                
Ser Thr Asn Pro Ile Val Asn Lys Leu Gly Val Lys Asp Cys Ile Cys
2225                2230                2235                2240
Val Ala Met Ser Val Lys Cys Gln Lys Pro Leu Met Leu Leu Leu Leu
                2245                2250                2255    
Leu Leu Pro Ala Ser Asn Cys Arg Gly His Ala Glu Val Pro Pro Cys
            2260                2265                2270        
His Gln Pro Leu Gly Asn Ala Tyr His Ala Ala Pro Asp Ala Gln Ala
        2275                2280                2285            
Gln Asn Ala Ala Glu Val Thr Gln Leu Leu Pro
    2290                2295                


<210> 7907
<211> 5147
<212> PRT
<213> Homo sapiens

<400> 7907
Ile Pro Ala Gly Met Glu Ala Asp Leu Ser Gln Leu Ser Glu Glu Glu
 1               5                  10                  15      
Arg Arg Gln Ile Ala Ala Val Met Ser Arg Ala Gln Gly Leu Pro Lys
            20                  25                  30          
Gly Ser Val Pro Pro Ala Ala Ala Glu Ser Pro Ser Met His Arg Lys
        35                  40                  45              
Gln Glu Leu Asp Ser Ser His Pro Pro Lys Gln Ser Gly Arg Pro Pro
    50                  55                  60                  
Asp Pro Gly Arg Pro Ala Gln Pro Gly Leu Ser Lys Ser Arg Thr Thr
65                  70                  75                  80  
Asp Thr Phe Arg Ser Glu Gln Lys Leu Pro Gly Arg Ser Pro Ser Thr
                85                  90                  95      
Ile Ser Leu Lys Glu Ser Lys Ser Arg Thr Asp Leu Lys Glu Glu His
            100                 105                 110         
Lys Ser Ser Met Met Pro Gly Phe Leu Ser Glu Val Asn Ala Leu Ser
        115                 120                 125             
Ala Val Ser Ser Val Val Asn Lys Phe Asn Pro Phe Asp Leu Ile Ser
    130                 135                 140                 
Asp Ser Glu Ala Ser Gln Glu Glu Thr Thr Lys Lys Gln Lys Val Val
145                 150                 155                 160 
Gln Lys Glu Gln Gly Lys Pro Glu Gly Ile Ile Lys Pro Pro Leu Gln
                165                 170                 175     
Gln Gln Pro Pro Lys Pro Ile Pro Lys Gln Gln Gly Pro Gly Arg Asp
            180                 185                 190         
Pro Leu Gln Gln Asp Gly Thr Pro Lys Ser Ile Ser Ser Gln Gln Pro
        195                 200                 205             
Glu Lys Ile Lys Ser Gln Pro Pro Gly Thr Gly Lys Pro Ile Gln Gly
    210                 215                 220                 
Pro Thr Gln Thr Pro Gln Thr Asp His Ala Lys Leu Pro Leu Gln Arg
225                 230                 235                 240 
Asp Ala Ser Arg Pro Gln Thr Lys Gln Ala Asp Ile Val Arg Gly Glu
                245                 250                 255     
Ser Val Lys Pro Ser Leu Pro Ser Pro Ser Lys Pro Pro Ile Gln Gln
            260                 265                 270         
Pro Thr Pro Gly Lys Pro Pro Ala Gln Gln Pro Gly His Glu Lys Ser
        275                 280                 285             
Gln Pro Gly Pro Ala Lys Pro Pro Ala Gln Pro Ser Gly Leu Thr Lys
    290                 295                 300                 
Pro Leu Ala Gln Gln Pro Gly Thr Val Lys Pro Pro Val Gln Pro Pro
305                 310                 315                 320 
Gly Thr Thr Lys Pro Pro Ala Gln Pro Leu Gly Pro Ala Lys Pro Pro
                325                 330                 335     
Ala Gln Gln Thr Gly Ser Glu Lys Pro Ser Ser Glu Gln Pro Gly Pro
            340                 345                 350         
Lys Ala Leu Ala Gln Pro Pro Gly Val Gly Lys Thr Pro Ala Gln Gln
        355                 360                 365             
Pro Gly Pro Ala Lys Pro Pro Thr Gln Gln Val Gly Thr Pro Lys Pro
    370                 375                 380                 
Leu Ala Gln Gln Pro Gly Leu Gln Ser Pro Ala Lys Ala Pro Gly Pro
385                 390                 395                 400 
Thr Lys Thr Pro Ala Gln Thr Lys Pro Pro Ser Gln Gln Pro Gly Ser
                405                 410                 415     
Thr Lys Pro Pro Pro Gln Gln Pro Gly Pro Ala Lys Pro Ser Pro Gln
            420                 425                 430         
Gln Pro Gly Ser Thr Lys Pro Pro Ser Gln Gln Pro Gly Ser Ala Lys
        435                 440                 445             
Pro Ser Ala Gln Gln Pro Ser Pro Ala Lys Pro Ser Ala Gln Gln Phe
    450                 455                 460                 
Thr Lys Pro Val Ser Gln Thr Gly Phe Gly Lys Pro Leu Gln Pro Pro
465                 470                 475                 480 
Thr Val Ser Pro Ser Ala Lys Gln Pro Pro Ser Gln Gly Leu Pro Lys
                485                 490                 495     
Thr Ile Cys Pro Leu Cys Asn Thr Thr Glu Leu Leu Leu His Val Pro
            500                 505                 510         
Glu Lys Ala Asn Phe Asn Thr Cys Thr Glu Cys Gln Thr Thr Val Cys
        515                 520                 525             
Ser Leu Cys Gly Phe Asn Pro Asn Pro His Leu Thr Glu Ala Lys Glu
    530                 535                 540                 
Trp Leu Cys Leu Asn Cys Gln Met Lys Arg Ala Leu Gly Gly Asp Leu
545                 550                 555                 560 
Ala Pro Val Pro Ser Ser Pro Gln Pro Lys Leu Lys Thr Ala Pro Val
                565                 570                 575     
Thr Thr Thr Ser Ala Val Ser Lys Ser Ser Pro Gln Pro Gln Gln Thr
            580                 585                 590         
Ser Pro Lys Lys Asp Ala Ala Pro Lys Gln Asp Leu Ser Lys Ala Pro
        595                 600                 605             
Glu Pro Lys Lys Pro Pro Pro Leu Val Lys Gln Pro Thr Leu His Gly
    610                 615                 620                 
Ser Pro Ser Ala Lys Ala Lys Gln Pro Pro Glu Ala Asp Ser Leu Ser
625                 630                 635                 640 
Lys Pro Ala Pro Pro Lys Glu Pro Ser Val Pro Ser Glu Gln Asp Lys
                645                 650                 655     
Ala Pro Val Ala Asp Asp Lys Pro Lys Gln Pro Lys Met Val Lys Pro
            660                 665                 670         
Thr Thr Asp Leu Val Ser Ser Ser Ser Ala Thr Thr Lys Pro Asp Ile
        675                 680                 685             
Pro Ser Ser Lys Val Gln Ser Gln Ala Glu Glu Lys Thr Thr Pro Pro
    690                 695                 700                 
Leu Lys Thr Asp Ser Ala Lys Pro Ser Gln Ser Phe Pro Pro Thr Gly
705                 710                 715                 720 
Glu Lys Val Thr Pro Phe Asp Ser Lys Ala Ile Pro Arg Pro Ala Ser
                725                 730                 735     
Asp Ser Lys Ile Ile Ser His Pro Gly Pro Ser Ser Glu Ser Lys Gly
            740                 745                 750         
Gln Lys Gln Val Asp Pro Val Gln Lys Lys Glu Glu Pro Lys Lys Ala
        755                 760                 765             
Gln Thr Lys Met Ser Pro Lys Pro Asp Ala Lys Pro Met Pro Lys Gly
    770                 775                 780                 
Ser Pro Thr Pro Pro Gly Pro Arg Pro Thr Ala Gly Gln Thr Val Pro
785                 790                 795                 800 
Thr Pro Gln Gln Ser Pro Lys Pro Gln Glu Gln Ser Arg Arg Phe Ser
                805                 810                 815     
Leu Asn Leu Gly Ser Ile Thr Asp Ala Pro Lys Ser Gln Pro Thr Thr
            820                 825                 830         
Pro Gln Glu Thr Val Thr Gly Lys Leu Phe Gly Phe Gly Ala Ser Ile
        835                 840                 845             
Phe Ser Gln Ala Ser Asn Leu Ile Ser Thr Ala Gly Gln Pro Gly Pro
    850                 855                 860                 
His Ser Gln Ser Gly Pro Gly Ala Pro Met Lys Gln Ala Pro Ala Pro
865                 870                 875                 880 
Ser Gln Pro Pro Thr Ser Gln Gly Pro Pro Lys Ser Thr Gly Gln Ala
                885                 890                 895     
Pro Pro Ala Pro Ala Lys Ser Ile Pro Val Lys Lys Glu Thr Lys Ala
            900                 905                 910         
Pro Ala Ala Glu Lys Leu Glu Pro Lys Ala Glu Gln Ala Pro Thr Val
        915                 920                 925             
Lys Arg Thr Glu Thr Glu Lys Lys Pro Pro Pro Ile Lys Asp Ser Lys
    930                 935                 940                 
Ser Leu Thr Ala Glu Pro Gln Lys Ala Val Leu Pro Thr Lys Leu Glu
945                 950                 955                 960 
Lys Ser Pro Lys Pro Glu Ser Thr Cys Pro Leu Cys Lys Thr Glu Leu
                965                 970                 975     
Asn Ile Gly Ser Lys Asp Pro Pro Asn Phe Asn Thr Cys Thr Glu Cys
            980                 985                 990         
Lys Asn Gln Val Cys Asn Leu Cys Gly Phe Asn Pro Thr Pro His Leu
        995                 1000                1005            
Thr Glu Asn Cys Gln Thr Gln Arg Ala Ile Ser Gly Gln Leu Gly Asp
    1010                1015                1020                
Ile Arg Lys Met Pro Pro Ala Pro Ser Gly Pro Lys Ala Ser Pro Met
1025                1030                1035                1040
Pro Val Pro Thr Glu Ser Ser Ser Gln Lys Thr Ala Val Pro Pro Gln
                1045                1050                1055    
Val Lys Leu Val Lys Lys Gln Glu Gln Glu Val Lys Thr Glu Ala Glu
            1060                1065                1070        
Lys Val Ile Leu Glu Lys Val Lys Glu Thr Leu Ser Met Glu Lys Ile
        1075                1080                1085            
Pro Pro Met Val Thr Thr Asp Gln Lys Gln Glu Glu Ser Lys Leu Glu
    1090                1095                1100                
Lys Asp Lys Ala Ser Ala Leu Gln Glu Lys Lys Pro Leu Pro Glu Glu
1105                1110                1115                1120
Lys Lys Leu Ile Pro Glu Glu Glu Lys Ile Arg Ser Glu Glu Lys Lys
                1125                1130                1135    
Pro Leu Leu Glu Glu Lys Lys Pro Thr Pro Glu Asp Lys Lys Leu Leu
            1140                1145                1150        
Pro Glu Ala Lys Thr Ser Ala Pro Glu Glu Gln Lys His Asp Leu Leu
        1155                1160                1165            
Lys Ser Gln Val Gln Ile Ala Glu Glu Lys Leu Glu Gly Arg Val Ala
    1170                1175                1180                
Pro Lys Thr Val Gln Glu Gly Lys Gln Pro Gln Thr Lys Met Glu Gly
1185                1190                1195                1200
Leu Pro Ser Gly Thr Pro Gln Ser Leu Pro Lys Glu Asp Asp Lys Thr
                1205                1210                1215    
Thr Lys Thr Ile Lys Glu Gln Pro Gln Pro Pro Cys Thr Ala Lys Pro
            1220                1225                1230        
Asp Gln Glu Lys Glu Asp Asp Lys Ser Asp Thr Ser Ser Ser Gln Gln
        1235                1240                1245            
Pro Lys Ser Pro Gln Gly Leu Ser Asp Thr Gly Tyr Ser Ser Asp Gly
    1250                1255                1260                
Ile Ser Ser Ser Leu Gly Glu Ile Pro Ser Leu Ile Pro Thr Asp Glu
1265                1270                1275                1280
Lys Asp Ile Leu Lys Gly Leu Lys Lys Asp Ser Phe Ser Gln Glu Ser
                1285                1290                1295    
Ser Pro Ser Ser Pro Ser Asp Leu Ala Lys Leu Glu Ser Thr Val Leu
            1300                1305                1310        
Ser Ile Leu Glu Ala Gln Ala Ser Thr Leu Ala Asp Glu Lys Ser Glu
        1315                1320                1325            
Lys Lys Thr Gln Pro His Glu Val Ser Pro Glu Gln Pro Lys Asp Gln
    1330                1335                1340                
Glu Lys Thr Gln Ser Leu Ser Glu Thr Leu Glu Ile Thr Ile Ser Glu
1345                1350                1355                1360
Glu Glu Ile Lys Glu Ser Gln Glu Glu Arg Lys Asp Thr Phe Lys Lys
                1365                1370                1375    
Asp Ser Gln Gln Asp Ile Pro Ser Ser Lys Asp His Lys Glu Lys Ser
            1380                1385                1390        
Glu Phe Val Asp Asp Ile Thr Thr Arg Arg Glu Pro Tyr Asp Ser Val
        1395                1400                1405            
Glu Glu Ser Ser Glu Ser Glu Asn Ser Pro Val Pro Gln Arg Lys Arg
    1410                1415                1420                
Arg Thr Ser Val Gly Ser Ser Ser Ser Asp Glu Tyr Lys Gln Glu Asp
1425                1430                1435                1440
Ser Gln Gly Ser Gly Glu Glu Glu Asp Phe Ile Arg Lys Gln Ile Ile
                1445                1450                1455    
Glu Met Ser Ala Asp Glu Asp Ala Ser Gly Ser Glu Asp Asp Glu Phe
            1460                1465                1470        
Ile Arg Asn Gln Leu Lys Glu Ile Ser Ser Ser Thr Glu Ser Gln Lys
        1475                1480                1485            
Lys Glu Glu Thr Lys Gly Lys Gly Lys Ile Thr Ala Gly Lys His Arg
    1490                1495                1500                
Arg Leu Thr Arg Lys Ser Ser Thr Ser Ile Asp Glu Asp Ala Gly Arg
1505                1510                1515                1520
Arg His Ser Trp His Asp Glu Asp Asp Glu Ala Phe Asp Glu Ser Pro
                1525                1530                1535    
Glu Leu Lys Tyr Arg Glu Thr Lys Ser Gln Glu Ser Glu Glu Leu Val
            1540                1545                1550        
Val Thr Gly Gly Gly Gly Leu Arg Arg Phe Lys Thr Ile Glu Leu Asn
        1555                1560                1565            
Ser Thr Ile Ala Asp Lys Tyr Ser Ala Glu Ser Ser Gln Lys Lys Thr
    1570                1575                1580                
Ser Leu Tyr Phe Asp Glu Glu Pro Glu Leu Glu Met Glu Ser Leu Thr
1585                1590                1595                1600
Asp Ser Pro Glu Asp Arg Ser Arg Gly Glu Gly Ser Ser Ser Leu His
                1605                1610                1615    
Ala Ser Ser Phe Thr Pro Gly Thr Ser Pro Thr Ser Val Ser Ser Leu
            1620                1625                1630        
Asp Glu Asp Ser Asp Ser Ser Pro Ser His Lys Lys Gly Glu Ser Lys
        1635                1640                1645            
Gln Gln Arg Lys Ala Arg His Arg Pro His Gly Pro Leu Leu Pro Thr
    1650                1655                1660                
Ile Glu Asp Ser Ser Glu Glu Glu Glu Leu Arg Glu Glu Glu Glu Leu
1665                1670                1675                1680
Leu Lys Glu Gln Glu Lys Gln Arg Glu Ile Glu Gln Gln Gln Arg Lys
                1685                1690                1695    
Ser Ser Ser Lys Lys Ser Lys Lys Asp Lys Asp Glu Leu Arg Ala Gln
            1700                1705                1710        
Arg Arg Arg Glu Arg Pro Lys Thr Pro Pro Ser Asn Leu Ser Pro Ile
        1715                1720                1725            
Glu Asp Ala Ser Pro Thr Glu Glu Leu Arg Gln Ala Ala Glu Met Glu
    1730                1735                1740                
Glu Leu His Arg Ser Ser Cys Ser Glu Tyr Ser Pro Ser Ile Glu Ser
1745                1750                1755                1760
Asp Pro Glu Gly Phe Glu Ile Ser Pro Glu Lys Ile Ile Glu Val Gln
                1765                1770                1775    
Lys Val Tyr Lys Leu Pro Thr Ala Val Ser Leu Tyr Ser Pro Thr Asp
            1780                1785                1790        
Glu Gln Ser Ile Met Gln Lys Glu Gly Ser Gln Lys Ala Leu Lys Ser
        1795                1800                1805            
Ala Glu Glu Met Tyr Glu Glu Met Met His Lys Thr His Lys Tyr Lys
    1810                1815                1820                
Ala Phe Pro Ala Ala Asn Glu Arg Asp Glu Val Phe Glu Lys Glu Pro
1825                1830                1835                1840
Leu Tyr Gly Gly Met Leu Ile Glu Asp Tyr Ile Tyr Glu Ser Leu Val
                1845                1850                1855    
Glu Asp Thr Tyr Asn Gly Ser Val Asp Gly Ser Leu Leu Thr Arg Gln
            1860                1865                1870        
Glu Glu Glu Asn Gly Phe Met Gln Gln Lys Gly Arg Glu Gln Lys Ile
        1875                1880                1885            
Arg Leu Ser Glu Gln Ile Tyr Glu Asp Pro Met Gln Lys Ile Thr Asp
    1890                1895                1900                
Leu Gln Lys Glu Phe Tyr Glu Leu Glu Ser Leu His Ser Val Val Pro
1905                1910                1915                1920
Gln Glu Asp Ile Val Ser Ser Ser Phe Ile Ile Pro Glu Ser His Glu
                1925                1930                1935    
Ile Val Asp Leu Gly Thr Met Val Thr Ser Thr Glu Glu Glu Arg Lys
            1940                1945                1950        
Leu Leu Asp Ala Asp Ala Ala Tyr Glu Glu Leu Met Lys Arg Gln Gln
        1955                1960                1965            
Met Gln Leu Thr Pro Gly Ser Ser Pro Thr Gln Ala Pro Ile Gly Glu
    1970                1975                1980                
Asp Met Thr Glu Ser Thr Met Asp Phe Asp Arg Met Pro Asp Ala Ser
1985                1990                1995                2000
Leu Thr Ser Ser Val Leu Ser Gly Ala Ser Leu Thr Asp Ser Thr Ser
                2005                2010                2015    
Ser Ala Thr Leu Ser Ile Pro Asp Val Lys Ile Thr Gln His Phe Ser
            2020                2025                2030        
Thr Glu Glu Ile Glu Asp Glu Tyr Val Thr Asp Tyr Thr Arg Glu Ile
        2035                2040                2045            
Gln Glu Ile Ile Ala His Glu Ser Leu Ile Leu Thr Tyr Ser Glu Pro
    2050                2055                2060                
Ser Glu Ser Ala Thr Ser Val Pro Pro Ser Asp Thr Pro Ser Leu Thr
2065                2070                2075                2080
Ser Ser Val Ser Ser Val Cys Thr Thr Asp Ser Ser Ser Pro Ile Thr
                2085                2090                2095    
Thr Leu Asp Ser Ile Thr Thr Val Tyr Thr Glu Pro Val Asp Met Ile
            2100                2105                2110        
Thr Lys Phe Glu Asp Ser Glu Glu Ile Ser Ser Ser Thr Tyr Phe Pro
        2115                2120                2125            
Gly Ser Ile Ile Asp Tyr Pro Glu Glu Ile Ser Val Ser Leu Asp Arg
    2130                2135                2140                
Thr Ala Pro Pro Asp Gly Arg Ala Ser Ala Asp His Ile Val Ile Ser
2145                2150                2155                2160
Leu Ser Asp Met Ala Ser Ser Ile Ile Glu Ser Val Val Pro Lys Pro
                2165                2170                2175    
Glu Gly Pro Val Ala Asp Thr Val Ser Thr Asp Leu Leu Ile Ser Glu
            2180                2185                2190        
Lys Asp Pro Val Lys Lys Ala Lys Lys Glu Thr Gly Asn Gly Ile Ile
        2195                2200                2205            
Leu Glu Val Leu Glu Ala Tyr Arg Asp Lys Lys Glu Leu Glu Ala Glu
    2210                2215                2220                
Arg Thr Lys Ser Ser Leu Ser Glu Thr Val Phe Asp His Pro Pro Ser
2225                2230                2235                2240
Ser Val Ile Ala Leu Pro Met Lys Glu Gln Leu Ser Thr Thr Tyr Phe
                2245                2250                2255    
Thr Ser Gly Glu Thr Phe Gly Gln Glu Lys Pro Ala Ser Gln Leu Pro
            2260                2265                2270        
Ser Gly Ser Pro Ser Val Ser Ser Leu Pro Ala Lys Pro Arg Pro Phe
        2275                2280                2285            
Phe Arg Ser Ser Ser Leu Asp Ile Ser Ala Gln Pro Pro Pro Pro Pro
    2290                2295                2300                
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
2305                2310                2315                2320
Pro Leu Pro Pro Pro Thr Ser Pro Lys Pro Thr Ile Leu Pro Lys Lys
                2325                2330                2335    
Lys Leu Thr Val Ala Ser Pro Val Thr Thr Ala Thr Pro Leu Phe Asp
            2340                2345                2350        
Ala Val Thr Thr Leu Glu Thr Thr Ala Val Leu Arg Ser Asn Gly Leu
        2355                2360                2365            
Pro Val Thr Arg Ile Cys Thr Thr Ala Pro Pro Pro Val Pro Pro Lys
    2370                2375                2380                
Pro Ser Ser Ile Pro Ser Gly Leu Val Phe Thr His Arg Pro Glu Pro
2385                2390                2395                2400
Ser Lys Pro Pro Ile Ala Pro Lys Pro Val Ile Pro Gln Leu Pro Thr
                2405                2410                2415    
Thr Thr Gln Lys Pro Thr Asp Ile His Pro Lys Pro Thr Gly Leu Ser
            2420                2425                2430        
Leu Thr Ser Ser Met Thr Leu Asn Leu Val Thr Ser Ala Asp Tyr Lys
        2435                2440                2445            
Leu Pro Ser Pro Thr Ser Pro Leu Ser Pro His Ser Asn Lys Ser Ser
    2450                2455                2460                
Pro Arg Phe Ser Lys Ser Leu Thr Glu Thr Tyr Val Val Ile Thr Leu
2465                2470                2475                2480
Pro Ser Glu Pro Gly Thr Pro Thr Asp Ser Ser Ala Ser Gln Ala Ile
                2485                2490                2495    
Thr Ser Trp Pro Leu Gly Ser Pro Ser Lys Asp Leu Val Ser Val Glu
            2500                2505                2510        
Pro Val Phe Ser Val Val Pro Pro Val Thr Ala Val Glu Ile Pro Ile
        2515                2520                2525            
Ser Ser Glu Gln Thr Phe Tyr Ile Ser Gly Ala Leu Gln Thr Phe Ser
    2530                2535                2540                
Ala Thr Pro Val Thr Ala Pro Ser Ser Phe Gln Ala Ala Pro Thr Ser
2545                2550                2555                2560
Val Thr Gln Phe Leu Thr Thr Glu Val Ser Lys Thr Glu Val Ser Ala
                2565                2570                2575    
Thr Arg Ser Thr Ala Pro Ser Val Gly Leu Ser Ser Ile Ser Ile Thr
            2580                2585                2590        
Ile Pro Pro Glu Pro Leu Ala Leu Asp Asn Ile His Leu Glu Lys Pro
        2595                2600                2605            
Gln Tyr Lys Glu Asp Gly Lys Leu Gln Leu Val Gly Asp Val Ile Asp
    2610                2615                2620                
Leu Arg Thr Val Pro Lys Val Glu Val Lys Thr Thr Asp Lys Cys Ile
2625                2630                2635                2640
Asp Leu Ser Ala Ser Thr Met Asp Val Lys Arg Gln Ile Thr Ala Asn
                2645                2650                2655    
Glu Val Tyr Gly Lys Gln Ile Ser Ala Val Gln Pro Ser Ile Ile Asn
            2660                2665                2670        
Leu Ser Val Thr Ser Ser Ile Val Thr Pro Val Ser Leu Ala Thr Glu
        2675                2680                2685            
Thr Val Thr Phe Val Thr Cys Thr Ala Ser Ala Ser Tyr Thr Thr Gly
    2690                2695                2700                
Thr Glu Ser Leu Val Gly Ala Glu His Ala Met Thr Thr Pro Leu Gln
2705                2710                2715                2720
Leu Thr Thr Ser Lys His Ala Glu Pro Pro Tyr Arg Ile Pro Ser Asp
                2725                2730                2735    
Gln Val Phe Pro Ile Ala Arg Glu Glu Ala Pro Ile Asn Leu Ser Leu
            2740                2745                2750        
Gly Thr Pro Ala His Ala Val Thr Leu Ala Ile Thr Lys Pro Val Thr
        2755                2760                2765            
Val Pro Pro Val Gly Val Thr Asn Gly Trp Thr Asp Ser Thr Val Ser
    2770                2775                2780                
Gln Gly Ile Thr Asp Gly Glu Val Val Asp Leu Ser Thr Thr Lys Ser
2785                2790                2795                2800
His Arg Thr Val Val Thr Met Asp Glu Ser Thr Ser Ser Val Met Thr
                2805                2810                2815    
Lys Ile Ile Glu Asp Glu Lys Pro Val Asp Leu Thr Ala Gly Arg Arg
            2820                2825                2830        
Ala Val Cys Cys Asp Val Val Tyr Lys Leu Pro Phe Gly Arg Ser Cys
        2835                2840                2845            
Thr Ala Gln Gln Pro Ala Thr Thr Leu Pro Glu Asp Arg Phe Gly Tyr
    2850                2855                2860                
Arg Asp Asp His Tyr Gln Tyr Asp Arg Ser Gly Pro Tyr Gly Tyr Arg
2865                2870                2875                2880
Gly Ile Gly Gly Met Lys Pro Ser Met Ser Asp Thr Asn Leu Ala Glu
                2885                2890                2895    
Ala Gly His Phe Phe Tyr Lys Ser Lys Asn Ala Phe Asp Tyr Ser Glu
            2900                2905                2910        
Gly Thr Asp Thr Ala Val Asp Leu Thr Ser Gly Arg Val Thr Thr Gly
        2915                2920                2925            
Glu Val Met Asp Tyr Ser Ser Lys Thr Thr Gly Pro Tyr Pro Glu Thr
    2930                2935                2940                
Arg Gln Val Ile Ser Gly Ala Gly Ile Ser Thr Pro Gln Tyr Ser Thr
2945                2950                2955                2960
Ala Arg Met Thr Pro Pro Pro Gly Pro Gln Tyr Cys Val Gly Ser Val
                2965                2970                2975    
Leu Arg Ser Ser Asn Gly Val Val Tyr Ser Ser Val Ala Thr Pro Thr
            2980                2985                2990        
Pro Ser Thr Phe Ala Ile Thr Thr Gln Pro Gly Ser Ile Phe Ser Thr
        2995                3000                3005            
Thr Val Arg Asp Leu Ser Gly Ile His Thr Ala Asp Ala Val Thr Ser
    3010                3015                3020                
Leu Pro Ala Met His His Ser Gln Pro Met Pro Arg Ser Tyr Phe Ile
3025                3030                3035                3040
Thr Thr Gly Ala Ser Glu Thr Asp Ile Ala Val Thr Gly Ile Asp Ile
                3045                3050                3055    
Ser Ala Ser Leu Gln Thr Ile Thr Met Glu Ser Leu Thr Ala Glu Thr
            3060                3065                3070        
Ile Asp Ser Val Pro Thr Leu Thr Thr Ala Ser Glu Val Phe Pro Glu
        3075                3080                3085            
Val Val Gly Asp Glu Ser Ala Leu Leu Ile Val Pro Glu Glu Asp Lys
    3090                3095                3100                
Gln Gln Gln Gln Leu Asp Leu Glu Arg Glu Leu Leu Glu Leu Glu Lys
3105                3110                3115                3120
Ile Lys Gln Gln Arg Phe Ala Glu Glu Leu Glu Trp Glu Arg Gln Glu
                3125                3130                3135    
Ile Gln Arg Phe Arg Glu Gln Glu Lys Ile Met Val Gln Lys Lys Leu
            3140                3145                3150        
Glu Glu Leu Gln Ser Met Lys Gln His Leu Leu Phe Gln Gln Glu Glu
        3155                3160                3165            
Glu Arg Gln Ala Gln Phe Met Met Arg Gln Glu Thr Leu Ala Gln Gln
    3170                3175                3180                
Gln Leu Gln Leu Glu Gln Ile Gln Gln Leu Gln Gln Gln Leu His Gln
3185                3190                3195                3200
Gln Leu Glu Glu Gln Lys Ile Arg Gln Ile Tyr Gln Tyr Asn Tyr Asp
                3205                3210                3215    
Pro Ser Gly Thr Ala Ser Pro Gln Thr Thr Thr Glu Gln Ala Ile Leu
            3220                3225                3230        
Glu Gly Gln Tyr Ala Ala Leu Glu Gly Ser Gln Phe Trp Ala Thr Glu
        3235                3240                3245            
Asp Ala Thr Thr Thr Ala Ser Ala Val Val Ala Ile Glu Ile Pro Gln
    3250                3255                3260                
Ser Gln Gly Trp Tyr Thr Val Gln Ser Asp Gly Val Thr Gln Tyr Ile
3265                3270                3275                3280
Ala Pro Pro Gly Ile Leu Ser Thr Val Ser Glu Ile Pro Leu Thr Asp
                3285                3290                3295    
Val Val Val Lys Glu Glu Lys Gln Pro Lys Lys Arg Ser Ser Gly Ala
            3300                3305                3310        
Lys Val Arg Gly Gln Tyr Asp Asp Met Gly Glu Asn Met Thr Asp Asp
        3315                3320                3325            
Pro Arg Ser Phe Lys Lys Ile Val Asp Ser Gly Val Gln Thr Asp Asp
    3330                3335                3340                
Glu Asp Ala Thr Asp Arg Ser Tyr Val Ser Arg Arg Arg Arg Thr Lys
3345                3350                3355                3360
Lys Ser Val Asp Thr Ser Val Gln Thr Asp Asp Glu Asp Gln Asp Glu
                3365                3370                3375    
Trp Asp Met Pro Thr Arg Ser Arg Arg Lys Ala Arg Val Gly Lys Tyr
            3380                3385                3390        
Gly Asp Ser Met Thr Glu Ala Asp Lys Thr Lys Pro Leu Ser Lys Val
        3395                3400                3405            
Ser Ser Ile Ala Val Gln Thr Val Ala Glu Ile Ser Val Gln Thr Glu
    3410                3415                3420                
Pro Val Gly Thr Ile Arg Thr Pro Ser Ile Arg Ala Arg Val Asp Ala
3425                3430                3435                3440
Lys Val Glu Ile Ile Lys His Ile Ser Ala Pro Glu Lys Thr Tyr Lys
                3445                3450                3455    
Gly Gly Ser Leu Gly Cys Gln Thr Glu Ala Asp Ser Asp Thr Gln Ser
            3460                3465                3470        
Pro Gln Tyr Leu Ser Ala Thr Ser Pro Pro Lys Asp Lys Lys Arg Pro
        3475                3480                3485            
Thr Pro Leu Glu Ile Gly Tyr Ser Ser His Leu Arg Ala Asp Ser Thr
    3490                3495                3500                
Val Gln Leu Ala Pro Ser Pro Pro Lys Ser Pro Lys Val Leu Tyr Ser
3505                3510                3515                3520
Pro Ile Ser Pro Leu Ser Pro Gly Lys Ala Leu Glu Ser Ala Phe Val
                3525                3530                3535    
Pro Tyr Glu Lys Pro Leu Pro Asp Asp Ile Ser Pro Gln Lys Val Leu
            3540                3545                3550        
His Pro Asp Met Ala Lys Val Pro Pro Ala Ser Pro Lys Thr Ala Lys
        3555                3560                3565            
Met Met Gln Arg Ser Met Ser Asp Pro Lys Pro Leu Ser Pro Thr Ala
    3570                3575                3580                
Asp Glu Ser Ser Arg Ala Pro Phe Gln Tyr Thr Glu Gly Tyr Thr Thr
3585                3590                3595                3600
Lys Gly Ser Gln Thr Met Thr Ser Ser Gly Ala Gln Lys Lys Val Lys
                3605                3610                3615    
Arg Thr Leu Pro Asn Pro Pro Pro Glu Glu Ile Ser Thr Gly Thr Gln
            3620                3625                3630        
Ser Thr Phe Ser Thr Met Gly Thr Val Ser Arg Arg Arg Ile Cys Arg
        3635                3640                3645            
Thr Asn Thr Met Ala Arg Ala Lys Ile Leu Gln Asp Ile Asp Arg Glu
    3650                3655                3660                
Leu Asp Leu Val Glu Arg Glu Ser Ala Lys Leu Arg Lys Lys Gln Ala
3665                3670                3675                3680
Glu Leu Asp Glu Glu Glu Lys Glu Ile Asp Ala Lys Leu Arg Tyr Leu
                3685                3690                3695    
Glu Met Gly Ile Asn Arg Arg Lys Glu Ala Leu Leu Lys Glu Arg Glu
            3700                3705                3710        
Lys Arg Glu Arg Ala Tyr Leu Gln Gly Val Ala Glu Asp Arg Asp Tyr
        3715                3720                3725            
Met Ser Asp Ser Glu Val Ser Ser Thr Arg Pro Thr Arg Ile Glu Ser
    3730                3735                3740                
Gln His Gly Ile Glu Arg Pro Arg Thr Ala Pro Gln Thr Glu Phe Ser
3745                3750                3755                3760
Gln Phe Ile Pro Pro Gln Thr Gln Thr Glu Ser Gln Leu Val Pro Pro
                3765                3770                3775    
Thr Ser Pro Tyr Thr Gln Tyr Gln Tyr Ser Ser Pro Ala Leu Pro Thr
            3780                3785                3790        
Gln Ala Pro Thr Ser Tyr Thr Gln Gln Ser His Phe Glu Gln Gln Thr
        3795                3800                3805            
Leu Tyr His Gln Gln Val Ser Pro Tyr Gln Thr Gln Pro Thr Phe Gln
    3810                3815                3820                
Ala Val Ala Thr Met Ser Phe Thr Pro Gln Val Gln Pro Thr Pro Thr
3825                3830                3835                3840
Pro Gln Pro Ser Tyr Gln Leu Pro Ser Gln Met Met Val Ile Gln Gln
                3845                3850                3855    
Lys Pro Arg Gln Thr Thr Leu Tyr Leu Glu Pro Lys Ile Thr Ser Asn
            3860                3865                3870        
Tyr Glu Val Ile Arg Asn Gln Pro Leu Met Ile Ala Pro Val Ser Thr
        3875                3880                3885            
Asp Asn Thr Phe Ala Val Ser His Leu Gly Ser Lys Tyr Asn Ser Leu
    3890                3895                3900                
Asp Leu Arg Ile Gly Leu Glu Glu Arg Ser Ser Met Ala Ser Ser Pro
3905                3910                3915                3920
Ile Ser Ser Ile Ser Ala Asp Ser Phe Tyr Ala Asp Ile Asp His His
                3925                3930                3935    
Thr Pro Arg Asn Tyr Val Leu Ile Asp Asp Ile Gly Glu Ile Thr Lys
            3940                3945                3950        
Gly Thr Ala Ala Leu Ser Thr Ala Phe Ser Leu His Glu Lys Asp Leu
        3955                3960                3965            
Ser Lys Thr Asp Arg Leu Leu Arg Thr Thr Glu Thr Arg Arg Ser Gln
    3970                3975                3980                
Glu Val Thr Asp Phe Leu Ala Pro Leu Gln Ser Ser Ser Arg Leu His
3985                3990                3995                4000
Ser Tyr Val Lys Ala Glu Glu Asp Pro Met Glu Asp Pro Tyr Glu Leu
                4005                4010                4015    
Lys Leu Leu Lys His Gln Ile Lys Gln Glu Phe Arg Arg Gly Thr Glu
            4020                4025                4030        
Ser Leu Asp His Leu Ala Gly Leu Ser His Tyr Tyr His Ala Asp Thr
        4035                4040                4045            
Ser Tyr Arg His Phe Pro Lys Ser Glu Lys Tyr Ser Ile Ser Arg Leu
    4050                4055                4060                
Thr Leu Glu Lys Gln Ala Ala Lys Gln Leu Pro Ala Ala Ile Leu Tyr
4065                4070                4075                4080
Gln Lys Gln Ser Lys His Lys Lys Ser Leu Ile Asp Pro Lys Met Ser
                4085                4090                4095    
Lys Phe Ser Pro Ile Gln Glu Ser Arg Asp Leu Glu Pro Asp Tyr Ser
            4100                4105                4110        
Ser Tyr Met Thr Ser Ser Thr Ser Ser Ile Gly Gly Ile Ser Ser Arg
        4115                4120                4125            
Ala Arg Leu Leu Gln Asp Asp Ile Thr Phe Gly Leu Arg Lys Asn Ile
    4130                4135                4140                
Thr Asp Gln Gln Lys Phe Met Gly Ser Ser Leu Gly Thr Gly Leu Gly
4145                4150                4155                4160
Thr Leu Gly Asn Thr Ile Arg Ser Ala Leu Gln Asp Glu Ala Asp Lys
                4165                4170                4175    
Pro Tyr Ser Ser Gly Ser Arg Ser Arg Pro Ser Ser Arg Pro Ser Ser
            4180                4185                4190        
Val Tyr Gly Leu Asp Leu Ser Ile Lys Arg Asp Ser Ser Ser Ser Ser
        4195                4200                4205            
Leu Arg Leu Lys Ala Gln Glu Ala Glu Ala Leu Asp Val Ser Phe Ser
    4210                4215                4220                
His Ala Ser Ser Ser Ala Arg Thr Lys Pro Thr Ser Leu Pro Ile Ser
4225                4230                4235                4240
Gln Ser Arg Gly Arg Ile Pro Ile Val Ala Gln Asn Ser Glu Glu Glu
                4245                4250                4255    
Ser Pro Leu Ser Pro Val Gly Gln Pro Met Gly Met Ala Arg Ala Ala
            4260                4265                4270        
Ala Gly Pro Leu Pro Pro Ile Ser Ala Asp Thr Arg Asp Gln Phe Gly
        4275                4280                4285            
Ser Ser His Ser Leu Pro Glu Val Gln Gln His Met Arg Glu Glu Ser
    4290                4295                4300                
Arg Thr Arg Gly Tyr Asp Arg Asp Ile Ala Phe Ile Met Asp Asp Phe
4305                4310                4315                4320
Gln His Ala Met Ser Asp Ser Glu Ala Tyr His Leu Arg Arg Glu Glu
                4325                4330                4335    
Thr Asp Trp Phe Asp Lys Pro Arg Glu Ser Arg Leu Glu Asn Gly His
            4340                4345                4350        
Gly Leu Asp Arg Lys Leu Pro Glu Arg Leu Val His Ser Arg Pro Leu
        4355                4360                4365            
Ser Gln His Gln Glu Gln Ile Ile Gln Met Asn Gly Lys Thr Met His
    4370                4375                4380                
Tyr Ile Phe Pro His Ala Arg Ile Lys Ile Thr Arg Asp Ser Lys Asp
4385                4390                4395                4400
His Thr Val Ser Met Gln Val Leu Glu Trp Asn Gly Ile Pro Leu Thr
                4405                4410                4415    
Ser Lys Thr Tyr Glu Glu Val Gln Ser Ile Ile Ser Gln Gln Ser Gly
            4420                4425                4430        
Glu Ala Glu Ile Cys Val Arg Leu Asp Leu Asn Met Leu Ser Asp Ser
        4435                4440                4445            
Glu Asn Ser Gln His Leu Glu Leu His Glu Pro Pro Lys Ala Val Asp
    4450                4455                4460                
Lys Ala Lys Ser Pro Gly Val Asp Pro Lys Gln Leu Ala Ala Glu Leu
4465                4470                4475                4480
Gln Lys Val Ser Leu Gln Gln Ser Pro Leu Val Leu Ser Ser Val Val
                4485                4490                4495    
Glu Lys Gly Ser His Val His Ser Gly Pro Thr Ser Ala Gly Ser Ser
            4500                4505                4510        
Ser Val Pro Ser Pro Gly Gln Pro Gly Ser Pro Ser Val Ser Lys Lys
        4515                4520                4525            
Lys His Gly Ser Ser Lys Leu Gln Ile Asn Tyr Asp Leu Gly Asn Leu
    4530                4535                4540                
Ile Ile His Ile Leu Gln Ala Arg Asn Leu Val Pro Arg Asp Asn Asn
4545                4550                4555                4560
Gly Tyr Ser Asp Pro Phe Val Lys Val Tyr Leu Leu Pro Gly Arg Gly
                4565                4570                4575    
Ala Glu Tyr Lys Arg Arg Thr Lys His Val Gln Lys Ser Leu Asn Pro
            4580                4585                4590        
Glu Trp Asn Gln Thr Val Ile Tyr Lys Ser Ile Ser Met Glu Gln Leu
        4595                4600                4605            
Lys Lys Lys Thr Leu Glu Val Thr Val Trp Asp Tyr Asp Arg Phe Ser
    4610                4615                4620                
Ser Asn Asp Phe Leu Gly Glu Val Leu Ile Asp Leu Ser Ser Thr Ser
4625                4630                4635                4640
His Leu Asp Asn Thr Pro Arg Trp Tyr Pro Leu Lys Glu Gln Thr Glu
                4645                4650                4655    
Ser Ile Asp His Gly Lys Ser His Ser Ser Gln Ser Ser Gln Gln Ser
            4660                4665                4670        
Pro Lys Pro Ser Val Ile Lys Ser Arg Ser His Gly Ile Phe Pro Asp
        4675                4680                4685            
Pro Ser Lys Asp Met Gln Val Pro Thr Ile Glu Lys Ser His Ser Ser
    4690                4695                4700                
Pro Gly Ser Ser Lys Ser Ser Ser Glu Gly His Leu Arg Ser His Gly
4705                4710                4715                4720
Pro Ser Arg Ser Gln Ser Lys Thr Ser Val Thr Gln Thr His Leu Glu
                4725                4730                4735    
Asp Ala Gly Ala Ala Ile Ala Ala Ala Glu Ala Ala Val Gln Gln Leu
            4740                4745                4750        
Arg Ile Gln Pro Thr Ala His Lys Ser Gly Gln Ser Asn His Ala Arg
        4755                4760                4765            
Lys Gln His Arg His Ser Ile Ala Gly Val Leu Pro Ile Gln Arg Thr
    4770                4775                4780                
Gln Ser Asp Asn Leu Pro Pro Pro Ala Asn Gly Asn Gln Asp Gln Ser
4785                4790                4795                4800
Gln Leu Ala Leu Arg Lys Val Met Ser Asp Gly Pro Val Lys Pro Glu
                4805                4810                4815    
Gly Ala Lys Pro Pro Asn His Arg Pro Ala Glu Ser Ser Val Ser Thr
            4820                4825                4830        
Gly Ser Ser Gly Ser Ser Phe Gly Ser Gly Tyr Ser Val Asp Ser Glu
        4835                4840                4845            
Gly Ser Ser Ser Thr Ala Gly Glu Thr Asn Leu Phe Pro Ile Pro Arg
    4850                4855                4860                
Ile Gly Lys Met Gly Gln Asn Gly Gln Glu Pro Val Lys Gln Pro Gly
4865                4870                4875                4880
Val Gly Val Gly Leu Ala Asp Thr Glu Ala Arg Gly Gln Arg Glu Pro
                4885                4890                4895    
Lys Pro Gly Gln Ala Cys Phe Leu Gly Ala Arg Asn Met Lys Glu Ile
            4900                4905                4910        
Gln Pro Met Pro Glu Ile Tyr Pro Glu Thr Asp Lys Asp Gly Glu Lys
        4915                4920                4925            
Tyr Pro Gly Ser Leu Phe Leu Pro Phe Ser Asn Leu Cys Gln Cys Leu
    4930                4935                4940                
Ile Lys Thr Asn Trp Lys Pro Val Asp Gly Glu Ala Gln Ala Asp Leu
4945                4950                4955                4960
Glu Leu Leu Pro Asn Leu Gln Thr Arg Arg Ile Leu Pro Pro Ser Met
                4965                4970                4975    
Tyr Leu Leu Gln Lys Thr Lys Ala Leu Gln Thr Tyr Lys Arg Ser Asp
            4980                4985                4990        
Ile Arg Gly Ser Asn Gly Pro Thr Ile Asn Ala Thr Thr Cys Phe Glu
        4995                5000                5005            
Thr Thr Ser Val Met Gly Glu Ile Lys Ile Ala Leu Lys Lys Glu Met
    5010                5015                5020                
Lys Thr Asp Gly Glu Gln Leu Ile Val Glu Ile Leu Gln Cys Arg Asn
5025                5030                5035                5040
Ile Thr Tyr Lys Phe Lys Ser Pro Asp His Leu Pro Asp Leu Tyr Val
                5045                5050                5055    
Lys Ile Tyr Val Met Asn Ile Ser Thr Gln Lys Lys Val Ile Lys Lys
            5060                5065                5070        
Lys Thr Arg Val Cys Arg His Asp Arg Glu Pro Ser Phe Asn Glu Thr
        5075                5080                5085            
Phe Arg Phe Ser Leu Ser Pro Ala Gly His Ser Leu Gln Ile Leu Leu
    5090                5095                5100                
Phe Ser Asn Gly Gly Lys Phe Met Lys Lys Thr Leu Ile Gly Glu Ala
5105                5110                5115                5120
Cys Ile Trp Leu Asp Lys Val Asp Leu Arg Lys Arg Ile Val Asn Trp
                5125                5130                5135    
His Lys Leu Leu Val Ser Pro Thr Gln Thr His
            5140                5145        


<210> 7908
<211> 4830
<212> PRT
<213> Homo sapiens

<400> 7908
Ile Pro Ala Gly Met Glu Ala Asp Leu Ser Gln Leu Ser Glu Glu Glu
 1               5                  10                  15      
Arg Arg Gln Ile Ala Ala Val Met Ser Arg Ala Gln Gly Leu Pro Lys
            20                  25                  30          
Gly Ser Val Pro Pro Ala Ala Ala Glu Ser Pro Ser Met His Arg Lys
        35                  40                  45              
Gln Glu Leu Asp Ser Ser His Pro Pro Lys Gln Ser Gly Arg Pro Pro
    50                  55                  60                  
Asp Pro Gly Arg Pro Ala Gln Pro Gly Leu Ser Lys Ser Arg Thr Thr
65                  70                  75                  80  
Asp Thr Phe Arg Ser Glu Gln Lys Leu Pro Gly Arg Ser Pro Ser Thr
                85                  90                  95      
Ile Ser Leu Lys Glu Ser Lys Ser Arg Thr Asp Leu Lys Glu Glu His
            100                 105                 110         
Lys Ser Ser Met Met Pro Gly Phe Leu Ser Glu Val Asn Ala Leu Ser
        115                 120                 125             
Ala Val Ser Ser Val Val Asn Lys Phe Asn Pro Phe Asp Leu Ile Ser
    130                 135                 140                 
Asp Ser Glu Ala Ser Gln Glu Glu Thr Thr Lys Lys Gln Lys Val Val
145                 150                 155                 160 
Gln Lys Glu Gln Gly Lys Pro Glu Gly Ile Ile Lys Pro Pro Leu Gln
                165                 170                 175     
Gln Gln Pro Pro Lys Pro Ile Pro Lys Gln Gln Gly Pro Gly Arg Asp
            180                 185                 190         
Pro Leu Gln Gln Asp Gly Thr Pro Lys Ser Ile Ser Ser Gln Gln Pro
        195                 200                 205             
Glu Lys Ile Lys Ser Gln Pro Pro Gly Thr Gly Lys Pro Ile Gln Gly
    210                 215                 220                 
Pro Thr Gln Thr Pro Gln Thr Asp His Ala Lys Leu Pro Leu Gln Arg
225                 230                 235                 240 
Asp Ala Ser Arg Pro Gln Thr Lys Gln Ala Asp Ile Val Arg Gly Glu
                245                 250                 255     
Ser Val Lys Pro Ser Leu Pro Ser Pro Ser Lys Pro Pro Ile Gln Gln
            260                 265                 270         
Pro Thr Pro Gly Lys Pro Pro Ala Gln Gln Pro Gly His Glu Lys Ser
        275                 280                 285             
Gln Pro Gly Pro Ala Lys Pro Pro Ala Gln Pro Ser Gly Leu Thr Lys
    290                 295                 300                 
Pro Leu Ala Gln Gln Pro Gly Thr Val Lys Pro Pro Val Gln Pro Pro
305                 310                 315                 320 
Gly Thr Thr Lys Pro Pro Ala Gln Pro Leu Gly Pro Ala Lys Pro Pro
                325                 330                 335     
Ala Gln Gln Thr Gly Ser Glu Lys Pro Ser Ser Glu Gln Pro Gly Pro
            340                 345                 350         
Lys Ala Leu Ala Gln Pro Pro Gly Val Gly Lys Thr Pro Ala Gln Gln
        355                 360                 365             
Pro Gly Pro Ala Lys Pro Pro Thr Gln Gln Val Gly Thr Pro Lys Pro
    370                 375                 380                 
Leu Ala Gln Gln Pro Gly Leu Gln Ser Pro Ala Lys Ala Pro Gly Pro
385                 390                 395                 400 
Thr Lys Thr Pro Ala Gln Thr Lys Pro Pro Ser Gln Gln Pro Gly Ser
                405                 410                 415     
Thr Lys Pro Pro Pro Gln Gln Pro Gly Pro Ala Lys Pro Ser Pro Gln
            420                 425                 430         
Gln Pro Gly Ser Thr Lys Pro Pro Ser Gln Gln Pro Gly Ser Ala Lys
        435                 440                 445             
Pro Ser Ala Gln Gln Pro Ser Pro Ala Lys Pro Ser Ala Gln Gln Phe
    450                 455                 460                 
Thr Lys Pro Val Ser Gln Thr Gly Phe Gly Lys Pro Leu Gln Pro Pro
465                 470                 475                 480 
Thr Val Ser Pro Ser Ala Lys Gln Pro Pro Ser Gln Gly Leu Pro Lys
                485                 490                 495     
Thr Ile Cys Pro Leu Cys Asn Thr Thr Glu Leu Leu Leu His Val Pro
            500                 505                 510         
Glu Lys Ala Asn Phe Asn Thr Cys Thr Glu Cys Gln Thr Thr Val Cys
        515                 520                 525             
Ser Leu Cys Gly Phe Asn Pro Asn Pro His Leu Thr Glu Ala Lys Glu
    530                 535                 540                 
Trp Leu Cys Leu Asn Cys Gln Met Lys Arg Ala Leu Gly Gly Asp Leu
545                 550                 555                 560 
Ala Pro Val Pro Ser Ser Pro Gln Pro Lys Leu Lys Thr Ala Pro Val
                565                 570                 575     
Thr Thr Thr Ser Ala Val Ser Lys Ser Ser Pro Gln Pro Gln Gln Thr
            580                 585                 590         
Ser Pro Lys Lys Asp Ala Ala Pro Lys Gln Asp Leu Ser Lys Ala Pro
        595                 600                 605             
Glu Pro Lys Lys Pro Pro Pro Leu Val Lys Gln Pro Thr Leu His Gly
    610                 615                 620                 
Ser Pro Ser Ala Lys Ala Lys Gln Pro Pro Glu Ala Asp Ser Leu Ser
625                 630                 635                 640 
Lys Pro Ala Pro Pro Lys Glu Pro Ser Val Pro Ser Glu Gln Asp Lys
                645                 650                 655     
Ala Pro Val Ala Asp Asp Lys Pro Lys Gln Pro Lys Met Val Lys Pro
            660                 665                 670         
Thr Thr Asp Leu Val Ser Ser Ser Ser Ala Thr Thr Lys Pro Asp Ile
        675                 680                 685             
Pro Ser Ser Lys Val Gln Ser Gln Ala Glu Glu Lys Thr Thr Pro Pro
    690                 695                 700                 
Leu Lys Thr Asp Ser Ala Lys Pro Ser Gln Ser Phe Pro Pro Thr Gly
705                 710                 715                 720 
Glu Lys Val Thr Pro Phe Asp Ser Lys Ala Ile Pro Arg Pro Ala Ser
                725                 730                 735     
Asp Ser Lys Ile Ile Ser His Pro Gly Pro Ser Ser Glu Ser Lys Gly
            740                 745                 750         
Gln Lys Gln Val Asp Pro Val Gln Lys Lys Glu Glu Pro Lys Lys Ala
        755                 760                 765             
Gln Thr Lys Met Ser Pro Lys Pro Asp Ala Lys Pro Met Pro Lys Gly
    770                 775                 780                 
Ser Pro Thr Pro Pro Gly Pro Arg Pro Thr Ala Gly Gln Thr Val Pro
785                 790                 795                 800 
Thr Pro Gln Gln Ser Pro Lys Pro Gln Glu Gln Ser Arg Arg Phe Ser
                805                 810                 815     
Leu Asn Leu Gly Ser Ile Thr Asp Ala Pro Lys Ser Gln Pro Thr Thr
            820                 825                 830         
Pro Gln Glu Thr Val Thr Gly Lys Leu Phe Gly Phe Gly Ala Ser Ile
        835                 840                 845             
Phe Ser Gln Ala Ser Asn Leu Ile Ser Thr Ala Gly Gln Pro Gly Pro
    850                 855                 860                 
His Ser Gln Ser Gly Pro Gly Ala Pro Met Lys Gln Ala Pro Ala Pro
865                 870                 875                 880 
Ser Gln Pro Pro Thr Ser Gln Gly Pro Pro Lys Ser Thr Gly Gln Ala
                885                 890                 895     
Pro Pro Ala Pro Ala Lys Ser Ile Pro Val Lys Lys Glu Thr Lys Ala
            900                 905                 910         
Pro Ala Ala Glu Lys Leu Glu Pro Lys Ala Glu Gln Ala Pro Thr Val
        915                 920                 925             
Lys Arg Thr Glu Thr Glu Lys Lys Pro Pro Pro Ile Lys Asp Ser Lys
    930                 935                 940                 
Ser Leu Thr Ala Glu Pro Gln Lys Ala Val Leu Pro Thr Lys Leu Glu
945                 950                 955                 960 
Lys Ser Pro Lys Pro Glu Ser Thr Cys Pro Leu Cys Lys Thr Glu Leu
                965                 970                 975     
Asn Ile Gly Ser Lys Asp Pro Pro Asn Phe Asn Thr Cys Thr Glu Cys
            980                 985                 990         
Lys Asn Gln Val Cys Asn Leu Cys Gly Phe Asn Pro Thr Pro His Leu
        995                 1000                1005            
Thr Glu Asn Cys Gln Thr Gln Arg Ala Ile Ser Gly Gln Leu Gly Asp
    1010                1015                1020                
Ile Arg Lys Met Pro Pro Ala Pro Ser Gly Pro Lys Ala Ser Pro Met
1025                1030                1035                1040
Pro Val Pro Thr Glu Ser Ser Ser Gln Lys Thr Ala Val Pro Pro Gln
                1045                1050                1055    
Val Lys Leu Val Lys Lys Gln Glu Gln Glu Val Lys Thr Glu Ala Glu
            1060                1065                1070        
Lys Val Ile Leu Glu Lys Val Lys Glu Thr Leu Ser Met Glu Lys Ile
        1075                1080                1085            
Pro Pro Met Val Thr Thr Asp Gln Lys Gln Glu Glu Ser Lys Leu Glu
    1090                1095                1100                
Lys Asp Lys Ala Ser Ala Leu Gln Glu Lys Lys Pro Leu Pro Glu Glu
1105                1110                1115                1120
Lys Lys Leu Ile Pro Glu Glu Glu Lys Ile Arg Ser Glu Glu Lys Lys
                1125                1130                1135    
Pro Leu Leu Glu Glu Lys Lys Pro Thr Pro Glu Asp Lys Lys Leu Leu
            1140                1145                1150        
Pro Glu Ala Lys Thr Ser Ala Pro Glu Glu Gln Lys His Asp Leu Leu
        1155                1160                1165            
Lys Ser Gln Val Gln Ile Ala Glu Glu Lys Leu Glu Gly Arg Val Ala
    1170                1175                1180                
Pro Lys Thr Val Gln Glu Gly Lys Gln Pro Gln Thr Lys Met Glu Gly
1185                1190                1195                1200
Leu Pro Ser Gly Thr Pro Gln Ser Leu Pro Lys Glu Asp Asp Lys Thr
                1205                1210                1215    
Thr Lys Thr Ile Lys Glu Gln Pro Gln Pro Pro Cys Thr Ala Lys Pro
            1220                1225                1230        
Asp Gln Glu Lys Glu Asp Asp Lys Ser Asp Thr Ser Ser Ser Gln Gln
        1235                1240                1245            
Pro Lys Ser Pro Gln Gly Leu Ser Asp Thr Gly Tyr Ser Ser Asp Gly
    1250                1255                1260                
Ile Ser Ser Ser Leu Gly Glu Ile Pro Ser Leu Ile Pro Thr Asp Glu
1265                1270                1275                1280
Lys Asp Ile Leu Lys Gly Leu Lys Lys Asp Ser Phe Ser Gln Glu Ser
                1285                1290                1295    
Ser Pro Ser Ser Pro Ser Asp Leu Ala Lys Leu Glu Ser Thr Val Leu
            1300                1305                1310        
Ser Ile Leu Glu Ala Gln Ala Ser Thr Leu Ala Asp Glu Lys Ser Glu
        1315                1320                1325            
Lys Lys Thr Gln Pro His Glu Val Ser Pro Glu Gln Pro Lys Asp Gln
    1330                1335                1340                
Glu Lys Thr Gln Ser Leu Ser Glu Thr Leu Glu Ile Thr Ile Ser Glu
1345                1350                1355                1360
Glu Glu Ile Lys Glu Ser Gln Glu Glu Arg Lys Asp Thr Phe Lys Lys
                1365                1370                1375    
Asp Ser Gln Gln Asp Ile Pro Ser Ser Lys Asp His Lys Glu Lys Ser
            1380                1385                1390        
Glu Phe Val Asp Asp Ile Thr Thr Arg Arg Glu Pro Tyr Asp Ser Val
        1395                1400                1405            
Glu Glu Ser Ser Glu Ser Glu Asn Ser Pro Val Pro Gln Arg Lys Arg
    1410                1415                1420                
Arg Thr Ser Val Gly Ser Ser Ser Ser Asp Glu Tyr Lys Gln Glu Asp
1425                1430                1435                1440
Ser Gln Gly Ser Gly Glu Glu Glu Asp Phe Ile Arg Lys Gln Ile Ile
                1445                1450                1455    
Glu Met Ser Ala Asp Glu Asp Ala Ser Gly Ser Glu Asp Asp Glu Phe
            1460                1465                1470        
Ile Arg Asn Gln Leu Lys Glu Ile Ser Ser Ser Thr Glu Ser Gln Lys
        1475                1480                1485            
Lys Glu Glu Thr Lys Gly Lys Gly Lys Ile Thr Ala Gly Lys His Arg
    1490                1495                1500                
Arg Leu Thr Arg Lys Ser Ser Thr Ser Ile Asp Glu Asp Ala Gly Arg
1505                1510                1515                1520
Arg His Ser Trp His Asp Glu Asp Asp Glu Ala Phe Asp Glu Ser Pro
                1525                1530                1535    
Glu Leu Lys Tyr Arg Glu Thr Lys Ser Gln Glu Ser Glu Glu Leu Val
            1540                1545                1550        
Val Thr Gly Gly Gly Gly Leu Arg Arg Phe Lys Thr Ile Glu Leu Asn
        1555                1560                1565            
Ser Thr Ile Ala Asp Lys Tyr Ser Ala Glu Ser Ser Gln Lys Lys Thr
    1570                1575                1580                
Ser Leu Tyr Phe Asp Glu Glu Pro Glu Leu Glu Met Glu Ser Leu Thr
1585                1590                1595                1600
Asp Ser Pro Glu Asp Arg Ser Arg Gly Glu Gly Ser Ser Ser Leu His
                1605                1610                1615    
Ala Ser Ser Phe Thr Pro Gly Thr Ser Pro Thr Ser Val Ser Ser Leu
            1620                1625                1630        
Asp Glu Asp Ser Asp Ser Ser Pro Ser His Lys Lys Gly Glu Ser Lys
        1635                1640                1645            
Gln Gln Arg Lys Ala Arg His Arg Pro His Gly Pro Leu Leu Pro Thr
    1650                1655                1660                
Ile Glu Asp Ser Ser Glu Glu Glu Glu Leu Arg Glu Glu Glu Glu Leu
1665                1670                1675                1680
Leu Lys Glu Gln Glu Lys Gln Arg Glu Ile Glu Gln Gln Gln Arg Lys
                1685                1690                1695    
Ser Ser Ser Lys Lys Ser Lys Lys Asp Lys Asp Glu Leu Arg Ala Gln
            1700                1705                1710        
Arg Arg Arg Glu Arg Pro Lys Thr Pro Pro Ser Asn Leu Ser Pro Ile
        1715                1720                1725            
Glu Asp Ala Ser Pro Thr Glu Glu Leu Arg Gln Ala Ala Glu Met Glu
    1730                1735                1740                
Glu Leu His Arg Ser Ser Cys Ser Glu Tyr Ser Pro Ser Ile Glu Ser
1745                1750                1755                1760
Asp Pro Glu Gly Phe Glu Ile Ser Pro Glu Lys Ile Ile Glu Val Gln
                1765                1770                1775    
Lys Val Tyr Lys Leu Pro Thr Ala Val Ser Leu Tyr Ser Pro Thr Asp
            1780                1785                1790        
Glu Gln Ser Ile Met Gln Lys Glu Gly Ser Gln Lys Ala Leu Lys Ser
        1795                1800                1805            
Ala Glu Glu Met Tyr Glu Glu Met Met His Lys Thr His Lys Tyr Lys
    1810                1815                1820                
Ala Phe Pro Ala Ala Asn Glu Arg Asp Glu Val Phe Glu Lys Glu Pro
1825                1830                1835                1840
Leu Tyr Gly Gly Met Leu Ile Glu Asp Tyr Ile Tyr Glu Ser Leu Val
                1845                1850                1855    
Glu Asp Thr Tyr Asn Gly Ser Val Asp Gly Ser Leu Leu Thr Arg Gln
            1860                1865                1870        
Glu Glu Glu Asn Gly Phe Met Gln Gln Lys Gly Arg Glu Gln Lys Ile
        1875                1880                1885            
Arg Leu Ser Glu Gln Ile Tyr Glu Asp Pro Met Gln Lys Ile Thr Asp
    1890                1895                1900                
Leu Gln Lys Glu Phe Tyr Glu Leu Glu Ser Leu His Ser Val Val Pro
1905                1910                1915                1920
Gln Glu Asp Ile Val Ser Ser Ser Phe Ile Ile Pro Glu Ser His Glu
                1925                1930                1935    
Ile Val Asp Leu Gly Thr Met Val Thr Ser Thr Glu Glu Glu Arg Lys
            1940                1945                1950        
Leu Leu Asp Ala Asp Ala Ala Tyr Glu Glu Leu Met Lys Arg Gln Gln
        1955                1960                1965            
Met Gln Leu Thr Pro Gly Ser Ser Pro Thr Gln Ala Pro Ile Gly Glu
    1970                1975                1980                
Asp Met Thr Glu Ser Thr Met Asp Phe Asp Arg Met Pro Asp Ala Ser
1985                1990                1995                2000
Leu Thr Ser Ser Val Leu Ser Gly Ala Ser Leu Thr Asp Ser Thr Ser
                2005                2010                2015    
Ser Ala Thr Leu Ser Ile Pro Asp Val Lys Ile Thr Gln His Phe Ser
            2020                2025                2030        
Thr Glu Glu Ile Glu Asp Glu Tyr Val Thr Asp Tyr Thr Arg Glu Ile
        2035                2040                2045            
Gln Glu Ile Ile Ala His Glu Ser Leu Ile Leu Thr Tyr Ser Glu Pro
    2050                2055                2060                
Ser Glu Ser Ala Thr Ser Val Pro Pro Ser Asp Thr Pro Ser Leu Thr
2065                2070                2075                2080
Ser Ser Val Ser Ser Val Cys Thr Thr Asp Ser Ser Ser Pro Ile Thr
                2085                2090                2095    
Thr Leu Asp Ser Ile Thr Thr Val Tyr Thr Glu Pro Val Asp Met Ile
            2100                2105                2110        
Thr Lys Phe Glu Asp Ser Glu Glu Ile Ser Ser Ser Thr Tyr Phe Pro
        2115                2120                2125            
Gly Ser Ile Ile Asp Tyr Pro Glu Glu Ile Ser Val Ser Leu Asp Arg
    2130                2135                2140                
Thr Ala Pro Pro Asp Gly Arg Ala Ser Ala Asp His Ile Val Ile Ser
2145                2150                2155                2160
Leu Ser Asp Met Ala Ser Ser Ile Ile Glu Ser Val Val Pro Lys Pro
                2165                2170                2175    
Glu Gly Pro Val Ala Asp Thr Val Ser Thr Asp Leu Leu Ile Ser Glu
            2180                2185                2190        
Lys Asp Pro Val Lys Lys Ala Lys Lys Glu Thr Gly Asn Gly Ile Ile
        2195                2200                2205            
Leu Glu Val Leu Glu Ala Tyr Arg Asp Lys Lys Glu Leu Glu Ala Glu
    2210                2215                2220                
Arg Thr Lys Ser Ser Leu Ser Glu Thr Val Phe Asp His Pro Pro Ser
2225                2230                2235                2240
Ser Val Ile Ala Leu Pro Met Lys Glu Gln Leu Ser Thr Thr Tyr Phe
                2245                2250                2255    
Thr Ser Gly Glu Thr Phe Gly Gln Glu Lys Pro Ala Ser Gln Leu Pro
            2260                2265                2270        
Ser Gly Ser Pro Ser Val Ser Ser Leu Pro Ala Lys Pro Arg Pro Phe
        2275                2280                2285            
Phe Arg Ser Ser Ser Leu Asp Ile Ser Ala Gln Pro Pro Pro Pro Pro
    2290                2295                2300                
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
2305                2310                2315                2320
Pro Leu Pro Pro Pro Thr Ser Pro Lys Pro Thr Ile Leu Pro Lys Lys
                2325                2330                2335    
Lys Leu Thr Val Ala Ser Pro Val Thr Thr Ala Thr Pro Leu Phe Asp
            2340                2345                2350        
Ala Val Thr Thr Leu Glu Thr Thr Ala Val Leu Arg Ser Asn Gly Leu
        2355                2360                2365            
Pro Val Thr Arg Ile Cys Thr Thr Ala Pro Pro Pro Val Pro Pro Lys
    2370                2375                2380                
Pro Ser Ser Ile Pro Ser Gly Leu Val Phe Thr His Arg Pro Glu Pro
2385                2390                2395                2400
Ser Lys Pro Pro Ile Ala Pro Lys Pro Val Ile Pro Gln Leu Pro Thr
                2405                2410                2415    
Thr Thr Gln Lys Pro Thr Asp Ile His Pro Lys Pro Thr Gly Leu Ser
            2420                2425                2430        
Leu Thr Ser Ser Met Thr Leu Asn Leu Val Thr Ser Ala Asp Tyr Lys
        2435                2440                2445            
Leu Pro Ser Pro Thr Ser Pro Leu Ser Pro His Ser Asn Lys Ser Ser
    2450                2455                2460                
Pro Arg Phe Ser Lys Ser Leu Thr Glu Thr Tyr Val Val Ile Thr Leu
2465                2470                2475                2480
Pro Ser Glu Pro Gly Thr Pro Thr Asp Ser Ser Ala Ser Gln Ala Ile
                2485                2490                2495    
Thr Ser Trp Pro Leu Gly Ser Pro Ser Lys Asp Leu Val Ser Val Glu
            2500                2505                2510        
Pro Val Phe Ser Val Val Pro Pro Val Thr Ala Val Glu Ile Pro Ile
        2515                2520                2525            
Ser Ser Glu Gln Thr Phe Tyr Ile Ser Gly Ala Leu Gln Thr Phe Ser
    2530                2535                2540                
Ala Thr Pro Val Thr Ala Pro Ser Ser Phe Gln Ala Ala Pro Thr Ser
2545                2550                2555                2560
Val Thr Gln Phe Leu Thr Thr Glu Val Ser Lys Thr Glu Val Ser Ala
                2565                2570                2575    
Thr Arg Ser Thr Ala Pro Ser Val Gly Leu Ser Ser Ile Ser Ile Thr
            2580                2585                2590        
Ile Pro Pro Glu Pro Leu Ala Leu Asp Asn Ile His Leu Glu Lys Pro
        2595                2600                2605            
Gln Tyr Lys Glu Asp Gly Lys Leu Gln Leu Val Gly Asp Val Ile Asp
    2610                2615                2620                
Leu Arg Thr Val Pro Lys Val Glu Val Lys Thr Thr Asp Lys Cys Ile
2625                2630                2635                2640
Asp Leu Ser Ala Ser Thr Met Asp Val Lys Arg Gln Ile Thr Ala Asn
                2645                2650                2655    
Glu Val Tyr Gly Lys Gln Ile Ser Ala Val Gln Pro Ser Ile Ile Asn
            2660                2665                2670        
Leu Ser Val Thr Ser Ser Ile Val Thr Pro Val Ser Leu Ala Thr Glu
        2675                2680                2685            
Thr Val Thr Phe Val Thr Cys Thr Ala Ser Ala Ser Tyr Thr Thr Gly
    2690                2695                2700                
Thr Glu Ser Leu Val Gly Ala Glu His Ala Met Thr Thr Pro Leu Gln
2705                2710                2715                2720
Leu Thr Thr Ser Lys His Ala Glu Pro Pro Tyr Arg Ile Pro Ser Asp
                2725                2730                2735    
Gln Val Phe Pro Ile Ala Arg Glu Glu Ala Pro Ile Asn Leu Ser Leu
            2740                2745                2750        
Gly Thr Pro Ala His Ala Val Thr Leu Ala Ile Thr Lys Pro Val Thr
        2755                2760                2765            
Val Pro Pro Val Gly Val Thr Asn Gly Trp Thr Asp Ser Thr Val Ser
    2770                2775                2780                
Gln Gly Ile Thr Asp Gly Glu Val Val Asp Leu Ser Thr Thr Lys Ser
2785                2790                2795                2800
His Arg Thr Val Val Thr Met Asp Glu Ser Thr Ser Ser Val Met Thr
                2805                2810                2815    
Lys Ile Ile Glu Asp Glu Lys Pro Val Asp Leu Thr Ala Gly Arg Arg
            2820                2825                2830        
Ala Val Cys Cys Asp Val Val Tyr Lys Leu Pro Phe Gly Arg Ser Cys
        2835                2840                2845            
Thr Ala Gln Gln Pro Ala Thr Thr Leu Pro Glu Asp Arg Phe Gly Tyr
    2850                2855                2860                
Arg Asp Asp His Tyr Gln Tyr Asp Arg Ser Gly Pro Tyr Gly Tyr Arg
2865                2870                2875                2880
Gly Ile Gly Gly Met Lys Pro Ser Met Ser Asp Thr Asn Leu Ala Glu
                2885                2890                2895    
Ala Gly His Phe Phe Tyr Lys Ser Lys Asn Ala Phe Asp Tyr Ser Glu
            2900                2905                2910        
Gly Thr Asp Thr Ala Val Asp Leu Thr Ser Gly Arg Val Thr Thr Gly
        2915                2920                2925            
Glu Val Met Asp Tyr Ser Ser Lys Thr Thr Gly Pro Tyr Pro Glu Thr
    2930                2935                2940                
Arg Gln Val Ile Ser Gly Ala Gly Ile Ser Thr Pro Gln Tyr Ser Thr
2945                2950                2955                2960
Ala Arg Met Thr Pro Pro Pro Gly Pro Gln Tyr Cys Val Gly Ser Val
                2965                2970                2975    
Leu Arg Ser Ser Asn Gly Val Val Tyr Ser Ser Val Ala Thr Pro Thr
            2980                2985                2990        
Pro Ser Thr Phe Ala Ile Thr Thr Gln Pro Gly Ser Ile Phe Ser Thr
        2995                3000                3005            
Thr Val Arg Asp Leu Ser Gly Ile His Thr Ala Asp Ala Val Thr Ser
    3010                3015                3020                
Leu Pro Ala Met His His Ser Gln Pro Met Pro Arg Ser Tyr Phe Ile
3025                3030                3035                3040
Thr Thr Gly Ala Ser Glu Thr Asp Ile Ala Val Thr Gly Ile Asp Ile
                3045                3050                3055    
Ser Ala Ser Leu Gln Thr Ile Thr Met Glu Ser Leu Thr Ala Glu Thr
            3060                3065                3070        
Ile Asp Ser Val Pro Thr Leu Thr Thr Ala Ser Glu Val Phe Pro Glu
        3075                3080                3085            
Val Val Gly Asp Glu Ser Ala Leu Leu Ile Val Pro Glu Glu Asp Lys
    3090                3095                3100                
Gln Gln Gln Gln Leu Asp Leu Glu Arg Glu Leu Leu Glu Leu Glu Lys
3105                3110                3115                3120
Ile Lys Gln Gln Arg Phe Ala Glu Glu Leu Glu Trp Glu Arg Gln Glu
                3125                3130                3135    
Ile Gln Arg Phe Arg Glu Gln Glu Lys Ile Met Val Gln Lys Lys Leu
            3140                3145                3150        
Glu Glu Leu Gln Ser Met Lys Gln His Leu Leu Phe Gln Gln Glu Glu
        3155                3160                3165            
Glu Arg Gln Ala Gln Phe Met Met Arg Gln Glu Thr Leu Ala Gln Gln
    3170                3175                3180                
Gln Leu Gln Leu Glu Gln Ile Gln Gln Leu Gln Gln Gln Leu His Gln
3185                3190                3195                3200
Gln Leu Glu Glu Gln Lys Ile Arg Gln Ile Tyr Gln Tyr Asn Tyr Asp
                3205                3210                3215    
Pro Ser Gly Thr Ala Ser Pro Gln Thr Thr Thr Glu Gln Ala Ile Leu
            3220                3225                3230        
Glu Gly Gln Tyr Ala Ala Leu Glu Gly Ser Gln Phe Trp Ala Thr Glu
        3235                3240                3245            
Asp Ala Thr Thr Thr Ala Ser Ala Val Val Ala Ile Glu Ile Pro Gln
    3250                3255                3260                
Ser Gln Gly Trp Tyr Thr Val Gln Ser Asp Gly Val Thr Gln Tyr Ile
3265                3270                3275                3280
Ala Pro Pro Gly Ile Leu Ser Thr Val Ser Glu Ile Pro Leu Thr Asp
                3285                3290                3295    
Val Val Val Lys Glu Glu Lys Gln Pro Lys Lys Arg Ser Ser Gly Ala
            3300                3305                3310        
Lys Val Arg Gly Gln Tyr Asp Asp Met Gly Glu Asn Met Thr Asp Asp
        3315                3320                3325            
Pro Arg Ser Phe Lys Lys Ile Val Asp Ser Gly Val Gln Thr Asp Asp
    3330                3335                3340                
Glu Asp Ala Thr Asp Arg Ser Tyr Val Ser Arg Arg Arg Arg Thr Lys
3345                3350                3355                3360
Lys Ser Val Asp Thr Ser Val Gln Thr Asp Asp Glu Asp Gln Asp Glu
                3365                3370                3375    
Trp Asp Met Pro Thr Arg Ser Arg Arg Lys Ala Arg Val Gly Lys Tyr
            3380                3385                3390        
Gly Asp Ser Met Thr Glu Ala Asp Lys Thr Lys Pro Leu Ser Lys Val
        3395                3400                3405            
Ser Ser Ile Ala Val Gln Thr Val Ala Glu Ile Ser Val Gln Thr Glu
    3410                3415                3420                
Pro Val Gly Thr Ile Arg Thr Pro Ser Ile Arg Ala Arg Val Asp Ala
3425                3430                3435                3440
Lys Val Glu Ile Ile Lys His Ile Ser Ala Pro Glu Lys Thr Tyr Lys
                3445                3450                3455    
Gly Gly Ser Leu Gly Cys Gln Thr Glu Ala Asp Ser Asp Thr Gln Ser
            3460                3465                3470        
Pro Gln Tyr Leu Ser Ala Thr Ser Pro Pro Lys Asp Lys Lys Arg Pro
        3475                3480                3485            
Thr Pro Leu Glu Ile Gly Tyr Ser Ser His Leu Arg Ala Asp Ser Thr
    3490                3495                3500                
Val Gln Leu Ala Pro Ser Pro Pro Lys Ser Pro Lys Val Leu Tyr Ser
3505                3510                3515                3520
Pro Ile Ser Pro Leu Ser Pro Gly Lys Ala Leu Glu Ser Ala Phe Val
                3525                3530                3535    
Pro Tyr Glu Lys Pro Leu Pro Asp Asp Ile Ser Pro Gln Lys Val Leu
            3540                3545                3550        
His Pro Asp Met Ala Lys Val Pro Pro Ala Ser Pro Lys Thr Ala Lys
        3555                3560                3565            
Met Met Gln Arg Ser Met Ser Asp Pro Lys Pro Leu Ser Pro Thr Ala
    3570                3575                3580                
Asp Glu Ser Ser Arg Ala Pro Phe Gln Tyr Thr Glu Gly Tyr Thr Thr
3585                3590                3595                3600
Lys Gly Ser Gln Thr Met Thr Ser Ser Gly Ala Gln Lys Lys Val Lys
                3605                3610                3615    
Arg Thr Leu Pro Asn Pro Pro Pro Glu Glu Ile Ser Thr Gly Thr Gln
            3620                3625                3630        
Ser Thr Phe Ser Thr Met Gly Thr Val Ser Arg Arg Arg Ile Cys Arg
        3635                3640                3645            
Thr Asn Thr Met Ala Arg Ala Lys Ile Leu Gln Asp Ile Asp Arg Glu
    3650                3655                3660                
Leu Asp Leu Val Glu Arg Glu Ser Ala Lys Leu Arg Lys Lys Gln Ala
3665                3670                3675                3680
Glu Leu Asp Glu Glu Glu Lys Glu Ile Asp Ala Lys Leu Arg Tyr Leu
                3685                3690                3695    
Glu Met Gly Ile Asn Arg Arg Lys Glu Ala Leu Leu Lys Glu Arg Glu
            3700                3705                3710        
Lys Arg Glu Arg Ala Tyr Leu Gln Gly Val Ala Glu Asp Arg Asp Tyr
        3715                3720                3725            
Met Ser Asp Ser Glu Val Ser Ser Thr Arg Pro Thr Arg Ile Glu Ser
    3730                3735                3740                
Gln His Gly Ile Glu Arg Pro Arg Thr Ala Pro Gln Thr Glu Phe Ser
3745                3750                3755                3760
Gln Phe Ile Pro Pro Gln Thr Gln Thr Glu Ser Gln Leu Val Pro Pro
                3765                3770                3775    
Thr Ser Pro Tyr Thr Gln Tyr Gln Tyr Ser Ser Pro Ala Leu Pro Thr
            3780                3785                3790        
Gln Ala Pro Thr Ser Tyr Thr Gln Gln Ser His Phe Glu Gln Gln Thr
        3795                3800                3805            
Leu Tyr His Gln Gln Val Ser Pro Tyr Gln Thr Gln Pro Thr Phe Gln
    3810                3815                3820                
Ala Val Ala Thr Met Ser Phe Thr Pro Gln Val Gln Pro Thr Pro Thr
3825                3830                3835                3840
Pro Gln Pro Ser Tyr Gln Leu Pro Ser Gln Met Met Val Ile Gln Gln
                3845                3850                3855    
Lys Pro Arg Gln Thr Thr Leu Tyr Leu Glu Pro Lys Ile Thr Ser Asn
            3860                3865                3870        
Tyr Glu Val Ile Arg Asn Gln Pro Leu Met Ile Ala Pro Val Ser Thr
        3875                3880                3885            
Asp Asn Thr Phe Ala Val Ser His Leu Gly Ser Lys Tyr Asn Ser Leu
    3890                3895                3900                
Asp Leu Arg Ile Gly Leu Glu Glu Arg Ser Ser Met Ala Ser Ser Pro
3905                3910                3915                3920
Ile Ser Ser Ile Ser Ala Asp Ser Phe Tyr Ala Asp Ile Asp His His
                3925                3930                3935    
Thr Pro Arg Asn Tyr Val Leu Ile Asp Asp Ile Gly Glu Ile Thr Lys
            3940                3945                3950        
Gly Thr Ala Ala Leu Ser Thr Ala Phe Ser Leu His Glu Lys Asp Leu
        3955                3960                3965            
Ser Lys Thr Asp Arg Leu Leu Arg Thr Thr Glu Thr Arg Arg Ser Gln
    3970                3975                3980                
Glu Val Thr Asp Phe Leu Ala Pro Leu Gln Ser Ser Ser Arg Leu His
3985                3990                3995                4000
Ser Tyr Val Lys Ala Glu Glu Asp Pro Met Glu Asp Pro Tyr Glu Leu
                4005                4010                4015    
Lys Leu Leu Lys His Gln Ile Lys Gln Glu Phe Arg Arg Gly Thr Glu
            4020                4025                4030        
Ser Leu Asp His Leu Ala Gly Leu Ser His Tyr Tyr His Ala Asp Thr
        4035                4040                4045            
Ser Tyr Arg His Phe Pro Lys Ser Glu Lys Tyr Ser Ile Ser Arg Leu
    4050                4055                4060                
Thr Leu Glu Lys Gln Ala Ala Lys Gln Leu Pro Ala Ala Ile Leu Tyr
4065                4070                4075                4080
Gln Lys Gln Ser Lys His Lys Lys Ser Leu Ile Asp Pro Lys Met Ser
                4085                4090                4095    
Lys Phe Ser Pro Ile Gln Glu Ser Arg Asp Leu Glu Pro Asp Tyr Ser
            4100                4105                4110        
Ser Tyr Met Thr Ser Ser Thr Ser Ser Ile Gly Gly Ile Ser Ser Arg
        4115                4120                4125            
Ala Arg Leu Leu Gln Asp Asp Ile Thr Phe Gly Leu Arg Lys Asn Ile
    4130                4135                4140                
Thr Asp Gln Gln Lys Phe Met Gly Ser Ser Leu Gly Thr Gly Leu Gly
4145                4150                4155                4160
Thr Leu Gly Asn Thr Ile Arg Ser Ala Leu Gln Asp Glu Ala Asp Lys
                4165                4170                4175    
Pro Tyr Ser Ser Gly Ser Arg Ser Arg Pro Ser Ser Arg Pro Ser Ser
            4180                4185                4190        
Val Tyr Gly Leu Asp Leu Ser Ile Lys Arg Asp Ser Ser Ser Ser Ser
        4195                4200                4205            
Leu Arg Leu Lys Ala Gln Glu Ala Glu Ala Leu Asp Val Ser Phe Ser
    4210                4215                4220                
His Ala Ser Ser Ser Ala Arg Thr Lys Pro Thr Ser Leu Pro Ile Ser
4225                4230                4235                4240
Gln Ser Arg Gly Arg Ile Pro Ile Val Ala Gln Asn Ser Glu Glu Glu
                4245                4250                4255    
Ser Pro Leu Ser Pro Val Gly Gln Pro Met Gly Met Ala Arg Ala Ala
            4260                4265                4270        
Ala Gly Pro Leu Pro Pro Ile Ser Ala Asp Thr Arg Asp Gln Phe Gly
        4275                4280                4285            
Ser Ser His Ser Leu Pro Glu Val Gln Gln His Met Arg Glu Glu Ser
    4290                4295                4300                
Arg Thr Arg Gly Tyr Asp Arg Asp Ile Ala Phe Ile Met Asp Asp Phe
4305                4310                4315                4320
Gln His Ala Met Ser Asp Ser Glu Ala Tyr His Leu Arg Arg Glu Glu
                4325                4330                4335    
Thr Asp Trp Phe Asp Lys Pro Arg Glu Ser Arg Leu Glu Asn Gly His
            4340                4345                4350        
Gly Leu Asp Arg Lys Leu Pro Glu Arg Leu Val His Ser Arg Pro Leu
        4355                4360                4365            
Ser Gln His Gln Glu Gln Ile Ile Gln Met Asn Gly Lys Thr Met His
    4370                4375                4380                
Tyr Ile Phe Pro His Ala Arg Ile Lys Ile Thr Arg Asp Ser Lys Asp
4385                4390                4395                4400
His Thr Val Ser Gly Asn Gly Leu Gly Ile Arg Ile Val Gly Gly Lys
                4405                4410                4415    
Glu Ile Pro Gly His Ser Gly Glu Ile Gly Ala Tyr Ile Ala Lys Ile
            4420                4425                4430        
Leu Pro Gly Gly Ser Ala Glu Gln Thr Gly Lys Leu Met Glu Gly Met
        4435                4440                4445            
Gln Val Leu Glu Trp Asn Gly Ile Pro Leu Thr Ser Lys Thr Tyr Glu
    4450                4455                4460                
Glu Val Gln Ser Ile Ile Ser Gln Gln Ser Gly Glu Ala Glu Ile Cys
4465                4470                4475                4480
Val Arg Leu Asp Leu Asn Met Leu Ser Asp Ser Glu Asn Ser Gln His
                4485                4490                4495    
Leu Glu Leu His Glu Pro Pro Lys Ala Val Asp Lys Ala Lys Ser Pro
            4500                4505                4510        
Gly Val Asp Pro Lys Gln Leu Ala Ala Glu Leu Gln Lys Val Ser Leu
        4515                4520                4525            
Gln Gln Ser Pro Leu Val Leu Ser Ser Val Val Glu Lys Gly Ser His
    4530                4535                4540                
Val His Ser Gly Pro Thr Ser Ala Gly Ser Ser Ser Val Pro Ser Pro
4545                4550                4555                4560
Gly Gln Pro Gly Ser Pro Ser Val Ser Lys Lys Lys His Gly Ser Ser
                4565                4570                4575    
Lys Pro Thr Asp Gly Thr Lys Val Val Ser His Pro Ile Thr Gly Glu
            4580                4585                4590        
Ile Gln Leu Gln Ile Asn Tyr Asp Leu Gly Asn Leu Ile Ile His Ile
        4595                4600                4605            
Leu Gln Ala Arg Asn Leu Val Pro Arg Asp Asn Asn Gly Tyr Ser Asp
    4610                4615                4620                
Pro Phe Val Lys Val Tyr Leu Leu Pro Gly Arg Gly Gln Val Met Val
4625                4630                4635                4640
Val Gln Asn Ala Ser Ala Glu Tyr Lys Arg Arg Thr Lys His Val Gln
                4645                4650                4655    
Lys Ser Leu Asn Pro Glu Trp Asn Gln Thr Val Ile Tyr Lys Ser Ile
            4660                4665                4670        
Ser Met Glu Gln Leu Lys Lys Lys Thr Leu Glu Val Thr Val Trp Asp
        4675                4680                4685            
Tyr Asp Arg Phe Ser Ser Asn Asp Phe Leu Gly Glu Val Leu Ile Asp
    4690                4695                4700                
Leu Ser Ser Thr Ser His Leu Asp Asn Thr Pro Arg Trp Tyr Pro Leu
4705                4710                4715                4720
Lys Glu Gln Thr Glu Ser Ile Asp His Gly Lys Ser His Ser Ser Gln
                4725                4730                4735    
Ser Ser Gln Gln Ser Pro Lys Pro Ser Val Ile Lys Ser Arg Ser His
            4740                4745                4750        
Gly Ile Phe Pro Asp Pro Ser Lys Asp Met Gln Val Pro Thr Ile Glu
        4755                4760                4765            
Lys Ser His Ser Ser Pro Gly Ser Ser Lys Ser Ser Ser Glu Gly His
    4770                4775                4780                
Leu Arg Ser His Gly Pro Ser Arg Ser Gln Ser Lys Thr Ser Val Thr
4785                4790                4795                4800
Gln Thr His Leu Glu Asp Ala Gly Ala Ala Ile Ala Ala Ala Glu Ala
                4805                4810                4815    
Ala Val Gln Gln Leu Arg Ile Gln Pro Ser Lys Arg Arg Lys
            4820                4825                4830


<210> 7909
<211> 1163
<212> PRT
<213> Homo sapiens

<400> 7909
Met Asn Arg Glu Asp Arg Asn Val Leu Arg Met Lys Glu Arg Glu Arg
 1               5                  10                  15      
Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp Ala Phe Pro Pro Ser Ser
            20                  25                  30          
Pro Leu Phe Ala Glu Pro Tyr Lys Val Thr Ser Lys Glu Asp Lys Leu
        35                  40                  45              
Ser Ser Arg Ile Gln Ser Met Leu Gly Asn Tyr Asp Glu Met Lys Asp
    50                  55                  60                  
Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu Val Ala Ile Pro Lys Pro
65                  70                  75                  80  
Thr Val Pro Pro Ser Ala Asp Glu Lys Ser Asn Pro Asn Phe Phe Glu
                85                  90                  95      
Gln Arg His Gly Gly Ser His Gln Ser Ser Lys Trp Thr Pro Val Gly
            100                 105                 110         
Pro Ala Pro Ser Thr Ser Gln Ser Gln Lys Arg Ser Ser Gly Leu Gln
        115                 120                 125             
Ser Gly His Ser Ser Gln Arg Thr Ser Ala Gly Ser Ser Ser Gly Thr
    130                 135                 140                 
Asn Ser Ser Gly Gln Arg His Asp Arg Glu Ser Tyr Asn Asn Ser Gly
145                 150                 155                 160 
Ser Ser Ser Arg Lys Lys Gly Gln His Gly Ser Glu His Ser Lys Ser
                165                 170                 175     
Arg Ser Ser Ser Pro Gly Lys Pro Gln Ala Val Ser Ser Leu Asn Ser
            180                 185                 190         
Ser His Ser Arg Ser His Gly Asn Asp His His Ser Lys Glu His Gln
        195                 200                 205             
Arg Ser Lys Ser Pro Arg Asp Pro Asp Ala Asn Trp Asp Ser Pro Ser
    210                 215                 220                 
Arg Val Pro Phe Ser Ser Gly Gln His Ser Thr Gln Ser Phe Pro Pro
225                 230                 235                 240 
Ser Leu Met Ser Lys Ser Asn Ser Met Leu Gln Lys Pro Thr Ala Tyr
                245                 250                 255     
Val Arg Pro Met Asp Gly Gln Glu Ser Met Glu Pro Lys Leu Ser Ser
            260                 265                 270         
Glu His Tyr Ser Ser Gln Ser His Gly Asn Ser Met Thr Glu Leu Lys
        275                 280                 285             
Pro Ser Ser Lys Ala His Leu Thr Lys Leu Lys Ile Pro Ser Gln Pro
    290                 295                 300                 
Leu Asp Ala Ser Ala Ser Gly Asp Val Ser Cys Val Asp Glu Ile Leu
305                 310                 315                 320 
Lys Glu Met Thr His Ser Trp Pro Pro Pro Leu Thr Ala Ile His Thr
                325                 330                 335     
Pro Cys Lys Thr Glu Pro Ser Lys Phe Pro Phe Pro Thr Lys Glu Ser
            340                 345                 350         
Gln Gln Ser Asn Phe Gly Thr Gly Glu Gln Lys Arg Tyr Asn Pro Ser
        355                 360                 365             
Lys Thr Ser Asn Gly His Gln Ser Lys Ser Met Leu Lys Asp Asp Leu
    370                 375                 380                 
Lys Leu Ser Ser Ser Glu Asp Ser Asp Gly Glu Gln Asp Cys Asp Lys
385                 390                 395                 400 
Thr Met Pro Arg Ser Thr Pro Gly Ser Asn Ser Glu Pro Ser His His
                405                 410                 415     
Asn Ser Glu Gly Ala Asp Asn Ser Arg Asp Asp Ser Ser Ser His Ser
            420                 425                 430         
Gly Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Ser Glu Ser Ser Ser
        435                 440                 445             
Ser Asp Ser Glu Ala Asn Glu Pro Ser Gln Ser Ala Ser Pro Glu Pro
    450                 455                 460                 
Glu Pro Pro Pro Thr Asn Lys Trp Gln Leu Asp Asn Trp Leu Asn Lys
465                 470                 475                 480 
Val Asn Pro His Lys Val Ser Pro Ala Ser Ser Val Asp Ser Asn Ile
                485                 490                 495     
Pro Ser Ser Gln Gly Tyr Lys Lys Glu Gly Arg Glu Gln Gly Thr Gly
            500                 505                 510         
Asn Ser Tyr Thr Asp Thr Ser Gly Pro Lys Glu Thr Ser Ser Ala Thr
        515                 520                 525             
Pro Gly Arg Asp Ser Lys Thr Ile Gln Lys Gly Ser Glu Ser Gly Arg
    530                 535                 540                 
Gly Arg Gln Lys Ser Pro Ala Gln Ser Asp Ser Thr Thr Gln Arg Arg
545                 550                 555                 560 
Thr Val Gly Lys Lys Gln Pro Lys Lys Ala Glu Lys Ala Ala Ala Glu
                565                 570                 575     
Glu Pro Arg Gly Gly Leu Lys Ile Glu Ser Glu Thr Pro Val Asp Leu
            580                 585                 590         
Ala Ser Ser Met Pro Ser Ser Arg His Lys Ala Ala Thr Lys Gly Ser
        595                 600                 605             
Arg Lys Pro Asn Ile Lys Lys Glu Ser Lys Ser Ser Pro Arg Pro Thr
    610                 615                 620                 
Ala Glu Lys Lys Lys Tyr Lys Ser Thr Ser Lys Ser Ser Gln Lys Ser
625                 630                 635                 640 
Arg Glu Ile Ile Glu Thr Asp Thr Ser Ser Ser Asp Ser Asp Glu Ser
                645                 650                 655     
Glu Ser Leu Pro Pro Ser Ser Gln Thr Pro Lys Tyr Pro Glu Ser Asn
            660                 665                 670         
Arg Thr Pro Val Lys Pro Ser Ser Val Glu Glu Glu Asp Ser Phe Phe
        675                 680                 685             
Arg Gln Arg Met Phe Ser Pro Met Glu Glu Lys Glu Leu Leu Ser Pro
    690                 695                 700                 
Leu Ser Glu Pro Asp Asp Arg Tyr Pro Leu Ile Val Lys Ile Asp Leu
705                 710                 715                 720 
Asn Leu Leu Thr Arg Ile Pro Gly Lys Pro Tyr Lys Glu Thr Glu Pro
                725                 730                 735     
Pro Lys Gly Glu Lys Lys Asn Val Pro Glu Lys His Thr Arg Glu Ala
            740                 745                 750         
Gln Lys Gln Ala Ser Glu Lys Val Ser Asn Lys Gly Lys Arg Lys His
        755                 760                 765             
Lys Asn Glu Asp Asp Asn Arg Ala Ser Glu Ser Lys Lys Pro Lys Thr
    770                 775                 780                 
Glu Asp Lys Asn Ser Ala Gly His Lys Pro Ser Ser Asn Arg Glu Ser
785                 790                 795                 800 
Ser Lys Gln Ser Ala Ala Lys Glu Lys Asp Leu Leu Pro Ser Pro Ala
                805                 810                 815     
Gly Pro Val Pro Ser Lys Asp Pro Lys Thr Glu His Gly Ser Arg Lys
            820                 825                 830         
Arg Thr Ile Ser Gln Ser Ser Ser Leu Lys Ser Ser Ser Asn Ser Asn
        835                 840                 845             
Lys Glu Thr Ser Gly Ser Ser Lys Asn Ser Ser Ser Thr Ser Lys Gln
    850                 855                 860                 
Lys Lys Thr Glu Gly Lys Thr Ser Ser Ser Ser Lys Glu Val Lys Glu
865                 870                 875                 880 
Lys Ala Pro Ser Ser Ser Ser Asn Cys Pro Pro Ser Ala Pro Thr Leu
                885                 890                 895     
Asp Ser Ser Lys Pro Arg Arg Thr Lys Leu Val Phe Asp Asp Arg Asn
            900                 905                 910         
Tyr Ser Ala Asp His Tyr Leu Gln Glu Ala Lys Lys Leu Lys His Asn
        915                 920                 925             
Ala Asp Ala Leu Ser Asp Arg Phe Glu Lys Ala Val Tyr Tyr Leu Asp
    930                 935                 940                 
Ala Val Val Ser Phe Ile Glu Cys Gly Asn Ala Leu Glu Lys Asn Ala
945                 950                 955                 960 
Gln Glu Ser Lys Ser Pro Phe Pro Met Tyr Ser Glu Thr Val Asp Leu
                965                 970                 975     
Ile Lys Tyr Thr Met Lys Leu Lys Asn Tyr Leu Ala Pro Asp Ala Thr
            980                 985                 990         
Ala Ala Asp Lys Arg Leu Thr Val Leu Cys Leu Arg Cys Glu Ser Leu
        995                 1000                1005            
Leu Tyr Leu Arg Leu Phe Lys Leu Lys Lys Glu Asn Ala Leu Lys Tyr
    1010                1015                1020                
Ser Lys Thr Leu Thr Glu His Leu Lys Asn Ser Tyr Asn Asn Ser Gln
1025                1030                1035                1040
Ala Pro Ser Pro Gly Leu Gly Ser Lys Ala Val Gly Met Pro Ser Pro
                1045                1050                1055    
Val Ser Pro Lys Leu Ser Pro Gly Asn Ser Gly Asn Tyr Ser Ser Gly
            1060                1065                1070        
Ala Ser Ser Ala Ser Ala Ser Gly Ser Ser Val Thr Ile Pro Gln Lys
        1075                1080                1085            
Ile His Gln Met Ala Ala Ser Tyr Val Gln Val Thr Ser Asn Phe Leu
    1090                1095                1100                
Tyr Ala Thr Glu Ile Trp Asp Gln Ala Glu Gln Leu Ser Lys Glu Gln
1105                1110                1115                1120
Lys Glu Phe Phe Ala Glu Leu Asp Lys Val Met Gly Pro Leu Ile Phe
                1125                1130                1135    
Asn Ala Ser Ile Met Thr Asp Leu Val Arg Tyr Thr Arg Gln Gly Leu
            1140                1145                1150        
His Trp Leu Arg Gln Asp Ala Lys Leu Ile Ser
        1155                1160            


<210> 7910
<211> 418
<212> PRT
<213> Homo sapiens

<400> 7910
Met Ala Lys Leu Leu Gln Pro Pro Pro Lys Phe Leu Pro Ser Glu Trp
 1               5                  10                  15      
His Ile Ala Asn Lys Asn Gln Tyr His Arg Ala Asp Ala Gln Arg Ser
            20                  25                  30          
Arg Ser Glu Arg Leu Val Ala Glu Ser Gln Arg Leu Val Asp Glu Ile
        35                  40                  45              
Glu Lys Thr Thr Arg Lys Ser Gln Ser Asp Val Asn Lys Lys Leu Glu
    50                  55                  60                  
Gln Arg Leu Glu Glu Val Gln Phe Trp Lys Lys Glu Leu Asp Asp Lys
65                  70                  75                  80  
Leu Glu Gln Leu Val Asn Val Thr Asp Asp Leu Leu Ile Tyr Lys Ile
                85                  90                  95      
Arg Leu Glu Lys Ala Leu Glu Thr Leu Lys Glu Pro Leu His Ile Thr
            100                 105                 110         
Glu Thr Cys Leu Ala Tyr Arg Glu Lys Arg Ile Gly Ile Asp Leu Val
        115                 120                 125             
His Asp Thr Val Glu His Glu Leu Ile Lys Glu Ala Glu Ile Ile Gln
    130                 135                 140                 
Gly Ile Met Ala Leu Leu Thr Arg Thr Leu Glu Glu Ala Ser Glu Gln
145                 150                 155                 160 
Ile Arg Met Asn Arg Ser Ala Lys Tyr Asn Leu Glu Lys Asp Leu Lys
                165                 170                 175     
Asp Lys Phe Val Ala Leu Thr Ile Asp Asp Ile Cys Phe Ser Leu Asn
            180                 185                 190         
Asn Asn Ser Pro Asn Ile Arg Tyr Ser Glu Asn Ala Val Arg Ile Glu
        195                 200                 205             
Pro Asn Ser Val Ser Leu Glu Asp Trp Leu Asp Phe Ser Ser Thr Asn
    210                 215                 220                 
Val Glu Lys Ala Asp Lys Gln Arg Asn Asn Ser Leu Met Leu Lys Ala
225                 230                 235                 240 
Leu Val Asp Arg Ile Leu Ser Gln Thr Ala Asn Asp Leu Arg Lys Gln
                245                 250                 255     
Cys Asp Val Val Asp Thr Ala Phe Lys Asn Gly Leu Lys Asp Thr Lys
            260                 265                 270         
Asp Ala Arg Asp Lys Leu Ala Asp His Leu Ala Lys Val Met Glu Glu
        275                 280                 285             
Ile Ala Ser Gln Glu Lys Asn Ile Thr Ala Leu Glu Lys Ala Ile Leu
    290                 295                 300                 
Asp Gln Glu Gly Pro Ala Lys Val Ala His Thr Arg Leu Glu Thr Arg
305                 310                 315                 320 
Thr His Arg Pro Asn Val Glu Leu Cys Arg Asp Val Ala Gln Tyr Arg
                325                 330                 335     
Leu Met Lys Glu Val Gln Glu Ile Thr His Asn Val Ala Arg Leu Lys
            340                 345                 350         
Glu Thr Leu Ala Gln Ala Gln Ala Glu Leu Lys Gly Leu His Arg Arg
        355                 360                 365             
Gln Leu Ala Leu Gln Glu Glu Ile Gln Val Lys Glu Asn Thr Ile Tyr
    370                 375                 380                 
Ile Asp Glu Val Leu Cys Met Gln Met Arg Lys Ser Ile Pro Leu Arg
385                 390                 395                 400 
Asp Gly Glu Asp His Gly Val Trp Ala Gly Gly Leu Arg Pro Asp Ala
                405                 410                 415     
Val Cys
        


<210> 7911
<211> 184
<212> PRT
<213> Homo sapiens

<400> 7911
Met Gly Asn Gly Met Asn Lys Ile Leu Pro Gly Leu Tyr Ile Gly Asn
 1               5                  10                  15      
Phe Lys Asp Ala Arg Asp Ala Glu Gln Leu Ser Lys Asn Lys Val Thr
            20                  25                  30          
His Ile Leu Ser Val His Asp Ser Ala Arg Pro Met Leu Glu Gly Val
        35                  40                  45              
Lys Tyr Leu Cys Ile Pro Ala Ala Asp Ser Pro Ser Gln Asn Leu Thr
    50                  55                  60                  
Arg His Phe Lys Glu Ser Ile Lys Phe Ile His Glu Cys Arg Leu Arg
65                  70                  75                  80  
Gly Glu Ser Cys Leu Val His Cys Leu Ala Gly Val Ser Arg Ser Val
                85                  90                  95      
Thr Leu Val Ile Ala Tyr Ile Met Thr Val Thr Asp Phe Gly Trp Glu
            100                 105                 110         
Asp Ala Leu His Thr Val Arg Ala Gly Arg Ser Cys Ala Asn Pro Asn
        115                 120                 125             
Val Gly Phe Gln Arg Gln Leu Gln Glu Phe Glu Lys His Glu Val His
    130                 135                 140                 
Gln Tyr Arg Gln Trp Leu Lys Glu Glu Tyr Gly Glu Ser Pro Leu Gln
145                 150                 155                 160 
Asp Ala Glu Glu Ala Lys Asn Ile Leu Ala Ala Pro Gly Ile Leu Lys
                165                 170                 175     
Phe Trp Ala Phe Leu Arg Arg Leu
            180                 


<210> 7912
<211> 940
<212> PRT
<213> Homo sapiens

<400> 7912
Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp
 1               5                  10                  15      
Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser
            20                  25                  30          
Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys
        35                  40                  45              
Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val
    50                  55                  60                  
Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr
65                  70                  75                  80  
Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu
                85                  90                  95      
Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn
            100                 105                 110         
Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu
        115                 120                 125             
Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile
    130                 135                 140                 
Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg
145                 150                 155                 160 
Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr
                165                 170                 175     
Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg
            180                 185                 190         
Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe
        195                 200                 205             
Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys
    210                 215                 220                 
Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro
225                 230                 235                 240 
Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr
                245                 250                 255     
Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala
            260                 265                 270         
Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly
        275                 280                 285             
Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys
    290                 295                 300                 
Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser
305                 310                 315                 320 
Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser
                325                 330                 335     
Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro
            340                 345                 350         
Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala
        355                 360                 365             
Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly
    370                 375                 380                 
Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr
385                 390                 395                 400 
Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp
                405                 410                 415     
Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala
            420                 425                 430         
Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg
        435                 440                 445             
Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro
    450                 455                 460                 
Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser
465                 470                 475                 480 
Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu
                485                 490                 495     
Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr
            500                 505                 510         
Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met
        515                 520                 525             
Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly
    530                 535                 540                 
Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn
545                 550                 555                 560 
Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly
                565                 570                 575     
Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro
            580                 585                 590         
Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp
        595                 600                 605             
Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro
    610                 615                 620                 
Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met
625                 630                 635                 640 
Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly
                645                 650                 655     
Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro
            660                 665                 670         
Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg
        675                 680                 685             
Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His
    690                 695                 700                 
Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro
705                 710                 715                 720 
Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn
                725                 730                 735     
Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg
            740                 745                 750         
Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg
        755                 760                 765             
Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His
    770                 775                 780                 
Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His
785                 790                 795                 800 
Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His
                805                 810                 815     
Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His
            820                 825                 830         
Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His
        835                 840                 845             
Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val
    850                 855                 860                 
Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His
865                 870                 875                 880 
Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His
                885                 890                 895     
Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys
            900                 905                 910         
Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala
        915                 920                 925             
Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro
    930                 935                 940 


<210> 7913
<211> 940
<212> PRT
<213> Homo sapiens

<400> 7913
Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp
 1               5                  10                  15      
Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser
            20                  25                  30          
Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys
        35                  40                  45              
Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val
    50                  55                  60                  
Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr
65                  70                  75                  80  
Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu
                85                  90                  95      
Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn
            100                 105                 110         
Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu
        115                 120                 125             
Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile
    130                 135                 140                 
Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg
145                 150                 155                 160 
Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr
                165                 170                 175     
Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg
            180                 185                 190         
Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe
        195                 200                 205             
Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys
    210                 215                 220                 
Glu Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro
225                 230                 235                 240 
Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr
                245                 250                 255     
Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala
            260                 265                 270         
Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly
        275                 280                 285             
Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys
    290                 295                 300                 
Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser
305                 310                 315                 320 
Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser
                325                 330                 335     
Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro
            340                 345                 350         
Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala
        355                 360                 365             
Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly
    370                 375                 380                 
Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr
385                 390                 395                 400 
Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp
                405                 410                 415     
Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala
            420                 425                 430         
Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg
        435                 440                 445             
Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro
    450                 455                 460                 
Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser
465                 470                 475                 480 
Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu
                485                 490                 495     
Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr
            500                 505                 510         
Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met
        515                 520                 525             
Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly
    530                 535                 540                 
Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn
545                 550                 555                 560 
Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly
                565                 570                 575     
Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro
            580                 585                 590         
Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp
        595                 600                 605             
Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro
    610                 615                 620                 
Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met
625                 630                 635                 640 
Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly
                645                 650                 655     
Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro
            660                 665                 670         
Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg
        675                 680                 685             
Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His
    690                 695                 700                 
Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro
705                 710                 715                 720 
Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn
                725                 730                 735     
Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg
            740                 745                 750         
Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg
        755                 760                 765             
Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His
    770                 775                 780                 
Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His
785                 790                 795                 800 
Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His
                805                 810                 815     
Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His
            820                 825                 830         
Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His
        835                 840                 845             
Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Leu His Asp Val
    850                 855                 860                 
Pro Gly His Arg Gly His Asp His Arg Gly Gln Pro Pro His Glu His
865                 870                 875                 880 
Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His
                885                 890                 895     
Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys
            900                 905                 910         
Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala
        915                 920                 925             
Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro
    930                 935                 940 


<210> 7914
<211> 557
<212> PRT
<213> Homo sapiens

<400> 7914
Met Asp Asp Cys Gly Lys Leu Lys Lys Tyr Lys Glu Leu Thr Leu Thr
 1               5                  10                  15      
Arg Asn Gln Gly Ile Cys Gly Lys Asn Asn Ser Tyr Ile Glu His Gln
            20                  25                  30          
Ile His Gln Val Arg Phe Gly Arg His Arg Glu Glu Cys Asn Tyr Phe
        35                  40                  45              
Leu Val Val Tyr Gln Asn Pro Ile Ile Ser Glu Asp Pro Leu Asp Leu
    50                  55                  60                  
Trp Leu Leu Gly Phe Glu Glu Pro Gly Val Thr Ser Asn Leu Asp Ile
65                  70                  75                  80  
Tyr Arg Val Ser Arg Leu Arg Pro Phe Ile Val Ala Leu Asn Met Asp
                85                  90                  95      
Ser Asp Asp Leu Gln Val Phe Gln Asn Glu Leu Ile Cys Cys Ile Cys
            100                 105                 110         
Val Asn Tyr Phe Ile Asp Pro Val Thr Ile Asp Cys Gly His Ser Phe
        115                 120                 125             
Cys Arg Pro Cys Leu Cys Leu Cys Ser Glu Glu Gly Arg Ala Pro Met
    130                 135                 140                 
Arg Cys Pro Ser Cys Arg Lys Ile Ser Glu Lys Pro Asn Phe Asn Thr
145                 150                 155                 160 
Asn Val Val Leu Lys Lys Leu Ser Ser Leu Ala Arg Gln Thr Arg Pro
                165                 170                 175     
Gln Asn Ile Asn Ser Ser Asp Asn Ile Cys Val Leu His Glu Glu Thr
            180                 185                 190         
Lys Glu Leu Phe Cys Glu Ala Asp Lys Arg Leu Leu Cys Gly Pro Cys
        195                 200                 205             
Ser Glu Ser Pro Glu His Met Ala His Ser His Ser Pro Ile Gly Trp
    210                 215                 220                 
Ala Ala Glu Glu Cys Arg Glu Lys Leu Ile Lys Glu Met Asp Tyr Leu
225                 230                 235                 240 
Trp Glu Ile Asn Gln Glu Thr Arg Asn Asn Leu Asn Gln Glu Thr Arg
                245                 250                 255     
Thr Phe His Ser Leu Lys Asp Tyr Val Ser Val Arg Lys Arg Ile Ile
            260                 265                 270         
Thr Ile Gln Tyr Gln Lys Met Pro Ile Phe Leu Asp Glu Glu Glu Gln
        275                 280                 285             
Arg His Leu Gln Ala Leu Glu Arg Glu Ala Glu Glu Leu Phe Gln Gln
    290                 295                 300                 
Leu Gln Asp Ser Gln Val Arg Met Thr Gln His Leu Glu Arg Met Lys
305                 310                 315                 320 
Asp Met Tyr Arg Glu Leu Trp Glu Thr Cys His Val Pro Asp Val Glu
                325                 330                 335     
Leu Leu Gln Asp Val Arg Asn Val Ser Ala Ser Ser Gly Pro Gly Asn
            340                 345                 350         
Ile Thr Glu Ala Ile Phe Phe Cys Arg Thr Asp Leu Ala Gln Met Gln
        355                 360                 365             
Lys Pro Gln Pro Val Asn Pro Glu Leu Thr Ser Trp Cys Ile Thr Gly
    370                 375                 380                 
Val Leu Asp Met Leu Asn Asn Phe Arg Val Asp Ser Ala Leu Ser Thr
385                 390                 395                 400 
Glu Met Ile Pro Cys Tyr Ile Ser Leu Ser Glu Asp Val Arg Tyr Val
                405                 410                 415     
Ile Phe Gly Asp Asp His Leu Ser Ala Pro Thr Asp Pro Gln Gly Val
            420                 425                 430         
Asp Ser Phe Ala Val Trp Gly Ala Gln Ala Phe Thr Ser Gly Lys His
        435                 440                 445             
Tyr Trp Glu Val Asp Val Thr Leu Ser Ser Asn Trp Ile Leu Gly Val
    450                 455                 460                 
Cys Gln Asp Ser Arg Thr Ala Asp Ala Asn Phe Val Ile Asp Ser Asp
465                 470                 475                 480 
Glu Arg Phe Phe Leu Ile Ser Ser Lys Arg Ser Asn His Tyr Ser Leu
                485                 490                 495     
Ser Thr Asn Ser Pro Pro Leu Ile Gln Tyr Val Gln Arg Pro Leu Gly
            500                 505                 510         
Gln Val Gly Val Phe Leu Asp Tyr Asp Asn Gly Ser Val Ser Phe Phe
        515                 520                 525             
Asp Val Ser Lys Gly Ser Leu Ile Tyr Gly Phe Pro Pro Ser Ser Phe
    530                 535                 540                 
Ser Ser Pro Leu Arg Pro Phe Phe Cys Phe Gly Cys Thr
545                 550                 555         


<210> 7915
<211> 1372
<212> PRT
<213> Homo sapiens

<400> 7915
Asp Gly Leu Ala Tyr Arg Gly Arg Val Phe Leu Glu Leu Ile Thr Gln
 1               5                  10                  15      
Ile Lys Ser Tyr Gln Asp Ser Thr Ile Lys Asp Leu Ser His Glu Val
            20                  25                  30          
Thr Arg Ile Glu Lys His Gln Asn Arg Gln Lys Tyr Gly Leu Cys Val
        35                  40                  45              
Ile Phe Leu Ser Cys Thr Met Met Pro Asn Phe Lys Glu Leu Ile His
    50                  55                  60                  
Phe Glu Val Ser Ile Gly His Tyr Gly Asn Lys Met Asp Leu Asn Tyr
65                  70                  75                  80  
Lys Pro Leu Val Ser Ser Thr Pro Tyr Ser Pro Val Ile Tyr Asp Gly
                85                  90                  95      
Asn Ile Tyr His Tyr Val Pro Trp Tyr Asn Thr Lys Pro Val Val Ala
            100                 105                 110         
Val Thr Ser Asn Trp Glu Asp Val Ser Phe Arg Met Asn Cys Leu Asn
        115                 120                 125             
Leu Leu His Phe Thr Arg Asp Arg Leu Val Ser Gly Ala Gly Ala Asp
    130                 135                 140                 
Ala Gly Lys Thr Pro Val Ser Asp Arg Glu Val Gln Pro Leu Leu Pro
145                 150                 155                 160 
Cys Pro Gly His Arg Arg Pro Leu Pro Cys Met Thr Tyr Gln Pro Lys
                165                 170                 175     
Ala Thr Ser Leu Asp Arg Lys Arg Trp Gln Leu Arg Ser Leu Leu Leu
            180                 185                 190         
Gln Glu Leu Ala Gln Lys Ala Lys Gln Ala Lys Pro Lys Asp Met Val
        195                 200                 205             
Ala Thr Ala Glu Asp Trp Leu Tyr Arg Leu Asn Thr Val Leu Pro Glu
    210                 215                 220                 
Pro Gln Met Gly Leu Pro Asp Val Met Ile Trp Leu Val Ala Lys Glu
225                 230                 235                 240 
Gln Arg Val Ala Tyr Ala Gln Val Pro Ala His Ser Val Leu Phe Ser
                245                 250                 255     
Pro Ala Gly Ala Leu His Ser Gly Arg Leu Cys Gly Lys Ile Gln Thr
            260                 265                 270         
Leu Phe Leu Gln Tyr Pro Glu Gly Glu Gly Gln Lys Asp Val Leu Pro
        275                 280                 285             
Ala His Leu Arg Val Cys Met Trp Leu Gly Asn Val Thr Asp Ser Lys
    290                 295                 300                 
Asp Leu Gln Leu Leu Arg Gln Gly Asp Thr Ala Val Tyr Ala Glu Met
305                 310                 315                 320 
Tyr Glu Asn Gln Ala Lys Tyr Lys Asp Gln Trp Gly Gln Gln Gly Leu
                325                 330                 335     
Tyr His Cys Pro Asn Phe Ser Asp Val Met Gly Asn Lys Thr Leu Pro
            340                 345                 350         
Met Thr Asp Phe Gln Pro Pro Leu Gly Trp His Trp Gln Asp Ser Trp
        355                 360                 365             
Thr Val Glu Pro Gln Arg Arg Leu Leu Leu Asp Ile Asp Ile Asn Lys
    370                 375                 380                 
Ser Gln Val Leu Glu Glu Val Tyr Glu Asn Gln Gly Arg Asp Thr Arg
385                 390                 395                 400 
Gly Ala Trp Gly Pro Ala Ala Ile Pro Asn Thr Asp Val Asn Gly Gln
                405                 410                 415     
Pro Met Glu Ala Arg Glu Asn Val Lys Cys Pro Gln Gly Trp His Phe
            420                 425                 430         
Lys Lys Asp Trp Val Val Glu Leu Asn His Ala Val Asp Ser Lys Gly
        435                 440                 445             
Trp Glu Tyr Gly Val Gly Ile Pro Pro Ser Gly Leu Pro Gln Val Trp
    450                 455                 460                 
Ser Pro Val Glu Lys Thr Tyr His Ser Cys Arg Arg Arg Arg Trp Ala
465                 470                 475                 480 
Arg Val Arg Phe Arg Asn His Gly Glu Leu Ser His Glu Gln Glu Thr
                485                 490                 495     
Leu Ser Phe Leu Gln Leu Gly Leu Ala Lys Gly Glu Glu Glu Gly Trp
            500                 505                 510         
Glu Tyr Asp Thr Phe Gly Ser Lys Phe His Leu Asn Pro Gln Pro Gln
        515                 520                 525             
Ser Arg Phe Arg Arg Arg Cys Trp Arg Arg Arg Leu Ala Pro Asn Lys
    530                 535                 540                 
Asp Lys Gly Ile Ala Pro Ile Phe Leu Leu Glu Gly Ser Leu Val Lys
545                 550                 555                 560 
Pro His Arg Leu Gly Asp Ala Cys Leu Asp Pro Gln Arg Gln Asp Thr
                565                 570                 575     
Arg Pro Pro Asn Leu Pro Phe Ile Tyr Cys Thr Phe Asn Lys Pro His
            580                 585                 590         
Tyr Tyr Gln Leu Phe Cys Tyr Ile Tyr Gln Ala Arg Asn Leu Val Ser
        595                 600                 605             
Asn Gln Ile Leu Thr Phe Gln Gly Pro Phe Ile Arg Val Val Phe Leu
    610                 615                 620                 
Asn His Ser Gln Cys Thr Gln Thr Leu Arg Ser Ser Ala Gly Pro Thr
625                 630                 635                 640 
Trp Ala Gln Thr Leu Ile Phe Gln His Leu Leu Leu Tyr Glu Asn Pro
                645                 650                 655     
Gln Asp Thr Lys Glu Ser Pro Pro Leu Val Val Leu Glu Leu Trp Gln
            660                 665                 670         
Arg Asp Phe Trp Gly Lys Glu Ser Leu Trp Gly Arg Ser Val Trp Pro
        675                 680                 685             
Pro Met Val Trp Leu Asp Leu Gln Asp Arg Ile Leu Pro Pro Met Arg
    690                 695                 700                 
Trp His Pro Leu Val Lys Glu Leu Gly Lys Glu Glu Gly Glu Ile Leu
705                 710                 715                 720 
Ala Ser Cys Glu Leu Ile Leu Gln Thr Glu Val Leu Gly Glu Arg Ala
                725                 730                 735     
Trp Leu Gly Lys Gly Leu Met Leu Pro Ala Leu Pro Gln Lys Leu Gly
            740                 745                 750         
Glu Lys Gln Leu Pro Ile Leu Ser Val Pro Trp Lys Asn Gly Ala Tyr
        755                 760                 765             
Thr Leu Pro Lys Ser Ile Gln Pro Thr Ile Lys Arg Met Ala Ile Glu
    770                 775                 780                 
Ile Leu Ala Trp Gly Leu Arg Asn Met Lys Lys Ala Ser Ser Pro Gln
785                 790                 795                 800 
Leu Leu Val Glu Phe Gly Glu Glu Ser Leu Arg Thr Glu Pro Ile Arg
                805                 810                 815     
Asp Phe Gln Thr Asn Pro Asn Phe Pro Glu Ser Glu Ser Val Leu Val
            820                 825                 830         
Leu Thr Val Leu Met Pro Thr Glu Glu Ala Tyr Ala Leu Pro Leu Val
        835                 840                 845             
Val Lys Val Val Asp Asn Trp Ala Phe Gly Gln Gln Thr Val Thr Gly
    850                 855                 860                 
Gln Ala Asn Ile Asp Phe Leu Gln Pro Tyr Phe Cys Asp Pro Trp Ala
865                 870                 875                 880 
Gln Asp Tyr Met His Pro Lys Leu Pro Arg Arg Trp Gly Ala Ala Pro
                885                 890                 895     
Ala Arg Gly Gln Asn Asp Pro Leu Leu Cys Gln Asp Glu Tyr Glu His
            900                 905                 910         
Glu Val Asp Trp Trp Ser Lys Leu Phe Trp Ala Thr Asp Glu His Lys
        915                 920                 925             
Ser Leu Lys Tyr Lys Tyr Lys Asp Tyr His Thr Leu Lys Val Tyr Glu
    930                 935                 940                 
Cys Glu Leu Glu Ala Val Pro Ala Phe Gln Gly Leu Gln Asp Phe Cys
945                 950                 955                 960 
Gln Thr Phe Lys Leu Tyr Gln Glu Gln Pro Lys Leu Asp Ser Pro Val
                965                 970                 975     
Val Gly Glu Phe Lys Gly Leu Phe Arg Ile Tyr Pro Phe Pro Glu Asn
            980                 985                 990         
Pro Glu Ala Pro Lys Pro Pro Leu Gln Phe Leu Val Trp Pro Glu Arg
        995                 1000                1005            
Glu Asp Phe Pro Gln Pro Cys Leu Val Arg Val Tyr Met Val Arg Ala
    1010                1015                1020                
Ile Asn Leu Gln Pro Gln Asp Tyr Asn Gly Leu Cys Asp Pro Tyr Val
1025                1030                1035                1040
Ile Leu Lys Leu Gly Lys Thr Glu Leu Gly Asn Arg Asp Met Tyr Gln
                1045                1050                1055    
Pro Asn Thr Leu Asp Pro Ile Phe Gly Met Met Phe Glu Leu Thr Cys
            1060                1065                1070        
Asn Ile Pro Leu Glu Lys Asp Leu Glu Ile Gln Leu Tyr Asp Phe Asp
        1075                1080                1085            
Leu Phe Ser Pro Asp Asp Lys Ile Gly Thr Thr Val Ile Asp Leu Glu
    1090                1095                1100                
Asn Arg Leu Leu Ser Gly Phe Gly Ala His Cys Gly Leu Ser Lys Ser
1105                1110                1115                1120
Tyr Cys Gln Ser Gly Pro Phe Arg Trp Arg Asp Gln Met Pro Pro Ser
                1125                1130                1135    
Tyr Leu Leu Glu Arg Tyr Ala Lys Arg Lys Gly Leu Pro Pro Pro Leu
            1140                1145                1150        
Phe Ser Pro Glu Glu Asp Ala Val Phe Tyr Asn Gly Lys Lys Phe Lys
        1155                1160                1165            
Leu Gln Ser Phe Glu Pro Lys Thr Pro Thr Val His Gly Leu Gly Pro
    1170                1175                1180                
Lys Lys Glu Arg Leu Ala Leu Tyr Leu Leu His Thr Gln Gly Leu Val
1185                1190                1195                1200
Pro Glu His Val Glu Thr Arg Thr Leu Tyr Ser His Ser Gln Pro Gly
                1205                1210                1215    
Ile Asp Gln Gly Lys Val Gln Met Trp Val Asp Ile Phe Pro Lys Lys
            1220                1225                1230        
Leu Gly Pro Pro Gly Pro Gln Val Asn Ile Asn Pro Arg Lys Pro Lys
        1235                1240                1245            
Arg Tyr Glu Leu Arg Cys Ile Ile Trp Lys Thr Ala Asn Val Asp Leu
    1250                1255                1260                
Val Asp Asp Asn Leu Ser Arg Glu Lys Thr Ser Asp Ile Tyr Ile Lys
1265                1270                1275                1280
Gly Trp Leu Tyr Gly Leu Glu Lys Asp Met Gln Lys Thr Asp Ile His
                1285                1290                1295    
Tyr His Ser Leu Thr Gly Glu Ala Asp Phe Asn Trp Arg Phe Ile Phe
            1300                1305                1310        
Thr Met Asp Tyr Leu Ala Ala Glu Arg Thr Cys Val Gln Ser Gln Lys
        1315                1320                1325            
Asp Tyr Ile Trp Ser Leu Asp Ala Thr Ser Met Lys Phe Pro Ala Arg
    1330                1335                1340                
Leu Ile Ile Gln Val Trp Asp Asn Asp Ile Phe Ser Pro Asp Asp Phe
1345                1350                1355                1360
Leu Gly Val Leu Glu Leu Asp Leu Ser Asp Met Pro
                1365                1370        


<210> 7916
<211> 1252
<212> PRT
<213> Homo sapiens

<400> 7916
Met Leu Arg Leu Val Val Gln Ser Ala Lys Ile Asp Pro Pro Leu Ala
 1               5                  10                  15      
Pro Leu Pro Arg Pro Cys Met Ser Ile Asp Phe Arg Asp Ile Lys Lys
            20                  25                  30          
Arg Thr Arg Val Val Glu Gly Asn Asp Pro Val Trp Asn Glu Thr Leu
        35                  40                  45              
Ile Trp His Leu Trp Asn Arg Pro Leu Glu Asn Asp Ser Phe Leu Gln
    50                  55                  60                  
Val Thr Leu Gln Asp Met Gly Ser Gln Lys Lys Glu Arg Phe Ile Gly
65                  70                  75                  80  
Leu Ala Thr Val Leu Leu Lys Pro Leu Leu Lys Gln Pro Ser Glu Val
                85                  90                  95      
Leu Phe Val Lys Asp Leu Thr Leu Leu Asn His Ser Met Lys Pro Thr
            100                 105                 110         
Asp Cys Thr Val Thr Leu Gln Val Ala His Met Ser Asn Gln Asp Ile
        115                 120                 125             
Glu Lys Thr Gly Ala Glu Asp His Leu Gly Ile Thr Ala Arg Glu Ala
    130                 135                 140                 
Ala Ser Gln Lys Leu Met Val Pro Gly Ser Thr Ala His Arg Ala Leu
145                 150                 155                 160 
Ser Ser Lys Pro Gln His Phe Gln Val Arg Val Lys Val Phe Glu Ala
                165                 170                 175     
Arg Gln Leu Met Gly Asn Asn Ile Lys Pro Val Val Lys Val Ser Ile
            180                 185                 190         
Ala Gly Gln Gln His Gln Thr Arg Ile Lys Met Gly Asn Asn Pro Phe
        195                 200                 205             
Phe Asn Glu Ile Phe Phe Gln Asn Phe His Glu Val Pro Ala Lys Phe
    210                 215                 220                 
Phe Asp Glu Thr Ile Leu Ile Gln Thr Asp Ile Gly Phe Ile Tyr His
225                 230                 235                 240 
Ser Pro Gly His Thr Leu Leu Arg Lys Trp Leu Gly Leu Cys Gln Pro
                245                 250                 255     
Asn Asn Pro Gly Ser Gly Val Thr Gly Tyr Leu Lys Val Thr Ile Tyr
            260                 265                 270         
Ala Leu Gly Val Gly Asp Gln Ala Leu Ile Asp Gln Lys Leu Leu Tyr
        275                 280                 285             
Gly Thr Asp Asp Thr Asp Ile Gln Ile Phe Lys Ser Ala Val Val Pro
    290                 295                 300                 
Ile Asn Met Ala Tyr Leu Gln Leu Phe Ile Tyr Cys Ala Glu Asp Leu
305                 310                 315                 320 
His Leu Arg Val Tyr Ser Gly Phe Leu Pro Cys Phe Gly Pro Ser Phe
                325                 330                 335     
Leu Thr Leu His Gly Gly Lys Lys Ala Pro Phe Arg Ile Gln Glu Glu
            340                 345                 350         
Gly Ala Cys Ile Pro Asp Ser Val Arg Asp Gly Leu Ala Tyr Arg Gly
        355                 360                 365             
Arg Val Phe Leu Glu Leu Ile Thr Gln Ile Lys Ser Tyr Gln Asp Ser
    370                 375                 380                 
Thr Ile Lys Asp Leu Ser His Glu Val Thr Arg Ile Glu Lys His Gln
385                 390                 395                 400 
Asn Arg Gln Lys Tyr Gly Leu Cys Val Ile Phe Leu Ser Cys Thr Met
                405                 410                 415     
Met Pro Asn Phe Lys Glu Leu Ile His Phe Glu Val Ser Ile Gly His
            420                 425                 430         
Tyr Gly Asn Lys Met Asp Leu Asn Tyr Lys Pro Leu Val Ser Ser Thr
        435                 440                 445             
Pro Tyr Ser Pro Val Ile Tyr Asp Gly Asn Ile Tyr His Tyr Val Pro
    450                 455                 460                 
Trp Tyr Asn Thr Lys Pro Val Val Ala Val Thr Ser Asn Trp Glu Asp
465                 470                 475                 480 
Val Ser Phe Arg Met Asn Cys Leu Asn Leu Leu His Phe Thr Arg Asp
                485                 490                 495     
Arg Leu Lys Ala Asn Leu Asp Thr Leu Lys Ser Thr Arg Asn Pro Lys
            500                 505                 510         
Asp Pro Ala Leu Leu Tyr Gln Trp Glu Lys Leu Leu Arg Glu Leu Ala
        515                 520                 525             
Glu Asp Cys Lys Arg Pro Leu Pro Cys Met Thr Tyr Gln Pro Lys Ala
    530                 535                 540                 
Thr Ser Leu Asp Arg Lys Arg Trp Gln Leu Arg Ser Leu Leu Leu Gln
545                 550                 555                 560 
Glu Leu Ala Gln Lys Ala Lys Gln Ala Lys Pro Lys Asp Met Val Ala
                565                 570                 575     
Thr Ala Glu Asp Trp Leu Tyr Arg Leu Asn Thr Val Leu Pro Glu Pro
            580                 585                 590         
Gln Met Gly Leu Pro Asp Val Met Ile Trp Leu Val Ala Lys Glu Gln
        595                 600                 605             
Arg Val Ala Tyr Ala Gln Val Pro Ala His Ser Val Leu Phe Ser Pro
    610                 615                 620                 
Ala Gly Ala Leu His Ser Gly Arg Leu Cys Gly Lys Ile Gln Thr Leu
625                 630                 635                 640 
Phe Leu Gln Tyr Pro Glu Gly Glu Gly Gln Lys Asp Val Leu Pro Ala
                645                 650                 655     
His Leu Arg Val Cys Met Trp Leu Gly Asn Val Thr Asp Ser Lys Asp
            660                 665                 670         
Leu Gln Leu Leu Arg Gln Gly Asp Thr Ala Val Tyr Ala Glu Met Val
        675                 680                 685             
Tyr Ser Glu Leu Ser Pro Ser Ser Ser Thr Ala Arg Glu Val Ser Lys
    690                 695                 700                 
Ala Leu Thr Cys Arg Gly Leu Thr His His Gln Gln Gly Ser Pro Gly
705                 710                 715                 720 
Pro Leu Gln Ala Pro Val Gly Ser Gln Glu Tyr Glu Asn Gln Ala Lys
                725                 730                 735     
Tyr Lys Asp Gln Trp Gly Gln Gln Gly Leu Tyr His Cys Pro Asn Phe
            740                 745                 750         
Ser Asp Val Met Gly Asn Lys Thr Leu Pro Met Thr Asp Phe Gln Pro
        755                 760                 765             
Pro Leu Gly Trp His Trp Gln Asp Ser Trp Thr Val Glu Pro Gln Arg
    770                 775                 780                 
Arg Leu Leu Leu Asp Ile Asp Ile Asn Lys Ser Gln Val Leu Glu Glu
785                 790                 795                 800 
Val Tyr Glu Asn Gln Gly Arg Asp Thr Arg Gly Ala Trp Gly Pro Ala
                805                 810                 815     
Ala Ile Pro Asn Thr Asp Val Asn Gly Gln Pro Met Glu Ala Arg Glu
            820                 825                 830         
Asn Val Lys Cys Pro Gln Gly Trp His Phe Lys Lys Asp Trp Val Val
        835                 840                 845             
Glu Leu Asn His Ala Val Asp Ser Trp Glu Tyr Gly Val Gly Ile Pro
    850                 855                 860                 
Pro Ser Gly Leu Pro Gln Val Trp Ser Pro Val Glu Lys Thr Tyr His
865                 870                 875                 880 
Ser Cys Arg Arg Arg Arg Trp Ala Arg Val Arg Phe Arg Asn His Gly
                885                 890                 895     
Glu Leu Ser His Glu Gln Glu Thr Leu Ser Phe Leu Gln Leu Gly Leu
            900                 905                 910         
Ala Lys Gly Glu Glu Glu Gly Trp Glu Tyr Asp Thr Phe Gly Ser Lys
        915                 920                 925             
Phe His Leu Asn Pro Gln Pro Gln Ser Arg Phe Arg Arg Arg Cys Trp
    930                 935                 940                 
Arg Arg Arg Leu Ala Pro Asn Lys Asp Lys Gly Ile Ala Pro Ile Phe
945                 950                 955                 960 
Leu Leu Glu Gly Ser Leu Ala Met Asp Leu Lys Tyr His Ala Gly Lys
                965                 970                 975     
Glu Glu Asp Ser Lys Thr Trp Pro Trp Gly Leu Asp Arg Gln Phe Arg
            980                 985                 990         
Asp Pro Gln Arg Gln Asp Thr Arg Pro Pro Asn Leu Pro Phe Ile Tyr
        995                 1000                1005            
Cys Thr Phe Asn Lys Pro His Tyr Tyr Gln Leu Phe Cys Tyr Ile Tyr
    1010                1015                1020                
Gln Ala Arg Asn Leu Val Ser Asn Gln Ile Leu Thr Phe Gln Gly Pro
1025                1030                1035                1040
Phe Ile Arg Val Val Phe Leu Asn His Ser Gln Cys Thr Gln Thr Leu
                1045                1050                1055    
Arg Ser Ser Ala Gly Pro Thr Trp Ala Gln Thr Leu Ile Phe Gln His
            1060                1065                1070        
Leu Leu Leu Tyr Glu Asn Pro Gln Asp Thr Lys Glu Ser Pro Pro Leu
        1075                1080                1085            
Val Val Leu Glu Leu Trp Gln Arg Asp Phe Trp Gly Lys Glu Ser Leu
    1090                1095                1100                
Trp Gly Arg Ser Val Trp Pro Pro Met Val Trp Leu Asp Leu Gln Asp
1105                1110                1115                1120
Arg Ile Leu Pro Pro Met Arg Trp His Pro Leu Val Lys Glu Leu Gly
                1125                1130                1135    
Lys Glu Glu Gly Glu Ile Leu Ala Ser Cys Glu Leu Ile Leu Gln Thr
            1140                1145                1150        
Glu Lys Leu Gly Glu Lys Gln Leu Pro Ile Leu Ser Val Pro Trp Lys
        1155                1160                1165            
Asn Gly Ala Tyr Thr Leu Pro Lys Ser Ile Gln Pro Thr Ile Lys Arg
    1170                1175                1180                
Met Ala Ile Glu Val Leu Ala Met Trp Asp Gly Asp Gly Pro Glu Glu
1185                1190                1195                1200
Ala Gln Ser Gln Gly Ala Ala Ile Ser Trp Gln Asp Ala Arg Ser Leu
                1205                1210                1215    
Asn Gly His Gly Val Leu Asn Glu Leu Asp Gly Thr Gly Ala Leu Arg
            1220                1225                1230        
Asn Pro Gly Thr Ser Cys Phe Phe Arg Pro Gln Arg Gln Ser Ala Ser
        1235                1240                1245            
Gly Thr Pro Thr
    1250        


<210> 7917
<211> 1398
<212> PRT
<213> Homo sapiens

<400> 7917
Asn Ile Tyr His Tyr Val Pro Trp Tyr Asn Thr Lys Pro Val Val Ala
 1               5                  10                  15      
Val Thr Ser Asn Trp Glu Asp Val Ser Phe Arg Met Asn Cys Leu Asn
            20                  25                  30          
Leu Leu His Phe Thr Arg Asp Arg Leu Lys Ala Asn Leu Asp Thr Leu
        35                  40                  45              
Lys Ser Thr Arg Asn Pro Lys Asp Pro Ala Leu Leu Tyr Gln Trp Glu
    50                  55                  60                  
Lys Leu Leu Arg Glu Leu Ala Glu Asp Cys Lys Arg Pro Leu Pro Cys
65                  70                  75                  80  
Met Thr Tyr Gln Pro Lys Ala Thr Ser Leu Asp Arg Lys Arg Trp Gln
                85                  90                  95      
Leu Arg Ser Leu Leu Leu Gln Glu Leu Ala Gln Lys Ala Lys Gln Ala
            100                 105                 110         
Lys Pro Lys Asp Met Val Ala Thr Ala Glu Asp Trp Leu Tyr Arg Leu
        115                 120                 125             
Asn Thr Val Leu Pro Glu Pro Gln Met Gly Leu Pro Asp Val Met Ile
    130                 135                 140                 
Trp Leu Val Ala Lys Glu Gln Arg Val Ala Tyr Ala Gln Val Pro Ala
145                 150                 155                 160 
His Ser Val Leu Phe Ser Pro Ala Gly Ala Leu His Ser Gly Arg Leu
                165                 170                 175     
Cys Gly Lys Ile Gln Thr Leu Phe Leu Gln Tyr Pro Glu Gly Glu Gly
            180                 185                 190         
Gln Lys Asp Val Leu Pro Ala His Leu Arg Val Cys Met Trp Leu Gly
        195                 200                 205             
Asn Val Thr Asp Ser Lys Asp Leu Gln Leu Leu Arg Gln Gly Asp Thr
    210                 215                 220                 
Ala Val Tyr Ala Glu Met Tyr Glu Asn Gln Ala Lys Tyr Lys Asp Gln
225                 230                 235                 240 
Trp Gly Gln Gln Gly Leu Tyr His Cys Pro Asn Phe Ser Asp Val Met
                245                 250                 255     
Gly Asn Lys Thr Leu Pro Met Thr Asp Phe Gln Pro Pro Leu Gly Trp
            260                 265                 270         
His Trp Gln Asp Ser Trp Thr Val Glu Pro Gln Arg Arg Leu Leu Leu
        275                 280                 285             
Asp Ile Asp Ile Asn Lys Ser Gln Val Leu Glu Glu Val Tyr Glu Asn
    290                 295                 300                 
Gln Gly Arg Asp Thr Arg Gly Ala Trp Gly Pro Ala Ala Ile Pro Asn
305                 310                 315                 320 
Thr Asp Val Asn Gly Gln Pro Met Glu Ala Arg Glu Asn Val Lys Cys
                325                 330                 335     
Pro Gln Gly Trp His Phe Lys Lys Asp Trp Val Val Glu Leu Asn His
            340                 345                 350         
Ala Val Asp Ser Lys Gly Trp Glu Tyr Gly Val Gly Ile Pro Pro Ser
        355                 360                 365             
Gly Leu Pro Gln Val Trp Ser Pro Val Glu Lys Thr Tyr His Ser Cys
    370                 375                 380                 
Arg Arg Arg Arg Trp Ala Arg Val Arg Phe Arg Asn His Gly Glu Leu
385                 390                 395                 400 
Ser His Glu Gln Glu Thr Leu Ser Phe Leu Gln Leu Gly Leu Ala Lys
                405                 410                 415     
Gly Glu Glu Glu Gly Trp Glu Tyr Asp Thr Phe Gly Ser Lys Phe His
            420                 425                 430         
Leu Asn Pro Gln Pro Gln Ser Arg Phe Arg Arg Arg Cys Trp Arg Arg
        435                 440                 445             
Arg Leu Ala Pro Asn Lys Asp Lys Gly Ile Ala Pro Ile Phe Leu Leu
    450                 455                 460                 
Glu Gly Ser Leu Val Lys Pro His Arg Leu Gly Asp Ala Cys Leu Asp
465                 470                 475                 480 
Pro Gln Arg Gln Asp Thr Arg Pro Pro Asn Leu Pro Phe Ile Tyr Cys
                485                 490                 495     
Thr Phe Asn Lys Pro His Tyr Tyr Gln Leu Phe Cys Tyr Ile Tyr Gln
            500                 505                 510         
Ala Arg Asn Leu Val Ser Asn Gln Ile Leu Thr Phe Gln Gly Pro Phe
        515                 520                 525             
Ile Arg Val Val Phe Leu Asn His Ser Gln Cys Thr Gln Thr Leu Arg
    530                 535                 540                 
Ser Ser Ala Gly Pro Thr Trp Ala Gln Thr Leu Ile Phe Gln His Leu
545                 550                 555                 560 
Leu Leu Tyr Glu Asn Pro Gln Asp Thr Lys Glu Ser Pro Pro Leu Val
                565                 570                 575     
Val Leu Glu Leu Trp Gln Arg Asp Phe Trp Gly Lys Glu Ser Leu Trp
            580                 585                 590         
Gly Arg Ser Val Trp Pro Pro Met Val Trp Leu Asp Leu Gln Asp Arg
        595                 600                 605             
Ile Leu Pro Pro Met Arg Trp His Pro Leu Val Lys Glu Leu Gly Lys
    610                 615                 620                 
Glu Glu Gly Glu Ile Leu Ala Ser Cys Glu Leu Ile Leu Gln Thr Glu
625                 630                 635                 640 
Val Leu Gly Glu Arg Ala Trp Leu Gly Lys Gly Leu Met Leu Pro Ala
                645                 650                 655     
Leu Pro Gln Lys Leu Gly Glu Lys Gln Leu Pro Ile Leu Ser Val Pro
            660                 665                 670         
Trp Lys Asn Gly Ala Tyr Thr Leu Pro Lys Ser Ile Gln Pro Thr Ile
        675                 680                 685             
Lys Arg Met Ala Ile Glu Ile Leu Ala Trp Gly Leu Arg Asn Met Lys
    690                 695                 700                 
Lys Ala Ser Ser Pro Gln Leu Leu Val Glu Phe Gly Glu Glu Ser Leu
705                 710                 715                 720 
Arg Thr Glu Pro Ile Arg Asp Phe Gln Thr Asn Pro Asn Phe Pro Glu
                725                 730                 735     
Ser Glu Ser Val Leu Val Leu Thr Val Leu Met Pro Thr Glu Glu Ala
            740                 745                 750         
Tyr Ala Leu Pro Leu Val Val Lys Val Val Asp Asn Trp Ala Phe Gly
        755                 760                 765             
Gln Gln Thr Val Thr Gly Gln Ala Asn Ile Asp Phe Leu Gln Pro Tyr
    770                 775                 780                 
Phe Cys Asp Pro Trp Ala Gln Asp Tyr Met His Pro Lys Leu Pro Arg
785                 790                 795                 800 
Arg Trp Gly Ala Ala Pro Ala Arg Gly Gln Asn Asp Pro Leu Leu Cys
                805                 810                 815     
Gln Asp Glu Tyr Glu His Glu Val Asp Trp Trp Ser Lys Leu Phe Trp
            820                 825                 830         
Ala Thr Asp Glu His Lys Ser Leu Lys Tyr Lys Tyr Lys Asp Tyr His
        835                 840                 845             
Thr Leu Lys Val Tyr Glu Cys Glu Leu Glu Ala Val Pro Ala Phe Gln
    850                 855                 860                 
Gly Leu Gln Asp Phe Cys Gln Thr Phe Lys Leu Tyr Gln Glu Gln Pro
865                 870                 875                 880 
Lys Leu Asp Ser Pro Val Val Gly Glu Phe Lys Gly Leu Phe Arg Ile
                885                 890                 895     
Tyr Pro Phe Pro Glu Asn Pro Glu Ala Pro Lys Pro Pro Leu Gln Phe
            900                 905                 910         
Leu Val Trp Pro Glu Arg Glu Asp Phe Pro Gln Pro Cys Leu Val Arg
        915                 920                 925             
Val Tyr Met Val Arg Ala Ile Asn Leu Gln Pro Gln Asp Tyr Asn Gly
    930                 935                 940                 
Leu Cys Asp Pro Tyr Val Ile Leu Lys Leu Gly Lys Thr Glu Leu Gly
945                 950                 955                 960 
Asn Arg Asp Met Tyr Gln Pro Asn Thr Leu Asp Pro Ile Phe Gly Met
                965                 970                 975     
Met Phe Glu Leu Thr Cys Asn Ile Pro Leu Glu Lys Asp Leu Glu Ile
            980                 985                 990         
Gln Leu Tyr Asp Phe Asp Leu Phe Ser Pro Asp Asp Lys Ile Gly Thr
        995                 1000                1005            
Thr Val Ile Asp Leu Glu Asn Arg Leu Leu Ser Gly Phe Gly Ala His
    1010                1015                1020                
Cys Gly Leu Ser Lys Ser Tyr Cys Gln Ser Gly Pro Phe Arg Trp Arg
1025                1030                1035                1040
Asp Gln Met Pro Pro Ser Tyr Leu Leu Glu Arg Tyr Ala Lys Arg Lys
                1045                1050                1055    
Gly Leu Pro Pro Pro Leu Phe Ser Pro Glu Glu Asp Ala Val Phe Tyr
            1060                1065                1070        
Asn Gly Lys Lys Phe Lys Leu Gln Ser Phe Glu Pro Lys Thr Pro Thr
        1075                1080                1085            
Val His Gly Leu Gly Pro Lys Lys Glu Arg Leu Ala Leu Tyr Leu Leu
    1090                1095                1100                
His Thr Gln Gly Leu Val Pro Glu His Val Glu Thr Arg Thr Leu Tyr
1105                1110                1115                1120
Ser His Ser Gln Pro Gly Ile Asp Gln Gly Lys Val Gln Met Trp Val
                1125                1130                1135    
Asp Ile Phe Pro Lys Lys Leu Gly Pro Pro Gly Pro Gln Val Asn Ile
            1140                1145                1150        
Asn Pro Arg Lys Pro Lys Arg Tyr Glu Leu Arg Cys Ile Ile Trp Lys
        1155                1160                1165            
Thr Ala Asn Val Asp Leu Val Asp Asp Asn Leu Ser Arg Glu Lys Thr
    1170                1175                1180                
Ser Asp Ile Tyr Ile Lys Gly Trp Leu Tyr Gly Leu Glu Lys Asp Met
1185                1190                1195                1200
Gln Lys Thr Asp Ile His Tyr His Ser Leu Thr Gly Glu Ala Asp Phe
                1205                1210                1215    
Asn Trp Arg Phe Ile Phe Thr Met Asp Tyr Leu Ala Ala Glu Arg Thr
            1220                1225                1230        
Cys Val Gln Ser Gln Lys Asp Tyr Ile Trp Ser Leu Asp Ala Thr Ser
        1235                1240                1245            
Met Lys Phe Pro Ala Arg Leu Ile Ile Gln Val Trp Asp Asn Asp Ile
    1250                1255                1260                
Phe Ser Pro Asp Asp Phe Leu Gly Val Leu Glu Leu Asp Leu Ser Asp
1265                1270                1275                1280
Met Pro Leu Pro Ala Arg His Ala Lys Gln Cys Ser Ile Arg Met Met
                1285                1290                1295    
Asp Ala Asp Pro Lys Trp Pro Tyr Phe Ile Gln Tyr Lys His Phe Ser
            1300                1305                1310        
Leu Phe Lys Lys Lys Thr Val Thr Gly Trp Trp Pro Cys Gln Val Leu
        1315                1320                1325            
Asp Gly Gly Lys Trp Arg Leu Ser Gly Lys Val Lys Met Ser Leu Glu
    1330                1335                1340                
Ile Leu Ser Glu Lys Glu Ala Leu Ile Lys Pro Ala Gly Arg Gly Gln
1345                1350                1355                1360
Ser Glu Pro Asn Gln Tyr Pro Thr Leu His Pro Pro Leu Arg Thr Asn
                1365                1370                1375    
Thr Ser Phe Thr Trp Leu Arg Ser Pro Val Gln Asn Phe Cys Tyr Ile
            1380                1385                1390        
Phe Trp Lys Arg Tyr Arg
        1395            


<210> 7918
<211> 447
<212> PRT
<213> Homo sapiens

<400> 7918
Met Ala Glu Gly Glu Gly Tyr Phe Ala Met Ser Glu Asp Glu Leu Ala
 1               5                  10                  15      
Cys Ser Pro Tyr Ile Pro Leu Gly Gly Asp Phe Gly Gly Gly Asp Phe
            20                  25                  30          
Gly Gly Gly Asp Phe Gly Gly Gly Asp Phe Gly Gly Gly Asp Phe Gly
        35                  40                  45              
Gly Gly Gly Ser Phe Gly Gly His Cys Leu Asp Tyr Cys Glu Ser Pro
    50                  55                  60                  
Thr Ala His Cys Asn Val Leu Asn Trp Glu Gln Val Gln Arg Leu Asp
65                  70                  75                  80  
Gly Ile Leu Ser Glu Thr Ile Pro Ile His Gly Arg Gly Asn Phe Pro
                85                  90                  95      
Thr Leu Glu Leu Gln Pro Ser Leu Ile Val Lys Val Val Arg Arg Arg
            100                 105                 110         
Leu Ala Glu Lys Arg Ile Gly Val Arg Asp Val Arg Leu Asn Gly Ser
        115                 120                 125             
Ala Ala Ser His Val Leu His Gln Asp Ser Gly Leu Gly Tyr Lys Asp
    130                 135                 140                 
Leu Asp Leu Ile Phe Cys Ala Asp Leu Arg Gly Glu Gly Glu Phe Gln
145                 150                 155                 160 
Thr Val Lys Asp Val Val Leu Asp Cys Leu Leu Asp Phe Leu Pro Glu
                165                 170                 175     
Gly Val Asn Lys Glu Lys Ile Thr Pro Leu Thr Leu Lys Glu Ala Tyr
            180                 185                 190         
Val Gln Lys Met Val Lys Val Cys Asn Asp Ser Asp Arg Trp Ser Leu
        195                 200                 205             
Ile Ser Leu Ser Asn Asn Ser Gly Lys Asn Val Glu Leu Lys Phe Val
    210                 215                 220                 
Asp Ser Leu Arg Arg Gln Phe Glu Phe Ser Val Asp Ser Phe Gln Ile
225                 230                 235                 240 
Lys Leu Asp Ser Leu Leu Leu Phe Tyr Glu Cys Ser Glu Asn Pro Met
                245                 250                 255     
Thr Glu Thr Phe His Pro Thr Ile Ile Gly Glu Ser Val Tyr Gly Asp
            260                 265                 270         
Phe Gln Glu Ala Phe Asp His Leu Cys Asn Lys Ile Ile Ala Thr Arg
        275                 280                 285             
Asn Pro Glu Glu Ile Arg Gly Gly Gly Leu Leu Lys Tyr Cys Asn Leu
    290                 295                 300                 
Leu Val Arg Gly Phe Arg Pro Ala Ser Asp Glu Ile Lys Ala Leu Gln
305                 310                 315                 320 
Arg Tyr Met Cys Ser Arg Phe Phe Ile Asp Phe Ser Asp Ile Gly Glu
                325                 330                 335     
Gln Gln Arg Lys Leu Glu Ser Tyr Leu Gln Asn His Phe Val Gly Leu
            340                 345                 350         
Glu Asp Arg Lys Tyr Glu Tyr Leu Met Thr Leu His Gly Val Val Asn
        355                 360                 365             
Glu Ser Thr Val Cys Leu Met Gly His Glu Arg Arg Gln Thr Leu Asn
    370                 375                 380                 
Leu Ile Thr Met Leu Ala Ile Arg Val Leu Ala Asp Gln Asn Val Ile
385                 390                 395                 400 
Pro Asn Val Ala Asn Val Thr Cys Tyr Tyr Gln Pro Ala Pro Tyr Val
                405                 410                 415     
Ala Asp Ala Asn Phe Ser Asn Tyr Tyr Ile Ala Gln Val Gln Pro Val
            420                 425                 430         
Phe Thr Cys Gln Gln Gln Thr Tyr Ser Thr Trp Leu Pro Cys Asn
        435                 440                 445         


<210> 7919
<211> 890
<212> PRT
<213> Homo sapiens

<400> 7919
Met Val Gln Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val
 1               5                  10                  15      
Pro Cys Lys Leu Glu Pro Asp Arg Phe Cys Gly Gly Gly Arg Asp Ala
            20                  25                  30          
Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Ala Gly
        35                  40                  45              
Gln Glu Leu Cys Gln Pro Arg Cys Ala Phe Ser Thr Leu Gly Arg Val
    50                  55                  60                  
Leu Arg Leu Ala Tyr Ser Glu Ala Gly Asp Tyr Leu Val Ala Ile Glu
65                  70                  75                  80  
Glu Lys Asn Lys Ala Thr Phe Leu Arg Ala Tyr Val Asn Trp Arg Asn
                85                  90                  95      
Lys Arg Thr Glu Asn Ser Arg Val Cys Ile Arg Met Ile Gly His Asn
            100                 105                 110         
Val Glu Gly Pro Phe Ser Lys Ala Phe Arg Asp Gln Met Tyr Ile Ile
        115                 120                 125             
Glu Met Pro Leu Ser Glu Ala Pro Leu Cys Ile Ser Cys Cys Pro Val
    130                 135                 140                 
Lys Gly Asp Leu Leu Val Gly Cys Thr Asn Lys Leu Val Leu Phe Ser
145                 150                 155                 160 
Leu Lys Tyr Gln Ile Ile Asn Glu Glu Phe Ser Leu Leu Asp Phe Glu
                165                 170                 175     
Arg Ser Leu Ile Ile His Ile Asp Asn Ile Thr Pro Val Glu Val Ser
            180                 185                 190         
Phe Cys Val Gly Tyr Val Ala Val Met Ser Asp Leu Glu Val Leu Ile
        195                 200                 205             
Val Lys Leu Glu Ser Gly Pro Lys Asn Gly Glu Arg Val His His His
    210                 215                 220                 
Pro His Lys Thr Asn Asn Arg Ile Arg Arg Thr Glu Glu Gly Ile Ser
225                 230                 235                 240 
Asn Glu Ile Ser Gln Leu Glu Ser Asp Asp Phe Val Ile Cys Gln Lys
                245                 250                 255     
Pro Leu Glu Leu Leu Gly Glu Lys Ser Glu Gln Ser Gly Leu Ser Val
            260                 265                 270         
Thr Leu Glu Ser Thr Gly Leu Ala Asp Glu Lys Arg Lys Tyr Ser His
        275                 280                 285             
Phe Gln His Leu Leu Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr
    290                 295                 300                 
Val Leu Ser Asp Asp Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile
305                 310                 315                 320 
Tyr Gln Thr Gly Ser Leu Thr Ser Asp Gly Lys Asn Leu Ser Gln Glu
                325                 330                 335     
Lys Glu Leu Leu Ser Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly
            340                 345                 350         
Tyr Leu Tyr Met Val Val Lys Ser Val Glu Leu Met Ser Val Tyr Gln
        355                 360                 365             
Tyr Pro Glu Lys Ser Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His
    370                 375                 380                 
Val Ile Thr Ser Asn Asn Leu Gln Cys Phe Thr Val Arg Cys Ser Ala
385                 390                 395                 400 
Ala Ala Ala Arg Glu Glu Asp Pro Tyr Met Asp Thr Thr Leu Lys Ala
                405                 410                 415     
Cys Pro Pro Val Ser Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe
            420                 425                 430         
Ile Gly Leu Lys Ala Ile Cys His Phe Lys Asn His Ile Ile Leu Leu
        435                 440                 445             
Thr Lys Ala Glu Pro Glu Ala Ile Pro Glu Arg Arg Gln Ser Pro Lys
    450                 455                 460                 
Arg Leu Leu Ser Arg Lys Asp Thr Ser Val Lys Ile Lys Ile Pro Pro
465                 470                 475                 480 
Val Ala Glu Ala Gly Trp Asn Leu Tyr Ile Val Asn Thr Ile Ser Pro
                485                 490                 495     
Val Gln Leu Tyr Lys Glu Met Val Asp Tyr Ser Asn Thr Tyr Lys Thr
            500                 505                 510         
Val Lys Thr Gln Ser Cys Ile His Leu Leu Ser Glu Ala His Leu Leu
        515                 520                 525             
Val Arg Ala Ala Leu Met Asp Ala Ser Gln Leu Glu Pro Gly Glu Lys
    530                 535                 540                 
Ala Glu Leu Leu Glu Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp
545                 550                 555                 560 
Cys Tyr Ser Arg Leu Asp Ser Gln His Ser His Leu Thr Leu Pro Tyr
                565                 570                 575     
Tyr Lys Met Ser Gly Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp
            580                 585                 590         
Trp Thr Val Glu Asp Gly Leu Gln Lys Tyr Glu Arg Gly Leu Ile Phe
        595                 600                 605             
Tyr Ile Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu
    610                 615                 620                 
Glu Leu Ala Ala Lys Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys
625                 630                 635                 640 
Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro
                645                 650                 655     
Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser
            660                 665                 670         
Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly
        675                 680                 685             
Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys
    690                 695                 700                 
Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg
705                 710                 715                 720 
Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr
                725                 730                 735     
Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn
            740                 745                 750         
Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala
        755                 760                 765             
Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala
    770                 775                 780                 
Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe
785                 790                 795                 800 
Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro
                805                 810                 815     
Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser
            820                 825                 830         
His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp
        835                 840                 845             
Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Leu
    850                 855                 860                 
Pro Leu Phe Arg Ser Trp Ser His Phe Gln Lys Thr Leu Leu Pro Ala
865                 870                 875                 880 
Ser Val Ser Met Phe Cys Val Val His Ala
                885                 890 


<210> 7920
<211> 1004
<212> PRT
<213> Homo sapiens

<400> 7920
Met Val Gln Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val
 1               5                  10                  15      
Pro Cys Lys Leu Glu Pro Asp Arg Phe Cys Gly Gly Gly Arg Asp Ala
            20                  25                  30          
Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Ala Gly
        35                  40                  45              
Gln Glu Leu Cys Gln Pro Arg Cys Ala Phe Ser Thr Leu Gly Arg Val
    50                  55                  60                  
Leu Arg Leu Ala Tyr Ser Glu Ala Gly Asp Tyr Leu Val Ala Ile Glu
65                  70                  75                  80  
Glu Lys Asn Lys Ala Thr Phe Leu Arg Ala Tyr Val Asn Trp Arg Asn
                85                  90                  95      
Lys Arg Thr Glu Asn Ser Arg Val Cys Ile Arg Met Ile Gly His Asn
            100                 105                 110         
Val Glu Gly Pro Phe Ser Lys Ala Phe Arg Asp Gln Met Tyr Ile Ile
        115                 120                 125             
Glu Met Pro Leu Ser Glu Ala Pro Leu Cys Ile Ser Cys Cys Pro Val
    130                 135                 140                 
Lys Gly Asp Leu Leu Val Gly Cys Thr Asn Lys Leu Val Leu Phe Ser
145                 150                 155                 160 
Leu Lys Tyr Gln Ile Ile Asn Glu Glu Phe Ser Leu Leu Asp Phe Glu
                165                 170                 175     
Arg Ser Leu Ile Ile His Ile Asp Asn Ile Thr Pro Val Glu Val Ser
            180                 185                 190         
Phe Cys Val Gly Tyr Val Ala Val Met Ser Asp Leu Glu Val Leu Ile
        195                 200                 205             
Val Lys Leu Glu Ser Gly Pro Lys Asn Gly Glu Arg Val His His His
    210                 215                 220                 
Pro His Lys Thr Asn Asn Arg Ile Arg Arg Thr Glu Glu Gly Ile Ser
225                 230                 235                 240 
Asn Glu Ile Ser Gln Leu Glu Ser Asp Asp Phe Val Ile Cys Gln Lys
                245                 250                 255     
Pro Leu Glu Leu Leu Gly Glu Lys Ser Glu Gln Ser Gly Leu Ser Val
            260                 265                 270         
Thr Leu Glu Ser Thr Gly Leu Ala Asp Glu Lys Arg Lys Tyr Ser His
        275                 280                 285             
Phe Gln His Leu Leu Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr
    290                 295                 300                 
Val Leu Ser Asp Asp Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile
305                 310                 315                 320 
Tyr Gln Thr Gly Ser Leu Thr Ser Asp Gly Lys Asn Leu Ser Gln Glu
                325                 330                 335     
Lys Glu Leu Leu Ser Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly
            340                 345                 350         
Tyr Leu Tyr Met Val Val Lys Ser Val Glu Leu Met Ser Val Tyr Gln
        355                 360                 365             
Tyr Pro Glu Lys Ser Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His
    370                 375                 380                 
Val Ile Thr Ser Asn Asn Leu Gln Cys Phe Thr Val Arg Cys Ser Ala
385                 390                 395                 400 
Ala Ala Ala Arg Glu Glu Asp Pro Tyr Met Asp Thr Thr Leu Lys Ala
                405                 410                 415     
Cys Pro Pro Val Ser Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe
            420                 425                 430         
Ile Gly Leu Lys Ala Ile Cys His Phe Lys Asn His Ile Ile Leu Leu
        435                 440                 445             
Thr Lys Ala Glu Pro Glu Ala Ile Pro Glu Arg Arg Gln Ser Pro Lys
    450                 455                 460                 
Arg Leu Leu Ser Arg Lys Asp Thr Ser Val Lys Ile Lys Ile Pro Pro
465                 470                 475                 480 
Val Ala Glu Ala Gly Trp Asn Leu Tyr Ile Val Asn Thr Ile Ser Pro
                485                 490                 495     
Val Gln Leu Tyr Lys Glu Met Val Asp Tyr Ser Asn Thr Tyr Lys Thr
            500                 505                 510         
Val Lys Thr Gln Ser Cys Ile His Leu Leu Ser Glu Ala His Leu Leu
        515                 520                 525             
Val Arg Ala Ala Leu Met Asp Ala Ser Gln Leu Glu Pro Gly Glu Lys
    530                 535                 540                 
Ala Glu Leu Leu Glu Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp
545                 550                 555                 560 
Cys Tyr Ser Arg Leu Asp Ser Gln His Ser His Leu Thr Leu Pro Tyr
                565                 570                 575     
Tyr Lys Met Ser Gly Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp
            580                 585                 590         
Trp Thr Val Glu Asp Gly Leu Gln Lys Tyr Glu Arg Gly Leu Ile Phe
        595                 600                 605             
Tyr Ile Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu
    610                 615                 620                 
Glu Leu Ala Ala Lys Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys
625                 630                 635                 640 
Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro
                645                 650                 655     
Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser
            660                 665                 670         
Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly
        675                 680                 685             
Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys
    690                 695                 700                 
Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg
705                 710                 715                 720 
Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr
                725                 730                 735     
Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn
            740                 745                 750         
Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala
        755                 760                 765             
Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala
    770                 775                 780                 
Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe
785                 790                 795                 800 
Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro
                805                 810                 815     
Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser
            820                 825                 830         
His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp
        835                 840                 845             
Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Ser
    850                 855                 860                 
Leu Ile Cys Gly Pro Ser Phe Asp Ile Ala Ser Ile Ile Pro Phe Leu
865                 870                 875                 880 
Glu Pro Leu Ser Glu Asp Thr Ile Ala Gly Leu Ser Val His Val Leu
                885                 890                 895     
Cys Arg Thr Arg Leu Lys Glu Tyr Glu Gln Cys Ile Asp Ile Leu Leu
            900                 905                 910         
Glu Arg Cys Pro Glu Ala Val Ile Pro Tyr Ala Asn His Glu Leu Lys
        915                 920                 925             
Glu Glu Asn Arg Thr Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys
    930                 935                 940                 
Gln Arg Ile Lys Cys Gly Gly Glu Lys Tyr Gln Leu Tyr Leu Ser Ser
945                 950                 955                 960 
Leu Lys Glu Thr Leu Ser Ile Val Ala Val Glu Leu Glu Leu Lys Asp
                965                 970                 975     
Phe Met Asn Val Leu Pro Glu Asp Gly Thr Ala Thr Phe Phe Leu Pro
            980                 985                 990         
Tyr Leu Leu Tyr Cys Ser Arg Lys Lys Pro Leu Thr
        995                 1000                


<210> 7921
<211> 1686
<212> PRT
<213> Homo sapiens

<400> 7921
Met Ala Gln Ile Phe Ser Asn Ser Gly Phe Lys Glu Cys Pro Phe Ser
 1               5                  10                  15      
His Pro Glu Pro Thr Arg Ala Lys Asp Val Asp Lys Glu Glu Ala Leu
            20                  25                  30          
Gln Met Glu Ala Glu Ala Leu Ala Lys Leu Gln Lys Asp Arg Gln Val
        35                  40                  45              
Thr Asp Asn Gln Arg Gly Phe Glu Leu Ser Ser Ser Thr Arg Lys Lys
    50                  55                  60                  
Ala Gln Val Tyr Asn Lys Gln Asp Tyr Asp Leu Met Val Phe Pro Glu
65                  70                  75                  80  
Ser Asp Ser Gln Lys Arg Ala Leu Asp Ile Asp Val Glu Lys Leu Thr
                85                  90                  95      
Gln Ala Glu Leu Glu Lys Leu Leu Leu Asp Asp Ser Phe Glu Thr Lys
            100                 105                 110         
Lys Thr Pro Val Leu Pro Val Thr Pro Ile Leu Ser Pro Ser Phe Ser
        115                 120                 125             
Ala Gln Leu Tyr Phe Arg Pro Thr Ile Gln Arg Gly Gln Trp Pro Pro
    130                 135                 140                 
Gly Leu Pro Gly Pro Ser Thr Tyr Ala Leu Pro Ser Ile Tyr Pro Ser
145                 150                 155                 160 
Thr Tyr Ser Lys Gln Ala Ala Phe Gln Asn Gly Phe Asn Pro Arg Met
                165                 170                 175     
Pro Thr Phe Pro Ser Thr Glu Pro Ile Tyr Leu Ser Leu Pro Gly Gln
            180                 185                 190         
Ser Pro Tyr Phe Ser Tyr Pro Leu Thr Pro Ala Thr Pro Phe His Pro
        195                 200                 205             
Gln Gly Ser Leu Pro Ile Tyr Arg Pro Val Val Ser Thr Asp Met Ala
    210                 215                 220                 
Lys Leu Phe Asp Lys Ile Ala Ser Thr Ser Glu Phe Leu Lys Asn Gly
225                 230                 235                 240 
Lys Ala Arg Thr Asp Leu Glu Ile Thr Asp Ser Lys Val Ser Asn Leu
                245                 250                 255     
Gln Val Ser Pro Lys Ser Glu Asp Ile Ser Lys Phe Asp Trp Leu Asp
            260                 265                 270         
Leu Asp Pro Leu Ser Lys Pro Lys Val Asp Asn Val Glu Val Leu Asp
        275                 280                 285             
His Glu Glu Glu Lys Asn Val Ser Ser Leu Leu Ala Lys Asp Pro Trp
    290                 295                 300                 
Asp Ala Val Leu Leu Glu Glu Arg Ser Thr Ala Asn Cys His Leu Glu
305                 310                 315                 320 
Arg Lys Val Asn Gly Lys Ser Leu Ser Val Ala Thr Val Thr Arg Ser
                325                 330                 335     
Gln Ser Leu Asn Ile Arg Thr Thr Gln Leu Ala Lys Ala Gln Gly His
            340                 345                 350         
Ile Ser Gln Lys Asp Pro Asn Gly Thr Ser Ser Leu Pro Thr Gly Ser
        355                 360                 365             
Ser Leu Leu Gln Glu Val Glu Val Gln Asn Glu Glu Met Ala Ala Phe
    370                 375                 380                 
Cys Arg Ser Ile Thr Lys Leu Lys Thr Lys Phe Pro Tyr Thr Asn His
385                 390                 395                 400 
Arg Thr Asn Pro Gly Tyr Leu Leu Ser Pro Val Thr Ala Gln Arg Asn
                405                 410                 415     
Ile Cys Gly Glu Asn Ala Ser Val Lys Val Ser Ile Asp Ile Glu Gly
            420                 425                 430         
Phe Gln Leu Pro Val Thr Phe Thr Cys Asp Val Ser Ser Thr Val Glu
        435                 440                 445             
Ile Ile Ile Met Gln Ala Leu Cys Trp Val His Asp Asp Leu Asn Gln
    450                 455                 460                 
Val Asp Val Gly Ser Tyr Val Leu Lys Val Cys Gly Gln Glu Glu Val
465                 470                 475                 480 
Leu Gln Asn Asn His Cys Leu Gly Ser His Glu His Ile Gln Asn Cys
                485                 490                 495     
Arg Lys Trp Asp Thr Glu Ile Arg Leu Gln Leu Leu Thr Phe Ser Ala
            500                 505                 510         
Met Cys Gln Asn Leu Ala Arg Thr Ala Glu Asp Asp Glu Thr Pro Val
        515                 520                 525             
Asp Leu Asn Lys His Leu Tyr Gln Ile Glu Lys Pro Cys Lys Glu Ala
    530                 535                 540                 
Met Thr Arg His Pro Val Glu Glu Leu Leu Asp Ser Tyr His Asn Gln
545                 550                 555                 560 
Val Glu Leu Ala Leu Gln Ile Glu Asn Gln His Arg Ala Val Asp Gln
                565                 570                 575     
Val Ile Lys Ala Val Arg Lys Ile Cys Ser Ala Leu Asp Gly Val Glu
            580                 585                 590         
Thr Leu Ala Ile Thr Glu Ser Val Lys Lys Leu Lys Arg Ala Val Asn
        595                 600                 605             
Leu Pro Arg Ser Lys Thr Ala Asp Val Thr Ser Leu Phe Gly Gly Glu
    610                 615                 620                 
Asp Thr Ser Arg Ser Ser Thr Arg Gly Ser Leu Asn Pro Glu Asn Pro
625                 630                 635                 640 
Val Gln Val Ser Ile Asn Gln Leu Thr Ala Ala Ile Tyr Asp Leu Leu
                645                 650                 655     
Arg Leu His Ala Asn Ser Gly Arg Ser Pro Thr Asp Cys Ala Gln Ser
            660                 665                 670         
Ser Lys Ser Val Lys Glu Ala Trp Thr Thr Thr Glu Gln Leu Gln Phe
        675                 680                 685             
Thr Ile Phe Ala Ala His Gly Ile Ser Ser Asn Trp Val Ser Asn Tyr
    690                 695                 700                 
Glu Lys Tyr Tyr Leu Ile Cys Ser Leu Ser His Asn Gly Lys Asp Leu
705                 710                 715                 720 
Phe Lys Pro Ile Gln Ser Lys Lys Val Gly Thr Tyr Lys Asn Phe Phe
                725                 730                 735     
Tyr Leu Ile Lys Trp Asp Glu Leu Ile Ile Phe Pro Ile Gln Ile Ser
            740                 745                 750         
Gln Leu Pro Leu Glu Ser Val Leu His Leu Thr Leu Phe Gly Ile Leu
        755                 760                 765             
Asn Gln Ser Ser Gly Ser Ser Pro Asp Ser Asn Lys Gln Arg Lys Gly
    770                 775                 780                 
Pro Glu Ala Leu Gly Lys Val Ser Leu Pro Leu Cys Asp Phe Arg Arg
785                 790                 795                 800 
Phe Leu Thr Cys Gly Thr Lys Leu Leu Tyr Leu Trp Thr Ser Ser His
                805                 810                 815     
Thr Asn Ser Val Pro Gly Thr Val Thr Lys Lys Gly Tyr Val Met Glu
            820                 825                 830         
Arg Ile Val Leu Gln Val Asp Phe Pro Ser Pro Ala Phe Asp Ile Ile
        835                 840                 845             
Tyr Thr Thr Pro Gln Val Asp Arg Ser Ile Ile Gln Gln His Asn Leu
    850                 855                 860                 
Glu Thr Leu Glu Asn Asp Ile Lys Gly Lys Leu Leu Asp Ile Leu His
865                 870                 875                 880 
Lys Asp Ser Ser Leu Gly Leu Ser Lys Glu Asp Lys Ala Phe Leu Trp
                885                 890                 895     
Glu Lys Arg Tyr Tyr Cys Phe Lys His Pro Asn Cys Leu Pro Lys Ile
            900                 905                 910         
Leu Ala Ser Ala Pro Asn Trp Lys Trp Gly Asn Leu Ala Lys Thr Tyr
        915                 920                 925             
Ser Leu Leu His Gln Trp Pro Ala Leu Tyr Pro Leu Ile Ala Leu Glu
    930                 935                 940                 
Leu Leu Asp Ser Lys Phe Ala Asp Gln Glu Val Arg Ser Leu Ala Val
945                 950                 955                 960 
Thr Trp Ile Glu Ala Ile Ser Asp Asp Glu Leu Thr Asp Leu Leu Pro
                965                 970                 975     
Gln Phe Val Gln Ala Leu Lys Tyr Glu Ile Tyr Leu Asn Ser Ser Leu
            980                 985                 990         
Val Gln Phe Leu Leu Ser Arg Ala Leu Gly Asn Ile Gln Ile Ala His
        995                 1000                1005            
Asn Leu Tyr Trp Leu Leu Lys Asp Ala Leu His Asp Val Gln Phe Ser
    1010                1015                1020                
Thr Arg Tyr Glu His Val Leu Gly Ala Leu Leu Ser Val Gly Gly Lys
1025                1030                1035                1040
Arg Leu Arg Glu Glu Leu Leu Lys Gln Thr Lys Leu Val Gln Leu Leu
                1045                1050                1055    
Gly Gly Val Ala Glu Lys Val Arg Gln Ala Ser Gly Ser Ala Arg Gln
            1060                1065                1070        
Val Val Leu Gln Arg Ser Met Glu Arg Val Gln Ser Phe Phe Gln Lys
        1075                1080                1085            
Asn Lys Cys Arg Leu Pro Leu Lys Pro Ser Leu Val Ala Lys Glu Leu
    1090                1095                1100                
Asn Ile Lys Ser Cys Ser Phe Phe Ser Ser Asn Ala Val Pro Leu Lys
1105                1110                1115                1120
Val Thr Met Val Asn Ala Asp Pro Leu Gly Glu Glu Ile Asn Val Met
                1125                1130                1135    
Phe Lys Val Gly Glu Asp Leu Arg Gln Asp Met Leu Ala Leu Gln Met
            1140                1145                1150        
Ile Lys Ile Met Asp Lys Ile Trp Leu Lys Glu Gly Leu Asp Leu Arg
        1155                1160                1165            
Met Val Ile Phe Lys Cys Leu Ser Thr Gly Arg Asp Arg Gly Met Val
    1170                1175                1180                
Glu Leu Val Pro Ala Ser Asp Thr Leu Arg Lys Ile Gln Val Glu Tyr
1185                1190                1195                1200
Gly Val Thr Gly Ser Phe Lys Asp Lys Pro Leu Ala Glu Trp Leu Arg
                1205                1210                1215    
Lys Tyr Asn Pro Ser Glu Glu Glu Tyr Glu Lys Ala Ser Glu Asn Phe
            1220                1225                1230        
Ile Tyr Ser Cys Ala Gly Cys Cys Val Ala Thr Tyr Val Leu Gly Ile
        1235                1240                1245            
Cys Asp Arg His Asn Asp Asn Ile Met Leu Arg Ser Thr Gly His Met
    1250                1255                1260                
Phe His Ile Asp Phe Gly Lys Phe Leu Gly His Ala Gln Met Phe Gly
1265                1270                1275                1280
Ser Phe Lys Arg Asp Arg Ala Pro Phe Val Leu Thr Ser Asp Met Ala
                1285                1290                1295    
Tyr Val Ile Asn Gly Gly Glu Lys Pro Thr Ile Arg Phe Gln Leu Phe
            1300                1305                1310        
Val Asp Leu Cys Cys Gln Ala Tyr Asn Leu Ile Arg Lys Gln Thr Asn
        1315                1320                1325            
Leu Phe Leu Asn Leu Leu Ser Leu Met Ile Pro Ser Gly Leu Pro Glu
    1330                1335                1340                
Leu Thr Ser Ile Gln Asp Leu Lys Tyr Val Arg Asp Ala Leu Gln Pro
1345                1350                1355                1360
Gln Thr Thr Asp Ala Glu Ala Thr Ile Phe Phe Thr Arg Leu Ile Glu
                1365                1370                1375    
Ser Ser Leu Gly Ser Ile Ala Thr Lys Phe Asn Phe Phe Ile His Asn
            1380                1385                1390        
Leu Ala Gln Leu Arg Phe Ser Gly Leu Pro Ser Asn Asp Glu Pro Ile
        1395                1400                1405            
Leu Ser Phe Ser Pro Lys Thr Tyr Ser Phe Arg Gln Asp Gly Arg Ile
    1410                1415                1420                
Lys Glu Val Ser Val Phe Thr Tyr His Lys Lys Tyr Asn Pro Asp Lys
1425                1430                1435                1440
His Tyr Ile Tyr Val Val Arg Ile Leu Trp Glu Gly Gln Ile Glu Pro
                1445                1450                1455    
Ser Phe Val Phe Arg Thr Phe Val Glu Phe Gln Glu Leu His Asn Lys
            1460                1465                1470        
Leu Ser Ile Ile Phe Pro Leu Trp Lys Leu Pro Gly Phe Pro Asn Arg
        1475                1480                1485            
Met Val Leu Gly Arg Thr His Ile Lys Asp Val Ala Ala Lys Arg Lys
    1490                1495                1500                
Ile Glu Leu Asn Ser Tyr Leu Gln Ser Leu Met Asn Ala Ser Thr Asp
1505                1510                1515                1520
Val Ala Glu Cys Asp Leu Val Cys Thr Phe Phe His Pro Leu Leu Arg
                1525                1530                1535    
Asp Glu Lys Ala Glu Gly Ile Ala Arg Ser Ala Asp Ala Gly Ser Phe
            1540                1545                1550        
Ser Pro Thr Pro Gly Gln Ile Gly Gly Ala Val Lys Leu Ser Ile Ser
        1555                1560                1565            
Tyr Arg Asn Gly Thr Leu Phe Ile Met Val Met His Ile Lys Asp Leu
    1570                1575                1580                
Val Thr Glu Asp Gly Ala Asp Pro Asn Pro Tyr Val Lys Thr Tyr Leu
1585                1590                1595                1600
Leu Pro Asp Asn His Lys Thr Ser Lys Arg Lys Thr Lys Ile Ser Arg
                1605                1610                1615    
Lys Thr Arg Asn Pro Thr Phe Asn Glu Met Leu Val Tyr Ser Gly Tyr
            1620                1625                1630        
Ser Lys Glu Thr Leu Arg Gln Arg Glu Leu Gln Leu Ser Val Leu Ser
        1635                1640                1645            
Ala Glu Ser Leu Arg Glu Asn Phe Phe Leu Gly Gly Val Thr Leu Pro
    1650                1655                1660                
Leu Lys Asp Phe Asn Leu Ser Lys Glu Thr Val Lys Trp Tyr Gln Leu
1665                1670                1675                1680
Thr Ala Ala Thr Tyr Leu
                1685    


<210> 7922
<211> 389
<212> PRT
<213> Homo sapiens

<400> 7922
Met Ser Glu Ile Arg Phe Thr Asn Leu Thr Trp Asp Gln Val Ile Thr
 1               5                  10                  15      
Leu Asp Gln Val Leu Asp Glu Val Ile Pro Ile His Gly Lys Gly Asn
            20                  25                  30          
Phe Pro Thr Met Glu Val Lys Pro Lys Asp Ile Ile His Val Val Lys
        35                  40                  45              
Asp Gln Leu Ile Gly Gln Gly Ile Ile Val Lys Asp Ala Arg Leu Asn
    50                  55                  60                  
Gly Ser Val Ala Ser Tyr Ile Leu Ala Ser His Asn Gly Ile Ser Tyr
65                  70                  75                  80  
Lys Asp Leu Asp Val Ile Phe Gly Val Glu Leu Pro Gly Asn Glu Glu
                85                  90                  95      
Phe Gln Val Val Lys Asp Ala Val Leu Asp Cys Leu Leu Asp Phe Leu
            100                 105                 110         
Pro Lys Asp Val Lys Lys Glu Lys Leu Ser Pro Asp Ile Met Lys Asp
        115                 120                 125             
Ala Tyr Val Gln Lys Leu Val Lys Val Cys Asn Gly His Asp Cys Trp
    130                 135                 140                 
Ser Leu Ile Ser Leu Ser Asn Asn Thr Gly Lys Asn Leu Glu Leu Lys
145                 150                 155                 160 
Phe Val Ser Ser Leu Arg Arg Gln Phe Glu Phe Ser Val Asp Ser Phe
                165                 170                 175     
Gln Ile Val Leu Asp Pro Met Leu Asp Phe Tyr Ser Asp Lys Asn Ala
            180                 185                 190         
Lys Leu Thr Lys Glu Ser Tyr Pro Val Val Val Ala Glu Ser Met Tyr
        195                 200                 205             
Gly Asp Phe Gln Glu Ala Met Thr His Leu Gln His Lys Leu Ile Cys
    210                 215                 220                 
Thr Arg Lys Pro Glu Glu Ile Arg Gly Gly Gly Leu Leu Lys Tyr Cys
225                 230                 235                 240 
Ser Leu Leu Val His Gly Phe Lys Pro Ala Cys Met Ser Glu Ile Lys
                245                 250                 255     
Asn Leu Glu Arg Tyr Met Cys Ser Arg Phe Phe Ile Asp Phe Pro His
            260                 265                 270         
Ile Glu Glu Gln Gln Lys Lys Ile Glu Ser Tyr Leu His Asn His Phe
        275                 280                 285             
Ile Gly Glu Gly Met Thr Lys Tyr Asp Tyr Leu Met Thr Leu His Gly
    290                 295                 300                 
Val Val Asn Glu Ser Thr Val Cys Leu Met Ser Tyr Glu Arg Arg Gln
305                 310                 315                 320 
Ile Leu His Leu Ile Thr Met Met Ala Leu Lys Val Leu Gly Glu Leu
                325                 330                 335     
Asn Ile Leu Pro Asn Thr Gln Lys Val Thr Cys Phe Tyr Gln Pro Ala
            340                 345                 350         
Pro Tyr Phe Ala Ala Glu Ala Arg Tyr Pro Ile Tyr Val Ile Pro Glu
        355                 360                 365             
Pro Pro Pro Val Ser Phe Gln Pro Tyr His Pro Leu His Phe Arg Gly
    370                 375                 380                 
Ser Asn Gly Met Ser
385                 


<210> 7923
<211> 675
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 610
<223> Xaa = Any Amino Acid

<400> 7923
Met Gly Thr Lys Gly His Ala Tyr Leu Ala Leu Gly His Gln Gly Gly
 1               5                  10                  15      
Leu Gln Asn Glu Val Leu Gly Ser Pro Leu Lys Ala Val Leu Ile Gln
            20                  25                  30          
Cys Arg Arg Gly Thr Gly Thr Leu Ser Arg His Gln Gly Ala Asp Lys
        35                  40                  45              
Gly Ala Asp Glu Gly Ser Gln Cys Asp Glu Gly Ala Asp Glu Gly Ser
    50                  55                  60                  
Gln Cys Asp Glu Gly Ala Asp Glu Gly Ser Gln Trp Asp Glu Gly Ala
65                  70                  75                  80  
Gly Glu Gly Ser Gln His Asp Lys Gly Thr Gly Glu Gly Ser Gln Arg
                85                  90                  95      
Ala Arg Ala Leu Val Lys Ala Ala Ser Ala Gly Val Pro Gly Val Gln
            100                 105                 110         
Val Thr Gly Lys Val Gly Glu Arg Thr Thr Gly Gly Ala Ala Ser Lys
        115                 120                 125             
Met Gly Leu Gln Ala Leu Gly Glu Leu Asn Ser Gly Gly Ser Cys Ala
    130                 135                 140                 
Ser Pro Arg Gly Arg Ser Glu Trp Asp Gly Trp His Ala Gly His Gln
145                 150                 155                 160 
Gly Gly Leu Gly Ala Ser Ala Gly Met Glu Gly Glu Gln Thr Met Lys
                165                 170                 175     
Gly Leu Gln Pro Thr Leu Lys Arg Ala Cys Ile Leu Lys Gly Phe Met
            180                 185                 190         
Lys Glu Lys Lys Trp Cys Pro Thr Cys Leu Ser Arg Lys Val Asp Glu
        195                 200                 205             
Trp Ile Arg Ser Leu His Tyr Asn Cys Val Lys Trp Lys Tyr Glu Gln
    210                 215                 220                 
Leu Asn Ser Ile Gln Lys Leu Ser Ser Val His Ser Pro Ser Pro Ala
225                 230                 235                 240 
Ala Glu Pro Phe Leu Leu Thr Lys Glu Ser Arg Gly Ala Ala Arg Pro
                245                 250                 255     
Ala Ser Ser Ser Pro Pro Val Val His Ser Trp Gln Glu Pro Gly Ile
            260                 265                 270         
Thr Thr Val Ser Arg Leu Lys Cys Ala Gln Gly Arg Ala Pro Gly Ala
        275                 280                 285             
Leu Pro Pro Gly Glu Glu Asn Pro Ser Glu Val Val Leu Cys Ala Phe
    290                 295                 300                 
Ser Lys Arg Glu Ala Gln Tyr Glu His Ser Leu Arg Pro Leu Lys Glu
305                 310                 315                 320 
Asp Arg Thr Gln Thr Ala Ala Ser Ser Leu Thr Ser Pro Ala Thr Ser
                325                 330                 335     
Leu Arg His His Gly Glu Gly Glu Gly Gln Gly Gln Trp Ile Trp Ser
            340                 345                 350         
Tyr Trp Ala Pro Gly Gln Gln Gly Tyr Phe Asn Ser Gly Lys Val Asp
        355                 360                 365             
Ile Ile Thr Ile Ser Asp Pro Phe Ile Asp Leu Lys Tyr Met Val Tyr
    370                 375                 380                 
Met Phe Leu Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Ile Lys
385                 390                 395                 400 
Ala Glu Asn Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe
                405                 410                 415     
Gln Glu Arg Asp Pro Ser Lys Ile Lys Trp Gly Thr Ala Gly Ala Glu
            420                 425                 430         
Tyr Ile Val Glu Pro Thr Gly Thr Phe Thr Thr Met Glu Lys Thr Gly
        435                 440                 445             
Ala His Leu Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser
    450                 455                 460                 
Ala Asp Ala Ser Val Phe Ile Met Gly Val Asn Asn Glu Lys Tyr Asp
465                 470                 475                 480 
Asn Ser Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu
                485                 490                 495     
Ala Pro Arg Ala Lys Val Leu His Asp Asn Phe Gly Ile Val Lys Gly
            500                 505                 510         
Leu Met Thr Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp
        515                 520                 525             
Gly Pro Ser Arg Lys Leu Trp His Asp Gly Gly Gly Thr Leu Gln Asn
    530                 535                 540                 
Ile Ile Pro Ala Ser Thr Gly Thr Ala Lys Ala Val Gly Lys Val Ile
545                 550                 555                 560 
Pro Glu Leu Asn Gly Lys Leu Thr Gly Met Ala Phe Cys Val Pro Thr
                565                 570                 575     
Ala Asn Val Ser Val Val Asp Leu Ile Tyr His Leu Glu Lys Pro Thr
            580                 585                 590         
Lys Tyr His Gly Ile Lys Lys Val Val Lys Glu Ala Ser Glu Gly Ser
        595                 600                 605             
Leu Xaa Gly Ile Leu Gly Tyr Asn Thr Glu His Gln Val Val Ser Phe
    610                 615                 620                 
Asp Phe Asn Ser Asp Ile His Ser Ser Thr Phe Asp Val Gly Ala Gly
625                 630                 635                 640 
Ile Ala Leu Asn Asn His Cys Val Lys Leu Ile Ser Trp Tyr Glu Asn
                645                 650                 655     
Glu Phe Gly Tyr Ser Asn Arg Val Val Asp Val Met Ala His Lys Ser
            660                 665                 670         
Ser Lys Glu
        675 


<210> 7924
<211> 364
<212> PRT
<213> Homo sapiens

<400> 7924
Asp Gly Cys Gly His Thr Val Leu Gly Pro Glu Ser Gly Thr Leu Thr
 1               5                  10                  15      
Ser Ile Asn Tyr Pro Gln Thr Tyr Pro Asn Ser Thr Val Cys Glu Trp
            20                  25                  30          
Glu Ile Arg Val Lys Met Gly Glu Arg Val Arg Ile Lys Phe Gly Asp
        35                  40                  45              
Phe Asp Ile Glu Asp Ser Asp Ser Cys His Phe Asn Tyr Leu Arg Ile
    50                  55                  60                  
Tyr Asn Gly Ile Gly Val Ser Arg Thr Glu Ile Gly Lys Tyr Cys Gly
65                  70                  75                  80  
Leu Gly Leu Gln Ile Asn His Ser Ile Glu Ser Lys Gly Asn Glu Ile
                85                  90                  95      
Thr Leu Leu Phe Met Ser Gly Ile His Val Ser Gly Arg Gly Phe Leu
            100                 105                 110         
Ala Ser Tyr Ser Val Ile Asp Lys Gln Arg Ser Asn Tyr Leu Phe Gly
        115                 120                 125             
His Cys Ile Gln Phe Phe Trp Asn Leu Ser Ser Val Ser Thr Ala Pro
    130                 135                 140                 
Ala Gly Cys Leu Leu Pro Phe Ala Glu Ile Ser Gly Thr Ile Pro His
145                 150                 155                 160 
Gly Tyr Arg Asp Ser Ser Pro Leu Cys Met Ala Gly Val His Ala Gly
                165                 170                 175     
Val Val Ser Asn Thr Leu Gly Gly Gln Ile Ser Val Val Ile Ser Lys
            180                 185                 190         
Gly Ile Pro Tyr Tyr Glu Ser Ser Leu Ala Asn Asn Val Thr Ser Val
        195                 200                 205             
Val Gly His Leu Ile Leu Gln Val Phe Phe Thr Phe Lys Thr Ser Gly
    210                 215                 220                 
Cys Tyr Gly Thr Leu Gly Met Glu Ser Gly Gly Asp Arg Gly Ser Ser
225                 230                 235                 240 
Asn Asn Ser Ile Thr Val Leu Glu Trp Thr Asp His Thr Gly Gln Glu
                245                 250                 255     
Asn Ser Trp Lys Pro Lys Lys Ser Gln Ala Glu Lys Thr Trp Thr Ala
            260                 265                 270         
Leu Gly Ala Phe Ala Thr Asp Glu Tyr Gln Trp Leu Gln Ile Asp Leu
        275                 280                 285             
Asn Lys Glu Lys Lys Ile Thr Gly Ile Ile Thr Thr Gly Ser Thr Met
    290                 295                 300                 
Val Ser Thr Ile Thr Met Cys Leu Pro Thr Glu Ser Cys Thr Val Met
305                 310                 315                 320 
Met Gly Arg Asn Gly Leu Cys Thr Glu Ser Leu Val Val Glu Gln Asp
                325                 330                 335     
Lys Ile Phe Gln Gly Asn Lys Arg Ile Ile Thr Arg Met Val Arg Asn
            340                 345                 350         
Asn Phe Leu Pro Pro Ile Ile Ala Arg Leu Leu Glu
        355                 360                 


<210> 7925
<211> 534
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 265
<223> Xaa = Any Amino Acid

<400> 7925
Met Val Ile Gly Glu Lys Leu Thr Phe Asn Arg Asn Ser Pro Leu Thr
 1               5                  10                  15      
His Ser Pro Val Pro Leu Phe Leu Ser Leu Phe Pro Leu Ser Ser Trp
            20                  25                  30          
Lys His Thr Gly Tyr Leu Arg Lys Asp Phe Gly Ser Gln His Ser Glu
        35                  40                  45              
Ala Cys Ser Leu Ser Ser Ser Leu Leu Pro Gly Thr Phe Arg Ala Val
    50                  55                  60                  
Ser Val Phe Gln Thr Tyr His His Val Arg Thr Ser Asn Leu Thr Ser
65                  70                  75                  80  
Gly Pro Glu Met Glu Met Gly His Ser Leu Lys Thr Val Thr Val Ser
                85                  90                  95      
Tyr Arg Lys Val Lys Ser Leu Thr Val Pro Ser Thr Val Pro Pro Leu
            100                 105                 110         
Asn Gln Gly Thr Ile Lys Tyr Ala Leu Ile Ile Val Met Met Thr Ile
        115                 120                 125             
Met Thr Ala Thr Asp Ile Gln Leu Leu Asn Gln Thr Met Glu Asn Thr
    130                 135                 140                 
Arg Gln Gly Arg Arg Gly Pro Asp Pro Gln Pro Pro Ser His Ser Gly
145                 150                 155                 160 
Ser Leu Arg Ala Arg Asp Phe Glu Ser Glu Glu Leu Leu Ala Pro Arg
                165                 170                 175     
Ala Ala Gly Gln Asp Leu Val Ser Leu Lys Arg Gly Pro Asp Asn Gln
            180                 185                 190         
His Glu Asn Pro Cys Phe Leu Phe Leu Lys Cys Asn Pro Asp Gly Gly
        195                 200                 205             
Glu Glu Ile Ala Ser Ile Gly Ile Leu Ser Ser Ala Arg Asn Thr Glu
    210                 215                 220                 
Val Tyr Pro Gly Glu Glu Tyr Cys Gly Thr Ser Arg Gly Lys Asn Val
225                 230                 235                 240 
Tyr Thr Val Leu Asp Tyr Arg Thr Val Arg Thr Trp Glu Ile Glu Asn
                245                 250                 255     
Pro Lys Lys Gln Lys Lys Cys Val Xaa Thr Thr Asp Asp Ala Glu Gln
            260                 265                 270         
Lys Asn Val Ile Pro Thr Thr Cys Thr Tyr Ser Arg Asp Gly Asn Leu
        275                 280                 285             
Ile Ala Ala Ala Cys Gln Asn Gly Ser Met Gln Ile Trp Asp Arg Tyr
    290                 295                 300                 
Leu Thr Val His Pro Lys Phe Asn Tyr Lys Gln Pro His Tyr Leu Gly
305                 310                 315                 320 
Thr Asp Thr Ser Cys Val Thr Phe Ser Tyr Asp Gly Asn Val Leu Ala
                325                 330                 335     
Ser Arg Gly Gly Asp Asp Ser Leu Lys Leu Trp Asp Ile Arg Gln Phe
            340                 345                 350         
Asn Lys His Phe Phe Gln Pro Pro Gly Leu Pro Thr Met Phe Pro Met
        355                 360                 365             
Ile Asp Cys Cys Phe Ser Pro Asp Asp Lys Leu Ile Val Thr Gly Thr
    370                 375                 380                 
Ser Val Gln Arg Gly Cys Gly Ser Gly Lys Leu Val Cys Leu Glu Leu
385                 390                 395                 400 
Tyr Tyr Asn Pro Asn Lys Ser Gln Arg Gly Ala Lys Leu Tyr Val Val
                405                 410                 415     
Lys Thr Arg Arg Lys Gly Thr Arg Gln Ser His Gly Thr Ala Ala Arg
            420                 425                 430         
Ser Leu Gly Trp Trp Glu Ala Lys Gln Ala Glu Thr Leu Thr Gln Asp
        435                 440                 445             
Tyr Ile Ile Ala Pro His Val Leu Pro Met Phe Cys Glu Pro His Glu
    450                 455                 460                 
Arg Ser Thr Arg Lys Gln Leu Glu Lys Asp Arg Leu Asp Pro Leu Lys
465                 470                 475                 480 
Leu His Lys Pro Glu Pro Pro Val Ala Asp Pro Gly Cys Glu Asp Asn
                485                 490                 495     
Pro Tyr Trp Val Ser Pro Thr His Ser Lys Thr Gln Pro Arg Ile Met
            500                 505                 510         
Phe Gly Gln Val Glu Ser Asp Asp Glu Glu Ala Lys Asn Glu Pro Glu
        515                 520                 525             
Trp Lys Lys Cys Lys Ile
    530                 


<210> 7926
<211> 522
<212> PRT
<213> Homo sapiens

<400> 7926
Met Ser Ile Thr Ser Asp Glu Val Asn Phe Leu Val Tyr Arg Tyr Leu
 1               5                  10                  15      
Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe Gly Ile Glu Ser
            20                  25                  30          
His Ile Ser Gln Ser Asn Ile Asn Gly Thr Leu Val Pro Pro Ser Ala
        35                  40                  45              
Leu Ile Ser Ile Leu Gln Lys Gly Leu Gln Tyr Val Glu Ala Glu Ile
    50                  55                  60                  
Ser Ile Asn Lys Asp Gly Thr Val Phe Asp Ser Arg Pro Ile Glu Ser
65                  70                  75                  80  
Leu Ser Leu Ile Val Ala Val Ile Pro Asp Val Val Gln Met Arg Gln
                85                  90                  95      
Gln Ala Phe Gly Glu Lys Leu Thr Gln Gln Gln Ala Ser Ala Ala Ala
            100                 105                 110         
Thr Glu Ala Ser Ala Met Ala Lys Ala Ala Thr Met Thr Pro Ala Ala
        115                 120                 125             
Ile Ser Gln Gln Asn Pro Pro Lys Asn Arg Glu Ala Thr Val Asn Gly
    130                 135                 140                 
Glu Glu Asn Gly Ala His Glu Ile Asn Asn His Ser Lys Pro Met Glu
145                 150                 155                 160 
Ile Asp Gly Asp Val Glu Ile Pro Pro Asn Lys Ala Thr Val Leu Arg
                165                 170                 175     
Gly His Glu Ser Glu Val Phe Ile Cys Ala Trp Asn Pro Val Ser Asp
            180                 185                 190         
Leu Leu Ala Ser Gly Ser Gly Asp Ser Thr Ala Arg Ile Trp Asn Leu
        195                 200                 205             
Asn Glu Asn Ser Asn Gly Gly Ser Thr Gln Leu Val Leu Arg His Cys
    210                 215                 220                 
Ile Arg Glu Gly Gly His Asp Val Pro Ser Asn Lys Asp Val Thr Ser
225                 230                 235                 240 
Leu Asp Trp Asn Ser Asp Gly Thr Leu Leu Ala Met Gly Ser Tyr Asp
                245                 250                 255     
Gly Phe Ala Arg Ile Trp Thr Glu Asn Gly Asn Leu Ala Ser Thr Leu
            260                 265                 270         
Gly Gln His Lys Gly Pro Ile Phe Ala Leu Lys Trp Asn Lys Lys Gly
        275                 280                 285             
Asn Tyr Val Leu Ser Ala Gly Val Asp Lys Thr Thr Ile Ile Trp Asp
    290                 295                 300                 
Ala His Thr Gly Glu Ala Lys Gln Gln Phe Pro Phe His Ser Ala Pro
305                 310                 315                 320 
Ala Leu Asp Val Asp Trp Gln Asn Asn Met Thr Phe Ala Ser Cys Ser
                325                 330                 335     
Thr Asp Met Cys Ile His Val Cys Arg Leu Gly Cys Asp His Pro Val
            340                 345                 350         
Lys Thr Phe Gln Gly His Thr Asn Glu Val Asn Ala Ile Lys Trp Asp
        355                 360                 365             
Pro Ser Gly Met Leu Leu Ala Ser Cys Ser Asp Asp Met Thr Leu Lys
    370                 375                 380                 
Ile Trp Ser Met Lys Gln Asp Ala Cys Val His Asp Leu Gln Ala His
385                 390                 395                 400 
Ser Lys Glu Ile Tyr Thr Ile Lys Trp Ser Pro Thr Gly Pro Ala Thr
                405                 410                 415     
Ser Asn Pro Asn Ser Ser Ile Met Leu Ala Ser Ala Ser Phe Asp Ser
            420                 425                 430         
Thr Val Arg Leu Trp Asp Val Glu Gln Gly Val Cys Thr His Thr Leu
        435                 440                 445             
Met Lys His Gln Glu Pro Val Tyr Ser Val Ala Phe Ser Pro Asp Gly
    450                 455                 460                 
Lys Tyr Leu Ala Ser Gly Ser Phe Asp Lys Tyr Val His Ile Trp Asn
465                 470                 475                 480 
Thr Gln Ser Gly Ser Leu Val His Ser Tyr Gln Gly Thr Gly Gly Ile
                485                 490                 495     
Phe Glu Val Cys Trp Asn Ala Arg Gly Asp Lys Val Gly Ala Ser Ala
            500                 505                 510         
Ser Asp Gly Ser Val Cys Val Leu Asp Leu
        515                 520         


<210> 7927
<211> 653
<212> PRT
<213> Homo sapiens

<400> 7927
Met Pro Ala Ser Arg Leu Arg Asp Arg Ala Ala Ser Ser Ala Ser Gly
 1               5                  10                  15      
Ser Thr Cys Gly Ser Met Ser Gln Thr His Pro Val Leu Glu Ser Gly
            20                  25                  30          
Leu Leu Ala Ser Ala Gly Cys Ser Ala Pro Arg Gly Pro Arg Lys Gly
        35                  40                  45              
Gly Pro Ala Pro Val Asp Arg Lys Ala Lys Ala Ser Ala Met Pro Asp
    50                  55                  60                  
Ser Pro Ala Glu Val Lys Thr Gln Pro Arg Ser Thr Pro Pro Ser Met
65                  70                  75                  80  
Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Thr Arg Pro Pro Ser
                85                  90                  95      
Phe Thr Pro His Thr His Arg Glu Asp Gly Pro Ala Thr Leu Pro His
            100                 105                 110         
Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met Val Cys Leu Leu Met
        115                 120                 125             
Asn Gly Ser Ser His Ser Pro Thr Ala Ile Asn Gly Ala Pro Cys Thr
    130                 135                 140                 
Pro Asn Gly Phe Ser Asn Gly Pro Ala Thr Ser Ser Thr Ala Ser Leu
145                 150                 155                 160 
Ser Thr Gln His Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys
                165                 170                 175     
Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Ser Asp Ile Ser
            180                 185                 190         
Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn
        195                 200                 205             
Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr
    210                 215                 220                 
Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu
225                 230                 235                 240 
Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln
                245                 250                 255     
Thr Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala
            260                 265                 270         
Ser Ala Ser Ser Pro Ile Asp Ser Ser Glu Leu Leu Leu Glu Val Asn
        275                 280                 285             
Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly Ser
    290                 295                 300                 
Glu Arg Asp Pro Leu His Pro Glu His Leu Ser Lys Arg Pro Cys Thr
305                 310                 315                 320 
Leu Asn Pro Ala Gln Arg Tyr Ser Pro Ser Asn Gly Pro Pro Gln Pro
                325                 330                 335     
Thr Pro Pro Pro His Tyr Arg Leu Glu Asp Ile Ala Met Ala His His
            340                 345                 350         
Phe Arg Asp Ala Tyr Arg His Pro Asp Pro Arg Glu Leu Arg Glu Arg
        355                 360                 365             
His Arg Pro Leu Val Val Pro Gly Ser Arg Gln Glu Glu Val Ile Asp
    370                 375                 380                 
His Lys Leu Thr Glu Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asn
385                 390                 395                 400 
Asn Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys Thr Arg Arg Ser
                405                 410                 415     
Leu Thr Val Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn
            420                 425                 430         
His Trp Ala Arg Arg Tyr Ser Asp Ala Glu Asp Thr Lys Lys Gly Pro
        435                 440                 445             
Ala Pro Ala Ala Ala Arg Pro Arg Ser Ser Ser Ala Gly Pro Glu Gly
    450                 455                 460                 
Pro Gln Leu Asp Val Pro Arg Glu Phe Leu Pro Arg Thr Leu Thr Gly
465                 470                 475                 480 
Tyr Val Pro Glu Asp Ile Trp Arg Lys Ala Glu Glu Ala Val Asn Glu
                485                 490                 495     
Val Lys Arg Gln Ala Met Ser Glu Leu Gln Lys Ala Val Ser Asp Ala
            500                 505                 510         
Glu Arg Lys Ala His Glu Leu Ile Thr Thr Glu Arg Ala Lys Met Glu
        515                 520                 525             
Arg Ala Leu Ala Glu Ala Lys Arg Gln Ala Ser Glu Asp Ala Leu Thr
    530                 535                 540                 
Val Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly
545                 550                 555                 560 
Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Ala Ala Arg Tyr Cys
                565                 570                 575     
Gly Ser Phe Cys Gln His Arg Asp Trp Glu Lys His His His Val Cys
            580                 585                 590         
Gly Gln Ser Leu Gln Gly Pro Thr Ala Val Val Ala Asp Pro Val Pro
        595                 600                 605             
Gly Pro Pro Glu Ala Ala His Ser Leu Gly Pro Ser Leu Pro Val Gly
    610                 615                 620                 
Ala Ala Ser Pro Ser Glu Ala Gly Ser Ala Gly Pro Ser Arg Pro Gly
625                 630                 635                 640 
Ser Pro Ser Pro Pro Gly Pro Leu Asp Thr Val Pro Arg
                645                 650             


<210> 7928
<211> 545
<212> PRT
<213> Homo sapiens

<400> 7928
Met Pro Ala Ser Arg Leu Arg Asp Arg Ala Ala Ser Ser Ala Ser Gly
 1               5                  10                  15      
Ser Thr Cys Gly Ser Met Ser Gln Thr His Pro Val Leu Glu Ser Gly
            20                  25                  30          
Leu Leu Ala Ser Ala Gly Cys Ser Ala Pro Arg Gly Pro Arg Lys Gly
        35                  40                  45              
Gly Pro Ala Pro Val Asp Arg Lys Ala Lys Ala Ser Ala Met Pro Asp
    50                  55                  60                  
Ser Pro Ala Glu Val Lys Thr Gln Pro Arg Ser Thr Pro Pro Ser Met
65                  70                  75                  80  
Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Thr Arg Pro Pro Ser
                85                  90                  95      
Phe Thr Pro His Thr His Arg Glu Asp Gly Pro Ala Thr Leu Pro His
            100                 105                 110         
Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met Val Cys Leu Leu Met
        115                 120                 125             
Asn Gly Ser Ser His Ser Pro Thr Ala Ile Asn Gly Ala Pro Cys Thr
    130                 135                 140                 
Pro Asn Gly Phe Ser Asn Gly Pro Ala Thr Ser Ser Thr Ala Ser Leu
145                 150                 155                 160 
Ser Thr Gln His Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys
                165                 170                 175     
Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Ser Asp Ile Ser
            180                 185                 190         
Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn
        195                 200                 205             
Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr
    210                 215                 220                 
Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu
225                 230                 235                 240 
Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln
                245                 250                 255     
Thr Pro Ala Gln Tyr Leu Ala Gln Leu Val Pro Gly Ser Arg Gln Glu
            260                 265                 270         
Glu Val Ile Asp His Lys Leu Thr Glu Arg Glu Trp Ala Glu Glu Trp
        275                 280                 285             
Lys His Leu Asn Asn Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys
    290                 295                 300                 
Thr Arg Arg Ser Leu Thr Val Leu Arg Arg Cys Gln Glu Ala Asp Arg
305                 310                 315                 320 
Gly Glu Leu Asn His Trp Ala Arg Arg Tyr Ser Asp Ala Glu Asp Thr
                325                 330                 335     
Lys Lys Gly Pro Ala Pro Ala Ala Ala Arg Pro Arg Ser Ser Ser Ala
            340                 345                 350         
Gly Pro Glu Gly Pro Gln Leu Asp Val Pro Arg Glu Phe Leu Pro Arg
        355                 360                 365             
Thr Leu Thr Gly Tyr Val Pro Glu Asp Ile Trp Arg Lys Ala Glu Glu
    370                 375                 380                 
Ala Val Asn Glu Val Lys Arg Gln Ala Met Ser Glu Leu Gln Lys Ala
385                 390                 395                 400 
Val Ser Asp Ala Glu Arg Lys Ala His Glu Leu Ile Thr Thr Glu Arg
                405                 410                 415     
Ala Lys Met Glu Arg Ala Leu Ala Glu Ala Lys Arg Gln Ala Ser Glu
            420                 425                 430         
Asp Ala Leu Thr Val Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys
        435                 440                 445             
Trp Asn Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Ala
    450                 455                 460                 
Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Arg Asp Trp Glu Lys His
465                 470                 475                 480 
His His Val Cys Gly Gln Ser Leu Gln Gly Pro Thr Ala Val Val Ala
                485                 490                 495     
Asp Pro Val Pro Gly Pro Pro Glu Ala Ala His Ser Leu Gly Pro Ser
            500                 505                 510         
Leu Pro Val Gly Ala Ala Ser Pro Ser Glu Ala Gly Ser Ala Gly Pro
        515                 520                 525             
Ser Arg Pro Gly Ser Pro Ser Pro Pro Gly Pro Leu Asp Thr Val Pro
    530                 535                 540                 
Arg
545 


<210> 7929
<211> 1278
<212> PRT
<213> Homo sapiens

<400> 7929
Met Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly
 1               5                  10                  15      
Leu Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr
            20                  25                  30          
Ile Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg
        35                  40                  45              
Asp Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met
    50                  55                  60                  
Asp Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn
65                  70                  75                  80  
His Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His
                85                  90                  95      
Cys Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly
            100                 105                 110         
Ser Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu
        115                 120                 125             
Asp Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu
    130                 135                 140                 
Gln His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn
145                 150                 155                 160 
Asn Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly
                165                 170                 175     
Val Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val
            180                 185                 190         
Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln
        195                 200                 205             
Tyr Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile
    210                 215                 220                 
Thr Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His
225                 230                 235                 240 
Pro Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu
                245                 250                 255     
Leu His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln
            260                 265                 270         
Cys Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu
        275                 280                 285             
Asp His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln
    290                 295                 300                 
Lys Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val
305                 310                 315                 320 
Ala Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val
                325                 330                 335     
Glu Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu
            340                 345                 350         
Val Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala
        355                 360                 365             
Asp Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn
    370                 375                 380                 
Pro Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr
385                 390                 395                 400 
His Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala
                405                 410                 415     
Asp Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile
            420                 425                 430         
Val Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu
        435                 440                 445             
Ile Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu
    450                 455                 460                 
Arg Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn
465                 470                 475                 480 
Ser Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu
                485                 490                 495     
Glu Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser
            500                 505                 510         
Glu Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu
        515                 520                 525             
Lys Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln
    530                 535                 540                 
Lys Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr
545                 550                 555                 560 
Ile Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu
                565                 570                 575     
Ser Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile
            580                 585                 590         
Gly Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly
        595                 600                 605             
Ile Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His
    610                 615                 620                 
Gln Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala
625                 630                 635                 640 
Ala Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr
                645                 650                 655     
Ser His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr
            660                 665                 670         
Val Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr
        675                 680                 685             
Gly Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln
    690                 695                 700                 
Pro Asp Glu Asn Ile Cys Ser Ala Gly Gly Gly Met Asn Val Gly Ile
705                 710                 715                 720 
Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn Ser Phe Glu Gln
                725                 730                 735     
Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr Tyr Phe Asn Gln
            740                 745                 750         
His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn Glu Gly Ile Asp
        755                 760                 765             
Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu Leu Asp Met Phe
    770                 775                 780                 
Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp Glu Glu Ser Arg
785                 790                 795                 800 
Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys Phe Glu Asp Asn
                805                 810                 815     
Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val Glu Leu Cys Phe
            820                 825                 830         
Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp Ala Ser Gly Val
        835                 840                 845             
Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val Val Val Val Leu
    850                 855                 860                 
Arg Thr Ser Glu Asn Met Leu Leu Gln Gln Leu Phe Ser Ile Pro Leu
865                 870                 875                 880 
Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg Ile Thr Val Ala
                885                 890                 895     
Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys Ala Lys Val Asp
            900                 905                 910         
Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr Asn Met Lys Arg
        915                 920                 925             
Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser
    930                 935                 940                 
Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn
945                 950                 955                 960 
Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg Val Leu Ala Gln
                965                 970                 975     
Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile Arg Arg Gln Gly
            980                 985                 990         
Tyr Ser His Arg Ile Leu Phe Glu Glu Phe Val Lys Arg Tyr Tyr Tyr
        995                 1000                1005            
Leu Ala Phe Thr Ala His Gln Thr Pro Leu Ala Ser Lys Glu Ser Cys
    1010                1015                1020                
Val Ala Ile Leu Glu Lys Ser Arg Leu Asp His Trp Val Leu Gly Lys
1025                1030                1035                1040
Thr Lys Val Phe Leu Lys Tyr Tyr His Val Glu Gln Leu Asn Leu Leu
                1045                1050                1055    
Leu Arg Glu Val Ile Gly Arg Val Val Val Leu Gln Ala Tyr Thr Lys
            1060                1065                1070        
Gly Trp Leu Gly Ala Arg Arg Tyr Lys Lys Val Arg Glu Lys Arg Glu
        1075                1080                1085            
Lys Gly Ala Ile Ala Ile Gln Ser Ala Trp Arg Gly Tyr Asp Ala Arg
    1090                1095                1100                
Arg Lys Phe Lys Lys Ile Ser Asn Arg Arg Asn Glu Ser Ala Ala His
1105                1110                1115                1120
Asn Gln Ala Gly Asp Thr Ser Asn Gln Ser Ser Gly Pro His Ser Pro
                1125                1130                1135    
Val Ala Ala Gly Thr Arg Gly Ser Ala Glu Val Gln Asp Cys Ser Glu
            1140                1145                1150        
Pro Gly Asp His Lys Val Leu Arg Gly Ser Val His Arg Arg Ser His
        1155                1160                1165            
Ser Gln Ala Glu Ser Asn Asn Gly Arg Thr Gln Thr Ser Ser Asn Ser
    1170                1175                1180                
Pro Ala Val Thr Glu Lys Asn Gly His Ser Gln Ala Gln Ser Ser Pro
1185                1190                1195                1200
Lys Gly Cys Asp Ile Phe Ala Gly His Ala Asn Lys His Ser Val Ser
                1205                1210                1215    
Gly Thr Asp Leu Leu Ser Ser Arg Ile Cys His Pro Ala Pro Asp Gln
            1220                1225                1230        
Gln Gly Leu Ser Leu Trp Gly Ala Pro Gln Lys Pro Ala Phe Pro His
        1235                1240                1245            
Tyr Gly Cys Asn Phe Tyr Gly Phe Arg Lys Trp Ser Cys Thr Glu Ala
    1250                1255                1260                
Ser Asn Thr Ser Pro Thr Met Ser Ala Ala Gln Asn Ala Glu
1265                1270                1275            


<210> 7930
<211> 1865
<212> PRT
<213> Homo sapiens

<400> 7930
Met Thr Arg Trp Val Pro Thr Lys Arg Glu Glu Lys Tyr Gly Val Ala
 1               5                  10                  15      
Phe Tyr Asn Tyr Asp Ala Arg Gly Ala Asp Glu Leu Ser Leu Gln Ile
            20                  25                  30          
Gly Asp Thr Val His Ile Leu Glu Thr Tyr Glu Gly Trp Tyr Arg Gly
        35                  40                  45              
Tyr Thr Leu Arg Lys Lys Ser Lys Lys Gly Ile Phe Pro Ala Ser Tyr
    50                  55                  60                  
Ile His Leu Lys Glu Ala Ile Val Glu Gly Lys Gly Gln His Glu Thr
65                  70                  75                  80  
Val Ile Pro Gly Asp Leu Pro Leu Ile Gln Glu Val Thr Thr Thr Leu
                85                  90                  95      
Arg Glu Trp Ser Thr Ile Trp Arg Gln Leu Tyr Val Gln Asp Asn Arg
            100                 105                 110         
Glu Met Phe Arg Ser Val Arg His Met Ile Tyr Asp Leu Ile Glu Trp
        115                 120                 125             
Arg Ser Gln Ile Leu Ser Gly Thr Leu Pro Gln Asp Glu Leu Lys Glu
    130                 135                 140                 
Leu Lys Lys Lys Val Thr Ala Lys Ile Asp Tyr Gly Asn Arg Ile Leu
145                 150                 155                 160 
Asp Leu Asp Leu Val Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro
                165                 170                 175     
Glu Leu Thr Ser Thr Ile Ser Leu Phe Arg Ala His Glu Ile Ala Ser
            180                 185                 190         
Lys Gln Val Glu Glu Arg Leu Gln Glu Glu Lys Ser Gln Lys Gln Asn
        195                 200                 205             
Ile Asp Ile Asn Arg Gln Ala Lys Phe Ala Ala Thr Pro Ser Leu Ala
    210                 215                 220                 
Leu Phe Val Asn Leu Lys Asn Val Val Cys Lys Ile Gly Glu Asp Ala
225                 230                 235                 240 
Glu Val Leu Met Ser Leu Tyr Asp Pro Val Glu Ser Lys Phe Ile Ser
                245                 250                 255     
Glu Asn Tyr Leu Val Arg Trp Ser Ser Ser Gly Leu Pro Lys Asp Ile
            260                 265                 270         
Asp Arg Leu His Asn Leu Arg Ala Val Phe Thr Asp Leu Gly Ser Lys
        275                 280                 285             
Asp Leu Lys Arg Glu Lys Ile Ser Phe Val Cys Gln Ile Val Arg Val
    290                 295                 300                 
Gly Arg Met Glu Leu Arg Asp Asn Asn Thr Arg Lys Leu Thr Ser Gly
305                 310                 315                 320 
Leu Arg Arg Pro Phe Gly Val Ala Val Met Asp Val Thr Asp Ile Ile
                325                 330                 335     
Asn Gly Lys Val Asp Asp Glu Asp Lys Gln His Phe Ile Pro Phe Gln
            340                 345                 350         
Pro Val Ala Gly Glu Asn Asp Phe Leu Gln Thr Val Ile Asn Lys Val
        355                 360                 365             
Ile Ala Ala Lys Glu Val Asn His Lys Gly Gln Gly Leu Trp Val Thr
    370                 375                 380                 
Leu Lys Leu Leu Pro Gly Asp Ile His Gln Ile Arg Lys Glu Phe Pro
385                 390                 395                 400 
His Leu Val Asp Arg Thr Thr Ala Val Ala Arg Lys Thr Gly Phe Pro
                405                 410                 415     
Glu Ile Ile Met Pro Gly Asp Val Arg Asn Asp Ile Tyr Val Thr Leu
            420                 425                 430         
Val Gln Gly Asp Phe Asp Lys Gly Ser Lys Thr Thr Ala Lys Asn Val
        435                 440                 445             
Glu Val Thr Val Ser Val Tyr Asp Glu Asp Gly Lys Arg Leu Glu His
    450                 455                 460                 
Val Ile Phe Pro Gly Ala Gly Asp Glu Ala Ile Ser Glu Tyr Lys Ser
465                 470                 475                 480 
Val Ile Tyr Tyr Gln Val Lys Gln Pro Arg Trp Phe Glu Thr Val Lys
                485                 490                 495     
Val Ala Ile Pro Ile Glu Asp Val Asn Arg Ser His Leu Arg Phe Thr
            500                 505                 510         
Phe Arg His Arg Ser Ser Gln Asp Ser Lys Asp Lys Ser Glu Lys Ile
        515                 520                 525             
Phe Ala Leu Ala Phe Val Lys Leu Met Arg Tyr Asp Gly Thr Thr Leu
    530                 535                 540                 
Arg Asp Gly Glu His Asp Leu Ile Val Tyr Lys Ala Glu Ala Lys Lys
545                 550                 555                 560 
Leu Glu Asp Ala Ala Thr Tyr Leu Ser Leu Pro Ser Thr Lys Ala Glu
                565                 570                 575     
Leu Glu Glu Lys Gly His Ser Ala Thr Gly Lys Ser Met Gln Ser Leu
            580                 585                 590         
Gly Ser Cys Thr Ile Ser Lys Asp Ser Phe Gln Ile Ser Thr Leu Val
        595                 600                 605             
Cys Ser Thr Lys Leu Thr Gln Asn Val Asp Leu Leu Gly Leu Leu Lys
    610                 615                 620                 
Trp Arg Ser Asn Thr Ser Leu Leu Gln Gln Asn Leu Arg Gln Leu Met
625                 630                 635                 640 
Lys Val Asp Gly Gly Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp
                645                 650                 655     
Ala Leu Phe Asn Ile Met Met Glu Asn Ser Glu Ser Glu Thr Phe Asp
            660                 665                 670         
Thr Leu Val Phe Asp Ala Leu Val Phe Ile Ile Gly Leu Ile Ala Asp
        675                 680                 685             
Arg Lys Phe Gln His Phe Asn Pro Val Leu Glu Thr Tyr Ile Lys Lys
    690                 695                 700                 
His Phe Ser Ala Thr Leu Ala Tyr Thr Lys Leu Thr Lys Val Leu Lys
705                 710                 715                 720 
Asn Tyr Val Asp Gly Ala Glu Lys Pro Gly Val Asn Glu Gln Leu Tyr
                725                 730                 735     
Lys Ala Met Lys Ala Leu Glu Ser Ile Phe Lys Phe Ile Val Arg Ser
            740                 745                 750         
Arg Ile Leu Phe Asn Gln Leu Tyr Glu Asn Lys Gly Glu Ala Asp Phe
        755                 760                 765             
Val Glu Ser Leu Leu Gln Leu Phe Arg Ser Ile Asn Asp Met Met Ser
    770                 775                 780                 
Ser Met Ser Asp Gln Thr Val Arg Val Lys Gly Ala Ala Leu Lys Tyr
785                 790                 795                 800 
Leu Pro Thr Ile Val Asn Asp Val Lys Leu Val Phe Asp Pro Lys Glu
                805                 810                 815     
Leu Ser Lys Met Phe Thr Glu Phe Ile Leu Asn Val Pro Met Gly Leu
            820                 825                 830         
Leu Thr Ile Gln Lys Leu Tyr Cys Leu Ile Glu Ile Val His Ser Asp
        835                 840                 845             
Leu Phe Thr Gln His Asp Cys Arg Glu Ile Leu Leu Pro Met Met Thr
    850                 855                 860                 
Asp Gln Leu Lys Tyr His Leu Glu Arg Gln Glu Asp Leu Glu Ala Cys
865                 870                 875                 880 
Cys Gln Leu Leu Ser His Ile Leu Glu Val Leu Tyr Arg Lys Asp Val
                885                 890                 895     
Gly Pro Thr Gln Arg His Val Gln Ile Ile Met Glu Lys Leu Leu Arg
            900                 905                 910         
Thr Val Asn Arg Thr Val Ile Ser Met Gly Arg Asp Ser Glu Leu Ile
        915                 920                 925             
Gly Asn Phe Val Ala Cys Met Thr Ala Ile Leu Arg Gln Met Glu Asp
    930                 935                 940                 
Tyr His Tyr Ala His Leu Ile Lys Thr Phe Gly Lys Met Arg Thr Asp
945                 950                 955                 960 
Val Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe Lys Asn Leu Ile
                965                 970                 975     
Gly Lys Asn Val Tyr Pro Phe Asp Trp Val Ile Met Asn Met Val Gln
            980                 985                 990         
Asn Lys Val Phe Leu Arg Ala Ile Asn Gln Tyr Ala Asp Met Leu Asn
        995                 1000                1005            
Lys Lys Phe Leu Asp Gln Ala Asn Phe Glu Leu Gln Leu Trp Asn Asn
    1010                1015                1020                
Tyr Phe His Leu Ala Val Ala Phe Leu Thr Gln Glu Ser Leu Gln Leu
1025                1030                1035                1040
Glu Asn Phe Ser Ser Ala Lys Arg Ala Lys Ile Leu Asn Lys Tyr Gly
                1045                1050                1055    
Asp Met Arg Arg Gln Ile Gly Phe Glu Ile Arg Asp Met Trp Tyr Asn
            1060                1065                1070        
Leu Gly Gln His Lys Ile Lys Phe Ile Pro Glu Met Val Gly Pro Ile
        1075                1080                1085            
Leu Glu Met Thr Leu Ile Pro Glu Thr Glu Leu Arg Lys Ala Thr Ile
    1090                1095                1100                
Pro Ile Phe Phe Asp Met Met Gln Cys Glu Phe His Ser Thr Arg Ser
1105                1110                1115                1120
Phe Gln Met Phe Glu Asn Glu Ile Ile Thr Lys Leu Asp His Glu Val
                1125                1130                1135    
Glu Gly Gly Arg Gly Asp Glu Gln Tyr Lys Val Leu Phe Asp Lys Ile
            1140                1145                1150        
Leu Leu Glu His Cys Arg Lys His Lys Tyr Leu Ala Lys Thr Gly Glu
        1155                1160                1165            
Thr Phe Val Lys Leu Val Val Arg Leu Met Glu Arg Leu Leu Asp Tyr
    1170                1175                1180                
Arg Thr Ile Met His Asp Glu Asn Lys Glu Asn Arg Met Ser Cys Thr
1185                1190                1195                1200
Val Asn Val Leu Asn Phe Tyr Lys Glu Ile Glu Arg Glu Glu Met Tyr
                1205                1210                1215    
Ile Arg Tyr Leu Tyr Lys Leu Cys Asp Leu His Lys Glu Cys Asp Asn
            1220                1225                1230        
Tyr Thr Glu Ala Ala Tyr Thr Leu Leu Leu His Ala Lys Leu Leu Lys
        1235                1240                1245            
Trp Ser Glu Asp Val Cys Val Ala His Leu Thr Gln Arg Asp Gly Tyr
    1250                1255                1260                
Gln Ala Thr Thr Gln Gly Gln Leu Lys Glu Gln Leu Tyr Gln Glu Ile
1265                1270                1275                1280
Ile His Tyr Phe Asp Lys Gly Lys Met Trp Glu Glu Ala Ile Ala Leu
                1285                1290                1295    
Gly Lys Glu Leu Ala Glu Gln Tyr Glu Asn Glu Met Phe Asp Tyr Glu
            1300                1305                1310        
Gln Leu Ser Glu Leu Leu Lys Lys Gln Ala Gln Phe Tyr Glu Asn Ile
        1315                1320                1325            
Val Lys Val Ile Arg Pro Lys Pro Asp Tyr Phe Ala Val Gly Tyr Tyr
    1330                1335                1340                
Gly Gln Gly Phe Pro Thr Phe Leu Arg Gly Lys Val Phe Ile Tyr Arg
1345                1350                1355                1360
Gly Lys Glu Tyr Glu Arg Arg Glu Asp Phe Glu Ala Arg Leu Leu Thr
                1365                1370                1375    
Gln Phe Pro Asn Ala Glu Lys Met Lys Thr Thr Ser Pro Pro Gly Asp
            1380                1385                1390        
Asp Ile Lys Asn Ser Pro Gly Gln Tyr Ile Gln Cys Phe Thr Val Lys
        1395                1400                1405            
Pro Lys Leu Asp Leu Pro Pro Lys Phe His Arg Pro Val Ser Glu Gln
    1410                1415                1420                
Ile Val Ser Phe Tyr Arg Val Asn Glu Val Gln Arg Phe Glu Tyr Ser
1425                1430                1435                1440
Arg Pro Ile Arg Lys Gly Glu Lys Asn Pro Asp Asn Glu Phe Ala Asn
                1445                1450                1455    
Met Trp Ile Glu Arg Thr Ile Tyr Thr Thr Ala Tyr Lys Leu Pro Gly
            1460                1465                1470        
Ile Leu Arg Trp Phe Glu Val Lys Ser Val Phe Met Val Glu Ile Ser
        1475                1480                1485            
Pro Leu Glu Asn Ala Ile Glu Thr Met Gln Leu Thr Asn Asp Lys Ile
    1490                1495                1500                
Asn Ser Met Val Gln Gln His Leu Asp Asp Pro Ser Leu Pro Ile Asn
1505                1510                1515                1520
Pro Leu Ser Met Leu Leu Asn Gly Ile Val Asp Pro Ala Val Met Gly
                1525                1530                1535    
Gly Phe Ala Asn Tyr Glu Lys Ala Phe Phe Thr Asp Arg Tyr Leu Gln
            1540                1545                1550        
Glu His Pro Glu Ala His Glu Lys Ile Glu Lys Leu Lys Asp Leu Ile
        1555                1560                1565            
Ala Trp Gln Ile Pro Phe Leu Ala Glu Gly Ile Arg Ile His Gly Asp
    1570                1575                1580                
Lys Val Thr Glu Ala Leu Arg Pro Phe His Glu Arg Met Glu Ala Cys
1585                1590                1595                1600
Phe Lys Gln Leu Lys Glu Lys Val Glu Lys Glu Tyr Gly Val Arg Ile
                1605                1610                1615    
Met Pro Ser Ser Leu Asp Asp Arg Arg Gly Ser Arg Pro Arg Ser Met
            1620                1625                1630        
Val Arg Ser Phe Thr Met Pro Ser Ser Ser Arg Pro Leu Ser Val Ala
        1635                1640                1645            
Ser Val Ser Ser Leu Ser Ser Asp Ser Thr Pro Ser Arg Pro Gly Ser
    1650                1655                1660                
Asp Gly Phe Ala Leu Glu Pro Leu Leu Pro Lys Lys Met His Ser Arg
1665                1670                1675                1680
Ser Gln Asp Lys Leu Asp Lys Asp Asp Leu Glu Lys Glu Lys Lys Asp
                1685                1690                1695    
Lys Lys Lys Glu Lys Arg Asn Ser Lys His Gln Glu Ile Phe Glu Lys
            1700                1705                1710        
Glu Phe Lys Pro Thr Asp Ile Ser Leu Gln Gln Ser Glu Ala Val Ile
        1715                1720                1725            
Leu Ser Glu Thr Ile Ser Pro Leu Arg Pro Gln Arg Pro Lys Ser Gln
    1730                1735                1740                
Val Met Asn Val Ile Gly Ser Glu Arg Arg Phe Ser Val Ser Pro Ser
1745                1750                1755                1760
Ser Pro Ser Ser Gln Gln Thr Pro Pro Pro Val Thr Pro Arg Ala Lys
                1765                1770                1775    
Leu Ser Phe Ser Met Gln Ser Ser Leu Glu Leu Asn Gly Met Thr Gly
            1780                1785                1790        
Ala Asp Val Ala Asp Val Pro Pro Pro Leu Pro Leu Lys Gly Ser Val
        1795                1800                1805            
Ala Asp Tyr Gly Asn Leu Met Glu Asn Gln Asp Leu Leu Gly Ser Pro
    1810                1815                1820                
Thr Pro Pro Pro Pro Pro Pro His Gln Arg His Leu Pro Pro Pro Leu
1825                1830                1835                1840
Pro Ser Lys Thr Pro Pro Pro Pro Pro Pro Lys Thr Thr Arg Lys Gln
                1845                1850                1855    
Thr Ser Val Asp Ser Gly Ile Val Gln
            1860                1865


<210> 7931
<211> 126
<212> PRT
<213> Homo sapiens

<400> 7931
Met Glu Val Leu Gly His Phe Gly Gln Gly Ser Asn Gly Tyr Leu Glu
 1               5                  10                  15      
Leu Ala Leu Pro Ser Ala Arg Gly Val Ser Val Cys Leu Arg Lys Trp
            20                  25                  30          
Gln Ser Ala Ile Gln Asp Phe Arg Ser Asn Ala Thr Ala Leu Cys His
        35                  40                  45              
Ile Arg Asn Gln Ala Trp Pro Gln Pro Glu Gly Thr Cys Ser Leu Met
    50                  55                  60                  
Gly Lys His Thr Lys Asn Lys Arg Ala Ser Arg Thr Cys Gly Ala Cys
65                  70                  75                  80  
Gly Pro Glu Thr Ala Gly Asn Gly Ser Gln Ala Arg Val Ala Gly Arg
                85                  90                  95      
Thr His Val Ala Gly Ser Val Gly Gly Ser Tyr Arg Gly Lys Arg Pro
            100                 105                 110         
Ser Gln Gln Leu Gly Glu Ala Ala Thr Pro Leu Val Asp Gly
        115                 120                 125     


<210> 7932
<211> 1770
<212> PRT
<213> Homo sapiens

<400> 7932
Met His Leu Asp Lys Asp Leu Glu Gln Ala Arg Ser Val Gly Ala His
 1               5                  10                  15      
Ser Gln Glu Met Gly Ile Thr Gln Ser Leu Gln Asn Leu Leu Gly Pro
            20                  25                  30          
Gln Gly Glu Thr His Thr Val Ile Asp Leu Tyr Trp Gly Val Glu Glu
        35                  40                  45              
Asp Glu Trp Asp Ser Pro Glu Leu Gln Lys Thr Arg Met Lys Leu Leu
    50                  55                  60                  
Glu Asn Cys Leu Lys Thr Ser Ala Val Trp Met Arg Trp Lys Phe Ala
65                  70                  75                  80  
Val Gly Glu Ala Leu Ala Gly Asp Pro Arg Arg Ala Lys Pro Asp Thr
                85                  90                  95      
Thr His Ala Met Arg Gly Ala Pro Leu Pro Pro Met Glu Ala Gly Leu
            100                 105                 110         
Ser Ala Asp Ser Ser Val Lys Lys Lys Lys Ile Pro Leu Glu Gln Trp
        115                 120                 125             
Ile Ser Arg Met Tyr Gly Gln Leu Ser Cys Phe Gly Leu Leu Gly Glu
    130                 135                 140                 
Lys Tyr Gly Asn Ile Arg Ile Pro Gly Glu Val Glu Ala Ser Glu Phe
145                 150                 155                 160 
Glu Met Ile Leu Asp Ala Ala Ile Glu Ala Lys Leu Glu Thr Lys Leu
                165                 170                 175     
Leu Glu Glu Trp Tyr Cys Arg Asp Glu Asn Ser Val Pro Ala Ala Tyr
            180                 185                 190         
Tyr Leu Arg Pro Lys Ser Glu Met Leu Arg Ser Asn Arg Asn Ala Met
        195                 200                 205             
Gln Pro Ser Thr Asn Ala Glu Asn Glu Lys Thr Trp Gln Glu Ile Ser
    210                 215                 220                 
Asp Glu Ile Lys Lys Ile Phe Lys Ala Ala Val Lys Leu Leu His Glu
225                 230                 235                 240 
Lys Gly Lys Met Lys His Ser Gln Ala Lys Arg Tyr Leu Phe Ser Ala
                245                 250                 255     
Ile Glu Asp Glu Phe Asp Phe Ala Leu Gly Lys Gln Thr Pro Ala Phe
            260                 265                 270         
Leu Lys Lys Cys Val Cys Tyr Ile Arg Lys Ile Ala Asn Ile Glu Arg
        275                 280                 285             
Phe Val Lys Ile Pro Glu Met Gly Lys Tyr Met Asp Ile Thr Gly Thr
    290                 295                 300                 
Glu Pro Arg Ile Ile Arg Asp Pro Glu Ala Gln Glu Lys Leu Ile Lys
305                 310                 315                 320 
Leu Arg Asp Glu Phe Ile Pro Thr Ile Val Ala Ser Ser Asn Leu Arg
                325                 330                 335     
Val Tyr Thr Ser Val Thr His Cys Asp Met Lys Leu Gly Tyr Ser Gln
            340                 345                 350         
Glu Ile Glu Asn His Tyr Ile Glu Gly Leu Gly Lys Gln Phe Tyr Glu
        355                 360                 365             
Asp Met Ile Asp Ile Ile Gln Ala Thr Ile Gln Gln Asn Phe Asp Thr
    370                 375                 380                 
Glu Thr Asp Thr Leu Tyr Asp Glu Ile Leu Gln His Ser Ser Leu Cys
385                 390                 395                 400 
Lys Thr Tyr Ala Ser Phe Tyr Glu Tyr Lys Cys Glu Ser Leu Asn Ile
                405                 410                 415     
Val His Asn Tyr Ile Leu Pro Ser Lys Ala Gly His Ile Asn Pro Leu
            420                 425                 430         
Ile Ile Tyr Asp Lys Asp Lys Pro Ser Gly His Ser Ser Leu Leu Asn
        435                 440                 445             
Gln Ser Pro Phe Ser Asn Glu Tyr Val Gln Ala Lys Ala Tyr Gly Trp
    450                 455                 460                 
Leu His Glu Asp Thr Gly Pro Glu Ser Asp Pro Val Val Ile Val Arg
465                 470                 475                 480 
Phe Leu Gly Thr Thr Asp Met Ser Ser Asp Leu Arg Thr Leu Leu Leu
                485                 490                 495     
Ser Val Cys Glu Gln Leu Ala Val Asn Tyr Arg Cys Leu Val Gln Ser
            500                 505                 510         
Tyr Pro Lys Lys Ile His Asp Leu Cys Asp Leu Phe Ile Asn Leu Leu
        515                 520                 525             
Asn Glu Ser Ser Leu Gln Arg Pro Leu Val Ile Ile Phe Asp Ala Leu
    530                 535                 540                 
Glu Gln Leu Ser Glu Asn Asp Asp Ala Arg Lys Leu Trp Trp Leu Pro
545                 550                 555                 560 
Ala His Leu Pro Arg Phe Val Arg Ile Val Leu Ser Thr Leu Pro Asn
                565                 570                 575     
Lys His Gly Ile Leu Gln Lys Leu Arg Cys Leu Ile His Glu Glu Asp
            580                 585                 590         
Asn Tyr Ile Glu Leu Ile Pro Arg Asp Arg Lys Met Cys Ser Gln Val
        595                 600                 605             
Leu Lys His Gln Leu Leu Arg Val Lys Arg Lys Val Thr Ser Gly Gln
    610                 615                 620                 
Gln Ile Tyr Val Asn Asn Ala Leu Ser Lys Cys Thr Leu Pro Met Phe
625                 630                 635                 640 
Val Asn Leu Thr Phe Arg Glu Val Arg His Trp Arg Ser His Lys Asp
                645                 650                 655     
Val Asp Glu Ser Ser Leu Ser Val Thr Val His Glu Ser Ile Glu Gln
            660                 665                 670         
Leu Phe Trp Ser Leu Glu Lys Lys Cys Gly Gln Lys Leu Val Ser Arg
        675                 680                 685             
Ala Leu Gly Tyr Ile Thr Met Ala Lys Met Gly Leu Ser Glu Met Glu
    690                 695                 700                 
Leu Glu Asp Val Leu Ala Leu Asp Asn Ser Val Met Ser Glu Leu Lys
705                 710                 715                 720 
Glu Asn Thr Arg Pro Ser Asn Pro Leu Arg Val Pro Tyr Leu Tyr Ile
                725                 730                 735     
Ala Arg Leu Lys Glu Gly Leu Ser Gly Tyr Leu Ile Glu Arg His Val
            740                 745                 750         
Lys Asn Val Thr Leu Leu Val Trp Ala Asn Arg His Leu Gln Leu Ile
        755                 760                 765             
Ala Gln Lys Leu Tyr Leu Gln Asp Asp Asn Asp Leu Arg Glu Met His
    770                 775                 780                 
Thr Ile Leu Ala Asp Tyr Phe Leu Gly Val Trp Ser Gly Gly Arg Arg
785                 790                 795                 800 
Lys Ala Phe Cys Leu Glu Asp Pro Tyr Leu Asn Gly Cys Leu Asp Leu
                805                 810                 815     
Glu Asn Arg Ser Leu Leu Glu Glu Glu Lys His Phe Met Glu Gln Ala
            820                 825                 830         
Ser Phe Asp Arg Gln Ala Pro Asp Gln Pro Trp Val Phe Gln Cys Asn
        835                 840                 845             
Pro Leu Glu Pro Asp Ile Phe Phe Val Asn His Arg Lys Met Ser Glu
    850                 855                 860                 
Leu Leu Tyr His Leu Thr Arg Cys Gly Lys Thr Asp Asp Leu Leu Tyr
865                 870                 875                 880 
Gly Ile Ile Met Asn Phe Ser Trp Leu Tyr Thr Met Ile Lys Ile Gly
                885                 890                 895     
Gln Phe Asp Lys Val Leu Ser Asp Ile Glu Leu Ala Tyr Asn Tyr Ser
            900                 905                 910         
Gln Glu Lys Glu Leu Lys Phe Leu Ala Asn Thr Leu Arg Ser Ile Lys
        915                 920                 925             
Asn Lys Val Thr Ala Phe Pro Gly Ser Leu Ser Ala Glu Leu Gln Gln
    930                 935                 940                 
Arg Leu Leu Pro Val Val Ser Ser Leu Pro Lys Leu Arg His Leu Leu
945                 950                 955                 960 
Leu Glu Cys Asp Lys Asp Gly Pro Lys Tyr Cys Ser Ile Val Pro Leu
                965                 970                 975     
His Ser Ser Met Asp Val Thr Tyr Ser Pro Glu Arg Leu Pro Leu Ser
            980                 985                 990         
Ser Ser His Leu His Val Thr Glu Ile Leu Pro Thr Cys Asn Pro Ser
        995                 1000                1005            
Thr Val Leu Thr Ala Leu Glu Asn Gly Ser Ile Ser Thr Trp Asp Val
    1010                1015                1020                
Glu Thr Arg Gln Leu Leu Arg Gln Ile Thr Thr Ala Gln Ser Val Ile
1025                1030                1035                1040
Leu Gly Met Lys Leu Thr Ser Asp Glu Lys Tyr Leu Val Val Ala Thr
                1045                1050                1055    
Thr Asn Asn Thr Leu Leu Ile Tyr Asp Asn Val Asn Ser Cys Leu Leu
            1060                1065                1070        
Ser Glu Val Glu Ile Lys Gly Thr Lys His Gly Ser Ser Ala Thr Tyr
        1075                1080                1085            
Ile Asn Gly Phe Thr Leu Ser Ala Asn His Ala Leu Ala Trp Leu Glu
    1090                1095                1100                
Ala Ser Lys Asp Val Thr Val Ile Asp Leu Leu Tyr Gly Trp Pro Leu
1105                1110                1115                1120
Tyr Gln Phe His Cys Trp Tyr Glu Val Thr Cys Val Gln Cys Ser Leu
                1125                1130                1135    
Asp Gly Leu Tyr Ala Phe Cys Gly Gln Tyr Leu Asn Thr Thr Thr Ile
            1140                1145                1150        
Phe His Leu Gly Ser Gly Glu Lys Leu Cys Thr Val Thr Ser Glu Phe
        1155                1160                1165            
Ser Gly Gly Phe Val Lys Phe Leu Leu Ile Leu Asp Thr Ala Gln Glu
    1170                1175                1180                
Met Val Met Val Asp Ser Glu Gly Ser Leu Ser Val Trp Asn Thr Glu
1185                1190                1195                1200
Asp Ile Ser Ser Pro Gln Leu Thr Asp Asp Phe Asp Cys Arg Arg Glu
                1205                1210                1215    
Asp Ser Glu Val Val Ser Ile Glu Leu Ser Glu Asp Gln Ser Ala Val
            1220                1225                1230        
Leu Ile Cys Lys Ala Leu Ser Ile Glu Leu Leu Asp Thr Gly Leu Trp
        1235                1240                1245            
Lys Val Ala Glu Lys Phe Arg Ala Lys His Asn Glu Arg Phe Ile Ser
    1250                1255                1260                
Ala Val Leu Ser Lys Asn Gly Asp Cys Ile Ile Ala Thr Met Glu Asn
1265                1270                1275                1280
Thr Ser Ala Val Phe Phe Trp Arg Arg Asp Thr Gly Gln Cys Met Ala
                1285                1290                1295    
Ser Leu Gln Glu Ile Ser Gly Ser Ile Val Lys Leu Val Lys Ser Ser
            1300                1305                1310        
His His Asn Met Leu Leu Ser Leu Ser Thr Ser Gly Val Leu Ser Ile
        1315                1320                1325            
Trp Asp Ile Asp Ile Ile Thr Ala Met Ser Asn Ile Asp Lys Thr Gly
    1330                1335                1340                
Lys Pro Ile Gln Ser Leu Leu Leu Pro Ala Arg Gly Glu Ile Ile Tyr
1345                1350                1355                1360
Ser Leu Asp Gly Ser Asp Cys Val His Lys Trp Asn Phe Ser Ser Gly
                1365                1370                1375    
Phe Ile Glu Ala Val Phe Lys His Glu Gly Ile Val Glu His Cys Val
            1380                1385                1390        
Leu Thr Ser Thr Gly Asp Ile Met Val Thr Ser Asp Asp Lys Ser Ser
        1395                1400                1405            
Gln Tyr Val Trp His Thr Ser Ser Gly Glu Asn Leu Phe Arg Ile Asn
    1410                1415                1420                
Gly Gln Arg Ile Ser Gln Leu Leu Ile Thr His Asn Asp Gln Phe Val
1425                1430                1435                1440
Val Ser Leu Cys Glu Glu Asn Ala Ser Arg Val Trp Arg Leu Ala Thr
                1445                1450                1455    
Gly His Arg Val Cys Asn Ile Leu Thr Thr Leu Gln Asn Ala Phe Ile
            1460                1465                1470        
Thr Ser Ala Asn Thr Phe Val Val Gly Met Thr Lys Ser Lys Val Leu
        1475                1480                1485            
Ala Val Ser Leu Trp Thr Gly Ser Ile Thr Lys Lys Phe Cys Cys Glu
    1490                1495                1500                
Asp Gly Thr Thr Ile Val Asn Phe Lys Leu Ile Pro Asp Cys Pro Asp
1505                1510                1515                1520
Ile Ile Val Phe Ile Thr Ser Ala Glu Thr Val Asn Ile Trp Ser Leu
                1525                1530                1535    
Thr Asp Glu Val Ile Cys Arg Arg Val Gln Leu Pro Asn Asn Phe Leu
            1540                1545                1550        
Lys Asn Leu Glu Asp Phe Glu Ile Ser Pro Asn Gly Lys Leu Gly Ile
        1555                1560                1565            
Ile Ala Arg Gly Asp Glu Asn Ile Asn Val Leu Asp Leu Tyr Ser Gly
    1570                1575                1580                
Lys Leu Arg Val Val His Ala Ser Gly Ile Ile Trp Arg Gln Arg Leu
1585                1590                1595                1600
Ser Arg Asp Gly Arg Tyr Leu Val Tyr Ile Cys Phe Arg Asn Gly Glu
                1605                1610                1615    
Glu Glu Asp Glu Asn Gly Ala Ile Phe Ser Leu Ile Val Met Arg Leu
            1620                1625                1630        
Ala Asp Gly Lys Asn Ile Gly Ala Cys Ser Leu Tyr Lys Thr Pro Thr
        1635                1640                1645            
Phe Leu Ala Leu Ser Gln Arg His Leu Asn Ile Ile Val Gly Phe Asp
    1650                1655                1660                
Asp Gly Ser Ile Gly Ile Tyr Thr Val Val Asp Arg Val Asp Ala Ala
1665                1670                1675                1680
Leu Lys Ile Lys Ile Ala Thr Ser Asn Ser Arg Gln Ile Phe Asn Asn
                1685                1690                1695    
Ala Thr His Thr Ser Arg Pro Lys Cys Asn Ser Tyr Cys Phe Lys Ile
            1700                1705                1710        
Ser Val Asp Cys Leu Trp Arg Glu Ser Thr Glu Val Phe Ala Arg Asp
        1715                1720                1725            
Ser Pro Ile Thr Val Ser Asp Ser Thr Glu Ser Asn Glu Ala Thr Pro
    1730                1735                1740                
Ser Lys Lys His Asn Ser Cys Tyr Glu Arg Val Cys Ser Ala Leu Glu
1745                1750                1755                1760
Ala Arg Gly His Ser Tyr Ala Pro Asp Asn
                1765                1770


<210> 7933
<211> 477
<212> PRT
<213> Homo sapiens

<400> 7933
Met Ala Thr Tyr Thr Cys Ile Thr Cys Arg Val Ala Phe Arg Asp Ala
 1               5                  10                  15      
Asp Met Gln Arg Ala His Tyr Lys Thr Asp Trp His Arg Tyr Asn Leu
            20                  25                  30          
Arg Arg Lys Val Ala Ser Met Ala Pro Val Thr Ala Glu Gly Phe Gln
        35                  40                  45              
Glu Arg Val Arg Ala Gln Arg Ala Val Ala Glu Glu Glu Ser Lys Gly
    50                  55                  60                  
Ser Ala Thr Tyr Cys Thr Val Cys Ser Lys Lys Phe Ala Ser Phe Asn
65                  70                  75                  80  
Ala Tyr Glu Asn His Leu Lys Ser Arg Arg His Val Glu Leu Glu Lys
                85                  90                  95      
Lys Ala Val Gln Ala Val Asn Arg Lys Val Glu Met Met Asn Glu Lys
            100                 105                 110         
Asn Leu Glu Lys Gly Leu Gly Val Asp Ser Val Asp Lys Asp Ala Met
        115                 120                 125             
Asn Ala Ala Ile Gln Gln Ala Ile Lys Ala Gln Pro Ser Met Ser Pro
    130                 135                 140                 
Lys Lys Ala Pro Pro Ala Pro Ala Lys Glu Ala Arg Asn Val Val Ala
145                 150                 155                 160 
Val Gly Thr Gly Gly Arg Gly Thr His Asp Arg Asp Pro Ser Glu Lys
                165                 170                 175     
Pro Pro Arg Leu Gln Trp Phe Glu Gln Gln Ala Lys Lys Leu Ala Lys
            180                 185                 190         
Gln Gln Glu Glu Asp Ser Glu Glu Glu Glu Glu Asp Leu Asp Gly Asp
        195                 200                 205             
Asp Trp Glu Asp Ile Asp Ser Asp Glu Glu Leu Glu Cys Glu Asp Thr
    210                 215                 220                 
Glu Ala Met Asp Asp Val Val Glu Gln Asp Ala Glu Glu Glu Glu Ala
225                 230                 235                 240 
Glu Glu Gly Pro Pro Leu Gly Ala Ile Pro Ile Thr Asp Cys Leu Phe
                245                 250                 255     
Cys Ser His His Ser Ser Ser Leu Met Lys Asn Val Ala His Met Thr
            260                 265                 270         
Lys Asp His Ser Phe Phe Ile Pro Asp Ile Glu Tyr Leu Ser Asp Ile
        275                 280                 285             
Lys Gly Leu Ile Lys Tyr Leu Gly Glu Lys Val Gly Val Gly Lys Ile
    290                 295                 300                 
Cys Leu Trp Cys Asn Glu Lys Gly Lys Ser Phe Tyr Ser Thr Glu Ala
305                 310                 315                 320 
Val Gln Ala His Met Asn Asp Lys Ser His Cys Lys Leu Phe Thr Asp
                325                 330                 335     
Gly Asp Ala Ala Leu Glu Phe Ala Asp Phe Tyr Asp Phe Arg Ser Ser
            340                 345                 350         
Tyr Pro Asp His Lys Glu Gly Glu Asp Pro Asn Lys Ala Glu Glu Leu
        355                 360                 365             
Pro Ser Glu Lys Asn Leu Glu Tyr Asp Asp Glu Thr Met Glu Leu Ile
    370                 375                 380                 
Leu Pro Ser Gly Ala Arg Val Gly His Arg Ser Leu Met Arg Tyr Tyr
385                 390                 395                 400 
Lys Gln Arg Phe Gly Leu Ser Arg Ala Val Ala Val Ala Lys Asn Arg
                405                 410                 415     
Lys Ala Val Gly Arg Val Leu Gln Gln Tyr Arg Ala Leu Gly Trp Thr
            420                 425                 430         
Gly Ser Thr Gly Ala Ala Leu Met Arg Glu Arg Asp Met Gln Tyr Val
        435                 440                 445             
Gln Arg Met Lys Ser Lys Trp Met Leu Lys Thr Gly Met Lys Asn Asn
    450                 455                 460                 
Ala Thr Lys Gln Met His Phe Arg Val Gln Val Arg Phe
465                 470                 475         


<210> 7934
<211> 1077
<212> PRT
<213> Homo sapiens

<400> 7934
Met Pro Arg Arg Lys Gln Glu Gln Pro Lys Arg Leu Pro Ser His Val
 1               5                  10                  15      
Ser Arg Gln Glu Glu Ala Glu Gly Glu Leu Ser Glu Gly Glu His Trp
            20                  25                  30          
Tyr Gly Asn Ser Ser Glu Ala Pro Ser Glu Ala Ser Tyr Gly Glu Val
        35                  40                  45              
Gln Glu Asn Tyr Lys Leu Ser Leu Glu Asp Arg Ile Gln Glu Gln Ser
    50                  55                  60                  
Thr Ser Pro Asp Thr Ser Leu Gly Ser Thr Thr Pro Ser Ser His Thr
65                  70                  75                  80  
Leu Glu Leu Val Ala Leu Asp Ser Glu Val Leu Arg Asp Ser Leu Gln
                85                  90                  95      
Cys Gln Asp His Leu Ser Pro Gly Val Ser Ser Leu Cys Asp Asp Asp
            100                 105                 110         
Pro Gly Ser Asn Lys Pro Leu Ser Ser Asn Leu Arg Arg Leu Leu Glu
        115                 120                 125             
Ala Gly Ser Leu Lys Leu Asp Ala Ala Ala Thr Ala Asn Gly Arg Val
    130                 135                 140                 
Glu Ser Pro Val Asn Val Gly Ser Asn Leu Ser Phe Ser Pro Pro Ser
145                 150                 155                 160 
His His Ala Arg Gln Leu Ser Val Leu Ala Arg Lys Leu Ala Glu Lys
                165                 170                 175     
Gln Glu Gln Asn Asp Gln Tyr Thr Pro Ser Asn Arg Phe Ile Trp Asn
            180                 185                 190         
Gln Gly Lys Trp Leu Pro Asn Ser Thr Thr Thr Cys Ser Leu Ser Pro
        195                 200                 205             
Asp Ser Ala Ile Leu Lys Leu Lys Ala Ala Ala Asn Ala Val Leu Gln
    210                 215                 220                 
Asp Lys Ser Leu Thr Arg Thr Glu Glu Thr Met Arg Phe Glu Ser Leu
225                 230                 235                 240 
Ser Ser Pro Phe Ser Ser Gln Ser Ala Ser Ser Thr Leu Ala Ala Leu
                245                 250                 255     
Ser Lys Lys Val Ser Glu Arg Ser Leu Thr Pro Gly Gln Glu His Pro
            260                 265                 270         
Pro Pro Ala Ser Ser Phe Leu Ser Leu Ala Ser Met Thr Ser Ser Ala
        275                 280                 285             
Ala Leu Leu Lys Glu Val Ala Ala Arg Ala Ala Gly Ser Leu Leu Ala
    290                 295                 300                 
Glu Lys Ser Ser Leu Leu Pro Glu Asp Pro Leu Pro Pro Pro Pro Ser
305                 310                 315                 320 
Glu Lys Lys Pro Glu Lys Val Thr Pro Pro Pro Pro Pro Pro Pro Pro
                325                 330                 335     
Pro Pro Pro Pro Pro Pro Pro Gln Ser Leu Glu Leu Leu Leu Leu Pro
            340                 345                 350         
Val Pro Lys Gly Arg Val Ser Lys Pro Ser Asn Ser Ala Ser Glu Glu
        355                 360                 365             
Glu Ser Gly Lys Pro Phe Gln Cys Pro Ile Cys Gly Leu Val Ile Lys
    370                 375                 380                 
Arg Lys Ser Tyr Trp Lys Arg His Met Val Ile His Thr Gly Leu Lys
385                 390                 395                 400 
Ser His Gln Cys Pro Leu Cys Pro Phe Arg Cys Ala Arg Lys Asp Asn
                405                 410                 415     
Leu Lys Ser His Met Lys Val His Gln His Gln Asp Arg Gly Glu Thr
            420                 425                 430         
Phe Gln Cys Gln Leu Cys Pro Phe Thr Ser Ser Arg His Phe Ser Leu
        435                 440                 445             
Lys Leu His Met Arg Cys His Gln His Phe Leu Arg Thr Glu Ala Lys
    450                 455                 460                 
Val Lys Glu Glu Ile Pro Asp Pro Asp Val Lys Gly Ser Pro His Leu
465                 470                 475                 480 
Ser Asp Ser Ala Cys Leu Gly Gln Gln Arg Glu Gly Gly Gly Thr Glu
                485                 490                 495     
Leu Val Gly Thr Met Met Thr Ser Asn Thr Pro Glu Arg Thr Ser Gln
            500                 505                 510         
Gly Gly Ala Gly Val Ser Pro Leu Leu Val Lys Glu Glu Pro Lys Glu
        515                 520                 525             
Asp Asn Gly Leu Pro Thr Ser Phe Thr Leu Asn Ala Ala Asp Arg Pro
    530                 535                 540                 
Ala Asn His Thr Lys Leu Lys Asp Pro Ser Glu Tyr Val Ala Asn Ser
545                 550                 555                 560 
Ala Ser Ala Leu Phe Ser Gln Asp Ile Ser Val Lys Met Ala Ser Asp
                565                 570                 575     
Phe Leu Met Lys Leu Ser Ala Ala Asn Gln Lys Glu Pro Met Asn Leu
            580                 585                 590         
Asn Phe Lys Val Lys Glu Glu Pro Lys Glu Gly Glu Ser Leu Ser Thr
        595                 600                 605             
Thr Leu Pro Arg Ser Ser Tyr Val Phe Ser Pro Glu Ser Glu Val Ser
    610                 615                 620                 
Ala Pro Gly Val Ser Glu Asp Ala Leu Lys Pro Gln Glu Gly Lys Gly
625                 630                 635                 640 
Ser Val Leu Arg Arg Asp Val Ser Val Lys Ala Ala Ser Glu Leu Leu
                645                 650                 655     
Met Lys Leu Ser Ala Glu Ser Tyr Lys Glu Thr Gln Met Val Lys Ile
            660                 665                 670         
Lys Glu Glu Pro Met Glu Val Asp Ile Gln Asp Ser His Val Ser Ile
        675                 680                 685             
Ser Pro Ser Arg Asn Val Gly Tyr Ser Thr Leu Ile Gly Arg Glu Lys
    690                 695                 700                 
Thr Glu Pro Leu Gln Lys Met Pro Glu Gly Arg Val Pro Pro Glu Arg
705                 710                 715                 720 
Asn Leu Phe Ser Gln Asp Ile Ser Val Lys Met Ala Ser Glu Leu Leu
                725                 730                 735     
Phe Gln Leu Ser Glu Lys Val Ser Lys Glu His Asn His Thr Lys Glu
            740                 745                 750         
Asn Thr Ile Arg Thr Thr Thr Ser Pro Phe Phe Ser Glu Asp Thr Phe
        755                 760                 765             
Arg Gln Ser Pro Phe Thr Ser Asn Ser Lys Glu Leu Leu Pro Ser Asp
    770                 775                 780                 
Ser Val Leu His Gly Arg Ile Ser Ala Pro Glu Thr Glu Lys Ile Val
785                 790                 795                 800 
Leu Glu Ala Gly Asn Gly Leu Pro Ser Trp Lys Phe Asn Asp Gln Leu
                805                 810                 815     
Phe Pro Cys Asp Val Cys Gly Lys Val Phe Gly Arg Gln Gln Thr Leu
            820                 825                 830         
Ser Arg His Leu Ser Leu His Thr Glu Glu Arg Lys Tyr Lys Cys His
        835                 840                 845             
Leu Cys Pro Tyr Ala Ala Lys Cys Arg Ala Asn Leu Asn Gln His Leu
    850                 855                 860                 
Thr Val His Ser Val Lys Leu Val Ser Thr Asp Thr Glu Asp Ile Val
865                 870                 875                 880 
Ser Ala Val Thr Ser Glu Gly Ser Asp Gly Lys Lys His Pro Tyr Tyr
                885                 890                 895     
Tyr Ser Cys His Val Cys Gly Phe Gly Thr Glu Leu Asn Val Gln Phe
            900                 905                 910         
Val Ser His Met Ser Leu His Val Asp Lys Glu Gln Trp Met Phe Ser
        915                 920                 925             
Ile Cys Cys Thr Ala Cys Asp Phe Val Thr Met Glu Glu Ala Glu Ile
    930                 935                 940                 
Lys Thr His Ile Gly Thr Lys His Thr Gly Glu Asp Arg Lys Thr Pro
945                 950                 955                 960 
Ser Glu Ser Asn Ser Pro Ser Ser Ser Ser Leu Ser Ala Leu Ser Asp
                965                 970                 975     
Ser Ala Asn Ser Lys Asp Asp Ser Asp Gly Ser Gln Lys Asn Lys Gly
            980                 985                 990         
Gly Asn Asn Leu Leu Val Ile Ser Val Met Pro Gly Ser Gln Pro Ser
        995                 1000                1005            
Leu Asn Ser Glu Glu Lys Pro Glu Lys Gly Phe Glu Cys Val Phe Cys
    1010                1015                1020                
Asn Phe Val Cys Lys Thr Lys Asn Met Phe Glu Arg His Leu Gln Ile
1025                1030                1035                1040
His Leu Ile Thr Arg Met Phe Glu Cys Asp Val Cys His Lys Phe Met
                1045                1050                1055    
Lys Thr Pro Glu Gln Leu Leu Glu His Lys Lys Cys His Thr Val Pro
            1060                1065                1070        
Thr Gly Gly Leu Lys
        1075        


<210> 7935
<211> 229
<212> PRT
<213> Homo sapiens

<400> 7935
Met Trp Ala Ala Gly Arg Trp Gly Pro Thr Phe Pro Ser Ser Tyr Ala
 1               5                  10                  15      
Gly Phe Ser Ala Asp Cys Arg Pro Arg Ser Arg Pro Ser Ser Asp Ser
            20                  25                  30          
Cys Ser Val Pro Met Thr Gly Ala Arg Gly Gln Gly Leu Glu Val Val
        35                  40                  45              
Arg Ser Pro Ser Pro Pro Leu Pro Leu Ser Cys Ser Asn Ser Thr Arg
    50                  55                  60                  
Ser Leu Leu Ser Pro Leu Gly His Gln Ser Phe Gln Phe Asp Glu Asp
65                  70                  75                  80  
Asp Gly Asp Gly Glu Asp Glu Glu Asp Val Asp Asp Glu Glu Asp Val
                85                  90                  95      
Asp Glu Asp Ala His Asp Ser Glu Ala Lys Val Ala Ser Leu Arg Gly
            100                 105                 110         
Met Glu Leu Gln Gly Cys Ala Ser Thr Gln Val Glu Ser Glu Asn Asn
        115                 120                 125             
Gln Glu Glu Gln Lys Gln Val Arg Leu Pro Glu Ser Arg Leu Thr Pro
    130                 135                 140                 
Trp Glu Val Trp Phe Ile Gly Lys Glu Lys Glu Glu Arg Asp Arg Leu
145                 150                 155                 160 
Gln Leu Lys Ala Leu Glu Glu Leu Asn Gln Gln Leu Glu Lys Arg Lys
                165                 170                 175     
Glu Met Glu Glu Arg Glu Lys Arg Lys Ile Ile Ala Glu Glu Lys His
            180                 185                 190         
Lys Glu Trp Val Gln Lys Lys Asn Glu Gln Val Arg Arg Gly Lys Trp
        195                 200                 205             
Ile His Thr Leu Thr Ser Leu Leu Gln Asn Ile Ser Ser Tyr Tyr Thr
    210                 215                 220                 
Ser Leu Pro Arg Phe
225                 


<210> 7936
<211> 885
<212> PRT
<213> Homo sapiens

<400> 7936
Met Val Glu Lys Ser Ser Ile Asp Glu Asn Ser Ile Ser Leu Glu Lys
 1               5                  10                  15      
Glu Val Arg His Val Gln Glu Gln Asn Leu Asp Ile Leu Lys Thr Asp
            20                  25                  30          
Leu Pro Leu Lys Ser Phe Ser Glu Glu Ile Tyr Ser Glu Ser Cys Ala
        35                  40                  45              
Leu Leu Pro Thr Ser Ser Ala Asp Ile Glu Glu Thr Asp Leu Ser Glu
    50                  55                  60                  
Lys Ser Cys Pro Leu Glu Asn Gly Gly Arg Ser Ser Ile Ser His Leu
65                  70                  75                  80  
Lys Lys Ala Ala Ser Glu Glu Lys Pro Leu Gly Val Gly Glu Met Glu
                85                  90                  95      
Glu Glu Cys Thr Leu Glu Pro Glu Leu Ala Ala Phe Pro Lys Gln Asp
            100                 105                 110         
Gly Gly Thr Gln Glu Tyr Thr Asp Ala Thr Leu Glu Asp His Arg Gly
        115                 120                 125             
Asp Val Gln Glu Ala Asp Thr Leu His Arg Gln Leu Ser Leu Ser Gln
    130                 135                 140                 
Cys Phe Pro Leu Leu Met Thr Glu Glu Gln Gln Asn Pro Gly Glu Gln
145                 150                 155                 160 
Ile Ser Thr Asn Ile His Ala Ser Gly Glu Glu Lys Cys Tyr Glu Glu
                165                 170                 175     
Val Gln Val Gln Asn Glu Ala Ser Phe Ser Thr Leu Glu Gly Glu Met
            180                 185                 190         
Ile Glu Thr Ser Phe Ser Gln Asn Ile Pro Lys Leu Asp Glu Ala His
        195                 200                 205             
Thr Thr Glu Ala Ala Glu Ser Glu Thr Ser Leu Thr Gln Tyr Leu Leu
    210                 215                 220                 
Ala Ala Gly Lys Arg Glu Val Pro Glu Thr Lys Asp Thr Arg Asp Gln
225                 230                 235                 240 
Ala Lys Leu Val Gln Ser Glu Ser Ile Thr Ser Met Glu Val Glu Glu
                245                 250                 255     
Val Thr Phe Asn Thr Val Tyr Glu Tyr Tyr Asn Gln Lys Gln Glu Ser
            260                 265                 270         
Leu Gly Arg Pro Leu Ser Pro Glu Ser Asp Ile Ser Ile Gly Val Gly
        275                 280                 285             
Ser Thr Thr Ser Glu Glu Ile Ser Glu Leu Asp Gln Phe Tyr Thr Pro
    290                 295                 300                 
Pro Ser Ser Val Glu Tyr Phe Glu Ser Pro Lys Ser Pro Asp Leu Tyr
305                 310                 315                 320 
Phe Asn Pro Ser Asp Ile Thr Lys Gln Ser Ser Ile His Ser Gly Gly
                325                 330                 335     
Glu Thr Val Glu Arg Tyr Ser Thr Pro Leu Gly Glu Val Ala Glu Arg
            340                 345                 350         
Tyr Ser Thr Pro Ser Glu Gly Glu Val Gly Glu Arg Tyr Ser Thr Pro
        355                 360                 365             
Pro Gly Glu Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Thr Leu
    370                 375                 380                 
Glu Arg Tyr Ser Thr Pro Pro Gly Glu Ala Leu Glu Arg Tyr Ser Ile
385                 390                 395                 400 
Pro Thr Gly Gly Pro Asn Pro Thr Gly Thr Phe Lys Thr Tyr Pro Ser
                405                 410                 415     
Lys Ile Glu Arg Glu Asp Gly Thr Pro Asn Glu His Phe Tyr Thr Pro
            420                 425                 430         
Thr Glu Glu Arg Gly Ser Ala Tyr Glu Ile Trp Arg Ser Asp Ser Phe
        435                 440                 445             
Gly Thr Pro Asn Glu Ala Ile Glu Pro Lys Asp Asn Glu Met Pro Pro
    450                 455                 460                 
Ser Phe Ile Glu Pro Leu Thr Lys Arg Lys Val Tyr Glu Asn Thr Thr
465                 470                 475                 480 
Leu Gly Phe Ile Val Glu Val Glu Gly Leu Pro Val Pro Gly Val Lys
                485                 490                 495     
Trp Tyr Arg Asn Lys Ser Leu Leu Glu Pro Asp Glu Arg Ile Lys Met
            500                 505                 510         
Glu Arg Val Gly Asn Val Cys Ser Leu Glu Ile Ser Asn Ile Gln Lys
        515                 520                 525             
Gly Glu Gly Gly Glu Tyr Met Cys His Ala Val Asn Ile Ile Gly Glu
    530                 535                 540                 
Ala Lys Ser Phe Ala Asn Val Asp Ile Met Pro Gln Glu Glu Arg Val
545                 550                 555                 560 
Val Ala Leu Pro Pro Pro Val Thr His Gln His Val Met Glu Phe Asp
                565                 570                 575     
Leu Glu His Thr Thr Ser Ser Arg Thr Pro Ser Pro Gln Glu Ile Val
            580                 585                 590         
Leu Glu Val Glu Leu Ser Glu Lys Asp Val Lys Glu Phe Glu Lys Gln
        595                 600                 605             
Val Lys Ile Val Thr Val Pro Asp Phe Thr Pro Asp His Lys Ser Met
    610                 615                 620                 
Ile Val Ser Leu Asp Val Leu Pro Phe Asn Phe Val Asp Pro Asn Met
625                 630                 635                 640 
Asp Ser Arg Glu Gly Glu Asp Lys Glu Leu Lys Ile Asp Leu Glu Val
                645                 650                 655     
Phe Glu Met Pro Pro Arg Phe Ile Met Pro Ile Cys Asp Phe Lys Ile
            660                 665                 670         
Pro Glu Asn Ser Asp Ala Val Phe Lys Cys Ser Val Ile Gly Ile Pro
        675                 680                 685             
Thr Pro Glu Val Lys Trp Tyr Lys Glu Tyr Met Cys Ile Glu Pro Asp
    690                 695                 700                 
Asn Ile Lys Tyr Val Ile Ser Glu Glu Lys Gly Ser His Thr Leu Lys
705                 710                 715                 720 
Ile Arg Asn Val Cys Leu Ser Asp Ser Ala Thr Tyr Arg Cys Arg Ala
                725                 730                 735     
Val Asn Cys Val Gly Glu Ala Ile Cys Arg Gly Phe Leu Thr Met Gly
            740                 745                 750         
Asp Ser Glu Ile Phe Ala Val Ile Ala Lys Lys Ser Lys Val Thr Leu
        755                 760                 765             
Ser Ser Leu Met Glu Glu Leu Val Leu Lys Ser Asn Tyr Thr Asp Ser
    770                 775                 780                 
Phe Phe Glu Phe Gln Val Val Glu Gly Pro Pro Arg Phe Ile Lys Gly
785                 790                 795                 800 
Ile Ser Asp Cys Tyr Ala Pro Ile Gly Thr Ala Ala Tyr Phe Gln Cys
                805                 810                 815     
Leu Val Arg Gly Ser Pro Arg Pro Thr Val Tyr Trp Tyr Lys Asp Gly
            820                 825                 830         
Lys Leu Val Gln Gly Arg Arg Phe Thr Val Glu Glu Ser Gly Thr Gly
        835                 840                 845             
Phe His Asn Leu Phe Ile Thr Ser Leu Val Lys Ser Asp Glu Gly Glu
    850                 855                 860                 
Tyr Arg Cys Val Ala Thr Asn Lys Ser Gly Met Ala Glu Ser Phe Ala
865                 870                 875                 880 
Ala Leu Thr Leu Thr
                885 


<210> 7937
<211> 5607
<212> PRT
<213> Homo sapiens

<400> 7937
Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val
 1               5                  10                  15      
Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe
            20                  25                  30          
Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr
        35                  40                  45              
Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys
    50                  55                  60                  
Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu
65                  70                  75                  80  
Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu
                85                  90                  95      
Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser
            100                 105                 110         
Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr
        115                 120                 125             
Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile
    130                 135                 140                 
Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser
145                 150                 155                 160 
Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val
                165                 170                 175     
Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu
            180                 185                 190         
Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val
        195                 200                 205             
Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys
    210                 215                 220                 
Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val
225                 230                 235                 240 
Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro Pro Arg
                245                 250                 255     
Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala
            260                 265                 270         
Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His
        275                 280                 285             
Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val
    290                 295                 300                 
Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser
305                 310                 315                 320 
Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala
                325                 330                 335     
Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala
            340                 345                 350         
Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr
        355                 360                 365             
Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu
    370                 375                 380                 
Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala
385                 390                 395                 400 
Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val
                405                 410                 415     
Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala
            420                 425                 430         
Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln
        435                 440                 445             
Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln
    450                 455                 460                 
Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val
465                 470                 475                 480 
Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys
                485                 490                 495     
Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln
            500                 505                 510         
Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser
        515                 520                 525             
Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr
    530                 535                 540                 
Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Arg Gln Glu Thr Glu
545                 550                 555                 560 
Ile Thr Ala Ala Ser Met Val Val Val Ala Thr Ala Lys Ser Thr Lys
                565                 570                 575     
Leu Glu Thr Val Pro Gly Ala Gln Glu Glu Thr Thr Thr Gln Gln Asp
            580                 585                 590         
Gln Met His Leu Ser Tyr Glu Lys Ile Met Lys Glu Thr Arg Lys Thr
        595                 600                 605             
Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu Gln Asp
    610                 615                 620                 
Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu Gln Val
625                 630                 635                 640 
Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr Ala Leu
                645                 650                 655     
Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu Thr Ile
            660                 665                 670         
Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile Gln Val
        675                 680                 685             
Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val Ala Thr
    690                 695                 700                 
Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg Glu Pro
705                 710                 715                 720 
Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu Tyr Gly
                725                 730                 735     
Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro Gln Arg
            740                 745                 750         
Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro Arg Val
        755                 760                 765             
Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln Lys Gly
    770                 775                 780                 
Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr Thr Glu
785                 790                 795                 800 
Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro His Phe
                805                 810                 815     
Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr Glu Ala
            820                 825                 830         
Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu Ser Ala
        835                 840                 845             
Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro Thr Val
    850                 855                 860                 
Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu Pro Gln
865                 870                 875                 880 
Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala Gly Val
                885                 890                 895     
Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr Val Arg
            900                 905                 910         
Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val Thr Glu
        915                 920                 925             
Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro Pro Thr
    930                 935                 940                 
Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu Ser Val
945                 950                 955                 960 
Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val Thr Trp
                965                 970                 975     
Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln Ile Thr
            980                 985                 990         
Phe Gln Ser Gly Ile Ala Arg Leu Met Ile Arg Glu Ala Phe Ala Glu
        995                 1000                1005            
Asp Ser Gly Arg Phe Thr Cys Ser Ala Val Asn Glu Ala Gly Thr Val
    1010                1015                1020                
Ser Thr Ser Cys Tyr Leu Ala Val Gln Val Ser Glu Glu Phe Glu Lys
1025                1030                1035                1040
Glu Thr Thr Ala Val Thr Glu Lys Phe Thr Thr Glu Glu Lys Arg Phe
                1045                1050                1055    
Val Glu Ser Arg Asp Val Val Met Thr Asp Thr Ser Leu Thr Glu Glu
            1060                1065                1070        
Gln Ala Gly Pro Gly Glu Pro Ala Ala Pro Tyr Phe Ile Thr Lys Pro
        1075                1080                1085            
Val Val Gln Lys Leu Val Glu Gly Gly Ser Val Val Phe Gly Cys Gln
    1090                1095                1100                
Val Gly Gly Asn Pro Lys Pro His Val Tyr Trp Lys Lys Ser Gly Val
1105                1110                1115                1120
Pro Leu Thr Thr Gly Tyr Arg Tyr Lys Val Ser Tyr Asn Lys Gln Thr
                1125                1130                1135    
Gly Glu Cys Lys Leu Val Ile Ser Met Thr Phe Ala Asp Asp Ala Gly
            1140                1145                1150        
Glu Tyr Thr Ile Val Val Arg Asn Lys His Gly Glu Thr Ser Ala Ser
        1155                1160                1165            
Ala Ser Leu Leu Glu Glu Ala Asp Tyr Glu Leu Leu Met Lys Ser Gln
    1170                1175                1180                
Gln Glu Met Leu Tyr Gln Thr Gln Val Thr Ala Phe Val Gln Glu Pro
1185                1190                1195                1200
Lys Val Gly Glu Thr Ala Pro Gly Phe Val Tyr Ser Glu Tyr Glu Lys
                1205                1210                1215    
Glu Tyr Glu Lys Glu Gln Ala Leu Ile Arg Lys Lys Met Ala Lys Asp
            1220                1225                1230        
Thr Val Val Val Arg Thr Tyr Val Glu Asp Gln Glu Phe His Ile Ser
        1235                1240                1245            
Ser Phe Glu Glu Arg Leu Ile Lys Glu Ile Glu Tyr Arg Ile Ile Lys
    1250                1255                1260                
Thr Thr Leu Glu Glu Leu Leu Glu Glu Asp Gly Glu Glu Lys Met Ala
1265                1270                1275                1280
Val Asp Ile Ser Glu Ser Glu Ala Val Glu Ser Gly Phe Asp Ser Arg
                1285                1290                1295    
Ile Lys Asn Tyr Arg Ile Leu Glu Gly Met Gly Val Thr Phe His Cys
            1300                1305                1310        
Lys Met Ser Gly Tyr Pro Leu Pro Lys Ile Ala Trp Tyr Lys Asp Gly
        1315                1320                1325            
Lys Arg Ile Lys His Gly Glu Arg Tyr Gln Met Asp Phe Leu Gln Asp
    1330                1335                1340                
Gly Arg Ala Ser Leu Arg Ile Pro Val Val Leu Pro Glu Asp Glu Gly
1345                1350                1355                1360
Ile Tyr Thr Ala Phe Ala Ser Asn Ile Lys Gly Asn Ala Ile Cys Ser
                1365                1370                1375    
Gly Lys Leu Tyr Val Glu Pro Ala Ala Pro Leu Gly Ala Pro Thr Tyr
            1380                1385                1390        
Ile Pro Thr Leu Glu Pro Val Ser Arg Ile Arg Ser Leu Ser Pro Arg
        1395                1400                1405            
Ser Val Ser Arg Ser Pro Ile Arg Met Ser Pro Ala Arg Met Ser Pro
    1410                1415                1420                
Ala Arg Met Ser Pro Ala Arg Met Ser Pro Ala Arg Met Ser Pro Gly
1425                1430                1435                1440
Arg Arg Leu Glu Glu Thr Asp Glu Ser Gln Leu Glu Arg Leu Tyr Lys
                1445                1450                1455    
Pro Val Phe Val Leu Lys Pro Val Ser Phe Lys Cys Leu Glu Gly Gln
            1460                1465                1470        
Thr Ala Arg Phe Asp Leu Lys Val Val Gly Arg Pro Met Pro Glu Thr
        1475                1480                1485            
Phe Trp Phe His Asp Gly Gln Gln Ile Val Asn Asp Tyr Thr His Lys
    1490                1495                1500                
Val Val Ile Lys Glu Asp Gly Thr Gln Ser Leu Ile Ile Val Pro Ala
1505                1510                1515                1520
Thr Pro Ser Asp Ser Gly Glu Trp Thr Val Val Ala Gln Asn Arg Ala
                1525                1530                1535    
Gly Arg Ser Ser Ile Ser Val Ile Leu Thr Val Glu Ala Val Glu His
            1540                1545                1550        
Gln Val Lys Pro Met Phe Val Glu Lys Leu Lys Asn Val Asn Ile Lys
        1555                1560                1565            
Glu Gly Ser Arg Leu Glu Met Lys Val Arg Ala Thr Gly Asn Pro Asn
    1570                1575                1580                
Pro Asp Ile Val Trp Leu Lys Asn Ser Asp Ile Ile Val Pro His Lys
1585                1590                1595                1600
Tyr Pro Lys Ile Arg Ile Glu Gly Thr Lys Gly Glu Ala Ala Leu Lys
                1605                1610                1615    
Ile Asp Ser Thr Val Ser Gln Asp Ser Ala Trp Tyr Thr Ala Thr Ala
            1620                1625                1630        
Ile Asn Lys Ala Gly Arg Asp Thr Thr Arg Cys Lys Val Asn Val Glu
        1635                1640                1645            
Val Glu Phe Ala Glu Pro Glu Pro Glu Arg Lys Leu Ile Ile Pro Arg
    1650                1655                1660                
Gly Thr Tyr Arg Ala Lys Glu Ile Ala Ala Pro Glu Leu Glu Pro Leu
1665                1670                1675                1680
His Leu Arg Tyr Gly Gln Glu Gln Trp Glu Glu Gly Asp Leu Tyr Asp
                1685                1690                1695    
Lys Glu Lys Gln Gln Lys Pro Phe Phe Lys Lys Lys Leu Thr Ser Leu
            1700                1705                1710        
Arg Leu Lys Arg Phe Gly Pro Ala His Phe Glu Cys Arg Leu Thr Pro
        1715                1720                1725            
Ile Gly Asp Pro Thr Met Val Val Glu Trp Leu His Asp Gly Lys Pro
    1730                1735                1740                
Leu Glu Ala Ala Asn Arg Leu Arg Met Ile Asn Glu Phe Gly Tyr Cys
1745                1750                1755                1760
Ser Leu Asp Tyr Gly Val Ala Tyr Ser Arg Asp Ser Gly Ile Ile Thr
                1765                1770                1775    
Cys Arg Ala Thr Asn Lys Tyr Gly Thr Asp His Thr Ser Ala Thr Leu
            1780                1785                1790        
Ile Val Lys Asp Glu Lys Ser Leu Val Glu Glu Ser Gln Leu Pro Glu
        1795                1800                1805            
Gly Arg Lys Gly Leu Gln Arg Ile Glu Glu Leu Glu Arg Met Ala His
    1810                1815                1820                
Glu Gly Ala Leu Thr Gly Val Thr Thr Asp Gln Lys Glu Lys Gln Lys
1825                1830                1835                1840
Pro Asp Ile Val Leu Tyr Pro Glu Pro Val Arg Val Leu Glu Gly Glu
                1845                1850                1855    
Thr Ala Arg Phe Arg Cys Arg Val Thr Gly Tyr Pro Gln Pro Lys Val
            1860                1865                1870        
Asn Trp Tyr Leu Asn Gly Gln Leu Ile Arg Lys Ser Lys Arg Phe Arg
        1875                1880                1885            
Val Arg Tyr Asp Gly Ile His Tyr Leu Asp Ile Val Asp Cys Lys Ser
    1890                1895                1900                
Tyr Asp Thr Gly Glu Val Lys Val Thr Ala Glu Asn Pro Glu Gly Val
1905                1910                1915                1920
Ile Glu His Lys Val Lys Leu Glu Ile Gln Gln Arg Glu Asp Phe Arg
                1925                1930                1935    
Ser Val Leu Arg Arg Ala Pro Glu Pro Arg Pro Glu Phe His Val His
            1940                1945                1950        
Glu Pro Gly Lys Leu Gln Phe Glu Val Gln Lys Val Asp Arg Pro Val
        1955                1960                1965            
Asp Thr Thr Glu Thr Lys Glu Val Val Lys Leu Lys Arg Ala Glu Arg
    1970                1975                1980                
Ile Thr His Glu Lys Val Pro Glu Glu Ser Glu Glu Leu Arg Ser Lys
1985                1990                1995                2000
Phe Lys Arg Arg Thr Glu Glu Gly Tyr Tyr Glu Ala Ile Thr Ala Val
                2005                2010                2015    
Glu Leu Lys Ser Arg Lys Lys Asp Glu Ser Tyr Glu Glu Leu Leu Arg
            2020                2025                2030        
Lys Thr Lys Asp Glu Leu Leu His Trp Thr Lys Glu Leu Thr Glu Glu
        2035                2040                2045            
Glu Lys Lys Ala Leu Ala Glu Glu Gly Lys Ile Thr Ile Pro Thr Phe
    2050                2055                2060                
Lys Pro Asp Lys Ile Glu Leu Ser Pro Ser Met Glu Ala Pro Lys Ile
2065                2070                2075                2080
Phe Glu Arg Ile Gln Ser Gln Thr Val Gly Gln Gly Ser Asp Ala His
                2085                2090                2095    
Phe Arg Val Arg Val Val Gly Lys Pro Asp Pro Glu Cys Glu Trp Tyr
            2100                2105                2110        
Lys Asn Gly Val Lys Ile Glu Arg Ser Asp Arg Ile Tyr Trp Tyr Trp
        2115                2120                2125            
Pro Glu Asp Asn Val Cys Glu Leu Val Ile Arg Asp Val Thr Ala Glu
    2130                2135                2140                
Asp Ser Ala Ser Ile Met Val Lys Ala Ile Asn Ile Ala Gly Glu Thr
2145                2150                2155                2160
Ser Ser His Ala Phe Leu Leu Val Gln Ala Lys Gln Leu Ile Thr Phe
                2165                2170                2175    
Thr Gln Glu Leu Gln Asp Val Val Ala Lys Glu Lys Asp Thr Met Ala
            2180                2185                2190        
Thr Phe Glu Cys Glu Thr Ser Glu Pro Phe Val Lys Val Lys Trp Tyr
        2195                2200                2205            
Lys Asp Gly Met Glu Val His Glu Gly Asp Lys Tyr Arg Met His Ser
    2210                2215                2220                
Asp Arg Lys Val His Phe Leu Ser Ile Leu Thr Ile Asp Thr Ser Asp
2225                2230                2235                2240
Ala Glu Asp Tyr Ser Cys Val Leu Val Glu Asp Glu Asn Val Lys Thr
                2245                2250                2255    
Thr Ala Lys Leu Ile Val Glu Gly Ala Val Val Glu Phe Val Lys Glu
            2260                2265                2270        
Leu Gln Asp Ile Glu Val Pro Glu Ser Tyr Ser Gly Glu Leu Glu Cys
        2275                2280                2285            
Ile Val Ser Pro Glu Asn Ile Glu Gly Lys Trp Tyr His Asn Asp Val
    2290                2295                2300                
Glu Leu Lys Ser Asn Gly Lys Tyr Thr Ile Thr Ser Arg Arg Gly Arg
2305                2310                2315                2320
Gln Asn Leu Thr Val Lys Asp Val Thr Lys Glu Asp Gln Gly Glu Tyr
                2325                2330                2335    
Ser Phe Val Ile Asp Gly Lys Lys Thr Thr Cys Lys Leu Lys Met Lys
            2340                2345                2350        
Pro Arg Pro Ile Ala Ile Leu Gln Gly Leu Ser Asp Gln Lys Val Cys
        2355                2360                2365            
Glu Gly Asp Ile Val Gln Leu Glu Val Lys Val Ser Leu Glu Ser Val
    2370                2375                2380                
Glu Gly Val Trp Met Lys Asp Gly Gln Glu Val Gln Pro Ser Asp Arg
2385                2390                2395                2400
Val His Ile Val Ile Asp Lys Gln Ser His Met Leu Leu Ile Glu Asp
                2405                2410                2415    
Met Thr Lys Glu Asp Ala Gly Asn Tyr Ser Phe Thr Ile Pro Ala Leu
            2420                2425                2430        
Gly Leu Ser Thr Ser Gly Arg Val Ser Val Tyr Ser Val Asp Val Ile
        2435                2440                2445            
Thr Pro Leu Lys Asp Val Asn Val Ile Glu Gly Thr Lys Ala Val Leu
    2450                2455                2460                
Glu Cys Lys Val Ser Val Pro Asp Val Thr Ser Val Lys Trp Tyr Leu
2465                2470                2475                2480
Asn Asp Glu Gln Ile Lys Pro Asp Asp Arg Val Gln Ala Ile Val Lys
                2485                2490                2495    
Gly Thr Lys Gln Arg Leu Val Ile Asn Arg Thr His Ala Ser Asp Glu
            2500                2505                2510        
Gly Pro Tyr Lys Leu Ile Val Gly Arg Val Glu Thr Asn Cys Asn Leu
        2515                2520                2525            
Ser Val Glu Lys Ile Lys Ile Ile Arg Gly Leu Arg Asp Leu Thr Cys
    2530                2535                2540                
Thr Glu Thr Gln Asn Val Val Phe Glu Val Glu Leu Ser His Ser Gly
2545                2550                2555                2560
Ile Asp Val Leu Trp Asn Phe Lys Asp Lys Glu Ile Lys Pro Ser Ser
                2565                2570                2575    
Lys Tyr Lys Ile Glu Ala His Gly Lys Ile Tyr Lys Leu Thr Val Leu
            2580                2585                2590        
Asn Met Met Lys Asp Asp Glu Gly Lys Tyr Thr Phe Tyr Ala Gly Glu
        2595                2600                2605            
Asn Met Thr Ser Gly Lys Leu Thr Val Ala Gly Gly Ala Ile Ser Lys
    2610                2615                2620                
Pro Leu Thr Asp Gln Thr Val Ala Glu Ser Gln Glu Ala Val Phe Glu
2625                2630                2635                2640
Cys Glu Val Ala Asn Pro Asp Ser Lys Gly Glu Trp Leu Arg Asp Gly
                2645                2650                2655    
Lys His Leu Pro Leu Thr Asn Asn Ile Arg Ser Glu Ser Asp Gly His
            2660                2665                2670        
Lys Arg Arg Leu Ile Ile Ala Ala Thr Lys Leu Asp Asp Ile Gly Glu
        2675                2680                2685            
Tyr Thr Tyr Lys Val Ala Thr Ser Lys Thr Ser Ala Lys Leu Lys Val
    2690                2695                2700                
Glu Gly Lys Val Thr Val Lys Ile Lys Lys Thr Leu Lys Asn Leu Thr
2705                2710                2715                2720
Val Thr Glu Thr Gln Asp Ala Val Phe Thr Val Glu Leu Thr His Pro
                2725                2730                2735    
Asn Val Lys Gly Val Gln Trp Ile Lys Asn Gly Val Val Leu Glu Ser
            2740                2745                2750        
Asn Glu Lys Tyr Ala Ile Ser Val Lys Gly Thr Ile Tyr Ser Leu Arg
        2755                2760                2765            
Ile Lys Asn Cys Ala Ile Val Asp Glu Ser Val Tyr Gly Phe Arg Leu
    2770                2775                2780                
Gly Arg Leu Gly Ala Ser Ala Arg Leu His Val Glu Thr Val Lys Ile
2785                2790                2795                2800
Ile Lys Lys Pro Lys Asp Val Thr Ala Leu Glu Asn Ala Thr Val Ala
                2805                2810                2815    
Phe Glu Val Ser Val Ser His Asp Thr Val Pro Val Lys Trp Phe His
            2820                2825                2830        
Lys Ser Val Glu Ile Lys Pro Ser Asp Lys His Arg Leu Val Ser Glu
        2835                2840                2845            
Arg Lys Val His Lys Leu Met Leu Gln Asn Ile Ser Pro Ser Asp Ala
    2850                2855                2860                
Gly Glu Tyr Thr Ala Val Val Gly Gln Leu Glu Cys Lys Ala Lys Leu
2865                2870                2875                2880
Phe Val Glu Thr Leu His Ile Thr Lys Thr Met Lys Asn Ile Glu Val
                2885                2890                2895    
Pro Glu Thr Lys Thr Ala Ser Phe Glu Cys Glu Val Ser His Phe Asn
            2900                2905                2910        
Val Pro Ser Met Trp Leu Lys Asn Gly Val Glu Ile Glu Met Ser Glu
        2915                2920                2925            
Lys Phe Lys Ile Val Val Gln Gly Lys Leu His Gln Leu Ile Ile Met
    2930                2935                2940                
Asn Thr Ser Thr Glu Asp Ser Ala Glu Tyr Thr Phe Val Cys Gly Asn
2945                2950                2955                2960
Asp Gln Val Ser Ala Thr Leu Thr Val Thr Pro Ile Met Ile Thr Ser
                2965                2970                2975    
Met Leu Lys Asp Ile Asn Ala Glu Glu Lys Asp Thr Ile Thr Phe Glu
            2980                2985                2990        
Val Thr Val Asn Tyr Glu Gly Ile Ser Tyr Lys Trp Leu Lys Asn Gly
        2995                3000                3005            
Val Glu Ile Lys Ser Thr Asp Lys Cys Gln Met Arg Thr Lys Lys Leu
    3010                3015                3020                
Thr His Ser Leu Asn Ile Arg Asn Val His Phe Gly Asp Ala Ala Asp
3025                3030                3035                3040
Tyr Thr Phe Val Ala Gly Lys Ala Thr Ser Thr Ala Thr Leu Tyr Val
                3045                3050                3055    
Glu Ala Arg His Ile Glu Phe Arg Lys His Ile Lys Asp Ile Lys Val
            3060                3065                3070        
Leu Glu Lys Lys Arg Ala Met Phe Glu Cys Glu Val Ser Glu Pro Asp
        3075                3080                3085            
Ile Thr Val Gln Trp Met Lys Asp Asp Gln Glu Leu Gln Ile Thr Asp
    3090                3095                3100                
Arg Ile Lys Ile Gln Lys Glu Lys Tyr Val His Arg Leu Leu Ile Pro
3105                3110                3115                3120
Ser Thr Arg Met Ser Asp Ala Gly Lys Tyr Thr Val Val Ala Gly Gly
                3125                3130                3135    
Asn Val Ser Thr Ala Lys Leu Phe Val Glu Gly Arg Asp Val Arg Ile
            3140                3145                3150        
Arg Ser Ile Lys Lys Glu Val Gln Val Ile Glu Lys Gln Arg Ala Val
        3155                3160                3165            
Val Glu Phe Glu Val Asn Glu Asp Asp Val Asp Ala His Trp Tyr Lys
    3170                3175                3180                
Asp Gly Ile Glu Ile Asn Phe Gln Val Gln Glu Arg His Lys Tyr Val
3185                3190                3195                3200
Val Glu Arg Arg Ile His Arg Met Phe Ile Ser Glu Thr Arg Gln Ser
                3205                3210                3215    
Asp Ala Gly Glu Tyr Thr Phe Val Ala Gly Arg Asn Arg Ser Ser Val
            3220                3225                3230        
Thr Leu Tyr Val Asn Ala Pro Glu Pro Pro Gln Val Leu Gln Glu Leu
        3235                3240                3245            
Gln Pro Val Thr Val Gln Ser Gly Lys Pro Ala Arg Phe Cys Ala Val
    3250                3255                3260                
Ile Ser Gly Arg Pro Gln Pro Lys Ile Ser Trp Tyr Lys Glu Glu Gln
3265                3270                3275                3280
Leu Leu Ser Thr Gly Phe Lys Cys Lys Phe Leu His Asp Gly Gln Glu
                3285                3290                3295    
Tyr Thr Leu Leu Leu Ile Glu Ala Phe Pro Glu Asp Ala Ala Val Tyr
            3300                3305                3310        
Thr Cys Glu Ala Lys Asn Asp Tyr Gly Val Ala Thr Thr Ser Ala Ser
        3315                3320                3325            
Leu Ser Val Glu Val Pro Glu Val Val Ser Pro Asp Gln Glu Met Pro
    3330                3335                3340                
Val Tyr Pro Pro Ala Ile Ile Thr Pro Leu Gln Asp Thr Val Thr Ser
3345                3350                3355                3360
Glu Gly Gln Pro Ala Arg Phe Gln Cys Arg Val Ser Gly Thr Asp Leu
                3365                3370                3375    
Lys Val Ser Trp Tyr Ser Lys Asp Lys Lys Ile Lys Pro Ser Arg Phe
            3380                3385                3390        
Phe Arg Met Thr Gln Phe Glu Asp Thr Tyr Gln Leu Glu Ile Ala Glu
        3395                3400                3405            
Ala Tyr Pro Glu Asp Glu Gly Thr Tyr Thr Phe Val Ala Ser Asn Ala
    3410                3415                3420                
Val Gly Gln Val Ser Ser Thr Ala Asn Leu Ser Leu Glu Ala Pro Glu
3425                3430                3435                3440
Ser Ile Leu His Glu Arg Ile Glu Gln Glu Ile Glu Met Glu Met Lys
                3445                3450                3455    
Glu Leu Phe Ser Glu Gly Glu Ser Glu His Ser Glu Arg Asp Thr Arg
            3460                3465                3470        
Asp Ala Phe Ser Asp Ser Glu Asp Ile Asp His Lys Ser Met Ala Ala
        3475                3480                3485            
Lys Arg Tyr Ala Ser Arg Ile Ser Ser Thr Ser Ser Trp Pro Glu Tyr
    3490                3495                3500                
Phe Lys Pro Ser Phe Thr Gln Lys Leu Thr Phe Lys Tyr Val Leu Glu
3505                3510                3515                3520
Gly Glu Pro Val Val Phe Thr Cys Arg Leu Ile Ala Cys Pro Thr Pro
                3525                3530                3535    
Glu Met Thr Trp Phe His Asn Asn Arg Pro Ile Pro Thr Gly Leu Arg
            3540                3545                3550        
Arg Ile Ile Lys Ala Glu Ser Asp Leu His His His Ser Ser Ser Leu
        3555                3560                3565            
Glu Ile Lys Arg Val Gln Asp Arg Asp Ser Gly Ser Tyr Arg Leu Leu
    3570                3575                3580                
Ala Ile Asn Ser Glu Gly Ser Ala Glu Ser Thr Ala Ser Leu Leu Val
3585                3590                3595                3600
Ile Gln Lys Gly Gln Asp Glu Lys Tyr Leu Glu Phe Leu Lys Arg Ala
                3605                3610                3615    
Glu Arg Thr His Glu Asn Val Glu Ala Leu Val Glu Arg Gly Glu Asp
            3620                3625                3630        
Arg Ile Lys Val Asp Leu Arg Phe Thr Gly Ser Pro Phe Asn Lys Lys
        3635                3640                3645            
Gln Asp Val Glu Gln Lys Gly Met Met Arg Thr Ile His Phe Lys Thr
    3650                3655                3660                
Met Ser Ser Ala Lys Lys Thr Asp Tyr Met Tyr Asp Glu Glu Tyr Leu
3665                3670                3675                3680
Glu Ser Lys Ser Asp Ile Arg Gly Trp Leu Asn Val Gly Glu Ser Phe
                3685                3690                3695    
Leu Asp Lys Glu Thr Lys Val Lys Leu Gln Arg Leu Arg Glu Ala Arg
            3700                3705                3710        
Lys Thr Leu Met Glu Lys Lys Lys Leu Ser Leu Leu Asp Thr Ser Ser
        3715                3720                3725            
Glu Ile Ser Ser Arg Thr Leu Arg Ser Glu Ala Ser Asp Lys Asp Ile
    3730                3735                3740                
Leu Phe Ser Arg Glu Asp Met Lys Ile Arg Ser Met Ser Asp Leu Ala
3745                3750                3755                3760
Glu Ser Tyr Lys Val Asp His Ser Ala Glu Ser Ile Val Gln Asn Pro
                3765                3770                3775    
His Ala Leu Ser Asn Gln Met Asp Gln Asn Ile Glu Ser Glu Glu Leu
            3780                3785                3790        
Pro Thr Ser Phe Gln Thr Ile Val Asp Glu Glu Ile Phe Gln Thr Glu
        3795                3800                3805            
Ile Arg Met Ser Gln Glu Ala Leu Val Lys Glu Ser Leu Pro Lys Asp
    3810                3815                3820                
His Leu Tyr Gly Glu Ile Leu Val Asn Glu Asn Thr Gln Ala Arg Gly
3825                3830                3835                3840
Gln Leu Glu Glu Ile Met Ala Asn Thr Thr Ile Gly Glu Ser Ser Thr
                3845                3850                3855    
Tyr Ile Thr Asn Val Cys Glu Lys Glu Glu Val Tyr Glu Thr Pro Glu
            3860                3865                3870        
Asn Val Ser Gln Ala Ile Thr Pro His Ala Ser Glu Ser Phe Gly Thr
        3875                3880                3885            
Leu Val Asn Val Glu Glu Ser Glu Glu Ile Ala Ser Glu Arg Ile Lys
    3890                3895                3900                
Lys Asp Asp Leu Arg Glu Leu Gln Leu Ser Ala Ser Thr Arg Ile Asp
3905                3910                3915                3920
Glu Phe Lys Thr Glu Gln Lys Glu Glu Asn Met Arg Phe Phe Glu Asn
                3925                3930                3935    
Ser Phe Arg Lys Arg Pro Gln Arg Cys Pro Pro Ser Phe Leu Gln Glu
            3940                3945                3950        
Ile Glu Ser Gln Glu Val Tyr Glu Gly Asp Ser Cys Asn Phe Val Cys
        3955                3960                3965            
His Phe Gln Gly Tyr Pro Gln Pro Ile Val Thr Trp Tyr Asn Asn Asp
    3970                3975                3980                
Met Pro Ile Pro Arg Asn Gln Asn Phe Ile Ile His Ser Leu Glu Asn
3985                3990                3995                4000
Tyr Ser Ile Leu Thr Leu Ser Ser Val His His Gln Asn Glu Gly Ser
                4005                4010                4015    
Ile Thr Cys Val Leu Phe Asn Gln Tyr Gly Thr Val Lys Thr Thr Ser
            4020                4025                4030        
Met Leu Lys Val Lys Ala Lys Gln Lys His Asp Val Lys Ala His Lys
        4035                4040                4045            
Val Pro Val Phe His Asp Tyr Leu Asp Glu Glu Glu Glu Leu Ala Leu
    4050                4055                4060                
Val Phe Asp Gln Ala Lys Gly Ala His Pro Ser Met Ser Gln Glu Gly
4065                4070                4075                4080
Gln Thr Asn Leu His Leu Leu Lys Thr Asn Pro Pro Val Pro Pro Ser
                4085                4090                4095    
Gly Asp Thr Glu Leu Leu Ser Phe Pro Val Glu Ile Gln Val Thr Ala
            4100                4105                4110        
Ala Thr Pro Ile Pro Glu Gln Asp Lys Glu Ser Lys Glu Val Phe Gln
        4115                4120                4125            
Thr Glu Glu Leu Glu Pro Lys Ala Met Pro Gln Asp Gln Val Thr Gln
    4130                4135                4140                
Ser Pro Lys His Arg Phe Val Phe Leu Ser Asp Ile Thr Asn Glu Pro
4145                4150                4155                4160
Pro Lys Met Leu Gln Glu Met Pro Lys His Ala Arg Cys Arg Glu Gly
                4165                4170                4175    
Asp Ser Ile Ile Leu Glu Cys Leu Ile Ser Gly Glu Pro Gln Pro Val
            4180                4185                4190        
Val Thr Trp Phe Gln Asn Gly Val Leu Leu Lys Gln Asn Gln Lys Phe
        4195                4200                4205            
Gln Phe Glu Glu Val Asn Cys Ser His Gln Leu Tyr Ile Lys Asp Val
    4210                4215                4220                
Asn Ser Gln Asp Ser Gly Lys Tyr Lys Cys Val Ala Glu Asn Asn Ser
4225                4230                4235                4240
Gly Ala Val Glu Ser Val Ser Asp Leu Thr Val Glu Pro Val Thr Tyr
                4245                4250                4255    
Arg Glu Asn Ser Gln Phe Glu Asn Ile Gly Glu Ile Tyr Gly Lys Tyr
            4260                4265                4270        
Ser Arg Asp Gln Gln Leu Gln Asp Gln Gly Glu Ser Val Arg Ala His
        4275                4280                4285            
Phe Tyr Asp Tyr Pro Ala Gly Pro Phe Thr Pro Trp Thr Asn Val Lys
    4290                4295                4300                
Glu Tyr Ser Val Arg Asp Tyr Phe Gln Ser Leu Glu Thr Ile Glu Gln
4305                4310                4315                4320
Ile Asp Gln Lys Glu Gln Val Arg Cys Ile Pro Ser Arg Glu Lys Ile
                4325                4330                4335    
Pro Arg Phe Val His Gly Ala Ser Arg Thr Ile Lys Ile Ser Lys Pro
            4340                4345                4350        
Ile Arg Ala Glu Phe Ile Gln Cys Gln Ala Glu Gly Lys Glu Arg His
        4355                4360                4365            
Val Ser Glu Lys Ser Lys Leu His Gln Ala Glu Gly Thr Val Tyr Pro
    4370                4375                4380                
Phe Val Asp Asp Phe Ser Asp Val Thr Ile Lys Lys Glu Ile Arg Asn
4385                4390                4395                4400
Asn Phe Gly Lys Leu Gly Arg Ser Glu Lys Glu Asn Val Gln Glu Cys
                4405                4410                4415    
Ala Gln Ser Asp Tyr Leu Pro Asn Ile His Ser Glu Arg Ile Ser Asp
            4420                4425                4430        
Ser Tyr Asn Thr Lys Asp Ser Ser Ala Ile Val Tyr Glu Glu Ser Leu
        4435                4440                4445            
Gly Glu Glu Ile His Tyr Pro Gly Lys Lys Val Lys His Arg Ile Ile
    4450                4455                4460                
Glu Phe Glu Lys Leu His Val Glu Lys Gly Val Leu Glu Lys Arg Pro
4465                4470                4475                4480
Thr Arg Thr Ser Ile Val Asn Pro Pro Gln Lys Lys Ile Asp Asp Lys
                4485                4490                4495    
Ala Phe Ser Leu Lys Gln Arg Glu Ser Arg Ser Ser Asn Leu Asn Ala
            4500                4505                4510        
Asn Met Tyr Gln Ala Glu Lys Met Ser Pro Asn Thr Glu Ser Asp Ser
        4515                4520                4525            
Ser Asn Ile Ala Ile Asn Leu Lys Leu Leu Ser Ser Gln Thr His Lys
    4530                4535                4540                
Glu Phe Asp Ala Gln Glu Arg Glu Gln Gln Glu Lys Ile Ser Leu Ile
4545                4550                4555                4560
Asp Lys Pro Ala Ile Ser Lys Arg Ala Glu His Glu Ser Pro Ile Thr
                4565                4570                4575    
Phe Asp Leu Lys Gln Phe His Thr Gln Ile Lys His Thr Asp Val Lys
            4580                4585                4590        
Phe Gln Glu Leu Asp Ser Gly Gln Pro Glu Glu Ala Tyr Phe Lys Ile
        4595                4600                4605            
Gln His Pro Ala Asp Thr Glu Asn Ile Val Phe Asp Leu Lys Gln Met
    4610                4615                4620                
Tyr Ser His Ile Gly Asp Pro Ala Leu Glu Phe Gln Gly Gln Glu Thr
4625                4630                4635                4640
Arg Glu Gln Gln Glu Ile His Tyr Lys Glu Lys Ile Pro Ser Pro Glu
                4645                4650                4655    
Thr Leu Gln Pro Asp Thr His Asn Ile Ser Lys Ser Val Gln Asn Asn
            4660                4665                4670        
Val Phe Ala Ser Gln Glu Ile Ser Ser Ser Gln Glu Leu Ser Asn Arg
        4675                4680                4685            
Thr Met Val Glu Lys Ser Ser Ile Asp Glu Asn Ser Ile Ser Leu Glu
    4690                4695                4700                
Lys Glu Val Arg His Val Gln Glu Gln Asn Leu Asp Ile Leu Lys Thr
4705                4710                4715                4720
Asp Leu Ser Leu Lys Ser Phe Ser Glu Glu Ile Tyr Ser Glu Ser Cys
                4725                4730                4735    
Ala Leu Leu Pro Thr Ser Ser Ala Asp Ile Glu Glu Thr Asp Leu Ser
            4740                4745                4750        
Glu Lys Ser Cys Pro Leu Glu Asn Gly Gly Arg Ser Ser Ile Ser His
        4755                4760                4765            
Leu Lys Lys Ala Ala Ser Glu Glu Lys Pro Leu Gly Val Gly Glu Met
    4770                4775                4780                
Glu Glu Glu Cys Thr Leu Glu Pro Glu Leu Ala Ala Phe Pro Lys Gln
4785                4790                4795                4800
Asp Gly Gly Thr Gln Glu Tyr Thr Asp Ala Thr Leu Glu Asp His Arg
                4805                4810                4815    
Gly Asp Val Gln Glu Ala Asp Thr Leu His Arg Gln Leu Ser Leu Ser
            4820                4825                4830        
Gln Cys Phe Pro Leu Leu Met Thr Glu Glu Gln Gln Asn Pro Gly Glu
        4835                4840                4845            
Gln Ile Ser Thr Asn Ile His Ala Ser Gly Glu Glu Lys Cys Tyr Glu
    4850                4855                4860                
Glu Val Gln Val Gln Asn Glu Ala Ser Phe Ser Thr Leu Glu Gly Glu
4865                4870                4875                4880
Met Ile Glu Thr Ser Phe Ser Gln Asn Ile Pro Lys Leu Asp Glu Ala
                4885                4890                4895    
His Thr Thr Glu Ala Ala Glu Ser Glu Thr Ser Leu Thr Gln Tyr Leu
            4900                4905                4910        
Leu Ala Ala Gly Lys Arg Glu Val Pro Glu Thr Lys Asp Thr Arg Asp
        4915                4920                4925            
Gln Ala Lys Leu Val Gln Ser Glu Ser Ile Thr Ser Met Glu Val Glu
    4930                4935                4940                
Glu Val Thr Phe Asn Thr Val Tyr Glu Tyr Tyr Asn Gln Lys Gln Glu
4945                4950                4955                4960
Ser Leu Gly Arg Pro Leu Ser Pro Glu Ser Asp Ile Ser Ile Gly Val
                4965                4970                4975    
Gly Ser Thr Thr Ser Glu Glu Ile Ser Glu Leu Asp Gln Phe Tyr Thr
            4980                4985                4990        
Pro Pro Ser Ser Val Glu Tyr Phe Glu Ser Pro Lys Ser Pro Asp Leu
        4995                5000                5005            
Tyr Phe Asn Pro Ser Asp Ile Thr Lys Gln Ser Ser Ile His Ser Gly
    5010                5015                5020                
Gly Glu Thr Val Glu Arg Tyr Ser Thr Pro Leu Gly Glu Val Ala Glu
5025                5030                5035                5040
Arg Tyr Ser Thr Pro Ser Glu Gly Glu Val Gly Glu Arg Tyr Ser Thr
                5045                5050                5055    
Pro Pro Gly Glu Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Thr
            5060                5065                5070        
Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr Ser
        5075                5080                5085            
Thr Pro Pro Gly Glu Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu
    5090                5095                5100                
Thr Leu Glu Arg Tyr Ser Thr Pro Pro Gly Glu Ala Leu Glu Arg Tyr
5105                5110                5115                5120
Ser Ile Pro Thr Gly Gly Pro Asn Pro Thr Gly Thr Phe Lys Thr Tyr
                5125                5130                5135    
Pro Ser Lys Ile Glu Arg Glu Asp Gly Thr Pro Asn Glu His Phe Tyr
            5140                5145                5150        
Thr Pro Thr Glu Glu Arg Gly Ser Ala Tyr Glu Ile Trp Arg Ser Asp
        5155                5160                5165            
Ser Phe Gly Thr Pro Asn Glu Ala Ile Glu Pro Lys Asp Asn Glu Met
    5170                5175                5180                
Pro Pro Ser Phe Ile Glu Pro Leu Thr Lys Arg Lys Val Tyr Glu Asn
5185                5190                5195                5200
Thr Thr Leu Gly Phe Ile Val Glu Val Glu Gly Leu Pro Val Pro Gly
                5205                5210                5215    
Val Lys Trp Tyr Arg Asn Lys Ser Leu Leu Glu Pro Asp Glu Arg Ile
            5220                5225                5230        
Lys Met Glu Arg Val Gly Asn Val Cys Ser Leu Glu Ile Ser Asn Ile
        5235                5240                5245            
Gln Lys Gly Glu Gly Gly Glu Tyr Met Cys His Ala Val Asn Ile Ile
    5250                5255                5260                
Gly Glu Ala Lys Ser Phe Ala Asn Val Asp Ile Met Pro Gln Glu Glu
5265                5270                5275                5280
Arg Val Val Ala Leu Pro Pro Pro Val Thr His Gln His Val Met Glu
                5285                5290                5295    
Phe Asp Leu Glu His Thr Thr Ser Ser Arg Thr Pro Ser Pro Gln Glu
            5300                5305                5310        
Ile Val Leu Glu Val Glu Leu Ser Glu Lys Asp Val Lys Glu Phe Glu
        5315                5320                5325            
Lys Gln Val Lys Ile Val Thr Val Pro Glu Phe Thr Pro Asp His Lys
    5330                5335                5340                
Ser Met Ile Val Ser Leu Asp Val Leu Pro Phe Asn Phe Val Asp Pro
5345                5350                5355                5360
Asn Met Asp Ser Arg Glu Gly Glu Asp Lys Glu Leu Lys Ile Asp Leu
                5365                5370                5375    
Glu Val Phe Glu Met Pro Pro Arg Phe Ile Met Pro Ile Cys Asp Phe
            5380                5385                5390        
Lys Ile Pro Glu Asn Ser Asp Ala Val Phe Lys Cys Ser Val Ile Gly
        5395                5400                5405            
Ile Pro Thr Pro Glu Val Lys Trp Tyr Lys Glu Tyr Met Cys Ile Glu
    5410                5415                5420                
Pro Asp Asn Ile Lys Tyr Val Ile Ser Glu Glu Lys Gly Ser His Thr
5425                5430                5435                5440
Leu Lys Ile Arg Asn Val Cys Leu Ser Asp Ser Ala Thr Tyr Arg Cys
                5445                5450                5455    
Arg Ala Val Asn Cys Val Gly Glu Ala Ile Cys Arg Gly Phe Leu Thr
            5460                5465                5470        
Met Gly Asp Ser Glu Ile Phe Ala Val Ile Ala Lys Lys Ser Lys Val
        5475                5480                5485            
Thr Leu Ser Ser Leu Met Glu Glu Leu Val Leu Lys Ser Asn Tyr Thr
    5490                5495                5500                
Asp Ser Phe Phe Glu Phe Gln Val Val Glu Gly Pro Pro Arg Phe Ile
5505                5510                5515                5520
Lys Gly Ile Ser Asp Cys Tyr Ala Pro Ile Gly Thr Ala Ala Tyr Phe
                5525                5530                5535    
Gln Cys Leu Val Arg Gly Ser Pro Arg Pro Thr Val Tyr Trp Tyr Lys
            5540                5545                5550        
Asp Gly Lys Leu Val Gln Gly Arg Arg Phe Thr Val Glu Glu Ser Gly
        5555                5560                5565            
Thr Gly Phe His Asn Leu Phe Ile Thr Ser Leu Val Lys Ser Asp Glu
    5570                5575                5580                
Gly Glu Tyr Arg Cys Val Ala Thr Asn Lys Ser Gly Met Ala Glu Ser
5585                5590                5595                5600
Phe Ala Ala Leu Thr Leu Thr
                5605        


<210> 7938
<211> 518
<212> PRT
<213> Homo sapiens

<400> 7938
Met Leu Arg Val Val Ser Trp Asn Ile Asn Gly Ile Arg Arg Pro Leu
 1               5                  10                  15      
Gln Gly Val Ala Asn Gln Glu Pro Ser Asn Cys Ala Ala Val Ala Val
            20                  25                  30          
Gly Arg Ile Leu Asp Glu Leu Asp Ala Asp Ile Val Cys Leu Gln Glu
        35                  40                  45              
Thr Lys Val Thr Arg Asp Ala Leu Thr Glu Pro Leu Ala Ile Val Glu
    50                  55                  60                  
Gly Tyr Asn Ser Tyr Phe Ser Phe Ser Arg Asn Arg Ser Gly Tyr Ser
65                  70                  75                  80  
Gly Val Ala Thr Phe Cys Lys Asp Asn Ala Thr Pro Val Ala Ala Glu
                85                  90                  95      
Glu Gly Leu Ser Gly Leu Phe Ala Thr Gln Asn Gly Asp Val Gly Cys
            100                 105                 110         
Tyr Gly Asn Met Asp Glu Phe Thr Gln Glu Glu Leu Arg Ala Leu Asp
        115                 120                 125             
Ser Glu Gly Arg Ala Leu Leu Thr Gln His Lys Ile Arg Thr Trp Glu
    130                 135                 140                 
Gly Lys Glu Lys Thr Leu Thr Leu Ile Asn Val Tyr Cys Pro His Ala
145                 150                 155                 160 
Asp Pro Gly Arg Pro Glu Arg Leu Val Phe Lys Met Arg Phe Tyr Arg
                165                 170                 175     
Leu Leu Gln Ile Arg Ala Glu Ala Leu Leu Ala Ala Gly Ser His Val
            180                 185                 190         
Ile Ile Leu Gly Asp Leu Asn Thr Ala His Arg Pro Ile Asp His Trp
        195                 200                 205             
Asp Ala Val Asn Leu Glu Cys Phe Glu Glu Asp Pro Gly Arg Lys Trp
    210                 215                 220                 
Met Asp Ser Leu Leu Ser Asn Leu Gly Cys Gln Ser Ala Ser His Val
225                 230                 235                 240 
Gly Pro Phe Ile Asp Ser Tyr Arg Cys Phe Gln Pro Lys Gln Glu Gly
                245                 250                 255     
Ala Phe Thr Cys Trp Ser Ala Val Thr Gly Ala Arg His Leu Asn Tyr
            260                 265                 270         
Gly Ser Arg Leu Asp Tyr Val Leu Gly Asp Arg Thr Leu Val Ile Asp
        275                 280                 285             
Thr Phe Gln Ala Ser Phe Leu Leu Pro Glu Val Met Gly Ser Asp His
    290                 295                 300                 
Cys Pro Val Gly Ala Val Leu Ser Val Ser Ser Val Pro Ala Lys Gln
305                 310                 315                 320 
Cys Pro Pro Leu Cys Thr Arg Phe Leu Pro Glu Phe Ala Gly Thr Gln
                325                 330                 335     
Leu Lys Ile Leu Arg Phe Leu Val Pro Leu Glu Gln Ser Pro Val Leu
            340                 345                 350         
Glu Gln Ser Thr Leu Gln His Asn Asn Gln Thr Arg Val Gln Thr Cys
        355                 360                 365             
Gln Asn Lys Ala Gln Val Arg Ser Thr Arg Pro Gln Pro Ser Gln Val
    370                 375                 380                 
Gly Ser Ser Arg Gly Gln Lys Asn Leu Lys Ser Tyr Phe Gln Pro Ser
385                 390                 395                 400 
Pro Ser Cys Pro Gln Ala Ser Pro Asp Ile Glu Leu Pro Ser Leu Pro
                405                 410                 415     
Leu Met Ser Ala Leu Met Thr Pro Lys Thr Pro Glu Glu Lys Ala Val
            420                 425                 430         
Ala Lys Val Val Lys Gly Gln Ala Lys Thr Ser Glu Ala Lys Asp Glu
        435                 440                 445             
Lys Glu Leu Arg Thr Ser Phe Trp Lys Ser Val Leu Ala Gly Pro Leu
    450                 455                 460                 
Arg Thr Pro Leu Cys Gly Gly His Arg Glu Pro Cys Val Met Arg Thr
465                 470                 475                 480 
Val Lys Lys Pro Gly Pro Asn Leu Gly Arg Arg Phe Tyr Met Cys Ala
                485                 490                 495     
Arg Pro Arg Gly Pro Pro Thr Asp Pro Ser Ser Arg Cys Asn Phe Phe
            500                 505                 510         
Leu Trp Ser Arg Pro Ser
        515             


<210> 7939
<211> 252
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 175
<223> Xaa = Any Amino Acid

<400> 7939
Met Leu Leu Trp Ser His Asp Cys Ser His Glu Met Gln His Thr Phe
 1               5                  10                  15      
Leu Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Pro Asp Asn Gln Pro
            20                  25                  30          
Asp Val Leu Ile Gln Val Tyr Glu Gly Glu Ser Ala Ile Thr Lys Asp
        35                  40                  45              
Asn Asn Leu Leu Val Ile Gln Gly Lys Phe Glu Leu Thr Gly Ile Leu
    50                  55                  60                  
Pro Ala Pro Phe Ala Val Pro Gln Ile Lys Val Thr Cys Asp Ile Asp
65                  70                  75                  80  
Val Asn Ser Ser Leu Asn Ile Ser Ala Val Gly Lys Ser Thr Glu Lys
                85                  90                  95      
Glu Asn Lys Ile Ile Ile Thr Asn Asp Gln Gly His Leu Ser Lys Glu
            100                 105                 110         
Asp Ile Glu Asn Met Val Gln Glu Ala Glu Tyr Lys Ala Glu Asp Glu
        115                 120                 125             
Lys Gln Lys Asn Lys Val Ala Ser Lys Asn Ser Leu Asp Ser Tyr Ala
    130                 135                 140                 
Phe Asn Met Lys Ala Thr Glu Lys Leu Gln Gly Lys Ile Asn Asn Lys
145                 150                 155                 160 
Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Lys Ile Ile Asn Xaa Leu
                165                 170                 175     
Asp Lys Asn Gln Thr Ile Met Lys Glu Glu Phe Glu His Gln Gln Lys
            180                 185                 190         
Glu Leu Val Cys Ser Pro Ser Leu Ser Ser Cys Thr Arg Val Gln Gly
        195                 200                 205             
His Thr Arg Arg Asn Tyr Gln Ala Ile Leu Gly Tyr Arg Asp Met Leu
    210                 215                 220                 
Gly Gly Met Pro Glu Gly Phe Pro Gly Gly Arg Ala Pro Phe Ser Gly
225                 230                 235                 240 
Ser Ala Ser Leu Arg Pro Ile Ile Glu Glu Val Asp
                245                 250         


<210> 7940
<211> 169
<212> PRT
<213> Homo sapiens

<400> 7940
Met Val Pro Glu Arg Leu Pro Pro Trp Leu Gln Arg Tyr Val Asp Lys
 1               5                  10                  15      
Val Ser Asn Leu Ser Leu Phe Gly Gly Leu Pro Ala Asn His Val Leu
            20                  25                  30          
Val Asn Gln Tyr Leu Pro Gly Glu Gly Ile Met Pro His Glu Asp Gly
        35                  40                  45              
Pro Leu Tyr Tyr Pro Thr Val Ser Thr Ile Ser Leu Gly Ser His Thr
    50                  55                  60                  
Val Leu Asp Phe Tyr Glu Pro Arg Arg Pro Glu Asp Asp Asp Pro Thr
65                  70                  75                  80  
Glu Gln Pro Arg Pro Pro Pro Arg Pro Thr Thr Ser Leu Leu Leu Glu
                85                  90                  95      
Pro Arg Ser Leu Leu Val Leu Arg Gly Pro Ala Tyr Thr Arg Leu Leu
            100                 105                 110         
His Gly Ile Ala Ala Ala Arg Val Asp Ala Leu Asp Ala Ala Ser Ser
        115                 120                 125             
Pro Pro Asn Ala Ala Ala Cys Pro Ser Ala Arg Pro Gly Ala Cys Leu
    130                 135                 140                 
Val Arg Gly Thr Arg Val Ser Leu Thr Ile Arg Arg Val Pro Arg Val
145                 150                 155                 160 
Leu Arg Ala Gly Leu Leu Leu Gly Lys
                165                 


<210> 7941
<211> 538
<212> PRT
<213> Homo sapiens

<400> 7941
Met Ala Glu Asn Leu Lys Arg Leu Val Ser Asn Glu Thr Leu Arg Thr
 1               5                  10                  15      
Leu Gln Glu Lys Leu Asp Phe Trp Leu Lys Glu Tyr Asn Thr Asn Thr
            20                  25                  30          
Cys Asp Gln Asn Leu Asn His Cys Leu Glu Leu Ile Glu Gln Val Ala
        35                  40                  45              
Lys Val Gln Gly Gln Leu Phe Gly Ile Leu Thr Ala Ala Ala Gln Glu
    50                  55                  60                  
Gly Gly Arg Asn Asp Gly Val Glu Thr Ile Lys Ser Arg Leu Leu Pro
65                  70                  75                  80  
Trp Leu Glu Ala Ser Phe Thr Ala Ala Ser Leu Gly Lys Ser Val Asp
                85                  90                  95      
Ser Lys Val Pro Ser Leu Gln Asp Thr Phe Asp Arg Glu Arg His Lys
            100                 105                 110         
Asp Pro Ser Pro Arg Asp Arg Asp Met Gln Gln Leu Asp Ser Asn Leu
        115                 120                 125             
Asn Ser Thr Arg Ser Gln Cys Asn Gln Val Gln Asp Asp Leu Val Glu
    130                 135                 140                 
Thr Glu Lys Asn Leu Glu Glu Ser Lys Asn Arg Ser Ala Ile Ser Leu
145                 150                 155                 160 
Leu Ala Ala Glu Glu Glu Ile Asn Gln Leu Lys Lys Gln Leu Lys Ser
                165                 170                 175     
Leu Gln Ala Gln Glu Asp Ala Arg His Arg Asn Thr Asp Gln Arg Ser
            180                 185                 190         
Ser Glu Asn Arg Arg Ser Glu Pro Trp Ser Leu Glu Glu Arg Lys Arg
        195                 200                 205             
Glu Gln Trp Asn Ser Leu Lys Gln Asn Ala Asp Gln Gln Asp Thr Glu
    210                 215                 220                 
Ala Met Ser Asp Tyr Lys Lys Gln Leu Arg Asn Leu Lys Glu Glu Ile
225                 230                 235                 240 
Ala Val Leu Ser Ala Glu Lys Ser Ala Leu Gln Gly Arg Ser Ser Arg
                245                 250                 255     
Ser Arg Ser Pro Ser Pro Ala Pro Arg Ser Arg Ser Cys Ser Arg Ser
            260                 265                 270         
Arg Ser Ala Ser Pro Ser Thr Ala Val Lys Val Arg Arg Pro Ser Pro
        275                 280                 285             
Asn Arg Ser Lys Leu Ser Asn Val Ala Arg Lys Ala Ala Leu Leu Ser
    290                 295                 300                 
Arg Phe Ser Asp Ser Tyr Ser Gln Ala Arg Leu Asp Ala Gln Cys Leu
305                 310                 315                 320 
Leu Arg Arg Cys Ile Asp Lys Ala Glu Thr Val Gln Arg Ile Ile Tyr
                325                 330                 335     
Ile Ala Thr Val Glu Ala Phe His Val Ala Lys Met Ala Phe Arg His
            340                 345                 350         
Phe Lys Ile His Val Arg Lys Ser Leu Thr Pro Ser Tyr Val Gly Ser
        355                 360                 365             
Asn Asp Phe Glu Asn Ala Val Leu Asp Tyr Val Ile Cys His Leu Asp
    370                 375                 380                 
Leu Tyr Asp Ser Gln Ser Ser Val Asn Asp Val Ile Arg Ala Met Asn
385                 390                 395                 400 
Val Asn Pro Lys Ile Ser Phe Pro Pro Val Val Asp Phe Cys Leu Leu
                405                 410                 415     
Ser Asp Phe Ile Gln Glu Ile Cys Cys Ile Ala Phe Ala Met Gln Ala
            420                 425                 430         
Leu Glu Pro Pro Leu Asp Ile Ala Tyr Gly Ala Asp Gly Glu Val Phe
        435                 440                 445             
Asn Asp Cys Lys Tyr Arg Arg Ser Tyr Asp Ser Asp Phe Thr Ala Pro
    450                 455                 460                 
Leu Val Leu Tyr His Val Trp Pro Ala Leu Met Glu Asn Asp Cys Val
465                 470                 475                 480 
Ile Met Lys Gly Glu Ala Val Thr Arg Arg Gly Ala Phe Trp Asn Ser
                485                 490                 495     
Val Arg Ser Val Ser Arg Cys Arg Ser Arg Ser Leu Ser Pro Ile Cys
            500                 505                 510         
Pro Arg Ser Gln Ile Gly Leu Asn Thr Met Ser Arg Ser Arg Ser Pro
        515                 520                 525             
Ser Pro Ile Arg Cys Gly Leu Pro Arg Phe
    530                 535             


<210> 7942
<211> 522
<212> PRT
<213> Homo sapiens

<400> 7942
Met Ala Glu Asn Leu Lys Arg Leu Val Ser Asn Glu Thr Leu Arg Thr
 1               5                  10                  15      
Leu Gln Glu Lys Leu Asp Phe Trp Leu Lys Glu Tyr Asn Thr Asn Thr
            20                  25                  30          
Cys Asp Gln Asn Leu Asn His Cys Leu Glu Leu Ile Glu Gln Val Ala
        35                  40                  45              
Lys Val Gln Gly Gln Leu Phe Gly Ile Leu Thr Ala Ala Ala Gln Glu
    50                  55                  60                  
Gly Gly Arg Asn Asp Gly Val Glu Thr Ile Lys Ser Arg Leu Leu Pro
65                  70                  75                  80  
Trp Leu Glu Ala Ser Phe Thr Ala Ala Ser Leu Gly Lys Ser Val Asp
                85                  90                  95      
Ser Lys Val Pro Ser Leu Gln Asp Thr Phe Asp Arg Glu Arg His Lys
            100                 105                 110         
Asp Pro Ser Pro Arg Asp Arg Asp Met Gln Gln Leu Asp Ser Asn Leu
        115                 120                 125             
Asn Ser Thr Arg Ser Gln Cys Asn Gln Val Gln Asp Asp Leu Val Glu
    130                 135                 140                 
Thr Glu Lys Asn Leu Glu Glu Ser Lys Asn Arg Ser Ala Ile Ser Leu
145                 150                 155                 160 
Leu Ala Ala Glu Glu Glu Ile Asn Gln Leu Lys Lys Gln Leu Lys Ser
                165                 170                 175     
Leu Gln Ala Gln Glu Asp Ala Arg His Arg Asn Thr Asp Gln Arg Ser
            180                 185                 190         
Ser Glu Asn Arg Arg Ser Glu Pro Trp Ser Leu Glu Glu Arg Lys Arg
        195                 200                 205             
Glu Gln Trp Asn Ser Leu Lys Gln Asn Ala Asp Gln Gln Asp Thr Glu
    210                 215                 220                 
Ala Met Pro Asp Tyr Lys Lys Gln Leu Arg Asn Leu Lys Glu Glu Ile
225                 230                 235                 240 
Ala Val Leu Ser Ala Glu Lys Ser Ala Leu Gln Gly Arg Ser Ser Arg
                245                 250                 255     
Ser Arg Ser Pro Ser Pro Ala Pro Arg Ser Arg Ser Cys Ser Arg Ser
            260                 265                 270         
Arg Ser Ala Ser Pro Ser Thr Ala Val Lys Val Arg Arg Pro Ser Pro
        275                 280                 285             
Asn Arg Ser Lys Leu Ser Asn Val Ala Arg Lys Ala Ala Leu Leu Ser
    290                 295                 300                 
Arg Phe Ser Asp Ser Tyr Ser Gln Ala Arg Leu Asp Ala Gln Cys Leu
305                 310                 315                 320 
Leu Arg Arg Cys Ile Asp Lys Ala Glu Thr Val Gln Arg Ile Ile Tyr
                325                 330                 335     
Ile Ala Thr Val Glu Ala Phe His Val Ala Lys Met Ala Phe Arg His
            340                 345                 350         
Phe Lys Ile His Val Arg Lys Ser Leu Thr Pro Ser Tyr Val Gly Ser
        355                 360                 365             
Asn Asp Phe Glu Asn Ala Val Leu Asp Tyr Val Ile Cys His Leu Asp
    370                 375                 380                 
Leu Tyr Asp Ser Gln Ser Ser Val Asn Asp Val Ile Arg Ala Met Asn
385                 390                 395                 400 
Val Asn Pro Lys Ile Ser Phe Pro Pro Val Val Asp Phe Cys Leu Leu
                405                 410                 415     
Ser Asp Phe Ile Gln Glu Ile Cys Cys Ile Ala Phe Ala Met Gln Ala
            420                 425                 430         
Leu Glu Pro Pro Leu Asp Ile Ala Tyr Gly Ala Asp Gly Glu Val Phe
        435                 440                 445             
Asn Asp Cys Lys Tyr Arg Arg Ser Tyr Asp Ser Asp Phe Thr Ala Pro
    450                 455                 460                 
Leu Val Leu Tyr His Val Trp Pro Ala Leu Met Glu Asn Asp Cys Val
465                 470                 475                 480 
Ile Met Lys Gly Glu Ala Val Thr Arg Arg Gly Ala Phe Val Arg Trp
                485                 490                 495     
Pro Cys Ile Val Thr Ile His Pro Lys Cys Leu Ile His Lys Phe Glu
            500                 505                 510         
Asn Ile Tyr Lys Pro Arg Asp Ser Ile Lys
        515                 520         


<210> 7943
<211> 502
<212> PRT
<213> Homo sapiens

<400> 7943
Met Phe Leu Glu Asn Glu Thr Trp Glu Leu Cys Pro Val Lys Ser Asn
 1               5                  10                  15      
Phe Ser Ile Leu Gln Leu His Glu Phe Lys Phe Met Glu Gln Ser Arg
            20                  25                  30          
Ser Pro Ser Val Ser Pro Ser Lys Gln Pro Val Ser Thr Ser Ser Lys
        35                  40                  45              
Thr Val Thr Leu Phe Glu Gln Tyr Cys Ser Gly Gly Asn Pro Phe Glu
    50                  55                  60                  
Ile Gln Ala Asn His Lys Asp Glu Glu Thr Glu Asp Val Leu Ala Ser
65                  70                  75                  80  
Asn Gly Tyr Glu Ser Asp Glu Gln Glu Lys Ser Ala Tyr Gln Glu Tyr
                85                  90                  95      
Asp Ser Asp Ser Asp Val Pro Glu Glu Leu Lys Arg Asp Tyr Val Asp
            100                 105                 110         
Glu Gln Thr Gly Asp Gly Pro Val Lys Ser Val Ser Arg Glu Thr Leu
        115                 120                 125             
Lys Ser Arg Lys Lys Ser Asp Tyr Ser Leu Asn Lys Val Asn Ala Pro
    130                 135                 140                 
Ile Leu Thr Asn Thr Thr Leu Asn Val Ile Arg Leu Val Gly Lys Tyr
145                 150                 155                 160 
Met Gln Met Met Asn Ile Leu Lys Pro Ile Ala Phe Asp Val Ile His
                165                 170                 175     
Phe Met Ser Gln Leu Phe Asp Tyr Tyr Leu Tyr Ala Ile Tyr Thr Phe
            180                 185                 190         
Phe Gly Arg Asn Asp Ser Leu Glu Ser Thr Gly Leu Gly Leu Ser Ser
        195                 200                 205             
Arg Leu Arg Thr Thr Leu Asn Arg Ile Gln Glu Ser Leu Ile Asp Leu
    210                 215                 220                 
Glu Val Ser Ala Asp Pro Thr Ala Thr Leu Thr Ala Ala Glu Glu Arg
225                 230                 235                 240 
Lys Glu Lys Val Pro Ser Pro His Leu Ser His Leu Val Val Leu Thr
                245                 250                 255     
Ser Gly Asp Thr Leu Tyr Gly Leu Ala Glu Arg Val Val Ala Thr Glu
            260                 265                 270         
Ser Leu Val Phe Leu Ala Glu Gln Phe Glu Phe Leu Gln Pro His Leu
        275                 280                 285             
Asp Ala Val Met Pro Ala Val Lys Lys Pro Phe Leu Gln Gln Phe Tyr
    290                 295                 300                 
Ser Gln Thr Val Ser Thr Ala Ser Glu Leu Arg Lys Pro Ile Tyr Trp
305                 310                 315                 320 
Ile Val Ala Gly Lys Ala Leu Asp Tyr Glu Gln Met Leu Leu Leu Met
                325                 330                 335     
Ala Asn Val Lys Trp Asp Val Lys Glu Ile Met Ser Gln Tyr Asn Ile
            340                 345                 350         
Tyr Val Asp Ala Leu Leu Lys Glu Phe Glu Gln Phe Asn Arg Arg Leu
        355                 360                 365             
Asn Glu Val Ser Lys Arg Val Arg Ile Pro Leu Pro Val Ser Asn Ile
    370                 375                 380                 
Leu Trp Glu His Cys Ile Arg Leu Ala Asn Arg Thr Ile Val Glu Gly
385                 390                 395                 400 
Tyr Ala Asn Val Lys Lys Cys Ser Asn Glu Gly Arg Ala Leu Met Gln
                405                 410                 415     
Leu Asp Phe Gln Gln Phe Leu Met Lys Leu Glu Lys Leu Thr Asp Ile
            420                 425                 430         
Arg Pro Ile Pro Asp Lys Glu Phe Val Glu Thr Tyr Ile Lys Ala Tyr
        435                 440                 445             
Tyr Leu Thr Glu Asn Asp Met Glu Arg Trp Ile Lys Glu His Arg Lys
    450                 455                 460                 
Tyr Ser Thr Lys Gln Leu Thr Asn Leu Val Asn Val Cys Leu Gly Ser
465                 470                 475                 480 
His Ile Asn Lys Lys Ala Arg Gln Lys Leu Leu Ala Ala Ile Asp Asp
                485                 490                 495     
Ile Asp Arg Pro Lys Arg
            500         


<210> 7944
<211> 557
<212> PRT
<213> Homo sapiens

<400> 7944
Leu Phe Ile Val His Phe Cys Arg His Leu Asn Ile Ala Lys Glu Gly
 1               5                  10                  15      
Phe Thr Gln Ala Ser Leu Gly Leu Leu Ala Asn Gln Arg Lys Arg Gln
            20                  25                  30          
Leu Leu Ile Gly Leu Leu Lys Ser Leu Arg Thr Ile Lys Thr Leu Gln
        35                  40                  45              
Arg Thr Asp Val Arg Leu Ser Glu Met Leu Glu Glu Glu Asp Tyr Pro
    50                  55                  60                  
Gly Ala Ile Gln Leu Cys Leu Glu Cys Gln Lys Ala Ala Ser Thr Phe
65                  70                  75                  80  
Lys His Tyr Ser Cys Ile Ser Glu Leu Asn Ser Lys Leu Gln Asp Thr
                85                  90                  95      
Leu Glu Gln Ile Glu Glu Gln Leu Asp Val Ala Leu Ser Lys Ile Cys
            100                 105                 110         
Lys Asn Phe Asp Ile Asn His Tyr Thr Lys Val Gln Gln Ala Tyr Arg
        115                 120                 125             
Leu Leu Gly Lys Thr Gln Thr Ala Met Asp Gln Leu His Met His Phe
    130                 135                 140                 
Thr Gln Ala Ile His Asn Thr Val Phe Gln Val Val Leu Gly Tyr Val
145                 150                 155                 160 
Glu Leu Cys Ala Gly Asn Thr Asp Thr Lys Phe Gln Lys Leu Gln Tyr
                165                 170                 175     
Lys Asp Leu Cys Thr His Val Thr Pro Asp Ser Tyr Ile Pro Cys Leu
            180                 185                 190         
Ala Asp Leu Cys Lys Ala Leu Trp Glu Val Met Leu Ser Tyr Tyr Arg
        195                 200                 205             
Thr Met Glu Trp His Glu Lys His Asp Asn Glu Asp Thr Ala Ser Ala
    210                 215                 220                 
Ser Glu Gly Ser Asn Met Ile Gly Thr Glu Glu Thr Asn Phe Asp Arg
225                 230                 235                 240 
Gly Tyr Ile Lys Lys Lys Leu Glu His Gly Leu Thr Arg Ile Trp Gln
                245                 250                 255     
Asp Val Gln Leu Lys Val Lys Thr Tyr Leu Leu Gly Thr Asp Leu Ser
            260                 265                 270         
Ile Phe Lys Tyr Asp Asp Phe Ile Phe Val Leu Asp Ile Ile Ser Arg
        275                 280                 285             
Leu Met Gln Val Gly Glu Glu Phe Cys Gly Ser Lys Ser Glu Val Leu
    290                 295                 300                 
Gln Glu Ser Ile Arg Lys Gln Ser Val Asn Tyr Phe Lys Asn Tyr His
305                 310                 315                 320 
Arg Thr Arg Leu Asp Glu Leu Arg Met Phe Leu Glu Asn Glu Thr Trp
                325                 330                 335     
Glu Leu Cys Pro Val Lys Ser Asn Phe Ser Ile Leu Gln Leu His Glu
            340                 345                 350         
Phe Lys Phe Met Glu Gln Ser Arg Ser Pro Ser Val Ser Pro Ser Lys
        355                 360                 365             
Gln Pro Val Ser Thr Ser Ser Lys Thr Val Thr Leu Phe Glu Gln Tyr
    370                 375                 380                 
Cys Ser Gly Gly Asn Pro Phe Glu Ile Gln Ala Asn His Lys Asp Glu
385                 390                 395                 400 
Glu Thr Glu Asp Val Leu Ala Ser Asn Gly Tyr Glu Ser Asp Glu Gln
                405                 410                 415     
Glu Lys Ser Ala Tyr Gln Glu Tyr Asp Ser Asp Ser Asp Val Pro Glu
            420                 425                 430         
Glu Leu Lys Arg Asp Tyr Val Asp Glu Gln Thr Gly Asp Gly Pro Val
        435                 440                 445             
Lys Ser Val Ser Arg Glu Thr Leu Lys Ser Arg Lys Lys Ser Asp Tyr
    450                 455                 460                 
Ser Leu Asn Lys Val Asn Ala Pro Ile Leu Thr Asn Thr Thr Leu Asn
465                 470                 475                 480 
Val Ile Arg Leu Val Gly Lys Tyr Met Gln Met Met Asn Ile Leu Lys
                485                 490                 495     
Pro Ile Ala Phe Asp Val Ile His Phe Met Ser Gln Leu Phe Asp Tyr
            500                 505                 510         
Tyr Leu Tyr Ala Ile Tyr Thr Phe Phe Gly Arg Asn Asp Ser Leu Glu
        515                 520                 525             
Ser Thr Gly Leu Gly Leu Ser Ser Ser Arg Leu Arg Thr Thr Leu Asn
    530                 535                 540                 
Arg Ile Gln Glu Ser Leu Ile Asp Leu Asp Met Phe Ile
545                 550                 555         


<210> 7945
<211> 413
<212> PRT
<213> Homo sapiens

<400> 7945
Met Asp Gln Leu His Met His Phe Thr Gln Ala Ile His Asn Thr Val
 1               5                  10                  15      
Phe Gln Val Val Leu Gly Tyr Val Glu Leu Cys Ala Gly Asn Thr Asp
            20                  25                  30          
Thr Lys Phe Gln Lys Leu Gln Tyr Lys Asp Leu Cys Thr His Val Thr
        35                  40                  45              
Pro Asp Ser Tyr Ile Pro Cys Leu Ala Asp Leu Cys Lys Ala Leu Trp
    50                  55                  60                  
Glu Val Met Leu Ser Tyr Tyr Arg Thr Met Glu Trp His Gly Lys His
65                  70                  75                  80  
Asp Asn Glu Asp Thr Ala Ser Ala Ser Glu Gly Ser Asn Met Ile Gly
                85                  90                  95      
Thr Glu Glu Thr Asn Phe Asp Arg Gly Tyr Ile Lys Lys Lys Leu Glu
            100                 105                 110         
His Gly Leu Thr Arg Ile Trp Gln Asp Val Gln Leu Lys Val Lys Thr
        115                 120                 125             
Tyr Leu Leu Gly Thr Asp Leu Ser Ile Phe Lys Tyr Asp Asp Phe Ile
    130                 135                 140                 
Phe Val Leu Asp Ile Ile Ser Arg Leu Met Gln Val Gly Glu Glu Phe
145                 150                 155                 160 
Cys Gly Ser Lys Ser Glu Val Leu Gln Glu Ser Ile Arg Lys Gln Ser
                165                 170                 175     
Val Asn Tyr Phe Lys Asn Tyr His Arg Thr Arg Leu Asp Glu Leu Arg
            180                 185                 190         
Met Phe Leu Glu Asn Glu Thr Trp Glu Leu Cys Pro Val Lys Ser Asn
        195                 200                 205             
Phe Ser Ile Leu Gln Leu His Glu Phe Lys Phe Met Glu Gln Ser Arg
    210                 215                 220                 
Ser Pro Ser Val Ser Pro Ser Lys Gln Pro Val Ser Thr Ser Ser Lys
225                 230                 235                 240 
Thr Val Thr Leu Phe Glu Gln Tyr Cys Ser Gly Gly Asn Pro Phe Glu
                245                 250                 255     
Ile Gln Ala Asn His Lys Asp Glu Glu Thr Glu Asp Val Leu Ala Ser
            260                 265                 270         
Asn Gly Tyr Glu Ser Asp Glu Gln Glu Lys Ser Ala Tyr Gln Glu Tyr
        275                 280                 285             
Asp Ser Asp Ser Asp Val Pro Glu Glu Leu Lys Arg Asp Tyr Val Asp
    290                 295                 300                 
Glu Gln Thr Gly Asp Gly Pro Val Lys Ser Val Ser Arg Glu Thr Leu
305                 310                 315                 320 
Lys Ser Arg Lys Lys Ser Asp Tyr Ser Leu Asn Lys Val Asn Ala Pro
                325                 330                 335     
Ile Leu Thr Asn Thr Thr Leu Asn Val Ile Arg Leu Val Asp Gly Val
            340                 345                 350         
Ser Leu Cys Cys Leu Gly Trp Ser Thr Val Ala His Leu His Ser Leu
        355                 360                 365             
Gln Ala Pro Pro Pro Gly Phe Lys Pro Phe Ser Cys Leu Ser Leu Pro
    370                 375                 380                 
Arg Ser Trp Asp Tyr Arg Arg Pro Pro Pro Arg Pro Ala Asn Phe Leu
385                 390                 395                 400 
Tyr Phe Leu Leu Phe Ser Arg Asp Gly Val Ser Pro Cys
                405                 410             


<210> 7946
<211> 117
<212> PRT
<213> Homo sapiens

<400> 7946
Met Gly Arg Ala Ile Pro Lys Gly Arg Val Ser Lys Ser Leu Lys Val
 1               5                  10                  15      
Asn Pro Thr Leu Val Ile Gln Pro Thr Asn Leu Ser Ala Arg Leu Glu
            20                  25                  30          
Thr Asp Val Glu Cys Leu Lys Leu Asn Leu Phe Ser Thr Cys Ser Ala
        35                  40                  45              
Cys Asn Phe Trp Gly Ala Thr Val Ile Leu Val Lys Tyr Cys Glu Asp
    50                  55                  60                  
Ser Ser Glu Thr Glu Leu Ser Ser Pro Ser Met Tyr Ser Ala Ile Pro
65                  70                  75                  80  
Arg Leu Gln Val Cys Phe Phe His Arg Phe Gln Gly Gly Lys Asp Lys
                85                  90                  95      
Ala Ala Phe Leu Arg Pro Ser Asp Lys Asn Ser Pro Thr Asp Lys Tyr
            100                 105                 110         
Leu Val Ala Gln Thr
        115         


<210> 7947
<211> 5171
<212> PRT
<213> Homo sapiens

<400> 7947
Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser
 1               5                  10                  15      
Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu
            20                  25                  30          
Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly
        35                  40                  45              
Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala
    50                  55                  60                  
Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu
65                  70                  75                  80  
Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val
                85                  90                  95      
Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu
            100                 105                 110         
Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly
        115                 120                 125             
Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg
    130                 135                 140                 
Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys
145                 150                 155                 160 
Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile
                165                 170                 175     
Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu
            180                 185                 190         
Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser
        195                 200                 205             
Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser
    210                 215                 220                 
Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn
225                 230                 235                 240 
Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met
                245                 250                 255     
Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu
            260                 265                 270         
Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp
        275                 280                 285             
Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp
    290                 295                 300                 
Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg
305                 310                 315                 320 
Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu
                325                 330                 335     
Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His
            340                 345                 350         
Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln
        355                 360                 365             
Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn
    370                 375                 380                 
Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp
385                 390                 395                 400 
Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala
                405                 410                 415     
Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val
            420                 425                 430         
Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu
        435                 440                 445             
Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile
    450                 455                 460                 
Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala
465                 470                 475                 480 
Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg
                485                 490                 495     
Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser
            500                 505                 510         
Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys
        515                 520                 525             
Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys
    530                 535                 540                 
Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu
545                 550                 555                 560 
Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu
                565                 570                 575     
Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His
            580                 585                 590         
Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val
        595                 600                 605             
Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp
    610                 615                 620                 
Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp
625                 630                 635                 640 
His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu
                645                 650                 655     
Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys
            660                 665                 670         
Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser
        675                 680                 685             
Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser
    690                 695                 700                 
Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln
705                 710                 715                 720 
Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu
                725                 730                 735     
Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg
            740                 745                 750         
Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu
        755                 760                 765             
Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu
    770                 775                 780                 
Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile
785                 790                 795                 800 
Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser
                805                 810                 815     
Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn
            820                 825                 830         
Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val
        835                 840                 845             
Asn Leu Gly Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu
    850                 855                 860                 
Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn
865                 870                 875                 880 
Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val
                885                 890                 895     
Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys
            900                 905                 910         
Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp
        915                 920                 925             
Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg
    930                 935                 940                 
Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu
945                 950                 955                 960 
Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu
                965                 970                 975     
Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu
            980                 985                 990         
Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala Thr Gln Leu Asn Gln Gln
        995                 1000                1005            
Lys Met Leu Val Ser Glu Ile Glu Met Lys Gln Ser Lys Met Asp Glu
    1010                1015                1020                
Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala Thr Val Glu Asp Tyr Glu
1025                1030                1035                1040
Leu Gln Thr Met Thr Tyr Arg Ala Met Val Asp Ser Gln Gln Lys Ser
                1045                1050                1055    
Pro Val Lys Arg Arg Arg Met Gln Ser Ser Ala Asp Leu Ile Ile Gln
            1060                1065                1070        
Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu Val Thr Leu Met
        1075                1080                1085            
Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser Leu Lys Arg Leu Glu Glu
    1090                1095                1100                
Glu Glu Lys Ser Leu Glu Glu Glu Lys Lys Glu His Val Glu Lys Ala
1105                1110                1115                1120
Lys Glu Leu Gln Lys Trp Val Ser Asn Ile Ser Lys Thr Leu Lys Asp
                1125                1130                1135    
Ala Glu Lys Ala Gly Lys Pro Pro Phe Ser Lys Gln Lys Ile Ser Ser
            1140                1145                1150        
Glu Glu Ile Ser Thr Lys Lys Glu Gln Leu Ser Glu Ala Leu Gln Thr
        1155                1160                1165            
Ile Gln Leu Phe Leu Ala Lys His Gly Asp Lys Met Thr Asp Glu Glu
    1170                1175                1180                
Arg Asn Glu Leu Glu Lys Gln Val Lys Thr Leu Gln Glu Ser Tyr Asn
1185                1190                1195                1200
Leu Leu Phe Ser Glu Ser Leu Lys Gln Leu Gln Glu Ser Gln Thr Ser
                1205                1210                1215    
Gly Asp Val Lys Val Glu Glu Lys Ile Val Ala Glu Arg Gln Gln Glu
            1220                1225                1230        
Tyr Lys Glu Lys Leu Gln Gly Ile Cys Asp Leu Leu Thr Gln Thr Glu
        1235                1240                1245            
Asn Arg Leu Ile Gly His Gln Glu Ala Phe Met Ile Gly Asp Gly Thr
    1250                1255                1260                
Val Glu Leu Lys Lys Tyr Gln Ser Lys Gln Glu Glu Leu Gln Lys Asp
1265                1270                1275                1280
Met Gln Gly Ser Ala Gln Ala Leu Ala Glu Val Val Lys Asn Thr Glu
                1285                1290                1295    
Asn Phe Leu Lys Glu Asn Gly Glu Lys Leu Ser Gln Glu Asp Lys Ala
            1300                1305                1310        
Leu Ile Glu Gln Lys Leu Asn Glu Ala Lys Ile Lys Cys Glu Gln Leu
        1315                1320                1325            
Asn Leu Lys Ala Glu Gln Ser Lys Lys Glu Leu Asp Lys Val Val Thr
    1330                1335                1340                
Thr Ala Ile Lys Glu Glu Thr Glu Lys Val Ala Ala Val Lys Gln Leu
1345                1350                1355                1360
Glu Glu Ser Lys Thr Lys Ile Glu Asn Leu Leu Asp Trp Leu Ser Asn
                1365                1370                1375    
Val Asp Lys Asp Ser Glu Arg Ala Gly Thr Lys His Lys Gln Val Ile
            1380                1385                1390        
Glu Gln Asn Gly Thr His Phe Gln Glu Gly Asp Gly Lys Ser Ala Ile
        1395                1400                1405            
Gly Glu Glu Asp Glu Val Asn Gly Asn Leu Leu Glu Thr Asp Val Asp
    1410                1415                1420                
Gly Gln Val Gly Thr Thr Gln Glu Asn Leu Asn Gln Gln Tyr Gln Lys
1425                1430                1435                1440
Val Lys Ala Gln His Glu Lys Ile Ile Ser Gln His Gln Ala Val Ile
                1445                1450                1455    
Ile Ala Thr Gln Ser Ala Gln Val Leu Leu Glu Lys Gln Gly Gln Tyr
            1460                1465                1470        
Leu Ser Pro Glu Glu Lys Glu Lys Leu Gln Lys Asn Met Lys Glu Leu
        1475                1480                1485            
Lys Val His Tyr Glu Thr Ala Leu Ala Glu Ser Glu Lys Lys Met Lys
    1490                1495                1500                
Leu Thr His Ser Leu Gln Glu Glu Leu Glu Lys Phe Asp Ala Asp Tyr
1505                1510                1515                1520
Thr Glu Phe Glu His Trp Leu Gln Gln Ser Glu Gln Glu Leu Glu Asn
                1525                1530                1535    
Leu Glu Ala Gly Ala Asp Asp Ile Asn Gly Leu Met Thr Lys Leu Lys
            1540                1545                1550        
Arg Gln Lys Ser Phe Ser Glu Asp Val Ile Ser His Lys Gly Asp Leu
        1555                1560                1565            
Arg Tyr Ile Thr Ile Ser Gly Asn Arg Val Leu Glu Ala Ala Lys Ser
    1570                1575                1580                
Cys Ser Lys Arg Asp Gly Gly Lys Val Asp Thr Ser Ala Thr His Arg
1585                1590                1595                1600
Glu Val Gln Arg Lys Leu Asp His Ala Thr Asp Arg Phe Arg Ser Leu
                1605                1610                1615    
Tyr Ser Lys Cys Asn Val Leu Gly Asn Asn Leu Lys Asp Leu Val Asp
            1620                1625                1630        
Lys Tyr Gln His Tyr Glu Asp Ala Ser Cys Gly Leu Leu Ala Gly Leu
        1635                1640                1645            
Gln Ala Cys Glu Ala Thr Ala Ser Lys His Leu Ser Glu Pro Ile Ala
    1650                1655                1660                
Val Asp Pro Lys Asn Leu Gln Arg Gln Leu Glu Glu Thr Lys Ala Leu
1665                1670                1675                1680
Gln Gly Gln Ile Ser Ser Gln Gln Val Ala Val Glu Lys Leu Lys Lys
                1685                1690                1695    
Thr Ala Glu Val Leu Leu Asp Ala Arg Gly Ser Leu Leu Pro Ala Lys
            1700                1705                1710        
Asn Asp Ile Gln Lys Thr Leu Asp Asp Ile Val Gly Arg Tyr Glu Asp
        1715                1720                1725            
Leu Ser Lys Ser Val Asn Glu Arg Asn Glu Lys Leu Gln Ile Thr Leu
    1730                1735                1740                
Thr Arg Ser Leu Ser Val Gln Asp Gly Leu Asp Glu Met Leu Asp Trp
1745                1750                1755                1760
Met Gly Asn Val Glu Ser Ser Leu Lys Glu Gln Gly Gln Val Pro Leu
                1765                1770                1775    
Asn Ser Thr Ala Leu Gln Asp Ile Ile Ser Lys Asn Ile Met Leu Glu
            1780                1785                1790        
Gln Asp Ile Ala Gly Arg Gln Ser Ser Ile Asn Ala Met Asn Glu Lys
        1795                1800                1805            
Val Lys Lys Phe Met Glu Thr Thr Asp Pro Ser Thr Ala Ser Ser Leu
    1810                1815                1820                
Gln Ala Lys Met Lys Asp Leu Ser Ala Arg Phe Ser Glu Ala Ser His
1825                1830                1835                1840
Lys His Lys Glu Thr Leu Ala Lys Met Glu Glu Leu Lys Thr Lys Val
                1845                1850                1855    
Glu Leu Phe Glu Asn Leu Ser Glu Lys Leu Gln Thr Phe Leu Glu Thr
            1860                1865                1870        
Lys Thr Gln Ala Leu Thr Glu Val Asp Val Pro Gly Lys Asp Val Thr
        1875                1880                1885            
Glu Leu Ser Gln Tyr Met Gln Glu Ser Thr Ser Glu Phe Leu Glu His
    1890                1895                1900                
Lys Lys His Leu Glu Val Leu His Ser Leu Leu Lys Glu Ile Ser Ser
1905                1910                1915                1920
His Gly Leu Pro Ser Asp Lys Ala Leu Val Leu Glu Lys Thr Asn Asn
                1925                1930                1935    
Leu Ser Lys Lys Phe Lys Glu Met Glu Asp Thr Ile Lys Glu Lys Lys
            1940                1945                1950        
Glu Ala Val Thr Ser Cys Gln Glu Gln Leu Asp Ala Phe Gln Val Leu
        1955                1960                1965            
Val Lys Ser Leu Lys Ser Trp Ile Lys Glu Thr Thr Lys Lys Val Pro
    1970                1975                1980                
Ile Val Gln Pro Ser Phe Gly Ala Glu Asp Leu Gly Lys Ser Leu Glu
1985                1990                1995                2000
Asp Thr Lys Lys Leu Gln Glu Lys Trp Ser Leu Lys Thr Pro Glu Ile
                2005                2010                2015    
Gln Lys Val Asn Asn Ser Gly Ile Ser Leu Cys Asn Leu Ile Ser Ala
            2020                2025                2030        
Val Thr Thr Pro Ala Lys Ala Ile Ala Ala Val Lys Ser Gly Gly Ala
        2035                2040                2045            
Val Leu Asn Gly Glu Gly Thr Ala Thr Asn Thr Glu Glu Phe Trp Ala
    2050                2055                2060                
Asn Lys Gly Leu Thr Ser Ile Lys Lys Asp Met Thr Asp Ile Ser His
2065                2070                2075                2080
Gly Tyr Glu Asp Leu Gly Leu Leu Leu Lys Asp Lys Ile Ala Glu Leu
                2085                2090                2095    
Asn Thr Lys Leu Ser Lys Leu Gln Lys Ala Gln Glu Glu Ser Ser Ala
            2100                2105                2110        
Met Met Gln Trp Leu Gln Lys Met Asn Lys Thr Ala Thr Lys Trp Gln
        2115                2120                2125            
Gln Thr Pro Ala Pro Thr Asp Thr Glu Ala Val Lys Thr Gln Val Glu
    2130                2135                2140                
Gln Asn Lys Ser Phe Glu Ala Glu Leu Lys Gln Asn Val Asn Lys Val
2145                2150                2155                2160
Gln Glu Leu Lys Asp Lys Leu Thr Glu Leu Leu Glu Glu Asn Pro Asp
                2165                2170                2175    
Thr Pro Glu Ala Pro Arg Trp Lys Gln Met Leu Thr Glu Ile Asp Ser
            2180                2185                2190        
Lys Trp Gln Glu Leu Asn Gln Leu Thr Ile Asp Arg Gln Gln Lys Leu
        2195                2200                2205            
Glu Glu Ser Ser Asn Asn Leu Thr Gln Phe Gln Thr Val Glu Ala Gln
    2210                2215                2220                
Leu Lys Gln Trp Leu Val Glu Lys Glu Leu Met Val Ser Val Leu Gly
2225                2230                2235                2240
Pro Leu Ser Ile Asp Pro Asn Met Leu Asn Thr Gln Arg Gln Gln Val
                2245                2250                2255    
Gln Ile Leu Leu Gln Glu Phe Ala Thr Arg Lys Pro Gln Tyr Glu Gln
            2260                2265                2270        
Leu Thr Ala Ala Gly Gln Gly Ile Leu Ser Arg Pro Gly Glu Asp Pro
        2275                2280                2285            
Ser Leu Arg Gly Ile Val Lys Glu Gln Leu Ala Ala Val Thr Gln Lys
    2290                2295                2300                
Trp Asp Ser Leu Thr Gly Gln Leu Ser Asp Arg Cys Asp Trp Ile Asp
2305                2310                2315                2320
Gln Ala Ile Val Lys Ser Thr Gln Tyr Gln Ser Leu Leu Arg Ser Leu
                2325                2330                2335    
Ser Asp Lys Leu Ser Asp Leu Asp Asn Lys Leu Ser Ser Ser Leu Ala
            2340                2345                2350        
Val Ser Thr His Pro Asp Ala Met Asn Gln Gln Leu Glu Thr Ala Gln
        2355                2360                2365            
Lys Met Lys Gln Glu Ile Gln Gln Glu Lys Lys Gln Ile Lys Val Ala
    2370                2375                2380                
Gln Ala Leu Cys Glu Asp Leu Ser Ala Leu Val Lys Glu Glu Tyr Leu
2385                2390                2395                2400
Lys Ala Glu Leu Ser Arg Gln Leu Glu Gly Ile Leu Lys Ser Phe Lys
                2405                2410                2415    
Asp Val Glu Gln Lys Ala Glu Asn His Val Gln His Leu Gln Ser Ala
            2420                2425                2430        
Cys Ala Ser Ser His Gln Phe Gln Gln Met Ser Arg Asp Phe Gln Ala
        2435                2440                2445            
Trp Leu Asp Thr Lys Lys Glu Glu Gln Asn Lys Ser His Pro Ile Ser
    2450                2455                2460                
Ala Lys Leu Asp Val Leu Glu Ser Leu Ile Lys Asp His Lys Asp Phe
2465                2470                2475                2480
Ser Lys Thr Leu Thr Ala Gln Ser His Met Tyr Glu Lys Thr Ile Ala
                2485                2490                2495    
Glu Gly Glu Asn Leu Leu Leu Lys Thr Gln Gly Ser Glu Lys Ala Ala
            2500                2505                2510        
Leu Gln Leu Gln Leu Asn Thr Ile Lys Thr Asn Trp Asp Thr Phe Asn
        2515                2520                2525            
Lys Gln Val Lys Glu Arg Glu Asn Lys Leu Lys Glu Ser Leu Glu Lys
    2530                2535                2540                
Ala Leu Lys Tyr Lys Glu Gln Val Glu Thr Leu Trp Pro Trp Ile Asp
2545                2550                2555                2560
Lys Cys Gln Asn Asn Leu Glu Glu Ile Lys Phe Cys Leu Asp Pro Ala
                2565                2570                2575    
Glu Gly Glu Asn Ser Ile Ala Lys Leu Lys Ser Leu Gln Lys Glu Met
            2580                2585                2590        
Asp Gln His Phe Gly Met Val Glu Leu Leu Asn Asn Thr Ala Asn Ser
        2595                2600                2605            
Leu Leu Ser Val Cys Glu Ile Asp Lys Gly Val Val Thr Asp Glu Asn
    2610                2615                2620                
Lys Ser Leu Ile Gln Lys Val Asp Met Val Thr Glu Gln Leu His Ser
2625                2630                2635                2640
Lys Lys Phe Cys Leu Glu Asn Met Thr Gln Lys Phe Lys Glu Phe Gln
                2645                2650                2655    
Glu Val Ser Lys Glu Ser Lys Arg Gln Leu Gln Cys Ala Lys Glu Gln
            2660                2665                2670        
Leu Asp Ile His Asp Ser Leu Gly Ser Gln Ala Tyr Ser Asn Lys Tyr
        2675                2680                2685            
Leu Thr Met Leu Gln Thr Gln Gln Lys Ser Leu Gln Ala Leu Lys His
    2690                2695                2700                
Gln Val Asp Leu Ala Lys Arg Leu Ala Gln Asp Leu Val Val Glu Ala
2705                2710                2715                2720
Ser Asp Ser Lys Gly Thr Ser Asp Val Leu Leu Gln Val Glu Thr Ile
                2725                2730                2735    
Ala Gln Glu His Ser Thr Leu Ser Gln Gln Val Asp Glu Lys Cys Ser
            2740                2745                2750        
Phe Leu Glu Thr Lys Leu Gln Gly Ile Gly His Phe Arg Asn Thr Ile
        2755                2760                2765            
Arg Glu Met Phe Ser Gln Phe Ala Glu Phe Asp Asp Glu Leu Asp Ser
    2770                2775                2780                
Met Ala Pro Val Gly Arg Asp Ala Glu Thr Leu Gln Lys Gln Lys Glu
2785                2790                2795                2800
Thr Ile Lys Ala Phe Leu Lys Lys Leu Glu Ala Leu Met Ala Ser Asn
                2805                2810                2815    
Asp Asn Ala Asn Lys Thr Cys Lys Met Met Leu Ala Thr Glu Glu Thr
            2820                2825                2830        
Ser Pro Asp Leu Val Gly Ile Lys Arg Asp Leu Glu Ala Leu Ser Lys
        2835                2840                2845            
Gln Cys Asn Lys Leu Leu Asp Arg Ala Gln Ala Arg Glu Glu Gln Val
    2850                2855                2860                
Glu Gly Thr Ile Lys Arg Leu Glu Glu Phe Tyr Ser Lys Leu Lys Glu
2865                2870                2875                2880
Phe Ser Ile Leu Leu Gln Arg Ala Glu Glu His Glu Glu Ser Gln Gly
                2885                2890                2895    
Pro Val Gly Met Glu Thr Glu Thr Ile Asn Gln Gln Leu Asn Met Phe
            2900                2905                2910        
Lys Val Phe Gln Lys Glu Glu Ile Glu Pro Leu Gln Gly Lys Gln Gln
        2915                2920                2925            
Asp Val Asn Trp Leu Gly Gln Gly Leu Ile Gln Ser Ala Ala Lys Ser
    2930                2935                2940                
Thr Ser Thr Gln Gly Leu Glu His Asp Leu Asp Asp Val Asn Ala Arg
2945                2950                2955                2960
Trp Lys Thr Leu Asn Lys Lys Val Ala Gln Arg Ala Ala Gln Leu Gln
                2965                2970                2975    
Glu Ala Leu Leu His Cys Gly Arg Phe Gln Asp Ala Leu Glu Ser Leu
            2980                2985                2990        
Leu Ser Trp Met Val Asp Thr Glu Glu Leu Val Ala Asn Gln Lys Pro
        2995                3000                3005            
Pro Ser Ala Glu Phe Lys Val Val Lys Ala Gln Ile Gln Glu Gln Lys
    3010                3015                3020                
Leu Leu Gln Arg Leu Leu Asp Asp Arg Lys Ser Thr Val Glu Val Ile
3025                3030                3035                3040
Lys Arg Glu Gly Glu Lys Ile Ala Thr Thr Ala Glu Pro Ala Asp Lys
                3045                3050                3055    
Val Lys Ile Leu Lys Gln Leu Ser Leu Leu Asp Ser Arg Trp Glu Ala
            3060                3065                3070        
Leu Leu Asn Lys Ala Glu Thr Arg Asn Arg Gln Leu Glu Gly Ile Ser
        3075                3080                3085            
Val Val Ala Gln Gln Phe His Glu Thr Leu Glu Pro Leu Asn Glu Trp
    3090                3095                3100                
Leu Thr Thr Ile Glu Lys Arg Leu Val Asn Cys Glu Pro Ile Gly Thr
3105                3110                3115                3120
Gln Ala Ser Lys Leu Glu Glu Gln Ile Ala Gln His Lys Ala Leu Glu
                3125                3130                3135    
Asp Asp Ile Ile Asn His Asn Lys His Leu His Gln Ala Val Ser Ile
            3140                3145                3150        
Gly Gln Ser Leu Lys Val Leu Ser Ser Arg Glu Asp Lys Asp Met Val
        3155                3160                3165            
Gln Ser Lys Leu Asp Phe Ser Gln Val Trp Tyr Ile Glu Ile Gln Glu
    3170                3175                3180                
Lys Ser His Ser Arg Ser Glu Leu Leu Gln Gln Ala Leu Cys Asn Ala
3185                3190                3195                3200
Lys Ile Phe Gly Glu Asp Glu Val Glu Leu Met Asn Trp Leu Asn Glu
                3205                3210                3215    
Val His Asp Lys Leu Ser Lys Leu Ser Val Gln Asp Tyr Ser Thr Glu
            3220                3225                3230        
Gly Leu Trp Lys Gln Gln Ser Glu Leu Arg Val Leu Gln Glu Asp Ile
        3235                3240                3245            
Leu Leu Arg Lys Gln Asn Val Asp Gln Ala Leu Leu Asn Gly Leu Glu
    3250                3255                3260                
Leu Leu Lys Gln Thr Thr Gly Asp Glu Val Leu Ile Ile Gln Asp Lys
3265                3270                3275                3280
Leu Glu Ala Ile Lys Ala Arg Tyr Lys Asp Ile Thr Lys Leu Ser Thr
                3285                3290                3295    
Asp Val Ala Lys Thr Leu Glu Gln Ala Leu Gln Leu Ala Arg Arg Leu
            3300                3305                3310        
His Ser Thr His Glu Glu Leu Cys Thr Trp Leu Asp Lys Val Glu Val
        3315                3320                3325            
Glu Leu Leu Ser Tyr Glu Thr Gln Val Leu Lys Gly Glu Glu Ala Ser
    3330                3335                3340                
Gln Ala Gln Met Arg Pro Lys Glu Leu Lys Lys Glu Ala Lys Asn Asn
3345                3350                3355                3360
Lys Ala Leu Leu Asp Ser Leu Asn Glu Val Ser Ser Ala Leu Leu Glu
                3365                3370                3375    
Leu Val Pro Trp Arg Ala Arg Glu Gly Leu Glu Lys Met Val Ala Glu
            3380                3385                3390        
Asp Asn Glu Arg Tyr Arg Leu Val Ser Asp Thr Ile Thr Gln Lys Val
        3395                3400                3405            
Glu Glu Val Asp Ala Ala Ile Leu Arg Ser Gln Gln Phe Asp Gln Ala
    3410                3415                3420                
Ala Asp Ala Glu Leu Ser Trp Ile Thr Glu Thr Glu Lys Lys Leu Met
3425                3430                3435                3440
Ser Leu Gly Asp Ile Arg Leu Glu Gln Asp Gln Thr Ser Ala Gln Leu
                3445                3450                3455    
Gln Val Gln Lys Thr Phe Thr Met Glu Ile Leu Arg His Arg Asp Ile
            3460                3465                3470        
Ile Asp Asp Leu Val Lys Ser Gly His Lys Ile Met Thr Ala Cys Ser
        3475                3480                3485            
Glu Glu Glu Lys Gln Ser Met Lys Lys Lys Leu Asp Lys Val Leu Lys
    3490                3495                3500                
Asn Tyr Asp Thr Ile Cys Gln Ile Asn Ser Glu Arg Tyr Leu Gln Leu
3505                3510                3515                3520
Glu Arg Ala Gln Ser Leu Val Asn Gln Phe Trp Glu Thr Tyr Glu Glu
                3525                3530                3535    
Leu Trp Pro Trp Leu Thr Glu Thr Gln Ser Ile Ile Ser Gln Leu Pro
            3540                3545                3550        
Ala Pro Ala Leu Glu Tyr Glu Thr Leu Arg Gln Gln Gln Glu Glu His
        3555                3560                3565            
Arg Gln Leu Arg Glu Ser Ile Ala Glu His Lys Pro His Ile Asp Lys
    3570                3575                3580                
Met Asn Lys Thr Gly Pro Gln Leu Leu Glu Leu Ser Pro Gly Glu Gly
3585                3590                3595                3600
Phe Ser Ile Gln Glu Lys Tyr Val Ala Ala Asp Thr Leu Tyr Ser Gln
                3605                3610                3615    
Ile Lys Glu Asp Val Lys Lys Arg Ala Val Ala Leu Asp Glu Ala Ile
            3620                3625                3630        
Ser Gln Ser Thr Gln Phe His Asp Lys Ile Asp Gln Ile Leu Glu Ser
        3635                3640                3645            
Leu Glu Arg Ile Val Glu Arg Leu Arg Gln Pro Pro Ser Ile Ser Ala
    3650                3655                3660                
Glu Val Glu Lys Ile Lys Glu Gln Ile Ser Glu Asn Lys Asn Val Ser
3665                3670                3675                3680
Val Asp Met Glu Lys Leu Gln Pro Leu Tyr Glu Thr Leu Lys Gln Arg
                3685                3690                3695    
Gly Glu Glu Met Ile Ala Arg Ser Gly Gly Thr Asp Lys Asp Ile Ser
            3700                3705                3710        
Ala Lys Ala Val Gln Asp Lys Leu Asp Gln Met Val Phe Ile Trp Glu
        3715                3720                3725            
Asn Ile His Thr Leu Val Glu Glu Arg Glu Ala Lys Leu Leu Asp Val
    3730                3735                3740                
Met Glu Leu Ala Glu Lys Phe Trp Cys Asp His Met Ser Leu Ile Val
3745                3750                3755                3760
Thr Ile Lys Asp Thr Gln Asp Phe Ile Arg Asp Leu Glu Gly Pro Gly
                3765                3770                3775    
Ile Asp Pro Ser Val Val Lys Gln Gln Gln Glu Ala Ala Glu Thr Ile
            3780                3785                3790        
Arg Glu Glu Ile Asp Gly Leu Gln Glu Glu Leu Asp Ile Val Ile Asn
        3795                3800                3805            
Leu Gly Ser Glu Leu Ile Ala Ala Cys Gly Glu Pro Asp Lys Pro Ile
    3810                3815                3820                
Val Lys Lys Ser Ile Asp Glu Leu Asn Ser Ala Trp Asp Ser Leu Asn
3825                3830                3835                3840
Lys Ala Trp Lys Asp Arg Ile Asp Lys Leu Glu Glu Ala Met Gln Ala
                3845                3850                3855    
Ala Val Gln Tyr Gln Asp Gly Leu Gln Ala Val Phe Asp Trp Val Asp
            3860                3865                3870        
Ile Ala Gly Gly Lys Leu Ala Ser Met Ser Pro Ile Gly Thr Asp Leu
        3875                3880                3885            
Glu Thr Val Lys Gln Gln Ile Glu Glu Leu Lys Gln Phe Lys Ser Glu
    3890                3895                3900                
Ala Tyr Gln Gln Gln Ile Glu Met Glu Arg Leu Asn His Gln Ala Glu
3905                3910                3915                3920
Leu Leu Leu Lys Lys Val Thr Glu Glu Ser Asp Lys His Thr Val Gln
                3925                3930                3935    
Asp Pro Leu Met Glu Leu Lys Leu Ile Trp Asp Ser Leu Glu Glu Arg
            3940                3945                3950        
Ile Ile Asn Arg Gln His Lys Leu Glu Gly Ala Leu Leu Ala Leu Gly
        3955                3960                3965            
Gln Phe Gln His Ala Leu Asp Glu Leu Leu Ala Trp Leu Thr His Thr
    3970                3975                3980                
Glu Gly Leu Leu Ser Glu Gln Lys Pro Val Gly Gly Asp Pro Lys Ala
3985                3990                3995                4000
Ile Glu Ile Glu Leu Ala Lys His His Val Leu Gln Asn Asp Val Leu
                4005                4010                4015    
Ala His Gln Ser Thr Val Glu Ala Val Asn Lys Gly Gly Asn Asp Leu
            4020                4025                4030        
Ile Glu Ser Ser Ala Gly Glu Glu Ala Ser Asn Leu Gln Asn Lys Leu
        4035                4040                4045            
Glu Val Leu Asn Gln Arg Trp Gln Asn Val Leu Glu Lys Thr Glu Gln
    4050                4055                4060                
Arg Lys Gln Gln Leu Asp Gly Ala Leu Arg Gln Ala Lys Gly Phe His
4065                4070                4075                4080
Gly Glu Ile Glu Asp Leu Gln Gln Trp Leu Thr Asp Thr Glu Arg His
                4085                4090                4095    
Leu Leu Ala Ser Lys Pro Leu Gly Gly Leu Pro Glu Thr Ala Lys Glu
            4100                4105                4110        
Gln Leu Asn Val His Met Glu Val Cys Ala Ala Phe Glu Ala Lys Glu
        4115                4120                4125            
Glu Thr Tyr Lys Ser Leu Met Gln Lys Gly Gln Gln Met Leu Ala Arg
    4130                4135                4140                
Cys Pro Lys Ser Ala Glu Thr Asn Ile Asp Gln Asp Ile Asn Asn Leu
4145                4150                4155                4160
Lys Glu Lys Trp Glu Ser Val Glu Thr Lys Leu Asn Glu Arg Lys Thr
                4165                4170                4175    
Lys Leu Glu Glu Ala Leu Asn Leu Ala Met Glu Phe His Asn Ser Leu
            4180                4185                4190        
Gln Asp Phe Ile Asn Trp Leu Thr Gln Ala Glu Gln Thr Leu Asn Val
        4195                4200                4205            
Ala Ser Arg Pro Ser Leu Ile Leu Asp Thr Val Leu Phe Gln Ile Asp
    4210                4215                4220                
Glu His Lys Val Phe Ala Asn Glu Val Asn Ser His Arg Glu Gln Ile
4225                4230                4235                4240
Ile Glu Leu Asp Lys Thr Gly Thr His Leu Lys Tyr Phe Ser Gln Lys
                4245                4250                4255    
Gln Asp Val Val Leu Ile Lys Asn Leu Leu Ile Ser Val Gln Ser Arg
            4260                4265                4270        
Trp Glu Lys Val Val Gln Arg Leu Val Glu Arg Gly Arg Ser Leu Asp
        4275                4280                4285            
Asp Ala Arg Lys Arg Ala Lys Gln Phe His Glu Ala Trp Ser Lys Leu
    4290                4295                4300                
Met Glu Trp Leu Glu Glu Ser Glu Lys Ser Leu Asp Ser Glu Leu Glu
4305                4310                4315                4320
Ile Ala Asn Asp Pro Asp Lys Ile Lys Thr Gln Leu Ala Gln His Lys
                4325                4330                4335    
Glu Phe Gln Lys Ser Leu Gly Ala Lys His Ser Val Tyr Asp Thr Thr
            4340                4345                4350        
Asn Arg Thr Gly Arg Ser Leu Lys Glu Lys Thr Ser Leu Ala Asp Asp
        4355                4360                4365            
Asn Leu Lys Leu Asp Asp Met Leu Ser Glu Leu Arg Asp Lys Trp Asp
    4370                4375                4380                
Thr Ile Cys Gly Lys Ser Val Glu Arg Gln Asn Lys Leu Glu Glu Ala
4385                4390                4395                4400
Leu Leu Phe Ser Gly Gln Phe Thr Asp Ala Leu Gln Ala Leu Ile Asp
                4405                4410                4415    
Trp Leu Tyr Arg Val Glu Pro Gln Leu Ala Glu Asp Gln Pro Val His
            4420                4425                4430        
Gly Asp Ile Asp Leu Val Met Asn Leu Ile Asp Asn His Lys Ala Phe
        4435                4440                4445            
Gln Lys Glu Leu Gly Lys Arg Thr Ser Ser Val Gln Ala Leu Lys Arg
    4450                4455                4460                
Ser Ala Arg Glu Leu Ile Glu Gly Ser Arg Asp Asp Ser Ser Trp Val
4465                4470                4475                4480
Lys Val Gln Met Gln Glu Leu Ser Thr Arg Trp Glu Thr Val Cys Ala
                4485                4490                4495    
Leu Ser Ile Ser Lys Gln Thr Arg Leu Glu Ala Ala Leu Arg Gln Ala
            4500                4505                4510        
Glu Glu Phe His Ser Val Val His Ala Leu Leu Glu Trp Leu Ala Glu
        4515                4520                4525            
Ala Glu Gln Thr Leu Arg Phe His Gly Val Leu Pro Asp Asp Glu Asp
    4530                4535                4540                
Ala Leu Arg Thr Leu Ile Asp Gln His Lys Glu Phe Met Lys Lys Leu
4545                4550                4555                4560
Glu Glu Lys Arg Ala Glu Leu Asn Lys Ala Thr Thr Met Gly Asp Thr
                4565                4570                4575    
Val Leu Ala Ile Cys His Pro Asp Ser Ile Thr Thr Ile Lys His Trp
            4580                4585                4590        
Ile Thr Ile Ile Arg Ala Arg Phe Glu Glu Val Leu Ala Trp Ala Lys
        4595                4600                4605            
Gln His Gln Gln Arg Leu Ala Ser Ala Leu Ala Gly Leu Ile Ala Lys
    4610                4615                4620                
Gln Glu Leu Leu Glu Ala Leu Leu Ala Trp Leu Gln Trp Ala Glu Thr
4625                4630                4635                4640
Thr Leu Thr Asp Lys Asp Lys Glu Val Ile Pro Gln Glu Ile Glu Glu
                4645                4650                4655    
Val Lys Ala Leu Ile Ala Glu His Gln Thr Phe Met Glu Glu Met Thr
            4660                4665                4670        
Arg Lys Gln Pro Asp Val Asp Lys Val Thr Lys Thr Tyr Lys Arg Arg
        4675                4680                4685            
Ala Ala Asp Pro Ser Ser Leu Gln Ser His Ile Pro Val Leu Asp Lys
    4690                4695                4700                
Gly Arg Ala Gly Arg Lys Arg Phe Pro Ala Ser Ser Leu Tyr Pro Ser
4705                4710                4715                4720
Gly Ser Gln Thr Gln Ile Glu Thr Lys Asn Pro Arg Val Asn Leu Leu
                4725                4730                4735    
Val Ser Lys Trp Gln Gln Val Trp Leu Leu Ala Leu Glu Arg Arg Arg
            4740                4745                4750        
Lys Leu Asn Asp Ala Leu Asp Arg Leu Glu Glu Leu Arg Glu Phe Ala
        4755                4760                4765            
Asn Phe Asp Phe Asp Ile Trp Arg Lys Lys Tyr Met Arg Trp Met Asn
    4770                4775                4780                
His Lys Lys Ser Arg Val Met Asp Phe Phe Arg Arg Ile Asp Lys Asp
4785                4790                4795                4800
Gln Asp Gly Lys Ile Thr Arg Gln Glu Phe Ile Asp Gly Ile Leu Ser
                4805                4810                4815    
Ser Lys Phe Pro Thr Ser Arg Leu Glu Met Ser Ala Val Ala Asp Ile
            4820                4825                4830        
Phe Asp Arg Asp Gly Asp Gly Tyr Ile Asp Tyr Tyr Glu Phe Val Ala
        4835                4840                4845            
Ala Leu His Pro Asn Lys Asp Ala Tyr Lys Pro Ile Thr Asp Ala Asp
    4850                4855                4860                
Lys Ile Glu Asp Glu Val Thr Arg Gln Val Ala Lys Cys Lys Cys Ala
4865                4870                4875                4880
Lys Arg Phe Gln Val Glu Gln Ile Gly Asp Asn Lys Tyr Arg Phe Phe
                4885                4890                4895    
Leu Gly Asn Gln Phe Gly Asp Ser Gln Gln Leu Arg Leu Val Arg Ile
            4900                4905                4910        
Leu Arg Ser Thr Val Met Val Arg Val Gly Gly Gly Trp Met Ala Leu
        4915                4920                4925            
Asp Glu Phe Leu Val Lys Asn Asp Pro Cys Arg Ala Lys Gly Arg Thr
    4930                4935                4940                
Asn Met Glu Leu Arg Glu Lys Phe Ile Leu Ala Asp Gly Ala Ser Gln
4945                4950                4955                4960
Gly Met Ala Ala Phe Arg Pro Arg Gly Arg Arg Ser Arg Pro Ser Ser
                4965                4970                4975    
Arg Gly Ala Ser Pro Asn Arg Ser Thr Ser Val Ser Ser Gln Ala Ala
            4980                4985                4990        
Gln Ala Ala Ser Pro Gln Val Pro Ala Thr Thr Thr Pro Lys Ile Leu
        4995                5000                5005            
His Pro Leu Thr Arg Asn Tyr Gly Lys Pro Trp Leu Thr Asn Ser Lys
    5010                5015                5020                
Met Ser Thr Pro Cys Lys Ala Ala Glu Cys Ser Asp Phe Pro Val Pro
5025                5030                5035                5040
Ser Ala Glu Gly Thr Pro Ile Gln Gly Ser Lys Leu Arg Leu Pro Gly
                5045                5050                5055    
Tyr Leu Ser Gly Lys Gly Phe His Ser Gly Glu Asp Ser Gly Leu Ile
            5060                5065                5070        
Thr Thr Ala Ala Ala Arg Val Arg Thr Gln Phe Ala Asp Ser Lys Lys
        5075                5080                5085            
Thr Pro Ser Arg Pro Gly Ser Arg Ala Gly Ser Lys Ala Gly Ser Arg
    5090                5095                5100                
Ala Ser Ser Arg Arg Gly Ser Asp Ala Ser Asp Phe Asp Ile Ser Glu
5105                5110                5115                5120
Ile Gln Ser Val Cys Ser Asp Val Glu Thr Val Pro Gln Thr His Arg
                5125                5130                5135    
Pro Thr Pro Arg Ala Gly Ser Arg Pro Ser Thr Ala Lys Pro Ser Lys
            5140                5145                5150        
Ile Pro Thr Pro Gln Arg Lys Ser Pro Ala Ser Lys Leu Asp Lys Ser
        5155                5160                5165            
Ser Lys Arg
    5170    


<210> 7948
<211> 5497
<212> PRT
<213> Homo sapiens

<400> 7948
Met Ala Gly Tyr Leu Ser Pro Ala Ala Tyr Leu Tyr Val Glu Glu Gln
 1               5                  10                  15      
Glu Tyr Leu Gln Ala Tyr Glu Asp Val Leu Glu Arg Tyr Lys Asp Glu
            20                  25                  30          
Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln His
        35                  40                  45              
Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu Arg
    50                  55                  60                  
Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Thr
65                  70                  75                  80  
Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val
                85                  90                  95      
Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn
            100                 105                 110         
Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly
        115                 120                 125             
Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val
    130                 135                 140                 
Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp
145                 150                 155                 160 
Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe
                165                 170                 175     
Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys
            180                 185                 190         
Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn
        195                 200                 205             
Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val
    210                 215                 220                 
Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu
225                 230                 235                 240 
Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys
                245                 250                 255     
Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys
            260                 265                 270         
Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg
        275                 280                 285             
His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val
    290                 295                 300                 
Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu
305                 310                 315                 320 
Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys
                325                 330                 335     
Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu Gln Gly
            340                 345                 350         
Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile Ile Ala
        355                 360                 365             
Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg Leu Glu
    370                 375                 380                 
Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val Ile Cys
385                 390                 395                 400 
Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys
                405                 410                 415     
Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly
            420                 425                 430         
Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile Asp Val
        435                 440                 445             
Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln
    450                 455                 460                 
Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn Glu Cys
465                 470                 475                 480 
Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys
                485                 490                 495     
Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln
            500                 505                 510         
Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro
        515                 520                 525             
Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly Met Thr
    530                 535                 540                 
Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro
545                 550                 555                 560 
Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn Ser Leu
                565                 570                 575     
Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser
            580                 585                 590         
Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys Phe Val
        595                 600                 605             
Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu Asp Arg
    610                 615                 620                 
Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu Glu Asn
625                 630                 635                 640 
His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys
                645                 650                 655     
Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys Leu Thr
            660                 665                 670         
Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu
        675                 680                 685             
Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe
    690                 695                 700                 
Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu
705                 710                 715                 720 
Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg
                725                 730                 735     
Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu
            740                 745                 750         
Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu
        755                 760                 765             
Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln
    770                 775                 780                 
Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu Gln His
785                 790                 795                 800 
Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu
                805                 810                 815     
Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr
            820                 825                 830         
Ser Cys Asp Arg Ser Ser Ser Ile His Lys Leu Glu Asp Leu Val Gln
        835                 840                 845             
Glu Ser Met Glu Glu Lys Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile
    850                 855                 860                 
Ala Asn Leu Met Gly Lys Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg
865                 870                 875                 880 
Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys
                885                 890                 895     
Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val
            900                 905                 910         
Leu Ala Asn Asn Ser His Arg Ala Lys Trp Lys Val Ile Ser Pro Thr
        915                 920                 925             
Gly Asn Glu Ala Met Val Pro Ser Val Cys Phe Thr Val Pro Pro Pro
    930                 935                 940                 
Asn Lys Glu Ala Val Asp Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln
945                 950                 955                 960 
Asn Val Leu Thr Leu Trp His Glu Ser His Ile Asn Met Lys Ser Val
                965                 970                 975     
Val Ser Trp His Tyr Leu Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser
            980                 985                 990         
Asn Val Ala Ser Ile Lys Thr Met Leu Pro Gly Glu His Gln Gln Val
        995                 1000                1005            
Leu Ser Asn Leu Gln Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln
    1010                1015                1020                
Glu Ser Gln Val Phe Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu
1025                1030                1035                1040
Val Asn Val Cys Lys Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu
                1045                1050                1055    
Arg Glu Glu Gln Glu Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val
            1060                1065                1070        
Arg Asn Ile Arg Leu Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg
        1075                1080                1085            
Gln Ile Arg Thr Pro Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe
    1090                1095                1100                
Arg Ile Thr Glu Gln Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys
1105                1110                1115                1120
Asp Asp Leu Gly Thr Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln
                1125                1130                1135    
Ala Ala Ala Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val
            1140                1145                1150        
Val Leu Gln Asn Met Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile
        1155                1160                1165            
Asp Lys Leu Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala Ala
    1170                1175                1180                
Glu Ala Leu Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala
1185                1190                1195                1200
Val Ile Ala Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys
                1205                1210                1215    
Gln Trp Arg Ser Glu Val Asp Glu Lys Arg Gln Val Phe His Ala Leu
            1220                1225                1230        
Glu Asp Glu Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe Lys
        1235                1240                1245            
Thr Tyr Lys Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys Ala
    1250                1255                1260                
Asp Gln Leu Val Glu Arg Trp Gln Asn Val His Val Gln Ile Asp Asn
1265                1270                1275                1280
Arg Leu Arg Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg
                1285                1290                1295    
Asp Thr Tyr His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr Thr
            1300                1305                1310        
Gln Arg Lys Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala
        1315                1320                1325            
Thr Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met Lys
    1330                1335                1340                
Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala
1345                1350                1355                1360
Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met Val
                1365                1370                1375    
Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser Ser
            1380                1385                1390        
Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr
        1395                1400                1405            
Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser
    1410                1415                1420                
Leu Lys Arg Leu Glu Glu Glu Glu Lys Ser Leu Glu Glu Glu Lys Lys
1425                1430                1435                1440
Glu His Val Glu Lys Ala Lys Glu Leu Gln Lys Trp Val Ser Asn Ile
                1445                1450                1455    
Ser Lys Thr Leu Lys Asp Ala Glu Lys Ala Gly Lys Pro Pro Phe Ser
            1460                1465                1470        
Lys Gln Lys Ile Ser Ser Glu Glu Ile Ser Thr Lys Lys Glu Gln Leu
        1475                1480                1485            
Ser Glu Ala Leu Gln Thr Ile Gln Leu Phe Leu Ala Lys His Gly Asp
    1490                1495                1500                
Lys Met Thr Asp Glu Glu Arg Asn Glu Leu Glu Lys Gln Val Lys Thr
1505                1510                1515                1520
Leu Gln Glu Ser Tyr Asn Leu Leu Phe Ser Glu Ser Leu Lys Gln Leu
                1525                1530                1535    
Gln Glu Ser Gln Thr Ser Gly Asp Val Lys Val Glu Glu Lys Ile Val
            1540                1545                1550        
Ala Glu Arg Gln Gln Glu Tyr Lys Glu Lys Leu Gln Gly Ile Cys Asp
        1555                1560                1565            
Leu Leu Thr Gln Thr Glu Asn Arg Leu Ile Gly His Gln Glu Ala Phe
    1570                1575                1580                
Met Ile Gly Asp Gly Thr Val Glu Leu Lys Lys Tyr Gln Ser Lys Gln
1585                1590                1595                1600
Glu Glu Leu Gln Lys Asp Met Gln Gly Ser Ala Gln Ala Leu Ala Glu
                1605                1610                1615    
Val Val Lys Asn Thr Glu Asn Phe Leu Lys Glu Asn Gly Glu Lys Leu
            1620                1625                1630        
Ser Gln Glu Asp Lys Ala Leu Ile Glu Gln Lys Leu Asn Glu Ala Lys
        1635                1640                1645            
Ile Lys Cys Glu Gln Leu Asn Leu Lys Ala Glu Gln Ser Lys Lys Glu
    1650                1655                1660                
Leu Asp Lys Val Val Thr Thr Ala Ile Lys Glu Glu Thr Glu Lys Val
1665                1670                1675                1680
Ala Ala Val Lys Gln Leu Glu Glu Ser Lys Thr Lys Ile Glu Asn Leu
                1685                1690                1695    
Leu Asp Trp Leu Ser Asn Val Asp Lys Asp Ser Glu Arg Ala Gly Thr
            1700                1705                1710        
Lys His Lys Gln Val Ile Glu Gln Asn Gly Thr His Phe Gln Glu Gly
        1715                1720                1725            
Asp Gly Lys Ser Ala Ile Gly Glu Glu Asp Glu Val Asn Gly Asn Leu
    1730                1735                1740                
Leu Glu Thr Asp Val Asp Gly Gln Val Gly Thr Thr Gln Glu Asn Leu
1745                1750                1755                1760
Asn Gln Gln Tyr Gln Lys Val Lys Ala Gln His Glu Lys Ile Ile Ser
                1765                1770                1775    
Gln His Gln Ala Val Ile Ile Ala Thr Gln Ser Ala Gln Val Leu Leu
            1780                1785                1790        
Glu Lys Gln Gly Gln Tyr Leu Ser Pro Glu Glu Lys Glu Lys Leu Gln
        1795                1800                1805            
Lys Asn Met Lys Glu Leu Lys Val His Tyr Glu Thr Ala Leu Ala Glu
    1810                1815                1820                
Ser Glu Lys Lys Met Lys Leu Thr His Ser Leu Gln Glu Glu Leu Glu
1825                1830                1835                1840
Lys Phe Asp Ala Asp Tyr Thr Glu Phe Glu His Trp Leu Gln Gln Ser
                1845                1850                1855    
Glu Gln Glu Leu Glu Asn Leu Glu Ala Gly Ala Asp Asp Ile Asn Gly
            1860                1865                1870        
Leu Met Thr Lys Leu Lys Arg Gln Lys Ser Phe Ser Glu Asp Val Ile
        1875                1880                1885            
Ser His Lys Gly Asp Leu Arg Tyr Ile Thr Ile Ser Gly Asn Arg Val
    1890                1895                1900                
Leu Glu Ala Ala Lys Ser Cys Ser Lys Arg Asp Gly Gly Lys Val Asp
1905                1910                1915                1920
Thr Ser Ala Thr His Arg Glu Val Gln Arg Lys Leu Asp His Ala Thr
                1925                1930                1935    
Asp Arg Phe Arg Ser Leu Tyr Ser Lys Cys Asn Val Leu Gly Asn Asn
            1940                1945                1950        
Leu Lys Asp Leu Val Asp Lys Tyr Gln His Tyr Glu Asp Ala Ser Cys
        1955                1960                1965            
Gly Leu Leu Ala Gly Leu Gln Ala Cys Glu Ala Thr Ala Ser Lys His
    1970                1975                1980                
Leu Ser Glu Pro Ile Ala Val Asp Pro Lys Asn Leu Gln Arg Gln Leu
1985                1990                1995                2000
Glu Glu Thr Lys Ala Leu Gln Gly Gln Ile Ser Ser Gln Gln Val Ala
                2005                2010                2015    
Val Glu Lys Leu Lys Lys Thr Ala Glu Val Leu Leu Asp Ala Arg Gly
            2020                2025                2030        
Ser Leu Leu Pro Ala Lys Asn Asp Ile Gln Lys Thr Leu Asp Asp Ile
        2035                2040                2045            
Val Gly Arg Tyr Glu Asp Leu Ser Lys Ser Val Asn Glu Arg Asn Glu
    2050                2055                2060                
Lys Leu Gln Ile Thr Leu Thr Arg Ser Leu Ser Val Gln Asp Gly Leu
2065                2070                2075                2080
Asp Glu Met Leu Asp Trp Met Gly Asn Val Glu Ser Ser Leu Lys Glu
                2085                2090                2095    
Gln Gly Gln Val Pro Leu Asn Ser Thr Ala Leu Gln Asp Ile Ile Ser
            2100                2105                2110        
Lys Asn Ile Met Leu Glu Gln Asp Ile Ala Gly Arg Gln Ser Ser Ile
        2115                2120                2125            
Asn Ala Met Asn Glu Lys Val Lys Lys Phe Met Glu Thr Thr Asp Pro
    2130                2135                2140                
Ser Thr Ala Ser Ser Leu Gln Ala Lys Met Lys Asp Leu Ser Ala Arg
2145                2150                2155                2160
Phe Ser Glu Ala Ser His Lys His Lys Glu Thr Leu Ala Lys Met Glu
                2165                2170                2175    
Glu Leu Lys Thr Lys Val Glu Leu Phe Glu Asn Leu Ser Glu Lys Leu
            2180                2185                2190        
Gln Thr Phe Leu Glu Thr Lys Thr Gln Ala Leu Thr Glu Val Asp Val
        2195                2200                2205            
Pro Gly Lys Asp Val Thr Glu Leu Ser Gln Tyr Met Gln Glu Ser Thr
    2210                2215                2220                
Ser Glu Phe Leu Glu His Lys Lys His Leu Glu Val Leu His Ser Leu
2225                2230                2235                2240
Leu Lys Glu Ile Ser Ser His Gly Leu Pro Ser Asp Lys Ala Leu Val
                2245                2250                2255    
Leu Glu Lys Thr Asn Asn Leu Ser Lys Lys Phe Lys Glu Met Glu Asp
            2260                2265                2270        
Thr Ile Lys Glu Lys Lys Glu Ala Val Thr Ser Cys Gln Glu Gln Leu
        2275                2280                2285            
Asp Ala Phe Gln Val Leu Val Lys Ser Leu Lys Ser Trp Ile Lys Glu
    2290                2295                2300                
Thr Thr Lys Lys Val Pro Ile Val Gln Pro Ser Phe Gly Ala Glu Asp
2305                2310                2315                2320
Leu Gly Lys Ser Leu Glu Asp Thr Lys Lys Leu Gln Glu Lys Trp Ser
                2325                2330                2335    
Leu Lys Thr Pro Glu Ile Gln Lys Val Asn Asn Ser Gly Ile Ser Leu
            2340                2345                2350        
Cys Asn Leu Ile Ser Ala Val Thr Thr Pro Ala Lys Ala Ile Ala Ala
        2355                2360                2365            
Val Lys Ser Gly Gly Ala Val Leu Asn Gly Glu Gly Thr Ala Thr Asn
    2370                2375                2380                
Thr Glu Glu Phe Trp Ala Asn Lys Gly Leu Thr Ser Ile Lys Lys Asp
2385                2390                2395                2400
Met Thr Asp Ile Ser His Gly Tyr Glu Asp Leu Gly Leu Leu Leu Lys
                2405                2410                2415    
Asp Lys Ile Ala Glu Leu Asn Thr Lys Leu Ser Lys Leu Gln Lys Ala
            2420                2425                2430        
Gln Glu Glu Ser Ser Ala Met Met Gln Trp Leu Gln Lys Met Asn Lys
        2435                2440                2445            
Thr Ala Thr Lys Trp Gln Gln Thr Pro Ala Pro Thr Asp Thr Glu Ala
    2450                2455                2460                
Val Lys Thr Gln Val Glu Gln Asn Lys Ser Phe Glu Ala Glu Leu Lys
2465                2470                2475                2480
Gln Asn Val Asn Lys Val Gln Glu Leu Lys Asp Lys Leu Thr Glu Leu
                2485                2490                2495    
Leu Glu Glu Asn Pro Asp Thr Pro Glu Ala Pro Arg Trp Lys Gln Met
            2500                2505                2510        
Leu Thr Glu Ile Asp Ser Lys Trp Gln Glu Leu Asn Gln Leu Thr Ile
        2515                2520                2525            
Asp Arg Gln Gln Lys Leu Glu Glu Ser Ser Asn Asn Leu Thr Gln Phe
    2530                2535                2540                
Gln Thr Val Glu Ala Gln Leu Lys Gln Trp Leu Val Glu Lys Glu Leu
2545                2550                2555                2560
Met Val Ser Val Leu Gly Pro Leu Ser Ile Asp Pro Asn Met Leu Asn
                2565                2570                2575    
Thr Gln Arg Gln Gln Val Gln Ile Leu Leu Gln Glu Phe Ala Thr Arg
            2580                2585                2590        
Lys Pro Gln Tyr Glu Gln Leu Thr Ala Ala Gly Gln Gly Ile Leu Ser
        2595                2600                2605            
Arg Pro Gly Glu Asp Pro Ser Leu Arg Gly Ile Val Lys Glu Gln Leu
    2610                2615                2620                
Ala Ala Val Thr Gln Lys Trp Asp Ser Leu Thr Gly Gln Leu Ser Asp
2625                2630                2635                2640
Arg Cys Asp Trp Ile Asp Gln Ala Ile Val Lys Ser Thr Gln Tyr Gln
                2645                2650                2655    
Ser Leu Leu Arg Ser Leu Ser Asp Lys Leu Ser Asp Leu Asp Asn Lys
            2660                2665                2670        
Leu Ser Ser Ser Leu Ala Val Ser Thr His Pro Asp Ala Met Asn Gln
        2675                2680                2685            
Gln Leu Glu Thr Ala Gln Lys Met Lys Gln Glu Ile Gln Gln Glu Lys
    2690                2695                2700                
Lys Gln Ile Lys Val Ala Gln Ala Leu Cys Glu Asp Leu Ser Ala Leu
2705                2710                2715                2720
Val Lys Glu Glu Tyr Leu Lys Ala Glu Leu Ser Arg Gln Leu Glu Gly
                2725                2730                2735    
Ile Leu Lys Ser Phe Lys Asp Val Glu Gln Lys Ala Glu Asn His Val
            2740                2745                2750        
Gln His Leu Gln Ser Ala Cys Ala Ser Ser His Gln Phe Gln Gln Met
        2755                2760                2765            
Ser Arg Asp Phe Gln Ala Trp Leu Asp Thr Lys Lys Glu Glu Gln Asn
    2770                2775                2780                
Lys Ser His Pro Ile Ser Ala Lys Leu Asp Val Leu Glu Ser Leu Ile
2785                2790                2795                2800
Lys Asp His Lys Asp Phe Ser Lys Thr Leu Thr Ala Gln Ser His Met
                2805                2810                2815    
Tyr Glu Lys Thr Ile Ala Glu Gly Glu Asn Leu Leu Leu Lys Thr Gln
            2820                2825                2830        
Gly Ser Glu Lys Ala Ala Leu Gln Leu Gln Leu Asn Thr Ile Lys Thr
        2835                2840                2845            
Asn Trp Asp Thr Phe Asn Lys Gln Val Lys Glu Arg Glu Asn Lys Leu
    2850                2855                2860                
Lys Glu Ser Leu Glu Lys Ala Leu Lys Tyr Lys Glu Gln Val Glu Thr
2865                2870                2875                2880
Leu Trp Pro Trp Ile Asp Lys Cys Gln Asn Asn Leu Glu Glu Ile Lys
                2885                2890                2895    
Phe Cys Leu Asp Pro Ala Glu Gly Glu Asn Ser Ile Ala Lys Leu Lys
            2900                2905                2910        
Ser Leu Gln Lys Glu Met Asp Gln His Phe Gly Met Val Glu Leu Leu
        2915                2920                2925            
Asn Asn Thr Ala Asn Ser Leu Leu Ser Val Cys Glu Ile Asp Lys Glu
    2930                2935                2940                
Val Val Thr Asp Glu Asn Lys Ser Leu Ile Gln Lys Val Asp Met Val
2945                2950                2955                2960
Thr Glu Gln Leu His Ser Lys Lys Phe Cys Leu Glu Asn Met Thr Gln
                2965                2970                2975    
Lys Phe Lys Glu Phe Gln Glu Val Ser Lys Glu Ser Lys Arg Gln Leu
            2980                2985                2990        
Gln Cys Ala Lys Glu Gln Leu Asp Ile His Asp Ser Leu Gly Ser Gln
        2995                3000                3005            
Ala Tyr Ser Asn Lys Tyr Leu Thr Met Leu Gln Thr Gln Gln Lys Ser
    3010                3015                3020                
Leu Gln Ala Leu Lys His Gln Val Asp Leu Ala Lys Arg Leu Ala Gln
3025                3030                3035                3040
Asp Leu Val Val Glu Ala Ser Asp Ser Lys Gly Thr Ser Asp Val Leu
                3045                3050                3055    
Leu Gln Val Glu Thr Ile Ala Gln Glu His Ser Thr Leu Ser Gln Gln
            3060                3065                3070        
Val Asp Glu Lys Cys Ser Phe Leu Glu Thr Lys Leu Gln Gly Ile Gly
        3075                3080                3085            
His Phe Gln Asn Thr Ile Arg Glu Met Phe Ser Gln Phe Ala Glu Phe
    3090                3095                3100                
Asp Asp Glu Leu Asp Ser Met Ala Pro Val Gly Arg Asp Ala Glu Thr
3105                3110                3115                3120
Leu Gln Lys Gln Lys Glu Thr Ile Lys Ala Phe Leu Lys Lys Leu Glu
                3125                3130                3135    
Ala Leu Met Ala Ser Asn Asp Asn Ala Asn Lys Thr Cys Lys Met Met
            3140                3145                3150        
Leu Ala Thr Glu Glu Thr Ser Pro Asp Leu Val Gly Ile Lys Arg Asp
        3155                3160                3165            
Leu Glu Ala Leu Ser Lys Gln Cys Asn Lys Leu Leu Asp Arg Ala Gln
    3170                3175                3180                
Ala Arg Glu Glu Gln Val Glu Gly Thr Ile Lys Arg Leu Glu Glu Phe
3185                3190                3195                3200
Tyr Ser Lys Leu Lys Glu Phe Ser Ile Leu Leu Gln Lys Ala Glu Glu
                3205                3210                3215    
His Glu Glu Ser Gln Gly Pro Val Gly Met Glu Thr Glu Thr Ile Asn
            3220                3225                3230        
Gln Gln Leu Asn Met Phe Lys Val Phe Gln Lys Glu Glu Ile Glu Pro
        3235                3240                3245            
Leu Gln Gly Lys Gln Gln Asp Val Asn Trp Leu Gly Gln Gly Leu Ile
    3250                3255                3260                
Gln Ser Ala Ala Lys Ser Thr Ser Thr Gln Gly Leu Glu His Asp Leu
3265                3270                3275                3280
Asp Asp Val Asn Ala Arg Trp Lys Thr Leu Asn Lys Lys Val Ala Gln
                3285                3290                3295    
Arg Ala Ala Gln Leu Gln Glu Ala Leu Leu His Cys Gly Arg Phe Gln
            3300                3305                3310        
Asp Ala Leu Glu Ser Leu Leu Ser Trp Met Val Asp Thr Glu Glu Leu
        3315                3320                3325            
Val Ala Asn Gln Lys Pro Pro Ser Ala Glu Phe Lys Val Val Lys Ala
    3330                3335                3340                
Gln Ile Gln Glu Gln Lys Leu Leu Gln Arg Leu Leu Asp Asp Arg Lys
3345                3350                3355                3360
Ser Thr Val Glu Val Ile Lys Arg Glu Gly Glu Lys Ile Ala Thr Thr
                3365                3370                3375    
Ala Glu Pro Ala Asp Lys Val Lys Ile Leu Lys Gln Leu Ser Leu Leu
            3380                3385                3390        
Asp Ser Arg Trp Glu Ala Leu Leu Asn Lys Ala Glu Thr Arg Asn Arg
        3395                3400                3405            
Gln Leu Glu Gly Ile Ser Val Val Ala Gln Gln Phe His Glu Thr Leu
    3410                3415                3420                
Glu Pro Leu Asn Glu Trp Leu Thr Thr Ile Glu Lys Arg Leu Val Asn
3425                3430                3435                3440
Cys Glu Pro Ile Gly Thr Gln Ala Ser Lys Leu Glu Glu Gln Ile Ala
                3445                3450                3455    
Gln His Lys Ala Leu Glu Asp Asp Ile Ile Asn His Asn Lys His Leu
            3460                3465                3470        
His Gln Ala Val Ser Ile Gly Gln Ser Leu Lys Val Leu Ser Ser Arg
        3475                3480                3485            
Glu Asp Lys Asp Met Val Gln Ser Lys Leu Asp Phe Ser Gln Val Trp
    3490                3495                3500                
Tyr Ile Glu Ile Gln Glu Lys Ser His Ser Arg Ser Glu Leu Leu Gln
3505                3510                3515                3520
Gln Ala Leu Cys Asn Ala Lys Ile Phe Gly Glu Asp Glu Val Glu Leu
                3525                3530                3535    
Met Asn Trp Leu Asn Glu Val His Asp Lys Leu Ser Lys Leu Ser Val
            3540                3545                3550        
Gln Asp Tyr Ser Thr Glu Gly Leu Trp Lys Gln Gln Ser Glu Leu Arg
        3555                3560                3565            
Val Leu Gln Glu Asp Ile Leu Leu Arg Lys Gln Asn Val Asp Gln Ala
    3570                3575                3580                
Leu Leu Asn Gly Leu Glu Leu Leu Lys Gln Thr Thr Gly Asp Glu Val
3585                3590                3595                3600
Leu Ile Ile Gln Asp Lys Leu Glu Ala Ile Lys Ala Arg Tyr Lys Asp
                3605                3610                3615    
Ile Thr Lys Leu Ser Thr Asp Val Ala Lys Thr Leu Glu Gln Ala Leu
            3620                3625                3630        
Gln Leu Ala Arg Arg Leu His Ser Thr His Glu Glu Leu Cys Thr Trp
        3635                3640                3645            
Leu Asp Lys Val Glu Val Glu Leu Leu Ser Tyr Glu Thr Gln Val Leu
    3650                3655                3660                
Lys Gly Glu Glu Ala Ser Gln Ala Gln Met Arg Pro Lys Glu Leu Lys
3665                3670                3675                3680
Lys Glu Ala Lys Asn Asn Lys Ala Leu Leu Asp Ser Leu Asn Glu Val
                3685                3690                3695    
Ser Ser Ala Leu Leu Glu Leu Val Pro Trp Arg Ala Arg Glu Gly Leu
            3700                3705                3710        
Glu Lys Met Val Ala Glu Asp Asn Glu Arg Tyr Arg Leu Val Ser Asp
        3715                3720                3725            
Thr Ile Thr Gln Lys Val Glu Glu Ile Asp Ala Ala Ile Leu Arg Ser
    3730                3735                3740                
Gln Gln Phe Asp Gln Ala Ala Asp Ala Glu Leu Ser Trp Ile Thr Glu
3745                3750                3755                3760
Thr Glu Lys Lys Leu Met Ser Leu Gly Asp Ile Arg Leu Glu Gln Asp
                3765                3770                3775    
Gln Thr Ser Ala Gln Leu Gln Val Gln Lys Thr Phe Thr Met Glu Ile
            3780                3785                3790        
Leu Arg His Lys Asp Ile Ile Asp Asp Leu Val Lys Ser Gly His Lys
        3795                3800                3805            
Ile Met Thr Ala Cys Ser Glu Glu Glu Lys Gln Ser Met Lys Lys Lys
    3810                3815                3820                
Leu Asp Lys Val Leu Lys Asn Tyr Asp Thr Ile Cys Gln Ile Asn Ser
3825                3830                3835                3840
Glu Arg Tyr Leu Gln Leu Glu Arg Ala Gln Ser Leu Val Asn Gln Phe
                3845                3850                3855    
Trp Glu Thr Tyr Glu Glu Leu Trp Pro Trp Leu Thr Glu Thr Gln Ser
            3860                3865                3870        
Ile Ile Ser Gln Leu Pro Ala Pro Ala Leu Glu Tyr Glu Thr Leu Arg
        3875                3880                3885            
Gln Gln Gln Glu Glu His Arg Gln Leu Arg Glu Leu Ile Ala Glu His
    3890                3895                3900                
Lys Pro His Ile Asp Lys Met Asn Lys Thr Gly Pro Gln Leu Leu Glu
3905                3910                3915                3920
Leu Ser Pro Gly Glu Gly Phe Ser Ile Gln Glu Lys Tyr Val Ala Ala
                3925                3930                3935    
Asp Thr Leu Tyr Ser Gln Ile Lys Glu Asp Val Lys Lys Arg Ala Val
            3940                3945                3950        
Ala Leu Asp Glu Ala Ile Ser Gln Ser Thr Gln Phe His Asp Lys Ile
        3955                3960                3965            
Asp Gln Ile Leu Glu Ser Leu Glu Arg Ile Val Glu Arg Leu Arg Gln
    3970                3975                3980                
Pro Pro Ser Ile Ser Ala Glu Val Glu Lys Ile Lys Glu Gln Ile Ser
3985                3990                3995                4000
Glu Asn Lys Asn Val Ser Val Asp Met Glu Lys Leu Gln Pro Leu Tyr
                4005                4010                4015    
Glu Thr Leu Lys Gln Arg Gly Glu Glu Met Ile Ala Arg Ser Gly Gly
            4020                4025                4030        
Thr Asp Lys Asp Ile Ser Ala Lys Ala Val Gln Asp Lys Leu Asp Gln
        4035                4040                4045            
Met Val Phe Ile Trp Glu Asn Ile His Thr Leu Val Glu Glu Arg Glu
    4050                4055                4060                
Ala Lys Leu Leu Asp Val Met Glu Leu Ala Glu Lys Phe Trp Cys Asp
4065                4070                4075                4080
His Met Ser Leu Ile Val Thr Ile Lys Asp Thr Gln Asp Phe Ile Arg
                4085                4090                4095    
Asp Leu Glu Asp Pro Gly Ile Asp Pro Ser Val Val Lys Gln Gln Gln
            4100                4105                4110        
Glu Ala Ala Glu Thr Ile Arg Glu Glu Ile Asp Gly Leu Gln Glu Glu
        4115                4120                4125            
Leu Asp Ile Val Ile Asn Leu Gly Ser Glu Leu Ile Ala Ala Cys Gly
    4130                4135                4140                
Glu Pro Asp Lys Pro Ile Val Lys Lys Ser Ile Asp Glu Leu Asn Ser
4145                4150                4155                4160
Ala Trp Asp Ser Leu Asn Lys Ala Trp Lys Asp Arg Ile Asp Lys Leu
                4165                4170                4175    
Glu Glu Ala Met Gln Ala Ala Val Gln Tyr Gln Asp Gly Leu Gln Ala
            4180                4185                4190        
Val Phe Asp Trp Val Asp Ile Ala Gly Gly Lys Leu Ala Ser Met Ser
        4195                4200                4205            
Pro Ile Gly Thr Asp Leu Glu Thr Val Lys Gln Gln Ile Glu Glu Leu
    4210                4215                4220                
Lys Gln Phe Lys Ser Glu Ala Tyr Gln Gln Gln Ile Glu Met Glu Arg
4225                4230                4235                4240
Leu Asn His Gln Ala Glu Leu Leu Leu Lys Lys Val Thr Glu Glu Ser
                4245                4250                4255    
Asp Lys His Thr Val Gln Asp Pro Leu Met Glu Leu Lys Leu Ile Trp
            4260                4265                4270        
Asp Ser Leu Glu Glu Arg Ile Ile Asn Arg Gln His Lys Leu Glu Gly
        4275                4280                4285            
Ala Leu Leu Ala Leu Gly Gln Phe Gln His Ala Leu Asp Glu Leu Leu
    4290                4295                4300                
Ala Trp Leu Thr His Thr Glu Gly Leu Leu Ser Glu Gln Lys Pro Val
4305                4310                4315                4320
Gly Gly Asp Pro Lys Ala Ile Glu Ile Glu Leu Ala Lys His His Val
                4325                4330                4335    
Leu Gln Asn Asp Val Leu Ala His Gln Ser Thr Val Glu Ala Val Asn
            4340                4345                4350        
Lys Ala Gly Asn Asp Leu Ile Glu Ser Ser Ala Gly Glu Glu Ala Ser
        4355                4360                4365            
Asn Leu Gln Asn Lys Leu Glu Val Leu Asn Gln Arg Trp Gln Asn Val
    4370                4375                4380                
Leu Glu Lys Thr Glu Gln Arg Lys Gln Gln Leu Asp Gly Ala Leu Arg
4385                4390                4395                4400
Gln Ala Lys Gly Phe His Gly Glu Ile Glu Asp Leu Gln Gln Trp Leu
                4405                4410                4415    
Thr Asp Thr Glu Arg His Leu Leu Ala Ser Lys Pro Leu Gly Gly Leu
            4420                4425                4430        
Pro Glu Thr Ala Lys Glu Gln Leu Asn Val His Met Glu Val Cys Ala
        4435                4440                4445            
Ala Phe Glu Ala Lys Glu Glu Thr Tyr Lys Ser Leu Met Gln Lys Gly
    4450                4455                4460                
Gln Gln Met Leu Ala Arg Cys Pro Lys Ser Ala Glu Thr Asn Ile Asp
4465                4470                4475                4480
Gln Asp Ile Asn Asn Leu Lys Glu Lys Trp Glu Ser Val Glu Thr Lys
                4485                4490                4495    
Leu Asn Glu Arg Lys Thr Lys Leu Glu Glu Ala Leu Asn Leu Ala Met
            4500                4505                4510        
Glu Phe His Asn Ser Leu Gln Asp Phe Ile Asn Trp Leu Thr Gln Ala
        4515                4520                4525            
Glu Gln Thr Leu Asn Val Ala Ser Arg Pro Ser Leu Ile Leu Asp Thr
    4530                4535                4540                
Val Leu Phe Gln Ile Asp Glu His Lys Val Phe Ala Asn Glu Val Asn
4545                4550                4555                4560
Ser His Arg Glu Gln Ile Ile Glu Leu Asp Lys Thr Gly Thr His Leu
                4565                4570                4575    
Lys Tyr Phe Ser Gln Lys Gln Asp Val Val Leu Ile Lys Asn Leu Leu
            4580                4585                4590        
Ile Ser Val Gln Ser Arg Trp Glu Lys Val Val Gln Arg Leu Val Glu
        4595                4600                4605            
Arg Gly Arg Ser Leu Asp Asp Ala Arg Lys Arg Ala Lys Gln Phe His
    4610                4615                4620                
Glu Ala Trp Ser Lys Leu Met Glu Trp Leu Glu Glu Ser Glu Lys Ser
4625                4630                4635                4640
Leu Asp Ser Glu Leu Glu Ile Ala Asn Asp Pro Asp Lys Ile Lys Thr
                4645                4650                4655    
Gln Leu Ala Gln His Lys Glu Phe Gln Lys Ser Leu Gly Ala Lys His
            4660                4665                4670        
Ser Val Tyr Asp Thr Thr Asn Arg Thr Gly Arg Ser Leu Lys Glu Lys
        4675                4680                4685            
Thr Ser Leu Ala Asp Asp Asn Leu Lys Leu Asp Asp Met Leu Ser Glu
    4690                4695                4700                
Leu Arg Asp Lys Trp Asp Thr Ile Cys Gly Lys Ser Val Glu Arg Gln
4705                4710                4715                4720
Asn Lys Leu Glu Glu Ala Leu Leu Phe Ser Gly Gln Phe Thr Asp Ala
                4725                4730                4735    
Leu Gln Ala Leu Ile Asp Trp Leu Tyr Arg Val Glu Pro Gln Leu Ala
            4740                4745                4750        
Glu Asp Gln Pro Val His Gly Asp Ile Asp Leu Val Met Asn Leu Ile
        4755                4760                4765            
Asp Asn His Lys Ala Phe Gln Lys Glu Leu Gly Lys Arg Thr Ser Ser
    4770                4775                4780                
Val Gln Ala Leu Lys Arg Ser Ala Arg Glu Leu Ile Glu Gly Ser Arg
4785                4790                4795                4800
Asp Asp Ser Ser Trp Val Lys Val Gln Met Gln Glu Leu Ser Thr Arg
                4805                4810                4815    
Trp Glu Thr Val Cys Ala Leu Ser Ile Ser Lys Gln Thr Arg Leu Glu
            4820                4825                4830        
Ala Ala Leu Arg Gln Ala Glu Glu Phe His Ser Val Val His Ala Leu
        4835                4840                4845            
Leu Glu Trp Leu Ala Glu Ala Glu Gln Thr Leu Arg Phe His Gly Val
    4850                4855                4860                
Leu Pro Asp Asp Glu Asp Ala Leu Arg Thr Leu Ile Asp Gln His Lys
4865                4870                4875                4880
Glu Phe Met Lys Lys Leu Glu Glu Lys Arg Ala Glu Leu Asn Lys Ala
                4885                4890                4895    
Thr Thr Met Gly Asp Thr Val Leu Ala Ile Cys His Pro Asp Ser Ile
            4900                4905                4910        
Thr Thr Ile Lys His Trp Ile Thr Ile Ile Arg Ala Arg Phe Glu Glu
        4915                4920                4925            
Val Leu Ala Trp Ala Lys Gln His Gln Gln Arg Leu Ala Ser Ala Leu
    4930                4935                4940                
Ala Gly Leu Ile Ala Lys Gln Glu Leu Leu Glu Ala Leu Leu Ala Trp
4945                4950                4955                4960
Leu Gln Trp Ala Glu Thr Thr Leu Thr Asp Lys Asp Lys Glu Val Ile
                4965                4970                4975    
Pro Gln Glu Ile Glu Glu Val Lys Ala Leu Ile Ala Glu His Gln Thr
            4980                4985                4990        
Phe Met Glu Glu Met Thr Arg Lys Gln Pro Asp Val Asp Lys Val Thr
        4995                5000                5005            
Lys Thr Tyr Lys Arg Arg Ala Ala Asp Pro Ser Ser Leu Gln Ser His
    5010                5015                5020                
Ile Pro Val Leu Asp Lys Gly Arg Ala Gly Arg Lys Arg Phe Pro Ala
5025                5030                5035                5040
Ser Ser Leu Tyr Pro Ser Gly Ser Gln Thr Gln Ile Glu Thr Lys Asn
                5045                5050                5055    
Pro Arg Val Asn Leu Leu Val Ser Lys Trp Gln Gln Val Trp Leu Leu
            5060                5065                5070        
Ala Leu Glu Arg Arg Arg Lys Leu Asn Asp Ala Leu Asp Arg Leu Glu
        5075                5080                5085            
Glu Leu Arg Glu Phe Ala Asn Phe Asp Phe Asp Ile Trp Arg Lys Lys
    5090                5095                5100                
Tyr Met Arg Trp Met Asn His Lys Lys Ser Arg Val Met Asp Phe Phe
5105                5110                5115                5120
Arg Arg Ile Asp Lys Asp Gln Asp Gly Lys Ile Thr Arg Gln Glu Phe
                5125                5130                5135    
Ile Asp Gly Ile Leu Ser Ser Lys Phe Pro Thr Ser Arg Leu Glu Met
            5140                5145                5150        
Ser Ala Val Ala Asp Ile Phe Asp Arg Asp Gly Asp Gly Tyr Ile Asp
        5155                5160                5165            
Tyr Tyr Glu Phe Val Ala Ala Leu His Pro Asn Lys Asp Ala Tyr Lys
    5170                5175                5180                
Pro Ile Thr Asp Ala Asp Lys Ile Glu Asp Glu Val Thr Arg Gln Val
5185                5190                5195                5200
Ala Lys Cys Lys Cys Ala Lys Arg Phe Gln Val Glu Gln Ile Gly Asp
                5205                5210                5215    
Asn Lys Tyr Arg Phe Phe Leu Gly Asn Gln Phe Gly Asp Ser Gln Gln
            5220                5225                5230        
Leu Arg Leu Val Arg Ile Leu Arg Ser Thr Val Met Val Arg Val Gly
        5235                5240                5245            
Gly Gly Trp Met Ala Leu Asp Glu Phe Leu Val Lys Asn Asp Pro Cys
    5250                5255                5260                
Arg Ala Lys Gly Arg Thr Asn Met Glu Leu Arg Glu Lys Phe Ile Leu
5265                5270                5275                5280
Ala Asp Gly Ala Ser Gln Gly Met Ala Ala Phe Arg Pro Arg Gly Arg
                5285                5290                5295    
Arg Ser Arg Pro Ser Ser Arg Gly Ala Ser Pro Asn Arg Ser Thr Ser
            5300                5305                5310        
Val Ser Ser Gln Ala Ala Gln Ala Ala Ser Pro Gln Val Pro Ala Thr
        5315                5320                5325            
Thr Thr Pro Lys Ile Leu His Pro Leu Thr Arg Asn Tyr Gly Lys Pro
    5330                5335                5340                
Trp Leu Thr Asn Ser Lys Met Ser Thr Pro Cys Lys Ala Ala Glu Cys
5345                5350                5355                5360
Ser Asp Phe Pro Val Pro Ser Ala Glu Gly Thr Pro Ile Gln Gly Ser
                5365                5370                5375    
Lys Leu Arg Leu Pro Gly Tyr Leu Ser Gly Lys Gly Phe His Ser Gly
            5380                5385                5390        
Glu Asp Ser Gly Leu Ile Thr Thr Ala Ala Ala Arg Val Arg Thr Gln
        5395                5400                5405            
Phe Ala Asp Ser Lys Lys Thr Pro Ser Arg Pro Gly Ser Arg Ala Gly
    5410                5415                5420                
Ser Lys Ala Gly Ser Arg Ala Ser Ser Arg Arg Gly Ser Asp Ala Ser
5425                5430                5435                5440
Asp Phe Asp Ile Ser Glu Ile Gln Ser Val Cys Ser Asp Val Glu Thr
                5445                5450                5455    
Val Pro Gln Thr His Arg Pro Thr Pro Arg Ala Gly Ser Arg Pro Ser
            5460                5465                5470        
Thr Ala Lys Pro Ser Lys Ile Pro Thr Pro Gln Arg Lys Ser Pro Ala
        5475                5480                5485            
Ser Lys Leu Asp Lys Ser Ser Lys Arg
    5490                5495        


<210> 7949
<211> 351
<212> PRT
<213> Homo sapiens

<400> 7949
Met Ala Leu Pro Phe Gln Lys Glu Leu Glu Lys Tyr Lys Asn Ile Asp
 1               5                  10                  15      
Glu Asp Glu Leu Leu Gly Lys Leu Ser Glu Glu Glu Leu Lys Gln Leu
            20                  25                  30          
Glu Asn Val Leu Asp Asp Leu Asp Pro Glu Ser Ala Met Leu Pro Ala
        35                  40                  45              
Gly Phe Arg Gln Lys Asp Gln Thr Gln Lys Ala Ala Thr Gly Pro Phe
    50                  55                  60                  
Asp Arg Glu His Leu Leu Met Tyr Leu Glu Lys Glu Ala Leu Glu Gln
65                  70                  75                  80  
Lys Asp Arg Glu Asp Phe Val Pro Phe Thr Gly Glu Lys Lys Gly Arg
                85                  90                  95      
Val Phe Ile Pro Lys Glu Lys Pro Ile Glu Thr Arg Lys Glu Glu Lys
            100                 105                 110         
Val Thr Leu Asp Pro Glu Leu Glu Glu Ala Leu Ala Ser Ala Ser Asp
        115                 120                 125             
Thr Glu Leu Tyr Asp Leu Ala Ala Val Leu Gly Val His Asn Leu Leu
    130                 135                 140                 
Asn Asn Pro Lys Phe Asp Glu Glu Thr Ala Asn Asn Lys Gly Gly Lys
145                 150                 155                 160 
Gly Pro Val Arg Asn Val Val Lys Gly Glu Lys Val Lys Pro Val Phe
                165                 170                 175     
Glu Glu Pro Pro Asn Pro Thr Asn Val Glu Ile Ser Leu Gln Gln Met
            180                 185                 190         
Lys Ala Asn Asp Pro Ser Leu Gln Glu Val Asn Leu Asn Asn Ile Lys
        195                 200                 205             
Asn Ile Pro Ile Pro Thr Leu Arg Glu Phe Ala Lys Ala Leu Glu Thr
    210                 215                 220                 
Asn Thr His Val Lys Lys Phe Ser Leu Ala Ala Thr Arg Ser Asn Asp
225                 230                 235                 240 
Pro Val Ala Ile Ala Phe Ala Asp Met Leu Lys Val Asn Lys Thr Leu
                245                 250                 255     
Thr Ser Leu Asn Ile Glu Ser Asn Phe Ile Thr Gly Thr Gly Ile Leu
            260                 265                 270         
Ala Leu Val Glu Ala Leu Lys Glu Asn Asp Thr Leu Thr Glu Ile Lys
        275                 280                 285             
Ile Asp Asn Gln Arg Gln Gln Leu Gly Thr Ala Val Glu Met Glu Ile
    290                 295                 300                 
Ala Gln Met Leu Glu Glu Asn Ser Arg Ile Leu Lys Phe Gly Tyr Gln
305                 310                 315                 320 
Phe Thr Lys Gln Gly Pro Arg Thr Arg Val Ala Ala Ala Ile Thr Lys
                325                 330                 335     
Asn Asn Asp Leu Val Arg Lys Lys Arg Val Glu Ala Asp Arg Arg
            340                 345                 350     


<210> 7950
<211> 777
<212> PRT
<213> Homo sapiens

<400> 7950
Met Ser Gly Ser His Thr Pro Ala Cys Gly Pro Phe Ser Ala Leu Thr
 1               5                  10                  15      
Pro Ser Ile Trp Pro Gln Glu Ile Leu Ala Lys Tyr Thr Gln Lys Glu
            20                  25                  30          
Glu Ser Ala Glu Gln Pro Glu Phe Tyr Tyr Asp Glu Phe Gly Phe Arg
        35                  40                  45              
Val Tyr Lys Glu Glu Gly Asp Glu Pro Gly Ser Ser Leu Leu Ala Asn
    50                  55                  60                  
Ser Pro Leu Met Glu Asp Ala Pro Gln Arg Leu Arg Trp Gln Ala His
65                  70                  75                  80  
Leu Glu Phe Thr His Asn His Asp Val Gly Asp Leu Thr Trp Asp Lys
                85                  90                  95      
Ile Ala Val Ser Leu Pro Arg Ser Glu Lys Leu Arg Ser Leu Val Leu
            100                 105                 110         
Ala Gly Ile Pro His Gly Met Arg Pro Gln Leu Trp Met Arg Leu Ser
        115                 120                 125             
Gly Ala Leu Gln Lys Lys Arg Asn Ser Glu Leu Ser Tyr Arg Glu Ile
    130                 135                 140                 
Val Lys Asn Ser Ser Asn Asp Glu Thr Ile Ala Ala Lys Gln Ile Glu
145                 150                 155                 160 
Lys Asp Leu Leu Arg Thr Met Pro Ser Asn Ala Cys Phe Ala Ser Met
                165                 170                 175     
Gly Ser Ile Gly Val Pro Arg Leu Arg Arg Val Leu Arg Ala Leu Ala
            180                 185                 190         
Trp Leu Tyr Pro Glu Ile Gly Tyr Cys Gln Gly Thr Gly Met Val Ala
        195                 200                 205             
Ala Cys Leu Leu Leu Phe Leu Glu Glu Glu Asp Ala Phe Trp Met Met
    210                 215                 220                 
Ser Ala Ile Ile Glu Asp Leu Leu Pro Ala Ser Tyr Phe Ser Thr Thr
225                 230                 235                 240 
Leu Leu Gly Val Gln Thr Asp Gln Arg Val Leu Arg His Leu Ile Val
                245                 250                 255     
Gln Tyr Leu Pro Arg Leu Asp Lys Leu Leu Gln Glu His Asp Ile Glu
            260                 265                 270         
Leu Ser Leu Ile Thr Leu His Trp Phe Leu Thr Ala Phe Ala Ser Val
        275                 280                 285             
Val Asp Ile Lys Leu Leu Leu Arg Ile Trp Asp Leu Phe Phe Tyr Glu
    290                 295                 300                 
Gly Ser Arg Val Leu Phe Gln Leu Thr Leu Gly Met Leu His Leu Lys
305                 310                 315                 320 
Glu Glu Glu Leu Ile Gln Ser Glu Asn Ser Ala Ser Ile Phe Asn Thr
                325                 330                 335     
Leu Ser Asp Ile Pro Ser Gln Met Glu Asp Ala Glu Leu Leu Leu Gly
            340                 345                 350         
Val Ala Met Arg Leu Ala Gly Ser Leu Thr Asp Val Ala Val Glu Thr
        355                 360                 365             
Gln Arg Arg Lys His Leu Ala Tyr Leu Ile Ala Asp Gln Gly Gln Leu
    370                 375                 380                 
Leu Gly Ala Gly Thr Leu Thr Asn Leu Ser Gln Val Val Arg Arg Arg
385                 390                 395                 400 
Thr Gln Arg Arg Lys Ser Thr Ile Thr Ala Leu Leu Phe Gly Glu Asp
                405                 410                 415     
Asp Leu Glu Ala Leu Lys Ala Lys Asn Ile Lys Gln Thr Glu Leu Val
            420                 425                 430         
Ala Asp Leu Arg Glu Ala Ile Leu Arg Val Ala Arg His Phe Gln Cys
        435                 440                 445             
Thr Asp Pro Lys Asn Cys Ser Val Val Ser Arg Gln Leu Pro Gly Leu
    450                 455                 460                 
Leu Pro Asn Thr Ala Leu Thr Pro Pro Thr Pro Leu Val Gly Leu Cys
465                 470                 475                 480 
Ser Leu Trp Gln Glu Leu Thr Pro Asp Tyr Ser Met Glu Ser His Gln
                485                 490                 495     
Arg Asp His Glu Asn Tyr Val Ala Cys Ser Arg Ser His Arg Arg Arg
            500                 505                 510         
Ala Lys Ala Leu Leu Asp Phe Glu Arg His Asp Asp Asp Glu Leu Gly
        515                 520                 525             
Phe Arg Lys Asn Asp Ile Ile Thr Ile Val Ser Gln Lys Asp Glu His
    530                 535                 540                 
Cys Trp Val Gly Glu Leu Asn Gly Leu Arg Gly Trp Phe Pro Ala Lys
545                 550                 555                 560 
Phe Val Glu Val Leu Asp Glu Arg Ser Lys Glu Tyr Ser Ile Ala Gly
                565                 570                 575     
Asp Asp Ser Val Thr Glu Gly Val Thr Asp Leu Val Arg Gly Thr Leu
            580                 585                 590         
Cys Pro Ala Leu Lys Ala Leu Phe Glu His Gly Leu Lys Lys Pro Ser
        595                 600                 605             
Leu Leu Gly Gly Ala Cys His Pro Trp Leu Phe Ile Glu Glu Ala Ala
    610                 615                 620                 
Gly Arg Glu Val Glu Arg Asp Phe Ala Ser Val Tyr Ser Arg Leu Val
625                 630                 635                 640 
Leu Cys Lys Thr Phe Arg Leu Asp Glu Asp Gly Lys Val Leu Thr Pro
                645                 650                 655     
Glu Glu Leu Leu Tyr Arg Ala Val Gln Ser Val Asn Val Thr His Asp
            660                 665                 670         
Ala Val His Ala Gln Met Asp Val Lys Leu Arg Ser Leu Ile Cys Val
        675                 680                 685             
Gly Leu Asn Glu Gln Val Leu His Leu Trp Leu Glu Val Leu Cys Ser
    690                 695                 700                 
Ser Leu Pro Thr Val Glu Lys Trp Tyr Gln Pro Trp Ser Phe Leu Arg
705                 710                 715                 720 
Ser Pro Gly Trp Val Gln Ile Lys Cys Glu Leu Arg Val Leu Cys Cys
                725                 730                 735     
Phe Ala Phe Ser Leu Ser Gln Asp Trp Glu Leu Pro Ala Lys Arg Glu
            740                 745                 750         
Ala Gln Gln Pro Leu Lys Glu Gly Val Arg Asp Met Leu Val Lys His
        755                 760                 765             
His Leu Phe Ser Trp Asp Val Asp Gly
    770                 775         


<210> 7951
<211> 749
<212> PRT
<213> Homo sapiens

<400> 7951
Met Ser Gly Ser His Thr Pro Ala Cys Gly Pro Phe Ser Ala Leu Thr
 1               5                  10                  15      
Pro Ser Ile Trp Pro Gln Glu Ile Leu Ala Lys Tyr Thr Gln Lys Glu
            20                  25                  30          
Glu Ser Ala Glu Gln Pro Glu Phe Tyr Tyr Asp Glu Phe Gly Phe Arg
        35                  40                  45              
Val Tyr Lys Glu Glu Gly Asp Glu Pro Gly Ser Ser Leu Leu Ala Asn
    50                  55                  60                  
Ser Pro Leu Met Glu Asp Ala Pro Gln Arg Leu Arg Trp Gln Ala His
65                  70                  75                  80  
Leu Glu Phe Thr His Asn His Asp Val Gly Asp Leu Thr Trp Asp Lys
                85                  90                  95      
Ile Ala Val Ser Leu Pro Arg Ser Glu Lys Leu Arg Ser Leu Val Leu
            100                 105                 110         
Ala Gly Ile Pro His Gly Met Arg Pro Gln Leu Trp Met Arg Leu Ser
        115                 120                 125             
Gly Ala Leu Gln Lys Lys Arg Asn Ser Glu Leu Ser Tyr Arg Glu Ile
    130                 135                 140                 
Val Lys Asn Ser Ser Asn Asp Glu Thr Ile Ala Ala Lys Gln Ile Glu
145                 150                 155                 160 
Lys Asp Leu Leu Arg Thr Met Pro Ser Asn Ala Cys Phe Ala Ser Met
                165                 170                 175     
Gly Ser Ile Gly Val Pro Arg Leu Arg Arg Val Leu Arg Ala Leu Ala
            180                 185                 190         
Trp Leu Tyr Pro Glu Ile Gly Tyr Cys Gln Gly Thr Gly Met Val Ala
        195                 200                 205             
Ala Cys Leu Leu Leu Phe Leu Glu Glu Glu Asp Ala Phe Trp Met Met
    210                 215                 220                 
Ser Ala Ile Ile Glu Asp Leu Leu Pro Ala Ser Tyr Phe Ser Thr Thr
225                 230                 235                 240 
Leu Leu Gly Val Gln Thr Asp Gln Arg Val Leu Arg His Leu Ile Val
                245                 250                 255     
Gln Tyr Leu Pro Arg Leu Asp Lys Leu Leu Gln Glu His Asp Ile Glu
            260                 265                 270         
Leu Ser Leu Ile Thr Leu His Trp Phe Leu Thr Ala Phe Ala Ser Val
        275                 280                 285             
Val Asp Ile Lys Leu Leu Leu Arg Ile Trp Asp Leu Phe Phe Tyr Glu
    290                 295                 300                 
Gly Ser Arg Val Leu Phe Gln Leu Thr Leu Gly Met Leu His Leu Lys
305                 310                 315                 320 
Glu Glu Glu Leu Ile Gln Ser Glu Asn Ser Ala Ser Ile Phe Asn Thr
                325                 330                 335     
Leu Ser Asp Ile Pro Ser Gln Met Glu Asp Ala Glu Leu Leu Leu Gly
            340                 345                 350         
Val Ala Met Arg Leu Ala Gly Ser Leu Thr Asp Val Ala Val Glu Thr
        355                 360                 365             
Gln Arg Arg Lys His Leu Ala Tyr Leu Ile Ala Asp Gln Gly Gln Leu
    370                 375                 380                 
Leu Gly Ala Gly Thr Leu Thr Asn Leu Ser Gln Val Val Arg Arg Arg
385                 390                 395                 400 
Thr Gln Arg Arg Lys Ser Thr Ile Thr Ala Leu Leu Phe Gly Glu Asp
                405                 410                 415     
Asp Leu Glu Ala Leu Lys Ala Lys Asn Ile Lys Gln Thr Glu Leu Val
            420                 425                 430         
Ala Asp Leu Arg Glu Ala Ile Leu Arg Val Ala Arg His Phe Gln Cys
        435                 440                 445             
Thr Asp Pro Lys Asn Cys Ser Val Glu Leu Thr Pro Asp Tyr Ser Met
    450                 455                 460                 
Glu Ser His Gln Arg Asp His Glu Asn Tyr Val Ala Cys Ser Arg Ser
465                 470                 475                 480 
His Arg Arg Arg Ala Lys Ala Leu Leu Asp Phe Glu Arg His Asp Asp
                485                 490                 495     
Asp Glu Leu Gly Phe Arg Lys Asn Asp Ile Ile Thr Ile Val Ser Gln
            500                 505                 510         
Lys Asp Glu His Cys Trp Val Gly Glu Leu Asn Gly Leu Arg Gly Trp
        515                 520                 525             
Phe Pro Ala Lys Phe Val Glu Val Leu Asp Glu Arg Ser Lys Glu Tyr
    530                 535                 540                 
Ser Ile Ala Gly Asp Asp Ser Val Thr Glu Gly Val Thr Asp Leu Val
545                 550                 555                 560 
Arg Gly Thr Leu Cys Pro Ala Leu Lys Ala Leu Phe Glu His Gly Leu
                565                 570                 575     
Lys Lys Pro Ser Leu Leu Gly Gly Ala Cys His Pro Trp Leu Phe Ile
            580                 585                 590         
Glu Glu Ala Ala Gly Arg Glu Val Glu Arg Asp Phe Ala Ser Val Tyr
        595                 600                 605             
Ser Arg Leu Val Leu Cys Lys Thr Phe Arg Leu Asp Glu Asp Gly Lys
    610                 615                 620                 
Val Leu Thr Pro Glu Glu Leu Leu Tyr Arg Ala Val Gln Ser Val Asn
625                 630                 635                 640 
Val Thr His Asp Ala Val His Ala Gln Met Asp Val Lys Leu Arg Ser
                645                 650                 655     
Leu Ile Cys Val Gly Leu Asn Glu Gln Val Leu His Leu Trp Leu Glu
            660                 665                 670         
Val Leu Cys Ser Ser Leu Pro Thr Val Glu Lys Trp Tyr Gln Pro Trp
        675                 680                 685             
Ser Phe Leu Arg Ser Pro Gly Trp Val Gln Ile Lys Cys Glu Leu Arg
    690                 695                 700                 
Val Leu Cys Cys Phe Ala Phe Ser Leu Ser Gln Asp Trp Glu Leu Pro
705                 710                 715                 720 
Ala Lys Arg Glu Ala Gln Gln Pro Leu Lys Glu Gly Val Arg Asp Met
                725                 730                 735     
Leu Val Lys His His Leu Phe Ser Trp Asp Val Asp Gly
            740                 745                 


<210> 7952
<211> 383
<212> PRT
<213> Homo sapiens

<400> 7952
Met Asp Pro Lys Arg Ser Gln Lys Glu Ser Val Leu Ile Thr Gly Gly
 1               5                  10                  15      
Ser Gly Tyr Phe Gly Phe Arg Leu Gly Cys Ala Leu Asn Gln Asn Gly
            20                  25                  30          
Val His Val Ile Leu Phe Asp Ile Ser Ser Pro Ala Gln Thr Ile Pro
        35                  40                  45              
Glu Gly Ile Lys Phe Ile Gln Gly Asp Ile Arg His Leu Ser Asp Val
    50                  55                  60                  
Glu Lys Ala Phe Gln Asp Ala Asp Val Thr Cys Val Phe His Ile Ala
65                  70                  75                  80  
Ser Tyr Gly Met Ser Gly Arg Glu Gln Leu Asn Arg Asn Leu Ile Lys
                85                  90                  95      
Glu Val Asn Val Arg Gly Thr Asp Asn Ile Leu Gln Val Cys Gln Arg
            100                 105                 110         
Arg Arg Val Pro Arg Leu Val Tyr Thr Ser Thr Phe Asn Val Ile Phe
        115                 120                 125             
Gly Gly Gln Val Ile Arg Asn Gly Asp Glu Ser Leu Pro Tyr Leu Pro
    130                 135                 140                 
Leu His Leu His Pro Asp His Tyr Ser Arg Thr Lys Ser Ile Ala Glu
145                 150                 155                 160 
Gln Lys Val Leu Glu Ala Asn Ala Thr Pro Leu Asp Arg Gly Asp Gly
                165                 170                 175     
Val Leu Arg Thr Cys Ala Leu Arg Pro Ala Gly Ile Tyr Gly Pro Gly
            180                 185                 190         
Glu Gln Arg His Leu Pro Arg Ile Val Ser Tyr Ile Glu Lys Gly Leu
        195                 200                 205             
Phe Lys Phe Val Tyr Gly Asp Pro Arg Ser Leu Val Glu Phe Val His
    210                 215                 220                 
Val Asp Asn Leu Val Gln Ala His Ile Leu Ala Ser Glu Ala Leu Arg
225                 230                 235                 240 
Ala Asp Lys Gly His Ile Ala Ser Gly Gln Pro Tyr Phe Ile Ser Asp
                245                 250                 255     
Gly Arg Pro Val Asn Asn Phe Glu Phe Phe Arg Pro Leu Val Glu Gly
            260                 265                 270         
Leu Gly Tyr Thr Phe Pro Ser Thr Arg Leu Pro Leu Thr Leu Val Tyr
        275                 280                 285             
Cys Phe Ala Phe Leu Thr Glu Met Val His Phe Ile Leu Gly Arg Leu
    290                 295                 300                 
Tyr Asn Phe Gln Pro Phe Leu Thr Arg Thr Glu Val Tyr Lys Thr Gly
305                 310                 315                 320 
Val Thr His Tyr Phe Ser Leu Glu Lys Ala Lys Lys Glu Leu Gly Tyr
                325                 330                 335     
Lys Ala Gln Pro Phe Asp Leu Gln Glu Ala Val Glu Trp Phe Lys Ala
            340                 345                 350         
His Gly His Gly Arg Ser Ser Gly Ser Arg Asp Ser Glu Cys Phe Val
        355                 360                 365             
Trp Asp Gly Leu Leu Val Phe Leu Leu Ile Ile Ala Val Leu Met
    370                 375                 380             


<210> 7953
<211> 188
<212> PRT
<213> Homo sapiens

<400> 7953
Met Glu Val His Gly Lys Pro Gln Ala Ser Pro Ser Cys Ser Ser Pro
 1               5                  10                  15      
Thr Arg Asp Ser Ser Gly Val Pro Val Ser Lys Glu Leu Leu Thr Ala
            20                  25                  30          
Gly Ser Asp Gly Arg Gly Gly Ile Trp Asp Arg Leu Leu Ile Asn Ser
        35                  40                  45              
Gln Pro Lys Ser Arg Lys Thr Ser Thr Leu Gln Thr Val Arg Ile Glu
    50                  55                  60                  
Arg Ser Pro Leu Leu Asp Gln Val Gln Thr Phe Leu Pro Gln Met Ala
65                  70                  75                  80  
Arg Ala Asn Glu Lys Leu Arg Lys Glu Met Ala Ala Ala Pro Pro Gly
                85                  90                  95      
Arg Phe Asn Ile Glu Asn Ile Asp Gly Pro His Ser Lys Val Ile Gln
            100                 105                 110         
Met Asp Val Ala Leu Phe Glu Met Asn Gln Ser Asp Ser Lys Glu Val
        115                 120                 125             
Asp Ser Ser Glu Glu Ser Ser Gln Asp Ser Ser Glu Asn Ser Ser Glu
    130                 135                 140                 
Ser Glu Asp Glu Asp Asp Ser Ile Pro Ser Glu Val Thr Ile Asp Asn
145                 150                 155                 160 
Ile Lys Leu Pro Asn Ser Glu Gly Gly Lys Gly Lys Ile Glu Val Leu
                165                 170                 175     
Asp Ser Pro Ala Ser Lys Lys Lys Glu Ile Val Lys
            180                 185             


<210> 7954
<211> 994
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 95, 101, 150, 713, 746, 859
<223> Xaa = Any Amino Acid

<400> 7954
Met Ala Ser His Ser Ser Ile Ala Pro Ser Gly Ser Ser Ser Ser Ser
 1               5                  10                  15      
Ser Pro Thr Asp Thr Ser Val Ile Thr Thr Ser Leu Pro Gln Leu Gly
            20                  25                  30          
Asp Leu Thr Thr Leu Gly Asn Phe Ser Val Ile Asn Ser Asn Val Ile
        35                  40                  45              
Ile Glu Asn Leu Gln Ser Thr Lys Val Val Val Ser Gln Phe Ser Gln
    50                  55                  60                  
Glu Val Arg Cys Arg Gly Ala Ser Trp Gly Lys Leu Ala Ile Pro Ala
65                  70                  75                  80  
Leu Met Glu Gln Leu Leu Gly Met Gln Gln Gln Gln Val His Xaa Leu
                85                  90                  95      
Gln Leu Ile Glu Xaa Ile Cys His Gln Ile Leu Leu Leu Ala Ser Gln
            100                 105                 110         
Asn Ala Asp Leu Pro Thr Ser Ser His Pro Ser Gln Gly Thr Leu Gln
        115                 120                 125             
Thr Ser Ala Asn Pro Leu Ser Met Leu Asn Ser His Leu Ser Gln Gln
    130                 135                 140                 
Leu Ala Ala Ala Ala Xaa Leu Ser Gln Ser Leu Ala Ser Gln Ser Ala
145                 150                 155                 160 
Ser Ile Ser Gly Val Lys Gln Leu Pro Pro Ile Gln Leu Leu Gln Ser
                165                 170                 175     
Ser Ser Gly Asn Thr Ile Ile Pro Ser Asn Ser Gly Phe Ser Pro Asn
            180                 185                 190         
Met Asn Ile Leu Val Val Ser Val Thr Thr Pro Ser Ser Glu Lys Val
        195                 200                 205             
Ala Ser Arg Ala Ala Ala Ser His Val Ser Asn Pro Ala Val Ser Ser
    210                 215                 220                 
Ser Ser Ser Pro Ala Phe Ala Ile Ser Ser Leu Leu Ser Pro Ala Ser
225                 230                 235                 240 
Asp Pro Leu Leu His Gln Leu Ala Pro Ala Asn Ser Val Phe Pro Ser
                245                 250                 255     
Pro Leu Pro Asn Ile Gly Thr Thr Ala Gly Asp Leu Asp Ser Leu Ser
            260                 265                 270         
Ala Leu Ala Gln Gln Arg Lys Ser Lys Pro Pro Asn Val Thr Ala Phe
        275                 280                 285             
Glu Val Lys Asn Thr Ser Asn Glu Ala Phe Phe Lys Arg Lys Cys Arg
    290                 295                 300                 
Phe Cys Thr Lys Val Phe Glu Ser Asp Ser Ala Leu Gln Ile His Leu
305                 310                 315                 320 
His Ser His Thr Gly Lys Arg Ala Phe Lys Tyr Asn Ile Cys Gly Asn
                325                 330                 335     
Gly Phe Ser Thr Lys Lys Asn Leu Lys Val His Phe Gln Cys His Lys
            340                 345                 350         
Glu Lys Tyr Thr His Thr Gln Met Asn Pro Tyr Pro Val Pro Glu His
        355                 360                 365             
Leu Asp Asn Ile Pro Met Ser Thr Gly Ile Pro Tyr Gly Met Ser Ile
    370                 375                 380                 
Thr Pro Glu Lys Pro Val Thr Ser Trp Leu Asp Thr Lys Pro Val Leu
385                 390                 395                 400 
Ala Thr Leu Thr Thr Ser Val Cys Leu Pro Leu Leu Pro Thr Leu Pro
                405                 410                 415     
Ser Leu Ile Leu Phe Ile Lys Thr Glu Glu Pro Ala Pro Phe Pro Ile
            420                 425                 430         
Ser His Ser Ala Thr Ser Pro Thr Gly Leu Val Lys Ser Asp Ser Arg
        435                 440                 445             
Ala Ala Glu Leu Ala Thr Arg Asn Leu Gly Gly Leu Pro Glu Glu Ala
    450                 455                 460                 
Glu Gly Ser Thr Leu Pro Pro Ser Ser Gly Lys Ser Lys Glu Ser Gly
465                 470                 475                 480 
Val Val Thr Asn Ser Val Leu Thr Ala Asn Ser Ser Ala Leu Ser Ser
                485                 490                 495     
Pro Ala Ala Asp Trp Gly Pro Leu Gly Lys His Tyr His Leu His Gln
            500                 505                 510         
Pro Phe Val Ala Ser His Val Gln Ala Val Gln Gly Gln Val Ser Phe
        515                 520                 525             
Trp Gly Ala Leu Gly Leu Ser Pro Gly Ile Arg Asp Ile Gln Ala Ser
    530                 535                 540                 
Ala Thr Glu Arg Asn Leu Lys Thr His Tyr Ser Val His His Ala Val
545                 550                 555                 560 
Pro Leu Leu Arg Ala Gln His Ser Cys Pro Ile Cys Trp Lys Leu Thr
                565                 570                 575     
Asp Asp Ala Val Ile Pro Gln Gln His Thr Arg Met His Met Gly Gly
            580                 585                 590         
Gln Val Ser Asn Thr Pro Val Pro Ser Ser Tyr Ser Glu Ser Met Glu
        595                 600                 605             
Ser Asp Ile Gly Ser Phe Tyr Gly Lys Asn Phe Asp Asp Leu Asp Asn
    610                 615                 620                 
Phe Ser Ser Glu Lys Met Glu Asp Cys Pro Glu Gly Arg Phe Pro Asp
625                 630                 635                 640 
Met Pro Lys Ser Ala Asp Asp Ser Gln Asp Ser Leu Ser Ser Ser Pro
                645                 650                 655     
Leu Pro Leu Glu Met Ser Ser Ile Thr Ala Leu Glu Asn Gln Met Lys
            660                 665                 670         
Met Met Asn Val Gly Leu Val Glu Gln Leu Arg Ala Ser Leu Lys Ser
        675                 680                 685             
Val Glu Asn Gly Ser Phe Glu Asp Asp Val Leu Ile Asn Asp Ser Ser
    690                 695                 700                 
Ser Val Gly Asp Asp Met Glu Ser Xaa Ser Ala Gly Ser Pro Ala Ile
705                 710                 715                 720 
Ser Glu Ser Thr Ser Ser Met Gln Ala Leu Ser Pro Ser Asn Ser Thr
                725                 730                 735     
Gln Glu Phe His Lys Ser Pro Arg Glu Xaa Glu Lys Pro Gln Arg Val
            740                 745                 750         
Val Pro Ser Glu Phe Ala Asn Gly Leu Ser Phe Ile Pro Val Asn Gly
        755                 760                 765             
Gly Ala Leu Asp Leu Thr Ser Ser His Ile Gln Lys Ile Ile Arg Glu
    770                 775                 780                 
Asp Ser Leu Gly Thr Leu Phe Pro Phe Arg Val Gln Leu Leu Leu Leu
785                 790                 795                 800 
Ala Leu Pro Arg Thr Pro Lys Gln His Tyr Cys Asn Thr Cys Gly Lys
                805                 810                 815     
Thr Ser Pro Ser Leu Ser Ala Trp Gln Thr His Ile Gly Glu Lys Leu
            820                 825                 830         
Phe Ala Cys Thr Ile Cys Gly Arg Ala Phe Thr Thr Lys Val His Thr
        835                 840                 845             
Gly Thr His Met Trp Asn Ser Thr Pro Val Xaa Gln Gly Arg Gln Leu
    850                 855                 860                 
Ser Gly Asp Gly Pro Met Thr Phe Leu Gly Gly Asn Pro Ile Lys Phe
865                 870                 875                 880 
Pro Glu Met Phe His Lys Asp Leu Val Ala Arg Ser Gly Ser Gly Asp
                885                 890                 895     
Pro Ser Ser Phe Trp Asn Gln Asn Ala Ala Arg His Ser Asn Gly Leu
            900                 905                 910         
Ala Met Lys Gly Asn Gly Thr Ser Val Ile Gln Asn Gly Gly Ile His
        915                 920                 925             
Pro Ile Pro Gly Ser Leu Asp Thr Gly Asn Ser Ser Pro Gly Gly His
    930                 935                 940                 
Asp Glu Leu Asp Glu Asp Gly Glu Leu Tyr Arg Thr Met Pro Ile Ile
945                 950                 955                 960 
Glu Gln Leu Gln Cys Pro Gln His Thr Trp Lys Ala Ile Cys His Leu
                965                 970                 975     
Cys His Leu Asp Asp Ser Pro Gly Val Leu Lys Ser Thr Phe Met Ile
            980                 985                 990         
Ile Leu
        


<210> 7955
<211> 582
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 211, 410, 480
<223> Xaa = Any Amino Acid

<400> 7955
Met Asn Pro Thr Asn Thr Pro Asn Val Phe Asp Ala Lys Cys Leu Ile
 1               5                  10                  15      
Gly Cys Arg Phe Asp Asp Ala Val Val Gln Ser Asp Met Lys His Trp
            20                  25                  30          
Pro Phe Met Val Val Asn Asp Ala Val Arg Leu Lys Val Gln Val Glu
        35                  40                  45              
Tyr Lys Gly Glu Thr Lys Ser Phe Tyr Pro Glu Glu Val Pro Ser Met
    50                  55                  60                  
Val Leu Thr Lys Met Lys Glu Ile Ala Glu Ala Asp Leu Gly Lys Ile
65                  70                  75                  80  
Val Thr Asn Ala Val Val Thr Val Ser Ala Tyr Phe Asn Asp Cys Gln
                85                  90                  95      
Cys Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn Val Leu
            100                 105                 110         
Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp
        115                 120                 125             
Lys Lys Val Gly Ala Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Asp
    130                 135                 140                 
Asp Thr Phe Asn Val Ser Ile Leu Thr Thr Glu Asp Gly Ile Phe Glu
145                 150                 155                 160 
Val Lys Ser Arg Ala Gly Asp Thr His Leu Cys Gly Glu Asp Phe Asp
                165                 170                 175     
Tyr Arg Met Val Asn His Phe Thr Ala Glu Phe Lys His Lys His Lys
            180                 185                 190         
Lys Gly Ile Asn Glu Asn Lys Arg Val Leu Arg Cys Leu His Thr Ala
        195                 200                 205             
Cys Glu Xaa Ala Lys Cys Thr Leu Ser Ser Ser Thr Leu Ala Ser Ile
    210                 215                 220                 
Glu Ile Asp Ser Leu Tyr Glu Gly Ile Asn Phe Tyr Thr Ser Ile Thr
225                 230                 235                 240 
His Ala Arg Phe Glu Glu Lys Asn Ala Asp Leu Phe His Gly Thr Leu
                245                 250                 255     
Asp Pro Ile Glu Lys Ala Leu Arg Asp Ala Lys Leu Glu Lys Ser Gln
            260                 265                 270         
Ile His Asp Ile Val Leu Ile Gly Gly Ser Thr His Thr Leu Ile Gln
        275                 280                 285             
Lys Leu Leu Gln Asp Leu Phe Asn Arg Lys Glu Leu Asn Lys Ser Ile
    290                 295                 300                 
Asn Pro Asp Glu Ala Ile Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile
305                 310                 315                 320 
Leu Ser Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp
                325                 330                 335     
Val Thr Leu Leu Ser Leu Arg Ile Glu Ala Ala Asp Gly Val Met Thr
            340                 345                 350         
Val Leu Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Asn
        355                 360                 365             
Phe Thr Thr Tyr Ser Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr
    370                 375                 380                 
Glu Gly Glu Cys Ala Met Thr Lys Asp Asn Asn Trp Phe Gly Lys Phe
385                 390                 395                 400 
Glu Leu Thr Gly Ile Pro Pro Ala Pro Xaa Gly Val Pro Gln Val Glu
                405                 410                 415     
Val Thr Phe Asp Ile Asp Ala Asn Val Ile Leu Asn Val Ser Ala Val
            420                 425                 430         
Asp Lys Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys
        435                 440                 445             
Arg Arg Leu Ser Lys Glu Asp Ile Glu Arg Met Ala Gln Glu Ala Glu
    450                 455                 460                 
Lys Tyr Lys Ala Glu Asp Glu Lys Gln Arg Gly Lys Val Ser Ser Xaa
465                 470                 475                 480 
Asn Ser Leu Glu Ser Tyr Ala Phe Asn Met Lys Ser Thr Val Glu Asp
                485                 490                 495     
Glu Lys Leu Gln Gly Lys Ile Asn Asp Asp Asp Lys Gln Lys Ile Leu
            500                 505                 510         
Asp Lys Cys Asn Glu Ile Ile Asn Trp Leu Asp Lys Asn Gln Ala Ala
        515                 520                 525             
Glu Lys Glu Glu Phe Glu His Gln Gln Lys Ala Gly Glu Ser Leu Gln
    530                 535                 540                 
Pro His Gln His Gln Ala Val Pro Glu Cys Arg Arg His Ala Arg Arg
545                 550                 555                 560 
Asn Ala Trp Gly Ile Pro Trp Trp Trp Ser Ser Ser Leu Trp Trp Cys
                565                 570                 575     
Phe Leu Arg Ala Tyr Tyr
            580         


<210> 7956
<211> 824
<212> PRT
<213> Homo sapiens

<400> 7956
Met Gly Ser Glu Lys Gly Lys Ala Gly Thr Ala Thr Leu Ala Met Ser
 1               5                  10                  15      
Glu Lys Val Arg Thr Arg Leu Glu Glu Leu Asp Asp Phe Glu Glu Gly
            20                  25                  30          
Ser Gln Lys Glu Leu Leu Asn Leu Thr Gln Gln Asp Tyr Val Asn Arg
        35                  40                  45              
Ile Glu Glu Leu Asn Gln Ser Leu Lys Asp Ala Trp Ala Ser Asp Gln
    50                  55                  60                  
Lys Val Lys Ala Leu Lys Ile Val Ile Gln Cys Ser Lys Leu Leu Ser
65                  70                  75                  80  
Asp Thr Ser Val Ile Gln Phe Tyr Pro Ser Lys Phe Val Leu Ile Thr
                85                  90                  95      
Asp Ile Leu Asp Thr Phe Gly Lys Leu Val Tyr Glu Arg Ile Phe Ser
            100                 105                 110         
Met Cys Val Asp Ser Arg Ser Val Leu Pro Asp His Phe Ser Pro Glu
        115                 120                 125             
Asn Ala Asn Asp Thr Ala Lys Glu Thr Cys Leu Asn Trp Phe Phe Lys
    130                 135                 140                 
Ile Ala Ser Ile Arg Glu Leu Ile Pro Arg Phe Tyr Val Glu Ala Ser
145                 150                 155                 160 
Ile Leu Lys Cys Asn Lys Phe Leu Ser Lys Thr Gly Ile Ser Glu Cys
                165                 170                 175     
Leu Pro Arg Leu Thr Cys Met Ile Arg Gly Ile Gly Asp Pro Leu Val
            180                 185                 190         
Ser Val Tyr Ala Arg Ala Tyr Leu Cys Arg Val Gly Met Glu Val Ala
        195                 200                 205             
Pro His Leu Lys Glu Thr Leu Asn Lys Asn Phe Phe Asp Phe Leu Leu
    210                 215                 220                 
Thr Phe Lys Gln Ile His Gly Asp Thr Val Gln Asn Gln Leu Val Val
225                 230                 235                 240 
Gln Gly Val Glu Leu Pro Ser Tyr Leu Pro Leu Tyr Pro Pro Ala Met
                245                 250                 255     
Asp Trp Ile Phe Gln Cys Ile Ser Tyr His Ala Pro Glu Ala Leu Leu
            260                 265                 270         
Thr Glu Met Met Glu Arg Cys Lys Lys Leu Gly Asn Asn Ala Leu Leu
        275                 280                 285             
Leu Asn Ser Val Met Ser Ala Phe Arg Ala Glu Phe Ile Ala Thr Arg
    290                 295                 300                 
Ser Met Asp Phe Ile Gly Met Ile Lys Glu Cys Asp Glu Ser Gly Phe
305                 310                 315                 320 
Pro Lys His Leu Leu Phe Arg Ser Leu Gly Leu Asn Leu Ala Leu Ala
                325                 330                 335     
Asp Pro Pro Glu Ser Asp Arg Leu Gln Ile Leu Asn Glu Ala Trp Lys
            340                 345                 350         
Val Ile Thr Lys Leu Lys Asn Pro Gln Asp Tyr Ile Asn Cys Ala Glu
        355                 360                 365             
Val Trp Val Glu Tyr Thr Cys Lys His Phe Thr Lys Arg Glu Val Asn
    370                 375                 380                 
Thr Val Leu Ala Asp Val Ile Lys His Met Thr Pro Asp Arg Ala Phe
385                 390                 395                 400 
Glu Asp Ser Tyr Pro Gln Leu Gln Leu Ile Ile Lys Lys Val Ile Ala
                405                 410                 415     
His Phe His Asp Phe Ser Val Leu Phe Ser Val Glu Lys Phe Leu Pro
            420                 425                 430         
Phe Leu Asp Met Phe Gln Lys Glu Ser Val Arg Val Glu Val Cys Lys
        435                 440                 445             
Cys Ile Met Asp Ala Phe Ile Lys His Gln Gln Glu Pro Thr Lys Asp
    450                 455                 460                 
Pro Val Ile Leu Asn Ala Leu Leu His Val Cys Lys Thr Met His Asp
465                 470                 475                 480 
Ser Val Asn Ala Leu Thr Leu Glu Asp Glu Lys Arg Met Leu Ser Tyr
                485                 490                 495     
Leu Ile Asn Gly Phe Ile Lys Met Val Ser Phe Gly Arg Asp Phe Glu
            500                 505                 510         
Gln Gln Leu Ser Phe Tyr Val Glu Ser Arg Ser Met Phe Cys Asn Leu
        515                 520                 525             
Glu Pro Val Leu Val Gln Leu Ile His Ser Val Asn Arg Leu Ala Met
    530                 535                 540                 
Glu Thr Arg Lys Val Met Lys Gly Asn His Ser Arg Lys Thr Ala Ala
545                 550                 555                 560 
Phe Val Arg Ala Cys Val Ala Tyr Cys Phe Ile Thr Ile Pro Ser Leu
                565                 570                 575     
Ala Gly Ile Phe Thr Arg Leu Asn Leu Tyr Leu His Ser Gly Gln Val
            580                 585                 590         
Ala Leu Ala Asn Gln Cys Leu Ser Gln Ala Asp Ala Phe Phe Lys Ala
        595                 600                 605             
Ala Ile Ser Leu Val Pro Glu Val Pro Lys Met Ile Asn Ile Asp Gly
    610                 615                 620                 
Lys Met Arg Pro Ser Glu Ser Phe Leu Leu Glu Phe Leu Cys Asn Phe
625                 630                 635                 640 
Phe Ser Thr Leu Leu Ile Val Pro Asp His Pro Glu His Gly Val Leu
                645                 650                 655     
Phe Leu Val Arg Glu Leu Leu Asn Val Ile Gln Asp Tyr Thr Trp Glu
            660                 665                 670         
Asp Asn Ser Asp Glu Lys Ile Arg Ile Tyr Thr Cys Val Leu His Leu
        675                 680                 685             
Leu Ser Ala Met Ser Gln Glu Thr Tyr Leu Tyr His Ile Asp Lys Val
    690                 695                 700                 
Asp Ser Asn Asp Ser Leu Tyr Gly Gly Asp Ser Lys Phe Leu Ala Glu
705                 710                 715                 720 
Asn Asn Lys Leu Cys Glu Thr Val Met Ala Gln Ile Leu Glu His Leu
                725                 730                 735     
Lys Thr Leu Ala Lys Asp Glu Ala Leu Lys Arg Gln Ser Ser Leu Gly
            740                 745                 750         
Leu Ser Phe Phe Asn Ser Ile Leu Ala His Gly Asp Leu Arg Asn Asn
        755                 760                 765             
Lys Leu Asn Gln Leu Ser Val Asn Leu Trp His Leu Ala Gln Arg His
    770                 775                 780                 
Gly Cys Ala Asp Thr Arg Thr Met Val Lys Thr Leu Glu Tyr Ile Lys
785                 790                 795                 800 
Lys Gln Ser Lys Gln Pro Asp Met Thr His Leu Thr Glu Leu Ala Leu
                805                 810                 815     
Arg Leu Pro Leu Gln Thr Arg Thr
            820                 


<210> 7957
<211> 813
<212> PRT
<213> Homo sapiens

<400> 7957
Met Pro Pro Leu Gly Val Leu Val His Glu Lys Ser His Leu Cys Asp
 1               5                  10                  15      
Val Asn Ser Phe Cys Leu Gly Lys Ala Gly Thr Ala Thr Leu Ala Met
            20                  25                  30          
Ser Glu Lys Val Arg Thr Arg Leu Glu Glu Leu Asp Asp Phe Glu Glu
        35                  40                  45              
Gly Ser Gln Lys Glu Leu Leu Asn Leu Thr Gln Gln Asp Tyr Val Asn
    50                  55                  60                  
Arg Ile Glu Glu Leu Asn Gln Ser Leu Lys Asp Ala Trp Ala Ser Asp
65                  70                  75                  80  
Gln Lys Val Lys Ala Leu Lys Ile Val Ile Gln Glu Glu Leu Val Tyr
                85                  90                  95      
Glu Arg Ile Phe Ser Met Cys Val Asp Ser Arg Ser Val Leu Pro Asp
            100                 105                 110         
His Phe Ser Pro Glu Asn Ala Asn Asp Thr Ala Lys Glu Thr Cys Leu
        115                 120                 125             
Asn Trp Phe Phe Lys Ile Ala Ser Ile Arg Glu Leu Ile Pro Arg Phe
    130                 135                 140                 
Tyr Val Glu Ala Ser Ile Leu Lys Cys Asn Lys Phe Leu Ser Lys Thr
145                 150                 155                 160 
Gly Ile Ser Glu Cys Leu Pro Arg Leu Thr Cys Met Ile Arg Gly Ile
                165                 170                 175     
Gly Asp Pro Leu Val Ser Val Tyr Ala Arg Ala Tyr Leu Gly Arg Val
            180                 185                 190         
Gly Met Glu Val Ala Pro His Leu Lys Glu Thr Leu Asn Lys Asn Phe
        195                 200                 205             
Phe Asp Phe Leu Leu Thr Phe Lys Gln Ile His Gly Asp Thr Val Gln
    210                 215                 220                 
Asn Gln Leu Val Val Gln Gly Val Glu Leu Pro Ser Tyr Leu Pro Leu
225                 230                 235                 240 
Tyr Pro Pro Ala Met Asp Trp Ile Phe Gln Cys Ile Ser Tyr His Ala
                245                 250                 255     
Pro Glu Ala Leu Leu Thr Glu Met Met Glu Arg Cys Lys Lys Leu Gly
            260                 265                 270         
Asn Asn Ala Leu Leu Leu Asn Ser Val Met Ser Ala Phe Arg Ala Glu
        275                 280                 285             
Phe Ile Ala Thr Arg Ser Met Asp Phe Ile Gly Met Ile Lys Glu Cys
    290                 295                 300                 
Asp Glu Ser Gly Phe Pro Lys His Leu Leu Phe Arg Ser Leu Gly Leu
305                 310                 315                 320 
Asn Leu Ala Leu Ala Asp Pro Pro Glu Ser Asp Arg Leu Gln Ile Leu
                325                 330                 335     
Asn Glu Ala Trp Lys Val Ile Thr Lys Leu Lys Asn Pro Gln Asp Tyr
            340                 345                 350         
Ile Asn Cys Ala Glu Val Trp Val Glu Tyr Thr Cys Lys His Phe Thr
        355                 360                 365             
Lys Arg Glu Val Asn Thr Val Leu Ala Asp Val Ile Lys His Met Thr
    370                 375                 380                 
Pro Asp Arg Ala Phe Glu Asp Ser Tyr Pro Gln Leu Gln Leu Ile Ile
385                 390                 395                 400 
Lys Lys Val Ile Ala His Phe His Asp Phe Ser Val Leu Phe Ser Val
                405                 410                 415     
Glu Lys Phe Leu Pro Phe Leu Asp Met Phe Gln Lys Glu Ser Val Arg
            420                 425                 430         
Val Glu Val Cys Lys Cys Ile Met Asp Ala Phe Ile Lys His Gln Gln
        435                 440                 445             
Glu Pro Thr Lys Asp Pro Val Ile Leu Asn Ala Leu Leu His Val Cys
    450                 455                 460                 
Lys Thr Met His Asp Ser Val Asn Ala Leu Thr Leu Glu Asp Glu Lys
465                 470                 475                 480 
Arg Met Leu Ser Tyr Leu Ile Asn Gly Phe Ile Lys Met Val Ser Phe
                485                 490                 495     
Gly Arg Asp Phe Glu Gln Gln Leu Ser Phe Tyr Val Glu Ser Arg Ser
            500                 505                 510         
Met Phe Cys Asn Leu Glu Pro Val Leu Val Gln Leu Ile His Ser Val
        515                 520                 525             
Asn Arg Leu Ala Met Glu Thr Arg Lys Val Met Lys Gly Asn His Ser
    530                 535                 540                 
Arg Lys Thr Ala Ala Phe Val Arg Ala Cys Val Ala Tyr Cys Phe Ile
545                 550                 555                 560 
Thr Ile Pro Ser Leu Ala Gly Ile Phe Thr Arg Leu Asn Leu Tyr Leu
                565                 570                 575     
His Ser Gly Gln Val Ala Leu Ala Asn Gln Cys Leu Ser Gln Ala Asp
            580                 585                 590         
Ala Phe Phe Lys Ala Ala Ile Ser Leu Val Pro Glu Val Pro Lys Met
        595                 600                 605             
Ile Asn Ile Asp Gly Lys Met Arg Pro Ser Glu Ser Phe Leu Leu Glu
    610                 615                 620                 
Phe Leu Cys Asn Phe Phe Ser Thr Leu Leu Ile Val Pro Asp His Pro
625                 630                 635                 640 
Glu His Gly Val Leu Phe Leu Val Arg Glu Leu Leu Asn Val Ile Gln
                645                 650                 655     
Asp Tyr Thr Trp Glu Asp Asn Ser Asp Glu Lys Ile Arg Ile Tyr Thr
            660                 665                 670         
Cys Val Leu His Leu Leu Ser Ala Met Ser Gln Glu Thr Tyr Leu Tyr
        675                 680                 685             
His Ile Asp Lys Val Asp Ser Asn Asp Ser Leu Tyr Gly Gly Asp Ser
    690                 695                 700                 
Lys Phe Leu Ala Glu Asn Asn Lys Leu Cys Glu Thr Val Met Ala Gln
705                 710                 715                 720 
Ile Leu Glu His Leu Lys Thr Leu Ala Lys Asp Glu Ala Leu Lys Arg
                725                 730                 735     
Gln Ser Ser Leu Gly Leu Ser Phe Phe Asn Ser Ile Leu Ala His Gly
            740                 745                 750         
Asp Leu Arg Asn Asn Lys Leu Asn Gln Leu Ser Val Asn Leu Trp His
        755                 760                 765             
Leu Ala Gln Arg His Gly Cys Ala Asp Thr Arg Thr Met Val Lys Thr
    770                 775                 780                 
Leu Glu Tyr Ile Lys Lys Gln Ser Lys Gln Pro Asp Met Thr His Leu
785                 790                 795                 800 
Thr Glu Leu Ala Leu Arg Leu Pro Leu Gln Thr Arg Thr
                805                 810             


<210> 7958
<211> 963
<212> PRT
<213> Homo sapiens

<400> 7958
Met Ala Val Phe Pro Trp His Ser Arg Asn Arg Asn Tyr Lys Ala Glu
 1               5                  10                  15      
Phe Ala Ser Cys Arg Leu Glu Ala Val Pro Leu Glu Phe Gly Asp Tyr
            20                  25                  30          
His Pro Leu Lys Pro Ile Thr Val Thr Glu Ser Lys Thr Lys Lys Val
        35                  40                  45              
Asn Arg Lys Gly Ser Thr Ser Ser Thr Ser Ser Ser Ser Ser Ser Ser
    50                  55                  60                  
Val Val Asp Pro Leu Ser Ser Val Leu Asp Gly Thr Asp Pro Leu Ser
65                  70                  75                  80  
Met Phe Ala Ala Thr Ala Asp Pro Ala Ala Leu Ala Ala Ala Met Asp
                85                  90                  95      
Ser Ser Arg Arg Lys Arg Asp Arg Asp Asp Asn Ser Val Val Gly Ser
            100                 105                 110         
Asp Phe Glu Pro Trp Thr Asn Lys Arg Gly Glu Ile Leu Ala Arg Tyr
        115                 120                 125             
Thr Thr Thr Glu Lys Leu Ser Ile Asn Leu Phe Met Gly Ser Glu Lys
    130                 135                 140                 
Gly Lys Ala Gly Thr Ala Thr Leu Ala Met Ser Glu Lys Val Arg Thr
145                 150                 155                 160 
Arg Leu Glu Glu Leu Asp Asp Phe Glu Glu Gly Ser Gln Lys Glu Leu
                165                 170                 175     
Leu Asn Leu Thr Gln Gln Asp Tyr Val Asn Arg Ile Glu Glu Leu Asn
            180                 185                 190         
Gln Ser Leu Lys Asp Ala Trp Ala Ser Asp Gln Lys Val Lys Ala Leu
        195                 200                 205             
Lys Ile Val Ile Gln Cys Ser Lys Leu Leu Ser Asp Thr Ser Val Ile
    210                 215                 220                 
Gln Phe Tyr Pro Ser Lys Phe Val Leu Ile Thr Asp Ile Leu Asp Thr
225                 230                 235                 240 
Phe Gly Lys Leu Val Tyr Glu Arg Ile Phe Ser Met Cys Val Asp Ser
                245                 250                 255     
Arg Ser Val Leu Pro Asp His Phe Ser Pro Glu Asn Ala Asn Asp Thr
            260                 265                 270         
Ala Lys Glu Thr Cys Leu Asn Trp Phe Phe Lys Ile Ala Ser Ile Arg
        275                 280                 285             
Glu Leu Ile Pro Arg Phe Tyr Val Glu Ala Ser Ile Leu Lys Cys Asn
    290                 295                 300                 
Lys Phe Leu Ser Lys Thr Gly Ile Ser Glu Cys Leu Pro Arg Leu Thr
305                 310                 315                 320 
Cys Met Ile Arg Gly Ile Gly Asp Pro Leu Val Ser Val Tyr Ala Arg
                325                 330                 335     
Ala Tyr Leu Cys Arg Val Gly Met Glu Val Ala Pro His Leu Lys Glu
            340                 345                 350         
Thr Leu Asn Lys Asn Phe Phe Asp Phe Leu Leu Thr Phe Lys Gln Ile
        355                 360                 365             
His Gly Asp Thr Val Gln Asn Gln Leu Val Val Gln Gly Val Glu Leu
    370                 375                 380                 
Pro Ser Tyr Leu Pro Leu Tyr Pro Pro Ala Met Asp Trp Ile Phe Gln
385                 390                 395                 400 
Cys Ile Ser Tyr His Ala Pro Glu Ala Leu Leu Thr Glu Met Met Glu
                405                 410                 415     
Arg Cys Lys Lys Leu Gly Asn Asn Ala Leu Leu Leu Asn Ser Val Met
            420                 425                 430         
Ser Ala Phe Arg Ala Glu Phe Ile Ala Thr Arg Ser Met Asp Phe Ile
        435                 440                 445             
Gly Met Ile Lys Glu Cys Asp Glu Ser Gly Phe Pro Lys His Leu Leu
    450                 455                 460                 
Phe Arg Ser Leu Gly Leu Asn Leu Ala Leu Ala Asp Pro Pro Glu Ser
465                 470                 475                 480 
Asp Arg Leu Gln Ile Leu Asn Glu Ala Trp Lys Val Ile Thr Lys Leu
                485                 490                 495     
Lys Asn Pro Gln Asp Tyr Ile Asn Cys Ala Glu Val Trp Val Glu Tyr
            500                 505                 510         
Thr Cys Lys His Phe Thr Lys Arg Glu Val Asn Thr Val Leu Ala Asp
        515                 520                 525             
Val Ile Lys His Met Thr Pro Asp Arg Ala Phe Glu Asp Ser Tyr Pro
    530                 535                 540                 
Gln Leu Gln Leu Ile Ile Lys Lys Val Ile Ala His Phe His Asp Phe
545                 550                 555                 560 
Ser Val Leu Phe Ser Val Glu Lys Phe Leu Pro Phe Leu Asp Met Phe
                565                 570                 575     
Gln Lys Glu Ser Val Arg Val Glu Val Cys Lys Cys Ile Met Asp Ala
            580                 585                 590         
Phe Ile Lys His Gln Gln Glu Pro Thr Lys Asp Pro Val Ile Leu Asn
        595                 600                 605             
Ala Leu Leu His Val Cys Lys Thr Met His Asp Ser Val Asn Ala Leu
    610                 615                 620                 
Thr Leu Glu Asp Glu Lys Arg Met Leu Ser Tyr Leu Ile Asn Gly Phe
625                 630                 635                 640 
Ile Lys Met Val Ser Phe Gly Arg Asp Phe Glu Gln Gln Leu Ser Phe
                645                 650                 655     
Tyr Val Glu Ser Arg Ser Met Phe Cys Asn Leu Glu Pro Val Leu Val
            660                 665                 670         
Gln Leu Ile His Ser Val Asn Arg Leu Ala Met Glu Thr Arg Lys Val
        675                 680                 685             
Met Lys Gly Asn His Ser Arg Lys Thr Ala Ala Phe Val Arg Ala Cys
    690                 695                 700                 
Val Ala Tyr Cys Phe Ile Thr Ile Pro Ser Leu Ala Gly Ile Phe Thr
705                 710                 715                 720 
Arg Leu Asn Leu Tyr Leu His Ser Gly Gln Val Ala Leu Ala Asn Gln
                725                 730                 735     
Cys Leu Ser Gln Ala Asp Ala Phe Phe Lys Ala Ala Ile Ser Leu Val
            740                 745                 750         
Pro Glu Val Pro Lys Met Ile Asn Ile Asp Gly Lys Met Arg Pro Ser
        755                 760                 765             
Glu Ser Phe Leu Leu Glu Phe Leu Cys Asn Phe Phe Ser Thr Leu Leu
    770                 775                 780                 
Ile Val Pro Asp His Pro Glu His Gly Val Leu Phe Leu Val Arg Glu
785                 790                 795                 800 
Leu Leu Asn Val Ile Gln Asp Tyr Thr Trp Glu Asp Asn Ser Asp Glu
                805                 810                 815     
Lys Ile Arg Ile Tyr Thr Cys Val Leu His Leu Leu Ser Ala Met Ser
            820                 825                 830         
Gln Glu Thr Tyr Leu Tyr His Ile Asp Lys Val Asp Ser Asn Asp Ser
        835                 840                 845             
Leu Tyr Gly Gly Asp Ser Lys Phe Leu Ala Glu Asn Asn Lys Leu Cys
    850                 855                 860                 
Glu Thr Val Met Ala Gln Ile Leu Glu His Leu Lys Thr Leu Ala Lys
865                 870                 875                 880 
Asp Glu Ala Leu Lys Arg Gln Ser Ser Leu Gly Leu Ser Phe Phe Asn
                885                 890                 895     
Ser Ile Leu Ala His Gly Asp Leu Arg Asn Asn Lys Leu Asn Gln Leu
            900                 905                 910         
Ser Val Asn Leu Trp His Leu Ala Gln Arg His Gly Cys Ala Asp Thr
        915                 920                 925             
Arg Thr Met Val Lys Thr Leu Glu Tyr Ile Lys Lys Gln Ser Lys Gln
    930                 935                 940                 
Pro Asp Met Thr His Leu Thr Glu Leu Ala Leu Arg Leu Pro Leu Gln
945                 950                 955                 960 
Thr Arg Thr
            


<210> 7959
<211> 668
<212> PRT
<213> Homo sapiens

<400> 7959
Met Ser Asn Val Thr Leu Arg Lys Met Ser Pro Thr Gly Asn Glu Met
 1               5                  10                  15      
Lys Ser Thr Thr Gln Gly Thr Thr Arg Lys Gln Gln Asp Phe His Glu
            20                  25                  30          
Val Asn Lys Arg Arg Thr Phe Leu Gln Asp Asn Ser Trp Ile Lys Lys
        35                  40                  45              
Arg Pro Glu Glu Glu Lys Asp Glu Asn Tyr Gly Arg Val Val Leu Asn
    50                  55                  60                  
Arg His Asn Ser His Asp Ala Leu Asp Arg Lys Val Asn Glu Arg Asp
65                  70                  75                  80  
Val Pro Lys Ala Thr Ile Ser Arg Tyr Ser Ser Asp Asp Thr Leu Asp
                85                  90                  95      
Arg Ile Ser Asp Arg Asn Asp Ala Ala Lys Thr Tyr Lys Ala Asn Thr
            100                 105                 110         
Leu Asp Asn Gln Leu Thr Asn Arg Ser Met Ser Val Phe Arg Ser Leu
        115                 120                 125             
Glu Val Thr Lys Leu Gln Pro Gly Gly Ser Leu Asn Ala Asn Thr Ser
    130                 135                 140                 
Asn Thr Ile Ala Ser Thr Ser Ala Thr Thr Pro Val Lys Lys Lys Arg
145                 150                 155                 160 
Gln Ser Trp Phe Pro Pro Pro Pro Pro Gly Tyr Asn Ala Ser Ser Ser
                165                 170                 175     
Thr Gly Thr Arg Arg Arg Glu Pro Gly Val His Pro Pro Ile Pro Pro
            180                 185                 190         
Lys Pro Ser Ser Pro Val Ser Ser Thr Asn Gln Leu Arg Gln Asp Asn
        195                 200                 205             
Arg Gln Ile His Pro Pro Lys Pro Gly Val Tyr Thr Glu Thr Asn Arg
    210                 215                 220                 
Ser Ala Glu Arg Asn Ile Ser Glu Glu Leu Asp Asn Leu Ile Lys Met
225                 230                 235                 240 
Asn Lys Ser Leu Asn Arg Asn Gln Gly Leu Asp Ser Leu Phe Arg Ala
                245                 250                 255     
Asn Pro Lys Val Glu Glu Arg Glu Lys Arg Ala Lys Ser Leu Glu Ser
            260                 265                 270         
Leu Ile Tyr Met Ser Thr Arg Thr Asp Lys Asp Gly Lys Gly Ile Gln
        275                 280                 285             
Ser Leu Gly Ser Pro Ile Lys Val Asn Gln Arg Thr Asp Lys Asn Glu
    290                 295                 300                 
Lys Gly Arg Gln Asn Leu Glu Ser Val Ala Lys Val Asn Ala Arg Met
305                 310                 315                 320 
Asn Lys Thr Ser Arg Arg Ser Glu Asp Leu Asp Asn Ala Thr Glu Val
                325                 330                 335     
Asn Pro Lys Gly His Glu Asn Thr Thr Gly Lys Lys Asp Leu Asp Gly
            340                 345                 350         
Leu Ile Lys Val Asp Pro Glu Thr Asn Lys Asn Ile Thr Arg Gly Gln
        355                 360                 365             
Ser Leu Asp Asn Leu Ile Lys Val Thr Pro Glu Val Lys Arg Ser Asn
    370                 375                 380                 
Gln Gly Ser Lys Asp Leu Asn Asn Phe Ile Lys Val Tyr Pro Gly Thr
385                 390                 395                 400 
Glu Lys Ser Thr Glu Gly Gly Gln Ser Leu Asp Ser Leu Ile Lys Val
                405                 410                 415     
Thr Pro Glu Arg Asn Arg Thr Asn Gln Gly Asn Gln Asp Leu Glu Asn
            420                 425                 430         
Leu Ile Lys Val Ile Pro Ser Ala Asn Lys Ser Ser Glu Gln Gly Leu
        435                 440                 445             
Asp Glu His Ile Asn Val Ser Pro Lys Ala Val Lys Asn Thr Asp Gly
    450                 455                 460                 
Lys Gln Asp Leu Asp Lys Leu Ile Lys Val Asn Pro Glu Ile Phe Thr
465                 470                 475                 480 
Asn Asn Gln Arg Asn Gln Asp Leu Ala Asn Leu Ile Lys Val Asn Pro
                485                 490                 495     
Ala Val Ile Arg Asn Asn Gln Ser Gln Asp Leu Asp Asn Leu Ile Lys
            500                 505                 510         
Val Lys Pro Ser Ala Leu Arg Asn Thr Asn Arg Asp Gln Asn Leu Glu
        515                 520                 525             
Asn Leu Ile Glu Val Asn Ser His Val Ser Glu Asn Lys Asn Gly Ser
    530                 535                 540                 
Ser Asn Thr Gly Ala Lys Gln Ala Gly Pro Gln Asp Thr Val Val Tyr
545                 550                 555                 560 
Thr Arg Thr Tyr Val Glu Asn Ser Lys Ser Pro Lys Asp Gly Tyr Gln
                565                 570                 575     
Glu Asn Ile Ser Gly Lys Tyr Ile Gln Thr Val Tyr Ser Thr Ser Asp
            580                 585                 590         
Arg Ser Val Ile Glu Arg Asp Met Cys Thr Tyr Cys Arg Lys Pro Leu
        595                 600                 605             
Gly Val Glu Thr Lys Met Ile Leu Asp Glu Leu Gln Ile Cys Cys His
    610                 615                 620                 
Ser Thr Cys Phe Lys Cys Glu Ile Cys Lys Gln Pro Leu Glu Asn Leu
625                 630                 635                 640 
Gln Ala Gly Asp Ser Ile Trp Ile Tyr Arg Gln Thr Ile His Cys Glu
                645                 650                 655     
Pro Cys Tyr Ser Lys Ile Met Ala Lys Trp Ile Pro
            660                 665             


<210> 7960
<211> 688
<212> PRT
<213> Homo sapiens

<400> 7960
Met Ser Asn Val Thr Leu Arg Lys Met Ser Pro Thr Gly Asn Glu Met
 1               5                  10                  15      
Lys Ser Thr Thr Gln Gly Thr Thr Arg Lys Gln Gln Asp Phe His Glu
            20                  25                  30          
Val Asn Lys Arg Arg Thr Phe Leu Gln Asp Asn Ser Trp Ile Lys Lys
        35                  40                  45              
Arg Pro Glu Glu Glu Lys Asp Glu Asn Tyr Gly Arg Val Val Leu Asn
    50                  55                  60                  
Arg His Asn Ser His Asp Ala Leu Asp Arg Lys Val Asn Glu Arg Asp
65                  70                  75                  80  
Val Pro Lys Ala Thr Ile Ser Arg Tyr Ser Ser Asp Asp Thr Leu Asp
                85                  90                  95      
Arg Ile Ser Asp Arg Asn Asp Ala Ala Lys Thr Tyr Lys Ala Asn Thr
            100                 105                 110         
Leu Asp Asn Gln Leu Thr Asn Arg Ser Met Ser Met Phe Arg Ser Leu
        115                 120                 125             
Glu Val Thr Lys Leu Gln Pro Gly Gly Ser Leu Asn Ala Asn Thr Ser
    130                 135                 140                 
Asn Thr Ile Ala Ser Thr Ser Ala Thr Thr Pro Val Lys Lys Lys Arg
145                 150                 155                 160 
Gln Ser Trp Phe Pro Pro Pro Pro Pro Gly Tyr Asn Ala Ser Ser Ser
                165                 170                 175     
Thr Gly Thr Arg Arg Arg Glu Pro Gly Val His Pro Pro Ile Pro Pro
            180                 185                 190         
Lys Pro Ser Ser Pro Val Ser Ser Pro Asn Gln Leu Arg Gln Asp Asn
        195                 200                 205             
Arg Gln Ile His Pro Pro Lys Pro Gly Val Tyr Thr Glu Thr Asn Arg
    210                 215                 220                 
Ser Ala Glu Arg Asn Ile Arg Ser Gln Asp Leu Asp Asn Ile Val Lys
225                 230                 235                 240 
Val Ala Thr Ser Leu Gln Arg Ser Asp Lys Gly Glu Glu Leu Asp Asn
                245                 250                 255     
Leu Ile Lys Met Asn Lys Ser Leu Asn Arg Asn Gln Gly Leu Asp Ser
            260                 265                 270         
Leu Phe Arg Ala Asn Pro Lys Val Glu Glu Arg Glu Lys Arg Ala Lys
        275                 280                 285             
Ser Leu Glu Ser Leu Ile Tyr Met Ser Thr Arg Thr Asp Lys Asp Gly
    290                 295                 300                 
Lys Gly Ile Gln Ser Leu Gly Ser Pro Ile Lys Val Asn Gln Arg Thr
305                 310                 315                 320 
Asp Lys Asn Glu Lys Gly Arg Gln Asn Leu Glu Ser Val Ala Lys Val
                325                 330                 335     
Asn Ala Arg Met Asn Lys Thr Ser Arg Arg Ser Glu Asp Leu Asp Asn
            340                 345                 350         
Ala Thr Glu Val Asn Pro Lys Gly His Glu Asn Thr Thr Gly Lys Lys
        355                 360                 365             
Asp Leu Asp Gly Leu Ile Lys Val Asp Pro Glu Thr Asn Lys Asn Ile
    370                 375                 380                 
Thr Arg Gly Gln Ser Leu Asp Asn Leu Ile Lys Val Thr Pro Glu Val
385                 390                 395                 400 
Lys Arg Ser Asn Gln Gly Ser Lys Asp Leu Asn Asn Phe Ile Lys Val
                405                 410                 415     
Tyr Pro Gly Thr Glu Lys Ser Thr Glu Gly Gly Gln Ser Leu Asp Ser
            420                 425                 430         
Leu Ile Lys Val Thr Pro Glu Arg Asn Arg Thr Asn Gln Gly Asn Gln
        435                 440                 445             
Asp Leu Glu Asn Leu Ile Lys Val Ile Pro Ser Ala Asn Lys Ser Ser
    450                 455                 460                 
Glu Gln Gly Leu Asp Glu His Ile Asn Val Ser Pro Lys Ala Val Lys
465                 470                 475                 480 
Asn Thr Asp Gly Lys Gln Asp Leu Asp Lys Leu Ile Lys Val Asn Pro
                485                 490                 495     
Glu Ile Phe Thr Asn Asn Gln Arg Asn Gln Asp Leu Ala Asn Leu Ile
            500                 505                 510         
Lys Val Asn Pro Ala Val Ile Arg Asn Asn Gln Ser Gln Asp Leu Glu
        515                 520                 525             
Asn Leu Ile Lys Val Ile Pro Ser Ala Leu Arg Asn Thr Asn Arg Asp
    530                 535                 540                 
Gln Asn Leu Glu Asn Leu Ile Glu Val Asn Ser His Val Ser Glu Asn
545                 550                 555                 560 
Lys Asn Gly Ser Ser Asn Thr Gly Ala Lys Gln Ala Gly Pro Gln Asp
                565                 570                 575     
Thr Val Val Tyr Thr Arg Thr Tyr Val Glu Asn Ser Lys Ser Pro Lys
            580                 585                 590         
Asp Gly Tyr Gln Glu Asn Ile Ser Gly Lys Tyr Ile Gln Thr Val Tyr
        595                 600                 605             
Ser Thr Ser Asp Arg Ser Val Ile Glu Arg Asp Met Cys Thr Tyr Cys
    610                 615                 620                 
Arg Lys Pro Leu Gly Val Glu Thr Lys Met Ile Leu Asp Glu Leu Gln
625                 630                 635                 640 
Ile Cys Cys His Ser Thr Cys Phe Lys Cys Glu Ile Cys Lys Gln Pro
                645                 650                 655     
Leu Glu Asn Leu Gln Ala Gly Asp Ser Ile Trp Ile Tyr Arg Gln Thr
            660                 665                 670         
Ile His Cys Glu Pro Cys Tyr Ser Lys Ile Met Ala Lys Trp Ile Pro
        675                 680                 685             


<210> 7961
<211> 383
<212> PRT
<213> Homo sapiens

<400> 7961
Met Val Phe Lys Ala Ile Ala Asn Gln Gln Ile Pro Gln Gln Pro Glu
 1               5                  10                  15      
Arg His Leu Gly Lys Ser Gly Leu Ser Gln Ser His Val Gln Arg Ala
            20                  25                  30          
Val Cys Asn Thr Trp Ala Lys Tyr Arg Glu Gly Arg Arg Pro Arg Ala
        35                  40                  45              
Val Lys Ile Tyr Thr Ile Asn Leu Glu Ser Gln Tyr Leu Leu Ile Gln
    50                  55                  60                  
Gly Val Pro Ala Val Gly Thr Met Lys Glu Ile Val Glu Arg Phe Ala
65                  70                  75                  80  
Leu His Gly Ala Thr Glu Gln Tyr Asn Val Leu Asp Glu Tyr Pro Ala
                85                  90                  95      
Glu Asp Phe Thr Glu Val Tyr Leu Ile Lys Phe Ile Asn Leu Gln Ser
            100                 105                 110         
Ala Arg Thr Ala Lys Arg Lys Met Asp Glu Gln Ser Phe Leu Gly Gly
        115                 120                 125             
Leu Leu His Val Cys Tyr Ala Pro Ala Phe Glu Thr Val Glu Glu Thr
    130                 135                 140                 
Arg Lys Lys Pro Glu Val Arg Lys Ala Tyr Val Val Arg Thr Thr Glu
145                 150                 155                 160 
Asn Lys Gly Phe Lys Pro His His Tyr Val Thr Lys Lys Leu Val Thr
                165                 170                 175     
Glu His Lys Asp Thr Glu Asn Phe Arg Gln Asp Phe His Ser Glu Met
            180                 185                 190         
Ser Gly Phe Cys Thr Ala Ala Val Asn Pro Ser Ala Gly Asn Ser Asn
        195                 200                 205             
Pro Tyr Leu Pro Tyr Ser Cys Glu Leu Pro Leu Cys Tyr Phe Phe Ser
    210                 215                 220                 
Lys Cys Ile Cys Ser Ser Gly Gly His Val Asp Arg Ala Ser Asp Ser
225                 230                 235                 240 
Ser Lys Asp Asp Arg Asn His Gly Lys Thr Met Gly His Tyr Asn His
                245                 250                 255     
Asn Asp Ser Leu Gln Lys Thr Gln Ile Asn Thr Phe Lys Asn Ser Val
            260                 265                 270         
Ala Tyr Pro Gly Ala Glu Lys Ala Ile Thr Pro Ser Glu Ala Val Asp
        275                 280                 285             
Asn Arg Phe Met Pro Arg Thr Thr Lys Leu Gln Glu Arg Gln Arg Gly
    290                 295                 300                 
Arg Glu Asp Asp Cys Lys Val Gly Thr Phe Leu Glu Thr Asn Ser Ser
305                 310                 315                 320 
Ser Asn Glu Val Met Thr Gly Pro Leu Leu Pro Asp Ile Ser Lys Val
                325                 330                 335     
Asp Met His Asp Asp Ser Leu Asn Thr Thr Ala Asn Leu Ile Trp Asn
            340                 345                 350         
Lys Leu Lys Gln Val Ile Ser Ser Ala Lys Ala Ser Gly Asp Lys Pro
        355                 360                 365             
Ala Glu Val His Thr Ser His Pro Leu Lys Gln Arg Arg Arg Ile
    370                 375                 380             


<210> 7962
<211> 929
<212> PRT
<213> Homo sapiens

<400> 7962
Met Pro Ser Glu Lys Val Leu Val Ala Asn Ser Pro Arg Thr Val Arg
 1               5                  10                  15      
Gly Gly Asn Trp Leu Gln Ser Trp Arg Ala Gln Ala Tyr Ala Val Arg
            20                  25                  30          
Ser Gly Pro Leu Gly Arg Lys Val Asp Gln Gly Arg Lys His Ala Gln
        35                  40                  45              
Gln Lys Leu Gly Val Asp Lys Glu Lys Ser Arg Asn Phe Leu Asp Ile
    50                  55                  60                  
Asp Pro Glu Glu Asp Ser Gln Phe Asn Ile Lys Val Asp Ala Ala Arg
65                  70                  75                  80  
Ala Ser Gly Arg Gln Pro Cys Pro Gly His Asp Arg Arg Thr Gln Leu
                85                  90                  95      
Phe Ala Val Ser Ala Pro Ser Arg Asp Leu Gln Asn Cys Ser Arg Glu
            100                 105                 110         
Arg Phe Pro Lys Pro Asn Leu Val Trp Pro Ser Gly Ala Ala Val Gln
        115                 120                 125             
Ser Thr Leu Leu Lys Gly Asp Arg Trp Leu Leu Leu Arg Glu Met Trp
    130                 135                 140                 
Glu Ser Pro Arg Gly Ala Arg Ser Gly Asp Arg Lys Gly Glu Gly Glu
145                 150                 155                 160 
Lys Ser Glu Thr Glu Asp Asn Pro Lys Gly Leu Thr Leu Pro Asp Asp
                165                 170                 175     
Ser Thr Gln Leu Ile Ile Ile Ser Leu Ser Val Cys Leu Ser Leu Arg
            180                 185                 190         
Leu Val Ser Pro Cys Ala Phe Tyr Cys Asp Leu Pro Val Gly Thr Leu
        195                 200                 205             
Ser Pro Ser Arg Ser Ser Met Glu Arg Arg Ser Glu Ser Pro Cys Leu
    210                 215                 220                 
Arg Asp Ser Pro Asp Arg Arg Ser Gly Ser Pro Asp Val Lys Gly Pro
225                 230                 235                 240 
Pro Pro Val Lys Val Ala Arg Leu Glu Gln Asn Gly Ser Pro Met Gly
                245                 250                 255     
Ala Arg Gly Arg Pro Asn Gly Ala Val Ala Lys Ala Val Gly Gly Leu
            260                 265                 270         
Met Ile Pro Val Phe Cys Val Val Glu Gln Leu Asp Gly Ser Leu Glu
        275                 280                 285             
Tyr Asp Asn Arg Glu Glu His Ala Glu Phe Val Leu Val Arg Lys Asp
    290                 295                 300                 
Val Leu Phe Ser Gln Leu Val Glu Thr Ala Leu Leu Ala Leu Gly Tyr
305                 310                 315                 320 
Ser His Ser Ser Ala Ala Gln Ala Gln Gly Ile Ile Lys Leu Gly Arg
                325                 330                 335     
Trp Asn Pro Leu Pro Leu Ser Tyr Val Thr Asp Ala Pro Asp Ala Thr
            340                 345                 350         
Val Ala Asp Met Leu Gln Asp Val Tyr His Val Val Thr Leu Lys Ile
        355                 360                 365             
Gln Leu Gln Ser Cys Ser Lys Leu Glu Asp Leu Pro Ala Glu Gln Trp
    370                 375                 380                 
Asn His Ala Thr Val Arg Asn Ala Leu Lys Glu Leu Leu Lys Glu Met
385                 390                 395                 400 
Asn Gln Ser Thr Leu Ala Lys Glu Cys Pro Leu Ser Gln Ser Met Ile
                405                 410                 415     
Ser Ser Ile Val Asn Ser Thr Tyr Tyr Ala Asn Val Ser Ala Thr Lys
            420                 425                 430         
Cys Gln Glu Phe Gly Arg Trp Tyr Lys Lys Tyr Lys Lys Ile Lys Val
        435                 440                 445             
Glu Arg Val Glu Arg Glu Asn Leu Ser Asp Tyr Cys Val Leu Gly Gln
    450                 455                 460                 
Arg Pro Met His Leu Pro Asn Met Asn Gln Leu Ala Ser Leu Gly Lys
465                 470                 475                 480 
Thr Asn Glu Gln Ser Pro His Ser Gln Ile His His Ser Thr Pro Ile
                485                 490                 495     
Arg Asn Gln Val Pro Ala Leu Gln Pro Ile Met Ser Pro Gly Leu Leu
            500                 505                 510         
Ser Pro Gln Leu Ser Pro Gln Leu Val Arg Gln Gln Ile Ala Met Ala
        515                 520                 525             
His Leu Ile Asn Gln Gln Ile Ala Val Ser Arg Leu Leu Ala His Gln
    530                 535                 540                 
His Pro Gln Ala Ile Asn Gln Gln Phe Leu Asn His Pro Pro Ile Pro
545                 550                 555                 560 
Arg Ala Val Lys Pro Glu Pro Thr Asn Ser Ser Val Glu Val Ser Pro
                565                 570                 575     
Asp Ile Tyr Gln Gln Val Arg Asp Glu Leu Lys Arg Ala Ser Val Ser
            580                 585                 590         
Gln Ala Val Phe Ala Arg Val Ala Phe Asn Arg Thr Gln Gly Leu Leu
        595                 600                 605             
Ser Glu Ile Leu Arg Lys Glu Glu Asp Pro Arg Thr Ala Ser Gln Ser
    610                 615                 620                 
Leu Leu Val Asn Leu Arg Ala Met Gln Asn Phe Leu Asn Leu Pro Glu
625                 630                 635                 640 
Val Glu Arg Asp Arg Ile Tyr Gln Asp Glu Arg Glu Arg Ser Met Asn
                645                 650                 655     
Pro Asn Ala Lys Thr Ser Thr Pro Thr Thr Asp Leu Pro Ile Lys Val
            660                 665                 670         
Asp Gly Ala Asn Ile Asn Ile Thr Ala Ala Ile Tyr Asp Glu Ile Gln
        675                 680                 685             
Gln Glu Met Lys Arg Ala Lys Val Ser Gln Ala Leu Phe Ala Lys Val
    690                 695                 700                 
Ala Ala Asn Lys Ser Gln Gly Trp Leu Cys Glu Leu Leu Arg Trp Lys
705                 710                 715                 720 
Glu Asn Pro Ser Pro Glu Asn Arg Thr Leu Trp Glu Asn Leu Cys Thr
                725                 730                 735     
Ile Arg Arg Phe Leu Asn Leu Pro Gln His Glu Arg Asp Val Ile Tyr
            740                 745                 750         
Glu Glu Glu Ser Arg His His His Ser Glu Arg Met Gln His Val Val
        755                 760                 765             
Gln Leu Pro Pro Glu Pro Val Gln Val Leu His Arg Gln Gln Ser Gln
    770                 775                 780                 
Pro Ala Lys Glu Ser Ser Pro Pro Arg Glu Glu Ala Pro Pro Pro Pro
785                 790                 795                 800 
Pro Pro Thr Glu Asp Ser Cys Ala Lys Lys Pro Arg Ser Arg Thr Lys
                805                 810                 815     
Ile Ser Leu Glu Ala Leu Gly Ile Leu Gln Ser Phe Ile His Asp Val
            820                 825                 830         
Gly Leu Tyr Pro Asp Gln Glu Ala Ile His Thr Leu Ser Ala Gln Leu
        835                 840                 845             
Asp Leu Pro Lys His Thr Ile Ile Lys Phe Phe Gln Asn Gln Arg Tyr
    850                 855                 860                 
His Val Lys His His Gly Lys Leu Lys Glu His Leu Gly Ser Ala Val
865                 870                 875                 880 
Asp Val Ala Glu Tyr Lys Asp Glu Glu Leu Leu Thr Glu Ser Glu Glu
                885                 890                 895     
Asn Asp Ser Glu Glu Gly Ser Glu Glu Met Tyr Lys Val Glu Ala Glu
            900                 905                 910         
Glu Glu Asn Ala Asp Lys Ser Lys Ala Ala Pro Ala Glu Ile Asp Gln
        915                 920                 925             
Arg
    


<210> 7963
<211> 715
<212> PRT
<213> Homo sapiens

<400> 7963
Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn
 1               5                  10                  15      
Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys
            20                  25                  30          
Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg
        35                  40                  45              
Arg Asp Ile Ser Ser Thr Leu Ile Ala Leu Ala Asp Lys His Ala Thr
    50                  55                  60                  
Leu Ser Val Cys Tyr Lys Ala Gly Pro Gly Ala Asp Asn Gly Glu Glu
65                  70                  75                  80  
Gly Glu Ile Glu Glu Glu Met Glu Asn Pro Glu Met Val Asp Leu Pro
                85                  90                  95      
Glu Lys Leu Lys His Gln Leu Arg His Arg Glu Leu Phe Leu Ser Arg
            100                 105                 110         
Gln Leu Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val
        115                 120                 125             
Thr Leu Leu Asn Glu Thr Glu Ser Leu Lys Ser Tyr Leu Glu Arg Glu
    130                 135                 140                 
Asp Phe Phe Phe Tyr Ser Leu Val Tyr Asp Pro Gln Gln Lys Thr Leu
145                 150                 155                 160 
Leu Ala Asp Lys Gly Glu Ile Arg Val Gly Asn Arg Tyr Gln Ala Asp
                165                 170                 175     
Ile Thr Asp Leu Leu Lys Glu Gly Glu Glu Asp Gly Arg Asp Gln Ser
            180                 185                 190         
Arg Leu Glu Thr Gln Val Trp Glu Ala His Asn Pro Leu Thr Asp Lys
        195                 200                 205             
Gln Ile Asp Gln Phe Leu Val Val Ala Arg Ser Val Gly Thr Phe Ala
    210                 215                 220                 
Arg Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met
225                 230                 235                 240 
Ser Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp
                245                 250                 255     
Thr Leu His Lys Asn Ile Tyr Asp Ile Ser Lys Ala Ile Ser Ala Leu
            260                 265                 270         
Val Pro Gln Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp
        275                 280                 285             
Ser Ala Ser Glu Ala Asn Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly
    290                 295                 300                 
Lys Asp Phe Thr Asp Ile Gln Gln Asp Phe Leu Pro Trp Lys Ser Leu
305                 310                 315                 320 
Thr Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr
                325                 330                 335     
Val Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys
            340                 345                 350         
Gln Val Tyr Ile Pro Asn Tyr Asn Lys Pro Asn Pro Asn Gln Ile Ser
        355                 360                 365             
Val Asn Asn Val Lys Ala Gly Val Val Asn Gly Thr Gly Ala Pro Gly
    370                 375                 380                 
Gln Ser Pro Gly Ala Gly Arg Ala Cys Glu Ser Cys Tyr Thr Thr Gln
385                 390                 395                 400 
Ser Tyr Gln Trp Tyr Ser Trp Gly Pro Pro Asn Met Gln Cys Arg Leu
                405                 410                 415     
Cys Ala Ser Cys Trp Thr Tyr Trp Lys Lys Tyr Gly Gly Leu Lys Met
            420                 425                 430         
Pro Thr Arg Leu Asp Gly Glu Arg Pro Gly Pro Asn Arg Ser Asn Met
        435                 440                 445             
Ser Pro His Gly Leu Pro Ala Arg Ser Ser Gly Ser Pro Lys Phe Ala
    450                 455                 460                 
Met Lys Thr Arg Gln Ala Phe Tyr Leu His Thr Thr Lys Leu Thr Arg
465                 470                 475                 480 
Ile Ala Arg Arg Leu Cys Arg Glu Ile Leu Arg Pro Trp His Ala Ala
                485                 490                 495     
Arg Asn Pro Tyr Leu Pro Ile Asn Ser Ala Ala Ile Lys Ala Glu Cys
            500                 505                 510         
Thr Ala Arg Leu Pro Glu Ala Ser Gln Ser Pro Leu Val Leu Lys Gln
        515                 520                 525             
Ala Val Arg Lys Pro Leu Glu Ala Val Leu Arg Tyr Leu Glu Thr His
    530                 535                 540                 
Pro Arg Pro Pro Lys Pro Asp Pro Val Lys Ser Val Ser Ser Val Leu
545                 550                 555                 560 
Ser Ser Leu Thr Pro Ala Lys Val Ala Pro Val Ile Asn Asn Gly Ser
                565                 570                 575     
Pro Thr Ile Leu Gly Lys Arg Ser Tyr Glu Gln His Asn Gly Val Asp
            580                 585                 590         
Gly Asn Met Lys Lys Arg Leu Leu Met Pro Ser Arg Gly Leu Ala Asn
        595                 600                 605             
His Gly Gln Thr Arg His Met Gly Pro Ser Arg Asn Leu Leu Leu Asn
    610                 615                 620                 
Gly Lys Ser Tyr Pro Thr Lys Val Arg Leu Ile Arg Gly Gly Ser Leu
625                 630                 635                 640 
Pro Pro Val Lys Arg Arg Arg Met Asn Trp Ile Asp Ala Pro Gly Asp
                645                 650                 655     
Val Phe Tyr Met Pro Lys Glu Glu Thr Arg Lys Ile Arg Lys Leu Leu
            660                 665                 670         
Ser Ser Ser Glu Thr Lys Arg Ala Ala Arg Arg Pro Tyr Lys Pro Ile
        675                 680                 685             
Ala Leu Arg Gln Ser Gln Ala Leu Pro Pro Arg Pro Pro Pro Pro Ala
    690                 695                 700                 
Pro Val Asn Asp Glu Pro Ile Val Ile Glu Asp
705                 710                 715 


<210> 7964
<211> 146
<212> PRT
<213> Homo sapiens

<400> 7964
Met Gln Val Leu Thr Lys Arg Tyr Pro Lys Asn Cys Leu Leu Thr Val
 1               5                  10                  15      
Met Asp Arg Tyr Ala Ala Glu Val His Asn Met Glu Gln Val Val Met
            20                  25                  30          
Ile Pro Ser Leu Leu Arg Asp Val Gln Leu Ser Gly Pro Gly Gly Gln
        35                  40                  45              
Ala Gln Ala Glu Ala Pro Asp Leu Tyr Thr Tyr Phe Thr Met Leu Lys
    50                  55                  60                  
Ala Ile Cys Val Asp Val Asp His Gly Leu Leu Pro Arg Glu Glu Trp
65                  70                  75                  80  
Gln Ala Lys Val Ala Gly Ser Glu Glu Asn Gly Thr Ala Glu Thr Glu
                85                  90                  95      
Glu Val Glu Asp Glu Ser Ala Ser Gly Glu Leu Asp Leu Glu Ala Gln
            100                 105                 110         
Phe His Leu His Phe Ser Ser Leu His His Ile Leu Met His Leu Thr
        115                 120                 125             
Glu Lys Ala Gln Glu Val Thr Arg Lys Tyr Gln Glu Met Thr Gly Gln
    130                 135                 140                 
Val Trp
145     


<210> 7965
<211> 1698
<212> PRT
<213> Homo sapiens

<400> 7965
Met Val Gly Glu Leu Arg Tyr Arg Glu Phe Arg Val Pro Leu Gly Pro
 1               5                  10                  15      
Gly Leu His Ala Tyr Pro Asp Glu Leu Ile Arg Gln Arg Val Gly His
            20                  25                  30          
Asp Gly His Pro Glu Tyr Gln Ile Arg Trp Leu Ile Leu Arg Arg Gly
        35                  40                  45              
Asp Glu Gly Asp Gly Gly Ser Gly Gln Val Asp Cys Lys Ala Glu His
    50                  55                  60                  
Ile Leu Leu Trp Met Ser Lys Asp Glu Ile Tyr Ala Asn Cys His Lys
65                  70                  75                  80  
Met Leu Gly Glu Asp Gly Gln Val Ile Gly Pro Ser Gln Glu Ser Ala
                85                  90                  95      
Gly Glu Val Gly Ala Leu Asp Lys Ser Val Leu Glu Glu Met Glu Thr
            100                 105                 110         
Asp Val Lys Ser Leu Ile Gln Arg Ala Leu Arg Gln Leu Glu Glu Cys
        115                 120                 125             
Val Gly Thr Ile Pro Pro Ala Pro Leu Leu His Thr Val His Val Leu
    130                 135                 140                 
Ser Ala Tyr Ala Ser Ile Glu Pro Leu Thr Gly Val Phe Lys Asp Pro
145                 150                 155                 160 
Arg Val Leu Asp Leu Leu Met His Met Leu Ser Ser Pro Asp Tyr Gln
                165                 170                 175     
Ile Arg Trp Ser Ala Gly Arg Met Ile Gln Ala Leu Ser Ser His Asp
            180                 185                 190         
Ala Gly Thr Arg Thr Gln Ile Leu Leu Ser Leu Ser Gln Gln Glu Ala
        195                 200                 205             
Ile Glu Lys His Leu Asp Phe Asp Ser Arg Cys Ala Leu Leu Ala Leu
    210                 215                 220                 
Phe Ala Gln Ala Thr Leu Ser Glu His Pro Met Ser Phe Glu Gly Ile
225                 230                 235                 240 
Gln Leu Pro Gln Val Pro Gly Arg Val Leu Phe Ser Leu Val Lys Arg
                245                 250                 255     
Tyr Leu His Val Thr Ser Leu Leu Asp Gln Leu Asn Asp Ser Ala Ala
            260                 265                 270         
Glu Pro Gly Ala Gln Asn Thr Ser Ala Pro Glu Glu Leu Ser Gly Glu
        275                 280                 285             
Arg Gly Gln Leu Glu Leu Glu Phe Ser Met Ala Met Gly Thr Leu Ile
    290                 295                 300                 
Ser Glu Leu Val Gln Ala Met Arg Trp Asp Gln Ala Ser Asp Arg Pro
305                 310                 315                 320 
Arg Ser Ser Ala Arg Ser Pro Gly Ser Ile Phe Gln Pro Gln Leu Ala
                325                 330                 335     
Asp Val Ser Pro Gly Leu Pro Ala Ala Gln Ala Gln Pro Ser Phe Arg
            340                 345                 350         
Arg Ser Arg Arg Phe Arg Pro Arg Ser Glu Phe Ala Ser Gly Asn Thr
        355                 360                 365             
Tyr Ala Leu Tyr Val Arg Asp Thr Leu Gln Pro Gly Met Arg Val Arg
    370                 375                 380                 
Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala Gly Asp Glu Gly Glu Phe
385                 390                 395                 400 
Arg Gln Ser Asn Asn Gly Val Pro Pro Val Gln Val Phe Trp Glu Ser
                405                 410                 415     
Thr Gly Arg Thr Tyr Trp Val His Trp His Met Leu Glu Ile Leu Gly
            420                 425                 430         
Phe Glu Glu Asp Ile Glu Asp Met Val Glu Ala Asp Glu Tyr Gln Gly
        435                 440                 445             
Ala Val Ala Ser Arg Val Leu Gly Arg Ala Leu Pro Ala Trp Arg Trp
    450                 455                 460                 
Arg Pro Met Thr Glu Leu Tyr Ala Val Pro Tyr Val Leu Pro Glu Asp
465                 470                 475                 480 
Glu Asp Thr Glu Glu Cys Glu His Leu Thr Leu Ala Glu Trp Trp Glu
                485                 490                 495     
Leu Leu Phe Phe Ile Lys Lys Leu Asp Gly Pro Asp His Gln Glu Val
            500                 505                 510         
Leu Gln Ile Leu Gln Glu Asn Leu Asp Gly Glu Ile Leu Asp Asp Glu
        515                 520                 525             
Ile Leu Ala Glu Leu Ala Val Pro Ile Glu Leu Ala Gln Asp Leu Leu
    530                 535                 540                 
Leu Thr Leu Pro Gln Arg Leu Asn Asp Ser Ala Leu Arg Asp Leu Ile
545                 550                 555                 560 
Asn Cys His Val Tyr Lys Lys Tyr Gly Pro Glu Ala Leu Ala Gly Asn
                565                 570                 575     
Gln Ala Tyr Pro Ser Leu Leu Glu Ala Gln Glu Asp Val Leu Leu Leu
            580                 585                 590         
Asp Ala Gln Ala Gln Ala Lys Asp Ser Glu Asp Ala Ala Lys Val Glu
        595                 600                 605             
Ala Lys Glu Pro Pro Ser Gln Ser Pro Asn Thr Pro Leu Gln Arg Leu
    610                 615                 620                 
Val Glu Gly Tyr Gly Pro Ala Gly Lys Ile Leu Leu Asp Leu Glu Gln
625                 630                 635                 640 
Ala Leu Ser Ser Glu Gly Thr Gln Glu Asn Lys Val Lys Pro Leu Leu
                645                 650                 655     
Leu Gln Leu Gln Arg Gln Pro Gln Pro Phe Leu Ala Leu Met Gln Ser
            660                 665                 670         
Leu Asp Thr Pro Glu Thr Asn Arg Thr Leu His Leu Thr Val Leu Arg
        675                 680                 685             
Ile Leu Lys Gln Leu Val Asp Phe Pro Glu Ala Leu Leu Leu Pro Trp
    690                 695                 700                 
His Glu Ala Val Asp Ala Cys Met Ala Cys Leu Arg Ser Pro Asn Thr
705                 710                 715                 720 
Asp Arg Glu Val Leu Gln Glu Leu Ile Phe Phe Leu His Arg Leu Thr
                725                 730                 735     
Ser Val Ser Arg Asp Tyr Ala Val Val Leu Asn Gln Leu Gly Ala Arg
            740                 745                 750         
Asp Ala Ile Ser Lys Ala Leu Glu Lys His Leu Gly Lys Leu Glu Leu
        755                 760                 765             
Ala Gln Glu Leu Arg Asp Met Val Phe Lys Cys Glu Lys His Ala His
    770                 775                 780                 
Leu Tyr Arg Lys Leu Ile Thr Asn Ile Leu Gly Gly Cys Ile Gln Met
785                 790                 795                 800 
Val Leu Gly Gln Ile Glu Asp His Arg Arg Thr His Arg Pro Ile Asn
                805                 810                 815     
Ile Pro Phe Phe Asp Val Phe Leu Arg Tyr Leu Cys Gln Gly Ser Ser
            820                 825                 830         
Val Glu Val Lys Glu Asp Lys Cys Trp Glu Lys Val Glu Val Ser Ser
        835                 840                 845             
Asn Pro His Arg Ala Ser Lys Leu Thr Asp His Asn Pro Lys Thr Tyr
    850                 855                 860                 
Trp Glu Ser Asn Gly Ser Ala Gly Ser His Tyr Ile Thr Leu His Met
865                 870                 875                 880 
Arg Arg Gly Ile Leu Ile Arg Gln Leu Thr Leu Leu Val Ala Ser Glu
                885                 890                 895     
Asp Ser Ser Tyr Met Pro Ala Arg Val Val Val Cys Gly Gly Asp Ser
            900                 905                 910         
Thr Ser Ser Leu His Thr Glu Leu Asn Ser Val Asn Val Met Pro Ser
        915                 920                 925             
Ala Ser Arg Val Ile Leu Leu Glu Asn Leu Thr Arg Phe Trp Pro Ile
    930                 935                 940                 
Ile Gln Ile Arg Ile Lys Arg Cys Gln Gln Gly Gly Ile Asp Thr Arg
945                 950                 955                 960 
Ile Arg Gly Leu Glu Ile Leu Gly Pro Lys Pro Thr Phe Trp Pro Val
                965                 970                 975     
Phe Arg Glu Gln Leu Cys Arg His Thr Arg Leu Phe Tyr Met Val Arg
            980                 985                 990         
Ala Gln Ala Trp Ser Gln Asp Met Ala Glu Asp Arg Arg Ser Leu Leu
        995                 1000                1005            
His Leu Ser Ser Arg Leu Asn Gly Ala Leu Arg Gln Glu Gln Asn Phe
    1010                1015                1020                
Ala Asp Arg Phe Leu Pro Asp Asp Glu Ala Ala Gln Ala Leu Gly Lys
1025                1030                1035                1040
Thr Cys Trp Glu Ala Leu Val Ser Pro Val Val Gln Asn Ile Thr Ser
                1045                1050                1055    
Pro Asp Glu Asp Gly Ile Ser Pro Leu Gly Trp Leu Leu Asp Gln Tyr
            1060                1065                1070        
Leu Glu Cys Gln Glu Ala Val Phe Asn Pro Gln Ser Arg Gly Pro Ala
        1075                1080                1085            
Phe Phe Ser Arg Val Arg Arg Leu Thr His Leu Leu Val His Val Glu
    1090                1095                1100                
Pro Cys Glu Ala Pro Pro Pro Val Val Ala Thr Pro Arg Pro Lys Gly
1105                1110                1115                1120
Arg Asn Arg Ser His Asp Trp Ser Ser Leu Ala Thr Arg Gly Leu Pro
                1125                1130                1135    
Ser Ser Ile Met Arg Asn Leu Thr Arg Cys Trp Arg Ala Val Val Glu
            1140                1145                1150        
Lys Gln Val Asn Asn Phe Leu Thr Ser Ser Trp Arg Asp Asp Asp Phe
        1155                1160                1165            
Val Pro Arg Tyr Cys Glu His Phe Asn Ile Leu Gln Asn Ser Ser Ser
    1170                1175                1180                
Glu Leu Phe Gly Pro Arg Ala Ala Phe Leu Leu Ala Leu Gln Asn Gly
1185                1190                1195                1200
Cys Ala Gly Ala Leu Leu Lys Leu Pro Phe Leu Lys Ala Ala His Val
                1205                1210                1215    
Ser Glu Gln Phe Ala Arg His Ile Asp Gln Gln Ile Gln Gly Ser Arg
            1220                1225                1230        
Ile Gly Gly Ala Gln Glu Met Glu Arg Leu Ala Gln Leu Gln Gln Cys
        1235                1240                1245            
Leu Gln Ala Val Leu Ile Phe Ser Gly Leu Glu Ile Ala Thr Thr Phe
    1250                1255                1260                
Glu His Tyr Tyr Gln His Tyr Met Ala Asp Arg Leu Leu Gly Val Val
1265                1270                1275                1280
Ser Ser Trp Leu Glu Gly Ala Val Leu Glu Gln Ile Gly Pro Cys Phe
                1285                1290                1295    
Pro Asn Arg Leu Pro Gln Gln Met Leu Gln Ser Leu Ser Thr Ser Lys
            1300                1305                1310        
Glu Leu Gln Arg Gln Phe His Val Tyr Gln Leu Gln Gln Leu Asp Gln
        1315                1320                1325            
Glu Leu Leu Lys Leu Glu Asp Thr Glu Lys Lys Ile Gln Val Gly Leu
    1330                1335                1340                
Gly Ala Ser Gly Lys Glu His Lys Ser Glu Lys Glu Glu Glu Ala Gly
1345                1350                1355                1360
Ala Ala Ala Val Val Asp Val Ala Glu Gly Glu Glu Glu Glu Glu Glu
                1365                1370                1375    
Asn Glu Asp Leu Tyr Tyr Glu Gly Ala Met Pro Glu Val Ser Val Leu
            1380                1385                1390        
Val Leu Ser Arg His Ser Trp Pro Val Ala Ser Ile Cys His Thr Leu
        1395                1400                1405            
Asn Pro Arg Thr Cys Leu Pro Ser Tyr Leu Arg Gly Thr Leu Asn Arg
    1410                1415                1420                
Tyr Ser Asn Phe Tyr Asn Lys Ser Gln Ser His Pro Ala Leu Glu Arg
1425                1430                1435                1440
Gly Ser Gln Arg Arg Leu Gln Trp Thr Trp Leu Gly Trp Ala Glu Leu
                1445                1450                1455    
Gln Phe Gly Asn Gln Thr Leu His Val Ser Thr Val Gln Met Trp Leu
            1460                1465                1470        
Leu Leu Tyr Leu Asn Asp Leu Lys Ala Val Ser Val Glu Ser Leu Leu
        1475                1480                1485            
Ala Phe Ser Gly Leu Ser Ala Asp Met Leu Asn Gln Ala Ile Gly Pro
    1490                1495                1500                
Leu Thr Ser Ser Arg Gly Pro Leu Asp Leu His Glu Gln Lys Asp Ile
1505                1510                1515                1520
Pro Gly Gly Val Leu Lys Ile Arg Asp Gly Ser Lys Glu Pro Arg Ser
                1525                1530                1535    
Arg Trp Asp Ile Val Arg Leu Ile Pro Pro Gln Thr Tyr Leu Gln Ala
            1540                1545                1550        
Glu Gly Glu Asp Gly Gln Asn Leu Glu Lys Arg Arg Asn Leu Leu Asn
        1555                1560                1565            
Cys Leu Ile Val Arg Ile Leu Lys Ala His Gly Asp Glu Gly Leu His
    1570                1575                1580                
Ile Asp Gln Leu Val Cys Leu Val Leu Glu Ala Trp Gln Lys Gly Pro
1585                1590                1595                1600
Cys Pro Pro Arg Gly Leu Val Ser Ser Leu Gly Lys Gly Ser Ala Cys
                1605                1610                1615    
Ser Ser Thr Asp Val Leu Ser Cys Ile Leu His Leu Leu Gly Lys Gly
            1620                1625                1630        
Thr Leu Arg Arg His Asp Asp Arg Pro Gln Val Leu Ser Tyr Ala Val
        1635                1640                1645            
Pro Val Thr Val Met Glu Pro His Thr Glu Ser Leu Asn Pro Gly Ser
    1650                1655                1660                
Ser Gly Pro Asn Pro Pro Leu Thr Phe His Thr Leu Gln Ile Arg Ser
1665                1670                1675                1680
Arg Gly Val Pro Tyr Ala Ser Cys Thr Ala Thr Gln Ser Phe Ser Thr
                1685                1690                1695    
Phe Arg
        


<210> 7966
<211> 702
<212> PRT
<213> Homo sapiens

<400> 7966
Met Glu Asp Pro Phe Glu Glu Ala Asp Gln Pro Thr Thr Glu Pro Gly
 1               5                  10                  15      
Met Val Leu Asp Ser Val Glu Ala Gly Asp Thr Thr Pro Pro Thr Lys
            20                  25                  30          
Arg Lys Ser Lys Phe Ser Gly Phe Gly Lys Ile Phe Lys Pro Trp Lys
        35                  40                  45              
Trp Arg Lys Lys Lys Ser Ser Asp Lys Phe Lys Glu Thr Ser Glu Val
    50                  55                  60                  
Leu Glu Arg Lys Ile Ser Met Arg Lys Pro Arg Glu Glu Leu Val Lys
65                  70                  75                  80  
Arg Gly Val Leu Leu Glu Asp Pro Glu Gln Gly Gly Glu Asp Pro Gly
                85                  90                  95      
Lys Pro Ser Asp Ala Met Leu Lys Asn Gly His Thr Thr Pro Ile Gly
            100                 105                 110         
Asn Ala Arg Ser Ser Ser Pro Val Gln Val Glu Glu Glu Pro Val Arg
        115                 120                 125             
Leu Ala Ser Leu Arg Lys Ala Ile Pro Glu Glu Asp Leu Lys Lys Arg
    130                 135                 140                 
Leu Gly Ser Thr Gly Ser Gln Pro Asn Ser Glu Ala Glu Ser Val Pro
145                 150                 155                 160 
Glu Asn Val Pro Lys Pro Pro Leu Leu Pro Pro Lys Arg Pro Leu Ser
                165                 170                 175     
Ser Ser His Glu Ala Ser Glu Gly Gln Ala Lys Asp Ala Thr Ser Ser
            180                 185                 190         
Gly Gly Thr Ala Arg Phe Ile Ile Ser Thr Ser Ile Thr Thr Ala Pro
        195                 200                 205             
Ala Ala Thr Thr Ala Ala Thr Ser Leu Ala Lys Thr Val Asn Leu Ser
    210                 215                 220                 
Val Thr Pro Ser Pro Ala Pro Arg Thr Leu Pro Ala Ala Pro Ala Ser
225                 230                 235                 240 
Thr Asn Thr Thr Ala Thr Pro Ser Leu Thr His Met Val Pro Ala Lys
                245                 250                 255     
Gln Pro Pro Ile Pro Pro Pro Lys Pro Ala His Arg Asn Ser Asn Pro
            260                 265                 270         
Val Ile Ala Glu Leu Ser Gln Ala Ile Asn Ser Gly Thr Leu Leu Ser
        275                 280                 285             
Lys Pro Ser Pro Pro Leu Pro Pro Lys Arg Gly Ile Pro Ser Thr Ser
    290                 295                 300                 
Val Pro Thr Leu Glu Ser Ala Ala Ala Ile Thr Thr Lys Thr Pro Ser
305                 310                 315                 320 
Asp Glu Arg Glu Lys Ser Thr Cys Ser Met Gly Ser Glu Leu Leu Pro
                325                 330                 335     
Met Ile Ser Pro Arg Ser Pro Ser Pro Pro Leu Pro Thr His Ile Pro
            340                 345                 350         
Pro Glu Pro Pro Arg Thr Pro Pro Phe Pro Ala Lys Thr Phe Gln Val
        355                 360                 365             
Val Pro Glu Ile Glu Phe Pro Pro Ser Leu Asp Leu His Gln Glu Ile
    370                 375                 380                 
Pro Gln Gln Glu Asp Gln Lys Lys Glu Val Pro Lys Arg Ile Leu Asp
385                 390                 395                 400 
Gln Asn Phe Gly Glu Pro His Ile Pro Ser Arg Leu Pro Pro Leu Pro
                405                 410                 415     
Leu His Ile Arg Ile Gln Gln Ala Leu Thr Ser Pro Leu Pro Met Thr
            420                 425                 430         
Pro Ile Leu Glu Gly Ser His Arg Ala His Ser Leu Leu Phe Glu Asn
        435                 440                 445             
Ser Asp Ser Phe Ser Glu Asp Ser Ser Thr Leu Gly Arg Thr Arg Ser
    450                 455                 460                 
Leu Pro Ile Thr Ile Glu Met Leu Lys Val Pro Asp Asp Glu Glu Glu
465                 470                 475                 480 
Glu Glu Gln Thr Cys Pro Ser Thr Phe Ser Glu Glu Met Thr Pro Thr
                485                 490                 495     
Ser Val Ile Pro Lys Leu Pro Gln Cys Leu Arg Glu Glu Glu Glu Lys
            500                 505                 510         
Glu Ser Asp Ser Asp Ser Glu Gly Pro Ile Gln Tyr Arg Asp Glu Glu
        515                 520                 525             
Asp Glu Asp Glu Ser Tyr Gln Ser Ala Leu Ala Asn Lys Val Lys Arg
    530                 535                 540                 
Lys Asp Thr Leu Ala Met Lys Leu Asn His Arg Pro Ser Glu Pro Glu
545                 550                 555                 560 
Leu Asn Leu Asn Ser Trp Pro Cys Lys Ser Lys Glu Glu Trp Asn Glu
                565                 570                 575     
Ile Arg His Gln Ile Gly Asn Thr Leu Ile Arg Arg Leu Ser Gln Arg
            580                 585                 590         
Pro Thr Pro Glu Glu Leu Glu Gln Arg Asn Ile Leu Gln Pro Lys Asn
        595                 600                 605             
Glu Ala Asp Arg Gln Ala Glu Lys Arg Glu Ile Lys Arg Arg Leu Thr
    610                 615                 620                 
Arg Lys Leu Ser Gln Arg Pro Thr Val Ala Glu Leu Leu Ala Arg Lys
625                 630                 635                 640 
Ile Leu Arg Phe Asn Glu Tyr Val Glu Val Thr Asp Ala Gln Asp Tyr
                645                 650                 655     
Asp Arg Arg Ala Asp Lys Pro Trp Thr Lys Leu Thr Pro Ala Asp Lys
            660                 665                 670         
Ala Ala Ile Arg Lys Glu Leu Asn Glu Phe Lys Ser Ser Glu Met Glu
        675                 680                 685             
Val His Glu Glu Ser Lys His Phe Thr Arg Tyr His Arg Pro
    690                 695                 700         


<210> 7967
<211> 318
<212> PRT
<213> Homo sapiens

<400> 7967
Pro Ala Ala Ala Trp Arg Pro Thr Gly Gln Val Gly Phe Pro Gly Glu
 1               5                  10                  15      
Ala Ala Val Glu Ala Glu Glu Ala Ala Ala Glu Ile Trp Lys Gln Tyr
            20                  25                  30          
Leu Thr Ser Leu Asn Trp Leu Ile Val Ala Trp Lys Ile His Leu Arg
        35                  40                  45              
Lys Gln Thr Ser Pro Leu Gln Ser Gln Ala Trp Ser Trp Thr Val Trp
    50                  55                  60                  
Lys Gln Glu Thr Gln His Leu Leu Pro Lys Gly Arg Ala Ser Ser Gln
65                  70                  75                  80  
Ala Leu Ala Arg Ser Ser Ser Pro Gly Asn Gly Glu Lys Lys Lys Ser
                85                  90                  95      
Ser Asp Lys Phe Lys Glu Thr Ser Glu Val Leu Glu Arg Lys Ile Ser
            100                 105                 110         
Met Arg Lys Pro Arg Glu Glu Leu Val Lys Arg Gly Val Leu Leu Glu
        115                 120                 125             
Asp Pro Glu Gln Gly Gly Glu Asp Pro Gly Lys Pro Ser Asp Ala Met
    130                 135                 140                 
Leu Lys Asn Gly His Thr Thr Pro Ile Gly Asn Ala Arg Ser Ser Ser
145                 150                 155                 160 
Pro Val Gln Val Glu Glu Glu Pro Val Arg Leu Ala Ser Leu Arg Lys
                165                 170                 175     
Ala Ile Pro Glu Glu Asp Leu Lys Lys Arg Leu Gly Ser Thr Gly Ser
            180                 185                 190         
Gln Pro Asn Ser Glu Ala Glu Ser Val Pro Glu Asn Val Pro Lys Pro
        195                 200                 205             
Pro Leu Leu Pro Pro Lys Arg Pro Leu Ser Ser Ser His Glu Ala Ser
    210                 215                 220                 
Glu Gly Gln Ala Lys Asp Ala Thr Ser Ser Gly Gly Thr Ala Arg Phe
225                 230                 235                 240 
Ile Ile Ser Thr Ser Ile Thr Thr Ala Pro Ala Ala Thr Thr Ala Ala
                245                 250                 255     
Thr Ser Leu Ala Lys Thr Val Asn Leu Ser Val Thr Pro Ser Pro Ala
            260                 265                 270         
Pro Arg Thr Leu Pro Ala Ala Pro Ala Ser Thr Asn Thr Thr Ala Thr
        275                 280                 285             
Pro Ser Leu Thr His Met Val Pro Ala Lys Gln Pro Pro Ile Pro Pro
    290                 295                 300                 
Pro Lys Pro Ala His Arg Asn Ser Asn Pro Val Ile Gly Lys
305                 310                 315             


<210> 7968
<211> 632
<212> PRT
<213> Homo sapiens

<400> 7968
Ser Leu Pro Gly Ser Pro Ala Pro Ser Gln Arg Cys Phe Lys Pro Tyr
 1               5                  10                  15      
Pro Leu Ile Thr Pro Cys Tyr Ile Lys Thr Thr Thr Arg Gln Leu Ser
            20                  25                  30          
Ser Pro Asn His Ser Pro Ser Gln Ser Pro Asn Gln Ser Pro Arg Ile
        35                  40                  45              
Lys Arg Arg Pro Glu Pro Ser Leu Ser Arg Gly Ser Arg Thr Ala Leu
    50                  55                  60                  
Ala Ser Val Ala Ala Pro Ala Lys Lys His Arg Ala Asp Gly Gly Leu
65                  70                  75                  80  
Ala Ala Gly Leu Ser Arg Ser Ala Asp Trp Thr Glu Glu Leu Gly Ala
                85                  90                  95      
Arg Thr Pro Arg Val Gly Gly Ser Ala His Leu Leu Glu Arg Gly Val
            100                 105                 110         
Ala Ser Asp Ser Gly Gly Gly Val Ser Pro Ala Leu Ala Ala Lys Ala
        115                 120                 125             
Ser Gly Ala Pro Ala Ala Ala Asp Gly Phe Gln Asn Val Phe Thr Gly
    130                 135                 140                 
Arg Thr Leu Leu Glu Lys Leu Phe Ser Gln Gln Glu Asn Gly Pro Pro
145                 150                 155                 160 
Glu Glu Ala Glu Lys Phe Cys Ser Arg Ile Ile Ala Met Gly Leu Leu
                165                 170                 175     
Leu Pro Phe Ser Asp Cys Phe Arg Glu Pro Cys Asn Gln Asn Ala Gln
            180                 185                 190         
Thr Asn Ala Ala Ser Phe Asp Gln Asp Gln Leu Tyr Thr Trp Ala Ala
        195                 200                 205             
Val Ser Gln Pro Thr His Ser Leu Asp Tyr Ser Glu Gly Gln Phe Pro
    210                 215                 220                 
Arg Arg Val Pro Ser Met Gly Pro Pro Ser Lys Pro Pro Asp Glu Glu
225                 230                 235                 240 
His Arg Leu Glu Asp Ala Glu Thr Glu Ser Gln Ser Ala Val Ser Glu
                245                 250                 255     
Thr Pro Gln Lys Arg Ser Asp Ala Val Gln Lys Glu Val Val Asp Met
            260                 265                 270         
Lys Ser Glu Gly Gln Ala Thr Val Ile Gln Gln Leu Glu Gln Thr Ile
        275                 280                 285             
Glu Asp Leu Arg Thr Lys Ile Ala Glu Leu Glu Arg Gln Tyr Pro Ala
    290                 295                 300                 
Leu Asp Thr Glu Val Ala Ser Gly His Gln Gly Leu Glu Asn Gly Val
305                 310                 315                 320 
Thr Ala Ser Gly Asp Val Cys Leu Glu Ala Leu Arg Pro Arg Ala Thr
                325                 330                 335     
Arg Ala Lys Ser Leu Asp Lys Pro Glu Gln Phe Leu Tyr Glu Leu Ser
            340                 345                 350         
Leu Ile Pro Asn Phe Ser Glu Arg Val Phe Cys Ile Leu Phe Gln Ser
        355                 360                 365             
Thr Phe Ser Glu Ser Ile Cys Ser Ile Arg Arg Lys Leu Glu Leu Leu
    370                 375                 380                 
Gln Lys Leu Cys Glu Thr Leu Lys Asn Gly Pro Gly Val Met Gln Val
385                 390                 395                 400 
Leu Gly Leu Val Leu Ala Phe Gly Asn Tyr Met Asn Gly Gly Asn Lys
                405                 410                 415     
Thr Arg Gly Gln Ala Asp Gly Phe Gly Leu Asp Ile Leu Pro Lys Leu
            420                 425                 430         
Lys Asp Val Lys Ser Ser Asp Asn Ser Arg Ser Leu Leu Ser Tyr Ile
        435                 440                 445             
Val Ser Tyr Tyr Leu Arg Asn Phe Asp Glu Asp Ala Gly Lys Glu Gln
    450                 455                 460                 
Cys Leu Phe Pro Leu Pro Glu Pro Gln Asp Leu Phe Gln Ala Ser Gln
465                 470                 475                 480 
Met Lys Phe Glu Asp Phe Gln Lys Asp Leu Arg Lys Leu Lys Lys Asp
                485                 490                 495     
Leu Lys Ala Cys Glu Val Glu Ala Gly Lys Val Tyr Gln Val Ser Ser
            500                 505                 510         
Lys Glu His Met Gln Pro Phe Lys Glu Asn Met Glu Gln Phe Ile Ile
        515                 520                 525             
Gln Ala Lys Ile Asp Gln Glu Ala Glu Glu Asn Ser Leu Thr Glu Thr
    530                 535                 540                 
His Lys Cys Phe Leu Glu Thr Thr Ala Tyr Phe Phe Met Lys Pro Lys
545                 550                 555                 560 
Leu Gly Glu Lys Glu Val Ser Pro Asn Ala Phe Phe Ser Ile Trp His
                565                 570                 575     
Glu Phe Ser Ser Asp Phe Lys Asp Phe Trp Lys Lys Glu Asn Lys Leu
            580                 585                 590         
Leu Leu Gln Glu Arg Val Lys Glu Ala Glu Glu Val Cys Arg Gln Lys
        595                 600                 605             
Lys Gly Lys Ser Leu Tyr Lys Ile Lys Pro Arg His Asp Ser Gly Ile
    610                 615                 620                 
Lys Ala Lys Ile Ser Met Lys Thr
625                 630         


<210> 7969
<211> 3914
<212> PRT
<213> Homo sapiens

<400> 7969
Met His Thr Asn Asn Ala Lys Ala Met Ser Pro Arg Ala Glu Ala Leu
 1               5                  10                  15      
Lys Ala Leu Val Lys Pro Lys Glu Val Lys Pro Lys Ile Pro Lys Gly
            20                  25                  30          
Val Ser His Lys Leu Asp Arg Leu Ala Tyr Ile Ala His Pro Asn Leu
        35                  40                  45              
Gly Lys Leu Ala Arg Ala Arg Met Ala Lys Gly Leu Arg Leu Cys Arg
    50                  55                  60                  
Pro Lys Ala Lys Ala Lys Asp Gln Thr Lys Ala Gln Ala Ala Ala Pro
65                  70                  75                  80  
Ala Ser Val Ser Ala Gln Ala Pro Lys Ala Ala Gln Cys Pro Thr Lys
                85                  90                  95      
Thr Ser Glu Ser Leu Leu Ile Leu Phe Ala Glu Ile Asp Tyr Trp Glu
            100                 105                 110         
Arg Leu Leu Phe Glu Thr Pro His Tyr Val Val Asn Val Ala Glu Arg
        115                 120                 125             
Ala Glu Asp Leu Arg Ile Leu Arg Glu Asn Leu Leu Leu Val Ala Arg
    130                 135                 140                 
Asp Tyr Asn Arg Ile Ile Ala Met Leu Ser Pro Asp Glu Gln Ala Leu
145                 150                 155                 160 
Phe Lys Glu Arg Ile Arg Leu Leu Asp Lys Lys Ile His Pro Gly Leu
                165                 170                 175     
Lys Lys Leu His Trp Ala Leu Lys Gly Ala Ser Ala Phe Phe Ile Thr
            180                 185                 190         
Glu Cys Arg Ile His Ala Ser Lys Val Gln Met Ile Val Asn Glu Phe
        195                 200                 205             
Lys Ala Ser Thr Leu Thr Ile Gly Trp Arg Ala Gln Glu Met Ser Glu
    210                 215                 220                 
Lys Leu Leu Val Arg Ile Ser Gly Lys Arg Val Tyr Arg Asp Leu Glu
225                 230                 235                 240 
Phe Glu Glu Asp Gln Arg Glu His Arg Ala Ala Val Gln Gln Lys Leu
                245                 250                 255     
Met Asn Leu His Gln Asp Val Val Thr Ile Met Thr Asn Ser Tyr Glu
            260                 265                 270         
Val Phe Lys Asn Asp Gly Pro Glu Ile Gln Gln Gln Trp Met Leu Tyr
        275                 280                 285             
Met Ile Arg Leu Asp Arg Met Met Glu Asp Ala Leu Arg Leu Asn Val
    290                 295                 300                 
Lys Trp Ser Leu Leu Glu Leu Ser Lys Ala Ile Asn Gly Asp Gly Lys
305                 310                 315                 320 
Thr Ser Pro Asn Pro Leu Phe Gln Val Leu Val Ile Leu Lys Asn Asp
                325                 330                 335     
Leu Gln Gly Ser Val Ala Gln Val Glu Phe Ser Pro Thr Leu Gln Thr
            340                 345                 350         
Leu Ala Gly Val Val Asn Asp Ile Gly Asn His Leu Phe Ser Thr Ile
        355                 360                 365             
Ser Val Phe Cys His Leu Pro Asp Ile Leu Thr Lys Arg Lys Leu His
    370                 375                 380                 
Arg Glu Pro Ile Gln Thr Val Val Glu Gln Asp Glu Asp Ile Lys Lys
385                 390                 395                 400 
Ile Gln Thr Gln Ile Ser Ser Gly Met Thr Asn Asn Ala Ser Leu Leu
                405                 410                 415     
Gln Asn Tyr Leu Lys Thr Trp Asp Met Tyr Arg Glu Ile Trp Glu Ile
            420                 425                 430         
Asn Lys Asp Ser Phe Ile His Arg Tyr Gln Arg Leu Asn Pro Pro Val
        435                 440                 445             
Ser Ser Phe Val Ala Asp Ile Ala Arg Tyr Thr Glu Val Ala Asn Asn
    450                 455                 460                 
Val Gln Lys Glu Glu Thr Val Thr Asn Ile Gln Phe Val Leu Leu Asp
465                 470                 475                 480 
Cys Ser His Leu Lys Phe Ser Leu Val Gln His Cys Asn Glu Trp Gln
                485                 490                 495     
Asn Lys Phe Ala Thr Leu Leu Arg Glu Met Ala Ala Gly Arg Leu Leu
            500                 505                 510         
Glu Leu His Thr Tyr Leu Lys Glu Asn Ala Glu Lys Ile Ser Arg Pro
        515                 520                 525             
Pro Gln Thr Leu Glu Glu Leu Gly Val Ser Leu Gln Leu Val Asp Ala
    530                 535                 540                 
Leu Lys His Asp Leu Ala Asn Val Glu Thr Gln Ile Pro Pro Ile His
545                 550                 555                 560 
Glu Gln Phe Ala Ile Leu Glu Lys Tyr Glu Val Pro Val Glu Asp Ser
                565                 570                 575     
Val Leu Glu Met Leu Asp Ser Leu Asn Gly Glu Trp Val Val Phe Gln
            580                 585                 590         
Gln Thr Leu Leu Asp Ser Lys Gln Met Leu Lys Lys His Lys Glu Lys
        595                 600                 605             
Phe Lys Thr Gly Leu Ile His Ser Ala Asp Asp Phe Lys Lys Lys Ala
    610                 615                 620                 
His Thr Leu Leu Glu Asp Phe Glu Phe Lys Gly His Phe Thr Ser Asn
625                 630                 635                 640 
Val Gly Tyr Met Ser Ala Leu Asp Gln Ile Thr Gln Val Arg Ala Met
                645                 650                 655     
Leu Met Ala Met Arg Glu Glu Glu Asn Ser Leu Arg Ala Asn Leu Gly
            660                 665                 670         
Ile Phe Lys Ile Glu Gln Pro Pro Ser Lys Asp Leu Gln Asn Leu Glu
        675                 680                 685             
Lys Val Glu Leu Asp Ala Leu Gln Gln Ile Trp Glu Ile Ala Arg Asp
    690                 695                 700                 
Trp Glu Glu Asn Trp Asn Glu Trp Lys Thr Gly Arg Phe Leu Ile Leu
705                 710                 715                 720 
Gln Thr Glu Thr Met Glu Thr Thr Ala His Gly Leu Phe Arg Arg Leu
                725                 730                 735     
Thr Lys Leu Ala Lys Glu Tyr Lys Asp Arg Asn Trp Glu Ile Ile Glu
            740                 745                 750         
Thr Thr Arg Ser Lys Ile Glu Gln Phe Lys Arg Thr Met Pro Leu Ile
        755                 760                 765             
Ser Asp Leu Arg Asn Pro Ala Leu Arg Glu Arg His Trp Asp Gln Val
    770                 775                 780                 
Arg Asp Glu Ile Gln Arg Glu Phe Asp Gln Glu Ser Glu Ser Phe Thr
785                 790                 795                 800 
Leu Glu Gln Ile Val Glu Leu Gly Met Asp Gln His Val Glu Lys Ile
                805                 810                 815     
Gly Glu Ile Ser Ala Ser Ala Thr Lys Glu Leu Ala Ile Glu Val Ala
            820                 825                 830         
Leu Gln Asn Ile Ala Lys Thr Trp Asp Val Thr Gln Leu Asp Ile Val
        835                 840                 845             
Pro Tyr Lys Asp Lys Gly His His Arg Leu Arg Gly Thr Glu Glu Val
    850                 855                 860                 
Phe Gln Ala Leu Glu Asp Asn Gln Val Ala Leu Ser Thr Met Lys Ala
865                 870                 875                 880 
Ser Arg Phe Val Lys Ala Phe Glu Lys Asp Val Asp His Trp Glu Arg
                885                 890                 895     
Cys Leu Ser Leu Ile Leu Glu Val Ile Glu Met Ile Leu Thr Val Gln
            900                 905                 910         
Arg Gln Trp Met Tyr Leu Glu Asn Ile Phe Leu Gly Glu Asp Ile Arg
        915                 920                 925             
Lys Gln Leu Pro Asn Glu Ser Thr Leu Phe Asp Gln Val Asn Ser Asn
    930                 935                 940                 
Trp Lys Ala Ile Met Asp Arg Met Asn Lys Asp Asn Asn Ala Leu Arg
945                 950                 955                 960 
Ser Thr His His Pro Gly Leu Leu Asp Thr Leu Ile Glu Met Asn Thr
                965                 970                 975     
Ile Leu Glu Asp Ile Gln Lys Ser Leu Asp Met Tyr Leu Glu Thr Lys
            980                 985                 990         
Arg His Ile Phe Pro Arg Phe Tyr Phe Leu Ser Asn Asp Asp Leu Leu
        995                 1000                1005            
Glu Ile Leu Gly Gln Ser Arg Asn Pro Glu Ala Val Gln Pro His Leu
    1010                1015                1020                
Lys Lys Cys Phe Asp Asn Ile Lys Leu Leu Arg Ile Gln Lys Val Gly
1025                1030                1035                1040
Gly Pro Ser Ser Lys Trp Glu Ala Val Gly Met Phe Ser Gly Asp Gly
                1045                1050                1055    
Glu Tyr Ile Asp Phe Leu His Ser Val Phe Leu Glu Gly Pro Val Glu
            1060                1065                1070        
Ser Trp Leu Gly Asp Val Glu Gln Thr Met Arg Val Thr Leu Arg Asp
        1075                1080                1085            
Leu Leu Arg Asn Cys His Leu Ala Leu Arg Lys Phe Leu Asn Lys Arg
    1090                1095                1100                
Asp Lys Trp Val Lys Glu Trp Ala Gly Gln Val Val Ile Thr Ala Ser
1105                1110                1115                1120
Gln Ile Gln Trp Thr Ala Asp Val Thr Lys Cys Leu Leu Thr Ala Lys
                1125                1130                1135    
Glu Arg Ala Asp Lys Lys Ile Leu Lys Val Met Lys Lys Asn Gln Val
            1140                1145                1150        
Ser Ile Leu Asn Lys Tyr Ser Glu Ala Ile Arg Gly Asn Leu Thr Lys
        1155                1160                1165            
Ile Met Arg Leu Lys Ile Val Ala Leu Val Thr Ile Glu Ile His Ala
    1170                1175                1180                
Arg Asp Val Leu Glu Lys Leu Tyr Lys Ser Gly Leu Met Asp Val Asn
1185                1190                1195                1200
Ser Phe Asp Trp Leu Ser Gln Leu Arg Phe Tyr Trp Glu Lys Asp Leu
                1205                1210                1215    
Asp Asp Cys Val Ile Arg Gln Thr Asn Thr Gln Phe Gln Tyr Asn Tyr
            1220                1225                1230        
Glu Tyr Leu Gly Asn Ser Gly Arg Leu Val Ile Thr Pro Leu Thr Asp
        1235                1240                1245            
Arg Cys Tyr Met Thr Leu Thr Thr Ala Leu His Leu His Arg Gly Gly
    1250                1255                1260                
Ser Pro Lys Gly Pro Ala Gly Thr Gly Lys Thr Glu Thr Val Lys Asp
1265                1270                1275                1280
Leu Gly Lys Ala Leu Gly Ile Tyr Val Ile Val Val Asn Cys Ser Glu
                1285                1290                1295    
Gly Leu Asp Tyr Lys Ser Met Gly Arg Met Tyr Ser Gly Leu Ala Gln
            1300                1305                1310        
Thr Gly Ala Trp Gly Cys Phe Asp Glu Phe Asn Arg Ile Asn Ile Glu
        1315                1320                1325            
Val Leu Ser Val Val Ala His Gln Ile Leu Cys Ile Leu Ser Ala Leu
    1330                1335                1340                
Ala Ala Gly Leu Thr His Phe His Phe Asp Gly Phe Glu Ile Asn Leu
1345                1350                1355                1360
Val Trp Ser Cys Gly Ile Phe Ile Thr Met Asn Pro Gly Tyr Ala Gly
                1365                1370                1375    
Arg Thr Glu Leu Pro Glu Asn Leu Lys Ser Met Phe Arg Pro Ile Ala
            1380                1385                1390        
Met Val Val Pro Asp Ser Thr Leu Ile Ala Glu Ile Ile Leu Phe Gly
        1395                1400                1405            
Glu Gly Phe Gly Asn Cys Lys Ile Leu Ala Lys Lys Val Tyr Thr Leu
    1410                1415                1420                
Tyr Ser Leu Ala Val Gln Gln Leu Ser Arg Gln Asp His Tyr Asp Phe
1425                1430                1435                1440
Gly Leu Arg Ala Leu Thr Ser Leu Leu Arg Tyr Ala Gly Lys Lys Arg
                1445                1450                1455    
Arg Leu Gln Pro Asp Leu Thr Asp Glu Glu Val Leu Leu Leu Ser Met
            1460                1465                1470        
Arg Asp Met Asn Ile Ala Lys Leu Thr Ser Val Asp Ala Pro Leu Phe
        1475                1480                1485            
Asn Ala Ile Val Gln Asp Leu Phe Pro Asn Ile Glu Leu Pro Val Ile
    1490                1495                1500                
Asp Tyr Gly Lys Leu Arg Glu Thr Val Glu Gln Glu Ile Arg Asp Met
1505                1510                1515                1520
Gly Leu Gln Ser Thr Pro Phe Thr Leu Thr Lys Val Phe Gln Leu Tyr
                1525                1530                1535    
Glu Thr Lys Asn Ser Arg His Ser Thr Met Ile Val Gly Cys Thr Gly
            1540                1545                1550        
Ser Gly Lys Thr Ala Ser Trp Arg Ile Leu Gln Ala Ser Leu Ser Ser
        1555                1560                1565            
Leu Cys Arg Ala Gly Asp Pro Asn Phe Asn Ile Val Arg Glu Phe Pro
    1570                1575                1580                
Leu Asn Pro Lys Ala Leu Ser Leu Gly Glu Leu Tyr Gly Glu Tyr Asp
1585                1590                1595                1600
Leu Ser Thr Asn Glu Trp Thr Asp Gly Ile Leu Ser Ser Val Met Arg
                1605                1610                1615    
Thr Ala Cys Ala Asp Glu Lys Pro Asp Glu Lys Trp Ile Leu Phe Asp
            1620                1625                1630        
Gly Pro Val Asp Thr Leu Trp Ile Glu Asn Met Asn Ser Val Met Asp
        1635                1640                1645            
Asp Asn Lys Val Leu Thr Leu Ile Asn Gly Glu Arg Ile Ala Met Pro
    1650                1655                1660                
Glu Gln Val Ser Leu Leu Phe Glu Val Glu Asp Leu Ala Met Ala Ser
1665                1670                1675                1680
Pro Ala Thr Val Ser Arg Cys Gly Met Val Tyr Thr Asp Tyr Ala Asp
                1685                1690                1695    
Leu Gly Trp Lys Pro Tyr Val Gln Ser Trp Leu Glu Lys Arg Pro Lys
            1700                1705                1710        
Ala Glu Val Glu Pro Leu Gln Arg Met Phe Glu Lys Leu Ile Asn Lys
        1715                1720                1725            
Met Leu Ala Phe Lys Lys Asp Asn Cys Lys Glu Leu Val Pro Leu Pro
    1730                1735                1740                
Glu Tyr Ser Gly Ile Thr Ser Leu Cys Lys Leu Tyr Ser Ala Leu Ala
1745                1750                1755                1760
Thr Pro Glu Asn Gly Val Asn Pro Ala Asp Gly Glu Asn Tyr Val Thr
                1765                1770                1775    
Met Val Glu Met Thr Phe Val Phe Ser Met Ile Trp Ser Val Cys Ala
            1780                1785                1790        
Ser Val Asp Glu Glu Gly Arg Lys Arg Ile Asp Ser Tyr Leu Arg Glu
        1795                1800                1805            
Ile Glu Gly Ser Phe Pro Asn Lys Asp Thr Val Tyr Glu Tyr Phe Val
    1810                1815                1820                
Asp Pro Lys Ile Arg Ser Trp Thr Ser Phe Glu Asp Lys Leu Pro Lys
1825                1830                1835                1840
Ser Trp Arg Tyr Pro Pro Asn Ala Pro Phe Tyr Lys Ile Met Val Pro
                1845                1850                1855    
Thr Val Asp Thr Val Arg Tyr Asn Tyr Leu Val Ser Ser Leu Val Ala
            1860                1865                1870        
Asn Gln Asn Pro Ile Leu Leu Val Gly Pro Val Gly Thr Gly Lys Thr
        1875                1880                1885            
Ser Ile Ala Gln Ser Val Leu Gln Ser Leu Pro Ser Ser Gln Trp Ser
    1890                1895                1900                
Val Leu Val Val Asn Met Ser Ala Gln Thr Thr Ser Asn Asn Val Gln
1905                1910                1915                1920
Ser Ile Ile Glu Ser Arg Val Glu Lys Arg Thr Lys Gly Val Tyr Val
                1925                1930                1935    
Pro Phe Gly Gly Lys Ser Met Ile Thr Phe Met Asp Asp Leu Asn Met
            1940                1945                1950        
Pro Ala Lys Asp Met Phe Gly Ser Gln Pro Pro Leu Glu Leu Ile Arg
        1955                1960                1965            
Leu Trp Ile Asp Tyr Gly Phe Trp Tyr Asp Arg Thr Lys Gln Thr Ile
    1970                1975                1980                
Lys Tyr Ile Arg Glu Met Phe Leu Met Ala Ala Met Gly Pro Pro Gly
1985                1990                1995                2000
Gly Gly Arg Thr Val Ile Ser Pro Arg Leu Arg Ser Arg Phe Asn Ile
                2005                2010                2015    
Ile Asn Met Thr Phe Pro Thr Val Arg Thr Ser Trp Gly Leu Gln Asp
            2020                2025                2030        
Glu Gly Arg Lys Ser Gln Ile Ile Arg Ile Phe Gly Thr Met Ile Asn
        2035                2040                2045            
Gln Lys Leu Gln Asp Phe Glu Glu Glu Val Lys Pro Ile Gly Asn Val
    2050                2055                2060                
Val Thr Glu Ala Thr Leu Asp Met Tyr Asn Thr Val Val Gln Arg Phe
2065                2070                2075                2080
Leu Pro Thr Pro Thr Lys Met His Tyr Leu Phe Asn Leu Arg Asp Ile
                2085                2090                2095    
Ser Lys Val Phe Gln Gly Met Leu Arg Ala Asn Lys Asp Phe His Asp
            2100                2105                2110        
Thr Lys Ser Ser Ile Thr Arg Leu Trp Ile His Glu Cys Phe Arg Val
        2115                2120                2125            
Phe Ser Asp Arg Leu Val Asp Ala Ala Asp Thr Glu Ala Phe Met Gly
    2130                2135                2140                
Ile Ile Ser Asp Lys Leu Gly Ser Phe Phe Asp Leu Thr Phe His His
2145                2150                2155                2160
Leu Cys Pro Ser Lys Arg Pro Pro Ile Phe Gly Asp Phe Leu Lys Glu
                2165                2170                2175    
Pro Lys Val Tyr Glu Asp Leu Thr Asp Leu Thr Val Leu Lys Thr Val
            2180                2185                2190        
Met Glu Thr Ala Leu Asn Glu Tyr Asn Leu Ser Pro Ser Val Val Pro
        2195                2200                2205            
Met Gln Leu Val Leu Phe Arg Glu Ala Ile Glu His Ile Thr Arg Ile
    2210                2215                2220                
Val Arg Val Ile Gly Gln Pro Arg Gly Asn Met Leu Leu Val Gly Ile
2225                2230                2235                2240
Gly Gly Ser Gly Arg Gln Ser Leu Ala Arg Leu Ala Ser Ser Ile Cys
                2245                2250                2255    
Asp Tyr Thr Thr Phe Gln Ile Glu Val Thr Lys His Tyr Arg Lys Gln
            2260                2265                2270        
Glu Phe Arg Asp Asp Ile Lys Arg Leu Tyr Arg Gln Ala Gly Val Glu
        2275                2280                2285            
Leu Lys Thr Thr Ser Phe Ile Phe Val Asp Thr Gln Ile Ala Asp Glu
    2290                2295                2300                
Ser Phe Leu Glu Asp Ile Asn Asn Ile Leu Ser Ser Gly Glu Val Pro
2305                2310                2315                2320
Asn Leu Tyr Lys Pro Asp Glu Phe Glu Glu Ile Gln Ser His Ile Ile
                2325                2330                2335    
Asp Gln Ala Arg Val Glu Gln Val Pro Glu Ser Ser Asp Ser Leu Phe
            2340                2345                2350        
Ala Tyr Leu Ile Glu Arg Val Gln Asn Asn Leu His Ile Val Leu Cys
        2355                2360                2365            
Leu Ser Pro Met Gly Asp Pro Phe Arg Asn Trp Ile Arg Gln Tyr Pro
    2370                2375                2380                
Ala Leu Val Asn Cys Thr Thr Ile Asn Trp Phe Ser Glu Trp Pro Gln
2385                2390                2395                2400
Glu Ala Leu Leu Glu Val Ala Glu Lys Cys Leu Ile Gly Val Asp Leu
                2405                2410                2415    
Gly Thr Gln Glu Asn Ile His Arg Lys Val Ala Gln Ile Phe Val Thr
            2420                2425                2430        
Met His Trp Ser Val Ala Gln Tyr Ser Gln Lys Met Leu Leu Glu Leu
        2435                2440                2445            
Arg Arg His Asn Tyr Val Thr Pro Thr Lys Tyr Leu Glu Leu Leu Ser
    2450                2455                2460                
Gly Tyr Lys Lys Leu Leu Gly Glu Lys Arg Gln Glu Leu Leu Ala Gln
2465                2470                2475                2480
Ala Asn Lys Leu Arg Thr Gly Leu Phe Lys Ile Asp Glu Thr Arg Glu
                2485                2490                2495    
Lys Val Gln Val Met Ser Leu Glu Leu Glu Asp Ala Lys Lys Lys Val
            2500                2505                2510        
Ala Glu Phe Gln Lys Gln Cys Glu Glu Tyr Leu Val Ile Ile Val Gln
        2515                2520                2525            
Gln Lys Arg Glu Ala Asp Glu Gln Gln Lys Ala Val Thr Ala Asn Ser
    2530                2535                2540                
Glu Lys Ile Ala Val Glu Glu Ile Lys Cys Gln Ala Leu Ala Asp Asn
2545                2550                2555                2560
Ala Gln Lys Asp Leu Glu Glu Ala Leu Pro Ala Leu Glu Glu Ala Met
                2565                2570                2575    
Arg Ala Leu Glu Ser Leu Asn Lys Lys Asp Ile Gly Glu Ile Lys Ser
            2580                2585                2590        
Tyr Gly Arg Pro Pro Ala Gln Val Glu Ile Val Met Gln Ala Val Met
        2595                2600                2605            
Ile Leu Arg Gly Asn Glu Pro Thr Trp Ala Glu Ala Lys Arg Gln Leu
    2610                2615                2620                
Gly Glu Gln Asn Phe Ile Lys Ser Leu Ile Asn Phe Asp Lys Asp Asn
2625                2630                2635                2640
Ile Ser Asp Lys Val Leu Lys Lys Ile Gly Ala Tyr Cys Ala Gln Pro
                2645                2650                2655    
Asp Phe Gln Pro Asp Ile Ile Gly Arg Val Ser Leu Ala Ala Lys Ser
            2660                2665                2670        
Leu Cys Met Trp Val Arg Ala Met Glu Leu Tyr Gly Arg Leu Tyr Arg
        2675                2680                2685            
Val Val Glu Pro Lys Arg Ile Arg Met Asn Ala Ala Leu Ala Gln Leu
    2690                2695                2700                
Arg Glu Lys Gln Ala Ala Leu Ala Glu Ala Gln Glu Lys Leu Arg Glu
2705                2710                2715                2720
Val Ala Glu Lys Leu Glu Met Leu Lys Lys Gln Tyr Asp Glu Lys Leu
                2725                2730                2735    
Ala Gln Lys Glu Glu Leu Arg Lys Lys Ser Glu Glu Met Glu Leu Lys
            2740                2745                2750        
Leu Glu Arg Ala Gly Met Leu Val Ser Gly Leu Ala Gly Glu Lys Ala
        2755                2760                2765            
Arg Trp Glu Glu Thr Val Gln Gly Leu Glu Glu Asp Leu Gly Tyr Leu
    2770                2775                2780                
Val Gly Asp Cys Leu Leu Ala Ala Ala Phe Leu Ser Tyr Met Gly Pro
2785                2790                2795                2800
Phe Leu Thr Asn Tyr Arg Asp Glu Ile Val Asn Gln Ile Trp Ile Gly
                2805                2810                2815    
Lys Ile Trp Glu Leu Gln Val Pro Cys Ser Pro Ser Phe Ala Ile Asp
            2820                2825                2830        
Asn Phe Leu Cys Asn Pro Thr Lys Val Arg Asp Trp Asn Ile Gln Gly
        2835                2840                2845            
Leu Pro Ser Asp Ala Phe Ser Thr Glu Asn Gly Ile Ile Val Thr Arg
    2850                2855                2860                
Gly Asn Arg Trp Ala Leu Met Ile Asp Pro Gln Ala Gln Ala Leu Lys
2865                2870                2875                2880
Trp Ile Lys Asn Met Glu Gly Gly Gln Gly Leu Lys Ile Ile Asp Leu
                2885                2890                2895    
Gln Met Ser Asp Tyr Leu Arg Ile Leu Glu His Ala Ile His Phe Gly
            2900                2905                2910        
Tyr Pro Val Leu Leu Gln Asn Val Gln Glu Tyr Leu Asp Pro Thr Leu
        2915                2920                2925            
Asn Pro Met Leu Asn Lys Ser Val Ala Arg Ile Gly Gly Arg Leu Leu
    2930                2935                2940                
Met Arg Ile Gly Asp Lys Glu Val Glu Tyr Asn Thr Asn Phe Arg Phe
2945                2950                2955                2960
Tyr Ile Thr Thr Lys Leu Ser Asn Pro His Tyr Ser Pro Glu Thr Ser
                2965                2970                2975    
Ala Lys Thr Thr Ile Val Asn Phe Ala Val Lys Glu Gln Gly Leu Glu
            2980                2985                2990        
Ala Gln Leu Leu Gly Ile Val Val Arg Lys Glu Arg Pro Glu Leu Glu
        2995                3000                3005            
Glu Gln Lys Asp Ser Leu Val Ile Asn Ile Ala Ala Gly Lys Arg Lys
    3010                3015                3020                
Leu Lys Glu Leu Glu Asp Glu Ile Leu Arg Leu Leu Asn Glu Ala Thr
3025                3030                3035                3040
Gly Ser Leu Leu Asp Asp Val Gln Leu Val Asn Thr Leu His Thr Ser
                3045                3050                3055    
Lys Ile Thr Ala Thr Glu Val Thr Glu Gln Leu Glu Thr Ser Glu Thr
            3060                3065                3070        
Thr Glu Ile Asn Thr Asp Leu Ala Arg Glu Ala Tyr Arg Pro Cys Ala
        3075                3080                3085            
Gln Arg Ala Ser Ile Leu Phe Phe Val Leu Asn Asp Met Gly Cys Ile
    3090                3095                3100                
Asp Pro Met Tyr Gln Phe Ser Leu Asp Ala Tyr Ile Ser Leu Phe Ile
3105                3110                3115                3120
Leu Ser Ile Asp Lys Ser His Arg Ser Asn Lys Leu Glu Asp Arg Ile
                3125                3130                3135    
Asp Tyr Leu Asn Asp Tyr His Thr Tyr Ala Val Tyr Arg Tyr Thr Cys
            3140                3145                3150        
Arg Thr Leu Phe Glu Arg His Lys Leu Leu Phe Ser Phe His Met Cys
        3155                3160                3165            
Ala Lys Ile Leu Glu Thr Ser Gly Lys Leu Asn Met Asp Glu Tyr Asn
    3170                3175                3180                
Phe Phe Leu Arg Gly Gly Val Val Leu Asp Arg Glu Gly Gln Met Asp
3185                3190                3195                3200
Asn Pro Cys Ser Ser Trp Leu Ala Asp Ala Tyr Trp Asp Asn Ile Thr
                3205                3210                3215    
Glu Leu Asp Lys Leu Thr Asn Phe His Gly Leu Met Asn Ser Phe Glu
            3220                3225                3230        
Gln Tyr Pro Arg Asp Trp His Leu Trp Tyr Thr Asn Ala Ala Pro Glu
        3235                3240                3245            
Lys Ala Met Leu Pro Gly Glu Trp Glu Asn Ala Cys Asn Glu Met Gln
    3250                3255                3260                
Arg Met Leu Ile Val Arg Ser Leu Arg Gln Asp Arg Val Ala Phe Cys
3265                3270                3275                3280
Val Thr Ser Phe Ile Ile Thr Asn Leu Gly Ser Arg Phe Ile Glu Pro
                3285                3290                3295    
Pro Val Leu Asn Met Lys Ser Val Leu Glu Asp Ser Thr Pro Arg Ser
            3300                3305                3310        
Pro Leu Val Phe Ile Leu Ser Pro Gly Val Asp Pro Thr Ser Ala Leu
        3315                3320                3325            
Leu Gln Leu Ala Glu His Met Gly Met Ala Gln Arg Phe His Ala Leu
    3330                3335                3340                
Ser Leu Gly Gln Gly Gln Ala Pro Ile Ala Ala Arg Leu Leu Arg Glu
3345                3350                3355                3360
Gly His Trp Val Phe Leu Ala Asn Cys His Leu Ser Leu Ser Trp Met
                3365                3370                3375    
Pro Asn Leu Asp Lys Leu Val Glu Gln Leu Gln Val Glu Asp Pro His
            3380                3385                3390        
Pro Ser Phe Arg Leu Trp Leu Ser Ser Ile Pro His Pro Asp Phe Pro
        3395                3400                3405            
Ile Ser Ile Leu Gln Val Ser Ile Lys Met Thr Thr Glu Pro Pro Lys
    3410                3415                3420                
Gly Leu Lys Ala Asn Met Thr Arg Leu Tyr Gln Leu Met Ser Glu Pro
3425                3430                3435                3440
Gln Phe Ser Arg Cys Ser Lys Pro Ala Lys Tyr Lys Lys Leu Leu Phe
                3445                3450                3455    
Ser Leu Cys Phe Phe His Ser Val Leu Leu Glu Arg Lys Lys Phe Leu
            3460                3465                3470        
Gln Leu Gly Trp Asn Ile Ile Tyr Gly Phe Asn Asp Ser Asp Phe Glu
        3475                3480                3485            
Val Cys Ile Ser Gln Gly Ser Ser Ser Gln Pro Ser Leu Leu Thr Gln
    3490                3495                3500                
Asn Leu Leu Ser Leu Tyr Leu Asp Glu Tyr Glu Glu Thr Pro Trp Asp
3505                3510                3515                3520
Ala Leu Lys Tyr Leu Ile Ala Gly Ile Asn Tyr Gly Gly His Val Thr
                3525                3530                3535    
Asp Asp Trp Asp Arg Arg Leu Leu Thr Thr Tyr Ile Asn Asp Tyr Phe
            3540                3545                3550        
Cys Asp Gln Ser Leu Ser Thr Pro Phe His Arg Leu Ser Ala Leu Glu
        3555                3560                3565            
Thr Tyr Phe Ile Pro Lys Asp Gly Ser Leu Ala Ser Tyr Lys Glu Tyr
    3570                3575                3580                
Ile Ser Leu Leu Pro Gly Met Asp Pro Pro Glu Ala Phe Gly Gln His
3585                3590                3595                3600
Pro Asn Ala Asp Val Ala Ser Gln Ile Thr Glu Ala Gln Thr Leu Phe
                3605                3610                3615    
Asp Thr Leu Leu Ser Leu Gln Pro Gln Ile Thr Pro Thr Arg Ala Gly
            3620                3625                3630        
Gly Gln Thr Arg Glu Glu Lys Val Lys Arg Ala Gly Pro Gly Gly Gly
        3635                3640                3645            
Lys Val Met Arg Arg Gly Gly Tyr Thr Gln Glu Leu Leu Pro Ala Gln
    3650                3655                3660                
Val Leu Glu Leu Ala Ala Asp Val Lys Gln Lys Ile Pro Glu Met Ile
3665                3670                3675                3680
Asp Tyr Glu Gly Thr Gln Lys Leu Leu Ala Leu Asp Pro Ser Pro Leu
                3685                3690                3695    
Asn Val Val Leu Leu Gln Glu Ile Gln Arg Tyr Asn Thr Leu Met Gln
            3700                3705                3710        
Thr Ile Leu Phe Ser Leu Thr Asp Leu Glu Lys Gly Ile Gln Gly Leu
        3715                3720                3725            
Ile Ala Tyr Pro Ser Gln Lys Pro Leu Ala Ala Trp Thr Arg Asp Leu
    3730                3735                3740                
Ala Met Arg Val Glu Gln Phe Glu Leu Trp Ala Ser Arg Ala Arg Pro
3745                3750                3755                3760
Pro Val Ile Phe Trp Leu Ser Gly Phe Thr Phe Pro Thr Gly Phe Leu
                3765                3770                3775    
Thr Ala Val Leu Gln Ser Ser Ala Arg Gln Asn Asn Val Ser Val Asp
            3780                3785                3790        
Ser Leu Ser Trp Glu Phe Ile Val Ser Thr Val Asp Asp Ser Asn Leu
        3795                3800                3805            
Val Tyr Pro Pro Lys Asp Gly Val Trp Val Arg Gly Leu Tyr Leu Glu
    3810                3815                3820                
Gly Ala Gly Trp Asp Arg Lys Asn Ser Cys Leu Val Glu Ala Glu Pro
3825                3830                3835                3840
Met Gln Leu Val Cys Leu Met Pro Thr Ile His Phe Arg Pro Ala Glu
                3845                3850                3855    
Ser Arg Lys Lys Ser Ala Lys Gly Met Tyr Ser Cys Pro Cys Tyr Tyr
            3860                3865                3870        
Tyr Pro Asn Arg Ala Gly Ser Ser Asp Arg Ala Ser Phe Val Ile Gly
        3875                3880                3885            
Ile Asp Leu Arg Ser Gly Ala Met Thr Pro Asp His Trp Ile Lys Arg
    3890                3895                3900                
Gly Thr Ala Leu Leu Met Ser Leu Asp Ser
3905                3910                


<210> 7970
<211> 1734
<212> PRT
<213> Homo sapiens

<400> 7970
Asp Pro Trp Cys Gly Ala Ile Gly Gly Gly Ser Asp Glu Trp Gln Pro
 1               5                  10                  15      
His Gly Pro Thr Gly Ala Val Arg Gly Pro Arg Gly Gly Ala Arg Ala
            20                  25                  30          
Gly Ala Arg Arg Arg Arg Gly Gly Trp Ala Gly Gly Gly Gly Gly Thr
        35                  40                  45              
Arg Arg Ala Leu Gly Val Pro Val Ala Arg Arg Arg Arg Met Trp Arg
    50                  55                  60                  
Ala Glu Gly Lys Trp Leu Pro Lys Thr Ser Arg Lys Ser Val Ser Gln
65                  70                  75                  80  
Ser Val Phe Cys Gly Thr Ser Thr Tyr Cys Val Leu Asn Thr Val Pro
                85                  90                  95      
Pro Ile Glu Asp Asp His Gly Asn Ser Asn Ser Ser His Val Lys Ile
            100                 105                 110         
Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Lys Cys Ser Ser Leu
        115                 120                 125             
Pro Lys Glu Arg His Arg Trp Asn Thr Asn Glu Glu Ile Ala Ala Tyr
    130                 135                 140                 
Leu Ile Thr Phe Glu Lys His Glu Glu Trp Leu Thr Thr Ser Pro Lys
145                 150                 155                 160 
Thr Arg Pro Gln Asn Gly Ser Met Ile Leu Tyr Asn Arg Lys Lys Val
                165                 170                 175     
Lys Tyr Arg Lys Asp Gly Tyr Cys Trp Lys Lys Arg Lys Asp Gly Lys
            180                 185                 190         
Thr Thr Arg Glu Asp His Met Lys Leu Lys Val Gln Gly Val Glu Cys
        195                 200                 205             
Leu Tyr Gly Cys Tyr Val His Ser Ser Ile Ile Pro Thr Phe His Arg
    210                 215                 220                 
Arg Cys Tyr Trp Leu Leu Gln Asn Pro Asp Ile Val Leu Val His Tyr
225                 230                 235                 240 
Leu Asn Val Pro Ala Ile Glu Asp Cys Gly Lys Pro Cys Gly Pro Ile
                245                 250                 255     
Leu Cys Ser Ile Asn Thr Asp Lys Lys Glu Trp Ala Lys Trp Thr Lys
            260                 265                 270         
Glu Glu Leu Ile Gly Gln Leu Lys Pro Met Phe His Gly Ile Lys Trp
        275                 280                 285             
Thr Cys Ser Asn Gly Asn Ser Ser Ser Gly Phe Ser Val Glu Gln Leu
    290                 295                 300                 
Val Gln Gln Ile Leu Asp Ser His Gln Thr Lys Pro Gln Pro Arg Thr
305                 310                 315                 320 
His Asn Cys Leu Cys Thr Gly Ser Leu Gly Ala Gly Gly Ser Val His
                325                 330                 335     
His Lys Cys Asn Ser Ala Lys His Arg Ile Ile Ser Pro Lys Val Glu
            340                 345                 350         
Pro Arg Thr Gly Gly Tyr Gly Ser His Ser Glu Val Gln His Asn Asp
        355                 360                 365             
Val Ser Glu Gly Lys His Glu His Ser His Ser Lys Gly Ser Ser Arg
    370                 375                 380                 
Glu Lys Arg Asn Gly Lys Val Ala Lys Pro Val Leu Leu His Gln Ser
385                 390                 395                 400 
Ser Thr Glu Val Ser Ser Thr Asn Gln Val Glu Val Pro Asp Thr Thr
                405                 410                 415     
Gln Ser Ser Pro Val Ser Ile Ser Ser Gly Leu Asn Ser Asp Pro Asp
            420                 425                 430         
Met Val Asp Ser Pro Val Val Thr Gly Val Ser Gly Met Ala Val Ala
        435                 440                 445             
Ser Val Met Gly Ser Leu Ser Gln Ser Ala Thr Val Phe Met Ser Glu
    450                 455                 460                 
Val Thr Asn Glu Ala Val Tyr Thr Met Ser Pro Thr Ala Gly Pro Asn
465                 470                 475                 480 
His His Leu Leu Ser Pro Asp Ala Ser Gln Gly Leu Val Leu Ala Val
                485                 490                 495     
Ser Ser Asp Gly His Lys Phe Ala Phe Pro Thr Thr Gly Ser Ser Glu
            500                 505                 510         
Ser Leu Ser Met Leu Pro Thr Asn Val Ser Glu Glu Leu Val Leu Ser
        515                 520                 525             
Thr Thr Leu Asp Gly Gly Arg Lys Ile Pro Glu Thr Thr Met Asn Phe
    530                 535                 540                 
Asp Pro Asp Cys Phe Leu Asn Asn Pro Lys Gln Gly Gln Thr Tyr Gly
545                 550                 555                 560 
Gly Gly Gly Leu Lys Ala Glu Met Val Ser Ser Asn Ile Arg His Ser
                565                 570                 575     
Pro Pro Gly Glu Arg Ser Phe Ser Phe Thr Thr Val Leu Thr Lys Glu
            580                 585                 590         
Ile Lys Thr Glu Asp Thr Ser Phe Glu Gln Gln Met Ala Lys Glu Ala
        595                 600                 605             
Tyr Ser Ser Ser Ala Ala Ala Val Ala Ala Ser Ser Leu Thr Leu Thr
    610                 615                 620                 
Ala Gly Ser Ser Leu Leu Pro Ser Gly Gly Gly Leu Ser Pro Ser Thr
625                 630                 635                 640 
Thr Leu Glu Gln Met Asp Phe Ser Ala Ile Asp Ser Asn Lys Asp Tyr
                645                 650                 655     
Thr Ser Ser Phe Ser Gln Thr Gly His Ser Pro His Ile His Gln Thr
            660                 665                 670         
Pro Ser Pro Ser Phe Phe Leu Gln Asp Ala Ser Lys Pro Leu Pro Val
        675                 680                 685             
Glu Gln Asn Thr His Ser Ser Leu Ser Asp Ser Gly Gly Thr Phe Val
    690                 695                 700                 
Met Pro Thr Val Lys Thr Glu Ala Ser Ser Gln Thr Ser Ser Cys Ser
705                 710                 715                 720 
Gly His Val Glu Thr Arg Ile Glu Ser Thr Ser Ser Leu His Leu Met
                725                 730                 735     
Gln Phe Gln Ala Asn Phe Gln Ala Met Thr Ala Glu Gly Glu Val Thr
            740                 745                 750         
Met Glu Thr Ser Gln Ala Ala Glu Gly Ser Glu Val Leu Leu Lys Ser
        755                 760                 765             
Gly Glu Leu Gln Ala Cys Ser Ser Glu His Tyr Leu Gln Pro Glu Thr
    770                 775                 780                 
Asn Gly Val Ile Arg Ser Ala Gly Gly Val Pro Ile Leu Pro Gly Asn
785                 790                 795                 800 
Val Val Gln Gly Leu Tyr Pro Val Ala Gln Pro Ser Leu Gly Asn Ala
                805                 810                 815     
Ser Asn Met Glu Leu Ser Leu Asp His Phe Asp Ile Ser Phe Ser Asn
            820                 825                 830         
Gln Phe Ser Asp Leu Ile Asn Asp Phe Ile Ser Val Glu Gly Gly Ser
        835                 840                 845             
Ser Thr Ile Tyr Gly His Gln Leu Val Ser Gly Asp Ser Thr Ala Leu
    850                 855                 860                 
Ser Gln Ser Glu Asp Gly Ala Arg Ala Pro Phe Thr Gln Ala Glu Met
865                 870                 875                 880 
Cys Leu Pro Cys Cys Ser Pro Gln Gln Gly Ser Leu Gln Leu Ser Ser
                885                 890                 895     
Ser Glu Gly Gly Ala Ser Thr Met Ala Tyr Met His Val Ala Glu Val
            900                 905                 910         
Val Ser Ala Ala Ser Ala Gln Gly Thr Leu Gly Met Leu Gln Gln Ser
        915                 920                 925             
Gly Arg Val Phe Met Val Thr Asp Tyr Ser Pro Glu Trp Ser Tyr Pro
    930                 935                 940                 
Glu Gly Gly Val Lys Val Leu Ile Thr Gly Pro Trp Gln Glu Ala Ser
945                 950                 955                 960 
Asn Asn Tyr Ser Cys Leu Phe Asp Gln Ile Ser Val Pro Ala Ser Leu
                965                 970                 975     
Ile Gln Pro Gly Val Leu Arg Cys Tyr Cys Pro Ala His Asp Thr Gly
            980                 985                 990         
Leu Val Thr Leu Gln Val Ala Phe Asn Asn Gln Ile Ile Ser Asn Ser
        995                 1000                1005            
Val Val Phe Glu Tyr Lys Ala Arg Ala Leu Pro Thr Leu Pro Ser Ser
    1010                1015                1020                
Gln His Asp Trp Leu Ser Leu Asp Asp Asn Gln Phe Arg Met Ser Ile
1025                1030                1035                1040
Leu Glu Arg Leu Glu Gln Met Glu Arg Arg Met Ala Glu Met Thr Gly
                1045                1050                1055    
Ser Gln Gln His Lys Gln Ala Ser Gly Gly Gly Ser Ser Gly Gly Gly
            1060                1065                1070        
Ser Gly Ser Gly Asn Gly Gly Ser Gln Ala Gln Cys Ala Ser Gly Thr
        1075                1080                1085            
Gly Ala Leu Gly Ser Cys Phe Glu Ser Arg Val Val Val Val Cys Glu
    1090                1095                1100                
Lys Met Met Ser Arg Ala Cys Trp Ala Lys Ser Lys His Leu Ile His
1105                1110                1115                1120
Ser Lys Thr Phe Arg Gly Met Thr Leu Leu His Leu Ala Ala Ala Gln
                1125                1130                1135    
Gly Tyr Ala Thr Leu Ile Gln Thr Leu Ile Lys Trp Arg Thr Lys His
            1140                1145                1150        
Ala Asp Ser Ile Asp Leu Glu Leu Glu Val Asp Pro Leu Asn Val Asp
        1155                1160                1165            
His Phe Ser Cys Thr Pro Leu Met Trp Ala Cys Ala Leu Gly His Leu
    1170                1175                1180                
Glu Ala Ala Val Val Leu Tyr Lys Trp Asp Arg Arg Ala Ile Ser Ile
1185                1190                1195                1200
Pro Asp Ser Leu Gly Arg Leu Pro Leu Gly Ile Ala Arg Ser Arg Gly
                1205                1210                1215    
His Val Lys Leu Ala Glu Cys Leu Glu His Leu Gln Arg Asp Glu Gln
            1220                1225                1230        
Ala Gln Leu Gly Gln Asn Pro Arg Ile His Cys Pro Ala Ser Glu Glu
        1235                1240                1245            
Pro Ser Thr Glu Ser Trp Met Ala Gln Trp His Ser Glu Ala Ile Ser
    1250                1255                1260                
Ser Pro Glu Ile Pro Lys Gly Val Thr Val Ile Ala Ser Thr Asn Pro
1265                1270                1275                1280
Glu Leu Arg Arg Pro Arg Ser Glu Pro Ser Asn Tyr Tyr Ser Ser Glu
                1285                1290                1295    
Ser His Lys Asp Tyr Pro Ala Pro Lys Lys His Lys Leu Asn Pro Glu
            1300                1305                1310        
Tyr Phe Gln Thr Arg Gln Glu Lys Leu Leu Pro Thr Ala Leu Ser Leu
        1315                1320                1325            
Glu Glu Pro Asn Ile Arg Lys Gln Ser Pro Ser Ser Lys Gln Ser Val
    1330                1335                1340                
Pro Glu Thr Leu Ser Pro Ser Glu Gly Val Arg Asp Phe Ser Arg Glu
1345                1350                1355                1360
Leu Ser Pro Pro Thr Pro Glu Thr Ala Ala Phe Gln Ala Ser Gly Ser
                1365                1370                1375    
Gln Pro Val Gly Lys Trp Asn Ser Lys Asp Leu Tyr Ile Gly Val Ser
            1380                1385                1390        
Thr Val Gln Val Thr Gly Asn Pro Lys Gly Thr Ser Val Gly Lys Glu
        1395                1400                1405            
Ala Ala Pro Ser Gln Val Arg Pro Arg Glu Pro Met Ser Val Leu Met
    1410                1415                1420                
Met Ala Asn Arg Glu Val Val Asn Thr Glu Leu Gly Ser Tyr Arg Asp
1425                1430                1435                1440
Ser Ala Glu Asn Glu Glu Cys Gly Gln Pro Met Asp Asp Ile Gln Val
                1445                1450                1455    
Asn Met Met Thr Leu Ala Glu His Ile Ile Glu Ala Thr Pro Asp Arg
            1460                1465                1470        
Ile Lys Gln Glu Asn Phe Val Pro Met Glu Ser Ser Gly Leu Glu Arg
        1475                1480                1485            
Thr Asp Pro Ala Thr Ile Ser Ser Thr Met Ser Trp Leu Ala Ser Tyr
    1490                1495                1500                
Leu Ala Asp Ala Asp Cys Leu Pro Ser Ala Ala Gln Ile Arg Ser Ala
1505                1510                1515                1520
Tyr Asn Glu Pro Leu Thr Pro Ser Ser Asn Thr Ser Leu Ser Pro Val
                1525                1530                1535    
Gly Ser Pro Val Ser Glu Ile Ala Phe Glu Lys Pro Asn Leu Pro Ser
            1540                1545                1550        
Ala Ala Asp Trp Ser Glu Phe Leu Ser Ala Ser Thr Ser Glu Lys Val
        1555                1560                1565            
Glu Asn Glu Phe Ala Gln Leu Thr Leu Ser Asp His Glu Gln Arg Glu
    1570                1575                1580                
Leu Tyr Glu Ala Ala Arg Leu Val Gln Thr Ala Phe Arg Lys Tyr Lys
1585                1590                1595                1600
Gly Arg Pro Leu Arg Glu Gln Gln Glu Val Ala Ala Ala Val Ile Gln
                1605                1610                1615    
Arg Cys Tyr Arg Lys Tyr Lys Gln Tyr Ala Leu Tyr Lys Lys Met Thr
            1620                1625                1630        
Gln Ala Ala Ile Leu Ile Gln Ser Lys Phe Arg Ser Tyr Tyr Glu Gln
        1635                1640                1645            
Lys Lys Phe Gln Gln Ser Arg Arg Ala Ala Val Leu Ile Gln Lys Tyr
    1650                1655                1660                
Tyr Arg Ser Tyr Lys Lys Cys Gly Lys Arg Arg Gln Ala Arg Arg Thr
1665                1670                1675                1680
Ala Val Ile Val Gln Gln Lys Leu Arg Ser Ser Leu Leu Thr Lys Lys
                1685                1690                1695    
Gln Asp Gln Ala Ala Arg Lys Ile Met Arg Phe Leu Arg Arg Cys Arg
            1700                1705                1710        
His Ser Pro Leu Val Asp His Arg Leu Tyr Lys Arg Ser Glu Arg Ile
        1715                1720                1725            
Glu Lys Gly Gln Gly Thr
    1730                


<210> 7971
<211> 1856
<212> PRT
<213> Homo sapiens

<400> 7971
Leu Asp Phe Asn Lys Lys Asn Leu Ser Phe Leu Gly Phe Pro Arg Gln
 1               5                  10                  15      
Arg Lys Val Ser Ser Phe Gln Lys Glu Phe Ser Leu Glu Asp Lys Glu
            20                  25                  30          
Gln Leu Ala Asn His Glu Arg Gly Ile Asp Ala Gln Leu Leu Val Ala
        35                  40                  45              
Leu Pro Lys Val Ala Glu Leu Arg Gln Ile Phe Glu Pro Lys Lys Lys
    50                  55                  60                  
Glu Phe Leu Glu Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu
65                  70                  75                  80  
Gly Ile Glu Asn Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly
                85                  90                  95      
Leu Val Thr His Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg
            100                 105                 110         
Ala Ser Asp Pro Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu
        115                 120                 125             
Glu Thr Ser Asp Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys
    130                 135                 140                 
Thr Glu Thr Ser Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr
145                 150                 155                 160 
Met Asp Thr His Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr
                165                 170                 175     
Lys Ala Glu Arg Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu
            180                 185                 190         
Asp Pro Glu Ala Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg
        195                 200                 205             
Lys Glu Pro Asp Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln
    210                 215                 220                 
Glu Glu Ser Ser Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr
225                 230                 235                 240 
Met Gly Leu Arg Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His
                245                 250                 255     
Val Gly Asp Gly Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn
            260                 265                 270         
Gln Arg Arg Gly Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu
        275                 280                 285             
Ser Pro Ala Ala Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp
    290                 295                 300                 
Ser Ser Phe Thr Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser
305                 310                 315                 320 
Ser Leu Gln Gln Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln
                325                 330                 335     
Leu Ser Pro Glu Ala Arg Pro Arg Cys Thr Ser His Ser Glu Thr Pro
            340                 345                 350         
Thr Val Asp Asp Glu Glu Lys Val Asp Glu Arg Ala Lys Leu Ser Val
        355                 360                 365             
Ala Ala Lys Arg Leu Leu Phe Arg Glu Met Glu Lys Ser Phe Asp Glu
    370                 375                 380                 
Gln Asn Val Pro Lys Arg Arg Ser Arg Asn Thr Ala Val Glu Gln Arg
385                 390                 395                 400 
Leu Arg Arg Leu Gln Asp Arg Ser Leu Thr Gln Pro Ile Thr Thr Glu
                405                 410                 415     
Glu Val Val Ile Ala Ala Thr Leu Gln Ala Ser Ala His Gln Lys Ala
            420                 425                 430         
Leu Ala Lys Asp Gln Thr Asn Glu Gly Lys Glu Leu Ala Glu Gln Gly
        435                 440                 445             
Glu Pro Asp Ser Ser Thr Leu Ser Leu Ala Glu Lys Leu Ala Leu Phe
    450                 455                 460                 
Asn Lys Leu Ser Gln Pro Val Ser Lys Ala Ile Ser Thr Arg Asn Arg
465                 470                 475                 480 
Ile Asp Thr Arg Gln Arg Arg Met Asn Ala Arg Tyr Gln Thr Gln Pro
                485                 490                 495     
Val Thr Leu Gly Glu Val Glu Gln Val Gln Ser Gly Lys Leu Ile Pro
            500                 505                 510         
Phe Ser Pro Ala Val Asn Thr Ser Val Ser Thr Val Ala Ser Thr Val
        515                 520                 525             
Ala Pro Met Tyr Ala Gly Asp Leu Arg Thr Lys Pro Pro Leu Asp His
    530                 535                 540                 
Asn Ala Ser Ala Thr Asp Tyr Lys Phe Ser Ser Ser Ile Glu Asn Ser
545                 550                 555                 560 
Asp Ser Pro Val Arg Ser Ile Leu Lys Ser Gln Ala Trp Gln Pro Leu
                565                 570                 575     
Val Glu Gly Ser Glu Asn Lys Gly Met Leu Arg Glu Tyr Gly Glu Thr
            580                 585                 590         
Glu Ser Lys Arg Ala Leu Thr Gly Arg Asp Ser Gly Met Glu Lys Tyr
        595                 600                 605             
Gly Ser Phe Glu Glu Ala Glu Ala Ser Tyr Pro Ile Leu Asn Arg Ala
    610                 615                 620                 
Arg Glu Gly Asp Ser His Lys Glu Ser Lys Tyr Ala Val Pro Arg Arg
625                 630                 635                 640 
Gly Ser Leu Glu Arg Ala Asn Pro Pro Ile Thr His Leu Gly Asp Glu
                645                 650                 655     
Pro Lys Glu Phe Ser Met Ala Lys Met Asn Ala Gln Gly Asn Leu Asp
            660                 665                 670         
Leu Arg Asp Arg Leu Pro Phe Glu Glu Lys Val Glu Val Glu Asn Val
        675                 680                 685             
Met Lys Arg Lys Phe Ser Leu Arg Ala Ala Glu Phe Gly Glu Pro Thr
    690                 695                 700                 
Ser Glu Gln Thr Gly Thr Ala Ala Gly Lys Thr Ile Ala Gln Thr Thr
705                 710                 715                 720 
Ala Pro Val Ser Trp Lys Pro Gln Asp Ser Ser Glu Gln Pro Gln Glu
                725                 730                 735     
Lys Leu Cys Lys Asn Pro Cys Ala Met Phe Ala Ala Gly Glu Ile Lys
            740                 745                 750         
Thr Pro Thr Gly Glu Gly Leu Leu Asp Ser Pro Ser Lys Thr Met Ser
        755                 760                 765             
Ile Lys Glu Arg Leu Ala Leu Leu Lys Lys Ser Gly Glu Glu Asp Trp
    770                 775                 780                 
Arg Asn Arg Leu Ser Arg Arg Gln Glu Gly Gly Lys Ala Pro Ala Ser
785                 790                 795                 800 
Ser Leu His Thr Gln Glu Ala Gly Arg Ser Leu Ile Lys Lys Arg Val
                805                 810                 815     
Thr Glu Ser Arg Glu Ser Gln Met Thr Ile Glu Glu Arg Lys Gln Leu
            820                 825                 830         
Ile Thr Val Arg Glu Glu Ala Trp Lys Thr Arg Gly Arg Gly Ala Ala
        835                 840                 845             
Asn Asp Ser Thr Gln Phe Thr Val Ala Gly Arg Met Val Lys Lys Gly
    850                 855                 860                 
Leu Ala Ser Pro Thr Ala Ile Thr Pro Val Ala Ser Pro Ile Cys Gly
865                 870                 875                 880 
Lys Thr Arg Gly Thr Thr Pro Val Ser Lys Pro Leu Glu Asp Ile Glu
                885                 890                 895     
Ala Arg Pro Asp Met Gln Leu Glu Ser Asp Leu Lys Leu Asp Arg Leu
            900                 905                 910         
Glu Thr Phe Leu Arg Arg Leu Asn Asn Lys Val Gly Gly Met His Glu
        915                 920                 925             
Thr Val Leu Thr Val Thr Gly Lys Ser Val Lys Glu Val Met Lys Pro
    930                 935                 940                 
Asp Asp Asp Glu Thr Phe Ala Lys Phe Tyr Arg Ser Val Asp Tyr Asn
945                 950                 955                 960 
Met Pro Arg Ser Pro Val Glu Met Asp Glu Asp Phe Asp Val Ile Phe
                965                 970                 975     
Asp Pro Tyr Ala Pro Lys Leu Thr Ser Ser Val Ala Glu His Lys Arg
            980                 985                 990         
Ala Val Arg Pro Lys Arg Arg Val Gln Ala Ser Lys Asn Pro Leu Lys
        995                 1000                1005            
Met Leu Ala Ala Arg Glu Asp Leu Leu Gln Glu Tyr Thr Glu Gln Arg
    1010                1015                1020                
Leu Asn Val Ala Phe Met Glu Ser Lys Arg Met Lys Val Glu Lys Met
1025                1030                1035                1040
Ser Ser Asn Ser Asn Phe Ser Glu Val Thr Leu Ala Gly Leu Ala Ser
                1045                1050                1055    
Lys Glu Asn Phe Ser Asn Val Ser Leu Arg Ser Val Asn Leu Thr Glu
            1060                1065                1070        
Gln Asn Ser Asn Asn Ser Ala Val Pro Tyr Lys Arg Leu Met Leu Leu
        1075                1080                1085            
Gln Ile Lys Gly Arg Arg His Val Gln Thr Arg Leu Val Glu Pro Arg
    1090                1095                1100                
Ala Ser Ala Leu Asn Ser Gly Asp Cys Phe Leu Leu Leu Ser Pro His
1105                1110                1115                1120
Cys Cys Phe Leu Trp Val Gly Glu Phe Ala Asn Val Ile Glu Lys Ala
                1125                1130                1135    
Lys Ala Ser Glu Leu Ala Thr Leu Ile Gln Thr Lys Arg Glu Leu Gly
            1140                1145                1150        
Cys Arg Ala Thr Tyr Ile Gln Thr Ile Glu Glu Gly Ile Asn Thr His
        1155                1160                1165            
Thr His Ala Ala Lys Asp Phe Trp Lys Leu Leu Gly Gly Gln Thr Ser
    1170                1175                1180                
Tyr Gln Ser Ala Gly Asp Pro Lys Glu Asp Glu Leu Tyr Glu Ala Ala
1185                1190                1195                1200
Ile Ile Glu Thr Asn Cys Ile Tyr Arg Leu Met Asp Asp Lys Leu Val
                1205                1210                1215    
Pro Asp Asp Asp Tyr Trp Gly Lys Ile Pro Lys Cys Ser Leu Leu Gln
            1220                1225                1230        
Pro Lys Glu Val Leu Val Phe Asp Phe Gly Ser Glu Val Tyr Val Trp
        1235                1240                1245            
His Gly Lys Glu Val Thr Leu Ala Gln Arg Lys Ile Ala Phe Gln Leu
    1250                1255                1260                
Ala Lys His Leu Trp Asn Gly Thr Phe Asp Tyr Glu Asn Cys Asp Ile
1265                1270                1275                1280
Asn Pro Leu Asp Pro Gly Glu Cys Asn Pro Leu Ile Pro Arg Lys Gly
                1285                1290                1295    
Gln Gly Arg Pro Asp Trp Ala Ile Phe Gly Arg Leu Thr Glu His Asn
            1300                1305                1310        
Glu Thr Ile Leu Phe Lys Glu Lys Phe Leu Asp Trp Thr Glu Leu Lys
        1315                1320                1325            
Arg Ser Asn Glu Lys Asn Pro Gly Glu Leu Ala Gln His Lys Glu Asp
    1330                1335                1340                
Pro Arg Thr Asp Val Lys Ala Tyr Asp Val Thr Arg Met Val Ser Met
1345                1350                1355                1360
Pro Gln Thr Thr Ala Gly Thr Ile Leu Asp Gly Val Asn Val Gly Arg
                1365                1370                1375    
Gly Tyr Gly Leu Val Glu Gly His Asp Arg Arg Gln Phe Glu Ile Thr
            1380                1385                1390        
Ser Val Ser Val Asp Val Trp His Ile Leu Glu Phe Asp Tyr Ser Arg
        1395                1400                1405            
Leu Pro Lys Gln Ser Ile Gly Gln Phe His Glu Gly Asp Ala Tyr Val
    1410                1415                1420                
Val Lys Trp Lys Phe Met Val Ser Thr Ala Val Gly Ser Arg Gln Lys
1425                1430                1435                1440
Gly Glu His Ser Val Arg Ala Ala Gly Lys Glu Lys Cys Val Tyr Phe
                1445                1450                1455    
Phe Trp Gln Gly Arg His Ser Thr Val Ser Glu Lys Gly Thr Ser Ala
            1460                1465                1470        
Leu Met Thr Val Glu Leu Asp Glu Glu Arg Gly Ala Gln Val Gln Val
        1475                1480                1485            
Leu Gln Gly Lys Glu Pro Pro Cys Phe Leu Gln Cys Phe Gln Gly Gly
    1490                1495                1500                
Met Val Val His Ser Gly Arg Arg Glu Glu Glu Glu Glu Asn Val Gln
1505                1510                1515                1520
Ser Glu Trp Arg Leu Tyr Cys Val Arg Gly Glu Val Pro Val Glu Gly
                1525                1530                1535    
Asn Leu Leu Glu Val Ala Cys His Cys Ser Ser Leu Arg Ser Arg Thr
            1540                1545                1550        
Ser Met Val Val Leu Asn Val Asn Lys Ala Leu Ile Tyr Leu Trp His
        1555                1560                1565            
Gly Cys Lys Ala Gln Ala His Thr Lys Glu Val Gly Arg Thr Ala Ala
    1570                1575                1580                
Asn Lys Ile Lys Glu Gln Cys Pro Leu Glu Ala Gly Leu His Ser Ser
1585                1590                1595                1600
Ser Lys Val Thr Ile His Glu Cys Asp Glu Gly Ser Glu Pro Leu Gly
                1605                1610                1615    
Phe Trp Asp Ala Leu Gly Arg Arg Asp Arg Lys Ala Tyr Asp Cys Met
            1620                1625                1630        
Leu Gln Asp Pro Gly Ser Phe Asn Phe Ala Pro Arg Leu Phe Ile Leu
        1635                1640                1645            
Ser Ser Ser Ser Gly Asp Phe Ala Ala Thr Glu Phe Val Tyr Pro Ala
    1650                1655                1660                
Arg Ala Pro Ser Val Val Ser Ser Met Pro Phe Leu Gln Glu Asp Leu
1665                1670                1675                1680
Tyr Ser Ala Pro Gln Pro Ala Leu Phe Leu Val Asp Asn His His Glu
                1685                1690                1695    
Val Tyr Leu Trp Gln Gly Trp Trp Pro Ile Glu Asn Lys Ile Thr Gly
            1700                1705                1710        
Ser Ala Arg Ile Arg Trp Ala Ser Asp Arg Lys Ser Ala Met Glu Thr
        1715                1720                1725            
Val Leu Gln Tyr Cys Lys Gly Lys Asn Leu Lys Lys Pro Ala Pro Lys
    1730                1735                1740                
Ser Tyr Leu Ile His Ala Gly Leu Glu Pro Leu Thr Phe Thr Asn Met
1745                1750                1755                1760
Phe Pro Ser Trp Glu His Arg Glu Asp Ile Ala Glu Ile Thr Glu Met
                1765                1770                1775    
Asp Thr Glu Val Ser Asn Gln Ile Thr Leu Val Glu Asp Val Leu Ala
            1780                1785                1790        
Lys Leu Cys Lys Thr Ile Tyr Pro Leu Ala Asp Leu Leu Ala Arg Pro
        1795                1800                1805            
Leu Pro Glu Gly Val Asp Pro Leu Lys Leu Glu Ile Tyr Leu Thr Asp
    1810                1815                1820                
Glu Asp Phe Glu Phe Ala Leu Asp Met Thr Arg Asp Glu Tyr Asn Ala
1825                1830                1835                1840
Leu Pro Ala Trp Lys Gln Val Asn Leu Lys Lys Ala Lys Gly Leu Phe
                1845                1850                1855    


<210> 7972
<211> 929
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 411
<223> Xaa = Any Amino Acid

<400> 7972
Met Asn Arg Pro Glu Phe Tyr Glu Arg Val Leu Pro Val Ile Ser Leu
 1               5                  10                  15      
Met Ile Ser Ala Leu Arg Leu Ala Leu Leu Lys Lys Ser Gly Glu Glu
            20                  25                  30          
Asp Trp Arg Asn Arg Leu Ser Arg Arg Gln Glu Gly Ser Lys Ala Pro
        35                  40                  45              
Ala Ser Ser Leu Gln Gly Ser Pro Ser Ser Gly Arg Ile Val Leu Val
    50                  55                  60                  
Leu Gln Cys Pro Lys Pro Arg Val Thr Glu Ser Arg Glu Ser Gln Met
65                  70                  75                  80  
Met Ile Glu Glu Arg Lys Gln Leu Ile Thr Val Arg Glu Glu Ala Trp
                85                  90                  95      
Lys Thr Arg Gly Arg Gly Ala Ala Asn Asp Ser Thr Gln Phe Thr Val
            100                 105                 110         
Ala Gly Arg Met Val Lys Lys Gly Leu Ala Ser Pro Thr Ala Ile Thr
        115                 120                 125             
Pro Val Ala Ser Ala Ile Cys Gly Lys Thr Arg Gly Thr Thr Pro Val
    130                 135                 140                 
Ser Lys Pro Leu Glu Val Gly Gly Met His Glu Thr Val Leu Thr Val
145                 150                 155                 160 
Thr Gly Lys Ser Val Lys Glu Leu Met Lys Pro Asp Asp Asp Glu Thr
                165                 170                 175     
Phe Ala Gln Phe Tyr Arg Asn Val Asp Cys Asn Met Leu Arg Ser Pro
            180                 185                 190         
Val Glu Leu Asp Glu Asp Phe Asp Val Ile Phe Asp Pro Tyr Ala Pro
        195                 200                 205             
Lys Leu Thr Ser Ser Val Ala Glu His Lys Trp Ala Val Arg Pro Lys
    210                 215                 220                 
Arg Gln Val Gln Ala Ser Lys Asn Pro Leu Lys Met Leu Ala Ala Arg
225                 230                 235                 240 
Glu Asp Leu Leu Gln Glu Tyr Thr Glu Gln Arg Leu Asn Val Ala Phe
                245                 250                 255     
Met Glu Ser Lys Arg Ile Lys Val Glu Lys Arg Glu Tyr Leu Asn Pro
            260                 265                 270         
His Pro Ala Ser Val Phe Gly Asn Gly Phe Phe Arg Cys Phe Thr His
        275                 280                 285             
Cys Leu Val Phe Cys Leu Val Lys Ala Asn Asn Gly Ala Gln Lys Ala
    290                 295                 300                 
Leu Met Asn Phe Ser Glu Val Thr Leu Ala Gly Leu Ala Ser Lys Glu
305                 310                 315                 320 
Asn Phe Ser Asn Val Ser Leu Arg Ser Val Asn Leu Thr Glu Gln Asn
                325                 330                 335     
Ser Asn Asn Ser Ala Val Pro Phe Lys Arg Leu Met Leu Leu Gln Ile
            340                 345                 350         
Lys Gly Arg Arg His Val Gln Thr Arg Leu Val Glu Pro Arg Ala Ser
        355                 360                 365             
Ala Leu Asn Ser Gly Asp Cys Phe Leu Leu Leu Ser Pro His Cys Cys
    370                 375                 380                 
Phe Leu Trp Val Gly Glu Phe Ala Asn Ala Ile Glu Lys Ala Lys Asn
385                 390                 395                 400 
Leu Gln Leu Asp Cys Arg Ala Thr Tyr Ile Xaa Ile Ile Glu Glu Gly
                405                 410                 415     
Ile Asn Ile His Thr Leu Ala Ala Lys Asp Phe Cys Lys Leu Leu Gly
            420                 425                 430         
Gly Gln Thr Ser Tyr Gln Ser Ala Gly Asp Pro Lys Glu Asp Glu Leu
        435                 440                 445             
Tyr Glu Ala Ala Ile Ile Glu Thr Asn Cys Ile Tyr Cys Leu Met Asp
    450                 455                 460                 
Asp Lys Leu Val Pro Asp Asp Asp Tyr Trp Gly Lys Ile Pro Lys Cys
465                 470                 475                 480 
Ser Leu Leu Gln Pro Lys Glu Val Leu Val Phe Asp Phe Gly Ser Glu
                485                 490                 495     
Val Tyr Val Trp His Gly Lys Glu Val Thr Leu Ala Gln Arg Lys Ile
            500                 505                 510         
Glu Phe Gln Leu Ala Lys His Leu Trp Asn Gly Thr Phe Asp Tyr Glu
        515                 520                 525             
Asn Cys Asp Ile Asn Pro Leu Asp Pro Gly Glu Cys Asn Pro Leu Ile
    530                 535                 540                 
Arg Arg Lys Gly Gln Gly Arg Pro Asp Trp Ala Ile Phe Gly Arg Leu
545                 550                 555                 560 
Thr Glu His Asn Glu Thr Ile Leu Phe Lys Glu Lys Phe Leu Asp Trp
                565                 570                 575     
Thr Glu Leu Lys Arg Pro Asn Glu Lys Asn Pro Gly Glu Leu Ala Gln
            580                 585                 590         
His Lys Glu Asp Ser Arg Ala Asp Val Lys Arg Asn Asn Val Thr Arg
        595                 600                 605             
Met Val Ser Val Pro Gln Thr Thr Ala Gly Ala Ile Leu Asp Arg Val
    610                 615                 620                 
Asn Ile Gly Cys Gly Cys Gly Leu Val Glu Gly His His Arg Arg Gln
625                 630                 635                 640 
Phe Glu Ile Thr Ser Val Ser Val Asp Val Trp Tyr Ile Leu Glu Phe
                645                 650                 655     
Asp Tyr Ser Arg Leu Pro Lys Gln Ser Ile Gly Gln Phe His Glu Gly
            660                 665                 670         
Asp Ala Tyr Val Val Lys Trp Lys Phe Met Val Ser Thr Ala Asp Pro
        675                 680                 685             
Gly Ser Phe Asn Phe Ala Pro Arg Leu Phe Val Leu Ser Ser Ser Ser
    690                 695                 700                 
Gly Asp Phe Ala Ala Thr Glu Phe Val Tyr Pro Ala Arg Ala Pro Ser
705                 710                 715                 720 
Val Val Ser Ser Met Pro Phe Leu Gln Glu Asp Leu Tyr Ser Val Pro
                725                 730                 735     
Gln Pro Val Pro Phe Leu Asp Asn His His Glu Val Cys Leu Trp Gln
            740                 745                 750         
Gly Trp Trp Pro Ile Glu Asn Lys Ile Thr Gly Ser Ala Arg Ile Cys
        755                 760                 765             
Arg Ala Ser Asp Gln Lys Ser Thr Met Glu Thr Met Leu Gln Tyr Cys
    770                 775                 780                 
Lys Asp Glu Ala Ser Pro Ala Ala Pro Arg Ser Pro Arg Pro Phe Phe
785                 790                 795                 800 
Pro Phe Cys Met Gly Gln Pro Glu Lys Asn Leu Lys Lys Pro Val Pro
                805                 810                 815     
Lys Ser Tyr Leu Ile His Ala Gly Leu Glu Pro Leu Thr Phe Thr Asn
            820                 825                 830         
Met Phe Pro Ser Trp Glu His Arg Asp Asp Thr Ala Glu Ile Thr Glu
        835                 840                 845             
Met Asp Met Glu Val Ser Asn Gln Ile Thr Leu Val Glu Asp Val Leu
    850                 855                 860                 
Ala Lys Leu Cys Lys Thr Ile Tyr Leu Leu Ala Asn Leu Leu Ala Arg
865                 870                 875                 880 
Pro Leu Pro Glu Gly Val Asp Pro Leu Lys Leu Glu Ile Tyr Leu Thr
                885                 890                 895     
Asp Glu Asp Phe Glu Phe Ala Leu Asp Met Met Arg Asp Glu Tyr Asn
            900                 905                 910         
Ala Leu Pro Ala Trp Lys Gln Val Asn Leu Lys Lys Ala Lys Gly Leu
        915                 920                 925             
Phe
    


<210> 7973
<211> 2282
<212> PRT
<213> Homo sapiens

<400> 7973
Leu Asp Phe Asn Lys Lys Asn Leu Ser Phe Leu Gly Phe Pro Arg Gln
 1               5                  10                  15      
Arg Lys Val Ser Ser Phe Gln Lys Glu Phe Ser Leu Glu Asp Lys Glu
            20                  25                  30          
Gln Leu Ala Asn His Glu Arg Gly Ile Asp Ala Gln Leu Leu Val Ala
        35                  40                  45              
Leu Pro Lys Val Ala Glu Leu Arg Gln Ile Phe Glu Pro Lys Lys Lys
    50                  55                  60                  
Glu Phe Leu Glu Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu
65                  70                  75                  80  
Gly Ile Glu Asn Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly
                85                  90                  95      
Leu Val Thr His Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg
            100                 105                 110         
Ala Ser Asp Pro Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu
        115                 120                 125             
Glu Thr Ser Asp Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys
    130                 135                 140                 
Thr Glu Thr Ser Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr
145                 150                 155                 160 
Met Asp Thr His Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr
                165                 170                 175     
Lys Ala Glu Arg Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu
            180                 185                 190         
Asp Pro Glu Ala Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg
        195                 200                 205             
Lys Glu Pro Asp Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln
    210                 215                 220                 
Glu Glu Ser Ser Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr
225                 230                 235                 240 
Met Gly Leu Arg Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His
                245                 250                 255     
Val Gly Asp Gly Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn
            260                 265                 270         
Gln Arg Arg Gly Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu
        275                 280                 285             
Ser Pro Ala Ala Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp
    290                 295                 300                 
Ser Ser Phe Thr Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser
305                 310                 315                 320 
Ser Leu Gln Gln Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln
                325                 330                 335     
Leu Ser Pro Glu Ala Arg Pro Ser Thr Gly Lys Pro Lys His Glu Trp
            340                 345                 350         
Phe Leu Gln Lys Asp Ser Glu Gly Asp Thr Pro Ser Leu Ile Asn Trp
        355                 360                 365             
Pro Ser Arg Val Lys Val Arg Glu Lys Leu Val Lys Glu Glu Ser Ala
    370                 375                 380                 
Arg Asn Ser Pro Glu Leu Ala Ser Glu Ser Val Thr Gln Arg Arg His
385                 390                 395                 400 
Gln Pro Ala Pro Val His Tyr Val Ser Phe Gln Ser Glu His Ser Ala
                405                 410                 415     
Phe Asp Arg Val Pro Ser Lys Ala Ala Gly Ser Thr Arg Gln Pro Ile
            420                 425                 430         
Arg Gly Tyr Val Gln Pro Ala Asp Thr Gly His Thr Ala Lys Leu Val
        435                 440                 445             
Thr Pro Glu Thr Pro Glu Asn Ala Ser Glu Cys Ser Trp Val Ala Ser
    450                 455                 460                 
Ala Thr Gln Asn Val Pro Lys Pro Pro Ser Leu Thr Val Leu Glu Gly
465                 470                 475                 480 
Asp Gly Arg Asp Ser Pro Val Leu His Val Cys Glu Ser Lys Ala Glu
                485                 490                 495     
Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Lys Glu Glu Asp Val Cys
            500                 505                 510         
Phe Thr Glu Ala Leu Glu Gln Ser Lys Lys Thr Leu Leu Ala Leu Glu
        515                 520                 525             
Gly Asp Gly Leu Val Arg Ser Pro Glu Asp Pro Ser Arg Asn Glu Asp
    530                 535                 540                 
Phe Gly Lys Pro Ala Val Ser Thr Val Thr Leu Glu His Gln Lys Glu
545                 550                 555                 560 
Leu Glu Asn Val Ala Gln Pro Pro Gln Ala Pro His Gln Pro Thr Glu
                565                 570                 575     
Arg Thr Gly Arg Ser Glu Met Val Leu Tyr Ile Gln Ser Glu Pro Val
            580                 585                 590         
Ser Gln Asp Ala Lys Pro Thr Gly His Asn Arg Glu Ala Ser Lys Lys
        595                 600                 605             
Arg Lys Val Arg Thr Arg Ser Leu Ser Asp Phe Thr Gly Pro Pro Gln
    610                 615                 620                 
Leu Gln Ala Leu Lys Tyr Lys Asp Pro Ala Ser Arg Arg Glu Leu Glu
625                 630                 635                 640 
Leu Pro Ser Ser Lys Thr Glu Gly Pro Tyr Gly Glu Ile Ser Met Leu
                645                 650                 655     
Asp Thr Lys Val Ser Val Ala Gln Leu Arg Ser Ala Phe Leu Ala Ser
            660                 665                 670         
Ala Asn Ala Cys Arg Arg Pro Glu Leu Lys Ser Arg Val Glu Arg Ser
        675                 680                 685             
Ala Glu Gly Pro Gly Leu Pro Thr Gly Val Glu Arg Glu Arg Gly Ser
    690                 695                 700                 
Arg Lys Pro Arg Arg Tyr Phe Ser Pro Gly Glu Ser Arg Lys Thr Ser
705                 710                 715                 720 
Glu Arg Phe Arg Thr Gln Pro Ile Thr Ser Ala Glu Arg Lys Glu Ser
                725                 730                 735     
Asp Arg Cys Thr Ser His Ser Glu Thr Pro Thr Val Asp Asp Glu Glu
            740                 745                 750         
Lys Val Asp Glu Arg Ala Lys Leu Ser Val Ala Ala Lys Arg Leu Leu
        755                 760                 765             
Phe Arg Glu Met Glu Lys Ser Phe Asp Glu Gln Asn Val Pro Lys Arg
    770                 775                 780                 
Arg Ser Arg Asn Thr Ala Val Glu Gln Arg Leu Arg Arg Leu Gln Asp
785                 790                 795                 800 
Arg Ser Leu Thr Gln Pro Ile Thr Thr Glu Glu Val Val Ile Ala Ala
                805                 810                 815     
Thr Glu Pro Ile Pro Ala Ser Cys Ser Gly Gly Thr His Pro Val Met
            820                 825                 830         
Ala Arg Leu Pro Ser Pro Thr Val Ala Arg Ser Ala Val Gln Pro Ala
        835                 840                 845             
Arg Leu Gln Ala Ser Ala His Gln Lys Ala Leu Ala Lys Asp Gln Thr
    850                 855                 860                 
Asn Glu Gly Lys Glu Leu Ala Glu Gln Gly Glu Pro Asp Ser Ser Thr
865                 870                 875                 880 
Leu Ser Leu Ala Glu Lys Leu Ala Leu Phe Asn Lys Leu Ser Gln Pro
                885                 890                 895     
Val Ser Lys Ala Ile Ser Thr Arg Asn Arg Ile Asp Thr Arg Gln Arg
            900                 905                 910         
Arg Met Asn Ala Arg Tyr Gln Thr Gln Pro Val Thr Leu Gly Glu Val
        915                 920                 925             
Glu Gln Val Gln Ser Gly Lys Leu Ile Pro Phe Ser Pro Ala Val Asn
    930                 935                 940                 
Thr Ser Val Ser Thr Val Ala Ser Thr Val Ala Pro Met Tyr Ala Gly
945                 950                 955                 960 
Asp Leu Arg Thr Lys Pro Pro Leu Asp His Asn Ala Ser Ala Thr Asp
                965                 970                 975     
Tyr Lys Phe Ser Ser Ser Ile Glu Asn Ser Asp Ser Pro Val Arg Ser
            980                 985                 990         
Ile Leu Lys Ser Gln Ala Trp Gln Pro Leu Val Glu Gly Ser Glu Asn
        995                 1000                1005            
Lys Gly Met Leu Arg Glu Tyr Gly Glu Thr Glu Ser Lys Arg Ala Leu
    1010                1015                1020                
Thr Gly Arg Asp Ser Gly Met Glu Lys Tyr Gly Ser Phe Glu Glu Ala
1025                1030                1035                1040
Glu Ala Ser Tyr Pro Ile Leu Asn Arg Ala Arg Glu Gly Asp Ser His
                1045                1050                1055    
Lys Glu Ser Lys Tyr Ala Val Pro Arg Arg Gly Ser Leu Glu Arg Ala
            1060                1065                1070        
Asn Pro Pro Ile Thr His Leu Gly Asp Glu Pro Lys Glu Phe Ser Met
        1075                1080                1085            
Ala Lys Met Asn Ala Gln Gly Asn Leu Asp Leu Arg Asp Arg Leu Pro
    1090                1095                1100                
Phe Glu Glu Lys Val Glu Val Glu Asn Val Met Lys Arg Lys Phe Ser
1105                1110                1115                1120
Leu Arg Ala Ala Glu Phe Gly Glu Pro Thr Ser Glu Gln Thr Gly Thr
                1125                1130                1135    
Ala Ala Gly Lys Thr Ile Ala Gln Thr Thr Ala Pro Val Ser Trp Lys
            1140                1145                1150        
Pro Gln Asp Ser Ser Glu Gln Pro Gln Glu Lys Leu Cys Lys Asn Pro
        1155                1160                1165            
Cys Ala Met Phe Ala Ala Gly Glu Ile Lys Thr Pro Thr Gly Glu Gly
    1170                1175                1180                
Leu Leu Asp Ser Pro Ser Lys Thr Met Ser Ile Lys Glu Arg Leu Ala
1185                1190                1195                1200
Leu Leu Lys Lys Ser Gly Glu Glu Asp Trp Arg Asn Arg Leu Ser Arg
                1205                1210                1215    
Arg Gln Glu Gly Gly Lys Ala Pro Ala Ser Ser Leu His Thr Gln Glu
            1220                1225                1230        
Ala Gly Arg Ser Leu Ile Lys Lys Arg Val Thr Glu Ser Arg Glu Ser
        1235                1240                1245            
Gln Met Thr Ile Glu Glu Arg Lys Gln Leu Ile Thr Val Arg Glu Glu
    1250                1255                1260                
Ala Trp Lys Thr Arg Gly Arg Gly Ala Ala Asn Asp Ser Thr Gln Phe
1265                1270                1275                1280
Thr Val Ala Gly Arg Met Val Lys Lys Gly Leu Ala Ser Pro Thr Ala
                1285                1290                1295    
Ile Thr Pro Val Ala Ser Pro Ile Cys Gly Lys Thr Arg Gly Thr Thr
            1300                1305                1310        
Pro Val Ser Lys Pro Leu Glu Asp Ile Glu Ala Arg Pro Asp Met Gln
        1315                1320                1325            
Leu Glu Ser Asp Leu Lys Leu Asp Arg Leu Glu Thr Phe Leu Arg Arg
    1330                1335                1340                
Leu Asn Asn Lys Val Gly Gly Met His Glu Thr Val Leu Thr Val Thr
1345                1350                1355                1360
Gly Lys Ser Val Lys Glu Val Met Lys Pro Asp Asp Asp Glu Thr Phe
                1365                1370                1375    
Ala Lys Phe Tyr Arg Ser Val Asp Tyr Asn Met Pro Arg Ser Pro Val
            1380                1385                1390        
Glu Met Asp Glu Asp Phe Asp Val Ile Phe Asp Pro Tyr Ala Pro Lys
        1395                1400                1405            
Leu Thr Ser Ser Val Ala Glu His Lys Arg Ala Val Arg Pro Lys Arg
    1410                1415                1420                
Arg Val Gln Ala Ser Lys Asn Pro Leu Lys Met Leu Ala Ala Arg Glu
1425                1430                1435                1440
Asp Leu Leu Gln Glu Tyr Thr Glu Gln Arg Leu Asn Val Ala Phe Met
                1445                1450                1455    
Glu Ser Lys Arg Met Lys Val Glu Lys Met Ser Ser Asn Ser Asn Phe
            1460                1465                1470        
Ser Glu Val Thr Leu Ala Gly Leu Ala Ser Lys Glu Asn Phe Ser Asn
        1475                1480                1485            
Val Ser Leu Arg Ser Val Asn Leu Thr Glu Gln Asn Ser Asn Asn Ser
    1490                1495                1500                
Ala Val Pro Tyr Lys Arg Leu Met Leu Leu Gln Ile Lys Gly Arg Arg
1505                1510                1515                1520
His Val Gln Thr Arg Leu Val Glu Pro Arg Ala Ser Ala Leu Asn Ser
                1525                1530                1535    
Gly Asp Cys Phe Leu Leu Leu Ser Pro His Cys Cys Phe Leu Trp Val
            1540                1545                1550        
Gly Glu Phe Ala Asn Val Ile Glu Lys Ala Lys Ala Ser Glu Leu Ala
        1555                1560                1565            
Thr Leu Ile Gln Thr Lys Arg Glu Leu Gly Cys Arg Ala Thr Tyr Ile
    1570                1575                1580                
Gln Thr Ile Glu Glu Gly Ile Asn Thr His Thr His Ala Ala Lys Asp
1585                1590                1595                1600
Phe Trp Lys Leu Leu Gly Gly Gln Thr Ser Tyr Gln Ser Ala Gly Asp
                1605                1610                1615    
Pro Lys Glu Asp Glu Leu Tyr Glu Ala Ala Ile Ile Glu Thr Asn Cys
            1620                1625                1630        
Ile Tyr Arg Leu Met Asp Asp Lys Leu Val Pro Asp Asp Asp Tyr Trp
        1635                1640                1645            
Gly Lys Ile Pro Lys Cys Ser Leu Leu Gln Pro Lys Glu Val Leu Val
    1650                1655                1660                
Phe Asp Phe Gly Ser Glu Val Tyr Val Trp His Gly Lys Glu Val Thr
1665                1670                1675                1680
Leu Ala Gln Arg Lys Ile Ala Phe Gln Leu Ala Lys His Leu Trp Asn
                1685                1690                1695    
Gly Thr Phe Asp Tyr Glu Asn Cys Asp Ile Asn Pro Leu Asp Pro Gly
            1700                1705                1710        
Glu Cys Asn Pro Leu Ile Pro Arg Lys Gly Gln Gly Arg Pro Asp Trp
        1715                1720                1725            
Ala Ile Phe Gly Arg Leu Thr Glu His Asn Glu Thr Ile Leu Phe Lys
    1730                1735                1740                
Glu Lys Phe Leu Asp Trp Thr Glu Leu Lys Arg Ser Asn Glu Lys Asn
1745                1750                1755                1760
Pro Gly Glu Leu Ala Gln His Lys Glu Asp Pro Arg Thr Asp Val Lys
                1765                1770                1775    
Ala Tyr Asp Val Thr Arg Met Val Ser Met Pro Gln Thr Thr Ala Gly
            1780                1785                1790        
Thr Ile Leu Asp Gly Val Asn Val Gly Arg Gly Tyr Gly Leu Val Glu
        1795                1800                1805            
Gly His Asp Arg Arg Gln Phe Glu Ile Thr Ser Val Ser Val Asp Val
    1810                1815                1820                
Trp His Ile Leu Glu Phe Asp Tyr Ser Arg Leu Pro Lys Gln Ser Ile
1825                1830                1835                1840
Gly Gln Phe His Glu Gly Asp Ala Tyr Val Val Lys Trp Lys Phe Met
                1845                1850                1855    
Val Ser Thr Ala Val Gly Ser Arg Gln Lys Gly Glu His Ser Val Arg
            1860                1865                1870        
Ala Ala Gly Lys Glu Lys Cys Val Tyr Phe Phe Trp Gln Gly Arg His
        1875                1880                1885            
Ser Thr Val Ser Glu Lys Gly Thr Ser Ala Leu Met Thr Val Glu Leu
    1890                1895                1900                
Asp Glu Glu Arg Gly Ala Gln Val Gln Val Leu Gln Gly Lys Glu Pro
1905                1910                1915                1920
Pro Cys Phe Leu Gln Cys Phe Gln Gly Gly Met Val Val His Ser Gly
                1925                1930                1935    
Arg Arg Glu Glu Glu Glu Glu Asn Val Gln Ser Glu Trp Arg Leu Tyr
            1940                1945                1950        
Cys Val Arg Gly Glu Val Pro Val Glu Gly Asn Leu Leu Glu Val Ala
        1955                1960                1965            
Cys His Cys Ser Ser Leu Arg Ser Arg Thr Ser Met Val Val Leu Asn
    1970                1975                1980                
Val Asn Lys Ala Leu Ile Tyr Leu Trp His Gly Cys Lys Ala Gln Ala
1985                1990                1995                2000
His Thr Lys Glu Val Gly Arg Thr Ala Ala Asn Lys Ile Lys Glu Gln
                2005                2010                2015    
Cys Pro Leu Glu Ala Gly Leu His Ser Ser Ser Lys Val Thr Ile His
            2020                2025                2030        
Glu Cys Asp Glu Gly Ser Glu Pro Leu Gly Phe Trp Asp Ala Leu Gly
        2035                2040                2045            
Arg Arg Asp Arg Lys Ala Tyr Asp Cys Met Leu Gln Asp Pro Gly Ser
    2050                2055                2060                
Phe Asn Phe Ala Pro Arg Leu Phe Ile Leu Ser Ser Ser Ser Gly Asp
2065                2070                2075                2080
Phe Ala Ala Thr Glu Phe Val Tyr Pro Ala Arg Ala Pro Ser Val Val
                2085                2090                2095    
Ser Ser Met Pro Phe Leu Gln Glu Asp Leu Tyr Ser Ala Pro Gln Pro
            2100                2105                2110        
Ala Leu Phe Leu Val Asp Asn His His Glu Val Tyr Leu Trp Gln Gly
        2115                2120                2125            
Trp Trp Pro Ile Glu Asn Lys Ile Thr Gly Ser Ala Arg Ile Arg Trp
    2130                2135                2140                
Ala Ser Asp Arg Lys Ser Ala Met Glu Thr Val Leu Gln Tyr Cys Lys
2145                2150                2155                2160
Gly Lys Asn Leu Lys Lys Pro Ala Pro Lys Ser Tyr Leu Ile His Ala
                2165                2170                2175    
Gly Leu Glu Pro Leu Thr Phe Thr Asn Met Phe Pro Ser Trp Glu His
            2180                2185                2190        
Arg Glu Asp Ile Ala Glu Ile Thr Glu Met Asp Thr Glu Val Ser Asn
        2195                2200                2205            
Gln Ile Thr Leu Val Glu Asp Val Leu Ala Lys Leu Cys Lys Thr Ile
    2210                2215                2220                
Tyr Pro Leu Ala Asp Leu Leu Ala Arg Pro Leu Pro Glu Gly Val Asp
2225                2230                2235                2240
Pro Leu Lys Leu Glu Ile Tyr Leu Thr Asp Glu Asp Phe Glu Phe Ala
                2245                2250                2255    
Leu Asp Met Thr Arg Asp Glu Tyr Asn Ala Leu Pro Ala Trp Lys Gln
            2260                2265                2270        
Val Asn Leu Lys Lys Ala Lys Gly Leu Phe
        2275                2280        


<210> 7974
<211> 691
<212> PRT
<213> Homo sapiens

<400> 7974
Met Ile Arg Gly Arg Asn Ser Ala Thr Ser Ala Asp Glu Gln Pro His
 1               5                  10                  15      
Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys Gly Asn Phe Ala
            20                  25                  30          
Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Lys Glu Val Ala Val
        35                  40                  45              
Lys Ile Ile Asp Lys Thr Gln Leu Asn Ser Ser Ser Leu Gln Lys Leu
    50                  55                  60                  
Phe Arg Glu Val Arg Ile Met Lys Val Leu Asn His Pro Asn Ile Val
65                  70                  75                  80  
Lys Leu Phe Glu Val Ile Glu Thr Glu Lys Thr Leu Tyr Leu Val Met
                85                  90                  95      
Glu Tyr Ala Ser Gly Gly Glu Val Phe Asp Tyr Leu Val Ala His Gly
            100                 105                 110         
Arg Met Lys Glu Lys Glu Ala Arg Ala Lys Phe Arg Gln Ile Val Ser
        115                 120                 125             
Ala Val Gln Tyr Cys His Gln Lys Phe Ile Val His Arg Asp Leu Lys
    130                 135                 140                 
Ala Glu Asn Leu Leu Leu Asp Ala Asp Met Asn Ile Lys Ile Ala Asp
145                 150                 155                 160 
Phe Gly Phe Ser Asn Glu Phe Thr Phe Gly Asn Lys Leu Asp Thr Phe
                165                 170                 175     
Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe Gln Gly Lys Lys
            180                 185                 190         
Tyr Asp Gly Pro Glu Val Asp Val Trp Ser Leu Gly Val Ile Leu Tyr
        195                 200                 205             
Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly Gln Asn Leu Lys Glu
    210                 215                 220                 
Leu Arg Glu Arg Val Leu Arg Gly Lys Tyr Arg Ile Pro Phe Tyr Met
225                 230                 235                 240 
Ser Thr Asp Cys Glu Asn Leu Leu Lys Lys Phe Leu Ile Leu Asn Pro
                245                 250                 255     
Ser Lys Arg Gly Thr Leu Glu Gln Ile Met Lys Asp Arg Trp Met Asn
            260                 265                 270         
Val Gly His Glu Asp Asp Glu Leu Lys Pro Tyr Val Glu Pro Leu Pro
        275                 280                 285             
Asp Tyr Lys Asp Pro Arg Arg Thr Glu Leu Met Val Ser Met Gly Tyr
    290                 295                 300                 
Thr Arg Glu Glu Ile Gln Asp Ser Leu Val Gly Gln Arg Tyr Asn Glu
305                 310                 315                 320 
Val Met Ala Thr Tyr Leu Leu Leu Gly Tyr Lys Ser Ser Glu Leu Glu
                325                 330                 335     
Gly Asp Thr Ile Thr Leu Lys Pro Arg Pro Ser Ala Asp Leu Thr Asn
            340                 345                 350         
Ser Ser Ala Pro Ser Pro Ser His Lys Val Gln Arg Ser Val Ser Ala
        355                 360                 365             
Asn Pro Lys Gln Arg Arg Phe Ser Asp Gln Ala Gly Pro Ala Ile Pro
    370                 375                 380                 
Thr Ser Asn Ser Tyr Ser Lys Lys Thr Gln Ser Asn Asn Ala Glu Asn
385                 390                 395                 400 
Lys Arg Pro Glu Glu Asp Arg Glu Ser Gly Arg Lys Ala Ser Ser Thr
                405                 410                 415     
Ala Lys Val Pro Ala Ser Pro Leu Pro Gly Leu Glu Arg Lys Lys Thr
            420                 425                 430         
Thr Pro Thr Pro Ser Thr Asn Ser Val Leu Ser Thr Ser Thr Asn Arg
        435                 440                 445             
Ser Arg Asn Ser Pro Leu Leu Glu Arg Ala Ser Leu Gly Gln Ala Ser
    450                 455                 460                 
Ile Gln Asn Gly Lys Asp Ser Thr Ala Pro Gln Arg Val Pro Val Ala
465                 470                 475                 480 
Ser Pro Ser Ala His Asn Ile Ser Ser Ser Gly Gly Ala Pro Asp Arg
                485                 490                 495     
Thr Asn Phe Pro Arg Gly Val Ser Ser Arg Ser Thr Phe His Ala Gly
            500                 505                 510         
Gln Leu Arg Gln Val Arg Asp Gln Gln Asn Leu Pro Tyr Gly Val Thr
        515                 520                 525             
Pro Ala Ser Pro Ser Gly His Ser Gln Gly Arg Arg Gly Ala Ser Gly
    530                 535                 540                 
Ser Ile Phe Ser Lys Phe Thr Ser Lys Phe Val Arg Arg Asn Leu Asn
545                 550                 555                 560 
Glu Pro Glu Ser Lys Asp Arg Val Glu Thr Leu Arg Pro His Val Val
                565                 570                 575     
Gly Ser Gly Gly Asn Asp Lys Glu Lys Glu Glu Phe Arg Glu Ala Lys
            580                 585                 590         
Pro Arg Ser Leu Arg Phe Thr Trp Ser Met Lys Thr Thr Ser Ser Met
        595                 600                 605             
Glu Pro Asn Glu Met Met Arg Glu Ile Arg Lys Val Leu Asp Ala Asn
    610                 615                 620                 
Ser Cys Gln Ser Glu Leu His Glu Lys Tyr Met Leu Leu Cys Met His
625                 630                 635                 640 
Gly Thr Pro Gly His Glu Asp Phe Val Gln Trp Glu Met Glu Val Cys
                645                 650                 655     
Lys Leu Pro Arg Leu Ser Leu Asn Gly Val Arg Phe Lys Arg Ile Ser
            660                 665                 670         
Gly Thr Ser Met Ala Phe Lys Asn Ile Ala Ser Lys Ile Ala Asn Glu
        675                 680                 685             
Leu Lys Leu
    690     


<210> 7975
<211> 757
<212> PRT
<213> Homo sapiens

<400> 7975
Met Ile Arg Gly Arg Asn Ser Ala Thr Ser Ala Asp Glu Gln Pro His
 1               5                  10                  15      
Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys Gly Asn Phe Ala
            20                  25                  30          
Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Lys Glu Val Ala Val
        35                  40                  45              
Lys Ile Ile Asp Lys Thr Gln Leu Asn Ser Ser Ser Leu Gln Lys Leu
    50                  55                  60                  
Phe Arg Glu Val Arg Ile Met Lys Val Leu Asn His Pro Asn Ile Val
65                  70                  75                  80  
Lys Leu Phe Glu Val Ile Glu Thr Glu Lys Thr Leu Tyr Leu Val Met
                85                  90                  95      
Glu Tyr Ala Ser Gly Gly Glu Val Phe Asp Tyr Leu Val Ala His Gly
            100                 105                 110         
Arg Met Lys Glu Lys Glu Ala Arg Ala Lys Phe Arg Gln Val Val Ser
        115                 120                 125             
Ala Val Gln Tyr Cys His Gln Lys Phe Ile Val His Arg Asp Leu Lys
    130                 135                 140                 
Ala Glu Asn Leu Leu Leu Asp Ala Asp Met Asn Ile Lys Ile Ala Asp
145                 150                 155                 160 
Phe Gly Phe Ser Asn Glu Phe Thr Phe Gly Asn Lys Leu Asp Thr Phe
                165                 170                 175     
Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe Gln Gly Lys Lys
            180                 185                 190         
Tyr Asp Gly Pro Glu Val Asp Val Trp Ser Leu Gly Val Ile Leu Tyr
        195                 200                 205             
Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly Gln Asn Leu Lys Glu
    210                 215                 220                 
Leu Arg Glu Arg Val Leu Arg Gly Lys Tyr Arg Ile Pro Phe Tyr Met
225                 230                 235                 240 
Ser Thr Asp Cys Glu Asn Leu Leu Lys Lys Phe Leu Ile Leu Asn Pro
                245                 250                 255     
Ser Lys Arg Gly Thr Leu Glu Gln Ile Met Lys Asp Arg Trp Met Asn
            260                 265                 270         
Val Gly His Glu Asp Asp Glu Leu Lys Pro Tyr Val Glu Pro Leu Pro
        275                 280                 285             
Asp Tyr Lys Asp Pro Arg Arg Thr Glu Leu Met Val Ser Met Gly Tyr
    290                 295                 300                 
Thr Arg Glu Glu Ile Gln Asp Ser Leu Val Gly Gln Arg Tyr Asn Glu
305                 310                 315                 320 
Val Met Ala Thr Tyr Leu Leu Leu Gly Tyr Lys Ser Ser Glu Leu Glu
                325                 330                 335     
Gly Asp Thr Ile Thr Leu Lys Pro Arg Pro Ser Ala Asp Leu Thr Asn
            340                 345                 350         
Ser Ser Ala Pro Ser Pro Ser His Lys Val Gln Arg Ser Val Ser Ala
        355                 360                 365             
Asn Pro Lys Gln Arg Arg Phe Ser Asp Gln Ala Ala Gly Pro Ala Ile
    370                 375                 380                 
Pro Thr Ser Asn Ser Tyr Ser Lys Lys Thr Gln Ser Asn Asn Ala Glu
385                 390                 395                 400 
Asn Lys Arg Pro Glu Glu Asp Arg Glu Ser Gly Arg Lys Ala Ser Ser
                405                 410                 415     
Thr Ala Lys Val Pro Ala Ser Pro Leu Pro Gly Leu Glu Arg Lys Lys
            420                 425                 430         
Thr Thr Pro Thr Pro Ser Thr Asn Ser Val Leu Ser Thr Ser Thr Asn
        435                 440                 445             
Arg Ser Arg Asn Ser Pro Leu Leu Glu Arg Ala Ser Leu Gly Gln Ala
    450                 455                 460                 
Ser Ile Gln Asn Gly Lys Asp Ser Leu Thr Met Pro Gly Ser Arg Ala
465                 470                 475                 480 
Ser Thr Ala Ser Ala Ser Ala Ala Val Ser Ala Ala Arg Pro Arg Gln
                485                 490                 495     
His Gln Lys Ser Met Ser Ala Ser Val His Pro Asn Lys Ala Ser Gly
            500                 505                 510         
Leu Pro Pro Thr Glu Ser Asn Cys Glu Val Pro Arg Pro Arg Gln Val
        515                 520                 525             
Thr Ala Pro Gln Arg Val Pro Val Ala Ser Pro Ser Ala His Asn Ile
    530                 535                 540                 
Ser Ser Ser Gly Gly Ala Pro Asp Arg Thr Asn Phe Pro Arg Gly Val
545                 550                 555                 560 
Ser Ser Arg Ser Thr Phe His Ala Gly Gln Leu Arg Gln Val Arg Asp
                565                 570                 575     
Gln Gln Asn Leu Pro Tyr Gly Val Thr Pro Ala Ser Pro Ser Gly His
            580                 585                 590         
Ser Gln Gly Arg Arg Gly Ala Ser Gly Ser Ile Phe Ser Lys Phe Thr
        595                 600                 605             
Ser Lys Phe Val Arg Arg Asn Leu Ser Phe Arg Phe Ala Arg Arg Asn
    610                 615                 620                 
Leu Asn Glu Pro Glu Ser Lys Asp Arg Val Glu Thr Leu Arg Pro His
625                 630                 635                 640 
Val Val Gly Ser Gly Gly Asn Asp Lys Glu Lys Glu Glu Phe Arg Glu
                645                 650                 655     
Ala Lys Pro Arg Ser Leu Arg Phe Thr Trp Ser Met Lys Thr Thr Ser
            660                 665                 670         
Ser Met Glu Pro Asn Glu Met Met Arg Glu Ile Arg Lys Val Leu Asp
        675                 680                 685             
Ala Asn Ser Cys Gln Ser Glu Leu His Glu Lys Tyr Met Leu Leu Cys
    690                 695                 700                 
Met His Gly Thr Pro Gly His Glu Asp Phe Val Gln Trp Glu Met Glu
705                 710                 715                 720 
Val Cys Lys Leu Pro Arg Leu Ser Leu Asn Gly Val Arg Phe Lys Arg
                725                 730                 735     
Ile Ser Gly Thr Ser Met Ala Phe Lys Asn Ile Ala Ser Lys Ile Ala
            740                 745                 750         
Asn Glu Leu Lys Leu
        755         


<210> 7976
<211> 747
<212> PRT
<213> Homo sapiens

<400> 7976
Met Ile Arg Gly Arg Asn Ser Ala Thr Ser Ala Asp Glu Gln Pro His
 1               5                  10                  15      
Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys Gly Asn Phe Ala
            20                  25                  30          
Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Lys Glu Val Ala Val
        35                  40                  45              
Lys Ile Ile Asp Lys Thr Gln Leu Asn Ser Ser Ser Leu Gln Lys Leu
    50                  55                  60                  
Phe Arg Glu Val Arg Ile Met Lys Val Leu Asn His Pro Asn Ile Val
65                  70                  75                  80  
Lys Leu Phe Glu Val Ile Glu Thr Glu Lys Thr Leu Tyr Leu Val Met
                85                  90                  95      
Glu Tyr Ala Ser Gly Gly Glu Val Phe Asp Tyr Leu Val Ala His Gly
            100                 105                 110         
Arg Met Lys Glu Lys Glu Ala Arg Ala Lys Phe Arg Gln Val Val Ser
        115                 120                 125             
Ala Val Gln Tyr Cys His Gln Lys Phe Ile Val His Arg Asp Leu Lys
    130                 135                 140                 
Ala Glu Asn Leu Leu Leu Asp Ala Asp Met Asn Ile Lys Ile Ala Asp
145                 150                 155                 160 
Phe Gly Phe Ser Asn Glu Phe Thr Phe Gly Asn Lys Leu Asp Thr Phe
                165                 170                 175     
Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe Gln Gly Lys Lys
            180                 185                 190         
Tyr Asp Gly Pro Glu Val Asp Val Trp Ser Leu Gly Val Ile Leu Tyr
        195                 200                 205             
Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly Gln Asn Leu Lys Glu
    210                 215                 220                 
Leu Arg Glu Arg Val Leu Arg Gly Lys Tyr Arg Ile Pro Phe Tyr Met
225                 230                 235                 240 
Ser Thr Asp Cys Glu Asn Leu Leu Lys Lys Phe Leu Ile Leu Asn Pro
                245                 250                 255     
Ser Lys Arg Gly Thr Leu Glu Gln Ile Met Lys Asp Arg Trp Met Asn
            260                 265                 270         
Val Gly His Glu Asp Asp Glu Leu Lys Pro Tyr Val Glu Pro Leu Pro
        275                 280                 285             
Asp Tyr Lys Asp Pro Arg Arg Thr Glu Leu Met Val Ser Met Gly Tyr
    290                 295                 300                 
Thr Arg Glu Glu Ile Gln Asp Ser Leu Val Gly Gln Arg Tyr Asn Glu
305                 310                 315                 320 
Val Met Ala Thr Tyr Leu Leu Leu Gly Tyr Lys Ser Ser Glu Leu Glu
                325                 330                 335     
Gly Asp Thr Ile Thr Leu Lys Pro Arg Pro Ser Ala Asp Leu Thr Asn
            340                 345                 350         
Ser Ser Ala Pro Ser Pro Ser His Lys Val Gln Arg Ser Val Ser Ala
        355                 360                 365             
Asn Pro Lys Gln Arg Arg Phe Ser Asp Gln Ala Gly Pro Ala Ile Pro
    370                 375                 380                 
Thr Ser Asn Ser Tyr Ser Lys Lys Thr Gln Ser Asn Asn Ala Glu Asn
385                 390                 395                 400 
Lys Arg Pro Glu Glu Asp Arg Glu Ser Gly Arg Lys Ala Ser Ser Thr
                405                 410                 415     
Ala Lys Val Pro Ala Ser Pro Leu Pro Gly Leu Glu Arg Lys Lys Thr
            420                 425                 430         
Thr Pro Thr Pro Ser Thr Asn Ser Val Leu Ser Thr Ser Thr Asn Arg
        435                 440                 445             
Ser Arg Asn Ser Pro Leu Leu Glu Arg Ala Ser Leu Gly Gln Ala Ser
    450                 455                 460                 
Ile Gln Asn Gly Lys Asp Ser Leu Thr Met Pro Gly Ser Arg Ala Ser
465                 470                 475                 480 
Thr Ala Ser Ala Ser Ala Ala Val Ser Ala Ala Arg Pro Arg Gln His
                485                 490                 495     
Gln Lys Ser Met Ser Ala Ser Val His Pro Asn Lys Ala Ser Gly Leu
            500                 505                 510         
Pro Pro Thr Glu Ser Asn Cys Glu Val Pro Arg Pro Arg Gln Val Thr
        515                 520                 525             
Ala Pro Gln Arg Val Pro Val Ala Ser Pro Ser Ala His Asn Ile Ser
    530                 535                 540                 
Ser Ser Gly Gly Ala Pro Asp Arg Thr Asn Phe Pro Arg Gly Val Ser
545                 550                 555                 560 
Ser Arg Ser Thr Phe His Ala Gly Gln Leu Arg Gln Val Arg Asp Gln
                565                 570                 575     
Gln Asn Leu Pro Tyr Gly Val Thr Pro Ala Ser Pro Ser Gly His Ser
            580                 585                 590         
Gln Gly Arg Arg Gly Ala Ser Gly Ser Ile Phe Ser Lys Phe Thr Ser
        595                 600                 605             
Lys Phe Val Arg Arg Asn Leu Asn Glu Pro Glu Ser Lys Asp Arg Val
    610                 615                 620                 
Glu Thr Leu Arg Pro His Val Val Gly Ser Gly Gly Asn Asp Lys Glu
625                 630                 635                 640 
Lys Glu Glu Phe Arg Glu Ala Lys Pro Arg Ser Leu Arg Phe Thr Trp
                645                 650                 655     
Ser Met Lys Thr Thr Ser Ser Met Glu Pro Asn Glu Met Met Arg Glu
            660                 665                 670         
Ile Arg Lys Val Leu Asp Ala Asn Ser Cys Gln Ser Glu Leu His Glu
        675                 680                 685             
Lys Tyr Met Leu Leu Cys Met His Gly Thr Pro Gly His Glu Asp Phe
    690                 695                 700                 
Val Gln Trp Glu Met Glu Val Cys Lys Leu Pro Arg Leu Ser Leu Asn
705                 710                 715                 720 
Gly Val Arg Phe Lys Arg Ile Ser Gly Thr Ser Met Ala Phe Lys Asn
                725                 730                 735     
Ile Ala Ser Lys Ile Ala Asn Glu Leu Lys Leu
            740                 745         


<210> 7977
<211> 312
<212> PRT
<213> Homo sapiens

<400> 7977
Met Ala Ala Gly Val Asp Cys Gly Asp Gly Val Gly Ala Arg Gln His
 1               5                  10                  15      
Val Phe Leu Val Ser Glu Tyr Leu Lys Asp Ala Ser Lys Lys Met Lys
            20                  25                  30          
Asn Gly Leu Met Phe Val Lys Leu Val Asn Pro Cys Ser Gly Glu Gly
        35                  40                  45              
Ala Ile Tyr Leu Phe Asn Met Cys Leu Gln Gln Leu Leu Glu Val Lys
    50                  55                  60                  
Val Phe Lys Glu Lys His His Ser Trp Phe Ile Asn Gln Ser Val Gln
65                  70                  75                  80  
Ser Gly Gly Leu Leu His Phe Ala Thr Pro Val Asp Pro Leu Phe Leu
                85                  90                  95      
Leu Leu His Tyr Leu Ile Lys Ala Asp Lys Glu Gly Lys Phe Gln Pro
            100                 105                 110         
Leu Asp Gln Val Val Val Asp Asn Val Phe Pro Asn Cys Ile Leu Leu
        115                 120                 125             
Leu Lys Leu Pro Gly Leu Glu Lys Leu Leu His His Val Thr Glu Glu
    130                 135                 140                 
Lys Gly Asn Pro Glu Ile Asp Asn Lys Lys Tyr Tyr Lys Tyr Ser Lys
145                 150                 155                 160 
Glu Lys Thr Leu Lys Trp Leu Glu Lys Lys Val Asn Gln Thr Val Ala
                165                 170                 175     
Ala Leu Lys Thr Asn Asn Val Asn Val Ser Ser Arg Val Gln Ser Thr
            180                 185                 190         
Ala Phe Phe Ser Gly Asp Gln Ala Ser Thr Asp Lys Glu Glu Asp Tyr
        195                 200                 205             
Ile Arg Tyr Ala His Gly Leu Ile Ser Asp Tyr Ile Pro Lys Glu Leu
    210                 215                 220                 
Ser Asp Asp Leu Ser Lys Tyr Leu Lys Leu Pro Glu Pro Ser Ala Ser
225                 230                 235                 240 
Leu Pro Asn Pro Pro Ser Lys Lys Ile Lys Leu Ser Asp Glu Pro Val
                245                 250                 255     
Glu Ala Lys Glu Asp Tyr Thr Lys Phe Asn Thr Lys Asp Leu Lys Thr
            260                 265                 270         
Glu Lys Lys Asn Ser Lys Met Thr Ala Ala Gln Lys Ala Leu Ala Lys
        275                 280                 285             
Val Asp Lys Ser Gly Met Lys Ser Ile Asp Thr Phe Phe Gly Val Lys
    290                 295                 300                 
Asn Lys Lys Lys Ile Gly Lys Val
305                 310         


<210> 7978
<211> 331
<212> PRT
<213> Homo sapiens

<400> 7978
Met Ala Ala Gly Val Asp Cys Gly Asp Gly Val Gly Ala Arg Gln His
 1               5                  10                  15      
Val Phe Leu Val Ser Glu Tyr Leu Lys Asp Ala Ser Lys Lys Met Lys
            20                  25                  30          
Asn Gly Leu Met Phe Val Lys Leu Val Asn Pro Cys Ser Gly Glu Gly
        35                  40                  45              
Ala Ile Tyr Leu Phe Asn Met Cys Leu Gln Gln Leu Phe Glu Val Lys
    50                  55                  60                  
Val Phe Lys Glu Lys His His Ser Trp Phe Ile Asn Gln Ser Val Gln
65                  70                  75                  80  
Ser Gly Gly Leu Leu His Phe Ala Thr Pro Val Asp Pro Leu Phe Leu
                85                  90                  95      
Leu Leu His Tyr Leu Ile Lys Ala Asp Lys Glu Gly Lys Phe Gln Pro
            100                 105                 110         
Leu Asp Gln Val Val Val Asp Asn Val Phe Pro Asn Cys Ile Leu Leu
        115                 120                 125             
Leu Lys Leu Pro Gly Leu Glu Lys Leu Leu His His Val Thr Glu Glu
    130                 135                 140                 
Lys Gly Asn Pro Glu Ile Asp Asn Lys Lys Tyr Tyr Lys Tyr Ser Lys
145                 150                 155                 160 
Glu Lys Thr Leu Lys Trp Leu Glu Lys Lys Val Asn Gln Thr Val Ala
                165                 170                 175     
Ala Leu Lys Thr Asn Asn Val Asn Val Ser Ser Arg Val Gln Ser Thr
            180                 185                 190         
Ala Phe Phe Ser Gly Asp Gln Ala Ser Thr Asp Lys Glu Lys Asp Tyr
        195                 200                 205             
Ile Arg Tyr Ala His Gly Leu Ile Ser Asp Tyr Ile Pro Lys Glu Leu
    210                 215                 220                 
Ser Asp Asp Leu Ser Lys Tyr Leu Lys Leu Pro Glu Pro Ser Ala Ser
225                 230                 235                 240 
Leu Pro Asn Pro Pro Ser Lys Lys Ile Lys Leu Ser Asp Glu Pro Val
                245                 250                 255     
Glu Ala Lys Glu Asp Tyr Thr Lys Phe Asn Thr Lys Asp Leu Lys Thr
            260                 265                 270         
Glu Lys Lys Asn Ser Lys Met Thr Ala Ala Gln Lys Ala Leu Ala Lys
        275                 280                 285             
Val Asp Lys Ser Gly Met Lys Ser Ile Asp Thr Phe Phe Gly Val Lys
    290                 295                 300                 
Lys Lys Leu Glu Arg Phe Glu Thr Leu Lys Ile Lys Ser Ser Lys Asn
305                 310                 315                 320 
Ile Cys Phe Leu His Val Ser Val Cys Pro Ser
                325                 330     


<210> 7979
<211> 740
<212> PRT
<213> Homo sapiens

<400> 7979
Met Asn Glu His Leu Ser Ser Leu Ile Lys Lys Lys Arg Lys Cys Met
 1               5                  10                  15      
Gln Pro Lys Asp Phe Asn Phe Lys Thr Pro Glu Asn Asp Lys Arg Phe
            20                  25                  30          
Gln Lys Lys Phe Glu Lys Met Ala Lys Glu Leu Gln Arg Gln Lys Thr
        35                  40                  45              
Asn Leu Asp Asp Asp Val Pro Ile Leu Leu Phe Glu Ser Asn Gly Ser
    50                  55                  60                  
Leu Ile Tyr Thr Pro Thr Ile Glu Ile Asn Ser Ser His His Ser Ala
65                  70                  75                  80  
Met Glu Lys Arg Leu Gln Glu Met Lys Glu Lys Arg Glu Asn Leu Ser
                85                  90                  95      
Pro Thr Ser Ser Gln Met Ile Gln Gln Ser His Asp Asn Pro Ser Asn
            100                 105                 110         
Ser Leu Cys Glu Ala Pro Leu Asn Ile Ser Arg Asp Thr Leu Cys Ser
        115                 120                 125             
Asp Glu Tyr Phe Ala Gly Gly Leu His Ser Ser Phe Asp Asp Leu Cys
    130                 135                 140                 
Gly Asn Ser Gly Cys Gly Asn Gln Glu Arg Lys Leu Glu Gly Ser Ile
145                 150                 155                 160 
Asn Asp Ile Lys Ser Asp Val Cys Ile Ser Ser Leu Val Leu Lys Ala
                165                 170                 175     
Asn Asn Ile His Ser Ser Pro Ser Phe Thr His Leu Asp Lys Ser Ser
            180                 185                 190         
Pro Gln Lys Phe Leu Ser Asn Leu Ser Lys Glu Glu Ile Asn Leu Gln
        195                 200                 205             
Arg Asn Ile Ala Gly Lys Val Val Thr Pro His Gln Lys Gln Ala Ala
    210                 215                 220                 
Gly Met Ser Gln Glu Thr Phe Glu Glu Lys Tyr Arg Leu Ser Pro Thr
225                 230                 235                 240 
Leu Ser Ser Thr Lys Gly His Leu Leu Ile His Ser Arg Pro Arg Ser
                245                 250                 255     
Ser Ser Val Lys Arg Lys Arg Val Ser His Gly Ser His Ser Pro Pro
            260                 265                 270         
Lys Glu Lys Cys Lys Arg Lys Arg Ser Thr Arg Arg Ser Ile Met Pro
        275                 280                 285             
Arg Leu Gln Leu Cys Arg Ser Glu Gly Arg Leu Gln His Val Ala Gly
    290                 295                 300                 
Pro Ala Leu Glu Ala Leu Ser Cys Gly Glu Ser Ser Tyr Asp Asp Tyr
305                 310                 315                 320 
Phe Ser Pro Asp Asn Leu Lys Glu Arg Tyr Ser Glu Asn Leu Pro Pro
                325                 330                 335     
Glu Ser Gln Leu Pro Ser Ser Pro Ala Gln Leu Ser Cys Arg Ser Leu
            340                 345                 350         
Ser Lys Lys Glu Arg Thr Ser Ile Phe Glu Met Ser Asp Phe Ser Cys
        355                 360                 365             
Val Gly Lys Lys Thr Arg Thr Val Asp Ile Thr Asn Phe Thr Ala Lys
    370                 375                 380                 
Thr Ile Ser Ser Pro Arg Lys Thr Gly Asn Gly Glu Gly Arg Ala Thr
385                 390                 395                 400 
Ser Ser Cys Val Thr Ser Ala Pro Glu Glu Ala Leu Arg Cys Cys Arg
                405                 410                 415     
Gln Ala Gly Lys Glu Asp Ala Cys Pro Glu Gly Asn Gly Phe Ser Tyr
            420                 425                 430         
Thr Ile Glu Asp Pro Ala Leu Pro Lys Gly His Asp Asp Asp Leu Thr
        435                 440                 445             
Pro Leu Glu Gly Ser Leu Glu Glu Met Lys Glu Ala Val Gly Leu Lys
    450                 455                 460                 
Ser Thr Gln Asn Lys Gly Thr Thr Ser Lys Ile Ser Asn Ser Ser Glu
465                 470                 475                 480 
Gly Glu Ala Gln Ser Glu His Glu Pro Cys Phe Ile Val Asp Cys Asn
                485                 490                 495     
Met Glu Thr Ser Thr Glu Glu Lys Glu Asn Leu Pro Gly Gly Tyr Ser
            500                 505                 510         
Gly Ser Val Lys Asn Arg Pro Thr Arg His Asp Val Leu Asp Asp Ser
        515                 520                 525             
Cys Asp Gly Phe Lys Asp Leu Ile Lys Pro His Glu Glu Leu Lys Lys
    530                 535                 540                 
Ser Gly Arg Gly Lys Lys Pro Thr Arg Thr Leu Val Met Thr Ser Met
545                 550                 555                 560 
Pro Ser Glu Lys Gln Asn Val Val Ile Gln Val Val Asp Lys Leu Lys
                565                 570                 575     
Gly Phe Ser Ile Ala Pro Asp Val Cys Glu Thr Thr Thr His Val Leu
            580                 585                 590         
Ser Gly Lys Pro Leu Arg Thr Leu Asn Val Leu Leu Gly Ile Ala Arg
        595                 600                 605             
Gly Cys Trp Val Leu Ser Tyr Asp Trp Val Leu Trp Ser Leu Glu Leu
    610                 615                 620                 
Gly His Trp Ile Ser Glu Glu Pro Phe Glu Leu Ser His His Phe Pro
625                 630                 635                 640 
Ala Ala Pro Leu Cys Arg Ser Glu Cys His Leu Ser Ala Gly Pro Tyr
                645                 650                 655     
Arg Gly Thr Leu Phe Ala Asp Gln Pro Val Met Phe Val Ser Pro Ala
            660                 665                 670         
Ser Ser Pro Pro Val Ala Lys Leu Cys Glu Leu Val His Leu Cys Gly
        675                 680                 685             
Gly Arg Val Ser Gln Val Pro Arg Gln Ala Ser Ile Val Ile Gly Pro
    690                 695                 700                 
Tyr Ser Gly Lys Lys Lys Ala Thr Val Lys Tyr Leu Ser Glu Lys Trp
705                 710                 715                 720 
Val Leu Asp Ser Ile Thr Gln His Lys Val Cys Ala Pro Glu Asn Tyr
                725                 730                 735     
Leu Leu Ser Gln
            740 


<210> 7980
<211> 1053
<212> PRT
<213> Homo sapiens

<400> 7980
Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu
 1               5                  10                  15      
Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp
            20                  25                  30          
Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn
        35                  40                  45              
His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys
    50                  55                  60                  
Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu
65                  70                  75                  80  
Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys
                85                  90                  95      
Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser
            100                 105                 110         
Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly
        115                 120                 125             
Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys
    130                 135                 140                 
Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala
145                 150                 155                 160 
Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val
                165                 170                 175     
Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala
            180                 185                 190         
Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala
        195                 200                 205             
Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln
    210                 215                 220                 
Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn
225                 230                 235                 240 
Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr
                245                 250                 255     
Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val
            260                 265                 270         
Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala
        275                 280                 285             
Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser
    290                 295                 300                 
Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr
305                 310                 315                 320 
Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro
                325                 330                 335     
Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala
            340                 345                 350         
Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala
        355                 360                 365             
Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys
    370                 375                 380                 
Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His
385                 390                 395                 400 
Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly
                405                 410                 415     
His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His
            420                 425                 430         
Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys
        435                 440                 445             
Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro
    450                 455                 460                 
Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr
465                 470                 475                 480 
Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys
                485                 490                 495     
Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser
            500                 505                 510         
Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr
        515                 520                 525             
Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro
    530                 535                 540                 
Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys
545                 550                 555                 560 
Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser
                565                 570                 575     
Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg
            580                 585                 590         
Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn
        595                 600                 605             
Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr
    610                 615                 620                 
Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met
625                 630                 635                 640 
Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr
                645                 650                 655     
Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr
            660                 665                 670         
Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile
        675                 680                 685             
Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser
    690                 695                 700                 
Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro
705                 710                 715                 720 
Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val
                725                 730                 735     
Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly
            740                 745                 750         
Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly
        755                 760                 765             
Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser
    770                 775                 780                 
Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser
785                 790                 795                 800 
Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg
                805                 810                 815     
Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala
            820                 825                 830         
Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro
        835                 840                 845             
Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg
    850                 855                 860                 
Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser
865                 870                 875                 880 
Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys
                885                 890                 895     
Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn
            900                 905                 910         
Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg
        915                 920                 925             
Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr
    930                 935                 940                 
Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro
945                 950                 955                 960 
Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu
                965                 970                 975     
Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser
            980                 985                 990         
Gly Gly Val Pro Thr Leu Pro Val Ser Leu Gly Ala Thr Ser Val Val
        995                 1000                1005            
Asn Asn Ala Thr Val Ser Lys Met Asp Gly Ser Gln Ser Gly Ile Ser
    1010                1015                1020                
Ala Asp Val Glu Lys Pro Ser Ala Thr Asp Gly Val Pro Lys His Gln
1025                1030                1035                1040
Phe Pro His Phe Leu Glu Glu Asn Lys Ile Ala Val Ser
                1045                1050            


<210> 7981
<211> 468
<212> PRT
<213> Homo sapiens

<400> 7981
Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser
 1               5                  10                  15      
Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln
            20                  25                  30          
Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu
        35                  40                  45              
Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile
    50                  55                  60                  
Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr
65                  70                  75                  80  
Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Thr Leu Ala Leu
                85                  90                  95      
Arg Phe Gly Asn Gln Thr Leu Asn Tyr Arg Leu Phe His Asp Gly Lys
            100                 105                 110         
His Phe Val Gly Glu Lys Arg Phe Glu Ser Ile His Asp Leu Val Thr
        115                 120                 125             
Asp Gly Leu Ile Thr Leu Tyr Ile Glu Thr Lys Ala Ala Glu Tyr Ile
    130                 135                 140                 
Ser Lys Met Thr Thr Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Thr
145                 150                 155                 160 
Leu Leu Arg Glu Lys Val Ser Arg Arg Leu Ser Arg Ser Lys Asn Glu
                165                 170                 175     
Pro Arg Lys Thr Asn Val Thr His Glu Glu His Thr Ala Val Glu Lys
            180                 185                 190         
Ile Ser Ser Leu Val Arg Arg Ala Ala Leu Thr His Asn Asp Asn His
        195                 200                 205             
Phe Asn Tyr Glu Lys Thr His Asn Phe Lys Val His Thr Phe Arg Gly
    210                 215                 220                 
Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala
225                 230                 235                 240 
Gln Gly Val Arg Cys Ser Asp Cys Gly Leu Asn Val His Lys Gln Cys
                245                 250                 255     
Ser Lys His Val Pro Asn Asp Cys Gln Pro Asp Leu Lys Arg Ile Lys
            260                 265                 270         
Lys Val Tyr Cys Cys Asp Leu Thr Thr Leu Val Lys Ala His Asn Thr
        275                 280                 285             
Gln Arg Pro Met Val Val Asp Ile Cys Ile Arg Glu Ile Glu Ala Arg
    290                 295                 300                 
Gly Leu Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Thr Glu His
305                 310                 315                 320 
Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp
                325                 330                 335     
Ile Ser Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Thr Gly Ala Leu
            340                 345                 350         
Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro Val Ile Thr Tyr Asp Thr
        355                 360                 365             
Tyr Ser Lys Phe Ile Asp Ala Ala Lys Ile Ser Asn Ala Asp Glu Arg
    370                 375                 380                 
Leu Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr
385                 390                 395                 400 
Glu Thr Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Thr Met Asn
                405                 410                 415     
Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly
            420                 425                 430         
Pro Thr Leu Met Arg Pro Pro Glu Asp Ser Thr Leu Thr Thr Leu His
        435                 440                 445             
Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu
    450                 455                 460                 
Asp Val Leu Phe
465             


<210> 7982
<211> 2089
<212> PRT
<213> Homo sapiens

<400> 7982
Met Glu Asp Thr Gln Ala Ile Asp Trp Asp Val Glu Glu Glu Glu Glu
 1               5                  10                  15      
Thr Glu Gln Ser Ser Glu Ser Leu Arg Cys Asn Val Glu Pro Val Gly
            20                  25                  30          
Arg Leu His Ile Phe Ser Gly Ala His Gly Pro Glu Lys Asp Phe Pro
        35                  40                  45              
Leu His Leu Gly Lys Asn Val Val Gly Arg Met Pro Asp Cys Ser Val
    50                  55                  60                  
Ala Leu Pro Phe Pro Ser Ile Ser Lys Gln His Ala Glu Ile Glu Ile
65                  70                  75                  80  
Leu Ala Trp Asp Lys Ala Pro Ile Leu Arg Asp Cys Gly Ser Leu Asn
                85                  90                  95      
Gly Thr Gln Ile Leu Arg Pro Pro Lys Val Leu Ser Pro Gly Val Ser
            100                 105                 110         
His Arg Leu Arg Asp Gln Glu Leu Ile Leu Phe Ala Asp Leu Leu Cys
        115                 120                 125             
Gln Tyr His Arg Leu Asp Val Ser Leu Pro Phe Val Ser Arg Gly Pro
    130                 135                 140                 
Leu Thr Val Glu Glu Thr Pro Arg Val Gln Gly Glu Thr Gln Pro Gln
145                 150                 155                 160 
Arg Leu Leu Leu Ala Glu Asp Ser Glu Glu Glu Val Asp Phe Leu Ser
                165                 170                 175     
Glu Arg Arg Met Val Lys Lys Ser Arg Thr Thr Ser Ser Ser Val Ile
            180                 185                 190         
Val Pro Glu Ser Asp Glu Glu Gly His Ser Pro Val Leu Gly Gly Leu
        195                 200                 205             
Gly Pro Pro Phe Ala Phe Asn Leu Asn Ser Asp Thr Asp Val Glu Glu
    210                 215                 220                 
Gly Gln Gln Pro Ala Thr Glu Glu Ala Ser Ser Ala Ala Arg Arg Gly
225                 230                 235                 240 
Ala Thr Val Glu Ala Lys Gln Ser Glu Ala Glu Val Val Thr Glu Ile
                245                 250                 255     
Gln Leu Glu Lys Asp Gln Pro Leu Val Lys Glu Arg Asp Asn Asp Thr
            260                 265                 270         
Lys Val Lys Arg Gly Ala Gly Asn Gly Val Val Pro Ala Gly Val Ile
        275                 280                 285             
Leu Glu Arg Ser Gln Pro Pro Gly Glu Asp Ser Asp Thr Asp Val Asp
    290                 295                 300                 
Asp Asp Ser Arg Pro Pro Gly Arg Pro Ala Glu Val His Leu Glu Arg
305                 310                 315                 320 
Ala Gln Pro Phe Gly Phe Ile Asp Ser Asp Thr Asp Ala Glu Glu Glu
                325                 330                 335     
Arg Ile Pro Ala Thr Pro Val Val Ile Pro Met Lys Lys Arg Lys Ile
            340                 345                 350         
Phe His Gly Val Gly Thr Arg Gly Pro Gly Ala Pro Gly Leu Ala His
        355                 360                 365             
Leu Gln Glu Ser Gln Ala Gly Ser Asp Thr Asp Val Glu Glu Gly Lys
    370                 375                 380                 
Ala Pro Gln Ala Val Pro Leu Glu Lys Ser Gln Ala Ser Met Val Ile
385                 390                 395                 400 
Asn Ser Asp Thr Asp Asp Glu Glu Glu Val Ser Ala Ala Leu Thr Leu
                405                 410                 415     
Ala His Leu Lys Glu Ser Gln Pro Ala Ile Trp Asn Arg Asp Ala Glu
            420                 425                 430         
Glu Asp Met Pro Gln Arg Val Val Leu Leu Gln Arg Ser Gln Thr Thr
        435                 440                 445             
Thr Glu Arg Asp Ser Asp Thr Asp Val Glu Glu Glu Glu Leu Pro Val
    450                 455                 460                 
Glu Asn Arg Glu Ala Val Leu Lys Asp His Thr Lys Ile Arg Ala Leu
465                 470                 475                 480 
Val Arg Ala His Ser Glu Lys Asp Gln Pro Pro Phe Gly Asp Ser Asp
                485                 490                 495     
Asp Ser Val Glu Ala Asp Lys Ser Ser Pro Gly Ile His Leu Glu Arg
            500                 505                 510         
Ser Gln Ala Ser Thr Thr Val Asp Ile Asn Thr Gln Val Glu Lys Glu
        515                 520                 525             
Val Pro Pro Gly Ser Ala Ile Met His Ile Lys Lys His Gln Val Ser
    530                 535                 540                 
Val Glu Gly Thr Asn Gln Thr Asp Val Lys Ala Val Gly Gly Pro Ala
545                 550                 555                 560 
Lys Leu Leu Val Val Ser Leu Glu Glu Ala Trp Pro Leu His Gly Asp
                565                 570                 575     
Cys Glu Thr Asp Ala Glu Glu Gly Thr Ser Leu Thr Ala Ser Val Val
            580                 585                 590         
Ala Asp Val Arg Lys Ser Gln Leu Pro Ala Glu Gly Asp Ala Gly Ala
        595                 600                 605             
Glu Trp Ala Ala Ala Val Leu Lys Gln Glu Arg Ala His Glu Val Gly
    610                 615                 620                 
Ala Gln Gly Gly Pro Pro Val Ala Gln Val Glu Gln Asp Leu Pro Ile
625                 630                 635                 640 
Ser Arg Glu Asn Leu Thr Asp Leu Val Val Asp Thr Asp Thr Leu Gly
                645                 650                 655     
Glu Ser Thr Gln Pro Gln Arg Glu Gly Ala Gln Val Pro Thr Gly Arg
            660                 665                 670         
Glu Arg Glu Gln His Val Gly Gly Thr Lys Asp Ser Glu Asp Asn Tyr
        675                 680                 685             
Gly Asp Ser Glu Asp Leu Asp Leu Gln Ala Thr Gln Cys Phe Leu Glu
    690                 695                 700                 
Asn Gln Gly Leu Glu Ala Val Gln Ser Met Glu Asp Glu Pro Thr Gln
705                 710                 715                 720 
Ala Phe Met Leu Thr Pro Pro Gln Glu Leu Gly Pro Ser His Cys Ser
                725                 730                 735     
Phe Gln Thr Thr Gly Thr Leu Asp Glu Pro Trp Glu Val Leu Ala Thr
            740                 745                 750         
Gln Pro Phe Cys Leu Arg Glu Ser Glu Asp Ser Glu Thr Gln Pro Phe
        755                 760                 765             
Asp Thr His Leu Glu Ala Tyr Gly Pro Cys Leu Ser Pro Pro Arg Ala
    770                 775                 780                 
Ile Pro Gly Asp Gln His Pro Glu Ser Pro Val His Thr Glu Pro Met
785                 790                 795                 800 
Gly Ile Gln Gly Arg Gly Arg Gln Thr Val Asp Lys Val Met Gly Ile
                805                 810                 815     
Pro Lys Glu Thr Ala Glu Arg Val Gly Pro Glu Arg Gly Pro Leu Glu
            820                 825                 830         
Arg Glu Thr Glu Lys Leu Leu Pro Glu Arg Gln Thr Asp Val Thr Gly
        835                 840                 845             
Glu Glu Glu Leu Thr Lys Gly Lys Gln Asp Arg Glu Gln Lys Gln Leu
    850                 855                 860                 
Leu Ala Arg Asp Thr Gln Arg Gln Glu Ser Asp Lys Asn Gly Glu Ser
865                 870                 875                 880 
Ala Ser Pro Glu Arg Asp Arg Glu Ser Leu Lys Val Glu Ile Glu Thr
                885                 890                 895     
Ser Glu Glu Ile Gln Glu Lys Gln Val Gln Lys Gln Thr Leu Pro Ser
            900                 905                 910         
Lys Ala Phe Glu Arg Glu Val Glu Arg Pro Val Ala Asn Arg Glu Cys
        915                 920                 925             
Asp Pro Ala Glu Leu Glu Glu Lys Val Pro Lys Val Ile Leu Glu Arg
    930                 935                 940                 
Asp Thr Gln Arg Gly Glu Pro Glu Gly Gly Ser Gln Asp Gln Lys Gly
945                 950                 955                 960 
Gln Ala Ser Ser Pro Thr Pro Glu Pro Gly Val Gly Ala Gly Asp Leu
                965                 970                 975     
Pro Gly Pro Thr Ser Ala Pro Val Pro Ser Gly Ser Gln Ser Gly Gly
            980                 985                 990         
Arg Gly Ser Pro Val Ser Pro Arg Arg His Gln Lys Gly Leu Leu Asn
        995                 1000                1005            
Cys Lys Met Pro Pro Ala Glu Lys Ala Ser Arg Ile Arg Ala Ala Glu
    1010                1015                1020                
Lys Val Ser Arg Gly Asp Gln Glu Ser Pro Asp Ala Cys Leu Pro Pro
1025                1030                1035                1040
Ala Val Pro Glu Ala Pro Ala Pro Pro Gln Lys Pro Leu Asn Ser Gln
                1045                1050                1055    
Ser Gln Lys His Leu Ala Pro Pro Pro Leu Leu Ser Pro Leu Leu Pro
            1060                1065                1070        
Ser Ile Lys Pro Thr Val Arg Lys Thr Arg Gln Asp Gly Ser Gln Glu
        1075                1080                1085            
Ala Pro Glu Ala Pro Leu Ser Ser Glu Leu Glu Pro Phe His Pro Lys
    1090                1095                1100                
Pro Lys Ile Arg Thr Arg Lys Ser Ser Arg Met Thr Pro Phe Pro Ala
1105                1110                1115                1120
Thr Ser Ala Ala Pro Glu Pro His Pro Ser Thr Ser Thr Ala Gln Pro
                1125                1130                1135    
Val Thr Pro Lys Pro Thr Ser Gln Ala Thr Arg Ser Arg Thr Asn Arg
            1140                1145                1150        
Ser Ser Val Lys Thr Pro Glu Pro Val Val Pro Thr Ala Pro Glu Leu
        1155                1160                1165            
Gln Pro Ser Thr Ser Thr Asp Gln Pro Val Thr Ser Glu Pro Thr Ser
    1170                1175                1180                
Gln Val Thr Arg Gly Arg Lys Ser Arg Ser Ser Val Lys Thr Pro Glu
1185                1190                1195                1200
Thr Val Val Pro Thr Ala Leu Glu Leu Gln Pro Ser Thr Ser Thr Asp
                1205                1210                1215    
Arg Pro Val Thr Ser Glu Pro Thr Ser Gln Ala Thr Arg Gly Arg Lys
            1220                1225                1230        
Asn Arg Ser Ser Val Lys Thr Pro Glu Pro Val Val Pro Thr Ala Pro
        1235                1240                1245            
Glu Leu Gln Pro Ser Thr Ser Thr Asp Gln Pro Val Thr Ser Glu Pro
    1250                1255                1260                
Thr Tyr Gln Ala Thr Arg Gly Arg Lys Asn Arg Ser Ser Val Lys Thr
1265                1270                1275                1280
Pro Glu Pro Val Val Pro Thr Ala Pro Glu Leu Arg Pro Ser Thr Ser
                1285                1290                1295    
Thr Asp Arg Pro Val Thr Pro Lys Pro Thr Ser Arg Thr Thr Arg Ser
            1300                1305                1310        
Arg Thr Asn Met Ser Ser Val Lys Thr Pro Glu Thr Val Val Pro Thr
        1315                1320                1325            
Ala Pro Glu Leu Gln Ile Ser Thr Ser Thr Asp Gln Pro Val Thr Pro
    1330                1335                1340                
Lys Pro Thr Ser Arg Thr Thr Arg Ser Arg Thr Asn Met Ser Ser Val
1345                1350                1355                1360
Lys Asn Pro Glu Ser Thr Val Pro Ile Ala Pro Glu Leu Pro Pro Ser
                1365                1370                1375    
Thr Ser Thr Glu Gln Pro Val Thr Pro Glu Pro Thr Ser Arg Ala Thr
            1380                1385                1390        
Arg Gly Arg Lys Asn Arg Ser Ser Gly Lys Thr Pro Glu Thr Leu Val
        1395                1400                1405            
Pro Thr Ala Pro Lys Leu Glu Pro Ser Thr Ser Thr Asp Gln Pro Val
    1410                1415                1420                
Thr Pro Glu Pro Thr Ser Gln Ala Thr Arg Gly Arg Thr Asn Arg Ser
1425                1430                1435                1440
Ser Val Lys Thr Pro Glu Thr Val Val Pro Thr Ala Pro Glu Leu Gln
                1445                1450                1455    
Pro Ser Thr Ser Thr Asp Gln Pro Val Thr Pro Glu Pro Thr Ser Gln
            1460                1465                1470        
Ala Thr Arg Gly Arg Thr Asp Arg Ser Ser Val Lys Thr Pro Glu Thr
        1475                1480                1485            
Val Val Pro Thr Ala Pro Glu Leu Gln Ala Ser Ala Ser Thr Asp Gln
    1490                1495                1500                
Pro Val Thr Ser Glu Pro Thr Ser Arg Thr Thr Arg Gly Arg Lys Asn
1505                1510                1515                1520
Arg Ser Ser Val Lys Thr Pro Glu Thr Val Val Pro Ala Ala Pro Glu
                1525                1530                1535    
Leu Gln Pro Pro Thr Ser Thr Asp Arg Pro Val Thr Pro Glu Pro Thr
            1540                1545                1550        
Ser Arg Ala Thr Arg Gly Arg Thr Asn Arg Ser Ser Val Lys Thr Pro
        1555                1560                1565            
Glu Ser Ile Val Pro Ile Ala Pro Glu Leu Gln Pro Ser Thr Ser Arg
    1570                1575                1580                
Asn Gln Leu Val Thr Pro Glu Pro Thr Ser Arg Ala Thr Arg Cys Arg
1585                1590                1595                1600
Thr Asn Arg Ser Ser Val Lys Thr Pro Glu Pro Val Val Pro Thr Ala
                1605                1610                1615    
Pro Glu Pro His Pro Thr Thr Ser Thr Asp Gln Pro Val Thr Pro Lys
            1620                1625                1630        
Leu Thr Ser Arg Ala Thr Arg Arg Lys Thr Asn Arg Ser Ser Val Lys
        1635                1640                1645            
Thr Pro Lys Pro Val Glu Pro Ala Ala Ser Asp Leu Glu Pro Phe Thr
    1650                1655                1660                
Pro Thr Asp Gln Ser Val Thr Pro Glu Ala Ile Ala Gln Gly Gly Gln
1665                1670                1675                1680
Ser Lys Thr Leu Arg Ser Ser Thr Val Arg Ala Met Pro Val Pro Thr
                1685                1690                1695    
Thr Pro Glu Phe Gln Ser Pro Val Thr Thr Asp Gln Pro Ile Ser Pro
            1700                1705                1710        
Glu Pro Ile Thr Gln Pro Ser Cys Ile Lys Arg Gln Arg Ala Ala Gly
        1715                1720                1725            
Asn Pro Gly Ser Leu Ala Ala Pro Ile Asp His Lys Pro Cys Ser Ala
    1730                1735                1740                
Pro Leu Glu Pro Lys Ser Gln Ala Ser Arg Asn Gln Arg Trp Gly Ala
1745                1750                1755                1760
Val Arg Ala Ala Glu Ser Leu Thr Ala Ile Pro Glu Pro Ala Ser Pro
                1765                1770                1775    
Gln Leu Leu Glu Thr Pro Ile His Ala Ser Gln Ile Gln Lys Val Glu
            1780                1785                1790        
Pro Ala Gly Arg Ser Arg Phe Thr Pro Glu Leu Gln Pro Lys Ala Ser
        1795                1800                1805            
Gln Ser Arg Lys Arg Ser Leu Ala Thr Met Asp Ser Pro Pro His Gln
    1810                1815                1820                
Lys Gln Pro Gln Arg Gly Glu Val Ser Gln Lys Thr Val Ile Ile Lys
1825                1830                1835                1840
Glu Glu Glu Glu Asp Thr Ala Glu Lys Pro Gly Lys Glu Glu Asp Val
                1845                1850                1855    
Val Thr Pro Lys Pro Gly Lys Arg Lys Arg Asp Gln Ala Glu Glu Glu
            1860                1865                1870        
Pro Asn Arg Ile Pro Ser Arg Ser Leu Arg Arg Thr Lys Leu Asn Gln
        1875                1880                1885            
Glu Ser Thr Ala Pro Lys Val Leu Phe Thr Gly Val Val Asp Ala Arg
    1890                1895                1900                
Gly Glu Arg Ala Val Leu Ala Leu Gly Gly Ser Leu Ala Gly Ser Ala
1905                1910                1915                1920
Ala Glu Ala Ser His Leu Val Thr Asp Arg Ile Arg Arg Thr Val Lys
                1925                1930                1935    
Phe Leu Cys Ala Leu Gly Arg Gly Ile Pro Ile Leu Ser Leu Asp Trp
            1940                1945                1950        
Leu His Gln Ser Arg Lys Ala Gly Phe Phe Leu Pro Pro Asp Glu Tyr
        1955                1960                1965            
Val Val Thr Asp Pro Glu Gln Glu Lys Asn Phe Gly Phe Ser Leu Gln
    1970                1975                1980                
Asp Ala Leu Ser Arg Ala Arg Glu Arg Arg Leu Leu Glu Gly Tyr Glu
1985                1990                1995                2000
Ile Tyr Val Thr Pro Gly Val Gln Pro Pro Pro Pro Gln Met Gly Glu
                2005                2010                2015    
Ile Ile Ser Cys Cys Gly Gly Thr Tyr Leu Pro Ser Met Pro Arg Ser
            2020                2025                2030        
Tyr Lys Pro Gln Arg Val Val Ile Thr Cys Pro Gln Asp Phe Pro His
        2035                2040                2045            
Cys Ser Ile Pro Leu Arg Val Gly Leu Pro Leu Leu Ser Pro Glu Phe
    2050                2055                2060                
Leu Leu Thr Gly Val Leu Lys Gln Glu Ala Lys Pro Glu Ala Phe Val
2065                2070                2075                2080
Leu Ser Pro Leu Glu Met Ser Ser Thr
                2085                


<210> 7983
<211> 281
<212> PRT
<213> Homo sapiens

<400> 7983
Met Ala Gln Ser Gly Leu Thr Ala Thr Ser Ala Ser Gln Val Gln Ala
 1               5                  10                  15      
Ile Leu Leu Pro Gln Pro Ala Ser Val Arg His Tyr Ala Trp Val Val
            20                  25                  30          
Asp Gln Ile Asp Thr Leu Thr Ser Asp Leu Gln Leu Glu Asp Glu Met
        35                  40                  45              
Thr Asp Ser Ser Lys Thr Asp Thr Leu Asn Ser Ser Ser Ser Gly Thr
    50                  55                  60                  
Thr Ala Ser Ser Leu Glu Lys Ile Lys Val Gln Ala Asn Ala Pro Leu
65                  70                  75                  80  
Ile Lys Pro Pro Ala His Pro Ser Ala Ile Leu Thr Val Leu Arg Lys
                85                  90                  95      
Pro Asn Pro Pro Pro Pro Pro Pro Arg Leu Thr Pro Val Lys Cys Glu
            100                 105                 110         
Asp Pro Lys Arg Val Val Pro Thr Ala Asn Pro Val Lys Thr Asn Gly
        115                 120                 125             
Thr Leu Leu Arg Asn Gly Gly Leu Pro Gly Gly Pro Asn Lys Ile Pro
    130                 135                 140                 
Asn Gly Asp Ile Cys Cys Ile Pro Asn Ser Asn Leu Asp Lys Ala Pro
145                 150                 155                 160 
Val Gln Leu Leu Met His Arg Pro Glu Lys Asp Arg Cys Pro Gln Ala
                165                 170                 175     
Gly Pro Arg Glu Arg Val Arg Phe Asn Glu Lys Val Gln Tyr His Gly
            180                 185                 190         
Tyr Cys Pro Asp Cys Asp Thr Arg Tyr Asn Ile Lys Asn Arg Glu Val
        195                 200                 205             
His Leu His Ser Glu Pro Val His Pro Pro Gly Lys Ile Pro His Gln
    210                 215                 220                 
Gly Pro Pro Leu Pro Pro Thr Pro His Leu Pro Pro Phe Pro Leu Glu
225                 230                 235                 240 
Asn Gly Gly Met Gly Ile Ser His Ser Asn Ser Phe Pro Pro Ile Arg
                245                 250                 255     
Pro Ala Thr Val Pro Pro Pro Thr Ala Pro Lys Pro Gln Lys Thr Ile
            260                 265                 270         
Leu Arg Lys Ser Thr Thr Thr Thr Val
        275                 280     


<210> 7984
<211> 558
<212> PRT
<213> Homo sapiens

<400> 7984
Met Glu Ala Ala Ala Gln Phe Phe Val Glu Ser Pro Asp Val Val Tyr
 1               5                  10                  15      
Gly Pro Glu Ala Ile Glu Ala Gln Tyr Glu Tyr Arg Thr Thr Arg Val
            20                  25                  30          
Ser Arg Glu Gly Gly Val Leu Lys Val His Pro Thr Ser Thr Arg Phe
        35                  40                  45              
Thr Phe Arg Thr Ala Arg Gln Val Pro Arg Leu Gly Val Met Leu Val
    50                  55                  60                  
Gly Trp Gly Gly Asn Asn Gly Ser Thr Leu Thr Ala Ala Val Leu Ala
65                  70                  75                  80  
Asn Arg Leu Arg Leu Ser Trp Pro Thr Arg Ser Gly Arg Lys Glu Ala
                85                  90                  95      
Asn Tyr Tyr Gly Ser Leu Thr Gln Ala Gly Thr Val Ser Leu Gly Leu
            100                 105                 110         
Asp Ala Glu Gly Gln Glu Val Phe Val Pro Phe Ser Ala Val Leu Pro
        115                 120                 125             
Met Val Ala Pro Asn Asp Leu Val Phe Asp Gly Trp Asp Ile Ser Ser
    130                 135                 140                 
Leu Asn Leu Ala Glu Ala Met Arg Arg Ala Lys Val Leu Asp Trp Gly
145                 150                 155                 160 
Leu Gln Glu Gln Leu Trp Pro His Met Glu Ala Leu Arg Pro Arg Pro
                165                 170                 175     
Ser Val Tyr Ile Pro Glu Phe Ile Ala Ala Asn Gln Ser Ala Arg Ala
            180                 185                 190         
Asp Asn Leu Ile Pro Gly Ser Arg Ala Gln Gln Leu Glu Gln Ile Arg
        195                 200                 205             
Arg Asp Ile Arg Asp Phe Arg Ser Ser Ala Gly Leu Asp Lys Val Ile
    210                 215                 220                 
Val Leu Trp Thr Ala Asn Thr Glu Arg Phe Cys Glu Val Ile Pro Gly
225                 230                 235                 240 
Leu Asn Asp Thr Ala Glu Asn Leu Leu Arg Thr Ile Glu Leu Gly Leu
                245                 250                 255     
Glu Val Ser Pro Ser Thr Leu Phe Ala Val Ala Ser Ile Leu Glu Gly
            260                 265                 270         
Cys Ala Phe Leu Asn Gly Ser Pro Gln Asn Thr Leu Val Pro Gly Ala
        275                 280                 285             
Leu Glu Leu Ala Trp Gln His Arg Val Phe Val Gly Gly Asp Asp Phe
    290                 295                 300                 
Lys Ser Gly Gln Thr Lys Val Lys Ser Val Leu Val Asp Phe Leu Ile
305                 310                 315                 320 
Gly Ser Gly Leu Lys Thr Met Ser Ile Val Ser Tyr Asn His Leu Gly
                325                 330                 335     
Asn Asn Asp Gly Glu Asn Leu Ser Ala Pro Leu Gln Phe Arg Ser Lys
            340                 345                 350         
Glu Val Ser Lys Ser Asn Val Val Asp Asp Met Val Gln Ser Asn Pro
        355                 360                 365             
Val Leu Tyr Thr Pro Gly Glu Glu Pro Asp His Cys Val Val Ile Lys
    370                 375                 380                 
Tyr Val Pro Tyr Val Gly Asp Ser Lys Arg Ala Leu Asp Glu Tyr Thr
385                 390                 395                 400 
Ser Glu Leu Met Leu Gly Gly Thr Asn Thr Leu Val Leu His Asn Thr
                405                 410                 415     
Cys Glu Asp Ser Leu Leu Ala Ala Pro Ile Met Leu Asp Leu Ala Leu
            420                 425                 430         
Leu Thr Glu Leu Cys Gln Arg Val Ser Phe Cys Thr Asp Met Asp Pro
        435                 440                 445             
Glu Pro Gln Thr Phe His Pro Val Leu Ser Leu Leu Ser Phe Leu Phe
    450                 455                 460                 
Lys Ala Pro Leu Val Pro Pro Gly Ser Pro Val Val Asn Ala Leu Phe
465                 470                 475                 480 
Arg Gln Arg Ser Cys Ile Glu Asn Ile Leu Arg Ala Cys Val Gly Leu
                485                 490                 495     
Pro Pro Gln Asn His Met Leu Leu Glu His Lys Met Glu Arg Pro Gly
            500                 505                 510         
Pro Ser Leu Lys Arg Val Gly Pro Val Ala Ala Thr Tyr Pro Met Leu
        515                 520                 525             
Asn Lys Lys Gly Pro Val Pro Ala Ala Thr Asn Gly Cys Thr Gly Asp
    530                 535                 540                 
Ala Asn Gly His Leu Gln Glu Glu Pro Pro Met Pro Thr Thr
545                 550                 555             


<210> 7985
<211> 430
<212> PRT
<213> Homo sapiens

<400> 7985
Met Val Ala Pro Asn Asp Leu Val Phe Asp Gly Trp Asp Ile Ser Ser
 1               5                  10                  15      
Leu Asn Leu Ala Glu Ala Met Arg Arg Ala Lys Val Leu Asp Trp Gly
            20                  25                  30          
Leu Gln Glu Gln Leu Trp Pro His Met Glu Ala Leu Arg Pro Arg Pro
        35                  40                  45              
Ser Val Tyr Ile Pro Glu Phe Ile Ala Ala Asn Gln Ser Ala Arg Ala
    50                  55                  60                  
Asp Asn Leu Ile Pro Gly Ser Arg Ala Gln Gln Leu Glu Gln Ile Arg
65                  70                  75                  80  
Arg Asp Ile Arg Asp Phe Arg Ser Ser Ala Gly Leu Asp Lys Val Ile
                85                  90                  95      
Val Leu Trp Thr Ala Asn Thr Glu Arg Phe Cys Glu Val Ile Pro Gly
            100                 105                 110         
Leu Asn Asp Thr Ala Glu Asn Leu Leu Arg Thr Ile Glu Leu Gly Leu
        115                 120                 125             
Glu Val Ser Pro Ser Thr Leu Phe Ala Val Ala Ser Ile Leu Glu Gly
    130                 135                 140                 
Cys Ala Phe Leu Asn Gly Ser Pro Gln Asn Thr Leu Val Pro Gly Ala
145                 150                 155                 160 
Leu Glu Leu Ala Trp Gln His Arg Val Phe Val Gly Gly Asp Asp Phe
                165                 170                 175     
Lys Ser Gly Gln Thr Lys Val Lys Ser Val Leu Val Asp Phe Leu Ile
            180                 185                 190         
Gly Ser Gly Leu Lys Thr Met Ser Ile Val Ser Tyr Asn His Leu Gly
        195                 200                 205             
Asn Asn Asp Gly Glu Asn Leu Ser Ala Pro Leu Gln Phe Arg Ser Lys
    210                 215                 220                 
Glu Val Ser Lys Ser Asn Val Val Asp Asp Met Val Gln Ser Asn Pro
225                 230                 235                 240 
Val Leu Tyr Thr Pro Gly Glu Glu Pro Asp His Cys Val Val Ile Lys
                245                 250                 255     
Tyr Val Pro Tyr Val Gly Asp Ser Lys Arg Ala Leu Asp Glu Tyr Thr
            260                 265                 270         
Ser Glu Leu Met Leu Gly Gly Thr Asn Thr Leu Val Leu His Asn Thr
        275                 280                 285             
Cys Glu Asp Ser Leu Leu Ala Ala Pro Ile Met Leu Asp Leu Ala Leu
    290                 295                 300                 
Leu Thr Glu Leu Cys Gln Arg Val Ser Phe Cys Thr Asp Met Asp Pro
305                 310                 315                 320 
Glu Pro Gln Thr Phe His Pro Val Leu Ser Leu Leu Ser Phe Leu Phe
                325                 330                 335     
Lys Ala Pro Leu Val Pro Pro Gly Ser Pro Val Val Asn Ala Leu Phe
            340                 345                 350         
Arg Gln Arg Ser Cys Ile Glu Asn Ile Leu Arg Ala Cys Val Gly Leu
        355                 360                 365             
Pro Pro Gln Asn His Met Leu Leu Glu His Lys Met Glu Arg Pro Gly
    370                 375                 380                 
Pro Ser Leu Lys Arg Val Gly Pro Val Ala Ala Thr Tyr Pro Met Leu
385                 390                 395                 400 
Asn Lys Lys Gly Pro Val Pro Ala Ala Thr Asn Gly Cys Thr Gly Asp
                405                 410                 415     
Ala Asn Gly His Leu Gln Glu Glu Pro Pro Met Pro Thr Thr
            420                 425                 430 


<210> 7986
<211> 526
<212> PRT
<213> Homo sapiens

<400> 7986
Met Glu Ala Ala Ala Gln Phe Phe Val Glu Ser Pro Asp Val Val Tyr
 1               5                  10                  15      
Ser Pro Glu Ala Ile Glu Ala Gln Tyr Glu Tyr Arg Thr Thr Arg Val
            20                  25                  30          
Ser Arg Lys Gly Gly Val Leu Lys Val His Pro Thr Ser Thr Arg Phe
        35                  40                  45              
Thr Phe Arg Thr Ala Arg Gln Val Thr Arg Leu Gly Val Met Leu Val
    50                  55                  60                  
Gly Trp Gly Gly Asn Asn Gly Ser Thr Leu Thr Ala Ala Val Leu Ala
65                  70                  75                  80  
Asn Gln Thr Ala Leu Ser Trp Pro Thr Arg Gly Arg Lys Glu Ala Asn
                85                  90                  95      
Tyr Tyr Gly Ser Leu Thr Gln Ala Gly Thr Val Ser Leu Gly Leu Asp
            100                 105                 110         
Ala Glu Gly Gln Glu Val Phe Val Pro Phe Ser Ala Val Leu Pro Met
        115                 120                 125             
Val Ala Pro Asn Asp Leu Val Phe Asp Gly Trp Asp Ile Ser Ser Leu
    130                 135                 140                 
Asn Leu Ala Glu Ala Met Arg Arg Ala Lys Val Leu Asp Trp Gly Leu
145                 150                 155                 160 
Gln Glu Gln Leu Trp Pro His Met Glu Ala Leu Arg Pro Arg Pro Ser
                165                 170                 175     
Val Tyr Ile Pro Glu Phe Ile Ala Ala Asn Gln Ser Ala Arg Ala Asn
            180                 185                 190         
Asn Leu Ile Pro Gly Ser Arg Ala Gln Gln Leu Glu Gln Ile Arg Arg
        195                 200                 205             
Asp Ile Arg Asp Phe Arg Ser Ser Ala Gly Leu Asp Lys Val Ile Val
    210                 215                 220                 
Leu Trp Thr Ala Asn Thr Glu Arg Phe Cys Glu Val Ile Pro Gly Leu
225                 230                 235                 240 
Asn Asp Thr Ala Glu Asn Leu Leu Arg Thr Ile Glu Leu Gly Leu Glu
                245                 250                 255     
Val Ser Pro Ser Thr Leu Phe Ala Val Ala Ser Ile Leu Glu Gly Cys
            260                 265                 270         
Ala Phe Leu Asn Gly Ser Pro Gln Asn Thr Leu Val Pro Gly Ala Leu
        275                 280                 285             
Glu Leu Ala Trp Gln His Arg Val Phe Val Gly Gly Asp Asp Phe Lys
    290                 295                 300                 
Ser Gly Gln Thr Lys Val Lys Ser Val Leu Val Asp Phe Leu Ile Gly
305                 310                 315                 320 
Ser Gly Leu Lys Thr Met Ser Ile Val Ser Tyr Asn His Leu Gly Asn
                325                 330                 335     
Asn Asp Gly Glu Asn Leu Ser Ala Pro Leu Gln Phe Arg Ser Lys Glu
            340                 345                 350         
Val Ser Lys Ser Asn Val Val Asp Asp Met Val Gln Ser Asn Pro Val
        355                 360                 365             
Leu Tyr Thr Pro Gly Glu Glu Pro Asp His Cys Val Val Ile Lys Tyr
    370                 375                 380                 
Val Pro Tyr Val Gly Asp Ser Lys Arg Ala Leu Asp Glu Tyr Thr Ser
385                 390                 395                 400 
Glu Leu Met Leu Gly Gly Thr Asn Thr Leu Val Leu His Asn Thr Cys
                405                 410                 415     
Glu Asp Ser Leu Leu Ala Ala Pro Ile Met Leu Asp Leu Ala Leu Leu
            420                 425                 430         
Thr Glu Leu Cys Gln Arg Val Ser Phe Cys Thr Asp Met Asp Pro Glu
        435                 440                 445             
Pro Gln Thr Phe His Pro Val Leu Ser Leu Leu Ser Phe Leu Phe Lys
    450                 455                 460                 
Ala Pro Leu Val Pro Pro Gly Ser Pro Val Val Asn Ala Leu Phe Arg
465                 470                 475                 480 
Gln Arg Ser Cys Ile Glu Asn Ile Leu Arg Ala Cys Val Gly Ser Arg
                485                 490                 495     
His Arg Thr Thr Cys Ser Trp Asn Thr Lys Trp Ser Ala Gln Gly Pro
            500                 505                 510         
Ala Ser Ser Glu Leu Asp Pro Trp Leu Pro Pro Thr Leu Cys
        515                 520                 525     


<210> 7987
<211> 558
<212> PRT
<213> Homo sapiens

<400> 7987
Met Glu Ala Ala Ala Gln Phe Phe Val Glu Ser Pro Asp Val Val Tyr
 1               5                  10                  15      
Gly Pro Glu Ala Ile Glu Ala Gln Tyr Glu Tyr Arg Thr Thr Arg Val
            20                  25                  30          
Ser Arg Glu Gly Gly Val Leu Lys Val His Pro Thr Ser Thr Arg Phe
        35                  40                  45              
Thr Phe Arg Thr Ala Arg Gln Val Pro Arg Leu Gly Val Met Leu Val
    50                  55                  60                  
Gly Trp Gly Gly Asn Asn Gly Ser Thr Leu Thr Ala Ala Val Leu Ala
65                  70                  75                  80  
Asn Arg Leu Arg Leu Ser Trp Pro Thr Arg Ser Gly Arg Lys Glu Ala
                85                  90                  95      
Asn Tyr Tyr Gly Ser Leu Thr Gln Ala Gly Thr Val Ser Leu Gly Leu
            100                 105                 110         
Asp Ala Glu Gly Gln Glu Val Phe Val Pro Phe Ser Ala Val Leu Pro
        115                 120                 125             
Met Val Ala Pro Asn Asp Leu Val Phe Asp Gly Trp Asp Ile Ser Ser
    130                 135                 140                 
Leu Asn Leu Ala Glu Ala Met Arg Arg Ala Asn Val Leu Asp Trp Gly
145                 150                 155                 160 
Leu Gln Glu Gln Leu Trp Pro His Met Glu Ala Leu Arg Pro Arg Pro
                165                 170                 175     
Ser Val Tyr Ile Pro Glu Phe Ile Ala Ala Asn Gln Ser Ala Arg Ala
            180                 185                 190         
Asp Asn Leu Ile Pro Gly Ser Arg Ala Gln Gln Leu Glu Gln Ile Arg
        195                 200                 205             
Arg Asp Ile Arg Asp Phe Arg Ser Ser Ala Gly Leu Asp Lys Val Ile
    210                 215                 220                 
Val Leu Trp Thr Ala Asn Thr Glu Arg Phe Cys Glu Val Ile Pro Gly
225                 230                 235                 240 
Leu Asn Asp Thr Ala Glu Asn Leu Leu Arg Thr Ile Glu Leu Gly Leu
                245                 250                 255     
Glu Val Ser Pro Ser Thr Leu Phe Ala Val Ala Ser Ile Leu Glu Gly
            260                 265                 270         
Cys Ala Phe Leu Asn Gly Ser Pro Gln Asn Thr Leu Val Pro Gly Ala
        275                 280                 285             
Leu Glu Leu Ala Trp Gln His Arg Val Phe Val Gly Gly Asp Asp Phe
    290                 295                 300                 
Lys Ser Gly Gln Thr Lys Val Lys Ser Val Leu Val Asp Phe Leu Ile
305                 310                 315                 320 
Gly Ser Gly Leu Lys Thr Met Ser Ile Val Ser Tyr Asn His Leu Gly
                325                 330                 335     
Asn Asn Asp Gly Glu Asn Leu Ser Ala Pro Leu Gln Phe Arg Ser Lys
            340                 345                 350         
Glu Val Ser Lys Ser Asn Val Val Asp Asp Met Val Gln Ser Asn Pro
        355                 360                 365             
Val Leu Tyr Thr Pro Gly Glu Glu Pro Asp His Cys Val Val Ile Lys
    370                 375                 380                 
Tyr Val Pro Tyr Val Gly Asp Ser Lys Arg Ala Leu Asp Glu Tyr Thr
385                 390                 395                 400 
Ser Glu Leu Met Leu Gly Gly Thr Asn Thr Leu Val Leu His Asn Thr
                405                 410                 415     
Cys Glu Asp Ser Leu Leu Ala Ala Pro Ile Met Leu Asp Leu Ala Leu
            420                 425                 430         
Leu Thr Glu Leu Cys Gln Arg Val Ser Phe Cys Thr Asp Met Asp Pro
        435                 440                 445             
Glu Pro Gln Thr Phe His Pro Val Leu Ser Leu Leu Ser Phe Leu Phe
    450                 455                 460                 
Lys Ala Pro Leu Val Pro Pro Gly Ser Pro Val Val Asn Ala Leu Phe
465                 470                 475                 480 
Arg Gln Arg Ser Cys Ile Glu Asn Ile Leu Arg Ala Cys Val Gly Leu
                485                 490                 495     
Pro Pro Gln Asn His Met Leu Leu Glu His Lys Met Glu Arg Pro Gly
            500                 505                 510         
Pro Ser Leu Lys Arg Val Gly Pro Val Ala Ala Thr Tyr Pro Met Leu
        515                 520                 525             
Asn Lys Lys Gly Pro Val Pro Ala Ala Thr Asn Gly Cys Thr Gly Asp
    530                 535                 540                 
Ala Asn Gly His Leu Gln Glu Glu Pro Pro Met Pro Thr Thr
545                 550                 555             


<210> 7988
<211> 162
<212> PRT
<213> Homo sapiens

<400> 7988
Arg Gly Pro Ala Pro Pro Arg Thr Leu Pro Ser Thr Glu Leu Gly Ala
 1               5                  10                  15      
Ala Gly Leu Gln Ser Pro Ser Gly Leu Arg Ser Trp Arg Ser Arg Gly
            20                  25                  30          
Pro Arg Pro Glu Leu Ala Pro Glu Gln Phe Val Ile Tyr Gln Val Gly
        35                  40                  45              
Leu Ile Pro Ser Gln Tyr Tyr Gly Val Leu Gly Asn Lys Asp Leu Glu
    50                  55                  60                  
Gly Phe Lys Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn
65                  70                  75                  80  
Ser Thr Gly Pro Ala His Gln Pro Gly Arg Gly Ala Ile Leu Pro Ala
                85                  90                  95      
Ala Gln Gln His Gly Gln Gln Ala His His Leu Pro Val His Pro Arg
            100                 105                 110         
Leu Leu His Leu Pro Val Leu Pro Lys His Arg Leu Ala Arg Ala Cys
        115                 120                 125             
Glu His Leu Arg Val Phe His Pro Gly Asp Arg Gly Glu Gln Asn Phe
    130                 135                 140                 
Asp Gly Pro His Cys Asp Glu Ala Gly Ala Ser Gly Glu Ala Gly Gly
145                 150                 155                 160 
Arg Phe
        


<210> 7989
<211> 515
<212> PRT
<213> Homo sapiens

<400> 7989
Met Pro Asn Thr Asn Gly Ser Ile Gly His Ser Pro Leu Ser Leu Ser
 1               5                  10                  15      
Ala Gln Ser Val Met Glu Glu Leu Asn Thr Ala Pro Val Gln Glu Ser
            20                  25                  30          
Pro Pro Leu Ala Met Pro Pro Gly Asn Ser His Gly Leu Glu Val Gly
        35                  40                  45              
Ser Leu Ala Glu Val Lys Glu Asn Pro Pro Phe Tyr Gly Val Ile Arg
    50                  55                  60                  
Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu Val Leu Ala Gly Leu Glu
65                  70                  75                  80  
Leu Glu Asp Glu Cys Ala Gly Cys Thr Asp Gly Thr Phe Arg Gly Thr
                85                  90                  95      
Arg Tyr Phe Thr Cys Ala Leu Lys Lys Ala Leu Phe Val Lys Leu Lys
            100                 105                 110         
Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser Leu Gln Pro Val Ser Asn
        115                 120                 125             
Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe Gly Gly Tyr Leu Ser Glu
    130                 135                 140                 
Val Val Glu Glu Asn Thr Pro Pro Lys Met Glu Lys Glu Gly Leu Glu
145                 150                 155                 160 
Ile Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys
                165                 170                 175     
Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu
            180                 185                 190         
Asp Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr
        195                 200                 205             
Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg
    210                 215                 220                 
Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile
225                 230                 235                 240 
Leu Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp
                245                 250                 255     
Pro Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu
            260                 265                 270         
Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr
        275                 280                 285             
Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr
    290                 295                 300                 
Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe
305                 310                 315                 320 
Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys
                325                 330                 335     
Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Ile Tyr
            340                 345                 350         
Gln Ile Tyr Leu Lys Thr Leu Pro Asp Ser Ala Gly Tyr Val Glu Gly
        355                 360                 365             
Leu Gln Cys Met Ser Val Glu Asn Ala Thr Thr Ile Arg Thr Phe Ser
    370                 375                 380                 
Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr Gln Val His
385                 390                 395                 400 
Leu His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro
                405                 410                 415     
Lys Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln
            420                 425                 430         
Asn Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val
        435                 440                 445             
Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp
    450                 455                 460                 
Ser Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln
465                 470                 475                 480 
Val Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu
                485                 490                 495     
Asp Leu His Ser Leu Asp Ser Arg Arg Ile Pro Arg Leu Cys Thr Lys
            500                 505                 510         
Thr Ala Leu
        515 


<210> 7990
<211> 1883
<212> PRT
<213> Homo sapiens

<400> 7990
Met Pro Val Gly Arg Ile Glu Cys Pro Ser Ser Pro Ser Phe Pro Arg
 1               5                  10                  15      
Asp Ile Ser His Glu Cys Arg Val Cys Gly Val Thr Glu Val Gly Leu
            20                  25                  30          
Ser Ala Tyr Ala Lys His Ile Ser Gly Gln Leu His Lys Asp Asn Val
        35                  40                  45              
Asp Ala Gln Glu Arg Glu Asp Asp Gly Lys Gly Glu Glu Glu Glu Glu
    50                  55                  60                  
Asp Tyr Phe Asp Lys Glu Leu Ile Gln Leu Ile Lys Gln Arg Lys Glu
65                  70                  75                  80  
Gln Ser Arg Gln Asp Glu Pro Ser Asn Ser Asn Gln Glu Ile Asn Ser
                85                  90                  95      
Asp Asp Arg Arg Pro Gln Trp Arg Arg Glu Asp Arg Ile Pro Tyr Gln
            100                 105                 110         
Asp Arg Glu Ser Tyr Ser Gln Pro Ala Trp His His Arg Gly Pro Pro
        115                 120                 125             
Gln Arg Asp Trp Lys Trp Glu Lys Asp Gly Phe Asn Asn Thr Arg Lys
    130                 135                 140                 
Asn Ser Phe Pro His Ser Leu Arg Asn Gly Gly Gly Pro Arg Gly Arg
145                 150                 155                 160 
Ser Gly Trp His Lys Gly Val Ala Gly Gly Ser Ser Thr Trp Phe His
                165                 170                 175     
Asn His Ser Asn Ser Gly Gly Gly Trp Leu Ser Asn Ser Gly Ala Val
            180                 185                 190         
Asp Trp Asn His Asn Gly Thr Gly Arg Asn Ser Ser Trp Leu Ser Glu
        195                 200                 205             
Gly Thr Gly Gly Phe Ser Ser Trp His Met Asn Asn Ser Asn Gly Asn
    210                 215                 220                 
Trp Lys Ser Ser Val Arg Ser Thr Asn Asn Trp Asn Tyr Ser Gly Pro
225                 230                 235                 240 
Gly Asp Lys Phe Gln Pro Gly Arg Asn Arg Asn Ser Asn Cys Gln Met
                245                 250                 255     
Glu Asp Met Thr Met Leu Trp Asn Lys Lys Ser Asn Lys Ser Asn Lys
            260                 265                 270         
Tyr Ser His Asp Arg Tyr Asn Trp Gln Arg Gln Glu Asn Asp Lys Leu
        275                 280                 285             
Gly Thr Val Ala Thr Tyr Arg Gly Pro Ser Glu Gly Phe Thr Ser Asp
    290                 295                 300                 
Lys Phe Pro Ser Glu Gly Leu Leu Asp Phe Asn Phe Glu Gln Leu Glu
305                 310                 315                 320 
Ser Gln Thr Thr Lys Gln Ala Asp Thr Ala Thr Ser Lys Val Ser Gly
                325                 330                 335     
Lys Asn Gly Ser Ala Ala Arg Glu Lys Pro Arg Arg Trp Thr Pro Tyr
            340                 345                 350         
Pro Ser Gln Lys Thr Leu Asp Leu Gln Ser Gly Leu Lys Asp Ile Thr
        355                 360                 365             
Gly Asn Lys Ser Glu Met Ile Glu Lys Pro Leu Phe Asp Phe Ser Leu
    370                 375                 380                 
Ile Thr Thr Gly Ile Gln Glu Pro Gln Thr Asp Glu Thr Arg Asn Ser
385                 390                 395                 400 
Pro Thr Gln Lys Thr Gln Lys Glu Ile His Thr Gly Ser Leu Asn His
                405                 410                 415     
Lys Ala Ser Ser Asp Ser Ala Ala Ser Phe Glu Val Val Arg Gln Cys
            420                 425                 430         
Pro Thr Ala Glu Lys Pro Glu Gln Glu His Thr Pro Asn Lys Met Pro
        435                 440                 445             
Ser Leu Lys Ser Pro Leu Leu Pro Cys Pro Ala Thr Lys Ser Leu Ser
    450                 455                 460                 
Gln Lys Gln Asp Pro Lys Asn Ile Ser Lys Asn Thr Lys Thr Asn Phe
465                 470                 475                 480 
Phe Ser Pro Gly Glu His Ser Asn Pro Ser Asn Lys Pro Thr Val Glu
                485                 490                 495     
Asp Asn His Gly Pro Tyr Ile Ser Lys Leu Arg Ser Ser Cys Pro His
            500                 505                 510         
Val Leu Lys Gly Asn Lys Ser Thr Phe Gly Ser Gln Lys Gln Ser Gly
        515                 520                 525             
Asp Asn Leu Asn Asp Thr Leu Arg Lys Ala Lys Glu Val Leu Gln Cys
    530                 535                 540                 
His Glu Ser Leu Gln Asn Pro Leu Leu Ser Thr Ser Lys Ser Thr Arg
545                 550                 555                 560 
Asn Tyr Ala Lys Ala Ser Arg Asn Val Glu Glu Ser Glu Lys Gly Ser
                565                 570                 575     
Leu Lys Ile Glu Phe Gln Val His Ala Leu Glu Asp Glu Ser Asp Gly
            580                 585                 590         
Glu Thr Ser Asp Thr Glu Lys His Gly Thr Lys Ile Gly Thr Leu Gly
        595                 600                 605             
Ser Ala Thr Thr Glu Leu Leu Ser Gly Ser Thr Arg Thr Ala Asp Glu
    610                 615                 620                 
Lys Glu Glu Asp Asp Arg Ile Leu Lys Thr Ser Arg Glu Leu Ser Thr
625                 630                 635                 640 
Ser Pro Cys Asn Pro Ile Val Arg Gln Lys Glu Ser Glu Leu Gln Met
                645                 650                 655     
Thr Ser Ala Ala Ser Pro His Pro Gly Leu Leu Leu Asp Leu Lys Thr
            660                 665                 670         
Ser Leu Glu Asp Ala Gln Val Asp Asp Ser Ile Lys Ser His Val Ser
        675                 680                 685             
Tyr Glu Thr Glu Gly Phe Glu Ser Ala Ser Leu Asp Ala Glu Leu Gln
    690                 695                 700                 
Lys Ser Asp Ile Ser Gln Pro Ser Gly Pro Leu Leu Pro Glu Leu Ser
705                 710                 715                 720 
Lys Leu Gly Phe Pro Ala Ser Leu Gln Arg Asp Leu Thr Arg His Ile
                725                 730                 735     
Ser Leu Lys Ser Lys Thr Gly Val His Leu Pro Glu Pro Asn Leu Asn
            740                 745                 750         
Ser Ala Arg Arg Ile Arg Asn Ile Ser Gly His Arg Lys Ser Glu Thr
        755                 760                 765             
Glu Lys Glu Ser Gly Leu Lys Pro Thr Leu Arg Gln Ile Leu Asn Ala
    770                 775                 780                 
Ser Arg Arg Asn Val Asn Trp Glu Gln Val Ile Gln Gln Val Thr Lys
785                 790                 795                 800 
Lys Lys Gln Glu Leu Gly Lys Gly Leu Pro Arg Phe Gly Ile Glu Met
                805                 810                 815     
Val Pro Leu Val Gln Asn Glu Gln Glu Ala Leu Asp Leu Asp Gly Glu
            820                 825                 830         
Pro Asp Leu Ser Ser Leu Glu Gly Phe Gln Trp Glu Gly Val Ser Ile
        835                 840                 845             
Ser Ser Ser Pro Gly Leu Ala Arg Lys Arg Ser Leu Ser Glu Ser Ser
    850                 855                 860                 
Val Ile Met Asp Arg Ala Pro Ser Val Tyr Ser Phe Phe Ser Glu Glu
865                 870                 875                 880 
Gly Thr Gly Lys Glu Asn Glu Pro Gln Gln Met Val Ser Pro Ser Asn
                885                 890                 895     
Ser Leu Arg Ala Gly Gln Ser Gln Lys Ala Thr Met His Leu Lys Gln
            900                 905                 910         
Glu Val Thr Pro Arg Ala Ala Ser Leu Arg Thr Gly Glu Arg Ala Glu
        915                 920                 925             
Asn Val Ala Thr Gln Arg Arg His Ser Ala Gln Leu Ser Ser Asp His
    930                 935                 940                 
Ile Ile Pro Leu Met His Leu Ala Lys Asp Leu Asn Ser Gln Glu Arg
945                 950                 955                 960 
Ser Ile Pro Pro Ser Glu Asn Gln Asn Ser Gln Glu Ser Asn Gly Glu
                965                 970                 975     
Gly Asn Cys Leu Ser Ser Ser Ala Ser Ser Ala Leu Ala Ile Ser Ser
            980                 985                 990         
Leu Ala Asp Ala Ala Thr Asp Ser Ser Cys Thr Ser Gly Ala Glu Gln
        995                 1000                1005            
Asn Asp Gly Gln Ser Ile Arg Lys Lys Arg Arg Ala Thr Gly Asp Gly
    1010                1015                1020                
Ser Ser Pro Glu Leu Pro Ser Leu Glu Arg Lys Asn Lys Arg Arg Lys
1025                1030                1035                1040
Ile Lys Gly Lys Lys Glu Arg Ser Gln Val Asp Gln Leu Leu Asn Ile
                1045                1050                1055    
Ser Leu Arg Glu Glu Glu Leu Ser Lys Ser Leu Gln Cys Met Asp Asn
            1060                1065                1070        
Asn Leu Leu Gln Ala Arg Ala Ala Leu Gln Thr Ala Tyr Val Glu Val
        1075                1080                1085            
Gln Arg Leu Leu Met Leu Lys Gln Gln Ile Thr Met Glu Met Ser Ala
    1090                1095                1100                
Leu Arg Thr His Arg Ile Gln Ile Leu Gln Gly Leu Gln Glu Thr Tyr
1105                1110                1115                1120
Glu Pro Ser Glu His Pro Asp Gln Val Pro Cys Ser Leu Thr Arg Glu
                1125                1130                1135    
Arg Arg Asn Ser Arg Ser Gln Thr Ser Ile Asp Ala Ala Leu Leu Pro
            1140                1145                1150        
Thr Pro Phe Phe Pro Leu Phe Leu Glu Pro Pro Ser Ser His Val Ser
        1155                1160                1165            
Pro Ser Pro Thr Gly Ala Ser Leu Gln Ile Thr Thr Ser Pro Thr Phe
    1170                1175                1180                
Gln Thr His Gly Ser Val Pro Ala Pro Asp Ser Ser Val Gln Ile Lys
1185                1190                1195                1200
Gln Glu Pro Met Ser Pro Glu Gln Asp Glu Asn Val Asn Ala Val Pro
                1205                1210                1215    
Pro Ser Ser Ala Cys Asn Val Ser Lys Glu Leu Leu Glu Ala Asn Arg
            1220                1225                1230        
Glu Ile Ser Asp Ser Cys Pro Val Tyr Pro Val Ile Thr Ala Arg Leu
        1235                1240                1245            
Ser Leu Pro Glu Ser Thr Glu Ser Phe His Glu Pro Ser Gln Glu Leu
    1250                1255                1260                
Lys Phe Ser Val Glu Gln Arg Asn Thr Arg Asn Arg Glu Asn Ser Pro
1265                1270                1275                1280
Ser Ser Gln Ser Ala Gly Leu Ser Ser Ile Asn Lys Glu Gly Glu Glu
                1285                1290                1295    
Pro Thr Lys Gly Asn Ser Gly Ser Glu Ala Cys Thr Ser Ser Phe Leu
            1300                1305                1310        
Arg Leu Ser Phe Ala Ser Glu Thr Pro Leu Glu Lys Glu Pro His Ser
        1315                1320                1325            
Pro Ala Asp Gln Pro Glu Gln Gln Ala Glu Ser Thr Leu Thr Ser Ala
    1330                1335                1340                
Glu Thr Arg Gly Ser Lys Lys Lys Lys Lys Leu Arg Lys Lys Lys Ser
1345                1350                1355                1360
Leu Arg Ala Ala His Val Pro Glu Asn Ser Asp Thr Glu Gln Asp Val
                1365                1370                1375    
Leu Thr Val Lys Pro Val Arg Lys Val Lys Ala Gly Lys Leu Ile Lys
            1380                1385                1390        
Gly Gly Lys Val Thr Thr Ser Thr Trp Glu Asp Ser Arg Thr Gly Arg
        1395                1400                1405            
Glu Gln Glu Ser Val Arg Asp Glu Pro Asp Ser Asp Ser Ser Leu Glu
    1410                1415                1420                
Val Leu Glu Ile Pro Asn Pro Gln Leu Glu Val Val Ala Ile Asp Ser
1425                1430                1435                1440
Ser Glu Ser Gly Glu Glu Lys Pro Asp Ser Pro Ser Lys Lys Asp Ile
                1445                1450                1455    
Trp Asn Ser Thr Glu Gln Asn Pro Leu Glu Thr Ser Arg Ser Gly Cys
            1460                1465                1470        
Asp Glu Val Ser Ser Thr Ser Glu Ile Gly Thr Arg Tyr Lys Asp Gly
        1475                1480                1485            
Ile Pro Val Ser Val Ala Glu Thr Gln Thr Val Ile Ser Ser Ile Lys
    1490                1495                1500                
Gly Ser Lys Asn Ser Ser Glu Ile Ser Ser Glu Pro Gly Asp Asp Asp
1505                1510                1515                1520
Glu Pro Thr Glu Gly Ser Phe Glu Gly His Gln Ala Ala Val Asn Ala
                1525                1530                1535    
Ile Gln Ile Phe Gly Asn Leu Leu Tyr Thr Cys Ser Ala Asp Lys Thr
            1540                1545                1550        
Val Arg Val Tyr Asn Leu Val Ser Arg Lys Cys Ile Gly Val Phe Glu
        1555                1560                1565            
Gly His Thr Ser Lys Val Asn Cys Leu Leu Val Thr Gln Thr Ser Gly
    1570                1575                1580                
Lys Asn Ala Ala Leu Tyr Thr Gly Ser Ser Asp His Thr Ile Arg Cys
1585                1590                1595                1600
Tyr Asn Val Lys Ser Arg Glu Cys Val Glu Gln Leu Gln Leu Glu Asp
                1605                1610                1615    
Arg Val Leu Cys Leu His Ser Arg Trp Arg Ile Leu Tyr Ala Gly Leu
            1620                1625                1630        
Ala Asn Gly Thr Val Val Thr Phe Asn Ile Lys Asn Asn Lys Arg Leu
        1635                1640                1645            
Glu Ile Phe Glu Cys His Gly Pro Arg Ala Val Ser Cys Leu Ala Thr
    1650                1655                1660                
Ala Gln Glu Gly Ala Arg Lys Leu Leu Val Val Gly Ser Tyr Asp Cys
1665                1670                1675                1680
Thr Ile Ser Val Arg Asp Ala Arg Asn Gly Leu Leu Leu Arg Thr Leu
                1685                1690                1695    
Glu Gly His Ser Lys Thr Ile Leu Cys Met Lys Val Val Asn Asp Leu
            1700                1705                1710        
Val Phe Ser Gly Ser Ser Asp Gln Ser Val His Ala His Asn Ile His
        1715                1720                1725            
Thr Gly Glu Leu Val Arg Ile Tyr Lys Gly His Asn His Ala Val Thr
    1730                1735                1740                
Val Val Asn Ile Leu Gly Lys Val Met Val Thr Ala Cys Leu Asp Lys
1745                1750                1755                1760
Phe Val Arg Val Tyr Glu Leu Gln Ser His Asp Arg Leu Gln Val Tyr
                1765                1770                1775    
Gly Gly His Lys Asp Met Ile Met Cys Met Thr Ile His Lys Ser Met
            1780                1785                1790        
Ile Tyr Thr Gly Cys Tyr Asp Gly Ser Ile Gln Ala Val Arg Leu Asn
        1795                1800                1805            
Leu Met Gln Asn Tyr Arg Cys Trp Trp His Gly Cys Ser Leu Ile Phe
    1810                1815                1820                
Gly Val Val Asp His Leu Lys Gln His Leu Leu Thr Asp His Thr Asn
1825                1830                1835                1840
Pro Asn Phe Gln Thr Leu Lys Cys Arg Trp Lys Asn Cys Asp Ala Phe
                1845                1850                1855    
Phe Thr Ala Arg Lys Gly Ser Lys Gln Asp Ala Ala Gly His Ile Glu
            1860                1865                1870        
Arg His Ala Glu Asp Asp Ser Lys Ile Asp Ser
        1875                1880            


<210> 7991
<211> 348
<212> PRT
<213> Homo sapiens

<400> 7991
Gly Tyr Cys Pro Ser Trp Ala Leu Asn Trp Glu Tyr Arg Lys Lys Gly
 1               5                  10                  15      
Ile Met Glu Glu Ile Val Asn Cys Asp Ala Asp Ile Ile Ser Leu Gln
            20                  25                  30          
Glu Val Glu Thr Glu Gln Tyr Phe Thr Leu Phe Leu Pro Ala Leu Lys
        35                  40                  45              
Glu Arg Gly Tyr Asp Gly Phe Phe Ser Pro Lys Ser Arg Ala Lys Ile
    50                  55                  60                  
Met Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe
65                  70                  75                  80  
Lys Thr Glu Lys Phe Thr Leu Val Gln Lys His Thr Val Glu Phe Asn
                85                  90                  95      
Gln Val Ala Met Ala Asn Ser Asp Gly Ser Glu Ala Met Leu Asn Arg
            100                 105                 110         
Val Met Thr Lys Asp Asn Ile Gly Val Ala Val Val Leu Glu Val His
        115                 120                 125             
Lys Glu Leu Phe Gly Ala Gly Met Lys Pro Ile His Ala Ala Asp Lys
    130                 135                 140                 
Gln Leu Leu Ile Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr
145                 150                 155                 160 
Ser Asp Val Lys Leu Ile Gln Thr Met Met Phe Val Ser Glu Val Lys
                165                 170                 175     
Asn Ile Leu Glu Lys Ala Ser Ser Arg Pro Gly Ser Pro Thr Ala Asp
            180                 185                 190         
Pro Asn Ser Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu Pro
        195                 200                 205             
Asp Ser Gly Val Val Glu Tyr Leu Ser Asn Gly Gly Val Ala Asp Asn
    210                 215                 220                 
His Lys Asp Phe Lys Glu Leu Arg Tyr Asn Glu Cys Leu Met Asn Phe
225                 230                 235                 240 
Ser Cys Asn Gly Lys Asn Gly Ser Ser Glu Gly Arg Ile Thr His Gly
                245                 250                 255     
Phe Gln Leu Lys Ser Ala Tyr Glu Asn Asn Leu Met Pro Tyr Thr Asn
            260                 265                 270         
Tyr Thr Phe Asp Phe Lys Gly Val Ile Asp Tyr Ile Phe Tyr Ser Lys
        275                 280                 285             
Thr His Met Asn Val Leu Gly Val Leu Gly Pro Leu Asp Pro Gln Trp
    290                 295                 300                 
Leu Val Glu Asn Asn Ile Thr Gly Cys Pro His Pro His Ile Pro Ser
305                 310                 315                 320 
Asp His Phe Ser Leu Leu Thr Gln Leu Glu Leu His Pro Pro Leu Leu
                325                 330                 335     
Pro Leu Val Asn Gly Val His Leu Pro Asn Arg Arg
            340                 345             


<210> 7992
<211> 483
<212> PRT
<213> Homo sapiens

<400> 7992
Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro Arg Arg Ile Tyr Thr
 1               5                  10                  15      
Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys Lys Ser His Trp Ala
            20                  25                  30          
Glu Leu Glu Ile Ser Gly Asn Cys Leu Leu Arg Val Leu Pro Tyr Glu
        35                  40                  45              
Leu Gly Gly Leu Phe Gln Leu Gln Thr Leu Gly Leu Lys Gly Asn Pro
    50                  55                  60                  
Leu Ser Gln Asp Ile Leu Asn Leu Tyr Gln Asp Pro Asp Gly Thr Arg
65                  70                  75                  80  
Asn Leu Leu Asn Phe Met Leu Asp Asn Leu Ala Val His Pro Glu Gln
                85                  90                  95      
Leu Pro Pro Arg Pro Trp Ile Thr Leu Lys Glu Arg Asp Gln Ile Leu
            100                 105                 110         
Pro Ser Ala Ser Phe Thr Val Ile Cys Tyr Asn Val Leu Cys Asp Lys
        115                 120                 125             
Tyr Ala Thr Arg Gln Leu Tyr Gly Tyr Cys Pro Ser Trp Ala Leu Asn
    130                 135                 140                 
Leu Glu Tyr Arg Lys Lys Gly Ile Met Glu Glu Ile Val Asn Cys Asp
145                 150                 155                 160 
Ala Asp Ile Ile Ser Leu Gln Glu Val Glu Thr Glu Gln Tyr Phe Thr
                165                 170                 175     
Leu Phe Leu Pro Ala Leu Lys Glu Arg Glu Tyr Asp Gly Phe Phe Ser
            180                 185                 190         
Pro Lys Ser Arg Ala Lys Ile Met Ser Glu Gln Glu Arg Lys His Val
        195                 200                 205             
Asp Gly Cys Ala Ile Phe Phe Lys Arg Glu Lys Phe Thr Leu Val Gln
    210                 215                 220                 
Lys His Ala Val Glu Phe Asn Gln Val Ala Met Ala Asn Ser Asp Gly
225                 230                 235                 240 
Ser Glu Ala Met Leu Asn Arg Val Met Thr Lys Asp Asn Ile Gly Val
                245                 250                 255     
Thr Val Val Leu Glu Val His Lys Glu Leu Phe Gly Ala Gly Met Lys
            260                 265                 270         
Pro Ile His Ala Ala Asp Lys Gln Leu Leu Ile Val Ala Asn Ala His
        275                 280                 285             
Met His Trp Asp Pro Glu Tyr Ser Asp Val Lys Leu Ile Gln Thr Met
    290                 295                 300                 
Met Phe Val Ser Glu Val Lys Thr Ile Leu Glu Lys Ala Ser Ser Arg
305                 310                 315                 320 
Ser Gly Ser Pro Thr Ala Asp Pro Asn Ser Ile Pro Leu Val Leu Cys
                325                 330                 335     
Ala Asp Leu Asn Ser Leu Pro Asp Ser Gly Val Val Glu Tyr Leu Ser
            340                 345                 350         
Asn Gly Gly Ile Ala Asp Asn His Lys Asp Phe Lys Glu Leu Arg Tyr
        355                 360                 365             
Asn Lys Cys Leu Met Asn Phe Ser Cys Asn Gly Lys Asn Gly Ser Ser
    370                 375                 380                 
Glu Gly Arg Ile Thr His Gly Phe Gln Leu Lys Ser Ala Tyr Glu Asn
385                 390                 395                 400 
Asn Leu Met Pro Tyr Thr Asn Tyr Thr Phe Asp Phe Lys Gly Val Ile
                405                 410                 415     
Asp Tyr Ile Phe Tyr Ser Lys Thr His Met Asn Val Leu Gly Val Leu
            420                 425                 430         
Gly Pro Leu Asp Pro Gln Trp Leu Val Glu Asn Asn Ile Thr Gly Cys
        435                 440                 445             
Pro His Pro His Ile Pro Ser Asp His Phe Ser Leu Leu Thr Gln Leu
    450                 455                 460                 
Glu Leu His Pro Pro Leu Leu Pro Leu Val Asn Gly Val His Leu Pro
465                 470                 475                 480 
Asn Arg Arg
            


<210> 7993
<211> 189
<212> PRT
<213> Homo sapiens

<400> 7993
Met Pro Gln Thr Val Ile Leu Pro Gly Pro Ala Pro Trp Gly Phe Arg
 1               5                  10                  15      
Leu Ser Gly Gly Ile Asp Phe Asn Gln Pro Leu Val Ile Thr Arg Ile
            20                  25                  30          
Thr Pro Gly Ser Lys Ala Ala Ala Ala Asn Leu Cys Pro Gly Asp Val
        35                  40                  45              
Ile Leu Ala Ile Asp Gly Phe Gly Thr Glu Ser Met Thr His Ala Asp
    50                  55                  60                  
Ala Gln Asp Arg Ile Lys Ala Ala Ala His Gln Leu Cys Leu Lys Ile
65                  70                  75                  80  
Asp Arg Gly Glu Thr His Leu Trp Ser Pro Gln Val Ser Glu Asp Gly
                85                  90                  95      
Lys Ala His Pro Phe Lys Ile Asn Leu Glu Ser Glu Pro Gln Glu Phe
            100                 105                 110         
Lys Pro Ile Gly Thr Ala His Asn Arg Arg Ala Gln Pro Phe Val Ala
        115                 120                 125             
Ala Ala Asn Ile Asp Asp Lys Arg Gln Val Val Ser Ala Ser Tyr Asn
    130                 135                 140                 
Ser Pro Ile Gly Leu Tyr Ser Thr Ser Asn Ile Gln Asp Ala Leu His
145                 150                 155                 160 
Gly Gln Leu Arg Gly Leu Ile Pro Ser Ser Pro Gln Lys Thr Gly Thr
                165                 170                 175     
Thr Leu Asn Thr Ser Ile Ile Phe Gly Pro Asn Leu Ser
            180                 185                 


<210> 7994
<211> 405
<212> PRT
<213> Homo sapiens

<400> 7994
Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe
 1               5                  10                  15      
Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro
            20                  25                  30          
Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser
        35                  40                  45              
Asp Ser Ala His Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser
    50                  55                  60                  
Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln
65                  70                  75                  80  
Lys Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val Ser Cys Tyr Phe
                85                  90                  95      
Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr Asp Tyr Thr Leu
            100                 105                 110         
Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe Pro Ile Cys Gln
        115                 120                 125             
Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr Thr Ile Glu Ser
    130                 135                 140                 
Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln Glu Ile Asn Phe
145                 150                 155                 160 
Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu Leu Phe Ser Lys
                165                 170                 175     
Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val Asn Ala Val Tyr
            180                 185                 190         
Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu Asn Thr Val Asp
        195                 200                 205             
Ala Pro Phe Cys Leu Asn Ala Asn Glu Asn Lys Ser Val Lys Met Met
    210                 215                 220                 
Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu Glu Val Lys Ala
225                 230                 235                 240 
Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu Ser Met Phe Val
                245                 250                 255     
Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly Leu Glu Glu Leu
            260                 265                 270         
Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp Ser Ser Ser Glu
        275                 280                 285             
Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro Arg Phe Thr Leu
    290                 295                 300                 
Glu Asp Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp Met Gly Ile Thr
305                 310                 315                 320 
Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly Ile Ser Pro Ser
                325                 330                 335     
Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr Phe Val Glu Val
            340                 345                 350         
Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly Ala Val Val Ser
        355                 360                 365             
Glu Arg Ser Leu Arg Ser Trp Val Glu Phe Asn Ala Asn His Pro Phe
    370                 375                 380                 
Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile Leu Phe Tyr Gly
385                 390                 395                 400 
Arg Val Cys Ser Pro
                405 


<210> 7995
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 7995
Met Ala Pro Gly Cys Lys Thr Glu Leu Arg Ser Val Thr Asn Gly Gln
 1               5                  10                  15      
Ser Asn Gln Pro Ser Asn Glu Gly Asp Ala Ile Lys Val Phe Val Arg
            20                  25                  30          
Ile Arg Pro Pro Ala Glu Arg Ser Gly Ser Ala Asp Gly Glu Gln Asn
        35                  40                  45              
Leu Cys Leu Ser Val Leu Ser Ser Thr Ser Leu Arg Leu His Ser Asn
    50                  55                  60                  
Pro Glu Pro Lys Thr Phe Thr Phe Asp His Val Ala Asp Val Asp Thr
65                  70                  75                  80  
Thr Gln Glu Ser Val Phe Ala Thr Val Ala Lys Ser Ile Val Glu Ser
                85                  90                  95      
Cys Met Ser Gly Tyr Asn Gly Thr Ile Phe Ala Tyr Gly Gln Thr Gly
            100                 105                 110         
Ser Gly Lys Thr Phe Thr Met Met Gly Pro Ser Glu Ser Asp Asn Phe
        115                 120                 125             
Ser His Asn Leu Arg Gly Val Ile Pro Arg Ser Phe Glu Tyr Leu Phe
    130                 135                 140                 
Ser Leu Ile Asp Arg Glu Lys Glu Lys Ala Gly Ala Gly Lys Ser Phe
145                 150                 155                 160 
Leu Cys Lys Cys Ser Phe Ile Glu Ile Tyr Asn Glu Gln Ile Tyr Asp
                165                 170                 175     
Leu Leu Asp Ser Ala Ser Ala Gly Leu Tyr Leu Arg Glu His Ile Lys
            180                 185                 190         
Lys Gly Val Phe Val Val Gly Ala Val Glu Gln Val Val Thr Ser Ala
        195                 200                 205             
Ala Glu Ala Tyr Gln Val Leu Ser Gly Gly Trp Arg Asn Arg Arg Val
    210                 215                 220                 
Ala Ser Thr Ser Met Asn Arg Glu Ser Ser Arg Ser His Ala Val Phe
225                 230                 235                 240 
Thr Ile Thr Ile Glu Ser Met Glu Lys Ser Asn Glu Ile Val Asn Ile
                245                 250                 255     
Arg Thr Ser Leu Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln
            260                 265                 270         
Lys Asp Thr His Ala Glu Gly Met Arg Leu Lys Glu Ala Gly Asn Ile
        275                 280                 285             
Asn Arg Ser Leu Ser Cys Leu Gly Gln Val Ile Thr Ala Leu Val Asp
    290                 295                 300                 
Val Gly Asn Gly Lys Gln Arg His Val Cys Tyr Arg Asp Ser Lys Leu
305                 310                 315                 320 
Thr Phe Leu Leu Arg Asp Ser Leu Gly Gly Asn Ala Lys Thr Ala Ile
                325                 330                 335     
Ile Ala Asn Val His Pro Gly Ser Arg Cys Phe Gly Glu Thr Leu Ser
            340                 345                 350         
Thr Leu Asn Phe Ala Gln Arg Ala Lys Leu Ile Lys Asn Lys Ala Val
        355                 360                 365             
Val Asn Glu Asp Thr Gln Gly Asn Val Ser Gln Leu Gln Ala Glu Val
    370                 375                 380                 
Lys Arg Leu Lys Glu Gln Leu Ala Glu Leu Ala Ser Gly Gln Thr Pro
385                 390                 395                 400 
Pro Glu Ser Phe Leu Thr Arg Asp Lys Lys Lys Thr Asn Tyr Met Glu
                405                 410                 415     
Tyr Phe Gln Glu Ala Met Leu Phe Phe Lys Lys Ser Glu Gln Glu Lys
            420                 425                 430         
Lys Ser Leu Ile Glu Lys Val Thr Gln Leu Glu Asp Leu Thr Leu Lys
        435                 440                 445             
Lys Glu Lys Phe Ile Gln Ser Asn Lys Met Ile Val Lys Phe Arg Glu
    450                 455                 460                 
Asp Gln Ile Ile Arg Leu Glu Lys Leu His Lys Glu Ser Arg Gly Gly
465                 470                 475                 480 
Phe Leu Pro Glu Glu Gln Asp Arg Leu Leu Ser Glu Leu Arg Asn Glu
                485                 490                 495     
Ile Gln Thr Leu Arg Glu Gln Ile Glu His His Pro Arg Val Ala Lys
            500                 505                 510         
Tyr Ala Met Glu Asn His Ser Leu Arg Glu Glu Asn Arg Arg Leu Arg
        515                 520                 525             
Leu Leu Glu Pro Val Lys Arg Ala Gln Glu Met Asp Ala Gln Thr Ile
    530                 535                 540                 
Ala Lys Leu Glu Lys Ala Phe Ser Glu Ile Ser Gly Met Glu Lys Ser
545                 550                 555                 560 
Asp Lys Asn Gln Gln Gly Phe Ser Pro Lys Ala Gln Lys Glu Pro Cys
                565                 570                 575     
Leu Phe Ala Asn Thr Glu Lys Leu Lys Ala Gln Leu Leu Gln Ile Gln
            580                 585                 590         
Thr Glu Leu Asn Asn Ser Lys Gln Glu Tyr Glu Glu Phe Lys Glu Leu
        595                 600                 605             
Thr Arg Lys Arg Gln Leu Glu Leu Glu Ser Glu Leu Gln Ser Leu Gln
    610                 615                 620                 
Lys Ala Asn Leu Asn Leu Glu Asn Leu Leu Glu Ala Thr Lys Ala Cys
625                 630                 635                 640 
Lys Arg Gln Glu Val Ser Gln Leu Asn Lys Ile His Ala Glu Thr Leu
                645                 650                 655     
Lys Ile Ile Thr Thr Pro Thr Lys Ala Tyr Gln Leu His Ser Arg Pro
            660                 665                 670         
Val Pro Lys Leu Ser Pro Glu Met Gly Ser Phe Gly Ser Leu Tyr Thr
        675                 680                 685             
Gln Asn Ser Ser Ile Leu Asp Asn Asp Ile Leu Asn Glu Pro Val Pro
    690                 695                 700                 
Pro Glu Met Asn Glu Gln Ala Phe Glu Ala Ile Ser Glu Glu Leu Arg
705                 710                 715                 720 
Thr Val Gln Glu Gln Met Ser Ala Leu Gln Ala Lys Leu Asp Glu Glu
                725                 730                 735     
Glu His Lys Asn Leu Lys Leu Gln Gln His Val Asp Lys Leu Glu His
            740                 745                 750         
His Ser Thr Gln Met Gln Glu Leu Phe Ser Ser Glu Arg Ile Asp Trp
        755                 760                 765             
Thr Lys Gln Gln Glu Glu Leu Leu Ser Gln Leu Asn Val Leu Glu Lys
    770                 775                 780                 
Gln Leu Gln Glu Thr Gln Thr Lys Asn Asp Phe Leu Lys Ser Glu Val
785                 790                 795                 800 
His Asp Leu Arg Val Val Leu His Ser Ala Asp Lys Glu Leu Ser Ser
                805                 810                 815     
Val Lys Leu Glu Tyr Ser Ser Phe Lys Thr Asn Gln Glu Lys Glu Phe
            820                 825                 830         
Asn Lys Leu Ser Glu Arg His Met His Val Gln Leu Gln Leu Asp Asn
        835                 840                 845             
Leu Arg Leu Glu Asn Glu Lys Leu Leu Glu Ser Lys Ala Cys Leu Gln
    850                 855                 860                 
Asp Ser Tyr Asp Asn Leu Gln Glu Ile Met Lys Phe Glu Ile Asp Gln
865                 870                 875                 880 
Leu Ser Arg Asn Leu Gln Asn Phe Lys Lys Glu Asn Glu Thr Leu Lys
                885                 890                 895     
Ser Asp Leu Asn Asn Leu Met Glu Leu Leu Glu Ala Glu Lys Glu Arg
            900                 905                 910         
Asn Asn Lys Leu Ser Leu Gln Phe Glu Glu Asp Lys Glu Asn Ser Ser
        915                 920                 925             
Lys Glu Ile Leu Lys Val Leu Glu Ala Val Arg Gln Glu Lys Gln Lys
    930                 935                 940                 
Glu Thr Ala Lys Cys Glu Gln Gln Met Ala Lys Val Gln Lys Leu Glu
945                 950                 955                 960 
Glu Ser Leu Leu Ala Thr Glu Lys Val Ile Ser Ser Leu Glu Lys Ser
                965                 970                 975     
Arg Asp Ser Asp Lys Lys Val Val Ala Asp Leu Met Asn Gln Ile Gln
            980                 985                 990         
Glu Leu Arg Thr Ser Val Cys Glu Lys Thr Glu Thr Ile Asp Thr Leu
        995                 1000                1005            
Lys Gln Glu Leu Lys Asp Ile Asn Cys Lys Tyr Asn Ser Ala Leu Val
    1010                1015                1020                
Asp Arg Glu Glu Ser Arg Val Leu Ile Lys Lys Gln Glu Val Asp Ile
1025                1030                1035                1040
Leu Asp Leu Lys Glu Thr Leu Arg Leu Arg Ile Leu Ser Glu Asp Ile
                1045                1050                1055    
Glu Arg Asp Met Leu Cys Glu Asp Leu Ala His Ala Thr Glu Gln Leu
            1060                1065                1070        
Asn Met Leu Thr Glu Ala Ser Lys Lys His Ser Gly Leu Leu Gln Ser
        1075                1080                1085            
Ala Gln Glu Glu Leu Thr Lys Lys Glu Ala Leu Ile Gln Glu Leu Gln
    1090                1095                1100                
His Lys Leu Asn Gln Lys Lys Glu Glu Val Glu Gln Lys Lys Asn Glu
1105                1110                1115                1120
Tyr Asn Phe Lys Met Arg Gln Leu Glu His Val Met Asp Ser Ala Ala
                1125                1130                1135    
Glu Asp Pro Gln Ser Pro Lys Thr Pro Pro His Phe Gln Thr His Leu
            1140                1145                1150        
Ala Lys Leu Leu Glu Thr Gln Glu Gln Glu Ile Glu Asp Gly Arg Ala
        1155                1160                1165            
Ser Lys Thr Ser Leu Glu His Leu Val Thr Lys Leu Asn Glu Asp Arg
    1170                1175                1180                
Glu Val Lys Asn Ala Glu Ile Leu Arg Met Lys Glu Gln Leu Arg Glu
1185                1190                1195                1200
Met Glu Asn Leu Arg Leu Glu Ser Gln Gln Leu Ile Glu Lys Asn Trp
                1205                1210                1215    
Leu Leu Gln Gly Gln Leu Asp Asp Ile Lys Arg Gln Lys Glu Asn Ser
            1220                1225                1230        
Asp Gln Asn His Pro Asp Asn Gln Gln Leu Lys Asn Glu Gln Glu Glu
        1235                1240                1245            
Ser Ile Lys Glu Arg Leu Ala Lys Ser Lys Ile Val Glu Glu Met Leu
    1250                1255                1260                
Lys Met Lys Ala Asp Leu Glu Glu Val Gln Ser Ala Leu Tyr Asn Lys
1265                1270                1275                1280
Glu Met Glu Cys Leu Arg Met Thr Asp Glu Val Glu Arg Thr Gln Thr
                1285                1290                1295    
Leu Glu Ser Lys Ala Phe Gln Glu Lys Glu Gln Leu Arg Ser Lys Leu
            1300                1305                1310        
Glu Glu Met Tyr Glu Glu Arg Glu Arg Thr Ser Gln Glu Met Glu Met
        1315                1320                1325            
Leu Arg Lys Gln Val Glu Cys Leu Ala Glu Glu Asn Gly Lys Leu Val
    1330                1335                1340                
Gly His Gln Asn Leu His Gln Lys Ile Gln Tyr Val Val Arg Leu Lys
1345                1350                1355                1360
Lys Glu Asn Val Arg Leu Ala Glu Glu Thr Glu Lys Leu Arg Ala Glu
                1365                1370                1375    
Asn Val Phe Leu Lys Glu Lys Lys Arg Ser Glu Ser
            1380                1385            


<210> 7996
<211> 576
<212> PRT
<213> Homo sapiens

<400> 7996
Met Glu Glu Ser His Phe Asn Ser Asn Pro Tyr Phe Trp Pro Ser Ile
 1               5                  10                  15      
Pro Thr Val Ser Gly Gln Ile Glu Asn Thr Met Phe Ile Asn Lys Met
            20                  25                  30          
Lys Asp Gln Leu Leu Pro Glu Lys Gly Cys Gly Leu Ala Pro Pro His
        35                  40                  45              
Tyr Pro Thr Leu Leu Thr Val Pro Ala Ser Val Ser Leu Pro Ser Gly
    50                  55                  60                  
Ile Ser Met Asp Thr Glu Ser Lys Ser Asp Gln Leu Thr Pro His Ser
65                  70                  75                  80  
Gln Ala Ser Val Thr Gln Asn Ile Thr Val Val Pro Val Pro Ser Thr
                85                  90                  95      
Gly Leu Met Thr Ala Gly Val Ser Cys Ser Gln Arg Trp Arg Arg Glu
            100                 105                 110         
Gly Ser Gln Ser Arg Gly Pro Gly Leu Val Ile Thr Ser Pro Ser Gly
        115                 120                 125             
Ser Leu Val Thr Thr Ala Ser Ser Ala Gln Thr Phe Pro Ile Ser Ala
    130                 135                 140                 
Pro Met Ile Val Ser Ala Leu Pro Pro Gly Ser Gln Ala Leu Gln Val
145                 150                 155                 160 
Val Pro Asp Leu Ser Lys Lys Val Ala Ser Thr Leu Thr Glu Glu Gly
                165                 170                 175     
Gly Gly Gly Gly Gly Gly Gly Gly Ser Val Ala Pro Lys Pro Pro Arg
            180                 185                 190         
Gly Arg Lys Lys Lys Arg Met Leu Glu Ser Gly Leu Pro Glu Met Asn
        195                 200                 205             
Asp Pro Tyr Val Leu Ser Pro Glu Asp Asp Asp Asp His Gln Lys Asp
    210                 215                 220                 
Gly Lys Thr Tyr Arg Cys Arg Met Cys Ser Leu Thr Phe Tyr Ser Lys
225                 230                 235                 240 
Ser Glu Met Gln Ile His Ser Lys Ser His Thr Glu Thr Lys Pro His
                245                 250                 255     
Lys Cys Pro His Cys Ser Lys Thr Phe Ala Asn Ser Ser Tyr Leu Ala
            260                 265                 270         
Gln His Ile Arg Ile His Ser Gly Ala Lys Pro Tyr Ser Cys Asn Phe
        275                 280                 285             
Cys Glu Lys Ser Phe Arg Gln Leu Ser His Leu Gln Gln His Thr Arg
    290                 295                 300                 
Ile His Ser Lys Met His Thr Glu Thr Ile Lys Pro His Lys Cys Pro
305                 310                 315                 320 
His Cys Ser Lys Thr Phe Ala Asn Thr Ser Tyr Leu Ala Gln His Leu
                325                 330                 335     
Arg Ile His Ser Gly Ala Lys Pro Tyr Asn Cys Ser Tyr Cys Gln Lys
            340                 345                 350         
Ala Phe Arg Gln Leu Ser His Leu Gln Gln His Thr Arg Ile His Thr
        355                 360                 365             
Gly Asp Arg Pro Tyr Lys Cys Ala His Pro Gly Cys Glu Lys Ala Phe
    370                 375                 380                 
Thr Gln Leu Ser Asn Leu Gln Ser His Arg Arg Gln His Asn Lys Asp
385                 390                 395                 400 
Lys Pro Phe Lys Cys His Asn Cys His Arg Ala Tyr Thr Asp Ala Ala
                405                 410                 415     
Ser Leu Glu Val His Leu Ser Thr His Thr Val Lys His Ala Lys Val
            420                 425                 430         
Tyr Thr Cys Thr Ile Cys Ser Arg Ala Tyr Thr Ser Glu Thr Tyr Leu
        435                 440                 445             
Met Lys His Met Arg Lys His Asn Pro Pro Asp Leu Gln Gln Gln Val
    450                 455                 460                 
Gln Ala Ala Ala Ala Ala Ala Ala Val Ala Gln Ala Gln Ala Gln Ala
465                 470                 475                 480 
Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala
                485                 490                 495     
Ser Gln Ala Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            500                 505                 510         
Gln Gln Gln Pro Pro Pro His Phe Gln Ser Pro Gly Ala Ala Pro Gln
        515                 520                 525             
Gly Gly Gly Gly Gly Asp Ser Asn Pro Asn Pro Pro Pro Gln Cys Ser
    530                 535                 540                 
Phe Asp Leu Thr Pro Tyr Lys Thr Ala Glu His His Lys Asp Ile Cys
545                 550                 555                 560 
Leu Thr Val Thr Thr Ser Thr Ile Gln Val Glu His Leu Ala Ser Ser
                565                 570                 575     


<210> 7997
<211> 515
<212> PRT
<213> Homo sapiens

<400> 7997
Met Glu Glu Ser His Phe Asn Ser Asn Pro Tyr Phe Trp Pro Ser Ile
 1               5                  10                  15      
Pro Thr Val Ser Gly Gln Ile Glu Asn Thr Met Phe Ile Asn Lys Met
            20                  25                  30          
Lys Asp Gln Leu Leu Pro Glu Lys Gly Cys Gly Leu Ala Pro Pro His
        35                  40                  45              
Tyr Pro Thr Leu Leu Thr Val Pro Ala Ser Val Ser Leu Pro Ser Gly
    50                  55                  60                  
Ile Ser Met Asp Thr Glu Ser Lys Ser Asp Gln Leu Thr Pro His Ser
65                  70                  75                  80  
Gln Ala Ser Val Thr Gln Asn Ile Thr Val Val Pro Val Pro Ser Thr
                85                  90                  95      
Gly Leu Met Thr Ala Gly Val Ser Cys Ser Gln Arg Trp Arg Arg Glu
            100                 105                 110         
Gly Ser Gln Ser Arg Gly Pro Gly Leu Val Ile Thr Ser Pro Ser Gly
        115                 120                 125             
Ser Leu Val Thr Thr Ala Ser Ser Ala Gln Thr Phe Pro Ile Ser Ala
    130                 135                 140                 
Pro Met Ile Val Ser Ala Leu Pro Pro Gly Ser Gln Ala Leu Gln Val
145                 150                 155                 160 
Val Pro Asp Leu Ser Lys Lys Val Ala Ser Thr Leu Thr Glu Glu Gly
                165                 170                 175     
Gly Gly Gly Gly Gly Gly Gly Gly Ser Val Ala Pro Lys Pro Pro Arg
            180                 185                 190         
Gly Arg Lys Lys Lys Arg Met Leu Glu Ser Gly Leu Pro Glu Met Asn
        195                 200                 205             
Asp Pro Tyr Val Leu Ser Pro Glu Asp Asp Asp Asp His Gln Lys Asp
    210                 215                 220                 
Gly Lys Thr Tyr Arg Cys Arg Met Cys Ser Leu Thr Phe Tyr Ser Lys
225                 230                 235                 240 
Ser Glu Met Gln Ile His Ser Lys Ser His Thr Glu Thr Lys Pro His
                245                 250                 255     
Lys Cys Pro His Cys Ser Lys Thr Phe Ala Asn Ser Ser Tyr Leu Ala
            260                 265                 270         
Gln His Ile Arg Ile His Ser Gly Ala Lys Pro Tyr Ser Cys Asn Phe
        275                 280                 285             
Cys Glu Lys Ser Phe Arg Gln Leu Ser His Leu Gln Gln His Thr Arg
    290                 295                 300                 
Ile His Thr Gly Asp Arg Pro Tyr Lys Cys Ala His Pro Gly Cys Glu
305                 310                 315                 320 
Lys Ala Phe Thr Gln Leu Ser Asn Leu Gln Ser His Arg Arg Gln His
                325                 330                 335     
Asn Lys Asp Lys Pro Phe Lys Cys His Asn Cys His Arg Ala Tyr Thr
            340                 345                 350         
Asp Ala Ala Ser Leu Glu Val His Leu Ser Thr His Thr Val Lys His
        355                 360                 365             
Ala Lys Val Tyr Thr Cys Thr Ile Cys Ser Arg Ala Tyr Thr Ser Glu
    370                 375                 380                 
Thr Tyr Leu Met Lys His Met Arg Lys His Asn Pro Pro Asp Leu Gln
385                 390                 395                 400 
Gln Gln Val Gln Ala Ala Ala Ala Ala Ala Ala Val Ala Gln Ala Gln
                405                 410                 415     
Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln
            420                 425                 430         
Ala Gln Ala Ser Gln Ala Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln
        435                 440                 445             
Gln Gln Gln Gln Gln Gln Pro Pro Pro His Phe Gln Ser Pro Gly Ala
    450                 455                 460                 
Ala Pro Gln Gly Gly Gly Gly Gly Asp Ser Asn Pro Asn Pro Pro Pro
465                 470                 475                 480 
Gln Cys Ser Phe Asp Leu Thr Pro Tyr Lys Thr Ala Glu His His Lys
                485                 490                 495     
Asp Ile Cys Leu Thr Val Thr Thr Ser Thr Ile Gln Val Glu His Leu
            500                 505                 510         
Ala Ser Ser
        515 


<210> 7998
<211> 460
<212> PRT
<213> Homo sapiens

<400> 7998
Met Glu Glu Ser His Phe Asn Ser Asn Pro Tyr Phe Trp Pro Ser Ile
 1               5                  10                  15      
Pro Thr Val Ser Gly Gln Ile Glu Asn Thr Met Phe Ile Asn Lys Met
            20                  25                  30          
Lys Asp Gln Leu Leu Pro Glu Lys Gly Cys Gly Leu Ala Pro Pro His
        35                  40                  45              
Tyr Pro Thr Leu Leu Thr Val Pro Ala Ser Val Ser Leu Pro Ser Gly
    50                  55                  60                  
Ile Ser Met Asp Thr Glu Ser Lys Ser Asp Gln Leu Thr Pro His Ser
65                  70                  75                  80  
Gln Ala Ser Val Thr Gln Asn Ile Thr Val Val Pro Val Pro Ser Thr
                85                  90                  95      
Gly Leu Met Thr Ala Ala Leu Gln Val Val Pro Asp Leu Ser Lys Lys
            100                 105                 110         
Val Ala Ser Thr Leu Thr Glu Glu Gly Gly Gly Gly Gly Gly Gly Gly
        115                 120                 125             
Gly Ser Val Ala Pro Lys Pro Pro Arg Gly Arg Lys Lys Lys Arg Met
    130                 135                 140                 
Leu Glu Ser Gly Leu Pro Glu Met Asn Asp Pro Tyr Val Leu Ser Pro
145                 150                 155                 160 
Glu Asp Asp Asp Asp His Gln Lys Asp Gly Lys Thr Tyr Arg Cys Arg
                165                 170                 175     
Met Cys Ser Leu Thr Phe Tyr Ser Lys Ser Glu Met Gln Ile His Ser
            180                 185                 190         
Lys Ser His Thr Glu Thr Lys Pro His Lys Cys Pro His Cys Ser Lys
        195                 200                 205             
Thr Phe Ala Asn Ser Ser Tyr Leu Ala Gln His Ile Arg Ile His Ser
    210                 215                 220                 
Gly Ala Lys Pro Tyr Ser Cys Asn Phe Cys Glu Lys Ser Phe Arg Gln
225                 230                 235                 240 
Leu Ser His Leu Gln Gln His Thr Arg Ile His Thr Gly Asp Arg Pro
                245                 250                 255     
Tyr Lys Cys Ala His Pro Gly Cys Glu Lys Ala Phe Thr Gln Leu Ser
            260                 265                 270         
Asn Leu Gln Ser His Arg Arg Gln His Asn Lys Asp Lys Pro Phe Lys
        275                 280                 285             
Cys His Asn Cys His Arg Ala Tyr Thr Asp Ala Ala Ser Leu Glu Val
    290                 295                 300                 
His Leu Ser Thr His Thr Val Lys His Ala Lys Val Tyr Thr Cys Thr
305                 310                 315                 320 
Ile Cys Ser Arg Ala Tyr Thr Ser Glu Thr Tyr Leu Met Lys His Met
                325                 330                 335     
Arg Lys His Asn Pro Pro Asp Leu Gln Gln Gln Val Gln Ala Ala Ala
            340                 345                 350         
Ala Ala Ala Ala Val Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala
        355                 360                 365             
Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Ser Gln Ala Ser
    370                 375                 380                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro
385                 390                 395                 400 
Pro Pro His Phe Gln Ser Pro Gly Ala Ala Pro Gln Gly Gly Gly Gly
                405                 410                 415     
Gly Asp Ser Asn Pro Asn Pro Pro Pro Gln Cys Ser Phe Asp Leu Thr
            420                 425                 430         
Pro Tyr Lys Thr Ala Glu His His Lys Asp Ile Cys Leu Thr Val Thr
        435                 440                 445             
Thr Ser Thr Ile Gln Val Glu His Leu Ala Ser Ser
    450                 455                 460 


<210> 7999
<211> 233
<212> PRT
<213> Homo sapiens

<400> 7999
Met Gly Glu Pro Gln Gln Val Ser Ala Leu Pro Pro Pro Pro Met Gln
 1               5                  10                  15      
Tyr Ile Lys Glu Tyr Thr Asp Glu Asn Ile Gln Glu Gly Leu Ala Pro
            20                  25                  30          
Lys Pro Pro Pro Pro Ile Lys Asp Ser Tyr Met Met Phe Gly Asn Gln
        35                  40                  45              
Phe Gln Cys Asp Asp Leu Ile Ile Arg Pro Leu Glu Ser Gln Gly Ile
    50                  55                  60                  
Glu Arg Leu His Pro Met Gln Phe Asp His Lys Lys Glu Leu Arg Lys
65                  70                  75                  80  
Leu Asn Met Ser Ile Leu Ile Asn Phe Leu Asp Leu Leu Asp Ile Leu
                85                  90                  95      
Ile Arg Ser Pro Gly Ser Ile Lys Arg Glu Glu Lys Leu Glu Asp Leu
            100                 105                 110         
Lys Leu Leu Phe Val His Val His His Leu Ile Asn Glu Tyr Arg Pro
        115                 120                 125             
His Gln Ala Arg Glu Thr Leu Arg Val Met Met Glu Val Gln Lys Arg
    130                 135                 140                 
Gln Arg Leu Glu Thr Ala Glu Arg Phe Gln Lys His Leu Glu Arg Val
145                 150                 155                 160 
Ile Glu Met Ile Gln Asn Cys Leu Ala Ser Leu Pro Asp Asp Leu Pro
                165                 170                 175     
His Ser Glu Ala Gly Met Arg Val Lys Thr Glu Pro Met Asp Ala Asp
            180                 185                 190         
Asp Ser Asn Asn Cys Thr Gly Gln Asn Glu His Gln Arg Glu Asn Ser
        195                 200                 205             
Gly His Arg Arg Asp Gln Ile Ile Glu Lys Asp Ala Ala Leu Cys Val
    210                 215                 220                 
Leu Ile Asp Glu Met Asn Glu Arg Pro
225                 230             


<210> 8000
<211> 167
<212> PRT
<213> Homo sapiens

<400> 8000
Met Val Ser Asn Phe Phe His Val Ile Gln Val Phe Glu Lys Ser Ala
 1               5                  10                  15      
Thr Leu Ile Ser Lys Thr Glu His Ile Gly Phe Val Ile Tyr Ser Trp
            20                  25                  30          
Arg Lys Ser Thr Thr His Leu Gly Ser Arg Arg Lys Phe Ala Ile Ser
        35                  40                  45              
Ile Tyr Leu Ser Glu Val Ser Leu Gln Lys Tyr Asp Cys Pro Phe Ser
    50                  55                  60                  
Gly Thr Ser Phe Val Val Phe Ser Leu Phe Leu Ile Cys Ala Met Ala
65                  70                  75                  80  
Gly Asp Val Val Tyr Ala Asp Ile Lys Thr Val Arg Thr Ser Pro Leu
                85                  90                  95      
Glu Leu Ala Phe Pro Leu Gln Arg Ser Val Ser Phe Asn Phe Ser Thr
            100                 105                 110         
Val His Lys Ser Cys Pro Ala Lys Asp Trp Lys Val His Lys Gly Lys
        115                 120                 125             
Cys Tyr Trp Ile Ala Glu Thr Lys Lys Ser Trp Asn Lys Ser Gln Asn
    130                 135                 140                 
Asp Cys Ala Ile Asn Asn Ser Tyr Leu Met Val Ile Gln Asp Ile Thr
145                 150                 155                 160 
Ala Met Val Arg Phe Asn Ile
                165         


<210> 8001
<211> 780
<212> PRT
<213> Homo sapiens

<400> 8001
Met Glu Asp Leu Ser Ser Pro Asp Ser Thr Leu Leu Gln Gly Gly His
 1               5                  10                  15      
Asn Leu Leu Ser Ser Ala Ser Phe Gln Glu Ala Val Thr Phe Lys Asp
            20                  25                  30          
Val Ile Val Asp Phe Thr Gln Glu Glu Trp Lys Gln Leu Asp Pro Gly
        35                  40                  45              
Gln Arg Asp Leu Phe Arg Asp Val Thr Leu Glu Asn Tyr Thr His Leu
    50                  55                  60                  
Val Ser Ile Gly Leu Gln Val Ser Lys Pro Asp Val Ile Ser Gln Leu
65                  70                  75                  80  
Glu Gln Gly Thr Glu Pro Trp Ile Met Glu Pro Ser Ile Pro Val Gly
                85                  90                  95      
Thr Cys Ala Asp Trp Glu Thr Arg Leu Glu Asn Ser Val Ser Ala Pro
            100                 105                 110         
Glu Pro Asp Ile Ser Glu Glu Glu Leu Ser Pro Glu Val Ile Val Glu
        115                 120                 125             
Lys His Lys Arg Asp Asp Ser Trp Ser Ser Asn Leu Leu Glu Ser Trp
    130                 135                 140                 
Glu Tyr Glu Gly Ser Leu Glu Arg Gln Gln Ala Asn Gln Gln Thr Leu
145                 150                 155                 160 
Pro Lys Glu Ile Lys Val Thr Glu Lys Thr Ile Pro Ser Trp Glu Lys
                165                 170                 175     
Gly Pro Val Asn Asn Glu Phe Gly Lys Ser Val Asn Val Ser Ser Asn
            180                 185                 190         
Leu Val Thr Gln Glu Pro Ser Pro Glu Glu Thr Ser Thr Lys Arg Ser
        195                 200                 205             
Ile Lys Gln Asn Ser Asn Pro Val Lys Lys Glu Lys Ser Cys Lys Cys
    210                 215                 220                 
Asn Glu Cys Gly Lys Ala Phe Ser Tyr Cys Ser Ala Leu Ile Arg His
225                 230                 235                 240 
Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Glu
                245                 250                 255     
Lys Ala Phe Ser Arg Ser Glu Asn Leu Ile Asn His Gln Arg Ile His
            260                 265                 270         
Thr Gly Asp Lys Pro Tyr Lys Cys Asp Gln Cys Gly Lys Gly Phe Ile
        275                 280                 285             
Glu Gly Pro Ser Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys
    290                 295                 300                 
Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Phe Ser Gln Arg Thr His
305                 310                 315                 320 
Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys
                325                 330                 335     
Asn Glu Cys Gly Lys Ala Phe Ser Gln Arg Gly His Phe Met Glu His
            340                 345                 350         
Gln Lys Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Asp
        355                 360                 365             
Lys Thr Phe Thr Arg Ser Thr His Leu Thr Gln His Gln Lys Ile His
    370                 375                 380                 
Thr Gly Glu Lys Thr Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Asn
385                 390                 395                 400 
Gly Pro Ser Thr Phe Ile Arg His His Met Ile His Thr Gly Glu Lys
                405                 410                 415     
Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln His Ser Asn
            420                 425                 430         
Leu Thr Gln His Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Asp Cys
        435                 440                 445             
Ala Glu Cys Gly Lys Ser Phe Ser Tyr Trp Ser Ser Leu Ala Gln His
    450                 455                 460                 
Leu Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly
465                 470                 475                 480 
Lys Ala Phe Ser Tyr Cys Ser Ser Leu Thr Gln His Arg Arg Ile His
                485                 490                 495     
Thr Arg Glu Lys Pro Phe Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser
            500                 505                 510         
Tyr Leu Ser Asn Leu Asn Gln His Gln Lys Thr His Thr Gln Glu Lys
        515                 520                 525             
Ala Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile Arg Ser Ser Ser
    530                 535                 540                 
Leu Ala Lys His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys
545                 550                 555                 560 
His Glu Cys Gly Lys Thr Phe Ser Tyr Gly Ser Ser Leu Ile Gln His
                565                 570                 575     
Arg Lys Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Asn Glu Cys Gly
            580                 585                 590         
Arg Ala Phe Asn Gln Asn Ile His Leu Thr Gln His Lys Arg Ile His
        595                 600                 605             
Thr Gly Ala Lys Pro Tyr Glu Cys Ala Glu Cys Gly Lys Ala Phe Arg
    610                 615                 620                 
His Cys Ser Ser Leu Ala Gln His Gln Lys Thr His Thr Glu Glu Lys
625                 630                 635                 640 
Pro Tyr Gln Cys Asn Lys Cys Glu Lys Thr Phe Ser Gln Ser Ser His
                645                 650                 655     
Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
            660                 665                 670         
Asn Glu Cys Asp Lys Ala Phe Ser Arg Ser Thr His Leu Thr Glu His
        675                 680                 685             
Gln Asn Thr His Thr Gly Glu Lys Pro Tyr Asn Cys Asn Glu Cys Arg
    690                 695                 700                 
Lys Thr Phe Ser Gln Ser Thr Tyr Leu Ile Gln His Gln Arg Met His
705                 710                 715                 720 
Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Asn Ala Phe Ser
                725                 730                 735     
Asp Cys Ser Ser Leu Ile Gln His Gln Arg Thr His Thr Gly Glu Glu
            740                 745                 750         
Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Arg Ser Thr Tyr
        755                 760                 765             
Leu Thr Gln His Gln Arg Ser His Ala Gly Glu Lys
    770                 775                 780 


<210> 8002
<211> 892
<212> PRT
<213> Homo sapiens

<400> 8002
Met Glu Asp Leu Ser Ser Pro Asp Ser Thr Leu Leu Gln Gly Gly His
 1               5                  10                  15      
Asn Leu Leu Ser Ser Ala Ser Phe Gln Glu Ala Val Thr Phe Lys Asp
            20                  25                  30          
Val Ile Val Asp Phe Thr Gln Glu Glu Trp Lys Gln Leu Asp Pro Gly
        35                  40                  45              
Gln Arg Asp Leu Phe Arg Asp Val Thr Leu Glu Asn Tyr Thr His Leu
    50                  55                  60                  
Val Ser Ile Gly Leu Gln Val Ser Lys Pro Asp Val Ile Ser Gln Leu
65                  70                  75                  80  
Glu Gln Gly Thr Glu Pro Trp Ile Met Glu Pro Ser Ile Pro Val Gly
                85                  90                  95      
Thr Cys Ala Asp Trp Glu Thr Arg Leu Glu Asn Ser Val Ser Ala Pro
            100                 105                 110         
Glu Pro Asp Ile Ser Glu Glu Glu Leu Ser Pro Glu Val Ile Val Glu
        115                 120                 125             
Lys His Lys Arg Asp Asp Ser Trp Ser Ser Asn Leu Leu Glu Ser Trp
    130                 135                 140                 
Glu Tyr Glu Gly Ser Leu Glu Arg Gln Gln Ala Asn Gln Gln Thr Leu
145                 150                 155                 160 
Pro Lys Glu Ile Lys Val Thr Glu Lys Thr Ile Pro Ser Trp Glu Lys
                165                 170                 175     
Gly Pro Val Asn Asn Glu Phe Gly Lys Ser Val Asn Val Ser Ser Asn
            180                 185                 190         
Leu Val Thr Gln Glu Pro Ser Pro Glu Glu Thr Ser Thr Lys Arg Ser
        195                 200                 205             
Ile Lys Gln Asn Ser Asn Pro Val Lys Lys Glu Lys Ser Cys Lys Cys
    210                 215                 220                 
Asn Glu Cys Gly Lys Ala Phe Ser Tyr Cys Ser Ala Leu Ile Arg His
225                 230                 235                 240 
Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Glu
                245                 250                 255     
Lys Ala Phe Ser Arg Ser Glu Asn Leu Ile Asn His Gln Arg Ile His
            260                 265                 270         
Thr Gly Asp Lys Pro Tyr Lys Cys Asp Gln Cys Gly Lys Gly Phe Ile
        275                 280                 285             
Glu Gly Pro Ser Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys
    290                 295                 300                 
Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Phe Ser Gln Arg Thr His
305                 310                 315                 320 
Leu Val Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys
                325                 330                 335     
Asn Glu Cys Gly Lys Ala Phe Ser Gln Arg Gly His Phe Met Glu His
            340                 345                 350         
Gln Lys Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Asp
        355                 360                 365             
Lys Thr Phe Thr Arg Ser Thr His Leu Thr Gln His Gln Lys Ile His
    370                 375                 380                 
Thr Gly Glu Lys Thr Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Asn
385                 390                 395                 400 
Gly Pro Ser Thr Phe Ile Arg His His Met Ile His Thr Gly Glu Lys
                405                 410                 415     
Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln His Ser Asn
            420                 425                 430         
Leu Thr Gln His Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Asp Cys
        435                 440                 445             
Ala Glu Cys Gly Lys Ser Phe Ser Tyr Trp Ser Ser Leu Ala Gln His
    450                 455                 460                 
Leu Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly
465                 470                 475                 480 
Lys Ala Phe Ser Tyr Cys Ser Ser Leu Thr Gln His Arg Arg Ile His
                485                 490                 495     
Thr Arg Glu Lys Pro Phe Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser
            500                 505                 510         
Tyr Leu Ser Asn Leu Asn Gln His Gln Lys Thr His Thr Gln Glu Lys
        515                 520                 525             
Ala Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile Arg Ser Ser Ser
    530                 535                 540                 
Leu Ala Lys His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys
545                 550                 555                 560 
His Glu Cys Gly Lys Thr Phe Ser Tyr Gly Ser Ser Leu Ile Gln His
                565                 570                 575     
Arg Lys Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Asn Glu Cys Gly
            580                 585                 590         
Arg Ala Phe Asn Gln Asn Ile His Leu Thr Gln His Lys Arg Ile His
        595                 600                 605             
Thr Gly Ala Lys Pro Tyr Glu Cys Ala Glu Cys Gly Lys Ala Phe Arg
    610                 615                 620                 
His Cys Ser Ser Leu Ala Gln His Gln Lys Thr His Thr Glu Glu Lys
625                 630                 635                 640 
Pro Tyr Gln Cys Asn Lys Cys Glu Lys Thr Phe Ser Gln Ser Ser His
                645                 650                 655     
Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
            660                 665                 670         
Asn Glu Cys Asp Lys Ala Phe Ser Arg Ser Thr His Leu Thr Glu His
        675                 680                 685             
Gln Asn Thr His Thr Gly Glu Lys Pro Tyr Asn Cys Asn Glu Cys Arg
    690                 695                 700                 
Lys Thr Phe Ser Gln Ser Thr Tyr Leu Ile Gln His Gln Arg Ile His
705                 710                 715                 720 
Ser Gly Glu Lys Pro Phe Gly Cys Asn Asp Cys Gly Lys Ser Phe Arg
                725                 730                 735     
Tyr Arg Ser Ala Leu Asn Lys His Gln Arg Leu His Pro Gly Arg Glu
            740                 745                 750         
Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser Tyr Cys Leu
        755                 760                 765             
Val Leu Asn Gln His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Glu
    770                 775                 780                 
Gly Thr Glu Cys Gly Lys Thr Phe Ser Arg Ser Thr Tyr Leu Thr Gln
785                 790                 795                 800 
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Leu Glu Cys
                805                 810                 815     
Gly Lys Ala Phe Ser Gln Asn Thr His Leu Thr Leu His Gln Arg Ile
            820                 825                 830         
His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Arg Ser Phe
        835                 840                 845             
Ser Gln Ser Ala His Leu Thr Gln His Gln Arg Met Tyr Thr Gly Glu
    850                 855                 860                 
Lys Leu Tyr Glu Cys Asn Glu Cys Glu Lys Ala Phe His Asp His Ser
865                 870                 875                 880 
Ala Leu Ile Gln His His Ile Val His Thr Ala Glu
                885                 890         


<210> 8003
<211> 268
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 231
<223> Xaa = Any Amino Acid

<400> 8003
Met Val Arg Gln Thr Asn Asn Val Gln Ile Cys Ala Thr Val Arg Gly
 1               5                  10                  15      
Leu Leu Pro Ile Leu Asp Ser Ser Gly Pro Cys Cys Thr Leu Lys Glu
            20                  25                  30          
Phe Leu Asn Val Gln Glu Asn Ser Gly His Pro Leu Asp Thr Pro Phe
        35                  40                  45              
Ser Trp Trp Asp Leu Pro Gln Gln Ala His Gln Arg Gly Gly Leu His
    50                  55                  60                  
His Pro Asp Ile Ala Gln Ala Ala Gly Thr Val Lys Ile Trp Thr Ser
65                  70                  75                  80  
Glu His Val Phe Asp His Ser Trp Glu Thr Val Thr Thr Ala Ala Met
                85                  90                  95      
Gln Lys Tyr Pro Asn Pro Tyr Glu Pro Thr Val Val Gly Val Asp Val
            100                 105                 110         
Leu Asp Arg His Val Asp Pro Ser Gly Lys Leu His Ser His Arg Leu
        115                 120                 125             
Leu Ser Thr Glu Trp Gly Leu Pro Ser Ile Val Lys Ser Leu Ile Gly
    130                 135                 140                 
Ala Ala Arg Met Lys Thr Tyr Val Gln Glu His Ser Val Val Asp Pro
145                 150                 155                 160 
Val Glu Lys Thr Met Lys Leu Lys Ser Thr Asn Ile Ser Phe Thr Asp
                165                 170                 175     
Met Val Ser Ala Asp Glu Arg Leu Ile Tyr Lys Pro Arg Pro Arg Asp
            180                 185                 190         
Pro Glu Lys Thr Ile Leu Thr Gln Glu Ala Ile Ile Thr Met Lys Gly
        195                 200                 205             
Val Ser Leu Ser Ser Tyr Phe Glu Glu Leu Met Ala Ser Met Ile Ser
    210                 215                 220                 
Ser Asn Thr Ser Lys Gly Xaa Glu Ala Ile Glu Trp Val Ile His Lys
225                 230                 235                 240 
Leu Asn Ala Glu Ile Glu Glu Leu Thr Ala Ser Ala Arg Gly Ser Ile
                245                 250                 255     
Arg Thr Pro Met Ala Ala Ala Ala Phe Ala Asp Lys
            260                 265             


<210> 8004
<211> 763
<212> PRT
<213> Homo sapiens

<400> 8004
Met Val Ala Cys Arg Ala Ile Gly Ile Leu Ser Arg Phe Ser Ala Phe
 1               5                  10                  15      
Arg Ile Leu Arg Ser Arg Gly Tyr Ile Cys Arg Asn Phe Thr Gly Ser
            20                  25                  30          
Ser Ala Leu Leu Thr Arg Thr His Ile Asn Tyr Gly Val Lys Gly Asp
        35                  40                  45              
Val Ala Val Val Arg Ile Asn Ser Pro Asn Ser Lys Val Asn Thr Leu
    50                  55                  60                  
Ser Lys Glu Leu His Ser Glu Phe Ser Glu Val Met Asn Glu Ile Trp
65                  70                  75                  80  
Ala Ser Asp Gln Ile Arg Ser Ala Val Leu Ile Ser Ser Lys Pro Gly
                85                  90                  95      
Cys Phe Ile Ala Gly Ala Asp Ile Asn Met Leu Ala Ala Cys Lys Thr
            100                 105                 110         
Leu Gln Glu Val Thr Gln Leu Ser Gln Glu Ala Gln Arg Ile Val Glu
        115                 120                 125             
Lys Leu Glu Lys Ser Thr Lys Pro Ile Val Ala Ala Ile Asn Gly Ser
    130                 135                 140                 
Cys Leu Gly Gly Gly Leu Glu Val Ala Ile Ser Cys Gln Tyr Arg Ile
145                 150                 155                 160 
Ala Thr Lys Asp Arg Lys Thr Val Leu Gly Thr Pro Glu Val Leu Leu
                165                 170                 175     
Gly Ala Leu Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Lys Met Val
            180                 185                 190         
Gly Val Pro Ala Ala Leu Asp Met Met Leu Thr Gly Arg Ser Ile Arg
        195                 200                 205             
Ala Asp Arg Ala Lys Lys Met Gly Leu Val Asp Gln Leu Val Glu Pro
    210                 215                 220                 
Leu Gly Pro Gly Leu Lys Pro Pro Glu Glu Arg Thr Ile Glu Tyr Leu
225                 230                 235                 240 
Glu Glu Val Ala Ile Thr Phe Ala Lys Gly Leu Ala Asp Lys Lys Ile
                245                 250                 255     
Ser Pro Lys Arg Asp Lys Gly Leu Val Glu Lys Leu Thr Ala Tyr Ala
            260                 265                 270         
Met Thr Ile Pro Phe Val Arg Gln Gln Val Tyr Lys Lys Val Glu Glu
        275                 280                 285             
Lys Val Arg Lys Gln Thr Lys Gly Leu Tyr Pro Ala Pro Leu Lys Ile
    290                 295                 300                 
Ile Asp Val Val Lys Thr Gly Ile Glu Gln Gly Ser Asp Ala Gly Tyr
305                 310                 315                 320 
Leu Cys Glu Ser Gln Lys Phe Gly Glu Leu Val Met Thr Lys Glu Ser
                325                 330                 335     
Lys Ala Leu Met Gly Leu Tyr His Gly Gln Val Leu Cys Lys Lys Asn
            340                 345                 350         
Lys Phe Gly Ala Pro Gln Lys Asp Val Lys His Leu Ala Ile Leu Gly
        355                 360                 365             
Ala Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ser Val Asp Lys Gly
    370                 375                 380                 
Leu Lys Thr Ile Leu Lys Asp Ala Thr Leu Thr Ala Leu Asp Arg Gly
385                 390                 395                 400 
Gln Gln Gln Val Phe Lys Gly Leu Asn Asp Lys Val Lys Lys Lys Ala
                405                 410                 415     
Leu Thr Ser Phe Glu Arg Asp Ser Ile Phe Ser Asn Leu Thr Gly Gln
            420                 425                 430         
Leu Asp Tyr Gln Gly Phe Glu Lys Ala Asp Met Val Ile Glu Ala Val
        435                 440                 445             
Phe Glu Asp Leu Ser Leu Lys His Arg Val Leu Lys Glu Val Glu Ala
    450                 455                 460                 
Val Ile Pro Asp His Cys Ile Phe Ala Ser Asn Thr Ser Ala Leu Pro
465                 470                 475                 480 
Ile Ser Glu Ile Ala Ala Val Ser Lys Arg Pro Glu Lys Val Ile Gly
                485                 490                 495     
Met His Tyr Phe Ser Pro Val Asp Lys Met Gln Leu Leu Glu Ile Ile
            500                 505                 510         
Thr Thr Glu Lys Thr Ser Lys Asp Thr Ser Ala Ser Ala Val Ala Val
        515                 520                 525             
Gly Leu Lys Gln Gly Lys Val Ile Ile Val Val Lys Asp Gly Pro Gly
    530                 535                 540                 
Phe Tyr Thr Thr Arg Cys Leu Ala Pro Met Met Ser Glu Val Ile Arg
545                 550                 555                 560 
Ile Leu Gln Glu Gly Val Asp Pro Lys Lys Leu Asp Ser Leu Thr Thr
                565                 570                 575     
Ser Phe Gly Phe Pro Val Gly Ala Ala Thr Leu Val Asp Glu Val Gly
            580                 585                 590         
Val Asp Val Ala Lys His Val Ala Glu Asp Leu Gly Lys Val Phe Gly
        595                 600                 605             
Glu Arg Phe Gly Gly Gly Asn Pro Glu Leu Leu Thr Gln Met Val Ser
    610                 615                 620                 
Lys Gly Phe Leu Gly Arg Lys Ser Gly Lys Gly Phe Tyr Ile Tyr Gln
625                 630                 635                 640 
Glu Gly Val Lys Arg Lys Asp Leu Asn Ser Asp Met Asp Ser Ile Leu
                645                 650                 655     
Ala Ser Leu Lys Leu Pro Pro Lys Ser Glu Val Ser Ser Asp Glu Asp
            660                 665                 670         
Ile Gln Phe Arg Leu Val Thr Arg Phe Val Asn Glu Ala Val Met Cys
        675                 680                 685             
Leu Gln Glu Gly Ile Leu Ala Thr Pro Ala Glu Gly Asp Ile Gly Ala
    690                 695                 700                 
Val Phe Gly Leu Gly Phe Pro Pro Cys Leu Gly Gly Pro Phe Arg Phe
705                 710                 715                 720 
Val Asp Leu Tyr Gly Ala Gln Lys Ile Val Asp Arg Leu Lys Lys Tyr
                725                 730                 735     
Glu Ala Ala Tyr Gly Lys Gln Phe Thr Pro Cys Gln Leu Leu Ala Asp
            740                 745                 750         
His Ala Asn Ser Pro Asn Lys Lys Phe Tyr Gln
        755                 760             


<210> 8005
<211> 445
<212> PRT
<213> Homo sapiens

<400> 8005
Met Glu Thr Arg Thr Glu Asp Gly Gly Leu Thr Arg Arg Pro Thr Leu
 1               5                  10                  15      
Ala Ser Ser Trp Asp Val Ala Gly Gly Ala Leu Thr His Ser Leu Leu
            20                  25                  30          
Leu Thr Arg Ala Gly Leu Gly Pro Gly Asp Phe Asp Trp Glu Glu Leu
        35                  40                  45              
Leu Ala Pro Pro Ala Pro Gly Gln Asp Leu Val Ile Leu Lys Arg Asn
    50                  55                  60                  
His Asn Asn Lys Asp Glu Asn Pro Cys Phe Leu Tyr Leu Arg Cys Gly
65                  70                  75                  80  
Pro Asp Gly Gly Glu Glu Ile Ala Ser Ile Gly Ile Leu Ser Ser Ala
                85                  90                  95      
Arg Asn Met Glu Val Tyr Leu Gly Glu Glu Tyr Cys Gly Thr Ser Arg
            100                 105                 110         
Gly Lys Asn Val Cys Thr Val Leu Asp Asp Ser Glu His Glu Lys Ile
        115                 120                 125             
Ile Leu Tyr Lys Lys Asn Leu Lys Leu Glu Ser Ser Thr His Ala Cys
    130                 135                 140                 
Lys Ile Lys Leu Leu Ser Phe Gly Glu Arg Gln Cys Val Phe Ile Ser
145                 150                 155                 160 
Lys Val Val Val His Met Arg Ser Val Phe Ala Asn Ser Ser Thr Ser
                165                 170                 175     
Ser Pro Ala Leu Gly Ser Arg Ile Asp Leu Asp Lys Val Gln Thr Ile
            180                 185                 190         
Met Glu Ser Met Gly Ser Lys Leu Ser Pro Gly Ala Gln Gln Leu Met
        195                 200                 205             
Asp Met Val Arg Cys Gln Gln Arg Asn Cys Ile Pro Ile Gly Glu Gln
    210                 215                 220                 
Leu Gln Ser Val Leu Gly Asn Ser Gly Tyr Lys His Met Ile Gly Leu
225                 230                 235                 240 
Gln Ser Ser Ser Thr Leu Gly Thr Leu Asn Lys Ser Ser Ser Thr Pro
                245                 250                 255     
Phe Pro Phe Arg Thr Gly Leu Thr Ser Gly Asn Val Thr Glu Asn Leu
            260                 265                 270         
Gln Thr Tyr Ile Asp Lys Ser Thr Gln Leu Pro Gly Gly Glu Asn Ser
        275                 280                 285             
Thr Lys Leu Asp Glu Cys Lys Val Met Pro Gln Asn His Ser Phe Leu
    290                 295                 300                 
Glu Asn Asp Leu Lys Asn Ala Met Ala Ser Phe Leu Pro Lys Lys Val
305                 310                 315                 320 
Ser Asp Asn Ser Asn Ile Pro Asn Ser Glu Leu Leu Pro Phe Leu Gln
                325                 330                 335     
Asn Leu Cys Ser Gln Val Asn His Leu His Val Gly Asn Lys Thr Glu
            340                 345                 350         
Cys Gln Glu Asn Ile Thr Lys His Gly Glu Arg Ile Leu Gly Val Gly
        355                 360                 365             
Met Glu Glu Gln Ser Ile Cys Ser Tyr Leu Glu Lys Ile Leu Ser Lys
    370                 375                 380                 
Asn Met Glu Leu Met Glu Lys Lys Leu Met Asp Tyr Ile Asp Gln Arg
385                 390                 395                 400 
Ile His Glu Leu Gln Glu His Ile Asp Asp Lys Ile Ala Leu Leu Leu
                405                 410                 415     
Asp Leu Leu Gln Asn Pro Asn Ser Pro Pro Thr Gly Ile Pro Leu Arg
            420                 425                 430         
His Tyr Asp Ser Gly Glu Arg Leu Ser Asn Gly Glu Arg
        435                 440                 445 


<210> 8006
<211> 1047
<212> PRT
<213> Homo sapiens

<400> 8006
Met Asp Ala Asn Ser Lys Asp Lys Pro Pro Glu Thr Lys Glu Ser Ala
 1               5                  10                  15      
Met Asn Asn Ala Gly Asn Ala Ser Phe Ile Leu Gly Thr Gly Lys Ile
            20                  25                  30          
Val Thr Pro Gln Lys His Ala Glu Leu Pro Pro Asn Pro Cys Thr Pro
        35                  40                  45              
Asp Thr Phe Lys Ser Pro Leu Asn Phe Ser Thr Val Thr Val Glu Gln
    50                  55                  60                  
Leu Gly Ile Thr Pro Glu Ser Phe Val Arg Asn Ser Ala Gly Lys Ser
65                  70                  75                  80  
Ser Ser Tyr Leu Lys Lys Cys Arg Arg Arg Ser Ala Val Gly Ala Arg
                85                  90                  95      
Gly Ser Pro Glu Thr Asn His Leu Ile Arg Phe Ile Ala Arg Gln Gln
            100                 105                 110         
Asn Ile Lys Asn Ala Arg Lys Ser Pro Leu Ala Gln Asp Ser Pro Ser
        115                 120                 125             
Gln Gly Ser Pro Ala Leu Tyr Arg Asn Val Asn Thr Leu Arg Glu Arg
    130                 135                 140                 
Ile Ser Ala Phe Gln Ser Ala Phe His Ser Ile Lys Glu Asn Glu Lys
145                 150                 155                 160 
Met Thr Gly Cys Leu Glu Phe Ser Glu Ala Gly Lys Glu Ser Glu Met
                165                 170                 175     
Thr Asp Leu Thr Arg Lys Glu Gly Leu Ser Ala Cys Gln Gln Ser Gly
            180                 185                 190         
Phe Pro Ala Val Leu Ser Ser Lys Arg Arg Arg Ile Ser Tyr Gln Arg
        195                 200                 205             
Asp Ser Asp Glu Asn Leu Thr Asp Ala Glu Gly Lys Val Ile Gly Leu
    210                 215                 220                 
Gln Ile Phe Asn Ile Asp Thr Asp Arg Ala Cys Ala Val Glu Thr Ser
225                 230                 235                 240 
Val Asp Leu Ser Glu Ile Ser Ser Lys Leu Gly Ser Thr Gln Ser Gly
                245                 250                 255     
Phe Leu Val Glu Glu Ser Leu Pro Leu Ser Glu Leu Thr Glu Thr Ser
            260                 265                 270         
Asn Ala Gly Asn Pro Thr Ser Asn Ser Ala Asn Leu Pro Ala Phe Ser
        275                 280                 285             
Ala Pro Ala Pro Glu Leu Leu Ile Phe Ala Leu Lys Val Ala Asp Cys
    290                 295                 300                 
Val Val Gly Lys Gly Ser Ser Asp Ala Val Ser Pro Asp Thr Phe Thr
305                 310                 315                 320 
Ala Glu Val Ser Ser Asp Ala Val Pro Asp Val Arg Ser Pro Ala Thr
                325                 330                 335     
Pro Ala Cys Arg Arg Asp Leu Pro Thr Pro Lys Thr Phe Val Leu Arg
            340                 345                 350         
Ser Val Leu Lys Lys Pro Ser Val Lys Met Cys Leu Glu Ser Leu Gln
        355                 360                 365             
Glu His Cys Asn Asn Leu Tyr Asp Asp Asp Gly Thr His Pro Ser Leu
    370                 375                 380                 
Ile Ser Asn Leu Pro Asn Cys Cys Lys Glu Lys Glu Ala Glu Asp Glu
385                 390                 395                 400 
Glu Asn Phe Glu Ala Pro Ala Phe Leu Asn Met Arg Lys Arg Lys Arg
                405                 410                 415     
Val Thr Phe Gly Glu Asp Leu Ser Pro Glu Val Phe Asp Glu Ser Leu
            420                 425                 430         
Pro Ala Asn Thr Pro Leu Arg Lys Gly Gly Thr Pro Val Cys Lys Lys
        435                 440                 445             
Asp Phe Ser Gly Leu Ser Ser Leu Leu Leu Glu Gln Ser Pro Val Pro
    450                 455                 460                 
Glu Pro Leu Pro Gln Pro Asp Phe Asp Asp Lys Gly Glu Asn Leu Glu
465                 470                 475                 480 
Asn Ile Glu Pro Leu Gln Val Ser Phe Ala Val Leu Ser Ser Pro Asn
                485                 490                 495     
Lys Ser Ser Ile Ser Glu Thr Leu Ser Gly Thr Asp Thr Phe Ser Ser
            500                 505                 510         
Ser Asn Asn His Glu Lys Ile Ser Ser Pro Lys Val Gly Arg Ile Thr
        515                 520                 525             
Arg Thr Ser Asn Arg Arg Asn Gln Leu Val Ser Val Val Glu Glu Ser
    530                 535                 540                 
Val Cys Asn Leu Leu Asn Thr Glu Val Gln Pro Cys Lys Glu Lys Lys
545                 550                 555                 560 
Ile Asn Arg Arg Lys Ser Gln Glu Thr Lys Cys Thr Lys Arg Ala Leu
                565                 570                 575     
Pro Lys Lys Ser Gln Val Leu Lys Ser Cys Arg Lys Lys Lys Gly Lys
            580                 585                 590         
Gly Lys Lys Ser Val Gln Lys Ser Leu Tyr Gly Glu Arg Asp Ile Ala
        595                 600                 605             
Ser Lys Lys Pro Leu Leu Ser Pro Ile Pro Glu Leu Pro Glu Val Pro
    610                 615                 620                 
Glu Met Thr Pro Ser Ile Pro Ser Ile Arg Arg Leu Gly Ser Gly Tyr
625                 630                 635                 640 
Phe Ser Ser Asn Gly Lys Leu Glu Glu Val Lys Thr Pro Lys Asn Pro
                645                 650                 655     
Val Lys Arg Lys Asp Leu Leu Arg His Asp Pro Asp Leu His Met His
            660                 665                 670         
Gln Gly Tyr Asp Lys Tyr Asp Val Ser Glu Phe Cys Ser Tyr Ile Lys
        675                 680                 685             
Ser Ser Ser Ser Leu Gly Asn Ala Thr Ser Asp Glu Asp Pro Asn Thr
    690                 695                 700                 
Asn Ile Met Asn Ile Asn Glu Asn Lys Asn Ile Pro Lys Ala Lys Asn
705                 710                 715                 720 
Lys Ser Glu Ser Glu Asn Glu Pro Lys Ala Gly Thr Asp Ser Pro Val
                725                 730                 735     
Ser Cys Ala Ser Val Thr Glu Glu Arg Val Ala Ser Asp Ser Pro Lys
            740                 745                 750         
Pro Ala Leu Thr Leu Gln Gln Gly Gln Glu Phe Ser Ala Gly Gly Gln
        755                 760                 765             
Asn Ala Glu Asn Leu Cys Gln Phe Phe Lys Ile Ser Pro Asp Leu Asn
    770                 775                 780                 
Ile Lys Cys Glu Arg Lys Asp Asp Phe Leu Gly Ala Ala Glu Gly Lys
785                 790                 795                 800 
Leu Gln Cys Asn Arg Leu Met Pro Asn Ser Gln Lys Asp Cys His Cys
                805                 810                 815     
Leu Gly Asp Val Leu Ile Glu Asn Thr Lys Glu Ser Lys Ser Gln Ser
            820                 825                 830         
Glu Asp Leu Gly Arg Lys Pro Met Glu Ser Ser Ser Val Val Ser Cys
        835                 840                 845             
Arg Asp Arg Lys Asp Arg Arg Arg Ser Met Cys Tyr Ser Asp Gly Arg
    850                 855                 860                 
Ser Leu His Leu Glu Lys Asn Gly Asn His Thr Pro Ser Ser Ser Val
865                 870                 875                 880 
Gly Ser Ser Val Glu Ile Ser Leu Glu Asn Ser Glu Leu Phe Lys Asp
                885                 890                 895     
Leu Ser Asp Ala Ile Glu Gln Thr Phe Gln Arg Arg Asn Ser Glu Thr
            900                 905                 910         
Lys Val Arg Arg Ser Thr Arg Leu Gln Lys Asp Leu Glu Asn Glu Gly
        915                 920                 925             
Leu Val Trp Ile Ser Leu Pro Leu Pro Ser Thr Ser Gln Lys Ala Lys
    930                 935                 940                 
Arg Arg Thr Ile Cys Thr Phe Asp Ser Ser Gly Phe Glu Ser Met Ser
945                 950                 955                 960 
Pro Ile Lys Glu Thr Val Ser Ser Arg Gln Lys Pro Gln Met Ala Pro
                965                 970                 975     
Pro Val Ser Asp Pro Glu Asn Ser Gln Gly Pro Ala Ala Gly Ser Ser
            980                 985                 990         
Asp Glu Pro Gly Lys Arg Arg Lys Ser Phe Cys Ile Ser Thr Leu Ala
        995                 1000                1005            
Asn Thr Lys Ala Thr Ser Gln Phe Lys Gly Tyr Arg Arg Arg Ser Ser
    1010                1015                1020                
Leu Asn Gly Lys Gly Glu Ser Ser Leu Thr Ala Leu Glu Arg Ile Glu
1025                1030                1035                1040
His Asn Gly Glu Arg Lys Gln
                1045        


<210> 8007
<211> 568
<212> PRT
<213> Homo sapiens

<400> 8007
Met Ala Gln Val Asp Ser Gln Asp Arg Trp Gly Glu Ala Ser Pro Leu
 1               5                  10                  15      
Ser Ser Leu Thr Glu Glu Ala His Asp Thr Gln Met Leu Ser Met Asn
            20                  25                  30          
Leu Glu Ser Asp Asp Glu Asp Gly Gly Glu Ala Glu Lys Glu Gly Thr
        35                  40                  45              
Ala Asp Pro Val Ala Cys Pro Arg Gly Ser Ser Pro Val Thr His Glu
    50                  55                  60                  
Asn Pro Asp Leu Pro Trp Pro His Pro Leu Gly Lys Glu Glu Glu Lys
65                  70                  75                  80  
Phe Ser Asp Ser Ser Ser Ala Gly Gly Met Gly Gln Lys Pro Val Glu
                85                  90                  95      
Met Ser Gly Lys Ala Ser Trp Ser Arg Asp Val Thr Lys Ile Asn Glu
            100                 105                 110         
Thr Gln Gly Ser Pro Gly Ala Ser Arg Ala Leu Gly Ser Leu Pro Ser
        115                 120                 125             
Gly Leu Ala His Lys Leu Leu Gly Gln Met Gln Pro Leu Gly Asp Arg
    130                 135                 140                 
Leu Pro Ala Gly Asp Asp Gly Tyr Ser Gly Ala Asn Gln Asp Ala Val
145                 150                 155                 160 
Leu Asp Val Pro Pro Ser Phe Pro Ser Asn Gly Lys Tyr Leu Cys Ala
                165                 170                 175     
His Lys Ser Val Asp Thr Ser Ala Gly Asn Ser Ser Leu Leu Cys Phe
            180                 185                 190         
Pro Arg Pro Gly Ser Asn Trp Asp Leu Pro Thr Gln Glu Thr His Thr
        195                 200                 205             
Pro Ala Gln Ala Ser Ala Thr Pro Ala Ser Leu Ala Ala Ala Val Leu
    210                 215                 220                 
Ala Lys Ala Arg Asn Ser Arg Lys Val Gln Asn Gln Ala Gly Arg Arg
225                 230                 235                 240 
Glu Gly Gly Glu Ala Glu Ala Arg Pro Tyr Arg Cys Leu Arg Gly Gly
                245                 250                 255     
Arg Ala Phe Gln Lys Pro Ser Lys Pro Leu Ser Pro Ala Glu Thr Arg
            260                 265                 270         
Gly Gly Ala Ala Lys Arg Tyr Ala Cys Glu Leu Cys Gly Lys Ala Tyr
        275                 280                 285             
Ser His Arg Gly Thr Leu Gln Gln His Arg Arg Leu His Thr Gly Glu
    290                 295                 300                 
Arg Pro Tyr Gln Cys Ser Phe Cys Asp Lys Ala Tyr Thr Trp Ser Ser
305                 310                 315                 320 
Asp His Arg Lys His Ile Arg Thr His Thr Gly Glu Lys Pro Tyr Pro
                325                 330                 335     
Cys Pro Asp Cys Gly Lys Ala Phe Val Arg Ser Ser Asp Leu Arg Lys
            340                 345                 350         
His Gln Arg Asn Met His Ser Asn Asn Lys Pro Phe Pro Cys Ser Glu
        355                 360                 365             
Cys Gly Leu Thr Phe Asn Lys Pro Leu Ser Leu Leu Arg His Gln Arg
    370                 375                 380                 
Thr His Leu Gly Ala Lys Pro Phe Arg Cys Pro Ala Cys Asp Arg Glu
385                 390                 395                 400 
Phe Ala Val Ala Ser Arg Met Val Glu His Gln Arg Val His Ser Gly
                405                 410                 415     
Glu Arg Pro Phe Pro Cys Pro Thr Cys Gly Lys Cys Phe Thr Lys Ser
            420                 425                 430         
Ser Asn Leu Ser Glu His Gln Thr Leu His Thr Gly Gln Arg Pro Phe
        435                 440                 445             
Lys Cys Ala Asp Cys Gly Val Ala Phe Ala Gln Pro Ser Arg Leu Val
    450                 455                 460                 
Arg His Gln Arg Ile His Thr Gly Glu Arg Pro Phe Pro Cys Thr Gln
465                 470                 475                 480 
Cys Gly Gln Ala Phe Ala Arg Ser Ser Thr Leu Lys Arg His Gln Gln
                485                 490                 495     
Ile His Ser Gly Glu Lys Gly Phe Leu Cys Ala Glu Cys Gly Arg Ala
            500                 505                 510         
Phe Arg Ile Ala Ser Glu Leu Ala Gln His Ile Arg Met His Asn Gly
        515                 520                 525             
Glu Arg Pro Tyr Gln Cys Glu Asp Cys Gly Gln Ala Phe Thr Arg Ser
    530                 535                 540                 
Asn His Leu Gln Arg His Arg Ala Lys His Gly Thr Cys Lys Lys Glu
545                 550                 555                 560 
Pro Ile Pro Ser Ser Ser Asp Glu
                565             


<210> 8008
<211> 482
<212> PRT
<213> Homo sapiens

<400> 8008
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Glu His Ser Glu Cys Phe Leu Asn Pro
        435                 440                 445             
Cys Leu Ser Leu Pro Pro Ile Thr Gly Glu Lys Lys Ser Ala Phe Ala
    450                 455                 460                 
Thr Tyr Lys Val Lys Ala Ala Ala Ser Ala His Pro Leu Gln Met Glu
465                 470                 475                 480 
Ala Tyr
        


<210> 8009
<211> 596
<212> PRT
<213> Homo sapiens

<400> 8009
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Tyr
        115                 120                 125             
Leu Gln Met Lys Trp Pro Leu Leu Asp Val Gln Ala Gly Ser Leu Gln
    130                 135                 140                 
Ser Arg Gln Ala Leu Lys Asp Ala Arg Ser Pro Ser Pro Ala His Ile
145                 150                 155                 160 
Val Ser Asn Lys Val Pro Val Val Gln His Pro His His Val His Pro
                165                 170                 175     
Leu Thr Pro Leu Ile Thr Tyr Ser Asn Glu His Phe Thr Pro Gly Asn
            180                 185                 190         
Pro Pro Pro His Leu Pro Ala Asp Val Asp Pro Lys Thr Gly Ile Pro
        195                 200                 205             
Arg Pro Pro His Pro Pro Asp Ile Ser Pro Tyr Tyr Pro Leu Ser Pro
    210                 215                 220                 
Gly Thr Val Gly Gln Ile Pro His Pro Leu Gly Trp Leu Val Pro Gln
225                 230                 235                 240 
Gln Gly Gln Pro Val Tyr Pro Ile Thr Thr Gly Gly Phe Arg His Pro
                245                 250                 255     
Tyr Pro Thr Ala Leu Thr Val Asn Ala Ser Met Ser Arg Phe Pro Pro
            260                 265                 270         
His Met Val Pro Pro His His Thr Leu His Thr Thr Gly Ile Pro His
        275                 280                 285             
Pro Ala Ile Val Thr Pro Thr Val Lys Gln Glu Ser Ser Gln Ser Asp
    290                 295                 300                 
Val Gly Ser Leu His Ser Ser Lys His Gln Asp Ser Lys Lys Glu Glu
305                 310                 315                 320 
Glu Lys Lys Lys Pro His Ile Lys Lys Pro Leu Asn Ala Phe Met Leu
                325                 330                 335     
Tyr Met Lys Glu Met Arg Ala Lys Val Val Ala Glu Cys Thr Leu Lys
            340                 345                 350         
Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu
        355                 360                 365             
Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg
    370                 375                 380                 
Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr
385                 390                 395                 400 
Gly Lys Lys Lys Lys Arg Lys Arg Asp Lys Gln Pro Gly Glu Thr Asn
                405                 410                 415     
Glu His Ser Glu Cys Phe Leu Asn Pro Cys Leu Ser Leu Pro Pro Ile
            420                 425                 430         
Thr Asp Leu Ser Ala Pro Lys Lys Cys Arg Ala Arg Phe Gly Leu Asp
        435                 440                 445             
Gln Gln Asn Asn Trp Cys Gly Pro Cys Arg Arg Lys Lys Lys Cys Val
    450                 455                 460                 
Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu Ser Pro Pro Ser Ser Asp
465                 470                 475                 480 
Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser Pro Asn Leu Leu Gly Ser
                485                 490                 495     
Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu Gln Thr Gln Pro Leu Ser
            500                 505                 510         
Leu Ser Leu Lys Pro Asp Pro Leu Ala His Leu Ser Met Met Pro Pro
        515                 520                 525             
Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr His Lys Ala Ser Ala Leu
    530                 535                 540                 
Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro Ala Ala Leu Gln Pro Ala
545                 550                 555                 560 
Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser Thr Ser Ser Leu His Ser
                565                 570                 575     
His Ser Ser Leu Ala Gly Thr Gln Pro Gln Pro Leu Ser Leu Val Thr
            580                 585                 590         
Lys Ser Leu Glu
        595     


<210> 8010
<211> 602
<212> PRT
<213> Homo sapiens

<400> 8010
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Asp Ala Asn Thr Pro Lys Lys Cys Arg
        435                 440                 445             
Ala Leu Phe Gly Leu Asp Arg Gln Thr Leu Trp Cys Lys Pro Cys Arg
    450                 455                 460                 
Arg Lys Lys Lys Cys Val Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu
465                 470                 475                 480 
Ser Pro Pro Ser Ser Asp Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser
                485                 490                 495     
Pro Asn Leu Leu Gly Ser Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu
            500                 505                 510         
Gln Thr Gln Pro Leu Ser Leu Ser Leu Lys Pro Asp Pro Leu Ala His
        515                 520                 525             
Leu Ser Met Met Pro Pro Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr
    530                 535                 540                 
His Lys Ala Ser Ala Leu Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro
545                 550                 555                 560 
Ala Ala Leu Gln Pro Ala Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser
                565                 570                 575     
Thr Ser Ser Leu His Ser His Ser Ser Leu Ala Gly Thr Gln Pro Gln
            580                 585                 590         
Pro Leu Ser Leu Val Thr Lys Ser Leu Glu
        595                 600         


<210> 8011
<211> 619
<212> PRT
<213> Homo sapiens

<400> 8011
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Glu His Ser Glu Cys Phe Leu Asn Pro
        435                 440                 445             
Cys Leu Ser Leu Pro Pro Ile Thr Asp Leu Ser Ala Pro Lys Lys Cys
    450                 455                 460                 
Arg Ala Arg Phe Gly Leu Asp Gln Gln Asn Asn Trp Cys Gly Pro Cys
465                 470                 475                 480 
Arg Arg Lys Lys Lys Cys Val Arg Tyr Ile Gln Gly Glu Gly Ser Cys
                485                 490                 495     
Leu Ser Pro Pro Ser Ser Asp Gly Ser Leu Leu Asp Ser Pro Pro Pro
            500                 505                 510         
Ser Pro Asn Leu Leu Gly Ser Pro Pro Arg Asp Ala Lys Ser Gln Thr
        515                 520                 525             
Glu Gln Thr Gln Pro Leu Ser Leu Ser Leu Lys Pro Asp Pro Leu Ala
    530                 535                 540                 
His Leu Ser Met Met Pro Pro Pro Pro Ala Leu Leu Leu Ala Glu Ala
545                 550                 555                 560 
Thr His Lys Ala Ser Ala Leu Cys Pro Asn Gly Ala Leu Asp Leu Pro
                565                 570                 575     
Pro Ala Ala Leu Gln Pro Ala Ala Pro Ser Ser Ser Ile Ala Gln Pro
            580                 585                 590         
Ser Thr Ser Ser Leu His Ser His Ser Ser Leu Ala Gly Thr Gln Pro
        595                 600                 605             
Gln Pro Leu Ser Leu Val Thr Lys Ser Leu Glu
    610                 615                 


<210> 8012
<211> 465
<212> PRT
<213> Homo sapiens

<400> 8012
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Gly Glu Lys Lys Ser Ala Phe Ala Thr
        435                 440                 445             
Tyr Lys Val Lys Ala Ala Ala Ser Ala His Pro Leu Gln Met Glu Ala
    450                 455                 460                 
Tyr
465 


<210> 8013
<211> 602
<212> PRT
<213> Homo sapiens

<400> 8013
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Asp Leu Ser Ala Pro Lys Lys Cys Arg
        435                 440                 445             
Ala Arg Phe Gly Leu Asp Gln Gln Asn Asn Trp Cys Gly Pro Cys Arg
    450                 455                 460                 
Arg Lys Lys Lys Cys Val Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu
465                 470                 475                 480 
Ser Pro Pro Ser Ser Asp Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser
                485                 490                 495     
Pro Asn Leu Leu Gly Ser Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu
            500                 505                 510         
Gln Thr Gln Pro Leu Ser Leu Ser Leu Lys Pro Asp Pro Leu Ala His
        515                 520                 525             
Leu Ser Met Met Pro Pro Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr
    530                 535                 540                 
His Lys Ala Ser Ala Leu Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro
545                 550                 555                 560 
Ala Ala Leu Gln Pro Ala Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser
                565                 570                 575     
Thr Ser Ser Leu His Ser His Ser Ser Leu Ala Gly Thr Gln Pro Gln
            580                 585                 590         
Pro Leu Ser Leu Val Thr Lys Ser Leu Glu
        595                 600         


<210> 8014
<211> 477
<212> PRT
<213> Homo sapiens

<400> 8014
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Asp Leu Ser Ala Pro Lys Lys Cys Arg
        435                 440                 445             
Ala Arg Phe Gly Leu Asp Gln Gln Asn Asn Trp Cys Gly Pro Cys Arg
    450                 455                 460                 
Cys Lys Tyr Ser Lys Glu Val Ser Gly Thr Val Arg Ala
465                 470                 475         


<210> 8015
<211> 455
<212> PRT
<213> Homo sapiens

<400> 8015
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Tyr
        115                 120                 125             
Leu Gln Met Lys Trp Pro Leu Leu Asp Val Gln Ala Gly Ser Leu Gln
    130                 135                 140                 
Ser Arg Gln Ala Leu Lys Asp Ala Arg Ser Pro Ser Pro Ala His Ile
145                 150                 155                 160 
Val Ser Asn Lys Val Pro Val Val Gln His Pro His His Val His Pro
                165                 170                 175     
Leu Thr Pro Leu Ile Thr Tyr Ser Asn Glu His Phe Thr Pro Gly Asn
            180                 185                 190         
Pro Pro Pro His Leu Pro Ala Asp Val Asp Pro Lys Thr Gly Ile Pro
        195                 200                 205             
Arg Pro Pro His Pro Pro Asp Ile Ser Pro Tyr Tyr Pro Leu Ser Pro
    210                 215                 220                 
Gly Thr Val Gly Gln Ile Pro His Pro Leu Gly Trp Gln Gly Gln Pro
225                 230                 235                 240 
Val Tyr Pro Ile Thr Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala
                245                 250                 255     
Leu Thr Val Asn Ala Ser Met Ser Arg Phe Pro Pro His Met Val Pro
            260                 265                 270         
Pro His His Thr Leu His Thr Thr Gly Ile Pro His Pro Ala Ile Val
        275                 280                 285             
Thr Pro Thr Val Lys Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu
    290                 295                 300                 
His Ser Ser Lys His Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys
305                 310                 315                 320 
Pro His Ile Lys Lys Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu
                325                 330                 335     
Met Arg Ala Lys Val Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala
            340                 345                 350         
Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu
        355                 360                 365             
Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met
    370                 375                 380                 
Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys
385                 390                 395                 400 
Lys Arg Lys Arg Asp Lys Gln Pro Gly Glu Thr Asn Glu His Ser Glu
                405                 410                 415     
Cys Phe Leu Asn Pro Cys Leu Ser Leu Pro Pro Ile Thr Gly Glu Lys
            420                 425                 430         
Lys Ser Ala Phe Ala Thr Tyr Lys Val Lys Ala Ala Ala Ser Ala His
        435                 440                 445             
Pro Leu Gln Met Glu Ala Tyr
    450                 455 


<210> 8016
<211> 494
<212> PRT
<213> Homo sapiens

<400> 8016
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Glu His Ser Glu Cys Phe Leu Asn Pro
        435                 440                 445             
Cys Leu Ser Leu Pro Pro Ile Thr Asp Leu Ser Ala Pro Lys Lys Cys
    450                 455                 460                 
Arg Ala Arg Phe Gly Leu Asp Gln Gln Asn Asn Trp Cys Gly Pro Cys
465                 470                 475                 480 
Arg Cys Lys Tyr Ser Lys Glu Val Ser Gly Thr Val Arg Ala
                485                 490                 


<210> 8017
<211> 619
<212> PRT
<213> Homo sapiens

<400> 8017
Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp
 1               5                  10                  15      
Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser
            20                  25                  30          
Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu
        35                  40                  45              
Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala
    50                  55                  60                  
Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg
65                  70                  75                  80  
Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys
                85                  90                  95      
Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr
            100                 105                 110         
Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu
        115                 120                 125             
His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu
    130                 135                 140                 
His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp
145                 150                 155                 160 
Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg
                165                 170                 175     
Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln
            180                 185                 190         
His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn
        195                 200                 205             
Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val
    210                 215                 220                 
Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser
225                 230                 235                 240 
Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro
                245                 250                 255     
Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr
            260                 265                 270         
Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala
        275                 280                 285             
Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu
    290                 295                 300                 
His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys
305                 310                 315                 320 
Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His
                325                 330                 335     
Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys
            340                 345                 350         
Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val
        355                 360                 365             
Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu
    370                 375                 380                 
Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr
385                 390                 395                 400 
Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly
                405                 410                 415     
Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp
            420                 425                 430         
Lys Gln Pro Gly Glu Thr Asn Glu His Ser Glu Cys Phe Leu Asn Pro
        435                 440                 445             
Cys Leu Ser Leu Pro Pro Ile Thr Asp Ala Asn Thr Pro Lys Lys Cys
    450                 455                 460                 
Arg Ala Leu Phe Gly Leu Asp Arg Gln Thr Leu Trp Cys Lys Pro Cys
465                 470                 475                 480 
Arg Arg Lys Lys Lys Cys Val Arg Tyr Ile Gln Gly Glu Gly Ser Cys
                485                 490                 495     
Leu Ser Pro Pro Ser Ser Asp Gly Ser Leu Leu Asp Ser Pro Pro Pro
            500                 505                 510         
Ser Pro Asn Leu Leu Gly Ser Pro Pro Arg Asp Ala Lys Ser Gln Thr
        515                 520                 525             
Glu Gln Thr Gln Pro Leu Ser Leu Ser Leu Lys Pro Asp Pro Leu Ala
    530                 535                 540                 
His Leu Ser Met Met Pro Pro Pro Pro Ala Leu Leu Leu Ala Glu Ala
545                 550                 555                 560 
Thr His Lys Ala Ser Ala Leu Cys Pro Asn Gly Ala Leu Asp Leu Pro
                565                 570                 575     
Pro Ala Ala Leu Gln Pro Ala Ala Pro Ser Ser Ser Ile Ala Gln Pro
            580                 585                 590         
Ser Thr Ser Ser Leu His Ser His Ser Ser Leu Ala Gly Thr Gln Pro
        595                 600                 605             
Gln Pro Leu Ser Leu Val Thr Lys Ser Leu Glu
    610                 615                 


<210> 8018
<211> 408
<212> PRT
<213> Homo sapiens

<400> 8018
Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly
 1               5                  10                  15      
His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro
            20                  25                  30          
Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly
        35                  40                  45              
Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys
    50                  55                  60                  
Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro
65                  70                  75                  80  
Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val
                85                  90                  95      
Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp
            100                 105                 110         
Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr
        115                 120                 125             
Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln
    130                 135                 140                 
Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala
145                 150                 155                 160 
Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser
                165                 170                 175     
Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly
            180                 185                 190         
Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Asp Val Ser
        195                 200                 205             
Glu Gly Ser Val Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu
    210                 215                 220                 
Arg Lys His Leu Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala
225                 230                 235                 240 
Leu Asp Arg Val Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala
                245                 250                 255     
Ser Glu His Ile Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala
            260                 265                 270         
Leu Thr Pro Gly Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr
        275                 280                 285             
Asn Pro Glu Leu Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val
    290                 295                 300                 
Val Thr Gly Arg Asp Met Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro
305                 310                 315                 320 
His Val Pro Pro Thr Gly Gln Gly Ser Tyr Pro Thr Ser Thr Leu Ala
                325                 330                 335     
Gly Met Val Pro Gly Ser Glu Phe Ser Gly Asn Pro Tyr Ser His Pro
            340                 345                 350         
Gln Tyr Thr Ala Tyr Asn Glu Ala Trp Arg Phe Ser Asn Pro Ala Leu
        355                 360                 365             
Leu Met Pro Pro Pro Gly Pro Pro Leu Pro Leu Leu Pro Leu Pro Met
    370                 375                 380                 
Thr Ala Thr Ser Tyr Arg Gly Asp His Ile Lys Leu Gln Ala Asp Ser
385                 390                 395                 400 
Phe Gly Leu His Ile Val Pro Val
                405             


<210> 8019
<211> 393
<212> PRT
<213> Homo sapiens

<400> 8019
Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly
 1               5                  10                  15      
His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro
            20                  25                  30          
Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly
        35                  40                  45              
Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys
    50                  55                  60                  
Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro
65                  70                  75                  80  
Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val
                85                  90                  95      
Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp
            100                 105                 110         
Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr
        115                 120                 125             
Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln
    130                 135                 140                 
Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala
145                 150                 155                 160 
Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser
                165                 170                 175     
Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly
            180                 185                 190         
Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Asp Val Ser
        195                 200                 205             
Glu Gly Ser Val Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu
    210                 215                 220                 
Arg Lys His Leu Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala
225                 230                 235                 240 
Leu Asp Arg Val Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala
                245                 250                 255     
Ser Glu His Ile Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala
            260                 265                 270         
Leu Thr Pro Gly Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr
        275                 280                 285             
Asn Pro Glu Leu Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val
    290                 295                 300                 
Val Thr Gly Arg Asp Met Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro
305                 310                 315                 320 
His Val Pro Pro Thr Gly Gln Gly Ser Tyr Pro Thr Ser Thr Leu Ala
                325                 330                 335     
Gly Met Val Pro Gly Ser Glu Phe Ser Gly Asn Pro Tyr Ser His Pro
            340                 345                 350         
Gln Tyr Thr Ala Tyr Asn Glu Ala Trp Arg Phe Ser Asn Pro Ala Leu
        355                 360                 365             
Leu Ser Ser Pro Tyr Tyr Tyr Ser Ala Ala Pro Arg Ser Ala Pro Ala
    370                 375                 380                 
Ala Arg Ala Ala Ala Tyr Asp Arg His
385                 390             


<210> 8020
<211> 419
<212> PRT
<213> Homo sapiens

<400> 8020
Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly
 1               5                  10                  15      
His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro
            20                  25                  30          
Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly
        35                  40                  45              
Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys
    50                  55                  60                  
Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro
65                  70                  75                  80  
Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val
                85                  90                  95      
Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp
            100                 105                 110         
Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr
        115                 120                 125             
Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln
    130                 135                 140                 
Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala
145                 150                 155                 160 
Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser
                165                 170                 175     
Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly
            180                 185                 190         
Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Val Glu Val
        195                 200                 205             
Tyr Thr Asp Pro Ala His Ile Arg Gly Gly Gly Gly Leu His Leu Val
    210                 215                 220                 
Trp Thr Leu Arg Asp Val Ser Glu Gly Ser Val Pro Asn Gly Asp Ser
225                 230                 235                 240 
Gln Ser Gly Val Asp Ser Leu Arg Lys His Leu Arg Ala Asp Thr Phe
                245                 250                 255     
Thr Gln Gln Gln Leu Glu Ala Leu Asp Arg Val Phe Glu Arg Pro Ser
            260                 265                 270         
Tyr Pro Asp Val Phe Gln Ala Ser Glu His Ile Lys Ser Glu Gln Gly
        275                 280                 285             
Asn Glu Tyr Ser Leu Pro Ala Leu Thr Pro Gly Leu Asp Glu Val Lys
    290                 295                 300                 
Ser Ser Leu Ser Ala Ser Thr Asn Pro Glu Leu Gly Ser Asn Val Ser
305                 310                 315                 320 
Gly Thr Gln Thr Tyr Pro Val Val Thr Gly Arg Asp Met Ala Ser Thr
                325                 330                 335     
Thr Leu Pro Gly Tyr Pro Pro His Val Pro Pro Thr Gly Gln Gly Ser
            340                 345                 350         
Tyr Pro Thr Ser Thr Leu Ala Gly Met Val Pro Glu Ala Ala Val Gly
        355                 360                 365             
Pro Ser Ser Ser Leu Met Ser Lys Pro Gly Arg Lys Leu Ala Glu Val
    370                 375                 380                 
Pro Pro Cys Val Gln Pro Thr Gly Ala Ser Ser Pro Ala Thr Arg Thr
385                 390                 395                 400 
Ala Thr Pro Ser Thr Arg Pro Thr Thr Arg Leu Gly Asp Ser Ala Thr
                405                 410                 415     
Pro Pro Tyr
            


<210> 8021
<211> 431
<212> PRT
<213> Homo sapiens

<400> 8021
Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly
 1               5                  10                  15      
His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro
            20                  25                  30          
Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly
        35                  40                  45              
Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys
    50                  55                  60                  
Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro
65                  70                  75                  80  
Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val
                85                  90                  95      
Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp
            100                 105                 110         
Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr
        115                 120                 125             
Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln
    130                 135                 140                 
Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala
145                 150                 155                 160 
Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser
                165                 170                 175     
Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly
            180                 185                 190         
Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Val Glu Val
        195                 200                 205             
Tyr Thr Asp Pro Ala His Ile Arg Gly Gly Gly Gly Leu His Leu Val
    210                 215                 220                 
Trp Thr Leu Arg Asp Val Ser Glu Gly Ser Val Pro Asn Gly Asp Ser
225                 230                 235                 240 
Gln Ser Gly Val Asp Ser Leu Arg Lys His Leu Arg Ala Asp Thr Phe
                245                 250                 255     
Thr Gln Gln Gln Leu Glu Ala Leu Asp Arg Val Phe Glu Arg Pro Ser
            260                 265                 270         
Tyr Pro Asp Val Phe Gln Ala Ser Glu His Ile Lys Ser Glu Gln Gly
        275                 280                 285             
Asn Glu Tyr Ser Leu Pro Ala Leu Thr Pro Gly Leu Asp Glu Val Lys
    290                 295                 300                 
Ser Ser Leu Ser Ala Ser Thr Asn Pro Glu Leu Gly Ser Asn Val Ser
305                 310                 315                 320 
Gly Thr Gln Thr Tyr Pro Val Val Thr Gly Arg Asp Met Ala Ser Thr
                325                 330                 335     
Thr Leu Pro Gly Tyr Pro Pro His Val Pro Pro Thr Gly Gln Gly Ser
            340                 345                 350         
Tyr Pro Thr Ser Thr Leu Ala Gly Met Val Pro Gly Ser Glu Phe Ser
        355                 360                 365             
Gly Asn Pro Tyr Ser His Pro Gln Tyr Thr Ala Tyr Asn Glu Ala Trp
    370                 375                 380                 
Arg Phe Ser Asn Pro Ala Leu Leu Met Pro Pro Pro Gly Pro Pro Leu
385                 390                 395                 400 
Pro Leu Leu Pro Leu Pro Met Thr Ala Thr Ser Tyr Arg Gly Asp His
                405                 410                 415     
Ile Lys Leu Gln Ala Asp Ser Phe Gly Leu His Ile Val Pro Val
            420                 425                 430     


<210> 8022
<211> 417
<212> PRT
<213> Homo sapiens

<400> 8022
Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly
 1               5                  10                  15      
His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro
            20                  25                  30          
Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly
        35                  40                  45              
Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys
    50                  55                  60                  
Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro
65                  70                  75                  80  
Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val
                85                  90                  95      
Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp
            100                 105                 110         
Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr
        115                 120                 125             
Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln
    130                 135                 140                 
Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala
145                 150                 155                 160 
Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser
                165                 170                 175     
Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly
            180                 185                 190         
Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Val Glu Val
        195                 200                 205             
Tyr Thr Asp Pro Ala His Ile Arg Gly Gly Gly Gly Leu His Leu Val
    210                 215                 220                 
Trp Thr Leu Arg Asp Val Ser Glu Gly Ser Val Pro Asn Gly Asp Ser
225                 230                 235                 240 
Gln Ser Gly Val Asp Ser Leu Arg Lys His Leu Arg Ala Asp Thr Phe
                245                 250                 255     
Thr Gln Gln Gln Leu Glu Ala Leu Asp Arg Val Phe Glu Arg Pro Ser
            260                 265                 270         
Tyr Pro Asp Val Phe Gln Ala Ser Glu His Ile Lys Ser Glu Gln Gly
        275                 280                 285             
Asn Glu Tyr Ser Leu Pro Ala Leu Thr Pro Gly Leu Asp Glu Val Lys
    290                 295                 300                 
Ser Ser Leu Ser Ala Ser Thr Asn Pro Glu Leu Gly Ser Asn Val Ser
305                 310                 315                 320 
Gly Thr Gln Thr Tyr Pro Val Val Thr Gly Arg Asp Met Ala Ser Thr
                325                 330                 335     
Thr Leu Pro Gly Tyr Pro Pro His Val Pro Pro Thr Gly Gln Gly Ser
            340                 345                 350         
Tyr Pro Thr Ser Thr Leu Ala Gly Met Val Pro Gly Ser Glu Phe Ser
        355                 360                 365             
Gly Asn Pro Tyr Ser His Pro Gln Tyr Thr Ala Tyr Asn Glu Ala Trp
    370                 375                 380                 
Arg Phe Ser Asn Pro Ala Leu Leu Ser Ser Pro Tyr Tyr Tyr Ser Ala
385                 390                 395                 400 
Ala Pro Arg Gly Ser Ala Pro Ala Ala Ala Ala Ala Ala Tyr Asp Arg
                405                 410                 415     
His
    


<210> 8023
<211> 396
<212> PRT
<213> Homo sapiens

<400> 8023
Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly
 1               5                  10                  15      
His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro
            20                  25                  30          
Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly
        35                  40                  45              
Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys
    50                  55                  60                  
Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro
65                  70                  75                  80  
Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val
                85                  90                  95      
Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp
            100                 105                 110         
Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr
        115                 120                 125             
Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln
    130                 135                 140                 
Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala
145                 150                 155                 160 
Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser
                165                 170                 175     
Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly
            180                 185                 190         
Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Asp Val Ser
        195                 200                 205             
Glu Gly Ser Val Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu
    210                 215                 220                 
Arg Lys His Leu Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala
225                 230                 235                 240 
Leu Asp Arg Val Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala
                245                 250                 255     
Ser Glu His Ile Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala
            260                 265                 270         
Leu Thr Pro Gly Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr
        275                 280                 285             
Asn Pro Glu Leu Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val
    290                 295                 300                 
Val Thr Gly Arg Asp Met Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro
305                 310                 315                 320 
His Val Pro Pro Thr Gly Gln Gly Ser Tyr Pro Thr Ser Thr Leu Ala
                325                 330                 335     
Gly Met Val Pro Glu Ala Ala Val Gly Pro Ser Ser Ser Leu Met Ser
            340                 345                 350         
Lys Pro Gly Arg Lys Leu Ala Glu Val Pro Pro Cys Val Gln Pro Thr
        355                 360                 365             
Gly Ala Ser Ser Pro Ala Thr Arg Thr Ala Thr Pro Ser Thr Arg Pro
    370                 375                 380                 
Thr Thr Arg Leu Gly Asp Ser Ala Thr Pro Pro Tyr
385                 390                 395     


<210> 8024
<211> 828
<212> PRT
<213> Homo sapiens

<400> 8024
Met Ser Ser Lys Gln Ala Thr Ser Pro Phe Ala Cys Ala Ala Asp Gly
 1               5                  10                  15      
Glu Asp Ala Met Thr Gln Asp Leu Thr Ser Arg Glu Lys Glu Glu Gly
            20                  25                  30          
Ser Asp Gln His Val Ala Ser His Leu Pro Leu His Pro Ile Met His
        35                  40                  45              
Asn Lys Pro His Ser Glu Glu Leu Pro Thr Leu Val Ser Thr Ile Gln
    50                  55                  60                  
Gln Asp Ala Asp Trp Asp Ser Val Leu Ser Ser Gln Gln Arg Met Glu
65                  70                  75                  80  
Ser Glu Asn Asn Lys Leu Cys Ser Leu Tyr Ser Phe Arg Asn Thr Ser
                85                  90                  95      
Thr Ser Pro His Lys Pro Asp Glu Gly Ser Arg Asp Arg Glu Ile Met
            100                 105                 110         
Thr Ser Val Thr Phe Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala
        115                 120                 125             
Asp Val Val Asp Thr Leu Lys Gln Lys Lys Leu Glu Glu Met Thr Arg
    130                 135                 140                 
Thr Glu Gln Glu Asp Ser Ser Cys Met Glu Lys Leu Leu Ser Lys Asp
145                 150                 155                 160 
Trp Lys Glu Lys Met Glu Arg Leu Asn Thr Ser Glu Leu Leu Gly Glu
                165                 170                 175     
Ile Lys Gly Thr Pro Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Ser
            180                 185                 190         
Thr Met Ile Thr Gln Leu Ile Ser Leu Arg Glu Gln Leu Leu Ala Ala
        195                 200                 205             
His Asp Glu Gln Lys Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg
    210                 215                 220                 
Gln Gln Met Asp Leu Ala Arg Gln Gln Gln Glu Gln Ile Ala Arg Gln
225                 230                 235                 240 
Gln Gln Gln Leu Leu Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln
                245                 250                 255     
Gln Ile Gln Val Gln Gly His Met Pro Pro Leu Met Ile Pro Ile Phe
            260                 265                 270         
Pro His Asp Gln Arg Thr Leu Ala Ala Ala Ala Ala Ala Gln Gln Gly
        275                 280                 285             
Phe Leu Phe Pro Pro Gly Ile Thr Tyr Lys Pro Gly Asp Asn Tyr Pro
    290                 295                 300                 
Val Gln Phe Ile Pro Ser Thr Met Ala Ala Ala Ala Ala Ser Gly Leu
305                 310                 315                 320 
Ser Pro Leu Gln Leu Gln Lys Gly His Ala Ser His Pro Gln Ile Asn
                325                 330                 335     
Gln Arg Leu Lys Gly Leu Ser Asp Arg Phe Gly Arg Asn Leu Asp Thr
            340                 345                 350         
Phe Glu His Gly Gly Gly His Ser Tyr Asn His Lys Gln Ile Glu Gln
        355                 360                 365             
Leu Tyr Ala Ala Gln Leu Ala Ser Met Gln Val Ser Pro Gly Ala Lys
    370                 375                 380                 
Met Pro Ser Thr Pro Gln Pro Pro Asn Thr Ala Gly Thr Val Ser Pro
385                 390                 395                 400 
Thr Gly Ile Lys Asn Glu Lys Arg Gly Thr Ser Pro Val Thr Gln Val
                405                 410                 415     
Lys Asp Glu Ala Ala Ala Gln Pro Leu Asn Leu Ser Ser Arg Pro Lys
            420                 425                 430         
Thr Ala Glu Pro Val Lys Ser Pro Thr Ser Pro Thr Gln Asn Leu Phe
        435                 440                 445             
Pro Ala Ser Lys Thr Ser Pro Val Asn Leu Pro Asn Lys Ser Ser Ile
    450                 455                 460                 
Pro Ser Pro Ile Gly Gly Ser Leu Gly Arg Gly Ser Ser Leu Asp Ile
465                 470                 475                 480 
Leu Ser Ser Leu Asn Ser Pro Ala Leu Phe Gly Asp Gln Asp Thr Val
                485                 490                 495     
Met Lys Ala Ile Gln Glu Ala Arg Lys Met Arg Glu Gln Ile Gln Arg
            500                 505                 510         
Glu Gln Gln Gln Gln Gln Pro His Gly Val Asp Gly Lys Leu Ser Ser
        515                 520                 525             
Ile Asn Asn Met Gly Leu Asn Ser Cys Arg Asn Glu Lys Glu Arg Thr
    530                 535                 540                 
Arg Phe Glu Asn Leu Gly Pro Gln Leu Thr Gly Lys Ser Asn Glu Asp
545                 550                 555                 560 
Gly Lys Leu Gly Pro Gly Val Ile Asp Leu Thr Arg Pro Glu Asp Ala
                565                 570                 575     
Glu Gly Ser Lys Ala Met Asn Gly Ser Ala Ala Lys Leu Gln Gln Tyr
            580                 585                 590         
Tyr Cys Trp Pro Thr Gly Gly Ala Thr Val Ala Glu Ala Arg Val Tyr
        595                 600                 605             
Arg Asp Ala Arg Gly Arg Ala Ser Ser Glu Pro His Ile Lys Arg Pro
    610                 615                 620                 
Met Asn Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu
625                 630                 635                 640 
Gln Ala Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly
                645                 650                 655     
Ser Arg Trp Lys Ser Met Ser Asn Gln Glu Lys Gln Pro Tyr Tyr Glu
            660                 665                 670         
Glu Gln Ala Arg Leu Ser Lys Ile His Leu Glu Lys Tyr Pro Asn Tyr
        675                 680                 685             
Lys Tyr Lys Pro Arg Pro Lys Arg Thr Cys Ile Val Asp Gly Lys Lys
    690                 695                 700                 
Leu Arg Ile Gly Glu Tyr Lys Gln Leu Met Arg Ser Arg Arg Gln Glu
705                 710                 715                 720 
Met Arg Gln Phe Phe Thr Val Gly Gln Gln Pro Gln Ile Pro Ile Thr
                725                 730                 735     
Thr Gly Thr Gly Val Val Tyr Pro Gly Ala Ile Thr Met Ala Thr Thr
            740                 745                 750         
Thr Pro Ser Pro Gln Met Thr Ser Asp Cys Ser Ser Thr Ser Ala Ser
        755                 760                 765             
Pro Glu Pro Ser Leu Pro Val Ile Gln Ser Thr Tyr Gly Met Lys Thr
    770                 775                 780                 
Asp Gly Gly Ser Leu Ala Gly Asn Glu Met Ile Asn Gly Glu Asp Glu
785                 790                 795                 800 
Met Glu Met Tyr Asp Asp Tyr Glu Asp Asp Pro Lys Ser Asp Tyr Ser
                805                 810                 815     
Ser Glu Asn Glu Ala Pro Glu Ala Val Ser Ala Asn
            820                 825             


<210> 8025
<211> 841
<212> PRT
<213> Homo sapiens

<400> 8025
Met Lys Gly His Gly Glu Leu Gln Gly His Glu Arg Arg Met Ser Ser
 1               5                  10                  15      
Lys Gln Ala Thr Ser Pro Phe Ala Cys Ala Ala Asp Gly Glu Asp Ala
            20                  25                  30          
Met Thr Gln Asp Leu Thr Ser Arg Glu Lys Glu Glu Gly Ser Asp Gln
        35                  40                  45              
His Val Ala Ser His Leu Pro Leu His Pro Ile Met His Asn Lys Pro
    50                  55                  60                  
His Ser Glu Glu Leu Pro Thr Leu Val Ser Thr Ile Gln Gln Asp Ala
65                  70                  75                  80  
Asp Trp Asp Ser Val Leu Ser Ser Gln Gln Arg Met Glu Ser Glu Asn
                85                  90                  95      
Asn Lys Leu Cys Ser Leu Tyr Ser Phe Arg Asn Thr Ser Thr Ser Pro
            100                 105                 110         
His Lys Pro Asp Glu Gly Ser Arg Asp Arg Glu Ile Met Thr Ser Val
        115                 120                 125             
Thr Phe Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala Asp Val Val
    130                 135                 140                 
Asp Thr Leu Lys Gln Lys Lys Leu Glu Glu Met Thr Arg Thr Glu Gln
145                 150                 155                 160 
Glu Asp Ser Ser Cys Met Glu Lys Leu Leu Ser Lys Asp Trp Lys Glu
                165                 170                 175     
Lys Met Glu Arg Leu Asn Thr Ser Glu Leu Leu Gly Glu Ile Lys Gly
            180                 185                 190         
Thr Pro Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Ser Thr Met Ile
        195                 200                 205             
Thr Gln Leu Ile Ser Leu Arg Glu Gln Leu Leu Ala Ala His Asp Glu
    210                 215                 220                 
Gln Lys Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg Gln Gln Met
225                 230                 235                 240 
Asp Leu Ala Arg Gln Gln Gln Glu Gln Ile Ala Arg Gln Gln Gln Gln
                245                 250                 255     
Leu Leu Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln Gln Ile Gln
            260                 265                 270         
Val Gln Gly His Met Pro Pro Leu Met Ile Pro Ile Phe Pro His Asp
        275                 280                 285             
Gln Arg Thr Leu Ala Ala Ala Ala Ala Ala Gln Gln Gly Phe Leu Phe
    290                 295                 300                 
Pro Pro Gly Ile Thr Tyr Lys Pro Gly Asp Asn Tyr Pro Val Gln Phe
305                 310                 315                 320 
Ile Pro Ser Thr Met Ala Ala Ala Ala Ala Ser Gly Leu Ser Pro Leu
                325                 330                 335     
Gln Leu Gln Lys Gly His Val Ser His Pro Gln Ile Asn Gln Arg Leu
            340                 345                 350         
Lys Gly Leu Ser Asp Arg Phe Gly Arg Asn Leu Asp Thr Phe Glu His
        355                 360                 365             
Gly Gly Gly His Ser Tyr Asn His Lys Gln Ile Glu Gln Leu Tyr Ala
    370                 375                 380                 
Ala Gln Leu Ala Ser Met Gln Val Ser Pro Gly Ala Lys Met Pro Ser
385                 390                 395                 400 
Thr Pro Gln Pro Pro Asn Thr Ala Gly Thr Val Ser Pro Thr Gly Ile
                405                 410                 415     
Lys Asn Glu Lys Arg Gly Thr Ser Pro Val Thr Gln Val Lys Asp Glu
            420                 425                 430         
Ala Ala Ala Gln Pro Leu Asn Leu Ser Ser Arg Pro Lys Thr Ala Glu
        435                 440                 445             
Pro Val Lys Ser Pro Thr Ser Pro Thr Gln Asn Leu Phe Pro Ala Ser
    450                 455                 460                 
Lys Thr Ser Pro Val Asn Leu Pro Asn Lys Ser Ser Ile Pro Ser Pro
465                 470                 475                 480 
Ile Gly Gly Ser Leu Gly Arg Gly Ser Ser Leu Asp Ile Leu Ser Ser
                485                 490                 495     
Leu Asn Ser Pro Ala Leu Phe Gly Asp Gln Asp Thr Val Met Lys Ala
            500                 505                 510         
Ile Gln Glu Ala Arg Lys Met Arg Glu Gln Ile Gln Arg Glu Gln Gln
        515                 520                 525             
Gln Gln Gln Pro His Gly Val Asp Gly Lys Leu Ser Ser Ile Asn Asn
    530                 535                 540                 
Met Gly Leu Asn Ser Cys Arg Asn Glu Lys Glu Arg Thr Arg Phe Glu
545                 550                 555                 560 
Asn Leu Gly Pro Gln Leu Thr Gly Lys Ser Asn Glu Asp Gly Lys Leu
                565                 570                 575     
Gly Pro Gly Val Ile Asp Leu Thr Arg Pro Glu Asp Ala Glu Gly Ser
            580                 585                 590         
Lys Ala Met Asn Gly Ser Ala Ala Lys Leu Gln Gln Tyr Tyr Cys Trp
        595                 600                 605             
Pro Thr Gly Gly Ala Thr Val Ala Glu Ala Arg Val Tyr Arg Asp Ala
    610                 615                 620                 
Arg Gly Arg Ala Ser Ser Glu Pro His Ile Lys Arg Pro Met Asn Ala
625                 630                 635                 640 
Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln Ala Phe
                645                 650                 655     
Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser Arg Trp
            660                 665                 670         
Lys Ser Met Ser Asn Gln Glu Lys Gln Pro Tyr Tyr Glu Glu Gln Ala
        675                 680                 685             
Arg Leu Ser Lys Ile His Leu Glu Lys Tyr Pro Asn Tyr Lys Tyr Lys
    690                 695                 700                 
Pro Arg Pro Lys Arg Thr Cys Ile Val Asp Gly Lys Lys Leu Arg Ile
705                 710                 715                 720 
Gly Glu Tyr Lys Gln Leu Met Arg Ser Arg Arg Gln Glu Met Arg Gln
                725                 730                 735     
Phe Phe Thr Val Gly Gln Gln Pro Gln Ile Pro Ile Thr Thr Gly Thr
            740                 745                 750         
Gly Val Val Tyr Pro Gly Ala Ile Thr Met Ala Thr Thr Thr Pro Ser
        755                 760                 765             
Pro Gln Met Thr Ser Asp Cys Ser Ser Thr Ser Ala Ser Pro Glu Pro
    770                 775                 780                 
Ser Leu Pro Val Ile Gln Ser Thr Tyr Gly Met Lys Thr Asp Gly Gly
785                 790                 795                 800 
Ser Leu Ala Gly Asn Glu Met Ile Asn Gly Glu Asp Glu Met Glu Met
                805                 810                 815     
Tyr Asp Asp Tyr Glu Asp Asp Pro Lys Ser Asp Tyr Ser Ser Glu Asn
            820                 825                 830         
Glu Ala Pro Glu Ala Val Ser Ala Asn
        835                 840     


<210> 8026
<211> 808
<212> PRT
<213> Homo sapiens

<400> 8026
Met Ser Ser Lys Gln Ala Thr Ser Pro Phe Ala Cys Ala Ala Asp Gly
 1               5                  10                  15      
Glu Asp Ala Met Thr Gln Asp Leu Thr Ser Arg Glu Lys Glu Glu Gly
            20                  25                  30          
Ser Asp Gln His Val Ala Ser His Leu Pro Leu His Pro Ile Met His
        35                  40                  45              
Asn Lys Pro His Ser Glu Glu Leu Pro Thr Leu Val Ser Thr Ile Gln
    50                  55                  60                  
Gln Asp Ala Asp Trp Asp Ser Val Leu Ser Ser Gln Gln Arg Met Glu
65                  70                  75                  80  
Ser Glu Asn Asn Lys Leu Cys Ser Leu Tyr Ser Phe Arg Asn Thr Ser
                85                  90                  95      
Thr Ser Pro His Lys Pro Asp Glu Gly Ser Arg Asp Arg Glu Ile Met
            100                 105                 110         
Thr Ser Val Thr Phe Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala
        115                 120                 125             
Asp Val Val Asp Thr Leu Lys Gln Lys Lys Leu Glu Glu Met Thr Arg
    130                 135                 140                 
Thr Glu Gln Glu Asp Ser Ser Cys Met Glu Lys Leu Leu Ser Lys Asp
145                 150                 155                 160 
Trp Lys Glu Lys Met Glu Arg Leu Asn Thr Ser Glu Leu Leu Gly Glu
                165                 170                 175     
Ile Lys Gly Thr Pro Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Ser
            180                 185                 190         
Thr Met Ile Thr Gln Leu Ile Ser Leu Arg Glu Gln Leu Leu Ala Ala
        195                 200                 205             
His Asp Glu Gln Lys Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg
    210                 215                 220                 
Gln Gln Met Asp Leu Ala Arg Gln Gln Gln Glu Gln Ile Ala Arg Gln
225                 230                 235                 240 
Gln Gln Gln Leu Leu Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln
                245                 250                 255     
Gln Ile Gln Val Gln Gly His Met Pro Pro Leu Met Ile Pro Ile Phe
            260                 265                 270         
Pro His Asp Gln Arg Thr Leu Ala Ala Ala Ala Ala Ala Gln Gln Gly
        275                 280                 285             
Phe Leu Phe Pro Pro Gly Ile Thr Tyr Lys Pro Gly Asp Asn Tyr Pro
    290                 295                 300                 
Val Gln Phe Ile Pro Ser Thr Met Ala Ala Ala Ala Ala Ser Gly Leu
305                 310                 315                 320 
Ser Pro Leu Gln Leu Gln Lys Gly His Ala Ser His Pro Gln Ile Asn
                325                 330                 335     
Gln Arg Leu Lys Gly Leu Ser Asp Arg Phe Gly Arg Asn Leu Asp Thr
            340                 345                 350         
Phe Glu His Gly Gly Gly His Ser Tyr Asn His Lys Gln Ile Glu Gln
        355                 360                 365             
Leu Tyr Ala Ala Gln Leu Ala Ser Met Gln Val Ser Pro Gly Ala Lys
    370                 375                 380                 
Met Pro Ser Thr Pro Gln Pro Pro Asn Thr Ala Gly Thr Val Ser Pro
385                 390                 395                 400 
Thr Gly Ile Lys Asn Glu Lys Arg Gly Thr Ser Pro Val Thr Gln Val
                405                 410                 415     
Lys Asp Glu Ala Ala Ala Gln Pro Leu Asn Leu Ser Ser Arg Pro Lys
            420                 425                 430         
Thr Ala Glu Pro Val Lys Ser Pro Thr Ser Pro Thr Gln Asn Leu Phe
        435                 440                 445             
Pro Ala Ser Lys Thr Ser Pro Val Asn Leu Pro Asn Lys Ser Ser Ile
    450                 455                 460                 
Pro Ser Pro Ile Gly Gly Ser Leu Gly Arg Gly Ser Ser Leu Asp Ile
465                 470                 475                 480 
Leu Ser Ser Leu Asn Ser Pro Ala Leu Phe Gly Asp Gln Asp Thr Val
                485                 490                 495     
Met Lys Ala Ile Gln Glu Ala Arg Lys Met Arg Glu Gln Ile Gln Arg
            500                 505                 510         
Glu Gln Gln Gln Gln Gln Pro His Gly Val Asp Gly Lys Leu Ser Ser
        515                 520                 525             
Ile Asn Asn Met Gly Leu Asn Ser Cys Arg Asn Glu Lys Glu Arg Thr
    530                 535                 540                 
Arg Phe Glu Asn Leu Gly Pro Gln Leu Thr Gly Lys Ser Asn Glu Asp
545                 550                 555                 560 
Gly Lys Leu Gly Pro Gly Val Ile Asp Leu Thr Arg Pro Glu Asp Ala
                565                 570                 575     
Glu Gly Gly Ala Thr Val Ala Glu Ala Arg Val Tyr Arg Asp Ala Arg
            580                 585                 590         
Gly Arg Ala Ser Ser Glu Pro His Ile Lys Arg Pro Met Asn Ala Phe
        595                 600                 605             
Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln Ala Phe Pro
    610                 615                 620                 
Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser Arg Trp Lys
625                 630                 635                 640 
Ser Met Ser Asn Gln Glu Lys Gln Pro Tyr Tyr Glu Glu Gln Ala Arg
                645                 650                 655     
Leu Ser Lys Ile His Leu Glu Lys Tyr Pro Asn Tyr Lys Tyr Lys Pro
            660                 665                 670         
Arg Pro Lys Arg Thr Cys Ile Val Asp Gly Lys Lys Leu Arg Ile Gly
        675                 680                 685             
Glu Tyr Lys Gln Leu Met Arg Ser Arg Arg Gln Glu Met Arg Gln Phe
    690                 695                 700                 
Phe Thr Val Gly Gln Gln Pro Gln Ile Pro Ile Thr Thr Gly Thr Gly
705                 710                 715                 720 
Val Val Tyr Pro Gly Ala Ile Thr Met Ala Thr Thr Thr Pro Ser Pro
                725                 730                 735     
Gln Met Thr Ser Asp Cys Ser Ser Thr Ser Ala Ser Pro Glu Pro Ser
            740                 745                 750         
Leu Pro Val Ile Gln Ser Thr Tyr Gly Met Lys Thr Asp Gly Gly Ser
        755                 760                 765             
Leu Ala Gly Asn Glu Met Ile Asn Gly Glu Asp Glu Met Glu Met Tyr
    770                 775                 780                 
Asp Asp Tyr Glu Asp Asp Pro Lys Ser Asp Tyr Ser Ser Glu Asn Glu
785                 790                 795                 800 
Ala Pro Glu Ala Val Ser Ala Asn
                805             


<210> 8027
<211> 247
<212> PRT
<213> Homo sapiens

<400> 8027
Met Asn Val Asn Ala Pro Pro Gln Ala Leu Thr Cys Leu Thr Cys His
 1               5                  10                  15      
Cys His Val Glu Gln Lys Ser Pro Ile Ile Pro Glu Cys Ser Thr Asn
            20                  25                  30          
Val Gln Thr Ala Ala Gly Gly Ser Asn Ser Ser Gln Tyr Asn Ser Asn
        35                  40                  45              
Leu Thr Ile Arg Leu Ser Val Ser Trp Lys Gly Gln Ser Lys Ser Thr
    50                  55                  60                  
Val Gly Thr Val Phe Ser Leu Glu Ser Glu Glu Glu Glu Tyr Pro Gly
65                  70                  75                  80  
Ile Thr Ala Glu Asp Ser Asn Asp Ile Tyr Ile Leu Pro Ser Asp Asn
                85                  90                  95      
Ser Gly Gln Val Ser Pro Pro Glu Ser Pro Thr Val Thr Thr Ser Trp
            100                 105                 110         
Gln Ser Glu Ser Leu Pro Val Ser Leu Ser Ala Ser Gln Ser Trp His
        115                 120                 125             
Thr Glu Ser Leu Pro Val Ser Leu Gly Pro Glu Ser Trp Gln Gln Ile
    130                 135                 140                 
Ala Met Asp Pro Glu Glu Val Lys Ser Leu Asp Ser Asn Gly Ala Gly
145                 150                 155                 160 
Glu Lys Ser Glu Asn Asn Ser Ser Asn Ser Asp Ile Val His Val Glu
                165                 170                 175     
Lys Glu Glu Val Pro Glu Gly Met Glu Glu Ala Ala Val Ala Ser Val
            180                 185                 190         
Val Leu Pro Ala Arg Asn Cys Lys Arg His Phe Leu Lys Pro Gln Leu
        195                 200                 205             
Leu Ala Ser His Ile Thr Ala Leu Leu Leu Gly Thr Arg Glu Pro Asp
    210                 215                 220                 
Thr Glu Val Ile Thr Val Glu Lys Ser Ser Pro Ala Thr Ser Leu Phe
225                 230                 235                 240 
Val Asp Leu Met Lys Lys Arg
                245         


<210> 8028
<211> 1110
<212> PRT
<213> Homo sapiens

<400> 8028
Arg Gly Pro Val Ala Ala Ala Gly Thr Met Asp Arg Ala Pro Thr Glu
 1               5                  10                  15      
Gln Asn Val Lys Leu Ser Ala Glu Val Glu Pro Phe Ile Pro Gln Lys
            20                  25                  30          
Lys Ser Pro Asp Thr Phe Met Ile Pro Met Ala Leu Pro Asn Asp Asn
        35                  40                  45              
Gly Ser Val Ser Gly Val Glu Pro Thr Pro Ile Pro Ser Tyr Leu Ile
    50                  55                  60                  
Thr Cys Tyr Pro Phe Val Gln Glu Asn Gln Ser Asn Arg Gln Phe Pro
65                  70                  75                  80  
Leu Tyr Asn Asn Asp Ile Arg Trp Gln Gln Pro Asn Pro Asn Pro Thr
                85                  90                  95      
Gly Pro Tyr Phe Ala Tyr Pro Ile Ile Ser Ala Gln Pro Pro Val Ser
            100                 105                 110         
Thr Glu Tyr Thr Tyr Tyr Gln Leu Met Pro Ala Pro Cys Ala Gln Val
        115                 120                 125             
Met Gly Phe Tyr His Pro Phe Pro Thr Pro Tyr Ser Asn Thr Phe Gln
    130                 135                 140                 
Ala Ala Asn Thr Val Asn Ala Ile Thr Thr Glu Cys Thr Glu Arg Pro
145                 150                 155                 160 
Ser Gln Leu Gly Gln Val Phe Pro Leu Ser Ser His Arg Ser Arg Asn
                165                 170                 175     
Ser Asn Arg Gly Ser Val Val Pro Lys Gln Gln Leu Leu Gln Gln His
            180                 185                 190         
Ile Lys Ser Lys Arg Pro Leu Val Lys Asn Val Ala Thr Gln Lys Glu
        195                 200                 205             
Thr Asn Ala Ala Gly Pro Asp Ser Arg Ser Lys Ile Val Leu Leu Val
    210                 215                 220                 
Asp Ala Ser Gln Gln Thr Asp Phe Pro Ser Asp Ile Ala Asn Lys Ser
225                 230                 235                 240 
Leu Ser Glu Thr Thr Ala Thr Met Leu Trp Lys Ser Lys Gly Arg Arg
                245                 250                 255     
Arg Arg Ala Ser His Pro Thr Ala Glu Ser Ser Ser Glu Gln Gly Ala
            260                 265                 270         
Ser Glu Ala Asp Ile Asp Ser Asp Ser Gly Tyr Cys Ser Pro Lys His
        275                 280                 285             
Ser Asn Asn Gln Pro Ala Ala Gly Ala Leu Arg Asn Pro Asp Ser Gly
    290                 295                 300                 
Thr Met Asn His Val Glu Ser Ser Met Cys Ala Gly Gly Val Asn Trp
305                 310                 315                 320 
Ser Asn Val Thr Cys Gln Ala Thr Gln Lys Lys Pro Trp Met Glu Lys
                325                 330                 335     
Asn Gln Thr Phe Ser Arg Gly Gly Arg Gln Thr Glu Gln Arg Asn Asn
            340                 345                 350         
Ser Gln Val Gly Phe Arg Cys Arg Gly His Ser Thr Ser Ser Glu Arg
        355                 360                 365             
Arg Gln Asn Leu Gln Lys Arg Pro Asp Asn Lys His Leu Ser Ser Ser
    370                 375                 380                 
Gln Ser His Arg Ser Asp Pro Asn Ser Glu Ser Leu Tyr Phe Glu Asp
385                 390                 395                 400 
Glu Asp Gly Phe Gln Glu Leu Asn Glu Asn Gly Asn Ala Lys Asp Glu
                405                 410                 415     
Asn Ile Gln Gln Lys Leu Ser Ser Lys Val Leu Asp Asp Leu Pro Glu
            420                 425                 430         
Asn Ser Pro Ile Asn Ile Val Gln Thr Pro Ile Pro Ile Thr Thr Ser
        435                 440                 445             
Val Pro Lys Arg Ala Lys Ser Gln Lys Lys Lys Ala Leu Ala Ala Ala
    450                 455                 460                 
Leu Ala Thr Ala Gln Glu Tyr Ser Glu Ile Ser Met Glu Gln Lys Lys
465                 470                 475                 480 
Leu Gln Glu Ala Leu Ser Lys Ala Ala Gly Lys Lys Asn Lys Thr Pro
                485                 490                 495     
Val Gln Leu Asp Leu Gly Asp Met Leu Ala Ala Leu Glu Lys Gln Gln
            500                 505                 510         
Gln Ala Met Lys Ala Arg Gln Ile Thr Asn Thr Arg Pro Leu Ser Tyr
        515                 520                 525             
Thr Val Val Thr Ala Ala Ser Phe His Thr Lys Asp Ser Thr Asn Arg
    530                 535                 540                 
Lys Pro Leu Thr Lys Ser Gln Pro Cys Leu Thr Ser Phe Asn Ser Val
545                 550                 555                 560 
Asp Ile Ala Ser Ser Lys Ala Lys Lys Gly Lys Glu Lys Glu Ile Ala
                565                 570                 575     
Lys Leu Lys Arg Pro Thr Ala Leu Lys Lys Val Ile Leu Lys Glu Arg
            580                 585                 590         
Glu Glu Lys Lys Gly Arg Leu Thr Val Asp His Asn Leu Leu Gly Ser
        595                 600                 605             
Glu Glu Pro Thr Glu Met His Leu Asp Phe Ile Asp Asp Leu Pro Gln
    610                 615                 620                 
Glu Ile Val Ser Gln Glu Asp Thr Gly Leu Ser Met Pro Ser Asp Thr
625                 630                 635                 640 
Ser Leu Ser Pro Ala Ser Gln Asn Ser Pro Tyr Cys Met Thr Pro Val
                645                 650                 655     
Ser Gln Gly Ser Pro Ala Ser Ser Gly Ile Gly Ser Pro Met Ala Ser
            660                 665                 670         
Ser Thr Ile Thr Lys Ile His Ser Lys Arg Phe Arg Glu Tyr Cys Asn
        675                 680                 685             
Gln Val Leu Cys Lys Glu Ile Asp Glu Cys Val Thr Leu Leu Leu Gln
    690                 695                 700                 
Glu Leu Val Ser Phe Gln Glu Arg Ile Tyr Gln Lys Asp Pro Val Arg
705                 710                 715                 720 
Ala Lys Ala Arg Arg Arg Leu Val Met Gly Leu Arg Glu Val Thr Lys
                725                 730                 735     
His Met Lys Leu Asn Lys Ile Lys Cys Val Ile Ile Ser Pro Asn Cys
            740                 745                 750         
Glu Lys Ile Gln Ser Lys Gly Gly Leu Asp Glu Ala Leu Tyr Asn Val
        755                 760                 765             
Ile Ala Met Ala Arg Glu Gln Glu Ile Pro Phe Val Phe Ala Leu Gly
    770                 775                 780                 
Arg Lys Ala Leu Gly Arg Cys Val Asn Lys Leu Val Pro Val Ser Val
785                 790                 795                 800 
Val Gly Ile Phe Asn Tyr Phe Gly Ala Glu Ser Leu Phe Asn Lys Leu
                805                 810                 815     
Val Glu Leu Thr Glu Glu Ala Arg Lys Ala Tyr Lys Asp Met Val Ala
            820                 825                 830         
Ala Met Glu Gln Glu Gln Ala Glu Glu Ala Leu Lys Asn Val Lys Lys
        835                 840                 845             
Val Pro His His Met Gly His Ser Arg Asn Pro Ser Ala Ala Ser Ala
    850                 855                 860                 
Ile Ser Phe Cys Ser Val Ile Ser Glu Pro Ile Ser Glu Val Asn Glu
865                 870                 875                 880 
Lys Glu Tyr Glu Thr Asn Trp Arg Asn Met Val Glu Thr Ser Asp Gly
                885                 890                 895     
Leu Glu Ala Ser Glu Asn Glu Lys Glu Val Ser Cys Lys His Ser Thr
            900                 905                 910         
Ser Glu Lys Pro Ser Lys Leu Pro Phe Asp Thr Pro Pro Ile Gly Lys
        915                 920                 925             
Gln Pro Ser Leu Val Ala Thr Gly Ser Thr Thr Ser Ala Thr Ser Ala
    930                 935                 940                 
Gly Lys Ser Thr Ala Ser Asp Lys Glu Glu Val Lys Pro Asp Asp Leu
945                 950                 955                 960 
Glu Trp Ala Ser Gln Gln Ser Thr Glu Thr Gly Ser Leu Asp Gly Ser
                965                 970                 975     
Cys Arg Asp Leu Leu Asn Ser Ser Ile Thr Ser Thr Thr Ser Thr Leu
            980                 985                 990         
Val Pro Gly Met Leu Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu
        995                 1000                1005            
Glu Asp Tyr Thr His Glu Pro Ile Ser Val Glu Val Gln Leu Asn Ser
    1010                1015                1020                
Arg Ile Glu Ser Trp Val Ser Glu Thr Gln Arg Thr Met Glu Thr Leu
1025                1030                1035                1040
Gln Leu Gly Lys Thr Leu Asn Gly Ser Glu Glu Asp Asn Val Glu Gln
                1045                1050                1055    
Ser Gly Glu Glu Glu Ala Glu Ala Pro Glu Val Leu Glu Pro Gly Met
            1060                1065                1070        
Asp Ser Glu Ala Trp Thr Ala Asp Gln Gln Ala Ser Pro Gly Gln Gln
        1075                1080                1085            
Lys Ser Ser Asn Cys Ser Ser Leu Asn Lys Glu His Ser Asp Ser Asn
    1090                1095                1100                
Tyr Thr Thr Gln Thr Thr
1105                1110


<210> 8029
<211> 345
<212> PRT
<213> Homo sapiens

<400> 8029
Met Glu Pro Leu Arg Val Leu Glu Leu Tyr Ser Gly Val Gly Gly Met
 1               5                  10                  15      
His His Ala Leu Arg Glu Ser Cys Ile Pro Ala Gln Val Val Ala Ala
            20                  25                  30          
Ile Asp Val Asn Thr Val Ala Asn Glu Val Tyr Lys Tyr Asn Phe Pro
        35                  40                  45              
His Thr Gln Leu Leu Ala Lys Thr Ile Glu Gly Ile Thr Leu Glu Glu
    50                  55                  60                  
Phe Asp Arg Leu Ser Phe Asp Met Ile Leu Met Ser Pro Pro Cys Gln
65                  70                  75                  80  
Pro Phe Thr Arg Asp Leu Leu Ile Gln Thr Ile Glu Asn Cys Gly Phe
                85                  90                  95      
Gln Tyr Gln Glu Phe Leu Leu Ser Pro Thr Ser Leu Gly Ile Pro Asn
            100                 105                 110         
Ser Arg Leu Arg Tyr Phe Leu Ile Ala Lys Leu Gln Ser Glu Pro Leu
        115                 120                 125             
Pro Phe Gln Ala Pro Gly Gln Val Leu Met Glu Phe Pro Lys Ile Glu
    130                 135                 140                 
Ser Val His Pro Gln Lys Tyr Ala Met Asp Val Glu Asn Lys Ile Gln
145                 150                 155                 160 
Glu Lys Asn Val Glu Pro Asn Ile Ser Phe Asp Gly Ser Ile Gln Cys
                165                 170                 175     
Ser Gly Lys Asp Ala Ile Leu Phe Lys Leu Glu Thr Ala Glu Glu Ile
            180                 185                 190         
His Arg Lys Asn Gln Gln Asp Ser Asp Leu Ser Val Lys Met Leu Lys
        195                 200                 205             
Asp Phe Leu Glu Asp Asp Thr Asp Val Asn Gln Tyr Leu Leu Pro Pro
    210                 215                 220                 
Lys Ser Leu Leu Arg Tyr Ala Leu Leu Leu Asp Ile Val Gln Pro Thr
225                 230                 235                 240 
Cys Arg Arg Ser Val Cys Phe Thr Lys Gly Tyr Gly Ser Tyr Ile Glu
                245                 250                 255     
Gly Thr Gly Ser Val Leu Gln Thr Ala Glu Asp Val Gln Val Glu Asn
            260                 265                 270         
Ile Tyr Lys Ser Leu Thr Asn Leu Ser Gln Glu Glu Gln Ile Thr Lys
        275                 280                 285             
Leu Leu Ile Leu Lys Leu Arg Tyr Phe Thr Pro Lys Glu Ile Ala Asn
    290                 295                 300                 
Leu Leu Gly Phe Pro Pro Glu Phe Gly Phe Pro Glu Lys Ile Thr Val
305                 310                 315                 320 
Lys Gln Arg Tyr Arg Leu Leu Gly Asn Ser Leu Asn Val His Val Val
                325                 330                 335     
Ala Lys Leu Ile Lys Ile Leu Tyr Glu
            340                 345 


<210> 8030
<211> 367
<212> PRT
<213> Homo sapiens

<400> 8030
Met Glu Pro Leu Arg Val Leu Glu Leu Tyr Ser Gly Val Gly Gly Met
 1               5                  10                  15      
His His Ala Leu Arg Glu Ser Cys Ile Pro Ala Gln Val Val Ala Ala
            20                  25                  30          
Ile Asp Val Asn Thr Val Ala Asn Glu Val Tyr Lys Tyr Asn Phe Pro
        35                  40                  45              
His Thr Gln Leu Leu Ala Lys Thr Ile Glu Gly Ile Thr Leu Glu Glu
    50                  55                  60                  
Phe Asp Arg Leu Ser Phe Asp Met Ile Leu Met Ser Pro Pro Cys Gln
65                  70                  75                  80  
Pro Phe Thr Arg Leu Gln Lys Leu Pro Lys Tyr Ile Leu Leu Glu Asn
                85                  90                  95      
Val Lys Gly Phe Glu Val Ser Ser Thr Arg Asp Leu Leu Ile Gln Thr
            100                 105                 110         
Ile Glu Asn Cys Gly Phe Gln Tyr Gln Glu Phe Leu Leu Ser Pro Thr
        115                 120                 125             
Ser Leu Gly Ile Pro Asn Ser Arg Leu Arg Tyr Phe Leu Ile Ala Lys
    130                 135                 140                 
Leu Gln Ser Glu Pro Leu Pro Phe Gln Ala Pro Gly Gln Val Leu Met
145                 150                 155                 160 
Glu Phe Pro Lys Ile Glu Ser Val His Pro Gln Lys Tyr Ala Met Asp
                165                 170                 175     
Val Glu Asn Lys Ile Gln Glu Lys Asn Val Glu Pro Asn Ile Ser Phe
            180                 185                 190         
Asp Gly Ser Ile Gln Cys Ser Gly Lys Asp Ala Ile Leu Phe Lys Leu
        195                 200                 205             
Glu Thr Ala Glu Glu Ile His Arg Lys Asn Gln Gln Asp Ser Asp Leu
    210                 215                 220                 
Ser Val Lys Met Leu Lys Asp Phe Leu Glu Asp Asp Thr Asp Val Asn
225                 230                 235                 240 
Gln Tyr Leu Leu Pro Pro Lys Ser Leu Leu Arg Tyr Ala Leu Leu Leu
                245                 250                 255     
Asp Ile Val Gln Pro Thr Cys Arg Arg Ser Val Cys Phe Thr Lys Gly
            260                 265                 270         
Tyr Gly Ser Tyr Ile Glu Gly Thr Gly Ser Val Leu Gln Thr Ala Glu
        275                 280                 285             
Asp Val Gln Val Glu Asn Ile Tyr Lys Ser Leu Thr Asn Leu Ser Gln
    290                 295                 300                 
Glu Glu Gln Ile Thr Lys Leu Leu Ile Leu Lys Leu Arg Tyr Phe Thr
305                 310                 315                 320 
Pro Lys Glu Ile Ala Asn Leu Leu Gly Phe Pro Pro Glu Phe Gly Phe
                325                 330                 335     
Pro Glu Lys Ile Thr Val Lys Gln Arg Tyr Arg Leu Leu Gly Asn Ser
            340                 345                 350         
Leu Asn Val His Val Val Ala Lys Leu Ile Lys Ile Leu Tyr Glu
        355                 360                 365         


<210> 8031
<211> 391
<212> PRT
<213> Homo sapiens

<400> 8031
Met Glu Pro Leu Arg Val Leu Glu Leu Tyr Ser Gly Val Gly Gly Met
 1               5                  10                  15      
His His Ala Leu Arg Glu Ser Cys Ile Pro Ala Gln Val Val Ala Ala
            20                  25                  30          
Ile Asp Val Asn Thr Val Ala Asn Glu Val Tyr Lys Tyr Asn Phe Pro
        35                  40                  45              
His Thr Gln Leu Leu Ala Lys Thr Ile Glu Gly Ile Thr Leu Glu Glu
    50                  55                  60                  
Phe Asp Arg Leu Ser Phe Asp Met Ile Leu Met Ser Pro Pro Cys Gln
65                  70                  75                  80  
Pro Phe Thr Arg Ile Gly Arg Gln Gly Asp Met Thr Asp Ser Arg Thr
                85                  90                  95      
Asn Ser Phe Leu His Ile Leu Asp Ile Leu Pro Arg Leu Gln Lys Leu
            100                 105                 110         
Pro Lys Tyr Ile Leu Leu Glu Asn Val Lys Gly Phe Glu Val Ser Ser
        115                 120                 125             
Thr Arg Asp Leu Leu Ile Gln Thr Ile Glu Asn Cys Gly Phe Gln Tyr
    130                 135                 140                 
Gln Glu Phe Leu Leu Ser Pro Thr Ser Leu Gly Ile Pro Asn Ser Arg
145                 150                 155                 160 
Leu Arg Tyr Phe Leu Ile Ala Lys Leu Gln Ser Glu Pro Leu Pro Phe
                165                 170                 175     
Gln Ala Pro Gly Gln Val Leu Met Glu Phe Pro Lys Ile Glu Ser Val
            180                 185                 190         
His Pro Gln Lys Tyr Ala Met Asp Val Glu Asn Lys Ile Gln Glu Lys
        195                 200                 205             
Asn Val Glu Pro Asn Ile Ser Phe Asp Gly Ser Ile Gln Cys Ser Gly
    210                 215                 220                 
Lys Asp Ala Ile Leu Phe Lys Leu Glu Thr Ala Glu Glu Ile His Arg
225                 230                 235                 240 
Lys Asn Gln Gln Asp Ser Asp Leu Ser Val Lys Met Leu Lys Asp Phe
                245                 250                 255     
Leu Glu Asp Asp Thr Asp Val Asn Gln Tyr Leu Leu Pro Pro Lys Ser
            260                 265                 270         
Leu Leu Arg Tyr Ala Leu Leu Leu Asp Ile Val Gln Pro Thr Cys Arg
        275                 280                 285             
Arg Ser Val Cys Phe Thr Lys Gly Tyr Gly Ser Tyr Ile Glu Gly Thr
    290                 295                 300                 
Gly Ser Val Leu Gln Thr Ala Glu Asp Val Gln Val Glu Asn Ile Tyr
305                 310                 315                 320 
Lys Ser Leu Thr Asn Leu Ser Gln Glu Glu Gln Ile Thr Lys Leu Leu
                325                 330                 335     
Ile Leu Lys Leu Arg Tyr Phe Thr Pro Lys Glu Ile Ala Asn Leu Leu
            340                 345                 350         
Gly Phe Pro Pro Glu Phe Gly Phe Pro Glu Lys Ile Thr Val Lys Gln
        355                 360                 365             
Arg Tyr Arg Leu Leu Gly Asn Ser Leu Asn Val His Val Val Ala Lys
    370                 375                 380                 
Leu Ile Lys Ile Leu Tyr Glu
385                 390     


<210> 8032
<211> 291
<212> PRT
<213> Homo sapiens

<400> 8032
Met Glu Ala Pro Ala Ser Ala Gln Thr Pro His Pro His Glu Pro Ile
 1               5                  10                  15      
Ser Phe Gly Ile Asp Gln Ile Leu Asn Ser Pro Asp Gln Asp Ser Ala
            20                  25                  30          
Pro Ala Pro Arg Gly Pro Asp Gly Ala Ser Tyr Leu Gly Gly Pro Pro
        35                  40                  45              
Gly Gly Arg Pro Gly Ala Thr Tyr Pro Ser Leu Pro Ala Ser Phe Ala
    50                  55                  60                  
Gly Leu Gly Ala Pro Phe Glu Asp Ala Gly Ser Tyr Ser Val Asn Leu
65                  70                  75                  80  
Ser Leu Ala Pro Ala Gly Val Ile Arg Val Pro Ala His Arg Pro Leu
                85                  90                  95      
Pro Gly Ala Val Pro Pro Pro Leu Pro Ser Ala Leu Pro Ala Met Pro
            100                 105                 110         
Ser Val Pro Thr Val Ser Ser Leu Gly Gly Leu Asn Phe Pro Trp Met
        115                 120                 125             
Glu Ser Ser Arg Arg Phe Val Lys Asp Arg Phe Thr Ala Ala Ala Ala
    130                 135                 140                 
Leu Thr Pro Phe Thr Val Thr Arg Arg Ile Gly His Pro Tyr Gln Asn
145                 150                 155                 160 
Arg Thr Pro Pro Lys Arg Lys Lys Pro Arg Thr Ser Phe Ser Arg Val
                165                 170                 175     
Gln Ile Cys Glu Leu Glu Lys Arg Phe His Arg Gln Lys Tyr Leu Ala
            180                 185                 190         
Ser Ala Glu Arg Ala Ala Leu Ala Lys Ser Leu Lys Met Thr Asp Ala
        195                 200                 205             
Gln Val Lys Thr Trp Phe Gln Asn Arg Arg Thr Lys Trp Arg Arg Gln
    210                 215                 220                 
Thr Ala Glu Glu Arg Glu Ala Asp Gly Gln Gln Ala Ser Arg Leu Met
225                 230                 235                 240 
Leu Gln Leu Gln His Asp Ala Phe Gln Lys Ser Leu Asn Asp Ser Ile
                245                 250                 255     
Gln Pro Asp Pro Leu Cys Leu His Asn Ser Ser Leu Phe Ala Leu Gln
            260                 265                 270         
Asn Leu Gln Pro Trp Glu Glu Asp Ser Ser Lys Val Pro Ala Val Thr
        275                 280                 285             
Ser Leu Val
    290     


<210> 8033
<211> 551
<212> PRT
<213> Homo sapiens

<400> 8033
Met Lys Asp Ser Gly Asp Ser Lys Asp Gln Gln Leu Met Val Ala Leu
 1               5                  10                  15      
Arg Val Arg Pro Ile Ser Val Ala Glu Leu Glu Glu Gly Ala Thr Leu
            20                  25                  30          
Ile Ala His Lys Val Asp Glu Gln Met Val Val Leu Met Asp Pro Met
        35                  40                  45              
Glu Asp Pro Asp Asp Ile Leu Arg Ala His Arg Ser Arg Glu Lys Ser
    50                  55                  60                  
Tyr Leu Phe Asp Val Ala Phe Asp Phe Thr Ala Thr Gln Glu Met Val
65                  70                  75                  80  
Tyr Gln Ala Thr Thr Lys Ser Leu Ile Glu Gly Val Ile Ser Gly Tyr
                85                  90                  95      
Asn Ala Thr Val Phe Ala Tyr Gly Pro Thr Gly Cys Gly Lys Thr Tyr
            100                 105                 110         
Thr Met Leu Gly Thr Asp Gln Glu Pro Gly Ile Tyr Val Gln Thr Leu
        115                 120                 125             
Asn Asp Leu Phe Arg Ala Ile Glu Glu Thr Ser Asn Asp Met Glu Tyr
    130                 135                 140                 
Glu Val Ser Met Ser Tyr Leu Glu Ile Tyr Asn Glu Met Ile Arg Asp
145                 150                 155                 160 
Leu Leu Asn Pro Ser Leu Gly Tyr Leu Glu Leu Arg Glu Asp Ser Lys
                165                 170                 175     
Gly Val Ile Gln Val Ala Gly Ile Thr Glu Val Ser Thr Ile Asn Ala
            180                 185                 190         
Lys Glu Ala Ser Phe Ile Met Gln Leu Leu Met Lys Gly Asn Arg Gln
        195                 200                 205             
Arg Thr Gln Glu Pro Thr Ala Ala Asn Gln Thr Ser Ser Arg Ser His
    210                 215                 220                 
Ala Val Leu Gln Val Thr Val Arg Gln Arg Ser Arg Val Lys Asn Ile
225                 230                 235                 240 
Leu Gln Glu Val Arg Gln Gly Arg Leu Phe Met Ile Asp Leu Ala Gly
                245                 250                 255     
Ser Glu Arg Ala Ser Gln Thr Gln Asn Arg Gly Gln Arg Met Lys Glu
            260                 265                 270         
Gly Ala His Ile Asn Arg Ser Leu Leu Ala Leu Gly Asn Cys Ile Asn
        275                 280                 285             
Ala Leu Ser Asp Lys Gly Ser Asn Lys Tyr Ile Asn Tyr Arg Asp Ser
    290                 295                 300                 
Lys Leu Thr Arg Leu Leu Lys Asp Ser Leu Gly Gly Asn Ser Arg Thr
305                 310                 315                 320 
Val Met Ile Ala His Ile Ser Pro Ala Ser Ser Ala Phe Glu Glu Ser
                325                 330                 335     
Arg Asn Thr Leu Thr Tyr Ala Gly Arg Ala Lys Asn Ile Lys Thr Arg
            340                 345                 350         
Val Lys Gln Asn Leu Leu Asn Val Ser Tyr His Ile Ala Gln Tyr Thr
        355                 360                 365             
Ser Ile Ile Ala Asp Leu Arg Gly Glu Ile Gln Arg Leu Lys Arg Lys
    370                 375                 380                 
Ile Asp Glu Gln Thr Gly Arg Gly Gln Ala Arg Gly Arg Gln Asp Arg
385                 390                 395                 400 
Gly Asp Ile Arg His Ile Gln Ala Glu Val Gln Leu His Ser Gly Gln
                405                 410                 415     
Gly Glu Lys Ala Gly Met Gly Gln Leu Arg Glu Gln Leu Ala Ser Ala
            420                 425                 430         
Phe Gln Glu Gln Met Asp Val Arg Arg Arg Leu Leu Glu Leu Glu Asn
        435                 440                 445             
Arg Ala Met Glu Val Gln Ile Asp Thr Ser Arg His Leu Leu Thr Ile
    450                 455                 460                 
Ala Gly Trp Lys His Glu Lys Ser Arg Arg Ala Leu Lys Trp Arg Glu
465                 470                 475                 480 
Glu Gln Arg Lys Glu Cys Tyr Ala Lys Asp Asp Ser Glu Lys Asp Ser
                485                 490                 495     
Asp Thr Gly Asp Asp Gln Pro Asp Ile Leu Glu Pro Pro Glu Val Ala
            500                 505                 510         
Ala Ala Arg Glu Ser Ile Ala Ala Leu Val Asp Glu Gln Lys Gln Leu
        515                 520                 525             
Arg Lys Gln Lys Val Ser Arg Val Trp Gly Asp Lys Glu Ser Gly Phe
    530                 535                 540                 
Arg Gly Gln Gly Glu Gln Val
545                 550     


<210> 8034
<211> 538
<212> PRT
<213> Homo sapiens

<400> 8034
Met Ser Ser Pro Leu Ala Ser Glu Leu Ser Glu Leu Ala Ala Leu Arg
 1               5                  10                  15      
Pro Gly Phe Arg Leu Ser Ala Pro His Ala Arg Val Ala Pro Arg Ala
            20                  25                  30          
Ala Thr His Ala Arg Gly Arg Gly Arg Ala Ser His Ala Gly Gln Pro
        35                  40                  45              
Arg Leu Arg Ser Ser Cys Pro Gly Pro Ser Pro Gly Lys Arg Arg Val
    50                  55                  60                  
Val Pro Ser Gly Gly Ala Gln Pro Arg Val Leu Pro Ala Leu Ser Ser
65                  70                  75                  80  
Arg Ser His Leu Phe Pro Met Ala Ser His Pro Gln Thr Arg Ile Gln
                85                  90                  95      
Ala Tyr Leu Glu Lys Asn Lys Ile Gly Pro Leu Phe Glu Glu Leu Met
            100                 105                 110         
Thr Lys Leu Ile Thr Glu Thr Pro Asp Gln Pro Ile Pro Phe Leu Ile
        115                 120                 125             
Asp His Leu Gln Ser Lys Gln Gly Asn Arg Gly Gln Leu Gln Arg Thr
    130                 135                 140                 
Leu Ser Gly Ser Ala Ala Leu Trp Ala Glu Ser Glu Lys Ser Glu Ser
145                 150                 155                 160 
Lys Gly Thr Arg Arg Asp Phe Arg Ser Tyr Asp Lys Pro Trp Gln Leu
                165                 170                 175     
Asn Ala Lys Lys Pro Lys Lys Ser Lys Ser Asp Leu Ala Val Ser Asn
            180                 185                 190         
Ile Ser Pro Pro Ser Pro Asp Ser Lys Ser Leu Pro Arg Ser Val Glu
        195                 200                 205             
His Pro Lys Trp Asn Trp Arg Thr Lys Pro Gln Ser Arg Asp Phe Asp
    210                 215                 220                 
Glu Leu Asn His Ile Leu Gln Glu Ser Lys Lys Leu Gly Lys Ala Leu
225                 230                 235                 240 
Glu Asn Leu Ser Arg Ser Ile Ala Ile Ser Asp Glu Leu Asp Lys Glu
                245                 250                 255     
Thr Val Thr Phe Asn Ser Ser Leu Leu Arg Pro Arg Val Ile Gly Glu
            260                 265                 270         
Trp Ile Gly Arg Glu Glu Asn Asp Ala Asp Pro Leu Ala Ala Glu Met
        275                 280                 285             
Leu Gln Pro Pro Ile Pro Arg Ser Lys Asn Asp Gln Trp Glu Ser Glu
    290                 295                 300                 
Asp Ser Gly Ser Ser Pro Ala Gly Ser Leu Lys Met Glu Pro Lys Asn
305                 310                 315                 320 
Lys Gly Leu Lys Gln Gln Gln Gln Gln His Lys Lys Leu Leu Ala Ala
                325                 330                 335     
Met Leu Ser Gln Asp Ser Phe Glu Ser Ile His Ser Pro Thr Pro Ser
            340                 345                 350         
Val Thr Glu Glu Asp Ile Asp Asn Glu Asp Asp Ala Met Glu Leu Leu
        355                 360                 365             
Glu Asp Leu Asn Asp Leu Arg Met Glu Gly Val Thr Thr Leu Val Pro
    370                 375                 380                 
Ser Gly Ser Lys Phe Asn Gln Gly Arg Pro Thr Tyr Pro Ala Glu Pro
385                 390                 395                 400 
Gln Ala Lys Val Thr Leu Asn Ile Cys Ser Arg Cys Ala Arg Leu Gln
                405                 410                 415     
Gly Asp Asn Leu Glu Glu Arg Thr Glu Glu Ser Leu Pro Ile Leu His
            420                 425                 430         
Ser Pro Asp Glu Lys Ile Pro Asp Ser Phe Asp Ser Leu Pro Gly Thr
        435                 440                 445             
Glu Glu Ala Leu Met Glu Glu Gly Asp Glu Phe Glu Lys Ala Ser Lys
    450                 455                 460                 
Leu Thr Gly Pro Gly Glu Ala Ser Ser Gly Val Gly His Ser Leu Lys
465                 470                 475                 480 
Asn Tyr Met Glu Glu Asp Glu Ser Leu Lys Gln Leu Gln Val Val His
                485                 490                 495     
Gln Pro Trp Ile Leu Pro Ser Asp Thr Glu Ser Glu Gly Val Glu Ala
            500                 505                 510         
Glu Gln Glu Lys Arg Ser Ala Asp Leu Leu Leu Cys Val Pro Cys Ser
        515                 520                 525             
Ser Cys Pro Thr Leu Val Tyr Ser Gly Leu
    530                 535             


<210> 8035
<211> 129
<212> PRT
<213> Homo sapiens

<400> 8035
Met Ala Ser His Pro Gln Thr Arg Ile Gln Ala Tyr Leu Glu Lys Asn
 1               5                  10                  15      
Lys Ile Gly Pro Leu Phe Glu Glu Leu Met Thr Lys Leu Ile Thr Glu
            20                  25                  30          
Thr Pro Asp Gln Pro Ile Pro Phe Leu Ile Asp His Leu Gln Ser Lys
        35                  40                  45              
Gln Gly Asn Arg Gly Gln Leu Gln Arg Thr Leu Ser Gly Ser Ala Ala
    50                  55                  60                  
Leu Trp Ala Glu Ser Glu Lys Ser Glu Ser Lys Gly Thr Arg Arg Asp
65                  70                  75                  80  
Phe Arg Ser Tyr Asp Lys Pro Trp Gln Leu Asn Ala Lys Lys Pro Lys
                85                  90                  95      
Lys Ser Lys Ser Asp Leu Ala Val Ser Asn Ile Ser Pro Pro Ser Pro
            100                 105                 110         
Asp Ser Lys Ser Cys Lys Glu Val Ser Tyr Ser Asn Ala Ile Gln Ser
        115                 120                 125             
Met
    


<210> 8036
<211> 427
<212> PRT
<213> Homo sapiens

<400> 8036
Met Thr Lys Leu Ile Thr Glu Thr Pro Asp Gln Pro Ile Pro Phe Leu
 1               5                  10                  15      
Ile Asp His Leu Gln Ser Lys Gln Gly Asn Arg Gly Gln Leu Gln Arg
            20                  25                  30          
Thr Leu Ser Gly Ser Ala Ala Leu Trp Ala Glu Ser Glu Lys Ser Glu
        35                  40                  45              
Ser Lys Gly Thr Arg Arg Asp Phe Arg Ser Tyr Asp Lys Pro Trp Gln
    50                  55                  60                  
Leu Asn Ala Lys Lys Pro Lys Lys Ser Lys Ser Asp Leu Ala Val Ser
65                  70                  75                  80  
Asn Ile Ser Pro Pro Ser Pro Asp Ser Lys Ser Leu Pro Arg Ser Val
                85                  90                  95      
Glu His Pro Lys Trp Asn Trp Arg Thr Lys Pro Gln Ser Arg Asp Phe
            100                 105                 110         
Asp Glu Leu Asn His Ile Leu Gln Glu Ser Lys Lys Leu Gly Lys Ala
        115                 120                 125             
Leu Glu Asn Leu Ser Arg Ser Ile Ala Ile Ser Asp Glu Leu Asp Lys
    130                 135                 140                 
Glu Thr Val Thr Phe Asn Ser Ser Leu Leu Arg Pro Arg Val Ile Gly
145                 150                 155                 160 
Glu Trp Ile Gly Arg Glu Glu Asn Asp Ala Asp Pro Leu Ala Ala Glu
                165                 170                 175     
Met Leu Gln Pro Pro Ile Pro Arg Ser Lys Asn Asp Gln Trp Glu Ser
            180                 185                 190         
Glu Asp Ser Gly Ser Ser Pro Ala Gly Ser Leu Lys Met Glu Pro Lys
        195                 200                 205             
Asn Lys Gly Leu Lys Gln Gln Gln Gln Gln His Lys Lys Leu Leu Ala
    210                 215                 220                 
Ala Met Leu Ser Gln Asp Ser Phe Glu Ser Ile His Ser Pro Thr Pro
225                 230                 235                 240 
Ser Val Thr Glu Glu Asp Ile Asp Asn Glu Asp Asp Ala Met Glu Leu
                245                 250                 255     
Leu Glu Asp Leu Asn Asp Leu Arg Met Glu Gly Val Thr Thr Leu Val
            260                 265                 270         
Pro Ser Gly Ser Lys Phe Asn Gln Gly Arg Pro Thr Tyr Pro Ala Glu
        275                 280                 285             
Pro Gln Ala Lys Val Thr Leu Asn Ile Cys Ser Arg Cys Ala Arg Leu
    290                 295                 300                 
Gln Gly Asp Asn Leu Glu Glu Arg Thr Glu Glu Ser Leu Pro Ile Leu
305                 310                 315                 320 
His Ser Pro Asp Glu Lys Ile Pro Asp Ser Phe Asp Ser Leu Pro Gly
                325                 330                 335     
Thr Glu Glu Ala Leu Met Glu Glu Gly Asp Glu Phe Glu Lys Ala Ser
            340                 345                 350         
Lys Leu Thr Gly Pro Gly Glu Ala Ser Ser Gly Val Gly His Ser Leu
        355                 360                 365             
Lys Asn Tyr Met Glu Glu Asp Glu Ser Leu Lys Gln Leu Gln Val Val
    370                 375                 380                 
His Gln Pro Trp Ile Leu Pro Ser Asp Thr Glu Ser Glu Gly Val Glu
385                 390                 395                 400 
Ala Glu Gln Glu Lys Arg Ser Ala Asp Leu Leu Leu Cys Val Pro Cys
                405                 410                 415     
Ser Ser Cys Pro Thr Leu Val Tyr Ser Gly Leu
            420                 425         


<210> 8037
<211> 401
<212> PRT
<213> Homo sapiens

<400> 8037
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu
 1               5                  10                  15      
Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr
            20                  25                  30          
Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe
        35                  40                  45              
Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val
    50                  55                  60                  
Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe
65                  70                  75                  80  
Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile
                85                  90                  95      
Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe
            100                 105                 110         
Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr
        115                 120                 125             
Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser
    130                 135                 140                 
Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu
145                 150                 155                 160 
Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu Lys Phe Tyr Tyr
                165                 170                 175     
Asn Pro Asn Phe Lys Arg Gly Tyr Pro Gln Leu Leu Val Arg Val Lys
            180                 185                 190         
Arg Arg Ile Gly Val Lys Asn Ala Ser Pro Ile Ser Thr Leu Phe Asn
        195                 200                 205             
Glu Asp Phe Asn Lys Lys His Phe Arg Ala Gly Ala Asn Met Glu Asn
    210                 215                 220                 
His Asn Ser Ala Leu Ala Ala Glu Ala Ser Glu Glu Ser Leu Phe Ser
225                 230                 235                 240 
Ala Ser Lys Asn Leu Asn Met Pro Leu Thr Arg Glu Ser Ser Val Arg
                245                 250                 255     
Gln Ile Ile Ala Asn Ser Ser Val Pro Ile Arg Ser Gly Phe Pro Pro
            260                 265                 270         
Pro Ser Pro Ser Thr Ser Val Gly Pro Ser Glu Gln Ile Ala Thr Asp
        275                 280                 285             
Gln His Ala Ile Leu Asn Gln Leu Thr Thr Ile His Met His Ser His
    290                 295                 300                 
Ser Thr Tyr Met Gln Ala Arg Gly His Ile Val Asn Phe Ile Thr Thr
305                 310                 315                 320 
Thr Thr Ser Gln Tyr His Ile Ile Ser Pro Leu Gln Asn Gly Tyr Phe
                325                 330                 335     
Gly Leu Thr Val Glu Pro Ser Ala Val Pro Thr Arg Tyr Pro Leu Val
            340                 345                 350         
Ser Val Asn Glu Ala Pro Tyr Arg Asn Met Leu Pro Ala Gly Asn Pro
        355                 360                 365             
Trp Leu Gln Met Pro Thr Ile Ala Asp Arg Ser Ala Ala Pro His Ser
    370                 375                 380                 
Arg Leu Ala Leu Gln Pro Ser Pro Leu Asp Lys Tyr His Pro Asn Tyr
385                 390                 395                 400 
Asn
    


<210> 8038
<211> 203
<212> PRT
<213> Homo sapiens

<400> 8038
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu
 1               5                  10                  15      
Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr
            20                  25                  30          
Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe
        35                  40                  45              
Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val
    50                  55                  60                  
Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe
65                  70                  75                  80  
Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile
                85                  90                  95      
Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe
            100                 105                 110         
Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr
        115                 120                 125             
Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser
    130                 135                 140                 
Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu
145                 150                 155                 160 
Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Ile Arg Phe Thr Lys
                165                 170                 175     
Met Lys Leu Ser Arg Ser Ser Thr Tyr Glu Asn Arg Tyr Leu Cys Cys
            180                 185                 190         
Asn Leu His Leu Lys Asp Glu Ser Asn Tyr Ser
        195                 200             


<210> 8039
<211> 214
<212> PRT
<213> Homo sapiens

<400> 8039
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu
 1               5                  10                  15      
Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr
            20                  25                  30          
Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe
        35                  40                  45              
Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val
    50                  55                  60                  
Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe
65                  70                  75                  80  
Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile
                85                  90                  95      
Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe
            100                 105                 110         
Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr
        115                 120                 125             
Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser
    130                 135                 140                 
Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu
145                 150                 155                 160 
Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu His Val Phe Val
                165                 170                 175     
Phe His His Ser Leu Phe Gly Ala Thr Phe Gly Glu His His Phe Gln
            180                 185                 190         
Pro Cys Pro Leu Pro Ser Gly Asn Lys Ala Pro Ile Ser Thr Trp Ser
        195                 200                 205             
Gly Asp Ser Trp Leu Leu
    210                 


<210> 8040
<211> 1616
<212> PRT
<213> Homo sapiens

<400> 8040
Met Phe Pro Leu Ile Gly Lys Thr Ile Ile Phe Asp Asn Phe Pro Asp
 1               5                  10                  15      
Pro Ser Asp Thr Trp Glu Ile Thr Glu Thr Ile Gly Lys Gly Thr Tyr
            20                  25                  30          
Gly Lys Val Phe Lys Val Leu Asn Lys Lys Asn Gly Gln Lys Ala Ala
        35                  40                  45              
Val Lys Ile Leu Asp Pro Ile His Asp Ile Asp Glu Glu Ile Glu Ala
    50                  55                  60                  
Glu Tyr Asn Ile Leu Lys Ala Leu Ser Asp His Pro Asn Val Val Arg
65                  70                  75                  80  
Phe Tyr Gly Ile Tyr Phe Lys Lys Asp Lys Val Asn Gly Asp Lys Leu
                85                  90                  95      
Trp Leu Val Leu Glu Leu Cys Ser Gly Gly Ser Val Thr Asp Leu Val
            100                 105                 110         
Lys Gly Phe Leu Lys Arg Gly Glu Arg Met Ser Glu Pro Leu Ile Ala
        115                 120                 125             
Tyr Ile Leu His Glu Ala Leu Met Gly Leu Gln His Leu His Asn Asn
    130                 135                 140                 
Lys Thr Ile His Arg Asp Val Lys Gly Asn Asn Ile Leu Leu Thr Thr
145                 150                 155                 160 
Glu Gly Gly Val Lys Leu Val Asp Phe Gly Val Ser Ala Gln Leu Thr
                165                 170                 175     
Ser Thr Arg His Arg Arg Asn Thr Ser Val Gly Thr Pro Phe Trp Met
            180                 185                 190         
Ala Pro Glu Val Ile Ala Cys Glu Gln Gln Leu Asp Thr Thr Tyr Asp
        195                 200                 205             
Ala Arg Cys Asp Thr Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu Gly
    210                 215                 220                 
Asp Gly Asp Pro Pro Leu Ala Asp Leu His Pro Met Arg Ala Leu Phe
225                 230                 235                 240 
Lys Ile Pro Arg Asn Pro Pro Pro Lys Leu Arg Gln Pro Glu Leu Trp
                245                 250                 255     
Ser Ala Glu Phe Asn Asp Phe Ile Ser Lys Cys Leu Thr Lys Asp Tyr
            260                 265                 270         
Glu Lys Arg Pro Thr Val Ser Glu Leu Leu Gln His Lys Phe Ile Thr
        275                 280                 285             
Gln Ile Glu Gly Lys Asp Val Met Leu Gln Lys Gln Leu Thr Glu Phe
    290                 295                 300                 
Ile Gly Ile His Gln Cys Met Gly Gly Thr Glu Lys Ala Arg Arg Glu
305                 310                 315                 320 
Arg Ile His Thr Lys Lys Gly Asn Phe Asn Arg Pro Leu Ile Ser Asn
                325                 330                 335     
Leu Lys Asp Val Asp Asp Leu Ala Thr Leu Glu Ile Leu Asp Glu Asn
            340                 345                 350         
Thr Val Ser Glu Gln Leu Glu Lys Cys Tyr Ser Arg Asp Gln Ile Tyr
        355                 360                 365             
Val Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn Pro Phe Gln Ser Leu
    370                 375                 380                 
Gly Leu Tyr Ser Thr Lys His Ser Lys Leu Tyr Ile Gly Ser Lys Arg
385                 390                 395                 400 
Thr Ala Ser Pro Pro His Ile Phe Ala Met Ala Asp Leu Gly Tyr Gln
                405                 410                 415     
Ser Ile Ile Thr Tyr Asn Ser Asp Gln Cys Ile Val Ile Ser Gly Glu
            420                 425                 430         
Ser Gly Ala Gly Lys Thr Glu Asn Ala His Leu Leu Val Gln Gln Leu
        435                 440                 445             
Thr Val Leu Gly Lys Ala Asn Asn Arg Thr Leu Gln Glu Lys Ile Leu
    450                 455                 460                 
Gln Val Asn Asn Leu Val Glu Ala Phe Gly Asn Ala Cys Thr Ile Ile
465                 470                 475                 480 
Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu Glu Met Lys Phe Thr
                485                 490                 495     
Ser Ser Gly Ala Val Val Gly Ala Gln Ile Ser Glu Tyr Leu Leu Glu
            500                 505                 510         
Lys Ser Arg Val Ile His Gln Ala Ile Gly Glu Lys Asn Phe His Ile
        515                 520                 525             
Phe Tyr Tyr Ile Tyr Ala Gly Leu Ala Glu Lys Lys Lys Leu Ala His
    530                 535                 540                 
Tyr Lys Leu Pro Glu Asn Lys Pro Pro Arg Tyr Leu Gln Asn Asp His
545                 550                 555                 560 
Leu Arg Thr Val Gln Asp Ile Met Asn Asn Ser Phe Tyr Lys Ser Gln
                565                 570                 575     
Tyr Glu Leu Ile Glu Gln Cys Phe Lys Val Ile Gly Phe Thr Met Glu
            580                 585                 590         
Gln Leu Gly Ser Ile Tyr Ser Ile Leu Ala Ala Ile Leu Asn Val Gly
        595                 600                 605             
Asn Ile Glu Phe Ser Ser Val Ala Thr Glu His Gln Ile Asp Lys Ser
    610                 615                 620                 
His Ile Ser Asn His Thr Ala Leu Glu Asn Cys Val Ser Leu Leu Cys
625                 630                 635                 640 
Ile Arg Ala Asp Glu Leu Gln Glu Ala Leu Thr Ser His Cys Val Val
                645                 650                 655     
Thr Arg Gly Glu Thr Ile Ile Arg Pro Asn Thr Val Glu Lys Ala Thr
            660                 665                 670         
Asp Val Arg Asp Ala Met Ala Lys Thr Leu Tyr Gly Arg Leu Phe Ser
        675                 680                 685             
Trp Ile Val Asn Cys Ile Asn Ser Leu Leu Lys His Asp Ser Ser Pro
    690                 695                 700                 
Ser Gly Asn Gly Asp Glu Leu Ser Ile Gly Ile Leu Asp Ile Phe Gly
705                 710                 715                 720 
Phe Glu Asn Phe Lys Lys Asn Ser Phe Glu Gln Leu Cys Ile Asn Ile
                725                 730                 735     
Ala Asn Glu Gln Ile Gln Tyr Tyr Tyr Asn Gln His Val Phe Ala Trp
            740                 745                 750         
Glu Gln Asn Glu Tyr Leu Asn Glu Asp Val Asp Ala Arg Val Ile Glu
        755                 760                 765             
Tyr Glu Asp Asn Trp Pro Leu Leu Asp Met Phe Leu Gln Lys Pro Met
    770                 775                 780                 
Gly Leu Leu Ser Leu Leu Asp Glu Glu Ser Arg Phe Pro Lys Ala Thr
785                 790                 795                 800 
Asp Gln Thr Leu Val Glu Lys Phe Glu Gly Asn Leu Lys Ser Gln Tyr
                805                 810                 815     
Phe Trp Arg Pro Lys Arg Met Glu Leu Ser Phe Gly Ile His His Tyr
            820                 825                 830         
Ala Gly Lys Val Leu Tyr Asn Ala Ser Gly Phe Leu Ala Lys Asn Arg
        835                 840                 845             
Asp Thr Leu Pro Thr Asp Ile Val Leu Leu Leu Arg Ser Ser Asp Asn
    850                 855                 860                 
Ser Val Ile Arg Gln Leu Val Asn His Pro Leu Thr Lys Thr Gly Asn
865                 870                 875                 880 
Leu Pro His Ser Lys Thr Lys Asn Val Ile Asn Tyr Gln Met Arg Thr
                885                 890                 895     
Ser Glu Lys Leu Ile Asn Leu Ala Lys Gly Asp Thr Gly Glu Ala Thr
            900                 905                 910         
Arg His Ala Arg Glu Thr Thr Asn Met Lys Thr Gln Thr Val Ala Ser
        915                 920                 925             
Tyr Phe Arg Tyr Ser Leu Met Asp Leu Leu Ser Lys Met Val Val Gly
    930                 935                 940                 
Gln Pro His Phe Val Arg Cys Ile Lys Pro Asn Ser Glu Arg Gln Ala
945                 950                 955                 960 
Arg Lys Tyr Asp Lys Glu Lys Val Leu Leu Gln Leu Arg Tyr Thr Gly
                965                 970                 975     
Ile Leu Glu Thr Ala Arg Ile Arg Arg Leu Gly Phe Ser His Arg Ile
            980                 985                 990         
Leu Phe Ala Asn Phe Ile Lys Arg Tyr Tyr Leu Leu Cys Tyr Lys Ser
        995                 1000                1005            
Ser Glu Glu Pro Arg Met Ser Pro Asp Thr Cys Ala Thr Ile Leu Glu
    1010                1015                1020                
Lys Ala Gly Leu Asp Asn Trp Ala Leu Gly Lys Thr Lys Val Phe Leu
1025                1030                1035                1040
Lys Tyr Tyr His Val Glu Gln Leu Asn Leu Met Arg Lys Glu Ala Ile
                1045                1050                1055    
Asp Lys Leu Ile Leu Ile Gln Ala Cys Val Arg Ala Phe Leu Cys Ser
            1060                1065                1070        
Arg Arg Tyr Gln Lys Ile Gln Glu Lys Arg Lys Glu Ser Ala Ile Ile
        1075                1080                1085            
Ile Gln Ser Ala Ala Arg Gly His Leu Val Gly Lys Gln Arg Lys Glu
    1090                1095                1100                
Ile Val Asp Met Lys Asn Thr Ala Val Thr Thr Ile Gln Thr Ser Asp
1105                1110                1115                1120
Gln Glu Phe Asp Tyr Lys Lys Asn Phe Glu Asn Thr Arg Glu Ser Phe
                1125                1130                1135    
Val Lys Lys Gln Ala Glu Asn Ala Ile Ser Ala Asn Glu Arg Phe Ile
            1140                1145                1150        
Ser Ala Pro Asn Asn Lys Gly Ser Val Ser Val Val Lys Thr Ser Thr
        1155                1160                1165            
Phe Lys Pro Glu Glu Glu Thr Thr Asn Ala Val Glu Ser Asn Asn Arg
    1170                1175                1180                
Val Tyr Gln Thr Pro Lys Lys Met Asn Asn Val Tyr Glu Glu Glu Val
1185                1190                1195                1200
Lys Gln Glu Phe Tyr Leu Val Gly Pro Glu Val Ser Pro Lys Gln Lys
                1205                1210                1215    
Phe Val Lys Asp Leu Glu Glu Asn Ser Asn Leu Arg Lys Val Glu Lys
            1220                1225                1230        
Glu Glu Ala Met Ile Gln Ser Tyr Tyr Gln Arg Tyr Thr Glu Glu Arg
        1235                1240                1245            
Asn Cys Glu Glu Ser Lys Ala Ala Tyr Leu Glu Arg Lys Ala Ile Ser
    1250                1255                1260                
Glu Arg Pro Ser Tyr Pro Val Pro Trp Leu Ala Glu Asn Glu Thr Ser
1265                1270                1275                1280
Phe Lys Lys Thr Leu Glu Pro Thr Leu Ser Gln Arg Ser Ile Tyr Gln
                1285                1290                1295    
Asn Ala Asn Ser Met Glu Lys Glu Lys Lys Thr Ser Val Val Thr Gln
            1300                1305                1310        
Ser Ala Pro Ile Cys Ser Gln Glu Glu Gly Arg Gly Arg Leu Arg His
        1315                1320                1325            
Glu Thr Val Lys Glu Arg Gln Val Glu Pro Val Thr Gln Ala Gln Glu
    1330                1335                1340                
Glu Glu Asp Lys Ala Ala Val Phe Ile Gln Ser Lys Tyr Arg Gly Tyr
1345                1350                1355                1360
Lys Arg Arg Gln Gln Leu Arg Lys Asp Lys Met Ser Ser Phe Lys His
                1365                1370                1375    
Gln Lys Ile Val Thr Thr Pro Thr Glu Val Ala Arg Asn Thr His Asn
            1380                1385                1390        
Leu Tyr Ser Tyr Pro Thr Lys His Glu Glu Ile Asn Asn Ile Lys Lys
        1395                1400                1405            
Lys Asp Asn Lys Asp Ser Lys Ala Thr Ser Glu Arg Glu Ala Cys Gly
    1410                1415                1420                
Leu Ala Ile Phe Ser Lys Gln Ile Ser Lys Leu Ser Glu Glu Tyr Phe
1425                1430                1435                1440
Ile Leu Gln Lys Lys Leu Asn Glu Met Ile Leu Ser Gln Gln Leu Lys
                1445                1450                1455    
Ser Leu Tyr Leu Gly Val Ser His His Lys Pro Ile Asn Arg Arg Val
            1460                1465                1470        
Ser Ser Gln Gln Cys Leu Ser Gly Val Cys Lys Gly Glu Glu Pro Lys
        1475                1480                1485            
Ile Leu Arg Pro Pro Arg Arg Pro Arg Lys Pro Lys Thr Leu Asn Asn
    1490                1495                1500                
Pro Glu Asp Ser Thr Tyr Tyr Tyr Leu Leu His Lys Ser Ile Gln Glu
1505                1510                1515                1520
Glu Lys Arg Arg Pro Arg Lys Asp Ser Gln Gly Lys Leu Leu Asp Leu
                1525                1530                1535    
Glu Asp Phe Tyr Tyr Lys Glu Phe Leu Pro Ser Arg Ser Gly Pro Lys
            1540                1545                1550        
Glu His Ser Pro Ser Leu Arg Glu Arg Arg Pro Gln Gln Glu Leu Gln
        1555                1560                1565            
Asn Gln Cys Ile Lys Ala Asn Glu Arg Cys Trp Ala Ala Glu Ser Pro
    1570                1575                1580                
Glu Lys Glu Glu Glu Arg Glu Pro Ala Ala Asn Pro Tyr Asp Phe Arg
1585                1590                1595                1600
Arg Leu Leu Arg Lys Thr Ser Gln Arg Arg Arg Leu Val Gln Gln Ser
                1605                1610                1615    


<210> 8041
<211> 837
<212> PRT
<213> Homo sapiens

<400> 8041
Met Asn His Leu Glu Gly Ser Ala Glu Val Glu Val Thr Asp Glu Ala
 1               5                  10                  15      
Ala Gly Gly Glu Val Asn Glu Ser Val Glu Ala Asp Leu Glu His Pro
            20                  25                  30          
Glu Val Glu Glu Glu Gln Gln Gln Pro Pro Gln Gln Gln His Tyr Val
        35                  40                  45              
Gly Arg His Gln Arg Gly Arg Ala Leu Glu Asp Leu Arg Ala Gln Leu
    50                  55                  60                  
Gly Gln Glu Glu Glu Glu Arg Gly Glu Cys Leu Ala Arg Ser Ala Ser
65                  70                  75                  80  
Thr Glu Ser Gly Phe His Asn His Thr Asp Thr Ala Glu Gly Asp Val
                85                  90                  95      
Ile Ala Ala Ala Arg Asp Gly Tyr Asp Ala Glu Arg Ala Gln Asp Pro
            100                 105                 110         
Glu Asp Glu Ser Ala Tyr Ala Val Gln Tyr Arg Pro Glu Ala Glu Glu
        115                 120                 125             
Tyr Thr Glu Gln Ala Glu Ala Glu His Ala Glu Ala Thr His Arg Arg
    130                 135                 140                 
Ala Leu Pro Asn His Leu His Phe His Ser Leu Glu His Glu Glu Ala
145                 150                 155                 160 
Met Asn Ala Ala Tyr Ser Gly Tyr Val Tyr Thr His Arg Leu Phe His
                165                 170                 175     
Arg Gly Glu Asp Glu Pro Tyr Ser Glu Pro Tyr Ala Asp Tyr Gly Gly
            180                 185                 190         
Leu Gln Glu His Val Tyr Glu Glu Ile Gly Asp Ala Pro Glu Leu Asp
        195                 200                 205             
Ala Arg Asp Gly Leu Arg Leu Tyr Glu Gln Glu Arg Asp Glu Ala Ala
    210                 215                 220                 
Ala Tyr Arg Gln Glu Ala Leu Gly Ala Arg Leu His His Tyr Asp Glu
225                 230                 235                 240 
Arg Ser Asp Gly Glu Ser Asp Ser Pro Glu Lys Glu Ala Glu Phe Ala
                245                 250                 255     
Pro Tyr Pro Arg Met Asp Ser Tyr Glu Gln Glu Glu Asp Ile Asp Gln
            260                 265                 270         
Ile Val Ala Glu Val Lys Gln Ser Met Ser Ser Gln Ser Leu Asp Lys
        275                 280                 285             
Ala Ala Glu Asp Met Pro Glu Ala Glu Gln Asp Leu Glu Arg Pro Pro
    290                 295                 300                 
Thr Pro Ala Gly Gly Arg Pro Asp Ser Pro Gly Leu Gln Ala Pro Ala
305                 310                 315                 320 
Gly Gln Gln Arg Ala Val Gly Pro Ala Gly Gly Gly Glu Ala Gly Gln
                325                 330                 335     
Arg Tyr Ser Lys Glu Lys Arg Asp Ala Ile Ser Leu Ala Ile Lys Asp
            340                 345                 350         
Ile Lys Glu Ala Ile Glu Glu Val Lys Thr Arg Thr Ile Arg Ser Pro
        355                 360                 365             
Tyr Thr Pro Asp Glu Pro Lys Glu Pro Ile Trp Val Met Arg Gln Asp
    370                 375                 380                 
Ile Ser Pro Thr Arg Asp Cys Asp Asp Gln Arg Pro Met Asp Gly Asp
385                 390                 395                 400 
Ser Pro Ser Pro Gly Ser Ser Ser Pro Leu Gly Ala Glu Ser Ser Ser
                405                 410                 415     
Thr Ser Leu His Pro Ser Asp Pro Val Glu Val Pro Ile Asn Lys Glu
            420                 425                 430         
Ser Arg Lys Ser Leu Ala Ser Phe Pro Thr Tyr Val Glu Val Pro Gly
        435                 440                 445             
Pro Cys Asp Pro Glu Asp Leu Ile Asp Gly Ile Ile Phe Ala Ala Asn
    450                 455                 460                 
Tyr Leu Gly Ser Thr Gln Leu Leu Ser Asp Lys Thr Pro Ser Lys Asn
465                 470                 475                 480 
Val Arg Met Met Gln Ala Gln Glu Ala Val Ser Arg Ile Lys Met Ala
                485                 490                 495     
Gln Lys Leu Ala Lys Ser Arg Lys Lys Ala Pro Glu Gly Glu Ser Gln
            500                 505                 510         
Pro Met Thr Glu Val Asp Leu Phe Ile Leu Thr Gln Arg Ile Lys Val
        515                 520                 525             
Leu Asn Ala Asp Thr Gln Glu Thr Met Met Asp His Pro Leu Arg Thr
    530                 535                 540                 
Ile Ser Tyr Ile Ala Asp Ile Gly Asn Ile Val Val Leu Met Ala Arg
545                 550                 555                 560 
Arg Arg Ile Pro Arg Ser Asn Ser Gln Glu Asn Val Glu Ala Ser His
                565                 570                 575     
Pro Ser Gln Asp Gly Lys Arg Gln Tyr Lys Met Ile Cys His Val Phe
            580                 585                 590         
Glu Ser Glu Asp Ala Gln Leu Ile Ala Gln Ser Ile Gly Gln Ala Phe
        595                 600                 605             
Ser Val Ala Tyr Gln Glu Phe Leu Arg Ala Asn Gly Ile Asn Pro Glu
    610                 615                 620                 
Asp Leu Ser Gln Lys Glu Tyr Ser Asp Leu Leu Asn Thr Gln Asp Met
625                 630                 635                 640 
Tyr Asn Asp Asp Leu Ile His Phe Ser Lys Ser Glu Asn Cys Lys Asp
                645                 650                 655     
Val Phe Ile Glu Lys Gln Lys Gly Glu Ile Leu Gly Val Val Ile Val
            660                 665                 670         
Glu Ser Gly Trp Gly Ser Ile Leu Pro Thr Val Ile Ile Ala Asn Met
        675                 680                 685             
Met His Gly Gly Pro Ala Glu Lys Ser Gly Lys Leu Asn Ile Gly Asp
    690                 695                 700                 
Gln Ile Met Ser Ile Asn Gly Thr Ser Leu Val Gly Leu Pro Leu Ser
705                 710                 715                 720 
Thr Cys Gln Ser Ile Ile Lys Gly Leu Glu Asn Gln Ser Arg Val Lys
                725                 730                 735     
Leu Asn Ile Val Arg Cys Pro Pro Val Thr Thr Val Leu Ile Arg Arg
            740                 745                 750         
Pro Asp Leu Arg Tyr Gln Leu Gly Phe Ser Val Gln Asn Gly Ile Ile
        755                 760                 765             
Cys Ser Leu Met Arg Gly Gly Ile Ala Glu Arg Gly Gly Val Arg Val
    770                 775                 780                 
Gly His Arg Ile Ile Glu Ile Asn Gly Gln Ser Val Val Ala Thr Pro
785                 790                 795                 800 
His Glu Lys Ile Val His Ile Leu Ser Asn Ala Val Gly Glu Ile His
                805                 810                 815     
Met Lys Thr Met Pro Ala Ala Met Tyr Arg Leu Leu Thr Ala Gln Glu
            820                 825                 830         
Gln Pro Val Tyr Ile
        835         


<210> 8042
<211> 553
<212> PRT
<213> Homo sapiens

<400> 8042
Met Thr Ser Ala Met Ala Arg Gly Ala Tyr Gly Arg Pro Gly Ser Asp
 1               5                  10                  15      
Phe Cys His Gly Thr Glu Gly Lys Asp Leu Pro Ser Glu His Asn Val
            20                  25                  30          
Ser Val Glu Gly Val Ala Gln Asp Arg Ser Pro Glu Ala Thr Leu Cys
        35                  40                  45              
Pro Gln Lys Thr Cys Pro Cys Asp Ile Cys Gly Leu Arg Leu Lys Asp
    50                  55                  60                  
Ile Leu His Leu Ala Glu His Gln Thr Thr His Pro Arg Gln Lys Pro
65                  70                  75                  80  
Phe Val Cys Glu Ala Tyr Val Lys Gly Ser Glu Phe Ser Ala Asn Leu
                85                  90                  95      
Pro Gln Lys Gln Val Gln Gln Asn Val His Asn Pro Ile Arg Thr Glu
            100                 105                 110         
Glu Gly Gln Ala Ser Pro Val Lys Thr Cys Arg Asp His Thr Ser Asp
        115                 120                 125             
Gln Leu Ser Thr Cys Arg Glu Gly Gly Lys Asp Phe Val Ala Thr Ala
    130                 135                 140                 
Gly Phe Leu Gln Cys Glu Val Thr Pro Ser Asp Gly Glu Pro His Glu
145                 150                 155                 160 
Ala Thr Glu Gly Val Val Asp Phe His Ile Ala Leu Arg His Asn Lys
                165                 170                 175     
Cys Cys Glu Ser Gly Asp Ala Phe Asn Asn Lys Ser Thr Leu Val Gln
            180                 185                 190         
His Gln Arg Ile His Ser Arg Glu Arg Pro Tyr Glu Cys Ser Lys Cys
        195                 200                 205             
Gly Ile Phe Phe Thr Tyr Ala Ala Asp Leu Thr Gln His Gln Lys Val
    210                 215                 220                 
His Asn Arg Gly Lys Pro Tyr Glu Cys Cys Glu Cys Gly Lys Phe Phe
225                 230                 235                 240 
Ser Gln His Ser Ser Leu Val Lys His Arg Arg Val His Thr Gly Glu
                245                 250                 255     
Ser Pro His Val Cys Gly Asp Cys Gly Lys Phe Phe Ser Arg Ser Ser
            260                 265                 270         
Asn Leu Ile Gln His Lys Arg Val His Thr Gly Glu Lys Pro Tyr Glu
        275                 280                 285             
Cys Ser Asp Cys Gly Lys Phe Phe Ser Gln Arg Ser Asn Leu Ile His
    290                 295                 300                 
His Lys Arg Val His Thr Gly Arg Ser Ala His Glu Cys Ser Glu Cys
305                 310                 315                 320 
Gly Lys Ser Phe Asn Cys Asn Ser Ser Leu Ile Lys His Trp Arg Val
                325                 330                 335     
His Thr Gly Glu Arg Pro Tyr Lys Cys Asn Glu Cys Gly Lys Phe Phe
            340                 345                 350         
Ser His Ile Ala Ser Leu Ile Gln His Gln Ile Val His Thr Gly Glu
        355                 360                 365             
Arg Pro His Gly Cys Gly Glu Cys Gly Lys Ala Phe Ser Arg Ser Ser
    370                 375                 380                 
Asp Leu Met Lys His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Glu
385                 390                 395                 400 
Cys Asn Glu Cys Gly Lys Leu Phe Ser Gln Ser Ser Ser Leu Asn Ser
                405                 410                 415     
His Arg Arg Leu His Thr Gly Glu Arg Pro Tyr Gln Cys Ser Glu Cys
            420                 425                 430         
Gly Lys Phe Phe Asn Gln Ser Ser Ser Leu Asn Asn His Arg Arg Leu
        435                 440                 445             
His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Thr Phe
    450                 455                 460                 
Arg Gln Arg Ser Asn Leu Arg Gln His Leu Lys Val His Lys Pro Asp
465                 470                 475                 480 
Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Asn Gln Arg Pro
                485                 490                 495     
Thr Leu Ile Arg His Gln Lys Ile His Ile Arg Glu Arg Ser Met Glu
            500                 505                 510         
Asn Val Leu Leu Pro Cys Ser Gln His Thr Pro Glu Ile Ser Ser Glu
        515                 520                 525             
Asn Arg Pro Tyr Gln Gly Ala Val Asn Tyr Lys Leu Lys Leu Val His
    530                 535                 540                 
Pro Ser Thr His Pro Gly Glu Val Pro
545                 550             


<210> 8043
<211> 863
<212> PRT
<213> Homo sapiens

<400> 8043
Lys Ile Ile Ile Lys Tyr Ile Ser Leu Gly Ile Leu Phe Ser Leu Lys
 1               5                  10                  15      
Tyr Phe Leu Phe Phe Ser Asn Gln Gln Asp Ala Thr Ser Val Ala Thr
            20                  25                  30          
Glu Ser Ser Glu Ser Ser Thr Ser Asp Leu Pro Ser Phe Glu Val Gly
        35                  40                  45              
Ile Arg Ala Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu
    50                  55                  60                  
Glu Arg Asn Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Thr
65                  70                  75                  80  
Glu Asn Val Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro
                85                  90                  95      
Asn Leu Ser Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Thr
            100                 105                 110         
Glu Ser Glu Ser Lys Asn Ser His Ser Lys Thr Ser Val Glu Lys Asn
        115                 120                 125             
His Val Glu Lys Asp Lys Met Asn Thr Leu Asp Ile Leu Arg Met Glu
    130                 135                 140                 
Thr Thr Glu Arg Glu Asn Pro Glu Ala Glu Thr Val Ser Val Leu Gly
145                 150                 155                 160 
Glu Lys Asn Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro
                165                 170                 175     
Val Gln Val Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys
            180                 185                 190         
Ala Ala Glu Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala
        195                 200                 205             
Asn Val Glu Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Thr Pro
    210                 215                 220                 
Gln His Met Glu Asp Gln Ser Cys Lys Asp Phe Glu Glu Glu Asp Val
225                 230                 235                 240 
Ile Leu Gln Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp
                245                 250                 255     
Glu Pro Lys Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys
            260                 265                 270         
Ala Asn Lys Leu Asn Gln Val Pro Ile Leu Arg Thr Arg Phe Gln Lys
        275                 280                 285             
Pro Lys Pro Asn Ile Gly Arg Gly Thr Gly Arg Arg Glu Ile Ser Ser
    290                 295                 300                 
Lys Glu Glu Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala
305                 310                 315                 320 
Ala Leu Arg Glu Thr Val Arg Leu Asp Thr Ser Pro Lys Glu Met Val
                325                 330                 335     
Pro Ala Glu Ile Asn Thr Lys Glu Met Gln Ser Asp Leu Lys Glu Thr
            340                 345                 350         
Gly Arg Arg Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp
        355                 360                 365             
Asp Thr Ile Glu Met Glu Thr Gly Leu Lys Ala Met Gly Arg Glu Ile
    370                 375                 380                 
Cys Leu Arg Glu Lys Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile
385                 390                 395                 400 
Asp Lys Asp Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys
                405                 410                 415     
Asn Gly Pro Glu Glu Val Lys Pro Leu Gly Glu Val Glu Thr Asp Leu
            420                 425                 430         
Lys Ala Thr Gly Asn Glu Ser Ser Pro Arg Glu Lys Thr Pro Glu Val
        435                 440                 445             
Thr Asp Ala Thr Glu Glu Ile Asp Lys Asn Leu Glu Glu Thr Gly Arg
    450                 455                 460                 
Arg Lys Ile Ser Pro Arg Glu Asn Gly Pro Glu Glu Val Lys Pro Val
465                 470                 475                 480 
Asp Glu Met Glu Thr Asp Leu Asn Ala Thr Gly Arg Glu Ser Ser Pro
                485                 490                 495     
Arg Glu Lys Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile Asp Leu
            500                 505                 510         
Glu Glu Thr Glu Arg Glu Val Ser Pro Gln Glu Asn Gly Leu Glu Glu
        515                 520                 525             
Val Lys Pro Leu Gly Glu Met Glu Thr Asp Leu Lys Ala Thr Gly Arg
    530                 535                 540                 
Asp Ser Phe Pro Arg Gly Lys Thr Pro Glu Val Ile Asp Ala Ile Glu
545                 550                 555                 560 
Glu Ile Glu Ile Asp Leu Glu Glu Thr Glu Arg Glu Ile Ser Pro Gln
                565                 570                 575     
Glu Asn Gly Leu Glu Glu Val Lys Pro Leu Gly Glu Met Gln Thr Asp
            580                 585                 590         
Leu Lys Ala Thr Gly Arg Glu Ile Ser Pro Arg Glu Lys Thr Pro Glu
        595                 600                 605             
Val Ile Asp Ala Thr Glu Glu Ile Asp Lys Asp Leu Glu Glu Thr Gly
    610                 615                 620                 
Arg Arg Glu Ile Ser Pro Glu Glu Asn Gly Pro Glu Glu Val Lys Pro
625                 630                 635                 640 
Val Asp Glu Met Glu Thr Asp Leu Lys Thr Thr Gly Arg Glu Gly Ser
                645                 650                 655     
Ser Arg Glu Lys Thr Arg Glu Val Ile Asp Ala Ala Glu Val Ile Glu
            660                 665                 670         
Thr Asp Leu Glu Glu Thr Glu Arg Glu Ile Ser Pro Gln Glu Asn Gly
        675                 680                 685             
Pro Glu Glu Val Lys Pro Val Gly Lys Met Glu Thr Asp Leu Lys Glu
    690                 695                 700                 
Ile Arg Glu Glu Ile Ser Gln Arg Glu Lys Val Leu Ala Glu Phe Ser
705                 710                 715                 720 
Ala Ile Arg Glu Lys Glu Ile Asp Leu Lys Glu Thr Gly Lys Arg Asp
                725                 730                 735     
Ile Pro Met Met Glu Lys Val Ser Gly Lys Met Ala Val Val Glu Glu
            740                 745                 750         
Met Glu Ala Asp Leu Lys Glu Thr Gly Lys Glu Asn Phe Arg Glu Arg
        755                 760                 765             
Gly Ser Glu Glu Ile Cys Val Thr Glu Glu Lys Val Ala Glu Leu Lys
    770                 775                 780                 
Gln Thr Gly Lys Thr Asp Ile Ser Pro Arg Glu Asn Glu Leu Glu Glu
785                 790                 795                 800 
Thr Ser Thr Ser Arg Gln Thr Asp Thr His Leu Met Gln Ser Gly Ser
                805                 810                 815     
Asn Asp Phe Ser Ala Met Pro Ser Leu Asp Ile Gln Val Cys Ile Phe
            820                 825                 830         
Leu Ser Phe Lys Ser Phe Leu Asn Ala Phe Ser Glu Glu Ile Asn Asn
        835                 840                 845             
Ser Met Ile Ile Leu Ser Leu Ser Pro Thr Thr Phe Lys Asn Leu
    850                 855                 860             


<210> 8044
<211> 4486
<212> PRT
<213> Homo sapiens

<400> 8044
Met Arg Leu Ala Glu Glu Arg Ala Ala Leu Ala Ala Glu Asn Ala Asp
 1               5                  10                  15      
Gly Glu Pro Gly Ala Asp Arg Arg Leu Arg Leu Leu Gly Thr Tyr Val
            20                  25                  30          
Ala Met Ser Leu Arg Pro Ala Ala Gly Ala Trp Glu Arg Cys Ala Gly
        35                  40                  45              
Ser Ala Glu Ala Glu Gln Leu Leu Gln Ala Phe Leu Gly Arg Asp Ala
    50                  55                  60                  
Ala Glu Gly Pro Arg Pro Leu Leu Val Val Arg Pro Gly Pro Arg Gly
65                  70                  75                  80  
Leu Ala Ile Arg Pro Gly Leu Glu Val Gly Pro Glu Ser Gly Leu Ala
                85                  90                  95      
Gly Ala Lys Ala Leu Phe Phe Leu Arg Thr Gly Pro Glu Pro Pro Gly
            100                 105                 110         
Pro Asp Ser Phe Arg Gly Ala Val Val Cys Gly Asp Leu Pro Ala Ala
        115                 120                 125             
Pro Leu Glu His Leu Ala Ala Leu Phe Ser Glu Val Val Leu Pro Val
    130                 135                 140                 
Leu Ala Asn Glu Lys Asn Arg Leu Asn Trp Pro His Met Ile Cys Glu
145                 150                 155                 160 
Asp Val Arg Arg His Ala His Ser Leu Gln Cys Asp Leu Ser Val Ile
                165                 170                 175     
Leu Glu Gln Val Lys Gly Lys Thr Leu Leu Pro Leu Pro Ala Gly Ser
            180                 185                 190         
Glu Lys Met Glu Phe Ala Asp Ser Lys Ser Glu Thr Val Leu Asp Ser
        195                 200                 205             
Ile Asp Lys Ser Val Ile Tyr Ala Ile Glu Ser Ala Val Ile Lys Trp
    210                 215                 220                 
Ser Tyr Gln Val Gln Val Val Leu Lys Arg Glu Ser Ser Gln Pro Leu
225                 230                 235                 240 
Leu Gln Gly Glu Asn Pro Thr Pro Lys Val Glu Leu Glu Phe Trp Lys
                245                 250                 255     
Ser Arg Tyr Glu Asp Leu Lys Tyr Ile Tyr Asn Gln Leu Arg Thr Ile
            260                 265                 270         
Thr Val Arg Gly Met Ala Lys Leu Leu Asp Lys Leu Gln Ser Ser Tyr
        275                 280                 285             
Phe Pro Ala Phe Lys Ala Met Tyr Arg Asp Val Val Ala Ala Leu Ala
    290                 295                 300                 
Glu Ala Gln Asp Ile His Val His Leu Ile Pro Leu Gln Arg His Leu
305                 310                 315                 320 
Glu Ala Leu Glu Asn Ala Glu Phe Pro Glu Val Lys Pro Gln Leu Arg
                325                 330                 335     
Pro Leu Leu His Val Val Cys Leu Ile Trp Ala Thr Cys Lys Ser Tyr
            340                 345                 350         
Arg Ser Pro Gly Arg Leu Thr Val Leu Leu Gln Glu Ile Cys Asn Leu
        355                 360                 365             
Leu Ile Gln Gln Ala Ser Asn Tyr Leu Ser Pro Glu Asp Leu Leu Arg
    370                 375                 380                 
Ser Glu Val Glu Glu Ser Gln Arg Lys Leu Gln Val Val Ser Asp Thr
385                 390                 395                 400 
Leu Ser Phe Phe Lys Gln Glu Phe Gln Asp Arg Arg Glu Asn Leu His
                405                 410                 415     
Thr Tyr Phe Lys Glu Asn Gln Glu Val Lys Glu Trp Asp Phe Gln Ser
            420                 425                 430         
Ser Leu Val Phe Val Arg Leu Asp Gly Phe Leu Gly Arg Leu His Val
        435                 440                 445             
Val Glu Gly Leu Leu Lys Thr Ala Leu Asp Phe His Lys Leu Gly Lys
    450                 455                 460                 
Val Glu Phe Ser Gly Val Arg Gly Asn Ala Leu Ser Gln Gln Val Gln
465                 470                 475                 480 
Gln Met His Glu Glu Phe Gln Glu Met Tyr Arg Leu Leu Ser Gly Ser
                485                 490                 495     
Ser Ser Asp Cys Leu Tyr Leu Gln Ser Thr Asp Phe Glu Asn Asp Val
            500                 505                 510         
Ser Glu Phe Asn Gln Lys Val Glu Asp Leu Asp Arg Arg Leu Gly Thr
        515                 520                 525             
Ile Phe Ile Gln Ala Phe Asp Asp Ala Pro Gly Leu Glu His Ala Phe
    530                 535                 540                 
Lys Leu Leu Asp Ile Ala Gly Asn Leu Leu Glu Arg Pro Leu Val Ala
545                 550                 555                 560 
Arg Asp Thr Ser Asp Lys Tyr Leu Val Leu Ile Gln Met Phe Asn Lys
                565                 570                 575     
Asp Leu Asp Ala Val Arg Met Ile Tyr Ser Gln His Val Gln Glu Glu
            580                 585                 590         
Ala Glu Leu Gly Phe Ser Pro Val His Lys Asn Met Pro Thr Val Ala
        595                 600                 605             
Gly Gly Leu Arg Trp Ala Gln Glu Leu Arg Gln Arg Ile Gln Gly Pro
    610                 615                 620                 
Phe Ser Asn Phe Gly Arg Ile Thr His Pro Cys Met Glu Ser Ala Glu
625                 630                 635                 640 
Gly Lys Arg Met Gln Gln Lys Tyr Glu Asp Met Leu Ser Leu Leu Glu
                645                 650                 655     
Lys Tyr Glu Thr Arg Leu Tyr Glu Asp Trp Cys Arg Thr Val Ser Glu
            660                 665                 670         
Lys Ser Gln Tyr Asn Leu Ser Gln Pro Leu Leu Lys Arg Asp Pro Glu
        675                 680                 685             
Thr Lys Glu Ile Thr Ile Asn Phe Asn Pro Gln Leu Ile Ser Val Leu
    690                 695                 700                 
Lys Glu Met Ser Tyr Leu Glu Pro Arg Glu Met Lys His Met Pro Glu
705                 710                 715                 720 
Thr Ala Ala Ala Met Phe Ser Ser Arg Asp Phe Tyr Arg Gln Leu Val
                725                 730                 735     
Ala Asn Leu Glu Leu Met Ala Asn Trp Tyr Asn Lys Val Met Lys Thr
            740                 745                 750         
Leu Leu Glu Val Glu Phe Pro Leu Val Glu Glu Glu Leu Gln Asn Ile
        755                 760                 765             
Asp Leu Arg Leu Arg Ala Ala Glu Glu Thr Leu Asn Trp Lys Thr Glu
    770                 775                 780                 
Gly Ile Cys Asp Tyr Val Thr Glu Ile Thr Ser Ser Ile His Asp Leu
785                 790                 795                 800 
Glu Gln Arg Ile Gln Lys Thr Lys Asp Asn Val Glu Glu Ile Gln Asn
                805                 810                 815     
Ile Met Lys Thr Trp Val Thr Pro Ile Phe Lys Thr Lys Asp Gly Lys
            820                 825                 830         
Arg Glu Ser Leu Leu Ser Leu Asp Asp Arg His Asp Arg Met Glu Lys
        835                 840                 845             
Tyr Tyr Asn Leu Ile Lys Glu Ser Gly Leu Lys Ile His Ala Leu Val
    850                 855                 860                 
Gln Glu Asn Leu Gly Leu Phe Ser Ala Asp Pro Thr Ser Asn Ile Trp
865                 870                 875                 880 
Lys Thr Tyr Val Asn Ser Ile Asp Asn Leu Leu Leu Asn Gly Phe Phe
                885                 890                 895     
Leu Ala Ile Glu Cys Ser Leu Lys Tyr Leu Leu Glu Asn Thr Glu Cys
            900                 905                 910         
Lys Ala Gly Leu Thr Pro Ile Phe Glu Ala Gln Leu Ser Leu Ala Ile
        915                 920                 925             
Pro Glu Leu Val Phe Tyr Pro Ser Leu Glu Ser Gly Val Lys Gly Gly
    930                 935                 940                 
Phe Cys Asp Ile Val Glu Gly Leu Ile Thr Ser Ile Phe Arg Ile Pro
945                 950                 955                 960 
Ser Leu Val Pro Arg Leu Ser Pro Gln Asn Gly Ser Pro His Tyr Gln
                965                 970                 975     
Val Asp Leu Asp Gly Ile Pro Asp Leu Ala Asn Met Arg Arg Thr Leu
            980                 985                 990         
Met Glu Arg Val Gln Arg Met Met Gly Leu Cys Cys Gly Tyr Gln Ser
        995                 1000                1005            
Thr Phe Ser Gln Tyr Ser Tyr Leu Tyr Val Glu Asp Arg Lys Glu Val
    1010                1015                1020                
Leu Gly Gln Phe Leu Leu Tyr Gly His Ile Leu Thr Pro Glu Glu Ile
1025                1030                1035                1040
Glu Asp His Val Glu Asp Gly Ile Pro Glu Asn Pro Pro Leu Leu Ser
                1045                1050                1055    
Gln Phe Lys Val Gln Ile Asp Ser Tyr Glu Thr Leu Tyr Glu Glu Val
            1060                1065                1070        
Cys Arg Leu Glu Pro Ile Lys Val Phe Asp Gly Trp Met Lys Ile Asp
        1075                1080                1085            
Ile Arg Pro Phe Lys Ala Ser Leu Leu Asn Ile Ile Lys Arg Trp Ser
    1090                1095                1100                
Leu Leu Phe Lys Gln His Leu Val Asp His Val Thr His Ser Leu Ala
1105                1110                1115                1120
Asn Leu Asp Ala Phe Ile Lys Lys Ser Glu Ser Gly Leu Leu Lys Lys
                1125                1130                1135    
Val Glu Lys Gly Asp Phe Gln Gly Leu Val Glu Ile Met Gly His Leu
            1140                1145                1150        
Met Ala Val Lys Glu Arg Gln Ser Asn Thr Asp Glu Met Phe Glu Pro
        1155                1160                1165            
Leu Lys Gln Thr Ile Glu Leu Leu Lys Thr Tyr Glu Gln Glu Leu Pro
    1170                1175                1180                
Glu Thr Val Phe Lys Gln Leu Glu Glu Leu Pro Glu Lys Trp Asn Asn
1185                1190                1195                1200
Ile Lys Lys Val Ala Ile Thr Val Lys Gln Gln Val Ala Pro Leu Gln
                1205                1210                1215    
Ala Asn Glu Val Thr Leu Leu Arg Gln Arg Cys Thr Ala Phe Asp Ala
            1220                1225                1230        
Glu Gln Gln Gln Phe Trp Glu Gln Phe His Lys Glu Ala Pro Phe Arg
        1235                1240                1245            
Phe Asp Ser Ile His Pro His Gln Met Leu Asp Ala Arg His Ile Glu
    1250                1255                1260                
Ile Gln Gln Met Glu Ser Thr Met Ala Ser Ile Ser Glu Ser Ala Ser
1265                1270                1275                1280
Leu Phe Glu Val Asn Val Pro Asp Tyr Lys Gln Leu Arg Gln Cys Arg
                1285                1290                1295    
Lys Glu Val Cys Gln Leu Lys Glu Leu Trp Asp Thr Ile Gly Met Val
            1300                1305                1310        
Thr Ser Ser Ile His Ala Trp Glu Thr Thr Pro Trp Arg Asn Ile Asn
        1315                1320                1325            
Val Glu Ala Met Glu Leu Glu Cys Lys Gln Phe Ala Arg His Ile Arg
    1330                1335                1340                
Asn Leu Asp Lys Glu Val Arg Ala Trp Asp Ala Phe Thr Gly Leu Glu
1345                1350                1355                1360
Ser Thr Val Trp Asn Thr Leu Ser Ser Leu Arg Ala Val Ala Glu Leu
                1365                1370                1375    
Gln Asn Pro Ala Ile Arg Glu Arg His Trp Arg Gln Leu Met Gln Ala
            1380                1385                1390        
Thr Gly Val Ser Phe Thr Met Asp Gln Asp Thr Thr Leu Ala His Leu
        1395                1400                1405            
Leu Gln Leu Gln Leu His His Tyr Glu Asp Glu Val Arg Gly Ile Val
    1410                1415                1420                
Asp Lys Ala Ala Lys Glu Met Gly Met Glu Lys Thr Leu Lys Glu Leu
1425                1430                1435                1440
Gln Thr Thr Trp Ala Gly Met Glu Phe Gln Tyr Glu Pro His Pro Arg
                1445                1450                1455    
Thr Asn Val Pro Leu Leu Cys Ser Asp Glu Asp Leu Ile Glu Val Leu
            1460                1465                1470        
Glu Asp Asn Gln Val Gln Leu Gln Asn Leu Val Met Ser Lys Tyr Val
        1475                1480                1485            
Ala Phe Phe Leu Glu Glu Val Ser Gly Trp Gln Lys Lys Leu Ser Thr
    1490                1495                1500                
Val Asp Ala Val Ile Ser Ile Trp Phe Glu Val Gln Arg Thr Trp Thr
1505                1510                1515                1520
His Leu Glu Ser Ile Phe Thr Gly Ser Glu Asp Ile Arg Ala Gln Leu
                1525                1530                1535    
Pro Gln Asp Ser Lys Arg Phe Glu Gly Ile Asp Ile Asp Phe Lys Glu
            1540                1545                1550        
Leu Ala Tyr Asp Ala Gln Lys Ile Pro Asn Val Val Gln Thr Thr Asn
        1555                1560                1565            
Lys Pro Gly Leu Tyr Glu Lys Leu Glu Asp Ile Gln Gly Arg Leu Cys
    1570                1575                1580                
Leu Cys Glu Lys Ala Leu Ala Glu Tyr Leu Asp Thr Lys Arg Leu Ala
1585                1590                1595                1600
Phe Pro Arg Phe Tyr Phe Leu Ser Ser Ser Asp Leu Leu Asp Ile Leu
                1605                1610                1615    
Ser Asn Gly Thr Ala Pro Gln Gln Val Gln Arg His Leu Ser Lys Leu
            1620                1625                1630        
Phe Asp Asn Met Ala Lys Met Arg Phe Gln Leu Asp Ala Ser Gly Glu
        1635                1640                1645            
Pro Thr Lys Thr Ser Leu Gly Met Tyr Ser Lys Glu Glu Glu Tyr Val
    1650                1655                1660                
Ala Phe Ser Glu Pro Cys Asp Cys Ser Gly Gln Val Glu Ile Trp Leu
1665                1670                1675                1680
Asn His Val Leu Gly His Met Lys Ala Thr Val Arg His Glu Met Thr
                1685                1690                1695    
Glu Gly Val Thr Ala Tyr Glu Glu Lys Pro Arg Glu Gln Trp Leu Phe
            1700                1705                1710        
Asp His Pro Ala Gln Val Ala Leu Thr Cys Thr Gln Ile Trp Trp Thr
        1715                1720                1725            
Thr Glu Val Gly Met Ala Phe Ala Arg Leu Glu Glu Gly Tyr Glu Ser
    1730                1735                1740                
Ala Met Lys Asp Tyr Tyr Lys Lys Gln Val Ala Gln Leu Lys Thr Leu
1745                1750                1755                1760
Ile Thr Met Leu Ile Gly Gln Leu Ser Lys Gly Asp Arg Gln Lys Ile
                1765                1770                1775    
Met Thr Ile Cys Thr Ile Asp Val His Ala Arg Asp Val Val Ala Lys
            1780                1785                1790        
Met Ile Ala Gln Lys Val Asp Asn Ala Gln Ala Phe Leu Trp Leu Ser
        1795                1800                1805            
Gln Leu Arg His Arg Trp Asp Asp Glu Val Lys His Cys Phe Ala Asn
    1810                1815                1820                
Ile Cys Asp Ala Gln Phe Leu Tyr Ser Tyr Glu Tyr Leu Gly Asn Thr
1825                1830                1835                1840
Pro Arg Leu Val Ile Thr Pro Leu Thr Asp Arg Cys Tyr Ile Thr Leu
                1845                1850                1855    
Thr Gln Ser Leu His Leu Thr Met Ser Gly Ala Pro Ala Gly Pro Ala
            1860                1865                1870        
Gly Thr Gly Lys Thr Glu Thr Thr Lys Asp Leu Gly Arg Ala Leu Gly
        1875                1880                1885            
Ile Leu Val Tyr Val Phe Asn Cys Ser Glu Gln Met Asp Tyr Lys Ser
    1890                1895                1900                
Cys Gly Asn Ile Tyr Lys Gly Leu Ala Gln Thr Gly Ala Trp Gly Cys
1905                1910                1915                1920
Phe Asp Glu Phe Asn Arg Ile Ser Val Glu Val Leu Ser Val Val Ala
                1925                1930                1935    
Val Gln Val Lys Ser Ile Gln Asp Ala Ile Arg Asp Lys Lys Gln Trp
            1940                1945                1950        
Phe Ser Phe Leu Gly Glu Glu Ile Ser Leu Asn Pro Ser Val Gly Ile
        1955                1960                1965            
Phe Ile Thr Met Asn Pro Gly Tyr Ala Gly Arg Thr Glu Leu Pro Glu
    1970                1975                1980                
Asn Leu Lys Ser Leu Phe Arg Pro Cys Ala Met Val Val Pro Asp Phe
1985                1990                1995                2000
Glu Leu Ile Cys Glu Ile Met Leu Val Ala Glu Gly Phe Ile Glu Ala
                2005                2010                2015    
Gln Ser Leu Ala Arg Lys Phe Ile Thr Leu Tyr Gln Leu Cys Lys Glu
            2020                2025                2030        
Leu Leu Ser Lys Gln Asp His Tyr Asp Trp Gly Leu Arg Ala Ile Lys
        2035                2040                2045            
Ser Val Leu Val Val Ala Gly Ser Leu Lys Arg Gly Asp Pro Asp Arg
    2050                2055                2060                
Pro Glu Asp Gln Val Leu Met Arg Ser Leu Arg Asp Phe Asn Ile Pro
2065                2070                2075                2080
Lys Ile Val Thr Asp Asp Met Pro Ile Phe Met Gly Leu Ile Gly Asp
                2085                2090                2095    
Leu Phe Pro Ala Leu Asp Val Pro Arg Arg Arg Asp Pro Asn Phe Glu
            2100                2105                2110        
Ala Leu Val Arg Lys Ala Ile Val Asp Leu Lys Leu Gln Ala Glu Asp
        2115                2120                2125            
Asn Phe Val Leu Lys Val Val Gln Leu Glu Glu Leu Leu Ala Val Arg
    2130                2135                2140                
His Ser Val Phe Val Val Gly Gly Ala Gly Thr Gly Lys Ser Gln Val
2145                2150                2155                2160
Leu Arg Ser Leu His Lys Thr Tyr Gln Ile Met Lys Arg Arg Pro Val
                2165                2170                2175    
Trp Thr Asp Leu Asn Pro Lys Ala Val Thr Asn Asp Glu Leu Phe Gly
            2180                2185                2190        
Ile Ile Asn Pro Ala Thr Gly Glu Trp Lys Asp Gly Leu Phe Ser Ser
        2195                2200                2205            
Ile Met Arg Glu Leu Ala Asn Ile Thr His Asp Gly Pro Lys Trp Ile
    2210                2215                2220                
Leu Leu Asp Gly Asp Ile Asp Pro Met Trp Ile Glu Ser Leu Asn Thr
2225                2230                2235                2240
Val Met Asp Asp Asn Lys Val Leu Thr Leu Ala Ser Asn Glu Arg Ile
                2245                2250                2255    
Pro Leu Asn Pro Thr Met Lys Leu Leu Phe Glu Ile Ser His Leu Arg
            2260                2265                2270        
Thr Ala Thr Pro Ala Thr Val Ser Arg Ala Gly Ile Leu Tyr Ile Asn
        2275                2280                2285            
Pro Ala Asp Leu Gly Trp Asn Pro Pro Val Ser Ser Trp Ile Glu Lys
    2290                2295                2300                
Arg Glu Ile Gln Thr Glu Arg Ala Asn Leu Thr Ile Leu Phe Asp Lys
2305                2310                2315                2320
Tyr Leu Pro Thr Cys Leu Asp Thr Leu Arg Thr Arg Phe Lys Lys Ile
                2325                2330                2335    
Ile Pro Ile Pro Glu Gln Ser Met Val Gln Met Val Cys His Leu Leu
            2340                2345                2350        
Glu Cys Leu Leu Thr Thr Glu Asp Ile Pro Ala Asp Cys Pro Lys Glu
        2355                2360                2365            
Ile Tyr Glu His Tyr Phe Val Phe Ala Ala Ile Trp Ala Phe Gly Gly
    2370                2375                2380                
Ala Met Val Gln Asp Gln Leu Val Asp Tyr Arg Ala Glu Phe Ser Lys
2385                2390                2395                2400
Trp Trp Leu Thr Glu Phe Lys Thr Val Lys Phe Pro Ser Gln Gly Thr
                2405                2410                2415    
Ile Phe Asp Tyr Tyr Ile Asp Pro Glu Thr Lys Lys Phe Glu Pro Trp
            2420                2425                2430        
Ser Lys Leu Val Pro Gln Phe Glu Phe Asp Pro Glu Met Pro Leu Gln
        2435                2440                2445            
Ala Cys Leu Val His Thr Ser Glu Thr Ile Arg Val Cys Tyr Phe Met
    2450                2455                2460                
Glu Arg Leu Met Ala Arg Gln Arg Pro Val Met Leu Val Gly Thr Ala
2465                2470                2475                2480
Gly Thr Gly Lys Ser Val Leu Val Gly Ala Lys Leu Ala Ser Leu Asp
                2485                2490                2495    
Pro Glu Ala Tyr Leu Val Lys Asn Leu Pro Phe Asn Tyr Tyr Thr Thr
            2500                2505                2510        
Ser Ala Met Leu Gln Ala Val Leu Glu Lys Pro Leu Glu Lys Lys Ala
        2515                2520                2525            
Gly Arg Asn Tyr Gly Pro Pro Gly Asn Lys Lys Leu Ile Tyr Phe Ile
    2530                2535                2540                
Asp Asp Met Asn Met Pro Glu Val Asp Ala Tyr Gly Thr Val Gln Pro
2545                2550                2555                2560
His Thr Ile Ile Arg Gln His Leu Asp Tyr Gly His Trp Tyr Asp Arg
                2565                2570                2575    
Ser Lys Leu Ser Leu Lys Glu Ile Thr Asn Val Gln Tyr Val Ser Cys
            2580                2585                2590        
Met Asn Pro Thr Ala Gly Ser Phe Thr Ile Asn Pro Arg Leu Gln Arg
        2595                2600                2605            
His Phe Ser Val Phe Val Leu Ser Phe Pro Gly Ala Asp Ala Leu Ser
    2610                2615                2620                
Ser Ile Tyr Ser Ile Ile Leu Thr Gln His Leu Lys Leu Gly Asn Phe
2625                2630                2635                2640
Pro Ala Ser Leu Gln Lys Ser Ile Pro Pro Leu Ile Asp Leu Ala Leu
                2645                2650                2655    
Ala Phe His Gln Lys Ile Ala Thr Thr Phe Leu Pro Thr Gly Ile Lys
            2660                2665                2670        
Phe His Tyr Ile Phe Asn Leu Arg Asp Phe Ala Asn Ile Phe Gln Gly
        2675                2680                2685            
Ile Leu Phe Ser Ser Val Glu Cys Val Lys Ser Thr Trp Asp Leu Ile
    2690                2695                2700                
Arg Leu Tyr Leu His Glu Ser Asn Arg Val Tyr Arg Asp Lys Met Val
2705                2710                2715                2720
Glu Glu Lys Asp Phe Asp Leu Phe Asp Lys Ile Gln Thr Glu Val Leu
                2725                2730                2735    
Lys Lys Thr Phe Asp Asp Ile Glu Asp Pro Val Glu Gln Thr Gln Ser
            2740                2745                2750        
Pro Asn Leu Tyr Cys His Phe Ala Asn Gly Ile Gly Glu Pro Lys Tyr
        2755                2760                2765            
Met Pro Val Gln Ser Trp Glu Leu Leu Thr Gln Thr Leu Val Glu Ala
    2770                2775                2780                
Leu Glu Asn His Asn Glu Val Asn Thr Val Met Asp Leu Val Leu Phe
2785                2790                2795                2800
Glu Asp Ala Met Arg His Val Cys His Ile Asn Arg Ile Leu Glu Ser
                2805                2810                2815    
Pro Arg Gly Asn Ala Leu Leu Val Gly Val Gly Gly Ser Gly Lys Gln
            2820                2825                2830        
Ser Leu Thr Arg Leu Ala Ala Phe Ile Ser Ser Met Asp Val Phe Gln
        2835                2840                2845            
Ile Thr Leu Arg Lys Gly Tyr Gln Ile Gln Asp Phe Lys Met Asp Leu
    2850                2855                2860                
Ala Ser Leu Cys Leu Lys Ala Gly Val Lys Asn Leu Asn Thr Val Phe
2865                2870                2875                2880
Leu Met Thr Asp Ala Gln Val Ala Asp Glu Arg Phe Leu Val Leu Ile
                2885                2890                2895    
Asn Asp Leu Leu Ala Ser Gly Glu Ile Pro Asp Leu Tyr Ser Asp Asp
            2900                2905                2910        
Glu Val Glu Asn Ile Ile Ser Asn Val Arg Asn Glu Val Lys Ser Gln
        2915                2920                2925            
Gly Leu Val Asp Asn Arg Glu Asn Cys Trp Lys Phe Phe Ile Asp Arg
    2930                2935                2940                
Ile Arg Arg Gln Leu Lys Val Thr Leu Cys Phe Ser Pro Val Gly Asn
2945                2950                2955                2960
Lys Leu Arg Val Arg Ser Arg Lys Phe Pro Ala Ile Val Asn Cys Thr
                2965                2970                2975    
Ala Ile His Trp Phe His Glu Trp Pro Gln Gln Ala Leu Glu Ser Val
            2980                2985                2990        
Ser Leu Arg Phe Leu Gln Asn Thr Glu Gly Ile Glu Pro Thr Val Lys
        2995                3000                3005            
Gln Ser Ile Ser Lys Phe Met Ala Phe Val His Thr Ser Val Asn Gln
    3010                3015                3020                
Thr Ser Gln Ser Tyr Leu Ser Asn Glu Gln Arg Tyr Asn Tyr Thr Thr
3025                3030                3035                3040
Pro Lys Ser Phe Leu Glu Phe Ile Arg Leu Tyr Gln Ser Leu Leu His
                3045                3050                3055    
Arg His Arg Lys Glu Leu Lys Cys Lys Thr Glu Arg Leu Glu Asn Gly
            3060                3065                3070        
Leu Leu Lys Leu His Ser Thr Ser Ala Gln Val Asp Asp Leu Lys Ala
        3075                3080                3085            
Lys Leu Ala Ala Gln Glu Val Glu Leu Lys Gln Lys Asn Glu Asp Ala
    3090                3095                3100                
Asp Lys Leu Ile Gln Val Val Gly Val Glu Thr Asp Lys Val Ser Arg
3105                3110                3115                3120
Glu Lys Ala Met Ala Asp Glu Glu Glu Gln Lys Val Ala Val Ile Met
                3125                3130                3135    
Leu Glu Val Lys Gln Lys Gln Lys Asp Cys Glu Glu Asp Leu Ala Lys
            3140                3145                3150        
Ala Glu Pro Ala Leu Thr Ala Ala Gln Ala Ala Leu Asn Thr Leu Asn
        3155                3160                3165            
Lys Thr Asn Leu Thr Glu Leu Lys Ser Phe Gly Ser Pro Pro Leu Ala
    3170                3175                3180                
Val Ser Asn Val Ser Ala Ala Val Met Val Leu Met Ala Pro Arg Gly
3185                3190                3195                3200
Arg Val Pro Lys Asp Arg Ser Trp Lys Ala Ala Lys Val Thr Met Ala
                3205                3210                3215    
Lys Val Asp Gly Phe Leu Asp Ser Leu Ile Asn Phe Asn Lys Glu Asn
            3220                3225                3230        
Ile His Glu Asn Cys Leu Lys Ala Ile Arg Pro Tyr Leu Gln Asp Pro
        3235                3240                3245            
Glu Phe Asn Pro Glu Phe Val Ala Thr Lys Ser Tyr Ala Ala Ala Gly
    3250                3255                3260                
Leu Cys Ser Trp Val Ile Asn Ile Val Arg Phe Tyr Glu Val Phe Cys
3265                3270                3275                3280
Asp Val Glu Pro Lys Arg Gln Ala Leu Asn Lys Ala Thr Ala Asp Leu
                3285                3290                3295    
Thr Ala Ala Gln Glu Lys Leu Ala Ala Ile Lys Ala Lys Ile Ala His
            3300                3305                3310        
Leu Asn Glu Asn Leu Ala Lys Leu Thr Ala Arg Phe Glu Lys Ala Thr
        3315                3320                3325            
Ala Asp Lys Leu Lys Cys Gln Gln Glu Ala Glu Val Thr Ala Val Thr
    3330                3335                3340                
Ile Ser Leu Ala Asn Arg Leu Val Gly Gly Leu Ala Ser Glu Asn Val
3345                3350                3355                3360
Arg Trp Ala Asp Ala Val Gln Asn Phe Lys Gln Gln Glu Arg Thr Leu
                3365                3370                3375    
Cys Gly Asp Ile Leu Leu Ile Thr Ala Phe Ile Ser Tyr Leu Gly Phe
            3380                3385                3390        
Phe Thr Lys Lys Tyr Arg Gln Ser Leu Leu Asp Arg Thr Trp Arg Pro
        3395                3400                3405            
Tyr Leu Ser Gln Leu Lys Thr Pro Ile Pro Val Thr Pro Ala Leu Asp
    3410                3415                3420                
Pro Leu Arg Met Leu Met Asp Asp Ala Asp Val Ala Ala Trp Gln Asn
3425                3430                3435                3440
Glu Gly Leu Pro Ala Asp Arg Met Ser Val Glu Asn Ala Thr Ile Leu
                3445                3450                3455    
Ile Asn Cys Glu Arg Trp Pro Leu Met Val Asp Pro Gln Leu Gln Gly
            3460                3465                3470        
Ile Lys Trp Ile Lys Asn Lys Tyr Gly Glu Asp Leu Arg Val Thr Gln
        3475                3480                3485            
Ile Gly Gln Lys Gly Tyr Leu Gln Ile Ile Glu Gln Ala Leu Glu Ala
    3490                3495                3500                
Gly Ala Val Val Leu Ile Glu Asn Leu Glu Glu Ser Ile Asp Pro Val
3505                3510                3515                3520
Leu Gly Pro Leu Leu Gly Arg Glu Val Ile Lys Lys Gly Arg Phe Ile
                3525                3530                3535    
Lys Ile Gly Asp Lys Glu Cys Glu Tyr Asn Pro Lys Phe Arg Leu Ile
            3540                3545                3550        
Leu His Thr Lys Leu Ala Asn Pro His Tyr Gln Pro Glu Leu Gln Ala
        3555                3560                3565            
Gln Ala Thr Leu Ile Asn Phe Thr Val Thr Arg Asp Gly Leu Glu Asp
    3570                3575                3580                
Gln Leu Leu Ala Ala Val Val Ser Met Glu Arg Pro Asp Leu Glu Gln
3585                3590                3595                3600
Leu Lys Ser Asp Leu Thr Lys Gln Gln Asn Gly Phe Lys Ile Thr Leu
                3605                3610                3615    
Lys Thr Leu Glu Asp Ser Leu Leu Ser Arg Leu Ser Ser Ala Ser Gly
            3620                3625                3630        
Asn Phe Leu Gly Glu Thr Val Leu Val Glu Asn Leu Glu Ile Thr Lys
        3635                3640                3645            
Gln Thr Ala Ala Glu Val Glu Lys Lys Val Gln Glu Ala Lys Val Thr
    3650                3655                3660                
Glu Val Lys Ile Asn Glu Ala Arg Glu His Tyr Arg Pro Thr Ala Ala
3665                3670                3675                3680
Arg Ala Ser Leu Leu Tyr Phe Ile Met Asn Asp Leu Ser Lys Ile His
                3685                3690                3695    
Pro Met Tyr Gln Phe Ser Leu Lys Ala Phe Ser Ile Val Phe Gln Lys
            3700                3705                3710        
Ala Val Glu Arg Ala Ala Pro Asp Glu Ser Leu Arg Glu Arg Val Ala
        3715                3720                3725            
Asn Leu Ile Asp Ser Ile Thr Phe Ser Val Tyr Gln Tyr Thr Ile Arg
    3730                3735                3740                
Gly Leu Phe Glu Cys Asp Lys Leu Thr Tyr Leu Ala Gln Leu Thr Phe
3745                3750                3755                3760
Gln Ile Leu Leu Met Asn Arg Glu Val Asn Ala Val Glu Leu Asp Phe
                3765                3770                3775    
Leu Leu Arg Ser Pro Val Gln Thr Gly Thr Ala Ser Pro Val Glu Phe
            3780                3785                3790        
Leu Ser His Gln Ala Trp Gly Ala Val Lys Val Leu Ser Ser Met Glu
        3795                3800                3805            
Glu Phe Ser Asn Leu Asp Arg Asp Ile Glu Gly Ser Ala Lys Ser Trp
    3810                3815                3820                
Lys Lys Phe Val Glu Ser Glu Cys Pro Glu Lys Glu Lys Leu Pro Gln
3825                3830                3835                3840
Glu Trp Lys Asn Lys Thr Ala Leu Gln Arg Leu Cys Met Leu Arg Ala
                3845                3850                3855    
Met Arg Pro Asp Arg Met Thr Tyr Ala Leu Arg Asp Phe Val Glu Glu
            3860                3865                3870        
Lys Leu Gly Ser Lys Tyr Val Val Gly Arg Ala Leu Asp Phe Ala Thr
        3875                3880                3885            
Ser Phe Glu Glu Ser Gly Pro Ala Thr Pro Met Phe Phe Ile Leu Ser
    3890                3895                3900                
Pro Gly Val Asp Pro Leu Lys Asp Val Glu Ser Gln Gly Arg Lys Leu
3905                3910                3915                3920
Gly Tyr Thr Phe Asn Asn Gln Asn Phe His Asn Val Ser Leu Gly Gln
                3925                3930                3935    
Gly Gln Glu Val Val Ala Glu Ala Ala Leu Asp Leu Ala Ala Lys Lys
            3940                3945                3950        
Gly His Trp Val Ile Leu Gln Asn Ile His Leu Val Ala Lys Trp Leu
        3955                3960                3965            
Ser Thr Leu Glu Lys Lys Leu Glu Glu His Ser Glu Asn Ser His Pro
    3970                3975                3980                
Glu Phe Arg Val Phe Met Ser Ala Glu Pro Ala Pro Ser Pro Glu Gly
3985                3990                3995                4000
His Ile Ile Pro Gln Gly Ile Leu Glu Asn Ser Ile Lys Ile Thr Asn
                4005                4010                4015    
Glu Pro Pro Thr Gly Met His Ala Asn Leu His Lys Ala Leu Asp Asn
            4020                4025                4030        
Phe Thr Gln Asp Thr Leu Glu Met Cys Ser Arg Glu Thr Glu Phe Lys
        4035                4040                4045            
Ser Ile Leu Phe Ala Leu Cys Tyr Phe His Ala Val Val Ala Glu Arg
    4050                4055                4060                
Arg Lys Phe Gly Pro Gln Gly Trp Asn Arg Ser Tyr Pro Phe Asn Thr
4065                4070                4075                4080
Gly Asp Leu Thr Ile Ser Val Asn Val Leu Tyr Asn Phe Leu Glu Ala
                4085                4090                4095    
Asn Ala Lys Val Pro Tyr Asp Asp Leu Arg Tyr Leu Phe Gly Glu Ile
            4100                4105                4110        
Met Tyr Gly Gly His Ile Thr Asp Asp Trp Asp Arg Arg Leu Cys Arg
        4115                4120                4125            
Thr Tyr Leu Gly Glu Phe Ile Arg Pro Glu Met Leu Glu Gly Glu Leu
    4130                4135                4140                
Ser Leu Ala Pro Gly Phe Pro Leu Pro Gly Asn Met Asp Tyr Asn Gly
4145                4150                4155                4160
Tyr His Gln Tyr Ile Asp Ala Glu Leu Pro Pro Glu Ser Pro Tyr Leu
                4165                4170                4175    
Tyr Gly Leu His Pro Asn Ala Glu Ile Gly Phe Leu Thr Gln Thr Ser
            4180                4185                4190        
Glu Lys Leu Phe Arg Thr Val Leu Glu Leu Gln Pro Arg Asp Ser Gln
        4195                4200                4205            
Ala Arg Asp Gly Ala Gly Ala Thr Arg Glu Glu Lys Val Lys Ala Leu
    4210                4215                4220                
Leu Glu Glu Ile Leu Glu Arg Val Thr Asp Glu Phe Asn Ile Pro Glu
4225                4230                4235                4240
Leu Met Ala Lys Val Glu Glu Arg Thr Pro Tyr Ile Val Val Ala Phe
                4245                4250                4255    
Gln Glu Cys Gly Arg Met Asn Ile Leu Thr Arg Glu Ile Gln Arg Ser
            4260                4265                4270        
Leu Arg Glu Leu Glu Leu Gly Leu Lys Gly Glu Leu Thr Met Thr Ser
        4275                4280                4285            
His Met Glu Asn Leu Gln Asn Ala Leu Tyr Phe Asp Met Val Pro Glu
    4290                4295                4300                
Ser Trp Ala Arg Arg Ala Tyr Pro Ser Thr Ala Gly Leu Ala Ala Trp
4305                4310                4315                4320
Phe Pro Asp Leu Leu Asn Arg Ile Lys Glu Leu Glu Ala Trp Thr Gly
                4325                4330                4335    
Asp Phe Thr Met Pro Ser Thr Val Trp Leu Thr Gly Phe Phe Asn Pro
            4340                4345                4350        
Gln Ser Phe Leu Thr Ala Ile Met Gln Ser Thr Ala Arg Lys Asn Glu
        4355                4360                4365            
Trp Pro Leu Asp Gln Ile Ala Leu Gln Cys Asp Met Thr Lys Lys Asn
    4370                4375                4380                
Arg Glu Glu Phe Arg Ser Pro Pro Arg Glu Gly Ala Tyr Ile His Gly
4385                4390                4395                4400
Leu Phe Met Glu Gly Ala Cys Trp Asp Thr Gln Ala Gly Ile Ile Thr
                4405                4410                4415    
Glu Ala Lys Leu Lys Asp Leu Thr Pro Pro Met Pro Val Met Phe Ile
            4420                4425                4430        
Lys Ala Ile Pro Ala Asp Lys Gln Asp Cys Arg Ser Val Tyr Ser Cys
        4435                4440                4445            
Pro Val Tyr Lys Thr Ser Gln Arg Gly Pro Thr Tyr Val Trp Thr Phe
    4450                4455                4460                
Asn Leu Lys Thr Lys Glu Asn Pro Ser Lys Trp Val Leu Ala Gly Val
4465                4470                4475                4480
Ala Leu Leu Leu Gln Ile
                4485    


<210> 8045
<211> 693
<212> PRT
<213> Homo sapiens

<400> 8045
Met Ala Gln Gly Ser His Gln Ile Asp Phe Gln Val Leu His Asp Leu
 1               5                  10                  15      
Arg Gln Lys Phe Pro Glu Val Pro Glu Val Val Val Ser Arg Cys Met
            20                  25                  30          
Leu Gln Asn Asn Asn Asn Leu Asp Ala Cys Cys Ala Val Leu Ser Gln
        35                  40                  45              
Glu Ser Thr Arg Tyr Leu Tyr Gly Glu Gly Asp Leu Asn Phe Ser Asp
    50                  55                  60                  
Asp Ser Gly Ile Ser Gly Leu Arg Asn His Met Thr Ser Leu Asn Leu
65                  70                  75                  80  
Asp Leu Gln Ser Gln Asn Ile Tyr His His Gly Arg Glu Gly Ser Arg
                85                  90                  95      
Met Asn Gly Ser Arg Thr Leu Thr His Ser Ile Ser Asp Gly Gln Leu
            100                 105                 110         
Gln Gly Gly Gln Ser Asn Ser Glu Leu Phe Gln Gln Glu Pro Gln Thr
        115                 120                 125             
Ala Pro Ala Gln Val Pro Gln Gly Phe Asn Val Phe Gly Met Ser Ser
    130                 135                 140                 
Ser Ser Gly Ala Ser Asn Ser Ala Pro His Leu Gly Phe His Leu Gly
145                 150                 155                 160 
Ser Lys Gly Thr Ser Ser Leu Ser Gln Gln Thr Pro Arg Phe Asn Pro
                165                 170                 175     
Ile Met Val Thr Leu Ala Pro Asn Ile Gln Thr Gly Arg Asn Thr Pro
            180                 185                 190         
Thr Ser Leu His Ile His Gly Val Pro Pro Pro Val Leu Asn Ser Pro
        195                 200                 205             
Gln Gly Asn Ser Ile Tyr Ile Arg Pro Tyr Ile Thr Thr Pro Gly Gly
    210                 215                 220                 
Thr Thr Arg Gln Thr Gln Gln His Ser Gly Trp Val Ser Gln Phe Asn
225                 230                 235                 240 
Pro Met Asn Pro Gln Gln Val Tyr Gln Pro Ser Gln Pro Gly Pro Trp
                245                 250                 255     
Thr Thr Cys Pro Ala Ser Asn Pro Leu Ser His Thr Ser Ser Gln Gln
            260                 265                 270         
Pro Asn Gln Gln Gly His Gln Thr Ser His Val Tyr Met Pro Ile Ser
        275                 280                 285             
Ser Pro Thr Thr Ser Gln Pro Pro Thr Ile His Ser Ser Gly Ser Ser
    290                 295                 300                 
Gln Ser Ser Ala His Ser Gln Tyr Asn Ile Gln Asn Ile Ser Thr Gly
305                 310                 315                 320 
Pro Arg Lys Asn Gln Ile Glu Ile Lys Leu Glu Pro Pro Gln Arg Asn
                325                 330                 335     
Asn Ser Ser Lys Leu Arg Ser Ser Gly Pro Arg Thr Ser Ser Thr Ser
            340                 345                 350         
Ser Ser Val Asn Ser Gln Thr Leu Asn Arg Asn Gln Pro Thr Val Tyr
        355                 360                 365             
Ile Ala Ala Ser Pro Pro Asn Thr Asp Glu Leu Met Ser Arg Ser Gln
    370                 375                 380                 
Pro Lys Val Tyr Ile Ser Ala Asn Ala Ala Thr Gly Asp Glu Gln Val
385                 390                 395                 400 
Met Arg Asn Gln Pro Thr Leu Phe Ile Ser Thr Asn Ser Gly Ala Ser
                405                 410                 415     
Ala Ala Ser Arg Asn Met Ser Gly Gln Val Ser Met Gly Pro Ala Phe
            420                 425                 430         
Ile His His His Pro Pro Lys Ser Arg Ala Ile Gly Asn Asn Ser Ala
        435                 440                 445             
Thr Ser Pro Arg Val Val Val Thr Gln Pro Asn Thr Lys Tyr Thr Phe
    450                 455                 460                 
Lys Ile Thr Val Ser Pro Asn Lys Pro Pro Ala Val Ser Pro Gly Val
465                 470                 475                 480 
Val Ser Pro Thr Phe Glu Leu Thr Asn Leu Leu Asn His Pro Asp His
                485                 490                 495     
Tyr Val Glu Thr Glu Asn Ile Gln His Leu Thr Asp Pro Thr Leu Ala
            500                 505                 510         
His Val Asp Arg Ile Ser Glu Thr Arg Lys Leu Ser Met Gly Ser Asp
        515                 520                 525             
Asp Ala Ala Tyr Thr Gln Ala Leu Leu Val His Gln Lys Ala Arg Met
    530                 535                 540                 
Glu Arg Leu Gln Arg Glu Leu Glu Ile Gln Lys Lys Lys Leu Asp Lys
545                 550                 555                 560 
Leu Lys Ser Glu Val Asn Glu Met Glu Asn Asn Leu Thr Arg Arg Arg
                565                 570                 575     
Leu Lys Arg Ser Asn Ser Ile Ser Gln Ile Pro Ser Leu Glu Glu Met
            580                 585                 590         
Gln Gln Leu Arg Ser Cys Asn Arg Gln Leu Gln Ile Asp Ile Asp Cys
        595                 600                 605             
Leu Thr Lys Glu Ile Asp Leu Phe Gln Ala Arg Gly Pro His Phe Asn
    610                 615                 620                 
Pro Ser Ala Ile His Asn Phe Tyr Asp Asn Ile Gly Phe Val Gly Pro
625                 630                 635                 640 
Val Pro Pro Lys Pro Lys Asp Gln Arg Ser Ile Ile Lys Thr Pro Lys
                645                 650                 655     
Thr Gln Asp Thr Glu Asp Asp Glu Gly Ala Gln Trp Asn Cys Thr Ala
            660                 665                 670         
Cys Thr Phe Leu Asn His Pro Ala Leu Ile Arg Cys Glu Gln Cys Glu
        675                 680                 685             
Met Pro Arg His Phe
    690             


<210> 8046
<211> 404
<212> PRT
<213> Homo sapiens

<400> 8046
Met Asn Gly Tyr Ala Glu Phe Pro Pro Ser Pro Ser Asn Pro Thr Lys
 1               5                  10                  15      
Glu Pro Val Glu Pro Gln Pro Ser Gln Val Pro Leu Gln Glu Asp Val
            20                  25                  30          
Asp Met Ser Ser Gly Ser Ser Gly His Glu Thr Asn Glu Asn Cys Ser
        35                  40                  45              
Thr Gly Arg Asp Ser Gln Gly Ser Asp Cys Asp Asp Ser Gly Lys Glu
    50                  55                  60                  
Leu Gly Met Leu Val Glu Pro Pro Asp Ala Arg Gln Ser Pro Asp Thr
65                  70                  75                  80  
Phe Ser Leu Met Met Ala Lys Ser Glu His Asn Pro Ser Thr Ser Gly
                85                  90                  95      
Cys Ser Ser Asp Gln Ser Ser Lys Val Asp Thr His Lys Glu Leu Ile
            100                 105                 110         
Lys Thr Leu Lys Glu Leu Lys Val His Leu Pro Ala Asp Lys Lys Ala
        115                 120                 125             
Lys Gly Lys Ala Ser Thr Leu Ala Thr Leu Lys Tyr Ala Leu Arg Ser
    130                 135                 140                 
Val Lys Gln Val Lys Ala Asn Glu Glu Tyr Tyr Gln Leu Leu Met Ser
145                 150                 155                 160 
Ser Glu Gly His Pro Cys Gly Ala Asp Val Pro Ser Tyr Thr Val Glu
                165                 170                 175     
Glu Met Glu Ser Val Thr Ser Glu His Ile Val Lys Asn Ala Asp Met
            180                 185                 190         
Phe Ala Val Ala Val Ser Leu Val Ser Gly Lys Ile Leu Tyr Ile Ser
        195                 200                 205             
Asp Gln Val Ala Ser Ile Phe His Cys Lys Arg Asp Ala Phe Ser Asp
    210                 215                 220                 
Ala Lys Phe Val Glu Phe Leu Ala Pro His Asp Val Gly Val Phe His
225                 230                 235                 240 
Ser Phe Thr Ser Pro Tyr Lys Leu Pro Leu Trp Ser Met Cys Ser Gly
                245                 250                 255     
Ala Asp Ser Phe Thr Gln Glu Cys Met Glu Glu Lys Ser Phe Phe Cys
            260                 265                 270         
Arg Val Ser Val Arg Lys Ser His Glu Asn Glu Ile Arg Tyr His Pro
        275                 280                 285             
Phe Arg Met Thr Pro Tyr Leu Val Lys Val Arg Asp Gln Gln Gly Ala
    290                 295                 300                 
Glu Ser Gln Leu Cys Cys Leu Leu Leu Ala Glu Arg Val His Ser Gly
305                 310                 315                 320 
Tyr Glu Ala Pro Arg Ile Pro Pro Glu Lys Arg Ile Phe Thr Thr Thr
                325                 330                 335     
His Thr Pro Asn Cys Leu Phe Gln Asp Val Asp Glu Ser Pro Ala Val
            340                 345                 350         
Arg Arg Ala Ala Phe Arg Leu Phe Ser His Ser Val Ser Arg Pro Glu
        355                 360                 365             
Arg Arg Val His His Val Gly His Gln Leu Val Gln Leu His Gln Pro
    370                 375                 380                 
Met Glu Gln Glu Asn Leu Leu His His Trp Glu Ala Gln Ser Gln Gly
385                 390                 395                 400 
Gly Pro Phe Glu
                


<210> 8047
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 8047
Met Asn Gly Tyr Ala Glu Phe Pro Pro Ser Pro Ser Asn Pro Thr Lys
 1               5                  10                  15      
Glu Pro Val Glu Pro Gln Pro Ser Gln Val Pro Leu Gln Glu Asp Val
            20                  25                  30          
Asp Met Ser Ser Gly Ser Ser Gly His Glu Thr Asn Glu Asn Cys Ser
        35                  40                  45              
Thr Gly Arg Asp Ser Gln Gly Ser Asp Cys Asp Asp Ser Gly Lys Glu
    50                  55                  60                  
Leu Gly Met Leu Val Glu Pro Pro Asp Ala Arg Gln Ser Pro Asp Thr
65                  70                  75                  80  
Phe Ser Leu Met Met Ala Lys Ser Glu His Asn Pro Ser Thr Ser Gly
                85                  90                  95      
Cys Ser Ser Asp Gln Ser Ser Lys Val Asp Thr His Lys Glu Leu Ile
            100                 105                 110         
Lys Thr Leu Lys Glu Leu Lys Val His Leu Pro Ala Asp Lys Lys Ala
        115                 120                 125             
Lys Gly Lys Ala Ser Thr Leu Ala Thr Leu Lys Tyr Ala Leu Arg Ser
    130                 135                 140                 
Val Lys Gln Val Lys Ala Asn Glu Glu Tyr Tyr Gln Leu Leu Met Ser
145                 150                 155                 160 
Ser Glu Gly His Pro Cys Gly Ala Asp Val Pro Ser Tyr Thr Val Glu
                165                 170                 175     
Glu Met Glu Ser Val Thr Ser Glu His Ile Val Lys Asn Ala Asp Met
            180                 185                 190         
Phe Ala Val Ala Val Ser Leu Val Ser Gly Lys Ile Leu Tyr Ile Ser
        195                 200                 205             
Asp Gln Val Ala Ser Ile Phe His Cys Lys Arg Asp Ala Phe Ser Asp
    210                 215                 220                 
Ala Lys Phe Val Glu Phe Leu Ala Pro His Asp Val Gly Val Phe His
225                 230                 235                 240 
Ser Phe Thr Ser Pro Tyr Lys Leu Pro Leu Trp Ser Met Cys Ser Gly
                245                 250                 255     
Ala Asp Ser Phe Thr Gln Glu Cys Met Glu Glu Lys Ser Phe Phe Cys
            260                 265                 270         
Arg Val Ser Val Arg Lys Ser His Glu Asn Glu Ile Arg Tyr His Pro
        275                 280                 285             
Phe Arg Met Thr Pro Tyr Leu Val Lys Val Arg Asp Gln Gln Gly Ala
    290                 295                 300                 
Glu Ser Gln Leu Cys Cys Leu Leu Leu Ala Glu Arg Val His Ser Gly
305                 310                 315                 320 
Tyr Glu Ala Pro Arg Ile Pro Pro Glu Lys Arg Ile Phe Thr Thr Thr
                325                 330                 335     
His Thr Pro Asn Cys Leu Phe Gln Asp Val Asp Glu Arg Ala Val Pro
            340                 345                 350         
Leu Leu Gly Tyr Leu Pro Gln Asp Leu Ile Glu Thr Pro Val Leu Val
        355                 360                 365             
Gln Leu His Pro Ser Asp Arg Pro Leu Met Leu Ala Ile His Lys Lys
    370                 375                 380                 
Ile Leu Gln Ser Gly Gly Gln Pro Phe Asp Tyr Ser Pro Ile Arg Phe
385                 390                 395                 400 
Arg Ala Arg Asn Gly Glu Tyr Ile Thr Leu Asp Thr Ser Trp Ser Ser
                405                 410                 415     
Phe Ile Asn Pro Trp Ser Arg Lys Ile Ser Phe Ile Ile Gly Arg His
            420                 425                 430         
Lys Val Arg Val Gly Pro Leu Asn Glu Asp Val Phe Ala Ala His Pro
        435                 440                 445             
Cys Thr Glu Glu Lys Ala Leu His Pro Ser Ile Gln Glu Leu Thr Glu
    450                 455                 460                 
Gln Ile His Arg Leu Leu Leu Gln Pro Val Pro His Ser Gly Ser Ser
465                 470                 475                 480 
Gly Tyr Gly Ser Leu Gly Ser Asn Gly Ser His Glu His Leu Met Ser
                485                 490                 495     
Gln Thr Ser Ser Ser Asp Ser Asn Gly His Glu Asp Ser Arg Arg Arg
            500                 505                 510         
Arg Ala Glu Ile Cys Lys Asn Gly Asn Lys Thr Lys Asn Arg Ser His
        515                 520                 525             
Tyr Ser His Glu Ser Gly Glu Gln Lys Lys Lys Ser Val Thr Glu Met
    530                 535                 540                 
Gln Thr Asn Pro Pro Ala Glu Lys Lys Ala Val Pro Ala Met Glu Lys
545                 550                 555                 560 
Asp Ser Leu Gly Val Ser Phe Pro Glu Glu Leu Ala Cys Lys Asn Gln
                565                 570                 575     
Pro Thr Cys Ser Tyr Gln Gln Ile Ser Cys Leu Asp Ser Val Ile Arg
            580                 585                 590         
Tyr Leu Glu Ser Cys Asn Glu Ala Ala Thr Leu Lys Arg Lys Cys Glu
        595                 600                 605             
Phe Pro Ala Asn Val Pro Ala Leu Arg Ser Ser Asp Lys Arg Lys Ala
    610                 615                 620                 
Thr Val Ser Pro Gly Pro His Ala Gly Glu Ala Glu Pro Pro Ser Arg
625                 630                 635                 640 
Val Asn Ser Arg Thr Gly Val Gly Thr His Leu Thr Ser Leu Ala Leu
                645                 650                 655     
Pro Gly Lys Ala Glu Ser Val Ala Ser Leu Thr Ser Gln Cys Ser Tyr
            660                 665                 670         
Ser Ser Thr Ile Val His Val Gly Asp Lys Lys Pro Gln Pro Glu Leu
        675                 680                 685             
Glu Met Val Glu Asp Ala Ala Ser Gly Pro Glu Ser Leu Asp Cys Leu
    690                 695                 700                 
Ala Gly Pro Ala Leu Ala Cys Gly Leu Ser Gln Glu Lys Glu Pro Phe
705                 710                 715                 720 
Lys Lys Leu Gly Leu Thr Lys Glu Val Leu Ala Ala His Thr Gln Lys
                725                 730                 735     
Glu Glu Gln Ser Phe Leu Gln Lys Phe Lys Glu Ile Arg Lys Leu Ser
            740                 745                 750         
Ile Phe Gln Ser His Cys His Tyr Tyr Leu Gln Glu Arg Ser Lys Gly
        755                 760                 765             
Gln Pro Ser Glu Arg Thr Ala Pro Gly Leu Arg Asn Thr Ser Gly Ile
    770                 775                 780                 
Asp Ser Pro Trp Lys Lys Thr Gly Lys Asn Arg Lys Leu Lys Ser Lys
785                 790                 795                 800 
Arg Val Lys Pro Arg Asp Ser Ser Glu Ser Thr Gly Ser Gly Gly Pro
                805                 810                 815     
Val Ser Ala Arg Pro Pro Leu Val Gly Leu Asn Ala Thr Ala Trp Ser
            820                 825                 830         
Pro Ser Asp Thr Ser Gln Ser Ser Cys Pro Ala Val Pro Phe Pro Ala
        835                 840                 845             
Pro Val Pro Ala Ala Tyr Ser Leu Pro Val Phe Pro Ala Pro Gly Thr
    850                 855                 860                 
Val Ala Ala Pro Pro Ala Pro Pro His Ala Ser Phe Thr Val Pro Ala
865                 870                 875                 880 
Val Pro Val Asp Leu Gln His Gln Phe Ala Val Gln Pro Pro Pro Phe
                885                 890                 895     
Pro Ala Pro Leu Ala Pro Val Met Ala Phe Met Leu Pro Ser Tyr Ser
            900                 905                 910         
Phe Pro Ser Gly Thr Pro Asn Leu Pro Gln Ala Phe Phe Pro Ser Gln
        915                 920                 925             
Pro Gln Phe Pro Ser His Pro Thr Leu Thr Ser Glu Met Ala Ser Ala
    930                 935                 940                 
Ser Gln Pro Glu Phe Pro Ser Arg Thr Ser Ile Pro Arg Gln Pro Cys
945                 950                 955                 960 
Ala Cys Pro Ala Thr Arg Ala Thr Pro Pro Ser Ala Met Gly Arg Ala
                965                 970                 975     
Ser Pro Pro Leu Phe Gln Ser Arg Ser Ser Ser Pro Leu Gln Leu Asn
            980                 985                 990         
Leu Leu Gln Leu Glu Glu Ala Pro Glu Gly Gly Thr Gly Ala Met Gly
        995                 1000                1005            
Thr Thr Gly Ala Thr Glu Thr Ala Ala Val Gly Ala Asp Cys Lys Pro
    1010                1015                1020                
Gly Thr Ser Arg Asp Gln Gln Pro Lys Ala Pro Leu Thr Arg Asp Glu
1025                1030                1035                1040
Pro Ser Asp Thr Gln Asn Ser Asp Ala Leu Ser Thr Ser Ser Gly Leu
                1045                1050                1055    
Leu Asn Leu Leu Leu Asn Glu Asp Leu Cys Ser Ala Ser Gly Ser Ala
            1060                1065                1070        
Ala Ser Glu Ser Leu Gly Ser Gly Ser Leu Gly Cys Asp Ala Ser Pro
        1075                1080                1085            
Ser Gly Ala Gly Ser Ser Asp Thr Ser His Thr Ser Lys Tyr Phe Gly
    1090                1095                1100                
Ser Ile Asp Ser Ser Glu Asn Asn His Lys Ala Lys Met Asn Thr Gly
1105                1110                1115                1120
Met Glu Glu Ser Glu His Phe Ile Lys Cys Val Leu Gln Asp Pro Ile
                1125                1130                1135    
Trp Leu Leu Met Ala Asp Ala Asp Ser Ser Val Met Met Thr Tyr Gln
            1140                1145                1150        
Leu Pro Ser Arg Asn Leu Glu Ala Val Leu Lys Glu Asp Arg Glu Lys
        1155                1160                1165            
Leu Lys Leu Leu Gln Lys Leu Gln Pro Arg Phe Thr Glu Ser Gln Lys
    1170                1175                1180                
Gln Glu Leu Arg Glu Val His Gln Trp Met Gln Thr Gly Gly Leu Pro
1185                1190                1195                1200
Ala Ala Ile Asp Val Ala Glu Cys Val Tyr Cys Glu Asn Lys Glu Lys
                1205                1210                1215    
Gly Asn Ile Cys Ile Pro Tyr Glu Glu Asp Ile Pro Ser Leu Gly Leu
            1220                1225                1230        
Ser Glu Val Ser Asp Thr Lys Glu Asp Glu Asn Gly Ser Pro Leu Asn
        1235                1240                1245            
His Arg Ile Glu Glu Gln Thr
    1250                1255


<210> 8048
<211> 605
<212> PRT
<213> Homo sapiens

<400> 8048
Met Val Glu Gly Pro Gly Cys Thr Leu Asn Gly Glu Lys Ile Arg Ala
 1               5                  10                  15      
Arg Val Leu Pro Gly Gln Ala Val Thr Gly Val Arg Gly Ser Ala Leu
            20                  25                  30          
Arg Ser Leu Gln Gly Arg Ala Leu Arg Leu Ala Ala Ser Thr Val Val
        35                  40                  45              
Val Ser Pro Gln Ala Ala Ala Leu Asn Asn Asp Ser Ser Gln Asn Val
    50                  55                  60                  
Leu Ser Leu Phe Asn Gly Tyr Val Tyr Ser Gly Val Glu Thr Leu Gly
65                  70                  75                  80  
Lys Glu Leu Phe Met Tyr Phe Gly Pro Lys Ala Leu Arg Ile His Phe
                85                  90                  95      
Gly Met Lys Gly Phe Ile Met Ile Asn Pro Leu Glu Tyr Lys Tyr Lys
            100                 105                 110         
Asn Gly Ala Ser Pro Val Leu Glu Val Gln Leu Thr Lys Asp Leu Ile
        115                 120                 125             
Cys Phe Phe Asp Ser Ser Val Glu Leu Arg Asn Ser Met Glu Ser Gln
    130                 135                 140                 
Gln Arg Ile Arg Met Met Lys Glu Leu Asp Val Cys Ser Pro Glu Phe
145                 150                 155                 160 
Ser Phe Leu Arg Ala Glu Ser Glu Val Lys Lys Gln Lys Gly Arg Met
                165                 170                 175     
Leu Gly Asp Val Leu Met Asp Gln Asn Val Leu Pro Gly Val Gly Asn
            180                 185                 190         
Ile Ile Lys Asn Glu Ala Leu Phe Asp Ser Gly Leu His Pro Ala Val
        195                 200                 205             
Lys Val Cys Gln Leu Thr Asp Glu Gln Ile His His Leu Met Lys Met
    210                 215                 220                 
Ile Arg Asp Phe Ser Ile Leu Phe Tyr Arg Cys Arg Lys Ala Gly Leu
225                 230                 235                 240 
Ala Leu Ser Lys His Tyr Lys Val Tyr Lys Arg Pro Asn Cys Gly Gln
                245                 250                 255     
Cys His Cys Arg Ile Thr Val Cys Arg Phe Gly Asp Asn Asn Arg Met
            260                 265                 270         
Thr Tyr Phe Cys Pro His Cys Gln Lys Glu Asn Pro Gln His Val Asp
        275                 280                 285             
Ile Cys Lys Leu Pro Thr Arg Asn Thr Ile Ile Ser Trp Thr Ser Ser
    290                 295                 300                 
Arg Val Asp His Val Met Asp Ser Val Ala Arg Lys Ser Glu Glu His
305                 310                 315                 320 
Trp Thr Cys Val Val Cys Thr Leu Ile Asn Lys Pro Ser Ser Lys Ala
                325                 330                 335     
Cys Asp Ala Cys Leu Thr Ser Arg Pro Ile Asp Ser Val Leu Lys Ser
            340                 345                 350         
Glu Glu Asn Ser Thr Val Phe Ser His Leu Met Lys Tyr Pro Cys Asn
        355                 360                 365             
Thr Phe Gly Lys Pro His Thr Glu Val Lys Ile Asn Arg Lys Thr Ala
    370                 375                 380                 
Phe Gly Thr Thr Thr Leu Val Leu Thr Asp Phe Ser Asn Lys Ser Ser
385                 390                 395                 400 
Thr Leu Glu Arg Lys Thr Lys Gln Asn Gln Ile Leu Asp Glu Glu Phe
                405                 410                 415     
Gln Asn Ser Pro Pro Ala Ser Val Cys Leu Asn Asp Ile Gln His Pro
            420                 425                 430         
Ser Lys Lys Thr Thr Asn Asp Ile Thr Gln Leu Ser Ser Lys Val Asn
        435                 440                 445             
Ile Ser Pro Thr Ile Ser Ser Glu Ser Lys Leu Phe Ser Pro Ala His
    450                 455                 460                 
Lys Lys Pro Lys Thr Ala His Tyr Ser Ser Pro Glu Leu Lys Ser Cys
465                 470                 475                 480 
Asn Pro Gly Tyr Ser Asn Ser Glu Leu Gln Ile Asn Met Thr Asp Gly
                485                 490                 495     
Pro Arg Thr Leu Asn Pro Asp Ser Pro Arg Cys Ser Lys His Asn Arg
            500                 505                 510         
Leu Cys Ile Leu Arg Val Val Arg Lys Asp Gly Glu Asn Lys Gly Arg
        515                 520                 525             
Gln Phe Tyr Ala Cys Pro Leu Pro Arg Glu Ala Gln Cys Gly Phe Phe
    530                 535                 540                 
Glu Trp Ala Asp Leu Ser Phe Pro Phe Cys Asn His Gly Lys Arg Ser
545                 550                 555                 560 
Thr Met Lys Thr Val Leu Lys Ile Gly Pro Asn Asn Gly Lys Asn Phe
                565                 570                 575     
Phe Val Cys Pro Leu Gly Lys Glu Lys Gln Cys Asn Phe Phe Gln Trp
            580                 585                 590         
Ala Glu Asn Gly Pro Gly Ile Lys Ile Ile Pro Gly Cys
        595                 600                 605 


<210> 8049
<211> 1227
<212> PRT
<213> Homo sapiens

<400> 8049
Asn Ile Arg Val Ile Gly Glu Arg Tyr His Leu Ser Tyr Lys Ile Val
 1               5                  10                  15      
Arg Thr Asp Ser Arg Leu Val Arg Ser Ile Leu Thr Ala His Gly Phe
            20                  25                  30          
His Glu Val His Pro Ser Ser Thr Asp Tyr Asn Leu Met Trp Thr Gly
        35                  40                  45              
Ser His Leu Lys Pro Phe Leu Leu Arg Thr Leu Ser Glu Ala Gln Lys
    50                  55                  60                  
Val Asn His Phe Pro Arg Ser Tyr Glu Leu Thr Arg Lys Asp Arg Leu
65                  70                  75                  80  
Tyr Lys Asn Ile Ile Arg Met Gln His Thr His Gly Phe Lys Ala Phe
                85                  90                  95      
His Ile Leu Pro Gln Thr Phe Leu Leu Pro Ala Glu Tyr Ala Glu Phe
            100                 105                 110         
Cys Asn Ser Tyr Ser Lys Asp Arg Gly Pro Trp Ile Val Lys Pro Val
        115                 120                 125             
Ala Ser Ser Arg Gly Arg Gly Val Tyr Leu Ile Asn Asn Pro Asn Gln
    130                 135                 140                 
Ile Ser Leu Glu Glu Asn Ile Leu Val Ser Arg Tyr Ile Asn Asn Pro
145                 150                 155                 160 
Leu Leu Ile Asp Asp Phe Lys Phe Asp Val Arg Leu Tyr Val Leu Val
                165                 170                 175     
Thr Ser Tyr Asp Pro Leu Val Ile Tyr Leu Tyr Glu Glu Gly Leu Ala
            180                 185                 190         
Arg Phe Ala Thr Val Arg Tyr Asp Gln Gly Ala Lys Asn Ile Arg Asn
        195                 200                 205             
Gln Phe Met His Leu Thr Asn Tyr Ser Val Asn Lys Lys Ser Gly Asp
    210                 215                 220                 
Tyr Val Ser Cys Asp Asp Pro Glu Val Glu Asp Tyr Gly Asn Lys Trp
225                 230                 235                 240 
Ser Met Ser Ala Met Leu Arg Tyr Leu Lys Gln Glu Gly Arg Asp Thr
                245                 250                 255     
Thr Ala Leu Met Ala His Val Glu Asp Leu Ile Ile Lys Thr Ile Ile
            260                 265                 270         
Ser Ala Glu Leu Ala Ile Ala Thr Ala Cys Lys Thr Phe Val Pro His
        275                 280                 285             
Arg Ser Ser Cys Phe Glu Leu Tyr Gly Phe Asp Val Leu Ile Asp Ser
    290                 295                 300                 
Thr Leu Lys Pro Trp Leu Leu Glu Val Asn Leu Ser Pro Ser Leu Ala
305                 310                 315                 320 
Cys Asp Ala Pro Leu Asp Leu Lys Ile Lys Ala Ser Met Ile Ser Asp
                325                 330                 335     
Met Phe Thr Val Val Gly Phe Val Cys Gln Asp Pro Ala Gln Arg Ala
            340                 345                 350         
Ser Thr Arg Pro Ile Tyr Pro Thr Phe Glu Ser Ser Arg Arg Asn Pro
        355                 360                 365             
Phe Gln Lys Pro Gln Arg Cys Arg Pro Leu Ser Ala Ser Asp Ala Glu
    370                 375                 380                 
Met Lys Asn Leu Val Gly Ser Ala Arg Glu Lys Gly Pro Gly Lys Leu
385                 390                 395                 400 
Gly Gly Ser Val Leu Gly Leu Ser Met Glu Glu Ile Lys Val Leu Arg
                405                 410                 415     
Arg Val Lys Glu Glu Asn Asp Arg Arg Gly Gly Phe Ile Arg Ile Phe
            420                 425                 430         
Pro Thr Ser Glu Thr Trp Glu Ile Tyr Gly Ser Tyr Leu Glu His Lys
        435                 440                 445             
Thr Ser Met Asn Tyr Met Leu Ala Thr Arg Leu Phe Gln Asp Arg Met
    450                 455                 460                 
Thr Ala Asp Gly Ala Pro Glu Leu Lys Ile Glu Ser Leu Asn Ser Lys
465                 470                 475                 480 
Ala Lys Leu His Ala Ala Leu Tyr Glu Arg Lys Leu Leu Ser Leu Glu
                485                 490                 495     
Val Arg Lys Arg Arg Arg Arg Ser Ser Arg Leu Arg Ala Met Arg Pro
            500                 505                 510         
Lys Tyr Pro Val Ile Thr Gln Pro Ala Glu Met Asn Val Lys Thr Glu
        515                 520                 525             
Thr Glu Ser Glu Glu Glu Glu Glu Val Ala Leu Asp Asn Glu Asp Glu
    530                 535                 540                 
Glu Gln Glu Ala Ser Gln Glu Glu Ser Ala Gly Phe Leu Arg Glu Asn
545                 550                 555                 560 
Gln Ala Lys Tyr Thr Pro Ser Leu Thr Ala Leu Val Glu Asn Thr Pro
                565                 570                 575     
Lys Glu Asn Ser Met Lys Val Arg Glu Trp Asn Asn Lys Gly Gly His
            580                 585                 590         
Cys Cys Lys Leu Glu Thr Gln Glu Leu Glu Pro Lys Phe Asn Leu Met
        595                 600                 605             
Gln Ile Leu Gln Asp Asn Gly Asn Leu Ser Lys Met Gln Ala Arg Ile
    610                 615                 620                 
Ala Phe Ser Ala Tyr Leu Gln His Val Gln Ile Arg Leu Met Lys Asp
625                 630                 635                 640 
Ser Gly Gly Gln Thr Phe Ser Ala Ser Trp Ala Ala Lys Glu Asp Glu
                645                 650                 655     
Gln Met Glu Leu Val Val Arg Phe Leu Lys Arg Ala Ser Asn Asn Leu
            660                 665                 670         
Gln His Ser Leu Arg Met Val Leu Pro Ser Arg Arg Leu Ala Leu Leu
        675                 680                 685             
Glu Arg Arg Arg Ile Leu Ala His Gln Leu Gly Asp Phe Ile Ile Val
    690                 695                 700                 
Tyr Asn Lys Glu Thr Glu Gln Met Ala Glu Lys Lys Ser Lys Lys Lys
705                 710                 715                 720 
Val Glu Glu Glu Glu Glu Asp Gly Val Asn Met Glu Asn Phe Gln Glu
                725                 730                 735     
Phe Ile Arg Gln Ala Ser Glu Ala Glu Leu Glu Glu Val Leu Thr Phe
            740                 745                 750         
Tyr Thr Gln Lys Asn Lys Ser Ala Ser Val Phe Leu Gly Thr His Ser
        755                 760                 765             
Lys Ile Ser Lys Asn Asn Asn Asn Tyr Ser Asp Ser Gly Ala Lys Gly
    770                 775                 780                 
Asp His Pro Glu Thr Ile Met Glu Glu Val Lys Ile Lys Pro Pro Lys
785                 790                 795                 800 
Gln Gln Gln Thr Thr Glu Ile His Ser Asp Lys Leu Ser Arg Phe Thr
                805                 810                 815     
Thr Ser Ala Glu Lys Glu Ala Lys Leu Val Tyr Ser Asn Ser Ser Ser
            820                 825                 830         
Gly Pro Thr Ala Thr Leu Gln Lys Ile Pro Asn Thr His Leu Ser Ser
        835                 840                 845             
Val Thr Thr Ser Asp Leu Ser Pro Gly Pro Cys His His Ser Ser Leu
    850                 855                 860                 
Ser Gln Ile Pro Ser Ala Ile Pro Ser Met Pro His Gln Pro Thr Ile
865                 870                 875                 880 
Leu Leu Asn Thr Val Ser Ala Ser Ala Ser Pro Cys Leu His Pro Gly
                885                 890                 895     
Ala Gln Asn Ile Pro Ser Pro Thr Gly Leu Pro Arg Cys Arg Ser Gly
            900                 905                 910         
Ser His Thr Ile Gly Pro Phe Ser Ser Phe Gln Ser Ala Ala His Ile
        915                 920                 925             
Tyr Ser Gln Lys Leu Ser Arg Pro Ser Ser Ala Lys Ala Gly Ser Cys
    930                 935                 940                 
Tyr Leu Asn Lys His His Ser Gly Ile Ala Lys Thr Gln Lys Glu Gly
945                 950                 955                 960 
Glu Asp Ala Ser Leu Tyr Ser Lys Arg Tyr Asn Gln Ser Met Val Thr
                965                 970                 975     
Ala Glu Leu Gln Arg Leu Ala Glu Lys Gln Ala Ala Arg Gln Tyr Ser
            980                 985                 990         
Pro Ser Ser His Ile Asn Leu Leu Thr Gln Gln Val Thr Asn Leu Asn
        995                 1000                1005            
Leu Ala Thr Gly Ile Ile Asn Arg Ser Ser Ala Ser Ala Pro Pro Thr
    1010                1015                1020                
Leu Arg Pro Ile Ile Ser Pro Ser Gly Pro Thr Trp Ser Thr Gln Ser
1025                1030                1035                1040
Asp Pro Gln Ala Pro Glu Asn His Ser Ser Ser Pro Gly Ser Arg Ser
                1045                1050                1055    
Leu Gln Thr Gly Gly Phe Ala Trp Glu Gly Glu Val Glu Asn Asn Val
            1060                1065                1070        
Tyr Ser Gln Ala Thr Gly Val Val Pro Gln His Lys Tyr His Pro Thr
        1075                1080                1085            
Ala Gly Ser Tyr Gln Leu Gln Phe Ala Leu Gln Gln Leu Glu Gln Gln
    1090                1095                1100                
Lys Leu Gln Ser Arg Gln Leu Leu Asp Gln Ser Arg Ala Arg His Gln
1105                1110                1115                1120
Ala Ile Phe Gly Ser Gln Thr Leu Pro Asn Ser Asn Leu Trp Thr Met
                1125                1130                1135    
Asn Asn Gly Ala Gly Cys Arg Ile Ser Ser Ala Thr Ala Ser Gly Gln
            1140                1145                1150        
Lys Pro Thr Thr Leu Pro Gln Lys Val Val Pro Pro Pro Ser Ser Cys
        1155                1160                1165            
Ala Ser Leu Val Pro Lys Pro Pro Pro Asn His Glu Gln Val Leu Arg
    1170                1175                1180                
Arg Ala Thr Ser Gln Lys Ala Ser Lys Gly Ser Ser Ala Glu Gly Gln
1185                1190                1195                1200
Leu Asn Gly Leu Gln Ser Ser Leu Asn Pro Ala Ala Phe Val Pro Ile
                1205                1210                1215    
Thr Ser Ser Thr Asp Pro Ala His Thr Lys Ile
            1220                1225        


<210> 8050
<211> 817
<212> PRT
<213> Homo sapiens

<400> 8050
Met Glu Glu Ile Lys Val Leu Arg Arg Val Lys Glu Glu Asn Asp Arg
 1               5                  10                  15      
Arg Gly Gly Phe Ile Arg Ile Phe Pro Thr Ser Glu Thr Trp Glu Ile
            20                  25                  30          
Tyr Gly Ser Tyr Leu Glu His Lys Thr Ser Met Asn Tyr Met Leu Ala
        35                  40                  45              
Thr Arg Leu Phe Gln Asp Arg Gly Asn Pro Arg Arg Ser Leu Leu Thr
    50                  55                  60                  
Gly Arg Thr Arg Met Thr Ala Asp Gly Ala Pro Glu Leu Lys Ile Glu
65                  70                  75                  80  
Ser Leu Asn Ser Lys Ala Lys Leu His Ala Ala Leu Tyr Glu Arg Lys
                85                  90                  95      
Leu Leu Ser Leu Glu Val Arg Lys Arg Arg Arg Arg Ser Ser Arg Leu
            100                 105                 110         
Arg Ala Met Arg Pro Lys Tyr Pro Val Ile Thr Gln Pro Ala Glu Met
        115                 120                 125             
Asn Val Lys Thr Glu Thr Glu Ser Glu Glu Glu Glu Glu Val Ala Leu
    130                 135                 140                 
Asp Asn Glu Asp Glu Glu Gln Glu Ala Ser Gln Glu Glu Ser Ala Gly
145                 150                 155                 160 
Phe Leu Arg Glu Asn Gln Ala Lys Tyr Thr Pro Ser Leu Thr Ala Leu
                165                 170                 175     
Val Glu Asn Thr Pro Lys Glu Asn Ser Met Lys Val Arg Glu Trp Asn
            180                 185                 190         
Asn Lys Gly Gly His Cys Cys Lys Leu Glu Thr Gln Glu Leu Glu Pro
        195                 200                 205             
Lys Phe Asn Leu Met Gln Ile Leu Gln Asp Asn Gly Asn Leu Ser Lys
    210                 215                 220                 
Met Gln Ala Arg Ile Ala Phe Ser Ala Tyr Leu Gln His Val Gln Ile
225                 230                 235                 240 
Arg Leu Met Lys Asp Ser Gly Gly Gln Thr Phe Ser Ala Ser Trp Ala
                245                 250                 255     
Ala Lys Glu Asp Glu Gln Met Glu Leu Val Val Arg Phe Leu Lys Arg
            260                 265                 270         
Ala Ser Asn Asn Leu Gln His Ser Leu Arg Met Val Leu Pro Ser Arg
        275                 280                 285             
Arg Leu Ala Leu Leu Glu Arg Arg Arg Ile Leu Ala His Gln Leu Gly
    290                 295                 300                 
Asp Phe Ile Ile Val Tyr Asn Lys Glu Thr Glu Gln Met Ala Glu Lys
305                 310                 315                 320 
Lys Ser Lys Lys Lys Val Glu Glu Glu Glu Glu Asp Gly Val Asn Met
                325                 330                 335     
Glu Asn Phe Gln Glu Phe Ile Arg Gln Ala Ser Glu Ala Glu Leu Glu
            340                 345                 350         
Glu Val Leu Thr Phe Tyr Thr Gln Lys Asn Lys Ser Ala Ser Val Phe
        355                 360                 365             
Leu Gly Thr His Ser Lys Ile Ser Lys Asn Asn Asn Asn Tyr Ser Asp
    370                 375                 380                 
Ser Gly Ala Lys Gly Asp His Pro Glu Thr Ile Met Glu Glu Val Lys
385                 390                 395                 400 
Ile Lys Pro Pro Lys Gln Gln Gln Thr Thr Glu Ile His Ser Asp Lys
                405                 410                 415     
Leu Ser Arg Phe Thr Thr Ser Ala Glu Lys Glu Ala Lys Leu Val Tyr
            420                 425                 430         
Ser Asn Ser Ser Ser Gly Pro Thr Ala Thr Leu Gln Lys Ile Pro Asn
        435                 440                 445             
Thr His Leu Ser Ser Val Thr Thr Ser Asp Leu Ser Pro Gly Pro Cys
    450                 455                 460                 
His His Ser Ser Leu Ser Gln Ile Pro Ser Ala Ile Pro Ser Met Pro
465                 470                 475                 480 
His Gln Pro Thr Ile Leu Leu Asn Thr Val Ser Ala Ser Ala Ser Pro
                485                 490                 495     
Cys Leu His Pro Gly Ala Gln Asn Ile Pro Ser Pro Thr Gly Leu Pro
            500                 505                 510         
Arg Cys Arg Ser Gly Ser His Thr Ile Gly Pro Phe Ser Ser Phe Gln
        515                 520                 525             
Ser Ala Ala His Ile Tyr Ser Gln Lys Leu Ser Arg Pro Ser Ser Ala
    530                 535                 540                 
Lys Ala Gly Ser Cys Tyr Leu Asn Lys His His Ser Gly Ile Ala Lys
545                 550                 555                 560 
Thr Gln Lys Glu Gly Glu Asp Ala Ser Leu Tyr Ser Lys Arg Tyr Asn
                565                 570                 575     
Gln Ser Met Val Thr Ala Glu Leu Gln Arg Leu Ala Glu Lys Gln Ala
            580                 585                 590         
Ala Arg Gln Tyr Ser Pro Ser Ser His Ile Asn Leu Leu Thr Gln Gln
        595                 600                 605             
Val Thr Asn Leu Asn Leu Ala Thr Gly Ile Ile Asn Arg Ser Ser Ala
    610                 615                 620                 
Ser Ala Pro Pro Thr Leu Arg Pro Ile Ile Ser Pro Ser Gly Pro Thr
625                 630                 635                 640 
Trp Ser Thr Gln Ser Asp Pro Gln Ala Pro Glu Asn His Ser Ser Ser
                645                 650                 655     
Pro Gly Ser Arg Ser Leu Gln Thr Gly Gly Phe Ala Trp Glu Gly Glu
            660                 665                 670         
Val Glu Asn Asn Val Tyr Ser Gln Ala Thr Gly Val Val Pro Gln His
        675                 680                 685             
Lys Tyr His Pro Thr Ala Gly Ser Tyr Gln Leu Gln Phe Ala Leu Gln
    690                 695                 700                 
Gln Leu Glu Gln Gln Lys Leu Gln Ser Arg Gln Leu Leu Asp Gln Ser
705                 710                 715                 720 
Arg Ala Arg His Gln Ala Ile Phe Gly Ser Gln Thr Leu Pro Asn Ser
                725                 730                 735     
Asn Leu Trp Thr Met Asn Asn Gly Ala Gly Cys Arg Ile Ser Ser Ala
            740                 745                 750         
Thr Ala Ser Gly Gln Lys Pro Thr Thr Leu Pro Gln Lys Val Val Pro
        755                 760                 765             
Pro Pro Ser Ser Cys Ala Ser Leu Val Pro Lys Pro Pro Pro Asn His
    770                 775                 780                 
Glu Gln Val Leu Arg Arg Ala Thr Ser Gln Lys Ala Ser Asn Thr Arg
785                 790                 795                 800 
Phe Arg Ser Ser Phe Gln Asn Tyr Leu Trp Tyr Phe Phe Gln Ala Val
                805                 810                 815     
Ser
    


<210> 8051
<211> 106
<212> PRT
<213> Homo sapiens

<400> 8051
Met Lys Leu Ile Ser Pro Arg Asp Phe Val Asp Leu Val Leu Val Lys
 1               5                  10                  15      
Arg Tyr Glu Asp Gly Thr Ile Ser Ser Asn Ala Thr His Val Glu His
            20                  25                  30          
Pro Leu Cys Pro Pro Lys Pro Gly Phe Val Arg Gly Phe Asn His Pro
        35                  40                  45              
Cys Gly Cys Phe Cys Glu Pro Leu Pro Gly Glu Pro Thr Lys Thr Asn
    50                  55                  60                  
Leu Val Thr Phe Phe His Thr Asp Leu Ser Gly Tyr Leu Pro Gln Asn
65                  70                  75                  80  
Val Val Asp Ser Phe Phe Pro Arg Ser Met Thr Arg Phe Tyr Ala Asn
                85                  90                  95      
Leu Gln Lys Ala Val Lys Gln Phe His Glu
            100                 105     


<210> 8052
<211> 213
<212> PRT
<213> Homo sapiens

<400> 8052
Met Asp Pro Ala Leu Ala Ala Gln Met Ser Glu Ala Val Ala Glu Lys
 1               5                  10                  15      
Met Leu Gln Tyr Arg Arg Asp Thr Ala Gly Trp Lys Ile Cys Arg Glu
            20                  25                  30          
Gly Asn Gly Val Ser Val Ser Trp Arg Pro Ser Val Glu Phe Pro Gly
        35                  40                  45              
Asn Leu Tyr Arg Gly Glu Gly Ile Val Tyr Gly Thr Leu Glu Glu Val
    50                  55                  60                  
Trp Asp Cys Val Lys Pro Ala Val Gly Gly Leu Arg Val Lys Trp Asp
65                  70                  75                  80  
Glu Asn Val Thr Gly Phe Glu Ile Ile Gln Ser Ile Thr Asp Thr Leu
                85                  90                  95      
Cys Val Ser Arg Thr Ser Thr Pro Ser Ala Ala Met Lys Leu Ile Ser
            100                 105                 110         
Pro Arg Asp Phe Val Asp Leu Val Leu Val Lys Arg Tyr Glu Asp Gly
        115                 120                 125             
Thr Ile Ser Ser Asn Ala Thr His Val Glu His Pro Leu Cys Pro Pro
    130                 135                 140                 
Lys Pro Gly Phe Val Arg Gly Phe Asn His Pro Cys Gly Cys Phe Cys
145                 150                 155                 160 
Glu Pro Leu Pro Gly Glu Pro Thr Lys Thr Asn Leu Val Thr Phe Phe
                165                 170                 175     
His Thr Asp Leu Ser Gly Tyr Leu Pro Gln Asn Val Val Asp Ser Phe
            180                 185                 190         
Phe Pro Arg Ser Met Thr Arg Phe Tyr Ala Asn Leu Gln Lys Ala Val
        195                 200                 205             
Lys Gln Phe His Glu
    210             


<210> 8053
<211> 902
<212> PRT
<213> Homo sapiens

<400> 8053
Met Phe Pro Ala Leu Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro
 1               5                  10                  15      
Tyr Glu Asp Phe Met Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys
            20                  25                  30          
Ala Gln Arg Gly Ser Leu Pro Asn Ser Ala Thr His Gln His Val Arg
        35                  40                  45              
Lys Asn Asn Pro Gln Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp
    50                  55                  60                  
Asp Leu Ile Pro Asp Thr Leu Gln Lys Glu Lys Leu Leu Trp Pro Ile
65                  70                  75                  80  
Ser Leu Ser Ser Ala Val His Arg Gln Ile Glu Ala Ile Asn Arg Asp
                85                  90                  95      
Phe His Ser Cys Leu Gly Trp Met Gln Trp Arg Gly Leu Ser Ser Leu
            100                 105                 110         
Gln Pro Pro Pro Pro Arg Phe Lys Asp Ser Pro Ala Ser Ala Phe Arg
        115                 120                 125             
Val Ala Gly Ile Thr Asp Ser His Met Leu Ser Leu Pro His Leu Arg
    130                 135                 140                 
Ser Arg Gln Leu Leu Tyr Asp Glu Leu Asp Glu Val Asn Pro Arg Leu
145                 150                 155                 160 
Arg Glu Pro Gln Glu Leu Phe Ser Ile Leu Ser Thr Lys Arg Pro Leu
                165                 170                 175     
Gln Ala Pro Arg Trp Pro Ile Glu Cys Glu Val Ile Lys Glu Asn Ile
            180                 185                 190         
His His Ile Glu Trp Ala Pro Pro Gln Pro Glu Tyr Phe Tyr Gln Pro
        195                 200                 205             
Lys Gly Asn Glu Lys Val Pro Glu Ile Val Gly Glu Lys Lys Gly Thr
    210                 215                 220                 
Val Val Tyr Gln Leu Asp Ser Val Pro Ile Glu Gly Ser Tyr Phe Thr
225                 230                 235                 240 
Ser Ser Arg Val Gly Gly Lys Arg Gly Ile Val Lys Glu Leu Ala Val
                245                 250                 255     
Thr Leu Gln Gly Pro Glu Asp Asn Thr Leu Leu Phe Glu Ser Arg Phe
            260                 265                 270         
Glu Ser Gly Asn Leu Gln Lys Ala Val Arg Val Asp Thr Tyr Glu Tyr
        275                 280                 285             
Glu Leu Thr Leu Arg Thr Asp Leu Tyr Thr Asn Lys His Thr Gln Trp
    290                 295                 300                 
Phe Tyr Phe Arg Val Gln Asn Thr Arg Lys Asp Ala Thr Tyr Arg Phe
305                 310                 315                 320 
Thr Ile Val Asn Leu Leu Lys Pro Lys Ser Leu Tyr Thr Val Gly Met
                325                 330                 335     
Lys Pro Leu Leu Tyr Ser Gln Leu Asp Ala Asn Thr Arg Asn Ile Gly
            340                 345                 350         
Trp Arg Arg Glu Gly Asn Glu Ile Lys Tyr Tyr Lys Asn Asn Thr Asp
        355                 360                 365             
Asp Gly Gln Gln Pro Phe Tyr Cys Leu Thr Trp Thr Ile Gln Phe Pro
    370                 375                 380                 
Tyr Asp Gln Asp Thr Cys Phe Phe Ala His Phe Tyr Pro Tyr Thr Tyr
385                 390                 395                 400 
Thr Asp Leu Gln Cys Tyr Leu Leu Ser Val Ala Asn Asn Pro Ile Gln
                405                 410                 415     
Ser Gln Phe Cys Lys Leu Gln Thr Leu Cys Arg Ser Leu Ala Gly Asn
            420                 425                 430         
Thr Val Tyr Leu Leu Thr Ile Thr Asn Pro Ser Gln Thr Pro Gln Glu
        435                 440                 445             
Ala Ala Ala Lys Lys Ala Val Val Leu Ser Ala Arg Val His Pro Gly
    450                 455                 460                 
Glu Ser Asn Gly Ser Trp Val Met Lys Gly Phe Leu Asp Phe Ile Leu
465                 470                 475                 480 
Ser Asn Ser Pro Asp Ala Gln Leu Leu Arg Asp Ile Phe Val Phe Lys
                485                 490                 495     
Val Leu Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg
            500                 505                 510         
Cys Ser Leu Ala Gly Arg Asp Leu Asn Arg His Tyr Lys Thr Ile Leu
        515                 520                 525             
Lys Glu Ser Phe Pro Cys Ile Trp Tyr Thr Arg Asn Met Ile Lys Arg
    530                 535                 540                 
Leu Leu Glu Glu Arg Glu Val Leu Leu Tyr Cys Asp Phe His Gly His
545                 550                 555                 560 
Ser Arg Lys Asn Asn Ile Phe Leu Tyr Gly Cys Asn Asn Asn Asn Arg
                565                 570                 575     
Lys Tyr Trp Leu His Glu Arg Val Phe Pro Leu Met Leu Cys Lys Asn
            580                 585                 590         
Ala Pro Asp Lys Phe Ser Phe His Ser Cys Asn Phe Lys Val Gln Lys
        595                 600                 605             
Cys Lys Glu Gly Thr Gly Arg Val Val Met Trp Arg Met Gly Ile Leu
    610                 615                 620                 
Asn Ser Tyr Thr Met Glu Ser Thr Phe Gly Gly Ser Thr Leu Gly Asn
625                 630                 635                 640 
Lys Arg Asp Thr His Phe Thr Ile Glu Asp Leu Lys Ser Leu Gly Tyr
                645                 650                 655     
His Val Cys Asp Thr Leu Leu Asp Phe Cys Asp Pro Asp Gln Met Lys
            660                 665                 670         
Phe Thr Gln Cys Leu Ala Glu Leu Lys Glu Leu Leu Arg Gln Glu Ile
        675                 680                 685             
His Lys Lys Phe His Glu Leu Gly Gln Asp Val Asp Leu Glu Gly Ser
    690                 695                 700                 
Trp Ser Asp Ile Ser Leu Ser Asp Ile Glu Ser Ser Thr Ser Gly Ser
705                 710                 715                 720 
Asp Ser Ser Leu Ser Asp Gly Leu Pro Val His Leu Ala Asn Ile Ala
                725                 730                 735     
Asp Glu Leu Thr Gln Lys Lys Lys Met Phe Lys Lys Lys Lys Lys Lys
            740                 745                 750         
Ser Leu Gln Thr Arg Lys Gln Arg Asn Glu Gln Tyr Gln Lys Lys Asn
        755                 760                 765             
Leu Met Gln Lys Leu Lys Leu Thr Glu Asp Thr Ser Glu Lys Ala Gly
    770                 775                 780                 
Phe Ala Ser Thr Leu Gln Lys Gln Pro Thr Phe Phe Lys Asn Ser Glu
785                 790                 795                 800 
Asn Ser Ser Phe Leu Pro Met Lys Asn Glu Asn Pro Arg Leu Asn Glu
                805                 810                 815     
Thr Asn Leu Asn Arg Arg Asp Lys Asp Thr Pro Leu Asp Pro Ser Met
            820                 825                 830         
Ala Thr Leu Ile Leu Pro Lys Asn Lys Gly Arg Met Gln Asn Lys Lys
        835                 840                 845             
Pro Gly Phe Thr Val Ser Cys Ser Pro Lys Arg Thr Ile Asn Ser Ser
    850                 855                 860                 
Gln Glu Pro Ala Pro Gly Met Lys Pro Asn Trp Pro Arg Ser Arg Tyr
865                 870                 875                 880 
Pro Ala Thr Lys Arg Gly Cys Ala Ala Met Ala Ala Tyr Pro Ser Leu
                885                 890                 895     
His Ile Tyr Thr Tyr Pro
            900         


<210> 8054
<211> 285
<212> PRT
<213> Homo sapiens

<400> 8054
Met Trp Arg Met Gly Ile Leu Asn Ser Tyr Thr Met Glu Ser Thr Phe
 1               5                  10                  15      
Gly Gly Ser Thr Leu Gly Asn Lys Arg Asp Thr His Phe Thr Ile Glu
            20                  25                  30          
Asp Leu Lys Ser Leu Gly Tyr His Val Cys Asp Thr Leu Leu Asp Phe
        35                  40                  45              
Cys Asp Pro Asp Gln Ile Lys Phe Thr Gln Cys Leu Ala Glu Leu Lys
    50                  55                  60                  
Glu Leu Leu Arg Gln Glu Ile His Lys Lys Phe His Glu Leu Gly Gln
65                  70                  75                  80  
Asp Val Asp Leu Glu Gly Ser Trp Ser Asp Ile Ser Leu Ser Asp Ile
                85                  90                  95      
Glu Ser Ser Thr Ser Gly Ser Asp Ser Ser Leu Ser Asp Gly Leu Pro
            100                 105                 110         
Val His Leu Ala Asn Ile Ala Asp Glu Leu Thr Gln Lys Lys Lys Met
        115                 120                 125             
Phe Lys Lys Lys Lys Lys Lys Ser Leu Gln Thr Arg Lys Gln Arg Asn
    130                 135                 140                 
Glu Gln Tyr Gln Lys Lys Asn Leu Met Gln Lys Leu Lys Leu Thr Glu
145                 150                 155                 160 
Asp Thr Ser Glu Lys Ala Gly Phe Ala Ser Thr Leu Gln Lys Gln Pro
                165                 170                 175     
Thr Phe Phe Lys Asn Ser Glu Asn Ser Ser Phe Leu Pro Met Lys Asn
            180                 185                 190         
Glu Asn Pro Arg Leu Asn Glu Thr Asn Leu Asn Arg Arg Asp Lys Asp
        195                 200                 205             
Thr Pro Leu Asp Pro Ser Met Ala Thr Leu Ile Leu Pro Lys Asn Lys
    210                 215                 220                 
Gly Arg Met Gln Asn Lys Lys Pro Gly Phe Thr Val Ser Cys Ser Pro
225                 230                 235                 240 
Lys Arg Thr Ile Asn Ser Ser Gln Glu Pro Ala Pro Gly Met Lys Pro
                245                 250                 255     
Asn Trp Pro Arg Ser Arg Tyr Pro Ala Thr Lys Arg Gly Cys Ala Ala
            260                 265                 270         
Met Ala Ala Tyr Pro Ser Leu His Ile Tyr Thr Tyr Pro
        275                 280                 285 


<210> 8055
<211> 1314
<212> PRT
<213> Homo sapiens

<400> 8055
Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Ile Val Glu
 1               5                  10                  15      
Glu Glu Ser Gly Lys Glu Val Leu Gly Ser Ala Pro Ser Gly Ala Arg
            20                  25                  30          
Leu Ser Pro Ser Arg Thr Ser Glu Gly Ser Ala Gly Ser Ala Gly Leu
        35                  40                  45              
Gly Gly Gly Gly Ala Gly Ala Gly Ala Gly Val Gly Ala Gly Gly Gly
    50                  55                  60                  
Gly Gly Ser Gly Ala Ser Ser Gly Gly Gly Ala Gly Gly Leu Gln Pro
65                  70                  75                  80  
Ser Ser Arg Ala Gly Gly Gly Arg Pro Ser Ser Pro Ser Pro Ser Val
                85                  90                  95      
Val Ser Glu Lys Glu Lys Glu Glu Leu Glu Arg Leu Gln Lys Glu Glu
            100                 105                 110         
Glu Glu Arg Lys Lys Arg Leu Gln Leu Tyr Val Phe Val Met Arg Cys
        115                 120                 125             
Ile Ala Tyr Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg
    130                 135                 140                 
Gln Gln Lys Ile Ser Lys Gln Gln Leu Gln Thr Val Lys Asp Arg Phe
145                 150                 155                 160 
Gln Ala Phe Leu Asn Gly Glu Thr Gln Ile Met Ala Asp Glu Ala Phe
                165                 170                 175     
Met Asn Ala Val Gln Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg
            180                 185                 190         
Val Ala Arg Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Ser Arg
        195                 200                 205             
Glu Val Phe Lys Lys His Ile Glu Lys Arg Val Arg Ser Leu Pro Glu
    210                 215                 220                 
Ile Asp Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Met Ala Lys
225                 230                 235                 240 
Phe Asp Ala Ile Tyr Arg Gly Glu Glu Asp Pro Arg Lys Gln Gln Ala
                245                 250                 255     
Arg Met Thr Ala Ser Ala Ala Ser Glu Leu Ile Leu Ser Lys Glu Gln
            260                 265                 270         
Leu Tyr Glu Met Phe Gln Asn Ile Leu Gly Ile Lys Lys Phe Glu His
        275                 280                 285             
Gln Leu Leu Tyr Asn Ala Cys Gln Leu Asp Asn Pro Asp Glu Gln Ala
    290                 295                 300                 
Ala Gln Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Met Ala Asp Gln
305                 310                 315                 320 
Ile Ala Arg Glu Arg Lys Phe Pro Lys Phe Val Ser Lys Glu Met Glu
                325                 330                 335     
Asn Met Tyr Ile Glu Glu Leu Lys Ser Ser Val Asn Leu Leu Met Ala
            340                 345                 350         
Asn Leu Glu Ser Met Pro Val Ser Lys Gly Gly Glu Phe Lys Leu Gln
        355                 360                 365             
Lys Leu Lys Arg Ser His Asn Ala Ser Ile Ile Asp Met Gly Glu Glu
    370                 375                 380                 
Ser Glu Asn Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Ser Leu
385                 390                 395                 400 
Glu Val Val Ile Met Glu Val Gln Gly Leu Lys Ser Leu Ala Pro Asn
                405                 410                 415     
Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly Gly Glu Lys Leu Gln
            420                 425                 430         
Thr Asp Gln Ala Glu Ala Ser Lys Pro Thr Trp Gly Thr Gln Gly Asp
        435                 440                 445             
Phe Ser Thr Thr His Ala Leu Pro Ala Val Lys Val Lys Leu Phe Thr
    450                 455                 460                 
Glu Ser Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val
465                 470                 475                 480 
Ile Leu His Pro Thr Pro Asn Ser Pro Lys Gln Ser Glu Trp His Lys
                485                 490                 495     
Met Thr Val Ser Lys Asn Cys Pro Asp Gln Asp Leu Lys Ile Lys Leu
            500                 505                 510         
Ala Val Arg Met Asp Lys Pro Gln Asn Met Lys His Ser Gly Tyr Leu
        515                 520                 525             
Trp Ala Ile Gly Lys Asn Val Trp Lys Arg Trp Lys Lys Arg Phe Phe
    530                 535                 540                 
Val Leu Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg
545                 550                 555                 560 
Glu Lys Lys Ala Glu Pro Gln Glu Leu Leu Gln Leu Asp Gly Tyr Thr
                565                 570                 575     
Val Asp Tyr Thr Asp Pro Gln Pro Gly Leu Glu Gly Gly Arg Ala Phe
            580                 585                 590         
Phe Asn Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp
        595                 600                 605             
Glu Gln Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly
    610                 615                 620                 
Gln Ser His Lys Pro Val Pro Pro Thr Gln Val Gln Lys Leu Asn Ala
625                 630                 635                 640 
Lys Gly Gly Asn Val Pro Gln Leu Asp Ala Pro Ile Ser Gln Phe Tyr
                645                 650                 655     
Ala Asp Arg Ala Gln Lys His Gly Met Asp Glu Phe Ile Ser Ser Asn
            660                 665                 670         
Pro Cys Asn Phe Asp His Ala Ser Leu Phe Glu Met Val Gln Arg Leu
        675                 680                 685             
Thr Leu Asp His Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe
    690                 695                 700                 
Ser Pro Gly Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Asn Gly
705                 710                 715                 720 
Val Arg Gly Cys His Arg His Leu Cys Tyr Leu Arg Asp Leu Leu Glu
                725                 730                 735     
Arg Ala Glu Asn Gly Ala Met Ile Asp Pro Thr Leu Leu His Tyr Ser
            740                 745                 750         
Phe Ala Phe Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile
        755                 760                 765             
Gly Thr Val Thr Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu
    770                 775                 780                 
Arg Leu Arg Val Leu Leu Glu Asn Gln Ile Thr His Phe Arg Tyr Cys
785                 790                 795                 800 
Phe Pro Phe Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu
                805                 810                 815     
Leu Glu Arg Val Leu Met Lys Asp Ile Val Thr Pro Val Pro Gln Glu
            820                 825                 830         
Glu Val Lys Thr Val Ile Arg Lys Cys Leu Glu Gln Ala Ala Leu Val
        835                 840                 845             
Asn Tyr Ser Arg Leu Ser Glu Tyr Ala Lys Ile Glu Gly Lys Lys Arg
    850                 855                 860                 
Glu Met Tyr Glu His Pro Val Phe Cys Leu Ala Ser Gln Val Met Asp
865                 870                 875                 880 
Leu Thr Ile Gln Asn Val Gly Arg Leu Ile Thr Pro Ala Lys Lys Leu
                885                 890                 895     
Glu Asp Thr Ile Arg Leu Ala Glu Leu Val Ile Glu Val Leu Gln Gln
            900                 905                 910         
Asn Glu Glu His His Ala Glu Ala Phe Ala Trp Trp Ser Asp Leu Met
        915                 920                 925             
Val Glu His Ala Glu Thr Phe Leu Ser Leu Phe Ala Val Asp Met Asp
    930                 935                 940                 
Ala Ala Leu Glu Val Gln Pro Pro Asp Thr Trp Asp Ser Phe Pro Leu
945                 950                 955                 960 
Phe Gln Leu Leu Asn Asp Phe Leu Arg Thr Asp Tyr Asn Leu Cys Asn
                965                 970                 975     
Gly Lys Phe His Lys His Leu Gln Asp Leu Phe Ala Pro Leu Val Val
            980                 985                 990         
Arg Tyr Val Asp Leu Met Glu Ser Ser Ile Ala Gln Ser Ile His Arg
        995                 1000                1005            
Gly Phe Glu Arg Glu Ser Trp Glu Pro Val Asn Asn Gly Ser Gly Thr
    1010                1015                1020                
Ser Glu Asp Leu Phe Trp Lys Leu Asp Ala Leu Gln Thr Phe Ile Arg
1025                1030                1035                1040
Asp Leu His Trp Pro Glu Glu Glu Phe Gly Lys His Leu Glu Gln Arg
                1045                1050                1055    
Leu Lys Leu Met Ala Ser Asp Met Ile Glu Ser Cys Val Lys Arg Thr
            1060                1065                1070        
Arg Ile Ala Phe Glu Val Lys Leu Gln Lys Thr Ser Arg Ser Thr Asp
        1075                1080                1085            
Phe Arg Val Pro Gln Ser Ile Cys Thr Met Phe Asn Val Met Val Asp
    1090                1095                1100                
Ala Lys Ala Gln Ser Thr Lys Leu Cys Ser Met Glu Met Gly Gln Glu
1105                1110                1115                1120
His Gln Tyr His Ser Lys Ile Asp Glu Leu Ile Glu Glu Thr Val Lys
                1125                1130                1135    
Glu Met Ile Thr Leu Leu Val Ala Lys Phe Val Thr Ile Leu Glu Gly
            1140                1145                1150        
Val Leu Ala Lys Leu Ser Arg Tyr Asp Glu Gly Thr Leu Phe Ser Ser
        1155                1160                1165            
Phe Leu Ser Phe Thr Val Lys Ala Ala Ser Lys Tyr Val Asp Val Pro
    1170                1175                1180                
Lys Pro Gly Met Asp Val Ala Asp Ala Tyr Val Thr Phe Val Arg His
1185                1190                1195                1200
Ser Gln Asp Val Leu Arg Asp Lys Val Asn Glu Glu Met Tyr Ile Glu
                1205                1210                1215    
Arg Leu Phe Asp Gln Trp Tyr Asn Ser Ser Met Asn Val Ile Cys Thr
            1220                1225                1230        
Trp Leu Thr Asp Arg Met Asp Leu Gln Leu His Ile Tyr Gln Leu Lys
        1235                1240                1245            
Thr Leu Ile Arg Met Val Lys Lys Thr Tyr Arg Asp Phe Arg Leu Gln
    1250                1255                1260                
Gly Val Leu Asp Ser Thr Leu Asn Ser Lys Thr Tyr Glu Thr Ile Arg
1265                1270                1275                1280
Asn Arg Leu Thr Val Glu Glu Ala Thr Ala Ser Val Ser Glu Gly Gly
                1285                1290                1295    
Gly Leu Gln Gly Ile Ser Met Lys Asp Ser Asp Glu Glu Asp Glu Glu
            1300                1305                1310        
Asp Asp
        


<210> 8056
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 8056
Pro Gly Glu Lys Arg Pro Pro Gly Arg Ala Asp Pro Arg Leu Pro Pro
 1               5                  10                  15      
Ala Pro Pro Thr Phe Cys Thr Pro Ser Arg Gly Leu Gln Arg Pro Arg
            20                  25                  30          
Ser Pro Gly Ala Thr Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser
        35                  40                  45              
Asp Glu Ile Val Glu Glu Glu Ser Gly Lys Glu Val Leu Gly Ser Ala
    50                  55                  60                  
Pro Ser Gly Ala Arg Leu Ser Pro Ser Arg Thr Ser Glu Gly Ser Ala
65                  70                  75                  80  
Gly Ser Ala Gly Leu Gly Gly Gly Gly Ala Gly Ala Gly Ala Gly Val
                85                  90                  95      
Gly Ala Gly Gly Gly Gly Gly Ser Gly Ala Ser Ser Gly Gly Gly Ala
            100                 105                 110         
Gly Gly Leu Gln Pro Ser Ser Arg Ala Gly Gly Gly Arg Pro Ser Ser
        115                 120                 125             
Pro Ser Pro Ser Val Val Ser Glu Lys Glu Lys Glu Glu Leu Glu Arg
    130                 135                 140                 
Leu Gln Lys Glu Glu Glu Glu Arg Lys Lys Arg Leu Gln Leu Tyr Val
145                 150                 155                 160 
Phe Val Met Arg Cys Ile Ala Tyr Pro Phe Asn Ala Lys Gln Pro Thr
                165                 170                 175     
Asp Met Ala Arg Arg Gln Gln Lys Ile Ser Lys Gln Gln Leu Gln Thr
            180                 185                 190         
Val Lys Asp Arg Phe Gln Ala Phe Leu Asn Gly Glu Thr Gln Ile Met
        195                 200                 205             
Ala Asp Glu Ala Phe Met Asn Ala Val Gln Ser Tyr Tyr Glu Val Phe
    210                 215                 220                 
Leu Lys Ser Asp Arg Val Ala Arg Met Val Gln Ser Gly Gly Cys Ser
225                 230                 235                 240 
Ala Asn Asp Ser Arg Glu Val Phe Lys Lys His Ile Glu Lys Arg Val
                245                 250                 255     
Arg Ser Leu Pro Glu Ile Asp Gly Leu Ser Lys Glu Thr Val Leu Ser
            260                 265                 270         
Ser Trp Met Ala Lys Phe Asp Ala Ile Tyr Arg Gly Glu Glu Asp Pro
        275                 280                 285             
Arg Lys Gln Gln Ala Arg Met Thr Ala Ser Ala Ala Ser Glu Leu Ile
    290                 295                 300                 
Leu Ser Lys Glu Gln Leu Tyr Glu Met Phe Gln Asn Ile Leu Gly Ile
305                 310                 315                 320 
Lys Lys Phe Glu His Gln Leu Leu Tyr Asn Ala Cys Gln Leu Asp Asn
                325                 330                 335     
Pro Asp Glu Gln Ala Ala Gln Ile Arg Arg Glu Leu Asp Gly Arg Leu
            340                 345                 350         
Gln Met Ala Asp Gln Ile Ala Arg Glu Arg Lys Phe Pro Lys Phe Val
        355                 360                 365             
Ser Lys Glu Met Glu Asn Met Tyr Ile Glu Glu Leu Lys Ser Ser Val
    370                 375                 380                 
Asn Leu Leu Met Ala Asn Leu Glu Ser Met Pro Val Ser Lys Gly Gly
385                 390                 395                 400 
Glu Phe Lys Leu Gln Lys Leu Lys Arg Ser His Asn Ala Ser Ile Ile
                405                 410                 415     
Asp Met Gly Glu Glu Ser Glu Asn Gln Leu Ser Lys Ser Asp Val Val
            420                 425                 430         
Leu Ser Phe Ser Leu Glu Val Val Ile Met Glu Val Gln Gly Leu Lys
        435                 440                 445             
Ser Leu Ala Pro Asn Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly
    450                 455                 460                 
Gly Glu Lys Leu Gln Thr Asp Gln Ala Glu Ala Ser Lys Pro Thr Trp
465                 470                 475                 480 
Gly Thr Gln Gly Asp Phe Ser Thr Thr His Ala Leu Pro Ala Val Lys
                485                 490                 495     
Val Lys Leu Phe Thr Glu Ser Thr Gly Val Leu Ala Leu Glu Asp Lys
            500                 505                 510         
Glu Leu Gly Arg Val Ile Leu His Pro Thr Pro Asn Ser Pro Lys Gln
        515                 520                 525             
Ser Glu Trp His Lys Met Thr Val Ser Lys Asn Cys Pro Asp Gln Asp
    530                 535                 540                 
Leu Lys Ile Lys Leu Ala Val Arg Met Asp Lys Pro Gln Asn Met Lys
545                 550                 555                 560 
His Ser Gly Tyr Leu Trp Ala Ile Gly Lys Asn Val Trp Lys Arg Trp
                565                 570                 575     
Lys Lys Arg Phe Phe Val Leu Val Gln Val Ser Gln Tyr Thr Phe Ala
            580                 585                 590         
Met Cys Ser Tyr Arg Glu Lys Lys Ala Glu Pro Gln Glu Leu Leu Gln
        595                 600                 605             
Leu Asp Gly Tyr Thr Val Asp Tyr Thr Asp Pro Gln Pro Gly Leu Glu
    610                 615                 620                 
Gly Gly Arg Ala Phe Phe Asn Ala Val Lys Glu Gly Asp Thr Val Ile
625                 630                 635                 640 
Phe Ala Ser Asp Asp Glu Gln Asp Arg Ile Leu Trp Val Gln Ala Met
                645                 650                 655     
Tyr Arg Ala Thr Gly Gln Ser His Lys Pro Val Pro Pro Thr Gln Val
            660                 665                 670         
Gln Lys Leu Asn Ala Lys Gly Gly Asn Val Pro Gln Leu Asp Ala Pro
        675                 680                 685             
Ile Ser Gln Phe Tyr Ala Asp Arg Ala Gln Lys His Gly Met Asp Glu
    690                 695                 700                 
Phe Ile Ser Ser Asn Pro Cys Asn Phe Asp His Ala Ser Leu Phe Glu
705                 710                 715                 720 
Met Val Gln Arg Leu Thr Leu Asp His Arg Leu Asn Asp Ser Tyr Ser
                725                 730                 735     
Cys Leu Gly Trp Phe Ser Pro Gly Gln Val Phe Val Leu Asp Glu Tyr
            740                 745                 750         
Cys Ala Arg Asn Gly Val Arg Gly Cys His Arg His Leu Cys Tyr Leu
        755                 760                 765             
Arg Asp Leu Leu Glu Arg Ala Glu Asn Gly Ala Met Ile Asp Pro Thr
    770                 775                 780                 
Leu Leu His Tyr Ser Phe Ala Phe Cys Ala Ser His Val His Gly Asn
785                 790                 795                 800 
Arg Pro Asp Gly Ile Gly Thr Val Thr Val Glu Glu Lys Glu Arg Phe
                805                 810                 815     
Glu Glu Ile Lys Glu Arg Leu Arg Val Leu Leu Glu Asn Gln Ile Thr
            820                 825                 830         
His Phe Arg Tyr Cys Phe Pro Phe Gly Arg Pro Glu Gly Ala Leu Lys
        835                 840                 845             
Ala Thr Leu Ser Leu Leu Glu Arg Val Leu Met Lys Asp Ile Val Thr
    850                 855                 860                 
Pro Val Pro Gln Glu Glu Val Lys Thr Val Ile Arg Lys Cys Leu Glu
865                 870                 875                 880 
Gln Ala Ala Leu Val Asn Tyr Ser Arg Leu Ser Glu Tyr Ala Lys Ile
                885                 890                 895     
Glu Glu Asn Gln Lys Asp Ala Glu Asn Val Gly Arg Leu Ile Thr Pro
            900                 905                 910         
Ala Lys Lys Leu Glu Asp Thr Ile Arg Leu Ala Glu Leu Val Ile Glu
        915                 920                 925             
Val Leu Gln Gln Asn Glu Glu His His Ala Glu Pro His Val Asp Lys
    930                 935                 940                 
Gly Glu Ala Phe Ala Trp Trp Ser Asp Leu Met Val Glu His Ala Glu
945                 950                 955                 960 
Thr Phe Leu Ser Leu Phe Ala Val Asp Met Asp Ala Ala Leu Glu Val
                965                 970                 975     
Gln Pro Pro Asp Thr Trp Asp Ser Phe Pro Leu Phe Gln Leu Leu Asn
            980                 985                 990         
Asp Phe Leu Arg Thr Asp Tyr Asn Leu Cys Asn Gly Lys Phe His Lys
        995                 1000                1005            
His Leu Gln Asp Leu Phe Ala Pro Leu Val Val Arg Tyr Val Asp Leu
    1010                1015                1020                
Met Glu Ser Ser Ile Ala Gln Ser Ile His Arg Gly Phe Glu Arg Glu
1025                1030                1035                1040
Ser Trp Glu Pro Val Lys Ser Leu Thr Ser Asn Leu Pro Asn Val Asn
                1045                1050                1055    
Leu Pro Asn Val Asn Leu Pro Lys Val Pro Asn Leu Pro Val Asn Ile
            1060                1065                1070        
Pro Leu Gly Ile Pro Gln Met Pro Thr Phe Ser Ala Pro Ser Trp Met
        1075                1080                1085            
Ala Ala Ile Tyr Asp Ala Asp Asn Gly Ser Gly Thr Ser Glu Asp Leu
    1090                1095                1100                
Phe Trp Lys Leu Asp Ala Leu Gln Thr Phe Ile Arg Asp Leu His Trp
1105                1110                1115                1120
Pro Glu Glu Glu Phe Gly Lys His Leu Glu Gln Arg Leu Lys Leu Met
                1125                1130                1135    
Ala Ser Asp Met Ile Glu Ser Cys Val Lys Arg Thr Arg Ile Ala Phe
            1140                1145                1150        
Glu Val Lys Leu Gln Lys Thr Ser Arg Ser Thr Asp Phe Arg Val Pro
        1155                1160                1165            
Gln Ser Ile Cys Thr Met Phe Asn Val Met Val Asp Ala Lys Ala Gln
    1170                1175                1180                
Ser Thr Lys Leu Cys Ser Met Glu Met Gly Gln Glu His Gln Tyr His
1185                1190                1195                1200
Ser Lys Ile Asp Glu Leu Ile Glu Glu Thr Val Lys Glu Met Ile Thr
                1205                1210                1215    
Leu Leu Val Ala Lys Phe Val Thr Ile Leu Glu Gly Val Leu Ala Lys
            1220                1225                1230        
Leu Ser Arg Tyr Asp Glu Gly Thr Leu Phe Ser Ser Phe Leu Ser Phe
        1235                1240                1245            
Thr Val Lys Ala Ala Ser Lys Tyr Val Asp Val Pro Lys Pro Gly Met
    1250                1255                1260                
Asp Val Ala Asp Ala Tyr Val Thr Phe Val Arg His Ser Gln Asp Val
1265                1270                1275                1280
Leu Arg Asp Lys Val Asn Glu Glu Met Tyr Ile Glu Arg Leu Phe Asp
                1285                1290                1295    
Gln Trp Tyr Asn Ser Ser Met Asn Val Ile Cys Thr Trp Leu Thr Asp
            1300                1305                1310        
Arg Met Asp Leu Gln Leu His Ile Tyr Gln Leu Lys Thr Leu Ile Arg
        1315                1320                1325            
Val Val Lys Lys Thr Tyr Arg Asp Phe Arg Leu Gln Gly Val Leu Asp
    1330                1335                1340                
Ser Thr Leu Asn Ser Lys Thr Tyr Glu Thr Ile Arg Asn Arg Leu Thr
1345                1350                1355                1360
Val Glu Glu Ala Thr Ala Ser Val Ser Glu Gly Gly Gly Leu Gln Gly
                1365                1370                1375    
Ile Ser Met Lys Asp Ser Asp Glu Glu Asp Glu Glu Asp Asp
            1380                1385                1390


<210> 8057
<211> 1274
<212> PRT
<213> Homo sapiens

<400> 8057
Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Ile Val Glu
 1               5                  10                  15      
Glu Glu Ser Gly Lys Glu Val Leu Gly Ser Ala Pro Ser Gly Ala Arg
            20                  25                  30          
Leu Ser Pro Ser Arg Thr Ser Glu Gly Ser Ala Gly Ser Ala Gly Leu
        35                  40                  45              
Gly Gly Gly Gly Ala Gly Ala Gly Ala Gly Val Gly Ala Ser Gly Gly
    50                  55                  60                  
Gly Gly Ser Gly Ala Ser Ser Gly Gly Gly Ala Gly Gly Leu Gln Pro
65                  70                  75                  80  
Ser Ser Arg Ala Gly Gly Gly Arg Pro Ser Ser Pro Ser Pro Ser Val
                85                  90                  95      
Val Ser Glu Lys Glu Lys Glu Glu Leu Glu Arg Leu Gln Lys Glu Glu
            100                 105                 110         
Glu Glu Arg Lys Lys Arg Leu Gln Leu Tyr Val Phe Val Met Arg Cys
        115                 120                 125             
Ile Ala Tyr Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg
    130                 135                 140                 
Gln Gln Lys Ile Ser Lys Gln Gln Leu Gln Thr Val Lys Asp Arg Phe
145                 150                 155                 160 
Gln Ala Phe Leu Asn Gly Glu Thr Gln Ile Met Ala Asp Glu Ala Phe
                165                 170                 175     
Met Asn Ala Val Gln Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg
            180                 185                 190         
Val Ala Arg Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Ser Arg
        195                 200                 205             
Glu Val Phe Lys Lys His Ile Glu Lys Arg Val Arg Ser Leu Pro Glu
    210                 215                 220                 
Ile Asp Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Met Ala Lys
225                 230                 235                 240 
Phe Asp Ala Ile Tyr Arg Gly Glu Glu Asp Pro Arg Lys Gln Gln Ala
                245                 250                 255     
Arg Met Thr Ala Ser Ala Ala Ser Glu Leu Ile Leu Ser Lys Glu Gln
            260                 265                 270         
Leu Tyr Glu Met Phe Gln Asn Ile Leu Gly Ile Lys Lys Phe Glu His
        275                 280                 285             
Gln Leu Leu Tyr Asn Ala Cys Gln Leu Asp Asn Pro Asp Glu Gln Ala
    290                 295                 300                 
Ala Gln Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Met Ala Asp Gln
305                 310                 315                 320 
Ile Ala Arg Glu Arg Lys Phe Pro Lys Phe Val Ser Lys Glu Met Glu
                325                 330                 335     
Asn Met Tyr Ile Glu Glu Leu Lys Ser Ser Val Asn Leu Leu Met Ala
            340                 345                 350         
Asn Leu Glu Ser Met Pro Val Ser Lys Gly Gly Glu Phe Lys Leu Gln
        355                 360                 365             
Lys Leu Lys Arg Ser His Asn Ala Ser Ile Ile Asp Met Gly Glu Glu
    370                 375                 380                 
Ser Glu Asn Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Ser Leu
385                 390                 395                 400 
Glu Val Val Ile Met Glu Val Gln Gly Leu Lys Ser Leu Ala Pro Asn
                405                 410                 415     
Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly Gly Glu Lys Leu Gln
            420                 425                 430         
Thr Asp Gln Ala Glu Ala Ser Lys Pro Thr Trp Gly Thr Gln Gly Asp
        435                 440                 445             
Phe Ser Thr Thr His Ala Leu Pro Ala Val Lys Val Lys Leu Phe Thr
    450                 455                 460                 
Glu Ser Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val
465                 470                 475                 480 
Ile Leu His Pro Thr Pro Asn Ser Pro Lys Gln Ser Glu Trp His Lys
                485                 490                 495     
Met Thr Val Ser Lys Asn Cys Pro Asp Gln Asp Leu Lys Ile Lys Leu
            500                 505                 510         
Ala Val Arg Met Asp Lys Pro Gln Asn Met Lys His Ser Gly Tyr Leu
        515                 520                 525             
Trp Ala Ile Gly Lys Asn Val Trp Lys Arg Trp Lys Lys Arg Phe Phe
    530                 535                 540                 
Val Leu Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg
545                 550                 555                 560 
Glu Lys Lys Ala Glu Pro Gln Glu Leu Leu Gln Leu Asp Gly Tyr Thr
                565                 570                 575     
Val Asp Tyr Thr Asp Pro Gln Pro Gly Leu Glu Gly Gly Arg Ala Phe
            580                 585                 590         
Phe Asn Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp
        595                 600                 605             
Glu Gln Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly
    610                 615                 620                 
Gln Ser His Lys Pro Val Pro Pro Thr Gln Val Gln Lys Leu Asn Ala
625                 630                 635                 640 
Lys Gly Gly Asn Val Pro Gln Leu Asp Ala Pro Ile Ser Gln Phe Tyr
                645                 650                 655     
Ala Asp Arg Ala Gln Lys His Gly Met Asp Glu Phe Ile Ser Ser Asn
            660                 665                 670         
Pro Cys Asn Phe Asp His Ala Ser Leu Phe Glu Met Gly Trp Phe Ser
        675                 680                 685             
Pro Gly Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Asn Gly Val
    690                 695                 700                 
Arg Gly Cys His Arg His Leu Cys Tyr Leu Arg Asp Leu Leu Glu Arg
705                 710                 715                 720 
Ala Glu Asn Gly Ala Met Ile Asp Pro Thr Leu Leu His Tyr Ser Phe
                725                 730                 735     
Ala Phe Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile Gly
            740                 745                 750         
Thr Val Thr Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg
        755                 760                 765             
Leu Arg Val Leu Leu Glu Asn Gln Ile Thr His Phe Arg Tyr Cys Phe
    770                 775                 780                 
Pro Phe Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu
785                 790                 795                 800 
Glu Arg Val Leu Met Lys Asp Ile Val Thr Pro Val Pro Gln Glu Glu
                805                 810                 815     
Val Lys Thr Val Ile Arg Lys Cys Leu Glu Gln Ala Ala Leu Val Asn
            820                 825                 830         
Tyr Ser Arg Leu Ser Glu Tyr Ala Lys Ile Glu Glu Asn Val Gly Arg
        835                 840                 845             
Leu Ile Thr Pro Ala Lys Lys Leu Glu Asp Thr Ile Arg Leu Ala Glu
    850                 855                 860                 
Leu Val Ile Glu Val Leu Gln Gln Asn Glu Glu His His Ala Glu Ala
865                 870                 875                 880 
Phe Ala Trp Trp Ser Asp Leu Met Val Glu His Ala Glu Thr Phe Leu
                885                 890                 895     
Ser Leu Phe Ala Val Asp Met Asp Ala Ala Leu Glu Val Gln Pro Pro
            900                 905                 910         
Asp Thr Trp Asp Ser Phe Pro Leu Phe Gln Leu Leu Asn Asp Phe Leu
        915                 920                 925             
Arg Thr Asp Tyr Asn Leu Cys Asn Gly Lys Phe His Lys His Leu Gln
    930                 935                 940                 
Asp Leu Phe Ala Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu Ser
945                 950                 955                 960 
Ser Ile Ala Gln Ser Ile His Arg Gly Phe Glu Arg Glu Ser Trp Glu
                965                 970                 975     
Pro Val Asn Asn Gly Ser Gly Thr Ser Glu Asp Leu Phe Trp Lys Leu
            980                 985                 990         
Asp Ala Leu Gln Thr Phe Ile Arg Asp Leu His Trp Pro Glu Glu Glu
        995                 1000                1005            
Phe Gly Lys His Leu Glu Gln Arg Leu Lys Leu Met Ala Ser Asp Met
    1010                1015                1020                
Ile Glu Ser Cys Val Lys Arg Thr Arg Ile Ala Phe Glu Val Lys Leu
1025                1030                1035                1040
Gln Lys Thr Ser Arg Ser Thr Asp Phe Arg Val Pro Gln Ser Ile Cys
                1045                1050                1055    
Thr Met Phe Asn Val Met Val Asp Ala Lys Ala Gln Ser Thr Lys Leu
            1060                1065                1070        
Cys Ser Met Glu Met Gly Gln Glu His Gln Tyr His Ser Lys Ile Asp
        1075                1080                1085            
Glu Leu Ile Glu Glu Thr Val Lys Glu Met Ile Thr Leu Leu Val Ala
    1090                1095                1100                
Lys Phe Val Thr Ile Leu Glu Gly Val Leu Ala Lys Leu Ser Arg Tyr
1105                1110                1115                1120
Asp Glu Gly Thr Leu Phe Ser Ser Phe Leu Ser Phe Thr Val Lys Ala
                1125                1130                1135    
Ala Ser Lys Tyr Val Asp Val Pro Lys Pro Gly Met Asp Val Ala Asp
            1140                1145                1150        
Ala Tyr Val Thr Phe Val Arg His Ser Gln Asp Val Leu Arg Asp Lys
        1155                1160                1165            
Val Asn Gly Glu Met Tyr Ile Glu Arg Leu Phe Asp Gln Trp Tyr Asn
    1170                1175                1180                
Ser Ser Met Asn Val Ile Cys Thr Trp Leu Thr Asp Arg Met Asp Leu
1185                1190                1195                1200
Gln Leu His Ile Tyr Gln Leu Lys Thr Leu Ile Arg Met Val Lys Lys
                1205                1210                1215    
Thr Tyr Arg Asp Phe Arg Leu Gln Gly Val Leu Asp Ser Thr Phe Asn
            1220                1225                1230        
Ser Lys Thr Tyr Glu Thr Ile Arg Asn Arg Leu Thr Val Glu Glu Ala
        1235                1240                1245            
Thr Ala Ser Val Ser Glu Gly Gly Gly Leu Gln Gly Ile Ser Met Lys
    1250                1255                1260                
Asp Ser Asp Glu Glu Asp Glu Glu Asp Asp
1265                1270                


<210> 8058
<211> 138
<212> PRT
<213> Homo sapiens

<400> 8058
Gln Ile Ala Arg Glu Arg Lys Phe Pro Lys Phe Val Ser Lys Glu Met
 1               5                  10                  15      
Glu Asn Met Tyr Ile Glu Glu Leu Lys Ser Ser Val Asn Leu Leu Met
            20                  25                  30          
Ala Asn Leu Glu Ser Met Pro Val Ser Lys Gly Gly Glu Phe Lys Leu
        35                  40                  45              
Gln Lys Leu Lys Arg Ser His Asn Ala Ser Ile Ile Asp Met Gly Glu
    50                  55                  60                  
Glu Ser Glu Asn Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Ser
65                  70                  75                  80  
Leu Glu Val Val Ile Met Glu Val Gln Gly Leu Lys Ser Leu Ala Pro
                85                  90                  95      
Asn Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly Gly Glu Lys Leu
            100                 105                 110         
Gln Thr Asp Gln Ala Glu Ala Ser Lys Pro Thr Val Ile Arg Arg Asn
        115                 120                 125             
Arg Arg Glu Gln Leu Pro His Ser Ala Ile
    130                 135             


<210> 8059
<211> 634
<212> PRT
<213> Homo sapiens

<400> 8059
Met Glu Ser Pro Thr Lys Glu Ile Glu Glu Phe Glu Ser Asn Ser Leu
 1               5                  10                  15      
Lys Tyr Leu Gln Pro Glu Gln Ile Glu Lys Ile Trp Leu Arg Leu Arg
            20                  25                  30          
Gly Leu Arg Lys Tyr Lys Lys Thr Ser Gln Arg Leu Arg Ser Leu Val
        35                  40                  45              
Lys Gln Leu Glu Arg Gly Glu Ala Ser Val Val Asp Leu Lys Lys Asn
    50                  55                  60                  
Leu Glu Tyr Ala Ala Thr Val Leu Glu Ser Val Tyr Ile Asp Glu Thr
65                  70                  75                  80  
Arg Arg Leu Leu Asp Thr Glu Asp Glu Leu Ser Asp Ile Gln Ser Asp
                85                  90                  95      
Ala Val Pro Ser Glu Val Arg Asp Trp Leu Ala Ser Thr Phe Thr Arg
            100                 105                 110         
Gln Met Gly Met Met Leu Arg Arg Ser Asp Glu Lys Pro Arg Phe Lys
        115                 120                 125             
Ser Ile Val His Ala Val Gln Ala Gly Ile Phe Val Glu Arg Met Tyr
    130                 135                 140                 
Arg Arg Thr Ser Asn Met Val Gly Leu Ser Tyr Pro Pro Ala Val Ile
145                 150                 155                 160 
Glu Ala Leu Lys Asp Val Asp Lys Trp Ser Phe Asp Val Phe Ser Leu
                165                 170                 175     
Asn Glu Ala Ser Gly Asp His Ala Leu Lys Phe Ile Phe Tyr Glu Leu
            180                 185                 190         
Leu Thr Arg Tyr Asp Leu Ile Ser Arg Phe Lys Ile Pro Ile Ser Ala
        195                 200                 205             
Leu Val Ser Phe Val Glu Ala Leu Glu Val Gly Tyr Ser Lys His Lys
    210                 215                 220                 
Asn Pro Tyr His Asn Leu Met His Ala Ala Asp Val Thr Gln Thr Val
225                 230                 235                 240 
His Tyr Leu Leu Tyr Lys Thr Gly Val Ala Asn Trp Leu Thr Glu Leu
                245                 250                 255     
Glu Ile Phe Ala Ile Ile Phe Ser Ala Ala Ile His Asp Tyr Glu His
            260                 265                 270         
Thr Gly Thr Thr Asn Asn Phe His Ile Gln Thr Arg Ser Asp Pro Ala
        275                 280                 285             
Ile Leu Tyr Asn Asp Arg Ser Val Leu Glu Asn His His Leu Ser Ala
    290                 295                 300                 
Ala Tyr Arg Leu Leu Gln Asp Asp Glu Glu Met Asn Ile Leu Ile Asn
305                 310                 315                 320 
Leu Ser Lys Asp Asp Trp Arg Glu Phe Arg Thr Leu Val Ile Glu Met
                325                 330                 335     
Val Met Ala Thr Asp Met Ser Cys His Phe Gln Gln Ile Lys Ala Met
            340                 345                 350         
Lys Thr Ala Leu Gln Gln Pro Glu Ala Ile Glu Lys Pro Lys Ala Leu
        355                 360                 365             
Ser Leu Met Leu His Thr Ala Asp Ile Ser His Pro Ala Lys Ala Trp
    370                 375                 380                 
Asp Leu His His Arg Trp Thr Met Ser Leu Leu Glu Glu Phe Phe Arg
385                 390                 395                 400 
Gln Gly Asp Arg Glu Ala Glu Leu Gly Leu Pro Phe Ser Pro Leu Cys
                405                 410                 415     
Asp Arg Lys Ser Thr Met Val Ala Gln Ser Gln Val Gly Phe Ile Asp
            420                 425                 430         
Phe Ile Val Glu Pro Thr Phe Thr Val Leu Thr Asp Met Thr Glu Lys
        435                 440                 445             
Ile Val Ser Pro Leu Ile Asp Glu Thr Ser Gln Thr Gly Gly Thr Gly
    450                 455                 460                 
Gln Arg Arg Ser Ser Leu Asn Ser Ile Ser Ser Ser Asp Ala Lys Arg
465                 470                 475                 480 
Ser Gly Val Lys Thr Ser Gly Ser Glu Gly Ser Ala Pro Ile Asn Asn
                485                 490                 495     
Ser Val Ile Ser Val Asp Tyr Lys Ser Phe Lys Ala Thr Trp Thr Glu
            500                 505                 510         
Val Val His Ile Asn Arg Glu Arg Trp Arg Ala Lys Val Pro Lys Glu
        515                 520                 525             
Glu Lys Ala Lys Lys Glu Ala Glu Glu Lys Ala Arg Leu Ala Ala Glu
    530                 535                 540                 
Glu Gln Gln Lys Glu Met Glu Ala Lys Ser Gln Ala Glu Glu Gly Ala
545                 550                 555                 560 
Ser Gly Lys Ala Glu Lys Lys Thr Ser Gly Glu Thr Lys Asn Gln Val
                565                 570                 575     
Asn Gly Thr Arg Ala Asn Lys Ser Asp Asn Pro Arg Gly Lys Asn Ser
            580                 585                 590         
Lys Ala Glu Lys Ser Ser Gly Glu Gln Gln Gln Asn Gly Asp Phe Lys
        595                 600                 605             
Asp Gly Lys Asn Lys Thr Asp Lys Lys Asp His Ser Asn Ile Gly Asn
    610                 615                 620                 
Asp Ser Lys Lys Thr Asp Asp Ser Gln Glu
625                 630                 


<210> 8060
<211> 895
<212> PRT
<213> Homo sapiens

<400> 8060
Met Thr Ala Trp Thr Met Gly Ala Arg Gly Leu Asp Lys Arg Gly Ser
 1               5                  10                  15      
Phe Phe Lys Leu Ile Asp Thr Ile Ala Ser Glu Ile Gly Glu Leu Lys
            20                  25                  30          
Gln Glu Met Val Arg Thr Asp Val Asn Leu Glu Asn Gly Leu Glu Pro
        35                  40                  45              
Ala Glu Thr His Ser Met Val Arg His Lys Asp Gly Gly Tyr Ser Glu
    50                  55                  60                  
Glu Glu Asp Val Lys Thr Cys Ala Arg Asp Ser Gly Tyr Asp Ser Leu
65                  70                  75                  80  
Ser Asn Arg Leu Ser Ile Leu Asp Arg Leu Leu His Thr His Pro Ile
                85                  90                  95      
Trp Leu Gln Leu Ser Leu Ser Glu Glu Glu Ala Ala Glu Val Leu Gln
            100                 105                 110         
Ala Gln Pro Pro Gly Ile Phe Leu Val His Lys Ser Thr Lys Met Gln
        115                 120                 125             
Lys Lys Val Leu Ser Leu Arg Leu Pro Cys Glu Phe Gly Ala Pro Leu
    130                 135                 140                 
Lys Glu Phe Ala Ile Lys Glu Ser Thr Tyr Thr Phe Ser Leu Glu Gly
145                 150                 155                 160 
Ser Gly Ile Ser Phe Ala Asp Leu Phe Arg Leu Ile Ala Phe Tyr Cys
                165                 170                 175     
Ile Ser Arg Asp Val Leu Pro Phe Thr Leu Lys Leu Pro Tyr Ala Ile
            180                 185                 190         
Ser Thr Ala Lys Ser Glu Ala Gln Leu Glu Glu Leu Ala Gln Met Gly
        195                 200                 205             
Leu Asn Phe Trp Ser Ser Pro Ala Asp Ser Lys Pro Pro Asn Leu Pro
    210                 215                 220                 
Pro Pro His Arg Pro Leu Ser Ser Asp Gly Val Cys Pro Ala Ser Leu
225                 230                 235                 240 
Arg Gln Leu Cys Leu Ile Asn Gly Val His Ser Ile Lys Thr Arg Thr
                245                 250                 255     
Pro Ser Glu Leu Glu Cys Ser Gln Thr Asn Gly Ala Leu Cys Phe Ile
            260                 265                 270         
Asn Pro Leu Phe Leu Lys Val His Ser Gln Asp Leu Ser Gly Gly Leu
        275                 280                 285             
Lys Arg Pro Ser Thr Arg Thr Pro Asn Ala Asn Gly Thr Glu Arg Thr
    290                 295                 300                 
Arg Ser Pro Pro Pro Arg Pro Pro Pro Pro Ala Ile Asn Ser Leu His
305                 310                 315                 320 
Thr Ser Pro Arg Leu Ala Arg Thr Glu Thr Gln Thr Ser Met Pro Glu
                325                 330                 335     
Thr Val Asn His Asn Lys His Gly Asn Val Ala Leu Pro Gly Thr Lys
            340                 345                 350         
Pro Thr Pro Ile Pro Pro Pro Arg Leu Lys Lys Gln Ala Ser Phe Leu
        355                 360                 365             
Glu Ala Glu Gly Gly Ala Lys Thr Leu Ser Gly Gly Arg Pro Gly Ala
    370                 375                 380                 
Gly Pro Glu Leu Glu Leu Gly Thr Ala Gly Ser Pro Gly Gly Ala Pro
385                 390                 395                 400 
Pro Glu Ala Ala Pro Gly Asp Cys Thr Arg Ala Pro Pro Pro Ser Ser
                405                 410                 415     
Glu Ser Arg Pro Pro Cys His Gly Gly Arg Gln Arg Leu Ser Asp Met
            420                 425                 430         
Ser Ile Ser Thr Ser Ser Ser Asp Ser Leu Glu Phe Asp Arg Ser Met
        435                 440                 445             
Pro Leu Phe Gly Tyr Glu Ala Asp Thr Asn Ser Ser Leu Glu Asp Tyr
    450                 455                 460                 
Glu Gly Glu Ser Asp Gln Glu Thr Met Ala Pro Pro Ile Lys Ser Lys
465                 470                 475                 480 
Lys Lys Arg Ser Ser Ser Phe Val Leu Pro Lys Leu Val Lys Ser Gln
                485                 490                 495     
Leu Gln Lys Val Ser Gly Val Phe Ser Ser Phe Met Thr Pro Glu Lys
            500                 505                 510         
Arg Met Val Arg Arg Ile Ala Glu Leu Ser Arg Asp Lys Cys Thr Tyr
        515                 520                 525             
Phe Gly Cys Leu Val Gln Asp Tyr Val Ser Phe Leu Gln Glu Asn Lys
    530                 535                 540                 
Glu Cys His Val Ser Ser Thr Asp Met Leu Gln Thr Ile Arg Gln Phe
545                 550                 555                 560 
Met Thr Gln Val Lys Asn Tyr Leu Ser Gln Ser Ser Glu Leu Asp Pro
                565                 570                 575     
Pro Ile Glu Ser Leu Ile Pro Glu Asp Gln Ile Asp Val Val Leu Glu
            580                 585                 590         
Lys Ala Met His Lys Cys Ile Leu Lys Pro Leu Lys Gly His Val Glu
        595                 600                 605             
Ala Met Leu Lys Asp Phe His Met Ala Asp Gly Ser Trp Lys Gln Leu
    610                 615                 620                 
Lys Glu Asn Leu Gln Leu Val Arg Gln Arg Asn Pro Gln Glu Leu Gly
625                 630                 635                 640 
Val Phe Ala Pro Thr Pro Asp Phe Val Asp Val Glu Lys Ile Lys Val
                645                 650                 655     
Lys Phe Met Thr Met Gln Lys Met Tyr Ser Pro Glu Lys Lys Val Met
            660                 665                 670         
Leu Leu Leu Arg Val Cys Lys Leu Ile Tyr Thr Val Met Glu Asn Asn
        675                 680                 685             
Ser Gly Arg Met Tyr Gly Ala Asp Asp Phe Leu Pro Val Leu Thr Tyr
    690                 695                 700                 
Val Ile Ala Gln Cys Asp Met Leu Glu Leu Asp Thr Glu Ile Glu Tyr
705                 710                 715                 720 
Met Met Glu Leu Leu Asp Pro Ser Leu Leu His Gly Glu Gly Gly Tyr
                725                 730                 735     
Tyr Leu Thr Ser Ala Tyr Gly Ala Leu Ser Leu Ile Lys Asn Phe Gln
            740                 745                 750         
Glu Glu Gln Ala Ala Arg Leu Leu Ser Ser Glu Thr Arg Asp Thr Leu
        755                 760                 765             
Arg Gln Trp His Lys Arg Arg Thr Thr Asn Arg Thr Ile Pro Ser Val
    770                 775                 780                 
Asp Asp Phe Gln Asn Tyr Leu Arg Val Ala Phe Gln Glu Val Asn Ser
785                 790                 795                 800 
Gly Cys Thr Gly Lys Thr Leu Leu Val Arg Pro Tyr Ile Thr Thr Glu
                805                 810                 815     
Asp Val Cys Gln Ile Cys Ala Glu Lys Phe Lys Val Gly Asp Pro Glu
            820                 825                 830         
Glu Tyr Ser Leu Phe Leu Phe Val Asp Glu Thr Trp Gln Gln Leu Ala
        835                 840                 845             
Glu Asp Thr Tyr Pro Gln Lys Ile Lys Ala Glu Leu His Ser Arg Pro
    850                 855                 860                 
Gln Pro His Ile Phe His Phe Val Tyr Lys Arg Ile Lys Asn Asp Pro
865                 870                 875                 880 
Tyr Gly Ile Ile Phe Gln Asn Gly Glu Glu Asp Leu Thr Thr Ser
                885                 890                 895 


<210> 8061
<211> 375
<212> PRT
<213> Homo sapiens

<400> 8061
Glu Val Leu Gln His Gln Lys Leu Ser Ala Asn Ala Pro Ala Thr Ala
 1               5                  10                  15      
Tyr Arg Asn Cys Cys Arg Leu Glu Ser Thr Ser Leu Pro Arg His Cys
            20                  25                  30          
Thr Ser Val Gly Asn Gln Val Ile Ala Val Val Met Asp Leu Phe Thr
        35                  40                  45              
Asp Gly Asp Ile Phe Gln Asp Ile Val Asp Ala Ala Cys Lys Arg Arg
    50                  55                  60                  
Val Pro Val Tyr Ile Ile Leu Asp Glu Ala Gly Val Lys Tyr Phe Leu
65                  70                  75                  80  
Glu Met Cys Gln Asp Leu Gln Leu Thr Asp Phe Arg Ile Arg Asn Ile
                85                  90                  95      
Arg Val Arg Ser Val Thr Gly Val Gly Phe Tyr Met Pro Met Gly Arg
            100                 105                 110         
Ile Lys Gly Thr Leu Ser Ser Arg Phe Leu Met Val Asp Gly Asp Lys
        115                 120                 125             
Val Ala Thr Gly Ser Tyr Arg Phe Thr Trp Ser Ser Ser His Val Asp
    130                 135                 140                 
Arg Asn Leu Leu Leu Leu Leu Thr Gly Gln Asn Val Glu Pro Phe Asp
145                 150                 155                 160 
Thr Glu Phe Arg Glu Leu Tyr Ala Ile Ser Glu Glu Val Asp Leu Tyr
                165                 170                 175     
Arg Gln Leu Ser Leu Ala Gly Arg Val Gly Leu His Tyr Ser Ser Thr
            180                 185                 190         
Val Ala Arg Lys Leu Ile Asn Pro Lys Tyr Ala Leu Val Ser Gly Cys
        195                 200                 205             
Arg His Pro Pro Gly Glu Met Met Arg Trp Ala Ala Arg Gln Gln Arg
    210                 215                 220                 
Glu Ala Gly Gly Asn Pro Glu Gly Gln Glu Glu Gly Ala Ser Gly Gly
225                 230                 235                 240 
Glu Ser Ala Trp Arg Leu Glu Ser Phe Leu Lys Asp Leu Val Thr Val
                245                 250                 255     
Glu Gln Val Leu Pro Pro Val Glu Pro Ile Pro Leu Gly Glu Leu Ser
            260                 265                 270         
Gln Lys Asp Gly Arg Met Val Ser His Met His Arg Asp Leu Lys Pro
        275                 280                 285             
Lys Ser Arg Glu Ala Pro Ser Arg Asn Gly Met Gly Glu Ala Ala Arg
    290                 295                 300                 
Gly Glu Ala Ala Pro Ala Arg Arg Phe Ser Ser Arg Leu Phe Ser Arg
305                 310                 315                 320 
Arg Ala Lys Arg Pro Ala Ala Pro Asn Gly Met Ala Ser Ser Val Ser
                325                 330                 335     
Thr Glu Thr Ser Glu Val Glu Phe Leu Thr Gly Lys Arg Pro Asn Glu
            340                 345                 350         
Asn Ser Ser Ala Asp Ile Ser Gly Lys Thr Ser Pro Ser Ser Ala Lys
        355                 360                 365             
Pro Ser Asn Cys Val Ile Ser
    370                 375 


<210> 8062
<211> 500
<212> PRT
<213> Homo sapiens

<400> 8062
Met Ala Glu Ser Gln Leu Asn Cys Leu Asp Glu Ala His Val Asn Glu
 1               5                  10                  15      
Lys Val Thr Glu Ala Gln Ala Ala Phe Tyr Tyr Cys Glu Arg Arg Arg
            20                  25                  30          
Ala Ala Leu Glu Ala Leu Leu Gly Gly Gly Glu Gln Ala Tyr Arg Glu
        35                  40                  45              
Arg Leu Lys Glu Glu Gln Leu Arg Asp Phe Leu Ser Ser Pro Glu Arg
    50                  55                  60                  
Gln Ala Leu Arg Ala Ala Trp Ser Pro Tyr Glu Asp Ala Val Pro Ala
65                  70                  75                  80  
Ala Asn Ala Arg Gly Lys Ser Lys Ala Lys Ala Lys Ala Pro Ala Pro
                85                  90                  95      
Ala Pro Ala Glu Ser Gly Glu Ser Leu Ala Tyr Trp Pro Asp Arg Ser
            100                 105                 110         
Asp Thr Glu Val Pro Pro Leu Asp Leu Gly Trp Thr Asp Thr Gly Phe
        115                 120                 125             
Tyr Arg Gly Val Ser Arg Val Thr Leu Phe Thr His Pro Pro Lys Asp
    130                 135                 140                 
Glu Lys Ala Pro His Leu Lys Gln Val Val Arg Gln Met Ile Gln Gln
145                 150                 155                 160 
Ala Gln Lys Val Ile Ala Val Val Met Asp Leu Phe Thr Asp Gly Asp
                165                 170                 175     
Ile Phe Gln Asp Ile Val Asp Ala Ala Cys Lys Arg Arg Val Pro Val
            180                 185                 190         
Tyr Ile Ile Leu Asp Glu Ala Gly Val Lys Tyr Phe Leu Glu Met Cys
        195                 200                 205             
Gln Asp Leu Gln Leu Thr Asp Phe Arg Ile Arg Asn Ile Arg Val Arg
    210                 215                 220                 
Ser Val Thr Gly Val Gly Phe Tyr Met Pro Met Gly Arg Ile Lys Gly
225                 230                 235                 240 
Thr Leu Ser Ser Arg Phe Leu Met Val Asp Gly Asp Lys Val Ala Thr
                245                 250                 255     
Gly Ser Tyr Arg Phe Thr Trp Ser Ser Ser His Val Asp Arg Asn Leu
            260                 265                 270         
Leu Leu Leu Leu Thr Gly Gln Asn Val Glu Pro Phe Asp Thr Glu Phe
        275                 280                 285             
Arg Glu Leu Tyr Ala Ile Ser Glu Glu Val Asp Leu Tyr Arg Gln Leu
    290                 295                 300                 
Ser Leu Ala Gly Arg Val Gly Leu His Tyr Ser Ser Thr Val Ala Arg
305                 310                 315                 320 
Lys Leu Ile Asn Pro Lys Tyr Ala Leu Val Ser Gly Cys Arg His Pro
                325                 330                 335     
Pro Gly Glu Met Met Arg Trp Ala Ala Arg Gln Gln Arg Glu Ala Gly
            340                 345                 350         
Gly Asn Pro Glu Gly Gln Glu Glu Gly Ala Ser Gly Gly Glu Ser Ala
        355                 360                 365             
Trp Arg Leu Glu Ser Phe Leu Lys Asp Leu Val Thr Val Glu Gln Val
    370                 375                 380                 
Leu Pro Pro Val Glu Pro Ile Pro Leu Gly Glu Leu Ser Gln Lys Asp
385                 390                 395                 400 
Gly Arg Met Val Ser His Met His Arg Asp Leu Lys Pro Lys Ser Arg
                405                 410                 415     
Glu Ala Pro Ser Arg Asn Gly Met Gly Glu Ala Ala Arg Gly Glu Ala
            420                 425                 430         
Ala Pro Ala Arg Arg Phe Ser Ser Arg Leu Phe Ser Arg Arg Ala Lys
        435                 440                 445             
Arg Pro Ala Ala Pro Asn Gly Met Ala Ser Ser Val Ser Thr Glu Thr
    450                 455                 460                 
Ser Glu Val Glu Phe Leu Thr Gly Lys Arg Pro Asn Glu Asn Ser Ser
465                 470                 475                 480 
Ala Asp Ile Ser Gly Lys Thr Ser Pro Ser Ser Ala Lys Pro Ser Asn
                485                 490                 495     
Cys Val Ile Ser
            500 


<210> 8063
<211> 1048
<212> PRT
<213> Homo sapiens

<400> 8063
Met Gln Ser Lys Val Thr Gly Asn Met Pro Thr Gln Ser Leu Leu Met
 1               5                  10                  15      
Tyr Met Asp Gly Pro Glu Val Ile Gly Ser Ser Leu Gly Ser Pro Met
            20                  25                  30          
Glu Met Glu Asp Ala Leu Ser Met Lys Gly Thr Ala Val Val Pro Phe
        35                  40                  45              
Arg Ala Thr Gln Glu Lys Asn Val Ile Gln Ile Glu Gly Tyr Met Pro
    50                  55                  60                  
Leu Asp Cys Met Phe Cys Ser Gln Thr Phe Thr His Ser Glu Asp Leu
65                  70                  75                  80  
Asn Lys His Val Leu Met Gln His Arg Pro Thr Leu Cys Glu Pro Ala
                85                  90                  95      
Val Leu Arg Val Glu Ala Glu Tyr Leu Ser Pro Leu Asp Lys Ser Gln
            100                 105                 110         
Val Arg Thr Glu Pro Pro Lys Glu Lys Asn Cys Lys Glu Asn Glu Phe
        115                 120                 125             
Ser Cys Glu Val Cys Gly Gln Thr Phe Arg Val Ala Phe Asp Val Glu
    130                 135                 140                 
Ile His Met Arg Thr His Lys Asp Ser Phe Thr Tyr Gly Cys Asn Met
145                 150                 155                 160 
Cys Gly Arg Arg Phe Lys Glu Pro Trp Phe Leu Lys Asn His Met Arg
                165                 170                 175     
Thr His Asn Gly Lys Ser Gly Ala Arg Ser Lys Leu Gln Gln Gly Leu
            180                 185                 190         
Glu Ser Ser Pro Ala Thr Ile Asn Glu Val Val Gln Val His Ala Ala
        195                 200                 205             
Glu Ser Ile Ser Ser Pro Tyr Lys Ile Cys Met Val Cys Gly Phe Leu
    210                 215                 220                 
Phe Pro Asn Lys Glu Ser Leu Ile Glu His Arg Lys Val His Thr Lys
225                 230                 235                 240 
Lys Thr Ala Phe Gly Thr Ser Ser Ala Gln Thr Asp Ser Pro Gln Gly
                245                 250                 255     
Gly Met Pro Ser Ser Arg Glu Asp Phe Leu Gln Leu Phe Asn Leu Arg
            260                 265                 270         
Pro Lys Ser His Pro Glu Thr Gly Lys Lys Pro Val Arg Cys Ile Pro
        275                 280                 285             
Gln Leu Asp Pro Phe Thr Thr Phe Gln Ala Trp Gln Leu Ala Thr Lys
    290                 295                 300                 
Gly Lys Val Ala Ile Cys Gln Glu Val Lys Glu Ser Gly Gln Glu Gly
305                 310                 315                 320 
Ser Thr Asp Asn Asp Asp Ser Ser Ser Glu Lys Glu Leu Gly Glu Thr
                325                 330                 335     
Asn Lys Gly Ser Cys Ala Gly Leu Ser Gln Glu Lys Glu Lys Cys Lys
            340                 345                 350         
His Ser His Gly Glu Ala Pro Ser Val Asp Ala Asp Pro Lys Leu Pro
        355                 360                 365             
Ser Ser Lys Glu Lys Pro Thr His Cys Ser Glu Cys Gly Lys Ala Phe
    370                 375                 380                 
Arg Thr Tyr His Gln Leu Val Leu His Ser Arg Val His Lys Lys Asp
385                 390                 395                 400 
Arg Arg Ala Gly Ala Glu Ser Pro Thr Met Ser Val Asp Gly Arg Gln
                405                 410                 415     
Pro Gly Thr Cys Ser Pro Asp Leu Ala Ala Pro Leu Asp Glu Asn Gly
            420                 425                 430         
Ala Val Asp Arg Gly Glu Gly Gly Ser Glu Asp Gly Ser Glu Asp Gly
        435                 440                 445             
Leu Pro Glu Gly Ile His Leu Asp Lys Asn Asp Asp Gly Gly Lys Ile
    450                 455                 460                 
Lys His Leu Thr Ser Ser Arg Glu Cys Ser Tyr Cys Gly Lys Phe Phe
465                 470                 475                 480 
Arg Ser Asn Tyr Tyr Leu Asn Ile His Leu Arg Thr His Thr Gly Glu
                485                 490                 495     
Lys Pro Tyr Lys Cys Glu Phe Cys Glu Tyr Ala Ala Ala Gln Lys Thr
            500                 505                 510         
Ser Leu Arg Tyr His Leu Glu Arg His His Lys Glu Lys Gln Thr Asp
        515                 520                 525             
Val Ala Ala Glu Val Lys Asn Asp Gly Lys Asn Gln Asp Thr Glu Asp
    530                 535                 540                 
Ala Leu Leu Thr Ala Asp Ser Ala Gln Thr Lys Asn Leu Lys Arg Phe
545                 550                 555                 560 
Phe Asp Gly Ala Lys Asp Val Thr Gly Ser Pro Pro Ala Lys Gln Leu
                565                 570                 575     
Lys Glu Met Pro Ser Val Phe Gln Asn Val Leu Gly Ser Ala Val Leu
            580                 585                 590         
Ser Pro Ala His Lys Asp Thr Gln Asp Phe His Lys Asn Ala Ala Asp
        595                 600                 605             
Asp Ser Ala Asp Lys Val Asn Lys Asn Pro Thr Pro Ala Tyr Leu Asp
    610                 615                 620                 
Leu Leu Lys Lys Arg Ser Ala Val Glu Thr Gln Ala Asn Asn Leu Ile
625                 630                 635                 640 
Cys Arg Thr Lys Ala Asp Val Thr Pro Pro Pro Asp Gly Ser Thr Thr
                645                 650                 655     
His Asn Leu Glu Val Ser Pro Lys Glu Lys Gln Thr Glu Thr Ala Ala
            660                 665                 670         
Asp Cys Arg Tyr Arg Pro Ser Val Asp Cys His Glu Lys Pro Leu Asn
        675                 680                 685             
Leu Ser Val Gly Ala Leu His Asn Cys Pro Ala Ile Ser Leu Ser Lys
    690                 695                 700                 
Ser Leu Ile Pro Ser Ile Thr Cys Pro Phe Cys Thr Phe Lys Thr Phe
705                 710                 715                 720 
Tyr Pro Glu Val Leu Met Met His Gln Arg Leu Glu His Lys Tyr Asn
                725                 730                 735     
Pro Asp Val His Lys Asn Cys Arg Asn Lys Ser Leu Leu Arg Ser Arg
            740                 745                 750         
Arg Thr Gly Cys Pro Pro Ala Leu Leu Gly Lys Asp Val Pro Pro Leu
        755                 760                 765             
Ser Ser Phe Cys Lys Pro Lys Pro Lys Ser Ala Phe Pro Ala Gln Ser
    770                 775                 780                 
Lys Ser Leu Pro Ser Ala Lys Gly Lys Gln Ser Pro Pro Gly Pro Gly
785                 790                 795                 800 
Lys Ala Pro Leu Thr Ser Gly Ile Asp Ser Ser Thr Leu Ala Pro Ser
                805                 810                 815     
Asn Leu Lys Ser His Arg Pro Gln Gln Asn Val Gly Val Gln Gly Ala
            820                 825                 830         
Ala Thr Arg Gln Gln Gln Ser Glu Met Phe Pro Lys Thr Ser Val Ser
        835                 840                 845             
Pro Ala Pro Asp Lys Thr Lys Arg Pro Glu Thr Lys Leu Lys Pro Leu
    850                 855                 860                 
Pro Val Ala Pro Ser Gln Pro Thr Leu Gly Ser Ser Asn Ile Asn Gly
865                 870                 875                 880 
Ser Ile Asp Tyr Pro Ala Lys Asn Asp Ser Pro Trp Ala Pro Pro Gly
                885                 890                 895     
Arg Asp Tyr Phe Cys Asn Arg Ser Ala Ser Asn Thr Ala Ala Glu Phe
            900                 905                 910         
Gly Glu Pro Leu Pro Lys Arg Leu Lys Ser Ser Val Val Ala Leu Asp
        915                 920                 925             
Val Asp Gln Pro Gly Ala Asn Tyr Arg Arg Gly Tyr Asp Leu Pro Lys
    930                 935                 940                 
Tyr His Met Val Arg Gly Ile Thr Ser Leu Leu Pro Gln Asp Cys Val
945                 950                 955                 960 
Tyr Pro Ser Gln Ala Leu Pro Pro Lys Pro Arg Phe Leu Ser Ser Ser
                965                 970                 975     
Glu Val Asp Ser Pro Asn Val Leu Thr Val Gln Lys Pro Tyr Gly Gly
            980                 985                 990         
Ser Gly Pro Leu Tyr Thr Cys Val Pro Ala Gly Ser Pro Ala Ser Ser
        995                 1000                1005            
Ser Thr Leu Glu Gly Lys Arg Pro Val Ser Tyr Gln His Leu Ser Asn
    1010                1015                1020                
Ser Met Ala Gln Lys Arg Asn Tyr Glu Asn Phe Ile Gly Asn Ala His
1025                1030                1035                1040
Tyr Arg Pro Asn Asp Lys Lys Thr
                1045            


<210> 8064
<211> 667
<212> PRT
<213> Homo sapiens

<400> 8064
Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu
 1               5                  10                  15      
Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Asn
            20                  25                  30          
Cys Ala His Arg Ile Leu Val Ser His Cys Ala Thr Asn Glu Ser Val
        35                  40                  45              
Glu Ser Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg His Val Ile Thr
    50                  55                  60                  
Leu Ser Gln Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln
65                  70                  75                  80  
Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser
                85                  90                  95      
Pro Ser Glu Thr Arg Arg Glu Arg Ala Phe Asp Ala Asn Thr Met Thr
            100                 105                 110         
Ser Ala Glu Lys Val Leu Cys Gln Phe Cys Asp Gln Asp Pro Ala Gln
        115                 120                 125             
Asp Ala Val Lys Thr Cys Val Thr Cys Glu Val Ser Tyr Cys Asp Glu
    130                 135                 140                 
Cys Leu Lys Ala Thr His Pro Asn Lys Lys Pro Phe Thr Gly His Arg
145                 150                 155                 160 
Leu Ile Glu Pro Ile Pro Asp Ser His Ile Arg Gly Leu Met Cys Leu
                165                 170                 175     
Glu His Glu Asp Glu Lys Val Asn Met Tyr Cys Val Thr Asp Asp Gln
            180                 185                 190         
Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp His Gln
        195                 200                 205             
Val Ala Ala Leu Ser Glu Arg Tyr Asp Lys Leu Lys Gln Asn Leu Glu
    210                 215                 220                 
Ser Asn Leu Thr Asn Leu Ile Lys Arg Asn Thr Glu Leu Glu Thr Leu
225                 230                 235                 240 
Leu Ala Lys Leu Ile Gln Thr Cys Gln His Val Glu Val Asn Ala Ser
                245                 250                 255     
Arg Gln Glu Ala Lys Leu Thr Glu Glu Cys Asp Leu Leu Ile Glu Ile
            260                 265                 270         
Ile Gln Gln Arg Arg Gln Ile Ile Gly Thr Lys Ile Lys Glu Gly Lys
        275                 280                 285             
Val Met Arg Leu Arg Lys Leu Ala Gln Gln Ile Ala Asn Cys Lys Gln
    290                 295                 300                 
Cys Ile Glu Arg Ser Ala Ser Leu Ile Ser Gln Ala Glu His Ser Leu
305                 310                 315                 320 
Lys Glu Asn Asp His Ala Arg Phe Leu Gln Thr Ala Lys Asn Ile Thr
                325                 330                 335     
Glu Arg Val Ser Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Glu
            340                 345                 350         
Ile Asn Leu Asn Asp Thr Phe Asp Thr Phe Ala Leu Asp Phe Ser Arg
        355                 360                 365             
Glu Lys Lys Leu Leu Glu Cys Leu Asp Tyr Leu Thr Ala Pro Asn Pro
    370                 375                 380                 
Pro Thr Ile Arg Glu Glu Leu Cys Thr Ala Ser Tyr Asp Thr Ile Thr
385                 390                 395                 400 
Val His Trp Thr Ser Asp Asp Glu Phe Ser Val Val Ser Tyr Glu Leu
                405                 410                 415     
Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Val Val Ser Leu Cys Asn
            420                 425                 430         
Ser Ala Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr
        435                 440                 445             
Thr Val His Gly Leu Gln Ser Gly Thr Lys Tyr Ile Phe Met Val Lys
    450                 455                 460                 
Ala Ile Asn Gln Ala Gly Ser Arg Ser Ser Glu Pro Gly Lys Leu Lys
465                 470                 475                 480 
Thr Asn Ser Gln Pro Phe Lys Leu Asp Pro Lys Ser Ala His Arg Lys
                485                 490                 495     
Leu Lys Val Ser His Asp Asn Leu Thr Val Glu Arg Asp Glu Ser Ser
            500                 505                 510         
Ser Lys Lys Ser His Thr Pro Glu Arg Phe Thr Ser Gln Gly Ser Tyr
        515                 520                 525             
Gly Val Ala Gly Asn Val Phe Ile Asp Ser Gly Arg His Tyr Trp Glu
    530                 535                 540                 
Val Val Ile Ser Gly Ser Thr Trp Tyr Ala Ile Gly Leu Ala Tyr Lys
545                 550                 555                 560 
Ser Ala Pro Lys His Glu Trp Ile Gly Lys Asn Ser Ala Ser Trp Ala
                565                 570                 575     
Leu Cys Arg Cys Asn Asn Asn Trp Val Val Arg His Asn Ser Lys Glu
            580                 585                 590         
Ile Pro Ile Glu Pro Ala Pro His Leu Arg Arg Val Gly Ile Leu Leu
        595                 600                 605             
Asp Tyr Asp Asn Gly Ser Ile Ala Phe Tyr Asp Ala Leu Asn Ser Ile
    610                 615                 620                 
His Leu Tyr Thr Phe Asp Val Ala Phe Ala Gln Pro Val Cys Pro Thr
625                 630                 635                 640 
Phe Thr Val Trp Asn Lys Cys Leu Thr Ile Ile Thr Gly Leu Pro Ile
                645                 650                 655     
Pro Asp His Leu Asp Cys Thr Glu Gln Leu Pro
            660                 665         


<210> 8065
<211> 552
<212> PRT
<213> Homo sapiens

<400> 8065
Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu
 1               5                  10                  15      
Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Asn
            20                  25                  30          
Cys Ala His Arg Ile Leu Val Ser His Cys Ala Thr Asn Glu Ser Val
        35                  40                  45              
Glu Ser Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg His Val Ile Thr
    50                  55                  60                  
Leu Ser Gln Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln
65                  70                  75                  80  
Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser
                85                  90                  95      
Pro Ser Glu Thr Arg Arg Glu Arg Ala Phe Asp Ala Asn Thr Met Thr
            100                 105                 110         
Ser Ala Glu Lys Val Leu Cys Gln Phe Cys Asp Gln Asp Pro Ala Gln
        115                 120                 125             
Asp Ala Val Lys Thr Cys Val Thr Cys Glu Val Ser Tyr Cys Asp Glu
    130                 135                 140                 
Cys Leu Lys Ala Thr His Pro Asn Lys Lys Pro Phe Thr Gly His Arg
145                 150                 155                 160 
Leu Ile Glu Pro Ile Pro Asp Ser His Ile Arg Gly Leu Met Cys Leu
                165                 170                 175     
Glu His Glu Asp Glu Lys Val Asn Met Tyr Cys Val Thr Asp Asp Gln
            180                 185                 190         
Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp His Gln
        195                 200                 205             
Val Ala Ala Leu Ser Glu Arg Tyr Asp Lys Leu Lys Gln Asn Leu Glu
    210                 215                 220                 
Ser Asn Leu Thr Asn Leu Ile Lys Arg Asn Thr Glu Leu Glu Thr Leu
225                 230                 235                 240 
Leu Ala Lys Leu Ile Gln Thr Cys Gln His Val Glu Val Asn Ala Ser
                245                 250                 255     
Arg Gln Glu Ala Lys Leu Thr Glu Glu Cys Asp Leu Leu Ile Glu Ile
            260                 265                 270         
Ile Gln Gln Arg Arg Gln Ile Ile Gly Thr Lys Ile Lys Glu Gly Lys
        275                 280                 285             
Val Met Arg Leu Arg Lys Leu Ala Gln Gln Ile Ala Asn Cys Lys Gln
    290                 295                 300                 
Cys Ile Glu Arg Ser Ala Ser Leu Ile Ser Gln Ala Glu His Ser Leu
305                 310                 315                 320 
Lys Glu Asn Asp His Ala Arg Phe Leu Gln Thr Ala Lys Asn Ile Thr
                325                 330                 335     
Glu Arg Val Ser Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Glu
            340                 345                 350         
Ile Asn Leu Asn Asp Thr Phe Asp Thr Phe Ala Leu Asp Phe Ser Arg
        355                 360                 365             
Glu Lys Lys Leu Leu Glu Cys Leu Asp Tyr Leu Thr Ala Pro Asn Pro
    370                 375                 380                 
Pro Thr Ile Arg Glu Glu Leu Cys Thr Ala Ser Tyr Asp Thr Ile Thr
385                 390                 395                 400 
Val His Trp Thr Ser Asp Asp Glu Phe Ser Val Val Ser Tyr Glu Leu
                405                 410                 415     
Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Val Val Ser Leu Cys Asn
            420                 425                 430         
Ser Ala Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr
        435                 440                 445             
Thr Val His Gly Leu Gln Ser Gly Thr Lys Tyr Ile Phe Met Val Lys
    450                 455                 460                 
Ala Ile Asn Gln Ala Gly Ser Arg Ser Ser Glu Pro Gly Lys Leu Lys
465                 470                 475                 480 
Thr Asn Ser Gln Pro Phe Lys Leu Asp Pro Lys Ser Ala His Arg Lys
                485                 490                 495     
Leu Lys Val Ser His Asp Asn Leu Thr Val Glu Arg Asp Glu Ser Ser
            500                 505                 510         
Ser Lys Lys Ser His Thr Pro Glu Arg Phe Thr Ser Gln Gly Ser Tyr
        515                 520                 525             
Gly Val Ala Gly Asn Val Phe Ile Asp Ser Gly Arg His Tyr Trp Glu
    530                 535                 540                 
Val Val Ile Ser Gly Ser Thr Trp
545                 550         


<210> 8066
<211> 1224
<212> PRT
<213> Homo sapiens

<400> 8066
Met Leu Pro Tyr Thr Val Asn Phe Lys Val Ser Ala Arg Thr Leu Thr
 1               5                  10                  15      
Gly Ala Leu Asn Ala His Asn Lys Ala Ala Val Asp Trp Gly Trp Gln
            20                  25                  30          
Gly Leu Ile Ala Tyr Gly Cys His Ser Leu Val Val Val Ile Asp Ser
        35                  40                  45              
Ile Thr Ala Gln Thr Leu Gln Val Leu Glu Lys His Lys Ala Asp Val
    50                  55                  60                  
Val Lys Val Lys Trp Ala Arg Glu Asn Tyr His His Asn Ile Gly Ser
65                  70                  75                  80  
Pro Tyr Cys Leu Arg Leu Ala Ser Ala Asp Val Asn Gly Lys Ile Ile
                85                  90                  95      
Val Trp Asp Val Ala Ala Gly Val Ala Gln Cys Glu Ile Gln Glu His
            100                 105                 110         
Ala Lys Pro Ile Gln Asp Val Gln Trp Leu Trp Asn Gln Asp Ala Ser
        115                 120                 125             
Arg Asp Leu Leu Leu Ala Ile His Pro Pro Asn Tyr Ile Val Leu Trp
    130                 135                 140                 
Asn Ala Asp Thr Gly Thr Lys Leu Trp Lys Lys Ser Tyr Ala Asp Asn
145                 150                 155                 160 
Ile Leu Ser Phe Ser Phe Asp Pro Phe Asp Pro Ser His Leu Thr Leu
                165                 170                 175     
Leu Thr Ser Glu Gly Ile Val Phe Ile Ser Asp Phe Ser Pro Ser Lys
            180                 185                 190         
Pro Pro Ser Gly Pro Gly Lys Lys Val Tyr Ile Ser Ser Pro His Ser
        195                 200                 205             
Ser Pro Ala His Asn Lys Leu Ala Thr Ala Thr Gly Ala Lys Lys Ala
    210                 215                 220                 
Leu Asn Lys Val Lys Ile Leu Ile Thr Gln Glu Lys Pro Ser Ala Glu
225                 230                 235                 240 
Phe Ile Thr Leu Asn Asp Cys Leu Gln Leu Ala Tyr Leu Pro Ser Lys
                245                 250                 255     
Arg Asn His Met Leu Leu Leu Tyr Pro Arg Glu Ile Leu Ile Leu Asp
            260                 265                 270         
Leu Glu Val Asn Gln Thr Val Gly Val Ile Ala Ile Glu Arg Thr Gly
        275                 280                 285             
Val Pro Phe Leu Gln Val Ile Pro Cys Phe Gln Arg Asp Gly Leu Phe
    290                 295                 300                 
Cys Leu His Glu Asn Gly Cys Ile Thr Leu Arg Val Arg Arg Ser Tyr
305                 310                 315                 320 
Asn Asn Ile Phe Thr Thr Ser Asn Glu Glu Pro Asp Pro Asp Pro Val
                325                 330                 335     
Gln Glu Leu Thr Tyr Asp Leu Arg Ser Gln Cys Asp Ala Ile Arg Val
            340                 345                 350         
Thr Lys Thr Val Arg Pro Phe Ser Met Val Cys Cys Pro Val Asn Glu
        355                 360                 365             
Asn Ala Ala Ala Leu Val Val Ser Asp Gly Arg Val Met Ile Trp Glu
    370                 375                 380                 
Leu Lys Ser Ala Val Cys Asn Arg Asn Ser Arg Asn Ser Ser Ser Gly
385                 390                 395                 400 
Val Ser Pro Leu Tyr Ser Pro Val Ser Phe Cys Gly Ile Pro Val Gly
                405                 410                 415     
Val Leu Gln Asn Lys Leu Pro Asp Leu Ser Leu Asp Asn Met Ile Gly
            420                 425                 430         
Gln Ser Ala Ile Ala Gly Glu Glu His Pro Arg Gly Ser Ile Leu Arg
        435                 440                 445             
Glu Val His Leu Lys Phe Leu Leu Thr Gly Leu Leu Ser Gly Leu Pro
    450                 455                 460                 
Ala Pro Gln Phe Ala Ile Arg Met Cys Pro Pro Leu Thr Thr Lys Asn
465                 470                 475                 480 
Ile Lys Met Tyr Gln Pro Leu Leu Ala Val Gly Thr Ser Asn Gly Ser
                485                 490                 495     
Val Leu Val Tyr His Leu Thr Ser Gly Leu Leu His Lys Glu Leu Ser
            500                 505                 510         
Ile His Ser Cys Glu Val Lys Gly Ile Glu Trp Thr Ser Leu Thr Ser
        515                 520                 525             
Phe Leu Ser Phe Ala Thr Ser Thr Pro Asn Asn Met Gly Leu Val Arg
    530                 535                 540                 
Asn Glu Leu Gln Leu Val Asp Leu Pro Thr Gly Arg Ser Ile Ala Phe
545                 550                 555                 560 
Arg Gly Glu Arg Gly Asn Asp Glu Ser Ala Ile Glu Met Ile Lys Val
                565                 570                 575     
Ser His Leu Lys Gln Tyr Leu Ala Val Val Phe Arg Asp Lys Pro Leu
            580                 585                 590         
Glu Leu Trp Asp Val Arg Thr Cys Thr Leu Leu Arg Glu Met Ser Lys
        595                 600                 605             
Asn Phe Pro Thr Ile Thr Ala Leu Glu Trp Ser Pro Ser His Asn Leu
    610                 615                 620                 
Lys Ser Leu Arg Lys Lys Gln Leu Ala Thr Arg Glu Ala Met Ala Arg
625                 630                 635                 640 
Gln Thr Val Val Ser Asp Thr Glu Leu Ser Ile Val Glu Ser Ser Val
                645                 650                 655     
Ile Ser Leu Leu Gln Glu Ala Glu Ser Lys Ser Glu Leu Ser Gln Asn
            660                 665                 670         
Ile Ser Ala Arg Glu His Phe Val Phe Thr Asp Ile Asp Gly Gln Val
        675                 680                 685             
Tyr His Leu Thr Val Glu Gly Asn Ser Val Lys Asp Ser Ala Arg Ile
    690                 695                 700                 
Pro Pro Asp Gly Ser Met Gly Ser Ile Thr Cys Ile Ala Trp Lys Gly
705                 710                 715                 720 
Asp Thr Leu Val Leu Gly Asp Met Asp Gly Asn Leu Asn Phe Trp Asp
                725                 730                 735     
Leu Lys Gly Arg Val Ser Arg Gly Ile Pro Thr His Arg Ser Trp Val
            740                 745                 750         
Arg Lys Ile Arg Phe Ala Pro Gly Lys Gly Asn Gln Lys Leu Ile Ala
        755                 760                 765             
Met Tyr Asn Asp Gly Ala Glu Val Trp Asp Thr Lys Glu Val Gln Met
    770                 775                 780                 
Val Ser Ser Leu Arg Ser Gly Arg Asn Val Thr Phe Arg Ile Leu Asp
785                 790                 795                 800 
Val Asp Trp Cys Thr Ser Asp Lys Val Ile Leu Ala Ser Asp Asp Gly
                805                 810                 815     
Cys Ile Arg Val Leu Glu Met Ser Met Lys Ser Ala Cys Phe Arg Met
            820                 825                 830         
Asp Glu Gln Glu Leu Thr Glu Pro Val Trp Cys Pro Tyr Leu Leu Val
        835                 840                 845             
Pro Arg Ala Ser Leu Ala Leu Lys Ala Phe Leu Leu His Gln Pro Trp
    850                 855                 860                 
Asn Gly Gln Tyr Ser Leu Asp Ile Ser His Val Asp Tyr Pro Glu Asn
865                 870                 875                 880 
Glu Glu Ile Lys Asn Leu Leu Gln Glu Gln Leu Asn Ser Leu Ser Asn
                885                 890                 895     
Asp Ile Lys Lys Leu Leu Leu Asp Pro Glu Phe Thr Leu Leu Gln Arg
            900                 905                 910         
Cys Leu Leu Val Ser Arg Leu Tyr Gly Asp Glu Ser Glu Leu His Phe
        915                 920                 925             
Trp Thr Val Ala Ala His Tyr Leu His Ser Leu Ser Gln Glu Lys Ser
    930                 935                 940                 
Ala Ser Thr Thr Ala Pro Lys Glu Ala Ala Pro Arg Asp Lys Leu Ser
945                 950                 955                 960 
Asn Pro Leu Asp Ile Cys Tyr Asp Val Leu Cys Glu Asn Ala Tyr Phe
                965                 970                 975     
Gln Lys Phe Gln Leu Glu Arg Val Asn Leu Gln Glu Val Lys Arg Ser
            980                 985                 990         
Thr Tyr Asp His Thr Arg Lys Cys Thr Asp Gln Leu Leu Leu Leu Gly
        995                 1000                1005            
Gln Thr Asp Arg Ala Val Gln Leu Leu Leu Glu Thr Ser Ala Asp Asn
    1010                1015                1020                
Gln His Tyr Tyr Cys Asp Ser Leu Lys Ala Cys Leu Val Thr Thr Val
1025                1030                1035                1040
Thr Ser Ser Gly Pro Ser Gln Ser Thr Ile Lys Leu Val Ala Thr Asn
                1045                1050                1055    
Met Ile Ala Asn Gly Lys Leu Ala Glu Gly Val Gln Leu Leu Cys Leu
            1060                1065                1070        
Ile Asp Lys Ala Ala Asp Ala Cys Arg Tyr Leu Gln Thr Tyr Gly Glu
        1075                1080                1085            
Trp Asn Arg Ala Ala Trp Leu Ala Lys Val Arg Leu Asn Pro Glu Glu
    1090                1095                1100                
Cys Ala Asp Val Leu Arg Arg Trp Val Asp His Leu Cys Ser Pro Gln
1105                1110                1115                1120
Val Asn Gln Lys Ser Lys Ala Leu Leu Val Leu Leu Ser Leu Gly Cys
                1125                1130                1135    
Phe Phe Ser Val Ala Glu Thr Leu His Ser Met Arg Tyr Phe Asp Arg
            1140                1145                1150        
Ala Ala Leu Phe Val Glu Ala Cys Leu Lys Tyr Gly Ala Phe Glu Val
        1155                1160                1165            
Thr Glu Asp Thr Glu Lys Leu Ile Thr Ala Ile Tyr Ala Asp Tyr Ala
    1170                1175                1180                
Arg Ser Leu Lys Asn Leu Gly Phe Lys Gln Gly Ala Val Leu Phe Ala
1185                1190                1195                1200
Ser Lys Ala Gly Ala Ala Gly Lys Asp Leu Leu Asn Glu Leu Glu Ser
                1205                1210                1215    
Pro Lys Glu Glu Pro Ile Glu Glu
            1220                


<210> 8067
<211> 911
<212> PRT
<213> Homo sapiens

<400> 8067
Met Ile Asp Leu Ser Phe Leu Thr Glu Glu Glu Gln Glu Ala Ile Met
 1               5                  10                  15      
Lys Val Leu Gln Arg Asp Ala Ala Leu Lys Arg Ala Glu Glu Glu Arg
            20                  25                  30          
Val Arg His Leu Pro Glu Lys Ile Lys Asp Asp Gln Gln Leu Lys Asn
        35                  40                  45              
Met Ser Gly Gln Trp Phe Tyr Glu Ala Lys Ala Lys Arg His Arg Asp
    50                  55                  60                  
Lys Ile His Gly Ala Asp Ile Ile Arg Ala Ser Met Arg Lys Lys Arg
65                  70                  75                  80  
Pro Gln Ile Ala Ala Glu Gln Ser Lys Asp Arg Glu Asn Gly Ala Lys
                85                  90                  95      
Glu Ser Trp Val Asn Asn Val Asn Lys Asp Ala Phe Leu Pro Pro Glu
            100                 105                 110         
Leu Ala Gly Val Val Glu Glu Pro Glu Glu Asp Ala Ala Pro Ala Ser
        115                 120                 125             
Pro Ser Ser Ser Val Val Asn Pro Ala Ser Ser Val Ile Asp Met Ser
    130                 135                 140                 
Gln Glu Asn Thr Arg Lys Pro Asn Val Ser Pro Glu Lys Arg Lys Asn
145                 150                 155                 160 
Pro Phe Asn Ser Ser Lys Leu Pro Glu Gly His Ser Ser Gln Gln Thr
                165                 170                 175     
Lys Asn Glu Gln Ser Lys Asn Gly Arg Thr Gly Leu Phe Gln Thr Ser
            180                 185                 190         
Lys Glu Asp Glu Leu Ser Glu Ser Lys Glu Lys Ser Thr Val Ala Asp
        195                 200                 205             
Thr Ser Ile Gln Lys Leu Glu Lys Ser Lys Gln Thr Leu Pro Gly Leu
    210                 215                 220                 
Ser Asn Gly Ser Gln Ile Lys Ala Pro Ile Pro Lys Ala Arg Lys Met
225                 230                 235                 240 
Ile Tyr Lys Ser Thr Asp Leu Asn Lys Asp Asp Asn Gln Ser Phe Pro
                245                 250                 255     
Arg Gln Arg Thr Asp Ser Leu Lys Ala Arg Gly Ala Pro Arg Gly Ile
            260                 265                 270         
Leu Lys Arg Asn Ser Ser Ser Ser Ser Thr Asp Ser Glu Thr Leu Arg
        275                 280                 285             
Tyr Asn His Asn Phe Glu Pro Lys Ser Lys Ile Val Ser Pro Gly Leu
    290                 295                 300                 
Thr Ile His Glu Arg Ile Ser Glu Lys Glu His Ser Leu Glu Asp Asn
305                 310                 315                 320 
Ser Ser Pro Asn Ser Leu Glu Pro Leu Lys His Val Arg Phe Ser Ala
                325                 330                 335     
Val Lys Asp Glu Leu Pro Gln Ser Pro Gly Leu Ile His Gly Arg Glu
            340                 345                 350         
Val Gly Glu Phe Ser Val Leu Glu Ser Asp Arg Leu Lys Asn Gly Met
        355                 360                 365             
Glu Asp Ala Gly Asp Thr Glu Glu Phe Gln Ser Asp Pro Lys Pro Ser
    370                 375                 380                 
Gln Tyr Arg Lys Pro Ser Leu Phe His Gln Ser Thr Ser Ser Pro Tyr
385                 390                 395                 400 
Val Ser Lys Ser Glu Thr His Gln Pro Met Thr Ser Gly Ser Phe Pro
                405                 410                 415     
Ile Asn Gly Leu His Ser His Ser Glu Val Leu Thr Ala Arg Pro Gln
            420                 425                 430         
Ser Met Glu Asn Ser Pro Thr Ile Asn Glu Pro Lys Asp Lys Ser Ser
        435                 440                 445             
Glu Leu Thr Arg Leu Glu Ser Val Leu Pro Arg Ser Pro Ala Asp Glu
    450                 455                 460                 
Leu Ser His Cys Val Glu Pro Glu Pro Ser Gln Val Pro Gly Gly Ser
465                 470                 475                 480 
Ser Arg Asp Arg Gln Gln Gly Ser Glu Glu Glu Pro Ser Pro Val Leu
                485                 490                 495     
Lys Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys Ser Leu
            500                 505                 510         
Glu Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp Asn Gln
        515                 520                 525             
Pro Glu Glu Leu Val Arg Ser Ala Glu Asp Asp Glu Lys Pro Asp Gln
    530                 535                 540                 
Lys Pro Val Thr Asn Glu Cys Val Pro Arg Ile Ser Thr Val Pro Thr
545                 550                 555                 560 
Gln Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg Met Ser
                565                 570                 575     
Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Ala Ser Phe Gly Ser Val
            580                 585                 590         
Met Ser Val Tyr Ser Gly Asp Phe Gly Asn Leu Glu Val Lys Gly Asn
        595                 600                 605             
Ile Gln Phe Ala Ile Glu Tyr Val Glu Ser Leu Lys Glu Leu His Val
    610                 615                 620                 
Phe Val Ala Gln Cys Lys Asp Leu Ala Ala Ala Asp Val Lys Lys Gln
625                 630                 635                 640 
Arg Ser Asp Pro Tyr Val Lys Ala Tyr Leu Leu Pro Asp Lys Gly Lys
                645                 650                 655     
Met Gly Lys Lys Lys Thr Leu Val Val Lys Lys Thr Leu Asn Pro Val
            660                 665                 670         
Tyr Asn Glu Ile Leu Arg Tyr Lys Ile Glu Lys Gln Ile Leu Lys Thr
        675                 680                 685             
Gln Lys Leu Asn Leu Ser Ile Trp His Arg Asp Thr Phe Lys Arg Asn
    690                 695                 700                 
Ser Phe Leu Gly Glu Val Glu Leu Asp Leu Glu Thr Trp Asp Trp Asp
705                 710                 715                 720 
Asn Lys Gln Asn Lys Gln Leu Arg Trp Tyr Pro Leu Lys Arg Lys Thr
                725                 730                 735     
Ala Pro Val Ala Leu Glu Ala Glu Asn Arg Gly Glu Met Lys Leu Ala
            740                 745                 750         
Leu Gln Tyr Val Pro Glu Pro Val Pro Gly Lys Lys Leu Pro Thr Thr
        755                 760                 765             
Gly Glu Val His Ile Trp Val Lys Glu Cys Leu Asp Leu Pro Leu Leu
    770                 775                 780                 
Arg Gly Ser His Leu Asn Ser Phe Val Lys Cys Thr Ile Leu Pro Asp
785                 790                 795                 800 
Thr Ser Arg Lys Ser Arg Gln Lys Thr Arg Ala Val Gly Lys Thr Thr
                805                 810                 815     
Asn Pro Ile Phe Asn His Thr Met Val Tyr Asp Gly Phe Arg Pro Glu
            820                 825                 830         
Asp Leu Met Glu Ala Cys Val Glu Leu Thr Val Trp Asp His Tyr Lys
        835                 840                 845             
Leu Thr Asn Gln Phe Leu Gly Gly Leu Arg Ile Gly Phe Gly Thr Gly
    850                 855                 860                 
Lys Ser Tyr Gly Thr Glu Val Asp Trp Met Asp Ser Thr Ser Glu Glu
865                 870                 875                 880 
Val Ala Leu Trp Glu Lys Met Val Asn Ser Pro Asn Thr Trp Ile Glu
                885                 890                 895     
Ala Thr Leu Pro Leu Arg Met Leu Leu Ile Ala Lys Ile Ser Lys
            900                 905                 910     


<210> 8068
<211> 471
<212> PRT
<213> Homo sapiens

<400> 8068
Met Ile Asp Leu Ser Phe Leu Thr Glu Glu Glu Gln Glu Ala Ile Met
 1               5                  10                  15      
Lys Val Leu Gln Arg Asp Ala Ala Leu Lys Arg Ala Glu Glu Glu Arg
            20                  25                  30          
Val Arg His Leu Pro Glu Lys Ile Lys Asp Asp Gln Gln Leu Lys Asn
        35                  40                  45              
Met Ser Gly Gln Trp Phe Tyr Glu Ala Lys Ala Lys Arg His Arg Asp
    50                  55                  60                  
Lys Ile His Gly Ala Asp Ile Ile Arg Ala Ser Met Arg Lys Lys Arg
65                  70                  75                  80  
Pro Gln Ile Ala Ala Glu Gln Ser Lys Asp Arg Glu Asn Gly Ala Lys
                85                  90                  95      
Glu Ser Trp Val Asn Asn Val Asn Lys Asp Ala Phe Leu Pro Pro Glu
            100                 105                 110         
Leu Ala Gly Val Val Glu Glu Pro Glu Glu Asp Ala Ala Pro Ala Ser
        115                 120                 125             
Pro Ser Ser Ser Val Val Asn Pro Ala Ser Ser Val Ile Asp Met Ser
    130                 135                 140                 
Gln Glu Asn Thr Arg Lys Pro Asn Val Ser Pro Glu Lys Arg Lys Asn
145                 150                 155                 160 
Pro Phe Asn Ser Ser Lys Leu Pro Glu Gly His Ser Ser Gln Gln Thr
                165                 170                 175     
Lys Asn Glu Gln Ser Lys Asn Gly Arg Thr Gly Leu Phe Gln Thr Ser
            180                 185                 190         
Lys Glu Asp Glu Leu Ser Glu Ser Lys Glu Lys Ser Thr Val Ala Asp
        195                 200                 205             
Thr Ser Ile Gln Lys Leu Glu Lys Ser Lys Gln Thr Leu Pro Gly Leu
    210                 215                 220                 
Ser Asn Gly Ser Gln Ile Lys Ala Pro Ile Pro Lys Ala Arg Lys Met
225                 230                 235                 240 
Ile Tyr Lys Ser Thr Asp Leu Asn Lys Asp Asp Asn Gln Ser Phe Pro
                245                 250                 255     
Arg Gln Arg Thr Asp Ser Leu Lys Ala Arg Gly Ala Pro Arg Gly Ile
            260                 265                 270         
Leu Lys Arg Asn Ser Ser Ser Ser Ser Thr Asp Ser Glu Thr Leu Arg
        275                 280                 285             
Tyr Asn His Asn Phe Glu Pro Lys Ser Lys Ile Val Ser Pro Gly Leu
    290                 295                 300                 
Thr Ile His Glu Arg Ile Ser Glu Lys Glu His Ser Leu Glu Asp Asn
305                 310                 315                 320 
Ser Ser Pro Asn Ser Leu Glu Pro Leu Lys His Val Arg Phe Ser Ala
                325                 330                 335     
Val Lys Asp Glu Leu Pro Gln Ser Pro Gly Leu Ile His Gly Arg Glu
            340                 345                 350         
Val Gly Glu Phe Ser Val Leu Glu Ser Asp Arg Leu Lys Asn Gly Met
        355                 360                 365             
Glu Asp Ala Gly Asp Thr Glu Glu Phe Gln Ser Asp Pro Lys Pro Ser
    370                 375                 380                 
Gln Tyr Arg Lys Pro Ser Leu Phe His Gln Ser Thr Ser Ser Pro Tyr
385                 390                 395                 400 
Val Ser Lys Ser Glu Thr His Gln Pro Met Thr Ser Gly Ser Phe Pro
                405                 410                 415     
Ile Asn Gly Leu His Ser His Ser Glu Val Leu Thr Ala Arg Pro Gln
            420                 425                 430         
Ser Met Glu Asn Ser Pro Thr Ile Asn Glu Pro Lys Asp Lys Ser Ser
        435                 440                 445             
Glu Leu Thr Arg Leu Glu Ser Val Leu Pro Arg Ser Pro Ala Gly Lys
    450                 455                 460                 
Arg Val Val Thr Thr Arg Leu
465                 470     


<210> 8069
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 8069
Met Pro Glu Gln Asp Lys Asp Pro Arg Val Gln Glu Asn Pro Asp Asp
 1               5                  10                  15      
His Arg Thr Val Pro Glu Val Thr Gly Asp Ala Arg Ser Ala Phe Trp
            20                  25                  30          
Pro Leu Arg Asp Asn Gly Gly Leu Ser Pro Phe Val Pro Arg Pro Gly
        35                  40                  45              
Pro Leu Gln Thr Asp Leu His Ala Gln Ser Ser Glu Ile Arg Tyr Asn
    50                  55                  60                  
Gln Thr Ser Gln Thr Ser Trp Thr Ser Ser Ser Thr Lys Arg Asn Ala
65                  70                  75                  80  
Ile Ser Ser Ser Tyr Ser Ser Thr Gly Gly Leu Pro Gly Leu Lys Gln
                85                  90                  95      
Arg Arg Gly Pro Ala Ser Ser Arg Cys Gln Leu Thr Leu Ser Tyr Ser
            100                 105                 110         
Lys Thr Val Ser Glu Asp Arg Pro Gln Ala Val Ser Ser Gly His Thr
        115                 120                 125             
Arg Cys Glu Lys Ala Ala Asp Thr Ala Pro Gly Gln Thr Leu Ala Pro
    130                 135                 140                 
Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser Arg Pro Arg Arg Arg Lys
145                 150                 155                 160 
Ile Pro Leu Leu Pro Ser Arg Arg Gly Glu Pro Leu Met Met Pro Pro
                165                 170                 175     
Pro Leu Glu Leu Gly Tyr Arg Val Thr Ala Glu Asp Leu His Leu Glu
            180                 185                 190         
Lys Gln Ala Ala Phe Gln Arg Ile Asn Ser Ala Leu His Val Glu Asp
        195                 200                 205             
Lys Ala Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser
    210                 215                 220                 
Ser Leu Ala Thr Gly Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro
225                 230                 235                 240 
Thr Met Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly
                245                 250                 255     
Leu Val Ala Pro Leu Ala Ser Ala Ala Glu Val Ser Ser Thr Ala Pro
            260                 265                 270         
Val Ser Gly Lys Lys Gln Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser
        275                 280                 285             
Asp Pro Leu Pro Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val
    290                 295                 300                 
Thr Ser Met Ile Pro Ala Pro Phe Thr Ala Ala Ser Arg Asp Ala Gly
305                 310                 315                 320 
Met Arg Arg Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro
                325                 330                 335     
Pro Ser Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp
            340                 345                 350         
Gly Gly Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala
        355                 360                 365             
Gln Arg Ser Glu Val Arg Tyr Asn Gln Arg Ser Gln Ile Ser Arg Thr
    370                 375                 380                 
Arg Ser Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr
385                 390                 395                 400 
Glu Gly Leu Pro Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His
                405                 410                 415     
Cys Gln Leu Ala His Ser Ser Ser Lys Thr Val Ser Glu Asp Gly Pro
            420                 425                 430         
Gln Ala Val Ser Ser Gly His Thr Arg Cys Glu Lys Arg Ala Asp Thr
        435                 440                 445             
Ala Pro Gly Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln
    450                 455                 460                 
Ala Ser Arg Pro His Ile Asn Ser Ala Leu His Val Glu Asp Lys Ala
465                 470                 475                 480 
Ile Ser Asp Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu
                485                 490                 495     
Ala Thr Gly Ala Ser Arg Gly Pro Pro Val Ser Lys Ala Pro Thr Met
            500                 505                 510         
Asp Ala Gln Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Leu
        515                 520                 525             
Ala Pro Leu Ala Ser Ala Ala Glu Leu Pro Ser Thr Ala Pro Val Ser
    530                 535                 540                 
Gly Lys Lys His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro
545                 550                 555                 560 
Leu Pro Ala Thr Ser Ser His Ser Arg Asp Ser Ala Gln Val Thr Ser
                565                 570                 575     
Met Ile Pro Ala Pro Phe Thr Ala Ala Ser Arg Asp Ala Gly Met Arg
            580                 585                 590         
Arg Thr Arg Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Pro Ser
        595                 600                 605             
Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Gly Gly
    610                 615                 620                 
Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Arg Arg
625                 630                 635                 640 
Ser Gln Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Tyr
                645                 650                 655     
Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu Gly
            660                 665                 670         
Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys Gln
        675                 680                 685             
Leu Ala Leu Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln Ala
    690                 695                 700                 
Val Ser Ser Arg His Thr Arg Cys Glu Lys Ala Asp Thr Ala Pro Gly
705                 710                 715                 720 
Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser Arg
                725                 730                 735     
Pro Arg Ile Asn Ser Ala Leu His Val Glu Asp Lys Ala Thr Ser Asp
            740                 745                 750         
Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr Gly
        755                 760                 765             
Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp Ala Gln
    770                 775                 780                 
Pro Asp Lys Leu Lys Ser Gln Asp Cys Leu Gly Leu Val Ala Ala Leu
785                 790                 795                 800 
Ala Ser Ala Thr Glu Val Ser Ser Thr Ala Pro Met Ser Gly Lys Lys
                805                 810                 815     
His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro Ala
            820                 825                 830         
Thr Ser Ser His Ser Gln Asp Ser Ala Gln Val Thr Ser Met Ile Pro
        835                 840                 845             
Ala Pro Phe Thr Ala Ala Ser Arg Asp Ala Ser Met Arg Arg Thr Arg
    850                 855                 860                 
Pro Gly Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Pro Ser
865                 870                 875                 880 
Thr Leu Asn Pro Thr Ser Gly Ser Leu Leu Asn Ala Val Asp Glu Gly
                885                 890                 895     
Pro Ser His Phe Leu Ala Ser Ala Thr Ala Ala Ala Arg Ala Arg Arg
            900                 905                 910         
Ser Gln Val Arg Tyr Asn Gln Arg Ser Gln Thr Ser Arg Thr Arg Ser
        915                 920                 925             
Cys Leu Lys Arg Asn Ala Ser Ser Ser Ser His Ser Ser Thr Glu Gly
    930                 935                 940                 
Leu Gln Glu Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser His Cys Gln
945                 950                 955                 960 
Leu Ala Leu Ser Ser Ser Asn Thr Val Ser Glu Asp Gly Pro Gln Ala
                965                 970                 975     
Val Ser Ser Arg Asp Thr Arg Cys Glu Lys Ala Asp Thr Ala Pro Gly
            980                 985                 990         
Gln Thr Leu Ala Pro Arg Gly Gly Ser Pro Arg Ser Gln Ala Ser Arg
        995                 1000                1005            
Pro Arg Ile Asn Ser Ala Leu His Val Glu Asp Lys Ala Ile Ser Asp
    1010                1015                1020                
Cys Arg Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr Gly
1025                1030                1035                1040
Ala Ser Gly Gly Pro Pro Val Ser Lys Ala Pro Thr Met Asp Ala Gln
                1045                1050                1055    
Gln Asp Arg Pro Lys Ser Gln Asp Cys Leu Gly Leu Val Ala Pro Leu
            1060                1065                1070        
Ala Ser Ala Ala Glu Val Ser Ser Thr Ala Pro Val Ser Gly Lys Lys
        1075                1080                1085            
His Arg Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro Ala
    1090                1095                1100                
Thr Ser Ser His Ser Gly Asp Ser Ala Gln Asp Thr Ser Leu Ile Pro
1105                1110                1115                1120
Ala Pro Phe Thr Pro Ala Ser Arg Asp Ala Gly Ala Arg Glu Gln Gln
                1125                1130                1135    
Asp Ala Leu Val Leu Tyr Gln Gln Asp Ala Phe Arg Val Asp Pro Thr
            1140                1145                1150        
Ala Thr Leu Ala Met Gly Thr Cys Gln Ser Pro Met
        1155                1160                


<210> 8070
<211> 1647
<212> PRT
<213> Homo sapiens

<400> 8070
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro
 1               5                  10                  15      
Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro
            20                  25                  30          
Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly
        35                  40                  45              
Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr
    50                  55                  60                  
Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His
65                  70                  75                  80  
Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met
                85                  90                  95      
Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro
            100                 105                 110         
Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu
        115                 120                 125             
His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln
    130                 135                 140                 
Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln
145                 150                 155                 160 
Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln
                165                 170                 175     
Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg
            180                 185                 190         
Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg
        195                 200                 205             
Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser
    210                 215                 220                 
Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro
225                 230                 235                 240 
Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly
                245                 250                 255     
Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met
            260                 265                 270         
Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro
        275                 280                 285             
Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro
    290                 295                 300                 
Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro
305                 310                 315                 320 
Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro
                325                 330                 335     
Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile
            340                 345                 350         
Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln
        355                 360                 365             
Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu
    370                 375                 380                 
Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala
385                 390                 395                 400 
Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu
                405                 410                 415     
Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr
            420                 425                 430         
Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg
        435                 440                 445             
Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln
    450                 455                 460                 
Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu
465                 470                 475                 480 
Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys
                485                 490                 495     
Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu
            500                 505                 510         
Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg
        515                 520                 525             
Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln
    530                 535                 540                 
Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr
545                 550                 555                 560 
Val Ala Asn Leu Thr Glu Leu Val Pro Gln His Lys Ala Ala Gln Val
                565                 570                 575     
Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala
            580                 585                 590         
Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu
        595                 600                 605             
Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser
    610                 615                 620                 
Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu
625                 630                 635                 640 
Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp
                645                 650                 655     
Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            660                 665                 670         
Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys
        675                 680                 685             
Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg
    690                 695                 700                 
His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val
705                 710                 715                 720 
Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His
                725                 730                 735     
Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly
            740                 745                 750         
Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu
        755                 760                 765             
Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly
    770                 775                 780                 
Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys
785                 790                 795                 800 
Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser
                805                 810                 815     
Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val
            820                 825                 830         
Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu
        835                 840                 845             
Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile
    850                 855                 860                 
Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val
865                 870                 875                 880 
Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val
                885                 890                 895     
Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr
            900                 905                 910         
Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu
        915                 920                 925             
Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn
    930                 935                 940                 
Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu
945                 950                 955                 960 
Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu
                965                 970                 975     
Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val
            980                 985                 990         
Glu Tyr Val Ile Lys Cys Asp Met Ser Ala Leu Gln Arg Val Leu Tyr
        995                 1000                1005            
Arg His Met Gln Ala Lys Gly Val Leu Leu Thr Asp Gly Ser Glu Lys
    1010                1015                1020                
Asp Lys Lys Gly Lys Gly Gly Thr Lys Thr Leu Met Asn Thr Ile Met
1025                1030                1035                1040
Gln Leu Arg Lys Ile Cys Asn His Pro Tyr Met Phe Gln His Ile Glu
                1045                1050                1055    
Glu Ser Phe Ser Glu His Leu Gly Phe Thr Gly Gly Ile Val Gln Gly
            1060                1065                1070        
Leu Asp Leu Tyr Arg Ala Ser Gly Lys Phe Glu Leu Leu Asp Arg Ile
        1075                1080                1085            
Leu Pro Lys Leu Arg Ala Thr Asn His Lys Val Leu Leu Phe Cys Gln
    1090                1095                1100                
Met Thr Ser Leu Met Thr Ile Met Glu Asp Tyr Phe Ala Tyr Arg Gly
1105                1110                1115                1120
Phe Lys Tyr Leu Arg Leu Asp Gly Thr Thr Lys Ala Glu Asp Arg Gly
                1125                1130                1135    
Met Leu Leu Lys Thr Phe Asn Glu Pro Gly Ser Glu Tyr Phe Ile Phe
            1140                1145                1150        
Leu Leu Ser Thr Arg Ala Gly Gly Leu Gly Leu Asn Leu Gln Ser Ala
        1155                1160                1165            
Asp Thr Val Ile Ile Phe Asp Ser Asp Trp Asn Pro His Gln Asp Leu
    1170                1175                1180                
Gln Ala Gln Asp Arg Ala His Arg Ile Gly Gln Gln Asn Glu Val Arg
1185                1190                1195                1200
Val Leu Arg Leu Cys Thr Val Asn Ser Val Glu Glu Lys Ile Leu Ala
                1205                1210                1215    
Ala Ala Lys Tyr Lys Leu Asn Val Asp Gln Lys Val Ile Gln Ala Gly
            1220                1225                1230        
Met Phe Asp Gln Lys Ser Ser Ser His Glu Arg Arg Ala Phe Leu Gln
        1235                1240                1245            
Ala Ile Leu Glu His Glu Glu Gln Asp Glu Ser Arg His Cys Ser Thr
    1250                1255                1260                
Gly Ser Gly Ser Ala Ser Phe Ala His Thr Ala Pro Pro Pro Ala Gly
1265                1270                1275                1280
Val Asn Pro Asp Leu Glu Glu Pro Pro Leu Lys Glu Glu Asp Glu Val
                1285                1290                1295    
Pro Asp Asp Glu Thr Val Asn Gln Met Ile Ala Arg His Glu Glu Glu
            1300                1305                1310        
Phe Asp Leu Phe Met Arg Met Asp Leu Asp Arg Arg Arg Glu Glu Ala
        1315                1320                1325            
Arg Asn Pro Lys Arg Lys Pro Arg Leu Met Glu Glu Asp Glu Leu Pro
    1330                1335                1340                
Ser Trp Ile Ile Lys Asp Asp Ala Glu Val Glu Arg Leu Thr Cys Glu
1345                1350                1355                1360
Glu Glu Glu Glu Lys Met Phe Gly Arg Gly Ser Arg His Arg Lys Glu
                1365                1370                1375    
Val Asp Tyr Ser Asp Ser Leu Thr Glu Lys Gln Trp Leu Lys Ala Ile
            1380                1385                1390        
Glu Glu Gly Thr Leu Glu Glu Ile Glu Glu Glu Val Arg Gln Lys Lys
        1395                1400                1405            
Ser Ser Arg Lys Arg Lys Arg Asp Ser Asp Ala Gly Ser Ser Thr Pro
    1410                1415                1420                
Thr Thr Ser Thr Arg Ser Arg Asp Lys Asp Asp Glu Ser Lys Lys Gln
1425                1430                1435                1440
Lys Lys Arg Gly Arg Pro Pro Ala Glu Lys Leu Ser Pro Asn Pro Pro
                1445                1450                1455    
Asn Leu Thr Lys Lys Met Lys Lys Ile Val Asp Ala Val Ile Lys Tyr
            1460                1465                1470        
Lys Asp Ser Ser Ser Gly Arg Gln Leu Ser Glu Val Phe Ile Gln Leu
        1475                1480                1485            
Pro Ser Arg Lys Glu Leu Pro Glu Tyr Tyr Glu Leu Ile Arg Lys Pro
    1490                1495                1500                
Val Asp Phe Lys Lys Ile Lys Glu Arg Ile Arg Asn His Lys Tyr Arg
1505                1510                1515                1520
Ser Leu Asn Asp Leu Glu Lys Asp Val Met Leu Leu Cys Gln Asn Ala
                1525                1530                1535    
Gln Thr Phe Asn Leu Glu Gly Ser Leu Ile Tyr Glu Asp Ser Ile Val
            1540                1545                1550        
Leu Gln Ser Val Phe Thr Ser Val Arg Gln Lys Ile Glu Lys Glu Asp
        1555                1560                1565            
Asp Ser Glu Gly Glu Glu Ser Glu Glu Glu Glu Glu Gly Glu Glu Glu
    1570                1575                1580                
Gly Ser Glu Ser Glu Ser Arg Ser Val Lys Val Lys Ile Lys Leu Gly
1585                1590                1595                1600
Arg Lys Glu Lys Ala Gln Asp Arg Leu Lys Gly Gly Arg Arg Arg Pro
                1605                1610                1615    
Ser Arg Gly Ser Arg Ala Lys Pro Val Val Ser Asp Asp Asp Ser Glu
            1620                1625                1630        
Glu Glu Gln Glu Glu Asp Arg Ser Gly Ser Gly Ser Glu Glu Asp
        1635                1640                1645        


<210> 8071
<211> 899
<212> PRT
<213> Homo sapiens

<400> 8071
Leu Arg Glu His Leu Glu Arg Leu Arg Ala Ala Leu Arg Gly Gly Pro
 1               5                  10                  15      
Glu Asp Ala Glu Val Glu Val Glu Pro Cys Lys Phe Ala Gly Pro Arg
            20                  25                  30          
Ala Gln Asn Asn Ser Ala His Gly Asp Tyr Met Gln Asn Asn Glu Ser
        35                  40                  45              
Ser Leu Ile Glu Gln Ala Pro Ile Pro Gln Asp Gly Leu Thr Val Ala
    50                  55                  60                  
Pro His Arg Ala Gln Arg Glu Ala Val His Ile Glu Lys Ile Met Leu
65                  70                  75                  80  
Lys Gly Val Gln Arg Lys Arg Ala Asp Lys Tyr Trp Glu Tyr Thr Phe
                85                  90                  95      
Lys Val Asn Trp Ser Asp Leu Ser Val Thr Thr Val Thr Lys Thr His
            100                 105                 110         
Gln Glu Leu Gln Glu Phe Leu Leu Lys Leu Pro Lys Glu Leu Ser Ser
        115                 120                 125             
Glu Thr Phe Asp Lys Thr Ile Leu Arg Ala Leu Asn Gln Gly Ser Leu
    130                 135                 140                 
Lys Arg Glu Glu Arg Arg His Pro Asp Leu Glu Pro Ile Leu Arg Gln
145                 150                 155                 160 
Leu Phe Ser Ser Ser Ser Gln Ala Phe Leu Gln Ser Gln Lys Val His
                165                 170                 175     
Ser Phe Phe Gln Ser Ile Ser Ser Asp Ser Leu His Ser Ile Asn Asn
            180                 185                 190         
Leu Gln Ser Ser Leu Lys Thr Ser Lys Ile Leu Glu His Leu Lys Glu
        195                 200                 205             
Asp Ser Ser Glu Ala Ser Ser Gln Glu Glu Asp Val Leu Gln His Ala
    210                 215                 220                 
Ile Ile His Lys Arg His Thr Gly Lys Ser Pro Ile Val Asn Asn Ile
225                 230                 235                 240 
Gly Thr Ser Cys Ser Pro Leu Asp Gly Leu Thr Met Gln Tyr Ser Glu
                245                 250                 255     
Gln Asn Gly Ile Val Asp Trp Arg Lys Gln Ser Cys Thr Thr Ile Gln
            260                 265                 270         
His Pro Glu His Cys Val Thr Ser Ala Asp Gln His Ser Ala Glu Lys
        275                 280                 285             
Arg Ser Leu Ser Ser Ile Asn Lys Lys Lys Gly Lys Pro Gln Thr Glu
    290                 295                 300                 
Lys Glu Lys Ile Lys Lys Thr Asp Asn Arg Leu Asn Ser Arg Ile Asn
305                 310                 315                 320 
Gly Ile Arg Leu Ser Thr Pro Gln His Ala His Gly Gly Thr Val Lys
                325                 330                 335     
Asp Val Asn Leu Asp Ile Gly Ser Gly His Asp Thr Cys Gly Glu Thr
            340                 345                 350         
Ser Ser Glu Ser Tyr Ser Ser Pro Ser Ser Pro Arg His Asp Gly Arg
        355                 360                 365             
Glu Ser Phe Glu Ser Glu Glu Glu Lys Asp Arg Asp Thr Asp Ser Asn
    370                 375                 380                 
Ser Glu Asp Ser Gly Asn Pro Ser Thr Thr Arg Phe Thr Gly Tyr Gly
385                 390                 395                 400 
Ser Val Asn Gln Thr Val Thr Val Lys Pro Pro Val Gln Ile Ala Ser
                405                 410                 415     
Leu Gly Asn Glu Asn Gly Asn Leu Leu Glu Asp Pro Leu Asn Ser Pro
            420                 425                 430         
Lys Tyr Gln His Ile Ser Phe Met Pro Thr Leu His Cys Val Met His
        435                 440                 445             
Asn Gly Ala Gln Lys Ser Glu Val Val Val Pro Ala Pro Lys Pro Ala
    450                 455                 460                 
Asp Gly Lys Thr Ile Gly Met Leu Val Pro Ser Pro Val Ala Ile Ser
465                 470                 475                 480 
Ala Ile Arg Glu Ser Ala Asn Ser Thr Pro Val Gly Ile Leu Gly Pro
                485                 490                 495     
Thr Ala Cys Thr Gly Glu Ser Glu Lys His Leu Glu Leu Leu Ala Ser
            500                 505                 510         
Pro Leu Pro Ile Pro Ser Thr Phe Leu Pro Tyr Ser Ser Thr Pro Ala
        515                 520                 525             
Leu His Leu Thr Val Gln Arg Leu Lys Leu Pro Pro Pro Gln Gly Ser
    530                 535                 540                 
Ser Glu Ser Cys Thr Val Asn Ile Pro Gln Gln Pro Pro Gly Ser Leu
545                 550                 555                 560 
Ser Ile Ala Ser Pro Asn Thr Ala Phe Ile Pro Ile His Asn Pro Gly
                565                 570                 575     
Ser Phe Pro Gly Ser Pro Val Ala Thr Thr Asp Pro Ile Thr Lys Ser
            580                 585                 590         
Ala Ser Gln Val Val Gly Leu Asn Gln Met Val Pro Gln Ile Glu Gly
        595                 600                 605             
Asn Thr Gly Thr Val Pro Gln Pro Thr Asn Val Lys Val Val Leu Pro
    610                 615                 620                 
Ala Ala Gly Leu Ser Ala Ala Gln Pro Pro Ala Ser Tyr Pro Leu Pro
625                 630                 635                 640 
Gly Ser Pro Leu Ala Ala Gly Val Leu Pro Ser Gln Asn Ser Ser Val
                645                 650                 655     
Leu Ser Thr Ala Ala Thr Ser Pro Gln Pro Ala Ser Ala Gly Ile Ser
            660                 665                 670         
Gln Ala Gln Ala Thr Val Pro Pro Ala Val Pro Thr His Thr Pro Gly
        675                 680                 685             
Pro Ala Pro Ser Pro Ser Pro Ala Leu Thr His Ser Thr Ala Gln Ser
    690                 695                 700                 
Asp Ser Thr Ser Tyr Ile Ser Ala Val Gly Asn Thr Asn Ala Asn Gly
705                 710                 715                 720 
Thr Val Val Pro Pro Gln Gln Met Gly Ser Gly Pro Cys Gly Ser Cys
                725                 730                 735     
Gly Arg Arg Cys Ser Cys Gly Thr Asn Gly Asn Leu Gln Leu Asn Ser
            740                 745                 750         
Tyr Tyr Tyr Pro Asn Pro Met Pro Gly Pro Met Tyr Arg Val Pro Ser
        755                 760                 765             
Phe Phe Thr Leu Pro Ser Ile Cys Asn Gly Ser Tyr Leu Asn Gln Ala
    770                 775                 780                 
His Gln Ser Asn Gly Asn Gln Leu Pro Phe Phe Leu Pro Gln Thr Pro
785                 790                 795                 800 
Tyr Ala Asn Gly Leu Val His Asp Pro Val Met Gly Ser Gln Ala Asn
                805                 810                 815     
Tyr Gly Met Gln Gln Met Ala Gly Phe Gly Arg Phe Tyr Pro Val Tyr
            820                 825                 830         
Pro Ala Pro Asn Val Val Ala Asn Thr Ser Gly Ser Gly Pro Lys Lys
        835                 840                 845             
Asn Gly Asn Val Ser Cys Tyr Asn Cys Gly Val Ser Gly His Tyr Ala
    850                 855                 860                 
Gln Asp Cys Lys Gln Ser Ser Met Glu Ala Asn Gln Gln Gly Thr Tyr
865                 870                 875                 880 
Arg Leu Arg Tyr Ala Pro Pro Leu Pro Pro Ser Asn Asp Thr Leu Asp
                885                 890                 895     
Ser Ala Asp
            


<210> 8072
<211> 739
<212> PRT
<213> Homo sapiens

<400> 8072
Met Ala Pro Gln Lys His Gly Gly Gly Gly Gly Gly Gly Ser Gly Pro
 1               5                  10                  15      
Ser Ala Gly Ser Gly Gly Gly Gly Phe Gly Gly Ser Ala Ala Val Ala
            20                  25                  30          
Ala Ala Thr Ala Ser Gly Gly Lys Ser Gly Gly Gly Ser Cys Gly Gly
        35                  40                  45              
Gly Gly Ser Tyr Ser Ala Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala
    50                  55                  60                  
Gly Ala Ala Val Leu Pro Val Lys Lys Pro Lys Met Glu His Val Gln
65                  70                  75                  80  
Ala Asp His Glu Leu Phe Leu Gln Ala Phe Glu Lys Pro Thr Gln Ile
                85                  90                  95      
Tyr Arg Phe Leu Arg Thr Arg Asn Leu Ile Ala Pro Ile Phe Leu His
            100                 105                 110         
Arg Thr Leu Thr Tyr Met Ser His Arg Asn Ser Arg Thr Asn Ile Lys
        115                 120                 125             
Arg Lys Thr Phe Lys Val Asp Asp Met Leu Ser Lys Val Glu Lys Met
    130                 135                 140                 
Lys Gly Glu Gln Glu Ser His Ser Leu Ser Ala His Leu Gln Leu Thr
145                 150                 155                 160 
Phe Thr Gly Phe Phe His Lys Asn Asp Lys Pro Ser Pro Asn Ser Glu
                165                 170                 175     
Asn Glu Gln Asn Ser Val Thr Leu Glu Val Leu Leu Val Lys Val Cys
            180                 185                 190         
His Lys Lys Arg Lys Asp Val Ser Cys Pro Ile Arg Gln Val Pro Thr
        195                 200                 205             
Gly Lys Lys Gln Val Pro Leu Ile Pro Asp Leu Asn Gln Thr Lys Pro
    210                 215                 220                 
Gly Asn Phe Pro Ser Leu Ala Val Ser Ser Asn Glu Phe Glu Pro Ser
225                 230                 235                 240 
Asn Ser His Met Val Lys Ser Tyr Ser Leu Leu Phe Arg Val Thr Arg
                245                 250                 255     
Pro Gly Arg Arg Glu Phe Asn Gly Met Ile Asn Gly Glu Thr Asn Glu
            260                 265                 270         
Asn Ile Asp Val Asn Glu Glu Leu Pro Ala Arg Arg Lys Arg Asn Arg
        275                 280                 285             
Glu Asp Gly Glu Lys Thr Phe Val Ala Gln Met Thr Val Phe Asp Lys
    290                 295                 300                 
Asn Arg Arg Leu Gln Leu Leu Asp Gly Glu Tyr Glu Val Ala Met Gln
305                 310                 315                 320 
Glu Met Glu Glu Cys Pro Ile Ser Lys Lys Arg Ala Thr Trp Glu Thr
                325                 330                 335     
Ile Leu Asp Gly Lys Arg Leu Pro Pro Phe Glu Thr Phe Ser Gln Gly
            340                 345                 350         
Pro Thr Leu Gln Phe Thr Leu Arg Trp Thr Gly Glu Thr Asn Asp Lys
        355                 360                 365             
Ser Thr Ala Pro Ile Ala Lys Pro Leu Ala Thr Arg Asn Ser Glu Ser
    370                 375                 380                 
Leu His Gln Glu Asn Lys Pro Gly Ser Val Lys Pro Thr Gln Thr Ile
385                 390                 395                 400 
Ala Val Lys Glu Ser Leu Thr Thr Asp Leu Gln Thr Arg Lys Glu Lys
                405                 410                 415     
Asp Thr Pro Asn Glu Asn Arg Gln Lys Leu Arg Ile Phe Tyr Gln Phe
            420                 425                 430         
Leu Tyr Asn Asn Asn Thr Arg Gln Gln Thr Glu Ala Arg Asp Asp Leu
        435                 440                 445             
His Cys Pro Trp Cys Thr Leu Asn Cys Arg Lys Leu Tyr Ser Leu Leu
    450                 455                 460                 
Lys His Leu Lys Leu Cys His Ser Arg Phe Ile Phe Asn Tyr Val Tyr
465                 470                 475                 480 
His Pro Lys Gly Ala Arg Ile Asp Val Ser Ile Asn Glu Cys Tyr Asp
                485                 490                 495     
Gly Ser Tyr Ala Gly Asn Pro Gln Asp Ile His Arg Gln Pro Gly Phe
            500                 505                 510         
Ala Phe Ser Arg Asn Gly Pro Val Lys Arg Thr Pro Ile Thr His Ile
        515                 520                 525             
Leu Val Cys Arg Pro Lys Arg Thr Lys Ala Ser Met Ser Glu Phe Leu
    530                 535                 540                 
Glu Ser Glu Asp Gly Glu Val Glu Gln Gln Arg Thr Tyr Ser Ser Gly
545                 550                 555                 560 
His Asn Arg Leu Tyr Phe His Ser Asp Thr Cys Leu Pro Leu Arg Pro
                565                 570                 575     
Gln Glu Met Glu Val Asp Ser Glu Asp Glu Lys Asp Pro Glu Trp Leu
            580                 585                 590         
Arg Glu Lys Thr Ile Thr Gln Ile Glu Glu Phe Ser Asp Val Asn Glu
        595                 600                 605             
Gly Glu Lys Glu Val Met Lys Leu Trp Asn Leu His Val Met Lys His
    610                 615                 620                 
Gly Phe Ile Ala Asp Asn Gln Met Asn His Ala Cys Met Leu Phe Val
625                 630                 635                 640 
Glu Asn Tyr Gly Gln Lys Ile Ile Lys Lys Asn Leu Cys Arg Asn Phe
                645                 650                 655     
Met Leu His Leu Val Ser Met His Asp Phe Asn Leu Ile Ser Ile Met
            660                 665                 670         
Ser Ile Asp Lys Ala Val Thr Lys Leu Arg Glu Met Gln Gln Lys Leu
        675                 680                 685             
Glu Lys Gly Glu Ser Ala Ser Pro Ala Asn Glu Glu Ile Thr Glu Glu
    690                 695                 700                 
Gln Asn Gly Thr Ala Asn Gly Phe Ser Glu Ile Asn Ser Lys Glu Lys
705                 710                 715                 720 
Ala Leu Glu Thr Asp Ser Val Ser Gly Val Ser Lys Gln Ser Lys Lys
                725                 730                 735     
Gln Lys Leu
            


<210> 8073
<211> 1132
<212> PRT
<213> Homo sapiens

<400> 8073
Met Glu Leu Phe Gln Ala Lys Asp His Tyr Ile Leu Gln Gln Gly Glu
 1               5                  10                  15      
Arg Ala Leu Trp Cys Ser Arg Arg Asp Gly Gly Leu Gln Leu Arg Pro
            20                  25                  30          
Ala Thr Asp Leu Leu Leu Ala Trp Asn Pro Ile Cys Leu Gly Leu Val
        35                  40                  45              
Glu Gly Val Ile Gly Lys Ile Gln Leu His Ser Asp Leu Pro Trp Trp
    50                  55                  60                  
Leu Ile Leu Ile Arg Gln Lys Ala Leu Val Gly Lys Leu Pro Gly Asp
65                  70                  75                  80  
His Glu Val Cys Lys Val Thr Lys Ile Ala Val Leu Ser Leu Ser Glu
                85                  90                  95      
Met Glu Pro Gln Asp Leu Glu Leu Glu Leu Cys Lys Lys His His Phe
            100                 105                 110         
Gly Ile Asn Lys Pro Glu Lys Ile Ile Pro Ser Pro Asp Asp Ser Lys
        115                 120                 125             
Phe Leu Leu Lys Thr Phe Thr His Ile Lys Ser Asn Val Ser Ala Pro
    130                 135                 140                 
Asn Lys Lys Lys Val Lys Glu Ser Lys Glu Lys Glu Lys Leu Glu Arg
145                 150                 155                 160 
Arg Leu Leu Glu Glu Leu Leu Lys Met Phe Met Asp Ser Glu Ser Phe
                165                 170                 175     
Tyr Tyr Ser Leu Thr Tyr Asp Leu Thr Asn Ser Val Gln Arg Gln Ser
            180                 185                 190         
Thr Gly Glu Arg Asp Gly Arg Pro Leu Trp Gln Lys Val Asp Asp Arg
        195                 200                 205             
Phe Phe Trp Asn Lys Tyr Met Ile Gln Asp Leu Thr Glu Ile Gly Thr
    210                 215                 220                 
Pro Asp Val Asp Phe Trp Ile Ile Pro Met Ile Gln Gly Phe Val Gln
225                 230                 235                 240 
Ile Glu Glu Leu Val Val Asn Tyr Thr Glu Ser Ser Asp Asp Glu Lys
                245                 250                 255     
Ser Ser Pro Glu Thr Pro Pro Gln Glu Ser Thr Cys Val Asp Asp Ile
            260                 265                 270         
His Pro Arg Phe Leu Val Ala Leu Ile Ser Arg Arg Ser Arg His Arg
        275                 280                 285             
Ala Gly Met Arg Tyr Lys Arg Arg Gly Val Asp Lys Asn Gly Asn Val
    290                 295                 300                 
Ala Asn Tyr Val Glu Thr Glu Gln Leu Ile His Val His Asn His Thr
305                 310                 315                 320 
Leu Ser Phe Val Gln Thr Arg Gly Ser Val Pro Val Phe Trp Ser Gln
                325                 330                 335     
Val Gly Tyr Arg Tyr Asn Pro Arg Pro Arg Leu Asp Arg Ser Glu Lys
            340                 345                 350         
Glu Thr Val Ala Tyr Phe Cys Ala His Phe Glu Glu Gln Leu Asn Ile
        355                 360                 365             
Tyr Lys Lys Gln Val Ile Ile Asn Leu Val Asp Gln Ala Gly Arg Glu
    370                 375                 380                 
Lys Ile Ile Gly Asp Ala Tyr Leu Lys Gln Val Leu Leu Phe Asn Asn
385                 390                 395                 400 
Ser His Leu Thr Tyr Val Ser Phe Asp Phe His Glu His Cys Arg Gly
                405                 410                 415     
Met Lys Phe Glu Asn Val Gln Thr Leu Thr Asp Ala Ile Tyr Asp Ile
            420                 425                 430         
Ile Leu Asp Met Lys Trp Cys Trp Val Asp Glu Ala Gly Val Ile Cys
        435                 440                 445             
Lys Gln Glu Gly Ile Phe Arg Val Asn Cys Met Asp Cys Leu Asp Arg
    450                 455                 460                 
Thr Asn Val Val Gln Ala Ala Ile Ala Arg Val Val Met Glu Gln Gln
465                 470                 475                 480 
Leu Lys Lys Leu Gly Val Met Pro Pro Glu Gln Pro Leu Pro Val Lys
                485                 490                 495     
Cys Asn Arg Ile Tyr Gln Ile Met Trp Ala Asn Asn Gly Asp Ser Ile
            500                 505                 510         
Ser Arg Gln Tyr Ala Gly Thr Ala Ala Leu Lys Gly Asp Phe Thr Arg
        515                 520                 525             
Thr Gly Glu Arg Lys Leu Ala Gly Val Met Lys Asp Gly Val Asn Ser
    530                 535                 540                 
Ala Asn Arg Tyr Tyr Leu Asn Arg Phe Lys Asp Ala Tyr Arg Gln Ala
545                 550                 555                 560 
Val Ile Asp Leu Met Gln Gly Ile Pro Val Thr Glu Asp Leu Tyr Ser
                565                 570                 575     
Ile Phe Thr Lys Glu Lys Glu His Glu Ala Leu His Lys Glu Asn Gln
            580                 585                 590         
Arg Ser His Gln Glu Leu Ile Ser Gln Leu Leu Gln Ser Tyr Met Lys
        595                 600                 605             
Leu Leu Leu Pro Asp Asp Glu Lys Phe His Gly Gly Trp Ala Leu Ile
    610                 615                 620                 
Asp Cys Asp Pro Ser Leu Ile Asp Ala Thr His Arg Asp Val Asp Val
625                 630                 635                 640 
Leu Leu Leu Leu Ser Asn Ser Ala Tyr Tyr Val Ala Tyr Tyr Asp Asp
                645                 650                 655     
Glu Val Asp Lys Val Asn Gln Tyr Gln Arg Leu Ser Leu Glu Asn Leu
            660                 665                 670         
Glu Lys Ile Glu Ile Gly Pro Glu Pro Thr Leu Phe Gly Lys Pro Lys
        675                 680                 685             
Phe Ser Cys Met Arg Leu His Tyr Arg Tyr Lys Glu Ala Ser Gly Tyr
    690                 695                 700                 
Phe His Thr Leu Arg Ala Val Met Arg Asn Pro Glu Glu Asp Gly Lys
705                 710                 715                 720 
Asp Thr Leu Gln Cys Ile Ala Glu Met Leu Gln Ile Thr Lys Gln Ala
                725                 730                 735     
Met Gly Ser Asp Leu Pro Ile Ile Glu Lys Lys Leu Glu Arg Lys Ser
            740                 745                 750         
Ser Lys Pro His Glu Asp Ile Ile Gly Ile Arg Ser Gln Asn Gln Gly
        755                 760                 765             
Ser Leu Ala Gln Gly Lys Asn Phe Leu Met Ser Lys Phe Ser Ser Leu
    770                 775                 780                 
Asn Gln Lys Val Lys Gln Thr Lys Ser Asn Val Asn Ile Gly Asn Leu
785                 790                 795                 800 
Arg Lys Leu Gly Asn Phe Thr Lys Pro Glu Met Lys Val Asn Phe Leu
                805                 810                 815     
Lys Pro Asn Leu Lys Val Asn Leu Trp Lys Ser Asp Ser Ser Leu Glu
            820                 825                 830         
Thr Met Glu Asn Thr Gly Val Met Asp Lys Val Gln Ala Glu Ser Asp
        835                 840                 845             
Gly Asp Met Ser Ser Asp Asn Asp Ser Tyr His Ser Asp Glu Phe Leu
    850                 855                 860                 
Thr Asn Ser Lys Ser Asp Glu Asp Arg Gln Leu Ala Asn Ser Leu Glu
865                 870                 875                 880 
Ser Val Gly Pro Ile Asp Tyr Val Leu Pro Ser Cys Gly Ile Ile Ala
                885                 890                 895     
Ser Ala Pro Arg Leu Gly Ser Arg Ser Gln Ser Leu Ser Ser Thr Asp
            900                 905                 910         
Ser Ser Val His Ala Pro Ser Glu Ile Thr Val Ala His Gly Ser Gly
        915                 920                 925             
Leu Gly Lys Gly Gln Glu Ser Pro Leu Lys Lys Ser Pro Ser Ala Gly
    930                 935                 940                 
Asp Val His Ile Leu Thr Gly Phe Ala Lys Pro Met Asp Ile Tyr Cys
945                 950                 955                 960 
His Arg Phe Val Gln Asp Ala Gln Asn Lys Val Thr His Leu Ser Glu
                965                 970                 975     
Thr Arg Ser Val Ser Gln Gln Ala Ser Gln Glu Arg Asn Gln Met Thr
            980                 985                 990         
Asn Gln Val Ser Asn Glu Thr Gln Ser Glu Ser Thr Glu Gln Thr Pro
        995                 1000                1005            
Ser Arg Pro Ser Gln Leu Asp Val Ser Leu Ser Ala Thr Gly Pro Gln
    1010                1015                1020                
Phe Leu Ser Val Glu Pro Ala His Ser Val Ala Ser Gln Lys Thr Pro
1025                1030                1035                1040
Thr Ser Ala Ser Ser Met Leu Glu Leu Glu Thr Gly Leu His Val Thr
                1045                1050                1055    
Pro Ser Pro Ser Glu Ser Ser Ser Ser Arg Ala Val Ser Pro Phe Ala
            1060                1065                1070        
Lys Ile Arg Ser Ser Met Val Gln Val Ala Ser Ile Thr Gln Ala Gly
        1075                1080                1085            
Leu Thr His Gly Ile Asn Phe Ala Val Ser Lys Val Gln Lys Ser Pro
    1090                1095                1100                
Pro Glu Pro Glu Ile Ile Asn Gln Val Gln Gln Asn Glu Leu Lys Lys
1105                1110                1115                1120
Met Phe Ile Gln Cys Gln Thr Arg Ile Ile Gln Ile
                1125                1130        


<210> 8074
<211> 2063
<212> PRT
<213> Homo sapiens

<400> 8074
Met Val Leu Asp Asp Leu Pro Asn Leu Glu Asp Ile Tyr Thr Ser Leu
 1               5                  10                  15      
Cys Ser Ser Thr Met Glu Asp Ser Glu Met Asp Phe Asp Ser Gly Leu
            20                  25                  30          
Glu Asp Asp Asp Thr Lys Ser Asp Ser Ile Leu Glu Asp Ser Thr Ile
        35                  40                  45              
Phe Val Ala Phe Lys Gly Asn Ile Asp Asp Lys Asp Phe Lys Trp Lys
    50                  55                  60                  
Leu Asp Ala Ile Leu Lys Asn Val Pro Asn Leu Leu His Met Glu Ser
65                  70                  75                  80  
Ser Lys Leu Lys Val Gln Lys Val Glu Pro Trp Asn Ser Val Arg Val
                85                  90                  95      
Thr Phe Asn Ile Pro Arg Glu Ala Ala Glu Arg Leu Arg Ile Leu Ala
            100                 105                 110         
Gln Ser Asn Asn Gln Gln Leu Arg Asp Leu Gly Ile Leu Ser Val Gln
        115                 120                 125             
Ile Glu Gly Glu Gly Ala Ile Asn Leu Ala Leu Ala Gln Asn Arg Ser
    130                 135                 140                 
Gln Asp Val Arg Met Asn Gly Pro Met Gly Ala Gly Asn Ser Val Arg
145                 150                 155                 160 
Met Glu Ala Gly Phe Pro Met Ala Ser Gly Pro Gly Ile Ile Arg Met
                165                 170                 175     
Asn Asn Pro Ala Thr Val Met Ile Pro Pro Gly Gly Asn Val Ser Ser
            180                 185                 190         
Ser Met Met Ala Pro Gly Pro Asn Pro Glu Leu Gln Pro Arg Thr Pro
        195                 200                 205             
Arg Pro Ala Ser Gln Ser Asp Ala Met Asp Pro Leu Leu Ser Gly Leu
    210                 215                 220                 
His Ile Gln Gln Gln Ser His Pro Ser Gly Ser Leu Ala Pro Pro His
225                 230                 235                 240 
His Pro Met Gln Pro Val Ser Val Asn Arg Gln Met Asn Pro Ala Asn
                245                 250                 255     
Phe Pro Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            260                 265                 270         
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gln Ala
        275                 280                 285             
Arg Pro Pro Gln Gln His Gln Gln Gln Gln Pro Gln Gly Ile Arg Pro
    290                 295                 300                 
Gln Phe Thr Ala Pro Thr Gln Val Pro Val Pro Pro Gly Trp Asn Gln
305                 310                 315                 320 
Leu Pro Ser Gly Ala Leu Gln Pro Pro Pro Ala Gln Gly Ser Leu Gly
                325                 330                 335     
Thr Met Thr Ala Asn Gln Gly Trp Lys Lys Ala Pro Leu Pro Gly Pro
            340                 345                 350         
Met Gln Gln Gln Leu Gln Ala Arg Pro Ser Leu Ala Thr Val Gln Thr
        355                 360                 365             
Pro Ser His Pro Pro Pro Pro Tyr Pro Phe Gly Ser Gln Gln Ala Ser
    370                 375                 380                 
Gln Ala His Thr Asn Phe Pro Gln Met Ser Asn Pro Gly Gln Phe Thr
385                 390                 395                 400 
Ala Pro Gln Met Lys Ser Leu Gln Gly Gly Pro Ser Arg Val Pro Thr
                405                 410                 415     
Pro Leu Gln Gln Pro His Leu Thr Asn Lys Ser Pro Ala Ser Ser Pro
            420                 425                 430         
Ser Ser Phe Gln Gln Gly Ser Pro Ala Ser Ser Pro Thr Val Asn Gln
        435                 440                 445             
Thr Gln Gln Gln Met Gly Pro Arg Pro Pro Gln Asn Asn Pro Leu Pro
    450                 455                 460                 
Gln Gly Phe Gln Gln Pro Val Ser Ser Pro Gly Arg Asn Pro Met Val
465                 470                 475                 480 
Gln Gln Gly Asn Val Pro Pro Asn Phe Met Val Met Gln Gln Gln Pro
                485                 490                 495     
Pro Asn Gln Gly Pro Gln Ser Leu His Pro Gly Leu Gly Gly Met Pro
            500                 505                 510         
Lys Arg Leu Pro Pro Gly Phe Ser Ala Gly Gln Ala Asn Pro Asn Phe
        515                 520                 525             
Met Gln Gly Gln Val Pro Ser Thr Thr Ala Thr Thr Pro Gly Asn Ser
    530                 535                 540                 
Gly Ala Pro Gln Leu Gln Ala Asn Gln Asn Val Gln His Ala Gly Gly
545                 550                 555                 560 
Gln Gly Ala Gly Pro Pro Gln Asn Gln Met Gln Val Ser His Gly Pro
                565                 570                 575     
Pro Asn Met Met Gln Pro Ser Leu Met Gly Ile His Gly Asn Met Asn
            580                 585                 590         
Asn Gln Gln Ala Gly Thr Ser Gly Val Pro Gln Val Asn Leu Ser Asn
        595                 600                 605             
Met Gln Gly Gln Pro Gln Gln Gly Pro Pro Ser Gln Leu Met Gly Met
    610                 615                 620                 
His Gln Gln Ile Val Pro Ser Gln Gly Gln Met Val Gln Gln Gln Gly
625                 630                 635                 640 
Thr Leu Asn Pro Gln Asn Pro Met Ile Leu Ser Arg Ala Gln Leu Met
                645                 650                 655     
Pro Gln Gly Gln Met Met Val Asn Pro Pro Ser Gln Asn Leu Gly Pro
            660                 665                 670         
Ser Pro Gln Arg Met Thr Pro Pro Lys Gln Met Leu Ser Gln Gln Gly
        675                 680                 685             
Pro Gln Met Met Ala Pro His Asn Gln Met Met Gly Pro Gln Gly Gln
    690                 695                 700                 
Val Leu Leu Gln Gln Asn Pro Met Ile Glu Gln Ile Met Thr Asn Gln
705                 710                 715                 720 
Met Gln Gly Asn Lys Gln Gln Phe Asn Thr Gln Asn Gln Ser Asn Val
                725                 730                 735     
Met Pro Gly Pro Ala Gln Ile Met Arg Gly Pro Thr Pro Asn Met Gln
            740                 745                 750         
Gly Asn Met Val Gln Phe Thr Gly Gln Met Ser Gly Gln Met Leu Pro
        755                 760                 765             
Gln Gln Gly Pro Val Asn Asn Ser Pro Ser Gln Val Met Gly Ile Gln
    770                 775                 780                 
Gly Gln Val Leu Arg Pro Pro Gly Pro Ser Pro His Met Ala Gln Gln
785                 790                 795                 800 
His Gly Asp Pro Ala Thr Thr Ala Asn Asn Asp Val Ser Leu Ser Gln
                805                 810                 815     
Met Met Pro Asp Val Ser Ile Gln Gln Thr Asn Met Val Pro Pro His
            820                 825                 830         
Val Gln Ala Met Gln Gly Asn Ser Ala Ser Gly Asn His Phe Ser Gly
        835                 840                 845             
His Gly Met Ser Phe Asn Ala Pro Phe Ser Gly Ala Pro Asn Gly Asn
    850                 855                 860                 
Gln Met Ser Cys Gly Gln Asn Pro Gly Phe Pro Val Asn Lys Asp Val
865                 870                 875                 880 
Thr Leu Thr Ser Pro Leu Leu Val Asn Leu Leu Gln Ser Asp Ile Ser
                885                 890                 895     
Ala Gly His Phe Gly Val Asn Asn Lys Gln Asn Asn Thr Asn Ala Asn
            900                 905                 910         
Lys Pro Lys Lys Lys Lys Pro Pro Arg Lys Lys Lys Asn Ser Gln Gln
        915                 920                 925             
Asp Leu Asn Thr Pro Asp Thr Arg Pro Ala Gly Leu Glu Glu Ala Asp
    930                 935                 940                 
Gln Pro Pro Leu Pro Gly Glu Gln Gly Ile Ser Leu Asp Asn Ser Gly
945                 950                 955                 960 
Pro Lys Leu Pro Glu Phe Ser Asn Arg Pro Pro Gly Tyr Pro Ser Gln
                965                 970                 975     
Pro Val Glu Gln Arg Pro Leu Gln Gln Met Pro Pro Gln Leu Met Gln
            980                 985                 990         
His Val Ala Pro Pro Pro Gln Pro Pro Gln Gln Gln Pro Gln Pro Gln
        995                 1000                1005            
Leu Pro Gln Gln Gln Gln Pro Pro Pro Pro Ser Gln Pro Gln Ser Gln
    1010                1015                1020                
Gln Gln Gln Gln Gln Gln Gln Gln Met Met Met Met Leu Met Met Gln
1025                1030                1035                1040
Gln Asp Pro Lys Ser Val Arg Leu Pro Val Ser Gln Asn Val His Pro
                1045                1050                1055    
Pro Arg Gly Pro Leu Asn Pro Asp Ser Gln Arg Met Pro Met Gln Gln
            1060                1065                1070        
Ser Gly Ser Val Pro Val Met Val Ser Leu Gln Gly Pro Ala Ser Val
        1075                1080                1085            
Pro Pro Ser Pro Asp Lys Gln Arg Met Pro Met Pro Val Asn Thr Pro
    1090                1095                1100                
Leu Gly Ser Asn Ser Arg Lys Met Val Tyr Gln Glu Ser Pro Gln Asn
1105                1110                1115                1120
Pro Ser Ser Ser Pro Leu Ala Glu Met Ala Ser Leu Pro Glu Ala Ser
                1125                1130                1135    
Gly Ser Glu Ala Pro Ser Val Pro Gly Gly Pro Asn Asn Met Pro Ser
            1140                1145                1150        
His Val Val Leu Pro Gln Asn Gln Leu Met Met Thr Gly Pro Lys Pro
        1155                1160                1165            
Gly Pro Ser Pro Leu Ser Ala Thr Gln Gly Ala Thr Pro Gln Gln Pro
    1170                1175                1180                
Pro Val Asn Ser Leu Pro Ser Ser His Gly His His Phe Pro Asn Val
1185                1190                1195                1200
Ala Ala Pro Thr Gln Thr Ser Arg Pro Lys Thr Pro Asn Arg Ala Ser
                1205                1210                1215    
Pro Arg Pro Tyr Tyr Pro Gln Thr Pro Asn Asn Arg Pro Pro Ser Thr
            1220                1225                1230        
Glu Pro Ser Glu Ile Ser Leu Ser Pro Glu Arg Leu Asn Ala Ser Ile
        1235                1240                1245            
Ala Gly Leu Phe Pro Pro Gln Ile Asn Ile Pro Leu Pro Pro Arg Pro
    1250                1255                1260                
Asn Leu Asn Arg Gly Phe Asp Gln Gln Gly Leu Asn Pro Thr Thr Leu
1265                1270                1275                1280
Lys Ala Ile Gly Gln Ala Pro Ser Asn Leu Thr Met Asn Pro Ser Asn
                1285                1290                1295    
Phe Ala Thr Pro Gln Thr His Lys Leu Asp Ser Val Val Val Asn Ser
            1300                1305                1310        
Gly Lys Gln Ser Asn Ser Gly Ala Thr Lys Arg Ala Ser Pro Ser Asn
        1315                1320                1325            
Ser Arg Arg Ser Ser Pro Gly Ser Ser Arg Lys Thr Thr Pro Ser Pro
    1330                1335                1340                
Gly Arg Gln Asn Ser Lys Ala Pro Lys Leu Thr Leu Ala Ser Gln Thr
1345                1350                1355                1360
Asn Ala Ala Leu Leu Gln Asn Val Glu Leu Pro Arg Asn Val Leu Val
                1365                1370                1375    
Ser Pro Thr Pro Leu Ala Asn Pro Pro Val Pro Gly Ser Phe Pro Asn
            1380                1385                1390        
Asn Ser Gly Leu Asn Pro Gln Asn Ser Thr Val Ser Val Ala Ala Val
        1395                1400                1405            
Gly Gly Val Val Glu Asp Asn Lys Glu Ser Leu Asn Val Pro Gln Asp
    1410                1415                1420                
Ser Asp Cys Gln Asn Ser Gln Ser Arg Lys Glu Gln Val Asn Ile Glu
1425                1430                1435                1440
Leu Lys Ala Val Pro Ala Gln Glu Val Lys Met Val Val Pro Glu Asp
                1445                1450                1455    
Gln Ser Lys Lys Asp Gly Gln Pro Ser Asp Pro Asn Lys Leu Pro Ser
            1460                1465                1470        
Val Glu Glu Asn Lys Asn Leu Val Ser Pro Ala Met Arg Glu Ala Pro
        1475                1480                1485            
Thr Ser Leu Ser Gln Leu Leu Asp Asn Ser Gly Ala Pro Asn Val Thr
    1490                1495                1500                
Ile Lys Pro Pro Gly Leu Thr Asp Leu Glu Val Thr Pro Pro Val Val
1505                1510                1515                1520
Ser Gly Glu Asp Leu Lys Lys Ala Ser Val Ile Pro Thr Leu Gln Asp
                1525                1530                1535    
Leu Ser Ser Ser Lys Glu Pro Ser Asn Ser Leu Asn Leu Pro His Ser
            1540                1545                1550        
Asn Glu Leu Cys Ser Ser Leu Val His Pro Glu Leu Ser Glu Val Ser
        1555                1560                1565            
Ser Asn Val Ala Pro Ser Ile Pro Pro Val Met Ser Arg Pro Val Ser
    1570                1575                1580                
Ser Ser Ser Ile Ser Thr Pro Leu Pro Pro Asn Gln Ile Thr Val Phe
1585                1590                1595                1600
Val Thr Ser Asn Pro Ile Thr Thr Ser Ala Asn Thr Ser Ala Ala Leu
                1605                1610                1615    
Pro Thr His Leu Gln Ser Ala Leu Met Ser Thr Val Val Thr Met Pro
            1620                1625                1630        
Asn Ala Gly Ser Lys Val Met Val Ser Glu Gly Gln Ser Ala Ala Gln
        1635                1640                1645            
Ser Asn Ala Arg Pro Gln Phe Ile Thr Pro Val Phe Ile Asn Ser Ser
    1650                1655                1660                
Ser Ile Ile Gln Val Met Lys Gly Ser Gln Pro Ser Thr Ile Pro Ala
1665                1670                1675                1680
Ala Pro Leu Thr Thr Asn Ser Gly Leu Met Pro Pro Ser Val Ala Val
                1685                1690                1695    
Val Gly Pro Leu His Ile Pro Gln Asn Ile Lys Phe Ser Ser Ala Pro
            1700                1705                1710        
Val Pro Pro Asn Ala Leu Ser Ser Ser Pro Ala Pro Asn Ile Gln Thr
        1715                1720                1725            
Gly Arg Pro Leu Val Leu Ser Ser Arg Ala Thr Pro Val Gln Leu Pro
    1730                1735                1740                
Ser Pro Pro Cys Thr Ser Ser Pro Val Val Pro Ser His Pro Pro Val
1745                1750                1755                1760
Gln Gln Val Lys Glu Leu Asn Pro Asp Glu Ala Ser Pro Gln Val Asn
                1765                1770                1775    
Thr Ser Ala Asp Gln Asn Thr Leu Pro Ser Ser Gln Ser Thr Thr Met
            1780                1785                1790        
Val Ser Pro Leu Leu Thr Asn Ser Pro Gly Ser Ser Gly Asn Arg Arg
        1795                1800                1805            
Ser Pro Val Ser Ser Ser Lys Gly Lys Gly Lys Val Asp Lys Ile Gly
    1810                1815                1820                
Gln Ile Leu Leu Thr Lys Ala Cys Lys Lys Val Thr Gly Ser Leu Glu
1825                1830                1835                1840
Lys Gly Glu Glu Gln Tyr Gly Ala Asp Gly Glu Thr Glu Gly Gln Gly
                1845                1850                1855    
Leu Asp Thr Thr Ala Pro Gly Leu Met Gly Thr Glu Gln Leu Ser Thr
            1860                1865                1870        
Glu Leu Asp Ser Lys Thr Pro Thr Pro Pro Ala Pro Thr Leu Leu Lys
        1875                1880                1885            
Met Thr Ser Ser Pro Val Gly Pro Gly Thr Ala Ser Ala Gly Pro Ser
    1890                1895                1900                
Leu Pro Gly Gly Ala Leu Pro Thr Ser Val Arg Ser Ile Val Thr Thr
1905                1910                1915                1920
Leu Val Pro Ser Glu Leu Ile Ser Ala Val Pro Thr Thr Lys Ser Asn
                1925                1930                1935    
His Gly Gly Ile Ala Ser Glu Ser Leu Ala Gly Gly Leu Val Glu Glu
            1940                1945                1950        
Lys Val Gly Ser His Pro Glu Leu Leu Pro Ser Ile Ala Pro Ser Gln
        1955                1960                1965            
Asn Leu Val Ser Lys Glu Thr Ser Thr Thr Ala Leu Gln Ala Ser Val
    1970                1975                1980                
Ala Arg Pro Glu Leu Glu Val Asn Ala Ala Ile Val Ser Gly Gln Ser
1985                1990                1995                2000
Ser Glu Pro Lys Glu Ile Val Glu Lys Ser Lys Ile Pro Gly Arg Arg
                2005                2010                2015    
Asn Ser Arg Thr Glu Glu Pro Thr Val Ala Ser Glu Ser Val Glu Asn
            2020                2025                2030        
Gly His Arg Lys Arg Ser Ser Arg Pro Ala Ser Ala Ser Ser Ser Thr
        2035                2040                2045            
Lys Asp Ile Thr Ser Ala Val Gln Ser Lys Arg Arg Lys Ser Lys
    2050                2055                2060            


<210> 8075
<211> 292
<212> PRT
<213> Homo sapiens

<400> 8075
Met Val Asp Ala Gly Leu Arg Arg Val Val Pro Ser His Leu Cys Pro
 1               5                  10                  15      
Leu Val Phe Gly Phe Leu Cys Asp Asn Gln Leu Leu Glu Met Ala Lys
            20                  25                  30          
Lys Phe Ala Lys Val Thr Gly Thr Thr Gln Gln Asp Ala Asn Ala Phe
        35                  40                  45              
Ser Leu Leu Asp Ile Tyr Ser Phe Trp Leu Lys Ser Val Lys Ala Pro
    50                  55                  60                  
Lys Arg Lys Leu Gln Ala Asn Gly Pro Val Thr Lys Lys Ala Lys Lys
65                  70                  75                  80  
Lys Thr Ser Ser Cys Asp Ser Ser Glu Asp Ser Glu Asp Gly Asp Ala
                85                  90                  95      
Gln Gly Pro Pro Ala Lys Lys Ala Ala Val Pro Ala Met Gly Ala Ser
            100                 105                 110         
Leu Pro Gln His Pro Gly Lys Ala Val Ala Lys Ala Ser Glu Ala Ala
        115                 120                 125             
Val Asn Asn Leu Val Thr Val Arg Arg Arg Arg His Lys Glu Lys Ala
    130                 135                 140                 
Cys Pro Asp Gly Val Lys Pro Gln Ala Lys Ala Ala Lys Ala Pro Pro
145                 150                 155                 160 
Lys Lys Val Lys Lys Ser Asp Ser Asp Ser Asp Ser Ser Ser Glu Asp
                165                 170                 175     
Glu Ala His His Arg Thr Arg Arg Gln Arg Leu His Leu Trp Gln Leu
            180                 185                 190         
Thr Trp Ala Lys Ala Ile Pro Gly Thr Pro Ala Pro Ala Ala Pro Lys
        195                 200                 205             
Val Ala Asn Lys Lys Gly Arg Ala Ala Ala Ile Pro Lys Lys Thr Ile
    210                 215                 220                 
Pro Lys Lys Gln Val Met Ala Lys Leu Pro Val Lys Ala Ala Ala Asn
225                 230                 235                 240 
Pro Thr Tyr Ser Val Pro Arg Pro Pro Ala Pro Gln Ser Lys Lys Ser
                245                 250                 255     
Val Gly Thr Gln Thr Pro Lys Lys Thr Ala Lys Lys Lys Gln Pro Val
            260                 265                 270         
Glu Ser Ser Glu Asp Ser Thr Asp Asp Ser Asn Ser Ser Ser Gly Glu
        275                 280                 285             
Glu Glu Arg Pro
    290         


<210> 8076
<211> 291
<212> PRT
<213> Homo sapiens

<400> 8076
Met Asp Pro Ser Leu Leu Arg Glu Arg Glu Leu Phe Lys Lys Arg Ala
 1               5                  10                  15      
Leu Ser Thr Pro Val Val Glu Lys Arg Ser Ala Ser Ser Glu Ser Ser
            20                  25                  30          
Ser Ser Ser Ser Lys Lys Lys Lys Thr Lys Val Glu His Gly Gly Ser
        35                  40                  45              
Ser Gly Ser Lys Gln Asn Ser Asp His Ser Asn Gly Ser Phe Asn Leu
    50                  55                  60                  
Lys Ala Leu Ser Gly Ser Ser Gly Tyr Lys Phe Gly Val Leu Ala Lys
65                  70                  75                  80  
Ile Val Asn Tyr Met Lys Thr Arg His Gln Arg Gly Asp Thr His Pro
                85                  90                  95      
Leu Thr Leu Asp Glu Ile Leu Asp Glu Thr Gln His Leu Asp Ile Gly
            100                 105                 110         
Leu Lys Gln Lys Gln Trp Leu Met Thr Glu Ala Leu Val Asn Asn Pro
        115                 120                 125             
Lys Ile Glu Val Ile Asp Gly Lys Tyr Ala Phe Lys Pro Lys Tyr Asn
    130                 135                 140                 
Val Arg Asp Lys Lys Ala Leu Leu Arg Leu Leu Asp Gln His Asp Gln
145                 150                 155                 160 
Arg Gly Leu Gly Gly Ile Leu Leu Glu Asp Ile Glu Glu Ala Leu Pro
                165                 170                 175     
Asn Ser Gln Lys Ala Val Lys Ala Leu Gly Asp Gln Ile Leu Phe Val
            180                 185                 190         
Asn Arg Pro Asp Lys Lys Lys Ile Leu Phe Phe Asn Asp Lys Ser Cys
        195                 200                 205             
Gln Phe Ser Val Asp Glu Glu Phe Gln Lys Leu Trp Arg Ser Val Thr
    210                 215                 220                 
Val Asp Ser Met Asp Glu Glu Lys Ile Glu Glu Tyr Leu Lys Arg Gln
225                 230                 235                 240 
Gly Ile Ser Ser Met Gln Glu Ser Gly Pro Lys Lys Val Ala Pro Ile
                245                 250                 255     
Gln Arg Arg Lys Lys Pro Ala Ser Gln Lys Lys Arg Arg Phe Lys Thr
            260                 265                 270         
His Asn Glu His Leu Ala Gly Val Leu Lys Asp Tyr Ser Asp Ile Thr
        275                 280                 285             
Ser Ser Lys
    290     


<210> 8077
<211> 486
<212> PRT
<213> Homo sapiens

<400> 8077
Met Ser Ser Ser Ser Pro Pro Ala Gly Ala Ala Ser Ala Ala Ile Ser
 1               5                  10                  15      
Ala Ser Glu Lys Val Asp Gly Phe Thr Arg Lys Ser Val Arg Lys Ala
            20                  25                  30          
Gln Arg Gln Lys Arg Ser Gln Gly Ser Ser Gln Phe Arg Ser Gln Gly
        35                  40                  45              
Ser Gln Ala Glu Leu His Pro Leu Pro Gln Leu Lys Asp Ala Thr Ser
    50                  55                  60                  
Asn Glu Gln Gln Glu Leu Phe Cys Gln Lys Leu Gln Gln Cys Cys Ile
65                  70                  75                  80  
Leu Phe Asp Phe Met Asp Ser Val Ser Asp Leu Lys Ser Lys Glu Ile
                85                  90                  95      
Lys Arg Ala Thr Leu Asn Glu Leu Val Glu Tyr Val Ser Thr Asn Arg
            100                 105                 110         
Gly Val Ile Val Glu Ser Ala Tyr Ser Asp Ile Val Lys Met Ile Ser
        115                 120                 125             
Ala Asn Ile Phe Arg Thr Leu Pro Pro Ser Asp Asn Pro Asp Phe Asp
    130                 135                 140                 
Pro Glu Glu Asp Glu Pro Thr Leu Glu Ala Ser Trp Pro His Ile Gln
145                 150                 155                 160 
Leu Val Tyr Glu Phe Phe Leu Arg Phe Leu Glu Ser Pro Asp Phe Gln
                165                 170                 175     
Pro Ser Ile Ala Lys Arg Tyr Ile Asp Gln Lys Phe Val Gln Gln Leu
            180                 185                 190         
Leu Glu Leu Phe Asp Ser Glu Asp Pro Arg Glu Arg Asp Phe Leu Lys
        195                 200                 205             
Thr Val Leu His Arg Ile Tyr Gly Lys Phe Leu Gly Leu Arg Ala Phe
    210                 215                 220                 
Ile Arg Lys Gln Ile Asn Asn Ile Phe Leu Arg Phe Ile Tyr Glu Thr
225                 230                 235                 240 
Glu His Phe Asn Gly Val Ala Glu Leu Leu Glu Ile Leu Gly Ser Ile
                245                 250                 255     
Ile Asn Gly Phe Ala Leu Pro Leu Lys Ala Glu His Lys Gln Phe Leu
            260                 265                 270         
Met Lys Val Leu Ile Pro Met His Thr Ala Lys Gly Leu Ala Leu Phe
        275                 280                 285             
His Ala Gln Leu Ala Tyr Cys Val Val Gln Phe Leu Glu Lys Asp Thr
    290                 295                 300                 
Thr Leu Thr Glu Pro Val Ile Arg Gly Leu Leu Lys Phe Trp Pro Lys
305                 310                 315                 320 
Thr Cys Ser Gln Lys Glu Val Met Phe Leu Gly Glu Ile Glu Glu Ile
                325                 330                 335     
Leu Asp Val Ile Glu Pro Thr Gln Phe Lys Lys Ile Glu Glu Pro Leu
            340                 345                 350         
Phe Lys Gln Ile Ser Lys Cys Val Ser Ser Ser His Phe Gln Val Ala
        355                 360                 365             
Glu Arg Ala Leu Tyr Phe Trp Asn Asn Glu Tyr Ile Leu Ser Leu Ile
    370                 375                 380                 
Glu Glu Asn Ile Asp Lys Ile Leu Pro Ile Met Phe Ala Ser Leu Tyr
385                 390                 395                 400 
Lys Ile Ser Lys Glu His Trp Asn Pro Thr Ile Val Ala Leu Val Tyr
                405                 410                 415     
Asn Val Leu Lys Thr Leu Met Glu Met Asn Gly Lys Leu Phe Asp Asp
            420                 425                 430         
Leu Thr Ser Ser Tyr Lys Ala Glu Arg Gln Arg Glu Lys Lys Lys Glu
        435                 440                 445             
Leu Glu Arg Glu Glu Leu Trp Lys Lys Leu Glu Glu Leu Lys Leu Lys
    450                 455                 460                 
Lys Ala Leu Glu Lys Gln Asn Ser Ala Tyr Asn Met His Ser Ile Leu
465                 470                 475                 480 
Ser Asn Thr Ser Ala Glu
                485     


<210> 8078
<211> 302
<212> PRT
<213> Homo sapiens

<400> 8078
Met Ala Leu His Glu Met Glu Asp Phe Thr Phe Asp Gly Thr Lys Arg
 1               5                  10                  15      
Leu Ser Val Asn Tyr Val Lys Gly Ile Leu Gln Pro Thr Asp Thr Cys
            20                  25                  30          
Asp Ile Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu
        35                  40                  45              
Leu Ile Ser Thr Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln Glu Ile
    50                  55                  60                  
Val Glu Leu Ile Gln Asn Glu Gly Asp Val Glu Lys Ser Lys Arg Ala
65                  70                  75                  80  
Pro Thr His Gln Arg Phe Pro Phe Leu Glu Met Lys Ile Pro Ser Leu
                85                  90                  95      
Gly Ser Gly Leu Glu Gln Ala His Ala Met Pro Ser Pro Arg Ile Leu
            100                 105                 110         
Lys Thr His Leu Pro Phe His Leu Leu Pro Pro Ser Leu Leu Glu Lys
        115                 120                 125             
Asn Cys Lys Ile Ile Tyr Val Ala Arg Asn Pro Lys Asp Asn Met Val
    130                 135                 140                 
Ser Tyr Tyr His Phe Gln Arg Met Asn Lys Ala Leu Pro Ala Pro Gly
145                 150                 155                 160 
Thr Trp Glu Glu Tyr Phe Glu Thr Phe Leu Ala Gly Lys Val Cys Trp
                165                 170                 175     
Gly Ser Trp His Glu His Val Lys Gly Trp Trp Glu Ala Lys Asp Lys
            180                 185                 190         
His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Met Lys Lys Asn Pro Lys
        195                 200                 205             
His Glu Ile Gln Lys Leu Ala Glu Phe Ile Gly Lys Lys Leu Asp Asp
    210                 215                 220                 
Lys Val Leu Asp Lys Ile Val His Tyr Thr Ser Phe Asp Val Met Lys
225                 230                 235                 240 
Gln Asn Pro Met Ala Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met Asp
                245                 250                 255     
His Ser Ile Ser Pro Phe Met Arg Lys Gly Ala Val Gly Asp Trp Lys
            260                 265                 270         
Lys His Phe Thr Val Ala Gln Asn Glu Arg Phe Asp Glu Asp Tyr Lys
        275                 280                 285             
Lys Lys Met Thr Asp Thr Arg Leu Thr Phe His Phe Gln Phe
    290                 295                 300         


<210> 8079
<211> 284
<212> PRT
<213> Homo sapiens

<400> 8079
Ile Met Glu Val Asp Gly Val Pro Thr Leu Ile Leu Ser Lys Glu Trp
 1               5                  10                  15      
Trp Glu Lys Val Cys Asn Phe Gln Ala Lys Pro Asp Asp Leu Ile Leu
            20                  25                  30          
Ala Thr Tyr Pro Lys Ser Gly Thr Thr Trp Ile Gln Glu Ile Val Asp
        35                  40                  45              
Met Ile Glu Gln Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile
    50                  55                  60                  
Gln His Arg His Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser
65                  70                  75                  80  
Gly Leu Glu Gln Ala His Ala Met Pro Ser Pro Arg Ile Leu Lys Thr
                85                  90                  95      
His Leu Pro Phe His Leu Leu Pro Pro Ser Leu Leu Glu Lys Asn Cys
            100                 105                 110         
Lys Ile Ile Tyr Val Ala Arg Asn Pro Lys Asp Asn Met Val Ser Tyr
        115                 120                 125             
Tyr His Phe Gln Arg Met Asn Lys Ala Leu Pro Ala Pro Gly Thr Trp
    130                 135                 140                 
Glu Glu Tyr Phe Glu Thr Phe Leu Ala Gly Lys Val Cys Trp Gly Ser
145                 150                 155                 160 
Trp His Glu His Val Lys Gly Trp Trp Glu Ala Lys Asp Lys His Arg
                165                 170                 175     
Ile Leu Tyr Leu Phe Tyr Glu Asp Met Lys Lys Asn Pro Lys His Glu
            180                 185                 190         
Ile Gln Lys Leu Ala Glu Phe Ile Gly Lys Lys Leu Asp Asp Lys Val
        195                 200                 205             
Leu Asp Lys Ile Val His Tyr Thr Ser Phe Asp Val Met Lys Gln Asn
    210                 215                 220                 
Pro Met Ala Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met Asp His Ser
225                 230                 235                 240 
Ile Ser Pro Phe Met Arg Lys Gly Ala Val Gly Asp Trp Lys Lys His
                245                 250                 255     
Phe Thr Val Ala Gln Asn Glu Arg Phe Asp Glu Asp Tyr Lys Lys Lys
            260                 265                 270         
Met Thr Asp Thr Arg Leu Thr Phe His Phe Gln Phe
        275                 280                 


<210> 8080
<211> 576
<212> PRT
<213> Homo sapiens

<400> 8080
Met Asp Asp Leu Lys Tyr Gly Val Tyr Pro Leu Lys Glu Ala Ser Gly
 1               5                  10                  15      
Cys Pro Gly Ala Glu Arg Asn Leu Leu Val Tyr Ser Tyr Phe Glu Lys
            20                  25                  30          
Glu Thr Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu
        35                  40                  45              
Trp Glu Cys Leu Asn Pro Ala Gln Gln Asn Leu Tyr Met Asn Val Met
    50                  55                  60                  
Leu Glu Asn Tyr Lys Asn Leu Val Phe Leu Gly Val Ala Val Ser Lys
65                  70                  75                  80  
Gln Asp Pro Val Thr Cys Leu Glu Gln Glu Lys Glu Pro Trp Asn Met
                85                  90                  95      
Lys Arg His Glu Met Val Asp Glu Pro Pro Ala Met Cys Ser Tyr Phe
            100                 105                 110         
Thr Lys Asp Leu Trp Pro Glu Gln Asp Ile Lys Asp Ser Phe Gln Gln
        115                 120                 125             
Val Ile Leu Arg Arg Tyr Gly Lys Cys Glu His Glu Asn Leu Gln Leu
    130                 135                 140                 
Arg Lys Gly Ser Ala Ser Val Asp Glu Tyr Lys Val His Lys Glu Gly
145                 150                 155                 160 
Tyr Asn Glu Leu Asn Gln Cys Leu Thr Thr Thr Gln Ser Lys Ile Phe
                165                 170                 175     
Pro Cys Asp Lys Tyr Val Lys Val Phe His Lys Phe Leu Asn Ala Asn
            180                 185                 190         
Arg His Lys Thr Arg His Thr Gly Lys Lys Pro Phe Lys Cys Lys Lys
        195                 200                 205             
Cys Gly Lys Ser Phe Cys Met Leu Leu His Leu Ser Gln His Lys Arg
    210                 215                 220                 
Ile His Ile Arg Glu Asn Ser Tyr Gln Cys Glu Glu Cys Gly Lys Ala
225                 230                 235                 240 
Phe Lys Trp Phe Ser Thr Leu Thr Arg His Lys Arg Ile His Thr Gly
                245                 250                 255     
Glu Lys Pro Phe Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln Ser
            260                 265                 270         
Ser Thr Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr
        275                 280                 285             
Arg Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser His Leu Thr
    290                 295                 300                 
Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
305                 310                 315                 320 
Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu Ser Thr His Lys Phe
                325                 330                 335     
Ile His Ala Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Asp Lys Ala
            340                 345                 350         
Phe Asn Arg Phe Ser Tyr Leu Thr Lys His Lys Ile Ile His Thr Gly
        355                 360                 365             
Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Asn Trp Ser
    370                 375                 380                 
Ser Thr Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr
385                 390                 395                 400 
Lys Cys Glu Val Cys Gly Lys Ala Phe Asn Glu Ser Ser Asn Leu Thr
                405                 410                 415     
Thr His Lys Met Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
            420                 425                 430         
Cys Gly Lys Ala Phe Asn Arg Ser Pro Gln Leu Thr Ala His Lys Ile
        435                 440                 445             
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
    450                 455                 460                 
Phe Ser Gln Ser Ser Ile Leu Thr Thr His Lys Arg Ile His Thr Gly
465                 470                 475                 480 
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser
                485                 490                 495     
Ser Asn Leu Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Ser Tyr
            500                 505                 510         
Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu Thr
        515                 520                 525             
Lys His Arg Lys Ile His Thr Arg Gln Lys Pro Tyr Asn Cys Glu Glu
    530                 535                 540                 
Cys Asp Asn Thr Phe Asn Gln Ser Ser Asn Leu Ile Lys Gln Asn Asn
545                 550                 555                 560 
Ser Tyr Trp Arg Glu Thr Leu Gln Met Ser Arg Met Trp Glu Ser Leu
                565                 570                 575     


<210> 8081
<211> 381
<212> PRT
<213> Homo sapiens

<400> 8081
Thr Lys Tyr Lys Glu Gly Ala Val Asp Ala Asp Met Gln Gly Cys Glu
 1               5                  10                  15      
Asp Met Lys Ala Asp Ile Met Phe Leu Val Asp Ser Ser Trp Ser Ile
            20                  25                  30          
Gly Asn Glu Asn Phe Arg Lys Met Lys Ile Phe Met Lys Asn Leu Leu
        35                  40                  45              
Thr Lys Ile Gln Ile Gly Ala Asp Lys Thr Gln Ile Gly Val Val Gln
    50                  55                  60                  
Phe Ser Asp Lys Thr Lys Glu Glu Phe Gln Leu Asn Arg Tyr Phe Thr
65                  70                  75                  80  
Gln Gln Glu Ile Ser Asp Ala Ile Asp Arg Met Asp Thr Gly Gly Asn
                85                  90                  95      
Thr Tyr Thr Ala Lys Ala Leu Lys His Ala Asn Ala Leu Phe Thr Glu
            100                 105                 110         
Glu His Gly Ser Arg Ile Lys Gln Asn Val Lys Gln Met Leu Ile Val
        115                 120                 125             
Ile Thr Asp Gly Glu Ser His Asp His Asp Gln Leu Asn Asp Thr Ala
    130                 135                 140                 
Leu Glu Leu Arg Asn Lys Gly Ile Thr Ile Phe Ala Val Gly Val Gly
145                 150                 155                 160 
Lys Ala Asn Gln Lys Glu Leu Glu Gly Met Ala Gly Asn Lys Asn Asn
                165                 170                 175     
Thr Ile Tyr Val Asp Asn Phe Asp Lys Leu Lys Asp Val Phe Thr Leu
            180                 185                 190         
Val Gln Glu Arg Met Cys Thr Glu Ala Pro Glu Ala Cys Lys Glu Met
        195                 200                 205             
Lys Ala Asp Ile Met Phe Leu Val Asp Ser Ser Gly Ser Ile Gly Pro
    210                 215                 220                 
Glu Asn Phe Ser Lys Met Lys Thr Phe Met Lys Asn Leu Val Ser Lys
225                 230                 235                 240 
Ser Gln Ile Gly Pro Asp Arg Val Gln Ile Gly Val Val Gln Phe Ser
                245                 250                 255     
Asp Ile Asn Lys Glu Glu Phe Gln Leu Asn Arg Phe Met Ser Gln Ser
            260                 265                 270         
Asp Ile Ser Asn Ala Ile Asp Gln Met Ala His Ile Gly Gln Thr Thr
        275                 280                 285             
Leu Thr Gly Ser Ala Leu Ser Phe Val Ser Gln Tyr Phe Ser Pro Thr
    290                 295                 300                 
Lys Gly Ala Arg Pro Asn Ile Arg Lys Phe Leu Ile Leu Ile Thr Asp
305                 310                 315                 320 
Gly Glu Ala Gln Asp Ile Val Lys Glu Pro Ala Val Val Leu Arg Gln
                325                 330                 335     
Glu Gly Val Ile Ile Tyr Ser Val Gly Val Phe Gly Ser Asn Val Thr
            340                 345                 350         
Gln Leu Glu Glu Ile Ser Gly Arg Pro Glu Met Val Phe Tyr Val Glu
        355                 360                 365             
Asn Phe Asp Ile Leu Gln Arg Ile Glu Asp Asp Leu Val
    370                 375                 380     


<210> 8082
<211> 386
<212> PRT
<213> Homo sapiens

<400> 8082
Met Asn Ile Met Asp Phe Asn Val Lys Lys Leu Ala Ala Asp Ala Gly
 1               5                  10                  15      
Thr Phe Leu Ser Arg Ala Val Gln Phe Thr Glu Glu Lys Leu Gly Gln
            20                  25                  30          
Ala Glu Lys Thr Glu Leu Asp Ala His Leu Glu Asn Leu Leu Ser Lys
        35                  40                  45              
Ala Glu Cys Thr Lys Ile Trp Thr Glu Lys Ile Met Lys Gln Thr Glu
    50                  55                  60                  
Val Leu Leu Gln Pro Asn Pro Asn Ala Arg Ile Glu Glu Phe Val Tyr
65                  70                  75                  80  
Glu Lys Leu Asp Arg Lys Ala Pro Ser Arg Ile Asn Asn Pro Glu Leu
                85                  90                  95      
Leu Gly Gln Tyr Met Ile Asp Ala Gly Thr Glu Phe Gly Pro Gly Thr
            100                 105                 110         
Ala Tyr Gly Asn Ala Leu Ile Lys Cys Gly Glu Thr Gln Lys Arg Ile
        115                 120                 125             
Gly Thr Ala Asp Arg Glu Leu Ile Gln Thr Ser Ala Leu Asn Phe Leu
    130                 135                 140                 
Thr Pro Leu Arg Asn Phe Ile Glu Gly Asp Tyr Lys Thr Ile Ala Lys
145                 150                 155                 160 
Glu Arg Lys Leu Leu Gln Asn Lys Arg Leu Asp Leu Asp Ala Ala Lys
                165                 170                 175     
Thr Arg Leu Lys Lys Ala Lys Ala Ala Glu Thr Arg Asn Ser Gln Leu
            180                 185                 190         
Asn Ser Ala Arg Leu Glu Gly Asp Asn Ile Met Ile Trp Ala Glu Glu
        195                 200                 205             
Val Thr Lys Ser Glu Gln Glu Leu Arg Ile Thr Gln Ser Glu Phe Asp
    210                 215                 220                 
Arg Gln Ala Glu Ile Thr Arg Leu Leu Leu Glu Gly Ile Ser Ser Thr
225                 230                 235                 240 
His Ala His His Leu Arg Cys Leu Asn Asp Phe Val Glu Ala Gln Met
                245                 250                 255     
Thr Tyr Tyr Ala Gln Cys Tyr Gln Tyr Met Leu Asp Leu Gln Lys Gln
            260                 265                 270         
Leu Gly Ser Phe Pro Ser Asn Tyr Leu Ser Asn Asn Asn Gln Thr Ser
        275                 280                 285             
Val Thr Pro Val Pro Ser Val Leu Pro Asn Ala Ile Gly Ser Ser Ala
    290                 295                 300                 
Met Ala Ser Thr Ser Gly Leu Val Ile Thr Ser Pro Ser Asn Leu Ser
305                 310                 315                 320 
Asp Leu Lys Glu Cys Ser Gly Ser Arg Lys Ala Arg Val Leu Tyr Asp
                325                 330                 335     
Tyr Asp Ala Ala Asn Ser Thr Glu Leu Ser Leu Leu Ala Asp Glu Val
            340                 345                 350         
Ile Thr Val Phe Ser Val Val Gly Met Asp Ser Asp Trp Leu Met Gly
        355                 360                 365             
Glu Arg Gly Asn Gln Lys Gly Lys Val Pro Ile Thr Tyr Leu Glu Leu
    370                 375                 380                 
Leu Asn
385     


<210> 8083
<211> 365
<212> PRT
<213> Homo sapiens

<400> 8083
Met Asn Ile Met Asp Phe Asn Val Lys Lys Leu Ala Ala Asp Ala Gly
 1               5                  10                  15      
Thr Phe Leu Ser Arg Ala Val Gln Phe Thr Glu Glu Lys Leu Gly Gln
            20                  25                  30          
Ala Glu Lys Thr Glu Leu Asp Ala His Leu Glu Asn Leu Leu Ser Lys
        35                  40                  45              
Ala Glu Cys Thr Lys Ile Trp Thr Glu Lys Ile Met Lys Gln Thr Glu
    50                  55                  60                  
Val Leu Leu Gln Pro Asn Pro Asn Ala Arg Ile Glu Glu Phe Val Tyr
65                  70                  75                  80  
Glu Lys Leu Asp Arg Lys Ala Pro Ser Arg Ile Asn Asn Pro Glu Leu
                85                  90                  95      
Leu Gly Gln Tyr Met Ile Asp Ala Gly Thr Glu Phe Gly Pro Gly Thr
            100                 105                 110         
Ala Tyr Gly Asn Ala Leu Ile Lys Cys Gly Glu Thr Gln Lys Arg Ile
        115                 120                 125             
Gly Thr Ala Asp Arg Glu Leu Ile Gln Thr Ser Ala Leu Asn Phe Leu
    130                 135                 140                 
Thr Pro Leu Arg Asn Phe Ile Glu Gly Asp Tyr Lys Thr Ile Ala Lys
145                 150                 155                 160 
Glu Arg Lys Leu Leu Gln Asn Lys Arg Leu Asp Leu Asp Ala Ala Lys
                165                 170                 175     
Thr Arg Leu Lys Lys Ala Lys Ala Ala Glu Thr Arg Asn Ser Ser Glu
            180                 185                 190         
Gln Glu Leu Arg Ile Thr Gln Ser Glu Phe Asp Arg Gln Ala Glu Ile
        195                 200                 205             
Thr Arg Leu Leu Leu Glu Gly Ile Ser Ser Thr His Ala His His Leu
    210                 215                 220                 
Arg Cys Leu Asn Asp Phe Val Glu Ala Gln Met Thr Tyr Tyr Ala Gln
225                 230                 235                 240 
Cys Tyr Gln Tyr Met Leu Asp Leu Gln Lys Gln Leu Gly Ser Phe Pro
                245                 250                 255     
Ser Asn Tyr Leu Ser Asn Asn Asn Gln Thr Ser Val Thr Pro Val Pro
            260                 265                 270         
Ser Val Leu Pro Asn Ala Ile Gly Ser Ser Ala Met Ala Ser Thr Ser
        275                 280                 285             
Gly Leu Val Ile Thr Ser Pro Ser Asn Leu Ser Asp Leu Lys Glu Cys
    290                 295                 300                 
Ser Gly Ser Arg Lys Ala Arg Val Leu Tyr Asp Tyr Asp Ala Ala Asn
305                 310                 315                 320 
Ser Thr Glu Leu Ser Leu Leu Ala Asp Glu Val Ile Thr Val Phe Ser
                325                 330                 335     
Val Val Gly Met Asp Ser Asp Trp Leu Met Gly Glu Arg Gly Asn Gln
            340                 345                 350         
Lys Gly Lys Val Pro Ile Thr Tyr Leu Glu Leu Leu Asn
        355                 360                 365 


<210> 8084
<211> 3114
<212> PRT
<213> Homo sapiens

<400> 8084
Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr
 1               5                  10                  15      
Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly
            20                  25                  30          
Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys
        35                  40                  45              
Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile
    50                  55                  60                  
Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp
65                  70                  75                  80  
Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile
                85                  90                  95      
Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile
            100                 105                 110         
Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser
        115                 120                 125             
Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro
    130                 135                 140                 
Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro
145                 150                 155                 160 
Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe
                165                 170                 175     
Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile
            180                 185                 190         
Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro
        195                 200                 205             
Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His
    210                 215                 220                 
Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln
225                 230                 235                 240 
Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys
                245                 250                 255     
Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys
            260                 265                 270         
Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser
        275                 280                 285             
Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro
    290                 295                 300                 
Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly
305                 310                 315                 320 
Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met
                325                 330                 335     
Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile
            340                 345                 350         
Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala
        355                 360                 365             
Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu
    370                 375                 380                 
Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val
385                 390                 395                 400 
Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn
                405                 410                 415     
Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys
            420                 425                 430         
Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser
        435                 440                 445             
Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly
    450                 455                 460                 
Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr
465                 470                 475                 480 
Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys
                485                 490                 495     
Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile
            500                 505                 510         
Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn
        515                 520                 525             
Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro
    530                 535                 540                 
Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile
545                 550                 555                 560 
Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser
                565                 570                 575     
Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys
            580                 585                 590         
Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro
        595                 600                 605             
Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys
    610                 615                 620                 
Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys
625                 630                 635                 640 
Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp
                645                 650                 655     
Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu
            660                 665                 670         
Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser
        675                 680                 685             
Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser
    690                 695                 700                 
Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys
705                 710                 715                 720 
Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser
                725                 730                 735     
Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu
            740                 745                 750         
Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr
        755                 760                 765             
Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly
    770                 775                 780                 
Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His
785                 790                 795                 800 
Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu
                805                 810                 815     
Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu
            820                 825                 830         
Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala
        835                 840                 845             
Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr
    850                 855                 860                 
Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro
865                 870                 875                 880 
Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg
                885                 890                 895     
Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys
            900                 905                 910         
Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys
        915                 920                 925             
Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly
    930                 935                 940                 
Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp
945                 950                 955                 960 
Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln
                965                 970                 975     
Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln
            980                 985                 990         
Val Lys Leu Met Asp Leu Glu Asp Cys Ala Leu Trp Glu Gly Lys Pro
        995                 1000                1005            
Arg Thr Tyr Ile Thr Glu Glu Arg Ala Asp Val Ser Leu Thr Thr Leu
    1010                1015                1020                
Leu Thr Ala Gln Ala Ser Leu Lys Thr Lys Pro Ile His Thr Ile Ile
1025                1030                1035                1040
Arg Lys Arg Ala Pro Pro Cys Asn Asn Asp Phe Cys Arg Leu Gly Cys
                1045                1050                1055    
Val Cys Ser Ser Leu Ala Leu Glu Lys Arg Gln Pro Ala His Cys Arg
            1060                1065                1070        
Arg Pro Asp Cys Met Phe Gly Cys Thr Cys Leu Lys Arg Lys Val Val
        1075                1080                1085            
Leu Val Lys Gly Gly Ser Lys Thr Lys His Phe Gln Arg Lys Ala Ala
    1090                1095                1100                
His Arg Asp Pro Val Phe Tyr Asp Thr Leu Gly Glu Glu Ala Arg Glu
1105                1110                1115                1120
Glu Glu Glu Gly Ile Arg Glu Glu Glu Glu Gln Leu Lys Glu Lys Lys
                1125                1130                1135    
Lys Arg Lys Lys Leu Glu Tyr Thr Ile Cys Glu Thr Glu Pro Glu Gln
            1140                1145                1150        
Pro Val Arg His Tyr Pro Leu Trp Val Lys Val Glu Gly Glu Val Asp
        1155                1160                1165            
Pro Glu Pro Val Tyr Ile Pro Thr Pro Ser Val Ile Glu Pro Met Lys
    1170                1175                1180                
Pro Leu Leu Leu Pro Gln Pro Glu Val Leu Ser Pro Thr Val Lys Gly
1185                1190                1195                1200
Lys Leu Leu Thr Gly Ile Lys Ser Pro Arg Ser Tyr Thr Pro Lys Pro
                1205                1210                1215    
Asn Pro Val Ile Arg Glu Glu Asp Lys Asp Pro Val Tyr Leu Tyr Phe
            1220                1225                1230        
Glu Ser Met Met Thr Cys Ala Arg Val Arg Val Tyr Glu Arg Lys Lys
        1235                1240                1245            
Glu Asp Gln Arg Gln Pro Ser Ser Ser Ser Ser Pro Ser Pro Ser Phe
    1250                1255                1260                
Gln Gln Gln Thr Ser Cys His Ser Ser Pro Glu Asn His Asn Asn Ala
1265                1270                1275                1280
Lys Glu Pro Asp Ser Glu Gln Gln Pro Leu Lys Gln Leu Thr Cys Asp
                1285                1290                1295    
Leu Glu Asp Asp Ser Asp Lys Leu Gln Glu Lys Ser Trp Lys Ser Ser
            1300                1305                1310        
Cys Asn Glu Gly Glu Ser Ser Ser Thr Ser Tyr Met His Gln Arg Ser
        1315                1320                1325            
Pro Gly Gly Pro Thr Lys Leu Ile Glu Ile Ile Ser Asp Cys Asn Trp
    1330                1335                1340                
Glu Glu Asp Arg Asn Lys Ile Leu Ser Ile Leu Ser Gln His Ile Asn
1345                1350                1355                1360
Ser Asn Met Pro Gln Ser Leu Lys Val Gly Ser Phe Ile Ile Glu Leu
                1365                1370                1375    
Ala Ser Gln Arg Lys Ser Arg Gly Glu Lys Asn Pro Pro Val Tyr Ser
            1380                1385                1390        
Ser Arg Val Lys Ile Ser Met Pro Ser Cys Gln Asp Gln Asp Asp Met
        1395                1400                1405            
Ala Glu Lys Ser Gly Ser Glu Thr Pro Asp Gly Pro Leu Ser Pro Gly
    1410                1415                1420                
Lys Met Glu Asp Ile Ser Pro Val Gln Thr Asp Ala Leu Asp Ser Val
1425                1430                1435                1440
Arg Glu Arg Leu His Gly Gly Lys Gly Leu Pro Phe Tyr Ala Gly Leu
                1445                1450                1455    
Ser Pro Ala Gly Lys Leu Val Ala Tyr Lys Arg Lys Pro Ser Ser Ser
            1460                1465                1470        
Thr Ser Gly Leu Ile Gln Val Asn Gly Lys Ser Tyr Pro Gln Ala Lys
        1475                1480                1485            
Leu Leu Leu Gly Gln Met Gly Ala Leu His Pro Ala Asn Arg Leu Ala
    1490                1495                1500                
Ala Tyr Ile Thr Gly Arg Leu Arg Pro Ser Val Leu Asp Leu Ser Thr
1505                1510                1515                1520
Leu Ser Thr Val Ile Ser Lys Val Ala Ser Asn Ala Lys Val Ala Ala
                1525                1530                1535    
Ser Arg Lys Pro Arg Thr Leu Leu Pro Ser Thr Ser Asn Ser Lys Met
            1540                1545                1550        
Ala Ser Ser Ser Gly Thr Ala Thr Asn Arg Pro Gly Lys Asn Leu Lys
        1555                1560                1565            
Ala Phe Val Pro Ala Lys Arg Pro Ile Ala Ala Arg Pro Ser Pro Gly
    1570                1575                1580                
Gly Val Phe Thr Gln Phe Val Met Ser Lys Val Gly Ala Leu Gln Gln
1585                1590                1595                1600
Lys Ile Pro Gly Val Ser Thr Pro Gln Thr Leu Ala Gly Thr Gln Lys
                1605                1610                1615    
Phe Ser Ile Arg Pro Ser Pro Val Met Val Val Thr Pro Val Val Ser
            1620                1625                1630        
Ser Glu Pro Val Gln Val Cys Ser Pro Val Thr Ala Ala Val Thr Thr
        1635                1640                1645            
Thr Thr Pro Gln Val Phe Leu Glu Asn Thr Thr Ala Val Thr Pro Met
    1650                1655                1660                
Thr Ala Ile Ser Asp Val Glu Thr Lys Glu Thr Thr Tyr Ser Ser Gly
1665                1670                1675                1680
Ala Thr Thr Thr Gly Val Val Glu Val Ser Glu Thr Asn Thr Ser Thr
                1685                1690                1695    
Ser Val Thr Ser Thr Gln Ser Thr Ala Thr Val Asn Leu Thr Lys Thr
            1700                1705                1710        
Thr Gly Ile Thr Thr Pro Val Ala Ser Val Ala Phe Pro Lys Ser Leu
        1715                1720                1725            
Val Ala Ser Pro Ser Thr Ile Thr Leu Pro Val Ala Ser Thr Ala Ser
    1730                1735                1740                
Thr Ser Leu Val Val Val Thr Ala Ala Ala Ser Ser Ser Met Val Thr
1745                1750                1755                1760
Thr Pro Thr Ser Ser Leu Gly Ser Val Pro Ile Ile Leu Ser Gly Ile
                1765                1770                1775    
Asn Gly Ser Pro Pro Val Ser Gln Arg Pro Glu Asn Ala Ala Gln Ile
            1780                1785                1790        
Pro Val Ala Thr Pro Gln Val Ser Pro Asn Thr Val Lys Arg Ala Gly
        1795                1800                1805            
Pro Arg Leu Leu Leu Ile Pro Val Gln Gln Gly Ser Pro Thr Leu Arg
    1810                1815                1820                
Pro Val Ser Asn Thr Gln Leu Gln Gly His Arg Met Val Leu Gln Pro
1825                1830                1835                1840
Val Arg Ser Pro Ser Gly Met Asn Leu Phe Arg His Pro Asn Gly Gln
                1845                1850                1855    
Ile Val Gln Leu Leu Pro Leu His Gln Leu Arg Gly Ser Asn Thr Gln
            1860                1865                1870        
Pro Asn Leu Gln Pro Val Met Phe Arg Asn Pro Gly Ser Val Met Gly
        1875                1880                1885            
Ile Arg Leu Pro Ala Pro Ser Lys Pro Ser Glu Thr Pro Pro Ser Ser
    1890                1895                1900                
Thr Ser Ser Ser Ala Phe Ser Val Met Asn Pro Val Ile Gln Ala Val
1905                1910                1915                1920
Gly Ser Ser Ser Ala Val Asn Val Ile Thr Gln Ala Pro Ser Leu Leu
                1925                1930                1935    
Ser Ser Gly Ala Ser Phe Val Ser Gln Ala Gly Thr Leu Thr Leu Arg
            1940                1945                1950        
Ile Ser Pro Pro Glu Pro Gln Ser Phe Ala Ser Lys Thr Gly Ser Glu
        1955                1960                1965            
Thr Lys Ile Thr Tyr Ser Ser Gly Gly Gln Pro Val Gly Thr Ala Ser
    1970                1975                1980                
Leu Ile Pro Leu Gln Ser Gly Ser Phe Ala Leu Leu Gln Leu Pro Gly
1985                1990                1995                2000
Gln Lys Pro Val Pro Ser Ser Ile Leu Gln His Val Ala Ser Leu Gln
                2005                2010                2015    
Met Lys Arg Glu Ser Gln Asn Pro Asp Gln Lys Asp Glu Thr Asn Ser
            2020                2025                2030        
Ile Lys Arg Glu Gln Glu Thr Lys Lys Val Leu Gln Ser Glu Gly Glu
        2035                2040                2045            
Ala Val Asp Pro Glu Ala Asn Val Ile Lys Gln Asn Ser Gly Ala Ala
    2050                2055                2060                
Thr Ser Glu Glu Thr Leu Asn Asp Ser Leu Glu Asp Arg Gly Asp His
2065                2070                2075                2080
Leu Asp Glu Glu Cys Leu Pro Glu Glu Gly Cys Ala Thr Val Lys Pro
                2085                2090                2095    
Ser Glu His Ser Cys Ile Thr Gly Ser His Thr Asp Gln Asp Tyr Lys
            2100                2105                2110        
Asp Val Asn Glu Glu Tyr Gly Ala Arg Asn Arg Lys Ser Ser Lys Glu
        2115                2120                2125            
Lys Val Ala Val Leu Glu Val Arg Thr Ile Ser Glu Lys Ala Ser Asn
    2130                2135                2140                
Lys Thr Val Gln Asn Leu Ser Lys Val Gln His Gln Lys Leu Gly Asp
2145                2150                2155                2160
Val Lys Val Glu Gln Gln Lys Gly Phe Asp Asn Pro Glu Glu Asn Ser
                2165                2170                2175    
Ser Glu Phe Pro Val Thr Phe Lys Glu Glu Ser Lys Phe Glu Leu Ser
            2180                2185                2190        
Gly Ser Lys Val Met Glu Gln Gln Ser Asn Leu Gln Pro Glu Ala Lys
        2195                2200                2205            
Glu Lys Glu Cys Gly Asp Ser Leu Glu Lys Asp Arg Glu Arg Trp Arg
    2210                2215                2220                
Lys His Leu Lys Gly Pro Leu Thr Arg Lys Cys Val Gly Ala Ser Gln
2225                2230                2235                2240
Glu Cys Lys Lys Glu Ala Asp Glu Gln Leu Ile Lys Glu Thr Lys Thr
                2245                2250                2255    
Cys Gln Glu Asn Ser Asp Val Phe Gln Gln Glu Gln Gly Ile Ser Asp
            2260                2265                2270        
Leu Leu Gly Lys Ser Gly Ile Thr Glu Asp Ala Arg Val Leu Lys Thr
        2275                2280                2285            
Glu Cys Asp Ser Trp Ser Arg Ile Ser Asn Pro Ser Ala Phe Ser Ile
    2290                2295                2300                
Val Pro Arg Arg Ala Ala Lys Ser Ser Arg Gly Asn Gly His Phe Gln
2305                2310                2315                2320
Gly His Leu Leu Leu Pro Gly Glu Gln Ile Gln Pro Lys Gln Glu Lys
                2325                2330                2335    
Lys Gly Gly Arg Ser Ser Ala Asp Phe Thr Val Leu Asp Leu Glu Glu
            2340                2345                2350        
Asp Asp Glu Asp Asp Asn Glu Lys Thr Asp Asp Ser Ile Asp Glu Ile
        2355                2360                2365            
Val Asp Val Val Ser Asp Tyr Gln Ser Glu Glu Val Asp Asp Val Glu
    2370                2375                2380                
Lys Asn Asn Cys Val Glu Tyr Ile Glu Asp Asp Glu Glu His Val Asp
2385                2390                2395                2400
Ile Glu Thr Val Glu Glu Leu Ser Glu Glu Ile Asn Val Ala His Leu
                2405                2410                2415    
Lys Thr Thr Ala Ala His Thr Gln Ser Phe Lys Gln Pro Ser Cys Thr
            2420                2425                2430        
His Ile Ser Ala Asp Glu Lys Ala Ala Glu Arg Ser Arg Lys Ala Pro
        2435                2440                2445            
Pro Ile Pro Leu Lys Leu Lys Pro Asp Tyr Trp Ser Asp Lys Leu Gln
    2450                2455                2460                
Lys Glu Ala Glu Ala Phe Ala Tyr Tyr Arg Arg Thr His Thr Ala Asn
2465                2470                2475                2480
Glu Arg Arg Arg Arg Gly Glu Met Arg Asp Leu Phe Glu Lys Leu Lys
                2485                2490                2495    
Ile Thr Leu Gly Leu Leu His Ser Ser Lys Val Ser Lys Ser Leu Ile
            2500                2505                2510        
Leu Thr Arg Ala Phe Ser Glu Ile Gln Gly Leu Thr Asp Gln Ala Asp
        2515                2520                2525            
Lys Leu Ile Gly Gln Lys Asn Leu Leu Thr Arg Lys Arg Asn Ile Leu
    2530                2535                2540                
Ile Arg Lys Val Ser Ser Leu Ser Gly Lys Thr Glu Glu Val Val Leu
2545                2550                2555                2560
Lys Lys Leu Glu Tyr Ile Tyr Ala Lys Gln Gln Ala Leu Glu Ala Gln
                2565                2570                2575    
Lys Arg Lys Lys Lys Met Gly Ser Asp Glu Phe Asp Ile Ser Pro Arg
            2580                2585                2590        
Ile Ser Lys Gln Gln Glu Gly Ser Ser Ala Ser Ser Val Asp Leu Gly
        2595                2600                2605            
Gln Met Phe Ile Asn Asn Arg Arg Gly Lys Pro Leu Ile Leu Ser Arg
    2610                2615                2620                
Lys Lys Asp Gln Ala Thr Glu Asn Thr Ser Pro Leu Asn Thr Pro His
2625                2630                2635                2640
Thr Ser Ala Asn Leu Val Met Thr Pro Gln Gly Gln Leu Leu Thr Leu
                2645                2650                2655    
Lys Gly Pro Leu Phe Ser Gly Pro Val Val Ala Val Ser Pro Asp Leu
            2660                2665                2670        
Leu Glu Ser Asp Leu Lys Pro Gln Val Ala Gly Ser Ala Val Ala Leu
        2675                2680                2685            
Pro Glu Asn Asp Asp Leu Phe Met Met Pro Arg Ile Val Asn Val Thr
    2690                2695                2700                
Ser Leu Ala Thr Glu Gly Gly Leu Val Asp Met Gly Gly Ser Lys Tyr
2705                2710                2715                2720
Pro His Glu Val Pro Asp Ser Lys Pro Ser Asp His Leu Lys Asp Thr
                2725                2730                2735    
Val Arg Asn Glu Asp Asn Ser Leu Glu Asp Lys Gly Arg Ile Ser Ser
            2740                2745                2750        
Arg Gly Asn Arg Asp Gly Arg Val Thr Leu Gly Pro Thr Gln Val Phe
        2755                2760                2765            
Leu Ala Asn Lys Asp Ser Gly Tyr Pro Gln Ile Val Asp Val Ser Asn
    2770                2775                2780                
Met Gln Lys Ala Gln Glu Phe Leu Pro Lys Lys Ile Ser Gly Asp Met
2785                2790                2795                2800
Arg Gly Ile Gln Tyr Lys Trp Lys Glu Ser Glu Ser Arg Gly Glu Arg
                2805                2810                2815    
Val Lys Ser Lys Asp Ser Ser Phe His Lys Leu Lys Met Lys Asp Leu
            2820                2825                2830        
Lys Asp Ser Ser Ile Glu Met Glu Leu Arg Lys Val Thr Ser Ala Ile
        2835                2840                2845            
Glu Glu Ala Ala Leu Asp Ser Ser Glu Leu Leu Thr Asn Met Glu Asp
    2850                2855                2860                
Glu Asp Asp Thr Asp Glu Thr Leu Thr Ser Leu Leu Asn Glu Ile Ala
2865                2870                2875                2880
Phe Leu Asn Gln Gln Leu Asn Asp Asp Ser Val Gly Leu Ala Glu Leu
                2885                2890                2895    
Pro Ser Ser Met Asp Thr Glu Phe Pro Gly Asp Ala Arg Arg Ala Phe
            2900                2905                2910        
Ile Ser Lys Val Pro Pro Gly Ser Arg Ala Thr Phe Gln Val Glu His
        2915                2920                2925            
Leu Gly Thr Gly Leu Lys Glu Leu Pro Asp Val Gln Gly Glu Ser Asp
    2930                2935                2940                
Ser Ile Ser Pro Leu Leu Leu His Leu Glu Asp Asp Asp Phe Ser Glu
2945                2950                2955                2960
Asn Glu Lys Gln Leu Ala Glu Pro Ala Ser Glu Pro Asp Val Leu Lys
                2965                2970                2975    
Ile Val Ile Asp Ser Glu Ile Lys Asp Ser Leu Leu Ser Asn Lys Lys
            2980                2985                2990        
Ala Ile Asp Gly Gly Lys Asn Thr Ser Gly Leu Pro Ala Glu Pro Glu
        2995                3000                3005            
Ser Val Ser Ser Pro Pro Thr Leu His Met Lys Thr Gly Leu Glu Asn
    3010                3015                3020                
Ser Asn Ser Thr Asp Thr Leu Trp Arg Pro Met Pro Lys Leu Ala Pro
3025                3030                3035                3040
Leu Gly Leu Lys Val Ala Asn Pro Ser Ser Asp Ala Asp Gly Gln Ser
                3045                3050                3055    
Leu Lys Val Met Pro Cys Leu Ala Pro Ile Ala Ala Lys Val Gly Ser
            3060                3065                3070        
Val Gly His Lys Met Asn Leu Thr Gly Asn Asp Gln Glu Gly Arg Glu
        3075                3080                3085            
Ser Lys Val Met Pro Thr Leu Ala Pro Val Val Ala Lys Leu Gly Asn
    3090                3095                3100                
Ser Gly Ala Ser Pro Ser Ser Ala Gly Lys
3105                3110                


<210> 8085
<211> 192
<212> PRT
<213> Homo sapiens

<400> 8085
Met Ser Lys Arg Asn Gln Val Ser Tyr Val Arg Pro Ala Glu Pro Ala
 1               5                  10                  15      
Phe Leu Ala Arg Phe Lys Glu Arg Val Gly Tyr Arg Glu Gly Pro Thr
            20                  25                  30          
Val Glu Thr Lys Ala Leu Cys Leu Ser Arg Arg His Leu Pro Ser Gly
        35                  40                  45              
Asn Gln Gln Lys Asn Ile Gly Thr Thr Val Gln Tyr Met Leu Pro Met
    50                  55                  60                  
Ser Tyr Ala Gln Cys Lys Lys Gln Glu Lys Arg Ile Gln Pro Gln Pro
65                  70                  75                  80  
Pro Asp Glu Asp Gly Asp His Ser Asp Lys Glu Asp Glu Gln Pro Gln
                85                  90                  95      
Val Val Val Leu Lys Lys Gly Asp Leu Ser Val Glu Glu Val Met Lys
            100                 105                 110         
Ile Lys Ala Glu Ile Lys Ala Ala Lys Ala Asp Glu Glu Pro Thr Pro
        115                 120                 125             
Ala Asp Gly Arg Ile Ile Tyr Arg Lys Pro Val Lys His Pro Ser Asp
    130                 135                 140                 
Glu Lys Tyr Ser Gly Leu Thr Ala Ser Ser Lys Lys Lys Lys Pro Asn
145                 150                 155                 160 
Glu Asp Glu Val Asn Gln Asp Ser Val Lys Lys Asn Ser Gln Lys Gln
                165                 170                 175     
Ile Lys Asn Ser Ser Leu Leu Ser Phe Asp Asn Glu Asp Glu Asn Glu
            180                 185                 190         


<210> 8086
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8086
Met Ser Lys Arg Asn Gln Val Ser Tyr Val Arg Pro Ala Glu Pro Ala
 1               5                  10                  15      
Phe Leu Ala Arg Phe Lys Glu Arg Val Gly Tyr Arg Glu Gly Pro Thr
            20                  25                  30          
Val Glu Thr Lys Arg Ile Gln Pro Gln Pro Pro Asp Glu Asp Gly Asp
        35                  40                  45              
His Ser Asp Lys Glu Asp Glu Gln Pro Gln Val Val Val Leu Lys Lys
    50                  55                  60                  
Gly Asp Leu Ser Val Glu Glu Val Met Lys Ile Lys Ala Glu Ile Lys
65                  70                  75                  80  
Ala Ala Lys Ala Asp Glu Glu Pro Thr Pro Ala Asp Gly Arg Ile Ile
                85                  90                  95      
Tyr Arg Lys Pro Val Lys His Pro Ser Asp Glu Lys Tyr Ser Gly Leu
            100                 105                 110         
Thr Ala Ser Ser Lys Lys Lys Lys Pro Asn Glu Asp Glu Val Asn Gln
        115                 120                 125             
Asp Ser Val Lys Lys Asn Ser Gln Lys Gln Ile Lys Asn Ser Ser Leu
    130                 135                 140                 
Leu Ser Phe Asp Asn Glu Asp Glu Asn Glu
145                 150                 


<210> 8087
<211> 398
<212> PRT
<213> Homo sapiens

<400> 8087
Gln His Ser Ser Ser Leu Gly Gly Leu Ser His Ser Glu Glu Ile Pro
 1               5                  10                  15      
Asn Thr Thr Thr Thr Gln His Ser Ser Thr Leu Ser Thr Gln Gln Asn
            20                  25                  30          
Thr Leu Ser Ser Ser Thr Ser Ser Gly Arg Thr Ser Thr Ser Thr Leu
        35                  40                  45              
Leu His Thr Ser Val Glu Ser Glu Ala Asn Leu His Ser Ser Ser Ser
    50                  55                  60                  
Thr Phe Ser Thr Thr Ser Ser Thr Val Ser Ala Pro Pro Pro Val Val
65                  70                  75                  80  
Ser Val Ser Ser Ser Leu Asn Ser Gly Ser Ser Leu Gly Leu Ser Leu
                85                  90                  95      
Gly Ser Asn Ser Thr Val Thr Ala Ser Thr Arg Ser Ser Val Ala Thr
            100                 105                 110         
Thr Ser Gly Lys Ala Pro Pro Asn Leu Pro Pro Gly Val Pro Pro Leu
        115                 120                 125             
Leu Pro Asn Pro Tyr Ile Met Ala Pro Gly Leu Leu His Ala Tyr Pro
    130                 135                 140                 
Pro Gln Val Tyr Gly Tyr Asp Asp Leu Gln Met Leu Gln Thr Arg Phe
145                 150                 155                 160 
Pro Leu Asp Tyr Tyr Ser Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu
                165                 170                 175     
Thr Gly Arg Asp Gly Ser Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu
            180                 185                 190         
Thr Lys Phe Gly Arg Gly Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr
        195                 200                 205             
Leu Ala Gln Pro Gln Gln Asn Gln Thr Gln Thr His His Thr Thr Gln
    210                 215                 220                 
Gln Thr Phe Leu Asn Pro Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser
225                 230                 235                 240 
Leu Pro Tyr Tyr Thr Gly Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr
                245                 250                 255     
Gly Pro Ala Val Phe Pro Val Ala Pro Thr Ser Ser Lys Gln His Gly
            260                 265                 270         
Val Asn Val Ser Val Asn Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser
        275                 280                 285             
Gly Tyr Gly Ser His Gly Tyr Asn Thr Gly Val Ser Val Thr Ser Ser
    290                 295                 300                 
Asn Thr Gly Val Pro Asp Ile Ser Gly Ser Val Tyr Ser Lys Thr Gln
305                 310                 315                 320 
Gln Ser Phe Glu Lys Gln Gly Phe His Ser Gly Thr Pro Ala Ala Ser
                325                 330                 335     
Phe Asn Leu Pro Ser Ala Leu Gly Ser Gly Gly Pro Ile Asn Pro Ala
            340                 345                 350         
Thr Ala Ala Ala Tyr Pro Pro Ala Pro Phe Met His Ile Leu Thr Pro
        355                 360                 365             
His Gln Gln Pro His Ser Gln Ile Leu His His His Leu Gln Gln Asp
    370                 375                 380                 
Gly Gln Asp Ile Leu Asn Phe Val Asp Asp Gln Leu Gly Glu
385                 390                 395             


<210> 8088
<211> 408
<212> PRT
<213> Homo sapiens

<400> 8088
Ser Ser Leu Gly Leu Ser Leu Gly Ser Asn Ser Thr Val Thr Ala Ser
 1               5                  10                  15      
Thr Arg Ser Ser Val Ala Thr Thr Ser Gly Lys Ala Pro Pro Asn Leu
            20                  25                  30          
Pro Pro Gly Val Pro Pro Leu Leu Pro Asn Pro Tyr Ile Met Ala Pro
        35                  40                  45              
Gly Leu Leu His Ala Tyr Pro Pro Gln Val Tyr Gly Tyr Asp Asp Leu
    50                  55                  60                  
Gln Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser Ile Pro Phe
65                  70                  75                  80  
Pro Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser Leu Ala Ser
                85                  90                  95      
Asn Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly Asp Ala Ser
            100                 105                 110         
Ser Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln Asn Gln Thr
        115                 120                 125             
Gln Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro Ala Leu Pro
    130                 135                 140                 
Pro Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly Val Pro Gly
145                 150                 155                 160 
Leu Pro Ser Thr Phe Gln Tyr Gly Pro Ala Val Phe Pro Val Ala Pro
                165                 170                 175     
Thr Ser Ser Lys Gln His Gly Val Asn Val Ser Val Asn Ala Ser Ala
            180                 185                 190         
Thr Pro Phe Gln Gln Pro Ser Gly Tyr Gly Ser His Gly Tyr Asn Thr
        195                 200                 205             
Gly Val Ser Val Thr Ser Ser Asn Thr Gly Val Pro Asp Ile Ser Gly
    210                 215                 220                 
Ser Val Tyr Ser Lys Thr Gln Gln Ser Phe Glu Lys Gln Gly Phe His
225                 230                 235                 240 
Ser Gly Thr Pro Ala Ala Ser Phe Asn Leu Pro Ser Ala Leu Gly Ser
                245                 250                 255     
Gly Gly Pro Ile Asn Pro Ala Thr Ala Ala Ala Tyr Pro Pro Ala Pro
            260                 265                 270         
Phe Met His Ile Leu Thr Pro His Gln Gln Pro His Ser Gln Ile Leu
        275                 280                 285             
His His His Leu Gln Gln Asp Gly Gln Leu Pro Tyr Leu Gln Met Ile
    290                 295                 300                 
Leu Cys Cys Gln Arg Gln Gln Glu Glu Gln Thr Gly Ser Gly Gln Arg
305                 310                 315                 320 
Ser Gln Thr Ser Ser Ile Pro Gln Lys Pro Gln Thr Asn Lys Ser Ala
                325                 330                 335     
Tyr Asn Ser Tyr Ser Trp Gly Pro Thr Glu Ala Leu Thr Leu Phe Ser
            340                 345                 350         
Arg Ser His Leu Leu Arg Gly Leu Leu Ser Leu Glu Thr Met Glu Thr
        355                 360                 365             
Ala Ser Lys Arg Lys Glu Cys Gly Gly Phe Pro Leu Pro Pro Thr Pro
    370                 375                 380                 
Ser Gly Pro Pro His Ala Ser Ala Ser Cys Leu Ser His Ser Tyr Thr
385                 390                 395                 400 
Ile Pro Thr Leu Leu Tyr Val Leu
                405             


<210> 8089
<211> 889
<212> PRT
<213> Homo sapiens

<400> 8089
Met Glu Glu Gly Ala Pro Arg Gln Pro Gly Pro Ser Gln Trp Pro Pro
 1               5                  10                  15      
Glu Asp Glu Lys Glu Val Ile Arg Arg Ala Ile Gln Lys Glu Leu Lys
            20                  25                  30          
Ile Lys Glu Gly Val Glu Asn Leu Arg Arg Val Ala Thr Asp Arg Arg
        35                  40                  45              
His Leu Gly His Val Gln Gln Leu Leu Arg Ser Ser Asn Arg Arg Leu
    50                  55                  60                  
Glu Gln Leu His Gly Glu Leu Arg Glu Leu His Ala Arg Ile Leu Leu
65                  70                  75                  80  
Pro Gly Pro Gly Pro Gly Pro Ala Glu Pro Val Ala Ser Gly Pro Arg
                85                  90                  95      
Pro Trp Ala Glu Gln Leu Arg Ala Arg His Leu Glu Ala Leu Arg Arg
            100                 105                 110         
Gln Leu His Val Glu Leu Lys Val Lys Gln Gly Ala Glu Asn Met Thr
        115                 120                 125             
His Thr Cys Ala Ser Gly Thr Pro Lys Glu Arg Lys Leu Leu Ala Ala
    130                 135                 140                 
Ala Gln Gln Met Leu Arg Asp Ser Gln Leu Lys Val Ala Leu Leu Arg
145                 150                 155                 160 
Met Lys Ile Ser Ser Leu Glu Ala Ser Gly Ser Pro Glu Pro Gly Pro
                165                 170                 175     
Glu Leu Leu Ala Glu Glu Leu Gln His Arg Leu His Val Glu Ala Ala
            180                 185                 190         
Val Ala Glu Gly Ala Lys Asn Val Val Lys Leu Leu Ser Ser Arg Arg
        195                 200                 205             
Thr Gln Asp Arg Lys Ala Leu Ala Glu Ala Gln Ala Gln Leu Gln Glu
    210                 215                 220                 
Ser Ser Gln Lys Leu Asp Leu Leu Arg Leu Ala Leu Glu Gln Leu Leu
225                 230                 235                 240 
Glu Gln Leu Pro Pro Ala His Pro Leu Arg Ser Arg Val Thr Arg Glu
                245                 250                 255     
Leu Arg Ala Ala Val Pro Gly Tyr Pro Gln Pro Ser Gly Thr Pro Val
            260                 265                 270         
Lys Pro Thr Ala Leu Thr Gly Thr Leu Gln Val Arg Leu Leu Gly Cys
        275                 280                 285             
Glu Gln Leu Leu Thr Ala Val Pro Gly Arg Ser Pro Ala Ala Ala Leu
    290                 295                 300                 
Ala Ser Ser Pro Ser Glu Gly Trp Leu Arg Thr Lys Ala Lys His Gln
305                 310                 315                 320 
Arg Gly Arg Gly Glu Leu Ala Ser Glu Val Leu Ala Val Leu Lys Val
                325                 330                 335     
Asp Asn Arg Val Val Gly Gln Thr Gly Trp Gly Gln Val Ala Glu Gln
            340                 345                 350         
Ser Trp Asp Gln Thr Phe Val Ile Pro Leu Glu Arg Ala Arg Glu Leu
        355                 360                 365             
Glu Ile Gly Val His Trp Arg Asp Trp Arg Gln Leu Cys Gly Val Ala
    370                 375                 380                 
Phe Leu Arg Leu Glu Asp Phe Leu Asp Asn Ala Cys His Gln Leu Ser
385                 390                 395                 400 
Leu Ser Leu Val Pro Gln Gly Leu Leu Phe Ala Gln Val Thr Phe Cys
                405                 410                 415     
Asp Pro Val Ile Glu Arg Arg Pro Arg Leu Gln Arg Gln Glu Arg Ile
            420                 425                 430         
Phe Ser Lys Arg Arg Gly Gln Asp Phe Leu Arg Arg Ser Gln Met Asn
        435                 440                 445             
Leu Gly Met Ala Ala Trp Gly Arg Leu Val Met Asn Leu Leu Pro Pro
    450                 455                 460                 
Cys Ser Ser Pro Ser Thr Ile Ser Pro Pro Lys Gly Cys Pro Arg Thr
465                 470                 475                 480 
Pro Thr Thr Leu Arg Glu Ala Ser Asp Pro Ala Thr Pro Ser Asn Phe
                485                 490                 495     
Leu Pro Lys Lys Thr Pro Leu Gly Glu Glu Met Thr Pro Pro Pro Lys
            500                 505                 510         
Pro Pro Arg Leu Tyr Leu Pro Gln Glu Pro Thr Ser Glu Glu Thr Pro
        515                 520                 525             
Arg Thr Lys Arg Pro His Met Glu Pro Arg Thr Arg Arg Gly Pro Ser
    530                 535                 540                 
Pro Pro Ala Ser Pro Thr Arg Lys Pro Pro Arg Leu Gln Asp Phe Arg
545                 550                 555                 560 
Cys Leu Ala Val Leu Gly Arg Gly His Phe Gly Lys Val Leu Leu Val
                565                 570                 575     
Gln Phe Lys Gly Thr Gly Lys Tyr Tyr Ala Ile Lys Ala Leu Lys Lys
            580                 585                 590         
Gln Glu Val Leu Ser Arg Asp Glu Ile Glu Ser Leu Tyr Cys Glu Lys
        595                 600                 605             
Arg Ile Leu Glu Ala Val Gly Cys Thr Gly His Pro Phe Leu Leu Ser
    610                 615                 620                 
Leu Leu Val Cys Phe Gln Thr Ser Ser His Ala Arg Phe Val Thr Glu
625                 630                 635                 640 
Phe Val Pro Gly Gly Asp Leu Met Met Gln Ile His Glu Asp Val Phe
                645                 650                 655     
Pro Glu Pro Gln Ala Arg Phe Tyr Val Ala Cys Val Val Leu Gly Leu
            660                 665                 670         
Gln Phe Leu His Glu Lys Lys Ile Ile Tyr Arg Asp Leu Lys Leu Asp
        675                 680                 685             
Asn Leu Leu Leu Asp Ala Gln Gly Phe Leu Lys Ile Ala Asp Phe Gly
    690                 695                 700                 
Leu Cys Lys Glu Gly Ile Gly Phe Gly Asp Arg Thr Ser Thr Phe Cys
705                 710                 715                 720 
Gly Thr Pro Glu Phe Leu Ala Pro Glu Val Leu Thr Gln Glu Ala Tyr
                725                 730                 735     
Thr Gln Ala Val Asp Trp Trp Ala Leu Gly Val Leu Leu Tyr Glu Met
            740                 745                 750         
Leu Val Gly Glu Cys Pro Phe Pro Gly Asp Thr Glu Glu Glu Val Phe
        755                 760                 765             
Asp Cys Ile Val Asn Met Asp Ala Pro Tyr Pro Gly Phe Leu Ser Val
    770                 775                 780                 
Gln Gly Leu Glu Phe Ile Gln Lys Leu Leu Gln Lys Cys Pro Glu Lys
785                 790                 795                 800 
Arg Leu Gly Ala Gly Glu Gln Asp Ala Glu Glu Ile Lys Val Gln Pro
                805                 810                 815     
Phe Phe Arg Thr Thr Asn Trp Gln Ala Leu Leu Ala Arg Thr Ile Gln
            820                 825                 830         
Pro Pro Phe Val Pro Thr Leu Cys Gly Pro Ala Asp Leu Arg Tyr Phe
        835                 840                 845             
Glu Gly Glu Phe Thr Gly Leu Pro Pro Ala Leu Thr Pro Pro Ala Pro
    850                 855                 860                 
His Ser Leu Leu Thr Ala Arg Gln Gln Ala Ala Phe Arg Asp Phe Asp
865                 870                 875                 880 
Phe Val Ser Glu Arg Phe Leu Glu Pro
                885                 


<210> 8090
<211> 231
<212> PRT
<213> Homo sapiens

<400> 8090
Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp
 1               5                  10                  15      
Asp Ile Lys Arg Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu
            20                  25                  30          
Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Tyr Lys Trp
        35                  40                  45              
Val Pro Val Thr Glu Pro Lys Val Asp Asp Lys Asn Lys Asn Lys Lys
    50                  55                  60                  
Lys Gly Lys Asp Glu Lys Cys Gly Ser Glu Val Thr Thr Pro Glu Asn
65                  70                  75                  80  
Ser Ser Ser Pro Gly Met Met Asp Met His Asp Asp Asn Ser Asn Gln
                85                  90                  95      
Ser Ser Ile Ala Asp Ala Ser Pro Ile Lys Gln Glu Asn Ser Ser Asn
            100                 105                 110         
Ser Ser Pro Ala Pro Glu Pro Asn Ser Ala Val Pro Ser Asp Gly Thr
        115                 120                 125             
Glu Ala Lys Val Asp Glu Ala Gln Ala Asp Gly Lys Glu His Pro Gly
    130                 135                 140                 
Ala Glu Asp Ala Ser Asp Glu Gln Asn Ser Gln Ser Ser Met Glu His
145                 150                 155                 160 
Ser Met Asn Ser Ser Glu Lys Val Asp Arg Gln Pro Ser Gly Asp Ser
                165                 170                 175     
Gly Leu Ala Ala Glu Thr Ser Ala Ile Ser Gln Val Pro Arg Ser Arg
            180                 185                 190         
Ser Gln Arg Gly Ser Gln Ile Gly Arg Glu Pro Ile Gly Leu Ser Gly
        195                 200                 205             
Asp Leu Glu Gly Val Pro Pro Ser Lys Lys Met Lys Leu Glu Ala Ser
    210                 215                 220                 
Gln Gln Asn Ser Glu Glu Met
225                 230     


<210> 8091
<211> 1582
<212> PRT
<213> Homo sapiens

<400> 8091
Met Ala Gly Pro Gly Gly Trp Arg Asp Arg Glu Val Thr Asp Leu Gly
 1               5                  10                  15      
His Leu Pro Asp Pro Thr Gly Ile Phe Ser Leu Asp Lys Thr Ile Gly
            20                  25                  30          
Leu Gly Thr Tyr Gly Arg Ile Tyr Leu Gly Leu His Glu Lys Thr Gly
        35                  40                  45              
Ala Phe Thr Ala Val Lys Val Met Asn Ala Arg Lys Thr Pro Leu Pro
    50                  55                  60                  
Glu Ile Gly Arg Arg Val Arg Val Asn Lys Tyr Gln Lys Ser Val Gly
65                  70                  75                  80  
Trp Arg Tyr Ser Asp Glu Glu Glu Asp Leu Arg Thr Glu Leu Asn Leu
                85                  90                  95      
Leu Arg Lys Tyr Ser Phe His Lys Asn Ile Val Ser Phe Tyr Gly Ala
            100                 105                 110         
Phe Phe Lys Leu Ser Pro Pro Gly Gln Arg His Gln Leu Trp Met Val
        115                 120                 125             
Met Glu Leu Cys Ala Ala Gly Ser Val Thr Asp Val Val Arg Met Thr
    130                 135                 140                 
Ser Asn Gln Ser Leu Lys Glu Gly Trp Ile Ala Tyr Ile Cys Arg Glu
145                 150                 155                 160 
Ile Leu Gln Gly Leu Ala His Leu His Ala His Arg Val Ile His Arg
                165                 170                 175     
Asp Ile Lys Gly Gln Asn Val Leu Leu Thr His Asn Ala Glu Val Lys
            180                 185                 190         
Leu Val Asp Phe Gly Val Ser Ala Gln Val Ser Arg Thr Asn Gly Arg
        195                 200                 205             
Arg Asn Ser Phe Ile Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Ile
    210                 215                 220                 
Asp Cys Asp Glu Asp Pro Arg Arg Ser Tyr Asp Tyr Arg Ser Asp Val
225                 230                 235                 240 
Trp Ser Val Gly Ile Thr Ala Ile Glu Met Ala Glu Gly Ala Pro Pro
                245                 250                 255     
Leu Cys Asn Leu Gln Pro Leu Glu Ala Leu Phe Val Ile Leu Arg Glu
            260                 265                 270         
Ser Ala Pro Thr Val Lys Ser Ser Gly Trp Ser Arg Lys Phe His Asn
        275                 280                 285             
Phe Met Glu Lys Cys Thr Ile Lys Asn Phe Leu Phe Arg Pro Thr Ser
    290                 295                 300                 
Ala Asn Met Leu Gln His Pro Phe Val Arg Asp Ile Lys Asn Glu Arg
305                 310                 315                 320 
His Val Val Glu Ser Leu Thr Arg His Leu Thr Gly Ile Ile Lys Lys
                325                 330                 335     
Arg Gln Lys Lys Gly Ile Pro Leu Ile Phe Glu Arg Glu Glu Ala Ile
            340                 345                 350         
Lys Glu Gln Tyr Thr Val Arg Arg Phe Arg Gly Pro Ser Cys Thr His
        355                 360                 365             
Glu Leu Leu Arg Leu Pro Thr Ser Ser Arg Cys Arg Pro Leu Arg Val
    370                 375                 380                 
Leu His Gly Glu Pro Ser Gln Pro Arg Trp Leu Pro Asp Arg Glu Glu
385                 390                 395                 400 
Pro Gln Val Gln Ala Leu Gln Gln Leu Gln Gly Ala Ala Arg Val Phe
                405                 410                 415     
Met Pro Leu Gln Ala Leu Asp Ser Ala Pro Lys Pro Leu Lys Gly Gln
            420                 425                 430         
Ala Gln Ala Pro Gln Arg Leu Gln Gly Ala Ala Arg Val Phe Met Pro
        435                 440                 445             
Leu Gln Ala Gln Val Lys Ala Lys Ala Ser Lys Pro Leu Gln Met Gln
    450                 455                 460                 
Ile Lys Ala Pro Pro Arg Leu Arg Arg Ala Ala Arg Val Leu Met Pro
465                 470                 475                 480 
Leu Gln Ala Gln Val Arg Ala Pro Arg Leu Leu Gln Val Gln Ser Gln
                485                 490                 495     
Val Ser Lys Lys Gln Gln Ala Gln Thr Gln Thr Ser Glu Pro Gln Asp
            500                 505                 510         
Leu Asp Gln Val Pro Glu Glu Phe Gln Ser Gln Asp Gln Val Pro Glu
        515                 520                 525             
Gln Gln Arg Gln Gly Gln Ala Pro Glu Gln Gln Gln Arg His Asn Gln
    530                 535                 540                 
Val Pro Glu Gln Glu Leu Glu Gln Asn Gln Ala Pro Glu Gln Pro Glu
545                 550                 555                 560 
Val Gln Glu Gln Ala Ala Glu Pro Ala Gln Ala Gly Thr Glu Ala Glu
                565                 570                 575     
Glu Pro Glu Ser Leu Arg Val Asn Ala Gln Val Phe Leu Pro Leu Leu
            580                 585                 590         
Ser Gln Asp His His Val Leu Leu Pro Leu His Leu Asp Thr Gln Val
        595                 600                 605             
Leu Ile Pro Val Glu Gly Gln Thr Glu Gly Ser Pro Gln Ala Gln Ala
    610                 615                 620                 
Trp Thr Leu Glu Pro Pro Gln Ala Ile Gly Ser Val Gln Ala Leu Ile
625                 630                 635                 640 
Glu Gly Leu Ser Arg Asp Leu Leu Arg Ala Pro Asn Ser Asn Asn Ser
                645                 650                 655     
Lys Pro Leu Gly Pro Leu Gln Thr Leu Met Glu Asn Leu Ser Ser Asn
            660                 665                 670         
Arg Phe Tyr Ser Gln Pro Glu Gln Ala Arg Glu Lys Lys Ser Lys Val
        675                 680                 685             
Ser Thr Leu Arg Gln Ala Leu Ala Lys Arg Leu Ser Pro Lys Arg Phe
    690                 695                 700                 
Gly Ala Lys Ser Ser Trp Arg Pro Glu Lys Leu Glu Leu Ser Asp Leu
705                 710                 715                 720 
Glu Ala Arg Arg Gln Arg Arg Gln Arg Arg Trp Glu Asp Ile Phe Asn
                725                 730                 735     
Gln His Glu Glu Glu Leu Arg Gln Val Asp Lys Asp Lys Glu Asp Glu
            740                 745                 750         
Ser Ser Asp Asn Asp Glu Val Phe His Ser Ile Gln Ala Glu Val Gln
        755                 760                 765             
Ile Glu Pro Leu Lys Pro Tyr Ile Ser Asn Pro Lys Lys Ile Glu Val
    770                 775                 780                 
Gln Glu Arg Ser Pro Ser Val Pro Asn Asn Gln Asp His Ala His His
785                 790                 795                 800 
Val Lys Phe Ser Ser Ser Val Pro Gln Arg Ser Leu Leu Glu Gln Ala
                805                 810                 815     
Gln Lys Pro Ile Asp Ile Arg Gln Arg Ser Ser Gln Asn Arg Gln Asn
            820                 825                 830         
Trp Leu Ala Ala Ser Glu Ser Ser Ser Glu Glu Glu Ser Pro Val Thr
        835                 840                 845             
Gly Arg Arg Ser Gln Ser Ser Pro Pro Tyr Ser Thr Ile Asp Gln Lys
    850                 855                 860                 
Leu Leu Val Asp Ile His Val Pro Asp Gly Phe Lys Val Gly Lys Ile
865                 870                 875                 880 
Ser Pro Pro Val Tyr Leu Thr Asn Glu Trp Val Gly Tyr Asn Ala Leu
                885                 890                 895     
Ser Glu Ile Phe Arg Asn Asp Trp Leu Thr Pro Ala Pro Val Ile Gln
            900                 905                 910         
Pro Pro Glu Glu Asp Gly Asp Tyr Val Glu Leu Tyr Asp Ala Ser Ala
        915                 920                 925             
Asp Thr Asp Gly Asp Asp Asp Asp Glu Ser Asn Asp Thr Phe Glu Asp
    930                 935                 940                 
Thr Tyr Asp His Ala Asn Gly Asn Asp Asp Leu Asp Asn Gln Val Asp
945                 950                 955                 960 
Gln Ala Asn Asp Val Cys Lys Asp His Asp Asp Asp Asn Asn Lys Phe
                965                 970                 975     
Val Asp Asp Val Asn Asn Asn Tyr Tyr Glu Ala Pro Ser Cys Pro Arg
            980                 985                 990         
Ala Ser Tyr Gly Arg Asp Gly Ser Cys Lys Gln Asp Gly Tyr Asp Gly
        995                 1000                1005            
Ser Arg Gly Lys Glu Glu Ala Tyr Arg Gly Tyr Gly Ser His Thr Ala
    1010                1015                1020                
Asn Arg Ser His Gly Gly Ser Ala Ala Ser Glu Asp Asn Ala Ala Ile
1025                1030                1035                1040
Gly Asp Gln Glu Glu His Ala Ala Asn Ile Gly Ser Glu Arg Arg Gly
                1045                1050                1055    
Ser Glu Gly Asp Gly Gly Lys Gly Val Val Arg Thr Ser Glu Glu Ser
            1060                1065                1070        
Gly Ala Leu Gly Leu Asn Gly Glu Glu Asn Cys Ser Glu Thr Asp Gly
        1075                1080                1085            
Pro Gly Leu Lys Arg Pro Ala Ser Gln Asp Phe Glu Tyr Leu Gln Glu
    1090                1095                1100                
Glu Pro Gly Gly Gly Asn Glu Ala Ser Asn Ala Ile Asp Ser Gly Ala
1105                1110                1115                1120
Ala Pro Ser Ala Pro Asp His Glu Ser Asp Asn Lys Asp Ile Ser Glu
                1125                1130                1135    
Ser Pro Thr Gln Ser Asp Phe Ser Ala Asn His Ser Ser Pro Ser Lys
            1140                1145                1150        
Gly Ser Gly Met Ser Ala Asp Ala Asn Phe Ala Ser Ala Ile Leu Tyr
        1155                1160                1165            
Ala Gly Phe Val Glu Val Pro Glu Glu Ser Pro Lys Gln Pro Ser Glu
    1170                1175                1180                
Val Asn Val Asn Pro Leu Tyr Val Ser Pro Ala Cys Lys Lys Pro Leu
1185                1190                1195                1200
Ile His Met Tyr Glu Lys Glu Phe Thr Ser Glu Ile Cys Cys Gly Ser
                1205                1210                1215    
Leu Trp Gly Val Asn Leu Leu Leu Gly Thr Arg Ser Asn Leu Tyr Leu
            1220                1225                1230        
Met Asp Arg Ser Gly Lys Ala Asp Ile Thr Lys Leu Ile Arg Arg Arg
        1235                1240                1245            
Pro Phe Arg Gln Ile Gln Val Leu Glu Pro Leu Asn Leu Leu Ile Thr
    1250                1255                1260                
Ile Ser Gly His Lys Asn Arg Leu Arg Val Tyr His Leu Thr Trp Leu
1265                1270                1275                1280
Arg Asn Lys Ile Leu Asn Asn Asp Pro Glu Ser Lys Arg Arg Gln Glu
                1285                1290                1295    
Glu Met Leu Lys Thr Glu Glu Ala Cys Lys Ala Ile Asp Lys Leu Thr
            1300                1305                1310        
Gly Cys Glu His Phe Ser Val Leu Gln His Glu Glu Thr Thr Tyr Ile
        1315                1320                1325            
Ala Ile Ala Leu Lys Ser Ser Ile His Leu Tyr Ala Trp Ala Pro Lys
    1330                1335                1340                
Ser Phe Asp Glu Ser Thr Ala Ile Lys Val Cys Ile Asp Gln Ser Ala
1345                1350                1355                1360
Asp Ser Glu Gly Asp Tyr Met Ser Tyr Gln Ala Tyr Ile Arg Ile Leu
                1365                1370                1375    
Ala Lys Ile Gln Ala Ala Asp Pro Val Asn Arg Phe Lys Arg Pro Asp
            1380                1385                1390        
Glu Leu Leu His Leu Leu Lys Leu Lys Val Phe Pro Thr Leu Asp His
        1395                1400                1405            
Lys Pro Val Thr Val Asp Leu Ala Ile Gly Ser Glu Lys Arg Leu Lys
    1410                1415                1420                
Ile Phe Phe Ser Ser Ala Asp Gly Tyr His Leu Ile Asp Ala Glu Ser
1425                1430                1435                1440
Glu Val Met Ser Asp Val Thr Leu Pro Lys Asn Pro Leu Glu Ile Ile
                1445                1450                1455    
Ile Pro Gln Asn Ile Ile Ile Leu Pro Asp Cys Leu Gly Ile Gly Met
            1460                1465                1470        
Met Leu Thr Phe Asn Ala Glu Ala Leu Ser Val Glu Ala Asn Glu Gln
        1475                1480                1485            
Leu Phe Lys Lys Ile Leu Glu Met Trp Lys Asp Ile Pro Ser Ser Ile
    1490                1495                1500                
Ala Phe Glu Cys Thr Gln Arg Thr Thr Gly Trp Gly Gln Lys Ala Ile
1505                1510                1515                1520
Glu Val Arg Ser Leu Gln Ser Arg Val Leu Glu Ser Glu Leu Lys Arg
                1525                1530                1535    
Arg Ser Ile Lys Lys Leu Arg Phe Leu Cys Thr Arg Gly Asp Lys Leu
            1540                1545                1550        
Phe Phe Thr Ser Thr Leu Arg Asn His His Ser Arg Val Tyr Phe Met
        1555                1560                1565            
Thr Leu Gly Lys Leu Glu Glu Leu Gln Ser Asn Tyr Asp Val
    1570                1575                1580        


<210> 8092
<211> 620
<212> PRT
<213> Homo sapiens

<400> 8092
Asp Glu Glu Glu Asp Leu Arg Thr Glu Leu Asn Leu Leu Arg Lys Tyr
 1               5                  10                  15      
Ser Phe His Lys Asn Ile Val Ser Phe Tyr Gly Ala Phe Phe Lys Leu
            20                  25                  30          
Ser Pro Pro Gly Gln Arg His Gln Leu Trp Met Val Met Glu Leu Cys
        35                  40                  45              
Ala Ala Gly Ser Val Thr Asp Val Val Arg Met Thr Ser Asn Gln Ser
    50                  55                  60                  
Leu Lys Glu Asp Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Gln Gly
65                  70                  75                  80  
Leu Ala His Leu His Ala His Arg Val Ile His Arg Asp Ile Lys Gly
                85                  90                  95      
Gln Asn Val Leu Leu Thr His Asn Ala Glu Val Lys Leu Val Asp Phe
            100                 105                 110         
Gly Val Ser Ala Gln Val Ser Arg Thr Asn Gly Arg Arg Asn Ser Phe
        115                 120                 125             
Ile Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Ile Asp Cys Asp Glu
    130                 135                 140                 
Asp Pro Arg Arg Ser Tyr Asp Tyr Arg Ser Asp Val Trp Ser Val Gly
145                 150                 155                 160 
Ile Thr Ala Ile Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asn Leu
                165                 170                 175     
Gln Pro Leu Glu Ala Leu Phe Val Ile Leu Arg Glu Ser Ala Pro Thr
            180                 185                 190         
Val Lys Ser Ser Gly Trp Ser Arg Lys Phe His Asn Phe Met Glu Lys
        195                 200                 205             
Cys Thr Ile Lys Asn Phe Leu Phe Arg Pro Thr Ser Ala Asn Met Leu
    210                 215                 220                 
Gln His Pro Phe Val Arg Asp Ile Lys Asn Glu Arg His Val Val Glu
225                 230                 235                 240 
Ser Leu Thr Arg His Leu Thr Gly Ile Ile Lys Lys Arg Gln Lys Lys
                245                 250                 255     
Val Leu His Gly Glu Pro Ser Gln Pro Arg Trp Leu Pro Asp Arg Glu
            260                 265                 270         
Glu Pro Gln Val Gln Ala Leu Gln Gln Leu Gln Gly Ala Ala Arg Val
        275                 280                 285             
Phe Met Pro Leu Gln Ala Leu Asp Ser Ala Pro Lys Pro Leu Lys Gly
    290                 295                 300                 
Gln Ala Gln Ala Pro Gln Arg Leu Gln Gly Ala Ala Arg Val Phe Met
305                 310                 315                 320 
Pro Leu Gln Ala Gln Val Lys Ala Lys Ala Ser Lys Pro Leu Gln Met
                325                 330                 335     
Gln Ile Lys Ala Pro Pro Arg Leu Arg Arg Ala Ala Arg Val Leu Met
            340                 345                 350         
Pro Leu Gln Ala Gln Val Arg Ala Pro Arg Leu Leu Gln Val Gln Ser
        355                 360                 365             
Gln Val Ser Lys Lys Gln Gln Ala Gln Thr Gln Thr Ser Glu Pro Gln
    370                 375                 380                 
Asp Leu Asp Gln Val Pro Glu Glu Phe Gln Gly Gln Asp Gln Val Pro
385                 390                 395                 400 
Glu Gln Gln Arg Gln Gly Gln Ala Pro Glu Gln Gln Gln Arg His Asn
                405                 410                 415     
Gln Val Pro Glu Gln Glu Leu Glu Gln Asn Gln Ala Pro Glu Gln Pro
            420                 425                 430         
Glu Val Gln Glu Gln Ala Ala Glu Pro Ala Gln Ala Glu Thr Glu Ala
        435                 440                 445             
Glu Glu Pro Glu Ser Leu Arg Val Asn Ala Gln Val Phe Leu Pro Leu
    450                 455                 460                 
Leu Ser Gln Asp His His Val Leu Leu Pro Leu His Leu Asp Thr Gln
465                 470                 475                 480 
Val Leu Ile Pro Val Glu Gly Gln Thr Glu Gly Ser Pro Gln Ala Gln
                485                 490                 495     
Ala Trp Thr Leu Glu Pro Pro Gln Ala Ile Gly Ser Val Gln Ala Leu
            500                 505                 510         
Ile Glu Gly Leu Ser Arg Asp Leu Leu Arg Ala Pro Asn Ser Asn Asn
        515                 520                 525             
Ser Lys Pro Leu Gly Pro Leu Gln Thr Leu Met Glu Asn Leu Ser Ser
    530                 535                 540                 
Asn Arg Phe Tyr Ser Gln Pro Glu Gln Ala Arg Glu Lys Lys Ser Lys
545                 550                 555                 560 
Val Ser Thr Leu Arg Gln Ala Leu Ala Lys Arg Leu Ser Pro Lys Arg
                565                 570                 575     
Phe Arg Ala Lys Ser Ser Trp Arg Pro Glu Lys Leu Glu Leu Ser Asp
            580                 585                 590         
Leu Glu Ala Arg Arg Gln Arg Arg Gln Arg Arg Trp Glu Asp Ile Phe
        595                 600                 605             
Asn Gln His Glu Glu Glu Leu Arg Gln Val Asp Lys
    610                 615                 620 


<210> 8093
<211> 1534
<212> PRT
<213> Homo sapiens

<400> 8093
Met Ala Gly Pro Gly Gly Trp Arg Asp Arg Glu Val Thr Asp Leu Gly
 1               5                  10                  15      
His Leu Pro Asp Pro Thr Gly Ile Phe Ser Leu Asp Lys Thr Ile Gly
            20                  25                  30          
Leu Gly Thr Tyr Gly Arg Ile Tyr Leu Gly Leu His Glu Lys Thr Gly
        35                  40                  45              
Ala Phe Thr Ala Val Lys Val Met Asn Ala Arg Lys Thr Pro Leu Pro
    50                  55                  60                  
Glu Ile Gly Arg Arg Val Arg Val Asn Lys Tyr Gln Lys Ser Val Gly
65                  70                  75                  80  
Trp Arg Tyr Ser Asp Glu Glu Glu Asp Leu Arg Thr Glu Leu Asn Leu
                85                  90                  95      
Leu Arg Lys Tyr Ser Phe His Lys Asn Ile Val Ser Phe Tyr Gly Ala
            100                 105                 110         
Phe Phe Lys Leu Ser Pro Pro Gly Gln Arg His Gln Leu Trp Met Val
        115                 120                 125             
Met Glu Leu Cys Ala Ala Gly Ser Val Thr Asp Val Val Arg Met Thr
    130                 135                 140                 
Ser Asn Gln Ser Leu Lys Glu Asp Trp Ile Ala Tyr Ile Cys Arg Glu
145                 150                 155                 160 
Ile Leu Gln Gly Leu Ala His Leu His Ala His Arg Val Ile His Arg
                165                 170                 175     
Asp Ile Lys Gly Gln Asn Val Leu Leu Thr His Asn Ala Glu Val Lys
            180                 185                 190         
Leu Val Asp Phe Gly Val Ser Ala Gln Val Ser Arg Thr Asn Gly Arg
        195                 200                 205             
Arg Asn Ser Phe Ile Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Ile
    210                 215                 220                 
Asp Cys Asp Glu Asp Pro Arg Arg Ser Tyr Asp Tyr Arg Ser Asp Val
225                 230                 235                 240 
Trp Ser Val Gly Ile Thr Ala Ile Glu Met Ala Glu Gly Ala Pro Pro
                245                 250                 255     
Leu Cys Asn Leu Gln Pro Leu Glu Ala Leu Phe Val Ile Leu Arg Glu
            260                 265                 270         
Ser Ala Pro Thr Val Lys Ser Ser Gly Trp Ser Arg Lys Phe His Asn
        275                 280                 285             
Phe Met Glu Lys Cys Thr Ile Lys Asn Phe Leu Phe Arg Pro Thr Ser
    290                 295                 300                 
Ala Asn Met Leu Gln His Pro Phe Val Arg Asp Ile Lys Asn Glu Arg
305                 310                 315                 320 
His Val Val Glu Ser Leu Thr Arg His Leu Thr Gly Ile Ile Lys Lys
                325                 330                 335     
Arg Gln Lys Lys Gly Ile Pro Leu Ile Phe Glu Arg Glu Glu Ala Ile
            340                 345                 350         
Lys Glu Gln Tyr Thr Val Arg Arg Phe Arg Gly Pro Ser Cys Thr His
        355                 360                 365             
Glu Leu Leu Arg Leu Pro Thr Ser Ser Arg Cys Arg Pro Leu Arg Val
    370                 375                 380                 
Leu His Gly Glu Pro Ser Gln Pro Arg Trp Leu Pro Asp Arg Glu Glu
385                 390                 395                 400 
Pro Gln Val Gln Ala Leu Gln Gln Leu Gln Gly Ala Ala Arg Val Phe
                405                 410                 415     
Met Pro Leu Gln Ala Leu Asp Ser Ala Pro Lys Pro Leu Lys Gly Gln
            420                 425                 430         
Ala Gln Ala Pro Gln Arg Leu Gln Gly Ala Ala Arg Val Phe Met Pro
        435                 440                 445             
Leu Gln Ala Gln Val Lys Ala Lys Ala Ser Lys Pro Leu Gln Met Gln
    450                 455                 460                 
Ile Lys Ala Pro Pro Arg Leu Arg Arg Ala Ala Arg Val Leu Met Pro
465                 470                 475                 480 
Leu Gln Ala Gln Val Arg Ala Pro Arg Leu Leu Gln Val Gln Ser Gln
                485                 490                 495     
Val Ser Lys Lys Gln Gln Ala Gln Thr Gln Thr Ser Glu Pro Gln Asp
            500                 505                 510         
Leu Asp Gln Val Pro Glu Glu Phe Gln Gly Gln Asp Gln Val Pro Glu
        515                 520                 525             
Gln Gln Arg Gln Gly Gln Ala Pro Glu Gln Gln Gln Arg His Asn Gln
    530                 535                 540                 
Val Pro Glu Gln Glu Leu Glu Gln Asn Gln Ala Pro Glu Gln Pro Glu
545                 550                 555                 560 
Val Gln Glu Gln Ala Ala Glu Pro Ala Gln Ala Glu Thr Glu Ala Glu
                565                 570                 575     
Glu Pro Glu Ser Leu Arg Val Asn Ala Gln Val Phe Leu Pro Leu Leu
            580                 585                 590         
Ser Gln Asp His His Val Leu Leu Pro Leu His Leu Asp Thr Gln Val
        595                 600                 605             
Leu Ile Pro Val Glu Gly Gln Thr Glu Gly Ser Pro Gln Ala Gln Ala
    610                 615                 620                 
Trp Thr Leu Glu Pro Pro Gln Ala Ile Gly Ser Val Gln Ala Leu Ile
625                 630                 635                 640 
Glu Gly Leu Ser Arg Asp Leu Leu Arg Ala Pro Asn Ser Asn Asn Ser
                645                 650                 655     
Lys Pro Leu Gly Pro Leu Gln Thr Leu Met Glu Asn Leu Ser Ser Asn
            660                 665                 670         
Arg Phe Tyr Ser Gln Pro Glu Gln Ala Arg Glu Lys Lys Ser Lys Val
        675                 680                 685             
Ser Thr Leu Arg Gln Ala Leu Ala Lys Arg Leu Ser Pro Lys Arg Phe
    690                 695                 700                 
Arg Ala Lys Ser Ser Trp Arg Pro Glu Lys Leu Glu Leu Ser Asp Leu
705                 710                 715                 720 
Glu Ala Arg Arg Gln Arg Arg Gln Arg Arg Trp Glu Asp Ile Phe Asn
                725                 730                 735     
Gln His Glu Glu Glu Leu Arg Gln Val Asp Lys Asp Lys Glu Asp Glu
            740                 745                 750         
Ser Ser Asp Asn Asp Glu Val Phe His Ser Ile Gln Ala Glu Val Gln
        755                 760                 765             
Ile Glu Pro Leu Lys Pro Tyr Ile Ser Asn Pro Lys Lys Ile Glu Val
    770                 775                 780                 
Gln Glu Arg Ser Pro Ser Val Pro Asn Asn Gln Asp His Ala His His
785                 790                 795                 800 
Val Lys Phe Ser Ser Ser Val Pro Gln Arg Ser Leu Leu Glu Gln Ala
                805                 810                 815     
Gln Lys Pro Ile Asp Ile Arg Gln Arg Ser Ser Gln Asn Arg Gln Asn
            820                 825                 830         
Trp Leu Ala Ala Ser Glu Ser Ser Ser Glu Glu Glu Ser Pro Val Thr
        835                 840                 845             
Gly Arg Arg Ser Gln Ser Ser Pro Pro Tyr Ser Thr Ile Asp Gln Lys
    850                 855                 860                 
Leu Leu Val Asp Ile His Val Pro Asp Gly Phe Lys Val Gly Lys Ile
865                 870                 875                 880 
Ser Pro Pro Val Tyr Leu Thr Asn Glu Trp Val Gly Tyr Asn Ala Leu
                885                 890                 895     
Ser Glu Ile Phe Arg Asn Asp Trp Leu Thr Pro Ala Pro Val Ile Gln
            900                 905                 910         
Pro Pro Glu Glu Asp Gly Asp Tyr Val Glu Leu Tyr Asp Ala Ser Ala
        915                 920                 925             
Asp Thr Asp Gly Asp Asp Asp Asp Glu Ser Asn Asp Thr Phe Glu Asp
    930                 935                 940                 
Thr Tyr Asp His Ala Asn Gly Asn Asp Asp Leu Asp Asn Gln Val Asp
945                 950                 955                 960 
Gln Ala Asn Asp Val Cys Lys Asp His Asp Asp Asp Asn Asn Lys Phe
                965                 970                 975     
Val Asp Asp Val Asn Asn Asn Tyr Tyr Glu Ala Pro Ser Cys Pro Arg
            980                 985                 990         
Ala Ser Tyr Gly Arg Asp Gly Ser Cys Lys Gln Asp Gly Tyr Asp Gly
        995                 1000                1005            
Ser Arg Gly Lys Glu Glu Ala Tyr Arg Gly Tyr Gly Ser His Thr Ala
    1010                1015                1020                
Asn Arg Ser His Gly Gly Ser Ala Ala Ser Glu Asp Asn Ala Ala Ile
1025                1030                1035                1040
Gly Asp Gln Glu Glu His Ala Ala Asn Ile Gly Ser Glu Arg Arg Gly
                1045                1050                1055    
Ser Glu Gly Asp Gly Gly Lys Gly Val Val Arg Thr Ser Glu Glu Ser
            1060                1065                1070        
Gly Ala Leu Gly Leu Asn Gly Glu Glu Asn Cys Ser Glu Thr Asp Gly
        1075                1080                1085            
Pro Gly Leu Lys Arg Pro Ala Ser Gln Asp Phe Glu Tyr Leu Gln Glu
    1090                1095                1100                
Glu Pro Gly Gly Gly Asn Glu Ala Ser Asn Ala Ile Asp Ser Gly Ala
1105                1110                1115                1120
Ala Pro Ser Ala Pro Asp His Glu Ser Asp Asn Lys Asp Ile Ser Glu
                1125                1130                1135    
Ser Ser Thr Gln Ser Asp Phe Ser Ala Asn His Ser Ser Pro Ser Lys
            1140                1145                1150        
Gly Ser Gly Met Ser Ala Asp Ala Asn Phe Ala Ser Ala Ile Leu Tyr
        1155                1160                1165            
Ala Gly Phe Val Glu Val Pro Glu Glu Ser Pro Lys Gln Pro Ser Glu
    1170                1175                1180                
Val Asn Val Asn Pro Leu Tyr Val Ser Pro Ala Cys Lys Lys Pro Leu
1185                1190                1195                1200
Ile His Met Tyr Glu Lys Glu Phe Thr Ser Glu Ile Cys Cys Gly Ser
                1205                1210                1215    
Leu Trp Gly Val Asn Leu Leu Leu Gly Thr Arg Ser Asn Leu Tyr Leu
            1220                1225                1230        
Met Asp Arg Ser Gly Lys Ala Asp Ile Thr Lys Leu Ile Arg Arg Arg
        1235                1240                1245            
Pro Phe Arg Gln Ile Gln Val Leu Glu Pro Leu Asn Leu Leu Ile Thr
    1250                1255                1260                
Ile Ser Gly His Lys Asn Arg Leu Arg Val Tyr His Leu Thr Trp Leu
1265                1270                1275                1280
Arg Asn Lys Ile Leu Asn Asn Asp Pro Glu Ser Lys Arg Arg Gln Glu
                1285                1290                1295    
Glu Met Leu Lys Thr Glu Glu Ala Cys Lys Ala Ile Asp Lys Leu Thr
            1300                1305                1310        
Gly Cys Glu His Phe Ser Val Leu Gln His Glu Glu Thr Thr Tyr Ile
        1315                1320                1325            
Ala Ile Ala Leu Lys Ser Ser Ile His Leu Tyr Ala Trp Ala Pro Lys
    1330                1335                1340                
Ser Phe Asp Glu Ser Thr Ala Ile Lys Val Phe Pro Thr Leu Asp His
1345                1350                1355                1360
Lys Pro Val Thr Val Asp Leu Ala Ile Gly Ser Glu Lys Arg Leu Lys
                1365                1370                1375    
Ile Phe Phe Ser Ser Ala Asp Gly Tyr His Leu Ile Asp Ala Glu Ser
            1380                1385                1390        
Glu Val Met Ser Asp Val Thr Leu Pro Lys Asn Pro Leu Glu Ile Ile
        1395                1400                1405            
Ile Pro Gln Asn Ile Ile Ile Leu Pro Asp Cys Leu Gly Ile Gly Met
    1410                1415                1420                
Met Leu Thr Phe Asn Ala Glu Ala Leu Ser Val Glu Ala Asn Glu Gln
1425                1430                1435                1440
Leu Phe Lys Lys Ile Leu Glu Met Trp Lys Asp Ile Pro Ser Ser Ile
                1445                1450                1455    
Ala Phe Glu Cys Thr Gln Arg Thr Thr Gly Trp Gly Gln Lys Ala Ile
            1460                1465                1470        
Glu Val Arg Ser Leu Gln Ser Arg Val Leu Glu Ser Glu Leu Lys Arg
        1475                1480                1485            
Arg Ser Ile Lys Lys Leu Arg Phe Leu Cys Thr Arg Gly Asp Lys Leu
    1490                1495                1500                
Phe Phe Thr Ser Thr Leu Arg Asn His His Ser Arg Val Tyr Phe Met
1505                1510                1515                1520
Thr Leu Gly Lys Leu Glu Glu Leu Gln Ser Asn Tyr Asp Val
                1525                1530                


<210> 8094
<211> 430
<212> PRT
<213> Homo sapiens

<400> 8094
Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu Met
 1               5                  10                  15      
Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu Glu
            20                  25                  30          
Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu Ile
        35                  40                  45              
Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu
    50                  55                  60                  
Ser Leu Lys Ser Glu Lys Thr Glu Asp Tyr Leu Arg Glu Ser Ile Ile
65                  70                  75                  80  
Gln Gln His Met Val Ser Pro Glu Pro Ala Ser Leu Lys Glu Lys Gly
                85                  90                  95      
Lys Ser Arg Arg Lys Lys Asp Gln Thr His Ala Cys Pro Asn Val Arg
            100                 105                 110         
Lys Ala Arg Pro Val Ser Tyr Asp Arg Thr Glu Pro Lys Asp Asp Asp
        115                 120                 125             
Val Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr
    130                 135                 140                 
Ile Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile
145                 150                 155                 160 
Gln Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val
                165                 170                 175     
Tyr Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp
            180                 185                 190         
Leu Gln Val Ile Asn Ile Val Gly Ser Val Lys Glu Val Glu Leu Ile
        195                 200                 205             
Pro Thr Leu Glu Trp Leu Ser Glu Arg Arg His Tyr Tyr Leu Leu Arg
    210                 215                 220                 
Gln Phe Lys Ile Phe Ser Asp Phe Arg Met Asn Lys Ala Phe Val Thr
225                 230                 235                 240 
Trp Lys Leu Asn Val Lys Arg Ile Lys Thr Glu Lys Ser Arg Ser Phe
                245                 250                 255     
Leu Tyr His His Leu Phe Leu Ala Asp Asp Leu Phe Gln Thr Cys Leu
            260                 265                 270         
Val Tyr Ile Arg Gly Leu Cys Glu Asp Ala Ile Asn Leu Lys Asn Tyr
        275                 280                 285             
Asn Asp His Glu Asn Asn Leu Ser Ala Ile Cys Leu Val Lys Leu Asp
    290                 295                 300                 
Ser Ser Arg Thr Tyr Ser Leu Asp Glu Phe Cys Glu Glu Gln Leu Gln
305                 310                 315                 320 
Gln Ala Thr Gln Ala Leu Lys Gln Leu Glu Asp Ile Arg Asn Lys Ala
                325                 330                 335     
Ile Ser Glu Met Lys Ser Thr Phe Leu Lys Val Ala Glu Lys Asn Glu
            340                 345                 350         
Ile Lys Glu Tyr Phe Glu Ser Lys Leu Ser Glu Asp Asp Thr Thr His
        355                 360                 365             
Phe Lys Leu Pro Lys Tyr Arg Arg Leu Leu Glu Thr Phe Phe Lys Phe
    370                 375                 380                 
Val Met Leu Val Asp Tyr Ile Phe Gln Glu Leu Ile Arg Gln Leu Met
385                 390                 395                 400 
Asn Thr Ala Val Thr Leu Leu Leu Glu Leu Phe Asn Gly Ser Ala Gly
                405                 410                 415     
Met Pro Phe Ser Val Glu Lys Lys Asn Glu Asn Leu Ile Arg
            420                 425                 430 


<210> 8095
<211> 657
<212> PRT
<213> Homo sapiens

<400> 8095
Met Ala Ser Ala Arg Lys Ala Ser Arg Pro Met Arg Asp Val Phe Gly
 1               5                  10                  15      
Asp Phe Ser Asp Val Ser Leu Glu Asp Ser Thr Met Glu Glu Ile Arg
            20                  25                  30          
Asn Phe Gln Ile Ser Arg Asn Leu Thr Lys Ile Ala Pro Gly His Ser
        35                  40                  45              
Arg Phe Leu Lys Arg Asn Gln Thr Leu Asp Glu Lys His Leu Leu Leu
    50                  55                  60                  
Lys Glu Asn Pro Val Leu Gly Ser Gly Pro Arg Leu Ala Ser Cys Arg
65                  70                  75                  80  
Pro Pro Thr Thr Ala Ser Arg Ile Arg Ala Asn Ala Ala Leu Met Lys
                85                  90                  95      
Leu Ala Gln Leu Glu Thr Arg Ile Met Asn Arg Lys Leu Gln Arg Asn
            100                 105                 110         
Leu Ser Asp Thr Glu Ser Asp Ser Met Thr Ala Asp Ala Gly Leu Pro
        115                 120                 125             
Lys Arg Ala Asp Arg Ile Leu Ser Gly Gly Ala Leu Glu Leu Ala Ser
    130                 135                 140                 
Gln Asn Thr Asp Lys Thr Ser Gln Asn Gln Ala Arg Glu Leu Pro Val
145                 150                 155                 160 
Thr Glu Asn Asn Ala Gln Asn Ala Lys Val Ser Arg Phe Leu Lys Lys
                165                 170                 175     
Lys Gln Ala Pro Val Glu Asn Ile Ser Pro Glu Ala Pro Ala Gly Lys
            180                 185                 190         
Glu Arg Thr Leu Gln Thr Pro Lys Gln Lys Glu Pro Ala Arg Thr Phe
        195                 200                 205             
Asp Ser Pro Asp Ser Asp Glu Glu Glu Met Lys Val Leu Leu Gly Ser
    210                 215                 220                 
Leu Met Asp Ser Ser Arg Glu Lys Asn Thr Asn Gln Gly Phe Ser Ser
225                 230                 235                 240 
Ala Asn Val Ser Glu Glu Glu Glu Arg Lys Leu Phe Ser Val Pro Ser
                245                 250                 255     
Gln Leu Arg Ala Phe Thr Val Pro Ser Val Glu Leu Ser Ser Ala Lys
            260                 265                 270         
Pro Ser Gln Thr Ser His Leu Pro Thr Ser Leu Ala Ala Asp Arg Thr
        275                 280                 285             
Leu His Ser Thr Arg Ser Arg Ala Asp Tyr Pro Gln Ser His Val Ser
    290                 295                 300                 
Ser Asp Thr Ala Ser His Thr Pro Ser Val Ser Ile Thr Gly Ala Phe
305                 310                 315                 320 
Ser Asn Ser Val Ser Leu Lys Met Gly His Val Lys Leu Val Ser Ser
                325                 330                 335     
Pro Gly Arg Ser Glu Ala Glu Thr Val Asp Glu Pro Val Ser Glu Gly
            340                 345                 350         
Ala Asp Asp Ser Leu Asp Glu Phe Arg Ile Asn Ile Leu Ser Leu Asp
        355                 360                 365             
Gly Leu Ala Pro Ala Val Ser Glu Asn Ser Asp Leu Glu Gln Glu Glu
    370                 375                 380                 
Glu Ser Ala Gln Arg Gln Lys Thr Ala Gly Lys Ile Phe Arg Ala Glu
385                 390                 395                 400 
Ala Ser Thr Gly Gln Asp Ala Pro Arg Gln Ala Gln Ala Arg Ser Trp
                405                 410                 415     
Ala Ser Gln Gly Lys Ala Ala Ser Ala Glu Gly Asp Glu Ser Glu Val
            420                 425                 430         
Ser Glu His Leu Ser Ala Ser Ser Ala Ser Ala Ile Gln Gln Asp Ser
        435                 440                 445             
Thr Ser Ser Met Gln Pro Pro Ser Glu Ala Pro Met Val Asn Thr Val
    450                 455                 460                 
Ser Ser Ala Tyr Ser Glu Asp Phe Glu Asn Ser Pro Ser Leu Thr Ala
465                 470                 475                 480 
Ser Glu Pro Thr Ala His Ser Lys Glu Ser Leu Asp Arg Thr Leu Asp
                485                 490                 495     
Ala Leu Ser Glu Ser Ser Ser Ser Val Lys Thr Asp Leu Pro Gln Thr
            500                 505                 510         
Ala Glu Ser Arg Lys Lys Ser Gly Arg His Val Thr Arg Val Leu Val
        515                 520                 525             
Lys Asp Thr Ala Val Gln Thr Pro Asp Pro Ala Phe Thr Tyr Glu Trp
    530                 535                 540                 
Thr Lys Val Ala Ser Met Ala Ala Met Gly Pro Ala Leu Gly Gly Ala
545                 550                 555                 560 
Tyr Val Asp Pro Thr Pro Ile Ala Asn His Val Ile Ser Ala Asp Ala
                565                 570                 575     
Ile Glu Ala Leu Thr Ala Tyr Ser Pro Ala Val Leu Ala Leu His Asp
            580                 585                 590         
Val Leu Lys Gln Gln Leu Ser Leu Thr Gln Gln Phe Ile Gln Ala Ser
        595                 600                 605             
Arg His Leu His Ala Ser Leu Leu Arg Ser Leu Asp Ala Asp Ser Phe
    610                 615                 620                 
His Tyr His Thr Leu Glu Glu Ala Lys Glu Tyr Ile Arg Cys His Arg
625                 630                 635                 640 
Pro Ala Pro Leu Thr Met Glu Asp Ala Leu Glu Glu Val Asn Lys Glu
                645                 650                 655     
Leu
    


<210> 8096
<211> 618
<212> PRT
<213> Homo sapiens

<400> 8096
Met Ala Ser Ala Arg Lys Ala Ser Arg Pro Met Arg Asp Val Phe Gly
 1               5                  10                  15      
Asp Phe Ser Asp Val Ser Leu Glu Asp Ser Thr Met Glu Glu Ile Arg
            20                  25                  30          
Asn Phe Gln Ile Ser Arg Asn Leu Thr Lys Ile Ala Pro Gly His Ser
        35                  40                  45              
Arg Phe Leu Lys Arg Asn Gln Thr Leu Asp Glu Lys His Leu Leu Leu
    50                  55                  60                  
Lys Glu Asn Pro Val Leu Gly Ser Gly Pro Arg Leu Ala Ser Cys Arg
65                  70                  75                  80  
Pro Pro Thr Thr Ala Ser Arg Ile Arg Ala Asn Ala Ala Leu Met Lys
                85                  90                  95      
Leu Ala Gln Leu Glu Thr Arg Ile Met Asn Arg Lys Leu Gln Arg Asn
            100                 105                 110         
Leu Ser Asp Thr Glu Ser Asp Ser Met Thr Ala Asp Ala Gly Leu Pro
        115                 120                 125             
Lys Arg Ala Asp Arg Ile Leu Ser Gly Gly Ala Leu Glu Leu Ala Ser
    130                 135                 140                 
Gln Asn Thr Asp Lys Thr Ser Gln Asn Gln Ala Arg Glu Leu Pro Val
145                 150                 155                 160 
Thr Glu Asn Asn Ala Gln Asn Ala Lys Val Ser Arg Phe Leu Lys Lys
                165                 170                 175     
Lys Gln Ala Pro Val Glu Asn Ile Ser Pro Glu Ala Pro Ala Gly Lys
            180                 185                 190         
Glu Arg Thr Leu Gln Thr Pro Lys Gln Lys Glu Pro Ala Arg Thr Phe
        195                 200                 205             
Asp Ser Pro Asp Ser Asp Glu Glu Glu Met Lys Val Leu Leu Gly Ser
    210                 215                 220                 
Leu Met Asp Ser Ser Arg Glu Lys Asn Thr Asn Gln Gly Phe Ser Ser
225                 230                 235                 240 
Ala Asn Val Ser Glu Glu Glu Glu Arg Lys Leu Phe Ser Val Pro Ser
                245                 250                 255     
Gln Leu Arg Ala Phe Thr Val Pro Ser Val Glu Leu Ser Ser Ala Lys
            260                 265                 270         
Pro Ser Gln Thr Ser His Leu Pro Thr Ser Leu Ala Ala Asp Arg Thr
        275                 280                 285             
Leu His Ser Thr Arg Ser Arg Ala Asp Tyr Pro Gln Ser His Val Ser
    290                 295                 300                 
Ser Asp Thr Ala Ser His Thr Pro Ser Val Ser Ile Thr Gly Ala Phe
305                 310                 315                 320 
Ser Asn Ser Val Ser Leu Lys Met Gly His Val Lys Leu Val Ser Ser
                325                 330                 335     
Pro Gly Arg Ser Glu Ala Glu Thr Val Asp Glu Pro Val Ser Glu Gly
            340                 345                 350         
Ala Asp Asp Ser Leu Asp Glu Phe Arg Ile Asn Ile Leu Ser Leu Asp
        355                 360                 365             
Gly Leu Ala Pro Ala Val Ser Glu Asn Ser Asp Leu Glu Gln Glu Glu
    370                 375                 380                 
Glu Ser Ala Gln Arg Gln Lys Thr Ala Gly Lys Ile Phe Arg Ala Glu
385                 390                 395                 400 
Ala Ser Thr Gly Gln Asp Ala Pro Arg Gln Ala Gln Ala Arg Ser Trp
                405                 410                 415     
Ala Ser Gln Gly Lys Ala Ala Ser Ala Glu Gly Asp Glu Ser Glu Val
            420                 425                 430         
Ser Glu His Leu Ser Ala Ser Ser Ala Ser Ala Ile Gln Gln Asp Ser
        435                 440                 445             
Thr Ser Ser Met Gln Pro Pro Ser Glu Ala Pro Met Val Asn Thr Val
    450                 455                 460                 
Ser Ser Ala Tyr Ser Glu Asp Phe Glu Asn Ser Pro Ser Leu Thr Ala
465                 470                 475                 480 
Ser Glu Pro Thr Ala His Ser Lys Glu Ser Leu Asp Arg Thr Leu Asp
                485                 490                 495     
Ala Leu Ser Glu Ser Ser Ser Ser Val Lys Thr Asp Leu Pro Gln Thr
            500                 505                 510         
Ala Glu Ser Arg Lys Lys Ser Gly Arg His Val Thr Arg Val Leu Val
        515                 520                 525             
Lys Asp Thr Ala Val Gln Thr Pro Asp Pro Ala Phe Thr Tyr Glu Trp
    530                 535                 540                 
Thr Lys Val Ala Ser Met Ala Ala Met Gly Pro Ala Leu Gly Gly Ala
545                 550                 555                 560 
Tyr Val Asp Pro Thr Pro Ile Ala Asn His Val Ile Ser Ala Asp Ala
                565                 570                 575     
Ile Glu Ala Ala Glu Pro Asp Ala Ala Val His Pro Gly Gln Pro Ala
            580                 585                 590         
Pro Ala Arg Leu Pro Pro Ala Leu Pro Gly Arg Gly Leu Leu Pro Leu
        595                 600                 605             
Pro His Pro Gly Gly Ser Gln Arg Val His
    610                 615             


<210> 8097
<211> 1347
<212> PRT
<213> Homo sapiens

<400> 8097
Met Ala Glu Pro Arg Arg Val Ala Phe Ile Ser Leu Ser Pro Val Arg
 1               5                  10                  15      
Arg Arg Glu Ala Glu Tyr Pro Gly Pro Glu Arg Glu Pro Glu Tyr Pro
            20                  25                  30          
Arg Glu Pro Pro Arg Leu Glu Pro Gln Pro Tyr Arg Glu Pro Ala Arg
        35                  40                  45              
Ala Glu Pro Pro Ala Pro Arg Glu Pro Ala Pro Arg Ser Asp Ala Gln
    50                  55                  60                  
Pro Pro Ser Arg Glu Lys Pro Leu Pro Gln Arg Glu Val Ser Arg Ala
65                  70                  75                  80  
Glu Pro Pro Met Ser Leu Gln Arg Glu Pro Pro Arg Pro Glu Pro Pro
                85                  90                  95      
Pro Pro Phe Pro Pro Leu Pro Leu Gln Pro Pro Pro Pro Arg Glu Ser
            100                 105                 110         
Ala Ser Arg Ala Glu Gln Pro Pro Arg Pro Pro Arg Glu Thr Val Arg
        115                 120                 125             
Leu Glu Leu Val Leu Lys Asp Pro Thr Asp Glu Ser Cys Val Glu Phe
    130                 135                 140                 
Ser Tyr Pro Glu Leu Leu Leu Cys Gly Glu Gln Arg Lys Lys Leu Ile
145                 150                 155                 160 
His Thr Glu Asp Pro Phe Asn Asp Glu His Gln Glu Arg Gln Glu Val
                165                 170                 175     
Glu Met Leu Ala Lys Lys Phe Glu Met Lys Tyr Gly Gly Lys Pro Arg
            180                 185                 190         
Lys His Arg Lys Asp Arg Leu Gln Asp Leu Ile Asp Ile Gly Phe Gly
        195                 200                 205             
Tyr Asp Glu Thr Asp Pro Phe Ile Asp Asn Ser Glu Ala Tyr Asp Glu
    210                 215                 220                 
Leu Val Pro Ala Ser Leu Thr Thr Lys Tyr Gly Gly Phe Tyr Ile Asn
225                 230                 235                 240 
Thr Gly Thr Leu Gln Phe Arg Gln Ala Ser Asp Thr Glu Glu Asp Asp
                245                 250                 255     
Ile Thr Asp Asn Gln Lys His Lys Pro Pro Lys Val Pro Lys Ile Lys
            260                 265                 270         
Glu Asp Asp Ile Glu Met Lys Lys Arg Lys Arg Lys Glu Glu Gly Glu
        275                 280                 285             
Lys Glu Lys Lys Pro Arg Lys Lys Val Pro Lys Gln Leu Gly Val Val
    290                 295                 300                 
Ala Leu Asn Ser His Lys Ser Glu Lys Lys Lys Lys Arg Tyr Lys Asp
305                 310                 315                 320 
Ser Leu Ser Leu Ala Ala Met Ile Arg Lys Phe Gln Lys Glu Lys Asp
                325                 330                 335     
Ala Leu Lys Lys Glu Ser Asn Pro Lys Val Pro Val Thr Leu Ser Thr
            340                 345                 350         
Pro Ser Leu Asn Lys Pro Pro Cys Ala Ala Ala Ala Leu Gly Asn Asp
        355                 360                 365             
Val Pro Asp Leu Asn Leu Ser Ser Gly Asp Pro Asp Leu Pro Ile Phe
    370                 375                 380                 
Val Ser Thr Asn Glu His Glu Leu Phe Gln Glu Ala Glu Asn Ala Leu
385                 390                 395                 400 
Glu Met Leu Asp Asp Phe Asp Phe Asp Arg Leu Leu Asp Ala Ala Ser
                405                 410                 415     
Asp Gly Ser Pro Leu Ser Glu Ser Gly Gly Glu Asn Gly Thr Thr Thr
            420                 425                 430         
Gln Pro Thr Tyr Thr Ser Gln Val Met Pro Lys Val Val Pro Thr Leu
        435                 440                 445             
Pro Glu Gly Leu Pro Val Leu Leu Glu Lys Arg Ile Glu Asp Leu Arg
    450                 455                 460                 
Val Ala Ala Lys Leu Phe Asp Glu Glu Gly Arg Lys Lys Phe Phe Thr
465                 470                 475                 480 
Gln Asp Met Asn Asn Ile Leu Leu Asp Ile Glu Leu Gln Leu Gln Glu
                485                 490                 495     
Leu Gly Pro Val Ile Arg Ser Gly Val Tyr Ser His Leu Glu Ala Phe
            500                 505                 510         
Val Pro Cys Asn Lys Glu Thr Leu Val Lys Arg Leu Lys Lys Leu His
        515                 520                 525             
Leu Asn Val Gln Asp Asp Arg Leu Arg Glu Pro Leu Gln Lys Leu Lys
    530                 535                 540                 
Leu Ala Val Ser Asn Val Met Pro Glu Gln Leu Phe Lys Tyr Gln Glu
545                 550                 555                 560 
Asp Cys Gln Ala Arg Ser Gln Ala Lys Cys Ala Lys Leu Gln Thr Asp
                565                 570                 575     
Glu Glu Arg Glu Lys Asn Gly Ser Glu Glu Asp Asp Asp Glu Lys Pro
            580                 585                 590         
Gly Lys Arg Val Ile Gly Pro Arg Lys Lys Phe His Trp Asp Asp Thr
        595                 600                 605             
Ile Arg Thr Leu Leu Cys Asn Leu Val Glu Ile Lys Leu Gly Cys Tyr
    610                 615                 620                 
Glu Leu Glu Pro Asn Lys Ser Gln Ser Ala Glu Asp Tyr Leu Lys Ser
625                 630                 635                 640 
Phe Met Glu Thr Glu Val Lys Pro Leu Trp Pro Lys Gly Trp Met Gln
                645                 650                 655     
Ala Arg Met Leu Phe Lys Glu Ser Arg Ser Val His Asn His Leu Thr
            660                 665                 670         
Ser Ala Pro Ala Lys Lys Lys Val Ile Pro Ala Pro Lys Pro Lys Val
        675                 680                 685             
Lys Glu Val Met Val Lys Thr Leu Pro Leu His Ser Phe Pro Thr Met
    690                 695                 700                 
Leu Lys Glu Cys Ser Pro Lys Lys Asp Gln Lys Thr Pro Thr Ser Leu
705                 710                 715                 720 
Val Ala Ser Val Ser Gly Pro Pro Thr Ser Ser Ser Thr Ala Ala Ile
                725                 730                 735     
Ala Ala Ala Ser Ser Ser Ser Ala Pro Ala Gln Glu Thr Ile Cys Leu
            740                 745                 750         
Asp Asp Ser Leu Asp Glu Asp Leu Ser Phe His Ser Pro Ser Leu Asp
        755                 760                 765             
Leu Val Ser Glu Ala Leu Ala Val Ile Asn Asn Gly Asn Lys Gly Pro
    770                 775                 780                 
Pro Val Gly Ser Arg Ile Ser Met Pro Thr Thr Lys Pro Arg Pro Gly
785                 790                 795                 800 
Leu Arg Glu Glu Lys Leu Ala Ser Ile Met Ser Lys Leu Pro Leu Ala
                805                 810                 815     
Thr Pro Lys Lys Leu Asp Ser Thr Gln Thr Thr His Ser Ser Ser Leu
            820                 825                 830         
Ile Ala Gly His Thr Gly Pro Val Pro Lys Lys Pro Gln Asp Leu Ala
        835                 840                 845             
His Thr Gly Ile Ser Ser Gly Leu Ile Ala Gly Ser Ser Ile Gln Asn
    850                 855                 860                 
Pro Lys Val Ser Leu Glu Pro Leu Pro Ala Arg Leu Leu Gln Gln Gly
865                 870                 875                 880 
Leu Gln Arg Ser Ser Gln Ile His Thr Ser Ser Ser Ser Gln Thr His
                885                 890                 895     
Val Ser Ser Ser Ser Gln Ala Gln Ile Ala Ala Ser Ser His Ala Leu
            900                 905                 910         
Gly Thr Ser Glu Ala Gln Asp Ala Ser Ser Leu Thr Gln Val Thr Lys
        915                 920                 925             
Val His Gln His Ser Ala Val Gln Gln Asn Tyr Val Ser Pro Leu Gln
    930                 935                 940                 
Ala Thr Ile Ser Lys Ser Gln Thr Asn Pro Val Val Lys Leu Ser Asn
945                 950                 955                 960 
Asn Pro Gln Leu Ser Cys Ser Ser Ser Leu Ile Lys Thr Ser Asp Lys
                965                 970                 975     
Pro Leu Met Tyr Arg Leu Pro Leu Ser Thr Pro Ser Pro Gly Asn Gly
            980                 985                 990         
Ser Gln Gly Ser His Pro Leu Val Ser Arg Thr Val Pro Ser Thr Thr
        995                 1000                1005            
Thr Ser Ser Asn Tyr Leu Ala Lys Ala Met Val Ser Gln Ile Ser Thr
    1010                1015                1020                
Gln Gly Phe Lys Ser Pro Phe Ser Met Ala Ala Ser Pro Lys Leu Ala
1025                1030                1035                1040
Ala Ser Pro Lys Pro Ala Thr Ser Pro Lys Pro Leu Pro Ser Pro Lys
                1045                1050                1055    
Pro Ser Ala Ser Pro Lys Pro Ser Leu Ser Ala Lys Pro Ser Val Ser
            1060                1065                1070        
Thr Lys Leu Ile Ser Lys Ser Asn Pro Thr Pro Lys Pro Thr Val Ser
        1075                1080                1085            
Pro Ser Ser Ser Ser Pro Asn Ala Leu Val Ala Gln Gly Ser His Ser
    1090                1095                1100                
Ser Thr Asn Ser Pro Val His Lys Gln Pro Ser Gly Met Asn Ile Ser
1105                1110                1115                1120
Arg Gln Ser Pro Thr Leu Asn Leu Leu Pro Ser Ser Arg Thr Ser Gly
                1125                1130                1135    
Leu Pro Pro Thr Lys Asn Leu Gln Ala Pro Ser Lys Leu Thr Asn Ser
            1140                1145                1150        
Ser Ser Thr Gly Thr Val Gly Lys Asn Ser Leu Ser Gly Ile Ala Met
        1155                1160                1165            
Asn Val Pro Ala Ser Arg Gly Ser Asn Leu Asn Ser Ser Gly Ala Asn
    1170                1175                1180                
Arg Thr Ser Leu Ser Gly Gly Thr Gly Ser Gly Thr Gln Gly Ala Thr
1185                1190                1195                1200
Lys Pro Leu Ser Thr Pro His Arg Pro Ser Thr Ala Ser Gly Ser Ser
                1205                1210                1215    
Val Val Thr Ala Ser Val Gln Ser Thr Ala Gly Ala Ser Leu Leu Ala
            1220                1225                1230        
Asn Ala Ser Pro Leu Thr Leu Met Thr Ser Pro Leu Ser Val Thr Asn
        1235                1240                1245            
Gln Asn Val Thr Pro Phe Gly Met Leu Gly Gly Leu Val Pro Val Thr
    1250                1255                1260                
Met Pro Phe Gln Phe Pro Leu Glu Ile Phe Gly Phe Gly Thr Asp Thr
1265                1270                1275                1280
Ala Gly Val Thr Thr Thr Ser Gly Ser Thr Ser Ala Ala Phe His His
                1285                1290                1295    
Ser Leu Thr Gln Asn Leu Leu Lys Gly Leu Gln Pro Gly Gly Ala Gln
            1300                1305                1310        
His Ala Ala Thr Leu Ser His Ser Pro Leu Pro Ala His Leu Gln Gln
        1315                1320                1325            
Ala Phe His Asp Gly Gly Gln Ser Lys Gly Asp Thr Lys Leu Pro Arg
    1330                1335                1340                
Lys Ser Gln
1345        


<210> 8098
<211> 326
<212> PRT
<213> Homo sapiens

<400> 8098
Met Glu Phe Leu Ser Glu Lys Phe Ala Leu Lys Ser Pro Pro Ser Lys
 1               5                  10                  15      
Asn Ser Asp Phe Tyr Met Gly Ala Gly Gly Pro Leu Glu His Val Met
            20                  25                  30          
Glu Thr Leu Asp Asn Glu Ser Phe Tyr Ser Lys Ala Ser Ala Gly Lys
        35                  40                  45              
Cys Val Gln Ala Phe Gly Pro Leu Pro Arg Ala Glu His His Val Arg
    50                  55                  60                  
Leu Glu Arg Thr Ser Pro Cys Gln Asp Ser Ser Val Asn Tyr Gly Ile
65                  70                  75                  80  
Thr Lys Val Glu Gly Gln Pro Leu His Thr Glu Leu Asn Arg Ala Met
                85                  90                  95      
Asp Asn Cys Asn Ser Leu Arg Met Ser Pro Val Lys Gly Met Gln Glu
            100                 105                 110         
Lys Gly Glu Leu Asp Glu Leu Gly Asp Lys Cys Asp Thr Asn Val Ser
        115                 120                 125             
Ser Ser Lys Lys Arg Arg His Arg Thr Thr Phe Thr Ser Leu Gln Leu
    130                 135                 140                 
Glu Glu Leu Glu Lys Val Phe Gln Lys Thr His Tyr Pro Asp Val Tyr
145                 150                 155                 160 
Val Arg Glu Gln Leu Ala Leu Arg Thr Glu Leu Thr Glu Ala Arg Val
                165                 170                 175     
Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg Glu Arg
            180                 185                 190         
Tyr Gly Gln Ile Gln Gln Ala Lys Ser His Phe Ala Ala Thr Tyr Asp
        195                 200                 205             
Ile Ser Val Leu Pro Arg Thr Asp Ser Tyr Pro Gln Ile Gln Asn Asn
    210                 215                 220                 
Leu Trp Ala Gly Asn Ala Ser Gly Gly Ser Val Val Thr Ser Cys Met
225                 230                 235                 240 
Leu Pro Arg Asp Thr Ser Ser Cys Met Thr Pro Tyr Ser His Ser Pro
                245                 250                 255     
Arg Thr Asp Ser Ser Tyr Thr Gly Phe Ser Asn His Gln Asn Gln Phe
            260                 265                 270         
Ser His Val Pro Leu Asn Asn Phe Phe Thr Asp Ser Leu Leu Thr Gly
        275                 280                 285             
Ala Thr Asn Gly His Ala Phe Glu Thr Lys Pro Glu Phe Glu Arg Arg
    290                 295                 300                 
Ser Ser Ser Ile Ala Val Leu Arg Met Lys Ala Lys Glu His Thr Ala
305                 310                 315                 320 
Asn Ile Ser Trp Ala Met
                325     


<210> 8099
<211> 341
<212> PRT
<213> Homo sapiens

<400> 8099
Met His Ser Lys Ser Gln Gly Ser Pro Gly Ser Cys Ser Gln Leu Cys
 1               5                  10                  15      
Gly Asp Ser Gly Thr Asp Ala Gly Ala Asp His Pro Leu Val Glu Ile
            20                  25                  30          
Val Leu Asp Ala Asp Asn Gln Gln Gly Pro Gly Tyr Ile Asp Ile Pro
        35                  40                  45              
Lys Gly Lys Gly Lys Gln Phe Asp Ala Gln Gly His Cys Leu Pro Asp
    50                  55                  60                  
Gly Arg Thr Glu Asn Thr Pro Gly Val Glu Thr Lys Gly Leu Asn Leu
65                  70                  75                  80  
Lys Ile Pro Arg Val Ile Ala Leu Glu Asn Pro Arg Thr Arg Ser Leu
                85                  90                  95      
His Arg Ala Leu Glu Glu Thr Pro Lys Gly Met Pro Lys Asp Leu Asn
            100                 105                 110         
Val Gly Gln Gln Ala Leu Ser Asn Ser Gly Ile Ser Glu Val Glu Gly
        115                 120                 125             
Leu Ser Gln His Gln Val Pro Glu Leu Ser Cys Thr Ser Ala Ala Asp
    130                 135                 140                 
Ala Ile Asn Arg Asn Ser Thr Gly Gln Gln Ser Gln Ser Gly Ser Pro
145                 150                 155                 160 
Cys Ile Met Asp Asp Thr Ala Phe Asn Arg Gly Val Asn Ala Phe Pro
                165                 170                 175     
Glu Ala Lys His Lys Ala Gly Thr Val Cys Pro Thr Val Thr His Ser
            180                 185                 190         
Val His Ser Gln Val Leu Lys Asn Gln Glu Leu Lys Ala Gly Thr Ser
        195                 200                 205             
Ile Met Gly Ser His Leu Thr Ser Ala Glu Thr Val Thr Leu Asp Ser
    210                 215                 220                 
Leu Lys Ala Val Glu Val Val Asn Leu Ser Val Ser Cys Thr Ala Thr
225                 230                 235                 240 
Cys Leu Pro Phe Ser Ser Val Pro Lys Glu Thr Pro Ala Arg Ala Gly
                245                 250                 255     
Phe Ser Ser Lys Gln Thr Leu Phe Pro Ile Thr His Gln Pro Leu Gly
            260                 265                 270         
Ser Phe Gly Val Val Ser Thr His Ser Ser Thr Leu Asp Glu Glu Val
        275                 280                 285             
Ser Glu Arg Met Phe Arg Gly Arg Gly Arg Lys Phe Gly Arg Trp Asn
    290                 295                 300                 
Ser Pro Gly Cys Leu Cys Pro Trp Pro Gly Trp Glu Gln Cys Arg Pro
305                 310                 315                 320 
Pro Ala Gly Lys Asp Phe His Arg Thr Gly Ala Pro Trp Arg Lys Thr
                325                 330                 335     
Gly Leu Pro Asn Val
            340     


<210> 8100
<211> 517
<212> PRT
<213> Homo sapiens

<400> 8100
Met Glu Asp Ser Ala Ser Ala Ser Leu Ser Ser Ala Ala Ala Thr Gly
 1               5                  10                  15      
Thr Ser Thr Ser Thr Pro Ala Ala Pro Thr Ala Arg Lys Gln Leu Asp
            20                  25                  30          
Lys Glu Gln Val Arg Lys Ala Val Asp Ala Leu Leu Thr His Cys Lys
        35                  40                  45              
Ser Arg Lys Asn Asn Tyr Gly Leu Leu Leu Asn Glu Asn Glu Ser Leu
    50                  55                  60                  
Phe Leu Met Val Val Leu Trp Lys Ile Pro Ser Lys Glu Leu Arg Val
65                  70                  75                  80  
Arg Leu Thr Leu Pro His Ser Ile Arg Ser Asp Ser Glu Asp Ile Cys
                85                  90                  95      
Leu Phe Thr Lys Asp Glu Pro Asn Ser Thr Pro Glu Lys Thr Glu Gln
            100                 105                 110         
Phe Tyr Arg Lys Leu Leu Asn Lys His Gly Ile Lys Thr Val Ser Gln
        115                 120                 125             
Ile Ile Ser Leu Gln Thr Leu Lys Lys Glu Tyr Lys Ser Tyr Glu Ala
    130                 135                 140                 
Lys Leu Arg Leu Leu Ser Ser Phe Asp Phe Phe Leu Thr Asp Ala Arg
145                 150                 155                 160 
Ile Arg Arg Leu Leu Pro Ser Leu Ile Gly Arg His Phe Tyr Gln Arg
                165                 170                 175     
Lys Lys Val Pro Val Ser Val Asn Leu Leu Ser Lys Asn Leu Ser Arg
            180                 185                 190         
Glu Ile Asn Asp Cys Ile Gly Gly Thr Val Leu Asn Ile Ser Lys Ser
        195                 200                 205             
Gly Ser Cys Ser Ala Ile Arg Ile Gly His Val Gly Met Gln Ile Glu
    210                 215                 220                 
His Ile Ile Glu Asn Ile Val Ala Val Thr Lys Gly Leu Ser Glu Lys
225                 230                 235                 240 
Leu Pro Glu Lys Trp Glu Ser Val Lys Leu Leu Phe Val Lys Thr Glu
                245                 250                 255     
Lys Ser Ala Ala Leu Pro Ile Phe Ser Ser Phe Val Ser Asn Trp Asp
            260                 265                 270         
Glu Ala Thr Lys Arg Ser Leu Leu Asn Lys Lys Lys Lys Glu Ala Arg
        275                 280                 285             
Arg Lys Arg Arg Glu Arg Asn Phe Glu Lys Gln Lys Glu Arg Lys Lys
    290                 295                 300                 
Lys Arg Gln Gln Ala Arg Lys Thr Ala Ser Val Leu Ser Lys Asp Asp
305                 310                 315                 320 
Val Ala Pro Glu Ser Gly Asp Thr Thr Val Lys Lys Pro Glu Ser Lys
                325                 330                 335     
Lys Glu Gln Thr Pro Glu His Gly Lys Lys Lys Arg Gly Arg Gly Lys
            340                 345                 350         
Ala Gln Val Lys Ala Thr Asn Glu Ser Glu Asp Glu Ile Pro Gln Leu
        355                 360                 365             
Val Pro Ile Gly Lys Lys Thr Pro Ala Asn Glu Lys Val Glu Ile Gln
    370                 375                 380                 
Lys His Ala Thr Gly Lys Lys Ser Pro Ala Lys Ser Pro Asn Pro Ser
385                 390                 395                 400 
Thr Pro Arg Gly Lys Lys Arg Lys Ala Leu Pro Ala Ser Glu Thr Pro
                405                 410                 415     
Lys Ala Ala Glu Ser Glu Thr Pro Gly Lys Ser Pro Glu Lys Lys Pro
            420                 425                 430         
Lys Ile Lys Glu Glu Ala Val Lys Glu Lys Ser Pro Ser Leu Gly Lys
        435                 440                 445             
Lys Asp Ala Arg Gln Thr Pro Lys Lys Pro Glu Ala Lys Phe Phe Thr
    450                 455                 460                 
Thr Pro Ser Lys Ser Val Arg Lys Ala Ser His Thr Pro Lys Lys Trp
465                 470                 475                 480 
Pro Lys Lys Pro Lys Tyr Pro Ser Arg Pro Lys Val Ser Asp Ser Thr
                485                 490                 495     
Gly Arg Lys Pro Gln Cys Cys Leu Gln Ser Phe Leu Glu Ile Leu Arg
            500                 505                 510         
Ser Trp Pro Pro Leu
        515         


<210> 8101
<211> 202
<212> PRT
<213> Homo sapiens

<400> 8101
Gly Gly Thr Arg Ser Gln Gln Trp Gly Cys Thr Arg Ala Ser Ser Arg
 1               5                  10                  15      
Gly Gly Asn Lys Met Glu Asp Ser Ala Ser Ala Ser Leu Ser Ser Ala
            20                  25                  30          
Ala Ala Thr Gly Thr Ser Thr Ser Thr Pro Ala Ala Pro Thr Ala Arg
        35                  40                  45              
Lys Gln Leu Asp Lys Glu Gln Val Arg Lys Ala Val Asp Ala Leu Leu
    50                  55                  60                  
Thr His Cys Lys Ser Arg Lys Asn Asn Tyr Gly Leu Leu Leu Asn Glu
65                  70                  75                  80  
Asn Glu Ser Leu Phe Leu Met Val Val Leu Trp Lys Ile Pro Ser Lys
                85                  90                  95      
Glu Leu Arg Val Arg Leu Thr Leu Pro His Ser Ile Arg Ser Asp Ser
            100                 105                 110         
Glu Asp Ile Cys Leu Phe Thr Lys Asp Glu Pro Asn Ser Thr Pro Glu
        115                 120                 125             
Lys Thr Glu Gln Phe Tyr Arg Lys Leu Leu Asn Lys His Gly Ile Lys
    130                 135                 140                 
Thr Val Ser Gln Ile Ile Ser Leu Gln Thr Leu Lys Lys Glu Tyr Lys
145                 150                 155                 160 
Ser Tyr Glu Ala Lys Leu Arg Leu Leu Ser Ser Phe Asp Phe Phe Leu
                165                 170                 175     
Thr Asp Ala Arg Ile Arg Arg Leu Leu Pro Ser Leu Ile Gly Arg His
            180                 185                 190         
Phe Tyr Gln Arg Lys Lys Phe Gln Tyr Leu
        195                 200         


<210> 8102
<211> 1709
<212> PRT
<213> Homo sapiens

<400> 8102
Met Lys Lys Ile Phe Ser Lys Lys Gly Glu Ser Pro Leu Gly Ser Phe
 1               5                  10                  15      
Ala Arg Arg Arg Arg Ser Ser Ala Gly Gly Gly Gly Glu Pro Gly Glu
            20                  25                  30          
Gly Ala Tyr Ser Gln Pro Gly Tyr His Val Arg Asp Arg Asp Leu Gly
        35                  40                  45              
Lys Ile His Lys Ala Ala Ser Ala Gly Asn Val Ala Lys Val Gln Gln
    50                  55                  60                  
Ile Leu Leu Leu Arg Lys Asn Gly Leu Asn Asp Arg Asp Lys Met Asn
65                  70                  75                  80  
Arg Thr Ala Leu His Leu Ala Cys Ala Asn Gly His Pro Glu Val Val
                85                  90                  95      
Thr Leu Leu Val Asp Arg Lys Cys Gln Leu Asn Val Cys Asp Asn Glu
            100                 105                 110         
Asn Arg Thr Ala Leu Met Lys Ala Val Gln Cys Gln Glu Glu Lys Cys
        115                 120                 125             
Ala Thr Ile Leu Leu Glu His Gly Ala Asp Pro Asn Leu Ala Asp Val
    130                 135                 140                 
His Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Ile Ser
145                 150                 155                 160 
Val Ala Thr Lys Leu Leu Leu Tyr Asp Ala Asn Ile Glu Ala Lys Asn
                165                 170                 175     
Lys Asp Asp Leu Thr Pro Leu Leu Leu Ala Val Ser Gly Lys Lys Gln
            180                 185                 190         
Gln Met Val Glu Phe Leu Ile Lys Lys Lys Ala Asn Val Asn Ala Val
        195                 200                 205             
Asp Lys Leu Glu Ser Ser His Gln Leu Ile Ser Glu Tyr Lys Glu Glu
    210                 215                 220                 
Arg Ile Pro Lys His Ser Ser Gln Asn Ser Asn Ser Val Asp Glu Ser
225                 230                 235                 240 
Ser Glu Asp Ser Leu Ser Arg Leu Ser Gly Lys Pro Gly Val Asp Asp
                245                 250                 255     
Ser Trp Pro Thr Ser Asp Asp Glu Asp Leu Asn Phe Asp Thr Lys Asn
            260                 265                 270         
Val Pro Lys Pro Ser Leu Ala Lys Leu Met Thr Ala Ser Gln Gln Ser
        275                 280                 285             
Arg Lys Asn Leu Glu Ala Thr Tyr Gly Thr Val Arg Thr Gly Asn Arg
    290                 295                 300                 
Thr Leu Phe Glu Asp Arg Asp Ser Asp Ser Gln Asp Glu Val Val Val
305                 310                 315                 320 
Glu Ser Leu Pro Thr Thr Ser Ile Lys Val Gln Cys Phe Ser His Pro
                325                 330                 335     
Thr Tyr Gln Ser Pro Asp Leu Leu Pro Lys Pro Ser His Lys Ser Leu
            340                 345                 350         
Ala Asn Pro Gly Leu Met Lys Glu Glu Pro Thr Lys Pro Gly Ile Ala
        355                 360                 365             
Lys Lys Glu Asn Gly Ile Asp Ile Ile Glu Ser Ala Pro Leu Glu Gln
    370                 375                 380                 
Thr Asn Asn Asp Asn Leu Thr Tyr Val Asp Glu Val His Lys Asn Asn
385                 390                 395                 400 
Arg Ser Asp Met Met Ser Ala Leu Gly Leu Gly Gln Glu Glu Asp Ile
                405                 410                 415     
Glu Ser Pro Trp Asp Ser Glu Ser Ile Ser Glu Asn Phe Pro Gln Lys
            420                 425                 430         
Tyr Val Asp Pro Leu Ala Gly Ala Ala Asp Gly Lys Glu Lys Asn Ile
        435                 440                 445             
Gly Asn Glu Gln Ala Glu Asp Val Phe Tyr Ile Pro Ser Cys Met Ser
    450                 455                 460                 
Gly Ser Arg Asn Phe Lys Met Ala Lys Leu Glu Asp Thr Arg Asn Val
465                 470                 475                 480 
Gly Met Pro Val Ala His Met Glu Ser Pro Glu Arg Tyr Leu His Leu
                485                 490                 495     
Lys Pro Thr Ile Glu Met Lys Asp Ser Val Pro Asn Lys Ala Gly Gly
            500                 505                 510         
Met Lys Asp Val Gln Thr Ser Lys Ala Ala Glu His Asp Leu Glu Val
        515                 520                 525             
Ala Ser Glu Glu Glu Gln Glu Arg Glu Gly Ser Glu Asn Asn Gln Pro
    530                 535                 540                 
Gln Val Glu Glu Glu Arg Lys Lys His Arg Asn Asn Glu Met Glu Val
545                 550                 555                 560 
Ser Ala Asn Ile His Asp Gly Ala Thr Asp Asp Ala Glu Asp Asp Asp
                565                 570                 575     
Asp Asp Asp Gly Leu Ile Gln Lys Arg Lys Ser Gly Glu Thr Asp His
            580                 585                 590         
Gln Gln Phe Pro Arg Lys Glu Asn Lys Glu Tyr Ala Ser Gly Pro Ala
        595                 600                 605             
Leu Gln Met Lys Glu Val Lys Ser Thr Glu Lys Glu Lys Arg Thr Ser
    610                 615                 620                 
Lys Glu Ser Val Asn Ser Pro Val Phe Gly Lys Ala Ser Leu Leu Thr
625                 630                 635                 640 
Gly Gly Leu Leu Gln Val Asp Asp Asp Ser Ser Leu Ser Glu Ile Asp
                645                 650                 655     
Glu Asp Glu Gly Arg Pro Thr Lys Lys Thr Ser Asn Glu Lys Asn Lys
            660                 665                 670         
Val Lys Asn Gln Ile Gln Ser Met Asp Asp Val Asp Asp Leu Thr Gln
        675                 680                 685             
Ser Ser Glu Thr Ala Ser Glu Asp Cys Glu Leu Pro His Ser Ser Tyr
    690                 695                 700                 
Lys Asn Phe Met Leu Leu Ile Glu Gln Leu Gly Met Glu Cys Lys Asp
705                 710                 715                 720 
Ser Val Ser Leu Leu Lys Ile Gln Asp Ala Ala Leu Ser Cys Glu Arg
                725                 730                 735     
Leu Leu Glu Leu Lys Lys Asn His Cys Glu Leu Leu Thr Val Lys Ile
            740                 745                 750         
Lys Lys Met Glu Asp Lys Val Asn Val Leu Gln Arg Glu Leu Ser Glu
        755                 760                 765             
Thr Lys Glu Ile Lys Ser Gln Leu Glu His Gln Lys Val Glu Trp Glu
    770                 775                 780                 
Arg Glu Leu Cys Ser Leu Arg Phe Ser Leu Asn Gln Glu Glu Glu Lys
785                 790                 795                 800 
Arg Arg Asn Ala Asp Thr Leu Tyr Glu Lys Ile Arg Glu Gln Leu Arg
                805                 810                 815     
Arg Lys Glu Glu Gln Tyr Arg Lys Glu Val Glu Val Lys Gln Gln Leu
            820                 825                 830         
Glu Leu Ser Leu Gln Thr Leu Glu Met Glu Leu Arg Thr Val Lys Ser
        835                 840                 845             
Asn Leu Asn Gln Val Val Gln Glu Arg Asn Asp Ala Gln Arg Gln Leu
    850                 855                 860                 
Ser Arg Glu Gln Asn Ala Arg Met Leu Gln Asp Gly Ile Leu Thr Asn
865                 870                 875                 880 
His Leu Ser Lys Gln Lys Glu Ile Glu Met Ala Gln Lys Lys Met Asn
                885                 890                 895     
Ser Glu Asn Ser His Ser His Glu Glu Glu Lys Asp Leu Ser His Lys
            900                 905                 910         
Asn Ser Met Leu Gln Glu Glu Ile Ala Met Leu Arg Leu Glu Ile Asp
        915                 920                 925             
Thr Ile Lys Asn Gln Asn Gln Glu Lys Glu Lys Lys Cys Phe Glu Asp
    930                 935                 940                 
Leu Lys Ile Val Lys Glu Lys Asn Glu Asp Leu Gln Lys Thr Ile Lys
945                 950                 955                 960 
Gln Asn Glu Glu Thr Leu Thr Gln Thr Ile Ser Gln Tyr Asn Gly Arg
                965                 970                 975     
Leu Ser Val Leu Thr Ala Glu Asn Ala Met Leu Asn Ser Lys Leu Glu
            980                 985                 990         
Asn Glu Lys Gln Ser Lys Glu Arg Leu Glu Ala Glu Val Glu Ser Tyr
        995                 1000                1005            
His Ser Arg Leu Ala Ala Ala Ile His Asp Arg Asp Gln Ser Glu Thr
    1010                1015                1020                
Ser Lys Arg Glu Leu Glu Leu Ala Phe Gln Arg Ala Arg Asp Glu Cys
1025                1030                1035                1040
Ser Arg Leu Gln Asp Lys Met Asn Phe Asp Val Ser Asn Leu Lys Asp
                1045                1050                1055    
Asn Asn Glu Ile Leu Ser Gln Gln Leu Phe Lys Thr Glu Ser Lys Leu
            1060                1065                1070        
Asn Ser Leu Glu Ile Glu Phe His His Thr Arg Asp Ala Leu Arg Glu
        1075                1080                1085            
Lys Thr Leu Gly Leu Glu Arg Val Gln Lys Asp Leu Ser Gln Thr Gln
    1090                1095                1100                
Cys Gln Met Lys Glu Met Glu Gln Lys Tyr Gln Asn Glu Gln Val Lys
1105                1110                1115                1120
Val Asn Lys Tyr Ile Gly Lys Gln Glu Ser Val Glu Glu Arg Leu Ser
                1125                1130                1135    
Gln Leu Gln Ser Glu Asn Met Leu Leu Arg Gln Gln Leu Asp Asp Ala
            1140                1145                1150        
His Asn Lys Ala Asp Asn Lys Glu Lys Thr Val Ile Asn Ile Gln Asp
        1155                1160                1165            
Gln Phe His Ala Ile Val Gln Lys Leu Gln Ala Glu Ser Glu Lys Gln
    1170                1175                1180                
Ser Leu Leu Leu Glu Glu Arg Asn Lys Glu Leu Ile Ser Glu Cys Asn
1185                1190                1195                1200
His Leu Lys Glu Arg Gln Tyr Gln Tyr Glu Asn Glu Lys Ala Glu Arg
                1205                1210                1215    
Glu Val Val Val Arg Gln Leu Gln Gln Glu Leu Ala Asp Thr Leu Lys
            1220                1225                1230        
Lys Gln Ser Met Ser Glu Ala Ser Leu Glu Val Thr Ser Arg Tyr Arg
        1235                1240                1245            
Ile Asn Leu Glu Asp Glu Thr Gln Asp Leu Lys Lys Lys Leu Gly Gln
    1250                1255                1260                
Ile Arg Asn Gln Leu Gln Glu Ala Gln Asp Arg His Thr Glu Ala Val
1265                1270                1275                1280
Arg Cys Ala Glu Lys Met Gln Asp His Lys Gln Lys Leu Glu Lys Asp
                1285                1290                1295    
Asn Ala Lys Leu Lys Val Thr Val Lys Lys Gln Met Asp Lys Ile Glu
            1300                1305                1310        
Glu Leu Gln Lys Asn Leu Leu Asn Ala Asn Leu Ser Glu Asp Glu Lys
        1315                1320                1325            
Glu Gln Leu Lys Lys Leu Met Glu Leu Lys Gln Ser Leu Glu Cys Asn
    1330                1335                1340                
Leu Asp Gln Glu Met Lys Lys Asn Val Glu Leu Glu Arg Glu Ile Thr
1345                1350                1355                1360
Gly Phe Lys Asn Leu Leu Lys Met Thr Arg Lys Lys Leu Asn Glu Tyr
                1365                1370                1375    
Glu Asn Gly Glu Phe Ser Phe His Gly Asp Leu Lys Thr Ser Gln Phe
            1380                1385                1390        
Glu Met Asp Ile Gln Ile Asn Lys Leu Lys His Lys Ile Asp Asp Leu
        1395                1400                1405            
Thr Ala Glu Leu Glu Thr Ala Gly Ser Lys Cys Leu His Leu Asp Thr
    1410                1415                1420                
Lys Asn Gln Ile Leu Gln Glu Glu Leu Leu Ser Met Lys Thr Val Gln
1425                1430                1435                1440
Lys Lys Cys Glu Lys Leu Gln Lys Asn Lys Lys Lys Leu Glu Gln Glu
                1445                1450                1455    
Val Ile Asn Leu Arg Ser His Ile Glu Arg Asn Met Val Glu Leu Gly
            1460                1465                1470        
Gln Val Lys Gln Tyr Lys Gln Glu Ile Glu Glu Arg Ala Arg Gln Glu
        1475                1480                1485            
Ile Ala Glu Lys Leu Lys Glu Val Asn Leu Phe Leu Gln Ala Gln Ala
    1490                1495                1500                
Ala Ser Gln Glu Asn Leu Glu Gln Phe Arg Glu Asn Asn Phe Ala Ser
1505                1510                1515                1520
Met Lys Ser Gln Met Glu Leu Arg Ile Lys Asp Leu Glu Ser Glu Leu
                1525                1530                1535    
Ser Lys Ile Lys Thr Ser Gln Glu Asp Phe Asn Lys Thr Glu Leu Glu
            1540                1545                1550        
Lys Tyr Lys Gln Leu Tyr Leu Glu Glu Leu Lys Val Arg Lys Ser Leu
        1555                1560                1565            
Ser Ser Lys Leu Thr Lys Thr Asn Glu Arg Leu Ala Glu Val Asn Thr
    1570                1575                1580                
Lys Leu Leu Val Glu Lys Gln Gln Ser Arg Ser Leu Phe Thr Thr Leu
1585                1590                1595                1600
Thr Thr Arg Pro Val Met Glu Pro Pro Cys Val Gly Asn Leu Asn Asn
                1605                1610                1615    
Ser Leu Asp Leu Asn Arg Lys Leu Ile Pro Arg Glu Asn Leu Val Ile
            1620                1625                1630        
Ser Thr Ser Asn Pro Arg Ala Ser Asn Asn Ser Met Glu Asn Tyr Leu
        1635                1640                1645            
Ser Lys Met Gln Gln Glu Leu Glu Lys Asn Ile Thr Arg Glu Leu Lys
    1650                1655                1660                
Glu Ala Ala Ala Glu Leu Glu Ser Gly Ser Ile Ala Ser Pro Leu Gly
1665                1670                1675                1680
Ser Thr Asp Glu Ser Asn Leu Asn Gln Asp Leu Val Trp Lys Ala Ser
                1685                1690                1695    
Arg Glu Tyr Val Gln Val Leu Lys Lys Asn Tyr Met Ile
            1700                1705                


<210> 8103
<211> 1269
<212> PRT
<213> Homo sapiens

<400> 8103
Met Glu Ala Thr Gly Val Leu Pro Phe Val Arg Gly Val Asp Leu Ser
 1               5                  10                  15      
Gly Asn Asp Phe Lys Gly Gly Tyr Phe Pro Glu Asn Val Lys Ala Met
            20                  25                  30          
Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr Gly Leu Cys Tyr Leu
        35                  40                  45              
Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu His Leu Ser Val Ser
    50                  55                  60                  
His Asn Asn Leu Thr Thr Leu His Gly Glu Leu Ser Ser Leu Pro Ser
65                  70                  75                  80  
Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu Lys Asn Ser Gly Val
                85                  90                  95      
Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser Val Leu Asp Leu Ser
            100                 105                 110         
His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu Glu Asn Ala Lys Asn
        115                 120                 125             
Met Leu Val Leu Asn Leu Ser His Asn Ser Ile Asp Thr Ile Pro Asn
    130                 135                 140                 
Gln Leu Phe Ile Asn Leu Thr Asp Leu Leu Tyr Leu Asp Leu Ser Glu
145                 150                 155                 160 
Asn Arg Leu Glu Ser Leu Pro Pro Gln Met Arg Arg Leu Val His Leu
                165                 170                 175     
Gln Thr Leu Val Leu Asn Gly Asn Pro Leu Leu His Ala Gln Leu Arg
            180                 185                 190         
Gln Leu Pro Ala Met Thr Ala Leu Gln Thr Leu His Leu Arg Ser Thr
        195                 200                 205             
Gln Arg Thr Gln Ser Asn Leu Pro Thr Ser Leu Glu Gly Leu Ser Asn
    210                 215                 220                 
Leu Ala Asp Val Asp Leu Ser Cys Asn Asp Leu Thr Arg Val Pro Glu
225                 230                 235                 240 
Cys Leu Tyr Thr Leu Pro Ser Leu Arg Arg Leu Asn Leu Ser Ser Asn
                245                 250                 255     
Gln Ile Thr Glu Leu Ser Leu Cys Ile Asp Gln Trp Val His Val Glu
            260                 265                 270         
Thr Leu Asn Leu Ser Arg Asn Gln Leu Thr Ser Leu Pro Ser Ala Ile
        275                 280                 285             
Cys Lys Leu Ser Lys Leu Lys Lys Leu Tyr Leu Asn Ser Asn Lys Leu
    290                 295                 300                 
Asp Phe Asp Gly Leu Pro Ser Gly Ile Gly Lys Leu Thr Asn Leu Glu
305                 310                 315                 320 
Glu Phe Met Ala Ala Asn Asn Asn Leu Glu Leu Val Pro Glu Ser Leu
                325                 330                 335     
Cys Arg Cys Pro Lys Leu Arg Lys Leu Val Leu Asn Lys Asn His Leu
            340                 345                 350         
Val Thr Leu Pro Glu Ala Ile His Phe Leu Thr Glu Ile Glu Val Leu
        355                 360                 365             
Asp Val Arg Glu Asn Pro Asn Leu Val Met Pro Pro Lys Pro Ala Asp
    370                 375                 380                 
Arg Ala Ala Glu Trp Tyr Asn Ile Asp Phe Ser Leu Gln Asn Gln Leu
385                 390                 395                 400 
Arg Leu Ala Gly Ala Ser Pro Ala Thr Val Ala Ala Ala Ala Ala Ala
                405                 410                 415     
Gly Ser Gly Pro Lys Asp Pro Met Ala Arg Lys Met Arg Leu Arg Arg
            420                 425                 430         
Arg Lys Asp Ser Ala Gln Asp Asp Gln Ala Lys Gln Val Leu Lys Gly
        435                 440                 445             
Met Ser Asp Val Ala Gln Glu Lys Asn Lys Lys Gln Glu Glu Ser Ala
    450                 455                 460                 
Asp Ala Arg Ala Pro Ser Gly Lys Val Arg Arg Trp Asp Gln Gly Leu
465                 470                 475                 480 
Glu Lys Pro Arg Leu Asp Tyr Ser Glu Phe Phe Thr Glu Asp Val Gly
                485                 490                 495     
Gln Leu Pro Gly Leu Thr Ile Trp Gln Ile Glu Asn Phe Val Pro Val
            500                 505                 510         
Leu Val Glu Glu Ala Phe His Gly Lys Phe Tyr Glu Ala Asp Cys Tyr
        515                 520                 525             
Ile Val Leu Lys Thr Phe Leu Asp Asp Ser Gly Ser Leu Asn Trp Glu
    530                 535                 540                 
Ile Tyr Tyr Trp Ile Gly Gly Glu Ala Thr Leu Asp Lys Lys Ala Cys
545                 550                 555                 560 
Ser Ala Ile His Ala Val Asn Leu Arg Asn Tyr Leu Gly Ala Glu Cys
                565                 570                 575     
Arg Thr Val Arg Glu Glu Met Gly Asp Glu Ser Glu Glu Phe Leu Gln
            580                 585                 590         
Val Phe Asp Asn Asp Ile Ser Tyr Ile Glu Gly Gly Thr Ala Ser Gly
        595                 600                 605             
Phe Tyr Thr Val Glu Asp Thr His Tyr Val Thr Arg Met Tyr Arg Val
    610                 615                 620                 
Tyr Gly Lys Lys Asn Ile Lys Leu Glu Pro Val Pro Leu Lys Gly Thr
625                 630                 635                 640 
Ser Leu Asp Pro Arg Phe Val Phe Leu Leu Asp Arg Gly Leu Asp Ile
                645                 650                 655     
Tyr Val Trp Arg Gly Ala Gln Ala Thr Leu Ser Ser Thr Thr Lys Ala
            660                 665                 670         
Arg Leu Phe Ala Glu Lys Ile Asn Lys Asn Glu Arg Lys Gly Lys Ala
        675                 680                 685             
Glu Ile Thr Leu Leu Val Gln Gly Gln Glu Leu Pro Glu Phe Trp Glu
    690                 695                 700                 
Ala Leu Gly Gly Glu Pro Ser Glu Ile Lys Lys His Val Pro Glu Asp
705                 710                 715                 720 
Phe Trp Pro Pro Gln Pro Lys Leu Tyr Lys Val Gly Leu Gly Leu Gly
                725                 730                 735     
Tyr Leu Glu Leu Pro Gln Ile Asn Tyr Lys Leu Ser Val Glu His Lys
            740                 745                 750         
Gln Arg Pro Lys Val Glu Leu Met Pro Arg Met Arg Leu Leu Gln Ser
        755                 760                 765             
Leu Leu Asp Thr Arg Cys Val Tyr Ile Leu Asp Cys Trp Ser Asp Val
    770                 775                 780                 
Phe Ile Trp Leu Gly Arg Lys Ser Pro Arg Leu Val Arg Ala Ala Ala
785                 790                 795                 800 
Leu Lys Leu Gly Gln Glu Leu Cys Gly Met Leu His Arg Pro Arg His
                805                 810                 815     
Ala Thr Val Ser Arg Ser Leu Glu Gly Thr Glu Ala Gln Val Phe Lys
            820                 825                 830         
Ala Lys Phe Lys Asn Trp Asp Asp Val Leu Thr Val Asp Tyr Thr Arg
        835                 840                 845             
Asn Ala Glu Ala Val Leu Gln Ser Pro Gly Leu Ser Gly Lys Val Lys
    850                 855                 860                 
Arg Asp Ala Glu Lys Lys Asp Gln Met Lys Ala Asp Leu Thr Ala Leu
865                 870                 875                 880 
Phe Leu Pro Arg Gln Pro Pro Met Ser Leu Ala Glu Ala Glu Gln Leu
                885                 890                 895     
Met Glu Glu Trp Asn Glu Asp Leu Asp Gly Met Glu Gly Phe Val Leu
            900                 905                 910         
Glu Gly Lys Lys Phe Ala Arg Leu Pro Glu Glu Glu Phe Gly His Phe
        915                 920                 925             
Tyr Thr Gln Asp Cys Tyr Val Phe Leu Cys Arg Tyr Trp Val Pro Val
    930                 935                 940                 
Glu Tyr Glu Glu Glu Glu Lys Lys Glu Asp Lys Glu Glu Lys Ala Glu
945                 950                 955                 960 
Gly Lys Glu Gly Glu Glu Ala Thr Ala Glu Ala Glu Glu Lys Gln Pro
                965                 970                 975     
Glu Glu Asp Phe Gln Cys Ile Val Tyr Phe Trp Gln Gly Arg Glu Ala
            980                 985                 990         
Ser Asn Met Gly Trp Leu Thr Phe Thr Phe Ser Leu Gln Lys Lys Phe
        995                 1000                1005            
Glu Ser Leu Phe Pro Gly Lys Leu Glu Val Val Arg Met Thr Gln Gln
    1010                1015                1020                
Gln Glu Asn Pro Lys Phe Leu Ser His Phe Lys Arg Lys Phe Ile Ile
1025                1030                1035                1040
His Arg Gly Lys Arg Lys Ala Val Gln Gly Ala Gln Gln Pro Ser Leu
                1045                1050                1055    
Tyr Gln Ile Arg Thr Asn Gly Ser Ala Leu Cys Thr Arg Cys Ile Gln
            1060                1065                1070        
Ile Asn Thr Asp Ser Ser Leu Leu Asn Ser Glu Phe Cys Phe Ile Leu
        1075                1080                1085            
Lys Val Pro Phe Glu Ser Glu Asp Asn Gln Gly Ile Val Tyr Ala Trp
    1090                1095                1100                
Val Gly Arg Ala Ser Asp Pro Asp Glu Ala Lys Leu Ala Glu Asp Ile
1105                1110                1115                1120
Leu Asn Thr Met Phe Asp Thr Ser Tyr Ser Lys Gln Val Ile Asn Glu
                1125                1130                1135    
Gly Glu Glu Pro Glu Asn Phe Phe Trp Val Gly Ile Gly Ala Gln Lys
            1140                1145                1150        
Pro Tyr Asp Asp Asp Ala Glu Tyr Met Lys His Thr Arg Leu Phe Arg
        1155                1160                1165            
Cys Ser Asn Glu Lys Gly Tyr Phe Ala Val Thr Glu Lys Cys Ser Asp
    1170                1175                1180                
Phe Cys Gln Asp Asp Leu Ala Asp Asp Asp Ile Met Leu Leu Asp Asn
1185                1190                1195                1200
Gly Gln Glu Val Tyr Met Trp Val Gly Thr Gln Thr Ser Gln Val Glu
                1205                1210                1215    
Ile Lys Leu Ser Leu Lys Ala Cys Gln Val Tyr Ile Gln His Met Arg
            1220                1225                1230        
Ser Lys Glu His Glu Arg Pro Arg Arg Leu Arg Leu Val Arg Lys Gly
        1235                1240                1245            
Asn Glu Gln His Ala Phe Thr Arg Cys Phe His Ala Trp Ser Ala Phe
    1250                1255                1260                
Cys Lys Ala Leu Ala
1265                


<210> 8104
<211> 179
<212> PRT
<213> Homo sapiens

<400> 8104
Met Gly Met Val Gly Thr Gln Thr Trp Gln Lys Asn Met Ala Gln Glu
 1               5                  10                  15      
Thr Asn Gln Thr Pro Gly Pro Met Leu Cys Ser Thr Gly Cys Gly Phe
            20                  25                  30          
Tyr Gly Asn Pro Arg Thr Asn Gly Met Cys Ser Val Cys Tyr Lys Glu
        35                  40                  45              
His Leu Gln Arg Gln Gln Asn Ser Gly Arg Met Ser Pro Met Gly Thr
    50                  55                  60                  
Ala Ser Gly Ser Asn Ser Pro Thr Ser Asp Ser Ala Ser Val Gln Arg
65                  70                  75                  80  
Ala Asp Thr Ser Leu Asn Asn Cys Glu Gly Ala Ala Gly Ser Pro Ser
                85                  90                  95      
Val Phe Gln Pro Ser Thr Ser Gln Ser Lys Glu Lys Ala Pro Glu Leu
            100                 105                 110         
Pro Lys Pro Lys Lys Asn Arg Cys Phe Met Cys Arg Lys Lys Val Gly
        115                 120                 125             
Leu Thr Gly Leu Thr Ala Asp Val Glu Ile Cys Phe Val Asp Phe Thr
    130                 135                 140                 
Val Asn Ser Asp Lys His Asn Cys Pro Tyr Asp Tyr Lys Ala Glu Ala
145                 150                 155                 160 
Ala Ala Lys Ile Arg Lys Glu Asn Pro Val Val Val Ala Glu Lys Ile
                165                 170                 175     
Gln Arg Ile
            


<210> 8105
<211> 365
<212> PRT
<213> Homo sapiens

<400> 8105
Met His Ala Val Pro Arg Gly Phe Gly Lys Lys Val Arg Val Gly Val
 1               5                  10                  15      
Gln Ser Cys Pro Ser Pro Phe Ser Gly Gln Ala Cys Pro Gln Pro Ser
            20                  25                  30          
Ser Val Phe Trp Ser Leu Leu Lys Asn Leu Pro Phe Leu Glu His Leu
        35                  40                  45              
Glu Leu Ile Gly Ser Asn Phe Ser Ser Ala Met Pro Arg Asn Glu Pro
    50                  55                  60                  
Ala Ile Arg Asn Ser Leu Pro Pro Cys Ser Arg Ala Gln Ser Val Gly
65                  70                  75                  80  
Asp Ser Glu Val Ala Ala Ile Gly Gln Leu Ala Phe Leu Arg His Leu
                85                  90                  95      
Thr Leu Ala Gln Leu Pro Ser Val Leu Thr Gly Ser Gly Leu Val Asn
            100                 105                 110         
Ile Gly Pro Gln Cys Gln Gln Leu Arg Ser Leu Ser Leu Ala Asn Leu
        115                 120                 125             
Gly Met Met Gly Lys Val Val Tyr Met Pro Ala Leu Ser Asp Met Leu
    130                 135                 140                 
Lys His Cys Lys Arg Leu Arg Asp Leu Arg Leu Glu Gln Pro Tyr Phe
145                 150                 155                 160 
Ser Ala Asn Ala Gln Phe Phe Gln Ala Leu Ser Gln Cys Pro Ser Leu
                165                 170                 175     
Gln Arg Leu Cys Leu Val Ser Arg Ser Gly Thr Leu Gln Pro Asp Ala
            180                 185                 190         
Val Leu Ala Phe Met Ala Arg Cys Leu Gln Val Val Met Cys His Leu
        195                 200                 205             
Phe Thr Gly Glu Ser Leu Ala Thr Cys Lys Ser Leu Gln Gln Ser Leu
    210                 215                 220                 
Leu Arg Arg Trp Gly Glu Val Thr Gly Arg Arg Pro Gln Leu Phe Thr
225                 230                 235                 240 
Glu Leu Arg Glu Glu Pro Ser Ala Arg Thr Ser Arg Ala Thr Gly Arg
                245                 250                 255     
Arg Gln Pro Cys Leu Pro Asp Ser Gly Val Val Cys Cys Pro Cys Gly
            260                 265                 270         
Arg Pro Leu Ala Val Ser Gly Ile Ile Leu Val Gly Val Ser Pro Ser
        275                 280                 285             
Leu Val Val Lys Thr Thr Cys Val Tyr Arg Val Leu Phe Lys Asn Leu
    290                 295                 300                 
Asp Tyr Ala Ser Ile Phe Phe Leu Val Cys Leu Phe Glu Thr Glu Ser
305                 310                 315                 320 
His Ser Val Val Gln Ala Gly Val Gln Trp Arg Asp Leu Ser Ser Leu
                325                 330                 335     
Gln Pro Leu Leu Ser Gly Leu Gln Pro Gln Pro Pro Glu Gln Leu Glu
            340                 345                 350         
Asn Glu Leu Glu Ile Gly Phe Ser Tyr Cys Phe Val Ile
        355                 360                 365 


<210> 8106
<211> 243
<212> PRT
<213> Homo sapiens

<400> 8106
Trp Ser Leu Leu Lys Asn Leu Pro Phe Leu Glu His Leu Glu Leu Ile
 1               5                  10                  15      
Gly Ser Asn Phe Ser Ser Ala Met Pro Arg Asn Glu Pro Ala Ile Arg
            20                  25                  30          
Asn Ser Leu Pro Pro Cys Ser Arg Ala Gln Ser Val Gly Asp Ser Glu
        35                  40                  45              
Val Ala Ala Ile Gly Gln Leu Ala Phe Leu Arg His Leu Thr Leu Ala
    50                  55                  60                  
Gln Leu Pro Ser Val Leu Thr Gly Ser Gly Leu Val Asn Ile Gly Leu
65                  70                  75                  80  
Gln Cys Gln Gln Leu Arg Ser Leu Ser Leu Ala Asn Leu Gly Met Met
                85                  90                  95      
Gly Lys Val Val Tyr Met Pro Ala Leu Ser Asp Met Leu Lys His Cys
            100                 105                 110         
Lys Arg Leu Arg Asp Leu Arg Leu Glu Gln Pro Tyr Phe Ser Ala Asn
        115                 120                 125             
Ala Gln Phe Phe Gln Ala Leu Ser Gln Cys Pro Ser Leu Gln Arg Leu
    130                 135                 140                 
Cys Leu Val Ser Arg Ser Gly Thr Leu Gln Pro Asp Ala Val Leu Ala
145                 150                 155                 160 
Phe Met Ala Arg Cys Leu Gln Val Val Met Cys His Leu Phe Thr Gly
                165                 170                 175     
Glu Ser Leu Ala Thr Cys Lys Ser Leu Gln Gln Ser Leu Leu Arg Ser
            180                 185                 190         
Phe Gln Ala Glu Arg Pro Ala Leu Asn Val Val Ile Phe Pro Leu Leu
        195                 200                 205             
His Glu Gly Leu Thr Asp Val Ile Arg Asp Val Pro Leu Val His Leu
    210                 215                 220                 
Asp Glu Ile Thr Leu Phe Lys Ser Arg Val Ala Glu Glu Pro Pro Asn
225                 230                 235                 240 
Leu Trp Trp
            


<210> 8107
<211> 695
<212> PRT
<213> Homo sapiens

<400> 8107
Arg Leu Arg Ala Ser Leu Ala Gly Gln Val Gly Gly Thr Gly Leu Arg
 1               5                  10                  15      
Ile Pro Arg Pro Arg Phe Gly Pro Ala Gly Asp Met Ala Ser Ser Gly
            20                  25                  30          
Glu Asp Ile Ser Asn Asp Asp Asp Asp Met His Pro Ala Ala Ala Gly
        35                  40                  45              
Met Ala Asp Gly Val His Leu Leu Gly Phe Ser Asp Glu Ile Leu Leu
    50                  55                  60                  
His Ile Leu Ser His Val Pro Ser Thr Asp Leu Ile Leu Asn Val Arg
65                  70                  75                  80  
Arg Thr Cys Arg Lys Leu Ala Ala Leu Cys Leu Asp Lys Ser Leu Ile
                85                  90                  95      
His Thr Val Leu Leu Gln Lys Asp Tyr Gln Ala Ser Glu Asp Lys Val
            100                 105                 110         
Arg Gln Leu Val Lys Glu Ile Gly Arg Glu Ile Gln Gln Leu Ser Met
        115                 120                 125             
Ala Gly Cys Tyr Trp Leu Pro Gly Ser Thr Val Glu His Val Ala Arg
    130                 135                 140                 
Cys Arg Ser Leu Val Lys Val Asn Leu Ser Gly Cys His Leu Thr Ser
145                 150                 155                 160 
Leu Arg Leu Ser Lys Met Leu Ser Ala Leu Gln His Leu Arg Ser Leu
                165                 170                 175     
Ala Ile Asp Val Ser Pro Gly Phe Asp Ala Ser Gln Leu Ser Ser Glu
            180                 185                 190         
Cys Lys Ala Thr Leu Ser Arg Val Arg Glu Leu Lys Gln Thr Leu Phe
        195                 200                 205             
Thr Pro Ser Tyr Gly Val Val Pro Cys Cys Thr Ser Leu Glu Lys Leu
    210                 215                 220                 
Leu Leu Tyr Phe Glu Ile Leu Asp Arg Thr Arg Glu Gly Ala Ile Leu
225                 230                 235                 240 
Ser Gly Gln Leu Met Val Gly Gln Ser Asn Val Pro His Tyr Gln Asn
                245                 250                 255     
Leu Arg Val Phe Tyr Ala Arg Leu Ala Pro Gly Tyr Ile Asn Gln Glu
            260                 265                 270         
Val Val Arg Leu Tyr Leu Ala Val Leu Ser Asp Arg Thr Pro Gln Asn
        275                 280                 285             
Leu His Ala Phe Leu Ile Ser Val Pro Gly Ser Phe Ala Glu Ser Gly
    290                 295                 300                 
Ala Thr Lys Asn Leu Leu Asp Ser Met Ala Arg Asn Val Val Leu Asp
305                 310                 315                 320 
Ala Leu Gln Leu Pro Lys Ser Trp Leu Asn Gly Ser Ser Leu Leu Gln
                325                 330                 335     
His Met Lys Phe Asn Asn Pro Phe Tyr Phe Ser Phe Ser Arg Cys Thr
            340                 345                 350         
Leu Ser Gly Gly His Leu Ile Gln Gln Val Ile Asn Gly Gly Lys Asp
        355                 360                 365             
Leu Arg Ser Leu Ala Ser Leu Asn Leu Ser Gly Cys Val His Cys Leu
    370                 375                 380                 
Ser Pro Asp Ser Leu Leu Arg Lys Ala Glu Asp Asp Ile Asp Ser Ser
385                 390                 395                 400 
Ile Leu Glu Thr Leu Val Ala Ser Cys Cys Asn Leu Arg His Leu Asn
                405                 410                 415     
Leu Ser Ala Ala His His His Ser Ser Glu Gly Leu Gly Arg His Leu
            420                 425                 430         
Cys Gln Leu Leu Ala Arg Leu Arg His Leu Arg Ser Leu Ser Leu Pro
        435                 440                 445             
Val Cys Ser Val Ala Asp Ser Ala Pro Arg Ala Asp Arg Ala Pro Ala
    450                 455                 460                 
Gln Pro Ala Met His Ala Val Pro Arg Gly Phe Gly Lys Lys Val Arg
465                 470                 475                 480 
Val Gly Val Gln Ser Cys Pro Ser Pro Phe Ser Gly Gln Ala Cys Pro
                485                 490                 495     
Gln Pro Ser Ser Val Phe Trp Ser Leu Leu Lys Asn Leu Pro Phe Leu
            500                 505                 510         
Glu His Leu Glu Leu Ile Gly Ser Asn Phe Ser Ser Ala Met Pro Arg
        515                 520                 525             
Asn Glu Pro Ala Ile Arg Asn Ser Leu Pro Pro Cys Ser Arg Ala Gln
    530                 535                 540                 
Ser Val Gly Asp Ser Glu Val Ala Ala Ile Gly Gln Leu Ala Phe Leu
545                 550                 555                 560 
Arg His Leu Thr Leu Ala Gln Leu Pro Ser Val Leu Thr Gly Ser Gly
                565                 570                 575     
Leu Val Asn Ile Gly Leu Gln Cys Gln Gln Leu Arg Ser Leu Ser Leu
            580                 585                 590         
Ala Asn Leu Gly Met Met Gly Lys Val Val Tyr Met Pro Ala Leu Ser
        595                 600                 605             
Asp Met Leu Lys His Cys Lys Arg Leu Arg Asp Leu Arg Leu Glu Gln
    610                 615                 620                 
Pro Tyr Phe Ser Ala Asn Ala Gln Phe Phe Gln Ala Leu Ser Gln Cys
625                 630                 635                 640 
Pro Ser Leu Gln Arg Leu Cys Leu Val Ser Arg Ser Gly Thr Leu Gln
                645                 650                 655     
Pro Asp Ala Val Leu Ala Phe Met Ala Arg Cys Leu Gln Val Val Met
            660                 665                 670         
Cys His Leu Phe Thr Gly Glu Ser Leu Ala Thr Cys Lys Ser Leu Gln
        675                 680                 685             
Gln Ser Leu Leu Arg Ser Arg
    690                 695 


<210> 8108
<211> 1561
<212> PRT
<213> Homo sapiens

<400> 8108
Arg Gln Ile Cys Ser Met Ala Ser Glu Leu Gly Ala Arg Asp Asp Gly
 1               5                  10                  15      
Gly Cys Thr Glu Leu Ala Lys Pro Leu Tyr Leu Gln Tyr Leu Glu Arg
            20                  25                  30          
Ala Leu Arg Leu Asp His Phe Leu Arg Gln Thr Ser Ala Ile Phe Asn
        35                  40                  45              
Arg Asn Ile Ser Ser Asp Asp Ser Glu Asp Gly Leu Asp Asp Ser Asn
    50                  55                  60                  
Pro Leu Leu Pro Gln Ser Gly Asp Pro Leu Ile Gln Val Lys Glu Glu
65                  70                  75                  80  
Pro Pro Asn Ser Leu Leu Gly Glu Thr Ser Gly Ala Gly Ser Ser Gly
                85                  90                  95      
Met Leu Asn Thr Tyr Ser Leu Asn Gly Val Leu Gln Ser Glu Ser Lys
            100                 105                 110         
Cys Asp Lys Gly Asn Leu Tyr Asn Phe Ser Lys Leu Lys Lys Ser Arg
        115                 120                 125             
Lys Trp Leu Lys Ser Ile Leu Leu Ser Asp Glu Ser Ser Glu Ala Asp
    130                 135                 140                 
Ser Gln Ser Glu Asp Asp Asp Glu Glu Glu Leu Asn Leu Ser Arg Glu
145                 150                 155                 160 
Glu Leu His Asn Met Leu Arg Leu His Lys Tyr Lys Lys Leu His Gln
                165                 170                 175     
Asn Lys Tyr Ser Lys Asp Lys Glu Leu Gln Gln Tyr Gln Tyr Tyr Ser
            180                 185                 190         
Ala Gly Leu Leu Ser Thr Tyr Asp Pro Phe Tyr Glu Gln Gln Arg His
        195                 200                 205             
Leu Leu Gly Pro Lys Lys Lys Lys Phe Lys Glu Glu Lys Lys Leu Lys
    210                 215                 220                 
Ala Lys Leu Lys Lys Val Lys Lys Lys Arg Arg Arg Asp Glu Glu Leu
225                 230                 235                 240 
Ser Ser Glu Glu Ser Pro Arg Arg His His His Gln Thr Lys Val Phe
                245                 250                 255     
Ala Lys Phe Ser His Asp Ala Pro Pro Pro Gly Thr Lys Lys Lys His
            260                 265                 270         
Leu Ser Ile Glu Gln Leu Asn Ala Arg Arg Arg Lys Val Trp Leu Ser
        275                 280                 285             
Ile Val Lys Lys Glu Leu Pro Lys Ala Asn Lys Gln Lys Ala Ser Ala
    290                 295                 300                 
Arg Asn Leu Phe Leu Thr Asn Ser Arg Lys Leu Ala His Gln Cys Met
305                 310                 315                 320 
Lys Glu Val Arg Arg Ala Ala Leu Gln Ala Gln Lys Asn Cys Lys Glu
                325                 330                 335     
Thr Leu Pro Arg Ala Arg Arg Leu Thr Lys Glu Met Leu Leu Tyr Trp
            340                 345                 350         
Lys Lys Tyr Glu Lys Val Glu Lys Glu His Arg Lys Arg Ala Glu Lys
        355                 360                 365             
Glu Ala Leu Glu Gln Arg Lys Leu Asp Glu Glu Met Arg Glu Ala Lys
    370                 375                 380                 
Arg Gln Gln Arg Lys Leu Asn Phe Leu Ile Thr Gln Thr Glu Leu Tyr
385                 390                 395                 400 
Ala His Phe Met Ser Arg Lys Arg Asp Met Gly His Asp Gly Ile Gln
                405                 410                 415     
Glu Glu Ile Leu Arg Lys Leu Glu Asp Ser Ser Thr Gln Arg Gln Ile
            420                 425                 430         
Asp Ile Gly Gly Gly Val Val Val Asn Ile Thr Gln Glu Asp Tyr Asp
        435                 440                 445             
Ser Asn His Phe Lys Ala Gln Ala Leu Lys Asn Ala Glu Asn Ala Tyr
    450                 455                 460                 
His Ile His Gln Ala Arg Thr Arg Ser Phe Asp Glu Asp Ala Lys Glu
465                 470                 475                 480 
Ser Arg Ala Ala Ala Leu Arg Ala Ala Asn Lys Ser Gly Thr Gly Phe
                485                 490                 495     
Gly Glu Ser Tyr Ser Leu Ala Asn Pro Ser Ile Arg Ala Gly Glu Asp
            500                 505                 510         
Ile Pro Gln Pro Thr Ile Phe Asn Gly Lys Leu Lys Gly Tyr Gln Leu
        515                 520                 525             
Lys Gly Met Asn Trp Leu Ala Asn Leu Tyr Glu Gln Gly Ile Asn Gly
    530                 535                 540                 
Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Gln Ser Ile Ala
545                 550                 555                 560 
Leu Leu Ala His Leu Ala Glu Arg Glu Asn Ile Trp Gly Pro Phe Leu
                565                 570                 575     
Ile Ile Ser Pro Ala Ser Thr Leu Asn Asn Trp His Gln Glu Phe Thr
            580                 585                 590         
Arg Phe Val Pro Lys Phe Lys Val Leu Pro Tyr Trp Gly Asn Pro His
        595                 600                 605             
Asp Arg Lys Val Ile Arg Arg Phe Trp Ser Gln Lys Thr Leu Tyr Thr
    610                 615                 620                 
Gln Asp Ala Pro Phe His Val Val Ile Thr Ser Tyr Gln Leu Val Val
625                 630                 635                 640 
Gln Asp Val Lys Tyr Phe Gln Arg Val Lys Trp Gln Tyr Met Val Leu
                645                 650                 655     
Asp Glu Ala Gln Ala Leu Lys Ser Ser Ser Ser Val Arg Trp Lys Ile
            660                 665                 670         
Leu Leu Gln Phe Gln Cys Arg Asn Arg Leu Leu Leu Thr Gly Thr Pro
        675                 680                 685             
Ile Gln Asn Thr Met Ala Glu Leu Trp Ala Leu Leu His Phe Ile Met
    690                 695                 700                 
Pro Thr Leu Phe Asp Ser His Glu Glu Phe Asn Glu Trp Phe Ser Lys
705                 710                 715                 720 
Asp Ile Glu Ser His Ala Glu Asn Lys Ser Ala Ile Asp Glu Asn Gln
                725                 730                 735     
Leu Ser Arg Leu His Met Ile Leu Lys Pro Phe Met Leu Arg Arg Ile
            740                 745                 750         
Lys Lys Asp Val Glu Asn Glu Leu Ser Asp Lys Ile Glu Ile Leu Met
        755                 760                 765             
Tyr Cys Gln Leu Thr Ser Arg Gln Lys Leu Leu Tyr Gln Ala Leu Lys
    770                 775                 780                 
Asn Lys Ile Ser Ile Glu Asp Leu Leu Gln Ser Ser Met Gly Ser Thr
785                 790                 795                 800 
Gln Gln Ala Gln Asn Thr Thr Ser Ser Leu Met Asn Leu Val Met Gln
                805                 810                 815     
Phe Arg Lys Val Cys Asn His Pro Glu Leu Phe Glu Arg Gln Glu Thr
            820                 825                 830         
Trp Ser Pro Phe His Ile Ser Leu Lys Pro Tyr His Ile Ser Lys Phe
        835                 840                 845             
Ile Tyr Arg His Gly Gln Ile Arg Val Phe Asn His Ser Arg Asp Arg
    850                 855                 860                 
Trp Leu Arg Val Leu Ser Pro Phe Ala Pro Asp Tyr Ile Gln Arg Ser
865                 870                 875                 880 
Leu Phe His Arg Lys Gly Ile Asn Glu Glu Ser Cys Phe Ser Phe Leu
                885                 890                 895     
Arg Phe Ile Asp Ile Ser Pro Ala Glu Met Ala Asn Leu Met Leu Gln
            900                 905                 910         
Gly Leu Leu Ala Arg Trp Leu Ala Leu Phe Leu Ser Leu Lys Ala Ser
        915                 920                 925             
Tyr Arg Leu His Gln Leu Arg Ser Trp Gly Ala Pro Glu Gly Glu Ser
    930                 935                 940                 
His Gln Arg Tyr Leu Arg Asn Lys Asp Phe Leu Leu Gly Val Asn Phe
945                 950                 955                 960 
Pro Leu Ser Phe Pro Asn Leu Cys Ser Cys Pro Leu Leu Lys Ser Leu
                965                 970                 975     
Val Phe Ser Ser His Cys Lys Ala Val Ser Gly Tyr Ser Asp Gln Val
            980                 985                 990         
Val His Gln Arg Arg Ser Ala Thr Ser Ser Leu Arg Arg Cys Leu Leu
        995                 1000                1005            
Thr Glu Leu Pro Ser Phe Leu Cys Val Ala Ser Pro Arg Val Thr Ala
    1010                1015                1020                
Val Pro Leu Asp Ser Tyr Cys Asn Asp Arg Ser Ala Glu Tyr Glu Arg
1025                1030                1035                1040
Arg Val Leu Lys Glu Gly Gly Ser Leu Ala Ala Lys Gln Cys Leu Leu
                1045                1050                1055    
Asn Gly Ala Pro Glu Leu Ala Ala Asp Trp Leu Asn Arg Arg Ser Gln
            1060                1065                1070        
Phe Phe Pro Glu Pro Ala Gly Gly Leu Trp Ser Ile Arg Pro Gln Asn
        1075                1080                1085            
Gly Trp Ser Phe Ile Arg Ile Pro Gly Lys Glu Ser Leu Ile Thr Asp
    1090                1095                1100                
Ser Gly Lys Leu Tyr Ala Leu Asp Val Leu Leu Thr Arg Leu Lys Ser
1105                1110                1115                1120
Gln Gly His Arg Val Leu Ile Tyr Ser Gln Met Thr Arg Met Ile Asp
                1125                1130                1135    
Leu Leu Glu Glu Tyr Met Val Tyr Arg Lys His Thr Tyr Met Arg Leu
            1140                1145                1150        
Asp Gly Ser Ser Lys Ile Ser Glu Arg Arg Asp Met Val Ala Asp Phe
        1155                1160                1165            
Gln Asn Arg Asn Asp Ile Phe Val Phe Leu Leu Ser Thr Arg Ala Gly
    1170                1175                1180                
Gly Leu Gly Ile Asn Leu Thr Ala Ala Asp Thr Val Ile Phe Tyr Asp
1185                1190                1195                1200
Ser Asp Trp Asn Pro Thr Val Asp Gln Gln Ala Met Asp Arg Ala His
                1205                1210                1215    
Arg Leu Gly Gln Thr Lys Gln Val Thr Val Tyr Arg Leu Ile Cys Lys
            1220                1225                1230        
Gly Thr Ile Glu Glu Arg Ile Leu Gln Arg Ala Lys Glu Lys Ser Glu
        1235                1240                1245            
Ile Gln Arg Met Val Ile Ser Gly Gly Asn Phe Lys Pro Asp Thr Leu
    1250                1255                1260                
Lys Pro Lys Glu Val Val Ser Leu Leu Leu Asp Asp Glu Glu Leu Glu
1265                1270                1275                1280
Lys Lys Leu Arg Leu Arg Gln Glu Glu Lys Arg Gln Gln Glu Glu Thr
                1285                1290                1295    
Asn Arg Val Lys Glu Arg Lys Arg Lys Arg Glu Lys Tyr Ala Glu Lys
            1300                1305                1310        
Lys Lys Lys Glu Asp Glu Leu Asp Gly Lys Arg Arg Lys Glu Gly Val
        1315                1320                1325            
Asn Leu Val Ile Pro Phe Val Pro Ser Ala Asp Asn Ser Asn Leu Ser
    1330                1335                1340                
Ala Asp Gly Asp Asp Ser Phe Ile Ser Val Asp Ser Ala Met Pro Ser
1345                1350                1355                1360
Pro Phe Ser Glu Ile Ser Ile Ser Ser Glu Leu His Thr Gly Ser Ile
                1365                1370                1375    
Pro Leu Asp Glu Ser Ser Ser Asp Met Leu Val Ile Val Asp Asp Pro
            1380                1385                1390        
Ala Ser Ser Ala Pro Gln Ser Arg Ala Thr Asn Ser Pro Ala Ser Ile
        1395                1400                1405            
Thr Gly Ser Val Ser Asp Thr Val Asn Gly Ile Ser Ile Gln Glu Met
    1410                1415                1420                
Pro Ala Ala Gly Arg Gly His Ser Ala Arg Ser Arg Gly Arg Pro Lys
1425                1430                1435                1440
Gly Ser Gly Ser Thr Ala Lys Gly Ala Gly Lys Gly Arg Ser Arg Lys
                1445                1450                1455    
Ser Thr Ala Gly Ser Ala Ala Ala Met Ala Gly Ala Lys Ala Gly Ala
            1460                1465                1470        
Ala Ala Ala Ser Ala Ala Ala Tyr Ala Ala Tyr Gly Tyr Asn Val Ser
        1475                1480                1485            
Lys Gly Ile Ser Ala Ser Ser Pro Leu Gln Thr Ser Leu Val Arg Pro
    1490                1495                1500                
Ala Gly Leu Ala Asp Phe Gly Pro Ser Ser Ala Ser Ser Pro Leu Ser
1505                1510                1515                1520
Ser Pro Leu Ser Lys Gly Asn Asn Val Pro Gly Asn Pro Lys Asn Leu
                1525                1530                1535    
His Met Thr Ser Ser Leu Ala Pro Asp Ser Leu Val Arg Lys Gln Gly
            1540                1545                1550        
Lys Gly Thr Asn Pro Ser Gly Gly Arg
        1555                1560    


<210> 8109
<211> 509
<212> PRT
<213> Homo sapiens

<400> 8109
Ala Gln Ser Lys Leu Met Ser Pro Glu Thr Thr Leu Gly Thr Arg Thr
 1               5                  10                  15      
Lys Asp Ser Leu Asn Pro Glu Gln Gly Leu Pro Pro Ala His Pro Leu
            20                  25                  30          
Gly Ser Gly Asp Ser Cys Ser Pro Trp Ser Gln Asp Gly Arg Ala Gln
        35                  40                  45              
Arg Gly Asp Pro Ser Leu Pro Arg Gly Val Gly Ser Arg Gly Thr Asp
    50                  55                  60                  
Pro Cys Ser Ser Ala Phe Ser Asn Thr Ala Trp Gly Val Ser Pro Lys
65                  70                  75                  80  
Gln Lys Gly Glu Glu Gly Ala Pro Arg Glu Arg Val His Arg Glu Glu
                85                  90                  95      
Glu Arg Thr Ala Phe His Leu Ser Asp Thr Val Pro Ala Ser Ser Ala
            100                 105                 110         
Ser Lys Asn Lys Ala Gln Asn Ile Thr Ala Pro Glu Ser Glu Ala Ile
        115                 120                 125             
Cys Trp Gln Leu Leu Ser Arg Cys Phe Arg Ser Trp Arg His Leu Val
    130                 135                 140                 
Lys Arg Gln Arg Glu Pro Ala Ala Ala Ala Val Ala Leu Gly Arg Trp
145                 150                 155                 160 
Gln Leu Leu Gln Lys Cys Leu Gln Ala Leu Trp Leu Arg Glu Ala Gln
                165                 170                 175     
Leu Glu Ala Ala Trp Gly Gln Tyr Thr Lys Val Leu Leu Val Gln Ser
            180                 185                 190         
Phe Arg Glu Trp Arg Asn Leu Ala Leu Gln Gln Lys Gln Val Gln Pro
        195                 200                 205             
His Met Gln Ala Gly Pro Gly Ser Pro Pro Ser Arg Arg Ala Gln Gly
    210                 215                 220                 
Lys Gly Leu Ser Leu Gly Arg Ser Thr Val Val Asp Pro Ala Gln Arg
225                 230                 235                 240 
Ser Arg Leu Glu His Thr Ser Pro Gly Ser Leu Arg Glu Glu Glu Ile
                245                 250                 255     
Ala Gln Trp Leu Leu Ser His Pro Arg Gln Arg Thr Asp Ser Arg His
            260                 265                 270         
Glu Arg Val Gln Ile Leu Gln Ala Leu Gln Leu Ala Val Phe Phe Leu
        275                 280                 285             
Trp Cys Gln Gln Lys Lys Arg Ala Arg Gln Glu Arg Glu Thr Leu Arg
    290                 295                 300                 
Lys Ala Thr Arg Ala Thr Gln Arg Thr Gly Ser Phe Pro Gln Ala Trp
305                 310                 315                 320 
His Ser Thr Ala Ala Gly Val Ala Trp Val Ala Pro Leu Ser Pro Gln
                325                 330                 335     
His Gln Arg Ala Trp Leu Cys Arg Cys Phe Gly Ala Trp Gln Gln Phe
            340                 345                 350         
Val Gln Arg Gly Ser Arg Tyr Arg Asp His Leu Ala Asp Arg Arg Thr
        355                 360                 365             
Gly Thr Leu Arg Lys Cys Leu Glu Gln Trp Val Arg Met Lys Gln Leu
    370                 375                 380                 
Arg Glu Ser Asp Gly Ala Lys Val Thr Gln Leu Ser Leu Cys Arg Gln
385                 390                 395                 400 
Lys Ala Gly Arg Glu Ala Val Tyr Thr Ala Gly Pro Gly Ala Cys Gly
                405                 410                 415     
Leu Gly Ala Val Gly Gln Ala Gln Gly Gln Gln Glu Gln Gly Arg Gly
            420                 425                 430         
Ser Leu Gln Asp Ala Cys Arg Thr Leu Ala Leu Cys Trp Ala Leu Leu
        435                 440                 445             
Leu Trp Lys Met Arg Leu Phe Gln Cys Gln Trp Ala Lys Glu Thr Glu
    450                 455                 460                 
Ala Gln Arg Ala Gly Ala Ala Cys Cys Lys Ser Gln Trp Glu Ser Gly
465                 470                 475                 480 
Ala Arg Arg Ser Cys Val Glu Thr Trp Val Leu Pro Pro His Lys Met
                485                 490                 495     
Val Thr Ala Gly Ile Arg Ser Pro Glu Glu Gly Cys Arg
            500                 505                 


<210> 8110
<211> 149
<212> PRT
<213> Homo sapiens

<400> 8110
Met Pro Pro Lys Phe Asp Pro Asn Glu Ile Lys Val Ile Tyr Leu Arg
 1               5                  10                  15      
Cys Thr Gly Asp Ala Thr Ser Ala Leu Ala Pro Lys Ile Gly Pro Leu
            20                  25                  30          
Gly Leu Ser Pro Lys Asn Val Gly Gly Asp Ile Ala Lys Ala Thr Gly
        35                  40                  45              
Asp Trp Lys Gly Leu Arg Ile Thr Val Lys Leu Thr Ile Gln Asn Arg
    50                  55                  60                  
Gln Ala Gln Ile Glu Val Val Pro Ser Ala Ser Ala Leu Ile Ile Lys
65                  70                  75                  80  
Ala Leu Lys Glu Pro Pro Glu Thr Glu Arg Asn Arg Lys Asn Ile Lys
                85                  90                  95      
His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn Leu Ala Arg Gln
            100                 105                 110         
Met Glu His Arg Ser Leu Ala Arg Glu Leu Ser Gly Thr Ile Lys Glu
        115                 120                 125             
Ile Leu Gly Thr Ala Gln Ser Leu Trp Val Val Met Leu Met Ala Ala
    130                 135                 140                 
Thr Leu Met Thr Ser
145                 


<210> 8111
<211> 320
<212> PRT
<213> Homo sapiens

<400> 8111
Met Ala Phe Pro Lys Lys Lys Leu Gln Gly Leu Val Ala Ala Thr Ile
 1               5                  10                  15      
Thr Pro Met Thr Glu Asn Gly Glu Ile Asn Phe Ser Val Ile Gly Gln
            20                  25                  30          
Tyr Val Asp Tyr Leu Val Lys Glu Gln Gly Val Lys Asn Ile Phe Val
        35                  40                  45              
Asn Gly Thr Thr Gly Glu Gly Leu Ser Leu Ser Val Ser Glu Arg Arg
    50                  55                  60                  
Gln Val Ala Glu Glu Trp Val Thr Lys Gly Lys Asp Lys Leu Asp Gln
65                  70                  75                  80  
Val Ile Ile His Val Gly Ala Leu Ser Leu Lys Glu Ser Gln Glu Leu
                85                  90                  95      
Ala Gln His Ala Ala Glu Ile Gly Ala Asp Gly Ile Ala Val Ile Ala
            100                 105                 110         
Pro Phe Phe Leu Lys Pro Trp Thr Lys Asp Ile Leu Ile Asn Phe Leu
        115                 120                 125             
Lys Glu Val Ala Ala Ala Ala Pro Ala Leu Pro Phe Tyr Tyr Tyr His
    130                 135                 140                 
Ile Pro Ala Leu Thr Gly Val Lys Ile Arg Ala Glu Glu Leu Leu Asp
145                 150                 155                 160 
Gly Ile Leu Asp Lys Ile Pro Thr Phe Gln Gly Leu Lys Phe Ser Asp
                165                 170                 175     
Thr Asp Leu Leu Asp Phe Gly Gln Cys Val Asp Gln Asn Arg Gln Gln
            180                 185                 190         
Gln Phe Ala Phe Leu Phe Gly Val Asp Glu Gln Leu Leu Ser Ala Leu
        195                 200                 205             
Val Met Gly Ala Thr Gly Ala Val Gly Ser Thr Tyr Asn Tyr Leu Gly
    210                 215                 220                 
Lys Lys Thr Asn Gln Met Leu Glu Ala Phe Glu Gln Lys Asp Phe Ser
225                 230                 235                 240 
Leu Ala Leu Asn Tyr Gln Phe Cys Ile Gln Arg Phe Ile Asn Phe Val
                245                 250                 255     
Val Lys Leu Gly Phe Gly Val Ser Gln Thr Lys Ala Ile Met Thr Leu
            260                 265                 270         
Val Ser Gly Ile Pro Met Gly Pro Pro Arg Leu Pro Leu Gln Lys Ala
        275                 280                 285             
Ser Arg Glu Phe Thr Asp Ser Ala Glu Ala Lys Leu Lys Ser Leu Asp
    290                 295                 300                 
Phe Leu Ser Phe Thr Asp Leu Lys Asp Gly Asn Leu Glu Ala Gly Ser
305                 310                 315                 320 


<210> 8112
<211> 303
<212> PRT
<213> Homo sapiens

<400> 8112
Met Leu Gly Arg Ser Leu Arg Glu Val Ser Ala Ala Leu Lys Gln Gly
 1               5                  10                  15      
Gln Ile Thr Pro Thr Glu Leu Cys Gln Lys Cys Leu Ser Leu Ile Lys
            20                  25                  30          
Lys Thr Lys Phe Leu Asn Ala Tyr Ile Thr Val Ser Glu Glu Val Ala
        35                  40                  45              
Leu Lys Gln Ala Glu Glu Ser Glu Lys Arg Tyr Lys Asn Gly Gln Ser
    50                  55                  60                  
Leu Gly Asp Leu Asp Gly Ile Pro Ile Ala Val Lys Asp Asn Phe Ser
65                  70                  75                  80  
Thr Ser Gly Ile Glu Thr Thr Cys Ala Ser Asn Met Leu Lys Gly Tyr
                85                  90                  95      
Ile Pro Pro Tyr Asn Ala Thr Val Val Gln Lys Leu Leu Asp Gln Gly
            100                 105                 110         
Ala Leu Leu Met Gly Lys Thr Asn Leu Asp Glu Phe Ala Met Gly Ser
        115                 120                 125             
Gly Ser Thr Asp Gly Val Phe Gly Pro Val Lys Asn Pro Trp Ser Tyr
    130                 135                 140                 
Ser Lys Gln Tyr Arg Glu Lys Arg Lys Gln Asn Pro His Ser Glu Asn
145                 150                 155                 160 
Glu Asp Ser Asp Trp Leu Ile Thr Gly Gly Ser Ser Gly Gly Ser Ala
                165                 170                 175     
Ala Ala Val Ser Ala Phe Thr Cys Tyr Ala Ala Leu Gly Ser Asp Thr
            180                 185                 190         
Gly Gly Ser Thr Arg Asn Pro Ala Ala His Cys Gly Leu Val Gly Phe
        195                 200                 205             
Lys Pro Ser Tyr Gly Leu Val Ser Arg His Gly Leu Ile Pro Leu Val
    210                 215                 220                 
Asn Ser Met Asp Val Pro Gly Ile Leu Thr Arg Cys Val Asp Asp Ala
225                 230                 235                 240 
Ala Ile Val Leu Gly Ala Leu Ala Gly Pro Asp Pro Arg Asp Ser Thr
                245                 250                 255     
Thr Val His Glu Pro Ile Asn Lys Pro Phe Met Leu Pro Ser Leu Ala
            260                 265                 270         
Asp Val Ser Lys Leu Cys Ile Gly Ile Pro Lys Val Thr Phe Ser Phe
        275                 280                 285             
His Tyr Phe Thr Glu Ile Leu Ser Ser Pro Ile Glu Ser Thr Asp
    290                 295                 300             


<210> 8113
<211> 528
<212> PRT
<213> Homo sapiens

<400> 8113
Met Leu Gly Arg Ser Leu Arg Glu Val Ser Ala Ala Leu Lys Gln Gly
 1               5                  10                  15      
Gln Ile Thr Pro Thr Glu Leu Cys Gln Lys Cys Leu Ser Leu Ile Lys
            20                  25                  30          
Lys Ala Lys Phe Leu Asn Ala Tyr Ile Thr Val Ser Glu Glu Val Ala
        35                  40                  45              
Leu Lys Gln Ala Glu Glu Ser Glu Lys Arg Tyr Lys Asn Gly Gln Ser
    50                  55                  60                  
Leu Gly Asp Leu Asp Gly Ile Pro Ile Ala Val Lys Asp Asn Phe Ser
65                  70                  75                  80  
Thr Ser Gly Ile Glu Thr Thr Cys Ala Ser Asn Met Leu Lys Gly Tyr
                85                  90                  95      
Ile Pro Pro Tyr Asn Ala Thr Val Val Gln Lys Leu Leu Asp Gln Gly
            100                 105                 110         
Ala Leu Leu Met Gly Lys Thr Asn Leu Asp Glu Phe Ala Met Gly Ser
        115                 120                 125             
Gly Ser Thr Asp Gly Val Phe Gly Pro Val Lys Asn Pro Trp Ser Tyr
    130                 135                 140                 
Ser Lys Arg Tyr Arg Glu Lys Arg Lys Gln Asn Pro His Ser Glu Asn
145                 150                 155                 160 
Glu Asp Ser Asp Trp Leu Ile Thr Gly Gly Ser Pro Gly Gly Ser Ala
                165                 170                 175     
Ala Ala Val Ser Ala Phe Thr Cys Tyr Ala Ala Leu Gly Ser Asp Thr
            180                 185                 190         
Gly Gly Ser Thr Arg Asn Pro Ala Ala His Cys Gly Leu Val Gly Phe
        195                 200                 205             
Lys Pro Ser Tyr Gly Leu Val Ser Arg His Gly Leu Ile Pro Leu Val
    210                 215                 220                 
Asn Ser Met Asp Val Pro Gly Ile Leu Thr Arg Cys Val Asp Asp Ala
225                 230                 235                 240 
Ala Ile Val Leu Gly Ala Leu Ala Gly Pro Asp Pro Arg Asp Ser Thr
                245                 250                 255     
Thr Val His Glu Pro Ile Asn Lys Pro Phe Met Leu Pro Ser Leu Ala
            260                 265                 270         
Asp Val Ser Lys Leu Cys Ile Gly Ile Pro Lys Glu Tyr Leu Val Pro
        275                 280                 285             
Glu Leu Ser Ser Glu Val Gln Ser Leu Trp Ser Lys Ala Ala Asp Leu
    290                 295                 300                 
Phe Glu Ser Glu Gly Ala Lys Val Ile Glu Val Ser Leu Pro His Thr
305                 310                 315                 320 
Ser Tyr Ser Ile Val Cys Tyr His Val Leu Cys Thr Ser Glu Val Ala
                325                 330                 335     
Ser Asn Met Ala Arg Phe Asp Gly Leu Gln Tyr Gly His Arg Cys Asp
            340                 345                 350         
Ile Asp Val Ser Thr Glu Ala Met Tyr Ala Ala Thr Arg Arg Glu Gly
        355                 360                 365             
Phe Asn Asp Val Val Arg Gly Arg Ile Leu Ser Gly Asn Phe Phe Leu
    370                 375                 380                 
Leu Lys Glu Asn Tyr Glu Asn Tyr Phe Val Lys Ala Gln Lys Val Arg
385                 390                 395                 400 
Arg Leu Ile Ala Asn Asp Phe Val Asn Ala Phe Asn Ser Gly Val Asp
                405                 410                 415     
Val Leu Leu Thr Pro Thr Thr Leu Ser Glu Ala Val Pro Tyr Leu Glu
            420                 425                 430         
Phe Ile Lys Glu Asp Asn Arg Thr Arg Ser Ala Gln Asp Asp Ile Phe
        435                 440                 445             
Thr Gln Ala Val Asn Met Ala Gly Leu Pro Ala Val Ser Ile Pro Val
    450                 455                 460                 
Ala Leu Ser Asn Gln Gly Leu Pro Ile Gly Leu Gln Phe Ile Gly Arg
465                 470                 475                 480 
Ala Phe Cys Asp Gln Gln Leu Leu Thr Val Ala Lys Trp Phe Glu Lys
                485                 490                 495     
Gln Val Gln Phe Pro Val Ile Gln Leu Gln Glu Leu Met Asp Asp Cys
            500                 505                 510         
Ser Ala Val Leu Glu Asn Glu Lys Leu Ala Ser Val Ser Leu Lys Gln
        515                 520                 525             


<210> 8114
<211> 513
<212> PRT
<213> Homo sapiens

<400> 8114
Met Ala Met Glu Ile Asp Ser Arg Pro Gly Gly Leu Pro Gly Ser Ser
 1               5                  10                  15      
Cys Asn Leu Gly Ala Ala Arg Glu His Met Gln Ala Val Thr Arg Asn
            20                  25                  30          
Tyr Ile Thr His Pro Arg Val Thr Tyr Arg Thr Val Cys Ser Val Asn
        35                  40                  45              
Gly Pro Leu Val Val Leu Asp Arg Val Lys Phe Ala Gln Tyr Ala Glu
    50                  55                  60                  
Ile Val His Phe Thr Leu Pro Asp Gly Thr Gln Arg Ser Gly Gln Val
65                  70                  75                  80  
Leu Glu Val Ala Gly Thr Lys Ala Ile Val Gln Val Phe Glu Gly Thr
                85                  90                  95      
Ser Gly Ile Asp Ala Arg Lys Thr Thr Cys Glu Phe Thr Gly Asp Ile
            100                 105                 110         
Leu Arg Thr Pro Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn Gly
        115                 120                 125             
Ser Gly Lys Pro Ile Asp Lys Gly Pro Val Val Met Ala Glu Asp Phe
    130                 135                 140                 
Leu Asp Ile Asn Gly Gln Pro Ile Asn Pro His Ser Arg Ile Tyr Pro
145                 150                 155                 160 
Glu Glu Met Ile Gln Thr Gly Ile Ser Pro Ile Asp Val Met Asn Ser
                165                 170                 175     
Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu Pro
            180                 185                 190         
His Asn Glu Ile Ala Ala Gln Ile Cys Arg Gln Ala Gly Leu Val Lys
        195                 200                 205             
Lys Ser Lys Ala Val Leu Asp Tyr His Asp Asp Asn Phe Ala Ile Val
    210                 215                 220                 
Phe Ala Ala Met Gly Val Asn Met Glu Thr Ala Arg Phe Phe Lys Ser
225                 230                 235                 240 
Asp Phe Glu Gln Asn Gly Thr Met Gly Asn Val Cys Leu Phe Leu Asn
                245                 250                 255     
Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile Ile Thr Pro Arg Leu Ala
            260                 265                 270         
Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln Cys Glu Lys His Val Leu
        275                 280                 285             
Val Ile Leu Thr Asp Met Ser Ser Tyr Ala Glu Ala Leu Arg Glu Val
    290                 295                 300                 
Ser Ala Ala Arg Glu Glu Val Pro Gly Arg Arg Gly Phe Pro Gly Tyr
305                 310                 315                 320 
Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu Arg Ala Gly Arg Val Glu
                325                 330                 335     
Gly Arg Gly Gly Ser Ile Thr Gln Ile Pro Ile Leu Thr Met Pro Asn
            340                 345                 350         
Asp Asp Ile Thr His Pro Ile Pro Asp Leu Thr Gly Phe Ile Thr Glu
        355                 360                 365             
Gly Gln Ile Tyr Val Asp Arg Gln Leu His Asn Arg Gln Ile Tyr Pro
    370                 375                 380                 
Pro Ile Asn Val Leu Pro Ser Leu Ser Arg Leu Met Lys Ser Ala Ile
385                 390                 395                 400 
Gly Glu Gly Met Thr Arg Lys Asp His Gly Asp Val Ser Asn Gln Leu
                405                 410                 415     
Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val Gln Ala Met Lys Ala Val
            420                 425                 430         
Val Gly Glu Glu Ala Leu Thr Ser Glu Asp Leu Leu Tyr Leu Glu Phe
        435                 440                 445             
Leu Gln Lys Phe Glu Lys Asn Phe Ile Asn Gln Gly Pro Tyr Glu Asn
    450                 455                 460                 
Arg Ser Met Phe Glu Ser Leu Asp Leu Ser Trp Lys Leu Leu Arg Ile
465                 470                 475                 480 
Phe Pro Lys Glu Met Leu Lys Arg Ile Pro Gln Ala Val Ile Asp Glu
                485                 490                 495     
Phe Tyr Ser Arg Glu Gly Arg Leu Gln Asp Leu Ala Pro Asp Thr Ala
            500                 505                 510         
Leu
    


<210> 8115
<211> 673
<212> PRT
<213> Homo sapiens

<400> 8115
Met Ala Lys Leu Glu Thr Leu Pro Val Arg Ala Asp Pro Gly Arg Asp
 1               5                  10                  15      
Pro Leu Leu Ala Phe Ala Pro Arg Pro Ser Glu Leu Gly Pro Pro Asp
            20                  25                  30          
Pro Arg Leu Ala Met Gly Ser Val Gly Ser Gly Val Ala His Ala Gln
        35                  40                  45              
Glu Phe Ala Met Lys Ser Val Gly Thr Arg Thr Gly Gly Gly Gly Ser
    50                  55                  60                  
Gln Gly Ser Phe Pro Gly Pro Arg Gly Ser Gly Ser Gly Ala Ser Arg
65                  70                  75                  80  
Glu Arg Pro Gly Arg Tyr Pro Ser Glu Asp Lys Gly Leu Ala Asn Ser
                85                  90                  95      
Leu Tyr Leu Asn Gly Glu Leu Arg Gly Ser Asp His Thr Asp Val Cys
            100                 105                 110         
Gly Asn Val Val Gly Ser Ser Gly Gly Ser Ser Ser Ser Gly Gly Ser
        115                 120                 125             
Asp Lys Ala Pro Pro Gln Tyr Arg Glu Pro Ser His Pro Pro Lys Leu
    130                 135                 140                 
Leu Ala Thr Ser Gly Lys Leu Asp Gln Cys Ser Glu Pro Leu Val Arg
145                 150                 155                 160 
Pro Ser Ala Phe Lys Pro Val Val Pro Lys Asn Phe His Ser Met Gln
                165                 170                 175     
Asn Leu Cys Pro Pro Gln Thr Asn Gly Thr Pro Glu Gly Arg Gln Gly
            180                 185                 190         
Pro Gly Gly Leu Lys Gly Gly Leu Asp Lys Ser Arg Thr Met Thr Pro
        195                 200                 205             
Ala Gly Gly Ser Gly Ser Gly Leu Ser Asp Ser Gly Arg Asn Ser Leu
    210                 215                 220                 
Thr Ser Leu Pro Thr Tyr Ser Ser Ser Tyr Ser Gln His Leu Ala Pro
225                 230                 235                 240 
Leu Ser Ala Ser Thr Ser His Ile Asn Arg Ile Gly Thr Ala Ser Tyr
                245                 250                 255     
Gly Ser Gly Ser Gly Gly Ser Ser Gly Gly Gly Ser Gly Tyr Gln Asp
            260                 265                 270         
Leu Gly Thr Ser Asp Ser Gly Arg Ala Ser Ser Lys Ser Gly Ser Ser
        275                 280                 285             
Ser Ser Met Gly Arg Pro Gly His Leu Gly Ser Gly Glu Gly Gly Gly
    290                 295                 300                 
Gly Gly Leu Pro Phe Ala Ala Cys Ser Pro Pro Ser Pro Ser Ala Leu
305                 310                 315                 320 
Ile Gln Glu Leu Glu Glu Arg Leu Trp Glu Lys Glu Gln Glu Val Ala
                325                 330                 335     
Ala Leu Arg Arg Ser Leu Glu Gln Ser Glu Ala Ala Val Ala Gln Val
            340                 345                 350         
Leu Glu Glu Arg Gln Lys Ala Trp Glu Arg Glu Leu Ala Glu Leu Arg
        355                 360                 365             
Gln Gly Cys Ser Gly Lys Leu Gln Gln Val Ala Arg Arg Ala Gln Arg
    370                 375                 380                 
Ala Gln Gln Gly Leu Gln Leu Gln Val Leu Arg Leu Gln Gln Asp Lys
385                 390                 395                 400 
Lys Gln Leu Gln Glu Glu Ala Ala Arg Leu Met Arg Gln Arg Glu Glu
                405                 410                 415     
Leu Glu Asp Lys Val Ala Ala Cys Gln Lys Glu Gln Ala Asp Phe Leu
            420                 425                 430         
Pro Arg Ile Glu Glu Thr Lys Trp Glu Val Cys Gln Lys Ala Gly Glu
        435                 440                 445             
Ile Ser Leu Leu Lys Gln Gln Leu Lys Asp Ser Gln Ala Asp Val Ser
    450                 455                 460                 
Gln Lys Leu Ser Glu Ile Val Gly Leu Arg Ser Gln Leu Arg Glu Gly
465                 470                 475                 480 
Arg Ala Ser Leu Arg Glu Lys Glu Glu Gln Leu Leu Ser Leu Arg Asp
                485                 490                 495     
Ser Phe Ser Ser Lys Gln Ala Ser Leu Glu Leu Gly Glu Gly Glu Leu
            500                 505                 510         
Pro Ala Ala Cys Leu Lys Pro Ala Leu Thr Pro Val Asp Pro Ala Glu
        515                 520                 525             
Pro Gln Asp Ala Leu Ala Thr Cys Glu Ser Asp Glu Ala Lys Met Arg
    530                 535                 540                 
Arg Gln Ala Gly Val Ala Ala Ala Ala Ser Leu Val Ser Val Asp Gly
545                 550                 555                 560 
Glu Ala Glu Ala Gly Gly Glu Ser Gly Thr Arg Ala Leu Arg Arg Glu
                565                 570                 575     
Val Gly Arg Leu Gln Ala Glu Leu Ala Ala Glu Arg Arg Ala Arg Glu
            580                 585                 590         
Arg Gln Gly Ala Ser Phe Ala Glu Glu Arg Arg Val Trp Leu Glu Glu
        595                 600                 605             
Lys Glu Lys Val Ile Glu Tyr Gln Lys Gln Leu Gln Leu Ser Tyr Val
    610                 615                 620                 
Glu Met Tyr Gln Arg Asn Gln Gln Leu Glu Arg Arg Leu Arg Glu Arg
625                 630                 635                 640 
Gly Ala Ala Gly Gly Ala Ser Thr Pro Thr Pro Gln His Gly Glu Glu
                645                 650                 655     
Lys Lys Ala Trp Thr Pro Ser Arg Leu Glu Arg Ile Glu Ser Thr Glu
            660                 665                 670         
Ile
    


<210> 8116
<211> 627
<212> PRT
<213> Homo sapiens

<400> 8116
Met Ala Lys Leu Glu Thr Leu Pro Val Arg Ala Asp Pro Gly Arg Asp
 1               5                  10                  15      
Pro Leu Leu Ala Phe Ala Pro Arg Pro Ser Glu Leu Gly Pro Pro Asp
            20                  25                  30          
Pro Arg Leu Ala Met Gly Ser Val Gly Ser Gly Val Ala His Ala Gln
        35                  40                  45              
Glu Phe Ala Met Lys Ser Val Gly Thr Arg Thr Gly Gly Gly Gly Ser
    50                  55                  60                  
Gln Gly Ser Phe Pro Gly Pro Arg Gly Ser Gly Ser Gly Ala Ser Arg
65                  70                  75                  80  
Glu Arg Pro Gly Arg Tyr Pro Ser Glu Asp Lys Gly Leu Ala Asn Ser
                85                  90                  95      
Leu Tyr Leu Asn Gly Glu Leu Arg Gly Ser Asp His Thr Asp Val Cys
            100                 105                 110         
Gly Asn Val Val Gly Ser Ser Gly Gly Ser Ser Ser Ser Gly Gly Ser
        115                 120                 125             
Asp Lys Ala Pro Pro Gln Tyr Arg Glu Pro Ser His Pro Pro Lys Leu
    130                 135                 140                 
Leu Ala Thr Ser Gly Lys Leu Asp Gln Cys Ser Glu Pro Leu Val Arg
145                 150                 155                 160 
Pro Ser Ala Phe Lys Pro Val Val Pro Lys Asn Phe His Ser Met Gln
                165                 170                 175     
Asn Leu Cys Pro Pro Gln Thr Asn Gly Thr Pro Glu Gly Arg Gln Gly
            180                 185                 190         
Pro Gly Gly Leu Lys Gly Gly Leu Asp Lys Ser Arg Thr Met Thr Pro
        195                 200                 205             
Ala Gly Gly Ser Gly Ser Gly Leu Ser Asp Ser Gly Arg Asn Ser Leu
    210                 215                 220                 
Thr Ser Leu Pro Thr Tyr Ser Ser Ser Tyr Ser Gln His Leu Ala Pro
225                 230                 235                 240 
Leu Ser Ala Ser Thr Ser His Ile Asn Arg Ile Gly Thr Ala Ser Tyr
                245                 250                 255     
Gly Ser Gly Ser Gly Gly Ser Ser Gly Gly Gly Ser Gly Tyr Gln Asp
            260                 265                 270         
Leu Gly Thr Ser Asp Ser Gly Arg Ala Ser Ser Lys Ser Gly Ser Ser
        275                 280                 285             
Ser Ser Met Gly Arg Pro Gly His Leu Gly Ser Gly Glu Gly Gly Gly
    290                 295                 300                 
Gly Gly Leu Pro Phe Ala Ala Cys Ser Pro Pro Ser Pro Ser Ala Leu
305                 310                 315                 320 
Ile Gln Glu Leu Glu Glu Arg Leu Trp Glu Lys Glu Gln Glu Val Ala
                325                 330                 335     
Ala Leu Arg Arg Ser Leu Glu Gln Ser Glu Ala Ala Val Ala Gln Gln
            340                 345                 350         
Asp Lys Lys Gln Leu Gln Glu Glu Ala Ala Arg Leu Met Arg Gln Arg
        355                 360                 365             
Glu Glu Leu Glu Asp Lys Val Ala Ala Cys Gln Lys Glu Gln Ala Asp
    370                 375                 380                 
Phe Leu Pro Arg Ile Glu Glu Thr Lys Trp Glu Val Cys Gln Lys Ala
385                 390                 395                 400 
Gly Glu Ile Ser Leu Leu Lys Gln Gln Leu Lys Asp Ser Gln Ala Asp
                405                 410                 415     
Val Ser Gln Lys Leu Ser Glu Ile Val Gly Leu Arg Ser Gln Leu Arg
            420                 425                 430         
Glu Gly Arg Ala Ser Leu Arg Glu Lys Glu Glu Gln Leu Leu Ser Leu
        435                 440                 445             
Arg Asp Ser Phe Ser Ser Lys Gln Ala Ser Leu Glu Leu Gly Glu Gly
    450                 455                 460                 
Glu Leu Pro Ala Ala Cys Leu Lys Pro Ala Leu Thr Pro Val Asp Pro
465                 470                 475                 480 
Ala Glu Pro Gln Asp Ala Leu Ala Thr Cys Glu Ser Asp Glu Ala Lys
                485                 490                 495     
Met Arg Arg Gln Ala Gly Val Ala Ala Ala Ala Ser Leu Val Tyr Val
            500                 505                 510         
Asp Gly Glu Ala Glu Ala Gly Gly Glu Ser Gly Thr Arg Ala Leu Arg
        515                 520                 525             
Arg Glu Val Gly Arg Leu Gln Ala Glu Leu Ala Ala Glu Arg Arg Ala
    530                 535                 540                 
Arg Glu Arg Gln Gly Ala Ser Phe Ala Glu Glu Arg Arg Val Trp Leu
545                 550                 555                 560 
Glu Glu Lys Glu Lys Val Ile Glu Tyr Gln Lys Gln Leu Gln Leu Ser
                565                 570                 575     
Tyr Val Glu Met Tyr Gln Arg Asn Gln Gln Leu Glu Arg Arg Leu Arg
            580                 585                 590         
Glu Arg Gly Ala Ala Gly Gly Ala Ser Thr Pro Thr Pro Gln His Gly
        595                 600                 605             
Glu Glu Lys Lys Ala Trp Thr Pro Ser Arg Leu Glu Arg Ile Glu Ser
    610                 615                 620                 
Thr Glu Ile
625         


<210> 8117
<211> 1967
<212> PRT
<213> Homo sapiens

<400> 8117
Leu Glu Phe Lys Ile Ser Asp Glu Glu Ala Asp Asp Ala Asp Ala Ala
 1               5                  10                  15      
Gly Arg Asp Ser Pro Ser Asn Thr Ser Gln Ser Glu Gln Gln Glu Ser
            20                  25                  30          
Val Asp Ala Glu Gly Pro Val Val Glu Lys Ile Met Ser Ser Arg Ser
        35                  40                  45              
Val Lys Lys Gln Lys Glu Ser Gly Glu Glu Val Glu Ile Glu Glu Phe
    50                  55                  60                  
Tyr Val Lys Tyr Lys Asn Phe Ser Tyr Leu His Cys Gln Trp Ala Ser
65                  70                  75                  80  
Ile Glu Asp Leu Glu Lys Asp Lys Arg Ile Gln Gln Lys Ile Lys Arg
                85                  90                  95      
Phe Lys Ala Lys Gln Gly Gln Asn Lys Phe Leu Ser Glu Ile Glu Asp
            100                 105                 110         
Glu Leu Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile Met Asp Phe
        115                 120                 125             
Ala Arg Ser Thr Asp Asp Arg Gly Glu Pro Val Thr His Tyr Leu Val
    130                 135                 140                 
Lys Trp Cys Ser Leu Pro Tyr Glu Asp Ser Thr Trp Glu Arg Arg Gln
145                 150                 155                 160 
Asp Ile Asp Gln Ala Lys Ile Glu Glu Phe Glu Lys Leu Met Ser Arg
                165                 170                 175     
Glu Pro Glu Thr Glu Arg Val Glu Arg Pro Pro Ala Asp Asp Trp Lys
            180                 185                 190         
Lys Ser Glu Ser Ser Arg Glu Tyr Lys Asn Asn Asn Lys Leu Arg Glu
        195                 200                 205             
Tyr Gln Leu Glu Gly Val Asn Trp Leu Leu Phe Asn Trp Tyr Asn Met
    210                 215                 220                 
Arg Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln
225                 230                 235                 240 
Ser Ile Thr Phe Leu Tyr Glu Ile Tyr Leu Lys Gly Ile His Gly Pro
                245                 250                 255     
Phe Leu Val Ile Ala Pro Leu Ser Thr Ile Pro Asn Trp Glu Arg Glu
            260                 265                 270         
Phe Arg Thr Trp Thr Glu Leu Asn Val Val Val Tyr His Gly Ser Gln
        275                 280                 285             
Ala Ser Arg Arg Thr Ile Gln Leu Tyr Glu Met Tyr Phe Lys Asp Pro
    290                 295                 300                 
Gln Gly Arg Val Ile Lys Gly Ser Tyr Lys Phe His Ala Ile Ile Thr
305                 310                 315                 320 
Thr Phe Glu Met Ile Leu Thr Asp Cys Pro Glu Leu Arg Asn Ile Pro
                325                 330                 335     
Trp Arg Cys Val Val Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn
            340                 345                 350         
Cys Lys Leu Leu Glu Gly Leu Lys Met Met Asp Leu Glu His Lys Val
        355                 360                 365             
Leu Leu Thr Gly Thr Pro Leu Gln Asn Thr Val Glu Glu Leu Phe Ser
    370                 375                 380                 
Leu Leu His Phe Leu Glu Pro Ser Arg Phe Pro Ser Glu Thr Thr Phe
385                 390                 395                 400 
Met Gln Glu Phe Gly Asp Leu Lys Thr Glu Glu Gln Val Gln Lys Leu
                405                 410                 415     
Gln Ala Ile Leu Lys Pro Met Met Leu Arg Arg Leu Lys Glu Asp Val
            420                 425                 430         
Glu Lys Asn Leu Ala Pro Lys Glu Glu Thr Ile Ile Glu Val Glu Leu
        435                 440                 445             
Thr Asn Ile Gln Lys Lys Tyr Tyr Arg Ala Ile Leu Glu Lys Asn Phe
    450                 455                 460                 
Thr Phe Leu Ser Lys Gly Gly Gly Gln Ala Asn Val Pro Asn Leu Leu
465                 470                 475                 480 
Asn Thr Met Met Glu Leu Arg Lys Cys Cys Asn His Pro Tyr Leu Ile
                485                 490                 495     
Asn Gly Ala Glu Glu Lys Ile Leu Glu Glu Phe Lys Glu Thr His Asn
            500                 505                 510         
Ala Glu Ser Pro Asp Phe Gln Leu Gln Ala Met Ile Gln Ala Ala Gly
        515                 520                 525             
Lys Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Leu Lys Ala Gly Gly
    530                 535                 540                 
His Arg Val Leu Ile Phe Ser Gln Met Val Arg Cys Leu Asp Ile Leu
545                 550                 555                 560 
Glu Asp Tyr Leu Ile Gln Arg Arg Tyr Pro Tyr Glu Arg Ile Asp Gly
                565                 570                 575     
Arg Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp Arg Phe Ser Lys
            580                 585                 590         
Pro Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Thr Arg Ala Gly Gly
        595                 600                 605             
Leu Gly Ile Asn Leu Thr Ala Ala Asp Thr Cys Ile Ile Phe Asp Ser
    610                 615                 620                 
Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala Arg Cys His Arg
625                 630                 635                 640 
Ile Gly Gln Ser Lys Ser Val Lys Ile Tyr Arg Leu Ile Thr Arg Asn
                645                 650                 655     
Ser Tyr Glu Arg Glu Met Phe Asp Lys Ala Ser Leu Lys Leu Gly Leu
            660                 665                 670         
Asp Lys Ala Val Leu Gln Ser Met Ser Gly Arg Glu Asn Ala Thr Asn
        675                 680                 685             
Gly Val Gln Gln Leu Ser Lys Lys Glu Ile Glu Asp Leu Leu Arg Lys
    690                 695                 700                 
Gly Ala Tyr Gly Ala Leu Met Asp Glu Glu Asp Glu Gly Ser Lys Phe
705                 710                 715                 720 
Cys Glu Glu Asp Ile Asp Gln Ile Leu Leu Arg Arg Thr His Thr Ile
                725                 730                 735     
Thr Ile Glu Ser Glu Gly Lys Gly Ser Thr Phe Ala Lys Ala Ser Phe
            740                 745                 750         
Val Ala Ser Gly Asn Arg Thr Asp Ile Ser Leu Asp Asp Pro Asn Phe
        755                 760                 765             
Trp Gln Lys Trp Ala Lys Lys Ala Glu Leu Asp Ile Asp Ala Leu Asn
    770                 775                 780                 
Gly Arg Asn Asn Leu Val Ile Asp Thr Pro Arg Val Arg Lys Gln Thr
785                 790                 795                 800 
Arg Leu Tyr Ser Ala Val Lys Glu Asp Glu Leu Met Glu Phe Ser Asp
                805                 810                 815     
Leu Glu Ser Asp Ser Glu Glu Lys Pro Cys Ala Lys Pro Arg Arg Pro
            820                 825                 830         
Gln Asp Lys Ser Gln Gly Tyr Ala Arg Ser Glu Cys Phe Arg Val Glu
        835                 840                 845             
Lys Asn Leu Leu Val Tyr Gly Trp Gly Arg Trp Thr Asp Ile Leu Ser
    850                 855                 860                 
His Gly Arg Tyr Lys Arg Gln Leu Thr Glu Gln Asp Val Glu Thr Ile
865                 870                 875                 880 
Cys Arg Thr Ile Leu Val Tyr Cys Leu Asn His Tyr Lys Gly Asp Glu
                885                 890                 895     
Asn Ile Lys Ser Phe Ile Trp Asp Leu Ile Thr Pro Thr Ala Asp Gly
            900                 905                 910         
Gln Thr Arg Ala Leu Val Asn His Ser Gly Leu Ser Ala Pro Val Pro
        915                 920                 925             
Arg Gly Arg Lys Gly Lys Lys Val Lys Ala Gln Ser Thr Gln Pro Val
    930                 935                 940                 
Val Gln Asp Ala Asp Trp Leu Ala Ser Cys Asn Pro Asp Ala Leu Phe
945                 950                 955                 960 
Gln Glu Asp Ser Tyr Lys Lys His Leu Lys His His Cys Asn Lys Val
                965                 970                 975     
Leu Leu Arg Val Arg Met Leu Tyr Tyr Leu Arg Gln Glu Val Ile Gly
            980                 985                 990         
Asp Gln Ala Asp Lys Ile Leu Glu Gly Ala Asp Ser Ser Glu Ala Asp
        995                 1000                1005            
Val Trp Ile Pro Glu Pro Phe His Ala Glu Val Pro Ala Asp Trp Trp
    1010                1015                1020                
Asp Lys Glu Ala Asp Lys Ser Leu Leu Ile Gly Val Phe Lys His Gly
1025                1030                1035                1040
Tyr Glu Lys Tyr Asn Ser Met Arg Ala Asp Pro Ala Leu Cys Phe Leu
                1045                1050                1055    
Glu Arg Val Gly Met Pro Asp Ala Lys Ala Ile Ala Ala Glu Gln Arg
            1060                1065                1070        
Gly Thr Asp Met Leu Ala Asp Gly Gly Asp Gly Gly Glu Phe Asp Arg
        1075                1080                1085            
Glu Asp Glu Asp Pro Glu Tyr Lys Pro Thr Arg Thr Pro Phe Lys Asp
    1090                1095                1100                
Glu Ile Asp Glu Phe Ala Asn Ser Pro Ser Glu Asp Lys Glu Glu Ser
1105                1110                1115                1120
Met Glu Ile His Ala Thr Gly Lys His Ser Glu Ser Asn Ala Glu Leu
                1125                1130                1135    
Gly Gln Leu Tyr Trp Pro Asn Thr Ser Thr Leu Thr Thr Arg Leu Arg
            1140                1145                1150        
Arg Leu Ile Thr Ala Tyr Gln Arg Ser Tyr Lys Arg Gln Gln Met Arg
        1155                1160                1165            
Gln Glu Ala Leu Met Lys Thr Asp Arg Arg Arg Arg Arg Pro Arg Glu
    1170                1175                1180                
Glu Val Arg Ala Leu Glu Ala Glu Arg Glu Ala Ile Ile Ser Glu Lys
1185                1190                1195                1200
Arg Gln Lys Trp Thr Arg Arg Glu Glu Ala Asp Phe Tyr Arg Val Val
                1205                1210                1215    
Ser Thr Phe Gly Val Ile Phe Asp Pro Val Lys Gln Gln Phe Asp Trp
            1220                1225                1230        
Asn Gln Phe Arg Ala Phe Ala Arg Leu Asp Lys Lys Ser Asp Glu Ser
        1235                1240                1245            
Leu Glu Lys Tyr Phe Ser Cys Phe Val Ala Met Cys Arg Arg Val Cys
    1250                1255                1260                
Arg Met Pro Val Lys Pro Asp Asp Glu Pro Pro Asp Leu Ser Ser Ile
1265                1270                1275                1280
Ile Glu Pro Ile Thr Glu Glu Arg Ala Ser Arg Thr Leu Tyr Arg Ile
                1285                1290                1295    
Glu Leu Leu Arg Lys Ile Arg Glu Gln Val Leu His His Pro Gln Leu
            1300                1305                1310        
Gly Glu Arg Leu Lys Leu Cys Gln Pro Ser Leu Asp Leu Pro Glu Trp
        1315                1320                1325            
Trp Glu Cys Gly Arg His Asp Arg Asp Leu Leu Val Gly Ala Ala Lys
    1330                1335                1340                
His Gly Val Ser Arg Thr Asp Tyr His Ile Leu Asn Asp Pro Glu Leu
1345                1350                1355                1360
Ser Phe Leu Asp Ala His Lys Asn Phe Ala Gln Asn Arg Gly Ala Gly
                1365                1370                1375    
Asn Thr Ser Ser Leu Asn Pro Leu Ala Val Gly Phe Val Gln Thr Pro
            1380                1385                1390        
Pro Val Ile Ser Ser Ala His Ile Gln Asp Glu Arg Val Leu Glu Gln
        1395                1400                1405            
Ala Glu Gly Lys Val Glu Glu Pro Glu Asn Pro Ala Ala Lys Glu Lys
    1410                1415                1420                
Cys Glu Gly Lys Glu Glu Glu Glu Glu Thr Asp Gly Ser Gly Lys Glu
1425                1430                1435                1440
Ser Lys Gln Glu Cys Glu Ala Glu Ala Ser Ser Val Lys Asn Glu Leu
                1445                1450                1455    
Lys Gly Val Glu Val Gly Ala Asp Thr Gly Ser Lys Ser Ile Ser Glu
            1460                1465                1470        
Lys Gly Ser Glu Glu Asp Glu Glu Glu Lys Leu Glu Asp Asp Asp Lys
        1475                1480                1485            
Ser Glu Glu Ser Ser Gln Pro Glu Ala Gly Ala Val Ser Arg Gly Lys
    1490                1495                1500                
Asn Phe Asp Glu Glu Ser Asn Ala Ser Met Ser Thr Ala Arg Asp Glu
1505                1510                1515                1520
Thr Arg Asp Gly Phe Tyr Met Glu Asp Gly Asp Pro Ser Val Ala Gln
                1525                1530                1535    
Leu Leu His Glu Arg Thr Phe Ala Phe Ser Phe Trp Pro Lys Asp Arg
            1540                1545                1550        
Val Met Ile Asn Arg Leu Asp Asn Ile Cys Glu Ala Val Leu Lys Gly
        1555                1560                1565            
Lys Trp Pro Val Asn Arg Arg Gln Met Phe Asp Phe Gln Gly Leu Ile
    1570                1575                1580                
Pro Gly Tyr Thr Pro Thr Thr Val Asp Ser Pro Leu Gln Lys Arg Ser
1585                1590                1595                1600
Phe Ala Glu Leu Ser Met Val Gly Gln Ala Ser Ile Ser Gly Ser Glu
                1605                1610                1615    
Asp Ile Thr Thr Ser Pro Gln Leu Ser Lys Glu Asp Ala Leu Asn Leu
            1620                1625                1630        
Ser Val Pro Arg Gln Arg Arg Arg Arg Arg Arg Lys Ile Glu Ile Glu
        1635                1640                1645            
Ala Glu Arg Ala Ala Lys Arg Arg Asn Leu Met Glu Met Val Ala Gln
    1650                1655                1660                
Leu Arg Glu Ser Gln Val Val Ser Glu Asn Gly Gln Glu Lys Val Val
1665                1670                1675                1680
Asp Leu Ser Lys Ala Ser Arg Glu Ala Thr Ser Ser Thr Ser Asn Phe
                1685                1690                1695    
Ser Ser Leu Ser Ser Lys Phe Ile Leu Pro Asn Val Ser Thr Pro Val
            1700                1705                1710        
Ser Asp Ala Phe Lys Thr Gln Met Glu Leu Leu Gln Ala Gly Leu Ser
        1715                1720                1725            
Arg Thr Pro Thr Arg His Leu Leu Asn Gly Ser Leu Val Asp Gly Glu
    1730                1735                1740                
Pro Pro Met Lys Arg Arg Arg Gly Arg Arg Lys Asn Val Glu Gly Leu
1745                1750                1755                1760
Asp Leu Leu Phe Met Ser His Lys Arg Thr Ser Leu Ser Ala Glu Asp
                1765                1770                1775    
Ala Glu Val Thr Lys Ala Phe Glu Glu Asp Ile Glu Thr Pro Pro Thr
            1780                1785                1790        
Arg Asn Ile Pro Ser Pro Gly Gln Leu Asp Pro Asp Thr Arg Ile Pro
        1795                1800                1805            
Val Ile Asn Leu Glu Asp Gly Thr Arg Leu Val Gly Glu Asp Ala Pro
    1810                1815                1820                
Lys Asn Lys Asp Leu Val Glu Trp Leu Lys Leu His Pro Thr Tyr Thr
1825                1830                1835                1840
Val Asp Met Pro Ser Tyr Val Pro Lys Asn Ala Asp Val Leu Phe Ser
                1845                1850                1855    
Ser Phe Gln Lys Pro Lys Gln Lys Arg His Arg Cys Arg Asn Pro Asn
            1860                1865                1870        
Lys Leu Asp Ile Asn Thr Leu Thr Gly Glu Glu Arg Val Pro Val Val
        1875                1880                1885            
Asn Lys Arg Asn Gly Lys Lys Met Gly Gly Ala Met Ala Pro Pro Met
    1890                1895                1900                
Lys Asp Leu Pro Arg Trp Leu Glu Glu Asn Pro Glu Phe Ala Val Ala
1905                1910                1915                1920
Pro Asp Trp Thr Asp Ile Val Lys Gln Ser Gly Phe Val Pro Glu Ser
                1925                1930                1935    
Met Phe Asp Arg Leu Leu Thr Gly Pro Val Val Arg Gly Glu Gly Ala
            1940                1945                1950        
Ser Arg Arg Gly Arg Arg Pro Lys Ser Glu Ile Ala Arg Ala Ala
        1955                1960                1965        


<210> 8118
<211> 1837
<212> PRT
<213> Homo sapiens

<400> 8118
Met Gly Asp Ser Lys Val Lys Val Ala Val Arg Ile Arg Pro Met Asn
 1               5                  10                  15      
Arg Arg Glu Thr Asp Leu His Thr Lys Cys Val Val Asp Val Asp Ala
            20                  25                  30          
Asn Lys Val Ile Leu Asn Pro Val Asn Thr Asn Leu Ser Lys Gly Asp
        35                  40                  45              
Ala Arg Asn Val Glu Val Phe Leu Thr His Thr Tyr Val His Phe Gln
    50                  55                  60                  
Gln Val Phe Ala Tyr Asp His Cys Phe Trp Ser Met Asp Glu Ser Val
65                  70                  75                  80  
Lys Glu Lys Tyr Ala Gly Gln Asp Ile Val Phe Lys Cys Leu Gly Glu
                85                  90                  95      
Asn Ile Leu Gln Asn Ala Phe Asp Gly Tyr Asn Ala Cys Ile Phe Ala
            100                 105                 110         
Tyr Gly Gln Thr Gly Ser Gly Lys Ser Tyr Thr Met Met Gly Thr Ala
        115                 120                 125             
Asp Gln Pro Gly Leu Ile Pro Arg Leu Cys Ser Gly Leu Phe Glu Arg
    130                 135                 140                 
Thr Gln Lys Glu Glu Asn Glu Glu Gln Ser Phe Lys Val Glu Val Ser
145                 150                 155                 160 
Tyr Met Glu Ile Tyr Asn Glu Lys Val Arg Asp Leu Leu Asp Pro Lys
                165                 170                 175     
Gly Ser Arg Gln Thr Leu Lys Val Arg Glu His Ser Val Leu Gly Pro
            180                 185                 190         
Tyr Val Asp Gly Leu Ser Lys Leu Ala Val Thr Ser Tyr Lys Asp Ile
        195                 200                 205             
Glu Ser Leu Met Ser Glu Gly Asn Lys Ser Arg Thr Val Ala Ala Thr
    210                 215                 220                 
Asn Met Asn Glu Glu Ser Ser Arg Ser His Ala Val Phe Lys Ile Thr
225                 230                 235                 240 
Leu Thr His Thr Leu Tyr Asp Val Lys Ser Gly Thr Ser Gly Glu Lys
                245                 250                 255     
Val Gly Lys Leu Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Thr
            260                 265                 270         
Lys Thr Gly Ala Ala Gly Asp Arg Leu Lys Glu Gly Ser Asn Ile Asn
        275                 280                 285             
Lys Ser Leu Thr Thr Leu Gly Leu Val Ile Ser Ala Leu Ala Asp Gln
    290                 295                 300                 
Ser Ala Gly Lys Asn Lys Asn Lys Phe Val Pro Tyr Arg Asp Ser Val
305                 310                 315                 320 
Leu Thr Trp Leu Leu Lys Asp Ser Leu Gly Gly Asn Ser Lys Thr Ala
                325                 330                 335     
Met Val Ala Thr Val Ser Pro Ala Ala Asp Asn Tyr Asp Glu Thr Leu
            340                 345                 350         
Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys His Ile Val Asn His Ala
        355                 360                 365             
Val Val Asn Glu Asp Pro Asn Ala Arg Ile Ile Arg Asp Leu Arg Glu
    370                 375                 380                 
Glu Val Glu Lys Leu Arg Glu Gln Leu Thr Lys Ala Glu Ala Met Lys
385                 390                 395                 400 
Ser Pro Glu Leu Lys Asp Arg Leu Glu Glu Ser Glu Lys Leu Ile Gln
                405                 410                 415     
Glu Met Thr Val Thr Trp Glu Glu Lys Leu Arg Lys Thr Glu Glu Ile
            420                 425                 430         
Ala Gln Glu Arg Gln Lys Gln Leu Glu Ser Leu Gly Ile Ser Leu Gln
        435                 440                 445             
Ser Ser Gly Ile Lys Val Gly Asp Asp Lys Cys Phe Leu Val Asn Leu
    450                 455                 460                 
Asn Ala Asp Pro Ala Leu Asn Glu Leu Leu Val Tyr Tyr Leu Lys Glu
465                 470                 475                 480 
His Thr Leu Ile Gly Ser Ala Asn Ser Gln Asp Ile Gln Leu Cys Gly
                485                 490                 495     
Met Gly Ile Leu Pro Glu His Cys Ile Ile Asp Ile Thr Ser Glu Gly
            500                 505                 510         
Gln Val Met Leu Thr Pro Gln Lys Asn Thr Arg Thr Phe Val Asn Gly
        515                 520                 525             
Ser Ser Val Ser Ser Pro Ile Gln Leu His His Gly Asp Arg Ile Leu
    530                 535                 540                 
Trp Gly Asn Asn His Phe Phe Arg Leu Asn Leu Pro Lys Lys Lys Lys
545                 550                 555                 560 
Lys Ala Glu Arg Glu Asp Glu Asp Gln Asp Pro Ser Met Lys Asn Glu
                565                 570                 575     
Asn Ser Ser Glu Gln Leu Asp Val Asp Gly Asp Ser Ser Ser Glu Val
            580                 585                 590         
Ser Ser Glu Val Asn Phe Asn Tyr Glu Tyr Ala Gln Met Glu Val Thr
        595                 600                 605             
Met Lys Ala Leu Gly Ser Asn Asp Pro Met Gln Ser Ile Leu Asn Ser
    610                 615                 620                 
Leu Glu Gln Gln His Glu Glu Glu Lys Arg Ser Ala Leu Glu Arg Gln
625                 630                 635                 640 
Arg Leu Met Tyr Glu His Glu Leu Glu Gln Leu Arg Arg Arg Leu Ser
                645                 650                 655     
Pro Glu Lys Gln Asn Cys Arg Ser Met Asp Arg Phe Ser Phe His Ser
            660                 665                 670         
Pro Ser Ala Gln Gln Arg Leu Arg Gln Trp Ala Glu Glu Arg Glu Ala
        675                 680                 685             
Thr Leu Asn Asn Ser Leu Met Arg Leu Arg Glu Gln Ile Val Lys Ala
    690                 695                 700                 
Asn Leu Leu Val Arg Glu Ala Asn Tyr Ile Ala Glu Glu Leu Asp Lys
705                 710                 715                 720 
Arg Thr Glu Tyr Lys Val Thr Leu Gln Ile Pro Ala Ser Ser Leu Asp
                725                 730                 735     
Ala Asn Arg Lys Arg Gly Ser Leu Leu Ser Glu Pro Ala Ile Gln Val
            740                 745                 750         
Arg Arg Lys Gly Lys Gly Lys Gln Ile Trp Ser Leu Glu Lys Leu Asp
        755                 760                 765             
Asn Arg Leu Leu Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Cys
    770                 775                 780                 
Glu Glu Asp Asn Pro Val Ile Arg Ser Tyr Phe Lys Arg Ala Asp Pro
785                 790                 795                 800 
Phe Tyr Asp Glu Gln Glu Asn His Ser Leu Ile Gly Val Ala Asn Val
                805                 810                 815     
Phe Leu Glu Ser Leu Phe Tyr Asp Val Lys Leu Gln Tyr Ala Val Pro
            820                 825                 830         
Ile Ile Asn Gln Lys Gly Glu Val Ala Gly Arg Leu His Val Glu Val
        835                 840                 845             
Met Arg Leu Ser Gly Asp Val Gly Glu Arg Ile Ala Gly Gly Asp Glu
    850                 855                 860                 
Val Ala Glu Val Ser Phe Glu Lys Glu Thr Gln Glu Asn Lys Leu Val
865                 870                 875                 880 
Cys Met Val Lys Ile Leu Gln Ala Thr Gly Leu Pro Gln His Leu Ser
                885                 890                 895     
His Phe Val Phe Cys Lys Tyr Ser Phe Trp Asp Gln Gln Glu Pro Val
            900                 905                 910         
Ile Val Ala Pro Glu Val Asp Thr Ser Ser Ser Ser Val Ser Lys Glu
        915                 920                 925             
Pro His Cys Met Val Val Phe Asp His Cys Asn Glu Phe Ser Val Asn
    930                 935                 940                 
Ile Thr Glu Asp Phe Ile Glu His Leu Ser Glu Gly Ala Leu Ala Ile
945                 950                 955                 960 
Glu Val Tyr Gly His Lys Ile Asn Asp Pro Arg Lys Asn Pro Ala Leu
                965                 970                 975     
Trp Asp Leu Gly Ile Ile Gln Ala Lys Thr Arg Ser Leu Arg Asp Arg
            980                 985                 990         
Trp Ser Glu Val Thr Arg Lys Leu Glu Phe Trp Val Gln Ile Leu Glu
        995                 1000                1005            
Gln Asn Glu Asn Gly Glu Tyr Cys Pro Val Glu Val Ile Ser Ala Lys
    1010                1015                1020                
Asp Val Pro Thr Gly Gly Ile Phe Gln Leu Arg Gln Gly Gln Ser Arg
1025                1030                1035                1040
Arg Val Gln Val Glu Val Lys Ser Val Gln Glu Ser Gly Thr Leu Pro
                1045                1050                1055    
Leu Met Glu Glu Cys Ile Leu Ser Val Gly Ile Gly Cys Val Lys Val
            1060                1065                1070        
Arg Pro Leu Arg Ala Pro Arg Thr His Glu Thr Phe His Glu Glu Glu
        1075                1080                1085            
Glu Asp Met Asp Ser Tyr Gln Asp Arg Asp Leu Glu Arg Leu Arg Arg
    1090                1095                1100                
Lys Trp Leu Asn Ala Leu Thr Lys Arg Gln Glu Tyr Leu Asp Gln Gln
1105                1110                1115                1120
Leu Gln Lys Leu Val Ser Lys Arg Asp Lys Thr Glu Asp Asp Ala Asp
                1125                1130                1135    
Arg Glu Ala Gln Leu Leu Glu Met Arg Leu Thr Leu Thr Glu Glu Arg
            1140                1145                1150        
Asn Ala Val Met Val Pro Ser Ala Gly Ser Gly Ile Pro Gly Ala Pro
        1155                1160                1165            
Ala Glu Trp Thr Pro Val Pro Gly Met Glu Thr His Ile Pro Val Ile
    1170                1175                1180                
Phe Leu Asp Leu Asn Ala Asp Asp Phe Ser Ser Gln Asp Asn Leu Asp
1185                1190                1195                1200
Asp Pro Glu Ala Gly Gly Trp Asp Ala Thr Leu Thr Gly Glu Glu Glu
                1205                1210                1215    
Glu Glu Phe Phe Glu Leu Gln Ile Val Lys Gln His Asp Gly Glu Val
            1220                1225                1230        
Lys Ala Glu Ala Ser Trp Asp Ser Ala Val His Gly Cys Pro Gln Leu
        1235                1240                1245            
Ser Arg Gly Thr Pro Val Asp Glu Arg Leu Phe Leu Ile Val Arg Val
    1250                1255                1260                
Thr Val Gln Leu Ser His Pro Ala Asp Met Gln Leu Val Leu Arg Lys
1265                1270                1275                1280
Arg Ile Cys Val Asn Val His Gly Arg Gln Gly Phe Ala Gln Ser Leu
                1285                1290                1295    
Leu Lys Lys Met Ser His Arg Ser Ser Ile Pro Gly Cys Gly Val Thr
            1300                1305                1310        
Phe Glu Ile Val Ser Asn Ile Pro Glu Asp Ala Gln Gly Val Glu Glu
        1315                1320                1325            
Arg Glu Ala Leu Ala Arg Met Ala Ala Asn Val Glu Asn Pro Ala Ser
    1330                1335                1340                
Ala Asp Ser Glu Ala Tyr Ile Glu Lys Tyr Leu Arg Ser Val Leu Ala
1345                1350                1355                1360
Val Glu Asn Leu Leu Thr Leu Asp Arg Leu Arg Gln Glu Val Ala Val
                1365                1370                1375    
Lys Glu Gln Leu Thr Gly Lys Gly Lys Leu Ser Arg Arg Ser Ile Ser
            1380                1385                1390        
Ser Pro Asn Val Asn Arg Leu Ser Gly Ser Arg Gln Asp Leu Ile Pro
        1395                1400                1405            
Ser Tyr Ser Leu Gly Ser Asn Lys Gly Arg Trp Glu Ser Gln Gln Asp
    1410                1415                1420                
Val Ser Gln Thr Thr Val Ser Arg Gly Ile Ala Pro Ala Pro Ala Leu
1425                1430                1435                1440
Ser Val Ser Pro Gln Asn Asn His Ser Pro Asp Pro Gly Leu Ser Asn
                1445                1450                1455    
Leu Ala Ala Ser Tyr Leu Asn Pro Val Lys Ser Phe Val Pro Gln Met
            1460                1465                1470        
Pro Lys Leu Leu Lys Ser Leu Phe Pro Val Arg Asp Glu Lys Arg Gly
        1475                1480                1485            
Lys Arg Pro Ser Pro Leu Ala His Gln Pro Val Pro Arg Ile Met Val
    1490                1495                1500                
Gln Ser Ala Ser Pro Asp Ile Arg Val Thr Arg Met Glu Glu Ala Gln
1505                1510                1515                1520
Pro Glu Met Gly Pro Asp Val Leu Val Gln Thr Met Gly Ala Pro Ala
                1525                1530                1535    
Leu Lys Ile Cys Asp Lys Pro Ala Lys Val Pro Ser Pro Pro Pro Val
            1540                1545                1550        
Ile Ala Val Thr Ala Val Thr Pro Ala Pro Glu Ala Gln Asp Gly Pro
        1555                1560                1565            
Pro Ser Pro Leu Ser Glu Ala Ser Ser Gly Tyr Phe Ser His Ser Val
    1570                1575                1580                
Ser Thr Ala Thr Leu Ser Asp Ala Leu Gly Pro Gly Leu Asp Ala Ala
1585                1590                1595                1600
Ala Pro Pro Gly Ser Met Pro Thr Ala Pro Glu Ala Glu Pro Glu Ala
                1605                1610                1615    
Pro Ile Ser His Pro Pro Pro Pro Thr Ala Val Pro Ala Glu Glu Pro
            1620                1625                1630        
Pro Gly Pro Gln Gln Leu Val Ser Pro Gly Arg Glu Arg Pro Asp Leu
        1635                1640                1645            
Glu Ala Pro Ala Pro Gly Ser Pro Phe Arg Val Arg Arg Val Arg Ala
    1650                1655                1660                
Ser Glu Leu Arg Ser Phe Ser Arg Met Leu Ala Gly Asp Pro Gly Cys
1665                1670                1675                1680
Ser Pro Gly Ala Glu Gly Asn Ala Pro Ala Pro Gly Ala Gly Gly Gln
                1685                1690                1695    
Ala Leu Ala Ser Asp Ser Glu Glu Ala Asp Glu Val Pro Glu Trp Leu
            1700                1705                1710        
Arg Glu Gly Glu Phe Val Thr Val Gly Ala His Lys Thr Gly Val Val
        1715                1720                1725            
Arg Tyr Val Gly Pro Ala Asp Phe Gln Glu Gly Thr Trp Val Gly Val
    1730                1735                1740                
Glu Leu Asp Leu Pro Ser Gly Lys Asn Asp Gly Ser Ile Gly Gly Lys
1745                1750                1755                1760
Gln Tyr Phe Arg Cys Asn Pro Gly Tyr Gly Leu Leu Val Arg Pro Ser
                1765                1770                1775    
Arg Val Arg Arg Ala Thr Gly Pro Val Arg Arg Arg Ser Thr Gly Leu
            1780                1785                1790        
Arg Leu Gly Ala Pro Glu Ala Arg Arg Ser Ala Thr Leu Ser Gly Ser
        1795                1800                1805            
Ala Thr Asn Leu Ala Ser Leu Thr Ala Ala Leu Ala Lys Ala Asp Arg
    1810                1815                1820                
Ser His Lys Asn Pro Glu Asn Arg Lys Ser Trp Ala Ser
1825                1830                1835        


<210> 8119
<211> 3997
<212> PRT
<213> Homo sapiens

<400> 8119
Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg
 1               5                  10                  15      
Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly
            20                  25                  30          
Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu
        35                  40                  45              
Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu
    50                  55                  60                  
Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val
65                  70                  75                  80  
Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile
                85                  90                  95      
Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr
            100                 105                 110         
Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala
        115                 120                 125             
Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile
    130                 135                 140                 
Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu
145                 150                 155                 160 
Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala
                165                 170                 175     
Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile
            180                 185                 190         
Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys
        195                 200                 205             
Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr
    210                 215                 220                 
Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe
225                 230                 235                 240 
Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His
                245                 250                 255     
Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro
            260                 265                 270         
Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu
        275                 280                 285             
Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn
    290                 295                 300                 
Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile
305                 310                 315                 320 
Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln
                325                 330                 335     
Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe
            340                 345                 350         
Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly
        355                 360                 365             
Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys
    370                 375                 380                 
Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr
385                 390                 395                 400 
Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln
                405                 410                 415     
Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr
            420                 425                 430         
Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly
        435                 440                 445             
Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys
    450                 455                 460                 
Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe
465                 470                 475                 480 
Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn
                485                 490                 495     
Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu
            500                 505                 510         
Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala
        515                 520                 525             
Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Val
    530                 535                 540                 
Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser
545                 550                 555                 560 
Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser
                565                 570                 575     
Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His
            580                 585                 590         
Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro
        595                 600                 605             
Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asn Glu Asn Glu Thr Ile Leu
    610                 615                 620                 
Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His
625                 630                 635                 640 
Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu
                645                 650                 655     
Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn
            660                 665                 670         
Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu
        675                 680                 685             
Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val
    690                 695                 700                 
Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln
705                 710                 715                 720 
Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys
                725                 730                 735     
Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser
            740                 745                 750         
Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr
        755                 760                 765             
Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile
    770                 775                 780                 
Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala
785                 790                 795                 800 
Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser
                805                 810                 815     
His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn
            820                 825                 830         
Glu Ile Phe Leu Ser Ile Gly Val Lys Ser Lys Asn Pro Leu Pro Thr
        835                 840                 845             
Leu Glu Gly Ser Ile Gln Asn Val Glu Leu Lys Tyr Cys Ser Thr Ser
    850                 855                 860                 
Leu Val Lys Cys Ala Ser Gly Thr Met Gly Ser Ile Lys Ile Cys Ala
865                 870                 875                 880 
Lys Ala Pro Val Asp Ser Gly Lys Glu Lys Leu Ile Pro Leu Leu Gln
                885                 890                 895     
Gly Pro Ser Asp Thr Lys Asp Leu His Ser Thr Lys Trp Leu Asn Glu
            900                 905                 910         
Ser Arg Lys Pro Glu Ser Leu Leu Ala Pro Asp Leu Met Ala Phe Thr
        915                 920                 925             
Ile Gln Val Pro Gln Tyr Ile Asp Tyr Cys His Asn Ser Gly Ala Val
    930                 935                 940                 
Leu Leu Cys Ser Ile Gln Gly Leu Ala Val Asn Ile Asp Pro Ile Leu
945                 950                 955                 960 
Tyr Thr Trp Leu Ile Tyr Gln Pro Gln Lys Arg Thr Ser Arg His Met
                965                 970                 975     
Gln Gln Gln Pro Val Val Ala Val Pro Leu Val Met Pro Val Cys Arg
            980                 985                 990         
Arg Lys Glu Asp Glu Val Ser Ile Gly Ser Ala Pro Leu Ala Lys Gln
        995                 1000                1005            
Gln Ser Tyr Gln Ala Ser Glu Tyr Ala Ser Ser Pro Val Lys Thr Lys
    1010                1015                1020                
Thr Val Thr Glu Ser Arg Pro Leu Ser Val Pro Val Lys Ala Met Leu
1025                1030                1035                1040
Asn Ile Ser Glu Ser Cys Arg Ser Pro Glu Glu Arg Met Lys Glu Phe
                1045                1050                1055    
Ile Gly Ile Val Trp Asn Ala Val Lys His Leu Thr Leu Gln Leu Glu
            1060                1065                1070        
Val Gln Ser Cys Cys Val Phe Ile Pro Asn Asp Ser Leu Pro Ser Pro
        1075                1080                1085            
Ser Thr Ile Val Ser Gly Asp Ile Pro Gly Thr Val Arg Ser Trp Tyr
    1090                1095                1100                
His Gly Gln Thr Ser Met Pro Gly Thr Leu Val Leu Cys Leu Pro Gln
1105                1110                1115                1120
Ile Lys Ile Ile Ser Ala Gly His Lys Tyr Met Glu Pro Leu Gln Glu
                1125                1130                1135    
Ile Pro Phe Val Ile Pro Arg Pro Ile Leu Glu Glu Gly Asp Ala Phe
            1140                1145                1150        
Pro Trp Thr Ile Ser Leu His Asn Phe Ser Ile Tyr Thr Leu Leu Gly
        1155                1160                1165            
Lys Gln Val Thr Leu Cys Leu Val Glu Pro Met Gly Cys Thr Ser Thr
    1170                1175                1180                
Leu Ala Val Thr Ser Gln Lys Leu Leu Ala Thr Gly Pro Asp Thr Arg
1185                1190                1195                1200
His Ser Phe Val Val Cys Leu His Val Asp Leu Glu Ser Leu Glu Ile
                1205                1210                1215    
Lys Cys Ser Asn Pro Gln Val Gln Leu Phe Tyr Glu Leu Thr Asp Ile
            1220                1225                1230        
Met Asn Lys Val Trp Asn Lys Ile Gln Lys Arg Gly Asn Leu Asn Leu
        1235                1240                1245            
Ser Pro Thr Ser Pro Glu Thr Met Ala Gly Pro Val Pro Thr Ser Pro
    1250                1255                1260                
Val Arg Ser Ser Ile Gly Thr Ala Pro Pro Asp Thr Ser Thr Cys Ser
1265                1270                1275                1280
Pro Ser Ala Asp Ile Gly Thr Thr Thr Glu Gly Asp Ser Ile Gln Ala
                1285                1290                1295    
Gly Glu Glu Ser Pro Phe Ser Asp Ser Val Thr Leu Glu Gln Thr Thr
            1300                1305                1310        
Ser Asn Ile Gly Gly Thr Ser Gly Arg Val Ser Leu Trp Met Gln Trp
        1315                1320                1325            
Val Leu Pro Lys Ile Thr Ile Lys Leu Phe Ala Pro Asp Pro Glu Asn
    1330                1335                1340                
Lys Gly Thr Glu Val Cys Met Val Ser Glu Leu Glu Asp Leu Ser Ala
1345                1350                1355                1360
Ser Ile Asp Val Gln Asp Val Tyr Thr Lys Val Lys Cys Lys Ile Glu
                1365                1370                1375    
Ser Phe Asn Ile Asp His Tyr Arg Ser Arg Pro Gly Glu Gly Trp Gln
            1380                1385                1390        
Ser Gly His Phe Glu Gly Val Phe Leu Gln Cys Lys Glu Lys Ser Val
        1395                1400                1405            
Thr Thr Thr Lys Leu Leu Asp Gly Thr His Gln Gln His Gly Phe Leu
    1410                1415                1420                
Ser Leu Thr Tyr Thr Lys Ala Val Thr Lys Asn Val Arg His Lys Leu
1425                1430                1435                1440
Thr Ser Arg Asn Glu Arg Arg Ser Phe His Lys Leu Ser Glu Gly Leu
                1445                1450                1455    
Met Asp Gly Ser Pro His Phe Leu His Glu Ile Leu Leu Ser Ala Gln
            1460                1465                1470        
Ala Phe Asp Ile Val Leu Tyr Phe Pro Leu Leu Asn Ala Ile Ala Ser
        1475                1480                1485            
Ile Phe Gln Ala Lys Leu Pro Lys Thr Gln Lys Glu Lys Arg Lys Ser
    1490                1495                1500                
Pro Gly Gln Pro Met Arg Thr His Thr Leu Thr Ser Arg Asn Leu Pro
1505                1510                1515                1520
Leu Ile Tyr Val Asn Thr Ser Val Ile Arg Ile Phe Ile Pro Lys Thr
                1525                1530                1535    
Glu Glu Met Gln Pro Thr Val Glu Ala Asn Gln Ala Ala Lys Glu Asp
            1540                1545                1550        
Thr Val Val Leu Lys Ile Gly Ser Val Ala Met Ala Pro Gln Ala Asp
        1555                1560                1565            
Asn Pro Leu Gly Arg Ser Val Leu Arg Lys Asp Ile Tyr Gln Arg Ala
    1570                1575                1580                
Leu Asn Leu Gly Ile Leu Arg Asp Pro Gly Ser Glu Ile Glu Asp Arg
1585                1590                1595                1600
Gln Tyr Gln Ile Asp Leu Gln Ser Ile Asn Ile Gly Thr Ala Gln Trp
                1605                1610                1615    
His Gln Leu Lys Pro Glu Lys Glu Ser Val Ser Gly Gly Val Val Thr
            1620                1625                1630        
Glu Thr Glu Arg Asn Ser Gln Asn Pro Ala Leu Glu Trp Asn Met Asp
        1635                1640                1645            
Ser Ser Ile Arg Arg His Gln Glu Arg Arg Ala Ile Leu Thr Pro Val
    1650                1655                1660                
Leu Thr Asp Phe Ser Val Arg Ile Thr Gly Ala Pro Ala Val Ile Phe
1665                1670                1675                1680
Thr Lys Val Val Ser Pro Glu Asn Leu His Thr Glu Glu Ile Leu Val
                1685                1690                1695    
Cys Gly His Ser Leu Glu Val Asn Ile Thr Thr Asn Leu Asp Phe Phe
            1700                1705                1710        
Leu Ser Val Ala Gln Val Gln Leu Leu His Gln Leu Ile Val Ala Asn
        1715                1720                1725            
Met Thr Gly Leu Glu Pro Ser Asn Lys Ala Ala Glu Ile Ser Lys Gln
    1730                1735                1740                
Glu Gln Lys Lys Val Asp Ile Phe Asp Gly Gly Met Ala Glu Thr Ser
1745                1750                1755                1760
Ser Arg Tyr Ser Gly Ala Gln Asp Ser Gly Ile Gly Ser Asp Ser Val
                1765                1770                1775    
Lys Ile Arg Ile Val Gln Ile Glu Gln His Ser Gly Ala Ser Gln His
            1780                1785                1790        
Arg Ile Ala Arg Pro Ser Arg Gln Ser Ser Ile Val Lys Asn Leu Asn
        1795                1800                1805            
Phe Ile Pro Phe Asp Ile Phe Ile Thr Ala Ser Arg Ile Ser Leu Met
    1810                1815                1820                
Thr Tyr Ser Cys Met Ala Leu Ser Lys Ser Lys Ser Gln Glu Gln Lys
1825                1830                1835                1840
Asn Asn Glu Lys Thr Asp Lys Ser Ser Leu Asn Leu Pro Glu Val Asp
                1845                1850                1855    
Ser Asp Val Ala Lys Pro Asn Gln Ala Cys Ile Ser Thr Val Thr Ala
            1860                1865                1870        
Glu Asp Leu Leu Arg Ser Ser Ile Ser Phe Pro Ser Gly Lys Lys Ile
        1875                1880                1885            
Gly Val Leu Ser Leu Glu Ser Leu His Ala Ser Thr Arg Ser Ser Ala
    1890                1895                1900                
Arg Gln Ala Leu Gly Ile Thr Ile Val Arg Gln Pro Gly Arg Arg Gly
1905                1910                1915                1920
Thr Gly Asp Leu Gln Leu Glu Pro Phe Leu Tyr Phe Ile Val Ser Gln
                1925                1930                1935    
Pro Ser Leu Leu Leu Ser Cys His His Arg Lys Gln Arg Val Glu Val
            1940                1945                1950        
Ser Ile Phe Asp Ala Val Leu Lys Gly Val Ala Ser Asp Tyr Lys Cys
        1955                1960                1965            
Ile Asp Pro Gly Lys Thr Leu Pro Glu Ala Leu Asp Tyr Cys Thr Val
    1970                1975                1980                
Trp Leu Gln Thr Val Pro Gly Glu Ile Asp Ser Lys Ser Gly Ile Pro
1985                1990                1995                2000
Pro Ser Phe Ile Thr Leu Gln Ile Lys Asp Phe Leu Asn Gly Pro Ala
                2005                2010                2015    
Asp Val Asn Leu Asp Ile Ser Lys Pro Leu Lys Ala Asn Leu Ser Phe
            2020                2025                2030        
Thr Lys Leu Asp Gln Ile Asn Leu Phe Leu Lys Lys Ile Lys Asn Ala
        2035                2040                2045            
His Ser Leu Ala His Ser Glu Glu Thr Ser Ala Met Ser Asn Thr Met
    2050                2055                2060                
Val Asn Lys Asp Asp Leu Pro Val Ser Lys Tyr Tyr Arg Gly Lys Leu
2065                2070                2075                2080
Ser Lys Pro Lys Ile His Gly Asp Gly Val Gln Lys Ile Ser Ala Gln
                2085                2090                2095    
Glu Asn Met Trp Arg Ala Val Ser Cys Phe Gln Lys Ile Ser Val Gln
            2100                2105                2110        
Thr Thr Gln Ile Val Ile Ser Met Glu Thr Val Pro His Thr Ser Lys
        2115                2120                2125            
Pro Cys Leu Leu Ala Ser Leu Ser Asn Leu Asn Gly Ser Leu Ser Val
    2130                2135                2140                
Lys Ala Thr Gln Lys Val Pro Gly Ile Ile Leu Gly Ser Ser Phe Leu
2145                2150                2155                2160
Leu Ser Ile Asn Asp Phe Leu Leu Lys Thr Ser Leu Lys Glu Arg Ser
                2165                2170                2175    
Arg Ile Leu Ile Gly Pro Cys Cys Ala Thr Ala Asn Leu Glu Ala Lys
            2180                2185                2190        
Trp Cys Lys His Ser Gly Asn Pro Gly Pro Glu Gln Ser Ile Pro Lys
        2195                2200                2205            
Ile Ser Ile Asp Leu Arg Gly Gly Leu Leu Gln Val Phe Trp Gly Gln
    2210                2215                2220                
Glu His Leu Asn Cys Leu Val Leu Leu His Glu Leu Leu Asn Gly Tyr
2225                2230                2235                2240
Leu Asn Glu Glu Gly Asn Phe Glu Val Gln Val Ser Glu Pro Val Pro
                2245                2250                2255    
Gln Met Ser Ser Pro Val Glu Lys Asn Gln Thr Phe Lys Ser Glu Gln
            2260                2265                2270        
Ser Ser Asp Asp Leu Arg Thr Gly Leu Phe Gln Tyr Val Gln Asp Ala
        2275                2280                2285            
Glu Ser Leu Lys Leu Pro Gly Val Tyr Glu Val Leu Phe Tyr Asn Glu
    2290                2295                2300                
Thr Glu Asp Cys Pro Gly Met Met Leu Trp Arg Tyr Pro Glu Pro Arg
2305                2310                2315                2320
Val Leu Thr Leu Val Arg Ile Thr Pro Val Pro Phe Asn Thr Thr Glu
                2325                2330                2335    
Asp Pro Asp Ile Ser Thr Ala Asp Leu Gly Asp Val Leu Gln Val Pro
            2340                2345                2350        
Cys Ser Leu Glu Tyr Trp Asp Glu Leu Gln Lys Val Phe Val Ala Phe
        2355                2360                2365            
Arg Glu Phe Asn Leu Ser Glu Ser Lys Val Cys Glu Leu Gln Leu Pro
    2370                2375                2380                
Asp Ile Asn Leu Val Asn Asp Gln Lys Lys Leu Val Ser Ser Asp Leu
2385                2390                2395                2400
Trp Arg Ile Val Leu Asn Ser Ser Gln Asn Gly Ala Asp Asp Gln Ser
                2405                2410                2415    
Ser Ala Ser Glu Ser Gly Ser Gln Ser Thr Cys Asp Pro Leu Val Thr
            2420                2425                2430        
Pro Thr Ala Leu Ala Ala Cys Thr Arg Val Asp Ser Cys Phe Thr Pro
        2435                2440                2445            
Trp Phe Val Pro Ser Leu Cys Val Ser Phe Gln Phe Ala His Leu Glu
    2450                2455                2460                
Phe His Leu Cys His His Leu Asp Gln Leu Gly Thr Ala Ala Pro Gln
2465                2470                2475                2480
Tyr Leu Gln Pro Phe Val Ser Asp Arg Asn Met Pro Ser Glu Leu Glu
                2485                2490                2495    
Tyr Met Ile Val Ser Phe Arg Glu Pro His Met Tyr Leu Arg Gln Trp
            2500                2505                2510        
Asn Asn Gly Ser Val Cys Gln Glu Ile Gln Phe Leu Ala Gln Ala Asp
        2515                2520                2525            
Cys Lys Leu Leu Glu Cys Arg Asn Val Thr Met Gln Ser Val Val Lys
    2530                2535                2540                
Pro Phe Ser Ile Phe Gly Gln Met Ala Val Ser Ser Asp Val Val Glu
2545                2550                2555                2560
Lys Leu Leu Asp Cys Thr Val Ile Val Asp Ser Val Phe Val Asn Leu
                2565                2570                2575    
Gly Gln His Val Val His Ser Leu Asn Thr Ala Ile Gln Ala Trp Gln
            2580                2585                2590        
Gln Asn Lys Cys Pro Glu Val Glu Glu Leu Val Phe Ser His Phe Val
        2595                2600                2605            
Ile Cys Asn Asp Thr Gln Glu Thr Leu Arg Phe Gly Gln Val Asp Thr
    2610                2615                2620                
Asp Glu Asn Ile Leu Leu Ala Ser Leu His Ser His Gln Tyr Ser Trp
2625                2630                2635                2640
Arg Ser His Lys Ser Pro Gln Leu Leu His Ile Cys Ile Glu Gly Trp
                2645                2650                2655    
Gly Asn Trp Arg Trp Ser Glu Pro Phe Ser Val Asp His Ala Gly Thr
            2660                2665                2670        
Phe Ile Arg Thr Ile Gln Tyr Arg Gly Arg Thr Ala Ser Leu Ile Ile
        2675                2680                2685            
Lys Val Gln Gln Leu Asn Gly Val Gln Lys Gln Ile Ile Ile Cys Gly
    2690                2695                2700                
Arg Gln Ile Ile Cys Ser Tyr Leu Ser Gln Ser Ile Glu Leu Lys Val
2705                2710                2715                2720
Val Gln His Tyr Ile Gly Gln Asp Gly Gln Ala Val Val Arg Glu His
                2725                2730                2735    
Phe Asp Cys Leu Thr Ala Lys Gln Lys Leu Pro Ser Tyr Ile Leu Glu
            2740                2745                2750        
Asn Asn Glu Leu Thr Glu Leu Cys Val Lys Ala Lys Gly Asp Glu Asp
        2755                2760                2765            
Trp Ser Arg Asp Val Cys Leu Glu Ser Lys Ala Pro Glu Tyr Ser Ile
    2770                2775                2780                
Val Ile Gln Val Pro Ser Ser Asn Ser Ser Ile Ile Tyr Val Trp Cys
2785                2790                2795                2800
Thr Val Leu Thr Leu Glu Pro Asn Ser Gln Val Gln Gln Arg Met Ile
                2805                2810                2815    
Val Phe Ser Pro Leu Phe Ile Met Arg Ser His Leu Pro Asp Pro Ile
            2820                2825                2830        
Ile Ile His Leu Glu Lys Arg Ser Leu Gly Leu Ser Glu Thr Gln Ile
        2835                2840                2845            
Ile Pro Gly Lys Gly Gln Glu Lys Pro Leu Gln Asn Ile Glu Pro Asp
    2850                2855                2860                
Leu Val His His Leu Thr Phe Gln Ala Arg Glu Glu Tyr Asp Pro Ser
2865                2870                2875                2880
Asp Cys Ala Val Pro Ile Ser Thr Ser Leu Ile Lys Gln Ile Ala Thr
                2885                2890                2895    
Lys Val His Pro Gly Gly Thr Val Asn Gln Ile Leu Asp Glu Phe Tyr
            2900                2905                2910        
Gly Pro Glu Lys Ser Leu Gln Pro Ile Trp Pro Tyr Asn Lys Lys Asp
        2915                2920                2925            
Ser Asp Arg Asn Glu Gln Leu Ser Gln Trp Asp Ser Pro Met Arg Val
    2930                2935                2940                
Lys Leu Ser Ile Trp Lys Pro Tyr Val Arg Thr Leu Leu Ile Glu Leu
2945                2950                2955                2960
Leu Pro Trp Ala Leu Leu Ile Asn Glu Ser Lys Trp Asp Leu Trp Leu
                2965                2970                2975    
Phe Glu Gly Glu Lys Ile Val Leu Gln Val Pro Ala Gly Lys Ile Ile
            2980                2985                2990        
Ile Pro Pro Asn Phe Gln Glu Ala Phe Gln Ile Gly Ile Tyr Trp Ala
        2995                3000                3005            
Asn Thr Asn Thr Val His Lys Ser Val Ala Ile Lys Leu Val His Asn
    3010                3015                3020                
Leu Thr Ser Pro Lys Trp Lys Asp Gly Gly Asn Gly Glu Val Val Thr
3025                3030                3035                3040
Leu Asp Glu Glu Ala Phe Val Asp Thr Glu Ile Arg Leu Gly Ala Phe
                3045                3050                3055    
Pro Gly His Gln Lys Leu Cys Gln Phe Cys Ile Ser Ser Met Val Gln
            3060                3065                3070        
Gln Gly Ile Gln Ile Ile Gln Ile Glu Asp Lys Thr Thr Ile Ile Asn
        3075                3080                3085            
Asn Thr Pro Tyr Gln Ile Phe Tyr Lys Pro Gln Leu Ser Val Cys Asn
    3090                3095                3100                
Pro His Ser Gly Lys Glu Tyr Phe Arg Val Pro Asp Ser Ala Thr Phe
3105                3110                3115                3120
Ser Ile Cys Pro Gly Gly Glu Gln Pro Ala Met Lys Ser Ser Ser Leu
                3125                3130                3135    
Pro Cys Trp Asp Leu Met Pro Asp Ile Ser Gln Ser Val Leu Asp Ala
            3140                3145                3150        
Ser Leu Leu Gln Lys Gln Ile Met Leu Gly Phe Ser Pro Ala Pro Gly
        3155                3160                3165            
Ala Asp Ser Ser Gln Cys Trp Ser Leu Pro Ala Ile Val Arg Pro Glu
    3170                3175                3180                
Phe Pro Arg Gln Ser Val Ala Val Pro Leu Gly Asn Phe Arg Glu Asn
3185                3190                3195                3200
Gly Phe Cys Thr Arg Ala Ile Val Leu Thr Tyr Gln Glu His Leu Gly
                3205                3210                3215    
Val Thr Tyr Leu Thr Leu Ser Glu Asp Pro Ser Pro Arg Val Ile Ile
            3220                3225                3230        
His Asn Arg Cys Pro Val Lys Met Leu Ile Lys Glu Asn Ile Lys Asp
        3235                3240                3245            
Ile Pro Lys Phe Glu Val Tyr Cys Lys Lys Ile Pro Ser Glu Cys Ser
    3250                3255                3260                
Ile His His Glu Leu Tyr His Gln Ile Ser Ser Tyr Pro Asp Cys Lys
3265                3270                3275                3280
Thr Lys Asp Leu Leu Pro Ser Leu Leu Leu Arg Val Glu Pro Leu Asp
                3285                3290                3295    
Glu Val Thr Thr Glu Trp Ser Asp Ala Ile Asp Ile Asn Ser Gln Gly
            3300                3305                3310        
Thr Gln Val Val Phe Leu Thr Gly Phe Gly Tyr Val Tyr Val Asp Val
        3315                3320                3325            
Val His Gln Cys Gly Thr Val Phe Ile Thr Val Ala Pro Glu Gly Lys
    3330                3335                3340                
Ala Gly Pro Ile Leu Thr Asn Thr Asn Arg Ala Pro Glu Lys Ile Val
3345                3350                3355                3360
Thr Phe Lys Met Phe Ile Thr Gln Leu Ser Leu Ala Val Phe Asp Asp
                3365                3370                3375    
Leu Thr His His Lys Ala Ser Ala Glu Leu Leu Arg Leu Thr Leu Asp
            3380                3385                3390        
Asn Ile Phe Leu Cys Val Ala Pro Gly Ala Gly Pro Leu Pro Gly Glu
        3395                3400                3405            
Glu Pro Val Ala Ala Leu Phe Glu Leu Tyr Cys Val Glu Ile Cys Cys
    3410                3415                3420                
Gly Asp Leu Gln Leu Asp Asn Gln Leu Tyr Asn Lys Ser Asn Phe His
3425                3430                3435                3440
Phe Ala Val Leu Val Cys Gln Gly Glu Lys Ala Glu Pro Ile Gln Cys
                3445                3450                3455    
Ser Lys Met Gln Ser Leu Leu Ile Ser Asn Lys Glu Leu Glu Glu Tyr
            3460                3465                3470        
Lys Glu Lys Cys Phe Ile Lys Leu Cys Ile Thr Leu Asn Glu Gly Lys
        3475                3480                3485            
Ser Ile Leu Cys Asp Ile Asn Glu Phe Ser Phe Glu Leu Lys Pro Ala
    3490                3495                3500                
Arg Leu Tyr Val Glu Asp Thr Phe Val Tyr Tyr Ile Lys Thr Leu Phe
3505                3510                3515                3520
Asp Thr Tyr Leu Pro Asn Ser Arg Leu Ala Gly His Ser Thr His Leu
                3525                3530                3535    
Ser Gly Gly Lys Gln Val Leu Pro Met Gln Val Thr Gln His Ala Arg
            3540                3545                3550        
Ala Leu Val Asn Pro Val Lys Leu Arg Lys Leu Val Ile Gln Pro Val
        3555                3560                3565            
Asn Leu Leu Val Ser Ile His Ala Ser Leu Lys Leu Tyr Ile Ala Ser
    3570                3575                3580                
Asp His Thr Pro Leu Ser Phe Ser Val Phe Glu Arg Gly Pro Ile Phe
3585                3590                3595                3600
Thr Thr Ala Arg Gln Leu Val His Ala Leu Ala Met His Tyr Ala Ala
                3605                3610                3615    
Gly Ala Leu Phe Arg Ala Gly Trp Val Val Gly Ser Leu Asp Ile Leu
            3620                3625                3630        
Gly Ser Pro Ala Ser Leu Val Arg Ser Ile Gly Asn Gly Val Ala Asp
        3635                3640                3645            
Phe Phe Arg Leu Pro Tyr Glu Gly Leu Thr Arg Gly Pro Gly Ala Phe
    3650                3655                3660                
Val Ser Gly Val Ser Arg Gly Thr Thr Ser Phe Val Lys His Ile Ser
3665                3670                3675                3680
Lys Gly Thr Leu Thr Ser Ile Thr Asn Leu Ala Thr Ser Leu Ala Arg
                3685                3690                3695    
Asn Met Asp Arg Leu Ser Leu Asp Glu Glu His Tyr Asn Arg Gln Glu
            3700                3705                3710        
Glu Trp Arg Arg Gln Leu Pro Glu Ser Leu Gly Glu Gly Leu Arg Gln
        3715                3720                3725            
Gly Leu Ser Arg Leu Gly Ile Ser Leu Leu Gly Ala Ile Ala Gly Ile
    3730                3735                3740                
Val Asp Gln Pro Met Gln Asn Phe Gln Lys Thr Ser Glu Ala Gln Ala
3745                3750                3755                3760
Ser Ala Gly His Lys Ala Lys Gly Val Ile Ser Gly Val Gly Lys Gly
                3765                3770                3775    
Ile Met Gly Val Phe Thr Lys Pro Ile Gly Gly Ala Ala Glu Leu Val
            3780                3785                3790        
Ser Gln Thr Gly Tyr Gly Ile Leu His Gly Ala Gly Leu Ser Gln Leu
        3795                3800                3805            
Pro Lys Gln Arg His Gln Pro Ser Asp Leu His Ala Asp Gln Ala Pro
    3810                3815                3820                
Asn Ser His Val Lys Tyr Val Trp Lys Met Leu Gln Ser Leu Gly Arg
3825                3830                3835                3840
Pro Glu Val His Met Ala Leu Asp Val Val Leu Val Arg Gly Ser Gly
                3845                3850                3855    
Gln Glu His Glu Gly Cys Leu Leu Leu Thr Ser Glu Val Leu Phe Val
            3860                3865                3870        
Val Ser Val Ser Glu Asp Thr Gln Gln Gln Ala Phe Pro Val Thr Glu
        3875                3880                3885            
Ile Asp Cys Ala Gln Asp Ser Lys Gln Asn Asn Leu Leu Thr Val Gln
    3890                3895                3900                
Leu Lys Gln Pro Arg Val Ala Cys Asp Val Glu Val Asp Gly Val Arg
3905                3910                3915                3920
Glu Arg Leu Ser Glu Gln Gln Tyr Asn Arg Leu Val Asp Tyr Ile Thr
                3925                3930                3935    
Lys Thr Ser Cys His Leu Ala Pro Ser Cys Ser Ser Met Gln Ile Pro
            3940                3945                3950        
Cys Pro Val Val Ala Ala Glu Pro Pro Pro Ser Thr Val Lys Thr Tyr
        3955                3960                3965            
His Tyr Leu Val Asp Pro His Phe Ala Gln Val Phe Leu Ser Lys Phe
    3970                3975                3980                
Thr Met Val Lys Asn Lys Ala Leu Arg Lys Gly Phe Pro
3985                3990                3995        


<210> 8120
<211> 4022
<212> PRT
<213> Homo sapiens

<400> 8120
Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg
 1               5                  10                  15      
Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly
            20                  25                  30          
Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu
        35                  40                  45              
Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu
    50                  55                  60                  
Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val
65                  70                  75                  80  
Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile
                85                  90                  95      
Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr
            100                 105                 110         
Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala
        115                 120                 125             
Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile
    130                 135                 140                 
Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu
145                 150                 155                 160 
Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala
                165                 170                 175     
Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile
            180                 185                 190         
Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys
        195                 200                 205             
Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr
    210                 215                 220                 
Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe
225                 230                 235                 240 
Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His
                245                 250                 255     
Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro
            260                 265                 270         
Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu
        275                 280                 285             
Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn
    290                 295                 300                 
Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile
305                 310                 315                 320 
Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln
                325                 330                 335     
Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe
            340                 345                 350         
Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly
        355                 360                 365             
Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys
    370                 375                 380                 
Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr
385                 390                 395                 400 
Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln
                405                 410                 415     
Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr
            420                 425                 430         
Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly
        435                 440                 445             
Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys
    450                 455                 460                 
Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe
465                 470                 475                 480 
Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn
                485                 490                 495     
Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu
            500                 505                 510         
Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala
        515                 520                 525             
Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Val
    530                 535                 540                 
Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser
545                 550                 555                 560 
Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser
                565                 570                 575     
Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His
            580                 585                 590         
Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro
        595                 600                 605             
Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asn Glu Asn Glu Thr Ile Leu
    610                 615                 620                 
Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His
625                 630                 635                 640 
Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu
                645                 650                 655     
Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn
            660                 665                 670         
Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu
        675                 680                 685             
Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val
    690                 695                 700                 
Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln
705                 710                 715                 720 
Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys
                725                 730                 735     
Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser
            740                 745                 750         
Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr
        755                 760                 765             
Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile
    770                 775                 780                 
Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala
785                 790                 795                 800 
Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser
                805                 810                 815     
His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn
            820                 825                 830         
Glu Ile Phe Leu Ser Ile Gly Val Lys Ser Lys Asn Pro Leu Pro Thr
        835                 840                 845             
Leu Glu Gly Ser Ile Gln Asn Val Glu Leu Lys Tyr Cys Ser Thr Ser
    850                 855                 860                 
Leu Val Lys Cys Ala Ser Gly Thr Met Gly Ser Ile Lys Ile Cys Ala
865                 870                 875                 880 
Lys Ala Pro Val Asp Ser Gly Lys Glu Lys Leu Ile Pro Leu Leu Gln
                885                 890                 895     
Gly Pro Ser Asp Thr Lys Asp Leu His Ser Thr Lys Trp Leu Asn Glu
            900                 905                 910         
Ser Arg Lys Pro Glu Ser Leu Leu Ala Pro Asp Leu Met Ala Phe Thr
        915                 920                 925             
Ile Gln Val Pro Gln Tyr Ile Asp Tyr Cys His Asn Ser Gly Ala Val
    930                 935                 940                 
Leu Leu Cys Ser Ile Gln Gly Leu Ala Val Asn Ile Asp Pro Ile Leu
945                 950                 955                 960 
Tyr Thr Trp Leu Ile Tyr Gln Pro Gln Lys Arg Thr Ser Arg His Met
                965                 970                 975     
Gln Gln Gln Pro Val Val Ala Val Pro Leu Val Met Pro Val Cys Arg
            980                 985                 990         
Arg Lys Glu Asp Glu Val Ser Ile Gly Ser Ala Pro Leu Ala Lys Gln
        995                 1000                1005            
Gln Ser Tyr Gln Ala Ser Glu Tyr Ala Ser Ser Pro Val Lys Thr Lys
    1010                1015                1020                
Thr Val Thr Glu Ser Arg Pro Leu Ser Val Pro Val Lys Ala Met Leu
1025                1030                1035                1040
Asn Ile Ser Glu Ser Cys Arg Ser Pro Glu Glu Arg Met Lys Glu Phe
                1045                1050                1055    
Ile Gly Ile Val Trp Asn Ala Val Lys His Leu Thr Leu Gln Leu Glu
            1060                1065                1070        
Val Gln Ser Cys Cys Val Phe Ile Pro Asn Asp Ser Leu Pro Ser Pro
        1075                1080                1085            
Ser Thr Ile Val Ser Gly Asp Ile Pro Gly Thr Val Arg Ser Trp Tyr
    1090                1095                1100                
His Gly Gln Thr Ser Met Pro Gly Thr Leu Val Leu Cys Leu Pro Gln
1105                1110                1115                1120
Ile Lys Ile Ile Ser Ala Gly His Lys Tyr Met Glu Pro Leu Gln Glu
                1125                1130                1135    
Ile Pro Phe Val Ile Pro Arg Pro Ile Leu Glu Glu Gly Asp Ala Phe
            1140                1145                1150        
Pro Trp Thr Ile Ser Leu His Asn Phe Ser Ile Tyr Thr Leu Leu Gly
        1155                1160                1165            
Lys Gln Val Thr Leu Cys Leu Val Glu Pro Met Gly Cys Thr Ser Thr
    1170                1175                1180                
Leu Ala Val Thr Ser Gln Lys Leu Leu Ala Thr Gly Pro Asp Thr Arg
1185                1190                1195                1200
His Ser Phe Val Val Cys Leu His Val Asp Leu Glu Ser Leu Glu Ile
                1205                1210                1215    
Lys Cys Ser Asn Pro Gln Val Gln Leu Phe Tyr Glu Leu Thr Asp Ile
            1220                1225                1230        
Met Asn Lys Val Trp Asn Lys Ile Gln Lys Arg Gly Asn Leu Asn Leu
        1235                1240                1245            
Ser Pro Thr Ser Pro Glu Thr Met Ala Gly Pro Val Pro Thr Ser Pro
    1250                1255                1260                
Val Arg Ser Ser Ile Gly Thr Ala Pro Pro Asp Thr Ser Thr Cys Ser
1265                1270                1275                1280
Pro Ser Ala Asp Ile Gly Thr Thr Thr Glu Gly Asp Ser Ile Gln Ala
                1285                1290                1295    
Gly Glu Glu Ser Pro Phe Ser Asp Ser Val Thr Leu Glu Gln Thr Thr
            1300                1305                1310        
Ser Asn Ile Gly Gly Thr Ser Gly Arg Val Ser Leu Trp Met Gln Trp
        1315                1320                1325            
Val Leu Pro Lys Ile Thr Ile Lys Leu Phe Ala Pro Asp Pro Glu Asn
    1330                1335                1340                
Lys Gly Thr Glu Val Cys Met Val Ser Glu Leu Glu Asp Leu Ser Ala
1345                1350                1355                1360
Ser Ile Asp Val Gln Asp Val Tyr Thr Lys Val Lys Cys Lys Ile Glu
                1365                1370                1375    
Ser Phe Asn Ile Asp His Tyr Arg Ser Ser His Gly Glu Glu Cys Trp
            1380                1385                1390        
Ser Leu Gly Gln Cys Gly Gly Val Ile Leu Ser Cys Thr Asp Lys Leu
        1395                1400                1405            
Asn Arg Arg Thr Leu Leu Val Arg Pro Ile Ser Lys Gln Asp Pro Phe
    1410                1415                1420                
Arg Asn Cys Ser Gly Phe Phe Pro Ser Thr Thr Thr Lys Leu Leu Asp
1425                1430                1435                1440
Gly Thr His Gln Gln His Gly Phe Leu Ser Leu Thr Tyr Thr Lys Ala
                1445                1450                1455    
Val Thr Lys Asn Val Arg His Lys Leu Thr Ser Arg Asn Glu Arg Arg
            1460                1465                1470        
Ser Phe His Lys Leu Ser Glu Gly Leu Met Asp Gly Ser Pro His Phe
        1475                1480                1485            
Leu His Glu Ile Leu Leu Ser Ala Gln Ala Phe Asp Ile Val Leu Tyr
    1490                1495                1500                
Phe Pro Leu Leu Asn Ala Ile Ala Ser Ile Phe Gln Ala Lys Leu Pro
1505                1510                1515                1520
Lys Thr Gln Lys Glu Lys Arg Lys Ser Pro Gly Gln Pro Met Arg Thr
                1525                1530                1535    
His Thr Leu Thr Ser Arg Asn Leu Pro Leu Ile Tyr Val Asn Thr Ser
            1540                1545                1550        
Val Ile Arg Ile Phe Ile Pro Lys Thr Glu Glu Met Gln Pro Thr Val
        1555                1560                1565            
Glu Ala Asn Gln Ala Ala Lys Glu Asp Thr Val Val Leu Lys Ile Gly
    1570                1575                1580                
Ser Val Ala Met Ala Pro Gln Ala Asp Asn Pro Leu Gly Arg Ser Val
1585                1590                1595                1600
Leu Arg Lys Asp Ile Tyr Gln Arg Ala Leu Asn Leu Gly Ile Leu Arg
                1605                1610                1615    
Asp Pro Gly Ser Glu Ile Glu Asp Arg Gln Tyr Gln Ile Asp Leu Gln
            1620                1625                1630        
Ser Ile Asn Ile Gly Thr Ala Gln Trp His Gln Leu Lys Pro Glu Lys
        1635                1640                1645            
Glu Ser Val Ser Gly Gly Val Val Thr Glu Thr Glu Arg Asn Ser Gln
    1650                1655                1660                
Asn Pro Ala Leu Glu Trp Asn Met Asp Ser Ser Ile Arg Arg His Gln
1665                1670                1675                1680
Glu Arg Arg Ala Ile Leu Thr Pro Val Leu Thr Asp Phe Ser Val Arg
                1685                1690                1695    
Ile Thr Gly Ala Pro Ala Val Ile Phe Thr Lys Val Val Ser Pro Glu
            1700                1705                1710        
Asn Leu His Thr Glu Glu Ile Leu Val Cys Gly His Ser Leu Glu Val
        1715                1720                1725            
Asn Ile Thr Thr Asn Leu Asp Phe Phe Leu Ser Val Ala Gln Val Gln
    1730                1735                1740                
Leu Leu His Gln Leu Ile Val Ala Asn Met Thr Gly Leu Glu Pro Ser
1745                1750                1755                1760
Asn Lys Ala Ala Glu Ile Ser Lys Gln Glu Gln Lys Lys Val Asp Ile
                1765                1770                1775    
Phe Asp Gly Gly Met Ala Glu Thr Ser Ser Arg Tyr Ser Gly Ala Gln
            1780                1785                1790        
Asp Ser Gly Ile Gly Ser Asp Ser Val Lys Ile Arg Ile Val Gln Ile
        1795                1800                1805            
Glu Gln His Ser Gly Ala Ser Gln His Arg Ile Ala Arg Pro Ser Arg
    1810                1815                1820                
Gln Ser Ser Ile Val Lys Asn Leu Asn Phe Ile Pro Phe Asp Ile Phe
1825                1830                1835                1840
Ile Thr Ala Ser Arg Ile Ser Leu Met Thr Tyr Ser Cys Met Ala Leu
                1845                1850                1855    
Ser Lys Ser Lys Ser Gln Glu Gln Lys Asn Asn Glu Lys Thr Asp Lys
            1860                1865                1870        
Ser Ser Leu Asn Leu Pro Glu Val Asp Ser Asp Val Ala Lys Pro Asn
        1875                1880                1885            
Gln Ala Cys Ile Ser Thr Val Thr Ala Glu Asp Leu Leu Arg Ser Ser
    1890                1895                1900                
Ile Ser Phe Pro Ser Gly Lys Lys Ile Gly Val Leu Ser Leu Glu Ser
1905                1910                1915                1920
Leu His Ala Ser Thr Arg Ser Ser Ala Arg Gln Ala Leu Gly Ile Thr
                1925                1930                1935    
Ile Val Arg Gln Pro Gly Arg Arg Gly Thr Gly Asp Leu Gln Leu Glu
            1940                1945                1950        
Pro Phe Leu Tyr Phe Ile Val Ser Gln Pro Ser Leu Leu Leu Ser Cys
        1955                1960                1965            
His His Arg Lys Gln Arg Val Glu Val Ser Ile Phe Asp Ala Val Leu
    1970                1975                1980                
Lys Gly Val Ala Ser Asp Tyr Lys Cys Ile Asp Pro Gly Lys Thr Leu
1985                1990                1995                2000
Pro Glu Ala Leu Asp Tyr Cys Thr Val Trp Leu Gln Thr Val Pro Gly
                2005                2010                2015    
Glu Ile Asp Ser Lys Ser Gly Ile Pro Pro Ser Phe Ile Thr Leu Gln
            2020                2025                2030        
Ile Lys Asp Phe Leu Asn Gly Pro Ala Asp Val Asn Leu Asp Ile Ser
        2035                2040                2045            
Lys Pro Leu Lys Ala Asn Leu Ser Phe Thr Lys Leu Asp Gln Ile Asn
    2050                2055                2060                
Leu Phe Leu Lys Lys Ile Lys Asn Ala His Ser Leu Ala His Ser Glu
2065                2070                2075                2080
Glu Thr Ser Ala Met Ser Asn Thr Met Val Asn Lys Asp Asp Leu Pro
                2085                2090                2095    
Val Ser Lys Tyr Tyr Arg Gly Lys Leu Ser Lys Pro Lys Ile His Gly
            2100                2105                2110        
Asp Gly Val Gln Lys Ile Ser Ala Gln Glu Asn Met Trp Arg Ala Val
        2115                2120                2125            
Ser Cys Phe Gln Lys Ile Ser Val Gln Thr Thr Gln Ile Val Ile Ser
    2130                2135                2140                
Met Glu Thr Val Pro His Thr Ser Lys Pro Cys Leu Leu Ala Ser Leu
2145                2150                2155                2160
Ser Asn Leu Asn Gly Ser Leu Ser Val Lys Ala Thr Gln Lys Val Pro
                2165                2170                2175    
Gly Ile Ile Leu Gly Ser Ser Phe Leu Leu Ser Ile Asn Asp Phe Leu
            2180                2185                2190        
Leu Lys Thr Ser Leu Lys Glu Arg Ser Arg Ile Leu Ile Gly Pro Cys
        2195                2200                2205            
Cys Ala Thr Ala Asn Leu Glu Ala Lys Trp Cys Lys His Ser Gly Asn
    2210                2215                2220                
Pro Gly Pro Glu Gln Ser Ile Pro Lys Ile Ser Ile Asp Leu Arg Gly
2225                2230                2235                2240
Gly Leu Leu Gln Val Phe Trp Gly Gln Glu His Leu Asn Cys Leu Val
                2245                2250                2255    
Leu Leu His Glu Leu Leu Asn Gly Tyr Leu Asn Glu Glu Gly Asn Phe
            2260                2265                2270        
Glu Val Gln Val Ser Glu Pro Val Pro Gln Met Ser Ser Pro Val Glu
        2275                2280                2285            
Lys Asn Gln Thr Phe Lys Ser Glu Gln Ser Ser Asp Asp Leu Arg Thr
    2290                2295                2300                
Gly Leu Phe Gln Tyr Val Gln Asp Ala Glu Ser Leu Lys Leu Pro Gly
2305                2310                2315                2320
Val Tyr Glu Val Leu Phe Tyr Asn Glu Thr Glu Asp Cys Pro Gly Met
                2325                2330                2335    
Met Leu Trp Arg Tyr Pro Glu Pro Arg Val Leu Thr Leu Val Arg Ile
            2340                2345                2350        
Thr Pro Val Pro Phe Asn Thr Thr Glu Asp Pro Asp Ile Ser Thr Ala
        2355                2360                2365            
Asp Leu Gly Asp Val Leu Gln Val Pro Cys Ser Leu Glu Tyr Trp Asp
    2370                2375                2380                
Glu Leu Gln Lys Val Phe Val Ala Phe Arg Glu Phe Asn Leu Ser Glu
2385                2390                2395                2400
Ser Lys Val Cys Glu Leu Gln Leu Pro Asp Ile Asn Leu Val Asn Asp
                2405                2410                2415    
Gln Lys Lys Leu Val Ser Ser Asp Leu Trp Arg Ile Val Leu Asn Ser
            2420                2425                2430        
Ser Gln Asn Gly Ala Asp Asp Gln Ser Ser Ala Ser Glu Ser Gly Ser
        2435                2440                2445            
Gln Ser Thr Cys Asp Pro Leu Val Thr Pro Thr Ala Leu Ala Ala Cys
    2450                2455                2460                
Thr Arg Val Asp Ser Cys Phe Thr Pro Trp Phe Val Pro Ser Leu Cys
2465                2470                2475                2480
Val Ser Phe Gln Phe Ala His Leu Glu Phe His Leu Cys His His Leu
                2485                2490                2495    
Asp Gln Leu Gly Thr Ala Ala Pro Gln Tyr Leu Gln Pro Phe Val Ser
            2500                2505                2510        
Asp Arg Asn Met Pro Ser Glu Leu Glu Tyr Met Ile Val Ser Phe Arg
        2515                2520                2525            
Glu Pro His Met Tyr Leu Arg Gln Trp Asn Asn Gly Ser Val Cys Gln
    2530                2535                2540                
Glu Ile Gln Phe Leu Ala Gln Ala Asp Cys Lys Leu Leu Glu Cys Arg
2545                2550                2555                2560
Asn Val Thr Met Gln Ser Val Val Lys Pro Phe Ser Ile Phe Gly Gln
                2565                2570                2575    
Met Ala Val Ser Ser Asp Val Val Glu Lys Leu Leu Asp Cys Thr Val
            2580                2585                2590        
Ile Val Asp Ser Val Phe Val Asn Leu Gly Gln His Val Val His Ser
        2595                2600                2605            
Leu Asn Thr Ala Ile Gln Ala Trp Gln Gln Asn Lys Cys Pro Glu Val
    2610                2615                2620                
Glu Glu Leu Val Phe Ser His Phe Val Ile Cys Asn Asp Thr Gln Glu
2625                2630                2635                2640
Thr Leu Arg Phe Gly Gln Val Asp Thr Asp Glu Asn Ile Leu Leu Ala
                2645                2650                2655    
Ser Leu His Ser His Gln Tyr Ser Trp Arg Ser His Lys Ser Pro Gln
            2660                2665                2670        
Leu Leu His Ile Cys Ile Glu Gly Trp Gly Asn Trp Arg Trp Ser Glu
        2675                2680                2685            
Pro Phe Ser Val Asp His Ala Gly Thr Phe Ile Arg Thr Ile Gln Tyr
    2690                2695                2700                
Arg Gly Arg Thr Ala Ser Leu Ile Ile Lys Val Gln Gln Leu Asn Gly
2705                2710                2715                2720
Val Gln Lys Gln Ile Ile Ile Cys Gly Arg Gln Ile Ile Cys Ser Tyr
                2725                2730                2735    
Leu Ser Gln Ser Ile Glu Leu Lys Val Val Gln His Tyr Ile Gly Gln
            2740                2745                2750        
Asp Gly Gln Ala Val Val Arg Glu His Phe Asp Cys Leu Thr Ala Lys
        2755                2760                2765            
Gln Lys Leu Pro Ser Tyr Ile Leu Glu Asn Asn Glu Leu Thr Glu Leu
    2770                2775                2780                
Cys Val Lys Ala Lys Gly Asp Glu Asp Trp Ser Arg Asp Val Cys Leu
2785                2790                2795                2800
Glu Ser Lys Ala Pro Glu Tyr Ser Ile Val Ile Gln Val Pro Ser Ser
                2805                2810                2815    
Asn Ser Ser Ile Ile Tyr Val Trp Cys Thr Val Leu Thr Leu Glu Pro
            2820                2825                2830        
Asn Ser Gln Val Gln Gln Arg Met Ile Val Phe Ser Pro Leu Phe Ile
        2835                2840                2845            
Met Arg Ser His Leu Pro Asp Pro Ile Ile Ile His Leu Glu Lys Arg
    2850                2855                2860                
Ser Leu Gly Leu Ser Glu Thr Gln Ile Ile Pro Gly Lys Gly Gln Glu
2865                2870                2875                2880
Lys Pro Leu Gln Asn Ile Glu Pro Asp Leu Val His His Leu Thr Phe
                2885                2890                2895    
Gln Ala Arg Glu Glu Tyr Asp Pro Ser Asp Cys Ala Val Pro Ile Ser
            2900                2905                2910        
Thr Ser Leu Ile Lys Gln Ile Ala Thr Lys Val His Pro Gly Gly Thr
        2915                2920                2925            
Val Asn Gln Ile Leu Asp Glu Phe Tyr Gly Pro Glu Lys Ser Leu Gln
    2930                2935                2940                
Pro Ile Trp Pro Tyr Asn Lys Lys Asp Ser Asp Arg Asn Glu Gln Leu
2945                2950                2955                2960
Ser Gln Trp Asp Ser Pro Met Arg Val Lys Leu Ser Ile Trp Lys Pro
                2965                2970                2975    
Tyr Val Arg Thr Leu Leu Ile Glu Leu Leu Pro Trp Ala Leu Leu Ile
            2980                2985                2990        
Asn Glu Ser Lys Trp Asp Leu Trp Leu Phe Glu Gly Glu Lys Ile Val
        2995                3000                3005            
Leu Gln Val Pro Ala Gly Lys Ile Ile Ile Pro Pro Asn Phe Gln Glu
    3010                3015                3020                
Ala Phe Gln Ile Gly Ile Tyr Trp Ala Asn Thr Asn Thr Val His Lys
3025                3030                3035                3040
Ser Val Ala Ile Lys Leu Val His Asn Leu Thr Ser Pro Lys Trp Lys
                3045                3050                3055    
Asp Gly Gly Asn Gly Glu Val Val Thr Leu Asp Glu Glu Ala Phe Val
            3060                3065                3070        
Asp Thr Glu Ile Arg Leu Gly Ala Phe Pro Gly His Gln Lys Leu Cys
        3075                3080                3085            
Gln Phe Cys Ile Ser Ser Met Val Gln Gln Gly Ile Gln Ile Ile Gln
    3090                3095                3100                
Ile Glu Asp Lys Thr Thr Ile Ile Asn Asn Thr Pro Tyr Gln Ile Phe
3105                3110                3115                3120
Tyr Lys Pro Gln Leu Ser Val Cys Asn Pro His Ser Gly Lys Glu Tyr
                3125                3130                3135    
Phe Arg Val Pro Asp Ser Ala Thr Phe Ser Ile Cys Pro Gly Gly Glu
            3140                3145                3150        
Gln Pro Ala Met Lys Ser Ser Ser Leu Pro Cys Trp Asp Leu Met Pro
        3155                3160                3165            
Asp Ile Ser Gln Ser Val Leu Asp Ala Ser Leu Leu Gln Lys Gln Ile
    3170                3175                3180                
Met Leu Gly Phe Ser Pro Ala Pro Gly Ala Asp Ser Ser Gln Cys Trp
3185                3190                3195                3200
Ser Leu Pro Ala Ile Val Arg Pro Glu Phe Pro Arg Gln Ser Val Ala
                3205                3210                3215    
Val Pro Leu Gly Asn Phe Arg Glu Asn Gly Phe Cys Thr Arg Ala Ile
            3220                3225                3230        
Val Leu Thr Tyr Gln Glu His Leu Gly Val Thr Tyr Leu Thr Leu Ser
        3235                3240                3245            
Glu Asp Pro Ser Pro Arg Val Ile Ile His Asn Arg Cys Pro Val Lys
    3250                3255                3260                
Met Leu Ile Lys Glu Asn Ile Lys Asp Ile Pro Lys Phe Glu Val Tyr
3265                3270                3275                3280
Cys Lys Lys Ile Pro Ser Glu Cys Ser Ile His His Glu Leu Tyr His
                3285                3290                3295    
Gln Ile Ser Ser Tyr Pro Asp Cys Lys Thr Lys Asp Leu Leu Pro Ser
            3300                3305                3310        
Leu Leu Leu Arg Val Glu Pro Leu Asp Glu Val Thr Thr Glu Trp Ser
        3315                3320                3325            
Asp Ala Ile Asp Ile Asn Ser Gln Gly Thr Gln Val Val Phe Leu Thr
    3330                3335                3340                
Gly Phe Gly Tyr Val Tyr Val Asp Val Val His Gln Cys Gly Thr Val
3345                3350                3355                3360
Phe Ile Thr Val Ala Pro Glu Gly Lys Ala Gly Pro Ile Leu Thr Asn
                3365                3370                3375    
Thr Asn Arg Ala Pro Glu Lys Ile Val Thr Phe Lys Met Phe Ile Thr
            3380                3385                3390        
Gln Leu Ser Leu Ala Val Phe Asp Asp Leu Thr His His Lys Ala Ser
        3395                3400                3405            
Ala Glu Leu Leu Arg Leu Thr Leu Asp Asn Ile Phe Leu Cys Val Ala
    3410                3415                3420                
Pro Gly Ala Gly Pro Leu Pro Gly Glu Glu Pro Val Ala Ala Leu Phe
3425                3430                3435                3440
Glu Leu Tyr Cys Val Glu Ile Cys Cys Gly Asp Leu Gln Leu Asp Asn
                3445                3450                3455    
Gln Leu Tyr Asn Lys Ser Asn Phe His Phe Ala Val Leu Val Cys Gln
            3460                3465                3470        
Gly Glu Lys Ala Glu Pro Ile Gln Cys Ser Lys Met Gln Ser Leu Leu
        3475                3480                3485            
Ile Ser Asn Lys Glu Leu Glu Glu Tyr Lys Glu Lys Cys Phe Ile Lys
    3490                3495                3500                
Leu Cys Ile Thr Leu Asn Glu Gly Lys Ser Ile Leu Cys Asp Ile Asn
3505                3510                3515                3520
Glu Phe Ser Phe Glu Leu Lys Pro Ala Arg Leu Tyr Val Glu Asp Thr
                3525                3530                3535    
Phe Val Tyr Tyr Ile Lys Thr Leu Phe Asp Thr Tyr Leu Pro Asn Ser
            3540                3545                3550        
Arg Leu Ala Gly His Ser Thr His Leu Ser Gly Gly Lys Gln Val Leu
        3555                3560                3565            
Pro Met Gln Val Thr Gln His Ala Arg Ala Leu Val Asn Pro Val Lys
    3570                3575                3580                
Leu Arg Lys Leu Val Ile Gln Pro Val Asn Leu Leu Val Ser Ile His
3585                3590                3595                3600
Ala Ser Leu Lys Leu Tyr Ile Ala Ser Asp His Thr Pro Leu Ser Phe
                3605                3610                3615    
Ser Val Phe Glu Arg Gly Pro Ile Phe Thr Thr Ala Arg Gln Leu Val
            3620                3625                3630        
His Ala Leu Ala Met His Tyr Ala Ala Gly Ala Leu Phe Arg Ala Gly
        3635                3640                3645            
Trp Val Val Gly Ser Leu Asp Ile Leu Gly Ser Pro Ala Ser Leu Val
    3650                3655                3660                
Arg Ser Ile Gly Asn Gly Val Ala Asp Phe Phe Arg Leu Pro Tyr Glu
3665                3670                3675                3680
Gly Leu Thr Arg Gly Pro Gly Ala Phe Val Ser Gly Val Ser Arg Gly
                3685                3690                3695    
Thr Thr Ser Phe Val Lys His Ile Ser Lys Gly Thr Leu Thr Ser Ile
            3700                3705                3710        
Thr Asn Leu Ala Thr Ser Leu Ala Arg Asn Met Asp Arg Leu Ser Leu
        3715                3720                3725            
Asp Glu Glu His Tyr Asn Arg Gln Glu Glu Trp Arg Arg Gln Leu Pro
    3730                3735                3740                
Glu Ser Leu Gly Glu Gly Leu Arg Gln Gly Leu Ser Arg Leu Gly Ile
3745                3750                3755                3760
Ser Leu Leu Gly Ala Ile Ala Gly Ile Val Asp Gln Pro Met Gln Asn
                3765                3770                3775    
Phe Gln Lys Thr Ser Glu Ala Gln Ala Ser Ala Gly His Lys Ala Lys
            3780                3785                3790        
Gly Val Ile Ser Gly Val Gly Lys Gly Ile Met Gly Val Phe Thr Lys
        3795                3800                3805            
Pro Ile Gly Gly Ala Ala Glu Leu Val Ser Gln Thr Gly Tyr Gly Ile
    3810                3815                3820                
Leu His Gly Ala Gly Leu Ser Gln Leu Pro Lys Gln Arg His Gln Pro
3825                3830                3835                3840
Ser Asp Leu His Ala Asp Gln Ala Pro Asn Ser His Val Lys Tyr Val
                3845                3850                3855    
Trp Lys Met Leu Gln Ser Leu Gly Arg Pro Glu Val His Met Ala Leu
            3860                3865                3870        
Asp Val Val Leu Val Arg Gly Ser Gly Gln Glu His Glu Gly Cys Leu
        3875                3880                3885            
Leu Leu Thr Ser Glu Val Leu Phe Val Val Ser Val Ser Glu Asp Thr
    3890                3895                3900                
Gln Gln Gln Ala Phe Pro Val Thr Glu Ile Asp Cys Ala Gln Asp Ser
3905                3910                3915                3920
Lys Gln Asn Asn Leu Leu Thr Val Gln Leu Lys Gln Pro Arg Val Ala
                3925                3930                3935    
Cys Asp Val Glu Val Asp Gly Val Arg Glu Arg Leu Ser Glu Gln Gln
            3940                3945                3950        
Tyr Asn Arg Leu Val Asp Tyr Ile Thr Lys Thr Ser Cys His Leu Ala
        3955                3960                3965            
Pro Ser Cys Ser Ser Met Gln Ile Pro Cys Pro Val Val Ala Ala Glu
    3970                3975                3980                
Pro Pro Pro Ser Thr Val Lys Thr Tyr His Tyr Leu Val Asp Pro His
3985                3990                3995                4000
Phe Ala Gln Val Phe Leu Ser Lys Phe Thr Met Val Lys Asn Lys Ala
                4005                4010                4015    
Leu Arg Lys Gly Phe Pro
            4020        


<210> 8121
<211> 863
<212> PRT
<213> Homo sapiens

<400> 8121
Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg
 1               5                  10                  15      
Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly
            20                  25                  30          
Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu
        35                  40                  45              
Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu
    50                  55                  60                  
Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val
65                  70                  75                  80  
Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile
                85                  90                  95      
Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr
            100                 105                 110         
Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala
        115                 120                 125             
Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile
    130                 135                 140                 
Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu
145                 150                 155                 160 
Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala
                165                 170                 175     
Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile
            180                 185                 190         
Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys
        195                 200                 205             
Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr
    210                 215                 220                 
Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe
225                 230                 235                 240 
Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His
                245                 250                 255     
Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro
            260                 265                 270         
Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu
        275                 280                 285             
Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn
    290                 295                 300                 
Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile
305                 310                 315                 320 
Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln
                325                 330                 335     
Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe
            340                 345                 350         
Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly
        355                 360                 365             
Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys
    370                 375                 380                 
Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr
385                 390                 395                 400 
Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln
                405                 410                 415     
Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr
            420                 425                 430         
Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly
        435                 440                 445             
Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys
    450                 455                 460                 
Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe
465                 470                 475                 480 
Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn
                485                 490                 495     
Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu
            500                 505                 510         
Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala
        515                 520                 525             
Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Val
    530                 535                 540                 
Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser
545                 550                 555                 560 
Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser
                565                 570                 575     
Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His
            580                 585                 590         
Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro
        595                 600                 605             
Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asn Glu Asn Glu Thr Ile Leu
    610                 615                 620                 
Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His
625                 630                 635                 640 
Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu
                645                 650                 655     
Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn
            660                 665                 670         
Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu
        675                 680                 685             
Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val
    690                 695                 700                 
Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln
705                 710                 715                 720 
Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys
                725                 730                 735     
Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser
            740                 745                 750         
Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr
        755                 760                 765             
Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile
    770                 775                 780                 
Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala
785                 790                 795                 800 
Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser
                805                 810                 815     
His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn
            820                 825                 830         
Glu Ile Phe Leu Ser Ile Glu Ile Gly Ser Cys Tyr Val Ala Gln Val
        835                 840                 845             
Asp Leu Glu Leu Leu Ala Ser Asn Asp Pro Pro Thr Ser Thr Ser
    850                 855                 860             


<210> 8122
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 8122
Met Leu Glu Ser Tyr Val Thr Pro Ile Leu Met Ser Tyr Val Asn Arg
 1               5                  10                  15      
Tyr Ile Lys Asn Leu Lys Pro Ser Asp Leu Gln Leu Ser Leu Trp Gly
            20                  25                  30          
Gly Asp Val Val Leu Ser Lys Leu Glu Leu Lys Leu Asp Val Leu Glu
        35                  40                  45              
Gln Glu Leu Lys Leu Pro Phe Thr Phe Leu Ser Gly His Ile His Glu
    50                  55                  60                  
Leu Arg Ile His Val Pro Trp Thr Lys Leu Gly Ser Glu Pro Val Val
65                  70                  75                  80  
Ile Thr Ile Asn Thr Met Glu Cys Ile Leu Lys Leu Lys Asp Gly Ile
                85                  90                  95      
Gln Asp Asp His Glu Ser Cys Gly Ser Asn Ser Thr Asn Arg Ser Thr
            100                 105                 110         
Ala Glu Ser Thr Lys Ser Ser Ile Lys Pro Arg Arg Met Gln Gln Ala
        115                 120                 125             
Ala Pro Thr Asp Pro Asp Leu Pro Pro Gly Tyr Val Gln Ser Leu Ile
    130                 135                 140                 
Arg Arg Val Val Asn Asn Val Asn Ile Val Ile Asn Asn Leu Ile Leu
145                 150                 155                 160 
Lys Tyr Val Glu Asp Asp Ile Val Leu Ser Val Asn Ile Thr Ser Ala
                165                 170                 175     
Glu Cys Tyr Thr Val Gly Glu Leu Trp Asp Arg Ala Phe Met Asp Ile
            180                 185                 190         
Ser Ala Thr Asp Leu Val Leu Arg Lys Val Ile Asn Phe Ser Asp Cys
        195                 200                 205             
Thr Val Cys Leu Asp Lys Arg Asn Ala Ser Gly Lys Ile Glu Phe Tyr
    210                 215                 220                 
Gln Asp Pro Leu Leu Tyr Lys Cys Ser Phe Arg Thr Arg Leu His Phe
225                 230                 235                 240 
Thr Tyr Glu Asn Leu Asn Ser Lys Met Pro Ser Val Ile Lys Ile His
                245                 250                 255     
Thr Leu Val Glu Ser Leu Lys Leu Ser Ile Thr Asp Gln Gln Leu Pro
            260                 265                 270         
Met Phe Ile Arg Ile Met Gln Leu Gly Ile Ala Leu Tyr Tyr Gly Glu
        275                 280                 285             
Ile Gly Asn Phe Lys Glu Gly Glu Ile Glu Asp Leu Thr Cys His Asn
    290                 295                 300                 
Lys Asp Met Leu Gly Asn Ile Thr Gly Ser Glu Asp Glu Thr Arg Ile
305                 310                 315                 320 
Asp Met Gln Tyr Pro Ala Gln His Lys Gly Gln Glu Leu Tyr Ser Gln
                325                 330                 335     
Gln Asp Glu Glu Gln Pro Gln Gly Trp Val Ser Trp Ala Trp Ser Phe
            340                 345                 350         
Val Pro Ala Ile Val Ser Tyr Asp Asp Gly Glu Glu Asp Phe Val Gly
        355                 360                 365             
Asn Asp Pro Ala Ser Thr Met His Gln Gln Lys Ala Gln Thr Leu Lys
    370                 375                 380                 
Asp Pro Ile Val Ser Ile Gly Phe Tyr Cys Thr Lys Ala Thr Val Thr
385                 390                 395                 400 
Phe Lys Leu Thr Glu Met Gln Val Glu Ser Ser Tyr Tyr Ser Pro Gln
                405                 410                 415     
Lys Val Lys Ser Lys Glu Val Leu Cys Trp Glu Gln Glu Gly Thr Thr
            420                 425                 430         
Val Glu Ala Leu Met Met Gly Glu Pro Phe Phe Asp Cys Gln Ile Gly
        435                 440                 445             
Phe Val Gly Cys Arg Ala Met Cys Leu Lys Gly Ile Met Gly Val Lys
    450                 455                 460                 
Asp Phe Glu Glu Asn Met Asn Arg Ser Glu Thr Glu Ala Cys Phe Phe
465                 470                 475                 480 
Ile Cys Gly Asp Asn Leu Ser Thr Lys Gly Phe Thr Tyr Leu Thr Asn
                485                 490                 495     
Ser Leu Phe Asp Tyr Arg Ser Pro Glu Asn Asn Gly Thr Arg Ala Glu
            500                 505                 510         
Phe Ile Leu Asp Ser Thr His His Lys Glu Thr Tyr Thr Glu Ile Ala
        515                 520                 525             
Gly Met Gln Arg Phe Gly Ala Phe Tyr Met Asp Tyr Leu Tyr Thr Val
    530                 535                 540                 
Glu Asn Thr Ser Gly Lys Gly Ser Thr Asn Gln Gln Asp Phe Ser Ser
545                 550                 555                 560 
Gly Lys Ser Glu Asp Leu Gly Thr Val Gln Glu Lys Ser Thr Lys Ser
                565                 570                 575     
Leu Val Ile Gly Pro Leu Asp Phe Arg Leu Asp Ser Ser Ala Val His
            580                 585                 590         
Arg Ile Leu Lys Met Ile Val Cys Ala Leu Glu His Glu Tyr Glu Pro
        595                 600                 605             
Tyr Ser Arg Leu Lys Ser Asp Ile Lys Asn Glu Asn Glu Thr Ile Leu
    610                 615                 620                 
Asn Pro Glu Glu Val Ala Leu Leu Glu Glu Tyr Ile Pro Thr Arg His
625                 630                 635                 640 
Thr Ser Val Thr Leu Leu Lys Cys Thr Cys Thr Ile Ser Met Ala Glu
                645                 650                 655     
Phe Asn Leu Leu Asp His Leu Leu Pro Val Ile Met Gly Glu Lys Asn
            660                 665                 670         
Ser Ser Asn Phe Met Asn Thr Thr Asn Phe Gln Ser Leu Arg Pro Leu
        675                 680                 685             
Pro Ser Ile Arg Ile Leu Val Asp Lys Ile Asn Leu Glu His Ser Val
    690                 695                 700                 
Pro Met Tyr Ala Glu Gln Leu Val His Val Val Ser Ser Leu Thr Gln
705                 710                 715                 720 
Pro Ser Asp Asn Leu Leu His Tyr Cys Tyr Val His Cys Tyr Leu Lys
                725                 730                 735     
Ile Phe Gly Phe Gln Ala Gly Leu Thr Ser Leu Asp Cys Ser Gly Ser
            740                 745                 750         
Tyr Cys Leu Pro Val Pro Val Ile Pro Ser Phe Ser Thr Ala Leu Tyr
        755                 760                 765             
Gly Lys Leu Leu Lys Leu Pro Thr Cys Trp Thr Lys Arg Ser Gln Ile
    770                 775                 780                 
Ala Ile Thr Glu Gly Ile Phe Glu Leu Pro Asn Leu Thr Ile Gln Ala
785                 790                 795                 800 
Thr Arg Ala Gln Thr Leu Leu Leu Gln Ala Ile Tyr Gln Ser Trp Ser
                805                 810                 815     
His Leu Gly Asn Val Ser Ser Ser Ala Val Ile Glu Ala Leu Ile Asn
            820                 825                 830         
Glu Ile Phe Leu Ser Ile Gly Val Lys Ser Lys Asn Pro Leu Pro Thr
        835                 840                 845             
Leu Glu Gly Ser Ile Gln Asn Val Glu Leu Lys Tyr Cys Ser Thr Ser
    850                 855                 860                 
Leu Val Lys Cys Ala Ser Gly Thr Met Gly Ser Ile Lys Ile Cys Ala
865                 870                 875                 880 
Lys Ala Pro Val Asp Ser Gly Lys Glu Lys Leu Ile Pro Leu Leu Gln
                885                 890                 895     
Gly Pro Ser Asp Thr Lys Asp Leu His Ser Thr Lys Trp Leu Asn Glu
            900                 905                 910         
Ser Arg Lys Pro Glu Ser Leu Leu Ala Pro Asp Leu Met Ala Phe Thr
        915                 920                 925             
Ile Gln Val Pro Gln Tyr Ile Asp Tyr Cys His Asn Ser Gly Ala Val
    930                 935                 940                 
Leu Leu Cys Ser Ile Gln Gly Leu Ala Val Asn Ile Asp Pro Ile Leu
945                 950                 955                 960 
Tyr Thr Trp Leu Ile Tyr Gln Pro Gln Lys Arg Thr Ser Arg His Met
                965                 970                 975     
Gln Gln Gln Pro Val Val Ala Val Pro Leu Val Met Pro Val Cys Arg
            980                 985                 990         
Arg Lys Glu Asp Glu Val Ser Ile Gly Ser Ala Pro Leu Ala Lys Gln
        995                 1000                1005            
Gln Ser Tyr Gln Ala Ser Glu Tyr Ala Ser Ser Pro Val Lys Thr Lys
    1010                1015                1020                
Thr Val Thr Glu Ser Arg Pro Leu Ser Val Pro Val Lys Ala Met Leu
1025                1030                1035                1040
Asn Ile Ser Glu Ser Cys Arg Ser Pro Glu Glu Arg Met Lys Glu Phe
                1045                1050                1055    
Ile Gly Ile Val Trp Asn Ala Val Lys His Leu Thr Leu Gln Leu Glu
            1060                1065                1070        
Val Gln Ser Cys Cys Val Phe Ile Pro Asn Asp Ser Leu Pro Ser Pro
        1075                1080                1085            
Ser Thr Ile Val Ser Gly Asp Ile Pro Gly Thr Val Arg Ser Trp Tyr
    1090                1095                1100                
His Gly Gln Thr Ser Met Pro Gly Thr Leu Val Leu Cys Leu Pro Gln
1105                1110                1115                1120
Ile Lys Ile Ile Ser Ala Gly His Lys Tyr Met Glu Pro Leu Gln Glu
                1125                1130                1135    
Ile Pro Phe Val Ile Pro Arg Pro Ile Leu Glu Glu Gly Asp Ala Phe
            1140                1145                1150        
Pro Trp Thr Ile Ser Leu His Asn Phe Ser Ile Tyr Thr Leu Leu Gly
        1155                1160                1165            
Lys Gln Val Thr Leu Cys Leu Val Glu Pro Met Gly Cys Thr Ser Thr
    1170                1175                1180                
Leu Ala Val Thr Ser Gln Lys Leu Leu Ala Thr Gly Pro Asp Thr Arg
1185                1190                1195                1200
His Ser Phe Val Val Cys Leu His Val Asp Leu Glu Ser Leu Glu Ile
                1205                1210                1215    
Lys Cys Ser Asn Pro Gln Val Gln Leu Phe Tyr Glu Leu Thr Asp Ile
            1220                1225                1230        
Met Asn Lys Val Trp Asn Lys Ile Gln Lys Arg Gly Asn Leu Asn Leu
        1235                1240                1245            
Ser Pro Thr Ser Pro Glu Thr Met Ala Gly Pro Val Pro Thr Ser Pro
    1250                1255                1260                
Val Arg Ser Ser Ile Gly Thr Ala Pro Pro Asp Thr Ser Thr Cys Ser
1265                1270                1275                1280
Pro Ser Ala Asp Ile Gly Thr Thr Thr Glu Gly Asp Ser Ile Gln Ala
                1285                1290                1295    
Gly Glu Glu Ser Pro Phe Ser Asp Ser Val Thr Leu Glu Gln Thr Thr
            1300                1305                1310        
Ser Asn Ile Gly Gly Thr Ser Gly Arg Val Ser Leu Trp Met Gln Trp
        1315                1320                1325            
Val Leu Pro Lys Ile Thr Ile Lys Leu Phe Ala Pro Asp Pro Glu Asn
    1330                1335                1340                
Lys Gly Thr Glu Val Cys Met Val Ser Glu Leu Glu Asp Leu Ser Ala
1345                1350                1355                1360
Ser Ile Asp Val Gln Asp Val Tyr Thr Lys Val Lys Cys Lys Ile Glu
                1365                1370                1375    
Ser Phe Asn Ile Asp His Tyr Arg Ser Arg Pro Gly Glu Gly Trp Gln
            1380                1385                1390        
Ser Gly His Phe Glu Gly Val Phe Leu Gln Cys Lys Glu Lys Ser Val
        1395                1400                1405            
Pro Trp Gly Arg Val Leu Val Phe Gly Ala Met Trp Arg Cys Leu Pro
    1410                1415                1420                
Phe Leu Tyr
1425        


<210> 8123
<211> 1188
<212> PRT
<213> Homo sapiens

<400> 8123
Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Thr Val Gly Thr Asp Val
 1               5                  10                  15      
Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Val
            20                  25                  30          
Lys Arg Leu Val Lys Val Lys Val Leu Leu Lys Gln Asp Asn Thr Thr
        35                  40                  45              
Gln Leu Val Gln Asp Asp Gln Val Lys Gly Pro Leu Arg Val Gly Ala
    50                  55                  60                  
Ile Val Glu Thr Arg Thr Ser Asp Gly Ser Phe Gln Glu Ala Ile Ile
65                  70                  75                  80  
Ser Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly
                85                  90                  95      
Asp Glu Arg Thr Leu Arg Arg Thr Ser Leu Cys Leu Lys Gly Glu Arg
            100                 105                 110         
His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro
        115                 120                 125             
Glu His Phe Gly Thr Pro Val Ile Ala Lys Lys Thr Asn Arg Gly Arg
    130                 135                 140                 
Arg Ser Ser Leu Pro Val Thr Glu Asp Glu Lys Glu Glu Glu Ser Ser
145                 150                 155                 160 
Glu Glu Glu Asp Glu Asp Lys Arg Arg Leu Asn Asp Glu Leu Leu Gly
                165                 170                 175     
Lys Val Val Ser Val Val Ser Ala Thr Glu Arg Thr Glu Trp Tyr Pro
            180                 185                 190         
Ala Leu Val Ile Ser Pro Ser Cys Asn Asp Asp Ile Thr Val Lys Lys
        195                 200                 205             
Asp Gln Cys Leu Val Arg Ser Phe Ile Asp Ser Lys Phe Tyr Ser Ile
    210                 215                 220                 
Ala Arg Lys Asp Ile Lys Glu Val Asp Ile Leu Asn Leu Pro Glu Ser
225                 230                 235                 240 
Glu Leu Ser Thr Lys Pro Gly Leu Gln Lys Ala Ser Ile Phe Leu Lys
                245                 250                 255     
Thr Arg Val Val Pro Asp Asn Trp Lys Met Asp Ile Ser Glu Ile Leu
            260                 265                 270         
Glu Ser Ser Ser Ser Asp Asp Glu Asp Gly Pro Ala Glu Glu Asn Asp
        275                 280                 285             
Glu Glu Lys Glu Lys Glu Ala Lys Lys Thr Glu Glu Glu Val Pro Glu
    290                 295                 300                 
Glu Glu Leu Asp Pro Glu Glu Arg Asp Asn Phe Leu Gln Gln Leu Tyr
305                 310                 315                 320 
Lys Phe Met Glu Asp Arg Gly Thr Pro Ile Asn Lys Pro Pro Val Leu
                325                 330                 335     
Gly Tyr Lys Asp Leu Asn Leu Phe Lys Leu Phe Arg Leu Val Tyr His
            340                 345                 350         
Gln Gly Gly Cys Asp Asn Ile Asp Ser Gly Ala Val Trp Lys Gln Ile
        355                 360                 365             
Tyr Met Asp Leu Gly Ile Pro Ile Leu Asn Ser Ala Ala Ser Tyr Asn
    370                 375                 380                 
Leu Lys Thr Ala Tyr Arg Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys
385                 390                 395                 400 
Arg Ser Ala Asn Ile Gln Phe Arg Thr Val His His His Glu Pro Lys
                405                 410                 415     
Val Lys Glu Glu Lys Lys Asp Leu Glu Glu Ser Met Glu Glu Ala Leu
            420                 425                 430         
Lys Leu Asp Gln Glu Met Pro Leu Thr Glu Val Lys Ser Glu Pro Glu
        435                 440                 445             
Glu Asn Ile Asp Ser Asn Ser Glu Ser Glu Arg Glu Glu Ile Glu Leu
    450                 455                 460                 
Lys Ser Pro Arg Gly Arg Arg Arg Ile Ala Arg Asp Val Asn Ser Ile
465                 470                 475                 480 
Lys Lys Glu Ile Glu Glu Glu Lys Thr Glu Asp Lys Leu Lys Asp Asn
                485                 490                 495     
Asp Thr Glu Asn Lys Asp Val Asp Asp Asp Tyr Glu Thr Ala Glu Lys
            500                 505                 510         
Lys Glu Asn Glu Leu Leu Leu Gly Arg Lys Asn Thr Pro Lys Gln Lys
        515                 520                 525             
Glu Lys Lys Ile Lys Lys Gln Glu Asp Ser Asp Lys Asp Ser Asp Glu
    530                 535                 540                 
Glu Glu Glu Lys Ser Gln Glu Arg Glu Glu Thr Glu Ser Lys Cys Asp
545                 550                 555                 560 
Ser Glu Gly Glu Glu Asp Glu Glu Asp Met Glu Pro Cys Leu Thr Gly
                565                 570                 575     
Thr Lys Val Lys Val Lys Tyr Gly Arg Gly Lys Thr Gln Lys Ile Tyr
            580                 585                 590         
Glu Ala Ser Ile Lys Ser Thr Glu Ile Asp Asp Gly Glu Val Leu Tyr
        595                 600                 605             
Leu Val His Tyr Tyr Gly Trp Asn Val Ser Tyr Asp Glu Trp Val Lys
    610                 615                 620                 
Ala Asp Arg Ile Ile Trp Pro Leu Asp Lys Gly Gly Pro Lys Lys Lys
625                 630                 635                 640 
Gln Lys Lys Lys Ala Lys Asn Lys Glu Asp Ser Glu Lys Asp Glu Lys
                645                 650                 655     
Arg Asp Glu Glu Arg Gln Lys Ser Lys Arg Gly Arg Pro Pro Leu Lys
            660                 665                 670         
Ser Thr Leu Ser Ser Asn Met Pro Tyr Gly Leu Ser Lys Thr Ala Asn
        675                 680                 685             
Ser Glu Gly Lys Ser Asp Ser Cys Ser Ser Asp Ser Glu Thr Glu Asp
    690                 695                 700                 
Ala Leu Glu Lys Asn Leu Ile Asn Glu Glu Leu Ser Leu Lys Asp Glu
705                 710                 715                 720 
Leu Glu Lys Asn Glu Asn Leu Asn Asp Asp Lys Leu Asp Glu Glu Asn
                725                 730                 735     
Pro Lys Ile Ser Ala His Ile Leu Lys Glu Asn Asp Arg Thr Gln Met
            740                 745                 750         
Gln Pro Leu Glu Thr Leu Lys Leu Glu Val Gly Glu Asn Glu Gln Ile
        755                 760                 765             
Val Gln Ile Phe Gly Asn Lys Met Glu Lys Ala Glu Glu Val Lys Lys
    770                 775                 780                 
Glu Ala Glu Lys Ser Pro Lys Gly Lys Gly Arg Arg Ser Lys Thr Lys
785                 790                 795                 800 
Asp Leu Ser Leu Glu Ile Ile Lys Ile Ser Ser Phe Gly Gln Asn Glu
                805                 810                 815     
Ala Gly Ser Glu Pro His Ile Glu Ala His Ser Leu Glu Leu Ser Ser
            820                 825                 830         
Leu Asp Asn Lys Asn Phe Ser Ser Ala Thr Glu Asp Glu Ile Asp Gln
        835                 840                 845             
Cys Val Lys Glu Lys Lys Leu Lys Arg Lys Ile Leu Gly Gln Ser Ser
    850                 855                 860                 
Pro Glu Lys Lys Ile Arg Ile Glu Asn Gly Met Glu Met Thr Asn Thr
865                 870                 875                 880 
Val Ser Gln Glu Arg Thr Ser Asp Cys Ile Gly Ser Glu Gly Met Lys
                885                 890                 895     
Asn Leu Asn Phe Glu Gln His Phe Glu Arg Glu Asn Glu Gly Met Pro
            900                 905                 910         
Ser Leu Ile Ala Glu Ser Asn Gln Cys Ile Gln Gln Leu Thr Ser Glu
        915                 920                 925             
Arg Phe Asp Ser Pro Ala Glu Glu Thr Val Asn Ile Pro Leu Lys Glu
    930                 935                 940                 
Asp Glu Asp Ala Met Pro Leu Ile Gly Pro Glu Thr Leu Val Cys His
945                 950                 955                 960 
Glu Val Asp Leu Asp Asp Leu Asp Glu Lys Asp Lys Thr Ser Ile Glu
                965                 970                 975     
Asp Val Ala Val Glu Ser Ser Glu Ser Asn Ser Leu Val Ser Ile Pro
            980                 985                 990         
Pro Ala Leu Pro Pro Val Val Gln His Asn Phe Ser Val Ala Ser Pro
        995                 1000                1005            
Leu Thr Leu Ser Gln Asp Glu Ser Arg Ser Val Lys Ser Glu Ser Asp
    1010                1015                1020                
Ile Thr Ile Glu Val Asp Ser Ile Ala Glu Glu Ser Gln Glu Gly Leu
1025                1030                1035                1040
Cys Glu Arg Glu Ser Ala Asn Gly Phe Glu Thr Asn Val Ala Ser Gly
                1045                1050                1055    
Thr Cys Ser Ile Ile Val Gln Glu Arg Glu Ser Arg Glu Lys Gly Gln
            1060                1065                1070        
Lys Arg Pro Ser Asp Gly Asn Ser Gly Leu Met Ala Lys Lys Gln Lys
        1075                1080                1085            
Arg Thr Pro Lys Arg Thr Ser Ala Ala Ala Lys Asn Glu Lys Asn Gly
    1090                1095                1100                
Thr Asp Glu Leu Asp Asn Met Asn Ser Thr Glu Arg Ile Ser Phe Leu
1105                1110                1115                1120
Gln Glu Lys Leu Gln Glu Ile Arg Lys Tyr Tyr Met Ser Leu Lys Ser
                1125                1130                1135    
Glu Val Ala Thr Ile Asp Arg Arg Arg Lys Arg Leu Lys Lys Lys Asp
            1140                1145                1150        
Arg Glu Val Ser His Ala Gly Ala Ser Met Ser Ser Ala Ser Ser Asp
        1155                1160                1165            
Thr Gly Met Ser Pro Ser Ser Ser Ser Pro Pro Gln Asn Val Leu Ala
    1170                1175                1180                
Val Glu Cys Arg
1185            


<210> 8124
<211> 39
<212> PRT
<213> Homo sapiens

<400> 8124
Met Glu Pro Gln Val Thr Leu Asn Val Thr Phe Lys Asn Glu Ile Gln
 1               5                  10                  15      
Ser Phe Leu Val Ser Asp Pro Glu Asn Thr Thr Trp Ala Asp Ile Glu
            20                  25                  30          
Ala Met Val Ser Val Thr Leu
        35                  


<210> 8125
<211> 713
<212> PRT
<213> Homo sapiens

<400> 8125
Met Ala Thr Gly Gln Asp Arg Val Val Ala Leu Val Asp Met Asp Cys
 1               5                  10                  15      
Phe Phe Val Gln Val Glu Gln Arg Gln Asn Pro His Leu Arg Asn Lys
            20                  25                  30          
Pro Cys Ala Val Val Gln Tyr Lys Ser Trp Lys Gly Gly Gly Ile Ile
        35                  40                  45              
Ala Val Ser Tyr Glu Ala Arg Ala Phe Gly Val Thr Arg Ser Met Trp
    50                  55                  60                  
Ala Asp Asp Ala Lys Lys Leu Cys Pro Asp Leu Leu Leu Ala Gln Val
65                  70                  75                  80  
Arg Glu Ser Arg Gly Lys Ala Asn Leu Thr Lys Tyr Arg Glu Ala Ser
                85                  90                  95      
Val Glu Val Met Glu Ile Met Ser Arg Phe Ala Val Ile Glu Arg Ala
            100                 105                 110         
Ser Ile Asp Glu Ala Tyr Val Asp Leu Thr Ser Ala Val Gln Glu Arg
        115                 120                 125             
Leu Gln Lys Leu Gln Gly Gln Pro Ile Ser Ala Asp Leu Leu Pro Ser
    130                 135                 140                 
Thr Tyr Ile Glu Gly Leu Pro Gln Gly Pro Thr Thr Ala Glu Glu Thr
145                 150                 155                 160 
Val Gln Lys Glu Gly Met Arg Lys Gln Gly Leu Phe Gln Trp Leu Asp
                165                 170                 175     
Ser Leu Gln Ile Asp Asn Leu Thr Ser Pro Asp Leu Gln Leu Thr Val
            180                 185                 190         
Gly Ala Val Ile Val Glu Glu Met Arg Ala Ala Ile Glu Arg Glu Thr
        195                 200                 205             
Gly Phe Gln Cys Ser Ala Gly Ile Ser His Asn Lys Val Leu Ala Lys
    210                 215                 220                 
Leu Ala Cys Gly Leu Asn Lys Pro Asn Arg Gln Thr Leu Val Ser His
225                 230                 235                 240 
Gly Ser Val Pro Gln Leu Phe Ser Gln Met Pro Ile Arg Lys Ile Arg
                245                 250                 255     
Ser Leu Gly Gly Lys Leu Gly Ala Ser Val Ile Glu Ile Leu Gly Ile
            260                 265                 270         
Glu Tyr Met Gly Glu Leu Thr Gln Phe Thr Glu Ser Gln Leu Gln Ser
        275                 280                 285             
His Phe Gly Glu Lys Asn Gly Ser Trp Leu Tyr Ala Met Cys Arg Gly
    290                 295                 300                 
Ile Glu His Asp Pro Val Lys Pro Arg Gln Leu Pro Lys Thr Ile Gly
305                 310                 315                 320 
Cys Ser Lys Asn Phe Pro Gly Lys Thr Ala Leu Ala Thr Arg Glu Gln
                325                 330                 335     
Val Gln Trp Trp Leu Leu Gln Leu Ala Gln Glu Leu Glu Glu Arg Leu
            340                 345                 350         
Thr Lys Asp Arg Asn Asp Asn Asp Arg Val Ala Thr Gln Leu Val Val
        355                 360                 365             
Ser Ile Arg Val Gln Gly Asp Lys Arg Leu Ser Ser Leu Arg Arg Cys
    370                 375                 380                 
Cys Ala Leu Thr Arg Tyr Asp Ala His Lys Met Ser His Asp Ala Phe
385                 390                 395                 400 
Thr Val Ile Lys Asn Cys Asn Thr Ser Gly Ile Gln Thr Glu Trp Ser
                405                 410                 415     
Pro Pro Leu Thr Met Leu Phe Leu Cys Ala Thr Lys Phe Ser Ala Ser
            420                 425                 430         
Ala Pro Ser Ser Ser Thr Asp Ile Thr Ser Phe Leu Ser Ser Asp Pro
        435                 440                 445             
Ser Ser Leu Pro Lys Val Pro Val Thr Ser Ser Glu Ala Lys Thr Gln
    450                 455                 460                 
Gly Ser Gly Pro Ala Val Thr Ala Thr Lys Lys Ala Thr Thr Ser Leu
465                 470                 475                 480 
Glu Ser Phe Phe Gln Lys Ala Ala Glu Arg Gln Lys Val Lys Glu Ala
                485                 490                 495     
Ser Leu Ser Ser Leu Thr Ala Pro Thr Gln Ala Pro Met Ser Asn Ser
            500                 505                 510         
Pro Ser Lys Pro Ser Leu Pro Phe Gln Thr Ser Gln Ser Thr Gly Thr
        515                 520                 525             
Glu Pro Phe Phe Lys Gln Lys Ser Leu Leu Leu Lys Gln Lys Gln Leu
    530                 535                 540                 
Asn Asn Ser Ser Val Ser Ser Pro Gln Gln Asn Pro Trp Ser Asn Cys
545                 550                 555                 560 
Lys Ala Leu Pro Asn Ser Leu Pro Thr Glu Tyr Pro Gly Cys Val Pro
                565                 570                 575     
Val Cys Glu Gly Val Ser Lys Leu Glu Glu Ser Ser Lys Ala Thr Pro
            580                 585                 590         
Ala Glu Met Asp Leu Ala His Asn Ser Gln Ser Met His Ala Ser Ser
        595                 600                 605             
Ala Ser Lys Ser Val Leu Glu Val Thr Gln Lys Ala Thr Pro Asn Pro
    610                 615                 620                 
Ser Leu Leu Ala Ala Glu Asp Gln Val Pro Cys Glu Lys Cys Gly Ser
625                 630                 635                 640 
Leu Val Pro Val Trp Asp Met Pro Glu His Met Asp Tyr His Phe Ala
                645                 650                 655     
Leu Glu Leu Gln Lys Ser Phe Leu Gln Pro His Ser Ser Asn Pro Gln
            660                 665                 670         
Val Val Ser Ala Val Ser His Gln Gly Lys Arg Asn Pro Lys Ser Pro
        675                 680                 685             
Leu Ala Cys Thr Asn Lys Arg Pro Arg Pro Glu Gly Met Gln Thr Leu
    690                 695                 700                 
Glu Ser Phe Phe Lys Pro Leu Thr His
705                 710             


<210> 8126
<211> 353
<212> PRT
<213> Homo sapiens

<400> 8126
Met Ser Thr Leu Leu Leu Asn Leu Asp Phe Gly Glu Pro Pro Pro Lys
 1               5                  10                  15      
Lys Ala Leu Glu Gly Asn Ala Lys His Arg Asn Phe Val Lys Lys Arg
            20                  25                  30          
Arg Leu Leu Glu Arg Arg Gly Phe Leu Ser Lys Lys Asn Gln Pro Pro
        35                  40                  45              
Ser Lys Ala Pro Lys Leu His Ser Glu Pro Ser Lys Lys Gly Glu Thr
    50                  55                  60                  
Pro Thr Val Asp Gly Thr Trp Lys Thr Pro Ser Phe Pro Lys Lys Lys
65                  70                  75                  80  
Thr Ala Ala Ser Ser Asn Gly Ser Gly Gln Pro Leu Asp Lys Lys Ala
                85                  90                  95      
Ala Val Ser Trp Leu Thr Pro Ala Pro Ser Lys Lys Ala Asp Ser Val
            100                 105                 110         
Ala Ala Lys Val Asp Leu Leu Gly Glu Phe Gln Ser Ala Leu Pro Lys
        115                 120                 125             
Ile Asn Ser His Pro Thr Arg Ser Gln Lys Lys Ser Ser Gln Lys Lys
    130                 135                 140                 
Ser Ser Lys Lys Asn His Pro Gln Lys Asn Ala Pro Gln Asn Ser Thr
145                 150                 155                 160 
Gln Ala His Ser Glu Asn Lys Cys Ser Gly Ala Ser Gln Lys Leu Pro
                165                 170                 175     
Arg Lys Met Val Ala Ile Asp Cys Glu Met Val Gly Thr Gly Pro Lys
            180                 185                 190         
Gly His Val Ser Ser Leu Ala Arg Cys Ser Ile Val Asn Tyr Asn Gly
        195                 200                 205             
Asp Val Leu Tyr Asp Glu Tyr Ile Leu Pro Pro Cys His Ile Val Asp
    210                 215                 220                 
Tyr Arg Thr Arg Trp Ser Gly Ile Arg Lys Gln His Met Val Asn Ala
225                 230                 235                 240 
Thr Pro Phe Lys Ile Ala Arg Gly Gln Ile Leu Lys Ile Leu Thr Gly
                245                 250                 255     
Lys Ile Val Val Gly His Ala Ile His Asn Asp Phe Lys Ala Leu Gln
            260                 265                 270         
Tyr Phe His Pro Lys Ser Leu Thr Arg Asp Thr Ser His Ile Pro Pro
        275                 280                 285             
Leu Asn Arg Lys Ala Asp Cys Pro Glu Asn Ala Thr Met Ser Leu Lys
    290                 295                 300                 
His Leu Thr Lys Lys Leu Leu Asn Arg Asp Ile Gln Val Gly Lys Ser
305                 310                 315                 320 
Gly His Ser Ser Val Glu Asp Ala Gln Ala Thr Met Glu Leu Tyr Lys
                325                 330                 335     
Leu Val Glu Val Glu Trp Glu Glu His Leu Ala Arg Asn Pro Pro Thr
            340                 345                 350         
Asp
    


<210> 8127
<211> 548
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 218, 220, 295, 468
<223> Xaa = Any Amino Acid

<400> 8127
Met Glu Val Arg Ala Glu Glu Pro Lys Glu Ala Thr Glu Val Lys Asp
 1               5                  10                  15      
Gln Val Glu Thr Gln Gly Gln Glu Asp Asn Lys Thr Gly Pro Cys Ser
            20                  25                  30          
Asn Gly Lys Ala Ala Ser Thr Ser Arg Pro Leu Glu Thr Gln Gly Asn
        35                  40                  45              
Leu Thr Ser Ser Trp Tyr Asn Pro Arg Pro Leu Glu Gly Asn Val His
    50                  55                  60                  
Leu Lys Ser Leu Thr Glu Lys Asn Gln Thr Asp Lys Ala Gln Val His
65                  70                  75                  80  
Ala Val Ser Phe Tyr Ser Lys Gly His Gly Val Thr Ser Ser His Ser
                85                  90                  95      
Pro Ala Gly Gly Ile Leu Pro Phe Gly Lys Pro Asp Pro Leu Pro Ala
            100                 105                 110         
Val Leu Pro Ala Pro Val Pro Asp Cys Ser Leu Trp Pro Glu Lys Ala
        115                 120                 125             
Ala Leu Lys Val Leu Gly Lys Asp His Leu Pro Ser Ser Pro Gly Leu
    130                 135                 140                 
Leu Met Val Gly Glu Asp Met Gln Pro Lys Asp Pro Ala Ala Leu Arg
145                 150                 155                 160 
Ser Ser Arg Ser Ser Pro Pro Arg Ala Ala Gly His Arg Pro Arg Lys
                165                 170                 175     
Arg Lys Leu Ser Gly Pro Pro Leu Gln Leu Gln Gln Thr Pro Pro Leu
            180                 185                 190         
Gln Leu Arg Ser Thr Leu Leu Leu Asn Leu Asp Leu Val Asp Ser Pro
        195                 200                 205             
Pro Lys Lys Thr Leu Glu Gly Asp Ala Xaa His Xaa Asn Phe Val Lys
    210                 215                 220                 
Lys Trp Arg Leu Leu Glu Trp Arg Asp Phe Leu Ser Lys Lys Lys Gln
225                 230                 235                 240 
Pro Pro Cys Lys Ser Pro Lys Leu His Ser Glu Pro Pro Glu Lys Gly
                245                 250                 255     
Glu Thr Pro Arg Val Asp Gly Thr Trp Lys Thr Pro Pro Phe Leu Lys
            260                 265                 270         
Lys Lys Lys Ile Thr Ala Ser Ser Asn Gly Ser Gly Gln Ser Leu Asp
        275                 280                 285             
Lys Lys Ala Ala Val Phe Xaa Leu Ile Pro Ala Tyr Leu Lys Lys Ala
    290                 295                 300                 
Asp Ser Val Ala Ala Lys Leu Asp Leu Leu Gly Glu Ile Trp Ser Ala
305                 310                 315                 320 
Leu Pro Lys Ile Asn Ser His Pro Thr His Ser Gln Lys Lys Gly Ser
                325                 330                 335     
Arg Lys Lys Ser Ser Lys Lys Asn His Pro Gln Lys Asn Ala Pro Gln
            340                 345                 350         
Asn Ser Thr Gln Ala His Ser Glu Asn Lys Cys Ser Arg Ala Ser Gln
        355                 360                 365             
Lys Leu Pro Arg Lys Met Met Val Ala Ile Asp Ser Glu Met Val Gly
    370                 375                 380                 
Thr Gly Pro Lys Gly His Val Ser Phe Leu Ala Gln Cys Ser Ile Val
385                 390                 395                 400 
Asn Tyr Asn Gly Asp Val Leu Tyr Asp Glu Tyr Ile Leu Pro Pro Cys
                405                 410                 415     
His Thr Val Asp Tyr Trp Thr Arg Trp Ser Gly Ile Gln Lys Gln His
            420                 425                 430         
Met Val Asn Ala Thr Pro Phe Lys Ile Ala Arg Gly Gln Ile Leu Lys
        435                 440                 445             
Ile Leu Thr Gly Lys Ile Val Val Gly His Ala Ile His Asp Asp Leu
    450                 455                 460                 
Lys Ala Leu Xaa Tyr Phe His Pro Lys Ser Leu Thr His Asp Thr Thr
465                 470                 475                 480 
His Ile Pro Thr Ser Ser Thr Gly Met Ser His Ile Pro Arg His Asp
                485                 490                 495     
His Pro Glu Asn Ala Thr Met Ser Leu Lys His Leu Ser Lys Lys Leu
            500                 505                 510         
Leu Asn Trp Asp Ile Gln Val Arg Lys Ser Gly Tyr Ser Ser Val Glu
        515                 520                 525             
Asn Ala Gln Ala Thr Arg Glu Leu Tyr Lys Leu Gly Glu Val Gln Asn
    530                 535                 540                 
Pro Pro Lys Asp
545             


<210> 8128
<211> 454
<212> PRT
<213> Homo sapiens

<400> 8128
Met Cys Ala Ala Gln Met Pro Pro Leu Ala His Ile Phe Arg Gly Thr
 1               5                  10                  15      
Phe Val His Ser Thr Trp Thr Cys Pro Met Glu Val Leu Arg Asp His
            20                  25                  30          
Leu Leu Gly Val Ser Asp Ser Gly Lys Ile Val Phe Leu Glu Glu Ala
        35                  40                  45              
Ser Gln Gln Glu Lys Leu Ala Lys Glu Trp Cys Phe Lys Pro Cys Glu
    50                  55                  60                  
Ile Arg Glu Leu Ser His His Glu Phe Phe Met Pro Gly Leu Val Asp
65                  70                  75                  80  
Thr His Ile His Ala Ser Gln Tyr Ser Phe Ala Gly Ser Ser Ile Asp
                85                  90                  95      
Leu Pro Leu Leu Glu Trp Leu Thr Lys Tyr Thr Phe Pro Ala Glu His
            100                 105                 110         
Arg Phe Gln Asn Ile Asp Phe Ala Glu Glu Val Tyr Thr Arg Val Val
        115                 120                 125             
Arg Arg Thr Leu Lys Asn Gly Thr Thr Thr Ala Cys Tyr Phe Ala Thr
    130                 135                 140                 
Ile His Thr Asp Ser Ser Leu Leu Leu Ala Asp Ile Thr Asp Lys Phe
145                 150                 155                 160 
Gly Gln Arg Ala Phe Val Gly Lys Val Cys Met Asp Leu Asn Asp Thr
                165                 170                 175     
Phe Pro Glu Tyr Lys Glu Thr Thr Glu Glu Ser Ile Lys Glu Thr Glu
            180                 185                 190         
Arg Phe Val Ser Glu Met Leu Gln Lys Asn Tyr Ser Arg Val Lys Pro
        195                 200                 205             
Ile Val Thr Pro Arg Phe Ser Leu Ser Cys Ser Glu Thr Leu Met Gly
    210                 215                 220                 
Glu Leu Gly Asn Ile Ala Lys Thr Arg Asp Leu His Ile Gln Ser His
225                 230                 235                 240 
Ile Ser Glu Asn Arg Asp Glu Val Glu Ala Val Lys Asn Leu Tyr Pro
                245                 250                 255     
Ser Tyr Lys Asn Tyr Thr Ser Val Tyr Asp Lys Asn Asn Leu Leu Thr
            260                 265                 270         
Asn Lys Thr Val Met Ala His Gly Cys Tyr Leu Ser Ala Glu Glu Leu
        275                 280                 285             
Asn Val Phe His Glu Arg Gly Ala Ser Ile Ala His Cys Pro Asn Ser
    290                 295                 300                 
Asn Leu Ser Leu Ser Ser Gly Phe Leu Asn Val Leu Glu Val Leu Lys
305                 310                 315                 320 
His Glu Val Lys Ile Gly Leu Gly Thr Asp Val Ala Gly Gly Tyr Ser
                325                 330                 335     
Tyr Ser Met Leu Asp Ala Ile Arg Arg Ala Val Met Val Ser Asn Ile
            340                 345                 350         
Leu Leu Ile Asn Lys Val Asn Glu Lys Ser Leu Thr Leu Lys Glu Val
        355                 360                 365             
Phe Arg Leu Ala Thr Leu Gly Gly Ser Gln Ala Leu Gly Leu Asp Gly
    370                 375                 380                 
Glu Ile Gly Asn Phe Glu Val Gly Lys Glu Phe Asp Ala Ile Leu Ile
385                 390                 395                 400 
Asn Pro Lys Ala Ser Asp Ser Pro Ile Asp Leu Phe Tyr Gly Asp Phe
                405                 410                 415     
Phe Gly Asp Ile Ser Glu Ala Val Ile Gln Lys Phe Leu Tyr Leu Gly
            420                 425                 430         
Asp Asp Arg Asn Ile Glu Glu Val Tyr Val Gly Gly Lys Gln Val Val
        435                 440                 445             
Pro Phe Ser Ser Ser Val
    450                 


<210> 8129
<211> 862
<212> PRT
<213> Homo sapiens

<400> 8129
Met Glu Arg Ala Glu Ser Ser Ser Thr Glu Pro Ala Lys Ala Ile Lys
 1               5                  10                  15      
Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser Gly Gln Val Val
            20                  25                  30          
Leu Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp
        35                  40                  45              
Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp
    50                  55                  60                  
Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe
65                  70                  75                  80  
Glu Gly Leu Thr Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala
                85                  90                  95      
Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu Ser
            100                 105                 110         
Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His Ala Ser
        115                 120                 125             
Ala Lys Val Gly Thr Arg Leu Met Phe Asp His Asn Gly Lys Ile Ile
    130                 135                 140                 
Gln Lys Thr Pro Tyr Pro Arg Pro Arg Gly Thr Thr Val Ser Val Gln
145                 150                 155                 160 
Gln Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe Gln Arg Asn
                165                 170                 175     
Ile Lys Lys Glu Tyr Ala Lys Met Val Gln Val Leu His Ala Tyr Cys
            180                 185                 190         
Ile Ile Ser Ala Gly Ile Arg Val Ser Cys Thr Asn Gln Leu Gly Gln
        195                 200                 205             
Gly Lys Arg Gln Pro Val Val Cys Thr Gly Gly Ser Pro Ser Ile Lys
    210                 215                 220                 
Glu Asn Ile Gly Ser Val Phe Gly Gln Lys Gln Leu Gln Ser Leu Ile
225                 230                 235                 240 
Pro Phe Val Gln Leu Pro Pro Ser Asp Ser Val Cys Glu Glu Tyr Gly
                245                 250                 255     
Leu Ser Cys Ser Asp Ala Leu His Asn Leu Phe Tyr Ile Ser Gly Phe
            260                 265                 270         
Ile Ser Gln Cys Thr His Gly Val Gly Arg Ser Ser Thr Asp Arg Gln
        275                 280                 285             
Phe Phe Phe Ile Asn Arg Arg Pro Cys Asp Pro Ala Lys Val Cys Arg
    290                 295                 300                 
Leu Val Asn Glu Val Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe
305                 310                 315                 320 
Val Val Leu Asn Ile Ser Val Asp Ser Glu Cys Val Asp Ile Asn Val
                325                 330                 335     
Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu Glu Lys Leu Leu Leu
            340                 345                 350         
Ala Val Leu Lys Thr Ser Leu Ile Gly Met Phe Asp Ser Asp Val Asn
        355                 360                 365             
Lys Leu Asn Val Ser Gln Gln Pro Leu Leu Asp Val Glu Gly Asn Leu
    370                 375                 380                 
Ile Lys Met His Ala Ala Asp Leu Glu Lys Pro Met Val Glu Lys Gln
385                 390                 395                 400 
Asp Gln Ser Pro Ser Leu Arg Thr Gly Glu Glu Lys Lys Asp Val Ser
                405                 410                 415     
Ile Ser Arg Leu Arg Glu Ala Phe Ser Leu Arg His Thr Thr Glu Asn
            420                 425                 430         
Lys Pro His Ser Pro Lys Thr Pro Glu Pro Arg Arg Ser Pro Leu Gly
        435                 440                 445             
Gln Lys Arg Gly Met Leu Ser Ser Ser Thr Ser Gly Ala Ile Ser Asp
    450                 455                 460                 
Lys Gly Val Leu Arg Pro Gln Lys Glu Ala Val Ser Ser Ser His Gly
465                 470                 475                 480 
Pro Ser Asp Pro Thr Asp Arg Ala Glu Val Glu Lys Asp Ser Gly His
                485                 490                 495     
Gly Ser Thr Ser Val Asp Ser Glu Gly Phe Ser Ile Pro Asp Thr Gly
            500                 505                 510         
Ser His Cys Ser Ser Glu Tyr Ala Ala Ser Ser Pro Gly Asp Arg Gly
        515                 520                 525             
Ser Gln Glu His Val Asp Ser Gln Glu Lys Ala Pro Glu Thr Asp Asp
    530                 535                 540                 
Ser Phe Ser Asp Val Asp Cys His Ser Asn Gln Glu Asp Thr Gly Cys
545                 550                 555                 560 
Lys Phe Arg Val Leu Pro Gln Pro Thr Asn Leu Ala Thr Pro Asn Thr
                565                 570                 575     
Lys Arg Phe Lys Lys Glu Glu Ile Leu Ser Ser Ser Asp Ile Cys Gln
            580                 585                 590         
Lys Leu Val Asn Thr Gln Asp Met Ser Ala Ser Gln Val Asp Val Ala
        595                 600                 605             
Val Lys Ile Asn Lys Lys Val Val Pro Leu Asp Phe Ser Met Ser Ser
    610                 615                 620                 
Leu Ala Lys Arg Ile Lys Gln Leu His His Glu Ala Gln Gln Ser Glu
625                 630                 635                 640 
Gly Glu Gln Asn Tyr Arg Lys Phe Arg Ala Lys Ile Cys Pro Gly Glu
                645                 650                 655     
Asn Gln Ala Ala Glu Asp Glu Leu Arg Lys Glu Ile Ser Lys Thr Met
            660                 665                 670         
Phe Ala Glu Met Glu Ile Ile Gly Gln Phe Asn Leu Gly Phe Ile Ile
        675                 680                 685             
Thr Lys Leu Asn Glu Asp Ile Phe Ile Val Asp Gln His Ala Thr Asp
    690                 695                 700                 
Glu Lys Tyr Asn Phe Glu Met Leu Gln Gln His Thr Val Leu Gln Gly
705                 710                 715                 720 
Gln Arg Leu Ile Ala Pro Gln Thr Leu Asn Leu Thr Ala Val Asn Glu
                725                 730                 735     
Ala Val Leu Ile Glu Asn Leu Glu Ile Phe Arg Lys Asn Gly Phe Asp
            740                 745                 750         
Phe Val Ile Asp Glu Asn Ala Pro Val Thr Glu Arg Ala Lys Leu Ile
        755                 760                 765             
Ser Leu Pro Thr Ser Lys Asn Trp Thr Phe Gly Pro Gln Asp Val Asp
    770                 775                 780                 
Glu Leu Ile Phe Met Leu Ser Asp Ser Pro Gly Val Met Cys Arg Pro
785                 790                 795                 800 
Ser Arg Val Lys Gln Met Phe Ala Ser Arg Ala Cys Arg Lys Ser Val
                805                 810                 815     
Met Ile Gly Thr Ala Leu Asn Thr Ser Glu Met Lys Lys Leu Ile Thr
            820                 825                 830         
His Met Gly Glu Met Asp His Pro Trp Asn Cys Pro His Gly Arg Pro
        835                 840                 845             
Thr Met Arg His Ile Ala Asn Leu Gly Val Ile Ser Gln Asn
    850                 855                 860         


<210> 8130
<211> 1564
<212> PRT
<213> Homo sapiens

<400> 8130
Ala Glu Met Ala Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly
 1               5                  10                  15      
Pro Gly Pro Gly Pro Gly Gly Gly Gly Gly Pro Ser Gly Ser Gly Ser
            20                  25                  30          
Gly Pro Gly Ser Asn Gly Gly Leu Gly Ser Gly Gly Glu Leu His Pro
        35                  40                  45              
Arg Thr Gly Arg Leu Val Ser Leu Ser Ala Cys Gly Arg Thr Ala Arg
    50                  55                  60                  
Arg Gln Gln Pro Gly Gln Glu Phe Asn His Gly Leu Val Leu Ser Arg
65                  70                  75                  80  
Glu Pro Leu Arg Asp Gly Arg Val Phe Thr Val Arg Ile Asp Arg Lys
                85                  90                  95      
Val Asn Ser Trp Ser Gly Ser Ile Glu Ile Gly Val Thr Ala Leu Asp
            100                 105                 110         
Pro Ser Val Leu Asp Phe Pro Ser Ser Ala Thr Gly Leu Lys Gly Gly
        115                 120                 125             
Ser Trp Val Val Ser Gly Cys Ser Val Leu Arg Asp Gly Arg Ser Val
    130                 135                 140                 
Leu Glu Glu Tyr Gly Gln Asp Leu Asp Gln Leu Gly Glu Gly Asp Arg
145                 150                 155                 160 
Val Gly Val Glu Arg Thr Val Ala Gly Glu Leu Arg Leu Trp Val Asn
                165                 170                 175     
Gly Arg Asp Cys Gly Val Ala Ala Thr Gly Leu Pro Pro Arg Val Trp
            180                 185                 190         
Ala Val Val Asp Leu Tyr Gly Lys Cys Thr Gln Ile Thr Val Leu Pro
        195                 200                 205             
Pro Glu Pro Gly Phe Ser Pro Pro Thr Pro Ile Pro Thr Pro Pro Leu
    210                 215                 220                 
Glu Pro Leu Ala Pro Thr Glu Asp Ser Ala Leu Ala Glu Gln Gly Thr
225                 230                 235                 240 
Ser Ala Asp Glu Ala Phe Met Val Ser Pro Ala Gln Ala Arg Pro Glu
                245                 250                 255     
Thr Phe Pro Asn Ser Leu Glu Ser His Asn Asp Phe Ala Asn Met Glu
            260                 265                 270         
Leu Ser Glu Val Val Ser Asn Thr Ile Leu Ser Ala Tyr Asn Gly Gly
        275                 280                 285             
Leu Leu Asn Val Asn Leu Ser Ser Pro Pro Ala Gly Glu Gly Leu Gly
    290                 295                 300                 
Ser Ser Gly Ala Ala Thr Ser Pro Ile Leu Thr Ser Asn Asp Ala Leu
305                 310                 315                 320 
Leu Phe His Glu Lys Cys Gly Thr Leu Ile Lys Leu Ser Asn Asn Asn
                325                 330                 335     
Lys Thr Ala Glu Arg Arg Arg Pro Leu Asp Glu Phe Asn Asn Gly Val
            340                 345                 350         
Val Met Thr Asn Arg Pro Leu Arg Asp Asn Glu Met Phe Glu Ile Arg
        355                 360                 365             
Ile Asp Lys Leu Val Asp Lys Trp Ser Gly Ser Ile Glu Ile Gly Val
    370                 375                 380                 
Thr Thr His Asn Pro Asn Ser Leu Glu Tyr Pro Ala Thr Met Thr Asn
385                 390                 395                 400 
Leu Gln Ser Gly Thr Ile Met Met Ser Gly Cys Gly Ile Leu Thr Asn
                405                 410                 415     
Gly Lys Gly Thr Arg Arg Glu Tyr Cys Glu Phe Ser Leu Asp Glu Leu
            420                 425                 430         
Gln Glu Gly Asp His Ile Gly Leu Thr Arg Lys Ser Asn Ser Ala Leu
        435                 440                 445             
His Phe Phe Ile Asn Gly Ile Asp Gln Gly Val Ala Thr Pro Leu Thr
    450                 455                 460                 
Pro Pro Val Val Tyr Gly Val Val Asp Leu Tyr Gly Met Ala Val Lys
465                 470                 475                 480 
Val Thr Ile Val His Asn Asn Asn His Ser Asp Arg Leu Arg Arg Asn
                485                 490                 495     
Asn Ala Ile Leu Arg Ala Leu Ser Pro Glu Gly Ala Leu Arg Arg Ala
            500                 505                 510         
Ala Pro Ala Ala Gln Ala Glu Pro Glu Arg Leu Leu Phe His Pro Asn
        515                 520                 525             
Cys Gly Gln Lys Ala Ala Ile Thr His Glu Gly Arg Thr Ala Leu Arg
    530                 535                 540                 
Pro His Ala Thr Asp Asp Phe Asn His Gly Val Val Leu Ser Ser Arg
545                 550                 555                 560 
Ala Leu Arg Asp Gly Glu Val Phe Gln Val Arg Ile Asp Lys Met Val
                565                 570                 575     
Asp Lys Trp Ala Gly Ser Ile Glu Ile Gly Val Thr Thr His Asn Pro
            580                 585                 590         
Ala Tyr Leu Gln Leu Pro Ser Thr Met Thr Asn Leu Arg Ser Gly Thr
        595                 600                 605             
Trp Met Met Thr Gly Asn Gly Val Met His Asn Gly Thr Thr Ile Leu
    610                 615                 620                 
Asp Glu Tyr Gly His Asn Leu Asp Arg Leu Lys Ala Gly Asp Thr Val
625                 630                 635                 640 
Gly Val Val Arg Arg Glu Asp Gly Thr Leu His Phe Phe Val Asn Gly
                645                 650                 655     
Met Thr Gln Gly Pro Ala Ala Trp Asn Val Pro Pro Gly Val Tyr Ala
            660                 665                 670         
Val Val Asp Leu Tyr Gly Gln Ala Ala Gln Ala Thr Ile Val Asp Asp
        675                 680                 685             
Val Glu Val Ala Pro Val Pro Glu Pro Leu Pro Glu Gly Asn Asn Gln
    690                 695                 700                 
Val Ser Pro Ser Ser Pro Ser Ser Gly Ala Gly Gly Ser Asp Leu Arg
705                 710                 715                 720 
Phe His Gln Leu His Gly Ser Asn Ala Val Ile Thr Asn Gly Gly Arg
                725                 730                 735     
Thr Ala Leu Arg His Asn Cys Arg Ser Glu Phe Asn Asp Ala Ile Val
            740                 745                 750         
Ile Ser Asn Arg Ala Leu Arg Asp Gly Glu Leu Phe Glu Ile Val Ile
        755                 760                 765             
Gln Lys Met Val Asp Arg Trp Ser Gly Ser Ile Glu Ala Gly Val Thr
    770                 775                 780                 
Ala Ile Arg Pro Glu Asp Leu Glu Phe Pro Asn Thr Met Thr Asp Ile
785                 790                 795                 800 
Asp Tyr Asp Thr Trp Met Leu Ser Gly Thr Ala Ile Met Gln Asp Gly
                805                 810                 815     
Asn Thr Met Arg Asn Asn Tyr Gly Cys Asp Leu Asp Ala Leu Gly Thr
            820                 825                 830         
Gly Ala Arg Ile Gly Met Met Arg Thr Ala Lys Gly Asp Leu His Tyr
        835                 840                 845             
Phe Ile Asn Gly Gln Asp Gln Gly Ala Ala Cys Ser Gly Leu Pro Pro
    850                 855                 860                 
Gly Lys Glu Val Tyr Ala Val Val Asp Leu Tyr Gly Gln Cys Val Gln
865                 870                 875                 880 
Val Ser Ile Thr Asn Ala Thr Gly Pro Met Asp Asn Ser Leu Ala Thr
                885                 890                 895     
Ser Asn Thr Ala Thr Glu Lys Ser Phe Pro Leu His Ser Pro Val Ala
            900                 905                 910         
Gly Val Ala His Arg Phe His Ser Thr Cys Gly Lys Asn Val Thr Leu
        915                 920                 925             
Glu Glu Asp Gly Thr Arg Ala Val Arg Ala Ala Gly Tyr Ala His Gly
    930                 935                 940                 
Leu Val Phe Ser Thr Lys Glu Leu Arg Ala Glu Glu Val Phe Glu Val
945                 950                 955                 960 
Lys Val Glu Glu Leu Asp Glu Lys Trp Ala Gly Ser Leu Arg Leu Gly
                965                 970                 975     
Leu Thr Thr Leu Ala Pro Gly Glu Met Gly Pro Gly Ala Gly Gly Gly
            980                 985                 990         
Gly Pro Gly Leu Pro Pro Ser Leu Pro Glu Leu Arg Thr Lys Thr Thr
        995                 1000                1005            
Trp Met Val Ser Ser Cys Glu Val Arg Arg Asp Gly Gln Leu Gln Arg
    1010                1015                1020                
Met Asn Tyr Gly Arg Asn Leu Glu Arg Leu Gly Val Gly Ser Arg Val
1025                1030                1035                1040
Gly Val Arg Arg Gly Ala Asp Asp Thr Met His Ile Leu Val Asp Gly
                1045                1050                1055    
Glu Asp Met Gly Pro Ala Ala Thr Gly Ile Ala Lys Asn Val Trp Ala
            1060                1065                1070        
Val Leu Asp Leu Tyr Gly Pro Val Arg Gly Val Ser Ile Val Ser Ser
        1075                1080                1085            
Thr Arg Leu Glu Glu Ser Glu Gly Thr Gln Pro Pro Ser Pro Ser Ser
    1090                1095                1100                
Asp Thr Gly Ser Glu Gly Glu Glu Asp Asp Glu Gly Glu Glu His Gly
1105                1110                1115                1120
Leu Gly Gly Gln Asn Glu Val Gly Ile Ile Pro Thr Thr Leu Glu Phe
                1125                1130                1135    
Leu Glu Asn His Gly Lys Asn Ile Leu Leu Ser Asn Gly Asn Arg Thr
            1140                1145                1150        
Ala Thr Arg Val Ala Ser Tyr Asn Gln Gly Ile Val Val Ile Asn Gln
        1155                1160                1165            
Pro Leu Val Pro Gln Leu Leu Val Gln Val Arg Ile Asp Phe Leu Asn
    1170                1175                1180                
Arg Gln Trp Thr Ser Ser Leu Val Leu Gly Val Ile Thr Cys Ala Pro
1185                1190                1195                1200
Glu Arg Leu Asn Phe Pro Ala Ser Ala Cys Ala Leu Lys Arg Ala Ala
                1205                1210                1215    
Trp Leu Leu Arg Gly Arg Gly Val Phe His Asn Gly Leu Lys Ile Cys
            1220                1225                1230        
Glu Lys Phe Gly Pro Asn Leu Asp Thr Cys Pro Glu Gly Thr Ile Leu
        1235                1240                1245            
Gly Leu Arg Leu Asp Ser Ser Gly Gly Leu His Leu His Val Asn Gly
    1250                1255                1260                
Val Asp Gln Gly Val Ala Val Pro Asp Val Pro Gln Pro Cys His Ala
1265                1270                1275                1280
Leu Val Asp Leu Tyr Gly Gln Cys Glu Gln Val Thr Ile Val Asn Pro
                1285                1290                1295    
Glu Pro Gly Ala Ala Ser Gly Lys Ser Ala Gly Thr Gln Gly Asp Met
            1300                1305                1310        
Glu Lys Ala Asp Met Val Asp Gly Ile Lys Glu Ser Val Cys Trp Gly
        1315                1320                1325            
Pro Pro Pro Ala Ala Ser Pro Leu Lys Ser Cys Glu Tyr His Ala Leu
    1330                1335                1340                
Cys Ser Arg Phe Gln Glu Leu Leu Leu Leu Pro Glu Asp Tyr Phe Met
1345                1350                1355                1360
Pro Pro Pro Lys Arg Ser Leu Cys Tyr Cys Glu Ser Cys Arg Lys Leu
                1365                1370                1375    
Arg Gly Asp Glu Ala His Arg Arg Arg Gly Glu Pro Pro Arg Glu Tyr
            1380                1385                1390        
Ala Leu Pro Phe Gly Trp Cys Arg Phe Asn Leu Arg Val Asn Pro Arg
        1395                1400                1405            
Leu Glu Ala Gly Thr Leu Thr Lys Lys Trp His Met Ala Tyr His Gly
    1410                1415                1420                
Ser Asn Val Ala Ala Val Arg Arg Val Leu Asp Arg Gly Glu Leu Gly
1425                1430                1435                1440
Ala Gly Thr Ala Ser Ile Leu Ser Cys Arg Pro Leu Lys Gly Glu Pro
                1445                1450                1455    
Gly Val Gly Phe Glu Glu Pro Gly Glu Asn Cys Ala Pro Pro Arg Glu
            1460                1465                1470        
Glu Gln Pro Pro Pro Val Leu Leu Ser Pro Ser Leu Gln Tyr Ala Gly
        1475                1480                1485            
Ala Glu Thr Leu Ala Ser Lys Val Gln Phe Arg Asp Pro Lys Ser Gln
    1490                1495                1500                
Arg Thr His Gln Ala Gln Val Ala Phe Gln Val Cys Val Arg Pro Gly
1505                1510                1515                1520
Ser Tyr Thr Pro Gly Pro Pro Ser Ala Ala Leu Gly Glu Pro Pro Asp
                1525                1530                1535    
Pro His Phe Ser Pro Ala Glu Leu Glu Trp Val Thr Lys Glu Lys Gly
            1540                1545                1550        
Ala Thr Leu Leu Cys Ala Leu Leu Val Arg Val Glu
        1555                1560                


<210> 8131
<211> 1743
<212> PRT
<213> Homo sapiens

<400> 8131
Met Ala Thr Asp Ser Gly Asp Pro Ala Ser Thr Glu Asp Ser Glu Lys
 1               5                  10                  15      
Pro Asp Gly Ile Ser Phe Glu Asn Arg Val Pro Gln Val Ala Ala Thr
            20                  25                  30          
Leu Thr Val Glu Ala Arg Leu Lys Glu Lys Asn Ser Thr Phe Ser Ala
        35                  40                  45              
Ser Gly Glu Thr Val Glu Arg Lys Arg Phe Phe Arg Lys Ser Val Glu
    50                  55                  60                  
Met Thr Glu Asp Asp Lys Val Ala Glu Ser Ser Pro Lys Asp Glu Arg
65                  70                  75                  80  
Ile Lys Ala Ala Met Asn Ile Pro Arg Val Asp Lys Leu Pro Ser Asn
                85                  90                  95      
Val Leu Arg Gly Gly Gln Glu Val Lys Tyr Glu Gln Cys Ser Lys Ser
            100                 105                 110         
Thr Ser Glu Ile Ser Lys Asp Cys Phe Lys Glu Lys Asn Glu Lys Glu
        115                 120                 125             
Met Glu Glu Glu Ala Glu Met Lys Ala Val Ala Thr Ser Pro Ser Gly
    130                 135                 140                 
Arg Phe Leu Lys Phe Asp Ile Glu Leu Gly Arg Gly Ala Phe Lys Thr
145                 150                 155                 160 
Val Tyr Lys Gly Leu Asp Thr Glu Thr Trp Val Glu Val Ala Trp Cys
                165                 170                 175     
Glu Leu Gln Asp Arg Lys Leu Thr Lys Ala Glu Gln Gln Arg Phe Lys
            180                 185                 190         
Glu Glu Ala Glu Met Leu Lys Gly Leu Gln His Pro Asn Ile Val Arg
        195                 200                 205             
Phe Tyr Asp Ser Trp Glu Ser Ile Leu Lys Gly Lys Lys Cys Ile Val
    210                 215                 220                 
Leu Val Thr Glu Leu Met Thr Ser Gly Thr Leu Lys Thr Tyr Leu Lys
225                 230                 235                 240 
Arg Phe Lys Val Met Lys Pro Lys Val Leu Arg Ser Trp Cys Arg Gln
                245                 250                 255     
Ile Leu Lys Gly Leu Gln Phe Leu His Thr Arg Thr Pro Pro Ile Ile
            260                 265                 270         
His Arg Asp Leu Lys Cys Asp Asn Ile Phe Ile Thr Gly Pro Thr Gly
        275                 280                 285             
Ser Val Lys Ile Gly Asp Leu Gly Leu Ala Thr Leu Met Arg Thr Ser
    290                 295                 300                 
Phe Ala Lys Ser Val Ile Gly Thr Pro Glu Phe Met Ala Pro Glu Met
305                 310                 315                 320 
Tyr Glu Glu His Tyr Asp Glu Ser Val Asp Val Tyr Ala Phe Gly Met
                325                 330                 335     
Cys Met Leu Glu Met Ala Thr Ser Glu Tyr Pro Tyr Ser Glu Cys Gln
            340                 345                 350         
Asn Ala Ala Gln Ile Tyr Arg Lys Val Thr Ser Gly Ile Lys Pro Ala
        355                 360                 365             
Ser Phe Asn Lys Val Thr Asp Pro Glu Val Lys Glu Ile Ile Glu Gly
    370                 375                 380                 
Cys Ile Arg Gln Asn Lys Ser Glu Arg Leu Ser Ile Arg Asp Leu Leu
385                 390                 395                 400 
Asn His Ala Phe Phe Ala Glu Asp Thr Gly Leu Arg Val Glu Leu Ala
                405                 410                 415     
Glu Glu Asp Asp Cys Ser Asn Ser Ser Leu Ala Leu Arg Leu Trp Val
            420                 425                 430         
Glu Asp Pro Lys Lys Leu Lys Gly Lys His Lys Asp Asn Glu Ala Ile
        435                 440                 445             
Glu Phe Ser Phe Asn Leu Glu Thr Asp Thr Pro Glu Glu Val Ala Tyr
    450                 455                 460                 
Glu Met Val Lys Ser Gly Phe Phe His Glu Ser Asp Ser Lys Ala Val
465                 470                 475                 480 
Ala Lys Ser Ile Arg Asp Arg Val Thr Pro Ile Lys Lys Thr Arg Glu
                485                 490                 495     
Lys Lys Pro Ala Gly Cys Leu Glu Glu Arg Arg Asp Ser Gln Cys Lys
            500                 505                 510         
Ser Met Gly Asn Val Phe Pro Gln Pro Gln Asn Thr Thr Leu Pro Leu
        515                 520                 525             
Ala Pro Ala Gln Gln Thr Gly Ala Glu Cys Glu Glu Thr Glu Val Asp
    530                 535                 540                 
Gln His Val Arg Gln Gln Leu Leu Gln Arg Lys Pro Gln Gln His Cys
545                 550                 555                 560 
Ser Ser Val Thr Gly Asp Asn Leu Ser Glu Ala Gly Ala Ala Ser Val
                565                 570                 575     
Ile His Ser Asp Thr Ser Ser Gln Pro Ser Val Ala Tyr Ser Ser Asn
            580                 585                 590         
Gln Thr Met Gly Ser Gln Met Val Ser Asn Ile Pro Gln Ala Glu Val
        595                 600                 605             
Asn Val Pro Gly Gln Ile Tyr Ser Ser Gln Gln Leu Val Gly His Tyr
    610                 615                 620                 
Gln Gln Val Ser Gly Leu Gln Lys His Ser Lys Leu Thr Gln Pro Gln
625                 630                 635                 640 
Ile Leu Pro Leu Val Gln Gly Gln Ser Thr Val Leu Pro Val His Val
                645                 650                 655     
Leu Gly Pro Thr Val Val Ser Gln Pro Gln Val Ser Pro Leu Thr Val
            660                 665                 670         
Gln Lys Val Pro Gln Ile Lys Pro Val Ser Gln Pro Val Gly Ala Glu
        675                 680                 685             
Gln Gln Ala Ala Leu Leu Lys Pro Asp Leu Val Arg Ser Leu Asn Gln
    690                 695                 700                 
Asp Val Ala Thr Thr Lys Glu Asn Val Ser Ser Pro Asp Asn Pro Ser
705                 710                 715                 720 
Gly Asn Gly Lys Gln Asp Arg Ile Lys Gln Arg Arg Ala Ser Cys Pro
                725                 730                 735     
Arg Pro Glu Lys Gly Thr Lys Phe Gln Leu Thr Val Leu Gln Val Ser
            740                 745                 750         
Thr Ser Gly Asp Asn Met Val Glu Cys Gln Leu Glu Thr His Asn Asn
        755                 760                 765             
Lys Met Val Thr Phe Lys Phe Asp Val Asp Gly Asp Ala Pro Glu Asp
    770                 775                 780                 
Ile Ala Asp Tyr Met Val Glu Asp Asn Phe Val Leu Glu Ser Glu Lys
785                 790                 795                 800 
Glu Lys Phe Val Glu Glu Leu Arg Ala Ile Val Gly Gln Ala Gln Glu
                805                 810                 815     
Ile Leu His Val His Phe Ala Thr Glu Arg Ala Thr Gly Val Asp Ser
            820                 825                 830         
Ile Thr Val Asp Ser Asn Ser Ser Gln Thr Gly Ser Ser Glu Gln Val
        835                 840                 845             
Gln Ile Asn Ser Thr Ser Thr Gln Thr Ser Asn Glu Ser Ala Pro Gln
    850                 855                 860                 
Ser Ser Pro Val Gly Arg Trp Arg Phe Cys Ile Asn Gln Thr Ile Arg
865                 870                 875                 880 
Asn Arg Glu Thr Gln Ser Pro Pro Ser Leu Gln His Ser Met Ser Ala
                885                 890                 895     
Val Pro Gly Arg His Pro Leu Pro Ser Pro Lys Asn Thr Ser Asn Lys
            900                 905                 910         
Glu Ile Ser Arg Asp Thr Leu Leu Thr Ile Glu Asn Asn Pro Cys His
        915                 920                 925             
Arg Ala Leu Phe Thr Ser Lys Ser Glu His Lys Asp Val Val Asp Gly
    930                 935                 940                 
Lys Ile Ser Glu Cys Ala Ser Val Glu Thr Lys Gln Pro Ala Ile Leu
945                 950                 955                 960 
Tyr Gln Val Glu Asp Asn Arg Gln Ile Met Ala Pro Val Thr Asn Ser
                965                 970                 975     
Ser Ser Tyr Ser Thr Thr Ser Val Arg Ala Val Pro Ala Glu Cys Glu
            980                 985                 990         
Gly Leu Thr Lys Gln Ala Ser Ile Phe Ile Pro Val Tyr Pro Cys His
        995                 1000                1005            
Gln Thr Ala Ser Gln Ala Asp Ala Leu Met Ser His Pro Gly Glu Ser
    1010                1015                1020                
Thr Gln Thr Ser Gly Asn Ser Leu Thr Thr Leu Ala Phe Asp Gln Lys
1025                1030                1035                1040
Pro Gln Thr Leu Ser Val Gln Gln Pro Ala Met Asp Ala Glu Phe Ile
                1045                1050                1055    
Ser Gln Glu Gly Glu Thr Thr Val Asn Thr Glu Ala Ser Ser Pro Lys
            1060                1065                1070        
Thr Val Ile Pro Thr Gln Thr Pro Gly Leu Glu Pro Thr Thr Leu Gln
        1075                1080                1085            
Pro Thr Thr Val Leu Glu Ser Asp Gly Glu Arg Pro Pro Lys Leu Glu
    1090                1095                1100                
Phe Ala Asp Asn Arg Ile Lys Thr Leu Asp Glu Lys Leu Arg Asn Leu
1105                1110                1115                1120
Leu Tyr Gln Glu His Ser Ile Ser Ser Ile Tyr Pro Glu Ser Gln Lys
                1125                1130                1135    
Asp Thr Gln Ser Ile Asp Ser Pro Phe Ser Ser Ser Ala Glu Asp Thr
            1140                1145                1150        
Leu Ser Cys Pro Val Thr Glu Val Ile Ala Ile Ser His Cys Gly Ile
        1155                1160                1165            
Lys Asp Ser Pro Val Gln Ser Pro Asn Phe Gln Gln Thr Gly Ser Lys
    1170                1175                1180                
Leu Leu Ser Asn Val Ala Ala Ser Gln Pro Ala Asn Ile Ser Val Phe
1185                1190                1195                1200
Lys Arg Asp Leu Asn Val Ile Thr Ser Val Pro Ser Glu Leu Cys Leu
                1205                1210                1215    
His Glu Met Ser Ser Asp Ala Ser Leu Pro Gly Asp Pro Glu Ala Tyr
            1220                1225                1230        
Pro Ala Ala Val Ser Ser Gly Gly Ala Ile His Leu Gln Thr Gly Val
        1235                1240                1245            
Glu Thr Glu Glu Met Arg Ser Ala Ile Ala Pro Asp Pro Ile Pro Leu
    1250                1255                1260                
Thr Arg Glu Ser Thr Ala Asp Thr Arg Ala Leu Asn Arg Cys Lys Ala
1265                1270                1275                1280
Met Ser Gly Ser Phe Gln Arg Gly Arg Phe Gln Val Ile Thr Ile Pro
                1285                1290                1295    
Gln Gln Gln Ser Ala Lys Met Thr Ser Phe Gly Ile Glu His Ile Ser
            1300                1305                1310        
Val Phe Ser Glu Thr Asn His Ser Ser Glu Glu Ala Phe Ile Lys Thr
        1315                1320                1325            
Ala Lys Ser Gln Leu Val Glu Ile Glu Pro Ala Thr Gln Asn Pro Lys
    1330                1335                1340                
Thr Ser Phe Ser Tyr Glu Lys Leu Gln Ala Leu Gln Glu Thr Cys Lys
1345                1350                1355                1360
Glu Asn Lys Gly Val Pro Lys Gln Gly Asp Asn Phe Leu Ser Phe Ser
                1365                1370                1375    
Ala Ala Cys Glu Thr Asp Val Ser Ser Val Thr Pro Glu Lys Glu Phe
            1380                1385                1390        
Glu Glu Thr Ser Ala Thr Gly Ser Ser Met Gln Ser Gly Ser Glu Leu
        1395                1400                1405            
Leu Leu Lys Glu Arg Glu Ile Leu Thr Ala Gly Lys Gln Pro Ser Ser
    1410                1415                1420                
Asp Ser Glu Phe Ser Ala Ser Leu Ala Gly Ser Gly Lys Ser Val Ala
1425                1430                1435                1440
Lys Thr Gly Pro Glu Ser Asn Gln Cys Leu Pro His His Glu Glu Gln
                1445                1450                1455    
Ala Tyr Ala Gln Thr Gln Ser Ser Leu Phe Tyr Ser Pro Ser Ser Pro
            1460                1465                1470        
Met Ser Ser Asp Asp Glu Ser Glu Ile Glu Asp Glu Asp Leu Lys Val
        1475                1480                1485            
Glu Leu Gln Arg Leu Arg Glu Lys His Ile Gln Glu Val Val Asn Leu
    1490                1495                1500                
Gln Thr Gln Gln Asn Lys Glu Leu Gln Glu Leu Tyr Glu Arg Leu Arg
1505                1510                1515                1520
Ser Ile Lys Asp Ser Lys Thr Gln Ser Thr Glu Ile Pro Leu Pro Pro
                1525                1530                1535    
Ala Ser Pro Arg Arg Pro Arg Ser Phe Lys Ser Lys Leu Arg Ser Arg
            1540                1545                1550        
Pro Gln Ser Leu Thr His Val Asp Asn Gly Ile Val Ala Thr Asp Pro
        1555                1560                1565            
Leu Cys Val Glu Ser Asn Ala Ala Ser Cys Gln Gln Ser Pro Ala Ser
    1570                1575                1580                
Lys Lys Gly Met Phe Thr Asp Asp Leu His Lys Leu Val Asp Asp Trp
1585                1590                1595                1600
Thr Lys Glu Ala Val Gly Asn Ser Leu Ile Lys Pro Ser Leu Asn Gln
                1605                1610                1615    
Leu Lys Gln Ser Gln His Lys Leu Glu Thr Glu Asn Trp Asn Lys Val
            1620                1625                1630        
Ser Glu Asn Thr Pro Ser Thr Met Gly Tyr Thr Ser Thr Trp Ile Ser
        1635                1640                1645            
Ser Leu Ser Gln Ile Arg Gly Ala Val Pro Thr Ser Leu Pro Gln Gly
    1650                1655                1660                
Leu Ser Leu Pro Ser Phe Pro Gly Pro Leu Ser Ser Tyr Gly Met Pro
1665                1670                1675                1680
His Val Cys Gln Tyr Asn Ala Val Ala Gly Ala Gly Tyr Pro Val Gln
                1685                1690                1695    
Trp Val Gly Ile Ser Gly Thr Thr Gln Gln Ser Val Val Ile Pro Ala
            1700                1705                1710        
Gln Ser Gly Gly Pro Phe Gln Pro Gly Met Asn Met Gln Ala Phe Pro
        1715                1720                1725            
Thr Ser Ser Val Gln Asn Pro Ala Thr Ile Pro Pro Gly Pro Lys
    1730                1735                1740            


<210> 8132
<211> 1800
<212> PRT
<213> Homo sapiens

<400> 8132
Met Ala Thr Asp Ser Gly Asp Pro Ala Asn Thr Glu Asp Ser Glu Lys
 1               5                  10                  15      
Pro Asp Gly Ile Ser Phe Glu Asn Arg Val Pro Gln Val Ala Ala Thr
            20                  25                  30          
Leu Thr Val Glu Ala Arg Leu Lys Glu Lys Asn Ser Thr Phe Ser Ala
        35                  40                  45              
Ser Gly Glu Thr Val Glu Arg Lys Arg Phe Phe Arg Lys Ser Val Glu
    50                  55                  60                  
Met Thr Glu Asp Asp Lys Val Ala Glu Ser Ser Pro Lys Asp Glu Arg
65                  70                  75                  80  
Ile Lys Ala Ala Met Asn Ile Pro Arg Val Asp Lys Leu Pro Ser Asn
                85                  90                  95      
Val Leu Arg Gly Gly Gln Glu Val Lys Tyr Glu Gln Cys Ser Lys Ser
            100                 105                 110         
Thr Ser Glu Ile Ser Lys Asp Cys Phe Lys Glu Lys Asn Glu Lys Glu
        115                 120                 125             
Met Glu Glu Glu Ala Glu Met Lys Ala Val Ala Thr Ser Pro Ser Gly
    130                 135                 140                 
Arg Phe Leu Lys Phe Asp Ile Glu Leu Gly Arg Gly Ala Phe Lys Thr
145                 150                 155                 160 
Val Tyr Lys Gly Leu Asp Thr Glu Thr Trp Val Glu Val Ala Trp Cys
                165                 170                 175     
Glu Leu Gln Asp Arg Lys Leu Thr Lys Ala Glu Gln Gln Arg Phe Lys
            180                 185                 190         
Glu Glu Ala Glu Met Leu Lys Gly Leu Gln His Pro Asn Ile Val Arg
        195                 200                 205             
Phe Tyr Asp Ser Trp Glu Ser Ile Leu Lys Gly Lys Lys Cys Ile Val
    210                 215                 220                 
Leu Val Thr Glu Leu Met Thr Ser Gly Thr Leu Lys Thr Tyr Leu Lys
225                 230                 235                 240 
Arg Phe Lys Val Met Lys Pro Lys Val Leu Arg Ser Trp Cys Arg Gln
                245                 250                 255     
Ile Leu Lys Gly Leu Gln Phe Leu His Thr Arg Thr Pro Pro Ile Ile
            260                 265                 270         
His Arg Asp Leu Lys Cys Asp Asn Ile Phe Ile Thr Gly Pro Thr Gly
        275                 280                 285             
Ser Val Lys Ile Gly Asp Leu Gly Leu Ala Thr Leu Met Arg Thr Ser
    290                 295                 300                 
Phe Ala Lys Ser Val Ile Gly Thr Pro Glu Phe Met Ala Pro Glu Met
305                 310                 315                 320 
Tyr Glu Glu His Tyr Asp Glu Ser Val Asp Val Tyr Ala Phe Gly Met
                325                 330                 335     
Cys Met Leu Glu Met Ala Thr Ser Glu Tyr Pro Tyr Ser Glu Cys Gln
            340                 345                 350         
Asn Ala Ala Gln Ile Tyr Arg Lys Val Thr Ser Gly Ile Lys Pro Ala
        355                 360                 365             
Ser Phe Asn Lys Val Thr Asp Pro Glu Val Lys Glu Ile Ile Glu Gly
    370                 375                 380                 
Cys Ile Arg Gln Asn Lys Ser Glu Arg Leu Ser Ile Arg Asp Leu Leu
385                 390                 395                 400 
Asn His Ala Phe Phe Ala Glu Asp Thr Gly Leu Arg Val Glu Leu Ala
                405                 410                 415     
Glu Glu Asp Asp Cys Ser Asn Ser Ser Leu Ala Leu Arg Leu Trp Val
            420                 425                 430         
Glu Asp Pro Lys Lys Leu Lys Gly Lys His Lys Asp Asn Glu Ala Ile
        435                 440                 445             
Glu Phe Ser Phe Asn Leu Glu Thr Asp Thr Pro Glu Glu Val Ala Tyr
    450                 455                 460                 
Glu Met Val Lys Ser Gly Phe Phe His Glu Ser Asp Ser Lys Ala Val
465                 470                 475                 480 
Ala Lys Ser Ile Arg Asp Arg Val Thr Pro Ile Lys Lys Thr Arg Glu
                485                 490                 495     
Lys Lys Pro Ala Gly Cys Leu Glu Glu Arg Arg Asp Ser Gln Cys Lys
            500                 505                 510         
Ser Met Gly Asn Val Phe Pro Gln Pro Gln Asn Thr Thr Leu Pro Leu
        515                 520                 525             
Ala Pro Ala Gln Gln Thr Gly Ala Glu Cys Glu Glu Thr Glu Val Asp
    530                 535                 540                 
Gln His Val Arg Gln Gln Leu Leu Gln Arg Lys Pro Gln Gln His Cys
545                 550                 555                 560 
Ser Ser Val Thr Gly Asp Asn Leu Ser Glu Ala Gly Ala Ala Ser Val
                565                 570                 575     
Ile His Ser Asp Thr Ser Ser Gln Pro Ser Val Ala Tyr Ser Ser Asn
            580                 585                 590         
Gln Thr Met Gly Ser Gln Met Val Ser Asn Ile Pro Gln Ala Glu Val
        595                 600                 605             
Asn Val Pro Gly Gln Ile Tyr Ser Ser Gln Gln Leu Val Gly His Tyr
    610                 615                 620                 
Gln Gln Val Ser Gly Leu Gln Lys His Ser Lys Leu Thr Gln Pro Gln
625                 630                 635                 640 
Ile Leu Pro Leu Val Gln Gly Gln Ser Thr Val Leu Pro Val His Val
                645                 650                 655     
Leu Gly Pro Thr Val Val Ser Gln Pro Gln Val Ser Pro Leu Thr Val
            660                 665                 670         
Gln Lys Val Pro Gln Ile Lys Pro Val Ser Gln Pro Val Gly Ala Glu
        675                 680                 685             
Gln Gln Ala Ala Leu Leu Lys Pro Asp Leu Val Arg Ser Leu Asn Gln
    690                 695                 700                 
Asp Val Ala Thr Thr Lys Glu Asn Val Ser Ser Pro Asp Asn Pro Ser
705                 710                 715                 720 
Gly Asn Gly Lys Gln Asp Arg Ile Lys Gln Arg Arg Ala Ser Cys Pro
                725                 730                 735     
Arg Pro Glu Lys Gly Thr Lys Phe Gln Leu Thr Val Leu Gln Val Ser
            740                 745                 750         
Thr Ser Gly Asp Asn Met Val Glu Cys Gln Leu Glu Thr His Asn Asn
        755                 760                 765             
Lys Met Val Thr Phe Lys Phe Asp Val Asp Gly Asp Ala Pro Glu Asp
    770                 775                 780                 
Ile Ala Asp Tyr Met Val Glu Asp Asn Phe Val Leu Glu Ser Glu Lys
785                 790                 795                 800 
Glu Lys Phe Val Glu Glu Leu Arg Ala Ile Val Gly Gln Ala Gln Glu
                805                 810                 815     
Ile Leu His Val His Phe Ala Thr Glu Arg Ala Thr Gly Val Asp Ser
            820                 825                 830         
Ile Thr Val Asp Ser Asn Ser Ser Gln Thr Gly Ser Ser Glu Gln Val
        835                 840                 845             
Gln Ile Asn Ser Thr Ser Thr Gln Thr Ser Asn Glu Ser Ala Pro Gln
    850                 855                 860                 
Ser Ser Pro Val Gly Arg Trp Arg Phe Cys Ile Asn Gln Thr Ile Arg
865                 870                 875                 880 
Asn Arg Glu Thr Gln Ser Pro Pro Ser Leu Gln His Ser Met Ser Ala
                885                 890                 895     
Val Pro Gly Arg His Pro Leu Pro Ser Pro Lys Asn Thr Ser Asn Lys
            900                 905                 910         
Glu Ile Ser Arg Asp Thr Leu Leu Thr Ile Glu Asn Asn Pro Cys His
        915                 920                 925             
Arg Ala Leu Phe Thr Ser Lys Ser Glu His Lys Asp Val Val Asp Gly
    930                 935                 940                 
Lys Ile Ser Glu Cys Ala Ser Val Glu Thr Lys Gln Pro Ala Ile Leu
945                 950                 955                 960 
Tyr Gln Val Glu Asp Asn Arg Gln Ile Met Ala Pro Val Thr Asn Ser
                965                 970                 975     
Ser Ser Tyr Ser Thr Thr Ser Val Arg Ala Val Pro Ala Glu Cys Glu
            980                 985                 990         
Gly Leu Thr Lys Gln Ala Ser Ile Phe Ile Pro Val Tyr Pro Cys His
        995                 1000                1005            
Gln Thr Ala Ser Gln Ala Asp Ala Leu Met Ser His Pro Gly Glu Ser
    1010                1015                1020                
Thr Gln Thr Ser Gly Asn Ser Leu Thr Thr Leu Ala Phe Asp Gln Lys
1025                1030                1035                1040
Pro Gln Thr Leu Ser Val Gln Gln Pro Ala Met Asp Ala Glu Phe Ile
                1045                1050                1055    
Ser Gln Glu Gly Glu Thr Thr Val Asn Thr Glu Ala Ser Ser Pro Lys
            1060                1065                1070        
Thr Val Ile Pro Thr Gln Thr Pro Gly Leu Glu Pro Thr Thr Leu Gln
        1075                1080                1085            
Pro Thr Thr Val Leu Glu Ser Asp Gly Glu Arg Pro Pro Lys Leu Glu
    1090                1095                1100                
Phe Ala Asp Asn Arg Ile Lys Thr Leu Asp Glu Lys Leu Arg Asn Leu
1105                1110                1115                1120
Leu Tyr Gln Glu His Ser Ile Ser Ser Ile Tyr Pro Glu Ser Gln Lys
                1125                1130                1135    
Asp Thr Gln Ser Ile Asp Ser Pro Phe Ser Ser Ser Ala Glu Asp Thr
            1140                1145                1150        
Leu Ser Cys Pro Val Thr Glu Val Ile Ala Ile Ser His Cys Gly Ile
        1155                1160                1165            
Lys Asp Ser Pro Val Gln Ser Pro Asn Phe Gln Gln Thr Gly Ser Lys
    1170                1175                1180                
Leu Leu Ser Asn Val Ala Ala Ser Gln Pro Ala Asn Ile Ser Val Phe
1185                1190                1195                1200
Lys Arg Asp Leu Asn Val Ile Thr Ser Val Pro Ser Glu Leu Cys Leu
                1205                1210                1215    
His Glu Met Ser Ser Asp Ala Ser Leu Pro Gly Asp Pro Glu Ala Tyr
            1220                1225                1230        
Pro Ala Ala Val Ser Ser Gly Gly Ala Ile His Leu Gln Thr Gly Gly
        1235                1240                1245            
Gly Tyr Phe Gly Leu Ser Phe Thr Cys Pro Ser Leu Lys Asn Pro Ile
    1250                1255                1260                
Ser Lys Lys Ser Trp Thr Arg Lys Leu Lys Ser Trp Ala Tyr Arg Leu
1265                1270                1275                1280
Arg Gln Ser Thr Ser Phe Phe Lys Arg Ser Lys Val Arg Gln Val Glu
                1285                1290                1295    
Thr Glu Glu Met Arg Ser Ala Ile Ala Pro Asp Pro Ile Pro Leu Thr
            1300                1305                1310        
Arg Glu Ser Thr Ala Asp Thr Arg Ala Leu Asn Arg Cys Lys Ala Met
        1315                1320                1325            
Ser Gly Ser Phe Gln Arg Gly Arg Phe Gln Val Ile Thr Ile Pro Gln
    1330                1335                1340                
Gln Gln Ser Ala Lys Met Thr Ser Phe Gly Ile Glu His Ile Ser Val
1345                1350                1355                1360
Phe Ser Glu Thr Asn His Ser Ser Glu Glu Ala Phe Ile Lys Thr Ala
                1365                1370                1375    
Lys Ser Gln Leu Val Glu Ile Glu Pro Ala Thr Gln Asn Pro Lys Thr
            1380                1385                1390        
Ser Phe Ser Tyr Glu Lys Leu Gln Ala Leu Gln Glu Thr Cys Lys Glu
        1395                1400                1405            
Asn Lys Gly Val Pro Lys Gln Gly Asp Asn Phe Leu Ser Phe Ser Ala
    1410                1415                1420                
Ala Cys Glu Thr Asp Val Ser Ser Val Thr Pro Glu Lys Glu Phe Glu
1425                1430                1435                1440
Glu Thr Ser Ala Thr Gly Ser Ser Met Gln Ser Gly Ser Glu Leu Leu
                1445                1450                1455    
Leu Lys Glu Arg Glu Ile Leu Thr Ala Gly Lys Gln Pro Ser Ser Asp
            1460                1465                1470        
Ser Glu Phe Ser Ala Ser Leu Ala Gly Ser Gly Lys Ser Val Ala Lys
        1475                1480                1485            
Thr Gly Pro Glu Ser Asn Gln Cys Leu Pro His His Glu Glu Gln Ala
    1490                1495                1500                
Tyr Ala Gln Thr Gln Ser Ser Leu Phe Tyr Ser Pro Ser Ser Pro Met
1505                1510                1515                1520
Ser Ser Asp Asp Glu Ser Glu Ile Glu Asp Glu Asp Leu Lys Val Glu
                1525                1530                1535    
Leu Gln Arg Leu Arg Glu Lys His Ile Gln Glu Val Val Asn Leu Gln
            1540                1545                1550        
Thr Gln Gln Asn Lys Glu Leu Gln Glu Leu Tyr Glu Arg Leu Arg Ser
        1555                1560                1565            
Ile Lys Asp Ser Lys Thr Gln Ser Thr Glu Ile Pro Leu Pro Pro Ala
    1570                1575                1580                
Ser Pro Arg Arg Pro Arg Ser Phe Lys Ser Lys Leu Arg Ser Arg Pro
1585                1590                1595                1600
Gln Ser Leu Thr His Val Asp Asn Gly Ile Val Ala Thr Gly Lys Ser
                1605                1610                1615    
Cys Leu Ile Asn Glu Leu Glu Asn Pro Leu Cys Val Glu Ser Asn Ala
            1620                1625                1630        
Ala Ser Cys Gln Gln Ser Pro Ala Ser Lys Lys Gly Met Phe Thr Asp
        1635                1640                1645            
Asp Leu His Lys Leu Val Asp Asp Trp Thr Lys Glu Ala Val Gly Asn
    1650                1655                1660                
Ser Leu Ile Lys Pro Ser Leu Asn Gln Leu Lys Gln Ser Gln His Lys
1665                1670                1675                1680
Leu Glu Thr Glu Asn Trp Asn Lys Val Ser Glu Asn Thr Pro Ser Thr
                1685                1690                1695    
Met Gly Tyr Thr Ser Thr Trp Ile Ser Ser Leu Ser Gln Ile Arg Gly
            1700                1705                1710        
Ala Val Pro Thr Ser Leu Pro Gln Gly Leu Ser Leu Pro Ser Phe Pro
        1715                1720                1725            
Gly Pro Leu Ser Ser Tyr Gly Met Pro His Val Cys Gln Tyr Asn Ala
    1730                1735                1740                
Val Ala Gly Ala Gly Tyr Pro Val Gln Trp Val Gly Ile Ser Gly Thr
1745                1750                1755                1760
Thr Gln Gln Ser Val Val Ile Pro Ala Gln Ser Gly Gly Pro Phe Gln
                1765                1770                1775    
Pro Gly Met Asn Met Gln Ala Phe Pro Thr Ser Ser Val Gln Asn Pro
            1780                1785                1790        
Ala Thr Ile Pro Pro Gly Pro Lys
        1795                1800


<210> 8133
<211> 454
<212> PRT
<213> Homo sapiens

<400> 8133
Met Glu Leu Ala Thr Arg Tyr Gln Ile Pro Lys Glu Val Ala Asp Ile
 1               5                  10                  15      
Phe Asn Ala Pro Ser Asp Asp Glu Glu Phe Val Gly Phe Arg Asp Asp
            20                  25                  30          
Val Pro Met Glu Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp
        35                  40                  45              
Ser Leu Glu Ser Gly Lys Gln Gln Asp Val Arg Phe His Ser Lys Tyr
    50                  55                  60                  
Phe Thr Glu Glu Leu Arg Arg Ile Phe Ile Glu Asp Thr Asp Ser Glu
65                  70                  75                  80  
Thr Glu Asp Phe Ala Gly Phe Thr Gln Ser Asp Leu Asn Gly Lys Thr
                85                  90                  95      
Asn Pro Glu Val Met Val Val Glu Ser Asp Leu Ser Asp Asp Gly Lys
            100                 105                 110         
Ala Ser Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp Lys Ala
        115                 120                 125             
Thr Pro Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu Arg Val
    130                 135                 140                 
Ala Phe Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp Lys Asn
145                 150                 155                 160 
Ser Ser Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn Glu Lys
                165                 170                 175     
Lys Thr Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile Gln Arg
            180                 185                 190         
Glu Asp Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu Ser Gln
        195                 200                 205             
Glu Ser Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys Glu Asn
    210                 215                 220                 
Lys Ala Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met Pro Asp
225                 230                 235                 240 
Phe Phe Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys Thr Val
                245                 250                 255     
Arg Arg Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn Pro Thr
            260                 265                 270         
Arg Ser Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe Thr Val
        275                 280                 285             
Ser Ala Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg Arg Lys
    290                 295                 300                 
Thr Ile Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg Ile Ser
305                 310                 315                 320 
Ser Phe Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu Asn Val
                325                 330                 335     
Ala Ile Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly Asn Thr
            340                 345                 350         
Cys His Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val Cys Arg
        355                 360                 365             
Asn Gln Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu
    370                 375                 380                 
Arg Asn Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp Pro Asp
385                 390                 395                 400 
Trp Val Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr Cys Arg
                405                 410                 415     
Lys Arg Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu Ala Lys
            420                 425                 430         
Phe Tyr Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu Gln Lys
        435                 440                 445             
Glu Leu Val Glu Asp Asn
    450                 


<210> 8134
<211> 461
<212> PRT
<213> Homo sapiens

<400> 8134
Gly Thr Arg Arg Leu Gly Arg Met Glu Leu Ala Thr Arg Tyr Gln Ile
 1               5                  10                  15      
Pro Lys Glu Val Ala Asp Ile Phe Asn Ala Pro Ser Asp Asp Glu Glu
            20                  25                  30          
Phe Val Gly Phe Arg Asp Asp Val Pro Met Glu Thr Leu Ser Ser Glu
        35                  40                  45              
Glu Ser Cys Asp Ser Phe Asp Ser Leu Glu Ser Gly Lys Gln Gln Asp
    50                  55                  60                  
Val Arg Phe His Ser Lys Tyr Phe Thr Glu Glu Leu Arg Arg Ile Phe
65                  70                  75                  80  
Ile Glu Asp Thr Asp Ser Glu Thr Glu Asp Phe Ala Gly Phe Thr Gln
                85                  90                  95      
Ser Asp Leu Asn Gly Lys Thr Asn Pro Glu Val Met Val Val Glu Ser
            100                 105                 110         
Asp Leu Ser Asp Asp Gly Lys Ala Ser Leu Val Ser Glu Glu Glu Glu
        115                 120                 125             
Asp Glu Glu Glu Asp Lys Ala Thr Pro Arg Arg Ser Arg Ser Arg Arg
    130                 135                 140                 
Ser Ser Ile Gly Leu Arg Val Ala Phe Gln Phe Pro Thr Lys Lys Leu
145                 150                 155                 160 
Ala Asn Lys Pro Asp Lys Asn Ser Ser Ser Glu Gln Leu Phe Ser Ser
                165                 170                 175     
Ala Arg Leu Gln Asn Glu Lys Lys Thr Ile Leu Glu Arg Lys Lys Asp
            180                 185                 190         
Cys Arg Gln Val Ile Gln Arg Glu Asp Ser Thr Ser Glu Ser Glu Asp
        195                 200                 205             
Asp Ser Arg Asp Glu Ser Gln Glu Ser Ser Asp Ala Leu Leu Lys Arg
    210                 215                 220                 
Thr Met Asn Ile Lys Glu Asn Lys Ala Met Leu Ala Gln Leu Leu Ala
225                 230                 235                 240 
Glu Leu Asn Ser Met Pro Asp Phe Phe Pro Val Arg Thr Pro Thr Ser
                245                 250                 255     
Ala Ser Arg Lys Lys Thr Val Arg Arg Ala Phe Ser Glu Gly Gln Ile
            260                 265                 270         
Thr Arg Arg Met Asn Pro Thr Arg Ser Ala Arg Pro Pro Glu Lys Phe
        275                 280                 285             
Ala Leu Glu Asn Phe Thr Val Ser Ala Ala Lys Phe Ala Glu Glu Phe
    290                 295                 300                 
Tyr Ser Phe Arg Arg Arg Lys Thr Ile Gly Gly Lys Cys Arg Glu Tyr
305                 310                 315                 320 
Arg Arg Arg His Arg Ile Ser Ser Phe Arg Pro Val Glu Asp Ile Thr
                325                 330                 335     
Glu Glu Asp Leu Glu Asn Val Ala Ile Thr Val Arg Asp Lys Ile Tyr
            340                 345                 350         
Asp Lys Val Leu Gly Asn Thr Cys His Gln Cys Arg Gln Lys Thr Ile
        355                 360                 365             
Asp Thr Lys Thr Val Cys Arg Asn Gln Gly Cys Cys Gly Val Arg Gly
    370                 375                 380                 
Gln Phe Cys Gly Pro Cys Leu Arg Asn Arg Tyr Gly Glu Asp Val Arg
385                 390                 395                 400 
Ser Ala Leu Leu Asp Pro Asp Trp Val Cys Pro Pro Cys Arg Gly Ile
                405                 410                 415     
Cys Asn Cys Ser Tyr Cys Arg Lys Arg Asp Gly Arg Cys Ala Thr Gly
            420                 425                 430         
Ile Leu Ile His Leu Ala Lys Phe Tyr Gly Tyr Asp Asn Val Lys Glu
        435                 440                 445             
Tyr Leu Glu Ser Leu Gln Lys Glu Leu Val Glu Asp Asn
    450                 455                 460     


<210> 8135
<211> 1275
<212> PRT
<213> Homo sapiens

<400> 8135
Met Gln Lys Ala Ile Arg Leu Asn Asp Gly His Val Ala Pro Leu Gly
 1               5                  10                  15      
Leu Leu Ala Arg Lys Asp Gly Thr Arg Lys Gly Tyr Leu Ser Lys Arg
            20                  25                  30          
Ser Ser Asp Asn Thr Lys Trp Gln Thr Lys Trp Phe Ala Leu Leu Gln
        35                  40                  45              
Asn Leu Leu Phe Tyr Phe Glu Ser Asp Ser Ser Ser Arg Pro Ser Gly
    50                  55                  60                  
Leu Tyr Leu Leu Glu Gly Cys Val Cys Asp Arg Ala Pro Ser Pro Lys
65                  70                  75                  80  
Pro Ala Leu Ser Ala Lys Glu Pro Leu Glu Lys Gln His Tyr Phe Thr
                85                  90                  95      
Val Asn Phe Ser His Glu Asn Gln Lys Ala Leu Glu Leu Arg Thr Glu
            100                 105                 110         
Asp Ala Lys Asp Cys Asp Glu Trp Val Ala Ala Ile Ala His Ala Ser
        115                 120                 125             
Tyr Arg Thr Leu Ala Thr Glu His Glu Ala Leu Met Gln Lys Tyr Leu
    130                 135                 140                 
His Leu Leu Gln Ile Val Glu Thr Glu Lys Thr Val Ala Lys Gln Leu
145                 150                 155                 160 
Arg Gln Gln Ile Glu Asp Gly Glu Ile Glu Ile Glu Arg Leu Lys Ala
                165                 170                 175     
Glu Ile Thr Ser Leu Leu Lys Asp Asn Glu Arg Ile Gln Ser Thr Gln
            180                 185                 190         
Thr Val Ala Pro Asn Asp Glu Asp Ser Asp Ile Lys Lys Ile Lys Lys
        195                 200                 205             
Val Gln Ser Phe Leu Arg Gly Trp Leu Cys Arg Arg Lys Trp Lys Thr
    210                 215                 220                 
Ile Ile Gln Asp Tyr Ile Arg Ser Pro His Ala Asp Ser Met Arg Lys
225                 230                 235                 240 
Arg Asn Gln Val Val Phe Ser Met Leu Glu Ala Glu Ala Glu Tyr Val
                245                 250                 255     
Gln Gln Leu His Ile Leu Val Asn Asn Phe Leu Arg Pro Leu Arg Met
            260                 265                 270         
Ala Ala Ser Ser Lys Lys Pro Pro Ile Thr His Asp Asp Val Ser Ser
        275                 280                 285             
Ile Phe Leu Asn Ser Glu Thr Ile Met Phe Leu His Gln Ile Phe Tyr
    290                 295                 300                 
Gln Gly Leu Lys Ala Arg Ile Ser Ser Trp Pro Thr Leu Val Leu Ala
305                 310                 315                 320 
Asp Leu Leu Asp Ile Leu Leu Pro Met Leu Asn Ile Tyr Gln Glu Phe
                325                 330                 335     
Val Arg Asn His Gln Tyr Ser Leu Gln Ile Leu Ala His Cys Lys Gln
            340                 345                 350         
Asn Arg Asp Phe Asp Lys Leu Leu Lys His Tyr Glu Ala Lys Pro Asp
        355                 360                 365             
Cys Glu Glu Arg Thr Leu Glu Thr Phe Leu Thr Tyr Pro Met Phe Gln
    370                 375                 380                 
Ile Pro Arg Tyr Ile Leu Thr Leu His Asp Val Leu Ala His Thr Pro
385                 390                 395                 400 
His Glu His Val Glu Arg Asn Ser Leu Asp Tyr Ala Lys Ser Lys Leu
                405                 410                 415     
Glu Glu Leu Ser Arg Ile Met His Asp Glu Val Ser Glu Thr Glu Asn
            420                 425                 430         
Ile Arg Lys Asn Leu Ala Ile Glu Arg Met Ile Ile Glu Gly Cys Glu
        435                 440                 445             
Ile Leu Leu Asp Thr Ser Gln Thr Phe Val Arg Gln Gly Ser Leu Ile
    450                 455                 460                 
Gln Val Pro Met Ser Glu Lys Gly Lys Ile Thr Arg Gly Arg Leu Gly
465                 470                 475                 480 
Ser Leu Ser Leu Glu Lys Glu Gly Glu Arg Gln Cys Phe Leu Phe Ser
                485                 490                 495     
Lys His Leu Ile Ile Cys Thr Arg Gly Ser Gly Gly Lys Leu His Leu
            500                 505                 510         
Thr Lys Asn Gly Val Ile Ser Leu Ile Asp Cys Thr Leu Leu Glu Glu
        515                 520                 525             
Pro Glu Ser Thr Glu Glu Glu Ala Lys Gly Ser Gly Gln Asp Ile Asp
    530                 535                 540                 
His Leu Asp Phe Lys Ile Gly Val Glu Pro Lys Asp Ser Pro Pro Phe
545                 550                 555                 560 
Thr Val Ile Leu Val Ala Ser Ser Arg Gln Glu Lys Ala Ala Trp Thr
                565                 570                 575     
Ser Asp Ile Ser Gln Cys Val Asp Asn Ile Arg Cys Asn Gly Leu Met
            580                 585                 590         
Met Asn Ala Phe Glu Glu Asn Ser Lys Val Thr Val Pro Gln Met Ile
        595                 600                 605             
Lys Arg Thr Arg Glu Gly Thr Arg Glu Ala Glu Met Ser Arg Ser Asp
    610                 615                 620                 
Ala Ser Leu Tyr Cys Asp Asp Val Asp Ile Arg Phe Ser Lys Thr Met
625                 630                 635                 640 
Asn Ser Cys Lys Val Leu Gln Ile Arg Tyr Ala Ser Val Glu Arg Leu
                645                 650                 655     
Leu Glu Arg Leu Thr Asp Leu Arg Phe Leu Ser Ile Asp Phe Leu Asn
            660                 665                 670         
Thr Phe Leu His Ser Tyr Arg Val Phe Thr Thr Ala Ile Val Val Leu
        675                 680                 685             
Asp Lys Leu Ile Thr Ile Tyr Lys Lys Pro Ile Ser Ala Ile Pro Ala
    690                 695                 700                 
Arg Trp Leu Arg Ser Leu Glu Leu Leu Phe Ala Ser Gly Gln Asn Asn
705                 710                 715                 720 
Lys Leu Leu Tyr Gly Glu Pro Pro Lys Ser Pro Arg Ala Thr Arg Lys
                725                 730                 735     
Phe Ser Ser Pro Pro Pro Leu Ser Ile Thr Lys Thr Ser Ser Pro Ser
            740                 745                 750         
Arg Arg Arg Lys Leu Ile Ser Leu Asn Ile Pro Ile Ile Thr Gly Gly
        755                 760                 765             
Lys Ala Leu Asp Leu Ala Gly Ser Leu Ser Cys Asn Ser Asn Gly Tyr
    770                 775                 780                 
Thr Ser Met Tyr Ser Ala Met Ser Pro Phe Ser Lys Ala Thr Leu Asp
785                 790                 795                 800 
Thr Ser Lys Leu Tyr Val Ser Ser Ser Phe Thr Asn Lys Ile Pro Asp
                805                 810                 815     
Glu Gly Asp Thr Thr Pro Glu Lys Pro Glu Asp Pro Ser Ala Leu Ser
            820                 825                 830         
Lys Gln Ser Ser Glu Val Ser Met Arg Glu Glu Ser Asp Ile Asp Gln
        835                 840                 845             
Asn Gln Ser Asp Asp Gly Asp Thr Glu Thr Ser Pro Thr Lys Ser Pro
    850                 855                 860                 
Thr Thr Pro Lys Ser Val Lys Asn Lys Asn Ser Ser Glu Phe Pro Leu
865                 870                 875                 880 
Phe Ser Tyr Asn Asn Gly Val Val Met Thr Ser Cys Arg Glu Leu Asp
                885                 890                 895     
Asn Asn Arg Ser Ala Leu Ser Ala Ala Ser Ala Phe Ala Ile Ala Thr
            900                 905                 910         
Ala Gly Ala Asn Glu Gly Thr Pro Asn Lys Glu Lys Tyr Arg Arg Met
        915                 920                 925             
Ser Leu Ala Ser Ala Gly Phe Pro Pro Asp Gln Arg Asn Gly Asp Lys
    930                 935                 940                 
Glu Phe Val Ile Arg Arg Ala Ala Thr Asn Arg Val Leu Asn Val Leu
945                 950                 955                 960 
Arg His Trp Val Ser Lys His Ser Gln Asp Phe Glu Thr Asn Asp Glu
                965                 970                 975     
Leu Lys Cys Lys Val Ile Gly Phe Leu Glu Glu Val Met His Asp Pro
            980                 985                 990         
Glu Leu Leu Thr Gln Glu Arg Lys Ala Ala Ala Asn Ile Ile Arg Thr
        995                 1000                1005            
Leu Thr Gln Glu Asp Pro Gly Asp Asn Gln Ile Thr Leu Glu Glu Ile
    1010                1015                1020                
Thr Gln Met Ala Glu Gly Val Lys Ala Glu Pro Phe Glu Asn His Ser
1025                1030                1035                1040
Ala Leu Glu Ile Ala Glu Gln Leu Thr Leu Leu Asp His Leu Val Phe
                1045                1050                1055    
Lys Lys Ile Pro Tyr Glu Glu Phe Phe Gly Gln Gly Trp Met Lys Leu
            1060                1065                1070        
Glu Lys Asn Glu Arg Thr Pro Tyr Ile Met Lys Thr Thr Lys His Phe
        1075                1080                1085            
Asn Asp Ile Ser Asn Leu Ile Ala Ser Glu Ile Ile Arg Asn Glu Asp
    1090                1095                1100                
Ile Asn Ala Arg Val Ser Ala Ile Glu Lys Trp Val Ala Val Ala Asp
1105                1110                1115                1120
Ile Cys Arg Cys Leu His Asn Tyr Asn Ala Val Leu Glu Ile Thr Ser
                1125                1130                1135    
Ser Met Asn Arg Ser Ala Ile Phe Arg Leu Lys Lys Thr Trp Leu Lys
            1140                1145                1150        
Val Ser Lys Gln Thr Lys Ala Leu Ile Asp Lys Leu Gln Lys Leu Val
        1155                1160                1165            
Ser Ser Glu Gly Arg Phe Lys Asn Leu Arg Glu Ala Leu Lys Asn Cys
    1170                1175                1180                
Asp Pro Pro Cys Val Pro Tyr Leu Gly Met Tyr Leu Thr Asp Leu Ala
1185                1190                1195                1200
Phe Ile Glu Glu Gly Thr Pro Asn Tyr Thr Glu Asp Gly Leu Val Asn
                1205                1210                1215    
Phe Ser Lys Met Arg Met Ile Ser His Ile Ile Arg Glu Ile Arg Gln
            1220                1225                1230        
Phe Gln Gln Thr Ala Tyr Lys Ile Glu His Gln Ala Lys Val Thr Gln
        1235                1240                1245            
Tyr Leu Leu Asp Gln Ser Phe Val Met Asp Glu Glu Ser Leu Tyr Glu
    1250                1255                1260                
Ser Ser Leu Arg Ile Glu Pro Lys Leu Pro Thr
1265                1270                1275


<210> 8136
<211> 489
<212> PRT
<213> Homo sapiens

<400> 8136
Met Tyr Ser Ala Met Ser Pro Phe Ser Lys Ala Thr Leu Asp Thr Ser
 1               5                  10                  15      
Lys Leu Tyr Val Ser Ser Ser Phe Thr Asn Lys Ile Pro Asp Glu Gly
            20                  25                  30          
Asp Thr Thr Pro Glu Lys Pro Glu Asp Pro Ser Ala Leu Ser Lys Gln
        35                  40                  45              
Ser Ser Glu Val Ser Met Arg Glu Glu Ser Asp Ile Asp Gln Asn Gln
    50                  55                  60                  
Ser Asp Asp Gly Asp Thr Glu Thr Ser Pro Thr Lys Ser Pro Thr Thr
65                  70                  75                  80  
Pro Lys Ser Val Lys Asn Lys Asn Ser Ser Glu Phe Pro Leu Phe Ser
                85                  90                  95      
Tyr Asn Asn Gly Val Val Met Thr Ser Cys Arg Glu Leu Asp Asn Asn
            100                 105                 110         
Arg Ser Ala Leu Ser Ala Ala Ser Ala Phe Ala Ile Ala Thr Ala Gly
        115                 120                 125             
Ala Asn Glu Gly Thr Pro Asn Lys Glu Lys Tyr Arg Arg Met Ser Leu
    130                 135                 140                 
Ala Ser Ala Gly Phe Pro Pro Asp Gln Arg Asn Gly Asp Lys Glu Phe
145                 150                 155                 160 
Val Ile Arg Arg Ala Ala Thr Asn Arg Val Leu Asn Val Leu Arg His
                165                 170                 175     
Trp Val Ser Lys His Ser Gln Asp Phe Glu Thr Asn Asp Glu Leu Lys
            180                 185                 190         
Cys Lys Val Ile Gly Phe Leu Glu Glu Val Met His Asp Pro Glu Leu
        195                 200                 205             
Leu Thr Gln Glu Arg Lys Ala Ala Ala Asn Ile Ile Arg Thr Leu Thr
    210                 215                 220                 
Gln Glu Asp Pro Gly Asp Asn Gln Ile Thr Leu Glu Glu Ile Thr Gln
225                 230                 235                 240 
Met Ala Glu Gly Val Lys Ala Glu Pro Phe Glu Asn His Ser Ala Leu
                245                 250                 255     
Glu Ile Ala Glu Gln Leu Thr Leu Leu Asp His Leu Val Phe Lys Lys
            260                 265                 270         
Ile Pro Tyr Glu Glu Phe Phe Gly Gln Gly Trp Met Lys Leu Glu Lys
        275                 280                 285             
Asn Glu Arg Thr Pro Tyr Ile Met Lys Thr Thr Lys His Phe Asn Asp
    290                 295                 300                 
Ile Ser Asn Leu Ile Ala Ser Glu Ile Ile Arg Asn Glu Asp Ile Asn
305                 310                 315                 320 
Ala Arg Val Ser Ala Ile Glu Lys Trp Val Ala Val Ala Asp Ile Cys
                325                 330                 335     
Arg Cys Leu His Asn Tyr Asn Ala Val Leu Glu Ile Thr Ser Ser Met
            340                 345                 350         
Asn Arg Ser Ala Ile Phe Arg Leu Lys Lys Thr Trp Leu Lys Val Ser
        355                 360                 365             
Lys Gln Thr Lys Ala Leu Ile Asp Lys Leu Gln Lys Leu Val Ser Ser
    370                 375                 380                 
Glu Gly Arg Phe Lys Asn Leu Arg Glu Ala Leu Lys Asn Cys Asp Pro
385                 390                 395                 400 
Pro Cys Val Pro Tyr Leu Gly Met Tyr Leu Thr Asp Leu Ala Phe Ile
                405                 410                 415     
Glu Glu Gly Thr Pro Asn Tyr Thr Glu Asp Gly Leu Val Asn Phe Ser
            420                 425                 430         
Lys Met Arg Met Ile Ser His Ile Ile Arg Glu Ile Arg Gln Phe Gln
        435                 440                 445             
Gln Thr Ala Tyr Lys Ile Glu His Gln Ala Lys Val Thr Gln Tyr Leu
    450                 455                 460                 
Leu Asp Gln Ser Phe Val Met Asp Glu Glu Ser Leu Tyr Glu Ser Ser
465                 470                 475                 480 
Leu Arg Ile Glu Pro Lys Leu Pro Thr
                485                 


<210> 8137
<211> 97
<212> PRT
<213> Homo sapiens

<400> 8137
Met Gly Lys Lys Gln Ser Arg Lys Ala Glu Asn Tyr Lys Asn Gln Ser
 1               5                  10                  15      
Ala Ser Pro Pro Pro Lys Asp Arg Ser Ser Ser Pro Ala Thr Glu Gln
            20                  25                  30          
Ser Trp Thr Gln Asn Asp Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg
        35                  40                  45              
Glu Ser Asp Phe Ser Glu Leu Lys Glu Glu Val Arg Thr His Arg Lys
    50                  55                  60                  
Glu Ala Lys Asn Leu Glu Lys Arg Leu Asp Lys Trp Leu Thr Arg Val
65                  70                  75                  80  
Thr Ser Val Glu Lys Ser Leu Asn Asp Leu Met Glu Leu Lys Thr Met
                85                  90                  95      
Ala
    


<210> 8138
<211> 224
<212> PRT
<213> Homo sapiens

<400> 8138
Met Gly Arg Ile Asp Arg Arg Arg Cys Gly Cys Thr Lys Gly Met Leu
 1               5                  10                  15      
Arg Asn His Gly Pro Pro Val His Thr Ala Ala Trp Val Asp Leu Asn
            20                  25                  30          
Ile Ser Val Leu Ser Glu Lys Gly Trp Phe Arg Phe Trp Tyr Leu Val
        35                  40                  45              
Pro Glu Leu Ser Asn His His Val Glu Gln Lys Gly Lys Thr Thr Lys
    50                  55                  60                  
Lys Arg Pro Gln Cys Ala Thr Ser Lys Val Phe Ala Thr Phe Asp Gln
65                  70                  75                  80  
Ser Gln Ile Gln Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn
                85                  90                  95      
Arg Asp Gly Phe Ile Ser Lys Glu Asp Leu His Gly Met Leu Ala Ser
            100                 105                 110         
Leu Gly Lys Asn Pro Thr Asp Ala Cys Leu Asp Ala Val Met Asn Glu
        115                 120                 125             
Ala Pro Gly Pro Ile Asn Phe Thr Met Leu Leu Ala Met Phe Gly Lys
    130                 135                 140                 
Lys Leu Asn Gly Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala
145                 150                 155                 160 
Cys Phe Asp Glu Glu Ala Thr Gly Thr Ile Gln Glu Asp Tyr Leu Arg
                165                 170                 175     
Glu Leu Leu Thr Thr Val Gly Asp Gln Phe Thr Asp Glu Glu Val Asp
            180                 185                 190         
Glu Leu Tyr Thr Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr
        195                 200                 205             
Ile Glu Phe Thr Ser Ile Leu Lys His Gly Val Lys Asp Lys Asp Asp
    210                 215                 220                 


<210> 8139
<211> 764
<212> PRT
<213> Homo sapiens

<400> 8139
Met Ser Asp Thr Arg Arg Arg Val Lys Val Tyr Thr Leu Asn Glu Asp
 1               5                  10                  15      
Arg Gln Trp Asp Asp Arg Gly Thr Gly His Val Ser Ser Thr Tyr Val
            20                  25                  30          
Glu Glu Leu Lys Gly Met Ser Leu Leu Val Arg Ala Glu Ser Asp Gly
        35                  40                  45              
Ser Leu Leu Leu Glu Ser Lys Ile Asn Pro Asn Thr Ala Tyr Gln Lys
    50                  55                  60                  
Gln Gln Asp Thr Leu Ile Val Trp Ser Glu Ala Glu Asn Tyr Asp Leu
65                  70                  75                  80  
Ala Leu Ser Phe Gln Glu Lys Ala Gly Cys Asp Glu Ile Trp Glu Lys
                85                  90                  95      
Ile Cys Gln Val Gln Gly Lys Asp Pro Ser Val Glu Val Thr Gln Asp
            100                 105                 110         
Leu Ile Asp Glu Ser Glu Glu Glu Arg Phe Glu Glu Met Pro Glu Thr
        115                 120                 125             
Ser His Leu Ile Asp Leu Pro Thr Cys Glu Leu Asn Lys Leu Glu Glu
    130                 135                 140                 
Ile Ala Asp Leu Val Thr Ser Val Leu Ser Ser Pro Ile Arg Arg Glu
145                 150                 155                 160 
Lys Leu Ala Leu Ala Leu Glu Asn Glu Gly Tyr Ile Lys Lys Leu Leu
                165                 170                 175     
Gln Leu Phe Gln Ala Cys Glu Asn Leu Glu Asn Thr Glu Gly Leu His
            180                 185                 190         
His Leu Tyr Glu Ile Ile Arg Gly Ile Leu Phe Leu Asn Lys Ala Thr
        195                 200                 205             
Leu Phe Glu Val Met Phe Ser Asp Glu Cys Ile Met Asp Val Val Gly
    210                 215                 220                 
Cys Leu Glu Tyr Asp Pro Ala Leu Ala Gln Pro Lys Arg His Arg Glu
225                 230                 235                 240 
Phe Leu Thr Lys Thr Ala Lys Phe Lys Glu Val Ile Pro Ile Thr Asp
                245                 250                 255     
Ser Glu Leu Arg Gln Lys Ile His Gln Thr Tyr Arg Val Gln Tyr Ile
            260                 265                 270         
Gln Asp Ile Ile Leu Pro Thr Pro Ser Val Phe Glu Glu Asn Phe Leu
        275                 280                 285             
Ser Thr Leu Thr Ser Phe Ile Phe Phe Asn Lys Val Glu Ile Val Ser
    290                 295                 300                 
Met Leu Gln Glu Asp Glu Lys Phe Leu Ser Glu Val Phe Ala Gln Leu
305                 310                 315                 320 
Thr Asp Glu Ala Thr Asp Asp Asp Lys Arg Arg Glu Leu Val Asn Phe
                325                 330                 335     
Phe Lys Glu Phe Cys Ala Phe Ser Gln Thr Leu Gln Pro Gln Asn Arg
            340                 345                 350         
Asp Ala Phe Phe Lys Thr Leu Ala Lys Leu Gly Ile Leu Pro Ala Leu
        355                 360                 365             
Glu Ile Val Met Gly Met Asp Asp Leu Gln Val Arg Ser Ala Ala Thr
    370                 375                 380                 
Asp Ile Phe Ser Tyr Leu Val Glu Phe Ser Pro Ser Met Val Arg Glu
385                 390                 395                 400 
Phe Val Met Gln Glu Ala Gln Gln Ser Asp Asp Asp Ile Leu Leu Ile
                405                 410                 415     
Asn Val Val Ile Glu Gln Met Ile Cys Asp Thr Asp Pro Glu Leu Gly
            420                 425                 430         
Gly Ala Val Gln Leu Met Gly Leu Leu Arg Thr Leu Ile Asp Pro Glu
        435                 440                 445             
Asn Met Leu Ala Thr Thr Asn Lys Thr Glu Lys Ser Glu Phe Leu Asn
    450                 455                 460                 
Phe Phe Tyr Asn His Cys Met His Val Leu Thr Ala Pro Leu Leu Thr
465                 470                 475                 480 
Asn Thr Ser Glu Asp Lys Cys Glu Lys Asp Asn Ile Val Gly Ser Asn
                485                 490                 495     
Lys Asn Asn Thr Ile Cys Pro Gly Ala Leu Arg Phe Met Arg Arg Ile
            500                 505                 510         
Ile Gly Leu Lys Asp Glu Phe Tyr Asn Arg Tyr Ile Thr Lys Gly Asn
        515                 520                 525             
Leu Phe Glu Pro Val Ile Asn Ala Leu Leu Asp Asn Gly Thr Arg Tyr
    530                 535                 540                 
Asn Leu Leu Asn Ser Ala Val Ile Glu Leu Phe Glu Phe Ile Arg Val
545                 550                 555                 560 
Glu Asp Ile Lys Ser Leu Thr Ala His Ile Val Glu Asn Phe Tyr Lys
                565                 570                 575     
Ala Leu Glu Ser Ile Glu Tyr Val Gln Thr Phe Lys Gly Leu Lys Thr
            580                 585                 590         
Lys Tyr Glu Gln Glu Lys Asp Arg Gln Asn Gln Lys Leu Asn Ser Val
        595                 600                 605             
Pro Ser Ile Leu Arg Ser Asn Arg Phe Arg Arg Asp Ala Lys Ala Leu
    610                 615                 620                 
Glu Glu Asp Glu Glu Met Trp Phe Asn Glu Asp Glu Glu Glu Glu Gly
625                 630                 635                 640 
Lys Ala Val Val Ala Pro Val Glu Lys Pro Lys Pro Glu Asp Asp Phe
                645                 650                 655     
Pro Asp Asn Tyr Glu Lys Phe Met Glu Thr Lys Lys Ala Lys Glu Ser
            660                 665                 670         
Glu Asp Lys Glu Asn Leu Pro Lys Arg Thr Ser Pro Gly Gly Phe Lys
        675                 680                 685             
Phe Thr Phe Ser His Ser Ala Ser Ala Ala Asn Gly Thr Asn Ser Lys
    690                 695                 700                 
Ser Val Val Ala Gln Ile Pro Pro Ala Thr Ser Asn Gly Ser Ser Ser
705                 710                 715                 720 
Lys Thr Thr Asn Leu Pro Thr Ser Val Thr Ala Thr Lys Gly Ser Leu
                725                 730                 735     
Val Gly Leu Val Asp Tyr Pro Asp Asp Glu Glu Glu Asp Glu Glu Glu
            740                 745                 750         
Glu Ser Ser Pro Arg Lys Arg Pro Arg Leu Gly Ser
        755                 760                 


<210> 8140
<211> 611
<212> PRT
<213> Homo sapiens

<400> 8140
Ser Ile Pro Lys Met Glu Val Lys Ser Tyr Thr Lys Asn Asn Thr Ile
 1               5                  10                  15      
Ala Pro Lys Lys Ala Ser His Arg Ile Leu Ser Asp Thr Ser Asp Glu
            20                  25                  30          
Glu Asp Ala Ser Val Thr Val Gly Thr Gly Glu Lys Leu Arg Leu Ser
        35                  40                  45              
Ala His Thr Ile Leu Pro Gly Ser Lys Thr Arg Glu Pro Ser Asn Ala
    50                  55                  60                  
Lys Gln Gln Lys Glu Lys Asn Lys Val Lys Lys Lys Arg Lys Lys Glu
65                  70                  75                  80  
Thr Lys Gly Arg Glu Val Arg Phe Gly Lys Arg Ser Asp Lys Phe Cys
                85                  90                  95      
Ser Ser Glu Ser Glu Ser Glu Ser Ser Glu Ser Gly Glu Asp Asp Arg
            100                 105                 110         
Asp Ser Leu Gly Ser Ser Gly Cys Leu Lys Gly Ser Pro Leu Val Leu
        115                 120                 125             
Lys Asp Pro Ser Leu Phe Ser Ser Leu Ser Ala Ser Ser Thr Ser Ser
    130                 135                 140                 
His Gly Ser Ser Ala Ala Gln Lys Gln Asn Pro Ser His Thr Asp Gln
145                 150                 155                 160 
His Thr Lys His Trp Arg Thr Asp Asn Trp Lys Thr Ile Ser Ser Pro
                165                 170                 175     
Ala Trp Ser Glu Val Ser Ser Leu Ser Asp Ser Thr Arg Thr Arg Leu
            180                 185                 190         
Thr Ser Glu Ser Asp Tyr Ser Ser Glu Gly Ser Ser Val Glu Ser Leu
        195                 200                 205             
Lys Pro Val Arg Lys Arg Gln Glu His Arg Lys Arg Ala Ser Leu Ser
    210                 215                 220                 
Glu Lys Lys Ser Pro Phe Leu Ser Ser Ala Glu Gly Ala Val Pro Lys
225                 230                 235                 240 
Leu Asp Lys Glu Gly Lys Val Val Lys Lys His Lys Thr Lys His Lys
                245                 250                 255     
His Lys Asn Lys Glu Lys Gly Gln Cys Ser Ile Ser Gln Glu Leu Lys
            260                 265                 270         
Leu Lys Ser Phe Thr Tyr Glu Tyr Glu Asp Ser Lys Gln Lys Ser Asp
        275                 280                 285             
Lys Ala Ile Leu Leu Glu Asn Asp Leu Ser Thr Glu Asn Lys Leu Lys
    290                 295                 300                 
Val Leu Lys His Asp Arg Asp His Phe Lys Lys Glu Glu Lys Leu Ser
305                 310                 315                 320 
Lys Met Lys Leu Glu Glu Lys Glu Trp Leu Phe Lys Asp Glu Lys Ser
                325                 330                 335     
Leu Lys Arg Ile Lys Asp Thr Asn Lys Asp Ile Ser Arg Ser Phe Arg
            340                 345                 350         
Glu Glu Lys Asp Arg Ser Asn Lys Ala Glu Lys Glu Arg Ser Leu Lys
        355                 360                 365             
Glu Lys Ser Pro Lys Glu Glu Lys Leu Arg Leu Tyr Lys Glu Glu Arg
    370                 375                 380                 
Lys Lys Lys Ser Lys Asp Arg Pro Ser Lys Leu Glu Lys Lys Asn Asp
385                 390                 395                 400 
Leu Lys Glu Asp Lys Ile Ser Lys Glu Lys Glu Lys Ile Phe Lys Glu
                405                 410                 415     
Asp Lys Glu Lys Leu Lys Lys Glu Lys Val Tyr Arg Glu Asp Ser Ala
            420                 425                 430         
Phe Asp Glu Tyr Cys Asn Lys Asn Gln Phe Leu Glu Asn Glu Asp Thr
        435                 440                 445             
Lys Phe Ser Leu Ser Asp Asp Gln Arg Asp Arg Trp Phe Ser Asp Leu
    450                 455                 460                 
Ser Asp Ser Ser Phe Asp Phe Lys Gly Glu Asp Ser Trp Asp Ser Pro
465                 470                 475                 480 
Val Thr Asp Tyr Arg Asp Met Lys Ser Asp Ser Val Ala Lys Leu Ile
                485                 490                 495     
Leu Glu Thr Val Lys Glu Asp Ser Lys Glu Arg Arg Arg Asp Ser Arg
            500                 505                 510         
Ala Arg Glu Lys Arg Asp Tyr Arg Glu Pro Phe Phe Arg Lys Lys Asp
        515                 520                 525             
Arg Asp Tyr Leu Asp Lys Asn Ser Glu Lys Arg Lys Glu Gln Thr Glu
    530                 535                 540                 
Lys His Lys Ser Val Pro Gly Tyr Leu Ser Glu Lys Asp Glu Arg Arg
545                 550                 555                 560 
Arg Arg Arg Met Ala Pro Ile Arg Lys Gly Arg Arg Arg Gln Asn Gln
                565                 570                 575     
Lys Asp Thr Lys Arg Asn Pro Val Thr Arg Thr Lys Val Arg Asn Gln
            580                 585                 590         
Ser Trp Lys Asn Val Arg Arg Thr Lys Asn Leu Ile Asn Val Leu Lys
        595                 600                 605             
Arg Lys Lys
    610     


<210> 8141
<211> 290
<212> PRT
<213> Homo sapiens

<400> 8141
Met Phe Arg Leu Leu Ser Ser Cys Cys Ser Cys Leu Arg Thr Thr Glu
 1               5                  10                  15      
Glu Thr Arg Arg Asn Val Thr Ile Pro Ile Ile Gly Leu Asn Asn Ser
            20                  25                  30          
Gly Lys Thr Val Leu Val Glu Ala Phe Gln Lys Leu Leu Pro Ser Lys
        35                  40                  45              
Thr Asp His Cys Met Lys Ser Glu Leu Thr Thr Leu Leu Leu Asp Glu
    50                  55                  60                  
Tyr Glu Leu Ser Ile Tyr Asp Leu Asn Gly Asp Leu Lys Gly Arg Glu
65                  70                  75                  80  
Ala Trp Pro Asn Tyr Tyr Ala Gln Ala His Gly Leu Val Phe Val Leu
                85                  90                  95      
Asp Ser Ser Asp Ile Arg Arg Met Gln Glu Val Lys Ile Ile Leu Thr
            100                 105                 110         
His Leu Leu Ser Asp Lys Arg Val Ala Gly Lys Pro Ile Leu Ile Leu
        115                 120                 125             
Ala Asn Lys Gln Asp Lys Lys Lys Ala Leu Met Pro Cys Asp Ile Ile
    130                 135                 140                 
Asp Tyr Leu Leu Leu Lys Lys Leu Val Lys Glu Asn Lys Cys Pro Cys
145                 150                 155                 160 
Arg Val Glu Pro Cys Ser Ala Ile Arg Asn Leu Glu Arg Arg Asn His
                165                 170                 175     
Gln Pro Ile Val Glu Gly Leu Arg Trp Leu Leu Ala Val Ile Asp Thr
            180                 185                 190         
Cys Gln Leu Pro Pro Thr Ser Ser Ile Ser Ile Ser Lys Asn Asn Thr
        195                 200                 205             
Gly Ser Gly Glu Arg Cys Ser Ser His Ser Phe Ser Thr Arg Thr Gly
    210                 215                 220                 
Met Ser Lys Glu Lys Arg Gln His Leu Glu Gln Cys Ser Ile Glu Ala
225                 230                 235                 240 
Lys Pro Leu Lys Ser Ile Leu Gln Lys Glu Gly Thr Arg Leu Trp Ser
                245                 250                 255     
Lys Lys Asn Met Ser Val Thr Phe Ala Leu Asp Glu Pro Met Lys Glu
            260                 265                 270         
Gly Glu Cys Ser Arg Arg Met Arg Ala Gln Asn Thr Thr Lys Leu Cys
        275                 280                 285             
Tyr Asn
    290 


<210> 8142
<211> 1275
<212> PRT
<213> Homo sapiens

<400> 8142
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Asn Ile Asn
 1               5                  10                  15      
Gly Leu Asn Ser Ala Ile Lys Arg His Arg Leu Ala Ser Trp Ile Lys
            20                  25                  30          
Ser Gln Asp Pro Ser Val Cys Cys Ile Gln Glu Thr His Leu Thr Cys
        35                  40                  45              
Arg Asp Thr His Arg Leu Lys Ile Lys Gly Trp Arg Lys Ile Tyr Gln
    50                  55                  60                  
Ala Asn Gly Lys Gln Lys Lys Ala Gly Val Ala Ile Leu Val Ser Asp
65                  70                  75                  80  
Lys Thr Asp Phe Lys Pro Thr Lys Ile Lys Arg Asp Lys Glu Gly His
                85                  90                  95      
Tyr Ile Met Val Lys Gly Ser Ile Gln Gln Glu Glu Leu Thr Ile Leu
            100                 105                 110         
Asn Ile Tyr Ala Pro Asn Thr Gly Ala Pro Arg Phe Ile Lys Gln Val
        115                 120                 125             
Leu Ser Asp Leu Gln Arg Asp Leu Asp Ser His Thr Leu Ile Met Gly
    130                 135                 140                 
Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg Gln Lys
145                 150                 155                 160 
Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln Ala Asp
                165                 170                 175     
Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu Tyr Thr
            180                 185                 190         
Phe Phe Ser Ala Pro His His Thr Tyr Ser Lys Ile Asp His Ile Val
        195                 200                 205             
Gly Ser Lys Ala Leu Leu Ser Lys Cys Lys Arg Thr Glu Ile Ile Thr
    210                 215                 220                 
Asn Tyr Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys
225                 230                 235                 240 
Asn Leu Thr Gln Ser His Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu
                245                 250                 255     
Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala Glu Ile Lys Met
            260                 265                 270         
Phe Phe Glu Thr Asn Glu Asn Lys Asp Thr Thr Tyr Gln Asn Leu Trp
        275                 280                 285             
Asp Ala Phe Lys Ala Val Cys Arg Gly Lys Phe Ile Ala Leu Asn Ala
    290                 295                 300                 
Tyr Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln
305                 310                 315                 320 
Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg
                325                 330                 335     
Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr
            340                 345                 350         
Gln Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu
        355                 360                 365             
Arg Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys
    370                 375                 380                 
Arg Glu Lys Asn Gln Ile Asp Thr Val Lys Asn Asp Lys Gly Asp Ile
385                 390                 395                 400 
Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys
                405                 410                 415     
His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Thr Phe
            420                 425                 430         
Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser
        435                 440                 445             
Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn Ser
    450                 455                 460                 
Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe
465                 470                 475                 480 
Tyr Gln Arg Tyr Met Glu Glu Leu Val Pro Phe Leu Leu Lys Leu Phe
                485                 490                 495     
Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala
            500                 505                 510         
Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg Asp Thr Thr Lys Lys Glu
        515                 520                 525             
Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Asn
    530                 535                 540                 
Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys Lys Leu Ile His
545                 550                 555                 560 
His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile
                565                 570                 575     
Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Lys Asp Lys
            580                 585                 590         
Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile
        595                 600                 605             
Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly
    610                 615                 620                 
Thr Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Tyr Lys Pro Thr Ala Asn
625                 630                 635                 640 
Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly
                645                 650                 655     
Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu
            660                 665                 670         
Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile
        675                 680                 685             
Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met
    690                 695                 700                 
Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys
705                 710                 715                 720 
Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln
                725                 730                 735     
Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln
            740                 745                 750         
Ile Met Gly Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr
        755                 760                 765             
Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn
    770                 775                 780                 
Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys
785                 790                 795                 800 
Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala
                805                 810                 815     
Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu
            820                 825                 830         
Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile
        835                 840                 845             
Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile Leu Ser Gln Lys
    850                 855                 860                 
Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys
865                 870                 875                 880 
Pro Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Ile
                885                 890                 895     
Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Met Pro His Ile Tyr
            900                 905                 910         
Asn Tyr Leu Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln Trp Gly Lys
        915                 920                 925             
Asp Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Trp Leu Ala Ile Cys
    930                 935                 940                 
Arg Lys Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr Lys Ile Asn
945                 950                 955                 960 
Ser Arg Trp Ile Lys Asp Leu Asn Val Lys Pro Lys Thr Ile Lys Thr
                965                 970                 975     
Leu Glu Glu Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly Val Gly Lys
            980                 985                 990         
Asp Phe Met Ser Lys Thr Pro Lys Ala Met Ala Thr Lys Asp Lys Ile
        995                 1000                1005            
Asp Lys Trp Asp Leu Ile Lys Leu Lys Ser Phe Cys Thr Ala Lys Glu
    1010                1015                1020                
Thr Thr Ile Arg Val Asn Arg Gln Pro Thr Thr Trp Glu Lys Ile Phe
1025                1030                1035                1040
Ala Thr Tyr Ser Ser Asp Lys Gly Leu Ile Ser Arg Ile Tyr Asn Glu
                1045                1050                1055    
Leu Lys Gln Ile Tyr Lys Lys Lys Thr Asn Asn Pro Ile Lys Lys Trp
            1060                1065                1070        
Ala Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp Ile Tyr Ala Ala
        1075                1080                1085            
Lys Lys His Met Lys Lys Cys Ser Ser Ser Leu Ala Ile Arg Glu Met
    1090                1095                1100                
Gln Ile Lys Thr Thr Met Arg Tyr His Leu Thr Pro Val Arg Met Ala
1105                1110                1115                1120
Ile Ile Lys Lys Ser Gly Asn Asn Arg Cys Trp Arg Gly Cys Gly Glu
                1125                1130                1135    
Ile Gly Thr Leu Leu His Cys Trp Trp Asp Cys Lys Leu Val Gln Pro
            1140                1145                1150        
Leu Trp Lys Ser Val Trp Arg Phe Leu Arg Asp Leu Glu Leu Glu Ile
        1155                1160                1165            
Pro Phe Asp Pro Ala Ile Pro Leu Leu Gly Ile Tyr Pro Asn Glu Tyr
    1170                1175                1180                
Lys Ser Cys Cys Tyr Lys Asp Thr Cys Thr Arg Met Phe Ile Ala Ala
1185                1190                1195                1200
Leu Phe Thr Ile Ala Lys Thr Trp Asn Gln Pro Lys Cys Pro Thr Met
                1205                1210                1215    
Ile Asp Trp Ile Lys Lys Met Trp His Ile Tyr Thr Met Glu Tyr Tyr
            1220                1225                1230        
Ala Ala Ile Lys Asn Asp Glu Phe Ile Ser Phe Val Gly Thr Trp Met
        1235                1240                1245            
Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Glu Gln Lys Thr
    1250                1255                1260                
Lys His Arg Ile Phe Ser Leu Ile Gly Gly Asn
1265                1270                1275


<210> 8143
<211> 1275
<212> PRT
<213> Homo sapiens

<400> 8143
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Asn Ile Asn
 1               5                  10                  15      
Gly Leu Asn Ser Ala Ile Lys Arg His Arg Leu Ala Ser Trp Ile Lys
            20                  25                  30          
Ser Gln Asp Pro Ser Val Cys Cys Ile Gln Glu Thr His Leu Thr Cys
        35                  40                  45              
Arg Asp Thr His Arg Leu Lys Ile Lys Gly Trp Arg Lys Ile Tyr Gln
    50                  55                  60                  
Ala Asn Gly Lys Gln Lys Lys Ala Gly Val Ala Ile Leu Val Ser Asp
65                  70                  75                  80  
Lys Thr Asp Phe Lys Pro Thr Lys Ile Lys Arg Asp Lys Glu Gly His
                85                  90                  95      
Tyr Ile Met Val Lys Gly Ser Ile Gln Gln Glu Glu Leu Thr Ile Leu
            100                 105                 110         
Asn Ile Tyr Ala Pro Asn Thr Gly Ala Pro Arg Phe Ile Lys Gln Val
        115                 120                 125             
Leu Ser Asp Leu Gln Arg Asp Leu Asp Ser His Thr Leu Ile Met Gly
    130                 135                 140                 
Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg Gln Lys
145                 150                 155                 160 
Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln Ala Asp
                165                 170                 175     
Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu Tyr Thr
            180                 185                 190         
Phe Phe Ser Ala Pro His His Thr Tyr Ser Lys Ile Asp His Ile Val
        195                 200                 205             
Gly Ser Lys Ala Leu Leu Ser Lys Cys Lys Arg Thr Glu Ile Ile Thr
    210                 215                 220                 
Asn Tyr Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys
225                 230                 235                 240 
Asn Leu Thr Gln Ser His Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu
                245                 250                 255     
Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala Glu Ile Lys Met
            260                 265                 270         
Phe Phe Glu Thr Asn Glu Asn Asn Asp Thr Thr Tyr Gln Asn Leu Trp
        275                 280                 285             
Asp Ala Phe Lys Ala Val Cys Arg Gly Lys Phe Ile Ala Leu Asn Ala
    290                 295                 300                 
Tyr Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln
305                 310                 315                 320 
Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg
                325                 330                 335     
Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr
            340                 345                 350         
Gln Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu
        355                 360                 365             
Arg Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys
    370                 375                 380                 
Arg Glu Lys Asn Gln Ile Asp Thr Ile Lys Asn Asp Lys Gly Asp Ile
385                 390                 395                 400 
Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys
                405                 410                 415     
His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Thr Phe
            420                 425                 430         
Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser
        435                 440                 445             
Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn Ser
    450                 455                 460                 
Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe
465                 470                 475                 480 
Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu Leu Lys Leu Phe
                485                 490                 495     
Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala
            500                 505                 510         
Ser Ile Ile Leu Ile Pro Lys Pro Gly Arg Asp Thr Thr Lys Lys Glu
        515                 520                 525             
Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Asn
    530                 535                 540                 
Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys Lys Leu Ile His
545                 550                 555                 560 
His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile
                565                 570                 575     
Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Lys Asp Lys
            580                 585                 590         
Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile
        595                 600                 605             
Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly
    610                 615                 620                 
Thr Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro Thr Ala Asn
625                 630                 635                 640 
Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly
                645                 650                 655     
Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu
            660                 665                 670         
Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile
        675                 680                 685             
Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met
    690                 695                 700                 
Ile Val Tyr Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys
705                 710                 715                 720 
Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln
                725                 730                 735     
Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln
            740                 745                 750         
Ile Met Gly Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr
        755                 760                 765             
Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn
    770                 775                 780                 
Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys
785                 790                 795                 800 
Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala
                805                 810                 815     
Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu
            820                 825                 830         
Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Ile
        835                 840                 845             
Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile Leu Ser Gln Lys
    850                 855                 860                 
Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys
865                 870                 875                 880 
Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Ile
                885                 890                 895     
Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Met Pro His Ile Tyr
            900                 905                 910         
Asn Tyr Leu Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln Trp Gly Lys
        915                 920                 925             
Asp Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Trp Leu Ala Ile Cys
    930                 935                 940                 
Thr Lys Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr Lys Ile Asn
945                 950                 955                 960 
Ser Arg Trp Ile Lys Asp Leu Asn Val Arg Pro Lys Thr Ile Lys Thr
                965                 970                 975     
Leu Glu Glu Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly Val Gly Lys
            980                 985                 990         
Asp Phe Met Ser Lys Thr Pro Lys Ala Met Ala Thr Lys Val Lys Ile
        995                 1000                1005            
Asp Lys Trp Asp Leu Ile Lys Leu Lys Ser Phe Cys Thr Ala Lys Glu
    1010                1015                1020                
Thr Thr Ile Arg Val Asn Arg Gln Pro Thr Thr Trp Glu Lys Ile Phe
1025                1030                1035                1040
Ala Thr Tyr Ser Ser Asp Lys Gly Leu Ile Ser Arg Ile Tyr Asn Glu
                1045                1050                1055    
Leu Lys Gln Ile Tyr Lys Lys Lys Thr Asn Asn Pro Ile Lys Lys Trp
            1060                1065                1070        
Ala Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp Ile Tyr Ala Ala
        1075                1080                1085            
Lys Lys His Met Lys Lys Cys Ser Ser Ser Leu Ala Ile Arg Glu Met
    1090                1095                1100                
Gln Ile Lys Thr Thr Met Arg Tyr His Leu Thr Pro Val Arg Met Ala
1105                1110                1115                1120
Ile Ile Lys Lys Ser Gly Asn Asn Arg Cys Trp Arg Gly Cys Gly Glu
                1125                1130                1135    
Ile Gly Thr Leu Leu His Cys Trp Trp Asp Cys Lys Leu Val Gln Pro
            1140                1145                1150        
Leu Trp Lys Ser Val Trp Arg Phe Leu Arg Asp Leu Glu Leu Glu Ile
        1155                1160                1165            
Pro Phe Asp Pro Ala Ile Pro Leu Leu Gly Ile Tyr Pro Asn Glu Tyr
    1170                1175                1180                
Lys Ser Cys Cys Tyr Lys Asp Thr Cys Thr Arg Met Phe Ile Val Ala
1185                1190                1195                1200
Leu Phe Thr Ile Ala Lys Thr Trp Asn Gln Leu Lys Cys Pro Thr Met
                1205                1210                1215    
Ile Asp Trp Ile Lys Lys Met Trp His Ile Tyr Thr Met Glu Tyr Tyr
            1220                1225                1230        
Ala Ala Ile Lys Asn Asp Glu Phe Ile Ser Phe Val Gly Thr Trp Met
        1235                1240                1245            
Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Glu Gln Lys Thr
    1250                1255                1260                
Lys His Arg Ile Phe Ser Leu Ile Gly Gly Asn
1265                1270                1275


<210> 8144
<211> 1275
<212> PRT
<213> Homo sapiens

<400> 8144
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Asn Ile Asn
 1               5                  10                  15      
Gly Leu Asn Ser Ala Ile Lys Arg His Arg Leu Ala Ser Trp Ile Lys
            20                  25                  30          
Ser Gln Asp Pro Ser Val Cys Cys Ile Gln Glu Thr His Leu Thr Cys
        35                  40                  45              
Arg Asp Thr His Arg Leu Lys Ile Lys Gly Trp Arg Lys Ile Tyr Gln
    50                  55                  60                  
Ala Asn Gly Lys Gln Lys Lys Ala Gly Val Ala Ile Leu Val Ser Asp
65                  70                  75                  80  
Lys Thr Asp Phe Lys Pro Thr Lys Ile Lys Arg Asp Lys Glu Gly His
                85                  90                  95      
Tyr Ile Met Val Lys Gly Ser Ile Gln Gln Glu Glu Leu Thr Ile Leu
            100                 105                 110         
Asn Ile Tyr Ala Pro Asn Thr Gly Ala Pro Arg Phe Ile Lys Gln Val
        115                 120                 125             
Leu Ser Asp Leu Gln Arg Asp Leu Asp Ser His Thr Leu Ile Met Gly
    130                 135                 140                 
Asp Phe Asn Thr Pro Leu Ser Thr Leu Asp Arg Ser Thr Arg Gln Lys
145                 150                 155                 160 
Val Asn Lys Asp Thr Gln Glu Leu Asn Ser Ala Leu His Gln Ala Asp
                165                 170                 175     
Leu Ile Asp Ile Tyr Arg Thr Leu His Pro Lys Ser Thr Glu Tyr Thr
            180                 185                 190         
Phe Phe Ser Ala Pro His His Thr Tyr Ser Lys Ile Asp His Arg Val
        195                 200                 205             
Gly Ser Lys Ala Leu Leu Ser Lys Cys Lys Arg Thr Glu Ile Ile Thr
    210                 215                 220                 
Asn Tyr Leu Ser Asp His Ser Ala Ile Lys Leu Glu Leu Arg Ile Lys
225                 230                 235                 240 
Asn Leu Thr Gln Ser His Ser Thr Thr Trp Lys Leu Asn Asn Leu Leu
                245                 250                 255     
Leu Asn Asp Tyr Trp Val His Asn Glu Met Lys Ala Glu Ile Lys Met
            260                 265                 270         
Phe Phe Glu Thr Asn Glu Asn Asn Asp Thr Thr Tyr Gln Asn Leu Trp
        275                 280                 285             
Asp Ala Phe Lys Ala Val Cys Arg Gly Lys Phe Ile Ala Leu Asn Ala
    290                 295                 300                 
Tyr Lys Arg Lys Gln Glu Arg Ser Lys Ile Asp Thr Leu Thr Ser Gln
305                 310                 315                 320 
Leu Lys Glu Leu Glu Lys Gln Glu Gln Thr His Ser Lys Ala Ser Arg
                325                 330                 335     
Arg Gln Glu Ile Thr Lys Ile Arg Ala Glu Leu Lys Glu Ile Glu Thr
            340                 345                 350         
Gln Lys Thr Leu Gln Lys Ile Asn Glu Ser Arg Ser Trp Phe Phe Glu
        355                 360                 365             
Arg Ile Asn Lys Ile Asp Arg Pro Leu Ala Arg Leu Ile Lys Lys Lys
    370                 375                 380                 
Arg Glu Lys Asn Gln Ile Asp Thr Ile Lys Ile Asp Lys Gly Asp Ile
385                 390                 395                 400 
Thr Thr Asp Pro Thr Glu Ile Gln Thr Thr Ile Arg Glu Tyr Tyr Lys
                405                 410                 415     
His Leu Tyr Ala Asn Lys Leu Glu Asn Leu Glu Glu Met Asp Thr Phe
            420                 425                 430         
Leu Asp Thr Tyr Thr Leu Pro Arg Leu Asn Gln Glu Glu Val Glu Ser
        435                 440                 445             
Leu Asn Arg Pro Ile Thr Gly Ser Glu Ile Val Ala Ile Ile Asn Ser
    450                 455                 460                 
Leu Pro Thr Lys Lys Ser Pro Gly Pro Asp Gly Phe Thr Ala Glu Phe
465                 470                 475                 480 
Tyr Gln Arg Tyr Lys Glu Glu Leu Val Pro Phe Leu Leu Lys Leu Phe
                485                 490                 495     
Gln Ser Ile Glu Lys Glu Gly Ile Leu Pro Asn Ser Phe Tyr Glu Ala
            500                 505                 510         
Ser Ile Ile Leu Ile Pro Lys Leu Gly Arg Asp Thr Thr Lys Lys Glu
        515                 520                 525             
Asn Phe Arg Pro Ile Ser Leu Met Asn Ile Asp Ala Lys Ile Leu Thr
    530                 535                 540                 
Lys Ile Leu Ala Asn Arg Ile Gln Gln His Ile Lys Lys Leu Ile His
545                 550                 555                 560 
His Asp Gln Val Gly Phe Ile Pro Gly Met Gln Gly Trp Phe Asn Ile
                565                 570                 575     
Arg Lys Ser Ile Asn Val Ile Gln His Ile Asn Arg Ala Lys Asp Lys
            580                 585                 590         
Asn His Met Ile Ile Ser Ile Asp Ala Glu Lys Ala Phe Asp Lys Ile
        595                 600                 605             
Gln Gln Pro Phe Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Asp Gly
    610                 615                 620                 
Thr Tyr Phe Lys Ile Ile Arg Ala Ile Tyr Asp Lys Pro Thr Ala Asn
625                 630                 635                 640 
Ile Ile Leu Asn Gly Gln Lys Leu Glu Ala Phe Pro Leu Lys Thr Gly
                645                 650                 655     
Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu
            660                 665                 670         
Glu Val Leu Ala Arg Ala Ile Arg Gln Glu Lys Glu Ile Lys Gly Ile
        675                 680                 685             
Gln Leu Gly Lys Glu Glu Val Lys Leu Ser Leu Phe Ala Asp Asp Met
    690                 695                 700                 
Ile Val Cys Leu Glu Asn Pro Ile Val Ser Ala Gln Asn Leu Leu Lys
705                 710                 715                 720 
Leu Ile Ser Asn Phe Ser Lys Val Ser Gly Tyr Lys Ile Asn Val Gln
                725                 730                 735     
Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn Arg Gln Thr Glu Ser Gln
            740                 745                 750         
Ile Met Gly Glu Leu Pro Phe Thr Ile Ala Ser Lys Arg Ile Lys Tyr
        755                 760                 765             
Leu Gly Ile Gln Leu Thr Arg Asp Val Lys Asp Leu Phe Lys Glu Asn
    770                 775                 780                 
Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu Asp Thr Asn Lys Trp Lys
785                 790                 795                 800 
Asn Ile Pro Cys Ser Trp Val Gly Arg Ile Asn Ile Val Lys Met Ala
                805                 810                 815     
Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn Ala Ile Pro Ile Lys Leu
            820                 825                 830         
Pro Met Thr Phe Phe Thr Glu Leu Glu Lys Thr Thr Leu Lys Phe Met
        835                 840                 845             
Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys Ser Ile Leu Ser Gln Lys
    850                 855                 860                 
Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Tyr Tyr Lys
865                 870                 875                 880 
Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp Tyr Gln Asn Arg Asp Ile
                885                 890                 895     
Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu Ile Met Pro His Ile Tyr
            900                 905                 910         
Asn Tyr Leu Ile Phe Asp Lys Pro Glu Lys Asn Lys Gln Trp Gly Lys
        915                 920                 925             
Asp Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Trp Leu Ala Ile Cys
    930                 935                 940                 
Arg Arg Leu Lys Leu Asp Pro Phe Leu Thr Pro Tyr Thr Lys Ile Asn
945                 950                 955                 960 
Ser Arg Trp Ile Lys Asp Leu Asn Val Arg Pro Lys Thr Ile Lys Thr
                965                 970                 975     
Leu Glu Glu Asn Leu Gly Ile Thr Ile Gln Asp Ile Gly Val Gly Lys
            980                 985                 990         
Asp Phe Met Ser Lys Thr Pro Lys Ala Met Ala Thr Lys Ala Lys Ile
        995                 1000                1005            
Asp Lys Trp Asp Leu Ile Lys Leu Lys Ser Phe Cys Thr Ala Lys Glu
    1010                1015                1020                
Thr Thr Ile Arg Val Asn Arg Gln Pro Thr Thr Trp Glu Lys Ile Phe
1025                1030                1035                1040
Ala Thr Tyr Ser Ser Asp Lys Gly Leu Ile Ser Arg Ile Tyr Asn Glu
                1045                1050                1055    
Leu Lys Gln Ile Tyr Lys Lys Lys Thr Asn Asn Pro Ile Lys Lys Trp
            1060                1065                1070        
Ala Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp Ile Tyr Ala Ala
        1075                1080                1085            
Lys Lys His Met Lys Lys Cys Ser Ser Ser Leu Ala Ile Arg Glu Met
    1090                1095                1100                
Gln Ile Lys Thr Thr Met Arg Tyr His Leu Thr Pro Val Arg Met Ala
1105                1110                1115                1120
Ile Ile Lys Lys Ser Gly Asn Asn Arg Cys Trp Arg Gly Cys Gly Glu
                1125                1130                1135    
Ile Gly Thr Leu Leu His Cys Trp Trp Asp Cys Lys Leu Val Gln Pro
            1140                1145                1150        
Leu Trp Lys Ser Val Trp Arg Phe Leu Arg Asp Leu Glu Leu Glu Ile
        1155                1160                1165            
Pro Phe Asp Pro Ala Ile Pro Leu Leu Gly Ile Tyr Pro Asn Glu Tyr
    1170                1175                1180                
Lys Ser Cys Cys Tyr Lys Asp Thr Cys Thr Arg Met Phe Ile Ala Ala
1185                1190                1195                1200
Leu Phe Thr Ile Ala Lys Thr Trp Asn Gln Leu Lys Cys Pro Thr Met
                1205                1210                1215    
Ile Asp Trp Ile Lys Lys Met Trp His Ile Tyr Thr Met Glu Tyr Tyr
            1220                1225                1230        
Ala Ala Ile Lys Asn Asp Glu Phe Ile Ser Phe Val Gly Thr Trp Met
        1235                1240                1245            
Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu Ser Gln Glu Gln Lys Thr
    1250                1255                1260                
Lys His Arg Ile Phe Ser Leu Ile Ala Gly Asn
1265                1270                1275


<210> 8145
<211> 1064
<212> PRT
<213> Homo sapiens

<400> 8145
Met Ala Ser Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr
 1               5                  10                  15      
Phe Tyr Pro Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala
            20                  25                  30          
Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val
        35                  40                  45              
Pro Pro Lys Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp
    50                  55                  60                  
Leu Val Ile Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly
65                  70                  75                  80  
Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu
                85                  90                  95      
Phe Arg Lys Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser
            100                 105                 110         
Glu Phe Glu Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn
        115                 120                 125             
Pro Pro Ile Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His
    130                 135                 140                 
Val Asp Glu Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val
145                 150                 155                 160 
Glu Lys Glu Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu
                165                 170                 175     
Tyr Phe Gly Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met
            180                 185                 190         
Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp
        195                 200                 205             
Tyr Ser Val Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys
    210                 215                 220                 
Gly Phe Phe Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His
225                 230                 235                 240 
Lys Met Thr Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro
                245                 250                 255     
Phe Asp Lys Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro
            260                 265                 270         
Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser
        275                 280                 285             
Thr Asn Phe Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val
    290                 295                 300                 
Leu Cys Ser Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe
305                 310                 315                 320 
Val Arg Lys Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys
                325                 330                 335     
Asp Asn Thr Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala Ala Glu
            340                 345                 350         
Phe Leu Lys Glu Ser Glu Leu Pro Pro Arg Ala Gly Asn Glu Glu Glu
        355                 360                 365             
Cys Pro Glu Glu Asp Met Glu Gly Val Glu Asp Gly Glu Glu Gly Asp
    370                 375                 380                 
Leu Lys Thr Ser Leu Ala Lys His Arg Ile Gly Thr Lys Arg His Arg
385                 390                 395                 400 
Val Cys Leu Glu Ile Pro Gln Glu Val Ser Gln Ser Glu Leu Phe Pro
                405                 410                 415     
Lys Glu Asp Leu Ser Ser Glu Gln Tyr Glu Met Thr Glu Cys Pro Ala
            420                 425                 430         
Ala Leu Ala Pro Val Arg Pro Thr His Ser Ser Val Arg Gln Val Glu
        435                 440                 445             
Asp Gly Leu Thr Phe Pro Asp Tyr Ser Asp Ser Thr Glu Val Lys Phe
    450                 455                 460                 
Glu Glu Leu Lys Asn Val Lys Leu Glu Glu Glu Asp Glu Glu Glu Glu
465                 470                 475                 480 
Gln Glu Ala Ala Ala Leu Asp Leu Ser Val Asn Pro Ala Ser Val Gly
                485                 490                 495     
Gly Arg Leu Val Phe Ser Gly Ser Lys Lys Lys Ser Ser Ser Ser Leu
            500                 505                 510         
Gly Ser Gly Ser Ser Arg Asp Ser Ile Ser Ser Asp Ser Glu Thr Ser
        515                 520                 525             
Glu Pro Leu Ser Cys Arg Ala Gln Gly Gln Thr Gly Val Leu Thr Val
    530                 535                 540                 
His Ser Tyr Ala Lys Gly Asp Gly Arg Val Thr Val Gly Glu Pro Cys
545                 550                 555                 560 
Thr Arg Lys Lys Gly Ser Ala Ala Arg Ser Phe Ser Glu Arg Glu Leu
                565                 570                 575     
Ala Glu Val Ala Asp Glu Tyr Met Phe Ser Leu Glu Glu Asn Lys Lys
            580                 585                 590         
Ser Lys Gly Arg Arg Gln Pro Leu Ser Lys Leu Pro Arg His His Pro
        595                 600                 605             
Leu Val Leu Gln Glu Cys Val Ser Asp Asp Glu Thr Ser Glu Gln Leu
    610                 615                 620                 
Thr Pro Glu Glu Glu Ala Glu Glu Thr Glu Ala Trp Ala Lys Pro Leu
625                 630                 635                 640 
Ser Gln Leu Trp Gln Asn Arg Pro Pro Asn Phe Glu Ala Glu Lys Glu
                645                 650                 655     
Phe Asn Glu Thr Met Ala Gln Gln Ala Pro His Cys Ala Val Cys Met
            660                 665                 670         
Ile Phe Gln Thr Tyr His Gln Val Glu Phe Gly Gly Phe Asn Gln Asn
        675                 680                 685             
Cys Gly Asn Ala Ser Asp Leu Ala Pro Gln Lys Gln Arg Thr Lys Pro
    690                 695                 700                 
Leu Ile Pro Glu Met Cys Phe Thr Ser Thr Gly Cys Ser Thr Asp Ile
705                 710                 715                 720 
Asn Leu Ser Thr Pro Tyr Leu Glu Glu Asp Gly Thr Ser Ile Leu Val
                725                 730                 735     
Ser Cys Lys Lys Cys Ser Val Arg Val His Ala Ser Cys Tyr Gly Val
            740                 745                 750         
Pro Pro Ala Lys Ala Ser Glu Asp Trp Met Cys Ser Arg Cys Ser Ala
        755                 760                 765             
Asn Ala Leu Glu Glu Asp Cys Cys Leu Cys Ser Leu Arg Gly Gly Ala
    770                 775                 780                 
Leu Gln Arg Ala Asn Asp Asp Arg Trp Val His Val Ser Cys Ala Val
785                 790                 795                 800 
Ala Ile Leu Glu Ala Arg Phe Val Asn Ile Ala Glu Arg Ser Pro Val
                805                 810                 815     
Asp Val Ser Lys Ile Pro Leu Pro Arg Phe Lys Leu Lys Cys Ile Phe
            820                 825                 830         
Cys Lys Lys Arg Arg Lys Arg Thr Ala Gly Cys Cys Val Gln Cys Ser
        835                 840                 845             
His Gly Arg Cys Pro Thr Ala Phe His Val Ser Cys Ala Gln Ala Ala
    850                 855                 860                 
Gly Val Met Met Gln Pro Asp Asp Trp Pro Phe Val Val Phe Ile Thr
865                 870                 875                 880 
Cys Phe Arg His Lys Ile Pro Asn Leu Glu Arg Ala Lys Gly Ala Leu
                885                 890                 895     
Gln Ser Ile Thr Ala Gly Gln Lys Val Ile Ser Lys His Lys Asn Gly
            900                 905                 910         
Arg Phe Tyr Gln Cys Glu Val Val Arg Leu Thr Thr Glu Thr Phe Tyr
        915                 920                 925             
Glu Val Asn Phe Asp Asp Gly Ser Phe Ser Asp Asn Leu Tyr Pro Glu
    930                 935                 940                 
Asp Ile Val Ser Gln Asp Cys Leu Gln Phe Gly Pro Pro Ala Glu Gly
945                 950                 955                 960 
Glu Val Val Gln Val Arg Trp Thr Asp Gly Gln Val Tyr Gly Ala Lys
                965                 970                 975     
Phe Val Ala Ser His Pro Ile Gln Met Tyr Gln Val Glu Phe Glu Asp
            980                 985                 990         
Gly Ser Gln Leu Val Val Lys Arg Asp Asp Val Tyr Thr Leu Asp Glu
        995                 1000                1005            
Glu Leu Pro Lys Arg Val Lys Ser Arg Leu Ser Val Ala Ser Asp Met
    1010                1015                1020                
Arg Phe Asn Glu Ile Phe Thr Glu Lys Glu Val Lys Gln Glu Lys Lys
1025                1030                1035                1040
Arg Gln Arg Val Ile Asn Ser Arg Tyr Arg Glu Asp Tyr Ile Glu Pro
                1045                1050                1055    
Ala Leu Tyr Arg Ala Ile Met Glu
            1060                


<210> 8146
<211> 251
<212> PRT
<213> Homo sapiens

<400> 8146
Gln Cys Gln Lys Lys Glu Ile Glu Gln Met Cys Gln Asn Glu Gln Ser
 1               5                  10                  15      
Arg Val Asn Lys Tyr Thr Gly Val Glu Thr Tyr Glu Asp Arg Phe Ser
            20                  25                  30          
Gln Leu Gln Ser Glu Asn Asn Leu Leu Trp Gln Gln Leu Asp Asp Ala
        35                  40                  45              
Asp Lys Lys Ala Glu Ser Gln Glu Lys Thr Ile Ser Thr Ile Gln Glu
    50                  55                  60                  
Gln Phe His Ala Val Val Arg Asn Leu Leu Ala Glu Ser Ile Lys Leu
65                  70                  75                  80  
Leu Leu Glu Glu Glu Asn Glu Glu Ile Ile Asn Val Arg Asn Pro Leu
                85                  90                  95      
Lys Glu Arg Ile Tyr Gln Cys Glu Lys Glu Thr Val Gly Lys Lys Ile
            100                 105                 110         
Met Arg Gln Leu Leu Gln Glu Pro Ala Asp Thr Leu Lys Lys Asn Leu
        115                 120                 125             
Ser Glu Pro Ser Leu Glu Ala Thr Pro His Cys His Ile Asn Leu Glu
    130                 135                 140                 
Glu Thr Gln Asp Ser Lys Lys Glu Leu Ala Thr Ala Leu Ser Ser Cys
145                 150                 155                 160 
Ile Ile Ser Phe Met Gln Phe Asp Asp Leu Thr Ala Glu Leu Glu Ala
                165                 170                 175     
Val Ser Leu Gln Cys Val Tyr Leu Ala Glu Asn Asn Gln Val Thr Gln
            180                 185                 190         
Gln Glu Leu Ser Met Lys Lys Val Gln Gln Glu Cys Glu Lys Leu Glu
        195                 200                 205             
Glu Asn Lys Lys Met Leu Glu Glu Gly Ile Val Asn Leu Met Thr His
    210                 215                 220                 
Met Glu Asn Met Val Glu Leu Gly Lys Val Gln Glu Tyr Lys Leu Glu
225                 230                 235                 240 
Leu Glu Glu Lys Ala Met Pro Ala Ile Glu Lys
                245                 250     


<210> 8147
<211> 106
<212> PRT
<213> Homo sapiens

<400> 8147
Met Met Thr Leu Val Pro Arg Ala Arg Thr Arg Ala Gly Gln Asp His
 1               5                  10                  15      
Tyr Ser His Pro Cys Pro Arg Phe Ser Gln Val Leu Leu Thr Glu Gly
            20                  25                  30          
Ile Met Thr Tyr Cys Leu Thr Lys Asn Leu Ser Asp Val Asn Ile Leu
        35                  40                  45              
His Arg Leu Leu Lys Asn Gly Asn Val Arg Asn Thr Leu Leu Gln Ser
    50                  55                  60                  
Lys Val Gly Leu Leu Thr Tyr Tyr Val Lys Leu Tyr Pro Gly Glu Val
65                  70                  75                  80  
Thr Leu Leu Thr Arg Pro Ser Ile Gln Met Arg Leu Cys Cys Ile Thr
                85                  90                  95      
Gly Ser Val Ser Lys Pro Arg Ser Gln Lys
            100                 105     


<210> 8148
<211> 677
<212> PRT
<213> Homo sapiens

<400> 8148
Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly
 1               5                  10                  15      
Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys
            20                  25                  30          
Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg
        35                  40                  45              
His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr
    50                  55                  60                  
Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg
65                  70                  75                  80  
Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile
                85                  90                  95      
Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu
            100                 105                 110         
Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile
        115                 120                 125             
Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys
    130                 135                 140                 
Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys
145                 150                 155                 160 
Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile
                165                 170                 175     
Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly
            180                 185                 190         
Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn
        195                 200                 205             
Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr
    210                 215                 220                 
Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly
225                 230                 235                 240 
Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu
                245                 250                 255     
Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala
            260                 265                 270         
Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg
        275                 280                 285             
Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His
    290                 295                 300                 
Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys
305                 310                 315                 320 
Lys Asp Cys Pro Val Ser Asn Ile Asn Lys Cys Cys Lys Gln Leu Leu
                325                 330                 335     
Arg His Gly Ala Leu Leu Thr Glu Ile Leu Leu Phe Leu Gln Leu Phe
            340                 345                 350         
Leu Asn Arg Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln Ile
        355                 360                 365             
Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile Ala
    370                 375                 380                 
Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro Ser
385                 390                 395                 400 
Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala Pro
                405                 410                 415     
Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly Asn
            420                 425                 430         
Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro Gln
        435                 440                 445             
Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu Gln
    450                 455                 460                 
Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln Gln
465                 470                 475                 480 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
                485                 490                 495     
Gln Gln Gln Gln Gln His His His His His His His His Leu Leu Gln
            500                 505                 510         
Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln Met
        515                 520                 525             
Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro Ser
    530                 535                 540                 
Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe Phe
545                 550                 555                 560 
Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala Ser
                565                 570                 575     
Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val Ser
            580                 585                 590         
Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser Ser
        595                 600                 605             
Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn Phe
    610                 615                 620                 
Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp Asn
625                 630                 635                 640 
Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu Leu
                645                 650                 655     
Asp Arg Glu Phe Asp Leu Leu Arg Ser Ser Lys Gly His Leu Lys Ala
            660                 665                 670         
Tyr Phe Ala Ser Gln
        675         


<210> 8149
<211> 662
<212> PRT
<213> Homo sapiens

<400> 8149
Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly
 1               5                  10                  15      
Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys
            20                  25                  30          
Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg
        35                  40                  45              
His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr
    50                  55                  60                  
Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg
65                  70                  75                  80  
Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile
                85                  90                  95      
Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu
            100                 105                 110         
Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile
        115                 120                 125             
Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys
    130                 135                 140                 
Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys
145                 150                 155                 160 
Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile
                165                 170                 175     
Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly
            180                 185                 190         
Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn
        195                 200                 205             
Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr
    210                 215                 220                 
Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly
225                 230                 235                 240 
Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu
                245                 250                 255     
Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala
            260                 265                 270         
Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg
        275                 280                 285             
Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His
    290                 295                 300                 
Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys
305                 310                 315                 320 
Lys Asp Cys Pro Val Ser Asn Ile Asn Asn Ser Ser Ile Pro Ser Ala
                325                 330                 335     
Leu Pro Glu Pro Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln
            340                 345                 350         
Ile Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile
        355                 360                 365             
Ala Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro
    370                 375                 380                 
Ser Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala
385                 390                 395                 400 
Pro Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly
                405                 410                 415     
Asn Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro
            420                 425                 430         
Gln Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu
        435                 440                 445             
Gln Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln
    450                 455                 460                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
465                 470                 475                 480 
Gln Gln Gln Gln Gln Gln His His His His His His His His Leu Leu
                485                 490                 495     
Gln Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln
            500                 505                 510         
Met Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro
        515                 520                 525             
Ser Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe
    530                 535                 540                 
Phe Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala
545                 550                 555                 560 
Ser Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val
                565                 570                 575     
Ser Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser
            580                 585                 590         
Ser Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn
        595                 600                 605             
Phe Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp
    610                 615                 620                 
Asn Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu
625                 630                 635                 640 
Leu Asp Arg Glu Phe Asp Leu Leu Arg Ser Ser Lys Gly His Leu Lys
                645                 650                 655     
Ala Tyr Phe Ala Ser Gln
            660         


<210> 8150
<211> 1161
<212> PRT
<213> Homo sapiens

<400> 8150
Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly
 1               5                  10                  15      
Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys
            20                  25                  30          
Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg
        35                  40                  45              
His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr
    50                  55                  60                  
Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg
65                  70                  75                  80  
Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile
                85                  90                  95      
Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu
            100                 105                 110         
Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile
        115                 120                 125             
Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys
    130                 135                 140                 
Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys
145                 150                 155                 160 
Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile
                165                 170                 175     
Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly
            180                 185                 190         
Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn
        195                 200                 205             
Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr
    210                 215                 220                 
Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly
225                 230                 235                 240 
Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu
                245                 250                 255     
Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala
            260                 265                 270         
Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg
        275                 280                 285             
Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His
    290                 295                 300                 
Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys
305                 310                 315                 320 
Lys Asp Cys Pro Val Ser Asn Ile Asn Asn Ser Ser Ile Pro Ser Ala
                325                 330                 335     
Leu Pro Glu Pro Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln
            340                 345                 350         
Ile Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile
        355                 360                 365             
Ala Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro
    370                 375                 380                 
Ser Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala
385                 390                 395                 400 
Pro Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly
                405                 410                 415     
Asn Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro
            420                 425                 430         
Gln Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu
        435                 440                 445             
Gln Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln
    450                 455                 460                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
465                 470                 475                 480 
Gln Gln Gln Gln Gln Gln His His His His His His His His Leu Leu
                485                 490                 495     
Gln Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln
            500                 505                 510         
Met Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro
        515                 520                 525             
Ser Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe
    530                 535                 540                 
Phe Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala
545                 550                 555                 560 
Ser Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val
                565                 570                 575     
Ser Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser
            580                 585                 590         
Ser Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn
        595                 600                 605             
Phe Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp
    610                 615                 620                 
Asn Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu
625                 630                 635                 640 
Leu Asp Arg Glu Phe Asp Leu Leu Arg Ser Asn Arg Leu Glu Glu Arg
                645                 650                 655     
Ala Ser Ser Asp Lys Asn Val Asp Ser Leu Ser Ala Pro His Asn His
            660                 665                 670         
Pro Pro Glu Asp Pro Phe Gly Ser Val Pro Phe Ile Ser His Ser Gly
        675                 680                 685             
Ser Pro Glu Lys Lys Ala Glu His Ser Ser Ile Asn Gln Glu Asn Gly
    690                 695                 700                 
Thr Ala Asn Pro Ile Lys Asn Gly Lys Thr Ser Pro Ala Ser Lys Asp
705                 710                 715                 720 
Gln Arg Thr Gly Lys Lys Thr Ser Val Gln Gly Gln Val Gln Lys Gly
                725                 730                 735     
Asn Asp Glu Ser Glu Ser Asp Phe Glu Ser Asp Pro Pro Ser Pro Lys
            740                 745                 750         
Ser Ser Glu Glu Glu Glu Gln Asp Asp Glu Glu Val Leu Gln Gly Glu
        755                 760                 765             
Gln Gly Asp Phe Asn Asp Asp Asp Thr Glu Pro Glu Asn Leu Gly His
    770                 775                 780                 
Arg Pro Leu Leu Met Asp Ser Glu Asp Glu Glu Glu Glu Glu Lys His
785                 790                 795                 800 
Ser Ser Asp Ser Asp Tyr Glu Gln Ala Lys Ala Lys Tyr Ser Asp Met
                805                 810                 815     
Ser Ser Val Tyr Arg Asp Arg Ser Gly Ser Gly Pro Thr Gln Asp Leu
            820                 825                 830         
Asn Thr Ile Leu Leu Thr Ser Ala Gln Leu Ser Ser Asp Val Ala Val
        835                 840                 845             
Glu Thr Pro Lys Gln Glu Phe Asp Val Phe Gly Ala Val Pro Phe Phe
    850                 855                 860                 
Ala Val Arg Ala Gln Gln Pro Gln Gln Glu Lys Asn Glu Lys Asn Leu
865                 870                 875                 880 
Pro Gln His Arg Phe Pro Ala Ala Gly Leu Glu Gln Glu Glu Phe Asp
                885                 890                 895     
Val Phe Thr Lys Ala Pro Phe Ser Lys Lys Val Asn Val Gln Glu Cys
            900                 905                 910         
His Ala Val Gly Pro Glu Ala His Thr Ile Pro Gly Tyr Pro Lys Ser
        915                 920                 925             
Val Asp Val Phe Gly Ser Thr Pro Phe Gln Pro Phe Leu Thr Ser Thr
    930                 935                 940                 
Ser Lys Ser Glu Ser Asn Glu Asp Leu Phe Gly Leu Val Pro Phe Asp
945                 950                 955                 960 
Glu Ile Thr Gly Ser Gln Gln Gln Lys Val Lys Gln Arg Ser Leu Gln
                965                 970                 975     
Lys Leu Ser Ser Arg Gln Arg Arg Thr Lys Gln Asp Met Ser Lys Ser
            980                 985                 990         
Asn Gly Lys Arg His His Gly Thr Pro Thr Ser Thr Lys Lys Thr Leu
        995                 1000                1005            
Lys Pro Thr Tyr Arg Thr Pro Glu Arg Ala Arg Arg His Lys Lys Val
    1010                1015                1020                
Gly Arg Arg Asp Ser Gln Ser Ser Asn Glu Phe Leu Thr Ile Ser Asp
1025                1030                1035                1040
Ser Lys Glu Asn Ile Ser Val Ala Leu Thr Asp Gly Lys Asp Arg Gly
                1045                1050                1055    
Asn Val Leu Gln Pro Glu Glu Ser Leu Leu Asp Pro Phe Gly Ala Lys
            1060                1065                1070        
Pro Phe His Ser Pro Asp Leu Ser Trp His Pro Pro His Gln Gly Leu
        1075                1080                1085            
Ser Asp Ile Arg Ala Asp His Asn Thr Val Leu Pro Gly Arg Pro Arg
    1090                1095                1100                
Gln Asn Ser Leu His Gly Ser Phe His Ser Ala Asp Val Leu Lys Met
1105                1110                1115                1120
Asp Asp Phe Gly Ala Val Pro Phe Thr Glu Leu Val Val Gln Ser Ile
                1125                1130                1135    
Thr Pro His Gln Ser Gln Gln Ser Gln Pro Val Glu Leu Asp Pro Phe
            1140                1145                1150        
Gly Ala Ala Pro Phe Pro Ser Lys Gln
        1155                1160    


<210> 8151
<211> 257
<212> PRT
<213> Homo sapiens

<400> 8151
Met Lys Arg Val Lys Arg Phe Leu Glu Lys Arg Glu Pro Lys Leu Asn
 1               5                  10                  15      
Glu Asn Ile Lys Asn Ala Met Leu Ile Lys Gly Gly Asn Ala Asn Ala
            20                  25                  30          
Thr Val Thr Gln Val Leu Lys Asp Val Cys Ala Leu Lys Lys Pro Tyr
        35                  40                  45              
Gly Val Leu Tyr Lys Lys Lys Asn Val Thr Arg Pro Phe Glu Asp Gln
    50                  55                  60                  
Thr Ser Leu Glu Leu Leu Ser Lys Lys Ser Asp Cys Ser Leu Phe Met
65                  70                  75                  80  
Phe Gly Ser Tyr Asn Lys Lys Arg Pro Asn Asn Leu Val Ile Gly His
                85                  90                  95      
Met Tyr Asp Tyr His Val Leu Asp Met Ile Glu Leu Gly Ile Glu Asn
            100                 105                 110         
Phe Val Ser Leu Lys Asp Ile Lys Asn Ser Lys Cys Pro Glu Gly Thr
        115                 120                 125             
Lys Pro Met Leu Ile Phe Ala Gly Asp Asp Phe Asn Val Thr Glu Asp
    130                 135                 140                 
Tyr Arg Arg Leu Lys Ser Leu Leu Thr Asp Phe Phe Arg Gly Pro Thr
145                 150                 155                 160 
Val Ser Asn Ile Cys Leu Ala Gly Leu Glu Tyr Val Leu His Phe Thr
                165                 170                 175     
Ala Leu Asn Gly Lys Ile Tyr Phe Arg Arg Tyr Lys Leu Leu Leu Lys
            180                 185                 190         
Lys Ser Gly Cys Arg Thr Pro Arg Ile Glu Leu Glu Glu Ile Gly Pro
        195                 200                 205             
Ser Leu Asn Leu Val Leu Arg Arg Thr His Leu Ala Ser Asp Asp Leu
    210                 215                 220                 
Tyr Thr Leu Ser Met Lys Met Pro Lys Ala Leu Lys Pro Lys Lys Lys
225                 230                 235                 240 
Lys Asn Ile Ser Asn Asp Thr Phe Gly Thr Thr Tyr Gly Arg Ile His
                245                 250                 255     
Met
    


<210> 8152
<211> 160
<212> PRT
<213> Homo sapiens

<400> 8152
Met Ser Asp Asn Asp Asp Ile Glu Val Glu Ser Asp Glu Glu Gln Pro
 1               5                  10                  15      
Arg Phe Gln Ser Ala Ala Asp Lys Arg Ala His His Asn Ala Leu Glu
            20                  25                  30          
Arg Lys Arg Arg Asp His Ile Lys Asp Ser Phe His Ser Leu Arg Asp
        35                  40                  45              
Ser Val Pro Ser Leu Gln Gly Glu Lys Ala Ser Arg Ala Gln Ile Leu
    50                  55                  60                  
Asp Lys Ala Thr Glu Tyr Ile Gln Tyr Met Arg Arg Lys Asn His Thr
65                  70                  75                  80  
His Gln Gln Asp Ile Asp Asp Leu Lys Arg Gln Asn Ala Leu Leu Glu
                85                  90                  95      
Gln Gln Val Arg Ala Leu Glu Lys Ala Arg Ser Ser Ala Gln Leu Gln
            100                 105                 110         
Thr Asn Tyr Pro Ser Ser Asp Asn Ser Leu Tyr Thr Asn Ala Lys Gly
        115                 120                 125             
Ser Thr Ile Ser Ala Phe Asp Gly Gly Ser Asp Ser Ser Ser Glu Ser
    130                 135                 140                 
Glu Pro Glu Glu Pro Gln Ser Arg Lys Lys Leu Arg Met Glu Ala Ser
145                 150                 155                 160 


<210> 8153
<211> 151
<212> PRT
<213> Homo sapiens

<400> 8153
Met Ser Asp Asn Asp Asp Ile Glu Val Glu Ser Asp Ala Asp Lys Arg
 1               5                  10                  15      
Ala His His Asn Ala Leu Glu Arg Lys Arg Arg Asp His Ile Lys Asp
            20                  25                  30          
Ser Phe His Ser Leu Arg Asp Ser Val Pro Ser Leu Gln Gly Glu Lys
        35                  40                  45              
Ala Ser Arg Ala Gln Ile Leu Asp Lys Ala Thr Glu Tyr Ile Gln Tyr
    50                  55                  60                  
Met Arg Arg Lys Asn His Thr His Gln Gln Asp Ile Asp Asp Leu Lys
65                  70                  75                  80  
Arg Gln Asn Ala Leu Leu Glu Gln Gln Val Arg Ala Leu Glu Lys Ala
                85                  90                  95      
Arg Ser Ser Ala Gln Leu Gln Thr Asn Tyr Pro Ser Ser Asp Asn Ser
            100                 105                 110         
Leu Tyr Thr Asn Ala Lys Gly Ser Thr Ile Ser Ala Phe Asp Gly Gly
        115                 120                 125             
Ser Asp Ser Ser Ser Glu Ser Glu Pro Glu Glu Pro Gln Ser Arg Lys
    130                 135                 140                 
Lys Leu Arg Met Glu Ala Ser
145                 150     


<210> 8154
<211> 484
<212> PRT
<213> Homo sapiens

<400> 8154
Met Phe Pro Asn Ser Ile Leu Gly His Pro Pro Phe Thr Pro Asn His
 1               5                  10                  15      
Gln Gln His Asn Asn Phe Phe Thr Leu Ser Pro Thr Val Tyr Ser His
            20                  25                  30          
Gln Gln Leu Ile Asp Ala Gln Phe Asn Phe Gln Asn Ala Asp Leu Ser
        35                  40                  45              
Arg Ala Val Ser Leu Gln Gln Leu Thr Tyr Gly Asn Val Ser Pro Ile
    50                  55                  60                  
Gln Thr Ser Ala Ser Pro Leu Phe Arg Gly Arg Lys Arg Leu Ser Asp
65                  70                  75                  80  
Glu Lys Asn Leu Pro Leu Asp Gly Lys Arg Gln Arg Phe His Ser Pro
                85                  90                  95      
His Gln Glu Pro Thr Val Val Asn Gln Ile Val Pro Leu Ser Gly Glu
            100                 105                 110         
Arg Arg Tyr Ser Met Pro Pro Leu Phe His Thr His Tyr Val Pro Asp
        115                 120                 125             
Ile Val Arg Cys Val Pro Pro Phe Arg Glu Ile Ala Phe Leu Glu Pro
    130                 135                 140                 
Arg Glu Ile Thr Leu Pro Glu Ala Lys Asp Lys Leu Ser Gln Gln Ile
145                 150                 155                 160 
Leu Glu Leu Phe Glu Thr Cys Gln Gln Gln Ile Ser Asp Leu Lys Lys
                165                 170                 175     
Lys Glu Leu Cys Arg Thr Gln Leu Gln Arg Glu Ile Gln Leu Leu Phe
            180                 185                 190         
Pro Gln Ser Arg Leu Phe Leu Val Gly Ser Ser Leu Asn Gly Phe Gly
        195                 200                 205             
Thr Arg Ser Ser Asp Gly Asp Leu Cys Leu Val Val Lys Glu Glu Pro
    210                 215                 220                 
Cys Phe Phe Gln Val Asn Gln Lys Thr Glu Ala Arg His Ile Leu Thr
225                 230                 235                 240 
Leu Val His Lys His Phe Cys Thr Arg Leu Ser Gly Tyr Ile Glu Arg
                245                 250                 255     
Pro Gln Leu Ile Arg Ala Lys Val Pro Ile Val Lys Phe Arg Asp Lys
            260                 265                 270         
Val Ser Cys Val Glu Phe Asp Leu Asn Val Asn Asn Ile Val Gly Ile
        275                 280                 285             
Arg Asn Thr Phe Leu Leu Arg Thr Tyr Ala Tyr Leu Glu Asn Arg Val
    290                 295                 300                 
Arg Pro Leu Val Leu Val Ile Lys Lys Trp Ala Ser His His Gln Ile
305                 310                 315                 320 
Asn Asp Ala Ser Arg Gly Thr Leu Ser Ser Tyr Ser Leu Val Leu Met
                325                 330                 335     
Val Leu His Tyr Leu Gln Thr Leu Pro Glu Pro Ile Leu Pro Ser Leu
            340                 345                 350         
Gln Lys Ile Tyr Pro Glu Ser Phe Ser Pro Ala Ile Gln Leu His Leu
        355                 360                 365             
Val His Gln Ala Pro Cys Asn Val Pro Pro Tyr Leu Ser Lys Asn Glu
    370                 375                 380                 
Ser Asn Leu Gly Asp Leu Leu Leu Gly Phe Leu Lys Tyr Tyr Ala Thr
385                 390                 395                 400 
Glu Phe Asp Trp Asn Ser Gln Met Ile Ser Val Arg Glu Ala Lys Ala
                405                 410                 415     
Ile Pro Arg Pro Asp Gly Ile Glu Trp Arg Asn Lys Tyr Ile Cys Val
            420                 425                 430         
Glu Glu Pro Phe Asp Gly Thr Asn Thr Ala Arg Ala Val His Glu Lys
        435                 440                 445             
Gln Lys Phe Asp Met Ile Lys Asp Gln Phe Leu Lys Ser Trp His Arg
    450                 455                 460                 
Leu Lys Asn Lys Arg Asp Leu Asn Ser Ile Leu Pro Val Arg Ala Ala
465                 470                 475                 480 
Val Leu Lys Arg
                


<210> 8155
<211> 546
<212> PRT
<213> Homo sapiens

<400> 8155
Met Ala Asn Asn Ser Pro Ala Leu Thr Gly Asn Ser Gln Pro Gln His
 1               5                  10                  15      
Gln Ala Ala Ala Ala Ala Ala Gln Gln Gln Gln Gln Cys Gly Gly Gly
            20                  25                  30          
Gly Ala Thr Lys Pro Ala Val Ser Gly Lys Gln Gly Asn Val Leu Pro
        35                  40                  45              
Leu Trp Gly Ser Glu Lys Thr Met Asn Leu Asn Pro Met Ile Leu Thr
    50                  55                  60                  
Asn Ile Leu Ser Ser Pro Tyr Phe Lys Val Gln Leu Tyr Glu Leu Lys
65                  70                  75                  80  
Thr Tyr His Glu Val Val Asp Glu Ile Tyr Phe Lys Val Thr His Val
                85                  90                  95      
Glu Pro Trp Glu Lys Gly Ser Arg Lys Thr Ala Gly Gln Thr Gly Met
            100                 105                 110         
Cys Gly Gly Val Arg Gly Val Gly Thr Gly Gly Ile Val Ser Thr Ala
        115                 120                 125             
Phe Cys Leu Leu Tyr Lys Leu Phe Thr Leu Lys Leu Thr Arg Lys Gln
    130                 135                 140                 
Val Met Gly Leu Ile Thr His Thr Asp Ser Pro Tyr Ile Arg Ala Leu
145                 150                 155                 160 
Gly Phe Met Tyr Ile Arg Tyr Thr Gln Pro Pro Thr Asp Leu Trp Asp
                165                 170                 175     
Trp Phe Glu Ser Phe Leu Asp Asp Glu Glu Asp Leu Asp Val Lys Ala
            180                 185                 190         
Gly Gly Gly Cys Val Met Thr Ile Gly Glu Met Leu Arg Ser Phe Leu
        195                 200                 205             
Thr Lys Leu Glu Trp Phe Ser Thr Leu Phe Pro Arg Ile Pro Val Pro
    210                 215                 220                 
Val Gln Lys Asn Ile Asp Gln Gln Ile Lys Thr Arg Pro Arg Lys Ile
225                 230                 235                 240 
Lys Lys Asp Gly Lys Glu Gly Ala Glu Glu Ile Asp Arg His Val Glu
                245                 250                 255     
Arg Arg Arg Ser Arg Ser Pro Arg Arg Ser Leu Ser Pro Arg Arg Ser
            260                 265                 270         
Pro Arg Arg Ser Arg Ser Arg Ser His His Arg Glu Gly His Gly Ser
        275                 280                 285             
Ser Ser Phe Asp Arg Glu Leu Glu Arg Glu Lys Glu Arg Gln Arg Leu
    290                 295                 300                 
Glu Arg Glu Ala Lys Glu Arg Glu Lys Glu Arg Arg Arg Ser Arg Ser
305                 310                 315                 320 
Ile Asp Arg Gly Leu Glu Arg Arg Arg Ser Arg Ser Arg Glu Arg His
                325                 330                 335     
Arg Ser Arg Ser Arg Ser Arg Asp Arg Lys Gly Asp Arg Arg Asp Arg
            340                 345                 350         
Asp Arg Glu Arg Glu Lys Glu Asn Glu Arg Gly Arg Arg Arg Asp Arg
        355                 360                 365             
Asp Tyr Asp Lys Glu Arg Gly Asn Glu Arg Glu Lys Glu Arg Glu Arg
    370                 375                 380                 
Ser Arg Glu Arg Ser Lys Glu Gln Arg Ser Arg Gly Glu Val Glu Glu
385                 390                 395                 400 
Lys Lys His Lys Glu Asp Lys Asp Asp Arg Arg His Arg Asp Asp Lys
                405                 410                 415     
Arg Asp Ser Lys Lys Glu Lys Lys His Ser Arg Ser Arg Ser Arg Glu
            420                 425                 430         
Arg Lys His Arg Ser Arg Ser Arg Ser Arg Asn Ala Gly Lys Arg Ser
        435                 440                 445             
Arg Ser Arg Ser Lys Glu Lys Ser Ser Lys His Lys Asn Glu Ser Lys
    450                 455                 460                 
Glu Lys Ser Asn Lys Arg Ser Arg Ser Gly Ser Gln Gly Arg Thr Asp
465                 470                 475                 480 
Ser Val Glu Lys Ser Lys Lys Arg Glu His Ser Pro Ser Lys Glu Lys
                485                 490                 495     
Ser Arg Lys Arg Ser Arg Ser Lys Glu Arg Ser His Lys Arg Asp His
            500                 505                 510         
Ser Asp Ser Lys Asp Gln Ser Asp Lys His Asp Arg Arg Arg Ser Gln
        515                 520                 525             
Ser Ile Glu Gln Glu Ser Gln Glu Lys Gln His Lys Asn Lys Asp Glu
    530                 535                 540                 
Thr Val
545     


<210> 8156
<211> 860
<212> PRT
<213> Homo sapiens

<400> 8156
Met Leu Gly Lys Leu Asp Pro Phe Tyr Gln Pro Ser Val Ser Lys Gln
 1               5                  10                  15      
Lys Thr Ser Ala Glu Ile Ile Ser Glu Ala Arg Asn Ala Leu Arg Thr
            20                  25                  30          
Val Arg Thr Gln Arg Pro Phe Thr Pro Gln Glu Ala Gln Arg Lys Leu
        35                  40                  45              
Phe Gly Pro Ala Ser Ser Arg Thr Ser Glu Asn Arg Pro Pro Ser Ser
    50                  55                  60                  
Phe Ser Leu His Ala Ser Ser Phe Glu Ser Ser Asp Ser Arg Pro Ile
65                  70                  75                  80  
Ser Gly Thr Arg Leu Ser Pro Leu Glu Leu Lys Pro Lys Val Pro Ala
                85                  90                  95      
Ser Pro Thr Arg Glu Glu Asp Ser Cys Phe Ser Phe Pro Lys Pro Pro
            100                 105                 110         
Val Asp Pro Ala Lys Ile Arg Arg Val Ser Asn Ala Arg Ala Arg Leu
        115                 120                 125             
Phe Arg Ala Ala Ser Gln Arg Ala Leu Leu Pro Asp Arg Ser Leu Pro
    130                 135                 140                 
Pro Ser Asp Ser Lys Lys Thr Val Glu Ser Lys Glu Thr Val Met Met
145                 150                 155                 160 
Gly Asp Ser Met Val Lys Ile Asn Gly Ile Tyr Leu Thr Lys Ser Asn
                165                 170                 175     
Ala Ile Cys His Leu Lys Ser His Pro Leu Gln Leu Thr Asp Asp Gly
            180                 185                 190         
Gly Phe Ser Glu Ile Lys Glu Gln Glu Met Phe Lys Gly Thr Thr Ser
        195                 200                 205             
Leu Pro Ser His Leu Lys Asn Gly Gly Asp Gln Gly Lys Arg His Ala
    210                 215                 220                 
Arg Ala Ser Ser Cys Pro Ser Ser Ser Asp Leu Ser Arg Leu Gln Thr
225                 230                 235                 240 
Lys Ala Val Pro Lys Ala Asp Leu Gln Glu Glu Asp Ala Glu Ile Glu
                245                 250                 255     
Val Asp Glu Val Phe Trp Asn Thr Arg Ile Val Pro Ile Leu Arg Glu
            260                 265                 270         
Leu Glu Lys Glu Glu Asn Ile Glu Thr Val Cys Ala Ala Cys Thr Gln
        275                 280                 285             
Leu His His Ala Leu Glu Glu Gly Asn Met Leu Gly Asn Lys Phe Lys
    290                 295                 300                 
Gly Arg Ser Ile Leu Leu Lys Thr Leu Cys Lys Leu Val Asp Val Gly
305                 310                 315                 320 
Ser Asp Ser Leu Ser Leu Lys Leu Ala Lys Ile Ile Leu Ala Leu Lys
                325                 330                 335     
Val Ser Arg Lys Asn Leu Leu Asn Val Cys Lys Leu Ile Phe Lys Ile
            340                 345                 350         
Ser Arg Asn Glu Lys Asn Asp Ser Leu Ile Gln Asn Asp Ser Ile Leu
        355                 360                 365             
Glu Ser Leu Leu Glu Val Leu Arg Ser Glu Asp Leu Gln Thr Asn Met
    370                 375                 380                 
Glu Ala Phe Leu Tyr Cys Met Gly Ser Ile Lys Phe Ile Ser Gly Asn
385                 390                 395                 400 
Leu Gly Phe Leu Asn Glu Met Ile Ser Lys Gly Ala Val Glu Ile Leu
                405                 410                 415     
Ile Asn Leu Ile Lys Gln Ile Asn Glu Asp Ile Lys Lys Cys Gly Thr
            420                 425                 430         
Phe Leu Pro Asn Ser Gly His Leu Leu Val Gln Val Thr Ala Thr Leu
        435                 440                 445             
Arg Asn Leu Val Asp Ser Ser Leu Val Arg Ser Lys Phe Leu Asn Ile
    450                 455                 460                 
Ser Ala Leu Pro Gln Leu Cys Thr Ala Met Glu Gln Tyr Lys Gly Asp
465                 470                 475                 480 
Lys Asp Val Cys Thr Asn Ile Ala Arg Ile Phe Ser Lys Leu Thr Ser
                485                 490                 495     
Tyr Arg Asp Cys Cys Thr Ala Leu Ala Ser Tyr Ser Arg Cys Tyr Ala
            500                 505                 510         
Leu Phe Leu Asn Leu Ile Asn Lys Tyr Gln Lys Lys Gln Asp Leu Val
        515                 520                 525             
Val Arg Val Val Phe Ile Leu Gly Asn Leu Thr Ala Lys Asn Asn Gln
    530                 535                 540                 
Ala Arg Glu Gln Phe Ser Lys Glu Lys Gly Ser Ile Gln Thr Leu Leu
545                 550                 555                 560 
Ser Leu Phe Gln Thr Phe His Gln Leu Asp Leu His Ser Gln Lys Pro
                565                 570                 575     
Val Gly Gln Arg Gly Glu Gln His Arg Ala Gln Arg Pro Pro Ser Glu
            580                 585                 590         
Ala Glu Asp Val Leu Ile Lys Leu Thr Arg Val Leu Ala Asn Ile Ala
        595                 600                 605             
Ile His Pro Gly Val Gly Pro Val Leu Ala Ala Asn Pro Gly Ile Val
    610                 615                 620                 
Gly Leu Leu Leu Thr Thr Leu Glu Tyr Lys Ser Leu Asp Asp Cys Glu
625                 630                 635                 640 
Glu Leu Val Ile Asn Ala Thr Ala Thr Ile Asn Asn Leu Ser Tyr Tyr
                645                 650                 655     
Gln Val Lys Asn Ser Ile Ile Gln Asp Lys Lys Leu Tyr Ile Ala Glu
            660                 665                 670         
Leu Leu Leu Lys Leu Leu Val Ser Asn Asn Met Asp Gly Ile Leu Glu
        675                 680                 685             
Ala Val Arg Val Phe Gly Asn Leu Ser Gln Asp His Asp Val Cys Asp
    690                 695                 700                 
Phe Ile Val Gln Asn Asn Val His Arg Phe Met Met Ala Leu Leu Asp
705                 710                 715                 720 
Ala Gln His Gln Asp Ile Cys Phe Ser Ala Cys Gly Val Leu Leu Asn
                725                 730                 735     
Leu Thr Val Asp Lys Asp Lys Arg Val Ile Leu Lys Glu Gly Gly Gly
            740                 745                 750         
Ile Lys Lys Leu Val Asp Cys Leu Arg Asp Leu Gly Pro Thr Asp Trp
        755                 760                 765             
Gln Leu Ala Cys Leu Val Cys Lys Thr Leu Trp Asn Phe Ser Glu Asn
    770                 775                 780                 
Ile Thr Asn Ala Ser Ser Cys Phe Gly Asn Glu Asp Thr Asn Thr Leu
785                 790                 795                 800 
Leu Leu Leu Leu Ser Ser Phe Leu Asp Glu Glu Leu Ala Leu Asp Gly
                805                 810                 815     
Ser Phe Asp Pro Asp Leu Lys Asn Tyr His Lys Leu His Trp Glu Thr
            820                 825                 830         
Glu Phe Lys Pro Val Ala Gln Gln Leu Leu Asn Arg Ile Gln Arg His
        835                 840                 845             
His Thr Phe Leu Glu Pro Leu Pro Ile Pro Ser Phe
    850                 855                 860 


<210> 8157
<211> 794
<212> PRT
<213> Homo sapiens

<400> 8157
Leu Leu Glu Ser Gly Arg Ala Gly Gly Arg Gly Gly Arg Ser Gly Ala
 1               5                  10                  15      
Ala Ala Ala Glu Val Pro Glu Ser Pro Leu Gly Ala Ala Leu Arg Arg
            20                  25                  30          
Arg Asp Pro Gly Leu Trp Pro Arg Arg Leu Arg Pro Pro Gly Gly Pro
        35                  40                  45              
Gly Pro Pro Gly His Gly Ala Ser Arg Thr Pro Ser Pro Pro Pro Leu
    50                  55                  60                  
Ser Ser Pro Ala Ala Pro Gly Leu Gly Arg Pro Ser Gly Lys Met Phe
65                  70                  75                  80  
Ser Ala Leu Lys Lys Leu Val Gly Ser Asp Gln Ala Pro Gly Arg Asp
                85                  90                  95      
Lys Asn Ile Pro Ala Gly Leu Gln Ser Met Asn Gln Ala Leu Gln Arg
            100                 105                 110         
Arg Phe Ala Lys Gly Val Gln Tyr Asn Met Lys Ile Val Ile Arg Gly
        115                 120                 125             
Asp Arg Asn Thr Gly Lys Thr Ala Leu Trp His Arg Leu Gln Gly Arg
    130                 135                 140                 
Pro Phe Val Glu Glu Tyr Ile Pro Thr Gln Glu Ile Gln Val Thr Ser
145                 150                 155                 160 
Ile His Trp Ser Tyr Lys Thr Thr Asp Asp Ile Val Lys Val Glu Val
                165                 170                 175     
Trp Asp Val Val Asp Lys Gly Lys Cys Lys Lys Arg Gly Asp Gly Leu
            180                 185                 190         
Lys Met Glu Asn Asp Pro Gln Glu Ala Glu Ser Glu Met Ala Leu Asp
        195                 200                 205             
Ala Glu Phe Leu Asp Val Tyr Lys Asn Cys Asn Gly Val Val Met Met
    210                 215                 220                 
Phe Asp Ile Thr Lys Gln Trp Thr Phe Asn Tyr Ile Leu Arg Glu Leu
225                 230                 235                 240 
Pro Lys Val Pro Thr His Val Pro Val Cys Val Leu Gly Asn Tyr Arg
                245                 250                 255     
Asp Met Gly Glu His Arg Val Ile Leu Pro Asp Asp Val Arg Asp Phe
            260                 265                 270         
Ile Asp Asn Leu Asp Ser Arg Pro Pro Gly Ser Ser Tyr Phe Arg Tyr
        275                 280                 285             
Ala Glu Ser Ser Met Lys Asn Ser Phe Gly Leu Lys Tyr Leu His Lys
    290                 295                 300                 
Phe Phe Asn Ile Pro Phe Leu Gln Leu Gln Arg Glu Thr Leu Leu Arg
305                 310                 315                 320 
Gln Leu Glu Thr Asn Gln Leu Asp Met Asp Ala Thr Leu Glu Glu Leu
                325                 330                 335     
Ser Val Gln Gln Glu Thr Glu Asp Gln Asn Tyr Gly Ile Phe Leu Glu
            340                 345                 350         
Met Met Glu Ala Arg Ser Arg Gly His Ala Ser Pro Leu Ala Ala Asn
        355                 360                 365             
Gly Gln Ser Pro Ser Pro Gly Ser Gln Ser Pro Val Val Pro Ala Gly
    370                 375                 380                 
Ala Val Ser Thr Gly Ser Ser Ser Pro Gly Thr Pro Gln Pro Ala Pro
385                 390                 395                 400 
Gln Leu Pro Leu Asn Ala Ala Pro Pro Ser Ser Val Pro Pro Val Pro
                405                 410                 415     
Pro Ser Glu Ala Leu Pro Pro Pro Ala Cys Pro Ser Ala Pro Ala Pro
            420                 425                 430         
Arg Arg Ser Ile Ile Ser Arg Leu Phe Gly Thr Ser Pro Ala Thr Glu
        435                 440                 445             
Ala Ala Pro Pro Pro Pro Glu Pro Val Pro Ala Ala Glu Gly Pro Ala
    450                 455                 460                 
Thr Val Gln Ser Val Glu Asp Phe Val Pro Asp Asp Arg Leu Asp Arg
465                 470                 475                 480 
Ser Phe Leu Glu Asp Thr Thr Pro Ala Arg Asp Glu Lys Lys Val Gly
                485                 490                 495     
Ala Lys Ala Ala Gln Gln Asp Ser Asp Ser Asp Gly Glu Ala Leu Gly
            500                 505                 510         
Gly Asn Pro Met Val Ala Gly Phe Gln Asp Asp Val Asp Leu Glu Asp
        515                 520                 525             
Gln Pro Arg Gly Ser Pro Pro Leu Pro Ala Gly Pro Val Pro Ser Gln
    530                 535                 540                 
Asp Ile Thr Leu Ser Ser Glu Glu Glu Ala Glu Val Ala Ala Pro Thr
545                 550                 555                 560 
Lys Gly Pro Ala Pro Ala Pro Gln Gln Cys Ser Glu Pro Glu Thr Lys
                565                 570                 575     
Trp Ser Ser Ile Pro Ala Ser Lys Pro Arg Arg Gly Thr Ala Pro Thr
            580                 585                 590         
Arg Thr Ala Ala Pro Pro Trp Pro Gly Gly Val Ser Val Arg Thr Gly
        595                 600                 605             
Pro Glu Lys Arg Ser Ser Thr Arg Pro Pro Ala Glu Met Glu Pro Gly
    610                 615                 620                 
Lys Gly Glu Gln Ala Ser Ser Ser Glu Ser Asp Pro Glu Gly Pro Ile
625                 630                 635                 640 
Ala Ala Gln Met Leu Ser Phe Val Met Asp Asp Pro Asp Phe Glu Ser
                645                 650                 655     
Glu Gly Ser Asp Thr Gln Arg Arg Ala Asp Asp Phe Pro Val Arg Asp
            660                 665                 670         
Asp Pro Ser Asp Val Thr Asp Glu Asp Glu Gly Pro Ala Glu Pro Pro
        675                 680                 685             
Pro Pro Pro Lys Leu Pro Leu Pro Ala Phe Arg Leu Lys Asn Asp Ser
    690                 695                 700                 
Asp Leu Phe Gly Leu Gly Leu Glu Glu Ala Gly Pro Lys Glu Ser Ser
705                 710                 715                 720 
Glu Glu Gly Lys Glu Gly Lys Thr Pro Ser Lys Glu Lys Lys Lys Lys
                725                 730                 735     
Lys Lys Lys Gly Lys Glu Glu Glu Glu Lys Ala Ala Lys Lys Lys Ser
            740                 745                 750         
Lys His Lys Lys Ser Lys Asp Lys Glu Glu Gly Lys Glu Glu Arg Arg
        755                 760                 765             
Arg Arg Gln Gln Arg Pro Pro Arg Ser Arg Glu Arg Thr Ala Ala Asp
    770                 775                 780                 
Glu Leu Glu Ala Phe Leu Gly Gly Gly Ala
785                 790                 


<210> 8158
<211> 476
<212> PRT
<213> Homo sapiens

<400> 8158
Met Ser Asp Phe Asp Glu Phe Glu Arg Gln Leu Asn Glu Asn Lys Gln
 1               5                  10                  15      
Glu Arg Asp Lys Glu Asn Arg His Arg Lys Arg Ser His Ser Arg Ser
            20                  25                  30          
Arg Ser Arg Asp Arg Lys Arg Arg Ser Arg Ser Arg Asp Arg Arg Asn
        35                  40                  45              
Arg Asp Gln Arg Ser Ala Ser Arg Asp Arg Arg Arg Arg Ser Lys Pro
    50                  55                  60                  
Leu Thr Arg Gly Ala Lys Glu Glu His Gly Gly Leu Ile Arg Ser Pro
65                  70                  75                  80  
Arg His Glu Lys Lys Lys Lys Val Arg Lys Tyr Trp Asp Val Pro Pro
                85                  90                  95      
Pro Gly Phe Glu His Ile Thr Pro Met Gln Tyr Lys Ala Met Gln Ala
            100                 105                 110         
Ala Gly Gln Ile Pro Ala Thr Ala Leu Leu Pro Thr Met Thr Pro Asp
        115                 120                 125             
Gly Leu Ala Val Thr Pro Thr Pro Val Pro Val Val Gly Ser Gln Met
    130                 135                 140                 
Thr Arg Gln Ala Arg Arg Leu Tyr Val Gly Asn Ile Pro Phe Gly Ile
145                 150                 155                 160 
Thr Glu Glu Ala Met Met Asp Phe Phe Asn Ala Gln Met Arg Leu Gly
                165                 170                 175     
Gly Leu Thr Gln Ala Pro Gly Asn Pro Val Leu Ala Val Gln Ile Asn
            180                 185                 190         
Gln Asp Lys Asn Phe Ala Phe Leu Glu Phe Arg Ser Val Asp Glu Thr
        195                 200                 205             
Thr Gln Ala Met Ala Phe Asp Gly Ile Ile Phe Gln Gly Gln Ser Leu
    210                 215                 220                 
Lys Ile Arg Arg Pro His Asp Tyr Gln Pro Leu Pro Gly Met Ser Glu
225                 230                 235                 240 
Asn Pro Ser Val Tyr Val Pro Gly Val Val Ser Thr Val Val Pro Asp
                245                 250                 255     
Ser Ala His Lys Leu Phe Ile Gly Gly Leu Pro Asn Tyr Leu Asn Asp
            260                 265                 270         
Asp Gln Val Lys Glu Leu Leu Thr Ser Phe Gly Pro Leu Lys Ala Phe
        275                 280                 285             
Asn Leu Val Lys Asp Ser Ala Thr Gly Leu Ser Lys Gly Tyr Ala Phe
    290                 295                 300                 
Cys Glu Tyr Val Asp Ile Asn Val Thr Asp Gln Ala Ile Ala Gly Leu
305                 310                 315                 320 
Asn Gly Met Gln Leu Gly Asp Lys Lys Leu Leu Val Gln Arg Ala Ser
                325                 330                 335     
Val Gly Ala Lys Asn Ala Thr Leu Val Ser Pro Pro Ala Gln Thr Ile
            340                 345                 350         
Asn Gln Thr Pro Val Thr Leu Gln Val Pro Gly Leu Met Ser Ser Gln
        355                 360                 365             
Val Gln Met Gly Gly His Pro Thr Glu Val Leu Cys Leu Met Asn Met
    370                 375                 380                 
Val Leu Pro Glu Glu Leu Leu Asp Asp Glu Glu Tyr Glu Glu Ile Val
385                 390                 395                 400 
Glu Asp Val Arg Asp Glu Cys Ser Lys Tyr Gly Leu Val Lys Ser Ile
                405                 410                 415     
Glu Ile Pro Arg Pro Val Asp Gly Val Glu Val Pro Gly Cys Gly Lys
            420                 425                 430         
Ile Phe Val Glu Phe Thr Ser Val Phe Asp Cys Gln Lys Ala Met Gln
        435                 440                 445             
Gly Leu Thr Gly Arg Lys Phe Ala Asn Arg Val Val Val Thr Lys Tyr
    450                 455                 460                 
Cys Asp Pro Asp Ser Tyr His Arg Arg Asp Phe Trp
465                 470                 475     


<210> 8159
<211> 948
<212> PRT
<213> Homo sapiens

<400> 8159
Met Ile Leu Val Leu Val Lys Ala Leu Ser Asp Val Cys Ala Gly Thr
 1               5                  10                  15      
Ser Gly Phe Leu Leu Asp Phe Ser Ser Gln Thr Ser Pro Gly Thr Asp
            20                  25                  30          
Asn Gly Glu Ala Leu Pro Glu Ser Ile Pro Ser Ala Pro Gly Thr Leu
        35                  40                  45              
Pro His Phe Ile Glu Glu Pro Asp Asp Ala Tyr Ile Ile Lys Ser Asn
    50                  55                  60                  
Pro Ile Ala Leu Arg Cys Lys Ala Arg Pro Ala Met Gln Ile Phe Phe
65                  70                  75                  80  
Lys Cys Asn Gly Glu Trp Val His Gln Asn Glu His Val Ser Glu Glu
                85                  90                  95      
Thr Leu Asp Glu Ser Ser Gly Leu Lys Val Arg Glu Val Phe Ile Asn
            100                 105                 110         
Val Thr Arg Gln Gln Val Glu Asp Phe His Gly Pro Glu Asp Tyr Trp
        115                 120                 125             
Cys Gln Cys Val Ala Trp Ser His Leu Gly Thr Ser Lys Ser Arg Lys
    130                 135                 140                 
Ala Ser Val Arg Ile Ala Tyr Leu Arg Lys Asn Phe Glu Gln Asp Pro
145                 150                 155                 160 
Gln Gly Arg Glu Val Pro Ile Glu Gly Met Ile Val Leu His Cys Arg
                165                 170                 175     
Pro Pro Glu Gly Val Pro Ala Ala Glu Val Glu Trp Leu Lys Asn Glu
            180                 185                 190         
Glu Pro Ile Asp Ser Glu Gln Asp Glu Asn Ile Asp Thr Arg Ala Asp
        195                 200                 205             
His Asn Leu Ile Ile Arg Gln Ala Arg Leu Ser Asp Ser Gly Asn Tyr
    210                 215                 220                 
Thr Cys Met Ala Ala Asn Ile Val Ala Lys Arg Arg Ser Leu Ser Ala
225                 230                 235                 240 
Thr Val Val Val Tyr Val Asn Gly Gly Trp Ser Ser Trp Thr Glu Trp
                245                 250                 255     
Ser Ala Cys Asn Val Arg Cys Gly Arg Gly Trp Gln Lys Arg Ser Arg
            260                 265                 270         
Thr Cys Thr Asn Pro Ala Pro Leu Asn Gly Gly Ala Phe Cys Glu Gly
        275                 280                 285             
Met Ser Val Gln Lys Ile Thr Cys Thr Ser Leu Cys Pro Val Asp Gly
    290                 295                 300                 
Ser Trp Glu Val Trp Ser Glu Trp Ser Val Cys Ser Pro Glu Cys Glu
305                 310                 315                 320 
His Leu Arg Ile Arg Glu Cys Thr Ala Pro Pro Pro Arg Asn Gly Gly
                325                 330                 335     
Lys Phe Cys Glu Gly Leu Ser Gln Glu Ser Glu Asn Cys Thr Asp Gly
            340                 345                 350         
Leu Cys Ile Leu Asp Lys Lys Pro Leu His Glu Ile Lys Pro Gln Ser
        355                 360                 365             
Ile Glu Asn Ala Ser Asp Ile Ala Leu Tyr Ser Gly Leu Gly Ala Ala
    370                 375                 380                 
Val Val Ala Val Ala Val Leu Val Ile Gly Val Thr Leu Tyr Arg Arg
385                 390                 395                 400 
Ser Gln Ser Asp Tyr Gly Val Asp Val Ile Asp Ser Ser Ala Leu Thr
                405                 410                 415     
Gly Gly Phe Gln Thr Phe Asn Phe Lys Thr Val Arg Gln Gly Asn Ser
            420                 425                 430         
Leu Leu Leu Asn Ser Ala Met Gln Pro Asp Leu Thr Val Ser Arg Thr
        435                 440                 445             
Tyr Ser Gly Pro Ile Cys Leu Gln Asp Pro Leu Asp Lys Glu Leu Met
    450                 455                 460                 
Thr Glu Ser Ser Leu Phe Asn Pro Leu Ser Asp Ile Lys Val Lys Val
465                 470                 475                 480 
Gln Ser Ser Phe Met Val Ser Leu Gly Val Ser Glu Arg Ala Glu Tyr
                485                 490                 495     
His Gly Lys Asn His Ser Arg Thr Phe Pro His Gly Asn Asn His Ser
            500                 505                 510         
Phe Ser Thr Met His Pro Arg Asn Lys Met Pro Tyr Ile Gln Asn Leu
        515                 520                 525             
Ser Ser Leu Pro Thr Arg Thr Glu Leu Arg Thr Thr Gly Val Phe Gly
    530                 535                 540                 
His Leu Gly Gly Arg Leu Val Met Pro Asn Thr Gly Val Ser Leu Leu
545                 550                 555                 560 
Ile Pro His Gly Ala Ile Pro Glu Glu Asn Ser Trp Glu Ile Tyr Met
                565                 570                 575     
Ser Ile Asn Gln Gly Glu Pro Ser Leu Gln Ser Asp Gly Ser Glu Val
            580                 585                 590         
Leu Leu Ser Pro Glu Val Thr Cys Gly Pro Pro Asp Met Ile Val Thr
        595                 600                 605             
Thr Pro Phe Ala Leu Thr Ile Pro His Cys Ala Asp Val Ser Ser Glu
    610                 615                 620                 
His Trp Asn Ile His Leu Lys Lys Arg Thr Gln Gln Gly Lys Trp Glu
625                 630                 635                 640 
Glu Val Met Ser Val Glu Asp Glu Ser Thr Ser Cys Tyr Cys Leu Leu
                645                 650                 655     
Asp Pro Phe Ala Cys His Val Leu Leu Asp Ser Phe Gly Thr Tyr Ala
            660                 665                 670         
Leu Thr Gly Glu Pro Ile Thr Asp Cys Ala Val Lys Gln Leu Lys Val
        675                 680                 685             
Ala Val Phe Gly Cys Met Ser Cys Asn Ser Leu Asp Tyr Asn Leu Arg
    690                 695                 700                 
Val Tyr Cys Val Asp Asn Thr Pro Cys Ala Phe Gln Glu Val Val Ser
705                 710                 715                 720 
Asp Glu Arg His Gln Gly Gly Gln Leu Leu Glu Glu Pro Lys Leu Leu
                725                 730                 735     
His Phe Lys Gly Asn Thr Phe Ser Leu Gln Ile Ser Val Leu Asp Ile
            740                 745                 750         
Pro Pro Phe Leu Trp Arg Ile Lys Pro Phe Thr Ala Cys Gln Glu Val
        755                 760                 765             
Pro Phe Ser Arg Val Trp Cys Ser Asn Arg Gln Pro Leu His Cys Ala
    770                 775                 780                 
Phe Ser Leu Glu Arg Tyr Thr Pro Thr Thr Thr Gln Leu Ser Cys Lys
785                 790                 795                 800 
Ile Cys Ile Arg Gln Leu Lys Gly His Glu Gln Ile Leu Gln Val Gln
                805                 810                 815     
Thr Ser Ile Leu Glu Ser Glu Arg Glu Thr Ile Thr Phe Phe Ala Gln
            820                 825                 830         
Glu Asp Ser Thr Phe Pro Ala Gln Thr Gly Pro Lys Ala Phe Lys Ile
        835                 840                 845             
Pro Tyr Ser Ile Arg Gln Arg Ile Cys Ala Thr Phe Asp Thr Pro Asn
    850                 855                 860                 
Ala Lys Gly Lys Asp Trp Gln Met Leu Ala Gln Lys Asn Ser Ile Asn
865                 870                 875                 880 
Arg Asn Leu Ser Tyr Phe Ala Thr Gln Ser Ser Pro Ser Ala Val Ile
                885                 890                 895     
Leu Asn Leu Trp Glu Ala Arg His Gln His Asp Gly Asp Leu Asp Ser
            900                 905                 910         
Leu Ala Cys Ala Leu Glu Glu Ile Gly Arg Thr His Thr Lys Leu Ser
        915                 920                 925             
Asn Ile Ser Glu Ser Gln Leu Asp Glu Ala Asp Phe Asn Tyr Ser Arg
    930                 935                 940                 
Gln Asn Gly Leu
945             


<210> 8160
<211> 925
<212> PRT
<213> Homo sapiens

<400> 8160
Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile
 1               5                  10                  15      
Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp
            20                  25                  30          
Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys
        35                  40                  45              
Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu
    50                  55                  60                  
Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala
65                  70                  75                  80  
Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys
                85                  90                  95      
Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro
            100                 105                 110         
Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser
        115                 120                 125             
Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser
    130                 135                 140                 
Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu
145                 150                 155                 160 
Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu
                165                 170                 175     
Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile
            180                 185                 190         
Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp
        195                 200                 205             
Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu
    210                 215                 220                 
Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro
225                 230                 235                 240 
Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys
                245                 250                 255     
Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe
            260                 265                 270         
Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly
        275                 280                 285             
Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu
    290                 295                 300                 
Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg
305                 310                 315                 320 
Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln
                325                 330                 335     
Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val
            340                 345                 350         
Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu
        355                 360                 365             
Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn
    370                 375                 380                 
Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly
385                 390                 395                 400 
Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp
                405                 410                 415     
Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala
            420                 425                 430         
Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu
        435                 440                 445             
Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu
    450                 455                 460                 
Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg
465                 470                 475                 480 
Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu
                485                 490                 495     
Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp
            500                 505                 510         
Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys
        515                 520                 525             
Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His
    530                 535                 540                 
Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met
545                 550                 555                 560 
Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala
                565                 570                 575     
Ala Gly Phe Glu Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu
            580                 585                 590         
Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn
        595                 600                 605             
Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu
    610                 615                 620                 
Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val
625                 630                 635                 640 
Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu
                645                 650                 655     
Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly
            660                 665                 670         
Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser
        675                 680                 685             
Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile
    690                 695                 700                 
Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn
705                 710                 715                 720 
Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser
                725                 730                 735     
Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln
            740                 745                 750         
Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu
        755                 760                 765             
Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln
    770                 775                 780                 
Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val
785                 790                 795                 800 
Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu
                805                 810                 815     
Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr
            820                 825                 830         
Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro
        835                 840                 845             
Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys
    850                 855                 860                 
Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys
865                 870                 875                 880 
Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp
                885                 890                 895     
Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His
            900                 905                 910         
Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys
        915                 920                 925 


<210> 8161
<211> 854
<212> PRT
<213> Homo sapiens

<400> 8161
Met Asp Phe Ser Met Val Ala Gly Ala Ala Ala Tyr Asn Glu Lys Ser
 1               5                  10                  15      
Gly Arg Ile Thr Ser Leu Ser Leu Leu Phe Gln Lys Val Phe Ala Gln
            20                  25                  30          
Ile Phe Pro Gln Trp Arg Lys Gly Asn Thr Glu Glu Cys Leu Pro Tyr
        35                  40                  45              
Lys Cys Ser Glu Thr Gly Ala Leu Gly Glu Asn Tyr Ser Trp Gln Ile
    50                  55                  60                  
Pro Ile Asn His Asn Asp Phe Lys Ile Leu Lys Asn Asn Glu Arg Gln
65                  70                  75                  80  
Leu Cys Glu Val Leu Gln Asn Lys Phe Gly Cys Ile Ser Thr Leu Val
                85                  90                  95      
Ser Pro Val Gln Glu Gly Asn Ser Lys Ser Leu Gln Val Phe Arg Lys
            100                 105                 110         
Met Leu Thr Pro Arg Ile Glu Leu Ser Val Trp Lys Asp Asp Leu Thr
        115                 120                 125             
Thr His Ala Val Asp Ala Val Val Asn Ala Ala Asn Glu Asp Leu Leu
    130                 135                 140                 
His Gly Gly Gly Leu Ala Leu Ala Leu Val Lys Ala Gly Gly Phe Glu
145                 150                 155                 160 
Ile Gln Glu Glu Ser Lys Gln Phe Val Ala Arg Tyr Gly Lys Val Ser
                165                 170                 175     
Ala Gly Glu Ile Ala Val Thr Gly Ala Gly Arg Leu Pro Cys Lys Gln
            180                 185                 190         
Ile Ile His Ala Val Gly Pro Arg Trp Met Glu Trp Asp Lys Gln Gly
        195                 200                 205             
Cys Thr Gly Lys Leu Gln Arg Ala Ile Val Ser Ile Leu Asn Tyr Val
    210                 215                 220                 
Ile Tyr Lys Asn Thr His Ile Lys Thr Val Ala Ile Pro Ala Leu Ser
225                 230                 235                 240 
Ser Gly Ile Phe Gln Phe Pro Leu Asn Leu Cys Thr Lys Thr Ile Val
                245                 250                 255     
Glu Thr Ile Arg Val Ser Leu Gln Gly Lys Pro Met Met Ser Asn Leu
            260                 265                 270         
Lys Glu Ile His Leu Val Ser Asn Glu Asp Pro Thr Val Ala Ala Phe
        275                 280                 285             
Lys Ala Ala Ser Glu Phe Ile Leu Gly Lys Ser Glu Leu Gly Gln Glu
    290                 295                 300                 
Thr Thr Pro Ser Phe Asn Ala Met Val Val Asn Asn Leu Thr Leu Gln
305                 310                 315                 320 
Ile Val Gln Gly His Ile Glu Trp Gln Thr Ala Asp Val Ile Val Asn
                325                 330                 335     
Ser Val Asn Pro His Asp Ile Thr Val Gly Pro Val Ala Lys Ser Ile
            340                 345                 350         
Leu Gln Gln Ala Gly Val Glu Met Lys Ser Glu Phe Leu Ala Thr Lys
        355                 360                 365             
Ala Lys Gln Phe Gln Arg Ser Gln Leu Val Leu Val Thr Lys Gly Phe
    370                 375                 380                 
Asn Leu Phe Cys Lys Tyr Ile Tyr His Val Leu Trp His Ser Glu Phe
385                 390                 395                 400 
Pro Lys Pro Gln Ile Leu Lys His Ala Met Lys Glu Cys Leu Glu Lys
                405                 410                 415     
Cys Ile Glu Gln Asn Ile Thr Ser Ile Ser Phe Pro Ala Leu Gly Thr
            420                 425                 430         
Gly Asn Met Glu Ile Lys Lys Glu Thr Ala Ala Glu Ile Leu Phe Asp
        435                 440                 445             
Glu Val Leu Thr Phe Ala Lys Asp His Val Lys His Gln Leu Thr Val
    450                 455                 460                 
Lys Phe Val Ile Phe Pro Thr Asp Leu Glu Ile Tyr Lys Ala Phe Ser
465                 470                 475                 480 
Ser Glu Met Ala Lys Arg Ser Lys Met Leu Ser Leu Asn Asn Tyr Ser
                485                 490                 495     
Val Pro Gln Ser Thr Arg Glu Glu Lys Arg Glu Asn Gly Leu Glu Ala
            500                 505                 510         
Arg Ser Pro Ala Ile Asn Leu Met Gly Phe Asn Val Glu Glu Met Tyr
        515                 520                 525             
Glu Ala His Ala Trp Ile Gln Arg Ile Leu Ser Leu Gln Asn His His
    530                 535                 540                 
Ile Ile Glu Asn Asn His Ile Leu Tyr Leu Gly Arg Lys Glu His Asp
545                 550                 555                 560 
Ile Leu Ser Gln Leu Gln Lys Thr Ser Ser Val Ser Ile Thr Glu Ile
                565                 570                 575     
Ile Ser Pro Gly Arg Thr Glu Leu Glu Ile Glu Gly Ala Arg Ala Asp
            580                 585                 590         
Leu Ile Glu Val Val Met Asn Ile Glu Asp Met Leu Cys Lys Val Gln
        595                 600                 605             
Glu Glu Met Ala Arg Lys Lys Glu Arg Gly Leu Trp Arg Ser Leu Gly
    610                 615                 620                 
Gln Trp Thr Ile Gln Gln Gln Lys Thr Gln Asp Glu Met Lys Glu Asn
625                 630                 635                 640 
Ile Ile Phe Leu Lys Cys Pro Val Pro Pro Thr Gln Glu Leu Leu Asp
                645                 650                 655     
Gln Lys Lys Gln Phe Glu Lys Cys Gly Leu Gln Val Leu Lys Val Glu
            660                 665                 670         
Lys Ile Asp Asn Glu Val Leu Met Ala Ala Phe Gln Arg Lys Lys Lys
        675                 680                 685             
Met Met Glu Glu Lys Leu His Arg Gln Pro Val Ser His Arg Leu Phe
    690                 695                 700                 
Gln Gln Val Pro Tyr Gln Phe Cys Asn Val Val Cys Arg Val Gly Phe
705                 710                 715                 720 
Gln Arg Met Tyr Ser Thr Pro Cys Asp Pro Lys Tyr Gly Ala Gly Ile
                725                 730                 735     
Tyr Phe Thr Lys Asn Leu Lys Asn Leu Ala Glu Lys Ala Lys Lys Ile
            740                 745                 750         
Ser Ala Ala Asp Lys Leu Ile Tyr Val Phe Glu Ala Glu Val Leu Thr
        755                 760                 765             
Gly Phe Phe Cys Gln Gly His Pro Leu Asn Ile Val Pro Pro Pro Leu
    770                 775                 780                 
Ser Pro Gly Ala Ile Asp Gly His Asp Ser Val Val Asp Asn Val Ser
785                 790                 795                 800 
Ser Pro Glu Thr Phe Val Ile Phe Ser Gly Met Gln Ala Ile Pro Gln
                805                 810                 815     
Tyr Leu Trp Thr Cys Thr Gln Glu Tyr Val Gln Ser Gln Asp Tyr Ser
            820                 825                 830         
Ser Gly Pro Met Arg Pro Phe Ala Gln His Pro Trp Arg Gly Phe Ala
        835                 840                 845             
Ser Gly Ser Pro Val Asp
    850                 


<210> 8162
<211> 819
<212> PRT
<213> Homo sapiens

<400> 8162
Met Asp Phe Ser Met Val Ala Gly Ala Ala Ala Tyr Asn Glu Lys Ser
 1               5                  10                  15      
Glu Thr Gly Ala Leu Gly Glu Asn Tyr Ser Trp Gln Ile Pro Ile Asn
            20                  25                  30          
His Asn Asp Phe Lys Ile Leu Lys Asn Asn Glu Arg Gln Leu Cys Glu
        35                  40                  45              
Val Leu Gln Asn Lys Phe Gly Cys Ile Ser Thr Leu Val Ser Pro Val
    50                  55                  60                  
Gln Glu Gly Asn Ser Lys Ser Leu Gln Val Phe Arg Lys Met Leu Thr
65                  70                  75                  80  
Pro Arg Ile Glu Leu Ser Val Trp Lys Asp Asp Leu Thr Thr His Ala
                85                  90                  95      
Val Asp Ala Val Val Asn Ala Ala Asn Glu Asp Leu Leu His Gly Gly
            100                 105                 110         
Gly Leu Ala Leu Ala Leu Val Lys Ala Gly Gly Phe Glu Ile Gln Glu
        115                 120                 125             
Glu Ser Lys Gln Phe Val Ala Arg Tyr Gly Lys Val Ser Ala Gly Glu
    130                 135                 140                 
Ile Ala Val Thr Gly Ala Gly Arg Leu Pro Cys Lys Gln Ile Ile His
145                 150                 155                 160 
Ala Val Gly Pro Arg Trp Met Glu Trp Asp Lys Gln Gly Cys Thr Gly
                165                 170                 175     
Lys Leu Gln Arg Ala Ile Val Ser Ile Leu Asn Tyr Val Ile Tyr Lys
            180                 185                 190         
Asn Thr His Ile Lys Thr Val Ala Ile Pro Ala Leu Ser Ser Gly Ile
        195                 200                 205             
Phe Gln Phe Pro Leu Asn Leu Cys Thr Lys Thr Ile Val Glu Thr Ile
    210                 215                 220                 
Arg Val Ser Leu Gln Gly Lys Pro Met Met Ser Asn Leu Lys Glu Ile
225                 230                 235                 240 
His Leu Val Ser Asn Glu Asp Pro Thr Val Ala Ala Phe Lys Ala Ala
                245                 250                 255     
Ser Glu Phe Ile Leu Gly Lys Ser Glu Leu Gly Gln Glu Thr Thr Pro
            260                 265                 270         
Ser Phe Asn Ala Met Val Val Asn Asn Leu Thr Leu Gln Ile Val Gln
        275                 280                 285             
Gly His Ile Glu Trp Gln Thr Ala Asp Val Ile Val Asn Ser Val Asn
    290                 295                 300                 
Pro His Asp Ile Thr Val Gly Pro Val Ala Lys Ser Ile Leu Gln Gln
305                 310                 315                 320 
Ala Gly Val Glu Met Lys Ser Glu Phe Leu Ala Thr Lys Ala Lys Gln
                325                 330                 335     
Phe Gln Arg Ser Gln Leu Val Leu Val Thr Lys Gly Phe Asn Leu Phe
            340                 345                 350         
Cys Lys Tyr Ile Tyr His Val Leu Trp His Ser Glu Phe Pro Lys Pro
        355                 360                 365             
Gln Ile Leu Lys His Ala Met Lys Glu Cys Leu Glu Lys Cys Ile Glu
    370                 375                 380                 
Gln Asn Ile Thr Ser Ile Ser Phe Pro Ala Leu Gly Thr Gly Asn Met
385                 390                 395                 400 
Glu Ile Lys Lys Glu Thr Ala Ala Glu Ile Leu Phe Asp Glu Val Leu
                405                 410                 415     
Thr Phe Ala Lys Asp His Val Lys His Gln Leu Thr Val Lys Phe Val
            420                 425                 430         
Ile Phe Pro Thr Asp Leu Glu Ile Tyr Lys Ala Phe Ser Ser Glu Met
        435                 440                 445             
Ala Lys Arg Ser Lys Met Leu Ser Leu Asn Asn Tyr Ser Val Pro Gln
    450                 455                 460                 
Ser Thr Arg Glu Glu Lys Arg Glu Asn Gly Leu Glu Ala Arg Ser Pro
465                 470                 475                 480 
Ala Ile Asn Leu Met Gly Phe Asn Val Glu Glu Met Tyr Glu Ala His
                485                 490                 495     
Ala Trp Ile Gln Arg Ile Leu Ser Leu Gln Asn His His Ile Ile Glu
            500                 505                 510         
Asn Asn His Ile Leu Tyr Leu Gly Arg Lys Glu His Asp Ile Leu Ser
        515                 520                 525             
Gln Leu Gln Lys Thr Ser Ser Val Ser Ile Thr Glu Ile Ile Ser Pro
    530                 535                 540                 
Gly Arg Thr Glu Leu Glu Ile Glu Gly Ala Arg Ala Asp Leu Ile Glu
545                 550                 555                 560 
Val Val Met Asn Ile Glu Asp Met Leu Cys Lys Val Gln Glu Glu Met
                565                 570                 575     
Ala Arg Lys Lys Glu Arg Gly Leu Trp Arg Ser Leu Gly Gln Trp Thr
            580                 585                 590         
Ile Gln Gln Gln Lys Thr Gln Asp Glu Met Lys Glu Asn Ile Ile Phe
        595                 600                 605             
Leu Lys Cys Pro Val Pro Pro Thr Gln Glu Leu Leu Asp Gln Lys Lys
    610                 615                 620                 
Gln Phe Glu Lys Cys Gly Leu Gln Val Leu Lys Val Glu Lys Ile Asp
625                 630                 635                 640 
Asn Glu Val Leu Met Ala Ala Phe Gln Arg Lys Lys Lys Met Met Glu
                645                 650                 655     
Glu Lys Leu His Arg Gln Pro Val Ser His Arg Leu Phe Gln Gln Val
            660                 665                 670         
Pro Tyr Gln Phe Cys Asn Val Val Cys Arg Val Gly Phe Gln Arg Met
        675                 680                 685             
Tyr Ser Thr Pro Cys Asp Pro Lys Tyr Gly Ala Gly Ile Tyr Phe Thr
    690                 695                 700                 
Lys Asn Leu Lys Asn Leu Ala Glu Lys Ala Lys Lys Ile Ser Ala Ala
705                 710                 715                 720 
Asp Lys Leu Ile Tyr Val Phe Glu Ala Glu Val Leu Thr Gly Phe Phe
                725                 730                 735     
Cys Gln Gly His Pro Leu Asn Ile Val Pro Pro Pro Leu Ser Pro Gly
            740                 745                 750         
Ala Ile Asp Gly His Asp Ser Val Val Asp Asn Val Ser Ser Pro Glu
        755                 760                 765             
Thr Phe Val Ile Phe Ser Gly Met Gln Ala Ile Pro Gln Tyr Leu Trp
    770                 775                 780                 
Thr Cys Thr Gln Glu Tyr Val Gln Ser Gln Asp Tyr Ser Ser Gly Pro
785                 790                 795                 800 
Met Arg Pro Phe Ala Gln His Pro Trp Arg Gly Phe Ala Ser Gly Ser
                805                 810                 815     
Pro Val Asp
            


<210> 8163
<211> 449
<212> PRT
<213> Homo sapiens

<400> 8163
Met Leu Trp Lys Leu Val Glu Asn Val Lys Tyr Glu Asp Ile Tyr Glu
 1               5                  10                  15      
Asp Arg His Asp Gly Val Pro Ser His Ser Ser Arg Leu Ser Gln Leu
            20                  25                  30          
Gly Ser Val Ser Gln Gly Pro Tyr Ser Ser Ala Pro Pro Leu Ser His
        35                  40                  45              
Thr Pro Ser Ser Asp Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Gln
    50                  55                  60                  
Pro Leu Pro Tyr His Gln Ser Gln Asp Pro Tyr Ser His Val Asn Asp
65                  70                  75                  80  
Pro Tyr Ser Leu Asn Pro Leu His Gln Pro Gln Gln His Pro Trp Gly
                85                  90                  95      
Gln Arg Gln Arg Gln Glu Val Gly Ser Glu Ala Gly Ser Leu Leu Pro
            100                 105                 110         
Gln Pro Arg Ala Ala Leu Pro Gln Leu Ser Gly Leu Asp Pro Arg Arg
        115                 120                 125             
Asp Tyr His Ser Val Arg Arg Pro Asp Val Leu Leu His Ser Ala His
    130                 135                 140                 
His Gly Leu Asp Ala Gly Met Gly Asp Ser Leu Ser Leu His Gly Leu
145                 150                 155                 160 
Gly His Pro Gly Met Glu Asp Val Gln Ser Val Glu Asp Ala Asn Asn
                165                 170                 175     
Ser Gly Met Asn Leu Leu Asp Gln Ser Val Ile Lys Lys Val Pro Val
            180                 185                 190         
Pro Pro Lys Ser Val Thr Ser Leu Met Met Asn Lys Asp Gly Phe Leu
        195                 200                 205             
Gly Gly Met Ser Val Asn Thr Gly Glu Val Phe Cys Ser Val Pro Gly
    210                 215                 220                 
Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys Val Thr Val Gly
225                 230                 235                 240 
Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu Asn Ala Ser Leu
                245                 250                 255     
Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn Gly Gly Arg Ser
            260                 265                 270         
Leu Arg Glu Arg Leu Glu Lys Ile Gly Leu Asn Leu Pro Ala Gly Arg
        275                 280                 285             
Arg Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu Val Glu Gly Glu
    290                 295                 300                 
Ala Val His Leu Ala Arg Asp Phe Gly Tyr Ile Cys Glu Thr Glu Phe
305                 310                 315                 320 
Pro Ala Lys Ala Val Ser Glu Tyr Leu Asn Arg Gln His Thr Asp Pro
                325                 330                 335     
Ser Asp Leu His Ser Arg Lys Asn Met Leu Leu Ala Thr Lys Gln Leu
            340                 345                 350         
Cys Lys Glu Phe Thr Asp Leu Leu Ala Gln Asp Arg Thr Pro Ile Gly
        355                 360                 365             
Asn Ser Arg Pro Ser Pro Ile Leu Glu Pro Gly Ile Gln Ser Cys Leu
    370                 375                 380                 
Thr His Phe Ser Leu Ile Thr His Gly Phe Gly Ala Pro Ala Ile Cys
385                 390                 395                 400 
Ala Ala Leu Thr Ala Leu Gln Asn Tyr Leu Thr Glu Ala Leu Lys Gly
                405                 410                 415     
Met Asp Lys Met Phe Leu Asn Asn Thr Thr Thr Asn Arg His Thr Ser
            420                 425                 430         
Gly Glu Gly Pro Gly Ser Lys Thr Gly Asp Lys Glu Glu Lys His Arg
        435                 440                 445             
Lys
    


<210> 8164
<211> 458
<212> PRT
<213> Homo sapiens

<400> 8164
Met Leu Trp Lys Leu Val Glu Asn Val Lys Tyr Glu Asp Ile Tyr Glu
 1               5                  10                  15      
Met Leu Val His Thr Tyr Ser Ser Met Asp Arg His Asp Gly Val Pro
            20                  25                  30          
Ser His Ser Ser Arg Leu Ser Gln Leu Gly Ser Val Ser Gln Gly Pro
        35                  40                  45              
Tyr Ser Ser Ala Pro Pro Leu Ser His Thr Pro Ser Ser Asp Phe Gln
    50                  55                  60                  
Pro Pro Tyr Phe Pro Pro Pro Tyr Gln Pro Leu Pro Tyr His Gln Ser
65                  70                  75                  80  
Gln Asp Pro Tyr Ser His Val Asn Asp Pro Tyr Ser Leu Asn Pro Leu
                85                  90                  95      
His Gln Pro Gln Gln His Pro Trp Gly Gln Arg Gln Arg Gln Glu Val
            100                 105                 110         
Gly Ser Glu Ala Gly Ser Leu Leu Pro Gln Pro Arg Ala Ala Leu Pro
        115                 120                 125             
Gln Leu Ser Gly Leu Asp Pro Arg Arg Asp Tyr His Ser Val Arg Arg
    130                 135                 140                 
Pro Asp Val Leu Leu His Ser Ala His His Gly Leu Asp Ala Gly Met
145                 150                 155                 160 
Gly Asp Ser Leu Ser Leu His Gly Leu Gly His Pro Gly Met Glu Asp
                165                 170                 175     
Val Gln Ser Val Glu Asp Ala Asn Asn Ser Gly Met Asn Leu Leu Asp
            180                 185                 190         
Gln Ser Val Ile Lys Lys Val Pro Val Pro Pro Lys Ser Val Thr Ser
        195                 200                 205             
Leu Met Met Asn Lys Asp Gly Phe Leu Gly Gly Met Ser Val Asn Thr
    210                 215                 220                 
Gly Glu Val Phe Cys Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser
225                 230                 235                 240 
Thr Ser Lys Tyr Lys Val Thr Val Gly Glu Val Gln Arg Arg Leu Ser
                245                 250                 255     
Pro Pro Glu Cys Leu Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg
            260                 265                 270         
Ala Lys Ser Lys Asn Gly Gly Arg Ser Leu Arg Glu Arg Leu Glu Lys
        275                 280                 285             
Ile Gly Leu Asn Leu Pro Ala Gly Arg Arg Lys Ala Ala Asn Val Thr
    290                 295                 300                 
Leu Leu Thr Ser Leu Val Glu Gly Glu Ala Val His Leu Ala Arg Asp
305                 310                 315                 320 
Phe Gly Tyr Ile Cys Glu Thr Glu Phe Pro Ala Lys Ala Val Ser Glu
                325                 330                 335     
Tyr Leu Asn Arg Gln His Thr Asp Pro Ser Asp Leu His Ser Arg Lys
            340                 345                 350         
Asn Met Leu Leu Ala Thr Lys Gln Leu Cys Lys Glu Phe Thr Asp Leu
        355                 360                 365             
Leu Ala Gln Asp Arg Thr Pro Ile Gly Asn Ser Arg Pro Ser Pro Ile
    370                 375                 380                 
Leu Glu Pro Gly Ile Gln Ser Cys Leu Thr His Phe Ser Leu Ile Thr
385                 390                 395                 400 
His Gly Phe Gly Ala Pro Ala Ile Cys Ala Ala Leu Thr Ala Leu Gln
                405                 410                 415     
Asn Tyr Leu Thr Glu Ala Leu Lys Gly Met Asp Lys Met Phe Leu Asn
            420                 425                 430         
Asn Thr Thr Thr Asn Arg His Thr Ser Gly Glu Gly Pro Gly Ser Lys
        435                 440                 445             
Thr Gly Asp Lys Glu Glu Lys His Arg Lys
    450                 455             


<210> 8165
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8165
Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met
 1               5                  10                  15      
Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu
            20                  25                  30          
Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly
        35                  40                  45              
Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser
    50                  55                  60                  
Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu
65                  70                  75                  80  
Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu
                85                  90                  95      
Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe
            100                 105                 110         
Tyr Pro Leu Gly Ile Val Gln His Asp
        115                 120     


<210> 8166
<211> 336
<212> PRT
<213> Homo sapiens

<400> 8166
Met Ser Phe Phe Gly Phe Gly Gln Ser Val Glu Val Glu Ile Leu Leu
 1               5                  10                  15      
Asn Asp Ala Glu Ser Arg Lys Arg Ala Glu His Lys Thr Glu Asp Gly
            20                  25                  30          
Lys Lys Glu Lys Tyr Phe Leu Phe Tyr Asp Gly Glu Thr Val Ser Gly
        35                  40                  45              
Lys Val Ser Leu Ala Leu Lys Asn Pro Asn Lys Arg Leu Glu His Gln
    50                  55                  60                  
Gly Ile Lys Ile Glu Phe Ile Gly Gln Ile Glu Leu Tyr Tyr Asp Arg
65                  70                  75                  80  
Gly Asn His His Glu Phe Val Ser Leu Val Lys Asp Leu Ala Arg Pro
                85                  90                  95      
Gly Glu Ile Thr Gln Ser Gln Ala Phe Asp Phe Glu Phe Thr His Val
            100                 105                 110         
Glu Lys Pro Tyr Glu Ser Tyr Thr Gly Gln Asn Val Lys Leu Arg Tyr
        115                 120                 125             
Phe Leu Arg Ala Thr Ile Ser Arg Arg Leu Asn Asp Val Val Lys Glu
    130                 135                 140                 
Met Asp Ile Val Val His Thr Leu Ser Thr Tyr Pro Glu Leu Asn Ser
145                 150                 155                 160 
Ser Ile Lys Met Glu Val Gly Ile Glu Asp Cys Leu His Ile Glu Phe
                165                 170                 175     
Glu Tyr Asn Lys Ser Lys Tyr His Leu Lys Asp Val Ile Val Gly Lys
            180                 185                 190         
Ile Tyr Phe Leu Leu Val Arg Ile Lys Ile Lys His Met Glu Ile Asp
        195                 200                 205             
Ile Ile Lys Arg Glu Thr Thr Gly Thr Gly Pro Asn Val Tyr His Glu
    210                 215                 220                 
Asn Asp Thr Ile Ala Lys Tyr Glu Ile Met Asp Gly Ala Pro Val Arg
225                 230                 235                 240 
Gly Glu Ser Ile Pro Ile Arg Leu Phe Leu Ala Gly Tyr Glu Leu Thr
                245                 250                 255     
Pro Thr Met Arg Asp Ile Asn Lys Lys Phe Ser Val Arg Tyr Tyr Leu
            260                 265                 270         
Asn Leu Val Leu Ile Asp Glu Glu Glu Arg Arg Tyr Phe Lys Gln Gln
        275                 280                 285             
Glu Val Val Leu Trp Arg Lys Gly Asp Ile Val Arg Lys Ser Met Ser
    290                 295                 300                 
His Gln Ala Ala Ile Ala Ser Gln Arg Phe Glu Gly Thr Thr Ser Leu
305                 310                 315                 320 
Gly Glu Val Arg Thr Pro Ser Gln Leu Ser Asp Asn Asn Cys Arg Gln
                325                 330                 335     


<210> 8167
<211> 366
<212> PRT
<213> Homo sapiens

<400> 8167
Arg Val Arg Gly Gly Pro Arg Ser Arg Asp Gly Ala Pro Glu Arg Arg
 1               5                  10                  15      
Glu Pro Gly Leu Gly Val Leu Leu Arg Glu Glu Glu Trp Ser Arg Gly
            20                  25                  30          
Asp Ala Ala Ala Ala Leu Thr Met Ser Phe Leu Gly Gly Phe Phe Gly
        35                  40                  45              
Pro Ile Cys Glu Ile Asp Ile Val Leu Asn Asp Gly Glu Thr Arg Lys
    50                  55                  60                  
Met Ala Glu Met Lys Thr Glu Asp Gly Lys Val Glu Lys His Tyr Leu
65                  70                  75                  80  
Phe Tyr Asp Gly Glu Ser Val Ser Gly Lys Val Asn Leu Ala Phe Lys
                85                  90                  95      
Gln Pro Gly Lys Arg Leu Glu His Gln Gly Ile Arg Ile Glu Phe Val
            100                 105                 110         
Gly Gln Ile Glu Leu Phe Asn Asp Lys Ser Asn Thr His Glu Phe Val
        115                 120                 125             
Asn Leu Val Lys Glu Leu Ala Leu Pro Gly Glu Leu Thr Gln Ser Arg
    130                 135                 140                 
Ser Tyr Asp Phe Glu Phe Met Gln Val Glu Lys Pro Tyr Glu Ser Tyr
145                 150                 155                 160 
Ile Gly Ala Asn Val Arg Leu Arg Tyr Phe Leu Lys Val Thr Ile Val
                165                 170                 175     
Arg Arg Leu Thr Asp Leu Val Lys Glu Tyr Asp Leu Ile Val His Gln
            180                 185                 190         
Leu Ala Thr Tyr Pro Asp Val Asn Asn Ser Ile Lys Met Glu Val Gly
        195                 200                 205             
Ile Glu Asp Cys Leu His Ile Glu Phe Glu Tyr Asn Lys Ser Lys Tyr
    210                 215                 220                 
His Leu Lys Asp Val Ile Val Gly Lys Ile Tyr Phe Leu Leu Val Arg
225                 230                 235                 240 
Ile Lys Ile Gln His Met Glu Leu Gln Leu Ile Lys Lys Glu Ile Thr
                245                 250                 255     
Gly Ile Gly Pro Ser Thr Thr Thr Glu Thr Glu Thr Ile Ala Lys Tyr
            260                 265                 270         
Glu Ile Met Asp Gly Ala Pro Val Lys Gly Glu Ser Ile Pro Ile Arg
        275                 280                 285             
Leu Phe Leu Ala Gly Tyr Asp Pro Thr Pro Thr Met Arg Asp Val Asn
    290                 295                 300                 
Lys Lys Phe Ser Val Arg Tyr Phe Leu Asn Leu Val Leu Val Asp Glu
305                 310                 315                 320 
Glu Asp Arg Arg Tyr Phe Lys Gln Gln Glu Ile Ile Leu Trp Arg Lys
                325                 330                 335     
Ala Pro Glu Lys Leu Arg Lys Gln Arg Thr Asn Phe His Gln Arg Phe
            340                 345                 350         
Glu Ser Pro Glu Ser Gln Ala Ser Ala Glu Gln Pro Glu Met
        355                 360                 365     


<210> 8168
<211> 222
<212> PRT
<213> Homo sapiens

<400> 8168
Met Ser Leu Lys Met Asp Asn Arg Asp Val Ala Gly Lys Ala Asn Arg
 1               5                  10                  15      
Trp Phe Gly Val Ala Pro Pro Lys Ser Gly Lys Met Asn Met Asn Ile
            20                  25                  30          
Leu His Gln Glu Glu Leu Ile Ala Gln Lys Lys Arg Glu Ile Glu Ala
        35                  40                  45              
Lys Met Glu Gln Lys Ala Lys Gln Asn Gln Val Ala Ser Pro Gln Pro
    50                  55                  60                  
Pro His Pro Gly Glu Ile Thr Asn Ala His Asn Ser Ser Cys Ile Ser
65                  70                  75                  80  
Asn Lys Phe Ala Asn Asp Gly Ser Phe Leu Gln Gln Phe Leu Lys Leu
                85                  90                  95      
Gln Lys Ala Gln Thr Ser Thr Asp Ala Pro Thr Ser Ala Pro Ser Ala
            100                 105                 110         
Pro Pro Ser Thr Pro Thr Pro Ser Ala Gly Lys Arg Ser Leu Leu Ile
        115                 120                 125             
Ser Arg Arg Thr Gly Leu Gly Leu Ala Ser Leu Pro Gly Pro Val Lys
    130                 135                 140                 
Ser Tyr Ser His Ala Lys Gln Leu Pro Val Ala His Arg Pro Ser Val
145                 150                 155                 160 
Phe Gln Ser Pro Asp Glu Asp Glu Glu Glu Asp Tyr Glu Gln Trp Leu
                165                 170                 175     
Glu Ile Lys Val Cys Leu Thr Lys Thr Val Arg Pro Thr Pro Pro Ser
            180                 185                 190         
Ser Trp Cys Phe Val Pro Gly Leu Gly Thr Pro Asp Ser Leu Leu His
        195                 200                 205             
Leu Thr Leu Phe Ser Pro His Pro Leu Cys Arg Cys Gly Pro
    210                 215                 220         


<210> 8169
<211> 645
<212> PRT
<213> Homo sapiens

<400> 8169
Met Ser Leu Lys Met Asp Asn Arg Asp Val Ala Gly Lys Ala Asn Arg
 1               5                  10                  15      
Trp Phe Gly Val Ala Pro Pro Lys Ser Gly Lys Met Asn Met Asn Ile
            20                  25                  30          
Leu His Gln Glu Glu Leu Ile Ala Gln Lys Lys Arg Glu Ile Glu Ala
        35                  40                  45              
Lys Met Glu Gln Lys Ala Lys Gln Asn Gln Val Ala Ser Pro Gln Pro
    50                  55                  60                  
Pro His Pro Gly Glu Ile Thr Asn Ala His Asn Ser Ser Cys Ile Ser
65                  70                  75                  80  
Asn Lys Phe Ala Asn Asp Gly Ser Phe Leu Gln Gln Phe Leu Lys Leu
                85                  90                  95      
Gln Lys Ala Gln Thr Ser Thr Asp Ala Pro Thr Ser Ala Pro Ser Ala
            100                 105                 110         
Pro Pro Ser Thr Pro Thr Pro Ser Ala Gly Lys Arg Ser Leu Leu Ile
        115                 120                 125             
Ser Arg Arg Thr Gly Leu Gly Leu Ala Ser Leu Pro Gly Pro Val Lys
    130                 135                 140                 
Ser Tyr Ser His Ala Lys Gln Leu Pro Val Ala His Arg Pro Ser Val
145                 150                 155                 160 
Phe Gln Ser Pro Asp Glu Asp Glu Glu Glu Asp Tyr Glu Gln Trp Leu
                165                 170                 175     
Glu Ile Lys Val Ser Pro Pro Glu Gly Ala Glu Thr Arg Lys Val Ile
            180                 185                 190         
Glu Lys Leu Ala Arg Phe Val Ala Glu Gly Gly Pro Glu Leu Glu Lys
        195                 200                 205             
Val Ala Met Glu Asp Tyr Lys Asp Asn Pro Ala Phe Ala Phe Leu His
    210                 215                 220                 
Asp Lys Asn Ser Arg Glu Phe Leu Tyr Tyr Arg Lys Lys Val Ala Glu
225                 230                 235                 240 
Ile Arg Lys Glu Ala Gln Lys Ser Gln Ala Ala Ser Gln Lys Val Ser
                245                 250                 255     
Pro Pro Glu Asp Glu Glu Val Lys Asn Leu Ala Glu Lys Leu Ala Arg
            260                 265                 270         
Phe Ile Ala Asp Gly Gly Pro Glu Val Glu Thr Ile Ala Leu Gln Asn
        275                 280                 285             
Asn Arg Glu Asn Gln Ala Phe Ser Phe Leu Tyr Glu Pro Asn Ser Gln
    290                 295                 300                 
Gly Tyr Lys Tyr Tyr Arg Gln Lys Leu Glu Glu Phe Arg Lys Ala Lys
305                 310                 315                 320 
Ala Ser Ser Thr Gly Ser Phe Thr Ala Pro Asp Pro Gly Leu Lys Arg
                325                 330                 335     
Lys Ser Pro Pro Glu Ala Leu Ser Gly Ser Leu Pro Pro Ala Thr Thr
            340                 345                 350         
Cys Pro Ala Ser Ser Thr Pro Ala Pro Thr Ile Ile Pro Ala Pro Ala
        355                 360                 365             
Ala Pro Gly Lys Pro Ala Ser Ala Ala Thr Val Lys Arg Lys Arg Lys
    370                 375                 380                 
Ser Arg Trp Gly Pro Glu Glu Asp Lys Val Glu Leu Pro Pro Ala Glu
385                 390                 395                 400 
Leu Val Gln Arg Asp Val Asp Ala Ser Pro Ser Pro Leu Ser Val Gln
                405                 410                 415     
Asp Leu Lys Gly Leu Gly Tyr Glu Lys Gly Lys Pro Val Gly Leu Val
            420                 425                 430         
Gly Val Thr Glu Leu Ser Asp Ala Gln Lys Lys Gln Leu Lys Glu Gln
        435                 440                 445             
Gln Glu Met Gln Gln Met Tyr Asp Met Ile Met Gln His Lys Arg Ala
    450                 455                 460                 
Met Gln Asp Met Gln Leu Leu Trp Glu Lys Ala Val Gln Gln His Gln
465                 470                 475                 480 
His Gly Tyr Asp Ser Asp Glu Glu Val Asp Ser Glu Leu Gly Thr Trp
                485                 490                 495     
Lys His Gln Leu Arg Arg Met Glu Met Asp Lys Thr Arg Glu Trp Ala
            500                 505                 510         
Glu Gln Leu Thr Lys Met Gly Arg Gly Lys His Phe Ile Gly Asp Phe
        515                 520                 525             
Leu Pro Pro Asp Glu Leu Glu Lys Phe Met Glu Thr Phe Lys Ala Leu
    530                 535                 540                 
Lys Glu Gly Arg Glu Pro Asp Tyr Ser Glu Tyr Lys Glu Phe Lys Leu
545                 550                 555                 560 
Thr Val Glu Asn Ile Gly Tyr Gln Met Leu Met Lys Met Gly Trp Lys
                565                 570                 575     
Glu Gly Glu Gly Leu Gly Ser Glu Gly Gln Gly Ile Lys Asn Pro Val
            580                 585                 590         
Asn Lys Gly Thr Thr Thr Val Asp Gly Ala Gly Phe Gly Ile Asp Arg
        595                 600                 605             
Pro Ala Glu Leu Ser Lys Glu Asp Asp Glu Tyr Glu Ala Phe Arg Lys
    610                 615                 620                 
Arg Met Met Leu Ala Tyr Arg Phe Arg Pro Asn Pro Leu Asn Asn Pro
625                 630                 635                 640 
Arg Arg Pro Tyr Tyr
                645 


<210> 8170
<211> 1010
<212> PRT
<213> Homo sapiens

<400> 8170
Met Tyr Ser Gln Glu Asp His Ile Phe Gln Leu Cys Ser Thr Asp Leu
 1               5                  10                  15      
Cys Ala Ser Tyr Val Pro Val Ile Asn Gln Ser Val Leu Val Thr His
            20                  25                  30          
Ile Val Asn Tyr Glu Asp Tyr Leu Gln Ile Gln Ala Ser Pro Leu Gln
        35                  40                  45              
Thr Ser Gln Pro Thr Pro Pro Glu Glu Leu His Thr Val Gly Tyr Val
    50                  55                  60                  
Phe Thr Asn Asp Gly Gln Gln Thr Arg Ser Asp Glu Val Asn Gln Val
65                  70                  75                  80  
Ala Thr Gly His Gln Ser Lys Gln Lys Arg Ser Arg Glu Ser Lys Arg
                85                  90                  95      
His Ser Ser Ser Lys Arg Arg Lys Ser Met Ser Arg Trp Leu Asn Lys
            100                 105                 110         
Gln Glu Asp Ala Ala Val Thr His Ile Val Cys Glu Glu Lys Ile Asn
        115                 120                 125             
Asn Asp Gln Pro Ala Pro Asp Asn Val Leu Ser Thr Ala Pro Pro Trp
    130                 135                 140                 
Leu Arg Asp Met Ala Ala Ala Gly Ile Ser Ser Thr Ser Thr Arg Asp
145                 150                 155                 160 
Leu Tyr Ala Thr Val Thr His Asn Val Cys Asp Glu Arg Met Glu Asn
                165                 170                 175     
Asp Gln Leu Gln Leu Asn Asn Val Leu Leu Thr Phe Pro Pro Glu Arg
            180                 185                 190         
Val Asn Met Ala Val Ala Asp Phe Ser Ala Met Ser Pro Arg Asp Leu
        195                 200                 205             
Tyr Ala Thr Ile Asn His Asn Val Tyr Glu Val Arg Met Glu Asn Asn
    210                 215                 220                 
Gln Pro Gln Phe Asn Asn Val Leu Ser Thr Val Lys Pro Gly His Ile
225                 230                 235                 240 
Asn Met Ala Ala Ala Gly Ile Pro Ala Met Ser Ala Lys Gly Leu Tyr
                245                 250                 255     
Ala Val Val Asn Leu Asn Val His Gly Glu Lys Ile Asn Lys Gly Gln
            260                 265                 270         
Pro Ala Pro Asp Asn Phe Leu Ser Ser Val Thr Pro Gly Leu Ile Asn
        275                 280                 285             
Val Ser Gly Asp Gly Ala Thr Val Thr His Asn Ala Tyr Glu Glu Lys
    290                 295                 300                 
Met Glu Asn Gly Gln Gln Ala Ala Asp Asn Ile Leu Ser Ala Val Pro
305                 310                 315                 320 
Pro Gly Leu Ile Asn Thr Ser Glu Ala Gly Ile Pro Ala Met Ser Thr
                325                 330                 335     
Asn Asp Leu Tyr Ala Thr Ile Thr His Asp Val Ser Glu Lys Lys Ile
            340                 345                 350         
Lys Asn Ser Gln Pro Ala Thr Asp Asn Phe Leu Cys Thr Val Thr Pro
        355                 360                 365             
Gly Leu Ile Asn Leu Ala Glu Ala Gly Ile Leu Ala Thr Ser Thr Arg
    370                 375                 380                 
Asp Leu Tyr Asp Thr Ala Thr His Asn Val His Glu Glu Lys Met Lys
385                 390                 395                 400 
Asn Lys His Leu Ile Thr Pro Cys Gln Gln Phe His Trp Asp Leu Leu
                405                 410                 415     
Ile Cys Gln Glu Leu Leu Asn Phe Phe Ile Trp Ile Pro Asp Ala Thr
            420                 425                 430         
Val Ile His Asn Ile Gln Glu Glu Glu Met Glu Asn Gly Gln Met Pro
        435                 440                 445             
Pro Asp Gly Phe Leu Ser Asn Ser Ala Pro Leu Glu Leu Ile Asn Met
    450                 455                 460                 
Thr Glu Asp Cys Met Pro Leu Asn Ala Leu Asp Ser Phe Ser Tyr Asp
465                 470                 475                 480 
Phe Thr Ser Leu Ser Arg Glu Glu Leu Leu Tyr Lys His Asp Ser Asn
                485                 490                 495     
Glu Phe Ala Val Gly Thr Lys Asn Tyr Ser Val Ser Ala Gly Asp Pro
            500                 505                 510         
Pro Val Thr Ala Met Ser Ser Val Glu Thr Pro Gln Ile Ser Pro Ala
        515                 520                 525             
Met Ala Lys Lys Ile Asn Gln Asp Ile Lys Cys Gln Leu Met Lys Glu
    530                 535                 540                 
Val Gln Arg Phe Gly Gln Asn Tyr Lys Arg Ile Phe Ile Leu Leu Glu
545                 550                 555                 560 
Glu Leu Gln Gly Ser Met Lys Val Lys Arg Gln Phe Val Glu Phe Thr
                565                 570                 575     
Ile Arg Glu Ala Leu Asn Phe Phe Asn Trp Phe Pro Asp Ala Thr Val
            580                 585                 590         
Asn Pro Asn Val His Glu Glu Gln Met Glu Asn Gly Gln Thr Gln Pro
        595                 600                 605             
His Asn Ile Leu Ser His Val Leu Ser Gly Leu Ile Asn Met Ala Gly
    610                 615                 620                 
Ala Gly Ile Pro Leu Met Ser Thr Arg His Leu Tyr Ala Thr Ile Thr
625                 630                 635                 640 
His Asn Val Gly Glu Glu Arg Met Glu Asn Ser Gln Pro Gln Thr Asp
                645                 650                 655     
Asn Val Leu Ser Thr Ile Pro Pro Gln Val Arg His Met Ala Ala Ala
            660                 665                 670         
Gly Ile Pro Ser Met Ser Thr Ile Tyr Gln Cys Met Phe Val His Gln
        675                 680                 685             
Leu Tyr Cys Pro Thr Trp Phe Pro Tyr Ala Cys Ser Val Met Gln Gly
    690                 695                 700                 
Arg Arg Cys Tyr Arg His Ser Gln Cys Pro Gln Arg Glu Asn Gly Lys
705                 710                 715                 720 
Trp Pro Thr Pro Thr Asp His Asp Leu Ser Thr Gly Leu Thr Ala Leu
                725                 730                 735     
Ile Asn Met Ala Ala Ala Asp Ile Pro Ala Met Ser Thr Arg Asp Leu
            740                 745                 750         
Tyr Ala Thr Val Thr His Asn Val Tyr Glu Gln Lys Ile Glu Asn Gly
        755                 760                 765             
Gln Pro Ala Pro Asp Asn Val Leu Leu Thr Leu Pro Pro Glu Leu Ile
    770                 775                 780                 
Asn Met Thr Ala Thr Asp Ile Ser Ser Met Asn Ala Thr Ile Thr Tyr
785                 790                 795                 800 
Tyr Val Pro Glu Glu Lys Met Glu Asp Gly Gln Pro Gln Ser Asp Asn
                805                 810                 815     
Val Phe Ser Thr Ala Pro Thr Gly Leu Asn Met Thr Gly Ala Asp Ile
            820                 825                 830         
Pro Ala Met Ser Thr Asn Asp Leu Tyr Ala Thr Val Thr His Asn Val
        835                 840                 845             
Cys Glu Glu Arg Met Glu Asn Asn Arg Pro Gln Pro Asn Asn Val Arg
    850                 855                 860                 
Ser Thr Leu Pro Leu Arg Leu Ser Tyr Leu Ala Thr Ala Gly Ile Pro
865                 870                 875                 880 
Ala Met Ser Thr Arg Asp Gln Tyr Ala Thr Val Thr His Asn Val His
                885                 890                 895     
Glu Glu Lys Thr Lys Asn Gly Gln Pro Ala Pro Asp Asn Val Ile Ala
            900                 905                 910         
Thr Val Pro Pro Ala Leu Thr Asn Met Ala Ala Ala Gly Val Ser Ser
        915                 920                 925             
Met Ser Thr Arg Asp Gln Tyr Ala Thr Phe Thr His Asn Val His Glu
    930                 935                 940                 
Glu Lys Met Glu Asn Gly Gln Pro Ala Pro Gln Asn Ile Leu Ser Asn
945                 950                 955                 960 
Val Leu Pro Gly Leu Ile Asn Met Glu Ala Thr Gly Ile Pro Ser Met
                965                 970                 975     
Ser Thr Arg Asp Leu Tyr Ala Thr Ile Thr His Asp Val His Glu Glu
            980                 985                 990         
Glu Met Glu Asn Trp Gln Cys Gln Leu Asp Asn Val Phe Ser Thr Ala
        995                 1000                1005            
Ala Pro
    1010


<210> 8171
<211> 979
<212> PRT
<213> Homo sapiens

<400> 8171
Met Val Phe Phe Ser Ser Gln Tyr Arg Leu His Arg Lys Ser Gln Tyr
 1               5                  10                  15      
Leu Lys Met Ala Ala Ala Asn Leu Thr Phe Ser Gln Glu Val Val Trp
            20                  25                  30          
Gln Arg Gly Leu Pro Ser Ile Pro Tyr Ser Gln Tyr Ser Phe Asp His
        35                  40                  45              
Leu Tyr Asn Thr Asn Asp Ile Ile His Thr Pro Gln Ile Arg Lys Ala
    50                  55                  60                  
Arg Pro Gln Lys Pro Val Ser Phe Lys Phe Leu Gly Ser Ser Ser Pro
65                  70                  75                  80  
Leu Thr Gly Asp Thr Ser Leu Ala Val Lys Thr Glu Ser Ser Ala Asn
                85                  90                  95      
Pro Glu Lys Lys Leu Lys Lys Ser Lys Pro Ala Ser Thr Val Arg Glu
            100                 105                 110         
Ala Pro Arg Pro Leu Ile His His Pro Cys Met His Pro Asp Met Leu
        115                 120                 125             
Gly Arg Pro Pro Ser Leu Asp Val Asn Leu Glu Glu Arg Glu Ala Trp
    130                 135                 140                 
Leu Leu Pro Pro Glu Lys Glu Ala Arg Ala Trp Glu Ala Thr Val Leu
145                 150                 155                 160 
Glu Lys Leu Asn Glu Arg Thr Ala Arg Trp Ile Gln Ser Lys Arg Pro
                165                 170                 175     
Arg Arg Pro Gly Ala Ser Pro Asn Lys Trp Gln Ser Phe Leu Arg Gln
            180                 185                 190         
Gln Tyr Asp Trp Ser His Ile Arg Asp Glu Leu Thr Ser Ala Ser Asp
        195                 200                 205             
Leu Glu Leu Leu Lys Gln Leu Glu Ala Glu Glu Thr Ala Glu Phe Glu
    210                 215                 220                 
Asp Gln Ser Val Ile Leu Pro Pro Gln Glu Lys Lys Lys Pro Glu Leu
225                 230                 235                 240 
Leu Leu Pro Val Tyr Tyr Arg Leu Pro Ser Tyr Phe Gln Gln Ala Glu
                245                 250                 255     
Thr Val Glu Ile Met Pro Gly Asn Lys Ser Thr Glu Asp Ile His Glu
            260                 265                 270         
Lys Thr Ser Leu Ser Gln Pro Gln Thr Gln Ser Tyr Phe Arg Gln Val
        275                 280                 285             
Thr Pro Arg Ala Gly Lys Phe Ala Tyr Ser Thr Asp Asn Thr Phe Glu
    290                 295                 300                 
Gln Glu Ile Tyr Phe Asp Glu Val Gln Ile Ile His Gln Ile Gly Ala
305                 310                 315                 320 
Lys Arg Asp Gln Ile Val Leu Glu Asn Leu Asn Arg Tyr Asn Lys Gln
                325                 330                 335     
Leu Ser Lys Val Phe Pro Glu Thr Pro Glu Lys Trp Ser Ala Gln Ala
            340                 345                 350         
Ile Pro Glu Ala Ser Tyr Arg Pro Val Gln Gly Ala Leu Arg Trp Thr
        355                 360                 365             
Ala Leu Pro Thr Pro Ala Lys Asp Met Leu Leu Gln Val Gly Glu Lys
    370                 375                 380                 
Asp Val Pro Ile Lys Thr Arg Arg Leu Lys Lys Gln Ala Lys Ser Leu
385                 390                 395                 400 
Gln Glu Asp Val Thr Trp Glu Leu Val Val Leu Arg Arg Met Leu Lys
                405                 410                 415     
Glu Trp Lys Thr Ala Trp Ala Leu Ile Ile Glu Trp His His Glu Thr
            420                 425                 430         
Val Glu Asn Leu Leu Gln Ser Leu Gly Asp Leu His Asp Asp Val Arg
        435                 440                 445             
Ile Lys Ala Ile Thr Thr Cys Ala Thr Ala Ala Leu Glu Arg Pro Arg
    450                 455                 460                 
Ile Ala Thr Ser Gln Arg Asp Ser Asp Lys Thr Ile Gln Asp Leu Pro
465                 470                 475                 480 
Glu Val Leu Leu Pro Ala Leu Glu Ala Ala Leu Cys Asp Lys Asn Ala
                485                 490                 495     
His Val Arg Met Ala Ala Ala Ile Cys Gln Tyr Ala Ile Gln Ser His
            500                 505                 510         
Asn Pro Leu Ala Arg Asn Ile Met Gln Thr Ala Leu Leu Lys Gly Asn
        515                 520                 525             
Ser Val Asp Ser Trp Ala Ala Ala Gln Cys Leu Ala Leu Glu Gly Thr
    530                 535                 540                 
Ala Thr Tyr Pro Val Ile Lys Arg Ile Leu His Gln Leu Phe Thr Lys
545                 550                 555                 560 
Lys Asn Glu Asp Thr Glu Glu Gln Ser Tyr Ile Leu Leu Ser Tyr Leu
                565                 570                 575     
Ser Glu Lys Thr Thr Leu Ile His Thr Met Leu Ala Val Glu Leu Asn
            580                 585                 590         
Ser Cys Gln Trp Lys Asn Arg Ile Val Ala Cys Gln Ala Phe Ser Arg
        595                 600                 605             
Ile Ser Gly Asn Val Cys Leu Asp Met Lys His Lys Leu Ile Gln Leu
    610                 615                 620                 
Met Trp Asn Asp Trp Asn Lys Glu Val Arg Arg Ala Ala Ala Gln Ala
625                 630                 635                 640 
Leu Gly Gln Met Ser Leu Gly Lys Glu Val His Asp Ile Ile Arg Val
                645                 650                 655     
Lys Leu Gly Gln Gly Asn Ser Gln Glu Arg Val Glu Ala Leu Tyr Leu
            660                 665                 670         
Ile Gly Glu Leu Lys Leu Met Thr Ala Lys Leu Leu Pro Ser Phe Leu
        675                 680                 685             
His Cys Phe Ser Asp Asp Phe Thr Ala Val Arg Arg Ala Ala Cys Leu
    690                 695                 700                 
Ala Ala Gly Ala Leu Gln Ile Arg Asp Lys Met Val Leu Glu Cys Leu
705                 710                 715                 720 
Leu Asn Leu Met Gln Arg Asp Pro Tyr Trp Lys Ile Lys Ala Phe Ala
                725                 730                 735     
Ile Arg Ala Leu Gly Gln Ile Gly Gln Val Ser Pro Glu Leu Thr Asp
            740                 745                 750         
Leu Leu Leu Trp Ala Ile His Tyr Glu Glu Ser Pro Gly Val Arg Leu
        755                 760                 765             
Glu Ala Cys Arg Ser Ile Leu Ala Leu Lys Leu Gln Gly Asp Arg Val
    770                 775                 780                 
Arg Asp Thr Phe Leu Asp Val Leu Leu Leu Glu Asn His Asp Ala Val
785                 790                 795                 800 
Leu Lys Glu Met Tyr Gln Thr Met Lys Ile Leu Asn Leu Gly Asn Glu
                805                 810                 815     
Gly Asn Gln Glu Met Leu Gln Glu Ile Lys Asn Arg Ile Lys Thr Leu
            820                 825                 830         
Ser Gln Lys Asp Leu Leu Thr His Lys Ile Leu Lys Leu Glu Met Val
        835                 840                 845             
Met Gly Lys Val Arg Glu Glu Ala Lys Arg Val Tyr Leu Lys Pro Lys
    850                 855                 860                 
Gly Glu Gln Gly Pro Leu Thr Leu Gln Thr Leu Leu Gln Glu Thr Phe
865                 870                 875                 880 
Gln Asp Glu Met Val Leu Pro Arg Arg Pro Ser Glu Val Cys Asp Thr
                885                 890                 895     
Glu Ala Val Ile Lys Pro Val Lys Pro Arg Ala Pro Asn Pro Trp Leu
            900                 905                 910         
Gln Ser Ser Val Pro Gly Leu Thr Thr Arg Ser Lys Val Arg Ser Ser
        915                 920                 925             
Leu Val Lys Asp Leu Arg Thr Ser Pro Glu Lys Arg Ile Ala Val Gly
    930                 935                 940                 
Pro Phe Arg Ser Asp Tyr Pro Ala Leu Tyr Leu Gly Lys Phe Ser Glu
945                 950                 955                 960 
Arg Thr Phe Phe Ser Pro Ile Met Ser Ser Pro Ser Gly Lys Lys Gly
                965                 970                 975     
Ala His Leu
            


<210> 8172
<211> 232
<212> PRT
<213> Homo sapiens

<400> 8172
Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys His Ile Asn Lys Pro
 1               5                  10                  15      
Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln
            20                  25                  30          
Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Pro Asp Tyr Ile His
        35                  40                  45              
Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu
    50                  55                  60                  
Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr
65                  70                  75                  80  
Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Arg Ala Pro
                85                  90                  95      
Ala Glu Lys Leu Val Gly Phe Pro Ala Tyr Gly His Ser Phe Leu Leu
            100                 105                 110         
Ser Asn Pro Ser Asn His Gly Ile Asp Ala Pro Thr Thr Gly Pro Gly
        115                 120                 125             
Pro Ala Gly Pro Tyr Thr Arg Gln Ser Gly Phe Trp Ala Tyr Tyr Glu
    130                 135                 140                 
Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Glu Val Trp Glu Ala Ser
145                 150                 155                 160 
Glu Asp Val Pro Tyr Ala Tyr Lys Gly Asn Glu Trp Leu Gly Tyr Asp
                165                 170                 175     
Asn Thr Lys Ser Phe Gln Ile Lys Val Asp Tyr Trp Leu Lys Lys Asn
            180                 185                 190         
Asn Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr
        195                 200                 205             
Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Thr Thr Leu Lys
    210                 215                 220                 
Asp Ala Leu Gly Leu Gln Ser Thr
225                 230         


<210> 8173
<211> 2265
<212> PRT
<213> Homo sapiens

<400> 8173
Met Val Ser Ile Asp Leu His Gln Ala Gly Arg Val Asp Ser Gln Ala
 1               5                  10                  15      
Ser Ile Thr Gln Asp Ser Asp Ser Ile Lys Lys Pro Glu Glu Ile Lys
            20                  25                  30          
Gln Cys Asn Asp Ala Pro Val Ser Val Leu Gln Glu Asp Ile Val Gly
        35                  40                  45              
Ser Leu Lys Ser Thr Pro Glu Asn His Pro Glu Thr Pro Lys Lys Lys
    50                  55                  60                  
Ser Asp Pro Glu Leu Ser Lys Ser Glu Met Lys Gln Ser Glu Ser Arg
65                  70                  75                  80  
Leu Ala Glu Ser Lys Pro Asn Glu Asn Arg Leu Val Glu Thr Lys Ser
                85                  90                  95      
Ser Glu Asn Lys Leu Glu Thr Lys Val Glu Thr Gln Thr Glu Glu Leu
            100                 105                 110         
Lys Gln Asn Glu Ser Arg Thr Thr Glu Cys Lys Gln Asn Glu Ser Thr
        115                 120                 125             
Ile Val Glu Pro Lys Gln Asn Glu Asn Arg Leu Ser Asp Thr Lys Pro
    130                 135                 140                 
Asn Asp Asn Lys Gln Asn Asn Gly Arg Ser Glu Thr Thr Lys Ser Arg
145                 150                 155                 160 
Pro Glu Thr Pro Lys Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro Lys
                165                 170                 175     
Gln Lys Ser Asp Gly His Pro Glu Thr Pro Lys Gln Lys Gly Asp Gly
            180                 185                 190         
Arg Pro Glu Thr Pro Lys Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro
        195                 200                 205             
Lys Gln Lys Asn Glu Gly Arg Pro Glu Thr Pro Lys His Arg His Asp
    210                 215                 220                 
Asn Arg Arg Asp Ser Gly Lys Pro Ser Thr Glu Lys Lys Pro Glu Val
225                 230                 235                 240 
Ser Lys His Lys Gln Asp Thr Lys Ser Asp Ser Pro Arg Leu Lys Ser
                245                 250                 255     
Glu Arg Ala Glu Ala Leu Lys Gln Arg Pro Asp Gly Arg Ser Val Ser
            260                 265                 270         
Glu Ser Leu Arg Arg Asp His Asp Asn Lys Gln Lys Ser Asp Asp Arg
        275                 280                 285             
Gly Glu Ser Glu Arg His Arg Gly Asp Gln Ser Arg Val Arg Arg Pro
    290                 295                 300                 
Glu Thr Leu Arg Ser Ser Ser Arg Asn Glu His Gly Ile Lys Ser Asp
305                 310                 315                 320 
Ser Ser Lys Thr Asp Lys Leu Glu Arg Lys His Arg His Glu Ser Gly
                325                 330                 335     
Asp Ser Arg Glu Arg Pro Ser Ser Gly Glu Gln Lys Ser Arg Pro Asp
            340                 345                 350         
Ser Pro Arg Val Lys Gln Gly Asp Ser Asn Lys Ser Arg Ser Asp Lys
        355                 360                 365             
Leu Gly Phe Lys Ser Pro Thr Ser Lys Asp Asp Lys Arg Thr Glu Gly
    370                 375                 380                 
Asn Lys Ser Lys Val Asp Thr Asn Lys Ala His Pro Asp Asn Lys Ala
385                 390                 395                 400 
Glu Phe Pro Ser Tyr Leu Leu Gly Gly Arg Ser Gly Ala Leu Lys Asn
                405                 410                 415     
Phe Val Ile Pro Lys Ile Lys Arg Asp Lys Asp Gly Asn Val Thr Gln
            420                 425                 430         
Glu Thr Lys Lys Met Glu Met Lys Gly Glu Pro Lys Asp Lys Val Glu
        435                 440                 445             
Lys Ile Gly Leu Val Glu Asp Leu Asn Lys Gly Ala Lys Pro Val Val
    450                 455                 460                 
Val Leu Gln Lys Leu Ser Leu Asp Asp Val Gln Lys Leu Ile Lys Asp
465                 470                 475                 480 
Arg Glu Asp Lys Ser Arg Ser Ser Leu Lys Pro Ile Lys Asn Lys Pro
                485                 490                 495     
Ser Lys Ser Asn Lys Gly Ser Ile Asp Gln Ser Val Leu Lys Glu Leu
            500                 505                 510         
Pro Pro Glu Leu Leu Ala Glu Ile Glu Ser Thr Met Pro Leu Cys Glu
        515                 520                 525             
Arg Val Lys Met Asn Lys Arg Lys Arg Ser Thr Val Asn Glu Lys Pro
    530                 535                 540                 
Lys Tyr Ala Glu Ile Ser Ser Asp Glu Asp Asn Asp Ser Asp Glu Ala
545                 550                 555                 560 
Phe Glu Ser Ser Arg Lys Arg His Lys Lys Asp Asp Asp Lys Ala Trp
                565                 570                 575     
Glu Tyr Glu Glu Arg Asp Arg Arg Ser Ser Gly Asp His Arg Arg Ser
            580                 585                 590         
Gly His Ser His Glu Gly Arg Arg Ser Ser Gly Gly Gly Arg Tyr Arg
        595                 600                 605             
Asn Arg Ser Pro Ser Asp Ser Asp Met Glu Asp Tyr Ser Pro Pro Pro
    610                 615                 620                 
Ser Leu Ser Glu Val Ala Arg Lys Met Lys Lys Lys Glu Lys Gln Lys
625                 630                 635                 640 
Lys Arg Lys Ala Tyr Glu Pro Lys Leu Thr Pro Glu Glu Met Met Asp
                645                 650                 655     
Ser Ser Thr Phe Lys Arg Phe Thr Ala Ser Ile Glu Asn Ile Leu Asp
            660                 665                 670         
Asn Leu Glu Asp Met Asp Phe Thr Ala Phe Gly Asp Asp Asp Glu Ile
        675                 680                 685             
Pro Gln Glu Leu Leu Leu Gly Lys His Gln Leu Asn Glu Leu Gly Ser
    690                 695                 700                 
Glu Ser Ala Lys Ile Lys Ala Met Gly Ile Met Asp Lys Leu Ser Thr
705                 710                 715                 720 
Asp Lys Thr Val Lys Val Leu Asn Ile Leu Glu Lys Asn Ile Gln Asp
                725                 730                 735     
Gly Ser Lys Leu Ser Thr Leu Leu Asn His Asn Asn Asp Thr Glu Glu
            740                 745                 750         
Glu Glu Arg Leu Trp Arg Asp Leu Ile Met Glu Arg Val Thr Lys Ser
        755                 760                 765             
Ala Asp Ala Cys Leu Thr Thr Ile Asn Ile Met Thr Ser Pro Asn Met
    770                 775                 780                 
Pro Lys Ala Val Tyr Ile Glu Asp Val Ile Glu Arg Val Ile Gln Tyr
785                 790                 795                 800 
Thr Lys Phe His Leu Gln Asn Thr Leu Tyr Pro Gln Tyr Asp Pro Val
                805                 810                 815     
Tyr Arg Leu Asp Pro His Gly Gly Gly Leu Leu Ser Ser Lys Ala Lys
            820                 825                 830         
Arg Ala Lys Cys Ser Thr His Lys Gln Arg Val Ile Val Met Leu Tyr
        835                 840                 845             
Asn Lys Val Cys Asp Ile Val Ser Ser Leu Ser Glu Leu Leu Glu Ile
    850                 855                 860                 
Gln Leu Leu Thr Asp Thr Thr Ile Leu Gln Val Ser Ser Met Gly Ile
865                 870                 875                 880 
Thr Pro Phe Phe Val Glu Asn Val Ser Glu Leu Gln Leu Cys Ala Ile
                885                 890                 895     
Lys Leu Val Thr Ala Val Phe Ser Arg Tyr Glu Lys His Arg Gln Leu
            900                 905                 910         
Ile Leu Glu Glu Ile Phe Thr Ser Leu Ala Arg Leu Pro Thr Ser Lys
        915                 920                 925             
Arg Ser Leu Arg Asn Phe Arg Leu Asn Ser Ser Asp Met Asp Gly Glu
    930                 935                 940                 
Pro Met Tyr Ile Gln Met Val Thr Ala Leu Val Leu Gln Leu Ile Gln
945                 950                 955                 960 
Cys Val Val His Leu Pro Ser Ser Glu Lys Asp Ser Asn Ala Glu Glu
                965                 970                 975     
Asp Ser Asn Lys Lys Ile Asp Gln Asp Val Val Ile Thr Asn Ser Tyr
            980                 985                 990         
Glu Thr Ala Met Arg Thr Ala Gln Asn Phe Leu Ser Ile Phe Leu Lys
        995                 1000                1005            
Lys Cys Gly Ser Lys Gln Gly Glu Glu Asp Tyr Arg Pro Leu Phe Glu
    1010                1015                1020                
Asn Phe Val Gln Asp Leu Leu Ser Thr Val Asn Lys Pro Glu Trp Pro
1025                1030                1035                1040
Ala Ala Glu Leu Leu Leu Ser Leu Leu Gly Arg Leu Leu Val His Gln
                1045                1050                1055    
Phe Ser Asn Lys Ser Thr Glu Met Ala Leu Arg Val Ala Ser Leu Asp
            1060                1065                1070        
Tyr Leu Gly Thr Val Ala Ala Arg Leu Arg Lys Asp Ala Val Thr Ser
        1075                1080                1085            
Lys Met Asp Gln Gly Ser Ile Glu Arg Ile Leu Lys Gln Val Ser Gly
    1090                1095                1100                
Gly Glu Asp Glu Ile Gln Gln Leu Gln Lys Ala Leu Leu Asp Tyr Leu
1105                1110                1115                1120
Asp Glu Asn Thr Glu Thr Asp Pro Ser Leu Val Phe Ser Arg Lys Phe
                1125                1130                1135    
Tyr Ile Ala Gln Trp Phe Arg Asp Thr Thr Leu Glu Thr Glu Lys Ala
            1140                1145                1150        
Met Lys Ser Gln Lys Asp Glu Glu Ser Ser Glu Gly Thr His His Ala
        1155                1160                1165            
Lys Glu Ile Glu Thr Thr Gly Gln Ile Met His Arg Ala Glu Asn Arg
    1170                1175                1180                
Lys Lys Phe Leu Arg Ser Ile Ile Lys Thr Thr Pro Ser Gln Phe Ser
1185                1190                1195                1200
Thr Leu Lys Met Asn Ser Asp Thr Val Asp Tyr Asp Asp Ala Cys Leu
                1205                1210                1215    
Ile Val Arg Tyr Leu Ala Ser Met Arg Pro Phe Ala Gln Ser Phe Asp
            1220                1225                1230        
Ile Tyr Leu Thr Gln Ile Leu Arg Val Leu Gly Glu Asn Ala Ile Ala
        1235                1240                1245            
Val Arg Thr Lys Ala Met Lys Cys Leu Ser Glu Val Val Ala Val Asp
    1250                1255                1260                
Pro Ser Ile Leu Ala Arg Leu Asp Met Gln Arg Gly Val His Gly Arg
1265                1270                1275                1280
Leu Met Asp Asn Ser Thr Ser Val Arg Glu Ala Ala Val Glu Leu Leu
                1285                1290                1295    
Gly Arg Phe Val Leu Cys Arg Pro Gln Leu Ala Glu Gln Tyr Tyr Asp
            1300                1305                1310        
Met Leu Ile Glu Arg Ile Leu Asp Thr Gly Ile Ser Val Arg Lys Arg
        1315                1320                1325            
Val Ile Lys Ile Leu Arg Asp Ile Cys Ile Glu Gln Pro Thr Phe Pro
    1330                1335                1340                
Lys Ile Thr Glu Met Cys Val Lys Met Ile Arg Arg Val Asn Asp Glu
1345                1350                1355                1360
Glu Gly Ile Lys Lys Leu Val Asn Glu Thr Phe Gln Lys Leu Trp Phe
                1365                1370                1375    
Thr Pro Thr Pro His Asn Asp Lys Glu Ala Met Thr Arg Lys Ile Leu
            1380                1385                1390        
Asn Ile Thr Asp Val Val Ala Ala Cys Arg Asp Thr Gly Tyr Asp Trp
        1395                1400                1405            
Phe Glu Gln Leu Leu Gln Asn Leu Leu Lys Ser Glu Glu Asp Ser Ser
    1410                1415                1420                
Tyr Lys Pro Val Lys Lys Ala Cys Thr Gln Leu Val Asp Asn Leu Val
1425                1430                1435                1440
Glu His Ile Leu Lys Tyr Glu Glu Ser Leu Ala Asp Ser Asp Asn Lys
                1445                1450                1455    
Gly Val Asn Ser Gly Arg Leu Val Ala Cys Ile Thr Thr Leu Phe Leu
            1460                1465                1470        
Phe Ser Lys Ile Arg Pro Gln Leu Met Val Lys His Ala Met Thr Met
        1475                1480                1485            
Gln Pro Tyr Leu Thr Thr Lys Cys Ser Thr Gln Asn Asp Phe Met Val
    1490                1495                1500                
Ile Cys Asn Val Ala Lys Ile Leu Glu Leu Val Val Pro Leu Met Glu
1505                1510                1515                1520
His Pro Ser Glu Thr Phe Leu Ala Thr Ile Glu Glu Asp Leu Met Lys
                1525                1530                1535    
Leu Ile Ile Lys Tyr Gly Met Thr Val Val Gln His Cys Val Ser Cys
            1540                1545                1550        
Leu Gly Ala Val Val Asn Lys Val Thr Gln Asn Phe Lys Phe Val Trp
        1555                1560                1565            
Ala Cys Phe Asn Arg Tyr Tyr Gly Ala Ile Ser Lys Leu Lys Ser Gln
    1570                1575                1580                
His Gln Glu Asp Pro Asn Asn Thr Ser Leu Leu Thr Asn Lys Pro Ala
1585                1590                1595                1600
Leu Leu Arg Ser Leu Phe Thr Val Gly Ala Leu Cys Arg His Phe Asp
                1605                1610                1615    
Phe Asp Leu Glu Asp Phe Lys Gly Asn Ser Lys Val Asn Ile Lys Asp
            1620                1625                1630        
Lys Val Leu Glu Leu Leu Met Tyr Phe Thr Lys His Ser Asp Glu Glu
        1635                1640                1645            
Val Gln Thr Lys Ala Ile Ile Gly Leu Gly Phe Ala Phe Ile Gln His
    1650                1655                1660                
Pro Ser Leu Met Phe Glu Gln Glu Val Lys Asn Leu Tyr Asn Asn Ile
1665                1670                1675                1680
Leu Ser Asp Lys Asn Ser Ser Val Asn Leu Lys Ile Gln Val Leu Lys
                1685                1690                1695    
Asn Leu Gln Thr Tyr Leu Gln Glu Glu Asp Thr Arg Met Gln Gln Ala
            1700                1705                1710        
Asp Arg Asp Trp Lys Lys Val Ala Lys Gln Glu Asp Leu Lys Glu Met
        1715                1720                1725            
Gly Asp Val Ser Ser Gly Met Ser Ser Ser Ile Met Gln Leu Tyr Leu
    1730                1735                1740                
Lys Gln Val Leu Glu Ala Phe Phe His Thr Gln Ser Ser Val Arg His
1745                1750                1755                1760
Phe Ala Leu Asn Val Ile Ala Leu Thr Leu Asn Gln Gly Leu Ile His
                1765                1770                1775    
Pro Val Gln Cys Val Pro Tyr Leu Ile Ala Met Gly Thr Asp Pro Glu
            1780                1785                1790        
Pro Ala Met Arg Asn Lys Ala Asp Gln Gln Leu Val Glu Ile Asp Lys
        1795                1800                1805            
Lys Tyr Ala Gly Phe Ile His Met Lys Ala Val Ala Gly Met Lys Met
    1810                1815                1820                
Ser Tyr Gln Val Gln Gln Ala Ile Asn Thr Cys Leu Lys Asp Pro Val
1825                1830                1835                1840
Arg Gly Phe Arg Gln Asp Glu Ser Ser Ser Ala Leu Cys Ser His Leu
                1845                1850                1855    
Tyr Ser Met Ile Arg Gly Asn Arg Gln His Arg Arg Ala Phe Leu Ile
            1860                1865                1870        
Ser Leu Leu Asn Leu Phe Asp Asp Thr Ala Lys Thr Asp Val Thr Met
        1875                1880                1885            
Leu Leu Tyr Ile Ala Asp Asn Leu Ala Cys Phe Pro Tyr Gln Thr Gln
    1890                1895                1900                
Glu Glu Pro Leu Phe Ile Met His His Ile Asp Ile Thr Leu Ser Val
1905                1910                1915                1920
Ser Gly Ser Asn Leu Leu Gln Ser Phe Lys Glu Ser Met Val Lys Asp
                1925                1930                1935    
Lys Arg Lys Glu Arg Lys Ser Ser Pro Ser Lys Glu Asn Glu Ser Ser
            1940                1945                1950        
Asp Ser Glu Glu Glu Val Ser Arg Pro Arg Lys Ser Arg Lys Arg Val
        1955                1960                1965            
Asp Ser Asp Ser Asp Ser Asp Ser Glu Asp Asp Ile Asn Ser Val Met
    1970                1975                1980                
Lys Cys Leu Pro Glu Asn Ser Ala Pro Leu Ile Glu Phe Ala Asn Val
1985                1990                1995                2000
Ser Gln Gly Ile Leu Leu Leu Leu Met Leu Lys Gln His Leu Lys Asn
                2005                2010                2015    
Leu Cys Gly Phe Ser Asp Ser Lys Ile Gln Lys Tyr Ser Pro Ser Glu
            2020                2025                2030        
Ser Ala Lys Val Tyr Asp Lys Ala Ile Asn Arg Lys Thr Gly Val His
        2035                2040                2045            
Phe His Pro Lys Gln Thr Leu Asp Phe Leu Arg Ser Asp Met Ala Asn
    2050                2055                2060                
Ser Lys Ile Thr Glu Glu Val Lys Arg Ser Ile Val Lys Gln Tyr Leu
2065                2070                2075                2080
Asp Phe Lys Leu Leu Met Glu His Leu Asp Pro Asp Glu Glu Glu Glu
                2085                2090                2095    
Glu Gly Glu Val Ser Ala Ser Thr Asn Ala Arg Asn Lys Ala Ile Thr
            2100                2105                2110        
Ser Leu Leu Gly Gly Gly Ser Pro Lys Asn Asn Thr Ala Ala Glu Thr
        2115                2120                2125            
Glu Asp Asp Glu Ser Asp Gly Glu Asp Arg Gly Gly Gly Thr Ser Gly
    2130                2135                2140                
Ser Leu Arg Arg Ser Lys Arg Asn Ser Asp Ser Thr Glu Leu Ala Ala
2145                2150                2155                2160
Gln Met Asn Glu Ser Val Asp Val Met Asp Val Ile Ala Ile Cys Cys
                2165                2170                2175    
Pro Lys Tyr Lys Asp Arg Pro Gln Ile Ala Arg Val Val Gln Lys Thr
            2180                2185                2190        
Ser Ser Gly Phe Ser Val Gln Trp Met Ala Gly Ser Tyr Ser Gly Ser
        2195                2200                2205            
Trp Thr Glu Ala Lys Arg Arg Asp Gly Arg Lys Leu Val Pro Trp Val
    2210                2215                2220                
Asp Thr Ile Lys Glu Ser Asp Ile Ile Tyr Lys Lys Ile Ala Leu Thr
2225                2230                2235                2240
Ser Ala Asn Lys Leu Thr Asn Lys Val Val Gln Thr Leu Arg Ser Leu
                2245                2250                2255    
Tyr Ala Ala Lys Asp Gly Thr Ser Ser
            2260                2265


<210> 8174
<211> 2158
<212> PRT
<213> Homo sapiens

<400> 8174
Met Val Ser Ile Asp Leu His Gln Ala Gly Arg Val Asp Ser Gln Ala
 1               5                  10                  15      
Ser Ile Thr Gln Asp Ser Asp Ser Ile Lys Lys Pro Glu Glu Ile Lys
            20                  25                  30          
Gln Cys Asn Asp Ala Pro Val Ser Val Leu Gln Glu Asp Ile Val Gly
        35                  40                  45              
Ser Leu Lys Ser Thr Pro Glu Asn His Pro Glu Thr Pro Lys Lys Lys
    50                  55                  60                  
Ser Asp Pro Glu Leu Ser Lys Ser Glu Met Lys Gln Ser Glu Ser Arg
65                  70                  75                  80  
Leu Ala Glu Ser Lys Pro Asn Glu Asn Arg Leu Val Glu Thr Lys Ser
                85                  90                  95      
Ser Glu Asn Lys Leu Glu Thr Lys Val Glu Thr Gln Thr Glu Glu Leu
            100                 105                 110         
Lys Gln Asn Glu Ser Arg Thr Thr Glu Cys Lys Gln Asn Glu Ser Thr
        115                 120                 125             
Ile Val Glu Pro Lys Gln Asn Glu Asn Arg Leu Ser Asp Thr Lys Pro
    130                 135                 140                 
Asn Asp Asn Lys Gln Asn Asn Gly Arg Ser Glu Thr Thr Lys Ser Arg
145                 150                 155                 160 
Pro Glu Thr Pro Lys Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro Lys
                165                 170                 175     
Gln Lys Ser Asp Gly His Pro Glu Thr Pro Lys Gln Lys Gly Asp Gly
            180                 185                 190         
Arg Pro Glu Thr Pro Lys Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro
        195                 200                 205             
Lys Gln Lys Asn Glu Gly Arg Pro Glu Thr Pro Lys His Arg His Asp
    210                 215                 220                 
Asn Arg Arg Asp Ser Gly Lys Pro Ser Thr Glu Lys Lys Pro Glu Val
225                 230                 235                 240 
Ser Lys His Lys Gln Asp Thr Lys Ser Asp Ser Pro Arg Leu Lys Ser
                245                 250                 255     
Glu Arg Ala Glu Ala Leu Lys Gln Arg Pro Asp Gly Arg Ser Val Ser
            260                 265                 270         
Glu Ser Leu Arg Arg Asp His Asp Asn Lys Gln Lys Ser Asp Asp Arg
        275                 280                 285             
Gly Glu Ser Glu Arg His Arg Gly Asp Gln Ser Arg Val Arg Arg Pro
    290                 295                 300                 
Glu Thr Leu Arg Ser Ser Ser Arg Asn Glu His Gly Ile Lys Ser Asp
305                 310                 315                 320 
Ser Ser Lys Thr Asp Lys Leu Glu Arg Lys His Arg His Glu Ser Gly
                325                 330                 335     
Asp Ser Arg Glu Arg Pro Ser Ser Gly Glu Gln Lys Ser Arg Pro Asp
            340                 345                 350         
Ser Pro Arg Val Lys Gln Gly Asp Ser Asn Lys Ser Arg Ser Asp Lys
        355                 360                 365             
Leu Gly Phe Lys Ser Pro Thr Ser Lys Asp Asp Lys Arg Thr Glu Gly
    370                 375                 380                 
Asn Lys Ser Lys Val Asp Thr Asn Lys Ala His Pro Asp Asn Lys Ala
385                 390                 395                 400 
Glu Phe Pro Ser Tyr Leu Leu Gly Gly Arg Ser Gly Ala Leu Lys Asn
                405                 410                 415     
Phe Val Ile Pro Lys Ile Lys Arg Asp Lys Asp Gly Asn Val Thr Gln
            420                 425                 430         
Glu Thr Lys Lys Met Glu Met Lys Gly Glu Pro Lys Asp Lys Val Glu
        435                 440                 445             
Lys Ile Gly Leu Val Glu Asp Leu Asn Lys Gly Ala Lys Pro Val Val
    450                 455                 460                 
Val Leu Gln Lys Leu Ser Leu Asp Asp Val Gln Lys Leu Ile Lys Asp
465                 470                 475                 480 
Arg Glu Asp Lys Ser Arg Ser Ser Leu Lys Pro Ile Lys Asn Lys Pro
                485                 490                 495     
Ser Lys Ser Asn Lys Gly Ser Ile Asp Gln Ser Val Leu Lys Glu Leu
            500                 505                 510         
Pro Pro Glu Leu Leu Ala Glu Ile Glu Ser Thr Met Pro Leu Cys Glu
        515                 520                 525             
Arg Val Lys Met Asn Lys Arg Lys Arg Ser Thr Val Asn Glu Lys Pro
    530                 535                 540                 
Lys Tyr Ala Glu Ile Ser Ser Asp Glu Asp Asn Asp Ser Asp Glu Ala
545                 550                 555                 560 
Phe Glu Ser Ser Arg Lys Arg His Lys Lys Asp Asp Asp Lys Ala Trp
                565                 570                 575     
Glu Tyr Glu Glu Arg Asp Arg Arg Ser Ser Gly Asp His Arg Arg Ser
            580                 585                 590         
Gly His Ser His Glu Gly Arg Arg Ser Ser Gly Gly Gly Arg Tyr Arg
        595                 600                 605             
Asn Arg Ser Pro Ser Asp Ser Asp Met Glu Asp Tyr Ser Pro Pro Pro
    610                 615                 620                 
Ser Leu Ser Glu Val Ala Arg Lys Met Lys Lys Lys Glu Lys Gln Lys
625                 630                 635                 640 
Lys Arg Lys Ala Tyr Glu Pro Lys Leu Thr Pro Glu Glu Met Met Asp
                645                 650                 655     
Ser Ser Thr Phe Lys Arg Phe Thr Ala Ser Ile Glu Asn Ile Leu Asp
            660                 665                 670         
Asn Leu Glu Asp Met Asp Phe Thr Ala Phe Gly Asp Asp Asp Glu Ile
        675                 680                 685             
Pro Gln Glu Leu Leu Leu Gly Lys His Gln Leu Asn Glu Leu Gly Ser
    690                 695                 700                 
Glu Ser Ala Lys Ile Lys Ala Met Gly Ile Met Asp Lys Leu Ser Thr
705                 710                 715                 720 
Asp Lys Thr Val Lys Val Leu Asn Ile Leu Glu Lys Asn Ile Gln Asp
                725                 730                 735     
Gly Ser Lys Leu Ser Thr Leu Leu Asn His Asn Asn Asp Thr Glu Glu
            740                 745                 750         
Glu Glu Arg Leu Trp Arg Asp Leu Ile Met Glu Arg Val Thr Lys Ser
        755                 760                 765             
Ala Asp Ala Cys Leu Thr Thr Ile Asn Ile Met Thr Ser Pro Asn Met
    770                 775                 780                 
Pro Lys Ala Val Tyr Ile Glu Asp Val Ile Glu Arg Val Ile Gln Tyr
785                 790                 795                 800 
Thr Lys Phe His Leu Gln Asn Thr Leu Tyr Pro Gln Tyr Asp Pro Val
                805                 810                 815     
Tyr Arg Leu Asp Pro His Gly Gly Gly Leu Leu Ser Ser Lys Ala Lys
            820                 825                 830         
Arg Ala Lys Cys Ser Thr His Lys Gln Arg Val Ile Val Met Leu Tyr
        835                 840                 845             
Asn Lys Val Cys Asp Ile Val Ser Ser Leu Ser Glu Leu Leu Glu Ile
    850                 855                 860                 
Gln Leu Leu Thr Asp Thr Thr Ile Leu Gln Val Ser Ser Met Gly Ile
865                 870                 875                 880 
Thr Pro Phe Phe Val Glu Asn Val Ser Glu Leu Gln Leu Cys Ala Ile
                885                 890                 895     
Lys Leu Val Thr Ala Val Phe Ser Arg Tyr Glu Lys His Arg Gln Leu
            900                 905                 910         
Ile Leu Glu Glu Ile Phe Thr Ser Leu Ala Arg Leu Pro Thr Ser Lys
        915                 920                 925             
Arg Ser Leu Arg Asn Phe Arg Leu Asn Ser Ser Asp Met Asp Gly Glu
    930                 935                 940                 
Pro Met Tyr Ile Gln Met Val Thr Ala Leu Val Leu Gln Leu Ile Gln
945                 950                 955                 960 
Cys Val Val His Leu Pro Ser Ser Glu Lys Asp Ser Asn Ala Glu Glu
                965                 970                 975     
Asp Ser Asn Lys Lys Ile Asp Gln Asp Val Val Ile Thr Asn Ser Tyr
            980                 985                 990         
Glu Thr Ala Met Arg Thr Ala Gln Asn Phe Leu Ser Ile Phe Leu Lys
        995                 1000                1005            
Lys Cys Gly Ser Lys Gln Gly Glu Glu Asp Tyr Arg Pro Leu Phe Glu
    1010                1015                1020                
Asn Phe Val Gln Asp Leu Leu Ser Thr Val Asn Lys Pro Glu Trp Pro
1025                1030                1035                1040
Ala Ala Glu Leu Leu Leu Ser Leu Leu Gly Arg Leu Leu Val His Gln
                1045                1050                1055    
Phe Ser Asn Lys Ser Thr Glu Met Ala Leu Arg Val Ala Ser Leu Asp
            1060                1065                1070        
Tyr Leu Gly Thr Val Ala Ala Arg Leu Arg Lys Asp Ala Val Thr Ser
        1075                1080                1085            
Lys Met Asp Gln Gly Ser Ile Glu Arg Ile Leu Lys Gln Val Ser Gly
    1090                1095                1100                
Gly Glu Asp Glu Ile Gln Gln Leu Gln Lys Ala Leu Leu Asp Tyr Leu
1105                1110                1115                1120
Asp Glu Asn Thr Glu Thr Asp Pro Ser Leu Val Phe Ser Arg Lys Phe
                1125                1130                1135    
Tyr Ile Ala Gln Trp Phe Arg Asp Thr Thr Leu Glu Thr Glu Lys Ala
            1140                1145                1150        
Met Lys Ser Gln Lys Asp Glu Glu Ser Ser Glu Gly Thr His His Ala
        1155                1160                1165            
Lys Glu Ile Glu Thr Thr Gly Gln Ile Met His Arg Ala Glu Asn Arg
    1170                1175                1180                
Lys Lys Phe Leu Arg Ser Ile Ile Lys Thr Thr Pro Ser Gln Phe Ser
1185                1190                1195                1200
Thr Leu Lys Met Asn Ser Asp Thr Val Asp Tyr Asp Asp Ala Cys Leu
                1205                1210                1215    
Ile Val Arg Tyr Leu Ala Ser Met Arg Pro Phe Ala Gln Ser Phe Asp
            1220                1225                1230        
Ile Tyr Leu Thr Gln Ile Leu Arg Val Leu Gly Glu Asn Ala Ile Ala
        1235                1240                1245            
Val Arg Thr Lys Ala Met Lys Cys Leu Ser Glu Val Val Ala Val Asp
    1250                1255                1260                
Pro Ser Ile Leu Ala Arg Leu Asp Met Gln Arg Gly Val His Gly Arg
1265                1270                1275                1280
Leu Met Asp Asn Ser Thr Ser Val Arg Glu Ala Ala Val Glu Leu Leu
                1285                1290                1295    
Gly Arg Phe Val Leu Cys Arg Pro Gln Leu Ala Glu Gln Tyr Tyr Asp
            1300                1305                1310        
Met Leu Ile Glu Arg Ile Leu Asp Thr Gly Ile Ser Val Arg Lys Arg
        1315                1320                1325            
Val Ile Lys Ile Leu Arg Asp Ile Cys Ile Glu Gln Pro Thr Phe Pro
    1330                1335                1340                
Lys Ile Thr Glu Met Cys Val Lys Met Ile Arg Arg Val Asn Asp Glu
1345                1350                1355                1360
Glu Gly Ile Lys Lys Leu Val Asn Glu Thr Phe Gln Lys Leu Trp Phe
                1365                1370                1375    
Thr Pro Thr Pro His Asn Asp Lys Glu Ala Met Thr Arg Lys Ile Leu
            1380                1385                1390        
Asn Ile Thr Asp Val Val Ala Ala Cys Arg Asp Thr Gly Tyr Asp Trp
        1395                1400                1405            
Phe Glu Gln Leu Leu Gln Asn Leu Leu Lys Ser Glu Glu Asp Ser Ser
    1410                1415                1420                
Tyr Lys Pro Val Lys Lys Ala Cys Thr Gln Leu Val Asp Asn Leu Val
1425                1430                1435                1440
Glu His Ile Leu Lys Tyr Glu Glu Ser Leu Ala Asp Ser Asp Asn Lys
                1445                1450                1455    
Gly Val Asn Ser Gly Arg Leu Val Ala Cys Ile Thr Thr Leu Phe Leu
            1460                1465                1470        
Phe Ser Lys Ile Arg Pro Gln Leu Met Val Lys His Ala Met Thr Met
        1475                1480                1485            
Gln Pro Tyr Leu Thr Thr Lys Cys Ser Thr Gln Asn Asp Phe Met Val
    1490                1495                1500                
Ile Cys Asn Val Ala Lys Ile Leu Glu Leu Val Val Pro Leu Met Glu
1505                1510                1515                1520
His Pro Ser Glu Thr Phe Leu Ala Thr Ile Glu Glu Asp Leu Met Lys
                1525                1530                1535    
Leu Ile Ile Lys Tyr Gly Met Thr Val Val Gln His Cys Val Ser Cys
            1540                1545                1550        
Leu Gly Ala Val Val Asn Lys Val Thr Gln Asn Phe Lys Phe Val Trp
        1555                1560                1565            
Ala Cys Phe Asn Arg Tyr Tyr Gly Ala Ile Ser Lys Leu Lys Ser Gln
    1570                1575                1580                
His Gln Glu Asp Pro Asn Asn Thr Ser Leu Leu Thr Asn Lys Pro Ala
1585                1590                1595                1600
Leu Leu Arg Ser Leu Phe Thr Val Gly Ala Leu Cys Arg His Phe Asp
                1605                1610                1615    
Phe Asp Leu Glu Asp Phe Lys Gly Asn Ser Lys Val Asn Ile Lys Asp
            1620                1625                1630        
Lys Val Leu Glu Leu Leu Met Tyr Phe Thr Lys His Ser Asp Glu Glu
        1635                1640                1645            
Val Gln Thr Lys Ala Ile Ile Gly Leu Gly Phe Ala Phe Ile Gln His
    1650                1655                1660                
Pro Ser Leu Met Phe Glu Gln Glu Val Lys Asn Leu Tyr Asn Asn Ile
1665                1670                1675                1680
Leu Ser Asp Lys Asn Ser Ser Val Asn Leu Lys Ile Gln Val Leu Lys
                1685                1690                1695    
Asn Leu Gln Thr Tyr Leu Gln Glu Glu Asp Thr Arg Met Gln Gln Ala
            1700                1705                1710        
Asp Arg Asp Trp Lys Lys Val Ala Lys Gln Glu Asp Leu Lys Glu Met
        1715                1720                1725            
Gly Asp Val Ser Ser Gly Met Ser Ser Ser Ile Met Gln Leu Tyr Leu
    1730                1735                1740                
Lys Gln Val Leu Glu Ala Phe Phe His Thr Gln Ser Ser Val Arg His
1745                1750                1755                1760
Phe Ala Leu Asn Val Ile Ala Leu Thr Leu Asn Gln Gly Leu Ile His
                1765                1770                1775    
Pro Val Gln Cys Val Pro Tyr Leu Ile Ala Met Gly Thr Asp Pro Glu
            1780                1785                1790        
Pro Ala Met Arg Asn Lys Ala Asp Gln Gln Leu Val Glu Ile Asp Lys
        1795                1800                1805            
Lys Tyr Ala Gly Phe Ile His Met Lys Ala Val Ala Gly Met Lys Met
    1810                1815                1820                
Ser Tyr Gln Val Gln Gln Ala Ile Asn Thr Cys Leu Lys Asp Pro Val
1825                1830                1835                1840
Arg Gly Phe Arg Gln Asp Glu Ser Ser Ser Ala Leu Cys Ser His Leu
                1845                1850                1855    
Tyr Ser Met Ile Arg Gly Asn Arg Gln His Arg Arg Ala Phe Leu Ile
            1860                1865                1870        
Ser Leu Leu Asn Leu Phe Asp Asp Thr Ala Lys Thr Asp Val Thr Met
        1875                1880                1885            
Leu Leu Tyr Ile Ala Asp Asn Leu Ala Cys Phe Pro Tyr Gln Thr Gln
    1890                1895                1900                
Glu Glu Pro Leu Phe Ile Met His His Ile Asp Ile Thr Leu Ser Val
1905                1910                1915                1920
Ser Gly Ser Asn Leu Leu Gln Ser Phe Lys Glu Ser Met Val Lys Asp
                1925                1930                1935    
Lys Arg Lys Glu Arg Lys Ser Ser Pro Ser Lys Glu Asn Glu Ser Ser
            1940                1945                1950        
Asp Ser Glu Glu Glu Val Ser Arg Pro Arg Lys Ser Arg Lys Arg Val
        1955                1960                1965            
Asp Ser Asp Ser Asp Ser Asp Ser Glu Asp Asp Ile Asn Ser Val Met
    1970                1975                1980                
Lys Cys Leu Pro Glu Asn Ser Ala Pro Leu Ile Glu Phe Ala Asn Val
1985                1990                1995                2000
Ser Gln Gly Ile Leu Leu Leu Leu Met Leu Lys Gln His Leu Lys Asn
                2005                2010                2015    
Leu Cys Gly Phe Ser Asp Ser Lys Ile Gln Lys Tyr Ser Pro Ser Glu
            2020                2025                2030        
Ser Ala Lys Val Tyr Asp Lys Ala Ile Asn Arg Lys Thr Gly Val His
        2035                2040                2045            
Phe His Pro Lys Gln Thr Leu Asp Phe Leu Arg Ser Asp Met Ala Asn
    2050                2055                2060                
Ser Lys Ile Thr Glu Glu Val Lys Arg Ser Ile Val Lys Gln Tyr Leu
2065                2070                2075                2080
Asp Phe Lys Leu Leu Met Glu His Leu Asp Pro Asp Glu Glu Glu Glu
                2085                2090                2095    
Glu Gly Glu Val Ser Ala Ser Thr Asn Ala Arg Asn Lys Ala Ile Thr
            2100                2105                2110        
Ser Leu Leu Gly Gly Gly Ser Pro Lys Asn Asn Thr Ala Ala Glu Thr
        2115                2120                2125            
Glu Asp Asp Glu Ser Asp Gly Glu Asp Arg Gly Gly Gly Thr Ser Gly
    2130                2135                2140                
Val Arg Arg Arg Arg Ser Gln Arg Ile Ser Gln Arg Ile Thr
2145                2150                2155            


<210> 8175
<211> 1669
<212> PRT
<213> Homo sapiens

<400> 8175
Met Pro Lys Thr His Gly Ala Ile Arg Gln Ser Leu Gly Leu Gln Val
 1               5                  10                  15      
Ala Gly Ala Met Arg Leu Gly Cys Trp Ala Phe Val Lys Gly Tyr Ala
            20                  25                  30          
Lys Asp Met Val Thr Asp Phe Asp Glu Lys His Asp Glu Tyr Leu Ile
        35                  40                  45              
Leu Leu Gln Gln Arg Asn Arg Ile Leu Lys His Leu Lys Ser Lys Asp
    50                  55                  60                  
Pro Val Gln Leu Arg Leu Glu His Leu Glu Gln Gly Phe Ser Val Tyr
65                  70                  75                  80  
Val Asn Gly Ala Asn Ser Glu Leu Lys Ser Ser Pro Arg Lys Ala Ile
                85                  90                  95      
His Ser Asp Phe Ser Arg Ser Ala Ser His Thr Glu Gly Thr His Asp
            100                 105                 110         
Tyr Gly Arg Arg Thr Leu Phe Arg Glu Ala Glu Glu Ala Leu Arg Arg
        115                 120                 125             
Ser Ser Arg Thr Ala Pro Ser Lys Val Gln Arg Arg Gly Trp His Gln
    130                 135                 140                 
Lys Ser Val Gln Ile Arg Thr Glu Ala Gly Pro Arg Leu His Ile Glu
145                 150                 155                 160 
Pro Pro Val Asp Tyr Ser Asp Asp Phe Glu Leu Cys Gly Asp Val Thr
                165                 170                 175     
Leu Gln Ala Asn Asn Thr Ser Glu Asp Arg Pro Gln Asp Thr Lys Ser
            180                 185                 190         
Pro Thr Ser Thr Lys Pro Cys Gly Phe Asn Phe Ser Leu Leu Asn Ala
        195                 200                 205             
Cys Gly His Ser Asp Pro Ser Ser Ser Val Asp Lys Glu Arg Ile Leu
    210                 215                 220                 
Leu Thr Ile Gln Asp Val Met Glu Leu Arg Arg Ser Leu Glu Leu Ser
225                 230                 235                 240 
Val Asn Leu Gln Arg Lys Gln Lys Asp Cys Ser Ser Asp Glu Tyr Asp
                245                 250                 255     
Ser Ile Glu Glu Asp Ile Leu Ser Glu Pro Glu Pro Glu Asp Pro Ala
            260                 265                 270         
Leu Val Gly His Pro Arg His Asp Arg Pro Pro Ser Ser Gly Asp Trp
        275                 280                 285             
Thr Gln Lys Asp Val His Gly Glu Gln Glu Thr Glu Gly Arg Ser Ser
    290                 295                 300                 
Pro Gly Pro Asp Thr Leu Val Val Leu Glu Phe Asn Pro Ala Ser Lys
305                 310                 315                 320 
Ser His Lys Arg Glu Arg Asn Leu Ser Ala Lys Arg Lys Asp Asn Ala
                325                 330                 335     
Glu Val Phe Val Pro Thr Lys Pro Glu Pro Asn Leu Thr Pro Gln Ala
            340                 345                 350         
Pro Ala Val Phe Pro Asp Gln Glu Arg Met Cys Ser Arg Pro Gly Ser
        355                 360                 365             
Arg Arg Glu Arg Pro Leu Ser Ala Thr Arg Lys Thr Leu Cys Glu Ala
    370                 375                 380                 
Glu Tyr Pro Glu Glu Asp Ala Ser Ala Val Leu Gln Ala Ile Gln Val
385                 390                 395                 400 
Glu Asn Ala Ala Leu Gln Arg Ala Leu Leu Ser Arg Lys Ala Glu Gln
                405                 410                 415     
Pro Ala Ser Pro Leu Gln Asp Ala Glu Gly Pro Pro Ala Lys Pro Trp
            420                 425                 430         
Thr Ser Leu Leu Glu Glu Lys Glu Glu Thr Leu Glu Leu Leu Pro Ile
        435                 440                 445             
Thr Thr Ala Thr Thr Thr Gln Glu Pro Ala Gly Ala Ala Gly Gly Ala
    450                 455                 460                 
Arg Ala Ile Asn Gln Ala Met Asp Arg Ile Gly Leu Leu Gly Ser Arg
465                 470                 475                 480 
Gln Gln Gln Lys Leu Leu Lys Val Leu Gln Ala Val Glu Ser Asp Ser
                485                 490                 495     
Ala His Leu Gly Arg Val Val Ser Pro Thr Lys Glu Gln Val Ser Asp
            500                 505                 510         
Thr Glu Asp Lys Gln Arg Met Arg Ala Asp Glu Ile Lys Asp Ala Ile
        515                 520                 525             
Tyr Val Thr Met Glu Ile Leu Ser Asn Trp Gly Asn Ser Trp Trp Val
    530                 535                 540                 
Gly Leu Thr Glu Val Glu Phe Phe Asp Leu Asn Asp Thr Lys Leu Tyr
545                 550                 555                 560 
Val Ser Pro His Asp Val Asp Ile Arg Asn Thr Ala Thr Pro Gly Glu
                565                 570                 575     
Leu Gly Arg Leu Val Asn Arg Asn Leu Ala Gly Lys Lys Asp Ser Ser
            580                 585                 590         
Pro Trp Thr Cys Pro Phe His Pro Pro Leu Gln Leu Phe Phe Val Ile
        595                 600                 605             
Arg Asn Thr Arg Gln Leu Gly Asp Phe His Leu Ala Lys Ile Lys Val
    610                 615                 620                 
Arg Asn Tyr Trp Thr Ala Asp Gly Asp Leu Asp Ile Gly Ala Lys Asn
625                 630                 635                 640 
Val Lys Leu Tyr Val Asn Arg Asn Leu Ile Phe Asn Gly Lys Leu Asp
                645                 650                 655     
Lys Gly Asp Arg Glu Ala Pro Ala Asp His Ser Ile Leu Val Asp Gln
            660                 665                 670         
Lys Asn Glu Lys Ser Glu Gln Leu Glu Glu Ala Met Asn Ala His Ser
        675                 680                 685             
Glu Glu Ser Lys Gly Thr His Glu Met Ala Gly Ala Ser Gly Asp Lys
    690                 695                 700                 
Glu Leu Gly Leu Gly Cys Ser Pro Pro Ala Glu Thr Leu Ala Asp Ala
705                 710                 715                 720 
Lys Leu Ser Ser Gln Gly Asn Val Ser Gly Lys Arg Lys Asn Ser Thr
                725                 730                 735     
Asn Cys Arg Lys Asp Ser Leu Ser Gln Leu Glu Glu Tyr Leu Arg Leu
            740                 745                 750         
Ser Ala Val Pro Thr Ser Met Gly Asp Met Pro Ser Ala Pro Ala Thr
        755                 760                 765             
Ser Pro Pro Val Lys Cys Pro Pro Val His Glu Glu Pro Ser Leu Ile
    770                 775                 780                 
Gln Gln Leu Glu Asn Leu Met Gly Arg Lys Ile Cys Glu Pro Pro Gly
785                 790                 795                 800 
Lys Thr Pro Ser Trp Leu Gln Pro Ser Pro Thr Gly Lys Asp Arg Lys
                805                 810                 815     
Gln Gly Gly Arg Lys Pro Lys Pro Leu Trp Leu Ser Pro Glu Lys Pro
            820                 825                 830         
Leu Ala Trp Lys Gly Arg Leu Pro Ser Asp Asp Val Ile Gly Glu Gly
        835                 840                 845             
Pro Gly Glu Thr Glu Ala Arg Asp Lys Gly Leu Arg His Glu Pro Gly
    850                 855                 860                 
Trp Gly Thr Ser Arg Ser Val Asn Thr Lys Glu Arg Pro Gln Arg Ala
865                 870                 875                 880 
Thr Thr Lys Val His Ser Asp Asp Ser Asp Ile Phe Asn Gln Pro Pro
                885                 890                 895     
Asn Arg Glu Arg Pro Ala Ser Gly Arg Arg Gly Ser Arg Lys Asp Ala
            900                 905                 910         
Gly Ser Ser Ser His Gly Asp Asp Gln Pro Ala Ser Arg Glu Asp Thr
        915                 920                 925             
Trp Ser Ser Arg Thr Pro Ser Arg Ser Arg Trp Arg Ser Glu Gln Glu
    930                 935                 940                 
His Thr Leu His Glu Ser Trp Ser Ser Leu Ser Ala Phe Asp Arg Ser
945                 950                 955                 960 
His Arg Gly Arg Ile Ser Asn Thr Glu Leu Pro Gly Asp Ile Leu Asp
                965                 970                 975     
Glu Leu Leu Gln Gln Lys Ser Ser Arg His Ser Asp Leu Pro Pro Ser
            980                 985                 990         
Lys Lys Gly Glu Gln Pro Gly Leu Ser Arg Gly Gln Asp Gly Tyr Ser
        995                 1000                1005            
Gly Glu Thr Asp Ala Gly Gly Asp Phe Lys Ile Pro Val Leu Pro Tyr
    1010                1015                1020                
Gly Gln Arg Leu Val Ile Asp Ile Lys Ser Thr Trp Gly Asp Arg His
1025                1030                1035                1040
Tyr Val Gly Leu Asn Gly Ile Glu Ile Phe Ser Ser Lys Gly Glu Pro
                1045                1050                1055    
Val Gln Ile Ser Asn Ile Lys Ala Asp Pro Pro Asp Ile Asn Ile Leu
            1060                1065                1070        
Pro Ala Tyr Gly Lys Asp Pro Arg Val Val Thr Asn Leu Ile Asp Gly
        1075                1080                1085            
Val Asn Arg Thr Gln Asp Asp Met His Val Trp Leu Ala Pro Phe Thr
    1090                1095                1100                
Arg Gly Arg Ser His Ser Ile Thr Ile Asp Phe Thr His Pro Cys His
1105                1110                1115                1120
Val Ala Leu Ile Arg Ile Trp Asn Tyr Asn Lys Ser Arg Ile His Ser
                1125                1130                1135    
Phe Arg Gly Val Lys Asp Ile Thr Met Leu Leu Asp Thr Gln Cys Ile
            1140                1145                1150        
Phe Glu Gly Glu Ile Ala Lys Ala Ser Gly Thr Leu Ala Gly Ala Pro
        1155                1160                1165            
Glu His Phe Gly Asp Thr Ile Leu Phe Thr Thr Asp Asp Asp Ile Leu
    1170                1175                1180                
Glu Ala Ile Phe Tyr Ser Asp Glu Met Phe Asp Leu Asp Val Gly Ser
1185                1190                1195                1200
Leu Asp Ser Leu Gln Asp Glu Glu Ala Met Arg Arg Pro Ser Thr Ala
                1205                1210                1215    
Asp Gly Glu Gly Asp Glu Arg Pro Phe Thr Gln Ala Gly Leu Gly Ala
            1220                1225                1230        
Asp Glu Arg Ile Pro Glu Leu Glu Leu Pro Ser Ser Ser Pro Val Pro
        1235                1240                1245            
Gln Val Thr Thr Pro Glu Pro Gly Ile Tyr His Gly Ile Cys Leu Gln
    1250                1255                1260                
Leu Asn Phe Thr Ala Ser Trp Gly Asp Leu His Tyr Leu Gly Leu Thr
1265                1270                1275                1280
Gly Leu Glu Val Val Gly Lys Glu Gly Gln Ala Leu Pro Ile His Leu
                1285                1290                1295    
His Gln Ile Ser Ala Ser Pro Arg Asp Leu Asn Glu Leu Pro Glu Tyr
            1300                1305                1310        
Ser Asp Asp Ser Arg Ala Leu Asp Lys Leu Ile Asp Gly Thr Asn Ile
        1315                1320                1325            
Thr Met Glu Asp Glu His Met Trp Leu Ile Pro Phe Ser Pro Gly Leu
    1330                1335                1340                
Asp His Val Val Thr Ile Arg Leu Asp Arg Ala Glu Ser Ile Ala Gly
1345                1350                1355                1360
Leu Arg Phe Trp Asn Tyr Asn Lys Ser Pro Glu Asp Thr Tyr Arg Gly
                1365                1370                1375    
Ala Lys Ile Val His Val Ser Leu Asp Gly Leu Cys Val Ser Pro Pro
            1380                1385                1390        
Glu Gly Phe Leu Ile Arg Lys Gly Pro Gly Asn Cys His Phe Asp Phe
        1395                1400                1405            
Ala Gln Glu Ile Leu Phe Val Asp Tyr Leu Arg Ala Gln Leu Leu Pro
    1410                1415                1420                
Gln Pro Ala Arg Arg Leu Asp Met Arg Ser Leu Glu Cys Ala Ser Met
1425                1430                1435                1440
Asp Tyr Glu Ala Pro Leu Met Pro Cys Gly Phe Ile Phe Gln Phe Gln
                1445                1450                1455    
Leu Leu Thr Ser Trp Gly Asp Pro Tyr Tyr Ile Gly Leu Thr Gly Leu
            1460                1465                1470        
Glu Leu Tyr Asp Glu Arg Gly Glu Lys Ile Pro Leu Ser Glu Asn Asn
        1475                1480                1485            
Ile Ala Ala Phe Pro Asp Ser Val Asn Ser Leu Glu Gly Val Gly Gly
    1490                1495                1500                
Asp Val Arg Thr Pro Asp Lys Leu Ile Asp Gln Val Asn Asp Thr Ser
1505                1510                1515                1520
Asp Gly Arg His Met Trp Leu Ala Pro Ile Leu Pro Gly Leu Val Asn
                1525                1530                1535    
Arg Val Tyr Val Ile Phe Asp Leu Pro Thr Thr Val Ser Met Ile Lys
            1540                1545                1550        
Leu Trp Asn Tyr Ala Lys Thr Pro His Arg Gly Val Lys Glu Phe Gly
        1555                1560                1565            
Leu Leu Val Asp Asp Leu Leu Val Tyr Asn Gly Ile Leu Ala Met Val
    1570                1575                1580                
Ser His Leu Val Gly Gly Ile Leu Pro Thr Cys Glu Pro Thr Val Pro
1585                1590                1595                1600
Tyr His Thr Ile Leu Phe Thr Glu Asp Arg Asp Ile Arg His Gln Glu
                1605                1610                1615    
Lys His Thr Thr Ile Ser Asn Gln Ala Glu Asp Gln Asp Val Gln Met
            1620                1625                1630        
Met Asn Glu Asn Gln Ile Ile Thr Asn Ala Lys Arg Lys Gln Ser Val
        1635                1640                1645            
Val Asp Pro Ala Leu Arg Pro Lys Thr Cys Ile Ser Glu Lys Glu Thr
    1650                1655                1660                
Arg Arg Arg Arg Cys
1665                


<210> 8176
<211> 899
<212> PRT
<213> Homo sapiens

<400> 8176
Val Phe Ser Lys Arg Pro Pro His Gly Phe Leu Met Asp Arg Ser Ser
 1               5                  10                  15      
Lys Arg Arg Gln Val Lys Pro Leu Ala Ala Ser Leu Leu Glu Ala Leu
            20                  25                  30          
Asp Tyr Asp Ser Ser Asp Asp Ser Asp Phe Lys Val Gly Asp Ala Ser
        35                  40                  45              
Asp Ser Glu Gly Ser Gly Asn Gly Ser Glu Asp Ala Ser Lys Asp Ser
    50                  55                  60                  
Gly Glu Gly Ser Cys Ser Asp Ser Glu Glu Asn Ile Leu Glu Glu Glu
65                  70                  75                  80  
Leu Asn Glu Asp Ile Lys Val Lys Glu Glu Gln Leu Lys Asn Ser Ala
                85                  90                  95      
Glu Glu Glu Val Leu Ser Ser Glu Lys Gln Leu Ile Lys Met Glu Lys
            100                 105                 110         
Lys Glu Glu Glu Glu Asn Gly Glu Arg Pro Arg Lys Lys Lys Glu Lys
        115                 120                 125             
Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Arg Glu Lys
    130                 135                 140                 
Glu Lys Glu Lys Ala Thr Val Ser Glu Asn Val Ala Ala Ser Ala Ala
145                 150                 155                 160 
Ala Thr Thr Pro Ala Thr Ser Pro Pro Ala Val Asn Thr Ser Pro Ser
                165                 170                 175     
Val Pro Thr Thr Thr Thr Ala Thr Glu Glu Gln Val Ser Glu Pro Lys
            180                 185                 190         
Lys Trp Asn Leu Arg Arg Asn Arg Pro Leu Leu Asp Phe Val Ser Met
        195                 200                 205             
Glu Glu Leu Asn Asp Met Asp Asp Tyr Asp Ser Glu Asp Asp Asn Asp
    210                 215                 220                 
Trp Arg Pro Thr Val Val Lys Arg Lys Gly Arg Ser Ala Ser Gln Lys
225                 230                 235                 240 
Glu Gly Ser Asp Gly Asp Asn Glu Asp Asp Glu Asp Glu Gly Ser Gly
                245                 250                 255     
Ser Asp Glu Asp Glu Asn Asp Glu Gly Asn Asp Glu Asp His Ser Ser
            260                 265                 270         
Pro Ala Ser Glu Gly Gly Cys Lys Lys Lys Lys Ser Lys Val Leu Ser
        275                 280                 285             
Arg Asn Ser Ala Asp Asp Glu Glu Leu Thr Asn Asp Ser Leu Thr Leu
    290                 295                 300                 
Ser Gln Ser Lys Ser Asn Glu Asp Ser Leu Ile Leu Glu Lys Ser Gln
305                 310                 315                 320 
Asn Trp Ser Ser Gln Lys Met Asp His Ile Leu Ile Cys Cys Val Cys
                325                 330                 335     
Leu Gly Asp Asn Ser Glu Asp Ala Asp Glu Ile Ile Gln Cys Asp Asn
            340                 345                 350         
Cys Gly Ile Thr Val His Glu Gly Cys Tyr Gly Val Asp Gly Glu Ser
        355                 360                 365             
Asp Ser Ile Met Ser Ser Ala Ser Glu Asn Ser Thr Glu Pro Trp Phe
    370                 375                 380                 
Cys Asp Ala Cys Lys Cys Gly Val Ser Pro Ser Cys Glu Leu Cys Pro
385                 390                 395                 400 
Asn Gln Asp Gly Ile Phe Lys Glu Thr Asp Ala Gly Arg Trp Val His
                405                 410                 415     
Ile Val Cys Ala Leu Tyr Val Pro Gly Val Ala Phe Gly Asp Ile Asp
            420                 425                 430         
Lys Leu Arg Pro Val Thr Leu Thr Glu Met Asn Tyr Ser Lys Tyr Gly
        435                 440                 445             
Ala Lys Glu Cys Ser Phe Cys Glu Asp Pro Arg Phe Ala Arg Thr Gly
    450                 455                 460                 
Val Cys Ile Ser Cys Asp Ala Gly Met Cys Arg Ala Tyr Phe His Val
465                 470                 475                 480 
Thr Cys Ala Gln Lys Glu Gly Leu Leu Ser Glu Ala Ala Ala Glu Glu
                485                 490                 495     
Asp Ile Ala Asp Pro Phe Phe Ala Tyr Cys Lys Gln His Ala Asp Arg
            500                 505                 510         
Leu Asp Arg Lys Trp Lys Arg Lys Asn Tyr Leu Ala Leu Gln Ser Tyr
        515                 520                 525             
Cys Lys Met Ser Leu Gln Glu Arg Glu Lys Gln Leu Ser Pro Glu Ala
    530                 535                 540                 
Gln Ala Arg Ile Asn Ala Arg Leu Gln Gln Tyr Arg Ala Lys Ala Glu
545                 550                 555                 560 
Leu Ala Arg Ser Thr Arg Pro Gln Ala Trp Val Pro Arg Glu Lys Leu
                565                 570                 575     
Pro Arg Pro Leu Thr Ser Ser Ala Ser Ala Ile Arg Lys Leu Met Arg
            580                 585                 590         
Lys Ala Glu Leu Met Gly Ile Ser Thr Asp Ile Phe Pro Val Asp Asn
        595                 600                 605             
Ser Asp Thr Ser Ser Ser Val Asp Gly Arg Arg Lys His Lys Gln Pro
    610                 615                 620                 
Ala Leu Thr Ala Asp Phe Val Asn Tyr Tyr Phe Glu Arg Asn Met Arg
625                 630                 635                 640 
Met Ile Gln Ile Gln Glu Asn Met Ala Glu Gln Lys Asn Ile Lys Asp
                645                 650                 655     
Lys Leu Glu Asn Glu Gln Glu Lys Leu His Val Glu Tyr Asn Lys Leu
            660                 665                 670         
Cys Glu Ser Leu Glu Glu Leu Gln Asn Leu Asn Gly Lys Leu Arg Ser
        675                 680                 685             
Glu Gly Gln Gly Ile Trp Ala Leu Leu Gly Arg Ile Thr Gly Gln Lys
    690                 695                 700                 
Leu Asn Ile Pro Ala Ile Leu Arg Ala Pro Lys Glu Arg Lys Pro Ser
705                 710                 715                 720 
Lys Lys Glu Gly Gly Thr Gln Lys Thr Ser Thr Leu Pro Ala Val Leu
                725                 730                 735     
Tyr Ser Cys Gly Ile Cys Lys Lys Asn His Asp Gln His Leu Leu Leu
            740                 745                 750         
Leu Cys Asp Thr Cys Lys Leu His Tyr His Leu Gly Cys Leu Asp Pro
        755                 760                 765             
Pro Leu Thr Arg Met Pro Arg Lys Thr Lys Asn Ser Tyr Trp Gln Cys
    770                 775                 780                 
Ser Glu Cys Asp Gln Ala Gly Ser Ser Asp Met Glu Ala Asp Met Ala
785                 790                 795                 800 
Met Glu Thr Leu Pro Asp Gly Thr Lys Arg Ser Arg Arg Gln Ile Lys
                805                 810                 815     
Glu Pro Val Lys Phe Val Pro Gln Asp Val Pro Pro Glu Pro Lys Lys
            820                 825                 830         
Ile Pro Ile Arg Asn Thr Arg Thr Arg Gly Arg Lys Arg Ser Phe Val
        835                 840                 845             
Pro Glu Glu Glu Lys His Glu Glu Arg Val Pro Arg Glu Arg Arg Gln
    850                 855                 860                 
Arg Gln Ser Val Leu Gln Lys Lys Pro Lys Ala Glu Asp Leu Arg Thr
865                 870                 875                 880 
Glu Cys Ala Thr Cys Lys Gly Thr Gly Asp Asn Glu Asn Leu Val Arg
                885                 890                 895     
Tyr Pro Ser
            


<210> 8177
<211> 1005
<212> PRT
<213> Homo sapiens

<400> 8177
Leu Leu Ser Arg Met Pro Ser Thr Asn Arg Ala Gly Ser Leu Lys Asp
 1               5                  10                  15      
Pro Glu Ile Ala Glu Leu Phe Phe Lys Glu Asp Pro Glu Lys Leu Phe
            20                  25                  30          
Thr Asp Leu Arg Glu Ile Gly His Gly Ser Phe Gly Ala Val Tyr Phe
        35                  40                  45              
Ala Arg Asp Val Arg Thr Asn Glu Val Val Ala Ile Lys Lys Met Ser
    50                  55                  60                  
Tyr Ser Gly Lys Gln Ser Thr Glu Lys Trp Gln Asp Ile Ile Lys Glu
65                  70                  75                  80  
Val Lys Phe Leu Gln Arg Ile Lys His Pro Asn Ser Ile Glu Tyr Lys
                85                  90                  95      
Gly Cys Tyr Leu Arg Glu His Thr Ala Trp Leu Val Met Glu Tyr Cys
            100                 105                 110         
Leu Gly Ser Ala Ser Asp Leu Leu Glu Val His Lys Lys Pro Leu Gln
        115                 120                 125             
Glu Val Glu Ile Ala Ala Ile Thr His Gly Ala Leu Gln Gly Leu Ala
    130                 135                 140                 
Tyr Leu His Ser His Thr Met Ile His Arg Asp Ile Lys Ala Gly Asn
145                 150                 155                 160 
Ile Leu Leu Thr Glu Pro Gly Gln Val Lys Leu Ala Asp Phe Gly Ser
                165                 170                 175     
Ala Ser Met Ala Ser Pro Ala Asn Ser Phe Val Gly Thr Pro Tyr Trp
            180                 185                 190         
Met Ala Pro Glu Val Ile Leu Ala Met Asp Glu Gly Gln Tyr Asp Gly
        195                 200                 205             
Lys Val Asp Val Trp Ser Leu Gly Ile Thr Cys Ile Glu Leu Ala Glu
    210                 215                 220                 
Arg Lys Pro Pro Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His
225                 230                 235                 240 
Ile Ala Gln Asn Glu Ser Pro Thr Leu Gln Ser Asn Glu Trp Ser Asp
                245                 250                 255     
Tyr Phe Arg Asn Phe Val Asp Ser Cys Leu Gln Lys Ile Pro Gln Asp
            260                 265                 270         
Arg Pro Thr Ser Glu Glu Leu Leu Lys His Ile Phe Val Leu Arg Glu
        275                 280                 285             
Arg Pro Glu Thr Val Leu Ile Asp Leu Ile Gln Arg Thr Lys Asp Ala
    290                 295                 300                 
Val Arg Glu Leu Asp Asn Leu Gln Tyr Arg Lys Met Lys Lys Leu Leu
305                 310                 315                 320 
Phe Gln Glu Ala His Asn Gly Pro Ala Val Glu Ala Gln Glu Glu Glu
                325                 330                 335     
Glu Glu Gln Asp His Gly Val Gly Arg Thr Gly Thr Val Asn Ser Val
            340                 345                 350         
Gly Ser Asn Gln Ser Ile Pro Ser Met Ser Ile Ser Ala Ser Ser Gln
        355                 360                 365             
Ser Ser Ser Val Asn Ser Leu Pro Asp Val Ser Asp Asp Lys Ser Glu
    370                 375                 380                 
Leu Asp Met Met Glu Gly Asp His Thr Val Met Ser Asn Ser Ser Val
385                 390                 395                 400 
Ile His Leu Lys Pro Glu Glu Glu Asn Tyr Arg Glu Glu Gly Asp Pro
                405                 410                 415     
Arg Thr Arg Ala Ser Asp Pro Gln Ser Pro Pro Gln Val Ser Arg His
            420                 425                 430         
Lys Ser His Tyr Arg Asn Arg Glu His Phe Ala Thr Ile Arg Thr Ala
        435                 440                 445             
Ser Leu Val Thr Arg Gln Met Gln Glu His Glu Gln Asp Ser Glu Leu
    450                 455                 460                 
Arg Glu Gln Met Ser Gly Tyr Lys Arg Met Arg Arg Gln His Gln Lys
465                 470                 475                 480 
Gln Leu Met Thr Leu Glu Asn Lys Leu Lys Ala Glu Met Asp Glu His
                485                 490                 495     
Arg Leu Arg Leu Asp Lys Asp Leu Glu Thr Gln Arg Asn Asn Phe Ala
            500                 505                 510         
Ala Glu Met Glu Lys Leu Ile Lys Lys His Gln Ala Ala Met Glu Lys
        515                 520                 525             
Glu Ala Lys Val Met Ser Asn Glu Glu Lys Lys Phe Gln Gln His Ile
    530                 535                 540                 
Gln Ala Gln Gln Lys Lys Glu Leu Asn Ser Phe Leu Glu Ser Gln Lys
545                 550                 555                 560 
Arg Glu Tyr Lys Leu Arg Lys Glu Gln Leu Lys Glu Glu Leu Asn Glu
                565                 570                 575     
Asn Gln Ser Thr Pro Lys Lys Glu Lys Gln Glu Trp Leu Ser Lys Gln
            580                 585                 590         
Lys Glu Asn Ile Gln His Phe Gln Ala Glu Glu Glu Ala Asn Leu Leu
        595                 600                 605             
Arg Arg Gln Arg Gln Tyr Leu Glu Leu Glu Cys Arg Arg Phe Lys Arg
    610                 615                 620                 
Arg Met Leu Leu Gly Arg His Asn Leu Glu Gln Asp Leu Val Arg Glu
625                 630                 635                 640 
Glu Leu Asn Lys Arg Gln Thr Gln Lys Asp Leu Glu His Ala Met Leu
                645                 650                 655     
Leu Arg Gln His Glu Ser Met Gln Glu Leu Glu Phe Arg His Leu Asn
            660                 665                 670         
Thr Ile Gln Lys Met Arg Cys Glu Leu Ile Arg Leu Gln His Gln Thr
        675                 680                 685             
Glu Leu Thr Asn Gln Leu Glu Tyr Asn Lys Arg Arg Glu Arg Glu Leu
    690                 695                 700                 
Arg Arg Lys His Val Met Glu Val Arg Gln Gln Pro Lys Ser Leu Lys
705                 710                 715                 720 
Ser Lys Glu Leu Gln Ile Lys Lys Gln Phe Gln Asp Thr Cys Lys Ile
                725                 730                 735     
Gln Thr Arg Gln Tyr Lys Ala Leu Arg Asn His Leu Leu Glu Thr Thr
            740                 745                 750         
Pro Lys Ser Glu His Lys Ala Val Leu Lys Arg Leu Lys Glu Glu Gln
        755                 760                 765             
Thr Arg Lys Leu Ala Ile Leu Ala Glu Gln Tyr Asp His Ser Ile Asn
    770                 775                 780                 
Glu Met Leu Ser Thr Gln Ala Leu Arg Leu Asp Glu Ala Gln Glu Ala
785                 790                 795                 800 
Glu Cys Gln Val Leu Lys Met Gln Leu Gln Gln Glu Leu Glu Leu Leu
                805                 810                 815     
Asn Ala Tyr Gln Ser Lys Ile Lys Met Gln Ala Glu Ala Gln His Asp
            820                 825                 830         
Arg Glu Leu Arg Glu Leu Glu Gln Arg Val Ser Leu Arg Arg Ala Leu
        835                 840                 845             
Leu Glu Gln Lys Ile Glu Glu Glu Met Leu Ala Leu Gln Asn Glu Arg
    850                 855                 860                 
Thr Glu Arg Ile Arg Ser Leu Leu Glu Arg Gln Ala Arg Glu Ile Glu
865                 870                 875                 880 
Ala Phe Asp Ser Glu Ser Met Arg Leu Gly Phe Ser Asn Met Val Leu
                885                 890                 895     
Ser Asn Leu Ser Pro Glu Ala Phe Ser His Ser Tyr Pro Gly Ala Ser
            900                 905                 910         
Gly Trp Ser His Asn Pro Thr Gly Gly Pro Gly Pro His Trp Gly His
        915                 920                 925             
Pro Met Gly Gly Pro Pro Gln Ala Trp Gly His Pro Met Gln Gly Gly
    930                 935                 940                 
Pro Gln Pro Trp Gly His Pro Ser Gly Pro Met Gln Gly Val Pro Arg
945                 950                 955                 960 
Gly Ser Ser Met Gly Val Arg Asn Ser Pro Gln Ala Leu Arg Arg Thr
                965                 970                 975     
Ala Ser Gly Gly Arg Thr Glu Gln Gly Met Ser Arg Ser Thr Ser Val
            980                 985                 990         
Thr Ser Gln Ile Ser Asn Gly Ser His Met Ser Tyr Thr
        995                 1000                1005


<210> 8178
<211> 72
<212> PRT
<213> Homo sapiens

<400> 8178
Met Leu Leu Asn Asp Lys Trp Val Asn Glu Glu Ile Lys Lys Lys Ile
 1               5                  10                  15      
Glu Lys Cys Leu Glu Thr Asn Asp Asn Gly Asn Thr Thr Tyr Gln Asn
            20                  25                  30          
Leu Trp Asp Thr Ala Lys Ala Val Val Arg Gly Lys Phe Ile Ala Ile
        35                  40                  45              
Ser Thr Tyr Ile Lys Lys Glu Glu Lys Leu Gln Ile Asn Asn Leu Thr
    50                  55                  60                  
Met Asn Leu Ile Glu Leu Glu Asn
65                  70          


<210> 8179
<211> 216
<212> PRT
<213> Homo sapiens

<400> 8179
Met Ala Gly Arg Gly Gly Ala Ala Arg Pro Asn Gly Pro Ala Ala Gly
 1               5                  10                  15      
Asn Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val
            20                  25                  30          
Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu
        35                  40                  45              
Tyr Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys
    50                  55                  60                  
Leu Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln
65                  70                  75                  80  
Glu Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala
                85                  90                  95      
Ala Ile Val Val Tyr Asp Ile Thr Asn Thr Asp Thr Phe Ala Arg Ala
            100                 105                 110         
Lys Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val
        115                 120                 125             
Ile Ala Leu Ala Gly Asn Lys Ala Asp Leu Ala Ser Lys Arg Ala Val
    130                 135                 140                 
Glu Phe Gln Glu Ala Gln Ala Tyr Ala Asp Asp Asn Ser Leu Leu Phe
145                 150                 155                 160 
Met Glu Thr Ser Ala Lys Thr Ala Met Asn Val Asn Glu Ile Phe Met
                165                 170                 175     
Ala Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Ala Thr Gly
            180                 185                 190         
Ala Pro Gly Arg Asn Arg Gly Val Asp Leu Gln Glu Asn Asn Pro Ala
        195                 200                 205             
Ser Arg Ser Gln Cys Cys Ser Asn
    210                 215     


<210> 8180
<211> 1863
<212> PRT
<213> Homo sapiens

<400> 8180
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn
 1               5                  10                  15      
Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys
            20                  25                  30          
Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met
        35                  40                  45              
Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys
    50                  55                  60                  
Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser
65                  70                  75                  80  
Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp
                85                  90                  95      
Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn
            100                 105                 110         
Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met
        115                 120                 125             
Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn
    130                 135                 140                 
Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly
145                 150                 155                 160 
Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr
                165                 170                 175     
Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn
            180                 185                 190         
Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr
        195                 200                 205             
Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala
    210                 215                 220                 
Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln
225                 230                 235                 240 
Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg
                245                 250                 255     
His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu
            260                 265                 270         
Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser
        275                 280                 285             
Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe
    290                 295                 300                 
Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg
305                 310                 315                 320 
Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr
                325                 330                 335     
Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu
            340                 345                 350         
Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu
        355                 360                 365             
Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu
    370                 375                 380                 
Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp
385                 390                 395                 400 
Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu
                405                 410                 415     
Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu
            420                 425                 430         
Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His
        435                 440                 445             
Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr
    450                 455                 460                 
Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn
465                 470                 475                 480 
Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg
                485                 490                 495     
Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu
            500                 505                 510         
His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr
        515                 520                 525             
Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln
    530                 535                 540                 
Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp
545                 550                 555                 560 
Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys
                565                 570                 575     
Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser
            580                 585                 590         
Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys
        595                 600                 605             
Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu
    610                 615                 620                 
Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln
625                 630                 635                 640 
Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn
                645                 650                 655     
Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys
            660                 665                 670         
Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr
        675                 680                 685             
Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn
    690                 695                 700                 
Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu
705                 710                 715                 720 
Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu
                725                 730                 735     
Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu
            740                 745                 750         
Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser
        755                 760                 765             
Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser
    770                 775                 780                 
Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys
785                 790                 795                 800 
Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His
                805                 810                 815     
Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro
            820                 825                 830         
Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu
        835                 840                 845             
Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser
    850                 855                 860                 
Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu
865                 870                 875                 880 
Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser
                885                 890                 895     
Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys
            900                 905                 910         
Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly
        915                 920                 925             
Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys
    930                 935                 940                 
Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly
945                 950                 955                 960 
Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn
                965                 970                 975     
Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr
            980                 985                 990         
Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met
        995                 1000                1005            
Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val Ser
    1010                1015                1020                
Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala Ser
1025                1030                1035                1040
Ser Ser Asn Ile Asn Glu Val Gly Ser Ser Thr Asn Glu Val Gly Ser
                1045                1050                1055    
Ser Ile Asn Glu Ile Gly Ser Ser Asp Glu Asn Ile Gln Ala Glu Leu
            1060                1065                1070        
Gly Arg Asn Arg Gly Pro Lys Leu Asn Ala Met Leu Arg Leu Gly Val
        1075                1080                1085            
Leu Gln Pro Glu Val Tyr Lys Gln Ser Leu Pro Gly Ser Asn Cys Lys
    1090                1095                1100                
His Pro Glu Ile Lys Lys Gln Glu Tyr Glu Glu Val Val Gln Thr Val
1105                1110                1115                1120
Asn Thr Asp Phe Ser Pro Tyr Leu Ile Ser Asp Asn Leu Glu Gln Pro
                1125                1130                1135    
Met Gly Ser Ser His Ala Ser Gln Val Cys Ser Glu Thr Pro Asp Asp
            1140                1145                1150        
Leu Leu Asp Asp Gly Glu Ile Lys Glu Asp Thr Ser Phe Ala Glu Asn
        1155                1160                1165            
Asp Ile Lys Glu Ser Ser Ala Val Phe Ser Lys Ser Val Gln Lys Gly
    1170                1175                1180                
Glu Leu Ser Arg Ser Pro Ser Pro Phe Thr His Thr His Leu Ala Gln
1185                1190                1195                1200
Gly Tyr Arg Arg Gly Ala Lys Lys Leu Glu Ser Ser Glu Glu Asn Leu
                1205                1210                1215    
Ser Ser Glu Asp Glu Glu Leu Pro Cys Phe Gln His Leu Leu Phe Gly
            1220                1225                1230        
Lys Val Asn Asn Ile Pro Ser Gln Ser Thr Arg His Ser Thr Val Ala
        1235                1240                1245            
Thr Glu Cys Leu Ser Lys Asn Thr Glu Glu Asn Leu Leu Ser Leu Lys
    1250                1255                1260                
Asn Ser Leu Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys Ala Ser
1265                1270                1275                1280
Gln Glu His His Leu Ser Glu Glu Thr Lys Cys Ser Ala Ser Leu Phe
                1285                1290                1295    
Ser Ser Gln Cys Ser Glu Leu Glu Asp Leu Thr Ala Asn Thr Asn Thr
            1300                1305                1310        
Gln Asp Pro Phe Leu Ile Gly Ser Ser Lys Gln Met Arg His Gln Ser
        1315                1320                1325            
Glu Ser Gln Gly Val Gly Leu Ser Asp Lys Glu Leu Val Ser Asp Asp
    1330                1335                1340                
Glu Glu Arg Gly Thr Gly Leu Glu Glu Asn Asn Gln Glu Glu Gln Ser
1345                1350                1355                1360
Met Asp Ser Asn Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr
                1365                1370                1375    
Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu
            1380                1385                1390        
Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu Gln
        1395                1400                1405            
Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln
    1410                1415                1420                
Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu
1425                1430                1435                1440
Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Ala Val Leu Thr
                1445                1450                1455    
Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu
            1460                1465                1470        
Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn
        1475                1480                1485            
Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu
    1490                1495                1500                
Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg
1505                1510                1515                1520
Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu
                1525                1530                1535    
Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr
            1540                1545                1550        
Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile
        1555                1560                1565            
Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala
    1570                1575                1580                
Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu
1585                1590                1595                1600
Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala
                1605                1610                1615    
Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val
            1620                1625                1630        
Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys
        1635                1640                1645            
Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu
    1650                1655                1660                
Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile
1665                1670                1675                1680
Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val
                1685                1690                1695    
Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp
            1700                1705                1710        
Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met
        1715                1720                1725            
Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg
    1730                1735                1740                
Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile
1745                1750                1755                1760
Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro
                1765                1770                1775    
Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val
            1780                1785                1790        
Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile Val
        1795                1800                1805            
Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile
    1810                1815                1820                
Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu Asp
1825                1830                1835                1840
Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro
                1845                1850                1855    
Gln Ile Pro His Ser His Tyr
            1860            


<210> 8181
<211> 1598
<212> PRT
<213> Homo sapiens

<400> 8181
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn
 1               5                  10                  15      
Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys
            20                  25                  30          
Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met
        35                  40                  45              
Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys
    50                  55                  60                  
Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser
65                  70                  75                  80  
Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp
                85                  90                  95      
Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn
            100                 105                 110         
Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met
        115                 120                 125             
Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn
    130                 135                 140                 
Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly
145                 150                 155                 160 
Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr
                165                 170                 175     
Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn
            180                 185                 190         
Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr
        195                 200                 205             
Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala
    210                 215                 220                 
Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln
225                 230                 235                 240 
Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg
                245                 250                 255     
His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu
            260                 265                 270         
Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser
        275                 280                 285             
Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe
    290                 295                 300                 
Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg
305                 310                 315                 320 
Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr
                325                 330                 335     
Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu
            340                 345                 350         
Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu
        355                 360                 365             
Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu
    370                 375                 380                 
Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp
385                 390                 395                 400 
Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu
                405                 410                 415     
Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu
            420                 425                 430         
Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His
        435                 440                 445             
Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr
    450                 455                 460                 
Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn
465                 470                 475                 480 
Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg
                485                 490                 495     
Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu
            500                 505                 510         
His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr
        515                 520                 525             
Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln
    530                 535                 540                 
Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp
545                 550                 555                 560 
Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys
                565                 570                 575     
Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser
            580                 585                 590         
Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys
        595                 600                 605             
Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu
    610                 615                 620                 
Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln
625                 630                 635                 640 
Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn
                645                 650                 655     
Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys
            660                 665                 670         
Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr
        675                 680                 685             
Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn
    690                 695                 700                 
Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu
705                 710                 715                 720 
Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu
                725                 730                 735     
Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu
            740                 745                 750         
Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser
        755                 760                 765             
Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser
    770                 775                 780                 
Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys
785                 790                 795                 800 
Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His
                805                 810                 815     
Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro
            820                 825                 830         
Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu
        835                 840                 845             
Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser
    850                 855                 860                 
Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu
865                 870                 875                 880 
Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser
                885                 890                 895     
Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys
            900                 905                 910         
Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly
        915                 920                 925             
Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys
    930                 935                 940                 
Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly
945                 950                 955                 960 
Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn
                965                 970                 975     
Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr
            980                 985                 990         
Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met
        995                 1000                1005            
Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val Ser
    1010                1015                1020                
Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala Ser
1025                1030                1035                1040
Ser Ser Asn Ile Asn Glu Val Gly Ser Ser Thr Asn Glu Val Gly Ser
                1045                1050                1055    
Ser Ile Asn Glu Ile Gly Ser Ser Asp Glu Asn Ile Gln Ala Glu Leu
            1060                1065                1070        
Gly Arg Asn Arg Gly Pro Lys Leu Asn Ala Met Leu Arg Leu Gly Val
        1075                1080                1085            
Leu Gln Pro Glu Val Tyr Lys Gln Ser Leu Pro Gly Ser Asn Cys Lys
    1090                1095                1100                
His Pro Glu Ile Lys Lys Gln Glu Tyr Glu Glu Val Val Gln Thr Val
1105                1110                1115                1120
Asn Thr Asp Phe Ser Pro Tyr Leu Ile Ser Asp Asn Leu Glu Gln Pro
                1125                1130                1135    
Met Gly Ser Ser His Ala Ser Gln Val Cys Ser Glu Thr Pro Asp Asp
            1140                1145                1150        
Leu Leu Asp Asp Gly Glu Ile Lys Glu Asp Thr Ser Phe Ala Glu Asn
        1155                1160                1165            
Asp Ile Lys Glu Ser Ser Ala Val Phe Ser Lys Ser Val Gln Lys Gly
    1170                1175                1180                
Glu Leu Ser Arg Ser Pro Ser Pro Phe Thr His Thr His Leu Ala Gln
1185                1190                1195                1200
Gly Tyr Arg Arg Gly Ala Lys Lys Leu Glu Ser Ser Glu Glu Asn Leu
                1205                1210                1215    
Ser Ser Glu Asp Glu Glu Leu Pro Cys Phe Gln His Leu Leu Phe Gly
            1220                1225                1230        
Lys Val Asn Asn Ile Pro Ser Gln Ser Thr Arg His Ser Thr Val Ala
        1235                1240                1245            
Thr Glu Cys Leu Ser Lys Asn Thr Glu Glu Asn Leu Leu Ser Leu Lys
    1250                1255                1260                
Asn Ser Leu Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys Ala Ser
1265                1270                1275                1280
Gln Glu His His Leu Ser Glu Glu Thr Lys Cys Ser Ala Ser Leu Phe
                1285                1290                1295    
Ser Ser Gln Cys Ser Glu Leu Glu Asp Leu Thr Ala Asn Thr Asn Thr
            1300                1305                1310        
Gln Asp Pro Phe Leu Ile Gly Ser Ser Lys Gln Met Arg His Gln Ser
        1315                1320                1325            
Glu Ser Gln Gly Val Gly Leu Ser Asp Lys Glu Leu Val Ser Asp Asp
    1330                1335                1340                
Glu Glu Arg Gly Thr Gly Leu Glu Glu Asn Asn Gln Glu Glu Gln Ser
1345                1350                1355                1360
Met Asp Ser Asn Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr
                1365                1370                1375    
Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu
            1380                1385                1390        
Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu Gln
        1395                1400                1405            
Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln
    1410                1415                1420                
Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu
1425                1430                1435                1440
Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Gly Val Thr Gln
                1445                1450                1455    
Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe Glu Val Arg
            1460                1465                1470        
Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys Arg Ala Arg
        1475                1480                1485            
Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile Cys Cys Tyr
    1490                1495                1500                
Gly Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu Trp Met Val Gln
1505                1510                1515                1520
Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe Thr Leu Gly
                1525                1530                1535    
Thr Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp Thr Glu
            1540                1545                1550        
Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro Val Val
        1555                1560                1565            
Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys Gln Glu
    1570                1575                1580                
Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr
1585                1590                1595            


<210> 8182
<211> 1567
<212> PRT
<213> Homo sapiens

<400> 8182
Met Asn Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly
 1               5                  10                  15      
Leu Ala Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu Thr Cys
            20                  25                  30          
Asn Asp Arg Arg Thr Pro Ser Thr Glu Lys Lys Val Asp Leu Asn Ala
        35                  40                  45              
Asp Pro Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys
    50                  55                  60                  
Ser Glu Asn Pro Arg Asp Thr Glu Asp Val Pro Trp Ile Thr Leu Asn
65                  70                  75                  80  
Ser Ser Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu
                85                  90                  95      
Leu Gly Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys
            100                 105                 110         
Val Ala Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly
        115                 120                 125             
Ser Ser Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu
    130                 135                 140                 
Ile Cys Lys Ser Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile
145                 150                 155                 160 
Glu Asp Lys Ile Phe Gly Lys Thr Tyr Arg Lys Lys Ala Ser Leu Pro
                165                 170                 175     
Asn Leu Ser His Val Thr Glu Asn Leu Ile Ile Gly Ala Phe Val Thr
            180                 185                 190         
Glu Pro Gln Ile Ile Gln Glu Arg Pro Leu Thr Asn Lys Leu Lys Arg
        195                 200                 205             
Lys Arg Arg Pro Thr Ser Gly Leu His Pro Glu Asp Phe Ile Lys Lys
    210                 215                 220                 
Ala Asp Leu Ala Val Gln Lys Thr Pro Glu Met Ile Asn Gln Gly Thr
225                 230                 235                 240 
Asn Gln Thr Glu Gln Asn Gly Gln Val Met Asn Ile Thr Asn Ser Gly
                245                 250                 255     
His Glu Asn Lys Thr Lys Gly Asp Ser Ile Gln Asn Glu Lys Asn Pro
            260                 265                 270         
Asn Pro Ile Glu Ser Leu Glu Lys Glu Ser Ala Phe Lys Thr Lys Ala
        275                 280                 285             
Glu Pro Ile Ser Ser Ser Ile Ser Asn Met Glu Leu Glu Leu Asn Ile
    290                 295                 300                 
His Asn Ser Lys Ala Pro Lys Lys Asn Arg Leu Arg Arg Lys Ser Ser
305                 310                 315                 320 
Thr Arg His Ile His Ala Leu Glu Leu Val Val Ser Arg Asn Leu Ser
                325                 330                 335     
Pro Pro Asn Cys Thr Glu Leu Gln Ile Asp Ser Cys Ser Ser Ser Glu
            340                 345                 350         
Glu Ile Lys Lys Lys Lys Tyr Asn Gln Met Pro Val Arg His Ser Arg
        355                 360                 365             
Asn Leu Gln Leu Met Glu Gly Lys Glu Pro Ala Thr Gly Ala Lys Lys
    370                 375                 380                 
Ser Asn Lys Pro Asn Glu Gln Thr Ser Lys Arg His Asp Ser Asp Thr
385                 390                 395                 400 
Phe Pro Glu Leu Lys Leu Thr Asn Ala Pro Gly Ser Phe Thr Lys Cys
                405                 410                 415     
Ser Asn Thr Ser Glu Leu Lys Glu Phe Val Asn Pro Ser Leu Pro Arg
            420                 425                 430         
Glu Glu Lys Glu Glu Lys Leu Glu Thr Val Lys Val Ser Asn Asn Ala
        435                 440                 445             
Glu Asp Pro Lys Asp Leu Met Leu Ser Gly Glu Arg Val Leu Gln Thr
    450                 455                 460                 
Glu Arg Ser Val Glu Ser Ser Ser Ile Ser Leu Val Pro Gly Thr Asp
465                 470                 475                 480 
Tyr Gly Thr Gln Glu Ser Ile Ser Leu Leu Glu Val Ser Thr Leu Gly
                485                 490                 495     
Lys Ala Lys Thr Glu Pro Asn Lys Cys Val Ser Gln Cys Ala Ala Phe
            500                 505                 510         
Glu Asn Pro Lys Gly Leu Ile His Gly Cys Ser Lys Asp Asn Arg Asn
        515                 520                 525             
Asp Thr Glu Gly Phe Lys Tyr Pro Leu Gly His Glu Val Asn His Ser
    530                 535                 540                 
Arg Glu Thr Ser Ile Glu Met Glu Glu Ser Glu Leu Asp Ala Gln Tyr
545                 550                 555                 560 
Leu Gln Asn Thr Phe Lys Val Ser Lys Arg Gln Ser Phe Ala Pro Phe
                565                 570                 575     
Ser Asn Pro Gly Asn Ala Glu Glu Glu Cys Ala Thr Phe Ser Ala His
            580                 585                 590         
Ser Gly Ser Leu Lys Lys Gln Ser Pro Lys Val Thr Phe Glu Cys Glu
        595                 600                 605             
Gln Lys Glu Glu Asn Gln Gly Lys Asn Glu Ser Asn Ile Lys Pro Val
    610                 615                 620                 
Gln Thr Val Asn Ile Thr Ala Gly Phe Pro Val Val Gly Gln Lys Asp
625                 630                 635                 640 
Lys Pro Val Asp Asn Ala Lys Cys Ser Ile Lys Gly Gly Ser Arg Phe
                645                 650                 655     
Cys Leu Ser Ser Gln Phe Arg Gly Asn Glu Thr Gly Leu Ile Thr Pro
            660                 665                 670         
Asn Lys His Gly Leu Leu Gln Asn Pro Tyr Arg Ile Pro Pro Leu Phe
        675                 680                 685             
Pro Ile Lys Ser Phe Val Lys Thr Lys Cys Lys Lys Asn Leu Leu Glu
    690                 695                 700                 
Glu Asn Phe Glu Glu His Ser Met Ser Pro Glu Arg Glu Met Gly Asn
705                 710                 715                 720 
Glu Asn Ile Pro Ser Thr Val Ser Thr Ile Ser Arg Asn Asn Ile Arg
                725                 730                 735     
Glu Asn Val Phe Lys Glu Ala Ser Ser Ser Asn Ile Asn Glu Val Gly
            740                 745                 750         
Ser Ser Thr Asn Glu Val Gly Ser Ser Ile Asn Glu Ile Gly Ser Ser
        755                 760                 765             
Asp Glu Asn Ile Gln Ala Glu Leu Gly Arg Asn Arg Gly Pro Lys Leu
    770                 775                 780                 
Asn Ala Met Leu Arg Leu Gly Val Leu Gln Pro Glu Val Tyr Lys Gln
785                 790                 795                 800 
Ser Leu Pro Gly Ser Asn Cys Lys His Pro Glu Ile Lys Lys Gln Glu
                805                 810                 815     
Tyr Glu Glu Val Val Gln Thr Val Asn Thr Asp Phe Ser Pro Tyr Leu
            820                 825                 830         
Ile Ser Asp Asn Leu Glu Gln Pro Met Gly Ser Ser His Ala Ser Gln
        835                 840                 845             
Val Cys Ser Glu Thr Pro Asp Asp Leu Leu Asp Asp Gly Glu Ile Lys
    850                 855                 860                 
Glu Asp Thr Ser Phe Ala Glu Asn Asp Ile Lys Glu Ser Ser Ala Val
865                 870                 875                 880 
Phe Ser Lys Ser Val Gln Lys Gly Glu Leu Ser Arg Ser Pro Ser Pro
                885                 890                 895     
Phe Thr His Thr His Leu Ala Gln Gly Tyr Arg Arg Gly Ala Lys Lys
            900                 905                 910         
Leu Glu Ser Ser Glu Glu Asn Leu Ser Ser Glu Asp Glu Glu Leu Pro
        915                 920                 925             
Cys Phe Gln His Leu Leu Phe Gly Lys Val Asn Asn Ile Pro Ser Gln
    930                 935                 940                 
Ser Thr Arg His Ser Thr Val Ala Thr Glu Cys Leu Ser Lys Asn Thr
945                 950                 955                 960 
Glu Glu Asn Leu Leu Ser Leu Lys Asn Ser Leu Asn Asp Cys Ser Asn
                965                 970                 975     
Gln Val Ile Leu Ala Lys Ala Ser Gln Glu His His Leu Ser Glu Glu
            980                 985                 990         
Thr Lys Cys Ser Ala Ser Leu Phe Ser Ser Gln Cys Ser Glu Leu Glu
        995                 1000                1005            
Asp Leu Thr Ala Asn Thr Asn Thr Gln Asp Pro Phe Leu Ile Gly Ser
    1010                1015                1020                
Ser Lys Gln Met Arg His Gln Ser Glu Ser Gln Gly Val Gly Leu Ser
1025                1030                1035                1040
Asp Lys Glu Leu Val Ser Asp Asp Glu Glu Arg Gly Thr Gly Leu Glu
                1045                1050                1055    
Glu Asn Asn Gln Glu Glu Gln Ser Met Asp Ser Asn Leu Gly Glu Ala
            1060                1065                1070        
Ala Ser Gly Cys Glu Ser Glu Thr Ser Val Ser Glu Asp Cys Ser Gly
        1075                1080                1085            
Leu Ser Ser Gln Ser Asp Ile Leu Thr Thr Gln Gln Arg Asp Thr Met
    1090                1095                1100                
Gln His Asn Leu Ile Lys Leu Gln Gln Glu Met Ala Glu Leu Glu Ala
1105                1110                1115                1120
Val Leu Glu Gln His Gly Ser Gln Pro Ser Asn Ser Tyr Pro Ser Ile
                1125                1130                1135    
Ile Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg Asn Pro Glu Gln Ser
            1140                1145                1150        
Thr Ser Glu Lys Ala Val Leu Thr Ser Gln Lys Ser Ser Glu Tyr Pro
        1155                1160                1165            
Ile Ser Gln Asn Pro Glu Gly Leu Ser Ala Asp Lys Phe Glu Val Ser
    1170                1175                1180                
Ala Asp Ser Ser Thr Ser Lys Asn Lys Glu Pro Gly Val Glu Arg Ser
1185                1190                1195                1200
Ser Pro Ser Lys Cys Pro Ser Leu Asp Asp Arg Trp Tyr Met His Ser
                1205                1210                1215    
Cys Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln Glu Glu Leu
            1220                1225                1230        
Ile Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu Ser Gly Pro
        1235                1240                1245            
His Asp Leu Thr Glu Thr Ser Tyr Leu Pro Arg Gln Asp Leu Glu Gly
    1250                1255                1260                
Thr Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp Asp Pro Glu
1265                1270                1275                1280
Ser Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg Val Gly Asn
                1285                1290                1295    
Ile Pro Ser Ser Thr Ser Ala Leu Lys Val Pro Gln Leu Lys Val Ala
            1300                1305                1310        
Glu Ser Ala Gln Ser Pro Ala Ala Ala His Thr Thr Asp Thr Ala Gly
        1315                1320                1325            
Tyr Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro Glu Leu Thr
    1330                1335                1340                
Ala Ser Thr Glu Arg Val Asn Lys Arg Met Ser Met Val Val Ser Gly
1345                1350                1355                1360
Leu Thr Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala Arg Lys His
                1365                1370                1375    
His Ile Thr Leu Thr Asn Leu Ile Thr Glu Glu Thr Thr His Val Val
            1380                1385                1390        
Met Lys Thr Asp Ala Glu Phe Val Cys Glu Arg Thr Leu Lys Tyr Phe
        1395                1400                1405            
Leu Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp Val Thr
    1410                1415                1420                
Gln Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe Glu Val
1425                1430                1435                1440
Arg Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys Arg Ala
                1445                1450                1455    
Arg Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile Cys Cys
            1460                1465                1470        
Tyr Gly Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu Trp Met Val
        1475                1480                1485            
Gln Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe Thr Leu
    1490                1495                1500                
Gly Thr Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp Thr
1505                1510                1515                1520
Glu Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro Val
                1525                1530                1535    
Val Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys Gln
            1540                1545                1550        
Glu Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr
        1555                1560                1565        


<210> 8183
<211> 1822
<212> PRT
<213> Homo sapiens

<400> 8183
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn
 1               5                  10                  15      
Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys
            20                  25                  30          
Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met
        35                  40                  45              
Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys
    50                  55                  60                  
Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser
65                  70                  75                  80  
Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp
                85                  90                  95      
Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn
            100                 105                 110         
Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met
        115                 120                 125             
Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn
    130                 135                 140                 
Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly
145                 150                 155                 160 
Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr
                165                 170                 175     
Ser Val Tyr Ile Glu Leu Ala Ala Cys Glu Phe Ser Glu Thr Asp Val
            180                 185                 190         
Thr Asn Thr Glu His His Gln Pro Ser Asn Asn Asp Leu Asn Thr Thr
        195                 200                 205             
Glu Lys Arg Ala Ala Glu Arg His Pro Glu Lys Tyr Gln Gly Ser Ser
    210                 215                 220                 
Val Ser Asn Leu His Val Glu Pro Cys Gly Thr Asn Thr His Ala Ser
225                 230                 235                 240 
Ser Leu Gln His Glu Asn Ser Ser Leu Leu Leu Thr Lys Asp Arg Met
                245                 250                 255     
Asn Val Glu Lys Ala Glu Phe Cys Asn Lys Ser Lys Gln Pro Gly Leu
            260                 265                 270         
Ala Arg Ser Gln His Asn Arg Trp Ala Gly Ser Lys Glu Thr Cys Asn
        275                 280                 285             
Asp Arg Arg Thr Pro Ser Thr Glu Lys Lys Val Asp Leu Asn Ala Asp
    290                 295                 300                 
Pro Leu Cys Glu Arg Lys Glu Trp Asn Lys Gln Lys Leu Pro Cys Ser
305                 310                 315                 320 
Glu Asn Pro Arg Asp Thr Glu Asp Val Pro Trp Ile Thr Leu Asn Ser
                325                 330                 335     
Ser Ile Gln Lys Val Asn Glu Trp Phe Ser Arg Ser Asp Glu Leu Leu
            340                 345                 350         
Gly Ser Asp Asp Ser His Asp Gly Glu Ser Glu Ser Asn Ala Lys Val
        355                 360                 365             
Ala Asp Val Leu Asp Val Leu Asn Glu Val Asp Glu Tyr Ser Gly Ser
    370                 375                 380                 
Ser Glu Lys Ile Asp Leu Leu Ala Ser Asp Pro His Glu Ala Leu Ile
385                 390                 395                 400 
Cys Lys Ser Glu Arg Val His Ser Lys Ser Val Glu Ser Asn Ile Glu
                405                 410                 415     
Asp Lys Ile Phe Gly Lys Thr Tyr Arg Lys Lys Ala Ser Leu Pro Asn
            420                 425                 430         
Leu Ser His Val Thr Glu Asn Leu Ile Ile Gly Ala Phe Val Thr Glu
        435                 440                 445             
Pro Gln Ile Ile Gln Glu Arg Pro Leu Thr Asn Lys Leu Lys Arg Lys
    450                 455                 460                 
Arg Arg Pro Thr Ser Gly Leu His Pro Glu Asp Phe Ile Lys Lys Ala
465                 470                 475                 480 
Asp Leu Ala Val Gln Lys Thr Pro Glu Met Ile Asn Gln Gly Thr Asn
                485                 490                 495     
Gln Thr Glu Gln Asn Gly Gln Val Met Asn Ile Thr Asn Ser Gly His
            500                 505                 510         
Glu Asn Lys Thr Lys Gly Asp Ser Ile Gln Asn Glu Lys Asn Pro Asn
        515                 520                 525             
Pro Ile Glu Ser Leu Glu Lys Glu Ser Ala Phe Lys Thr Lys Ala Glu
    530                 535                 540                 
Pro Ile Ser Ser Ser Ile Ser Asn Met Glu Leu Glu Leu Asn Ile His
545                 550                 555                 560 
Asn Ser Lys Ala Pro Lys Lys Asn Arg Leu Arg Arg Lys Ser Ser Thr
                565                 570                 575     
Arg His Ile His Ala Leu Glu Leu Val Val Ser Arg Asn Leu Ser Pro
            580                 585                 590         
Pro Asn Cys Thr Glu Leu Gln Ile Asp Ser Cys Ser Ser Ser Glu Glu
        595                 600                 605             
Ile Lys Lys Lys Lys Tyr Asn Gln Met Pro Val Arg His Ser Arg Asn
    610                 615                 620                 
Leu Gln Leu Met Glu Gly Lys Glu Pro Ala Thr Gly Ala Lys Lys Ser
625                 630                 635                 640 
Asn Lys Pro Asn Glu Gln Thr Ser Lys Arg His Asp Ser Asp Thr Phe
                645                 650                 655     
Pro Glu Leu Lys Leu Thr Asn Ala Pro Gly Ser Phe Thr Lys Cys Ser
            660                 665                 670         
Asn Thr Ser Glu Leu Lys Glu Phe Val Asn Pro Ser Leu Pro Arg Glu
        675                 680                 685             
Glu Lys Glu Glu Lys Leu Glu Thr Val Lys Val Ser Asn Asn Ala Glu
    690                 695                 700                 
Asp Pro Lys Asp Leu Met Leu Ser Gly Glu Arg Val Leu Gln Thr Glu
705                 710                 715                 720 
Arg Ser Val Glu Ser Ser Ser Ile Ser Leu Val Pro Gly Thr Asp Tyr
                725                 730                 735     
Gly Thr Gln Glu Ser Ile Ser Leu Leu Glu Val Ser Thr Leu Gly Lys
            740                 745                 750         
Ala Lys Thr Glu Pro Asn Lys Cys Val Ser Gln Cys Ala Ala Phe Glu
        755                 760                 765             
Asn Pro Lys Gly Leu Ile His Gly Cys Ser Lys Asp Asn Arg Asn Asp
    770                 775                 780                 
Thr Glu Gly Phe Lys Tyr Pro Leu Gly His Glu Val Asn His Ser Arg
785                 790                 795                 800 
Glu Thr Ser Ile Glu Met Glu Glu Ser Glu Leu Asp Ala Gln Tyr Leu
                805                 810                 815     
Gln Asn Thr Phe Lys Val Ser Lys Arg Gln Ser Phe Ala Pro Phe Ser
            820                 825                 830         
Asn Pro Gly Asn Ala Glu Glu Glu Cys Ala Thr Phe Ser Ala His Ser
        835                 840                 845             
Gly Ser Leu Lys Lys Gln Ser Pro Lys Val Thr Phe Glu Cys Glu Gln
    850                 855                 860                 
Lys Glu Glu Asn Gln Gly Lys Asn Glu Ser Asn Ile Lys Pro Val Gln
865                 870                 875                 880 
Thr Val Asn Ile Thr Ala Gly Phe Pro Val Val Gly Gln Lys Asp Lys
                885                 890                 895     
Pro Val Asp Asn Ala Lys Cys Ser Ile Lys Gly Gly Ser Arg Phe Cys
            900                 905                 910         
Leu Ser Ser Gln Phe Arg Gly Asn Glu Thr Gly Leu Ile Thr Pro Asn
        915                 920                 925             
Lys His Gly Leu Leu Gln Asn Pro Tyr Arg Ile Pro Pro Leu Phe Pro
    930                 935                 940                 
Ile Lys Ser Phe Val Lys Thr Lys Cys Lys Lys Asn Leu Leu Glu Glu
945                 950                 955                 960 
Asn Phe Glu Glu His Ser Met Ser Pro Glu Arg Glu Met Gly Asn Glu
                965                 970                 975     
Asn Ile Pro Ser Thr Val Ser Thr Ile Ser Arg Asn Asn Ile Arg Glu
            980                 985                 990         
Asn Val Phe Lys Glu Ala Ser Ser Ser Asn Ile Asn Glu Val Gly Ser
        995                 1000                1005            
Ser Thr Asn Glu Val Gly Ser Ser Ile Asn Glu Ile Gly Ser Ser Asp
    1010                1015                1020                
Glu Asn Ile Gln Ala Glu Leu Gly Arg Asn Arg Gly Pro Lys Leu Asn
1025                1030                1035                1040
Ala Met Leu Arg Leu Gly Val Leu Gln Pro Glu Val Tyr Lys Gln Ser
                1045                1050                1055    
Leu Pro Gly Ser Asn Cys Lys His Pro Glu Ile Lys Lys Gln Glu Tyr
            1060                1065                1070        
Glu Glu Val Val Gln Thr Val Asn Thr Asp Phe Ser Pro Tyr Leu Ile
        1075                1080                1085            
Ser Asp Asn Leu Glu Gln Pro Met Gly Ser Ser His Ala Ser Gln Val
    1090                1095                1100                
Cys Ser Glu Thr Pro Asp Asp Leu Leu Asp Asp Gly Glu Ile Lys Glu
1105                1110                1115                1120
Asp Thr Ser Phe Ala Glu Asn Asp Ile Lys Glu Ser Ser Ala Val Phe
                1125                1130                1135    
Ser Lys Ser Val Gln Lys Gly Glu Leu Ser Arg Ser Pro Ser Pro Phe
            1140                1145                1150        
Thr His Thr His Leu Ala Gln Gly Tyr Arg Arg Gly Ala Lys Lys Leu
        1155                1160                1165            
Glu Ser Ser Glu Glu Asn Leu Ser Ser Glu Asp Glu Glu Leu Pro Cys
    1170                1175                1180                
Phe Gln His Leu Leu Phe Gly Lys Val Asn Asn Ile Pro Ser Gln Ser
1185                1190                1195                1200
Thr Arg His Ser Thr Val Ala Thr Glu Cys Leu Ser Lys Asn Thr Glu
                1205                1210                1215    
Glu Asn Leu Leu Ser Leu Lys Asn Ser Leu Asn Asp Cys Ser Asn Gln
            1220                1225                1230        
Val Ile Leu Ala Lys Ala Ser Gln Glu His His Leu Ser Glu Glu Thr
        1235                1240                1245            
Lys Cys Ser Ala Ser Leu Phe Ser Ser Gln Cys Ser Glu Leu Glu Asp
    1250                1255                1260                
Leu Thr Ala Asn Thr Asn Thr Gln Asp Pro Phe Leu Ile Gly Ser Ser
1265                1270                1275                1280
Lys Gln Met Arg His Gln Ser Glu Ser Gln Gly Val Gly Leu Ser Asp
                1285                1290                1295    
Lys Glu Leu Val Ser Asp Asp Glu Glu Arg Gly Thr Gly Leu Glu Glu
            1300                1305                1310        
Asn Asn Gln Glu Glu Gln Ser Met Asp Ser Asn Leu Gly Glu Ala Ala
        1315                1320                1325            
Ser Gly Cys Glu Ser Glu Thr Ser Val Ser Glu Asp Cys Ser Gly Leu
    1330                1335                1340                
Ser Ser Gln Ser Asp Ile Leu Thr Thr Gln Gln Arg Asp Thr Met Gln
1345                1350                1355                1360
His Asn Leu Ile Lys Leu Gln Gln Glu Met Ala Glu Leu Glu Ala Val
                1365                1370                1375    
Leu Glu Gln His Gly Ser Gln Pro Ser Asn Ser Tyr Pro Ser Ile Ile
            1380                1385                1390        
Ser Asp Ser Ser Ala Leu Glu Asp Leu Arg Asn Pro Glu Gln Ser Thr
        1395                1400                1405            
Ser Glu Lys Ala Val Leu Thr Ser Gln Lys Ser Ser Glu Tyr Pro Ile
    1410                1415                1420                
Ser Gln Asn Pro Glu Gly Leu Ser Ala Asp Lys Phe Glu Val Ser Ala
1425                1430                1435                1440
Asp Ser Ser Thr Ser Lys Asn Lys Glu Pro Gly Val Glu Arg Ser Ser
                1445                1450                1455    
Pro Ser Lys Cys Pro Ser Leu Asp Asp Arg Trp Tyr Met His Ser Cys
            1460                1465                1470        
Ser Gly Ser Leu Gln Asn Arg Asn Tyr Pro Ser Gln Glu Glu Leu Ile
        1475                1480                1485            
Lys Val Val Asp Val Glu Glu Gln Gln Leu Glu Glu Ser Gly Pro His
    1490                1495                1500                
Asp Leu Thr Glu Thr Ser Tyr Leu Pro Arg Gln Asp Leu Glu Gly Thr
1505                1510                1515                1520
Pro Tyr Leu Glu Ser Gly Ile Ser Leu Phe Ser Asp Asp Pro Glu Ser
                1525                1530                1535    
Asp Pro Ser Glu Asp Arg Ala Pro Glu Ser Ala Arg Val Gly Asn Ile
            1540                1545                1550        
Pro Ser Ser Thr Ser Ala Leu Lys Val Pro Gln Leu Lys Val Ala Glu
        1555                1560                1565            
Ser Ala Gln Ser Pro Ala Ala Ala His Thr Thr Asp Thr Ala Gly Tyr
    1570                1575                1580                
Asn Ala Met Glu Glu Ser Val Ser Arg Glu Lys Pro Glu Leu Thr Ala
1585                1590                1595                1600
Ser Thr Glu Arg Val Asn Lys Arg Met Ser Met Val Val Ser Gly Leu
                1605                1610                1615    
Thr Pro Glu Glu Phe Met Leu Val Tyr Lys Phe Ala Arg Lys His His
            1620                1625                1630        
Ile Thr Leu Thr Asn Leu Ile Thr Glu Glu Thr Thr His Val Val Met
        1635                1640                1645            
Lys Thr Asp Ala Glu Phe Val Cys Glu Arg Thr Leu Lys Tyr Phe Leu
    1650                1655                1660                
Gly Ile Ala Gly Gly Lys Trp Val Val Ser Tyr Phe Trp Val Thr Gln
1665                1670                1675                1680
Ser Ile Lys Glu Arg Lys Met Leu Asn Glu His Asp Phe Glu Val Arg
                1685                1690                1695    
Gly Asp Val Val Asn Gly Arg Asn His Gln Gly Pro Lys Arg Ala Arg
            1700                1705                1710        
Glu Ser Gln Asp Arg Lys Ile Phe Arg Gly Leu Glu Ile Cys Cys Tyr
        1715                1720                1725            
Gly Pro Phe Thr Asn Met Pro Thr Asp Gln Leu Glu Trp Met Val Gln
    1730                1735                1740                
Leu Cys Gly Ala Ser Val Val Lys Glu Leu Ser Ser Phe Thr Leu Gly
1745                1750                1755                1760
Thr Gly Val His Pro Ile Val Val Val Gln Pro Asp Ala Trp Thr Glu
                1765                1770                1775    
Asp Asn Gly Phe His Ala Ile Gly Gln Met Cys Glu Ala Pro Val Val
            1780                1785                1790        
Thr Arg Glu Trp Val Leu Asp Ser Val Ala Leu Tyr Gln Cys Gln Glu
        1795                1800                1805            
Leu Asp Thr Tyr Leu Ile Pro Gln Ile Pro His Ser His Tyr
    1810                1815                1820        


<210> 8184
<211> 1624
<212> PRT
<213> Homo sapiens

<400> 8184
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn
 1               5                  10                  15      
Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys
            20                  25                  30          
Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met
        35                  40                  45              
Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys
    50                  55                  60                  
Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser
65                  70                  75                  80  
Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp
                85                  90                  95      
Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn
            100                 105                 110         
Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met
        115                 120                 125             
Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn
    130                 135                 140                 
Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly
145                 150                 155                 160 
Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr
                165                 170                 175     
Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn
            180                 185                 190         
Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr
        195                 200                 205             
Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala
    210                 215                 220                 
Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln
225                 230                 235                 240 
Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg
                245                 250                 255     
His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu
            260                 265                 270         
Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser
        275                 280                 285             
Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe
    290                 295                 300                 
Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg
305                 310                 315                 320 
Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr
                325                 330                 335     
Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu
            340                 345                 350         
Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu
        355                 360                 365             
Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu
    370                 375                 380                 
Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp
385                 390                 395                 400 
Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu
                405                 410                 415     
Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu
            420                 425                 430         
Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His
        435                 440                 445             
Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr
    450                 455                 460                 
Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn
465                 470                 475                 480 
Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg
                485                 490                 495     
Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu
            500                 505                 510         
His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr
        515                 520                 525             
Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln
    530                 535                 540                 
Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp
545                 550                 555                 560 
Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys
                565                 570                 575     
Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser
            580                 585                 590         
Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys
        595                 600                 605             
Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu
    610                 615                 620                 
Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln
625                 630                 635                 640 
Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn
                645                 650                 655     
Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys
            660                 665                 670         
Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr
        675                 680                 685             
Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn
    690                 695                 700                 
Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu
705                 710                 715                 720 
Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu
                725                 730                 735     
Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu
            740                 745                 750         
Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser
        755                 760                 765             
Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser
    770                 775                 780                 
Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys
785                 790                 795                 800 
Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His
                805                 810                 815     
Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro
            820                 825                 830         
Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu
        835                 840                 845             
Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser
    850                 855                 860                 
Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu
865                 870                 875                 880 
Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser
                885                 890                 895     
Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys
            900                 905                 910         
Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly
        915                 920                 925             
Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys
    930                 935                 940                 
Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly
945                 950                 955                 960 
Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn
                965                 970                 975     
Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr
            980                 985                 990         
Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met
        995                 1000                1005            
Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val Ser
    1010                1015                1020                
Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala Ser
1025                1030                1035                1040
Ser Ser Asn Ile Asn Glu Val Gly Ser Ser Thr Asn Glu Val Gly Ser
                1045                1050                1055    
Ser Ile Asn Glu Ile Gly Ser Ser Asp Glu Asn Ile Gln Ala Glu Leu
            1060                1065                1070        
Gly Arg Asn Arg Gly Pro Lys Leu Asn Ala Met Leu Arg Leu Gly Val
        1075                1080                1085            
Leu Gln Pro Glu Val Tyr Lys Gln Ser Leu Pro Gly Ser Asn Cys Lys
    1090                1095                1100                
His Pro Glu Ile Lys Lys Gln Glu Tyr Glu Glu Val Val Gln Thr Val
1105                1110                1115                1120
Asn Thr Asp Phe Ser Pro Tyr Leu Ile Ser Asp Asn Leu Glu Gln Pro
                1125                1130                1135    
Met Gly Ser Ser His Ala Ser Gln Val Cys Ser Glu Thr Pro Asp Asp
            1140                1145                1150        
Leu Leu Asp Asp Gly Glu Ile Lys Glu Asp Thr Ser Phe Ala Glu Asn
        1155                1160                1165            
Asp Ile Lys Glu Ser Ser Ala Val Phe Ser Lys Ser Val Gln Lys Gly
    1170                1175                1180                
Glu Leu Ser Arg Ser Pro Ser Pro Phe Thr His Thr His Leu Ala Gln
1185                1190                1195                1200
Gly Tyr Arg Arg Gly Ala Lys Lys Leu Glu Ser Ser Glu Glu Asn Leu
                1205                1210                1215    
Ser Ser Glu Asp Glu Glu Leu Pro Cys Phe Gln His Leu Leu Phe Gly
            1220                1225                1230        
Lys Val Asn Asn Ile Pro Ser Gln Ser Thr Arg His Ser Thr Val Ala
        1235                1240                1245            
Thr Glu Cys Leu Ser Lys Asn Thr Glu Glu Asn Leu Leu Ser Leu Lys
    1250                1255                1260                
Asn Ser Leu Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys Ala Ser
1265                1270                1275                1280
Gln Glu His His Leu Ser Glu Glu Thr Lys Cys Ser Ala Ser Leu Phe
                1285                1290                1295    
Ser Ser Gln Cys Ser Glu Leu Glu Asp Leu Thr Ala Asn Thr Asn Thr
            1300                1305                1310        
Gln Asp Pro Phe Leu Ile Gly Ser Ser Lys Gln Met Arg His Gln Ser
        1315                1320                1325            
Glu Ser Gln Gly Val Gly Leu Ser Asp Lys Glu Leu Val Ser Asp Asp
    1330                1335                1340                
Glu Glu Arg Gly Thr Gly Leu Glu Glu Asn Asn Gln Glu Glu Gln Ser
1345                1350                1355                1360
Met Asp Ser Asn Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr
                1365                1370                1375    
Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu
            1380                1385                1390        
Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu Gln
        1395                1400                1405            
Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln
    1410                1415                1420                
Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu
1425                1430                1435                1440
Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Asp Ala Glu Phe
                1445                1450                1455    
Val Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys
            1460                1465                1470        
Trp Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys
        1475                1480                1485            
Met Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly
    1490                1495                1500                
Arg Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys
1505                1510                1515                1520
Ile Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met
                1525                1530                1535    
Pro Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val
            1540                1545                1550        
Val Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile
        1555                1560                1565            
Val Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala
    1570                1575                1580                
Ile Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu
1585                1590                1595                1600
Asp Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile
                1605                1610                1615    
Pro Gln Ile Pro His Ser His Tyr
            1620                


<210> 8185
<211> 1496
<212> PRT
<213> Homo sapiens

<400> 8185
Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn
 1               5                  10                  15      
Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys
            20                  25                  30          
Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met
        35                  40                  45              
Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys
    50                  55                  60                  
Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser
65                  70                  75                  80  
Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp
                85                  90                  95      
Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn
            100                 105                 110         
Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met
        115                 120                 125             
Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn
    130                 135                 140                 
Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly
145                 150                 155                 160 
Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr
                165                 170                 175     
Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn
            180                 185                 190         
Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr
        195                 200                 205             
Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala
    210                 215                 220                 
Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln
225                 230                 235                 240 
Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg
                245                 250                 255     
His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu
            260                 265                 270         
Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser
        275                 280                 285             
Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe
    290                 295                 300                 
Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg
305                 310                 315                 320 
Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr
                325                 330                 335     
Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu
            340                 345                 350         
Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu
        355                 360                 365             
Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu
    370                 375                 380                 
Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp
385                 390                 395                 400 
Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu
                405                 410                 415     
Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu
            420                 425                 430         
Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His
        435                 440                 445             
Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr
    450                 455                 460                 
Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn
465                 470                 475                 480 
Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg
                485                 490                 495     
Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu
            500                 505                 510         
His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr
        515                 520                 525             
Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln
    530                 535                 540                 
Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp
545                 550                 555                 560 
Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys
                565                 570                 575     
Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser
            580                 585                 590         
Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys
        595                 600                 605             
Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu
    610                 615                 620                 
Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln
625                 630                 635                 640 
Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn
                645                 650                 655     
Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys
            660                 665                 670         
Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr
        675                 680                 685             
Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn
    690                 695                 700                 
Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu
705                 710                 715                 720 
Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu
                725                 730                 735     
Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu
            740                 745                 750         
Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser
        755                 760                 765             
Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser
    770                 775                 780                 
Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys
785                 790                 795                 800 
Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His
                805                 810                 815     
Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro
            820                 825                 830         
Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu
        835                 840                 845             
Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser
    850                 855                 860                 
Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu
865                 870                 875                 880 
Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser
                885                 890                 895     
Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys
            900                 905                 910         
Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly
        915                 920                 925             
Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys
    930                 935                 940                 
Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly
945                 950                 955                 960 
Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn
                965                 970                 975     
Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr
            980                 985                 990         
Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met
        995                 1000                1005            
Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val Ser
    1010                1015                1020                
Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala Ser
1025                1030                1035                1040
Ser Ser Asn Ile Asn Glu Val Gly Ser Ser Thr Asn Glu Val Gly Ser
                1045                1050                1055    
Ser Ile Asn Glu Ile Gly Ser Ser Asp Glu Asn Ile Gln Ala Glu Leu
            1060                1065                1070        
Gly Arg Asn Arg Gly Pro Lys Leu Asn Ala Met Leu Arg Leu Gly Val
        1075                1080                1085            
Leu Gln Pro Glu Val Tyr Lys Gln Ser Leu Pro Gly Ser Asn Cys Lys
    1090                1095                1100                
His Pro Glu Ile Lys Lys Gln Glu Tyr Glu Glu Val Val Gln Thr Val
1105                1110                1115                1120
Asn Thr Asp Phe Ser Pro Tyr Leu Ile Ser Asp Asn Leu Glu Gln Pro
                1125                1130                1135    
Met Gly Ser Ser His Ala Ser Gln Val Cys Ser Glu Thr Pro Asp Asp
            1140                1145                1150        
Leu Leu Asp Asp Gly Glu Ile Lys Glu Asp Thr Ser Phe Ala Glu Asn
        1155                1160                1165            
Asp Ile Lys Glu Ser Ser Ala Val Phe Ser Lys Ser Val Gln Lys Gly
    1170                1175                1180                
Glu Leu Ser Arg Ser Pro Ser Pro Phe Thr His Thr His Leu Ala Gln
1185                1190                1195                1200
Gly Tyr Arg Arg Gly Ala Lys Lys Leu Glu Ser Ser Glu Glu Asn Leu
                1205                1210                1215    
Ser Ser Glu Asp Glu Glu Leu Pro Cys Phe Gln His Leu Leu Phe Gly
            1220                1225                1230        
Lys Val Asn Asn Ile Pro Ser Gln Ser Thr Arg His Ser Thr Val Ala
        1235                1240                1245            
Thr Glu Cys Leu Ser Lys Asn Thr Glu Glu Asn Leu Leu Ser Leu Lys
    1250                1255                1260                
Asn Ser Leu Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys Ala Ser
1265                1270                1275                1280
Gln Glu His His Leu Ser Glu Glu Thr Lys Cys Ser Ala Ser Leu Phe
                1285                1290                1295    
Ser Ser Gln Cys Ser Glu Leu Glu Asp Leu Thr Ala Asn Thr Asn Thr
            1300                1305                1310        
Gln Asp Pro Phe Leu Ile Gly Ser Ser Lys Gln Met Arg His Gln Ser
        1315                1320                1325            
Glu Ser Gln Gly Val Gly Leu Ser Asp Lys Glu Leu Val Ser Asp Asp
    1330                1335                1340                
Glu Glu Arg Gly Thr Gly Leu Glu Glu Asn Asn Gln Glu Glu Gln Ser
1345                1350                1355                1360
Met Asp Ser Asn Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr
                1365                1370                1375    
Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu
            1380                1385                1390        
Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu Gln
        1395                1400                1405            
Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln
    1410                1415                1420                
Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu
1425                1430                1435                1440
Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Ala Val Leu Thr
                1445                1450                1455    
Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu
            1460                1465                1470        
Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn
        1475                1480                1485            
Lys Glu Pro Gly Val Glu Arg Cys
    1490                1495    


<210> 8186
<211> 662
<212> PRT
<213> Homo sapiens

<400> 8186
Met Ala Leu Ile Thr Leu Arg Lys Asn Leu Tyr Arg Leu Ser Asp Phe
 1               5                  10                  15      
Gln Met His Arg Ala Leu Ala Ala Leu Lys Asn Lys Pro Leu Asn His
            20                  25                  30          
Val His Lys Val Val Lys Glu Arg Leu Cys Pro Trp Leu Cys Ser Arg
        35                  40                  45              
Gln Pro Glu Pro Phe Gly Val Lys Phe His His Ala His Cys Lys Lys
    50                  55                  60                  
Phe His Ser Lys Asn Gly Asn Asp Leu His Pro Leu Gly Gly Pro Val
65                  70                  75                  80  
Phe Ser Gln Val Ser Asp Cys Asp Arg Leu Glu Gln Asn Val Lys Asn
                85                  90                  95      
Glu Glu Ser Gln Met Phe Tyr Arg Arg Leu Ser Asn Leu Thr Ser Ser
            100                 105                 110         
Glu Glu Val Leu Ser Phe Ile Ser Thr Met Glu Thr Leu Pro Asp Thr
        115                 120                 125             
Met Ala Ala Gly Ala Leu Gln Arg Ile Cys Glu Val Glu Lys Lys Asp
    130                 135                 140                 
Gly Asp Gln Gly Leu Pro Lys Glu Ile Leu Glu Asn Ser Ile Phe Gln
145                 150                 155                 160 
Ala Leu Cys Phe Gln Phe Glu Lys Glu Pro Ser Gln Leu Ser Asn Thr
                165                 170                 175     
Ser Leu Val Thr Ala Leu Gln Ala Leu Ile Leu Leu His Val Asp Pro
            180                 185                 190         
Gln Ser Ser Leu Leu Leu Asn Leu Val Ala Glu Cys Gln Asn Arg Leu
        195                 200                 205             
Arg Lys Gly Gly Met Glu Val Arg Asn Leu Cys Ile Leu Gly Glu Ser
    210                 215                 220                 
Leu Ile Thr Leu His Ser Ser Gly Cys Val Thr Leu Glu Leu Ile Ile
225                 230                 235                 240 
Asn Gln Leu Gln Gly Glu Lys Leu Glu Thr Phe Thr Pro Glu Asp Ile
                245                 250                 255     
Val Ala Leu Tyr Arg Ile Leu Gln Ala Cys Thr Glu Lys Val Asp Glu
            260                 265                 270         
His Gln Thr Phe Leu Asn Lys Ile Asn Asn Phe Ser Leu Ser Ile Val
        275                 280                 285             
Ser Asn Leu Ser Pro Lys Leu Ile Ser Gln Met Leu Thr Ala Leu Val
    290                 295                 300                 
Val Leu Asp Gln Ser Gln Ala Phe Pro Leu Ile Ile Lys Leu Gly Lys
305                 310                 315                 320 
Tyr Val Val Arg His Val Pro His Phe Thr Asn Glu Glu Leu Arg Arg
                325                 330                 335     
Val Leu Glu Ala Phe Ile Tyr Phe Gly His His Asp Thr Phe Phe Thr
            340                 345                 350         
Lys Ala Leu Glu His Arg Val Ala Ala Val Cys Leu Thr Leu Asp Pro
        355                 360                 365             
Glu Val Val Cys Arg Val Met Glu Tyr Cys Ser Arg Glu Leu Ile Leu
    370                 375                 380                 
Ser Lys Pro Ile Leu Asn Ala Val Ala Glu Thr Phe Val Cys Gln Thr
385                 390                 395                 400 
Glu Lys Phe Ser Pro Arg Gln Ile Ser Ala Leu Met Glu Pro Phe Gly
                405                 410                 415     
Lys Leu Asn Tyr Leu Pro Pro Asn Ala Ser Ala Leu Phe Arg Lys Leu
            420                 425                 430         
Glu Asn Val Leu Phe Thr His Phe Asn Tyr Phe Pro Pro Lys Ser Leu
        435                 440                 445             
Leu Lys Leu Leu His Ser Cys Ser Leu Asn Glu Cys His Pro Val Asn
    450                 455                 460                 
Phe Leu Ala Lys Ile Phe Lys Pro Leu Phe Leu Gln Arg Leu Gln Gly
465                 470                 475                 480 
Lys Glu Ser His Leu Asp Thr Leu Ser Arg Ala Gln Leu Thr Gln Leu
                485                 490                 495     
Phe Leu Ala Ser Val Leu Glu Cys Pro Phe Tyr Lys Gly Pro Lys Leu
            500                 505                 510         
Leu Pro Lys Tyr Gln Val Lys Ser Phe Leu Thr Pro Cys Cys Ser Leu
        515                 520                 525             
Glu Thr Pro Val Asp Ser Gln Leu Tyr Arg Tyr Val Lys Ile Gly Leu
    530                 535                 540                 
Thr Asn Leu Leu Gly Ala Arg Leu Tyr Phe Ala Pro Lys Val Leu Thr
545                 550                 555                 560 
Pro Tyr Cys Tyr Thr Ile Asp Val Glu Ile Lys Leu Asp Glu Glu Gly
                565                 570                 575     
Phe Val Leu Pro Ser Thr Ala Asn Glu Asp Ile His Lys Arg Ile Ala
            580                 585                 590         
Leu Cys Ile Asp Gly Pro Lys Arg Phe Cys Ser Asn Ser Lys His Leu
        595                 600                 605             
Leu Gly Lys Glu Ala Ile Lys Gln Arg His Leu Gln Leu Leu Gly Tyr
    610                 615                 620                 
Gln Val Val Gln Ile Pro Tyr His Glu Ile Gly Met Leu Lys Ser Arg
625                 630                 635                 640 
Arg Glu Leu Val Glu Tyr Leu Gln Arg Lys Leu Phe Ser Gln Asn Thr
                645                 650                 655     
Val His Trp Leu Gln Glu
            660         


<210> 8187
<211> 1030
<212> PRT
<213> Homo sapiens

<400> 8187
Met Ala Leu Ser Pro Gly Ala Asn Leu Val Phe His Glu Asp Pro Lys
 1               5                  10                  15      
Met Thr Pro Ser Pro Pro Ser Cys Gly Ala Pro Gly Leu Gly Ser Gly
            20                  25                  30          
Thr Ile Pro Gln Pro His Pro Asp Met Ala Gln Val Pro Met Leu Asn
        35                  40                  45              
Leu Leu Pro Ser Pro Gly Leu Ala Leu Val Pro Asp Leu Asn Asp Ser
    50                  55                  60                  
Leu Ser Pro Val Ser Gly Glu Ala Ser Gly Leu Val Ser Glu Asn Thr
65                  70                  75                  80  
Pro Arg Pro Asp Asp Ser Arg Ala Ile Ala Pro Ala Ser Leu Gln Ile
                85                  90                  95      
Thr Ser Ser Cys Ser Gly Glu Ala Leu Asp Leu Asp Ser Lys Asp Val
            100                 105                 110         
Ser Arg Pro Asp Ser Gln Gly Arg Leu Cys Pro Ala Ser Asn Pro Ile
        115                 120                 125             
Leu Ser Pro Ser Ser Thr Glu Ala Pro Arg Leu Ser Ser Gly Asn His
    130                 135                 140                 
Pro Gln Ser Asn Ser Glu Asp Ala Phe Lys Cys Leu Ser Ser Lys Ile
145                 150                 155                 160 
Phe Lys Leu Gly Gln Arg Asn Ser Asn Pro Ser Arg His Glu Leu Asn
                165                 170                 175     
Pro Phe Ile Arg His His Ser Arg Glu Gly Leu Val Leu Gly His Cys
            180                 185                 190         
Ile Ser Arg Pro Ser Ser Lys Ala Leu Leu Ile Pro Thr Ser Asn Ser
        195                 200                 205             
Ser Leu Asp Leu Asp Ser Asn Pro Leu Leu Asn Met Gly Ser Arg Asn
    210                 215                 220                 
Thr Ser Lys Leu Asn Leu Asn Val Ala Pro Asp Ser His Gly Thr Leu
225                 230                 235                 240 
Ile Pro Asp Thr Asn Glu Thr Ile Thr Leu Ala Ser His Asn Ile Ser
                245                 250                 255     
Glu Ser Val Ser Lys Gly Ala Phe Ser Thr Thr Trp Ser Thr Ser Ser
            260                 265                 270         
Lys Glu Thr Met Asn Val Ala Ser Ser Gly His Ser Arg Ser Asp Leu
        275                 280                 285             
Ser Val Thr Ile Thr Gln Ala Ser Tyr Val Thr Leu Ile Pro Gly Ser
    290                 295                 300                 
Ser Tyr Gly Ile Ser Leu His Ser Ser Thr His Gly Pro Asn Ser Thr
305                 310                 315                 320 
Ile Ser Pro Pro Ser Cys Met Thr Leu Ile Leu Gly Ser Asn Glu Thr
                325                 330                 335     
Leu Ser Leu Asp Ser Ser Leu Leu Phe Ser Asp Thr Ser Thr Leu Thr
            340                 345                 350         
Leu Ser Ser Gln Gln Asp Asp Ala Lys Asp Asn Ser Ile His Thr Val
        355                 360                 365             
Pro Leu Glu Glu Asn Leu Glu Ser Trp Ser Glu Met Ala Ser Ile Lys
    370                 375                 380                 
Val Gly Gln Phe Pro Leu Gly Phe Pro Ile Ser Asn Pro Ala Gly Lys
385                 390                 395                 400 
Asp Ala Val Thr Leu Gln Gly Ile Pro Glu Gly Ala Phe Asp Glu Val
                405                 410                 415     
Thr Ser Cys Leu Val Lys Val Pro Glu Lys Thr Glu Gly Gly Asn Asn
            420                 425                 430         
Met Ala Leu Val Glu Asn Val Thr Thr Leu Gln Lys Ser Gln Asp Leu
        435                 440                 445             
Leu Glu Ala Glu Gly Glu Lys Lys Thr Met Ile Lys Lys Ile Met Arg
    450                 455                 460                 
Gln Ile Gln Glu Glu Pro Leu Asp Ser Leu Ser Ser Ser Val Arg Lys
465                 470                 475                 480 
Gln Ala Met Glu Ile Leu Thr Gln Leu Ser His Thr Gln Pro Thr Leu
                485                 490                 495     
Gly Met Arg Glu Arg Ser Glu Leu Val Asn Val Cys Val His Ser Val
            500                 505                 510         
Phe Ser Leu Pro Ser Val Gln Ala Met Gln Glu Lys Asp Glu Ala Lys
        515                 520                 525             
Ala Glu Thr Ile Gln Ala Leu Tyr His Gln Thr Leu Glu Ala Leu Gln
    530                 535                 540                 
Thr Leu Leu Lys Ala Leu Phe Ile Glu Asp Pro Thr Pro Ala Gly Leu
545                 550                 555                 560 
Lys Ser Ile Leu Glu Ala Leu Gly Pro Trp Met Asn Ser Gly Lys Ala
                565                 570                 575     
His Glu Arg Ala Arg Ala Val Asn Thr Asn Val Ser Val Leu Asn His
            580                 585                 590         
Met Leu Leu Thr Leu Pro Phe Phe Met Pro Leu Gly Phe Pro Ala Leu
        595                 600                 605             
Gly Leu Leu Leu Gly Arg Leu Ile Leu His Ile Gly Asp Pro Asp Glu
    610                 615                 620                 
Glu Ile Gly Cys Glu Ala Leu Asp Gly Ile Ile Ile Leu Tyr Thr Ile
625                 630                 635                 640 
Leu Glu Leu Gln Lys Arg Ala Arg Asp Lys Glu Glu Thr Asn Lys Lys
                645                 650                 655     
Glu Leu Tyr Glu Ser Asn Lys His Phe Leu Gly Pro Tyr Asn Pro Val
            660                 665                 670         
Ser Pro Cys Gln Asn Ile Leu Arg Val Ile Glu Glu Phe Gly Asp Phe
        675                 680                 685             
Leu Gly Pro Gln Gln Ile Lys Asp Leu Leu Leu Ala Ala Leu Glu Gly
    690                 695                 700                 
Leu Lys Gly Ser Ser Glu Ala Pro Gly Lys Asp Ser Arg Glu Met Met
705                 710                 715                 720 
Gln Leu Ala Ser Glu Val Met Leu Ser Ser Val Leu Glu Trp Tyr Arg
                725                 730                 735     
His Arg Ala Leu Glu Val Ile Pro Glu Ile Met Gln Gly Ile Tyr Met
            740                 745                 750         
Gln Leu Ser His Ile Gln Glu Pro Arg Ala Arg Gln Val Ala Leu Leu
        755                 760                 765             
Pro Val Ser Leu Leu Ala Ser Ser Phe Met Thr Glu Val Val Val Ala
    770                 775                 780                 
Leu Leu Met Cys Pro Leu Pro Leu Asn Ser Asn Gly Ala Glu Met Trp
785                 790                 795                 800 
Arg Gln Leu Ile Leu Cys Lys Pro Ser Cys Asp Val Arg Asp Leu Leu
                805                 810                 815     
Asp Leu Leu Leu Gly Ser Leu Lys Glu Lys Pro Val Thr Lys Glu Gly
            820                 825                 830         
Arg Ala Ser Ile Val Pro Leu Ala Ala Ala Ser Gly Leu Cys Glu Leu
        835                 840                 845             
Leu Ser Val Asn Ser Cys Met Gly Arg Val Arg Arg Ile Tyr Pro Gln
    850                 855                 860                 
Leu Leu Leu Ala Leu Leu Ile Gln Val His Tyr His Ile Gly Leu Asn
865                 870                 875                 880 
Leu Pro Gly Cys Val Ala Pro Pro Lys Asp Thr Lys Lys Gly Ala Gln
                885                 890                 895     
Pro Ser Pro Phe Val Pro Val Arg Trp Val Val Lys Val Val Lys Thr
            900                 905                 910         
Leu Leu Leu Arg Met Gly Cys Ser Tyr Glu Thr Thr Phe Leu Glu Asp
        915                 920                 925             
Gln Gly Gly Trp Glu Leu Met Glu Gln Val Glu Ser His His Arg Gly
    930                 935                 940                 
Val Ala Leu Leu Ala Arg Ala Met Val Gln Tyr Ser Cys Gln Glu Leu
945                 950                 955                 960 
Cys Arg Ile Leu Tyr Leu Leu Ile Pro Leu Leu Glu Arg Gly Asp Glu
                965                 970                 975     
Lys His Arg Ile Thr Ala Thr Ala Phe Phe Val Glu Gln Pro Cys Glu
            980                 985                 990         
Glu Gly Ile Val Ile Leu Met Leu Arg Pro Gln Asp Leu Met Gly Lys
        995                 1000                1005            
Ala Thr Thr Ser Ser His Arg Gly Ser Glu Leu Glu Ser Asp Thr Leu
    1010                1015                1020                
Ser Phe Ala Thr Trp Cys
1025                1030


<210> 8188
<211> 421
<212> PRT
<213> Homo sapiens

<400> 8188
Met Ala Leu Ser Pro Gly Ala Asn Leu Val Phe His Glu Asp Pro Lys
 1               5                  10                  15      
Met Thr Pro Ser Pro Pro Ser Cys Gly Ala Pro Gly Leu Gly Ser Gly
            20                  25                  30          
Thr Ile Pro Gln Pro His Pro Asp Met Ala Gln Val Pro Met Leu Asn
        35                  40                  45              
Leu Leu Pro Ser Pro Gly Leu Ala Leu Val Pro Asp Leu Asn Asp Ser
    50                  55                  60                  
Leu Ser Pro Val Ser Gly Glu Ala Ser Gly Leu Val Ser Glu Asn Thr
65                  70                  75                  80  
Pro Arg Pro Asp Asp Ser Arg Ala Ile Ala Pro Ala Ser Leu Gln Ile
                85                  90                  95      
Thr Ser Ser Cys Ser Gly Glu Ala Leu Asp Leu Asp Ser Lys Asp Val
            100                 105                 110         
Ser Arg Pro Asp Ser Gln Gly Arg Leu Cys Pro Ala Ser Asn Pro Ile
        115                 120                 125             
Leu Ser Pro Ser Ser Thr Glu Ala Pro Arg Leu Ser Ser Gly Asn His
    130                 135                 140                 
Pro Gln Ser Asn Ser Glu Asp Ala Phe Lys Cys Leu Ser Ser Lys Ile
145                 150                 155                 160 
Phe Lys Leu Gly Gln Arg Asn Ser Asn Pro Ser Arg His Glu Leu Asn
                165                 170                 175     
Pro Phe Ile Arg His Arg Ser Arg Glu Gly Leu Val Leu Gly His Cys
            180                 185                 190         
Ile Ser Arg Pro Ser Ser Lys Ala Leu Leu Ile Pro Thr Ser Asn Ser
        195                 200                 205             
Ser Leu Asp Leu Asp Ser Asn Pro Leu Leu Asn Met Gly Ser Arg Asn
    210                 215                 220                 
Thr Ser Lys Leu Asn Leu Asn Val Ala Pro Asp Ser His Gly Thr Leu
225                 230                 235                 240 
Ile Pro Asp Thr Asn Glu Thr Ile Thr Leu Ala Ser His Asn Ile Ser
                245                 250                 255     
Glu Ser Val Ser Lys Gly Ala Phe Ser Thr Thr Trp Ser Thr Ser Ser
            260                 265                 270         
Lys Glu Thr Met Asn Val Ala Ser Ser Gly His Ser Arg Ser Asp Leu
        275                 280                 285             
Ser Val Thr Ile Thr Gln Ala Ser Tyr Val Thr Leu Ile Pro Gly Ser
    290                 295                 300                 
Ser Tyr Gly Ile Ser Leu His Ser Ser Thr His Gly Pro Asn Ser Thr
305                 310                 315                 320 
Ile Ser Pro Pro Ser Cys Met Thr Leu Ile Leu Gly Ser Asn Glu Thr
                325                 330                 335     
Leu Ser Leu Asp Ser Ser Leu Leu Phe Ser Asp Thr Ser Thr Leu Thr
            340                 345                 350         
Leu Ser Ser Gln Gln Asp Asp Ala Lys Asp Asn Ser Ile His Thr Val
        355                 360                 365             
Pro Leu Glu Glu Asn Leu Glu Ser Trp Ser Glu Met Ala Ser Ile Lys
    370                 375                 380                 
Val Gly Gln Phe Pro Leu Gly Phe Pro Ile Ser Asn Pro Ala Gly Lys
385                 390                 395                 400 
Asp Ala Val Thr Leu Gln Gly Ile Pro Glu Gly Val Ser Gly Ser Ser
                405                 410                 415     
Trp Thr Phe Pro Ala
            420     


<210> 8189
<211> 2153
<212> PRT
<213> Homo sapiens

<400> 8189
Met Glu Pro Ala Gly Glu Glu Glu Arg Pro Pro Pro Ala Ala Glu Gly
 1               5                  10                  15      
Glu Asp Asp Glu Glu Glu Val Ala Ala Ala Ala Gln Thr Ser Gly Pro
            20                  25                  30          
Ala His Gly Arg Ser Ala Ser Ser Leu Glu Asp Ala Asp Asp Gln Glu
        35                  40                  45              
Glu Glu Met Glu Ala Met Val Ile Gly Gly Gly Cys Cys Lys Glu Gln
    50                  55                  60                  
Glu Leu Thr Tyr Glu Leu Gln Gln Gly Tyr Arg Ile Leu Gly Glu Phe
65                  70                  75                  80  
Leu Gln Glu Lys His Arg Gly Leu Thr Ala Pro Phe Leu Gln Pro Leu
                85                  90                  95      
Gly Gly Val Ala Thr Ala Glu Glu Glu Val Ala Glu Gly Pro Arg Ser
            100                 105                 110         
Gly Gly Arg Gly Gly Arg Ala Phe Pro Gln Gln Pro Gly Gln Gly Met
        115                 120                 125             
Cys Leu Leu Gln Met Glu Glu Lys Phe Ala Ser Gly Gln Tyr Gly Gly
    130                 135                 140                 
Ile Thr Glu Phe Val Ala Asp Phe Arg Leu Met Leu Glu Thr Cys Tyr
145                 150                 155                 160 
Arg Leu His Gly Val Asp His Trp Ile Ser Lys Gln Gly Gln Lys Leu
                165                 170                 175     
Glu Met Met Leu Glu Gln Lys Leu Ala Leu Leu Ser Arg His Leu Arg
            180                 185                 190         
Glu Lys Thr Thr Ile Ala Val Thr Ser Arg Gly Tyr Tyr Gly Leu Glu
        195                 200                 205             
Asp Glu Lys Gly Thr Ala Cys Thr Ser Thr Arg Arg Arg Ser Thr Pro
    210                 215                 220                 
Arg Ser Leu Ala Gly Leu Thr Ser Gly Val Phe Glu Ser Ile Met Val
225                 230                 235                 240 
Gln Val Leu Arg Gln Glu Glu Gln Leu Arg Ala Lys Glu Glu Lys Arg
                245                 250                 255     
Ala Ser Gln Asn Tyr Ser Tyr Tyr Arg Lys Gly Gly Leu Met Glu Arg
            260                 265                 270         
Gly Ala Ser Gln Leu Val Leu Thr Leu Ala Tyr Gln Ala Asn Cys Val
        275                 280                 285             
Ser Val Ser Tyr Thr Asp Leu Leu Gly Lys Pro Gly Gly Ser Tyr Phe
    290                 295                 300                 
Thr Phe Leu Tyr Val Leu Asn Ile Arg Ser Arg Leu Arg Glu Gln Glu
305                 310                 315                 320 
Arg Lys Glu Ala Glu Glu Ala Ser Gln Lys Glu Ile Glu Glu Trp Glu
                325                 330                 335     
Arg Lys Leu Leu Ala Gln Ala Ala Pro Thr Cys Met Glu Thr Met Trp
            340                 345                 350         
Glu Ile Pro Ala Ile Gly His Phe Leu Cys Leu Ala Gln Gln Ile Leu
        355                 360                 365             
Asn Leu Pro Glu Ile Val Phe Tyr Glu Leu Glu Arg Cys Leu Leu Met
    370                 375                 380                 
Pro Gln Cys Asn Ala Phe Leu Ser Lys Ile Met Thr Ser Leu Leu Ser
385                 390                 395                 400 
Pro Pro His Arg Arg Pro Thr Leu His Arg Arg Pro Thr Leu Pro Tyr
                405                 410                 415     
Arg Thr Trp Glu Ala Ala Leu Arg Gln Lys Val Gln Gln Trp Tyr Thr
            420                 425                 430         
Ala Val Gly Gln Thr Glu Asn Pro Asp Asn Cys Ala Glu Lys Leu Gly
        435                 440                 445             
Leu Cys Pro Gln Phe Phe Lys Val Leu Gly Glu Val Asn Pro Leu Glu
    450                 455                 460                 
Glu Lys Pro Phe His Glu Leu Pro Phe Tyr Gln Lys Val Trp Leu Leu
465                 470                 475                 480 
Lys Gly Leu Cys Asp Phe Val Tyr Glu Thr Gln Lys Glu Val Gln Asp
                485                 490                 495     
Ala Val Leu Gly Gln Pro Ile His Glu Cys Arg Glu Val Ile Leu Gly
            500                 505                 510         
Tyr Asp Tyr Leu Glu Asn Ala Tyr Val His Phe Pro Gln Phe Cys Gly
        515                 520                 525             
Ala Asp Val Arg Ile Tyr Lys Gln Arg Pro Phe Gln Ala Pro Glu Phe
    530                 535                 540                 
Pro Ile Pro Pro Ile Lys Ile Gln Arg Val Pro Arg Ile Lys Leu Glu
545                 550                 555                 560 
Lys Leu Lys Cys Asp Tyr Val Ser Thr Ser Asn Gly Glu His Arg Cys
                565                 570                 575     
Ser Arg Asp Ser Leu Pro Ser Ser Phe Lys Lys Glu Gln Glu Asn Asn
            580                 585                 590         
Phe Asp Pro Ala Cys Cys Pro Ala Lys Met Ile Leu Asp Asn His Asp
        595                 600                 605             
Ile Ser Val Glu Met Gly Val Lys Ser Asn Tyr Glu Ile Arg Ile Arg
    610                 615                 620                 
Arg Pro Cys Glu Ile Lys Lys Thr Asp Cys Cys Lys Glu Asn Leu Glu
625                 630                 635                 640 
Lys Pro Arg Ser Pro Gly Glu Val Thr Gly Phe Gly Glu Pro Leu Ser
                645                 650                 655     
Pro Gly Glu Ile Arg Phe Ile Glu Asn Gln Glu Lys Tyr Gly Glu Ala
            660                 665                 670         
Ser Arg Ile Lys Ile Glu Pro Ser Pro Leu Lys Glu Asn Thr Leu Lys
        675                 680                 685             
Ser Cys Gln Ile His Val Asn Gly Ser His Ser Asp His Pro Glu Ile
    690                 695                 700                 
Asn Cys His Lys Val Val Arg Asp Ile Leu Leu Glu Gln Ser Leu Gln
705                 710                 715                 720 
Ser His Lys Lys Leu Lys Leu Thr Lys Met Arg Ala Lys Lys Lys Lys
                725                 730                 735     
Lys Lys Lys Lys Lys Leu Lys Asp Val Leu Asn Glu Asn Leu Gln Arg
            740                 745                 750         
Lys Arg Glu Gly Leu His Ser Leu Ala Phe Lys Ser Tyr Lys Pro Glu
        755                 760                 765             
Ile Gln Asn Lys Leu Leu Ile Ile Lys Lys Lys Ala Lys His Lys Lys
    770                 775                 780                 
His Lys Ser Gly Lys Lys Ser Val Ser Lys Lys Ala Ile Thr Lys Lys
785                 790                 795                 800 
Arg Lys Thr Val Ile Lys Ser Pro Thr Val Pro Glu Phe Gln Leu Ile
                805                 810                 815     
Cys Thr Asn Leu Asp Glu Leu Arg Glu Leu Ile Thr Lys Ile Glu Asn
            820                 825                 830         
Glu Leu Lys Asp Leu Glu Asn Ser Arg Lys Lys Ser Gly Lys Trp Tyr
        835                 840                 845             
His Arg Arg Gln Ala Val Lys Glu Leu His Ser Thr Leu Ile Arg Leu
    850                 855                 860                 
Leu Asn Glu Leu Leu Pro Trp Glu Pro Lys Leu Met Lys Ala Phe Gln
865                 870                 875                 880 
Arg Asn Arg Ser Arg Leu Lys Lys Asp Tyr Asp Asp Phe Arg Arg Gln
                885                 890                 895     
Pro Asp His Asp Thr Phe Asn Arg Glu Leu Trp Thr Thr Asp Glu Gly
            900                 905                 910         
Glu Gly Asp Leu Gly Lys Asp Ser Pro Lys Gly Glu Ile Ser Lys Ser
        915                 920                 925             
Ile Asp Ser Thr Glu Pro Leu Asp Ile Leu Glu Lys Asp His Phe Asp
    930                 935                 940                 
Ser Asp Asp Met Lys Leu Ser Glu Ile Asp Phe Pro Met Ala Arg Ser
945                 950                 955                 960 
Lys Leu Leu Lys Lys Glu Leu Pro Ser Lys Asp Leu Pro Lys Thr Leu
                965                 970                 975     
Leu Lys Thr Leu Lys Arg Gln Ser Lys Gln Thr Asp Tyr Val Asp Asp
            980                 985                 990         
Ser Thr Lys Glu Leu Ser Pro Arg Lys Lys Ala Lys Leu Ser Thr Asn
        995                 1000                1005            
Glu Thr Thr Val Glu Asn Leu Glu Ser Asp Val Gln Ile Asp Cys Phe
    1010                1015                1020                
Ser Glu Ser Lys His Thr Glu Pro Ser Phe Pro Glu Ser Phe Ala Ser
1025                1030                1035                1040
Leu Asp Ser Val Pro Val Ser Thr Leu Gln Lys Gly Thr Lys Pro Ile
                1045                1050                1055    
Gln Ala Leu Leu Ala Lys Asn Ile Gly Asn Lys Val Thr Leu Thr Asn
            1060                1065                1070        
Gln Leu Pro Pro Ser Thr Gly Arg Asn Ala Leu Ala Val Glu Lys Pro
        1075                1080                1085            
Val Leu Ser Pro Pro Glu Ala Ser Pro Ile Lys Pro Ala Leu Thr Cys
    1090                1095                1100                
His Thr Asn Thr Lys Gly Pro Leu Gln Met Val Tyr Lys Met Pro Cys
1105                1110                1115                1120
Gly Gln Trp Leu Pro Ile Asp Leu Gln Asn Ser Ser Val Lys Ile Gln
                1125                1130                1135    
Val Gln Pro Met Val Asp Pro Lys Thr Gly Glu Lys Ile Met Gln Gln
            1140                1145                1150        
Val Leu Ile Leu Pro Lys Asn Phe Val Ile Gln His Lys Glu Gly Lys
        1155                1160                1165            
Ala Val Ala Lys Glu Val Pro Pro Leu Gln Gln Lys Gly Thr Glu Gln
    1170                1175                1180                
His Cys Ser Ser Phe Pro Gln Thr Thr Asn Ile Asn Ser Ser Leu Ala
1185                1190                1195                1200
Ser Val Phe Val Asn Ser Pro Gly Thr Val Ser Thr Gln Leu Pro Asn
                1205                1210                1215    
Thr Ala Phe Asn Lys Thr Ile Thr Pro Leu Ser Asn Ile Ser Ser Ala
            1220                1225                1230        
Arg Pro Gln Pro Leu Ser Pro Val Thr Ser Val Ser Asn Leu Leu Thr
        1235                1240                1245            
Pro Ser Val Lys Thr Ser Gln Ser Glu Ala Gly Lys Ala Lys Asn Ala
    1250                1255                1260                
Val Ser Ala Ala Thr Phe Ser Leu Pro Ser Ala Ser Pro Thr Ile Ser
1265                1270                1275                1280
Ser Thr Gly Gln Pro Leu Ser Ser Thr Thr Thr Leu Asn Gly Ser Thr
                1285                1290                1295    
Asn Pro Gly Ser Ser Phe Asn Cys Phe Ala Gln Gln Thr Ala Asp Ser
            1300                1305                1310        
Ser Glu Ala Lys Gln Glu Leu Lys Thr Val Cys Ile Arg Asp Ser Gln
        1315                1320                1325            
Ser Ile Leu Val Arg Thr Arg Gly Gly Asn Thr Gly Val Val Lys Val
    1330                1335                1340                
Gln Thr Asn Pro Asp Gln Asn Ser Pro Asn Thr Val Ser Ser Ser Ser
1345                1350                1355                1360
Val Phe Thr Phe Ala Pro Gln Leu Gln Ala Phe Leu Val Pro Lys Ser
                1365                1370                1375    
Thr Thr Ser Ser Ser Ala Phe Ser Pro Val Ala Gly Thr Thr Thr Thr
            1380                1385                1390        
Ser Ser Leu Ser Pro Phe Ser Gln Thr Pro Thr Ser Val Ser Ile Pro
        1395                1400                1405            
Ala Ser Phe Ala Pro Ser Met Gly Lys Asn Leu Lys Leu Thr Leu Gly
    1410                1415                1420                
His Thr Thr Gly Ser Gly Asp Leu Gly His Val Ile Asp Lys Thr Ser
1425                1430                1435                1440
His Met Pro Ser Ser Pro Leu Lys Ser Ser Ile Cys Ser Ser Thr Leu
                1445                1450                1455    
Leu Pro Ser Thr Thr Ser Ser Ser Val Ser Val Ile Ser Ile Ser Ala
            1460                1465                1470        
Ala Asn Phe Gly Gln Asn Asn Ala Asn Ile Ile His Thr Pro Thr Lys
        1475                1480                1485            
Gln Gln Gln Val Asp Tyr Ile Thr Lys Ser Tyr Pro Val Thr Arg Ser
    1490                1495                1500                
Glu Ala Thr Ala Ala Thr Asn Gly Asp Val Ile Ser Gly Thr Pro Val
1505                1510                1515                1520
Gln Lys Leu Met Leu Val Ser Ala Pro Ser Ile Leu Ser Ser Gly Asn
                1525                1530                1535    
Gly Thr Ala Ile Asn Met Thr Pro Ala Leu Thr Ser Thr Gly Val Ser
            1540                1545                1550        
Ala Gln Lys Leu Val Phe Ile Asn Ala Pro Val Pro Ser Gly Thr Ser
        1555                1560                1565            
Thr Pro Thr Leu Val Ala Glu Ser Leu Lys Gln Thr Leu Pro Pro Pro
    1570                1575                1580                
Leu His Lys Ala Tyr Val Lys Thr Pro Glu Gln Pro Gln Ile Val Leu
1585                1590                1595                1600
Ile Pro Ser Thr Val Gly Thr Pro Ile Lys Ile Asn Ser Ser Pro Ala
                1605                1610                1615    
Val Ser Gln Ile Lys Asp Val Lys Ile Gly Leu Asn Ile Gly Gln Ala
            1620                1625                1630        
Ile Val Asn Thr Ser Gly Thr Val Pro Ala Ile Pro Ser Ile Asn Ile
        1635                1640                1645            
Leu Gln Asn Val Thr Pro Lys Gly Glu Asp Lys Ser Ser Lys Gly Tyr
    1650                1655                1660                
Ile Leu Pro Leu Ser Thr Ser Gly Asn Ser Val Pro Val Ser Ser Asn
1665                1670                1675                1680
Phe Val Ser Gln Asn Ile Thr Pro Val Asn Glu Ser Val Val Ser Ser
                1685                1690                1695    
Ala Arg Ala Val Asn Val Leu Ser Val Thr Gly Ala Asn Leu Ser Leu
            1700                1705                1710        
Gly Ser Phe Pro Val Thr Ser Ala Ser Ala Ser Ala Gly Ala Gln Pro
        1715                1720                1725            
Pro Val Leu Val Ser Gly Asn Asp Thr Ser Ser Arg Ile Met Pro Ile
    1730                1735                1740                
Leu Ser Asn Arg Leu Cys Ser Ser Ser Leu Gly Asn Thr Val Ala Ile
1745                1750                1755                1760
Ser Thr Val Lys Thr Gly His Leu Ala Ser Ser Val Leu Ile Ser Thr
                1765                1770                1775    
Thr Gln Pro Val Val Ser Pro Lys Cys Leu Thr Ser Ala Leu Gln Ile
            1780                1785                1790        
Pro Val Thr Val Ala Leu Pro Thr Pro Ala Thr Thr Ser Pro Lys Ile
        1795                1800                1805            
Ile Asn Thr Val Pro His Ser Ala Ala Val Pro Gly Ala Thr Arg Ser
    1810                1815                1820                
Val Ser Ile Ser Lys Arg Gln Ser Arg Thr Ser Leu Gln Phe His Ser
1825                1830                1835                1840
Pro Gly Ile Ser Thr Thr Val Pro Thr Asn Val Asn Thr Asn Lys Pro
                1845                1850                1855    
Gln Thr Glu Leu Ser Ser Leu Ser Thr Ser Pro Gly Lys Ile Thr Asn
            1860                1865                1870        
Thr Ser Asn Phe Ala Ser Leu Pro Asn Gln Gln Ala Leu Val Lys Thr
        1875                1880                1885            
Pro Ser Tyr Ser Ser Ala Pro Gly Gly Thr Thr Ile His Thr Ala Ser
    1890                1895                1900                
Ala Pro Ser Asn Val Thr Ser Leu Val Gly Ser Gln Phe Ser Glu Pro
1905                1910                1915                1920
Cys Ile Gln Gln Lys Ile Val Ile Asn Thr Ser Thr Pro Leu Ala Pro
                1925                1930                1935    
Gly Thr Gln Ile Met Ile Asn Gly Thr Arg Phe Ile Val Pro Pro Gln
            1940                1945                1950        
Gly Leu Gly Ala Gly Ser His Val Leu Leu Ile Ser Thr Asn Pro Lys
        1955                1960                1965            
Tyr Gly Ala Pro Leu Val Leu Asn Ser Gly Gln Gly Ile Gln Ser Thr
    1970                1975                1980                
Pro Ile Asp Asn Ser Ala Gln Lys Ile Thr Leu Ala Ser Asn Asn Ser
1985                1990                1995                2000
Leu Ser Gly Gln Pro Leu Gln His Pro Leu Arg Ser Pro Thr Lys Phe
                2005                2010                2015    
Ile Asn Ser Phe Gly Asn Ala Ser Ser Ile Pro Thr Val His Thr Ser
            2020                2025                2030        
Pro Gln Leu Ile Asn Thr Thr Ala Lys Val Pro Val Pro Pro Pro Val
        2035                2040                2045            
Pro Thr Val Ser Leu Thr Ser Val Ile Lys Ser Pro Ala Thr Leu Leu
    2050                2055                2060                
Ala Lys Thr Ser Leu Val Ser Ala Ile Cys Pro Ser Asn Pro Pro Leu
2065                2070                2075                2080
Pro Ser Ser Thr Ser Val Phe His Leu Asp Pro Pro Val Lys Lys Leu
                2085                2090                2095    
Leu Val Ser Pro Glu Gly Ala Ile Leu Asn Thr Ile Asn Thr Pro Ala
            2100                2105                2110        
Ser Lys Val Ser Ser Leu Ser Pro Ser Leu Ser Gln Ile Val Val Ser
        2115                2120                2125            
Ala Ser Arg Ser Pro Ala Ser Val Phe Pro Ala Phe Gln Ser Ser Gly
    2130                2135                2140                
Leu Glu Lys Pro Asp Arg Ala Ala Ser
2145                2150            


<210> 8190
<211> 250
<212> PRT
<213> Homo sapiens

<400> 8190
Met Asp Met Leu Gln Asp Leu Glu Ser Leu Gln Phe Glu Tyr Gly Val
 1               5                  10                  15      
Pro Glu Glu Asp Arg Ile Trp Leu Tyr Leu Gln Gly Arg Ser Arg Gly
            20                  25                  30          
Leu Met Ile Glu Ala Cys Ala His Ala Thr Phe Phe Cys Lys Leu Leu
        35                  40                  45              
Tyr Asn Leu Arg Ala Ser Leu Asn Lys Asn Gln Ser Ser Arg His Leu
    50                  55                  60                  
Ser Ile Gly Ser Leu Asn Ser Ala Thr Pro Glu Glu Phe Lys Val Gly
65                  70                  75                  80  
Ile Ile Gly Gly Gly His Leu Gly Lys Gln Leu Ala Gly Thr Leu Leu
                85                  90                  95      
Gln Leu Gly Pro Ile Pro Ala Glu Ser Leu Arg Ile Ser Thr Arg Arg
            100                 105                 110         
Pro Glu Thr Leu Gly Glu Leu Gln Lys Leu Gly Ile Lys Cys Phe Tyr
        115                 120                 125             
His Asn Ala Asp Leu Val Ser Trp Ala Asp Val Ile Phe Leu Cys Cys
    130                 135                 140                 
Leu Pro Ser Gln Leu Pro Asn Ile Cys Val Glu Ile Tyr Thr Ser Leu
145                 150                 155                 160 
Glu Lys Ala Ser Ile Val Tyr Ser Phe Val Ala Ala Ile Pro Leu Pro
                165                 170                 175     
Arg Leu Lys Leu Leu Leu Asn His Thr Asn Ile Leu Arg Pro Gln Tyr
            180                 185                 190         
Gln Tyr Asp Glu Asp Ser Val Ser Val Trp Gly Ala Asn Lys Gly Val
        195                 200                 205             
Ile Ala Ala Leu Gln Asp Pro Thr Ile Leu Gln Ala Thr Cys Pro Tyr
    210                 215                 220                 
Ser Pro Ala Gly His Gly Ser Thr Tyr Phe Trp His Ser Phe Glu Asn
225                 230                 235                 240 
Tyr Phe Pro Val Gly Pro Leu Leu Ser Tyr
                245                 250 


<210> 8191
<211> 584
<212> PRT
<213> Homo sapiens

<400> 8191
Met Asp Glu Gly Cys Gly Glu Thr Ile Tyr Val Ile Gly Gln Gly Ser
 1               5                  10                  15      
Asp Gly Thr Glu Tyr Gly Leu Ser Glu Ala Asp Met Glu Ala Ser Tyr
            20                  25                  30          
Ala Thr Val Lys Ser Met Ala Glu Gln Ile Glu Ala Asp Val Ile Leu
        35                  40                  45              
Leu Arg Glu Arg Gln Glu Ala Gly Gly Arg Val Arg Asp Tyr Leu Val
    50                  55                  60                  
Arg Lys Arg Val Gly Asp Asn Asp Phe Leu Glu Val Arg Val Ala Val
65                  70                  75                  80  
Val Gly Asn Val Asp Ala Gly Lys Ser Thr Leu Leu Gly Val Leu Thr
                85                  90                  95      
His Gly Glu Leu Asp Asn Gly Arg Gly Phe Ala Arg Gln Lys Leu Phe
            100                 105                 110         
Arg His Lys His Glu Ile Glu Ser Gly Arg Thr Ser Ser Val Gly Asn
        115                 120                 125             
Asp Ile Leu Gly Phe Asp Ser Glu Gly Asn Val Val Asn Lys Pro Asp
    130                 135                 140                 
Ser His Gly Gly Ser Leu Glu Trp Thr Lys Ile Cys Glu Lys Ser Thr
145                 150                 155                 160 
Lys Val Ile Thr Phe Ile Asp Leu Ala Gly His Glu Lys Tyr Leu Lys
                165                 170                 175     
Thr Thr Val Phe Gly Met Thr Gly His Leu Pro Asp Phe Cys Met Leu
            180                 185                 190         
Met Val Gly Ser Asn Ala Gly Ile Val Gly Met Thr Lys Glu His Leu
        195                 200                 205             
Gly Leu Ala Leu Ala Leu Asn Val Pro Val Phe Val Val Val Thr Lys
    210                 215                 220                 
Ile Asp Met Cys Pro Ala Asn Ile Leu Gln Glu Thr Leu Lys Leu Leu
225                 230                 235                 240 
Gln Arg Leu Leu Lys Ser Pro Gly Cys Arg Lys Ile Pro Val Leu Val
                245                 250                 255     
Gln Ser Lys Asp Asp Val Ile Val Thr Ala Ser Asn Phe Ser Ser Glu
            260                 265                 270         
Arg Met Cys Pro Ile Phe Gln Ile Ser Asn Val Thr Gly Glu Asn Leu
        275                 280                 285             
Asp Leu Leu Lys Met Phe Leu Asn Leu Leu Ser Pro Arg Thr Ser Tyr
    290                 295                 300                 
Arg Glu Glu Glu Pro Ala Glu Phe Gln Ile Asp Asp Thr Tyr Ser Val
305                 310                 315                 320 
Pro Gly Val Gly Thr Val Val Ser Gly Thr Thr Leu Arg Gly Leu Ile
                325                 330                 335     
Lys Leu Asn Asp Thr Leu Leu Leu Gly Pro Asp Pro Leu Gly Asn Phe
            340                 345                 350         
Leu Ser Ile Ala Val Lys Ser Ile His Arg Lys Arg Met Pro Val Lys
        355                 360                 365             
Glu Val Arg Gly Gly Gln Thr Ala Ser Phe Ala Leu Lys Lys Ile Lys
    370                 375                 380                 
Arg Ser Ser Ile Arg Lys Gly Met Val Met Val Ser Pro Arg Leu Asn
385                 390                 395                 400 
Pro Gln Ala Ser Trp Glu Phe Glu Ala Glu Ile Leu Val Leu His His
                405                 410                 415     
Pro Thr Thr Ile Ser Pro Arg Tyr Gln Ala Met Val His Cys Gly Ser
            420                 425                 430         
Ile Arg Gln Thr Ala Thr Ile Leu Ser Met Asp Lys Asp Cys Leu Arg
        435                 440                 445             
Thr Gly Asp Lys Ala Thr Val His Phe Arg Phe Ile Lys Thr Pro Glu
    450                 455                 460                 
Tyr Leu His Ile Asp Gln Arg Leu Val Phe Arg Glu Gly Arg Thr Lys
465                 470                 475                 480 
Ala Val Gly Thr Ile Thr Lys Leu Leu Gln Thr Thr Asn Asn Ser Pro
                485                 490                 495     
Met Asn Ser Lys Pro Gln Gln Ile Lys Met Gln Ser Thr Lys Lys Gly
            500                 505                 510         
Pro Leu Thr Lys Arg Asp Glu Gly Gly Pro Ser Gly Gly Pro Ala Val
        515                 520                 525             
Gly Ala Pro Pro Pro Gly Asp Glu Ala Ser Ser Val Gly Ala Gly Gln
    530                 535                 540                 
Pro Ala Ala Ser Ser Asn Leu Gln Pro Gln Pro Lys Pro Ser Ser Gly
545                 550                 555                 560 
Gly Arg Arg Arg Gly Gly Gln Arg His Lys Val Lys Ser Gln Gly Ala
                565                 570                 575     
Cys Val Thr Pro Ala Ser Gly Cys
            580                 


<210> 8192
<211> 481
<212> PRT
<213> Homo sapiens

<400> 8192
Gln Val Thr Phe Ser Asp Val Ala Ile Asp Phe Ser His Glu Glu Trp
 1               5                  10                  15      
Ala Cys Leu Asp Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val Met Val
            20                  25                  30          
Gln Asn Tyr Glu Asn Leu Val Ser Val Gly Leu Ser Val Thr Lys Pro
        35                  40                  45              
Tyr Val Ile Met Leu Leu Glu Asp Gly Lys Glu Pro Trp Met Met Glu
    50                  55                  60                  
Lys Lys Leu Ser Lys Ala Tyr Pro Phe Pro Leu Ser His Ser Val Pro
65                  70                  75                  80  
Ala Ser Val Asn Phe Gly Phe Ser Ala Leu Phe Glu His Cys Ser Glu
                85                  90                  95      
Val Thr Glu Ile Phe Glu Leu Ser Glu Leu Cys Val Phe Trp Val Leu
            100                 105                 110         
His Phe Leu Ser Asn Ser Pro Asn Ser Thr Val Glu Ala Phe Arg Ser
        115                 120                 125             
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
    130                 135                 140                 
Arg Gln Cys Phe Ala Phe Leu Ile Tyr Phe Arg Leu Gly Ile Lys Met
145                 150                 155                 160 
Gly Lys Gln Gly Ile Ile Asn Lys Glu Gly Tyr Leu Glu Asp Ser Pro
                165                 170                 175     
Gln Pro Val Thr Met Glu Lys Val Val Lys Gln Ser Tyr Glu Phe Ser
            180                 185                 190         
Asn Ser Asn Lys Asn Leu Glu Tyr Thr Glu Cys Asp Thr Phe Arg Ser
        195                 200                 205             
Thr Phe His Ser Lys Ser Thr Leu Ser Glu Pro Gln Asn Asn Ser Ala
    210                 215                 220                 
Glu Gly Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu Ser Lys
225                 230                 235                 240 
Lys Ser Val Ile Lys Ser Glu Arg Ile Asn Gly Gly Lys Lys Leu Leu
                245                 250                 255     
Asn Ser Asn Lys Ser Gly Ala Ala Phe Asn Gln Ser Lys Ser Leu Thr
            260                 265                 270         
Leu Pro Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser Glu Cys
        275                 280                 285             
Gly Lys Ala Phe Gly Lys Gln Ser Ile Leu Ser Arg His Trp Arg Ile
    290                 295                 300                 
His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Thr Phe
305                 310                 315                 320 
Ser His Gly Ser Ser Leu Thr Arg His Gln Ile Ser His Ser Gly Glu
                325                 330                 335     
Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His Gly Ser
            340                 345                 350         
Ser Leu Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro Tyr Glu
        355                 360                 365             
Cys Met Asn Cys Gly Lys Ser Phe Ser Arg Val Ser Leu Leu Ile Gln
    370                 375                 380                 
His Leu Arg Ile His Thr Gln Glu Lys Arg Tyr Glu Cys Arg Ile Cys
385                 390                 395                 400 
Gly Lys Ala Phe Ile His Ser Ser Ser Leu Ile His His Gln Lys Ser
                405                 410                 415     
His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Ala Phe
            420                 425                 430         
Cys Cys Ser Ser His Leu Thr Gln His Gln Arg Ile His Ser Met Lys
        435                 440                 445             
Lys Lys Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser Phe Ser
    450                 455                 460                 
Phe Leu Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro Phe Glu
465                 470                 475                 480 
Val
    


<210> 8193
<211> 411
<212> PRT
<213> Homo sapiens

<400> 8193
Met Ser Gln Val Thr Phe Ser Asp Val Ala Ile Asp Phe Ser His Glu
 1               5                  10                  15      
Glu Trp Ala Cys Leu Asp Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val
            20                  25                  30          
Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Gly Leu Ser Val Thr
        35                  40                  45              
Lys Pro Tyr Val Ile Met Leu Leu Glu Asp Gly Lys Glu Pro Trp Met
    50                  55                  60                  
Met Glu Lys Lys Leu Ser Lys Asp Trp Glu Ser Arg Trp Glu Asn Lys
65                  70                  75                  80  
Glu Leu Ser Thr Lys Lys Asp Ile Tyr Asp Glu Asp Ser Pro Gln Pro
                85                  90                  95      
Val Thr Met Glu Lys Val Val Lys Gln Ser Tyr Glu Phe Ser Asn Ser
            100                 105                 110         
Asn Lys Asn Leu Glu Tyr Thr Glu Cys Asp Thr Phe Arg Ser Thr Phe
        115                 120                 125             
His Ser Lys Ser Thr Leu Ser Glu Pro Gln Asn Asn Ser Ala Glu Gly
    130                 135                 140                 
Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu Ser Lys Lys Ser
145                 150                 155                 160 
Val Ile Lys Ser Glu Arg Ile Asn Gly Gly Lys Lys Leu Leu Asn Ser
                165                 170                 175     
Asn Lys Ser Gly Ala Ala Phe Asn Gln Ser Lys Ser Leu Thr Leu Pro
            180                 185                 190         
Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser Glu Cys Gly Lys
        195                 200                 205             
Ala Phe Gly Lys Gln Ser Ile Leu Ser Arg His Trp Arg Ile His Thr
    210                 215                 220                 
Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Thr Phe Ser His
225                 230                 235                 240 
Gly Ser Ser Leu Thr Arg His Gln Ile Ser His Ser Gly Glu Lys Pro
                245                 250                 255     
Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His Gly Ser Ser Leu
            260                 265                 270         
Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Met
        275                 280                 285             
Asn Cys Gly Lys Ser Phe Ser Arg Val Ser Leu Leu Ile Gln His Leu
    290                 295                 300                 
Arg Ile His Thr Gln Glu Lys Arg Tyr Glu Cys Arg Ile Cys Gly Lys
305                 310                 315                 320 
Ala Phe Ile His Ser Ser Ser Leu Ile His His Gln Lys Ser His Thr
                325                 330                 335     
Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Ala Phe Cys Cys
            340                 345                 350         
Ser Ser His Leu Thr Gln His Gln Arg Ile His Ser Met Lys Lys Lys
        355                 360                 365             
Tyr Glu Cys His Lys Cys Leu Lys Gly Phe Ser Ser Phe Ser Phe Leu
    370                 375                 380                 
Gly Gln His Gln Ser Ile His Thr Gly Glu Lys Pro Leu Lys Phe Arg
385                 390                 395                 400 
Asn Ala Gly Asn Pro Ser Thr Ser Leu Asn His
                405                 410     


<210> 8194
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 8194
Met Ala Lys Ile Ala Lys Thr His Glu Asp Ile Glu Ala Gln Ile Arg
 1               5                  10                  15      
Glu Ile Gln Gly Lys Lys Ala Ala Leu Asp Glu Ala Gln Gly Val Gly
            20                  25                  30          
Leu Asp Ser Thr Gly Tyr Tyr Asp Gln Glu Ile Tyr Gly Gly Ser Asp
        35                  40                  45              
Ser Arg Phe Ala Gly Tyr Val Thr Ser Ile Ala Ala Thr Glu Leu Glu
    50                  55                  60                  
Asp Asp Asp Asp Asp Tyr Ser Ser Ser Thr Ser Leu Leu Gly Gln Lys
65                  70                  75                  80  
Lys Pro Gly Tyr His Ala Pro Val Ala Leu Leu Asn Asp Ile Pro Gln
                85                  90                  95      
Ser Thr Glu Gln Tyr Asp Pro Phe Ala Glu His Arg Pro Pro Lys Ile
            100                 105                 110         
Ala Asp Arg Glu Asp Glu Tyr Lys Lys His Arg Arg Thr Met Ile Ile
        115                 120                 125             
Ser Pro Glu Arg Leu Asp Pro Phe Ala Asp Gly Gly Lys Thr Pro Asp
    130                 135                 140                 
Pro Lys Met Asn Val Arg Thr Tyr Met Asp Val Met Arg Glu Gln His
145                 150                 155                 160 
Leu Thr Lys Glu Glu Arg Glu Ile Arg Gln Gln Leu Ala Glu Lys Ala
                165                 170                 175     
Lys Ala Gly Glu Leu Lys Val Val Asn Gly Ala Ala Ala Ser Gln Pro
            180                 185                 190         
Pro Ser Lys Arg Lys Arg Arg Trp Asp Gln Thr Ala Asp Gln Thr Pro
        195                 200                 205             
Gly Ala Thr Pro Lys Lys Leu Ser Ser Trp Asp Gln Ala Glu Thr Pro
    210                 215                 220                 
Gly His Thr Pro Ser Leu Arg Trp Asp Glu Thr Pro Gly Arg Ala Lys
225                 230                 235                 240 
Gly Ser Glu Thr Pro Gly Ala Thr Pro Gly Ser Lys Ile Trp Asp Pro
                245                 250                 255     
Thr Pro Ser His Thr Pro Ala Gly Ala Ala Thr Pro Gly Arg Gly Asp
            260                 265                 270         
Thr Pro Gly His Ala Thr Pro Gly His Gly Gly Ala Thr Ser Ser Ala
        275                 280                 285             
Arg Lys Asn Arg Trp Asp Glu Thr Pro Lys Thr Glu Arg Asp Thr Pro
    290                 295                 300                 
Gly His Gly Ser Gly Trp Ala Glu Thr Pro Arg Thr Asp Arg Gly Gly
305                 310                 315                 320 
Asp Ser Ile Gly Glu Thr Pro Thr Pro Gly Ala Ser Lys Arg Lys Ser
                325                 330                 335     
Arg Trp Asp Glu Thr Pro Ala Ser Gln Met Gly Gly Ser Thr Pro Val
            340                 345                 350         
Leu Thr Pro Gly Lys Thr Pro Ile Gly Thr Pro Ala Met Asn Met Ala
        355                 360                 365             
Thr Pro Thr Pro Gly His Ile Met Ser Met Thr Pro Glu Gln Leu Gln
    370                 375                 380                 
Ala Trp Arg Trp Glu Arg Glu Ile Asp Glu Arg Asn Arg Pro Leu Ser
385                 390                 395                 400 
Asp Glu Glu Leu Asp Ala Met Phe Pro Glu Gly Tyr Lys Val Leu Pro
                405                 410                 415     
Pro Pro Ala Gly Tyr Val Pro Ile Arg Thr Pro Ala Arg Lys Leu Thr
            420                 425                 430         
Ala Thr Pro Thr Pro Leu Gly Gly Met Thr Gly Phe His Met Gln Thr
        435                 440                 445             
Glu Asp Arg Thr Met Lys Ser Val Asn Asp Gln Pro Ser Gly Asn Leu
    450                 455                 460                 
Pro Phe Leu Lys Pro Asp Asp Ile Gln Tyr Phe Asp Lys Leu Leu Val
465                 470                 475                 480 
Asp Val Asp Glu Ser Thr Leu Ser Pro Glu Glu Gln Lys Glu Arg Lys
                485                 490                 495     
Ile Met Lys Leu Leu Leu Lys Ile Lys Asn Gly Thr Pro Pro Met Arg
            500                 505                 510         
Lys Ala Ala Leu Arg Gln Ile Thr Asp Lys Ala Arg Glu Phe Gly Ala
        515                 520                 525             
Gly Pro Leu Phe Asn Gln Ile Leu Pro Leu Leu Met Ser Pro Thr Leu
    530                 535                 540                 
Glu Asp Gln Glu Arg His Leu Leu Val Lys Val Ile Asp Arg Ile Leu
545                 550                 555                 560 
Tyr Lys Leu Asp Asp Leu Val Arg Pro Tyr Val His Lys Ile Leu Val
                565                 570                 575     
Val Ile Glu Pro Leu Leu Ile Asp Glu Asp Tyr Tyr Ala Arg Val Glu
            580                 585                 590         
Gly Leu Glu Ile Ile Ser Asn Leu Ala Lys Ala Ala Gly Leu Ala Thr
        595                 600                 605             
Met Ile Ser Thr Met Arg Pro Asp Ile Asp Asn Met Asp Glu Tyr Val
    610                 615                 620                 
Arg Asn Thr Thr Ala Arg Ala Phe Ala Val Val Ala Ser Ala Leu Gly
625                 630                 635                 640 
Ile Pro Ser Leu Leu Pro Phe Leu Lys Ala Val Cys Lys Ser Lys Lys
                645                 650                 655     
Ser Trp Gln Ala Arg His Thr Gly Ile Lys Ile Val Gln Gln Ile Ala
            660                 665                 670         
Ile Leu Met Gly Cys Ala Ile Leu Pro His Leu Arg Ser Leu Val Glu
        675                 680                 685             
Ile Ile Glu His Gly Leu Val Asp Glu Gln Gln Lys Val Arg Thr Ile
    690                 695                 700                 
Ser Ala Leu Ala Ile Ala Ala Leu Ala Glu Ala Ala Thr Pro Tyr Gly
705                 710                 715                 720 
Ile Glu Ser Phe Asp Ser Val Leu Lys Pro Leu Trp Lys Gly Ile Arg
                725                 730                 735     
Gln His Arg Gly Lys Gly Leu Ala Ala Phe Leu Lys Ala Ile Gly Tyr
            740                 745                 750         
Leu Ile Pro Leu Met Asp Ala Glu Tyr Ala Asn Tyr Tyr Thr Arg Glu
        755                 760                 765             
Val Met Leu Ile Leu Ile Arg Glu Phe Gln Ser Pro Asp Glu Glu Met
    770                 775                 780                 
Lys Lys Ile Val Leu Lys Val Val Lys Gln Cys Cys Gly Thr Asp Gly
785                 790                 795                 800 
Val Glu Ala Asn Tyr Ile Lys Thr Glu Ile Leu Pro Pro Phe Phe Lys
                805                 810                 815     
His Phe Trp Gln His Arg Met Ala Leu Asp Arg Arg Asn Tyr Arg Gln
            820                 825                 830         
Leu Val Asp Thr Thr Val Glu Leu Ala Asn Lys Val Gly Ala Ala Glu
        835                 840                 845             
Ile Ile Ser Arg Ile Val Asp Asp Leu Lys Asp Glu Ala Glu Gln Tyr
    850                 855                 860                 
Arg Lys Met Val Met Glu Thr Ile Glu Lys Ile Met Gly Asn Leu Gly
865                 870                 875                 880 
Ala Ala Asp Ile Asp His Lys Leu Glu Glu Gln Leu Ile Asp Gly Ile
                885                 890                 895     
Leu Tyr Ala Phe Gln Glu Gln Thr Thr Glu Asp Ser Val Met Leu Asn
            900                 905                 910         
Gly Phe Gly Thr Val Val Asn Ala Leu Gly Lys Arg Val Lys Pro Tyr
        915                 920                 925             
Leu Pro Gln Ile Cys Gly Thr Val Leu Trp Arg Leu Asn Asn Lys Ser
    930                 935                 940                 
Ala Lys Val Arg Gln Gln Ala Ala Asp Leu Ile Ser Arg Thr Ala Val
945                 950                 955                 960 
Val Met Lys Thr Cys Gln Glu Glu Lys Leu Met Gly His Leu Gly Val
                965                 970                 975     
Val Leu Tyr Glu Tyr Leu Gly Glu Glu Tyr Pro Glu Val Leu Gly Ser
            980                 985                 990         
Ile Leu Gly Ala Leu Lys Ala Ile Val Asn Val Ile Gly Met His Lys
        995                 1000                1005            
Met Thr Pro Pro Ile Lys Asp Leu Leu Pro Arg Leu Thr Pro Ile Leu
    1010                1015                1020                
Lys Asn Arg His Glu Lys Val Gln Glu Asn Cys Ile Asp Leu Val Gly
1025                1030                1035                1040
Arg Ile Ala Asp Arg Gly Ala Glu Tyr Val Ser Ala Arg Glu Trp Met
                1045                1050                1055    
Arg Ile Cys Phe Glu Leu Leu Glu Leu Leu Lys Ala His Lys Lys Ala
            1060                1065                1070        
Ile Arg Arg Ala Thr Val Asn Thr Phe Gly Tyr Ile Ala Lys Ala Ile
        1075                1080                1085            
Gly Pro His Asp Val Leu Ala Thr Leu Leu Asn Asn Leu Lys Val Gln
    1090                1095                1100                
Glu Arg Gln Asn Arg Val Cys Thr Thr Val Ala Ile Ala Ile Val Ala
1105                1110                1115                1120
Glu Thr Cys Ser Pro Phe Thr Val Leu Pro Ala Leu Met Asn Glu Tyr
                1125                1130                1135    
Arg Val Pro Glu Leu Asn Val Gln Asn Gly Val Leu Lys Ser Leu Ser
            1140                1145                1150        
Phe Leu Phe Glu Tyr Ile Gly Glu Met Gly Lys Asp Tyr Ile Tyr Ala
        1155                1160                1165            
Val Thr Pro Leu Leu Glu Asp Ala Leu Met Asp Arg Asp Leu Val His
    1170                1175                1180                
Arg Gln Thr Ala Ser Ala Val Val Gln His Met Ser Leu Gly Val Tyr
1185                1190                1195                1200
Gly Phe Gly Cys Glu Asp Ser Leu Asn His Leu Leu Asn Tyr Val Trp
                1205                1210                1215    
Pro Asn Val Phe Glu Thr Ser Pro His Val Ile Gln Ala Val Met Gly
            1220                1225                1230        
Ala Leu Glu Gly Leu Arg Val Ala Ile Gly Pro Cys Arg Met Leu Gln
        1235                1240                1245            
Tyr Cys Leu Gln Gly Leu Phe His Pro Ala Arg Lys Val Arg Asp Val
    1250                1255                1260                
Tyr Trp Lys Ile Tyr Asn Ser Ile Tyr Ile Gly Ser Gln Asp Ala Leu
1265                1270                1275                1280
Ile Ala His Tyr Pro Arg Ile Tyr Asn Asp Asp Lys Asn Thr Tyr Ile
                1285                1290                1295    
Arg Tyr Glu Leu Asp Tyr Ile Leu
            1300                


<210> 8195
<211> 280
<212> PRT
<213> Homo sapiens

<400> 8195
Met Arg Thr Arg Lys Val Leu Ala Asp His Pro Val Gln Arg Leu Ser
 1               5                  10                  15      
Asn Gly Lys Cys Glu Arg Thr Thr Glu Ser His Gly Phe Phe Ser Glu
            20                  25                  30          
Leu Leu Phe Ser Ser Asp Ala Ile Phe Tyr Lys Thr Ser Cys Glu Gly
        35                  40                  45              
Val Glu Asp Gly Met Tyr Ser His Pro Asn Lys Leu Lys Met Leu Thr
    50                  55                  60                  
Asn Pro Ser Thr Ala Asn Ser Asn Leu Leu Leu His Gln Ser Asp Gln
65                  70                  75                  80  
His Leu Ile Ser Ser Ser Leu Glu Phe Ile Gly Leu Phe Gly Arg Ser
                85                  90                  95      
Asp Leu Ala Ile Ala Leu Tyr Val Leu Leu Ile Gly Ser Cys Pro Gly
            100                 105                 110         
Gly Ile Ser Ser Glu Ala Ser Tyr Trp Asn Thr Thr Met Thr Val Gln
        115                 120                 125             
Lys Arg Tyr Thr Phe Lys Pro Ser Glu Leu Thr Asn Tyr Arg Ala Lys
    130                 135                 140                 
Gln Asn His Pro Lys Arg Ser Arg Tyr Cys Asp Met Glu Val Val Gly
145                 150                 155                 160 
Ile Gly Thr Ser Val Ser Pro Pro Gln Ser Ile Gly Ala Asp Ala Arg
                165                 170                 175     
Leu Gln Glu Asn Arg Ser Gly His Arg Leu Phe Ala His Ser Gly Gly
            180                 185                 190         
Val Lys Gln Leu Thr Asp Gln Met Gln Pro Ala Ala Leu Cys Gln Pro
        195                 200                 205             
Glu Asp Glu Gly Asp Thr Cys Trp Gln Asp Arg Gly Ser Ser Ser Cys
    210                 215                 220                 
Phe Ser Cys Tyr Ser Leu Arg Ser Ser Gly His Val Ser His Ile Thr
225                 230                 235                 240 
Cys Leu Ser Lys Lys Ser Ser Ser Tyr Val Glu Arg Arg Ser Ile Asn
                245                 250                 255     
Pro Lys Glu His Lys Gly Glu Arg Glu Gln Tyr Thr Leu Tyr Met Cys
            260                 265                 270         
Phe Ile Leu Gln Ser Met Pro Glu
        275                 280 


<210> 8196
<211> 280
<212> PRT
<213> Homo sapiens

<400> 8196
Met Arg Thr Arg Lys Val Leu Ala Asp His Pro Val Gln Arg Leu Ser
 1               5                  10                  15      
Asn Gly Lys Cys Glu Arg Thr Thr Glu Leu His Gly Phe Phe Ser Glu
            20                  25                  30          
Leu Leu Phe Ser Ser Asp Ala Ile Phe Tyr Lys Thr Ser Cys Glu Gly
        35                  40                  45              
Val Glu Asp Gly Met Tyr Ser His Pro Asn Lys Leu Lys Met Leu Thr
    50                  55                  60                  
Asn Pro Ser Thr Ala Asn Ser Asn Leu Leu Leu His Gln Ser Asp Gln
65                  70                  75                  80  
His Leu Ile Ser Ser Ser Leu Glu Phe Ile Gly Leu Phe Gly Leu Ser
                85                  90                  95      
Asp Leu Ala Ile Ala Leu Tyr Val Leu Leu Ile Gly Ser Cys Pro Gly
            100                 105                 110         
Gly Ile Ser Ser Glu Ala Ser Tyr Trp Asn Thr Thr Met Thr Val Gln
        115                 120                 125             
Lys Arg Tyr Thr Phe Lys Pro Ser Glu Leu Thr Asn Tyr Arg Ala Lys
    130                 135                 140                 
Gln Asn His Pro Lys Arg Ser Arg Tyr Cys Asp Met Glu Val Val Gly
145                 150                 155                 160 
Ile Gly Thr Ser Val Ser Pro Pro Gln Ser Ile Gly Ala Asp Ala Arg
                165                 170                 175     
Leu Gln Glu Asn Arg Ser Gly His Arg Leu Phe Ala His Ser Gly Gly
            180                 185                 190         
Val Lys Gln Leu Thr Asp Gln Met Gln Pro Ala Ala Leu Cys Gln Pro
        195                 200                 205             
Glu Asp Glu Gly Asp Thr Cys Trp Gln Asp Arg Gly Ser Ser Ser Cys
    210                 215                 220                 
Phe Ser Cys Tyr Ser Leu Arg Ser Ser Gly His Val Ser His Ile Thr
225                 230                 235                 240 
Cys Leu Ser Lys Lys Ser Ser Ser Tyr Val Glu Arg Arg Ser Ile Asn
                245                 250                 255     
Pro Lys Glu His Lys Gly Glu Arg Glu Gln Tyr Thr Leu Tyr Met Cys
            260                 265                 270         
Phe Ile Leu Gln Ser Met Pro Glu
        275                 280 


<210> 8197
<211> 1266
<212> PRT
<213> Homo sapiens

<400> 8197
Met Ser Asn Lys Met Leu Gln Gln Val Pro Glu Asn Ile Asn Phe Pro
 1               5                  10                  15      
Ala Glu Glu Glu Lys Ile Leu Glu Phe Trp Thr Glu Phe Asn Cys Phe
            20                  25                  30          
Gln Glu Cys Leu Lys Gln Ser Lys His Lys Pro Lys Phe Thr Phe Tyr
        35                  40                  45              
Asp Gly Pro Pro Phe Ala Thr Gly Leu Pro His Tyr Gly His Ile Leu
    50                  55                  60                  
Ala Gly Thr Ile Lys Asp Ile Val Thr Arg Tyr Ala His Gln Ser Gly
65                  70                  75                  80  
Phe His Val Asp Arg Arg Phe Gly Trp Asp Cys His Gly Leu Pro Val
                85                  90                  95      
Glu Tyr Glu Ile Asp Lys Thr Leu Gly Ile Arg Gly Pro Glu Asp Val
            100                 105                 110         
Ala Lys Met Gly Ile Thr Glu Tyr Asn Asn Gln Cys Arg Ala Ile Val
        115                 120                 125             
Met Arg Tyr Ser Ala Glu Trp Lys Ser Thr Val Ser Arg Leu Gly Arg
    130                 135                 140                 
Trp Ile Asp Phe Asp Asn Asp Tyr Lys Thr Leu Tyr Pro Gln Phe Met
145                 150                 155                 160 
Glu Ser Val Trp Trp Val Phe Lys Gln Leu Tyr Asp Lys Gly Leu Val
                165                 170                 175     
Tyr Arg Gly Val Lys Val Met Pro Phe Ser Thr Ala Cys Asn Thr Pro
            180                 185                 190         
Leu Ser Asn Phe Glu Ser His Gln Asn Tyr Lys Asp Val Gln Asp Pro
        195                 200                 205             
Ser Val Phe Val Thr Phe Pro Leu Glu Glu Asp Glu Thr Val Ser Leu
    210                 215                 220                 
Val Ala Trp Thr Thr Thr Pro Trp Thr Leu Pro Ser Asn Leu Ala Val
225                 230                 235                 240 
Cys Val Asn Pro Glu Met Gln Tyr Val Lys Ile Lys Asp Val Ala Arg
                245                 250                 255     
Gly Arg Leu Leu Ile Leu Met Glu Ala Arg Leu Ser Ala Leu Tyr Lys
            260                 265                 270         
Leu Glu Ser Asp Tyr Glu Ile Leu Glu Arg Phe Pro Gly Ala Tyr Leu
        275                 280                 285             
Lys Gly Lys Lys Tyr Arg Pro Leu Phe Asp Tyr Phe Leu Lys Cys Lys
    290                 295                 300                 
Glu Asn Gly Ala Phe Thr Val Leu Val Asp Asn Tyr Val Lys Glu Glu
305                 310                 315                 320 
Glu Gly Thr Gly Val Val His Gln Ala Pro Tyr Phe Gly Ala Glu Asp
                325                 330                 335     
Tyr Arg Val Cys Met Asp Phe Asn Ile Ile Arg Lys Asp Ser Leu Pro
            340                 345                 350         
Val Cys Pro Val Asp Ala Ser Gly Cys Phe Thr Thr Glu Val Thr Asp
        355                 360                 365             
Phe Ala Gly Gln Tyr Val Lys Asp Ala Asp Lys Ser Ile Ile Arg Thr
    370                 375                 380                 
Leu Lys Glu Gln Gly Arg Leu Leu Val Ala Thr Thr Phe Thr His Ser
385                 390                 395                 400 
Tyr Pro Phe Cys Trp Arg Ser Asp Thr Pro Leu Ile Tyr Lys Ala Val
                405                 410                 415     
Pro Ser Trp Phe Val Arg Val Glu Asn Met Val Asp Gln Leu Leu Arg
            420                 425                 430         
Asn Asn Asp Leu Cys Tyr Trp Val Pro Glu Leu Val Arg Glu Lys Arg
        435                 440                 445             
Phe Gly Asn Trp Leu Lys Asp Ala Arg Asp Trp Thr Ile Ser Arg Asn
    450                 455                 460                 
Arg Tyr Trp Gly Thr Pro Ile Pro Leu Trp Val Ser Asp Asp Phe Glu
465                 470                 475                 480 
Glu Val Val Cys Ile Gly Ser Val Ala Glu Leu Glu Glu Leu Ser Gly
                485                 490                 495     
Ala Lys Ile Ser Asp Leu His Arg Glu Ser Val Asp His Leu Thr Ile
            500                 505                 510         
Pro Ser Arg Cys Gly Lys Gly Ser Leu His Arg Ile Ser Glu Val Phe
        515                 520                 525             
Asp Cys Trp Phe Glu Ser Gly Ser Met Pro Tyr Ala Gln Val His Tyr
    530                 535                 540                 
Pro Phe Glu Asn Lys Arg Glu Phe Glu Asp Ala Phe Pro Ala Asp Phe
545                 550                 555                 560 
Ile Ala Glu Gly Ile Asp Gln Thr Arg Gly Trp Phe Tyr Thr Leu Leu
                565                 570                 575     
Val Leu Ala Thr Ala Leu Phe Gly Gln Pro Pro Phe Lys Asn Val Ile
            580                 585                 590         
Val Asn Gly Leu Val Leu Ala Ser Asp Gly Gln Lys Met Ser Lys Arg
        595                 600                 605             
Lys Lys Asn Tyr Pro Asp Pro Val Ser Ile Ile Gln Lys Tyr Gly Ala
    610                 615                 620                 
Asp Ala Leu Arg Leu Tyr Leu Ile Asn Ser Pro Val Val Arg Ala Glu
625                 630                 635                 640 
Asn Leu Arg Phe Lys Glu Glu Gly Val Arg Asp Val Leu Lys Asp Val
                645                 650                 655     
Leu Leu Pro Trp Tyr Asn Ala Tyr Arg Phe Leu Ile Gln Asn Val Leu
            660                 665                 670         
Arg Leu Gln Lys Glu Glu Glu Ile Glu Phe Leu Tyr Asn Glu Asn Thr
        675                 680                 685             
Val Arg Glu Ser Pro Asn Ile Thr Asp Arg Trp Ile Leu Ser Phe Met
    690                 695                 700                 
Gln Ser Leu Ile Gly Phe Phe Glu Thr Glu Met Ala Ala Tyr Arg Leu
705                 710                 715                 720 
Tyr Thr Val Val Pro Arg Leu Val Lys Phe Val Asp Ile Leu Thr Asn
                725                 730                 735     
Trp Tyr Val Arg Met Asn Arg Arg Arg Leu Lys Gly Glu Asn Gly Met
            740                 745                 750         
Glu Asp Cys Val Met Ala Leu Glu Thr Leu Phe Ser Val Leu Leu Ser
        755                 760                 765             
Leu Cys Arg Leu Met Ala Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met
    770                 775                 780                 
Tyr Gln Asn Leu Lys Val Leu Ile Asp Pro Val Ser Val Gln Asp Lys
785                 790                 795                 800 
Asp Thr Leu Ser Ile His Tyr Leu Met Leu Pro Arg Val Arg Glu Glu
                805                 810                 815     
Leu Ile Asp Lys Lys Thr Glu Ser Ala Val Ser Gln Met Gln Ser Val
            820                 825                 830         
Ile Glu Leu Gly Arg Val Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys
        835                 840                 845             
Tyr Pro Leu Lys Glu Ile Val Val Ile His Gln Asp Pro Glu Ala Leu
    850                 855                 860                 
Lys Asp Ile Lys Ser Leu Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val
865                 870                 875                 880 
Arg Lys Val Thr Leu Ser Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu
                885                 890                 895     
Arg Ala Glu Pro Asp His Met Val Leu Gly Lys Arg Leu Lys Gly Ala
            900                 905                 910         
Phe Lys Ala Val Met Thr Ser Ile Lys Gln Leu Ser Ser Glu Glu Leu
        915                 920                 925             
Glu Gln Phe Gln Lys Thr Gly Thr Ile Val Val Glu Gly His Glu Leu
    930                 935                 940                 
His Asp Glu Asp Ile Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly
945                 950                 955                 960 
Gly Thr Ala Gln Phe Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu
                965                 970                 975     
Leu Asp Val Thr Pro Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg
            980                 985                 990         
Glu Val Ile Asn Arg Ile Gln Lys Leu Arg Lys Lys Cys Asn Leu Val
        995                 1000                1005            
Pro Thr Asp Glu Ile Thr Val Tyr Tyr Lys Ala Lys Ser Glu Gly Thr
    1010                1015                1020                
Tyr Leu Asn Ser Val Ile Glu Ser His Thr Glu Phe Ile Phe Thr Thr
1025                1030                1035                1040
Ile Lys Ala Pro Leu Lys Pro Tyr Pro Val Ser Pro Ser Asp Lys Val
                1045                1050                1055    
Leu Ile Gln Glu Lys Thr Gln Leu Lys Gly Ser Glu Leu Glu Ile Thr
            1060                1065                1070        
Leu Thr Arg Gly Ser Ser Leu Pro Gly Pro Ala Cys Ala Tyr Val Asn
        1075                1080                1085            
Leu Asn Ile Cys Ala Asn Gly Ser Glu Gln Gly Gly Val Leu Leu Leu
    1090                1095                1100                
Glu Asn Pro Lys Gly Asp Asn Arg Leu Asp Leu Leu Lys Leu Lys Ser
1105                1110                1115                1120
Val Val Thr Ser Ile Phe Gly Val Lys Asn Thr Glu Leu Ala Val Phe
                1125                1130                1135    
His Asp Glu Thr Glu Ile Gln Asn Gln Thr Asp Leu Leu Ser Leu Ser
            1140                1145                1150        
Gly Lys Thr Leu Cys Val Thr Ala Gly Ser Ala Pro Ser Leu Ile Asn
        1155                1160                1165            
Ser Ser Ser Thr Leu Leu Cys Gln Tyr Ile Asn Leu Gln Leu Leu Asn
    1170                1175                1180                
Ala Lys Pro Gln Glu Cys Leu Met Gly Thr Val Gly Thr Leu Leu Leu
1185                1190                1195                1200
Glu Asn Pro Leu Gly Gln Asn Gly Leu Thr His Gln Gly Leu Leu Tyr
                1205                1210                1215    
Glu Ala Ala Lys Val Phe Gly Leu Arg Ser Arg Lys Leu Lys Leu Phe
            1220                1225                1230        
Leu Asn Glu Thr Gln Thr Gln Glu Ile Thr Glu Asp Ile Pro Val Lys
        1235                1240                1245            
Thr Leu Asn Met Lys Thr Val Tyr Val Ser Val Leu Pro Thr Thr Ala
    1250                1255                1260                
Asp Phe
1265    


<210> 8198
<211> 101
<212> PRT
<213> Homo sapiens

<400> 8198
Pro Gly Glu Ala Lys Met Pro Ser Lys Gly Lys Asp Lys Lys Lys Gly
 1               5                  10                  15      
Lys Ser Lys Gly Lys Asp Thr Lys Lys Leu Ile Lys Thr Asp Glu Ser
            20                  25                  30          
Val Val Asp Arg Ala Lys Ala Asn Ala Ser Leu Trp Glu Ala Arg Leu
        35                  40                  45              
Glu Val Thr Glu Leu Ser Arg Ile Lys Tyr Arg Asp Thr Ser Arg Ile
    50                  55                  60                  
Leu Ala Lys Ser Asn Glu Asp Leu Lys Lys Lys Gln Cys Lys Met Glu
65                  70                  75                  80  
Lys Asp Ile Met Ser Val Leu Ser Tyr Leu Lys Lys Gln Asp Gln Glu
                85                  90                  95      
Lys Asp Asn Met Val
            100     


<210> 8199
<211> 602
<212> PRT
<213> Homo sapiens

<400> 8199
Met Glu Arg Ser Leu His Arg Val Ser Leu Gly Ser Arg Arg Ala His
 1               5                  10                  15      
Pro Asp Leu Ser Phe Tyr Leu Thr Thr Phe Gly Gln Leu Arg Leu Ser
            20                  25                  30          
Ile Asp Ala Gln Asp Arg Val Leu Leu Leu His Ile Ile Glu Gly Lys
        35                  40                  45              
Gly Leu Ile Ser Lys Gln Pro Gly Thr Cys Asp Pro Tyr Val Lys Ile
    50                  55                  60                  
Ser Leu Ile Pro Glu Asp Ser Arg Leu Arg His Gln Lys Thr Gln Thr
65                  70                  75                  80  
Val Pro Asp Cys Arg Asp Pro Ala Phe His Glu His Phe Ser Phe Pro
                85                  90                  95      
Val Gln Glu Glu Asp Asp Gln Lys Arg Leu Leu Val Thr Val Trp Asn
            100                 105                 110         
Arg Ala Ser Gln Ser Arg Gln Ser Gly Leu Ile Gly Cys Met Ser Phe
        115                 120                 125             
Gly Val Lys Ser Leu Leu Thr Pro Asp Lys Glu Ile Ser Gly Trp Tyr
    130                 135                 140                 
Tyr Leu Leu Gly Glu His Leu Gly Arg Thr Lys His Leu Lys Val Ala
145                 150                 155                 160 
Arg Arg Arg Leu Arg Pro Leu Arg Asp Pro Leu Leu Arg Met Pro Gly
                165                 170                 175     
Gly Gly Asp Thr Glu Asn Gly Lys Lys Leu Lys Ile Thr Ile Pro Arg
            180                 185                 190         
Gly Lys Asp Gly Phe Gly Phe Thr Ile Cys Cys Asp Ser Pro Val Arg
        195                 200                 205             
Val Gln Ala Val Asp Ser Gly Gly Pro Ala Glu Arg Ala Gly Leu Gln
    210                 215                 220                 
Gln Leu Asp Thr Val Leu Gln Leu Asn Glu Arg Pro Val Glu His Trp
225                 230                 235                 240 
Lys Cys Val Glu Leu Ala His Glu Ile Arg Ser Cys Pro Ser Glu Ile
                245                 250                 255     
Ile Leu Leu Val Trp Arg Met Val Pro Gln Val Lys Pro Gly Pro Asp
            260                 265                 270         
Gly Gly Val Leu Arg Arg Ala Ser Cys Lys Ser Thr His Asp Leu Gln
        275                 280                 285             
Ser Pro Pro Asn Lys Arg Glu Lys Asn Cys Thr His Gly Val Gln Ala
    290                 295                 300                 
Arg Pro Glu Gln Arg His Ser Cys His Leu Val Cys Asp Ser Ser Asp
305                 310                 315                 320 
Gly Leu Leu Leu Gly Gly Trp Glu Arg Tyr Thr Glu Val Ala Lys Arg
                325                 330                 335     
Gly Gly Gln His Thr Leu Pro Ala Leu Ser Arg Ala Thr Ala Pro Thr
            340                 345                 350         
Asp Pro Asn Tyr Ile Ile Leu Ala Pro Leu Asn Pro Gly Ser Gln Leu
        355                 360                 365             
Leu Arg Pro Val Tyr Gln Glu Asp Thr Ile Pro Glu Glu Ser Gly Ser
    370                 375                 380                 
Pro Ser Lys Gly Lys Ser Tyr Thr Gly Leu Gly Lys Lys Ser Arg Leu
385                 390                 395                 400 
Met Lys Thr Val Gln Thr Met Lys Gly His Gly Asn Tyr Gln Asn Cys
                405                 410                 415     
Pro Val Val Arg Pro His Ala Thr His Ser Ser Tyr Gly Thr Tyr Val
            420                 425                 430         
Thr Leu Ala Pro Lys Val Leu Val Phe Pro Val Phe Val Gln Pro Leu
        435                 440                 445             
Asp Leu Cys Asn Pro Ala Arg Thr Leu Leu Leu Ser Glu Glu Leu Leu
    450                 455                 460                 
Leu Tyr Glu Gly Arg Asn Lys Ala Ala Glu Val Thr Leu Phe Ala Tyr
465                 470                 475                 480 
Ser Asp Leu Leu Leu Phe Thr Lys Glu Asp Glu Pro Gly Arg Cys Asp
                485                 490                 495     
Val Leu Arg Asn Pro Leu Tyr Leu Gln Ser Val Lys Leu Gln Glu Gly
            500                 505                 510         
Ser Ser Glu Asp Leu Lys Phe Arg Val Leu Tyr Leu Ala Glu Lys Ala
        515                 520                 525             
Glu Cys Leu Phe Thr Leu Glu Ala His Ser Gln Glu Gln Lys Lys Arg
    530                 535                 540                 
Val Cys Trp Cys Leu Ser Glu Asn Ile Ala Lys Gln Gln Gln Leu Ala
545                 550                 555                 560 
Ala Ser Pro Pro Asp Ser Lys Lys Leu His Pro Phe Gly Ser Leu Gln
                565                 570                 575     
Gln Glu Met Gly Pro Val Asn Ser Thr Asn Ala Thr Gln Asp Arg Ser
            580                 585                 590         
Phe Thr Ser Pro Gly Gln Thr Leu Ile Gly
        595                 600         


<210> 8200
<211> 207
<212> PRT
<213> Homo sapiens

<400> 8200
Met Arg Arg Thr Gly Ala Pro Ala Gln Ala Asp Ser Arg Gly Arg Gly
 1               5                  10                  15      
Arg Ala Arg Gly Gly Cys Pro Gly Gly Glu Ala Thr Leu Ser Gln Pro
            20                  25                  30          
Pro Pro Arg Gly Gly Thr Arg Gly Gln Glu Pro Gln Met Lys Glu Thr
        35                  40                  45              
Ile Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg Ile
    50                  55                  60                  
Gly Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg Thr
65                  70                  75                  80  
Ala Thr Ala Asp Asp Lys Lys Leu Gln Phe Ser Leu Lys Lys Leu Gly
                85                  90                  95      
Val Asn Asn Ile Ser Gly Ile Glu Glu Ala Ser Asn Met Phe Thr Asn
            100                 105                 110         
Gln Gly Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu
        115                 120                 125             
Ala Ala Asn Thr Phe Thr Ile Thr Gly His Ala Glu Thr Lys Gln Leu
    130                 135                 140                 
Thr Glu Met Leu Pro Ser Ile Leu Asn Gln Leu Gly Ala Asp Ser Leu
145                 150                 155                 160 
Thr Ser Leu Arg Arg Leu Ala Glu Ala Leu Pro Lys Gln Ser Val Asp
                165                 170                 175     
Gly Lys Ala Pro Leu Ala Thr Gly Glu Asp Asp Asp Asp Glu Val Pro
            180                 185                 190         
Asp Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn
        195                 200                 205         


<210> 8201
<211> 2209
<212> PRT
<213> Homo sapiens

<400> 8201
Met Trp Asn Asp Ile Glu Leu Leu Thr Asn Asp Asp Thr Gly Ser Gly
 1               5                  10                  15      
Tyr Leu Ser Val Gly Ser Arg Lys Glu His Gly Thr Ala Leu Tyr Gln
            20                  25                  30          
Val Asp Leu Leu Val Lys Ile Ser Ser Glu Lys Ala Ser Leu Asn Pro
        35                  40                  45              
Lys Ile Gln Ala Cys Ser Leu Ser Asp Gly Phe Ile Ile Val Ala Asp
    50                  55                  60                  
Gln Ser Val Ile Leu Leu Asp Ser Ile Cys Arg Ser Leu Gln Leu His
65                  70                  75                  80  
Leu Val Phe Asp Thr Glu Val Asp Val Val Gly Leu Cys Gln Glu Gly
                85                  90                  95      
Lys Phe Leu Leu Val Gly Glu Arg Ser Gly Asn Leu His Leu Ile His
            100                 105                 110         
Val Thr Ser Lys Gln Thr Leu Leu Thr Asn Ala Phe Val Gln Lys Ala
        115                 120                 125             
Asn Asp Glu Asn Arg Arg Thr Tyr Gln Asn Leu Val Ile Glu Lys Asp
    130                 135                 140                 
Gly Ser Asn Glu Gly Thr Tyr Tyr Met Leu Leu Leu Thr Tyr Ser Gly
145                 150                 155                 160 
Phe Phe Cys Ile Thr Asn Leu Gln Leu Leu Lys Ile Gln Gln Ala Ile
                165                 170                 175     
Glu Asn Val Asp Phe Ser Thr Ala Lys Lys Leu Gln Gly Gln Ile Lys
            180                 185                 190         
Ser Ser Phe Ile Ser Thr Glu Asn Tyr His Thr Leu Gly Cys Leu Ser
        195                 200                 205             
Leu Val Ala Gly Asp Leu Ala Ser Glu Val Pro Val Ile Ile Gly Gly
    210                 215                 220                 
Thr Gly Asn Cys Ala Phe Ser Lys Trp Glu Pro Asp Ser Ser Lys Lys
225                 230                 235                 240 
Gly Met Thr Val Lys Asn Leu Ile Asp Ala Glu Ile Ile Lys Gly Ala
                245                 250                 255     
Lys Lys Phe Gln Leu Ile Asp Asn Leu Leu Phe Val Leu Asp Thr Asp
            260                 265                 270         
Asn Val Leu Ser Leu Trp Asp Ile Tyr Thr Leu Thr Pro Val Trp Asn
        275                 280                 285             
Trp Pro Ser Leu His Val Glu Glu Phe Leu Leu Thr Thr Glu Ala Asp
    290                 295                 300                 
Ser Pro Ser Ser Val Thr Trp Gln Gly Ile Thr Asn Leu Lys Leu Ile
305                 310                 315                 320 
Ala Leu Thr Ala Ser Ala Asn Lys Lys Met Lys Asn Leu Met Val Tyr
                325                 330                 335     
Ser Leu Pro Thr Met Glu Ile Leu Tyr Ser Leu Glu Val Ser Ser Val
            340                 345                 350         
Ser Ser Leu Val Gln Thr Gly Ile Ser Thr Asp Thr Ile Tyr Leu Leu
        355                 360                 365             
Glu Gly Val Cys Lys Asn Asp Pro Lys Leu Ser Glu Asp Ser Val Ser
    370                 375                 380                 
Val Leu Val Leu Arg Cys Leu Thr Glu Ala Leu Pro Glu Asn Arg Leu
385                 390                 395                 400 
Ser Arg Leu Leu His Lys His Arg Phe Ala Glu Ala Glu Ser Phe Ala
                405                 410                 415     
Ile Gln Phe Gly Leu Asp Val Glu Leu Val Tyr Lys Val Lys Ser Asn
            420                 425                 430         
His Ile Leu Glu Lys Leu Ala Leu Ser Ser Val Asp Ala Ser Glu Gln
        435                 440                 445             
Thr Glu Trp Gln Gln Leu Val Asp Asp Ala Lys Glu Asn Leu His Lys
    450                 455                 460                 
Ile Gln Asp Asp Glu Phe Val Val Asn Tyr Cys Leu Lys Ala Gln Trp
465                 470                 475                 480 
Ile Thr Tyr Glu Thr Thr Gln Glu Met Leu Asn Tyr Ala Lys Thr Arg
                485                 490                 495     
Leu Leu Lys Lys Glu Asp Lys Thr Ala Leu Ile Tyr Ser Asp Gly Leu
            500                 505                 510         
Lys Glu Val Leu Arg Ala His Ala Lys Leu Thr Thr Phe Tyr Gly Ala
        515                 520                 525             
Phe Gly Pro Glu Lys Phe Ser Gly Ser Ser Trp Ile Glu Phe Leu Asn
    530                 535                 540                 
Asn Glu Asp Asp Leu Lys Asp Ile Phe Leu Gln Leu Lys Glu Gly Asn
545                 550                 555                 560 
Leu Val Cys Ala Gln Tyr Leu Trp Leu Arg His Arg Ala Asn Phe Glu
                565                 570                 575     
Ser Arg Phe Asp Val Lys Met Leu Glu Ser Leu Leu Asn Ser Met Ser
            580                 585                 590         
Ala Ser Val Ser Leu Gln Lys Leu Cys Pro Trp Phe Lys Asn Asp Val
        595                 600                 605             
Ile Pro Phe Val Arg Arg Thr Val Pro Glu Gly Gln Ile Ile Leu Ala
    610                 615                 620                 
Lys Trp Leu Glu Gln Ala Ala Arg Asn Leu Glu Leu Thr Asp Lys Ala
625                 630                 635                 640 
Asn Trp Pro Glu Asn Gly Leu Gln Leu Ala Glu Ile Phe Phe Thr Ala
                645                 650                 655     
Glu Lys Thr Asp Glu Leu Gly Leu Ala Ser Ser Trp His Trp Ile Ser
            660                 665                 670         
Leu Lys Asp Tyr Gln Asn Thr Glu Glu Val Cys Gln Leu Arg Thr Leu
        675                 680                 685             
Val Asn Asn Leu Arg Glu Leu Ile Thr Leu His Arg Lys Tyr Asn Cys
    690                 695                 700                 
Lys Leu Ala Leu Ser Asp Phe Glu Lys Glu Asn Thr Thr Thr Ile Val
705                 710                 715                 720 
Phe Arg Met Phe Asp Lys Val Leu Ala Pro Glu Leu Ile Pro Ser Ile
                725                 730                 735     
Leu Glu Lys Phe Ile Arg Val Tyr Met Arg Glu His Asp Leu Gln Glu
            740                 745                 750         
Glu Glu Leu Leu Leu Leu Tyr Ile Glu Asp Leu Leu Asn Arg Cys Ser
        755                 760                 765             
Ser Lys Ser Thr Ser Leu Phe Glu Thr Ala Trp Glu Ala Lys Ala Met
    770                 775                 780                 
Ala Val Ile Ala Cys Leu Ser Asp Thr Asp Leu Ile Phe Asp Ala Val
785                 790                 795                 800 
Leu Lys Ile Met Tyr Ala Ala Val Val Pro Trp Ser Ala Ala Val Glu
                805                 810                 815     
Gln Leu Val Lys Gln His Leu Glu Met Asp His Pro Lys Val Lys Leu
            820                 825                 830         
Leu Gln Glu Ser Tyr Lys Leu Met Glu Met Lys Lys Leu Leu Arg Gly
        835                 840                 845             
Tyr Gly Ile Arg Glu Val Asn Leu Leu Asn Lys Glu Ile Met Arg Val
    850                 855                 860                 
Val Arg Tyr Ile Leu Lys Gln Asp Val Pro Ser Ser Leu Glu Asp Ala
865                 870                 875                 880 
Leu Lys Val Ala Gln Ala Phe Met Leu Ser Asp Asp Glu Ile Tyr Ser
                885                 890                 895     
Leu Arg Ile Ile Asp Leu Ile Asp Arg Glu Gln Gly Glu Asp Cys Leu
            900                 905                 910         
Leu Leu Leu Lys Ser Leu Pro Pro Ala Glu Ala Glu Lys Thr Ala Glu
        915                 920                 925             
Arg Val Ile Ile Trp Ala Arg Leu Ala Leu Gln Glu Glu Pro Asp His
    930                 935                 940                 
Ser Lys Glu Gly Lys Ala Trp Arg Met Ser Val Ala Lys Thr Ser Val
945                 950                 955                 960 
Asp Ile Leu Lys Ile Leu Cys Asp Ile Gln Lys Asp Asn Leu Gln Lys
                965                 970                 975     
Lys Asp Glu Cys Glu Glu Met Leu Lys Leu Phe Lys Glu Val Ala Ser
            980                 985                 990         
Leu Gln Glu Asn Phe Glu Val Phe Leu Ser Phe Glu Asp Tyr Ser Asn
        995                 1000                1005            
Ser Ser Leu Val Ala Asp Leu Arg Glu Gln His Ile Lys Ala His Glu
    1010                1015                1020                
Val Ala Gln Ala Lys His Lys Pro Gly Ser Thr Pro Glu Pro Ile Ala
1025                1030                1035                1040
Ala Glu Val Arg Ser Pro Ser Met Glu Ser Lys Leu His Arg Gln Ala
                1045                1050                1055    
Leu Ala Leu Gln Met Ser Lys Gln Glu Leu Glu Ala Glu Leu Thr Leu
            1060                1065                1070        
Arg Ala Leu Lys Asp Gly Asn Ile Lys Thr Ala Leu Lys Lys Cys Ser
        1075                1080                1085            
Asp Leu Phe Lys Tyr His Cys Asn Ala Asp Thr Gly Lys Leu Leu Phe
    1090                1095                1100                
Leu Thr Cys Gln Lys Leu Cys Gln Met Leu Ala Asp Asn Val Pro Val
1105                1110                1115                1120
Thr Val Pro Val Gly Leu Asn Leu Pro Ser Met Ile His Asp Leu Ala
                1125                1130                1135    
Ser Gln Ala Ala Thr Ile Cys Ser Pro Asp Phe Leu Leu Asp Ala Leu
            1140                1145                1150        
Glu Leu Cys Lys His Thr Leu Met Ala Val Glu Leu Ser Arg Gln Cys
        1155                1160                1165            
Gln Met Asp Asp Cys Gly Ile Leu Met Lys Ala Ser Phe Gly Thr His
    1170                1175                1180                
Lys Asp Pro Tyr Glu Glu Trp Ser Tyr Ser Asp Phe Phe Ser Glu Asp
1185                1190                1195                1200
Gly Ile Val Leu Glu Ser Gln Met Val Leu Pro Val Ile Tyr Glu Leu
                1205                1210                1215    
Ile Ser Ser Leu Val Pro Leu Ala Glu Ser Lys Arg Tyr Pro Leu Glu
            1220                1225                1230        
Ser Thr Ser Leu Pro Tyr Cys Ser Leu Asn Glu Gly Asp Gly Leu Val
        1235                1240                1245            
Leu Pro Val Ile Asn Ser Ile Ser Ala Leu Leu Gln Asn Leu Gln Glu
    1250                1255                1260                
Ser Ser Gln Trp Glu Leu Ala Leu Arg Phe Val Val Gly Ser Phe Gly
1265                1270                1275                1280
Thr Cys Leu Gln His Ser Val Ser Asn Phe Met Asn Ala Thr Leu Ser
                1285                1290                1295    
Glu Lys Leu Phe Gly Glu Thr Thr Leu Val Lys Ser Arg His Val Val
            1300                1305                1310        
Met Glu Leu Lys Glu Lys Ala Val Ile Phe Ile Arg Glu Asn Ala Thr
        1315                1320                1325            
Thr Leu Leu His Lys Val Phe Asn Cys Arg Leu Val Asp Leu Asp Leu
    1330                1335                1340                
Ala Leu Gly Tyr Cys Thr Leu Leu Pro Gln Lys Asp Val Phe Glu Asn
1345                1350                1355                1360
Leu Trp Lys Leu Ile Asp Lys Ala Trp Gln Asn Tyr Asp Lys Ile Leu
                1365                1370                1375    
Ala Ile Ser Leu Val Gly Ser Glu Leu Ala Ser Leu Tyr Gln Glu Ile
            1380                1385                1390        
Glu Met Gly Leu Lys Phe Arg Glu Leu Ser Thr Asp Ala Gln Trp Gly
        1395                1400                1405            
Ile Arg Leu Gly Lys Leu Gly Ile Ser Phe Gln Pro Val Phe Arg Gln
    1410                1415                1420                
His Phe Leu Thr Lys Lys Asp Leu Ile Lys Ala Leu Val Glu Asn Ile
1425                1430                1435                1440
Asp Met Asp Thr Ser Leu Ile Leu Glu Tyr Cys Ser Thr Phe Gln Leu
                1445                1450                1455    
Asp Cys Asp Ala Val Leu Gln Leu Phe Ile Glu Thr Leu Leu His Asn
            1460                1465                1470        
Thr Asn Ala Gly Gln Gly Gln Gly Asp Ala Ser Met Asp Ser Ala Lys
        1475                1480                1485            
Arg Arg His Pro Lys Leu Leu Ala Lys Ala Leu Glu Met Val Pro Leu
    1490                1495                1500                
Leu Thr Ser Thr Lys Asp Leu Val Ile Ser Leu Ser Gly Ile Leu His
1505                1510                1515                1520
Lys Leu Asp Pro Tyr Asp Tyr Glu Met Ile Glu Val Val Leu Lys Val
                1525                1530                1535    
Ile Glu Arg Ala Asp Glu Lys Ile Thr Asn Ile Asn Ile Asn Gln Ala
            1540                1545                1550        
Leu Ser Ile Leu Lys His Leu Lys Ser Tyr Arg Arg Ile Ser Pro Pro
        1555                1560                1565            
Val Asp Leu Glu Tyr Gln Tyr Met Leu Glu His Val Ile Thr Leu Pro
    1570                1575                1580                
Ser Ala Ala Gln Thr Arg Leu Pro Phe His Leu Ile Phe Phe Gly Thr
1585                1590                1595                1600
Ala Gln Asn Phe Trp Lys Ile Leu Ser Thr Glu Leu Ser Glu Glu Ser
                1605                1610                1615    
Phe Pro Thr Leu Leu Leu Ile Ser Lys Leu Met Lys Phe Ser Leu Asp
            1620                1625                1630        
Thr Leu Tyr Val Ser Thr Ala Lys His Val Phe Glu Lys Lys Leu Lys
        1635                1640                1645            
Pro Lys Leu Leu Lys Leu Thr Gln Ala Lys Ser Ser Thr Leu Ile Asn
    1650                1655                1660                
Lys Glu Ile Thr Lys Ile Thr Gln Thr Ile Glu Ser Cys Leu Leu Ser
1665                1670                1675                1680
Ile Val Asn Pro Glu Trp Ala Val Ala Ile Ala Ile Ser Leu Ala Gln
                1685                1690                1695    
Asp Ile Pro Glu Gly Ser Phe Lys Ile Ser Ala Leu Lys Phe Cys Leu
            1700                1705                1710        
Tyr Leu Ala Glu Arg Trp Leu Gln Asn Ile Pro Ser Gln Asp Glu Lys
        1715                1720                1725            
Arg Glu Lys Ala Glu Ala Leu Leu Lys Lys Leu His Ile Gln Tyr Arg
    1730                1735                1740                
Arg Ser Gly Thr Glu Ala Val Leu Ile Ala His Lys Leu Asn Thr Glu
1745                1750                1755                1760
Glu Tyr Leu Arg Val Ile Gly Lys Pro Ala His Leu Ile Val Ser Leu
                1765                1770                1775    
Tyr Glu His Pro Ser Ile Asn Gln Arg Ile Gln Asn Ser Ser Gly Thr
            1780                1785                1790        
Asp Tyr Pro Asp Ile His Ala Ala Ala Lys Glu Ile Ala Glu Val Asn
        1795                1800                1805            
Glu Ile Asn Leu Glu Lys Val Trp Asp Met Leu Leu Glu Lys Trp Leu
    1810                1815                1820                
Cys Pro Ser Thr Lys Pro Gly Glu Lys Pro Ser Glu Leu Phe Glu Leu
1825                1830                1835                1840
Gln Glu Asp Glu Ala Leu Arg Arg Val Gln Tyr Leu Leu Leu Ser Arg
                1845                1850                1855    
Pro Ile Asp Tyr Ser Ser Arg Met Leu Phe Val Phe Ala Thr Ser Thr
            1860                1865                1870        
Thr Thr Thr Leu Gly Met His Gln Leu Thr Phe Ala His Arg Thr Arg
        1875                1880                1885            
Ala Leu Gln Cys Leu Phe Tyr Leu Ala Asp Lys Glu Thr Ile Glu Ser
    1890                1895                1900                
Leu Phe Lys Lys Pro Ile Glu Glu Val Lys Ser Tyr Leu Arg Cys Ile
1905                1910                1915                1920
Thr Phe Leu Ala Ser Phe Glu Thr Leu Asn Ile Pro Ile Thr Tyr Glu
                1925                1930                1935    
Leu Phe Cys Ser Ser Pro Lys Glu Gly Met Ile Lys Gly Leu Trp Lys
            1940                1945                1950        
Asn His Ser His Glu Ser Met Ala Val Arg Leu Val Thr Glu Leu Cys
        1955                1960                1965            
Leu Glu Tyr Lys Ile Tyr Asp Leu Gln Leu Trp Asn Gly Leu Leu Gln
    1970                1975                1980                
Lys Leu Leu Gly Phe Asn Met Ile Pro Tyr Leu Arg Lys Val Leu Lys
1985                1990                1995                2000
Ala Ile Ser Ser Ile His Ser Leu Trp Gln Val Pro Tyr Phe Ser Lys
                2005                2010                2015    
Ala Trp Gln Arg Val Ile Gln Ile Pro Leu Leu Ser Ala Ser Cys Pro
            2020                2025                2030        
Leu Ser Pro Asp Gln Leu Ser Asp Cys Ser Glu Ser Leu Ile Ala Val
        2035                2040                2045            
Leu Glu Cys Pro Val Ser Gly Asp Leu Asp Leu Ile Gly Val Ala Arg
    2050                2055                2060                
Gln Tyr Ile Gln Leu Glu Leu Pro Ala Phe Ala Leu Ala Cys Leu Met
2065                2070                2075                2080
Leu Met Pro His Ser Glu Lys Arg His Gln Gln Ile Lys Asn Phe Leu
                2085                2090                2095    
Gly Ser Cys Asp Pro Gln Val Ile Leu Lys Gln Leu Glu Glu His Met
            2100                2105                2110        
Asn Thr Gly Gln Leu Ala Gly Phe Ser His Gln Ile Arg Ser Leu Ile
        2115                2120                2125            
Leu Asn Asn Ile Ile Asn Lys Lys Glu Phe Gly Ile Leu Ala Lys Thr
    2130                2135                2140                
Lys Tyr Phe Gln Met Leu Lys Met His Ala Met Asn Thr Asn Asn Ile
2145                2150                2155                2160
Thr Glu Leu Val Asn Tyr Leu Ala Asn Asp Leu Ser Leu Asp Glu Ala
                2165                2170                2175    
Ser Val Leu Ile Thr Glu Tyr Ser Lys His Cys Gly Lys Pro Val Pro
            2180                2185                2190        
Pro Asp Thr Ala Pro Cys Glu Ile Leu Lys Met Phe Leu Ser Gly Leu
        2195                2200                2205            
Ser
    


<210> 8202
<211> 690
<212> PRT
<213> Homo sapiens

<400> 8202
Met Ser Ala Glu Asn Asn Gln Leu Ser Gly Ala Ser Pro Pro His Pro
 1               5                  10                  15      
Pro Thr Thr Pro Gln Tyr Ser Thr Gln Asn Leu Pro Ser Glu Lys Glu
            20                  25                  30          
Asp Thr Glu Val Glu Leu Asp Glu Glu Ser Leu Gln Asp Glu Ser Pro
        35                  40                  45              
Phe Ser Pro Glu Gly Glu Ser Leu Glu Asp Lys Glu Tyr Leu Glu Glu
    50                  55                  60                  
Glu Glu Asp Leu Glu Glu Glu Glu Tyr Leu Gly Lys Glu Glu Tyr Leu
65                  70                  75                  80  
Lys Glu Glu Glu Tyr Leu Gly Lys Glu Glu His Leu Glu Glu Glu Glu
                85                  90                  95      
Tyr Leu Glu Lys Val Gly Tyr Leu Glu Glu Glu Glu Tyr Ile Glu Glu
            100                 105                 110         
Glu Glu Tyr Leu Gly Lys Glu Gly Tyr Leu Glu Glu Glu Glu Tyr Leu
        115                 120                 125             
Gly Lys Glu Glu His Leu Gly Lys Glu Gly Tyr Leu Glu Lys Glu Asp
    130                 135                 140                 
Tyr Ile Glu Glu Val Asp Tyr Leu Gly Lys Lys Ala Tyr Leu Glu Glu
145                 150                 155                 160 
Glu Glu Tyr Leu Gly Lys Lys Ser Tyr Leu Glu Lys Glu Lys Ala Leu
                165                 170                 175     
Glu Lys Glu Glu Asn Leu Glu Glu Glu Glu Ala Leu Glu Lys Glu Glu
            180                 185                 190         
Asn Leu Asp Gly Lys Glu Asn Leu Tyr Lys Lys Tyr Leu Lys Glu Pro
        195                 200                 205             
Lys Ala Ser Tyr Ser Ser Gln Thr Met Leu Leu Arg Asp Ala Arg Ser
    210                 215                 220                 
Pro Asp Ala Gly Pro Ser Gln Val Thr Thr Phe Leu Thr Val Pro Leu
225                 230                 235                 240 
Thr Phe Ala Thr Pro Ser Pro Val Ser Glu Ser Ala Thr Glu Ser Ser
                245                 250                 255     
Glu Leu Leu Leu Thr Leu Tyr Arg Arg Ser Gln Ala Ser Gln Thr Asp
            260                 265                 270         
Trp Cys Tyr Asp Arg Thr Ala Val Lys Ser Leu Lys Ser Lys Ser Glu
        275                 280                 285             
Thr Glu Gln Glu Thr Thr Thr Lys Leu Ala Pro Glu Glu His Val Asn
    290                 295                 300                 
Thr Lys Val Gln Gln Lys Lys Glu Glu Asn Val Leu Glu Phe Ala Ser
305                 310                 315                 320 
Lys Glu Asn Phe Trp Asp Gly Ile Thr Asp Glu Ser Ile Asp Lys Leu
                325                 330                 335     
Glu Val Glu Asp Leu Asp Glu Asn Phe Leu Asn Ser Ser Tyr Gln Thr
            340                 345                 350         
Val Phe Lys Thr Ile Ile Lys Glu Met Ala Ala His Asn Glu Leu Glu
        355                 360                 365             
Glu Asp Phe Asp Ile Pro Leu Thr Lys Leu Leu Glu Ser Glu Asn Arg
    370                 375                 380                 
Trp Lys Leu Val Ile Met Leu Lys Lys Asn Tyr Glu Lys Phe Lys Glu
385                 390                 395                 400 
Thr Ile Leu Arg Ile Lys Arg Arg Arg Glu Ala Gln Lys Leu Thr Glu
                405                 410                 415     
Met Thr Ser Phe Thr Phe His Leu Met Ser Lys Pro Thr Pro Glu Lys
            420                 425                 430         
Pro Glu Thr Glu Glu Ile Gln Lys Pro Gln Arg Val Val His His Arg
        435                 440                 445             
Lys Lys Leu Glu Arg Asp Lys Glu Trp Ile Gln Lys Lys Thr Val Val
    450                 455                 460                 
His Gln Gly Asp Gly Lys Leu Ile Leu Tyr Pro Asn Lys Asn Val Tyr
465                 470                 475                 480 
Gln Ile Leu Phe Pro Asp Gly Thr Gly Gln Ile His Tyr Pro Ser Gly
                485                 490                 495     
Asn Leu Ala Met Leu Ile Leu Tyr Ala Lys Met Lys Lys Phe Thr Tyr
            500                 505                 510         
Ile Ile Leu Glu Asp Ser Leu Glu Gly Arg Ile Arg Ala Leu Ile Asn
        515                 520                 525             
Asn Ser Gly Asn Ala Thr Phe Tyr Asp Glu Asn Ser Asp Ile Trp Leu
    530                 535                 540                 
Asn Leu Ser Ser Asn Leu Gly Tyr Tyr Phe Pro Lys Asp Lys Arg Gln
545                 550                 555                 560 
Lys Ala Trp Asn Trp Trp Asn Leu Asn Ile His Val His Ala Pro Pro
                565                 570                 575     
Val Gln Pro Ile Ser Leu Lys Ile Asn Glu Tyr Ile Gln Val Gln Ile
            580                 585                 590         
Arg Ser Gln Asp Lys Ile Ile Phe Cys Phe Thr Tyr Glu Gln Lys Gln
        595                 600                 605             
Ile Cys Leu Asn Leu Gly Thr Arg Tyr Lys Phe Val Ile Pro Glu Val
    610                 615                 620                 
Leu Ser Glu Met Lys Lys Lys Thr Ile Leu Glu Ala Glu Pro Gly Pro
625                 630                 635                 640 
Thr Ala Gln Lys Ile Arg Val Leu Leu Gly Lys Met Asn Arg Leu Leu
                645                 650                 655     
Asn Tyr Ala Thr Thr Pro Asp Leu Glu Asn Phe Ile Glu Ala Val Ser
            660                 665                 670         
Ile Ser Leu Met Asp Asn Lys Tyr Leu Lys Lys Met Leu Ser Lys Leu
        675                 680                 685             
Trp Phe
    690 


<210> 8203
<211> 2136
<212> PRT
<213> Homo sapiens

<400> 8203
Met Ser Arg Ser Arg His Ala Arg Pro Ser Arg Leu Val Arg Lys Glu
 1               5                  10                  15      
Asp Val Asn Lys Lys Lys Lys Asn Ser Gln Leu Arg Lys Thr Thr Lys
            20                  25                  30          
Gly Ala Asn Lys Asn Val Ala Ser Val Lys Thr Leu Ser Pro Gly Lys
        35                  40                  45              
Leu Lys Gln Leu Ile Gln Glu Arg Asp Val Lys Lys Lys Thr Glu Pro
    50                  55                  60                  
Lys Pro Pro Val Pro Val Arg Ser Leu Leu Thr Arg Ala Gly Ala Ala
65                  70                  75                  80  
Arg Met Asn Leu Asp Arg Thr Glu Val Leu Phe Gln Asn Pro Glu Ser
                85                  90                  95      
Leu Thr Cys Asn Gly Phe Thr Met Ala Leu Arg Ser Thr Ser Leu Ser
            100                 105                 110         
Arg Arg Leu Ser Gln Pro Pro Leu Val Val Ala Lys Ser Lys Lys Val
        115                 120                 125             
Pro Leu Ser Lys Gly Leu Glu Lys Gln His Asp Cys Asp Tyr Lys Ile
    130                 135                 140                 
Leu Pro Ala Leu Gly Val Lys His Ser Glu Asn Asp Ser Val Pro Met
145                 150                 155                 160 
Gln Asp Thr Gln Val Leu Pro Asp Ile Glu Thr Leu Ile Gly Val Gln
                165                 170                 175     
Asn Pro Ser Leu Leu Lys Gly Lys Ser Gln Glu Thr Thr Gln Phe Trp
            180                 185                 190         
Ser Gln Arg Val Glu Asp Ser Lys Ile Asn Ile Pro Thr His Ser Gly
        195                 200                 205             
Pro Ala Ala Glu Ile Leu Pro Gly Pro Leu Glu Gly Thr Arg Cys Gly
    210                 215                 220                 
Glu Gly Leu Phe Ser Glu Glu Thr Leu Asn Asp Thr Ser Gly Ser Pro
225                 230                 235                 240 
Lys Met Phe Ala Gln Asp Thr Val Cys Ala Pro Phe Pro Gln Arg Ala
                245                 250                 255     
Thr Pro Lys Val Thr Ser Gln Gly Asn Pro Ser Ile Gln Leu Glu Glu
            260                 265                 270         
Leu Gly Ser Arg Val Glu Ser Leu Lys Leu Ser Asp Ser Tyr Leu Asp
        275                 280                 285             
Pro Ile Lys Ser Glu His Asp Cys Tyr Pro Thr Ser Ser Leu Asn Lys
    290                 295                 300                 
Val Ile Pro Asp Leu Asn Leu Arg Asn Cys Leu Ala Leu Gly Gly Ser
305                 310                 315                 320 
Thr Ser Pro Thr Ser Val Ile Lys Phe Leu Leu Ala Gly Ser Lys Gln
                325                 330                 335     
Ala Thr Leu Gly Ala Lys Pro Asp His Gln Glu Ala Phe Glu Ala Thr
            340                 345                 350         
Ala Asn Gln Gln Glu Val Ser Asp Thr Thr Ser Phe Leu Gly Gln Ala
        355                 360                 365             
Phe Gly Ala Ile Pro His Gln Trp Glu Leu Pro Gly Ala Asp Pro Val
    370                 375                 380                 
His Gly Glu Ala Leu Gly Glu Thr Pro Asp Leu Pro Glu Ile Pro Gly
385                 390                 395                 400 
Ala Ile Pro Val Gln Gly Glu Val Phe Gly Thr Ile Leu Asp Gln Gln
                405                 410                 415     
Glu Thr Leu Gly Met Ser Gly Ser Val Val Pro Asp Leu Pro Val Phe
            420                 425                 430         
Leu Pro Val Pro Pro Asn Pro Ile Ala Thr Phe Asn Ala Pro Ser Lys
        435                 440                 445             
Trp Pro Glu Pro Gln Ser Thr Val Ser Tyr Gly Leu Ala Val Gln Gly
    450                 455                 460                 
Ala Ile Gln Ile Leu Pro Leu Gly Ser Gly His Thr Pro Gln Ser Ser
465                 470                 475                 480 
Ser Asn Ser Glu Lys Asn Ser Leu Pro Pro Val Met Ala Ile Ser Asn
                485                 490                 495     
Val Glu Asn Glu Lys Gln Val His Ile Ser Phe Leu Pro Ala Asn Thr
            500                 505                 510         
Gln Gly Phe Pro Leu Ala Pro Glu Arg Gly Leu Phe His Ala Ser Leu
        515                 520                 525             
Gly Ile Ala Gln Leu Ser Gln Ala Gly Pro Ser Lys Ser Asp Arg Gly
    530                 535                 540                 
Ser Ser Gln Val Ser Val Thr Ser Thr Val His Val Val Asn Thr Thr
545                 550                 555                 560 
Val Val Thr Met Pro Val Pro Met Val Ser Thr Ser Ser Ser Ser Tyr
                565                 570                 575     
Thr Thr Leu Leu Pro Thr Leu Glu Lys Lys Lys Arg Lys Arg Cys Gly
            580                 585                 590         
Val Cys Glu Pro Cys Gln Gln Lys Thr Asn Cys Gly Glu Cys Thr Tyr
        595                 600                 605             
Cys Lys Asn Arg Lys Asn Ser His Gln Ile Cys Lys Lys Arg Lys Cys
    610                 615                 620                 
Glu Glu Leu Lys Lys Lys Pro Ser Val Val Val Pro Leu Glu Val Ile
625                 630                 635                 640 
Lys Glu Asn Lys Arg Pro Gln Arg Glu Lys Lys Pro Lys Val Leu Lys
                645                 650                 655     
Ala Asp Phe Asp Asn Lys Pro Val Asn Gly Pro Lys Ser Glu Ser Met
            660                 665                 670         
Asp Tyr Ser Arg Cys Gly His Gly Glu Glu Gln Lys Leu Glu Leu Asn
        675                 680                 685             
Pro His Thr Val Glu Asn Val Thr Lys Asn Glu Asp Ser Met Thr Gly
    690                 695                 700                 
Ile Glu Val Glu Lys Trp Thr Gln Asn Lys Lys Ser Gln Leu Thr Asp
705                 710                 715                 720 
His Val Lys Gly Asp Phe Ser Ala Asn Val Pro Glu Ala Glu Lys Ser
                725                 730                 735     
Lys Asn Ser Glu Val Asp Lys Lys Arg Thr Lys Ser Pro Lys Leu Phe
            740                 745                 750         
Val Gln Thr Val Arg Asn Gly Ile Lys His Val His Cys Leu Pro Ala
        755                 760                 765             
Glu Thr Asn Val Ser Phe Lys Lys Phe Asn Ile Glu Glu Phe Gly Lys
    770                 775                 780                 
Thr Leu Glu Asn Asn Ser Tyr Lys Phe Leu Lys Asp Thr Ala Asn His
785                 790                 795                 800 
Lys Asn Ala Met Ser Ser Val Ala Thr Asp Met Ser Cys Asp His Leu
                805                 810                 815     
Lys Gly Arg Ser Asn Val Leu Val Phe Gln Gln Pro Gly Phe Asn Cys
            820                 825                 830         
Ser Ser Ile Pro His Ser Ser His Ser Ile Ile Asn His His Ala Ser
        835                 840                 845             
Ile His Asn Glu Gly Asp Gln Pro Lys Thr Pro Glu Asn Ile Pro Ser
    850                 855                 860                 
Lys Glu Pro Lys Asp Gly Ser Pro Val Gln Pro Ser Leu Leu Ser Leu
865                 870                 875                 880 
Met Lys Asp Arg Arg Leu Thr Leu Glu Gln Val Val Ala Ile Glu Ala
                885                 890                 895     
Leu Thr Gln Leu Ser Glu Ala Pro Ser Glu Asn Ser Ser Pro Ser Lys
            900                 905                 910         
Ser Glu Lys Asp Glu Glu Ser Glu Gln Arg Thr Ala Ser Leu Leu Asn
        915                 920                 925             
Ser Cys Lys Ala Ile Leu Tyr Thr Val Arg Lys Asp Leu Gln Asp Pro
    930                 935                 940                 
Asn Leu Gln Gly Glu Pro Pro Lys Leu Asn His Cys Pro Ser Leu Glu
945                 950                 955                 960 
Lys Gln Ser Ser Cys Asn Thr Val Val Phe Asn Gly Gln Thr Thr Thr
                965                 970                 975     
Leu Ser Asn Ser His Ile Asn Ser Ala Thr Asn Gln Ala Ser Thr Lys
            980                 985                 990         
Ser His Glu Tyr Ser Lys Val Thr Asn Ser Leu Ser Leu Phe Ile Pro
        995                 1000                1005            
Lys Ser Asn Ser Ser Lys Ile Asp Thr Asn Lys Ser Ile Ala Gln Gly
    1010                1015                1020                
Ile Ile Thr Leu Asp Asn Cys Ser Asn Asp Leu His Gln Leu Pro Pro
1025                1030                1035                1040
Arg Asn Asn Glu Val Glu Tyr Cys Asn Gln Leu Leu Asp Ser Ser Lys
                1045                1050                1055    
Lys Leu Asp Ser Asp Asp Leu Ser Cys Gln Asp Ala Thr His Thr Gln
            1060                1065                1070        
Ile Glu Glu Asp Val Ala Thr Gln Leu Thr Gln Leu Ala Ser Ile Ile
        1075                1080                1085            
Lys Ile Asn Tyr Ile Lys Pro Glu Asp Lys Lys Val Glu Ser Thr Pro
    1090                1095                1100                
Thr Ser Leu Val Thr Cys Asn Val Gln Gln Lys Tyr Asn Gln Glu Lys
1105                1110                1115                1120
Gly Thr Met Gln Gln Lys Pro Pro Ser Ser Val His Asn Asn His Gly
                1125                1130                1135    
Ser Ser Leu Thr Lys Gln Lys Asn Pro Thr Gln Lys Lys Thr Lys Ser
            1140                1145                1150        
Thr Pro Ser Arg Asp Arg Arg Lys Lys Lys Pro Thr Val Val Ser Tyr
        1155                1160                1165            
Gln Glu Asn Asp Arg Gln Lys Trp Glu Lys Leu Ser Tyr Met Tyr Gly
    1170                1175                1180                
Thr Ile Cys Asp Ile Trp Ile Ala Ser Lys Phe Gln Asn Phe Gly Gln
1185                1190                1195                1200
Phe Cys Pro His Asp Phe Pro Thr Val Phe Gly Lys Ile Ser Ser Ser
                1205                1210                1215    
Thr Lys Ile Trp Lys Pro Leu Ala Gln Thr Arg Ser Ile Met Gln Pro
            1220                1225                1230        
Lys Thr Val Phe Pro Pro Leu Thr Gln Ile Lys Leu Gln Arg Tyr Pro
        1235                1240                1245            
Glu Ser Ala Glu Glu Lys Val Lys Val Glu Pro Leu Asp Ser Leu Ser
    1250                1255                1260                
Leu Phe His Leu Lys Thr Glu Ser Asn Gly Lys Ala Phe Thr Asp Lys
1265                1270                1275                1280
Ala Tyr Asn Ser Gln Val Gln Leu Thr Val Asn Ala Asn Gln Lys Ala
                1285                1290                1295    
His Pro Leu Thr Gln Pro Ser Ser Pro Pro Asn Gln Cys Ala Asn Val
            1300                1305                1310        
Met Ala Gly Asp Asp Gln Ile Arg Phe Gln Gln Val Val Lys Glu Gln
        1315                1320                1325            
Leu Met His Gln Arg Leu Pro Thr Leu Pro Gly Ile Ser His Glu Thr
    1330                1335                1340                
Pro Leu Pro Glu Ser Ala Leu Thr Leu Arg Asn Val Asn Val Val Cys
1345                1350                1355                1360
Ser Gly Gly Ile Thr Val Val Ser Thr Lys Ser Glu Glu Glu Val Cys
                1365                1370                1375    
Ser Ser Ser Phe Gly Thr Ser Glu Phe Ser Thr Val Asp Ser Ala Gln
            1380                1385                1390        
Lys Asn Phe Asn Asp Tyr Ala Met Asn Phe Phe Thr Asn Pro Thr Lys
        1395                1400                1405            
Asn Leu Val Ser Ile Thr Lys Asp Ser Glu Leu Pro Thr Cys Ser Cys
    1410                1415                1420                
Leu Asp Arg Val Ile Gln Lys Asp Lys Gly Pro Tyr Tyr Thr His Leu
1425                1430                1435                1440
Gly Ala Gly Pro Ser Val Ala Ala Val Arg Glu Ile Met Glu Asn Arg
                1445                1450                1455    
Tyr Gly Gln Lys Gly Asn Ala Ile Arg Ile Glu Ile Val Val Tyr Thr
            1460                1465                1470        
Gly Lys Glu Gly Lys Ser Ser His Gly Cys Pro Ile Ala Lys Trp Val
        1475                1480                1485            
Leu Arg Arg Ser Ser Asp Glu Glu Lys Val Leu Cys Leu Val Arg Gln
    1490                1495                1500                
Arg Thr Gly His His Cys Pro Thr Ala Val Met Val Val Leu Ile Met
1505                1510                1515                1520
Val Trp Asp Gly Ile Pro Leu Pro Met Ala Asp Arg Leu Tyr Thr Glu
                1525                1530                1535    
Leu Thr Glu Asn Leu Lys Ser Tyr Asn Gly His Pro Thr Asp Arg Arg
            1540                1545                1550        
Cys Thr Leu Asn Glu Asn Arg Thr Cys Thr Cys Gln Gly Ile Asp Pro
        1555                1560                1565            
Glu Thr Cys Gly Ala Ser Phe Ser Phe Gly Cys Ser Trp Ser Met Tyr
    1570                1575                1580                
Phe Asn Gly Cys Lys Phe Gly Arg Ser Pro Ser Pro Arg Arg Phe Arg
1585                1590                1595                1600
Ile Asp Pro Ser Ser Pro Leu His Glu Lys Asn Leu Glu Asp Asn Leu
                1605                1610                1615    
Gln Ser Leu Ala Thr Arg Leu Ala Pro Ile Tyr Lys Gln Tyr Ala Pro
            1620                1625                1630        
Val Ala Tyr Gln Asn Gln Val Glu Tyr Glu Asn Val Ala Arg Glu Cys
        1635                1640                1645            
Arg Leu Gly Ser Lys Glu Gly Arg Pro Phe Ser Gly Val Thr Ala Cys
    1650                1655                1660                
Leu Asp Phe Cys Ala His Pro His Arg Asp Ile His Asn Met Asn Asn
1665                1670                1675                1680
Gly Ser Thr Val Val Cys Thr Leu Thr Arg Glu Asp Asn Arg Ser Leu
                1685                1690                1695    
Gly Val Ile Pro Gln Asp Glu Gln Leu His Val Leu Pro Leu Tyr Lys
            1700                1705                1710        
Leu Ser Asp Thr Asp Glu Phe Gly Ser Lys Glu Gly Met Glu Ala Lys
        1715                1720                1725            
Ile Lys Ser Gly Ala Ile Glu Val Leu Ala Pro Arg Arg Lys Lys Arg
    1730                1735                1740                
Thr Cys Phe Thr Gln Pro Val Pro Arg Ser Gly Lys Lys Arg Ala Ala
1745                1750                1755                1760
Met Met Thr Glu Val Leu Ala His Lys Ile Arg Ala Val Glu Lys Lys
                1765                1770                1775    
Pro Ile Pro Arg Ile Lys Arg Lys Asn Asn Ser Thr Thr Thr Asn Asn
            1780                1785                1790        
Ser Lys Pro Ser Ser Leu Pro Thr Leu Gly Ser Asn Thr Glu Thr Val
        1795                1800                1805            
Gln Pro Glu Val Lys Ser Glu Thr Glu Pro His Phe Ile Leu Lys Ser
    1810                1815                1820                
Ser Asp Asn Thr Lys Thr Tyr Ser Leu Met Pro Ser Ala Pro His Pro
1825                1830                1835                1840
Val Lys Glu Ala Ser Pro Gly Phe Ser Trp Ser Pro Lys Thr Ala Ser
                1845                1850                1855    
Ala Thr Pro Ala Pro Leu Lys Asn Asp Ala Thr Ala Ser Cys Gly Phe
            1860                1865                1870        
Ser Glu Arg Ser Ser Thr Pro His Cys Thr Met Pro Ser Gly Arg Leu
        1875                1880                1885            
Ser Gly Ala Asn Ala Ala Ala Ala Asp Gly Pro Gly Ile Ser Gln Leu
    1890                1895                1900                
Gly Glu Val Ala Pro Leu Pro Thr Leu Ser Ala Pro Val Met Glu Pro
1905                1910                1915                1920
Leu Ile Asn Ser Glu Pro Ser Thr Gly Val Thr Glu Pro Leu Thr Pro
                1925                1930                1935    
His Gln Pro Asn His Gln Pro Ser Phe Leu Thr Ser Pro Gln Asp Leu
            1940                1945                1950        
Ala Ser Ser Pro Met Glu Glu Asp Glu Gln His Ser Glu Ala Asp Glu
        1955                1960                1965            
Pro Pro Ser Asp Glu Pro Leu Ser Asp Asp Pro Leu Ser Pro Ala Glu
    1970                1975                1980                
Glu Lys Leu Pro His Ile Asp Glu Tyr Trp Ser Asp Ser Glu His Ile
1985                1990                1995                2000
Phe Leu Asp Ala Asn Ile Gly Gly Val Ala Ile Ala Pro Ala His Gly
                2005                2010                2015    
Ser Val Leu Ile Glu Cys Ala Arg Arg Glu Leu His Ala Thr Thr Pro
            2020                2025                2030        
Val Glu His Pro Asn Arg Asn His Pro Thr Arg Leu Ser Leu Val Phe
        2035                2040                2045            
Tyr Gln His Lys Asn Leu Asn Lys Pro Gln His Gly Phe Glu Leu Asn
    2050                2055                2060                
Lys Ile Lys Phe Glu Ala Lys Glu Ala Lys Asn Lys Lys Met Lys Ala
2065                2070                2075                2080
Ser Glu Gln Lys Asp Gln Ala Ala Asn Glu Gly Pro Glu Gln Ser Ser
                2085                2090                2095    
Glu Val Asn Glu Leu Asn Gln Ile Pro Ser His Lys Ala Leu Thr Leu
            2100                2105                2110        
Thr His Asp Asn Val Val Thr Val Ser Pro Tyr Ala Leu Thr His Val
        2115                2120                2125            
Ala Gly Pro Tyr Asn His Trp Val
    2130                2135    


<210> 8204
<211> 1537
<212> PRT
<213> Homo sapiens

<400> 8204
Met Thr Thr Lys Arg Lys Ile Ile Gly Arg Leu Val Pro Cys Arg Cys
 1               5                  10                  15      
Phe Arg Gly Glu Glu Glu Ile Ile Ser Val Leu Asp Tyr Ser His Cys
            20                  25                  30          
Ser Leu Gln Gln Val Pro Lys Glu Val Phe Asn Phe Glu Arg Thr Leu
        35                  40                  45              
Glu Glu Leu Tyr Leu Asp Ala Asn Gln Ile Glu Glu Leu Pro Lys Gln
    50                  55                  60                  
Leu Phe Asn Cys Gln Ala Leu Arg Lys Leu Ser Ile Pro Asp Asn Asp
65                  70                  75                  80  
Leu Ser Asn Leu Pro Thr Thr Ile Ala Ser Leu Val Asn Leu Lys Glu
                85                  90                  95      
Leu Asp Ile Ser Lys Asn Gly Val Gln Glu Phe Pro Glu Asn Ile Lys
            100                 105                 110         
Cys Cys Lys Cys Leu Thr Ile Ile Glu Ala Ser Val Asn Pro Ile Ser
        115                 120                 125             
Lys Leu Pro Asp Gly Phe Thr Gln Leu Leu Asn Leu Thr Gln Leu Tyr
    130                 135                 140                 
Leu Asn Asp Ala Phe Leu Glu Phe Leu Pro Ala Asn Phe Gly Arg Leu
145                 150                 155                 160 
Val Lys Leu Arg Ile Leu Glu Leu Arg Glu Asn His Leu Lys Thr Leu
                165                 170                 175     
Pro Lys Ser Met His Lys Leu Ala Gln Leu Glu Arg Leu Asp Leu Gly
            180                 185                 190         
Asn Asn Glu Phe Gly Glu Leu Pro Glu Val Leu Asp Gln Ile Gln Asn
        195                 200                 205             
Leu Arg Glu Leu Trp Met Asp Asn Asn Ala Leu Gln Val Leu Pro Gly
    210                 215                 220                 
Ser Ile Gly Lys Leu Lys Met Leu Val Tyr Leu Asp Met Ser Lys Asn
225                 230                 235                 240 
Arg Ile Glu Thr Val Asp Met Asp Ile Ser Gly Cys Glu Ala Leu Glu
                245                 250                 255     
Asp Leu Leu Leu Ser Ser Asn Met Leu Gln Gln Leu Pro Asp Ser Ile
            260                 265                 270         
Gly Leu Leu Lys Lys Leu Thr Thr Leu Lys Val Asp Asp Asn Gln Leu
        275                 280                 285             
Thr Met Leu Pro Asn Thr Ile Gly Asn Leu Ser Leu Leu Glu Glu Phe
    290                 295                 300                 
Asp Cys Ser Cys Asn Glu Leu Glu Ser Leu Pro Ser Thr Ile Gly Tyr
305                 310                 315                 320 
Leu His Ser Leu Arg Thr Leu Ala Val Asp Glu Asn Phe Leu Pro Glu
                325                 330                 335     
Leu Pro Arg Glu Ile Gly Ser Cys Lys Asn Val Thr Val Met Ser Leu
            340                 345                 350         
Arg Ser Asn Lys Leu Glu Phe Leu Pro Glu Glu Ile Gly Gln Met Gln
        355                 360                 365             
Lys Leu Arg Val Leu Asn Leu Ser Asp Asn Arg Leu Lys Asn Leu Pro
    370                 375                 380                 
Phe Ser Phe Thr Lys Leu Lys Glu Leu Ala Ala Leu Trp Leu Ser Asp
385                 390                 395                 400 
Asn Gln Ser Lys Ala Leu Ile Pro Leu Gln Thr Glu Ala His Pro Glu
                405                 410                 415     
Thr Lys Gln Arg Val Leu Thr Asn Tyr Met Phe Pro Gln Gln Pro Arg
            420                 425                 430         
Gly Asp Glu Asp Phe Gln Ser Asp Ser Asp Ser Phe Asn Pro Thr Leu
        435                 440                 445             
Trp Glu Glu Gln Arg Gln Gln Arg Met Thr Val Ala Phe Glu Phe Glu
    450                 455                 460                 
Asp Lys Lys Glu Asp Asp Glu Asn Ala Gly Lys Val Lys Asp Leu Ser
465                 470                 475                 480 
Cys Gln Ala Pro Trp Glu Arg Gly Gln Arg Gly Ile Thr Leu Gln Pro
                485                 490                 495     
Ala Arg Leu Ser Gly Asp Cys Cys Thr Pro Trp Ala Arg Cys Asp Gln
            500                 505                 510         
Gln Ile Gln Asp Met Pro Val Pro Gln Asn Asp Pro Gln Leu Ala Trp
        515                 520                 525             
Gly Cys Ile Ser Gly Leu Gln Gln Glu Arg Ser Met Cys Thr Pro Leu
    530                 535                 540                 
Pro Val Ala Ala Gln Ser Thr Thr Leu Pro Ser Leu Ser Gly Arg Gln
545                 550                 555                 560 
Val Glu Ile Asn Leu Lys Arg Tyr Pro Thr Pro Tyr Pro Glu Asp Leu
                565                 570                 575     
Lys Asn Met Val Lys Ser Val Gln Asn Leu Val Gly Lys Pro Ser His
            580                 585                 590         
Gly Val Arg Val Glu Asn Ser Asn Pro Thr Ala Asn Thr Glu Gln Thr
        595                 600                 605             
Val Lys Glu Lys Tyr Glu His Lys Trp Pro Val Ala Pro Lys Glu Ile
    610                 615                 620                 
Thr Val Glu Asp Ser Phe Val His Pro Ala Asn Glu Met Arg Ile Gly
625                 630                 635                 640 
Glu Leu His Pro Ser Leu Ala Glu Thr Pro Leu Tyr Pro Pro Lys Leu
                645                 650                 655     
Val Leu Leu Gly Lys Asp Lys Lys Glu Ser Thr Asp Glu Ser Glu Val
            660                 665                 670         
Asp Lys Thr His Cys Leu Asn Asn Ser Val Ser Ser Gly Thr Tyr Ser
        675                 680                 685             
Asp Tyr Ser Pro Ser Gln Ala Ser Ser Gly Ser Ser Asn Thr Arg Val
    690                 695                 700                 
Lys Val Gly Ser Leu Gln Thr Thr Ala Lys Asp Ala Val His Asn Ser
705                 710                 715                 720 
Leu Trp Gly Asn Arg Ile Ala Pro Ser Phe Pro Gln Pro Leu Asp Ser
                725                 730                 735     
Lys Pro Leu Leu Ser Gln Arg Glu Ala Val Pro Pro Gly Asn Ile Pro
            740                 745                 750         
Gln Arg Pro Asp Arg Leu Pro Met Ser Asp Thr Phe Thr Asp Asn Trp
        755                 760                 765             
Thr Asp Gly Ser His Tyr Asp Asn Thr Gly Phe Val Ala Glu Glu Thr
    770                 775                 780                 
Thr Ala Glu Asn Ala Asn Ser Asn Pro Leu Leu Ser Ser Lys Ser Arg
785                 790                 795                 800 
Ser Thr Ser Ser His Gly Arg Arg Pro Leu Ile Arg Gln Asp Arg Ile
                805                 810                 815     
Val Gly Val Pro Leu Glu Leu Glu Gln Ser Thr His Arg His Thr Pro
            820                 825                 830         
Glu Thr Glu Val Pro Pro Ser Asn Pro Trp Gln Asn Trp Thr Arg Thr
        835                 840                 845             
Pro Ser Pro Phe Glu Asp Arg Thr Ala Phe Pro Ser Lys Leu Glu Thr
    850                 855                 860                 
Thr Pro Thr Thr Ser Pro Leu Pro Glu Arg Lys Glu His Ile Lys Glu
865                 870                 875                 880 
Ser Thr Glu Ile Pro Ser Pro Phe Ser Pro Gly Val Pro Trp Glu Tyr
                885                 890                 895     
His Asp Ser Asn Pro Asn Arg Ser Leu Ser Asn Val Phe Ser Gln Ile
            900                 905                 910         
His Cys Arg Pro Glu Ser Ser Lys Gly Val Ile Ser Ile Ser Lys Ser
        915                 920                 925             
Thr Glu Arg Leu Ser Pro Leu Met Lys Asp Ile Lys Ser Asn Lys Phe
    930                 935                 940                 
Lys Lys Ser Gln Ser Ile Asp Glu Ile Asp Ile Gly Thr Tyr Lys Val
945                 950                 955                 960 
Tyr Asn Ile Pro Leu Glu Asn Tyr Ala Ser Gly Ser Asp His Leu Gly
                965                 970                 975     
Ser His Glu Arg Pro Asp Lys Met Leu Gly Pro Glu His Gly Met Ser
            980                 985                 990         
Ser Met Ser Arg Ser Gln Ser Val Pro Met Leu Asp Asp Glu Met Leu
        995                 1000                1005            
Thr Tyr Gly Ser Ser Lys Gly Pro Gln Gln Gln Lys Ala Ser Met Thr
    1010                1015                1020                
Lys Lys Val Tyr Gln Phe Asp Gln Ser Phe Asn Pro Gln Gly Ser Val
1025                1030                1035                1040
Glu Val Lys Ala Glu Lys Arg Ile Pro Pro Pro Phe Gln His Asn Pro
                1045                1050                1055    
Glu Tyr Val Gln Gln Ala Ser Lys Asn Ile Ala Lys Asp Leu Ile Ser
            1060                1065                1070        
Pro Arg Ala Tyr Arg Gly Tyr Pro Pro Met Glu Gln Met Phe Ser Phe
        1075                1080                1085            
Ser Gln Pro Ser Val Asn Glu Asp Ala Val Val Asn Ala Gln Phe Ala
    1090                1095                1100                
Ser Gln Gly Ala Arg Ala Gly Phe Leu Arg Arg Ala Asp Ser Leu Val
1105                1110                1115                1120
Ser Ala Thr Glu Met Ala Met Phe Arg Arg Val Asn Glu Pro His Glu
                1125                1130                1135    
Leu Pro Pro Thr Asp Arg Tyr Gly Arg Pro Pro Tyr Arg Gly Gly Leu
            1140                1145                1150        
Asp Arg Gln Ser Ser Val Thr Val Thr Glu Ser Gln Phe Leu Lys Arg
        1155                1160                1165            
Asn Gly Arg Tyr Glu Asp Glu His Pro Ser Tyr Gln Glu Val Lys Ala
    1170                1175                1180                
Gln Ala Gly Ser Phe Pro Val Lys Asn Leu Thr Gln Arg Arg Pro Leu
1185                1190                1195                1200
Ser Ala Arg Ser Tyr Ser Thr Glu Ser Tyr Gly Ala Ser Gln Thr Arg
                1205                1210                1215    
Pro Val Ser Ala Arg Pro Thr Met Ala Ala Leu Leu Glu Lys Ile Pro
            1220                1225                1230        
Ser Asp Tyr Asn Leu Gly Asn Tyr Gly Asp Lys Pro Ser Asp Asn Ser
        1235                1240                1245            
Asp Leu Lys Thr Arg Pro Thr Pro Val Lys Gly Glu Glu Ser Cys Gly
    1250                1255                1260                
Lys Met Pro Ala Asp Trp Arg Gln Gln Leu Leu Arg His Ile Glu Ala
1265                1270                1275                1280
Arg Arg Leu Asp Arg Asn Ala Ala Tyr Lys His Asn Thr Val Asn Leu
                1285                1290                1295    
Gly Met Leu Pro Tyr Gly Gly Ile Ser Ala Met His Ala Gly Arg Ser
            1300                1305                1310        
Met Thr Leu Asn Leu Gln Thr Lys Ser Lys Phe Asp His Gln Glu Leu
        1315                1320                1325            
Pro Leu Gln Lys Thr Pro Ser Gln Gln Ser Asn Ile Leu Asp Asn Gly
    1330                1335                1340                
Gln Glu Asp Val Ser Pro Ser Gly Gln Trp Asn Pro Tyr Pro Leu Gly
1345                1350                1355                1360
Arg Arg Asp Val Pro Pro Asp Thr Ile Thr Lys Lys Ala Gly Ser His
                1365                1370                1375    
Ile Gln Thr Leu Met Gly Ser Gln Ser Leu Gln His Arg Ser Arg Glu
            1380                1385                1390        
Gln Gln Pro Tyr Glu Gly Asn Ile Asn Lys Val Thr Ile Gln Gln Phe
        1395                1400                1405            
Gln Ser Pro Leu Pro Ile Gln Ile Pro Ser Ser Gln Ala Thr Arg Gly
    1410                1415                1420                
Pro Gln Pro Gly Arg Cys Leu Ile Gln Thr Lys Gly Gln Arg Ser Met
1425                1430                1435                1440
Asp Gly Tyr Pro Glu Gln Phe Cys Val Arg Ile Glu Lys Asn Pro Gly
                1445                1450                1455    
Leu Gly Phe Ser Ile Ser Gly Gly Ile Ser Gly Gln Gly Asn Pro Phe
            1460                1465                1470        
Lys Pro Ser Asp Lys Gly Ile Phe Val Thr Arg Val Gln Pro Asp Gly
        1475                1480                1485            
Pro Ala Ser Asn Leu Leu Gln Pro Gly Asp Lys Ile Leu Gln Ala Asn
    1490                1495                1500                
Gly His Ser Phe Val His Met Glu His Glu Lys Ala Val Leu Leu Leu
1505                1510                1515                1520
Lys Ser Phe Gln Asn Thr Val Asp Leu Val Ile Gln Arg Glu Leu Thr
                1525                1530                1535    
Val
    


<210> 8205
<211> 187
<212> PRT
<213> Homo sapiens

<400> 8205
Met Gln Phe Asp Asp Leu Thr Ala Glu Lys Glu Ala Val Ser Ser Lys
 1               5                  10                  15      
Cys Val Asp Leu Ala Lys Asp Asn Gln Val Leu Gln Gln Glu Leu Leu
            20                  25                  30          
Ser Met Lys Lys Val Gln Tyr Glu Lys Gln Leu Glu Gln Leu Asn Lys
        35                  40                  45              
Gly Asn Thr Ala Ser Leu Asn Lys Lys Glu Leu Thr Leu Lys Asp Val
    50                  55                  60                  
Glu Cys Lys Phe Ser Lys Met Lys Thr Thr Tyr Glu Glu Val Thr Thr
65                  70                  75                  80  
Lys Leu Glu Glu Tyr Lys Glu Ala Phe Ala Val Ala Leu Lys Ala Asn
                85                  90                  95      
Asn Ser Met Ser Lys Lys Leu Thr Lys Ser Asn Lys Lys Ile Ala Met
            100                 105                 110         
Ile Ser Thr Lys Leu Leu Met Glu Lys Glu Arg Val Lys Tyr Phe Leu
        115                 120                 125             
Ser Thr Leu Pro Thr Arg Arg Gly Pro Glu Ser Pro Cys Val Glu Asn
    130                 135                 140                 
Leu Thr Ser Ile Gly Leu Asn Arg Lys Tyr Ile Pro Gln Met Pro Val
145                 150                 155                 160 
Arg Ile Pro Thr Ser Asn Pro Gln Thr Ser Asn Asn Cys Gln Asn Tyr
                165                 170                 175     
Leu Thr Glu Val Arg Tyr Met Thr Val Ser Leu
            180                 185         


<210> 8206
<211> 279
<212> PRT
<213> Homo sapiens

<400> 8206
Tyr Lys Lys Leu Leu Glu Met Thr Ile Asn Val Leu Ser Val Phe Gly
 1               5                  10                  15      
Asn Glu Asp Phe Asp Cys His Gly Asp Leu Lys Thr Asp Gln Leu Lys
            20                  25                  30          
Met Asn Ile Leu Ile Lys Lys Leu Lys His Lys Phe Asp Asp Leu Thr
        35                  40                  45              
Ala Glu Lys Glu Ala Val Ser Ser Lys Cys Val Asp Leu Ala Lys Asp
    50                  55                  60                  
Asn Gln Val Leu Gln Gln Glu Leu Leu Ser Met Lys Lys Val Gln Gln
65                  70                  75                  80  
Gln Cys Glu Lys Leu Glu Lys Asp Lys Lys Met Leu Glu Glu Glu Ile
                85                  90                  95      
Leu Asn Leu Lys Thr His Met Glu Asp Asn Met Val Glu Leu Ser Lys
            100                 105                 110         
Leu Gln Glu Tyr Lys Ser Glu Leu Asp Glu Arg Ala Met Thr Ala Val
        115                 120                 125             
Glu Lys Leu Glu Glu Ile His Leu Gln Val Ser Phe Leu Asn Gln Leu
    130                 135                 140                 
Asn Lys Gly Asn Thr Ala Ser Leu Asn Lys Lys Glu Leu Thr Leu Lys
145                 150                 155                 160 
Asp Val Glu Cys Lys Phe Ser Lys Met Lys Thr Thr Tyr Glu Glu Val
                165                 170                 175     
Thr Thr Lys Leu Glu Glu Tyr Lys Glu Ala Phe Ala Val Ala Leu Lys
            180                 185                 190         
Ala Asn Asn Ser Met Ser Lys Lys Leu Thr Lys Ser Asn Lys Lys Ile
        195                 200                 205             
Ala Met Ile Ser Thr Lys Leu Leu Met Glu Lys Glu Arg Val Lys Tyr
    210                 215                 220                 
Phe Leu Ser Thr Leu Pro Thr Arg Arg Gly Pro Glu Ser Pro Cys Val
225                 230                 235                 240 
Glu Asn Leu Thr Ser Ile Gly Leu Asn Arg Lys Tyr Ile Pro Gln Met
                245                 250                 255     
Pro Val Arg Ile Pro Thr Ser Asn Pro Gln Thr Ser Asn Asn Cys Gln
            260                 265                 270         
Asn Tyr Leu Thr Glu Val Arg
        275                 


<210> 8207
<211> 434
<212> PRT
<213> Homo sapiens

<400> 8207
Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly
 1               5                  10                  15      
Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg
            20                  25                  30          
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45              
Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys
    50                  55                  60                  
Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser
65                  70                  75                  80  
Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu
                85                  90                  95      
Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110         
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu
        115                 120                 125             
Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile
    130                 135                 140                 
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160 
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu
                165                 170                 175     
Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu
            180                 185                 190         
Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205             
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu
    210                 215                 220                 
Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile
225                 230                 235                 240 
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys
                245                 250                 255     
Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr
            260                 265                 270         
Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro
        275                 280                 285             
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp
    290                 295                 300                 
Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu
305                 310                 315                 320 
Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala
                325                 330                 335     
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350         
Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met
        355                 360                 365             
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380                 
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400 
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu
                405                 410                 415     
Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser
            420                 425                 430         
Val Leu
        


<210> 8208
<211> 2325
<212> PRT
<213> Homo sapiens

<400> 8208
Met Lys Lys Gly Ser Gln Gln Lys Ile Phe Ser Lys Ala Lys Ile Pro
 1               5                  10                  15      
Ser Ser Ser His Ser Pro Ile Pro Ser Ser Met Ser Asn Met Arg Ser
            20                  25                  30          
Arg Ser Leu Ser Pro Leu Ile Gly Ser Glu Thr Leu Pro Phe His Ser
        35                  40                  45              
Gly Gly Gln Trp Cys Glu Gln Ile Glu Ile Ala Asp Glu Asn Asn Met
    50                  55                  60                  
Leu Leu Asp Tyr Gln Asp His Lys Gly Ala Asp Ser His Ala Gly Val
65                  70                  75                  80  
Arg Tyr Ile Thr Glu Ala Leu Ile Lys Lys Leu Thr Lys Gln Asp Asn
                85                  90                  95      
Leu Ala Leu Ile Lys Ser Leu Asn Leu Ser Leu Ser Lys Asp Gly Gly
            100                 105                 110         
Lys Lys Phe Lys Tyr Ile Glu Asn Leu Glu Lys Cys Val Lys Leu Glu
        115                 120                 125             
Val Leu Asn Leu Ser Tyr Asn Leu Ile Gly Lys Ile Glu Lys Leu Asp
    130                 135                 140                 
Lys Leu Leu Lys Leu Arg Glu Leu Asn Leu Ser Tyr Asn Lys Ile Ser
145                 150                 155                 160 
Lys Ile Glu Gly Ile Glu Asn Met Cys Asn Leu Gln Lys Leu Asn Leu
                165                 170                 175     
Ala Gly Asn Glu Ile Glu His Ile Pro Val Trp Leu Gly Lys Lys Leu
            180                 185                 190         
Lys Ser Leu Arg Val Leu Asn Leu Lys Gly Asn Lys Ile Ser Ser Leu
        195                 200                 205             
Gln Asp Ile Ser Lys Leu Lys Pro Leu Gln Asp Leu Ile Ser Leu Ile
    210                 215                 220                 
Leu Val Glu Asn Pro Val Val Thr Leu Pro His Tyr Leu Gln Phe Thr
225                 230                 235                 240 
Ile Phe His Leu Arg Ser Leu Glu Ser Leu Glu Gly Gln Pro Val Thr
                245                 250                 255     
Thr Gln Asp Arg Gln Glu Ala Phe Glu Arg Phe Ser Leu Glu Glu Val
            260                 265                 270         
Glu Arg Leu Glu Arg Asp Leu Glu Lys Lys Met Ile Glu Thr Glu Glu
        275                 280                 285             
Leu Lys Ser Lys Gln Thr Arg Phe Leu Glu Glu Ile Lys Asn Gln Asp
    290                 295                 300                 
Lys Leu Asn Lys Ser Leu Lys Glu Glu Ala Met Leu Gln Lys Gln Ser
305                 310                 315                 320 
Cys Glu Glu Leu Lys Ser Asp Leu Asn Thr Lys Asn Glu Leu Leu Lys
                325                 330                 335     
Gln Lys Thr Ile Glu Leu Thr Arg Ala Cys Gln Lys Gln Tyr Glu Leu
            340                 345                 350         
Glu Gln Glu Leu Ala Phe Tyr Lys Ile Asp Ala Lys Phe Glu Pro Leu
        355                 360                 365             
Asn Tyr Tyr Pro Ser Glu Tyr Ala Glu Ile Asp Lys Ala Pro Asp Glu
    370                 375                 380                 
Ser Pro Tyr Ile Gly Lys Ser Arg Tyr Lys Arg Asn Met Phe Ala Thr
385                 390                 395                 400 
Glu Ser Tyr Ile Ile Asp Ser Ala Gln Ala Val Gln Ile Lys Lys Met
                405                 410                 415     
Glu Pro Asp Glu Gln Leu Arg Asn Asp His Met Asn Leu Arg Gly His
            420                 425                 430         
Thr Pro Leu Asp Thr Gln Leu Glu Asp Lys Glu Lys Lys Ile Ser Ala
        435                 440                 445             
Ala Gln Thr Arg Leu Ser Glu Leu His Asp Glu Ile Glu Lys Ala Glu
    450                 455                 460                 
Gln Gln Ile Leu Arg Ala Thr Glu Glu Phe Lys Gln Leu Glu Glu Ala
465                 470                 475                 480 
Ile Gln Leu Lys Lys Ile Ser Glu Ala Gly Lys Asp Leu Leu Tyr Lys
                485                 490                 495     
Gln Leu Ser Gly Arg Leu Gln Leu Val Asn Lys Leu Arg Gln Glu Ala
            500                 505                 510         
Leu Asp Leu Glu Leu Gln Met Glu Lys Gln Lys Gln Glu Ile Ala Gly
        515                 520                 525             
Lys Gln Lys Glu Ile Lys Asp Leu Gln Ile Ala Ile Asp Ser Leu Asp
    530                 535                 540                 
Ser Lys Asp Pro Lys His Ser His Met Lys Ala Gln Lys Ser Gly Lys
545                 550                 555                 560 
Glu Gln Gln Leu Asp Ile Met Asn Lys Gln Tyr Gln Gln Leu Glu Ser
                565                 570                 575     
Arg Leu Asp Glu Ile Leu Ser Arg Ile Ala Lys Glu Thr Glu Glu Ile
            580                 585                 590         
Lys Asp Leu Glu Glu Gln Leu Thr Glu Gly Gln Ile Ala Ala Asn Glu
        595                 600                 605             
Ala Leu Lys Lys Asp Leu Glu Gly Val Ile Ser Gly Leu Gln Glu Tyr
    610                 615                 620                 
Leu Gly Thr Ile Lys Gly Gln Ala Thr Gln Ala Gln Asn Glu Cys Arg
625                 630                 635                 640 
Lys Leu Arg Asp Glu Lys Glu Thr Leu Leu Gln Arg Leu Thr Glu Val
                645                 650                 655     
Glu Gln Glu Arg Asp Gln Leu Glu Ile Val Ala Met Asp Ala Glu Asn
            660                 665                 670         
Met Arg Lys Glu Leu Ala Glu Leu Glu Ser Ala Leu Gln Glu Gln His
        675                 680                 685             
Glu Val Asn Ala Ser Leu Gln Gln Thr Gln Gly Asp Leu Ser Ala Tyr
    690                 695                 700                 
Glu Ala Glu Leu Glu Ala Arg Leu Asn Leu Arg Asp Ala Glu Ala Asn
705                 710                 715                 720 
Gln Leu Lys Glu Glu Leu Glu Lys Val Thr Arg Leu Thr Gln Leu Glu
                725                 730                 735     
Gln Ser Ala Leu Gln Ala Glu Leu Glu Lys Glu Arg Gln Ala Leu Lys
            740                 745                 750         
Asn Ala Leu Gly Lys Ala Gln Phe Ser Glu Glu Lys Glu Gln Glu Asn
        755                 760                 765             
Ser Glu Leu His Ala Lys Leu Lys His Leu Gln Asp Asp Asn Asn Leu
    770                 775                 780                 
Leu Lys Gln Gln Leu Lys Asp Phe Gln Asn His Leu Asn His Val Val
785                 790                 795                 800 
Asp Gly Leu Val Arg Pro Glu Glu Val Ala Ala Arg Val Asp Glu Leu
                805                 810                 815     
Arg Arg Lys Leu Lys Leu Gly Thr Gly Glu Met Asn Ile His Ser Pro
            820                 825                 830         
Ser Asp Val Leu Gly Lys Ser Leu Ala Asp Leu Gln Lys Gln Phe Ser
        835                 840                 845             
Glu Ile Leu Ala Arg Ser Lys Trp Glu Arg Asp Glu Ala Gln Val Arg
    850                 855                 860                 
Glu Arg Lys Leu Gln Glu Glu Met Ala Leu Gln Gln Glu Lys Leu Ala
865                 870                 875                 880 
Thr Gly Gln Glu Glu Phe Arg Gln Ala Cys Glu Arg Ala Leu Glu Ala
                885                 890                 895     
Arg Met Asn Phe Asp Lys Arg Gln His Glu Ala Arg Ile Gln Gln Met
            900                 905                 910         
Glu Asn Glu Ile His Tyr Leu Gln Glu Asn Leu Lys Ser Met Glu Glu
        915                 920                 925             
Ile Gln Gly Leu Thr Asp Leu Gln Leu Gln Glu Ala Asp Glu Glu Lys
    930                 935                 940                 
Glu Arg Ile Leu Ala Gln Leu Arg Glu Leu Glu Lys Lys Lys Lys Leu
945                 950                 955                 960 
Glu Asp Ala Lys Ser Gln Glu Gln Val Phe Gly Leu Asp Lys Glu Leu
                965                 970                 975     
Lys Lys Leu Lys Lys Ala Val Ala Thr Ser Asp Lys Leu Ala Thr Ala
            980                 985                 990         
Glu Leu Thr Ile Ala Lys Asp Gln Leu Lys Ser Leu His Gly Thr Val
        995                 1000                1005            
Met Lys Ile Asn Gln Glu Arg Ala Glu Glu Leu Gln Glu Ala Glu Arg
    1010                1015                1020                
Phe Ser Arg Lys Ala Ala Gln Ala Ala Arg Asp Leu Thr Arg Ala Glu
1025                1030                1035                1040
Ala Glu Ile Glu Leu Leu Gln Asn Leu Leu Arg Gln Lys Gly Glu Gln
                1045                1050                1055    
Phe Arg Leu Glu Met Glu Lys Thr Gly Val Gly Thr Gly Ala Asn Ser
            1060                1065                1070        
Gln Val Leu Glu Ile Glu Lys Leu Asn Glu Thr Met Glu Arg Gln Arg
        1075                1080                1085            
Thr Glu Ile Ala Arg Leu Gln Asn Val Leu Asp Leu Thr Gly Ser Asp
    1090                1095                1100                
Asn Lys Gly Gly Phe Glu Asn Val Leu Glu Glu Ile Ala Glu Leu Arg
1105                1110                1115                1120
Arg Glu Val Ser Tyr Gln Asn Asp Tyr Ile Ser Ser Met Ala Asp Pro
                1125                1130                1135    
Phe Lys Arg Arg Gly Tyr Trp Tyr Phe Met Pro Pro Pro Pro Ser Ser
            1140                1145                1150        
Lys Val Ser Ser His Ser Ser Gln Ala Thr Lys Asp Ser Gly Val Gly
        1155                1160                1165            
Leu Lys Tyr Ser Ala Ser Thr Pro Val Arg Lys Pro Arg Pro Gly Gln
    1170                1175                1180                
Gln Asp Gly Lys Glu Gly Ser Gln Pro Pro Pro Ala Ser Gly Tyr Trp
1185                1190                1195                1200
Val Tyr Ser Pro Ile Arg Ser Gly Leu His Lys Leu Phe Pro Ser Arg
                1205                1210                1215    
Asp Ala Asp Ser Gly Gly Asp Ser Gln Glu Glu Ser Glu Leu Asp Asp
            1220                1225                1230        
Gln Glu Glu Pro Pro Phe Val Pro Pro Pro Gly Tyr Met Met Tyr Thr
        1235                1240                1245            
Val Leu Pro Asp Gly Ser Pro Val Pro Gln Gly Met Ala Leu Tyr Ala
    1250                1255                1260                
Pro Pro Pro Pro Leu Pro Asn Asn Ser Arg Pro Leu Thr Pro Gly Thr
1265                1270                1275                1280
Val Val Tyr Gly Pro Pro Pro Ala Gly Ala Pro Met Val Tyr Gly Pro
                1285                1290                1295    
Pro Pro Pro Asn Phe Ser Ile Pro Phe Ile Pro Met Gly Val Leu His
            1300                1305                1310        
Cys Asn Val Pro Glu His His Asn Leu Glu Asn Glu Val Ser Arg Leu
        1315                1320                1325            
Glu Asp Ile Met Gln His Leu Lys Ser Lys Lys Arg Glu Glu Arg Trp
    1330                1335                1340                
Met Arg Ala Ser Lys Arg Gln Ser Glu Lys Glu Met Glu Glu Leu His
1345                1350                1355                1360
His Asn Ile Asp Asp Leu Leu Gln Glu Lys Lys Ser Leu Glu Cys Glu
                1365                1370                1375    
Val Glu Glu Leu His Arg Thr Val Gln Lys Arg Gln Gln Gln Lys Asp
            1380                1385                1390        
Phe Ile Asp Gly Asn Val Glu Ser Leu Met Thr Glu Leu Glu Ile Glu
        1395                1400                1405            
Lys Ser Leu Lys His His Glu Asp Ile Val Asp Glu Ile Glu Cys Ile
    1410                1415                1420                
Glu Lys Thr Leu Leu Lys Arg Arg Ser Glu Leu Arg Glu Ala Asp Arg
1425                1430                1435                1440
Leu Leu Ala Glu Ala Glu Ser Glu Leu Ser Cys Thr Lys Glu Lys Thr
                1445                1450                1455    
Lys Asn Ala Val Glu Lys Phe Thr Asp Ala Lys Arg Ser Leu Leu Gln
            1460                1465                1470        
Thr Glu Ser Asp Ala Glu Glu Leu Glu Arg Arg Ala Gln Glu Thr Ala
        1475                1480                1485            
Val Asn Leu Val Lys Ala Asp Gln Gln Leu Arg Ser Leu Gln Ala Asp
    1490                1495                1500                
Ala Lys Asp Leu Glu Gln His Lys Ile Lys Gln Glu Glu Ile Leu Lys
1505                1510                1515                1520
Glu Ile Asn Lys Ile Val Ala Ala Lys Asp Ser Asp Phe Gln Cys Leu
                1525                1530                1535    
Ser Lys Lys Lys Glu Lys Leu Thr Glu Glu Leu Gln Lys Leu Gln Lys
            1540                1545                1550        
Asp Ile Glu Met Ala Glu Arg Asn Glu Asp His His Leu Gln Val Leu
        1555                1560                1565            
Lys Glu Ser Glu Val Leu Leu Gln Ala Lys Arg Ala Glu Leu Glu Lys
    1570                1575                1580                
Leu Lys Ser Gln Val Thr Ser Gln Gln Gln Glu Met Ala Val Leu Asp
1585                1590                1595                1600
Arg Gln Leu Gly His Lys Lys Glu Glu Leu His Leu Leu Gln Gly Ser
                1605                1610                1615    
Met Val Gln Ala Lys Ala Asp Leu Gln Glu Ala Leu Arg Leu Gly Glu
            1620                1625                1630        
Thr Glu Val Thr Glu Lys Cys Asn His Ile Arg Glu Val Lys Ser Leu
        1635                1640                1645            
Leu Glu Glu Leu Ser Phe Gln Lys Gly Glu Leu Asn Val Gln Ile Ser
    1650                1655                1660                
Glu Arg Lys Thr Gln Leu Thr Leu Ile Lys Gln Glu Ile Glu Lys Glu
1665                1670                1675                1680
Glu Glu Asn Leu Gln Val Val Leu Arg Gln Met Ser Lys His Lys Thr
                1685                1690                1695    
Glu Leu Lys Asn Ile Leu Asp Met Leu Gln Leu Glu Asn His Glu Leu
            1700                1705                1710        
Gln Gly Leu Lys Leu Gln His Asp Gln Arg Val Ser Glu Leu Glu Lys
        1715                1720                1725            
Thr Gln Val Ala Val Leu Glu Glu Lys Leu Glu Leu Glu Asn Leu Gln
    1730                1735                1740                
Gln Ile Ser Gln Gln Gln Lys Gly Glu Ile Glu Trp Gln Lys Gln Leu
1745                1750                1755                1760
Leu Glu Arg Asp Lys Arg Glu Ile Glu Arg Met Thr Ala Glu Ser Arg
                1765                1770                1775    
Ala Leu Gln Ser Cys Val Glu Cys Leu Ser Lys Glu Lys Glu Asp Leu
            1780                1785                1790        
Gln Glu Lys Cys Asp Ile Trp Glu Lys Lys Leu Ala Gln Thr Lys Arg
        1795                1800                1805            
Val Leu Ala Ala Ala Glu Glu Asn Ser Lys Met Glu Gln Ser Asn Leu
    1810                1815                1820                
Glu Lys Leu Glu Leu Asn Val Arg Lys Leu Gln Gln Glu Leu Asp Gln
1825                1830                1835                1840
Leu Asn Arg Asp Lys Leu Ser Leu His Asn Asp Ile Ser Ala Met Gln
                1845                1850                1855    
Gln Gln Leu Gln Glu Lys Arg Glu Ala Val Asn Ser Leu Gln Glu Glu
            1860                1865                1870        
Leu Ala Asn Val Gln Asp His Leu Asn Leu Ala Lys Gln Asp Leu Leu
        1875                1880                1885            
His Thr Thr Lys His Gln Asp Val Leu Leu Ser Glu Gln Thr Arg Leu
    1890                1895                1900                
Gln Lys Asp Ile Ser Glu Trp Ala Asn Arg Phe Glu Asp Cys Gln Lys
1905                1910                1915                1920
Glu Glu Glu Thr Lys Gln Gln Gln Leu Gln Val Leu Gln Asn Glu Ile
                1925                1930                1935    
Glu Glu Asn Lys Leu Lys Leu Val Gln Gln Glu Met Met Phe Gln Arg
            1940                1945                1950        
Leu Gln Lys Glu Arg Glu Ser Glu Glu Ser Lys Leu Glu Thr Ser Lys
        1955                1960                1965            
Val Thr Leu Lys Glu Gln Gln His Gln Leu Glu Lys Glu Leu Thr Asp
    1970                1975                1980                
Gln Lys Ser Lys Leu Asp Gln Val Leu Ser Lys Val Leu Ala Ala Glu
1985                1990                1995                2000
Glu Arg Val Arg Thr Leu Gln Glu Glu Glu Arg Trp Cys Glu Ser Leu
                2005                2010                2015    
Glu Lys Thr Leu Ser Gln Thr Lys Arg Gln Leu Ser Glu Arg Glu Gln
            2020                2025                2030        
Gln Leu Val Glu Lys Ser Gly Glu Leu Leu Ala Leu Gln Lys Glu Ala
        2035                2040                2045            
Asp Ser Met Arg Ala Asp Phe Ser Leu Leu Arg Asn Gln Phe Leu Thr
    2050                2055                2060                
Glu Arg Lys Lys Ala Glu Lys Gln Val Ala Ser Leu Lys Glu Ala Leu
2065                2070                2075                2080
Lys Ile Gln Arg Ser Gln Leu Glu Lys Asn Leu Leu Glu Gln Lys Gln
                2085                2090                2095    
Glu Asn Ser Cys Ile Gln Lys Glu Met Ala Thr Ile Glu Leu Val Ala
            2100                2105                2110        
Gln Asp Asn His Glu Arg Ala Arg Arg Leu Met Lys Glu Leu Asn Gln
        2115                2120                2125            
Met Gln Tyr Glu Tyr Thr Glu Leu Lys Lys Gln Met Ala Asn Gln Lys
    2130                2135                2140                
Asp Leu Glu Arg Arg Gln Met Glu Ile Ser Asp Ala Met Arg Thr Leu
2145                2150                2155                2160
Lys Ser Glu Val Lys Asp Glu Ile Arg Thr Ser Leu Lys Asn Leu Asn
                2165                2170                2175    
Gln Phe Leu Pro Glu Leu Pro Ala Asp Leu Glu Ala Ile Leu Glu Arg
            2180                2185                2190        
Asn Glu Asn Leu Glu Gly Glu Leu Glu Ser Leu Lys Glu Asn Leu Pro
        2195                2200                2205            
Phe Thr Met Asn Glu Gly Pro Phe Glu Glu Lys Leu Asn Phe Ser Gln
    2210                2215                2220                
Val His Ile Met Asp Glu His Trp Arg Gly Glu Ala Leu Arg Glu Lys
2225                2230                2235                2240
Leu Arg His Arg Glu Asp Arg Leu Lys Ala Gln Leu Arg His Cys Met
                2245                2250                2255    
Ser Lys Gln Ala Glu Val Leu Ile Lys Gly Lys Arg Gln Thr Glu Gly
            2260                2265                2270        
Thr Leu His Ser Leu Arg Arg Gln Val Asp Ala Leu Gly Glu Leu Val
        2275                2280                2285            
Thr Ser Thr Ser Ala Asp Ser Ala Ser Ser Pro Ser Leu Ser Gln Leu
    2290                2295                2300                
Glu Ser Ser Leu Thr Glu Asp Ser Gln Leu Gly Gln Asn Gln Glu Lys
2305                2310                2315                2320
Asn Ala Ser Ala Arg
                2325


<210> 8209
<211> 906
<212> PRT
<213> Homo sapiens

<400> 8209
Leu Asp Arg His Trp Thr Gly Pro Ala Gly Val Ser Thr Glu Thr Ile
 1               5                  10                  15      
Arg Met Ser Tyr Phe Gly Glu His Phe Trp Gly Glu Lys Asn His Gly
            20                  25                  30          
Phe Glu Val Leu Tyr His Ser Val Lys Gln Gly Pro Ile Ser Thr Lys
        35                  40                  45              
Glu Leu Ala Asp Phe Ile Arg Glu Arg Ala Thr Ile Glu Glu Thr Tyr
    50                  55                  60                  
Ser Lys Ala Met Ala Lys Leu Ser Lys Leu Ala Ser Asn Gly Thr Pro
65                  70                  75                  80  
Met Gly Thr Phe Ala Pro Leu Trp Glu Val Phe Arg Val Ser Ser Asp
                85                  90                  95      
Lys Leu Ala Leu Cys His Leu Glu Leu Thr Arg Lys Leu Gln Asp Leu
            100                 105                 110         
Ile Lys Asp Val Leu Arg Tyr Gly Glu Glu Gln Leu Lys Thr His Lys
        115                 120                 125             
Lys Cys Lys Glu Glu Val Val Ser Thr Leu Asp Ala Val Gln Val Leu
    130                 135                 140                 
Ser Gly Val Ser Gln Leu Leu Pro Lys Ser Arg Glu Asn Tyr Leu Asn
145                 150                 155                 160 
Arg Cys Met Asp Gln Glu Arg Leu Arg Arg Glu Ser Thr Ser Gln Lys
                165                 170                 175     
Glu Met Asp Lys Ala Glu Thr Lys Thr Lys Lys Ala Ala Glu Ser Leu
            180                 185                 190         
Arg Arg Ser Val Glu Lys Tyr Asn Ser Ala Arg Ala Asp Phe Glu Gln
        195                 200                 205             
Lys Met Leu Asp Ser Ala Leu Arg Phe Gln Ala Met Glu Glu Thr His
    210                 215                 220                 
Leu Arg His Met Lys Ala Leu Leu Gly Ser Tyr Ala His Ser Val Glu
225                 230                 235                 240 
Asp Thr His Val Gln Ile Gly Gln Val His Glu Glu Phe Lys Gln Asn
                245                 250                 255     
Ile Glu Asn Val Ser Val Glu Met Leu Leu Arg Lys Phe Ala Glu Ser
            260                 265                 270         
Lys Gly Thr Gly Arg Glu Lys Pro Gly Pro Leu Asp Phe Glu Ala Tyr
        275                 280                 285             
Ser Ala Ala Ala Leu Gln Glu Ala Met Lys Arg Leu Arg Gly Ala Lys
    290                 295                 300                 
Ala Phe Arg Leu Pro Gly Leu Ser Arg Arg Glu Arg Glu Pro Glu Pro
305                 310                 315                 320 
Pro Ala Ala Val Asp Phe Leu Glu Pro Asp Ser Gly Thr Cys Pro Glu
                325                 330                 335     
Val Asp Glu Glu Gly Phe Thr Val Arg Pro Asp Val Thr Gln Asn Ser
            340                 345                 350         
Thr Ala Glu Pro Ser Arg Phe Ser Ser Ser Asp Ser Asp Phe Asp Asp
        355                 360                 365             
Glu Glu Pro Arg Lys Phe Tyr Val His Ile Lys Pro Ala Pro Ala Arg
    370                 375                 380                 
Ala Pro Ala Cys Ser Pro Glu Ala Ala Ala Ala Gln Leu Arg Ala Thr
385                 390                 395                 400 
Ala Gly Ser Leu Ile Leu Pro Pro Gly Pro Gly Gly Thr Met Lys Arg
                405                 410                 415     
His Ser Ser Arg Asp Ala Ala Gly Lys Pro Gln Arg Pro Arg Ser Ala
            420                 425                 430         
Pro Arg Thr Ser Ser Cys Ala Glu Arg Leu Gln Ser Glu Glu Gln Val
        435                 440                 445             
Ser Lys Asn Leu Phe Gly Pro Pro Leu Glu Ser Ala Phe Asp His Glu
    450                 455                 460                 
Asp Phe Thr Gly Ser Ser Ser Leu Gly Phe Thr Ser Ser Pro Ser Pro
465                 470                 475                 480 
Phe Ser Ser Ser Ser Pro Glu Asn Val Glu Asp Ser Gly Leu Asp Ser
                485                 490                 495     
Pro Ser His Ala Ala Pro Gly Pro Ser Pro Asp Ser Trp Val Pro Arg
            500                 505                 510         
Pro Gly Thr Pro Gln Ser Pro Pro Ser Cys Arg Ala Pro Pro Pro Glu
        515                 520                 525             
Ala Arg Gly Ile Arg Ala Pro Pro Leu Pro Asp Ser Pro Gln Pro Leu
    530                 535                 540                 
Ala Ser Ser Pro Gly Pro Trp Gly Leu Glu Ala Leu Ala Gly Gly Asp
545                 550                 555                 560 
Leu Met Pro Ala Pro Ala Asp Pro Thr Ala Arg Glu Gly Leu Ala Ala
                565                 570                 575     
Pro Pro Arg Arg Leu Arg Ser Arg Lys Val Ser Cys Pro Leu Thr Arg
            580                 585                 590         
Ser Asn Gly Asp Leu Ser Arg Ser Leu Ser Pro Ser Pro Leu Gly Ser
        595                 600                 605             
Ser Ala Ala Ser Thr Ala Leu Glu Arg Pro Ser Phe Leu Ser Gln Thr
    610                 615                 620                 
Gly His Gly Val Ser Arg Gly Pro Ser Pro Val Val Leu Gly Ser Gln
625                 630                 635                 640 
Asp Ala Leu Pro Ile Ala Thr Ala Phe Thr Glu Tyr Val His Ala Tyr
                645                 650                 655     
Phe Arg Gly His Ser Pro Ser Cys Leu Ala Arg Val Thr Gly Glu Leu
            660                 665                 670         
Thr Met Thr Phe Pro Ala Gly Ile Val Arg Val Phe Ser Gly Thr Pro
        675                 680                 685             
Pro Pro Pro Val Leu Ser Phe Arg Leu Val His Thr Thr Ala Ile Glu
    690                 695                 700                 
His Phe Gln Pro Asn Ala Asp Leu Leu Phe Ser Asp Pro Ser Gln Ser
705                 710                 715                 720 
Asp Pro Glu Thr Lys Asp Phe Trp Leu Asn Met Ala Ala Leu Thr Glu
                725                 730                 735     
Ala Leu Gln Arg Gln Ala Glu Gln Asn Pro Thr Ala Ser Tyr Tyr Asn
            740                 745                 750         
Val Val Leu Leu Arg Tyr Gln Phe Ser Arg Pro Gly Pro Gln Ser Val
        755                 760                 765             
Pro Leu Gln Leu Ser Ala His Trp Gln Cys Gly Ala Thr Leu Thr Gln
    770                 775                 780                 
Val Ser Val Glu Tyr Gly Tyr Arg Pro Gly Ala Thr Ala Val Pro Thr
785                 790                 795                 800 
Pro Leu Thr Asn Val Gln Ile Leu Leu Pro Val Gly Glu Pro Val Thr
                805                 810                 815     
Asn Val Arg Leu Gln Pro Ala Ala Thr Trp Asn Leu Glu Glu Lys Arg
            820                 825                 830         
Leu Thr Trp Arg Leu Pro Asp Val Ser Glu Ala Gly Gly Ser Gly Arg
        835                 840                 845             
Leu Ser Ala Ser Trp Glu Pro Leu Ser Gly Pro Ser Thr Pro Ser Pro
    850                 855                 860                 
Val Ala Ala Gln Phe Thr Ser Glu Gly Thr Thr Leu Ser Gly Val Asp
865                 870                 875                 880 
Leu Glu Leu Val Gly Ser Gly Tyr Arg Met Ser Leu Val Lys Arg Arg
                885                 890                 895     
Phe Ala Thr Gly Met Tyr Leu Val Ser Cys
            900                 905     


<210> 8210
<211> 889
<212> PRT
<213> Homo sapiens

<400> 8210
Met Ser Tyr Phe Gly Glu His Phe Trp Gly Glu Lys Asn His Gly Phe
 1               5                  10                  15      
Glu Val Leu Tyr His Ser Val Lys Gln Gly Pro Ile Ser Thr Lys Glu
            20                  25                  30          
Leu Ala Asp Phe Ile Arg Glu Arg Ala Thr Ile Glu Glu Thr Tyr Ser
        35                  40                  45              
Lys Ala Met Ala Lys Leu Ser Lys Leu Ala Ser Asn Gly Thr Pro Met
    50                  55                  60                  
Gly Thr Phe Ala Pro Leu Trp Glu Val Phe Arg Val Ser Ser Asp Lys
65                  70                  75                  80  
Leu Ala Leu Cys His Leu Glu Leu Thr Arg Lys Leu Gln Asp Leu Ile
                85                  90                  95      
Lys Asp Val Leu Arg Tyr Gly Glu Glu Gln Leu Lys Thr His Lys Lys
            100                 105                 110         
Cys Lys Glu Glu Val Val Ser Thr Leu Asp Ala Val Gln Val Leu Ser
        115                 120                 125             
Gly Val Ser Gln Leu Leu Pro Lys Ser Arg Glu Asn Tyr Leu Asn Arg
    130                 135                 140                 
Cys Met Asp Gln Glu Arg Leu Arg Arg Glu Ser Thr Ser Gln Lys Glu
145                 150                 155                 160 
Met Asp Lys Ala Glu Thr Lys Thr Lys Lys Ala Ala Glu Ser Leu Arg
                165                 170                 175     
Arg Ser Val Glu Lys Tyr Asn Ser Ala Arg Ala Asp Phe Glu Gln Lys
            180                 185                 190         
Met Leu Asp Ser Ala Leu Arg Phe Gln Ala Met Glu Glu Thr His Leu
        195                 200                 205             
Arg His Met Lys Ala Leu Leu Gly Ser Tyr Ala His Ser Val Glu Asp
    210                 215                 220                 
Thr His Val Gln Ile Gly Gln Val His Glu Glu Phe Lys Gln Asn Ile
225                 230                 235                 240 
Glu Asn Val Ser Val Glu Met Leu Leu Arg Lys Phe Ala Glu Ser Lys
                245                 250                 255     
Gly Thr Gly Arg Glu Lys Pro Gly Pro Leu Asp Phe Glu Ala Tyr Ser
            260                 265                 270         
Ala Ala Ala Leu Gln Glu Ala Met Lys Arg Leu Arg Gly Ala Lys Ala
        275                 280                 285             
Phe Arg Leu Pro Gly Leu Ser Arg Arg Glu Arg Glu Pro Glu Pro Pro
    290                 295                 300                 
Ala Ala Val Asp Phe Leu Glu Pro Asp Ser Gly Thr Cys Pro Glu Val
305                 310                 315                 320 
Asp Glu Glu Gly Phe Thr Val Arg Pro Asp Val Thr Gln Asn Ser Thr
                325                 330                 335     
Ala Glu Pro Ser Arg Phe Ser Ser Ser Asp Ser Asp Phe Asp Asp Glu
            340                 345                 350         
Glu Pro Arg Lys Phe Tyr Val His Ile Lys Pro Ala Pro Ala Arg Ala
        355                 360                 365             
Pro Ala Cys Ser Pro Glu Ala Ala Ala Ala Gln Leu Arg Ala Thr Ala
    370                 375                 380                 
Gly Ser Leu Ile Leu Pro Pro Gly Pro Gly Gly Thr Met Lys Arg His
385                 390                 395                 400 
Ser Ser Arg Asp Ala Ala Gly Lys Pro Gln Arg Pro Arg Ser Ala Pro
                405                 410                 415     
Arg Thr Ser Ser Cys Ala Glu Arg Leu Gln Ser Glu Glu Gln Val Ser
            420                 425                 430         
Lys Asn Leu Phe Gly Pro Pro Leu Glu Ser Ala Phe Asp His Glu Asp
        435                 440                 445             
Phe Thr Gly Ser Ser Ser Leu Gly Phe Thr Ser Ser Pro Ser Pro Phe
    450                 455                 460                 
Ser Ser Ser Ser Pro Glu Asn Val Glu Asp Ser Gly Leu Asp Ser Pro
465                 470                 475                 480 
Ser His Ala Ala Pro Gly Pro Ser Pro Asp Ser Trp Val Pro Arg Pro
                485                 490                 495     
Gly Thr Pro Gln Ser Pro Pro Ser Cys Arg Ala Pro Pro Pro Glu Ala
            500                 505                 510         
Arg Gly Ile Arg Ala Pro Pro Leu Pro Asp Ser Pro Gln Pro Leu Ala
        515                 520                 525             
Ser Ser Pro Gly Pro Trp Gly Leu Glu Ala Leu Ala Gly Gly Asp Leu
    530                 535                 540                 
Met Pro Ala Pro Ala Asp Pro Thr Ala Arg Glu Gly Leu Ala Ala Pro
545                 550                 555                 560 
Pro Arg Arg Leu Arg Ser Arg Lys Val Ser Cys Pro Leu Thr Arg Ser
                565                 570                 575     
Asn Gly Asp Leu Ser Arg Ser Leu Ser Pro Ser Pro Leu Gly Ser Ser
            580                 585                 590         
Ala Ala Ser Thr Ala Leu Glu Arg Pro Ser Phe Leu Ser Gln Thr Gly
        595                 600                 605             
His Gly Val Ser Arg Gly Pro Ser Pro Val Val Leu Gly Ser Gln Asp
    610                 615                 620                 
Ala Leu Pro Ile Ala Thr Ala Phe Thr Glu Tyr Val His Ala Tyr Phe
625                 630                 635                 640 
Arg Gly His Ser Pro Ser Cys Leu Ala Arg Val Thr Gly Glu Leu Thr
                645                 650                 655     
Met Thr Phe Pro Ala Gly Ile Val Arg Val Phe Ser Gly Thr Pro Pro
            660                 665                 670         
Pro Pro Val Leu Ser Phe Arg Leu Val His Thr Thr Ala Ile Glu His
        675                 680                 685             
Phe Gln Pro Asn Ala Asp Leu Leu Phe Ser Asp Pro Ser Gln Ser Asp
    690                 695                 700                 
Pro Glu Thr Lys Asp Phe Trp Leu Asn Met Ala Ala Leu Thr Glu Ala
705                 710                 715                 720 
Leu Gln Arg Gln Ala Glu Gln Asn Pro Thr Ala Ser Tyr Tyr Asn Val
                725                 730                 735     
Val Leu Leu Arg Tyr Gln Phe Ser Arg Pro Gly Pro Gln Ser Val Pro
            740                 745                 750         
Leu Gln Leu Ser Ala His Trp Gln Cys Gly Ala Thr Leu Thr Gln Val
        755                 760                 765             
Ser Val Glu Tyr Gly Tyr Arg Pro Gly Ala Thr Ala Val Pro Thr Pro
    770                 775                 780                 
Leu Thr Asn Val Gln Ile Leu Leu Pro Val Gly Glu Pro Val Thr Asn
785                 790                 795                 800 
Val Arg Leu Gln Pro Ala Ala Thr Trp Asn Leu Glu Glu Lys Arg Leu
                805                 810                 815     
Thr Trp Arg Leu Pro Asp Val Ser Glu Ala Gly Gly Ser Gly Arg Leu
            820                 825                 830         
Ser Ala Ser Trp Glu Pro Leu Ser Gly Pro Ser Thr Pro Ser Pro Val
        835                 840                 845             
Ala Ala Gln Phe Thr Ser Glu Gly Thr Thr Leu Ser Gly Val Asp Leu
    850                 855                 860                 
Glu Leu Val Gly Ser Gly Tyr Arg Met Ser Leu Val Lys Arg Arg Phe
865                 870                 875                 880 
Ala Thr Gly Met Tyr Leu Val Ser Cys
                885                 


<210> 8211
<211> 1783
<212> PRT
<213> Homo sapiens

<400> 8211
Lys Gln Lys Asp Tyr Ser His Val Arg His Phe Leu Pro Asn Asp Leu
 1               5                  10                  15      
Glu Lys Ser Asn Gly Ser Asn Ala Leu Asp Met Glu Lys Tyr Leu Lys
            20                  25                  30          
Lys Thr Glu Val Ser Arg Tyr Glu Ser Ala Leu Glu Asn Phe Ser Arg
        35                  40                  45              
Ala Ser Met Ser Asp Thr Trp Asp Leu Ser Leu Pro Lys Glu Gln Thr
    50                  55                  60                  
Thr Gln Asp Ile His Pro Val Asp Leu Ser Ala Thr Ser Val Ser Val
65                  70                  75                  80  
Arg Ala Pro Glu Glu Asn Thr Ala Ala Ile Val Tyr Val Glu Asn Gly
                85                  90                  95      
Glu Ser Glu Asn Gln Glu Ser Phe Arg Thr Ile Asn Ser Ser Asn Ser
            100                 105                 110         
Val Thr Asn Arg Glu Asn Asn Ser Ala Val Val Asp Val Lys Thr Cys
        115                 120                 125             
Ser Ile Asp Asn Lys Leu Gln Asp Val Gly Asn Asp Glu Lys Ala Thr
    130                 135                 140                 
Ser Ile Ser Thr Pro Ser Asp Ser Tyr Ser Ser Val Arg Asn Pro Arg
145                 150                 155                 160 
Ile Thr Ser Leu Cys Leu Leu Lys Asp Cys Glu Glu Ile Arg Asp Asn
                165                 170                 175     
Arg Glu Asn Gln Arg Gln Asn Glu Cys Val Ser Glu Ile Ser Asn Ser
            180                 185                 190         
Glu Lys His Val Thr Phe Glu Asn His Arg Ile Val Ser Pro Lys Asn
        195                 200                 205             
Ser Asp Leu Lys Asn Thr Ser Pro Glu His Gly Gly Arg Gly Ser Glu
    210                 215                 220                 
Asp Glu Gln Glu Ser Phe Arg Pro Ser Thr Ser Pro Leu Ser His Ser
225                 230                 235                 240 
Ser Pro Ser Glu Ile Ser Gly Thr Ser Ser Ser Gly Cys Ala Leu Glu
                245                 250                 255     
Ser Phe Gly Ser Ala Ala Gln Gln Gln Gln Pro Pro Cys Glu Gln Glu
            260                 265                 270         
Leu Ser Pro Leu Val Cys Ser Pro Ala Gly Val Ser Arg Leu Thr Tyr
        275                 280                 285             
Val Ser Glu Pro Glu Ser Ser Tyr Pro Thr Thr Ala Thr Asp Asp Ala
    290                 295                 300                 
Leu Glu Asp Arg Lys Ser Asp Ile Thr Ser Glu Leu Ser Thr Thr Ile
305                 310                 315                 320 
Ile Gln Gly Ser Pro Ala Ala Leu Glu Glu Arg Ala Met Glu Lys Leu
                325                 330                 335     
Arg Glu Lys Val Pro Phe Gln Asn Arg Gly Lys Gly Thr Leu Ser Ser
            340                 345                 350         
Ile Ile Gln Asn Asn Ser Asp Thr Arg Lys Ala Thr Glu Thr Thr Ser
        355                 360                 365             
Leu Ser Ser Lys Pro Glu Tyr Val Lys Pro Asp Phe Arg Trp Ser Lys
    370                 375                 380                 
Asp Pro Ser Ser Lys Ser Gly Asn Leu Leu Glu Thr Ser Glu Val Gly
385                 390                 395                 400 
Trp Thr Ser Asn Pro Glu Glu Leu Asp Pro Ile Arg Leu Ala Leu Leu
                405                 410                 415     
Gly Lys Ser Gly Leu Ser Cys Gln Val Gly Ser Ala Thr Ser His Pro
            420                 425                 430         
Val Ser Cys Gln Glu Pro Ile Asp Glu Asp Gln Arg Ile Ser Pro Lys
        435                 440                 445             
Asp Lys Ser Thr Ala Gly Arg Glu Phe Ser Gly Gln Val Ser His Gln
    450                 455                 460                 
Thr Thr Ser Glu Asn Gln Cys Thr Pro Ile Pro Ser Ser Thr Val His
465                 470                 475                 480 
Ser Ser Val Ala Asp Met Gln Asn Met Pro Ala Ala Val His Ala Leu
                485                 490                 495     
Leu Thr Gln Pro Ser Leu Ser Ala Ala Pro Phe Ala Gln Arg Tyr Leu
            500                 505                 510         
Gly Thr Leu Pro Ser Thr Gly Ser Thr Thr Leu Pro Gln Cys His Ala
        515                 520                 525             
Gly Asn Ala Thr Val Cys Gly Phe Ser Gly Gly Leu Pro Tyr Pro Ala
    530                 535                 540                 
Val Ala Gly Glu Pro Val Gln Asn Ser Val Ala Val Gly Ile Cys Leu
545                 550                 555                 560 
Gly Ser Asn Ile Gly Ser Gly Trp Met Gly Thr Ser Ser Leu Cys Asn
                565                 570                 575     
Pro Tyr Ser Asn Thr Leu Asn Gln Asn Leu Leu Ser Thr Thr Lys Pro
            580                 585                 590         
Phe Pro Val Pro Ser Val Gly Thr Asn Cys Gly Ile Glu Pro Trp Asp
        595                 600                 605             
Ser Gly Val Thr Ser Gly Leu Gly Ser Val Arg Val Pro Glu Glu Leu
    610                 615                 620                 
Lys Leu Pro His Ala Cys Cys Val Gly Ile Ala Ser Gln Thr Leu Leu
625                 630                 635                 640 
Ser Val Leu Asn Pro Thr Asp Arg Trp Leu Gln Val Ser Ile Gly Val
                645                 650                 655     
Leu Ser Ile Ser Val Asn Gly Glu Lys Val Asp Leu Ser Thr Tyr Arg
            660                 665                 670         
Cys Leu Val Phe Lys Asn Lys Ala Ile Ile Arg Pro His Ala Thr Glu
        675                 680                 685             
Glu Ile Lys Val Leu Phe Ile Pro Ser Ser Pro Gly Val Phe Arg Cys
    690                 695                 700                 
Thr Phe Ser Val Ala Ser Trp Pro Cys Ser Thr Asp Ala Glu Thr Ile
705                 710                 715                 720 
Val Gln Ala Glu Ala Leu Ala Ser Thr Val Thr Leu Thr Ala Ile Ala
                725                 730                 735     
Glu Ser Pro Val Ile Glu Val Glu Thr Glu Lys Lys Asp Val Leu Asp
            740                 745                 750         
Phe Gly Asp Leu Thr Tyr Gly Gly Trp Lys Ala Leu Pro Leu Lys Leu
        755                 760                 765             
Ile Asn Arg Thr His Ala Thr Val Pro Ile Arg Leu Ile Ile Asn Ala
    770                 775                 780                 
Asn Ala Val Ala Trp Arg Cys Phe Thr Phe Ser Lys Glu Ser Val Arg
785                 790                 795                 800 
Ala Pro Val Glu Val Ala Pro Cys Ala Asp Val Val Thr Arg Leu Ala
                805                 810                 815     
Gly Pro Ser Val Val Asn His Met Met Pro Ala Ser Tyr Asp Gly Gln
            820                 825                 830         
Asp Pro Glu Phe Leu Met Ile Trp Val Leu Phe His Ser Pro Lys Lys
        835                 840                 845             
Gln Ile Ser Ser Ser Asp Ile Leu Asp Ser Ala Glu Glu Phe Ser Ala
    850                 855                 860                 
Lys Val Asp Ile Glu Val Asp Ser Pro Asn Pro Thr Pro Val Leu Arg
865                 870                 875                 880 
Ser Val Ser Leu Arg Ala Arg Ala Gly Ile Ala Arg Ile His Ala Pro
                885                 890                 895     
Arg Asp Leu Gln Thr Met His Phe Leu Ala Lys Val Ala Ser Ser Arg
            900                 905                 910         
Lys Gln His Leu Pro Leu Lys Asn Ala Gly Asn Ile Glu Val Tyr Leu
        915                 920                 925             
Asp Ile Lys Val Pro Glu Gln Gly Ser His Phe Ser Val Asp Pro Lys
    930                 935                 940                 
Asn Leu Leu Leu Lys Pro Gly Glu Glu His Glu Val Ile Val Ser Phe
945                 950                 955                 960 
Thr Pro Lys Asp Pro Glu Ala Cys Glu Glu Arg Ile Leu Lys Ile Phe
                965                 970                 975     
Val Gln Pro Phe Gly Pro Gln Tyr Glu Val Val Leu Lys Gly Glu Val
            980                 985                 990         
Ile Ser Ser Gly Ser Lys Pro Leu Ser Pro Gly Pro Cys Leu Asp Ile
        995                 1000                1005            
Pro Ser Ile Leu Ser Asn Lys Gln Phe Leu Ala Trp Gly Gly Val Pro
    1010                1015                1020                
Leu Gly Arg Thr Gln Leu Gln Lys Leu Ala Leu Arg Asn Asn Ser Ala
1025                1030                1035                1040
Ser Thr Thr Gln His Leu Arg Leu Leu Ile Arg Gly Gln Asp Gln Asp
                1045                1050                1055    
Cys Phe Gln Leu Gln Asn Thr Phe Gly Ser Glu Gln Arg Leu Thr Ser
            1060                1065                1070        
Asn Cys Glu Ile Arg Ile His Pro Lys Glu Asp Ile Phe Ile Ser Val
        1075                1080                1085            
Leu Phe Ala Pro Thr Arg Leu Ser Cys Met Leu Ala Arg Leu Glu Ile
    1090                1095                1100                
Lys Gln Leu Gly Asn Arg Ser Gln Pro Gly Ile Lys Phe Thr Ile Pro
1105                1110                1115                1120
Leu Ser Gly Tyr Gly Gly Thr Ser Asn Leu Ile Leu Glu Gly Val Lys
                1125                1130                1135    
Lys Leu Ser Asp Ser Tyr Met Val Thr Val Asn Gly Leu Val Pro Gly
            1140                1145                1150        
Lys Glu Ser Lys Ile Val Phe Ser Val Arg Asn Thr Gly Ser Arg Ala
        1155                1160                1165            
Ala Phe Val Lys Ala Val Gly Phe Lys Asp Ser Gln Lys Lys Val Leu
    1170                1175                1180                
Leu Asp Pro Lys Val Leu Arg Ile Phe Pro Asp Lys Phe Val Leu Lys
1185                1190                1195                1200
Glu Arg Thr Gln Glu Asn Val Thr Leu Ile Tyr Asn Pro Ser Asp Arg
                1205                1210                1215    
Gly Ile Asn Asn Lys Thr Ala Thr Glu Leu Ser Thr Val Tyr Leu Phe
            1220                1225                1230        
Gly Gly Asp Glu Ile Ser Arg Gln Gln Tyr Arg Arg Ala Leu Leu His
        1235                1240                1245            
Lys Pro Glu Met Ile Lys Gln Ile Leu Pro Glu His Ser Val Leu Gln
    1250                1255                1260                
Asn Ile Asn Phe Val Glu Ala Phe Gln Asp Glu Leu Leu Val Thr Glu
1265                1270                1275                1280
Val Tyr Asp Leu Pro Gln Arg Pro Asn Asp Val Gln Leu Phe Tyr Gly
                1285                1290                1295    
Ser Met Cys Lys Ile Ile Leu Ser Val Ile Gly Glu Phe Arg Asp Cys
            1300                1305                1310        
Ile Ser Ser Arg Glu Phe Leu Gln Pro Ser Ser Lys Ala Ser Leu Glu
        1315                1320                1325            
Ser Thr Ser Asp Leu Gly Ala Ser Gly Lys His Gly Gly Asn Val Ser
    1330                1335                1340                
Leu Asp Val Leu Pro Val Lys Gly Pro Gln Gly Ser Pro Leu Leu Ser
1345                1350                1355                1360
Arg Ala Ala Arg Pro Pro Leu Asp Gln Leu Ala Ser Glu Glu Pro Trp
                1365                1370                1375    
Thr Val Leu Pro Glu His Leu Ile Leu Val Ala Pro Ser Pro Cys Asp
            1380                1385                1390        
Met Ala Lys Thr Gly Arg Phe Gln Ile Val Asn Asn Ser Val Arg Leu
        1395                1400                1405            
Leu Arg Phe Glu Leu Cys Trp Pro Ala His Cys Leu Thr Val Thr Pro
    1410                1415                1420                
Gln His Gly Cys Val Ala Pro Glu Ser Lys Leu Gln Ile Leu Val Ser
1425                1430                1435                1440
Pro Asn Ser Ser Leu Ser Thr Lys Gln Ser Met Phe Pro Trp Ser Gly
                1445                1450                1455    
Leu Ile Tyr Ile His Cys Asp Asp Gly Gln Lys Val Leu Val Lys Val
            1460                1465                1470        
Gln Ile Arg Glu Asp Leu Thr Gln Val Glu Leu Leu Thr Arg Leu Thr
        1475                1480                1485            
Ser Lys Pro Phe Gly Ile Leu Ser Pro Val Ser Glu Pro Ser Val Ser
    1490                1495                1500                
His Leu Val Lys Pro Met Thr Lys Pro Pro Ser Thr Lys Val Glu Ile
1505                1510                1515                1520
Arg Asn Lys Ser Ile Thr Phe Pro Thr Thr Glu Pro Gly Glu Thr Ser
                1525                1530                1535    
Glu Ser Cys Leu Glu Leu Glu Asn His Gly Thr Thr Asp Val Lys Trp
            1540                1545                1550        
His Leu Ser Ser Leu Ala Pro Pro Tyr Val Lys Gly Val Asp Glu Ser
        1555                1560                1565            
Gly Asp Val Phe Arg Ala Thr Tyr Ala Ala Phe Arg Cys Ser Pro Ile
    1570                1575                1580                
Ser Gly Leu Leu Glu Ser His Gly Ile Gln Lys Val Ser Ile Thr Phe
1585                1590                1595                1600
Leu Pro Arg Gly Arg Gly Asp Tyr Ala Gln Phe Trp Asp Val Glu Cys
                1605                1610                1615    
His Pro Leu Lys Glu Pro His Met Lys His Thr Leu Arg Phe Gln Leu
            1620                1625                1630        
Ser Gly Gln Ser Ile Glu Ala Glu Asn Glu Pro Glu Asn Ala Cys Leu
        1635                1640                1645            
Ser Thr Asp Ser Leu Ile Lys Ile Asp His Leu Val Lys Pro Arg Arg
    1650                1655                1660                
Gln Ala Val Ser Glu Ala Ser Ala Arg Ile Pro Glu Tyr Leu Asp Val
1665                1670                1675                1680
Thr Ala Arg Gly Val Tyr Ala Pro Glu Asp Val Tyr Arg Phe Arg Pro
                1685                1690                1695    
Thr Ser Val Gly Glu Ser Arg Thr Leu Lys Val Asn Leu Arg Asn Asn
            1700                1705                1710        
Ser Phe Ile Thr His Ser Leu Lys Phe Leu Ser Pro Arg Glu Pro Phe
        1715                1720                1725            
Tyr Val Lys His Ser Lys Tyr Ser Leu Arg Ala Gln His Tyr Ile Asn
    1730                1735                1740                
Met Pro Val Gln Phe Lys Pro Lys Ser Ala Gly Lys Phe Glu Ala Leu
1745                1750                1755                1760
Leu Val Ile Gln Thr Asp Glu Gly Lys Ser Ile Ala Ile Arg Leu Ile
                1765                1770                1775    
Gly Glu Ala Leu Gly Lys Asn
            1780            


<210> 8212
<211> 1923
<212> PRT
<213> Homo sapiens

<400> 8212
Met Phe Ser Arg Arg Ser His Gly Asp Val Lys Lys Ser Thr Gln Lys
 1               5                  10                  15      
Val Leu Asp Pro Lys Lys Asp Val Leu Thr Arg Leu Lys His Leu Arg
            20                  25                  30          
Ala Leu Leu Asp Asn Val Asp Ala Asn Asp Leu Lys Gln Phe Phe Glu
        35                  40                  45              
Thr Asn Tyr Ser Gln Ile Tyr Phe Ile Phe Tyr Glu Asn Phe Ile Ala
    50                  55                  60                  
Leu Glu Asn Ser Leu Lys Leu Lys Gly Asn Asn Lys Ser Gln Arg Glu
65                  70                  75                  80  
Glu Leu Asp Ser Ile Leu Phe Leu Phe Glu Lys Ile Leu Gln Phe Leu
                85                  90                  95      
Pro Glu Arg Ile Phe Phe Arg Trp His Tyr Gln Ser Ile Gly Ser Thr
            100                 105                 110         
Leu Lys Lys Leu Leu His Thr Gly Asn Ser Ile Lys Ile Arg Cys Glu
        115                 120                 125             
Gly Ile Arg Leu Phe Leu Leu Trp Leu Gln Ala Leu Gln Thr Asn Cys
    130                 135                 140                 
Ala Glu Glu Gln Val Leu Ile Phe Ala Cys Leu Val Pro Gly Phe Pro
145                 150                 155                 160 
Ala Val Met Ser Ser Arg Gly Pro Cys Thr Leu Glu Thr Leu Ile Asn
                165                 170                 175     
Pro Ser Pro Ser Val Ala Asp Val Lys Ile Tyr Pro Glu Glu Ile Thr
            180                 185                 190         
Pro Leu Leu Pro Ala Ile Ser Gly Glu Lys Ile Ala Glu Asp Gln Thr
        195                 200                 205             
Cys Phe Phe Leu Gln Ile Leu Leu Lys Tyr Met Val Ile Gln Ala Ala
    210                 215                 220                 
Ser Leu Glu Trp Lys Asn Lys Glu Asn Gln Asp Thr Gly Phe Lys Phe
225                 230                 235                 240 
Leu Phe Thr Leu Phe Arg Lys Tyr Tyr Leu Pro His Leu Phe Pro Ser
                245                 250                 255     
Phe Thr Lys Leu Thr Asn Ile Tyr Lys Pro Val Leu Asp Ile Pro His
            260                 265                 270         
Leu Arg Pro Lys Pro Val Tyr Ile Thr Thr Thr Arg Asp Asn Glu Asn
        275                 280                 285             
Ile Tyr Ser Thr Lys Ile Pro Tyr Met Ala Ala Arg Val Val Phe Ile
    290                 295                 300                 
Lys Trp Ile Val Thr Phe Phe Leu Glu Lys Lys Tyr Leu Thr Ala Thr
305                 310                 315                 320 
Gln Asn Thr Lys Asn Gly Val Asp Val Leu Pro Lys Ile Ile Gln Thr
                325                 330                 335     
Val Gly Gly Gly Ala Val Gln Glu Arg Ala Pro Glu Leu Asp Gly Gly
            340                 345                 350         
Gly Pro Thr Glu Gln Asp Lys Ser His Ser Asn Ser Ser Thr Leu Ser
        355                 360                 365             
Asp Arg Arg Leu Ser Asn Ser Ser Leu Cys Ser Ile Glu Glu Glu His
    370                 375                 380                 
Arg Met Val Tyr Glu Met Val Gln Arg Ile Leu Leu Ser Thr Arg Gly
385                 390                 395                 400 
Tyr Val Asn Phe Val Asn Glu Val Phe His Gln Ala Phe Leu Leu Pro
                405                 410                 415     
Ser Cys Glu Ile Ala Val Thr Arg Lys Val Val Gln Val Tyr Arg Lys
            420                 425                 430         
Trp Ile Leu Gln Asp Lys Pro Val Phe Met Glu Glu Pro Asp Arg Lys
        435                 440                 445             
Asp Val Ala Gln Glu Asp Ala Glu Lys Leu Gly Phe Ser Glu Thr Asp
    450                 455                 460                 
Ser Lys Glu Ala Ser Ser Glu Ser Ser Gly His Lys Arg Ser Ser Ser
465                 470                 475                 480 
Trp Gly Arg Thr Tyr Ser Phe Thr Ser Ala Met Ser Arg Gly Cys Val
                485                 490                 495     
Thr Glu Glu Glu Asn Thr Asn Val Lys Ala Gly Val Gln Ala Leu Leu
            500                 505                 510         
Gln Val Phe Leu Thr Asn Ser Ala Asn Ile Phe Leu Leu Glu Pro Cys
        515                 520                 525             
Ala Glu Val Pro Val Leu Leu Lys Glu Gln Val Asp Ala Cys Lys Ala
    530                 535                 540                 
Val Leu Ile Ile Phe Arg Arg Met Ile Met Glu Leu Thr Met Asn Lys
545                 550                 555                 560 
Lys Thr Trp Glu Gln Met Leu Gln Ile Leu Leu Arg Ile Thr Glu Ala
                565                 570                 575     
Val Met Gln Lys Pro Lys Asp Lys Gln Ile Lys Asp Leu Phe Ala Gln
            580                 585                 590         
Ser Leu Ala Gly Leu Leu Phe Arg Thr Leu Met Val Ala Trp Ile Arg
        595                 600                 605             
Ala Asn Leu Cys Val Tyr Ile Ser Arg Glu Leu Trp Asp Asp Phe Leu
    610                 615                 620                 
Gly Val Leu Ser Ser Leu Thr Glu Trp Glu Glu Leu Ile Asn Glu Trp
625                 630                 635                 640 
Ala Asn Ile Met Asp Ser Leu Thr Ala Val Leu Ala Arg Thr Val Tyr
                645                 650                 655     
Gly Val Glu Met Thr Asn Leu Pro Leu Asp Lys Leu Ser Glu Gln Lys
            660                 665                 670         
Glu Lys Lys Gln Arg Gly Lys Gly Cys Val Leu Asp Pro Gln Lys Gly
        675                 680                 685             
Thr Thr Val Gly Arg Ser Phe Ser Leu Ser Trp Arg Ser His Pro Asp
    690                 695                 700                 
Val Thr Glu Pro Met Arg Phe Arg Ser Ala Thr Thr Ser Gly Ala Pro
705                 710                 715                 720 
Gly Val Glu Lys Ala Arg Asn Ile Val Arg Gln Lys Ala Thr Glu Val
                725                 730                 735     
Glu Glu Cys Gln Gln Ser Glu Asn Ala Pro Ala Ala Gly Ser Gly His
            740                 745                 750         
Leu Thr Val Gly Gln Gln Gln Gln Val Leu Arg Ser Ser Ser Thr Ser
        755                 760                 765             
Asp Ile Pro Glu Pro Leu Cys Ser Asp Ser Ser Gln Gly Gln Lys Ala
    770                 775                 780                 
Glu Asn Thr Gln Asn Ser Ser Ser Ser Glu Pro Gln Pro Ile Gln Glu
785                 790                 795                 800 
Asn Lys Gly His Val Lys Arg Glu His Glu Gly Ile Thr Ile Leu Val
                805                 810                 815     
Arg Arg Ser Ser Ser Pro Ala Glu Leu Asp Leu Lys Asp Asp Leu Gln
            820                 825                 830         
Gln Thr Gln Gly Lys Cys Arg Glu Arg Gln Lys Ser Glu Ser Thr Asn
        835                 840                 845             
Ser Asp Thr Thr Leu Gly Cys Thr Asn Glu Ala Glu Leu Ser Met Gly
    850                 855                 860                 
Pro Trp Gln Thr Cys Glu Glu Asp Pro Glu Leu Asn Thr Pro Thr Asp
865                 870                 875                 880 
Val Val Ala Asp Ala Asp Ala Arg His Trp Leu Gln Leu Ser Pro Thr
                885                 890                 895     
Asp Ala Ser Asn Leu Thr Asp Ser Ser Glu Cys Leu Thr Asp Asp Cys
            900                 905                 910         
Ser Ile Ile Ala Gly Gly Ser Leu Thr Gly Trp His Pro Asp Ser Ala
        915                 920                 925             
Ala Val Leu Trp Arg Arg Val Leu Gly Ile Leu Gly Asp Val Asn Asn
    930                 935                 940                 
Ile Gln Ser Pro Lys Ile His Ala Arg Val Phe Cys Tyr Leu Tyr Glu
945                 950                 955                 960 
Leu Trp Tyr Lys Leu Ala Lys Ile Arg Asp Asn Leu Ala Ile Ser Leu
                965                 970                 975     
Asp Asn Gln Ser Ser Pro Ser Pro Pro Val Leu Ile Pro Pro Leu Arg
            980                 985                 990         
Met Phe Ala Ser Trp Leu Phe Lys Ala Ala Thr Leu Pro Asn Glu Tyr
        995                 1000                1005            
Lys Glu Gly Lys Leu Gln Ala Tyr Arg Leu Ile Cys Ala Met Met Thr
    1010                1015                1020                
Arg Arg Gln Asp Val Leu Pro Asn Ser Asp Phe Leu Val His Phe Tyr
1025                1030                1035                1040
Leu Val Met His Leu Gly Leu Thr Ser Glu Asp Gln Asp Ile Leu Asn
                1045                1050                1055    
Thr Ile Ile Arg His Cys Pro Pro Arg Phe Phe Ser Leu Gly Phe Pro
            1060                1065                1070        
Gly Phe Ser Met Leu Val Gly Asp Phe Ile Thr Ala Ala Ala Arg Val
        1075                1080                1085            
Leu Ser Thr Asp Ile Leu Thr Ala Pro Arg Ser Glu Ala Val Thr Val
    1090                1095                1100                
Leu Gly Ser Leu Val Cys Phe Pro Asn Thr Tyr Gln Glu Ile Pro Leu
1105                1110                1115                1120
Leu Gln Ser Val Pro Glu Val Asn Glu Ala Ile Thr Gly Thr Glu Asp
                1125                1130                1135    
Val Lys His Tyr Leu Ile Asn Ile Leu Leu Lys Asn Ala Thr Glu Glu
            1140                1145                1150        
Pro Asn Glu Tyr Ala Arg Cys Ile Ala Val Cys Ser Leu Gly Val Trp
        1155                1160                1165            
Ile Cys Glu Glu Leu Ala Gln Cys Thr Ser His Pro Gln Val Lys Glu
    1170                1175                1180                
Ala Ile Asn Val Ile Gly Val Thr Leu Lys Phe Pro Asn Lys Ile Val
1185                1190                1195                1200
Ala Gln Val Ala Cys Asp Val Leu Gln Leu Leu Val Ser Tyr Trp Glu
                1205                1210                1215    
Lys Leu Gln Met Phe Glu Thr Ser Leu Pro Arg Lys Met Ala Glu Ile
            1220                1225                1230        
Leu Val Ala Thr Val Ala Phe Leu Leu Pro Ser Ala Glu Tyr Ser Ser
        1235                1240                1245            
Val Glu Thr Asp Lys Lys Phe Ile Val Ser Leu Leu Leu Cys Leu Leu
    1250                1255                1260                
Asp Trp Cys Met Ala Leu Pro Val Ser Val Leu Leu His Pro Val Ser
1265                1270                1275                1280
Thr Ala Val Leu Glu Glu Gln His Ser Ala Arg Ala Pro Leu Leu Asp
                1285                1290                1295    
Tyr Ile Tyr Arg Val Leu His Cys Cys Val Cys Gly Ser Ser Thr Tyr
            1300                1305                1310        
Thr Gln Gln Ser His Tyr Ile Leu Thr Leu Ala Asp Leu Ser Ser Thr
        1315                1320                1325            
Asp Tyr Asp Pro Phe Leu Pro Leu Ala Asn Val Lys Ser Ser Glu Pro
    1330                1335                1340                
Val Gln Tyr His Ser Ser Ala Glu Leu Gly Asn Leu Leu Thr Val Glu
1345                1350                1355                1360
Glu Glu Lys Lys Arg Arg Ser Leu Glu Leu Ile Pro Leu Thr Ala Arg
                1365                1370                1375    
Met Val Met Ala His Leu Val Asn His Leu Gly His Tyr Pro Leu Ser
            1380                1385                1390        
Gly Gly Pro Ala Ile Leu His Ser Leu Val Ser Glu Asn His Asp Asn
        1395                1400                1405            
Ala His Val Glu Gly Ser Glu Leu Ser Phe Glu Val Phe Arg Ser Pro
    1410                1415                1420                
Asn Leu Gln Leu Phe Val Phe Asn Asp Ser Thr Leu Ile Ser Tyr Leu
1425                1430                1435                1440
Gln Thr Pro Thr Glu Gly Pro Val Gly Gly Ser Pro Val Gly Ser Leu
                1445                1450                1455    
Ser Asp Val Arg Val Ile Val Arg Asp Ile Ser Gly Lys Tyr Ser Trp
            1460                1465                1470        
Asp Gly Lys Val Leu Tyr Gly Pro Leu Glu Gly Cys Leu Ala Pro Asn
        1475                1480                1485            
Gly Arg Asn Pro Ser Phe Leu Ile Ser Ser Trp His Arg Asp Thr Phe
    1490                1495                1500                
Gly Pro Gln Lys Asp Ser Ser Gln Val Glu Glu Gly Asp Asp Val Leu
1505                1510                1515                1520
Asp Lys Leu Leu Glu Asn Ile Gly His Thr Ser Pro Glu Cys Leu Leu
                1525                1530                1535    
Pro Ser Gln Leu Asn Leu Asn Glu Pro Ser Leu Thr Pro Cys Gly Met
            1540                1545                1550        
Asn Tyr Asp Gln Glu Lys Glu Ile Ile Glu Val Ile Leu Arg Gln Asn
        1555                1560                1565            
Ala Gln Glu Asp Glu Tyr Ile Gln Ser His Asn Phe Asp Ser Ala Met
    1570                1575                1580                
Lys Val Thr Ser Gln Gly Gln Pro Ser Pro Val Glu Pro Arg Gly Pro
1585                1590                1595                1600
Phe Tyr Phe Cys Arg Leu Leu Leu Asp Asp Leu Gly Met Asn Ser Trp
                1605                1610                1615    
Asp Arg Arg Lys Asn Phe His Leu Leu Lys Lys Asn Ser Lys Leu Leu
            1620                1625                1630        
Arg Glu Leu Lys Asn Leu Asp Ser Arg Gln Cys Arg Glu Thr His Lys
        1635                1640                1645            
Ile Ala Val Phe Tyr Ile Ala Glu Gly Gln Glu Asp Lys Cys Ser Ile
    1650                1655                1660                
Leu Ser Asn Glu Arg Gly Ser Gln Ala Tyr Glu Asp Phe Val Ala Gly
1665                1670                1675                1680
Leu Gly Trp Glu Val Asp Leu Ser Thr His Cys Gly Phe Met Gly Gly
                1685                1690                1695    
Leu Gln Arg Asn Gly Ser Thr Gly Gln Thr Ala Pro Tyr Tyr Ala Thr
            1700                1705                1710        
Ser Thr Val Glu Val Ile Phe His Val Ser Thr Arg Met Pro Ser Asp
        1715                1720                1725            
Ser Asp Asp Ser Leu Thr Lys Lys Leu Arg His Leu Gly Asn Asp Glu
    1730                1735                1740                
Val His Ile Val Trp Ser Glu His Ser Arg Asp Tyr Arg Arg Gly Ile
1745                1750                1755                1760
Ile Pro Thr Ala Phe Gly Asp Val Ser Ile Ile Ile Tyr Pro Met Lys
                1765                1770                1775    
Asn His Met Phe Phe Ile Ala Ile Thr Lys Lys Pro Glu Val Pro Phe
            1780                1785                1790        
Phe Gly Pro Leu Phe Asp Gly Ala Ile Val Ser Gly Lys Leu Leu Pro
        1795                1800                1805            
Ser Leu Val Cys Ala Thr Cys Ile Asn Ala Ser Arg Ala Val Lys Cys
    1810                1815                1820                
Leu Ile Pro Leu Tyr Gln Ser Phe Tyr Glu Glu Arg Ala Leu Tyr Leu
1825                1830                1835                1840
Glu Ala Ile Ile Gln Asn His Arg Glu Val Met Thr Phe Glu Asp Phe
                1845                1850                1855    
Ala Ala Gln Val Phe Ser Pro Ser Pro Ser Tyr Ser Leu Ser Gly Thr
            1860                1865                1870        
Gly Ala Leu Ala Ser Ser Leu Ser Ala Asp Leu Glu Glu Pro Leu Ser
        1875                1880                1885            
Glu Glu Glu Thr Glu His Pro Leu Leu Pro Leu Pro Arg Ala Thr Lys
    1890                1895                1900                
Pro Arg Ile Ser Arg Lys Phe Arg Cys Cys Thr Ser Ala Leu Ser Arg
1905                1910                1915                1920
Ser Ser His
            


<210> 8213
<211> 236
<212> PRT
<213> Homo sapiens

<400> 8213
Met Val Val Arg Glu Ala Ser Ala Ala Gln Ala Ser Leu Ser Gln Val
 1               5                  10                  15      
Leu Pro Gln Leu Arg Tyr Leu His Ile Phe Leu Glu Gln Val His Thr
            20                  25                  30          
His Phe Gln Glu Gln Ser Val Gly Glu Arg Gly Ala Ala Ile Gln Leu
        35                  40                  45              
Ala Glu Gly Leu Ala Arg Gln Leu Cys Thr Asp Cys Gln Leu Asn Lys
    50                  55                  60                  
Leu Phe Tyr Arg Glu Glu Phe Val Leu Ala Thr Leu Leu Asp Pro Cys
65                  70                  75                  80  
Phe Lys Gly Lys Ile Glu Ala Ile Leu Pro Trp Gly Pro Thr Asp Ile
                85                  90                  95      
Asp His Trp Lys Gln Val Leu Val Tyr Lys Val Lys Glu Ile Arg Val
            100                 105                 110         
Ser Glu Tyr Ser Leu Asn Ser Pro Ser Pro Leu Gln Ser Pro Arg Gly
        115                 120                 125             
Leu Cys Val Asp Pro Thr Arg Val Ala Lys Ser Ser Gly Val Glu Gly
    130                 135                 140                 
Arg Ser Gln Gly Glu Pro Leu Gln Ser Ser Ser His Ser Gly Ala Phe
145                 150                 155                 160 
Leu Leu Ala Gln Arg Glu Lys Gly Leu Leu Glu Ser Met Gly Leu Leu
                165                 170                 175     
Ala Ser Glu Arg Ser Gly Gly Ser Leu Ser Thr Lys Ser His Trp Ala
            180                 185                 190         
Ser Ile Ile Val Lys Lys Tyr Leu Trp Glu Asn Glu Thr Val Gly Ala
        195                 200                 205             
Gln Asp Asp Pro Leu Ala Tyr Trp Glu Lys Lys Arg Glu Ala Trp Pro
    210                 215                 220                 
Pro Ser Ile Cys Leu Thr Pro His Arg Ser Leu Leu
225                 230                 235     


<210> 8214
<211> 475
<212> PRT
<213> Homo sapiens

<400> 8214
Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly
 1               5                  10                  15      
Arg Leu Glu Ala Val Ser His Thr Ser Asp Met His Arg Gly Tyr Ala
            20                  25                  30          
Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp
        35                  40                  45              
Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu
    50                  55                  60                  
Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Thr Gly Leu
65                  70                  75                  80  
Lys Leu Glu Arg Ala Leu Leu Val Thr Ala Ser Gln Cys Gln Gln Pro
                85                  90                  95      
Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile
            100                 105                 110         
Lys Glu Val Ile Thr Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe
        115                 120                 125             
Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val
    130                 135                 140                 
Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala
145                 150                 155                 160 
Ala Met Phe Tyr Thr Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp
                165                 170                 175     
Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Thr Glu
            180                 185                 190         
Leu Gln Ala Tyr Ile Lys Glu Phe His Thr Thr Gly Leu Ala Trp Ser
        195                 200                 205             
Lys Thr Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro
    210                 215                 220                 
Ser Ala Gly Ser Gly Pro Pro Pro Pro Pro Pro Gly Pro Pro Pro Pro
225                 230                 235                 240 
Pro Val Ser Thr Ser Ser Gly Ser Asp Glu Ser Ala Ser Arg Ser Ala
                245                 250                 255     
Leu Phe Ala Gln Ile Asn Gln Gly Glu Ser Ile Thr His Ala Leu Lys
            260                 265                 270         
His Val Ser Asp Asp Met Lys Thr His Lys Asn Pro Ala Leu Lys Ala
        275                 280                 285             
Gln Ser Gly Pro Val Arg Ser Gly Pro Lys Pro Phe Ser Ala Pro Lys
    290                 295                 300                 
Pro Gln Thr Ser Pro Ser Pro Lys Arg Ala Thr Lys Lys Glu Pro Ala
305                 310                 315                 320 
Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Asn Gln Glu Asn
                325                 330                 335     
Val Ser Asn Leu Val Ile Glu Asp Thr Glu Leu Lys Gln Val Ala Tyr
            340                 345                 350         
Ile Tyr Lys Cys Val Asn Thr Thr Leu Gln Ile Lys Gly Lys Ile Asn
        355                 360                 365             
Ser Ile Thr Val Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asp
    370                 375                 380                 
Val Val Gly Ile Val Glu Ile Ile Asn Ser Lys Asp Val Lys Val Gln
385                 390                 395                 400 
Val Met Gly Lys Val Pro Thr Ile Ser Ile Asn Lys Thr Asp Gly Cys
                405                 410                 415     
His Ala Tyr Leu Ser Lys Asn Ser Leu Asp Cys Glu Ile Val Ser Ala
            420                 425                 430         
Lys Ser Ser Glu Met Asn Val Leu Ile Pro Thr Glu Gly Gly Asp Phe
        435                 440                 445             
Asn Glu Phe Pro Val Pro Glu Gln Phe Lys Thr Leu Trp Asn Gly Gln
    450                 455                 460                 
Lys Leu Val Thr Thr Val Thr Glu Ile Ala Gly
465                 470                 475 


<210> 8215
<211> 1482
<212> PRT
<213> Homo sapiens

<400> 8215
Met Glu Pro Gly Cys Asp Glu Phe Leu Pro Pro Pro Glu Cys Pro Val
 1               5                  10                  15      
Phe Glu Pro Ser Trp Ala Glu Phe Gln Asp Pro Leu Gly Tyr Ile Ala
            20                  25                  30          
Lys Ile Arg Pro Ile Ala Glu Lys Ser Gly Ile Cys Lys Ile Arg Pro
        35                  40                  45              
Pro Ala Asp Trp Gln Pro Pro Phe Ala Val Glu Val Asp Asn Phe Arg
    50                  55                  60                  
Phe Thr Pro Arg Val Gln Arg Leu Asn Glu Leu Glu Ala Gln Thr Arg
65                  70                  75                  80  
Val Lys Leu Asn Tyr Leu Asp Gln Ile Ala Lys Phe Trp Glu Ile Gln
                85                  90                  95      
Gly Ser Ser Leu Lys Ile Pro Asn Val Glu Arg Lys Ile Leu Asp Leu
            100                 105                 110         
Tyr Ser Leu Ser Lys Gln Cys Asn Thr His Pro Phe Asp Asn Glu Val
        115                 120                 125             
Lys Asp Lys Glu Tyr Lys Pro His Ser Ile Pro Leu Arg Gln Ser Val
    130                 135                 140                 
Gln Pro Ser Lys Phe Ser Ser Tyr Ser Arg Arg Ala Lys Arg Leu Gln
145                 150                 155                 160 
Pro Asp Pro Glu Pro Thr Glu Glu Asp Ile Glu Lys His Pro Glu Leu
                165                 170                 175     
Lys Lys Leu Gln Ile Tyr Gly Pro Gly Pro Lys Met Met Gly Leu Gly
            180                 185                 190         
Leu Met Ala Lys Asp Lys Asp Lys Thr Val His Lys Lys Val Thr Cys
        195                 200                 205             
Pro Pro Thr Val Thr Val Lys Asp Glu Gln Ser Gly Gly Gly Asn Val
    210                 215                 220                 
Ser Ser Thr Leu Leu Lys Gln His Leu Ser Leu Glu Pro Cys Thr Lys
225                 230                 235                 240 
Thr Thr Met Gln Leu Arg Lys Asn His Ser Ser Ala Gln Phe Ile Asp
                245                 250                 255     
Ser Tyr Ile Cys Gln Val Cys Ser Arg Gly Asp Glu Asp Asp Lys Leu
            260                 265                 270         
Leu Phe Cys Asp Gly Cys Asp Asp Asn Tyr His Ile Phe Cys Leu Leu
        275                 280                 285             
Pro Pro Leu Pro Glu Ile Pro Arg Gly Ile Trp Arg Cys Pro Lys Cys
    290                 295                 300                 
Ile Leu Ala Glu Cys Lys Gln Pro Pro Glu Ala Phe Gly Phe Glu Gln
305                 310                 315                 320 
Ala Thr Gln Glu Tyr Ser Leu Gln Ser Phe Gly Glu Met Ala Asp Ser
                325                 330                 335     
Phe Lys Ser Asp Tyr Phe Asn Met Pro Val His Met Val Pro Thr Glu
            340                 345                 350         
Leu Val Glu Lys Glu Phe Trp Arg Leu Val Ser Ser Ile Glu Glu Asp
        355                 360                 365             
Val Thr Val Glu Tyr Gly Ala Asp Ile His Ser Lys Glu Phe Gly Ser
    370                 375                 380                 
Gly Phe Pro Val Ser Asn Ser Lys Gln Asn Leu Ser Pro Glu Glu Lys
385                 390                 395                 400 
Glu Tyr Ala Thr Ser Gly Trp Asn Leu Asn Val Met Pro Val Leu Asp
                405                 410                 415     
Gln Ser Val Leu Cys His Ile Asn Ala Asp Ile Ser Gly Met Lys Val
            420                 425                 430         
Pro Trp Leu Tyr Val Gly Met Val Phe Ser Ala Phe Cys Trp His Ile
        435                 440                 445             
Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu His Trp Gly Glu Pro
    450                 455                 460                 
Lys Thr Trp Tyr Gly Val Pro Ser Leu Ala Ala Glu His Leu Glu Glu
465                 470                 475                 480 
Val Met Lys Met Leu Thr Pro Glu Leu Phe Asp Ser Gln Pro Asp Leu
                485                 490                 495     
Leu His Gln Leu Val Thr Leu Met Asn Pro Asn Thr Leu Met Ser His
            500                 505                 510         
Gly Val Pro Val Val Arg Thr Asn Gln Cys Ala Gly Glu Phe Val Ile
        515                 520                 525             
Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn Gln Gly Tyr Asn Phe
    530                 535                 540                 
Ala Glu Ala Val Asn Phe Cys Thr Ala Asp Trp Leu Pro Ala Gly Arg
545                 550                 555                 560 
Gln Cys Ile Glu His Tyr Arg Arg Leu Arg Arg Tyr Cys Val Phe Ser
                565                 570                 575     
His Glu Glu Leu Ile Cys Lys Met Ala Ala Phe Pro Glu Thr Leu Asp
            580                 585                 590         
Leu Asn Leu Ala Val Ala Val His Lys Glu Met Phe Ile Met Val Gln
        595                 600                 605             
Glu Glu Arg Arg Leu Arg Lys Ala Leu Leu Glu Lys Gly Val Thr Glu
    610                 615                 620                 
Ala Glu Arg Glu Ala Phe Glu Leu Leu Pro Asp Asp Glu Arg Gln Cys
625                 630                 635                 640 
Ile Lys Cys Lys Thr Thr Cys Phe Leu Ser Ala Leu Ala Cys Tyr Asp
                645                 650                 655     
Cys Pro Asp Gly Leu Val Cys Leu Ser His Ile Asn Asp Leu Cys Lys
            660                 665                 670         
Cys Ser Ser Ser Arg Gln Tyr Leu Arg Tyr Arg Tyr Thr Leu Asp Glu
        675                 680                 685             
Leu Pro Thr Met Leu His Lys Leu Lys Ile Arg Ala Glu Ser Phe Asp
    690                 695                 700                 
Thr Trp Ala Asn Lys Val Arg Val Ala Leu Glu Val Glu Asp Gly Arg
705                 710                 715                 720 
Lys Arg Ser Phe Glu Glu Leu Arg Ala Leu Glu Ser Glu Ala Arg Glu
                725                 730                 735     
Arg Arg Phe Pro Asn Ser Glu Leu Leu Gln Arg Leu Lys Asn Cys Leu
            740                 745                 750         
Ser Glu Val Glu Ala Cys Ile Ala Gln Val Leu Gly Leu Val Ser Gly
        755                 760                 765             
Gln Val Ala Arg Met Asp Thr Pro Gln Leu Thr Leu Thr Glu Leu Arg
    770                 775                 780                 
Val Leu Leu Glu Gln Met Gly Ser Leu Pro Cys Ala Met His Gln Ile
785                 790                 795                 800 
Gly Asp Val Lys Asp Val Leu Glu Gln Val Glu Ala Tyr Gln Ala Glu
                805                 810                 815     
Ala Arg Glu Ala Leu Ala Thr Leu Pro Ser Ser Pro Gly Leu Leu Arg
            820                 825                 830         
Ser Leu Leu Glu Arg Gly Gln Gln Leu Gly Val Glu Val Pro Glu Ala
        835                 840                 845             
His Gln Leu Gln Gln Gln Val Glu Gln Ala Gln Trp Leu Asp Glu Val
    850                 855                 860                 
Lys Gln Ala Leu Ala Pro Ser Ala His Arg Gly Ser Leu Val Ile Met
865                 870                 875                 880 
Gln Gly Leu Leu Val Met Gly Ala Lys Ile Ala Ser Ser Pro Ser Val
                885                 890                 895     
Asp Lys Ala Arg Ala Glu Leu Gln Glu Leu Leu Thr Ile Ala Glu Arg
            900                 905                 910         
Trp Glu Glu Lys Ala His Phe Cys Leu Glu Ala Arg Gln Lys His Pro
        915                 920                 925             
Pro Ala Thr Leu Glu Ala Ile Ile Arg Glu Thr Glu Asn Ile Pro Val
    930                 935                 940                 
His Leu Pro Asn Ile Gln Ala Leu Lys Glu Ala Leu Thr Lys Ala Gln
945                 950                 955                 960 
Ala Trp Ile Ala Asp Val Asp Glu Ile Gln Asn Gly Asp His Tyr Pro
                965                 970                 975     
Cys Leu Asp Asp Leu Glu Gly Leu Val Ala Val Gly Arg Asp Leu Pro
            980                 985                 990         
Val Gly Leu Glu Glu Leu Arg Gln Leu Glu Leu Gln Val Leu Thr Ala
        995                 1000                1005            
His Ser Trp Arg Glu Lys Ala Ser Lys Thr Phe Leu Lys Lys Asn Ser
    1010                1015                1020                
Cys Tyr Thr Leu Leu Glu Val Leu Cys Pro Cys Ala Asp Ala Gly Ser
1025                1030                1035                1040
Asp Ser Thr Lys Arg Ser Arg Trp Met Glu Lys Ala Leu Gly Leu Tyr
                1045                1050                1055    
Gln Cys Asp Thr Glu Leu Leu Gly Leu Ser Ala Gln Asp Leu Arg Asp
            1060                1065                1070        
Pro Gly Ser Val Ile Val Ala Phe Lys Glu Gly Glu Gln Lys Glu Lys
        1075                1080                1085            
Glu Gly Ile Leu Gln Leu Arg Arg Thr Asn Ser Ala Lys Pro Ser Pro
    1090                1095                1100                
Leu Ala Pro Ser Leu Met Ala Ser Ser Pro Thr Ser Ile Cys Val Cys
1105                1110                1115                1120
Gly Gln Val Pro Ala Gly Val Gly Val Leu Gln Cys Asp Leu Cys Gln
                1125                1130                1135    
Asp Trp Phe His Gly Gln Cys Val Ser Val Pro His Leu Leu Thr Ser
            1140                1145                1150        
Pro Lys Pro Ser Leu Thr Ser Ser Pro Leu Leu Ala Trp Trp Glu Trp
        1155                1160                1165            
Asp Thr Lys Phe Leu Cys Pro Leu Cys Met Arg Ser Arg Arg Pro Arg
    1170                1175                1180                
Leu Glu Thr Ile Leu Ala Leu Leu Val Ala Leu Gln Arg Leu Pro Val
1185                1190                1195                1200
Arg Leu Pro Glu Gly Glu Ala Leu Gln Cys Leu Thr Glu Arg Ala Ile
                1205                1210                1215    
Gly Trp Gln Asp Arg Ala Arg Lys Ala Leu Ala Ser Glu Asp Val Thr
            1220                1225                1230        
Ala Leu Leu Arg Gln Leu Ala Glu Leu Arg Gln Gln Leu Gln Ala Lys
        1235                1240                1245            
Pro Arg Pro Glu Glu Ala Ser Val Tyr Thr Ser Ala Thr Ala Cys Asp
    1250                1255                1260                
Pro Ile Arg Glu Gly Ser Gly Asn Asn Ile Ser Lys Val Gln Gly Leu
1265                1270                1275                1280
Leu Glu Asn Gly Asp Ser Val Thr Ser Pro Glu Asn Met Ala Pro Gly
                1285                1290                1295    
Lys Gly Ser Asp Leu Glu Leu Leu Ser Ser Leu Leu Pro Gln Leu Thr
            1300                1305                1310        
Gly Pro Val Leu Glu Leu Pro Glu Ala Ile Arg Ala Pro Leu Glu Glu
        1315                1320                1325            
Leu Met Met Glu Gly Asp Leu Leu Glu Val Thr Leu Asp Glu Asn His
    1330                1335                1340                
Ser Ile Trp Gln Leu Leu Gln Ala Gly Gln Pro Pro Asp Leu Asp Arg
1345                1350                1355                1360
Ile Arg Thr Leu Leu Glu Leu Glu Lys Phe Glu His Gln Gly Ser Arg
                1365                1370                1375    
Thr Arg Ser Arg Ala Leu Glu Arg Arg Arg Arg Arg Gln Lys Val Asp
            1380                1385                1390        
Gln Gly Arg Asn Val Glu Asn Leu Val Gln Gln Glu Leu Gln Ser Lys
        1395                1400                1405            
Arg Ala Arg Ser Ser Gly Ile Met Ser Gln Val Gly Arg Glu Glu Glu
    1410                1415                1420                
His Tyr Gln Glu Lys Ala Asp Arg Glu Asn Met Phe Leu Thr Pro Ser
1425                1430                1435                1440
Thr Asp His Ser Pro Phe Leu Lys Gly Asn Gln Asn Ser Leu Gln His
                1445                1450                1455    
Lys Asp Ser Gly Ser Ser Ala Ala Cys Pro Ser Leu Met Pro Leu Leu
            1460                1465                1470        
Gln Leu Ser Tyr Ser Asp Glu Gln Gln Leu
        1475                1480        


<210> 8216
<211> 1539
<212> PRT
<213> Homo sapiens

<400> 8216
Met Glu Pro Gly Cys Asp Glu Phe Leu Pro Pro Pro Glu Cys Pro Val
 1               5                  10                  15      
Phe Glu Pro Ser Trp Ala Glu Phe Gln Asp Pro Leu Gly Tyr Ile Ala
            20                  25                  30          
Lys Ile Arg Pro Ile Ala Glu Lys Ser Gly Ile Cys Lys Ile Arg Pro
        35                  40                  45              
Pro Ala Asp Trp Gln Pro Pro Phe Ala Val Glu Val Asp Asn Phe Arg
    50                  55                  60                  
Phe Thr Pro Arg Val Gln Arg Leu Asn Glu Leu Glu Ala Gln Thr Arg
65                  70                  75                  80  
Val Lys Leu Asn Tyr Leu Asp Gln Ile Ala Lys Phe Trp Glu Ile Gln
                85                  90                  95      
Gly Ser Ser Leu Lys Ile Pro Asn Val Glu Arg Lys Ile Leu Asp Leu
            100                 105                 110         
Tyr Ser Leu Ser Lys Ile Val Ile Glu Glu Gly Gly Tyr Glu Ala Ile
        115                 120                 125             
Cys Lys Asp Arg Arg Trp Ala Arg Val Ala Gln Arg Leu His Tyr Pro
    130                 135                 140                 
Pro Gly Lys Asn Ile Gly Ser Leu Leu Arg Ser His Tyr Glu Arg Ile
145                 150                 155                 160 
Ile Tyr Pro Tyr Glu Met Phe Gln Ser Gly Ala Asn His Val Gln Cys
                165                 170                 175     
Asn Thr His Pro Phe Asp Asn Glu Val Lys Asp Lys Glu Tyr Lys Pro
            180                 185                 190         
His Ser Ile Pro Leu Arg Gln Ser Val Gln Pro Ser Lys Phe Ser Ser
        195                 200                 205             
Tyr Ser Arg Arg Ala Lys Arg Leu Gln Pro Asp Pro Glu Pro Thr Glu
    210                 215                 220                 
Glu Asp Ile Glu Lys His Pro Glu Leu Lys Lys Leu Gln Ile Tyr Gly
225                 230                 235                 240 
Pro Gly Pro Lys Met Met Gly Leu Gly Leu Met Ala Lys Asp Lys Asp
                245                 250                 255     
Lys Thr Val His Lys Lys Val Thr Cys Pro Pro Thr Val Thr Val Lys
            260                 265                 270         
Asp Glu Gln Ser Gly Gly Gly Asn Val Ser Ser Thr Leu Leu Lys Gln
        275                 280                 285             
His Leu Ser Leu Glu Pro Cys Thr Lys Thr Thr Met Gln Leu Arg Lys
    290                 295                 300                 
Asn His Ser Ser Ala Gln Phe Ile Asp Ser Tyr Ile Cys Gln Val Cys
305                 310                 315                 320 
Ser Arg Gly Asp Glu Asp Asp Lys Leu Leu Phe Cys Asp Gly Cys Asp
                325                 330                 335     
Asp Asn Tyr His Ile Phe Cys Leu Leu Pro Pro Leu Pro Glu Ile Pro
            340                 345                 350         
Arg Gly Ile Trp Arg Cys Pro Lys Cys Ile Leu Ala Glu Cys Lys Gln
        355                 360                 365             
Pro Pro Glu Ala Phe Gly Phe Glu Gln Ala Thr Gln Glu Tyr Ser Leu
    370                 375                 380                 
Gln Ser Phe Gly Glu Met Ala Asp Ser Phe Lys Ser Asp Tyr Phe Asn
385                 390                 395                 400 
Met Pro Val His Met Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp
                405                 410                 415     
Arg Leu Val Ser Ser Ile Glu Glu Asp Val Thr Val Glu Tyr Gly Ala
            420                 425                 430         
Asp Ile His Ser Lys Glu Phe Gly Ser Gly Phe Pro Val Ser Asn Ser
        435                 440                 445             
Lys Gln Asn Leu Ser Pro Glu Glu Lys Glu Tyr Ala Thr Ser Gly Trp
    450                 455                 460                 
Asn Leu Asn Val Met Pro Val Leu Asp Gln Ser Val Leu Cys His Ile
465                 470                 475                 480 
Asn Ala Asp Ile Ser Gly Met Lys Val Pro Trp Leu Tyr Val Gly Met
                485                 490                 495     
Val Phe Ser Ala Phe Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser
            500                 505                 510         
Ile Asn Tyr Leu His Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro
        515                 520                 525             
Ser Leu Ala Ala Glu His Leu Glu Glu Val Met Lys Met Leu Thr Pro
    530                 535                 540                 
Glu Leu Phe Asp Ser Gln Pro Asp Leu Leu His Gln Leu Val Thr Leu
545                 550                 555                 560 
Met Asn Pro Asn Thr Leu Met Ser His Gly Val Pro Val Val Arg Thr
                565                 570                 575     
Asn Gln Cys Ala Gly Glu Phe Val Ile Thr Phe Pro Arg Ala Tyr His
            580                 585                 590         
Ser Gly Phe Asn Gln Gly Tyr Asn Phe Ala Glu Ala Val Asn Phe Cys
        595                 600                 605             
Thr Ala Asp Trp Leu Pro Ala Gly Arg Gln Cys Ile Glu His Tyr Arg
    610                 615                 620                 
Arg Leu Arg Arg Tyr Cys Val Phe Ser His Glu Glu Leu Ile Cys Lys
625                 630                 635                 640 
Met Ala Ala Phe Pro Glu Thr Leu Asp Leu Asn Leu Ala Val Ala Val
                645                 650                 655     
His Lys Glu Met Phe Ile Met Val Gln Glu Glu Arg Arg Leu Arg Lys
            660                 665                 670         
Ala Leu Leu Glu Lys Gly Val Thr Glu Ala Glu Arg Glu Ala Phe Glu
        675                 680                 685             
Leu Leu Pro Asp Asp Glu Arg Gln Cys Ile Lys Cys Lys Thr Thr Cys
    690                 695                 700                 
Phe Leu Ser Ala Leu Ala Cys Tyr Asp Cys Pro Asp Gly Leu Val Cys
705                 710                 715                 720 
Leu Ser His Ile Asn Asp Leu Cys Lys Cys Ser Ser Ser Arg Gln Tyr
                725                 730                 735     
Leu Arg Tyr Arg Tyr Thr Leu Asp Glu Leu Pro Thr Met Leu His Lys
            740                 745                 750         
Leu Lys Ile Arg Ala Glu Ser Phe Asp Thr Trp Ala Asn Lys Val Arg
        755                 760                 765             
Val Ala Leu Glu Val Glu Asp Gly Arg Lys Arg Ser Phe Glu Glu Leu
    770                 775                 780                 
Arg Ala Leu Glu Ser Glu Ala Arg Glu Arg Arg Phe Pro Asn Ser Glu
785                 790                 795                 800 
Leu Leu Gln Arg Leu Lys Asn Cys Leu Ser Glu Val Glu Ala Cys Ile
                805                 810                 815     
Ala Gln Val Leu Gly Leu Val Ser Gly Gln Val Ala Arg Met Asp Thr
            820                 825                 830         
Pro Gln Leu Thr Leu Thr Glu Leu Arg Val Leu Leu Glu Gln Met Gly
        835                 840                 845             
Ser Leu Pro Cys Ala Met His Gln Ile Gly Asp Val Lys Asp Val Leu
    850                 855                 860                 
Glu Gln Val Glu Ala Tyr Gln Ala Glu Ala Arg Glu Ala Leu Ala Thr
865                 870                 875                 880 
Leu Pro Ser Ser Pro Gly Leu Leu Arg Ser Leu Leu Glu Arg Gly Gln
                885                 890                 895     
Gln Leu Gly Val Glu Val Pro Glu Ala His Gln Leu Gln Gln Gln Val
            900                 905                 910         
Glu Gln Ala Gln Trp Leu Asp Glu Val Lys Gln Ala Leu Ala Pro Ser
        915                 920                 925             
Ala His Arg Gly Ser Leu Val Ile Met Gln Gly Leu Leu Val Met Gly
    930                 935                 940                 
Ala Lys Ile Ala Ser Ser Pro Ser Val Asp Lys Ala Arg Ala Glu Leu
945                 950                 955                 960 
Gln Glu Leu Leu Thr Ile Ala Glu Arg Trp Glu Glu Lys Ala His Phe
                965                 970                 975     
Cys Leu Glu Ala Arg Gln Lys His Pro Pro Ala Thr Leu Glu Ala Ile
            980                 985                 990         
Ile Arg Glu Thr Glu Asn Ile Pro Val His Leu Pro Asn Ile Gln Ala
        995                 1000                1005            
Leu Lys Glu Ala Leu Thr Lys Ala Gln Ala Trp Ile Ala Asp Val Asp
    1010                1015                1020                
Glu Ile Gln Asn Gly Asp His Tyr Pro Cys Leu Asp Asp Leu Glu Gly
1025                1030                1035                1040
Leu Val Ala Val Gly Arg Asp Leu Pro Val Gly Leu Glu Glu Leu Arg
                1045                1050                1055    
Gln Leu Glu Leu Gln Val Leu Thr Ala His Ser Trp Arg Glu Lys Ala
            1060                1065                1070        
Ser Lys Thr Phe Leu Lys Lys Asn Ser Cys Tyr Thr Leu Leu Glu Val
        1075                1080                1085            
Leu Cys Pro Cys Ala Asp Ala Gly Ser Asp Ser Thr Lys Arg Ser Arg
    1090                1095                1100                
Trp Met Glu Lys Ala Leu Gly Leu Tyr Gln Cys Asp Thr Glu Leu Leu
1105                1110                1115                1120
Gly Leu Ser Ala Gln Asp Leu Arg Asp Pro Gly Ser Val Ile Val Ala
                1125                1130                1135    
Phe Lys Glu Gly Glu Gln Lys Glu Lys Glu Gly Ile Leu Gln Leu Arg
            1140                1145                1150        
Arg Thr Asn Ser Ala Lys Pro Ser Pro Leu Ala Pro Ser Leu Met Ala
        1155                1160                1165            
Ser Ser Pro Thr Ser Ile Cys Val Cys Gly Gln Val Pro Ala Gly Val
    1170                1175                1180                
Gly Val Leu Gln Cys Asp Leu Cys Gln Asp Trp Phe His Gly Gln Cys
1185                1190                1195                1200
Val Ser Val Pro His Leu Leu Thr Ser Pro Lys Pro Ser Leu Thr Ser
                1205                1210                1215    
Ser Pro Leu Leu Ala Trp Trp Glu Trp Asp Thr Lys Phe Leu Cys Pro
            1220                1225                1230        
Leu Cys Met Arg Ser Arg Arg Pro Arg Leu Glu Thr Ile Leu Ala Leu
        1235                1240                1245            
Leu Val Ala Leu Gln Arg Leu Pro Val Arg Leu Pro Glu Gly Glu Ala
    1250                1255                1260                
Leu Gln Cys Leu Thr Glu Arg Ala Ile Gly Trp Gln Asp Arg Ala Arg
1265                1270                1275                1280
Lys Ala Leu Ala Ser Glu Asp Val Thr Ala Leu Leu Arg Gln Leu Ala
                1285                1290                1295    
Glu Leu Arg Gln Gln Leu Gln Ala Lys Pro Arg Pro Glu Glu Ala Ser
            1300                1305                1310        
Val Tyr Thr Ser Ala Thr Ala Cys Asp Pro Ile Arg Glu Gly Ser Gly
        1315                1320                1325            
Asn Asn Ile Ser Lys Val Gln Gly Leu Leu Glu Asn Gly Asp Ser Val
    1330                1335                1340                
Thr Ser Pro Glu Asn Met Ala Pro Gly Lys Gly Ser Asp Leu Glu Leu
1345                1350                1355                1360
Leu Ser Ser Leu Leu Pro Gln Leu Thr Gly Pro Val Leu Glu Leu Pro
                1365                1370                1375    
Glu Ala Ile Arg Ala Pro Leu Glu Glu Leu Met Met Glu Gly Asp Leu
            1380                1385                1390        
Leu Glu Val Thr Leu Asp Glu Asn His Ser Ile Trp Gln Leu Leu Gln
        1395                1400                1405            
Ala Gly Gln Pro Pro Asp Leu Asp Arg Ile Arg Thr Leu Leu Glu Leu
    1410                1415                1420                
Glu Lys Phe Glu His Gln Gly Ser Arg Thr Arg Ser Arg Ala Leu Glu
1425                1430                1435                1440
Arg Arg Arg Arg Arg Gln Lys Val Asp Gln Gly Arg Asn Val Glu Asn
                1445                1450                1455    
Leu Val Gln Gln Glu Leu Gln Ser Lys Arg Ala Arg Ser Ser Gly Ile
            1460                1465                1470        
Met Ser Gln Val Gly Arg Glu Glu Glu His Tyr Gln Glu Lys Ala Asp
        1475                1480                1485            
Arg Glu Asn Met Phe Leu Thr Pro Ser Thr Asp His Ser Pro Phe Leu
    1490                1495                1500                
Lys Gly Asn Gln Asn Ser Leu Gln His Lys Asp Ser Gly Ser Ser Ala
1505                1510                1515                1520
Ala Cys Pro Ser Leu Met Pro Leu Leu Gln Leu Ser Tyr Ser Asp Glu
                1525                1530                1535    
Gln Gln Leu
            


<210> 8217
<211> 261
<212> PRT
<213> Homo sapiens

<400> 8217
Met Asp Arg Phe Leu Val Lys Gly Ala Gln Gly Gly Leu Leu Arg Lys
 1               5                  10                  15      
Gln Glu Glu Gln Glu Pro Thr Gly Glu Glu Pro Ala Val Leu Gly Gly
            20                  25                  30          
Asp Lys Glu Ser Thr Arg Lys Arg Pro Arg Arg Glu Ala Pro Gly Asn
        35                  40                  45              
Gly Gly His Ser Ala Gly Pro Ser Trp Arg His Ile Arg Ala Glu Gly
    50                  55                  60                  
Leu Asp Cys Ser Tyr Thr Val Leu Phe Gly Lys Ala Glu Ala Asp Glu
65                  70                  75                  80  
Ile Phe Gln Glu Leu Glu Lys Glu Val Glu Tyr Phe Thr Gly Ala Leu
                85                  90                  95      
Ala Arg Val Gln Val Phe Gly Lys Trp His Ser Val Pro Arg Lys Gln
            100                 105                 110         
Ala Thr Tyr Gly Asp Ala Gly Leu Thr Tyr Thr Phe Ser Gly Leu Thr
        115                 120                 125             
Leu Ser Pro Lys Pro Trp Ile Pro Val Leu Glu Arg Ile Arg Asp His
    130                 135                 140                 
Val Ser Gly Val Thr Gly Gln Thr Phe Asn Phe Val Leu Ile Asn Arg
145                 150                 155                 160 
Tyr Lys Asp Gly Cys Asp His Ile Gly Glu His Arg Asp Asp Glu Arg
                165                 170                 175     
Glu Leu Ala Pro Gly Ser Pro Ile Ala Ser Val Ser Phe Gly Ala Cys
            180                 185                 190         
Arg Asp Phe Val Phe Arg His Lys Asp Ser Arg Gly Lys Ser Pro Ser
        195                 200                 205             
Arg Arg Val Ala Val Val Arg Leu Pro Leu Ala His Gly Ser Leu Leu
    210                 215                 220                 
Met Met Asn His Pro Thr Asn Thr His Trp Tyr His Ser Leu Pro Val
225                 230                 235                 240 
Arg Lys Lys Val Leu Ala Pro Arg Val Asn Leu Thr Phe Arg Lys Ile
                245                 250                 255     
Leu Leu Thr Lys Lys
            260     


<210> 8218
<211> 664
<212> PRT
<213> Homo sapiens

<400> 8218
Met Val Ser Val Glu Gly Arg Ala Met Ser Phe Gln Ser Ile Ile His
 1               5                  10                  15      
Leu Ser Leu Asp Ser Pro Val His Ala Val Cys Val Leu Gly Thr Glu
            20                  25                  30          
Ile Cys Leu Asp Leu Ser Gly Cys Ala Pro Gln Lys Cys Gln Cys Phe
        35                  40                  45              
Thr Ile His Gly Ser Gly Arg Val Leu Ile Asp Val Ala Asn Thr Val
    50                  55                  60                  
Ile Ser Glu Lys Glu Asp Ala Thr Ile Trp Trp Pro Leu Ser Asp Pro
65                  70                  75                  80  
Thr Tyr Ala Thr Val Lys Met Thr Ser Pro Ser Pro Ser Val Asp Ala
                85                  90                  95      
Asp Lys Val Ser Val Thr Tyr Tyr Gly Pro Asn Glu Asp Ala Pro Val
            100                 105                 110         
Gly Thr Ala Val Leu Tyr Leu Thr Gly Ile Glu Val Ser Leu Glu Val
        115                 120                 125             
Asp Ile Tyr Arg Asn Gly Gln Val Glu Met Ser Ser Asp Lys Gln Ala
    130                 135                 140                 
Lys Pro Asn Cys Cys Asp Ile Ala Glu Gly Leu Asp Thr Trp Arg Gly
145                 150                 155                 160 
Gly Lys Lys Trp Ile Trp Gly Pro Ser Gly Trp Gly Ala Ile Leu Leu
                165                 170                 175     
Val Asn Cys Asn Pro Ala Asp Val Gly Gln Gln Leu Glu Asp Lys Lys
            180                 185                 190         
Thr Lys Lys Val Ile Phe Ser Glu Glu Ile Thr Asn Leu Ser Gln Met
        195                 200                 205             
Thr Leu Asn Val Gln Gly Pro Ser Cys Ile Leu Lys Lys Tyr Arg Leu
    210                 215                 220                 
Val Leu His Thr Ser Lys Glu Glu Ser Lys Lys Ala Arg Val Tyr Trp
225                 230                 235                 240 
Pro Gln Lys Asp Asn Ser Ser Thr Phe Glu Leu Val Leu Gly Pro Asp
                245                 250                 255     
Gln His Ala Tyr Thr Leu Ala Leu Leu Gly Asn His Leu Lys Glu Thr
            260                 265                 270         
Phe Tyr Val Glu Ala Ile Ala Phe Pro Ser Ala Glu Phe Ser Gly Leu
        275                 280                 285             
Ile Ser Tyr Ser Val Ser Leu Val Glu Glu Ser Gln Asp Pro Ser Ile
    290                 295                 300                 
Pro Glu Thr Val Leu Tyr Lys Asp Thr Val Val Phe Arg Val Ala Pro
305                 310                 315                 320 
Cys Val Phe Ile Pro Cys Thr Gln Asp Glu Met Ala Phe Cys Tyr Thr
                325                 330                 335     
Gln Ala Pro His Lys Thr Thr Ser Leu Ile Leu Asp Thr Pro Gln Ala
            340                 345                 350         
Ala Asp Leu Asp Glu Phe Pro Met Lys Tyr Ser Leu Ser Pro Gly Ile
        355                 360                 365             
Gly Tyr Met Ile Gln Asp Thr Glu Asp His Lys Val Ala Ser Met Asp
    370                 375                 380                 
Ser Ile Gly Asn Leu Met Val Ser Pro Pro Val Lys Val Gln Gly Lys
385                 390                 395                 400 
Glu Tyr Pro Leu Gly Arg Val Leu Ile Gly Ser Ser Phe Tyr Pro Ser
                405                 410                 415     
Ala Glu Gly Arg Ala Met Ser Lys Thr Leu Arg Asp Phe Leu Tyr Ala
            420                 425                 430         
Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser Asp Trp Leu Met Thr
        435                 440                 445             
Gly His Val Asp Glu Phe Met Cys Phe Ile Pro Thr Asp Asp Lys Asn
    450                 455                 460                 
Glu Gly Lys Lys Gly Phe Leu Leu Leu Leu Ala Ser Pro Ser Ala Cys
465                 470                 475                 480 
Tyr Lys Leu Phe Arg Glu Lys Gln Lys Glu Gly Tyr Gly Asp Ala Leu
                485                 490                 495     
Leu Phe Asp Glu Leu Arg Ala Asp Gln Leu Leu Ser Asn Gly Arg Glu
            500                 505                 510         
Ala Lys Thr Ile Asp Gln Leu Leu Ala Asp Glu Ser Leu Lys Lys Gln
        515                 520                 525             
Asn Glu Tyr Val Glu Lys Cys Ile His Leu Asn Arg Asp Ile Leu Lys
    530                 535                 540                 
Thr Glu Leu Gly Leu Val Glu Gln Asp Ile Ile Glu Ile Pro Gln Leu
545                 550                 555                 560 
Phe Cys Leu Glu Lys Leu Thr Asn Ile Pro Ser Asp Gln Gln Pro Lys
                565                 570                 575     
Arg Ser Phe Ala Arg Pro Tyr Phe Pro Asp Leu Leu Arg Met Ile Val
            580                 585                 590         
Met Gly Lys Asn Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Ile Lys
        595                 600                 605             
Gly Thr Cys Cys Leu Glu Glu Lys Ile Cys Cys Leu Leu Glu Pro Leu
    610                 615                 620                 
Gly Phe Lys Cys Thr Phe Ile Asn Asp Phe Asp Cys Tyr Leu Thr Glu
625                 630                 635                 640 
Val Gly Asp Ile Cys Ala Cys Ala Asn Ile Arg Arg Val Pro Phe Ala
                645                 650                 655     
Phe Lys Trp Trp Lys Met Val Pro
            660                 


<210> 8219
<211> 1249
<212> PRT
<213> Homo sapiens

<400> 8219
Met Gly Lys Asp Gln Glu Leu Leu Glu Ala Ala Arg Thr Gly Asn Val
 1               5                  10                  15      
Ala Leu Val Glu Lys Leu Leu Ser Gly Arg Lys Gly Gly Ile Leu Gly
            20                  25                  30          
Gly Gly Ser Gly Pro Leu Pro Leu Ser Asn Leu Leu Ser Ile Trp Arg
        35                  40                  45              
Gly Pro Asn Val Asn Cys Thr Asp Ser Ser Gly Tyr Thr Ala Leu His
    50                  55                  60                  
His Ala Ala Leu Asn Gly His Lys Asp Ile Val Leu Lys Leu Leu Gln
65                  70                  75                  80  
Tyr Glu Ala Ser Thr Asn Val Ala Asp Asn Lys Gly Tyr Phe Pro Ile
                85                  90                  95      
His Leu Ala Ala Trp Lys Gly Asp Val Glu Ile Val Lys Ile Leu Ile
            100                 105                 110         
His His Gly Pro Ser His Ser Arg Val Asn Glu Gln Asn Asn Glu Asn
        115                 120                 125             
Glu Thr Ala Leu His Cys Ala Ala Gln Tyr Gly His Ser Glu Val Val
    130                 135                 140                 
Ala Val Leu Leu Glu Glu Leu Thr Asp Pro Thr Ile Arg Asn Ser Lys
145                 150                 155                 160 
Leu Glu Thr Pro Leu Asp Leu Ala Ala Leu Tyr Gly Arg Leu Arg Val
                165                 170                 175     
Val Lys Met Ile Ile Ser Ala His Pro Asn Leu Met Ser Cys Asn Thr
            180                 185                 190         
Arg Lys His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Lys Ala
        195                 200                 205             
Val Val Gln Val Leu Leu Glu Ala Gly Met Asp Val Ser Cys Gln Thr
    210                 215                 220                 
Glu Lys Gly Ser Ala Leu His Glu Ala Ala Leu Phe Gly Lys Val Asp
225                 230                 235                 240 
Val Val Arg Val Leu Leu Glu Thr Gly Ile Asp Ala Asn Ile Lys Asp
                245                 250                 255     
Ser Leu Gly Arg Thr Val Leu Asp Ile Leu Lys Glu His Pro Ser Gln
            260                 265                 270         
Lys Ser Leu Gln Ile Ala Thr Leu Leu Gln Glu Tyr Leu Glu Gly Val
        275                 280                 285             
Gly Lys Tyr Ala Thr Val Leu Glu Glu Pro Val Gln Glu Asp Ala Thr
    290                 295                 300                 
Gln Glu Thr His Ile Ser Ser Pro Val Glu Ser Pro Ser Gln Lys Thr
305                 310                 315                 320 
Lys Ser Glu Thr Val Thr Gly Glu Leu Ser Lys Leu Leu Asp Glu Ile
                325                 330                 335     
Lys Leu Cys Gln Glu Lys Asp Tyr Ser Phe Glu Asp Leu Cys His Thr
            340                 345                 350         
Ile Ser Asp His Tyr Leu Asp Asn Leu Ser Lys Ile Ser Glu Glu Glu
        355                 360                 365             
Leu Gly Lys Asn Gly Ser Gln Ser Val Arg Thr Ser Ser Thr Ile Asn
    370                 375                 380                 
Leu Ser Pro Gly Glu Val Glu Glu Glu Asp Asp Asp Glu Asn Thr Cys
385                 390                 395                 400 
Gly Pro Ser Gly Leu Trp Glu Ala Leu Thr Pro Cys Asn Gly Cys Arg
                405                 410                 415     
Asn Leu Gly Phe Pro Met Leu Ala Gln Glu Ser Tyr Pro Lys Lys Arg
            420                 425                 430         
Asn Tyr Thr Met Glu Ile Val Pro Ser Ala Ser Leu Asp Thr Phe Pro
        435                 440                 445             
Ser Glu Asn Glu Asn Phe Leu Cys Asp Leu Met Asp Thr Ala Val Thr
    450                 455                 460                 
Lys Lys Pro Cys Ser Leu Glu Ile Ala Arg Ala Pro Ser Pro Arg Thr
465                 470                 475                 480 
Asp Asn Ala Ser Glu Val Ala Val Thr Thr Pro Gly Thr Ser Asn His
                485                 490                 495     
Arg Asn Ser Ser Thr Gly Pro Thr Pro Asp Cys Ser Pro Pro Ser Pro
            500                 505                 510         
Asp Thr Ala Leu Lys Asn Ile Val Lys Val Ile Arg Pro Gln Pro Lys
        515                 520                 525             
Gln Arg Thr Ser Ile Val Ser Ser Leu Asp Phe His Arg Met Asn His
    530                 535                 540                 
Asn Gln Glu Tyr Phe Glu Ile Asn Thr Ser Thr Gly Cys Thr Ser Phe
545                 550                 555                 560 
Thr Ala Ser Pro Pro Ala Ser Pro Pro Thr Ser Ser Val Gly Thr Thr
                565                 570                 575     
Glu Val Lys Asn Glu Gly Thr Asn His Thr Asp Asp Leu Ser Arg Gln
            580                 585                 590         
Asp Asp Asn Asp Pro Pro Lys Glu Tyr Asp Pro Gly Gln Phe Ala Gly
        595                 600                 605             
Leu Leu His Gly Ser Ser Pro Ala Cys Glu Ser Pro Glu Asn Pro Phe
    610                 615                 620                 
His Leu Tyr Gly Lys Arg Glu Gln Cys Glu Lys Gly Gln Asp Glu Val
625                 630                 635                 640 
Ser Leu Ala Asn Ser Pro Leu Pro Phe Lys Gln Ser Pro Ile Glu Asn
                645                 650                 655     
Asn Ser Glu Pro Leu Val Lys Lys Ile Lys Pro Lys Val Val Ser Arg
            660                 665                 670         
Thr Ile Phe His Lys Lys Ser Asn Gln Leu Glu Asn His Thr Ile Val
        675                 680                 685             
Gly Thr Arg Ser Thr Arg Ser Gly Ser Arg Asn Gly Asp Gln Trp Val
    690                 695                 700                 
Met Asn Ala Gly Gly Phe Val Glu Arg Ala Cys Thr Leu Gly Arg Ile
705                 710                 715                 720 
Arg Ser Leu Pro Lys Ala Leu Ile Asp Met His Leu Ser Lys Ser Val
                725                 730                 735     
Ser Lys Ser Asp Ser Asp Leu Ile Ala Tyr Pro Ser Asn Glu Lys Thr
            740                 745                 750         
Ser Arg Val Asn Trp Ser Glu Ser Ser Thr Ala Glu His Ser Ser Lys
        755                 760                 765             
Gly Asn Ser Glu Arg Thr Pro Ser Phe Thr Ser Glu Trp Glu Glu Ile
    770                 775                 780                 
Asp Lys Ile Met Ser Ser Ile Asp Val Gly Ile Asn Asn Glu Leu Lys
785                 790                 795                 800 
Glu Met Asn Gly Glu Thr Thr Arg Pro Arg Cys Pro Val Gln Thr Val
                805                 810                 815     
Gly Gln Trp Leu Glu Ser Ile Gly Leu Pro Gln Tyr Glu Asn His Leu
            820                 825                 830         
Met Ala Asn Gly Phe Asp Asn Val Gln Phe Met Gly Ser Asn Val Met
        835                 840                 845             
Glu Asp Gln Asp Leu Leu Glu Ile Gly Ile Leu Asn Ser Gly His Arg
    850                 855                 860                 
Gln Arg Ile Leu Gln Ala Ile Gln Leu Leu Pro Lys Met Arg Pro Ile
865                 870                 875                 880 
Gly His Asp Gly Tyr His Pro Thr Ser Val Ala Glu Trp Leu Asp Ser
                885                 890                 895     
Ile Glu Leu Gly Asp Tyr Thr Lys Ala Phe Leu Ile Asn Gly Tyr Thr
            900                 905                 910         
Ser Met Asp Leu Leu Lys Lys Ile Trp Glu Val Glu Leu Ile Asn Val
        915                 920                 925             
Leu Lys Ile Asn Leu Ile Gly His Arg Lys Arg Ile Leu Ala Ser Leu
    930                 935                 940                 
Gly Asp Arg Leu His Asp Asp Pro Pro Gln Lys Pro Pro Arg Ser Ile
945                 950                 955                 960 
Thr Leu Arg Glu Pro Ser Gly Asn His Thr Pro Pro Gln Leu Ser Pro
                965                 970                 975     
Ser Leu Ser Gln Ser Thr Tyr Thr Thr Gly Gly Ser Leu Asp Val Pro
            980                 985                 990         
His Ile Ile Met Gln Gly Asp Ala Arg Arg Arg Arg Asn Glu Asn Tyr
        995                 1000                1005            
Phe Asp Asp Ile Pro Arg Ser Lys Leu Glu Arg Gln Met Ala Gln Thr
    1010                1015                1020                
Gly Asp Trp Gly Glu Pro Ser Ile Thr Leu Arg Pro Pro Asn Glu Ala
1025                1030                1035                1040
Thr Ala Ser Thr Pro Val Gln Tyr Trp Gln His His Pro Glu Lys Leu
                1045                1050                1055    
Ile Phe Gln Ser Cys Asp Tyr Lys Ala Phe Tyr Leu Gly Ser Met Leu
            1060                1065                1070        
Ile Lys Glu Leu Arg Gly Thr Glu Ser Thr Gln Asp Ala Cys Ala Lys
        1075                1080                1085            
Met Arg Ala Asn Cys Gln Lys Ser Thr Glu Gln Met Lys Lys Val Pro
    1090                1095                1100                
Thr Ile Ile Leu Ser Val Ser Tyr Lys Gly Val Lys Phe Ile Asp Ala
1105                1110                1115                1120
Thr Asn Lys Asn Ile Ile Ala Glu His Glu Ile Arg Asn Ile Ser Cys
                1125                1130                1135    
Ala Ala Gln Asp Pro Glu Asp Leu Ser Thr Phe Ala Tyr Ile Thr Lys
            1140                1145                1150        
Asp Leu Lys Ser Asn His His Tyr Cys His Val Phe Thr Ala Phe Asp
        1155                1160                1165            
Val Asn Leu Ala Tyr Glu Ile Ile Leu Thr Leu Gly Gln Ala Phe Glu
    1170                1175                1180                
Val Ala Tyr Gln Leu Ala Leu Gln Ala Arg Lys Gly Gly His Ser Ser
1185                1190                1195                1200
Thr Leu Pro Glu Ser Phe Glu Asn Lys Pro Ser Lys Pro Ile Pro Lys
                1205                1210                1215    
Pro Arg Val Ser Ile Arg Lys Ser Val Asp Leu Leu His Ala Ser His
            1220                1225                1230        
Thr Gly Gln Glu Pro Ser Glu Arg His Thr Glu Glu Ala Leu Arg Lys
        1235                1240                1245            
Phe
    


<210> 8220
<211> 3909
<212> PRT
<213> Homo sapiens

<400> 8220
Met Thr Gly Asp Leu Gln Pro Arg Gln Val Ala Ser Ser Pro Gly His
 1               5                  10                  15      
Pro Ser Gln Pro Pro Leu Glu Asp Asn Thr Pro Ala Thr Arg Thr Thr
            20                  25                  30          
Lys Gly Ala Arg Glu Ala Gly Gly Gln Ala Gln Ala Met Glu Leu Pro
        35                  40                  45              
Glu Ala Gln Pro Arg Gln Ala Arg Asp Gly Glu Leu Lys Pro Pro Ser
    50                  55                  60                  
Leu Arg Gly Gln Ala Pro Ser Ser Thr Pro Gly Lys Arg Gly Ser Pro
65                  70                  75                  80  
Gln Thr Pro Pro Gly Arg Ser Pro Leu Gln Ala Pro Ser Arg Leu Ala
                85                  90                  95      
Gly Arg Ala Glu Gly Ser Pro Pro Gln Arg Tyr Ile Leu Gly Ile Ala
            100                 105                 110         
Ser Ser Arg Thr Lys Pro Thr Leu Asp Glu Thr Pro Glu Asn Pro Gln
        115                 120                 125             
Leu Glu Ala Ala Gln Leu Pro Glu Val Asp Thr Pro Gln Gly Pro Gly
    130                 135                 140                 
Thr Gly Ala Pro Leu Arg Pro Gly Leu Pro Arg Thr Glu Ala Gln Pro
145                 150                 155                 160 
Ala Ala Glu Glu Leu Gly Phe His Arg Cys Phe Gln Glu Pro Pro Ser
                165                 170                 175     
Ser Phe Thr Ser Thr Asn Tyr Thr Ser Pro Ser Ala Thr Pro Arg Pro
            180                 185                 190         
Pro Ala Pro Gly Pro Pro Gln Ser Arg Gly Thr Ser Pro Leu Gln Pro
        195                 200                 205             
Gly Ser Tyr Pro Glu Tyr Gln Ala Ser Gly Ala Asp Ser Trp Pro Pro
    210                 215                 220                 
Ala Ala Glu Asn Ser Phe Pro Gly Ala Asn Phe Gly Val Pro Pro Ala
225                 230                 235                 240 
Glu Pro Glu Pro Ile Pro Lys Gly Ser Arg Pro Gly Gly Ser Pro Arg
                245                 250                 255     
Gly Val Ser Phe Gln Phe Pro Phe Pro Ala Leu His Gly Ala Ser Thr
            260                 265                 270         
Lys Pro Phe Pro Ala Asp Val Ala Gly His Ala Phe Thr Asn Gly Pro
        275                 280                 285             
Leu Val Phe Ala Phe His Gln Pro Gln Gly Ala Trp Pro Glu Glu Ala
    290                 295                 300                 
Val Gly Thr Gly Pro Ala Tyr Pro Leu Pro Thr Gln Pro Ala Pro Ser
305                 310                 315                 320 
Pro Leu Pro Cys Tyr Gln Gly Gln Pro Gly Gly Leu Asn Arg His Ser
                325                 330                 335     
Asp Leu Ser Gly Ala Leu Ser Ser Pro Gly Ala Ala His Ser Ala Pro
            340                 345                 350         
Arg Pro Phe Ser Asp Ser Leu His Lys Ser Leu Thr Lys Ile Leu Pro
        355                 360                 365             
Glu Arg Pro Pro Ser Ala Gln Asp Gly Leu Gly Ser Thr Arg Gly Pro
    370                 375                 380                 
Pro Ser Ser Leu Pro Gln Arg His Phe Pro Gly Gln Ala Tyr Arg Ala
385                 390                 395                 400 
Ser Gly Val Asp Thr Ser Pro Gly Pro Pro Asp Thr Glu Leu Ala Ala
                405                 410                 415     
Pro Gly Pro Pro Pro Ala Arg Leu Pro Gln Leu Trp Asp Pro Thr Ala
            420                 425                 430         
Ala Pro Tyr Pro Thr Pro Pro Gly Gly Pro Leu Ala Ala Thr Arg Ser
        435                 440                 445             
Met Phe Phe Asn Gly Gln Pro Ser Pro Gly Gln Arg Leu Cys Leu Pro
    450                 455                 460                 
Gln Ser Ala Pro Leu Pro Trp Pro Gln Val Leu Pro Thr Ala Arg Pro
465                 470                 475                 480 
Ser Pro His Gly Met Glu Met Leu Ser Arg Leu Pro Phe Pro Ala Gly
                485                 490                 495     
Gly Pro Glu Trp Gln Gly Gly Ser Gln Gly Ala Leu Gly Thr Ala Gly
            500                 505                 510         
Lys Thr Pro Gly Pro Arg Glu Lys Leu Pro Ala Val Arg Ser Ser Gln
        515                 520                 525             
Gly Gly Ser Pro Ala Leu Phe Thr Tyr Asn Gly Met Thr Asp Pro Gly
    530                 535                 540                 
Ala Gln Pro Leu Phe Phe Gly Val Ala Gln Pro Gln Val Ser Pro His
545                 550                 555                 560 
Gly Thr Pro Ser Leu Pro Pro Pro Arg Val Val Gly Ala Ser Pro Ser
                565                 570                 575     
Glu Ser Pro Leu Pro Ser Pro Ala Thr Asn Thr Ala Gly Ser Thr Cys
            580                 585                 590         
Ser Ser Leu Ser Pro Met Ser Ser Ser Pro Ala Asn Pro Ser Ser Glu
        595                 600                 605             
Glu Ser Gln Leu Pro Gly Pro Leu Gly Pro Ser Ala Phe Phe His Pro
    610                 615                 620                 
Pro Thr His Pro Gln Glu Thr Gly Ser Pro Phe Pro Ser Pro Glu Pro
625                 630                 635                 640 
Pro His Ser Leu Pro Thr His Tyr Gln Pro Glu Pro Ala Lys Ala Phe
                645                 650                 655     
Pro Phe Pro Ala Asp Gly Leu Gly Ala Glu Gly Ala Phe Gln Cys Leu
            660                 665                 670         
Glu Glu Thr Pro Phe Pro His Glu Gly Pro Glu Val Gly Arg Gly Gly
        675                 680                 685             
Leu Gln Gly Phe Pro Arg Ala Pro Pro Pro Tyr Pro Thr His His Phe
    690                 695                 700                 
Ser Leu Ser Ser Ala Ser Leu Asp Gln Leu Asp Val Leu Leu Thr Cys
705                 710                 715                 720 
Arg Gln Cys Asp Arg Asn Tyr Ser Ser Leu Ala Ala Phe Leu Ala His
                725                 730                 735     
Arg Gln Phe Cys Gly Leu Leu Leu Ala Arg Ala Lys Asp Gly His Gln
            740                 745                 750         
Arg Ser Pro Gly Pro Pro Gly Leu Pro Ser Pro Pro Ala Ala Pro Arg
        755                 760                 765             
Val Pro Ala Asp Ala His Ala Gly Leu Leu Ser His Ala Lys Thr Phe
    770                 775                 780                 
Leu Leu Ala Gly Asp Ala Gln Ala Glu Gly Lys Asp Asp Pro Leu Arg
785                 790                 795                 800 
Thr Gly Phe Leu Pro Ser Leu Ala Ala Thr Pro Phe Pro Leu Pro Ala
                805                 810                 815     
Ser Asp Leu Asp Met Glu Asp Asp Ala Lys Leu Asp Ser Leu Ile Thr
            820                 825                 830         
Glu Ala Leu Asn Gly Met Glu Tyr Gln Ser Asp Asn Pro Glu Ile Asp
        835                 840                 845             
Ser Ser Phe Ile Asp Val Phe Ala Asp Glu Glu Pro Ser Gly Pro Arg
    850                 855                 860                 
Gly Pro Ser Ser Gly His Pro Leu Lys Ser Lys Ala Gly Val Thr Pro
865                 870                 875                 880 
Glu Ser Lys Ala Pro Pro Pro Leu Pro Ala Ala Thr Pro Asp Pro Gln
                885                 890                 895     
Thr Pro Arg Pro Gly Asp Arg Gly Cys Pro Ala Arg Gly Arg Pro Lys
            900                 905                 910         
Thr Arg Ser Leu Gly Leu Ala Pro Thr Glu Ala Asp Ala Pro Ser Gln
        915                 920                 925             
Gly Arg Gln Gln Arg Arg Gly Lys Gln Leu Lys Leu Phe Arg Lys Asp
    930                 935                 940                 
Leu Asp Ser Gly Gly Ala Ala Glu Gly Ser Gly Ser Gly Gly Gly Gly
945                 950                 955                 960 
Arg Ala Ser Gly Leu Arg Pro Arg Arg Asn Asp Gly Leu Gly Glu Arg
                965                 970                 975     
Pro Pro Pro Arg Pro Arg Arg Pro Arg Thr Gln Ala Pro Gly Ser Arg
            980                 985                 990         
Ala Asp Pro Ala Pro Arg Val Pro Arg Ala Ala Ala Leu Pro Glu Glu
        995                 1000                1005            
Thr Arg Ser Ser Arg Arg Arg Arg Leu Pro Pro Arg Lys Asp Pro Arg
    1010                1015                1020                
Lys Arg Lys Ala Arg Gly Gly Ala Trp Gly Lys Glu Leu Ile Leu Lys
1025                1030                1035                1040
Ile Asp Arg Arg Leu Arg Glu Tyr Asp Phe Ala Ser Glu Ser Glu Glu
                1045                1050                1055    
Asp Glu Gln Pro Pro Pro Arg Gly Pro Gly Phe Arg Gly Arg Arg Gly
            1060                1065                1070        
Arg Gly Glu Lys Arg Lys Glu Val Glu Leu Thr Gln Gly Pro Arg Glu
        1075                1080                1085            
Asp Glu Pro Gln Lys Pro Arg Lys Ala Ala Arg Gln Glu Ala Gly Gly
    1090                1095                1100                
Asp Gly Ala Pro Ala Asn Pro Glu Glu Pro Gly Gly Ser Arg Pro Gly
1105                1110                1115                1120
Pro Gly Arg Ser Pro Gln Ala Arg Gly Pro Ser Arg Ser Leu Glu Thr
                1125                1130                1135    
Gly Ala Ala Ala Arg Glu Gly Gly Pro Lys Cys Ala Asp Arg Pro Ser
            1140                1145                1150        
Val Ala Pro Lys Asp Pro Leu Gln Val Pro Thr Asn Thr Glu Thr Ser
        1155                1160                1165            
Glu Glu Thr Arg Pro Ser Leu Asp Phe Pro Gln Glu Ala Lys Glu Pro
    1170                1175                1180                
Glu Thr Ala Glu Glu Ser Ala Pro Asp Ser Thr Glu Phe Thr Glu Ala
1185                1190                1195                1200
Leu Arg Ser Pro Pro Ala Ala Cys Ala Gly Glu Met Gly Ala Ser Pro
                1205                1210                1215    
Gly Leu Leu Ile Pro Glu Gln Pro Pro Pro Ser Arg His Asp Thr Gly
            1220                1225                1230        
Thr Pro Lys Pro Ser Gly Ser Leu Ala Asn Thr Ala Pro His Gly Ser
        1235                1240                1245            
Ser Pro Thr Pro Gly Val Gly Ser Leu Leu Gly Gly Pro Gly Gly Thr
    1250                1255                1260                
Gln Ala Pro Val Ser His Asn Ser Lys Asp Pro Pro Ala Arg Gln Pro
1265                1270                1275                1280
Gly Glu Phe Leu Ala Pro Val Ala Asn Pro Ser Ser Thr Ala Cys Pro
                1285                1290                1295    
Lys Pro Ser Val Leu Ser Ser Lys Ile Ser Ser Phe Gly Cys Asp Pro
            1300                1305                1310        
Ala Gly Phe Asn Arg Asp Pro Leu Gly Val Pro Val Ala Lys Lys Gly
        1315                1320                1325            
Pro Gln Pro Tyr Ser Ser Pro His Ser Glu Leu Phe Leu Gly Pro Lys
    1330                1335                1340                
Asp Leu Ala Gly Cys Phe Leu Glu Glu Leu His Pro Lys Pro Ser Ala
1345                1350                1355                1360
Arg Asp Ala Pro Pro Ala Ser Ser Ser Cys Leu Cys Gln Asp Gly Glu
                1365                1370                1375    
Asp Ala Gly Ser Leu Glu Pro Gln Leu Pro Arg Ser Pro Pro Gly Thr
            1380                1385                1390        
Ala Glu Thr Glu Pro Gly Arg Ala Ala Ser Pro Pro Thr Leu Glu Ser
        1395                1400                1405            
Ser Ser Leu Phe Pro Asp Leu Pro Val Asp Arg Phe Asp Pro Pro Leu
    1410                1415                1420                
Tyr Gly Ser Leu Ser Ala Asn Arg Asp Ser Gly Leu Pro Phe Ala Cys
1425                1430                1435                1440
Ala Asp Pro Pro Gln Lys Thr Val Pro Ser Asp Pro Pro Tyr Pro Ser
                1445                1450                1455    
Phe Leu Leu Leu Glu Glu Val Ser Pro Met Leu Pro Ser His Phe Pro
            1460                1465                1470        
Asp Leu Ser Gly Gly Lys Val Leu Ser Lys Thr Cys Pro Pro Glu Arg
        1475                1480                1485            
Thr Val Val Pro Gly Ala Ala Pro Ser Leu Pro Gly Lys Gly Ser Gly
    1490                1495                1500                
Cys Ser Val Ala Leu Met Ser His Leu Ser Glu Asp Glu Leu Glu Ile
1505                1510                1515                1520
Gln Lys Leu Val Thr Glu Leu Glu Ser Gln Leu Gln Arg Ser Lys Asp
                1525                1530                1535    
Thr Arg Gly Ala Pro Arg Glu Leu Ala Glu Ala Glu Ser Val Gly Arg
            1540                1545                1550        
Val Glu Leu Gly Thr Gly Thr Glu Pro Pro Ser Gln Arg Arg Thr Cys
        1555                1560                1565            
Gln Ala Thr Val Pro His Glu Asp Thr Phe Ser Ala Ala Asp Leu Thr
    1570                1575                1580                
Arg Val Gly Glu Ser Thr Ala His Arg Glu Gly Ala Glu Ser Ala Val
1585                1590                1595                1600
Ala Thr Val Glu Ala Val Gln Gly Arg Pro Gly Gly Thr Trp Pro Cys
                1605                1610                1615    
Pro Ala Ser Phe His Pro Gly His Ala Ala Leu Leu Pro Cys Ala Gln
            1620                1625                1630        
Glu Asp Leu Val Ser Gly Ala Pro Phe Ser Pro Arg Gly Ala Asn Phe
        1635                1640                1645            
His Phe Gln Pro Val Gln Lys Ala Gly Ala Ser Lys Thr Gly Leu Cys
    1650                1655                1660                
Gln Ala Glu Gly Asp Ser Arg Pro Pro Gln Asp Val Cys Leu Pro Glu
1665                1670                1675                1680
Pro Ser Lys Gln Pro Gly Pro Gln Leu Asp Ala Gly Ser Leu Ala Lys
                1685                1690                1695    
Cys Ser Pro Asp Gln Glu Leu Ser Phe Pro Lys Asn Lys Glu Ala Ala
            1700                1705                1710        
Ser Ser Gln Glu Ser Glu Asp Ser Leu Arg Leu Leu Pro Cys Glu Gln
        1715                1720                1725            
Arg Gly Gly Phe Leu Pro Glu Pro Gly Thr Ala Asp Gln Pro His Arg
    1730                1735                1740                
Gly Ala Pro Ala Pro Glu Ala Phe Gly Ser Pro Ala Val His Leu Ala
1745                1750                1755                1760
Pro Asp Leu Ala Phe Gln Gly Asp Gly Ala Pro Pro Leu Asp Ala Thr
                1765                1770                1775    
Trp Pro Phe Gly Ala Ser Pro Ser His Ala Ala Gln Gly His Ser Ala
            1780                1785                1790        
Gly Arg Ala Gly Gly His Leu His Pro Thr Ala Gly Arg Pro Gly Phe
        1795                1800                1805            
Glu Gly Asn Glu Phe Ala Pro Ala Gly Ala Ser Ser Leu Thr Ala Pro
    1810                1815                1820                
Arg Gly Arg Glu Ala Trp Leu Val Pro Val Pro Ser Pro Ala Cys Val
1825                1830                1835                1840
Ser Asn Thr His Pro Ser Arg Arg Ser Gln Asp Pro Ala Leu Ser Pro
                1845                1850                1855    
Pro Ile Arg Gln Leu Gln Leu Pro Gly Pro Gly Val Ala Lys Ser Lys
            1860                1865                1870        
Asp Gly Ile Leu Gly Leu Gln Glu Leu Thr Pro Ala Ala Gln Ser Pro
        1875                1880                1885            
Pro Arg Val Asn Pro Ser Gly Leu Glu Gly Gly Thr Val Glu Gly Gly
    1890                1895                1900                
Lys Val Ala Cys Gly Pro Ala Gln Gly Ser Pro Gly Gly Val Gln Val
1905                1910                1915                1920
Thr Thr Leu Pro Ala Val Ala Gly His Gln Leu Gly Leu Glu Ala Asp
                1925                1930                1935    
Gly His Trp Gly Leu Leu Gly Gln Ala Glu Lys Thr Gln Gly Gln Gly
            1940                1945                1950        
Thr Ala Asn Gln Leu Gln Pro Glu Asn Gly Val Ser Pro Gly Gly Thr
        1955                1960                1965            
Asp Asn His Ala Ser Val Asn Ala Ser Pro Lys Thr Ala Leu Thr Gly
    1970                1975                1980                
Pro Thr Glu Gly Ala Val Leu Leu Glu Lys Cys Lys Gly Ser Arg Ala
1985                1990                1995                2000
Ala Met Ser Leu Gln Glu Glu Ala Glu Pro Thr Pro Ser Pro Pro Ser
                2005                2010                2015    
Pro Asn Arg Glu Ser Leu Ala Leu Ala Leu Thr Ala Ala His Ser Arg
            2020                2025                2030        
Ser Gly Ser Glu Gly Arg Thr Pro Glu Arg Ala Ser Ser Pro Gly Leu
        2035                2040                2045            
Asn Lys Pro Leu Leu Ala Thr Gly Asp Ser Pro Ala Pro Ser Val Gly
    2050                2055                2060                
Asp Leu Ala Ala Cys Ala Pro Ser Pro Thr Ser Ala Ala His Met Pro
2065                2070                2075                2080
Cys Ser Leu Gly Pro Leu Pro Arg Glu Asp Pro Leu Thr Ser Pro Ser
                2085                2090                2095    
Arg Ala Gln Gly Gly Leu Gly Gly Gln Leu Pro Ala Ser Pro Ser Cys
            2100                2105                2110        
Arg Asp Pro Pro Gly Pro Gln Gln Leu Leu Ala Cys Ser Pro Ala Trp
        2115                2120                2125            
Ala Pro Leu Glu Glu Ala Asp Gly Val Gln Ala Thr Thr Asp Thr Gly
    2130                2135                2140                
Ala Glu Asp Ser Pro Val Ala Pro Pro Ser Leu Thr Thr Ser Pro Cys
2145                2150                2155                2160
Asp Pro Lys Glu Ala Leu Ala Gly Cys Leu Leu Gln Gly Glu Gly Ser
                2165                2170                2175    
Pro Leu Glu Asp Pro Ser Ser Trp Pro Pro Gly Ser Val Ser Ala Val
            2180                2185                2190        
Thr Cys Thr His Ser Gly Asp Thr Pro Lys Asp Ser Thr Leu Arg Ile
        2195                2200                2205            
Pro Glu Asp Ser Arg Lys Glu Lys Leu Trp Glu Ser Pro Gly Arg Ala
    2210                2215                2220                
Thr Ser Pro Pro Leu Ala Gly Ala Val Ser Pro Ser Val Ala Val Arg
2225                2230                2235                2240
Ala Thr Gly Leu Ser Ser Thr Pro Thr Gly Asp Glu Ala Gln Ala Gly
                2245                2250                2255    
Arg Gly Leu Pro Gly Pro Asp Pro Gln Ser Arg Gly Ala Pro Pro His
            2260                2265                2270        
Thr Asn Pro Asp Arg Met Pro Arg Gly His Ser Ser Tyr Ser Pro Ser
        2275                2280                2285            
Asn Thr Ala Arg Leu Gly His Arg Glu Gly Gln Ala Val Thr Ala Val
    2290                2295                2300                
Pro Thr Glu Pro Pro Thr Leu Gln Gly Ala Gly Pro Asp Ser Pro Ala
2305                2310                2315                2320
Cys Leu Glu Gly Glu Met Gly Thr Ser Ser Lys Glu Pro Glu Asp Pro
                2325                2330                2335    
Gly Thr Pro Glu Thr Gly Arg Ser Gly Ala Thr Lys Met Pro Arg Val
            2340                2345                2350        
Thr Cys Pro Ser Thr Gly Leu Gly Leu Gly Arg Thr Thr Ala Pro Ser
        2355                2360                2365            
Ser Thr Ala Ser Asp Phe Gln Ser Asp Ser Pro Gln Ser His Arg Asn
    2370                2375                2380                
Ala Ser His Gln Thr Pro Gln Gly Asp Pro Leu Gly Pro Gln Asp Leu
2385                2390                2395                2400
Lys Gln Arg Ser Arg Gly Tyr Lys Lys Lys Pro Ala Ser Thr Glu Asn
                2405                2410                2415    
Gly Gln Trp Lys Gly Gln Ala Pro His Gly Pro Val Thr Cys Glu Val
            2420                2425                2430        
Cys Ala Ala Ser Phe Arg Ser Gly Pro Gly Leu Ser Arg His Lys Ala
        2435                2440                2445            
Arg Lys His Arg Pro His Pro Gly Ala Pro Ala Glu Pro Ser Pro Ala
    2450                2455                2460                
Ala Leu Pro Ala Gln Gln Pro Leu Glu Pro Leu Ala Gln Lys Cys Gln
2465                2470                2475                2480
Pro Pro Arg Lys Lys Ser His Arg Val Ser Gly Lys Glu Arg Pro Asn
                2485                2490                2495    
His Ser Arg Gly Asp Pro Ser His Val Thr Gln Pro Pro Pro Ala Gln
            2500                2505                2510        
Gly Ser Lys Glu Val Leu Arg Ala Pro Gly Ser Pro His Ser Gln Gln
        2515                2520                2525            
Leu His Pro Pro Ser Pro Thr Glu His Glu Val Asp Val Lys Thr Pro
    2530                2535                2540                
Ala Ser Lys Pro Arg Pro Asp Gln Ala Arg Glu Asp Glu Leu His Pro
2545                2550                2555                2560
Lys Gln Ala Glu Lys Arg Glu Gly Arg Arg Trp Arg Arg Glu Pro Thr
                2565                2570                2575    
Val Asp Ser Pro Ser His Ser Glu Gly Lys Ser Asn Lys Lys Arg Gly
            2580                2585                2590        
Lys Leu Arg Gly Arg Arg Leu Arg Glu Glu Ser Ile Leu Pro Val Ser
        2595                2600                2605            
Ala Asp Val Ile Ser Asp Gly Arg Gly Ser Arg Pro Ser Pro Ala Met
    2610                2615                2620                
Ala Ser Tyr Ala Ala Ser Pro Ser His Cys Leu Ser Val Glu Gly Gly
2625                2630                2635                2640
Pro Glu Ala Asp Gly Glu Gln Pro Pro Arg Leu Ala Thr Leu Gly Pro
                2645                2650                2655    
Gly Val Met Glu Gly Ala Ala Glu Thr Asp Gln Glu Ala Leu Cys Ala
            2660                2665                2670        
Gly Glu Thr Gly Ala Gln Lys Pro Pro Gly Asp Arg Met Leu Cys Pro
        2675                2680                2685            
Gly Arg Met Asp Gly Ala Ala Leu Gly Glu Gln Pro Thr Gly Gln Lys
    2690                2695                2700                
Gly Ala Ser Ala Arg Gly Phe Trp Gly Pro Arg Glu Thr Lys Ala Leu
2705                2710                2715                2720
Gly Val Cys Lys Glu Ser Gly Ser Glu Pro Ala Glu Asp Ser Ser Arg
                2725                2730                2735    
Ala His Ser Arg Ser Glu Glu Gly Val Trp Glu Glu Asn Thr Pro Pro
            2740                2745                2750        
Leu Gly Pro Leu Gly Phe Pro Glu Thr Ser Ser Ser Pro Ala Asp Ser
        2755                2760                2765            
Thr Thr Ser Ser Cys Leu Gln Gly Leu Pro Asp Asn Pro Asp Thr Gln
    2770                2775                2780                
Gly Gly Val Gln Gly Pro Glu Gly Pro Thr Pro Asp Ala Ser Gly Ser
2785                2790                2795                2800
Ser Ala Lys Asp Pro Pro Ser Leu Phe Asp Asp Glu Val Ser Phe Ser
                2805                2810                2815    
Gln Leu Phe Pro Pro Gly Gly Arg Leu Thr Arg Lys Arg Asn Pro His
            2820                2825                2830        
Val Tyr Gly Lys Arg Cys Glu Lys Pro Val Leu Pro Leu Pro Thr Gln
        2835                2840                2845            
Pro Ser Phe Glu Glu Gly Gly Asp Pro Thr Leu Gly Pro Ala Arg Leu
    2850                2855                2860                
Pro Thr Asp Leu Ser Asp Ser Ser Ser Leu Cys Leu Cys His Glu Asp
2865                2870                2875                2880
Pro Trp Glu Asp Glu Asp Pro Ala Gly Leu Pro Glu Ser Phe Leu Leu
                2885                2890                2895    
Asp Gly Phe Leu Asn Ser Arg Val Pro Gly Ile Asp Pro Trp Ala Pro
            2900                2905                2910        
Gly Leu Ser Leu Trp Ala Leu Glu Pro Ser Arg Glu Ala Gly Ala Glu
        2915                2920                2925            
Lys Leu Pro Ser His Cys Pro Glu Asp Asp Arg Pro Glu Ala Ile Pro
    2930                2935                2940                
Glu Leu His Met Val Pro Ala Ala Trp Arg Gly Leu Glu Met Pro Ala
2945                2950                2955                2960
Pro Ala Asp Asp Ser Ser Ser Ser Leu Gly Asp Val Ser Pro Glu Pro
                2965                2970                2975    
Pro Ser Leu Glu Arg Glu Arg Cys Asp Gly Gly Leu Pro Gly Asn Thr
            2980                2985                2990        
His Leu Leu Pro Leu Arg Ala Thr Asp Phe Glu Val Leu Ser Thr Lys
        2995                3000                3005            
Phe Glu Met Gln Asp Leu Cys Phe Leu Gly Pro Phe Glu Asp Pro Val
    3010                3015                3020                
Gly Leu Pro Gly Pro Ser Phe Leu Asp Phe Glu Gly Thr Ala Ser Ser
3025                3030                3035                3040
Gln Gly Pro Gln Ser Arg Arg Thr Glu Glu Ala Ala Gly Ala Gly Arg
                3045                3050                3055    
Ala Gln Gly Arg Gly Arg Pro Ala Lys Gly Arg Arg Ala Ser Tyr Lys
            3060                3065                3070        
Cys Lys Val Cys Phe Gln Arg Phe Arg Ser Leu Gly Glu Leu Asp Leu
        3075                3080                3085            
His Lys Leu Ala His Thr Pro Ala Pro Pro Pro Thr Cys Tyr Met Cys
    3090                3095                3100                
Val Glu Arg Arg Phe Gly Ser Arg Glu Leu Leu Arg Gly His Leu Gln
3105                3110                3115                3120
Glu Arg His Ala Gln Ser Lys Ala Gly Pro Trp Ala Cys Gly Met Cys
                3125                3130                3135    
Leu Lys Glu Val Ala Asp Val Trp Met Tyr Asn Glu His Leu Arg Glu
            3140                3145                3150        
His Ala Val Arg Phe Ala Arg Arg Gly Gln Ala Arg Arg Ser Leu Gly
        3155                3160                3165            
Asp Leu Pro Gly Gly Leu Glu Gly Ser Ser Ala Val Ala His Leu Leu
    3170                3175                3180                
Asn Ser Ile Thr Glu Pro Ala Pro Lys His His Arg Gly Lys Arg Ser
3185                3190                3195                3200
Ala Gly Lys Ala Ala Gly Ser Pro Gly Asp Pro Trp Gly Gln Glu Gly
                3205                3210                3215    
Glu Ala Lys Lys Asp Ser Pro Gly Glu Arg Ala Lys Pro Arg Ala Arg
            3220                3225                3230        
Ser Thr Pro Ser Asn Pro Asp Gly Ala Ala Thr Pro Asp Ser Ala Ser
        3235                3240                3245            
Ala Thr Ala Leu Ala Asp Ala Gly Ser Pro Gly Pro Pro Arg Thr Thr
    3250                3255                3260                
Pro Ser Pro Ser Pro Asp Pro Trp Ala Gly Gly Glu Pro Leu Leu Gln
3265                3270                3275                3280
Ala Thr Pro Val His Glu Ala Cys Lys Asp Pro Ser Arg Asp Cys His
                3285                3290                3295    
His Cys Gly Lys Arg Phe Pro Lys Pro Phe Lys Leu Gln Arg His Leu
            3300                3305                3310        
Ala Val His Ser Pro Gln Arg Val Tyr Leu Cys Pro Arg Cys Pro Arg
        3315                3320                3325            
Val Tyr Pro Glu His Gly Glu Leu Leu Ala His Leu Gly Gly Ala His
    3330                3335                3340                
Gly Leu Leu Glu Arg Pro Glu Leu Gln His Thr Pro Leu Tyr Ala Cys
3345                3350                3355                3360
Glu Leu Cys Ala Thr Val Met Arg Ile Ile Lys Lys Ser Phe Ala Cys
                3365                3370                3375    
Ser Ser Cys Asn Tyr Thr Phe Ala Lys Lys Glu Gln Phe Asp Arg His
            3380                3385                3390        
Met Asn Lys His Leu Arg Gly Gly Arg Gln Pro Phe Ala Phe Arg Gly
        3395                3400                3405            
Val Arg Arg Pro Gly Ala Pro Gly Gln Lys Ala Arg Ala Leu Glu Gly
    3410                3415                3420                
Thr Leu Pro Ser Lys Arg Arg Arg Val Ala Met Pro Gly Ser Ala Pro
3425                3430                3435                3440
Gly Pro Gly Glu Asp Arg Pro Pro Pro Arg Gly Ser Ser Pro Ile Leu
                3445                3450                3455    
Ser Glu Gly Ser Leu Pro Ala Leu Leu His Leu Cys Ser Glu Val Ala
            3460                3465                3470        
Pro Ser Thr Thr Lys Gly Trp Pro Glu Thr Leu Glu Arg Pro Val Asp
        3475                3480                3485            
Pro Val Thr His Pro Ile Arg Gly Cys Glu Leu Pro Ser Asn His Gln
    3490                3495                3500                
Glu Cys Pro Pro Pro Ser Leu Ser Pro Phe Pro Ala Ala Leu Ala Asp
3505                3510                3515                3520
Gly Arg Gly Asp Cys Ala Leu Asp Gly Ala Leu Glu Arg Pro Glu Asn
                3525                3530                3535    
Glu Ala Ser Pro Gly Ser Pro Gly Pro Leu Leu Gln Gln Ala Leu Pro
            3540                3545                3550        
Leu Gly Ala Ser Leu Pro Arg Pro Gly Ala Arg Gly Gln Asp Ala Glu
        3555                3560                3565            
Gly Lys Arg Ala Pro Leu Val Phe Ser Gly Lys Arg Arg Ala Pro Gly
    3570                3575                3580                
Ala Arg Gly Arg Cys Ala Pro Asp His Phe Gln Glu Asp His Leu Leu
3585                3590                3595                3600
Gln Lys Glu Lys Glu Val Ser Ser Ser His Met Val Ser Glu Gly Gly
                3605                3610                3615    
Pro Arg Gly Thr Phe His Lys Gly Ser Ala Thr Lys Pro Ala Gly Cys
            3620                3625                3630        
Gln Ser Ser Ser Lys Asp Arg Ser Ala Ala Ser Thr Pro Ser Lys Ala
        3635                3640                3645            
Leu Lys Phe Pro Val His Pro Arg Lys Ala Val Gly Ser Leu Ala Pro
    3650                3655                3660                
Gly Glu Leu Ala Arg Gly Thr Glu Asn Gly Met Lys Pro Ala Thr Pro
3665                3670                3675                3680
Lys Ala Lys Pro Gly Pro Ser Ser Gln Gly Ser Gly Ser Pro Arg Pro
                3685                3690                3695    
Gly Thr Lys Thr Gly Gly Gly Ser Gln Pro Gln Pro Ala Ser Gly Gln
            3700                3705                3710        
Leu Gln Ser Glu Thr Ala Thr Thr Pro Ala Lys Pro Ser Phe Pro Ser
        3715                3720                3725            
Arg Ser Pro Ala Pro Glu Arg Leu Pro Ala Arg Ala Gln Ala Lys Ser
    3730                3735                3740                
Cys Thr Lys Gly Pro Arg Glu Ala Gly Glu Gln Gly Pro His Gly Ser
3745                3750                3755                3760
Leu Gly Pro Lys Glu Lys Gly Glu Ser Ser Thr Lys Arg Lys Lys Gly
                3765                3770                3775    
Gln Val Pro Gly Pro Ala Arg Ser Glu Ser Val Gly Ser Phe Gly Arg
            3780                3785                3790        
Ala Pro Ser Ala Pro Asp Lys Pro Pro Arg Thr Pro Arg Lys Gln Ala
        3795                3800                3805            
Thr Pro Ser Arg Val Leu Pro Thr Lys Pro Lys Pro Asn Ser Gln Asn
    3810                3815                3820                
Lys Pro Arg Pro Pro Pro Ser Glu Gln Arg Lys Ala Glu Pro Gly His
3825                3830                3835                3840
Thr Gln Arg Lys Asp Arg Leu Gly Lys Ala Phe Pro Gln Gly Arg Pro
                3845                3850                3855    
Leu Leu Arg Pro Pro Lys Arg Gly Thr Ala Val His Gly Ala Glu Pro
            3860                3865                3870        
Ala Glu Pro His Thr His Arg Thr Ala Glu Ala Gln Ser Asp Leu Leu
        3875                3880                3885            
Ser Gln Leu Phe Gly Gln Arg Leu Thr Gly Phe Lys Ile Pro Leu Lys
    3890                3895                3900                
Lys Asp Ala Ser Glu
3905                


<210> 8221
<211> 936
<212> PRT
<213> Homo sapiens

<400> 8221
Met Leu Leu Ala Pro Gln Gly Arg Ser Phe Ser Lys Lys Arg Met Gly
 1               5                  10                  15      
Leu Asn Arg Trp Lys Arg Phe Thr Arg Lys Pro Ser Pro Lys Pro Thr
            20                  25                  30          
Phe Gly Pro Asp Ser Val Glu His Trp Ile Lys Arg Val Glu Lys Ala
        35                  40                  45              
Ser Glu Phe Ala Val Ser Asn Ala Phe Phe Thr Arg Asn Ser Asp Leu
    50                  55                  60                  
Pro Arg Ser Pro Trp Gly Gln Ile Thr Asp Leu Lys Thr Ser Glu Gln
65                  70                  75                  80  
Ile Glu Asp His Asp Glu Ile Tyr Ala Glu Ala Gln Glu Leu Val Asn
                85                  90                  95      
Asp Trp Leu Asp Thr Lys Leu Lys Gln Glu Leu Ala Ser Glu Glu Glu
            100                 105                 110         
Gly Asp Ala Lys Asn Thr Val Ser Ser Val Thr Ile Met Pro Glu Ala
        115                 120                 125             
Asn Gly His Leu Lys Tyr Asp Lys Phe Asp Asp Leu Cys Gly Tyr Leu
    130                 135                 140                 
Glu Glu Glu Glu Glu Ser Thr Thr Val Gln Lys Phe Ile Asp His Leu
145                 150                 155                 160 
Leu His Lys Asn Val Val Asp Ser Ala Met Met Glu Asp Leu Gly Arg
                165                 170                 175     
Lys Glu Asn Gln Asp Lys Lys Gln Gln Lys Asp Pro Arg Leu Thr Met
            180                 185                 190         
Glu Met Arg His Lys Gln Val Lys Glu Asn Arg Leu Arg Arg Glu Lys
        195                 200                 205             
Glu Leu Glu Tyr Gln Arg Ile Glu Lys Thr Leu Lys Lys Ser Ala Phe
    210                 215                 220                 
Leu Glu Ala Gln Cys Leu Val Gln Glu Glu Lys Lys Arg Lys Ala Leu
225                 230                 235                 240 
Glu Ala Lys Lys Glu Glu Glu Glu Ile Gln Arg Glu Met Val Lys Leu
                245                 250                 255     
Arg Arg Glu Ile Ile Glu Arg Arg Arg Thr Val Lys Ala Ala Trp Lys
            260                 265                 270         
Ile Glu Lys Lys Arg Gln Glu Glu Asn Ser Gln Asn Ser Ser Glu Lys
        275                 280                 285             
Val Met Phe Gln Ser Thr His Ile Leu Pro Asp Glu Glu Lys Met Val
    290                 295                 300                 
Lys Glu Arg Lys Arg Lys Leu Lys Glu Val Leu Ile Gln Thr Phe Lys
305                 310                 315                 320 
Glu Asn Gln Gln Cys Gln Lys Arg Tyr Phe Ala Ala Trp His Lys Leu
                325                 330                 335     
Ile Leu Asp His Arg Ile Lys Leu Gly Lys Ala Gly Thr Leu Ser Asp
            340                 345                 350         
Trp Lys Ile Gln Leu Lys Val Leu Arg Ala Trp Arg Asp Tyr Thr Arg
        355                 360                 365             
Phe Gln Lys Leu Glu Arg Glu Thr Gln Ala Leu Glu Asn Asp Leu Arg
    370                 375                 380                 
Glu Glu Asn Arg Lys Gln Gln Leu Ala Thr Glu Tyr Asn Arg Lys Gln
385                 390                 395                 400 
Val Leu Arg His Cys Phe Thr Glu Trp Gln His Trp His Gly Ala Glu
                405                 410                 415     
Leu Leu Lys Arg Glu Leu Ala Leu Thr Lys Glu Glu Thr Arg Lys Lys
            420                 425                 430         
Met Asp Ala Leu Leu Gln Ala Ala Ser Leu Gly Lys Leu Ser Ala Asn
        435                 440                 445             
Gly Leu Ser Gly Ile Ser Leu Pro Glu Glu Ala Thr Ala Met Val Gly
    450                 455                 460                 
Pro Pro Val Lys Asn Gly Gln Glu Thr Ala Val Pro Pro Leu Trp Glu
465                 470                 475                 480 
Lys Pro Pro Leu Gly Ser Ser Gly Cys Met Leu Ser Pro Pro Leu Gly
                485                 490                 495     
Arg Thr Thr Thr Gly Asn Leu Gln Gly Ser Leu Gln Asn Val Ser Leu
            500                 505                 510         
Ser Ala Pro Gly Asn Lys Gln His Lys Thr Leu Gly Ala Glu Pro Ser
        515                 520                 525             
Gln Gln Pro Gly Ser Asn Glu Thr Leu Arg Thr Thr Ser Gln Lys Ala
    530                 535                 540                 
Glu Pro Leu Cys Leu Gly His Phe His Asn Arg His Val Phe Gln Gln
545                 550                 555                 560 
Gln Leu Ile Glu Lys Gln Lys Lys Lys Leu Gln Glu Gln Gln Lys Thr
                565                 570                 575     
Ile Leu Glu Leu Lys Lys Asn Leu Gln Leu Ala Glu Ala Gln Trp Ala
            580                 585                 590         
Ala Glu His Ala Leu Ala Val Thr Glu Ala Gln Ser His Leu Leu Ser
        595                 600                 605             
Lys Pro Arg Glu Glu Glu Pro Arg Thr Cys Gln Met Leu Val Asn Ser
    610                 615                 620                 
Pro Val Ala Ser Pro Gly Thr Glu Gly Arg Ser Asp Ser Arg Asn Ser
625                 630                 635                 640 
Leu Ser Gly Leu Arg Arg Lys Pro Lys Gln Leu Met Thr Pro His Pro
                645                 650                 655     
Ile Leu Lys Ala Met Glu Glu Arg Ala Ile Gln Arg Ala Glu Cys Arg
            660                 665                 670         
Arg Ile Leu Ala Glu Lys Lys Lys Lys Gln Glu Glu Glu Lys Leu Ala
        675                 680                 685             
Gln Leu Lys Ala Gln Glu Glu Glu Arg Gln Lys Arg Glu Ala Glu Glu
    690                 695                 700                 
Lys Glu Ala Gln Leu Glu Arg Lys Arg Glu Glu Lys Arg Leu Lys Lys
705                 710                 715                 720 
Met Lys Glu Leu Glu Lys Gln Lys Arg Ile Lys Arg Asn Gln Gln Leu
                725                 730                 735     
Glu Ala Ile Ala Lys Glu His Tyr Glu Arg Val Leu Leu Arg Lys Lys
            740                 745                 750         
Gly Leu Glu Pro Trp Lys Arg Leu Arg Met Gln Ser Lys Gln Asn Ile
        755                 760                 765             
Gln Val Ala Glu Glu His Tyr Ser Leu Phe Leu Gln Arg Lys Tyr Met
    770                 775                 780                 
Leu Thr Trp Phe Gln Arg Ser Gln Glu Ser Leu Ala Arg Lys Met Ala
785                 790                 795                 800 
Gln Ala Asp Gln Phe Tyr Ser Gln Ile Leu Leu Lys Arg Val Ile Gln
                805                 810                 815     
Ser Trp Leu Gln Tyr Val Ile Asp Leu Gln Glu Glu Val Arg Lys Phe
            820                 825                 830         
Cys Val His Phe Leu Gln Lys Lys Ile Phe Arg Ala Trp Phe Asn Met
        835                 840                 845             
Val Arg Glu Val Lys Ile Asp Ser Gln Gly Lys His Glu Ile Ala Ala
    850                 855                 860                 
Glu His Ser Asp Arg Arg Ile Leu Trp Ile Thr Leu Arg Thr Trp Lys
865                 870                 875                 880 
Lys Phe Val Lys Phe Met Lys Glu Glu Arg Val Lys Glu Glu Arg Arg
                885                 890                 895     
Gln Gln Leu Arg Arg Lys Val Val Glu Ile Leu Pro Asp Phe Gln Val
            900                 905                 910         
Pro Gly Arg Tyr His Glu Leu Tyr Gln Gln Ser Asp Thr Trp Ser Leu
        915                 920                 925             
Ser Lys Thr Ser Leu Val Asn Glu
    930                 935     


<210> 8222
<211> 398
<212> PRT
<213> Homo sapiens

<400> 8222
Met Lys Lys Lys Val Leu Ser Asp Ser Glu Asp Glu Glu Lys Asp Ala
 1               5                  10                  15      
Asp Val Pro Gly Thr Ser Thr Arg Lys Arg Lys Asp His Gln Pro Arg
            20                  25                  30          
Arg Arg Leu Arg Asn Arg Ala Gln Ser Tyr Asp Ile Gln Ala Trp Lys
        35                  40                  45              
Lys Gln Cys Glu Glu Leu Leu Asn Leu Ile Phe Gln Cys Glu Asp Ser
    50                  55                  60                  
Glu Pro Phe Arg Gln Pro Val Asp Leu Leu Glu Tyr Pro Asp Tyr Arg
65                  70                  75                  80  
Asp Ile Ile Asp Thr Pro Met Asp Phe Ala Thr Val Arg Glu Thr Leu
                85                  90                  95      
Glu Ala Gly Asn Tyr Glu Ser Pro Met Glu Leu Cys Lys Asp Val Arg
            100                 105                 110         
Leu Ile Phe Ser Asn Ser Lys Ala Tyr Thr Pro Ser Lys Arg Ser Arg
        115                 120                 125             
Ile Tyr Ser Met Ser Leu Arg Leu Ser Ala Phe Phe Glu Glu His Ile
    130                 135                 140                 
Ser Ser Val Leu Ser Asp Tyr Lys Ser Ala Leu Arg Phe His Lys Arg
145                 150                 155                 160 
Asn Thr Ile Thr Lys Arg Arg Lys Lys Arg Asn Arg Ser Ser Ser Val
                165                 170                 175     
Ser Ser Ser Ala Ala Ser Ser Pro Glu Arg Lys Lys Arg Ile Leu Lys
            180                 185                 190         
Pro Gln Leu Lys Ser Glu Ser Ser Thr Ser Ala Phe Ser Thr Pro Thr
        195                 200                 205             
Arg Ser Ile Pro Pro Arg His Asn Ala Ala Gln Ile Asn Gly Lys Thr
    210                 215                 220                 
Glu Ser Ser Ser Val Val Arg Thr Arg Ser Asn Arg Val Val Val Asp
225                 230                 235                 240 
Pro Val Val Thr Glu Gln Pro Ser Thr Ser Ser Ala Ala Lys Thr Phe
                245                 250                 255     
Ile Thr Lys Ala Asn Ala Ser Ala Ile Pro Gly Lys Thr Ile Leu Glu
            260                 265                 270         
Asn Ser Val Lys His Ser Lys Ala Leu Asn Thr Leu Ser Ser Pro Gly
        275                 280                 285             
Gln Ser Ser Phe Ser His Gly Thr Arg Asn Asn Ser Ala Lys Glu Asn
    290                 295                 300                 
Met Glu Lys Glu Lys Pro Val Lys Arg Lys Met Lys Ser Ser Val Leu
305                 310                 315                 320 
Pro Lys Ala Ser Thr Leu Ser Lys Ser Ser Ala Val Ile Glu Gln Gly
                325                 330                 335     
Asp Cys Lys Asn Asn Ala Leu Val Pro Gly Thr Ile Gln Val Asn Gly
            340                 345                 350         
His Gly Gly Gln Pro Ser Lys Leu Val Lys Arg Gly Pro Gly Arg Lys
        355                 360                 365             
Pro Lys Val Glu Val Lys Ile Val Val Lys Leu Tyr Thr Arg Lys Gly
    370                 375                 380                 
Val Glu Ser Pro Lys Ser Tyr Ser Met Gln Ser Gln Lys Ile
385                 390                 395             


<210> 8223
<211> 1821
<212> PRT
<213> Homo sapiens

<400> 8223
Met Ser Cys Glu Arg Lys Gly Leu Ser Glu Leu Arg Ser Glu Leu Tyr
 1               5                  10                  15      
Phe Leu Ile Ala Arg Phe Leu Glu Asp Gly Pro Cys Gln Gln Ala Ala
            20                  25                  30          
Gln Val Leu Ile Arg Glu Val Ala Glu Lys Glu Leu Leu Pro Arg Arg
        35                  40                  45              
Thr Asp Trp Thr Gly Lys Glu His Pro Arg Thr Tyr Gln Asn Leu Val
    50                  55                  60                  
Lys Tyr Tyr Arg His Leu Ala Pro Asp His Leu Leu Gln Ile Cys His
65                  70                  75                  80  
Arg Leu Gly Pro Leu Leu Glu Gln Glu Ile Pro Gln Ser Val Pro Gly
                85                  90                  95      
Val Gln Thr Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu Arg Thr Asn
            100                 105                 110         
Lys Ser Cys Lys His Val Val Trp Lys Gly Ser Ala Leu Ala Ala Leu
        115                 120                 125             
His Cys Gly Arg Pro Pro Glu Ser Pro Val Asn Tyr Gly Ser Pro Pro
    130                 135                 140                 
Ser Ile Ala Asp Thr Leu Phe Ser Arg Lys Leu Asn Gly Lys Tyr Arg
145                 150                 155                 160 
Leu Glu Arg Leu Val Pro Thr Ala Val Tyr Gln His Met Lys Met His
                165                 170                 175     
Lys Arg Ile Leu Gly His Leu Ser Ser Val Tyr Cys Val Thr Phe Asp
            180                 185                 190         
Arg Thr Gly Arg Arg Ile Phe Thr Gly Ser Asp Asp Cys Leu Val Lys
        195                 200                 205             
Ile Trp Ala Thr Asp Asp Gly Arg Leu Leu Ala Thr Leu Arg Gly His
    210                 215                 220                 
Ala Ala Glu Ile Ser Asp Met Ala Val Asn Tyr Glu Asn Thr Met Ile
225                 230                 235                 240 
Ala Ala Gly Ser Cys Asp Lys Met Ile Arg Val Trp Cys Leu Arg Thr
                245                 250                 255     
Cys Ala Pro Leu Ala Val Leu Gln Gly His Ser Ala Ser Ile Thr Ser
            260                 265                 270         
Leu Gln Phe Ser Pro Leu Cys Ser Gly Ser Lys Arg Tyr Leu Ser Ser
        275                 280                 285             
Thr Gly Ala Asp Gly Thr Ile Cys Phe Trp Leu Trp Asp Ala Gly Thr
    290                 295                 300                 
Leu Lys Ile Asn Pro Arg Pro Ala Lys Phe Thr Glu Arg Pro Arg Pro
305                 310                 315                 320 
Gly Val Gln Met Ile Cys Ser Ser Phe Ser Ala Gly Gly Met Phe Leu
                325                 330                 335     
Ala Thr Gly Ser Thr Asp His Ile Ile Arg Val Tyr Phe Phe Gly Ser
            340                 345                 350         
Gly Gln Pro Glu Lys Ile Ser Glu Leu Glu Phe His Thr Asp Lys Val
        355                 360                 365             
Asp Ser Ile Gln Phe Ser Asn Thr Ser Asn Arg Phe Val Ser Gly Ser
    370                 375                 380                 
Arg Asp Gly Thr Ala Arg Ile Trp Gln Phe Lys Arg Arg Glu Trp Lys
385                 390                 395                 400 
Ser Ile Leu Leu Asp Met Ala Thr Arg Pro Ala Gly Gln Asn Leu Gln
                405                 410                 415     
Gly Ile Glu Asp Lys Ile Thr Lys Met Lys Val Thr Met Val Ala Trp
            420                 425                 430         
Asp Arg His Asp Asn Thr Val Ile Thr Ala Val Asn Asn Met Thr Leu
        435                 440                 445             
Lys Val Trp Asn Ser Tyr Thr Gly Gln Leu Ile His Val Leu Met Gly
    450                 455                 460                 
His Glu Asp Glu Val Phe Val Leu Glu Pro His Pro Phe Asp Pro Arg
465                 470                 475                 480 
Val Leu Phe Ser Ala Gly His Asp Gly Asn Val Ile Val Trp Asp Leu
                485                 490                 495     
Ala Arg Gly Val Lys Ile Arg Ser Tyr Phe Asn Met Ile Glu Gly Gln
            500                 505                 510         
Gly His Gly Ala Val Phe Asp Cys Lys Cys Ser Pro Asp Gly Gln His
        515                 520                 525             
Phe Ala Cys Thr Asp Ser His Gly His Leu Leu Ile Phe Gly Phe Gly
    530                 535                 540                 
Ser Ser Ser Lys Tyr Asp Lys Ile Ala Asp Gln Met Phe Phe His Ser
545                 550                 555                 560 
Asp Tyr Arg Pro Leu Ile Arg Asp Ala Asn Asn Phe Val Leu Asp Glu
                565                 570                 575     
Gln Thr Gln Gln Ala Pro His Leu Met Pro Pro Pro Phe Leu Val Asp
            580                 585                 590         
Val Asp Gly Asn Pro His Pro Ser Arg Tyr Gln Arg Leu Val Pro Gly
        595                 600                 605             
Arg Glu Asn Cys Arg Glu Glu Gln Leu Ile Pro Gln Met Gly Val Thr
    610                 615                 620                 
Ser Ser Gly Leu Asn Gln Val Leu Ser Gln Gln Ala Asn Gln Glu Ile
625                 630                 635                 640 
Ser Pro Leu Asp Ser Met Ile Gln Arg Leu Gln Gln Glu Gln Asp Leu
                645                 650                 655     
Arg Arg Ser Gly Glu Ala Gly Ile Ser Asn Thr Ser Arg Leu Ser Arg
            660                 665                 670         
Gly Ser Ile Ser Ser Thr Ser Glu Val His Ser Pro Pro Asn Val Gly
        675                 680                 685             
Leu Arg Arg Ser Gly Gln Ile Glu Gly Val Arg Gln Met His Ser Asn
    690                 695                 700                 
Ala Pro Arg Ser Glu Ile Ala Thr Glu Arg Asp Leu Val Ala Trp Ser
705                 710                 715                 720 
Arg Arg Val Val Val Pro Glu Leu Ser Ala Gly Val Ala Ser Arg Gln
                725                 730                 735     
Glu Glu Trp Arg Thr Ala Lys Gly Glu Glu Glu Ile Lys Thr Tyr Arg
            740                 745                 750         
Ser Glu Glu Lys Arg Lys His Leu Thr Val Pro Lys Glu Asn Lys Ile
        755                 760                 765             
Pro Thr Val Ser Lys Asn His Ala His Glu His Phe Leu Asp Leu Gly
    770                 775                 780                 
Glu Ser Lys Lys Gln Gln Thr Asn Gln His Asn Tyr Arg Thr Arg Ser
785                 790                 795                 800 
Ala Leu Glu Glu Thr Pro Arg Pro Ser Glu Glu Ile Glu Asn Gly Ser
                805                 810                 815     
Ser Ser Ser Asp Glu Gly Glu Val Val Ala Val Ser Gly Gly Thr Ser
            820                 825                 830         
Glu Glu Glu Glu Arg Ala Trp His Ser Asp Gly Ser Ser Ser Asp Tyr
        835                 840                 845             
Ser Ser Asp Tyr Ser Asp Trp Thr Ala Asp Ala Gly Ile Asn Leu Gln
    850                 855                 860                 
Pro Pro Lys Lys Val Pro Lys Asn Lys Thr Lys Lys Ala Glu Ser Ser
865                 870                 875                 880 
Ser Asp Glu Glu Glu Glu Ser Glu Lys Gln Lys Gln Lys Gln Ile Lys
                885                 890                 895     
Lys Glu Lys Lys Lys Val Asn Glu Glu Lys Asp Gly Pro Ile Ser Pro
            900                 905                 910         
Lys Lys Lys Lys Pro Lys Glu Arg Lys Gln Lys Arg Leu Ala Val Gly
        915                 920                 925             
Glu Leu Thr Glu Asn Gly Leu Thr Leu Glu Glu Trp Leu Pro Ser Thr
    930                 935                 940                 
Trp Ile Thr Asp Thr Ile Pro Arg Arg Cys Pro Phe Val Pro Gln Met
945                 950                 955                 960 
Gly Asp Glu Val Tyr Tyr Phe Arg Gln Gly His Glu Ala Tyr Val Glu
                965                 970                 975     
Met Ala Arg Lys Asn Lys Ile Tyr Ser Ile Asn Pro Lys Lys Gln Pro
            980                 985                 990         
Trp His Lys Met Glu Leu Arg Glu Gln Glu Leu Met Lys Ile Val Gly
        995                 1000                1005            
Ile Lys Tyr Glu Val Gly Leu Pro Thr Leu Cys Cys Leu Lys Leu Ala
    1010                1015                1020                
Phe Leu Asp Pro Asp Thr Gly Lys Leu Thr Gly Gly Ser Phe Thr Met
1025                1030                1035                1040
Lys Tyr His Asp Met Pro Asp Val Ile Asp Phe Leu Val Leu Arg Gln
                1045                1050                1055    
Gln Phe Asp Asp Ala Lys Tyr Arg Arg Trp Asn Ile Gly Asp Arg Phe
            1060                1065                1070        
Arg Ser Val Ile Asp Asp Ala Trp Trp Phe Gly Thr Ile Glu Ser Gln
        1075                1080                1085            
Glu Pro Leu Gln Leu Glu Tyr Pro Asp Ser Leu Phe Gln Cys Tyr Asn
    1090                1095                1100                
Val Cys Trp Asp Asn Gly Asp Thr Glu Lys Met Ser Pro Trp Asp Met
1105                1110                1115                1120
Glu Leu Ile Pro Asn Asn Ala Val Phe Pro Glu Glu Leu Gly Thr Ser
                1125                1130                1135    
Val Pro Leu Thr Asp Gly Glu Cys Arg Ser Leu Ile Tyr Lys Pro Leu
            1140                1145                1150        
Asp Gly Glu Trp Gly Thr Asn Pro Arg Asp Glu Glu Cys Glu Arg Ile
        1155                1160                1165            
Val Ala Gly Ile Asn Gln Leu Met Thr Leu Asp Ile Ala Ser Ala Phe
    1170                1175                1180                
Val Ala Pro Val Asp Leu Gln Ala Tyr Pro Met Tyr Cys Thr Val Val
1185                1190                1195                1200
Ala Tyr Pro Thr Asp Leu Ser Thr Ile Lys Gln Arg Leu Glu Asn Arg
                1205                1210                1215    
Phe Tyr Arg Arg Val Ser Ser Leu Met Trp Glu Val Arg Tyr Ile Glu
            1220                1225                1230        
His Asn Thr Arg Thr Phe Asn Glu Pro Gly Ser Pro Ile Val Lys Ser
        1235                1240                1245            
Ala Lys Phe Val Thr Asp Leu Leu Leu His Phe Ile Lys Asp Gln Thr
    1250                1255                1260                
Cys Tyr Asn Ile Ile Pro Leu Tyr Asn Ser Met Lys Lys Lys Val Leu
1265                1270                1275                1280
Ser Asp Ser Glu Asp Glu Glu Lys Asp Ala Asp Val Pro Gly Thr Ser
                1285                1290                1295    
Thr Arg Lys Arg Lys Asp His Gln Pro Arg Arg Arg Leu Arg Asn Arg
            1300                1305                1310        
Ala Gln Ser Tyr Asp Ile Gln Ala Trp Lys Lys Gln Cys Glu Glu Leu
        1315                1320                1325            
Leu Asn Leu Ile Phe Gln Cys Glu Asp Ser Glu Pro Phe Arg Gln Pro
    1330                1335                1340                
Val Asp Leu Leu Glu Tyr Pro Asp Tyr Arg Asp Ile Ile Asp Thr Pro
1345                1350                1355                1360
Met Asp Phe Ala Thr Val Arg Glu Thr Leu Glu Ala Gly Asn Tyr Glu
                1365                1370                1375    
Ser Pro Met Glu Leu Cys Lys Asp Val Arg Leu Ile Phe Ser Asn Ser
            1380                1385                1390        
Lys Ala Tyr Thr Pro Ser Lys Arg Ser Arg Ile Tyr Ser Met Ser Leu
        1395                1400                1405            
Arg Leu Ser Ala Phe Phe Glu Glu His Ile Ser Ser Val Leu Ser Asp
    1410                1415                1420                
Tyr Lys Ser Ala Leu Arg Phe His Lys Arg Asn Thr Ile Thr Lys Arg
1425                1430                1435                1440
Arg Lys Lys Arg Asn Arg Ser Ser Ser Val Ser Ser Ser Ala Ala Ser
                1445                1450                1455    
Ser Pro Glu Arg Lys Lys Arg Ile Leu Lys Pro Gln Leu Lys Ser Glu
            1460                1465                1470        
Ser Ser Thr Ser Ala Phe Ser Thr Pro Thr Arg Ser Ile Pro Pro Arg
        1475                1480                1485            
His Asn Ala Ala Gln Ile Asn Gly Lys Thr Glu Ser Ser Ser Val Val
    1490                1495                1500                
Arg Thr Arg Ser Asn Arg Val Val Val Asp Pro Val Val Thr Glu Gln
1505                1510                1515                1520
Pro Ser Thr Ser Ser Ala Ala Lys Thr Phe Ile Thr Lys Ala Asn Ala
                1525                1530                1535    
Ser Ala Ile Pro Gly Lys Thr Ile Leu Glu Asn Ser Val Lys His Ser
            1540                1545                1550        
Lys Ala Leu Asn Thr Leu Ser Ser Pro Gly Gln Ser Ser Phe Ser His
        1555                1560                1565            
Gly Thr Arg Asn Asn Ser Ala Lys Glu Asn Met Glu Lys Glu Lys Pro
    1570                1575                1580                
Val Lys Arg Lys Met Lys Ser Ser Val Leu Pro Lys Ala Ser Thr Leu
1585                1590                1595                1600
Ser Lys Ser Ser Ala Val Ile Glu Gln Gly Asp Cys Lys Asn Asn Ala
                1605                1610                1615    
Leu Val Pro Gly Thr Ile Gln Val Asn Gly His Gly Gly Gln Pro Ser
            1620                1625                1630        
Lys Leu Val Lys Arg Gly Pro Gly Arg Lys Pro Lys Val Glu Val Asn
        1635                1640                1645            
Thr Asn Ser Gly Glu Ile Ile His Lys Lys Arg Gly Arg Lys Pro Lys
    1650                1655                1660                
Lys Leu Gln Tyr Ala Lys Pro Glu Asp Leu Glu Gln Asn Asn Val His
1665                1670                1675                1680
Pro Ile Arg Asp Glu Val Leu Pro Ser Ser Thr Cys Asn Phe Leu Ser
                1685                1690                1695    
Glu Thr Asn Asn Val Lys Glu Asp Leu Leu Gln Lys Lys Asn Arg Gly
            1700                1705                1710        
Gly Arg Lys Pro Lys Arg Lys Met Lys Thr Gln Lys Leu Asp Ala Asp
        1715                1720                1725            
Leu Leu Val Pro Ala Ser Val Lys Val Leu Arg Arg Ser Asn Arg Lys
    1730                1735                1740                
Lys Ile Asp Asp Pro Ile Asp Glu Glu Glu Glu Phe Glu Glu Leu Lys
1745                1750                1755                1760
Gly Ser Glu Pro His Met Arg Thr Arg Asn Gln Gly Arg Arg Thr Ala
                1765                1770                1775    
Phe Tyr Asn Glu Asp Asp Ser Glu Glu Glu Gln Arg Gln Leu Leu Phe
            1780                1785                1790        
Glu Asp Thr Ser Leu Thr Phe Gly Thr Ser Ser Arg Gly Arg Val Arg
        1795                1800                1805            
Lys Leu Thr Glu Lys Ala Lys Ala Asn Leu Ile Gly Trp
    1810                1815                1820    


<210> 8224
<211> 341
<212> PRT
<213> Homo sapiens

<400> 8224
Met Met Cys Asp Pro Leu Asp Gln Leu Ala Thr Arg Thr Gln Lys Lys
 1               5                  10                  15      
Lys Ser Ala Thr Ser Lys Pro Pro Tyr Ser Phe Ser Leu Leu Ile Tyr
            20                  25                  30          
Met Ala Ile Glu His Ser Pro Asn Lys Cys Leu Pro Val Lys Glu Ile
        35                  40                  45              
Tyr Ser Trp Ile Leu Asp His Phe Pro Tyr Phe Ala Thr Ala Pro Thr
    50                  55                  60                  
Gly Trp Lys Asn Ser Val Arg His Asn Leu Ser Leu Asn Lys Cys Phe
65                  70                  75                  80  
Gln Lys Val Glu Arg Ser His Gly Lys Val Asn Gly Lys Gly Ser Leu
                85                  90                  95      
Trp Cys Val Asp Pro Glu Tyr Lys Pro Asn Leu Ile Gln Ala Leu Lys
            100                 105                 110         
Lys Gln Pro Phe Ser Ser Ala Ser Ser Gln Asn Gly Ser Leu Ser Pro
        115                 120                 125             
His Tyr Leu Ser Ser Val Ile Lys Gln Asn Gln Val Arg Asn Leu Lys
    130                 135                 140                 
Glu Ser Asp Ile Asp Ala Ala Ala Ala Met Met Leu Leu Asn Thr Ser
145                 150                 155                 160 
Ile Glu Gln Gly Ile Leu Glu Cys Glu Lys Pro Leu Pro Leu Lys Thr
                165                 170                 175     
Ala Leu Gln Lys Lys Arg Ser Tyr Gly Asn Ala Phe His His Pro Ser
            180                 185                 190         
Ala Val Arg Leu Gln Glu Ser Asp Ser Leu Ala Thr Ser Ile Asp Pro
        195                 200                 205             
Lys Glu Asp His Asn Tyr Ser Ala Ser Ser Met Ala Ala Gln Arg Cys
    210                 215                 220                 
Ala Ser Arg Ser Ser Val Ser Ser Leu Ser Ser Val Asp Glu Val Tyr
225                 230                 235                 240 
Glu Phe Ile Pro Lys Asn Ser His Val Gly Ser Asp Gly Ser Glu Gly
                245                 250                 255     
Phe His Ser Glu Glu Asp Thr Asp Val Asp Tyr Glu Asp Asp Pro Leu
            260                 265                 270         
Gly Asp Ser Gly Tyr Ala Ser Gln Pro Cys Ala Lys Ile Ser Glu Lys
        275                 280                 285             
Gly Gln Ser Gly Lys Lys Met Arg Lys Gln Thr Cys Gln Glu Ile Asp
    290                 295                 300                 
Glu Glu Leu Lys Glu Ala Ala Gly Ser Leu Leu His Leu Ala Gly Ile
305                 310                 315                 320 
Arg Thr Cys Leu Gly Ser Leu Ile Ser Thr Ala Lys Thr Gln Asn Gln
                325                 330                 335     
Lys Gln Arg Lys Lys
            340     


<210> 8225
<211> 407
<212> PRT
<213> Homo sapiens

<400> 8225
Met Leu Leu Ser Val Thr Ser Arg Pro Gly Ile Ser Thr Phe Gly Tyr
 1               5                  10                  15      
Asn Arg Asn Asn Lys Lys Pro Tyr Val Ser Leu Ala Gln Gln Met Ala
            20                  25                  30          
Pro Pro Ser Pro Ser Asn Ser Thr Pro Asn Ser Ser Ser Gly Ser Asn
        35                  40                  45              
Gly Asn Asp Gln Leu Ser Lys Thr Asn Leu Tyr Ile Arg Gly Leu Gln
    50                  55                  60                  
Pro Gly Thr Thr Asp Gln Asp Leu Val Lys Leu Cys Gln Pro Tyr Gly
65                  70                  75                  80  
Lys Ile Val Ser Thr Lys Ala Ile Leu Asp Lys Thr Thr Asn Lys Cys
                85                  90                  95      
Lys Gly Tyr Gly Phe Val Asp Phe Asp Ser Pro Ser Ala Ala Gln Lys
            100                 105                 110         
Ala Val Thr Ala Leu Lys Ala Ser Gly Val Gln Ala Gln Met Ala Lys
        115                 120                 125             
Gln Gln Glu Gln Asp Pro Thr Asn Leu Tyr Ile Ser Asn Leu Pro Leu
    130                 135                 140                 
Ser Met Asp Glu Gln Glu Leu Glu Gly Met Leu Lys Pro Phe Gly Gln
145                 150                 155                 160 
Val Ile Ser Thr Arg Ile Leu Arg Asp Thr Ser Gly Thr Ser Arg Gly
                165                 170                 175     
Val Gly Phe Ala Arg Met Glu Ser Thr Glu Lys Cys Glu Ala Ile Ile
            180                 185                 190         
Thr His Phe Asn Gly Lys Tyr Ile Lys Thr Pro Pro Gly Val Pro Ala
        195                 200                 205             
Pro Ser Asp Pro Leu Leu Cys Lys Phe Ala Asp Gly Gly Pro Lys Lys
    210                 215                 220                 
Arg Gln Asn Gln Gly Lys Phe Val Gln Asn Gly Arg Ala Trp Pro Arg
225                 230                 235                 240 
Asn Ala Asp Met Gly Val Met Ala Leu Thr Tyr Asp Pro Thr Thr Ala
                245                 250                 255     
Leu Gln Asn Gly Phe Tyr Pro Ala Pro Tyr Asn Ile Thr Pro Asn Arg
            260                 265                 270         
Met Leu Ala Gln Ser Ala Leu Ser Pro Tyr Leu Ser Ser Pro Val Ser
        275                 280                 285             
Ser Tyr Gln Arg Val Thr Gln Thr Ser Pro Leu Gln Val Pro Asn Pro
    290                 295                 300                 
Ser Trp Met His His His Ser Tyr Leu Met Gln Pro Ser Gly Ser Val
305                 310                 315                 320 
Leu Thr Pro Gly Met Asp His Pro Ile Ser Leu Gln Pro Ala Ser Met
                325                 330                 335     
Met Gly Pro Leu Thr Gln Gln Leu Gly His Leu Ser Leu Ser Ser Thr
            340                 345                 350         
Gly Thr Tyr Met Pro Thr Ala Ala Ala Met Gln Gly Ala Tyr Ile Ser
        355                 360                 365             
Gln Tyr Thr Pro Val Pro Ser Ser Ser Val Ser Val Glu Glu Ser Ser
    370                 375                 380                 
Gly Gln Gln Asn Gln Val Ala Val Asp Ala Pro Ser Glu His Gly Val
385                 390                 395                 400 
Tyr Ser Phe Gln Phe Asn Lys
                405         


<210> 8226
<211> 439
<212> PRT
<213> Homo sapiens

<400> 8226
Met Ser Lys Thr Met Ala Met Asn Leu Leu Glu Asp Trp Cys Arg Gly
 1               5                  10                  15      
Met Glu Val Asp Ile His Arg Ser Leu Leu Val Thr Gly Ile Pro Glu
            20                  25                  30          
Asp Cys Gly Gln Ala Glu Ile Glu Glu Thr Leu Asn Gly Val Leu Ser
        35                  40                  45              
Pro Leu Gly Pro Tyr Arg Val Leu Asn Lys Ile Phe Val Arg Glu Glu
    50                  55                  60                  
Asn Val Lys Ala Ala Leu Ile Glu Val Gly Glu Gly Val Asn Leu Ser
65                  70                  75                  80  
Thr Ile Pro Arg Glu Phe Pro Gly Arg Gly Gly Val Trp Arg Val Val
                85                  90                  95      
Cys Arg Asp Pro Thr Gln Asp Ala Glu Phe Leu Lys Asn Leu Asn Glu
            100                 105                 110         
Phe Leu Asp Ala Glu Gly Arg Thr Trp Glu Asp Val Val Arg Leu Leu
        115                 120                 125             
Gln Leu Asn His Pro Thr Leu Ser Gln Asn Gln His Gln Pro Pro Glu
    130                 135                 140                 
Asn Trp Ala Glu Ala Leu Gly Val Leu Leu Gly Ala Val Val Gln Ile
145                 150                 155                 160 
Ile Phe Cys Met Asp Ala Glu Ile Arg Ser Arg Glu Glu Ala Arg Ala
                165                 170                 175     
Gln Glu Ala Ala Glu Phe Glu Glu Met Ala Ala Trp Ala Leu Ala Ala
            180                 185                 190         
Gly Arg Lys Val Lys Lys Glu Pro Gly Leu Ala Ala Glu Val Gly Ser
        195                 200                 205             
Ala Leu Lys Ala Glu Thr Pro Asn Asn Trp Asn Ala Thr Glu Asp Gln
    210                 215                 220                 
His Glu Pro Thr Lys Pro Leu Val Arg Arg Ala Gly Ala Lys Ser Arg
225                 230                 235                 240 
Ser Arg Arg Lys Lys Gln Lys Lys Asn Ser Arg Gln Glu Ala Val Pro
                245                 250                 255     
Trp Lys Lys Pro Lys Gly Ile Asn Ser Asn Ser Thr Ala Asn Leu Glu
            260                 265                 270         
Asp Pro Glu Val Gly Asp Ala Glu Ser Met Ala Ile Ser Glu Pro Ile
        275                 280                 285             
Lys Gly Ser Arg Lys Pro Cys Val Asn Lys Glu Glu Leu Ala Leu Lys
    290                 295                 300                 
Lys Pro Met Ala Lys Cys Ala Trp Lys Gly Pro Arg Glu Pro Pro Gln
305                 310                 315                 320 
Asp Ala Arg Ala Glu Ala Glu Ser Pro Gly Gly Ala Ser Glu Ser Asp
                325                 330                 335     
Gln Asp Gly Gly His Glu Ser Pro Pro Lys Lys Lys Ala Val Ala Trp
            340                 345                 350         
Val Ser Ala Lys Asn Pro Ala Pro Met Arg Lys Lys Lys Lys Val Ser
        355                 360                 365             
Leu Gly Pro Val Ser Tyr Val Leu Val Asp Ser Glu Asp Gly Arg Lys
    370                 375                 380                 
Lys Pro Val Met Pro Lys Lys Gly Pro Gly Ser Arg Arg Glu Ala Ser
385                 390                 395                 400 
Asp Gln Lys Ala Pro Arg Gly Gln Gln Pro Ala Glu Ala Thr Ala Ser
                405                 410                 415     
Thr Ser Arg Gly Pro Lys Ala Lys Pro Glu Gly Ser Pro Arg Arg Ala
            420                 425                 430         
Thr Asn Glu Ser Arg Lys Val
        435                 


<210> 8227
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8227
Met Ala Ser Ala Ala Thr Asp Lys Thr Val Ser Lys Met Thr Tyr Arg
 1               5                  10                  15      
Lys Ser Ser Thr Cys Gly Asn Gly Ile Leu Glu Pro Thr Glu Gln Cys
            20                  25                  30          
Asp Cys Gly Tyr Lys Glu Ala Thr Asn Ser Phe Lys Phe Leu Asp Thr
        35                  40                  45              
Leu Thr Ser Asp Ser Leu Gly Asn Ile Pro Ile Leu Thr Tyr Gln Lys
    50                  55                  60                  
Lys Asn Thr Phe Asn Phe Thr Leu Ile Ser Trp His Ser Gly Leu Lys
65                  70                  75                  80  
Asp Arg Thr Leu Leu His Arg Val Thr Gly Leu Ser Pro Ser Gly Asp
                85                  90                  95      
Thr Lys Leu Pro Trp His Thr Asn Gln Pro Gly Val Gln Gly Leu Arg
            100                 105                 110         
Val Gln Ala Ala Gly Phe Glu Thr Ser
        115                 120     


<210> 8228
<211> 593
<212> PRT
<213> Homo sapiens

<400> 8228
Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala
 1               5                  10                  15      
Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg
            20                  25                  30          
Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn
        35                  40                  45              
Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp
    50                  55                  60                  
Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr
65                  70                  75                  80  
Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile
                85                  90                  95      
Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp
            100                 105                 110         
Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu
        115                 120                 125             
Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro
    130                 135                 140                 
Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser
145                 150                 155                 160 
Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu
                165                 170                 175     
Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp
            180                 185                 190         
Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr
        195                 200                 205             
Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala
    210                 215                 220                 
Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr
225                 230                 235                 240 
Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln
                245                 250                 255     
Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu
            260                 265                 270         
Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr
        275                 280                 285             
Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr
    290                 295                 300                 
Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn
305                 310                 315                 320 
Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn
                325                 330                 335     
Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val
            340                 345                 350         
Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val
        355                 360                 365             
Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg
    370                 375                 380                 
Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu
385                 390                 395                 400 
Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Thr Glu Arg Thr Val Trp
                405                 410                 415     
Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro
            420                 425                 430         
Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser
        435                 440                 445             
Ile Met Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly
    450                 455                 460                 
Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg
465                 470                 475                 480 
Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met
                485                 490                 495     
Val Arg Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg
            500                 505                 510         
Phe Ile Tyr Met Ala Val Gln His Tyr Ile Glu Thr Leu Gln Arg Arg
        515                 520                 525             
Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gly His Glu Tyr Thr Asn
    530                 535                 540                 
Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gly Asp Gln Ser Pro Leu
545                 550                 555                 560 
Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Glu Met Arg Glu Asp Ser
                565                 570                 575     
Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gln Gln Gln Lys Ser Phe
            580                 585                 590         
Arg
    


<210> 8229
<211> 176
<212> PRT
<213> Homo sapiens

<400> 8229
Gly Asp Glu Asp Gly Tyr Leu Ser Glu Gly Ile Val Arg Thr Asp Glu
 1               5                  10                  15      
Glu Glu Glu Glu Glu Gln Asp Ala Ser Ser Asn Asp Asn Phe Ser Val
            20                  25                  30          
Cys Pro Ser Asn Ser Val Asn His Asn Ser Tyr Asn Gly Lys Glu Thr
        35                  40                  45              
Lys Asn Arg Trp Lys Asn Asn Cys Pro Phe Ser Ala Asp Glu Asn Tyr
    50                  55                  60                  
Arg Pro Leu Ala Lys Thr Arg Gln Gln Asn Ile Ser Met Gln Arg Gln
65                  70                  75                  80  
Glu Asn Leu Arg Trp Val Ser Glu Leu Ser Tyr Val Glu Glu Lys Glu
                85                  90                  95      
Gln Trp Gln Glu Gln Ile Asn Gln Leu Lys Lys Gln Leu Asp Phe Ser
            100                 105                 110         
Val Ser Ile Cys Gln Thr Leu Lys Lys Ala Leu Trp Met Ser Arg Leu
        115                 120                 125             
Pro Ser Arg Leu Thr Leu Arg Leu Leu Lys Lys Met Asn Met Met Asn
    130                 135                 140                 
Arg Ser Tyr Asn Val Thr Leu Lys Arg Gln Gln Lys Ala Lys Met Ser
145                 150                 155                 160 
His Trp Asn Glu Lys Pro Leu Val Lys Met Thr Lys Ile Thr Val Leu
                165                 170                 175     


<210> 8230
<211> 428
<212> PRT
<213> Homo sapiens

<400> 8230
Gly Lys Ser Thr His Asn Glu Asp Gln Ala Ser Cys Glu Val Leu Thr
 1               5                  10                  15      
Val Lys Lys Lys Ala Gly Ala Val Thr Ser Thr Pro Asn Arg Asn Ser
            20                  25                  30          
Ser Lys Arg Arg Ser Ser Leu Pro Asn Gly Glu Gly Leu Gln Leu Lys
        35                  40                  45              
Glu Asn Ser Glu Ser Glu Gly Val Ser Cys His Tyr Trp Ser Leu Phe
    50                  55                  60                  
Asp Gly His Ala Gly Ser Gly Ala Ala Val Val Ala Ser Arg Leu Leu
65                  70                  75                  80  
Gln His His Ile Thr Glu Gln Leu Gln Asp Ile Val Asp Ile Leu Lys
                85                  90                  95      
Asn Ser Ala Val Leu Pro Pro Thr Cys Leu Gly Glu Glu Pro Glu Asn
            100                 105                 110         
Thr Pro Ala Asn Ser Arg Thr Leu Thr Arg Ala Ala Ser Leu Arg Gly
        115                 120                 125             
Gly Val Gly Ala Pro Gly Ser Pro Ser Thr Pro Pro Thr Arg Phe Phe
    130                 135                 140                 
Thr Glu Lys Lys Ile Pro His Glu Cys Leu Val Ile Gly Ala Leu Glu
145                 150                 155                 160 
Ser Ala Phe Lys Glu Met Asp Leu Gln Ile Glu Arg Glu Arg Ser Ser
                165                 170                 175     
Tyr Asn Ile Ser Gly Gly Cys Thr Ala Leu Ile Val Ile Cys Leu Leu
            180                 185                 190         
Gly Lys Leu Tyr Val Ala Asn Ala Gly Asp Ser Arg Ala Ile Ile Ile
        195                 200                 205             
Arg Asn Gly Glu Ile Ile Pro Met Ser Ser Glu Phe Thr Pro Glu Thr
    210                 215                 220                 
Glu Arg Gln Arg Leu Gln Tyr Leu Ala Phe Met Gln Pro His Leu Leu
225                 230                 235                 240 
Gly Asn Glu Phe Thr His Leu Glu Phe Pro Arg Arg Val Gln Arg Lys
                245                 250                 255     
Glu Leu Gly Lys Lys Met Leu Tyr Arg Asp Phe Asn Met Thr Gly Trp
            260                 265                 270         
Ala Tyr Lys Thr Ile Glu Asp Glu Asp Leu Lys Phe Pro Leu Ile Tyr
        275                 280                 285             
Gly Glu Gly Lys Lys Ala Arg Val Met Ala Thr Ile Gly Val Thr Arg
    290                 295                 300                 
Gly Leu Gly Asp His Asp Leu Lys Val His Asp Ser Asn Ile Tyr Ile
305                 310                 315                 320 
Lys Pro Phe Leu Ser Ser Ala Pro Glu Val Arg Ile Tyr Asp Leu Ser
                325                 330                 335     
Lys Tyr Asp His Gly Ser Asp Asp Val Leu Ile Leu Ala Thr Asp Gly
            340                 345                 350         
Leu Trp Asp Val Leu Ser Asn Glu Glu Val Ala Glu Ala Ile Thr Gln
        355                 360                 365             
Phe Leu Pro Asn Cys Asp Pro Asp Asp Pro His Arg Tyr Thr Leu Ala
    370                 375                 380                 
Ala Gln Asp Leu Val Met Arg Ala Arg Gly Val Leu Lys Asp Arg Gly
385                 390                 395                 400 
Trp Arg Ile Ser Asn Asp Arg Leu Gly Ser Gly Asp Asp Ile Ser Val
                405                 410                 415     
Tyr Val Ile Pro Leu Ile His Gly Asn Lys Leu Ser
            420                 425             


<210> 8231
<211> 120
<212> PRT
<213> Homo sapiens

<400> 8231
Met Thr Thr Cys Glu Phe Glu Phe Ile Phe Leu Lys Glu Gln Val Thr
 1               5                  10                  15      
Arg Ile Cys Asn Ile Ala Pro Leu Lys Ala Tyr Phe Ser Val His Lys
            20                  25                  30          
Met Gly Lys Ile Leu Lys Lys Leu Ser Asn Phe Ser Phe Leu Thr His
        35                  40                  45              
Arg Gln Ser Leu Thr Leu Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile
    50                  55                  60                  
Ser Ala His Cys Asn Leu His Leu Leu Gly Ser Ser Asn Ser Ala Ala
65                  70                  75                  80  
Ser Ala Ser Arg Val Ala Gly Thr Thr Gly Ala Cys His His Ala Gln
                85                  90                  95      
Leu Ile Phe Val Phe Leu Val Glu Thr Gly Phe His His Val Gly Gln
            100                 105                 110         
Asp Gly Leu Gly Leu Leu Thr Ser
        115                 120 


<210> 8232
<211> 980
<212> PRT
<213> Homo sapiens

<400> 8232
Met Thr Ser Pro Gln Leu Glu Trp Thr Leu Gln Thr Leu Leu Glu Gln
 1               5                  10                  15      
Leu Asn Glu Asp Glu Leu Lys Ser Phe Lys Ser Leu Leu Trp Ala Phe
            20                  25                  30          
Pro Leu Glu Asp Val Leu Gln Lys Thr Pro Trp Ser Glu Val Glu Glu
        35                  40                  45              
Ala Asp Gly Lys Lys Leu Ala Glu Ile Leu Val Asn Thr Ser Ser Glu
    50                  55                  60                  
Asn Trp Ile Arg Asn Ala Thr Val Asn Ile Leu Glu Glu Met Asn Leu
65                  70                  75                  80  
Thr Glu Leu Cys Lys Met Ala Lys Ala Glu Met Met Glu Asp Gly Gln
                85                  90                  95      
Val Gln Glu Ile Asp Asn Pro Glu Leu Gly Asp Ala Glu Glu Asp Ser
            100                 105                 110         
Glu Leu Ala Lys Pro Gly Glu Lys Glu Gly Trp Arg Asn Ser Met Glu
        115                 120                 125             
Lys Gln Ser Leu Val Trp Lys Asn Thr Phe Trp Gln Gly Asp Ile Asp
    130                 135                 140                 
Asn Phe His Asp Asp Val Thr Leu Arg Asn Gln Arg Phe Ile Pro Phe
145                 150                 155                 160 
Leu Asn Pro Arg Thr Pro Arg Lys Leu Thr Pro Tyr Thr Val Val Leu
                165                 170                 175     
His Gly Pro Ala Gly Val Gly Lys Thr Thr Leu Ala Lys Lys Cys Met
            180                 185                 190         
Leu Asp Trp Thr Asp Cys Asn Leu Ser Pro Thr Leu Arg Tyr Ala Phe
        195                 200                 205             
Tyr Leu Ser Cys Lys Glu Leu Ser Arg Met Gly Pro Cys Ser Phe Ala
    210                 215                 220                 
Glu Leu Ile Ser Lys Asp Trp Pro Glu Leu Gln Asp Asp Ile Pro Ser
225                 230                 235                 240 
Ile Leu Ala Gln Ala Gln Arg Ile Leu Phe Val Val Asp Gly Leu Asp
                245                 250                 255     
Glu Leu Lys Val Pro Pro Gly Ala Leu Ile Gln Asp Ile Cys Gly Asp
            260                 265                 270         
Trp Glu Lys Lys Lys Pro Val Pro Val Leu Leu Gly Ser Leu Leu Lys
        275                 280                 285             
Arg Lys Met Leu Pro Arg Ala Ala Leu Leu Val Thr Thr Arg Pro Arg
    290                 295                 300                 
Ala Leu Arg Asp Leu Gln Leu Leu Ala Gln Gln Pro Ile Tyr Val Arg
305                 310                 315                 320 
Val Glu Gly Phe Leu Glu Glu Asp Arg Arg Ala Tyr Phe Leu Arg His
                325                 330                 335     
Phe Gly Asp Glu Asp Gln Ala Met Arg Ala Phe Glu Leu Met Arg Ser
            340                 345                 350         
Asn Ala Ala Leu Phe Gln Leu Gly Ser Ala Pro Ala Val Cys Trp Ile
        355                 360                 365             
Val Cys Thr Thr Leu Lys Leu Gln Met Glu Lys Gly Glu Asp Pro Val
    370                 375                 380                 
Pro Thr Cys Leu Thr Arg Thr Gly Leu Phe Leu Arg Phe Leu Cys Ser
385                 390                 395                 400 
Arg Phe Pro Gln Gly Ala Gln Leu Arg Gly Ala Leu Arg Thr Leu Ser
                405                 410                 415     
Leu Leu Ala Ala Gln Gly Leu Trp Ala Gln Met Ser Val Phe His Arg
            420                 425                 430         
Glu Asp Leu Glu Arg Leu Gly Val Gln Glu Ser Asp Leu Arg Leu Phe
        435                 440                 445             
Leu Asp Gly Asp Ile Leu Arg Gln Asp Arg Val Ser Lys Gly Cys Tyr
    450                 455                 460                 
Ser Phe Ile His Leu Ser Phe Gln Gln Phe Leu Thr Ala Leu Phe Tyr
465                 470                 475                 480 
Ala Leu Glu Lys Glu Glu Gly Glu Asp Arg Asp Gly His Ala Trp Asp
                485                 490                 495     
Ile Gly Asp Val Gln Lys Leu Leu Ser Gly Glu Glu Arg Leu Lys Asn
            500                 505                 510         
Pro Asp Leu Ile Gln Val Gly His Phe Leu Phe Gly Leu Ala Asn Glu
        515                 520                 525             
Lys Arg Ala Lys Glu Leu Glu Ala Thr Phe Gly Cys Arg Met Ser Pro
    530                 535                 540                 
Asp Ile Lys Gln Glu Leu Leu Gln Cys Lys Ala His Leu His Ala Asn
545                 550                 555                 560 
Lys Pro Leu Ser Val Thr Asp Leu Lys Glu Val Leu Gly Cys Leu Tyr
                565                 570                 575     
Glu Ser Gln Glu Glu Glu Leu Ala Lys Val Val Val Ala Pro Phe Lys
            580                 585                 590         
Glu Ile Ser Ile His Leu Thr Asn Thr Ser Glu Val Met His Cys Ser
        595                 600                 605             
Phe Ser Leu Lys His Cys Gln Asp Leu Gln Lys Leu Ser Leu Gln Val
    610                 615                 620                 
Ala Lys Gly Val Phe Leu Glu Asn Tyr Met Asp Phe Glu Leu Asp Ile
625                 630                 635                 640 
Glu Phe Glu Arg Cys Thr Tyr Leu Thr Ile Pro Asn Trp Ala Arg Gln
                645                 650                 655     
Asp Leu Arg Ser Leu Arg Leu Trp Thr Asp Phe Cys Ser Leu Phe Ser
            660                 665                 670         
Ser Asn Ser Asn Leu Lys Phe Leu Glu Val Lys Gln Ser Phe Leu Ser
        675                 680                 685             
Asp Ser Ser Val Arg Ile Leu Cys Asp His Val Thr Arg Ser Thr Cys
    690                 695                 700                 
His Leu Gln Lys Val Glu Ile Lys Asn Val Thr Pro Asp Thr Ala Tyr
705                 710                 715                 720 
Arg Asp Phe Cys Leu Ala Phe Ile Gly Lys Lys Thr Leu Thr His Leu
                725                 730                 735     
Thr Leu Ala Gly His Ile Glu Trp Glu Arg Thr Met Met Leu Met Leu
            740                 745                 750         
Cys Asp Leu Leu Arg Asn His Lys Cys Asn Leu Gln Tyr Leu Arg Leu
        755                 760                 765             
Gly Gly His Cys Ala Thr Pro Glu Gln Trp Ala Glu Phe Phe Tyr Val
    770                 775                 780                 
Leu Lys Ala Asn Gln Ser Leu Lys His Leu Arg Leu Ser Ala Asn Val
785                 790                 795                 800 
Leu Leu Asp Glu Gly Ala Met Leu Leu Tyr Lys Thr Met Thr Arg Pro
                805                 810                 815     
Lys His Phe Leu Gln Met Leu Ser Leu Glu Asn Cys Arg Leu Thr Glu
            820                 825                 830         
Ala Ser Cys Lys Asp Leu Ala Ala Val Leu Val Val Ser Lys Lys Leu
        835                 840                 845             
Thr His Leu Cys Leu Ala Lys Asn Pro Ile Gly Asp Thr Gly Val Lys
    850                 855                 860                 
Phe Leu Cys Glu Gly Leu Ser Tyr Pro Asp Cys Lys Leu Gln Thr Leu
865                 870                 875                 880 
Val Leu Gln Gln Cys Ser Ile Thr Lys Leu Gly Cys Arg Tyr Leu Ser
                885                 890                 895     
Glu Ala Leu Gln Glu Ala Cys Ser Leu Thr Asn Leu Asp Leu Ser Ile
            900                 905                 910         
Asn Gln Ile Ala Arg Gly Leu Trp Ile Leu Cys Gln Ala Leu Glu Asn
        915                 920                 925             
Pro Asn Cys Asn Leu Lys His Leu Arg Leu Lys Thr Tyr Glu Thr Asn
    930                 935                 940                 
Leu Glu Ile Lys Lys Leu Leu Glu Glu Val Lys Glu Lys Asn Pro Lys
945                 950                 955                 960 
Leu Thr Ile Asp Cys Asn Ala Ser Gly Ala Thr Ala Pro Pro Cys Cys
                965                 970                 975     
Asp Phe Phe Cys
            980 


<210> 8233
<211> 393
<212> PRT
<213> Homo sapiens

<400> 8233
Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp
 1               5                  10                  15      
Gly Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala
            20                  25                  30          
Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys
        35                  40                  45              
Arg Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys
    50                  55                  60                  
Asp Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly
65                  70                  75                  80  
Val Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg
                85                  90                  95      
Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile
            100                 105                 110         
Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly
        115                 120                 125             
Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu
    130                 135                 140                 
His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg
145                 150                 155                 160 
Ile Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly
                165                 170                 175     
Leu Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys
            180                 185                 190         
Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp
        195                 200                 205             
Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val
    210                 215                 220                 
Gly Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr
225                 230                 235                 240 
Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met
                245                 250                 255     
Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu
            260                 265                 270         
Leu Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro
        275                 280                 285             
Arg Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser
    290                 295                 300                 
Arg Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu
305                 310                 315                 320 
Pro Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp
                325                 330                 335     
Phe Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu
            340                 345                 350         
Lys Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu
        355                 360                 365             
Val Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro
    370                 375                 380                 
Ser Thr Pro Thr His Ala Ala Gly Val
385                 390             


<210> 8234
<211> 257
<212> PRT
<213> Homo sapiens

<400> 8234
Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu
 1               5                  10                  15      
Glu Ala Gln Glu Glu Glu Glu Val Gln Glu Asp Thr Ala Glu Glu Asp
            20                  25                  30          
Ala Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala Pro Lys Ile Pro
        35                  40                  45              
Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys Lys Arg Gln Asn
    50                  55                  60                  
Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser His Phe Glu Ala
65                  70                  75                  80  
Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys Glu Arg Ile Glu
                85                  90                  95      
Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg Ala Glu Lys
            100                 105                 110         
Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys Ala Arg Arg Glu
        115                 120                 125             
Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu Lys Lys Lys Lys
    130                 135                 140                 
Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr Leu Ala Lys Ala
145                 150                 155                 160 
Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu Met Lys Lys Lys
                165                 170                 175     
Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp His Leu Gly Glu
            180                 185                 190         
Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu Thr Leu His Gln
        195                 200                 205             
Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu Lys Arg Gln Lys
    210                 215                 220                 
Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln Ala Gln Lys His
225                 230                 235                 240 
Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val Gly Gly Arg Trp
                245                 250                 255     
Lys
    


<210> 8235
<211> 260
<212> PRT
<213> Homo sapiens

<400> 8235
Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu
 1               5                  10                  15      
Glu Ala Gln Glu Glu Ala Ala Glu Val His Glu Glu Val His Glu Pro
            20                  25                  30          
Glu Glu Val Gln Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala Pro
        35                  40                  45              
Lys Ile Pro Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys Lys
    50                  55                  60                  
Arg Gln Asn Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser His
65                  70                  75                  80  
Phe Glu Ala Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys Glu
                85                  90                  95      
Arg Ile Glu Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg
            100                 105                 110         
Ala Glu Lys Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys Ala
        115                 120                 125             
Arg Arg Glu Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu Lys
    130                 135                 140                 
Lys Lys Lys Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr Leu
145                 150                 155                 160 
Ala Lys Ala Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu Met
                165                 170                 175     
Lys Lys Lys Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp His
            180                 185                 190         
Leu Gly Glu Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu Thr
        195                 200                 205             
Leu His Gln Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu Lys
    210                 215                 220                 
Arg Gln Lys Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln Ala
225                 230                 235                 240 
Gln Lys His Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val Gly
                245                 250                 255     
Gly Arg Trp Lys
            260 


<210> 8236
<211> 268
<212> PRT
<213> Homo sapiens

<400> 8236
Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu
 1               5                  10                  15      
Glu Ala Gln Glu Glu Ala Ala Glu Val His Glu Glu Val His Glu Pro
            20                  25                  30          
Glu Glu Val Gln Glu Asp Thr Ala Glu Glu Asp Ala Glu Glu Glu Lys
        35                  40                  45              
Pro Arg Pro Lys Leu Thr Ala Pro Lys Ile Pro Glu Gly Glu Lys Val
    50                  55                  60                  
Asp Phe Asp Asp Ile Gln Lys Lys Arg Gln Asn Lys Asp Leu Met Glu
65                  70                  75                  80  
Leu Gln Ala Leu Ile Asp Ser His Phe Glu Ala Arg Lys Lys Glu Glu
                85                  90                  95      
Glu Glu Leu Val Ala Leu Lys Glu Arg Ile Glu Lys Arg Arg Ala Glu
            100                 105                 110         
Arg Ala Glu Gln Gln Arg Ile Arg Ala Glu Lys Glu Arg Glu Arg Gln
        115                 120                 125             
Asn Arg Leu Ala Glu Glu Lys Ala Arg Arg Glu Glu Glu Asp Ala Lys
    130                 135                 140                 
Arg Arg Ala Glu Asp Asp Leu Lys Lys Lys Lys Ala Leu Ser Ser Met
145                 150                 155                 160 
Gly Ala Asn Tyr Ser Ser Tyr Leu Ala Lys Ala Asp Gln Lys Arg Gly
                165                 170                 175     
Lys Lys Gln Thr Ala Arg Glu Met Lys Lys Lys Ile Leu Ala Glu Arg
            180                 185                 190         
Arg Lys Pro Leu Asn Ile Asp His Leu Gly Glu Asp Lys Leu Arg Asp
        195                 200                 205             
Lys Ala Lys Glu Leu Trp Glu Thr Leu His Gln Leu Glu Ile Asp Lys
    210                 215                 220                 
Phe Glu Phe Gly Glu Lys Leu Lys Arg Gln Lys Tyr Asp Ile Thr Thr
225                 230                 235                 240 
Leu Arg Ser Arg Ile Asp Gln Ala Gln Lys His Ser Lys Lys Ala Gly
                245                 250                 255     
Thr Pro Ala Lys Gly Lys Val Gly Gly Arg Trp Lys
            260                 265             


<210> 8237
<211> 249
<212> PRT
<213> Homo sapiens

<400> 8237
Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu
 1               5                  10                  15      
Glu Ala Gln Glu Glu Glu Glu Val Gln Glu Glu Glu Lys Pro Arg Pro
            20                  25                  30          
Lys Leu Thr Ala Pro Lys Ile Pro Glu Gly Glu Lys Val Asp Phe Asp
        35                  40                  45              
Asp Ile Gln Lys Lys Arg Gln Asn Lys Asp Leu Met Glu Leu Gln Ala
    50                  55                  60                  
Leu Ile Asp Ser His Phe Glu Ala Arg Lys Lys Glu Glu Glu Glu Leu
65                  70                  75                  80  
Val Ala Leu Lys Glu Arg Ile Glu Lys Arg Arg Ala Glu Arg Ala Glu
                85                  90                  95      
Gln Gln Arg Ile Arg Ala Glu Lys Glu Arg Glu Arg Gln Asn Arg Leu
            100                 105                 110         
Ala Glu Glu Lys Ala Arg Arg Glu Glu Glu Asp Ala Lys Arg Arg Ala
        115                 120                 125             
Glu Asp Asp Leu Lys Lys Lys Lys Ala Leu Ser Ser Met Gly Ala Asn
    130                 135                 140                 
Tyr Ser Ser Tyr Leu Ala Lys Ala Asp Gln Lys Arg Gly Lys Lys Gln
145                 150                 155                 160 
Thr Ala Arg Glu Met Lys Lys Lys Ile Leu Ala Glu Arg Arg Lys Pro
                165                 170                 175     
Leu Asn Ile Asp His Leu Gly Glu Asp Lys Leu Arg Asp Lys Ala Lys
            180                 185                 190         
Glu Leu Trp Glu Thr Leu His Gln Leu Glu Ile Asp Lys Phe Glu Phe
        195                 200                 205             
Gly Glu Lys Leu Lys Arg Gln Lys Tyr Asp Ile Met Asn Val Arg Ala
    210                 215                 220                 
Arg Val Gln Met Leu Ala Lys Phe Ser Lys Lys Ala Gly Thr Pro Ala
225                 230                 235                 240 
Lys Gly Lys Val Gly Gly Arg Trp Lys
                245                 


<210> 8238
<211> 244
<212> PRT
<213> Homo sapiens

<400> 8238
Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu Glu
 1               5                  10                  15      
Glu Ala Gln Glu Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala Pro
            20                  25                  30          
Lys Ile Pro Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys Lys
        35                  40                  45              
Arg Gln Asn Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser His
    50                  55                  60                  
Phe Glu Ala Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys Glu
65                  70                  75                  80  
Arg Ile Glu Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg
                85                  90                  95      
Ala Glu Lys Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys Ala
            100                 105                 110         
Arg Arg Glu Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu Lys
        115                 120                 125             
Lys Lys Lys Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr Leu
    130                 135                 140                 
Ala Lys Ala Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu Met
145                 150                 155                 160 
Lys Lys Lys Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp His
                165                 170                 175     
Leu Gly Glu Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu Thr
            180                 185                 190         
Leu His Gln Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu Lys
        195                 200                 205             
Arg Gln Lys Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln Ala
    210                 215                 220                 
Gln Lys His Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val Gly
225                 230                 235                 240 
Gly Arg Trp Lys
                


<210> 8239
<211> 398
<212> PRT
<213> Homo sapiens

<400> 8239
Met Ser Val Ser Arg Thr Met Glu Asp Ser Cys Glu Leu Asp Leu Val
 1               5                  10                  15      
Tyr Val Thr Glu Arg Ile Ile Ala Val Ser Phe Pro Ser Thr Ala Asn
            20                  25                  30          
Glu Glu Asn Phe Arg Ser Asn Leu Ser Glu Arg Arg Pro Asp Ile Thr
        35                  40                  45              
Lys Leu His Ala Lys Val Gln Glu Phe Gly Trp Pro Asp Leu His Thr
    50                  55                  60                  
Pro Ala Leu Glu Lys Ile Cys Ser Ile Cys Lys Ala Met Asp Thr Trp
65                  70                  75                  80  
Leu Asn Ala Asp Pro His Asn Val Val Val Leu His Asn Lys Gly Asn
                85                  90                  95      
Arg Gly Arg Ile Gly Val Val Ile Ala Ala Tyr Met His Tyr Ser Asn
            100                 105                 110         
Ile Ser Ala Ser Ala Asp Gln Ala Leu Asp Arg Phe Ala Met Lys Arg
        115                 120                 125             
Phe Tyr Glu Asp Lys Ile Val Pro Ile Gly Gln Pro Ser Gln Arg Arg
    130                 135                 140                 
Tyr Val His Tyr Phe Ser Gly Leu Leu Ser Gly Ser Ile Lys Met Asn
145                 150                 155                 160 
Asn Lys Pro Leu Phe Leu His His Val Ile Met His Gly Ile Pro Asn
                165                 170                 175     
Phe Glu Ser Lys Gly Gly Cys Arg Pro Phe Leu Arg Ile Tyr Gln Ala
            180                 185                 190         
Met Gln Pro Val Tyr Thr Ser Gly Ile Tyr Asn Ile Pro Gly Asp Ser
        195                 200                 205             
Gln Thr Ser Val Cys Ile Thr Ile Glu Pro Gly Leu Leu Leu Lys Gly
    210                 215                 220                 
Asp Ile Leu Leu Lys Cys Tyr His Lys Lys Phe Arg Ser Pro Ala Arg
225                 230                 235                 240 
Asp Val Ile Phe Arg Val Gln Phe His Thr Cys Ala Ile His Asp Leu
                245                 250                 255     
Gly Val Val Phe Gly Lys Glu Asp Leu Asp Asp Ala Phe Lys Asp Asp
            260                 265                 270         
Arg Phe Pro Glu Tyr Gly Lys Val Glu Phe Val Phe Ser Tyr Gly Pro
        275                 280                 285             
Glu Lys Ile Gln Gly Met Glu His Leu Glu Asn Gly Pro Ser Val Ser
    290                 295                 300                 
Val Asp Tyr Asn Thr Ser Asp Pro Leu Ile Arg Trp Asp Ser Tyr Asp
305                 310                 315                 320 
Asn Phe Ser Gly His Arg Asp Asp Gly Met Glu Glu Val Val Gly His
                325                 330                 335     
Thr Gln Gly Pro Leu Asp Gly Ser Leu Tyr Ala Lys Val Lys Lys Lys
            340                 345                 350         
Asp Ser Leu His Gly Ser Thr Gly Ala Val Asn Ala Thr Arg Pro Thr
        355                 360                 365             
Leu Ser Ala Thr Pro Asn His Val Glu His Thr Leu Ser Val Tyr Leu
    370                 375                 380                 
Tyr Arg Trp Lys Tyr Thr Leu Tyr Phe Val Ser Ser Cys Leu
385                 390                 395             


<210> 8240
<211> 1735
<212> PRT
<213> Homo sapiens

<400> 8240
Met Ser Val Ser Arg Thr Met Glu Asp Ser Cys Glu Leu Asp Leu Val
 1               5                  10                  15      
Tyr Val Thr Glu Arg Ile Ile Ala Val Ser Phe Pro Ser Thr Ala Asn
            20                  25                  30          
Glu Glu Asn Phe Arg Ser Asn Leu Arg Glu Val Ala Gln Met Leu Lys
        35                  40                  45              
Ser Lys His Gly Gly Asn Tyr Leu Leu Phe Asn Leu Ser Glu Arg Arg
    50                  55                  60                  
Pro Asp Ile Thr Lys Leu His Ala Lys Val Leu Glu Phe Gly Trp Pro
65                  70                  75                  80  
Asp Leu His Thr Pro Ala Leu Glu Lys Ile Cys Ser Ile Cys Lys Ala
                85                  90                  95      
Met Asp Thr Trp Leu Asn Ala Asp Pro His Asn Val Val Val Leu His
            100                 105                 110         
Asn Lys Gly Asn Arg Gly Arg Ile Gly Val Val Ile Ala Ala Tyr Met
        115                 120                 125             
His Tyr Ser Asn Ile Ser Ala Ser Ala Asp Gln Ala Leu Asp Arg Phe
    130                 135                 140                 
Ala Met Lys Arg Phe Tyr Glu Asp Lys Ile Val Pro Ile Gly Gln Pro
145                 150                 155                 160 
Ser Gln Arg Arg Tyr Val His Tyr Phe Ser Gly Leu Leu Ser Gly Ser
                165                 170                 175     
Ile Lys Ile Asn Asn Lys Pro Leu Phe Leu His His Val Ile Met His
            180                 185                 190         
Gly Ile Pro Asn Phe Glu Ser Lys Gly Gly Cys Arg Pro Phe Leu Arg
        195                 200                 205             
Ile Tyr Gln Ala Met Gln Pro Val Tyr Thr Ser Gly Ile Tyr Asn Ile
    210                 215                 220                 
Pro Gly Asp Ser Gln Thr Ser Val Cys Ile Thr Ile Glu Pro Gly Leu
225                 230                 235                 240 
Leu Leu Lys Gly Asp Ile Leu Leu Lys Cys Tyr His Lys Lys Phe Arg
                245                 250                 255     
Ser Pro Ala Arg Asp Val Ile Phe Arg Val Gln Phe His Thr Cys Ala
            260                 265                 270         
Ile His Asp Leu Gly Val Val Phe Gly Lys Glu Asp Leu Asp Asp Ala
        275                 280                 285             
Phe Lys Asp Asp Arg Phe Pro Glu Tyr Gly Lys Val Glu Phe Val Phe
    290                 295                 300                 
Ser Tyr Gly Pro Glu Lys Ile Gln Gly Met Glu His Leu Glu Asn Gly
305                 310                 315                 320 
Pro Ser Val Ser Val Asp Tyr Asn Thr Ser Asp Pro Leu Ile Arg Trp
                325                 330                 335     
Asp Ser Tyr Asp Asn Phe Ser Gly His Arg Asp Asp Gly Met Glu Glu
            340                 345                 350         
Val Val Gly His Thr Gln Gly Pro Leu Asp Gly Ser Leu Tyr Ala Lys
        355                 360                 365             
Val Lys Lys Lys Asp Ser Leu His Gly Ser Thr Gly Ala Val Asn Ala
    370                 375                 380                 
Thr Arg Pro Thr Leu Ser Ala Thr Pro Asn His Val Glu His Thr Leu
385                 390                 395                 400 
Ser Val Ser Ser Asp Ser Gly Asn Ser Thr Ala Ser Thr Lys Thr Asp
                405                 410                 415     
Lys Thr Asp Glu Pro Val Pro Gly Ala Ser Ser Ala Thr Ala Ala Leu
            420                 425                 430         
Ser Pro Gln Glu Lys Arg Glu Leu Asp Arg Leu Leu Ser Gly Phe Gly
        435                 440                 445             
Leu Glu Arg Glu Lys Gln Gly Ala Met Tyr His Thr Gln His Leu Arg
    450                 455                 460                 
Ser Arg Pro Ala Gly Gly Ser Ala Val Pro Ser Ser Gly Arg His Val
465                 470                 475                 480 
Val Pro Ala Gln Val His Val Asn Gly Gly Ala Leu Ala Ser Glu Arg
                485                 490                 495     
Glu Thr Asp Ile Leu Asp Asp Glu Leu Pro Asn Gln Asp Gly His Ser
            500                 505                 510         
Ala Gly Ser Met Gly Thr Leu Ser Ser Leu Asp Gly Val Thr Asn Thr
        515                 520                 525             
Ser Glu Gly Gly Tyr Pro Glu Ala Leu Ser Pro Leu Thr Asn Gly Leu
    530                 535                 540                 
Asp Lys Ser Tyr Pro Met Glu Pro Met Val Asn Gly Gly Gly Tyr Pro
545                 550                 555                 560 
Tyr Glu Ser Ala Ser Arg Ala Gly Pro Ala His Ala Gly His Thr Ala
                565                 570                 575     
Pro Met Arg Pro Ser Tyr Ser Ala Gln Glu Gly Leu Ala Gly Tyr Gln
            580                 585                 590         
Arg Glu Gly Pro His Pro Ala Trp Pro Gln Pro Val Thr Thr Ser His
        595                 600                 605             
Tyr Ala His Asp Pro Ser Gly Met Phe Arg Ser Gln Ser Phe Ser Glu
    610                 615                 620                 
Ala Glu Pro Gln Leu Pro Pro Ala Pro Val Arg Gly Gly Ser Ser Arg
625                 630                 635                 640 
Glu Ala Val Gln Arg Gly Leu Asn Ser Trp Gln Gln Gln Gln Gln Gln
                645                 650                 655     
Gln Gln Gln Pro Arg Pro Pro Pro Arg Gln Gln Glu Arg Ala His Leu
            660                 665                 670         
Glu Ser Leu Val Ala Ser Arg Pro Ser Pro Gln Pro Leu Ala Glu Thr
        675                 680                 685             
Pro Ile Pro Ser Leu Pro Glu Phe Pro Arg Ala Ala Ser Gln Gln Glu
    690                 695                 700                 
Ile Glu Gln Ser Ile Glu Thr Leu Asn Met Leu Met Leu Asp Leu Glu
705                 710                 715                 720 
Pro Ala Ser Ala Ala Ala Pro Leu His Lys Ser Gln Ser Val Pro Gly
                725                 730                 735     
Ala Trp Pro Gly Ala Ser Pro Leu Ser Ser Gln Pro Leu Ser Gly Ser
            740                 745                 750         
Ser Arg Gln Ser His Pro Leu Thr Gln Ser Arg Ser Gly Tyr Ile Pro
        755                 760                 765             
Ser Gly His Ser Leu Gly Thr Pro Glu Pro Ala Pro Arg Ala Ser Leu
    770                 775                 780                 
Glu Ser Val Pro Pro Gly Arg Ser Tyr Ser Pro Tyr Asp Tyr Gln Pro
785                 790                 795                 800 
Cys Leu Ala Gly Pro Asn Gln Asp Phe His Ser Lys Ser Pro Ala Ser
                805                 810                 815     
Ser Ser Leu Pro Ala Phe Leu Pro Thr Thr His Ser Pro Pro Gly Pro
            820                 825                 830         
Gln Gln Pro Pro Ala Ser Leu Pro Gly Leu Thr Ala Gln Pro Leu Leu
        835                 840                 845             
Ser Pro Lys Glu Ala Thr Ser Asp Pro Ser Arg Thr Pro Glu Glu Glu
    850                 855                 860                 
Pro Leu Asn Leu Glu Gly Leu Val Ala His Arg Val Ala Gly Val Gln
865                 870                 875                 880 
Ala Arg Glu Lys Gln Pro Ala Glu Pro Pro Ala Pro Leu Arg Arg Arg
                885                 890                 895     
Ala Ala Ser Asp Gly Gln Tyr Glu Asn Gln Ser Pro Glu Ala Thr Ser
            900                 905                 910         
Pro Arg Ser Pro Gly Val Arg Ser Pro Val Gln Cys Val Ser Pro Glu
        915                 920                 925             
Leu Ala Leu Thr Ile Ala Leu Asn Pro Gly Gly Arg Pro Lys Glu Pro
    930                 935                 940                 
His Leu His Ser Tyr Lys Glu Ala Phe Glu Glu Met Glu Gly Thr Ser
945                 950                 955                 960 
Pro Ser Ser Pro Pro Pro Ser Gly Val Arg Ser Pro Pro Gly Leu Ala
                965                 970                 975     
Lys Thr Pro Leu Ser Ala Leu Gly Leu Lys Pro His Asn Pro Ala Asp
            980                 985                 990         
Ile Leu Leu His Pro Thr Gly Val Thr Arg Arg Arg Ile Gln Pro Glu
        995                 1000                1005            
Glu Asp Glu Gly Lys Val Val Val Arg Leu Ser Glu Glu Pro Arg Ser
    1010                1015                1020                
Tyr Val Glu Ser Val Ala Arg Thr Ala Val Ala Gly Pro Arg Ala Gln
1025                1030                1035                1040
Asp Ser Glu Pro Lys Ser Phe Ser Ala Pro Ala Thr Gln Ala Tyr Gly
                1045                1050                1055    
His Glu Ile Pro Leu Arg Asn Gly Thr Leu Gly Gly Ser Phe Val Ser
            1060                1065                1070        
Pro Ser Pro Leu Ser Thr Ser Ser Pro Ile Leu Ser Ala Asp Ser Thr
        1075                1080                1085            
Ser Val Gly Ser Phe Pro Ser Gly Glu Ser Ser Asp Gln Gly Pro Arg
    1090                1095                1100                
Thr Pro Thr Gln Pro Leu Leu Glu Ser Gly Phe Arg Ser Gly Ser Leu
1105                1110                1115                1120
Gly Gln Pro Ser Pro Ser Ala Gln Arg Asn Tyr Gln Ser Ser Ser Pro
                1125                1130                1135    
Leu Pro Thr Val Gly Ser Ser Tyr Ser Ser Pro Asp Tyr Ser Leu Gln
            1140                1145                1150        
His Phe Ser Ser Ser Pro Glu Ser Gln Ala Arg Ala Gln Phe Ser Val
        1155                1160                1165            
Ala Gly Val His Thr Val Pro Gly Ser Pro Gln Ala Arg His Arg Thr
    1170                1175                1180                
Val Gly Thr Asn Thr Pro Pro Ser Pro Gly Phe Gly Arg Arg Ala Ile
1185                1190                1195                1200
Asn Pro Ser Met Ala Ala Pro Ser Ser Pro Ser Leu Ser His His Gln
                1205                1210                1215    
Met Met Gly Pro Pro Gly Thr Gly Phe His Gly Ser Thr Val Ser Ser
            1220                1225                1230        
Pro Gln Ser Ser Ala Ala Thr Thr Pro Gly Ser Pro Ser Leu Cys Arg
        1235                1240                1245            
His Pro Ala Gly Val Tyr Gln Val Ser Gly Leu His Asn Lys Val Ala
    1250                1255                1260                
Thr Thr Pro Gly Ser Pro Ser Leu Gly Arg His Pro Gly Ala His Gln
1265                1270                1275                1280
Gly Asn Leu Ala Ser Gly Leu His Ser Asn Ala Ile Ala Ser Pro Gly
                1285                1290                1295    
Ser Pro Ser Leu Gly Arg His Leu Gly Gly Ser Gly Ser Val Val Pro
            1300                1305                1310        
Gly Ser Pro Cys Leu Asp Arg His Val Ala Tyr Gly Gly Tyr Ser Thr
        1315                1320                1325            
Pro Glu Asp Arg Arg Pro Thr Leu Ser Arg Gln Ser Ser Ala Ser Gly
    1330                1335                1340                
Tyr Gln Ala Pro Ser Thr Pro Ser Phe Pro Val Ser Pro Ala Tyr Tyr
1345                1350                1355                1360
Pro Gly Leu Ser Ser Pro Ala Thr Ser Pro Ser Pro Asp Ser Ala Ala
                1365                1370                1375    
Phe Arg Gln Gly Ser Pro Thr Pro Ala Leu Pro Glu Lys Arg Arg Met
            1380                1385                1390        
Ser Val Gly Asp Arg Ala Gly Ser Leu Pro Asn Tyr Ala Thr Ile Asn
        1395                1400                1405            
Gly Lys Val Ala Ser Pro Val Pro Ser Gly Met Ser Ser Pro Ser Gly
    1410                1415                1420                
Gly Ser Thr Val Ser Phe Ser His Thr Leu Pro Asp Phe Ser Lys Tyr
1425                1430                1435                1440
Ser Met Pro Asp Asn Ser Pro Glu Thr Arg Ala Lys Val Lys Phe Val
                1445                1450                1455    
Gln Asp Thr Ser Lys Tyr Trp Tyr Lys Pro Glu Ile Ser Arg Glu Gln
            1460                1465                1470        
Ala Ile Ala Leu Leu Lys Asp Gln Glu Pro Gly Ala Phe Ile Ile Arg
        1475                1480                1485            
Asp Ser His Ser Phe Arg Gly Ala Tyr Gly Leu Ala Met Lys Val Ser
    1490                1495                1500                
Ser Pro Pro Pro Thr Ile Met Gln Gln Asn Lys Lys Gly Asp Met Thr
1505                1510                1515                1520
His Glu Leu Val Arg His Phe Leu Ile Glu Thr Gly Pro Arg Gly Val
                1525                1530                1535    
Lys Leu Lys Gly Cys Pro Asn Glu Pro Asn Phe Gly Ser Leu Ser Ala
            1540                1545                1550        
Leu Val Tyr Gln His Ser Ile Ile Pro Leu Ala Leu Pro Cys Lys Leu
        1555                1560                1565            
Val Ile Pro Asn Arg Asp Pro Thr Asp Glu Ser Lys Asp Ser Ser Gly
    1570                1575                1580                
Pro Ala Asn Ser Thr Ala Asp Leu Leu Lys Gln Gly Ala Ala Cys Asn
1585                1590                1595                1600
Val Leu Phe Ile Asn Ser Val Asp Met Glu Ser Leu Thr Gly Pro Gln
                1605                1610                1615    
Ala Ile Ser Lys Ala Thr Ser Glu Thr Leu Ala Ala Asp Pro Thr Pro
            1620                1625                1630        
Ala Ala Thr Ile Val His Phe Lys Val Ser Ala Gln Gly Ile Thr Leu
        1635                1640                1645            
Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Leu Asn
    1650                1655                1660                
Thr Val Thr Phe Cys Asp Leu Asp Pro Gln Glu Arg Lys Trp Met Lys
1665                1670                1675                1680
Thr Glu Gly Gly Ala Pro Ala Lys Leu Phe Gly Phe Val Ala Arg Lys
                1685                1690                1695    
Gln Gly Ser Thr Thr Asp Asn Ala Cys His Leu Phe Ala Glu Leu Asp
            1700                1705                1710        
Pro Asn Gln Pro Ala Ser Ala Ile Val Asn Phe Val Ser Lys Val Met
        1715                1720                1725            
Leu Asn Ala Gly Gln Lys Arg
    1730                1735


<210> 8241
<211> 811
<212> PRT
<213> Homo sapiens

<400> 8241
Met Pro Leu Ser Ser Pro Asn Ala Ala Ala Thr Ala Ser Asp Met Asp
 1               5                  10                  15      
Lys Asn Ser Gly Ser Asn Ser Ser Ser Ala Ser Ser Gly Ser Ser Lys
            20                  25                  30          
Gly Gln Gln Pro Pro Arg Ser Ala Ser Ala Gly Pro Ala Gly Glu Ser
        35                  40                  45              
Lys Pro Lys Ser Asp Gly Lys Asn Ser Ser Gly Ser Lys Arg Tyr Asn
    50                  55                  60                  
Arg Lys Arg Glu Leu Ser Tyr Pro Lys Asn Glu Ser Phe Asn Asn Gln
65                  70                  75                  80  
Ser Arg Arg Ser Ser Ser Gln Lys Ser Lys Thr Phe Asn Lys Met Pro
                85                  90                  95      
Pro Gln Arg Gly Gly Gly Ser Ser Lys Leu Phe Ser Ser Ser Phe Asn
            100                 105                 110         
Gly Gly Arg Arg Asp Glu Val Ala Glu Ala Gln Arg Ala Glu Phe Ser
        115                 120                 125             
Pro Ala Gln Phe Ser Gly Pro Lys Lys Ile Asn Leu Asn His Leu Leu
    130                 135                 140                 
Asn Phe Thr Phe Glu Pro Arg Gly Gln Thr Gly His Phe Glu Gly Ser
145                 150                 155                 160 
Gly His Gly Ser Trp Gly Lys Arg Asn Lys Trp Gly His Lys Pro Phe
                165                 170                 175     
Asn Lys Glu Leu Phe Leu Gln Ala Asn Cys Gln Phe Val Val Ser Glu
            180                 185                 190         
Asp Gln Asp Tyr Thr Ala His Phe Ala Asp Pro Asp Thr Leu Val Asn
        195                 200                 205             
Trp Asp Phe Val Glu Gln Val Arg Ile Cys Ser His Glu Val Pro Ser
    210                 215                 220                 
Cys Pro Ile Cys Leu Tyr Pro Pro Thr Ala Ala Lys Ile Thr Arg Cys
225                 230                 235                 240 
Gly His Ile Phe Cys Trp Ala Cys Ile Leu His Tyr Leu Ser Leu Ser
                245                 250                 255     
Glu Lys Thr Trp Ser Lys Cys Pro Ile Cys Tyr Ser Ser Val His Lys
            260                 265                 270         
Lys Asp Leu Lys Ser Val Val Ala Thr Glu Ser His Gln Tyr Val Val
        275                 280                 285             
Gly Asp Thr Ile Thr Met Gln Leu Met Lys Arg Glu Lys Gly Val Leu
    290                 295                 300                 
Val Ala Leu Pro Lys Ser Lys Trp Met Asn Val Asp His Pro Ile His
305                 310                 315                 320 
Leu Gly Asp Glu Gln His Ser Gln Tyr Ser Lys Phe Leu Leu Ala Ser
                325                 330                 335     
Lys Glu Gln Val Leu His Arg Val Val Leu Glu Glu Lys Val Ala Leu
            340                 345                 350         
Glu Gln Gln Leu Ala Glu Glu Lys His Thr Pro Glu Ser Cys Phe Ile
        355                 360                 365             
Glu Ala Ala Ile Gln Glu Leu Lys Thr Arg Glu Glu Ala Leu Ser Gly
    370                 375                 380                 
Leu Ala Gly Ser Arg Arg Glu Val Thr Gly Val Val Ala Ala Leu Glu
385                 390                 395                 400 
Gln Leu Val Leu Met Ala Pro Leu Ala Lys Glu Ser Val Phe Gln Pro
                405                 410                 415     
Arg Lys Gly Val Leu Glu Tyr Leu Ser Ala Phe Asp Glu Glu Thr Thr
            420                 425                 430         
Glu Val Cys Ser Leu Asp Thr Pro Ser Arg Pro Leu Ala Leu Pro Leu
        435                 440                 445             
Val Glu Glu Glu Glu Ala Val Ser Glu Pro Glu Pro Glu Gly Leu Pro
    450                 455                 460                 
Glu Ala Cys Asp Asp Leu Glu Leu Ala Asp Asp Asn Leu Lys Glu Gly
465                 470                 475                 480 
Thr Ile Cys Thr Glu Ser Ser Gln Gln Glu Pro Ile Thr Lys Ser Gly
                485                 490                 495     
Phe Thr Arg Leu Ser Ser Ser Pro Cys Tyr Tyr Phe Tyr Gln Ala Glu
            500                 505                 510         
Asp Gly Gln His Met Phe Leu His Pro Val Asn Val Arg Cys Leu Val
        515                 520                 525             
Arg Glu Tyr Gly Ser Leu Glu Arg Ser Pro Glu Lys Ile Ser Ala Thr
    530                 535                 540                 
Val Val Glu Ile Ala Gly Tyr Ser Met Ser Glu Asp Val Arg Gln Arg
545                 550                 555                 560 
His Arg Tyr Leu Ser His Leu Pro Leu Thr Cys Glu Phe Ser Ile Cys
                565                 570                 575     
Glu Leu Ala Leu Gln Pro Pro Val Val Ser Lys Glu Thr Leu Glu Met
            580                 585                 590         
Phe Ser Asp Asp Ile Glu Lys Arg Lys Arg Gln Arg Gln Lys Lys Ala
        595                 600                 605             
Arg Glu Glu Arg Arg Arg Glu Arg Arg Ile Glu Ile Glu Glu Asn Lys
    610                 615                 620                 
Lys Gln Gly Lys Tyr Pro Glu Val His Ile Pro Leu Glu Asn Leu Gln
625                 630                 635                 640 
Gln Phe Pro Ala Phe Asn Ser Tyr Thr Cys Ser Ser Asp Ser Ala Leu
                645                 650                 655     
Gly Pro Thr Ser Thr Glu Gly His Gly Ala Leu Ser Ile Ser Pro Leu
            660                 665                 670         
Ser Arg Ser Pro Gly Ser His Ala Asp Phe Leu Leu Thr Pro Leu Ser
        675                 680                 685             
Pro Thr Ala Ser Gln Gly Ser Pro Ser Phe Cys Val Gly Ser Leu Glu
    690                 695                 700                 
Glu Asp Ser Pro Phe Pro Ser Phe Ala Gln Met Leu Arg Val Gly Lys
705                 710                 715                 720 
Ala Lys Ala Asp Val Trp Pro Lys Thr Ala Pro Lys Lys Asp Glu Asn
                725                 730                 735     
Ser Leu Val Pro Pro Ala Pro Val Asp Ser Asp Gly Glu Ser Asp Asn
            740                 745                 750         
Ser Asp Arg Val Pro Val Pro Ser Phe Gln Asn Ser Phe Ser Gln Ala
        755                 760                 765             
Ile Glu Ala Ala Phe Met Lys Leu Asp Thr Pro Ala Thr Ser Asp Pro
    770                 775                 780                 
Leu Ser Glu Glu Lys Gly Gly Lys Lys Arg Lys Lys Gln Lys Gln Lys
785                 790                 795                 800 
Leu Leu Phe Ser Thr Ser Val Val His Thr Lys
                805                 810     


<210> 8242
<211> 811
<212> PRT
<213> Homo sapiens

<400> 8242
Met Pro Leu Ser Ser Pro Asn Ala Ala Ala Thr Ala Ser Asp Met Asp
 1               5                  10                  15      
Lys Asn Ser Gly Ser Asn Ser Ser Ser Ala Ser Ser Gly Ser Ser Lys
            20                  25                  30          
Gly Gln Gln Pro Pro Arg Ser Ala Ser Ala Gly Pro Ala Gly Glu Ser
        35                  40                  45              
Lys Pro Lys Ser Asp Gly Lys Asn Ser Ser Gly Ser Lys Arg Tyr Asn
    50                  55                  60                  
Arg Lys Arg Glu Leu Ser Tyr Pro Lys Asn Glu Ser Phe Asn Asn Gln
65                  70                  75                  80  
Ser Arg Arg Ser Ser Ser Gln Lys Ser Lys Thr Phe Asn Lys Met Pro
                85                  90                  95      
Pro Gln Arg Gly Gly Gly Ser Ser Lys Leu Phe Ser Ser Ser Phe Asn
            100                 105                 110         
Gly Gly Arg Arg Asp Glu Val Ala Glu Ala Gln Arg Ala Glu Phe Ser
        115                 120                 125             
Pro Ala Gln Phe Ser Gly Pro Lys Lys Ile Asn Leu Asn His Leu Leu
    130                 135                 140                 
Asn Phe Thr Phe Glu Pro Arg Gly Gln Thr Gly His Phe Glu Gly Ser
145                 150                 155                 160 
Gly His Gly Ser Trp Gly Lys Arg Asn Lys Trp Gly His Lys Pro Phe
                165                 170                 175     
Asn Lys Glu Leu Phe Leu Gln Ala Asn Cys Gln Phe Val Val Ser Glu
            180                 185                 190         
Asp Gln Asp Tyr Thr Ala His Phe Ala Asp Pro Asp Thr Leu Val Asn
        195                 200                 205             
Trp Asp Phe Val Glu Gln Val Arg Ile Cys Ser His Glu Val Pro Ser
    210                 215                 220                 
Cys Pro Ile Cys Leu Tyr Pro Pro Thr Ala Ala Lys Ile Thr Arg Cys
225                 230                 235                 240 
Gly His Ile Phe Cys Trp Ala Cys Ile Leu His Tyr Leu Ser Leu Ser
                245                 250                 255     
Glu Lys Thr Trp Ser Lys Cys Pro Ile Cys Tyr Ser Ser Val His Lys
            260                 265                 270         
Lys Asp Leu Lys Ser Val Val Ala Thr Glu Ser His Gln Tyr Val Val
        275                 280                 285             
Gly Asp Thr Ile Thr Met Gln Leu Met Lys Arg Glu Lys Gly Val Leu
    290                 295                 300                 
Val Ala Leu Pro Lys Ser Lys Trp Met Asn Val Asp His Pro Ile His
305                 310                 315                 320 
Leu Gly Asp Glu Gln His Ser Gln Tyr Ser Lys Leu Leu Leu Ala Ser
                325                 330                 335     
Lys Glu Gln Val Leu His Arg Val Val Leu Glu Glu Lys Val Ala Leu
            340                 345                 350         
Glu Gln Gln Leu Ala Glu Glu Lys His Thr Pro Glu Ser Cys Phe Ile
        355                 360                 365             
Glu Ala Ala Ile Gln Glu Leu Lys Thr Arg Glu Glu Ala Leu Ser Gly
    370                 375                 380                 
Leu Ala Gly Ser Arg Arg Glu Val Thr Gly Val Val Ala Ala Leu Glu
385                 390                 395                 400 
Gln Leu Val Leu Met Ala Pro Leu Ala Lys Glu Ser Val Phe Gln Pro
                405                 410                 415     
Arg Lys Gly Val Leu Glu Tyr Leu Ser Ala Phe Asp Glu Glu Thr Thr
            420                 425                 430         
Glu Val Cys Ser Leu Asp Thr Pro Ser Arg Pro Leu Ala Leu Pro Leu
        435                 440                 445             
Val Glu Glu Glu Glu Ala Val Ser Glu Pro Glu Pro Glu Gly Leu Pro
    450                 455                 460                 
Glu Ala Cys Asp Asp Leu Glu Leu Ala Asp Asp Asn Leu Lys Glu Gly
465                 470                 475                 480 
Thr Ile Cys Thr Glu Ser Ser Gln Gln Glu Pro Ile Thr Lys Ser Gly
                485                 490                 495     
Phe Thr Arg Leu Ser Ser Ser Pro Cys Tyr Tyr Phe Tyr Gln Ala Glu
            500                 505                 510         
Asp Gly Gln His Met Phe Leu His Pro Val Asn Val Arg Cys Leu Val
        515                 520                 525             
Arg Glu Tyr Gly Ser Leu Glu Arg Ser Pro Glu Lys Ile Ser Ala Thr
    530                 535                 540                 
Val Val Glu Ile Ala Gly Tyr Ser Met Ser Glu Asp Val Arg Gln Arg
545                 550                 555                 560 
His Arg Tyr Leu Ser His Leu Pro Leu Thr Cys Glu Phe Ser Ile Cys
                565                 570                 575     
Glu Leu Ala Leu Gln Pro Pro Val Val Ser Lys Glu Thr Leu Glu Met
            580                 585                 590         
Phe Ser Asp Asp Ile Glu Lys Arg Lys Arg Gln Arg Gln Lys Lys Ala
        595                 600                 605             
Arg Glu Glu Arg Arg Arg Glu Arg Arg Ile Glu Ile Glu Glu Asn Lys
    610                 615                 620                 
Lys Gln Gly Lys Tyr Pro Glu Val His Ile Pro Leu Glu Asn Leu Gln
625                 630                 635                 640 
Gln Phe Pro Ala Phe Asn Ser Tyr Thr Cys Ser Ser Asp Ser Ala Leu
                645                 650                 655     
Gly Pro Thr Ser Thr Glu Gly His Gly Ala Leu Ser Ile Ser Pro Leu
            660                 665                 670         
Ser Arg Ser Pro Gly Ser His Ala Asp Phe Leu Leu Thr Pro Leu Ser
        675                 680                 685             
Pro Thr Ala Ser Gln Gly Ser Pro Ser Phe Cys Val Gly Ser Leu Glu
    690                 695                 700                 
Glu Asp Ser Pro Phe Pro Ser Phe Ala Gln Met Leu Arg Val Gly Lys
705                 710                 715                 720 
Ala Lys Ala Asp Val Trp Pro Lys Thr Ala Pro Lys Lys Asp Glu Asn
                725                 730                 735     
Ser Leu Val Pro Pro Ala Pro Val Asp Ser Asp Gly Glu Ser Asp Asn
            740                 745                 750         
Ser Asp Arg Val Pro Val Pro Ser Phe Gln Asn Ser Phe Ser Gln Ala
        755                 760                 765             
Ile Glu Ala Ala Phe Met Lys Leu Asp Thr Pro Ala Thr Ser Asp Pro
    770                 775                 780                 
Leu Ser Glu Glu Lys Gly Gly Lys Lys Arg Lys Lys Gln Lys Gln Lys
785                 790                 795                 800 
Leu Leu Phe Ser Thr Ser Val Val His Thr Lys
                805                 810     


<210> 8243
<211> 290
<212> PRT
<213> Homo sapiens

<400> 8243
Met Glu Leu Pro Ala Val Gly Glu His Val Phe Ala Val Glu Ser Ile
 1               5                  10                  15      
Glu Lys Lys Arg Ile Arg Lys Gly Arg Val Glu Tyr Leu Val Lys Trp
            20                  25                  30          
Arg Gly Trp Ser Pro Lys Tyr Asn Thr Trp Glu Pro Glu Glu Asn Ile
        35                  40                  45              
Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Arg Glu Arg Gln Glu
    50                  55                  60                  
Gln Leu Met Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Pro Leu Val
65                  70                  75                  80  
Val Gln Val Pro Thr Phe Ala Arg Arg Ser Asn Val Leu Thr Gly Leu
                85                  90                  95      
Gln Asp Ser Ser Thr Asp Asn Arg Ala Lys Leu Asp Leu Gly Ala Gln
            100                 105                 110         
Gly Lys Gly Gln Gly His Gln Tyr Glu Leu Asn Ser Lys Lys His His
        115                 120                 125             
His His Ala Val Gly Leu Asn Leu Ser His Val Arg Lys Arg Cys Leu
    130                 135                 140                 
Ser Glu Thr His Gly Glu Arg Glu Pro Cys Lys Lys Arg Leu Thr Ala
145                 150                 155                 160 
Arg Ser Ile Ser Thr Pro Thr Cys Leu Gly Gly Ser Pro Ala Ala Glu
                165                 170                 175     
Arg Pro Ala Asp Leu Pro Pro Ala Ala Ala Leu Arg Gln Pro Glu Val
            180                 185                 190         
Ile Leu Leu Asp Ser Asp Leu Asp Glu Pro Ile Asp Leu Arg Ser Val
        195                 200                 205             
Lys Ser Arg Ser Glu Ala Gly Glu Pro Pro Ser Ser Leu Gln Val Lys
    210                 215                 220                 
Pro Glu Thr Pro Ala Ser Ala Ala Val Ala Val Ala Ala Ala Ala Ala
225                 230                 235                 240 
Pro Thr Thr Thr Ala Glu Lys Pro Pro Ala Glu Ala Gln Asp Glu Pro
                245                 250                 255     
Ala Glu Ser Leu Ser Glu Phe Lys Pro Phe Phe Gly Asn Ile Ile Ile
            260                 265                 270         
Thr Asp Val Thr Ala Asn Cys Leu Thr Val Thr Phe Lys Glu Tyr Val
        275                 280                 285             
Thr Val
    290 


<210> 8244
<211> 1063
<212> PRT
<213> Homo sapiens

<400> 8244
Leu Asp Ser Arg Arg Leu Thr Phe Gln Ser Cys Ala Pro Asp Pro Ala
 1               5                  10                  15      
Leu Gly Ile Cys Pro Arg Leu Gln Gly Cys Gly Ala Trp Lys Glu Ala
            20                  25                  30          
Tyr Arg Gly Gly Ser Lys Thr Ile Gln Gly Ser Arg Gly Ala Pro Leu
        35                  40                  45              
Val Ile Pro Leu Ser Ala Met Ser Trp Met Phe Lys Arg Asp Pro Val
    50                  55                  60                  
Trp Lys Tyr Leu Gln Thr Val Gln Tyr Gly Val His Gly Asn Phe Pro
65                  70                  75                  80  
Arg Leu Ser Tyr Pro Thr Phe Phe Pro Arg Phe Glu Phe Gln Asp Val
                85                  90                  95      
Ile Pro Pro Asp Asp Phe Leu Thr Ser Asp Glu Glu Val Asp Ser Val
            100                 105                 110         
Leu Phe Gly Ser Leu Arg Gly His Val Val Gly Leu Arg Tyr Tyr Thr
        115                 120                 125             
Gly Val Val Asn Asn Asn Glu Met Val Ala Leu Gln Arg Asp Pro Asn
    130                 135                 140                 
Asn Pro Tyr Asp Lys Asn Ala Ile Lys Val Asn Asn Val Asn Gly Asn
145                 150                 155                 160 
Gln Val Gly His Leu Lys Lys Glu Leu Ala Gly Ala Leu Ala Tyr Ile
                165                 170                 175     
Met Asp Asn Lys Leu Ala Gln Ile Glu Gly Val Val Pro Phe Gly Ala
            180                 185                 190         
Asn Asn Ala Phe Thr Met Pro Leu His Met Thr Phe Trp Gly Lys Glu
        195                 200                 205             
Glu Asn Arg Lys Ala Val Ser Asp Gln Leu Lys Lys His Gly Phe Lys
    210                 215                 220                 
Leu Gly Pro Ala Pro Lys Thr Leu Gly Phe Asn Leu Glu Ser Gly Trp
225                 230                 235                 240 
Gly Ser Gly Arg Ala Gly Pro Ser Tyr Ser Met Pro Val His Ala Ala
                245                 250                 255     
Val Gln Met Thr Thr Glu Gln Leu Lys Thr Glu Phe Asp Lys Leu Phe
            260                 265                 270         
Glu Asp Leu Lys Glu Asp Asp Lys Thr His Glu Met Glu Pro Ala Glu
        275                 280                 285             
Ala Ile Glu Thr Pro Leu Leu Pro His Gln Lys Gln Ala Leu Ala Trp
    290                 295                 300                 
Met Val Ser Arg Glu Asn Ser Lys Glu Leu Pro Pro Phe Trp Glu Gln
305                 310                 315                 320 
Arg Asn Asp Leu Tyr Tyr Asn Thr Ile Thr Asn Phe Ser Glu Lys Asp
                325                 330                 335     
Arg Pro Glu Asn Val His Gly Gly Ile Leu Ala Asp Asp Met Gly Leu
            340                 345                 350         
Gly Lys Thr Leu Thr Ala Ile Ala Val Ile Leu Thr Asn Phe His Asp
        355                 360                 365             
Gly Arg Pro Leu Pro Ile Glu Arg Val Lys Lys Asn Leu Leu Lys Lys
    370                 375                 380                 
Glu Tyr Asn Val Asn Asp Asp Ser Met Lys Leu Gly Gly Asn Asn Thr
385                 390                 395                 400 
Ser Glu Lys Ala Asp Gly Leu Ser Lys Asp Ala Ser Arg Cys Ser Glu
                405                 410                 415     
Gln Pro Ser Ile Ser Asp Ile Lys Glu Lys Ser Lys Phe Arg Met Ser
            420                 425                 430         
Glu Leu Ser Ser Ser Arg Pro Lys Arg Arg Lys Thr Ala Val Gln Tyr
        435                 440                 445             
Ile Glu Ser Ser Asp Ser Glu Glu Ile Glu Thr Ser Glu Leu Pro Gln
    450                 455                 460                 
Lys Met Lys Gly Lys Leu Lys Asn Val Gln Ser Glu Thr Lys Gly Arg
465                 470                 475                 480 
Ala Lys Ala Gly Ser Ser Lys Val Ile Glu Asp Val Ala Phe Ala Cys
                485                 490                 495     
Ala Leu Thr Ser Ser Val Pro Thr Thr Lys Lys Lys Met Leu Lys Lys
            500                 505                 510         
Gly Ala Cys Ala Val Glu Gly Ser Lys Lys Thr Asp Val Glu Glu Arg
        515                 520                 525             
Pro Arg Thr Thr Leu Ile Ile Cys Pro Leu Ser Val Leu Ser Asn Trp
    530                 535                 540                 
Ile Asp Gln Phe Gly Gln His Ile Lys Ser Asp Val His Leu Asn Phe
545                 550                 555                 560 
Tyr Val Tyr Tyr Gly Pro Asp Arg Ile Arg Glu Pro Ala Leu Leu Ser
                565                 570                 575     
Lys Gln Asp Ile Val Leu Thr Thr Tyr Asn Ile Leu Thr His Asp Tyr
            580                 585                 590         
Gly Thr Lys Gly Asp Ser Pro Leu His Ser Ile Arg Trp Leu Arg Val
        595                 600                 605             
Ile Leu Asp Glu Gly His Ala Ile Arg Asn Pro Asn Ala Gln Gln Thr
    610                 615                 620                 
Lys Ala Val Leu Asp Leu Glu Ser Glu Arg Arg Trp Val Leu Thr Gly
625                 630                 635                 640 
Thr Pro Ile Gln Asn Ser Leu Lys Asp Leu Trp Ser Leu Leu Ser Phe
                645                 650                 655     
Leu Lys Leu Lys Pro Phe Ile Asp Arg Glu Trp Trp His Arg Thr Ile
            660                 665                 670         
Gln Arg Pro Val Thr Met Gly Asp Glu Gly Gly Leu Arg Arg Leu Gln
        675                 680                 685             
Ser Leu Ile Lys Asn Ile Thr Leu Arg Arg Thr Lys Thr Ser Lys Ile
    690                 695                 700                 
Lys Gly Lys Pro Val Leu Glu Leu Pro Glu Arg Lys Val Phe Ile Gln
705                 710                 715                 720 
His Ile Thr Leu Ser Asp Glu Glu Arg Lys Ile Tyr Gln Ser Val Lys
                725                 730                 735     
Asn Glu Gly Arg Ala Thr Ile Gly Arg Tyr Phe Asn Glu Gly Thr Val
            740                 745                 750         
Leu Ala His Tyr Ala Asp Val Leu Gly Leu Leu Leu Arg Leu Arg Gln
        755                 760                 765             
Ile Cys Cys His Thr Tyr Leu Leu Thr Asn Ala Val Ser Ser Asn Gly
    770                 775                 780                 
Pro Ser Gly Asn Asp Thr Pro Glu Glu Leu Arg Lys Lys Leu Ile Arg
785                 790                 795                 800 
Lys Met Lys Leu Ile Leu Ser Ser Gly Ser Asp Glu Glu Cys Ala Ile
                805                 810                 815     
Cys Leu Asp Ser Leu Thr Val Pro Val Ile Thr His Cys Ala His Val
            820                 825                 830         
Phe Cys Lys Pro Cys Ile Cys Gln Val Ile Gln Asn Glu Gln Pro His
        835                 840                 845             
Ala Lys Cys Pro Leu Cys Arg Asn Asp Ile His Glu Asp Asn Leu Leu
    850                 855                 860                 
Glu Cys Pro Pro Glu Glu Leu Ala Arg Asp Ser Glu Lys Lys Ser Asp
865                 870                 875                 880 
Met Glu Trp Thr Ser Ser Ser Lys Ile Asn Ala Leu Met His Ala Leu
                885                 890                 895     
Thr Asp Leu Arg Lys Lys Asn Pro Asn Ile Lys Ser Leu Val Val Ser
            900                 905                 910         
Gln Phe Thr Thr Phe Leu Ser Leu Ile Glu Ile Pro Leu Lys Ala Ser
        915                 920                 925             
Gly Phe Val Phe Thr Arg Leu Asp Gly Ser Met Ala Gln Lys Lys Arg
    930                 935                 940                 
Val Glu Ser Ile Gln Cys Phe Gln Asn Thr Glu Ala Gly Ser Pro Thr
945                 950                 955                 960 
Ile Met Leu Leu Ser Leu Lys Ala Gly Gly Val Gly Leu Asn Leu Ser
                965                 970                 975     
Ala Ala Ser Arg Val Phe Leu Met Asp Pro Ala Trp Asn Pro Ala Ala
            980                 985                 990         
Glu Asp Gln Cys Phe Asp Arg Cys His Arg Leu Gly Gln Lys Gln Glu
        995                 1000                1005            
Val Ile Ile Thr Lys Phe Ile Val Lys Asp Ser Val Glu Glu Asn Met
    1010                1015                1020                
Leu Lys Ile Gln Asn Lys Lys Arg Glu Leu Ala Ala Gly Ala Phe Gly
1025                1030                1035                1040
Thr Lys Lys Pro Asn Ala Asp Glu Met Lys Gln Ala Lys Ile Asn Glu
                1045                1050                1055    
Ile Arg Thr Leu Ile Asp Leu
            1060            


<210> 8245
<211> 626
<212> PRT
<213> Homo sapiens

<400> 8245
Met Gln Arg Ala Asp Ser Glu Gln Pro Ser Lys Arg Pro Arg Cys Asp
 1               5                  10                  15      
Asp Ser Pro Arg Thr Pro Ser Asn Thr Pro Ser Ala Glu Ala Asp Trp
            20                  25                  30          
Ser Pro Gly Leu Glu Leu His Pro Asp Tyr Lys Thr Trp Gly Pro Glu
        35                  40                  45              
Gln Val Cys Ser Phe Leu Arg Arg Gly Gly Phe Glu Glu Pro Val Leu
    50                  55                  60                  
Leu Lys Asn Ile Arg Glu Asn Glu Ile Thr Gly Ala Leu Leu Pro Cys
65                  70                  75                  80  
Leu Asp Glu Ser Arg Phe Glu Asn Leu Gly Val Ser Ser Leu Gly Glu
                85                  90                  95      
Arg Lys Lys Leu Leu Ser Tyr Ile Gln Arg Leu Val Gln Ile His Val
            100                 105                 110         
Asp Thr Met Lys Val Ile Asn Asp Pro Ile His Gly His Ile Glu Leu
        115                 120                 125             
His Pro Leu Leu Val Arg Ile Ile Asp Thr Pro Gln Phe Gln Arg Leu
    130                 135                 140                 
Arg Tyr Ile Lys Gln Leu Gly Gly Gly Tyr Tyr Val Phe Pro Gly Ala
145                 150                 155                 160 
Ser His Asn Arg Phe Glu His Ser Leu Gly Val Gly Tyr Leu Ala Gly
                165                 170                 175     
Cys Leu Val His Ala Leu Gly Glu Lys Gln Pro Glu Leu Gln Ile Ser
            180                 185                 190         
Glu Arg Asp Val Leu Cys Val Gln Ile Ala Gly Leu Cys His Asp Leu
        195                 200                 205             
Gly His Gly Pro Phe Ser His Met Phe Asp Gly Arg Phe Ile Pro Leu
    210                 215                 220                 
Ala Arg Pro Glu Val Lys Trp Thr His Glu Gln Gly Ser Val Met Met
225                 230                 235                 240 
Phe Glu His Leu Ile Asn Ser Asn Gly Ile Lys Pro Val Met Glu Gln
                245                 250                 255     
Tyr Gly Leu Ile Pro Glu Glu Asp Ile Cys Phe Ile Lys Glu Gln Ile
            260                 265                 270         
Val Gly Pro Leu Glu Ser Pro Val Glu Asp Ser Leu Trp Pro Tyr Lys
        275                 280                 285             
Gly Arg Pro Glu Asn Lys Ser Phe Leu Tyr Glu Ile Val Ser Asn Lys
    290                 295                 300                 
Arg Asn Gly Ile Asp Val Asp Lys Trp Asp Tyr Phe Ala Arg Asp Cys
305                 310                 315                 320 
His His Leu Gly Ile Gln Asn Asn Phe Asp Tyr Lys Arg Phe Ile Lys
                325                 330                 335     
Phe Ala Arg Val Cys Glu Val Asp Asn Glu Leu Arg Ile Cys Ala Arg
            340                 345                 350         
Asp Lys Glu Val Gly Asn Leu Tyr Asp Met Phe His Thr Arg Asn Ser
        355                 360                 365             
Leu His Arg Arg Ala Tyr Gln His Lys Val Gly Asn Ile Ile Asp Thr
    370                 375                 380                 
Met Ile Thr Asp Ala Phe Leu Lys Ala Asp Asp Tyr Ile Glu Ile Thr
385                 390                 395                 400 
Gly Ala Gly Gly Lys Lys Tyr Arg Ile Ser Thr Ala Ile Asp Asp Met
                405                 410                 415     
Glu Ala Tyr Thr Lys Leu Thr Asp Asn Ile Phe Leu Glu Ile Leu Tyr
            420                 425                 430         
Ser Thr Asp Pro Lys Leu Lys Asp Ala Arg Glu Ile Leu Lys Gln Ile
        435                 440                 445             
Glu Tyr Arg Asn Leu Phe Lys Tyr Val Gly Glu Thr Gln Pro Thr Gly
    450                 455                 460                 
Gln Ile Lys Ile Lys Arg Glu Asp Tyr Glu Ser Leu Pro Lys Glu Val
465                 470                 475                 480 
Ala Ser Ala Lys Pro Lys Val Leu Leu Asp Val Lys Leu Lys Ala Glu
                485                 490                 495     
Asp Phe Ile Val Asp Val Ile Asn Met Asp Tyr Gly Met Gln Glu Lys
            500                 505                 510         
Asn Pro Ile Asp His Val Ser Phe Tyr Cys Lys Thr Ala Pro Asn Arg
        515                 520                 525             
Ala Ile Arg Ile Thr Lys Asn Gln Val Ser Gln Leu Leu Pro Glu Lys
    530                 535                 540                 
Phe Ala Glu Gln Leu Ile Arg Val Tyr Cys Lys Lys Val Asp Arg Lys
545                 550                 555                 560 
Ser Leu Tyr Ala Ala Arg Gln Tyr Phe Val Gln Trp Cys Ala Asp Arg
                565                 570                 575     
Asn Phe Thr Lys Pro Gln Asp Gly Asp Val Ile Ala Pro Leu Ile Thr
            580                 585                 590         
Pro Gln Lys Lys Glu Trp Asn Asp Ser Thr Ser Val Gln Asn Pro Thr
        595                 600                 605             
Arg Leu Arg Glu Ala Ser Lys Ser Arg Val Gln Leu Phe Lys Asp Asp
    610                 615                 620                 
Pro Met
625     


<210> 8246
<211> 285
<212> PRT
<213> Homo sapiens

<400> 8246
Met Ser Lys Lys Pro Pro Asn Arg Pro Gly Ile Thr Phe Glu Ile Gly
 1               5                  10                  15      
Ala Arg Leu Glu Ala Leu Asp Tyr Leu Gln Lys Trp Tyr Pro Ser Arg
            20                  25                  30          
Ile Glu Lys Ile Asp Tyr Glu Glu Gly Lys Met Leu Val His Phe Glu
        35                  40                  45              
Arg Trp Ser His Arg Tyr Asp Glu Trp Ile Tyr Trp Asp Ser Asn Arg
    50                  55                  60                  
Leu Arg Pro Leu Glu Arg Pro Ala Leu Arg Lys Glu Gly Leu Lys Asp
65                  70                  75                  80  
Glu Glu Asp Phe Phe Asp Phe Lys Ala Gly Glu Glu Val Leu Ala Arg
                85                  90                  95      
Trp Thr Asp Cys Arg Tyr Tyr Pro Ala Lys Ile Glu Ala Ile Asn Lys
            100                 105                 110         
Glu Gly Thr Phe Thr Val Gln Phe Tyr Asp Gly Val Ile Arg Cys Leu
        115                 120                 125             
Lys Arg Met His Ile Lys Ala Met Pro Glu Asp Ala Lys Gly Gln Asp
    130                 135                 140                 
Trp Ile Ala Leu Val Lys Ala Ala Ala Ala Ala Ala Ala Lys Asn Lys
145                 150                 155                 160 
Thr Gly Ser Lys Pro Arg Thr Ser Ala Asn Ser Asn Lys Asp Lys Asp
                165                 170                 175     
Lys Asp Glu Arg Lys Trp Phe Lys Val Pro Ser Lys Lys Glu Glu Thr
            180                 185                 190         
Ser Thr Cys Ile Ala Thr Pro Asp Val Glu Lys Lys Glu Asp Leu Pro
        195                 200                 205             
Thr Ser Ser Glu Thr Phe Gly Leu His Val Glu Asn Val Pro Lys Met
    210                 215                 220                 
Val Phe Pro Gln Pro Glu Ser Thr Leu Ser Asn Lys Arg Lys Asn Asn
225                 230                 235                 240 
Gln Gly Asn Ser Phe Gln Ala Lys Arg Ala Arg Leu Asn Lys Ile Thr
                245                 250                 255     
Gly Leu Leu Ala Ser Lys Ala Val Gly Val Asp Gly Ala Glu Lys Lys
            260                 265                 270         
Glu Asp Tyr Asn Glu Thr Ala Pro Met Leu Glu Gln Val
        275                 280                 285 


<210> 8247
<211> 150
<212> PRT
<213> Homo sapiens

<400> 8247
Met Phe Cys Val Phe Pro Leu Glu Asp Trp Ile Ala Leu Val Lys Ala
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Lys Asn Lys Thr Gly Ser Lys Pro Arg Thr
            20                  25                  30          
Ser Ala Asn Ser Asn Lys Asp Lys Asp Lys Asp Glu Arg Lys Trp Phe
        35                  40                  45              
Lys Val Pro Ser Lys Lys Glu Glu Thr Ser Thr Cys Ile Ala Thr Pro
    50                  55                  60                  
Asp Val Glu Lys Lys Glu Asp Leu Pro Thr Ser Ser Glu Thr Phe Gly
65                  70                  75                  80  
Leu His Val Glu Asn Val Pro Lys Met Val Phe Pro Gln Pro Glu Ser
                85                  90                  95      
Thr Leu Ser Asn Lys Arg Lys Asn Asn Gln Gly Ser Ser Phe Gln Ala
            100                 105                 110         
Lys Arg Ala Arg Leu Asn Lys Ile Thr Gly Leu Leu Ala Ser Lys Ala
        115                 120                 125             
Val Gly Val Asp Gly Ala Glu Lys Lys Glu Asp Tyr Asn Glu Thr Ala
    130                 135                 140                 
Pro Met Leu Glu Gln Val
145                 150 


<210> 8248
<211> 510
<212> PRT
<213> Homo sapiens

<400> 8248
Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr
 1               5                  10                  15      
Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn
            20                  25                  30          
Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp
        35                  40                  45              
Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys
    50                  55                  60                  
Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys
65                  70                  75                  80  
Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu
                85                  90                  95      
Ser Met Gly Asn Tyr Met Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys
            100                 105                 110         
Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro
        115                 120                 125             
Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile
    130                 135                 140                 
Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu
145                 150                 155                 160 
Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr
                165                 170                 175     
Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser
            180                 185                 190         
Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe
        195                 200                 205             
Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Arg
    210                 215                 220                 
Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys
225                 230                 235                 240 
Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys
                245                 250                 255     
Tyr Thr Val Asp Lys Arg Lys Ala Glu Arg Glu Val Lys Ala Leu Ala
            260                 265                 270         
Lys Leu Asp His Val Asn Ile Val His Tyr Asn Gly Cys Trp Asp Gly
        275                 280                 285             
Phe Asp Tyr Asp Pro Glu Thr Ser Asp Asp Ser Leu Glu Ser Ser Asp
    290                 295                 300                 
Tyr Asp Pro Glu Asn Ser Lys Asn Ser Ser Arg Ser Lys Thr Lys Cys
305                 310                 315                 320 
Leu Phe Ile Gln Met Glu Phe Cys Asp Lys Gly Thr Leu Glu Gln Trp
                325                 330                 335     
Ile Glu Lys Arg Arg Gly Glu Lys Leu Asp Lys Val Leu Ala Leu Glu
            340                 345                 350         
Leu Phe Glu Gln Ile Thr Lys Gly Val Asp Tyr Ile His Ser Lys Lys
        355                 360                 365             
Leu Ile His Arg Asp Leu Lys Pro Ser Asn Ile Phe Leu Val Asp Thr
    370                 375                 380                 
Lys Gln Val Lys Ile Gly Asp Phe Gly Leu Val Thr Ser Leu Lys Asn
385                 390                 395                 400 
Asp Gly Lys Arg Thr Arg Ser Lys Gly Thr Leu Arg Tyr Met Ser Pro
                405                 410                 415     
Glu Gln Ile Ser Ser Gln Asp Tyr Gly Lys Glu Val Asp Leu Tyr Ala
            420                 425                 430         
Leu Gly Leu Ile Leu Ala Glu Leu Leu His Val Cys Asp Thr Ala Phe
        435                 440                 445             
Glu Thr Ser Lys Phe Phe Thr Asp Leu Arg Asp Gly Ile Ile Ser Asp
    450                 455                 460                 
Ile Phe Asp Lys Lys Glu Lys Thr Leu Leu Gln Lys Leu Leu Ser Lys
465                 470                 475                 480 
Lys Pro Glu Asp Arg Pro Asn Thr Ser Glu Ile Leu Arg Thr Leu Thr
                485                 490                 495     
Val Trp Lys Lys Ser Pro Glu Lys Asn Glu Arg His Thr Cys
            500                 505                 510 


<210> 8249
<211> 407
<212> PRT
<213> Homo sapiens

<400> 8249
Met Ile Pro Lys Ala Arg Glu Ser Phe Leu Glu Lys Arg Pro Asp Gly
 1               5                  10                  15      
Pro His Gln Lys Glu Lys Phe Ile Lys His Ile Ala Leu Lys Thr Pro
            20                  25                  30          
Gly Asp Val Leu Arg Leu Glu Asp Ile Ser Lys Glu Pro Ser Asp Glu
        35                  40                  45              
Thr Asp Gly Ser Ser Ala Gly Leu Ala Pro Ser Asn Ser Gly Asn Ser
    50                  55                  60                  
Gly His His Ser Thr Arg Asn Ser Asp Gln Ile Gln Val Ala Gly Thr
65                  70                  75                  80  
Lys Glu Thr Lys Met Gln Lys Pro His Leu Pro Leu Ser Gln Glu Lys
                85                  90                  95      
Ser Ala Ile Lys Lys Ala Ser Asn Leu Gln Lys Asn Lys Thr Ala Ser
            100                 105                 110         
Ser Thr Thr Lys Glu Lys Glu Thr Lys Leu Pro Leu Leu Ser Arg Val
        115                 120                 125             
Pro Ser Ala Gly Ser Ser Leu Val Pro Leu Asn Ala Lys Asn Cys Ala
    130                 135                 140                 
Leu Pro Val Ser Lys Lys Asp Lys Glu Arg Ser Ser Ser Lys Glu Cys
145                 150                 155                 160 
Ser Gly His Ser Thr Glu Ser Thr Lys His Lys Glu His Lys Ala Lys
                165                 170                 175     
Thr Asn Lys Ala Asp Ser Asn Val Ser Ser Gly Lys Ile Ser Gly Gly
            180                 185                 190         
Pro Leu Arg Ser Glu Tyr Gly Thr Pro Thr Lys Ser Pro Pro Ala Ala
        195                 200                 205             
Leu Glu Val Val Pro Cys Ile Pro Ser Pro Ala Ala Pro Ser Asp Lys
    210                 215                 220                 
Ala Pro Ser Glu Gly Glu Ser Ser Gly Asn Ser Asn Ala Gly Ser Ser
225                 230                 235                 240 
Ala Leu Lys Arg Lys Leu Arg Gly Asp Phe Asp Ser Asp Glu Glu Ser
                245                 250                 255     
Leu Gly Tyr Asn Leu Asp Ser Asp Glu Glu Glu Glu Thr Leu Lys Ser
            260                 265                 270         
Leu Glu Glu Ile Met Ala Leu Asn Phe Asn Gln Thr Pro Ala Ala Thr
        275                 280                 285             
Gly Lys Pro Pro Ala Leu Ser Lys Gly Leu Arg Ser Gln Ser Ser Asp
    290                 295                 300                 
Tyr Thr Gly His Val His Pro Gly Thr Tyr Thr Asn Thr Leu Glu Arg
305                 310                 315                 320 
Leu Val Lys Glu Met Glu Asp Thr Gln Arg Phe Val Ser Ile Lys Ile
                325                 330                 335     
Asn Leu Leu Asn Leu Thr Phe Cys Leu Phe Val Trp Leu Thr Phe Asn
            340                 345                 350         
Leu Pro Phe Leu Lys Asn His Glu Lys Leu Ala Cys Ile Leu Asp Ser
        355                 360                 365             
Val Val Asn Cys Val Arg Ile Arg Tyr Val Gly Arg Thr Gln Trp Leu
    370                 375                 380                 
Met Pro Val Ile Thr Thr Leu Trp Glu Thr Gln Ala Arg Leu Leu Glu
385                 390                 395                 400 
Pro Arg Ser Ser Arg Leu Arg
                405         


<210> 8250
<211> 698
<212> PRT
<213> Homo sapiens

<400> 8250
Met Met Arg Ser Arg Ser Lys Ser Pro Arg Arg Pro Ser Pro Thr Ala
 1               5                  10                  15      
Arg Gly Ala Asn Cys Asp Val Glu Leu Leu Lys Thr Thr Thr Arg Asp
            20                  25                  30          
Arg Glu Glu Leu Lys Cys Met Leu Glu Lys Tyr Glu Arg His Leu Ala
        35                  40                  45              
Glu Ile Gln Gly Asn Val Lys Val Leu Lys Ser Glu Arg Asp Lys Ile
    50                  55                  60                  
Phe Leu Leu Tyr Glu Gln Ala Gln Glu Glu Ile Thr Arg Leu Arg Arg
65                  70                  75                  80  
Glu Met Met Lys Ser Cys Lys Ser Pro Lys Ser Thr Thr Ala His Ala
                85                  90                  95      
Ile Leu Arg Arg Val Glu Thr Glu Arg Asp Val Ala Phe Thr Asp Leu
            100                 105                 110         
Arg Arg Met Thr Thr Glu Arg Asp Ser Leu Arg Glu Arg Leu Lys Ile
        115                 120                 125             
Ala Gln Glu Thr Ala Phe Asn Glu Lys Ala His Leu Glu Gln Arg Ile
    130                 135                 140                 
Glu Glu Leu Glu Cys Thr Val His Asn Leu Asp Asp Glu Arg Met Glu
145                 150                 155                 160 
Gln Met Ser Asn Met Thr Leu Met Lys Glu Thr Ile Ser Thr Val Glu
                165                 170                 175     
Lys Glu Met Lys Ser Leu Ala Arg Lys Ala Met Asp Thr Glu Ser Glu
            180                 185                 190         
Leu Gly Arg Gln Lys Ala Glu Asn Asn Ser Leu Arg Leu Leu Tyr Glu
        195                 200                 205             
Asn Thr Glu Lys Asp Leu Ser Asp Thr Gln Arg His Leu Ala Lys Lys
    210                 215                 220                 
Lys Tyr Glu Leu Gln Leu Thr Gln Glu Lys Ile Met Cys Leu Asp Glu
225                 230                 235                 240 
Lys Ile Asp Asn Phe Thr Arg Gln Asn Ile Ala Gln Arg Glu Glu Ile
                245                 250                 255     
Ser Ile Leu Gly Gly Thr Leu Asn Asp Leu Ala Lys Glu Lys Glu Cys
            260                 265                 270         
Leu Gln Ala Cys Leu Asp Lys Lys Ser Glu Asn Ile Ala Ser Leu Gly
        275                 280                 285             
Glu Ser Leu Ala Met Lys Glu Lys Thr Ile Ser Gly Met Lys Asn Ile
    290                 295                 300                 
Ile Ala Glu Met Glu Gln Ala Ser Arg Gln Cys Thr Glu Ala Leu Ile
305                 310                 315                 320 
Val Cys Glu Gln Asp Val Ser Arg Met Arg Arg Gln Leu Asp Glu Thr
                325                 330                 335     
Asn Asp Glu Leu Ala Gln Ile Ala Arg Glu Arg Asp Ile Leu Ala His
            340                 345                 350         
Asp Asn Asp Asn Leu Gln Glu Gln Phe Ala Lys Ala Lys Gln Glu Asn
        355                 360                 365             
Gln Ala Leu Ser Lys Lys Leu Asn Asp Thr His Asn Glu Leu Asn Asp
    370                 375                 380                 
Ile Lys Gln Lys Val Gln Asp Thr Asn Leu Glu Val Asn Lys Leu Lys
385                 390                 395                 400 
Asn Ile Leu Lys Ser Glu Glu Ser Glu Asn Arg Gln Met Met Glu Gln
                405                 410                 415     
Leu Arg Lys Ala Asn Glu Asp Ala Glu Asn Trp Glu Asn Lys Ala Arg
            420                 425                 430         
Gln Ser Glu Ala Asp Asn Asn Thr Leu Lys Leu Glu Leu Ile Thr Ala
        435                 440                 445             
Glu Ala Glu Gly Asn Arg Leu Lys Glu Lys Val Asp Ser Leu Asn Arg
    450                 455                 460                 
Glu Val Glu Gln His Leu Asn Ala Glu Arg Ser Tyr Lys Ser Gln Ile
465                 470                 475                 480 
Ser Thr Leu His Lys Ser Val Val Lys Met Glu Glu Glu Leu Gln Lys
                485                 490                 495     
Val Gln Phe Glu Lys Val Ser Ala Leu Ala Asp Leu Ser Ser Thr Arg
            500                 505                 510         
Glu Leu Cys Ile Lys Leu Asp Ser Ser Lys Glu Leu Leu Asn Arg Gln
        515                 520                 525             
Leu Val Ala Lys Asp Gln Glu Ile Glu Met Arg Glu Asn Glu Leu Asp
    530                 535                 540                 
Ser Ala His Ser Glu Ile Glu Leu Leu Arg Ser Gln Met Ala Asn Glu
545                 550                 555                 560 
Arg Ile Ser Met Gln Asn Leu Glu Ala Leu Leu Val Ala Asn Arg Asp
                565                 570                 575     
Lys Glu Tyr Gln Ser Gln Ile Ala Leu Gln Glu Lys Glu Ser Glu Ile
            580                 585                 590         
Gln Leu Leu Lys Glu His Leu Cys Leu Ala Glu Asn Lys Met Ala Ile
        595                 600                 605             
Gln Ser Arg Asp Val Ala Gln Phe Arg Asn Val Val Thr Gln Leu Glu
    610                 615                 620                 
Ala Asp Leu Asp Ile Thr Lys Arg Gln Leu Gly Thr Glu Arg Phe Glu
625                 630                 635                 640 
Arg Glu Arg Ala Val Gln Glu Leu Arg Arg Gln Asn Tyr Ser Ser Asn
                645                 650                 655     
Ala Tyr His Met Ser Ser Thr Met Lys Pro Asn Thr Lys Cys His Ser
            660                 665                 670         
Pro Glu Arg Ala His His Arg Ser Pro Asp Arg Gly Leu Asp Arg Ser
        675                 680                 685             
Leu Glu Glu Asn Leu Cys Tyr Arg Asp Phe
    690                 695             


<210> 8251
<211> 699
<212> PRT
<213> Homo sapiens

<400> 8251
Met Met Arg Ser Arg Ser Lys Ser Pro Arg Arg Pro Ser Pro Thr Ala
 1               5                  10                  15      
Arg Gly Ala Asn Cys Asp Val Glu Leu Leu Lys Glu Pro Thr Thr Arg
            20                  25                  30          
Asp Arg Glu Glu Leu Lys Cys Met Leu Glu Lys Tyr Glu Arg His Leu
        35                  40                  45              
Ala Glu Ile Gln Gly Asn Val Lys Val Leu Lys Ser Glu Arg Asp Lys
    50                  55                  60                  
Ile Phe Leu Leu Tyr Glu Gln Ala Gln Glu Glu Ile Thr Arg Leu Arg
65                  70                  75                  80  
Arg Glu Met Met Lys Ser Cys Lys Ser Pro Lys Ser Thr Thr Ala His
                85                  90                  95      
Ala Ile Leu Arg Arg Val Glu Thr Glu Arg Asp Val Ala Phe Thr Asp
            100                 105                 110         
Leu Arg Arg Met Thr Thr Glu Arg Asp Ser Leu Arg Glu Arg Leu Lys
        115                 120                 125             
Ile Ala Gln Glu Thr Ala Phe Asn Glu Lys Ala His Leu Glu Gln Arg
    130                 135                 140                 
Ile Glu Glu Leu Glu Cys Thr Val His Asn Leu Asp Asp Glu Arg Met
145                 150                 155                 160 
Glu Gln Met Ser Asn Met Thr Leu Met Lys Glu Thr Ile Ser Thr Val
                165                 170                 175     
Glu Lys Glu Met Lys Ser Leu Ala Arg Lys Ala Met Asp Thr Glu Ser
            180                 185                 190         
Glu Leu Gly Arg Gln Lys Ala Glu Asn Asn Ser Leu Arg Leu Leu Tyr
        195                 200                 205             
Glu Asn Thr Glu Lys Asp Leu Ser Asp Thr Gln Arg His Leu Ala Lys
    210                 215                 220                 
Lys Lys Tyr Glu Leu Gln Leu Thr Gln Glu Lys Ile Met Cys Leu Asp
225                 230                 235                 240 
Glu Lys Ile Asp Asn Phe Thr Arg Gln Asn Ile Ala Gln Arg Glu Glu
                245                 250                 255     
Ile Ser Ile Leu Gly Gly Thr Leu Asn Asp Leu Ala Lys Glu Lys Glu
            260                 265                 270         
Cys Leu Gln Ala Cys Leu Asp Lys Lys Ser Glu Asn Ile Ala Ser Leu
        275                 280                 285             
Gly Glu Ser Leu Ala Met Lys Glu Lys Thr Ile Ser Gly Met Lys Asn
    290                 295                 300                 
Ile Ile Ala Glu Met Glu Gln Ala Ser Arg Gln Cys Thr Glu Ala Leu
305                 310                 315                 320 
Ile Val Cys Glu Gln Asp Val Ser Arg Met Arg Arg Gln Leu Asp Glu
                325                 330                 335     
Thr Asn Asp Glu Leu Ala Gln Ile Ala Arg Glu Arg Asp Ile Leu Ala
            340                 345                 350         
His Asp Asn Asp Asn Leu Gln Glu Gln Phe Ala Lys Ala Asn Gln Glu
        355                 360                 365             
Asn Gln Ala Leu Ser Lys Lys Leu Asn Asp Thr His Asn Glu Leu Asn
    370                 375                 380                 
Asp Ile Lys Gln Lys Val Gln Asp Thr Asn Leu Glu Val Asn Lys Leu
385                 390                 395                 400 
Lys Asn Ile Leu Lys Ser Glu Glu Ser Glu Asn Arg Gln Met Met Glu
                405                 410                 415     
Gln Leu Arg Lys Ala Asn Glu Asp Ala Glu Asn Trp Glu Asn Lys Ala
            420                 425                 430         
Arg Gln Ser Glu Ala Asp Asn Asn Thr Leu Lys Leu Glu Leu Ile Thr
        435                 440                 445             
Ala Glu Ala Glu Gly Asn Arg Leu Lys Glu Lys Val Asp Ser Leu Asn
    450                 455                 460                 
Arg Glu Val Glu Gln His Leu Asn Ala Glu Arg Ser Tyr Lys Ser Gln
465                 470                 475                 480 
Ile Ser Thr Leu His Lys Ser Val Val Lys Met Glu Glu Glu Leu Gln
                485                 490                 495     
Lys Val Gln Phe Glu Lys Val Ser Ala Leu Ala Asp Leu Ser Ser Thr
            500                 505                 510         
Arg Glu Leu Cys Ile Lys Leu Asp Ser Ser Lys Glu Leu Leu Asn Arg
        515                 520                 525             
Gln Leu Val Ala Lys Asp Gln Glu Ile Glu Met Arg Glu Asn Glu Leu
    530                 535                 540                 
Asp Ser Ala His Ser Glu Ile Glu Leu Leu Arg Ser Gln Met Ala Asn
545                 550                 555                 560 
Glu Arg Ile Ser Met Gln Asn Leu Glu Ala Leu Leu Val Ala Asn Arg
                565                 570                 575     
Asp Lys Glu Tyr Gln Ser Gln Ile Ala Leu Gln Glu Lys Glu Ser Glu
            580                 585                 590         
Ile Gln Leu Leu Lys Glu His Leu Cys Leu Ala Glu Asn Lys Met Ala
        595                 600                 605             
Ile Gln Ser Arg Asp Val Ala Gln Phe Arg Asn Val Val Thr Gln Leu
    610                 615                 620                 
Gly Ala Asp Leu Asp Ile Thr Lys Arg Gln Leu Gly Thr Glu Arg Phe
625                 630                 635                 640 
Glu Arg Glu Arg Ala Val Gln Glu Leu Arg Arg Gln Asn Tyr Ser Ser
                645                 650                 655     
Asn Ala Tyr His Met Ser Ser Thr Met Lys Pro Asn Thr Lys Cys His
            660                 665                 670         
Ser Pro Glu Arg Ala His His Arg Ser Pro Asp Arg Gly Leu Asp Arg
        675                 680                 685             
Ser Leu Glu Glu Asn Leu Cys Tyr Arg Asp Phe
    690                 695                 


<210> 8252
<211> 5596
<212> PRT
<213> Homo sapiens

<400> 8252
Met Glu His Phe Leu Leu Glu Val Ala Ala Ala Pro Leu Arg Leu Ile
 1               5                  10                  15      
Ala Ala Lys Asn Glu Lys Ser Arg Ser Glu Leu Gly Arg Phe Leu Ala
            20                  25                  30          
Lys Gln Val Trp Thr Pro Gln Asp Arg Gln Cys Val Leu Ser Thr Leu
        35                  40                  45              
Ala Gln Leu Leu Leu Asp Lys Asp Cys Thr Val Leu Val Gly Arg Gln
    50                  55                  60                  
Leu Arg Pro Leu Leu Leu Asp Leu Leu Glu Arg Asn Ala Glu Ala Ile
65                  70                  75                  80  
Lys Ala Gly Gly Gln Ile Asn His Asp Leu His Glu Arg Leu Cys Val
                85                  90                  95      
Ser Met Ser Lys Leu Ile Gly Asn His Pro Asp Val Leu Pro Phe Ala
            100                 105                 110         
Leu Arg Tyr Phe Lys Asp Thr Ser Pro Val Phe Gln Arg Leu Phe Leu
        115                 120                 125             
Glu Ser Ser Asp Ala Asn Pro Val Arg Tyr Gly Arg Arg Arg Met Lys
    130                 135                 140                 
Leu Arg Asp Leu Met Glu Ala Ala Phe Lys Phe Leu Gln Gln Glu Gln
145                 150                 155                 160 
Ser Val Phe Arg Glu Leu Trp Asp Trp Ser Val Cys Val Pro Leu Leu
                165                 170                 175     
Arg Ser His Asp Thr Leu Val Arg Trp Tyr Thr Ala Asn Cys Leu Ala
            180                 185                 190         
Leu Val Thr Cys Met Asn Glu Glu His Lys Leu Ser Phe Leu Lys Lys
        195                 200                 205             
Ile Phe Asn Ser Asp Glu Leu Ile His Phe Arg Leu Arg Leu Leu Glu
    210                 215                 220                 
Glu Ala Gln Leu Gln Asp Leu Glu Lys Ala Leu Val Leu Ala Asn Pro
225                 230                 235                 240 
Glu Val Ser Leu Trp Arg Lys Gln Lys Glu Leu Gln Tyr Leu Gln Gly
                245                 250                 255     
His Leu Val Ser Ser Asp Leu Ser Pro Arg Val Thr Ala Val Cys Gly
            260                 265                 270         
Val Val Leu Pro Gly Gln Leu Pro Ala Pro Gly Glu Leu Gly Gly Asn
        275                 280                 285             
Arg Ser Ser Ser Arg Glu Gln Glu Leu Ala Leu Arg Ser Tyr Val Leu
    290                 295                 300                 
Val Glu Ser Val Cys Lys Ser Leu Gln Thr Leu Ala Met Ala Val Ala
305                 310                 315                 320 
Ser Gln Asn Ala Val Leu Leu Glu Gly Pro Ile Gly Cys Gly Lys Thr
                325                 330                 335     
Ser Leu Val Glu Tyr Leu Ala Ala Val Thr Gly Arg Thr Lys Pro Pro
            340                 345                 350         
Gln Leu Leu Lys Val Gln Leu Gly Asp Gln Thr Asp Ser Lys Met Leu
        355                 360                 365             
Leu Gly Met Tyr Arg Cys Thr Asp Val Pro Gly Glu Phe Val Trp Gln
    370                 375                 380                 
Pro Gly Thr Leu Thr Gln Ala Ala Thr Met Gly His Trp Ile Leu Leu
385                 390                 395                 400 
Glu Asp Ile Asp Tyr Ala Pro Leu Asp Val Val Ser Val Leu Ile Pro
                405                 410                 415     
Leu Leu Glu Asn Gly Glu Leu Leu Ile Pro Gly Arg Gly Asp Cys Leu
            420                 425                 430         
Lys Val Ala Pro Gly Phe Gln Phe Phe Ala Thr Arg Arg Leu Leu Ser
        435                 440                 445             
Cys Gly Gly Asn Trp Tyr Arg Pro Leu Asn Ser His Ala Thr Leu Leu
    450                 455                 460                 
Asp Lys Tyr Trp Thr Lys Ile His Leu Asp Asn Leu Asp Lys Arg Glu
465                 470                 475                 480 
Leu Asn Glu Val Leu Gln Ser Arg Tyr Pro Ser Leu Leu Ala Val Val
                485                 490                 495     
Asp His Leu Leu Asp Ile Tyr Ile Gln Leu Thr Gly Glu Lys His His
            500                 505                 510         
Ser Trp Ser Asp Ser Ser Val Gly Cys Glu Gln Ala Pro Glu Glu Val
        515                 520                 525             
Ser Glu Ala Arg Arg Glu Asn Lys Arg Pro Thr Leu Glu Gly Arg Glu
    530                 535                 540                 
Leu Ser Leu Arg Asp Leu Leu Asn Trp Cys Asn Arg Ile Ala His Ser
545                 550                 555                 560 
Phe Asp Ser Ser Ser Leu Ser Ala Ser Leu Asn Ile Phe Gln Glu Ala
                565                 570                 575     
Leu Asp Cys Phe Thr Ala Met Leu Ser Glu His Thr Ser Lys Leu Lys
            580                 585                 590         
Met Ala Glu Val Ile Gly Ser Lys Leu Asn Ile Ser Arg Lys Lys Ala
        595                 600                 605             
Glu Phe Phe Cys Gln Leu Tyr Lys Pro Glu Ile Val Ile Asn Glu Leu
    610                 615                 620                 
Asp Leu Gln Val Gly Arg Val Arg Leu Leu Arg Lys Gln Ser Glu Ala
625                 630                 635                 640 
Val His Leu Gln Arg Glu Lys Phe Thr Phe Ala Ala Thr Arg Pro Ser
                645                 650                 655     
Ser Val Leu Ile Glu Gln Leu Ala Val Cys Val Ser Lys Gly Glu Pro
            660                 665                 670         
Val Leu Leu Val Gly Glu Thr Gly Thr Gly Lys Thr Ser Thr Ile Gln
        675                 680                 685             
Tyr Leu Ala His Ile Thr Gly His Arg Leu Arg Val Val Asn Met Asn
    690                 695                 700                 
Gln Gln Ser Asp Thr Ala Asp Leu Leu Gly Gly Tyr Lys Pro Val Asp
705                 710                 715                 720 
His Lys Leu Ile Trp Leu Pro Leu Arg Glu Ala Phe Glu Glu Leu Phe
                725                 730                 735     
Ala Gln Thr Phe Ser Lys Lys Gln Asn Phe Thr Phe Leu Gly His Ile
            740                 745                 750         
Gln Thr Cys Tyr Arg Gln Lys Arg Trp His Asp Leu Leu Arg Leu Met
        755                 760                 765             
Gln His Val His Lys Ser Ala Val Asn Lys Asp Gly Lys Asp Ser Glu
    770                 775                 780                 
Thr Gly Leu Leu Ile Lys Glu Lys Trp Glu Ala Phe Gly Leu Arg Leu
785                 790                 795                 800 
Asn His Ala Gln Gln Gln Met Lys Met Thr Glu Asn Thr Leu Leu Phe
                805                 810                 815     
Ala Phe Val Glu Gly Thr Leu Ala Gln Ala Val Lys Lys Gly Glu Trp
            820                 825                 830         
Ile Leu Leu Asp Glu Ile Asn Leu Ala Ala Pro Glu Ile Leu Glu Cys
        835                 840                 845             
Leu Ser Gly Leu Leu Glu Gly Ser Ser Gly Ser Leu Val Leu Leu Asp
    850                 855                 860                 
Arg Gly Asp Thr Glu Pro Leu Val Arg His Pro Asp Phe Arg Leu Phe
865                 870                 875                 880 
Ala Cys Met Asn Pro Ala Thr Asp Val Gly Lys Arg Asn Leu Pro Pro
                885                 890                 895     
Gly Ile Arg Asn Arg Phe Thr Glu Leu Tyr Val Glu Glu Leu Glu Ser
            900                 905                 910         
Lys Glu Asp Leu Gln Val Leu Ile Val Asp Tyr Leu Lys Gly Leu Ser
        915                 920                 925             
Val Asn Lys Asn Thr Val Gln Gly Ile Ile Asn Phe Tyr Thr Ala Leu
    930                 935                 940                 
Arg Lys Glu Ser Gly Thr Lys Leu Val Asp Gly Thr Gly His Arg Pro
945                 950                 955                 960 
His Tyr Ser Leu Arg Thr Leu Cys Arg Ala Leu Arg Phe Ala Ala Ser
                965                 970                 975     
Asn Pro Cys Gly Asn Ile Gln Arg Ser Leu Tyr Glu Gly Phe Cys Leu
            980                 985                 990         
Gly Phe Leu Thr Gln Leu Asp Arg Ala Ser His Pro Ile Val Gln Lys
        995                 1000                1005            
Leu Ile Cys Gln His Ile Val Pro Gly Asn Val Lys Ser Leu Leu Lys
    1010                1015                1020                
Gln Pro Ile Pro Glu Pro Lys Gly Gly Arg Leu Ile Gln Val Glu Gly
1025                1030                1035                1040
Tyr Trp Ile Ala Val Gly Asp Lys Glu Pro Thr Ile Asp Glu Thr Tyr
                1045                1050                1055    
Ile Leu Thr Ser Ser Val Lys Leu Asn Leu Arg Asp Ile Val Arg Val
            1060                1065                1070        
Val Ser Ala Gly Thr Tyr Pro Val Leu Ile Gln Gly Glu Thr Ser Val
        1075                1080                1085            
Gly Lys Thr Ser Leu Ile Gln Trp Leu Ala Ala Ala Thr Gly Asn His
    1090                1095                1100                
Cys Val Arg Ile Asn Asn His Glu His Thr Asp Ile Gln Glu Tyr Ile
1105                1110                1115                1120
Gly Cys Tyr Thr Ser Asp Ser Ser Gly Lys Leu Val Phe Lys Glu Gly
                1125                1130                1135    
Val Leu Ile Asp Ala Met Arg Lys Gly Tyr Trp Ile Ile Leu Asp Glu
            1140                1145                1150        
Leu Asn Leu Ala Pro Thr Asp Val Leu Glu Ala Leu Asn Arg Leu Leu
        1155                1160                1165            
Asp Asp Asn Arg Glu Leu Leu Val Thr Glu Thr Gln Glu Val Val Lys
    1170                1175                1180                
Ala His Pro Arg Phe Met Leu Phe Ala Thr Gln Asn Pro Pro Gly Leu
1185                1190                1195                1200
Tyr Gly Gly Arg Lys Val Leu Ser Arg Ala Phe Arg Asn Arg Phe Val
                1205                1210                1215    
Glu Leu His Phe Asp Glu Leu Pro Ser Ser Glu Leu Glu Thr Ile Leu
            1220                1225                1230        
His Lys Arg Cys Ser Leu Pro Pro Ser Tyr Cys Ser Lys Leu Val Lys
        1235                1240                1245            
Val Met Leu Asp Leu Gln Ser Tyr Arg Arg Ser Ser Ser Val Phe Ala
    1250                1255                1260                
Gly Lys Gln Gly Phe Ile Thr Leu Arg Asp Leu Phe Arg Trp Ala Glu
1265                1270                1275                1280
Arg Tyr Arg Leu Ala Glu Pro Thr Glu Lys Glu Tyr Asp Trp Leu Gln
                1285                1290                1295    
His Leu Ala Asn Asp Gly Tyr Met Leu Leu Ala Gly Arg Val Arg Lys
            1300                1305                1310        
Gln Glu Glu Ile Asp Val Ile Gln Glu Val Leu Glu Lys His Phe Lys
        1315                1320                1325            
Lys Lys Leu Cys Pro Gln Ser Leu Phe Ser Lys Glu Asn Val Leu Lys
    1330                1335                1340                
Leu Leu Gly Lys Leu Ser Thr Gln Ile Ser Thr Leu Glu Cys Asn Phe
1345                1350                1355                1360
Gly His Ile Val Trp Thr Glu Gly Met Arg Arg Leu Ala Met Leu Val
                1365                1370                1375    
Gly Arg Ala Leu Glu Phe Gly Glu Pro Val Leu Leu Val Gly Asp Thr
            1380                1385                1390        
Gly Cys Gly Lys Thr Thr Ile Cys Gln Val Phe Ala Ala Leu Ala Asn
        1395                1400                1405            
Gln Lys Leu Tyr Ser Val Ser Cys His Leu His Met Glu Thr Ser Asp
    1410                1415                1420                
Phe Leu Gly Gly Leu Arg Pro Val Arg Gln Lys Pro Asn Asp Lys Glu
1425                1430                1435                1440
Glu Ile Asp Thr Ser Arg Leu Phe Glu Trp His Asp Gly Pro Leu Val
                1445                1450                1455    
Gln Ala Met Lys Glu Asp Gly Phe Phe Leu Leu Asp Glu Ile Ser Leu
            1460                1465                1470        
Ala Asp Asp Ser Val Leu Glu Arg Leu Asn Ser Val Leu Glu Val Glu
        1475                1480                1485            
Lys Ser Leu Val Leu Ala Glu Lys Gly Ser Pro Glu Asp Lys Asp Ser
    1490                1495                1500                
Glu Ile Glu Leu Leu Thr Ala Gly Lys Lys Phe Arg Ile Leu Ala Thr
1505                1510                1515                1520
Met Asn Pro Gly Gly Asp Phe Gly Lys Lys Glu Leu Ser Pro Ala Leu
                1525                1530                1535    
Arg Asn Arg Phe Thr Glu Ile Trp Cys Pro Gln Ser Thr Ser Arg Glu
            1540                1545                1550        
Asp Leu Ile Gln Ile Ile Ser His Asn Leu Arg Pro Gly Leu Cys Leu
        1555                1560                1565            
Gly Arg Ile Asp Pro Lys Gly Ser Asp Ile Pro Glu Val Met Leu Asp
    1570                1575                1580                
Phe Ile Asp Trp Leu Thr His Gln Glu Phe Gly Arg Lys Cys Val Val
1585                1590                1595                1600
Ser Ile Arg Asp Ile Leu Ser Trp Val Asn Phe Met Asn Lys Met Gly
                1605                1610                1615    
Glu Glu Ala Ala Leu Lys Arg Pro Glu Ile Ile Ser Thr Val Thr Ser
            1620                1625                1630        
Phe Val His Ala Ala Cys Leu Val Tyr Ile Asp Gly Ile Gly Ser Gly
        1635                1640                1645            
Val Thr Ser Ser Gly Phe Gly Thr Ala Leu Leu Ala Arg Lys Glu Cys
    1650                1655                1660                
Leu Lys Phe Leu Ile Lys Arg Leu Ala Lys Ile Val Arg Leu Thr Glu
1665                1670                1675                1680
Tyr Gln Lys Asn Glu Leu Lys Ile Tyr Asp Arg Met Lys Ala Lys Glu
                1685                1690                1695    
Phe Thr Gly Ile Asp Asn Leu Trp Gly Ile His Pro Phe Phe Ile Pro
            1700                1705                1710        
Arg Gly Pro Val Leu His Arg Asn Asn Ile Ala Asp Tyr Ala Leu Ser
        1715                1720                1725            
Ala Gly Thr Thr Ala Met Asn Ala Gln Arg Leu Leu Arg Ala Thr Lys
    1730                1735                1740                
Leu Lys Lys Pro Ile Leu Leu Glu Gly Ser Pro Gly Val Gly Lys Thr
1745                1750                1755                1760
Ser Leu Val Gly Ala Leu Ala Lys Ala Ser Gly Asn Thr Leu Val Arg
                1765                1770                1775    
Ile Asn Leu Ser Glu Gln Thr Asp Ile Thr Asp Leu Phe Gly Ala Asp
            1780                1785                1790        
Leu Pro Val Glu Gly Gly Lys Gly Gly Glu Phe Ala Trp Arg Asp Gly
        1795                1800                1805            
Pro Leu Leu Ala Ala Leu Lys Ala Gly His Trp Val Val Leu Asp Glu
    1810                1815                1820                
Leu Asn Leu Ala Ser Gln Ser Val Leu Glu Gly Leu Asn Ala Cys Phe
1825                1830                1835                1840
Asp His Arg Gly Glu Ile Tyr Val Pro Glu Leu Gly Met Ser Phe Gln
                1845                1850                1855    
Val Gln His Glu Lys Thr Lys Ile Phe Gly Cys Gln Asn Pro Phe Arg
            1860                1865                1870        
Gln Gly Gly Gly Arg Lys Gly Leu Pro Arg Ser Phe Leu Asn Arg Phe
        1875                1880                1885            
Thr Gln Val Phe Val Asp Pro Leu Thr Val Ile Asp Met Glu Phe Ile
    1890                1895                1900                
Ala Ser Thr Leu Phe Pro Ala Ile Glu Lys Asn Ile Val Lys Lys Met
1905                1910                1915                1920
Val Ala Phe Asn Asn Gln Ile Asp His Glu Val Thr Val Glu Lys Lys
                1925                1930                1935    
Trp Gly Gln Lys Gly Gly Pro Trp Glu Phe Asn Leu Arg Asp Leu Phe
            1940                1945                1950        
Arg Trp Cys Gln Leu Met Leu Val Asp Gln Ser Pro Gly Cys Tyr Asp
        1955                1960                1965            
Pro Gly Gln His Val Phe Leu Val Tyr Gly Glu Arg Met Arg Thr Glu
    1970                1975                1980                
Glu Asp Lys Lys Lys Val Ile Ala Val Phe Lys Asp Val Phe Gly Ser
1985                1990                1995                2000
Asn Ser Asn Pro Tyr Met Gly Thr Arg Leu Phe Arg Ile Thr Pro Tyr
                2005                2010                2015    
Asp Val Gln Leu Gly Tyr Ser Val Leu Ser Arg Gly Ser Cys Val Pro
            2020                2025                2030        
His Pro Ser Arg His Pro Leu Leu Leu Leu His Gln Ser Phe Gln Pro
        2035                2040                2045            
Leu Glu Ser Ile Met Lys Cys Val Gln Met Ser Trp Met Val Ile Leu
    2050                2055                2060                
Val Gly Pro Ala Ser Val Gly Lys Thr Ser Leu Val Gln Leu Leu Ala
2065                2070                2075                2080
His Leu Thr Gly His Thr Leu Lys Ile Met Ala Met Asn Ser Ala Met
                2085                2090                2095    
Asp Thr Thr Glu Leu Leu Gly Gly Phe Glu Gln Val Asp Leu Ile Arg
            2100                2105                2110        
Pro Trp Arg Arg Leu Leu Glu Lys Val Glu Gly Thr Val Arg Ala Leu
        2115                2120                2125            
Leu Arg Asp Ser Leu Leu Ile Ser Ala Asp Asp Ala Glu Val Val Leu
    2130                2135                2140                
Arg Ala Trp Ser His Phe Leu Leu Thr Tyr Lys Pro Lys Cys Leu Gly
2145                2150                2155                2160
Glu Gly Gly Lys Ala Ile Thr Met Glu Ile Val Asn Lys Leu Glu Ala
                2165                2170                2175    
Val Leu Leu Leu Met Gln Arg Leu Asn Asn Lys Ile Asn Ser Tyr Cys
            2180                2185                2190        
Lys Ala Glu Phe Ala Lys Leu Val Glu Glu Phe Arg Ser Phe Gly Val
        2195                2200                2205            
Lys Leu Thr Gln Leu Ala Ser Gly His Ser His Gly Thr Phe Glu Trp
    2210                2215                2220                
Val Asp Ser Met Leu Val Gln Ala Leu Lys Ser Gly Asp Trp Leu Leu
2225                2230                2235                2240
Met Asp Asn Val Asn Phe Cys Asn Pro Ser Val Leu Asp Arg Leu Asn
                2245                2250                2255    
Ala Leu Leu Glu Pro Gly Gly Val Leu Thr Ile Ser Glu Arg Gly Met
            2260                2265                2270        
Ile Asp Gly Ser Thr Pro Thr Ile Thr Pro Asn Pro Asn Phe Arg Leu
        2275                2280                2285            
Phe Leu Ser Met Asp Pro Val His Gly Asp Ile Ser Arg Ala Met Arg
    2290                2295                2300                
Asn Arg Gly Leu Glu Ile Tyr Ile Ser Gly Glu Gly Asp Ala Ser Thr
2305                2310                2315                2320
Pro Asp Asn Leu Asp Leu Lys Val Leu Leu His Ser Leu Gly Leu Val
                2325                2330                2335    
Gly Asn Ser Val Cys Asp Ile Leu Leu Ala Leu His Thr Glu Thr Arg
            2340                2345                2350        
Ser Thr Val Val Gly Ser Pro Thr Ser Ser Val Ser Thr Leu Ile Gln
        2355                2360                2365            
Thr Ala Ile Leu Ile Val Gln Tyr Leu Gln Arg Gly Leu Ser Leu Asp
    2370                2375                2380                
Arg Ala Phe Ser Glu Ala Cys Trp Glu Val Tyr Val Cys Ser Gln His
2385                2390                2395                2400
Ser Pro Ala Asn Arg Lys Leu Val Gln Ala Leu Leu Glu Lys His Val
                2405                2410                2415    
Ser Ser Leu Arg Ala His Glu Thr Trp Gly Asp Ser Ile Leu Gly Met
            2420                2425                2430        
Gly Leu Trp Pro Asp Ser Val Pro Ser Ala Leu Phe Ala Thr Glu Asp
        2435                2440                2445            
Ser His Leu Ser Thr Val Arg Arg Asp Gly Gln Ile Leu Val Tyr Cys
    2450                2455                2460                
Leu Asn Arg Met Ser Met Lys Thr Ser Ser Trp Thr Arg Ser Gln Pro
2465                2470                2475                2480
Phe Thr Leu Gln Asp Leu Glu Lys Ile Met Gln Ser Pro Ser Pro Glu
                2485                2490                2495    
Asn Leu Lys Phe Asn Ala Val Glu Val Asn Thr Tyr Trp Ile Asp Glu
            2500                2505                2510        
Pro Asp Val Leu Val Met Ala Val Lys Leu Leu Ile Glu Arg Ala Thr
        2515                2520                2525            
Asn Gln Asp Trp Met Leu Arg Val Lys Trp Leu Tyr His Leu Ala Lys
    2530                2535                2540                
Asn Ile Pro Gln Gly Leu Glu Ser Ile Gln Ile His Leu Glu Ala Ser
2545                2550                2555                2560
Ala Ala Ser Leu Arg Asn Phe Tyr Ser His Ser Leu Ser Gly Ala Val
                2565                2570                2575    
Ser Asn Val Phe Lys Ile Leu Gln Pro Asn Thr Thr Asp Glu Phe Val
            2580                2585                2590        
Ile Pro Leu Asp Pro Arg Trp Asn Met Gln Ala Leu Asp Met Ile Arg
        2595                2600                2605            
Asn Leu Met Asp Phe Asp Pro Gln Thr Asp Gln Pro Asp Gln Leu Phe
    2610                2615                2620                
Ala Leu Leu Glu Ser Ala Ala Asn Lys Thr Ile Ile Tyr Leu Asp Arg
2625                2630                2635                2640
Glu Lys Arg Val Phe Thr Glu Ala Asn Leu Val Ser Val Gly Ser Lys
                2645                2650                2655    
Lys Leu Arg Glu Ser Val Leu Arg Met Ser Phe Glu Phe His Gln Asp
            2660                2665                2670        
Pro Glu Ser Tyr His Thr Leu Pro His Glu Ile Val Val Asn Leu Ala
        2675                2680                2685            
Ala Phe Phe Glu Leu Cys Asp Ala Leu Val Leu Leu Trp Val Gln Ser
    2690                2695                2700                
Ser Gln Gly Met Val Ser Asp Ala Ser Ala Asn Glu Ile Leu Gly Ser
2705                2710                2715                2720
Leu Arg Trp Arg Asp Arg Phe Trp Thr Val Ala Asp Thr Val Lys Val
                2725                2730                2735    
Asp Ala Pro Gly Leu Ala Leu Leu Ala Leu His Trp His Trp Val Leu
            2740                2745                2750        
Lys His Leu Val His Gln Ile Pro Arg Leu Leu Met Asn Tyr Glu Asp
        2755                2760                2765            
Lys Tyr Tyr Lys Glu Val Gln Thr Val Ser Glu His Ile Gln Asn Cys
    2770                2775                2780                
Leu Gly Ser Gln Thr Gly Gly Phe Ala Gly Ile Lys Lys Leu Gln Lys
2785                2790                2795                2800
Phe Leu Gly Arg Pro Phe Pro Phe Lys Asp Lys Leu Val Val Glu Cys
                2805                2810                2815    
Phe Ser Gln Leu Lys Val Leu Asn Lys Val Leu Ala Ile Arg Glu Gln
            2820                2825                2830        
Met Ser Ala Leu Gly Glu Ser Gly Trp Gln Glu Asp Ile Asn Arg Leu
        2835                2840                2845            
Gln Val Val Ala Ser Gln Trp Thr Leu Lys Lys Ser Leu Leu Gln Ala
    2850                2855                2860                
Trp Gly Leu Ile Leu Arg Ala Asn Ile Leu Glu Asp Val Ser Leu Asp
2865                2870                2875                2880
Glu Leu Lys Asn Phe Val His Ala Gln Cys Leu Glu Leu Lys Ala Lys
                2885                2890                2895    
Gly Leu Ser Leu Gly Phe Leu Glu Lys Lys His Asp Glu Ala Ser Ser
            2900                2905                2910        
Leu Ser His Pro Asp Leu Thr Ser Val Ile His Leu Thr Arg Ser Val
        2915                2920                2925            
Gln Leu Trp Pro Ala Met Glu Tyr Leu Ala Met Leu Trp Arg Tyr Lys
    2930                2935                2940                
Val Thr Ala Asp Phe Met Ala Gln Ala Cys Leu Arg Arg Cys Ser Lys
2945                2950                2955                2960
Asn Gln Gln Pro Gln Ile Asn Glu Glu Ile Ser His Leu Ile Ser Phe
                2965                2970                2975    
Cys Leu Tyr His Thr Pro Val Thr Pro Gln Glu Leu Arg Asp Leu Trp
            2980                2985                2990        
Ser Leu Leu His His Gln Lys Val Ser Pro Glu Glu Ile Thr Ser Leu
        2995                3000                3005            
Trp Ser Glu Leu Phe Asn Ser Met Phe Met Ser Phe Trp Ser Ser Thr
    3010                3015                3020                
Val Thr Thr Asn Pro Glu Tyr Trp Leu Met Trp Asn Pro Leu Pro Gly
3025                3030                3035                3040
Met Gln Gln Arg Glu Ala Pro Lys Ser Val Leu Asp Ser Thr Leu Lys
                3045                3050                3055    
Gly Pro Gly Asn Leu Asn Arg Pro Ile Phe Ser Lys Cys Cys Phe Glu
            3060                3065                3070        
Val Leu Thr Ser Ser Trp Arg Ala Ser Pro Trp Asp Val Ser Gly Leu
        3075                3080                3085            
Pro Ile Leu Ser Ser Ser His Val Thr Leu Gly Glu Trp Val Glu Arg
    3090                3095                3100                
Thr Gln Gln Leu Gln Asp Ile Ser Ser Met Leu Trp Thr Asn Met Ala
3105                3110                3115                3120
Ile Ser Ser Val Ala Glu Phe Arg Arg Thr Asp Ser Gln Leu Gln Gly
                3125                3130                3135    
Gln Val Leu Phe Arg His Leu Ala Gly Leu Ala Glu Leu Leu Pro Glu
            3140                3145                3150        
Ser Arg Arg Gln Glu Tyr Met Gln Asn Cys Glu Gln Leu Leu Leu Gly
        3155                3160                3165            
Ser Ser Gln Ala Phe Gln His Val Gly Gln Thr Leu Gly Asp Met Ala
    3170                3175                3180                
Gly Gln Glu Val Leu Pro Lys Glu Leu Leu Cys Gln Leu Leu Thr Ser
3185                3190                3195                3200
Leu His His Phe Val Gly Glu Gly Glu Ser Lys Arg Ser Leu Pro Glu
                3205                3210                3215    
Pro Ala Gln Arg Gly Ser Leu Trp Val Ser Leu Gly Leu Leu Gln Ile
            3220                3225                3230        
Gln Thr Trp Leu Pro Gln Ala Arg Phe Asp Pro Ala Val Lys Arg Glu
        3235                3240                3245            
Tyr Lys Leu Asn Tyr Val Lys Glu Glu Leu His Gln Leu Gln Cys Glu
    3250                3255                3260                
Trp Lys Thr Arg Asn Leu Ser Ser Gln Leu Gln Thr Gly Arg Asp Leu
3265                3270                3275                3280
Glu Asp Glu Val Val Val Ser Tyr Ser His Pro His Val Arg Leu Leu
                3285                3290                3295    
Arg Gln Arg Met Asp Arg Leu Asp Asn Leu Thr Cys His Leu Leu Lys
            3300                3305                3310        
Lys Gln Ala Phe Arg Pro Gln Leu Pro Ala Tyr Glu Ser Leu Val Gln
        3315                3320                3325            
Glu Ile His His Tyr Val Thr Ser Ile Ala Lys Ala Pro Ala Val Gln
    3330                3335                3340                
Asp Leu Leu Thr Arg Leu Leu Gln Ala Leu His Ile Asp Gly Pro Arg
3345                3350                3355                3360
Ser Ala Gln Val Ala Gln Ser Leu Leu Lys Glu Glu Ala Ser Trp Gln
                3365                3370                3375    
Gln Ser His His Gln Phe Arg Lys Arg Leu Ser Glu Glu Tyr Thr Phe
            3380                3385                3390        
Tyr Pro Asp Ala Val Ser Pro Leu Gln Ala Ser Ile Leu Gln Leu Gln
        3395                3400                3405            
His Gly Met Arg Leu Val Ala Ser Glu Leu His Thr Ser Leu His Ser
    3410                3415                3420                
Ser Met Val Gly Ala Asp Arg Leu Gly Thr Leu Ala Thr Ala Leu Leu
3425                3430                3435                3440
Ala Phe Pro Ser Val Gly Pro Thr Phe Pro Thr Tyr Tyr Ala His Ala
                3445                3450                3455    
Asp Thr Leu Cys Ser Val Lys Ser Glu Glu Val Leu Arg Gly Leu Gly
            3460                3465                3470        
Lys Leu Ile Leu Lys Arg Ser Gly Gly Lys Glu Leu Glu Gly Lys Gly
        3475                3480                3485            
Gln Lys Ala Cys Pro Thr Arg Glu Gln Leu Leu Met Asn Ala Leu Leu
    3490                3495                3500                
Tyr Leu Arg Ser His Val Leu Cys Lys Gly Glu Leu Asp Gln Arg Ala
3505                3510                3515                3520
Leu Gln Leu Phe Arg His Val Cys Gln Glu Ile Ile Ser Glu Trp Asp
                3525                3530                3535    
Glu Gln Glu Arg Ile Ala Gln Glu Lys Ala Glu Gln Glu Ser Gly Leu
            3540                3545                3550        
Tyr Arg Tyr Arg Ser Arg Asn Ser Arg Thr Ala Leu Ser Glu Glu Glu
        3555                3560                3565            
Glu Glu Glu Arg Glu Phe Arg Lys Gln Phe Pro Leu His Glu Lys Asp
    3570                3575                3580                
Phe Ala Asp Ile Leu Val Gln Pro Thr Leu Glu Glu Asn Lys Gly Thr
3585                3590                3595                3600
Ser Asp Gly Gln Glu Glu Glu Ala Gly Thr Asn Pro Ala Leu Leu Ser
                3605                3610                3615    
Gln Asn Ser Met Gln Ala Val Met Leu Ile His Gln Gln Leu Cys Leu
            3620                3625                3630        
Asn Phe Ala Arg Ser Leu Trp Tyr Gln Gln Thr Leu Pro Pro His Glu
        3635                3640                3645            
Ala Lys His Tyr Leu Ser Leu Phe Leu Ser Cys Tyr Gln Thr Gly Ala
    3650                3655                3660                
Ser Leu Val Thr His Phe Tyr Pro Leu Met Gly Val Glu Leu Asn Asp
3665                3670                3675                3680
Arg Leu Leu Gly Ser Gln Leu Leu Ala Cys Thr Leu Ser His Asn Thr
                3685                3690                3695    
Leu Phe Gly Glu Ala Pro Ser Asp Leu Met Val Lys Pro Asp Gly Pro
            3700                3705                3710        
Tyr Asp Phe Tyr Gln His Pro Asn Val Pro Glu Ala Arg Gln Cys Gln
        3715                3720                3725            
Pro Val Leu Gln Gly Phe Ser Glu Ala Val Ser His Leu Leu Gln Asp
    3730                3735                3740                
Trp Pro Glu His Pro Ala Leu Glu Gln Leu Leu Val Val Met Asp Arg
3745                3750                3755                3760
Ile Arg Ser Phe Pro Leu Ser Ser Pro Ile Ser Lys Phe Leu Asn Gly
                3765                3770                3775    
Leu Glu Ile Leu Leu Ala Lys Ala Gln Asp Trp Glu Glu Asn Ala Ser
            3780                3785                3790        
Arg Ala Leu Ser Leu Arg Lys His Leu Asp Leu Ile Ser Gln Met Ile
        3795                3800                3805            
Ile Arg Trp Arg Lys Leu Glu Leu Asn Cys Trp Ser Met Ser Leu Asp
    3810                3815                3820                
Asn Thr Met Lys Arg His Thr Glu Lys Ser Thr Lys His Trp Phe Ser
3825                3830                3835                3840
Ile Tyr Gln Met Leu Glu Lys His Met Gln Glu Gln Thr Glu Glu Gln
                3845                3850                3855    
Glu Asp Asp Lys Gln Met Thr Leu Met Leu Leu Val Ser Thr Leu Gln
            3860                3865                3870        
Ala Phe Ile Glu Gly Ser Ser Leu Gly Glu Phe His Val Arg Leu Gln
        3875                3880                3885            
Met Leu Leu Val Phe His Cys His Val Leu Leu Met Pro Gln Val Glu
    3890                3895                3900                
Gly Lys Asp Ser Leu Cys Ser Val Leu Trp Asn Leu Tyr His Tyr Tyr
3905                3910                3915                3920
Lys Gln Phe Phe Asp Arg Val Gln Ala Lys Ile Val Glu Leu Arg Ser
                3925                3930                3935    
Pro Leu Glu Lys Glu Leu Lys Glu Phe Val Lys Ile Ser Lys Trp Asn
            3940                3945                3950        
Asp Val Ser Phe Trp Ser Ile Lys Gln Ser Val Glu Lys Thr His Arg
        3955                3960                3965            
Thr Leu Phe Lys Phe Met Lys Lys Phe Glu Ala Val Leu Ser Glu Pro
    3970                3975                3980                
Cys Arg Ser Ser Leu Val Glu Ser Asp Lys Glu Glu Gln Pro Asp Phe
3985                3990                3995                4000
Leu Pro Arg Pro Thr Asp Gly Ala Ala Ser Glu Leu Ser Ser Ile Gln
                4005                4010                4015    
Asn Leu Asn Arg Ala Leu Arg Glu Thr Leu Leu Ala Gln Pro Ala Ala
            4020                4025                4030        
Gly Gln Ala Thr Ile Pro Glu Trp Cys Gln Gly Ala Ala Pro Ser Gly
        4035                4040                4045            
Leu Glu Gly Glu Leu Leu Arg Arg Leu Pro Lys Leu Arg Lys Arg Met
    4050                4055                4060                
Arg Lys Met Cys Leu Thr Phe Met Lys Glu Ser Pro Leu Pro Arg Leu
4065                4070                4075                4080
Val Glu Gly Leu Asp Gln Phe Thr Gly Glu Val Ile Ser Ser Val Ser
                4085                4090                4095    
Glu Leu Gln Ser Leu Lys Val Glu Pro Ser Ala Glu Lys Glu Lys Gln
            4100                4105                4110        
Arg Ser Glu Ala Lys His Ile Leu Met Gln Lys Gln Arg Ala Leu Ser
        4115                4120                4125            
Asp Leu Phe Lys His Leu Ala Lys Ile Gly Leu Ser Tyr Arg Lys Gly
    4130                4135                4140                
Leu Ala Trp Ala Arg Ser Lys Asn Pro Gln Glu Met Leu His Leu His
4145                4150                4155                4160
Pro Leu Asp Leu Gln Ser Ala Leu Ser Ile Val Ser Ser Thr Gln Glu
                4165                4170                4175    
Ala Asp Ser Arg Leu Leu Thr Glu Ile Ser Ser Ser Trp Asp Gly Cys
            4180                4185                4190        
Gln Lys Tyr Phe Tyr Arg Ser Leu Ala Arg His Ala Arg Leu Asn Ala
        4195                4200                4205            
Ala Leu Ala Thr Pro Ala Lys Glu Met Gly Met Gly Asn Val Glu Arg
    4210                4215                4220                
Cys Arg Gly Phe Ser Ala His Leu Met Lys Met Leu Val Arg Gln Arg
4225                4230                4235                4240
Arg Ser Leu Thr Thr Leu Ser Glu Gln Trp Ile Ile Leu Arg Asn Leu
                4245                4250                4255    
Leu Ser Cys Val Gln Glu Ile His Ser Arg Leu Met Gly Pro Gln Ala
            4260                4265                4270        
Tyr Pro Val Ala Phe Pro Pro Gln Asp Gly Val Gln Gln Trp Thr Glu
        4275                4280                4285            
Arg Leu Gln His Leu Ala Met Gln Cys Gln Ile Leu Leu Glu Gln Leu
    4290                4295                4300                
Ser Trp Leu Leu Gln Cys Cys Pro Ser Val Gly Pro Ala Pro Gly His
4305                4310                4315                4320
Gly Asn Val Gln Val Leu Gly Gln Pro Pro Gly Pro Cys Leu Glu Gly
                4325                4330                4335    
Pro Glu Leu Ser Lys Gly Gln Leu Cys Gly Val Val Leu Asp Leu Ile
            4340                4345                4350        
Pro Ser Asn Leu Ser Tyr Pro Ser Pro Ile Pro Gly Ser Gln Leu Pro
        4355                4360                4365            
Ser Gly Cys Arg Met Arg Lys Gln Asp His Leu Trp Gln Gln Ser Thr
    4370                4375                4380                
Thr Arg Leu Thr Glu Met Leu Lys Thr Ile Lys Thr Val Lys Ala Asp
4385                4390                4395                4400
Val Asp Lys Ile Arg Gln Gln Ser Cys Glu Thr Leu Phe His Ser Trp
                4405                4410                4415    
Lys Asp Phe Glu Val Cys Ser Ser Ala Leu Ser Cys Leu Ser Gln Val
            4420                4425                4430        
Ser Val His Leu Gln Gly Leu Glu Ser Leu Phe Ile Leu Pro Gly Met
        4435                4440                4445            
Glu Val Glu Gln Arg Asp Ser Gln Met Ala Leu Val Glu Ser Leu Glu
    4450                4455                4460                
Tyr Val Arg Gly Glu Ile Ser Lys Ala Met Ala Asp Phe Thr Thr Trp
4465                4470                4475                4480
Lys Thr His Leu Leu Thr Ser Asp Ser Gln Gly Gly Asn Gln Met Leu
                4485                4490                4495    
Asp Glu Gly Phe Val Glu Asp Phe Ser Glu Gln Met Glu Ile Ala Ile
            4500                4505                4510        
Arg Ala Ile Leu Cys Ala Ile Gln Asn Leu Glu Glu Arg Lys Asn Glu
        4515                4520                4525            
Lys Ala Glu Glu Asn Thr Asp Gln Ala Ser Pro Gln Glu Asp Tyr Ala
    4530                4535                4540                
Gly Phe Glu Arg Leu Gln Ser Gly His Leu Thr Lys Leu Leu Glu Asp
4545                4550                4555                4560
Asp Phe Trp Ala Asp Val Ser Thr Leu His Val Gln Lys Ile Ile Ser
                4565                4570                4575    
Ala Ile Ser Glu Leu Leu Glu Arg Leu Lys Ser Tyr Gly Glu Asp Gly
            4580                4585                4590        
Thr Ala Ala Lys His Leu Phe Phe Ser Gln Ser Cys Ser Leu Leu Val
        4595                4600                4605            
Arg Leu Val Pro Val Leu Ser Ser Tyr Ser Asp Leu Val Leu Phe Phe
    4610                4615                4620                
Leu Thr Met Ser Leu Ala Thr His Arg Ser Thr Ala Lys Leu Leu Ser
4625                4630                4635                4640
Val Leu Ala Gln Val Phe Thr Glu Leu Ala Gln Lys Gly Phe Cys Leu
                4645                4650                4655    
Pro Lys Glu Phe Met Glu Asp Ser Ala Gly Glu Gly Ala Thr Glu Phe
            4660                4665                4670        
His Asp Tyr Glu Gly Gly Gly Ile Gly Glu Gly Glu Gly Met Lys Asp
        4675                4680                4685            
Val Ser Asp Gln Ile Gly Asn Glu Glu Gln Val Glu Asp Thr Phe Gln
    4690                4695                4700                
Lys Gly Gln Glu Lys Asp Lys Glu Asp Pro Asp Ser Lys Ser Asp Ile
4705                4710                4715                4720
Lys Gly Glu Asp Asn Ala Ile Glu Met Ser Glu Asp Phe Asp Gly Lys
                4725                4730                4735    
Met His Asp Gly Glu Leu Glu Glu Gln Glu Glu Asp Asp Glu Lys Ser
            4740                4745                4750        
Asp Ser Glu Gly Gly Asp Leu Asp Lys His Met Gly Asp Leu Asn Gly
        4755                4760                4765            
Glu Glu Ala Asp Lys Leu Asp Glu Arg Leu Trp Gly Asp Asp Asp Glu
    4770                4775                4780                
Glu Glu Asp Glu Glu Glu Glu Asp Asn Lys Thr Glu Glu Thr Gly Pro
4785                4790                4795                4800
Gly Met Asp Glu Glu Asp Ser Glu Leu Val Ala Lys Asp Asp Asn Leu
                4805                4810                4815    
Asp Ser Gly Asn Ser Asn Lys Asp Lys Ser Gln Gln Asp Lys Lys Glu
            4820                4825                4830        
Glu Lys Glu Glu Ala Glu Ala Asp Asp Gly Gly Gln Gly Glu Asp Lys
        4835                4840                4845            
Ile Asn Glu Gln Ile Asp Glu Arg Asp Tyr Asp Glu Asn Glu Val Asp
    4850                4855                4860                
Pro Tyr His Gly Asn Gln Glu Lys Val Pro Glu Pro Glu Ala Leu Asp
4865                4870                4875                4880
Leu Pro Asp Asp Leu Asn Leu Asp Ser Glu Asp Lys Asn Gly Gly Glu
                4885                4890                4895    
Asp Thr Asp Asn Glu Glu Gly Glu Glu Glu Asn Pro Leu Glu Ile Lys
            4900                4905                4910        
Glu Lys Pro Glu Glu Ala Gly His Glu Ala Glu Glu Arg Gly Glu Thr
        4915                4920                4925            
Glu Thr Asp Gln Asn Glu Ser Gln Ser Pro Gln Glu Pro Glu Glu Gly
    4930                4935                4940                
Pro Ser Glu Asp Asp Lys Ala Glu Gly Glu Glu Glu Met Asp Thr Gly
4945                4950                4955                4960
Ala Asp Asp Gln Asp Gly Asp Ala Ala Gln His Pro Glu Glu His Ser
                4965                4970                4975    
Glu Glu Gln Gln Gln Ser Val Glu Glu Lys Asp Lys Glu Ala Asp Glu
            4980                4985                4990        
Glu Gly Gly Glu Asn Gly Pro Ala Asp Gln Gly Phe Gln Pro Gln Glu
        4995                5000                5005            
Glu Glu Glu Arg Glu Asp Ser Asp Thr Glu Glu Gln Val Pro Glu Ala
    5010                5015                5020                
Leu Glu Arg Lys Glu His Ala Ser Cys Gly Gln Thr Gly Val Glu Asn
5025                5030                5035                5040
Met Gln Asn Thr Gln Ala Met Glu Leu Ala Gly Ala Ala Pro Glu Lys
                5045                5050                5055    
Glu Gln Gly Lys Glu Glu His Gly Ser Gly Ala Ala Asp Ala Asn Gln
            5060                5065                5070        
Ala Glu Gly His Glu Ser Asn Phe Ile Ala Gln Leu Ala Ser Gln Lys
        5075                5080                5085            
His Thr Arg Lys Asn Thr Gln Ser Phe Lys Arg Lys Pro Gly Gln Ala
    5090                5095                5100                
Asp Asn Glu Arg Ser Met Gly Asp His Asn Glu Arg Val His Lys Arg
5105                5110                5115                5120
Leu Arg Thr Val Asp Thr Asp Ser His Ala Glu Gln Gly Pro Ala Gln
                5125                5130                5135    
Gln Pro Gln Ala Gln Val Glu Asp Ala Asp Ala Phe Glu His Ile Lys
            5140                5145                5150        
Gln Gly Ser Asp Ala Tyr Asp Ala Gln Thr Tyr Asp Val Ala Ser Lys
        5155                5160                5165            
Glu Gln Gln Gln Ser Ala Lys Asp Ser Gly Lys Asp Gln Glu Glu Glu
    5170                5175                5180                
Glu Ile Glu Asp Thr Leu Met Asp Thr Glu Glu Gln Glu Glu Phe Lys
5185                5190                5195                5200
Ala Ala Asp Val Glu Gln Leu Lys Pro Glu Glu Ile Lys Ser Gly Thr
                5205                5210                5215    
Thr Ala Pro Leu Gly Phe Asp Glu Met Glu Val Glu Ile Gln Thr Val
            5220                5225                5230        
Lys Thr Glu Glu Asp Gln Asp Pro Arg Thr Asp Lys Ala His Lys Glu
        5235                5240                5245            
Thr Glu Asn Glu Lys Pro Glu Arg Ser Arg Glu Ser Thr Ile His Thr
    5250                5255                5260                
Ala His Gln Phe Leu Met Asp Thr Ile Phe Gln Pro Phe Leu Lys Asp
5265                5270                5275                5280
Val Asn Glu Leu Arg Gln Glu Leu Glu Arg Gln Leu Glu Met Trp Gln
                5285                5290                5295    
Pro Arg Glu Ser Gly Asn Pro Glu Glu Glu Lys Val Ala Ala Glu Met
            5300                5305                5310        
Trp Gln Ser Tyr Leu Ile Leu Thr Ala Pro Leu Ser Gln Arg Leu Cys
        5315                5320                5325            
Glu Glu Leu Arg Leu Ile Leu Glu Pro Thr Gln Ala Ala Lys Leu Lys
    5330                5335                5340                
Gly Asp Tyr Arg Thr Gly Lys Arg Leu Asn Ile Arg Lys Val Ile Pro
5345                5350                5355                5360
Tyr Ile Ala Ser Gln Phe Arg Lys Asp Lys Ile Trp Leu Arg Arg Thr
                5365                5370                5375    
Lys Pro Ser Lys Arg Gln Tyr Gln Ile Cys Leu Ala Ile Asp Asp Ser
            5380                5385                5390        
Ser Ser Met Val Asp Asn His Thr Lys Gln Leu Ala Phe Glu Ser Leu
        5395                5400                5405            
Ala Val Ile Gly Asn Ala Leu Thr Leu Leu Glu Val Gly Gln Ile Ala
    5410                5415                5420                
Val Cys Ser Phe Gly Glu Ser Val Lys Leu Leu His Pro Phe His Glu
5425                5430                5435                5440
Gln Phe Ser Asp Tyr Ser Gly Ser Gln Ile Leu Arg Leu Cys Lys Phe
                5445                5450                5455    
Gln Gln Lys Lys Thr Lys Ile Ala Gln Phe Leu Glu Ser Val Ala Asn
            5460                5465                5470        
Met Phe Ala Ala Ala Gln Gln Leu Ser Gln Asn Ile Ser Ser Glu Thr
        5475                5480                5485            
Ala Gln Leu Leu Leu Val Val Ser Asp Gly Arg Gly Leu Phe Leu Glu
    5490                5495                5500                
Gly Lys Glu Arg Val Leu Ala Ala Val Gln Ala Ala Arg Asn Ala Asn
5505                5510                5515                5520
Ile Phe Val Ile Phe Val Val Leu Asp Asn Pro Ser Ser Arg Asp Ser
                5525                5530                5535    
Ile Leu Asp Ile Lys Val Pro Ile Phe Lys Gly Pro Gly Glu Met Pro
            5540                5545                5550        
Glu Ile Arg Ser Tyr Met Glu Glu Phe Pro Phe Pro Tyr Tyr Ile Ile
        5555                5560                5565            
Leu Arg Asp Val Asn Ala Leu Pro Glu Thr Leu Ser Asp Ala Leu Arg
    5570                5575                5580                
Gln Trp Phe Glu Leu Val Thr Ala Ser Asp His Pro
5585                5590                5595    


<210> 8253
<211> 389
<212> PRT
<213> Homo sapiens

<400> 8253
Met Ala Pro Leu Asp Ile Val Leu Leu Pro Ala Lys Ala Lys Asp Asp
 1               5                  10                  15      
Arg Thr His Leu Gln Asn Leu Met Gln Phe Ser Gly Arg Lys Lys Asp
            20                  25                  30          
Gln Gln Glu Glu His Gly Ala Gly Gly Pro Ile Lys Phe Pro Ala Gly
        35                  40                  45              
Val Ser Pro Lys Gly Asp Ile Gly Gly Thr Gln Ser Thr Gln Ile Leu
    50                  55                  60                  
Ala Asn Gly Lys Pro Leu Ser Ser Asn His Lys Gln Arg Thr Pro Tyr
65                  70                  75                  80  
Cys Ser Ser Ser Glu Ser Gln Pro Leu Gln Pro Gln Lys Ile Lys Leu
                85                  90                  95      
Ala Gln Lys Ser Glu Ile Pro Lys Cys Ser Asn Ser Pro Gly Pro Leu
            100                 105                 110         
Gly Lys Ser Thr Val Cys Ser Ala Thr Ser Ser Gln Lys Ala Ser Leu
        115                 120                 125             
Leu Leu Glu Val Thr Gln Ser Asn Val Glu Ile Ile Thr Lys Glu Lys
    130                 135                 140                 
Val Met Val Ala Asn Ser Phe Arg Asn Lys Leu Trp Asn Trp Glu Lys
145                 150                 155                 160 
Val Ser Ser Gln Lys Ser Glu Met Ser Ser Ala Leu Leu Leu Ala Asn
                165                 170                 175     
Tyr Gly Ser Lys Ala Ile His Leu Glu Gly Gln Lys Gly Met Gly Leu
            180                 185                 190         
Thr Pro Glu Glu Pro Arg Lys Lys Leu Glu Thr Lys Gly Ala Gln Thr
        195                 200                 205             
Leu Pro Ser Gln Lys His Val Val Ala Pro Lys Ile Leu His Asn Val
    210                 215                 220                 
Ser Glu Asp Pro Ser Phe Val Ile Ser Gln His Ile Arg Lys Ser Trp
225                 230                 235                 240 
Glu Asn Pro Pro Pro Glu Arg Ser Pro Ala Ser Ser Pro Cys Gln Pro
                245                 250                 255     
Ile Tyr Glu Cys Glu Leu Ala Ser Gln Ala Pro Glu Lys Gln Pro Asp
            260                 265                 270         
Val Arg His His His Leu Pro Lys Thr Lys Pro Leu Pro Ser Ile Asp
        275                 280                 285             
Ser Leu Gly Pro Pro Pro Pro Lys Pro Ser Arg Pro Pro Ile Val Asn
    290                 295                 300                 
Leu Gln Ala Phe Gln Arg Gln Pro Ala Ala Val Pro Lys Thr Gln Gly
305                 310                 315                 320 
Glu Val Thr Val Glu Glu Gly Ser Leu Ser Pro Glu Arg Leu Phe Asn
                325                 330                 335     
Ala Glu Phe Glu Glu Pro His Asn Tyr Glu Ala Thr Ile Ser Tyr Leu
            340                 345                 350         
Arg His Ser Gly Asn Ser Ile Asn Leu Cys Thr Ala Lys Glu Ile Ala
        355                 360                 365             
Asp Arg Lys Ser Ala Lys Pro Ile Asn Ser Val Thr Leu Cys Gly Met
    370                 375                 380                 
Lys Met Cys Gln Lys
385                 


<210> 8254
<211> 288
<212> PRT
<213> Homo sapiens

<400> 8254
Met Lys Leu Pro Ile Phe Ile Ala Asp Ala Phe Thr Ala Arg Ala Phe
 1               5                  10                  15      
Arg Gly Asn Pro Ala Ala Val Cys Leu Leu Glu Asn Glu Leu Asp Glu
            20                  25                  30          
Asp Met His Gln Lys Ile Ala Arg Glu Met Asn Leu Ser Glu Thr Ala
        35                  40                  45              
Phe Ile Arg Lys Leu His Pro Thr Asp Asn Phe Ala Gln Ser Ser Cys
    50                  55                  60                  
Phe Gly Leu Arg Trp Phe Thr Pro Ala Ser Glu Val Pro Leu Cys Gly
65                  70                  75                  80  
His Ala Thr Leu Ala Ser Ala Ala Val Leu Phe His Lys Ile Lys Asn
                85                  90                  95      
Met Asn Ser Thr Leu Thr Phe Val Thr Leu Ser Gly Glu Leu Arg Ala
            100                 105                 110         
Arg Arg Ala Glu Asp Gly Ile Val Leu Asp Leu Pro Leu Tyr Pro Ala
        115                 120                 125             
His Pro Gln Asp Phe His Glu Val Glu Asp Leu Ile Lys Thr Ala Ile
    130                 135                 140                 
Gly Asn Thr Leu Val Gln Asp Ile Cys Tyr Ser Pro Asp Thr Gln Lys
145                 150                 155                 160 
Leu Leu Val Arg Leu Ser Asp Val Tyr Asn Arg Ser Phe Leu Glu Asn
                165                 170                 175     
Leu Lys Val Asn Thr Glu Asn Leu Leu Gln Val Glu Asn Thr Gly Lys
            180                 185                 190         
Val Lys Gly Leu Ile Leu Thr Leu Lys Gly Glu Pro Gly Gly Gln Thr
        195                 200                 205             
Gln Ala Phe Asp Phe Tyr Ser Arg Tyr Phe Ala Pro Trp Val Gly Val
    210                 215                 220                 
Ala Glu Asp Pro Val Thr Gly Ser Ala His Ala Val Leu Ser Ser Tyr
225                 230                 235                 240 
Trp Ser Gln His Leu Gly Lys Lys Glu Met His Ala Phe Gln Cys Ser
                245                 250                 255     
His Arg Gly Gly Glu Leu Gly Ile Ser Leu Arg Pro Asp Gly Arg Val
            260                 265                 270         
Asp Ile Arg Gly Gly Ala Ala Val Val Leu Glu Gly Thr Leu Thr Ala
        275                 280                 285             


<210> 8255
<211> 255
<212> PRT
<213> Homo sapiens

<400> 8255
Met His Gln Lys Ile Ala Arg Glu Met Asn Leu Ser Glu Thr Ala Phe
 1               5                  10                  15      
Ile Arg Lys Leu His Pro Thr Asp Asn Phe Ala Gln Ser Ser Cys Phe
            20                  25                  30          
Gly Leu Arg Trp Phe Thr Pro Ala Ser Glu Val Pro Leu Cys Gly His
        35                  40                  45              
Ala Thr Leu Ala Ser Ala Ala Val Leu Phe His Lys Ile Lys Asn Met
    50                  55                  60                  
Asn Ser Thr Leu Thr Phe Val Thr Leu Ser Gly Glu Leu Arg Ala Arg
65                  70                  75                  80  
Arg Ala Glu Asp Gly Ile Val Leu Asp Leu Pro Leu Tyr Pro Ala His
                85                  90                  95      
Pro Gln Asp Phe His Glu Val Glu Asp Leu Ile Lys Thr Ala Ile Gly
            100                 105                 110         
Asn Thr Leu Val Gln Asp Ile Cys Tyr Ser Pro Asp Thr Gln Lys Leu
        115                 120                 125             
Leu Val Arg Leu Ser Asp Val Tyr Asn Arg Ser Phe Leu Glu Asn Leu
    130                 135                 140                 
Lys Val Asn Thr Glu Asn Leu Leu Gln Val Glu Asn Thr Gly Lys Val
145                 150                 155                 160 
Lys Gly Leu Ile Leu Thr Leu Lys Gly Glu Pro Gly Gly Gln Thr Gln
                165                 170                 175     
Ala Phe Asp Phe Tyr Ser Arg Tyr Phe Ala Pro Trp Val Gly Val Ala
            180                 185                 190         
Glu Asp Pro Val Thr Gly Ser Ala His Ala Val Leu Ser Ser Tyr Trp
        195                 200                 205             
Ser Gln His Leu Gly Lys Lys Glu Met His Ala Phe Gln Cys Ser His
    210                 215                 220                 
Arg Gly Gly Glu Leu Gly Ile Ser Leu Arg Pro Asp Gly Arg Val Asp
225                 230                 235                 240 
Ile Arg Gly Gly Ala Ala Val Val Leu Glu Gly Thr Leu Thr Ala
                245                 250                 255 


<210> 8256
<211> 433
<212> PRT
<213> Homo sapiens

<400> 8256
Met Leu Glu Leu Ile Glu Val Asn Gly Thr Pro Gly Ser Gln Leu Ser
 1               5                  10                  15      
Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr Ser Pro Gly
            20                  25                  30          
Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser Ser Thr Ser
        35                  40                  45              
Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn Asp Gly Pro
    50                  55                  60                  
Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala Thr Ile Thr
65                  70                  75                  80  
Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn Phe Ala Val
                85                  90                  95      
Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr Ala Leu Lys
            100                 105                 110         
Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met Ile Gln Asn
        115                 120                 125             
Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile Val Leu Leu
    130                 135                 140                 
Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val Met Glu Leu
145                 150                 155                 160 
Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr Asn Lys Tyr
                165                 170                 175     
Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala Ser Ala Ile
            180                 185                 190         
Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile Lys Pro Glu
        195                 200                 205             
Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser Leu Lys Leu
    210                 215                 220                 
Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu Tyr Thr Val
225                 230                 235                 240 
Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala Glu Thr Gly
                245                 250                 255     
Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile Thr Tyr Ile
            260                 265                 270         
Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp Asp Gln Glu
        275                 280                 285             
Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe Pro Ser Pro
    290                 295                 300                 
Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile Thr Met Met
305                 310                 315                 320 
Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln Val Leu Glu
                325                 330                 335     
His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu His Gln Leu
            340                 345                 350         
Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly Pro Lys Pro
        355                 360                 365             
Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Thr Thr Ala Leu Asp
    370                 375                 380                 
Lys Glu Arg Gln Val Phe Arg Arg Arg Arg Asn Gln Asp Val Arg Ser
385                 390                 395                 400 
Arg Tyr Lys Ala Gln Pro Ala Pro Pro Glu Leu Asn Ser Glu Ser Glu
                405                 410                 415     
Asp Tyr Ser Pro Ser Ser Ser Glu Thr Val Arg Ser Pro Asn Ser Pro
            420                 425                 430         
Phe
    


<210> 8257
<211> 374
<212> PRT
<213> Homo sapiens

<400> 8257
Met Ala Lys Glu Arg Arg Arg Ala Val Leu Glu Leu Leu Gln Arg Pro
 1               5                  10                  15      
Gly Asn Ala Arg Cys Ala Asp Cys Gly Ala Pro Asp Pro Asp Trp Ala
            20                  25                  30          
Ser Tyr Thr Leu Gly Val Phe Ile Cys Leu Ser Cys Ser Gly Ile His
        35                  40                  45              
Arg Asn Ile Pro Gln Val Ser Lys Val Lys Ser Val Arg Leu Asp Ala
    50                  55                  60                  
Trp Glu Glu Ala Gln Val Glu Phe Met Ala Ser His Gly Asn Asp Ala
65                  70                  75                  80  
Ala Arg Ala Arg Phe Glu Ser Lys Val Pro Ser Phe Tyr Tyr Arg Pro
                85                  90                  95      
Thr Pro Ser Asp Cys Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys
            100                 105                 110         
Tyr Glu Arg Gln Glu Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser
        115                 120                 125             
Ala Gly Tyr Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly
    130                 135                 140                 
Gln Phe Leu Ser Arg Lys Phe Val Leu Thr Glu Arg Glu Gly Ala Leu
145                 150                 155                 160 
Lys Tyr Phe Asn Arg Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys
                165                 170                 175     
Ile Glu His Leu Asn Ala Thr Phe Gln Pro Ala Lys Ile Gly His Pro
            180                 185                 190         
His Gly Leu Gln Val Thr Tyr Leu Lys Asp Asn Ser Thr Arg Asn Ile
        195                 200                 205             
Phe Ile Tyr His Glu Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala
    210                 215                 220                 
Leu Arg Ala Ala Arg Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala
225                 230                 235                 240 
Ser Asp Ala Asp Leu Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu
                245                 250                 255     
Gly Tyr Met Glu Lys Thr Gly Pro Lys Gln Thr Glu Gly Phe Arg Lys
            260                 265                 270         
Arg Trp Phe Thr Met Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro
        275                 280                 285             
Leu Asp Ala Phe Ala Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser
    290                 295                 300                 
Gly Tyr Thr Val Leu His Gly Phe Pro Pro Ser Thr Gln Gly His His
305                 310                 315                 320 
Trp Pro His Gly Ile Thr Ile Val Thr Pro Asp Arg Lys Phe Leu Phe
                325                 330                 335     
Ala Cys Glu Thr Glu Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln
            340                 345                 350         
Lys Ala Val Asp Arg Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala
        355                 360                 365             
His Phe Lys His Lys Pro
    370                 


<210> 8258
<211> 1943
<212> PRT
<213> Homo sapiens

<400> 8258
Met Glu Glu Asn Glu Ser Gln Lys Cys Glu Pro Cys Leu Pro Tyr Ser
 1               5                  10                  15      
Ala Asp Arg Arg Gln Met Gln Glu Gln Gly Lys Gly Asn Leu His Val
            20                  25                  30          
Thr Ser Pro Glu Asp Ala Glu Cys Arg Arg Thr Lys Glu Arg Leu Ser
        35                  40                  45              
Asn Gly Asn Ser Arg Gly Ser Val Ser Lys Ser Ser Arg Asn Ile Pro
    50                  55                  60                  
Arg Arg His Thr Leu Gly Gly Pro Arg Ser Ser Lys Glu Ile Leu Gly
65                  70                  75                  80  
Met Gln Thr Ser Glu Met Asp Arg Lys Arg Glu Ala Phe Leu Glu His
                85                  90                  95      
Leu Lys Gln Lys Tyr Pro His His Ala Ser Ala Ile Met Gly His Gln
            100                 105                 110         
Glu Arg Leu Arg Asp Gln Thr Arg Ser Pro Lys Leu Ser His Ser Pro
        115                 120                 125             
Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr Ser
    130                 135                 140                 
Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro Phe
145                 150                 155                 160 
Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser Thr
                165                 170                 175     
Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr Gly
            180                 185                 190         
Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala Asp
        195                 200                 205             
Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met
    210                 215                 220                 
Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser
225                 230                 235                 240 
Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg
                245                 250                 255     
Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His
            260                 265                 270         
Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val
        275                 280                 285             
Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala
    290                 295                 300                 
His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro
305                 310                 315                 320 
His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg
                325                 330                 335     
Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser
            340                 345                 350         
Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu
        355                 360                 365             
Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile
    370                 375                 380                 
Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His
385                 390                 395                 400 
Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp
                405                 410                 415     
Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala
            420                 425                 430         
Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln
        435                 440                 445             
Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro
    450                 455                 460                 
Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp
465                 470                 475                 480 
Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro
                485                 490                 495     
His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys
            500                 505                 510         
Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala
        515                 520                 525             
Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln
    530                 535                 540                 
Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Arg
545                 550                 555                 560 
Glu Arg Met Gln Ala Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu
                565                 570                 575     
Val Gln Ser Ala Leu Phe Lys Gly Pro Ile Thr Ser Tyr Ser Lys Asp
            580                 585                 590         
Ala Ser Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr
        595                 600                 605             
Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala
    610                 615                 620                 
Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser
625                 630                 635                 640 
Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu
                645                 650                 655     
Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu
            660                 665                 670         
Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys
        675                 680                 685             
Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg
    690                 695                 700                 
Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys
705                 710                 715                 720 
Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys
                725                 730                 735     
Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu
            740                 745                 750         
Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu
        755                 760                 765             
Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg
    770                 775                 780                 
Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu
785                 790                 795                 800 
Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met
                805                 810                 815     
Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala
            820                 825                 830         
Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val
        835                 840                 845             
Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His
    850                 855                 860                 
Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser
865                 870                 875                 880 
Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro
                885                 890                 895     
Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His
            900                 905                 910         
Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln
        915                 920                 925             
Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala
    930                 935                 940                 
Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn
945                 950                 955                 960 
Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg
                965                 970                 975     
Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu
            980                 985                 990         
Glu Ala Gln Ala Asn Ile Met Lys Ser Ile Pro Asn Leu Glu Met Pro
        995                 1000                1005            
Pro Ala Thr Gly Pro Leu Pro Arg Gly Asp Ala Pro Val Asp Lys Val
    1010                1015                1020                
Glu Leu Ser Glu Asp Ser Pro Asn Ser Glu Gln Asp Leu Glu Lys Leu
1025                1030                1035                1040
Gly Gly Lys Ser Pro Pro Pro Pro Pro Pro Pro Pro Arg Arg Ser Tyr
                1045                1050                1055    
Leu Pro Gly Ser Gly Leu Thr Thr Thr Arg Ser Gly Asp Val Val Tyr
            1060                1065                1070        
Thr Gly Arg Lys Glu Asn Ile Thr Ala Lys Ala Ser Ser Glu Asp Ala
        1075                1080                1085            
Gly Pro Ser Pro Gln Thr Arg Ala Thr Lys Tyr Pro Ala Glu Glu Pro
    1090                1095                1100                
Ala Ser Ala Trp Thr Pro Ser Pro Pro Pro Val Thr Thr Ser Ser Ser
1105                1110                1115                1120
Lys Asp Glu Glu Glu Glu Glu Glu Glu Gly Asp Lys Ile Met Ala Glu
                1125                1130                1135    
Leu Gln Ala Phe Gln Lys Cys Ser Phe Met Asp Val Asn Ser Asn Ser
            1140                1145                1150        
His Ala Glu Pro Ser Arg Ala Asp Ser His Val Lys Asp Thr Arg Ser
        1155                1160                1165            
Gly Ala Thr Val Pro Pro Lys Glu Lys Lys Asn Leu Glu Phe Phe His
    1170                1175                1180                
Glu Asp Val Arg Lys Ser Asp Val Glu Tyr Glu Asn Gly Pro Gln Met
1185                1190                1195                1200
Glu Phe Gln Lys Val Thr Thr Gly Ala Val Arg Pro Ser Asp Pro Pro
                1205                1210                1215    
Lys Trp Glu Arg Gly Met Glu Asn Ser Ile Ser Asp Ala Ser Arg Thr
            1220                1225                1230        
Ser Glu Tyr Lys Thr Glu Ile Ile Met Lys Glu Asn Ser Ile Ser Asn
        1235                1240                1245            
Met Ser Leu Leu Arg Asp Ser Arg Asn Tyr Ser Gln Glu Thr Val Pro
    1250                1255                1260                
Lys Ala Ser Phe Gly Phe Ser Gly Ile Ser Pro Leu Glu Asp Glu Ile
1265                1270                1275                1280
Asn Lys Gly Ser Lys Ile Ser Gly Leu Gln Tyr Ser Ile Pro Asp Thr
                1285                1290                1295    
Glu Asn Gln Thr Leu Asn Tyr Gly Lys Thr Lys Glu Met Glu Lys Gln
            1300                1305                1310        
Asn Thr Asp Lys Cys His Val Ser Ser His Thr Arg Leu Thr Glu Ser
        1315                1320                1325            
Ser Val His Asp Phe Lys Thr Glu Asp Gln Glu Val Ile Thr Thr Asp
    1330                1335                1340                
Phe Gly Gln Val Val Leu Arg Pro Lys Glu Ala Arg His Ala Asn Val
1345                1350                1355                1360
Asn Pro Asn Glu Asp Gly Glu Ser Ser Ser Ser Ser Pro Thr Glu Glu
                1365                1370                1375    
Asn Ala Ala Thr Asp Asn Ile Ala Phe Met Ile Thr Glu Thr Thr Val
            1380                1385                1390        
Gln Val Leu Ser Ser Gly Glu Val His Asp Ile Val Ser Gln Lys Gly
        1395                1400                1405            
Glu Asp Ile Gln Thr Val Asn Ile Asp Ala Arg Lys Glu Met Thr Pro
    1410                1415                1420                
Arg Gln Glu Gly Thr Asp Asn Glu Asp Pro Val Val Cys Leu Asp Lys
1425                1430                1435                1440
Lys Pro Val Ile Ile Ile Phe Asp Glu Pro Met Asp Ile Arg Ser Ala
                1445                1450                1455    
Tyr Lys Arg Leu Ser Thr Ile Phe Glu Glu Cys Asp Glu Glu Leu Glu
            1460                1465                1470        
Arg Met Met Met Glu Glu Lys Ile Glu Glu Glu Glu Glu Glu Glu Asn
        1475                1480                1485            
Gly Asp Ser Val Val Gln Asn Asn Asn Thr Ser Gln Met Ser His Lys
    1490                1495                1500                
Lys Val Ala Pro Gly Asn Leu Arg Thr Gly Gln Gln Val Glu Thr Lys
1505                1510                1515                1520
Ser Gln Pro His Ser Leu Ala Thr Glu Thr Arg Asn Pro Gly Gly Gln
                1525                1530                1535    
Glu Met Asn Arg Thr Glu Leu Asn Lys Phe Ser His Val Asp Ser Pro
            1540                1545                1550        
Asn Ser Glu Cys Lys Gly Glu Asp Ala Thr Asp Asp Gln Phe Glu Ser
        1555                1560                1565            
Pro Lys Lys Lys Phe Lys Phe Lys Phe Pro Lys Lys Gln Leu Ala Ala
    1570                1575                1580                
Leu Thr Gln Ala Ile Arg Thr Gly Thr Lys Thr Gly Lys Lys Thr Leu
1585                1590                1595                1600
Gln Val Val Val Tyr Glu Glu Glu Glu Glu Asp Gly Thr Leu Lys Gln
                1605                1610                1615    
His Lys Glu Ala Lys Arg Phe Glu Ile Ala Arg Ser Gln Pro Glu Asp
            1620                1625                1630        
Thr Pro Glu Asn Thr Val Arg Arg Gln Glu Gln Pro Ser Ile Glu Ser
        1635                1640                1645            
Thr Ser Pro Ile Ser Arg Thr Asp Glu Ile Arg Lys Asn Thr Tyr Arg
    1650                1655                1660                
Thr Leu Asp Ser Leu Glu Gln Thr Ile Lys Gln Leu Glu Asn Thr Ile
1665                1670                1675                1680
Ser Glu Met Ser Pro Lys Ala Leu Val Asp Thr Ser Cys Ser Ser Asn
                1685                1690                1695    
Arg Asp Ser Val Ala Ser Ser Ser His Ile Ala Gln Glu Ala Ser Pro
            1700                1705                1710        
Arg Pro Leu Leu Val Pro Asp Glu Gly Pro Thr Ala Leu Glu Pro Pro
        1715                1720                1725            
Thr Ser Ile Pro Ser Ala Ser Arg Lys Gly Ser Ser Gly Ala Pro Gln
    1730                1735                1740                
Thr Ser Arg Met Pro Val Pro Met Ser Ala Lys Asn Arg Pro Gly Thr
1745                1750                1755                1760
Leu Asp Lys Pro Gly Lys Gln Ser Lys Leu Gln Asp Pro Arg Gln Tyr
                1765                1770                1775    
Arg Gln Ala Asn Gly Ser Ala Lys Lys Ser Gly Gly Asp Phe Lys Pro
            1780                1785                1790        
Thr Ser Pro Ser Leu Pro Ala Ser Lys Ile Pro Ala Leu Ser Pro Ser
        1795                1800                1805            
Ser Gly Lys Ser Ser Ser Leu Pro Ser Ser Ser Gly Asp Ser Ser Asn
    1810                1815                1820                
Leu Pro Asn Pro Pro Ala Thr Lys Pro Ser Ile Ala Ser Asn Pro Leu
1825                1830                1835                1840
Ser Pro Gln Thr Gly Pro Pro Ala His Ser Ala Ser Leu Ile Pro Ser
                1845                1850                1855    
Val Ser Asn Gly Ser Leu Lys Phe Gln Ser Leu Thr His Thr Gly Lys
            1860                1865                1870        
Gly His His Leu Ser Phe Ser Pro Gln Ser Gln Asn Gly Arg Ala Pro
        1875                1880                1885            
Pro Pro Leu Ser Phe Ser Ser Ser Pro Pro Ser Pro Ala Ser Ser Val
    1890                1895                1900                
Ser Leu Asn Gln Gly Ala Lys Gly Thr Arg Thr Ile His Thr Pro Ser
1905                1910                1915                1920
Leu Thr Ser Tyr Lys Ala Gln Asn Gly Ser Ser Ser Lys Ala Thr Pro
                1925                1930                1935    
Ser Thr Ala Lys Glu Thr Ser
            1940            


<210> 8259
<211> 268
<212> PRT
<213> Homo sapiens

<400> 8259
Ala Ala Ala Ala Val Glu Glu Val Ser Ser Ala Gly Gln Phe Glu Glu
 1               5                  10                  15      
Leu Leu Arg Leu Lys Ala Lys Ser Leu Leu Val Pro Gln Cys Ala Gln
            20                  25                  30          
Met Asn Glu Val Met Ala Glu Leu Ala Lys Glu His Pro Gln Val Ser
        35                  40                  45              
Phe Val Lys Leu Glu Ala Glu Gly Val Pro Glu Val Ser Glu Lys Tyr
    50                  55                  60                  
Glu Ile Gly Ser Val Pro Thr Phe Leu Phe Phe Asn Asn Ser Gln Lys
65                  70                  75                  80  
Ile Asp Arg Leu Asp Gly Thr Pro Gln Glu Pro Leu Cys Gly Phe Ser
                85                  90                  95      
Lys Gln Met Val Glu Ile Val His Lys His Asn Ile Ser Leu Ala Val
            100                 105                 110         
Leu Met Ser Leu Asp Gln Glu Val Arg Gln Gly Leu Lys Ala Tyr Ser
        115                 120                 125             
Asn Trp Pro Thr Tyr Pro Gln Leu Tyr Val Ser Gly Glu Leu Ile Gly
    130                 135                 140                 
Gly Leu Asp Ile Ile Lys Glu Ile His Ala Ser Glu Glu Leu Asp Ile
145                 150                 155                 160 
Ile Cys Pro Lys Ala Pro Lys Leu Glu Glu Arg Leu Lys Val Leu Thr
                165                 170                 175     
Asn Glu Ala Ser Met Met Leu Phe Met Lys Gly Asn Lys Gln Glu Ala
            180                 185                 190         
Lys Cys Gly Phe Ser Lys Gln Ile Leu Glu Ile Leu Asn Ser Thr Gly
        195                 200                 205             
Gly Glu Tyr Glu Thr Phe Asp Ile Leu Glu Asp Glu Gly Asp Arg Gln
    210                 215                 220                 
Gly Leu Lys Ala Tyr Ser Asn Trp Pro Thr Tyr Pro Gln Leu Tyr Val
225                 230                 235                 240 
Lys Gly Glu Leu Val Gly Gly Leu Asp Ile Val Lys Glu Leu Lys Glu
                245                 250                 255     
Asn Gly Glu Leu Leu Pro Ile Leu Arg Gly Glu Asn
            260                 265             


<210> 8260
<211> 1956
<212> PRT
<213> Homo sapiens

<400> 8260
Gly Asp Arg Arg Arg Ala Ala Ser Gly Gly Gly Pro Gly Pro Ala Val
 1               5                  10                  15      
Ser Glu Met Ser Arg Trp Leu Trp Pro Trp Ser Asn Cys Val Lys Glu
            20                  25                  30          
Arg Val Cys Arg Tyr Leu Leu His His Tyr Leu Gly His Phe Phe Gln
        35                  40                  45              
Glu His Leu Ser Leu Asp Gln Leu Ser Leu Asp Leu Tyr Lys Gly Ser
    50                  55                  60                  
Val Ala Leu Arg Asp Ile His Leu Glu Ile Trp Ser Val Asn Glu Val
65                  70                  75                  80  
Leu Glu Ser Met Glu Ser Pro Leu Glu Leu Val Glu Gly Phe Val Gly
                85                  90                  95      
Ser Ile Glu Val Ala Val Pro Trp Ala Ala Leu Leu Thr Asp His Cys
            100                 105                 110         
Thr Val Arg Val Ser Gly Leu Gln Leu Thr Leu Gln Pro Arg Arg Gly
        115                 120                 125             
Pro Ala Pro Gly Ala Ala Asp Ser Gln Ser Trp Ala Ser Cys Met Thr
    130                 135                 140                 
Thr Ser Leu Gln Leu Ala Gln Glu Cys Leu Arg Asp Gly Leu Pro Glu
145                 150                 155                 160 
Pro Ser Glu Pro Pro Gln Pro Leu Glu Gly Leu Glu Met Phe Ala Gln
                165                 170                 175     
Thr Ile Glu Thr Val Leu Arg Arg Ile Lys Val Thr Phe Leu Asp Thr
            180                 185                 190         
Val Val Arg Val Glu His Ser Pro Gly Asp Gly Glu Arg Gly Val Ala
        195                 200                 205             
Val Glu Val Arg Val Gln Arg Leu Glu Tyr Cys Asp Glu Ala Val Arg
    210                 215                 220                 
Asp Pro Ser Gln Ala Pro Pro Val Asp Val His Gln Pro Pro Ala Phe
225                 230                 235                 240 
Leu His Lys Leu Leu Gln Leu Ala Gly Val Arg Leu His Tyr Glu Glu
                245                 250                 255     
Leu Pro Ala Gln Glu Glu Pro Pro Glu Pro Pro Leu Gln Ile Gly Ser
            260                 265                 270         
Cys Ser Gly Tyr Met Glu Leu Met Val Lys Leu Lys Gln Asn Glu Ala
        275                 280                 285             
Phe Pro Gly Pro Lys Leu Glu Val Ala Gly Gln Leu Gly Ser Leu His
    290                 295                 300                 
Leu Leu Leu Thr Pro Arg Gln Leu Gln Gln Leu Gln Glu Leu Leu Ser
305                 310                 315                 320 
Ala Val Ser Leu Thr Asp His Glu Gly Leu Ala Asp Lys Leu Asn Lys
                325                 330                 335     
Ser Arg Pro Leu Gly Ala Glu Asp Leu Trp Leu Ile Glu Gln Asp Leu
            340                 345                 350         
Asn Gln Gln Leu Gln Ala Gly Ala Val Ala Glu Pro Leu Ser Pro Asp
        355                 360                 365             
Pro Leu Thr Asn Pro Leu Leu Asn Leu Asp Asn Thr Asp Leu Phe Phe
    370                 375                 380                 
Ser Met Ala Gly Leu Thr Ser Ser Val Ala Ser Ala Leu Ser Glu Leu
385                 390                 395                 400 
Ser Leu Ser Asp Val Asp Leu Ala Ser Ser Val Arg Ser Asp Met Ala
                405                 410                 415     
Ser Arg Arg Leu Ser Ala Gln Ala His Pro Ala Gly Lys Met Ala Pro
            420                 425                 430         
Asn Pro Leu Leu Asp Thr Met Arg Pro Asp Ser Leu Leu Lys Met Thr
        435                 440                 445             
Leu Gly Gly Val Thr Leu Thr Leu Leu Gln Thr Ser Ala Pro Ser Ser
    450                 455                 460                 
Gly Pro Pro Asp Leu Ala Thr His Phe Phe Thr Glu Phe Asp Ala Thr
465                 470                 475                 480 
Lys Asp Gly Pro Phe Gly Ser Arg Asp Phe His His Leu Arg Pro Arg
                485                 490                 495     
Phe Gln Arg Ala Cys Pro Cys Ser His Val Arg Leu Thr Gly Thr Ala
            500                 505                 510         
Val Gln Leu Ser Trp Glu Leu Arg Thr Gly Ser Arg Gly Arg Arg Thr
        515                 520                 525             
Thr Ser Met Glu Val His Phe Gly Gln Leu Glu Val Leu Glu Cys Leu
    530                 535                 540                 
Trp Pro Arg Gly Thr Ser Glu Pro Glu Tyr Thr Glu Ile Leu Thr Phe
545                 550                 555                 560 
Pro Gly Thr Leu Gly Ser Gln Ala Ser Ala Arg Pro Cys Ala His Leu
                565                 570                 575     
Arg His Thr Gln Ile Leu Arg Arg Val Pro Lys Ser Arg Pro Arg Arg
            580                 585                 590         
Ser Val Ala Cys His Cys His Ser Glu Leu Ala Leu Asp Leu Ala Asn
        595                 600                 605             
Phe Gln Ala Asp Val Glu Leu Gly Ala Leu Asp Arg Leu Ala Ala Leu
    610                 615                 620                 
Leu Arg Leu Ala Thr Val Pro Ala Glu Pro Pro Ala Gly Leu Leu Thr
625                 630                 635                 640 
Glu Pro Leu Pro Ala Met Glu Gln Gln Thr Val Phe Arg Leu Ser Ala
                645                 650                 655     
Pro Arg Ala Thr Leu Arg Leu Arg Phe Pro Ile Ala Asp Leu Arg Pro
            660                 665                 670         
Glu Arg Asp Pro Trp Ala Gly Gln Ala Val Arg Ala Glu Gln Leu Arg
        675                 680                 685             
Leu Glu Leu Ser Glu Pro Gln Phe Arg Ser Glu Leu Ser Ser Gly Pro
    690                 695                 700                 
Gly Pro Pro Val Pro Thr His Leu Glu Leu Thr Cys Ser Asp Leu His
705                 710                 715                 720 
Gly Ile Tyr Glu Asp Gly Gly Lys Pro Pro Val Pro Cys Leu Arg Val
                725                 730                 735     
Ser Lys Ala Leu Asp Pro Lys Ser Thr Gly Arg Lys Tyr Phe Leu Pro
            740                 745                 750         
Gln Val Val Val Thr Val Asn Pro Gln Ser Ser Ser Thr Gln Trp Glu
        755                 760                 765             
Val Ala Pro Glu Lys Gly Glu Glu Leu Glu Leu Ser Val Glu Ser Pro
    770                 775                 780                 
Cys Glu Leu Arg Glu Pro Glu Pro Ser Pro Phe Ser Ser Lys Arg Thr
785                 790                 795                 800 
Met Tyr Glu Thr Glu Glu Met Val Ile Pro Gly Asp Pro Glu Glu Met
                805                 810                 815     
Arg Thr Phe Gln Ser Arg Thr Leu Ala Leu Ser Arg Cys Ser Leu Glu
            820                 825                 830         
Val Ile Leu Pro Ser Val His Ile Phe Leu Pro Ser Lys Glu Val Tyr
        835                 840                 845             
Glu Ser Ile Tyr Asn Arg Ile Asn Asn Asp Leu Leu Met Trp Glu Pro
    850                 855                 860                 
Ala Asp Leu Leu Pro Thr Pro Asp Pro Ala Ala Gln Pro Ser Gly Phe
865                 870                 875                 880 
Pro Gly Pro Ser Gly Phe Trp His Asp Ser Phe Lys Met Cys Lys Ser
                885                 890                 895     
Ala Phe Lys Leu Ala Asn Cys Phe Asp Leu Thr Pro Asp Ser Asp Ser
            900                 905                 910         
Asp Asp Glu Asp Ala His Phe Phe Ser Val Gly Ala Ser Gly Gly Pro
        915                 920                 925             
Gln Ala Ala Ala Pro Glu Ala Pro Ser Leu His Leu Gln Ser Thr Phe
    930                 935                 940                 
Ser Thr Leu Val Thr Val Leu Lys Gly Arg Ile Thr Ala Leu Cys Glu
945                 950                 955                 960 
Thr Lys Asp Glu Gly Gly Lys Arg Leu Glu Ala Val His Gly Glu Leu
                965                 970                 975     
Val Leu Asp Met Glu His Gly Thr Leu Phe Ser Val Ser Gln Tyr Cys
            980                 985                 990         
Gly Gln Pro Gly Leu Gly Tyr Phe Cys Leu Glu Ala Glu Lys Ala Thr
        995                 1000                1005            
Leu Tyr His Arg Ala Ala Val Asp Asp Tyr Pro Leu Pro Ser His Leu
    1010                1015                1020                
Asp Leu Pro Ser Phe Ala Pro Pro Ala Gln Leu Ala Pro Thr Ile Tyr
1025                1030                1035                1040
Pro Ser Glu Glu Gly Val Thr Glu Arg Gly Ala Ser Gly Arg Lys Gly
                1045                1050                1055    
Gln Gly Arg Gly Pro His Met Leu Ser Thr Ala Val Arg Ile His Leu
            1060                1065                1070        
Asp Pro His Lys Asn Val Lys Glu Phe Leu Val Thr Leu Arg Leu His
        1075                1080                1085            
Lys Ala Thr Leu Arg His Tyr Met Ala Leu Pro Glu Gln Ser Trp His
    1090                1095                1100                
Ser Gln Leu Leu Glu Phe Leu Asp Val Leu Asp Asp Pro Val Leu Gly
1105                1110                1115                1120
Tyr Leu Pro Pro Thr Val Ile Thr Ile Leu His Thr His Leu Phe Ser
                1125                1130                1135    
Cys Ser Val Asp Tyr Arg Pro Leu Tyr Leu Pro Val Arg Val Leu Ile
            1140                1145                1150        
Thr Ala Glu Thr Phe Thr Leu Ser Ser Asn Ile Ile Met Asp Thr Ser
        1155                1160                1165            
Thr Phe Leu Leu Arg Phe Ile Leu Asp Asp Ser Ala Leu Tyr Leu Ser
    1170                1175                1180                
Asp Lys Cys Glu Val Glu Thr Leu Asp Leu Arg Arg Asp Tyr Val Cys
1185                1190                1195                1200
Val Leu Asp Val Asp Leu Leu Glu Leu Val Ile Lys Thr Trp Lys Gly
                1205                1210                1215    
Ser Thr Glu Gly Lys Leu Ser Gln Pro Leu Phe Glu Leu Arg Cys Ser
            1220                1225                1230        
Asn Asn Val Val His Val His Ser Cys Ala Asp Ser Cys Ala Leu Leu
        1235                1240                1245            
Val Asn Leu Leu Gln Tyr Val Met Ser Thr Gly Asp Leu His Pro Pro
    1250                1255                1260                
Pro Arg Pro Pro Ser Pro Thr Glu Ile Ala Gly Gln Lys Leu Ser Glu
1265                1270                1275                1280
Ser Pro Ala Ser Leu Pro Ser Cys Pro Pro Val Glu Thr Ala Leu Ile
                1285                1290                1295    
Asn Gln Arg Asp Leu Ala Asp Ala Leu Leu Asp Thr Glu Arg Ser Leu
            1300                1305                1310        
Arg Glu Leu Ala Gln Pro Ser Gly Gly His Leu Pro Gln Ala Ser Pro
        1315                1320                1325            
Ile Ser Val Tyr Leu Phe Pro Gly Glu Arg Ser Gly Ala Pro Pro Pro
    1330                1335                1340                
Ser Pro Pro Val Gly Gly Pro Ala Gly Ser Leu Gly Ser Cys Ser Glu
1345                1350                1355                1360
Glu Lys Glu Asp Glu Arg Glu Glu Glu Gly Asp Gly Asp Thr Leu Asp
                1365                1370                1375    
Ser Asp Glu Phe Cys Ile Leu Asp Ala Pro Gly Leu Gly Ile Pro Pro
            1380                1385                1390        
Arg Asp Gly Glu Pro Val Val Thr Gln Leu His Pro Gly Pro Ile Val
        1395                1400                1405            
Val Arg Asp Gly Tyr Phe Ser Arg Pro Ile Gly Ser Thr Asp Leu Leu
    1410                1415                1420                
Arg Ala Pro Ala His Phe Pro Val Pro Ser Thr Arg Val Val Leu Arg
1425                1430                1435                1440
Glu Val Ser Leu Val Trp His Leu Tyr Gly Gly Arg Asp Phe Gly Pro
                1445                1450                1455    
His Pro Gly His Arg Ala Arg Thr Gly Leu Ser Gly Pro Arg Ser Ser
            1460                1465                1470        
Pro Ser Arg Cys Ser Gly Pro Asn Arg Pro Gln Asn Ser Trp Arg Thr
        1475                1480                1485            
Gln Gly Gly Ser Gly Arg Gln His His Val Leu Met Glu Ile Gln Leu
    1490                1495                1500                
Ser Lys Val Ser Phe Gln His Glu Val Tyr Pro Ala Glu Pro Ala Thr
1505                1510                1515                1520
Gly Pro Ala Ala Pro Ser Gln Glu Leu Glu Glu Arg Pro Leu Ser Arg
                1525                1530                1535    
Gln Val Phe Ile Val Gln Glu Leu Glu Val Arg Asp Arg Leu Ala Ser
            1540                1545                1550        
Ser Gln Ile Asn Lys Phe Leu Tyr Leu His Thr Ser Glu Arg Met Pro
        1555                1560                1565            
Arg Arg Ala His Ser Asn Met Leu Thr Ile Lys Ala Leu His Val Ala
    1570                1575                1580                
Pro Thr Thr Asn Leu Gly Gly Pro Glu Cys Cys Leu Arg Val Ser Leu
1585                1590                1595                1600
Met Pro Leu Arg Leu Asn Val Asp Gln Asp Ala Leu Phe Phe Leu Lys
                1605                1610                1615    
Asp Phe Phe Thr Ser Leu Val Ala Gly Ile Asn Pro Val Val Pro Gly
            1620                1625                1630        
Glu Thr Ser Ala Glu Ala Arg Pro Glu Thr Arg Ala Gln Pro Ser Ser
        1635                1640                1645            
Pro Leu Glu Gly Gln Ala Glu Gly Val Glu Thr Thr Gly Ser Gln Glu
    1650                1655                1660                
Ala Pro Gly Gly Gly His Ser Pro Ser Pro Pro Asp Gln Gln Pro Ile
1665                1670                1675                1680
Tyr Phe Arg Glu Phe Arg Phe Thr Ser Glu Val Pro Ile Trp Leu Asp
                1685                1690                1695    
Tyr His Gly Lys His Val Thr Met Asp Gln Val Gly Thr Phe Ala Gly
            1700                1705                1710        
Leu Leu Ile Gly Leu Ala Gln Leu Asn Cys Ser Glu Leu Lys Leu Lys
        1715                1720                1725            
Arg Leu Cys Cys Arg His Gly Leu Leu Gly Val Asp Lys Val Leu Gly
    1730                1735                1740                
Tyr Ala Leu Asn Glu Trp Leu Gln Asp Ile Arg Lys Asn Gln Leu Pro
1745                1750                1755                1760
Gly Leu Leu Gly Gly Val Gly Pro Met His Ser Val Val Gln Leu Phe
                1765                1770                1775    
Gln Gly Phe Arg Asp Leu Leu Trp Leu Pro Ile Glu Gln Tyr Arg Lys
            1780                1785                1790        
Asp Gly Arg Leu Met Arg Gly Leu Gln Arg Gly Ala Ala Ser Phe Gly
        1795                1800                1805            
Ser Ser Thr Ala Ser Ala Ala Leu Glu Leu Ser Asn Arg Leu Val Gln
    1810                1815                1820                
Ala Ile Gln Ala Thr Ala Glu Thr Val Tyr Asp Ile Leu Ser Pro Ala
1825                1830                1835                1840
Ala Pro Val Ser Arg Ser Leu Gln Asp Lys Arg Ser Ala Arg Arg Leu
                1845                1850                1855    
Arg Arg Gly Gln Gln Pro Ala Asp Leu Arg Glu Gly Val Ala Lys Ala
            1860                1865                1870        
Tyr Asp Thr Val Arg Glu Gly Ile Leu Asp Thr Ala Gln Thr Ile Cys
        1875                1880                1885            
Asp Val Ala Ser Arg Gly His Glu Gln Lys Gly Leu Thr Gly Ala Val
    1890                1895                1900                
Gly Gly Val Ile Arg Gln Leu Pro Pro Thr Val Val Lys Pro Leu Ile
1905                1910                1915                1920
Leu Ala Thr Glu Ala Thr Ser Ser Leu Leu Gly Gly Met Arg Asn Gln
                1925                1930                1935    
Ile Val Pro Asp Ala His Lys Asp His Ala Leu Lys Trp Arg Ser Asp
            1940                1945                1950        
Ser Ala Gln Asp
        1955    


<210> 8261
<211> 133
<212> PRT
<213> Homo sapiens

<400> 8261
Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg
 1               5                  10                  15      
Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser
            20                  25                  30          
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys
        35                  40                  45              
Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp
    50                  55                  60                  
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro
65                  70                  75                  80  
Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys
                85                  90                  95      
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu
            100                 105                 110         
Val Asn Gly Ser Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu
        115                 120                 125             
Glu Val Leu Ser Leu
    130             


<210> 8262
<211> 160
<212> PRT
<213> Homo sapiens

<400> 8262
Met Val Asn Pro Thr Val Phe Phe Asp Thr Glu Pro Leu Gly Arg Ile
 1               5                  10                  15      
Ser Phe Glu Leu Phe Ala Asp Lys Phe Pro Lys Thr Ala Gly Asn Phe
            20                  25                  30          
His Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Cys
        35                  40                  45              
Phe His Arg Ile Val Pro Gly Phe Met Cys Gln Gly Gly Asp Phe Thr
    50                  55                  60                  
Cys His Asp Gly Thr Gly Gly Lys Ser Ile Tyr Arg Glu Lys Phe Asp
65                  70                  75                  80  
Asp Lys Asn Phe Ile Arg Lys His Thr Val Ser Gly Ile Leu Ser Met
                85                  90                  95      
Ala Asn Ala Gly Pro Asn Ala Asn Ser Ser Gln Phe Phe Ile Cys Ala
            100                 105                 110         
Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe Ser Lys Val
        115                 120                 125             
Lys Glu Gly Met Asn Ile Val Glu Thr Met Glu Cys Phe Gly Ser Arg
    130                 135                 140                 
Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys Gly Gln Leu
145                 150                 155                 160 


<210> 8263
<211> 945
<212> PRT
<213> Homo sapiens

<400> 8263
Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala
 1               5                  10                  15      
Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln
            20                  25                  30          
Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln
        35                  40                  45              
Gln His Pro Pro Pro Pro Pro Arg Arg Thr Arg Pro Glu Asp Gly Gly
    50                  55                  60                  
Pro Gly Ala Ala Ser Thr Ser Ala Ala Ala Met Ala Thr Val Gly Glu
65                  70                  75                  80  
Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn
                85                  90                  95      
Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Thr Glu Leu
            100                 105                 110         
Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu
        115                 120                 125             
Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp
    130                 135                 140                 
Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln
145                 150                 155                 160 
Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro
                165                 170                 175     
Pro Leu Ala Val Pro Pro Thr Ser Val Phe Ser Phe Phe Pro Ser Leu
            180                 185                 190         
Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser
        195                 200                 205             
Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser
    210                 215                 220                 
Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Thr Arg Pro Met His Pro
225                 230                 235                 240 
Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Thr Pro Ser Val
                245                 250                 255     
Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Thr Leu Leu Lys Ser
            260                 265                 270         
Ala Val Gly Pro Thr Cys Pro Ala Thr Val Ser Ser Leu Val Lys Pro
        275                 280                 285             
Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Thr Leu Pro Ser Pro Gly
    290                 295                 300                 
Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Thr Leu Glu Lys
305                 310                 315                 320 
Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu
                325                 330                 335     
Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu
            340                 345                 350         
Asp Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys Thr His Ser
        355                 360                 365             
Leu Thr Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val
    370                 375                 380                 
Leu Leu Ala Glu His Lys Asn Lys Thr Arg Glu Lys Glu Leu Ile Arg
385                 390                 395                 400 
His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro
                405                 410                 415     
Ala Pro Pro Arg Thr Ser Gln Glu Pro His Gln Asn Pro His Gly Val
            420                 425                 430         
Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His
        435                 440                 445             
Thr Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly
    450                 455                 460                 
Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro
465                 470                 475                 480 
Leu Pro Ala Thr Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu
                485                 490                 495     
Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser
            500                 505                 510         
Gly His His Pro Gln Pro Ala Ser Phe Cys Thr Phe Gly Ser Arg Gln
        515                 520                 525             
Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg
    530                 535                 540                 
Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp
545                 550                 555                 560 
Lys Lys Ile Pro Pro Val Pro Ser Thr Thr Ser Pro Ile Ser Thr Arg
                565                 570                 575     
Ile Pro His Arg Thr Asn Ser Val Pro Thr Ser Gln Cys Gly Val Ser
            580                 585                 590         
Tyr Leu Ala Ala Ala Thr Val Ser Thr Ser Pro Val Leu Leu Ser Ser
        595                 600                 605             
Thr Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Thr Thr
    610                 615                 620                 
Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser
625                 630                 635                 640 
Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Thr Pro
                645                 650                 655     
Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln
            660                 665                 670         
Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn
        675                 680                 685             
Ser Thr Asn Cys Gln Asn Ala Ser Ser Ser Thr Ser Gly Gly Ser Gly
    690                 695                 700                 
Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser
705                 710                 715                 720 
Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys
                725                 730                 735     
Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Thr Val Thr Ser
            740                 745                 750         
Ser His Ser Ile Gly Leu Asn Cys Val Thr Asn Lys Ala Asn Ala Val
        755                 760                 765             
Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Thr Gly Ser Pro
    770                 775                 780                 
Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser
785                 790                 795                 800 
Thr Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val
                805                 810                 815     
Asn Ser His Gly Ser Phe Ser His Ser His Thr Pro Leu Asp Lys Leu
            820                 825                 830         
Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn
        835                 840                 845             
Ser Ser Ser Lys Pro Thr Lys Val Ala Lys Val Pro Ala Val Asn Asn
    850                 855                 860                 
Val His Met Lys His Thr Gly Thr Ile Pro Gly Ala Gln Gly Leu Met
865                 870                 875                 880 
Asn Ser Ser Leu Leu His Gln Asp Ile Ser Ser Pro Cys Leu Arg Thr
                885                 890                 895     
Gly Ile Ser Ala Thr Ser Pro Gln Ser Pro Asp Leu Lys Ser Lys Gly
            900                 905                 910         
Thr Ser Leu Thr Ala Glu Asn Ser Thr Gly Arg Asn Asn Ala Asp Thr
        915                 920                 925             
Phe Glu Asp Lys Leu His Leu His Ser Ala Leu Trp Thr Pro Arg Cys
    930                 935                 940                 
Leu
945 


<210> 8264
<211> 466
<212> PRT
<213> Homo sapiens

<400> 8264
Met Glu Arg Thr Lys Ala Lys Thr Val Ser Phe Pro Gly Ser Pro Lys
 1               5                  10                  15      
Ala Leu Ala Ser Ala Gln Thr Arg Leu Arg Pro Trp Glu Ser Val Val
            20                  25                  30          
Gly Thr Glu Asn Asp Val Ala Leu Pro Leu Ala Ala Asn Val Ser His
        35                  40                  45              
Arg Ala Arg His Leu Cys Gly Arg Arg Leu Ala Cys Arg Met Leu Ser
    50                  55                  60                  
Cys Gln Gly His Ala Ala Cys Pro Pro Leu Pro Gly Arg Gly Asp Leu
65                  70                  75                  80  
Leu Ser Asn Ser Pro Val Ala Met Glu Glu Gly Leu Ser Gly Gly Gly
                85                  90                  95      
Gly Gly Gly Gly Gly Gly Thr Arg Gly Glu Gly Gly Glu Gln Glu Arg
            100                 105                 110         
Glu Glu Glu Asp Leu Asp Pro Phe Pro Pro Ala Arg Thr Arg Ala Ala
        115                 120                 125             
Pro Ala Thr Ala Thr Arg Arg Arg Cys Pro Leu Ser Ile Ser Pro Pro
    130                 135                 140                 
Ala Pro Thr Arg Asp Pro Gly Leu Ser Ala Gln Lys Val Pro Lys Thr
145                 150                 155                 160 
Ala Glu Asn Phe His Ala Leu Asn Phe His Ala Phe Met Glu Arg Thr
                165                 170                 175     
Asp Leu Val Ile Arg Val Pro Ala Phe Thr Glu Ile Phe Gln Gly Phe
            180                 185                 190         
Met Cys Gln Gly Gly Asp Phe Thr Tyr His Asn Asp Thr Gly Gly Lys
        195                 200                 205             
Ser Ile Tyr Arg Glu Lys Phe Asp Asp Glu Asn Phe Ile Leu Lys His
    210                 215                 220                 
Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Met Asn
225                 230                 235                 240 
Gly Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly
                245                 250                 255     
Lys His Val Val Phe Gly Lys Val Lys Glu Gly Met Lys Ile Met Glu
            260                 265                 270         
Ala Met Glu Arg Phe Gly Ala Ala Ser Gln Gln Arg Gln Ser Phe Asp
        275                 280                 285             
Ile Ser Ser Gly Lys Leu Asp Arg Gln Leu Lys Ser Ser Cys Pro Gln
    290                 295                 300                 
Cys Asp Lys Tyr Arg Gly Lys Gln Val Cys Asn Ser Glu His Lys Trp
305                 310                 315                 320 
Arg Asn Met Lys Gln Val His His Asp Gly Ser Thr Gly Leu Val Gly
                325                 330                 335     
Ala Phe Ile Ser Pro Leu Gly Glu Thr Glu His Asp Ser Pro Lys Ile
            340                 345                 350         
Ser Gln Thr Ile Trp Leu Pro Gly Asp Ala His Ala Leu Leu Ser Val
        355                 360                 365             
Gly Gly His Arg Gly Phe Arg Ile Leu Gly Thr Asn Pro Glu Leu Ala
    370                 375                 380                 
Arg Asp Gly Arg Arg Lys Ala Ser Cys Trp Val Arg Glu Gly Glu Leu
385                 390                 395                 400 
Glu Asn Lys Thr Ala Gln Arg Gln Phe Gly Ser His Gly Ile Pro Ala
                405                 410                 415     
Pro Thr Arg Gly Lys Glu Lys Ile Glu Asp Val Phe Phe Thr Glu Ala
            420                 425                 430         
Ser Ser Pro Trp Met His Leu Ala Ala Asp Pro Gln Pro Ala Leu Ser
        435                 440                 445             
Thr Ser Val Ser Ala Ser Gly Leu Ser Ser Cys Phe Leu Ser Ile Leu
    450                 455                 460                 
Leu Val
465     


<210> 8265
<211> 179
<212> PRT
<213> Homo sapiens

<400> 8265
Met Gln Thr Leu Ile Arg Lys Val Asn Lys Asn Tyr Tyr Ala Ser Met
 1               5                  10                  15      
Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asn Ser Glu Pro Leu
            20                  25                  30          
Gly Cys Val Ser Phe Glu Leu Phe Ala Asp Lys Leu Pro Lys Thr Ala
        35                  40                  45              
Glu Asn Phe His Ala Leu Ser Thr Gly Glu Lys Gly Phe Asp Tyr Glu
    50                  55                  60                  
Gly Tyr Cys Phe His Arg Ile Ile Pro Gly Phe Val Cys Gln Gly Gly
65                  70                  75                  80  
Asp Phe Thr Cys His Asn Gly Thr Gly Ser Lys Ser Ile Tyr Arg Glu
                85                  90                  95      
Lys Phe Asp Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile
            100                 105                 110         
Leu Ser Met Ala Asn Ala Gly Pro Asn Ala Asn Gly Ser Gln Phe Phe
        115                 120                 125             
Met Cys Pro Ala Lys Thr Lys Trp Leu Asp Gly Lys Gln Val Val Phe
    130                 135                 140                 
Gly Arg Val Lys Glu Gly Met Asp Ile Val Glu Ala Met Glu Arg Phe
145                 150                 155                 160 
Val Phe Arg Asn Gly Lys Thr Ser Lys Lys Val Thr Ile Ala Asp Cys
                165                 170                 175     
Gly Gln Leu
            


<210> 8266
<211> 101
<212> PRT
<213> Homo sapiens

<400> 8266
Met Trp Leu Leu Glu Asn Leu Asp Ser Gly Asn Cys Glu Leu Pro Phe
 1               5                  10                  15      
Ser Ile Tyr Val Glu Lys Phe Asn Asn Glu Asn Phe Ile Leu Lys His
            20                  25                  30          
Thr Gly Pro Gly Ile Leu Ser Met Ala Asn Ala Gly Pro Ile Thr Asn
        35                  40                  45              
Ser Ser Gln Phe Phe Ile Cys Thr Ala Lys Thr Gln Trp Leu His Gly
    50                  55                  60                  
Lys Asp Val Val Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu
65                  70                  75                  80  
Ala Met Lys Arg Phe Gly Ser Ser Gly Lys Thr Ser Lys Lys Ile Thr
                85                  90                  95      
Ile Ala Asp Cys Gly
            100     


<210> 8267
<211> 158
<212> PRT
<213> Homo sapiens

<400> 8267
Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Ile Asp Glu Pro
 1               5                  10                  15      
Leu Gly Arg Val Ser Phe Lys Leu Phe Ala Asp Lys Phe Pro Lys Thr
            20                  25                  30          
Thr Glu Asn Phe His Ala Leu Ser Thr Gly Glu Lys Gly Tyr Gly Tyr
        35                  40                  45              
Lys Gly Ser Cys Phe His Ser Ile Ile Pro Gly Phe Met Cys Gln Gly
    50                  55                  60                  
Gly Asp Phe Thr Leu Leu Asn Gly Thr Gly Gly Lys Ser Ile Tyr Arg
65                  70                  75                  80  
Glu Lys Phe Asp Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly
                85                  90                  95      
Ile Leu Ser Met Ala Asn Ala Gly Leu Asn Thr Asn Gly Ser Gln Phe
            100                 105                 110         
Phe Ile Cys Thr Ala Lys Thr Glu Trp Trp Met Ala Ala Cys Gly Leu
        115                 120                 125             
Trp Gln Gly Glu Arg Arg His Glu Asp Cys Gly Gly His Gly Ala Leu
    130                 135                 140                 
Ser Val Gln Glu Trp Gln Asp Gln Gln Glu Asp His His Cys
145                 150                 155             


<210> 8268
<211> 228
<212> PRT
<213> Homo sapiens

<400> 8268
Met Glu Arg Val Lys Met Ile Asn Val Gln Arg Leu Leu Glu Ala Ala
 1               5                  10                  15      
Glu Phe Leu Glu Arg Arg Glu Arg Glu Cys Glu His Gly Tyr Ala Ser
            20                  25                  30          
Ser Phe Pro Ser Met Pro Ser Pro Arg Leu Gln His Ser Lys Pro Pro
        35                  40                  45              
Arg Arg Leu Ser Arg Ala Gln Lys His Ser Ser Gly Thr Ser Asn Thr
    50                  55                  60                  
Ser Thr Ala Asn Arg Ser Thr His Asn Glu Leu Glu Lys Asn Arg Arg
65                  70                  75                  80  
Ala His Leu Arg Leu Cys Leu Glu Arg Leu Lys Val Leu Ile Pro Leu
                85                  90                  95      
Gly Pro Asp Cys Thr Arg His Thr Thr Leu Gly Leu Leu Asn Lys Ala
            100                 105                 110         
Lys Ala His Ile Lys Lys Leu Glu Glu Ala Glu Arg Lys Ser Gln His
        115                 120                 125             
Gln Leu Glu Asn Leu Glu Arg Glu Gln Arg Phe Leu Lys Trp Arg Leu
    130                 135                 140                 
Glu Gln Leu Gln Gly Pro Gln Glu Met Glu Arg Ile Arg Met Asp Ser
145                 150                 155                 160 
Ile Gly Ser Thr Ile Ser Ser Asp Arg Ser Asp Ser Glu Arg Glu Glu
                165                 170                 175     
Ile Glu Val Asp Val Glu Ser Thr Glu Phe Ser His Gly Glu Val Asp
            180                 185                 190         
Asn Ile Ser Thr Thr Ser Ile Ser Asp Ile Asp Asp His Ser Ser Leu
        195                 200                 205             
Pro Ser Ile Gly Ser Asp Glu Gly Tyr Ser Ser Ala Ser Val Lys Leu
    210                 215                 220                 
Ser Phe Thr Ser
225             


<210> 8269
<211> 182
<212> PRT
<213> Homo sapiens

<400> 8269
Met Pro Ser Pro Arg Leu Gln His Ser Lys Pro Pro Arg Arg Leu Ser
 1               5                  10                  15      
Arg Ala Gln Lys His Ser Ser Gly Ser Ser Asn Thr Ser Thr Ala Asn
            20                  25                  30          
Arg Arg Ala His Leu Arg Leu Cys Leu Glu Arg Leu Lys Val Leu Ile
        35                  40                  45              
Pro Leu Gly Pro Asp Cys Thr Arg His Thr Thr Leu Gly Leu Leu Asn
    50                  55                  60                  
Lys Ala Lys Ala His Ile Lys Lys Leu Glu Glu Ala Glu Arg Lys Ser
65                  70                  75                  80  
Gln His Gln Leu Glu Asn Leu Glu Arg Glu Gln Arg Phe Leu Lys Trp
                85                  90                  95      
Arg Leu Glu Gln Leu Gln Gly Pro Gln Glu Met Glu Arg Ile Arg Met
            100                 105                 110         
Asp Ser Ile Gly Ser Thr Ile Ser Ser Asp Arg Ser Asp Ser Glu Arg
        115                 120                 125             
Glu Glu Ile Glu Val Asp Val Glu Ser Thr Glu Phe Ser His Gly Glu
    130                 135                 140                 
Val Asp Asn Ile Ser Thr Thr Ser Ile Ser Asp Ile Asp Asp His Ser
145                 150                 155                 160 
Ser Leu Pro Ser Ile Gly Ser Asp Glu Gly Tyr Ser Ser Ala Ser Val
                165                 170                 175     
Lys Leu Ser Phe Thr Ser
            180         


<210> 8270
<211> 3899
<212> PRT
<213> Homo sapiens

<400> 8270
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys
 1               5                  10                  15      
Leu Ala Gln Phe Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro
            20                  25                  30          
Ser Lys Lys Gln Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp
        35                  40                  45              
Val Ser Ala His His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu
    50                  55                  60                  
Met Tyr Ile Asn Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu
65                  70                  75                  80  
Ser Thr Ile Met Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu
                85                  90                  95      
Gln Gly Phe Ser Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp
            100                 105                 110         
Asp Cys Ser Ser Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly
        115                 120                 125             
Lys Pro Thr Asn Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser
    130                 135                 140                 
Tyr Ser Glu Gln Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met
145                 150                 155                 160 
Glu Ser Glu Leu Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg
                165                 170                 175     
Glu Leu Glu Glu Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln
            180                 185                 190         
Leu Gln Glu Phe Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr
        195                 200                 205             
Gln Leu Thr Ala Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr
    210                 215                 220                 
Met Arg Glu Phe Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile
225                 230                 235                 240 
Gln Phe Gln Gln Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His
                245                 250                 255     
Ser Ser Thr Ala Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr
            260                 265                 270         
His Gln Gln Gln Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln
        275                 280                 285             
Lys Lys Lys Glu Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys
    290                 295                 300                 
Ile Lys Val Tyr Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn
305                 310                 315                 320 
Lys Glu Glu Ile Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr
                325                 330                 335     
Lys Ile Ile Glu Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu
            340                 345                 350         
Thr Thr Ala Asp Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln
        355                 360                 365             
Lys Asn Gln Glu Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys
    370                 375                 380                 
Gln Lys Glu Arg Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr
385                 390                 395                 400 
Val Glu Glu Leu Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr
                405                 410                 415     
Asp Ile Val Gln Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln
            420                 425                 430         
Leu Arg Ala Glu Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met
        435                 440                 445             
Lys Gln Glu Leu Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys
    450                 455                 460                 
Thr Arg His Lys Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn
465                 470                 475                 480 
Ile Thr Val Asn Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn
                485                 490                 495     
Glu Leu Asn Ile Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu
            500                 505                 510         
Lys Glu Glu Leu Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg
        515                 520                 525             
Gln Leu Glu Asp Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile
    530                 535                 540                 
Gln Arg Ala Arg Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu
545                 550                 555                 560 
Ala His Lys Ser Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val
                565                 570                 575     
Ser Ala Ser Glu Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu
            580                 585                 590         
Val Thr Asn Tyr Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn
        595                 600                 605             
Ala Val Leu Asp Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg
    610                 615                 620                 
Leu Arg Thr Gln Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu
625                 630                 635                 640 
Lys Glu Asp Leu Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys
                645                 650                 655     
Asp Asn Leu Gly Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn
            660                 665                 670         
Glu Met Ser Gln Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu
        675                 680                 685             
Ile Thr Lys Gln Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp
    690                 695                 700                 
Leu Gln Gln Ser Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln
705                 710                 715                 720 
Ile Asn Glu Leu Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys
                725                 730                 735     
Glu Lys Gly Thr Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr
            740                 745                 750         
Glu Leu Leu Glu Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu
        755                 760                 765             
Lys Phe Ala Gln Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys
    770                 775                 780                 
Lys Thr Leu Glu Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu
785                 790                 795                 800 
Glu Arg Leu Ile Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser
                805                 810                 815     
Val Trp Glu Lys Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu
            820                 825                 830         
Lys Gln Gln Cys Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn
        835                 840                 845             
Thr Phe Ser Phe Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu
    850                 855                 860                 
Gln Glu Glu Tyr Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp
865                 870                 875                 880 
Ser Lys Asn Lys Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu
                885                 890                 895     
Asn Glu Glu Leu His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met
            900                 905                 910         
Lys Ser Ser Val Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu
        915                 920                 925             
Glu Met Gly Glu Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys
    930                 935                 940                 
Leu Glu Val Thr Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser
945                 950                 955                 960 
Asp Leu Ser Glu Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu
                965                 970                 975     
Asn Glu Glu Val Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu
            980                 985                 990         
Arg Cys Arg Glu Leu Glu Ile Ile Ile Asn His Asn Arg Ala Glu Asn
        995                 1000                1005            
Val Gln Ser Cys Asp Thr Gln Val Ser Ser Leu Leu Asp Gly Val Val
    1010                1015                1020                
Thr Met Thr Ser Arg Gly Ala Glu Gly Ser Val Ser Lys Val Asn Lys
1025                1030                1035                1040
Ser Phe Gly Glu Glu Ser Lys Ile Met Val Glu Asp Lys Val Ser Phe
                1045                1050                1055    
Glu Asn Met Thr Val Gly Glu Glu Ser Lys Gln Glu Gln Leu Ile Leu
            1060                1065                1070        
Asp His Leu Pro Ser Val Thr Lys Glu Ser Ser Leu Arg Ala Thr Gln
        1075                1080                1085            
Pro Ser Glu Asn Asp Lys Leu Gln Lys Glu Leu Asn Val Leu Lys Ser
    1090                1095                1100                
Glu Gln Asn Asp Leu Arg Leu Gln Met Glu Ala Gln Arg Ile Cys Leu
1105                1110                1115                1120
Ser Leu Val Tyr Ser Thr His Val Asp Gln Val Arg Glu Tyr Met Glu
                1125                1130                1135    
Asn Glu Lys Asp Lys Ala Leu Cys Ser Leu Lys Glu Glu Leu Ile Phe
            1140                1145                1150        
Ala Gln Glu Glu Lys Ile Lys Glu Leu Gln Lys Ile His Gln Leu Glu
        1155                1160                1165            
Leu Gln Thr Met Lys Thr Gln Glu Thr Gly Asp Glu Gly Lys Pro Leu
    1170                1175                1180                
His Leu Leu Ile Gly Lys Leu Gln Lys Ala Val Ser Glu Glu Cys Ser
1185                1190                1195                1200
Tyr Phe Leu Gln Thr Leu Cys Ser Val Leu Gly Glu Tyr Tyr Thr Pro
                1205                1210                1215    
Ala Leu Lys Cys Glu Val Asn Ala Glu Asp Lys Glu Asn Ser Gly Asp
            1220                1225                1230        
Tyr Ile Ser Glu Asn Glu Asp Pro Glu Leu Gln Asp Tyr Arg Tyr Glu
        1235                1240                1245            
Val Gln Asp Phe Gln Glu Asn Met His Thr Leu Leu Asn Lys Val Thr
    1250                1255                1260                
Glu Glu Tyr Asn Lys Leu Leu Val Leu Gln Thr Arg Leu Ser Lys Ile
1265                1270                1275                1280
Trp Gly Gln Gln Thr Asp Gly Met Lys Leu Glu Phe Gly Glu Glu Asn
                1285                1290                1295    
Leu Pro Lys Glu Glu Thr Glu Phe Leu Ser Ile His Ser Gln Met Thr
            1300                1305                1310        
Asn Leu Glu Asp Ile Asp Val Asn His Lys Ser Lys Leu Ser Ser Leu
        1315                1320                1325            
Gln Asp Leu Glu Lys Thr Lys Leu Glu Glu Gln Val Gln Glu Leu Glu
    1330                1335                1340                
Ser Leu Ile Ser Ser Leu Gln Gln Gln Leu Lys Glu Thr Glu Gln Asn
1345                1350                1355                1360
Tyr Glu Ala Glu Ile His Cys Leu Gln Lys Arg Leu Gln Ala Val Ser
                1365                1370                1375    
Glu Ser Thr Val Pro Pro Ser Leu Pro Val Asp Ser Val Val Ile Thr
            1380                1385                1390        
Glu Ser Asp Ala Gln Arg Thr Met Tyr Pro Gly Ser Cys Val Lys Lys
        1395                1400                1405            
Asn Ile Asp Gly Thr Ile Glu Phe Ser Gly Glu Phe Gly Val Lys Glu
    1410                1415                1420                
Glu Thr Asn Ile Val Lys Leu Leu Glu Lys Gln Tyr Gln Glu Gln Leu
1425                1430                1435                1440
Glu Glu Glu Val Ala Lys Val Ile Val Ser Met Ser Ile Ala Phe Ala
                1445                1450                1455    
Gln Gln Thr Glu Leu Ser Arg Ile Ser Gly Gly Lys Glu Asn Thr Ala
            1460                1465                1470        
Ser Ser Lys Gln Ala His Ala Val Cys Gln Gln Glu Gln His Tyr Phe
        1475                1480                1485            
Asn Glu Met Lys Leu Ser Gln Asp Gln Ile Gly Phe Gln Thr Phe Glu
    1490                1495                1500                
Thr Val Asp Val Lys Phe Lys Glu Glu Phe Lys Pro Leu Ser Lys Glu
1505                1510                1515                1520
Leu Gly Glu His Gly Lys Glu Ile Leu Leu Ser Asn Ser Asp Pro His
                1525                1530                1535    
Asp Ile Pro Glu Ser Lys Asp Cys Val Leu Thr Ile Ser Glu Glu Met
            1540                1545                1550        
Phe Ser Lys Asp Lys Thr Phe Ile Val Arg Gln Ser Ile His Asp Glu
        1555                1560                1565            
Ile Ser Val Ser Ser Met Asp Ala Ser Arg Gln Leu Met Leu Asn Glu
    1570                1575                1580                
Glu Gln Leu Glu Asp Met Arg Gln Glu Leu Val Arg Gln Tyr Gln Glu
1585                1590                1595                1600
His Gln Gln Ala Thr Glu Leu Leu Arg Gln Ala His Met Arg Gln Met
                1605                1610                1615    
Glu Arg Gln Arg Glu Asp Gln Glu Gln Leu Gln Glu Glu Ile Lys Arg
            1620                1625                1630        
Leu Asn Arg Gln Leu Ala Gln Arg Ser Ser Ile Asp Asn Glu Asn Leu
        1635                1640                1645            
Val Ser Glu Arg Glu Arg Val Leu Leu Glu Glu Leu Glu Ala Leu Lys
    1650                1655                1660                
Gln Leu Ser Leu Ala Gly Arg Glu Lys Leu Cys Cys Glu Leu Arg Asn
1665                1670                1675                1680
Ser Ser Thr Gln Thr Gln Asn Gly Asn Glu Asn Gln Gly Glu Val Glu
                1685                1690                1695    
Glu Gln Thr Phe Lys Glu Lys Glu Leu Asp Arg Lys Pro Glu Asp Val
            1700                1705                1710        
Pro Pro Glu Ile Leu Ser Asn Glu Arg Tyr Ala Leu Gln Lys Ala Asn
        1715                1720                1725            
Asn Arg Leu Leu Lys Ile Leu Leu Glu Val Val Lys Thr Thr Ala Ala
    1730                1735                1740                
Val Glu Glu Thr Ile Gly Arg His Val Leu Gly Ile Leu Asp Arg Ser
1745                1750                1755                1760
Ser Lys Ser Gln Ser Ser Ala Ser Leu Ile Trp Arg Ser Glu Ala Glu
                1765                1770                1775    
Ala Ser Val Lys Ser Cys Val His Glu Glu His Thr Arg Val Thr Asp
            1780                1785                1790        
Glu Ser Ile Pro Ser Tyr Ser Gly Ser Asp Met Pro Arg Asn Asp Ile
        1795                1800                1805            
Asn Met Trp Ser Lys Val Thr Glu Glu Gly Thr Glu Leu Ser Gln Arg
    1810                1815                1820                
Leu Val Arg Ser Gly Phe Ala Gly Thr Glu Ile Asp Pro Glu Asn Glu
1825                1830                1835                1840
Glu Leu Met Leu Asn Ile Ser Ser Arg Leu Gln Ala Ala Val Glu Lys
                1845                1850                1855    
Leu Leu Glu Ala Ile Ser Glu Thr Ser Ser Gln Leu Glu His Ala Lys
            1860                1865                1870        
Val Thr Gln Thr Glu Leu Met Arg Glu Ser Phe Arg Gln Lys Gln Glu
        1875                1880                1885            
Ala Thr Glu Ser Leu Lys Cys Gln Glu Glu Leu Arg Glu Arg Leu His
    1890                1895                1900                
Glu Glu Ser Arg Ala Arg Glu Gln Leu Ala Val Glu Leu Ser Lys Ala
1905                1910                1915                1920
Glu Gly Val Ile Asp Gly Tyr Ala Asp Glu Lys Thr Leu Phe Glu Arg
                1925                1930                1935    
Gln Ile Gln Glu Lys Thr Asp Ile Ile Asp Arg Leu Glu Gln Glu Leu
            1940                1945                1950        
Leu Cys Ala Ser Asn Arg Leu Gln Glu Leu Glu Ala Glu Gln Gln Gln
        1955                1960                1965            
Ile Gln Glu Glu Arg Glu Leu Leu Ser Arg Gln Lys Glu Ala Met Lys
    1970                1975                1980                
Ala Glu Ala Gly Pro Val Glu Gln Gln Leu Leu Gln Glu Thr Glu Lys
1985                1990                1995                2000
Leu Met Lys Glu Lys Leu Glu Val Gln Cys Gln Ala Glu Lys Val Arg
                2005                2010                2015    
Asp Asp Leu Gln Lys Gln Val Lys Ala Leu Glu Ile Asp Val Glu Glu
            2020                2025                2030        
Gln Val Ser Arg Phe Ile Glu Leu Glu Gln Glu Lys Asn Thr Glu Leu
        2035                2040                2045            
Met Asp Leu Arg Gln Gln Asn Gln Ala Leu Glu Lys Gln Leu Glu Lys
    2050                2055                2060                
Met Arg Lys Phe Leu Asp Glu Gln Ala Ile Asp Arg Glu His Glu Arg
2065                2070                2075                2080
Asp Val Phe Gln Gln Glu Ile Gln Lys Leu Glu Gln Gln Leu Lys Val
                2085                2090                2095    
Val Pro Arg Phe Gln Pro Ile Ser Glu His Gln Thr Arg Glu Val Glu
            2100                2105                2110        
Gln Leu Ala Asn His Leu Lys Glu Lys Thr Asp Lys Cys Ser Glu Leu
        2115                2120                2125            
Leu Leu Ser Lys Glu Gln Leu Gln Arg Asp Ile Gln Glu Arg Asn Glu
    2130                2135                2140                
Glu Ile Glu Lys Leu Glu Phe Arg Val Arg Glu Leu Glu Gln Ala Leu
2145                2150                2155                2160
Leu Val Glu Asp Arg Lys His Phe Gly Ala Val Glu Ala Lys Pro Glu
                2165                2170                2175    
Leu Ser Leu Glu Val Gln Leu Gln Ala Glu Arg Asp Ala Ile Asp Arg
            2180                2185                2190        
Lys Glu Lys Glu Ile Thr Asn Leu Glu Glu Gln Leu Glu Gln Phe Arg
        2195                2200                2205            
Glu Glu Leu Glu Asn Lys Asn Glu Glu Val Gln Gln Leu His Met Gln
    2210                2215                2220                
Leu Glu Ile Gln Lys Lys Glu Ser Thr Thr Arg Leu Gln Glu Leu Glu
2225                2230                2235                2240
Gln Glu Asn Lys Leu Phe Lys Asp Asp Met Glu Lys Leu Gly Leu Ala
                2245                2250                2255    
Ile Lys Glu Ser Asp Ala Met Ser Thr Gln Asp Gln His Val Leu Phe
            2260                2265                2270        
Gly Lys Phe Ala Gln Ile Ile Gln Glu Lys Glu Val Glu Ile Asp Gln
        2275                2280                2285            
Leu Asn Glu Gln Val Thr Lys Leu Gln Gln Gln Leu Lys Ile Thr Thr
    2290                2295                2300                
Asp Asn Lys Val Ile Glu Glu Lys Asn Glu Leu Ile Arg Asp Leu Glu
2305                2310                2315                2320
Thr Gln Ile Glu Cys Leu Met Ser Asp Gln Glu Cys Val Lys Arg Asn
                2325                2330                2335    
Arg Glu Glu Glu Ile Glu Gln Leu Asn Glu Val Ile Glu Lys Leu Gln
            2340                2345                2350        
Gln Glu Leu Ala Asn Ile Gly Gln Lys Thr Ser Met Asn Ala His Ser
        2355                2360                2365            
Leu Ser Glu Glu Ala Asp Ser Leu Lys His Gln Leu Asp Val Val Ile
    2370                2375                2380                
Ala Glu Lys Leu Ala Leu Glu Gln Gln Val Glu Thr Ala Asn Glu Glu
2385                2390                2395                2400
Met Thr Phe Met Lys Asn Val Leu Lys Glu Thr Asn Phe Lys Met Asn
                2405                2410                2415    
Gln Leu Thr Gln Glu Leu Phe Ser Leu Lys Arg Glu Arg Glu Ser Val
            2420                2425                2430        
Glu Lys Ile Gln Ser Ile Pro Glu Asn Ser Val Asn Val Ala Ile Asp
        2435                2440                2445            
His Leu Ser Lys Asp Lys Pro Glu Leu Glu Val Val Leu Thr Glu Asp
    2450                2455                2460                
Ala Leu Lys Ser Leu Glu Asn Gln Thr Tyr Phe Lys Ser Phe Glu Glu
2465                2470                2475                2480
Asn Gly Lys Gly Ser Ile Ile Asn Leu Glu Thr Arg Leu Leu Gln Leu
                2485                2490                2495    
Glu Ser Thr Val Ser Ala Lys Asp Leu Glu Leu Thr Gln Cys Tyr Lys
            2500                2505                2510        
Gln Ile Lys Asp Met Gln Glu Gln Gly Gln Phe Glu Thr Glu Met Leu
        2515                2520                2525            
Gln Lys Lys Ile Val Asn Leu Gln Lys Ile Val Glu Glu Lys Val Ala
    2530                2535                2540                
Ala Ala Leu Val Ser Gln Ile Gln Leu Glu Ala Val Gln Glu Tyr Ala
2545                2550                2555                2560
Lys Phe Cys Gln Asp Asn Gln Thr Ile Ser Ser Glu Pro Glu Arg Thr
                2565                2570                2575    
Asn Ile Gln Asn Leu Asn Gln Leu Arg Glu Asp Glu Leu Gly Ser Asp
            2580                2585                2590        
Ile Ser Ala Leu Thr Leu Arg Ile Ser Glu Leu Glu Ser Gln Val Val
        2595                2600                2605            
Glu Met His Thr Ser Leu Ile Leu Glu Lys Glu Gln Val Glu Ile Ala
    2610                2615                2620                
Glu Lys Asn Val Leu Glu Lys Glu Lys Lys Leu Leu Glu Leu Gln Lys
2625                2630                2635                2640
Leu Leu Glu Gly Asn Glu Lys Lys Gln Arg Glu Lys Glu Lys Lys Arg
                2645                2650                2655    
Ser Pro Gln Asp Val Glu Val Leu Lys Thr Thr Thr Glu Leu Phe His
            2660                2665                2670        
Ser Asn Glu Glu Ser Gly Phe Phe Asn Glu Leu Glu Ala Leu Arg Ala
        2675                2680                2685            
Glu Ser Val Ala Thr Lys Ala Glu Leu Ala Ser Tyr Lys Glu Lys Ala
    2690                2695                2700                
Glu Lys Leu Gln Glu Glu Leu Leu Val Lys Glu Thr Asn Met Thr Ser
2705                2710                2715                2720
Leu Gln Lys Asp Leu Ser Gln Val Arg Asp His Leu Ala Glu Ala Lys
                2725                2730                2735    
Glu Lys Leu Ser Ile Leu Glu Lys Glu Asp Glu Thr Glu Val Gln Glu
            2740                2745                2750        
Ser Lys Lys Ala Cys Met Phe Glu Pro Leu Pro Ile Lys Leu Ser Lys
        2755                2760                2765            
Ser Ile Ala Ser Gln Thr Asp Gly Thr Leu Lys Ile Ser Ser Ser Asn
    2770                2775                2780                
Gln Thr Pro Gln Ile Leu Val Lys Asn Ala Gly Ile Gln Ile Asn Leu
2785                2790                2795                2800
Gln Ser Glu Cys Ser Ser Glu Glu Val Thr Glu Ile Ile Ser Gln Phe
                2805                2810                2815    
Thr Glu Lys Ile Glu Lys Met Gln Glu Leu His Ala Ala Glu Ile Leu
            2820                2825                2830        
Asp Met Glu Ser Arg His Ile Ser Glu Thr Glu Thr Leu Lys Arg Glu
        2835                2840                2845            
His Tyr Val Ala Val Gln Leu Leu Lys Glu Glu Cys Gly Thr Leu Lys
    2850                2855                2860                
Ala Val Ile Gln Cys Leu Arg Ser Lys Glu Gly Ser Ser Ile Pro Glu
2865                2870                2875                2880
Leu Ala His Ser Asp Ala Tyr Gln Thr Arg Glu Ile Cys Ser Ser Asp
                2885                2890                2895    
Ser Gly Ser Asp Trp Gly Gln Gly Ile Tyr Leu Thr His Ser Gln Gly
            2900                2905                2910        
Phe Asp Ile Ala Ser Glu Gly Arg Gly Glu Glu Ser Glu Ser Ala Thr
        2915                2920                2925            
Asp Ser Phe Pro Lys Lys Ile Lys Gly Leu Leu Arg Ala Val His Asn
    2930                2935                2940                
Glu Gly Met Gln Val Leu Ser Leu Thr Glu Ser Pro Tyr Ser Asp Gly
2945                2950                2955                2960
Glu Asp His Ser Ile Gln Gln Val Ser Glu Pro Trp Leu Glu Glu Arg
                2965                2970                2975    
Lys Ala Tyr Ile Asn Thr Ile Ser Ser Leu Lys Asp Leu Ile Thr Lys
            2980                2985                2990        
Met Gln Leu Gln Arg Glu Ala Glu Val Tyr Asp Ser Ser Gln Ser His
        2995                3000                3005            
Glu Ser Phe Ser Asp Trp Arg Gly Glu Leu Leu Leu Ala Leu Gln Gln
    3010                3015                3020                
Val Phe Leu Glu Glu Arg Ser Val Leu Leu Ala Ala Phe Arg Thr Glu
3025                3030                3035                3040
Leu Thr Ala Leu Gly Thr Thr Asp Ala Val Gly Leu Leu Asn Cys Leu
                3045                3050                3055    
Glu Gln Arg Ile Gln Glu Gln Gly Val Glu Tyr Gln Ala Ala Met Glu
            3060                3065                3070        
Cys Leu Gln Lys Ala Asp Arg Arg Ser Leu Leu Ser Glu Ile Gln Ala
        3075                3080                3085            
Leu His Ala Gln Met Asn Gly Arg Lys Ile Thr Leu Lys Arg Glu Gln
    3090                3095                3100                
Glu Ser Glu Lys Pro Ser Gln Glu Leu Leu Glu Tyr Asn Ile Gln Gln
3105                3110                3115                3120
Lys Gln Ser Gln Met Leu Glu Met Gln Val Glu Leu Ser Ser Met Lys
                3125                3130                3135    
Asp Arg Ala Thr Glu Leu Gln Glu Gln Leu Ser Ser Glu Lys Met Val
            3140                3145                3150        
Val Ala Glu Leu Lys Ser Glu Leu Ala Gln Thr Lys Leu Glu Leu Glu
        3155                3160                3165            
Thr Thr Leu Lys Ala Gln His Lys His Leu Lys Glu Leu Glu Ala Phe
    3170                3175                3180                
Arg Leu Glu Val Lys Asp Lys Thr Asp Glu Val His Leu Leu Asn Asp
3185                3190                3195                3200
Thr Leu Ala Ser Glu Gln Lys Lys Ser Arg Glu Leu Gln Trp Ala Leu
                3205                3210                3215    
Glu Lys Glu Lys Ala Lys Leu Gly Arg Ser Glu Glu Arg Asp Lys Glu
            3220                3225                3230        
Glu Leu Glu Asp Leu Lys Phe Ser Leu Glu Ser Gln Lys Gln Arg Asn
        3235                3240                3245            
Leu Gln Leu Asn Leu Leu Leu Glu Gln Gln Lys Gln Leu Leu Asn Glu
    3250                3255                3260                
Ser Gln Gln Lys Ile Glu Ser Gln Arg Met Leu Tyr Asp Ala Gln Leu
3265                3270                3275                3280
Ser Glu Glu Gln Gly Arg Asn Leu Glu Leu Gln Val Leu Leu Glu Ser
                3285                3290                3295    
Glu Lys Val Arg Ile Arg Glu Met Ser Ser Thr Leu Asp Arg Glu Arg
            3300                3305                3310        
Glu Leu His Ala Gln Leu Gln Ser Ser Asp Gly Thr Gly Gln Ser Arg
        3315                3320                3325            
Pro Pro Leu Pro Ser Glu Asp Leu Leu Lys Glu Leu Gln Lys Gln Leu
    3330                3335                3340                
Glu Glu Lys His Ser Arg Ile Val Glu Leu Leu Asn Glu Thr Glu Lys
3345                3350                3355                3360
Tyr Lys Leu Asp Ser Leu Gln Thr Arg Gln Gln Met Glu Lys Asp Arg
                3365                3370                3375    
Gln Val His Arg Lys Thr Leu Gln Thr Glu Gln Glu Ala Asn Thr Glu
            3380                3385                3390        
Gly Gln Lys Lys Met His Glu Leu Gln Ser Lys Val Glu Asp Leu Gln
        3395                3400                3405            
Arg Gln Leu Glu Glu Lys Arg Gln Gln Val Tyr Lys Leu Asp Leu Glu
    3410                3415                3420                
Gly Gln Arg Leu Gln Gly Ile Met Gln Glu Phe Gln Lys Gln Glu Leu
3425                3430                3435                3440
Glu Arg Glu Glu Lys Arg Glu Ser Arg Arg Ile Leu Tyr Gln Asn Leu
                3445                3450                3455    
Asn Glu Pro Thr Thr Trp Ser Leu Thr Ser Asp Arg Thr Arg Asn Trp
            3460                3465                3470        
Val Leu Gln Gln Lys Ile Glu Gly Glu Thr Lys Glu Ser Asn Tyr Ala
        3475                3480                3485            
Lys Leu Ile Glu Met Asn Gly Gly Gly Thr Gly Cys Asn His Glu Leu
    3490                3495                3500                
Glu Met Ile Arg Gln Lys Leu Gln Cys Val Ala Ser Lys Leu Gln Val
3505                3510                3515                3520
Leu Pro Gln Lys Ala Ser Glu Arg Leu Gln Phe Glu Thr Ala Asp Asp
                3525                3530                3535    
Glu Asp Phe Ile Trp Val Gln Glu Asn Ile Asp Glu Ile Ile Leu Gln
            3540                3545                3550        
Leu Gln Lys Leu Thr Gly Gln Gln Gly Glu Glu Pro Ser Leu Val Ser
        3555                3560                3565            
Pro Ser Thr Ser Cys Gly Ser Leu Thr Glu Arg Leu Leu Arg Gln Asn
    3570                3575                3580                
Ala Glu Leu Thr Gly His Ile Ser Gln Leu Thr Glu Glu Lys Asn Asp
3585                3590                3595                3600
Leu Arg Asn Met Val Met Lys Leu Glu Glu Gln Ile Arg Trp Tyr Arg
                3605                3610                3615    
Gln Thr Gly Ala Gly Arg Asp Asn Ser Ser Arg Phe Ser Leu Asn Gly
            3620                3625                3630        
Gly Ala Asn Ile Glu Ala Ile Ile Ala Ser Glu Lys Glu Val Trp Asn
        3635                3640                3645            
Arg Glu Lys Leu Thr Leu Gln Lys Ser Leu Lys Arg Ala Glu Ala Glu
    3650                3655                3660                
Val Tyr Lys Leu Lys Ala Glu Leu Arg Asn Asp Ser Leu Leu Gln Thr
3665                3670                3675                3680
Leu Ser Pro Asp Ser Glu His Val Thr Leu Lys Arg Ile Tyr Gly Lys
                3685                3690                3695    
Tyr Leu Arg Ala Glu Ser Phe Arg Lys Ala Leu Ile Tyr Gln Lys Lys
            3700                3705                3710        
Tyr Leu Leu Leu Leu Leu Gly Gly Phe Gln Glu Cys Glu Asp Ala Thr
        3715                3720                3725            
Leu Ala Leu Leu Ala Arg Met Gly Gly Gln Pro Ala Phe Thr Asp Leu
    3730                3735                3740                
Glu Val Ile Thr Asn Arg Pro Lys Gly Phe Thr Arg Phe Arg Ser Ala
3745                3750                3755                3760
Val Arg Val Ser Ile Ala Ile Ser Arg Met Lys Phe Leu Val Arg Arg
                3765                3770                3775    
Trp His Arg Val Thr Gly Ser Val Ser Ile Asn Ile Asn Arg Asp Gly
            3780                3785                3790        
Phe Gly Leu Asn Gln Gly Ala Glu Lys Thr Asp Ser Phe Tyr His Ser
        3795                3800                3805            
Ser Gly Gly Leu Glu Leu Tyr Gly Glu Pro Arg His Thr Thr Tyr Arg
    3810                3815                3820                
Ser Arg Ser Asp Leu Asp Tyr Ile Arg Ser Pro Leu Pro Phe Gln Asn
3825                3830                3835                3840
Arg Tyr Pro Gly Thr Pro Ala Asp Phe Asn Pro Gly Ser Leu Ala Cys
                3845                3850                3855    
Ser Gln Leu Gln Asn Tyr Asp Pro Asp Arg Ala Leu Thr Asp Tyr Ile
            3860                3865                3870        
Thr Arg Leu Glu Ala Leu Gln Arg Arg Leu Gly Thr Ile Gln Ser Gly
        3875                3880                3885            
Ser Thr Thr Gln Phe His Ala Gly Met Arg Arg
    3890                3895                


<210> 8271
<211> 3911
<212> PRT
<213> Homo sapiens

<400> 8271
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys
 1               5                  10                  15      
Ile Glu Glu Leu Ser Leu Ala Phe Leu Val Arg Gln Leu Ala Gln Phe
            20                  25                  30          
Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln
        35                  40                  45              
Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp Val Ser Ala His
    50                  55                  60                  
His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn
65                  70                  75                  80  
Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu Ser Thr Ile Met
                85                  90                  95      
Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu Gln Gly Phe Ser
            100                 105                 110         
Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp Asp Cys Ser Ser
        115                 120                 125             
Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly Lys Pro Thr Asn
    130                 135                 140                 
Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln
145                 150                 155                 160 
Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met Glu Ser Glu Leu
                165                 170                 175     
Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu
            180                 185                 190         
Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln Leu Gln Glu Phe
        195                 200                 205             
Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr Gln Leu Thr Ala
    210                 215                 220                 
Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr Met Arg Glu Phe
225                 230                 235                 240 
Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln
                245                 250                 255     
Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His Ser Ser Thr Ala
            260                 265                 270         
Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr His Gln Gln Gln
        275                 280                 285             
Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu
    290                 295                 300                 
Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr
305                 310                 315                 320 
Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile
                325                 330                 335     
Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr Lys Ile Ile Glu
            340                 345                 350         
Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu Thr Thr Ala Asp
        355                 360                 365             
Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu
    370                 375                 380                 
Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys Gln Lys Glu Arg
385                 390                 395                 400 
Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr Val Glu Glu Leu
                405                 410                 415     
Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr Asp Ile Val Gln
            420                 425                 430         
Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu
        435                 440                 445             
Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu
    450                 455                 460                 
Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys Thr Arg His Lys
465                 470                 475                 480 
Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn Ile Thr Val Asn
                485                 490                 495     
Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile
            500                 505                 510         
Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu
        515                 520                 525             
Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp
    530                 535                 540                 
Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg
545                 550                 555                 560 
Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser
                565                 570                 575     
Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu
            580                 585                 590         
Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu Val Thr Asn Tyr
        595                 600                 605             
Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp
    610                 615                 620                 
Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Thr Gln
625                 630                 635                 640 
Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu
                645                 650                 655     
Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly
            660                 665                 670         
Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln
        675                 680                 685             
Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu Ile Thr Lys Gln
    690                 695                 700                 
Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser
705                 710                 715                 720 
Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln Ile Asn Glu Leu
                725                 730                 735     
Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Thr
            740                 745                 750         
Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr Glu Leu Leu Glu
        755                 760                 765             
Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln
    770                 775                 780                 
Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys Lys Thr Leu Glu
785                 790                 795                 800 
Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu Glu Arg Leu Ile
                805                 810                 815     
Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys
            820                 825                 830         
Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys
        835                 840                 845             
Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn Thr Phe Ser Phe
    850                 855                 860                 
Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr
865                 870                 875                 880 
Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys
                885                 890                 895     
Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu
            900                 905                 910         
His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met Lys Ser Ser Val
        915                 920                 925             
Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu Glu Met Gly Glu
    930                 935                 940                 
Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys Leu Glu Val Thr
945                 950                 955                 960 
Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu
                965                 970                 975     
Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val
            980                 985                 990         
Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu Arg Cys Arg Glu
        995                 1000                1005            
Leu Glu Ile Ile Ile Asn His Asn Arg Ala Glu Asn Val Gln Ser Cys
    1010                1015                1020                
Asp Thr Gln Val Ser Ser Leu Leu Asp Gly Val Val Thr Met Thr Ser
1025                1030                1035                1040
Arg Gly Ala Glu Gly Ser Val Ser Lys Val Asn Lys Ser Phe Gly Glu
                1045                1050                1055    
Glu Ser Lys Ile Met Val Glu Asp Lys Val Ser Phe Glu Asn Met Thr
            1060                1065                1070        
Val Gly Glu Glu Ser Lys Gln Glu Gln Leu Ile Leu Asp His Leu Pro
        1075                1080                1085            
Ser Val Thr Lys Glu Ser Ser Leu Arg Ala Thr Gln Pro Ser Glu Asn
    1090                1095                1100                
Asp Lys Leu Gln Lys Glu Leu Asn Val Leu Lys Ser Glu Gln Asn Asp
1105                1110                1115                1120
Leu Arg Leu Gln Met Glu Ala Gln Arg Ile Cys Leu Ser Leu Val Tyr
                1125                1130                1135    
Ser Thr His Val Asp Gln Val Arg Glu Tyr Met Glu Asn Glu Lys Asp
            1140                1145                1150        
Lys Ala Leu Cys Ser Leu Lys Glu Glu Leu Ile Phe Ala Gln Glu Glu
        1155                1160                1165            
Lys Ile Lys Glu Leu Gln Lys Ile His Gln Leu Glu Leu Gln Thr Met
    1170                1175                1180                
Lys Thr Gln Glu Thr Gly Asp Glu Gly Lys Pro Leu His Leu Leu Ile
1185                1190                1195                1200
Gly Lys Leu Gln Lys Ala Val Ser Glu Glu Cys Ser Tyr Phe Leu Gln
                1205                1210                1215    
Thr Leu Cys Ser Val Leu Gly Glu Tyr Tyr Thr Pro Ala Leu Lys Cys
            1220                1225                1230        
Glu Val Asn Ala Glu Asp Lys Glu Asn Ser Gly Asp Tyr Ile Ser Glu
        1235                1240                1245            
Asn Glu Asp Pro Glu Leu Gln Asp Tyr Arg Tyr Glu Val Gln Asp Phe
    1250                1255                1260                
Gln Glu Asn Met His Thr Leu Leu Asn Lys Val Thr Glu Glu Tyr Asn
1265                1270                1275                1280
Lys Leu Leu Val Leu Gln Thr Arg Leu Ser Lys Ile Trp Gly Gln Gln
                1285                1290                1295    
Thr Asp Gly Met Lys Leu Glu Phe Gly Glu Glu Asn Leu Pro Lys Glu
            1300                1305                1310        
Glu Thr Glu Phe Leu Ser Ile His Ser Gln Met Thr Asn Leu Glu Asp
        1315                1320                1325            
Ile Asp Val Asn His Lys Ser Lys Leu Ser Ser Leu Gln Asp Leu Glu
    1330                1335                1340                
Lys Thr Lys Leu Glu Glu Gln Val Gln Glu Leu Glu Ser Leu Ile Ser
1345                1350                1355                1360
Ser Leu Gln Gln Gln Leu Lys Glu Thr Glu Gln Asn Tyr Glu Ala Glu
                1365                1370                1375    
Ile His Cys Leu Gln Lys Arg Leu Gln Ala Val Ser Glu Ser Thr Val
            1380                1385                1390        
Pro Pro Ser Leu Pro Val Asp Ser Val Val Ile Thr Glu Ser Asp Ala
        1395                1400                1405            
Gln Arg Thr Met Tyr Pro Gly Ser Cys Val Lys Lys Asn Ile Asp Gly
    1410                1415                1420                
Thr Ile Glu Phe Ser Gly Glu Phe Gly Val Lys Glu Glu Thr Asn Ile
1425                1430                1435                1440
Val Lys Leu Leu Glu Lys Gln Tyr Gln Glu Gln Leu Glu Glu Glu Val
                1445                1450                1455    
Ala Lys Val Ile Val Ser Met Ser Ile Ala Phe Ala Gln Gln Thr Glu
            1460                1465                1470        
Leu Ser Arg Ile Ser Gly Gly Lys Glu Asn Thr Ala Ser Ser Lys Gln
        1475                1480                1485            
Ala His Ala Val Cys Gln Gln Glu Gln His Tyr Phe Asn Glu Met Lys
    1490                1495                1500                
Leu Ser Gln Asp Gln Ile Gly Phe Gln Thr Phe Glu Thr Val Asp Val
1505                1510                1515                1520
Lys Phe Lys Glu Glu Phe Lys Pro Leu Ser Lys Glu Leu Gly Glu His
                1525                1530                1535    
Gly Lys Glu Ile Leu Leu Ser Asn Ser Asp Pro His Asp Ile Pro Glu
            1540                1545                1550        
Ser Lys Asp Cys Val Leu Thr Ile Ser Glu Glu Met Phe Ser Lys Asp
        1555                1560                1565            
Lys Thr Phe Ile Val Arg Gln Ser Ile His Asp Glu Ile Ser Val Ser
    1570                1575                1580                
Ser Met Asp Ala Ser Arg Gln Leu Met Leu Asn Glu Glu Gln Leu Glu
1585                1590                1595                1600
Asp Met Arg Gln Glu Leu Val Arg Gln Tyr Gln Glu His Gln Gln Ala
                1605                1610                1615    
Thr Glu Leu Leu Arg Gln Ala His Met Arg Gln Met Glu Arg Gln Arg
            1620                1625                1630        
Glu Asp Gln Glu Gln Leu Gln Glu Glu Ile Lys Arg Leu Asn Arg Gln
        1635                1640                1645            
Leu Ala Gln Arg Ser Ser Ile Asp Asn Glu Asn Leu Val Ser Glu Arg
    1650                1655                1660                
Glu Arg Val Leu Leu Glu Glu Leu Glu Ala Leu Lys Gln Leu Ser Leu
1665                1670                1675                1680
Ala Gly Arg Glu Lys Leu Cys Cys Glu Leu Arg Asn Ser Ser Thr Gln
                1685                1690                1695    
Thr Gln Asn Gly Asn Glu Asn Gln Gly Glu Val Glu Glu Gln Thr Phe
            1700                1705                1710        
Lys Glu Lys Glu Leu Asp Arg Lys Pro Glu Asp Val Pro Pro Glu Ile
        1715                1720                1725            
Leu Ser Asn Glu Arg Tyr Ala Leu Gln Lys Ala Asn Asn Arg Leu Leu
    1730                1735                1740                
Lys Ile Leu Leu Glu Val Val Lys Thr Thr Ala Ala Val Glu Glu Thr
1745                1750                1755                1760
Ile Gly Arg His Val Leu Gly Ile Leu Asp Arg Ser Ser Lys Ser Gln
                1765                1770                1775    
Ser Ser Ala Ser Leu Ile Trp Arg Ser Glu Ala Glu Ala Ser Val Lys
            1780                1785                1790        
Ser Cys Val His Glu Glu His Thr Arg Val Thr Asp Glu Ser Ile Pro
        1795                1800                1805            
Ser Tyr Ser Gly Ser Asp Met Pro Arg Asn Asp Ile Asn Met Trp Ser
    1810                1815                1820                
Lys Val Thr Glu Glu Gly Thr Glu Leu Ser Gln Arg Leu Val Arg Ser
1825                1830                1835                1840
Gly Phe Ala Gly Thr Glu Ile Asp Pro Glu Asn Glu Glu Leu Met Leu
                1845                1850                1855    
Asn Ile Ser Ser Arg Leu Gln Ala Ala Val Glu Lys Leu Leu Glu Ala
            1860                1865                1870        
Ile Ser Glu Thr Ser Ser Gln Leu Glu His Ala Lys Val Thr Gln Thr
        1875                1880                1885            
Glu Leu Met Arg Glu Ser Phe Arg Gln Lys Gln Glu Ala Thr Glu Ser
    1890                1895                1900                
Leu Lys Cys Gln Glu Glu Leu Arg Glu Arg Leu His Glu Glu Ser Arg
1905                1910                1915                1920
Ala Arg Glu Gln Leu Ala Val Glu Leu Ser Lys Ala Glu Gly Val Ile
                1925                1930                1935    
Asp Gly Tyr Ala Asp Glu Lys Thr Leu Phe Glu Arg Gln Ile Gln Glu
            1940                1945                1950        
Lys Thr Asp Ile Ile Asp Arg Leu Glu Gln Glu Leu Leu Cys Ala Ser
        1955                1960                1965            
Asn Arg Leu Gln Glu Leu Glu Ala Glu Gln Gln Gln Ile Gln Glu Glu
    1970                1975                1980                
Arg Glu Leu Leu Ser Arg Gln Lys Glu Ala Met Lys Ala Glu Ala Gly
1985                1990                1995                2000
Pro Val Glu Gln Gln Leu Leu Gln Glu Thr Glu Lys Leu Met Lys Glu
                2005                2010                2015    
Lys Leu Glu Val Gln Cys Gln Ala Glu Lys Val Arg Asp Asp Leu Gln
            2020                2025                2030        
Lys Gln Val Lys Ala Leu Glu Ile Asp Val Glu Glu Gln Val Ser Arg
        2035                2040                2045            
Phe Ile Glu Leu Glu Gln Glu Lys Asn Thr Glu Leu Met Asp Leu Arg
    2050                2055                2060                
Gln Gln Asn Gln Ala Leu Glu Lys Gln Leu Glu Lys Met Arg Lys Phe
2065                2070                2075                2080
Leu Asp Glu Gln Ala Ile Asp Arg Glu His Glu Arg Asp Val Phe Gln
                2085                2090                2095    
Gln Glu Ile Gln Lys Leu Glu Gln Gln Leu Lys Val Val Pro Arg Phe
            2100                2105                2110        
Gln Pro Ile Ser Glu His Gln Thr Arg Glu Val Glu Gln Leu Ala Asn
        2115                2120                2125            
His Leu Lys Glu Lys Thr Asp Lys Cys Ser Glu Leu Leu Leu Ser Lys
    2130                2135                2140                
Glu Gln Leu Gln Arg Asp Ile Gln Glu Arg Asn Glu Glu Ile Glu Lys
2145                2150                2155                2160
Leu Glu Phe Arg Val Arg Glu Leu Glu Gln Ala Leu Leu Val Ser Ala
                2165                2170                2175    
Asp Thr Phe Gln Lys Val Glu Asp Arg Lys His Phe Gly Ala Val Glu
            2180                2185                2190        
Ala Lys Pro Glu Leu Ser Leu Glu Val Gln Leu Gln Ala Glu Arg Asp
        2195                2200                2205            
Ala Ile Asp Arg Lys Glu Lys Glu Ile Thr Asn Leu Glu Glu Gln Leu
    2210                2215                2220                
Glu Gln Phe Arg Glu Glu Leu Glu Asn Lys Asn Glu Glu Val Gln Gln
2225                2230                2235                2240
Leu His Met Gln Leu Glu Ile Gln Lys Lys Glu Ser Thr Thr Arg Leu
                2245                2250                2255    
Gln Glu Leu Glu Gln Glu Asn Lys Leu Phe Lys Asp Asp Met Glu Lys
            2260                2265                2270        
Leu Gly Leu Ala Ile Lys Glu Ser Asp Ala Met Ser Thr Gln Asp Gln
        2275                2280                2285            
His Val Leu Phe Gly Lys Phe Ala Gln Ile Ile Gln Glu Lys Glu Val
    2290                2295                2300                
Glu Ile Asp Gln Leu Asn Glu Gln Val Thr Lys Leu Gln Gln Gln Leu
2305                2310                2315                2320
Lys Ile Thr Thr Asp Asn Lys Val Ile Glu Glu Lys Asn Glu Leu Ile
                2325                2330                2335    
Arg Asp Leu Glu Thr Gln Ile Glu Cys Leu Met Ser Asp Gln Glu Cys
            2340                2345                2350        
Val Lys Arg Asn Arg Glu Glu Glu Ile Glu Gln Leu Asn Glu Val Ile
        2355                2360                2365            
Glu Lys Leu Gln Gln Glu Leu Ala Asn Ile Gly Gln Lys Thr Ser Met
    2370                2375                2380                
Asn Ala His Ser Leu Ser Glu Glu Ala Asp Ser Leu Lys His Gln Leu
2385                2390                2395                2400
Asp Val Val Ile Ala Glu Lys Leu Ala Leu Glu Gln Gln Val Glu Thr
                2405                2410                2415    
Ala Asn Glu Glu Met Thr Phe Met Lys Asn Val Leu Lys Glu Thr Asn
            2420                2425                2430        
Phe Lys Met Asn Gln Leu Thr Gln Glu Leu Phe Ser Leu Lys Arg Glu
        2435                2440                2445            
Arg Glu Ser Val Glu Lys Ile Gln Ser Ile Pro Glu Asn Ser Val Asn
    2450                2455                2460                
Val Ala Ile Asp His Leu Ser Lys Asp Lys Pro Glu Leu Glu Val Val
2465                2470                2475                2480
Leu Thr Glu Asp Ala Leu Lys Ser Leu Glu Asn Gln Thr Tyr Phe Lys
                2485                2490                2495    
Ser Phe Glu Glu Asn Gly Lys Gly Ser Ile Ile Asn Leu Glu Thr Arg
            2500                2505                2510        
Leu Leu Gln Leu Glu Ser Thr Val Ser Ala Lys Asp Leu Glu Leu Thr
        2515                2520                2525            
Gln Cys Tyr Lys Gln Ile Lys Asp Met Gln Glu Gln Gly Gln Phe Glu
    2530                2535                2540                
Thr Glu Met Leu Gln Lys Lys Ile Val Asn Leu Gln Lys Ile Val Glu
2545                2550                2555                2560
Glu Lys Val Ala Ala Ala Leu Val Ser Gln Ile Gln Leu Glu Ala Val
                2565                2570                2575    
Gln Glu Tyr Ala Lys Phe Cys Gln Asp Asn Gln Thr Ile Ser Ser Glu
            2580                2585                2590        
Pro Glu Arg Thr Asn Ile Gln Asn Leu Asn Gln Leu Arg Glu Asp Glu
        2595                2600                2605            
Leu Gly Ser Asp Ile Ser Ala Leu Thr Leu Arg Ile Ser Glu Leu Glu
    2610                2615                2620                
Ser Gln Val Val Glu Met His Thr Ser Leu Ile Leu Glu Lys Glu Gln
2625                2630                2635                2640
Val Glu Ile Ala Glu Lys Asn Val Leu Glu Lys Glu Lys Lys Leu Leu
                2645                2650                2655    
Glu Leu Gln Lys Leu Leu Glu Gly Asn Glu Lys Lys Gln Arg Glu Lys
            2660                2665                2670        
Glu Lys Lys Arg Ser Pro Gln Asp Val Glu Val Leu Lys Thr Thr Thr
        2675                2680                2685            
Glu Leu Phe His Ser Asn Glu Glu Ser Gly Phe Phe Asn Glu Leu Glu
    2690                2695                2700                
Ala Leu Arg Ala Glu Ser Val Ala Thr Lys Ala Glu Leu Ala Ser Tyr
2705                2710                2715                2720
Lys Glu Lys Ala Glu Lys Leu Gln Glu Glu Leu Leu Val Lys Glu Thr
                2725                2730                2735    
Asn Met Thr Ser Leu Gln Lys Asp Leu Ser Gln Val Arg Asp His Leu
            2740                2745                2750        
Ala Glu Ala Lys Glu Lys Leu Ser Ile Leu Glu Lys Glu Asp Glu Thr
        2755                2760                2765            
Glu Val Gln Glu Ser Lys Lys Ala Cys Met Phe Glu Pro Leu Pro Ile
    2770                2775                2780                
Lys Leu Ser Lys Ser Ile Ala Ser Gln Thr Asp Gly Thr Leu Lys Ile
2785                2790                2795                2800
Ser Ser Ser Asn Gln Thr Pro Gln Ile Leu Val Lys Asn Ala Gly Ile
                2805                2810                2815    
Gln Ile Asn Leu Gln Ser Glu Cys Ser Ser Glu Glu Val Thr Glu Ile
            2820                2825                2830        
Ile Ser Gln Phe Thr Glu Lys Ile Glu Lys Met Gln Glu Leu His Ala
        2835                2840                2845            
Ala Glu Ile Leu Asp Met Glu Ser Arg His Ile Ser Glu Thr Glu Thr
    2850                2855                2860                
Leu Lys Arg Glu His Tyr Val Ala Val Gln Leu Leu Lys Glu Glu Cys
2865                2870                2875                2880
Gly Thr Leu Lys Ala Val Ile Gln Cys Leu Arg Ser Lys Glu Val Phe
                2885                2890                2895    
Gly Phe Tyr Asn Met Cys Phe Ser Thr Leu Cys Asp Ser Gly Ser Asp
            2900                2905                2910        
Trp Gly Gln Gly Ile Tyr Leu Thr His Ser Gln Gly Phe Asp Ile Ala
        2915                2920                2925            
Ser Glu Gly Arg Gly Glu Glu Ser Glu Ser Ala Thr Asp Ser Phe Pro
    2930                2935                2940                
Lys Lys Ile Lys Gly Leu Leu Arg Ala Val His Asn Glu Gly Met Gln
2945                2950                2955                2960
Val Leu Ser Leu Thr Glu Ser Pro Tyr Ser Asp Gly Glu Asp His Ser
                2965                2970                2975    
Ile Gln Gln Val Ser Glu Pro Trp Leu Glu Glu Arg Lys Ala Tyr Ile
            2980                2985                2990        
Asn Thr Ile Ser Ser Leu Lys Asp Leu Ile Thr Lys Met Gln Leu Gln
        2995                3000                3005            
Arg Glu Ala Glu Val Tyr Asp Ser Ser Gln Ser His Glu Ser Phe Ser
    3010                3015                3020                
Asp Trp Arg Gly Glu Leu Leu Leu Ala Leu Gln Gln Val Phe Leu Glu
3025                3030                3035                3040
Glu Arg Ser Val Leu Leu Ala Ala Phe Arg Thr Glu Leu Thr Ala Leu
                3045                3050                3055    
Gly Thr Thr Asp Ala Val Gly Leu Leu Asn Cys Leu Glu Gln Arg Ile
            3060                3065                3070        
Gln Glu Gln Gly Val Glu Tyr Gln Ala Ala Met Glu Cys Leu Gln Lys
        3075                3080                3085            
Ala Asp Arg Arg Ser Leu Leu Ser Glu Ile Gln Ala Leu His Ala Gln
    3090                3095                3100                
Met Asn Gly Arg Lys Ile Thr Leu Lys Arg Glu Gln Glu Ser Glu Lys
3105                3110                3115                3120
Pro Ser Gln Glu Leu Leu Glu Tyr Asn Ile Gln Gln Lys Gln Ser Gln
                3125                3130                3135    
Met Leu Glu Met Gln Val Glu Leu Ser Ser Met Lys Asp Arg Ala Thr
            3140                3145                3150        
Glu Leu Gln Glu Gln Leu Ser Ser Glu Lys Met Val Val Ala Glu Leu
        3155                3160                3165            
Lys Ser Glu Leu Ala Gln Thr Lys Leu Glu Leu Glu Thr Thr Leu Lys
    3170                3175                3180                
Ala Gln His Lys His Leu Lys Glu Leu Glu Ala Phe Arg Leu Glu Val
3185                3190                3195                3200
Lys Asp Lys Thr Asp Glu Val His Leu Leu Asn Asp Thr Leu Ala Ser
                3205                3210                3215    
Glu Gln Lys Lys Ser Arg Glu Leu Gln Trp Ala Leu Glu Lys Glu Lys
            3220                3225                3230        
Ala Lys Leu Gly Arg Ser Glu Glu Arg Asp Lys Glu Glu Leu Glu Asp
        3235                3240                3245            
Leu Lys Phe Ser Leu Glu Ser Gln Lys Gln Arg Asn Leu Gln Leu Asn
    3250                3255                3260                
Leu Leu Leu Glu Gln Gln Lys Gln Leu Leu Asn Glu Ser Gln Gln Lys
3265                3270                3275                3280
Ile Glu Ser Gln Arg Met Leu Tyr Asp Ala Gln Leu Ser Glu Glu Gln
                3285                3290                3295    
Gly Arg Asn Leu Glu Leu Gln Val Leu Leu Glu Ser Glu Lys Val Arg
            3300                3305                3310        
Ile Arg Glu Met Ser Ser Thr Leu Asp Arg Glu Arg Glu Leu His Ala
        3315                3320                3325            
Gln Leu Gln Ser Ser Asp Gly Thr Gly Gln Ser Arg Pro Pro Leu Pro
    3330                3335                3340                
Ser Glu Asp Leu Leu Lys Glu Leu Gln Lys Gln Leu Glu Glu Lys His
3345                3350                3355                3360
Ser Arg Ile Val Glu Leu Leu Asn Glu Thr Glu Lys Tyr Lys Leu Asp
                3365                3370                3375    
Ser Leu Gln Thr Arg Gln Gln Met Glu Lys Asp Arg Gln Val His Arg
            3380                3385                3390        
Lys Thr Leu Gln Thr Glu Gln Glu Ala Asn Thr Glu Gly Gln Lys Lys
        3395                3400                3405            
Met His Glu Leu Gln Ser Lys Val Glu Asp Leu Gln Arg Gln Leu Glu
    3410                3415                3420                
Glu Lys Arg Gln Gln Val Tyr Lys Leu Asp Leu Glu Gly Gln Arg Leu
3425                3430                3435                3440
Gln Gly Ile Met Gln Glu Phe Gln Lys Gln Glu Leu Glu Arg Glu Glu
                3445                3450                3455    
Lys Arg Glu Ser Arg Arg Ile Leu Tyr Gln Asn Leu Asn Glu Pro Thr
            3460                3465                3470        
Thr Trp Ser Leu Thr Ser Asp Arg Thr Arg Asn Trp Val Leu Gln Gln
        3475                3480                3485            
Lys Ile Glu Gly Glu Thr Lys Glu Ser Asn Tyr Ala Lys Leu Ile Glu
    3490                3495                3500                
Met Asn Gly Gly Gly Thr Gly Cys Asn His Glu Leu Glu Met Ile Arg
3505                3510                3515                3520
Gln Lys Leu Gln Cys Val Ala Ser Lys Leu Gln Val Leu Pro Gln Lys
                3525                3530                3535    
Ala Ser Glu Arg Leu Gln Phe Glu Thr Ala Asp Asp Glu Asp Phe Ile
            3540                3545                3550        
Trp Val Gln Glu Asn Ile Asp Glu Ile Ile Leu Gln Leu Gln Lys Leu
        3555                3560                3565            
Thr Gly Gln Gln Gly Glu Glu Pro Ser Leu Val Ser Pro Ser Thr Ser
    3570                3575                3580                
Cys Gly Ser Leu Thr Glu Arg Leu Leu Arg Gln Asn Ala Glu Leu Thr
3585                3590                3595                3600
Gly His Ile Ser Gln Leu Thr Glu Glu Lys Asn Asp Leu Arg Asn Met
                3605                3610                3615    
Val Met Lys Leu Glu Glu Gln Ile Arg Trp Tyr Arg Gln Thr Gly Ala
            3620                3625                3630        
Gly Arg Asp Asn Ser Ser Arg Phe Ser Leu Asn Gly Gly Ala Asn Ile
        3635                3640                3645            
Glu Ala Ile Ile Ala Ser Glu Lys Glu Val Trp Asn Arg Glu Lys Leu
    3650                3655                3660                
Thr Leu Gln Lys Ser Leu Lys Arg Ala Glu Ala Glu Val Tyr Lys Leu
3665                3670                3675                3680
Lys Ala Glu Leu Arg Asn Asp Ser Leu Leu Gln Thr Leu Ser Pro Asp
                3685                3690                3695    
Ser Glu His Val Thr Leu Lys Arg Ile Tyr Gly Lys Tyr Leu Arg Ala
            3700                3705                3710        
Glu Ser Phe Arg Lys Ala Leu Ile Tyr Gln Lys Lys Tyr Leu Leu Leu
        3715                3720                3725            
Leu Leu Gly Gly Phe Gln Glu Cys Glu Asp Ala Thr Leu Ala Leu Leu
    3730                3735                3740                
Ala Arg Met Gly Gly Gln Pro Ala Phe Thr Asp Leu Glu Val Ile Thr
3745                3750                3755                3760
Asn Arg Pro Lys Gly Phe Thr Arg Phe Arg Ser Ala Val Arg Val Ser
                3765                3770                3775    
Ile Ala Ile Ser Arg Met Lys Phe Leu Val Arg Arg Trp His Arg Val
            3780                3785                3790        
Thr Gly Ser Val Ser Ile Asn Ile Asn Arg Asp Gly Phe Gly Leu Asn
        3795                3800                3805            
Gln Gly Ala Glu Lys Thr Asp Ser Phe Tyr His Ser Ser Gly Gly Leu
    3810                3815                3820                
Glu Leu Tyr Gly Glu Pro Arg His Thr Thr Tyr Arg Ser Arg Ser Asp
3825                3830                3835                3840
Leu Asp Tyr Ile Arg Ser Pro Leu Pro Phe Gln Asn Arg Tyr Pro Gly
                3845                3850                3855    
Thr Pro Ala Asp Phe Asn Pro Gly Ser Leu Ala Cys Ser Gln Leu Gln
            3860                3865                3870        
Asn Tyr Asp Pro Asp Arg Ala Leu Thr Asp Tyr Ile Thr Arg Leu Glu
        3875                3880                3885            
Ala Leu Gln Arg Arg Leu Gly Thr Ile Gln Ser Gly Ser Thr Thr Gln
    3890                3895                3900                
Phe His Ala Gly Met Arg Arg
3905                3910    


<210> 8272
<211> 3929
<212> PRT
<213> Homo sapiens

<400> 8272
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys
 1               5                  10                  15      
Ile Glu Glu Leu Ser Leu Ala Phe Leu Val Arg Gln Leu Ala Gln Phe
            20                  25                  30          
Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln
        35                  40                  45              
Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp Val Ser Ala His
    50                  55                  60                  
His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn
65                  70                  75                  80  
Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu Ser Thr Ile Met
                85                  90                  95      
Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu Gln Gly Phe Ser
            100                 105                 110         
Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp Asp Cys Ser Ser
        115                 120                 125             
Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly Lys Pro Thr Asn
    130                 135                 140                 
Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln
145                 150                 155                 160 
Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met Glu Ser Glu Leu
                165                 170                 175     
Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu
            180                 185                 190         
Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln Leu Gln Glu Phe
        195                 200                 205             
Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr Gln Leu Thr Ala
    210                 215                 220                 
Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr Met Arg Glu Phe
225                 230                 235                 240 
Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln
                245                 250                 255     
Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His Ser Ser Thr Ala
            260                 265                 270         
Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr His Gln Gln Gln
        275                 280                 285             
Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu
    290                 295                 300                 
Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr
305                 310                 315                 320 
Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile
                325                 330                 335     
Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr Lys Ile Ile Glu
            340                 345                 350         
Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu Thr Thr Ala Asp
        355                 360                 365             
Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu
    370                 375                 380                 
Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys Gln Lys Glu Arg
385                 390                 395                 400 
Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr Val Glu Glu Leu
                405                 410                 415     
Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr Asp Ile Val Gln
            420                 425                 430         
Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu
        435                 440                 445             
Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu
    450                 455                 460                 
Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys Thr Arg His Lys
465                 470                 475                 480 
Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn Ile Thr Val Asn
                485                 490                 495     
Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile
            500                 505                 510         
Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu
        515                 520                 525             
Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp
    530                 535                 540                 
Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg
545                 550                 555                 560 
Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser
                565                 570                 575     
Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu
            580                 585                 590         
Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu Val Thr Asn Tyr
        595                 600                 605             
Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp
    610                 615                 620                 
Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Thr Gln
625                 630                 635                 640 
Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu
                645                 650                 655     
Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly
            660                 665                 670         
Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln
        675                 680                 685             
Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu Ile Thr Lys Gln
    690                 695                 700                 
Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser
705                 710                 715                 720 
Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln Ile Asn Glu Leu
                725                 730                 735     
Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Thr
            740                 745                 750         
Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr Glu Leu Leu Glu
        755                 760                 765             
Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln
    770                 775                 780                 
Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys Lys Thr Leu Glu
785                 790                 795                 800 
Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu Glu Arg Leu Ile
                805                 810                 815     
Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys
            820                 825                 830         
Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys
        835                 840                 845             
Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn Thr Phe Ser Phe
    850                 855                 860                 
Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr
865                 870                 875                 880 
Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys
                885                 890                 895     
Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu
            900                 905                 910         
His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met Lys Ser Ser Val
        915                 920                 925             
Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu Glu Met Gly Glu
    930                 935                 940                 
Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys Leu Glu Val Thr
945                 950                 955                 960 
Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu
                965                 970                 975     
Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val
            980                 985                 990         
Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu Arg Cys Arg Glu
        995                 1000                1005            
Leu Glu Ile Ile Ile Asn His Asn Arg Ala Glu Asn Val Gln Ser Cys
    1010                1015                1020                
Asp Thr Gln Val Ser Ser Leu Leu Asp Gly Val Val Thr Met Thr Ser
1025                1030                1035                1040
Arg Gly Ala Glu Gly Ser Val Ser Lys Val Asn Lys Ser Phe Gly Glu
                1045                1050                1055    
Glu Ser Lys Ile Met Val Glu Asp Lys Val Ser Phe Glu Asn Met Thr
            1060                1065                1070        
Val Gly Glu Glu Ser Lys Gln Glu Gln Leu Ile Leu Asp His Leu Pro
        1075                1080                1085            
Ser Val Thr Lys Glu Ser Ser Leu Arg Ala Thr Gln Pro Ser Glu Asn
    1090                1095                1100                
Asp Lys Leu Gln Lys Glu Leu Asn Val Leu Lys Ser Glu Gln Asn Asp
1105                1110                1115                1120
Leu Arg Leu Gln Met Glu Ala Gln Arg Ile Cys Leu Ser Leu Val Tyr
                1125                1130                1135    
Ser Thr His Val Asp Gln Val Arg Glu Tyr Met Glu Asn Glu Lys Asp
            1140                1145                1150        
Lys Ala Leu Cys Ser Leu Lys Glu Glu Leu Ile Phe Ala Gln Glu Glu
        1155                1160                1165            
Lys Ile Lys Glu Leu Gln Lys Ile His Gln Leu Glu Leu Gln Thr Met
    1170                1175                1180                
Lys Thr Gln Glu Thr Gly Asp Glu Gly Lys Pro Leu His Leu Leu Ile
1185                1190                1195                1200
Gly Lys Leu Gln Lys Ala Val Ser Glu Glu Cys Ser Tyr Phe Leu Gln
                1205                1210                1215    
Thr Leu Cys Ser Val Leu Gly Glu Tyr Tyr Thr Pro Ala Leu Lys Cys
            1220                1225                1230        
Glu Val Asn Ala Glu Asp Lys Glu Asn Ser Gly Asp Tyr Ile Ser Glu
        1235                1240                1245            
Asn Glu Asp Pro Glu Leu Gln Asp Tyr Arg Tyr Glu Val Gln Asp Phe
    1250                1255                1260                
Gln Glu Asn Met His Thr Leu Leu Asn Lys Val Thr Glu Glu Tyr Asn
1265                1270                1275                1280
Lys Leu Leu Val Leu Gln Thr Arg Leu Ser Lys Ile Trp Gly Gln Gln
                1285                1290                1295    
Thr Asp Gly Met Lys Leu Glu Phe Gly Glu Glu Asn Leu Pro Lys Glu
            1300                1305                1310        
Glu Thr Glu Phe Leu Ser Ile His Ser Gln Met Thr Asn Leu Glu Asp
        1315                1320                1325            
Ile Asp Val Asn His Lys Ser Lys Leu Ser Ser Leu Gln Asp Leu Glu
    1330                1335                1340                
Lys Thr Lys Leu Glu Glu Gln Val Gln Glu Leu Glu Ser Leu Ile Ser
1345                1350                1355                1360
Ser Leu Gln Gln Gln Leu Lys Glu Thr Glu Gln Asn Tyr Glu Ala Glu
                1365                1370                1375    
Ile His Cys Leu Gln Lys Arg Leu Gln Ala Val Ser Glu Ser Thr Val
            1380                1385                1390        
Pro Pro Ser Leu Pro Val Asp Ser Val Val Ile Thr Glu Ser Asp Ala
        1395                1400                1405            
Gln Arg Thr Met Tyr Pro Gly Ser Cys Val Lys Lys Asn Ile Asp Gly
    1410                1415                1420                
Thr Ile Glu Phe Ser Gly Glu Phe Gly Val Lys Glu Glu Thr Asn Ile
1425                1430                1435                1440
Val Lys Leu Leu Glu Lys Gln Tyr Gln Glu Gln Leu Glu Glu Glu Val
                1445                1450                1455    
Ala Lys Val Ile Val Ser Met Ser Ile Ala Phe Ala Gln Gln Thr Glu
            1460                1465                1470        
Leu Ser Arg Ile Ser Gly Gly Lys Glu Asn Thr Ala Ser Ser Lys Gln
        1475                1480                1485            
Ala His Ala Val Cys Gln Gln Glu Gln His Tyr Phe Asn Glu Met Lys
    1490                1495                1500                
Leu Ser Gln Asp Gln Ile Gly Phe Gln Thr Phe Glu Thr Val Asp Val
1505                1510                1515                1520
Lys Phe Lys Glu Glu Phe Lys Pro Leu Ser Lys Glu Leu Gly Glu His
                1525                1530                1535    
Gly Lys Glu Ile Leu Leu Ser Asn Ser Asp Pro His Asp Ile Pro Glu
            1540                1545                1550        
Ser Lys Asp Cys Val Leu Thr Ile Ser Glu Glu Met Phe Ser Lys Asp
        1555                1560                1565            
Lys Thr Phe Ile Val Arg Gln Ser Ile His Asp Glu Ile Ser Val Ser
    1570                1575                1580                
Ser Met Asp Ala Ser Arg Gln Leu Met Leu Asn Glu Glu Gln Leu Glu
1585                1590                1595                1600
Asp Met Arg Gln Glu Leu Val Arg Gln Tyr Gln Glu His Gln Gln Ala
                1605                1610                1615    
Thr Glu Leu Leu Arg Gln Ala His Met Arg Gln Met Glu Arg Gln Arg
            1620                1625                1630        
Glu Asp Gln Glu Gln Leu Gln Glu Glu Ile Lys Arg Leu Asn Arg Gln
        1635                1640                1645            
Leu Ala Gln Arg Ser Ser Ile Asp Asn Glu Asn Leu Val Ser Glu Arg
    1650                1655                1660                
Glu Arg Val Leu Leu Glu Glu Leu Glu Ala Leu Lys Gln Leu Ser Leu
1665                1670                1675                1680
Ala Gly Arg Glu Lys Leu Cys Cys Glu Leu Arg Asn Ser Ser Thr Gln
                1685                1690                1695    
Thr Gln Asn Gly Asn Glu Asn Gln Gly Glu Val Glu Glu Gln Thr Phe
            1700                1705                1710        
Lys Glu Lys Glu Leu Asp Arg Lys Pro Glu Asp Val Pro Pro Glu Ile
        1715                1720                1725            
Leu Ser Asn Glu Arg Tyr Ala Leu Gln Lys Ala Asn Asn Arg Leu Leu
    1730                1735                1740                
Lys Ile Leu Leu Glu Val Val Lys Thr Thr Ala Ala Val Glu Glu Thr
1745                1750                1755                1760
Ile Gly Arg His Val Leu Gly Ile Leu Asp Arg Ser Ser Lys Ser Gln
                1765                1770                1775    
Ser Ser Ala Ser Leu Ile Trp Arg Ser Glu Ala Glu Ala Ser Val Lys
            1780                1785                1790        
Ser Cys Val His Glu Glu His Thr Arg Val Thr Asp Glu Ser Ile Pro
        1795                1800                1805            
Ser Tyr Ser Gly Ser Asp Met Pro Arg Asn Asp Ile Asn Met Trp Ser
    1810                1815                1820                
Lys Val Thr Glu Glu Gly Thr Glu Leu Ser Gln Arg Leu Val Arg Ser
1825                1830                1835                1840
Gly Phe Ala Gly Thr Glu Ile Asp Pro Glu Asn Glu Glu Leu Met Leu
                1845                1850                1855    
Asn Ile Ser Ser Arg Leu Gln Ala Ala Val Glu Lys Leu Leu Glu Ala
            1860                1865                1870        
Ile Ser Glu Thr Ser Ser Gln Leu Glu His Ala Lys Val Thr Gln Thr
        1875                1880                1885            
Glu Leu Met Arg Glu Ser Phe Arg Gln Lys Gln Glu Ala Thr Glu Ser
    1890                1895                1900                
Leu Lys Cys Gln Glu Glu Leu Arg Glu Arg Leu His Glu Glu Ser Arg
1905                1910                1915                1920
Ala Arg Glu Gln Leu Ala Val Glu Leu Ser Lys Ala Glu Gly Val Ile
                1925                1930                1935    
Asp Gly Tyr Ala Asp Glu Lys Thr Leu Phe Glu Arg Gln Ile Gln Glu
            1940                1945                1950        
Lys Thr Asp Ile Ile Asp Arg Leu Glu Gln Glu Leu Leu Cys Ala Ser
        1955                1960                1965            
Asn Arg Leu Gln Glu Leu Glu Ala Glu Gln Gln Gln Ile Gln Glu Glu
    1970                1975                1980                
Arg Glu Leu Leu Ser Arg Gln Lys Glu Ala Met Lys Ala Glu Ala Gly
1985                1990                1995                2000
Pro Val Glu Gln Gln Leu Leu Gln Glu Thr Glu Lys Leu Met Lys Glu
                2005                2010                2015    
Lys Leu Glu Val Gln Cys Gln Ala Glu Lys Val Arg Asp Asp Leu Gln
            2020                2025                2030        
Lys Gln Val Lys Ala Leu Glu Ile Asp Val Glu Glu Gln Val Ser Arg
        2035                2040                2045            
Phe Ile Glu Leu Glu Gln Glu Lys Asn Thr Glu Leu Met Asp Leu Arg
    2050                2055                2060                
Gln Gln Asn Gln Ala Leu Glu Lys Gln Leu Glu Lys Met Arg Lys Phe
2065                2070                2075                2080
Leu Asp Glu Gln Ala Ile Asp Arg Glu His Glu Arg Asp Val Phe Gln
                2085                2090                2095    
Gln Glu Ile Gln Lys Leu Glu Gln Gln Leu Lys Val Val Pro Arg Phe
            2100                2105                2110        
Gln Pro Ile Ser Glu His Gln Thr Arg Glu Val Glu Gln Leu Ala Asn
        2115                2120                2125            
His Leu Lys Glu Lys Thr Asp Lys Cys Ser Glu Leu Leu Leu Ser Lys
    2130                2135                2140                
Glu Gln Leu Gln Arg Asp Ile Gln Glu Arg Asn Glu Glu Ile Glu Lys
2145                2150                2155                2160
Leu Glu Phe Arg Val Arg Glu Leu Glu Gln Ala Leu Leu Val Gln Asp
                2165                2170                2175    
Arg Lys His Phe Gly Ala Val Glu Ala Lys Pro Glu Leu Ser Leu Glu
            2180                2185                2190        
Val Gln Leu Gln Ala Glu Arg Asp Ala Ile Asp Arg Lys Glu Lys Glu
        2195                2200                2205            
Ile Thr Asn Leu Glu Glu Gln Leu Glu Gln Phe Arg Glu Glu Leu Glu
    2210                2215                2220                
Asn Lys Asn Glu Glu Val Gln Gln Leu His Met Gln Leu Glu Ile Gln
2225                2230                2235                2240
Lys Lys Glu Ser Thr Thr Arg Leu Gln Glu Leu Glu Gln Glu Asn Lys
                2245                2250                2255    
Leu Phe Lys Asp Asp Met Glu Lys Leu Gly Leu Ala Ile Lys Glu Ser
            2260                2265                2270        
Asp Ala Met Ser Thr Gln Asp Gln His Val Leu Phe Gly Lys Phe Ala
        2275                2280                2285            
Gln Ile Ile Gln Glu Lys Glu Val Glu Ile Asp Gln Leu Asn Glu Gln
    2290                2295                2300                
Val Thr Lys Leu Gln Gln Gln Leu Lys Ile Thr Thr Asp Asn Lys Val
2305                2310                2315                2320
Ile Glu Glu Lys Asn Glu Leu Ile Arg Asp Leu Glu Thr Gln Ile Glu
                2325                2330                2335    
Cys Leu Met Ser Asp Gln Glu Cys Val Lys Arg Asn Arg Glu Glu Glu
            2340                2345                2350        
Ile Glu Gln Leu Asn Glu Val Ile Glu Lys Leu Gln Gln Glu Leu Ala
        2355                2360                2365            
Asn Ile Gly Gln Lys Thr Ser Met Asn Ala His Ser Leu Ser Glu Glu
    2370                2375                2380                
Ala Asp Ser Leu Lys His Gln Leu Asp Val Val Ile Ala Glu Lys Leu
2385                2390                2395                2400
Ala Leu Glu Gln Gln Val Glu Thr Ala Asn Glu Glu Met Thr Phe Met
                2405                2410                2415    
Lys Asn Val Leu Lys Glu Thr Asn Phe Lys Met Asn Gln Leu Thr Gln
            2420                2425                2430        
Glu Leu Phe Ser Leu Lys Arg Glu Arg Glu Ser Val Glu Lys Ile Gln
        2435                2440                2445            
Ser Ile Pro Glu Asn Ser Val Asn Val Ala Ile Asp His Leu Ser Lys
    2450                2455                2460                
Asp Lys Pro Glu Leu Glu Val Val Leu Thr Glu Asp Ala Leu Lys Ser
2465                2470                2475                2480
Leu Glu Asn Gln Thr Tyr Phe Lys Ser Phe Glu Glu Asn Gly Lys Gly
                2485                2490                2495    
Ser Ile Ile Asn Leu Glu Thr Arg Leu Leu Gln Leu Glu Ser Thr Val
            2500                2505                2510        
Ser Ala Lys Asp Leu Glu Leu Thr Gln Cys Tyr Lys Gln Ile Lys Asp
        2515                2520                2525            
Met Gln Glu Gln Gly Gln Phe Glu Thr Glu Met Leu Gln Lys Lys Ile
    2530                2535                2540                
Val Asn Leu Gln Lys Ile Val Glu Glu Lys Val Ala Ala Ala Leu Val
2545                2550                2555                2560
Ser Gln Ile Gln Leu Glu Ala Val Gln Glu Tyr Ala Lys Phe Cys Gln
                2565                2570                2575    
Asp Asn Gln Thr Ile Ser Ser Glu Pro Glu Arg Thr Asn Ile Gln Asn
            2580                2585                2590        
Leu Asn Gln Leu Arg Glu Asp Glu Leu Gly Ser Asp Ile Ser Ala Leu
        2595                2600                2605            
Thr Leu Arg Ile Ser Glu Leu Glu Ser Gln Val Val Glu Met His Thr
    2610                2615                2620                
Ser Leu Ile Leu Glu Lys Glu Gln Val Glu Ile Ala Glu Lys Asn Val
2625                2630                2635                2640
Leu Glu Lys Glu Lys Lys Leu Leu Glu Leu Gln Lys Leu Leu Glu Gly
                2645                2650                2655    
Asn Glu Lys Lys Gln Arg Glu Lys Glu Lys Lys Arg Ser Pro Gln Asp
            2660                2665                2670        
Val Glu Val Leu Lys Thr Thr Thr Glu Leu Phe His Ser Asn Glu Glu
        2675                2680                2685            
Ser Gly Phe Phe Asn Glu Leu Glu Ala Leu Arg Ala Glu Ser Val Ala
    2690                2695                2700                
Thr Lys Ala Glu Leu Ala Ser Tyr Lys Glu Lys Ala Glu Lys Leu Gln
2705                2710                2715                2720
Glu Glu Leu Leu Val Lys Glu Thr Asn Met Thr Ser Leu Gln Lys Asp
                2725                2730                2735    
Leu Ser Gln Val Arg Asp His Leu Ala Glu Ala Lys Glu Lys Leu Ser
            2740                2745                2750        
Ile Leu Glu Lys Glu Asp Glu Thr Glu Val Gln Glu Ser Lys Lys Ala
        2755                2760                2765            
Cys Met Phe Glu Pro Leu Pro Ile Lys Leu Ser Lys Ser Ile Ala Ser
    2770                2775                2780                
Gln Thr Asp Gly Thr Leu Lys Ile Ser Ser Ser Asn Gln Thr Pro Gln
2785                2790                2795                2800
Ile Leu Val Lys Asn Ala Gly Ile Gln Ile Asn Leu Gln Ser Glu Cys
                2805                2810                2815    
Ser Ser Glu Glu Val Thr Glu Ile Ile Ser Gln Phe Thr Glu Lys Ile
            2820                2825                2830        
Glu Lys Met Gln Glu Leu His Ala Ala Glu Ile Leu Asp Met Glu Ser
        2835                2840                2845            
Arg His Ile Ser Glu Thr Glu Thr Leu Lys Arg Glu His Tyr Val Ala
    2850                2855                2860                
Val Gln Leu Leu Lys Glu Glu Cys Gly Thr Leu Lys Ala Val Ile Gln
2865                2870                2875                2880
Cys Leu Arg Ser Lys Glu Gly Ser Ser Ile Pro Glu Leu Ala His Ser
                2885                2890                2895    
Asp Ala Tyr Gln Thr Arg Glu Ile Cys Ser Ser Asp Ser Gly Ser Asp
            2900                2905                2910        
Trp Gly Gln Gly Ile Tyr Leu Thr His Ser Gln Gly Phe Asp Ile Ala
        2915                2920                2925            
Ser Glu Gly Arg Gly Glu Glu Ser Glu Ser Ala Thr Asp Ser Phe Pro
    2930                2935                2940                
Lys Lys Ile Lys Gly Leu Leu Arg Ala Val His Asn Glu Gly Met Gln
2945                2950                2955                2960
Val Leu Ser Leu Thr Glu Ser Pro Tyr Ser Asp Gly Glu Asp His Ser
                2965                2970                2975    
Ile Gln Gln Val Ser Glu Pro Trp Leu Glu Glu Arg Lys Ala Tyr Ile
            2980                2985                2990        
Asn Thr Ile Ser Ser Leu Lys Asp Leu Ile Thr Lys Met Gln Leu Gln
        2995                3000                3005            
Arg Glu Ala Glu Val Tyr Asp Ser Ser Gln Ser His Glu Ser Phe Ser
    3010                3015                3020                
Asp Trp Arg Gly Glu Leu Leu Leu Ala Leu Gln Gln Val Phe Leu Glu
3025                3030                3035                3040
Glu Arg Ser Val Leu Leu Ala Ala Phe Arg Thr Glu Leu Thr Ala Leu
                3045                3050                3055    
Gly Thr Thr Asp Ala Val Gly Leu Leu Asn Cys Leu Glu Gln Arg Ile
            3060                3065                3070        
Gln Glu Gln Gly Val Glu Tyr Gln Ala Ala Met Glu Cys Leu Gln Lys
        3075                3080                3085            
Ala Asp Arg Arg Ser Leu Leu Ser Glu Ile Gln Ala Leu His Ala Gln
    3090                3095                3100                
Met Asn Gly Arg Lys Ile Thr Leu Lys Arg Glu Gln Glu Ser Glu Lys
3105                3110                3115                3120
Pro Ser Gln Glu Leu Leu Glu Tyr Asn Ile Gln Gln Lys Gln Ser Gln
                3125                3130                3135    
Met Leu Glu Met Gln Val Glu Leu Ser Ser Met Lys Asp Arg Ala Thr
            3140                3145                3150        
Glu Leu Gln Glu Gln Leu Ser Ser Glu Lys Met Val Val Ala Glu Leu
        3155                3160                3165            
Lys Ser Glu Leu Ala Gln Thr Lys Leu Glu Leu Glu Thr Thr Leu Lys
    3170                3175                3180                
Ala Gln His Lys His Leu Lys Glu Leu Glu Ala Phe Arg Leu Glu Val
3185                3190                3195                3200
Lys Asp Lys Thr Asp Glu Val His Leu Leu Asn Asp Thr Leu Ala Ser
                3205                3210                3215    
Glu Gln Lys Lys Ser Arg Glu Leu Gln Trp Ala Leu Glu Lys Glu Lys
            3220                3225                3230        
Ala Lys Leu Gly Arg Ser Glu Glu Arg Asp Lys Glu Glu Leu Glu Asp
        3235                3240                3245            
Leu Lys Phe Ser Leu Glu Ser Gln Lys Gln Arg Asn Leu Gln Leu Asn
    3250                3255                3260                
Leu Leu Leu Glu Gln Gln Lys Gln Leu Leu Asn Glu Ser Gln Gln Lys
3265                3270                3275                3280
Ile Glu Ser Gln Arg Met Leu Tyr Asp Ala Gln Leu Ser Glu Glu Gln
                3285                3290                3295    
Gly Arg Asn Leu Glu Leu Gln Val Leu Leu Glu Ser Glu Lys Val Arg
            3300                3305                3310        
Ile Arg Glu Met Ser Ser Thr Leu Asp Arg Glu Arg Glu Leu His Ala
        3315                3320                3325            
Gln Leu Gln Ser Ser Asp Gly Thr Gly Gln Ser Arg Pro Pro Leu Pro
    3330                3335                3340                
Ser Glu Asp Leu Leu Lys Glu Leu Gln Lys Gln Leu Glu Glu Lys His
3345                3350                3355                3360
Ser Arg Ile Val Glu Leu Leu Asn Glu Thr Glu Lys Tyr Lys Leu Asp
                3365                3370                3375    
Ser Leu Gln Thr Arg Gln Gln Met Glu Lys Asp Arg Gln Val His Arg
            3380                3385                3390        
Lys Thr Leu Gln Thr Glu Gln Glu Ala Asn Thr Glu Gly Gln Lys Lys
        3395                3400                3405            
Met His Glu Leu Gln Ser Lys Val Glu Asp Leu Gln Arg Gln Leu Glu
    3410                3415                3420                
Glu Lys Arg Gln Gln Val Tyr Lys Leu Asp Leu Glu Gly Gln Arg Leu
3425                3430                3435                3440
Gln Gly Ile Met Gln Glu Phe Gln Lys Gln Glu Leu Glu Arg Glu Glu
                3445                3450                3455    
Lys Arg Glu Ser Arg Arg Ile Leu Tyr Gln Asn Leu Asn Glu Pro Thr
            3460                3465                3470        
Thr Trp Ser Leu Thr Ser Asp Arg Thr Arg Asn Trp Val Leu Gln Gln
        3475                3480                3485            
Lys Ile Glu Gly Glu Thr Lys Glu Ser Asn Tyr Ala Lys Leu Ile Glu
    3490                3495                3500                
Met Asn Gly Gly Gly Thr Gly Cys Asn His Glu Leu Glu Met Ile Arg
3505                3510                3515                3520
Gln Lys Leu Gln Cys Val Ala Ser Lys Leu Gln Val Leu Pro Gln Lys
                3525                3530                3535    
Ala Ser Glu Arg Leu Gln Phe Glu Thr Ala Asp Asp Glu Asp Phe Ile
            3540                3545                3550        
Trp Val Gln Glu Asn Ile Asp Glu Ile Ile Leu Gln Leu Gln Lys Leu
        3555                3560                3565            
Thr Gly Gln Gln Gly Glu Glu Pro Ser Leu Val Ser Pro Ser Thr Ser
    3570                3575                3580                
Cys Gly Ser Leu Thr Glu Arg Leu Leu Arg Gln Asn Ala Glu Leu Thr
3585                3590                3595                3600
Gly His Ile Ser Gln Leu Thr Glu Glu Lys Asn Asp Leu Arg Asn Met
                3605                3610                3615    
Val Met Lys Leu Glu Glu Gln Ile Arg Trp Tyr Arg Gln Thr Gly Ala
            3620                3625                3630        
Gly Arg Asp Asn Ser Ser Arg Phe Ser Leu Asn Gly Gly Ala Asn Ile
        3635                3640                3645            
Glu Ala Ile Ile Ala Ser Glu Lys Glu Val Trp Asn Arg Glu Lys Leu
    3650                3655                3660                
Thr Leu Gln Lys Ser Leu Lys Arg Ala Glu Ala Glu Val Tyr Lys Leu
3665                3670                3675                3680
Lys Ala Glu Leu Arg Asn Asp Ser Leu Leu Gln Thr Leu Ser Pro Asp
                3685                3690                3695    
Ser Glu His Val Thr Leu Lys Arg Ile Tyr Gly Lys Tyr Leu Arg Ala
            3700                3705                3710        
Glu Ser Phe Arg Lys Ala Leu Ile Tyr Gln Lys Lys Tyr Leu Leu Leu
        3715                3720                3725            
Leu Leu Gly Gly Phe Gln Glu Cys Glu Asp Ala Thr Leu Ala Leu Leu
    3730                3735                3740                
Ala Arg Met Gly Gly Gln Pro Ala Phe Thr Asp Leu Glu Val Ile Thr
3745                3750                3755                3760
Asn Arg Pro Lys Gly Phe Thr Arg Phe Arg Ser Ala Val Arg Val Ser
                3765                3770                3775    
Ile Ala Ile Ser Arg Met Lys Phe Leu Val Arg Arg Trp His Arg Val
            3780                3785                3790        
Thr Gly Ser Val Ser Ile Asn Ile Asn Arg Asp Gly Phe Gly Leu Asn
        3795                3800                3805            
Gln Gly Ala Glu Lys Thr Asp Ser Phe Tyr His Ser Ser Gly Gly Leu
    3810                3815                3820                
Glu Leu Tyr Gly Glu Pro Arg His Thr Thr Tyr Arg Ser Arg Ser Asp
3825                3830                3835                3840
Leu Asp Tyr Ile Arg Ser Pro Leu Pro Phe Gln Asn Arg Tyr Pro Gly
                3845                3850                3855    
Thr Pro Ala Asp Phe Asn Pro Gly Ser Leu Ala Cys Ser Gln Leu Gln
            3860                3865                3870        
Asn Tyr Asp Pro Asp Arg Ala Leu Thr Asp Tyr Ile Thr Arg Leu Glu
        3875                3880                3885            
Ala Leu Gln Arg Arg Leu Gly Thr Ile Gln Ser Gly Ala Leu Ser Leu
    3890                3895                3900                
Thr Thr Ser Trp Gln His His Ser Ala Arg Pro Thr Ala Pro Leu Phe
3905                3910                3915                3920
Phe Glu Ile Leu Ser His Ser Leu Gly
                3925                


<210> 8273
<211> 3907
<212> PRT
<213> Homo sapiens

<400> 8273
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys
 1               5                  10                  15      
Leu Ala Gln Phe Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro
            20                  25                  30          
Ser Lys Lys Gln Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp
        35                  40                  45              
Val Ser Ala His His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu
    50                  55                  60                  
Met Tyr Ile Asn Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu
65                  70                  75                  80  
Ser Thr Ile Met Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu
                85                  90                  95      
Gln Gly Phe Ser Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp
            100                 105                 110         
Asp Cys Ser Ser Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly
        115                 120                 125             
Lys Pro Thr Asn Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser
    130                 135                 140                 
Tyr Ser Glu Gln Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met
145                 150                 155                 160 
Glu Ser Glu Leu Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg
                165                 170                 175     
Glu Leu Glu Glu Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln
            180                 185                 190         
Leu Gln Glu Phe Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr
        195                 200                 205             
Gln Leu Thr Ala Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr
    210                 215                 220                 
Met Arg Glu Phe Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile
225                 230                 235                 240 
Gln Phe Gln Gln Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His
                245                 250                 255     
Ser Ser Thr Ala Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr
            260                 265                 270         
His Gln Gln Gln Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln
        275                 280                 285             
Lys Lys Lys Glu Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys
    290                 295                 300                 
Ile Lys Val Tyr Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn
305                 310                 315                 320 
Lys Glu Glu Ile Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr
                325                 330                 335     
Lys Ile Ile Glu Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu
            340                 345                 350         
Thr Thr Ala Asp Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln
        355                 360                 365             
Lys Asn Gln Glu Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys
    370                 375                 380                 
Gln Lys Glu Arg Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr
385                 390                 395                 400 
Val Glu Glu Leu Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr
                405                 410                 415     
Asp Ile Val Gln Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln
            420                 425                 430         
Leu Arg Ala Glu Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met
        435                 440                 445             
Lys Gln Glu Leu Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys
    450                 455                 460                 
Thr Arg His Lys Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn
465                 470                 475                 480 
Ile Thr Val Asn Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn
                485                 490                 495     
Glu Leu Asn Ile Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu
            500                 505                 510         
Lys Glu Glu Leu Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg
        515                 520                 525             
Gln Leu Glu Asp Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile
    530                 535                 540                 
Gln Arg Ala Arg Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu
545                 550                 555                 560 
Ala His Lys Ser Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val
                565                 570                 575     
Ser Ala Ser Glu Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu
            580                 585                 590         
Val Thr Asn Tyr Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn
        595                 600                 605             
Ala Val Leu Asp Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg
    610                 615                 620                 
Leu Arg Thr Gln Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu
625                 630                 635                 640 
Lys Glu Asp Leu Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys
                645                 650                 655     
Asp Asn Leu Gly Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn
            660                 665                 670         
Glu Met Ser Gln Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu
        675                 680                 685             
Ile Thr Lys Gln Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp
    690                 695                 700                 
Leu Gln Gln Ser Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln
705                 710                 715                 720 
Ile Asn Glu Leu Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys
                725                 730                 735     
Glu Lys Gly Thr Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr
            740                 745                 750         
Glu Leu Leu Glu Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu
        755                 760                 765             
Lys Phe Ala Gln Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys
    770                 775                 780                 
Lys Thr Leu Glu Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu
785                 790                 795                 800 
Glu Arg Leu Ile Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser
                805                 810                 815     
Val Trp Glu Lys Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu
            820                 825                 830         
Lys Gln Gln Cys Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn
        835                 840                 845             
Thr Phe Ser Phe Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu
    850                 855                 860                 
Gln Glu Glu Tyr Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp
865                 870                 875                 880 
Ser Lys Asn Lys Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu
                885                 890                 895     
Asn Glu Glu Leu His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met
            900                 905                 910         
Lys Ser Ser Val Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu
        915                 920                 925             
Glu Met Gly Glu Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys
    930                 935                 940                 
Leu Glu Val Thr Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser
945                 950                 955                 960 
Asp Leu Ser Glu Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu
                965                 970                 975     
Asn Glu Glu Val Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu
            980                 985                 990         
Arg Cys Arg Glu Leu Glu Ile Ile Ile Asn His Asn Arg Ala Glu Asn
        995                 1000                1005            
Val Gln Ser Cys Asp Thr Gln Val Ser Ser Leu Leu Asp Gly Val Val
    1010                1015                1020                
Thr Met Thr Ser Arg Gly Ala Glu Gly Ser Val Ser Lys Val Asn Lys
1025                1030                1035                1040
Ser Phe Gly Glu Glu Ser Lys Ile Met Val Glu Asp Lys Val Ser Phe
                1045                1050                1055    
Glu Asn Met Thr Val Gly Glu Glu Ser Lys Gln Glu Gln Leu Ile Leu
            1060                1065                1070        
Asp His Leu Pro Ser Val Thr Lys Glu Ser Ser Leu Arg Ala Thr Gln
        1075                1080                1085            
Pro Ser Glu Asn Asp Lys Leu Gln Lys Glu Leu Asn Val Leu Lys Ser
    1090                1095                1100                
Glu Gln Asn Asp Leu Arg Leu Gln Met Glu Ala Gln Arg Ile Cys Leu
1105                1110                1115                1120
Ser Leu Val Tyr Ser Thr His Val Asp Gln Val Arg Glu Tyr Met Glu
                1125                1130                1135    
Asn Glu Lys Asp Lys Ala Leu Cys Ser Leu Lys Glu Glu Leu Ile Phe
            1140                1145                1150        
Ala Gln Glu Glu Lys Ile Lys Glu Leu Gln Lys Ile His Gln Leu Glu
        1155                1160                1165            
Leu Gln Thr Met Lys Thr Gln Glu Thr Gly Asp Glu Gly Lys Pro Leu
    1170                1175                1180                
His Leu Leu Ile Gly Lys Leu Gln Lys Ala Val Ser Glu Glu Cys Ser
1185                1190                1195                1200
Tyr Phe Leu Gln Thr Leu Cys Ser Val Leu Gly Glu Tyr Tyr Thr Pro
                1205                1210                1215    
Ala Leu Lys Cys Glu Val Asn Ala Glu Asp Lys Glu Asn Ser Gly Asp
            1220                1225                1230        
Tyr Ile Ser Glu Asn Glu Asp Pro Glu Leu Gln Asp Tyr Arg Tyr Glu
        1235                1240                1245            
Val Gln Asp Phe Gln Glu Asn Met His Thr Leu Leu Asn Lys Val Thr
    1250                1255                1260                
Glu Glu Tyr Asn Lys Leu Leu Val Leu Gln Thr Arg Leu Ser Lys Ile
1265                1270                1275                1280
Trp Gly Gln Gln Thr Asp Gly Met Lys Leu Glu Phe Gly Glu Glu Asn
                1285                1290                1295    
Leu Pro Lys Glu Glu Thr Glu Phe Leu Ser Ile His Ser Gln Met Thr
            1300                1305                1310        
Asn Leu Glu Asp Ile Asp Val Asn His Lys Ser Lys Leu Ser Ser Leu
        1315                1320                1325            
Gln Asp Leu Glu Lys Thr Lys Leu Glu Glu Gln Val Gln Glu Leu Glu
    1330                1335                1340                
Ser Leu Ile Ser Ser Leu Gln Gln Gln Leu Lys Glu Thr Glu Gln Asn
1345                1350                1355                1360
Tyr Glu Ala Glu Ile His Cys Leu Gln Lys Arg Leu Gln Ala Val Ser
                1365                1370                1375    
Glu Ser Thr Val Pro Pro Ser Leu Pro Val Asp Ser Val Val Ile Thr
            1380                1385                1390        
Glu Ser Asp Ala Gln Arg Thr Met Tyr Pro Gly Ser Cys Val Lys Lys
        1395                1400                1405            
Asn Ile Asp Gly Thr Ile Glu Phe Ser Gly Glu Phe Gly Val Lys Glu
    1410                1415                1420                
Glu Thr Asn Ile Val Lys Leu Leu Glu Lys Gln Tyr Gln Glu Gln Leu
1425                1430                1435                1440
Glu Glu Glu Val Ala Lys Val Ile Val Ser Met Ser Ile Ala Phe Ala
                1445                1450                1455    
Gln Gln Thr Glu Leu Ser Arg Ile Ser Gly Gly Lys Glu Asn Thr Ala
            1460                1465                1470        
Ser Ser Lys Gln Ala His Ala Val Cys Gln Gln Glu Gln His Tyr Phe
        1475                1480                1485            
Asn Glu Met Lys Leu Ser Gln Asp Gln Ile Gly Phe Gln Thr Phe Glu
    1490                1495                1500                
Thr Val Asp Val Lys Phe Lys Glu Glu Phe Lys Pro Leu Ser Lys Glu
1505                1510                1515                1520
Leu Gly Glu His Gly Lys Glu Ile Leu Leu Ser Asn Ser Asp Pro His
                1525                1530                1535    
Asp Ile Pro Glu Ser Lys Asp Cys Val Leu Thr Ile Ser Glu Glu Met
            1540                1545                1550        
Phe Ser Lys Asp Lys Thr Phe Ile Val Arg Gln Ser Ile His Asp Glu
        1555                1560                1565            
Ile Ser Val Ser Ser Met Asp Ala Ser Arg Gln Leu Met Leu Asn Glu
    1570                1575                1580                
Glu Gln Leu Glu Asp Met Arg Gln Glu Leu Val Arg Gln Tyr Gln Glu
1585                1590                1595                1600
His Gln Gln Ala Thr Glu Leu Leu Arg Gln Ala His Met Arg Gln Met
                1605                1610                1615    
Glu Arg Gln Arg Glu Asp Gln Glu Gln Leu Gln Glu Glu Ile Lys Arg
            1620                1625                1630        
Leu Asn Arg Gln Leu Ala Gln Arg Ser Ser Ile Asp Asn Glu Asn Leu
        1635                1640                1645            
Val Ser Glu Arg Glu Arg Val Leu Leu Glu Glu Leu Glu Ala Leu Lys
    1650                1655                1660                
Gln Leu Ser Leu Ala Gly Arg Glu Lys Leu Cys Cys Glu Leu Arg Asn
1665                1670                1675                1680
Ser Ser Thr Gln Thr Gln Asn Gly Asn Glu Asn Gln Gly Glu Val Glu
                1685                1690                1695    
Glu Gln Thr Phe Lys Glu Lys Glu Leu Asp Arg Lys Pro Glu Asp Val
            1700                1705                1710        
Pro Pro Glu Ile Leu Ser Asn Glu Arg Tyr Ala Leu Gln Lys Ala Asn
        1715                1720                1725            
Asn Arg Leu Leu Lys Ile Leu Leu Glu Val Val Lys Thr Thr Ala Ala
    1730                1735                1740                
Val Glu Glu Thr Ile Gly Arg His Val Leu Gly Ile Leu Asp Arg Ser
1745                1750                1755                1760
Ser Lys Ser Gln Ser Ser Ala Ser Leu Ile Trp Arg Ser Glu Ala Glu
                1765                1770                1775    
Ala Ser Val Lys Ser Cys Val His Glu Glu His Thr Arg Val Thr Asp
            1780                1785                1790        
Glu Ser Ile Pro Ser Tyr Ser Gly Ser Asp Met Pro Arg Asn Asp Ile
        1795                1800                1805            
Asn Met Trp Ser Lys Val Thr Glu Glu Gly Thr Glu Leu Ser Gln Arg
    1810                1815                1820                
Leu Val Arg Ser Gly Phe Ala Gly Thr Glu Ile Asp Pro Glu Asn Glu
1825                1830                1835                1840
Glu Leu Met Leu Asn Ile Ser Ser Arg Leu Gln Ala Ala Val Glu Lys
                1845                1850                1855    
Leu Leu Glu Ala Ile Ser Glu Thr Ser Ser Gln Leu Glu His Ala Lys
            1860                1865                1870        
Val Thr Gln Thr Glu Leu Met Arg Glu Ser Phe Arg Gln Lys Gln Glu
        1875                1880                1885            
Ala Thr Glu Ser Leu Lys Cys Gln Glu Glu Leu Arg Glu Arg Leu His
    1890                1895                1900                
Glu Glu Ser Arg Ala Arg Glu Gln Leu Ala Val Glu Leu Ser Lys Ala
1905                1910                1915                1920
Glu Gly Val Ile Asp Gly Tyr Ala Asp Glu Lys Thr Leu Phe Glu Arg
                1925                1930                1935    
Gln Ile Gln Glu Lys Thr Asp Ile Ile Asp Arg Leu Glu Gln Glu Leu
            1940                1945                1950        
Leu Cys Ala Ser Asn Arg Leu Gln Glu Leu Glu Ala Glu Gln Gln Gln
        1955                1960                1965            
Ile Gln Glu Glu Arg Glu Leu Leu Ser Arg Gln Lys Glu Ala Met Lys
    1970                1975                1980                
Ala Glu Ala Gly Pro Val Glu Gln Gln Leu Leu Gln Glu Thr Glu Lys
1985                1990                1995                2000
Leu Met Lys Glu Lys Leu Glu Val Gln Cys Gln Ala Glu Lys Val Arg
                2005                2010                2015    
Asp Asp Leu Gln Lys Gln Val Lys Ala Leu Glu Ile Asp Val Glu Glu
            2020                2025                2030        
Gln Val Ser Arg Phe Ile Glu Leu Glu Gln Glu Lys Asn Thr Glu Leu
        2035                2040                2045            
Met Asp Leu Arg Gln Gln Asn Gln Ala Leu Glu Lys Gln Leu Glu Lys
    2050                2055                2060                
Met Arg Lys Phe Leu Asp Glu Gln Ala Ile Asp Arg Glu His Glu Arg
2065                2070                2075                2080
Asp Val Phe Gln Gln Glu Ile Gln Lys Leu Glu Gln Gln Leu Lys Val
                2085                2090                2095    
Val Pro Arg Phe Gln Pro Ile Ser Glu His Gln Thr Arg Glu Val Glu
            2100                2105                2110        
Gln Leu Ala Asn His Leu Lys Glu Lys Thr Asp Lys Cys Ser Glu Leu
        2115                2120                2125            
Leu Leu Ser Lys Glu Gln Leu Gln Arg Asp Ile Gln Glu Arg Asn Glu
    2130                2135                2140                
Glu Ile Glu Lys Leu Glu Phe Arg Val Arg Glu Leu Glu Gln Ala Leu
2145                2150                2155                2160
Leu Val Ser Ala Asp Thr Phe Gln Lys Val Glu Asp Arg Lys His Phe
                2165                2170                2175    
Gly Ala Val Glu Ala Lys Pro Glu Leu Ser Leu Glu Val Gln Leu Gln
            2180                2185                2190        
Ala Glu Arg Asp Ala Ile Asp Arg Lys Glu Lys Glu Ile Thr Asn Leu
        2195                2200                2205            
Glu Glu Gln Leu Glu Gln Phe Arg Glu Glu Leu Glu Asn Lys Asn Glu
    2210                2215                2220                
Glu Val Gln Gln Leu His Met Gln Leu Glu Ile Gln Lys Lys Glu Ser
2225                2230                2235                2240
Thr Thr Arg Leu Gln Glu Leu Glu Gln Glu Asn Lys Leu Phe Lys Asp
                2245                2250                2255    
Asp Met Glu Lys Leu Gly Leu Ala Ile Lys Glu Ser Asp Ala Met Ser
            2260                2265                2270        
Thr Gln Asp Gln His Val Leu Phe Gly Lys Phe Ala Gln Ile Ile Gln
        2275                2280                2285            
Glu Lys Glu Val Glu Ile Asp Gln Leu Asn Glu Gln Val Thr Lys Leu
    2290                2295                2300                
Gln Gln Gln Leu Lys Ile Thr Thr Asp Asn Lys Val Ile Glu Glu Lys
2305                2310                2315                2320
Asn Glu Leu Ile Arg Asp Leu Glu Thr Gln Ile Glu Cys Leu Met Ser
                2325                2330                2335    
Asp Gln Glu Cys Val Lys Arg Asn Arg Glu Glu Glu Ile Glu Gln Leu
            2340                2345                2350        
Asn Glu Val Ile Glu Lys Leu Gln Gln Glu Leu Ala Asn Ile Gly Gln
        2355                2360                2365            
Lys Thr Ser Met Asn Ala His Ser Leu Ser Glu Glu Ala Asp Ser Leu
    2370                2375                2380                
Lys His Gln Leu Asp Val Val Ile Ala Glu Lys Leu Ala Leu Glu Gln
2385                2390                2395                2400
Gln Val Glu Thr Ala Asn Glu Glu Met Thr Phe Met Lys Asn Val Leu
                2405                2410                2415    
Lys Glu Thr Asn Phe Lys Met Asn Gln Leu Thr Gln Glu Leu Phe Ser
            2420                2425                2430        
Leu Lys Arg Glu Arg Glu Ser Val Glu Lys Ile Gln Ser Ile Pro Glu
        2435                2440                2445            
Asn Ser Val Asn Val Ala Ile Asp His Leu Ser Lys Asp Lys Pro Glu
    2450                2455                2460                
Leu Glu Val Val Leu Thr Glu Asp Ala Leu Lys Ser Leu Glu Asn Gln
2465                2470                2475                2480
Thr Tyr Phe Lys Ser Phe Glu Glu Asn Gly Lys Gly Ser Ile Ile Asn
                2485                2490                2495    
Leu Glu Thr Arg Leu Leu Gln Leu Glu Ser Thr Val Ser Ala Lys Asp
            2500                2505                2510        
Leu Glu Leu Thr Gln Cys Tyr Lys Gln Ile Lys Asp Met Gln Glu Gln
        2515                2520                2525            
Gly Gln Phe Glu Thr Glu Met Leu Gln Lys Lys Ile Val Asn Leu Gln
    2530                2535                2540                
Lys Ile Val Glu Glu Lys Val Ala Ala Ala Leu Val Ser Gln Ile Gln
2545                2550                2555                2560
Leu Glu Ala Val Gln Glu Tyr Ala Lys Phe Cys Gln Asp Asn Gln Thr
                2565                2570                2575    
Ile Ser Ser Glu Pro Glu Arg Thr Asn Ile Gln Asn Leu Asn Gln Leu
            2580                2585                2590        
Arg Glu Asp Glu Leu Gly Ser Asp Ile Ser Ala Leu Thr Leu Arg Ile
        2595                2600                2605            
Ser Glu Leu Glu Ser Gln Val Val Glu Met His Thr Ser Leu Ile Leu
    2610                2615                2620                
Glu Lys Glu Gln Val Glu Ile Ala Glu Lys Asn Val Leu Glu Lys Glu
2625                2630                2635                2640
Lys Lys Leu Leu Glu Leu Gln Lys Leu Leu Glu Gly Asn Glu Lys Lys
                2645                2650                2655    
Gln Arg Glu Lys Glu Lys Lys Arg Ser Pro Gln Asp Val Glu Val Leu
            2660                2665                2670        
Lys Thr Thr Thr Glu Leu Phe His Ser Asn Glu Glu Ser Gly Phe Phe
        2675                2680                2685            
Asn Glu Leu Glu Ala Leu Arg Ala Glu Ser Val Ala Thr Lys Ala Glu
    2690                2695                2700                
Leu Ala Ser Tyr Lys Glu Lys Ala Glu Lys Leu Gln Glu Glu Leu Leu
2705                2710                2715                2720
Val Lys Glu Thr Asn Met Thr Ser Leu Gln Lys Asp Leu Ser Gln Val
                2725                2730                2735    
Arg Asp His Leu Ala Glu Ala Lys Glu Lys Leu Ser Ile Leu Glu Lys
            2740                2745                2750        
Glu Asp Glu Thr Glu Val Gln Glu Ser Lys Lys Ala Cys Met Phe Glu
        2755                2760                2765            
Pro Leu Pro Ile Lys Leu Ser Lys Ser Ile Ala Ser Gln Thr Asp Gly
    2770                2775                2780                
Thr Leu Lys Ile Ser Ser Ser Asn Gln Thr Pro Gln Ile Leu Val Lys
2785                2790                2795                2800
Asn Ala Gly Ile Gln Ile Asn Leu Gln Ser Glu Cys Ser Ser Glu Glu
                2805                2810                2815    
Val Thr Glu Ile Ile Ser Gln Phe Thr Glu Lys Ile Glu Lys Met Gln
            2820                2825                2830        
Glu Leu His Ala Ala Glu Ile Leu Asp Met Glu Ser Arg His Ile Ser
        2835                2840                2845            
Glu Thr Glu Thr Leu Lys Arg Glu His Tyr Val Ala Val Gln Leu Leu
    2850                2855                2860                
Lys Glu Glu Cys Gly Thr Leu Lys Ala Val Ile Gln Cys Leu Arg Ser
2865                2870                2875                2880
Lys Glu Gly Ser Ser Ile Pro Glu Leu Ala His Ser Asp Ala Tyr Gln
                2885                2890                2895    
Thr Arg Glu Ile Cys Ser Ser Asp Ser Gly Ser Asp Trp Gly Gln Gly
            2900                2905                2910        
Ile Tyr Leu Thr His Ser Gln Gly Phe Asp Ile Ala Ser Glu Gly Arg
        2915                2920                2925            
Gly Glu Glu Ser Glu Ser Ala Thr Asp Ser Phe Pro Lys Lys Ile Lys
    2930                2935                2940                
Gly Leu Leu Arg Ala Val His Asn Glu Gly Met Gln Val Leu Ser Leu
2945                2950                2955                2960
Thr Glu Ser Pro Tyr Ser Asp Gly Glu Asp His Ser Ile Gln Gln Val
                2965                2970                2975    
Ser Glu Pro Trp Leu Glu Glu Arg Lys Ala Tyr Ile Asn Thr Ile Ser
            2980                2985                2990        
Ser Leu Lys Asp Leu Ile Thr Lys Met Gln Leu Gln Arg Glu Ala Glu
        2995                3000                3005            
Val Tyr Asp Ser Ser Gln Ser His Glu Ser Phe Ser Asp Trp Arg Gly
    3010                3015                3020                
Glu Leu Leu Leu Ala Leu Gln Gln Val Phe Leu Glu Glu Arg Ser Val
3025                3030                3035                3040
Leu Leu Ala Ala Phe Arg Thr Glu Leu Thr Ala Leu Gly Thr Thr Asp
                3045                3050                3055    
Ala Val Gly Leu Leu Asn Cys Leu Glu Gln Arg Ile Gln Glu Gln Gly
            3060                3065                3070        
Val Glu Tyr Gln Ala Ala Met Glu Cys Leu Gln Lys Ala Asp Arg Arg
        3075                3080                3085            
Ser Leu Leu Ser Glu Ile Gln Ala Leu His Ala Gln Met Asn Gly Arg
    3090                3095                3100                
Lys Ile Thr Leu Lys Arg Glu Gln Glu Ser Glu Lys Pro Ser Gln Glu
3105                3110                3115                3120
Leu Leu Glu Tyr Asn Ile Gln Gln Lys Gln Ser Gln Met Leu Glu Met
                3125                3130                3135    
Gln Val Glu Leu Ser Ser Met Lys Asp Arg Ala Thr Glu Leu Gln Glu
            3140                3145                3150        
Gln Leu Ser Ser Glu Lys Met Val Val Ala Glu Leu Lys Ser Glu Leu
        3155                3160                3165            
Ala Gln Thr Lys Leu Glu Leu Glu Thr Thr Leu Lys Ala Gln His Lys
    3170                3175                3180                
His Leu Lys Glu Leu Glu Ala Phe Arg Leu Glu Val Lys Asp Lys Thr
3185                3190                3195                3200
Asp Glu Val His Leu Leu Asn Asp Thr Leu Ala Ser Glu Gln Lys Lys
                3205                3210                3215    
Ser Arg Glu Leu Gln Trp Ala Leu Glu Lys Glu Lys Ala Lys Leu Gly
            3220                3225                3230        
Arg Ser Glu Glu Arg Asp Lys Glu Glu Leu Glu Asp Leu Lys Phe Ser
        3235                3240                3245            
Leu Glu Ser Gln Lys Gln Arg Asn Leu Gln Leu Asn Leu Leu Leu Glu
    3250                3255                3260                
Gln Gln Lys Gln Leu Leu Asn Glu Ser Gln Gln Lys Ile Glu Ser Gln
3265                3270                3275                3280
Arg Met Leu Tyr Asp Ala Gln Leu Ser Glu Glu Gln Gly Arg Asn Leu
                3285                3290                3295    
Glu Leu Gln Val Leu Leu Glu Ser Glu Lys Val Arg Ile Arg Glu Met
            3300                3305                3310        
Ser Ser Thr Leu Asp Arg Glu Arg Glu Leu His Ala Gln Leu Gln Ser
        3315                3320                3325            
Ser Asp Gly Thr Gly Gln Ser Arg Pro Pro Leu Pro Ser Glu Asp Leu
    3330                3335                3340                
Leu Lys Glu Leu Gln Lys Gln Leu Glu Glu Lys His Ser Arg Ile Val
3345                3350                3355                3360
Glu Leu Leu Asn Glu Thr Glu Lys Tyr Lys Leu Asp Ser Leu Gln Thr
                3365                3370                3375    
Arg Gln Gln Met Glu Lys Asp Arg Gln Val His Arg Lys Thr Leu Gln
            3380                3385                3390        
Thr Glu Gln Glu Ala Asn Thr Glu Gly Gln Lys Lys Met His Glu Leu
        3395                3400                3405            
Gln Ser Lys Val Glu Asp Leu Gln Arg Gln Leu Glu Glu Lys Arg Gln
    3410                3415                3420                
Gln Val Tyr Lys Leu Asp Leu Glu Gly Gln Arg Leu Gln Gly Ile Met
3425                3430                3435                3440
Gln Glu Phe Gln Lys Gln Glu Leu Glu Arg Glu Glu Lys Arg Glu Ser
                3445                3450                3455    
Arg Arg Ile Leu Tyr Gln Asn Leu Asn Glu Pro Thr Thr Trp Ser Leu
            3460                3465                3470        
Thr Ser Asp Arg Thr Arg Asn Trp Val Leu Gln Gln Lys Ile Glu Gly
        3475                3480                3485            
Glu Thr Lys Glu Ser Asn Tyr Ala Lys Leu Ile Glu Met Asn Gly Gly
    3490                3495                3500                
Gly Thr Gly Cys Asn His Glu Leu Glu Met Ile Arg Gln Lys Leu Gln
3505                3510                3515                3520
Cys Val Ala Ser Lys Leu Gln Val Leu Pro Gln Lys Ala Ser Glu Arg
                3525                3530                3535    
Leu Gln Phe Glu Thr Ala Asp Asp Glu Asp Phe Ile Trp Val Gln Glu
            3540                3545                3550        
Asn Ile Asp Glu Ile Ile Leu Gln Leu Gln Lys Leu Thr Gly Gln Gln
        3555                3560                3565            
Gly Glu Glu Pro Ser Leu Val Ser Pro Ser Thr Ser Cys Gly Ser Leu
    3570                3575                3580                
Thr Glu Arg Leu Leu Arg Gln Asn Ala Glu Leu Thr Gly His Ile Ser
3585                3590                3595                3600
Gln Leu Thr Glu Glu Lys Asn Asp Leu Arg Asn Met Val Met Lys Leu
                3605                3610                3615    
Glu Glu Gln Ile Arg Trp Tyr Arg Gln Thr Gly Ala Gly Arg Asp Asn
            3620                3625                3630        
Ser Ser Arg Phe Ser Leu Asn Gly Gly Ala Asn Ile Glu Ala Ile Ile
        3635                3640                3645            
Ala Ser Glu Lys Glu Val Trp Asn Arg Glu Lys Leu Thr Leu Gln Lys
    3650                3655                3660                
Ser Leu Lys Arg Ala Glu Ala Glu Val Tyr Lys Leu Lys Ala Glu Leu
3665                3670                3675                3680
Arg Asn Asp Ser Leu Leu Gln Thr Leu Ser Pro Asp Ser Glu His Val
                3685                3690                3695    
Thr Leu Lys Arg Ile Tyr Gly Lys Tyr Leu Arg Ala Glu Ser Phe Arg
            3700                3705                3710        
Lys Ala Leu Ile Tyr Gln Lys Lys Tyr Leu Leu Leu Leu Leu Gly Gly
        3715                3720                3725            
Phe Gln Glu Cys Glu Asp Ala Thr Leu Ala Leu Leu Ala Arg Met Gly
    3730                3735                3740                
Gly Gln Pro Ala Phe Thr Asp Leu Glu Val Ile Thr Asn Arg Pro Lys
3745                3750                3755                3760
Gly Phe Thr Arg Phe Arg Ser Ala Val Arg Val Ser Ile Ala Ile Ser
                3765                3770                3775    
Arg Met Lys Phe Leu Val Arg Arg Trp His Arg Val Thr Gly Ser Val
            3780                3785                3790        
Ser Ile Asn Ile Asn Arg Asp Gly Phe Gly Leu Asn Gln Gly Ala Glu
        3795                3800                3805            
Lys Thr Asp Ser Phe Tyr His Ser Ser Gly Gly Leu Glu Leu Tyr Gly
    3810                3815                3820                
Glu Pro Arg His Thr Thr Tyr Arg Ser Arg Ser Asp Leu Asp Tyr Ile
3825                3830                3835                3840
Arg Ser Pro Leu Pro Phe Gln Asn Arg Tyr Pro Gly Thr Pro Ala Asp
                3845                3850                3855    
Phe Asn Pro Gly Ser Leu Ala Cys Ser Gln Leu Gln Asn Tyr Asp Pro
            3860                3865                3870        
Asp Arg Ala Leu Thr Asp Tyr Ile Thr Arg Leu Glu Ala Leu Gln Arg
        3875                3880                3885            
Arg Leu Gly Thr Ile Gln Ser Gly Ser Thr Thr Gln Phe His Ala Gly
    3890                3895                3900                
Met Arg Arg
3905        


<210> 8274
<211> 3857
<212> PRT
<213> Homo sapiens

<400> 8274
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys
 1               5                  10                  15      
Ile Glu Glu Leu Ser Leu Ala Phe Leu Val Arg Gln Leu Ala Gln Phe
            20                  25                  30          
Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln
        35                  40                  45              
Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp Val Ser Ala His
    50                  55                  60                  
His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn
65                  70                  75                  80  
Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu Ser Thr Ile Met
                85                  90                  95      
Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu Gln Gly Phe Ser
            100                 105                 110         
Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp Asp Cys Ser Ser
        115                 120                 125             
Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly Lys Pro Thr Asn
    130                 135                 140                 
Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln
145                 150                 155                 160 
Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met Glu Ser Glu Leu
                165                 170                 175     
Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu
            180                 185                 190         
Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln Leu Gln Glu Phe
        195                 200                 205             
Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr Gln Leu Thr Ala
    210                 215                 220                 
Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr Met Arg Glu Phe
225                 230                 235                 240 
Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln
                245                 250                 255     
Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His Ser Ser Thr Ala
            260                 265                 270         
Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr His Gln Gln Gln
        275                 280                 285             
Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu
    290                 295                 300                 
Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr
305                 310                 315                 320 
Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile
                325                 330                 335     
Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr Lys Ile Ile Glu
            340                 345                 350         
Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu Thr Thr Ala Asp
        355                 360                 365             
Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu
    370                 375                 380                 
Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys Gln Lys Glu Arg
385                 390                 395                 400 
Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr Val Glu Glu Leu
                405                 410                 415     
Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr Asp Ile Val Gln
            420                 425                 430         
Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu
        435                 440                 445             
Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu
    450                 455                 460                 
Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys Thr Arg His Lys
465                 470                 475                 480 
Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn Ile Thr Val Asn
                485                 490                 495     
Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile
            500                 505                 510         
Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu
        515                 520                 525             
Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp
    530                 535                 540                 
Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg
545                 550                 555                 560 
Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser
                565                 570                 575     
Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu
            580                 585                 590         
Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu Val Thr Asn Tyr
        595                 600                 605             
Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp
    610                 615                 620                 
Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Thr Gln
625                 630                 635                 640 
Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu
                645                 650                 655     
Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly
            660                 665                 670         
Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln
        675                 680                 685             
Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu Ile Thr Lys Gln
    690                 695                 700                 
Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser
705                 710                 715                 720 
Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln Ile Asn Glu Leu
                725                 730                 735     
Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Thr
            740                 745                 750         
Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr Glu Leu Leu Glu
        755                 760                 765             
Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln
    770                 775                 780                 
Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys Lys Thr Leu Glu
785                 790                 795                 800 
Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu Glu Arg Leu Ile
                805                 810                 815     
Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys
            820                 825                 830         
Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys
        835                 840                 845             
Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn Thr Phe Ser Phe
    850                 855                 860                 
Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr
865                 870                 875                 880 
Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys
                885                 890                 895     
Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu
            900                 905                 910         
His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met Lys Ser Ser Val
        915                 920                 925             
Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu Glu Met Gly Glu
    930                 935                 940                 
Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys Leu Glu Val Thr
945                 950                 955                 960 
Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu
                965                 970                 975     
Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val
            980                 985                 990         
Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu Arg Cys Arg Glu
        995                 1000                1005            
Leu Glu Ile Ile Ile Asn His Asn Arg Ala Glu Asn Val Gln Ser Cys
    1010                1015                1020                
Asp Thr Gln Val Ser Ser Leu Leu Asp Gly Val Val Thr Met Thr Ser
1025                1030                1035                1040
Arg Gly Ala Glu Gly Ser Val Ser Lys Val Asn Lys Ser Phe Gly Glu
                1045                1050                1055    
Glu Ser Lys Ile Met Val Glu Asp Lys Val Ser Phe Glu Asn Met Thr
            1060                1065                1070        
Val Gly Glu Glu Ser Lys Gln Glu Gln Leu Ile Leu Asp His Leu Pro
        1075                1080                1085            
Ser Val Thr Lys Glu Ser Ser Leu Arg Ala Thr Gln Pro Ser Glu Asn
    1090                1095                1100                
Asp Lys Leu Gln Lys Glu Leu Asn Val Leu Lys Ser Glu Gln Asn Asp
1105                1110                1115                1120
Leu Arg Leu Gln Met Glu Ala Gln Arg Ile Cys Leu Ser Leu Val Tyr
                1125                1130                1135    
Ser Thr His Val Asp Gln Val Arg Glu Tyr Met Glu Asn Glu Lys Asp
            1140                1145                1150        
Lys Ala Leu Cys Ser Leu Lys Glu Glu Leu Ile Phe Ala Gln Glu Glu
        1155                1160                1165            
Lys Ile Lys Glu Leu Gln Lys Ile His Gln Leu Glu Leu Gln Thr Met
    1170                1175                1180                
Lys Thr Gln Glu Thr Gly Asp Glu Gly Lys Pro Leu His Leu Leu Ile
1185                1190                1195                1200
Gly Lys Leu Gln Lys Ala Val Ser Glu Glu Cys Ser Tyr Phe Leu Gln
                1205                1210                1215    
Thr Leu Cys Ser Val Leu Gly Glu Tyr Tyr Thr Pro Ala Leu Lys Cys
            1220                1225                1230        
Glu Val Asn Ala Glu Asp Lys Glu Asn Ser Gly Asp Tyr Ile Ser Glu
        1235                1240                1245            
Asn Glu Asp Pro Glu Leu Gln Asp Tyr Arg Tyr Glu Val Gln Asp Phe
    1250                1255                1260                
Gln Glu Asn Met His Thr Leu Leu Asn Lys Val Thr Glu Glu Tyr Asn
1265                1270                1275                1280
Lys Leu Leu Val Leu Gln Thr Arg Leu Ser Lys Ile Trp Gly Gln Gln
                1285                1290                1295    
Thr Asp Gly Met Lys Leu Glu Phe Gly Glu Glu Asn Leu Pro Lys Glu
            1300                1305                1310        
Glu Thr Glu Phe Leu Ser Ile His Ser Gln Met Thr Asn Leu Glu Asp
        1315                1320                1325            
Ile Asp Val Asn His Lys Ser Lys Leu Ser Ser Leu Gln Asp Leu Glu
    1330                1335                1340                
Lys Thr Lys Leu Glu Glu Gln Val Gln Glu Leu Glu Ser Leu Ile Ser
1345                1350                1355                1360
Ser Leu Gln Gln Gln Leu Lys Glu Thr Glu Gln Asn Tyr Glu Ala Glu
                1365                1370                1375    
Ile His Cys Leu Gln Lys Arg Leu Gln Ala Val Ser Glu Ser Thr Val
            1380                1385                1390        
Pro Pro Ser Leu Pro Val Asp Ser Val Val Ile Thr Glu Ser Asp Ala
        1395                1400                1405            
Gln Arg Thr Met Tyr Pro Gly Ser Cys Val Lys Lys Asn Ile Asp Gly
    1410                1415                1420                
Thr Ile Glu Phe Ser Gly Glu Phe Gly Val Lys Glu Glu Thr Asn Ile
1425                1430                1435                1440
Val Lys Leu Leu Glu Lys Gln Tyr Gln Glu Gln Leu Glu Glu Glu Val
                1445                1450                1455    
Ala Lys Val Ile Val Ser Met Ser Ile Ala Phe Ala Gln Gln Thr Glu
            1460                1465                1470        
Leu Ser Arg Ile Ser Gly Gly Lys Glu Asn Thr Ala Ser Ser Lys Gln
        1475                1480                1485            
Ala His Ala Val Cys Gln Gln Glu Gln His Tyr Phe Asn Glu Met Lys
    1490                1495                1500                
Leu Ser Gln Asp Gln Ile Gly Phe Gln Thr Phe Glu Thr Val Asp Val
1505                1510                1515                1520
Lys Phe Lys Glu Glu Phe Lys Pro Leu Ser Lys Glu Leu Gly Glu His
                1525                1530                1535    
Gly Lys Glu Ile Leu Leu Ser Asn Ser Asp Pro His Asp Ile Pro Glu
            1540                1545                1550        
Ser Lys Asp Cys Val Leu Thr Ile Ser Glu Glu Met Phe Ser Lys Asp
        1555                1560                1565            
Lys Thr Phe Ile Val Arg Gln Ser Ile His Asp Glu Ile Ser Val Ser
    1570                1575                1580                
Ser Met Asp Ala Ser Arg Gln Leu Met Leu Asn Glu Glu Gln Leu Glu
1585                1590                1595                1600
Asp Met Arg Gln Glu Leu Val Arg Gln Tyr Gln Glu His Gln Gln Ala
                1605                1610                1615    
Thr Glu Leu Leu Arg Gln Ala His Met Arg Gln Met Glu Arg Gln Arg
            1620                1625                1630        
Glu Asp Gln Glu Gln Leu Gln Glu Glu Ile Lys Arg Leu Asn Arg Gln
        1635                1640                1645            
Leu Ala Gln Arg Ser Ser Ile Asp Asn Glu Asn Leu Val Ser Glu Arg
    1650                1655                1660                
Glu Arg Val Leu Leu Glu Glu Leu Glu Ala Leu Lys Gln Leu Ser Leu
1665                1670                1675                1680
Ala Gly Arg Glu Lys Leu Cys Cys Glu Leu Arg Asn Ser Ser Thr Gln
                1685                1690                1695    
Thr Gln Asn Gly Asn Glu Asn Gln Gly Glu Val Glu Glu Gln Thr Phe
            1700                1705                1710        
Lys Glu Lys Glu Leu Asp Arg Lys Pro Glu Asp Val Pro Pro Glu Ile
        1715                1720                1725            
Leu Ser Asn Glu Arg Tyr Ala Leu Gln Lys Ala Asn Asn Arg Leu Leu
    1730                1735                1740                
Lys Ile Leu Leu Glu Val Val Lys Thr Thr Ala Ala Val Glu Glu Thr
1745                1750                1755                1760
Ile Gly Arg His Val Leu Gly Ile Leu Asp Arg Ser Ser Lys Ser Gln
                1765                1770                1775    
Ser Ser Ala Ser Leu Ile Trp Arg Ser Glu Ala Glu Ala Ser Val Lys
            1780                1785                1790        
Ser Cys Val His Glu Glu His Thr Arg Val Thr Asp Glu Ser Ile Pro
        1795                1800                1805            
Ser Tyr Ser Gly Ser Asp Met Pro Arg Asn Asp Ile Asn Met Trp Ser
    1810                1815                1820                
Lys Val Thr Glu Glu Gly Thr Glu Leu Ser Gln Arg Leu Val Arg Ser
1825                1830                1835                1840
Gly Phe Ala Gly Thr Glu Ile Asp Pro Glu Asn Glu Glu Leu Met Leu
                1845                1850                1855    
Asn Ile Ser Ser Arg Leu Gln Ala Ala Val Glu Lys Leu Leu Glu Ala
            1860                1865                1870        
Ile Ser Glu Thr Ser Ser Gln Leu Glu His Ala Lys Val Thr Gln Thr
        1875                1880                1885            
Glu Leu Met Arg Glu Ser Phe Arg Gln Lys Gln Glu Ala Thr Glu Ser
    1890                1895                1900                
Leu Lys Cys Gln Glu Glu Leu Arg Glu Arg Leu His Glu Glu Ser Arg
1905                1910                1915                1920
Ala Arg Glu Gln Leu Ala Val Glu Leu Ser Lys Ala Glu Gly Val Ile
                1925                1930                1935    
Asp Gly Tyr Ala Asp Glu Lys Thr Leu Phe Glu Arg Gln Ile Gln Glu
            1940                1945                1950        
Lys Thr Asp Ile Ile Asp Arg Leu Glu Gln Glu Leu Leu Cys Ala Ser
        1955                1960                1965            
Asn Arg Leu Gln Glu Leu Glu Ala Glu Gln Gln Gln Ile Gln Glu Glu
    1970                1975                1980                
Arg Glu Leu Leu Ser Arg Gln Lys Glu Ala Met Lys Ala Glu Ala Gly
1985                1990                1995                2000
Pro Val Glu Gln Gln Leu Leu Gln Glu Thr Glu Lys Leu Met Lys Glu
                2005                2010                2015    
Lys Leu Glu Val Gln Cys Gln Ala Glu Lys Val Arg Asp Asp Leu Gln
            2020                2025                2030        
Lys Gln Val Lys Ala Leu Glu Ile Asp Val Glu Glu Gln Val Ser Arg
        2035                2040                2045            
Phe Ile Glu Leu Glu Gln Glu Lys Asn Thr Glu Leu Met Asp Leu Arg
    2050                2055                2060                
Gln Gln Asn Gln Ala Leu Glu Lys Gln Leu Glu Lys Met Arg Lys Phe
2065                2070                2075                2080
Leu Asp Glu Gln Ala Ile Asp Arg Glu His Glu Arg Asp Val Phe Gln
                2085                2090                2095    
Gln Glu Ile Gln Lys Leu Glu Gln Gln Leu Lys Val Val Pro Arg Phe
            2100                2105                2110        
Gln Pro Ile Ser Glu His Gln Thr Arg Glu Val Glu Gln Leu Ala Asn
        2115                2120                2125            
His Leu Lys Glu Lys Thr Asp Lys Cys Ser Glu Leu Leu Leu Ser Lys
    2130                2135                2140                
Glu Gln Leu Gln Arg Asp Ile Gln Glu Arg Asn Glu Glu Ile Glu Lys
2145                2150                2155                2160
Leu Glu Phe Arg Val Arg Glu Leu Glu Gln Ala Leu Leu Val Ser Ala
                2165                2170                2175    
Asp Thr Phe Gln Lys Val Glu Asp Arg Lys His Phe Gly Ala Val Glu
            2180                2185                2190        
Ala Lys Pro Glu Leu Ser Leu Glu Val Gln Leu Gln Ala Glu Arg Asp
        2195                2200                2205            
Ala Ile Asp Arg Lys Glu Lys Glu Ile Thr Asn Leu Glu Glu Gln Leu
    2210                2215                2220                
Glu Gln Phe Arg Glu Glu Leu Glu Asn Lys Asn Glu Glu Val Gln Gln
2225                2230                2235                2240
Leu His Met Gln Leu Glu Ile Gln Lys Lys Glu Ser Thr Thr Arg Leu
                2245                2250                2255    
Gln Glu Leu Glu Gln Glu Asn Lys Leu Phe Lys Asp Asp Met Glu Lys
            2260                2265                2270        
Leu Gly Leu Ala Ile Lys Glu Ser Asp Ala Met Ser Thr Gln Asp Gln
        2275                2280                2285            
His Val Leu Phe Gly Lys Phe Ala Gln Ile Ile Gln Glu Lys Glu Val
    2290                2295                2300                
Glu Ile Asp Gln Leu Asn Glu Gln Val Thr Lys Leu Gln Gln Gln Leu
2305                2310                2315                2320
Lys Ile Thr Thr Asp Asn Lys Val Ile Glu Glu Lys Asn Glu Leu Ile
                2325                2330                2335    
Arg Asp Leu Glu Thr Gln Ile Glu Cys Leu Met Ser Asp Gln Glu Cys
            2340                2345                2350        
Val Lys Arg Asn Arg Glu Glu Glu Ile Glu Gln Leu Asn Glu Val Ile
        2355                2360                2365            
Glu Lys Leu Gln Gln Glu Leu Ala Asn Ile Gly Gln Lys Thr Ser Met
    2370                2375                2380                
Asn Ala His Ser Leu Ser Glu Glu Ala Asp Ser Leu Lys His Gln Leu
2385                2390                2395                2400
Asp Val Val Ile Ala Glu Lys Leu Ala Leu Glu Gln Gln Val Glu Thr
                2405                2410                2415    
Ala Asn Glu Glu Met Thr Phe Met Lys Asn Val Leu Lys Glu Thr Asn
            2420                2425                2430        
Phe Lys Met Asn Gln Leu Thr Gln Glu Leu Phe Ser Leu Lys Arg Glu
        2435                2440                2445            
Arg Glu Ser Val Glu Lys Ile Gln Ser Ile Pro Glu Asn Ser Val Asn
    2450                2455                2460                
Val Ala Ile Asp His Leu Ser Lys Asp Lys Pro Glu Leu Glu Val Val
2465                2470                2475                2480
Leu Thr Glu Asp Ala Leu Lys Ser Leu Glu Asn Gln Thr Tyr Phe Lys
                2485                2490                2495    
Ser Phe Glu Glu Asn Gly Lys Gly Ser Ile Ile Asn Leu Glu Thr Arg
            2500                2505                2510        
Leu Leu Gln Leu Glu Ser Thr Val Ser Ala Lys Asp Leu Glu Leu Thr
        2515                2520                2525            
Gln Cys Tyr Lys Gln Ile Lys Asp Met Gln Glu Gln Gly Gln Phe Glu
    2530                2535                2540                
Thr Glu Met Leu Gln Lys Lys Ile Val Asn Leu Gln Lys Ile Val Glu
2545                2550                2555                2560
Glu Lys Val Ala Ala Ala Leu Val Ser Gln Ile Gln Leu Glu Ala Val
                2565                2570                2575    
Gln Glu Tyr Ala Lys Phe Cys Gln Asp Asn Gln Thr Ile Ser Ser Glu
            2580                2585                2590        
Pro Glu Arg Thr Asn Ile Gln Asn Leu Asn Gln Leu Arg Glu Asp Glu
        2595                2600                2605            
Leu Gly Ser Asp Ile Ser Ala Leu Thr Leu Arg Ile Ser Glu Leu Glu
    2610                2615                2620                
Ser Gln Val Val Glu Met His Thr Ser Leu Ile Leu Glu Lys Glu Gln
2625                2630                2635                2640
Val Glu Ile Ala Glu Lys Asn Val Leu Glu Lys Glu Lys Lys Leu Leu
                2645                2650                2655    
Glu Leu Gln Lys Leu Leu Glu Gly Asn Glu Lys Lys Gln Arg Glu Lys
            2660                2665                2670        
Glu Lys Lys Arg Ser Pro Gln Asp Val Glu Val Leu Lys Thr Thr Thr
        2675                2680                2685            
Glu Leu Phe His Ser Asn Glu Glu Ser Gly Phe Phe Asn Glu Leu Glu
    2690                2695                2700                
Ala Leu Arg Ala Glu Ser Val Ala Thr Lys Ala Glu Leu Ala Ser Tyr
2705                2710                2715                2720
Lys Glu Lys Ala Glu Lys Leu Gln Glu Glu Leu Leu Val Lys Glu Thr
                2725                2730                2735    
Asn Met Thr Ser Leu Gln Lys Asp Leu Ser Gln Val Arg Asp His Leu
            2740                2745                2750        
Ala Glu Ala Lys Glu Lys Leu Ser Ile Leu Glu Lys Glu Asp Glu Thr
        2755                2760                2765            
Glu Val Gln Glu Ser Lys Lys Ala Cys Met Phe Glu Pro Leu Pro Ile
    2770                2775                2780                
Lys Leu Ser Lys Ser Ile Ala Ser Gln Thr Asp Gly Thr Leu Lys Ile
2785                2790                2795                2800
Ser Ser Ser Asn Gln Thr Pro Gln Ile Leu Val Lys Asn Ala Gly Ile
                2805                2810                2815    
Gln Ile Asn Leu Gln Ser Glu Cys Ser Ser Glu Glu Val Thr Glu Ile
            2820                2825                2830        
Ile Ser Gln Phe Thr Glu Lys Ile Glu Lys Met Gln Glu Leu His Ala
        2835                2840                2845            
Ala Glu Ile Leu Asp Met Glu Ser Arg His Ile Ser Glu Thr Glu Thr
    2850                2855                2860                
Leu Lys Arg Glu His Tyr Val Ala Val Gln Leu Leu Lys Glu Glu Cys
2865                2870                2875                2880
Gly Thr Leu Lys Ala Val Ile Gln Cys Leu Arg Ser Lys Glu Gly Leu
                2885                2890                2895    
Leu Arg Ala Val His Asn Glu Gly Met Gln Val Leu Ser Leu Thr Glu
            2900                2905                2910        
Ser Pro Tyr Ser Asp Gly Glu Asp His Ser Ile Gln Gln Val Ser Glu
        2915                2920                2925            
Pro Trp Leu Glu Glu Arg Lys Ala Tyr Ile Asn Thr Ile Ser Ser Leu
    2930                2935                2940                
Lys Asp Leu Ile Thr Lys Met Gln Leu Gln Arg Glu Ala Glu Val Tyr
2945                2950                2955                2960
Asp Ser Ser Gln Ser His Glu Ser Phe Ser Asp Trp Arg Gly Glu Leu
                2965                2970                2975    
Leu Leu Ala Leu Gln Gln Val Phe Leu Glu Glu Arg Ser Val Leu Leu
            2980                2985                2990        
Ala Ala Phe Arg Thr Glu Leu Thr Ala Leu Gly Thr Thr Asp Ala Val
        2995                3000                3005            
Gly Leu Leu Asn Cys Leu Glu Gln Arg Ile Gln Glu Gln Gly Val Glu
    3010                3015                3020                
Tyr Gln Ala Ala Met Glu Cys Leu Gln Lys Ala Asp Arg Arg Ser Leu
3025                3030                3035                3040
Leu Ser Glu Ile Gln Ala Leu His Ala Gln Met Asn Gly Arg Lys Ile
                3045                3050                3055    
Thr Leu Lys Arg Glu Gln Glu Ser Glu Lys Pro Ser Gln Glu Leu Leu
            3060                3065                3070        
Glu Tyr Asn Ile Gln Gln Lys Gln Ser Gln Met Leu Glu Met Gln Val
        3075                3080                3085            
Glu Leu Ser Ser Met Lys Asp Arg Ala Thr Glu Leu Gln Glu Gln Leu
    3090                3095                3100                
Ser Ser Glu Lys Met Val Val Ala Glu Leu Lys Ser Glu Leu Ala Gln
3105                3110                3115                3120
Thr Lys Leu Glu Leu Glu Thr Thr Leu Lys Ala Gln His Lys His Leu
                3125                3130                3135    
Lys Glu Leu Glu Ala Phe Arg Leu Glu Val Lys Asp Lys Thr Asp Glu
            3140                3145                3150        
Val His Leu Leu Asn Asp Thr Leu Ala Ser Glu Gln Lys Lys Ser Arg
        3155                3160                3165            
Glu Leu Gln Trp Ala Leu Glu Lys Glu Lys Ala Lys Leu Gly Arg Ser
    3170                3175                3180                
Glu Glu Arg Asp Lys Glu Glu Leu Glu Asp Leu Lys Phe Ser Leu Glu
3185                3190                3195                3200
Ser Gln Lys Gln Arg Asn Leu Gln Leu Asn Leu Leu Leu Glu Gln Gln
                3205                3210                3215    
Lys Gln Leu Leu Asn Glu Ser Gln Gln Lys Ile Glu Ser Gln Arg Met
            3220                3225                3230        
Leu Tyr Asp Ala Gln Leu Ser Glu Glu Gln Gly Arg Asn Leu Glu Leu
        3235                3240                3245            
Gln Val Leu Leu Glu Ser Glu Lys Val Arg Ile Arg Glu Met Ser Ser
    3250                3255                3260                
Thr Leu Asp Arg Glu Arg Glu Leu His Ala Gln Leu Gln Ser Ser Asp
3265                3270                3275                3280
Gly Thr Gly Gln Ser Arg Pro Pro Leu Pro Ser Glu Asp Leu Leu Lys
                3285                3290                3295    
Glu Leu Gln Lys Gln Leu Glu Glu Lys His Ser Arg Ile Val Glu Leu
            3300                3305                3310        
Leu Asn Glu Thr Glu Lys Tyr Lys Leu Asp Ser Leu Gln Thr Arg Gln
        3315                3320                3325            
Gln Met Glu Lys Asp Arg Gln Val His Arg Lys Thr Leu Gln Thr Glu
    3330                3335                3340                
Gln Glu Ala Asn Thr Glu Gly Gln Lys Lys Met His Glu Leu Gln Ser
3345                3350                3355                3360
Lys Val Glu Asp Leu Gln Arg Gln Leu Glu Glu Lys Arg Gln Gln Val
                3365                3370                3375    
Tyr Lys Leu Asp Leu Glu Gly Gln Arg Leu Gln Gly Ile Met Gln Glu
            3380                3385                3390        
Phe Gln Lys Gln Glu Leu Glu Arg Glu Glu Lys Arg Glu Ser Arg Arg
        3395                3400                3405            
Ile Leu Tyr Gln Asn Leu Asn Glu Pro Thr Thr Trp Ser Leu Thr Ser
    3410                3415                3420                
Asp Arg Thr Arg Asn Trp Val Leu Gln Gln Lys Ile Glu Gly Glu Thr
3425                3430                3435                3440
Lys Glu Ser Asn Tyr Ala Lys Leu Ile Glu Met Asn Gly Gly Gly Thr
                3445                3450                3455    
Gly Cys Asn His Glu Leu Glu Met Ile Arg Gln Lys Leu Gln Cys Val
            3460                3465                3470        
Ala Ser Lys Leu Gln Val Leu Pro Gln Lys Ala Ser Glu Arg Leu Gln
        3475                3480                3485            
Phe Glu Thr Ala Asp Asp Glu Asp Phe Ile Trp Val Gln Glu Asn Ile
    3490                3495                3500                
Asp Glu Ile Ile Leu Gln Leu Gln Lys Leu Thr Gly Gln Gln Gly Glu
3505                3510                3515                3520
Glu Pro Ser Leu Val Ser Pro Ser Thr Ser Cys Gly Ser Leu Thr Glu
                3525                3530                3535    
Arg Leu Leu Arg Gln Asn Ala Glu Leu Thr Gly His Ile Ser Gln Leu
            3540                3545                3550        
Thr Glu Glu Lys Asn Asp Leu Arg Asn Met Val Met Lys Leu Glu Glu
        3555                3560                3565            
Gln Ile Arg Trp Tyr Arg Gln Thr Gly Ala Gly Arg Asp Asn Ser Ser
    3570                3575                3580                
Arg Phe Ser Leu Asn Gly Gly Ala Asn Ile Glu Ala Ile Ile Ala Ser
3585                3590                3595                3600
Glu Lys Glu Val Trp Asn Arg Glu Lys Leu Thr Leu Gln Lys Ser Leu
                3605                3610                3615    
Lys Arg Ala Glu Ala Glu Val Tyr Lys Leu Lys Ala Glu Leu Arg Asn
            3620                3625                3630        
Asp Ser Leu Leu Gln Thr Leu Ser Pro Asp Ser Glu His Val Thr Leu
        3635                3640                3645            
Lys Arg Ile Tyr Gly Lys Tyr Leu Arg Ala Glu Ser Phe Arg Lys Ala
    3650                3655                3660                
Leu Ile Tyr Gln Lys Lys Tyr Leu Leu Leu Leu Leu Gly Gly Phe Gln
3665                3670                3675                3680
Glu Cys Glu Asp Ala Thr Leu Ala Leu Leu Ala Arg Met Gly Gly Gln
                3685                3690                3695    
Pro Ala Phe Thr Asp Leu Glu Val Ile Thr Asn Arg Pro Lys Gly Phe
            3700                3705                3710        
Thr Arg Phe Arg Ser Ala Val Arg Val Ser Ile Ala Ile Ser Arg Met
        3715                3720                3725            
Lys Phe Leu Val Arg Arg Trp His Arg Val Thr Gly Ser Val Ser Ile
    3730                3735                3740                
Asn Ile Asn Arg Asp Gly Phe Gly Leu Asn Gln Gly Ala Glu Lys Thr
3745                3750                3755                3760
Asp Ser Phe Tyr His Ser Ser Gly Gly Leu Glu Leu Tyr Gly Glu Pro
                3765                3770                3775    
Arg His Thr Thr Tyr Arg Ser Arg Ser Asp Leu Asp Tyr Ile Arg Ser
            3780                3785                3790        
Pro Leu Pro Phe Gln Asn Arg Tyr Pro Gly Thr Pro Ala Asp Phe Asn
        3795                3800                3805            
Pro Gly Ser Leu Ala Cys Ser Gln Leu Gln Asn Tyr Asp Pro Asp Arg
    3810                3815                3820                
Ala Leu Thr Asp Tyr Ile Thr Arg Leu Glu Ala Leu Gln Arg Arg Leu
3825                3830                3835                3840
Gly Thr Ile Gln Ser Gly Ser Thr Thr Gln Phe His Ala Gly Met Arg
                3845                3850                3855    
Arg
    


<210> 8275
<211> 657
<212> PRT
<213> Homo sapiens

<400> 8275
Met Asp Glu Gln Glu Ala Leu Asn Ser Ile Met Asn Asp Leu Val Ala
 1               5                  10                  15      
Leu Gln Met Asn Arg Arg His Arg Met Pro Gly Tyr Glu Thr Met Lys
            20                  25                  30          
Asn Lys Asp Thr Gly His Ser Asn Arg Gln Lys Lys His Asn Ser Ser
        35                  40                  45              
Ser Ser Ala Leu Leu Asn Ser Pro Thr Val Thr Thr Ser Ser Cys Ala
    50                  55                  60                  
Gly Ala Ser Glu Lys Lys Lys Phe Leu Ser Asp Val Arg Ile Lys Phe
65                  70                  75                  80  
Glu His Asn Gly Glu Arg Arg Ile Ile Ala Phe Ser Arg Pro Val Lys
                85                  90                  95      
Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gln Pro Leu
            100                 105                 110         
Asp Leu His Tyr Met Asn Asn Glu Leu Ser Ile Leu Leu Lys Asn Gln
        115                 120                 125             
Asp Asp Leu Asp Lys Ala Ile Asp Ile Leu Asp Arg Ser Ser Ser Met
    130                 135                 140                 
Lys Ser Leu Arg Ile Leu Leu Leu Ser Gln Asp Arg Asn His Asn Ser
145                 150                 155                 160 
Ser Ser Pro His Ser Gly Val Ser Arg Gln Val Arg Ile Lys Ala Ser
                165                 170                 175     
Gln Ser Ala Gly Asp Ile Asn Thr Ile Tyr Gln Pro Pro Glu Pro Arg
            180                 185                 190         
Ser Arg His Leu Ser Val Ser Ser Gln Asn Pro Gly Arg Ser Ser Pro
        195                 200                 205             
Pro Pro Gly Tyr Val Pro Glu Arg Gln Gln His Ile Ala Arg Gln Gly
    210                 215                 220                 
Ser Tyr Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Thr Ser
225                 230                 235                 240 
Glu Gln Cys Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu Ser
                245                 250                 255     
Gly Ser Cys Gln Ser Leu Asp Arg Ser Ala Asp Ser Pro Ser Phe Arg
            260                 265                 270         
Lys Ser Arg Met Ser Arg Ala Gln Ser Phe Pro Asp Asn Arg Gln Glu
        275                 280                 285             
Tyr Ser Asp Arg Glu Thr Gln Leu Tyr Asp Lys Gly Val Lys Gly Gly
    290                 295                 300                 
Thr Tyr Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr Ser
305                 310                 315                 320 
Asp Gly Arg Arg Thr Phe Pro Arg Ile Arg Arg His Gln Gly Asn Leu
                325                 330                 335     
Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr Asn Gly Glu Asn
            340                 345                 350         
Met Gly Leu Ala Val Gln Tyr Leu Asp Pro Arg Gly Arg Leu Arg Ser
        355                 360                 365             
Ala Asp Ser Glu Asn Ala Leu Ser Val Gln Glu Arg Asn Val Pro Thr
    370                 375                 380                 
Lys Ser Pro Ser Ala Pro Ile Asn Trp Arg Arg Gly Lys Leu Leu Gly
385                 390                 395                 400 
Gln Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr Gly
                405                 410                 415     
Arg Glu Leu Ala Ser Lys Gln Val Gln Phe Asp Pro Asp Ser Pro Glu
            420                 425                 430         
Thr Ser Lys Glu Val Ser Ala Leu Glu Cys Glu Ile Gln Leu Leu Lys
        435                 440                 445             
Asn Leu Gln His Glu Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg Asp
    450                 455                 460                 
Arg Ala Glu Lys Thr Leu Thr Ile Phe Met Glu Tyr Met Pro Gly Gly
465                 470                 475                 480 
Ser Val Lys Asp Gln Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser Val
                485                 490                 495     
Thr Arg Lys Tyr Thr Arg Gln Ile Leu Glu Gly Met Ser Tyr Leu His
            500                 505                 510         
Ser Asn Met Ile Val His Arg Asp Ile Lys Gly Ala Asn Ile Leu Arg
        515                 520                 525             
Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys Arg
    530                 535                 540                 
Leu Gln Thr Ile Cys Met Ser Gly Thr Gly Met Arg Ser Val Thr Gly
545                 550                 555                 560 
Thr Pro Tyr Trp Met Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr Gly
                565                 570                 575     
Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr Val Val Glu Met Leu
            580                 585                 590         
Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala Ile Phe
        595                 600                 605             
Lys Ile Ala Thr Gln Pro Thr Asn Pro Gln Leu Pro Ser His Ile Ser
    610                 615                 620                 
Glu His Gly Arg Asp Phe Leu Arg Arg Ile Phe Val Glu Ala Arg Gln
625                 630                 635                 640 
Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe Ala Gln Leu Met
                645                 650                 655     
Tyr
    


<210> 8276
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8276
Met Ile Gln Thr Val Pro Asp Pro Ala Ala His Ile Lys Glu Ala Leu
 1               5                  10                  15      
Ser Val Val Ser Glu Asp Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr
            20                  25                  30          
Pro His Leu Ala Lys Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr
        35                  40                  45              
Gly Gln Thr Ser Lys Met Ser Pro Arg Val Pro Gln Gln Asp Trp Leu
    50                  55                  60                  
Ser Gln Pro Pro Ala Arg Val Thr Ile Lys Met Glu Cys Asn Pro Ser
65                  70                  75                  80  
Gln Val Asn Gly Ser Arg Asn Ser Pro Asp Glu Cys Ser Val Ala Lys
                85                  90                  95      
Gly Gly Lys Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly
            100                 105                 110         
Ser Tyr Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn
        115                 120                 125             
Glu Arg Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp
    130                 135                 140                 
His Val Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro
145                 150                 155                 160 
Asp Val Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys
                165                 170                 175     
Lys Met Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala
            180                 185                 190         
Asp Ile Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro
        195                 200                 205             
His Leu Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg
    210                 215                 220                 
Leu Met His Ala Arg Asn Thr Asp Leu Pro Tyr Glu Pro Pro Arg Arg
225                 230                 235                 240 
Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala Ala
                245                 250                 255     
Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro Gln
            260                 265                 270         
Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn
        275                 280                 285             
Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu
    290                 295                 300                 
Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly
305                 310                 315                 320 
Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu
                325                 330                 335     
Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu
            340                 345                 350         
Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg
        355                 360                 365             
Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro
    370                 375                 380                 
His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro Tyr
385                 390                 395                 400 
Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala Pro
                405                 410                 415     
His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala Pro
            420                 425                 430         
Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr Arg
        435                 440                 445             
Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr
    450                 455                 460         


<210> 8277
<211> 479
<212> PRT
<213> Homo sapiens

<400> 8277
Met Ala Ser Thr Ile Lys Glu Ala Leu Ser Val Val Ser Glu Asp Gln
 1               5                  10                  15      
Ser Leu Phe Glu Cys Ala Tyr Gly Thr Pro His Leu Ala Lys Thr Glu
            20                  25                  30          
Met Thr Ala Ser Ser Ser Ser Asp Tyr Gly Gln Thr Ser Lys Met Ser
        35                  40                  45              
Pro Arg Val Pro Gln Gln Asp Trp Leu Ser Gln Pro Pro Ala Arg Val
    50                  55                  60                  
Thr Ile Lys Met Glu Cys Asn Pro Ser Gln Val Asn Gly Ser Arg Asn
65                  70                  75                  80  
Ser Pro Asp Glu Cys Ser Val Ala Lys Gly Gly Lys Met Val Gly Ser
                85                  90                  95      
Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met Glu Glu Lys His
            100                 105                 110         
Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val Pro
        115                 120                 125             
Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg Gln Trp Leu Glu
    130                 135                 140                 
Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn Ile Leu Leu Phe
145                 150                 155                 160 
Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr Lys Asp Asp Phe
                165                 170                 175     
Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu Leu Ser His Leu
            180                 185                 190         
His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr Ser Asp Asp Val
        195                 200                 205             
Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His Ala Arg Asn Thr
    210                 215                 220                 
Gly Gly Ala Ala Phe Ile Phe Pro Asn Thr Ser Val Tyr Pro Glu Ala
225                 230                 235                 240 
Thr Gln Arg Ile Thr Thr Arg Pro Asp Leu Pro Tyr Glu Pro Pro Arg
                245                 250                 255     
Arg Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala
            260                 265                 270         
Ala Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro
        275                 280                 285             
Gln Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala
    290                 295                 300                 
Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu
305                 310                 315                 320 
Leu Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn
                325                 330                 335     
Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly
            340                 345                 350         
Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala
        355                 360                 365             
Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys
    370                 375                 380                 
Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln
385                 390                 395                 400 
Pro His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro
                405                 410                 415     
Tyr Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala
            420                 425                 430         
Pro His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala
        435                 440                 445             
Pro Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr
    450                 455                 460                 
Arg Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr
465                 470                 475                 


<210> 8278
<211> 363
<212> PRT
<213> Homo sapiens

<400> 8278
Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met
 1               5                  10                  15      
Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg
            20                  25                  30          
Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg
        35                  40                  45              
Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn
    50                  55                  60                  
Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr
65                  70                  75                  80  
Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu
                85                  90                  95      
Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr
            100                 105                 110         
Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His
        115                 120                 125             
Ala Arg Asn Thr Asp Leu Pro Tyr Glu Pro Pro Arg Arg Ser Ala Trp
    130                 135                 140                 
Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala Ala Gln Pro Ser
145                 150                 155                 160 
Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro Gln Leu Asp Pro
                165                 170                 175     
Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser
            180                 185                 190         
Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser
        195                 200                 205             
Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys
    210                 215                 220                 
Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser
225                 230                 235                 240 
Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr
                245                 250                 255     
Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr
            260                 265                 270         
Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro His Pro Pro
        275                 280                 285             
Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro Tyr Met Gly Ser
    290                 295                 300                 
Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala Pro His Pro Pro
305                 310                 315                 320 
Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala Pro Asn Pro Tyr
                325                 330                 335     
Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr Arg Leu Pro Thr
            340                 345                 350         
Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr
        355                 360             


<210> 8279
<211> 174
<212> PRT
<213> Homo sapiens

<400> 8279
Met Phe Leu Thr Val Lys Leu Leu Leu Gly Gln Arg Cys Ser Leu Lys
 1               5                  10                  15      
Val Ser Gly Gln Glu Ser Val Ala Thr Leu Lys Arg Leu Val Ser Arg
            20                  25                  30          
Arg Leu Lys Val Pro Glu Glu Gln Gln His Leu Leu Phe Arg Gly Gln
        35                  40                  45              
Leu Leu Glu Asp Asp Lys His Leu Ser Asp Tyr Cys Ile Gly Pro Asn
    50                  55                  60                  
Ala Ser Ile Asn Val Ile Met Gln Pro Leu Glu Lys Met Ala Leu Lys
65                  70                  75                  80  
Glu Ala His Gln Pro Gln Thr Gln Pro Leu Trp His Gln Leu Gly Leu
                85                  90                  95      
Val Leu Ala Lys His Phe Glu Pro Gln Asp Ala Lys Ala Val Leu Gln
            100                 105                 110         
Leu Leu Arg Gln Glu His Glu Glu Arg Leu Gln Lys Ile Ser Leu Glu
        115                 120                 125             
His Leu Glu Gln Leu Ala Gln Tyr Leu Leu Ala Glu Glu Pro His Val
    130                 135                 140                 
Glu Pro Ala Gly Glu Arg Glu Leu Glu Ala Lys Ala Arg Pro Gln Ser
145                 150                 155                 160 
Ser Cys Asp Met Glu Glu Lys Glu Glu Ala Ala Ala Asp Gln
                165                 170                 


<210> 8280
<211> 116
<212> PRT
<213> Homo sapiens

<400> 8280
Met Arg Gly Val Ala Glu Val Lys Glu Pro Cys Ser Leu Pro Met Leu
 1               5                  10                  15      
Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val Lys Asn
            20                  25                  30          
Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala Val Met
        35                  40                  45              
Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln Ala Ser
    50                  55                  60                  
Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu Met Thr
65                  70                  75                  80  
Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro Ala Leu
                85                  90                  95      
Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His Leu Lys
            100                 105                 110         
Asn Asn Ser Ser
        115     


<210> 8281
<211> 259
<212> PRT
<213> Homo sapiens

<400> 8281
Met Ser Lys Tyr Lys Leu Ile Met Leu Arg His Gly Glu Gly Ala Trp
 1               5                  10                  15      
Asn Lys Glu Asn Arg Phe Cys Ser Trp Val Asp Gln Lys Leu Asn Ser
            20                  25                  30          
Glu Gly Met Glu Glu Ala Arg Asn Cys Gly Lys Gln Leu Lys Ala Leu
        35                  40                  45              
Asn Phe Glu Phe Asp Leu Val Phe Thr Ser Val Leu Asn Arg Ser Ile
    50                  55                  60                  
His Thr Ala Trp Leu Ile Leu Glu Glu Leu Gly Gln Glu Trp Val Pro
65                  70                  75                  80  
Val Glu Ser Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Ile
                85                  90                  95      
Gly Leu Asn Arg Glu Gln Met Ala Leu Asn His Gly Glu Glu Gln Val
            100                 105                 110         
Arg Leu Trp Arg Arg Ser Tyr Asn Val Thr Pro Pro Pro Ile Glu Glu
        115                 120                 125             
Ser His Pro Tyr Tyr Gln Glu Ile Tyr Asn Asp Arg Arg Tyr Lys Val
    130                 135                 140                 
Cys Asp Val Pro Leu Asp Gln Leu Pro Arg Ser Glu Ser Leu Lys Asp
145                 150                 155                 160 
Val Leu Glu Arg Leu Leu Pro Tyr Trp Asn Glu Arg Ile Ala Pro Glu
                165                 170                 175     
Val Leu Arg Gly Lys Thr Ile Leu Ile Ser Ala His Gly Asn Ser Ser
            180                 185                 190         
Arg Ala Leu Leu Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile
        195                 200                 205             
Asn Ile Thr Leu Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu
    210                 215                 220                 
Asn Leu Arg Ala Val Gly Pro His Gln Phe Leu Gly Asp Gln Glu Ala
225                 230                 235                 240 
Ile Gln Ala Ala Ile Lys Lys Val Glu Asp Gln Gly Lys Val Lys Gln
                245                 250                 255     
Ala Lys Lys
            


<210> 8282
<211> 331
<212> PRT
<213> Homo sapiens

<400> 8282
Met Ala Lys Trp Gly Gln Gly Asp Pro Arg Trp Ile Val Glu Glu Arg
 1               5                  10                  15      
Glu Asp Gly Thr Asn Val Asn Asn Trp His Trp Thr Glu Arg Asp Ala
            20                  25                  30          
Thr Ile Trp Ser Lys Gly Lys Leu Arg Gly Leu Leu Val Gly Ile Ala
        35                  40                  45              
Met Glu Asn Glu Ala Gly Arg Cys Glu Ile Ser Glu Leu Lys Gln Val
    50                  55                  60                  
Glu Gly Glu Ala Ser Cys Asn Ser Arg Lys Gly Lys Leu Ile Phe Phe
65                  70                  75                  80  
Tyr Glu Trp Asn Ile Lys Leu Ala Trp Lys Gly Thr Val Lys Glu Ser
                85                  90                  95      
Gly Ala Lys His Lys Gly Leu Ile Glu Ile Pro Ser Leu Ser Glu Glu
            100                 105                 110         
Asn Glu Ile Asn Asp Thr Glu Val Asn Val Ser Lys Lys Lys Gly Asp
        115                 120                 125             
Gly Glu Ile Leu Lys Asp Leu Met Arg Thr Thr Gly Thr Ala Lys Val
    130                 135                 140                 
Arg Glu Ala Leu Gly Glu Tyr Leu Lys Ala Leu Lys Thr Glu Phe Thr
145                 150                 155                 160 
Thr Gly Met Ile Leu Pro Thr Lys Ala Val Ala Thr Gln Glu Leu Thr
                165                 170                 175     
Leu Gln Arg Lys Leu Asn Glu Asn Lys Leu Gln Ala Ser Pro Val Ala
            180                 185                 190         
Leu Gly Val Arg Ile Pro Thr Val Ala Leu His Leu Thr Glu Leu Phe
        195                 200                 205             
Asp Thr Thr Val Glu Gln Leu Tyr Ser Ile Phe Thr Val Lys Glu Leu
    210                 215                 220                 
Val Gln Lys Phe Ser Lys Ser Pro Ala Val Leu Glu Ala Glu Arg Gly
225                 230                 235                 240 
Gly Lys Phe Gln Met Phe Asp Gly Asn Ile Ser Gly Glu Tyr Val Glu
                245                 250                 255     
Leu Val Thr Asn Arg Lys Ile Ile Met Lys Trp Arg Cys Arg Asn Trp
            260                 265                 270         
Pro Glu Glu His Tyr Ala Thr Val Glu Leu Asn Phe Val Pro Ala Pro
        275                 280                 285             
Gly Gln Thr Glu Leu Gln Leu Asp Cys Lys Gly Val Pro Val Cys Lys
    290                 295                 300                 
Glu Glu Asn Met Lys Phe Cys Trp Gln Lys Gln His Phe Glu Glu Ile
305                 310                 315                 320 
Lys Gly Leu Leu Glu Leu Thr Ala Gln Asn Ala
                325                 330     


<210> 8283
<211> 1585
<212> PRT
<213> Homo sapiens

<400> 8283
Met Thr Leu Ser Thr Glu Glu Ser Ile Glu Val Phe Gly Asp Ile Asn
 1               5                  10                  15      
Leu Thr Leu Gly Met Leu Asn Lys Glu Asp Ile Val Asn Lys Glu Asp
            20                  25                  30          
Ile Tyr Ser His Leu Thr Ser Val Ile Gln Asn Thr Asp Ile Leu Asp
        35                  40                  45              
Asp Ala Ile Val Gln Arg Leu Ile Tyr Tyr Ala Ser Lys Asp Met Arg
    50                  55                  60                  
Asp Asn Asn Met Leu Arg Glu Ile Arg Met Leu Ala Gly Glu Val Leu
65                  70                  75                  80  
Val Ser Leu Ala Ala His Asp Phe Asn Ser Val Met Tyr Glu Val Gln
                85                  90                  95      
Ser Asn Phe Arg Ile Leu Glu Leu Pro Asp Glu Phe Val Val Leu Ala
            100                 105                 110         
Leu Ala Glu Leu Ala Thr Ser Tyr Val Ser Gln Ser Ile Pro Phe Met
        115                 120                 125             
Met Met Thr Leu Leu Thr Met Gln Thr Met Leu Arg Leu Ala Glu Asp
    130                 135                 140                 
Glu Arg Met Lys Gly Thr Phe Cys Ile Ala Leu Glu Lys Phe Ser Lys
145                 150                 155                 160 
Ala Ile Tyr Lys Tyr Val Asn His Trp Arg Asp Phe Pro Tyr Pro Arg
                165                 170                 175     
Leu Asp Ala Asn Arg Leu Ser Asp Lys Ile Phe Met Leu Phe Arg Tyr
            180                 185                 190         
Ile Met Glu Lys Trp Ala Pro Leu Ala Ser Pro Met Gln Thr Leu Ser
        195                 200                 205             
Ile Val Lys Ala His Gly Pro Thr Val Ser Leu Leu Leu His Arg Glu
    210                 215                 220                 
Asp Phe Arg Gly Tyr Ala Leu Gly Gln Val Pro Trp Leu Leu Asn Gln
225                 230                 235                 240 
Tyr Lys Asp Lys Glu Ile Asp Phe His Val Thr Gln Ser Leu Lys Gln
                245                 250                 255     
Ile Leu Thr Ala Ala Val Leu Tyr Asp Ile Gly Leu Pro Arg Ser Leu
            260                 265                 270         
Arg Arg Ser Ile Phe Ile Asn Leu Leu Gln Gln Ile Cys Arg Ala Pro
        275                 280                 285             
Glu Pro Pro Val Lys Glu Asn Glu Met Lys Ala Ser Ser Cys Phe Leu
    290                 295                 300                 
Ile Leu Ala His Ser Asn Pro Gly Glu Leu Met Glu Phe Phe Asp Glu
305                 310                 315                 320 
Gln Val Arg Ser Asn Asn Glu Ala Ile Arg Val Gly Ile Leu Thr Leu
                325                 330                 335     
Leu Arg Leu Ala Val Asn Ala Asp Glu Pro Arg Leu Arg Asp His Ile
            340                 345                 350         
Ile Ser Ile Glu Arg Thr Val Lys Ile Val Met Gly Asp Leu Ser Thr
        355                 360                 365             
Lys Val Arg Asn Ser Val Leu Leu Leu Ile Gln Thr Met Cys Glu Lys
    370                 375                 380                 
Ser Tyr Ile Glu Ala Arg Glu Gly Trp Pro Leu Ile Asp Tyr Val Phe
385                 390                 395                 400 
Ser Gln Phe Ala Thr Leu Asn Arg Asn Leu Glu Lys Pro Val Lys Thr
                405                 410                 415     
Asn Phe His Glu Asn Glu Lys Glu Glu Glu Ser Val Arg Glu Thr Ser
            420                 425                 430         
Leu Glu Val Leu Lys Thr Leu Asp Pro Leu Val Ile Gly Met Pro Gln
        435                 440                 445             
Val Leu Trp Pro Arg Ile Leu Thr Phe Val Val Pro Ala Glu Tyr Thr
    450                 455                 460                 
Glu Ala Leu Glu Pro Leu Phe Ser Ile Ile Arg Ile Leu Ile Met Ala
465                 470                 475                 480 
Glu Glu Lys Lys Gln His Ser Ala Lys Glu Ser Thr Ala Leu Val Ile
                485                 490                 495     
Ser Thr Gly Ala Val Lys Leu Pro Ser Pro Gln Gln Leu Leu Ala Arg
            500                 505                 510         
Leu Leu Val Ile Ser Met Pro Ala Ser Leu Gly Glu Leu His Gly Ala
        515                 520                 525             
Gly Ala Ile Gly Leu Leu Lys Ile Leu Pro Glu Ile Ile His Pro Lys
    530                 535                 540                 
Leu Val Asp Leu Trp Lys Thr Arg Leu Pro Glu Leu Leu Gln Pro Leu
545                 550                 555                 560 
Glu Gly Lys Asn Ile Ser Thr Val Leu Trp Glu Thr Met Leu Leu Gln
                565                 570                 575     
Leu Leu Lys Glu Ser Leu Trp Lys Ile Ser Asp Val Ala Trp Thr Ile
            580                 585                 590         
Gln Leu Thr Gln Asp Phe Lys Gln Gln Met Gly Ser Tyr Ser Asn Asn
        595                 600                 605             
Ser Thr Glu Lys Lys Phe Leu Trp Asn Ala Leu Gly Thr Thr Leu Ala
    610                 615                 620                 
Cys Cys Gln Asp Ser Asp Phe Val Asn Ser Gln Ile Lys Glu Phe Leu
625                 630                 635                 640 
Thr Ala Pro Asn Gln Leu Gly Asp Gln Arg Gln Gly Ile Thr Ser Ile
                645                 650                 655     
Leu Gly Tyr Cys Ala Glu Asn His Leu Asp Ile Val Leu Lys Val Leu
            660                 665                 670         
Lys Thr Phe Gln Asn Gln Glu Lys Phe Phe Met Asn Arg Cys Lys Ser
        675                 680                 685             
Leu Phe Ser Gly Lys Lys Ser Leu Thr Lys Thr Asp Val Met Val Ile
    690                 695                 700                 
Tyr Gly Ala Val Ala Leu His Ala Pro Lys Lys Gln Leu Leu Ser Arg
705                 710                 715                 720 
Leu Asn Gln Asp Ile Ile Ser Gln Val Leu Ser Leu His Gly Gln Cys
                725                 730                 735     
Ser Gln Val Leu Gly Met Ser Val Met Asn Lys Asp Met Asp Leu Gln
            740                 745                 750         
Met Ser Phe Thr Arg Ser Ile Thr Glu Ile Gly Ile Ala Val Gln Asp
        755                 760                 765             
Ala Glu Asp Gln Gly Phe Gln Phe Ser Tyr Lys Glu Met Leu Ile Gly
    770                 775                 780                 
Tyr Met Leu Asp Phe Ile Arg Asp Glu Pro Leu Asp Ser Leu Ala Ser
785                 790                 795                 800 
Pro Ile Arg Trp Lys Ala Leu Ile Ala Ile Arg Tyr Leu Ser Lys Leu
                805                 810                 815     
Lys Pro Gln Leu Ser Leu Gln Asp His Leu Asn Ile Leu Glu Glu Asn
            820                 825                 830         
Ile Arg Arg Leu Leu Pro Leu Pro Pro Leu Glu Asn Leu Lys Ser Glu
        835                 840                 845             
Gly Gln Thr Asp Lys Asp Lys Glu His Ile Gln Phe Leu Tyr Glu Arg
    850                 855                 860                 
Ser Met Asp Ala Leu Gly Lys Leu Leu Lys Thr Met Met Trp Asp Asn
865                 870                 875                 880 
Val Asn Ala Glu Asp Cys Gln Glu Met Phe Asn Leu Leu Gln Met Trp
                885                 890                 895     
Leu Val Ser Gln Lys Glu Trp Glu Arg Glu Arg Ala Phe Gln Ile Thr
            900                 905                 910         
Ala Lys Val Leu Thr Asn Asp Ile Glu Ala Pro Glu Asn Phe Lys Ile
        915                 920                 925             
Gly Ser Leu Leu Gly Leu Leu Ala Pro His Ser Cys Asp Thr Leu Pro
    930                 935                 940                 
Thr Ile Arg Gln Ala Ala Ala Ser Ser Thr Ile Gly Leu Phe Tyr Ile
945                 950                 955                 960 
Lys Gly Ile His Leu Glu Val Glu Arg Leu Gln Gly Leu Gln Glu Gly
                965                 970                 975     
Leu Glu Ser Asp Asp Val Gln Val Gln Ile Lys Ile Ser Ser Lys Ile
            980                 985                 990         
Ala Lys Ile Val Ser Lys Phe Ile Pro Asn Glu Glu Ile Leu Met Phe
        995                 1000                1005            
Leu Glu Glu Met Leu Asp Gly Leu Glu Ser Leu Asn Pro Thr Cys Thr
    1010                1015                1020                
Lys Ala Cys Gly Ile Trp Met Ile Thr Val Leu Lys Gln Gln Gly Ala
1025                1030                1035                1040
Ala Leu Glu Asp Gln Leu Leu Glu Ile Leu Gly Thr Ile Tyr His His
                1045                1050                1055    
Met Pro Val Leu Arg Gln Lys Glu Glu Ser Phe Gln Phe Ile Leu Glu
            1060                1065                1070        
Ala Ile Ser Gln Ile Ala Ser Phe His Met Asp Thr Val Val Val Asn
        1075                1080                1085            
Leu Leu Gln Lys Pro Leu Pro Phe Asp Arg Asp Thr Lys Thr Leu Trp
    1090                1095                1100                
Lys Ala Leu Ala Glu Lys Pro Ala Ser Ser Gly Lys Leu Leu Gln Ala
1105                1110                1115                1120
Leu Ile Asp Lys Leu Glu Thr Glu Leu Glu Asp Asp Ile Ala Arg Val
                1125                1130                1135    
Glu Ala Ile Ser Val Ala Cys Ala Met Tyr Glu Val Ile Ser Met Gly
            1140                1145                1150        
Thr Ser Val Thr Gly Leu Tyr Pro Glu Leu Phe Thr Leu Leu Leu Lys
        1155                1160                1165            
Leu Val Ser Cys Thr Leu Gly Gln Lys Met Pro Thr Cys Pro Trp Ser
    1170                1175                1180                
His Arg Arg His Val Met Gln Gln Gly Glu Gln Gln Gln Ile Pro Asp
1185                1190                1195                1200
Pro Cys Arg Leu Ser Thr Ala Thr Leu Lys Cys Leu Gln Ala Gln Ala
                1205                1210                1215    
Met Arg Glu Gly Leu Ala Lys Glu Ser Asp Glu Gly Asp Asn Leu Trp
            1220                1225                1230        
Thr Leu Leu Ser Ser Pro Ser Thr His His Ile Gly Val Cys Ser Leu
        1235                1240                1245            
Ala Arg Ser Met Ala Val Trp Gln His Gly Val Ile Leu Asp Ile Met
    1250                1255                1260                
Glu Gln Leu Leu Ser Ser Leu Thr Ser Ser Ser Glu Asn Tyr Arg Ile
1265                1270                1275                1280
Thr Gly Ala Ala Phe Phe Ser Glu Leu Met Lys Glu Pro Ile Leu Trp
                1285                1290                1295    
Lys His Gly Asn Leu Arg Asn Val Leu Ile Leu Met Asp Gln Ser Ala
            1300                1305                1310        
Trp Asp Ser Asn Ala Thr Leu Arg Gln Met Ala Ile Arg Gly Leu Gly
        1315                1320                1325            
Asn Thr Ala Ser Gly Ala Pro His Lys Val Lys Lys His Lys Gln Leu
    1330                1335                1340                
Met Leu Glu Ser Ile Ile Arg Gly Leu Tyr His Leu Ala Arg Thr Glu
1345                1350                1355                1360
Val Val Cys Glu Ser Leu Lys Ala Leu Lys Lys Ile Leu Glu Leu Leu
                1365                1370                1375    
Thr Asp Arg Asp Val Ser Phe Tyr Phe Lys Glu Ile Val Leu Gln Thr
            1380                1385                1390        
Arg Thr Phe Phe Glu Asp Glu Gln Asp Asp Val Arg Leu Thr Ala Ile
        1395                1400                1405            
Phe Leu Phe Glu Asp Leu Ala Pro Leu Thr Gly Arg Arg Trp Lys Ile
    1410                1415                1420                
Phe Phe Ala Glu Glu Ile Lys Lys Ser Leu Ile Ser Phe Leu Leu His
1425                1430                1435                1440
Leu Trp Asp Pro Asn Pro Lys Ile Gly Val Ala Cys Arg Asp Val Leu
                1445                1450                1455    
Met Val Cys Ile Pro Phe Leu Gly Leu Gln Glu Leu Tyr Gly Val Leu
            1460                1465                1470        
Asp Arg Leu Leu Asp Gln Asp Leu Pro Arg Ala Arg Asp Phe Tyr Arg
        1475                1480                1485            
Gln Phe Cys Val Lys Leu Ala Lys Lys Asn Gln Glu Ile Leu Trp Ile
    1490                1495                1500                
Leu His Thr His Ser Phe Thr Phe Phe Thr Ser Thr Trp Glu Val Ile
1505                1510                1515                1520
Arg Ser Ala Ala Val Lys Leu Thr Asp Ala Val Val Leu Asn Leu Thr
                1525                1530                1535    
Ser Gln Tyr Val Glu Leu Leu Asp Arg Glu Gln Leu Thr Thr Arg Leu
            1540                1545                1550        
Gln Ala Leu Arg Gln Asp Pro Cys Ile Ser Val Gln Arg Ala Ala Glu
        1555                1560                1565            
Ala Ala Leu Gln Thr Leu Leu Arg Arg Cys Lys Glu Thr Ser Ile Pro
    1570                1575                1580                
Leu
1585


<210> 8284
<211> 583
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 577
<223> Xaa = Any Amino Acid

<400> 8284
Met Arg Arg Ser Ser Arg Ser Glu Asp Ile Leu Glu Ile Asp Glu Arg
 1               5                  10                  15      
Lys Asp His Arg Gln Leu Ser Ser Cys Val Phe Ile Pro Leu Thr Phe
            20                  25                  30          
Arg Ser Phe Arg Gly Gln Gly Gln Pro Cys Val Leu Trp His Thr Gly
        35                  40                  45              
Cys Cys Ser Gly Leu Pro Glu Asp Ser Arg Ala Pro Pro Ser Cys Ile
    50                  55                  60                  
Thr Ser Ser Thr Val Ser Tyr Gly Trp Met Val Gln Val Pro Pro Gly
65                  70                  75                  80  
Leu His Val Thr Thr Pro Pro Pro Pro Leu Leu Pro Ser Leu Thr Phe
                85                  90                  95      
Leu His Lys Thr Pro Leu Glu Ser Phe Ala Thr Ala Ile His Gly Leu
            100                 105                 110         
Lys Val Gly His Leu Thr Asp Arg Val Ile Gln Arg Ser Lys Arg Met
        115                 120                 125             
Ile Leu Asp Thr Leu Gly Ala Gly Phe Leu Gly Thr Thr Thr Glu Val
    130                 135                 140                 
Phe His Ile Ala Ser Gln Tyr Ser Lys Ile Tyr Ser Ser Asn Ile Ser
145                 150                 155                 160 
Ser Thr Val Trp Gly Gln Pro Asp Ile Arg Leu Pro Pro Thr Tyr Ala
                165                 170                 175     
Ala Phe Val Asn Gly Val Ala Ile His Ser Met Asp Phe Asp Asp Thr
            180                 185                 190         
Trp His Pro Ala Thr His Pro Ser Gly Ala Val Leu Pro Val Leu Thr
        195                 200                 205             
Ala Leu Ala Glu Ala Leu Pro Arg Ser Pro Lys Phe Ser Gly Leu Asp
    210                 215                 220                 
Leu Leu Leu Ala Phe Asn Val Gly Ile Glu Val Gln Gly Arg Leu Leu
225                 230                 235                 240 
His Phe Ala Lys Glu Ala Asn Asp Met Pro Lys Arg Phe His Pro Pro
                245                 250                 255     
Ser Val Val Gly Thr Leu Gly Ser Ala Ala Ala Ala Ser Lys Phe Leu
            260                 265                 270         
Gly Leu Ser Ser Thr Lys Cys Arg Glu Ala Leu Ala Ile Ala Val Ser
        275                 280                 285             
His Ala Gly Ala Pro Met Ala Asn Ala Ala Thr Gln Thr Lys Pro Leu
    290                 295                 300                 
His Ile Gly Asn Ala Ala Lys His Gly Ile Glu Ala Ala Phe Leu Ala
305                 310                 315                 320 
Met Leu Gly Leu Gln Gly Asn Lys Gln Val Leu Asp Leu Glu Ala Gly
                325                 330                 335     
Phe Gly Ala Phe Tyr Ala Asn Tyr Ser Pro Lys Val Leu Pro Ser Ile
            340                 345                 350         
Ala Ser Tyr Ser Trp Leu Leu Asp Gln Gln Asp Val Ala Phe Lys Arg
        355                 360                 365             
Phe Pro Ala His Leu Ser Thr His Trp Val Ala Asp Ala Ala Ala Ser
    370                 375                 380                 
Val Arg Lys His Leu Val Ala Glu Arg Ala Leu Leu Pro Thr Asp Tyr
385                 390                 395                 400 
Ile Lys Arg Ile Val Leu Arg Ile Pro Asn Val Gln Tyr Val Asn Arg
                405                 410                 415     
Pro Phe Pro Val Ser Glu His Glu Ala Arg His Ser Phe Gln Tyr Val
            420                 425                 430         
Ala Cys Ala Met Leu Leu Asp Gly Gly Ile Thr Val Pro Ser Phe His
        435                 440                 445             
Glu Cys Gln Ile Asn Arg Pro Gln Val Arg Glu Leu Leu Ser Lys Val
    450                 455                 460                 
Glu Leu Glu Tyr Pro Pro Asp Asn Leu Pro Ser Phe Asn Ile Leu Tyr
465                 470                 475                 480 
Cys Glu Ile Ser Val Thr Leu Lys Asp Gly Ala Thr Phe Thr Asp Arg
                485                 490                 495     
Ser Asp Thr Phe Tyr Gly His Trp Arg Lys Pro Leu Ser Gln Glu Asp
            500                 505                 510         
Leu Glu Glu Lys Phe Arg Ala Asn Ala Ser Lys Met Leu Ser Trp Asp
        515                 520                 525             
Thr Val Glu Ser Leu Ile Lys Ile Val Lys Asn Leu Glu Asp Leu Glu
    530                 535                 540                 
Asp Cys Ser Val Leu Thr Thr Leu Leu Lys Gly Pro Ser Pro Pro Glu
545                 550                 555                 560 
Val Ala Ser Asn Ser Pro Ala Cys Asn Asn Ser Ile Thr Asn Leu Ser
                565                 570                 575     
Xaa Gly Leu Pro Thr Ser Lys
            580             


<210> 8285
<211> 1070
<212> PRT
<213> Homo sapiens

<400> 8285
Met Tyr Cys Cys Ser Ala Gln Asp Ser Lys Met Asp Tyr Lys Arg Arg
 1               5                  10                  15      
Phe Leu Leu Gly Gly Ser Lys Gln Lys Val Gln Gln His Gln Gln Tyr
            20                  25                  30          
Pro Met Pro Glu Leu Gly Arg Ala Leu Ser Ala Pro Leu Ala Ser Thr
        35                  40                  45              
Ala Thr Thr Ala Pro Leu Gly Ser Leu Thr Ala Ala Gly Ser Cys His
    50                  55                  60                  
His Ala Met Pro His Thr Thr Pro Ile Ala Asp Ile Gln Gln Gly Ile
65                  70                  75                  80  
Ser Lys Tyr Leu Asp Ala Leu Asn Val Phe Cys Arg Ala Ser Thr Phe
                85                  90                  95      
Leu Thr Asp Leu Phe Ser Thr Val Phe Arg Asn Ser His Tyr Ser Lys
            100                 105                 110         
Ala Ala Thr Gln Leu Lys Asp Val Gln Glu His Val Met Glu Val Ala
        115                 120                 125             
Ser Arg Leu Thr Ser Ala Ile Lys Pro Glu Ile Ala Lys Met Leu Met
    130                 135                 140                 
Glu Leu Ser Ala Gly Ala Ala Asn Phe Thr Asp Gln Lys Glu Phe Ser
145                 150                 155                 160 
Leu Gln Asp Ile Glu Val Leu Gly Arg Cys Phe Leu Thr Val Val Gln
                165                 170                 175     
Val His Phe Gln Phe Leu Thr His Ala Leu Gln Lys Val Gln Pro Val
            180                 185                 190         
Ala His Ser Cys Phe Ala Glu Val Ile Val Pro Glu Lys Lys Asn Ser
        195                 200                 205             
Gly Ser Gly Gly Gly Leu Ser Gly Met Gly His Thr Pro Glu Val Glu
    210                 215                 220                 
Glu Ala Val Arg Ser Trp Arg Gly Ala Ala Glu Ala Thr Ser Arg Leu
225                 230                 235                 240 
Arg Glu Arg Gly Cys Asp Gly Cys Leu Ala Gly Ile Glu Val Gln Gln
                245                 250                 255     
Leu Phe Cys Ser Gln Ser Ala Ala Ile Pro Glu His Gln Leu Lys Glu
            260                 265                 270         
Leu Asn Ile Lys Ile Asp Ser Ala Leu Gln Ala Tyr Lys Ile Ala Leu
        275                 280                 285             
Glu Ser Leu Gly His Cys Glu Tyr Ala Met Lys Ala Gly Phe His Leu
    290                 295                 300                 
Asn Pro Lys Ala Ile Glu Ala Ser Leu Gln Gly Cys Cys Ser Glu Ala
305                 310                 315                 320 
Glu Ala Gln Gln Thr Gly Arg Arg Gln Thr Pro Pro Gln Pro Met Gln
                325                 330                 335     
Cys Glu Leu Pro Thr Val Pro Val Gln Ile Gly Ser His Phe Leu Lys
            340                 345                 350         
Gly Val Ser Phe Asn Glu Ser Ala Ala Asp Asn Leu Lys Leu Lys Thr
        355                 360                 365             
His Thr Met Leu Gln Leu Met Lys Glu Ala Gly Cys Tyr Asn Gly Ile
    370                 375                 380                 
Thr Ser Arg Asp Asp Phe Pro Val Thr Glu Val Leu Asn Gln Val Cys
385                 390                 395                 400 
Pro Ser Thr Trp Arg Gly Ala Cys Lys Thr Ala Val Gln Leu Leu Phe
                405                 410                 415     
Gly Gln Ala Gly Leu Val Val Val Asp Thr Ala Gln Ile Glu Asn Lys
            420                 425                 430         
Glu Ala Tyr Ala Pro Gln Ile Ser Leu Glu Gly Ser Arg Ile Val Val
        435                 440                 445             
Gln Val Pro Ser Thr Trp Cys Leu Lys Glu Asp Pro Ala Thr Met Ser
    450                 455                 460                 
Leu Leu Gln Arg Ser Leu Asp Pro Glu Lys Thr Leu Gly Leu Val Asp
465                 470                 475                 480 
Val Leu Tyr Thr Ala Val Leu Asp Leu Asn Arg Trp Arg Ala Gly Arg
                485                 490                 495     
Glu Gln Ala Leu Pro Cys Ile Gln Ile Gln Leu Gln Arg Glu Ile Cys
            500                 505                 510         
Asp Phe Gly Asn Gln Ala Asp Leu Pro Ser Gly Asn Gly Asn Lys Ser
        515                 520                 525             
Ser Gly Gly Leu Gln Lys Thr Phe Ser Lys Leu Thr Ser Arg Phe Thr
    530                 535                 540                 
Lys Lys Ala Ser Cys Thr Ser Ser Ser Ser Ser Thr Asn Tyr Ser Ile
545                 550                 555                 560 
Gln Asn Thr Pro Ser Lys Asn Ile Phe Ile Ala Gly Cys Ser Glu Glu
                565                 570                 575     
Lys Ala Lys Met Pro Gly Asn Ile Asp Thr Arg Leu Gln Ser Ile Leu
            580                 585                 590         
Asn Ile Gly Asn Phe Pro Arg Thr Thr Asp Pro Ser Gln Ser Ala Gln
        595                 600                 605             
Asn Ser Ser Asn Thr Val Ala Asn Gly Phe Leu Met Glu Arg Arg Glu
    610                 615                 620                 
Asn Phe Leu His Gly Asp Asp Gly Lys Asp Glu Lys Gly Met Asn Leu
625                 630                 635                 640 
Pro Thr Asp Gln Glu Met Gln Glu Val Ile Asp Phe Leu Ser Gly Phe
                645                 650                 655     
Asn Met Gly Gln Ser His Gln Gly Ser Pro Leu Val Thr Arg His Asn
            660                 665                 670         
Ser Ala Ala Thr Ala Met Val Thr Glu Gln Lys Ala Gly Ala Met Gln
        675                 680                 685             
Pro Gln Gln Pro Ser Leu Pro Val Pro Pro Pro Pro Arg Ala Pro Gln
    690                 695                 700                 
Ala Gly Ala His Thr Pro Leu Thr Pro Gln Pro Gly Leu Ala Pro Gln
705                 710                 715                 720 
Gln Gln Ser Pro Lys Gln Gln Gln Pro Gln Val Gln Tyr Tyr Gln His
                725                 730                 735     
Leu Leu Gln Pro Ile Gly Pro Gln Gln Pro Pro Pro Gln Pro Arg Ala
            740                 745                 750         
Pro Gly Lys Trp Val His Gly Ser Ser Gln Gln Pro Ala Gln Ala Val
        755                 760                 765             
Gly Ala Gly Leu Ser Pro Leu Gly Gln Trp Pro Gly Ile Ser Asp Leu
    770                 775                 780                 
Ser Ser Asp Leu Tyr Ser Leu Gly Leu Val Ser Ser Tyr Met Asp Asn
785                 790                 795                 800 
Val Met Ser Glu Val Leu Gly Gln Lys Pro Gln Gly Pro Arg Asn Asn
                805                 810                 815     
Thr Trp Pro Asn Arg Asp Gln Ser Asp Gly Val Phe Gly Met Leu Gly
            820                 825                 830         
Glu Ile Leu Pro Phe Asp Pro Ala Val Gly Ser Asp Pro Glu Phe Ala
        835                 840                 845             
Arg Tyr Val Ala Gly Val Ser Gln Ala Met Gln Gln Lys Arg Gln Ala
    850                 855                 860                 
Gln His Gly Arg Arg Pro Gly Asn Pro Arg Gly Asn Trp Pro Pro Met
865                 870                 875                 880 
Asp Asp Ala His Arg Thr Trp Pro Phe Pro Glu Phe Phe Thr Glu Gly
                885                 890                 895     
Asp Gly Leu His Gly Gly Trp Ser Gly Ala Gln Gly Asp Ser Ala Ser
            900                 905                 910         
Ser Ser Asp Glu Thr Ser Ser Ala Asn Gly Asp Ser Leu Phe Ser Met
        915                 920                 925             
Phe Ser Gly Pro Asp Leu Val Ala Ala Val Lys Gln Arg Arg Lys His
    930                 935                 940                 
Ser Ser Gly Glu Gln Asp Thr Ser Thr Leu Pro Ser Pro Pro Leu Leu
945                 950                 955                 960 
Thr Thr Val Glu Asp Val Asn Gln Asp Asn Lys Thr Lys Thr Trp Pro
                965                 970                 975     
Pro Lys Ala Pro Trp Gln His Pro Ser Pro Leu Pro Ser Thr Leu Pro
            980                 985                 990         
Ser Pro Ser Ala Pro Leu Tyr Ala Val Thr Ser Pro Gly Ser Gln Trp
        995                 1000                1005            
Asn Asp Thr Met Gln Met Leu Gln Ser Pro Val Trp Ala Ala Thr Asn
    1010                1015                1020                
Asp Cys Ser Ala Ala Ala Phe Ser Tyr Val Gln Thr Pro Pro Gln Pro
1025                1030                1035                1040
Pro Pro Pro Pro Ala His Lys Ala Ala Pro Lys Gly Phe Lys Ala Phe
                1045                1050                1055    
Pro Gly Lys Gly Glu Arg Arg Pro Ala Tyr Leu Pro Gln Tyr
            1060                1065                1070


<210> 8286
<211> 1360
<212> PRT
<213> Homo sapiens

<400> 8286
Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala
 1               5                  10                  15      
Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly
            20                  25                  30          
Arg Ala Ala Ala Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly Asp Ala
        35                  40                  45              
Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala
    50                  55                  60                  
Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val
65                  70                  75                  80  
Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val
                85                  90                  95      
Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn
            100                 105                 110         
His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg
        115                 120                 125             
Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser
    130                 135                 140                 
Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln
145                 150                 155                 160 
Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met
                165                 170                 175     
Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu
            180                 185                 190         
Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met
        195                 200                 205             
Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu
    210                 215                 220                 
Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg
225                 230                 235                 240 
Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser
                245                 250                 255     
Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu
            260                 265                 270         
Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu
        275                 280                 285             
Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val
    290                 295                 300                 
Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro
305                 310                 315                 320 
Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr
                325                 330                 335     
Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val
            340                 345                 350         
Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu
        355                 360                 365             
Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg
    370                 375                 380                 
Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu
385                 390                 395                 400 
Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile
                405                 410                 415     
Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe
            420                 425                 430         
Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly
        435                 440                 445             
Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile
    450                 455                 460                 
Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val
465                 470                 475                 480 
Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys
                485                 490                 495     
Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu
            500                 505                 510         
Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu
        515                 520                 525             
Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu
    530                 535                 540                 
Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe
545                 550                 555                 560 
Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp
                565                 570                 575     
Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val
            580                 585                 590         
Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile
        595                 600                 605             
Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly
    610                 615                 620                 
Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu
625                 630                 635                 640 
Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro
                645                 650                 655     
Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr
            660                 665                 670         
Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val
        675                 680                 685             
Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala
    690                 695                 700                 
Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr
705                 710                 715                 720 
Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp
                725                 730                 735     
Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly
            740                 745                 750         
Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro
        755                 760                 765             
Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn
    770                 775                 780                 
His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val
785                 790                 795                 800 
Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro
                805                 810                 815     
Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu
            820                 825                 830         
Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr
        835                 840                 845             
Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly
    850                 855                 860                 
Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp
865                 870                 875                 880 
Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys
                885                 890                 895     
Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp
            900                 905                 910         
Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr
        915                 920                 925             
Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile
    930                 935                 940                 
Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn
945                 950                 955                 960 
Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg
                965                 970                 975     
Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu
            980                 985                 990         
Glu Tyr Glu Leu Lys Ser Thr Lys Lys Gly Cys Lys Arg Tyr Trp Thr
        995                 1000                1005            
Lys Thr Ile Glu Lys Lys Leu Ala Asn Leu Ile Asn Ala Glu Glu Arg
    1010                1015                1020                
Arg Asp Val Ser Leu Lys Asp Cys Met Arg Arg Leu Phe Tyr Asn Phe
1025                1030                1035                1040
Asp Lys Asn Tyr Lys Asp Trp Gln Ser Ala Val Glu Cys Ile Ala Val
                1045                1050                1055    
Leu Asp Val Leu Leu Cys Leu Ala Asn Tyr Ser Arg Gly Gly Asp Gly
            1060                1065                1070        
Pro Met Cys Arg Pro Val Ile Leu Leu Pro Glu Asp Thr Pro Pro Phe
        1075                1080                1085            
Leu Glu Leu Lys Gly Ser Arg His Pro Cys Ile Thr Lys Thr Phe Phe
    1090                1095                1100                
Gly Asp Asp Phe Ile Pro Asn Asp Ile Leu Ile Gly Cys Glu Glu Glu
1105                1110                1115                1120
Glu Gln Glu Asn Gly Lys Ala Tyr Cys Val Leu Val Thr Gly Pro Asn
                1125                1130                1135    
Met Gly Gly Lys Ser Thr Leu Met Arg Gln Ala Gly Leu Leu Ala Val
            1140                1145                1150        
Met Ala Gln Met Gly Cys Tyr Val Pro Ala Glu Val Cys Arg Leu Thr
        1155                1160                1165            
Pro Ile Asp Arg Val Phe Thr Arg Leu Gly Ala Ser Asp Arg Ile Met
    1170                1175                1180                
Ser Gly Glu Ser Thr Phe Phe Val Glu Leu Ser Glu Thr Ala Ser Ile
1185                1190                1195                1200
Leu Met His Ala Thr Ala His Ser Leu Val Leu Val Asp Glu Leu Gly
                1205                1210                1215    
Arg Gly Thr Ala Thr Phe Asp Gly Thr Ala Ile Ala Asn Ala Val Val
            1220                1225                1230        
Lys Glu Leu Ala Glu Thr Ile Lys Cys Arg Thr Leu Phe Ser Thr His
        1235                1240                1245            
Tyr His Ser Leu Val Glu Asp Tyr Ser Gln Asn Val Ala Val Arg Leu
    1250                1255                1260                
Gly His Met Ala Cys Met Val Glu Asn Glu Cys Glu Asp Pro Ser Gln
1265                1270                1275                1280
Glu Thr Ile Thr Phe Leu Tyr Lys Phe Ile Lys Gly Ala Cys Pro Lys
                1285                1290                1295    
Ser Tyr Gly Phe Asn Ala Ala Arg Leu Ala Asn Leu Pro Glu Glu Val
            1300                1305                1310        
Ile Gln Lys Gly His Arg Lys Ala Arg Glu Phe Glu Lys Met Asn Gln
        1315                1320                1325            
Ser Leu Arg Leu Phe Arg Glu Val Cys Leu Ala Ser Glu Arg Ser Thr
    1330                1335                1340                
Val Asp Ala Glu Ala Val His Lys Leu Leu Thr Leu Ile Lys Glu Leu
1345                1350                1355                1360


<210> 8287
<211> 1068
<212> PRT
<213> Homo sapiens

<400> 8287
Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala
 1               5                  10                  15      
Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly
            20                  25                  30          
Arg Ala Ala Ala Ala Pro Glu Ala Ser Pro Ser Pro Gly Gly Asp Ala
        35                  40                  45              
Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala
    50                  55                  60                  
Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val
65                  70                  75                  80  
Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val
                85                  90                  95      
Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn
            100                 105                 110         
His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg
        115                 120                 125             
Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser
    130                 135                 140                 
Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln
145                 150                 155                 160 
Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met
                165                 170                 175     
Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu
            180                 185                 190         
Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met
        195                 200                 205             
Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu
    210                 215                 220                 
Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg
225                 230                 235                 240 
Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser
                245                 250                 255     
Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu
            260                 265                 270         
Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu
        275                 280                 285             
Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val
    290                 295                 300                 
Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro
305                 310                 315                 320 
Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr
                325                 330                 335     
Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val
            340                 345                 350         
Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu
        355                 360                 365             
Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg
    370                 375                 380                 
Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu
385                 390                 395                 400 
Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile
                405                 410                 415     
Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe
            420                 425                 430         
Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly
        435                 440                 445             
Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile
    450                 455                 460                 
Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val
465                 470                 475                 480 
Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys
                485                 490                 495     
Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu
            500                 505                 510         
Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu
        515                 520                 525             
Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu
    530                 535                 540                 
Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe
545                 550                 555                 560 
Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp
                565                 570                 575     
Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val
            580                 585                 590         
Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile
        595                 600                 605             
Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly
    610                 615                 620                 
Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu
625                 630                 635                 640 
Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro
                645                 650                 655     
Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr
            660                 665                 670         
Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val
        675                 680                 685             
Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala
    690                 695                 700                 
Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr
705                 710                 715                 720 
Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp
                725                 730                 735     
Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly
            740                 745                 750         
Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro
        755                 760                 765             
Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn
    770                 775                 780                 
His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val
785                 790                 795                 800 
Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro
                805                 810                 815     
Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu
            820                 825                 830         
Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr
        835                 840                 845             
Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly
    850                 855                 860                 
Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp
865                 870                 875                 880 
Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys
                885                 890                 895     
Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp
            900                 905                 910         
Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr
        915                 920                 925             
Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile
    930                 935                 940                 
Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn
945                 950                 955                 960 
Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg
                965                 970                 975     
Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu
            980                 985                 990         
Glu Tyr Glu Leu Lys Ser Thr Lys Lys Gly Cys Lys Arg Tyr Trp Thr
        995                 1000                1005            
Lys Thr Ile Glu Lys Lys Leu Ala Asn Leu Ile Asn Ala Glu Glu Arg
    1010                1015                1020                
Arg Asp Val Ser Leu Lys Asp Cys Met Arg Arg Leu Phe Tyr Asn Phe
1025                1030                1035                1040
Asp Lys Asn Tyr Lys Asp Trp Gln Ser Ala Val Glu Cys Ile Ala Val
                1045                1050                1055    
Leu Gly Lys Thr Leu Asn Lys Leu Val Leu Arg Leu
            1060                1065            


<210> 8288
<211> 1360
<212> PRT
<213> Homo sapiens

<400> 8288
Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala
 1               5                  10                  15      
Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly
            20                  25                  30          
Arg Ala Ala Ala Ala Pro Glu Ala Ser Pro Ser Pro Gly Gly Asp Ala
        35                  40                  45              
Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala
    50                  55                  60                  
Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val
65                  70                  75                  80  
Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val
                85                  90                  95      
Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn
            100                 105                 110         
His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg
        115                 120                 125             
Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser
    130                 135                 140                 
Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln
145                 150                 155                 160 
Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met
                165                 170                 175     
Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu
            180                 185                 190         
Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met
        195                 200                 205             
Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu
    210                 215                 220                 
Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg
225                 230                 235                 240 
Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser
                245                 250                 255     
Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu
            260                 265                 270         
Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu
        275                 280                 285             
Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val
    290                 295                 300                 
Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro
305                 310                 315                 320 
Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr
                325                 330                 335     
Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val
            340                 345                 350         
Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu
        355                 360                 365             
Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg
    370                 375                 380                 
Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu
385                 390                 395                 400 
Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile
                405                 410                 415     
Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe
            420                 425                 430         
Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly
        435                 440                 445             
Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile
    450                 455                 460                 
Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val
465                 470                 475                 480 
Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys
                485                 490                 495     
Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu
            500                 505                 510         
Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu
        515                 520                 525             
Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu
    530                 535                 540                 
Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe
545                 550                 555                 560 
Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp
                565                 570                 575     
Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val
            580                 585                 590         
Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile
        595                 600                 605             
Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly
    610                 615                 620                 
Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu
625                 630                 635                 640 
Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro
                645                 650                 655     
Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr
            660                 665                 670         
Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val
        675                 680                 685             
Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala
    690                 695                 700                 
Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr
705                 710                 715                 720 
Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp
                725                 730                 735     
Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly
            740                 745                 750         
Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro
        755                 760                 765             
Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn
    770                 775                 780                 
His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val
785                 790                 795                 800 
Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro
                805                 810                 815     
Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu
            820                 825                 830         
Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr
        835                 840                 845             
Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly
    850                 855                 860                 
Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp
865                 870                 875                 880 
Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys
                885                 890                 895     
Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp
            900                 905                 910         
Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr
        915                 920                 925             
Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile
    930                 935                 940                 
Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn
945                 950                 955                 960 
Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg
                965                 970                 975     
Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu
            980                 985                 990         
Glu Tyr Glu Leu Lys Ser Thr Lys Lys Gly Cys Lys Arg Tyr Trp Thr
        995                 1000                1005            
Lys Thr Ile Glu Lys Lys Leu Ala Asn Leu Ile Asn Ala Glu Glu Arg
    1010                1015                1020                
Arg Asp Val Ser Leu Lys Asp Cys Met Arg Arg Leu Phe Tyr Asn Phe
1025                1030                1035                1040
Asp Lys Asn Tyr Lys Asp Trp Gln Ser Ala Val Glu Cys Ile Ala Val
                1045                1050                1055    
Leu Asp Val Leu Leu Cys Leu Ala Asn Tyr Ser Arg Gly Gly Asp Gly
            1060                1065                1070        
Pro Met Cys Arg Pro Val Ile Leu Leu Pro Glu Asp Thr Pro Pro Phe
        1075                1080                1085            
Leu Glu Leu Lys Gly Ser Arg His Pro Cys Ile Thr Lys Thr Phe Phe
    1090                1095                1100                
Gly Asp Asp Phe Ile Pro Asn Asp Ile Leu Ile Gly Cys Glu Glu Glu
1105                1110                1115                1120
Glu Gln Glu Asn Gly Lys Ala Tyr Cys Val Leu Val Thr Gly Pro Asn
                1125                1130                1135    
Met Gly Gly Lys Ser Thr Leu Met Arg Gln Ala Gly Leu Leu Ala Val
            1140                1145                1150        
Met Ala Gln Met Gly Cys Tyr Val Pro Ala Glu Val Cys Arg Leu Thr
        1155                1160                1165            
Pro Ile Asp Arg Val Phe Thr Arg Leu Gly Ala Ser Asp Arg Ile Met
    1170                1175                1180                
Ser Gly Glu Ser Thr Phe Phe Val Glu Leu Ser Glu Thr Ala Ser Ile
1185                1190                1195                1200
Leu Met His Ala Thr Ala His Ser Leu Val Leu Val Asp Glu Leu Gly
                1205                1210                1215    
Arg Gly Thr Ala Thr Phe Asp Gly Thr Ala Ile Ala Asn Ala Val Val
            1220                1225                1230        
Lys Glu Leu Ala Glu Thr Ile Lys Cys Arg Thr Leu Phe Ser Thr His
        1235                1240                1245            
Tyr His Ser Leu Val Glu Asp Tyr Ser Gln Asn Val Ala Val Arg Leu
    1250                1255                1260                
Gly His Met Ala Cys Met Val Glu Asn Glu Cys Glu Asp Pro Ser Gln
1265                1270                1275                1280
Glu Thr Ile Thr Phe Leu Tyr Lys Phe Ile Lys Gly Ala Cys Pro Lys
                1285                1290                1295    
Ser Tyr Gly Phe Asn Ala Ala Arg Leu Ala Asn Leu Pro Glu Glu Val
            1300                1305                1310        
Ile Gln Lys Gly His Arg Lys Ala Arg Glu Phe Glu Lys Met Asn Gln
        1315                1320                1325            
Ser Leu Arg Leu Phe Arg Glu Val Cys Leu Ala Ser Glu Arg Ser Thr
    1330                1335                1340                
Val Asp Ala Glu Ala Val His Lys Leu Leu Thr Leu Ile Lys Glu Leu
1345                1350                1355                1360


<210> 8289
<211> 372
<212> PRT
<213> Homo sapiens

<400> 8289
Met Ala Asn Ala Gly Ser His Asp Asn Gly Thr His Phe Phe Phe Thr
 1               5                  10                  15      
Leu Gly Arg Ala Asp Glu Leu Asn Asn Lys His Thr Ile Phe Gly Lys
            20                  25                  30          
Val Thr Gly Asp Thr Val Tyr Asn Met Leu Arg Leu Ser Glu Val Asp
        35                  40                  45              
Ile Asp Asp Asp Glu Arg Pro His Asn Pro His Lys Ile Lys Ser Cys
    50                  55                  60                  
Glu Val Leu Phe Asn Pro Phe Asp Asp Ile Ile Pro Arg Glu Ile Lys
65                  70                  75                  80  
Arg Leu Lys Lys Glu Lys Pro Glu Glu Glu Val Lys Lys Leu Lys Pro
                85                  90                  95      
Lys Gly Thr Lys Asn Phe Ser Leu Leu Ser Phe Gly Glu Glu Ala Glu
            100                 105                 110         
Glu Glu Glu Glu Glu Val Asn Arg Val Ser Gln Ser Met Lys Gly Lys
        115                 120                 125             
Ser Lys Ser Ser His Asp Leu Leu Lys Asp Asp Pro His Leu Ser Ser
    130                 135                 140                 
Val Pro Val Val Glu Ser Glu Lys Gly Asp Ala Pro Asp Leu Val Asp
145                 150                 155                 160 
Asp Gly Glu Asp Glu Ser Ala Glu His Asp Glu Tyr Ile Asp Gly Asp
                165                 170                 175     
Glu Lys Asn Leu Met Arg Glu Arg Ile Ala Lys Lys Leu Lys Lys Asp
            180                 185                 190         
Thr Ser Ala Asn Val Lys Ser Ala Gly Glu Gly Glu Val Glu Lys Lys
        195                 200                 205             
Ser Val Ser Arg Ser Glu Glu Leu Arg Lys Glu Ala Arg Gln Leu Lys
    210                 215                 220                 
Arg Glu Leu Leu Ala Ala Lys Gln Lys Lys Val Glu Asn Ala Ala Lys
225                 230                 235                 240 
Gln Ala Glu Lys Arg Ser Glu Glu Glu Glu Ala Pro Pro Asp Gly Ala
                245                 250                 255     
Val Ala Glu Tyr Arg Arg Glu Lys Gln Lys Tyr Glu Ala Leu Arg Lys
            260                 265                 270         
Gln Gln Ser Lys Lys Gly Thr Ser Arg Glu Asp Gln Thr Leu Ala Leu
        275                 280                 285             
Leu Asn Gln Phe Lys Ser Lys Leu Thr Gln Ala Ile Ala Glu Thr Pro
    290                 295                 300                 
Glu Asn Asp Ile Pro Glu Thr Glu Val Glu Asp Asp Glu Gly Trp Met
305                 310                 315                 320 
Ser His Val Leu Gln Phe Glu Asp Lys Ser Arg Lys Val Lys Asp Ala
                325                 330                 335     
Ser Met Gln Asp Ser Asp Thr Phe Glu Ile Tyr Asp Pro Arg Asn Pro
            340                 345                 350         
Val Asn Lys Arg Arg Arg Glu Glu Ser Lys Lys Leu Met Arg Glu Lys
        355                 360                 365             
Lys Glu Arg Arg
    370         


<210> 8290
<211> 1445
<212> PRT
<213> Homo sapiens

<400> 8290
Met Glu Glu Gly His Gly Leu Asp Leu Thr Tyr Ile Thr Glu Arg Ile
 1               5                  10                  15      
Ile Ala Val Ser Phe Pro Ala Gly Cys Ser Glu Glu Ser Tyr Pro His
            20                  25                  30          
Asn Leu Gln Glu Val Thr Arg Met Leu Lys Ser Lys His Gly Asp Asn
        35                  40                  45              
Tyr Leu Val Leu Asn Leu Ser Glu Lys Arg Tyr Asp Leu Thr Lys Leu
    50                  55                  60                  
Asn Pro Lys Ile Met Asp Val Gly Trp Pro Glu Leu His Ala Pro Pro
65                  70                  75                  80  
Leu Asp Lys Met Cys Thr Ile Cys Lys Ala Gln Glu Ser Trp Leu Asn
                85                  90                  95      
Ser Asn Leu Gln His Val Val Val Ile His Cys Arg Gly Gly Lys Gly
            100                 105                 110         
Arg Ile Gly Val Val Ile Ser Ser Tyr Met His Phe Thr Asn Val Ser
        115                 120                 125             
Ala Ser Ala Asp Gln Ala Leu Asp Arg Phe Ala Met Lys Lys Phe Tyr
    130                 135                 140                 
Asp Asp Lys Val Ser Ala Leu Met Gln Pro Ser Gln Lys Arg Tyr Val
145                 150                 155                 160 
Gln Phe Leu Ser Gly Leu Leu Ser Gly Ser Val Lys Met Asn Ala Ser
                165                 170                 175     
Pro Leu Phe Leu His Phe Val Ile Leu His Gly Thr Pro Asn Phe Asp
            180                 185                 190         
Thr Gly Gly Val Cys Arg Pro Phe Leu Lys Leu Tyr Gln Ala Met Gln
        195                 200                 205             
Pro Val Tyr Thr Ser Gly Ile Tyr Asn Val Gly Pro Glu Asn Pro Ser
    210                 215                 220                 
Arg Ile Cys Ile Val Ile Glu Pro Ala Gln Leu Leu Lys Gly Asp Val
225                 230                 235                 240 
Met Val Lys Cys Tyr His Lys Lys Tyr Arg Ser Ala Thr Arg Asp Val
                245                 250                 255     
Ile Phe Arg Leu Gln Phe His Thr Gly Ala Val Gln Gly Tyr Gly Leu
            260                 265                 270         
Val Phe Gly Lys Glu Asp Leu Asp Asn Ala Ser Lys Asp Asp Arg Phe
        275                 280                 285             
Pro Asp Tyr Gly Lys Val Glu Leu Val Phe Ser Ala Thr Pro Glu Lys
    290                 295                 300                 
Ile Gln Gly Ser Glu His Leu Tyr Asn Asp His Gly Val Ile Val Asp
305                 310                 315                 320 
Tyr Asn Thr Thr Asp Pro Leu Ile Arg Trp Asp Ser Tyr Glu Asn Leu
                325                 330                 335     
Ser Ala Asp Gly Glu Val Leu His Thr Gln Gly Pro Val Asp Gly Ser
            340                 345                 350         
Leu Tyr Ala Lys Val Arg Lys Lys Ser Ser Ser Asp Pro Gly Ile Pro
        355                 360                 365             
Gly Gly Pro Gln Ala Ile Pro Ala Thr Asn Ser Pro Asp His Ser Asp
    370                 375                 380                 
His Thr Leu Ser Val Ser Ser Asp Ser Gly His Ser Thr Ala Ser Ala
385                 390                 395                 400 
Arg Thr Asp Lys Thr Glu Glu Arg Leu Ala Pro Gly Thr Arg Arg Gly
                405                 410                 415     
Leu Ser Ala Gln Glu Lys Ala Glu Leu Asp Gln Leu Leu Ser Gly Phe
            420                 425                 430         
Gly Leu Glu Asp Pro Gly Ser Ser Leu Lys Glu Met Thr Asp Ala Arg
        435                 440                 445             
Ser Lys Tyr Ser Gly Thr Arg His Val Val Pro Ala Gln Val His Val
    450                 455                 460                 
Asn Gly Asp Ala Ala Leu Lys Asp Arg Glu Thr Asp Ile Leu Asp Asp
465                 470                 475                 480 
Glu Met Pro His His Asp Leu His Ser Val Asp Ser Leu Gly Thr Leu
                485                 490                 495     
Ser Ser Ser Glu Gly Pro Gln Ser Val His Leu Gly Pro Phe Thr Cys
            500                 505                 510         
His Lys Ser Ser Gln Asn Ser Leu Leu Ser Asp Gly Phe Gly Ser Asn
        515                 520                 525             
Val Gly Glu Asp Pro Gln Gly Thr Leu Val Pro Asp Leu Gly Leu Gly
    530                 535                 540                 
Met Asp Gly Pro Tyr Glu Arg Glu Arg Thr Phe Gly Ser Arg Glu Pro
545                 550                 555                 560 
Lys Gln Pro Gln Pro Leu Leu Arg Lys Pro Ser Val Ser Ala Gln Met
                565                 570                 575     
Gln Ala Tyr Gly Gln Ser Ser Tyr Ser Thr Gln Thr Trp Val Arg Gln
            580                 585                 590         
Gln Gln Met Val Val Ala His Gln Tyr Ser Phe Ala Pro Asp Gly Glu
        595                 600                 605             
Ala Arg Leu Val Ser Arg Cys Pro Ala Asp Asn Pro Gly Leu Val Gln
    610                 615                 620                 
Ala Gln Pro Arg Val Pro Leu Thr Pro Thr Arg Gly Thr Ser Ser Arg
625                 630                 635                 640 
Val Ala Val Gln Arg Gly Val Gly Ser Gly Pro His Pro Pro Asp Thr
                645                 650                 655     
Gln Gln Pro Ser Pro Ser Lys Ala Phe Lys Pro Arg Phe Pro Gly Asp
            660                 665                 670         
Gln Val Val Asn Gly Ala Gly Pro Glu Leu Ser Thr Gly Pro Ser Pro
        675                 680                 685             
Gly Ser Pro Thr Leu Asp Ile Asp Gln Ser Ile Glu Gln Leu Asn Arg
    690                 695                 700                 
Leu Ile Leu Glu Leu Asp Pro Thr Phe Glu Pro Ile Pro Thr His Met
705                 710                 715                 720 
Asn Ala Leu Gly Ser Gln Ala Asn Gly Ser Val Ser Pro Asp Ser Val
                725                 730                 735     
Gly Gly Gly Leu Arg Ala Ser Ser Arg Leu Pro Asp Thr Gly Glu Gly
            740                 745                 750         
Pro Ser Arg Ala Thr Gly Arg Gln Gly Ser Ser Ala Glu Gln Pro Leu
        755                 760                 765             
Gly Gly Arg Leu Arg Lys Leu Ser Leu Gly Gln Tyr Asp Asn Asp Ala
    770                 775                 780                 
Gly Gly Gln Leu Pro Phe Ser Lys Cys Ala Trp Gly Lys Ala Gly Val
785                 790                 795                 800 
Asp Tyr Ala Pro Asn Leu Pro Pro Phe Pro Ser Pro Ala Asp Val Lys
                805                 810                 815     
Glu Thr Met Thr Pro Gly Tyr Pro Gln Asp Leu Asp Ile Ile Asp Gly
            820                 825                 830         
Arg Ile Leu Ser Ser Lys Glu Ser Met Cys Ser Thr Pro Ala Phe Pro
        835                 840                 845             
Val Ser Pro Glu Thr Pro Tyr Val Lys Thr Ala Leu Arg His Pro Pro
    850                 855                 860                 
Phe Ser Pro Pro Glu Pro Pro Leu Ser Ser Pro Ala Ser Gln His Lys
865                 870                 875                 880 
Gly Gly Arg Glu Pro Arg Ser Cys Pro Glu Thr Leu Thr His Ala Val
                885                 890                 895     
Gly Met Ser Glu Ser Pro Ile Gly Pro Lys Ser Thr Met Leu Arg Ala
            900                 905                 910         
Asp Ala Ser Ser Thr Pro Ser Phe Gln Gln Ala Phe Ala Ser Ser Cys
        915                 920                 925             
Thr Ile Ser Ser Asn Gly Pro Gly Gln Arg Arg Glu Ser Ser Ser Ser
    930                 935                 940                 
Ala Glu Arg Gln Trp Val Glu Ser Ser Pro Lys Pro Met Val Ser Leu
945                 950                 955                 960 
Leu Gly Ser Gly Arg Pro Thr Gly Ser Pro Leu Ser Ala Glu Phe Ser
                965                 970                 975     
Gly Thr Arg Lys Asp Ser Pro Val Leu Ser Cys Phe Pro Pro Ser Glu
            980                 985                 990         
Leu Gln Ala Pro Phe His Ser His Glu Leu Ser Leu Ala Glu Pro Pro
        995                 1000                1005            
Asp Ser Leu Ala Pro Pro Ser Ser Gln Ala Phe Leu Gly Phe Gly Thr
    1010                1015                1020                
Ala Pro Val Gly Ser Gly Leu Pro Pro Glu Glu Asp Leu Gly Ala Leu
1025                1030                1035                1040
Leu Ala Asn Ser His Gly Ala Ser Pro Thr Pro Ser Ile Pro Leu Thr
                1045                1050                1055    
Ala Thr Gly Ala Ala Asp Asn Gly Phe Leu Ser His Asn Phe Leu Thr
            1060                1065                1070        
Val Ala Pro Gly His Ser Ser His His Ser Pro Gly Leu Gln Gly Gln
        1075                1080                1085            
Gly Val Thr Leu Pro Gly Gln Pro Pro Leu Pro Glu Lys Lys Arg Ala
    1090                1095                1100                
Ser Glu Gly Asp Arg Ser Leu Gly Ser Val Ser Pro Ser Ser Ser Gly
1105                1110                1115                1120
Phe Ser Ser Pro His Ser Gly Ser Thr Ile Ser Ile Pro Phe Pro Asn
                1125                1130                1135    
Val Leu Pro Asp Phe Ser Lys Ala Ser Glu Ala Ala Ser Pro Leu Pro
            1140                1145                1150        
Asp Ser Pro Gly Asp Lys Leu Val Ile Val Lys Phe Val Gln Asp Thr
        1155                1160                1165            
Ser Lys Phe Trp Tyr Lys Ala Asp Ile Ser Arg Glu Gln Ala Ile Ala
    1170                1175                1180                
Met Leu Lys Asp Lys Glu Pro Gly Ser Phe Ile Val Arg Asp Ser His
1185                1190                1195                1200
Ser Phe Arg Gly Ala Tyr Gly Leu Ala Met Lys Val Ala Thr Pro Pro
                1205                1210                1215    
Pro Ser Val Leu Gln Leu Asn Lys Lys Ala Gly Asp Leu Ala Asn Glu
            1220                1225                1230        
Leu Val Arg His Phe Leu Ile Glu Cys Thr Pro Lys Gly Val Arg Leu
        1235                1240                1245            
Lys Gly Cys Ser Asn Glu Pro Tyr Phe Gly Ser Leu Thr Ala Leu Val
    1250                1255                1260                
Cys Gln His Ser Ile Thr Pro Leu Ala Leu Pro Cys Lys Leu Leu Ile
1265                1270                1275                1280
Pro Glu Arg Asp Pro Leu Glu Glu Ile Ala Glu Ser Ser Pro Gln Thr
                1285                1290                1295    
Ala Ala Asn Ser Ala Ala Glu Leu Leu Lys Gln Gly Ala Ala Cys Asn
            1300                1305                1310        
Val Trp Tyr Leu Asn Ser Val Glu Met Glu Ser Leu Thr Gly His Gln
        1315                1320                1325            
Ala Ile Gln Lys Ala Leu Ser Ile Thr Leu Val Gln Glu Pro Pro Pro
    1330                1335                1340                
Val Ser Thr Val Val His Phe Lys Val Ser Ala Gln Gly Ile Thr Leu
1345                1350                1355                1360
Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Val Asn
                1365                1370                1375    
Ser Val Ile Phe Cys Ala Leu Asp Pro Gln Asp Arg Lys Trp Ile Lys
            1380                1385                1390        
Asp Gly Pro Ser Ser Lys Val Phe Gly Phe Val Ala Arg Lys Gln Gly
        1395                1400                1405            
Ser Ala Thr Asp Asn Val Cys His Leu Phe Ala Glu His Asp Pro Glu
    1410                1415                1420                
Gln Pro Ala Ser Ala Ile Val Asn Phe Val Ser Lys Val Met Ile Gly
1425                1430                1435                1440
Ser Pro Lys Lys Val
                1445


<210> 8291
<211> 1062
<212> PRT
<213> Homo sapiens

<400> 8291
Met Ala Ala Ala Pro Phe Leu Lys His Trp Arg Thr Thr Phe Glu Arg
 1               5                  10                  15      
Val Glu Lys Phe Val Ser Pro Ile Tyr Phe Thr Asp Cys Asn Leu Arg
            20                  25                  30          
Gly Arg Leu Phe Gly Ala Ser Cys Pro Val Ala Val Leu Ser Ser Phe
        35                  40                  45              
Leu Thr Pro Glu Arg Leu Pro Tyr Gln Glu Ala Val Gln Arg Asp Phe
    50                  55                  60                  
Arg Pro Ala Gln Val Gly Asp Ser Phe Gly Pro Thr Trp Trp Thr Cys
65                  70                  75                  80  
Trp Phe Arg Val Glu Leu Thr Ile Pro Glu Ala Trp Val Gly Gln Glu
                85                  90                  95      
Val His Leu Cys Trp Glu Ser Asp Gly Glu Gly Leu Val Trp Arg Asp
            100                 105                 110         
Gly Glu Pro Val Gln Gly Leu Thr Lys Glu Gly Glu Lys Thr Ser Tyr
        115                 120                 125             
Val Leu Thr Asp Arg Leu Gly Glu Arg Asp Pro Arg Ser Leu Thr Leu
    130                 135                 140                 
Tyr Val Glu Val Ala Cys Asn Gly Leu Leu Gly Ala Gly Lys Gly Ser
145                 150                 155                 160 
Met Ile Ala Ala Pro Asp Pro Glu Lys Ile Phe Gln Leu Ser Arg Ala
                165                 170                 175     
Glu Leu Ala Val Phe His Arg Asp Val His Met Leu Leu Val Asp Leu
            180                 185                 190         
Glu Leu Leu Leu Gly Ile Ala Lys Gly Leu Gly Lys Asp Asn Gln Arg
        195                 200                 205             
Ser Phe Gln Ala Leu Tyr Thr Ala Asn Gln Met Val Asn Val Cys Asp
    210                 215                 220                 
Pro Ala Gln Pro Glu Thr Phe Pro Val Ala Gln Ala Leu Ala Ser Arg
225                 230                 235                 240 
Phe Phe Gly Gln His Gly Gly Glu Ser Gln His Thr Ile His Ala Thr
                245                 250                 255     
Gly His Cys His Ile Asp Thr Ala Trp Leu Trp Pro Phe Lys Glu Thr
            260                 265                 270         
Val Arg Lys Cys Ala Arg Ser Trp Val Thr Ala Leu Gln Leu Met Glu
        275                 280                 285             
Arg Asn Pro Glu Phe Ile Phe Ala Cys Ser Gln Ala Gln Gln Leu Glu
    290                 295                 300                 
Trp Val Lys Ser Arg Tyr Pro Gly Leu Tyr Ser Arg Ile Gln Glu Phe
305                 310                 315                 320 
Ala Cys Arg Gly Gln Phe Val Pro Val Gly Gly Thr Trp Val Glu Met
                325                 330                 335     
Asp Gly Asn Leu Pro Ser Gly Glu Ala Met Val Arg Gln Phe Leu Gln
            340                 345                 350         
Gly Gln Asn Phe Phe Leu Gln Glu Phe Gly Lys Met Cys Ser Glu Phe
        355                 360                 365             
Trp Leu Pro Asp Thr Phe Gly Tyr Ser Ala Gln Leu Pro Gln Ile Met
    370                 375                 380                 
His Gly Cys Gly Ile Arg Arg Phe Leu Thr Gln Lys Leu Ser Trp Asn
385                 390                 395                 400 
Leu Val Asn Ser Phe Pro His His Thr Phe Phe Trp Glu Gly Leu Asp
                405                 410                 415     
Gly Ser Arg Val Leu Val His Phe Pro Pro Gly Asp Ser Tyr Gly Met
            420                 425                 430         
Gln Gly Ser Val Glu Glu Val Leu Lys Thr Val Ala Asn Asn Arg Asp
        435                 440                 445             
Lys Gly Arg Ala Asn His Ser Ala Phe Leu Phe Gly Phe Gly Asp Gly
    450                 455                 460                 
Gly Gly Gly Pro Thr Gln Thr Met Leu Asp Arg Leu Lys Arg Leu Ser
465                 470                 475                 480 
Asn Thr Asp Gly Leu Pro Arg Val Gln Leu Ser Ser Pro Arg Gln Leu
                485                 490                 495     
Phe Ser Ala Leu Glu Ser Asp Ser Glu Gln Leu Cys Thr Trp Val Gly
            500                 505                 510         
Glu Leu Phe Leu Glu Leu His Asn Gly Thr Tyr Thr Thr His Ala Gln
        515                 520                 525             
Ile Lys Lys Gly Asn Arg Glu Cys Glu Arg Ile Leu His Asp Val Glu
    530                 535                 540                 
Leu Leu Ser Ser Leu Ala Leu Ala Arg Ser Ala Gln Phe Leu Tyr Pro
545                 550                 555                 560 
Ala Ala Gln Leu Gln His Leu Trp Arg Leu Leu Leu Leu Asn Gln Phe
                565                 570                 575     
His Asp Val Val Thr Gly Ser Cys Ile Gln Met Val Ala Glu Glu Ala
            580                 585                 590         
Met Cys His Tyr Glu Asp Ile Arg Ser His Gly Asn Thr Leu Leu Ser
        595                 600                 605             
Ala Ala Ala Ala Ala Leu Cys Ala Gly Glu Pro Gly Pro Glu Gly Leu
    610                 615                 620                 
Leu Ile Val Asn Thr Leu Pro Trp Lys Arg Ile Glu Val Met Ala Leu
625                 630                 635                 640 
Pro Lys Pro Gly Gly Ala His Ser Leu Ala Leu Val Thr Val Pro Ser
                645                 650                 655     
Met Gly Tyr Ala Pro Val Pro Pro Pro Thr Ser Leu Gln Pro Leu Leu
            660                 665                 670         
Pro Gln Gln Pro Val Phe Val Val Gln Glu Thr Asp Gly Ser Val Thr
        675                 680                 685             
Leu Asp Asn Gly Ile Ile Arg Val Lys Leu Asp Pro Thr Gly Arg Leu
    690                 695                 700                 
Thr Ser Leu Val Leu Val Ala Ser Gly Arg Glu Ala Ile Ala Glu Gly
705                 710                 715                 720 
Ala Val Gly Asn Gln Phe Val Leu Phe Asp Asp Val Pro Leu Tyr Trp
                725                 730                 735     
Asp Ala Trp Asp Val Met Asp Tyr His Leu Glu Thr Arg Lys Pro Val
            740                 745                 750         
Leu Gly Gln Ala Gly Thr Leu Ala Val Gly Thr Glu Gly Gly Leu Arg
        755                 760                 765             
Gly Ser Ala Trp Phe Leu Leu Gln Ile Ser Pro Asn Ser Arg Leu Ser
    770                 775                 780                 
Gln Glu Val Val Leu Asp Val Gly Cys Pro Tyr Val Arg Phe His Thr
785                 790                 795                 800 
Glu Val His Trp His Glu Ala His Lys Phe Leu Lys Val Glu Phe Pro
                805                 810                 815     
Ala Arg Val Arg Ser Ser Gln Ala Thr Tyr Glu Ile Gln Phe Gly His
            820                 825                 830         
Leu Gln Arg Pro Thr His Tyr Asn Thr Ser Trp Asp Trp Ala Arg Phe
        835                 840                 845             
Glu Val Trp Ala His Arg Trp Met Asp Leu Ser Glu His Gly Phe Gly
    850                 855                 860                 
Leu Ala Leu Leu Asn Asp Cys Lys Tyr Gly Ala Ser Val Arg Gly Ser
865                 870                 875                 880 
Ile Leu Ser Leu Ser Leu Leu Arg Ala Pro Lys Ala Pro Asp Ala Thr
                885                 890                 895     
Ala Asp Thr Gly Arg His Glu Phe Thr Tyr Ala Leu Met Pro His Lys
            900                 905                 910         
Gly Ser Phe Gln Asp Ala Gly Val Ile Gln Ala Ala Tyr Ser Leu Asn
        915                 920                 925             
Phe Pro Leu Leu Ala Leu Pro Ala Pro Ser Pro Ala Pro Ala Thr Ser
    930                 935                 940                 
Trp Ser Ala Phe Ser Val Ser Ser Pro Ala Val Val Leu Glu Thr Val
945                 950                 955                 960 
Lys Gln Ala Glu Ser Ser Pro Gln Arg Arg Ser Leu Val Leu Arg Leu
                965                 970                 975     
Tyr Glu Ala His Gly Ser His Val Asp Cys Trp Leu His Leu Ser Leu
            980                 985                 990         
Pro Val Gln Glu Ala Ile Leu Cys Asp Leu Leu Glu Arg Pro Asp Pro
        995                 1000                1005            
Ala Gly His Leu Thr Ser Gly Gln Pro Pro Glu Ala His Leu Phe Ser
    1010                1015                1020                
Leu Pro Ser Ala Val Pro Val Ala Arg Ala Ser Ala Ser Ala Thr Leu
1025                1030                1035                1040
Ser Pro Trp Gly Trp Gly Phe Val Cys Arg Arg Leu Trp Gly Leu Leu
                1045                1050                1055    
Ile Ser Ala Ser Pro Ala
            1060        


<210> 8292
<211> 336
<212> PRT
<213> Homo sapiens

<400> 8292
Asn Ser Lys Gly Gln Ser Val Ser Ser Pro Pro Asn Asp Cys Asn Ile
 1               5                  10                  15      
Ser Pro Ala Arg Val Gln Asn Trp Thr Glu Asp Glu Met Glu Glu Leu
            20                  25                  30          
Thr Glu Val Gly Phe Arg Arg Trp Ile Ile Lys Asn Lys Thr Pro Ser
        35                  40                  45              
Lys Lys Lys Lys Lys Tyr Ala Glu Leu Lys Glu His Val Leu Ala Gln
    50                  55                  60                  
Cys Lys Gln Ala Lys Asn Leu Asp Lys Arg Phe Glu Glu Leu Leu Thr
65                  70                  75                  80  
Arg Ile Thr Ser Leu Glu Arg Asn Ile Asn Tyr Leu Met Glu Leu Lys
                85                  90                  95      
Ser Ile Ala Ile Val Leu His Glu Ala Gln Ser Ile Thr Leu Cys Glu
            100                 105                 110         
Val Glu Glu Arg Ile Ser Glu Phe Glu Asp His Leu Ala Asn Ile Arg
        115                 120                 125             
His Ala Asp Lys Ile Arg Glu Arg Met Lys Arg Asn Glu Gln Ser Leu
    130                 135                 140                 
Gln Glu Ile Trp Asp Phe Val Lys Lys Thr Lys Leu Arg Leu Ile Gly
145                 150                 155                 160 
Val Pro Glu Asp Asp Glu Glu His Gly Asn Lys Leu Glu Asn Thr Leu
                165                 170                 175     
Gln Asn Thr Ile Gln Glu Asn Phe Leu Asn Leu Ala Arg Gln Ala Asn
            180                 185                 190         
Met Gln Ile Gln Glu Ile Gln Arg Met Pro Leu Arg Tyr Pro Leu Arg
        195                 200                 205             
Arg Ser Thr Pro Arg His Ile Ile Ile Arg Phe Ser Lys Val Glu Ile
    210                 215                 220                 
Lys Glu Glu Asn Ile Lys Gly Ser Gln Arg Glu Gly Gln Val Thr Tyr
225                 230                 235                 240 
Ala Gly Lys Pro Ile Arg Leu Thr Ala Asp Leu Ser Ala Glu Thr Val
                245                 250                 255     
Gln Ala Arg Arg Lys Trp Gly Pro Ile Phe Asn Ile Leu Lys Arg Lys
            260                 265                 270         
Asp Phe Gln Pro Arg Ile Ser Tyr Pro Ala Lys Leu Ser Phe Ile Ser
        275                 280                 285             
Glu Gly Glu Ile Lys Ser Cys Thr Asp Lys Gln Met Leu Arg Asp Cys
    290                 295                 300                 
Val Thr Thr Arg Ser Ala Leu Gln Glu Leu Leu Lys Glu Ala Leu Asn
305                 310                 315                 320 
Met Glu Lys Lys Ile Trp Tyr Gln Pro Leu Gln Lys His Thr Lys Ile
                325                 330                 335     


<210> 8293
<211> 447
<212> PRT
<213> Homo sapiens

<400> 8293
Met Lys Pro Glu Ser Gly Leu Ile Gln Thr Pro Ser Pro Ser Gln His
 1               5                  10                  15      
Ser Val Leu Thr Cys Thr Thr Gly Leu Thr Thr Ser Gln Pro Ser Pro
            20                  25                  30          
Ala His Tyr Ser Tyr Pro Ile Gln Ala Ser Ser Thr Asn Ala Ser Leu
        35                  40                  45              
Ile Ser Thr Ser Ser Thr Ile Ala Asn Ile Pro Ala Ala Ala Val Ala
    50                  55                  60                  
Ser Ile Ser Asn Gln Asp Tyr Pro Thr Tyr Thr Ile Leu Gly Gln Asn
65                  70                  75                  80  
Gln Tyr Gln Ala Cys Tyr Pro Ser Ser Ser Phe Gly Val Thr Gly Gln
                85                  90                  95      
Thr Asn Ser Asp Ala Glu Ser Thr Thr Leu Ala Ala Thr Thr Tyr Gln
            100                 105                 110         
Ser Glu Lys Pro Ser Val Met Ala Pro Ala Pro Ala Ala Gln Lys Leu
        115                 120                 125             
Ser Ser Gly Asp Pro Ser Thr Ser Pro Ser Leu Ser Gln Thr Thr Pro
    130                 135                 140                 
Ser Lys Asp Thr Asp Asp Gln Ser Arg Lys Asn Met Asn Ser Lys Asn
145                 150                 155                 160 
Arg Gly Lys Lys Lys Ala Asp Ala Thr Ser Ser Gln Asp Ser Glu Leu
                165                 170                 175     
Glu Arg Val Phe Leu Trp Asp Leu Asp Glu Thr Ile Ile Ile Phe His
            180                 185                 190         
Ser Leu Leu Thr Gly Ser Tyr Ala Gln Lys Tyr Gly Lys Asp Pro Thr
        195                 200                 205             
Val Val Ile Gly Ser Gly Leu Thr Met Glu Lys Met Ile Phe Glu Val
    210                 215                 220                 
Ala Asp Thr His Leu Phe Ser Asn Asp Leu Lys Glu Cys Asp Gln Val
225                 230                 235                 240 
His Val Glu Asp Val Ala Pro Asn Asp Lys Gly Gln Asn Leu Asn Asn
                245                 250                 255     
Tyr Ser Phe Ser Thr Asn Gly Phe Ser Gly Ser Gly Gly Ser Gly Ser
            260                 265                 270         
His Gly Ser Ser Val Gly Val Gln Gly Gly Val Asp Trp Met Arg Lys
        275                 280                 285             
Leu Ala Phe Arg Tyr Arg Lys Val Arg Glu Ile Tyr Asp Lys His Lys
    290                 295                 300                 
Ser Asn Val Gly Gly Leu Leu Ser Pro Gln Arg Lys Glu Ala Leu Gln
305                 310                 315                 320 
Arg Leu Arg Ala Glu Ile Glu Val Leu Thr Asp Ser Trp Leu Gly Thr
                325                 330                 335     
Ala Leu Lys Ser Leu Leu Leu Ile Gln Ser Arg Lys Asn Cys Val Asn
            340                 345                 350         
Val Leu Ile Thr Thr Thr Gln Leu Val Pro Ala Leu Ala Lys Val Leu
        355                 360                 365             
Leu Tyr Gly Leu Gly Glu Ile Phe Pro Ile Glu Asn Ile Tyr Ser Ala
    370                 375                 380                 
Thr Lys Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Val Ser Arg Phe
385                 390                 395                 400 
Gly Lys Lys Val Thr Tyr Val Val Ile Gly Asp Gly Arg Asp Glu Glu
                405                 410                 415     
Ile Ala Ala Lys Gln His Asn Met Pro Phe Trp Arg Ile Thr Asn His
            420                 425                 430         
Gly Asp Leu Val Ser Leu His Gln Ala Leu Glu Leu Asp Phe Leu
        435                 440                 445         


<210> 8294
<211> 573
<212> PRT
<213> Homo sapiens

<400> 8294
Met Glu Glu Glu Gln Asp Leu Pro Glu Gln Pro Val Lys Lys Ala Lys
 1               5                  10                  15      
Met Gln Glu Ser Gly Glu Gln Thr Ile Ser Gln Val Ser Asn Pro Asp
            20                  25                  30          
Val Ser Asp Gln Lys Pro Glu Thr Ser Ser Leu Ala Ser Asn Leu Pro
        35                  40                  45              
Met Ser Glu Glu Ile Met Thr Cys Thr Asp Tyr Ile Pro Arg Ser Ser
    50                  55                  60                  
Asn Asp Tyr Thr Ser Gln Met Tyr Ser Ala Lys Pro Tyr Ala His Ile
65                  70                  75                  80  
Leu Ser Val Pro Val Ser Glu Thr Ala Tyr Pro Gly Gln Thr Gln Tyr
                85                  90                  95      
Gln Thr Leu Gln Gln Thr Gln Pro Asp Ala Val Tyr Pro Gln Ala Thr
            100                 105                 110         
Gln Thr Tyr Gly Leu Pro Pro Phe Gly Ala Leu Trp Pro Gly Met Lys
        115                 120                 125             
Pro Glu Ser Gly Leu Ile Gln Thr Pro Ser Pro Ser Gln His Ser Val
    130                 135                 140                 
Leu Thr Cys Thr Thr Gly Leu Thr Thr Ser Gln Pro Ser Pro Ala His
145                 150                 155                 160 
Tyr Ser Tyr Pro Ile Gln Ala Ser Ser Thr Asn Ala Ser Leu Ile Ser
                165                 170                 175     
Thr Ser Ser Thr Ile Ala Asn Ile Pro Ala Ala Ala Val Ala Ser Ile
            180                 185                 190         
Ser Asn Gln Asp Tyr Pro Thr Tyr Thr Ile Leu Gly Gln Asn Gln Tyr
        195                 200                 205             
Gln Ala Cys Tyr Pro Ser Ser Ser Phe Gly Val Thr Gly Gln Thr Asn
    210                 215                 220                 
Ser Asp Ala Glu Ser Thr Thr Leu Ala Ala Thr Thr Tyr Gln Ser Glu
225                 230                 235                 240 
Lys Pro Ser Val Met Ala Pro Ala Pro Ala Ala Gln Lys Leu Ser Ser
                245                 250                 255     
Gly Asp Pro Ser Thr Ser Pro Ser Leu Ser Gln Thr Thr Pro Ser Lys
            260                 265                 270         
Asp Thr Asp Asp Gln Ser Arg Lys Asn Met Asn Ser Lys Asn Arg Gly
        275                 280                 285             
Lys Lys Lys Ala Asp Ala Thr Ser Ser Gln Asp Ser Glu Leu Glu Arg
    290                 295                 300                 
Val Phe Leu Trp Asp Leu Asp Glu Thr Ile Ile Ile Phe His Ser Leu
305                 310                 315                 320 
Leu Thr Gly Ser Tyr Ala Gln Lys Tyr Gly Lys Asp Pro Thr Val Val
                325                 330                 335     
Ile Gly Ser Gly Leu Thr Met Glu Lys Met Ile Phe Glu Val Ala Asp
            340                 345                 350         
Thr His Leu Phe Ser Asn Asp Leu Lys Glu Cys Asp Gln Val His Val
        355                 360                 365             
Glu Asp Val Ala Pro Asn Asp Lys Gly Gln Asn Leu Asn Asn Tyr Ser
    370                 375                 380                 
Phe Ser Thr Asn Gly Phe Ser Gly Ser Gly Gly Ser Gly Ser His Gly
385                 390                 395                 400 
Ser Ser Val Gly Val Gln Gly Gly Val Asp Trp Met Arg Lys Leu Ala
                405                 410                 415     
Phe Arg Tyr Arg Lys Val Arg Glu Ile Tyr Asp Lys His Lys Ser Asn
            420                 425                 430         
Val Gly Gly Leu Leu Ser Pro Gln Arg Lys Glu Ala Leu Gln Arg Leu
        435                 440                 445             
Arg Ala Glu Ile Glu Val Leu Thr Asp Ser Trp Leu Gly Thr Ala Leu
    450                 455                 460                 
Lys Ser Leu Leu Leu Ile Gln Ser Arg Lys Asn Cys Val Asn Val Leu
465                 470                 475                 480 
Ile Thr Thr Thr Gln Leu Val Pro Ala Leu Ala Lys Val Leu Leu Tyr
                485                 490                 495     
Gly Leu Gly Glu Ile Phe Pro Ile Glu Asn Ile Tyr Ser Ala Thr Lys
            500                 505                 510         
Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Val Ser Arg Phe Gly Lys
        515                 520                 525             
Lys Val Thr Tyr Val Val Ile Gly Asp Gly Arg Asp Glu Glu Ile Ala
    530                 535                 540                 
Ala Lys Gln His Asn Met Pro Phe Trp Arg Ile Thr Asn His Gly Asp
545                 550                 555                 560 
Leu Val Ser Leu His Gln Ala Leu Glu Leu Asp Phe Leu
                565                 570             


<210> 8295
<211> 1531
<212> PRT
<213> Homo sapiens

<400> 8295
Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu
 1               5                  10                  15      
Ser Pro Lys Ser Leu Tyr Ser Arg Glu Ser Val Tyr Asp Leu Leu Pro
            20                  25                  30          
Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala Ser Met
        35                  40                  45              
Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala Val Val
    50                  55                  60                  
Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly Gly Ala
65                  70                  75                  80  
Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser Thr Ser
                85                  90                  95      
Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser Ala Val
            100                 105                 110         
Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser Asn Thr
        115                 120                 125             
Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu Tyr Ile
    130                 135                 140                 
Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser Cys Gln
145                 150                 155                 160 
Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met Trp Met
                165                 170                 175     
Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser Tyr Asn
            180                 185                 190         
Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro Lys Gln
        195                 200                 205             
Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met Asp Ile
    210                 215                 220                 
Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser Gln Leu
225                 230                 235                 240 
Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr Leu Glu
                245                 250                 255     
Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys Gly Gln
            260                 265                 270         
Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val Gln Pro
        275                 280                 285             
Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg Gly Ser
    290                 295                 300                 
Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu Glu Gly
305                 310                 315                 320 
His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp Ser Gly
                325                 330                 335     
Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr Gly Arg
            340                 345                 350         
Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr Val Ile
        355                 360                 365             
Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val Asp Cys
    370                 375                 380                 
Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg Ile Gly
385                 390                 395                 400 
Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val Phe Arg
                405                 410                 415     
Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln Thr Pro
            420                 425                 430         
Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu Ile Leu
        435                 440                 445             
Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu Val Phe
    450                 455                 460                 
Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe Gln Glu
465                 470                 475                 480 
Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile Asp Met
                485                 490                 495     
Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro Tyr His
            500                 505                 510         
Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val Val Thr
        515                 520                 525             
Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr Pro Asp
    530                 535                 540                 
Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu Ile Ser
545                 550                 555                 560 
Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala Met Lys
                565                 570                 575     
Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn Ala Leu
            580                 585                 590         
Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp Val Thr
        595                 600                 605             
Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe Lys Thr
    610                 615                 620                 
Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile Ser Asn
625                 630                 635                 640 
Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His Leu Pro
                645                 650                 655     
Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr Asn Pro
            660                 665                 670         
Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro Gly Thr
        675                 680                 685             
Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp Ala Leu
    690                 695                 700                 
Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser Arg Glu
705                 710                 715                 720 
Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu Thr Glu
                725                 730                 735     
Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala Gln Thr
            740                 745                 750         
Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn Ser Val
        755                 760                 765             
Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser Phe Thr
    770                 775                 780                 
Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val Gln Gln
785                 790                 795                 800 
Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser Ala Pro
                805                 810                 815     
Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile Phe Gln
            820                 825                 830         
Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe Ser Ser
        835                 840                 845             
Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro Gly Arg
    850                 855                 860                 
Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn Gln Gln
865                 870                 875                 880 
Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala Ala Met
                885                 890                 895     
Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln Ile Gln
            900                 905                 910         
Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu Gln Gln
        915                 920                 925             
Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu Ser Thr
    930                 935                 940                 
Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro Pro Ala
945                 950                 955                 960 
Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val Ala Thr
                965                 970                 975     
Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly Asp Gly Glu Glu
            980                 985                 990         
Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val Phe Gln Thr Met
        995                 1000                1005            
Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln Val Asn Leu Phe
    1010                1015                1020                
Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser Gly Thr Gln Gln
1025                1030                1035                1040
Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met Met Ser Leu Gln
                1045                1050                1055    
Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln Ala Gln Leu Phe
            1060                1065                1070        
His Pro Gln Asn Pro Ile Ala Asp Ala Gln Asn Leu Ser Gln Glu Thr
        1075                1080                1085            
Gln Gly Ser Leu Phe His Ser Pro Asn Pro Ile Val His Ser Gln Thr
    1090                1095                1100                
Ser Thr Thr Ser Ser Glu Gln Met Gln Pro Pro Met Phe His Ser Gln
1105                1110                1115                1120
Ser Thr Ile Ala Val Leu Gln Gly Ser Ser Val Pro Gln Asp Gln Gln
                1125                1130                1135    
Ser Thr Asn Ile Phe Leu Ser Gln Ser Pro Met Asn Asn Leu Gln Thr
            1140                1145                1150        
Asn Thr Val Ala Gln Glu Ala Phe Phe Ala Ala Pro Asn Ser Ile Ser
        1155                1160                1165            
Pro Leu Gln Ser Thr Ser Asn Ser Glu Gln Gln Ala Ala Phe Gln Gln
    1170                1175                1180                
Gln Ala Pro Ile Ser His Ile Gln Thr Pro Met Leu Ser Gln Glu Gln
1185                1190                1195                1200
Ala Gln Pro Pro Gln Gln Gly Leu Phe Gln Pro Gln Val Ala Leu Gly
                1205                1210                1215    
Ser Leu Pro Pro Asn Pro Met Pro Gln Ser Gln Gln Gly Thr Met Phe
            1220                1225                1230        
Gln Ser Gln His Ser Ile Val Ala Met Gln Ser Asn Ser Pro Ser Gln
        1235                1240                1245            
Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260                
Gln Gln Ser Ile Leu Phe Ser Asn Gln Asn Thr Met Ala Thr Met Ala
1265                1270                1275                1280
Ser Pro Lys Gln Pro Pro Pro Asn Met Ile Phe Asn Pro Asn Gln Asn
                1285                1290                1295    
Pro Met Ala Asn Gln Glu Gln Gln Asn Gln Ser Ile Phe His Gln Gln
            1300                1305                1310        
Ser Asn Met Ala Pro Met Asn Gln Glu Gln Gln Pro Met Gln Phe Gln
        1315                1320                1325            
Ser Gln Ser Thr Val Ser Ser Leu Gln Asn Pro Gly Pro Thr Gln Ser
    1330                1335                1340                
Glu Ser Ser Gln Thr Pro Leu Phe His Ser Ser Pro Gln Ile Gln Leu
1345                1350                1355                1360
Val Gln Gly Ser Pro Ser Ser Gln Glu Gln Gln Val Thr Leu Phe Leu
                1365                1370                1375    
Ser Pro Ala Ser Met Ser Ala Leu Gln Thr Ser Ile Asn Gln Gln Asp
            1380                1385                1390        
Met Gln Gln Ser Pro Leu Tyr Ser Pro Gln Asn Asn Met Pro Gly Ile
        1395                1400                1405            
Gln Gly Ala Thr Ser Ser Pro Gln Pro Gln Ala Thr Leu Phe His Asn
    1410                1415                1420                
Thr Ala Gly Gly Thr Met Asn Gln Leu Gln Asn Ser Pro Gly Ser Ser
1425                1430                1435                1440
Gln Gln Thr Ser Gly Met Phe Leu Phe Gly Ile Gln Asn Asn Cys Ser
                1445                1450                1455    
Gln Leu Leu Thr Ser Gly Pro Ala Thr Leu Pro Asp Gln Leu Met Ala
            1460                1465                1470        
Ile Ser Gln Pro Gly Gln Pro Gln Asn Glu Gly Gln Pro Pro Val Thr
        1475                1480                1485            
Thr Leu Leu Ser Gln Gln Met Pro Glu Asn Ser Pro Leu Ala Ser Ser
    1490                1495                1500                
Ile Asn Thr Asn Gln Asn Ile Glu Lys Ile Asp Leu Leu Val Ser Leu
1505                1510                1515                1520
Gln Asn Gln Gly Asn Asn Leu Thr Gly Ser Phe
                1525                1530    


<210> 8296
<211> 1455
<212> PRT
<213> Homo sapiens

<400> 8296
Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile
 1               5                  10                  15      
Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys
            20                  25                  30          
Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu
        35                  40                  45              
Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr
    50                  55                  60                  
Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg
65                  70                  75                  80  
Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys
                85                  90                  95      
Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr
            100                 105                 110         
Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg
        115                 120                 125             
Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser
    130                 135                 140                 
Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val
145                 150                 155                 160 
Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn
                165                 170                 175     
Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met
            180                 185                 190         
Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile
        195                 200                 205             
Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly
    210                 215                 220                 
Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val
225                 230                 235                 240 
Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly
                245                 250                 255     
Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg
            260                 265                 270         
Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly
        275                 280                 285             
Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu
    290                 295                 300                 
Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu
305                 310                 315                 320 
Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg
                325                 330                 335     
Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr
            340                 345                 350         
Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val
        355                 360                 365             
Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu
    370                 375                 380                 
Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val
385                 390                 395                 400 
Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala
                405                 410                 415     
Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val
            420                 425                 430         
Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile
        435                 440                 445             
Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr
    450                 455                 460                 
Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys
465                 470                 475                 480 
Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met
                485                 490                 495     
Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile
            500                 505                 510         
Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser
        515                 520                 525             
Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr
    530                 535                 540                 
Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu
545                 550                 555                 560 
Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser
                565                 570                 575     
Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys
            580                 585                 590         
Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser
        595                 600                 605             
Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn
    610                 615                 620                 
Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr
625                 630                 635                 640 
Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser
                645                 650                 655     
Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu
            660                 665                 670         
Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser
        675                 680                 685             
Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala
    690                 695                 700                 
Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp
705                 710                 715                 720 
Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu
                725                 730                 735     
Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala
            740                 745                 750         
Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly
        755                 760                 765             
Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu
    770                 775                 780                 
Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu
785                 790                 795                 800 
Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser
                805                 810                 815     
Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala
            820                 825                 830         
Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly
        835                 840                 845             
Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser
    850                 855                 860                 
Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser
865                 870                 875                 880 
Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln
                885                 890                 895     
Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly
            900                 905                 910         
Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val
        915                 920                 925             
Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln
    930                 935                 940                 
Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser
945                 950                 955                 960 
Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met
                965                 970                 975     
Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln
            980                 985                 990         
Ala Gln Leu Phe His Pro Gln Asn Pro Ile Ala Asp Ala Gln Asn Leu
        995                 1000                1005            
Ser Gln Glu Thr Gln Gly Ser Leu Phe His Ser Pro Asn Pro Ile Val
    1010                1015                1020                
His Ser Gln Thr Ser Thr Thr Ser Ser Glu Gln Met Gln Pro Pro Met
1025                1030                1035                1040
Phe His Ser Gln Ser Thr Ile Ala Val Leu Gln Gly Ser Ser Val Pro
                1045                1050                1055    
Gln Asp Gln Gln Ser Thr Asn Ile Phe Leu Ser Gln Ser Pro Met Asn
            1060                1065                1070        
Asn Leu Gln Thr Asn Thr Val Ala Gln Glu Ala Phe Phe Ala Ala Pro
        1075                1080                1085            
Asn Ser Ile Ser Pro Leu Gln Ser Thr Ser Asn Ser Glu Gln Gln Ala
    1090                1095                1100                
Ala Phe Gln Gln Gln Ala Pro Ile Ser His Ile Gln Thr Pro Met Leu
1105                1110                1115                1120
Ser Gln Glu Gln Ala Gln Pro Pro Gln Gln Gly Leu Phe Gln Pro Gln
                1125                1130                1135    
Val Ala Leu Gly Ser Leu Pro Pro Asn Pro Met Pro Gln Ser Gln Gln
            1140                1145                1150        
Gly Thr Met Phe Gln Ser Gln His Ser Ile Val Ala Met Gln Ser Asn
        1155                1160                1165            
Ser Pro Ser Gln Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1170                1175                1180                
Gln Gln Gln Gln Gln Gln Ser Ile Leu Phe Ser Asn Gln Asn Thr Met
1185                1190                1195                1200
Ala Thr Met Ala Ser Pro Lys Gln Pro Pro Pro Asn Met Ile Phe Asn
                1205                1210                1215    
Pro Asn Gln Asn Pro Met Ala Asn Gln Glu Gln Gln Asn Gln Ser Ile
            1220                1225                1230        
Phe His Gln Gln Ser Asn Met Ala Pro Met Asn Gln Glu Gln Gln Pro
        1235                1240                1245            
Met Gln Phe Gln Ser Gln Ser Thr Val Ser Ser Leu Gln Asn Pro Gly
    1250                1255                1260                
Pro Thr Gln Ser Glu Ser Ser Gln Thr Pro Leu Phe His Ser Ser Pro
1265                1270                1275                1280
Gln Ile Gln Leu Val Gln Gly Ser Pro Ser Ser Gln Glu Gln Gln Val
                1285                1290                1295    
Thr Leu Phe Leu Ser Pro Ala Ser Met Ser Ala Leu Gln Thr Ser Ile
            1300                1305                1310        
Asn Gln Gln Asp Met Gln Gln Ser Pro Leu Tyr Ser Pro Gln Asn Asn
        1315                1320                1325            
Met Pro Gly Ile Gln Gly Ala Thr Ser Ser Pro Gln Pro Gln Ala Thr
    1330                1335                1340                
Leu Phe His Asn Thr Ala Gly Gly Thr Met Asn Gln Leu Gln Asn Ser
1345                1350                1355                1360
Pro Gly Ser Ser Gln Gln Thr Ser Gly Met Phe Leu Phe Gly Ile Gln
                1365                1370                1375    
Asn Asn Cys Ser Gln Leu Leu Thr Ser Gly Pro Ala Thr Leu Pro Asp
            1380                1385                1390        
Gln Leu Met Ala Ile Ser Gln Pro Gly Gln Pro Gln Asn Glu Gly Gln
        1395                1400                1405            
Pro Pro Val Thr Thr Leu Leu Ser Gln Gln Met Pro Glu Asn Ser Pro
    1410                1415                1420                
Leu Ala Ser Ser Ile Asn Thr Asn Gln Asn Ile Glu Lys Ile Asp Leu
1425                1430                1435                1440
Leu Val Ser Leu Gln Asn Gln Gly Asn Asn Leu Thr Gly Ser Phe
                1445                1450                1455


<210> 8297
<211> 1484
<212> PRT
<213> Homo sapiens

<400> 8297
Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala Val
 1               5                  10                  15      
Val Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly Gly
            20                  25                  30          
Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser Thr
        35                  40                  45              
Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser Ala
    50                  55                  60                  
Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser Asn
65                  70                  75                  80  
Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu Tyr
                85                  90                  95      
Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser Cys
            100                 105                 110         
Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met Trp
        115                 120                 125             
Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser Tyr
    130                 135                 140                 
Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro Lys
145                 150                 155                 160 
Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met Asp
                165                 170                 175     
Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser Gln
            180                 185                 190         
Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr Leu
        195                 200                 205             
Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys Gly
    210                 215                 220                 
Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val Gln
225                 230                 235                 240 
Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg Gly
                245                 250                 255     
Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu Glu
            260                 265                 270         
Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp Ser
        275                 280                 285             
Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr Gly
    290                 295                 300                 
Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr Val
305                 310                 315                 320 
Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val Asp
                325                 330                 335     
Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg Ile
            340                 345                 350         
Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val Phe
        355                 360                 365             
Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln Thr
    370                 375                 380                 
Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu Ile
385                 390                 395                 400 
Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu Val
                405                 410                 415     
Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe Gln
            420                 425                 430         
Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile Asp
        435                 440                 445             
Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro Tyr
    450                 455                 460                 
His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val Val
465                 470                 475                 480 
Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr Pro
                485                 490                 495     
Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu Ile
            500                 505                 510         
Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala Met
        515                 520                 525             
Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn Ala
    530                 535                 540                 
Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp Val
545                 550                 555                 560 
Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe Lys
                565                 570                 575     
Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile Ser
            580                 585                 590         
Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His Leu
        595                 600                 605             
Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr Asn
    610                 615                 620                 
Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro Gly
625                 630                 635                 640 
Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp Ala
                645                 650                 655     
Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser Arg
            660                 665                 670         
Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu Thr
        675                 680                 685             
Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala Gln
    690                 695                 700                 
Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn Ser
705                 710                 715                 720 
Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser Phe
                725                 730                 735     
Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val Gln
            740                 745                 750         
Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser Ala
        755                 760                 765             
Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile Phe
    770                 775                 780                 
Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe Ser
785                 790                 795                 800 
Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro Gly
                805                 810                 815     
Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn Gln
            820                 825                 830         
Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala Ala
        835                 840                 845             
Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln Ile
    850                 855                 860                 
Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu Gln
865                 870                 875                 880 
Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu Ser
                885                 890                 895     
Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro Pro
            900                 905                 910         
Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val Ala
        915                 920                 925             
Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly Asp Gly Glu
    930                 935                 940                 
Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val Phe Gln Thr
945                 950                 955                 960 
Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln Val Asn Leu
                965                 970                 975     
Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser Gly Thr Gln
            980                 985                 990         
Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met Met Ser Leu
        995                 1000                1005            
Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln Ala Gln Leu
    1010                1015                1020                
Phe His Pro Gln Asn Pro Ile Ala Asp Ala Gln Asn Leu Ser Gln Glu
1025                1030                1035                1040
Thr Gln Gly Ser Leu Phe His Ser Pro Asn Pro Ile Val His Ser Gln
                1045                1050                1055    
Thr Ser Thr Thr Ser Ser Glu Gln Met Gln Pro Pro Met Phe His Ser
            1060                1065                1070        
Gln Ser Thr Ile Ala Val Leu Gln Gly Ser Ser Val Pro Gln Asp Gln
        1075                1080                1085            
Gln Ser Thr Asn Ile Phe Leu Ser Gln Ser Pro Met Asn Asn Leu Gln
    1090                1095                1100                
Thr Asn Thr Val Ala Gln Glu Ala Phe Phe Ala Ala Pro Asn Ser Ile
1105                1110                1115                1120
Ser Pro Leu Gln Ser Thr Ser Asn Ser Glu Gln Gln Ala Ala Phe Gln
                1125                1130                1135    
Gln Gln Ala Pro Ile Ser His Ile Gln Thr Pro Met Leu Ser Gln Glu
            1140                1145                1150        
Gln Ala Gln Pro Pro Gln Gln Gly Leu Phe Gln Pro Gln Val Ala Leu
        1155                1160                1165            
Gly Ser Leu Pro Pro Asn Pro Met Pro Gln Ser Gln Gln Gly Thr Met
    1170                1175                1180                
Phe Gln Ser Gln His Ser Ile Val Ala Met Gln Ser Asn Ser Pro Ser
1185                1190                1195                1200
Gln Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
                1205                1210                1215    
Gln Gln Gln Ser Ile Leu Phe Ser Asn Gln Asn Thr Met Ala Thr Met
            1220                1225                1230        
Ala Ser Pro Lys Gln Pro Pro Pro Asn Met Ile Phe Asn Pro Asn Gln
        1235                1240                1245            
Asn Pro Met Ala Asn Gln Glu Gln Gln Asn Gln Ser Ile Phe His Gln
    1250                1255                1260                
Gln Ser Asn Met Ala Pro Met Asn Gln Glu Gln Gln Pro Met Gln Phe
1265                1270                1275                1280
Gln Ser Gln Ser Thr Val Ser Ser Leu Gln Asn Pro Gly Pro Thr Gln
                1285                1290                1295    
Ser Glu Ser Ser Gln Thr Pro Leu Phe His Ser Ser Pro Gln Ile Gln
            1300                1305                1310        
Leu Val Gln Gly Ser Pro Ser Ser Gln Glu Gln Gln Val Thr Leu Phe
        1315                1320                1325            
Leu Ser Pro Ala Ser Met Ser Ala Leu Gln Thr Ser Ile Asn Gln Gln
    1330                1335                1340                
Asp Met Gln Gln Ser Pro Leu Tyr Ser Pro Gln Asn Asn Met Pro Gly
1345                1350                1355                1360
Ile Gln Gly Ala Thr Ser Ser Pro Gln Pro Gln Ala Thr Leu Phe His
                1365                1370                1375    
Asn Thr Ala Gly Gly Thr Met Asn Gln Leu Gln Asn Ser Pro Gly Ser
            1380                1385                1390        
Ser Gln Gln Thr Ser Gly Met Phe Leu Phe Gly Ile Gln Asn Asn Cys
        1395                1400                1405            
Ser Gln Leu Leu Thr Ser Gly Pro Ala Thr Leu Pro Asp Gln Leu Met
    1410                1415                1420                
Ala Ile Ser Gln Pro Gly Gln Pro Gln Asn Glu Gly Gln Pro Pro Val
1425                1430                1435                1440
Thr Thr Leu Leu Ser Gln Gln Met Pro Glu Asn Ser Pro Leu Ala Ser
                1445                1450                1455    
Ser Ile Asn Thr Asn Gln Asn Ile Glu Lys Ile Asp Leu Leu Val Ser
            1460                1465                1470        
Leu Gln Asn Gln Gly Asn Asn Leu Thr Gly Ser Phe
        1475                1480                


<210> 8298
<211> 263
<212> PRT
<213> Homo sapiens

<400> 8298
Met Asp Glu Asp Gly Leu Glu Leu Gln Gln Glu Pro Asn Ser Phe Phe
 1               5                  10                  15      
Asp Ala Thr Gly Ala Asp Gly Thr His Met Asp Gly Asp Gln Ile Val
            20                  25                  30          
Val Glu Val Gln Glu Thr Val Phe Val Ser Asp Val Val Asp Ser Asp
        35                  40                  45              
Ile Thr Val His Asn Phe Val Pro Asp Asp Pro Asp Ser Val Val Ile
    50                  55                  60                  
Gln Asp Val Ile Glu Asp Val Val Ile Glu Asp Val Gln Cys Pro Asp
65                  70                  75                  80  
Ile Met Glu Glu Ala Asp Val Ser Glu Thr Val Ile Ile Pro Glu Gln
                85                  90                  95      
Val Leu Asp Ser Asp Val Thr Glu Glu Val Ser Leu Ala His Cys Thr
            100                 105                 110         
Val Pro Asp Asp Val Leu Ala Ser Asp Ile Thr Ser Ala Ser Met Ser
        115                 120                 125             
Met Pro Glu His Val Leu Thr Gly Asp Ser Ile His Val Ser Asp Val
    130                 135                 140                 
Gly His Val Gly His Val Gly His Val Glu His Val Val His Asp Ser
145                 150                 155                 160 
Val Val Glu Ala Glu Ile Val Thr Asp Pro Leu Thr Thr Asp Val Val
                165                 170                 175     
Ser Glu Glu Val Leu Val Ala Asp Cys Ala Ser Glu Ala Val Ile Asp
            180                 185                 190         
Ala Asn Gly Ile Pro Val Asp Gln Gln Asp Asp Asp Lys Gly Asn Cys
        195                 200                 205             
Glu Asp Tyr Leu Met Ile Ser Cys Asn Asn Ser Asp Gly Ile Glu Asn
    210                 215                 220                 
Arg Asn Gly Thr Ala Ser Ala Leu Leu His Ile Asp Glu Ser Ala Gly
225                 230                 235                 240 
Leu Gly Arg Leu Ala Lys Gln Lys Pro Lys Lys Arg Arg Arg Pro Asp
                245                 250                 255     
Ser Arg Gln Tyr Gln Thr Ala
            260             


<210> 8299
<211> 570
<212> PRT
<213> Homo sapiens

<400> 8299
Met Ala Lys Thr Pro Ser Asp His Leu Leu Ser Thr Leu Glu Glu Leu
 1               5                  10                  15      
Val Pro Tyr Asp Phe Glu Lys Phe Lys Phe Lys Leu Gln Asn Thr Ser
            20                  25                  30          
Val Gln Lys Glu His Ser Arg Ile Pro Arg Ser Gln Ile Gln Arg Ala
        35                  40                  45              
Arg Pro Val Lys Met Ala Thr Leu Leu Val Thr Tyr Tyr Gly Glu Glu
    50                  55                  60                  
Tyr Ala Val Gln Leu Thr Leu Gln Val Leu Arg Ala Ile Asn Gln Arg
65                  70                  75                  80  
Leu Leu Ala Glu Glu Leu His Arg Ala Ala Ile Gln Gly Arg Pro Pro
                85                  90                  95      
Asp Thr Ala Ala Ser Pro Arg Cys His Ala Gln Glu Gly Asp Pro Val
            100                 105                 110         
Asp Gly Thr Cys Val Arg Asp Ser Cys Ser Phe Pro Glu Ala Val Ser
        115                 120                 125             
Gly His Pro Gln Ala Ser Gly Ser Arg Ser Pro Gly Cys Pro Arg Cys
    130                 135                 140                 
Gln Asp Ser His Glu Arg Lys Ser Pro Gly Ser Leu Ser Pro Gln Pro
145                 150                 155                 160 
Leu Pro Gln Cys Lys Arg His Leu Lys Gln Val Gln Leu Leu Phe Cys
                165                 170                 175     
Glu Asp His Asp Glu Pro Ile Cys Leu Ile Cys Ser Leu Ser Gln Glu
            180                 185                 190         
His Gln Gly His Arg Val Arg Pro Ile Glu Glu Val Ala Leu Glu His
        195                 200                 205             
Lys Lys Lys Ile Gln Lys Gln Leu Glu His Leu Lys Lys Leu Arg Lys
    210                 215                 220                 
Ser Gly Glu Glu Gln Arg Ser Tyr Gly Glu Glu Lys Ala Val Ser Phe
225                 230                 235                 240 
Leu Lys Gln Thr Glu Ala Leu Lys Gln Arg Val Gln Arg Lys Leu Glu
                245                 250                 255     
Gln Val Tyr Tyr Phe Leu Glu Gln Gln Glu His Phe Phe Val Ala Ser
            260                 265                 270         
Leu Glu Asp Val Gly Gln Met Val Gly Gln Ile Arg Lys Ala Tyr Asp
        275                 280                 285             
Thr Arg Val Ser Gln Asp Ile Ala Leu Leu Asp Ala Leu Ile Gly Glu
    290                 295                 300                 
Leu Glu Ala Lys Glu Cys Gln Ser Glu Trp Glu Leu Leu Gln Asp Ile
305                 310                 315                 320 
Gly Asp Ile Leu His Arg Ala Lys Thr Val Pro Val Pro Glu Lys Trp
                325                 330                 335     
Thr Thr Pro Gln Glu Ile Lys Gln Lys Ile Gln Leu Leu His Gln Lys
            340                 345                 350         
Ser Glu Phe Val Glu Lys Ser Thr Lys Tyr Phe Ser Glu Thr Leu Arg
        355                 360                 365             
Ser Glu Met Glu Met Phe Asn Val Pro Glu Leu Ile Gly Ala Gln Ala
    370                 375                 380                 
His Ala Val Asn Val Ile Leu Asp Ala Glu Thr Ala Tyr Pro Asn Leu
385                 390                 395                 400 
Ile Phe Ser Asp Asp Leu Lys Ser Val Arg Leu Gly Asn Lys Trp Glu
                405                 410                 415     
Arg Leu Pro Asp Gly Pro Gln Arg Phe Asp Ser Cys Ile Ile Val Leu
            420                 425                 430         
Gly Ser Pro Ser Phe Leu Ser Gly Arg Arg Tyr Trp Glu Val Glu Val
        435                 440                 445             
Gly Asp Lys Thr Ala Trp Ile Leu Gly Ala Cys Lys Thr Ser Ile Ser
    450                 455                 460                 
Arg Lys Gly Asn Met Thr Leu Ser Pro Glu Asn Gly Tyr Trp Val Val
465                 470                 475                 480 
Ile Met Met Lys Glu Asn Glu Tyr Gln Ala Ser Ser Val Pro Pro Thr
                485                 490                 495     
Arg Leu Leu Ile Lys Glu Pro Pro Lys Arg Val Gly Ile Phe Val Asp
            500                 505                 510         
Tyr Arg Val Gly Ser Ile Ser Phe Tyr Asn Val Thr Ala Arg Ser His
        515                 520                 525             
Ile Tyr Thr Phe Ala Ser Cys Ser Phe Ser Gly Pro Leu Gln Pro Ile
    530                 535                 540                 
Phe Ser Pro Gly Thr Arg Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr
545                 550                 555                 560 
Ile Cys Pro Val Gly Gly Gln Gly Pro Asp
                565                 570 


<210> 8300
<211> 781
<212> PRT
<213> Homo sapiens

<400> 8300
Met Ala Lys Thr Pro Ser Asp His Leu Leu Ser Thr Leu Glu Glu Leu
 1               5                  10                  15      
Val Pro Tyr Asp Phe Glu Lys Phe Lys Phe Lys Leu Gln Asn Thr Ser
            20                  25                  30          
Val Gln Lys Glu His Ser Arg Ile Pro Arg Ser Gln Ile Gln Arg Ala
        35                  40                  45              
Arg Pro Val Lys Met Ala Thr Leu Leu Val Thr Tyr Tyr Gly Glu Glu
    50                  55                  60                  
Tyr Ala Val Gln Leu Thr Leu Gln Val Leu Arg Ala Ile Asn Gln Arg
65                  70                  75                  80  
Leu Leu Ala Glu Glu Leu His Arg Ala Ala Ile Gln Glu Tyr Ser Thr
                85                  90                  95      
Gln Glu Asn Gly Thr Asp Asp Ser Ala Ala Ser Ser Ser Leu Gly Glu
            100                 105                 110         
Asn Lys Pro Arg Ser Leu Lys Thr Pro Asp His Pro Glu Gly Asn Glu
        115                 120                 125             
Gly Asn Gly Pro Arg Pro Tyr Gly Gly Gly Ala Ala Ser Leu Arg Cys
    130                 135                 140                 
Ser Gln Pro Glu Ala Gly Arg Gly Leu Ser Arg Lys Pro Leu Ser Lys
145                 150                 155                 160 
Arg Arg Glu Lys Ala Ser Glu Gly Leu Asp Ala Gln Gly Lys Pro Arg
                165                 170                 175     
Thr Arg Ser Pro Ala Leu Pro Gly Gly Arg Ser Pro Gly Pro Cys Arg
            180                 185                 190         
Ala Leu Glu Gly Gly Gln Ala Glu Val Arg Leu Arg Arg Asn Ala Ser
        195                 200                 205             
Ser Ala Gly Arg Leu Gln Gly Leu Ala Gly Gly Ala Pro Gly Gln Lys
    210                 215                 220                 
Glu Cys Arg Pro Phe Glu Val Tyr Leu Pro Ser Gly Lys Met Arg Pro
225                 230                 235                 240 
Arg Ser Leu Glu Val Thr Ile Ser Thr Gly Glu Lys Ala Pro Ala Asn
                245                 250                 255     
Pro Glu Ile Leu Leu Thr Leu Glu Glu Lys Thr Ala Ala Asn Leu Asp
            260                 265                 270         
Ser Ala Thr Glu Pro Arg Ala Arg Pro Thr Pro Asp Gly Gly Ala Ser
        275                 280                 285             
Ala Asp Leu Lys Glu Gly Pro Gly Asn Pro Glu His Ser Val Thr Gly
    290                 295                 300                 
Arg Pro Pro Asp Thr Ala Ala Ser Pro Arg Cys His Ala Gln Glu Gly
305                 310                 315                 320 
Asp Pro Val Asp Gly Thr Cys Val Arg Asp Ser Cys Ser Phe Pro Glu
                325                 330                 335     
Ala Val Ser Gly His Pro Gln Ala Ser Gly Ser Arg Ser Pro Gly Cys
            340                 345                 350         
Pro Arg Cys Gln Asp Ser His Glu Arg Lys Ser Pro Gly Ser Leu Ser
        355                 360                 365             
Pro Gln Pro Leu Pro Gln Cys Lys Arg His Leu Lys Gln Val Gln Leu
    370                 375                 380                 
Leu Phe Cys Glu Asp His Asp Glu Pro Ile Cys Leu Ile Cys Ser Leu
385                 390                 395                 400 
Ser Gln Glu His Gln Gly His Arg Val Arg Pro Ile Glu Glu Val Ala
                405                 410                 415     
Leu Glu His Lys Lys Lys Ile Gln Lys Gln Leu Glu His Leu Lys Lys
            420                 425                 430         
Leu Arg Lys Ser Gly Glu Glu Gln Arg Ser Tyr Gly Glu Glu Lys Ala
        435                 440                 445             
Val Ser Phe Leu Lys Gln Thr Glu Ala Leu Lys Gln Arg Val Gln Arg
    450                 455                 460                 
Lys Leu Glu Gln Val Tyr Tyr Phe Leu Glu Gln Gln Glu His Phe Phe
465                 470                 475                 480 
Val Ala Ser Leu Glu Asp Val Gly Gln Met Val Gly Gln Ile Arg Lys
                485                 490                 495     
Ala Tyr Asp Thr Arg Val Ser Gln Asp Ile Ala Leu Leu Asp Ala Leu
            500                 505                 510         
Ile Gly Glu Leu Glu Ala Lys Glu Cys Gln Ser Glu Trp Glu Leu Leu
        515                 520                 525             
Gln Asp Ile Gly Asp Ile Leu His Arg Ala Lys Thr Val Pro Val Pro
    530                 535                 540                 
Glu Lys Trp Thr Thr Pro Gln Glu Ile Lys Gln Lys Ile Gln Leu Leu
545                 550                 555                 560 
His Gln Lys Ser Glu Phe Val Glu Lys Ser Thr Lys Tyr Phe Ser Glu
                565                 570                 575     
Thr Leu Arg Ser Glu Met Glu Met Phe Asn Val Pro Glu Leu Ile Gly
            580                 585                 590         
Ala Gln Ala His Ala Val Asn Val Ile Leu Asp Ala Glu Thr Ala Tyr
        595                 600                 605             
Pro Asn Leu Ile Phe Ser Asp Asp Leu Lys Ser Val Arg Leu Gly Asn
    610                 615                 620                 
Lys Trp Glu Arg Leu Pro Asp Gly Pro Gln Arg Phe Asp Ser Cys Ile
625                 630                 635                 640 
Ile Val Leu Gly Ser Pro Ser Phe Leu Ser Gly Arg Arg Tyr Trp Glu
                645                 650                 655     
Val Glu Val Gly Asp Lys Thr Ala Trp Ile Leu Gly Ala Cys Lys Thr
            660                 665                 670         
Ser Ile Ser Arg Lys Gly Asn Met Thr Leu Ser Pro Glu Asn Gly Tyr
        675                 680                 685             
Trp Val Val Ile Met Met Lys Glu Asn Glu Tyr Gln Ala Ser Ser Val
    690                 695                 700                 
Pro Pro Thr Arg Leu Leu Ile Lys Glu Pro Pro Lys Arg Val Gly Ile
705                 710                 715                 720 
Phe Val Asp Tyr Arg Val Gly Ser Ile Ser Phe Tyr Asn Val Thr Ala
                725                 730                 735     
Arg Ser His Ile Tyr Thr Phe Ala Ser Cys Ser Phe Ser Gly Pro Leu
            740                 745                 750         
Gln Pro Ile Phe Ser Pro Gly Thr Arg Asp Gly Gly Lys Asn Thr Ala
        755                 760                 765             
Pro Leu Thr Ile Cys Pro Val Gly Gly Gln Gly Pro Asp
    770                 775                 780     


<210> 8301
<211> 329
<212> PRT
<213> Homo sapiens

<400> 8301
Met Gly Asn Val Leu Ala Ala Ser Ser Pro Pro Ala Gly Pro Pro Pro
 1               5                  10                  15      
Pro Pro Ala Pro Ala Leu Val Gly Leu Pro Pro Pro Pro Pro Ser Pro
            20                  25                  30          
Pro Gly Phe Thr Leu Pro Pro Leu Gly Gly Ser Leu Gly Ala Gly Thr
        35                  40                  45              
Ser Thr Ser Arg Ser Ser Glu Arg Thr Pro Gly Ala Ala Thr Ala Ser
    50                  55                  60                  
Ala Ser Gly Ala Ala Glu Asp Gly Ala Cys Gly Cys Leu Pro Asn Pro
65                  70                  75                  80  
Gly Thr Phe Glu Glu Cys His Arg Lys Cys Lys Glu Leu Phe Pro Ile
                85                  90                  95      
Gln Met Glu Gly Val Lys Leu Thr Val Asn Lys Gly Leu Ser Asn His
            100                 105                 110         
Phe Gln Val Asn His Thr Val Ala Leu Ser Thr Ile Gly Glu Ser Asn
        115                 120                 125             
Tyr His Phe Gly Val Thr Tyr Val Gly Thr Lys Gln Leu Ser Pro Thr
    130                 135                 140                 
Glu Ala Phe Pro Val Leu Val Gly Asp Met Asp Asn Ser Gly Ser Leu
145                 150                 155                 160 
Asn Ala Gln Val Ile His Gln Leu Gly Pro Gly Leu Arg Ser Lys Met
                165                 170                 175     
Ala Ile Gln Thr Gln Gln Ser Lys Phe Val Asn Trp Gln Val Asp Gly
            180                 185                 190         
Glu Tyr Arg Gly Ser Asp Phe Thr Ala Ala Val Thr Leu Gly Asn Pro
        195                 200                 205             
Asp Val Leu Val Gly Ser Gly Ile Leu Val Ala His Tyr Leu Gln Ser
    210                 215                 220                 
Ile Thr Pro Cys Leu Ala Leu Gly Gly Glu Leu Val Tyr His Arg Arg
225                 230                 235                 240 
Pro Gly Glu Glu Gly Thr Val Met Ser Leu Ala Gly Lys Tyr Thr Leu
                245                 250                 255     
Asn Asn Trp Leu Ala Thr Val Thr Leu Gly Gln Ala Gly Met His Ala
            260                 265                 270         
Thr Tyr Tyr His Lys Ala Ser Asp Gln Leu Gln Val Gly Val Glu Phe
        275                 280                 285             
Glu Ala Ser Thr Arg Met Gln Asp Thr Ser Val Ser Phe Gly Tyr Gln
    290                 295                 300                 
Leu Asp Leu Pro Lys Ala Asn Leu Leu Phe Lys Gly Lys Gly Leu Gly
305                 310                 315                 320 
Ser Pro Thr Arg Glu Thr Gly Arg Arg
                325                 


<210> 8302
<211> 361
<212> PRT
<213> Homo sapiens

<400> 8302
Met Gly Asn Val Leu Ala Ala Ser Ser Pro Pro Ala Gly Pro Pro Pro
 1               5                  10                  15      
Pro Pro Ala Pro Ala Leu Val Gly Leu Pro Pro Pro Pro Pro Ser Pro
            20                  25                  30          
Pro Gly Phe Thr Leu Pro Pro Leu Gly Gly Ser Leu Gly Ala Gly Thr
        35                  40                  45              
Ser Thr Ser Arg Ser Ser Glu Arg Thr Pro Gly Ala Ala Thr Ala Ser
    50                  55                  60                  
Ala Ser Gly Ala Ala Glu Asp Gly Ala Cys Gly Cys Leu Pro Asn Pro
65                  70                  75                  80  
Gly Thr Phe Glu Glu Cys His Arg Lys Cys Lys Glu Leu Phe Pro Ile
                85                  90                  95      
Gln Met Glu Gly Val Lys Leu Thr Val Asn Lys Gly Leu Ser Asn His
            100                 105                 110         
Phe Gln Val Asn His Thr Val Ala Leu Ser Thr Ile Gly Glu Ser Asn
        115                 120                 125             
Tyr His Phe Gly Val Thr Tyr Val Gly Thr Lys Gln Leu Ser Pro Thr
    130                 135                 140                 
Glu Ala Phe Pro Val Leu Val Gly Asp Met Asp Asn Ser Gly Ser Leu
145                 150                 155                 160 
Asn Ala Gln Val Ile His Gln Leu Gly Pro Gly Leu Arg Ser Lys Met
                165                 170                 175     
Ala Ile Gln Thr Gln Gln Ser Lys Phe Val Asn Trp Gln Val Asp Gly
            180                 185                 190         
Glu Tyr Arg Gly Ser Asp Phe Thr Ala Ala Val Thr Leu Gly Asn Pro
        195                 200                 205             
Asp Val Leu Val Gly Ser Gly Ile Leu Val Ala His Tyr Leu Gln Ser
    210                 215                 220                 
Ile Thr Pro Cys Leu Ala Leu Gly Gly Glu Leu Val Tyr His Arg Arg
225                 230                 235                 240 
Pro Gly Glu Glu Gly Thr Val Met Ser Leu Ala Gly Lys Tyr Thr Leu
                245                 250                 255     
Asn Asn Trp Leu Ala Thr Val Thr Leu Gly Gln Ala Gly Met His Ala
            260                 265                 270         
Thr Tyr Tyr His Lys Ala Ser Asp Gln Leu Gln Val Gly Val Glu Phe
        275                 280                 285             
Glu Ala Ser Thr Arg Met Gln Asp Thr Ser Val Ser Phe Gly Tyr Gln
    290                 295                 300                 
Leu Asp Leu Pro Lys Ala Asn Leu Leu Phe Lys Gly Ser Val Asp Ser
305                 310                 315                 320 
Asn Trp Ile Val Gly Ala Thr Leu Glu Lys Lys Leu Pro Pro Leu Pro
                325                 330                 335     
Leu Thr Leu Ala Leu Gly Ala Phe Leu Asn His Arg Lys Asn Lys Phe
            340                 345                 350         
Gln Cys Gly Phe Gly Leu Thr Ile Gly
        355                 360     


<210> 8303
<211> 739
<212> PRT
<213> Homo sapiens

<400> 8303
Met Ile Pro Tyr Gly Phe Asn Asn Gln Thr Lys His Cys Leu Arg Arg
 1               5                  10                  15      
Leu Gly Lys Arg Tyr Glu Phe Gln Ile Gln Asp Leu Arg Pro Glu Asp
            20                  25                  30          
Ser Gly Ile Tyr Gln Val Lys Val Glu Asp Ala Val Val Phe Ser Thr
        35                  40                  45              
Glu Leu Glu Ala Ser Ala Ile Pro Pro Arg Val Val Val Pro Leu Ala
    50                  55                  60                  
Glu Thr His Cys Glu Glu Gln Gly Asp Ala Val Phe Glu Cys Thr Leu
65                  70                  75                  80  
Ser Ser Pro Cys Pro Ser Ala Ala Trp His Phe Arg His Arg Leu Leu
                85                  90                  95      
His Pro Ser Asp Lys Tyr Glu Val Tyr Val Ser Pro Asp Gly Leu Thr
            100                 105                 110         
His Arg Leu Val Val Arg Gly Ala Arg Phe Ser Asp Met Gly Pro Tyr
        115                 120                 125             
Ser Leu Gly Thr Gly Leu Tyr Thr Ser Ser Ala Trp Leu Val Val Glu
    130                 135                 140                 
Ala Gly Lys Asp Lys Asp Leu Gln Ser Thr Ser Ala Asp His Lys Leu
145                 150                 155                 160 
Gln Arg Gln Gly Ala Gln Ala Ser Gly Ala Glu Glu Ser Gly Ser Ile
                165                 170                 175     
Glu Ser Gln Gly Glu Lys Ser Arg Glu Gln Gly Pro Arg Gly Gly Ser
            180                 185                 190         
Leu Glu Gly Ala Gly Pro Ala Ser Gly Leu Gln His Ile Ala Ser Pro
        195                 200                 205             
Asp Arg Asp Gly Leu Gly Arg His Gly Tyr Ser Leu Met Gly Asp Lys
    210                 215                 220                 
Gly Thr Ala Asp Ser Ala Trp Gly Pro Gly Gln Glu Gly Glu Gly Phe
225                 230                 235                 240 
Pro Val Ala Glu Gly Ser Arg Ala Thr Leu Pro Arg Glu Asn Gln Ser
                245                 250                 255     
His Arg Glu Gly Gly Trp Ala Arg Ser Leu Ala Glu Arg Pro His Leu
            260                 265                 270         
Gln Gly Glu Ser Ser Glu Ser Gly Leu Gly Leu Pro Glu Lys Gln Gln
        275                 280                 285             
Gln Asp Arg Gly Arg Asp Ser Asn Ser Asp Glu Cys Trp Arg Lys Ala
    290                 295                 300                 
Gly Gly Trp Glu Ala Gly Ser Ser Arg Leu Gln Ala Gly Gly Leu Gly
305                 310                 315                 320 
Ser Ser Arg Glu Gly Lys Glu His Arg Gly Asp Ser Gly Arg Gln Leu
                325                 330                 335     
Asp Arg His Ala Pro Glu Gln Leu Trp Asp Ala Arg Leu Gly Pro Gly
            340                 345                 350         
Arg Gly Lys Ser Asp Leu Gln Gly Cys Gln Ser Asp Pro Val Gly Ser
        355                 360                 365             
Trp Pro Arg Gly Lys Gln Ile Glu Ile Ser Gln Asp Asp Ser Leu Ala
    370                 375                 380                 
Glu Met Asp Arg Gly Asp Ala Pro Ser Arg Glu Arg Gly Arg Gly Ile
385                 390                 395                 400 
Val Val Trp Gly Gly Gly Thr Gly Leu Gly Glu Ala Gly Asp Ser Asn
                405                 410                 415     
Gly Ala Gly Gly Pro Gly Thr Leu Glu Leu Thr Gly Gly Arg Gly Ser
            420                 425                 430         
Gly Ser Lys Val Gly Met Ala Pro Glu Ser Trp Gly Ser Gln Gly Gly
        435                 440                 445             
Arg Asp Ala Asp Tyr Gly Glu Ala Arg Gly Tyr Trp Gly Ser Gly Glu
    450                 455                 460                 
Leu Leu Glu Gln Ile Pro Gly Gly Lys Asp Phe Gln Glu Pro Ser Ile
465                 470                 475                 480 
Ser Gly Gly Arg Lys Phe Leu Leu Gly Asp Gly Ser Pro Glu Ile Lys
                485                 490                 495     
Ala Glu Asp Ser Leu Gln Glu Ala Asp Gly Ile Cys Arg Gly Glu Ser
            500                 505                 510         
Val Val Thr Gly Ser Ala Tyr Lys Thr Gly Pro Gly Gly Pro Gly Asp
        515                 520                 525             
Pro Arg Gly Cys Glu Gly Val Leu Gln Glu Leu Arg Gly Arg Asp Gly
    530                 535                 540                 
Gln Glu Thr Ala Trp Ala Ser Gly Glu Val Glu Tyr Asp Pro Arg Ser
545                 550                 555                 560 
Phe Gln Ser Ser Gln Gly Trp Thr Ala Gly His Arg Ala Ala Gly Gly
                565                 570                 575     
Ile Gly Arg Ile Glu Ser Lys Gly Thr Ser Pro Trp Asp Asp Thr Pro
            580                 585                 590         
Ser Ser Leu Arg Lys Thr Gly Ala His His Gly Pro Gly Val Leu Gly
        595                 600                 605             
Pro Ser Gly Gly Gln Glu Gly Met Gly Gly Ile Trp Val Ala Gly Leu
    610                 615                 620                 
Thr Glu Ser Gly Gln Gly Val Asp Ala Arg Ser His Trp Leu Ser Arg
625                 630                 635                 640 
Ala Pro Gly Leu Gly Ala Gln Gly Ser Gly Gly Thr Leu Gly Asp Lys
                645                 650                 655     
Lys Gly Leu Arg Gly Pro Gly Ser Ile Gly Ser Glu Pro Asp Phe Trp
            660                 665                 670         
Asn Gly Ser Gly Ser Ser Arg Val Lys Gly Pro Arg Gly His Leu Arg
        675                 680                 685             
Glu Trp Ser Leu Arg Lys Gly Val Gly Thr Gly Met Ala Pro Glu Arg
    690                 695                 700                 
Leu Gly Glu Cys Gly Leu Glu Met Lys Ile Leu Ala Leu Gln Glu Glu
705                 710                 715                 720 
Gly Leu Gly Glu Leu Pro Val Leu Lys Met Ala Gln Val Val Leu Met
                725                 730                 735     
Glu His Pro
            


<210> 8304
<211> 504
<212> PRT
<213> Homo sapiens

<400> 8304
Met Val Leu Ala Asp Leu Gly Arg Lys Ile Thr Ser Ala Leu Arg Ser
 1               5                  10                  15      
Leu Ser Asn Ala Thr Ile Ile Asn Glu Glu Val Leu Asn Ala Met Leu
            20                  25                  30          
Lys Glu Val Cys Thr Ala Leu Leu Glu Ala Asp Val Asn Ile Lys Leu
        35                  40                  45              
Val Lys Gln Leu Arg Glu Asn Val Lys Ser Ala Ile Asp Leu Glu Glu
    50                  55                  60                  
Met Ala Ser Gly Leu Asn Lys Arg Lys Met Ile Gln His Ala Val Phe
65                  70                  75                  80  
Lys Glu Leu Val Lys Leu Val Asp Pro Gly Val Lys Ala Trp Thr Pro
                85                  90                  95      
Thr Lys Gly Lys Gln Asn Val Ile Met Phe Val Gly Leu Gln Gly Ser
            100                 105                 110         
Gly Lys Thr Thr Thr Cys Ser Lys Leu Ala Tyr Tyr Tyr Gln Arg Lys
        115                 120                 125             
Gly Trp Lys Thr Cys Leu Ile Cys Ala Asp Thr Phe Arg Ala Gly Ala
    130                 135                 140                 
Phe Asp Gln Leu Lys Gln Asn Ala Thr Lys Ala Arg Ile Pro Phe Tyr
145                 150                 155                 160 
Gly Ser Tyr Thr Glu Met Asp Pro Val Ile Ile Ala Ser Glu Gly Val
                165                 170                 175     
Glu Lys Phe Lys Asn Glu Asn Phe Glu Ile Ile Ile Val Asp Thr Ser
            180                 185                 190         
Gly Arg His Lys Gln Glu Asp Ser Leu Phe Glu Glu Met Leu Gln Val
        195                 200                 205             
Ala Asn Ala Ile Gln Pro Asp Asn Ile Val Tyr Val Met Asp Ala Ser
    210                 215                 220                 
Ile Gly Gln Ala Cys Glu Ala Gln Ala Lys Ala Phe Lys Asp Lys Val
225                 230                 235                 240 
Asp Val Ala Ser Val Ile Val Thr Lys Leu Asp Gly His Ala Lys Gly
                245                 250                 255     
Gly Gly Ala Leu Ser Ala Val Ala Ala Thr Lys Ser Pro Ile Ile Phe
            260                 265                 270         
Ile Gly Thr Gly Glu His Ile Asp Asp Phe Glu Pro Phe Lys Thr Gln
        275                 280                 285             
Pro Phe Ile Ser Lys Leu Leu Gly Met Gly Asp Ile Glu Gly Leu Ile
    290                 295                 300                 
Asp Lys Val Asn Glu Leu Lys Leu Asp Asp Asn Glu Ala Leu Ile Glu
305                 310                 315                 320 
Lys Leu Lys His Gly Gln Phe Thr Leu Arg Asp Met Tyr Glu Gln Phe
                325                 330                 335     
Gln Asn Ile Met Lys Met Gly Pro Phe Ser Gln Ile Leu Gly Met Ile
            340                 345                 350         
Pro Gly Phe Gly Thr Asp Phe Met Ser Lys Gly Asn Glu Gln Glu Ser
        355                 360                 365             
Met Ala Arg Leu Lys Lys Leu Met Thr Ile Met Asp Ser Met Asn Asp
    370                 375                 380                 
Gln Glu Leu Asp Ser Thr Asp Gly Ala Lys Val Phe Ser Lys Gln Pro
385                 390                 395                 400 
Gly Arg Ile Gln Arg Val Ala Arg Gly Ser Gly Val Ser Thr Arg Asp
                405                 410                 415     
Val Gln Glu Leu Leu Thr Gln Tyr Thr Lys Phe Ala Gln Met Val Lys
            420                 425                 430         
Lys Met Gly Gly Ile Lys Gly Leu Phe Lys Gly Gly Asp Met Ser Lys
        435                 440                 445             
Asn Val Ser Gln Ser Gln Met Ala Lys Leu Asn Gln Gln Met Ala Lys
    450                 455                 460                 
Met Met Asp Pro Arg Val Leu His His Met Gly Gly Met Ala Gly Leu
465                 470                 475                 480 
Gln Ser Met Met Arg Gln Phe Gln Gln Gly Ala Ala Gly Asn Met Lys
                485                 490                 495     
Gly Met Met Gly Phe Asn Asn Met
            500                 


<210> 8305
<211> 618
<212> PRT
<213> Homo sapiens

<400> 8305
Met Ala Ala Val Ala Ala Gly Gly Leu Val Gly Lys Gly Arg Asp Ile
 1               5                  10                  15      
Ser Leu Ala Ala Leu Gln Arg His Asp Pro Tyr Ile Asn Arg Ile Val
            20                  25                  30          
Asp Val Ala Ser Gln Val Ala Leu Tyr Thr Phe Gly His Arg Ala Asn
        35                  40                  45              
Glu Trp Glu Lys Thr Asp Val Glu Gly Thr Leu Phe Val Tyr Thr Arg
    50                  55                  60                  
Ser Ala Ser Pro Lys His Gly Phe Thr Ile Met Asn Arg Leu Ser Met
65                  70                  75                  80  
Glu Asn Arg Thr Glu Pro Ile Thr Lys Asp Leu Asp Phe Gln Leu Gln
                85                  90                  95      
Asp Pro Phe Leu Leu Tyr Arg Asn Ala Arg Leu Ser Ile Tyr Gly Ile
            100                 105                 110         
Trp Phe Tyr Asp Lys Glu Glu Cys Gln Arg Ile Ala Glu Leu Met Lys
        115                 120                 125             
Asn Leu Thr Gln Tyr Glu Gln Leu Lys Ala His Gln Gly Thr Gly Ala
    130                 135                 140                 
Gly Ile Ser Pro Val Ile Leu Asn Ser Gly Glu Gly Lys Glu Val Asp
145                 150                 155                 160 
Ile Leu Arg Met Leu Ile Lys Ala Lys Asp Glu Tyr Thr Lys Cys Lys
                165                 170                 175     
Thr Cys Ser Glu Pro Lys Lys Ile Thr Ser Ser Ser Ala Ile Tyr Asp
            180                 185                 190         
Asn Pro Asn Leu Ile Lys Pro Ile Pro Val Lys Pro Ser Glu Asn Gln
        195                 200                 205             
Gln Gln Arg Ile Pro Gln Pro Asn Gln Thr Leu Asp Pro Glu Pro Gln
    210                 215                 220                 
His Leu Ser Leu Thr Ala Leu Phe Gly Lys Gln Asp Lys Ala Thr Cys
225                 230                 235                 240 
Gln Glu Thr Val Glu Pro Pro Gln Thr Leu His Gln Gln Gln Gln Gln
                245                 250                 255     
Gln Gln Gln Gln Gln Gln Glu Lys Leu Pro Ile Arg Gln Gly Val Val
            260                 265                 270         
Arg Ser Leu Ser Tyr Glu Glu Pro Arg Arg His Ser Pro Pro Ile Glu
        275                 280                 285             
Lys Gln Leu Cys Pro Ala Ile Gln Lys Leu Met Val Arg Ser Ala Asp
    290                 295                 300                 
Leu His Pro Leu Ser Glu Leu Pro Glu Asn Arg Pro Cys Glu Asn Gly
305                 310                 315                 320 
Ser Thr His Ser Ala Gly Glu Phe Phe Thr Gly Pro Val Gln Pro Gly
                325                 330                 335     
Ser Pro His Asn Ile Gly Thr Ser Arg Gly Val Gln Asn Ala Ser Arg
            340                 345                 350         
Thr Gln Asn Leu Phe Glu Lys Leu Gln Ser Thr Pro Gly Ala Ala Asn
        355                 360                 365             
Lys Cys Asp Pro Ser Thr Pro Ala Pro Ala Ser Ser Ala Ala Leu Asn
    370                 375                 380                 
Arg Ser Arg Ala Pro Thr Ser Val Thr Pro Val Ala Pro Gly Lys Gly
385                 390                 395                 400 
Leu Ala Gln Pro Pro Gln Ala Tyr Phe Asn Gly Ser Leu Pro Pro Gln
                405                 410                 415     
Thr Val Gly His Gln Ala His Gly Arg Glu Gln Ser Thr Leu Pro Arg
            420                 425                 430         
Gln Thr Leu Pro Ile Ser Gly Ser Gln Thr Gly Ser Ser Gly Val Ile
        435                 440                 445             
Ser Pro Gln Glu Leu Leu Lys Lys Leu Gln Ile Val Gln Gln Glu Gln
    450                 455                 460                 
Gln Leu His Ala Ser Asn Arg Pro Ala Leu Ala Ala Lys Phe Pro Val
465                 470                 475                 480 
Leu Ala Gln Ser Ser Gly Thr Gly Lys Pro Leu Glu Ser Trp Ile Asn
                485                 490                 495     
Lys Thr Pro Asn Thr Glu Gln Gln Thr Pro Leu Phe Gln Val Ile Ser
            500                 505                 510         
Pro Gln Arg Ile Pro Ala Thr Ala Ala Pro Ser Leu Leu Met Ser Pro
        515                 520                 525             
Met Val Phe Ala Gln Pro Thr Ser Val Pro Pro Lys Glu Arg Glu Ser
    530                 535                 540                 
Gly Leu Leu Pro Val Gly Gly Gln Glu Pro Pro Ala Ala Ala Thr Ser
545                 550                 555                 560 
Leu Leu Leu Pro Ile Gln Ser Pro Glu Pro Ser Val Ile Thr Ser Ser
                565                 570                 575     
Pro Leu Thr Lys Leu Gln Leu Gln Glu Ala Leu Leu Tyr Leu Ile Gln
            580                 585                 590         
Asn Asp Asp Asn Phe Leu Asn Ile Ile Tyr Glu Ala Tyr Leu Phe Ser
        595                 600                 605             
Met Thr Gln Ala Ala Met Lys Lys Thr Met
    610                 615             


<210> 8306
<211> 139
<212> PRT
<213> Homo sapiens

<400> 8306
Asn Glu Asn Asn Ala Ala Gly Tyr Ser Cys Gly Pro Gly Thr Leu Lys
 1               5                  10                  15      
Met Asn Gly Lys Leu Ser Glu Glu Arg Thr Glu Asp Thr Asp Cys Asp
            20                  25                  30          
Gly Ser Pro Leu Pro Glu Tyr Phe Thr Glu Ala Thr Lys Met Asn Gly
        35                  40                  45              
Cys Glu Glu Tyr Cys Glu Glu Lys Val Lys Ser Glu Ser Leu Ile Gln
    50                  55                  60                  
Lys Pro Gln Glu Lys Lys Thr Asp Asp Asp Glu Ile Thr Trp Gly Asn
65                  70                  75                  80  
Asp Glu Leu Pro Ile Glu Arg Thr Asn His Glu Asp Ser Asp Lys Gly
                85                  90                  95      
Lys Asn Phe Asn Asp Asn His Ser Phe Leu Thr Asn Asp Glu Leu Ala
            100                 105                 110         
Val Leu Pro Val Val Lys Val Leu Pro Ser Gly Lys Tyr Thr Gly Ala
        115                 120                 125             
Asn Leu Lys Ser Val Ile Arg Val Leu Arg Gly
    130                 135                 


<210> 8307
<211> 378
<212> PRT
<213> Homo sapiens

<400> 8307
Met Glu Val Ile Asn Leu Thr Thr Leu Pro Met Ile Pro Val Asp Glu
 1               5                  10                  15      
His Leu Ala Val Ser Leu Val Ala Arg Asn Thr Met Val Lys Thr Val
            20                  25                  30          
Arg Lys Glu Leu Glu Asn Asn Pro Pro Ser Cys Leu Ile Gly Ser Met
        35                  40                  45              
His Gln Val Asn Gln Lys Ile Ala Asp Ile Asn Leu Arg Thr Glu Pro
    50                  55                  60                  
Ser Ala Asn Ser Leu Ala Ile Glu Arg Phe Glu Leu Glu Lys Lys Ala
65                  70                  75                  80  
Leu Arg Glu Lys Thr Arg Ser Ser Pro Glu Asp Lys Gly Lys Asn Leu
                85                  90                  95      
Ser Leu Ser Leu Asp Ala Leu Phe Met Gly Lys Ser Gln Tyr Ser Cys
            100                 105                 110         
Lys Gly Ser Glu Leu Arg His Ala Arg Ser Ser Val Ile Lys Arg Lys
        115                 120                 125             
Thr Ala Asp Lys Asn Leu Leu Ala Glu Leu Tyr Gln Tyr Ser Asn Phe
    130                 135                 140                 
Asn Ser Ser Lys Pro Asn Lys Leu Pro Asn Gly Val Asp Phe Cys Asp
145                 150                 155                 160 
Met Val Gly Asn Val Val Arg Ala Glu Arg Asp Cys Leu Ser Gly Lys
                165                 170                 175     
His Phe Cys Ser Gly Arg Glu Leu Glu Lys Phe Leu Ser Ser Ser Ser
            180                 185                 190         
Pro Arg Ala Ile Trp Leu Asp Ser Phe Trp Trp Ile Phe His Glu Arg
        195                 200                 205             
Tyr Gln Pro Asn Lys Glu Leu Gln Asn Asn Leu Phe Asp Arg Ile Ala
    210                 215                 220                 
Gln His Tyr Ala Leu Leu Leu Phe Arg Val Pro Lys Ser His Ser Glu
225                 230                 235                 240 
Glu Ala Leu Leu Lys Arg Leu Pro Ser Leu Leu Ser Lys Ala Val Tyr
                245                 250                 255     
Thr Ser Phe Cys Cys Cys Phe Pro Gln Ser Trp Phe Asp Thr His Glu
            260                 265                 270         
Phe Lys Ser Asp Ile Cys Asn Thr Met Ser Leu Trp Ile Ser Gly Thr
        275                 280                 285             
Tyr Pro Ser Pro Gln Ser Tyr Asp Ser Trp Asp Tyr Ser Glu Leu Asp
    290                 295                 300                 
Pro Glu Arg Phe Arg Arg Glu Glu Leu Met Leu Tyr Arg Arg Arg Leu
305                 310                 315                 320 
Thr Lys Gly Arg Glu Phe Ser Leu Phe Ala Gly Lys Arg Ala Phe Ser
                325                 330                 335     
Gln Lys Pro Ala Gln Ser Arg Lys Phe Tyr His Pro Gln Val Ser Gly
            340                 345                 350         
Glu Ala Arg Thr Arg Thr Pro Leu Glu Ser His Lys Leu Gln Glu Pro
        355                 360                 365             
Ser Val Leu Leu Glu His Gln Trp Pro Pro
    370                 375             


<210> 8308
<211> 540
<212> PRT
<213> Homo sapiens

<400> 8308
Met Ala Ser Gln Glu Phe Glu Val Glu Ala Ile Val Asp Lys Arg Gln
 1               5                  10                  15      
Asp Lys Asn Gly Asn Thr Gln Tyr Leu Val Arg Trp Lys Gly Tyr Asp
            20                  25                  30          
Lys Gln Asp Asp Thr Trp Glu Pro Glu Gln His Leu Met Asn Cys Glu
        35                  40                  45              
Lys Cys Val His Asp Phe Asn Arg Arg Gln Thr Glu Lys Gln Lys Lys
    50                  55                  60                  
Leu Thr Trp Thr Thr Thr Ser Arg Ile Phe Ser Asn Asn Ala Arg Arg
65                  70                  75                  80  
Arg Thr Ser Arg Ser Thr Lys Ala Asn Tyr Ser Lys Asn Ser Pro Lys
                85                  90                  95      
Thr Pro Val Thr Asp Lys His His Arg Ser Lys Asn Arg Lys Leu Phe
            100                 105                 110         
Ala Ala Ser Lys Asn Val Arg Arg Lys Ala Ala Ser Ile Leu Ser Asp
        115                 120                 125             
Thr Lys Asn Met Glu Ile Ile Asn Ser Thr Ile Glu Thr Leu Ala Pro
    130                 135                 140                 
Asp Ser Pro Phe Asp His Lys Thr Val Ser Gly Phe Gln Lys Leu Glu
145                 150                 155                 160 
Lys Leu Asp Pro Ile Ala Ala Asp Gln Gln Asp Thr Val Val Phe Lys
                165                 170                 175     
Val Thr Glu Gly Lys Leu Leu Arg Asp Pro Leu Ser Arg Pro Gly Ala
            180                 185                 190         
Glu Gln Thr Gly Ile Gln Asn Lys Thr Gln Ile His Pro Leu Met Ser
        195                 200                 205             
Gln Met Ser Gly Ser Val Thr Ala Ser Met Ala Thr Gly Ser Ala Thr
    210                 215                 220                 
Arg Lys Gly Ile Val Val Leu Ile Asp Pro Leu Ala Ala Asn Gly Thr
225                 230                 235                 240 
Thr Asp Met His Thr Ser Val Pro Arg Val Lys Gly Gly Gln Arg Asn
                245                 250                 255     
Ile Thr Asp Asp Ser Arg Asp Gln Pro Phe Ile Lys Lys Met His Phe
            260                 265                 270         
Thr Ile Arg Leu Thr Glu Ser Ala Ser Thr Tyr Arg Asp Ile Val Val
        275                 280                 285             
Lys Lys Glu Asp Gly Phe Thr Gln Ile Val Leu Ser Thr Arg Ser Thr
    290                 295                 300                 
Glu Lys Asn Ala Leu Asn Thr Glu Val Ile Lys Glu Ile Val Asn Ala
305                 310                 315                 320 
Leu Asn Ser Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Phe Ser Ala
                325                 330                 335     
Ala Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Gly Tyr Phe Val Lys
            340                 345                 350         
His Leu Arg Asn Asn Arg Asn Thr Ala Ser Leu Glu Met Val Asp Thr
        355                 360                 365             
Ile Lys Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile Val
    370                 375                 380                 
Val Ser Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu Pro
385                 390                 395                 400 
Leu Cys Asp Leu Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr Pro
                405                 410                 415     
Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Ser Ile Thr Phe
            420                 425                 430         
Pro Lys Met Met Gly Lys Ala Ser Ala Asn Glu Met Leu Ile Ala Gly
        435                 440                 445             
Arg Lys Leu Thr Ala Arg Glu Ala Cys Ala Lys Gly Leu Val Ser Gln
    450                 455                 460                 
Val Phe Leu Thr Gly Thr Phe Thr Gln Glu Val Met Ile Gln Ile Lys
465                 470                 475                 480 
Glu Leu Ala Ser Tyr Asn Pro Ile Val Leu Glu Glu Cys Lys Ala Leu
                485                 490                 495     
Val Arg Cys Asn Ile Lys Leu Glu Leu Glu Gln Ala Asn Glu Arg Glu
            500                 505                 510         
Cys Glu Val Leu Arg Lys Ile Trp Ser Ser Ala Gln Gly Ile Glu Ser
        515                 520                 525             
Met Leu Lys Tyr Val Glu Asn Lys Ile Asp Glu Phe
    530                 535                 540 


<210> 8309
<211> 554
<212> PRT
<213> Homo sapiens

<400> 8309
Met Ala Ser Gln Glu Phe Glu Val Glu Ala Ile Val Asp Lys Arg Gln
 1               5                  10                  15      
Asp Lys Asn Gly Asn Thr Gln Tyr Leu Val Arg Trp Lys Gly Tyr Asp
            20                  25                  30          
Lys Gln Asp Asp Thr Trp Glu Pro Glu Gln His Leu Met Asn Cys Glu
        35                  40                  45              
Lys Cys Val His Asp Phe Asn Arg Arg Gln Thr Glu Lys Gln Lys Lys
    50                  55                  60                  
Leu Thr Trp Thr Thr Thr Ser Arg Ile Phe Ser Asn Asn Ala Arg Arg
65                  70                  75                  80  
Arg Thr Ser Arg Ser Thr Lys Ala Asn Tyr Ser Lys Asn Ser Pro Lys
                85                  90                  95      
Thr Pro Val Thr Asp Lys His His Arg Ser Lys Asn Arg Lys Leu Phe
            100                 105                 110         
Ala Ala Ser Lys Asn Val Arg Arg Lys Ala Ala Ser Ile Leu Ser Asp
        115                 120                 125             
Thr Lys Asn Met Glu Ile Ile Asn Ser Thr Ile Glu Thr Leu Ala Pro
    130                 135                 140                 
Asp Ser Pro Phe Asp His Lys Thr Val Ser Gly Phe Gln Lys Leu Glu
145                 150                 155                 160 
Lys Leu Asp Pro Ile Ala Ala Asp Gln Gln Asp Thr Val Val Phe Lys
                165                 170                 175     
Val Thr Glu Gly Lys Leu Leu Arg Asp Pro Leu Ser Arg Pro Gly Ala
            180                 185                 190         
Glu Gln Thr Gly Ile Gln Asn Lys Thr Gln Ile His Pro Leu Met Ser
        195                 200                 205             
Gln Met Ser Gly Ser Val Thr Ala Ser Met Ala Thr Gly Ser Ala Thr
    210                 215                 220                 
Arg Lys Gly Ile Val Val Leu Ile Asp Pro Leu Ala Ala Asn Gly Thr
225                 230                 235                 240 
Thr Asp Met His Thr Ser Val Pro Arg Val Lys Gly Gly Gln Arg Asn
                245                 250                 255     
Ile Thr Asp Asp Ser Arg Asp Gln Pro Phe Ile Lys Lys Met His Phe
            260                 265                 270         
Thr Ile Arg Leu Thr Glu Ser Ala Ser Thr Tyr Arg Asp Ile Val Val
        275                 280                 285             
Lys Lys Glu Asp Gly Phe Thr Gln Ile Val Leu Ser Thr Arg Ser Thr
    290                 295                 300                 
Glu Lys Asn Ala Leu Asn Thr Glu Val Ile Lys Glu Ile Val Asn Ala
305                 310                 315                 320 
Leu Asn Ser Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Phe Ser Ala
                325                 330                 335     
Ala Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Gly Tyr Phe Val Lys
            340                 345                 350         
His Leu Arg Asn Asn Arg Asn Thr Ala Ser Leu Glu Met Val Asp Thr
        355                 360                 365             
Ile Lys Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile Val
    370                 375                 380                 
Val Ser Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu Pro
385                 390                 395                 400 
Leu Cys Asp Leu Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr Pro
                405                 410                 415     
Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Ser Ile Thr Phe
            420                 425                 430         
Pro Lys Met Met Gly Lys Ala Ser Ala Asn Glu Met Leu Ile Ala Gly
        435                 440                 445             
Arg Lys Leu Thr Ala Arg Glu Ala Cys Ala Lys Gly Leu Val Ser Gln
    450                 455                 460                 
Val Phe Leu Thr Gly Thr Phe Thr Gln Glu Val Met Ile Gln Ile Lys
465                 470                 475                 480 
Glu Leu Ala Ser Tyr Asn Pro Ile Val Leu Glu Glu Cys Lys Ala Leu
                485                 490                 495     
Val Arg Cys Asn Ile Lys Leu Glu Leu Glu Gln Ala Asn Glu Arg Glu
            500                 505                 510         
Cys Glu Val Leu Arg Lys Ile Trp Ser Ser Ala Gln Gly Ile Glu Ser
        515                 520                 525             
Met Leu Lys Ile Pro Leu Leu Gly Tyr Lys Ala Ala Phe Pro Pro Arg
    530                 535                 540                 
Lys Thr Gln Asn Asp Gln Arg Trp Cys Pro
545                 550                 


<210> 8310
<211> 329
<212> PRT
<213> Homo sapiens

<400> 8310
Met Ala Thr Gly Gln Lys Leu Met Arg Ala Val Arg Val Phe Glu Phe
 1               5                  10                  15      
Gly Gly Pro Glu Val Leu Lys Leu Arg Ser Asp Ile Ala Val Pro Ile
            20                  25                  30          
Pro Lys Asp His Gln Val Leu Ile Lys Val His Ala Cys Gly Val Asn
        35                  40                  45              
Pro Val Glu Thr Tyr Ile Arg Ser Gly Thr Tyr Ser Arg Lys Pro Leu
    50                  55                  60                  
Leu Pro Tyr Thr Pro Gly Ser Asp Val Ala Gly Val Ile Glu Ala Val
65                  70                  75                  80  
Gly Asp Asn Ala Ser Ala Phe Lys Lys Gly Asp Arg Val Phe Thr Ser
                85                  90                  95      
Ser Thr Ile Ser Gly Gly Tyr Ala Glu Tyr Ala Leu Ala Ala Asp His
            100                 105                 110         
Thr Val Tyr Lys Leu Pro Glu Lys Leu Asp Phe Lys Gln Gly Ala Ala
        115                 120                 125             
Ile Gly Ile Pro Tyr Phe Thr Ala Tyr Arg Ala Leu Ile His Ser Ala
    130                 135                 140                 
Cys Val Lys Ala Gly Glu Ser Val Leu Val His Gly Ala Ser Gly Gly
145                 150                 155                 160 
Val Gly Leu Ala Ala Cys Gln Ile Ala Arg Ala Tyr Gly Leu Lys Ile
                165                 170                 175     
Leu Gly Thr Ala Gly Thr Glu Glu Gly Gln Lys Ile Val Leu Gln Asn
            180                 185                 190         
Gly Ala His Glu Val Phe Asn His Arg Glu Val Asn Tyr Ile Asp Lys
        195                 200                 205             
Ile Lys Lys Tyr Val Gly Glu Lys Gly Ile Asp Ile Ile Ile Glu Met
    210                 215                 220                 
Leu Ala Asn Val Asn Leu Ser Lys Asp Leu Ser Leu Leu Ser His Gly
225                 230                 235                 240 
Gly Arg Val Ile Val Val Gly Ser Arg Gly Thr Ile Glu Ile Asn Pro
                245                 250                 255     
Arg Asp Thr Met Ala Lys Glu Ser Ser Ile Ile Gly Val Thr Leu Phe
            260                 265                 270         
Ser Ser Thr Lys Glu Glu Phe Gln Gln Tyr Ala Ala Ala Leu Gln Ala
        275                 280                 285             
Gly Met Glu Ile Gly Trp Leu Lys Pro Val Ile Gly Ser Gln Tyr Pro
    290                 295                 300                 
Leu Glu Lys Val Ala Glu Ala His Glu Asn Ile Ile His Gly Ser Gly
305                 310                 315                 320 
Ala Thr Gly Lys Met Ile Leu Leu Leu
                325                 


<210> 8311
<211> 895
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 295, 530, 545, 664, 666, 697
<223> Xaa = Any Amino Acid

<400> 8311
Met Gln Gly Pro Leu Thr Phe Met Asp Val Ala Ile Glu Phe Ser Leu
 1               5                  10                  15      
Glu Glu Trp Gln Cys Leu Asp Thr Ala Gln Arg Asn Val Tyr Arg His
            20                  25                  30          
Val Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Ala Leu Cys Ser
        35                  40                  45              
Arg Phe Ala Gln Asp Leu Trp Leu Glu Gln Asn Ile Lys Asp Ser Phe
    50                  55                  60                  
Gln Lys Val Thr Leu Ser Arg Tyr Gly Lys Tyr Gly His Lys Asn Leu
65                  70                  75                  80  
Gln Leu Arg Lys Gly Cys Lys Ser Val Asp Glu Cys Lys Gly His Gln
                85                  90                  95      
Gly Gly Phe Asn Gly Leu Asn Gln Cys Leu Lys Ile Thr Thr Ser Lys
            100                 105                 110         
Ile Phe Gln Cys Asn Lys Tyr Val Lys Val Met His Lys Phe Ser Asn
        115                 120                 125             
Ser Asn Arg His Lys Ile Arg His Thr Glu Asn Lys His Phe Arg Cys
    130                 135                 140                 
Lys Glu Cys Asp Lys Ser Leu Cys Met Leu Ser Arg Leu Thr Gln His
145                 150                 155                 160 
Lys Lys Ile His Thr Arg Glu Asn Phe Tyr Lys Cys Glu Glu Cys Gly
                165                 170                 175     
Lys Thr Phe Asn Trp Ser Thr Asn Leu Ser Lys Pro Lys Lys Ile His
            180                 185                 190         
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Val Cys Gly Lys Ala Phe His
        195                 200                 205             
Gln Ser Ser Ile Leu Thr Lys His Lys Ile Ile Arg Thr Gly Glu Lys
    210                 215                 220                 
Pro Tyr Lys Cys Ala His Cys Gly Lys Ala Phe Lys Gln Ser Ser His
225                 230                 235                 240 
Leu Thr Arg His Lys Ile Ile His Thr Glu Glu Lys Pro Tyr Lys Cys
                245                 250                 255     
Glu Gln Cys Gly Lys Val Phe Lys Gln Ser Pro Thr Leu Thr Lys His
            260                 265                 270         
Gln Ile Ile Tyr Thr Gly Glu Glu Pro Tyr Lys Cys Glu Glu Cys Gly
        275                 280                 285             
Lys Ala Phe Asn Leu Ser Xaa Gln Leu Thr Glu His Lys Lys Ile Tyr
    290                 295                 300                 
Thr Arg Glu Lys Ala Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
305                 310                 315                 320 
Gln Phe Ser Thr Leu Ile Thr His Lys Ile Ile His Ser Gly Glu Lys
                325                 330                 335     
Pro His Lys Cys Glu Glu Cys Gly Arg Ala Phe Asn Gln Ser Ala Lys
            340                 345                 350         
Leu Thr Glu His Lys Leu Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
        355                 360                 365             
Lys Glu Cys Gly Lys Ala Phe His Arg Tyr Ser Ile Leu Ser Thr His
    370                 375                 380                 
Lys Lys Ile His Thr Gly Glu Lys Pro His Lys Cys Gly Glu Cys Gly
385                 390                 395                 400 
Lys Ala Phe Asn Trp Ser Ser Thr Leu Ile Thr His Lys Ile Ile His
                405                 410                 415     
Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
            420                 425                 430         
Gln Ser Ser His Leu Met Arg His Lys Lys Ile His Ser Lys Glu Lys
        435                 440                 445             
Pro Tyr Lys Cys Glu Gln Cys Gly Lys Val Phe Lys Lys Ser Ser Thr
    450                 455                 460                 
Leu Thr Ala His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
465                 470                 475                 480 
Glu Glu Cys Gly Lys Gly Phe Ser Gln Leu Ser Asn Leu Thr Lys His
                485                 490                 495     
Lys Lys Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
            500                 505                 510         
Ile Ser Phe Asn Gln Phe Ser Gln Leu Ala Ile His Lys Met Ile His
        515                 520                 525             
Thr Xaa Met Lys Pro Tyr Lys Cys Glu Arg Cys Gly Ser Cys Phe Asn
    530                 535                 540                 
Xaa Phe Ser Asn Phe Thr Met His Lys Lys Ile Gln Thr Gly Glu Lys
545                 550                 555                 560 
Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Val Ser Thr
                565                 570                 575     
Leu Thr Ile His Lys Ile Ile Tyr Thr Gly Ala Lys Pro Trp Lys Phe
            580                 585                 590         
Lys Glu Cys Gly Lys Thr Tyr Asn Pro Gln Asn Phe Leu Thr Pro Lys
        595                 600                 605             
Ile His Ala Gly Glu Lys His His Lys Cys Glu Lys Phe Gly Lys Phe
    610                 615                 620                 
Phe Asn Lys Ser Ser Thr Leu Ser Ala His Asn Ile Ile His Thr Gly
625                 630                 635                 640 
Glu Lys Pro His Lys Tyr Glu Glu Cys Gly Asn Ala Phe Asn Gln Phe
                645                 650                 655     
Ser Asn Leu Thr Lys Gln Asn Xaa Tyr Xaa Lys Cys Tyr Lys Pro Glu
            660                 665                 670         
Lys Cys Glu Asn Asp Phe Thr Lys Pro Ser Asn Phe Ser Lys His Lys
        675                 680                 685             
Gly Asn His Thr Gly Lys Lys Leu Xaa Lys Cys Glu Glu Cys Asp Lys
    690                 695                 700                 
Ala Phe Lys Trp Leu Ser His Leu Ile Val Gly Lys Ile Ile His Thr
705                 710                 715                 720 
Gly Arg Asn Ser Gln Lys Cys Glu Glu Tyr Gly Lys Thr Leu Ile Pro
                725                 730                 735     
Ile Pro Tyr Cys Thr Gly Lys His Leu Tyr Phe Arg Lys Cys Cys Thr
            740                 745                 750         
Asp Ile Lys Asn Val Glu Lys Pro Leu Ile Cys Ala Tyr Ile Leu Phe
        755                 760                 765             
Asn Ile Arg Asp Arg Leu Arg Asp Ser Arg Ser Val Leu Leu Gly Ser
    770                 775                 780                 
Leu Arg Pro Arg Ser Ser Trp Ser Leu Gly Ser Ala Thr Ser Asp Thr
785                 790                 795                 800 
Asp Val Ser Glu Ser Ser Met Pro Ile Trp Thr Ser Pro Gly Glu Val
                805                 810                 815     
Asn Leu Gly Leu Leu Val Thr Arg Thr Gly Leu Pro Leu Arg Lys Glu
            820                 825                 830         
Thr Leu Pro Gly Cys Ala His Asp Ser Arg Pro Gly Arg Asn Gly Gln
        835                 840                 845             
Lys Glu Lys Gly Gly Val Leu Thr Gln Arg Leu Pro Asn Trp Thr Gly
    850                 855                 860                 
Val Ala Ala Ala Ala Val Thr Trp Arg Gln Val Thr Gly Arg Asn Gly
865                 870                 875                 880 
Pro Met Ala Val Glu Glu Lys Pro Asp Leu Thr Glu Gly Glu Ala
                885                 890                 895 


<210> 8312
<211> 1233
<212> PRT
<213> Homo sapiens

<400> 8312
Thr Thr Ser Thr Thr Ser Ala Ser Thr Thr Ser Thr Ile Ser Pro Leu
 1               5                  10                  15      
Thr Thr Ser Thr Thr Ser Ala Pro Ile Thr Ser Met Pro Ser Gly Pro
            20                  25                  30          
Gly Thr Thr Pro Ser Pro Val Pro Thr Thr Ser Thr Thr Ser Ala Pro
        35                  40                  45              
Thr Thr Ser Thr Thr Ser Gly Pro Gly Thr Thr Pro Ser Pro Val Pro
    50                  55                  60                  
Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Ser
65                  70                  75                  80  
Thr Ala Ser Thr Thr Ser Gly Pro Gly Thr Thr Pro Ser Pro Val Pro
                85                  90                  95      
Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Ser
            100                 105                 110         
Thr Ala Ser Thr Thr Ser Gly Pro Gly Thr Ser Leu Ser Pro Val Pro
        115                 120                 125             
Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Gly Pro
    130                 135                 140                 
Gly Thr Thr Pro Ser Pro Val Pro Thr Thr Ser Thr Thr Ser Ala Pro
145                 150                 155                 160 
Thr Thr Ser Thr Thr Ser Gly Pro Gly Thr Thr Pro Ser Pro Val Pro
                165                 170                 175     
Thr Thr Ser Thr Thr Pro Val Ser Lys Thr Ser Thr Ser His Leu Ser
            180                 185                 190         
Val Ser Lys Thr Thr His Ser Gln Pro Val Thr Ser Asp Cys His Pro
        195                 200                 205             
Leu Cys Ala Trp Thr Lys Trp Phe Asp Val Asp Phe Pro Ser Pro Gly
    210                 215                 220                 
Pro His Gly Gly Asp Lys Glu Thr Tyr Asn Asn Ile Ile Arg Ser Gly
225                 230                 235                 240 
Glu Lys Ile Cys Arg Arg Pro Glu Glu Ile Thr Arg Leu Gln Cys Arg
                245                 250                 255     
Ala Glu Ser His Pro Glu Val Asn Ile Glu His Leu Gly Gln Val Val
            260                 265                 270         
Gln Cys Ser Arg Glu Glu Gly Leu Val Cys Arg Asn Gln Asp Gln Gln
        275                 280                 285             
Gly Pro Phe Lys Met Cys Leu Asn Tyr Glu Val Arg Val Leu Cys Cys
    290                 295                 300                 
Glu Thr Pro Arg Gly Cys Pro Val Thr Ser Val Thr Pro Tyr Gly Thr
305                 310                 315                 320 
Ser Pro Thr Asn Ala Leu Tyr Pro Ser Leu Ser Thr Ser Met Val Ser
                325                 330                 335     
Ala Ser Val Ala Ser Thr Ser Val Ala Ser Ser Ser Val Ala Ser Ser
            340                 345                 350         
Ser Val Ala Tyr Ser Thr Gln Thr Cys Phe Cys Asn Val Ala Asp Arg
        355                 360                 365             
Leu Tyr Pro Ala Gly Ser Thr Ile Tyr Arg His Arg Asp Leu Ala Gly
    370                 375                 380                 
His Cys Tyr Tyr Ala Leu Cys Ser Gln Asp Cys Gln Val Val Arg Gly
385                 390                 395                 400 
Val Asp Ser Asp Cys Pro Ser Thr Thr Leu Pro Pro Ala Pro Ala Thr
                405                 410                 415     
Ser Pro Ser Ile Ser Thr Ser Glu Pro Val Thr Glu Leu Gly Cys Pro
            420                 425                 430         
Asn Ala Val Pro Pro Arg Lys Lys Gly Glu Thr Trp Ala Thr Pro Asn
        435                 440                 445             
Cys Ser Glu Ala Thr Cys Glu Gly Asn Asn Val Ile Ser Leu Ser Pro
    450                 455                 460                 
Arg Thr Cys Pro Arg Val Glu Lys Pro Thr Cys Ala Asn Gly Tyr Pro
465                 470                 475                 480 
Ala Val Lys Val Ala Asp Gln Asp Gly Cys Cys His His Tyr Gln Cys
                485                 490                 495     
Gln Cys Val Cys Ser Gly Trp Gly Asp Pro His Tyr Ile Thr Phe Asp
            500                 505                 510         
Gly Thr Tyr Tyr Thr Phe Leu Asp Asn Cys Thr Tyr Val Leu Val Gln
        515                 520                 525             
Gln Ile Val Pro Val Tyr Gly His Phe Arg Val Leu Val Asp Asn Tyr
    530                 535                 540                 
Phe Cys Gly Ala Glu Asp Gly Leu Ser Cys Pro Arg Ser Ile Ile Leu
545                 550                 555                 560 
Glu Tyr His Gln Asp Arg Val Val Leu Thr Arg Lys Pro Val His Gly
                565                 570                 575     
Val Met Thr Asn Glu Ile Ile Phe Asn Asn Lys Val Val Ser Pro Gly
            580                 585                 590         
Phe Arg Lys Asn Gly Ile Val Val Ser Arg Ile Gly Val Lys Met Tyr
        595                 600                 605             
Ala Thr Ile Pro Glu Leu Gly Val Gln Val Met Phe Ser Gly Leu Ile
    610                 615                 620                 
Phe Ser Val Glu Val Pro Phe Ser Lys Phe Ala Asn Asn Thr Glu Gly
625                 630                 635                 640 
Gln Cys Gly Thr Cys Thr Asn Asp Arg Lys Asp Glu Cys Arg Thr Pro
                645                 650                 655     
Arg Gly Thr Val Val Ala Ser Cys Ser Glu Met Ser Gly Leu Trp Asn
            660                 665                 670         
Val Ser Ile Pro Asp Gln Pro Ala Cys His Arg Pro His Pro Thr Pro
        675                 680                 685             
Thr Thr Val Gly Pro Thr Thr Val Gly Ser Thr Thr Val Gly Pro Thr
    690                 695                 700                 
Thr Val Gly Ser Thr Thr Val Gly Pro Thr Thr Pro Pro Ala Pro Cys
705                 710                 715                 720 
Leu Pro Ser Pro Ile Cys His Leu Ile Leu Ser Lys Val Phe Glu Pro
                725                 730                 735     
Cys His Thr Val Ile Pro Pro Leu Leu Phe Tyr Glu Gly Cys Val Phe
            740                 745                 750         
Asp Arg Cys His Met Thr Asp Leu Asp Val Val Cys Ser Ser Leu Glu
        755                 760                 765             
Leu Tyr Ala Ala Leu Cys Ala Ser His Asp Ile Cys Ile Asp Trp Arg
    770                 775                 780                 
Gly Arg Thr Gly His Met Cys Pro Phe Thr Cys Pro Ala Asp Lys Val
785                 790                 795                 800 
Tyr Gln Pro Cys Gly Pro Ser Asn Pro Ser Tyr Cys Tyr Gly Asn Asp
                805                 810                 815     
Ser Ala Ser Leu Gly Ala Leu Arg Glu Ala Gly Pro Ile Thr Glu Gly
            820                 825                 830         
Cys Phe Cys Pro Glu Gly Met Thr Leu Phe Ser Thr Ser Ala Gln Val
        835                 840                 845             
Cys Val Pro Thr Gly Cys Pro Arg Cys Leu Gly Pro His Gly Glu Pro
    850                 855                 860                 
Val Lys Val Gly His Thr Val Gly Met Asp Cys Gln Glu Cys Thr Cys
865                 870                 875                 880 
Glu Ala Ala Thr Trp Thr Leu Thr Cys Arg Pro Lys Leu Cys Pro Leu
                885                 890                 895     
Pro Pro Ala Cys Pro Leu Pro Gly Phe Val Pro Val Pro Ala Ala Pro
            900                 905                 910         
Gln Ala Gly Gln Cys Cys Pro Gln Tyr Ser Cys Ala Cys Asn Thr Ser
        915                 920                 925             
Arg Cys Pro Ala Pro Val Gly Cys Pro Glu Gly Ala Arg Ala Ile Pro
    930                 935                 940                 
Thr Tyr Gln Glu Gly Ala Cys Cys Pro Val Gln Asn Cys Ser Trp Thr
945                 950                 955                 960 
Val Cys Ser Ile Asn Gly Thr Leu Tyr Gln Pro Gly Ala Val Val Ser
                965                 970                 975     
Ser Ser Leu Cys Glu Thr Cys Arg Cys Glu Leu Pro Gly Gly Pro Pro
            980                 985                 990         
Ser Asp Ala Phe Val Val Ser Cys Glu Thr Gln Ile Cys Asn Thr His
        995                 1000                1005            
Cys Pro Val Gly Phe Glu Tyr Gln Glu Gln Ser Gly Gln Cys Cys Gly
    1010                1015                1020                
Thr Cys Val Gln Val Ala Cys Val Thr Asn Thr Ser Lys Ser Pro Ala
1025                1030                1035                1040
His Leu Phe Tyr Pro Gly Glu Thr Trp Ser Asp Ala Gly Asn His Cys
                1045                1050                1055    
Val Thr His Gln Cys Glu Lys His Gln Asp Gly Leu Val Val Val Thr
            1060                1065                1070        
Thr Lys Lys Ala Cys Pro Pro Leu Ser Cys Ser Leu Asp Glu Ala Arg
        1075                1080                1085            
Met Ser Lys Asp Gly Cys Cys Arg Phe Cys Pro Leu Pro Pro Pro Pro
    1090                1095                1100                
Tyr Gln Asn Gln Ser Thr Cys Ala Val Tyr His Arg Ser Leu Ile Ile
1105                1110                1115                1120
Gln Gln Gln Gly Cys Ser Ser Ser Glu Pro Val Arg Leu Ala Tyr Cys
                1125                1130                1135    
Arg Gly Asn Cys Gly Asp Ser Ser Ser Met Tyr Ser Leu Glu Gly Asn
            1140                1145                1150        
Thr Val Glu His Arg Cys Gln Cys Cys Gln Glu Leu Arg Thr Ser Leu
        1155                1160                1165            
Arg Asn Val Thr Leu His Cys Thr Asp Gly Ser Ser Arg Ala Phe Ser
    1170                1175                1180                
Tyr Thr Glu Val Glu Glu Cys Gly Cys Met Gly Arg Arg Cys Pro Ala
1185                1190                1195                1200
Pro Gly Asp Thr Gln His Ser Glu Glu Ala Glu Pro Glu Pro Ser Gln
                1205                1210                1215    
Glu Ala Glu Ser Gly Ser Trp Glu Arg Gly Val Pro Val Ser Pro Met
            1220                1225                1230        
His
    


<210> 8313
<211> 446
<212> PRT
<213> Homo sapiens

<400> 8313
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30          
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45              
Thr Met Lys Glu Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val
    50                  55                  60                  
Val Asn Gln Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn
65                  70                  75                  80  
Arg Cys His Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu
                85                  90                  95      
Leu Gln Glu Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser
            100                 105                 110         
Thr Ser Ser Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp
        115                 120                 125             
Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile
    130                 135                 140                 
Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile
145                 150                 155                 160 
Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn
                165                 170                 175     
Pro Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp
            180                 185                 190         
Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser
        195                 200                 205             
Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser
    210                 215                 220                 
Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu
225                 230                 235                 240 
Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp
                245                 250                 255     
Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser
            260                 265                 270         
His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp
        275                 280                 285             
Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn
    290                 295                 300                 
Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr
305                 310                 315                 320 
Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys
                325                 330                 335     
Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro
            340                 345                 350         
Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu
        355                 360                 365             
Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser
    370                 375                 380                 
Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro
385                 390                 395                 400 
Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys
                405                 410                 415     
Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val
            420                 425                 430         
Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro
        435                 440                 445     


<210> 8314
<211> 270
<212> PRT
<213> Homo sapiens

<400> 8314
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Asp Leu Asp Ala Gly
            20                  25                  30          
Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser Val Ser Asp
        35                  40                  45              
Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr
    50                  55                  60                  
Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp Asp Glu Asp
65                  70                  75                  80  
Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser
                85                  90                  95      
His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp
            100                 105                 110         
Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn
        115                 120                 125             
Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr
    130                 135                 140                 
Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys
145                 150                 155                 160 
Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro
                165                 170                 175     
Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu
            180                 185                 190         
Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser
        195                 200                 205             
Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro
    210                 215                 220                 
Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys
225                 230                 235                 240 
Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val
                245                 250                 255     
Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro
            260                 265                 270 


<210> 8315
<211> 296
<212> PRT
<213> Homo sapiens

<400> 8315
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Asp Leu Asp Ala Gly
            20                  25                  30          
Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser Val Ser Asp
        35                  40                  45              
Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr
    50                  55                  60                  
Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp Asp Glu Val
65                  70                  75                  80  
Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr Asp Ser Phe
                85                  90                  95      
Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys Cys Thr Ser
            100                 105                 110         
Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn Arg Cys Trp
        115                 120                 125             
Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly
    130                 135                 140                 
Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu
145                 150                 155                 160 
Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn Asp Ser Arg
                165                 170                 175     
Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln
            180                 185                 190         
Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile
        195                 200                 205             
Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr
    210                 215                 220                 
Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile
225                 230                 235                 240 
Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val
                245                 250                 255     
His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys
            260                 265                 270         
Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln
        275                 280                 285             
Met Ile Val Leu Thr Tyr Phe Pro
    290                 295     


<210> 8316
<211> 243
<212> PRT
<213> Homo sapiens

<400> 8316
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30          
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45              
Thr Met Lys Glu Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn
    50                  55                  60                  
Pro Pro Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn
65                  70                  75                  80  
Trp Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys
                85                  90                  95      
Ala Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro
            100                 105                 110         
Asp Cys Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu
        115                 120                 125             
Glu Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu
    130                 135                 140                 
Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln
145                 150                 155                 160 
Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu
                165                 170                 175     
Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile
            180                 185                 190         
Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly
        195                 200                 205             
His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn
    210                 215                 220                 
Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr
225                 230                 235                 240 
Tyr Phe Pro
            


<210> 8317
<211> 218
<212> PRT
<213> Homo sapiens

<400> 8317
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Asp Tyr Trp Lys Cys
            20                  25                  30          
Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn Arg
        35                  40                  45              
Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys Asp
    50                  55                  60                  
Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala
65                  70                  75                  80  
Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn Asp
                85                  90                  95      
Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln Ala
            100                 105                 110         
Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser
        115                 120                 125             
Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg Glu
    130                 135                 140                 
Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu Asn
145                 150                 155                 160 
Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys
                165                 170                 175     
Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys Ala
            180                 185                 190         
Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln Pro
        195                 200                 205             
Ile Gln Met Ile Val Leu Thr Tyr Phe Pro
    210                 215             


<210> 8318
<211> 436
<212> PRT
<213> Homo sapiens

<400> 8318
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30          
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45              
Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys
    50                  55                  60                  
Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp
65                  70                  75                  80  
Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His
                85                  90                  95      
Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln
            100                 105                 110         
Gln Glu Glu Asn Ser Asp Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg
        115                 120                 125             
His Lys Ser Asp Ser Ile Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu
    130                 135                 140                 
Cys Val Ile Arg Glu Ile Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser
145                 150                 155                 160 
Thr Gly Thr Pro Ser Asn Pro Asp Leu Asp Ala Gly Val Ser Glu His
                165                 170                 175     
Ser Gly Asp Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser Val
            180                 185                 190         
Glu Phe Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu
        195                 200                 205             
Glu Gly Gln Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val Thr
    210                 215                 220                 
Val Tyr Gln Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro
225                 230                 235                 240 
Glu Ile Ser Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met
                245                 250                 255     
Asn Pro Pro Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu
            260                 265                 270         
Asn Trp Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu
        275                 280                 285             
Lys Ala Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val
    290                 295                 300                 
Pro Asp Cys Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val
305                 310                 315                 320 
Glu Glu Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser
                325                 330                 335     
Glu Asp Tyr Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser
            340                 345                 350         
Gln Glu Asp Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu
        355                 360                 365             
Glu Ser Val Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val
    370                 375                 380                 
Ile Cys Gln Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr
385                 390                 395                 400 
Gly His Leu Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg
                405                 410                 415     
Asn Lys Pro Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu
            420                 425                 430         
Thr Tyr Phe Pro
        435     


<210> 8319
<211> 491
<212> PRT
<213> Homo sapiens

<400> 8319
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30          
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45              
Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys
    50                  55                  60                  
Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp
65                  70                  75                  80  
Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His
                85                  90                  95      
Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln
            100                 105                 110         
Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His
        115                 120                 125             
Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu
    130                 135                 140                 
Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser
145                 150                 155                 160 
Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser
                165                 170                 175     
Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser
            180                 185                 190         
Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu
        195                 200                 205             
Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu
    210                 215                 220                 
Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser
225                 230                 235                 240 
Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser
                245                 250                 255     
Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp
            260                 265                 270         
Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr
        275                 280                 285             
Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys
    290                 295                 300                 
Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn
305                 310                 315                 320 
Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys
                325                 330                 335     
Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln
            340                 345                 350         
Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn
        355                 360                 365             
Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln
    370                 375                 380                 
Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser
385                 390                 395                 400 
Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg
                405                 410                 415     
Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu
            420                 425                 430         
Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly
        435                 440                 445             
Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys
    450                 455                 460                 
Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln
465                 470                 475                 480 
Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro
                485                 490     


<210> 8320
<211> 430
<212> PRT
<213> Homo sapiens

<400> 8320
Met Thr Lys Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys
 1               5                  10                  15      
Ser Asn Asp Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val
            20                  25                  30          
Lys Glu His Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val
        35                  40                  45              
Val Asn Gln Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn
    50                  55                  60                  
Arg Cys His Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu
65                  70                  75                  80  
Leu Gln Glu Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser
                85                  90                  95      
Thr Ser Ser Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp
            100                 105                 110         
Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile
        115                 120                 125             
Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile
    130                 135                 140                 
Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn
145                 150                 155                 160 
Pro Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp
                165                 170                 175     
Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser
            180                 185                 190         
Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser
        195                 200                 205             
Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu
    210                 215                 220                 
Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp
225                 230                 235                 240 
Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser
                245                 250                 255     
His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp
            260                 265                 270         
Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn
        275                 280                 285             
Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr
    290                 295                 300                 
Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys
305                 310                 315                 320 
Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro
                325                 330                 335     
Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu
            340                 345                 350         
Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser
        355                 360                 365             
Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro
    370                 375                 380                 
Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys
385                 390                 395                 400 
Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val
                405                 410                 415     
Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro
            420                 425                 430 


<210> 8321
<211> 321
<212> PRT
<213> Homo sapiens

<400> 8321
Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr
 1               5                  10                  15      
Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro
            20                  25                  30          
Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr
        35                  40                  45              
Thr Met Lys Glu Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly Asp
    50                  55                  60                  
Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe Glu
65                  70                  75                  80  
Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln
                85                  90                  95      
Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr Gln
            100                 105                 110         
Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser
        115                 120                 125             
Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro Pro
    130                 135                 140                 
Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu
145                 150                 155                 160 
Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys
                165                 170                 175     
Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp Cys
            180                 185                 190         
Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu Asn
        195                 200                 205             
Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr
    210                 215                 220                 
Ser Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp
225                 230                 235                 240 
Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser Val
                245                 250                 255     
Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln
            260                 265                 270         
Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu
        275                 280                 285             
Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro
    290                 295                 300                 
Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe
305                 310                 315                 320 
Pro
    


<210> 8322
<211> 418
<212> PRT
<213> Homo sapiens

<400> 8322
Met Pro Gly His Asp Ala Glu Pro Gln His Gln Ser Gln Lys Val Gln
 1               5                  10                  15      
Asp Trp Met Leu Ala Ala Asp Thr Val Ser Met Ala Glu Leu Gln Cys
            20                  25                  30          
Thr Gln Leu Asp Leu Glu Arg Lys Leu Lys Leu Asn Glu Asn Ala Ile
        35                  40                  45              
Ser Arg Leu Gln Ala Asn Gln Lys Ser Val Leu Val Ser Val Ser Glu
    50                  55                  60                  
Val Lys Ala Val Ala Glu Met Gln Phe Gly Glu Leu Leu Ala Ala Val
65                  70                  75                  80  
Arg Lys Ala Gln Ala Asn Val Met Leu Phe Leu Glu Glu Lys Glu Gln
                85                  90                  95      
Ala Ala Leu Ser Gln Ala Asn Gly Ile Lys Ala His Leu Glu Tyr Arg
            100                 105                 110         
Ser Ala Glu Met Glu Lys Ser Lys Gln Glu Leu Glu Thr Met Ala Ala
        115                 120                 125             
Ile Ser Asn Thr Val Gln Phe Leu Glu Glu Tyr Cys Lys Phe Lys Asn
    130                 135                 140                 
Thr Glu Asp Ile Thr Phe Pro Ser Val Tyr Ile Gly Leu Lys Asp Lys
145                 150                 155                 160 
Leu Ser Gly Ile Arg Lys Val Ile Thr Glu Ser Thr Val His Leu Ile
                165                 170                 175     
Gln Leu Leu Glu Asn Tyr Lys Lys Lys Leu Gln Glu Phe Ser Lys Glu
            180                 185                 190         
Glu Glu Tyr Asp Ile Arg Thr Gln Val Ser Ala Ile Val Gln Arg Lys
        195                 200                 205             
Tyr Trp Thr Ser Lys Pro Glu Pro Ser Thr Arg Glu Gln Phe Leu Gln
    210                 215                 220                 
Tyr Val His Asp Ile Thr Phe Asp Pro Asp Thr Ala His Lys Tyr Leu
225                 230                 235                 240 
Arg Leu Gln Glu Glu Asn Arg Lys Val Thr Asn Thr Thr Pro Trp Glu
                245                 250                 255     
His Pro Tyr Pro Asp Leu Pro Ser Arg Phe Leu His Trp Arg Gln Val
            260                 265                 270         
Leu Ser Gln Gln Ser Leu Tyr Leu His Arg Tyr Tyr Phe Glu Val Glu
        275                 280                 285             
Ile Phe Gly Ala Gly Thr Tyr Val Gly Leu Thr Cys Lys Gly Ile Asp
    290                 295                 300                 
Gln Lys Gly Glu Glu Arg Ser Ser Cys Ile Ser Gly Asn Asn Phe Ser
305                 310                 315                 320 
Trp Ser Leu Gln Trp Asn Gly Lys Glu Phe Thr Ala Trp Tyr Ser Asp
                325                 330                 335     
Met Glu Thr Pro Leu Lys Ala Gly Pro Phe Trp Arg Leu Gly Val Tyr
            340                 345                 350         
Ile Asp Phe Pro Gly Gly Ile Leu Ser Phe Tyr Gly Val Glu Tyr Asp
        355                 360                 365             
Ser Met Thr Leu Val His Lys Phe Ala Cys Lys Phe Ser Glu Pro Val
    370                 375                 380                 
Tyr Ala Ala Phe Trp Leu Ser Lys Lys Glu Asn Ala Ile Arg Ile Val
385                 390                 395                 400 
Asp Leu Gly Glu Glu Pro Glu Lys Pro Ala Pro Ser Leu Val Gly Thr
                405                 410                 415     
Ala Pro
        


<210> 8323
<211> 708
<212> PRT
<213> Homo sapiens

<400> 8323
Met Ser Phe Lys Asp Lys Asp Glu Arg Ile Ser Cys Leu Glu Ala Tyr
 1               5                  10                  15      
Val Thr Leu Thr Ser Lys Ser Ser Arg Phe Thr Asp Glu Thr Glu Ile
            20                  25                  30          
Leu Lys Met Ser Gln Arg His Ser Gly Gln Ala Gly Thr Glu Ala Gly
        35                  40                  45              
Asn Gly Ala Asp Ser Pro Pro Ile Val Asn Ser Lys Tyr Ser Thr Phe
    50                  55                  60                  
Arg Asp Phe Cys Ser Thr Ser Ser Phe Gln Asp Ser Gly Tyr Asn Glu
65                  70                  75                  80  
Leu Lys Ser Cys Ser Phe Asp Asn Ile Asp Lys Glu Tyr Leu Gly Lys
                85                  90                  95      
Lys Glu Lys Gly Pro Thr Leu Leu Tyr Glu His Pro Glu Thr Ser Gly
            100                 105                 110         
Leu Gly Leu Thr His Pro Leu Glu Ser Pro Thr Gln Lys Lys Lys Cys
        115                 120                 125             
Ile Leu Pro Arg Lys Glu Lys Asp Lys Thr Pro Glu Leu Cys Glu Thr
    130                 135                 140                 
Pro Lys Ile Ser Gly Lys Lys Cys Leu Pro Arg Arg Arg Leu Asn Val
145                 150                 155                 160 
Ser Phe Ala Leu Leu Lys Gly Asp Phe Glu Ser Gln Asn Ser Ser Leu
                165                 170                 175     
Glu Ser Ser Ile Ser Gln Val Ile Asn Leu Glu Lys Asn Ile Pro Ser
            180                 185                 190         
Ser Ala Ser Gly Phe Ser Arg Ala Asn Asn Phe Ser Pro Leu Val Thr
        195                 200                 205             
Ser Thr Leu Lys Thr Glu Glu Val Thr Ser Cys Ser Gln Lys Leu Arg
    210                 215                 220                 
Leu Asn Phe Ser Gln Gln Lys Thr Ser Thr Ile Asp Asp Ser Lys Asp
225                 230                 235                 240 
Asp Cys Ser Leu Phe Glu Val Glu Cys Ile Ser Pro Ile Gln Gly Asn
                245                 250                 255     
Asn Phe Lys Asp Ser Ile Thr His Asp Phe Ser Asp Ser Ser Leu Cys
            260                 265                 270         
Ile Asn Asp Glu Asn Ala Cys Pro Glu Leu Leu Gly Ser Ser Val Ser
        275                 280                 285             
Gly Thr Thr Cys Gly Thr Asp Glu Asp Ile Phe Val Thr Pro Ile Ser
    290                 295                 300                 
Asn Leu Val Ala Asn Ile Arg Phe Asn Ala Ser Gln Ile Leu Ser Pro
305                 310                 315                 320 
Ser Pro Glu Val Arg Gly Ser Ile Ser Thr Pro Glu Asp Ser Gly Phe
                325                 330                 335     
Asn Ser Leu Ser Leu Glu Lys Ser Glu Asp Ser Leu Ser Asp Gln Glu
            340                 345                 350         
Gly Ser Phe Gln Glu Leu Leu Gln Lys His Lys Gly Thr Pro Lys Val
        355                 360                 365             
Gly Asp Thr Ile Arg Lys Thr Arg His Leu Gly Arg Ser Arg Arg Leu
    370                 375                 380                 
Ser Thr Leu Arg Glu Gln Ser Ser Gln Ser Glu Thr Glu Glu Glu Lys
385                 390                 395                 400 
Gln Ile Val His Pro Asp Ser Glu Lys Arg Ala Ala Ala Ala Ser Ala
                405                 410                 415     
Ile Ser Glu Gly Gln Leu Ser Ser Asp Glu Ser Gly Asp Leu Thr Phe
            420                 425                 430         
Ser Leu Lys Asn Leu Ser Lys Thr Pro Ala Leu Gln Leu Val His Glu
        435                 440                 445             
Leu Phe Met Lys Ser Lys Arg Lys Arg Leu Gln Glu Asn Ser Gly His
    450                 455                 460                 
Glu Phe Leu Glu Gln Gly Asp Gly Glu Lys Ile Ala Val Leu Gln Cys
465                 470                 475                 480 
Ile Leu Ala Gly Leu Ile Gly Lys Lys Met Gly Ile Glu Lys Leu Asp
                485                 490                 495     
Ile Leu Thr Glu Leu Lys Tyr Arg Asn Leu Lys His Ile Leu Ala Met
            500                 505                 510         
Val Leu Glu Ser Leu Thr Ala Glu Ser Leu Cys Ser Val Trp Lys Val
        515                 520                 525             
Ser Arg Asn Trp Arg Glu Ile Val Val Gln Asp Lys Asn Ala Asn Arg
    530                 535                 540                 
Arg Arg Lys Phe Tyr Ile Thr Gln Leu Lys Thr Asp Ser Glu Gly Ala
545                 550                 555                 560 
Val Leu Asn Val Glu Asp Ala Ala Thr Arg Leu Gln Leu Leu Asn Arg
                565                 570                 575     
Ser Ala Leu Arg Ser Val Gln Ala Gln Ala Arg Ile Pro Gly Ser Gln
            580                 585                 590         
Arg Glu Gln Gly Ser Thr Leu Ser Pro Trp Gly Glu Val Leu Thr Pro
        595                 600                 605             
Leu Ala Ser Ser Ser Val Thr His Leu Ser Ser Lys Gln Glu Glu Tyr
    610                 615                 620                 
Val Lys Val Ala Lys Thr Leu Phe Thr Asp Glu Ala Leu Lys Pro Cys
625                 630                 635                 640 
Pro Arg Cys Gln Ser Pro Ala Lys Tyr Gln Pro Tyr Lys Lys Arg Gly
                645                 650                 655     
Leu Cys Ser Arg Thr Ala Cys Gly Phe Asp Phe Cys Val Leu Cys Leu
            660                 665                 670         
Cys Ala Tyr His Gly Ser Glu Glu Cys Ser Arg Gly Ala Ala Lys Pro
        675                 680                 685             
Arg Asn Arg Lys Asp Ala Leu Pro Gly Ser Ala Gln Ser Lys Arg Asn
    690                 695                 700                 
Leu Lys Arg Leu
705             


<210> 8324
<211> 875
<212> PRT
<213> Homo sapiens

<400> 8324
Met Glu Lys Leu His Gln Cys Tyr Trp Lys Ser Gly Glu Pro Gln Ser
 1               5                  10                  15      
Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu
            20                  25                  30          
Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala
        35                  40                  45              
Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp
    50                  55                  60                  
Asn Asn Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala
65                  70                  75                  80  
Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr
                85                  90                  95      
Leu Glu Asn Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys
            100                 105                 110         
Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu
        115                 120                 125             
Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu
    130                 135                 140                 
Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala
145                 150                 155                 160 
Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu
                165                 170                 175     
Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu
            180                 185                 190         
Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu
        195                 200                 205             
Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu
    210                 215                 220                 
Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg
225                 230                 235                 240 
Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe
                245                 250                 255     
Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr
            260                 265                 270         
Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile
        275                 280                 285             
Ile Gly Met Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met
    290                 295                 300                 
Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala
305                 310                 315                 320 
Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile
                325                 330                 335     
Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile
            340                 345                 350         
Ser Asn Glu Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile
        355                 360                 365             
Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val
    370                 375                 380                 
Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro
385                 390                 395                 400 
Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu
                405                 410                 415     
Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu
            420                 425                 430         
Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu
        435                 440                 445             
Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr
    450                 455                 460                 
Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys
465                 470                 475                 480 
Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp
                485                 490                 495     
Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser
            500                 505                 510         
Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg
        515                 520                 525             
Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala
    530                 535                 540                 
Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu
545                 550                 555                 560 
Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln
                565                 570                 575     
Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr
            580                 585                 590         
Asp Glu Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr
        595                 600                 605             
Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr
    610                 615                 620                 
Asn Asn Cys Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys
625                 630                 635                 640 
Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro
                645                 650                 655     
Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val
            660                 665                 670         
Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe
        675                 680                 685             
Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro
    690                 695                 700                 
Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr
705                 710                 715                 720 
Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly
                725                 730                 735     
Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro
            740                 745                 750         
Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln
        755                 760                 765             
Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser
    770                 775                 780                 
Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu
785                 790                 795                 800 
Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro
                805                 810                 815     
Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro
            820                 825                 830         
Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu
        835                 840                 845             
Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys
    850                 855                 860                 
Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu
865                 870                 875 


<210> 8325
<211> 852
<212> PRT
<213> Homo sapiens

<400> 8325
Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln
 1               5                  10                  15      
Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala
            20                  25                  30          
Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys
        35                  40                  45              
Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro
    50                  55                  60                  
Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala
65                  70                  75                  80  
Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys Lys Gly Ala Arg
                85                  90                  95      
Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu Lys Val Tyr Glu
            100                 105                 110         
Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg
        115                 120                 125             
Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe
    130                 135                 140                 
Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Ala
145                 150                 155                 160 
Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser
                165                 170                 175     
Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Ile Gly
            180                 185                 190         
Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu Gly Pro Asp Asp
        195                 200                 205             
Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Thr Arg Leu Leu
    210                 215                 220                 
Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu
225                 230                 235                 240 
Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Ser Arg
                245                 250                 255     
Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Gly Met Glu Asn Arg Asn
            260                 265                 270         
Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys
        275                 280                 285             
Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu
    290                 295                 300                 
Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe
305                 310                 315                 320 
Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg
                325                 330                 335     
Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu
            340                 345                 350         
Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu Val Asp Thr Asn
        355                 360                 365             
His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu
    370                 375                 380                 
Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro
385                 390                 395                 400 
Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys
                405                 410                 415     
Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn
            420                 425                 430         
Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr
        435                 440                 445             
Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val
    450                 455                 460                 
Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser
465                 470                 475                 480 
Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu
                485                 490                 495     
Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp
            500                 505                 510         
Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu
        515                 520                 525             
Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu
    530                 535                 540                 
Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe
545                 550                 555                 560 
Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser Thr Lys Leu Phe
                565                 570                 575     
Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile
            580                 585                 590         
Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val
        595                 600                 605             
His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr
    610                 615                 620                 
Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys
625                 630                 635                 640 
Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr
                645                 650                 655     
Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp
            660                 665                 670         
Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys
        675                 680                 685             
Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu
    690                 695                 700                 
Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu
705                 710                 715                 720 
Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile
                725                 730                 735     
Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu
            740                 745                 750         
Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile Arg Glu Phe Trp
        755                 760                 765             
Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln
    770                 775                 780                 
Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu
785                 790                 795                 800 
Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr
                805                 810                 815     
Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys
            820                 825                 830         
Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly
        835                 840                 845             
Phe Gly Met Leu
    850         


<210> 8326
<211> 872
<212> PRT
<213> Homo sapiens

<400> 8326
Met Ala Thr Ala Cys Lys Arg Ser Gly Glu Pro Gln Ser Asp Asp Ile
 1               5                  10                  15      
Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg
            20                  25                  30          
Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn
        35                  40                  45              
Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala
    50                  55                  60                  
Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys
65                  70                  75                  80  
Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn
                85                  90                  95      
Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys
            100                 105                 110         
Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu
        115                 120                 125             
Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser
    130                 135                 140                 
Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu
145                 150                 155                 160 
Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys
                165                 170                 175     
Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys
            180                 185                 190         
Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser
        195                 200                 205             
Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu
    210                 215                 220                 
Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr
225                 230                 235                 240 
Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala
                245                 250                 255     
Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn
            260                 265                 270         
Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Gly Met
        275                 280                 285             
Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro
    290                 295                 300                 
Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys
305                 310                 315                 320 
Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met
                325                 330                 335     
Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu
            340                 345                 350         
Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala
        355                 360                 365             
Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu
    370                 375                 380                 
Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu
385                 390                 395                 400 
Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn
                405                 410                 415     
Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys
            420                 425                 430         
Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn
        435                 440                 445             
Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe
    450                 455                 460                 
Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile
465                 470                 475                 480 
Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile
                485                 490                 495     
Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln
            500                 505                 510         
Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His
        515                 520                 525             
Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn
    530                 535                 540                 
Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln
545                 550                 555                 560 
Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val
                565                 570                 575     
Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser
            580                 585                 590         
Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln
        595                 600                 605             
Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys
    610                 615                 620                 
Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly
625                 630                 635                 640 
Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr
                645                 650                 655     
Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp
            660                 665                 670         
Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro
        675                 680                 685             
Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn
    690                 695                 700                 
Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn
705                 710                 715                 720 
Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met
                725                 730                 735     
Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile
            740                 745                 750         
Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu
        755                 760                 765             
Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile
    770                 775                 780                 
Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg
785                 790                 795                 800 
Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly
                805                 810                 815     
Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu
            820                 825                 830         
Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu
        835                 840                 845             
Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr
    850                 855                 860                 
Tyr Ala Lys Gly Phe Gly Met Leu
865                 870         


<210> 8327
<211> 852
<212> PRT
<213> Homo sapiens

<400> 8327
Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln
 1               5                  10                  15      
Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala
            20                  25                  30          
Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys
        35                  40                  45              
Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro
    50                  55                  60                  
Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala
65                  70                  75                  80  
Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys Lys Gly Ala Arg
                85                  90                  95      
Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu Lys Val Tyr Glu
            100                 105                 110         
Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg
        115                 120                 125             
Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe
    130                 135                 140                 
Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Ala
145                 150                 155                 160 
Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser
                165                 170                 175     
Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Ile Gly
            180                 185                 190         
Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu Gly Pro Asp Asp
        195                 200                 205             
Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Thr Arg Leu Leu
    210                 215                 220                 
Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu
225                 230                 235                 240 
Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Ser Arg
                245                 250                 255     
Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Arg Asn
            260                 265                 270         
Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys
        275                 280                 285             
Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu
    290                 295                 300                 
Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe
305                 310                 315                 320 
Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg
                325                 330                 335     
Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu
            340                 345                 350         
Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu Val Asp Thr Asn
        355                 360                 365             
His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu
    370                 375                 380                 
Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro
385                 390                 395                 400 
Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys
                405                 410                 415     
Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn
            420                 425                 430         
Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr
        435                 440                 445             
Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val
    450                 455                 460                 
Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser
465                 470                 475                 480 
Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu
                485                 490                 495     
Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp
            500                 505                 510         
Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu
        515                 520                 525             
Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu
    530                 535                 540                 
Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe
545                 550                 555                 560 
Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser Thr Lys Leu Phe
                565                 570                 575     
Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile
            580                 585                 590         
Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val
        595                 600                 605             
His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr
    610                 615                 620                 
Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys
625                 630                 635                 640 
Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr
                645                 650                 655     
Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp
            660                 665                 670         
Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys
        675                 680                 685             
Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu
    690                 695                 700                 
Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu
705                 710                 715                 720 
Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile
                725                 730                 735     
Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu
            740                 745                 750         
Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile Arg Glu Phe Trp
        755                 760                 765             
Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln
    770                 775                 780                 
Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu
785                 790                 795                 800 
Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr
                805                 810                 815     
Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys
            820                 825                 830         
Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly
        835                 840                 845             
Phe Gly Met Leu
    850         


<210> 8328
<211> 1348
<212> PRT
<213> Homo sapiens

<400> 8328
Gly Ala Lys Asp Leu Val Cys Ser Lys Met Ser Arg Ala Lys Asp Ala
 1               5                  10                  15      
Val Ser Ser Gly Val Ala Ser Val Val Asp Val Ala Lys Gly Val Val
            20                  25                  30          
Gln Gly Gly Leu Asp Thr Thr Arg Ser Ala Leu Thr Gly Thr Lys Glu
        35                  40                  45              
Ala Val Ser Ser Gly Val Thr Gly Ala Met Asp Met Ala Lys Gly Ala
    50                  55                  60                  
Val Gln Gly Gly Leu Asp Thr Ser Lys Ala Val Leu Thr Gly Thr Lys
65                  70                  75                  80  
Asp Thr Val Ser Thr Gly Leu Thr Gly Ala Val Asn Val Ala Lys Gly
                85                  90                  95      
Thr Val Gln Ala Gly Val Asp Thr Thr Lys Thr Val Leu Thr Gly Thr
            100                 105                 110         
Lys Asp Thr Val Thr Thr Gly Val Met Gly Ala Val Asn Leu Ala Lys
        115                 120                 125             
Gly Thr Val Gln Thr Gly Val Glu Thr Ser Lys Ala Val Leu Thr Gly
    130                 135                 140                 
Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Asn Val Ala
145                 150                 155                 160 
Arg Gly Ser Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val Leu Thr
                165                 170                 175     
Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Ser Ala Met Asn Val
            180                 185                 190         
Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val Leu
        195                 200                 205             
Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Met Asn
    210                 215                 220                 
Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val
225                 230                 235                 240 
Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Met
                245                 250                 255     
Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Thr Lys Thr
            260                 265                 270         
Val Leu Thr Gly Thr Lys Asn Thr Val Cys Ser Gly Val Thr Gly Ala
        275                 280                 285             
Val Asn Leu Ala Lys Glu Ala Ile Gln Gly Gly Leu Asp Thr Thr Lys
    290                 295                 300                 
Ser Met Val Met Gly Thr Lys Asp Thr Met Ser Thr Gly Leu Thr Gly
305                 310                 315                 320 
Ala Ala Asn Val Ala Lys Gly Ala Met Gln Thr Gly Leu Asn Thr Thr
                325                 330                 335     
Gln Asn Ile Ala Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr
            340                 345                 350         
Gly Ala Met Asn Leu Ala Arg Gly Thr Ile Gln Thr Gly Val Asp Thr
        355                 360                 365             
Thr Lys Ile Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val
    370                 375                 380                 
Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val Gln Gly Gly Leu Asp
385                 390                 395                 400 
Thr Thr Lys Ser Val Leu Thr Gly Thr Lys Asp Ala Val Ser Thr Gly
                405                 410                 415     
Leu Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val
            420                 425                 430         
Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser
        435                 440                 445             
Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly Ala Val Gln Gly Gly
    450                 455                 460                 
Leu Asp Thr Thr Lys Ser Val Val Ile Gly Thr Lys Asp Thr Met Ser
465                 470                 475                 480 
Thr Gly Leu Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val Gln Thr
                485                 490                 495     
Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val
            500                 505                 510         
Thr Thr Gly Leu Val Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln
        515                 520                 525             
Thr Gly Met Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Thr
    530                 535                 540                 
Ile Tyr Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly Ala Val
545                 550                 555                 560 
Gln Thr Gly Leu Lys Thr Thr Gln Asn Ile Ala Thr Gly Thr Lys Asn
                565                 570                 575     
Thr Phe Gly Ser Gly Val Thr Gly Ala Val Asn Val Ala Lys Gly Ala
            580                 585                 590         
Val Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly Thr Lys
        595                 600                 605             
Asp Thr Val Thr Thr Gly Leu Met Gly Ala Val Asn Val Ala Lys Gly
    610                 615                 620                 
Thr Val Gln Thr Ser Val Asp Thr Thr Lys Thr Val Leu Thr Gly Thr
625                 630                 635                 640 
Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Ala Asn Val Ala Lys
                645                 650                 655     
Gly Ala Val Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly
            660                 665                 670         
Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Val Asn Val Ala
        675                 680                 685             
Lys Gly Ala Val Gln Thr Gly Leu Lys Thr Thr Gln Asn Ile Ala Thr
    690                 695                 700                 
Gly Thr Lys Asn Thr Leu Gly Ser Gly Val Thr Gly Ala Ala Asn Val
705                 710                 715                 720 
Ala Lys Gly Ala Val Gln Gly Gly Leu Asp Thr Thr Lys Ser Val Leu
                725                 730                 735     
Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Asn
            740                 745                 750         
Leu Ala Lys Gly Thr Val Gln Thr Gly Met Asp Thr Thr Lys Thr Val
        755                 760                 765             
Leu Thr Gly Thr Lys Asp Ala Val Cys Ser Gly Val Thr Gly Ala Ala
    770                 775                 780                 
Asn Val Ala Lys Gly Ala Val Gln Thr Gly Val Asp Thr Ala Lys Thr
785                 790                 795                 800 
Val Leu Thr Gly Thr Lys Asp Thr Val Thr Thr Gly Leu Met Gly Ala
                805                 810                 815     
Val Asn Val Ala Lys Gly Thr Val Gln Thr Ser Val Asp Thr Thr Lys
            820                 825                 830         
Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly
        835                 840                 845             
Ala Ala Asn Val Ala Lys Gly Ala Val Gln Gly Gly Leu Asp Thr Thr
    850                 855                 860                 
Lys Ser Val Leu Thr Gly Thr Lys Asp Thr Val Ser Thr Gly Leu Thr
865                 870                 875                 880 
Gly Ala Val Asn Leu Ala Lys Gly Thr Val Gln Thr Gly Val Asp Thr
                885                 890                 895     
Ser Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val
            900                 905                 910         
Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val Asp
        915                 920                 925             
Thr Ala Lys Thr Val Leu Ser Gly Ala Lys Asp Ala Val Thr Thr Gly
    930                 935                 940                 
Val Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val
945                 950                 955                 960 
Asp Ala Ser Lys Ala Val Leu Met Gly Thr Lys Asp Thr Val Phe Ser
                965                 970                 975     
Gly Val Thr Gly Ala Met Ser Met Ala Lys Gly Ala Val Gln Gly Gly
            980                 985                 990         
Leu Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Ala Val Ser
        995                 1000                1005            
Ala Gly Leu Met Gly Ser Gly Asn Val Ala Thr Gly Ala Thr His Thr
    1010                1015                1020                
Gly Leu Ser Thr Phe Gln Asn Trp Leu Pro Ser Thr Pro Ala Thr Ser
1025                1030                1035                1040
Trp Gly Gly Leu Thr Ser Ser Arg Thr Thr Asp Asn Gly Gly Glu Gln
                1045                1050                1055    
Thr Ala Leu Ser Pro Gln Glu Ala Pro Phe Ser Gly Ile Ser Thr Pro
            1060                1065                1070        
Pro Asp Val Leu Ser Val Gly Pro Glu Pro Ala Trp Glu Ala Ala Ala
        1075                1080                1085            
Thr Thr Lys Gly Leu Ala Thr Asp Val Ala Thr Phe Thr Gln Gly Ala
    1090                1095                1100                
Ala Pro Gly Arg Glu Asp Thr Gly Leu Leu Thr Thr Thr His Gly Pro
1105                1110                1115                1120
Glu Glu Ala Pro Arg Leu Ala Met Leu Gln Asn Glu Leu Glu Gly Leu
                1125                1130                1135    
Gly Asp Ile Phe His Pro Met Asn Ala Glu Glu Gln Ala Gln Leu Ala
            1140                1145                1150        
Ala Ser Gln Pro Gly Pro Lys Val Leu Ser Ala Glu Gln Gly Ser Tyr
        1155                1160                1165            
Phe Val Arg Leu Gly Asp Leu Gly Pro Ser Phe Arg Gln Arg Ala Phe
    1170                1175                1180                
Glu His Ala Val Ser His Leu Gln His Gly Gln Phe Gln Ala Arg Asp
1185                1190                1195                1200
Thr Leu Ala Gln Leu Gln Asp Cys Phe Arg Leu Ile Glu Lys Ala Gln
                1205                1210                1215    
Gln Ala Pro Glu Gly Gln Pro Arg Leu Asp Gln Gly Ser Gly Ala Ser
            1220                1225                1230        
Ala Glu Asp Ala Ala Val Gln Glu Glu Arg Asp Ala Gly Val Leu Ser
        1235                1240                1245            
Arg Val Cys Gly Leu Leu Arg Gln Leu His Thr Ala Tyr Ser Gly Leu
    1250                1255                1260                
Val Ser Ser Leu Gln Gly Leu Pro Ala Glu Leu Gln Gln Pro Val Gly
1265                1270                1275                1280
Arg Ala Arg His Ser Leu Cys Glu Leu Tyr Gly Ile Val Ala Ser Ala
                1285                1290                1295    
Gly Ser Val Glu Glu Leu Pro Ala Glu Arg Leu Val Gln Ser Arg Glu
            1300                1305                1310        
Gly Val His Gln Ala Trp Gln Gly Leu Glu Gln Leu Leu Glu Gly Leu
        1315                1320                1325            
Gln His Asn Pro Pro Leu Ser Trp Leu Val Gly Pro Phe Ala Leu Pro
    1330                1335                1340                
Ala Gly Gly Gln
1345            


<210> 8329
<211> 526
<212> PRT
<213> Homo sapiens

<400> 8329
Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys Glu
 1               5                  10                  15      
Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly Asn
            20                  25                  30          
Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly Pro
        35                  40                  45              
Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe Asp
    50                  55                  60                  
Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly Ala
65                  70                  75                  80  
Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys Ala
                85                  90                  95      
Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg Phe
            100                 105                 110         
Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp Pro
        115                 120                 125             
Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp Leu
    130                 135                 140                 
Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu Phe
145                 150                 155                 160 
Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu Lys
                165                 170                 175     
Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser Leu
            180                 185                 190         
His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly His
        195                 200                 205             
Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn Ala
    210                 215                 220                 
Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln Gly
225                 230                 235                 240 
Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu Asp
                245                 250                 255     
Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly Lys
            260                 265                 270         
Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln Ala
        275                 280                 285             
Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro His
    290                 295                 300                 
Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg Asn
305                 310                 315                 320 
Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro Ser
                325                 330                 335     
Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln Gly
            340                 345                 350         
Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro Asn
        355                 360                 365             
Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala Asn
    370                 375                 380                 
Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly Ala
385                 390                 395                 400 
Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro Ser
                405                 410                 415     
Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe Asn
            420                 425                 430         
Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val Asn
        435                 440                 445             
Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala Gly
    450                 455                 460                 
His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys Asn
465                 470                 475                 480 
Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu Leu
                485                 490                 495     
Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe Val
            500                 505                 510         
Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu
        515                 520                 525     


<210> 8330
<211> 841
<212> PRT
<213> Homo sapiens

<400> 8330
Met Thr Ala Thr Thr Trp Leu Lys Glu Gly Pro Pro Ala His Lys Leu
 1               5                  10                  15      
Glu Met Pro Arg Gln Pro Asp Cys Gln Glu Cys Arg Gly Thr Glu Gln
            20                  25                  30          
Ala Ala Glu Pro Leu Ala Lys Glu Ala Cys Asp Leu Cys Ser Asp Phe
        35                  40                  45              
Ser Asp Glu Glu Pro Val Gly Ala Thr Gly Ile Lys Thr Ala Lys Asn
    50                  55                  60                  
Lys Ala Pro Asp Ser Ser Lys Ala Ser Ser Ser Pro Gly Gln Leu Thr
65                  70                  75                  80  
Leu Leu Gln Cys Gly Phe Ser Lys Leu Leu Glu Thr Lys Cys Lys Ala
                85                  90                  95      
Val Glu Asp Ser Asp Gly Asn Thr Ala Ser Asp Asp Glu Ser Ser Asp
            100                 105                 110         
Glu Gln Pro Thr Cys Leu Ser Thr Glu Ala Lys Asp Ala Gly Cys Glu
        115                 120                 125             
Lys Asn Gln Asp Ser Leu Gly Thr Ser Lys His Gln Lys Leu Asp Asn
    130                 135                 140                 
Ile Leu Asn Pro Lys Glu Lys His Ile Phe Tyr Lys Ser Glu Lys Ile
145                 150                 155                 160 
Leu Glu Gln Asn Ile Ser Ser Lys Ser Asp Glu Lys Lys Ile Lys Asn
                165                 170                 175     
Thr Asp Lys His Cys Ile Leu Gln Asn Val Thr Glu Ser Glu Asp Ser
            180                 185                 190         
Asp Val Ile Cys Pro Thr Gln Tyr Thr Thr Glu Arg Phe Pro Asp Asn
        195                 200                 205             
Ser Ile Arg Phe Lys Pro Pro Leu Glu Gly Ser Glu Asp Ser Glu Thr
    210                 215                 220                 
Glu His Thr Val Lys Thr Arg Asn Asn Asp Asn Ser Arg Asn Thr Asp
225                 230                 235                 240 
Asp Lys Arg Asn Gly Ile Ile Ser Lys Lys Leu Ser Pro Glu Asn Thr
                245                 250                 255     
Thr Leu Lys Ser Ile Leu Lys Arg Lys Gly Thr Ser Asp Ile Ser Asp
            260                 265                 270         
Glu Ser Asp Asp Ile Glu Ile Ser Ser Lys Ser Arg Val Arg Lys Arg
        275                 280                 285             
Ala Ser Ser Leu Arg Phe Lys Arg Ile Lys Glu Thr Lys Lys Glu Leu
    290                 295                 300                 
His Asn Ser Pro Lys Thr Met Asn Lys Thr Asn Gln Val Tyr Ala Ala
305                 310                 315                 320 
Asn Glu Asp His Asn Ser Gln Phe Ile Asp Asp Tyr Ser Ser Ser Asp
                325                 330                 335     
Glu Ser Leu Ser Val Ser His Phe Ser Phe Ser Lys Gln Ser His Arg
            340                 345                 350         
Pro Arg Thr Ile Arg Asp Arg Thr Ser Phe Ser Ser Lys Leu Pro Ser
        355                 360                 365             
His Asn Lys Lys Asn Ser Thr Phe Ile Pro Arg Lys Pro Met Lys Cys
    370                 375                 380                 
Ser Asn Glu Lys Val Val Asn Gln Glu Gln Ser Tyr Glu Ser Met Asp
385                 390                 395                 400 
Lys Phe Leu Asp Gly Val Gln Glu Val Ala Tyr Ile His Ser Asn Gln
                405                 410                 415     
Asn Val Ile Gly Ser Ser Lys Ala Glu Asn His Met Ser Arg Trp Ala
            420                 425                 430         
Ala His Asp Val Phe Glu Leu Lys Gln Phe Ser Gln Leu Pro Ala Asn
        435                 440                 445             
Ile Ala Val Cys Ser Ser Lys Thr Tyr Lys Glu Lys Val Asp Ala Asp
    450                 455                 460                 
Thr Leu Pro His Thr Lys Lys Gly Gln Gln Pro Ser Glu Gly Ser Ile
465                 470                 475                 480 
Ser Leu Pro Leu Tyr Ile Ser Asn Pro Val Asn Gln Lys Lys Lys Lys
                485                 490                 495     
Val Tyr His Thr Asn Gln Thr Thr Phe Ile Ile Gly Glu Thr Pro Lys
            500                 505                 510         
Gly Ile Arg Arg Lys Gln Phe Glu Glu Met Ala Ser Tyr Phe Asn Ser
        515                 520                 525             
Ser Ser Val Asn Glu Phe Ala Lys His Ile Thr Asn Ala Thr Ser Glu
    530                 535                 540                 
Glu Arg Gln Lys Met Leu Arg Asp Phe Tyr Ala Ser Gln Tyr Pro Glu
545                 550                 555                 560 
Val Lys Glu Phe Phe Val Asp Ser Val Ser Gln Phe Asn Asn Ser Ser
                565                 570                 575     
Phe Glu Lys Gly Glu Gln Arg Thr Arg Lys Lys Ser Asp Lys Arg Glu
            580                 585                 590         
Ser Leu Ile Lys Pro Arg Leu Ser Asp Ser Glu Thr Leu Ser Phe Lys
        595                 600                 605             
Asp Ser Thr Asn Lys Ile Ser Gln Val Cys Ser Leu Lys Thr Tyr Lys
    610                 615                 620                 
Arg Lys Ser Val Lys Phe Gln Asn His Ile Ser Tyr Arg Glu Glu Val
625                 630                 635                 640 
Phe Phe Asn Asp Ala Glu Thr Lys Lys Ser Pro Val Ser Ser Thr Gln
                645                 650                 655     
Glu Ile Asp Ser Gly Lys Asn Ser Gln Ala Ser Glu Asp Thr Val Thr
            660                 665                 670         
Ser Arg Ser Leu Asn Ser Glu Ser Glu Thr Arg Glu Arg Arg Leu Glu
        675                 680                 685             
Asn Thr Met Lys Asp Gln Gln Asp Leu Thr Arg Thr Gly Ile Ser Arg
    690                 695                 700                 
Lys Glu Pro Leu Leu Lys Leu Glu Asn Lys Lys Ile Glu Asn Pro Val
705                 710                 715                 720 
Leu Glu Asn Thr Ser Val Ile Ser Leu Leu Gly Asp Thr Ser Ile Leu
                725                 730                 735     
Asp Asp Leu Phe Lys Ser His Gly Asn Ser Pro Thr Gln Leu Pro Lys
            740                 745                 750         
Lys Val Leu Ser Gly Pro Met Glu Lys Ala Lys Gln Arg Pro Lys Asp
        755                 760                 765             
Phe Trp Asp Ile Leu Asn Glu Gln Asn Asp Glu Ser Leu Ser Lys Leu
    770                 775                 780                 
Thr Asp Leu Ala Val Ile Glu Thr Leu Cys Glu Lys Ala Pro Leu Ala
785                 790                 795                 800 
Ala Pro Phe Lys Arg Arg Glu Glu Pro Ala Thr Ser Leu Trp Lys Ser
                805                 810                 815     
Asn Glu Lys Phe Leu Trp Lys Lys Phe Ser Pro Ser Asp Thr Asp Glu
            820                 825                 830         
Asn Ala Thr Asn Thr Gln Ser Thr Thr
        835                 840     


<210> 8331
<211> 460
<212> PRT
<213> Homo sapiens

<400> 8331
Met Lys Cys Ser Asn Glu Lys Val Val Asn Gln Glu Gln Ser Tyr Glu
 1               5                  10                  15      
Ser Met Asp Lys Phe Leu Asp Gly Val Gln Glu Val Ala Tyr Ile His
            20                  25                  30          
Ser Asn Gln Asn Val Ile Gly Ser Ser Lys Ala Glu Asn His Met Ser
        35                  40                  45              
Arg Trp Ala Ala His Asp Val Phe Glu Leu Lys Gln Phe Ser Gln Leu
    50                  55                  60                  
Pro Ala Asn Ile Ala Val Cys Ser Ser Lys Thr Tyr Lys Glu Lys Val
65                  70                  75                  80  
Asp Ala Asp Thr Leu Pro His Thr Lys Lys Gly Gln Gln Pro Ser Glu
                85                  90                  95      
Gly Ser Ile Ser Leu Pro Leu Tyr Ile Ser Asn Pro Val Asn Gln Lys
            100                 105                 110         
Lys Lys Lys Val Tyr His Thr Asn Gln Thr Thr Phe Ile Ile Gly Glu
        115                 120                 125             
Thr Pro Lys Gly Ile Arg Arg Lys Gln Phe Glu Glu Met Ala Ser Tyr
    130                 135                 140                 
Phe Asn Ser Ser Ser Val Asn Glu Phe Ala Lys His Ile Thr Asn Ala
145                 150                 155                 160 
Thr Ser Glu Glu Arg Gln Lys Met Leu Arg Asp Phe Tyr Ala Ser Gln
                165                 170                 175     
Tyr Pro Glu Val Lys Glu Phe Phe Val Asp Ser Val Ser Gln Phe Asn
            180                 185                 190         
Asn Ser Ser Phe Glu Lys Gly Glu Gln Arg Thr Arg Lys Lys Ser Asp
        195                 200                 205             
Lys Arg Glu Ser Leu Ile Lys Pro Arg Leu Ser Asp Ser Glu Thr Leu
    210                 215                 220                 
Ser Phe Lys Asp Ser Thr Asn Lys Ile Ser Gln Val Cys Ser Leu Lys
225                 230                 235                 240 
Thr Tyr Lys Arg Lys Ser Val Lys Phe Gln Asn His Ile Ser Tyr Arg
                245                 250                 255     
Glu Glu Val Phe Phe Asn Asp Ala Glu Thr Lys Lys Ser Pro Val Ser
            260                 265                 270         
Ser Thr Gln Glu Ile Asp Ser Gly Lys Asn Ser Gln Ala Ser Glu Asp
        275                 280                 285             
Thr Val Thr Ser Arg Ser Leu Asn Ser Glu Ser Glu Thr Arg Glu Arg
    290                 295                 300                 
Arg Leu Glu Asn Thr Met Lys Asp Gln Gln Asp Leu Thr Arg Thr Gly
305                 310                 315                 320 
Ile Ser Arg Lys Glu Pro Leu Leu Lys Leu Glu Asn Lys Lys Ile Glu
                325                 330                 335     
Asn Pro Val Leu Glu Asn Thr Ser Val Ile Ser Leu Leu Gly Asp Thr
            340                 345                 350         
Ser Ile Leu Asp Asp Leu Phe Lys Ser His Gly Asn Ser Pro Thr Gln
        355                 360                 365             
Leu Pro Lys Lys Val Leu Ser Gly Pro Met Glu Lys Ala Lys Gln Arg
    370                 375                 380                 
Pro Lys Asp Phe Trp Asp Ile Leu Asn Glu Gln Asn Asp Glu Ser Leu
385                 390                 395                 400 
Ser Lys Leu Thr Asp Leu Ala Val Ile Glu Thr Leu Cys Glu Lys Ala
                405                 410                 415     
Pro Leu Ala Ala Pro Phe Lys Arg Arg Glu Glu Pro Ala Thr Ser Leu
            420                 425                 430         
Trp Lys Ser Asn Glu Lys Phe Leu Trp Lys Lys Phe Ser Pro Ser Asp
        435                 440                 445             
Thr Asp Glu Asn Ala Thr Asn Thr Gln Ser Thr Thr
    450                 455                 460 


<210> 8332
<211> 222
<212> PRT
<213> Homo sapiens

<400> 8332
Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala
 1               5                  10                  15      
Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro
            20                  25                  30          
Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln
        35                  40                  45              
Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val
    50                  55                  60                  
Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala
65                  70                  75                  80  
Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile
                85                  90                  95      
Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu
            100                 105                 110         
Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe
        115                 120                 125             
Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly
    130                 135                 140                 
Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln
145                 150                 155                 160 
Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu
                165                 170                 175     
Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln
            180                 185                 190         
Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile
        195                 200                 205             
Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys
    210                 215                 220         


<210> 8333
<211> 222
<212> PRT
<213> Homo sapiens

<400> 8333
Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Val
 1               5                  10                  15      
Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro
            20                  25                  30          
Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln
        35                  40                  45              
Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val
    50                  55                  60                  
Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala
65                  70                  75                  80  
Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile
                85                  90                  95      
Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu
            100                 105                 110         
Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe
        115                 120                 125             
Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly
    130                 135                 140                 
Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln
145                 150                 155                 160 
Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu
                165                 170                 175     
Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln
            180                 185                 190         
Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile
        195                 200                 205             
Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys
    210                 215                 220         


<210> 8334
<211> 262
<212> PRT
<213> Homo sapiens

<400> 8334
Met Lys Lys Ile Arg Gln Val Ile Arg Lys Tyr Asn Tyr Val Ala Met
 1               5                  10                  15      
Asp Thr Glu Phe Pro Gly Val Val Ala Arg Pro Ile Gly Glu Phe Arg
            20                  25                  30          
Ser Asn Ala Asp Tyr Gln Tyr Gln Leu Leu Arg Cys Asn Val Asp Leu
        35                  40                  45              
Leu Lys Ile Ile Gln Leu Gly Leu Thr Phe Met Asn Glu Gln Gly Glu
    50                  55                  60                  
Tyr Pro Pro Gly Thr Ser Thr Trp Gln Phe Asn Phe Lys Phe Asn Leu
65                  70                  75                  80  
Thr Glu Asp Met Tyr Ala Gln Asp Ser Ile Glu Leu Leu Thr Thr Ser
                85                  90                  95      
Gly Ile Gln Phe Lys Lys His Glu Glu Glu Gly Ile Glu Thr Gln Tyr
            100                 105                 110         
Phe Ala Glu Leu Leu Met Thr Ser Gly Val Val Leu Cys Glu Gly Val
        115                 120                 125             
Lys Trp Leu Ser Phe His Ser Gly Tyr Asp Phe Gly Tyr Leu Ile Lys
    130                 135                 140                 
Ile Leu Thr Asn Ser Asn Leu Pro Glu Glu Glu Leu Asp Phe Phe Glu
145                 150                 155                 160 
Ile Leu Arg Leu Phe Phe Pro Val Ile Tyr Asp Val Lys Tyr Leu Met
                165                 170                 175     
Lys Ser Cys Lys Asn Leu Lys Gly Gly Leu Gln Glu Val Ala Glu Gln
            180                 185                 190         
Leu Glu Leu Glu Arg Ile Gly Pro Gln His Gln Ala Gly Ser Asp Ser
        195                 200                 205             
Leu Leu Thr Gly Met Ala Phe Phe Lys Met Arg Glu Met Phe Phe Glu
    210                 215                 220                 
Asp His Ile Asp Asp Ala Lys Tyr Cys Gly His Leu Tyr Gly Leu Gly
225                 230                 235                 240 
Ser Gly Ser Ser Tyr Val Gln Asn Gly Thr Gly Asn Ala Tyr Glu Glu
                245                 250                 255     
Glu Ala Asn Lys Gln Ser
            260         


<210> 8335
<211> 285
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Any Amino Acid

<400> 8335
Met Pro Ala Xaa Thr Val Asp His Ser Gln Arg Ile Cys Glu Val Trp
 1               5                  10                  15      
Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg
            20                  25                  30          
Lys Tyr Asn Tyr Val Ala Met Asp Thr Glu Phe Pro Gly Val Val Ala
        35                  40                  45              
Arg Pro Ile Gly Glu Phe Arg Ser Asn Ala Asp Tyr Gln Tyr Gln Leu
    50                  55                  60                  
Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Thr
65                  70                  75                  80  
Phe Met Asn Glu Gln Gly Glu Tyr Pro Pro Gly Thr Ser Thr Trp Gln
                85                  90                  95      
Phe Asn Phe Lys Phe Asn Leu Thr Glu Asp Met Tyr Ala Gln Asp Ser
            100                 105                 110         
Ile Glu Leu Leu Thr Thr Ser Gly Ile Gln Phe Lys Lys His Glu Glu
        115                 120                 125             
Glu Gly Ile Glu Thr Gln Tyr Phe Ala Glu Leu Leu Met Thr Ser Gly
    130                 135                 140                 
Val Val Leu Cys Glu Gly Val Lys Trp Leu Ser Phe His Ser Gly Tyr
145                 150                 155                 160 
Asp Phe Gly Tyr Leu Ile Lys Ile Leu Thr Asn Ser Asn Leu Pro Glu
                165                 170                 175     
Glu Glu Leu Asp Phe Phe Glu Ile Leu Arg Leu Phe Phe Pro Val Ile
            180                 185                 190         
Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Gly Gly
        195                 200                 205             
Leu Gln Glu Val Ala Glu Gln Leu Glu Leu Glu Arg Ile Gly Pro Gln
    210                 215                 220                 
His Gln Ala Gly Ser Asp Ser Leu Leu Thr Gly Met Ala Phe Phe Lys
225                 230                 235                 240 
Met Arg Glu Met Phe Phe Glu Asp His Ile Asp Asp Ala Lys Tyr Cys
                245                 250                 255     
Gly His Leu Tyr Gly Leu Gly Ser Gly Ser Ser Tyr Val Gln Asn Gly
            260                 265                 270         
Thr Gly Asn Ala Tyr Glu Glu Glu Ala Asn Lys Gln Ser
        275                 280                 285 


<210> 8336
<211> 951
<212> PRT
<213> Homo sapiens

<400> 8336
Met Cys Cys Thr Glu Gly Ser Leu Arg Lys Arg Asp Ser Gln Arg Ala
 1               5                  10                  15      
Pro Glu Ala Val Leu Cys Leu Gln Leu Trp Gln Arg Thr Val Pro Leu
            20                  25                  30          
Asp Thr Leu Lys Gly Leu Gly Thr Cys Phe Pro Ser Gly Pro Glu Leu
        35                  40                  45              
Arg Gly Ala Gly Ile Ala Ala Ala Met Glu Arg Ala Ser Glu Arg Arg
    50                  55                  60                  
Thr Ala Ser Ala Leu Phe Ala Gly Phe Arg Ala Leu Gly Leu Phe Ser
65                  70                  75                  80  
Asn Asp Ile Pro His Val Val Arg Phe Ser Ala Leu Lys Arg Arg Phe
                85                  90                  95      
Tyr Val Thr Thr Cys Val Gly Lys Ser Phe His Thr Tyr Asp Val Gln
            100                 105                 110         
Lys Leu Ser Leu Val Ala Val Ser Asn Ser Val Pro Gln Asp Ile Cys
        115                 120                 125             
Cys Met Ala Ala Asp Gly Arg Leu Val Phe Ala Ala Tyr Gly Asn Val
    130                 135                 140                 
Phe Ser Ala Phe Ala Arg Asn Lys Glu Ile Val His Thr Phe Lys Gly
145                 150                 155                 160 
His Lys Ala Glu Ile His Phe Leu Gln Pro Phe Gly Asp His Ile Ile
                165                 170                 175     
Ser Val Asp Thr Asp Gly Ile Leu Ile Ile Trp His Ile Tyr Ser Glu
            180                 185                 190         
Glu Glu Tyr Leu Gln Leu Thr Phe Asp Lys Ser Val Phe Lys Ile Ser
        195                 200                 205             
Ala Ile Leu His Pro Ser Thr Tyr Leu Asn Lys Ile Leu Leu Gly Ser
    210                 215                 220                 
Glu Gln Gly Ser Leu Gln Leu Trp Asn Val Lys Ser Asn Lys Leu Leu
225                 230                 235                 240 
Tyr Thr Phe Pro Gly Trp Lys Val Gly Val Thr Ala Leu Gln Gln Ala
                245                 250                 255     
Pro Ala Val Asp Val Val Ala Ile Gly Leu Met Ser Gly Gln Val Ile
            260                 265                 270         
Ile His Asn Ile Lys Phe Asn Glu Thr Leu Met Lys Phe Arg Gln Asp
        275                 280                 285             
Trp Gly Pro Ile Thr Ser Ile Ser Phe Arg Thr Asp Gly His Pro Val
    290                 295                 300                 
Met Ala Ala Gly Ser Pro Cys Gly His Ile Gly Leu Trp Asp Leu Glu
305                 310                 315                 320 
Asp Lys Lys Leu Ile Asn Gln Met Arg Asn Ala His Ser Thr Ala Ile
                325                 330                 335     
Ala Gly Leu Thr Phe Leu His Arg Glu Pro Leu Leu Val Thr Asn Gly
            340                 345                 350         
Ala Asp Asn Ala Leu Arg Ile Trp Ile Phe Asp Gly Pro Thr Gly Glu
        355                 360                 365             
Gly Arg Leu Leu Arg Phe Arg Met Gly His Ser Ala Pro Leu Thr Asn
    370                 375                 380                 
Ile Arg Tyr Tyr Gly Gln Asn Gly Gln Gln Ile Leu Ser Ala Ser Gln
385                 390                 395                 400 
Asp Gly Thr Leu Gln Ser Phe Ser Thr Val His Glu Lys Phe Asn Lys
                405                 410                 415     
Ser Leu Gly His Gly Leu Ile Asn Lys Lys Arg Val Lys Arg Lys Gly
            420                 425                 430         
Leu Gln Asn Thr Met Ser Val Arg Leu Pro Pro Ile Thr Lys Phe Ala
        435                 440                 445             
Ala Glu Glu Ala Arg Glu Ser Asp Trp Asp Gly Ile Ile Ala Cys His
    450                 455                 460                 
Gln Gly Lys Leu Ser Cys Ser Thr Trp Asn Tyr Gln Lys Ser Thr Ile
465                 470                 475                 480 
Gly Ala Tyr Phe Leu Lys Pro Lys Glu Leu Lys Lys Asp Asp Ile Thr
                485                 490                 495     
Ala Thr Ala Val Asp Ile Thr Ser Cys Gly Asn Phe Ala Val Ile Gly
            500                 505                 510         
Leu Ser Ser Gly Thr Val Asp Val Tyr Asn Met Gln Ser Gly Ile His
        515                 520                 525             
Arg Gly Ser Phe Gly Lys Asp Gln Ala His Lys Gly Ser Val Arg Gly
    530                 535                 540                 
Val Ala Val Asp Gly Leu Asn Gln Leu Thr Val Thr Thr Gly Ser Glu
545                 550                 555                 560 
Gly Leu Leu Lys Phe Trp Asn Phe Lys Asn Lys Ile Leu Ile His Ser
                565                 570                 575     
Val Ser Leu Ser Ser Ser Pro Asn Ile Met Leu Leu His Arg Asp Ser
            580                 585                 590         
Gly Ile Leu Gly Leu Ala Leu Asp Asp Phe Ser Ile Ser Val Leu Asp
        595                 600                 605             
Ile Glu Thr Arg Lys Ile Val Arg Glu Phe Ser Gly His Gln Gly Gln
    610                 615                 620                 
Ile Asn Asp Met Ala Phe Ser Pro Asp Gly Arg Trp Leu Ile Ser Ala
625                 630                 635                 640 
Ala Met Asp Cys Ser Ile Arg Thr Trp Asp Leu Pro Ser Gly Cys Leu
                645                 650                 655     
Ile Asp Cys Phe Leu Leu Asp Ser Ala Pro Leu Asn Val Ser Met Ser
            660                 665                 670         
Pro Thr Gly Asp Phe Leu Ala Thr Ser His Val Asp His Leu Gly Ile
        675                 680                 685             
Tyr Leu Trp Ser Asn Ile Ser Leu Tyr Ser Val Val Ser Leu Arg Pro
    690                 695                 700                 
Leu Pro Ala Asp Tyr Val Pro Ser Ile Val Met Leu Pro Gly Thr Cys
705                 710                 715                 720 
Gln Thr Gln Asp Val Glu Val Ser Glu Glu Thr Val Glu Pro Ser Asp
                725                 730                 735     
Glu Leu Ile Glu Tyr Asp Ser Pro Glu Gln Leu Asn Glu Gln Leu Val
            740                 745                 750         
Thr Leu Ser Leu Leu Pro Glu Ser Arg Trp Lys Asn Leu Leu Asn Leu
        755                 760                 765             
Asp Val Ile Lys Lys Lys Asn Lys Pro Lys Glu Pro Pro Lys Val Pro
    770                 775                 780                 
Lys Ser Ala Pro Phe Phe Ile Pro Thr Ile Pro Gly Leu Val Pro Arg
785                 790                 795                 800 
Tyr Ala Ala Pro Glu Gln Asn Asn Asp Pro Gln Gln Ser Lys Val Val
                805                 810                 815     
Asn Leu Gly Val Leu Ala Gln Lys Ser Asp Phe Cys Leu Lys Leu Glu
            820                 825                 830         
Glu Gly Leu Val Asn Asn Lys Tyr Asp Thr Ala Leu Asn Leu Leu Lys
        835                 840                 845             
Glu Ser Gly Pro Ser Gly Ile Glu Thr Glu Leu Arg Ser Leu Ser Pro
    850                 855                 860                 
Asp Cys Gly Gly Ser Ile Glu Val Met Gln Ser Phe Leu Lys Met Ile
865                 870                 875                 880 
Gly Met Met Leu Asp Arg Lys Arg Asp Phe Glu Leu Ala Gln Ala Tyr
                885                 890                 895     
Leu Ala Leu Phe Leu Lys Leu His Leu Lys Met Leu Pro Ser Glu Pro
            900                 905                 910         
Val Leu Leu Glu Glu Ile Thr Asn Leu Ser Ser Gln Val Glu Glu Asn
        915                 920                 925             
Trp Thr His Leu Gln Ser Leu Phe Asn Gln Ser Met Cys Ile Leu Asn
    930                 935                 940                 
Tyr Leu Lys Ser Ala Leu Leu
945                 950     


<210> 8337
<211> 156
<212> PRT
<213> Homo sapiens

<400> 8337
Met Thr Leu Pro Phe Val Gly Thr Ala Asp Glu Gln Arg Ala Tyr Asn
 1               5                  10                  15      
Pro Gly Arg Thr Gly Pro Ala Ala Leu Arg Pro Leu Val Lys Leu Lys
            20                  25                  30          
Ile Val Lys Lys Arg Thr Lys Lys Phe Ile Leu Tyr Gln Ser Asp Trp
        35                  40                  45              
Tyr Val Lys Ile Lys Pro Asn Trp Gln Lys Pro Arg Gly Ile Asp Asn
    50                  55                  60                  
Arg Val Cys Arg Arg Phe Lys Gly Gln Ile Leu Lys Pro Ile Val Gly
65                  70                  75                  80  
Tyr Gly Ser Asn Lys Lys Thr Lys His Met Leu Pro Asn Gly Phe Arg
                85                  90                  95      
Lys Phe Leu Val His Asp Ile Asn Glu Leu Glu Val Leu Met Met Cys
            100                 105                 110         
Asn Lys Ser Tyr Cys Ala Lys Ile Ala His Asn Val Ser Ser Lys Asn
        115                 120                 125             
Cys Lys Ala Ile Val Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Asn
    130                 135                 140                 
Asn Leu Asn Ala Ile Leu Arg Ser Lys Glu Asn Glu
145                 150                 155     


<210> 8338
<211> 2320
<212> PRT
<213> Homo sapiens

<400> 8338
Met Ala Glu Pro Ser Ser Ala Arg Arg Pro Val Pro Leu Ile Glu Ser
 1               5                  10                  15      
Glu Leu Tyr Phe Leu Ile Ala Arg Tyr Leu Ser Ala Gly Pro Cys Arg
            20                  25                  30          
Arg Ala Ala Gln Val Leu Val Gln Glu Leu Glu Gln Tyr Gln Leu Leu
        35                  40                  45              
Pro Lys Arg Leu Asp Trp Glu Gly Asn Glu His Asn Arg Ser Tyr Glu
    50                  55                  60                  
Glu Leu Val Leu Ser Asn Lys His Val Ala Pro Asp His Leu Leu Gln
65                  70                  75                  80  
Ile Cys Gln Arg Ile Gly Pro Met Leu Asp Lys Glu Ile Pro Pro Ser
                85                  90                  95      
Ile Ser Arg Val Thr Ser Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu
            100                 105                 110         
Arg Thr Ala Lys Asp Cys Arg His Thr Val Trp Lys Gly Ser Ala Phe
        115                 120                 125             
Ala Ala Leu His Arg Gly Arg Pro Pro Glu Met Pro Val Asn Tyr Gly
    130                 135                 140                 
Ser Pro Pro Asn Leu Val Glu Ile His Arg Gly Lys Gln Leu Thr Gly
145                 150                 155                 160 
Cys Ser Thr Phe Ser Thr Ala Phe Pro Gly Thr Met Tyr Gln His Ile
                165                 170                 175     
Lys Met His Arg Arg Ile Leu Gly His Leu Ser Ala Val Tyr Cys Val
            180                 185                 190         
Ala Phe Asp Arg Thr Gly His Arg Ile Phe Thr Gly Ser Asp Asp Cys
        195                 200                 205             
Leu Val Lys Ile Trp Ser Thr His Asn Gly Arg Leu Leu Ser Thr Leu
    210                 215                 220                 
Arg Gly His Ser Ala Glu Ile Ser Asp Met Ala Val Asn Tyr Glu Asn
225                 230                 235                 240 
Thr Met Ile Ala Ala Gly Ser Cys Asp Lys Ile Ile Arg Val Trp Cys
                245                 250                 255     
Leu Arg Thr Cys Ala Pro Val Ala Val Leu Gln Gly His Thr Gly Ser
            260                 265                 270         
Ile Thr Ser Leu Gln Phe Ser Pro Met Ala Lys Gly Ser Gln Arg Tyr
        275                 280                 285             
Met Val Ser Thr Gly Ala Asp Gly Thr Val Cys Phe Trp Gln Trp Asp
    290                 295                 300                 
Leu Glu Ser Leu Lys Phe Ser Pro Arg Pro Leu Lys Phe Thr Glu Lys
305                 310                 315                 320 
Pro Arg Pro Gly Val Gln Met Leu Cys Ser Ser Phe Ser Val Gly Gly
                325                 330                 335     
Met Phe Leu Ala Thr Gly Ser Thr Asp His Val Ile Arg Met Tyr Phe
            340                 345                 350         
Leu Gly Phe Glu Ala Pro Glu Lys Ile Ala Glu Leu Glu Ser His Thr
        355                 360                 365             
Asp Lys Val Asp Ser Ile Gln Phe Cys Asn Asn Gly Asp Arg Phe Leu
    370                 375                 380                 
Ser Gly Ser Arg Asp Gly Thr Ala Arg Ile Trp Arg Phe Glu Gln Leu
385                 390                 395                 400 
Glu Trp Arg Ser Ile Leu Leu Asp Met Ala Thr Arg Ile Ser Gly Asp
                405                 410                 415     
Leu Ser Ser Glu Glu Glu Arg Phe Met Lys Pro Lys Val Thr Met Ile
            420                 425                 430         
Ala Trp Asn Gln Asn Asp Ser Ile Val Val Thr Ala Val Asn Asp His
        435                 440                 445             
Val Leu Lys Val Trp Asn Ser Tyr Thr Gly Gln Leu Leu His Asn Leu
    450                 455                 460                 
Met Gly His Ala Asp Glu Val Phe Val Leu Glu Thr His Pro Phe Asp
465                 470                 475                 480 
Ser Arg Ile Met Leu Ser Ala Gly His Asp Gly Ser Ile Phe Ile Trp
                485                 490                 495     
Asp Ile Thr Lys Gly Thr Lys Met Lys His Tyr Phe Asn Met Ile Glu
            500                 505                 510         
Gly Gln Gly His Gly Ala Val Phe Asp Cys Lys Phe Ser Gln Asp Gly
        515                 520                 525             
Gln His Phe Ala Cys Thr Asp Ser His Gly His Leu Leu Ile Phe Gly
    530                 535                 540                 
Phe Gly Cys Ser Lys Pro Tyr Glu Lys Ile Pro Asp Gln Met Phe Phe
545                 550                 555                 560 
His Thr Asp Tyr Arg Pro Leu Ile Arg Asp Ser Asn Asn Tyr Val Leu
                565                 570                 575     
Asp Glu Gln Thr Gln Gln Ala Pro His Leu Met Pro Pro Pro Phe Leu
            580                 585                 590         
Val Asp Val Asp Gly Asn Pro His Pro Thr Lys Tyr Gln Arg Leu Val
        595                 600                 605             
Pro Gly Arg Glu Asn Ser Ala Asp Glu His Leu Ile Pro Gln Leu Gly
    610                 615                 620                 
Tyr Val Ala Thr Ser Asp Gly Glu Val Ile Glu Gln Ile Ile Ser Leu
625                 630                 635                 640 
Gln Thr Asn Asp Asn Asp Glu Arg Ser Pro Glu Ser Ser Ile Leu Asp
                645                 650                 655     
Gly Met Ile Arg Gln Leu Gln Gln Gln Gln Asp Gln Arg Met Gly Ala
            660                 665                 670         
Asp Gln Asp Thr Ile Pro Arg Gly Leu Ser Asn Gly Glu Glu Thr Pro
        675                 680                 685             
Arg Arg Gly Phe Arg Arg Leu Ser Leu Asp Ile Gln Ser Pro Pro Asn
    690                 695                 700                 
Ile Gly Leu Arg Arg Ser Gly Gln Val Glu Gly Val Arg Gln Met His
705                 710                 715                 720 
Gln Asn Ala Pro Arg Ser Gln Ile Ala Thr Glu Arg Asp Leu Gln Ala
                725                 730                 735     
Trp Lys Arg Arg Val Val Val Pro Glu Val Pro Leu Gly Ile Phe Arg
            740                 745                 750         
Lys Leu Glu Asp Phe Arg Leu Glu Lys Gly Glu Glu Glu Arg Asn Leu
        755                 760                 765             
Tyr Ile Ile Gly Arg Lys Arg Lys Thr Leu Gln Leu Ser His Lys Ser
    770                 775                 780                 
Asp Ser Val Val Leu Val Ser Gln Ser Arg Gln Arg Thr Cys Arg Arg
785                 790                 795                 800 
Lys Tyr Pro Asn Tyr Gly Arg Arg Asn Arg Ser Trp Arg Glu Leu Ser
                805                 810                 815     
Ser Gly Asn Glu Ser Ser Ser Ser Val Arg His Glu Thr Ser Cys Asp
            820                 825                 830         
Gln Ser Glu Gly Ser Gly Ser Ser Glu Glu Asp Glu Trp Arg Ser Asp
        835                 840                 845             
Arg Lys Ser Glu Ser Tyr Ser Glu Ser Ser Ser Asp Ser Ser Ser Arg
    850                 855                 860                 
Tyr Ser Asp Trp Thr Ala Asp Ala Gly Ile Asn Leu Gln Pro Pro Leu
865                 870                 875                 880 
Arg Thr Ser Cys Arg Arg Arg Ile Thr Arg Phe Cys Ser Ser Ser Glu
                885                 890                 895     
Asp Glu Ile Ser Thr Glu Asn Leu Ser Pro Pro Lys Arg Arg Arg Lys
            900                 905                 910         
Arg Lys Lys Glu Asn Lys Pro Lys Lys Glu Asn Leu Arg Arg Met Thr
        915                 920                 925             
Pro Ala Glu Leu Ala Asn Met Glu His Leu Tyr Glu Phe His Pro Pro
    930                 935                 940                 
Val Trp Ile Thr Asp Thr Thr Leu Arg Lys Ser Pro Phe Val Pro Gln
945                 950                 955                 960 
Met Gly Asp Glu Val Ile Tyr Phe Arg Gln Gly His Glu Ala Tyr Ile
                965                 970                 975     
Glu Ala Val Arg Arg Asn Asn Ile Tyr Glu Leu Asn Pro Asn Lys Glu
            980                 985                 990         
Pro Trp Arg Lys Met Asp Leu Arg Asp Gln Glu Leu Val Lys Ile Val
        995                 1000                1005            
Gly Ile Arg Tyr Glu Val Gly Pro Pro Thr Leu Cys Cys Leu Lys Leu
    1010                1015                1020                
Ala Phe Ile Asp Pro Ala Thr Gly Lys Leu Met Asp Lys Ser Phe Ser
1025                1030                1035                1040
Ile Arg Tyr His Asp Met Pro Asp Val Ile Asp Phe Leu Val Leu Arg
                1045                1050                1055    
Gln Phe Tyr Asp Glu Ala Arg Gln Arg Asn Trp Gln Ser Cys Asp Arg
            1060                1065                1070        
Phe Arg Ser Ile Ile Asp Asp Ala Trp Trp Phe Gly Thr Val Leu Ser
        1075                1080                1085            
Gln Glu Pro Tyr Gln Pro Gln Tyr Pro Asp Ser His Phe Gln Cys Tyr
    1090                1095                1100                
Ile Val Arg Trp Asp Asn Thr Glu Ile Glu Lys Leu Ser Pro Trp Asp
1105                1110                1115                1120
Met Glu Pro Ile Pro Asp Asn Val Asp Pro Pro Glu Glu Leu Gly Ala
                1125                1130                1135    
Ser Ile Ser Val Thr Thr Asp Glu Leu Glu Lys Leu Leu Tyr Lys Pro
            1140                1145                1150        
Gln Ala Gly Glu Trp Gly Gln Lys Ser Arg Asp Glu Glu Cys Asp Arg
        1155                1160                1165            
Ile Ile Ser Gly Ile Asp Gln Leu Leu Asn Leu Asp Ile Ala Ala Ala
    1170                1175                1180                
Phe Ala Gly Pro Val Asp Leu Cys Thr Tyr Pro Lys Tyr Cys Thr Val
1185                1190                1195                1200
Val Ala Tyr Pro Thr Asp Leu Tyr Thr Ile Arg Met Arg Leu Val Asn
                1205                1210                1215    
Arg Phe Tyr Arg Arg Leu Ser Ala Leu Val Trp Glu Val Arg Tyr Ile
            1220                1225                1230        
Glu His Asn Ala Arg Thr Phe Asn Glu Pro Glu Ser Val Ile Ala Arg
        1235                1240                1245            
Ser Ala Lys Lys Ile Thr Asp Gln Leu Leu Lys Phe Ile Lys Asn Gln
    1250                1255                1260                
His Cys Thr Asn Ile Ser Glu Leu Ser Asn Thr Ser Glu Asn Asp Glu
1265                1270                1275                1280
Gln Asn Ala Glu Asp Leu Asp Asp Ser Asp Leu Pro Lys Thr Ser Ser
                1285                1290                1295    
Gly Arg Arg Arg Val His Asp Gly Lys Lys Ser Ile Arg Ala Thr Asn
            1300                1305                1310        
Tyr Val Glu Ser Asn Trp Lys Lys Gln Cys Lys Glu Leu Val Asn Leu
        1315                1320                1325            
Ile Phe Gln Cys Glu Asp Ser Glu Pro Phe Arg Gln Pro Val Asp Leu
    1330                1335                1340                
Val Glu Tyr Pro Asp Tyr Arg Asp Ile Ile Asp Thr Pro Met Asp Phe
1345                1350                1355                1360
Gly Thr Val Arg Glu Thr Leu Asp Ala Gly Asn Tyr Asp Ser Pro Leu
                1365                1370                1375    
Glu Phe Cys Lys Asp Ile Arg Leu Ile Phe Ser Asn Ala Lys Ala Tyr
            1380                1385                1390        
Thr Pro Asn Lys Arg Ser Lys Ile Tyr Ser Met Thr Leu Arg Leu Ser
        1395                1400                1405            
Ala Leu Phe Glu Glu Lys Met Lys Lys Ile Ser Ser Asp Phe Lys Ile
    1410                1415                1420                
Gly Gln Lys Phe Asn Glu Lys Leu Arg Arg Ser Gln Arg Phe Lys Gln
1425                1430                1435                1440
Arg Gln Asn Cys Lys Gly Asp Ser Gln Pro Asn Lys Ser Ile Arg Asn
                1445                1450                1455    
Leu Lys Pro Lys Arg Leu Lys Ser Gln Thr Lys Ile Ile Pro Glu Leu
            1460                1465                1470        
Val Gly Ser Pro Thr Gln Ser Thr Ser Ser Arg Thr Ala Tyr Leu Gly
        1475                1480                1485            
Thr His Lys Thr Ser Ala Gly Ile Ser Ser Gly Val Thr Ser Gly Asp
    1490                1495                1500                
Ser Ser Asp Ser Ala Glu Pro Ser Glu Arg Arg Lys Arg Asn Arg Pro
1505                1510                1515                1520
Ile Thr Asn Gly Ser Thr Leu Ser Glu Ser Glu Val Glu Asp Ser Leu
                1525                1530                1535    
Ala Thr Ser Leu Ser Ser Ser Ala Ser Ser Ser Ser Glu Glu Ser Lys
            1540                1545                1550        
Glu Ser Ser Arg Ala Arg Glu Ser Ser Ser Arg Ser Gly Leu Ser Arg
        1555                1560                1565            
Ser Ser Asn Leu Arg Val Thr Arg Thr Arg Ala Ala Gln Arg Lys Thr
    1570                1575                1580                
Gly Pro Val Ser Leu Ala Asn Gly Cys Gly Arg Lys Ala Thr Arg Lys
1585                1590                1595                1600
Arg Val Tyr Leu Ser Asp Ser Asp Asn Asn Ser Leu Glu Thr Gly Glu
                1605                1610                1615    
Ile Leu Lys Ala Arg Ala Gly Asn Asn Arg Lys Val Leu Arg Lys Cys
            1620                1625                1630        
Ala Ala Val Ala Ala Asn Lys Ile Lys Leu Met Ser Asp Val Glu Glu
        1635                1640                1645            
Asn Ser Ser Ser Glu Ser Val Cys Ser Gly Arg Lys Leu Pro His Arg
    1650                1655                1660                
Asn Ala Ser Ala Val Ala Arg Lys Lys Leu Leu His Asn Ser Glu Asp
1665                1670                1675                1680
Glu Gln Ser Leu Lys Ser Glu Ile Glu Glu Glu Glu Leu Lys Asp Glu
                1685                1690                1695    
Asn Gln Pro Leu Pro Val Ser Ser Ser His Thr Ala Gln Ser Asn Val
            1700                1705                1710        
Asp Glu Ser Glu Asn Arg Asp Ser Glu Ser Glu Ser Asp Leu Arg Val
        1715                1720                1725            
Ala Arg Lys Asn Trp His Ala Asn Gly Tyr Lys Ser His Thr Pro Ala
    1730                1735                1740                
Pro Ser Lys Thr Lys Phe Leu Lys Ile Glu Ser Ser Glu Glu Asp Ser
1745                1750                1755                1760
Lys Ser His Asp Ser Asp His Ala Cys Asn Arg Thr Ala Gly Pro Ser
                1765                1770                1775    
Thr Ser Val Gln Lys Leu Lys Ala Glu Ser Ile Ser Glu Glu Ala Asp
            1780                1785                1790        
Ser Glu Pro Gly Arg Ser Gly Gly Arg Lys Tyr Asn Thr Phe His Lys
        1795                1800                1805            
Asn Ala Ser Phe Phe Lys Lys Thr Lys Ile Leu Ser Asp Ser Glu Asp
    1810                1815                1820                
Ser Glu Ser Glu Glu Gln Asp Arg Glu Asp Gly Lys Cys His Lys Met
1825                1830                1835                1840
Glu Met Asn Pro Ile Ser Gly Asn Leu Asn Cys Asp Pro Ile Ala Met
                1845                1850                1855    
Ser Gln Cys Ser Ser Asp His Gly Cys Glu Thr Asp Leu Asp Ser Asp
            1860                1865                1870        
Asp Asp Lys Ile Glu Lys Pro Asn Asn Phe Met Lys Asp Ser Ala Ser
        1875                1880                1885            
Gln Asp Asn Gly Leu Ser Arg Lys Ile Ser Arg Lys Arg Val Cys Ser
    1890                1895                1900                
Ser Asp Ser Asp Ser Ser Leu Gln Val Val Lys Lys Ser Ser Lys Ala
1905                1910                1915                1920
Arg Thr Gly Leu Leu Arg Ile Thr Arg Arg Cys Ala Ala Thr Ala Ala
                1925                1930                1935    
Asn Lys Ile Lys Leu Met Ser Asp Val Glu Asp Val Ser Leu Glu Asn
            1940                1945                1950        
Val His Thr Arg Ser Lys Asn Gly Arg Lys Lys Pro Leu His Leu Ala
        1955                1960                1965            
Cys Thr Thr Ala Lys Lys Lys Leu Ser Asp Cys Glu Gly Ser Val His
    1970                1975                1980                
Cys Glu Val Pro Ser Glu Gln Tyr Ala Cys Glu Gly Lys Pro Pro Asp
1985                1990                1995                2000
Pro Asp Ser Glu Gly Ser Thr Lys Val Leu Ser Gln Ala Leu Asn Gly
                2005                2010                2015    
Asp Ser Asp Ser Glu Asp Met Leu Asn Ser Glu His Lys His Arg His
            2020                2025                2030        
Thr Asn Ile His Lys Ile Asp Ala Pro Ser Lys Arg Lys Ser Ser Ser
        2035                2040                2045            
Val Thr Ser Ser Gly Glu Asp Ser Lys Ser His Ile Pro Gly Ser Glu
    2050                2055                2060                
Thr Asp Arg Thr Phe Ser Ser Glu Ser Thr Leu Ala Gln Lys Ala Thr
2065                2070                2075                2080
Ala Glu Asn Asn Phe Glu Val Glu Leu Asn Tyr Gly Leu Arg Arg Trp
                2085                2090                2095    
Asn Gly Arg Arg Leu Arg Thr Tyr Gly Lys Ala Pro Phe Ser Lys Thr
            2100                2105                2110        
Lys Val Ile His Asp Ser Gln Glu Thr Ala Glu Lys Glu Val Lys Arg
        2115                2120                2125            
Lys Arg Ser His Pro Glu Leu Glu Asn Val Lys Ile Ser Glu Thr Thr
    2130                2135                2140                
Gly Asn Ser Lys Phe Arg Pro Asp Thr Ser Ser Lys Ser Ser Asp Leu
2145                2150                2155                2160
Gly Ser Val Thr Glu Ser Asp Ile Asp Cys Thr Asp Asn Thr Lys Thr
                2165                2170                2175    
Lys Arg Arg Lys Thr Lys Gly Lys Ala Lys Val Val Arg Lys Glu Phe
            2180                2185                2190        
Val Pro Arg Asp Arg Glu Pro Asn Thr Lys Val Arg Thr Cys Met His
        2195                2200                2205            
Asn Gln Lys Asp Ala Val Gln Met Pro Ser Glu Thr Leu Lys Ala Lys
    2210                2215                2220                
Met Val Pro Glu Lys Val Pro Arg Arg Cys Ala Thr Val Ala Ala Asn
2225                2230                2235                2240
Lys Ile Lys Ile Met Ser Asn Leu Lys Glu Thr Ile Ser Gly Pro Glu
                2245                2250                2255    
Asn Val Trp Ile Arg Lys Ser Ser Arg Lys Leu Pro His Arg Asn Ala
            2260                2265                2270        
Ser Ala Ala Ala Lys Lys Lys Leu Leu Asn Val Tyr Lys Glu Asp Asp
        2275                2280                2285            
Thr Thr Ile Asn Ser Glu Ser Glu Lys Glu Leu Glu Asp Ile Asn Arg
    2290                2295                2300                
Lys Met Leu Phe Leu Arg Gly Phe Arg Ser Trp Lys Glu Asn Ala Gln
2305                2310                2315                2320


<210> 8339
<211> 2269
<212> PRT
<213> Homo sapiens

<400> 8339
Met Ala Glu Pro Ser Ser Ala Arg Arg Pro Val Pro Leu Ile Glu Ser
 1               5                  10                  15      
Glu Leu Tyr Phe Leu Ile Ala Arg Tyr Leu Ser Ala Gly Pro Cys Arg
            20                  25                  30          
Arg Ala Ala Gln Val Leu Val Gln Glu Leu Glu Gln Tyr Gln Leu Leu
        35                  40                  45              
Pro Lys Arg Leu Asp Trp Glu Gly Asn Glu His Asn Arg Ser Tyr Glu
    50                  55                  60                  
Glu Leu Val Leu Ser Asn Lys His Val Ala Pro Asp His Leu Leu Gln
65                  70                  75                  80  
Ile Cys Gln Arg Ile Gly Pro Met Leu Asp Lys Glu Ile Pro Pro Ser
                85                  90                  95      
Ile Ser Arg Val Thr Ser Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu
            100                 105                 110         
Arg Thr Ala Lys Asp Cys Arg His Thr Val Trp Lys Gly Ser Ala Phe
        115                 120                 125             
Ala Ala Leu His Arg Gly Arg Pro Pro Glu Met Pro Val Asn Tyr Gly
    130                 135                 140                 
Ser Pro Pro Asn Leu Val Glu Ile His Arg Gly Lys Gln Leu Thr Gly
145                 150                 155                 160 
Cys Ser Thr Phe Ser Thr Ala Phe Pro Gly Thr Met Tyr Gln His Ile
                165                 170                 175     
Lys Met His Arg Arg Ile Leu Gly His Leu Ser Ala Val Tyr Cys Val
            180                 185                 190         
Ala Phe Asp Arg Thr Gly His Arg Ile Phe Thr Gly Ser Asp Asp Cys
        195                 200                 205             
Leu Val Lys Ile Trp Ser Thr His Asn Gly Arg Leu Leu Ser Thr Leu
    210                 215                 220                 
Arg Gly His Ser Ala Glu Ile Ser Asp Met Ala Val Asn Tyr Glu Asn
225                 230                 235                 240 
Thr Met Ile Ala Ala Gly Ser Cys Asp Lys Ile Ile Arg Val Trp Cys
                245                 250                 255     
Leu Arg Thr Cys Ala Pro Val Ala Val Leu Gln Gly His Thr Gly Ser
            260                 265                 270         
Ile Thr Ser Leu Gln Phe Ser Pro Met Ala Lys Gly Ser Gln Arg Tyr
        275                 280                 285             
Met Val Ser Thr Gly Ala Asp Gly Thr Val Cys Phe Trp Gln Trp Asp
    290                 295                 300                 
Leu Glu Ser Leu Lys Phe Ser Pro Arg Pro Leu Lys Phe Thr Glu Lys
305                 310                 315                 320 
Pro Arg Pro Gly Val Gln Met Leu Cys Ser Ser Phe Ser Val Gly Gly
                325                 330                 335     
Met Phe Leu Ala Thr Gly Ser Thr Asp His Val Ile Arg Met Tyr Phe
            340                 345                 350         
Leu Gly Phe Glu Ala Pro Glu Lys Ile Ala Glu Leu Glu Ser His Thr
        355                 360                 365             
Asp Lys Val Asp Ser Ile Gln Phe Cys Asn Asn Gly Asp Arg Phe Leu
    370                 375                 380                 
Ser Gly Ser Arg Asp Gly Thr Ala Arg Ile Trp Arg Phe Glu Gln Leu
385                 390                 395                 400 
Glu Trp Arg Ser Ile Leu Leu Asp Met Ala Thr Arg Ile Ser Gly Asp
                405                 410                 415     
Leu Ser Ser Glu Glu Glu Arg Phe Met Lys Pro Lys Val Thr Met Ile
            420                 425                 430         
Ala Trp Asn Gln Asn Asp Ser Ile Val Val Thr Ala Val Asn Asp His
        435                 440                 445             
Val Leu Lys Val Trp Asn Ser Tyr Thr Gly Gln Leu Leu His Asn Leu
    450                 455                 460                 
Met Gly His Ala Asp Glu Val Phe Val Leu Glu Thr His Pro Phe Asp
465                 470                 475                 480 
Ser Arg Ile Met Leu Ser Ala Gly His Asp Gly Ser Ile Phe Ile Trp
                485                 490                 495     
Asp Ile Thr Lys Gly Thr Lys Met Lys His Tyr Phe Asn Met Ile Glu
            500                 505                 510         
Gly Gln Gly His Gly Ala Val Phe Asp Cys Lys Phe Ser Gln Asp Gly
        515                 520                 525             
Gln His Phe Ala Cys Thr Asp Ser His Gly His Leu Leu Ile Phe Gly
    530                 535                 540                 
Phe Gly Cys Ser Lys Pro Tyr Glu Lys Ile Pro Asp Gln Met Phe Phe
545                 550                 555                 560 
His Thr Asp Tyr Arg Pro Leu Ile Arg Asp Ser Asn Asn Tyr Val Leu
                565                 570                 575     
Asp Glu Gln Thr Gln Gln Ala Pro His Leu Met Pro Pro Pro Phe Leu
            580                 585                 590         
Val Asp Val Asp Gly Asn Pro His Pro Thr Lys Tyr Gln Arg Leu Val
        595                 600                 605             
Pro Gly Arg Glu Asn Ser Ala Asp Glu His Leu Ile Pro Gln Leu Gly
    610                 615                 620                 
Tyr Val Ala Thr Ser Asp Gly Glu Val Ile Glu Gln Ile Ile Ser Leu
625                 630                 635                 640 
Gln Thr Asn Asp Asn Asp Glu Arg Ser Pro Glu Ser Ser Ile Leu Asp
                645                 650                 655     
Gly Met Ile Arg Gln Leu Gln Gln Gln Gln Asp Gln Arg Met Gly Ala
            660                 665                 670         
Asp Gln Asp Thr Ile Pro Arg Gly Leu Ser Asn Gly Glu Glu Thr Pro
        675                 680                 685             
Arg Arg Gly Phe Arg Arg Leu Ser Leu Asp Ile Gln Ser Pro Pro Asn
    690                 695                 700                 
Ile Gly Leu Arg Arg Ser Gly Gln Val Glu Gly Val Arg Gln Met His
705                 710                 715                 720 
Gln Asn Ala Pro Arg Ser Gln Ile Ala Thr Glu Arg Asp Leu Gln Ala
                725                 730                 735     
Trp Lys Arg Arg Val Val Val Pro Glu Val Pro Leu Gly Ile Phe Arg
            740                 745                 750         
Lys Leu Glu Asp Phe Arg Leu Glu Lys Gly Glu Glu Glu Arg Asn Leu
        755                 760                 765             
Tyr Ile Ile Gly Arg Lys Arg Lys Thr Leu Gln Leu Ser His Lys Ser
    770                 775                 780                 
Asp Ser Val Val Leu Val Ser Gln Ser Arg Gln Arg Thr Cys Arg Arg
785                 790                 795                 800 
Lys Tyr Pro Asn Tyr Gly Arg Arg Asn Arg Ser Trp Arg Glu Leu Ser
                805                 810                 815     
Ser Gly Asn Glu Ser Ser Ser Ser Val Arg His Glu Thr Ser Cys Asp
            820                 825                 830         
Gln Ser Glu Gly Ser Gly Ser Ser Glu Glu Asp Glu Trp Arg Ser Asp
        835                 840                 845             
Arg Lys Ser Glu Ser Tyr Ser Glu Ser Ser Ser Asp Ser Ser Ser Arg
    850                 855                 860                 
Tyr Ser Asp Trp Thr Ala Asp Ala Gly Ile Asn Leu Gln Pro Pro Leu
865                 870                 875                 880 
Arg Thr Ser Cys Arg Arg Arg Ile Thr Arg Phe Cys Ser Ser Ser Glu
                885                 890                 895     
Asp Glu Ile Ser Thr Glu Asn Leu Ser Pro Pro Lys Arg Arg Arg Lys
            900                 905                 910         
Arg Lys Lys Glu Asn Lys Pro Lys Lys Glu Asn Leu Arg Arg Met Thr
        915                 920                 925             
Pro Ala Glu Leu Ala Asn Met Glu His Leu Tyr Glu Phe His Pro Pro
    930                 935                 940                 
Val Trp Ile Thr Asp Thr Thr Leu Arg Lys Ser Pro Phe Val Pro Gln
945                 950                 955                 960 
Met Gly Asp Glu Val Ile Tyr Phe Arg Gln Gly His Glu Ala Tyr Ile
                965                 970                 975     
Glu Ala Val Arg Arg Asn Asn Ile Tyr Glu Leu Asn Pro Asn Lys Glu
            980                 985                 990         
Pro Trp Arg Lys Met Asp Leu Arg Asp Gln Glu Leu Val Lys Ile Val
        995                 1000                1005            
Gly Ile Arg Tyr Glu Val Gly Pro Pro Thr Leu Cys Cys Leu Lys Leu
    1010                1015                1020                
Ala Phe Ile Asp Pro Ala Thr Gly Lys Leu Met Asp Lys Ser Phe Ser
1025                1030                1035                1040
Ile Arg Tyr His Asp Met Pro Asp Val Ile Asp Phe Leu Val Leu Arg
                1045                1050                1055    
Gln Phe Tyr Asp Glu Ala Arg Gln Arg Asn Trp Gln Ser Cys Asp Arg
            1060                1065                1070        
Phe Arg Ser Ile Ile Asp Asp Ala Trp Trp Phe Gly Thr Val Leu Ser
        1075                1080                1085            
Gln Glu Pro Tyr Gln Pro Gln Tyr Pro Asp Ser His Phe Gln Cys Tyr
    1090                1095                1100                
Ile Val Arg Trp Asp Asn Thr Glu Ile Glu Lys Leu Ser Pro Trp Asp
1105                1110                1115                1120
Met Glu Pro Ile Pro Asp Asn Val Asp Pro Pro Glu Glu Leu Gly Ala
                1125                1130                1135    
Ser Ile Ser Val Thr Thr Asp Glu Leu Glu Lys Leu Leu Tyr Lys Pro
            1140                1145                1150        
Gln Ala Gly Glu Trp Gly Gln Lys Ser Arg Asp Glu Glu Cys Asp Arg
        1155                1160                1165            
Ile Ile Ser Gly Ile Asp Gln Leu Leu Asn Leu Asp Ile Ala Ala Ala
    1170                1175                1180                
Phe Ala Gly Pro Val Asp Leu Cys Thr Tyr Pro Lys Tyr Cys Thr Val
1185                1190                1195                1200
Val Ala Tyr Pro Thr Asp Leu Tyr Thr Ile Arg Met Arg Leu Val Asn
                1205                1210                1215    
Arg Phe Tyr Arg Arg Leu Ser Ala Leu Val Trp Glu Val Arg Tyr Ile
            1220                1225                1230        
Glu His Asn Ala Arg Thr Phe Asn Glu Pro Glu Ser Val Ile Ala Arg
        1235                1240                1245            
Ser Ala Lys Lys Ile Thr Asp Gln Leu Leu Lys Phe Ile Lys Asn Gln
    1250                1255                1260                
His Cys Thr Asn Ile Ser Glu Leu Ser Asn Thr Ser Glu Asn Asp Glu
1265                1270                1275                1280
Gln Asn Ala Glu Asp Leu Asp Asp Ser Asp Leu Pro Lys Thr Ser Ser
                1285                1290                1295    
Gly Arg Arg Arg Val His Asp Gly Lys Lys Ser Ile Arg Ala Thr Asn
            1300                1305                1310        
Tyr Val Glu Ser Asn Trp Lys Lys Gln Cys Lys Glu Leu Val Asn Leu
        1315                1320                1325            
Ile Phe Gln Cys Glu Asp Ser Glu Pro Phe Arg Gln Pro Val Asp Leu
    1330                1335                1340                
Val Glu Tyr Pro Asp Tyr Arg Asp Ile Ile Asp Thr Pro Met Asp Phe
1345                1350                1355                1360
Gly Thr Val Arg Glu Thr Leu Asp Ala Gly Asn Tyr Asp Ser Pro Leu
                1365                1370                1375    
Glu Phe Cys Lys Asp Ile Arg Leu Ile Phe Ser Asn Ala Lys Ala Tyr
            1380                1385                1390        
Thr Pro Asn Lys Arg Ser Lys Ile Tyr Ser Met Thr Leu Arg Leu Ser
        1395                1400                1405            
Ala Leu Phe Glu Glu Lys Met Lys Lys Ile Ser Ser Asp Phe Lys Ile
    1410                1415                1420                
Gly Gln Lys Phe Asn Glu Lys Leu Arg Arg Ser Gln Arg Phe Lys Gln
1425                1430                1435                1440
Arg Gln Asn Cys Lys Gly Asp Ser Gln Pro Asn Lys Ser Ile Arg Asn
                1445                1450                1455    
Leu Lys Pro Lys Arg Leu Lys Ser Gln Thr Lys Ile Ile Pro Glu Leu
            1460                1465                1470        
Val Gly Ser Pro Thr Gln Ser Thr Ser Ser Arg Thr Ala Tyr Leu Gly
        1475                1480                1485            
Thr His Lys Thr Ser Ala Gly Ile Ser Ser Gly Val Thr Ser Gly Asp
    1490                1495                1500                
Ser Ser Asp Ser Ala Glu Ser Ser Glu Arg Arg Lys Arg Asn Arg Pro
1505                1510                1515                1520
Ile Thr Asn Gly Ser Thr Leu Ser Glu Ser Glu Val Glu Asp Ser Leu
                1525                1530                1535    
Ala Thr Ser Leu Ser Ser Ser Ala Ser Ser Ser Ser Glu Glu Ser Lys
            1540                1545                1550        
Glu Ser Ser Arg Ala Arg Glu Ser Ser Ser Arg Ser Gly Leu Ser Arg
        1555                1560                1565            
Ser Ser Asn Leu Arg Val Thr Arg Thr Arg Ala Ala Gln Arg Lys Thr
    1570                1575                1580                
Gly Pro Val Ser Leu Ala Asn Gly Cys Gly Arg Lys Ala Thr Arg Lys
1585                1590                1595                1600
Arg Val Tyr Leu Ser Asp Ser Asp Asn Asn Ser Leu Glu Thr Gly Glu
                1605                1610                1615    
Ile Leu Lys Ala Arg Ala Gly Asn Asn Arg Lys Val Leu Arg Lys Cys
            1620                1625                1630        
Ala Ala Val Ala Ala Asn Lys Ile Lys Leu Met Ser Asp Val Glu Glu
        1635                1640                1645            
Asn Ser Ser Ser Glu Ser Val Cys Ser Gly Arg Lys Leu Pro His Arg
    1650                1655                1660                
Asn Ala Ser Ala Val Ala Arg Lys Lys Leu Leu His Asn Ser Glu Asp
1665                1670                1675                1680
Glu Gln Ser Leu Lys Ser Glu Ile Glu Glu Glu Glu Leu Lys Asp Glu
                1685                1690                1695    
Asn Gln Pro Leu Pro Val Ser Ser Ser His Thr Ala Gln Ser Asn Val
            1700                1705                1710        
Asp Glu Ser Glu Asn Arg Asp Ser Glu Ser Glu Ser Asp Leu Arg Val
        1715                1720                1725            
Ala Arg Lys Asn Trp His Ala Asn Gly Tyr Lys Ser His Thr Pro Ala
    1730                1735                1740                
Pro Ser Lys Thr Lys Phe Leu Lys Ile Glu Ser Ser Glu Glu Asp Ser
1745                1750                1755                1760
Lys Ser His Asp Ser Asp His Ala Cys Asn Arg Thr Ala Gly Pro Ser
                1765                1770                1775    
Thr Ser Val Gln Lys Leu Lys Ala Glu Ser Ile Ser Glu Glu Ala Asp
            1780                1785                1790        
Ser Glu Pro Gly Arg Ser Gly Gly Arg Lys Tyr Asn Thr Phe His Lys
        1795                1800                1805            
Asn Ala Ser Phe Phe Lys Lys Thr Lys Ile Leu Ser Asp Ser Glu Asp
    1810                1815                1820                
Ser Glu Ser Glu Glu Gln Asp Arg Glu Asp Gly Lys Cys His Lys Met
1825                1830                1835                1840
Glu Met Asn Pro Ile Ser Gly Asn Leu Asn Cys Asp Pro Ile Ala Met
                1845                1850                1855    
Ser Gln Cys Ser Ser Asp His Gly Cys Glu Thr Asp Leu Asp Ser Asp
            1860                1865                1870        
Asp Asp Lys Ile Glu Lys Pro Asn Asn Phe Met Lys Asp Ser Ala Ser
        1875                1880                1885            
Gln Asp Asn Gly Leu Ser Arg Lys Ile Ser Arg Lys Arg Val Cys Ser
    1890                1895                1900                
Ser Asp Ser Asp Ser Ser Leu Gln Val Val Lys Lys Ser Ser Lys Ala
1905                1910                1915                1920
Arg Thr Gly Leu Leu Arg Ile Thr Arg Arg Cys Ala Ala Thr Ala Ala
                1925                1930                1935    
Asn Lys Ile Lys Leu Met Ser Asp Val Glu Asp Val Ser Leu Glu Asn
            1940                1945                1950        
Val His Thr Arg Ser Lys Asn Gly Arg Lys Lys Pro Leu His Leu Ala
        1955                1960                1965            
Cys Thr Thr Ala Lys Lys Lys Leu Ser Asp Cys Glu Gly Ser Val His
    1970                1975                1980                
Cys Glu Val Pro Ser Glu Gln Tyr Ala Cys Glu Gly Lys Pro Pro Asp
1985                1990                1995                2000
Pro Asp Ser Glu Gly Ser Thr Lys Val Leu Ser Gln Ala Leu Asn Gly
                2005                2010                2015    
Asp Ser Asp Ser Glu Asp Met Leu Asn Ser Glu His Lys His Arg His
            2020                2025                2030        
Thr Asn Ile His Lys Ile Asp Ala Pro Ser Lys Arg Lys Ser Ser Ser
        2035                2040                2045            
Val Thr Ser Ser Gly Glu Asp Ser Lys Ser His Ile Pro Gly Ser Glu
    2050                2055                2060                
Thr Asp Arg Thr Phe Ser Ser Glu Ser Thr Leu Ala Gln Lys Ala Thr
2065                2070                2075                2080
Ala Glu Asn Asn Phe Glu Val Glu Leu Asn Tyr Gly Leu Arg Arg Trp
                2085                2090                2095    
Asn Gly Arg Arg Leu Arg Thr Tyr Gly Lys Ala Pro Phe Ser Lys Thr
            2100                2105                2110        
Lys Val Ile His Asp Ser Gln Glu Thr Ala Glu Lys Glu Val Lys Arg
        2115                2120                2125            
Lys Arg Ser His Pro Glu Leu Glu Asn Val Lys Ile Ser Glu Thr Thr
    2130                2135                2140                
Gly Asn Ser Lys Phe Arg Pro Asp Thr Ser Ser Lys Ser Ser Asp Leu
2145                2150                2155                2160
Gly Ser Val Thr Glu Ser Asp Ile Asp Cys Thr Asp Asn Thr Lys Thr
                2165                2170                2175    
Lys Arg Arg Lys Thr Lys Gly Lys Ala Lys Val Val Arg Lys Gly Lys
            2180                2185                2190        
Thr Phe Thr Ala Asn Ile Ser Lys Thr Val Arg Arg Gln Arg Gln Ser
        2195                2200                2205            
Lys Arg Pro Arg Leu Ser Val Asp Asp Asn Asp Trp Glu Asp Leu Asp
    2210                2215                2220                
Tyr Ala Lys Ser Lys Arg Val Leu Arg Arg Ser Lys Ile Lys Thr Arg
2225                2230                2235                2240
Asn Gln Gly Arg Arg Thr Val Arg Tyr His Asp Gly Asp Asp Asp Arg
                2245                2250                2255    
Ser Leu Glu Asn Val Leu Asp Phe Asn Gly Cys Thr Leu
            2260                2265                


<210> 8340
<211> 573
<212> PRT
<213> Homo sapiens

<400> 8340
Ser Trp Arg Thr Met Gly Ser Thr Leu Gly Cys His Arg Ser Ile Pro
 1               5                  10                  15      
Arg Asp Pro Ser Asp Leu Ser His Ser Arg Lys Phe Ser Ala Ala Cys
            20                  25                  30          
Asn Phe Ser Asn Ile Leu Val Asn Gln Glu Arg Leu Asn Ile Asn Thr
        35                  40                  45              
Ala Thr Glu Glu Glu Leu Met Thr Leu Pro Gly Val Thr Arg Ala Val
    50                  55                  60                  
Ala Arg Ser Ile Val Glu Tyr Arg Glu Tyr Ile Gly Gly Phe Lys Lys
65                  70                  75                  80  
Val Glu Asp Leu Ala Leu Val Ser Gly Val Gly Ala Thr Lys Leu Glu
                85                  90                  95      
Gln Val Lys Phe Glu Ile Cys Val Ser Ser Lys Gly Ser Ser Ala Gln
            100                 105                 110         
His Ser Pro Ser Ser Leu Arg Arg Asp Leu Leu Ala Glu Gln Gln Pro
        115                 120                 125             
His His Leu Ala Thr Ala Val Pro Leu Thr Pro Arg Val Asn Ile Asn
    130                 135                 140                 
Thr Ala Thr Pro Ala Gln Leu Met Ser Val Arg Gly Leu Ser Glu Lys
145                 150                 155                 160 
Met Ala Leu Ser Ile Val Asp Phe Arg Arg Glu His Gly Pro Phe Arg
                165                 170                 175     
Ser Val Glu Asp Leu Val Arg Met Asp Gly Ile Asn Ala Ala Phe Leu
            180                 185                 190         
Asp Arg Ile Arg His Gln Val Phe Ala Glu Arg Ser Arg Pro Pro Ser
        195                 200                 205             
Thr His Thr Asn Gly Gly Leu Thr Phe Thr Ala Lys Pro His Pro Ser
    210                 215                 220                 
Pro Thr Ser Leu Ser Leu Gln Ser Glu Asp Leu Asp Leu Pro Pro Gly
225                 230                 235                 240 
Gly Pro Thr Gln Ile Ile Ser Thr Arg Pro Ser Val Glu Ala Phe Gly
                245                 250                 255     
Gly Thr Arg Asp Gly Arg Pro Val Leu Arg Leu Ala Thr Trp Asn Leu
            260                 265                 270         
Gln Gly Cys Ser Val Glu Lys Ala Asn Asn Pro Gly Val Arg Glu Val
        275                 280                 285             
Val Cys Met Thr Leu Leu Glu Asn Ser Ile Lys Leu Leu Ala Val Gln
    290                 295                 300                 
Glu Leu Leu Asp Arg Glu Ala Leu Glu Lys Phe Cys Thr Glu Leu Asn
305                 310                 315                 320 
Gln Pro Thr Leu Pro Asn Ile Arg Lys Trp Lys Gly Pro Arg Gly Cys
                325                 330                 335     
Trp Lys Ala Val Val Ala Glu Lys Pro Ser Asn Gln Leu Gln Lys Gly
            340                 345                 350         
Ala Gly Tyr Ala Gly Phe Leu Trp Asp Ala Ala Ala Gly Met Glu Leu
        355                 360                 365             
Arg Asp Ala Gly Ser Gln Glu Ser Ser Pro Ser Asn Gly His Gly Lys
    370                 375                 380                 
Leu Ala Gly Pro Ser Pro Tyr Leu Gly Arg Phe Lys Val Gly Ser His
385                 390                 395                 400 
Asp Leu Thr Leu Val Asn Leu His Leu Ala Ala Leu Thr Leu Leu Gly
                405                 410                 415     
Ser Glu Asn Pro Ser Lys Asn His Ser Asp Gly His Arg Leu Ala Ser
            420                 425                 430         
Phe Ala Gln Thr Leu Gln Glu Thr Leu Lys Gly Glu Lys Asp Val Ile
        435                 440                 445             
Ile Leu Gly Asp Phe Gly Gln Gly Pro Asp Ser Asn Asp Tyr Asp Ile
    450                 455                 460                 
Leu Arg Lys Glu Lys Phe His His Leu Ile Pro Ala His Thr Phe Thr
465                 470                 475                 480 
Asn Ile Ser Thr Lys Asn Pro Gln Gly Ser Lys Ser Leu Asp Asn Ile
                485                 490                 495     
Trp Ile Ser Lys Ser Leu Lys Lys Val Phe Thr Gly His Trp Ala Val
            500                 505                 510         
Val Arg Glu Gly Leu Thr Asn Pro Trp Ile Pro Asp Asn Trp Ser Trp
        515                 520                 525             
Gly Gly Val Ala Ser Glu His Cys Pro Val Leu Ala Glu Phe Tyr Thr
    530                 535                 540                 
Glu Lys Asp Trp Ser Lys Lys Asp Ala Pro Arg Asn Gly Ser Gly Val
545                 550                 555                 560 
Ala Leu Glu Arg Ser Glu Ala Asn Ile Lys His Glu Arg
                565                 570             


<210> 8341
<211> 2154
<212> PRT
<213> Homo sapiens

<400> 8341
Val Asp Val Ile Thr Pro Leu Lys Asp Val Asn Val Ile Glu Gly Thr
 1               5                  10                  15      
Lys Ala Val Leu Glu Cys Lys Val Ser Val Pro Asp Val Thr Ser Val
            20                  25                  30          
Lys Trp Tyr Leu Asn Asp Glu Gln Ile Lys Pro Asp Asp Arg Val Gln
        35                  40                  45              
Ala Ile Val Lys Gly Thr Lys Gln Arg Leu Val Ile Asn Arg Thr His
    50                  55                  60                  
Ala Ser Asp Glu Gly Pro Tyr Lys Leu Ile Val Gly Arg Val Glu Thr
65                  70                  75                  80  
Asn Cys Asn Leu Ser Val Glu Lys Ile Lys Ile Ile Arg Gly Leu Arg
                85                  90                  95      
Asp Leu Thr Cys Thr Glu Thr Gln Asn Val Val Phe Glu Val Glu Leu
            100                 105                 110         
Ser His Ser Gly Ile Asp Val Leu Trp Asn Phe Lys Asp Lys Glu Ile
        115                 120                 125             
Lys Pro Ser Ser Lys Tyr Lys Ile Glu Ala His Gly Lys Ile Tyr Lys
    130                 135                 140                 
Leu Thr Val Leu Asn Met Met Lys Asp Asp Glu Gly Lys Tyr Thr Phe
145                 150                 155                 160 
Tyr Ala Gly Glu Asn Ile Thr Ser Gly Lys Leu Thr Val Ala Gly Gly
                165                 170                 175     
Ala Ile Ser Lys Pro Leu Thr Asp Gln Thr Val Ala Glu Ser Gln Glu
            180                 185                 190         
Ala Val Phe Glu Cys Glu Val Ala Asn Pro Asp Ser Lys Gly Glu Trp
        195                 200                 205             
Leu Arg Asp Gly Lys His Leu Pro Leu Thr Asn Asn Ile Arg Ser Glu
    210                 215                 220                 
Ser Asp Gly His Lys Arg Arg Leu Ile Ile Ala Ala Thr Lys Leu Asp
225                 230                 235                 240 
Asp Ile Gly Glu Tyr Thr Tyr Lys Val Ala Thr Ser Lys Thr Ser Ala
                245                 250                 255     
Lys Leu Lys Val Glu Ala Val Lys Ile Lys Lys Thr Leu Lys Asn Leu
            260                 265                 270         
Thr Val Thr Glu Thr Gln Asp Ala Val Phe Thr Val Glu Leu Thr His
        275                 280                 285             
Pro Asn Val Lys Gly Val Gln Trp Ile Lys Asn Gly Val Val Leu Glu
    290                 295                 300                 
Ser Asn Glu Lys Tyr Ala Ile Ser Val Lys Gly Thr Ile Tyr Ser Leu
305                 310                 315                 320 
Arg Ile Lys Asn Cys Ala Ile Val Asp Glu Ser Val Tyr Gly Phe Arg
                325                 330                 335     
Leu Gly Arg Leu Gly Ala Ser Ala Arg Leu His Val Glu Thr Val Lys
            340                 345                 350         
Ile Ile Lys Lys Pro Lys Asp Val Thr Ala Leu Glu Asn Ala Thr Val
        355                 360                 365             
Ala Phe Glu Val Ser Val Ser His Asp Thr Val Pro Val Lys Trp Phe
    370                 375                 380                 
His Lys Asn Val Glu Ile Lys Pro Ser Asp Lys His Arg Leu Val Ser
385                 390                 395                 400 
Glu Arg Lys Val His Lys Leu Met Leu Gln Asn Ile Ser Pro Ser Asp
                405                 410                 415     
Ala Gly Glu Tyr Thr Ala Val Val Gly Gln Leu Glu Cys Lys Ala Lys
            420                 425                 430         
Leu Phe Val Glu Thr Leu His Ile Thr Lys Thr Met Lys Asn Ile Glu
        435                 440                 445             
Val Pro Glu Thr Lys Thr Ala Ser Phe Glu Cys Glu Val Ser His Phe
    450                 455                 460                 
Asn Val Pro Ser Met Trp Leu Lys Asn Gly Val Glu Ile Glu Met Ser
465                 470                 475                 480 
Glu Lys Phe Lys Ile Val Val Gln Gly Lys Leu His Gln Leu Ile Ile
                485                 490                 495     
Met Asn Thr Ser Thr Glu Asp Ser Ala Glu Tyr Thr Phe Val Cys Gly
            500                 505                 510         
Asn Asp Gln Val Ser Ala Thr Leu Thr Val Thr Pro Ile Met Ile Thr
        515                 520                 525             
Ser Met Leu Lys Asp Ile Asn Ala Glu Glu Lys Asp Thr Ile Thr Phe
    530                 535                 540                 
Glu Val Thr Val Asn Tyr Glu Gly Ile Ser Tyr Lys Trp Leu Lys Asn
545                 550                 555                 560 
Gly Val Glu Ile Lys Ser Thr Asp Lys Cys Gln Met Arg Thr Lys Lys
                565                 570                 575     
Leu Thr His Ser Leu Asn Ile Arg Asn Val His Phe Gly Asp Ala Ala
            580                 585                 590         
Asp Tyr Thr Phe Val Ala Gly Lys Ala Thr Ser Thr Ala Thr Leu Tyr
        595                 600                 605             
Val Glu Ala Arg His Ile Glu Phe Arg Lys His Ile Lys Asp Ile Lys
    610                 615                 620                 
Val Leu Glu Lys Lys Arg Ala Met Phe Glu Cys Glu Val Ser Glu Pro
625                 630                 635                 640 
Asp Ile Thr Val Gln Trp Met Lys Asp Asp Gln Glu Leu Gln Ile Thr
                645                 650                 655     
Asp Arg Ile Lys Ile Gln Lys Glu Lys Tyr Val His Arg Leu Leu Ile
            660                 665                 670         
Pro Ser Thr Arg Met Ser Asp Ala Gly Lys Tyr Thr Val Val Ala Gly
        675                 680                 685             
Gly Asn Val Ser Thr Ala Lys Leu Phe Val Glu Gly Arg Asp Val Arg
    690                 695                 700                 
Ile Arg Ser Ile Lys Lys Glu Val Gln Val Ile Glu Lys Gln Arg Ala
705                 710                 715                 720 
Val Val Glu Phe Glu Val Asn Glu Asp Asp Val Asp Ala His Trp Tyr
                725                 730                 735     
Lys Asp Gly Ile Glu Ile Asn Phe Gln Val Gln Glu Arg His Lys Tyr
            740                 745                 750         
Val Val Glu Arg Arg Ile His Arg Met Phe Ile Ser Glu Thr Arg Gln
        755                 760                 765             
Ser Asp Ala Gly Glu Tyr Thr Phe Val Ala Gly Arg Asn Arg Ser Ser
    770                 775                 780                 
Val Thr Leu Tyr Val Asn Ala Pro Glu Pro Pro Gln Val Leu Gln Glu
785                 790                 795                 800 
Leu Gln Pro Val Thr Val Gln Ser Gly Lys Pro Ala Arg Phe Cys Ala
                805                 810                 815     
Val Ile Ser Gly Arg Pro Gln Pro Lys Ile Ser Trp Tyr Lys Glu Glu
            820                 825                 830         
Gln Leu Leu Ser Thr Gly Phe Lys Cys Lys Phe Leu His Asp Gly Gln
        835                 840                 845             
Glu Tyr Thr Leu Leu Leu Ile Glu Ala Phe Pro Glu Asp Ala Ala Val
    850                 855                 860                 
Tyr Thr Cys Glu Ala Lys Asn Asp Tyr Gly Val Ala Thr Thr Ser Ala
865                 870                 875                 880 
Ser Leu Ser Val Glu Val Pro Glu Val Val Ser Pro Asp Gln Glu Met
                885                 890                 895     
Pro Val Tyr Pro Pro Ala Ile Ile Thr Pro Leu Gln Asp Thr Val Thr
            900                 905                 910         
Ser Glu Gly Gln Pro Ala Arg Phe Gln Cys Arg Val Ser Gly Thr Asp
        915                 920                 925             
Leu Lys Val Ser Trp Tyr Ser Lys Asp Lys Lys Ile Lys Pro Ser Arg
    930                 935                 940                 
Phe Phe Arg Met Thr Gln Phe Glu Asp Thr Tyr Gln Leu Glu Ile Ala
945                 950                 955                 960 
Glu Ala Tyr Pro Glu Asp Glu Gly Thr Tyr Thr Phe Val Ala Ser Asn
                965                 970                 975     
Ala Val Gly Gln Val Ser Ser Thr Ala Asn Leu Ser Leu Glu Gly Phe
            980                 985                 990         
Ser Lys Phe Glu Glu Asn Thr Ser Asn Ser Gln Trp His Val Ser Leu
        995                 1000                1005            
Ser Val Ser Phe Lys Lys Glu Pro Leu Gly Gln Lys Pro Ser Phe Ile
    1010                1015                1020                
Gln Pro Leu Ser Ser Leu Arg Val His Asn Gly Glu Thr Val Arg Phe
1025                1030                1035                1040
His Ala Arg Val Ser Gly Ile Pro Lys Pro Glu Ile Gln Trp Phe His
                1045                1050                1055    
Asn Gln Gln Leu Ile Leu Pro Thr Lys Asp Val Val Phe His Phe Glu
            1060                1065                1070        
Glu Ser Thr Gly Met Ala Leu Met Leu Ile Val Asp Ala Tyr Ser Glu
        1075                1080                1085            
His Ala Gly Gln Tyr Ser Cys Lys Ala Ala Asn Ser Ala Gly Glu Ala
    1090                1095                1100                
Thr Cys Ala Ala Thr Leu Thr Val Thr Pro Lys Ala Pro Glu Ser Ile
1105                1110                1115                1120
Leu His Glu Arg Ile Glu Gln Glu Ile Glu Met Glu Met Lys Glu Phe
                1125                1130                1135    
Ser Ser Ser Phe Leu Ser Ala Glu Glu Glu Gly Leu His Ser Ala Glu
            1140                1145                1150        
Leu Gln Leu Ser Lys Ile Asn Glu Thr Leu Glu Leu Leu Ser Glu Ser
        1155                1160                1165            
Pro Val Tyr Ser Thr Lys Phe Asp Ser Glu Lys Glu Gly Thr Gly Pro
    1170                1175                1180                
Ile Phe Ile Lys Glu Val Ser Asn Ala Asp Ile Ser Met Gly Asp Val
1185                1190                1195                1200
Ala Thr Leu Ser Val Thr Val Ile Gly Ile Pro Lys Pro Lys Ile Gln
                1205                1210                1215    
Trp Phe Phe Asn Gly Val Leu Leu Thr Pro Ser Ala Asp Tyr Lys Phe
            1220                1225                1230        
Val Phe Asp Gly Asp Asp His Ser Leu Ile Ile Leu Phe Thr Lys Leu
        1235                1240                1245            
Glu Asp Glu Gly Glu Tyr Thr Cys Met Ala Ser Asn Asp Tyr Gly Lys
    1250                1255                1260                
Thr Ile Cys Ser Ala Tyr Leu Lys Ile Asn Ser Lys Gly Glu Gly His
1265                1270                1275                1280
Lys Asp Thr Glu Thr Glu Ser Ala Val Ala Lys Ser Leu Glu Lys Leu
                1285                1290                1295    
Gly Gly Pro Cys Pro Pro His Phe Leu Lys Glu Leu Lys Pro Ile Arg
            1300                1305                1310        
Cys Ala Gln Gly Leu Pro Ala Ile Phe Glu Tyr Thr Val Val Gly Glu
        1315                1320                1325            
Pro Ala Pro Thr Val Thr Trp Phe Lys Glu Asn Lys Gln Leu Cys Thr
    1330                1335                1340                
Ser Val Tyr Tyr Thr Ile Ile His Asn Pro Asn Gly Ser Gly Thr Phe
1345                1350                1355                1360
Ile Val Asn Asp Pro Gln Arg Glu Asp Ser Gly Leu Tyr Ile Cys Lys
                1365                1370                1375    
Ala Glu Asn Met Leu Gly Glu Ser Thr Cys Ala Ala Glu Leu Leu Val
            1380                1385                1390        
Leu Leu Glu Asp Thr Asp Met Thr Asp Thr Pro Cys Lys Ala Lys Ser
        1395                1400                1405            
Thr Pro Glu Ala Pro Glu Asp Phe Pro Gln Thr Pro Leu Lys Gly Pro
    1410                1415                1420                
Ala Val Glu Ala Leu Asp Ser Glu Gln Glu Ile Ala Thr Phe Val Lys
1425                1430                1435                1440
Asp Thr Ile Leu Lys Ala Ala Leu Ile Thr Glu Glu Asn Gln Gln Leu
                1445                1450                1455    
Ser Tyr Glu His Ile Ala Lys Ala Asn Glu Leu Ser Ser Gln Leu Pro
            1460                1465                1470        
Leu Gly Ala Gln Glu Leu Gln Ser Ile Leu Glu Gln Asp Lys Leu Thr
        1475                1480                1485            
Pro Glu Ser Thr Arg Glu Phe Leu Cys Ile Asn Gly Ser Ile His Phe
    1490                1495                1500                
Gln Pro Leu Lys Glu Pro Ser Pro Asn Leu Gln Leu Gln Ile Val Gln
1505                1510                1515                1520
Ser Gln Lys Thr Phe Ser Lys Glu Gly Ile Leu Met Pro Glu Glu Pro
                1525                1530                1535    
Glu Thr Gln Ala Val Leu Ser Asp Thr Glu Lys Ile Phe Pro Ser Ala
            1540                1545                1550        
Met Ser Ile Glu Gln Ile Asn Ser Leu Thr Val Glu Pro Leu Lys Thr
        1555                1560                1565            
Leu Leu Ala Glu Pro Glu Gly Asn Tyr Pro Gln Ser Ser Ile Glu Pro
    1570                1575                1580                
Pro Met His Ser Tyr Leu Thr Ser Val Ala Glu Glu Val Leu Ser Pro
1585                1590                1595                1600
Lys Glu Lys Thr Val Ser Asp Thr Asn Arg Glu Gln Arg Val Thr Leu
                1605                1610                1615    
Gln Lys Gln Glu Ala Gln Ser Ala Leu Ile Leu Ser Gln Ser Leu Ala
            1620                1625                1630        
Glu Gly His Val Glu Ser Leu Gln Ser Pro Asp Val Met Ile Ser Gln
        1635                1640                1645            
Val Asn Tyr Glu Pro Leu Val Pro Ser Glu His Ser Cys Thr Glu Gly
    1650                1655                1660                
Gly Lys Ile Leu Ile Glu Ser Ala Asn Pro Leu Glu Asn Ala Gly Gln
1665                1670                1675                1680
Asp Ser Ala Val Arg Ile Glu Glu Gly Lys Ser Leu Arg Phe Pro Leu
                1685                1690                1695    
Ala Leu Glu Glu Lys Gln Val Leu Leu Lys Glu Glu His Ser Asp Asn
            1700                1705                1710        
Val Val Met Pro Pro Asp Gln Ile Ile Glu Ser Lys Arg Glu Pro Val
        1715                1720                1725            
Ala Ile Lys Lys Val Gln Glu Val Gln Gly Arg Asp Leu Leu Ser Lys
    1730                1735                1740                
Glu Ser Leu Leu Ser Gly Ile Pro Glu Glu Gln Arg Leu Asn Leu Lys
1745                1750                1755                1760
Ile Gln Ile Cys Arg Ala Leu Gln Ala Ala Val Ala Ser Glu Gln Pro
                1765                1770                1775    
Gly Leu Phe Ser Glu Trp Leu Arg Asn Ile Glu Lys Val Glu Val Glu
            1780                1785                1790        
Ala Val Asn Ile Thr Gln Glu Pro Arg His Ile Met Cys Met Tyr Leu
        1795                1800                1805            
Val Thr Ser Ala Lys Ser Val Thr Glu Glu Val Thr Ile Ile Ile Glu
    1810                1815                1820                
Asp Val Asp Pro Gln Met Ala Asn Leu Lys Met Glu Leu Arg Asp Ala
1825                1830                1835                1840
Leu Cys Ala Ile Ile Tyr Glu Glu Ile Asp Ile Leu Thr Ala Glu Gly
                1845                1850                1855    
Pro Arg Ile Gln Gln Gly Ala Lys Thr Ser Leu Gln Glu Glu Met Asp
            1860                1865                1870        
Ser Phe Ser Gly Ser Gln Lys Val Glu Pro Ile Thr Glu Pro Glu Val
        1875                1880                1885            
Glu Ser Lys Tyr Leu Ile Ser Pro Glu Glu Val Ser Tyr Phe Asn Val
    1890                1895                1900                
Gln Ser Arg Val Lys Tyr Leu Asp Ala Thr Pro Val Thr Lys Gly Val
1905                1910                1915                1920
Ala Ser Ala Val Val Ser Asp Glu Lys Gln Asp Glu Ser Leu Lys Pro
                1925                1930                1935    
Ser Glu Glu Lys Glu Glu Ser Ser Ser Glu Ser Gly Thr Glu Glu Val
            1940                1945                1950        
Ala Thr Val Lys Ile Gln Glu Ala Glu Gly Gly Phe Ile Lys Glu Asp
        1955                1960                1965            
Gly Pro Met Ile His Thr Pro Leu Val Asp Thr Val Ser Glu Glu Gly
    1970                1975                1980                
Asp Ile Val His Leu Thr Thr Ser Ile Thr Asn Ala Lys Glu Val Asn
1985                1990                1995                2000
Trp Tyr Phe Glu Asn Lys Leu Val Pro Ser Asp Glu Lys Phe Lys Cys
                2005                2010                2015    
Leu Gln Asp Gln Asn Thr Tyr Thr Leu Val Ile Asp Lys Val Asn Thr
            2020                2025                2030        
Glu Asp His Gln Gly Glu Tyr Val Cys Glu Ala Leu Asn Asp Ser Gly
        2035                2040                2045            
Lys Thr Ala Thr Ser Ala Lys Leu Thr Val Val Lys Arg Ala Ala Pro
    2050                2055                2060                
Val Ile Lys Arg Lys Ile Glu Pro Leu Glu Val Ala Leu Gly His Leu
2065                2070                2075                2080
Ala Lys Phe Thr Cys Glu Ile Gln Ser Ala Pro Asn Val Arg Phe Gln
                2085                2090                2095    
Trp Phe Lys Ala Gly Arg Glu Ile Tyr Glu Ser Asp Lys Cys Ser Ile
            2100                2105                2110        
Arg Ser Ser Lys Tyr Ile Ser Ser Leu Glu Ile Leu Arg Thr Gln Val
        2115                2120                2125            
Val Asp Cys Gly Glu Tyr Thr Cys Lys Ala Ser Asn Glu Tyr Gly Ser
    2130                2135                2140                
Val Ser Cys Thr Ala Thr Leu Thr Val Thr
2145                2150                


<210> 8342
<211> 356
<212> PRT
<213> Homo sapiens

<400> 8342
Met Leu Leu Gly Phe Arg Arg Gly Arg Arg Ser His Phe Lys His Ile
 1               5                  10                  15      
Ile His Gly Leu Leu Pro Ala Ala Ser Val Ala Pro Lys Ala Ala Val
            20                  25                  30          
Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser Pro Glu Arg Pro
        35                  40                  45              
Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr Leu Thr Gly Arg
    50                  55                  60                  
Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg Ser Glu Ser Asp
65                  70                  75                  80  
Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro Tyr Ala Thr Thr
                85                  90                  95      
Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu Met Gly Arg Arg
            100                 105                 110         
Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly Asp Glu Glu Asp
        115                 120                 125             
Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu Gly Asp Val Ser
    130                 135                 140                 
Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu Tyr Ala Val Pro
145                 150                 155                 160 
His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn Ser Glu Asp Asp
                165                 170                 175     
Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser Pro Pro Ala Pro
            180                 185                 190         
Gln Arg Thr Gln Gln Lys Asp Gly Lys His Pro Val Leu Asn Leu Lys
        195                 200                 205             
Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro Ser Pro Asp Ile
    210                 215                 220                 
Thr Gly Arg Ala Arg Gln Arg Tyr Thr Glu Ile Thr Arg Glu Lys Phe
225                 230                 235                 240 
Glu Ala Leu Lys Glu Glu Asn Met Asp Leu Asn Asn Met Asn Gln Ser
                245                 250                 255     
Leu Thr Leu Glu Leu Asn Thr Met Lys Gln Ala Met Lys Glu Leu Gln
            260                 265                 270         
Leu Lys Leu Lys Gly Met Glu Lys Glu Lys Arg Lys Leu Lys Glu Ala
        275                 280                 285             
Glu Lys Ala Ser Ser Gln Glu Val Ala Ala Pro Glu Leu Leu Tyr Leu
    290                 295                 300                 
Arg Lys Gln Ala Gln Glu Leu Val Asp Glu Asn Asp Gly Leu Lys Met
305                 310                 315                 320 
Thr Val His Arg Leu Asn Val Glu Leu Ser Arg Tyr Gln Thr Lys Phe
                325                 330                 335     
Arg His Leu Ser Lys Glu Glu Val Thr Phe Pro Ile Val Lys Ile Ser
            340                 345                 350         
Phe Ser Asp Phe
        355     


<210> 8343
<211> 1338
<212> PRT
<213> Homo sapiens

<400> 8343
Met Ser Pro Val Leu His Phe Tyr Val Arg Pro Ser Gly His Glu Gly
 1               5                  10                  15      
Ala Ala Ser Gly His Thr Arg Arg Lys Leu Gln Gly Lys Leu Pro Glu
            20                  25                  30          
Leu Gln Gly Val Glu Thr Glu Leu Cys Tyr Asn Val Asn Trp Thr Ala
        35                  40                  45              
Glu Ala Leu Pro Ser Ala Glu Glu Thr Lys Lys Leu Met Trp Leu Phe
    50                  55                  60                  
Gly Cys Pro Leu Leu Leu Asp Asp Val Ala Arg Glu Ser Trp Leu Leu
65                  70                  75                  80  
Pro Gly Ser Asn Asp Leu Leu Leu Glu Val Gly Pro Arg Leu Asn Phe
                85                  90                  95      
Ser Thr Pro Thr Ser Thr Asn Ile Val Ser Val Cys Arg Ala Thr Gly
            100                 105                 110         
Leu Gly Pro Val Asp Arg Val Glu Thr Thr Arg Arg Tyr Arg Leu Ser
        115                 120                 125             
Phe Ala His Pro Pro Ser Ala Glu Val Glu Ala Ile Ala Leu Ala Thr
    130                 135                 140                 
Leu His Asp Arg Met Thr Glu Gln His Phe Pro His Pro Ile Gln Ser
145                 150                 155                 160 
Phe Ser Pro Glu Ser Met Pro Glu Pro Leu Asn Gly Pro Ile Asn Ile
                165                 170                 175     
Leu Gly Glu Gly Arg Leu Ala Leu Glu Lys Ala Asn Gln Glu Leu Gly
            180                 185                 190         
Leu Ala Leu Asp Ser Trp Asp Leu Asp Phe Tyr Thr Lys Arg Phe Gln
        195                 200                 205             
Glu Leu Gln Arg Asn Pro Ser Thr Val Glu Ala Phe Asp Leu Ala Gln
    210                 215                 220                 
Ser Asn Ser Glu His Ser Arg His Trp Phe Phe Lys Gly Gln Leu His
225                 230                 235                 240 
Val Asp Gly Gln Lys Leu Val His Ser Leu Phe Glu Ser Ile Met Ser
                245                 250                 255     
Thr Gln Glu Ser Ser Asn Pro Asn Asn Val Leu Lys Phe Cys Asp Asn
            260                 265                 270         
Ser Ser Ala Ile Gln Gly Lys Glu Val Arg Phe Leu Arg Pro Glu Asp
        275                 280                 285             
Pro Thr Arg Pro Ser Arg Phe Gln Gln Gln Gln Gly Leu Arg His Val
    290                 295                 300                 
Val Phe Thr Ala Glu Thr His Asn Phe Pro Thr Gly Val Cys Pro Phe
305                 310                 315                 320 
Ser Gly Ala Thr Thr Gly Thr Gly Gly Arg Ile Arg Asp Val Gln Cys
                325                 330                 335     
Thr Gly Arg Gly Ala His Val Val Ala Gly Thr Ala Gly Tyr Cys Phe
            340                 345                 350         
Gly Asn Leu His Ile Pro Gly Tyr Asn Leu Pro Trp Glu Asp Leu Ser
        355                 360                 365             
Phe Gln Tyr Pro Gly Asn Phe Ala Arg Pro Leu Glu Val Ala Ile Glu
    370                 375                 380                 
Ala Ser Asn Gly Ala Ser Asp Tyr Gly Asn Lys Phe Gly Glu Pro Val
385                 390                 395                 400 
Leu Ala Gly Phe Ala Arg Ser Leu Gly Leu Gln Leu Pro Asp Gly Gln
                405                 410                 415     
Arg Arg Glu Trp Ile Lys Pro Ile Met Phe Ser Gly Gly Ile Gly Ser
            420                 425                 430         
Met Glu Ala Asp His Ile Ser Lys Glu Ala Pro Glu Pro Gly Met Glu
        435                 440                 445             
Val Val Lys Val Gly Gly Pro Val Tyr Arg Ile Gly Val Gly Gly Gly
    450                 455                 460                 
Ala Ala Ser Ser Val Gln Val Gln Gly Asp Asn Thr Ser Asp Leu Asp
465                 470                 475                 480 
Phe Gly Ala Val Gln Arg Gly Asp Pro Glu Met Glu Gln Lys Met Asn
                485                 490                 495     
Arg Val Ile Arg Ala Cys Val Glu Ala Pro Lys Gly Asn Pro Ile Cys
            500                 505                 510         
Ser Leu His Asp Gln Gly Ala Gly Gly Asn Gly Asn Val Leu Lys Glu
        515                 520                 525             
Leu Ser Asp Pro Ala Gly Ala Ile Ile Tyr Thr Ser Arg Phe Gln Leu
    530                 535                 540                 
Gly Asp Pro Thr Leu Asn Ala Leu Glu Ile Trp Gly Ala Glu Tyr Gln
545                 550                 555                 560 
Glu Ser Asn Ala Leu Leu Leu Arg Ser Pro Asn Arg Asp Phe Leu Thr
                565                 570                 575     
His Val Ser Ala Arg Glu Arg Cys Pro Ala Cys Phe Val Gly Thr Ile
            580                 585                 590         
Thr Gly Asp Arg Arg Ile Val Leu Val Asp Asp Arg Glu Cys Pro Val
        595                 600                 605             
Arg Arg Asn Gly Gln Gly Asp Ala Pro Pro Thr Pro Pro Pro Thr Pro
    610                 615                 620                 
Val Asp Leu Glu Leu Glu Trp Val Leu Gly Lys Met Pro Arg Lys Glu
625                 630                 635                 640 
Phe Phe Leu Gln Arg Lys Pro Pro Met Leu Gln Pro Leu Ala Leu Pro
                645                 650                 655     
Pro Gly Leu Ser Val His Gln Ala Leu Glu Arg Val Leu Arg Leu Pro
            660                 665                 670         
Ala Val Ala Ser Lys Arg Tyr Leu Thr Asn Lys Val Asp Arg Ser Val
        675                 680                 685             
Gly Gly Leu Val Ala Gln Gln Gln Cys Val Gly Pro Leu Gln Thr Pro
    690                 695                 700                 
Leu Ala Asp Val Ala Val Val Ala Leu Ser His Glu Glu Leu Ile Gly
705                 710                 715                 720 
Ala Ala Thr Ala Leu Gly Glu Gln Pro Val Lys Ser Leu Leu Asp Pro
                725                 730                 735     
Lys Val Ala Ala Arg Leu Ala Val Ala Glu Ala Leu Thr Asn Leu Val
            740                 745                 750         
Phe Ala Leu Val Thr Asp Leu Arg Asp Val Lys Cys Ser Gly Asn Trp
        755                 760                 765             
Met Trp Ala Ala Lys Leu Pro Gly Glu Gly Ala Ala Leu Ala Asp Ala
    770                 775                 780                 
Cys Glu Ala Met Val Ala Val Met Ala Ala Leu Gly Val Ala Val Asp
785                 790                 795                 800 
Gly Gly Lys Asp Ser Leu Ser Met Ala Ala Arg Val Gly Thr Glu Thr
                805                 810                 815     
Val Arg Ala Pro Gly Ser Leu Val Ile Ser Ala Tyr Ala Val Cys Pro
            820                 825                 830         
Asp Ile Thr Ala Thr Val Thr Pro Asp Leu Lys His Pro Glu Gly Arg
        835                 840                 845             
Gly His Leu Leu Tyr Val Ala Leu Ser Pro Gly Gln His Arg Leu Gly
    850                 855                 860                 
Gly Thr Ala Leu Ala Gln Cys Phe Ser Gln Leu Gly Glu His Pro Pro
865                 870                 875                 880 
Asp Leu Asp Leu Pro Glu Asn Leu Val Arg Ala Phe Ser Ile Thr Gln
                885                 890                 895     
Gly Leu Leu Lys Asp Arg Leu Leu Cys Ser Gly His Asp Val Ser Asp
            900                 905                 910         
Gly Gly Leu Val Thr Cys Leu Leu Glu Met Ala Phe Ala Gly Asn Cys
        915                 920                 925             
Gly Leu Gln Val Asp Val Pro Val Pro Arg Val Asp Val Leu Ser Val
    930                 935                 940                 
Leu Phe Ala Glu Glu Pro Gly Leu Val Leu Glu Val Gln Glu Pro Asp
945                 950                 955                 960 
Leu Ala Gln Val Leu Lys Arg Tyr Arg Asp Ala Gly Leu His Cys Leu
                965                 970                 975     
Glu Leu Gly His Thr Gly Glu Ala Gly Pro His Ala Met Val Arg Val
            980                 985                 990         
Ser Val Asn Gly Ala Val Val Leu Glu Glu Pro Val Gly Glu Leu Arg
        995                 1000                1005            
Ala Leu Trp Glu Glu Thr Ser Phe Gln Leu Asp Arg Leu Gln Ala Glu
    1010                1015                1020                
Pro Arg Cys Val Ala Glu Glu Glu Arg Gly Leu Arg Glu Arg Met Gly
1025                1030                1035                1040
Pro Ser Tyr Cys Leu Pro Pro Thr Phe Pro Lys Ala Ser Val Pro Arg
                1045                1050                1055    
Glu Pro Gly Gly Pro Ser Pro Arg Val Ala Ile Leu Arg Glu Glu Gly
            1060                1065                1070        
Ser Asn Gly Asp Arg Glu Met Ala Asp Ala Phe His Leu Ala Gly Phe
        1075                1080                1085            
Glu Val Trp Asp Val Thr Met Gln Asp Leu Cys Ser Gly Ala Ile Gly
    1090                1095                1100                
Leu Asp Thr Phe Arg Gly Val Ala Phe Val Gly Gly Phe Ser Tyr Ala
1105                1110                1115                1120
Asp Val Leu Gly Ser Ala Lys Gly Trp Ala Ala Ala Val Thr Phe His
                1125                1130                1135    
Pro Arg Ala Gly Ala Glu Leu Arg Arg Phe Arg Lys Arg Pro Asp Thr
            1140                1145                1150        
Phe Ser Leu Gly Val Cys Asn Gly Cys Gln Leu Leu Ala Leu Leu Gly
        1155                1160                1165            
Trp Val Gly Gly Asp Pro Asn Glu Asp Ala Ala Glu Met Gly Pro Asp
    1170                1175                1180                
Ser Gln Pro Ala Arg Pro Gly Leu Leu Leu Arg His Asn Leu Ser Gly
1185                1190                1195                1200
Arg Tyr Glu Ser Arg Trp Ala Ser Val Arg Val Gly Pro Gly Pro Ala
                1205                1210                1215    
Leu Met Leu Arg Gly Met Glu Gly Ala Val Leu Pro Val Trp Ser Ala
            1220                1225                1230        
His Gly Glu Gly Tyr Val Ala Phe Ser Ser Pro Glu Leu Gln Ala Gln
        1235                1240                1245            
Ile Glu Ala Arg Gly Leu Ala Pro Leu His Trp Ala Asp Asp Asp Gly
    1250                1255                1260                
Asn Pro Thr Glu Gln Tyr Pro Leu Asn Pro Asn Gly Ser Pro Gly Gly
1265                1270                1275                1280
Val Ala Gly Ile Cys Ser Cys Asp Gly Arg His Leu Ala Val Met Pro
                1285                1290                1295    
His Pro Glu Arg Ala Val Arg Pro Trp Gln Trp Ala Trp Arg Pro Pro
            1300                1305                1310        
Pro Phe Asp Thr Leu Thr Thr Ser Pro Trp Leu Gln Leu Ser Ile Asn
        1315                1320                1325            
Ala Arg Asn Trp Thr Leu Glu Gly Ser Cys
    1330                1335            


<210> 8344
<211> 279
<212> PRT
<213> Homo sapiens

<400> 8344
Met Val Arg Lys Glu Tyr Pro Asn Leu Ser Thr Ser Leu Asp Asp Ala
 1               5                  10                  15      
Phe Leu Leu Arg Phe Leu Arg Ala Arg Lys Phe Asp Tyr Asp Arg Ala
            20                  25                  30          
Leu Gln Leu Leu Val Asn Tyr His Ser Cys Arg Arg Ser Trp Pro Glu
        35                  40                  45              
Val Phe Asn Asn Leu Lys Pro Ser Ala Leu Lys Asp Val Leu Ala Ser
    50                  55                  60                  
Gly Phe Leu Thr Val Leu Pro His Thr Asp Pro Arg Gly Cys His Val
65                  70                  75                  80  
Val Cys Ile Arg Pro Asp Arg Trp Ile Pro Ser Asn Tyr Pro Ile Thr
                85                  90                  95      
Glu Asn Ile Arg Ala Ile Tyr Leu Thr Leu Glu Lys Leu Ile Gln Ser
            100                 105                 110         
Glu Glu Thr Gln Val Asn Gly Ile Val Ile Leu Ala Asp Tyr Lys Gly
        115                 120                 125             
Val Ser Leu Ser Lys Ala Ser His Phe Gly Pro Phe Ile Ala Lys Lys
    130                 135                 140                 
Val Ile Gly Ile Leu Gln Asp Gly Phe Pro Ile Arg Ile Lys Ala Val
145                 150                 155                 160 
His Val Val Asn Glu Pro Arg Ile Phe Lys Gly Ile Phe Ala Ile Ile
                165                 170                 175     
Lys Pro Phe Leu Lys Glu Lys Ile Ala Asn Arg Phe Phe Leu His Gly
            180                 185                 190         
Ser Asp Leu Asn Ser Leu His Thr Asn Leu Pro Arg Ser Ile Leu Pro
        195                 200                 205             
Lys Glu Tyr Gly Gly Thr Ala Gly Glu Leu Asp Thr Ala Thr Trp Asn
    210                 215                 220                 
Ala Val Leu Leu Ala Ser Glu Asp Asp Phe Val Lys Glu Phe Cys Gln
225                 230                 235                 240 
Pro Val Pro Ala Cys Asp Ser Ile Leu Gly Gln Thr Leu Leu Pro Glu
                245                 250                 255     
Gly Leu Thr Ser Asp Ala Gln Cys Asp Asp Ser Leu Arg Ala Val Lys
            260                 265                 270         
Ser Gln Leu Tyr Ser Cys Tyr
        275                 


<210> 8345
<211> 1721
<212> PRT
<213> Homo sapiens

<400> 8345
Met Leu Ser Ala Thr Pro Leu Tyr Gly Asn Val His Ser Trp Met Asn
 1               5                  10                  15      
Ser Glu Arg Val Arg Met Cys Gly Ala Ser Glu Asp Arg Lys Ile Leu
            20                  25                  30          
Val Asn Asp Gly Asp Ala Ser Lys Ala Arg Leu Glu Leu Arg Glu Glu
        35                  40                  45              
Asn Pro Leu Asn His Asn Val Val Asp Ala Ser Thr Ala His Arg Ile
    50                  55                  60                  
Asp Gly Leu Ala Ala Leu Ser Met Asp Arg Thr Gly Leu Ile Arg Glu
65                  70                  75                  80  
Gly Leu Arg Val Pro Gly Asn Ile Val Tyr Ser Ser Leu Cys Gly Leu
                85                  90                  95      
Gly Ser Glu Lys Gly Arg Glu Ala Ala Thr Ser Thr Leu Gly Gly Leu
            100                 105                 110         
Gly Phe Ser Ser Glu Arg Asn Pro Glu Met Gln Phe Lys Pro Asn Thr
        115                 120                 125             
Pro Glu Thr Val Glu Ala Ser Ala Val Ser Gly Lys Pro Pro Asn Gly
    130                 135                 140                 
Phe Ser Ala Ile Tyr Lys Thr Pro Pro Gly Ile Gln Lys Ser Ala Val
145                 150                 155                 160 
Ala Thr Ala Glu Ala Leu Gly Leu Asp Arg Pro Ala Ser Asp Lys Gln
                165                 170                 175     
Ser Pro Leu Asn Ile Asn Gly Ala Ser Tyr Leu Arg Leu Pro Trp Val
            180                 185                 190         
Asn Pro Tyr Met Glu Gly Ala Thr Pro Ala Ile Tyr Pro Phe Leu Asp
        195                 200                 205             
Ser Pro Asn Lys Tyr Ser Leu Asn Met Tyr Lys Ala Leu Leu Pro Gln
    210                 215                 220                 
Gln Ser Tyr Ser Leu Ala Gln Pro Leu Tyr Ser Pro Val Cys Thr Asn
225                 230                 235                 240 
Gly Glu Arg Phe Leu Tyr Leu Pro Pro Pro His Tyr Val Gly Pro His
                245                 250                 255     
Ile Pro Ser Ser Leu Ala Ser Pro Met Arg Leu Ser Thr Pro Ser Ala
            260                 265                 270         
Ser Pro Ala Ile Pro Pro Leu Val His Cys Ala Asp Lys Ser Leu Pro
        275                 280                 285             
Trp Lys Met Gly Val Ser Pro Gly Asn Pro Val Asp Ser His Ala Tyr
    290                 295                 300                 
Pro His Ile Gln Asn Ser Lys Gln Pro Arg Val Pro Ser Ala Lys Ala
305                 310                 315                 320 
Val Thr Ser Gly Leu Pro Gly Asp Thr Ala Leu Leu Leu Pro Pro Ser
                325                 330                 335     
Pro Arg Pro Ser Pro Arg Val His Leu Pro Thr Gln Pro Ala Ala Asp
            340                 345                 350         
Thr Tyr Ser Glu Phe His Lys His Tyr Ala Arg Ile Ser Thr Ser Pro
        355                 360                 365             
Ser Val Ala Leu Ser Lys Pro Tyr Met Thr Val Ser Ser Glu Phe Pro
    370                 375                 380                 
Ala Ala Arg Leu Ser Asn Gly Lys Tyr Pro Lys Ala Pro Glu Gly Gly
385                 390                 395                 400 
Glu Gly Ala Gln Pro Val Pro Gly His Ala Arg Lys Thr Ala Val Gln
                405                 410                 415     
Asp Arg Lys Asp Gly Ser Ser Pro Pro Leu Leu Glu Lys Gln Thr Val
            420                 425                 430         
Thr Lys Asp Val Thr Asp Lys Pro Leu Asp Leu Ser Ser Lys Val Val
        435                 440                 445             
Asp Val Asp Ala Ser Lys Ala Asp His Met Lys Lys Met Ala Pro Thr
    450                 455                 460                 
Val Leu Val His Ser Arg Ala Gly Ser Gly Leu Val Leu Ser Gly Ser
465                 470                 475                 480 
Glu Ile Pro Lys Glu Thr Leu Ser Pro Pro Gly Asn Gly Cys Ala Ile
                485                 490                 495     
Tyr Arg Ser Glu Ile Ile Ser Thr Ala Pro Ser Ser Trp Val Val Pro
            500                 505                 510         
Gly Pro Ser Pro Asn Glu Glu Asn Asn Gly Lys Ser Met Ser Leu Lys
        515                 520                 525             
Asn Lys Ala Leu Asp Trp Ala Ile Pro Gln Gln Arg Ser Ser Ser Cys
    530                 535                 540                 
Pro Arg Met Gly Gly Thr Asp Ala Val Ile Thr Asn Val Ser Gly Ser
545                 550                 555                 560 
Val Ser Ser Ala Gly Arg Pro Ala Ser Ala Ser Pro Ala Pro Asn Ala
                565                 570                 575     
Asn Ala Asp Gly Thr Lys Thr Ser Arg Ser Ser Val Glu Thr Thr Pro
            580                 585                 590         
Ser Val Ile Gln His Val Gly Gln Pro Pro Ala Thr Pro Ala Lys His
        595                 600                 605             
Ser Ser Ser Thr Ser Ser Lys Gly Ala Lys Ala Ser Asn Pro Glu Pro
    610                 615                 620                 
Ser Phe Lys Ala Asn Glu Asn Gly Leu Pro Pro Ser Ser Ile Phe Leu
625                 630                 635                 640 
Ser Pro Asn Glu Ala Phe Arg Ser Pro Pro Ile Pro Tyr Pro Arg Ser
                645                 650                 655     
Tyr Leu Pro Tyr Pro Ala Pro Glu Gly Ile Ala Val Ser Pro Leu Ser
            660                 665                 670         
Leu His Gly Lys Gly Pro Val Tyr Pro His Pro Val Leu Leu Pro Asn
        675                 680                 685             
Gly Ser Leu Phe Pro Gly His Leu Ala Pro Lys Pro Gly Leu Pro Tyr
    690                 695                 700                 
Gly Leu Pro Thr Gly Arg Pro Glu Phe Val Thr Tyr Gln Asp Ala Leu
705                 710                 715                 720 
Gly Leu Gly Met Val His Pro Met Leu Ile Pro His Thr Pro Ile Glu
                725                 730                 735     
Ile Thr Lys Glu Glu Lys Pro Glu Arg Arg Ser Arg Ser His Glu Arg
            740                 745                 750         
Ala Arg Tyr Glu Asp Pro Thr Leu Arg Asn Arg Phe Ser Glu Ile Leu
        755                 760                 765             
Glu Thr Ser Ser Thr Lys Leu His Pro Asp Val Pro Thr Asp Lys Asn
    770                 775                 780                 
Leu Lys Pro Asn Pro Asn Trp Asn Gln Gly Lys Thr Val Val Lys Ser
785                 790                 795                 800 
Asp Lys Leu Val Tyr Val Asp Leu Leu Arg Glu Glu Pro Asp Ala Lys
                805                 810                 815     
Thr Asp Thr Asn Val Ser Lys Pro Ser Phe Ala Ala Glu Ser Val Gly
            820                 825                 830         
Gln Ser Ala Glu Pro Pro Lys Pro Ser Val Glu Pro Ala Leu Gln Gln
        835                 840                 845             
His Arg Asp Phe Ile Ala Leu Arg Glu Glu Leu Gly Arg Ile Ser Asp
    850                 855                 860                 
Phe His Glu Thr Tyr Thr Phe Lys Gln Pro Val Phe Thr Val Ser Lys
865                 870                 875                 880 
Asp Ser Val Leu Ala Gly Thr Asn Lys Glu Asn Leu Gly Leu Pro Val
                885                 890                 895     
Ser Thr Pro Phe Leu Glu Pro Pro Leu Gly Ser Asp Gly Pro Ala Val
            900                 905                 910         
Thr Phe Gly Lys Thr Gln Glu Asp Pro Lys Pro Phe Cys Val Gly Ser
        915                 920                 925             
Ala Pro Pro Ser Val Asp Val Thr Pro Thr Tyr Thr Lys Asp Gly Ala
    930                 935                 940                 
Asp Glu Ala Glu Ser Asn Asp Gly Lys Val Leu Lys Pro Lys Pro Ser
945                 950                 955                 960 
Lys Leu Ala Lys Arg Ile Ala Asn Ser Ala Gly Tyr Val Gly Asp Arg
                965                 970                 975     
Phe Lys Cys Val Thr Thr Glu Leu Tyr Ala Asp Ser Ser Gln Leu Ser
            980                 985                 990         
Arg Glu Gln Arg Ala Leu Gln Met Glu Gly Leu Gln Glu Asp Ser Ile
        995                 1000                1005            
Leu Cys Leu Pro Ala Ala Tyr Cys Glu Arg Ala Met Met Arg Phe Ser
    1010                1015                1020                
Glu Leu Glu Met Lys Glu Arg Glu Gly Gly His Pro Ala Thr Lys Asp
1025                1030                1035                1040
Ser Glu Met Cys Lys Phe Ser Pro Ala Asp Trp Glu Arg Leu Lys Gly
                1045                1050                1055    
Asn Gln Asp Lys Lys Pro Lys Ser Val Thr Leu Glu Glu Ala Ile Ala
            1060                1065                1070        
Glu Gln Asn Glu Ser Glu Arg Cys Glu Tyr Ser Val Gly Asn Lys His
        1075                1080                1085            
Arg Asp Pro Phe Glu Ala Pro Glu Asp Lys Asp Leu Pro Val Glu Lys
    1090                1095                1100                
Tyr Phe Val Glu Arg Gln Pro Val Ser Glu Pro Pro Ala Asp Gln Val
1105                1110                1115                1120
Ala Ser Asp Met Pro His Ser Pro Thr Leu Arg Val Asp Arg Lys Arg
                1125                1130                1135    
Lys Val Ser Gly Asp Ser Ser His Thr Glu Thr Thr Ala Glu Glu Val
            1140                1145                1150        
Pro Glu Asp Pro Leu Leu Lys Ala Lys Arg Arg Arg Val Ser Lys Gly
        1155                1160                1165            
Leu His Pro Lys Lys Gln Arg His Leu Leu His Leu Arg Glu Arg Trp
    1170                1175                1180                
Glu Gln Gln Val Ser Ala Ala Asp Gly Lys Pro Gly Arg Gln Ser Arg
1185                1190                1195                1200
Lys Glu Val Thr Gln Ala Thr Gln Pro Glu Ala Ile Pro Gln Gly Thr
                1205                1210                1215    
Asn Ile Thr Glu Glu Lys Pro Gly Arg Lys Arg Ala Glu Ala Lys Gly
            1220                1225                1230        
Asn Arg Ser Trp Ser Glu Glu Ser Leu Lys Pro Ser Asp Asn Glu Gln
        1235                1240                1245            
Gly Leu Pro Val Phe Ser Gly Ser Pro Pro Met Lys Ser Leu Ser Ser
    1250                1255                1260                
Thr Ser Ala Gly Gly Lys Lys Gln Ala Gln Pro Ser Cys Ala Pro Ala
1265                1270                1275                1280
Ser Arg Pro Pro Ala Lys Gln Gln Lys Ile Lys Glu Asn Gln Lys Thr
                1285                1290                1295    
Asp Val Leu Cys Ala Asp Glu Glu Glu Asp Cys Gln Ala Ala Ser Leu
            1300                1305                1310        
Leu Gln Lys Tyr Thr Asp Asn Ser Glu Lys Pro Ser Gly Lys Arg Leu
        1315                1320                1325            
Cys Lys Thr Lys His Leu Ile Pro Gln Glu Ser Arg Arg Gly Leu Pro
    1330                1335                1340                
Leu Thr Gly Glu Tyr Tyr Val Glu Asn Ala Asp Gly Lys Val Thr Val
1345                1350                1355                1360
Arg Arg Phe Arg Lys Arg Pro Glu Pro Ser Ser Asp Tyr Asp Leu Ser
                1365                1370                1375    
Pro Ala Lys Gln Glu Pro Lys Pro Phe Asp Arg Leu Gln Gln Leu Leu
            1380                1385                1390        
Pro Ala Ser Gln Ser Thr Gln Leu Pro Cys Ser Ser Ser Pro Gln Glu
        1395                1400                1405            
Thr Thr Gln Ser Arg Pro Met Pro Pro Glu Ala Arg Arg Leu Ile Val
    1410                1415                1420                
Asn Lys Asn Ala Gly Glu Thr Leu Leu Gln Arg Ala Ala Arg Leu Gly
1425                1430                1435                1440
Tyr Glu Glu Val Val Leu Tyr Cys Leu Glu Asn Lys Ile Cys Asp Val
                1445                1450                1455    
Asn His Arg Asp Asn Ala Gly Tyr Cys Ala Leu His Glu Ala Cys Ala
            1460                1465                1470        
Arg Gly Trp Leu Asn Ile Val Arg His Leu Leu Glu Tyr Gly Ala Asp
        1475                1480                1485            
Val Asn Cys Ser Ala Gln Asp Gly Thr Arg Pro Leu His Asp Ala Val
    1490                1495                1500                
Glu Asn Asp His Leu Glu Ile Val Arg Leu Leu Leu Ser Tyr Gly Ala
1505                1510                1515                1520
Asp Pro Thr Leu Ala Thr Tyr Ser Gly Arg Thr Ile Met Lys Met Thr
                1525                1530                1535    
His Ser Glu Leu Met Glu Lys Phe Leu Thr Asp Tyr Leu Asn Asp Leu
            1540                1545                1550        
Gln Gly Arg Asn Asp Asp Asp Ala Ser Gly Thr Trp Asp Phe Tyr Gly
        1555                1560                1565            
Ser Ser Val Cys Glu Pro Asp Asp Glu Ser Gly Tyr Asp Val Leu Ala
    1570                1575                1580                
Asn Pro Pro Gly Pro Glu Asp Gln Asp Asp Asp Asp Asp Ala Tyr Ser
1585                1590                1595                1600
Asp Val Phe Glu Phe Glu Phe Ser Glu Thr Pro Leu Leu Pro Cys Tyr
                1605                1610                1615    
Asn Ile Gln Val Ser Val Ala Gln Gly Pro Arg Asn Trp Leu Leu Leu
            1620                1625                1630        
Ser Asp Val Leu Lys Lys Leu Lys Met Ser Ser Arg Ile Phe Arg Cys
        1635                1640                1645            
Asn Phe Pro Asn Val Glu Ile Val Thr Ile Ala Glu Ala Glu Phe Tyr
    1650                1655                1660                
Arg Gln Val Ser Ala Ser Leu Leu Phe Ser Cys Ser Lys Asp Leu Glu
1665                1670                1675                1680
Ala Phe Asn Pro Glu Ser Lys Glu Leu Leu Asp Leu Val Glu Phe Thr
                1685                1690                1695    
Asn Glu Ile Gln Thr Leu Leu Gly Ser Ser Val Glu Trp Leu His Pro
            1700                1705                1710        
Ser Asp Leu Ala Ser Asp Asn Tyr Trp
        1715                1720    


<210> 8346
<211> 1011
<212> PRT
<213> Homo sapiens

<400> 8346
Met Glu Thr Ser Ser Met Leu Ser Ser Leu Asn Asp Glu Cys Lys Ser
 1               5                  10                  15      
Asp Asn Tyr Ile Glu Pro His Tyr Lys Glu Trp Tyr Arg Val Ala Ile
            20                  25                  30          
Asp Ile Leu Ile Glu His Gly Leu Glu Ala Tyr Gln Glu Phe Leu Val
        35                  40                  45              
Gln Glu Arg Val Ser Asp Phe Leu Ala Glu Glu Glu Ile Asn Tyr Ile
    50                  55                  60                  
Leu Lys Asn Val Gln Lys Val Ala Gln Ser Thr Ala His Gly Thr Asp
65                  70                  75                  80  
Asp Ser Cys Asp Asp Thr Leu Ser Ser Gly Thr Tyr Trp Pro Val Glu
                85                  90                  95      
Ser Asp Val Glu Ala Pro Asn Leu Asp Leu Gly Trp Pro Tyr Val Met
            100                 105                 110         
Pro Gly Leu Leu Gly Gly Thr His Ile Asp Leu Leu Phe His Pro Pro
        115                 120                 125             
Arg Ala His Leu Leu Thr Ile Lys Glu Thr Ile Arg Lys Met Ile Lys
    130                 135                 140                 
Glu Ala Arg Lys Val Ile Ala Leu Val Met Asp Ile Phe Thr Asp Val
145                 150                 155                 160 
Asp Ile Phe Lys Glu Ile Val Glu Ala Ser Thr Arg Gly Val Ser Val
                165                 170                 175     
Tyr Ile Leu Leu Asp Glu Ser Asn Phe Asn His Phe Leu Asn Met Thr
            180                 185                 190         
Glu Lys Gln Gly Cys Ser Val Gln Arg Leu Arg Asn Ile Arg Val Arg
        195                 200                 205             
Thr Val Lys Gly Gln Asp Tyr Leu Ser Lys Thr Gly Ala Lys Phe His
    210                 215                 220                 
Gly Lys Met Glu Gln Lys Phe Leu Leu Val Asp Cys Gln Lys Val Met
225                 230                 235                 240 
Tyr Gly Ser Tyr Ser Tyr Met Trp Ser Phe Glu Lys Ala His Leu Ser
                245                 250                 255     
Met Val Gln Ile Ile Thr Gly Gln Leu Val Glu Ser Phe Asp Glu Glu
            260                 265                 270         
Phe Arg Thr Leu Tyr Ala Arg Ser Cys Val Pro Ser Ser Phe Ala Gln
        275                 280                 285             
Glu Glu Ser Ala Arg Val Lys His Gly Lys Ala Leu Trp Glu Asn Gly
    290                 295                 300                 
Thr Tyr Gln His Ser Val Ser Ser Leu Ala Ser Val Ser Ser Gln Arg
305                 310                 315                 320 
Asn Leu Phe Gly Arg Gln Asp Lys Ile His Lys Leu Asp Ser Ser Tyr
                325                 330                 335     
Phe Lys Asn Arg Gly Ile Tyr Thr Leu Asn Glu His Asp Lys Tyr Asn
            340                 345                 350         
Ile Arg Ser His Gly Tyr Lys Pro His Phe Val Pro Asn Phe Asn Gly
        355                 360                 365             
Pro Asn Ala Ile Arg Gln Phe Gln Pro Asn Gln Ile Asn Glu Asn Trp
    370                 375                 380                 
Lys Arg His Ser Tyr Ala Gly Glu Gln Pro Glu Thr Val Pro Tyr Leu
385                 390                 395                 400 
Leu Leu Asn Arg Ala Leu Asn Arg Thr Asn Asn Pro Pro Gly Asn Trp
                405                 410                 415     
Lys Lys Pro Ser Asp Ser Leu Ser Val Ala Ser Ser Ser Arg Glu Gly
            420                 425                 430         
Tyr Val Ser His His Asn Thr Pro Ala Gln Ser Phe Ala Asn Arg Leu
        435                 440                 445             
Ala Gln Arg Lys Thr Thr Asn Leu Ala Asp Arg Asn Ser Asn Val Arg
    450                 455                 460                 
Arg Ser Phe Asn Gly Thr Asp Asn His Ile Arg Phe Leu Gln Gln Arg
465                 470                 475                 480 
Met Pro Thr Leu Glu His Thr Thr Lys Ser Phe Leu Arg Asn Trp Arg
                485                 490                 495     
Ile Glu Ser Tyr Leu Asn Asp His Ser Glu Ala Thr Pro Asp Ser Asn
            500                 505                 510         
Gly Ser Ala Leu Gly Asp Arg Phe Glu Gly Tyr Asp Asn Pro Glu Asn
        515                 520                 525             
Leu Lys Ala Asn Ala Leu Tyr Thr His Ser Arg Leu Arg Ser Ser Leu
    530                 535                 540                 
Val Phe Lys Pro Thr Leu Pro Glu Gln Lys Glu Val Asn Ser Cys Thr
545                 550                 555                 560 
Thr Gly Ser Ser Asn Ser Thr Ile Ile Gly Ser Gln Gly Ser Glu Thr
                565                 570                 575     
Pro Lys Glu Val Pro Asp Thr Pro Thr Asn Val Gln His Leu Thr Asp
            580                 585                 590         
Lys Pro Leu Pro Glu Ser Ile Pro Lys Leu Pro Leu Gln Ser Glu Ala
        595                 600                 605             
Pro Lys Met His Thr Leu Gln Val Pro Glu Asn His Ser Val Ala Leu
    610                 615                 620                 
Asn Gln Thr Thr Asn Gly His Thr Glu Ser Asn Asn Tyr Ile Tyr Lys
625                 630                 635                 640 
Thr Leu Gly Val Asn Lys Gln Thr Glu Asn Leu Lys Asn Gln Gln Thr
                645                 650                 655     
Glu Asn Leu Leu Lys Arg Arg Ser Phe Pro Leu Phe Asp Asn Ser Lys
            660                 665                 670         
Ala Asn Leu Asp Pro Gly Asn Ser Lys His Tyr Val Tyr Ser Thr Leu
        675                 680                 685             
Thr Arg Asn Arg Val Arg Gln Pro Glu Lys Pro Lys Glu Asp Leu Leu
    690                 695                 700                 
Lys Ser Ser Lys Ser Met His Asn Val Thr His Asn Leu Glu Glu Asp
705                 710                 715                 720 
Glu Glu Glu Val Thr Lys Arg Asn Ser Pro Ser Gly Thr Thr Thr Lys
                725                 730                 735     
Ser Val Ser Ile Ala Ala Leu Leu Asp Val Asn Lys Glu Glu Ser Asn
            740                 745                 750         
Lys Glu Leu Ala Ser Lys Lys Glu Val Lys Gly Ser Pro Ser Phe Leu
        755                 760                 765             
Lys Lys Gly Ser Gln Lys Leu Arg Ser Leu Leu Ser Leu Thr Pro Asp
    770                 775                 780                 
Lys Lys Glu Asn Leu Ser Lys Asn Lys Ala Pro Ala Phe Tyr Arg Leu
785                 790                 795                 800 
Cys Ser Ser Ser Asp Thr Leu Val Ser Glu Gly Glu Glu Asn Gln Lys
                805                 810                 815     
Pro Lys Lys Ser Asp Thr Lys Val Asp Ser Ser Pro Arg Arg Lys His
            820                 825                 830         
Ser Ser Ser Ser Asn Ser Gln Gly Ser Ile His Lys Ser Lys Glu Asp
        835                 840                 845             
Val Thr Val Ser Pro Ser Gln Glu Ile Asn Ala Pro Pro Asp Glu Asn
    850                 855                 860                 
Lys Arg Thr Pro Ser Pro Gly Pro Val Glu Ser Lys Phe Leu Glu Arg
865                 870                 875                 880 
Ala Gly Asp Ala Ser Ala Pro Arg Phe Asn Thr Glu Gln Ile Gln Tyr
                885                 890                 895     
Arg Asp Ser Arg Glu Ile Asn Ala Val Val Thr Pro Glu Arg Arg Pro
            900                 905                 910         
Thr Ser Ser Pro Arg Pro Thr Ser Ser Glu Leu Leu Arg Ser His Ser
        915                 920                 925             
Thr Asp Arg Arg Val Tyr Ser Arg Phe Glu Pro Phe Cys Lys Ile Glu
    930                 935                 940                 
Ser Ser Ile Gln Pro Thr Ser Asn Met Pro Asn Thr Ser Ile Asn Arg
945                 950                 955                 960 
Pro Glu Ile Lys Ser Ala Thr Met Gly Asn Ser Tyr Gly Arg Ser Ser
                965                 970                 975     
Pro Leu Leu Asn Tyr Asn Thr Gly Val Tyr Arg Ser Tyr Gln Pro Asn
            980                 985                 990         
Glu Asn Lys Phe Arg Gly Phe Met Gln Lys Phe Gly Asn Phe Ile His
        995                 1000                1005            
Lys Asn Lys
    1010    


<210> 8347
<211> 2157
<212> PRT
<213> Homo sapiens

<400> 8347
Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys
 1               5                  10                  15      
Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu
            20                  25                  30          
Ile Gln Lys Pro Ala Val Ala Pro Arg His Gly Leu Gln Ser Leu Gly
        35                  40                  45              
Lys Val Ala Ile Ala Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser
    50                  55                  60                  
Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro
65                  70                  75                  80  
Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys
                85                  90                  95      
Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Glu Ser Gln Pro Leu Pro
            100                 105                 110         
Ala Ser Gln Thr Pro Ala Ser Asn Gln Pro Lys Arg Pro Pro Ala Ala
        115                 120                 125             
Pro Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln
    130                 135                 140                 
Ala Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser
145                 150                 155                 160 
Leu Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala
                165                 170                 175     
Gly Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser
            180                 185                 190         
Ser Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg
        195                 200                 205             
Asp Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys
    210                 215                 220                 
Leu His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro
225                 230                 235                 240 
Pro Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro
                245                 250                 255     
Pro Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg
            260                 265                 270         
Tyr Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro
        275                 280                 285             
Arg Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro
    290                 295                 300                 
Ser Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln
305                 310                 315                 320 
Glu Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr
                325                 330                 335     
Glu Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu
            340                 345                 350         
Glu Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu
        355                 360                 365             
Arg Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu
    370                 375                 380                 
Pro Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu
385                 390                 395                 400 
Thr Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Pro His
                405                 410                 415     
Arg Gly Pro Ala Gly Asn Trp Gly Pro Pro Gly Asp Tyr Pro Asp Arg
            420                 425                 430         
Gly Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp Glu Asp Glu Ala
        435                 440                 445             
Trp Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile Ser Leu Ala Val
    450                 455                 460                 
Glu Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg Arg Met Gln Glu
465                 470                 475                 480 
Glu Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg Leu Asp Glu Lys
                485                 490                 495     
Phe Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro Ala Ala Pro Pro
            500                 505                 510         
Ala Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val Pro Lys Glu Leu
        515                 520                 525             
Pro Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro Thr Pro Glu Lys
    530                 535                 540                 
Glu Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln Ser Thr Pro Thr
545                 550                 555                 560 
Pro Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly Gly Gly Ser Thr
                565                 570                 575     
Ser Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro Val Glu Pro Gln
            580                 585                 590         
Leu Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu Val Pro Pro Pro
        595                 600                 605             
Thr Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly Asp Gly Ile Gly
    610                 615                 620                 
Pro Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr Pro Lys Tyr Gln
625                 630                 635                 640 
Lys Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln Glu Gln Leu Leu
                645                 650                 655     
Lys Gln Gln Gln Gln His Gln Trp Gln Gln His Gln Gln Gly Ser Ala
            660                 665                 670         
Pro Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro Val Thr Leu Gly
        675                 680                 685             
Ala Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro Lys Ala Leu Tyr
    690                 695                 700                 
Pro Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro Met Asn Phe Asp
705                 710                 715                 720 
Pro Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro Arg Leu Leu Gln
                725                 730                 735     
Gly Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val His Pro Ser Gly
            740                 745                 750         
Leu Val Pro Arg Glu Arg Ser Asp Ser Gly Gly Ser Ser Ser Glu Pro
        755                 760                 765             
Phe Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg Gly Thr Pro Pro
    770                 775                 780                 
Val Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe Thr Ala Thr Pro
785                 790                 795                 800 
Ala Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln Ala Ala Asp Glu
                805                 810                 815     
Asp Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val Pro Pro Pro Pro
            820                 825                 830         
Pro Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn Gly Ala Pro Gly
        835                 840                 845             
Pro Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly Pro Arg Pro Leu
    850                 855                 860                 
Pro Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile Gln Thr Pro Pro
865                 870                 875                 880 
Pro Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln Leu Thr Gly Pro
                885                 890                 895     
Glu Ala Gly Arg Lys Pro Ala Arg Gly Val Gly Ser Gly Gly Gln Gly
            900                 905                 910         
Pro Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr Arg Trp Gly Pro
        915                 920                 925             
Arg Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu Glu Pro Gly Ala
    930                 935                 940                 
Pro Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro Pro Pro Thr Lys
945                 950                 955                 960 
Val Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly Asp Glu Thr Pro
                965                 970                 975     
Lys Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys Gly Lys Leu Gly
            980                 985                 990         
Gly Pro Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser Pro Ala Pro Arg
        995                 1000                1005            
Leu Arg Arg Asp Tyr Ser Tyr Glu Arg Val Gly Pro Thr Ser Cys Arg
    1010                1015                1020                
Gly Arg Gly Arg Gly Glu Tyr Phe Ala Arg Gly Arg Gly Phe Arg Gly
1025                1030                1035                1040
Thr Tyr Gly Gly Arg Gly Arg Gly Ala Arg Ser Arg Glu Phe Arg Ser
                1045                1050                1055    
Tyr Arg Glu Phe Arg Gly Asp Asp Gly Arg Gly Gly Gly Thr Gly Gly
            1060                1065                1070        
Pro Asn His Pro Pro Ala Pro Arg Gly Arg Thr Ala Ser Glu Thr Arg
        1075                1080                1085            
Ser Glu Gly Ser Glu Tyr Glu Glu Ile Pro Lys Arg Arg Arg Gln Arg
    1090                1095                1100                
Gly Ser Glu Thr Gly Ser Glu Thr His Glu Ser Asp Leu Ala Pro Ser
1105                1110                1115                1120
Asp Lys Glu Ala Pro Thr Pro Lys Glu Gly Thr Leu Thr Gln Val Pro
                1125                1130                1135    
Leu Ala Pro Pro Pro Pro Gly Ala Pro Pro Ser Pro Ala Pro Ala Arg
            1140                1145                1150        
Phe Thr Ala Arg Gly Gly Arg Val Phe Thr Pro Arg Gly Val Pro Ser
        1155                1160                1165            
Arg Arg Gly Arg Gly Gly Gly Arg Pro Pro Pro Gln Val Cys Pro Gly
    1170                1175                1180                
Trp Ser Pro Pro Ala Lys Ser Leu Ala Pro Lys Lys Pro Pro Thr Gly
1185                1190                1195                1200
Pro Leu Pro Pro Ser Lys Glu Pro Leu Lys Glu Lys Leu Ile Pro Gly
                1205                1210                1215    
Pro Leu Ser Pro Val Ala Arg Gly Gly Ser Asn Gly Gly Ser Asn Val
            1220                1225                1230        
Gly Met Glu Asp Gly Glu Arg Pro Arg Arg Arg Arg His Gly Arg Ala
        1235                1240                1245            
Gln Gln Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu Lys Gln Glu Arg
    1250                1255                1260                
Glu Asn Ala Ala Arg Gly Ser Glu Gly Lys Pro Ser Leu Thr Leu Pro
1265                1270                1275                1280
Ala Ser Ala Pro Ala Pro Glu Glu Ala Leu Thr Thr Val Thr Val Ala
                1285                1290                1295    
Pro Ala Pro Arg Arg Ala Ala Ala Lys Ser Pro Asp Leu Ser Asn Gln
            1300                1305                1310        
Asn Ser Asp Gln Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu Ser Ser
        1315                1320                1325            
Asp Phe Thr Ser Glu Arg Arg Gly Asp Lys Glu Ala Pro Pro Pro Val
    1330                1335                1340                
Leu Leu Thr Pro Lys Ala Val Gly Thr Pro Gly Gly Gly Gly Gly Gly
1345                1350                1355                1360
Ala Val Pro Gly Ile Ser Ala Met Ser Arg Gly Asp Leu Ser Gln Arg
                1365                1370                1375    
Ala Lys Asp Leu Ser Lys Arg Ser Phe Ser Ser Gln Arg Pro Gly Met
            1380                1385                1390        
Glu Arg Gln Asn Arg Arg Pro Gly Pro Gly Gly Lys Ala Gly Ser Ser
        1395                1400                1405            
Gly Ser Ser Ser Gly Gly Gly Gly Gly Gly Pro Gly Gly Arg Thr Gly
    1410                1415                1420                
Pro Gly Arg Gly Asp Lys Arg Ser Trp Pro Ser Pro Lys Asn Arg Ser
1425                1430                1435                1440
Arg Pro Pro Glu Glu Arg Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro
                1445                1450                1455    
Pro Ser Ser Ser Ala Val Phe Arg Leu Asp Gln Val Ile His Ser Asn
            1460                1465                1470        
Pro Ala Gly Ile Gln Gln Ala Leu Ala Gln Leu Ser Ser Arg Gln Gly
        1475                1480                1485            
Ser Val Thr Ala Pro Gly Gly His Pro Arg His Lys Pro Gly Pro Pro
    1490                1495                1500                
Gln Ala Pro Gln Gly Pro Ser Pro Arg Pro Pro Thr Arg Tyr Glu Pro
1505                1510                1515                1520
Gln Arg Val Asn Ser Gly Leu Ser Ser Asp Pro His Phe Glu Glu Pro
                1525                1530                1535    
Gly Pro Met Val Arg Gly Val Gly Gly Thr Pro Arg Asp Ser Ala Gly
            1540                1545                1550        
Val Ser Pro Phe Pro Pro Lys Arg Arg Glu Arg Pro Pro Arg Lys Pro
        1555                1560                1565            
Glu Leu Leu Gln Glu Glu Ser Leu Pro Pro Pro His Ser Ser Gly Phe
    1570                1575                1580                
Leu Gly Ser Lys Pro Glu Gly Pro Gly Pro Gln Ala Glu Ser Arg Asp
1585                1590                1595                1600
Thr Gly Thr Glu Ala Leu Thr Pro His Ile Trp Asn Arg Leu His Thr
                1605                1610                1615    
Ala Thr Ser Arg Lys Ser Tyr Arg Pro Ser Ser Met Glu Pro Trp Met
            1620                1625                1630        
Glu Pro Leu Ser Pro Phe Glu Asp Val Ala Gly Thr Glu Met Ser Gln
        1635                1640                1645            
Ser Asp Ser Gly Val Asp Leu Ser Gly Asp Ser Gln Val Ser Ser Gly
    1650                1655                1660                
Pro Cys Ser Gln Arg Ser Ser Pro Asp Gly Gly Leu Lys Gly Ala Ala
1665                1670                1675                1680
Glu Gly Pro Pro Lys Arg Pro Gly Gly Ser Ser Pro Leu Asn Ala Val
                1685                1690                1695    
Pro Cys Glu Gly Pro Pro Gly Ser Glu Pro Pro Arg Arg Pro Pro Pro
            1700                1705                1710        
Ala Pro His Asp Gly Asp Arg Lys Glu Leu Pro Arg Glu Gln Pro Leu
        1715                1720                1725            
Pro Pro Gly Pro Ile Gly Thr Glu Arg Ser Gln His Thr Asp Arg Gly
    1730                1735                1740                
Thr Glu Pro Gly Pro Ile Arg Pro Ser His Arg Pro Gly Pro Pro Val
1745                1750                1755                1760
Gln Phe Gly Thr Ser Asp Lys Asp Ser Asp Leu Arg Leu Val Val Gly
                1765                1770                1775    
Asp Ser Leu Lys Ala Glu Lys Glu Leu Thr Ala Ser Val Thr Glu Ala
            1780                1785                1790        
Ile Pro Val Ser Arg Asp Trp Glu Leu Leu Pro Ser Ala Ala Ala Ser
        1795                1800                1805            
Ala Glu Pro Gln Ser Lys Asn Leu Asp Ser Gly His Cys Val Pro Glu
    1810                1815                1820                
Pro Ser Ser Ser Gly Gln Arg Leu Tyr Pro Glu Val Phe Tyr Gly Ser
1825                1830                1835                1840
Ala Gly Pro Ser Ser Ser Gln Ile Ser Gly Gly Ala Met Asp Ser Gln
                1845                1850                1855    
Leu His Pro Asn Ser Gly Gly Phe Arg Pro Gly Thr Pro Ser Leu His
            1860                1865                1870        
Pro Tyr Arg Ser Gln Pro Leu Tyr Leu Pro Pro Gly Pro Ala Pro Pro
        1875                1880                1885            
Ser Ala Leu Leu Ser Gly Val Ala Leu Lys Gly Gln Phe Leu Asp Phe
    1890                1895                1900                
Ser Thr Met Gln Ala Thr Glu Leu Gly Lys Leu Pro Ala Gly Gly Val
1905                1910                1915                1920
Leu Tyr Pro Pro Pro Ser Phe Leu Tyr Ser Pro Ala Phe Cys Pro Ser
                1925                1930                1935    
Pro Leu Pro Asp Thr Ser Leu Leu Gln Val Arg Gln Asp Leu Pro Ser
            1940                1945                1950        
Pro Ser Asp Phe Tyr Ser Thr Pro Leu Gln Pro Gly Gly Gln Ser Gly
        1955                1960                1965            
Phe Leu Pro Ser Gly Ala Pro Ala Gln Gln Met Leu Leu Pro Met Val
    1970                1975                1980                
Asp Ser Gln Leu Pro Val Val Asn Phe Gly Ser Leu Pro Pro Ala Pro
1985                1990                1995                2000
Pro Pro Ala Pro Pro Pro Leu Ser Leu Leu Pro Val Gly Pro Ala Leu
                2005                2010                2015    
Gln Pro Pro Ser Leu Ala Val Arg Pro Pro Pro Ala Pro Ala Thr Arg
            2020                2025                2030        
Val Leu Pro Ser Pro Ala Arg Pro Phe Pro Ala Ser Leu Gly Arg Ala
        2035                2040                2045            
Glu Leu His Pro Val Glu Leu Lys Pro Phe Gln Asp Tyr Gln Lys Leu
    2050                2055                2060                
Ser Ser Asn Leu Gly Gly Pro Gly Ser Ser Arg Thr Pro Pro Thr Gly
2065                2070                2075                2080
Arg Ser Phe Ser Gly Leu Asn Ser Arg Leu Lys Ala Thr Pro Ser Thr
                2085                2090                2095    
Tyr Ser Gly Val Phe Arg Thr Gln Arg Val Asp Leu Tyr Gln Gln Ala
            2100                2105                2110        
Ser Pro Pro Asp Ala Leu Arg Trp Ile Pro Lys Pro Trp Glu Arg Thr
        2115                2120                2125            
Gly Leu Pro Pro Arg Glu Gly Pro Ser Arg Arg Ala Glu Glu Pro Gly
    2130                2135                2140                
Ser Arg Gly Asp Lys Glu Pro Gly Leu Pro Pro Pro Arg
2145                2150                2155        


<210> 8348
<211> 2142
<212> PRT
<213> Homo sapiens

<400> 8348
Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys
 1               5                  10                  15      
Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu
            20                  25                  30          
Ile Gln Lys Pro Ala Cys Cys Pro Ser Pro Trp Pro Ala Glu Ser Arg
        35                  40                  45              
Glu Ser Cys His Cys Pro Ala Tyr Arg Pro Pro Ala Asn Leu Pro Ser
    50                  55                  60                  
Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro
65                  70                  75                  80  
Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys
                85                  90                  95      
Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Glu Ser Gln Pro Leu Pro
            100                 105                 110         
Ala Ser Gln Thr Pro Ala Ser Asn Gln Pro Lys Arg Pro Pro Ala Ala
        115                 120                 125             
Pro Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln
    130                 135                 140                 
Ala Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser
145                 150                 155                 160 
Leu Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala
                165                 170                 175     
Gly Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser
            180                 185                 190         
Ser Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg
        195                 200                 205             
Asp Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys
    210                 215                 220                 
Leu His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro
225                 230                 235                 240 
Pro Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro
                245                 250                 255     
Pro Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg
            260                 265                 270         
Tyr Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro
        275                 280                 285             
Arg Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro
    290                 295                 300                 
Ser Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln
305                 310                 315                 320 
Glu Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr
                325                 330                 335     
Glu Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu
            340                 345                 350         
Glu Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu
        355                 360                 365             
Arg Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu
    370                 375                 380                 
Pro Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu
385                 390                 395                 400 
Thr Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Gly Asp
                405                 410                 415     
Tyr Pro Asp Arg Gly Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp
            420                 425                 430         
Glu Asp Glu Ala Trp Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile
        435                 440                 445             
Ser Leu Ala Val Glu Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg
    450                 455                 460                 
Arg Met Gln Glu Glu Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg
465                 470                 475                 480 
Leu Asp Glu Lys Phe Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro
                485                 490                 495     
Ala Ala Pro Pro Ala Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val
            500                 505                 510         
Pro Lys Glu Leu Pro Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro
        515                 520                 525             
Thr Pro Glu Thr Glu Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln
    530                 535                 540                 
Ser Thr Pro Thr Pro Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly
545                 550                 555                 560 
Gly Gly Ser Thr Ser Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro
                565                 570                 575     
Val Glu Pro Gln Leu Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu
            580                 585                 590         
Val Pro Pro Pro Thr Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly
        595                 600                 605             
Asp Gly Ile Gly Pro Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr
    610                 615                 620                 
Pro Lys Tyr Gln Lys Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln
625                 630                 635                 640 
Glu Gln Leu Leu Lys Gln Gln Gln Gln His Gln Trp Gln Gln His Gln
                645                 650                 655     
Gln Gly Ser Ala Pro Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro
            660                 665                 670         
Val Thr Leu Gly Ala Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro
        675                 680                 685             
Lys Ala Leu Tyr Pro Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro
    690                 695                 700                 
Met Asn Phe Asp Pro Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro
705                 710                 715                 720 
Arg Leu Leu Gln Gly Arg Pro Pro Leu Glu Phe Tyr Pro Pro Gly Val
                725                 730                 735     
His Pro Ser Gly Leu Val Pro Arg Glu Arg Ser Asp Ser Leu Gly Leu
            740                 745                 750         
Ser Ser Glu Pro Phe Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg
        755                 760                 765             
Gly Thr Pro Pro Val Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe
    770                 775                 780                 
Thr Ala Thr Pro Ala Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln
785                 790                 795                 800 
Ala Ala Asp Glu Asp Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val
                805                 810                 815     
Pro Pro Pro Pro Pro Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn
            820                 825                 830         
Gly Ala Pro Gly Pro Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly
        835                 840                 845             
Pro Arg Pro Leu Pro Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile
    850                 855                 860                 
Gln Thr Pro Pro Pro Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln
865                 870                 875                 880 
Leu Thr Gly Pro Glu Ala Gly Arg Lys Leu Pro Ala Ser Arg Ser Gly
                885                 890                 895     
Ala Gly Pro Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr Arg Trp
            900                 905                 910         
Gly Pro Arg Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu Glu Pro
        915                 920                 925             
Gly Ala Pro Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro Pro Pro
    930                 935                 940                 
Thr Lys Val Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly Asp Glu
945                 950                 955                 960 
Thr Pro Lys Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys Gly Lys
                965                 970                 975     
Leu Gly Gly Pro Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser Pro Ala
            980                 985                 990         
Pro Arg Leu Arg Arg Asp Tyr Ser Tyr Glu Arg Val Gly Pro Thr Ser
        995                 1000                1005            
Cys Arg Gly Arg Gly Arg Gly Glu Tyr Phe Ala Arg Gly Arg Gly Phe
    1010                1015                1020                
Arg Gly Thr Tyr Gly Gly Arg Gly Arg Gly Gly Gln Ala Asn Ser Ala
1025                1030                1035                1040
Val Thr Glu Ser Phe Glu Glu Met Met Gly Val Glu Val Gly Gln Gly
                1045                1050                1055    
Asp Gln Thr Thr Leu Leu Leu Pro Glu Ala Ala Met Pro Ala Arg His
            1060                1065                1070        
Gly Ala Arg Val Gln Ser Met Arg Lys Ser Pro Ser Gly Ala Gly Ser
        1075                1080                1085            
Gly Ala Gln Lys Gln Ala Ala Arg Pro Met Arg Val Ile Trp Leu Leu
    1090                1095                1100                
Gln Thr Arg Arg Leu Pro His Pro Arg Arg Glu His Ser Pro Arg Ser
1105                1110                1115                1120
Ser Arg Ser Pro Thr Thr Arg Ser Pro Thr Leu His Arg Ala Pro Ala
                1125                1130                1135    
Arg Phe Thr Cys Pro Gly Val Gly Glu Ser Ser Leu Pro Glu Gly Ala
            1140                1145                1150        
Ile Ser Pro Gly Pro Arg Arg Arg Glu Ala Pro Pro Gln Val Cys Pro
        1155                1160                1165            
Gly Trp Ser Pro Pro Ala Lys Ser Leu Ala Pro Lys Lys Pro Pro Thr
    1170                1175                1180                
Gly Pro Leu Pro Pro Ser Lys Glu Pro Leu Lys Glu Lys Leu Ile Pro
1185                1190                1195                1200
Gly Pro Leu Ser Pro Val Ala Arg Gly Gly Ser Asn Gly Gly Ser Asn
                1205                1210                1215    
Val Gly Met Glu Asp Gly Glu Arg Pro Arg Arg Arg Arg His Gly Arg
            1220                1225                1230        
Ala Gln Gln Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu Lys Gln Glu
        1235                1240                1245            
Arg Glu Asn Ala Ala Arg Gly Ser Glu Gly Lys Pro Ser Leu Thr Leu
    1250                1255                1260                
Pro Ala Ser Ala Pro Gly Pro Glu Glu Ala Leu Thr Thr Val Thr Val
1265                1270                1275                1280
Ala Pro Ala Pro Pro Arg Ala Ala Ala Lys Ser Pro Asp Leu Ser Asn
                1285                1290                1295    
Gln Asn Ser Asp Gln Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu Ser
            1300                1305                1310        
Ser Asp Phe Thr Ser Glu Arg Arg Gly Asp Lys Glu Ala Pro Pro Pro
        1315                1320                1325            
Val Leu Leu Thr Pro Lys Ala Val Gly Thr Pro Gly Gly Gly Gly Gly
    1330                1335                1340                
Gly Ala Val Pro Gly Ile Ser Ala Met Ser Arg Gly Asp Leu Ser Gln
1345                1350                1355                1360
Arg Ala Lys Asp Leu Ser Lys Arg Ser Phe Ser Ser Gln Arg Pro Gly
                1365                1370                1375    
Met Glu Arg Gln Asn Arg Arg Pro Gly Pro Gly Gly Lys Ala Gly Ser
            1380                1385                1390        
Ser Gly Ser Ser Ser Gly Gly Gly Gly Gly Gly Pro Gly Gly Arg Thr
        1395                1400                1405            
Gly Pro Gly Arg Gly Asp Lys Arg Ser Trp Pro Ser Pro Lys Asn Arg
    1410                1415                1420                
Ser Arg Pro Pro Glu Glu Arg Pro Pro Gly Leu Pro Leu Pro Pro Pro
1425                1430                1435                1440
Pro Pro Ser Ser Ser Ala Val Phe Arg Leu Asp Gln Val Ile His Ser
                1445                1450                1455    
Asn Pro Ala Gly Ile Gln Gln Ala Leu Ala Gln Leu Ser Ser Arg Gln
            1460                1465                1470        
Gly Ser Val Thr Ala Pro Gly Gly His Pro Arg His Lys Pro Gly Pro
        1475                1480                1485            
Pro Gln Ala Pro Gln Gly Pro Ser Pro Arg Pro Pro Thr Arg Tyr Glu
    1490                1495                1500                
Pro Gln Arg Val Asn Ser Gly Leu Ser Ser Asp Pro His Phe Glu Glu
1505                1510                1515                1520
Pro Gly Pro Met Val Arg Gly Val Gly Gly Thr Pro Arg Asp Ser Ala
                1525                1530                1535    
Gly Val Ser Pro Phe Pro Pro Lys Arg Arg Glu Arg Pro Pro Arg Lys
            1540                1545                1550        
Pro Glu Leu Leu Gln Glu Glu Ser Leu Pro Pro Pro His Ser Ser Gly
        1555                1560                1565            
Phe Leu Gly Ser Lys Pro Glu Gly Pro Gly Pro Gln Ala Glu Ser Arg
    1570                1575                1580                
Asp Thr Gly Thr Glu Ala Leu Thr Pro His Ile Trp Asn Arg Leu His
1585                1590                1595                1600
Thr Ala Thr Ser Arg Lys Ser Tyr Arg Pro Thr Ser Met Glu Pro Trp
                1605                1610                1615    
Met Glu Pro Leu Ser Pro Phe Glu Asp Val Ala Gly Thr Glu Met Ser
            1620                1625                1630        
Gln Ser Asp Ser Gly Val Asp Leu Ser Gly Asp Ser Gln Val Ser Ser
        1635                1640                1645            
Gly Pro Cys Ser Gln Arg Ser Ser Pro Asp Gly Gly Leu Lys Gly Ala
    1650                1655                1660                
Ala Glu Gly Pro Pro Lys Arg Pro Gly Gly Ser Ser Pro Leu Asn Ala
1665                1670                1675                1680
Val Pro Cys Glu Gly Pro Pro Gly Ser Glu Pro Pro Arg Arg Pro Pro
                1685                1690                1695    
Pro Ala Pro His Asp Gly Asp Arg Lys Glu Leu Pro Arg Glu Gln Pro
            1700                1705                1710        
Leu Pro Pro Gly Pro Ile Gly Thr Glu Arg Ser Gln Arg Thr Asp Arg
        1715                1720                1725            
Gly Thr Glu Pro Gly Pro Ile Arg Pro Ser His Arg Pro Gly Pro Pro
    1730                1735                1740                
Val Gln Phe Gly Thr Ser Asp Lys Asp Ser Asp Leu Arg Leu Val Val
1745                1750                1755                1760
Gly Asp Ser Leu Lys Ala Glu Lys Glu Leu Thr Ala Ser Val Thr Glu
                1765                1770                1775    
Ala Ile Pro Val Ser Arg Asp Trp Glu Leu Leu Pro Ser Ala Ala Ala
            1780                1785                1790        
Ser Ala Glu Pro Gln Ser Lys Asn Leu Asp Ser Gly His Cys Val Pro
        1795                1800                1805            
Glu Pro Ser Ser Ser Gly Gln Arg Leu Tyr Pro Glu Val Phe Tyr Gly
    1810                1815                1820                
Ser Ala Gly Pro Ser Ser Ser Gln Ile Ser Gly Gly Ser His Gly Leu
1825                1830                1835                1840
Ser Ile Thr Ser Lys Gln Trp Arg Leu Arg Pro Gly Thr Pro Ser Leu
                1845                1850                1855    
His Pro Tyr Arg Ser Gln Pro Leu Tyr Leu Pro Pro Gly Pro Ala Pro
            1860                1865                1870        
Pro Ser Ala Leu Leu Ser Gly Val Ala Leu Lys Gly Gln Phe Leu Asp
        1875                1880                1885            
Phe Ser Thr Met Gln Ala Thr Glu Leu Gly Lys Leu Pro Ala Gly Gly
    1890                1895                1900                
Val Leu Tyr Pro Pro Pro Ser Phe Leu Tyr Ser Pro Ala Phe Cys Pro
1905                1910                1915                1920
Ser Pro Leu Pro Asp Thr Ser Leu Leu Gln Val Arg Gln Asp Leu Pro
                1925                1930                1935    
Ser Pro Ser Asp Phe Tyr Ser Thr Pro Leu Gln Pro Gly Gly Gln Ser
            1940                1945                1950        
Gly Phe Leu Pro Ser Gly Ala Pro Ala Gln Gln Met Leu Leu Pro Met
        1955                1960                1965            
Val Asp Ser Gln Leu Pro Val Val Asn Phe Gly Ser Leu Pro Pro Ala
    1970                1975                1980                
Pro Pro Pro Ala Pro Pro Pro Leu Ser Leu Leu Pro Val Gly Pro Ala
1985                1990                1995                2000
Leu Gln Pro Pro Ser Leu Ala Val Arg Pro Pro Pro Ala Pro Ala Thr
                2005                2010                2015    
Arg Val Leu Pro Ser Pro Ala Arg Pro Phe Pro Ala Ser Leu Gly Arg
            2020                2025                2030        
Ala Glu Leu His Pro Val Glu Leu Lys Pro Phe Gln Asp Tyr Gln Lys
        2035                2040                2045            
Leu Ser Ser Asn Leu Gly Gly Pro Gly Ser Ser Arg Thr Pro Pro Thr
    2050                2055                2060                
Gly Arg Ser Phe Ser Gly Leu Asn Ser Arg Leu Lys Ala Thr Pro Ser
2065                2070                2075                2080
Thr Tyr Ser Gly Val Phe Arg Thr Gln Arg Val Asp Leu Tyr Gln Gln
                2085                2090                2095    
Ala Ser Pro Pro Asp Ala Leu Arg Trp Ile Pro Lys Pro Trp Glu Arg
            2100                2105                2110        
Thr Gly Pro Pro Pro Arg Glu Gly Pro Ser Arg Arg Ala Glu Glu Pro
        2115                2120                2125            
Gly Ser Arg Gly Asp Lys Glu Pro Gly Leu Pro Pro Pro Arg
    2130                2135                2140        


<210> 8349
<211> 2145
<212> PRT
<213> Homo sapiens

<400> 8349
Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys
 1               5                  10                  15      
Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu
            20                  25                  30          
Ile Gln Lys Pro Ala Val Ala Pro Arg His Gly Leu Gln Ser Leu Gly
        35                  40                  45              
Lys Val Ala Ile Ala Arg Arg Met Pro Pro Pro Ala Asn Leu Pro Ser
    50                  55                  60                  
Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro
65                  70                  75                  80  
Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys
                85                  90                  95      
Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Glu Ser Gln Pro Leu Pro
            100                 105                 110         
Ala Ser Gln Thr Pro Ala Ser Asn Gln Pro Lys Arg Pro Pro Ala Ala
        115                 120                 125             
Pro Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln
    130                 135                 140                 
Ala Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser
145                 150                 155                 160 
Leu Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala
                165                 170                 175     
Gly Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser
            180                 185                 190         
Ser Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg
        195                 200                 205             
Asp Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys
    210                 215                 220                 
Leu His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro
225                 230                 235                 240 
Pro Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro
                245                 250                 255     
Pro Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg
            260                 265                 270         
Tyr Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro
        275                 280                 285             
Arg Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro
    290                 295                 300                 
Ser Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln
305                 310                 315                 320 
Glu Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr
                325                 330                 335     
Glu Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu
            340                 345                 350         
Glu Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu
        355                 360                 365             
Arg Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu
    370                 375                 380                 
Pro Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu
385                 390                 395                 400 
Thr Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Gly Asp
                405                 410                 415     
Tyr Pro Asp Arg Gly Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp
            420                 425                 430         
Glu Asp Glu Ala Trp Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile
        435                 440                 445             
Ser Leu Ala Val Glu Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg
    450                 455                 460                 
Arg Met Gln Glu Glu Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg
465                 470                 475                 480 
Leu Asp Glu Lys Phe Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro
                485                 490                 495     
Ala Ala Pro Pro Ala Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val
            500                 505                 510         
Pro Lys Glu Leu Pro Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro
        515                 520                 525             
Thr Pro Glu Lys Glu Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln
    530                 535                 540                 
Ser Thr Pro Thr Pro Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly
545                 550                 555                 560 
Gly Gly Ser Thr Ser Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro
                565                 570                 575     
Val Glu Pro Gln Leu Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu
            580                 585                 590         
Val Pro Pro Pro Thr Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly
        595                 600                 605             
Asp Gly Ile Gly Pro Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr
    610                 615                 620                 
Pro Lys Tyr Gln Lys Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln
625                 630                 635                 640 
Glu Gln Leu Leu Lys Gln Gln Gln Gln His Gln Trp Gln Gln His Gln
                645                 650                 655     
Gln Gly Ser Ala Pro Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro
            660                 665                 670         
Val Thr Leu Gly Ala Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro
        675                 680                 685             
Lys Ala Leu Tyr Pro Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro
    690                 695                 700                 
Met Asn Phe Asp Pro Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro
705                 710                 715                 720 
Arg Leu Leu Gln Gly Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val
                725                 730                 735     
His Pro Ser Gly Leu Val Pro Arg Glu Arg Ser Asp Ser Gly Gly Ser
            740                 745                 750         
Ser Ser Glu Pro Phe Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg
        755                 760                 765             
Gly Thr Pro Pro Val Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe
    770                 775                 780                 
Thr Ala Thr Pro Ala Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln
785                 790                 795                 800 
Ala Ala Asp Glu Asp Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val
                805                 810                 815     
Pro Pro Pro Pro Pro Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn
            820                 825                 830         
Gly Ala Pro Gly Pro Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly
        835                 840                 845             
Pro Arg Pro Leu Pro Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile
    850                 855                 860                 
Gln Thr Pro Pro Pro Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln
865                 870                 875                 880 
Leu Thr Gly Pro Glu Ala Gly Arg Lys Pro Ala Arg Gly Val Gly Ser
                885                 890                 895     
Gly Gly Gln Gly Pro Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr
            900                 905                 910         
Arg Trp Gly Pro Arg Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu
        915                 920                 925             
Glu Pro Gly Ala Pro Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro
    930                 935                 940                 
Pro Pro Thr Lys Val Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly
945                 950                 955                 960 
Asp Glu Thr Pro Lys Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys
                965                 970                 975     
Gly Lys Leu Gly Gly Pro Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser
            980                 985                 990         
Pro Ala Pro Arg Leu Arg Arg Asp Tyr Ser Tyr Glu Arg Val Gly Pro
        995                 1000                1005            
Thr Ser Cys Arg Gly Arg Gly Arg Gly Glu Tyr Phe Ala Arg Gly Arg
    1010                1015                1020                
Gly Phe Arg Gly Thr Tyr Gly Gly Arg Gly Arg Gly Ala Arg Ser Arg
1025                1030                1035                1040
Glu Phe Arg Ser Tyr Arg Glu Phe Arg Gly Asp Asp Gly Arg Gly Gly
                1045                1050                1055    
Gly Thr Gly Gly Pro Asn His Pro Pro Ala Pro Arg Gly Arg Thr Ala
            1060                1065                1070        
Ser Glu Thr Arg Ser Glu Gly Ser Glu Tyr Glu Glu Ile Pro Lys Arg
        1075                1080                1085            
Arg Arg Gln Arg Gly Ser Glu Thr Gly Ser Glu Thr His Glu Ser Asp
    1090                1095                1100                
Leu Ala Pro Ser Asp Lys Glu Ala Pro Thr Pro Lys Glu Gly Thr Leu
1105                1110                1115                1120
Thr Gln Val Pro Leu Ala Pro Pro Pro Pro Gly Ala Pro Pro Ser Pro
                1125                1130                1135    
Ala Pro Ala Arg Phe Thr Ala Arg Gly Gly Arg Val Phe Thr Pro Arg
            1140                1145                1150        
Gly Val Pro Ser Arg Arg Gly Arg Gly Gly Gly Arg Pro Pro Pro Gln
        1155                1160                1165            
Val Cys Pro Gly Trp Ser Pro Pro Ala Lys Ser Leu Ala Pro Lys Lys
    1170                1175                1180                
Pro Pro Thr Gly Pro Leu Pro Pro Ser Lys Glu Pro Leu Lys Glu Lys
1185                1190                1195                1200
Leu Ile Pro Gly Pro Leu Ser Pro Val Ala Arg Gly Gly Ser Asn Gly
                1205                1210                1215    
Gly Ser Asn Val Gly Met Glu Asp Gly Glu Arg Pro Arg Arg Arg Arg
            1220                1225                1230        
His Gly Arg Ala Gln Gln Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu
        1235                1240                1245            
Lys Gln Glu Arg Glu Asn Ala Ala Arg Gly Ser Glu Gly Lys Pro Ser
    1250                1255                1260                
Leu Thr Leu Pro Ala Ser Ala Pro Ala Pro Glu Glu Ala Leu Thr Thr
1265                1270                1275                1280
Val Thr Val Ala Pro Ala Pro Arg Arg Ala Ala Ala Lys Ser Pro Asp
                1285                1290                1295    
Leu Ser Asn Gln Asn Ser Asp Gln Ala Asn Glu Glu Trp Glu Thr Ala
            1300                1305                1310        
Ser Glu Ser Ser Asp Phe Thr Ser Glu Arg Arg Gly Asp Lys Glu Ala
        1315                1320                1325            
Pro Pro Pro Val Leu Leu Thr Pro Lys Ala Val Gly Thr Pro Gly Gly
    1330                1335                1340                
Gly Gly Gly Gly Ala Val Pro Gly Ile Ser Ala Met Ser Arg Gly Asp
1345                1350                1355                1360
Leu Ser Gln Arg Ala Lys Asp Leu Ser Lys Arg Ser Phe Ser Ser Gln
                1365                1370                1375    
Arg Pro Gly Met Glu Arg Gln Asn Arg Arg Pro Gly Pro Gly Gly Lys
            1380                1385                1390        
Ala Gly Ser Ser Gly Ser Ser Ser Gly Gly Gly Gly Gly Gly Pro Gly
        1395                1400                1405            
Gly Arg Thr Gly Pro Gly Arg Gly Asp Lys Arg Ser Trp Pro Ser Pro
    1410                1415                1420                
Lys Asn Arg Ser Arg Pro Pro Glu Glu Arg Pro Pro Gly Leu Pro Leu
1425                1430                1435                1440
Pro Pro Pro Pro Pro Ser Ser Ser Ala Val Phe Arg Leu Asp Gln Val
                1445                1450                1455    
Ile His Ser Asn Pro Ala Gly Ile Gln Gln Ala Leu Ala Gln Leu Ser
            1460                1465                1470        
Ser Arg Gln Gly Ser Val Thr Ala Pro Gly Gly His Pro Arg His Lys
        1475                1480                1485            
Pro Gly Pro Pro Gln Ala Pro Gln Gly Pro Ser Pro Arg Pro Pro Thr
    1490                1495                1500                
Arg Tyr Glu Pro Gln Arg Val Asn Ser Gly Leu Ser Ser Asp Pro His
1505                1510                1515                1520
Phe Glu Glu Pro Gly Pro Met Val Arg Gly Val Gly Gly Thr Pro Arg
                1525                1530                1535    
Asp Ser Ala Gly Val Ser Pro Phe Pro Pro Lys Arg Arg Glu Arg Pro
            1540                1545                1550        
Pro Arg Lys Pro Glu Leu Leu Gln Glu Glu Ser Leu Pro Pro Pro His
        1555                1560                1565            
Ser Ser Gly Phe Leu Gly Ser Lys Pro Glu Gly Pro Gly Pro Gln Ala
    1570                1575                1580                
Glu Ser Arg Asp Thr Gly Thr Glu Ala Leu Thr Pro His Ile Trp Asn
1585                1590                1595                1600
Arg Leu His Thr Ala Thr Ser Arg Lys Ser Tyr Arg Pro Ser Ser Met
                1605                1610                1615    
Glu Pro Trp Met Glu Pro Leu Ser Pro Phe Glu Asp Val Ala Gly Thr
            1620                1625                1630        
Glu Met Ser Gln Ser Asp Ser Gly Val Asp Leu Ser Gly Asp Ser Gln
        1635                1640                1645            
Val Ser Ser Gly Pro Cys Ser Gln Arg Ser Ser Pro Asp Gly Gly Leu
    1650                1655                1660                
Lys Gly Ala Ala Glu Gly Pro Pro Lys Arg Pro Gly Gly Ser Ser Pro
1665                1670                1675                1680
Leu Asn Ala Val Pro Cys Glu Gly Pro Pro Gly Ser Glu Pro Pro Arg
                1685                1690                1695    
Arg Pro Pro Pro Ala Pro His Asp Gly Asp Arg Lys Glu Leu Pro Arg
            1700                1705                1710        
Glu Gln Pro Leu Pro Pro Gly Pro Ile Gly Thr Glu Arg Ser Gln His
        1715                1720                1725            
Thr Asp Arg Gly Thr Glu Pro Gly Pro Ile Arg Pro Ser His Arg Pro
    1730                1735                1740                
Gly Pro Pro Val Gln Phe Gly Thr Ser Asp Lys Asp Ser Asp Leu Arg
1745                1750                1755                1760
Leu Val Val Gly Asp Ser Leu Lys Ala Glu Lys Glu Leu Thr Ala Ser
                1765                1770                1775    
Val Thr Glu Ala Ile Pro Val Ser Arg Asp Trp Glu Leu Leu Pro Ser
            1780                1785                1790        
Ala Ala Ala Ser Ala Glu Pro Gln Ser Lys Asn Leu Asp Ser Gly His
        1795                1800                1805            
Cys Val Pro Glu Pro Ser Ser Ser Gly Gln Arg Leu Tyr Pro Glu Val
    1810                1815                1820                
Phe Tyr Gly Ser Ala Gly Pro Ser Ser Ser Gln Ile Ser Gly Gly Ala
1825                1830                1835                1840
Met Asp Ser Gln Leu His Pro Asn Ser Gly Gly Phe Arg Pro Gly Thr
                1845                1850                1855    
Pro Ser Leu His Pro Tyr Arg Ser Gln Pro Leu Tyr Leu Pro Pro Gly
            1860                1865                1870        
Pro Ala Pro Pro Ser Ala Leu Leu Ser Gly Val Ala Leu Lys Gly Gln
        1875                1880                1885            
Phe Leu Asp Phe Ser Thr Met Gln Ala Thr Glu Leu Gly Lys Leu Pro
    1890                1895                1900                
Ala Gly Gly Val Leu Tyr Pro Pro Pro Ser Phe Leu Tyr Ser Pro Ala
1905                1910                1915                1920
Phe Cys Pro Ser Pro Leu Pro Asp Thr Ser Leu Leu Gln Val Arg Gln
                1925                1930                1935    
Asp Leu Pro Ser Pro Ser Asp Phe Tyr Ser Thr Pro Leu Gln Pro Gly
            1940                1945                1950        
Gly Gln Ser Gly Phe Leu Pro Ser Gly Ala Pro Ala Gln Gln Met Leu
        1955                1960                1965            
Leu Pro Met Val Asp Ser Gln Leu Pro Val Val Asn Phe Gly Ser Leu
    1970                1975                1980                
Pro Pro Ala Pro Pro Pro Ala Pro Pro Pro Leu Ser Leu Leu Pro Val
1985                1990                1995                2000
Gly Pro Ala Leu Gln Pro Pro Ser Leu Ala Val Arg Pro Pro Pro Ala
                2005                2010                2015    
Pro Ala Thr Arg Val Leu Pro Ser Pro Ala Arg Pro Phe Pro Ala Ser
            2020                2025                2030        
Leu Gly Arg Ala Glu Leu His Pro Val Glu Leu Lys Pro Phe Gln Asp
        2035                2040                2045            
Tyr Gln Lys Leu Ser Ser Asn Leu Gly Gly Pro Gly Ser Ser Arg Thr
    2050                2055                2060                
Pro Pro Thr Gly Arg Ser Phe Ser Gly Leu Asn Ser Arg Leu Lys Ala
2065                2070                2075                2080
Thr Pro Ser Thr Tyr Ser Gly Val Phe Arg Thr Gln Arg Val Asp Leu
                2085                2090                2095    
Tyr Gln Gln Ala Ser Pro Pro Asp Ala Leu Arg Trp Ile Pro Lys Pro
            2100                2105                2110        
Trp Glu Arg Thr Gly Leu Pro Pro Arg Glu Gly Pro Ser Arg Arg Ala
        2115                2120                2125            
Glu Glu Pro Gly Ser Arg Gly Asp Lys Glu Pro Gly Leu Pro Pro Pro
    2130                2135                2140                
Arg
2145


<210> 8350
<211> 544
<212> PRT
<213> Homo sapiens

<400> 8350
Met Ile His Val Arg Arg His Glu Thr Arg Arg Asn Ser Lys Ser His
 1               5                  10                  15      
Val Pro Glu Gln Lys Ser Arg Val Asp Trp Arg Arg Thr Lys Arg Ser
            20                  25                  30          
Ser Ile Ser Gln Leu Leu Asp Ser Asp Glu Glu Leu Asp Ser Glu Glu
        35                  40                  45              
Phe Asp Ser Asp Glu Glu Leu Asp Ser Asp Glu Ser Phe Glu Asn Asp
    50                  55                  60                  
Glu Glu Leu Asp Ser Asn Lys Gly Pro Asp Cys Asn Lys Thr Pro Gly
65                  70                  75                  80  
Ser Glu Arg Glu Leu Asn Leu Ser Lys Ile Gln Ser Glu Gly Asn Asp
                85                  90                  95      
Ser Lys Cys Leu Ile Asn Ser Gly Asn Gly Ser Thr Tyr Glu Glu Glu
            100                 105                 110         
Thr Asn Lys Ile Lys His Arg Asn Ile Asp Leu Gln Asp Gln Glu Lys
        115                 120                 125             
His Leu Ser Gln Glu Asp Asn Asp Leu Asn Lys Gln Thr Gly Gln Ile
    130                 135                 140                 
Ile Glu Asp Asp Gln Glu Lys His Leu Ser Gln Glu Asp Asn Asp Leu
145                 150                 155                 160 
Asn Lys Gln Thr Gly Gln Ile Ile Glu Asp Asp Leu Glu Glu Glu Asp
                165                 170                 175     
Ile Lys Arg Gly Lys Arg Lys Arg Leu Ser Ser Val Met Cys Asp Ser
            180                 185                 190         
Asp Glu Ser Asp Asp Ser Asp Ile Leu Val Arg Lys Val Gly Val Lys
        195                 200                 205             
Arg Pro Arg Arg Val Val Glu Asp Glu Gly Ser Ser Val Glu Met Glu
    210                 215                 220                 
Gln Lys Thr Pro Glu Lys Thr Leu Ala Ala Gln Lys Arg Glu Lys Leu
225                 230                 235                 240 
Gln Lys Leu Lys Glu Leu Ser Lys Gln Arg Ser Arg Gln Arg Arg Ser
                245                 250                 255     
Ser Gly Arg Asp Phe Glu Asp Ser Glu Lys Glu Ser Cys Pro Ser Ser
            260                 265                 270         
Asp Glu Val Asp Glu Glu Glu Glu Glu Asp Asn Tyr Glu Ser Asp Glu
        275                 280                 285             
Asp Gly Asp Asp Tyr Ile Ile Asp Asp Phe Val Val Gln Asp Glu Glu
    290                 295                 300                 
Gly Asp Glu Glu Asn Lys Asn Gln Gln Gly Glu Lys Leu Thr Thr Ser
305                 310                 315                 320 
Gln Leu Lys Leu Val Lys Arg Asn Ser Leu Tyr Ser Phe Ser Asp His
                325                 330                 335     
Tyr Thr His Phe Glu Arg Val Val Lys Ala Leu Leu Ile Asn Ala Leu
            340                 345                 350         
Asp Glu Ser Phe Leu Gly Thr Leu Tyr Asp Gly Thr Arg Gln Lys Ser
        355                 360                 365             
Tyr Ala Lys Asp Met Leu Thr Ser Leu His Tyr Leu Asp Asn Arg Phe
    370                 375                 380                 
Val Gln Pro Arg Leu Glu Ser Leu Val Ser Arg Ser Arg Trp Lys Glu
385                 390                 395                 400 
Gln Tyr Lys Glu Arg Val Glu Asn Tyr Ser Asn Val Ser Ile His Leu
                405                 410                 415     
Lys Asn Pro Glu Asn Cys Ser Cys Gln Ala Cys Gly Leu His Arg Tyr
            420                 425                 430         
Cys Lys Tyr Ser Val His Leu Ser Gly Glu Leu Tyr Asn Thr Arg Thr
        435                 440                 445             
Met Gln Ile Asp Asn Phe Met Ser His Asp Lys Gln Val Phe Thr Val
    450                 455                 460                 
Gly Arg Ile Cys Ala Ser Arg Thr Arg Ile Tyr His Lys Leu Lys His
465                 470                 475                 480 
Phe Lys Phe Lys Leu Tyr Gln Glu Cys Cys Thr Ile Ala Met Thr Glu
                485                 490                 495     
Glu Val Glu Asp Glu Gln Val Lys Glu Thr Val Glu Arg Ile Phe Arg
            500                 505                 510         
Arg Ser Lys Glu Asn Gly Trp Ile Lys Glu Lys Tyr Gly Gln Leu Glu
        515                 520                 525             
Glu Tyr Leu Asn Phe Ala Asp Tyr Phe Gln Glu Glu Lys Phe Glu Leu
    530                 535                 540                 


<210> 8351
<211> 544
<212> PRT
<213> Homo sapiens

<400> 8351
Met Ile His Val Arg Arg His Glu Thr Arg Arg Asn Ser Lys Ser His
 1               5                  10                  15      
Val Pro Glu Gln Lys Ser Arg Val Asp Trp Arg Arg Thr Lys Arg Ser
            20                  25                  30          
Ser Ile Ser Gln Leu Leu Asp Ser Asp Glu Glu Leu Asp Ser Glu Glu
        35                  40                  45              
Phe Asp Ser Asp Glu Glu Leu Asp Ser Asp Glu Ser Phe Glu Asn Asp
    50                  55                  60                  
Glu Glu Leu Asp Ser Asn Lys Gly Pro Asp Cys Asn Lys Thr Pro Gly
65                  70                  75                  80  
Ser Glu Arg Glu Leu Asn Leu Ser Lys Ile Gln Ser Glu Gly Asn Asp
                85                  90                  95      
Ser Lys Cys Leu Ile Asn Ser Gly Asn Gly Ser Thr Tyr Glu Glu Glu
            100                 105                 110         
Thr Asn Lys Ile Lys His Arg Asn Ile Asp Leu Gln Asp Gln Glu Lys
        115                 120                 125             
His Leu Ser Gln Glu Asp Asn Asp Leu Asn Lys Gln Thr Gly Gln Ile
    130                 135                 140                 
Ile Glu Asp Asp Gln Glu Lys His Leu Ser Gln Glu Asp Asn Asp Leu
145                 150                 155                 160 
Asn Lys Gln Thr Gly Gln Ile Ile Glu Asp Asp Leu Glu Glu Glu Asp
                165                 170                 175     
Ile Lys Arg Gly Lys Arg Lys Arg Leu Ser Ser Val Met Cys Asp Ser
            180                 185                 190         
Asp Glu Ser Asp Asp Ser Asp Ile Leu Val Arg Lys Val Gly Val Lys
        195                 200                 205             
Arg Pro Arg Arg Val Val Glu Asp Glu Gly Ser Ser Val Glu Met Glu
    210                 215                 220                 
Gln Lys Thr Pro Glu Lys Thr Leu Ala Ala Gln Lys Arg Glu Lys Leu
225                 230                 235                 240 
Gln Lys Leu Lys Glu Leu Ser Lys Gln Arg Ser Arg Gln Arg Arg Ser
                245                 250                 255     
Ser Gly Arg Asp Phe Glu Asp Ser Glu Lys Glu Ser Cys Pro Ser Ser
            260                 265                 270         
Asp Glu Val Asp Glu Glu Glu Glu Glu Asp Asn Tyr Glu Ser Asp Glu
        275                 280                 285             
Asp Gly Asp Asp Tyr Ile Ile Asp Asp Phe Val Val Gln Asp Glu Glu
    290                 295                 300                 
Gly Asp Glu Glu Asn Lys Asn Gln Gln Gly Glu Lys Leu Thr Thr Ser
305                 310                 315                 320 
Gln Leu Lys Leu Val Lys Gln Asn Ser Leu Tyr Ser Phe Ser Asp His
                325                 330                 335     
Tyr Thr His Phe Glu Arg Val Val Lys Ala Leu Leu Ile Asn Ala Leu
            340                 345                 350         
Asp Glu Ser Phe Leu Gly Thr Leu Tyr Asp Gly Thr Arg Gln Lys Ser
        355                 360                 365             
Tyr Ala Lys Asp Met Leu Thr Ser Leu His Tyr Leu Asp Asn Arg Phe
    370                 375                 380                 
Val Gln Pro Arg Leu Glu Ser Leu Val Ser Arg Ser Arg Trp Lys Glu
385                 390                 395                 400 
Gln Tyr Lys Glu Arg Val Glu Asn Tyr Ser Asn Val Ser Ile His Leu
                405                 410                 415     
Lys Asn Pro Glu Asn Cys Ser Cys Gln Ala Cys Gly Leu His Arg Tyr
            420                 425                 430         
Cys Lys Tyr Ser Val His Leu Ser Gly Glu Leu Tyr Asn Thr Arg Thr
        435                 440                 445             
Met Gln Ile Asp Asn Phe Met Ser His Asp Lys Gln Val Phe Thr Val
    450                 455                 460                 
Gly Arg Ile Cys Ala Ser Arg Thr Arg Ile Tyr His Lys Leu Lys His
465                 470                 475                 480 
Phe Lys Phe Lys Leu Tyr Gln Glu Cys Cys Thr Ile Ala Met Thr Glu
                485                 490                 495     
Glu Val Glu Asp Glu Gln Val Lys Glu Thr Val Glu Arg Ile Phe Arg
            500                 505                 510         
Arg Ser Lys Glu Asn Gly Trp Ile Lys Glu Lys Tyr Gly Gln Leu Glu
        515                 520                 525             
Glu Tyr Leu Asn Phe Ala Asp Tyr Phe Gln Glu Glu Lys Phe Glu Leu
    530                 535                 540                 


<210> 8352
<211> 198
<212> PRT
<213> Homo sapiens

<400> 8352
Met Lys Leu Tyr Ser Leu Ser Val Leu Tyr Lys Gly Glu Ala Lys Val
 1               5                  10                  15      
Val Leu Leu Lys Ala Ala Tyr Asp Val Ser Ser Phe Ser Phe Phe Gln
            20                  25                  30          
Arg Ser Ser Val Gln Glu Phe Met Thr Phe Thr Ser Gln Leu Ile Val
        35                  40                  45              
Glu Arg Ser Ser Lys Gly Thr Arg Ala Ser Val Lys Glu Gln Asp Tyr
    50                  55                  60                  
Leu Cys His Val Tyr Val Arg Asn Asp Ser Leu Ala Gly Val Val Ile
65                  70                  75                  80  
Ala Asp Asn Glu Tyr Pro Ser Arg Val Ala Phe Thr Leu Leu Glu Lys
                85                  90                  95      
Val Leu Asp Glu Phe Ser Lys Gln Val Asp Arg Ile Asp Trp Pro Val
            100                 105                 110         
Gly Ser Pro Ala Thr Ile His Tyr Pro Ala Leu Asp Gly His Leu Ser
        115                 120                 125             
Arg Tyr Gln Asn Pro Arg Glu Ala Asp Pro Met Thr Lys Val Gln Ala
    130                 135                 140                 
Glu Leu Asp Glu Thr Lys Ile Ile Leu His Asn Thr Met Glu Ser Leu
145                 150                 155                 160 
Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val
                165                 170                 175     
Leu Gly Thr Gln Ser Lys Ala Phe Tyr Lys Thr Ala Arg Lys Gln Asn
            180                 185                 190         
Ser Cys Cys Ala Ile Met
        195             


<210> 8353
<211> 811
<212> PRT
<213> Homo sapiens

<400> 8353
Arg Trp Cys His Lys Gly Ala Gly Arg Gly Gly Ser Gly Ala Leu Ser
 1               5                  10                  15      
Ala Ser Ala Phe Arg Glu Val Ala Arg Arg Val Val Gly Pro Cys Arg
            20                  25                  30          
Pro Val Gly Gly Arg Ala Ser Gln Arg Thr Arg Leu Arg Val Gln Asn
        35                  40                  45              
Ser Lys His Glu Gln Gln Tyr Ile Leu Pro Ile Phe Lys Pro Gly Leu
    50                  55                  60                  
Pro Arg Thr Gly Ile Gln Leu Pro Ala Thr Tyr Phe Arg Arg Thr Arg
65                  70                  75                  80  
Lys Val Lys Val Met Asp Asn Arg Lys Glu Pro Pro Phe Phe Asn Asp
                85                  90                  95      
Asp Asn Met Gly Pro Phe Tyr Tyr Arg Leu His Phe Cys Asp Thr Met
            100                 105                 110         
Glu Leu Phe Ile Glu Thr Leu Thr Gly Thr Cys Phe Glu Leu Arg Val
        115                 120                 125             
Ser Pro Phe Glu Thr Val Ile Ser Val Lys Ala Lys Ile Arg Arg Leu
    130                 135                 140                 
Glu Gly Ile Pro Ile Cys Arg Gln His Leu Ile Trp Asn Asn Met Glu
145                 150                 155                 160 
Leu Glu Asn Asp Tyr Cys Leu Asn Asp Tyr Asn Ile Ser Glu Gly Cys
                165                 170                 175     
Thr Leu Lys Leu Val Leu Ala Met Arg Gly Gly Pro Ile Asn Thr Arg
            180                 185                 190         
Arg Val Pro Thr Asp Asp Pro Leu Arg Lys Met Ala Glu Tyr Leu Asp
        195                 200                 205             
Ser Ser Arg Val Glu Val Trp Glu Lys Thr Ser Cys Ser Lys Gln Val
    210                 215                 220                 
Thr Phe Leu Val Tyr Gln Glu Gly Asp Gln Leu Asn Phe Phe Pro Ala
225                 230                 235                 240 
Val Asp Arg Gly Asp Gly Thr Leu Thr Pro Leu Ser Asp Ser Ser Lys
                245                 250                 255     
Lys Ile Asp Phe His Leu His Val Leu Arg Arg Lys Gly Glu His Arg
            260                 265                 270         
Met Ser Gly Gly Ser Met Tyr Asn Ser Asp Thr Asp Glu Asp Glu Glu
        275                 280                 285             
Thr Glu Pro Ser Ser Ser Gly Gln Gln Ile Ile Glu Asn Ser Ile Thr
    290                 295                 300                 
Met Asn Lys Met Lys Leu Leu Lys Ala Lys Met Lys Asn Met Asn Leu
305                 310                 315                 320 
Ser Lys Lys Pro Lys Lys Ala Val Lys Ile Lys Pro His Pro Pro Val
                325                 330                 335     
Ala Pro Arg Pro Ser Ser Gly Ser Thr Ala Pro Ser Arg His Arg Leu
            340                 345                 350         
Leu Arg Val Leu Pro Asn Ile Gly Gln Ser Cys Ser Pro Ala Phe Gly
        355                 360                 365             
Asn Ala Tyr Pro Pro Glu Ile Ser Arg Asn Gly Ile Ser Ser Leu Ala
    370                 375                 380                 
Thr Gln Leu Ser Ala Glu Arg Tyr Ile Ser Ser Ile Thr Gly Glu Phe
385                 390                 395                 400 
Leu Lys Glu Asp Asn Ser Trp Glu Asn Asn Thr Leu Ser His Phe Ser
                405                 410                 415     
Ser Asn Val Lys Leu Pro Pro Gln Ile Pro His Leu Glu Leu Gly Asn
            420                 425                 430         
Asp Gln Glu Leu Ala Asp Ser Val Leu His Leu Gly Ser Ser Leu Pro
        435                 440                 445             
Arg Gln Thr Lys His Phe Leu Gly Asn Leu Pro Ser Ser Asn Gly Asn
    450                 455                 460                 
Ile Val Leu Pro Ser Glu Glu Cys Val Thr Glu Gln Ser Leu Leu Pro
465                 470                 475                 480 
Lys Val Gly Ser Leu Ala Ser Phe Ala Glu Gly Asn Ala Asp Glu Gln
                485                 490                 495     
Ser Ser Gly Leu Glu Gly Ala Cys Lys Val Asn Leu Glu Leu Leu Leu
            500                 505                 510         
Thr Asn Ala Asp Lys Gly Leu Lys Ala Pro Glu Gln His Leu Lys His
        515                 520                 525             
Val Ala Gly Val Leu Asn Gly Glu Ser Val Glu Thr Ser Val Leu Asn
    530                 535                 540                 
Tyr Arg Glu Leu Ser Pro His Lys Asn Arg Leu Leu Ser Pro Leu Arg
545                 550                 555                 560 
Cys Ser Ala Pro Met Ser Leu His Asn Ser Leu Val Lys Pro Glu Arg
                565                 570                 575     
Gln Ser Lys Cys Phe Glu Phe Gly Lys Leu Gln Pro Ser Ser Ser Gln
            580                 585                 590         
Ser Leu Asp Val Gln Asn Ile Thr Asp Ser Ser Phe Ser Arg Thr Thr
        595                 600                 605             
Cys Phe Gln Gly Val Lys Val Asp Ser Leu Gly Lys Arg Ser Asp Val
    610                 615                 620                 
Ile Ser Lys Val Glu Ala Arg Asp Ile Thr Glu Met Thr Asn Lys Ala
625                 630                 635                 640 
Ser Lys Glu Pro Val Gly Cys Val Asn Asn Ile Ser Phe Leu Ala Ser
                645                 650                 655     
Leu Ala Gly Ser Thr Ser Arg Asn Arg Leu Gln Ser Thr Arg Gly Ala
            660                 665                 670         
Gly Arg Leu Gln Asn Ser Gly Thr Gly Leu Ser Thr Asn Leu Gln His
        675                 680                 685             
Phe Gln Glu Glu Asn Phe Arg Lys Ser Ser Pro Gln Leu Glu His Thr
    690                 695                 700                 
Gly Val Phe Leu Ser Thr His Gly Val Gly Met Asn Gly Asn Asn Ala
705                 710                 715                 720 
Ala Ala Gly Lys Ser Val Gly Glu Cys Thr Thr His His Leu Pro Pro
                725                 730                 735     
Val Lys Ala Pro Leu Gln Thr Lys Lys Lys Thr Thr Asn His Cys Phe
            740                 745                 750         
Leu Cys Gly Lys Lys Thr Gly Leu Ala Ser Ser Tyr Glu Cys Arg Cys
        755                 760                 765             
Gly Asn Asn Phe Cys Ala Ser His Arg Tyr Ala Glu Thr His Gly Cys
    770                 775                 780                 
Thr Tyr Asp Tyr Lys Ser Ala Gly Arg Arg Tyr Leu His Glu Ala Asn
785                 790                 795                 800 
Pro Val Val Asn Ala Pro Lys Leu Pro Lys Ile
                805                 810     


<210> 8354
<211> 2288
<212> PRT
<213> Homo sapiens

<400> 8354
Met Ser Asp Asp Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys
 1               5                  10                  15      
Arg Trp Cys Ala Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His
            20                  25                  30          
Asn Ala Phe Cys Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu
        35                  40                  45              
Leu Ser Thr Ile Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile Cys
    50                  55                  60                  
His Pro Glu Pro Leu Leu Asp Leu Val Thr Ala Cys Asn Ser Val Phe
65                  70                  75                  80  
Glu Asn Leu Glu Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys Val
                85                  90                  95      
Asp Ser Glu Lys Ser Asn Lys Val Tyr Glu His Thr Ser Arg Phe Ser
            100                 105                 110         
Pro Lys Lys Thr Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu Asp
        115                 120                 125             
Asp Ser Cys Ser Gly Ser Val Thr Tyr Ser Tyr Ser Ala Leu Ile Val
    130                 135                 140                 
Pro Lys Glu Met Ile Lys Lys Ala Lys Lys Leu Ile Glu Thr Thr Ala
145                 150                 155                 160 
Asn Met Asn Ser Ser Tyr Val Lys Phe Leu Lys Gln Ala Thr Asp Asn
                165                 170                 175     
Ser Glu Ile Ser Ser Ala Thr Lys Leu Arg Gln Leu Lys Ala Phe Lys
            180                 185                 190         
Ser Val Leu Ala Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu Asp
        195                 200                 205             
Leu Asn Ser Glu Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys Asn
    210                 215                 220                 
Thr Lys Glu His Lys Val Ile Asp Ala Lys Phe Glu Thr Lys Ala Arg
225                 230                 235                 240 
Lys Gly Glu Lys Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys Ser
                245                 250                 255     
Glu Ala Lys Leu Ser Arg Lys Gln Val Asp Ser Glu His Met His Gln
            260                 265                 270         
Asn Val Pro Thr Glu Glu Gln Arg Thr Asn Lys Ser Thr Gly Gly Glu
        275                 280                 285             
His Lys Lys Ser Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala Asn
    290                 295                 300                 
Thr Ser Glu Asp Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser Val
305                 310                 315                 320 
Pro Glu Asp Ile Phe Glu Asn Leu Glu Thr Ala Met Glu Val Gln Ser
                325                 330                 335     
Ser Val Asp His Gln Gly Asp Gly Ser Ser Gly Thr Glu Gln Glu Val
            340                 345                 350         
Glu Ser Ser Ser Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg Gly
        355                 360                 365             
Gly Ile Lys Ser Lys Thr Thr Ala Lys Val Thr Lys Glu Leu Tyr Val
    370                 375                 380                 
Lys Leu Thr Pro Val Ser Leu Pro Asn Ser Pro Ile Lys Gly Ala Asp
385                 390                 395                 400 
Cys Gln Glu Val Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly Leu
                405                 410                 415     
Asn Pro Lys Leu Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp Asn
            420                 425                 430         
Glu His Leu Val Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser Asp
        435                 440                 445             
Leu Arg Arg Ser Pro Arg Val Lys Thr Thr Pro Leu Arg Arg Pro Thr
    450                 455                 460                 
Glu Thr Asn Pro Val Thr Ser Asn Ser Asp Glu Glu Cys Asn Glu Thr
465                 470                 475                 480 
Val Lys Glu Lys Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp Lys
                485                 490                 495     
Arg Asn Ser Ser Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys Leu
            500                 505                 510         
Pro Lys Ser Lys Gln Ser Glu Thr Val Asp Gln Asn Ser Asp Ser Asp
        515                 520                 525             
Glu Met Leu Ala Ile Leu Lys Gly Val Ser Arg Met Ser His Ser Ser
    530                 535                 540                 
Ser Ser Asp Thr Asp Ile Asn Glu Ile His Thr Asn His Lys Thr Leu
545                 550                 555                 560 
Tyr Asp Leu Lys Thr Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg Lys
                565                 570                 575     
Arg Lys Ser Ser Thr Ser Gly Ser Asp Phe Asp Thr Lys Lys Gly Lys
            580                 585                 590         
Ser Ala Lys Ser Ser Ile Ile Ser Lys Lys Lys Arg Gln Thr Gln Ser
        595                 600                 605             
Glu Ser Ser Asn Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser Met
    610                 615                 620                 
Ser Lys Ile Gly Ala Ala Arg Thr Thr Lys Lys Arg Ile Pro Asn Thr
625                 630                 635                 640 
Lys Asp Phe Asp Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly Met
                645                 650                 655     
Asp Asn Gln Gly His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser Ser
            660                 665                 670         
Asp Asp Ala Glu Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala Glu
        675                 680                 685             
Gly Thr Val Asp Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg Leu
    690                 695                 700                 
Pro Lys Lys Gln Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys Leu
705                 710                 715                 720 
Ser Gly Lys Glu Gln Ser Phe Thr Ser Leu Glu Val Arg Lys Val Ala
                725                 730                 735     
Glu Thr Lys Glu Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys Lys
            740                 745                 750         
Val Gln Asp Gly Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys Asp
        755                 760                 765             
Gln Ser Asp Glu Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys Gly
    770                 775                 780                 
Thr Glu Glu Lys Lys Lys Pro Ser Asp Phe Lys Lys Lys Val Ile Lys
785                 790                 795                 800 
Met Glu Gln Gln Tyr Glu Ser Ser Ser Asp Gly Thr Glu Lys Leu Pro
                805                 810                 815     
Glu Arg Glu Glu Ile Cys His Phe Pro Lys Gly Ile Lys Gln Ile Lys
            820                 825                 830         
Asn Gly Thr Thr Asp Gly Glu Lys Lys Ser Lys Lys Ile Arg Asp Lys
        835                 840                 845             
Thr Ser Lys Lys Lys Asp Glu Leu Ser Asp Tyr Ala Glu Lys Ser Thr
    850                 855                 860                 
Gly Lys Gly Asp Ser Cys Asp Ser Ser Glu Asp Lys Lys Ser Lys Asn
865                 870                 875                 880 
Gly Ala Tyr Gly Arg Glu Lys Lys Arg Cys Lys Leu Leu Gly Lys Ser
                885                 890                 895     
Ser Arg Lys Arg Gln Asp Cys Ser Ser Ser Asp Thr Glu Lys Tyr Ser
            900                 905                 910         
Met Lys Glu Asp Gly Cys Asn Ser Ser Asp Lys Arg Leu Lys Arg Ile
        915                 920                 925             
Glu Leu Arg Glu Arg Arg Asn Leu Ser Ser Lys Arg Asn Thr Lys Glu
    930                 935                 940                 
Ile Gln Ser Gly Ser Ser Ser Ser Asp Ala Glu Glu Ser Ser Glu Asp
945                 950                 955                 960 
Asn Lys Lys Lys Lys Gln Arg Thr Ser Ser Lys Lys Lys Ala Val Ile
                965                 970                 975     
Val Lys Glu Lys Lys Arg Asn Ser Leu Arg Thr Ser Thr Lys Arg Lys
            980                 985                 990         
Gln Ala Asp Ile Thr Ser Ser Ser Ser Ser Asp Ile Glu Asp Asp Asp
        995                 1000                1005            
Gln Asn Ser Ile Gly Glu Gly Ser Ser Asp Glu Gln Lys Ile Lys Pro
    1010                1015                1020                
Val Thr Glu Asn Leu Val Leu Ser Ser His Thr Gly Phe Cys Gln Ser
1025                1030                1035                1040
Ser Gly Asp Glu Ala Leu Ser Lys Ser Val Pro Val Thr Val Asp Asp
                1045                1050                1055    
Asp Asp Asp Asp Asn Asp Pro Glu Asn Arg Ile Ala Lys Lys Met Leu
            1060                1065                1070        
Leu Glu Glu Ile Lys Ala Asn Leu Ser Ser Asp Glu Asp Gly Ser Ser
        1075                1080                1085            
Asp Asp Glu Pro Glu Glu Gly Lys Lys Arg Thr Gly Lys Gln Asn Glu
    1090                1095                1100                
Glu Asn Pro Gly Asp Glu Glu Ala Lys Asn Gln Val Asn Ser Glu Ser
1105                1110                1115                1120
Asp Ser Asp Ser Glu Glu Ser Lys Lys Pro Arg Tyr Arg His Arg Leu
                1125                1130                1135    
Leu Arg His Lys Leu Thr Val Ser Asp Gly Glu Ser Gly Glu Glu Lys
            1140                1145                1150        
Lys Thr Lys Pro Lys Glu His Lys Glu Val Lys Gly Arg Asn Arg Arg
        1155                1160                1165            
Lys Val Ser Ser Glu Asp Ser Glu Asp Ser Asp Phe Gln Glu Ser Gly
    1170                1175                1180                
Val Ser Glu Glu Val Ser Glu Ser Glu Asp Glu Gln Arg Pro Arg Thr
1185                1190                1195                1200
Arg Ser Ala Lys Lys Ala Glu Leu Glu Glu Asn Gln Arg Ser Tyr Lys
                1205                1210                1215    
Gln Lys Lys Lys Arg Arg Arg Ile Lys Val Gln Glu Asp Ser Ser Ser
            1220                1225                1230        
Glu Asn Lys Ser Asn Ser Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu
        1235                1240                1245            
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asn Asp
    1250                1255                1260                
Asp Ser Lys Ser Pro Gly Lys Gly Arg Lys Lys Ile Arg Lys Ile Leu
1265                1270                1275                1280
Lys Asp Asp Lys Leu Arg Thr Glu Thr Gln Asn Ala Leu Lys Glu Glu
                1285                1290                1295    
Glu Glu Arg Arg Lys Arg Ile Ala Glu Arg Glu Arg Glu Arg Glu Lys
            1300                1305                1310        
Leu Arg Glu Val Ile Glu Ile Glu Asp Ala Ser Pro Thr Lys Cys Pro
        1315                1320                1325            
Ile Thr Thr Lys Leu Val Leu Asp Glu Asp Glu Glu Thr Lys Glu Pro
    1330                1335                1340                
Leu Val Gln Val His Arg Asn Met Val Ile Lys Leu Lys Pro His Gln
1345                1350                1355                1360
Val Asp Gly Val Gln Phe Met Trp Asp Cys Cys Cys Glu Ser Val Lys
                1365                1370                1375    
Lys Thr Lys Lys Ser Pro Gly Ser Gly Cys Ile Leu Ala His Cys Met
            1380                1385                1390        
Gly Leu Gly Lys Thr Leu Gln Val Val Ser Phe Leu His Thr Val Leu
        1395                1400                1405            
Leu Cys Asp Lys Leu Asp Phe Ser Thr Ala Leu Val Val Cys Pro Leu
    1410                1415                1420                
Asn Thr Ala Leu Asn Trp Met Asn Glu Phe Glu Lys Trp Gln Glu Gly
1425                1430                1435                1440
Leu Lys Asp Asp Glu Lys Leu Glu Val Ser Glu Leu Ala Thr Val Lys
                1445                1450                1455    
Arg Pro Gln Glu Arg Ser Tyr Met Leu Gln Arg Trp Gln Glu Asp Gly
            1460                1465                1470        
Gly Val Met Ile Ile Gly Tyr Glu Met Tyr Arg Asn Leu Ala Gln Gly
        1475                1480                1485            
Arg Asn Val Lys Ser Arg Lys Leu Lys Glu Ile Phe Asn Lys Ala Leu
    1490                1495                1500                
Val Asp Pro Gly Pro Asp Phe Val Val Cys Asp Glu Gly His Ile Leu
1505                1510                1515                1520
Lys Asn Glu Ala Ser Ala Val Ser Lys Ala Met Asn Ser Ile Arg Ser
                1525                1530                1535    
Arg Arg Arg Ile Ile Leu Thr Gly Thr Pro Leu Gln Asn Asn Leu Ile
            1540                1545                1550        
Glu Tyr His Cys Met Val Asn Phe Ile Lys Glu Asn Leu Leu Gly Ser
        1555                1560                1565            
Ile Lys Glu Phe Arg Asn Arg Phe Ile Asn Pro Ile Gln Asn Gly Gln
    1570                1575                1580                
Cys Ala Asp Ser Thr Met Val Asp Val Arg Val Met Lys Lys Arg Ala
1585                1590                1595                1600
His Ile Leu Tyr Glu Met Leu Ala Gly Cys Val Gln Arg Lys Asp Tyr
                1605                1610                1615    
Thr Ala Leu Thr Lys Phe Leu Pro Pro Lys His Glu Tyr Val Leu Ala
            1620                1625                1630        
Val Arg Met Thr Ser Ile Gln Cys Lys Leu Tyr Gln Tyr Tyr Leu Asp
        1635                1640                1645            
His Leu Thr Gly Val Gly Asn Asn Ser Glu Gly Gly Arg Gly Lys Ala
    1650                1655                1660                
Gly Ala Lys Leu Phe Gln Asp Phe Gln Met Leu Ser Arg Ile Trp Thr
1665                1670                1675                1680
His Pro Trp Cys Leu Gln Leu Asp Tyr Ile Ser Lys Glu Asn Lys Gly
                1685                1690                1695    
Tyr Phe Asp Glu Asp Ser Met Asp Glu Phe Ile Ala Ser Asp Ser Asp
            1700                1705                1710        
Glu Thr Ser Met Ser Leu Ser Ser Asp Asp Tyr Thr Lys Lys Lys Lys
        1715                1720                1725            
Lys Gly Lys Lys Gly Lys Lys Asp Ser Ser Ser Ser Gly Ser Gly Ser
    1730                1735                1740                
Asp Asn Asp Val Glu Val Ile Lys Val Trp Asn Ser Arg Ser Arg Gly
1745                1750                1755                1760
Gly Gly Glu Gly Asn Val Asp Glu Thr Gly Asn Asn Pro Ser Val Ser
                1765                1770                1775    
Leu Lys Leu Glu Glu Ser Lys Ala Thr Ser Ser Ser Asn Pro Ser Ser
            1780                1785                1790        
Pro Ala Pro Asp Trp Tyr Lys Asp Phe Val Thr Asp Ala Asp Ala Glu
        1795                1800                1805            
Val Leu Glu His Ser Gly Lys Met Val Leu Leu Phe Glu Ile Leu Arg
    1810                1815                1820                
Met Ala Glu Glu Ile Gly Asp Lys Val Leu Val Phe Ser Gln Ser Leu
1825                1830                1835                1840
Ile Ser Leu Asp Leu Ile Glu Asp Phe Leu Glu Leu Ala Ser Arg Glu
                1845                1850                1855    
Lys Thr Glu Asp Lys Asp Lys Pro Leu Ile Tyr Lys Gly Glu Gly Lys
            1860                1865                1870        
Trp Leu Arg Asn Ile Asp Tyr Tyr Arg Leu Asp Gly Ser Thr Thr Ala
        1875                1880                1885            
Gln Ser Arg Lys Lys Trp Ala Glu Glu Phe Asn Asp Glu Thr Asn Val
    1890                1895                1900                
Arg Gly Arg Leu Phe Ile Ile Ser Thr Lys Ala Gly Ser Leu Gly Ile
1905                1910                1915                1920
Asn Leu Val Ala Ala Asn Arg Val Ile Ile Phe Asp Ala Ser Trp Asn
                1925                1930                1935    
Pro Ser Tyr Asp Ile Gln Ser Ile Phe Arg Val Tyr Arg Phe Gly Gln
            1940                1945                1950        
Thr Lys Pro Val Tyr Val Tyr Arg Phe Leu Ala Gln Gly Thr Met Glu
        1955                1960                1965            
Asp Lys Ile Tyr Asp Arg Gln Val Thr Lys Gln Ser Leu Ser Phe Arg
    1970                1975                1980                
Val Val Asp Gln Gln Gln Val Glu Arg His Phe Thr Met Asn Glu Leu
1985                1990                1995                2000
Thr Glu Leu Tyr Thr Phe Glu Pro Asp Leu Leu Asp Asp Pro Asn Ser
                2005                2010                2015    
Glu Lys Lys Lys Lys Arg Asp Thr Pro Met Leu Pro Lys Asp Thr Ile
            2020                2025                2030        
Leu Ala Glu Leu Leu Gln Ile His Lys Glu His Ile Val Gly Tyr His
        2035                2040                2045            
Glu His Asp Ser Leu Leu Asp His Lys Glu Glu Glu Glu Leu Thr Glu
    2050                2055                2060                
Glu Glu Arg Lys Ala Ala Trp Ala Glu Tyr Glu Ala Glu Lys Lys Val
2065                2070                2075                2080
Leu Thr Met Arg Phe Asn Ile Pro Thr Gly Thr Asn Leu Pro Pro Val
                2085                2090                2095    
Ser Phe Asn Ser Gln Thr Pro Tyr Ile Pro Phe Asn Leu Gly Ala Leu
            2100                2105                2110        
Ser Ala Met Ser Asn Gln Gln Leu Glu Asp Leu Ile Asn Gln Gly Arg
        2115                2120                2125            
Glu Lys Val Val Glu Ala Thr Asn Ser Val Thr Ala Val Arg Ile Gln
    2130                2135                2140                
Pro Leu Glu Asp Ile Ile Ser Ala Val Trp Lys Glu Asn Met Asn Leu
2145                2150                2155                2160
Ser Glu Ala Gln Val Gln Ala Leu Ala Leu Ser Arg Gln Ala Ser Gln
                2165                2170                2175    
Glu Leu Asp Val Lys Arg Arg Glu Ala Ile Tyr Asn Asp Val Leu Thr
            2180                2185                2190        
Lys Gln Gln Met Leu Ile Ser Cys Val Gln Arg Ile Leu Met Asn Arg
        2195                2200                2205            
Arg Leu Gln Gln Gln Tyr Asn Gln Gln Gln Gln Gln Gln Met Thr Tyr
    2210                2215                2220                
Gln Gln Ala Thr Leu Gly His Leu Met Met Pro Lys Pro Pro Asn Leu
2225                2230                2235                2240
Ile Met Asn Pro Ser Asn Tyr Gln Gln Ile Asp Met Arg Gly Met Tyr
                2245                2250                2255    
Gln Pro Val Ala Gly Gly Met Gln Pro Pro Pro Leu Gln Arg Ala Pro
            2260                2265                2270        
Pro Pro Met Arg Ser Lys Asn Pro Gly Pro Ser Gln Gly Lys Ser Met
        2275                2280                2285            


<210> 8355
<211> 2337
<212> PRT
<213> Homo sapiens

<400> 8355
Met Gln Ser Leu Pro Lys Glu Asp Gly Leu His Gly Ile Val Ser Cys
 1               5                  10                  15      
Thr Ala Cys Gly Gln Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr
            20                  25                  30          
Arg His Pro Ser Leu Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr
        35                  40                  45              
Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln
    50                  55                  60                  
Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys
65                  70                  75                  80  
His Asn Ala Phe Cys Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys
                85                  90                  95      
Glu Leu Ser Thr Ile Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile
            100                 105                 110         
Cys His Pro Glu Pro Leu Leu Asp Leu Val Thr Ala Cys Asn Ser Val
        115                 120                 125             
Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys
    130                 135                 140                 
Val Asp Ser Glu Lys Ser Asn Lys Val Tyr Glu His Thr Ser Arg Phe
145                 150                 155                 160 
Ser Pro Lys Lys Thr Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu
                165                 170                 175     
Asp Asp Ser Cys Ser Gly Ser Val Thr Tyr Ser Tyr Ser Ala Leu Ile
            180                 185                 190         
Val Pro Lys Glu Met Ile Lys Lys Ala Lys Lys Leu Ile Glu Thr Thr
        195                 200                 205             
Ala Asn Met Asn Ser Ser Tyr Val Lys Phe Leu Lys Gln Ala Thr Asp
    210                 215                 220                 
Asn Ser Glu Ile Ser Ser Ala Thr Lys Leu Arg Gln Leu Lys Ala Phe
225                 230                 235                 240 
Lys Ser Val Leu Ala Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu
                245                 250                 255     
Asp Leu Asn Ser Glu Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys
            260                 265                 270         
Asn Thr Lys Glu His Lys Val Ile Asp Ala Lys Phe Glu Thr Lys Ala
        275                 280                 285             
Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys
    290                 295                 300                 
Ser Glu Ala Lys Leu Ser Arg Lys Gln Val Asp Ser Glu His Met His
305                 310                 315                 320 
Gln Asn Val Pro Thr Glu Glu Gln Arg Thr Asn Lys Ser Thr Gly Gly
                325                 330                 335     
Glu His Lys Lys Ser Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala
            340                 345                 350         
Asn Thr Ser Glu Asp Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser
        355                 360                 365             
Val Pro Glu Asp Ile Phe Glu Asn Leu Glu Thr Ala Met Glu Val Gln
    370                 375                 380                 
Ser Ser Val Asp His Gln Gly Asp Gly Ser Ser Gly Thr Glu Gln Glu
385                 390                 395                 400 
Val Glu Ser Ser Ser Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg
                405                 410                 415     
Gly Gly Ile Lys Ser Lys Thr Thr Ala Lys Val Thr Lys Glu Leu Tyr
            420                 425                 430         
Val Lys Leu Thr Pro Val Ser Leu Pro Asn Ser Pro Ile Lys Gly Ala
        435                 440                 445             
Asp Cys Gln Glu Val Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly
    450                 455                 460                 
Leu Asn Pro Lys Leu Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp
465                 470                 475                 480 
Asn Glu His Leu Val Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser
                485                 490                 495     
Asp Leu Arg Arg Ser Pro Arg Val Lys Thr Thr Pro Leu Arg Arg Pro
            500                 505                 510         
Thr Glu Thr Asn Pro Val Thr Ser Asn Ser Asp Glu Glu Cys Asn Glu
        515                 520                 525             
Thr Val Lys Glu Lys Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp
    530                 535                 540                 
Lys Arg Asn Ser Ser Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys
545                 550                 555                 560 
Leu Pro Lys Ser Lys Gln Ser Glu Thr Val Asp Gln Asn Ser Asp Ser
                565                 570                 575     
Asp Glu Met Leu Ala Ile Leu Lys Gly Val Ser Arg Met Ser His Ser
            580                 585                 590         
Ser Ser Ser Asp Thr Asp Ile Asn Glu Ile His Thr Asn His Lys Thr
        595                 600                 605             
Leu Tyr Asp Leu Lys Thr Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg
    610                 615                 620                 
Lys Arg Lys Ser Ser Thr Ser Gly Ser Asp Phe Asp Thr Lys Lys Gly
625                 630                 635                 640 
Lys Ser Ala Lys Ser Ser Ile Ile Ser Lys Lys Lys Arg Gln Thr Gln
                645                 650                 655     
Ser Glu Ser Ser Asn Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser
            660                 665                 670         
Met Ser Lys Ile Gly Ala Ala Arg Thr Thr Lys Lys Arg Ile Pro Asn
        675                 680                 685             
Thr Lys Asp Phe Asp Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly
    690                 695                 700                 
Met Asp Asn Gln Gly His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser
705                 710                 715                 720 
Ser Asp Asp Ala Glu Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala
                725                 730                 735     
Glu Gly Thr Val Asp Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg
            740                 745                 750         
Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys
        755                 760                 765             
Leu Ser Gly Lys Glu Gln Ser Phe Thr Ser Leu Glu Val Arg Lys Val
    770                 775                 780                 
Ala Glu Thr Lys Glu Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys
785                 790                 795                 800 
Lys Val Gln Asp Gly Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys
                805                 810                 815     
Asp Gln Ser Asp Glu Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys
            820                 825                 830         
Gly Thr Glu Glu Lys Lys Lys Pro Ser Asp Phe Lys Lys Lys Val Ile
        835                 840                 845             
Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser Asp Gly Thr Glu Lys Leu
    850                 855                 860                 
Pro Glu Arg Glu Glu Ile Cys His Phe Pro Lys Gly Ile Lys Gln Ile
865                 870                 875                 880 
Lys Asn Gly Thr Thr Asp Gly Glu Lys Lys Ser Lys Lys Ile Arg Asp
                885                 890                 895     
Lys Thr Ser Lys Lys Lys Asp Glu Leu Ser Asp Tyr Ala Glu Lys Ser
            900                 905                 910         
Thr Gly Lys Gly Asp Ser Cys Asp Ser Ser Glu Asp Lys Lys Ser Lys
        915                 920                 925             
Asn Gly Ala Tyr Gly Arg Glu Lys Lys Arg Cys Lys Leu Leu Gly Lys
    930                 935                 940                 
Ser Ser Arg Lys Arg Gln Asp Cys Ser Ser Ser Asp Thr Glu Lys Tyr
945                 950                 955                 960 
Ser Met Lys Glu Asp Gly Cys Asn Ser Ser Asp Lys Arg Leu Lys Arg
                965                 970                 975     
Ile Glu Leu Arg Glu Arg Arg Asn Leu Ser Ser Lys Arg Asn Thr Lys
            980                 985                 990         
Glu Ile Gln Ser Gly Ser Ser Ser Ser Asp Ala Glu Glu Ser Ser Glu
        995                 1000                1005            
Asp Asn Lys Lys Lys Lys Gln Arg Thr Ser Ser Lys Lys Lys Ala Val
    1010                1015                1020                
Ile Val Lys Glu Lys Lys Arg Asn Ser Leu Arg Thr Ser Thr Lys Arg
1025                1030                1035                1040
Lys Gln Ala Asp Ile Thr Ser Ser Ser Ser Ser Asp Ile Glu Asp Asp
                1045                1050                1055    
Asp Gln Asn Ser Ile Gly Glu Gly Ser Ser Asp Glu Gln Lys Ile Lys
            1060                1065                1070        
Pro Val Thr Glu Asn Leu Val Leu Ser Ser His Thr Gly Phe Cys Gln
        1075                1080                1085            
Ser Ser Gly Asp Glu Ala Leu Ser Lys Ser Val Pro Val Thr Val Asp
    1090                1095                1100                
Asp Asp Asp Asp Asp Asn Asp Pro Glu Asn Arg Ile Ala Lys Lys Met
1105                1110                1115                1120
Leu Leu Glu Glu Ile Lys Ala Asn Leu Ser Ser Asp Glu Asp Gly Ser
                1125                1130                1135    
Ser Asp Asp Glu Pro Glu Glu Gly Lys Lys Arg Thr Gly Lys Gln Asn
            1140                1145                1150        
Glu Glu Asn Pro Gly Asp Glu Glu Ala Lys Asn Gln Val Asn Ser Glu
        1155                1160                1165            
Ser Asp Ser Asp Ser Glu Glu Ser Lys Lys Pro Arg Tyr Arg His Arg
    1170                1175                1180                
Leu Leu Arg His Lys Leu Thr Val Ser Asp Gly Glu Ser Gly Glu Glu
1185                1190                1195                1200
Lys Lys Thr Lys Pro Lys Glu His Lys Glu Val Lys Gly Arg Asn Arg
                1205                1210                1215    
Arg Lys Val Ser Ser Glu Asp Ser Glu Asp Ser Asp Phe Gln Glu Ser
            1220                1225                1230        
Gly Val Ser Glu Glu Val Ser Glu Ser Glu Asp Glu Gln Arg Pro Arg
        1235                1240                1245            
Thr Arg Ser Ala Lys Lys Ala Glu Leu Glu Glu Asn Gln Arg Ser Tyr
    1250                1255                1260                
Lys Gln Lys Lys Lys Arg Arg Arg Ile Lys Val Gln Glu Asp Ser Ser
1265                1270                1275                1280
Ser Glu Asn Lys Ser Asn Ser Glu Glu Glu Glu Glu Glu Lys Glu Glu
                1285                1290                1295    
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asn
            1300                1305                1310        
Asp Asp Ser Lys Ser Pro Gly Lys Gly Arg Lys Lys Ile Arg Lys Ile
        1315                1320                1325            
Leu Lys Asp Asp Lys Leu Arg Thr Glu Thr Gln Asn Ala Leu Lys Glu
    1330                1335                1340                
Glu Glu Glu Arg Arg Lys Arg Ile Ala Glu Arg Glu Arg Glu Arg Glu
1345                1350                1355                1360
Lys Leu Arg Glu Val Ile Glu Ile Glu Asp Ala Ser Pro Thr Lys Cys
                1365                1370                1375    
Pro Ile Thr Thr Lys Leu Val Leu Asp Glu Asp Glu Glu Thr Lys Glu
            1380                1385                1390        
Pro Leu Val Gln Val His Arg Asn Met Val Ile Lys Leu Lys Pro His
        1395                1400                1405            
Gln Val Asp Gly Val Gln Phe Met Trp Asp Cys Cys Cys Glu Ser Val
    1410                1415                1420                
Lys Lys Thr Lys Lys Ser Pro Gly Ser Gly Cys Ile Leu Ala His Cys
1425                1430                1435                1440
Met Gly Leu Gly Lys Thr Leu Gln Val Val Ser Phe Leu His Thr Val
                1445                1450                1455    
Leu Leu Cys Asp Lys Leu Asp Phe Ser Thr Ala Leu Val Val Cys Pro
            1460                1465                1470        
Leu Asn Thr Ala Leu Asn Trp Met Asn Glu Phe Glu Lys Trp Gln Glu
        1475                1480                1485            
Gly Leu Lys Asp Asp Glu Lys Leu Glu Val Ser Glu Leu Ala Thr Val
    1490                1495                1500                
Lys Arg Pro Gln Glu Arg Ser Tyr Met Leu Gln Arg Trp Gln Glu Asp
1505                1510                1515                1520
Gly Gly Val Met Ile Ile Gly Tyr Glu Met Tyr Arg Asn Leu Ala Gln
                1525                1530                1535    
Gly Arg Asn Val Lys Ser Arg Lys Leu Lys Glu Ile Phe Asn Lys Ala
            1540                1545                1550        
Leu Val Asp Pro Gly Pro Asp Phe Val Val Cys Asp Glu Gly His Ile
        1555                1560                1565            
Leu Lys Asn Glu Ala Ser Ala Val Ser Lys Ala Met Asn Ser Ile Arg
    1570                1575                1580                
Ser Arg Arg Arg Ile Ile Leu Thr Gly Thr Pro Leu Gln Asn Asn Leu
1585                1590                1595                1600
Ile Glu Tyr His Cys Met Val Asn Phe Ile Lys Glu Asn Leu Leu Gly
                1605                1610                1615    
Ser Ile Lys Glu Phe Arg Asn Arg Phe Ile Asn Pro Ile Gln Asn Gly
            1620                1625                1630        
Gln Cys Ala Asp Ser Thr Met Val Asp Val Arg Val Met Lys Lys Arg
        1635                1640                1645            
Ala His Ile Leu Tyr Glu Met Leu Ala Gly Cys Val Gln Arg Lys Asp
    1650                1655                1660                
Tyr Thr Ala Leu Thr Lys Phe Leu Pro Pro Lys His Glu Tyr Val Leu
1665                1670                1675                1680
Ala Val Arg Met Thr Ser Ile Gln Cys Lys Leu Tyr Gln Tyr Tyr Leu
                1685                1690                1695    
Asp His Leu Thr Gly Val Gly Asn Asn Ser Glu Gly Gly Arg Gly Lys
            1700                1705                1710        
Ala Gly Ala Lys Leu Phe Gln Asp Phe Gln Met Leu Ser Arg Ile Trp
        1715                1720                1725            
Thr His Pro Trp Cys Leu Gln Leu Asp Tyr Ile Ser Lys Glu Asn Lys
    1730                1735                1740                
Gly Tyr Phe Asp Glu Asp Ser Met Asp Glu Phe Ile Ala Ser Asp Ser
1745                1750                1755                1760
Asp Glu Thr Ser Met Ser Leu Ser Ser Asp Asp Tyr Thr Lys Lys Lys
                1765                1770                1775    
Lys Lys Gly Lys Lys Gly Lys Lys Asp Ser Ser Ser Ser Gly Ser Gly
            1780                1785                1790        
Ser Asp Asn Asp Val Glu Val Ile Lys Val Trp Asn Ser Arg Ser Arg
        1795                1800                1805            
Gly Gly Gly Glu Gly Asn Val Asp Glu Thr Gly Asn Asn Pro Ser Val
    1810                1815                1820                
Ser Leu Lys Leu Glu Glu Ser Lys Ala Thr Ser Ser Ser Asn Pro Ser
1825                1830                1835                1840
Ser Pro Ala Pro Asp Trp Tyr Lys Asp Phe Val Thr Asp Ala Asp Ala
                1845                1850                1855    
Glu Val Leu Glu His Ser Gly Lys Met Val Leu Leu Phe Glu Ile Leu
            1860                1865                1870        
Arg Met Ala Glu Glu Ile Gly Asp Lys Val Leu Val Phe Ser Gln Ser
        1875                1880                1885            
Leu Ile Ser Leu Asp Leu Ile Glu Asp Phe Leu Glu Leu Ala Ser Arg
    1890                1895                1900                
Glu Lys Thr Glu Asp Lys Asp Lys Pro Leu Ile Tyr Lys Gly Glu Gly
1905                1910                1915                1920
Lys Trp Leu Arg Asn Ile Asp Tyr Tyr Arg Leu Asp Gly Ser Thr Thr
                1925                1930                1935    
Ala Gln Ser Arg Lys Lys Trp Ala Glu Glu Phe Asn Asp Glu Thr Asn
            1940                1945                1950        
Val Arg Gly Arg Leu Phe Ile Ile Ser Thr Lys Ala Gly Ser Leu Gly
        1955                1960                1965            
Ile Asn Leu Val Ala Ala Asn Arg Val Ile Ile Phe Asp Ala Ser Trp
    1970                1975                1980                
Asn Pro Ser Tyr Asp Ile Gln Ser Ile Phe Arg Val Tyr Arg Phe Gly
1985                1990                1995                2000
Gln Thr Lys Pro Val Tyr Val Tyr Arg Phe Leu Ala Gln Gly Thr Met
                2005                2010                2015    
Glu Asp Lys Ile Tyr Asp Arg Gln Val Thr Lys Gln Ser Leu Ser Phe
            2020                2025                2030        
Arg Val Val Asp Gln Gln Gln Val Glu Arg His Phe Thr Met Asn Glu
        2035                2040                2045            
Leu Thr Glu Leu Tyr Thr Phe Glu Pro Asp Leu Leu Asp Asp Pro Asn
    2050                2055                2060                
Ser Glu Lys Lys Lys Lys Arg Asp Thr Pro Met Leu Pro Lys Asp Thr
2065                2070                2075                2080
Ile Leu Ala Glu Leu Leu Gln Ile His Lys Glu His Ile Val Gly Tyr
                2085                2090                2095    
His Glu His Asp Ser Leu Leu Asp His Lys Glu Glu Glu Glu Leu Thr
            2100                2105                2110        
Glu Glu Glu Arg Lys Ala Ala Trp Ala Glu Tyr Glu Ala Glu Lys Lys
        2115                2120                2125            
Val Leu Thr Met Arg Phe Asn Ile Pro Thr Gly Thr Asn Leu Pro Pro
    2130                2135                2140                
Val Ser Phe Asn Ser Gln Thr Pro Tyr Ile Pro Phe Asn Leu Gly Ala
2145                2150                2155                2160
Leu Ser Ala Met Ser Asn Gln Gln Leu Glu Asp Leu Ile Asn Gln Gly
                2165                2170                2175    
Arg Glu Lys Val Val Glu Ala Thr Asn Ser Val Thr Ala Val Arg Ile
            2180                2185                2190        
Gln Pro Leu Glu Asp Ile Ile Ser Ala Val Trp Lys Glu Asn Met Asn
        2195                2200                2205            
Leu Ser Glu Ala Gln Val Gln Ala Leu Ala Leu Ser Arg Gln Ala Ser
    2210                2215                2220                
Gln Glu Leu Asp Val Lys Arg Arg Glu Ala Ile Tyr Asn Asp Val Leu
2225                2230                2235                2240
Thr Lys Gln Gln Met Leu Ile Ser Cys Val Gln Arg Ile Leu Met Asn
                2245                2250                2255    
Arg Arg Leu Gln Gln Gln Tyr Asn Gln Gln Gln Gln Gln Gln Met Thr
            2260                2265                2270        
Tyr Gln Gln Ala Thr Leu Gly His Leu Met Met Pro Lys Pro Pro Asn
        2275                2280                2285            
Leu Ile Met Asn Pro Ser Asn Tyr Gln Gln Ile Asp Met Arg Gly Met
    2290                2295                2300                
Tyr Gln Pro Val Ala Gly Gly Met Gln Pro Pro Pro Leu Gln Arg Ala
2305                2310                2315                2320
Pro Pro Pro Met Arg Ser Lys Asn Pro Gly Pro Ser Gln Gly Lys Ser
                2325                2330                2335    
Met
    


<210> 8356
<211> 2454
<212> PRT
<213> Homo sapiens

<400> 8356
Met Thr Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Thr Leu Val Gln
 1               5                  10                  15      
Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Thr
            20                  25                  30          
Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Thr Asp Lys Ile Ser
        35                  40                  45              
Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly
    50                  55                  60                  
Thr Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys
65                  70                  75                  80  
Arg Lys Pro Ser Ile Val Thr Lys Tyr Val Glu Ser Asp Asp Glu Lys
                85                  90                  95      
Pro Leu Asp Asp Glu Thr Val Asn Glu Asp Ala Ser Asn Glu Asn Ser
            100                 105                 110         
Glu Asn Asp Ile Thr Met Gln Ser Leu Pro Lys Glu Asp Gly Leu His
        115                 120                 125             
Gly Ile Val Ser Cys Thr Ala Cys Gly Gln Gln Val Asn His Phe Gln
    130                 135                 140                 
Lys Asp Ser Ile Tyr Arg His Pro Ser Leu Gln Val Leu Ile Cys Lys
145                 150                 155                 160 
Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser Asp
                165                 170                 175     
Gly Met Asp Glu Gln Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu Ile
            180                 185                 190         
Cys Cys Asp Phe Cys His Asn Ala Phe Cys Lys Lys Cys Ile Leu Arg
        195                 200                 205             
Asn Leu Gly Arg Lys Glu Leu Ser Thr Ile Met Asp Glu Asn Asn Gln
    210                 215                 220                 
Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro Leu Leu Asp Leu Val Thr
225                 230                 235                 240 
Ala Cys Asn Ser Val Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln Asn
                245                 250                 255     
Lys Lys Lys Ile Lys Val Asp Ser Glu Lys Ser Asn Lys Val Tyr Glu
            260                 265                 270         
His Thr Ser Arg Phe Ser Pro Lys Lys Thr Ser Ser Asn Cys Asn Gly
        275                 280                 285             
Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser Gly Ser Val Thr Tyr Ser
    290                 295                 300                 
Tyr Ser Ala Leu Ile Val Pro Lys Glu Met Ile Lys Lys Ala Lys Lys
305                 310                 315                 320 
Leu Ile Glu Thr Thr Ala Asn Met Asn Ser Ser Tyr Val Lys Phe Leu
                325                 330                 335     
Lys Gln Ala Thr Asp Asn Ser Glu Ile Ser Ser Ala Thr Lys Leu Arg
            340                 345                 350         
Gln Leu Lys Ala Phe Lys Ser Val Leu Ala Asp Ile Lys Lys Ala His
        355                 360                 365             
Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu Phe Arg Ala Met Asp Ala
    370                 375                 380                 
Val Asn Lys Glu Lys Asn Thr Lys Glu His Lys Val Ile Asp Ala Lys
385                 390                 395                 400 
Phe Glu Thr Lys Ala Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu Lys
                405                 410                 415     
Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu Ser Arg Lys Gln Val Asp
            420                 425                 430         
Ser Glu His Met His Gln Asn Val Pro Thr Glu Glu Gln Arg Thr Asn
        435                 440                 445             
Lys Ser Thr Gly Gly Glu His Lys Lys Ser Asp Arg Lys Glu Glu Pro
    450                 455                 460                 
Gln Tyr Glu Pro Ala Asn Thr Ser Glu Asp Leu Asp Met Asp Ile Val
465                 470                 475                 480 
Ser Val Pro Ser Ser Val Pro Glu Asp Ile Phe Glu Asn Leu Glu Thr
                485                 490                 495     
Ala Met Glu Val Gln Ser Ser Val Asp His Gln Gly Asp Gly Ser Ser
            500                 505                 510         
Gly Thr Glu Gln Glu Val Glu Ser Ser Ser Val Lys Leu Asn Ile Ser
        515                 520                 525             
Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser Lys Thr Thr Ala Lys Val
    530                 535                 540                 
Thr Lys Glu Leu Tyr Val Lys Leu Thr Pro Val Ser Leu Pro Asn Ser
545                 550                 555                 560 
Pro Ile Lys Gly Ala Asp Cys Gln Glu Val Pro Gln Asp Lys Asp Gly
                565                 570                 575     
Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu Glu Lys Cys Gly Leu Gly
            580                 585                 590         
Gln Glu Asn Ser Asp Asn Glu His Leu Val Glu Asn Glu Val Ser Leu
        595                 600                 605             
Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser Pro Arg Val Lys Thr Thr
    610                 615                 620                 
Pro Leu Arg Arg Pro Thr Glu Thr Asn Pro Val Thr Ser Asn Ser Asp
625                 630                 635                 640 
Glu Glu Cys Asn Glu Thr Val Lys Glu Lys Gln Lys Leu Ser Val Pro
                645                 650                 655     
Val Arg Lys Lys Asp Lys Arg Asn Ser Ser Asp Ser Ala Ile Asp Asn
            660                 665                 670         
Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys Gln Ser Glu Thr Val Asp
        675                 680                 685             
Gln Asn Ser Asp Ser Asp Glu Met Leu Ala Ile Leu Lys Gly Val Ser
    690                 695                 700                 
Arg Met Ser His Ser Ser Ser Ser Asp Thr Asp Ile Asn Glu Ile His
705                 710                 715                 720 
Thr Asn His Lys Thr Leu Tyr Asp Leu Lys Thr Gln Ala Gly Lys Asp
                725                 730                 735     
Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser Thr Ser Gly Ser Asp Phe
            740                 745                 750         
Asp Thr Lys Lys Gly Lys Ser Ala Lys Ser Ser Ile Ile Ser Lys Lys
        755                 760                 765             
Lys Arg Gln Thr Gln Ser Glu Ser Ser Asn Tyr Asp Ser Glu Leu Glu
    770                 775                 780                 
Lys Glu Ile Lys Ser Met Ser Lys Ile Gly Ala Ala Arg Thr Thr Lys
785                 790                 795                 800 
Lys Arg Ile Pro Asn Thr Lys Asp Phe Asp Ser Ser Glu Asp Glu Lys
                805                 810                 815     
His Ser Lys Lys Gly Met Asp Asn Gln Gly His Lys Asn Leu Lys Thr
            820                 825                 830         
Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu Arg Lys Gln Glu Arg Glu
        835                 840                 845             
Thr Phe Ser Ser Ala Glu Gly Thr Val Asp Lys Asp Thr Thr Ile Met
    850                 855                 860                 
Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser Thr
865                 870                 875                 880 
Asp Gly Val Asp Lys Leu Ser Gly Lys Glu Gln Ser Phe Thr Ser Leu
                885                 890                 895     
Glu Val Arg Lys Val Ala Glu Thr Lys Glu Lys Ser Lys His Leu Lys
            900                 905                 910         
Thr Lys Thr Cys Lys Lys Val Gln Asp Gly Leu Ser Asp Ile Ala Glu
        915                 920                 925             
Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu Thr Ser Glu Asp Asp Lys
    930                 935                 940                 
Lys Gln Ser Lys Lys Gly Thr Glu Glu Lys Lys Lys Pro Ser Asp Phe
945                 950                 955                 960 
Lys Lys Lys Val Ile Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser Asp
                965                 970                 975     
Gly Thr Glu Lys Leu Pro Glu Arg Glu Glu Ile Cys His Phe Pro Lys
            980                 985                 990         
Gly Ile Lys Gln Ile Lys Asn Gly Thr Thr Asp Gly Glu Lys Lys Ser
        995                 1000                1005            
Lys Lys Ile Arg Asp Lys Thr Ser Lys Lys Lys Asp Glu Leu Ser Asp
    1010                1015                1020                
Tyr Ala Glu Lys Ser Thr Gly Lys Gly Asp Ser Cys Asp Ser Ser Glu
1025                1030                1035                1040
Asp Lys Lys Ser Lys Asn Gly Ala Tyr Gly Arg Glu Lys Lys Arg Cys
                1045                1050                1055    
Lys Leu Leu Gly Lys Ser Ser Arg Lys Arg Gln Asp Cys Ser Ser Ser
            1060                1065                1070        
Asp Thr Glu Lys Tyr Ser Met Lys Glu Asp Gly Cys Asn Ser Ser Asp
        1075                1080                1085            
Lys Arg Leu Lys Arg Ile Glu Leu Arg Glu Arg Arg Asn Leu Ser Ser
    1090                1095                1100                
Lys Arg Asn Thr Lys Glu Ile Gln Ser Gly Ser Ser Ser Ser Asp Ala
1105                1110                1115                1120
Glu Glu Ser Ser Glu Asp Asn Lys Lys Lys Lys Gln Arg Thr Ser Ser
                1125                1130                1135    
Lys Lys Lys Ala Val Ile Val Lys Glu Lys Lys Arg Asn Ser Leu Arg
            1140                1145                1150        
Thr Ser Thr Lys Arg Lys Gln Ala Asp Ile Thr Ser Ser Ser Ser Ser
        1155                1160                1165            
Asp Ile Glu Asp Asp Asp Gln Asn Ser Ile Gly Glu Gly Ser Ser Asp
    1170                1175                1180                
Glu Gln Lys Ile Lys Pro Val Thr Glu Asn Leu Val Leu Ser Ser His
1185                1190                1195                1200
Thr Gly Phe Cys Gln Ser Ser Gly Asp Glu Ala Leu Ser Lys Ser Val
                1205                1210                1215    
Pro Val Thr Val Asp Asp Asp Asp Asp Asp Asn Asp Pro Glu Asn Arg
            1220                1225                1230        
Ile Ala Lys Lys Met Leu Leu Glu Glu Ile Lys Ala Asn Leu Ser Ser
        1235                1240                1245            
Asp Glu Asp Gly Ser Ser Asp Asp Glu Pro Glu Glu Gly Lys Lys Arg
    1250                1255                1260                
Thr Gly Lys Gln Asn Glu Glu Asn Pro Gly Asp Glu Glu Ala Lys Asn
1265                1270                1275                1280
Gln Val Asn Ser Glu Ser Asp Ser Asp Ser Glu Glu Ser Lys Lys Pro
                1285                1290                1295    
Arg Tyr Arg His Arg Leu Leu Arg His Lys Leu Thr Val Ser Asp Gly
            1300                1305                1310        
Glu Ser Gly Glu Glu Lys Lys Thr Lys Pro Lys Glu His Lys Glu Val
        1315                1320                1325            
Lys Gly Arg Asn Arg Arg Lys Val Ser Ser Glu Asp Ser Glu Asp Ser
    1330                1335                1340                
Asp Phe Gln Glu Ser Gly Val Ser Glu Glu Val Ser Glu Ser Glu Asp
1345                1350                1355                1360
Glu Gln Arg Pro Arg Thr Arg Ser Ala Lys Lys Ala Glu Leu Glu Glu
                1365                1370                1375    
Asn Gln Arg Ser Tyr Lys Gln Lys Lys Lys Arg Arg Arg Ile Lys Val
            1380                1385                1390        
Gln Glu Asp Ser Ser Ser Glu Asn Lys Ser Asn Ser Glu Glu Glu Glu
        1395                1400                1405            
Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    1410                1415                1420                
Glu Glu Asp Glu Asn Asp Asp Ser Lys Ser Pro Gly Lys Gly Arg Lys
1425                1430                1435                1440
Lys Ile Arg Lys Ile Leu Lys Asp Asp Lys Leu Arg Thr Glu Thr Gln
                1445                1450                1455    
Asn Ala Leu Lys Glu Glu Glu Glu Arg Arg Lys Arg Ile Ala Glu Arg
            1460                1465                1470        
Glu Arg Glu Arg Glu Lys Leu Arg Glu Val Ile Glu Ile Glu Asp Ala
        1475                1480                1485            
Ser Pro Thr Lys Cys Pro Ile Thr Thr Lys Leu Val Leu Asp Glu Asp
    1490                1495                1500                
Glu Glu Thr Lys Glu Pro Leu Val Gln Val His Arg Asn Met Val Ile
1505                1510                1515                1520
Lys Leu Lys Pro His Gln Val Asp Gly Val Gln Phe Met Trp Asp Cys
                1525                1530                1535    
Cys Cys Glu Ser Val Lys Lys Thr Lys Lys Ser Pro Gly Ser Gly Cys
            1540                1545                1550        
Ile Leu Ala His Cys Met Gly Leu Gly Lys Thr Leu Gln Val Val Ser
        1555                1560                1565            
Phe Leu His Thr Val Leu Leu Cys Asp Lys Leu Asp Phe Ser Thr Ala
    1570                1575                1580                
Leu Val Val Cys Pro Leu Asn Thr Ala Leu Asn Trp Met Asn Glu Phe
1585                1590                1595                1600
Glu Lys Trp Gln Glu Gly Leu Lys Asp Asp Glu Lys Leu Glu Val Ser
                1605                1610                1615    
Glu Leu Ala Thr Val Lys Arg Pro Gln Glu Arg Ser Tyr Met Leu Gln
            1620                1625                1630        
Arg Trp Gln Glu Asp Gly Gly Val Met Ile Ile Gly Tyr Glu Met Tyr
        1635                1640                1645            
Arg Asn Leu Ala Gln Gly Arg Asn Val Lys Ser Arg Lys Leu Lys Glu
    1650                1655                1660                
Ile Phe Asn Lys Ala Leu Val Asp Pro Gly Pro Asp Phe Val Val Cys
1665                1670                1675                1680
Asp Glu Gly His Ile Leu Lys Asn Glu Ala Ser Ala Val Ser Lys Ala
                1685                1690                1695    
Met Asn Ser Ile Arg Ser Arg Arg Arg Ile Ile Leu Thr Gly Thr Pro
            1700                1705                1710        
Leu Gln Asn Asn Leu Ile Glu Tyr His Cys Met Val Asn Phe Ile Lys
        1715                1720                1725            
Glu Asn Leu Leu Gly Ser Ile Lys Glu Phe Arg Asn Arg Phe Ile Asn
    1730                1735                1740                
Pro Ile Gln Asn Gly Gln Cys Ala Asp Ser Thr Met Val Asp Val Arg
1745                1750                1755                1760
Val Met Lys Lys Arg Ala His Ile Leu Tyr Glu Met Leu Ala Gly Cys
                1765                1770                1775    
Val Gln Arg Lys Asp Tyr Thr Ala Leu Thr Lys Phe Leu Pro Pro Lys
            1780                1785                1790        
His Glu Tyr Val Leu Ala Val Arg Met Thr Ser Ile Gln Cys Lys Leu
        1795                1800                1805            
Tyr Gln Tyr Tyr Leu Asp His Leu Thr Gly Val Gly Asn Asn Ser Glu
    1810                1815                1820                
Gly Gly Arg Gly Lys Ala Gly Ala Lys Leu Phe Gln Asp Phe Gln Met
1825                1830                1835                1840
Leu Ser Arg Ile Trp Thr His Pro Trp Cys Leu Gln Leu Asp Tyr Ile
                1845                1850                1855    
Ser Lys Glu Asn Lys Gly Tyr Phe Asp Glu Asp Ser Met Asp Glu Phe
            1860                1865                1870        
Ile Ala Ser Asp Ser Asp Glu Thr Ser Met Ser Leu Ser Ser Asp Asp
        1875                1880                1885            
Tyr Thr Lys Lys Lys Lys Lys Gly Lys Lys Gly Lys Lys Asp Ser Ser
    1890                1895                1900                
Ser Ser Gly Ser Gly Ser Asp Asn Asp Val Glu Val Ile Lys Val Trp
1905                1910                1915                1920
Asn Ser Arg Ser Arg Gly Gly Gly Glu Gly Asn Val Asp Glu Thr Gly
                1925                1930                1935    
Asn Asn Pro Ser Val Ser Leu Lys Leu Glu Glu Ser Lys Ala Thr Ser
            1940                1945                1950        
Ser Ser Asn Pro Ser Ser Pro Ala Pro Asp Trp Tyr Lys Asp Phe Val
        1955                1960                1965            
Thr Asp Ala Asp Ala Glu Val Leu Glu His Ser Gly Lys Met Val Leu
    1970                1975                1980                
Leu Phe Glu Ile Leu Arg Met Ala Glu Glu Ile Gly Asp Lys Val Leu
1985                1990                1995                2000
Val Phe Ser Gln Ser Leu Ile Ser Leu Asp Leu Ile Glu Asp Phe Leu
                2005                2010                2015    
Glu Leu Ala Ser Arg Glu Lys Thr Glu Asp Lys Asp Lys Pro Leu Ile
            2020                2025                2030        
Tyr Lys Gly Glu Gly Lys Trp Leu Arg Asn Ile Asp Tyr Tyr Arg Leu
        2035                2040                2045            
Asp Gly Ser Thr Thr Ala Gln Ser Arg Lys Lys Trp Ala Glu Glu Phe
    2050                2055                2060                
Asn Asp Glu Thr Asn Val Arg Gly Arg Leu Phe Ile Ile Ser Thr Lys
2065                2070                2075                2080
Ala Gly Ser Leu Gly Ile Asn Leu Val Ala Ala Asn Arg Val Ile Ile
                2085                2090                2095    
Phe Asp Ala Ser Trp Asn Pro Ser Tyr Asp Ile Gln Ser Ile Phe Arg
            2100                2105                2110        
Val Tyr Arg Phe Gly Gln Thr Lys Pro Val Tyr Val Tyr Arg Phe Leu
        2115                2120                2125            
Ala Gln Gly Thr Met Glu Asp Lys Ile Tyr Asp Arg Gln Val Thr Lys
    2130                2135                2140                
Gln Ser Leu Ser Phe Arg Val Val Asp Gln Gln Gln Val Glu Arg His
2145                2150                2155                2160
Phe Thr Met Asn Glu Leu Thr Glu Leu Tyr Thr Phe Glu Pro Asp Leu
                2165                2170                2175    
Leu Asp Asp Pro Asn Ser Glu Lys Lys Lys Lys Arg Asp Thr Pro Met
            2180                2185                2190        
Leu Pro Lys Asp Thr Ile Leu Ala Glu Leu Leu Gln Ile His Lys Glu
        2195                2200                2205            
His Ile Val Gly Tyr His Glu His Asp Ser Leu Leu Asp His Lys Glu
    2210                2215                2220                
Glu Glu Glu Leu Thr Glu Glu Glu Arg Lys Ala Ala Trp Ala Glu Tyr
2225                2230                2235                2240
Glu Ala Glu Lys Lys Val Leu Thr Met Arg Phe Asn Ile Pro Thr Gly
                2245                2250                2255    
Thr Asn Leu Pro Pro Val Ser Phe Asn Ser Gln Thr Pro Tyr Ile Pro
            2260                2265                2270        
Phe Asn Leu Gly Ala Leu Ser Ala Met Ser Asn Gln Gln Leu Glu Asp
        2275                2280                2285            
Leu Ile Asn Gln Gly Arg Glu Lys Val Val Glu Ala Thr Asn Ser Val
    2290                2295                2300                
Thr Ala Val Arg Ile Gln Pro Leu Glu Asp Ile Ile Ser Ala Val Trp
2305                2310                2315                2320
Lys Glu Asn Met Asn Leu Ser Glu Ala Gln Val Gln Ala Leu Ala Leu
                2325                2330                2335    
Ser Arg Gln Ala Ser Gln Glu Leu Asp Val Lys Arg Arg Glu Ala Ile
            2340                2345                2350        
Tyr Asn Asp Val Leu Thr Lys Gln Gln Met Leu Ile Ser Cys Val Gln
        2355                2360                2365            
Arg Ile Leu Met Asn Arg Arg Leu Gln Gln Gln Tyr Asn Gln Gln Gln
    2370                2375                2380                
Gln Gln Gln Met Thr Tyr Gln Gln Ala Thr Leu Gly His Leu Met Met
2385                2390                2395                2400
Pro Lys Pro Pro Asn Leu Ile Met Asn Pro Ser Asn Tyr Gln Gln Ile
                2405                2410                2415    
Asp Met Arg Gly Met Tyr Gln Pro Val Ala Gly Gly Met Gln Pro Pro
            2420                2425                2430        
Pro Leu Gln Arg Ala Pro Pro Pro Met Arg Ser Lys Asn Pro Gly Pro
        2435                2440                2445            
Ser Gln Gly Lys Ser Met
    2450                


<210> 8357
<211> 2375
<212> PRT
<213> Homo sapiens

<400> 8357
Met Gln Ser Leu Pro Lys Gly Thr Val Ile Val Gln Pro Glu Pro Val
 1               5                  10                  15      
Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro Glu Phe Arg Ser Arg
            20                  25                  30          
Ser Lys Met Lys Thr Glu Asn Leu Lys Lys Arg Gly Glu Asp Gly Leu
        35                  40                  45              
His Gly Ile Val Ser Cys Thr Ala Cys Gly Gln Gln Val Asn His Phe
    50                  55                  60                  
Gln Lys Asp Ser Ile Tyr Arg His Pro Ser Leu Gln Val Leu Ile Cys
65                  70                  75                  80  
Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser
                85                  90                  95      
Asp Gly Met Asp Glu Gln Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu
            100                 105                 110         
Ile Cys Cys Asp Phe Cys His Asn Ala Phe Cys Lys Lys Cys Ile Leu
        115                 120                 125             
Arg Asn Leu Gly Arg Lys Glu Leu Ser Thr Ile Met Asp Glu Asn Asn
    130                 135                 140                 
Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro Leu Leu Asp Leu Val
145                 150                 155                 160 
Thr Ala Cys Asn Ser Val Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln
                165                 170                 175     
Asn Lys Lys Lys Ile Lys Val Asp Ser Glu Lys Ser Asn Lys Val Tyr
            180                 185                 190         
Glu His Thr Ser Arg Phe Ser Pro Lys Lys Thr Ser Ser Asn Cys Asn
        195                 200                 205             
Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser Gly Ser Val Thr Tyr
    210                 215                 220                 
Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu Met Ile Lys Lys Ala Lys
225                 230                 235                 240 
Lys Leu Ile Glu Thr Thr Ala Asn Met Asn Ser Ser Tyr Val Lys Phe
                245                 250                 255     
Leu Lys Gln Ala Thr Asp Asn Ser Glu Ile Ser Ser Ala Thr Lys Leu
            260                 265                 270         
Arg Gln Leu Lys Ala Phe Lys Ser Val Leu Ala Asp Ile Lys Lys Ala
        275                 280                 285             
His Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu Phe Arg Ala Met Asp
    290                 295                 300                 
Ala Val Asn Lys Glu Lys Asn Thr Lys Glu His Lys Val Ile Asp Ala
305                 310                 315                 320 
Lys Phe Glu Thr Lys Ala Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu
                325                 330                 335     
Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu Ser Arg Lys Gln Val
            340                 345                 350         
Asp Ser Glu His Met His Gln Asn Val Pro Thr Glu Glu Gln Arg Thr
        355                 360                 365             
Asn Lys Ser Thr Gly Gly Glu His Lys Lys Ser Asp Arg Lys Glu Glu
    370                 375                 380                 
Pro Gln Tyr Glu Pro Ala Asn Thr Ser Glu Asp Leu Asp Met Asp Ile
385                 390                 395                 400 
Val Ser Val Pro Ser Ser Val Pro Glu Asp Ile Phe Glu Asn Leu Glu
                405                 410                 415     
Thr Ala Met Glu Val Gln Ser Ser Val Asp His Gln Gly Asp Gly Ser
            420                 425                 430         
Ser Gly Thr Glu Gln Glu Val Glu Ser Ser Ser Val Lys Leu Asn Ile
        435                 440                 445             
Ser Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser Lys Thr Thr Ala Lys
    450                 455                 460                 
Val Thr Lys Glu Leu Tyr Val Lys Leu Thr Pro Val Ser Leu Pro Asn
465                 470                 475                 480 
Ser Pro Ile Lys Gly Ala Asp Cys Gln Glu Val Pro Gln Asp Lys Asp
                485                 490                 495     
Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu Glu Lys Cys Gly Leu
            500                 505                 510         
Gly Gln Glu Asn Ser Asp Asn Glu His Leu Val Glu Asn Glu Val Ser
        515                 520                 525             
Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser Pro Arg Val Lys Thr
    530                 535                 540                 
Thr Pro Leu Arg Arg Pro Thr Glu Thr Asn Pro Val Thr Ser Asn Ser
545                 550                 555                 560 
Asp Glu Glu Cys Asn Glu Thr Val Lys Glu Lys Gln Lys Leu Ser Val
                565                 570                 575     
Pro Val Arg Lys Lys Asp Lys Arg Asn Ser Ser Asp Ser Ala Ile Asp
            580                 585                 590         
Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys Gln Ser Glu Thr Val
        595                 600                 605             
Asp Gln Asn Ser Asp Ser Asp Glu Met Leu Ala Ile Leu Lys Gly Val
    610                 615                 620                 
Ser Arg Met Ser His Ser Ser Ser Ser Asp Thr Asp Ile Asn Glu Ile
625                 630                 635                 640 
His Thr Asn His Lys Thr Leu Tyr Asp Leu Lys Thr Gln Ala Gly Lys
                645                 650                 655     
Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser Thr Ser Gly Ser Asp
            660                 665                 670         
Phe Asp Thr Lys Lys Gly Lys Ser Ala Lys Ser Ser Ile Ile Ser Lys
        675                 680                 685             
Lys Lys Arg Gln Thr Gln Ser Glu Ser Ser Asn Tyr Asp Ser Glu Leu
    690                 695                 700                 
Glu Lys Glu Ile Lys Ser Met Ser Lys Ile Gly Ala Ala Arg Thr Thr
705                 710                 715                 720 
Lys Lys Arg Ile Pro Asn Thr Lys Asp Phe Asp Ser Ser Glu Asp Glu
                725                 730                 735     
Lys His Ser Lys Lys Gly Met Asp Asn Gln Gly His Lys Asn Leu Lys
            740                 745                 750         
Thr Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu Arg Lys Gln Glu Arg
        755                 760                 765             
Glu Thr Phe Ser Ser Ala Glu Gly Thr Val Asp Lys Asp Thr Thr Ile
    770                 775                 780                 
Met Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser
785                 790                 795                 800 
Thr Asp Gly Val Asp Lys Leu Ser Gly Lys Glu Gln Ser Phe Thr Ser
                805                 810                 815     
Leu Glu Val Arg Lys Val Ala Glu Thr Lys Glu Lys Ser Lys His Leu
            820                 825                 830         
Lys Thr Lys Thr Cys Lys Lys Val Gln Asp Gly Leu Ser Asp Ile Ala
        835                 840                 845             
Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu Thr Ser Glu Asp Asp
    850                 855                 860                 
Lys Lys Gln Ser Lys Lys Gly Thr Glu Glu Lys Lys Lys Pro Ser Asp
865                 870                 875                 880 
Phe Lys Lys Lys Val Ile Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser
                885                 890                 895     
Asp Gly Thr Glu Lys Leu Pro Glu Arg Glu Glu Ile Cys His Phe Pro
            900                 905                 910         
Lys Gly Ile Lys Gln Ile Lys Asn Gly Thr Thr Asp Gly Glu Lys Lys
        915                 920                 925             
Ser Lys Lys Ile Arg Asp Lys Thr Ser Lys Lys Lys Asp Glu Leu Ser
    930                 935                 940                 
Asp Tyr Ala Glu Lys Ser Thr Gly Lys Gly Asp Ser Cys Asp Ser Ser
945                 950                 955                 960 
Glu Asp Lys Lys Ser Lys Asn Gly Ala Tyr Gly Arg Glu Lys Lys Arg
                965                 970                 975     
Cys Lys Leu Leu Gly Lys Ser Ser Arg Lys Arg Gln Asp Cys Ser Ser
            980                 985                 990         
Ser Asp Thr Glu Lys Tyr Ser Met Lys Glu Asp Gly Cys Asn Ser Ser
        995                 1000                1005            
Asp Lys Arg Leu Lys Arg Ile Glu Leu Arg Glu Arg Arg Asn Leu Ser
    1010                1015                1020                
Ser Lys Arg Asn Thr Lys Glu Ile Gln Ser Gly Ser Ser Ser Ser Asp
1025                1030                1035                1040
Ala Glu Glu Ser Ser Glu Asp Asn Lys Lys Lys Lys Gln Arg Thr Ser
                1045                1050                1055    
Ser Lys Lys Lys Ala Val Ile Val Lys Glu Lys Lys Arg Asn Ser Leu
            1060                1065                1070        
Arg Thr Ser Thr Lys Arg Lys Gln Ala Asp Ile Thr Ser Ser Ser Ser
        1075                1080                1085            
Ser Asp Ile Glu Asp Asp Asp Gln Asn Ser Ile Gly Glu Gly Ser Ser
    1090                1095                1100                
Asp Glu Gln Lys Ile Lys Pro Val Thr Glu Asn Leu Val Leu Ser Ser
1105                1110                1115                1120
His Thr Gly Phe Cys Gln Ser Ser Gly Asp Glu Ala Leu Ser Lys Ser
                1125                1130                1135    
Val Pro Val Thr Val Asp Asp Asp Asp Asp Asp Asn Asp Pro Glu Asn
            1140                1145                1150        
Arg Ile Ala Lys Lys Met Leu Leu Glu Glu Ile Lys Ala Asn Leu Ser
        1155                1160                1165            
Ser Asp Glu Asp Gly Ser Ser Asp Asp Glu Pro Glu Glu Gly Lys Lys
    1170                1175                1180                
Arg Thr Gly Lys Gln Asn Glu Glu Asn Pro Gly Asp Glu Glu Ala Lys
1185                1190                1195                1200
Asn Gln Val Asn Ser Glu Ser Asp Ser Asp Ser Glu Glu Ser Lys Lys
                1205                1210                1215    
Pro Arg Tyr Arg His Arg Leu Leu Arg His Lys Leu Thr Val Ser Asp
            1220                1225                1230        
Gly Glu Ser Gly Glu Glu Lys Lys Thr Lys Pro Lys Glu His Lys Glu
        1235                1240                1245            
Val Lys Gly Arg Asn Arg Arg Lys Val Ser Ser Glu Asp Ser Glu Asp
    1250                1255                1260                
Ser Asp Phe Gln Glu Ser Gly Val Ser Glu Glu Val Ser Glu Ser Glu
1265                1270                1275                1280
Asp Glu Gln Arg Pro Arg Thr Arg Ser Ala Lys Lys Ala Glu Leu Glu
                1285                1290                1295    
Glu Asn Gln Arg Ser Tyr Lys Gln Lys Lys Lys Arg Arg Arg Ile Lys
            1300                1305                1310        
Val Gln Glu Asp Ser Ser Ser Glu Asn Lys Ser Asn Ser Glu Glu Glu
        1315                1320                1325            
Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    1330                1335                1340                
Glu Glu Glu Asp Glu Asn Asp Asp Ser Lys Ser Pro Gly Lys Gly Arg
1345                1350                1355                1360
Lys Lys Ile Arg Lys Ile Leu Lys Asp Asp Lys Leu Arg Thr Glu Thr
                1365                1370                1375    
Gln Asn Ala Leu Lys Glu Glu Glu Glu Arg Arg Lys Arg Ile Ala Glu
            1380                1385                1390        
Arg Glu Arg Glu Arg Glu Lys Leu Arg Glu Val Ile Glu Ile Glu Asp
        1395                1400                1405            
Ala Ser Pro Thr Lys Cys Pro Ile Thr Thr Lys Leu Val Leu Asp Glu
    1410                1415                1420                
Asp Glu Glu Thr Lys Glu Pro Leu Val Gln Val His Arg Asn Met Val
1425                1430                1435                1440
Ile Lys Leu Lys Pro His Gln Val Asp Gly Val Gln Phe Met Trp Asp
                1445                1450                1455    
Cys Cys Cys Glu Ser Val Lys Lys Thr Lys Lys Ser Pro Gly Ser Gly
            1460                1465                1470        
Cys Ile Leu Ala His Cys Met Gly Leu Gly Lys Thr Leu Gln Val Val
        1475                1480                1485            
Ser Phe Leu His Thr Val Leu Leu Cys Asp Lys Leu Asp Phe Ser Thr
    1490                1495                1500                
Ala Leu Val Val Cys Pro Leu Asn Thr Ala Leu Asn Trp Met Asn Glu
1505                1510                1515                1520
Phe Glu Lys Trp Gln Glu Gly Leu Lys Asp Asp Glu Lys Leu Glu Val
                1525                1530                1535    
Ser Glu Leu Ala Thr Val Lys Arg Pro Gln Glu Arg Ser Tyr Met Leu
            1540                1545                1550        
Gln Arg Trp Gln Glu Asp Gly Gly Val Met Ile Ile Gly Tyr Glu Met
        1555                1560                1565            
Tyr Arg Asn Leu Ala Gln Gly Arg Asn Val Lys Ser Arg Lys Leu Lys
    1570                1575                1580                
Glu Ile Phe Asn Lys Ala Leu Val Asp Pro Gly Pro Asp Phe Val Val
1585                1590                1595                1600
Cys Asp Glu Gly His Ile Leu Lys Asn Glu Ala Ser Ala Val Ser Lys
                1605                1610                1615    
Ala Met Asn Ser Ile Arg Ser Arg Arg Arg Ile Ile Leu Thr Gly Thr
            1620                1625                1630        
Pro Leu Gln Asn Asn Leu Ile Glu Tyr His Cys Met Val Asn Phe Ile
        1635                1640                1645            
Lys Glu Asn Leu Leu Gly Ser Ile Lys Glu Phe Arg Asn Arg Phe Ile
    1650                1655                1660                
Asn Pro Ile Gln Asn Gly Gln Cys Ala Asp Ser Thr Met Val Asp Val
1665                1670                1675                1680
Arg Val Met Lys Lys Arg Ala His Ile Leu Tyr Glu Met Leu Ala Gly
                1685                1690                1695    
Cys Val Gln Arg Lys Asp Tyr Thr Ala Leu Thr Lys Phe Leu Pro Pro
            1700                1705                1710        
Lys His Glu Tyr Val Leu Ala Val Arg Met Thr Ser Ile Gln Cys Lys
        1715                1720                1725            
Leu Tyr Gln Tyr Tyr Leu Asp His Leu Thr Gly Val Gly Asn Asn Ser
    1730                1735                1740                
Glu Gly Gly Arg Gly Lys Ala Gly Ala Lys Leu Phe Gln Asp Phe Gln
1745                1750                1755                1760
Met Leu Ser Arg Ile Trp Thr His Pro Trp Cys Leu Gln Leu Asp Tyr
                1765                1770                1775    
Ile Ser Lys Glu Asn Lys Gly Tyr Phe Asp Glu Asp Ser Met Asp Glu
            1780                1785                1790        
Phe Ile Ala Ser Asp Ser Asp Glu Thr Ser Met Ser Leu Ser Ser Asp
        1795                1800                1805            
Asp Tyr Thr Lys Lys Lys Lys Lys Gly Lys Lys Gly Lys Lys Asp Ser
    1810                1815                1820                
Ser Ser Ser Gly Ser Gly Ser Asp Asn Asp Val Glu Val Ile Lys Val
1825                1830                1835                1840
Trp Asn Ser Arg Ser Arg Gly Gly Gly Glu Gly Asn Val Asp Glu Thr
                1845                1850                1855    
Gly Asn Asn Pro Ser Val Ser Leu Lys Leu Glu Glu Ser Lys Ala Thr
            1860                1865                1870        
Ser Ser Ser Asn Pro Ser Ser Pro Ala Pro Asp Trp Tyr Lys Asp Phe
        1875                1880                1885            
Val Thr Asp Ala Asp Ala Glu Val Leu Glu His Ser Gly Lys Met Val
    1890                1895                1900                
Leu Leu Phe Glu Ile Leu Arg Met Ala Glu Glu Ile Gly Asp Lys Val
1905                1910                1915                1920
Leu Val Phe Ser Gln Ser Leu Ile Ser Leu Asp Leu Ile Glu Asp Phe
                1925                1930                1935    
Leu Glu Leu Ala Ser Arg Glu Lys Thr Glu Asp Lys Asp Lys Pro Leu
            1940                1945                1950        
Ile Tyr Lys Gly Glu Gly Lys Trp Leu Arg Asn Ile Asp Tyr Tyr Arg
        1955                1960                1965            
Leu Asp Gly Ser Thr Thr Ala Gln Ser Arg Lys Lys Trp Ala Glu Glu
    1970                1975                1980                
Phe Asn Asp Glu Thr Asn Val Arg Gly Arg Leu Phe Ile Ile Ser Thr
1985                1990                1995                2000
Lys Ala Gly Ser Leu Gly Ile Asn Leu Val Ala Ala Asn Arg Val Ile
                2005                2010                2015    
Ile Phe Asp Ala Ser Trp Asn Pro Ser Tyr Asp Ile Gln Ser Ile Phe
            2020                2025                2030        
Arg Val Tyr Arg Phe Gly Gln Thr Lys Pro Val Tyr Val Tyr Arg Phe
        2035                2040                2045            
Leu Ala Gln Gly Thr Met Glu Asp Lys Ile Tyr Asp Arg Gln Val Thr
    2050                2055                2060                
Lys Gln Ser Leu Ser Phe Arg Val Val Asp Gln Gln Gln Val Glu Arg
2065                2070                2075                2080
His Phe Thr Met Asn Glu Leu Thr Glu Leu Tyr Thr Phe Glu Pro Asp
                2085                2090                2095    
Leu Leu Asp Asp Pro Asn Ser Glu Lys Lys Lys Lys Arg Asp Thr Pro
            2100                2105                2110        
Met Leu Pro Lys Asp Thr Ile Leu Ala Glu Leu Leu Gln Ile His Lys
        2115                2120                2125            
Glu His Ile Val Gly Tyr His Glu His Asp Ser Leu Leu Asp His Lys
    2130                2135                2140                
Glu Glu Glu Glu Leu Thr Glu Glu Glu Arg Lys Ala Ala Trp Ala Glu
2145                2150                2155                2160
Tyr Glu Ala Glu Lys Lys Val Leu Thr Met Arg Phe Asn Ile Pro Thr
                2165                2170                2175    
Gly Thr Asn Leu Pro Pro Val Ser Phe Asn Ser Gln Thr Pro Tyr Ile
            2180                2185                2190        
Pro Phe Asn Leu Gly Ala Leu Ser Ala Met Ser Asn Gln Gln Leu Glu
        2195                2200                2205            
Asp Leu Ile Asn Gln Gly Arg Glu Lys Val Val Glu Ala Thr Asn Ser
    2210                2215                2220                
Val Thr Ala Val Arg Ile Gln Pro Leu Glu Asp Ile Ile Ser Ala Val
2225                2230                2235                2240
Trp Lys Glu Asn Met Asn Leu Ser Glu Ala Gln Val Gln Ala Leu Ala
                2245                2250                2255    
Leu Ser Arg Gln Ala Ser Gln Glu Leu Asp Val Lys Arg Arg Glu Ala
            2260                2265                2270        
Ile Tyr Asn Asp Val Leu Thr Lys Gln Gln Met Leu Ile Ser Cys Val
        2275                2280                2285            
Gln Arg Ile Leu Met Asn Arg Arg Leu Gln Gln Gln Tyr Asn Gln Gln
    2290                2295                2300                
Gln Gln Gln Gln Met Thr Tyr Gln Gln Ala Thr Leu Gly His Leu Met
2305                2310                2315                2320
Met Pro Lys Pro Pro Asn Leu Ile Met Asn Pro Ser Asn Tyr Gln Gln
                2325                2330                2335    
Ile Asp Met Arg Gly Met Tyr Gln Pro Val Ala Gly Gly Met Gln Pro
            2340                2345                2350        
Pro Pro Leu Gln Arg Ala Pro Pro Pro Met Arg Ser Lys Asn Pro Gly
        2355                2360                2365            
Pro Ser Gln Gly Lys Ser Met
    2370                2375


<210> 8358
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 8358
Met Ala Arg Asn Cys Ser Glu Cys Lys Glu Lys Arg Ala Ala His Ile
 1               5                  10                  15      
Leu Cys Thr Tyr Cys Asn Arg Trp Leu Cys Ser Ser Cys Thr Glu Glu
            20                  25                  30          
His Arg His Ser Pro Val Pro Gly Gly Pro Phe Phe Pro Arg Ala Gln
        35                  40                  45              
Lys Gly Ser Pro Gly Val Asn Gly Gly Pro Gly Asp Phe Thr Leu Tyr
    50                  55                  60                  
Cys Pro Leu His Thr Gln Glu Val Leu Lys Leu Phe Cys Glu Thr Cys
65                  70                  75                  80  
Asp Met Leu Thr Cys His Ser Cys Leu Val Val Glu His Lys Glu His
                85                  90                  95      
Arg His Val Glu Glu Val Leu Gln Asn Gln Arg Met Leu Leu Glu Gly
            100                 105                 110         
Val Thr Thr Gln Val Ala His Lys Lys Ser Ser Leu Gln Thr Ser Ala
        115                 120                 125             
Lys Gln Ile Glu Asp Arg Ile Phe Glu Val Lys His Gln His Arg Lys
    130                 135                 140                 
Val Glu Asn Gln Ile Lys Met Ala Lys Met Val Leu Met Asn Glu Leu
145                 150                 155                 160 
Asn Lys Gln Ala Asn Gly Leu Ile Glu Glu Leu Glu Gly Ile Thr Asn
                165                 170                 175     
Glu Arg Lys Arg Lys Leu Glu Gln Gln Leu Gln Ser Ile Met Val Leu
            180                 185                 190         
Asn Arg Gln Phe Glu His Val Gln Asn Phe Ile Asn Trp Ala Val Cys
        195                 200                 205             
Ser Lys Thr Ser Val Pro Phe Leu Phe Ser Lys Glu Leu Ile Val Phe
    210                 215                 220                 
Gln Met Gln Arg Leu Leu Glu Thr Ser Cys Asn Thr Asp Pro Gly Ser
225                 230                 235                 240 
Pro Trp Ser Ile Arg Phe Thr Trp Glu Pro Asn Phe Trp Thr Lys Gln
                245                 250                 255     
Leu Ala Ser Leu Gly Cys Ile Thr Thr Glu Gly Gly Gln Met Ser Arg
            260                 265                 270         
Ala Asp Ala Pro Ala Tyr Gly Gly Leu Gln Gly Ser Ser Pro Phe Tyr
        275                 280                 285             
Gln Ser His Gln Ser Pro Val Ala Gln Gln Glu Ala Leu Ser His Pro
    290                 295                 300                 
Ser His Lys Phe Gln Ser Pro Ala Val Cys Ser Ser Ser Val Cys Cys
305                 310                 315                 320 
Ser His Cys Ser Pro Val Ser Pro Ser Leu Lys Gly Gln Val Pro Pro
                325                 330                 335     
Pro Ser Ile His Pro Ala His Ser Phe Arg Gln Pro Pro Glu Met Val
            340                 345                 350         
Pro Gln Gln Leu Gly Ser Leu Gln Cys Ser Ala Leu Leu Pro Arg Glu
        355                 360                 365             
Lys Glu Leu Ala Cys Ser Pro His Pro Pro Lys Leu Leu Gln Pro Trp
    370                 375                 380                 
Leu Glu Thr Gln Pro Pro Val Glu Gln Glu Ser Thr Ser Gln Arg Leu
385                 390                 395                 400 
Gly Gln Gln Leu Thr Ser Gln Pro Val Cys Ile Val Pro Pro Gln Asp
                405                 410                 415     
Val Gln Gln Gly Ala His Ala Gln Pro Thr Leu Gln Thr Pro Ser Ile
            420                 425                 430         
Gln Val Gln Phe Gly His His Gln Lys Leu Lys Leu Ser His Phe Gln
        435                 440                 445             
Gln Gln Pro Gln Gln Gln Leu Pro Pro Pro Pro Pro Pro Leu Pro His
    450                 455                 460                 
Pro Pro Pro Pro Leu Pro Pro Pro Pro Gln Gln Pro His Pro Pro Leu
465                 470                 475                 480 
Pro Pro Ser Gln His Leu Ala Ser Ser Gln His Glu Ser Pro Pro Gly
                485                 490                 495     
Pro Ala Cys Ser Gln Asn Met Asp Ile Met His His Lys Phe Glu Leu
            500                 505                 510         
Glu Glu Met Gln Lys Asp Leu Glu Leu Leu Leu Gln Ala Gln Gln Pro
        515                 520                 525             
Ser Leu Gln Leu Ser Gln Thr Lys Ser Pro Gln His Leu Gln Gln Thr
    530                 535                 540                 
Ile Val Gly Gln Ile Asn Tyr Ile Val Arg Gln Pro Ala Pro Val Gln
545                 550                 555                 560 
Ser Gln Ser Gln Glu Glu Thr Leu Gln Ala Thr Asp Glu Pro Pro Ala
                565                 570                 575     
Ser Gln Gly Ser Lys Pro Ala Leu Pro Leu Asp Lys Asn Thr Ala Ala
            580                 585                 590         
Ala Leu Pro Gln Ala Ser Gly Glu Glu Thr Pro Leu Ser Val Pro Pro
        595                 600                 605             
Val Asp Ser Thr Ile Gln His Ser Ser Pro Asn Val Val Arg Lys His
    610                 615                 620                 
Ser Thr Ser Leu Ser Ile Met Gly Phe Ser Asn Thr Leu Glu Met Glu
625                 630                 635                 640 
Leu Ser Ser Thr Arg Leu Glu Arg Pro Leu Glu Pro Gln Ile Gln Ser
                645                 650                 655     
Val Ser Asn Leu Thr Ala Gly Ala Pro Gln Ala Val Pro Ser Leu Leu
            660                 665                 670         
Ser Ala Pro Pro Lys Met Val Ser Ser Leu Thr Ser Val Gln Asn Gln
        675                 680                 685             
Ala Met Pro Ser Leu Thr Thr Ser His Leu Gln Thr Val Pro Ser Leu
    690                 695                 700                 
Val His Ser Thr Phe Gln Ser Met Pro Asn Leu Ile Ser Asp Ser Pro
705                 710                 715                 720 
Gln Ala Met Ala Ser Leu Ala Ser Asp His Pro Gln Ala Gly Pro Ser
                725                 730                 735     
Leu Met Ser Gly His Thr Gln Ala Val Pro Ser Leu Ala Thr Cys Pro
            740                 745                 750         
Leu Gln Ser Ile Pro Pro Val Ser Asp Met Gln Pro Glu Thr Gly Ser
        755                 760                 765             
Ser Ser Ser Ser Gly Arg Thr Ser Gly Ser Leu Cys Pro Arg Asp Gly
    770                 775                 780                 
Ala Asp Pro Ser Leu Glu Asn Ala Leu Cys Lys Val Lys Leu Glu Glu
785                 790                 795                 800 
Pro Ile Asn Leu Ser Val Lys Lys Pro Pro Leu Ala Pro Val Val Ser
                805                 810                 815     
Thr Ser Thr Ala Leu Gln Gln Tyr Gln Asn Pro Lys Glu Cys Glu Asn
            820                 825                 830         
Phe Glu Gln Gly Ala Leu Glu Leu Asp Ala Lys Glu Asn Gln Ser Ile
        835                 840                 845             
Arg Ala Phe Asn Ser Glu His Lys Ile Pro Tyr Val Arg Leu Glu Arg
    850                 855                 860                 
Leu Lys Ile Cys Ala Ala Ser Ser Gly Glu Met Pro Val Phe Lys Leu
865                 870                 875                 880 
Lys Pro Gln Lys Asn Asp Gln Asp Gly Ser Phe Leu Leu Ile Ile Glu
                885                 890                 895     
Cys Gly Thr Glu Ser Ser Ser Met Ser Ile Lys Val Ser Gln Asp Arg
            900                 905                 910         
Leu Ser Glu Ala Thr Gln Ala Pro Gly Leu Glu Gly Arg Lys Val Thr
        915                 920                 925             
Val Thr Ser Leu Ala Gly Gln Arg Pro Pro Glu Val Glu Gly Thr Ser
    930                 935                 940                 
Pro Glu Glu His Arg Leu Ile Pro Arg Thr Pro Gly Ala Lys Lys Gly
945                 950                 955                 960 
Pro Pro Ala Pro Ile Glu Asn Glu Asp Phe Cys Ala Val Cys Leu Asn
                965                 970                 975     
Gly Gly Glu Leu Leu Cys Cys Asp Arg Cys Pro Lys Val Phe His Leu
            980                 985                 990         
Ser Cys His Val Pro Ala Leu Leu Ser Phe Pro Gly Gly Glu Trp Val
        995                 1000                1005            
Cys Thr Leu Cys Arg Ser Leu Thr Gln Pro Glu Met Glu Tyr Asp Cys
    1010                1015                1020                
Glu Asn Ala Cys Tyr Asn Gln Pro Gly Met Arg Ala Ser Pro Gly Leu
1025                1030                1035                1040
Ser Met Tyr Asp Gln Lys Lys Cys Glu Lys Leu Val Leu Ser Leu Cys
                1045                1050                1055    
Cys Asn Asn Leu Ser Leu Pro Phe His Glu Pro Val Ser Pro Leu Ala
            1060                1065                1070        
Arg His Tyr Tyr Gln Ile Ile Lys Arg Pro Met Asp Leu Ser Ile Ile
        1075                1080                1085            
Arg Arg Lys Leu Gln Lys Lys Asp Pro Ala His Tyr Thr Thr Pro Glu
    1090                1095                1100                
Glu Val Val Ser Asp Val Arg Leu Met Phe Trp Asn Cys Ala Lys Phe
1105                1110                1115                1120
Asn Tyr Pro Asp Ser Glu Val Ala Glu Ala Gly Arg Cys Leu Glu Val
                1125                1130                1135    
Phe Phe Glu Gly Trp Leu Lys Glu Ile Tyr Pro Glu Lys Arg Phe Ala
            1140                1145                1150        
Gln Pro Arg Gln Glu Asp Ser Asp Ser Glu Glu Val Ser Ser Glu Ser
        1155                1160                1165            
Gly Cys Ser Thr Pro Gln Gly Phe Pro Trp Pro Pro Tyr Met Gln Glu
    1170                1175                1180                
Gly Ile Gln Pro Lys Arg Arg Arg Arg His Met Glu Asn Glu Arg Ala
1185                1190                1195                1200
Lys Arg Met Ser Phe Arg Leu Ala Asn Ser Ile Ser Gln Val
                1205                1210                


<210> 8359
<211> 1187
<212> PRT
<213> Homo sapiens

<400> 8359
Met Pro Phe Gly Leu Lys Leu Arg Arg Thr Arg Arg Tyr Asn Val Leu
 1               5                  10                  15      
Ser Lys Asn Cys Phe Val Thr Arg Ile Arg Leu Leu Asp Ser Asn Val
            20                  25                  30          
Ile Glu Cys Thr Leu Ser Val Glu Ser Thr Gly Gln Glu Cys Leu Glu
        35                  40                  45              
Ala Val Ala Gln Arg Leu Glu Leu Arg Glu Thr His Tyr Phe Gly Leu
    50                  55                  60                  
Trp Phe Leu Ser Lys Ser Gln Gln Ala Arg Trp Val Glu Leu Glu Lys
65                  70                  75                  80  
Pro Leu Lys Lys His Leu Asp Lys Phe Ala Asn Glu Pro Leu Leu Phe
                85                  90                  95      
Phe Gly Val Met Phe Tyr Val Pro Asn Val Ser Trp Leu Gln Gln Glu
            100                 105                 110         
Ala Thr Arg Tyr Gln Tyr Tyr Leu Gln Val Lys Lys Asp Val Leu Glu
        115                 120                 125             
Gly Arg Leu Arg Cys Thr Leu Asp Gln Val Ile Arg Leu Ala Gly Leu
    130                 135                 140                 
Ala Val Gln Ala Asp Phe Gly Asp Tyr Asn Gln Phe Asp Ser Gln Asp
145                 150                 155                 160 
Phe Leu Arg Glu Tyr Val Leu Phe Pro Met Asp Leu Ala Leu Glu Glu
                165                 170                 175     
Ala Val Leu Glu Glu Leu Thr Gln Lys Val Ala Gln Glu His Lys Ala
            180                 185                 190         
His Ser Gly Ile Leu Pro Ala Glu Ala Glu Leu Met Tyr Ile Asn Glu
        195                 200                 205             
Val Glu Arg Leu Asp Gly Phe Gly Gln Glu Ile Phe Pro Val Lys Asp
    210                 215                 220                 
Asn His Gly Asn Cys Val His Leu Gly Ile Phe Phe Met Gly Ile Phe
225                 230                 235                 240 
Val Arg Asn Arg Ile Gly Arg Gln Ala Val Ile Tyr Arg Trp Asn Asp
                245                 250                 255     
Met Gly Asn Ile Thr His Asn Lys Ser Thr Ile Leu Val Glu Leu Ile
            260                 265                 270         
Asn Lys Glu Glu Thr Ala Leu Phe His Thr Asp Asp Ile Glu Asn Ala
        275                 280                 285             
Lys Tyr Ile Ser Arg Leu Phe Ala Thr Arg His Lys Phe Tyr Lys Gln
    290                 295                 300                 
Asn Lys Ile Cys Thr Glu Gln Ser Asn Ser Pro Pro Pro Ile Arg Arg
305                 310                 315                 320 
Gln Pro Thr Trp Ser Arg Ser Ser Leu Pro Arg Gln Gln Pro Tyr Ile
                325                 330                 335     
Leu Pro Pro Val His Val Gln Cys Gly Glu His Tyr Ser Glu Thr His
            340                 345                 350         
Thr Ser Gln Asp Ser Ile Phe His Gly Asn Glu Glu Ala Leu Tyr Cys
        355                 360                 365             
Asn Ser His Asn Ser Leu Asp Leu Asn Tyr Leu Asn Gly Thr Val Thr
    370                 375                 380                 
Asn Gly Ser Val Cys Ser Val Asp Ser Val Asn Ser Leu Asn Cys Ser
385                 390                 395                 400 
Gln Ser Phe Ile Gln Ala Ser Pro Val Ser Ser Asn Leu Ser Ile Pro
                405                 410                 415     
Gly Ser Asp Ile Met Arg Ala Asp Tyr Ile Pro Ser His Arg His Ser
            420                 425                 430         
Ala Ile Ile Val Pro Ser Tyr Arg Pro Thr Pro Asp Tyr Glu Thr Val
        435                 440                 445             
Met Arg Gln Met Lys Arg Gly Ile Leu His Thr Asp Ser Gln Ser Gln
    450                 455                 460                 
Ser Leu Arg Asn Leu Asn Ile Ile Asn Thr His Ala Tyr Asn Gln Pro
465                 470                 475                 480 
Glu Asp Leu Val Tyr Ser Gln Pro Glu Met Arg Glu Arg His Pro Tyr
                485                 490                 495     
Thr Val Pro Tyr Gly Pro Gln Gly Val Tyr Ser Asn Lys Leu Val Ser
            500                 505                 510         
Pro Ser Asp Gln Arg Asn Pro Lys Asn Asn Val Val Pro Ser Lys Pro
        515                 520                 525             
Gly Ala Ser Ala Ile Ser His Thr Val Ser Thr Pro Glu Leu Ala Asn
    530                 535                 540                 
Met Gln Leu Gln Gly Ser His Asn Tyr Ser Thr Ala His Met Leu Lys
545                 550                 555                 560 
Asn Tyr Leu Phe Arg Pro Pro Pro Pro Tyr Pro Arg Pro Arg Pro Ala
                565                 570                 575     
Thr Ser Thr Pro Asp Leu Ala Ser His Arg His Lys Tyr Val Ser Gly
            580                 585                 590         
Ser Ser Pro Asp Leu Val Thr Arg Lys Val Gln Leu Ser Val Lys Thr
        595                 600                 605             
Phe Gln Glu Asp Ser Ser Pro Val Val His Gln Ser Leu Gln Glu Val
    610                 615                 620                 
Ser Glu Pro Leu Thr Ala Thr Lys His His Gly Thr Val Asn Lys Arg
625                 630                 635                 640 
His Ser Leu Glu Val Met Asn Ser Met Val Arg Gly Met Glu Ala Met
                645                 650                 655     
Thr Leu Lys Ser Leu His Leu Pro Met Ala Arg Arg Asn Thr Leu Arg
            660                 665                 670         
Glu Gln Gly Pro Pro Glu Glu Gly Ser Gly Ser His Glu Val Pro Gln
        675                 680                 685             
Leu Pro Gln Tyr His His Lys Lys Thr Phe Ser Asp Ala Thr Met Leu
    690                 695                 700                 
Ile His Ser Ser Glu Ser Glu Glu Glu Glu Glu Glu Ala Pro Glu Ser
705                 710                 715                 720 
Val Pro Gln Ile Pro Met Leu Arg Glu Lys Met Glu Tyr Ser Ala Gln
                725                 730                 735     
Leu Gln Ala Ala Leu Ala Arg Ile Pro Asn Lys Pro Pro Pro Glu Tyr
            740                 745                 750         
Pro Gly Pro Arg Lys Ser Val Ser Asn Gly Ala Leu Arg Gln Asp Gln
        755                 760                 765             
Ala Ser Leu Pro Pro Ala Met Ala Arg Ala Arg Val Leu Arg His Gly
    770                 775                 780                 
Pro Ala Lys Ala Ile Ser Met Ser Arg Thr Asp Pro Pro Ala Val Asn
785                 790                 795                 800 
Gly Ala Ser Leu Gly Pro Ser Ile Ser Glu Pro Asp Leu Thr Ser Val
                805                 810                 815     
Lys Glu Arg Val Lys Lys Glu Pro Val Lys Glu Arg Pro Val Ser Glu
            820                 825                 830         
Met Phe Ser Leu Glu Asp Ser Ile Ile Glu Arg Glu Met Met Ile Arg
        835                 840                 845             
Asn Leu Glu Lys Gln Lys Met Ala Gly Leu Glu Ala Gln Lys Arg Pro
    850                 855                 860                 
Leu Met Leu Ala Ala Leu Asn Gly Leu Ser Val Ala Arg Val Ser Gly
865                 870                 875                 880 
Arg Glu Glu Asn Arg Val Asp Ala Thr Arg Val Pro Met Asp Glu Arg
                885                 890                 895     
Phe Arg Thr Leu Lys Lys Lys Leu Glu Glu Gly Met Val Phe Thr Glu
            900                 905                 910         
Tyr Glu Gln Ile Pro Lys Lys Lys Ala Asn Gly Ile Phe Ser Thr Ala
        915                 920                 925             
Ala Leu Pro Glu Asn Ala Glu Arg Ser Arg Ile Arg Glu Val Val Pro
    930                 935                 940                 
Tyr Glu Glu Asn Arg Val Glu Leu Ile Pro Thr Lys Glu Asn Asn Thr
945                 950                 955                 960 
Gly Tyr Ile Asn Ala Ser His Ile Lys Val Val Val Gly Gly Ala Glu
                965                 970                 975     
Trp His Tyr Ile Ala Thr Gln Gly Pro Leu Pro His Thr Cys His Asp
            980                 985                 990         
Phe Trp Gln Met Val Trp Glu Gln Gly Val Asn Val Ile Ala Met Val
        995                 1000                1005            
Thr Ala Glu Glu Glu Gly Gly Arg Thr Lys Ser His Arg Tyr Trp Pro
    1010                1015                1020                
Lys Leu Gly Ser Lys His Ser Ser Ala Thr Tyr Gly Lys Phe Lys Val
1025                1030                1035                1040
Thr Thr Lys Phe Arg Thr Asp Ser Val Cys Tyr Ala Thr Thr Gly Leu
                1045                1050                1055    
Lys Val Lys His Leu Leu Ser Gly Gln Glu Arg Thr Val Trp His Leu
            1060                1065                1070        
Gln Tyr Thr Asp Trp Pro Asp His Gly Cys Pro Glu Asp Val Gln Gly
        1075                1080                1085            
Phe Leu Ser Tyr Leu Glu Glu Ile Gln Ser Val Arg Arg His Thr Asn
    1090                1095                1100                
Ser Met Leu Glu Gly Thr Lys Asn Arg His Pro Pro Ile Val Val His
1105                1110                1115                1120
Cys Ser Ala Gly Val Gly Arg Thr Gly Val Leu Ile Leu Ser Glu Leu
                1125                1130                1135    
Met Ile Tyr Cys Leu Glu His Asn Glu Lys Val Glu Val Pro Met Met
            1140                1145                1150        
Leu Arg Leu Leu Arg Glu Gln Arg Met Phe Met Ile Gln Thr Ile Ala
        1155                1160                1165            
Gln Tyr Lys Phe Val Tyr Gln Val Leu Ile Gln Phe Leu Gln Asn Ser
    1170                1175                1180                
Arg Leu Ile
1185        


<210> 8360
<211> 1174
<212> PRT
<213> Homo sapiens

<400> 8360
Met Pro Leu Pro Phe Gly Leu Lys Leu Lys Arg Thr Arg Arg Tyr Thr
 1               5                  10                  15      
Val Ser Ser Lys Ser Cys Leu Val Ala Arg Ile Gln Leu Leu Asn Asn
            20                  25                  30          
Glu Phe Val Glu Phe Thr Leu Ser Val Glu Ser Thr Gly Gln Glu Ser
        35                  40                  45              
Leu Glu Ala Val Ala Gln Arg Leu Glu Leu Arg Glu Val Thr Tyr Phe
    50                  55                  60                  
Ser Leu Trp Tyr Tyr Asn Lys Gln Asn Gln Arg Arg Trp Val Asp Leu
65                  70                  75                  80  
Glu Lys Pro Leu Lys Lys Gln Leu Asp Lys Tyr Ala Leu Glu Pro Thr
                85                  90                  95      
Val Tyr Phe Gly Val Val Phe Tyr Val Pro Ser Val Ser Gln Leu Gln
            100                 105                 110         
Gln Glu Ile Thr Arg Tyr Gln Tyr Tyr Leu Gln Leu Lys Lys Asp Ile
        115                 120                 125             
Leu Glu Gly Ser Ile Pro Cys Thr Leu Glu Gln Ala Ile Gln Leu Ala
    130                 135                 140                 
Gly Leu Ala Val Gln Ala Asp Phe Gly Asp Phe Asp Gln Tyr Glu Ser
145                 150                 155                 160 
Gln Asp Phe Leu Gln Lys Phe Ala Leu Phe Pro Val Gly Trp Leu Gln
                165                 170                 175     
Asp Glu Lys Val Leu Glu Glu Ala Thr Gln Lys Val Ala Leu Leu His
            180                 185                 190         
Gln Lys Tyr Arg Gly Leu Thr Ala Pro Asp Ala Glu Met Leu Tyr Met
        195                 200                 205             
Gln Glu Val Glu Arg Met Asp Gly Tyr Gly Glu Glu Ser Tyr Pro Ala
    210                 215                 220                 
Lys Asp Ser Gln Gly Ser Asp Ile Ser Ile Gly Ala Cys Leu Glu Gly
225                 230                 235                 240 
Ile Phe Val Lys His Lys Asn Gly Arg His Pro Val Val Phe Arg Trp
                245                 250                 255     
His Asp Ile Ala Asn Met Ser His Asn Lys Ser Phe Phe Ala Leu Glu
            260                 265                 270         
Leu Ala Asn Lys Glu Glu Thr Ile Gln Phe Gln Thr Glu Asp Met Glu
        275                 280                 285             
Thr Ala Lys Tyr Ile Trp Arg Leu Cys Val Ala Arg His Lys Phe Tyr
    290                 295                 300                 
Arg Leu Asn Gln Cys Asn Leu Gln Thr Gln Thr Val Thr Val Asn Pro
305                 310                 315                 320 
Ile Arg Arg Arg Ser Ser Ser Arg Met Ser Leu Pro Lys Pro Gln Pro
                325                 330                 335     
Tyr Val Met Pro Pro Pro Pro Gln Leu His Tyr Asn Gly His Tyr Thr
            340                 345                 350         
Glu Pro Tyr Ala Ser Ser Gln Asp Asn Leu Phe Val Pro Asn Gln Asn
        355                 360                 365             
Gly Tyr Tyr Cys His Ser Gln Thr Ser Leu Asp Arg Ala Gln Ile Asp
    370                 375                 380                 
Phe Asn Gly Arg Ile Arg Asn Gly Ser Val Tyr Ser Ala His Ser Thr
385                 390                 395                 400 
Asn Ser Leu Asn Asn Pro Gln Pro Tyr Leu Gln Pro Ser Pro Met Ser
                405                 410                 415     
Ser Asn Pro Ser Ile Thr Gly Ser Asp Val Met Arg Pro Asp Tyr Leu
            420                 425                 430         
Pro Ser His Arg His Ser Ala Val Ile Pro Pro Ser Tyr Arg Pro Thr
        435                 440                 445             
Pro Asp Tyr Glu Thr Val Met Lys Gln Leu Asn Arg Gly Leu Val His
    450                 455                 460                 
Ala Glu Arg Gln Ser His Ser Leu Arg Asn Leu Asn Ile Gly Ser Ser
465                 470                 475                 480 
Tyr Ala Tyr Ser Arg Pro Ala Ala Leu Val Tyr Ser Gln Pro Glu Ile
                485                 490                 495     
Arg Glu His Ala Gln Leu Pro Ser Pro Ala Ala Ala His Cys Pro Phe
            500                 505                 510         
Ser Leu Ser Tyr Ser Phe His Ser Pro Ser Pro Tyr Pro Tyr Pro Ala
        515                 520                 525             
Glu Arg Arg Pro Val Val Gly Ala Val Ser Val Pro Glu Leu Thr Asn
    530                 535                 540                 
Ala Gln Leu Gln Ala Gln Asp Tyr Pro Ser Pro Asn Ile Met Arg Thr
545                 550                 555                 560 
Gln Val Tyr Arg Pro Pro Pro Pro Tyr Pro Pro Pro Arg Pro Ala Asn
                565                 570                 575     
Ser Thr Pro Asp Leu Ser Arg His Leu Tyr Ile Ser Ser Ser Asn Pro
            580                 585                 590         
Asp Leu Ile Thr Arg Arg Val His His Ser Val Gln Thr Phe Gln Glu
        595                 600                 605             
Asp Ser Leu Pro Val Ala His Ser Leu Gln Glu Val Ser Glu Pro Leu
    610                 615                 620                 
Thr Ala Ala Arg His Ala Gln Leu His Lys Arg Asn Ser Ile Glu Val
625                 630                 635                 640 
Ala Gly Leu Ser His Gly Leu Glu Gly Leu Arg Leu Lys Glu Arg Thr
                645                 650                 655     
Leu Ser Ala Ser Ala Ala Glu Val Ala Pro Arg Ala Val Ser Val Gly
            660                 665                 670         
Ser Gln Pro Ser Val Phe Thr Glu Arg Thr Gln Arg Glu Gly Pro Glu
        675                 680                 685             
Glu Ala Glu Gly Leu Arg Tyr Gly His Lys Lys Ser Leu Ser Asp Ala
    690                 695                 700                 
Thr Met Leu Ile His Ser Ser Glu Glu Glu Glu Asp Glu Asp Phe Glu
705                 710                 715                 720 
Glu Glu Ser Gly Ala Arg Ala Pro Pro Ala Arg Ala Arg Glu Pro Arg
                725                 730                 735     
Pro Gly Leu Ala Gln Asp Pro Pro Gly Cys Pro Arg Val Leu Leu Ala
            740                 745                 750         
Gly Pro Leu His Ile Leu Glu Pro Lys Ala His Val Pro Asp Ala Glu
        755                 760                 765             
Lys Arg Met Met Asp Ser Ser Pro Val Arg Thr Thr Ala Glu Ala Gln
    770                 775                 780                 
Arg Pro Trp Arg Asp Gly Leu Leu Met Pro Ser Met Ser Glu Ser Asp
785                 790                 795                 800 
Leu Thr Thr Ser Gly Arg Tyr Arg Ala Arg Arg Asp Ser Leu Lys Lys
                805                 810                 815     
Arg Pro Val Ser Asp Leu Leu Ser Gly Lys Lys Asn Ile Val Glu Gly
            820                 825                 830         
Leu Pro Pro Leu Gly Gly Met Lys Lys Thr Arg Val Asp Ala Lys Lys
        835                 840                 845             
Ile Gly Pro Leu Lys Leu Ala Ala Leu Asn Gly Leu Ser Leu Ser Arg
    850                 855                 860                 
Val Pro Leu Pro Asp Glu Gly Lys Glu Val Ala Thr Arg Ala Thr Asn
865                 870                 875                 880 
Asp Glu Arg Cys Lys Ile Leu Glu Gln Arg Leu Glu Gln Gly Met Val
                885                 890                 895     
Phe Thr Glu Tyr Glu Arg Ile Leu Lys Lys Arg Leu Val Asp Gly Glu
            900                 905                 910         
Cys Ser Thr Ala Arg Leu Pro Glu Asn Ala Glu Arg Asn Arg Phe Gln
        915                 920                 925             
Asp Val Leu Pro Tyr Asp Asp Ala Arg Val Glu Leu Val Pro Thr Lys
    930                 935                 940                 
Glu Asn Asn Thr Gly Tyr Ile Asn Ala Ser His Ile Lys Val Ser Val
945                 950                 955                 960 
Ser Gly Ile Glu Trp Asp Tyr Ile Ala Thr Gln Gly Pro Leu Gln Asn
                965                 970                 975     
Thr Cys Gln Asp Phe Trp Gln Met Val Trp Glu Gln Gly Ile Ala Ile
            980                 985                 990         
Ile Ala Met Val Thr Ala Glu Glu Glu Gly Gly Arg Glu Lys Ser Phe
        995                 1000                1005            
Arg Tyr Trp Pro Arg Leu Gly Ser Arg His Asn Thr Val Thr Tyr Gly
    1010                1015                1020                
Arg Phe Lys Ile Thr Thr Arg Phe Arg Thr Asp Ser Gly Cys Tyr Ala
1025                1030                1035                1040
Thr Thr Gly Leu Lys Met Lys His Leu Leu Thr Gly Gln Glu Arg Thr
                1045                1050                1055    
Val Trp His Leu Gln Tyr Thr Asp Trp Pro Glu His Gly Cys Pro Glu
            1060                1065                1070        
Asp Leu Lys Gly Phe Leu Ser Tyr Leu Glu Glu Ile Gln Ser Val Arg
        1075                1080                1085            
Arg His Thr Asn Ser Thr Ser Asp Pro Gln Ser Pro Asn Pro Pro Leu
    1090                1095                1100                
Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Val Ile Leu
1105                1110                1115                1120
Ser Glu Ile Met Ile Ala Cys Leu Glu His Asn Glu Val Leu Asp Ile
                1125                1130                1135    
Pro Arg Val Leu Asp Met Leu Arg Gln Gln Arg Met Met Leu Val Gln
            1140                1145                1150        
Thr Leu Cys Gln Tyr Thr Phe Val Tyr Arg Val Leu Ile Gln Phe Leu
        1155                1160                1165            
Lys Ser Ser Arg Leu Ile
    1170                


<210> 8361
<211> 399
<212> PRT
<213> Homo sapiens

<400> 8361
Met Gln Ser Leu Ser Leu Gly Gln Thr Ser Ile Ser Lys Gly Leu Asn
 1               5                  10                  15      
Tyr Leu Thr Ile Met Ala Pro Gly Asn Leu Trp His Met Arg Asn Asn
            20                  25                  30          
Phe Leu Phe Gly Ser Arg Cys Trp Met Thr Arg Phe Ser Ala Glu Asn
        35                  40                  45              
Ile Phe Lys Ser Val Ser Phe Arg Leu Phe Gly Val Lys Cys His Asn
    50                  55                  60                  
Thr Asp Ser Glu Pro Leu Lys Asn Glu Asp Leu Leu Lys Asn Leu Leu
65                  70                  75                  80  
Thr Met Gly Val Asp Ile Asp Met Ala Arg Lys Arg Gln Pro Gly Val
                85                  90                  95      
Phe His Arg Met Ile Thr Asn Glu Gln Asp Leu Lys Met Phe Leu Leu
            100                 105                 110         
Ser Lys Gly Ala Ser Lys Glu Val Ile Ala Ser Ile Ile Ser Arg Tyr
        115                 120                 125             
Pro Arg Ala Ile Thr Arg Thr Pro Glu Asn Leu Ser Lys Arg Trp Asp
    130                 135                 140                 
Leu Trp Arg Lys Ile Val Thr Ser Asp Leu Glu Ile Val Asn Ile Leu
145                 150                 155                 160 
Glu Arg Ser Pro Glu Ser Phe Phe Arg Ser Asn Asn Asn Leu Asn Leu
                165                 170                 175     
Glu Asn Asn Ile Lys Phe Leu Tyr Ser Val Gly Leu Thr Arg Lys Cys
            180                 185                 190         
Leu Cys Arg Leu Leu Thr Asn Ala Pro Arg Thr Phe Ser Asn Ser Leu
        195                 200                 205             
Asp Leu Asn Lys Gln Met Val Glu Phe Leu Gln Ala Ala Gly Leu Ser
    210                 215                 220                 
Leu Gly His Asn Asp Pro Ala Asp Phe Val Arg Lys Ile Ile Phe Lys
225                 230                 235                 240 
Asn Pro Phe Ile Leu Ile Gln Ser Thr Lys Arg Val Lys Ala Asn Ile
                245                 250                 255     
Glu Phe Leu Arg Ser Thr Phe Asn Leu Asn Ser Glu Glu Leu Leu Val
            260                 265                 270         
Leu Ile Cys Gly Pro Gly Ala Glu Ile Leu Asp Leu Ser Asn Asp Tyr
        275                 280                 285             
Ala Arg Arg Ser Tyr Ala Asn Ile Lys Glu Lys Leu Phe Ser Leu Gly
    290                 295                 300                 
Cys Thr Glu Glu Glu Val Gln Lys Phe Val Leu Ser Tyr Pro Asp Val
305                 310                 315                 320 
Ile Phe Leu Ala Glu Lys Lys Phe Asn Asp Lys Ile Asp Cys Leu Met
                325                 330                 335     
Glu Glu Asn Ile Ser Ile Ser Gln Ile Ile Glu Asn Pro Arg Val Leu
            340                 345                 350         
Asp Ser Ser Ile Ser Thr Leu Lys Ser Arg Ile Lys Glu Leu Val Asn
        355                 360                 365             
Ala Gly Cys Asn Leu Ser Thr Leu Asn Ile Thr Leu Leu Ser Trp Ser
    370                 375                 380                 
Lys Lys Arg Tyr Glu Ala Lys Leu Lys Lys Leu Ser Arg Phe Ala
385                 390                 395                 


<210> 8362
<211> 424
<212> PRT
<213> Homo sapiens

<400> 8362
Met Glu Met Thr Thr Asn Lys Leu Lys Met Gln Leu Lys Ser Ala Gln
 1               5                  10                  15      
Ser Glu Leu Glu Gln Thr Arg Asn Thr Leu Lys Ser Met Glu Gly Ser
            20                  25                  30          
Asp Gly His Ala Met Lys Val Ala Met Gly Met Gln Lys Gln Ile Thr
        35                  40                  45              
Ala Lys Arg Gly Gln Ile Asp Ala Leu Gln Ser Lys Ile Gln Phe Leu
    50                  55                  60                  
Glu Glu Ala Met Thr Asn Ala Asn Lys Glu Lys His Phe Leu Lys Glu
65                  70                  75                  80  
Glu Lys Ser Lys Leu Ser Gln Glu Leu Ser Thr Val Ala Thr Glu Lys
                85                  90                  95      
Asn Lys Met Ala Gly Glu Leu Glu Val Leu Arg Ser Gln Glu Arg Arg
            100                 105                 110         
Leu Lys Glu Lys Val Thr Asn Met Glu Val Ala Leu Asp Lys Ala Ser
        115                 120                 125             
Leu Gln Phe Ala Glu Cys Gln Asp Ile Ile Gln Arg Gln Glu Gln Glu
    130                 135                 140                 
Ser Val Arg Leu Lys Leu Gln His Thr Leu Asp Ile Lys Glu Leu Gln
145                 150                 155                 160 
Gly Pro Gly Tyr Thr Ser Asn Ser Ser Leu Lys Pro Arg Leu Leu Gln
                165                 170                 175     
Pro Ala Ser Val Thr Arg Ser His Ser Asn Val Pro Ser Ser Gln Ser
            180                 185                 190         
Thr Ala Ser Phe Leu Ser His His Ser Thr Lys Ala Asn Thr Leu Lys
        195                 200                 205             
Glu Asp Pro Thr Arg Asp Leu Lys Gln Leu Leu Gln Glu Leu Arg Ser
    210                 215                 220                 
Val Ile Asn Glu Glu Pro Ala Val Ser Leu Ser Lys Thr Glu Glu Asp
225                 230                 235                 240 
Gly Arg Thr Ser Leu Gly Ala Leu Glu Asp Arg Val Arg Asp Cys Ile
                245                 250                 255     
Thr Glu Ser Ser Leu Arg Ser Asp Met Cys His Arg Ser Asn Asn Ser
            260                 265                 270         
Leu Arg Asp Ser Thr Glu Gly Ser Lys Ser Ser Glu Thr Leu Ser Arg
        275                 280                 285             
Glu Pro Val Thr Leu His Ala Gly Asp Arg Glu Asp Pro Ser Gly Cys
    290                 295                 300                 
Phe Thr Phe Thr Ser Ala Ala Ser Pro Ser Val Lys Asn Ser Ala Ser
305                 310                 315                 320 
Arg Ser Phe Asn Ser Ser Pro Lys Lys Ser Pro Val His Ser Leu Leu
                325                 330                 335     
Thr Ser Ser Val Glu Gly Ser Ile Gly Ser Thr Ser Gln Tyr Arg Ser
            340                 345                 350         
Ala Lys Pro Ile His Ser Ser Asp Ser Val Lys Asp Ser Gln Ser Pro
        355                 360                 365             
Pro Ile Glu Thr Thr Gly Lys Thr Cys Arg Lys Leu Gln Asn Arg Leu
    370                 375                 380                 
Glu Ser Leu Gln Thr Leu Val Glu Asp Leu Gln Leu Lys Asn Gln Ala
385                 390                 395                 400 
Met Ser Ser Met Ile Arg Asn Gln Glu Lys Arg Ile Gln Lys Val Lys
                405                 410                 415     
Asp Gln Glu Lys Met Leu Leu Lys
            420                 


<210> 8363
<211> 728
<212> PRT
<213> Homo sapiens

<400> 8363
Met Ser Glu Ser Gly Glu Met Ser Glu Phe Gly Tyr Ile Met Glu Leu
 1               5                  10                  15      
Ile Ala Lys Gly Lys Val Thr Ile Lys Asn Ile Glu Arg Glu Leu Ile
            20                  25                  30          
Cys Pro Ala Cys Lys Glu Leu Phe Thr His Pro Leu Ile Leu Pro Cys
        35                  40                  45              
Gln His Ser Ile Cys His Lys Cys Val Lys Glu Leu Leu Leu Thr Leu
    50                  55                  60                  
Asp Asp Ser Phe Asn Asp Val Gly Ser Asp Asn Ser Asn Gln Ser Ser
65                  70                  75                  80  
Pro Arg Leu Arg Leu Pro Ser Pro Ser Met Asp Lys Ile Asp Arg Ile
                85                  90                  95      
Asn Arg Pro Gly Trp Lys Arg Asn Ser Leu Thr Pro Arg Thr Thr Val
            100                 105                 110         
Phe Pro Cys Pro Gly Cys Glu His Asp Val Asp Leu Gly Glu Arg Gly
        115                 120                 125             
Ile Asn Gly Leu Phe Arg Asn Phe Thr Leu Glu Thr Ile Val Glu Arg
    130                 135                 140                 
Tyr Arg Gln Ala Ala Arg Ala Ala Thr Ala Ile Met Cys Asp Leu Cys
145                 150                 155                 160 
Lys Pro Pro Pro Gln Glu Ser Thr Lys Ser Cys Met Asp Cys Ser Ala
                165                 170                 175     
Ser Tyr Cys Asn Glu Cys Phe Lys Ile His His Pro Trp Gly Thr Ile
            180                 185                 190         
Lys Ala Gln His Glu Tyr Val Gly Pro Thr Thr Asn Phe Arg Pro Lys
        195                 200                 205             
Ile Leu Met Cys Pro Glu His Glu Thr Glu Arg Ile Asn Met Tyr Cys
    210                 215                 220                 
Glu Leu Cys Arg Arg Pro Val Cys His Leu Cys Lys Leu Gly Gly Asn
225                 230                 235                 240 
His Ala Asn His Arg Val Thr Thr Met Ser Ser Ala Tyr Lys Thr Leu
                245                 250                 255     
Lys Glu Lys Leu Ser Lys Asp Ile Asp Tyr Leu Ile Gly Lys Glu Ser
            260                 265                 270         
Gln Val Lys Ser Gln Ile Ser Glu Leu Asn Leu Leu Met Lys Glu Thr
        275                 280                 285             
Glu Cys Asn Gly Glu Arg Ala Lys Glu Glu Ala Ile Thr His Phe Glu
    290                 295                 300                 
Lys Leu Phe Glu Val Leu Glu Glu Arg Lys Ser Ser Val Leu Lys Ala
305                 310                 315                 320 
Ile Asp Ser Ser Lys Lys Leu Arg Leu Asp Lys Phe Gln Thr Gln Met
                325                 330                 335     
Glu Glu Tyr Gln Gly Leu Leu Glu Asn Asn Gly Leu Val Gly Tyr Ala
            340                 345                 350         
Gln Glu Val Leu Lys Glu Thr Asp Gln Ser Cys Phe Val Gln Thr Ala
        355                 360                 365             
Lys Gln Leu His Leu Arg Ile Gln Lys Ala Thr Glu Ser Leu Lys Ser
    370                 375                 380                 
Phe Arg Pro Ala Ala Gln Thr Ser Phe Glu Asp Tyr Val Val Asn Thr
385                 390                 395                 400 
Ser Lys Gln Thr Glu Leu Leu Gly Glu Leu Ser Phe Phe Ser Ser Gly
                405                 410                 415     
Ile Asp Val Pro Glu Ile Asn Glu Glu Gln Ser Lys Val Tyr Asn Asn
            420                 425                 430         
Ala Leu Ile Asn Trp His His Pro Glu Lys Asp Lys Ala Asp Ser Tyr
        435                 440                 445             
Val Leu Glu Tyr Arg Lys Ile Asn Arg Asp Asp Glu Met Ser Trp Asn
    450                 455                 460                 
Glu Ile Glu Val Cys Gly Thr Ser Lys Ile Ile Gln Asp Leu Glu Asn
465                 470                 475                 480 
Ser Ser Thr Tyr Ala Phe Arg Val Arg Ala Tyr Lys Gly Ser Ile Cys
                485                 490                 495     
Ser Pro Cys Ser Arg Glu Leu Ile Leu His Thr Pro Pro Ala Pro Val
            500                 505                 510         
Phe Ser Phe Leu Phe Asp Glu Lys Cys Gly Tyr Asn Asn Glu His Leu
        515                 520                 525             
Leu Leu Asn Leu Lys Arg Asp Arg Val Glu Ser Arg Ala Gly Phe Asn
    530                 535                 540                 
Leu Leu Leu Ala Ala Glu Arg Ile Gln Val Gly Tyr Tyr Thr Ser Leu
545                 550                 555                 560 
Asp Tyr Ile Ile Gly Asp Thr Gly Ile Thr Lys Gly Lys His Phe Trp
                565                 570                 575     
Ala Phe Arg Val Glu Pro Tyr Ser Tyr Leu Val Lys Val Gly Val Ala
            580                 585                 590         
Ser Ser Asp Lys Leu Gln Glu Trp Leu Arg Ser Pro Arg Asp Ala Val
        595                 600                 605             
Ser Pro Arg Tyr Glu Gln Asp Ser Gly His Asp Ser Gly Ser Glu Asp
    610                 615                 620                 
Ala Cys Phe Asp Ser Ser Gln Pro Phe Thr Leu Val Thr Ile Gly Met
625                 630                 635                 640 
Gln Lys Phe Phe Ile Pro Lys Ser Pro Thr Ser Ser Asn Glu Pro Glu
                645                 650                 655     
Asn Arg Val Leu Pro Met Pro Thr Ser Ile Gly Ile Phe Leu Asp Cys
            660                 665                 670         
Asp Lys Gly Lys Val Asn Phe Tyr Asp Met Asp Gln Met Lys Cys Leu
        675                 680                 685             
Tyr Glu Arg Gln Val Asp Cys Ser His Thr Leu Tyr Pro Ala Phe Ala
    690                 695                 700                 
Leu Met Gly Ser Gly Gly Ile Gln Leu Glu Glu Pro Ile Thr Ala Lys
705                 710                 715                 720 
Tyr Leu Glu Tyr Gln Glu Asp Met
                725             


<210> 8364
<211> 425
<212> PRT
<213> Homo sapiens

<400> 8364
Met Ala Asp Met Glu Asp Leu Phe Gly Ser Asp Ala Asp Ser Glu Ala
 1               5                  10                  15      
Glu Arg Lys Asp Ser Asp Ser Gly Ser Asp Ser Asp Ser Asp Gln Glu
            20                  25                  30          
Asn Ala Ala Ser Gly Ser Asn Ala Ser Gly Ser Glu Ser Asp Gln Asp
        35                  40                  45              
Glu Arg Gly Asp Ser Gly Gln Pro Ser Asn Lys Glu Leu Phe Gly Asp
    50                  55                  60                  
Asp Ser Glu Asp Glu Gly Ala Ser His His Ser Gly Ser Asp Asn His
65                  70                  75                  80  
Ser Glu Arg Ser Asp Asn Arg Ser Glu Ala Ser Glu Arg Ser Asp His
                85                  90                  95      
Glu Asp Asn Asp Pro Ser Asp Val Asp Gln His Ser Gly Ser Glu Ala
            100                 105                 110         
Pro Asn Asp Asp Glu Asp Glu Gly His Arg Ser Asp Gly Gly Ser His
        115                 120                 125             
His Ser Glu Ala Glu Gly Ser Glu Lys Ala His Ser Asp Asp Glu Lys
    130                 135                 140                 
Trp Gly Arg Glu Asp Lys Ser Asp Gln Ser Asp Asp Glu Lys Ile Gln
145                 150                 155                 160 
Asn Ser Asp Asp Glu Glu Arg Ala Gln Gly Ser Asp Glu Asp Lys Leu
                165                 170                 175     
Gln Asn Ser Asp Asp Asp Glu Lys Met Gln Asn Thr Asp Asp Glu Glu
            180                 185                 190         
Arg Pro Gln Leu Ser Asp Asp Glu Arg Gln Gln Leu Ser Glu Glu Glu
        195                 200                 205             
Lys Ala Asn Ser Asp Asp Glu Arg Pro Val Ala Ser Asp Asn Asp Asp
    210                 215                 220                 
Glu Lys Gln Asn Ser Asp Asp Glu Glu Gln Pro Gln Leu Ser Asp Glu
225                 230                 235                 240 
Glu Lys Met Gln Asn Ser Asp Asp Glu Arg Pro Gln Ala Ser Asp Glu
                245                 250                 255     
Glu His Arg His Ser Asp Asp Glu Glu Glu Gln Asp His Lys Ser Glu
            260                 265                 270         
Ser Ala Arg Gly Ser Asp Ser Glu Asp Glu Val Leu Arg Met Lys Arg
        275                 280                 285             
Lys Asn Ala Ile Ala Ser Asp Ser Glu Ala Asp Ser Asp Thr Glu Val
    290                 295                 300                 
Pro Lys Asp Asn Ser Gly Thr Met Asp Leu Phe Gly Gly Ala Asp Asp
305                 310                 315                 320 
Ile Ser Ser Gly Ser Asp Gly Glu Asp Lys Pro Pro Thr Pro Gly Gln
                325                 330                 335     
Pro Val Asp Glu Asn Gly Leu Pro Gln Asp Gln Gln Glu Glu Glu Pro
            340                 345                 350         
Ile Pro Glu Thr Arg Ile Glu Val Glu Ile Pro Lys Val Asn Thr Asp
        355                 360                 365             
Leu Gly Asn Asp Leu Tyr Phe Val Lys Leu Pro Asn Phe Leu Ser Val
    370                 375                 380                 
Glu Pro Ser Met Ser Leu His Leu Gly Asn Glu Val Phe Asp Val Tyr
385                 390                 395                 400 
Lys Ala Pro Leu Gln Gly Asp His Asn His Leu Phe Tyr Lys Thr Arg
                405                 410                 415     
Tyr Trp Ser Thr Gly Thr Ser Ser Leu
            420                 425 


<210> 8365
<211> 666
<212> PRT
<213> Homo sapiens

<400> 8365
Met Ala Asp Met Glu Asp Leu Phe Gly Ser Asp Ala Asp Ser Glu Ala
 1               5                  10                  15      
Glu Arg Lys Asp Ser Asp Ser Gly Ser Asp Ser Asp Ser Asp Gln Glu
            20                  25                  30          
Asn Ala Ala Ser Gly Ser Asn Ala Ser Gly Ser Glu Ser Asp Gln Asp
        35                  40                  45              
Glu Arg Gly Asp Ser Gly Gln Pro Ser Asn Lys Glu Leu Phe Gly Asp
    50                  55                  60                  
Asp Ser Glu Asp Glu Gly Ala Ser His His Ser Gly Ser Asp Asn His
65                  70                  75                  80  
Ser Glu Arg Ser Asp Asn Arg Ser Glu Ala Ser Glu Arg Ser Asp His
                85                  90                  95      
Glu Asp Asn Asp Pro Ser Asp Val Asp Gln His Ser Gly Ser Glu Ala
            100                 105                 110         
Pro Asn Asp Asp Glu Asp Glu Gly His Arg Ser Asp Gly Gly Ser His
        115                 120                 125             
His Ser Glu Ala Glu Gly Ser Glu Lys Ala His Ser Asp Asp Glu Lys
    130                 135                 140                 
Trp Gly Arg Glu Asp Lys Ser Asp Gln Ser Asp Asp Glu Lys Ile Gln
145                 150                 155                 160 
Asn Ser Asp Asp Glu Glu Arg Ala Gln Gly Ser Asp Glu Asp Lys Leu
                165                 170                 175     
Gln Asn Ser Asp Asp Asp Glu Lys Met Gln Asn Thr Asp Asp Glu Glu
            180                 185                 190         
Arg Pro Gln Leu Ser Asp Asp Glu Arg Gln Gln Leu Ser Glu Glu Glu
        195                 200                 205             
Lys Ala Asn Ser Asp Asp Glu Arg Pro Val Ala Ser Asp Asn Asp Asp
    210                 215                 220                 
Glu Lys Gln Asn Ser Asp Asp Glu Glu Gln Pro Gln Leu Ser Asp Glu
225                 230                 235                 240 
Glu Lys Met Gln Asn Ser Asp Asp Glu Arg Pro Gln Ala Ser Asp Glu
                245                 250                 255     
Glu His Arg His Ser Asp Asp Glu Glu Glu Gln Asp His Lys Ser Glu
            260                 265                 270         
Ser Ala Arg Gly Ser Asp Ser Glu Asp Glu Val Leu Arg Met Lys Arg
        275                 280                 285             
Lys Asn Ala Ile Ala Ser Asp Ser Glu Ala Asp Ser Asp Thr Glu Val
    290                 295                 300                 
Pro Lys Asp Asn Ser Gly Thr Met Asp Leu Phe Gly Gly Ala Asp Asp
305                 310                 315                 320 
Ile Ser Ser Gly Ser Asp Gly Glu Asp Lys Pro Pro Thr Pro Gly Gln
                325                 330                 335     
Pro Val Asp Glu Asn Gly Leu Pro Gln Asp Gln Gln Glu Glu Glu Pro
            340                 345                 350         
Ile Pro Glu Thr Arg Ile Glu Val Glu Ile Pro Lys Val Asn Thr Asp
        355                 360                 365             
Leu Gly Asn Asp Leu Tyr Phe Val Lys Leu Pro Asn Phe Leu Ser Val
    370                 375                 380                 
Glu Pro Arg Pro Phe Asp Pro Gln Tyr Tyr Glu Asp Glu Phe Glu Asp
385                 390                 395                 400 
Glu Glu Met Leu Asp Glu Glu Gly Arg Thr Arg Leu Lys Leu Lys Val
                405                 410                 415     
Glu Asn Thr Ile Arg Trp Arg Ile Arg Arg Asp Glu Glu Gly Asn Glu
            420                 425                 430         
Ile Lys Glu Ser Asn Ala Arg Ile Val Lys Trp Ser Asp Gly Ser Met
        435                 440                 445             
Ser Leu His Leu Gly Asn Glu Val Phe Asp Val Tyr Lys Ala Pro Leu
    450                 455                 460                 
Gln Gly Asp His Asn His Leu Phe Ile Arg Gln Gly Thr Gly Leu Gln
465                 470                 475                 480 
Gly Gln Ala Val Phe Lys Thr Lys Leu Thr Phe Arg Pro His Ser Thr
                485                 490                 495     
Asp Ser Ala Thr His Arg Lys Met Thr Leu Ser Leu Ala Asp Arg Cys
            500                 505                 510         
Ser Lys Thr Gln Lys Ile Arg Ile Leu Pro Met Ala Gly Arg Asp Pro
        515                 520                 525             
Glu Cys Gln Arg Thr Glu Met Ile Lys Lys Glu Glu Glu Arg Leu Arg
    530                 535                 540                 
Ala Ser Ile Arg Arg Glu Ser Gln Gln Arg Arg Met Arg Glu Lys Gln
545                 550                 555                 560 
His Gln Arg Gly Leu Ser Ala Ser Tyr Leu Glu Pro Asp Arg Tyr Asp
                565                 570                 575     
Glu Glu Glu Glu Gly Glu Glu Ser Ile Ser Leu Ala Ala Ile Lys Asn
            580                 585                 590         
Arg Tyr Lys Gly Gly Ile Arg Glu Glu Arg Ala Arg Ile Tyr Ser Ser
        595                 600                 605             
Asp Ser Asp Glu Gly Ser Glu Glu Asp Lys Ala Gln Arg Leu Leu Lys
    610                 615                 620                 
Ala Lys Lys Leu Thr Ser Asp Glu Glu Gly Glu Pro Ser Gly Lys Arg
625                 630                 635                 640 
Lys Ala Glu Asp Asp Asp Lys Ala Asn Lys Lys His Lys Lys Tyr Val
                645                 650                 655     
Ile Ser Asp Glu Glu Glu Glu Asp Asp Asp
            660                 665     


<210> 8366
<211> 1150
<212> PRT
<213> Homo sapiens

<400> 8366
Met Ser Lys Thr Leu Lys Lys Lys Lys His Trp Leu Ser Lys Val Gln
 1               5                  10                  15      
Glu Cys Ala Val Ser Trp Ala Gly Pro Pro Gly Asp Phe Gly Ala Glu
            20                  25                  30          
Ile Arg Gly Gly Ala Glu Arg Gly Glu Phe Pro Tyr Leu Gly Arg Leu
        35                  40                  45              
Arg Glu Glu Pro Gly Gly Gly Thr Cys Cys Ile Val Ser Gly Lys Ala
    50                  55                  60                  
Pro Asn Pro Ser Asp Val Leu Leu Glu Val Asn Gly Thr Pro Val Ser
65                  70                  75                  80  
Gly Leu Thr Asn Arg Asp Thr Leu Ala Val Ile Arg His Phe Arg Glu
                85                  90                  95      
Pro Ile Arg Leu Lys Thr Val Lys Pro Gly Lys Val Ile Asn Lys Asp
            100                 105                 110         
Leu Arg His Tyr Leu Ser Leu Gln Phe Gln Lys Gly Ser Ile Asp His
        115                 120                 125             
Lys Leu Gln Gln Val Ile Arg Asp Asn Leu Tyr Leu Arg Thr Ile Pro
    130                 135                 140                 
Cys Thr Thr Arg Ala Pro Arg Asp Gly Glu Val Pro Gly Val Asp Tyr
145                 150                 155                 160 
Asn Phe Ile Ser Val Glu Gln Phe Lys Ala Leu Glu Glu Ser Gly Ala
                165                 170                 175     
Leu Leu Glu Ser Gly Thr Tyr Asp Gly Asn Phe Tyr Gly Thr Pro Lys
            180                 185                 190         
Pro Pro Ala Glu Pro Ser Pro Phe Gln Pro Asp Pro Val Asp Gln Val
        195                 200                 205             
Leu Phe Asp Asn Glu Phe Asp Ala Glu Ser Gln Arg Lys Arg Thr Thr
    210                 215                 220                 
Ser Val Ser Lys Met Glu Arg Met Asp Ser Ser Leu Pro Glu Glu Glu
225                 230                 235                 240 
Glu Asp Glu Asp Lys Gly Ala Ile Asn Gly Ser Gly Asn Ala Glu Asn
                245                 250                 255     
Arg Glu Arg His Ser Glu Ser Ser Asp Trp Met Lys Thr Val Pro Ser
            260                 265                 270         
Tyr Asn Gln Thr Asn Ser Ser Met Asp Phe Arg Asn Tyr Met Met Arg
        275                 280                 285             
Asp Glu Thr Leu Glu Pro Leu Pro Lys Asn Trp Glu Met Ala Tyr Thr
    290                 295                 300                 
Asp Thr Gly Met Ile Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Thr
305                 310                 315                 320 
Trp Leu Asp Pro Arg Leu Cys Lys Lys Ala Lys Ala Pro Glu Asp Cys
                325                 330                 335     
Glu Asp Gly Glu Leu Pro Tyr Gly Trp Glu Lys Ile Glu Asp Pro Gln
            340                 345                 350         
Tyr Gly Thr Tyr Tyr Val Asp Phe Thr Leu Val Ala Gln Ala Gly Val
        355                 360                 365             
Gln Trp His Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Asn
    370                 375                 380                 
His Leu Asn Gln Lys Thr Gln Phe Glu Asn Pro Val Glu Glu Ala Lys
385                 390                 395                 400 
Arg Lys Lys Gln Leu Gly Gln Val Glu Ile Gly Ser Ser Lys Pro Asp
                405                 410                 415     
Met Glu Lys Ser His Phe Thr Arg Asp Pro Ser Gln Leu Lys Gly Val
            420                 425                 430         
Leu Val Arg Ala Ser Leu Lys Lys Ser Thr Met Gly Phe Gly Phe Thr
        435                 440                 445             
Ile Ile Gly Gly Asp Arg Pro Asp Glu Phe Leu Gln Val Lys Asn Val
    450                 455                 460                 
Leu Lys Asp Gly Pro Ala Ala Gln Asp Gly Lys Ile Ala Pro Gly Asp
465                 470                 475                 480 
Val Ile Val Asp Ile Asn Gly Asn Cys Val Phe Gly His Thr His Ala
                485                 490                 495     
Asp Val Val Gln Met Phe Gln Leu Val Pro Val Asn Gln Tyr Val Asn
            500                 505                 510         
Leu Thr Leu Cys Arg Gly Tyr Pro Leu Pro Asp Asp Ser Glu Asp Pro
        515                 520                 525             
Val Val Asp Ile Val Ala Ala Thr Pro Val Ile Asn Gly Gln Ser Leu
    530                 535                 540                 
Thr Lys Gly Glu Thr Cys Met Asn Pro Gln Asp Phe Lys Pro Gly Ala
545                 550                 555                 560 
Met Val Leu Glu Gln Asn Gly Lys Ser Gly His Thr Ser Thr Gly Asp
                565                 570                 575     
Gly Leu Asn Gly Pro Ser Asp Ala Ser Glu Gln Arg Val Ser Met Ala
            580                 585                 590         
Ser Ser Gly Ser Ser Gln Pro Glu Leu Val Thr Ile Pro Leu Ile Lys
        595                 600                 605             
Gly Pro Lys Gly Phe Gly Phe Ala Ile Ala Asp Ser Pro Thr Gly Gln
    610                 615                 620                 
Lys Val Lys Met Ile Leu Asp Ser Gln Trp Cys Gln Gly Leu Gln Lys
625                 630                 635                 640 
Glu Asp Ile Ile Lys Glu Ile Tyr His Gln Asn Val Gln Asn Leu Thr
                645                 650                 655     
His Leu Gln Val Val Glu Val Leu Lys Gln Phe Pro Val Gly Ala Asp
            660                 665                 670         
Val Pro Leu Leu Ile Leu Arg Gly Gly Pro Pro Ser Thr Thr Lys Thr
        675                 680                 685             
Ala Lys Met Lys Thr Asp Lys Lys Glu Asn Ala Gly Ser Leu Glu Ala
    690                 695                 700                 
Ile Asn Glu Pro Ile Pro Gln Pro Met Pro Phe Pro Pro Ser Ile Ile
705                 710                 715                 720 
Arg Ser Gly Ser Pro Lys Leu Asp Pro Ser Glu Val Tyr Leu Lys Ser
                725                 730                 735     
Lys Thr Leu Tyr Glu Asp Lys Pro Pro Asn Thr Lys Asp Leu Asp Val
            740                 745                 750         
Phe Leu Arg Lys Gln Glu Ser Gly Phe Gly Phe Arg Val Leu Gly Gly
        755                 760                 765             
Asp Gly Pro Asp Gln Ser Ile Tyr Ile Gly Ala Ile Ile Pro Leu Gly
    770                 775                 780                 
Ala Ala Glu Lys Asp Gly Arg Leu Arg Ala Ala Asp Glu Leu Met Cys
785                 790                 795                 800 
Ile Asp Gly Ile Pro Val Lys Gly Lys Ser His Lys Gln Val Leu Asp
                805                 810                 815     
Leu Met Thr Thr Ala Ala Arg Asn Gly His Val Leu Leu Thr Val Arg
            820                 825                 830         
Arg Lys Ile Phe Tyr Gly Glu Lys Gln Pro Glu Asp Asp Ser Ser Gln
        835                 840                 845             
Ala Phe Ile Ser Thr Gln Asn Gly Ser Pro Arg Leu Asn Arg Ala Glu
    850                 855                 860                 
Val Pro Ala Arg Pro Ala Pro Gln Glu Pro Tyr Asp Val Val Leu Gln
865                 870                 875                 880 
Arg Lys Glu Asn Glu Gly Phe Gly Phe Val Ile Leu Thr Ser Lys Asn
                885                 890                 895     
Lys Pro Pro Pro Gly Val Ile Pro His Lys Ile Gly Arg Val Ile Glu
            900                 905                 910         
Gly Ser Pro Ala Asp Arg Cys Gly Lys Leu Lys Val Gly Asp His Ile
        915                 920                 925             
Ser Ala Val Asn Gly Gln Ser Ile Val Glu Leu Ser His Ala Asn Ile
    930                 935                 940                 
Val Gln Leu Ile Lys Asp Ala Gly Val Thr Val Thr Leu Thr Val Ile
945                 950                 955                 960 
Ala Glu Glu Glu His His Gly Pro Pro Ser Gly Thr Asn Ser Ala Arg
                965                 970                 975     
Gln Ser Pro Ala Leu Gln His Arg Pro Met Gly Gln Ser Gln Ala Asn
            980                 985                 990         
His Ile Pro Gly Asp Arg Ser Ala Leu Glu Gly Glu Ile Gly Lys Asp
        995                 1000                1005            
Val Ser Thr Ser Tyr Arg His Ser Trp Ser Asp His Lys His Leu Ala
    1010                1015                1020                
Gln Pro Asp Thr Ala Val Ile Ser Val Val Gly Ser Arg His Asn Gln
1025                1030                1035                1040
Asn Leu Gly Cys Tyr Pro Val Glu Leu Glu Arg Gly Pro Arg Gly Phe
                1045                1050                1055    
Gly Phe Ser Leu Arg Gly Gly Lys Glu Tyr Asn Met Gly Leu Phe Ile
            1060                1065                1070        
Leu Arg Leu Ala Glu Asp Gly Pro Ala Ile Lys Asp Gly Arg Ile His
        1075                1080                1085            
Val Gly Asp Gln Ile Val Glu Ile Asn Gly Glu Pro Thr Gln Gly Ile
    1090                1095                1100                
Thr His Thr Arg Ala Ile Glu Leu Ile Gln Ala Gly Gly Asn Lys Val
1105                1110                1115                1120
Leu Leu Leu Leu Arg Pro Gly Thr Gly Leu Ile Pro Asp His Gly Leu
                1125                1130                1135    
Ala Pro Ser Gly Leu Cys Ser Tyr Val Lys Pro Glu Gln His
            1140                1145                1150


<210> 8367
<211> 1027
<212> PRT
<213> Homo sapiens

<400> 8367
Asp Val Ile Val Asp Ile Asn Gly Asn Cys Val Leu Gly His Thr His
 1               5                  10                  15      
Ala Asp Val Val Gln Met Phe Gln Leu Val Pro Val Asn Gln Tyr Val
            20                  25                  30          
Asn Leu Thr Leu Cys Arg Gly Tyr Pro Leu Pro Asp Asp Ser Glu Asp
        35                  40                  45              
Pro Val Val Asp Ile Val Ala Ala Thr Pro Val Ile Asn Gly Gln Ser
    50                  55                  60                  
Leu Thr Lys Gly Glu Thr Cys Met Asn Pro Gln Asp Phe Lys Pro Gly
65                  70                  75                  80  
Ala Met Val Leu Glu Gln Asn Gly Lys Ser Gly His Thr Leu Thr Gly
                85                  90                  95      
Asp Gly Leu Asn Gly Pro Ser Asp Ala Ser Glu Gln Arg Val Ser Met
            100                 105                 110         
Ala Ser Ser Gly Ser Ser Gln Pro Glu Leu Val Thr Ile Pro Leu Ile
        115                 120                 125             
Lys Gly Pro Lys Gly Phe Gly Phe Ala Ile Ala Asp Ser Pro Thr Gly
    130                 135                 140                 
Gln Lys Val Lys Met Ile Leu Asp Ser Gln Trp Cys Gln Gly Leu Gln
145                 150                 155                 160 
Lys Gly Asp Ile Ile Lys Glu Ile Tyr His Gln Asn Val Gln Asn Leu
                165                 170                 175     
Thr His Leu Gln Val Val Glu Val Leu Lys Gln Phe Pro Val Gly Ala
            180                 185                 190         
Asp Val Pro Leu Leu Ile Leu Arg Gly Gly Pro Pro Ser Pro Thr Lys
        195                 200                 205             
Thr Ala Lys Met Lys Thr Asp Lys Lys Glu Asn Ala Gly Ser Leu Glu
    210                 215                 220                 
Ala Ile Asn Glu Pro Ile Pro Gln Pro Met Pro Phe Pro Pro Ser Ile
225                 230                 235                 240 
Ile Arg Ser Gly Ser Pro Lys Leu Asp Pro Ser Glu Val Tyr Leu Lys
                245                 250                 255     
Ser Lys Thr Leu Tyr Glu Asp Lys Pro Pro Asn Thr Lys Asp Leu Asp
            260                 265                 270         
Val Phe Leu Arg Lys Gln Glu Ser Gly Phe Gly Phe Arg Val Leu Gly
        275                 280                 285             
Gly Asp Gly Pro Asp Gln Ser Ile Tyr Ile Gly Ala Ile Ile Pro Leu
    290                 295                 300                 
Gly Ala Ala Glu Lys Asp Gly Arg Leu Arg Ala Ala Asp Glu Leu Met
305                 310                 315                 320 
Cys Ile Asp Gly Ile Pro Val Lys Gly Lys Ser His Lys Gln Val Leu
                325                 330                 335     
Asp Leu Met Thr Thr Ala Ala Arg Asn Gly His Val Leu Leu Thr Val
            340                 345                 350         
Arg Arg Lys Ile Phe Tyr Gly Glu Lys Gln Pro Glu Asp Asp Ser Ser
        355                 360                 365             
Gln Ala Phe Ile Ser Thr Gln Asn Gly Ser Pro Arg Leu Asn Arg Ala
    370                 375                 380                 
Glu Val Pro Ala Arg Pro Ala Pro Gln Glu Pro Tyr Asp Val Val Leu
385                 390                 395                 400 
Gln Arg Lys Glu Asn Glu Gly Phe Gly Phe Val Ile Leu Thr Ser Lys
                405                 410                 415     
Asn Lys Pro Pro Pro Gly Val Ile Pro His Lys Ile Gly Arg Val Ile
            420                 425                 430         
Glu Gly Ser Pro Ala Asp Arg Cys Gly Lys Leu Lys Val Gly Asp His
        435                 440                 445             
Ile Ser Ala Val Asn Gly Gln Ser Ile Val Glu Leu Ser His Asp Asn
    450                 455                 460                 
Ile Val Gln Leu Ile Lys Asp Ala Gly Val Thr Val Thr Leu Thr Val
465                 470                 475                 480 
Ile Ala Glu Glu Glu His His Gly Pro Pro Ser Gly Thr Asn Ser Ala
                485                 490                 495     
Arg Gln Ser Pro Ala Leu Gln His Arg Pro Met Gly Gln Ser Gln Ala
            500                 505                 510         
Asn His Ile Pro Gly Asp Arg Ser Ala Leu Glu Gly Glu Ile Gly Lys
        515                 520                 525             
Asp Val Ser Thr Ser Tyr Arg His Ser Trp Ser Asp His Lys His Leu
    530                 535                 540                 
Ala Gln Pro Asp Thr Ala Val Ile Ser Val Val Gly Ser Arg His Asn
545                 550                 555                 560 
Gln Asn Leu Gly Cys Tyr Pro Val Glu Leu Glu Arg Gly Pro Arg Gly
                565                 570                 575     
Phe Gly Phe Ser Leu Arg Gly Gly Lys Glu Tyr Asn Met Gly Leu Phe
            580                 585                 590         
Ile Leu Arg Leu Ala Glu Asp Gly Pro Ala Ile Lys Asp Gly Arg Ile
        595                 600                 605             
His Val Gly Asp Gln Ile Val Glu Ile Asn Gly Glu Pro Thr Gln Gly
    610                 615                 620                 
Ile Thr His Thr Arg Ala Ile Glu Leu Ile Gln Ala Gly Gly Asn Lys
625                 630                 635                 640 
Val Leu Leu Leu Leu Arg Pro Gly Thr Gly Leu Ile Pro Asp His Gly
                645                 650                 655     
Asp Trp Asp Ile Asn Asn Pro Ser Ser Ser Asn Val Ile Tyr Asp Glu
            660                 665                 670         
Gln Ser Pro Leu Pro Pro Ser Ser His Phe Ala Ser Ile Phe Glu Glu
        675                 680                 685             
Ser His Val Pro Val Ile Glu Glu Ser Leu Arg Val Gln Ile Cys Glu
    690                 695                 700                 
Lys Ala Glu Glu Leu Lys Asp Ile Val Pro Glu Lys Lys Ser Thr Leu
705                 710                 715                 720 
Asn Glu Asn Gln Pro Glu Ile Lys His Gln Ser Leu Leu Gln Lys Asn
                725                 730                 735     
Val Ser Lys Arg Asp Pro Pro Ser Ser His Gly His Ser Asn Lys Lys
            740                 745                 750         
Asn Leu Leu Lys Val Glu Asn Gly Val Thr Arg Arg Gly Arg Ser Val
        755                 760                 765             
Ser Pro Lys Lys Pro Ala Ser Gln His Ser Glu Glu His Leu Asp Lys
    770                 775                 780                 
Ile Pro Ser Pro Leu Lys Asn Asn Pro Lys Arg Arg Pro Arg Asp Gln
785                 790                 795                 800 
Ser Leu Ser Pro Ser Lys Gly Glu Asn Lys Ser Cys Gln Val Ser Thr
                805                 810                 815     
Arg Ala Gly Ser Gly Gln Asp Gln Cys Arg Lys Ser Arg Gly Arg Ser
            820                 825                 830         
Ala Ser Pro Lys Lys Gln Gln Lys Ile Glu Gly Ser Lys Ala Pro Ser
        835                 840                 845             
Asn Ala Glu Ala Lys Leu Leu Glu Gly Lys Ser Arg Arg Ile Ala Gly
    850                 855                 860                 
Tyr Thr Gly Ser Asn Ala Glu Gln Ile Pro Asp Gly Lys Glu Lys Ser
865                 870                 875                 880 
Asp Val Ile Arg Lys Asp Ala Lys Gln Asn Gln Leu Glu Lys Ser Arg
                885                 890                 895     
Thr Arg Ser Pro Glu Lys Lys Ile Lys Arg Met Val Glu Lys Ser Leu
            900                 905                 910         
Pro Ser Lys Met Thr Asn Lys Thr Thr Ser Lys Glu Val Ser Glu Asn
        915                 920                 925             
Glu Lys Gly Lys Lys Val Thr Thr Gly Glu Thr Ser Ser Ser Asn Asp
    930                 935                 940                 
Lys Ile Gly Glu Asn Val Gln Leu Ser Glu Lys Arg Leu Lys Gln Glu
945                 950                 955                 960 
Pro Glu Glu Lys Val Val Ser Asn Lys Thr Glu Asp His Lys Gly Lys
                965                 970                 975     
Glu Leu Glu Ala Ala Asp Lys Asn Lys Glu Thr Gly Arg Phe Lys Pro
            980                 985                 990         
Glu Ser Ser Ser Pro Val Lys Lys Thr Leu Ile Thr Pro Gly Pro Trp
        995                 1000                1005            
Lys Val Pro Ser Gly Asn Lys Val Thr Gly Thr Ile Gly Met Ala Glu
    1010                1015                1020                
Lys Arg Gln
1025        


<210> 8368
<211> 1125
<212> PRT
<213> Homo sapiens

<400> 8368
Met Ser Lys Thr Leu Lys Lys Lys Arg His Trp Leu Ser Lys Val Gln
 1               5                  10                  15      
Glu Cys Ala Val Ser Trp Ala Gly Pro Pro Gly Asp Phe Gly Ala Glu
            20                  25                  30          
Ile Arg Gly Gly Ala Glu Arg Gly Glu Phe Pro Tyr Leu Gly Arg Leu
        35                  40                  45              
Arg Glu Glu Pro Gly Gly Gly Thr Cys Cys Val Val Ser Gly Lys Ala
    50                  55                  60                  
Pro Ser Pro Gly Asp Val Leu Leu Glu Val Asn Gly Thr Pro Val Ser
65                  70                  75                  80  
Gly Leu Thr Asn Arg Asp Thr Leu Ala Val Ile Arg His Phe Arg Glu
                85                  90                  95      
Pro Ile Arg Leu Lys Thr Val Lys Pro Gly Lys Val Ile Asn Lys Asp
            100                 105                 110         
Leu Arg His Tyr Leu Ser Leu Gln Phe Gln Lys Gly Ser Ile Asp His
        115                 120                 125             
Lys Leu Gln Gln Val Ile Arg Asp Asn Leu Tyr Leu Arg Thr Ile Pro
    130                 135                 140                 
Cys Thr Thr Arg Ala Pro Arg Asp Gly Glu Val Pro Gly Val Asp Tyr
145                 150                 155                 160 
Asn Phe Ile Ser Val Glu Gln Phe Lys Ala Leu Glu Glu Ser Gly Ala
                165                 170                 175     
Leu Leu Glu Ser Gly Thr Tyr Asp Gly Asn Phe Tyr Gly Thr Pro Lys
            180                 185                 190         
Pro Pro Ala Glu Pro Ser Pro Phe Gln Pro Asp Pro Val Asp Gln Val
        195                 200                 205             
Leu Phe Asp Asn Glu Phe Asp Ala Glu Ser Gln Arg Lys Arg Thr Thr
    210                 215                 220                 
Ser Val Ser Lys Met Glu Arg Met Asp Ser Ser Leu Pro Glu Glu Glu
225                 230                 235                 240 
Glu Asp Glu Asp Lys Glu Ala Ile Asn Gly Ser Gly Asn Ala Glu Asn
                245                 250                 255     
Gly Glu Arg His Ser Glu Ser Ser Asp Trp Met Lys Thr Val Pro Ser
            260                 265                 270         
Tyr Asn Gln Thr Asn Ser Ser Met Asp Phe Arg Asn Tyr Met Met Arg
        275                 280                 285             
Asp Glu Thr Leu Glu Pro Leu Pro Lys Asn Trp Glu Met Ala Tyr Thr
    290                 295                 300                 
Asp Thr Gly Met Ile Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Thr
305                 310                 315                 320 
Trp Leu Asp Pro Arg Leu Cys Lys Lys Ala Lys Ala Pro Glu Asp Cys
                325                 330                 335     
Glu Asp Gly Glu Leu Pro Tyr Gly Trp Glu Lys Ile Glu Asp Pro Gln
            340                 345                 350         
Tyr Gly Thr Tyr Tyr Val Asp His Leu Asn Gln Lys Thr Gln Phe Glu
        355                 360                 365             
Asn Pro Val Glu Glu Ala Lys Arg Lys Lys Gln Leu Gly Gln Val Glu
    370                 375                 380                 
Ile Gly Ser Ser Lys Pro Asp Met Glu Lys Ser His Phe Thr Arg Asp
385                 390                 395                 400 
Pro Ser Gln Leu Lys Gly Val Leu Val Arg Ala Ser Leu Lys Lys Ser
                405                 410                 415     
Thr Met Gly Phe Gly Phe Thr Ile Ile Gly Gly Asp Arg Pro Asp Glu
            420                 425                 430         
Phe Leu Gln Val Lys Asn Val Leu Lys Asp Gly Pro Ala Ala Gln Asp
        435                 440                 445             
Gly Lys Ile Ala Pro Gly Asp Val Ile Val Asp Ile Asn Gly Asn Cys
    450                 455                 460                 
Val Leu Gly His Thr His Ala Asp Val Val Gln Met Phe Gln Leu Val
465                 470                 475                 480 
Pro Val Asn Gln Tyr Val Asn Leu Thr Leu Cys Arg Gly Tyr Pro Leu
                485                 490                 495     
Pro Asp Asp Ser Glu Asp Pro Val Val Asp Ile Val Ala Ala Thr Pro
            500                 505                 510         
Val Ile Asn Gly Gln Ser Leu Thr Lys Gly Glu Thr Cys Met Asn Pro
        515                 520                 525             
Gln Asp Phe Lys Pro Gly Ala Met Val Leu Glu Gln Asn Gly Lys Ser
    530                 535                 540                 
Gly His Thr Leu Thr Gly Asp Gly Leu Asn Gly Pro Ser Asp Ala Ser
545                 550                 555                 560 
Glu Gln Arg Val Ser Met Ala Ser Ser Gly Ser Ser Gln Pro Glu Leu
                565                 570                 575     
Val Thr Ile Pro Leu Ile Lys Gly Pro Lys Gly Phe Gly Phe Ala Ile
            580                 585                 590         
Ala Asp Ser Pro Thr Gly Gln Lys Val Lys Met Ile Leu Asp Ser Gln
        595                 600                 605             
Trp Cys Gln Gly Leu Gln Lys Gly Asp Ile Ile Lys Glu Ile Tyr His
    610                 615                 620                 
Gln Asn Val Gln Asn Leu Thr His Leu Gln Val Val Glu Val Leu Lys
625                 630                 635                 640 
Gln Phe Pro Val Gly Ala Asp Val Pro Leu Leu Ile Leu Arg Gly Gly
                645                 650                 655     
Pro Pro Ser Pro Thr Lys Thr Ala Lys Met Lys Thr Asp Lys Lys Glu
            660                 665                 670         
Asn Ala Gly Ser Leu Glu Ala Ile Asn Glu Pro Ile Pro Gln Pro Met
        675                 680                 685             
Pro Phe Pro Pro Ser Ile Ile Arg Ser Gly Ser Pro Lys Leu Asp Pro
    690                 695                 700                 
Ser Glu Val Tyr Leu Lys Ser Lys Thr Leu Tyr Glu Asp Lys Pro Pro
705                 710                 715                 720 
Asn Thr Lys Asp Leu Asp Val Phe Leu Arg Lys Gln Glu Ser Gly Phe
                725                 730                 735     
Gly Phe Arg Val Leu Gly Gly Asp Gly Pro Asp Gln Ser Ile Tyr Ile
            740                 745                 750         
Gly Ala Ile Ile Pro Leu Gly Ala Ala Glu Lys Asp Gly Arg Leu Arg
        755                 760                 765             
Ala Ala Asp Glu Leu Met Cys Val Asp Gly Ile Pro Val Lys Gly Lys
    770                 775                 780                 
Ser His Lys Gln Val Leu Asp Leu Met Thr Thr Ala Ala Pro Asn Gly
785                 790                 795                 800 
His Val Leu Leu Thr Val Arg Arg Lys Ile Phe Tyr Gly Glu Lys Gln
                805                 810                 815     
Pro Glu Asp Asp Ser Ser Gln Ala Phe Ile Ser Thr Gln Asn Gly Ser
            820                 825                 830         
Pro Arg Leu Asn Arg Ala Glu Val Pro Ala Arg Pro Ala Pro Gln Glu
        835                 840                 845             
Pro Tyr Asp Val Val Leu Gln Arg Lys Glu Asn Glu Gly Phe Gly Phe
    850                 855                 860                 
Val Ile Leu Thr Ser Lys Asn Lys Pro Pro Pro Gly Val Ile Pro His
865                 870                 875                 880 
Lys Ile Gly Arg Val Ile Glu Gly Ser Pro Ala Asp Arg Cys Gly Lys
                885                 890                 895     
Leu Lys Val Gly Asp His Ile Ser Ala Val Asn Gly Gln Ser Ile Val
            900                 905                 910         
Glu Leu Ser His Asp Asn Ile Val Gln Leu Ile Lys Asp Ala Gly Val
        915                 920                 925             
Thr Val Thr Leu Thr Val Ile Ala Glu Glu Glu His His Gly Pro Pro
    930                 935                 940                 
Ser Gly Thr Asn Ser Ala Arg Gln Ser Pro Ala Leu Gln His Arg Pro
945                 950                 955                 960 
Met Gly Gln Ser Gln Ala Asn His Ile Pro Gly Asp Arg Ser Ala Leu
                965                 970                 975     
Glu Gly Glu Ile Gly Lys Asp Val Ser Thr Ser Tyr Arg His Ser Trp
            980                 985                 990         
Pro Asp His Lys His Leu Ala Gln Pro Asp Thr Ala Val Ile Ser Val
        995                 1000                1005            
Val Gly Ser Arg His Asn Gln Asn Leu Gly Cys Tyr Pro Val Glu Leu
    1010                1015                1020                
Glu Arg Gly Pro Arg Gly Phe Gly Phe Ser Leu Arg Gly Gly Lys Glu
1025                1030                1035                1040
Tyr Asn Met Gly Leu Phe Ile Leu Arg Leu Ala Glu Asp Gly Pro Ala
                1045                1050                1055    
Ile Lys Asp Gly Arg Ile His Val Gly Asp Gln Ile Val Glu Ile Asn
            1060                1065                1070        
Gly Glu Pro Thr Gln Gly Ile Thr His Thr Arg Ala Ile Glu Leu Ile
        1075                1080                1085            
Gln Ala Gly Gly Asn Lys Val Leu Leu Leu Leu Arg Pro Gly Thr Gly
    1090                1095                1100                
Leu Ile Pro Asp His Gly Leu Ala Pro Ser Gly Leu Cys Ser Tyr Val
1105                1110                1115                1120
Lys Pro Glu Gln His
                1125


<210> 8369
<211> 1432
<212> PRT
<213> Homo sapiens

<400> 8369
Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly
 1               5                  10                  15      
Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu
            20                  25                  30          
Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg
        35                  40                  45              
Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu
    50                  55                  60                  
Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His
65                  70                  75                  80  
Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val
                85                  90                  95      
Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr
            100                 105                 110         
Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr
        115                 120                 125             
Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn
    130                 135                 140                 
Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile
145                 150                 155                 160 
Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn
                165                 170                 175     
Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu
            180                 185                 190         
Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr
        195                 200                 205             
Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu
    210                 215                 220                 
Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr
225                 230                 235                 240 
Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu
                245                 250                 255     
Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His
            260                 265                 270         
Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala
        275                 280                 285             
Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys
    290                 295                 300                 
Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg
305                 310                 315                 320 
Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr
                325                 330                 335     
Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile
            340                 345                 350         
Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser
        355                 360                 365             
Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu
    370                 375                 380                 
Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys
385                 390                 395                 400 
Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val
                405                 410                 415     
Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser
            420                 425                 430         
Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala
        435                 440                 445             
Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Val Gln
    450                 455                 460                 
Val Leu Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu
465                 470                 475                 480 
Glu Thr Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala
                485                 490                 495     
Lys Ala Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu
            500                 505                 510         
Gly Glu Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile
        515                 520                 525             
Val Glu Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys
    530                 535                 540                 
Asp Gly His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu
545                 550                 555                 560 
Val Ile Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp
                565                 570                 575     
Arg His Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met
            580                 585                 590         
Pro Ile Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser
        595                 600                 605             
Asn Lys Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile
    610                 615                 620                 
Leu Asp Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala
625                 630                 635                 640 
Leu Thr Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln
                645                 650                 655     
His Glu His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His
            660                 665                 670         
Arg Gly Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro
        675                 680                 685             
Arg Ile Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr
    690                 695                 700                 
Leu Val Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg
705                 710                 715                 720 
Arg Arg Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser
                725                 730                 735     
Pro Leu Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr
            740                 745                 750         
Pro Gly Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu
        755                 760                 765             
Pro Gly Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His
    770                 775                 780                 
His Pro His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile
785                 790                 795                 800 
Gln Asn Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe
                805                 810                 815     
Ser Gly Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn
            820                 825                 830         
Asp Pro Thr Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr
        835                 840                 845             
Glu Ile Gln Leu Asn Pro Val Ile Phe Trp Leu Ser Phe Leu Lys Ser
    850                 855                 860                 
Leu Val Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn
865                 870                 875                 880 
Pro Leu Gln Val Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val
                885                 890                 895     
Pro Arg Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu
            900                 905                 910         
Leu Lys Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn
        915                 920                 925             
Lys Leu Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys
    930                 935                 940                 
Val Leu Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val
945                 950                 955                 960 
Cys Pro Pro Met Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro
                965                 970                 975     
Ser Trp Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln
            980                 985                 990         
Phe Val Tyr Asp Val Gln Asp Gln Leu Asn Pro Leu Ala Ser Glu Glu
        995                 1000                1005            
Asp Leu Arg Arg Ile Ala Gln Gln Leu His Ser Thr Gly Glu Ile Asn
    1010                1015                1020                
Ile Met Gln Ser Glu Thr Val Gln Asp Val Leu Leu Leu Asp Pro Arg
1025                1030                1035                1040
Trp Leu Cys Thr Asn Val Leu Gly Lys Leu Leu Ser Val Glu Thr Pro
                1045                1050                1055    
Arg Ala Leu His His Tyr Arg Gly Arg Tyr Thr Val Glu Asp Ile Gln
            1060                1065                1070        
Arg Leu Val Pro Asp Ser Asp Val Glu Glu Leu Leu Gln Ile Leu Asp
        1075                1080                1085            
Ala Met Asp Ile Cys Ala Arg Asp Leu Ser Ser Gly Thr Met Val Asp
    1090                1095                1100                
Val Pro Ala Leu Ile Lys Thr Asp Asn Leu His Arg Ser Trp Ala Asp
1105                1110                1115                1120
Glu Glu Asp Glu Val Met Val Tyr Gly Gly Val Arg Ile Val Pro Val
                1125                1130                1135    
Glu His Leu Thr Pro Phe Pro Cys Gly Ile Phe His Lys Val Gln Val
            1140                1145                1150        
Asn Leu Cys Arg Trp Ile His Gln Gln Ser Thr Glu Gly Asp Ala Asp
        1155                1160                1165            
Ile Arg Leu Trp Val Asn Gly Cys Lys Leu Ala Asn Arg Gly Ala Glu
    1170                1175                1180                
Leu Leu Val Leu Leu Val Asn His Gly Gln Gly Ile Glu Val Gln Val
1185                1190                1195                1200
Arg Gly Leu Glu Thr Glu Lys Ile Lys Cys Cys Leu Leu Leu Asp Ser
                1205                1210                1215    
Val Cys Ser Thr Ile Glu Asn Val Met Ala Thr Thr Leu Pro Gly Leu
            1220                1225                1230        
Leu Thr Val Lys His Tyr Leu Ser Pro Gln Gln Leu Arg Glu His His
        1235                1240                1245            
Glu Pro Val Met Ile Tyr Gln Pro Arg Asp Phe Phe Arg Ala Gln Thr
    1250                1255                1260                
Leu Lys Glu Thr Ser Leu Thr Asn Thr Met Gly Gly Tyr Lys Glu Ser
1265                1270                1275                1280
Phe Ser Ser Ile Met Cys Phe Gly Cys His Asp Val Tyr Ser Gln Ala
                1285                1290                1295    
Ser Leu Gly Met Asp Ile His Ala Ser Asp Leu Asn Leu Leu Thr Arg
            1300                1305                1310        
Arg Lys Leu Ser Arg Leu Leu Asp Pro Pro Asp Pro Leu Gly Lys Asp
        1315                1320                1325            
Trp Cys Leu Leu Ala Met Asn Leu Gly Leu Pro Asp Leu Val Ala Lys
    1330                1335                1340                
Tyr Asn Thr Asn Asn Gly Ala Pro Lys Asp Phe Leu Pro Ser Pro Leu
1345                1350                1355                1360
His Ala Leu Leu Arg Glu Trp Thr Thr Tyr Pro Glu Ser Thr Val Gly
                1365                1370                1375    
Thr Leu Met Ser Lys Leu Arg Glu Leu Gly Arg Arg Asp Ala Ala Asp
            1380                1385                1390        
Leu Leu Leu Lys Ala Ser Ser Val Phe Lys Ile Asn Leu Asp Gly Asn
        1395                1400                1405            
Gly Gln Glu Ala Tyr Ala Ser Ser Cys Asn Ser Gly Thr Ser Tyr Asn
    1410                1415                1420                
Ser Ile Ser Ser Val Val Ser Arg
1425                1430        


<210> 8370
<211> 539
<212> PRT
<213> Homo sapiens

<400> 8370
Gln Ile Pro Val Ser Phe Gln Asp Leu Thr Val Asn Phe Thr Gln Glu
 1               5                  10                  15      
Glu Trp Gln Gln Leu Asp Pro Ala Gln Arg Leu Leu Tyr Arg Asp Val
            20                  25                  30          
Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr His Val Ser
        35                  40                  45              
Lys Pro Asp Val Ile Phe Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile
    50                  55                  60                  
Val Glu Glu Phe Ser Asn Gln Asn Tyr Pro Asp Ile Asp Asp Ala Leu
65                  70                  75                  80  
Glu Lys Asn Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr Val Phe
                85                  90                  95      
Phe Ser Asn Lys Thr Leu Ile Thr Glu Arg Glu Asn Val Phe Gly Lys
            100                 105                 110         
Thr Leu Asn Leu Gly Met Asn Ser Val Pro Ser Arg Lys Met Pro Tyr
        115                 120                 125             
Lys Cys Asn Pro Gly Gly Asn Ser Leu Lys Thr Asn Ser Glu Ile Leu
    130                 135                 140                 
Lys Gln Pro Phe Asp Tyr Asn Lys Cys Gly Lys Thr Phe Phe Lys Arg
145                 150                 155                 160 
Ala Ile Leu Ile Thr Gln Lys Gly Arg Gln Thr Glu Arg Lys Pro Asn
                165                 170                 175     
Glu Cys Asn Glu Cys Arg Lys Thr Phe Ser Lys Arg Ser Thr Leu Ile
            180                 185                 190         
Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Ser Asp
        195                 200                 205             
Cys Arg Lys Thr Phe Arg Val Lys Thr Ser Leu Thr Arg His Arg Arg
    210                 215                 220                 
Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Arg Lys Thr
225                 230                 235                 240 
Phe Ile Asp Lys Ser Ala Leu Ile Val His Gln Lys Ile His Gly Gly
                245                 250                 255     
Glu Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Phe Arg Lys
            260                 265                 270         
Ser Ala Leu Ala Glu His Phe Arg Ser His Thr Gly Glu Lys Pro Tyr
        275                 280                 285             
Glu Cys Lys Glu Cys Gly Asn Ala Phe Ser Lys Lys Ser Tyr Leu Val
    290                 295                 300                 
Val His Gln Arg Thr His Arg Gly Glu Lys Pro Asn Glu Cys Lys Glu
305                 310                 315                 320 
Cys Gly Lys Thr Phe Phe Cys Gln Ser Ala Leu Thr Ala His Gln Arg
                325                 330                 335     
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Glu Lys Thr
            340                 345                 350         
Phe Phe Cys Gln Ser Ala Leu Asn Val His Arg Arg Ser His Thr Gly
        355                 360                 365             
Glu Lys Pro Tyr Glu Cys Ser Gln Cys Gly Lys Phe Leu Cys Thr Lys
    370                 375                 380                 
Ser Ala Leu Ile Ala His Gln Ile Thr His Arg Gly Lys Lys Ser Tyr
385                 390                 395                 400 
Glu Cys Asn Glu Cys Gly Lys Phe Phe Cys His Lys Ser Thr Leu Thr
                405                 410                 415     
Ile His Gln Arg Thr His Thr Gly Glu Lys His Gly Gln Arg Pro Tyr
            420                 425                 430         
Glu Cys Asn Glu Cys Gly Lys Thr Phe Cys Gln Lys Phe Ser Phe Val
        435                 440                 445             
Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu
    450                 455                 460                 
Cys Gly Lys Ser Phe Cys His Lys Ser Ala Phe Arg Val His Arg Arg
465                 470                 475                 480 
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Thr
                485                 490                 495     
Tyr Arg Arg Leu Trp Thr Leu Thr Glu His Gln Lys Ile His Thr Gly
            500                 505                 510         
Glu Lys Pro Tyr Glu Cys Asn Lys Cys Glu Lys Thr Phe Arg His Lys
        515                 520                 525             
Ser Asn Phe Leu Leu His Gln Lys Ser His Lys
    530                 535                 


<210> 8371
<211> 708
<212> PRT
<213> Homo sapiens

<400> 8371
Glu Gly Leu Ala Ala Ser Ser Glu His Ser Gly Val Gly Gly Asn Ala
 1               5                  10                  15      
Leu Leu Ser Thr Leu Leu Ala Leu Ser Gln Glu Asn Met Lys Met Lys
            20                  25                  30          
Lys Phe Gln Ile Pro Val Ser Phe Gln Asp Leu Thr Val Asn Phe Thr
        35                  40                  45              
Gln Glu Glu Trp Gln Gln Leu Asp Pro Ala Gln Arg Leu Leu Tyr Arg
    50                  55                  60                  
Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr His
65                  70                  75                  80  
Val Ser Lys Pro Asp Val Ile Phe Lys Leu Glu Gln Gly Glu Glu Pro
                85                  90                  95      
Trp Ile Val Glu Glu Phe Ser Asn Gln Asn Tyr Pro Asp Ile Asp Asp
            100                 105                 110         
Ala Leu Glu Lys Asn Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr
        115                 120                 125             
Val Phe Phe Ser Asn Lys Thr Leu Ile Thr Glu Arg Glu Asn Val Phe
    130                 135                 140                 
Gly Lys Thr Leu Asn Leu Gly Met Asn Ser Val Pro Ser Arg Lys Met
145                 150                 155                 160 
Pro Tyr Lys Cys Asn Pro Gly Gly Asn Ser Leu Lys Thr Asn Ser Glu
                165                 170                 175     
Val Ile Val Ala Lys Lys Ser Lys Glu Asn Arg Lys Ile Pro Asp Gly
            180                 185                 190         
Tyr Ser Gly Phe Gly Lys His Glu Lys Ser His Leu Gly Met Lys Lys
        195                 200                 205             
Tyr Arg Tyr Asn Pro Met Arg Lys Ala Ser Asn Gln Asn Glu Asn Leu
    210                 215                 220                 
Ile Leu His Gln Asn Ile Gln Ile Leu Lys Gln Pro Phe Asp Tyr Asn
225                 230                 235                 240 
Lys Cys Gly Lys Thr Phe Phe Lys Arg Ala Ile Leu Ile Thr Gln Lys
                245                 250                 255     
Gly Arg Gln Thr Glu Arg Lys Pro Asn Glu Cys Asn Glu Cys Arg Lys
            260                 265                 270         
Thr Phe Ser Lys Arg Ser Thr Leu Ile Val His Gln Arg Ile His Thr
        275                 280                 285             
Gly Glu Lys Pro Tyr Val Cys Ser Asp Cys Arg Lys Thr Phe Arg Val
    290                 295                 300                 
Lys Thr Ser Leu Thr Arg His Arg Arg Ile His Thr Gly Glu Arg Pro
305                 310                 315                 320 
Tyr Glu Cys Ser Glu Cys Arg Lys Thr Phe Ile Asp Lys Ser Ala Leu
                325                 330                 335     
Ile Val His Gln Lys Ile His Gly Gly Glu Lys Ser Tyr Glu Cys Asn
            340                 345                 350         
Glu Cys Gly Lys Thr Phe Phe Arg Lys Ser Ala Leu Ala Glu His Phe
        355                 360                 365             
Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Asn
    370                 375                 380                 
Ala Phe Ser Lys Lys Ser Tyr Leu Val Val His Gln Arg Thr His Arg
385                 390                 395                 400 
Gly Glu Lys Pro Asn Glu Cys Lys Glu Cys Gly Lys Thr Phe Phe Cys
                405                 410                 415     
Gln Ser Ala Leu Thr Ala His Gln Arg Ile His Thr Gly Glu Lys Pro
            420                 425                 430         
Tyr Glu Cys Ser Glu Cys Glu Lys Thr Phe Phe Cys Gln Ser Ala Leu
        435                 440                 445             
Asn Val His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Ser
    450                 455                 460                 
Gln Cys Gly Lys Phe Leu Cys Thr Lys Ser Ala Leu Ile Ala His Gln
465                 470                 475                 480 
Ile Thr His Arg Gly Lys Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys
                485                 490                 495     
Phe Phe Cys His Lys Ser Thr Leu Thr Ile His Gln Arg Thr His Thr
            500                 505                 510         
Gly Glu Lys His Gly Val Phe Asn Lys Cys Gly Arg Ile Ser Ile Val
        515                 520                 525             
Lys Ser Asn Cys Ser Gln Cys Lys Arg Met Asn Thr Lys Glu Asn Leu
    530                 535                 540                 
Tyr Glu Cys Ser Glu His Gly His Ala Val Ser Lys Asn Ser His Leu
545                 550                 555                 560 
Ile Val His Gln Arg Thr Ile Trp Glu Arg Pro Tyr Glu Cys Asn Glu
                565                 570                 575     
Cys Gly Arg Thr Tyr Cys Arg Lys Ser Ala Leu Thr His His Gln Arg
            580                 585                 590         
Thr His Thr Gly Gln Arg Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr
        595                 600                 605             
Phe Cys Gln Lys Phe Ser Phe Val Glu His Gln Arg Thr His Thr Gly
    610                 615                 620                 
Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe Cys His Lys
625                 630                 635                 640 
Ser Ala Phe Arg Val His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr
                645                 650                 655     
Glu Cys Asn Gln Cys Gly Lys Thr Tyr Arg Arg Leu Trp Thr Leu Thr
            660                 665                 670         
Glu His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys
        675                 680                 685             
Cys Glu Lys Thr Phe Arg His Lys Ser Asn Phe Leu Leu His Gln Lys
    690                 695                 700                 
Ser His Lys Glu
705             


<210> 8372
<211> 634
<212> PRT
<213> Homo sapiens

<400> 8372
Pro Val Ser Phe Gln Asp Leu Thr Val Asn Phe Thr Gln Glu Glu Trp
 1               5                  10                  15      
Gln Gln Leu Asp Pro Ala Gln Arg Leu Leu Tyr Arg Asp Val Met Leu
            20                  25                  30          
Glu Asn Tyr Ser Asn Leu Val Ser Val Glu Lys Asn Lys Glu Ile Gln
        35                  40                  45              
Asp Lys His Leu Thr Gln Thr Val Phe Phe Ser Asn Lys Thr Leu Ile
    50                  55                  60                  
Thr Glu Arg Glu Asn Val Phe Gly Lys Thr Leu Asn Leu Gly Met Asn
65                  70                  75                  80  
Ser Val Pro Ser Arg Lys Met Pro Tyr Lys Cys Asn Pro Gly Gly Asn
                85                  90                  95      
Ser Leu Lys Thr Asn Ser Glu Val Ile Val Ala Lys Lys Ser Lys Glu
            100                 105                 110         
Asn Arg Lys Ile Pro Asp Gly Tyr Ser Gly Phe Gly Lys His Glu Lys
        115                 120                 125             
Ser His Leu Gly Met Lys Lys Tyr Arg Tyr Asn Pro Met Arg Lys Ala
    130                 135                 140                 
Ser Asn Gln Asn Glu Asn Leu Ile Leu His Gln Asn Ile Gln Ile Leu
145                 150                 155                 160 
Lys Gln Pro Phe Asp Tyr Asn Lys Cys Gly Lys Thr Phe Phe Lys Arg
                165                 170                 175     
Ala Ile Leu Ile Thr Gln Lys Gly Arg Gln Thr Glu Arg Lys Pro Asn
            180                 185                 190         
Glu Cys Asn Glu Cys Arg Lys Thr Phe Ser Lys Arg Ser Thr Leu Ile
        195                 200                 205             
Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Ser Asp
    210                 215                 220                 
Cys Arg Lys Thr Phe Arg Val Lys Thr Ser Leu Thr Arg His Arg Arg
225                 230                 235                 240 
Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Arg Lys Thr
                245                 250                 255     
Phe Ile Asp Lys Ser Ala Leu Ile Val His Gln Lys Ile His Gly Gly
            260                 265                 270         
Glu Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Phe Arg Lys
        275                 280                 285             
Ser Ala Leu Ala Glu His Phe Arg Ser His Thr Gly Glu Lys Pro Tyr
    290                 295                 300                 
Glu Cys Lys Glu Cys Gly Asn Ala Phe Ser Lys Lys Ser Tyr Leu Val
305                 310                 315                 320 
Val His Gln Arg Thr His Arg Gly Glu Lys Pro Asn Glu Cys Lys Glu
                325                 330                 335     
Cys Gly Lys Thr Phe Phe Cys Gln Ser Ala Leu Thr Ala His Gln Arg
            340                 345                 350         
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Glu Lys Thr
        355                 360                 365             
Phe Phe Cys Gln Ser Ala Leu Asn Val His Arg Arg Ser His Thr Gly
    370                 375                 380                 
Glu Lys Pro Tyr Glu Cys Ser Gln Cys Gly Lys Phe Leu Cys Thr Lys
385                 390                 395                 400 
Ser Ala Leu Ile Ala His Gln Ile Thr His Arg Gly Lys Lys Ser Tyr
                405                 410                 415     
Glu Cys Asn Glu Cys Gly Lys Phe Phe Cys His Lys Ser Thr Leu Thr
            420                 425                 430         
Ile His Gln Arg Thr His Thr Gly Glu Lys His Gly Val Phe Asn Lys
        435                 440                 445             
Cys Gly Arg Ile Ser Ile Val Lys Ser Asn Cys Ser Gln Cys Lys Arg
    450                 455                 460                 
Met Asn Thr Lys Glu Asn Leu Tyr Glu Cys Ser Glu His Gly His Ala
465                 470                 475                 480 
Val Ser Lys Asn Ser His Leu Ile Val His Gln Arg Thr Ile Trp Glu
                485                 490                 495     
Arg Pro Tyr Glu Cys Asn Glu Cys Gly Arg Thr Tyr Cys Arg Lys Ser
            500                 505                 510         
Ala Leu Thr His His Gln Arg Thr His Thr Gly Gln Arg Pro Tyr Glu
        515                 520                 525             
Cys Asn Glu Cys Gly Lys Thr Phe Cys Gln Lys Phe Ser Phe Val Glu
    530                 535                 540                 
His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys
545                 550                 555                 560 
Gly Lys Ser Phe Cys His Lys Ser Ala Phe Arg Val His Arg Arg Ile
                565                 570                 575     
His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Thr Tyr
            580                 585                 590         
Arg Arg Leu Trp Thr Leu Thr Glu His Gln Lys Ile His Thr Gly Glu
        595                 600                 605             
Lys Pro Tyr Glu Cys Asn Lys Cys Glu Lys Thr Phe Arg His Lys Ser
    610                 615                 620                 
Asn Phe Leu Leu His Gln Lys Ser His Lys
625                 630                 


<210> 8373
<211> 703
<212> PRT
<213> Homo sapiens

<400> 8373
Met Cys Val Phe Leu His Leu Leu Ser Tyr Ile Lys Asp Thr Ser Phe
 1               5                  10                  15      
Ile Pro Gly Pro Asp Cys Glu Leu His Pro Arg Gly Met Ala Ala Thr
            20                  25                  30          
Gly Pro Cys Ser Glu Ala Pro Val Gln Gly Cys Asp Ala Gly Glu Leu
        35                  40                  45              
Gln Gln Leu Gly Leu Cys Gly Val Ser Asp Val Gln Arg Ser Trp Ser
    50                  55                  60                  
Lys Phe Cys Asn Phe Pro Leu Thr Gly Tyr His Val Ser Lys Pro Asp
65                  70                  75                  80  
Val Ile Phe Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile Val Glu Glu
                85                  90                  95      
Phe Ser Asn Gln Asn Tyr Pro Asp Ile Asp Asp Ala Leu Glu Lys Asn
            100                 105                 110         
Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr Val Phe Phe Ser Asn
        115                 120                 125             
Lys Thr Leu Ile Thr Glu Arg Glu Asn Val Phe Gly Lys Thr Leu Asn
    130                 135                 140                 
Leu Gly Met Asn Ser Val Pro Ser Arg Lys Met Pro Tyr Lys Cys Asn
145                 150                 155                 160 
Pro Gly Gly Asn Ser Leu Lys Thr Asn Ser Glu Val Ile Val Ala Lys
                165                 170                 175     
Lys Ser Lys Glu Asn Arg Lys Ile Pro Asp Gly Tyr Ser Gly Phe Gly
            180                 185                 190         
Lys His Glu Lys Ser His Leu Gly Met Lys Lys Tyr Arg Tyr Asn Pro
        195                 200                 205             
Met Arg Lys Ala Ser Asn Gln Asn Glu Asn Leu Ile Leu His Gln Asn
    210                 215                 220                 
Ile Gln Ile Leu Lys Gln Pro Phe Asp Tyr Asn Lys Cys Gly Lys Thr
225                 230                 235                 240 
Phe Phe Lys Arg Ala Ile Leu Ile Thr Gln Lys Gly Arg Gln Thr Glu
                245                 250                 255     
Arg Lys Pro Asn Glu Cys Asn Glu Cys Arg Lys Thr Phe Ser Lys Arg
            260                 265                 270         
Ser Thr Leu Ile Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
        275                 280                 285             
Val Cys Ser Asp Cys Arg Lys Thr Phe Arg Val Lys Thr Ser Leu Thr
    290                 295                 300                 
Arg His Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu
305                 310                 315                 320 
Cys Arg Lys Thr Phe Ile Asp Lys Ser Ala Leu Ile Val His Gln Lys
                325                 330                 335     
Ile His Gly Gly Glu Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Thr
            340                 345                 350         
Phe Phe Arg Lys Ser Ala Leu Ala Glu His Phe Arg Ser His Thr Gly
        355                 360                 365             
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Asn Ala Phe Ser Lys Lys
    370                 375                 380                 
Ser Tyr Leu Val Val His Gln Arg Thr His Arg Gly Glu Lys Pro Asn
385                 390                 395                 400 
Glu Cys Lys Glu Cys Gly Lys Thr Phe Phe Cys Gln Ser Ala Leu Thr
                405                 410                 415     
Ala His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu
            420                 425                 430         
Cys Glu Lys Thr Phe Phe Cys Gln Ser Ala Leu Asn Val His Arg Arg
        435                 440                 445             
Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Gln Cys Gly Lys Phe
    450                 455                 460                 
Leu Cys Thr Lys Ser Ala Leu Ile Ala His Gln Ile Thr His Arg Gly
465                 470                 475                 480 
Lys Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Cys His Lys
                485                 490                 495     
Ser Thr Leu Thr Ile His Gln Arg Thr His Thr Gly Glu Lys His Gly
            500                 505                 510         
Val Phe Asn Lys Cys Gly Arg Ile Ser Ile Val Lys Ser Asn Cys Ser
        515                 520                 525             
Gln Cys Lys Arg Met Asn Thr Lys Glu Asn Leu Tyr Glu Cys Ser Glu
    530                 535                 540                 
His Gly His Ala Val Ser Lys Asn Ser His Leu Ile Val His Gln Arg
545                 550                 555                 560 
Thr Ile Trp Glu Arg Pro Tyr Glu Cys Asn Glu Cys Gly Arg Thr Tyr
                565                 570                 575     
Cys Arg Lys Ser Ala Leu Thr His His Gln Arg Thr His Thr Gly Gln
            580                 585                 590         
Arg Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Cys Gln Lys Phe
        595                 600                 605             
Ser Phe Val Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu
    610                 615                 620                 
Cys Asn Glu Cys Gly Lys Ser Phe Cys His Lys Ser Ala Phe Arg Val
625                 630                 635                 640 
His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys
                645                 650                 655     
Gly Lys Thr Tyr Arg Arg Leu Trp Thr Leu Thr Glu His Gln Lys Ile
            660                 665                 670         
His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Glu Lys Thr Phe
        675                 680                 685             
Arg His Lys Ser Asn Phe Leu Leu His Gln Lys Ser His Lys Glu
    690                 695                 700             


<210> 8374
<211> 587
<212> PRT
<213> Homo sapiens

<400> 8374
Val Ser Phe Gln Asp Leu Thr Val Asn Phe Thr Gln Glu Glu Trp Gln
 1               5                  10                  15      
Gln Leu Asp Pro Ala Gln Arg Leu Leu Tyr Arg Asp Val Met Leu Glu
            20                  25                  30          
Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr His Val Ser Lys Pro Asp
        35                  40                  45              
Val Ile Phe Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile Val Glu Glu
    50                  55                  60                  
Phe Ser Asn Gln Asn Tyr Pro Asp Ile Asp Asp Ala Leu Glu Lys Asn
65                  70                  75                  80  
Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr Val Phe Phe Ser Asn
                85                  90                  95      
Lys Thr Leu Ile Thr Glu Arg Glu Asn Val Phe Gly Lys Thr Leu Asn
            100                 105                 110         
Leu Gly Met Asn Ser Val Pro Ser Arg Lys Met Pro Tyr Lys Cys Asn
        115                 120                 125             
Pro Gly Gly Asn Ser Leu Lys Thr Asn Ser Glu Val Ile Val Ala Lys
    130                 135                 140                 
Lys Ser Lys Glu Asn Arg Lys Ile Pro Asp Gly Tyr Ser Gly Phe Gly
145                 150                 155                 160 
Lys His Glu Lys Ser His Leu Gly Met Lys Lys Tyr Arg Tyr Asn Pro
                165                 170                 175     
Met Arg Lys Ala Ser Asn Gln Asn Glu Asn Leu Ile Leu His Gln Asn
            180                 185                 190         
Ile Gln Ile Leu Lys Gln Pro Phe Asp Tyr Asn Lys Cys Gly Lys Thr
        195                 200                 205             
Phe Phe Lys Arg Ala Ile Leu Ile Thr Gln Lys Gly Arg Gln Thr Glu
    210                 215                 220                 
Arg Lys Pro Asn Glu Cys Asn Glu Cys Arg Lys Thr Phe Ser Lys Arg
225                 230                 235                 240 
Ser Thr Leu Ile Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr
                245                 250                 255     
Val Cys Ser Asp Cys Arg Lys Thr Phe Arg Val Lys Thr Ser Leu Thr
            260                 265                 270         
Arg His Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu
        275                 280                 285             
Cys Arg Lys Thr Phe Ile Asp Lys Ser Ala Leu Ile Val His Gln Lys
    290                 295                 300                 
Ile His Gly Gly Glu Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Thr
305                 310                 315                 320 
Phe Phe Arg Lys Ser Ala Leu Ala Glu His Phe Arg Ser His Thr Gly
                325                 330                 335     
Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Asn Ala Phe Ser Lys Lys
            340                 345                 350         
Ser Tyr Leu Val Val His Gln Arg Thr His Arg Gly Glu Lys Pro Asn
        355                 360                 365             
Glu Cys Lys Glu Cys Gly Lys Thr Phe Phe Cys Gln Ser Ala Leu Thr
    370                 375                 380                 
Ala His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu
385                 390                 395                 400 
Cys Glu Lys Thr Phe Phe Cys Gln Ser Ala Leu Asn Val His Arg Arg
                405                 410                 415     
Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Gln Cys Gly Lys Phe
            420                 425                 430         
Leu Cys Thr Lys Ser Ala Leu Ile Ala His Gln Ile Thr His Arg Gly
        435                 440                 445             
Lys Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Cys His Lys
    450                 455                 460                 
Lys Ser Ala Leu Thr His His Gln Arg Thr His Thr Gly Gln Arg Pro
465                 470                 475                 480 
Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Cys Gln Lys Phe Ser Phe
                485                 490                 495     
Val Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn
            500                 505                 510         
Glu Cys Gly Lys Ser Phe Cys His Lys Ser Ala Phe Arg Val His Arg
        515                 520                 525             
Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys
    530                 535                 540                 
Thr Tyr Arg Arg Leu Trp Thr Leu Thr Glu His Gln Lys Ile His Thr
545                 550                 555                 560 
Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Glu Lys Thr Phe Arg His
                565                 570                 575     
Lys Ser Asn Phe Leu Leu His Gln Lys Ser His
            580                 585         


<210> 8375
<211> 195
<212> PRT
<213> Homo sapiens

<400> 8375
Met Leu Lys Thr Leu Asn Lys Leu Gly Ile Glu Gly Pro Cys Leu Lys
 1               5                  10                  15      
Ile Ile Arg Ala Ile Cys Asp Lys Arg Thr Ala Asn Ile Ile Leu Asn
            20                  25                  30          
Gly Gln Gln Leu Glu Ala Phe Pro Leu Lys Thr Gly Thr Arg Gln Gly
        35                  40                  45              
Cys Pro Leu Ser Pro Leu Leu Phe Asn Ile Val Leu Glu Val Leu Ala
    50                  55                  60                  
Arg Ala Ile Arg Gln Val Lys Glu Ile Lys Gly Ile Gln Ile Gly Arg
65                  70                  75                  80  
Glu Glu Val Asn Leu Ser Leu Leu Ala Asp Asp Met Ile Leu Tyr Leu
                85                  90                  95      
Glu Asn Pro Val Val Ser Ala Gln Arg Pro Leu Lys Leu Ile Asn Asn
            100                 105                 110         
Phe Ser Lys Val Ser Gly Tyr Arg Ile Asn Val Gln Lys Ser Leu Ala
        115                 120                 125             
Phe Leu Tyr Thr Ser Asn Ser Lys Ala Asp Ser Gln Ile Ser Asn Glu
    130                 135                 140                 
Leu Pro Phe Thr Ile Ala Thr Lys Arg Ile Lys Tyr Leu Gly Ile Gln
145                 150                 155                 160 
Leu Thr Arg Glu Val Lys Asp Leu Tyr Lys Glu Asn Tyr Lys Pro Pro
                165                 170                 175     
Leu Lys Glu Ile Gly Asp Asp Thr Gln Lys Asn Gly Lys Thr Phe Gln
            180                 185                 190         
Ala His Gly
        195 


<210> 8376
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 8376
Met Phe Gln Leu Pro Val Asn Asn Leu Gly Ser Leu Arg Lys Ala Arg
 1               5                  10                  15      
Lys Thr Val Lys Lys Ile Leu Ser Asp Ile Gly Leu Glu Tyr Cys Lys
            20                  25                  30          
Glu His Ile Glu Asp Phe Lys Gln Phe Glu Pro Asn Asp Phe Tyr Leu
        35                  40                  45              
Lys Asn Thr Thr Trp Glu Asp Val Gly Leu Trp Asp Pro Ser Leu Thr
    50                  55                  60                  
Lys Asn Gln Asp Tyr Arg Thr Lys Pro Phe Cys Cys Ser Ala Cys Pro
65                  70                  75                  80  
Phe Ser Ser Lys Phe Phe Ser Ala Tyr Lys Ser His Phe Arg Asn Val
                85                  90                  95      
His Ser Glu Asp Phe Glu Asn Arg Ile Leu Leu Asn Cys Pro Tyr Cys
            100                 105                 110         
Thr Phe Asn Ala Asp Lys Lys Thr Leu Glu Thr His Ile Lys Ile Phe
        115                 120                 125             
His Ala Pro Asn Ala Ser Ala Pro Ser Ser Ser Leu Ser Thr Phe Lys
    130                 135                 140                 
Asp Lys Asn Lys Asn Asp Gly Leu Lys Pro Lys Gln Ala Asp Ser Val
145                 150                 155                 160 
Glu Gln Ala Val Tyr Tyr Cys Lys Lys Cys Thr Tyr Arg Asp Pro Leu
                165                 170                 175     
Tyr Glu Ile Val Arg Lys His Ile Tyr Arg Glu His Phe Gln His Val
            180                 185                 190         
Ala Ala Pro Tyr Ile Ala Lys Ala Gly Glu Lys Ser Leu Asn Gly Ala
        195                 200                 205             
Val Pro Leu Gly Ser Asn Ala Arg Glu Glu Ser Ser Ile His Cys Lys
    210                 215                 220                 
Arg Cys Leu Phe Met Pro Lys Ser Tyr Glu Ala Leu Val Gln His Val
225                 230                 235                 240 
Ile Glu Asp His Glu Arg Ile Gly Tyr Gln Val Thr Ala Met Ile Gly
                245                 250                 255     
His Thr Asn Val Val Val Pro Arg Ser Lys Pro Leu Met Leu Ile Ala
            260                 265                 270         
Pro Lys Pro Gln Asp Lys Lys Ser Met Gly Leu Pro Pro Arg Ile Gly
        275                 280                 285             
Ser Leu Ala Ser Gly Asn Val Arg Ser Leu Pro Ser Gln Gln Met Val
    290                 295                 300                 
Asn Arg Leu Ser Ile Pro Lys Pro Asn Leu Asn Ser Thr Gly Val Asn
305                 310                 315                 320 
Met Met Ser Ser Val His Leu Gln Gln Asn Asn Tyr Gly Val Lys Ser
                325                 330                 335     
Val Gly Gln Gly Tyr Ser Val Gly Gln Ser Met Arg Leu Gly Leu Gly
            340                 345                 350         
Gly Asn Ala Pro Val Ser Ile Pro Gln Gln Ser Gln Ser Val Lys Gln
        355                 360                 365             
Leu Leu Pro Ser Gly Asn Gly Arg Ser Tyr Gly Leu Gly Ser Glu Gln
    370                 375                 380                 
Arg Ser Gln Ala Pro Ala Arg Tyr Ser Leu Gln Ser Ala Asn Ala Ser
385                 390                 395                 400 
Ser Leu Ser Ser Gly Gln Leu Lys Ser Pro Ser Leu Ser Gln Ser Gln
                405                 410                 415     
Ala Ser Arg Val Leu Gly Gln Ser Ser Ser Lys Pro Ala Ala Ala Ala
            420                 425                 430         
Thr Gly Pro Pro Pro Gly Asn Thr Ser Ser Thr Gln Lys Trp Lys Ile
        435                 440                 445             
Cys Thr Ile Cys Asn Glu Leu Phe Pro Glu Asn Val Tyr Ser Val His
    450                 455                 460                 
Phe Glu Lys Glu His Lys Ala Glu Lys Val Pro Ala Val Ala Asn Tyr
465                 470                 475                 480 
Ile Met Lys Ile His Asn Phe Thr Ser Lys Cys Leu Tyr Cys Asn Arg
                485                 490                 495     
Tyr Leu Pro Thr Asp Thr Leu Leu Asn His Met Leu Ile His Gly Leu
            500                 505                 510         
Ser Cys Pro Tyr Cys Arg Ser Thr Phe Asn Asp Val Glu Lys Met Ala
        515                 520                 525             
Ala His Met Arg Met Val His Ile Asp Glu Glu Met Gly Pro Lys Thr
    530                 535                 540                 
Asp Ser Thr Leu Ser Phe Asp Leu Thr Leu Gln Gln Gly Ser His Thr
545                 550                 555                 560 
Asn Ile His Leu Leu Val Thr Thr Tyr Asn Leu Arg Asp Ala Pro Ala
                565                 570                 575     
Glu Ser Val Ala Tyr His Ala Gln Asn Asn Pro Pro Val Pro Pro Lys
            580                 585                 590         
Pro Gln Pro Lys Val Gln Glu Lys Ala Asp Ile Pro Val Lys Ser Ser
        595                 600                 605             
Pro Gln Ala Ala Val Pro Tyr Lys Lys Asp Val Gly Lys Thr Leu Cys
    610                 615                 620                 
Pro Leu Cys Phe Ser Ile Leu Lys Gly Pro Ile Ser Asp Ala Leu Ala
625                 630                 635                 640 
His His Leu Arg Glu Arg His Gln Val Ile Gln Thr Val His Pro Val
                645                 650                 655     
Glu Lys Lys Leu Thr Tyr Lys Cys Ile His Cys Leu Gly Val Tyr Thr
            660                 665                 670         
Ser Asn Met Thr Ala Ser Thr Ile Thr Leu His Leu Val His Cys Arg
        675                 680                 685             
Gly Val Gly Lys Thr Gln Asn Gly Gln Asp Lys Thr Asn Ala Pro Ser
    690                 695                 700                 
Arg Leu Asn Gln Ser Pro Ser Leu Ala Pro Val Lys Arg Thr Tyr Glu
705                 710                 715                 720 
Gln Met Glu Phe Pro Leu Leu Lys Lys Arg Lys Leu Asp Asp Asp Ser
                725                 730                 735     
Asp Ser Pro Ser Phe Phe Glu Glu Lys Pro Glu Glu Pro Val Val Leu
            740                 745                 750         
Ala Leu Asp Pro Lys Gly His Glu Asp Asp Ser Tyr Glu Ala Arg Lys
        755                 760                 765             
Ser Phe Leu Thr Lys Tyr Phe Asn Lys Gln Pro Tyr Pro Thr Arg Arg
    770                 775                 780                 
Glu Ile Glu Lys Leu Ala Ala Ser Leu Trp Leu Trp Lys Ser Asp Ile
785                 790                 795                 800 
Ala Ser His Phe Ser Asn Lys Arg Lys Lys Cys Val Arg Asp Cys Glu
                805                 810                 815     
Lys Tyr Lys Pro Gly Val Leu Leu Gly Phe Asn Met Lys Glu Leu Asn
            820                 825                 830         
Lys Val Lys His Glu Met Asp Phe Asp Ala Glu Trp Leu Phe Glu Asn
        835                 840                 845             
His Asp Glu Lys Asp Ser Arg Val Asn Ala Ser Lys Thr Ala Asp Lys
    850                 855                 860                 
Lys Leu Asn Leu Gly Lys Glu Asp Asp Ser Ser Ser Asp Ser Phe Glu
865                 870                 875                 880 
Asn Leu Glu Glu Glu Ser Asn Glu Ser Gly Ser Pro Phe Asp Pro Val
                885                 890                 895     
Phe Glu Val Glu Pro Lys Ile Ser Asn Asp Asn Pro Glu Glu His Val
            900                 905                 910         
Leu Lys Val Ile Pro Glu Asp Ala Ser Glu Ser Glu Glu Lys Leu Asp
        915                 920                 925             
Gln Lys Glu Asp Gly Ser Lys Tyr Glu Thr Ile His Leu Thr Glu Glu
    930                 935                 940                 
Pro Thr Lys Leu Met His Asn Ala Ser Asp Ser Glu Val Asp Gln Asp
945                 950                 955                 960 
Asp Val Val Glu Trp Lys Asp Gly Ala Ser Pro Ser Glu Ser Gly Pro
                965                 970                 975     
Gly Ser Gln Gln Val Ser Asp Phe Glu Asp Asn Thr Cys Glu Met Lys
            980                 985                 990         
Pro Gly Thr Trp Ser Asp Glu Ser Ser Gln Ser Glu Asp Ala Arg Ser
        995                 1000                1005            
Ser Lys Pro Ala Ala Lys Lys Lys Ala Thr Met Gln Gly Asp Arg Glu
    1010                1015                1020                
Gln Leu Lys Trp Lys Asn Ser Ser Tyr Gly Lys Val Glu Gly Phe Trp
1025                1030                1035                1040
Ser Lys Asp Gln Ser Gln Trp Lys Asn Ala Ser Glu Asn Asp Glu Arg
                1045                1050                1055    
Leu Ser Asn Pro Gln Ile Glu Trp Gln Asn Ser Thr Ile Asp Ser Glu
            1060                1065                1070        
Asp Gly Glu Gln Phe Asp Asn Met Thr Asp Gly Val Ala Glu Pro Met
        1075                1080                1085            
His Gly Ser Leu Ala Gly Val Lys Leu Ser Ser Gln Gln Ala
    1090                1095                1100        


<210> 8377
<211> 2062
<212> PRT
<213> Homo sapiens

<400> 8377
Met Pro Lys Ser Gly Phe Thr Lys Pro Ile Gln Ser Glu Asn Ser Asp
 1               5                  10                  15      
Ser Asp Ser Asn Met Val Glu Lys Pro Tyr Gly Arg Lys Ser Lys Asp
            20                  25                  30          
Lys Ile Ala Ser Tyr Ser Lys Thr Pro Lys Ile Glu Arg Ser Asp Val
        35                  40                  45              
Ser Lys Glu Met Lys Glu Lys Ser Ser Met Lys Arg Lys Leu Pro Phe
    50                  55                  60                  
Thr Ile Ser Pro Ser Arg Asn Glu Glu Arg Asp Ser Asp Thr Asp Ser
65                  70                  75                  80  
Asp Pro Gly His Thr Ser Glu Asn Trp Gly Glu Arg Leu Ile Ser Ser
                85                  90                  95      
Tyr Arg Thr Tyr Ser Glu Lys Glu Gly Pro Glu Lys Lys Lys Thr Lys
            100                 105                 110         
Lys Glu Ala Gly Asn Lys Lys Ser Thr Pro Val Ser Ile Leu Phe Gly
        115                 120                 125             
Tyr Pro Leu Ser Glu Arg Lys Gln Met Ala Leu Leu Met Gln Met Thr
    130                 135                 140                 
Ala Arg Asp Asn Ser Pro Asp Ser Thr Pro Asn His Pro Ser Gln Thr
145                 150                 155                 160 
Thr Pro Ala Gln Lys Lys Thr Pro Ser Ser Ser Ser Arg Gln Lys Asp
                165                 170                 175     
Lys Val Asn Lys Arg Asn Glu Arg Gly Glu Thr Pro Leu His Met Ala
            180                 185                 190         
Ala Ile Arg Gly Asp Val Lys Gln Val Lys Glu Leu Ile Ser Leu Gly
        195                 200                 205             
Ala Asn Val Asn Val Lys Asp Phe Ala Gly Trp Thr Pro Leu His Glu
    210                 215                 220                 
Ala Cys Asn Val Gly Tyr Tyr Asp Val Ala Lys Ile Leu Ile Ala Ala
225                 230                 235                 240 
Gly Ala Asp Val Asn Thr Gln Gly Leu Asp Asp Asp Thr Pro Leu His
                245                 250                 255     
Asp Ser Ala Ser Ser Gly His Arg Asp Ile Val Lys Leu Leu Leu Arg
            260                 265                 270         
His Gly Gly Asn Pro Phe Gln Ala Asn Lys His Gly Glu Arg Pro Val
        275                 280                 285             
Asp Val Ala Glu Thr Glu Glu Leu Glu Leu Leu Leu Lys Arg Glu Val
    290                 295                 300                 
Pro Leu Ser Asp Asp Asp Glu Ser Tyr Thr Asp Ser Glu Glu Ala Gln
305                 310                 315                 320 
Ser Val Asn Pro Ser Ser Val Asp Glu Asn Ile Asp Ser Glu Thr Glu
                325                 330                 335     
Lys Asp Ser Leu Ile Cys Glu Ser Lys Gln Ile Leu Pro Ser Lys Thr
            340                 345                 350         
Pro Leu Pro Ser Ala Leu Asp Glu Tyr Glu Phe Lys Asp Asp Asp Asp
        355                 360                 365             
Glu Glu Ile Asn Lys Met Ile Asp Asp Arg His Ile Leu Arg Lys Glu
    370                 375                 380                 
Gln Arg Lys Glu Asn Glu Pro Glu Ala Glu Lys Thr His Leu Phe Ala
385                 390                 395                 400 
Lys Gln Glu Lys Ala Phe Tyr Pro Lys Ser Phe Lys Ser Lys Lys Gln
                405                 410                 415     
Lys Pro Ser Arg Val Leu Tyr Ser Ser Thr Glu Ser Ser Asp Glu Glu
            420                 425                 430         
Ala Leu Gln Asn Lys Lys Ile Ser Thr Ser Cys Ser Val Ile Pro Glu
        435                 440                 445             
Thr Ser Asn Ser Asp Met Gln Thr Lys Lys Glu Tyr Val Val Ser Gly
    450                 455                 460                 
Glu His Lys Gln Lys Gly Lys Val Lys Arg Lys Leu Lys Asn Gln Asn
465                 470                 475                 480 
Lys Asn Lys Glu Asn Gln Glu Leu Lys Gln Glu Lys Glu Gly Lys Glu
                485                 490                 495     
Asn Thr Arg Ile Thr Asn Leu Thr Val Asn Thr Gly Leu Asp Cys Ser
            500                 505                 510         
Glu Lys Thr Arg Glu Glu Gly Asn Phe Arg Lys Ser Phe Ser Pro Lys
        515                 520                 525             
Asp Asp Thr Ser Leu His Leu Phe His Ile Ser Thr Gly Lys Ser Pro
    530                 535                 540                 
Lys His Ser Cys Gly Leu Ser Glu Lys Gln Ser Thr Pro Leu Lys Gln
545                 550                 555                 560 
Glu His Thr Lys Thr Cys Leu Ser Pro Gly Ser Ser Glu Met Ser Leu
                565                 570                 575     
Gln Pro Asp Leu Val Arg Tyr Asp Asn Thr Glu Ser Glu Phe Leu Pro
            580                 585                 590         
Glu Ser Ser Ser Val Lys Ser Cys Lys His Lys Glu Lys Ser Lys His
        595                 600                 605             
Gln Lys Asp Phe His Leu Glu Phe Gly Glu Lys Ser Asn Ala Lys Ile
    610                 615                 620                 
Lys Asp Glu Asp His Ser Pro Thr Phe Glu Asn Ser Asp Cys Thr Leu
625                 630                 635                 640 
Lys Lys Met Asp Lys Glu Gly Lys Thr Leu Lys Lys His Lys Leu Lys
                645                 650                 655     
His Lys Glu Arg Glu Lys Glu Lys His Lys Lys Glu Ile Glu Gly Glu
            660                 665                 670         
Lys Glu Lys Tyr Lys Thr Lys Asp Ser Ala Lys Glu Leu Gln Arg Ser
        675                 680                 685             
Val Glu Phe Asp Arg Glu Phe Trp Lys Glu Asn Phe Phe Lys Ser Asp
    690                 695                 700                 
Glu Thr Glu Asp Leu Phe Leu Asn Met Glu His Glu Ser Leu Thr Leu
705                 710                 715                 720 
Glu Lys Lys Ser Lys Leu Glu Lys Asn Ile Lys Asp Asp Lys Ser Thr
                725                 730                 735     
Lys Glu Lys His Val Ser Lys Glu Arg Asn Phe Lys Glu Glu Arg Asp
            740                 745                 750         
Lys Ile Lys Lys Glu Ser Glu Lys Ser Phe Arg Glu Glu Lys Ile Lys
        755                 760                 765             
Asp Leu Lys Glu Glu Arg Glu Asn Ile Pro Thr Asp Lys Asp Ser Glu
    770                 775                 780                 
Phe Thr Ser Leu Gly Met Ser Ala Ile Glu Glu Ser Ile Gly Leu His
785                 790                 795                 800 
Leu Val Glu Lys Glu Ile Asp Ile Glu Lys Gln Glu Lys His Ile Lys
                805                 810                 815     
Glu Ser Lys Glu Lys Pro Glu Lys Arg Ser Gln Ile Lys Glu Lys Asp
            820                 825                 830         
Ile Glu Lys Met Glu Arg Lys Thr Phe Glu Lys Glu Lys Lys Ile Lys
        835                 840                 845             
His Glu His Lys Ser Glu Lys Asp Lys Leu Asp Leu Ser Glu Cys Val
    850                 855                 860                 
Asp Lys Ile Lys Glu Lys Asp Lys Leu Tyr Ser His His Thr Glu Lys
865                 870                 875                 880 
Cys His Lys Glu Gly Glu Lys Ser Lys Asn Thr Ala Ala Ile Lys Lys
                885                 890                 895     
Thr Asp Asp Arg Glu Lys Ser Arg Glu Lys Met Asp Arg Lys His Asp
            900                 905                 910         
Lys Glu Lys Pro Glu Lys Glu Arg His Leu Ala Glu Ser Lys Glu Lys
        915                 920                 925             
His Leu Met Glu Lys Lys Asn Lys Gln Ser Asp Asn Ser Glu Tyr Ser
    930                 935                 940                 
Lys Ser Glu Lys Gly Lys Asn Lys Glu Lys Asp Arg Glu Leu Asp Lys
945                 950                 955                 960 
Lys Glu Lys Ser Arg Asp Lys Glu Ser Ile Asn Ile Thr Asn Ser Lys
                965                 970                 975     
His Ile Gln Glu Glu Lys Lys Ser Ser Ile Val Asp Gly Asn Lys Ala
            980                 985                 990         
Gln His Glu Lys Pro Leu Ser Leu Lys Glu Lys Thr Lys Asp Glu Pro
        995                 1000                1005            
Leu Lys Thr Pro Asp Gly Lys Glu Lys Asp Lys Lys Asp Lys Asp Ile
    1010                1015                1020                
Asp Arg Tyr Lys Glu Arg Asp Lys His Lys Asp Lys Ile Gln Ile Asn
1025                1030                1035                1040
Ser Leu Leu Lys Leu Lys Ser Glu Ala Asp Lys Pro Lys Pro Lys Ser
                1045                1050                1055    
Ser Pro Ala Ser Lys Asp Thr Arg Pro Lys Glu Lys Arg Leu Val Asn
            1060                1065                1070        
Asp Asp Leu Met Gln Thr Ser Phe Glu Arg Met Leu Ser Leu Lys Asp
        1075                1080                1085            
Leu Glu Ile Glu Gln Trp His Lys Lys His Lys Glu Lys Ile Lys Gln
    1090                1095                1100                
Lys Glu Lys Glu Arg Leu Arg Asn Arg Asn Cys Leu Glu Leu Lys Ile
1105                1110                1115                1120
Lys Asp Lys Glu Lys Thr Lys His Thr Pro Thr Glu Ser Lys Asn Lys
                1125                1130                1135    
Glu Leu Thr Arg Ser Lys Ser Ser Glu Val Thr Asp Ala Tyr Thr Lys
            1140                1145                1150        
Glu Lys Gln Pro Lys Asp Ala Val Ser Asn Arg Ser Gln Ser Val Asp
        1155                1160                1165            
Thr Lys Asn Val Met Thr Leu Gly Lys Ser Ser Phe Val Ser Asp Asn
    1170                1175                1180                
Ser Leu Asn Arg Ser Pro Arg Ser Glu Asn Glu Lys Pro Gly Leu Ser
1185                1190                1195                1200
Ser Arg Ser Val Ser Met Ile Ser Val Ala Ser Ser Glu Asp Ser Cys
                1205                1210                1215    
His Thr Thr Val Thr Thr Pro Arg Pro Pro Val Glu Tyr Asp Ser Asp
            1220                1225                1230        
Phe Met Leu Glu Ser Ser Glu Ser Gln Met Ser Phe Ser Gln Ser Pro
        1235                1240                1245            
Phe Leu Ser Ile Ala Lys Ser Pro Ala Leu His Glu Arg Glu Leu Asp
    1250                1255                1260                
Ser Leu Ala Asp Leu Pro Glu Arg Ile Lys Pro Pro Tyr Ala Asn Arg
1265                1270                1275                1280
Leu Ser Thr Ser His Leu Arg Ser Ser Ser Val Glu Asp Val Lys Leu
                1285                1290                1295    
Ile Ile Ser Glu Gly Arg Pro Thr Ile Glu Val Arg Arg Cys Ser Met
            1300                1305                1310        
Pro Ser Val Ile Cys Glu His Thr Lys Gln Phe Gln Thr Ile Ser Glu
        1315                1320                1325            
Glu Ser Asn Gln Gly Ser Leu Leu Thr Val Pro Gly Asp Thr Ser Pro
    1330                1335                1340                
Ser Pro Lys Pro Glu Val Phe Ser Asn Val Pro Glu Arg Asp Leu Ser
1345                1350                1355                1360
Asn Val Ser Asn Ile His Ser Ser Phe Ala Thr Ser Pro Thr Gly Ala
                1365                1370                1375    
Ser Asn Ser Lys Tyr Val Ser Ala Asp Arg Asn Leu Ile Lys Asn Thr
            1380                1385                1390        
Ala Pro Val Asn Thr Val Met Asp Ser Pro Val His Leu Glu Pro Ser
        1395                1400                1405            
Ser Gln Val Gly Val Ile Gln Asn Lys Ser Trp Glu Met Pro Val Asp
    1410                1415                1420                
Arg Leu Glu Thr Leu Ser Thr Arg Asp Phe Ile Cys Pro Asn Ser Asn
1425                1430                1435                1440
Ile Pro Asp Gln Glu Ser Ser Leu Gln Ser Phe Cys Asn Ser Glu Asn
                1445                1450                1455    
Lys Val Leu Lys Glu Asn Ala Asp Phe Leu Ser Leu Arg Gln Thr Glu
            1460                1465                1470        
Leu Pro Gly Asn Ser Cys Ala Gln Asp Pro Ala Ser Phe Met Pro Pro
        1475                1480                1485            
Gln Gln Pro Cys Ser Phe Pro Ser Gln Ser Leu Ser Asp Ala Glu Ser
    1490                1495                1500                
Ile Ser Lys His Met Ser Leu Ser Tyr Val Ala Asn Gln Glu Pro Gly
1505                1510                1515                1520
Ile Leu Gln Gln Lys Asn Ala Val Gln Ile Ile Ser Ser Ala Leu Asp
                1525                1530                1535    
Thr Asp Asn Glu Ser Thr Lys Asp Thr Glu Asn Thr Phe Val Leu Gly
            1540                1545                1550        
Asp Val Gln Lys Thr Asp Ala Phe Val Pro Val Tyr Ser Asp Ser Thr
        1555                1560                1565            
Ile Gln Glu Ala Ser Pro Asn Phe Glu Lys Ala Tyr Thr Leu Pro Val
    1570                1575                1580                
Leu Pro Ser Glu Lys Asp Phe Asn Gly Ser Asp Ala Ser Thr Gln Leu
1585                1590                1595                1600
Asn Thr His Tyr Ala Phe Ser Lys Leu Thr Tyr Lys Ser Ser Ser Gly
                1605                1610                1615    
His Glu Val Glu Asn Ser Thr Thr Asp Thr Gln Val Ile Ser His Glu
            1620                1625                1630        
Lys Glu Asn Lys Leu Glu Ser Leu Val Leu Thr His Leu Ser Arg Cys
        1635                1640                1645            
Asp Ser Asp Leu Cys Glu Met Asn Ala Gly Met Pro Lys Gly Asn Leu
    1650                1655                1660                
Asn Glu Gln Asp Pro Lys His Cys Pro Glu Ser Glu Lys Cys Leu Leu
1665                1670                1675                1680
Ser Ile Glu Asp Glu Glu Ser Gln Gln Ser Ile Leu Ser Ser Leu Glu
                1685                1690                1695    
Asn His Ser Gln Gln Ser Thr Gln Pro Glu Met His Lys Tyr Gly Gln
            1700                1705                1710        
Leu Val Lys Val Glu Leu Glu Glu Asn Ala Glu Asp Asp Lys Thr Glu
        1715                1720                1725            
Asn Gln Ile Pro Gln Arg Met Thr Arg Asn Lys Ala Asn Thr Met Ala
    1730                1735                1740                
Asn Gln Ser Lys Gln Ile Leu Ala Ser Cys Thr Leu Leu Ser Glu Lys
1745                1750                1755                1760
Asp Ser Glu Ser Ser Ser Pro Arg Gly Arg Ile Arg Leu Thr Glu Asp
                1765                1770                1775    
Asp Asp Pro Gln Ile His His Pro Arg Lys Arg Lys Val Ser Arg Val
            1780                1785                1790        
Pro Gln Pro Val Gln Val Ser Pro Ser Leu Leu Gln Ala Lys Glu Lys
        1795                1800                1805            
Thr Gln Gln Ser Leu Ala Ala Ile Val Asp Ser Leu Lys Leu Asp Glu
    1810                1815                1820                
Ile Gln Pro Tyr Ser Ser Glu Arg Ala Asn Pro Tyr Phe Glu Tyr Leu
1825                1830                1835                1840
His Ile Arg Lys Lys Ile Glu Glu Lys Arg Lys Leu Leu Cys Ser Val
                1845                1850                1855    
Ile Pro Gln Ala Pro Gln Tyr Tyr Asp Glu Tyr Val Thr Phe Asn Gly
            1860                1865                1870        
Ser Tyr Leu Leu Asp Gly Asn Pro Leu Ser Lys Ile Cys Ile Pro Thr
        1875                1880                1885            
Ile Thr Pro Pro Pro Ser Leu Ser Asp Pro Leu Lys Glu Leu Phe Arg
    1890                1895                1900                
Gln Gln Glu Val Val Arg Met Lys Leu Arg Leu Gln His Ser Ile Glu
1905                1910                1915                1920
Arg Glu Lys Leu Ile Val Ser Asn Glu Gln Glu Val Leu Arg Val His
                1925                1930                1935    
Tyr Arg Ala Ala Arg Thr Leu Ala Asn Gln Thr Leu Pro Phe Ser Ala
            1940                1945                1950        
Cys Thr Val Leu Leu Asp Ala Glu Val Tyr Asn Val Pro Leu Asp Ser
        1955                1960                1965            
Gln Ser Asp Asp Ser Lys Thr Ser Val Arg Asp Arg Phe Asn Ala Arg
    1970                1975                1980                
Gln Phe Met Ser Trp Leu Gln Asp Val Asp Asp Lys Phe Asp Lys Leu
1985                1990                1995                2000
Lys Thr Cys Leu Leu Met Arg Gln Gln His Glu Ala Ala Ala Leu Asn
                2005                2010                2015    
Ala Val Gln Arg Leu Glu Trp Gln Leu Lys Leu Gln Glu Leu Asp Pro
            2020                2025                2030        
Ala Thr Tyr Lys Ser Ile Ser Ile Tyr Glu Ile Gln Glu Phe Tyr Val
        2035                2040                2045            
Pro Leu Val Asp Val Asn Asp Asp Phe Glu Leu Thr Pro Ile
    2050                2055                2060        


<210> 8378
<211> 1049
<212> PRT
<213> Homo sapiens

<400> 8378
Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly
 1               5                  10                  15      
Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile
            20                  25                  30          
Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe
        35                  40                  45              
Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly
    50                  55                  60                  
Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala
65                  70                  75                  80  
Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr
                85                  90                  95      
Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser
            100                 105                 110         
Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro
        115                 120                 125             
Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys
    130                 135                 140                 
Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys
145                 150                 155                 160 
Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys
                165                 170                 175     
Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe
            180                 185                 190         
Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser
        195                 200                 205             
Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu
    210                 215                 220                 
Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg
225                 230                 235                 240 
Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala
                245                 250                 255     
Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly
            260                 265                 270         
Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val
        275                 280                 285             
Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln
    290                 295                 300                 
His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly
305                 310                 315                 320 
Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys
                325                 330                 335     
Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys
            340                 345                 350         
Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe
        355                 360                 365             
Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys
    370                 375                 380                 
Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp
385                 390                 395                 400 
Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly
                405                 410                 415     
Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser
            420                 425                 430         
Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His
        435                 440                 445             
Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg
    450                 455                 460                 
Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln
465                 470                 475                 480 
Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser
                485                 490                 495     
Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu
            500                 505                 510         
Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro
        515                 520                 525             
Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu
    530                 535                 540                 
Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val
545                 550                 555                 560 
Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile
                565                 570                 575     
Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr
            580                 585                 590         
Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly
        595                 600                 605             
Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu
    610                 615                 620                 
Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr
625                 630                 635                 640 
Gly Met Leu Ala Asp Ile Pro Val Thr Ile Cys Thr Tyr Pro Phe Val
                645                 650                 655     
Phe Asp Ala Gln Ala Lys Thr Thr Leu Leu Gln Thr Asp Ala Val Leu
            660                 665                 670         
Gln Met Gln Met Ala Ile Asp Gln Ala His Arg Gln Asn Val Ser Ser
        675                 680                 685             
Leu Phe Leu Pro Val Ile Glu Ser Val Asn Pro Cys Leu Ile Leu Val
    690                 695                 700                 
Val Arg Arg Glu Asn Ile Val Gly Asp Ala Met Glu Val Leu Arg Lys
705                 710                 715                 720 
Thr Lys Asn Ile Asp Tyr Lys Lys Pro Leu Lys Val Ile Phe Val Gly
                725                 730                 735     
Glu Asp Ala Val Asp Ala Gly Gly Val Arg Lys Glu Phe Phe Leu Leu
            740                 745                 750         
Ile Met Arg Glu Leu Leu Asp Pro Lys Tyr Gly Met Phe Arg Tyr Tyr
        755                 760                 765             
Glu Asp Ser Arg Leu Ile Trp Phe Ser Asp Lys Thr Phe Glu Asp Ser
    770                 775                 780                 
Asp Leu Phe His Leu Ile Gly Val Ile Cys Gly Leu Ala Ile Tyr Asn
785                 790                 795                 800 
Cys Thr Ile Val Asp Leu His Phe Pro Leu Ala Leu Tyr Lys Lys Leu
                805                 810                 815     
Leu Lys Lys Lys Pro Ser Leu Asp Asp Leu Lys Glu Leu Met Pro Asp
            820                 825                 830         
Val Gly Arg Ser Met Gln Gln Leu Leu Asp Tyr Pro Glu Asp Asp Ile
        835                 840                 845             
Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Thr Val Glu Asn Phe Gly
    850                 855                 860                 
Ala Thr Glu Val Lys Glu Leu Val Leu Asn Gly Ala Asp Thr Ala Val
865                 870                 875                 880 
Asn Lys Gln Asn Arg Gln Glu Phe Val Asp Ala Tyr Val Asp Tyr Ile
                885                 890                 895     
Phe Asn Lys Ser Val Ala Ser Leu Phe Asp Ala Phe His Ala Gly Phe
            900                 905                 910         
His Lys Val Cys Gly Gly Lys Val Leu Leu Leu Phe Gln Pro Asn Glu
        915                 920                 925             
Leu Gln Ala Met Val Ile Gly Asn Thr Asn Tyr Asp Trp Lys Glu Leu
    930                 935                 940                 
Glu Lys Asn Thr Glu Tyr Lys Gly Glu Tyr Trp Ala Glu His Pro Thr
945                 950                 955                 960 
Ile Lys Ile Phe Trp Glu Val Phe His Glu Leu Pro Leu Glu Lys Lys
                965                 970                 975     
Lys Gln Phe Leu Leu Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile Leu
            980                 985                 990         
Gly Met Lys Ser Leu Lys Leu Val Ile Gln Ser Thr Gly Gly Gly Glu
        995                 1000                1005            
Glu Tyr Leu Pro Val Ser His Thr Cys Phe Asn Leu Leu Asp Leu Pro
    1010                1015                1020                
Lys Tyr Thr Glu Lys Glu Thr Leu Arg Ser Lys Leu Ile Gln Ala Ile
1025                1030                1035                1040
Asp His Asn Glu Gly Phe Ser Leu Ile
                1045                


<210> 8379
<211> 953
<212> PRT
<213> Homo sapiens

<400> 8379
Ser Cys Phe Pro Lys Ile Met Cys Val Asp Ser Leu Val Arg Ile Cys
 1               5                  10                  15      
Ser Gly Leu Ser Tyr Gly Arg Ile Arg Asn Ile Lys Ser Leu Ser Asp
            20                  25                  30          
Ile Gln Ile Val Gln Val Ala Cys Gly Tyr Tyr His Ser Leu Ala Leu
        35                  40                  45              
Ser Lys Ala Ser Glu Val Phe Cys Trp Gly Gln Asn Lys Tyr Gly Gln
    50                  55                  60                  
Leu Gly Leu Gly Thr Asp Cys Lys Lys Gln Thr Ser Pro Gln Leu Leu
65                  70                  75                  80  
Lys Ser Leu Leu Gly Ile Pro Phe Met Gln Val Ala Ala Gly Gly Ala
                85                  90                  95      
His Ser Phe Val Leu Thr Leu Ser Gly Ala Ile Phe Gly Trp Gly Arg
            100                 105                 110         
Asn Lys Phe Gly Gln Leu Gly Leu Asn Asp Glu Asn Asp Arg Tyr Val
        115                 120                 125             
Pro Asn Leu Leu Lys Ser Leu Arg Ser Gln Lys Ile Val Tyr Ile Cys
    130                 135                 140                 
Cys Gly Glu Asp His Thr Ala Ala Leu Thr Lys Glu Gly Gly Val Phe
145                 150                 155                 160 
Thr Phe Gly Ala Gly Gly Tyr Gly Gln Leu Gly His Asn Ser Thr Ser
                165                 170                 175     
His Glu Ile Asn Pro Arg Lys Val Phe Glu Leu Met Gly Ser Ile Val
            180                 185                 190         
Thr Glu Ile Ala Cys Gly Arg Gln His Thr Ser Ala Phe Val Pro Ser
        195                 200                 205             
Ser Gly Arg Ile Tyr Ser Phe Gly Leu Gly Gly Asn Gly Gln Leu Gly
    210                 215                 220                 
Thr Gly Ser Thr Ser Asn Arg Lys Ser Pro Phe Thr Val Lys Gly Asn
225                 230                 235                 240 
Trp Tyr Pro Tyr Asn Gly Gln Cys Leu Pro Asp Ile Asp Ser Glu Glu
                245                 250                 255     
Tyr Phe Cys Val Lys Arg Ile Phe Ser Gly Gly Asp Gln Ser Phe Ser
            260                 265                 270         
His Tyr Ser Ser Pro Gln Asn Cys Gly Pro Pro Asp Asp Phe Arg Cys
        275                 280                 285             
Pro Asn Pro Thr Lys Gln Ile Trp Thr Val Asn Glu Ala Leu Ile Gln
    290                 295                 300                 
Lys Trp Leu Ser Tyr Pro Ser Gly Arg Phe Pro Val Glu Ile Ala Asn
305                 310                 315                 320 
Glu Ile Asp Gly Thr Phe Ser Ser Ser Gly Cys Leu Asn Gly Ser Phe
                325                 330                 335     
Leu Ala Val Ser Asn Asp Asp His Tyr Arg Thr Gly Thr Arg Phe Ser
            340                 345                 350         
Gly Val Asp Met Asn Ala Ala Arg Leu Leu Phe His Lys Leu Ile Gln
        355                 360                 365             
Pro Asp His Pro Gln Ile Ser Gln Gln Val Ala Ala Ser Leu Glu Lys
    370                 375                 380                 
Asn Leu Ile Pro Lys Leu Thr Ser Ser Leu Pro Asp Val Glu Ala Leu
385                 390                 395                 400 
Arg Phe Tyr Leu Thr Leu Pro Glu Cys Pro Leu Met Ser Asp Ser Asn
                405                 410                 415     
Asn Phe Thr Thr Ile Ala Ile Pro Phe Gly Thr Ala Leu Val Asn Leu
            420                 425                 430         
Glu Lys Ala Pro Leu Lys Val Leu Glu Asn Trp Trp Ser Val Leu Glu
        435                 440                 445             
Pro Pro Leu Phe Leu Lys Ile Val Glu Leu Phe Lys Glu Val Val Val
    450                 455                 460                 
His Leu Leu Lys Leu Tyr Lys Ile Gly Ile Pro Pro Ser Glu Arg Arg
465                 470                 475                 480 
Ile Phe Asn Ser Phe Leu His Thr Ala Leu Lys Val Leu Glu Ile Leu
                485                 490                 495     
His Arg Val Asn Glu Lys Met Gly Gln Ile Ile Gln Tyr Asp Lys Phe
            500                 505                 510         
Tyr Ile His Glu Val Gln Glu Leu Ile Asp Ile Arg Asn Asp Tyr Ile
        515                 520                 525             
Asn Trp Val Gln Gln Gln Ala Tyr Gly Met Asp Val Asn His Gly Leu
    530                 535                 540                 
Thr Glu Leu Ala Asp Ile Pro Val Thr Ile Cys Thr Tyr Pro Phe Val
545                 550                 555                 560 
Phe Asp Ala Gln Ala Lys Thr Thr Leu Leu Gln Thr Asp Ala Val Leu
                565                 570                 575     
Gln Met Gln Met Ala Ile Asp Gln Ala His Arg Gln Asn Val Ser Ser
            580                 585                 590         
Leu Phe Leu Pro Val Ile Glu Ser Val Asn Pro Cys Leu Ile Leu Val
        595                 600                 605             
Val Arg Arg Glu Asn Ile Val Gly Asp Ala Met Glu Val Leu Arg Lys
    610                 615                 620                 
Thr Lys Asn Ile Asp Tyr Lys Lys Pro Leu Lys Val Ile Phe Val Gly
625                 630                 635                 640 
Glu Asp Ala Val Asp Ala Gly Gly Val Arg Lys Glu Phe Phe Leu Leu
                645                 650                 655     
Ile Met Arg Glu Leu Leu Asp Pro Lys Tyr Gly Met Phe Arg Tyr Tyr
            660                 665                 670         
Glu Asp Ser Arg Leu Ile Trp Phe Ser Asp Lys Thr Phe Glu Asp Ser
        675                 680                 685             
Asp Leu Phe His Leu Ile Gly Val Ile Cys Gly Leu Ala Ile Tyr Asn
    690                 695                 700                 
Cys Thr Ile Val Asp Leu His Phe Pro Leu Ala Leu Tyr Lys Lys Leu
705                 710                 715                 720 
Leu Lys Lys Lys Pro Ser Leu Asp Asp Leu Lys Glu Leu Met Pro Asp
                725                 730                 735     
Val Gly Arg Ser Met Gln Gln Leu Leu Asp Tyr Pro Glu Asp Asp Ile
            740                 745                 750         
Glu Glu Thr Phe Cys Leu Asn Phe Thr Ile Thr Val Glu Asn Phe Gly
        755                 760                 765             
Ala Thr Glu Val Lys Glu Leu Val Leu Asn Gly Ala Asp Thr Ala Val
    770                 775                 780                 
Asn Lys Gln Asn Arg Gln Glu Phe Val Asp Ala Tyr Val Asp Tyr Ile
785                 790                 795                 800 
Phe Asn Lys Ser Val Ala Ser Leu Phe Asp Ala Phe His Ala Gly Phe
                805                 810                 815     
His Lys Val Cys Gly Gly Lys Val Leu Leu Leu Phe Gln Pro Asn Glu
            820                 825                 830         
Leu Gln Ala Met Val Ile Gly Asn Thr Asn Tyr Asp Trp Lys Glu Leu
        835                 840                 845             
Glu Lys Asn Thr Glu Tyr Lys Gly Glu Tyr Trp Ala Glu His Pro Thr
    850                 855                 860                 
Ile Lys Ile Phe Trp Glu Val Phe His Glu Leu Pro Leu Glu Lys Lys
865                 870                 875                 880 
Lys Gln Phe Leu Leu Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile Leu
                885                 890                 895     
Gly Met Lys Ser Leu Lys Leu Val Ile Gln Ser Thr Gly Gly Gly Glu
            900                 905                 910         
Glu Tyr Leu Pro Val Ser His Thr Cys Phe Asn Leu Leu Asp Leu Pro
        915                 920                 925             
Lys Tyr Thr Glu Lys Glu Thr Leu Arg Ser Lys Leu Ile Gln Ala Ile
    930                 935                 940                 
Asp His Asn Glu Gly Phe Ser Leu Ile
945                 950             


<210> 8380
<211> 331
<212> PRT
<213> Homo sapiens

<400> 8380
Met Glu Pro Glu Phe Leu Tyr Asp Leu Leu Gln Leu Pro Lys Gly Val
 1               5                  10                  15      
Glu Pro Pro Ala Glu Glu Glu Leu Ser Lys Gly Gly Lys Lys Lys Tyr
            20                  25                  30          
Leu Pro Pro Thr Ser Arg Lys Asp Pro Lys Phe Glu Glu Leu Gln Lys
        35                  40                  45              
Val Leu Met Glu Trp Ile Asn Ala Thr Leu Leu Pro Glu His Ile Val
    50                  55                  60                  
Val Arg Ser Leu Glu Glu Asp Met Phe Asp Gly Leu Ile Leu His His
65                  70                  75                  80  
Leu Phe Gln Arg Leu Ala Ala Leu Lys Leu Glu Ala Glu Asp Ile Ala
                85                  90                  95      
Leu Thr Ala Thr Ser Gln Lys His Lys Leu Thr Val Val Leu Glu Ala
            100                 105                 110         
Val Asn Arg Ser Leu Gln Leu Glu Glu Trp Gln Ala Lys Trp Ser Val
        115                 120                 125             
Glu Ser Ile Phe Asn Lys Asp Leu Leu Ser Thr Leu His Leu Leu Val
    130                 135                 140                 
Ala Leu Ala Lys Arg Phe Gln Pro Asp Leu Ser Leu Pro Thr Asn Val
145                 150                 155                 160 
Gln Val Glu Val Ile Thr Ile Glu Ser Thr Lys Ser Gly Leu Lys Ser
                165                 170                 175     
Glu Lys Leu Val Glu Gln Leu Thr Glu Tyr Ser Thr Asp Lys Asp Glu
            180                 185                 190         
Pro Pro Lys Asp Val Phe Asp Glu Leu Phe Lys Leu Ala Pro Glu Lys
        195                 200                 205             
Val Asn Ala Val Lys Glu Ala Ile Val Asn Phe Val Asn Gln Lys Leu
    210                 215                 220                 
Asp Arg Leu Gly Leu Ser Val Gln Asn Leu Asp Thr Gln Phe Ala Asp
225                 230                 235                 240 
Gly Val Ile Leu Leu Leu Leu Ile Gly Gln Leu Glu Gly Phe Phe Leu
                245                 250                 255     
His Leu Lys Glu Phe Tyr Leu Thr Pro Asn Ser Pro Ala Glu Met Leu
            260                 265                 270         
His Asn Val Thr Leu Ala Leu Glu Leu Leu Lys Asp Glu Gly Leu Leu
        275                 280                 285             
Ser Cys Pro Val Ser Pro Glu Asp Ile Val Asn Lys Asp Ala Lys Ser
    290                 295                 300                 
Thr Leu Arg Val Leu Tyr Gly Leu Phe Cys Lys His Thr Gln Lys Ala
305                 310                 315                 320 
His Arg Asp Arg Thr Pro His Gly Ala Pro Asn
                325                 330     


<210> 8381
<211> 706
<212> PRT
<213> Homo sapiens

<400> 8381
Met Lys Ile Phe Ser Glu Ser His Lys Thr Val Phe Val Val Asp His
 1               5                  10                  15      
Cys Pro Tyr Met Ala Glu Ser Cys Arg Gln His Val Glu Phe Asp Met
            20                  25                  30          
Leu Val Lys Asn Arg Thr Gln Gly Ile Ile Pro Leu Ala Pro Ile Ser
        35                  40                  45              
Lys Ser Leu Trp Thr Cys Ser Val Glu Ser Ser Met Glu Tyr Cys Arg
    50                  55                  60                  
Ile Met Tyr Asp Ile Phe Pro Phe Lys Lys Leu Val Asn Phe Ile Val
65                  70                  75                  80  
Ser Asp Ser Gly Ala His Val Leu Asn Ser Trp Thr Gln Glu Asp Gln
                85                  90                  95      
Asn Leu Gln Glu Leu Met Ala Ala Leu Ala Ala Val Gly Pro Pro Asn
            100                 105                 110         
Pro Arg Ala Asp Pro Glu Cys Cys Ser Ile Leu His Gly Leu Val Ala
        115                 120                 125             
Ala Val Glu Thr Leu Cys Lys Ile Thr Glu Tyr Gln His Glu Ala Arg
    130                 135                 140                 
Thr Leu Leu Met Glu Asn Ala Glu Arg Val Gly Asn Arg Gly Arg Ile
145                 150                 155                 160 
Ile Cys Ile Thr Asn Ala Lys Ser Asp Ser His Val Arg Met Leu Glu
                165                 170                 175     
Asp Cys Val Gln Glu Thr Ile His Glu His Asn Lys Leu Ala Ala Asn
            180                 185                 190         
Ser Asp His Leu Met Gln Ile Gln Lys Cys Glu Leu Val Leu Ile His
        195                 200                 205             
Thr Tyr Pro Val Gly Glu Asp Ser Leu Val Ser Asp Arg Ser Lys Lys
    210                 215                 220                 
Glu Leu Ser Pro Val Leu Thr Ser Glu Val His Ser Val Arg Ala Gly
225                 230                 235                 240 
Arg His Leu Ala Thr Lys Leu Asn Ile Leu Val Gln Gln His Phe Asp
                245                 250                 255     
Leu Ala Ser Thr Thr Ile Thr Asn Ile Pro Met Lys Glu Glu Gln His
            260                 265                 270         
Ala Asn Thr Ser Ala Asn Tyr Asp Val Glu Leu Leu His His Lys Asp
        275                 280                 285             
Ala His Val Asp Phe Leu Lys Ser Gly Asp Ser His Leu Gly Gly Gly
    290                 295                 300                 
Ser Arg Glu Gly Ser Phe Lys Glu Thr Ile Thr Leu Lys Trp Cys Thr
305                 310                 315                 320 
Pro Arg Thr Asn Asn Ile Glu Leu His Tyr Cys Thr Gly Ala Tyr Arg
                325                 330                 335     
Ile Ser Pro Val Asp Val Asn Ser Arg Pro Ser Ser Cys Leu Thr Asn
            340                 345                 350         
Phe Leu Leu Asn Gly Arg Ser Val Leu Leu Glu Gln Pro Arg Lys Ser
        355                 360                 365             
Gly Ser Lys Val Ile Ser His Met Leu Ser Ser His Gly Gly Glu Ile
    370                 375                 380                 
Phe Leu His Val Leu Ser Ser Ser Arg Ser Ile Leu Glu Asp Pro Pro
385                 390                 395                 400 
Ser Ile Ser Glu Gly Cys Gly Gly Arg Val Thr Asp Tyr Arg Ile Thr
                405                 410                 415     
Asp Phe Gly Glu Phe Met Arg Glu Asn Arg Leu Thr Pro Phe Leu Asp
            420                 425                 430         
Pro Arg Tyr Lys Ile Asp Gly Ser Leu Glu Val Pro Leu Glu Arg Ala
        435                 440                 445             
Lys Asp Gln Leu Glu Lys His Thr Arg Tyr Trp Pro Met Ile Ile Ser
    450                 455                 460                 
Gln Thr Thr Ile Phe Asn Met Gln Ala Val Val Pro Leu Ala Ser Val
465                 470                 475                 480 
Ile Val Lys Glu Ser Leu Thr Glu Glu Asp Val Leu Asn Cys Gln Lys
                485                 490                 495     
Thr Ile Tyr Asn Leu Val Asp Met Glu Arg Lys Asn Asp Pro Leu Pro
            500                 505                 510         
Ile Ser Thr Val Gly Thr Arg Gly Lys Gly Pro Lys Arg Asp Glu Gln
        515                 520                 525             
Tyr Arg Ile Met Trp Asn Glu Leu Glu Thr Leu Val Arg Ala His Ile
    530                 535                 540                 
Asn Asn Ser Glu Lys His Gln Arg Val Leu Glu Cys Leu Met Ala Cys
545                 550                 555                 560 
Arg Ser Lys Pro Pro Glu Glu Glu Glu Arg Lys Lys Arg Gly Arg Lys
                565                 570                 575     
Arg Glu Asp Lys Glu Asp Lys Ser Glu Lys Ala Val Lys Asp Tyr Glu
            580                 585                 590         
Gln Glu Lys Ser Trp Gln Asp Ser Glu Arg Leu Lys Gly Ile Leu Glu
        595                 600                 605             
Arg Gly Lys Glu Glu Leu Ala Glu Ala Glu Ile Ile Lys Asp Ser Pro
    610                 615                 620                 
Asp Ser Pro Glu Pro Pro Asn Lys Lys Pro Leu Val Glu Met Asp Glu
625                 630                 635                 640 
Thr Pro Gln Val Glu Lys Ser Lys Gly Pro Val Ser Leu Leu Ser Leu
                645                 650                 655     
Trp Ser Asn Arg Ile Asn Thr Ala Asn Ser Arg Lys His Gln Glu Phe
            660                 665                 670         
Ala Gly Arg Leu Asn Ser Val Asn Asn Arg Ala Glu Leu Tyr Gln His
        675                 680                 685             
Leu Lys Glu Glu Asn Gly Met Glu Thr Thr Glu Asn Gly Lys Ala Ser
    690                 695                 700                 
Arg Gln
705     


<210> 8382
<211> 203
<212> PRT
<213> Homo sapiens

<400> 8382
Met Ala Arg Pro Arg Pro Arg Glu Tyr Lys Ala Gly Asp Leu Val Phe
 1               5                  10                  15      
Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu Leu
            20                  25                  30          
Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr Pro Ile Phe Phe
        35                  40                  45              
Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro
    50                  55                  60                  
Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn Lys Arg Lys Gly
65                  70                  75                  80  
Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Gly Val Lys Phe
                85                  90                  95      
Thr Gly Tyr Gln Ala Ile Gln Gln Gln Ser Ser Ser Glu Thr Glu Gly
            100                 105                 110         
Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu Glu Gly Asp Arg
        115                 120                 125             
Val Glu Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu Lys Ala Gly Ser
    130                 135                 140                 
Lys Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser Lys Gln Ser Arg
145                 150                 155                 160 
Lys Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys Glu Glu Glu Asn
                165                 170                 175     
Lys Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn Asp Thr Arg Asn Thr
            180                 185                 190         
Thr Ser Asp Leu Gln Lys Thr Ser Glu Gly Thr
        195                 200             


<210> 8383
<211> 606
<212> PRT
<213> Homo sapiens

<400> 8383
Met Asp Ser Gln Arg Glu Leu Ala Glu Glu Leu Arg Leu Tyr Gln Ser
 1               5                  10                  15      
Thr Leu Leu Gln Asp Gly Leu Lys Asp Leu Leu Asp Glu Lys Lys Phe
            20                  25                  30          
Ile Asp Cys Thr Leu Lys Ala Gly Asp Lys Ser Leu Pro Cys His Arg
        35                  40                  45              
Leu Ile Leu Ser Ala Cys Ser Pro Tyr Phe Arg Glu Tyr Phe Leu Ser
    50                  55                  60                  
Glu Ile Asp Glu Ala Lys Lys Lys Glu Val Val Leu Asp Asn Val Asp
65                  70                  75                  80  
Pro Ala Ile Leu Asp Leu Ile Ile Lys Tyr Leu Tyr Ser Ala Ser Ile
                85                  90                  95      
Asp Leu Asn Asp Gly Asn Val Gln Asp Ile Phe Ala Leu Ala Ser Arg
            100                 105                 110         
Phe Gln Ile Pro Ser Val Phe Thr Val Cys Val Ser Tyr Leu Gln Lys
        115                 120                 125             
Arg Leu Ala Pro Gly Asn Cys Leu Ala Ile Leu Arg Leu Gly Leu Leu
    130                 135                 140                 
Leu Asp Cys Pro Arg Leu Ala Ile Ser Ala Arg Glu Phe Val Ser Asp
145                 150                 155                 160 
Arg Phe Val Gln Ile Cys Lys Glu Glu Asp Phe Met Gln Leu Ser Pro
                165                 170                 175     
Gln Glu Leu Ile Ser Val Ile Ser Asn Asp Ser Leu Asn Val Glu Lys
            180                 185                 190         
Glu Glu Ala Val Phe Glu Ala Val Met Lys Trp Val Arg Thr Asp Lys
        195                 200                 205             
Glu Asn Arg Val Lys Asn Leu Ser Glu Val Phe Asp Cys Ile Arg Phe
    210                 215                 220                 
Arg Leu Met Thr Glu Lys Tyr Phe Lys Asp His Val Glu Lys Asp Asp
225                 230                 235                 240 
Ile Ile Lys Ser Asn Pro Asp Leu Gln Lys Lys Ile Lys Val Leu Lys
                245                 250                 255     
Asp Ala Phe Ala Gly Lys Leu Pro Glu Pro Ser Lys Asn Ala Ala Lys
            260                 265                 270         
Thr Gly Ala Gly Glu Val Asn Gly Asp Val Gly Asp Glu Asp Leu Leu
        275                 280                 285             
Pro Gly Tyr Leu Asn Asp Ile Pro Arg His Gly Met Phe Val Lys Asp
    290                 295                 300                 
Leu Ile Leu Leu Val Asn Asp Thr Ala Ala Val Ala Tyr Asp Pro Thr
305                 310                 315                 320 
Glu Asn Glu Cys Tyr Leu Thr Ala Leu Ala Glu Gln Ile Pro Arg Asn
                325                 330                 335     
His Ser Ser Ile Val Thr Gln Gln Asn Gln Ile Tyr Val Val Gly Gly
            340                 345                 350         
Leu Tyr Val Asp Glu Glu Asn Lys Asp Gln Pro Leu Gln Ser Tyr Phe
        355                 360                 365             
Phe Gln Leu Asp Ser Ile Ala Ser Glu Trp Val Gly Leu Pro Pro Leu
    370                 375                 380                 
Pro Ser Ala Arg Cys Leu Phe Gly Leu Gly Glu Val Asp Asp Lys Ile
385                 390                 395                 400 
Tyr Val Val Ala Gly Lys Asp Leu Gln Thr Glu Ala Ser Leu Asp Ser
                405                 410                 415     
Val Leu Cys Tyr Asp Pro Val Ala Ala Lys Trp Asn Glu Val Lys Lys
            420                 425                 430         
Leu Pro Ile Lys Val Tyr Gly His Asn Val Ile Ser His Lys Gly Met
        435                 440                 445             
Ile Tyr Cys Leu Gly Gly Lys Thr Asp Asp Lys Lys Cys Thr Asn Arg
    450                 455                 460                 
Val Phe Ile Phe Asn Pro Lys Lys Gly Asp Trp Lys Asp Leu Ala Pro
465                 470                 475                 480 
Met Lys Ile Pro Arg Ser Met Phe Gly Val Ala Val His Lys Gly Lys
                485                 490                 495     
Ile Val Ile Ala Gly Gly Val Thr Glu Asp Gly Leu Ser Ala Ser Val
            500                 505                 510         
Glu Ala Phe Asp Leu Thr Thr Asn Lys Trp Asp Val Met Thr Glu Phe
        515                 520                 525             
Pro Gln Glu Arg Ser Ser Ile Ser Leu Val Ser Leu Ala Gly Ser Leu
    530                 535                 540                 
Tyr Ala Ile Gly Gly Phe Ala Met Ile Gln Leu Glu Ser Lys Glu Phe
545                 550                 555                 560 
Ala Pro Thr Glu Val Asn Asp Ile Trp Lys Tyr Glu Asp Asp Lys Lys
                565                 570                 575     
Glu Trp Ala Gly Met Leu Lys Glu Ile Arg Tyr Ala Ser Gly Ala Ser
            580                 585                 590         
Cys Leu Ala Thr Arg Leu Asn Leu Phe Lys Leu Ser Lys Leu
        595                 600                 605     


<210> 8384
<211> 596
<212> PRT
<213> Homo sapiens

<400> 8384
Met Arg Leu Tyr Gln Ser Thr Leu Leu Gln Asp Gly Leu Lys Asp Leu
 1               5                  10                  15      
Leu Asp Glu Lys Lys Phe Ile Asp Cys Thr Leu Lys Ala Gly Asp Lys
            20                  25                  30          
Ser Leu Pro Cys His Arg Leu Ile Leu Ser Ala Cys Ser Pro Tyr Phe
        35                  40                  45              
Arg Glu Tyr Phe Leu Ser Glu Ile Asp Glu Ala Lys Lys Lys Glu Val
    50                  55                  60                  
Val Leu Asp Asn Val Asp Pro Ala Ile Leu Asp Leu Ile Ile Lys Tyr
65                  70                  75                  80  
Leu Tyr Ser Ala Ser Ile Asp Leu Asn Asp Gly Asn Val Gln Asp Ile
                85                  90                  95      
Phe Ala Leu Ala Ser Arg Phe Gln Ile Pro Ser Val Phe Thr Val Cys
            100                 105                 110         
Val Ser Tyr Leu Gln Lys Arg Leu Ala Pro Gly Asn Cys Leu Ala Ile
        115                 120                 125             
Leu Arg Leu Gly Leu Leu Leu Asp Cys Pro Arg Leu Ala Ile Ser Ala
    130                 135                 140                 
Arg Glu Phe Val Ser Asp Arg Phe Val Gln Ile Cys Lys Glu Glu Asp
145                 150                 155                 160 
Phe Met Gln Leu Ser Pro Gln Glu Leu Ile Ser Val Ile Ser Asn Asp
                165                 170                 175     
Ser Leu Asn Val Glu Lys Glu Glu Ala Val Phe Glu Ala Val Met Lys
            180                 185                 190         
Trp Val Arg Thr Asp Lys Glu Asn Arg Val Lys Asn Leu Ser Glu Val
        195                 200                 205             
Phe Asp Cys Ile Arg Phe Arg Leu Met Thr Glu Lys Tyr Phe Lys Asp
    210                 215                 220                 
His Val Glu Lys Asp Asp Ile Ile Lys Ser Asn Pro Asp Leu Gln Lys
225                 230                 235                 240 
Lys Ile Lys Val Leu Lys Asp Ala Phe Ala Gly Lys Leu Pro Glu Pro
                245                 250                 255     
Ser Lys Asn Ala Ala Lys Thr Gly Ala Gly Glu Val Asn Gly Asp Val
            260                 265                 270         
Gly Asp Glu Asp Leu Leu Pro Gly Tyr Leu Asn Asp Ile Pro Arg His
        275                 280                 285             
Gly Met Phe Val Lys Asp Leu Ile Leu Leu Val Asn Asp Thr Ala Ala
    290                 295                 300                 
Val Ala Tyr Asp Pro Thr Glu Asn Glu Cys Tyr Leu Thr Ala Leu Ala
305                 310                 315                 320 
Glu Gln Ile Pro Arg Asn His Ser Ser Ile Val Thr Gln Gln Asn Gln
                325                 330                 335     
Ile Tyr Val Val Gly Gly Leu Tyr Val Asp Glu Glu Asn Lys Asp Gln
            340                 345                 350         
Pro Leu Gln Ser Tyr Phe Phe Gln Leu Asp Ser Ile Ala Ser Glu Trp
        355                 360                 365             
Val Gly Leu Pro Pro Leu Pro Ser Ala Arg Cys Leu Phe Gly Leu Gly
    370                 375                 380                 
Glu Val Asp Asp Lys Ile Tyr Val Val Ala Gly Lys Asp Leu Gln Thr
385                 390                 395                 400 
Glu Ala Ser Leu Asp Ser Val Leu Cys Tyr Asp Pro Val Ala Ala Lys
                405                 410                 415     
Trp Asn Glu Val Lys Lys Leu Pro Ile Lys Val Tyr Gly His Asn Val
            420                 425                 430         
Ile Ser His Lys Gly Met Ile Tyr Cys Leu Gly Gly Lys Thr Asp Asp
        435                 440                 445             
Lys Lys Cys Thr Asn Arg Val Phe Ile Phe Asn Pro Lys Lys Gly Asp
    450                 455                 460                 
Trp Lys Asp Leu Ala Pro Met Lys Ile Pro Arg Ser Met Phe Gly Val
465                 470                 475                 480 
Ala Val His Lys Gly Lys Ile Val Ile Ala Gly Gly Val Thr Glu Asp
                485                 490                 495     
Gly Leu Ser Ala Ser Val Glu Ala Phe Asp Leu Thr Thr Asn Lys Trp
            500                 505                 510         
Asp Val Met Thr Glu Phe Pro Gln Glu Arg Ser Ser Ile Ser Leu Val
        515                 520                 525             
Ser Leu Ala Gly Ser Leu Tyr Ala Ile Gly Gly Phe Ala Met Ile Gln
    530                 535                 540                 
Leu Glu Ser Lys Glu Phe Ala Pro Thr Glu Val Asn Asp Ile Trp Lys
545                 550                 555                 560 
Tyr Glu Asp Asp Lys Lys Glu Trp Ala Gly Met Leu Lys Glu Ile Arg
                565                 570                 575     
Tyr Ala Ser Gly Ala Ser Cys Leu Ala Thr Arg Leu Asn Leu Phe Lys
            580                 585                 590         
Leu Ser Lys Leu
        595     


<210> 8385
<211> 708
<212> PRT
<213> Homo sapiens

<400> 8385
Asp Trp Ile Leu Asp Gln Gly Arg Val Trp Glu Gln Ser Trp Gly Gln
 1               5                  10                  15      
Ser Gly Ser Pro Arg Ala Phe Lys Gly Trp Ala Arg Pro Trp Leu Ala
            20                  25                  30          
Gln Cys His Leu His Ala Asp Gln Gln Pro Arg Ala Met His Arg Met
        35                  40                  45              
Pro Asp Pro Gly Lys Phe Lys Leu Leu Glu Gln Ala Arg Asp Val Arg
    50                  55                  60                  
Glu Pro Val Arg Tyr Phe Ser Ser Val Glu Glu Val Ala Ser Val Phe
65                  70                  75                  80  
Pro Asp Arg Ile Phe Val Met Glu Ala Ile Thr Phe Ser Val Lys Val
                85                  90                  95      
Val Ser Gly Glu Phe Ser Glu Asp Ser Glu Val Tyr Asn Phe Thr Leu
            100                 105                 110         
His Ala Gly Asp Glu Leu Thr Leu Met Gly Gln Ala Glu Ile Leu Cys
        115                 120                 125             
Ala Lys Thr Thr Lys Glu Arg Ser Arg Phe Thr Thr Leu Leu Arg Lys
    130                 135                 140                 
Leu Gly Arg Ala Gly Ala Leu Ala Gly Val Gly Gly Gly Gly Pro Ala
145                 150                 155                 160 
Ser Ala Gly Ala Ala Gly Gly Thr Gly Gly Gly Gly Ala Arg Pro Val
                165                 170                 175     
Lys Gly Lys Met Pro Cys Leu Ile Cys Met Asn His Arg Thr Asn Glu
            180                 185                 190         
Ser Leu Ser Leu Pro Phe Gln Cys Gln Gly Arg Phe Ser Thr Arg Ser
        195                 200                 205             
Pro Leu Glu Leu Gln Met Gln Glu Gly Glu His Thr Val Arg Ala Ile
    210                 215                 220                 
Ile Glu Arg Val Arg Leu Pro Val Asn Val Leu Val Pro Ser Arg Pro
225                 230                 235                 240 
Pro Arg Asn Pro Tyr Asp Leu His Pro Val Arg Glu Gly His Cys Tyr
                245                 250                 255     
Lys Leu Val Ser Ile Ile Ser Lys Thr Val Val Leu Gly Leu Ala Leu
            260                 265                 270         
Arg Arg Glu Gly Pro Ala Pro Leu His Phe Leu Leu Leu Thr Asp Thr
        275                 280                 285             
Pro Arg Phe Ala Leu Pro Gln Gly Leu Leu Ala Gly Asp Pro Arg Val
    290                 295                 300                 
Glu Arg Leu Val Arg Asp Ser Ala Ser Tyr Cys Arg Glu Arg Phe Asp
305                 310                 315                 320 
Pro Asp Glu Tyr Ser Thr Ala Val Arg Glu Ala Pro Ala Glu Leu Ala
                325                 330                 335     
Glu Asp Cys Ala Ser Pro Arg Arg Ala Arg Leu Cys Leu Pro Ala Pro
            340                 345                 350         
Arg Ala Pro Gly Leu Ala Arg Ala Pro Gly Pro Leu Ala Pro Ala Pro
        355                 360                 365             
Ala Gly Glu Gly Asp Arg Glu Tyr Val Ser Pro Asp Trp Ala Ala Ala
    370                 375                 380                 
Pro Glu Pro Ala Ala Pro Pro Ala Glu Ile Pro Tyr Glu Glu Leu Trp
385                 390                 395                 400 
Ala His Gln Gly Pro Glu Gly Leu Val Arg Pro Pro Pro Gly Leu Asp
                405                 410                 415     
Leu Ile Ser Phe Gly Ala Ala Gly Pro Pro Arg Arg Glu Pro Glu Ala
            420                 425                 430         
Pro Pro Pro Pro Val Pro Pro Lys Ser Glu Ala Val Lys Glu Glu Cys
        435                 440                 445             
Arg Leu Leu Asn Ala Pro Pro Val Pro Pro Arg Gly Gly Asn Gly Ser
    450                 455                 460                 
Gly Arg Leu Ser Ser Ser Pro Pro Val Pro Pro Arg Phe Pro Lys Leu
465                 470                 475                 480 
Gln Pro Val His Ser Pro Ser Ser Ser Leu Ser Tyr Tyr Ser Ser Gly
                485                 490                 495     
Leu Gln Asp Gly Ala Gly Ser Arg Ser Gly Ser Gly Ser Pro Ser Pro
            500                 505                 510         
Asp Thr Tyr Ser Leu Tyr Cys Tyr Pro Cys Thr Trp Gly Asp Cys Lys
        515                 520                 525             
Glu Pro Val Leu Glu Pro Phe Asp Pro Phe Glu Leu Gly Gln Gly Ser
    530                 535                 540                 
Ser Pro Glu Pro Glu Leu Leu Arg Ser Gln Glu Pro Arg Ala Val Gly
545                 550                 555                 560 
Thr Pro Gly Pro Gly Pro Pro Leu Ser Pro Leu Gly Pro Ser Lys Ala
                565                 570                 575     
Phe Glu Pro Glu Gly Leu Val Leu His Gln Val Pro Thr Pro Leu Ser
            580                 585                 590         
Pro Ala Ala Leu Gln Gly Pro Glu Ala Gly Gly Ala Leu Phe Leu Thr
        595                 600                 605             
Gln Gly Arg Leu Glu Gly Pro Pro Ala Ser Pro Arg Asp Gly Ala Thr
    610                 615                 620                 
Gly Phe Gly Val Arg Asp Ala Ser Ser Trp Gln Pro Pro Ala Asp Leu
625                 630                 635                 640 
Ser Ala Leu Ser Leu Glu Glu Val Ser Arg Ser Leu Gly Phe Ile Gly
                645                 650                 655     
Leu Ser Glu Asp Val Val Ser Phe Phe Ala Arg Glu Arg Ile Asp Gly
            660                 665                 670         
Ser Ile Phe Val Gln Leu Ser Glu Asp Ile Leu Ala Asp Asp Phe His
        675                 680                 685             
Leu Thr Lys Leu Gln Val Lys Lys Ile Ile Gln Phe Ile Lys Gly Trp
    690                 695                 700                 
Arg Pro Lys Ile
705             


<210> 8386
<211> 342
<212> PRT
<213> Homo sapiens

<400> 8386
Lys Gly Pro Arg Gly Ser Gln Gly Gly Gly Gly Gly Gly Ser Ser Ser
 1               5                  10                  15      
Ser Ser Val Val Ser Ser Gly Gly Asp Glu Gly Tyr Gly Thr Gly Gly
            20                  25                  30          
Gly Gly Ser Ser Ala Thr Ser Gly Gly Arg Arg Gly Ser Leu Glu Met
        35                  40                  45              
Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp Ser Glu Asp Ser Ile
    50                  55                  60                  
Ser Ser Thr Ile Met Asp Val Asp Ser Thr Ile Ser Ser Gly Arg Ser
65                  70                  75                  80  
Thr Pro Ala Met Met Asn Gly Gln Gly Ser Thr Thr Ser Ser Ser Lys
                85                  90                  95      
Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe Asn
            100                 105                 110         
Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser Ile His Val Asp Gly
        115                 120                 125             
Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val Tyr
    130                 135                 140                 
Asn Thr Pro Ser Thr Ser Gln Ser Trp Leu Gln Arg His Met Leu Thr
145                 150                 155                 160 
His Ser Gly Asp Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn Ala
                165                 170                 175     
Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His Val Pro Thr His Phe
            180                 185                 190         
Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln Pro Lys Ala Lys Glu
        195                 200                 205             
Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg Arg Lys Leu Lys Asn
    210                 215                 220                 
Lys Arg Arg Arg Ser Leu Pro Arg Pro His Asp Phe Phe Asp Ala Gln
225                 230                 235                 240 
Thr Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser Ala
                245                 250                 255     
His Ile Glu Ser Leu Gly Lys Gly His Ser Val Val Phe His Ser Thr
            260                 265                 270         
Val Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu Leu
        275                 280                 285             
His Trp Met Pro Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu Ser
    290                 295                 300                 
Glu Arg His Gln Leu Lys Thr Lys Val Val His Leu Ser Lys Leu Pro
305                 310                 315                 320 
Lys Asp Thr Ala Leu Leu Leu Asp Pro Asn Ile Tyr Arg Thr Met Pro
                325                 330                 335     
Gln Lys Arg Leu Lys Arg
            340         


<210> 8387
<211> 84
<212> PRT
<213> Homo sapiens

<400> 8387
Leu Pro Ser Glu Asn Arg Tyr Arg Glu Val Ser Ser Ile Ser Ile Cys
 1               5                  10                  15      
Gly Asp Phe Gln Ala Gln Arg Met Lys Leu Arg Tyr Lys Glu Asp Gly
            20                  25                  30          
Lys Thr Leu Tyr Ala Asn Thr Ile Asn Gly Ser Gly Leu Ala Ile Asp
        35                  40                  45              
Arg Ile Ile Ala Ile Ile Leu Glu Gln Tyr Gln Thr Glu Ser Gly Tyr
    50                  55                  60                  
Ile Glu Ile Pro Glu Val Leu Ile Pro Tyr Phe Gly Lys Ile Lys Gln
65                  70                  75                  80  
Ile Thr Asn Lys
                


<210> 8388
<211> 588
<212> PRT
<213> Homo sapiens

<400> 8388
Met Gly Pro Leu Thr Phe Thr Asp Val Ala Ile Glu Phe Ser Leu Glu
 1               5                  10                  15      
Glu Trp Gln Cys Leu Asp Thr Ala Gln Gln Asn Leu Tyr Arg Asn Val
            20                  25                  30          
Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ala Val Ser
        35                  40                  45              
Lys Pro Asp Leu Ile Thr Cys Leu Glu Lys Glu Lys Glu Pro Cys Lys
    50                  55                  60                  
Met Lys Arg His Glu Met Val Asp Glu Pro Pro Val Val Cys Ser His
65                  70                  75                  80  
Phe Ala Glu Asp Phe Trp Pro Glu Gln Asp Ile Lys Asp Ser Phe Gln
                85                  90                  95      
Lys Val Thr Leu Arg Arg Tyr Asp Lys Arg Gly His Glu Asn Leu Gln
            100                 105                 110         
Leu Arg Lys Gly Tyr Lys Thr Val Gly Asp Cys Lys Leu Tyr Lys Gly
        115                 120                 125             
Gly Tyr Asn Gly Leu Asn Gln Cys Leu Thr Leu Thr Gln Ser Lys Met
    130                 135                 140                 
Tyr His Cys Asp Ile Tyr Val Lys Val Phe Tyr Ala Phe Ser Asn Ala
145                 150                 155                 160 
Asp Arg Tyr Lys Thr Arg Tyr Thr Gly Lys Lys Pro Phe Gln Cys Lys
                165                 170                 175     
Lys Cys Gly Lys Ser Phe Cys Met Leu Ser Gln Leu Thr Gln His Lys
            180                 185                 190         
Lys Ile His Ile Arg Glu Asn Thr Tyr Arg Cys Lys Glu Cys Cys Asn
        195                 200                 205             
Ala Phe Asn Gln Ser Ser Ala Leu Thr Asn His Lys Arg Ile Tyr Val
    210                 215                 220                 
Gly Glu Lys His Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Asn His
225                 230                 235                 240 
Tyr Ser Thr Leu Thr Asn His Lys Arg Ile His Ser Gly Glu Lys Pro
                245                 250                 255     
Tyr Lys Cys Asp Glu Cys Gly Lys Thr Phe Ser Ile Ser Ser Thr Phe
            260                 265                 270         
Thr Lys His Lys Ile Ile His Thr Glu Glu Lys Pro Tyr Lys Cys Lys
        275                 280                 285             
Glu Cys Gly Lys Ala Phe Asn Gln Phe Gln Leu Leu Leu Asn Tyr Lys
    290                 295                 300                 
Ile Ile His Thr Val Glu Lys Pro Tyr Lys Cys Glu Glu Cys Ala Lys
305                 310                 315                 320 
Pro Leu Ser Gly Pro Gln Pro Leu Thr Lys His Lys Ile Ile His Thr
                325                 330                 335     
Gly Glu Asn Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln
            340                 345                 350         
Ser Ser Arg Leu Thr Arg His Lys Lys Ile His Thr Gly Glu Glu Pro
        355                 360                 365             
Tyr Lys Phe Glu Lys Cys Gly Arg Val Phe Thr Cys Ser Ser Thr Leu
    370                 375                 380                 
Thr Gln Asp Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Asn Cys Glu
385                 390                 395                 400 
Glu Cys Gly Lys Val Phe Thr Tyr Ser Ser Thr Leu Thr Arg His Lys
                405                 410                 415     
Arg Ile His Thr Glu Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
            420                 425                 430         
Ala Phe Asn Arg Ser Ser His Leu Thr Ser His Arg Arg Ile His Thr
        435                 440                 445             
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln
    450                 455                 460                 
Ser Ser Asn Leu Asn Ser His Lys Lys Ile His Ser Gly Glu Lys Pro
465                 470                 475                 480 
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ile Leu Ser Ser Arg Leu
                485                 490                 495     
Thr Gln His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
            500                 505                 510         
Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Arg Leu Thr Gln His Lys
        515                 520                 525             
Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Asp Lys
    530                 535                 540                 
Ala Phe Thr His Ser Ser Asn Leu Ser Ser His Lys Lys Ile His Ser
545                 550                 555                 560 
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg
                565                 570                 575     
Ser Ser Arg Leu Thr Gln His Lys Lys Asn Ser Tyr
            580                 585             


<210> 8389
<211> 691
<212> PRT
<213> Homo sapiens

<400> 8389
Met Asn Ala Ala Val Val Arg Arg Thr Gln Glu Ala Leu Gly Lys Val
 1               5                  10                  15      
Ile Arg Arg Pro Pro Leu Thr Glu Lys Leu Leu Ser Lys Pro Pro Phe
            20                  25                  30          
Arg Tyr Leu His Asp Ile Ile Thr Glu Val Ile Arg Met Thr Gly Phe
        35                  40                  45              
Met Lys Gly Leu Tyr Thr Asp Ala Glu Met Lys Ser Asp Asn Val Lys
    50                  55                  60                  
Asp Lys Asp Ala Lys Ile Ser Phe Leu Gln Lys Ala Ile Asp Val Val
65                  70                  75                  80  
Val Met Val Ser Gly Glu Pro Leu Leu Ala Lys Pro Ala Arg Ile Val
                85                  90                  95      
Ala Gly His Glu Pro Glu Arg Thr Asn Glu Leu Leu Gln Ile Ile Gly
            100                 105                 110         
Lys Cys Cys Leu Asn Lys Leu Ser Ser Asp Asp Ala Val Arg Arg Val
        115                 120                 125             
Leu Ala Gly Glu Lys Gly Glu Val Lys Gly Arg Ala Ser Leu Thr Ser
    130                 135                 140                 
Arg Ser Gln Glu Leu Asp Asn Lys Asn Val Arg Glu Glu Glu Ser Arg
145                 150                 155                 160 
Val His Lys Asn Thr Glu Asp Arg Gly Asp Ala Glu Ile Lys Glu Arg
                165                 170                 175     
Ser Thr Ser Arg Asp Arg Lys Gln Lys Glu Glu Leu Lys Glu Asp Arg
            180                 185                 190         
Lys Pro Arg Glu Lys Asp Lys Asp Lys Glu Lys Ala Lys Glu Asn Gly
        195                 200                 205             
Gly Asn Arg His Arg Glu Gly Glu Arg Glu Arg Ala Lys Ala Arg Ala
    210                 215                 220                 
Arg Pro Asp Asn Glu Arg Gln Lys Asp Arg Gly Asn Arg Glu Arg Asp
225                 230                 235                 240 
Arg Asp Ser Glu Arg Lys Lys Glu Thr Glu Arg Lys Ser Glu Gly Gly
                245                 250                 255     
Lys Glu Lys Glu Arg Leu Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp
            260                 265                 270         
Lys Gly Lys Asp Arg Asp Arg Arg Arg Val Lys Asn Gly Glu His Ser
        275                 280                 285             
Trp Asp Leu Asp Arg Glu Lys Asn Arg Glu His Asp Lys Pro Glu Lys
    290                 295                 300                 
Lys Ser Ala Ser Ser Gly Glu Met Ser Lys Lys Leu Ser Asp Gly Thr
305                 310                 315                 320 
Phe Lys Asp Ser Lys Ala Glu Thr Glu Thr Glu Ile Ser Thr Arg Ala
                325                 330                 335     
Ser Lys Ser Leu Thr Thr Lys Thr Ser Lys Arg Arg Ser Lys Asn Ser
            340                 345                 350         
Val Glu Gly Arg Lys Glu Asp Asn Ile Ser Ala Lys Ser Leu Asp Ser
        355                 360                 365             
Ile Val Ser Gly Ile Asn Asn Glu Pro Asn Gln Glu Thr Thr Thr Ser
    370                 375                 380                 
Glu Ile Gly Thr Lys Glu Ala Asn Ile Asn Ser Thr Ser Ile Ser Asp
385                 390                 395                 400 
Asp Asn Ser Ala Ser Leu Arg Cys Glu Asn Ile Gln Pro Asn Pro Thr
                405                 410                 415     
Glu Lys Gln Lys Gly Asp Ser Thr Ser Asp Ala Glu Gly Asp Ala Gly
            420                 425                 430         
Pro Ala Gly Gln Asp Lys Ser Glu Val Pro Glu Thr Pro Glu Ile Pro
        435                 440                 445             
Asn Glu Leu Ser Ser Asn Ile Arg Arg Ile Pro Arg Pro Gly Ser Ala
    450                 455                 460                 
Arg Pro Ala Pro Pro Arg Val Lys Arg Gln Asp Ser Met Glu Ala Leu
465                 470                 475                 480 
Gln Met Asp Arg Ser Gly Ser Gly Lys Thr Val Ser Asn Val Ile Thr
                485                 490                 495     
Glu Ser His Asn Ser Asp Asn Glu Glu Asp Asp Gln Phe Val Val Glu
            500                 505                 510         
Ala Ala Pro Gln Leu Ser Glu Met Ser Glu Ile Glu Met Val Thr Ala
        515                 520                 525             
Val Glu Leu Glu Glu Glu Glu Lys His Gly Gly Leu Val Lys Lys Ile
    530                 535                 540                 
Leu Glu Thr Lys Lys Asp Tyr Glu Lys Leu Gln Gln Ser Pro Lys Pro
545                 550                 555                 560 
Gly Glu Lys Glu Arg Ser Leu Phe Glu Ser Ala Trp Lys Lys Glu Lys
                565                 570                 575     
Asp Ile Val Ser Lys Glu Ile Glu Lys Leu Arg Thr Ser Ile Gln Thr
            580                 585                 590         
Leu Cys Lys Ser Ala Leu Pro Leu Gly Lys Ile Met Asp Tyr Ile Gln
        595                 600                 605             
Glu Asp Val Asp Ala Met Gln Asn Glu Leu Gln Met Trp His Ser Glu
    610                 615                 620                 
Asn Arg Gln His Ala Glu Ala Leu Gln Gln Glu Gln Arg Ile Thr Asp
625                 630                 635                 640 
Cys Ala Val Glu Pro Leu Lys Ala Glu Leu Ala Glu Leu Glu Gln Leu
                645                 650                 655     
Ile Lys Asp Gln Gln Asp Lys Ile Cys Ala Val Lys Ala Asn Ile Leu
            660                 665                 670         
Lys Asn Glu Glu Lys Ile Gln Lys Met Val Tyr Ser Ile Asn Leu Thr
        675                 680                 685             
Ser Arg Arg
    690     


<210> 8390
<211> 323
<212> PRT
<213> Homo sapiens

<400> 8390
Met Ser Glu Arg Lys Val Leu Asn Lys Tyr Tyr Pro Pro Asp Phe Asp
 1               5                  10                  15      
Pro Ser Lys Ile Pro Lys Leu Lys Leu Pro Lys Asp Arg Gln Tyr Val
            20                  25                  30          
Val Arg Leu Met Ala Pro Phe Asn Met Arg Cys Lys Thr Cys Gly Glu
        35                  40                  45              
Tyr Ile Tyr Lys Gly Lys Lys Phe Asn Ala Arg Lys Glu Thr Val Gln
    50                  55                  60                  
Asn Glu Val Tyr Leu Gly Leu Pro Ile Phe Arg Phe Tyr Ile Lys Cys
65                  70                  75                  80  
Thr Arg Cys Leu Ala Glu Ile Thr Phe Lys Thr Asp Pro Glu Asn Thr
                85                  90                  95      
Asp Tyr Thr Met Glu His Gly Ala Thr Arg Asn Phe Gln Ala Glu Lys
            100                 105                 110         
Leu Leu Glu Glu Glu Glu Lys Arg Val Gln Lys Glu Arg Glu Asp Glu
        115                 120                 125             
Glu Leu Asn Asn Pro Met Lys Val Leu Glu Asn Arg Thr Lys Asp Ser
    130                 135                 140                 
Lys Leu Glu Met Glu Val Leu Glu Asn Leu Gln Glu Leu Lys Asp Leu
145                 150                 155                 160 
Asn Gln Arg Gln Ala His Val Asp Phe Glu Ala Met Leu Arg Gln His
                165                 170                 175     
Arg Leu Ser Glu Glu Glu Arg Arg Arg Gln Gln Gln Glu Glu Asp Glu
            180                 185                 190         
Gln Glu Thr Ala Ala Leu Leu Glu Glu Ala Arg Lys Arg Arg Leu Leu
        195                 200                 205             
Glu Asp Ser Asp Ser Glu Asp Glu Ala Ala Pro Ser Pro Leu Gln Pro
    210                 215                 220                 
Ala Leu Arg Pro Asn Pro Thr Ala Ile Leu Asp Glu Ala Pro Lys Pro
225                 230                 235                 240 
Lys Arg Lys Val Glu Val Trp Glu Gln Ser Val Gly Ser Leu Gly Ser
                245                 250                 255     
Arg Pro Pro Leu Ser Arg Leu Val Val Val Lys Lys Ala Lys Ala Asp
            260                 265                 270         
Pro Asp Cys Ser Asn Gly Gln Pro Gln Ala Ala Pro Thr Pro Gly Ala
        275                 280                 285             
Pro Gln Asn Arg Lys Glu Ala Asn Pro Thr Pro Leu Thr Pro Gly Ala
    290                 295                 300                 
Ser Ser Leu Ser Gln Leu Gly Ala Tyr Leu Asp Ser Asp Asp Ser Asn
305                 310                 315                 320 
Gly Ser Asn
            


<210> 8391
<211> 315
<212> PRT
<213> Homo sapiens

<400> 8391
Met Pro Gly Leu Ser Cys Arg Phe Tyr Gln His Lys Phe Pro Glu Val
 1               5                  10                  15      
Glu Asp Val Val Met Val Asn Val Arg Ser Ile Ala Glu Met Gly Ala
            20                  25                  30          
Tyr Val Ser Leu Leu Glu Tyr Asn Asn Ile Glu Gly Met Ile Leu Leu
        35                  40                  45              
Ser Glu Leu Ser Arg Arg Arg Ile Arg Ser Ile Asn Lys Leu Ile Arg
    50                  55                  60                  
Ile Gly Arg Asn Glu Cys Val Val Val Ile Arg Val Asp Lys Glu Lys
65                  70                  75                  80  
Gly Tyr Ile Asp Leu Ser Lys Arg Arg Val Ser Pro Glu Glu Ala Ile
                85                  90                  95      
Lys Cys Glu Asp Lys Phe Thr Lys Ser Lys Thr Val Tyr Ser Ile Leu
            100                 105                 110         
Arg His Val Ala Glu Val Leu Glu Tyr Thr Lys Asp Glu Gln Leu Glu
        115                 120                 125             
Ser Leu Phe Gln Arg Thr Ala Trp Val Phe Asp Asp Lys Tyr Lys Arg
    130                 135                 140                 
Pro Gly Tyr Gly Ala Tyr Asp Ala Phe Lys His Ala Val Ser Asp Pro
145                 150                 155                 160 
Ser Ile Leu Asp Ser Leu Asp Leu Asn Glu Asp Glu Arg Glu Val Leu
                165                 170                 175     
Ile Asn Asn Ile Asn Arg Arg Leu Thr Pro Gln Ala Val Lys Ile Arg
            180                 185                 190         
Ala Asp Ile Glu Val Ala Cys Tyr Gly Tyr Glu Gly Ile Asp Ala Val
        195                 200                 205             
Lys Glu Ala Leu Arg Ala Gly Leu Asn Cys Ser Thr Glu Asn Met Pro
    210                 215                 220                 
Ile Lys Ile Asn Leu Ile Ala Pro Pro Arg Tyr Val Met Thr Thr Thr
225                 230                 235                 240 
Thr Leu Glu Arg Thr Glu Gly Leu Ser Val Leu Ser Gln Ala Met Ala
                245                 250                 255     
Val Ile Lys Glu Lys Ile Glu Glu Lys Arg Gly Val Phe Asn Val Gln
            260                 265                 270         
Met Glu Pro Lys Val Val Thr Asp Thr Asp Glu Thr Glu Leu Ala Arg
        275                 280                 285             
Gln Met Glu Arg Leu Glu Arg Glu Asn Ala Glu Val Asp Gly Asp Asp
    290                 295                 300                 
Asp Ala Glu Glu Met Glu Ala Lys Ala Glu Asp
305                 310                 315 


<210> 8392
<211> 350
<212> PRT
<213> Homo sapiens

<400> 8392
Met Ala Ser Pro Pro Pro Phe His Ser Gln Lys Leu Pro Gly Glu Tyr
 1               5                  10                  15      
Phe Arg Tyr Lys Gly Val Pro Phe Pro Val Gly Leu Tyr Ser Leu Glu
            20                  25                  30          
Ser Ile Ser Leu Ala Glu Asn Thr Gln Asp Val Arg Asp Asp Asp Ile
        35                  40                  45              
Phe Ile Ile Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met Ile Glu Ile
    50                  55                  60                  
Ile Cys Leu Ile Leu Lys Glu Gly Asp Pro Ser Trp Ile Arg Ser Val
65                  70                  75                  80  
Pro Ile Trp Glu Arg Ala Pro Trp Cys Glu Thr Ile Val Gly Ala Phe
                85                  90                  95      
Ser Leu Pro Asp Gln Tyr Ser Pro Arg Leu Met Ser Ser His Leu Pro
            100                 105                 110         
Ile Gln Ile Phe Thr Lys Ala Phe Phe Ser Ser Lys Ala Lys Val Ile
        115                 120                 125             
Tyr Met Gly Arg Asn Pro Arg Asp Val Val Val Ser Leu Tyr His Tyr
    130                 135                 140                 
Ser Lys Ile Ala Gly Gln Leu Lys Asp Pro Gly Thr Pro Asp Gln Phe
145                 150                 155                 160 
Leu Arg Asp Phe Leu Lys Gly Glu Val Gln Phe Gly Ser Trp Phe Asp
                165                 170                 175     
His Ile Lys Gly Trp Leu Arg Met Lys Gly Lys Asp Asn Phe Leu Phe
            180                 185                 190         
Ile Thr Tyr Glu Glu Leu Gln Gln Asp Leu Gln Gly Ser Val Glu Arg
        195                 200                 205             
Ile Cys Gly Phe Leu Gly Arg Pro Leu Gly Lys Glu Ala Leu Gly Ser
    210                 215                 220                 
Val Val Ala His Ser Thr Phe Ser Ala Met Lys Ala Asn Thr Met Ser
225                 230                 235                 240 
Asn Tyr Thr Leu Leu Pro Pro Ser Leu Leu Asp His Arg Arg Gly Ala
                245                 250                 255     
Phe Leu Arg Lys Gly Val Cys Gly Asp Trp Lys Asn His Phe Thr Val
            260                 265                 270         
Ala Gln Ser Glu Ala Phe Asp Arg Ala Tyr Arg Lys Gln Met Arg Gly
        275                 280                 285             
Met Pro Thr Phe Pro Trp Asp Glu Asp Pro Glu Glu Asp Gly Ser Pro
    290                 295                 300                 
Asp Pro Glu Pro Ser Pro Glu Pro Glu Pro Lys Pro Ser Leu Glu Pro
305                 310                 315                 320 
Asn Thr Ser Leu Glu Arg Glu Pro Arg Pro Asn Ser Ser Pro Ser Pro
                325                 330                 335     
Ser Pro Gly Gln Ala Ser Glu Thr Pro His Pro Arg Pro Ser
            340                 345                 350 


<210> 8393
<211> 365
<212> PRT
<213> Homo sapiens

<400> 8393
Met Asp Gly Pro Ala Glu Pro Gln Ile Pro Gly Leu Trp Asp Thr Tyr
 1               5                  10                  15      
Glu Asp Asp Ile Ser Glu Ile Ser Gln Lys Leu Pro Gly Glu Tyr Phe
            20                  25                  30          
Arg Tyr Lys Gly Val Pro Phe Pro Val Gly Leu Tyr Ser Leu Glu Ser
        35                  40                  45              
Ile Ser Leu Ala Glu Asn Thr Gln Asp Val Arg Asp Asp Asp Ile Phe
    50                  55                  60                  
Ile Ile Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met Ile Glu Ile Ile
65                  70                  75                  80  
Cys Leu Ile Leu Lys Glu Gly Asp Pro Ser Trp Ile Arg Ser Val Pro
                85                  90                  95      
Ile Trp Glu Arg Ala Pro Trp Cys Glu Thr Ile Val Gly Ala Phe Ser
            100                 105                 110         
Leu Pro Asp Gln Tyr Ser Pro Arg Leu Met Ser Ser His Leu Pro Ile
        115                 120                 125             
Gln Ile Phe Thr Lys Ala Phe Phe Ser Ser Lys Ala Lys Val Ile Tyr
    130                 135                 140                 
Met Gly Arg Asn Pro Arg Asp Val Val Val Ser Leu Tyr His Tyr Ser
145                 150                 155                 160 
Lys Ile Ala Gly Gln Leu Lys Asp Pro Gly Thr Pro Asp Gln Phe Leu
                165                 170                 175     
Arg Asp Phe Leu Lys Gly Glu Val Gln Phe Gly Ser Trp Phe Asp His
            180                 185                 190         
Ile Lys Gly Trp Leu Arg Met Lys Gly Lys Asp Asn Phe Leu Phe Ile
        195                 200                 205             
Thr Tyr Glu Glu Leu Gln Gln Asp Leu Gln Gly Ser Val Glu Arg Ile
    210                 215                 220                 
Cys Gly Phe Leu Gly Arg Pro Leu Gly Lys Glu Ala Leu Gly Ser Val
225                 230                 235                 240 
Val Ala His Ser Thr Phe Ser Ala Met Lys Ala Asn Thr Met Ser Asn
                245                 250                 255     
Tyr Thr Leu Leu Pro Pro Ser Leu Leu Asp His Arg Arg Gly Ala Phe
            260                 265                 270         
Leu Arg Lys Gly Val Cys Gly Asp Trp Lys Asn His Phe Thr Val Ala
        275                 280                 285             
Gln Ser Glu Ala Phe Asp Arg Ala Tyr Arg Lys Gln Met Arg Gly Met
    290                 295                 300                 
Pro Thr Phe Pro Trp Asp Glu Asp Pro Glu Glu Asp Gly Ser Pro Asp
305                 310                 315                 320 
Pro Glu Pro Ser Pro Glu Pro Glu Pro Lys Pro Ser Leu Glu Pro Asn
                325                 330                 335     
Thr Ser Leu Glu Arg Glu Pro Arg Pro Asn Ser Ser Pro Ser Pro Ser
            340                 345                 350         
Pro Gly Gln Ala Ser Glu Thr Pro His Pro Arg Pro Ser
        355                 360                 365 


<210> 8394
<211> 503
<212> PRT
<213> Homo sapiens

<400> 8394
Met Glu Asn Asn Met Val Glu Leu Ser Lys Leu Gln Glu Tyr Lys Leu
 1               5                  10                  15      
Glu Leu Asp Glu Arg Ala Met Gln Ala Val Glu Lys Leu Glu Glu Ile
            20                  25                  30          
His Leu Gln Lys Gln Ala Gln Tyr Glu Lys Gln Leu Glu Gln Leu Asn
        35                  40                  45              
Lys Asp Asn Thr Ala Ser Leu Asn Met Lys Glu Leu Thr Leu Lys Asp
    50                  55                  60                  
Val Glu Cys Lys Phe Ser Lys Met Lys Thr Thr Tyr Glu Glu Val Thr
65                  70                  75                  80  
Thr Lys Leu Glu Glu Tyr Lys Glu Ala Phe Ala Ala Ala Leu Asn Ala
                85                  90                  95      
Asn Asn Ser Met Ser Lys Lys Leu Thr Lys Ser Asn Lys Lys Ile Ala
            100                 105                 110         
Met Ile Ser Thr Lys Leu Leu Met Glu Lys Glu Trp Val Lys Tyr Phe
        115                 120                 125             
Leu Ser Thr Leu Pro Thr Arg Arg Gly Gln Glu Ser Pro Cys Val Glu
    130                 135                 140                 
Asn Leu Thr Ser Ile Val Leu Asn Ser Lys Tyr Ile Pro Lys Met Thr
145                 150                 155                 160 
Val Arg Ile Pro Thr Ser Asn Pro Gln Thr Ser Asn Asn Cys Gln Asn
                165                 170                 175     
Tyr Leu Thr Glu Phe Cys His Pro His Gly Thr Val Ser Gln His Thr
            180                 185                 190         
Glu Thr Ile Leu Arg Lys His Arg His His Gln Val Leu Arg Val Leu
        195                 200                 205             
Val Glu Ile Glu Gly Ile Asn Leu Cys Tyr Leu Leu His Gln Lys Ala
    210                 215                 220                 
His Asp Ile Asp Ile Lys Val Glu Glu Gln Leu Pro His Pro Leu Arg
225                 230                 235                 240 
Tyr Gln Glu Thr Ser Lys Gly Pro Ser Gly Cys Leu Gly Thr Val Leu
                245                 250                 255     
Met Trp Ser Leu Ala Gln Pro Gln Arg Phe Trp Ile Ser Leu Pro Val
            260                 265                 270         
Ala Ser Val Leu Ser Leu Asp Arg Gly Ser Val Gly Arg Ala Leu Gly
        275                 280                 285             
Asp Pro Thr Ala Gln Gly Val Ser Ser Ala Lys Cys Pro Ser Leu Pro
    290                 295                 300                 
Asn Thr Leu Thr Leu Arg Asn Arg Val Asp Gly Val Ser Arg Gln Cys
305                 310                 315                 320 
Gln Ala Thr Ser Leu Ser Pro Leu Arg Trp Ala Gln Arg Ala Phe Arg
                325                 330                 335     
Gly Phe Tyr Ser Thr Val Gly Phe Leu Asp Ala Lys Arg Gln Thr Thr
            340                 345                 350         
Gly His Leu Glu Lys Asp Ser Val Gln Lys Gly Pro Asn Leu Val Asp
        355                 360                 365             
Glu Pro His Gly Gln Leu Leu Asp Ala Gly Thr Val Pro His Phe Leu
    370                 375                 380                 
Ser Leu Leu Met Arg Pro Thr Ser Thr Glu Glu Thr Ala Trp Arg Gln
385                 390                 395                 400 
Gly Lys Arg Lys Ala Glu Lys Asp Glu Leu Ala Leu Glu Leu Asp Gln
                405                 410                 415     
Ala Ile His Phe Ser Ile Glu Ile Phe His Thr Val Ser Glu Val Phe
            420                 425                 430         
Ala Asn Gln Ser Arg Gln Asp Leu Asp Pro Ala Met Asp Leu Leu Val
        435                 440                 445             
Leu Ser Gln Gly His Gln Thr Asn Ile Leu Asp Ile Ile His Ile His
    450                 455                 460                 
Lys Glu Ala Leu Thr Lys Val Thr Glu Ser Arg Gln Gln Val Ala Glu
465                 470                 475                 480 
Gly Lys Ile Asp Val Gln Arg Leu Met Met Ser Glu Ser Gln Glu Gln
                485                 490                 495     
Asp Phe Phe Gly His Phe Gly
            500             


<210> 8395
<211> 207
<212> PRT
<213> Homo sapiens

<400> 8395
Met Lys Thr Thr Tyr Glu Glu Val Thr Thr Lys Leu Glu Glu Tyr Lys
 1               5                  10                  15      
Glu Ala Phe Ala Ala Ala Leu Asn Ala Asn Asn Ser Met Ser Lys Lys
            20                  25                  30          
Leu Thr Lys Ser Asn Lys Lys Ile Ala Met Ile Ser Thr Lys Leu Leu
        35                  40                  45              
Met Glu Lys Glu Trp Val Lys Tyr Phe Leu Ser Thr Leu Pro Thr Arg
    50                  55                  60                  
Arg Gly Gln Glu Ser Pro Cys Val Glu Asn Leu Thr Ser Ile Val Leu
65                  70                  75                  80  
Asn Ser Lys Tyr Ile Pro Lys Met Thr Val Arg Ile Pro Thr Ser Asn
                85                  90                  95      
Pro Gln Thr Ser Asn Asn Cys Gln Asn Tyr Leu Thr Glu Met Glu Leu
            100                 105                 110         
Asp Cys Val Glu Gln Ile Ile Arg Glu Thr Lys Arg Thr Val Ala Val
        115                 120                 125             
Leu Asp Thr Cys Ser His Leu Phe Ser Ser Leu Glu Ser Thr Glu Val
    130                 135                 140                 
Glu Pro Leu Arg Lys His Arg Arg Ala Leu Pro Ser Val Tyr Ser Leu
145                 150                 155                 160 
Val Pro Asn Arg Arg Thr Ala Ala Ala Ser Thr Glu Ser Arg Thr Lys
                165                 170                 175     
Arg Pro Gly Gly Val Arg Ser Pro Gly Leu Gln Leu Glu Gly Thr Ser
            180                 185                 190         
Thr Leu Gln Trp Glu Gln Gly Pro Ile Ala His Pro Arg Gln Arg
        195                 200                 205         


<210> 8396
<211> 1297
<212> PRT
<213> Homo sapiens

<400> 8396
Val Asp Val Ile Thr Pro Leu Lys Asp Val Asn Val Ile Glu Gly Thr
 1               5                  10                  15      
Lys Ala Val Leu Glu Cys Lys Val Ser Val Pro Asp Val Thr Ser Val
            20                  25                  30          
Lys Trp Tyr Leu Asn Asp Glu Gln Ile Lys Pro Asp Asp Arg Val Gln
        35                  40                  45              
Ala Ile Val Lys Gly Thr Lys Gln Arg Leu Val Ile Asn Arg Thr His
    50                  55                  60                  
Ala Ser Asp Glu Gly Pro Tyr Lys Leu Ile Val Gly Arg Val Glu Thr
65                  70                  75                  80  
Asn Cys Asn Leu Ser Val Glu Lys Ile Lys Ile Ile Arg Gly Leu Arg
                85                  90                  95      
Asp Leu Thr Cys Thr Glu Thr Gln Asn Val Val Phe Glu Val Glu Leu
            100                 105                 110         
Ser His Ser Gly Ile Asp Val Leu Trp Asn Phe Lys Asp Lys Glu Ile
        115                 120                 125             
Lys Pro Ser Ser Lys Tyr Lys Ile Glu Ala His Gly Lys Ile Tyr Lys
    130                 135                 140                 
Leu Thr Val Leu Asn Met Met Lys Asp Asp Glu Gly Lys Tyr Thr Phe
145                 150                 155                 160 
Tyr Ala Gly Glu Asn Met Thr Ser Gly Lys Leu Thr Val Ala Gly Gly
                165                 170                 175     
Ala Ile Ser Lys Pro Leu Thr Asp Gln Thr Val Ala Glu Ser Gln Glu
            180                 185                 190         
Ala Val Phe Glu Cys Glu Val Ala Asn Pro Asp Ser Lys Gly Glu Trp
        195                 200                 205             
Leu Arg Asp Gly Lys His Leu Pro Leu Thr Asn Asn Ile Arg Ser Glu
    210                 215                 220                 
Ser Asp Gly His Lys Arg Arg Leu Ile Ile Ala Ala Thr Lys Leu Asp
225                 230                 235                 240 
Asp Ile Gly Glu Tyr Thr Tyr Lys Val Ala Thr Ser Lys Thr Ser Ala
                245                 250                 255     
Lys Leu Lys Val Glu Gly Lys Val Thr Val Lys Ile Lys Lys Thr Leu
            260                 265                 270         
Lys Asn Leu Thr Val Thr Glu Thr Gln Asp Ala Val Phe Thr Val Glu
        275                 280                 285             
Leu Thr His Pro Asn Val Lys Gly Val Gln Trp Ile Lys Asn Gly Val
    290                 295                 300                 
Val Leu Glu Ser Asn Glu Lys Tyr Ala Ile Ser Val Lys Gly Thr Ile
305                 310                 315                 320 
Tyr Ser Leu Arg Ile Lys Asn Cys Ala Ile Val Asp Glu Ser Val Tyr
                325                 330                 335     
Gly Phe Arg Leu Gly Arg Leu Gly Ala Ser Ala Arg Leu His Val Glu
            340                 345                 350         
Thr Val Lys Ile Ile Lys Lys Pro Lys Asp Val Thr Ala Leu Glu Asn
        355                 360                 365             
Ala Thr Val Ala Phe Glu Val Ser Val Ser His Asp Thr Val Pro Val
    370                 375                 380                 
Lys Trp Phe His Lys Ser Val Glu Ile Lys Pro Ser Asp Lys His Arg
385                 390                 395                 400 
Leu Val Ser Glu Arg Lys Val His Lys Leu Met Leu Gln Asn Ile Ser
                405                 410                 415     
Pro Ser Asp Ala Gly Glu Tyr Thr Ala Val Val Gly Gln Leu Glu Cys
            420                 425                 430         
Lys Ala Lys Leu Phe Val Glu Thr Leu His Ile Thr Lys Thr Met Lys
        435                 440                 445             
Asn Ile Glu Val Pro Glu Thr Lys Thr Ala Ser Phe Glu Cys Glu Val
    450                 455                 460                 
Ser His Phe Asn Val Pro Ser Met Trp Leu Lys Asn Gly Val Glu Ile
465                 470                 475                 480 
Glu Met Ser Glu Lys Phe Lys Ile Val Val Gln Gly Lys Leu His Gln
                485                 490                 495     
Leu Ile Ile Met Asn Thr Ser Thr Glu Asp Ser Ala Glu Tyr Thr Phe
            500                 505                 510         
Val Cys Gly Asn Asp Gln Val Ser Ala Thr Leu Thr Val Thr Pro Ile
        515                 520                 525             
Met Ile Thr Ser Met Leu Lys Asp Ile Asn Ala Glu Glu Lys Asp Thr
    530                 535                 540                 
Ile Thr Phe Glu Val Thr Val Asn Tyr Glu Gly Ile Ser Tyr Lys Trp
545                 550                 555                 560 
Leu Lys Asn Gly Val Glu Ile Lys Ser Thr Asp Lys Cys Gln Met Arg
                565                 570                 575     
Thr Lys Lys Leu Thr His Ser Leu Asn Ile Arg Asn Val His Phe Gly
            580                 585                 590         
Asp Ala Ala Asp Tyr Thr Phe Val Ala Gly Lys Ala Thr Ser Thr Ala
        595                 600                 605             
Thr Leu Tyr Val Glu Ala Arg His Ile Glu Phe Arg Lys His Ile Lys
    610                 615                 620                 
Asp Ile Lys Val Leu Glu Lys Lys Arg Ala Met Phe Glu Cys Glu Val
625                 630                 635                 640 
Ser Glu Pro Asp Ile Thr Val Gln Trp Met Lys Asp Asp Gln Glu Leu
                645                 650                 655     
Gln Ile Thr Asp Arg Ile Lys Ile Gln Lys Glu Lys Tyr Val His Arg
            660                 665                 670         
Leu Leu Ile Pro Ser Thr Arg Met Ser Asp Ala Gly Lys Tyr Thr Val
        675                 680                 685             
Val Ala Gly Gly Asn Val Ser Thr Ala Lys Leu Phe Val Glu Gly Arg
    690                 695                 700                 
Asp Val Arg Ile Arg Ser Ile Lys Lys Glu Val Gln Val Ile Glu Lys
705                 710                 715                 720 
Gln Arg Ala Val Val Glu Phe Glu Val Asn Glu Asp Asp Val Asp Ala
                725                 730                 735     
His Trp Tyr Lys Asp Gly Ile Glu Ile Asn Phe Gln Val Gln Glu Arg
            740                 745                 750         
His Lys Tyr Val Val Glu Arg Arg Ile His Arg Met Phe Ile Ser Glu
        755                 760                 765             
Thr Arg Gln Ser Asp Ala Gly Glu Tyr Thr Phe Val Ala Gly Arg Asn
    770                 775                 780                 
Arg Ser Ser Val Thr Leu Tyr Val Asn Ala Pro Glu Pro Pro Gln Val
785                 790                 795                 800 
Leu Gln Glu Leu Gln Pro Val Thr Val Gln Ser Gly Lys Pro Ala Arg
                805                 810                 815     
Phe Cys Ala Val Ile Ser Gly Arg Pro Gln Pro Lys Ile Ser Trp Tyr
            820                 825                 830         
Lys Glu Glu Gln Leu Leu Ser Thr Gly Phe Lys Cys Lys Phe Leu His
        835                 840                 845             
Asp Gly Gln Glu Tyr Thr Leu Leu Leu Ile Glu Ala Phe Pro Glu Asp
    850                 855                 860                 
Ala Ala Val Tyr Thr Cys Glu Ala Lys Asn Asp Tyr Gly Val Ala Thr
865                 870                 875                 880 
Thr Ser Ala Ser Leu Ser Val Glu Val Pro Glu Val Val Ser Pro Asp
                885                 890                 895     
Gln Glu Met Pro Val Tyr Pro Pro Ala Ile Ile Thr Pro Leu Gln Asp
            900                 905                 910         
Thr Val Thr Ser Glu Gly Gln Pro Ala Arg Phe Gln Cys Arg Val Ser
        915                 920                 925             
Gly Thr Asp Leu Lys Val Ser Trp Tyr Ser Lys Asp Lys Lys Ile Lys
    930                 935                 940                 
Pro Ser Arg Phe Phe Arg Met Thr Gln Phe Glu Asp Thr Tyr Gln Leu
945                 950                 955                 960 
Glu Ile Ala Glu Ala Tyr Pro Glu Asp Glu Gly Thr Tyr Thr Phe Val
                965                 970                 975     
Ala Ser Asn Ala Val Gly Gln Val Ser Ser Thr Ala Asn Leu Ser Leu
            980                 985                 990         
Glu Val Gln Ala Leu Asp Arg Gln Ser Ser Gly Lys Asp Val Arg Glu
        995                 1000                1005            
Ser Ala Lys Ser Gln Ala Val Ala Asp Ser Ser Phe Thr Lys Glu Glu
    1010                1015                1020                
Ser Lys Ile Ser Gln Lys Glu Ile Lys Ser Phe Gln Gly Ser Ser Tyr
1025                1030                1035                1040
Glu Tyr Glu Val Gln Val Phe Glu Ser Val Ser Gln Ser Ser Ile His
                1045                1050                1055    
Thr Ala Ala Ser Val Gln Asp Thr Gln Leu Cys His Thr Ala Ser Leu
            1060                1065                1070        
Ser Gln Ile Ala Glu Ser Thr Glu Leu Ser Lys Glu Cys Ala Lys Glu
        1075                1080                1085            
Ser Thr Gly Glu Ala Pro Lys Ile Phe Leu His Leu Gln Asp Val Thr
    1090                1095                1100                
Val Lys Cys Gly Asp Thr Ala Gln Phe Leu Cys Val Leu Lys Asp Asp
1105                1110                1115                1120
Ser Phe Ile Asp Val Thr Trp Thr His Glu Gly Ala Lys Ile Glu Glu
                1125                1130                1135    
Ser Glu Arg Leu Lys Gln Ser Gln Asn Gly Asn Ile Gln Phe Leu Thr
            1140                1145                1150        
Ile Cys Asn Val Gln Leu Val Asp Gln Gly Leu Tyr Ser Cys Ile Val
        1155                1160                1165            
His Asn Asp Cys Gly Glu Arg Thr Thr Ser Ala Val Leu Ser Val Glu
    1170                1175                1180                
Gly Ala Pro Glu Ser Ile Leu His Glu Arg Ile Glu Gln Glu Ile Glu
1185                1190                1195                1200
Met Glu Met Lys Ala Ala Pro Val Ile Lys Arg Lys Ile Glu Pro Leu
                1205                1210                1215    
Glu Val Ala Leu Gly His Leu Ala Lys Phe Thr Cys Glu Ile Gln Ser
            1220                1225                1230        
Ala Pro Asn Val Arg Phe Gln Trp Phe Lys Ala Gly Arg Glu Ile Tyr
        1235                1240                1245            
Glu Ser Asp Lys Cys Ser Ile Arg Ser Ser Lys Tyr Ile Ser Ser Leu
    1250                1255                1260                
Glu Ile Leu Arg Thr Gln Val Val Asp Cys Gly Glu Tyr Thr Cys Lys
1265                1270                1275                1280
Ala Ser Asn Glu Tyr Gly Ser Val Ser Cys Thr Ala Thr Leu Thr Val
                1285                1290                1295    
Thr
    


<210> 8397
<211> 1204
<212> PRT
<213> Homo sapiens

<400> 8397
Met Ser Phe Phe Asn Phe Arg Lys Ile Phe Lys Leu Gly Ser Glu Lys
 1               5                  10                  15      
Lys Lys Lys Gln Tyr Glu His Val Lys Arg Asp Leu Asn Pro Glu Asp
            20                  25                  30          
Phe Trp Glu Ile Ile Gly Glu Leu Gly Asp Gly Ala Phe Gly Lys Val
        35                  40                  45              
Tyr Lys Ala Gln Asn Lys Glu Thr Ser Val Leu Ala Ala Ala Lys Val
    50                  55                  60                  
Ile Asp Thr Lys Ser Glu Glu Glu Leu Glu Asp Tyr Met Val Glu Ile
65                  70                  75                  80  
Asp Ile Leu Ala Ser Cys Asp His Pro Asn Ile Val Lys Leu Leu Asp
                85                  90                  95      
Ala Phe Tyr Tyr Glu Asn Asn Leu Trp Ile Leu Ile Glu Phe Cys Ala
            100                 105                 110         
Gly Gly Ala Val Asp Ala Val Met Leu Glu Leu Glu Arg Pro Leu Thr
        115                 120                 125             
Glu Ser Gln Ile Gln Val Val Cys Lys Gln Thr Leu Asp Ala Leu Asn
    130                 135                 140                 
Tyr Leu His Asp Asn Lys Ile Ile His Arg Asp Leu Lys Ala Gly Asn
145                 150                 155                 160 
Ile Leu Phe Thr Leu Asp Gly Asp Ile Lys Leu Ala Asp Phe Gly Val
                165                 170                 175     
Ser Ala Lys Asn Thr Arg Thr Ile Gln Arg Arg Asp Ser Phe Ile Gly
            180                 185                 190         
Thr Pro Tyr Trp Met Ala Pro Glu Val Val Met Cys Glu Thr Ser Lys
        195                 200                 205             
Asp Arg Pro Tyr Asp Tyr Lys Ala Asp Val Trp Ser Leu Gly Ile Thr
    210                 215                 220                 
Leu Ile Glu Met Ala Glu Ile Glu Pro Pro His His Glu Leu Asn Pro
225                 230                 235                 240 
Met Arg Val Leu Leu Lys Ile Ala Lys Ser Glu Pro Pro Thr Leu Ala
                245                 250                 255     
Gln Pro Ser Arg Trp Ser Ser Asn Phe Lys Asp Phe Leu Lys Lys Cys
            260                 265                 270         
Leu Glu Lys Asn Val Asp Ala Arg Trp Thr Thr Ser Gln Leu Leu Gln
        275                 280                 285             
His Pro Phe Val Thr Val Asp Ser Asn Lys Pro Ile Arg Glu Leu Ile
    290                 295                 300                 
Ala Glu Ala Lys Ala Glu Val Thr Glu Glu Val Glu Asp Gly Lys Glu
305                 310                 315                 320 
Glu Asp Glu Glu Glu Glu Thr Glu Asn Ser Leu Pro Ile Pro Ala Ser
                325                 330                 335     
Lys Arg Ala Ser Ser Asp Leu Ser Ile Ala Ser Ser Glu Glu Asp Lys
            340                 345                 350         
Leu Ser Gln Asn Ala Cys Ile Leu Glu Ser Val Ser Glu Lys Thr Glu
        355                 360                 365             
Arg Ser Asn Ser Glu Asp Lys Leu Asn Ser Lys Ile Leu Asn Glu Lys
    370                 375                 380                 
Pro Thr Thr Asp Glu Pro Glu Lys Ala Val Glu Asp Ile Asn Glu His
385                 390                 395                 400 
Ile Thr Asp Ala Gln Leu Glu Ala Met Thr Glu Leu His Asp Arg Thr
                405                 410                 415     
Ala Val Ile Lys Glu Asn Glu Arg Glu Lys Arg Pro Lys Leu Glu Asn
            420                 425                 430         
Leu Pro Asp Thr Glu Asp Gln Glu Thr Val Asp Ile Asn Ser Val Ser
        435                 440                 445             
Glu Gly Lys Glu Asn Asn Ile Met Ile Thr Leu Glu Thr Asn Ile Glu
    450                 455                 460                 
His Asn Leu Lys Ser Glu Glu Glu Lys Asp Gln Glu Lys Gln Gln Met
465                 470                 475                 480 
Phe Glu Asn Lys Leu Ile Lys Ser Glu Glu Ile Lys Asp Thr Ile Leu
                485                 490                 495     
Gln Thr Val Asp Leu Val Ser Gln Glu Thr Gly Glu Lys Glu Ala Asn
            500                 505                 510         
Ile Gln Ala Val Asp Ser Glu Val Gly Leu Thr Lys Glu Asp Thr Gln
        515                 520                 525             
Glu Lys Leu Gly Glu Asp Asp Lys Thr Gln Lys Asp Val Ile Ser Asn
    530                 535                 540                 
Thr Ser Asp Val Ile Gly Thr Cys Glu Ala Ala Asp Val Ala Gln Lys
545                 550                 555                 560 
Val Asp Glu Asp Ser Ala Glu Asp Thr Gln Ser Asn Asp Gly Lys Glu
                565                 570                 575     
Val Val Glu Val Gly Gln Lys Leu Ile Asn Lys Pro Met Val Gly Pro
            580                 585                 590         
Glu Ala Gly Gly Thr Lys Glu Val Pro Ile Lys Glu Ile Val Glu Met
        595                 600                 605             
Asn Glu Ile Glu Glu Gly Lys Asn Lys Glu Gln Ala Ile Asn Ser Ser
    610                 615                 620                 
Glu Asn Ile Met Asp Ile Asn Glu Glu Pro Gly Thr Thr Glu Gly Glu
625                 630                 635                 640 
Glu Ile Thr Glu Ser Ser Ser Thr Glu Glu Met Glu Val Arg Ser Val
                645                 650                 655     
Val Ala Asp Thr Asp Gln Lys Ala Leu Gly Ser Glu Val Gln Asp Ala
            660                 665                 670         
Ser Lys Val Thr Thr Gln Ile Asp Lys Glu Lys Lys Glu Ile Pro Val
        675                 680                 685             
Ser Ile Lys Lys Glu Pro Glu Val Thr Val Val Ser Gln Pro Thr Glu
    690                 695                 700                 
Pro Gln Pro Val Leu Ile Pro Ser Ile Asn Ile Asn Ser Asp Ser Gly
705                 710                 715                 720 
Glu Asn Lys Glu Glu Ile Gly Ser Leu Ser Lys Thr Glu Thr Ile Leu
                725                 730                 735     
Pro Pro Glu Ser Glu Asn Pro Lys Glu Asn Asp Asn Asp Ser Gly Thr
            740                 745                 750         
Gly Ser Thr Ala Asp Thr Ser Ser Ile Asp Leu Asn Leu Ser Ile Ser
        755                 760                 765             
Ser Phe Leu Ser Lys Thr Lys Asp Ser Gly Ser Ile Ser Leu Gln Glu
    770                 775                 780                 
Thr Arg Arg Gln Lys Lys Thr Leu Lys Lys Thr Arg Lys Phe Ile Val
785                 790                 795                 800 
Asp Gly Val Glu Val Ser Val Thr Thr Ser Lys Ile Val Thr Asp Ser
                805                 810                 815     
Asp Ser Lys Thr Glu Glu Leu Arg Phe Leu Arg Arg Gln Glu Leu Arg
            820                 825                 830         
Glu Leu Arg Phe Leu Gln Lys Glu Glu Gln Arg Ala Gln Gln Gln Leu
        835                 840                 845             
Asn Ser Lys Leu Gln Gln Gln Arg Glu Gln Ile Phe Arg Arg Phe Glu
    850                 855                 860                 
Gln Glu Met Met Ser Lys Lys Arg Gln Tyr Asp Gln Glu Ile Glu Asn
865                 870                 875                 880 
Leu Glu Lys Gln Gln Lys Gln Thr Ile Glu Arg Leu Glu Gln Glu His
                885                 890                 895     
Thr Asn Arg Leu Arg Asp Glu Ala Lys Arg Ile Lys Gly Glu Gln Glu
            900                 905                 910         
Lys Glu Leu Ser Lys Phe Gln Asn Met Leu Lys Asn Arg Lys Lys Glu
        915                 920                 925             
Glu Gln Glu Phe Val Gln Lys Gln Gln Gln Glu Leu Asp Gly Ser Leu
    930                 935                 940                 
Lys Lys Ile Ile Gln Gln Gln Lys Ala Glu Leu Ala Asn Ile Glu Arg
945                 950                 955                 960 
Glu Cys Leu Asn Asn Lys Gln Gln Leu Met Arg Ala Arg Glu Ala Ala
                965                 970                 975     
Ile Trp Glu Leu Glu Glu Arg His Leu Gln Glu Lys His Gln Leu Leu
            980                 985                 990         
Lys Gln Gln Leu Lys Asp Gln Tyr Phe Met Gln Arg His Gln Leu Leu
        995                 1000                1005            
Lys Arg His Glu Lys Glu Thr Glu Gln Met Gln Arg Tyr Asn Gln Arg
    1010                1015                1020                
Leu Ile Glu Glu Leu Lys Asn Arg Gln Thr Gln Glu Arg Ala Arg Leu
1025                1030                1035                1040
Pro Lys Ile Gln Arg Ser Glu Ala Lys Thr Arg Met Ala Met Phe Lys
                1045                1050                1055    
Lys Ser Leu Arg Ile Asn Ser Thr Ala Thr Pro Asp Gln Asp Arg Asp
            1060                1065                1070        
Lys Ile Lys Gln Phe Ala Ala Gln Glu Glu Lys Arg Gln Lys Asn Glu
        1075                1080                1085            
Arg Met Ala Gln His Gln Lys His Glu Asn Gln Met Arg Asp Leu Gln
    1090                1095                1100                
Leu Gln Cys Glu Ala Asn Val Arg Glu Leu His Gln Leu Gln Asn Glu
1105                1110                1115                1120
Lys Cys His Leu Leu Val Glu His Glu Thr Gln Lys Leu Lys Glu Leu
                1125                1130                1135    
Asp Glu Glu His Ser Gln Glu Leu Lys Glu Trp Arg Glu Lys Leu Arg
            1140                1145                1150        
Pro Arg Lys Lys Thr Leu Glu Glu Glu Phe Ala Arg Lys Leu Gln Glu
        1155                1160                1165            
Gln Glu Val Phe Phe Lys Met Thr Gly Glu Ser Glu Cys Leu Asn Pro
    1170                1175                1180                
Ser Thr Gln Ser Arg Ile Ser Lys Phe Tyr Pro Ile Pro Ser Leu His
1185                1190                1195                1200
Ser Thr Gly Ser
                


<210> 8398
<211> 1235
<212> PRT
<213> Homo sapiens

<400> 8398
Met Ser Phe Phe Asn Phe Arg Lys Ile Phe Lys Leu Gly Ser Glu Lys
 1               5                  10                  15      
Lys Lys Lys Gln Tyr Glu His Val Lys Arg Asp Leu Asn Pro Glu Asp
            20                  25                  30          
Phe Trp Glu Ile Ile Gly Glu Leu Gly Asp Gly Ala Phe Gly Lys Val
        35                  40                  45              
Tyr Lys Ala Gln Asn Lys Glu Thr Ser Val Leu Ala Ala Ala Lys Val
    50                  55                  60                  
Ile Asp Thr Lys Ser Glu Glu Glu Leu Glu Asp Tyr Met Val Glu Ile
65                  70                  75                  80  
Asp Ile Leu Ala Ser Cys Asp His Pro Asn Ile Val Lys Leu Leu Asp
                85                  90                  95      
Ala Phe Tyr Tyr Glu Asn Asn Leu Trp Ile Leu Ile Glu Phe Cys Ala
            100                 105                 110         
Gly Gly Ala Val Asp Ala Val Met Leu Glu Leu Glu Arg Pro Leu Thr
        115                 120                 125             
Glu Ser Gln Ile Gln Val Val Cys Lys Gln Thr Leu Asp Ala Leu Asn
    130                 135                 140                 
Tyr Leu His Asp Asn Lys Ile Ile His Arg Asp Leu Lys Ala Gly Asn
145                 150                 155                 160 
Ile Leu Phe Thr Leu Asp Gly Asp Ile Lys Leu Ala Asp Phe Gly Val
                165                 170                 175     
Ser Ala Lys Asn Thr Arg Thr Ile Gln Arg Arg Asp Ser Phe Ile Gly
            180                 185                 190         
Thr Pro Tyr Trp Met Ala Pro Glu Val Val Met Cys Glu Thr Ser Lys
        195                 200                 205             
Asp Arg Pro Tyr Asp Tyr Lys Ala Asp Val Trp Ser Leu Gly Ile Thr
    210                 215                 220                 
Leu Ile Glu Met Ala Glu Ile Glu Pro Pro His His Glu Leu Asn Pro
225                 230                 235                 240 
Met Arg Val Leu Leu Lys Ile Ala Lys Ser Glu Pro Pro Thr Leu Ala
                245                 250                 255     
Gln Pro Ser Arg Trp Ser Ser Asn Phe Lys Asp Phe Leu Lys Lys Cys
            260                 265                 270         
Leu Glu Lys Asn Val Asp Ala Arg Trp Thr Thr Ser Gln Leu Leu Gln
        275                 280                 285             
His Pro Phe Val Thr Val Asp Ser Asn Lys Pro Ile Arg Glu Leu Ile
    290                 295                 300                 
Ala Glu Ala Lys Ala Glu Val Thr Glu Glu Val Glu Asp Gly Lys Glu
305                 310                 315                 320 
Glu Asp Glu Glu Glu Glu Thr Glu Asn Ser Leu Pro Ile Pro Ala Ser
                325                 330                 335     
Lys Arg Ala Ser Ser Asp Leu Ser Ile Ala Ser Ser Glu Glu Asp Lys
            340                 345                 350         
Leu Ser Gln Asn Ala Cys Ile Leu Glu Ser Val Ser Glu Lys Thr Glu
        355                 360                 365             
Arg Ser Asn Ser Glu Asp Lys Leu Asn Ser Lys Ile Leu Asn Glu Lys
    370                 375                 380                 
Pro Thr Thr Asp Glu Pro Glu Lys Ala Val Glu Asp Ile Asn Glu His
385                 390                 395                 400 
Ile Thr Asp Ala Gln Leu Glu Ala Met Thr Glu Leu His Asp Arg Thr
                405                 410                 415     
Ala Val Ile Lys Glu Asn Glu Arg Glu Lys Arg Pro Lys Leu Glu Asn
            420                 425                 430         
Leu Pro Asp Thr Glu Asp Gln Glu Thr Val Asp Ile Asn Ser Val Ser
        435                 440                 445             
Glu Gly Lys Glu Asn Asn Ile Met Ile Thr Leu Glu Thr Asn Ile Glu
    450                 455                 460                 
His Asn Leu Lys Ser Glu Glu Glu Lys Asp Gln Glu Lys Gln Gln Met
465                 470                 475                 480 
Phe Glu Asn Lys Leu Ile Lys Ser Glu Glu Ile Lys Asp Thr Ile Leu
                485                 490                 495     
Gln Thr Val Asp Leu Val Ser Gln Glu Thr Gly Glu Lys Glu Ala Asn
            500                 505                 510         
Ile Gln Ala Val Asp Ser Glu Val Gly Leu Thr Lys Glu Asp Thr Gln
        515                 520                 525             
Glu Lys Leu Gly Glu Asp Asp Lys Thr Gln Lys Asp Val Ile Ser Asn
    530                 535                 540                 
Thr Ser Asp Val Ile Gly Thr Cys Glu Ala Ala Asp Val Ala Gln Lys
545                 550                 555                 560 
Val Asp Glu Asp Ser Ala Glu Asp Thr Gln Ser Asn Asp Gly Lys Glu
                565                 570                 575     
Val Val Glu Val Gly Gln Lys Leu Ile Asn Lys Pro Met Val Gly Pro
            580                 585                 590         
Glu Ala Gly Gly Thr Lys Glu Val Pro Ile Lys Glu Ile Val Glu Met
        595                 600                 605             
Asn Glu Ile Glu Glu Gly Lys Asn Lys Glu Gln Ala Ile Asn Ser Ser
    610                 615                 620                 
Glu Asn Ile Met Asp Ile Asn Glu Glu Pro Gly Thr Thr Glu Gly Glu
625                 630                 635                 640 
Glu Ile Thr Glu Ser Ser Ser Thr Glu Glu Met Glu Val Arg Ser Val
                645                 650                 655     
Val Ala Asp Thr Asp Gln Lys Ala Leu Gly Ser Glu Val Gln Asp Ala
            660                 665                 670         
Ser Lys Val Thr Thr Gln Ile Asp Lys Glu Lys Lys Glu Ile Pro Val
        675                 680                 685             
Ser Ile Lys Lys Glu Pro Glu Val Thr Val Val Ser Gln Pro Thr Glu
    690                 695                 700                 
Pro Gln Pro Val Leu Ile Pro Ser Ile Asn Ile Asn Ser Asp Ser Gly
705                 710                 715                 720 
Glu Asn Lys Glu Glu Ile Gly Ser Leu Ser Lys Thr Glu Thr Ile Leu
                725                 730                 735     
Pro Pro Glu Ser Glu Asn Pro Lys Glu Asn Asp Asn Asp Ser Gly Thr
            740                 745                 750         
Gly Ser Thr Ala Asp Thr Ser Ser Ile Asp Leu Asn Leu Ser Ile Ser
        755                 760                 765             
Ser Phe Leu Ser Lys Thr Lys Asp Ser Gly Ser Ile Ser Leu Gln Glu
    770                 775                 780                 
Thr Arg Arg Gln Lys Lys Thr Leu Lys Lys Thr Arg Lys Phe Ile Val
785                 790                 795                 800 
Asp Gly Val Glu Val Ser Val Thr Thr Ser Lys Ile Val Thr Asp Ser
                805                 810                 815     
Asp Ser Lys Thr Glu Glu Leu Arg Phe Leu Arg Arg Gln Glu Leu Arg
            820                 825                 830         
Glu Leu Arg Phe Leu Gln Lys Glu Glu Gln Arg Ala Gln Gln Gln Leu
        835                 840                 845             
Asn Ser Lys Leu Gln Gln Gln Arg Glu Gln Ile Phe Arg Arg Phe Glu
    850                 855                 860                 
Gln Glu Met Met Ser Lys Lys Arg Gln Tyr Asp Gln Glu Ile Glu Asn
865                 870                 875                 880 
Leu Glu Lys Gln Gln Lys Gln Thr Ile Glu Arg Leu Glu Gln Glu His
                885                 890                 895     
Thr Asn Arg Leu Arg Asp Glu Ala Lys Arg Ile Lys Gly Glu Gln Glu
            900                 905                 910         
Lys Glu Leu Ser Lys Phe Gln Asn Met Leu Lys Asn Arg Lys Lys Glu
        915                 920                 925             
Val Ile Asn Glu Val Glu Lys Ala Pro Lys Glu Leu Arg Lys Glu Leu
    930                 935                 940                 
Met Lys Arg Arg Lys Glu Glu Leu Ala Gln Ser Gln His Ala Gln Glu
945                 950                 955                 960 
Gln Glu Phe Val Gln Lys Gln Gln Gln Glu Leu Asp Gly Ser Leu Lys
                965                 970                 975     
Lys Ile Ile Gln Gln Gln Lys Ala Glu Leu Ala Asn Ile Glu Arg Glu
            980                 985                 990         
Cys Leu Asn Asn Lys Gln Gln Leu Met Arg Ala Arg Glu Ala Ala Ile
        995                 1000                1005            
Trp Glu Leu Glu Glu Arg His Leu Gln Glu Lys His Gln Leu Leu Lys
    1010                1015                1020                
Gln Gln Leu Lys Asp Gln Tyr Phe Met Gln Arg His Gln Leu Leu Lys
1025                1030                1035                1040
Arg His Glu Lys Glu Thr Glu Gln Met Gln Arg Tyr Asn Gln Arg Leu
                1045                1050                1055    
Ile Glu Glu Leu Lys Asn Arg Gln Thr Gln Glu Arg Ala Arg Leu Pro
            1060                1065                1070        
Lys Ile Gln Arg Ser Glu Ala Lys Thr Arg Met Ala Met Phe Lys Lys
        1075                1080                1085            
Ser Leu Arg Ile Asn Ser Thr Ala Thr Pro Asp Gln Asp Arg Asp Lys
    1090                1095                1100                
Ile Lys Gln Phe Ala Ala Gln Glu Glu Lys Arg Gln Lys Asn Glu Arg
1105                1110                1115                1120
Met Ala Gln His Gln Lys His Glu Asn Gln Met Arg Asp Leu Gln Leu
                1125                1130                1135    
Gln Cys Glu Ala Asn Val Arg Glu Leu His Gln Leu Gln Asn Glu Lys
            1140                1145                1150        
Cys His Leu Leu Val Glu His Glu Thr Gln Lys Leu Lys Glu Leu Asp
        1155                1160                1165            
Glu Glu His Ser Gln Glu Leu Lys Glu Trp Arg Glu Lys Leu Arg Pro
    1170                1175                1180                
Arg Lys Lys Thr Leu Glu Glu Glu Phe Ala Arg Lys Leu Gln Glu Gln
1185                1190                1195                1200
Glu Val Phe Phe Lys Met Thr Gly Glu Ser Glu Cys Leu Asn Pro Ser
                1205                1210                1215    
Thr Gln Ser Arg Ile Ser Lys Phe Tyr Pro Ile Pro Ser Leu His Ser
            1220                1225                1230        
Thr Gly Ser
        1235


<210> 8399
<211> 1152
<212> PRT
<213> Homo sapiens

<400> 8399
Met Ser Phe Phe Ser Phe Arg Lys Ile Phe Lys Leu Gly Ser Glu Lys
 1               5                  10                  15      
Lys Lys Lys Gln Tyr Glu His Val Lys Arg Asp Leu Asn Pro Glu Asp
            20                  25                  30          
Phe Trp Glu Ile Ile Gly Glu Leu Gly Asp Gly Ala Phe Gly Lys Val
        35                  40                  45              
Tyr Lys Ala Gln Asn Lys Glu Thr Ser Val Leu Ala Ala Ala Lys Val
    50                  55                  60                  
Ile Asp Thr Lys Ser Glu Glu Glu Leu Glu Asp Tyr Met Val Glu Ile
65                  70                  75                  80  
Asp Ile Leu Ala Ser Cys Asp His Pro Asn Ile Val Lys Leu Leu Asp
                85                  90                  95      
Ala Phe Tyr Tyr Glu Asn Asn Leu Trp Ile Leu Ile Glu Phe Cys Ala
            100                 105                 110         
Gly Gly Ala Val Asp Ala Val Met Leu Glu Leu Glu Arg Pro Leu Thr
        115                 120                 125             
Glu Ser Gln Ile Gln Val Val Cys Lys Gln Thr Leu Asp Ala Leu Asn
    130                 135                 140                 
Tyr Leu His Asp Asn Lys Ile Ile His Arg Asp Leu Lys Ala Gly Asn
145                 150                 155                 160 
Ile Leu Phe Thr Leu Asp Gly Asp Ile Lys Leu Ala Asp Phe Gly Val
                165                 170                 175     
Ser Ala Lys Asn Thr Arg Thr Ile Gln Arg Arg Asp Ser Phe Ile Gly
            180                 185                 190         
Thr Pro Tyr Trp Met Ala Pro Glu Val Val Met Cys Glu Thr Ser Lys
        195                 200                 205             
Asp Arg Pro Tyr Asp Tyr Lys Ala Asp Val Trp Ser Leu Gly Ile Thr
    210                 215                 220                 
Leu Ile Glu Met Ala Glu Ile Glu Pro Pro His His Glu Leu Asn Pro
225                 230                 235                 240 
Met Arg Val Leu Leu Lys Ile Ala Lys Ser Glu Pro Pro Thr Leu Ala
                245                 250                 255     
Gln Pro Ser Arg Trp Ser Ser Asn Phe Lys Asp Phe Leu Lys Lys Cys
            260                 265                 270         
Leu Glu Lys Asn Val Asp Ala Arg Trp Thr Thr Ser Gln Leu Leu Gln
        275                 280                 285             
His Pro Phe Val Thr Val Asp Ser Asn Lys Pro Ile Arg Glu Leu Ile
    290                 295                 300                 
Ala Glu Ala Lys Ala Glu Val Thr Glu Glu Val Glu Asp Gly Lys Glu
305                 310                 315                 320 
Glu Asp Glu Glu Glu Glu Thr Glu Asn Ser Leu Pro Ile Pro Ala Ser
                325                 330                 335     
Lys Arg Ala Ser Ser Asp Leu Ser Ile Ala Ser Ser Glu Glu Asp Lys
            340                 345                 350         
Leu Ser Gln Asn Ala Cys Ile Leu Glu Ser Val Ser Glu Lys Thr Glu
        355                 360                 365             
Arg Ser Asn Ser Glu Asp Lys Leu Asn Ser Lys Ile Leu Asn Glu Lys
    370                 375                 380                 
Pro Thr Thr Asp Glu Pro Glu Lys Ala Val Glu Asp Ile Asn Glu His
385                 390                 395                 400 
Ile Thr Asp Ala Gln Leu Glu Ala Met Thr Glu Leu His Asp Arg Thr
                405                 410                 415     
Ala Val Ile Lys Glu Asn Glu Arg Glu Lys Arg Pro Lys Leu Glu Asn
            420                 425                 430         
Leu Pro Asp Thr Glu Asp Gln Glu Thr Val Asp Ile Asn Ser Val Ser
        435                 440                 445             
Glu Gly Lys Glu Asn Asn Ile Met Ile Thr Leu Glu Thr Asn Ile Glu
    450                 455                 460                 
His Asn Leu Lys Ser Glu Glu Glu Lys Asp Gln Glu Lys Gln Gln Met
465                 470                 475                 480 
Phe Glu Asn Lys Leu Ile Lys Ser Glu Glu Ile Lys Asp Thr Ile Leu
                485                 490                 495     
Gln Thr Val Asp Leu Val Ser Gln Glu Thr Gly Glu Lys Glu Ala Asn
            500                 505                 510         
Ile Gln Ala Val Asp Ser Glu Val Gly Leu Thr Lys Glu Asp Thr Gln
        515                 520                 525             
Glu Lys Leu Gly Glu Asp Asp Lys Thr Gln Lys Asp Val Ile Ser Asn
    530                 535                 540                 
Thr Ser Asp Val Ile Gly Thr Cys Glu Ala Ala Asp Val Ala Gln Lys
545                 550                 555                 560 
Val Asp Glu Asp Ser Ala Glu Asp Thr Gln Ser Asn Asp Gly Lys Glu
                565                 570                 575     
Val Val Glu Val Gly Gln Lys Leu Ile Asn Lys Pro Met Val Gly Pro
            580                 585                 590         
Glu Ala Gly Gly Thr Lys Glu Val Pro Ile Lys Glu Ile Val Glu Met
        595                 600                 605             
Asn Glu Ile Glu Glu Gly Lys Asn Lys Glu Gln Ala Ile Asn Ser Ser
    610                 615                 620                 
Glu Asn Ile Met Asp Ile Asn Glu Glu Pro Gly Thr Thr Glu Gly Glu
625                 630                 635                 640 
Glu Ile Thr Glu Ser Ser Ser Thr Glu Glu Met Glu Val Arg Ser Val
                645                 650                 655     
Val Ala Asp Thr Asp Gln Lys Ala Leu Gly Ser Glu Val Gln Asp Ala
            660                 665                 670         
Ser Lys Val Thr Thr Gln Ile Asp Lys Glu Lys Lys Glu Ile Pro Val
        675                 680                 685             
Ser Ile Lys Lys Glu Pro Glu Val Thr Val Val Ser Gln Pro Thr Glu
    690                 695                 700                 
Pro Gln Pro Val Leu Ile Pro Ser Ile Asn Ile Asn Ser Asp Ser Gly
705                 710                 715                 720 
Glu Asn Lys Glu Glu Ile Gly Ser Leu Ser Lys Thr Glu Thr Ile Leu
                725                 730                 735     
Pro Pro Glu Ser Glu Asn Pro Lys Glu Asn Asp Asn Asp Ser Gly Thr
            740                 745                 750         
Gly Ser Thr Ala Asp Thr Ser Ser Ile Asp Leu Asn Leu Ser Ile Ser
        755                 760                 765             
Ser Phe Leu Ser Lys Thr Lys Asp Ser Gly Ser Ile Ser Leu Gln Glu
    770                 775                 780                 
Thr Arg Arg Gln Lys Lys Thr Leu Lys Lys Thr Arg Lys Phe Ile Val
785                 790                 795                 800 
Asp Gly Val Glu Val Ser Val Thr Thr Ser Lys Ile Val Thr Asp Ser
                805                 810                 815     
Asp Ser Lys Thr Glu Glu Leu Arg Phe Leu Arg Arg Gln Glu Leu Arg
            820                 825                 830         
Glu Leu Arg Phe Leu Gln Lys Glu Glu Gln Arg Ala Gln Gln Gln Leu
        835                 840                 845             
Asn Ser Lys Leu Gln Gln Gln Arg Glu Gln Ile Phe Arg Arg Phe Glu
    850                 855                 860                 
Gln Glu Met Met Ser Lys Lys Arg Gln Tyr Asp Gln Glu Ile Glu Asn
865                 870                 875                 880 
Leu Glu Lys Gln Gln Lys Gln Thr Ile Glu Arg Leu Glu Gln Glu His
                885                 890                 895     
Thr Asn Arg Leu Arg Asp Glu Ala Lys Arg Ile Lys Gly Glu Gln Glu
            900                 905                 910         
Lys Glu Leu Ser Lys Phe Gln Asn Met Leu Lys Asn Arg Lys Lys Glu
        915                 920                 925             
Glu Gln Glu Phe Val Gln Lys Gln Gln Gln Glu Leu Asp Gly Ser Leu
    930                 935                 940                 
Lys Lys Ile Ile Gln Gln Gln Lys Ala Glu Leu Ala Asn Ile Glu Arg
945                 950                 955                 960 
Glu Cys Leu Asn Asn Lys Gln Gln Leu Met Arg Ala Arg Glu Ala Ala
                965                 970                 975     
Ile Trp Glu Leu Glu Glu Arg His Leu Gln Glu Lys His Gln Leu Leu
            980                 985                 990         
Lys Gln Gln Leu Lys Asp Gln Tyr Phe Met Gln Arg His Gln Leu Leu
        995                 1000                1005            
Lys Arg His Glu Lys Glu Thr Glu Gln Met Gln Arg Tyr Asn Gln Arg
    1010                1015                1020                
Leu Ile Glu Glu Leu Lys Asn Arg Gln Thr Gln Glu Arg Ala Arg Leu
1025                1030                1035                1040
Pro Lys Ile Gln Arg Ser Glu Ala Lys Thr Arg Met Ala Met Phe Lys
                1045                1050                1055    
Lys Ser Leu Arg Ile Asn Ser Thr Ala Thr Pro Asp Gln Asp Arg Asp
            1060                1065                1070        
Lys Ile Lys Gln Phe Ala Ala Gln Glu Glu Lys Arg Gln Lys Asn Glu
        1075                1080                1085            
Arg Met Ala Gln His Gln Lys His Glu Asn Gln Met Arg Asp Leu Gln
    1090                1095                1100                
Leu Gln Cys Glu Ala Asn Val Arg Glu Leu His Gln Leu Gln Asn Glu
1105                1110                1115                1120
Lys Cys His Leu Leu Val Glu His Glu Thr Gln Lys Leu Lys Glu Leu
                1125                1130                1135    
Asp Glu Glu His Thr Arg Ile Lys Gly Val Glu Arg Glu Ile Glu Thr
            1140                1145                1150        


<210> 8400
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8400
Met Asp Asn Leu Glu Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro
 1               5                  10                  15      
Ile Lys Tyr Ser Gln Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp
            20                  25                  30          
Arg Val Pro Glu Glu Glu Lys Asp Thr Asn Val Gln Val Leu Met Val
        35                  40                  45              
Leu Gly Ala Gly Arg Gly Pro Leu Val Asn Ala Ser Leu Arg Ala Ala
    50                  55                  60                  
Lys Gln Ala Asp Arg Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro
65                  70                  75                  80  
Asn Ala Val Val Thr Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser
                85                  90                  95      
Gln Val Thr Val Val Ser Ser Asp Met Arg Glu Trp Val Ala Pro Glu
            100                 105                 110         
Lys Ala Asp Ile Ile Val Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn
        115                 120                 125             
Glu Leu Ser Pro Glu Cys Leu Asp Gly Ala Gln His Phe Leu Lys Asp
    130                 135                 140                 
Val Leu Met Val Ser His Pro Leu Pro Tyr
145                 150                 


<210> 8401
<211> 637
<212> PRT
<213> Homo sapiens

<400> 8401
Met Ala Ala Met Ala Val Gly Gly Ala Gly Gly Ser Arg Val Ser Ser
 1               5                  10                  15      
Gly Arg Asp Leu Asn Cys Val Pro Glu Ile Ala Asp Thr Leu Gly Ala
            20                  25                  30          
Val Ala Lys Gln Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro
        35                  40                  45              
Arg Phe Lys Arg Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly
    50                  55                  60                  
Pro Gln Thr Arg Ser Asp Leu Leu Leu Ser Gly Arg Asp Trp Asn Thr
65                  70                  75                  80  
Leu Ile Val Gly Lys Leu Ser Pro Trp Ile Arg Pro Asp Ser Lys Val
                85                  90                  95      
Glu Lys Ile Arg Arg Asn Ser Glu Ala Ala Met Leu Gln Glu Leu Asn
            100                 105                 110         
Phe Gly Ala Tyr Leu Gly Leu Pro Ala Phe Leu Leu Pro Leu Asn Gln
        115                 120                 125             
Glu Asp Asn Thr Asn Leu Ala Arg Val Leu Thr Asn His Ile His Thr
    130                 135                 140                 
Gly His His Ser Ser Met Phe Trp Met Arg Val Pro Leu Val Ala Pro
145                 150                 155                 160 
Glu Asp Leu Arg Asp Asp Ile Ile Glu Asn Ala Pro Thr Thr His Thr
                165                 170                 175     
Glu Glu Tyr Ser Gly Glu Glu Lys Thr Trp Met Trp Trp His Asn Phe
            180                 185                 190         
Arg Thr Leu Cys Asp Tyr Ser Lys Arg Ile Ala Val Ala Leu Glu Ile
        195                 200                 205             
Gly Ala Asp Leu Pro Ser Asn His Val Ile Asp Arg Trp Leu Gly Glu
    210                 215                 220                 
Pro Ile Lys Ala Ala Ile Leu Pro Thr Ser Ile Phe Leu Thr Asn Lys
225                 230                 235                 240 
Lys Gly Phe Pro Val Leu Ser Lys Met His Gln Arg Leu Ile Phe Arg
                245                 250                 255     
Leu Leu Lys Leu Glu Val Gln Phe Ile Ile Thr Gly Thr Asn His His
            260                 265                 270         
Ser Glu Lys Glu Phe Cys Ser Tyr Leu Gln Tyr Leu Glu Tyr Leu Ser
        275                 280                 285             
Gln Asn Arg Pro Pro Pro Asn Ala Tyr Glu Leu Phe Ala Lys Gly Tyr
    290                 295                 300                 
Glu Asp Tyr Leu Gln Ser Pro Leu Gln Pro Leu Met Asp Asn Leu Glu
305                 310                 315                 320 
Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro Ile Lys Tyr Ser Gln
                325                 330                 335     
Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp Arg Val Pro Glu Glu
            340                 345                 350         
Glu Lys Asp Thr Asn Val Gln Val Leu Met Val Leu Gly Ala Gly Arg
        355                 360                 365             
Gly Pro Leu Val Asn Ala Ser Leu Arg Ala Ala Lys Gln Ala Asp Arg
    370                 375                 380                 
Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro Asn Ala Val Val Thr
385                 390                 395                 400 
Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser Gln Val Thr Val Val
                405                 410                 415     
Ser Ser Asp Met Arg Glu Trp Val Ala Pro Glu Lys Ala Asp Ile Ile
            420                 425                 430         
Val Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn Glu Leu Ser Pro Glu
        435                 440                 445             
Cys Leu Asp Gly Ala Gln His Phe Leu Lys Asp Asp Gly Val Ser Ile
    450                 455                 460                 
Pro Gly Glu Tyr Thr Ser Phe Leu Ala Pro Ile Ser Ser Ser Lys Leu
465                 470                 475                 480 
Tyr Asn Glu Val Arg Ala Cys Arg Glu Lys Asp Arg Asp Pro Glu Ala
                485                 490                 495     
Gln Phe Glu Met Pro Tyr Val Val Arg Leu His Asn Phe His Gln Leu
            500                 505                 510         
Ser Ala Pro Gln Pro Cys Phe Thr Phe Ser His Pro Asn Arg Asp Pro
        515                 520                 525             
Met Ile Asp Asn Asn Arg Tyr Cys Thr Leu Glu Phe Pro Val Glu Val
    530                 535                 540                 
Asn Thr Val Leu His Gly Phe Ala Gly Tyr Phe Glu Thr Val Leu Tyr
545                 550                 555                 560 
Gln Asp Ile Thr Leu Ser Ile Arg Pro Glu Thr His Ser Pro Gly Met
                565                 570                 575     
Phe Ser Trp Phe Pro Ile Leu Phe Pro Ile Lys Gln Pro Ile Thr Val
            580                 585                 590         
Arg Glu Gly Gln Thr Ile Cys Val Arg Phe Trp Arg Cys Ser Asn Ser
        595                 600                 605             
Lys Lys Val Trp Tyr Glu Trp Ala Val Thr Ala Pro Val Cys Ser Ala
    610                 615                 620                 
Ile His Asn Pro Thr Gly Arg Ser Tyr Thr Ile Gly Leu
625                 630                 635         


<210> 8402
<211> 372
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 53, 102
<223> Xaa = Any Amino Acid

<400> 8402
Met Ser Ala Asp Cys Ala Leu Leu Ile Ile Ala Pro Gly Val Gly Glu
 1               5                  10                  15      
Phe Glu Val Gly Ile Ser Lys Asn Gly Gln Thr Gln Glu His Ala Leu
            20                  25                  30          
Leu Ala Tyr Thr Leu Gly Val Lys Gln Leu Leu Val Gly Val Asn Lys
        35                  40                  45              
Met Asp Ser Thr Xaa Ser Pro Tyr His Gln Met Arg Tyr Lys Glu Ile
    50                  55                  60                  
Ser Thr Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Thr Phe
65                  70                  75                  80  
Val Pro Ile Ser Gly Trp His Gly Asp Asn Met Leu Glu Pro Ser Gly
                85                  90                  95      
Asn Met Pro Trp Phe Xaa Glu Trp Lys Val Thr Tyr Lys Asp Ser Asn
            100                 105                 110         
Ala Ser Gly Thr Thr Leu Leu Glu Ala Leu Asp Phe Ile Leu Pro Leu
        115                 120                 125             
Thr His Pro Thr Tyr Glu Pro Leu Cys Leu Cys Leu Gln Asp Val Tyr
    130                 135                 140                 
Lys Ile Val Gly Ile Gly Thr Val Pro Val Gly Arg Ala Glu Thr Gly
145                 150                 155                 160 
Val Leu Lys Pro Gly Met Val Val Ser Phe Ala Pro Val Asn Val Arg
                165                 170                 175     
Ile Glu Val Lys Ser Ile Glu Met His His Glu Ala Leu Ser Glu Ser
            180                 185                 190         
Leu Pro Gly Asp Asn Val Gly Leu Asn Val Asn Lys Lys Lys Lys Lys
        195                 200                 205             
Asn Ala Ser Ala Lys Asp Val His His Gly Asn Val Ala Gly Asp Ser
    210                 215                 220                 
Lys Asn Asp Pro Pro Met Glu Ala Ser Gly Phe Thr Ala Gln Val Ile
225                 230                 235                 240 
Ile Leu Asn His Leu Gly Gln Ile Ser Ala Gly Tyr Ala Pro Ala Leu
                245                 250                 255     
Asp Cys His Thr Ser Gln Ile Pro Tyr Lys Cys Ser Glu Gln Lys Glu
            260                 265                 270         
Lys Val Thr Ile Leu Thr Ser Val Asn Pro Ser Ser Pro Tyr Thr Asn
        275                 280                 285             
Ser Ser Arg Thr Gln Pro Met Ser Ala Thr Leu Arg Glu Arg Leu Arg
    290                 295                 300                 
Lys Ala Arg Ser Ser Phe Ser Ser Cys Tyr Asn Val Val Lys Leu Leu
305                 310                 315                 320 
Lys Val Glu Asn Glu Glu Asn Asp Gln Thr Phe Ser Glu Lys Pro Ala
                325                 330                 335     
Ser Ser Thr Glu Glu Asn Cys Leu Glu Phe Gln Glu Ser Phe Lys His
            340                 345                 350         
Ile Asp Ser Glu Phe Glu Glu Asn Ile Asn Leu Lys Asn Thr Leu Lys
        355                 360                 365             
Asn Gln Cys Leu
    370         


<210> 8403
<211> 305
<212> PRT
<213> Homo sapiens

<400> 8403
Met Lys Gly Gly Asn Leu Asp Leu Asn Gly Leu Asp His Leu Thr Ala
 1               5                  10                  15      
Ala His Val Met Thr Ile Phe Val Ala Asp Glu Asp Asp Glu Glu Glu
            20                  25                  30          
Asp Asp Ser Pro Pro Glu Arg Gln Ile Val Val Gly Ile Cys Ser Met
        35                  40                  45              
Ala Lys Lys Ser Lys Ser Lys Pro Met Lys Glu Ile Leu Glu Trp Val
    50                  55                  60                  
Ser Leu Phe Lys Tyr Ile Thr Val Val Val Phe Glu Glu Glu Val Ile
65                  70                  75                  80  
Leu Arg Glu Pro Val Glu Asn Trp Pro Leu Cys Asp Cys Leu Phe Ser
                85                  90                  95      
Leu His Ser Lys Gly Phe Pro Leu Asp Lys Val Val Ala Tyr Ala Lys
            100                 105                 110         
Leu Arg Asn Pro Phe Val Ile Asn Asp Leu Asn Met Gln Tyr Leu Ile
        115                 120                 125             
Gln Asp Trp Arg Glu Val Tyr Ser Ile Leu Gln Ala Glu Val Ile Leu
    130                 135                 140                 
Leu Pro Cys Tyr Ala Ile Leu Asn Arg Asp Pro Asn Asn Pro Lys Glu
145                 150                 155                 160 
Cys Asn Leu Ile Glu Gly Glu Asp His Val Glu Val Asn Glu Glu Val
                165                 170                 175     
Phe Gln Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu Asp His Asn
            180                 185                 190         
Val Tyr Ile Tyr Tyr Pro Thr Ser Ala Gly Ser Gly Ser Gln Arg Leu
        195                 200                 205             
Phe Arg Lys Ile Gly Ser Arg Asn Thr Ala Glu His Ala Arg Arg Ser
    210                 215                 220                 
Gly Asn Cys Leu Ser Ala Gly Thr Ala Arg Ile Ser Asp Pro Glu Glu
225                 230                 235                 240 
Tyr Gly Ser Pro Asp Arg Arg Leu Asn Ala Phe Cys Trp Cys Ser Lys
                245                 250                 255     
Leu Phe Leu Ser Ile Asp Ile Val Gly Asp Leu Lys Asp Ser Glu Ser
            260                 265                 270         
Met Ser Phe Ser Asp Leu Glu Asn Trp Ala Val Ala Asn Ser Ser Glu
        275                 280                 285             
Pro Gln Leu Glu Asp Ala Lys Arg Glu Ile Ser Asn Ser Ser Leu Phe
    290                 295                 300                 
Trp
305 


<210> 8404
<211> 1123
<212> PRT
<213> Homo sapiens

<400> 8404
Met Trp Gly Asp Ser Arg Pro Ala Asn Arg Thr Gly Pro Phe Arg Gly
 1               5                  10                  15      
Ser Gln Glu Glu Arg Phe Ala Pro Gly Trp Asn Arg Asp Tyr Pro Pro
            20                  25                  30          
Pro Pro Leu Lys Ser His Ala Gln Glu Arg His Ser Gly Asn Phe Pro
        35                  40                  45              
Gly Arg Asp Ser Leu Pro Phe Asp Phe Gln Gly His Ser Gly Pro Pro
    50                  55                  60                  
Phe Ala Asn Val Glu Glu His Ser Phe Ser Tyr Gly Ala Arg Asp Gly
65                  70                  75                  80  
Pro His Gly Asp Tyr Arg Gly Gly Glu Gly Pro Gly His Asp Phe Arg
                85                  90                  95      
Gly Gly Asp Phe Ser Ser Ser Asp Phe Gln Ser Arg Asp Ser Ser Gln
            100                 105                 110         
Leu Asp Phe Arg Gly Arg Asp Ile His Ser Gly Asp Phe Arg Asp Arg
        115                 120                 125             
Glu Gly Pro Pro Met Asp Tyr Arg Gly Gly Asp Gly Thr Ser Met Asp
    130                 135                 140                 
Tyr Arg Gly Arg Glu Ala Pro His Met Asn Tyr Arg Asp Arg Asp Ala
145                 150                 155                 160 
His Ala Val Asp Phe Arg Gly Arg Asp Ala Pro Pro Ser Asp Phe Arg
                165                 170                 175     
Gly Arg Gly Thr Tyr Asp Leu Asp Phe Arg Gly Arg Asp Gly Ser His
            180                 185                 190         
Ala Asp Phe Arg Gly Arg Asp Leu Ser Asp Leu Asp Phe Arg Ala Arg
        195                 200                 205             
Glu Gln Ser Arg Ser Asp Phe Arg Asn Arg Asp Val Ser Asp Leu Asp
    210                 215                 220                 
Phe Arg Asp Lys Asp Gly Thr Gln Val Asp Phe Arg Gly Arg Gly Ser
225                 230                 235                 240 
Gly Thr Thr Asp Leu Asp Phe Arg Asp Arg Asp Thr Pro His Ser Asp
                245                 250                 255     
Phe Arg Gly Arg His Arg Ser Arg Thr Asp Gln Asp Phe Arg Gly Arg
            260                 265                 270         
Glu Met Gly Ser Cys Met Glu Phe Lys Asp Arg Glu Met Pro Pro Val
        275                 280                 285             
Asp Pro Asn Ile Leu Asp Tyr Ile Gln Pro Ser Thr Gln Asp Arg Glu
    290                 295                 300                 
His Ser Gly Met Asn Val Asn Arg Arg Glu Glu Ser Thr His Asp His
305                 310                 315                 320 
Thr Ile Glu Arg Pro Ala Phe Gly Ile Gln Lys Gly Glu Phe Glu His
                325                 330                 335     
Ser Glu Thr Arg Glu Gly Glu Thr Gln Gly Val Ala Phe Glu His Glu
            340                 345                 350         
Ser Pro Ala Asp Phe Gln Asn Ser Gln Ser Pro Val Gln Asp Gln Asp
        355                 360                 365             
Lys Ser Gln Leu Ser Gly Arg Glu Glu Gln Ser Ser Asp Ala Gly Leu
    370                 375                 380                 
Phe Lys Glu Glu Gly Gly Leu Asp Phe Leu Gly Arg Gln Asp Thr Asp
385                 390                 395                 400 
Tyr Arg Ser Met Glu Tyr Arg Asp Val Asp His Arg Leu Pro Gly Ser
                405                 410                 415     
Gln Met Phe Gly Tyr Gly Gln Ser Lys Ser Phe Pro Glu Gly Lys Thr
            420                 425                 430         
Ala Arg Asp Ala Gln Arg Asp Leu Gln Asp Gln Asp Tyr Arg Thr Gly
        435                 440                 445             
Pro Ser Glu Glu Lys Pro Ser Arg Leu Ile Arg Leu Ser Gly Val Pro
    450                 455                 460                 
Glu Asp Ala Thr Lys Glu Glu Ile Leu Asn Ala Phe Arg Thr Pro Asp
465                 470                 475                 480 
Gly Met Pro Val Lys Asn Leu Gln Leu Lys Glu Tyr Asn Thr Gly Tyr
                485                 490                 495     
Asp Tyr Gly Tyr Val Cys Val Glu Phe Ser Leu Leu Glu Asp Ala Ile
            500                 505                 510         
Gly Cys Met Glu Ala Asn Gln Gly Thr Leu Met Ile Gln Asp Lys Glu
        515                 520                 525             
Val Thr Leu Glu Tyr Val Ser Ser Leu Asp Phe Trp Tyr Cys Lys Arg
    530                 535                 540                 
Cys Lys Ala Asn Ile Gly Gly His Arg Ser Ser Cys Ser Phe Cys Lys
545                 550                 555                 560 
Asn Pro Arg Glu Val Thr Glu Ala Lys Gln Glu Leu Ile Thr Tyr Pro
                565                 570                 575     
Gln Pro Gln Lys Thr Ser Ile Pro Ala Pro Leu Glu Lys Gln Pro Asn
            580                 585                 590         
Gln Pro Leu Arg Pro Ala Asp Lys Glu Pro Glu Pro Arg Lys Arg Glu
        595                 600                 605             
Glu Gly Gln Glu Ser Arg Leu Gly His Gln Lys Arg Glu Ala Glu Arg
    610                 615                 620                 
Tyr Leu Pro Pro Ser Arg Arg Glu Gly Pro Thr Phe Arg Arg Asp Arg
625                 630                 635                 640 
Glu Lys Glu Ser Trp Ser Gly Glu Thr Arg Gln Asp Gly Glu Ser Lys
                645                 650                 655     
Thr Ile Met Leu Lys Arg Ile Tyr Arg Ser Thr Pro Pro Glu Val Ile
            660                 665                 670         
Val Glu Val Leu Glu Pro Tyr Val Arg Leu Thr Thr Ala Asn Val Arg
        675                 680                 685             
Ile Ile Lys Asn Arg Thr Gly Pro Met Gly His Thr Tyr Gly Phe Ile
    690                 695                 700                 
Asp Leu Asp Ser His Ala Glu Ala Leu Arg Val Val Lys Ile Leu Gln
705                 710                 715                 720 
Asn Leu Asp Pro Pro Phe Ser Ile Asp Gly Lys Met Val Ala Val Asn
                725                 730                 735     
Leu Ala Thr Gly Lys Arg Arg Asn Asp Ser Gly Asp His Ser Asp His
            740                 745                 750         
Met His Tyr Tyr Gln Gly Lys Lys Tyr Phe Arg Asp Arg Arg Gly Gly
        755                 760                 765             
Gly Arg Asn Ser Asp Trp Ser Ser Asp Thr Asn Arg Gln Gly Gln Gln
    770                 775                 780                 
Ser Ser Ser Asp Cys Tyr Ile Tyr Asp Ser Ala Thr Gly Tyr Tyr Tyr
785                 790                 795                 800 
Asp Pro Leu Ala Gly Thr Tyr Tyr Asp Pro Asn Thr Gln Gln Glu Val
                805                 810                 815     
Tyr Val Pro Gln Asp Pro Gly Leu Pro Glu Glu Glu Glu Ile Lys Glu
            820                 825                 830         
Lys Lys Pro Thr Ser Gln Gly Lys Ser Ser Ser Lys Lys Glu Met Ser
        835                 840                 845             
Lys Arg Asp Gly Lys Glu Lys Lys Asp Arg Gly Val Thr Arg Phe Gln
    850                 855                 860                 
Glu Asn Ala Ser Glu Gly Lys Ala Pro Ala Glu Asp Val Phe Lys Lys
865                 870                 875                 880 
Pro Leu Pro Pro Thr Val Lys Lys Glu Glu Ser Pro Pro Pro Pro Lys
                885                 890                 895     
Val Val Asn Pro Leu Ile Gly Leu Leu Gly Glu Tyr Gly Gly Asp Ser
            900                 905                 910         
Asp Tyr Glu Glu Glu Glu Glu Glu Glu Gln Thr Pro Pro Pro Gln Pro
        915                 920                 925             
Arg Thr Ala Gln Pro Gln Lys Arg Glu Glu Gln Thr Lys Lys Glu Asn
    930                 935                 940                 
Glu Glu Asp Lys Leu Thr Asp Trp Asn Lys Leu Ala Cys Leu Leu Cys
945                 950                 955                 960 
Arg Arg Gln Phe Pro Asn Lys Glu Val Leu Ile Lys His Gln Gln Leu
                965                 970                 975     
Ser Asp Leu His Lys Gln Asn Leu Glu Ile His Arg Lys Ile Lys Gln
            980                 985                 990         
Ser Glu Gln Glu Leu Ala Tyr Leu Glu Arg Arg Glu Arg Glu Gly Lys
        995                 1000                1005            
Phe Lys Gly Arg Gly Asn Asp Arg Arg Glu Lys Leu Gln Ser Phe Asp
    1010                1015                1020                
Ser Pro Glu Arg Lys Arg Ile Lys Tyr Ser Arg Glu Thr Asp Ser Asp
1025                1030                1035                1040
Arg Lys Leu Val Asp Lys Glu Asp Ile Asp Thr Ser Ser Lys Gly Gly
                1045                1050                1055    
Cys Val Gln Gln Ala Thr Gly Trp Arg Lys Gly Thr Gly Leu Gly Tyr
            1060                1065                1070        
Gly His Pro Gly Leu Ala Ser Ser Glu Glu Ala Glu Gly Arg Met Arg
        1075                1080                1085            
Gly Pro Ser Val Gly Ala Ser Gly Arg Thr Ser Lys Arg Gln Ser Asn
    1090                1095                1100                
Glu Thr Tyr Arg Asp Ala Val Arg Arg Val Met Phe Ala Arg Tyr Lys
1105                1110                1115                1120
Glu Leu Asp
            


<210> 8405
<211> 2342
<212> PRT
<213> Homo sapiens

<400> 8405
Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu
 1               5                  10                  15      
Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser
            20                  25                  30          
Pro Leu Gln Asp His Arg Gly Gly Asn Glu Arg Val Gln Glu Ser Asn
        35                  40                  45              
Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr
    50                  55                  60                  
Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser
65                  70                  75                  80  
Glu Met Glu Gly Cys Ser Ala Met Val Pro Ser Gln Leu Gln Leu Leu
                85                  90                  95      
Pro Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Glu Thr Glu
            100                 105                 110         
Thr Gly Glu Asn Leu Leu Leu Ile Gln Asn Lys Lys Leu Glu Asp Asn
        115                 120                 125             
Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu Leu Ser Ala Pro Ile His
    130                 135                 140                 
Thr Gln Met Gln Gln Lys Glu Phe Ser Ile Ile Glu His Thr Arg Glu
145                 150                 155                 160 
Arg Lys His Ala Asn Asp Gln Thr Val Ile Phe Ser Asp Glu Asn Gln
                165                 170                 175     
Met Asp Leu Thr Ser Ser His Thr Val Met Ile Thr Lys Gly Leu Leu
            180                 185                 190         
Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys Ile Asp Thr Thr Ser Phe
        195                 200                 205             
Leu Ala Asn Leu Lys Leu His Thr Glu Asp Ser Arg Met Lys Lys Glu
    210                 215                 220                 
Val Asn Phe Ser Val Asp Gln Asn Thr Ser Ser Glu Asn Lys Ile Asp
225                 230                 235                 240 
Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr Gly Lys Cys Ser Ala Phe
                245                 250                 255     
Pro Asp Val Pro Asp Lys Glu Asn Phe Glu Ile Pro Ile Tyr Ser Lys
            260                 265                 270         
Glu Pro Asn Ser Ala Ser Ser Thr His Gln Met His Val Ser Leu Lys
        275                 280                 285             
Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg Leu Phe Arg Glu Lys Asp
    290                 295                 300                 
Asp Gly Met Asn Phe Thr Gln Cys His Thr Ala Asn Ile Gln Thr Leu
305                 310                 315                 320 
Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg Glu Ser Lys Gly Asn Asp
                325                 330                 335     
Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp Leu Thr Phe Asn His Thr
            340                 345                 350         
Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe Ser Glu Ile Glu Asn Gln
        355                 360                 365             
Thr Gln Asn Ala Met Asp Val Thr Thr Gly Tyr Gly Thr Lys Ala Ser
    370                 375                 380                 
Gly Asn Lys Thr Val Phe Lys Ser Lys Gln Asn Thr Ala Phe Gln Asp
385                 390                 395                 400 
Leu Ser Ile Asn Ser Ala Asp Lys Ile His Ile Thr Arg Ser His Ile
                405                 410                 415     
Met Gly Ala Glu Thr His Ile Val Ser Gln Thr Cys Asn Gln Asp Ala
            420                 425                 430         
Arg Ile Leu Ala Met Thr Pro Glu Ser Ile Tyr Ser Asn Pro Ser Ile
        435                 440                 445             
Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser Cys Asn Asp Ala Met Glu
    450                 455                 460                 
Met Thr Lys Cys Leu Ser Asn Met Arg Glu Glu Lys Asn Leu Leu Lys
465                 470                 475                 480 
His Asp Ser Asn Tyr Ala Lys Met Tyr Cys Asn Pro Asp Ala Met Ser
                485                 490                 495     
Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly Glu Glu Asn Met Asp Ile
            500                 505                 510         
Thr Lys Ser His Thr Val Ala Ile Asp Asn Gln Ile Phe Lys Gln Asp
        515                 520                 525             
Gln Ser Asn Val Gln Ile Ala Ala Ala Pro Thr Pro Glu Lys Glu Met
    530                 535                 540                 
Met Leu Gln Asn Leu Met Thr Thr Ser Glu Asp Gly Lys Met Asn Val
545                 550                 555                 560 
Asn Cys Asn Ser Val Pro His Val Ser Lys Glu Arg Ile Gln Gln Ser
                565                 570                 575     
Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr Asp Arg Lys Thr Glu Leu
            580                 585                 590         
Leu Ser Gly Glu Asn Thr Asp Leu Thr Glu Ser His Thr Ser Asn Leu
        595                 600                 605             
Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn Leu Ala Pro Glu Ser Thr
    610                 615                 620                 
Ser Glu Ser His Ser Gln Ser Lys Ser Ser Ser Asp Glu Cys Glu Glu
625                 630                 635                 640 
Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln Arg Ser Asp Ile Ile Ala
                645                 650                 655     
Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys Asp Lys Asp Trp Val Leu
            660                 665                 670         
Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser Pro Gln Ser Ala Asp Cys
        675                 680                 685             
Asn Gln Glu Ile Ala Thr Ser His Asn Ile Val Tyr Cys Gly Gly Val
    690                 695                 700                 
Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr Val Ser Trp Glu Gln Ser
705                 710                 715                 720 
Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser Ser Gly Gln Phe Ser Met
                725                 730                 735     
Lys Asn His Asp Thr Ala Ile Ser Ser His Thr Val Lys Ser Val Leu
            740                 745                 750         
Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu Arg Lys Ser Leu Ser Asn
        755                 760                 765             
Pro Thr Pro Asp Tyr Cys His Asp Lys Met Ile Ile Cys Ser Glu Glu
    770                 775                 780                 
Glu Gln Asn Met Asp Leu Thr Lys Ser His Thr Val Val Ile Gly Phe
785                 790                 795                 800 
Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys Thr Asn Leu Glu His Thr
                805                 810                 815     
Thr Gly Gln Leu Thr Thr Met Asn Arg Gln Ile Ala Val Lys Val Glu
            820                 825                 830         
Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser Gly Val Leu Lys Ser Asn
        835                 840                 845             
Cys Ile Met Asp Val Leu Glu Asp Glu Ser Val Gln Lys Pro Lys Phe
    850                 855                 860                 
Pro Lys Glu Lys Gln Asn Val Lys Ile Trp Gly Arg Lys Ser Val Gly
865                 870                 875                 880 
Gly Pro Lys Ile Asp Lys Thr Ile Val Phe Ser Glu Asp Asp Lys Asn
                885                 890                 895     
Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile Glu Ile Asn His Arg Pro
            900                 905                 910         
Leu Leu Glu Lys Arg Asp Cys His Leu Val Pro Leu Ala Gly Thr Ser
        915                 920                 925             
Glu Thr Ile Leu Tyr Thr Cys Gly Gln Asp Asp Met Glu Ile Thr Arg
    930                 935                 940                 
Ser His Thr Thr Ala Leu Glu Cys Lys Thr Val Ser Pro Asp Glu Ile
945                 950                 955                 960 
Thr Thr Arg Pro Met Asp Lys Thr Val Val Phe Val Asp Asn His Val
                965                 970                 975     
Glu Leu Glu Met Thr Glu Ser His Thr Val Phe Ile Asp Tyr Gln Glu
            980                 985                 990         
Lys Glu Arg Thr Asp Arg Pro Asn Phe Glu Leu Ser Gln Arg Lys Ser
        995                 1000                1005            
Leu Gly Thr Pro Thr Val Ile Cys Thr Pro Thr Glu Glu Ser Val Phe
    1010                1015                1020                
Phe Pro Gly Asn Gly Glu Ser Asp Arg Leu Val Ala Asn Asp Ser Gln
1025                1030                1035                1040
Leu Thr Pro Leu Glu Glu Trp Ser Asn Asn Arg Gly Pro Val Glu Val
                1045                1050                1055    
Ala Asp Asn Met Glu Leu Ser Lys Ser Ala Thr Cys Lys Asn Ile Lys
            1060                1065                1070        
Asp Val Gln Ser Pro Gly Phe Leu Asn Glu Pro Leu Ser Ser Lys Ser
        1075                1080                1085            
Gln Arg Arg Lys Ser Leu Lys Leu Lys Asn Asp Lys Thr Ile Val Phe
    1090                1095                1100                
Ser Glu Asn His Lys Asn Asp Met Asp Ile Thr Gln Ser Cys Met Val
1105                1110                1115                1120
Glu Ile Asp Asn Glu Ser Ala Leu Glu Asp Lys Glu Asp Phe His Leu
                1125                1130                1135    
Ala Gly Ala Ser Lys Thr Ile Leu Tyr Ser Cys Gly Gln Asp Asp Met
            1140                1145                1150        
Glu Ile Thr Arg Ser His Thr Thr Ala Leu Glu Cys Lys Thr Leu Leu
        1155                1160                1165            
Pro Asn Glu Ile Ala Ile Arg Pro Met Asp Lys Thr Val Leu Phe Thr
    1170                1175                1180                
Asp Asn Tyr Ser Asp Leu Glu Val Thr Asp Ser His Thr Val Phe Ile
1185                1190                1195                1200
Asp Cys Gln Ala Thr Glu Lys Ile Leu Glu Glu Asn Pro Lys Phe Gly
                1205                1210                1215    
Ile Gly Lys Gly Lys Asn Leu Gly Val Ser Phe Pro Lys Asp Asn Ser
            1220                1225                1230        
Cys Val Gln Glu Ile Ala Glu Lys Gln Ala Leu Ala Val Gly Asn Lys
        1235                1240                1245            
Ile Val Leu His Thr Glu Gln Lys Gln Gln Leu Phe Ala Ala Thr Asn
    1250                1255                1260                
Arg Thr Thr Asn Glu Ile Ile Lys Phe His Ser Ala Ala Met Asp Glu
1265                1270                1275                1280
Lys Val Ile Gly Lys Val Val Asp Gln Ala Cys Thr Leu Glu Lys Ala
                1285                1290                1295    
Gln Val Glu Ser Cys Gln Leu Asn Asn Arg Asp Arg Arg Asn Val Asp
            1300                1305                1310        
Phe Thr Ser Ser His Ala Thr Ala Val Cys Gly Ser Ser Asp Asn Tyr
        1315                1320                1325            
Ser Cys Leu Pro Asn Val Ile Ser Cys Thr Asp Asn Leu Glu Gly Ser
    1330                1335                1340                
Ala Met Leu Leu Cys Asp Lys Asp Glu Glu Lys Ala Asn Tyr Cys Pro
1345                1350                1355                1360
Val Gln Asn Asp Leu Ala Tyr Ala Asn Asp Phe Ala Ser Glu Tyr Tyr
                1365                1370                1375    
Leu Glu Ser Glu Gly Gln Pro Leu Ser Ala Pro Cys Pro Leu Leu Glu
            1380                1385                1390        
Lys Glu Glu Val Ile Gln Thr Ser Thr Lys Gly Gln Leu Asp Cys Val
        1395                1400                1405            
Ile Thr Leu His Lys Asp Gln Asp Leu Ile Lys Asp Pro Arg Asn Leu
    1410                1415                1420                
Leu Ala Asn Gln Thr Leu Val Tyr Ser Gln Asp Leu Gly Glu Met Thr
1425                1430                1435                1440
Lys Leu Asn Ser Lys Arg Val Ser Phe Lys Leu Pro Lys Asp Gln Met
                1445                1450                1455    
Lys Val Tyr Val Asp Asp Ile Tyr Val Ile Pro Gln Pro His Phe Ser
            1460                1465                1470        
Thr Asp Gln Pro Pro Leu Pro Lys Lys Gly Gln Ser Ser Ile Asn Lys
        1475                1480                1485            
Glu Glu Val Ile Leu Ser Lys Ala Gly Asn Lys Ser Leu Asn Ile Ile
    1490                1495                1500                
Glu Asn Ser Ser Ala Pro Ile Cys Glu Asn Lys Pro Lys Ile Leu Asn
1505                1510                1515                1520
Ser Glu Glu Trp Phe Ala Ala Ala Cys Lys Lys Glu Leu Lys Glu Asn
                1525                1530                1535    
Ile Gln Thr Thr Asn Tyr Asn Thr Ala Leu Asp Phe His Ser Asn Ser
            1540                1545                1550        
Asp Val Thr Lys Gln Val Ile Gln Thr His Val Asn Ala Gly Glu Ala
        1555                1560                1565            
Pro Asp Pro Val Ile Thr Ser Asn Val Pro Cys Phe His Ser Ile Lys
    1570                1575                1580                
Pro Asn Leu Asn Asn Leu Asn Gly Lys Thr Gly Glu Phe Leu Ala Phe
1585                1590                1595                1600
Gln Thr Val His Leu Pro Pro Leu Pro Glu Gln Leu Leu Glu Leu Gly
                1605                1610                1615    
Asn Lys Ala His Asn Asp Met His Ile Val Gln Ala Thr Glu Ile His
            1620                1625                1630        
Asn Ile Asn Ile Ile Ser Ser Asn Ala Lys Asp Ser Arg Asp Glu Glu
        1635                1640                1645            
Asn Lys Lys Ser His Asn Gly Ala Glu Thr Thr Ser Leu Pro Pro Lys
    1650                1655                1660                
Thr Val Phe Lys Asp Lys Val Arg Arg Cys Ser Leu Gly Ile Phe Leu
1665                1670                1675                1680
Pro Arg Leu Pro Asn Lys Arg Asn Cys Ser Val Thr Gly Ile Asp Asp
                1685                1690                1695    
Leu Glu Gln Ile Pro Ala Asp Thr Thr Asp Ile Asn His Leu Glu Thr
            1700                1705                1710        
Gln Pro Val Ser Ser Lys Asp Ser Gly Ile Gly Ser Val Ala Gly Lys
        1715                1720                1725            
Leu Asn Leu Ser Pro Ser Gln Tyr Ile Asn Glu Glu Asn Leu Pro Val
    1730                1735                1740                
Tyr Pro Asp Glu Ile Asn Ser Ser Asp Ser Ile Asn Ile Glu Thr Glu
1745                1750                1755                1760
Glu Lys Ala Leu Ile Glu Thr Tyr Gln Lys Glu Ile Ser Pro Tyr Glu
                1765                1770                1775    
Asn Lys Met Gly Lys Thr Cys Asn Ser Gln Lys Arg Thr Trp Val Gln
            1780                1785                1790        
Glu Glu Glu Asp Ile His Lys Glu Lys Lys Ile Arg Lys Asn Glu Ile
        1795                1800                1805            
Lys Phe Ser Asp Thr Thr Gln Asp Arg Glu Ile Phe Asp His His Thr
    1810                1815                1820                
Glu Glu Asp Ile Asp Lys Ser Ala Asn Ser Val Leu Ile Lys Asn Leu
1825                1830                1835                1840
Ser Arg Thr Pro Ser Ser Cys Ser Ser Ser Leu Asp Ser Ile Lys Ala
                1845                1850                1855    
Asp Gly Thr Ser Leu Asp Phe Ser Thr Tyr Arg Ser Ser Gln Met Glu
            1860                1865                1870        
Ser Gln Phe Leu Arg Asp Thr Ile Cys Glu Glu Ser Leu Arg Glu Lys
        1875                1880                1885            
Leu Gln Asp Gly Arg Ile Thr Ile Arg Glu Phe Phe Ile Leu Leu Gln
    1890                1895                1900                
Val His Ile Leu Ile Gln Lys Pro Arg Gln Ser Asn Leu Pro Gly Asn
1905                1910                1915                1920
Phe Thr Val Asn Thr Pro Pro Thr Pro Glu Asp Leu Met Leu Ser Gln
                1925                1930                1935    
Tyr Val Tyr Arg Pro Lys Ile Gln Ile Tyr Arg Glu Asp Cys Glu Ala
            1940                1945                1950        
Arg Arg Gln Lys Ile Glu Glu Leu Lys Leu Ser Ala Ser Asn Gln Asp
        1955                1960                1965            
Lys Leu Leu Val Asp Ile Asn Lys Asn Leu Trp Glu Lys Met Arg His
    1970                1975                1980                
Cys Ser Asp Lys Glu Leu Lys Ala Phe Gly Ile Tyr Leu Asn Lys Ile
1985                1990                1995                2000
Lys Ser Cys Phe Thr Lys Met Thr Lys Val Phe Thr His Gln Gly Lys
                2005                2010                2015    
Val Ala Leu Tyr Gly Lys Leu Val Gln Ser Ala Gln Asn Glu Arg Glu
            2020                2025                2030        
Lys Leu Gln Ile Lys Ile Asp Glu Met Asp Lys Ile Leu Lys Lys Ile
        2035                2040                2045            
Asp Asn Cys Leu Thr Glu Met Glu Thr Glu Thr Lys Asn Leu Glu Asp
    2050                2055                2060                
Glu Glu Lys Asn Asn Pro Val Glu Glu Trp Asp Ser Glu Met Arg Ala
2065                2070                2075                2080
Ala Glu Lys Glu Leu Glu Gln Leu Lys Thr Glu Glu Glu Glu Leu Gln
                2085                2090                2095    
Arg Asn Leu Leu Glu Leu Glu Val Gln Lys Glu Gln Thr Leu Ala Gln
            2100                2105                2110        
Ile Asp Phe Met Gln Lys Gln Arg Asn Arg Thr Glu Glu Leu Leu Asp
        2115                2120                2125            
Gln Leu Ser Leu Ser Glu Trp Asp Val Val Glu Trp Ser Asp Asp Gln
    2130                2135                2140                
Ala Val Phe Thr Phe Val Tyr Asp Thr Ile Gln Leu Thr Ile Thr Phe
2145                2150                2155                2160
Glu Glu Ser Val Val Gly Phe Pro Phe Leu Asp Lys Arg Tyr Arg Lys
                2165                2170                2175    
Ile Val Asp Val Asn Phe Gln Ser Leu Leu Asp Glu Asp Gln Ala Pro
            2180                2185                2190        
Pro Ser Ser Leu Leu Val His Lys Leu Ile Phe Gln Tyr Val Glu Glu
        2195                2200                2205            
Lys Glu Ser Trp Lys Lys Thr Cys Thr Thr Gln His Gln Leu Pro Lys
    2210                2215                2220                
Met Leu Glu Glu Phe Ser Leu Val Val His His Cys Arg Leu Leu Gly
2225                2230                2235                2240
Glu Glu Ile Glu Tyr Leu Lys Arg Trp Gly Pro Asn Tyr Asn Leu Met
                2245                2250                2255    
Asn Ile Asp Ile Asn Asn Asn Glu Leu Arg Leu Leu Phe Ser Ser Ser
            2260                2265                2270        
Ala Ala Phe Ala Lys Phe Glu Ile Thr Leu Phe Leu Ser Ala Tyr Tyr
        2275                2280                2285            
Pro Ser Val Pro Leu Pro Ser Thr Ile Gln Asn His Val Gly Asn Thr
    2290                2295                2300                
Ser Gln Asp Asp Ile Ala Thr Ile Leu Ser Lys Val Pro Leu Glu Asn
2305                2310                2315                2320
Asn Tyr Leu Lys Asn Val Val Lys Gln Ile Tyr Gln Asp Leu Phe Gln
                2325                2330                2335    
Asp Cys His Phe Tyr His
            2340        


<210> 8406
<211> 2316
<212> PRT
<213> Homo sapiens

<400> 8406
Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu
 1               5                  10                  15      
Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser
            20                  25                  30          
Pro Leu Gln Asp Leu Arg Gly Gly Asn Glu Arg Val Gln Glu Ser Asn
        35                  40                  45              
Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr
    50                  55                  60                  
Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser
65                  70                  75                  80  
Glu Met Glu Glu Thr Glu Thr Gly Glu Asn Leu Leu Leu Ile Gln Asn
                85                  90                  95      
Lys Lys Leu Glu Asp Asn Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu
            100                 105                 110         
Leu Ser Ala Pro Ile His Thr Gln Met Gln Gln Lys Glu Phe Ser Ile
        115                 120                 125             
Ile Glu His Thr Arg Glu Arg Lys His Ala Asn Asp Gln Thr Val Ile
    130                 135                 140                 
Phe Ser Asp Glu Asn Gln Met Asp Leu Thr Ser Ser His Thr Val Met
145                 150                 155                 160 
Ile Thr Lys Gly Leu Leu Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys
                165                 170                 175     
Ile Asp Thr Thr Ser Phe Leu Ala Asn Leu Lys Leu His Thr Glu Asp
            180                 185                 190         
Ser Arg Met Lys Lys Glu Val Asn Phe Ser Val Asp Gln Asn Thr Ser
        195                 200                 205             
Ser Glu Asn Lys Ile Asp Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr
    210                 215                 220                 
Gly Lys Cys Ser Ala Phe Pro Asp Val Pro Asp Lys Glu Asn Phe Glu
225                 230                 235                 240 
Ile Pro Ile Tyr Ser Lys Glu Pro Asn Ser Ala Ser Ser Thr His Gln
                245                 250                 255     
Met His Val Ser Leu Lys Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg
            260                 265                 270         
Leu Phe Arg Glu Lys Asp Asp Gly Met Asn Phe Thr Gln Cys His Thr
        275                 280                 285             
Ala Asn Ile Gln Thr Leu Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg
    290                 295                 300                 
Glu Ser Lys Gly Asn Asp Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp
305                 310                 315                 320 
Leu Thr Phe Asn His Thr Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe
                325                 330                 335     
Ser Glu Ile Glu Asn Gln Thr Gln Asn Ala Met Asp Val Thr Thr Gly
            340                 345                 350         
Tyr Gly Thr Lys Ala Ser Gly Asn Lys Thr Val Phe Lys Ser Lys Gln
        355                 360                 365             
Asn Thr Ala Phe Gln Asp Leu Ser Ile Asn Ser Ala Asp Lys Ile His
    370                 375                 380                 
Ile Thr Arg Ser His Ile Met Gly Ala Glu Thr His Ile Val Ser Gln
385                 390                 395                 400 
Thr Cys Asn Gln Asp Ala Arg Ile Leu Ala Met Thr Pro Glu Ser Ile
                405                 410                 415     
Tyr Ser Asn Pro Ser Ile Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser
            420                 425                 430         
Cys Asn Asp Ala Met Glu Met Thr Lys Cys Leu Ser Asn Met Arg Glu
        435                 440                 445             
Glu Lys Asn Leu Leu Lys His Asp Ser Asn Tyr Ser Lys Met Tyr Cys
    450                 455                 460                 
Asn Pro Asp Ala Met Ser Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly
465                 470                 475                 480 
Glu Glu Asn Met Asp Ile Thr Lys Ser His Thr Val Ala Ile Asp Asn
                485                 490                 495     
Gln Ile Phe Lys Gln Asp Gln Ser Asn Val Gln Ile Ala Ala Ala Pro
            500                 505                 510         
Thr Pro Glu Lys Glu Met Met Leu Gln Asn Leu Met Thr Thr Ser Glu
        515                 520                 525             
Asp Gly Lys Met Asn Val Asn Cys Asn Ser Val Pro His Val Ser Lys
    530                 535                 540                 
Glu Arg Ile Gln Gln Ser Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr
545                 550                 555                 560 
Asp Arg Lys Thr Glu Leu Leu Ser Gly Glu Asn Thr Asp Leu Thr Glu
                565                 570                 575     
Ser His Thr Ser Asn Leu Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn
            580                 585                 590         
Leu Ala Pro Glu Ser Thr Ser Glu Ser His Ser Gln Ser Lys Ser Ser
        595                 600                 605             
Ser Asp Glu Cys Glu Glu Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln
    610                 615                 620                 
Arg Ser Asp Ile Ile Ala Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys
625                 630                 635                 640 
Asp Lys Asp Trp Val Leu Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser
                645                 650                 655     
Pro Gln Ser Ala Asp Cys Asn Gln Glu Ile Ala Thr Ser His Asn Ile
            660                 665                 670         
Val Tyr Cys Gly Gly Val Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr
        675                 680                 685             
Val Ser Trp Glu Gln Ser Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser
    690                 695                 700                 
Ser Gly Gln Phe Ser Met Lys Asn His Asp Thr Ala Ile Ser Ser His
705                 710                 715                 720 
Thr Val Lys Ser Val Leu Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu
                725                 730                 735     
Arg Lys Ser Leu Ser Asn Pro Thr Pro Asp Tyr Cys His Asp Lys Met
            740                 745                 750         
Ile Ile Cys Ser Glu Glu Glu Gln Asn Met Asp Leu Thr Lys Ser His
        755                 760                 765             
Thr Val Val Ile Gly Phe Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys
    770                 775                 780                 
Thr Asn Leu Glu His Thr Thr Gly Gln Leu Thr Thr Met Asn Arg Gln
785                 790                 795                 800 
Ile Ala Val Lys Val Glu Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser
                805                 810                 815     
Gly Val Leu Lys Ser Asn Cys Ile Met Asp Val Leu Glu Asp Glu Ser
            820                 825                 830         
Val Gln Lys Pro Lys Phe Pro Lys Glu Lys Gln Asn Val Lys Ile Trp
        835                 840                 845             
Gly Arg Lys Ser Val Gly Gly Pro Lys Ile Asp Lys Thr Ile Val Phe
    850                 855                 860                 
Ser Glu Asp Asp Lys Asn Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile
865                 870                 875                 880 
Glu Ile Asn His Arg Pro Leu Leu Glu Lys Arg Asp Cys His Leu Val
                885                 890                 895     
Pro Leu Ala Gly Thr Ser Glu Thr Ile Leu Tyr Thr Cys Gly Gln Asp
            900                 905                 910         
Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu Glu Cys Lys Thr
        915                 920                 925             
Val Ser Pro Asp Glu Ile Thr Thr Arg Pro Met Asp Lys Thr Val Val
    930                 935                 940                 
Phe Val Asp Asn His Val Glu Leu Glu Met Thr Glu Ser His Thr Val
945                 950                 955                 960 
Phe Ile Asp Tyr Gln Glu Lys Glu Arg Thr Asp Arg Pro Asn Phe Glu
                965                 970                 975     
Leu Ser Gln Arg Lys Ser Leu Gly Thr Pro Thr Val Ile Cys Thr Pro
            980                 985                 990         
Thr Glu Glu Ser Val Phe Phe Pro Gly Asn Gly Glu Ser Asp Arg Leu
        995                 1000                1005            
Val Ala Asn Asp Ser Gln Leu Thr Pro Leu Glu Glu Trp Ser Asn Asn
    1010                1015                1020                
Arg Gly Pro Val Glu Val Ala Asp Asn Met Glu Leu Ser Lys Ser Ala
1025                1030                1035                1040
Thr Cys Lys Asn Ile Lys Asp Val Gln Ser Pro Gly Phe Leu Asn Glu
                1045                1050                1055    
Pro Leu Ser Ser Lys Ser Gln Arg Arg Lys Ser Leu Lys Leu Lys Asn
            1060                1065                1070        
Asp Lys Thr Ile Val Phe Ser Glu Asn His Lys Asn Asp Met Asp Ile
        1075                1080                1085            
Thr Gln Ser Cys Met Val Glu Ile Asp Asn Glu Ser Ala Leu Glu Asp
    1090                1095                1100                
Lys Glu Asp Phe His Leu Ala Gly Ala Ser Lys Thr Ile Leu Tyr Ser
1105                1110                1115                1120
Cys Gly Gln Asp Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu
                1125                1130                1135    
Glu Cys Lys Thr Leu Leu Pro Asn Glu Ile Ala Ile Arg Pro Met Asp
            1140                1145                1150        
Lys Thr Val Leu Phe Thr Asp Asn Tyr Ser Asp Leu Glu Val Thr Asp
        1155                1160                1165            
Ser His Thr Val Phe Ile Asp Cys Gln Ala Thr Glu Lys Ile Leu Glu
    1170                1175                1180                
Glu Asn Pro Lys Phe Gly Ile Gly Lys Gly Lys Asn Leu Gly Val Ser
1185                1190                1195                1200
Phe Pro Lys Asp Asn Ser Cys Val Gln Glu Ile Ala Glu Lys Gln Ala
                1205                1210                1215    
Leu Ala Val Gly Asn Lys Ile Val Leu His Thr Glu Gln Lys Gln Gln
            1220                1225                1230        
Leu Phe Ala Ala Thr Asn Arg Thr Thr Asn Glu Ile Ile Lys Phe His
        1235                1240                1245            
Ser Ala Ala Met Asp Glu Lys Val Ile Gly Lys Val Val Asp Gln Ala
    1250                1255                1260                
Cys Thr Leu Glu Lys Ala Gln Val Glu Ser Cys Gln Leu Asn Asn Arg
1265                1270                1275                1280
Asp Arg Arg Asn Val Asp Phe Thr Ser Ser His Ala Thr Ala Val Cys
                1285                1290                1295    
Gly Ser Ser Asp Asn Tyr Ser Cys Leu Pro Asn Val Ile Ser Cys Thr
            1300                1305                1310        
Asp Asn Leu Glu Gly Ser Ala Met Leu Leu Cys Asp Lys Asp Glu Glu
        1315                1320                1325            
Lys Ala Asn Tyr Cys Pro Val Gln Asn Asp Leu Ala Tyr Ala Asn Asp
    1330                1335                1340                
Phe Ala Ser Glu Tyr Tyr Leu Glu Ser Glu Gly Gln Pro Leu Ser Ala
1345                1350                1355                1360
Pro Cys Pro Leu Leu Glu Lys Glu Glu Val Ile Gln Thr Ser Thr Lys
                1365                1370                1375    
Gly Gln Leu Asp Cys Val Ile Thr Leu His Lys Asp Gln Asp Leu Ile
            1380                1385                1390        
Lys Asp Pro Arg Asn Leu Leu Ala Asn Gln Thr Leu Val Tyr Ser Gln
        1395                1400                1405            
Asp Leu Gly Glu Met Thr Lys Leu Asn Ser Lys Arg Val Ser Phe Lys
    1410                1415                1420                
Leu Pro Lys Asp Gln Met Lys Val Tyr Val Asp Asp Ile Tyr Val Ile
1425                1430                1435                1440
Pro Gln Pro His Phe Ser Thr Asp Gln Pro Pro Leu Pro Lys Lys Gly
                1445                1450                1455    
Gln Ser Ser Ile Asn Lys Glu Glu Val Ile Leu Ser Lys Ala Gly Asn
            1460                1465                1470        
Lys Ser Leu Asn Ile Ile Glu Asn Ser Ser Ala Pro Ile Cys Glu Asn
        1475                1480                1485            
Lys Pro Lys Ile Leu Asn Ser Glu Glu Trp Phe Ala Ala Ala Cys Lys
    1490                1495                1500                
Lys Glu Leu Lys Glu Asn Ile Gln Thr Thr Asn Tyr Asn Thr Ala Leu
1505                1510                1515                1520
Asp Phe His Ser Asn Ser Asp Val Thr Lys Gln Val Ile Gln Thr His
                1525                1530                1535    
Val Asn Ala Gly Glu Ala Pro Asp Pro Val Ile Thr Ser Asn Val Pro
            1540                1545                1550        
Cys Phe His Ser Ile Lys Pro Asn Leu Asn Asn Leu Asn Gly Lys Thr
        1555                1560                1565            
Gly Glu Phe Leu Ala Phe Gln Thr Val His Leu Pro Pro Leu Pro Glu
    1570                1575                1580                
Gln Leu Leu Glu Leu Gly Asn Lys Ala His Asn Asp Met His Ile Val
1585                1590                1595                1600
Gln Ala Thr Glu Ile His Asn Ile Asn Ile Ile Ser Ser Asn Ala Lys
                1605                1610                1615    
Asp Ser Arg Asp Glu Glu Asn Lys Lys Ser His Asn Gly Ala Glu Thr
            1620                1625                1630        
Thr Ser Leu Pro Pro Lys Thr Val Phe Lys Asp Lys Val Arg Arg Cys
        1635                1640                1645            
Ser Leu Gly Ile Phe Leu Pro Arg Leu Pro Asn Lys Arg Asn Cys Ser
    1650                1655                1660                
Val Thr Gly Ile Asp Asp Leu Glu Gln Ile Pro Ala Asp Thr Thr Asp
1665                1670                1675                1680
Ile Asn His Leu Glu Thr Gln Pro Val Ser Ser Lys Asp Ser Gly Ile
                1685                1690                1695    
Gly Ser Val Ala Gly Lys Leu Asn Leu Ser Pro Ser Gln Tyr Ile Asn
            1700                1705                1710        
Glu Glu Asn Leu Pro Val Tyr Pro Asp Glu Ile Asn Ser Ser Asp Ser
        1715                1720                1725            
Ile Asn Ile Glu Thr Glu Glu Lys Ala Leu Ile Glu Thr Tyr Gln Lys
    1730                1735                1740                
Glu Ile Ser Pro Tyr Glu Asn Lys Met Gly Lys Thr Cys Asn Ser Gln
1745                1750                1755                1760
Lys Arg Thr Trp Val Gln Glu Glu Glu Asp Ile His Lys Glu Lys Lys
                1765                1770                1775    
Ile Arg Lys Asn Glu Ile Lys Phe Ser Asp Thr Thr Gln Asp Arg Glu
            1780                1785                1790        
Ile Phe Asp His His Thr Glu Glu Asp Ile Asp Lys Ser Ala Asn Ser
        1795                1800                1805            
Val Leu Ile Lys Asn Leu Ser Arg Thr Pro Ser Ser Cys Ser Ser Ser
    1810                1815                1820                
Leu Asp Ser Ile Lys Ala Asp Gly Thr Ser Leu Asp Phe Ser Thr Tyr
1825                1830                1835                1840
Arg Ser Ser Gln Met Glu Ser Gln Phe Leu Arg Asp Thr Ile Cys Glu
                1845                1850                1855    
Glu Ser Leu Arg Glu Lys Leu Gln Asp Gly Arg Ile Thr Ile Arg Glu
            1860                1865                1870        
Phe Phe Ile Leu Leu Gln Val His Ile Leu Ile Gln Lys Pro Arg Gln
        1875                1880                1885            
Ser Asn Leu Pro Gly Asn Phe Thr Val Asn Thr Pro Pro Thr Pro Glu
    1890                1895                1900                
Asp Leu Met Leu Ser Gln Tyr Val Tyr Arg Pro Lys Ile Gln Ile Tyr
1905                1910                1915                1920
Arg Glu Asp Cys Glu Ala Arg Arg Gln Lys Ile Glu Glu Leu Lys Leu
                1925                1930                1935    
Ser Ala Ser Asn Gln Asp Lys Leu Leu Val Asp Ile Asn Lys Asn Leu
            1940                1945                1950        
Trp Glu Lys Met Arg His Cys Ser Asp Lys Glu Leu Lys Ala Phe Gly
        1955                1960                1965            
Ile Tyr Leu Asn Lys Ile Lys Ser Cys Phe Thr Lys Met Thr Lys Val
    1970                1975                1980                
Phe Thr His Gln Gly Lys Val Ala Leu Tyr Gly Lys Leu Val Gln Ser
1985                1990                1995                2000
Ala Gln Asn Glu Arg Glu Lys Leu Gln Ile Lys Ile Asp Glu Met Asp
                2005                2010                2015    
Lys Ile Leu Lys Lys Ile Asp Asn Cys Leu Thr Glu Met Glu Thr Glu
            2020                2025                2030        
Thr Lys Asn Leu Glu Asp Glu Glu Lys Asn Asn Pro Val Glu Glu Trp
        2035                2040                2045            
Asp Ser Glu Met Arg Ala Ala Glu Lys Glu Leu Glu Gln Leu Lys Thr
    2050                2055                2060                
Glu Glu Glu Glu Leu Gln Arg Asn Leu Leu Glu Leu Glu Val Gln Lys
2065                2070                2075                2080
Glu Gln Thr Leu Ala Gln Ile Asp Phe Met Gln Lys Gln Arg Asn Arg
                2085                2090                2095    
Thr Glu Glu Leu Leu Asp Gln Leu Ser Leu Ser Glu Trp Asp Val Val
            2100                2105                2110        
Glu Trp Ser Asp Asp Gln Ala Val Phe Thr Phe Val Tyr Asp Thr Ile
        2115                2120                2125            
Gln Leu Thr Ile Thr Phe Glu Glu Ser Val Val Gly Phe Pro Phe Leu
    2130                2135                2140                
Asp Lys Arg Tyr Arg Lys Ile Val Asp Val Asn Phe Gln Ser Leu Leu
2145                2150                2155                2160
Asp Glu Asp Gln Ala Pro Pro Ser Ser Leu Leu Val His Lys Leu Ile
                2165                2170                2175    
Phe Gln Tyr Val Glu Glu Lys Glu Ser Trp Lys Lys Thr Cys Thr Thr
            2180                2185                2190        
Gln His Gln Leu Pro Lys Met Leu Glu Glu Phe Ser Leu Val Val His
        2195                2200                2205            
His Cys Arg Leu Leu Gly Glu Glu Ile Glu Tyr Leu Lys Arg Trp Gly
    2210                2215                2220                
Pro Asn Tyr Asn Leu Met Asn Ile Asp Ile Asn Asn Asn Glu Leu Arg
2225                2230                2235                2240
Leu Leu Phe Ser Ser Ser Ala Ala Phe Ala Lys Phe Glu Ile Thr Leu
                2245                2250                2255    
Phe Leu Ser Ala Tyr Tyr Pro Ser Val Pro Leu Pro Ser Thr Ile Gln
            2260                2265                2270        
Asn His Val Gly Asn Thr Ser Gln Asp Asp Ile Ala Thr Ile Leu Ser
        2275                2280                2285            
Lys Val Pro Leu Glu Asn Asn Tyr Leu Lys Asn Val Val Lys Gln Ile
    2290                2295                2300                
Tyr Gln Asp Leu Phe Gln Asp Cys His Phe Tyr His
2305                2310                2315    


<210> 8407
<211> 1746
<212> PRT
<213> Homo sapiens

<400> 8407
Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu
 1               5                  10                  15      
Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser
            20                  25                  30          
Pro Leu Gln Asp Leu Arg Gly Gly Asn Glu Thr Val Gln Glu Ser Asn
        35                  40                  45              
Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr
    50                  55                  60                  
Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser
65                  70                  75                  80  
Glu Met Glu Glu Thr Glu Ala Gly Glu Asn Leu Leu Leu Ile Gln Asn
                85                  90                  95      
Lys Lys Leu Glu Asp Asn Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu
            100                 105                 110         
Leu Ser Ala Pro Ile His Thr Gln Met Gln Gln Lys Glu Phe Ser Ile
        115                 120                 125             
Ile Glu His Thr Arg Glu Arg Lys His Ala Asn Asp Gln Thr Val Ile
    130                 135                 140                 
Phe Ser Asp Glu Asn Gln Met Asp Leu Thr Ser Ser His Thr Val Met
145                 150                 155                 160 
Ile Thr Lys Gly Leu Leu Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys
                165                 170                 175     
Ile Asp Thr Thr Ser Phe Leu Ala Asn Leu Lys Leu His Thr Glu Asp
            180                 185                 190         
Ser Arg Met Lys Lys Glu Val Asn Phe Ser Val Asp Gln Asn Thr Ser
        195                 200                 205             
Ser Glu Asn Lys Ile Asp Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr
    210                 215                 220                 
Gly Lys Cys Ser Ala Phe Pro Asp Val Pro Asp Lys Glu Asn Phe Glu
225                 230                 235                 240 
Ile Pro Ile Tyr Ser Lys Glu Pro Asn Ser Ala Ser Ser Thr His Gln
                245                 250                 255     
Met His Val Ser Leu Lys Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg
            260                 265                 270         
Leu Phe Arg Glu Lys Asp Asp Gly Met Asn Phe Thr Gln Cys His Thr
        275                 280                 285             
Ala Asn Ile Gln Thr Leu Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg
    290                 295                 300                 
Glu Ser Lys Gly Asn Asp Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp
305                 310                 315                 320 
Leu Thr Phe Asn His Thr Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe
                325                 330                 335     
Ser Glu Ile Glu Asn Gln Thr Gln Asn Ala Met Asp Val Thr Thr Gly
            340                 345                 350         
Tyr Gly Thr Lys Ala Ser Gly Asn Lys Thr Val Phe Lys Ser Lys Gln
        355                 360                 365             
Asn Thr Ala Phe Gln Asp Leu Ser Ile Asn Ser Ala Asp Lys Ile His
    370                 375                 380                 
Ile Thr Arg Ser His Ile Met Gly Ala Glu Thr His Ile Val Ser Gln
385                 390                 395                 400 
Thr Cys Asn Gln Asp Ala Arg Ile Leu Ala Met Thr Pro Glu Ser Ile
                405                 410                 415     
Tyr Ser Asn Pro Ser Ile Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser
            420                 425                 430         
Cys Asn Asp Ala Met Glu Met Thr Lys Cys Leu Ser Asn Met Arg Glu
        435                 440                 445             
Glu Lys Asn Leu Leu Lys His Asp Ser Asn Tyr Ser Lys Met Tyr Cys
    450                 455                 460                 
Asn Pro Asp Ala Met Ser Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly
465                 470                 475                 480 
Glu Glu Asn Met Asp Ile Thr Lys Ser His Thr Val Ala Ile Asp Asn
                485                 490                 495     
Gln Ile Phe Lys Gln Asp Gln Ser Asn Val Gln Ile Ala Ala Ala Pro
            500                 505                 510         
Thr Pro Glu Lys Glu Met Met Leu Gln Asn Leu Met Thr Thr Ser Glu
        515                 520                 525             
Asp Gly Lys Met Asn Val Asn Cys Asn Ser Val Pro His Val Ser Lys
    530                 535                 540                 
Glu Arg Ile Gln Gln Ser Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr
545                 550                 555                 560 
Asp Arg Lys Thr Glu Leu Leu Ser Gly Glu Asn Thr Asp Leu Thr Glu
                565                 570                 575     
Ser His Thr Ser Asn Leu Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn
            580                 585                 590         
Leu Ala Pro Glu Ser Thr Ser Glu Ser His Ser Gln Ser Lys Ser Ser
        595                 600                 605             
Ser Asp Glu Cys Glu Glu Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln
    610                 615                 620                 
Arg Ser Asp Ile Ile Ala Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys
625                 630                 635                 640 
Asp Lys Asp Trp Val Leu Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser
                645                 650                 655     
Pro Gln Ser Ala Asp Cys Asn Gln Glu Ile Ala Thr Ser His Asn Ile
            660                 665                 670         
Val Tyr Cys Gly Gly Val Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr
        675                 680                 685             
Val Ser Trp Glu Gln Ser Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser
    690                 695                 700                 
Ser Gly Gln Phe Ser Met Lys Asn His Asp Thr Ala Ile Ser Ser His
705                 710                 715                 720 
Thr Val Lys Ser Val Leu Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu
                725                 730                 735     
Arg Lys Ser Leu Ser Asn Pro Thr Pro Asp Tyr Cys His Asp Lys Met
            740                 745                 750         
Ile Ile Cys Ser Glu Glu Glu Gln Asn Met Asp Leu Thr Lys Ser His
        755                 760                 765             
Thr Val Val Ile Gly Phe Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys
    770                 775                 780                 
Thr Asn Leu Glu His Thr Thr Gly Gln Leu Thr Thr Met Asn Arg Gln
785                 790                 795                 800 
Ile Ala Val Lys Val Glu Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser
                805                 810                 815     
Gly Val Leu Lys Ser Asn Cys Ile Met Asp Val Leu Glu Asp Glu Ser
            820                 825                 830         
Val Gln Lys Pro Lys Phe Pro Lys Glu Lys Gln Asn Val Lys Ile Trp
        835                 840                 845             
Gly Arg Lys Ser Val Gly Gly Pro Lys Ile Asp Lys Thr Ile Val Phe
    850                 855                 860                 
Ser Glu Asp Asp Lys Asn Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile
865                 870                 875                 880 
Glu Ile Asn His Arg Pro Leu Leu Glu Lys Arg Asp Cys His Leu Val
                885                 890                 895     
Pro Leu Ala Gly Thr Ser Glu Thr Ile Leu Tyr Thr Cys Gly Gln Asp
            900                 905                 910         
Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu Glu Cys Lys Thr
        915                 920                 925             
Val Ser Pro Asp Glu Ile Thr Thr Arg Pro Met Asp Lys Thr Val Val
    930                 935                 940                 
Phe Val Asp Asn His Val Glu Leu Glu Met Thr Glu Ser His Thr Val
945                 950                 955                 960 
Phe Ile Asp Tyr Gln Glu Lys Glu Arg Thr Asp Arg Pro Asn Phe Glu
                965                 970                 975     
Leu Ser Gln Arg Lys Ser Leu Gly Thr Pro Thr Val Ile Cys Thr Pro
            980                 985                 990         
Thr Glu Glu Ser Val Phe Phe Pro Gly Asn Gly Glu Ser Asp Arg Leu
        995                 1000                1005            
Val Ala Asn Asp Ser Gln Leu Thr Pro Leu Glu Glu Trp Ser Asn Asn
    1010                1015                1020                
Arg Gly Pro Val Glu Val Ala Asp Asn Met Glu Leu Ser Lys Ser Ala
1025                1030                1035                1040
Thr Cys Lys Asn Ile Lys Asp Val Gln Ser Pro Gly Phe Leu Asn Glu
                1045                1050                1055    
Pro Leu Ser Ser Lys Ser Gln Arg Arg Lys Ser Leu Lys Leu Lys Asn
            1060                1065                1070        
Asp Lys Thr Ile Val Phe Ser Glu Asn His Lys Asn Asp Met Asp Ile
        1075                1080                1085            
Thr Gln Ser Cys Met Val Glu Ile Asp Asn Glu Ser Ala Leu Glu Asp
    1090                1095                1100                
Lys Glu Asp Phe His Leu Ala Gly Ala Ser Lys Thr Ile Leu Tyr Ser
1105                1110                1115                1120
Cys Gly Gln Asp Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu
                1125                1130                1135    
Glu Cys Lys Thr Leu Leu Pro Asn Glu Ile Ala Ile Arg Pro Met Asp
            1140                1145                1150        
Lys Thr Val Leu Phe Thr Asp Asn Tyr Ser Asp Leu Glu Val Thr Asp
        1155                1160                1165            
Ser His Thr Val Phe Ile Asp Cys Gln Ala Thr Glu Lys Ile Leu Glu
    1170                1175                1180                
Glu Asn Pro Lys Phe Gly Ile Gly Lys Gly Lys Asn Leu Gly Val Ser
1185                1190                1195                1200
Phe Pro Lys Asp Asn Ser Cys Val Gln Glu Ile Ala Glu Lys Gln Ala
                1205                1210                1215    
Leu Ala Val Gly Asn Lys Ile Val Leu His Thr Glu Gln Lys Gln Gln
            1220                1225                1230        
Leu Phe Ala Ala Thr Asn Arg Thr Thr Asn Glu Ile Ile Lys Phe His
        1235                1240                1245            
Ser Ala Ala Met Asp Glu Lys Val Ile Gly Lys Val Val Asp Gln Ala
    1250                1255                1260                
Cys Thr Leu Glu Lys Ala Gln Val Glu Ser Cys Gln Leu Asn Asn Arg
1265                1270                1275                1280
Asp Arg Arg Asn Val Asp Phe Thr Ser Ser His Ala Thr Ala Val Cys
                1285                1290                1295    
Gly Ser Ser Asp Asn Tyr Ser Cys Leu Ala Asn Val Ile Ser Cys Thr
            1300                1305                1310        
Asp Asn Leu Glu Gly Ser Ala Met Leu Leu Cys Asp Lys Asp Glu Glu
        1315                1320                1325            
Lys Ala His Tyr Cys Pro Val Gln Asn Asp Leu Ala Tyr Ala Asn Asp
    1330                1335                1340                
Phe Ala Ser Glu Tyr Tyr Leu Glu Ser Glu Gly Gln Pro Leu Ser Ala
1345                1350                1355                1360
Pro Cys Pro Leu Leu Glu Lys Glu Glu Val Ile Gln Thr Ser Thr Lys
                1365                1370                1375    
Gly Gln Leu Asp Cys Val Ile Thr Leu His Lys Asp Gln Asp Leu Ile
            1380                1385                1390        
Lys Asp Pro Arg Asn Leu Leu Ala Asn Gln Thr Leu Val Tyr Ser Gln
        1395                1400                1405            
Asp Leu Gly Glu Met Thr Lys Leu Asn Ser Lys Arg Val Ser Phe Lys
    1410                1415                1420                
Leu Pro Lys Asp Gln Met Lys Val Tyr Val Asp Asp Ile Tyr Val Ile
1425                1430                1435                1440
Pro Gln Pro His Phe Ser Thr Asp Gln Pro Pro Leu Pro Lys Lys Gly
                1445                1450                1455    
Gln Ser Ser Ile Asn Lys Glu Glu Val Ile Leu Ser Lys Ala Gly Asn
            1460                1465                1470        
Lys Ser Leu Asn Ile Ile Glu Asn Ser Ser Ala Pro Ile Cys Glu Asn
        1475                1480                1485            
Lys Pro Lys Ile Leu Asn Ser Glu Glu Trp Phe Ala Ala Ala Cys Lys
    1490                1495                1500                
Lys Glu Leu Lys Glu Asn Ile Gln Thr Thr Asn Tyr Asn Thr Ala Leu
1505                1510                1515                1520
Asp Phe His Ser Asn Ser Asp Val Thr Lys Gln Val Ile Gln Thr His
                1525                1530                1535    
Val Asn Ala Gly Glu Ala Pro Asp Pro Val Ile Thr Ser Asn Val Pro
            1540                1545                1550        
Cys Phe His Ser Ile Lys Pro Asn Leu Asn Asn Leu Asn Gly Lys Thr
        1555                1560                1565            
Gly Glu Phe Leu Ala Phe Gln Thr Val His Leu Pro Pro Leu Pro Glu
    1570                1575                1580                
Gln Leu Leu Glu Leu Gly Asn Lys Ala His Asn Asp Met His Ile Val
1585                1590                1595                1600
Gln Ala Thr Glu Ile His Asn Ile Asn Ile Ile Ser Ser Asn Ala Lys
                1605                1610                1615    
Asp Ser Arg Asp Glu Glu Asn Lys Lys Ser His Asn Gly Ala Glu Thr
            1620                1625                1630        
Thr Ser Leu Pro Pro Lys Thr Val Phe Lys Asp Lys Val Arg Arg Cys
        1635                1640                1645            
Ser Leu Gly Ile Phe Leu Pro Arg Leu Pro Asn Lys Arg Asn Cys Ser
    1650                1655                1660                
Val Thr Gly Ile Asp Asp Leu Glu Gln Ile Pro Ala Asp Thr Thr Asp
1665                1670                1675                1680
Ile Asn His Leu Glu Thr Gln Pro Val Ser Ser Lys Asp Ser Gly Ile
                1685                1690                1695    
Gly Ser Val Ala Gly Lys Leu Asn Leu Ser Pro Ser Gln Tyr Ile Asn
            1700                1705                1710        
Glu Glu Asn Leu Pro Val Tyr Pro Asp Glu Ile Asn Ser Ser Asp Ser
        1715                1720                1725            
Ile Tyr Ile Glu Thr Glu Glu Lys Ala Val Gly Thr Arg Arg Arg Arg
    1730                1735                1740                
Tyr Ser
1745    


<210> 8408
<211> 228
<212> PRT
<213> Homo sapiens

<400> 8408
Met Thr Met Gly Asp Lys Lys Ser Pro Thr Arg Pro Lys Arg Gln Ala
 1               5                  10                  15      
Lys Pro Ala Thr Asp Glu Gly Phe Trp Asp Cys Ser Val Cys Thr Phe
            20                  25                  30          
Arg Asn Ser Ala Glu Ala Phe Lys Cys Ser Ile Cys Asp Val Arg Lys
        35                  40                  45              
Gly Thr Ser Thr Arg Lys Pro Arg Ile Asn Ser Gln Leu Val Ala Gln
    50                  55                  60                  
Gln Val Ala Gln Gln Tyr Ala Thr Pro Pro Pro Pro Lys Lys Glu Lys
65                  70                  75                  80  
Lys Glu Lys Val Glu Lys Gln Asp Lys Glu Lys Pro Glu Lys Asp Lys
                85                  90                  95      
Glu Ile Ser Pro Ser Val Thr Lys Lys Asn Thr Asn Lys Lys Thr Lys
            100                 105                 110         
Pro Lys Ser Asp Ile Leu Lys Asp Pro Pro Ser Glu Ala Asn Ser Ile
        115                 120                 125             
Gln Ser Ala Asn Ala Thr Thr Lys Thr Ser Glu Thr Asn His Thr Ser
    130                 135                 140                 
Arg Pro Arg Leu Lys Asn Val Asp Arg Ser Thr Ala Gln Gln Leu Ala
145                 150                 155                 160 
Val Thr Val Gly Asn Val Thr Val Ile Ile Thr Asp Phe Lys Glu Lys
                165                 170                 175     
Thr Arg Ser Ser Ser Thr Ser Ser Ser Thr Val Thr Ser Ser Ala Gly
            180                 185                 190         
Ser Glu Gln Gln Asn Gln Ser Ser Ser Gly Ser Glu Ser Thr Asp Lys
        195                 200                 205             
Gly Ser Ser Arg Ser Ser Thr Pro Lys Gly Asp Met Ser Ala Val Asn
    210                 215                 220                 
Asp Glu Ser Phe
225             


<210> 8409
<211> 265
<212> PRT
<213> Homo sapiens

<400> 8409
Glu Asp Glu Val Ala Arg Ser Ala Lys Lys Met Asp Lys Met Val Gln
 1               5                  10                  15      
Glu Lys Asn Thr Ala Gly Ala Leu Gly Leu Leu Thr Glu Leu Gln Asn
            20                  25                  30          
Val Leu Glu Leu Leu Arg Ser Thr Gly Thr Gly Met Leu Leu Asn Val
        35                  40                  45              
Ser Leu Lys Gln Ser Ala Asp Glu Glu Val Thr Ser Leu Ala Lys Ser
    50                  55                  60                  
Leu Val Lys Ser Trp Lys Lys Leu Pro Asp Lys Pro Ser Ser Glu Lys
65                  70                  75                  80  
Asp Pro Lys Glu Lys Gln Ile Glu Pro Ala Met Thr Ser Gln Asn Ser
                85                  90                  95      
Lys Arg Asn Thr Ser Asp Ser Val Arg Met Lys Tyr Arg Glu Met Leu
            100                 105                 110         
Pro Ala Ala Leu Arg Thr Gly Asp Asp Cys Ile Glu Met Gly Thr Asp
        115                 120                 125             
Glu Glu Glu Leu Gly Ser Arg Thr Glu Glu Ala Ile Asp Pro Glu Arg
    130                 135                 140                 
Gly Asn Thr Gly Met Lys Tyr Lys Asn Arg Val Gln Ser Lys Ile Ser
145                 150                 155                 160 
Asn Leu Thr Asp Ala Lys Asn Pro Asp Leu Arg Lys Asn Ala Pro Cys
                165                 170                 175     
Gly Asn Ile Pro Pro Asp Leu Leu Ala Arg Met Thr Ala Glu Glu Met
            180                 185                 190         
Ala Ser Asp Glu Leu Lys Glu Met His Lys Asn Leu Thr Lys Glu Ala
        195                 200                 205             
Ile Arg Glu His Gln Met Ala Lys Thr Gly Gly Thr Gln Pro Asp Ser
    210                 215                 220                 
Leu Thr Cys Ala Lys Cys Lys Lys Lys Asn Cys Thr Ser Thr Gln Val
225                 230                 235                 240 
Gln Ala Cys Ser Ala Gly Glu Pro Met Thr Thr Phe Val Asp Cys Asn
                245                 250                 255     
Glu Cys Gly Asn Gln Gln Lys Phe Cys
            260                 265 


<210> 8410
<211> 309
<212> PRT
<213> Homo sapiens

<400> 8410
Asp Lys Gly Lys Ile Ile Lys Gln Gln Glu Thr Val Ile Ile Leu Glu
 1               5                  10                  15      
Asp Tyr Ala Asp Pro Tyr Asp Ala Lys Arg Thr Lys Gly Gln Arg Asp
            20                  25                  30          
Ala Glu Arg Val Gly Glu Asn Asp Gly Tyr Met Glu Pro Tyr Asp Ala
        35                  40                  45              
Gln Gln Met Ile Thr Glu Ile Arg Arg Arg Gly Ser Lys Asp Pro Leu
    50                  55                  60                  
Val Lys Ala Leu Gln Leu Leu Asp Ser Pro Cys Glu Pro Ala Asp Gly
65                  70                  75                  80  
Gly Leu Lys Ser Glu Thr Leu Ala Lys Arg Arg Ser Ser Lys Asp Leu
                85                  90                  95      
Leu Gly Lys Pro Pro Gln Leu Tyr Asp Thr Pro Tyr Glu Pro Ala Glu
            100                 105                 110         
Gly Gly Pro Arg Ala Glu Gly Lys Ala Arg Pro Pro Asp Ser Arg Leu
        115                 120                 125             
Pro Glu Asn Asp Glu Arg Pro Ala Ala Glu Tyr Glu Gln Pro Trp Glu
    130                 135                 140                 
Trp Lys Lys Glu Gln Ile Val Arg Ala Leu Ser Val Gln Phe Glu Gly
145                 150                 155                 160 
Ala Glu Arg Pro Ser Phe Arg Glu Glu Thr Val Arg Gln His His Arg
                165                 170                 175     
Gln Lys Ser Trp Thr Gln Lys Ile Leu Lys Pro Ala Leu Ser Asp His
            180                 185                 190         
Ser Glu Gly Glu Lys Val Asp Pro Gly Leu Pro Leu Glu Lys Gln Pro
        195                 200                 205             
Trp Tyr His Gly Ala Ile Ser Arg Ala Glu Ala Glu Ser Arg Leu Gln
    210                 215                 220                 
Pro Cys Lys Glu Ala Gly Tyr Leu Val Arg Asn Ser Glu Ser Gly Asn
225                 230                 235                 240 
Ser Arg Tyr Ser Ile Ala Leu Lys Thr Ser Gln Gly Cys Val His Ile
                245                 250                 255     
Ile Val Ala Gln Thr Lys Asp Asn Lys Tyr Thr Leu Asn Gln Thr Ser
            260                 265                 270         
Ala Val Phe Asp Ser Ile Pro Glu Val Val His Tyr Tyr Ser Asn Glu
        275                 280                 285             
Lys Leu Pro Phe Lys Gly Ala Glu His Met Thr Leu Leu Tyr Pro Val
    290                 295                 300                 
His Ser Lys Leu His
305                 


<210> 8411
<211> 1046
<212> PRT
<213> Homo sapiens

<400> 8411
Met Asn Asn Val Tyr Thr Arg Lys His Cys Pro Ile Phe Thr Tyr Ser
 1               5                  10                  15      
Val Lys Glu Leu Asp Ser Val Ser Asp Tyr Ala Glu Lys Glu Asn Thr
            20                  25                  30          
Ile Ala Lys Ala Leu Glu Asp Leu Lys Ala Asn Phe Tyr Cys Glu Leu
        35                  40                  45              
Cys Asp Lys Gln Tyr Tyr Lys His Gln Glu Phe Asp Asn His Ile Asn
    50                  55                  60                  
Ser Tyr Asp His Ala His Lys Gln Arg Leu Lys Glu Leu Lys Gln Arg
65                  70                  75                  80  
Glu Phe Ala Arg Asn Val Ala Ser Lys Ser Arg Lys Asp Glu Arg Lys
                85                  90                  95      
Gln Glu Lys Ala Leu Gln Arg Leu His Lys Leu Ala Glu Leu Arg Lys
            100                 105                 110         
Glu Thr Val Cys Ala Pro Gly Ser Gly Pro Met Phe Lys Ser Thr Thr
        115                 120                 125             
Val Thr Val Arg Glu Asn Cys Asn Glu Ile Ser Gln Arg Val Val Val
    130                 135                 140                 
Asp Ser Val Asn Asn Gln Gln Asp Phe Lys Tyr Thr Leu Ile His Ser
145                 150                 155                 160 
Glu Glu Asn Thr Lys Asp Ala Thr Thr Val Ala Glu Asp Pro Glu Ser
                165                 170                 175     
Ala Asn Asn Tyr Thr Ala Lys Asn Asn Gln Val Gly Asp Gln Ala Gln
            180                 185                 190         
Gly Ile His Arg His Lys Ile Gly Phe Ser Phe Ala Phe Pro Lys Lys
        195                 200                 205             
Ala Ser Val Lys Leu Glu Ser Ser Ala Ala Ala Phe Ser Glu Tyr Ser
    210                 215                 220                 
Asp Asp Ala Ser Val Gly Lys Gly Phe Ser Arg Lys Ser Arg Phe Val
225                 230                 235                 240 
Pro Ser Ala Cys His Leu Gln Gln Ser Ser Pro Thr Asp Val Leu Leu
                245                 250                 255     
Ser Ser Glu Glu Lys Thr Asn Ser Phe His Pro Pro Glu Ala Met Cys
            260                 265                 270         
Arg Asp Lys Glu Thr Val Gln Thr Gln Glu Ile Lys Glu Val Ser Ser
        275                 280                 285             
Glu Lys Asp Ala Leu Leu Leu Pro Ser Phe Cys Lys Phe Gln Leu Gln
    290                 295                 300                 
Leu Ser Ser Asp Ala Asp Asn Cys Gln Asn Ser Val Pro Leu Ala Asp
305                 310                 315                 320 
Gln Ile Pro Leu Glu Ser Val Val Ile Asn Glu Asp Ile Pro Val Ser
                325                 330                 335     
Gly Asn Ser Phe Glu Leu Leu Gly Asn Lys Ser Thr Val Leu Asp Met
            340                 345                 350         
Ser Asn Asp Cys Ile Ser Val Gln Ala Thr Thr Glu Glu Asn Val Lys
        355                 360                 365             
His Asn Glu Ala Ser Thr Thr Glu Val Glu Asn Lys Asn Gly Pro Glu
    370                 375                 380                 
Thr Leu Ala Pro Ser Asn Thr Glu Glu Val Asn Ile Thr Ile His Lys
385                 390                 395                 400 
Lys Thr Asn Phe Cys Lys Arg Gln Cys Glu Pro Phe Val Pro Val Leu
                405                 410                 415     
Asn Lys His Arg Ser Thr Val Leu Gln Trp Pro Ser Glu Met Leu Val
            420                 425                 430         
Tyr Thr Thr Thr Lys Pro Ser Ile Ser Tyr Ser Cys Asn Pro Leu Cys
        435                 440                 445             
Phe Asp Phe Lys Ser Thr Lys Val Asn Asn Asn Leu Asp Lys Asn Lys
    450                 455                 460                 
Pro Asp Leu Lys Asp Leu Cys Ser Gln Gln Lys Gln Glu Asp Ile Cys
465                 470                 475                 480 
Met Gly Pro Leu Ser Asp Tyr Lys Asp Val Ser Thr Glu Gly Leu Thr
                485                 490                 495     
Asp Tyr Glu Ile Gly Ser Ser Lys Asn Lys Cys Ser Gln Val Thr Pro
            500                 505                 510         
Leu Leu Ala Asp Asp Ile Leu Ser Ser Ser Cys Asp Ser Gly Lys Asn
        515                 520                 525             
Glu Asn Thr Gly Gln Arg Tyr Lys Asn Ile Ser Cys Lys Ile Arg Glu
    530                 535                 540                 
Thr Glu Lys Tyr Asn Phe Thr Lys Ser Gln Ile Lys Gln Asp Thr Leu
545                 550                 555                 560 
Asp Glu Lys Tyr Asn Lys Ile Arg Leu Lys Glu Thr His Glu Tyr Trp
                565                 570                 575     
Phe His Lys Ser Arg Arg Lys Lys Lys Arg Lys Lys Leu Cys Gln His
            580                 585                 590         
His His Met Glu Lys Thr Lys Glu Ser Glu Thr Arg Cys Lys Met Glu
        595                 600                 605             
Ala Glu Asn Ser Tyr Thr Glu Asn Ala Gly Lys Tyr Leu Leu Glu Pro
    610                 615                 620                 
Ile Ser Glu Lys Gln Tyr Leu Ala Ala Glu Gln Leu Leu Asp Ser His
625                 630                 635                 640 
Gln Leu Leu Asp Lys Arg Pro Lys Ser Glu Ser Ile Ser Leu Ser Asp
                645                 650                 655     
Asn Glu Glu Met Cys Lys Thr Trp Asn Thr Glu Tyr Asn Thr Tyr Asp
            660                 665                 670         
Thr Ile Ser Ser Lys Asn His Cys Lys Lys Asn Thr Ile Leu Leu Asn
        675                 680                 685             
Gly Gln Ser Asn Ala Thr Met Ile His Ser Gly Lys His Asn Leu Thr
    690                 695                 700                 
Tyr Ser Arg Thr Tyr Cys Cys Trp Lys Thr Lys Met Ser Ser Cys Ser
705                 710                 715                 720 
Gln Asp His Arg Ser Leu Val Leu Gln Asn Asp Met Lys His Met Ser
                725                 730                 735     
Gln Asn Gln Ala Val Lys Arg Gly Tyr Asn Ser Val Met Asn Glu Ser
            740                 745                 750         
Glu Arg Phe Tyr Arg Lys Arg Arg Gln His Ser His Ser Tyr Ser Ser
        755                 760                 765             
Asp Glu Ser Leu Asn Arg Gln Asn His Leu Pro Glu Glu Phe Leu Arg
    770                 775                 780                 
Pro Pro Ser Thr Ser Val Ala Pro Cys Lys Pro Lys Lys Lys Arg Arg
785                 790                 795                 800 
Arg Lys Arg Gly Arg Phe His Pro Gly Phe Glu Thr Leu Glu Leu Lys
                805                 810                 815     
Glu Asn Thr Asp Tyr Pro Val Lys Asp Asn Ser Ser Leu Asn Pro Leu
            820                 825                 830         
Asp Arg Leu Ile Ser Glu Asp Lys Lys Glu Lys Met Lys Pro Gln Glu
        835                 840                 845             
Val Ala Lys Ile Glu Arg Asn Ser Glu Gln Thr Asn Gln Leu Arg Asn
    850                 855                 860                 
Lys Leu Ser Phe His Pro Asn Asn Leu Leu Pro Ser Glu Thr Asn Gly
865                 870                 875                 880 
Glu Thr Glu His Leu Glu Met Glu Thr Thr Ser Gly Glu Leu Ser Asp
                885                 890                 895     
Val Ser Asn Asp Pro Thr Thr Ser Val Cys Val Ala Ser Ala Pro Thr
            900                 905                 910         
Lys Glu Ala Ile Asp Asn Thr Leu Leu Glu His Lys Glu Arg Ser Glu
        915                 920                 925             
Asn Ile Asn Leu Asn Glu Lys Gln Ile Pro Phe Gln Val Pro Asn Ile
    930                 935                 940                 
Glu Arg Asn Phe Arg Gln Ser Gln Pro Lys Ser Tyr Leu Cys His Tyr
945                 950                 955                 960 
Glu Leu Ala Glu Ala Leu Pro Gln Gly Lys Met Asn Glu Thr Pro Thr
                965                 970                 975     
Glu Trp Leu Arg Tyr Asn Ser Gly Ile Leu Asn Thr Gln Pro Pro Leu
            980                 985                 990         
Pro Phe Lys Glu Ala His Val Ser Gly His Thr Phe Val Thr Ala Glu
        995                 1000                1005            
Gln Ile Leu Ala Pro Leu Ala Leu Pro Glu Gln Ala Leu Leu Ile Pro
    1010                1015                1020                
Leu Glu Asn His Asp Lys Phe Lys Asn Val Pro Tyr Ala Asn His Ser
1025                1030                1035                1040
Ser Phe Arg Ser Ser Ser
                1045    


<210> 8412
<211> 1209
<212> PRT
<213> Homo sapiens

<400> 8412
Met Glu Cys Tyr Tyr Ile Val Ile Ser Ser Thr His Leu Ser Asn Gly
 1               5                  10                  15      
His Phe Arg Asn Ile Lys Gly Val Phe Arg Gly Pro Leu Ser Lys Asn
            20                  25                  30          
Gly Asn Lys Thr Leu Asp Tyr Ala Glu Lys Glu Asn Thr Ile Ala Lys
        35                  40                  45              
Ala Leu Glu Asp Leu Lys Ala Asn Phe Tyr Cys Glu Leu Cys Asp Lys
    50                  55                  60                  
Gln Tyr Tyr Lys His Gln Glu Phe Asp Asn His Ile Asn Ser Tyr Asp
65                  70                  75                  80  
His Ala His Lys Gln Arg Leu Lys Glu Leu Lys Gln Arg Glu Phe Ala
                85                  90                  95      
Arg Asn Val Ala Ser Lys Ser Arg Lys Asp Glu Arg Lys Gln Glu Lys
            100                 105                 110         
Ala Leu Gln Arg Leu His Lys Leu Ala Glu Leu Arg Lys Glu Thr Val
        115                 120                 125             
Cys Ala Pro Gly Ser Gly Pro Met Phe Lys Ser Thr Thr Val Thr Val
    130                 135                 140                 
Arg Glu Asn Cys Asn Glu Ile Ser Gln Arg Val Val Val Asp Ser Val
145                 150                 155                 160 
Asn Asn Gln Gln Asp Phe Lys Tyr Thr Leu Ile His Ser Glu Glu Asn
                165                 170                 175     
Thr Lys Asp Ala Thr Thr Val Ala Glu Asp Pro Glu Ser Ala Asn Asn
            180                 185                 190         
Tyr Thr Ala Lys Asn Asn Gln Val Gly Asp Gln Ala Gln Gly Ile His
        195                 200                 205             
Arg His Lys Ile Gly Phe Ser Phe Ala Phe Pro Lys Lys Ala Ser Val
    210                 215                 220                 
Lys Leu Glu Ser Ser Ala Ala Ala Phe Ser Glu Tyr Ser Asp Asp Ala
225                 230                 235                 240 
Ser Val Gly Lys Gly Phe Ser Arg Lys Ser Arg Phe Val Pro Ser Ala
                245                 250                 255     
Cys His Leu Gln Gln Ser Ser Pro Thr Asp Val Leu Leu Ser Ser Glu
            260                 265                 270         
Glu Lys Thr Asn Ser Phe His Pro Pro Glu Ala Met Cys Arg Asp Lys
        275                 280                 285             
Glu Thr Val Gln Thr Gln Glu Ile Lys Glu Val Ser Ser Glu Lys Asp
    290                 295                 300                 
Ala Leu Leu Leu Pro Ser Phe Cys Lys Phe Gln Leu Gln Leu Ser Ser
305                 310                 315                 320 
Asp Ala Asp Asn Cys Gln Asn Ser Val Pro Leu Ala Asp Gln Ile Pro
                325                 330                 335     
Leu Glu Ser Val Val Ile Asn Glu Asp Ile Pro Val Ser Gly Asn Ser
            340                 345                 350         
Phe Glu Leu Leu Gly Asn Lys Ser Thr Val Leu Asp Met Ser Asn Asp
        355                 360                 365             
Cys Ile Ser Val Gln Ala Thr Thr Glu Glu Asn Val Lys His Asn Glu
    370                 375                 380                 
Ala Ser Thr Thr Glu Val Glu Asn Lys Asn Gly Pro Glu Thr Leu Ala
385                 390                 395                 400 
Pro Ser Asn Thr Glu Glu Val Asn Ile Thr Ile His Lys Lys Thr Asn
                405                 410                 415     
Phe Cys Lys Arg Gln Cys Glu Pro Phe Val Pro Val Leu Asn Lys His
            420                 425                 430         
Arg Ser Thr Val Leu Gln Trp Pro Ser Glu Met Leu Val Tyr Thr Thr
        435                 440                 445             
Thr Lys Pro Ser Ile Ser Tyr Ser Cys Asn Pro Leu Cys Phe Asp Phe
    450                 455                 460                 
Lys Ser Thr Lys Val Asn Asn Asn Leu Asp Lys Asn Lys Pro Asp Leu
465                 470                 475                 480 
Lys Asp Leu Cys Ser Gln Gln Lys Gln Glu Asp Ile Cys Met Gly Pro
                485                 490                 495     
Leu Ser Asp Tyr Lys Asp Val Ser Thr Glu Gly Leu Thr Asp Tyr Glu
            500                 505                 510         
Ile Gly Ser Ser Lys Asn Lys Cys Ser Gln Val Thr Pro Leu Leu Ala
        515                 520                 525             
Asp Asp Ile Leu Ser Ser Ser Cys Asp Ser Gly Lys Asn Glu Asn Thr
    530                 535                 540                 
Gly Gln Arg Tyr Lys Asn Ile Ser Cys Lys Ile Arg Glu Thr Glu Lys
545                 550                 555                 560 
Tyr Asn Phe Thr Lys Ser Gln Ile Lys Gln Asp Thr Leu Asp Glu Lys
                565                 570                 575     
Tyr Asn Lys Ile Arg Leu Lys Glu Thr His Glu Tyr Trp Phe His Lys
            580                 585                 590         
Ser Arg Arg Lys Lys Lys Arg Lys Lys Leu Cys Gln His His His Met
        595                 600                 605             
Glu Lys Thr Lys Glu Ser Glu Thr Arg Cys Lys Met Glu Ala Glu Asn
    610                 615                 620                 
Ser Tyr Thr Glu Asn Ala Gly Lys Tyr Leu Leu Glu Pro Ile Ser Glu
625                 630                 635                 640 
Lys Gln Tyr Leu Ala Ala Glu Gln Leu Leu Asp Ser His Gln Leu Leu
                645                 650                 655     
Asp Lys Arg Pro Lys Ser Glu Ser Ile Ser Leu Ser Asp Asn Glu Glu
            660                 665                 670         
Met Cys Lys Thr Trp Asn Thr Glu Tyr Asn Thr Tyr Asp Thr Ile Ser
        675                 680                 685             
Ser Lys Asn His Cys Lys Lys Asn Thr Ile Leu Leu Asn Gly Gln Ser
    690                 695                 700                 
Asn Ala Thr Met Ile His Ser Gly Lys His Asn Leu Thr Tyr Ser Arg
705                 710                 715                 720 
Thr Tyr Cys Cys Trp Lys Thr Lys Met Ser Ser Cys Ser Gln Asp His
                725                 730                 735     
Arg Ser Leu Val Leu Gln Asn Asp Met Lys His Met Ser Gln Asn Gln
            740                 745                 750         
Ala Val Lys Arg Gly Tyr Asn Ser Val Met Asn Glu Ser Glu Arg Phe
        755                 760                 765             
Tyr Arg Lys Arg Arg Gln His Ser His Ser Tyr Ser Ser Asp Glu Ser
    770                 775                 780                 
Leu Asn Arg Gln Asn His Leu Pro Glu Glu Phe Leu Arg Pro Pro Ser
785                 790                 795                 800 
Thr Ser Val Ala Pro Cys Lys Pro Lys Lys Lys Arg Arg Arg Lys Arg
                805                 810                 815     
Gly Arg Phe His Pro Gly Phe Glu Thr Leu Glu Leu Lys Glu Asn Thr
            820                 825                 830         
Asp Tyr Pro Val Lys Asp Asn Ser Ser Leu Asn Pro Leu Asp Arg Leu
        835                 840                 845             
Ile Ser Glu Asp Lys Lys Glu Lys Met Lys Pro Gln Glu Val Ala Lys
    850                 855                 860                 
Ile Glu Arg Asn Ser Glu Gln Thr Asn Gln Leu Arg Asn Lys Leu Ser
865                 870                 875                 880 
Phe His Pro Asn Asn Leu Leu Pro Ser Glu Thr Asn Gly Glu Thr Glu
                885                 890                 895     
His Leu Glu Met Glu Thr Thr Ser Gly Glu Leu Ser Asp Val Ser Asn
            900                 905                 910         
Asp Pro Thr Thr Ser Val Cys Val Ala Ser Ala Pro Thr Lys Glu Ala
        915                 920                 925             
Ile Asp Asn Thr Leu Leu Glu His Lys Glu Arg Ser Glu Asn Ile Asn
    930                 935                 940                 
Leu Asn Glu Lys Gln Ile Pro Phe Gln Val Pro Asn Ile Glu Arg Asn
945                 950                 955                 960 
Phe Arg Gln Ser Gln Pro Lys Ser Tyr Leu Cys His Tyr Glu Leu Ala
                965                 970                 975     
Glu Ala Leu Pro Gln Gly Lys Met Asn Glu Thr Pro Thr Glu Trp Leu
            980                 985                 990         
Arg Tyr Asn Ser Gly Ile Leu Asn Thr Gln Pro Pro Leu Pro Phe Lys
        995                 1000                1005            
Glu Ala His Val Ser Gly His Thr Phe Val Thr Ala Glu Gln Ile Leu
    1010                1015                1020                
Ala Pro Leu Ala Leu Pro Glu Gln Ala Leu Leu Ile Pro Leu Glu Asn
1025                1030                1035                1040
His Asp Lys Phe Lys Asn Val Pro Cys Glu Val Tyr Gln His Ile Leu
                1045                1050                1055    
Gln Pro Asn Met Leu Ala Asn Lys Val Lys Phe Thr Phe Pro Pro Ala
            1060                1065                1070        
Ala Leu Pro Pro Pro Ser Thr Pro Leu Gln Pro Leu Pro Leu Gln Gln
        1075                1080                1085            
Ser Leu Cys Ser Thr Ser Val Thr Thr Ile His His Thr Val Leu Gln
    1090                1095                1100                
Gln His Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly
1105                1110                1115                1120
Thr Phe Lys Val Leu Gln Pro His Gln Gln Phe Leu Ser Gln Ile Pro
                1125                1130                1135    
Ala Leu Thr Arg Thr Ser Leu Pro Gln Leu Ser Val Gly Pro Val Gly
            1140                1145                1150        
Pro Arg Leu Cys Pro Gly Asn Gln Pro Thr Phe Val Ala Pro Pro Gln
        1155                1160                1165            
Met Pro Ile Ile Pro Ala Ser Val Leu His Pro Ser His Leu Ala Phe
    1170                1175                1180                
Pro Ser Leu Pro His Ala Leu Phe Pro Ser Leu Leu Ser Pro His Pro
1185                1190                1195                1200
Thr Val Ile Pro Leu Gln Pro Leu Phe
                1205                


<210> 8413
<211> 479
<212> PRT
<213> Homo sapiens

<400> 8413
Met Asp Glu Thr Ser Pro Leu Val Ser Pro Glu Arg Ala Gln Pro Pro
 1               5                  10                  15      
Asp Tyr Thr Phe Pro Ser Gly Ser Gly Ala His Phe Pro Gln Val Pro
            20                  25                  30          
Gly Gly Ala Val Arg Val Ala Ala Ala Ala Gly Ser Gly Pro Ser Pro
        35                  40                  45              
Pro Gly Ser Pro Gly His Asp Arg Glu Arg Gln Pro Leu Leu Asp Arg
    50                  55                  60                  
Ala Arg Gly Ala Ala Ala Gln Gly Gln Thr Gln Thr Val Ala Ala Gln
65                  70                  75                  80  
Ala Gln Ala Leu Ala Ala Gln Ala Ala Ala Ala Ala His Ala Ala Gln
                85                  90                  95      
Ala His Arg Glu Arg Asn Glu Phe Pro Glu Asp Pro Glu Phe Glu Ala
            100                 105                 110         
Val Val Arg Gln Ala Glu Leu Ala Ile Glu Arg Cys Ile Phe Pro Glu
        115                 120                 125             
Arg Ile Tyr Gln Gly Ser Ser Gly Ser Tyr Phe Val Lys Asp Pro Gln
    130                 135                 140                 
Gly Arg Ile Ile Ala Val Phe Lys Pro Lys Asn Glu Glu Pro Tyr Gly
145                 150                 155                 160 
His Leu Asn Pro Lys Trp Thr Lys Trp Leu Gln Lys Leu Cys Cys Pro
                165                 170                 175     
Cys Cys Phe Gly Arg Asp Cys Leu Val Leu Asn Gln Gly Tyr Leu Ser
            180                 185                 190         
Glu Ala Gly Ala Ser Leu Val Asp Gln Lys Leu Glu Leu Asn Ile Val
        195                 200                 205             
Pro Arg Thr Lys Val Val Tyr Leu Ala Ser Glu Thr Phe Asn Tyr Ser
    210                 215                 220                 
Ala Ile Asp Arg Val Lys Ser Arg Gly Lys Arg Leu Ala Leu Glu Lys
225                 230                 235                 240 
Val Pro Lys Val Gly Gln Arg Phe Asn Arg Ile Gly Leu Pro Pro Lys
                245                 250                 255     
Val Gly Ser Phe Gln Leu Phe Val Glu Gly Tyr Lys Asp Ala Asp Tyr
            260                 265                 270         
Trp Leu Arg Arg Phe Glu Ala Glu Pro Leu Pro Glu Asn Thr Asn Arg
        275                 280                 285             
Gln Leu Leu Leu Gln Phe Glu Arg Leu Val Val Leu Asp Tyr Ile Ile
    290                 295                 300                 
Arg Asn Thr Asp Arg Gly Asn Asp Asn Trp Leu Ile Lys Tyr Asp Cys
305                 310                 315                 320 
Pro Met Asp Ser Ser Ser Ser Arg Asp Thr Asp Trp Val Val Val Lys
                325                 330                 335     
Glu Pro Val Ile Lys Val Ala Ala Ile Asp Asn Gly Leu Ala Phe Pro
            340                 345                 350         
Leu Lys His Pro Asp Ser Trp Arg Ala Tyr Pro Phe Tyr Trp Ala Trp
        355                 360                 365             
Leu Pro Gln Ala Lys Val Pro Phe Ser Gln Glu Ile Lys Asp Leu Ile
    370                 375                 380                 
Leu Pro Lys Ile Ser Asp Pro Asn Phe Val Lys Asp Leu Glu Glu Asp
385                 390                 395                 400 
Leu Tyr Glu Leu Phe Lys Lys Asp Pro Gly Phe Asp Arg Gly Gln Phe
                405                 410                 415     
His Lys Gln Ile Ala Val Met Arg Gly Gln Ile Leu Asn Leu Thr Gln
            420                 425                 430         
Ala Leu Lys Asp Asn Lys Ser Pro Leu His Leu Val Gln Met Pro Pro
        435                 440                 445             
Val Ile Val Glu Thr Ala Arg Ser His Gln Arg Ser Ser Ser Glu Ser
    450                 455                 460                 
Tyr Thr Gln Ser Phe Gln Ser Arg Lys Pro Phe Phe Ser Trp Trp
465                 470                 475                 


<210> 8414
<211> 408
<212> PRT
<213> Homo sapiens

<400> 8414
Met Thr Ser Lys Gly Pro Glu Glu Glu His Pro Ser Val Thr Leu Phe
 1               5                  10                  15      
Arg Gln Tyr Leu Arg Ile Arg Thr Val Gln Pro Lys Pro Asp Tyr Gly
            20                  25                  30          
Ala Ala Val Ala Phe Phe Glu Glu Thr Ala Arg Gln Leu Gly Leu Gly
        35                  40                  45              
Cys Gln Lys Val Glu Val Ala Pro Gly Tyr Val Val Thr Val Leu Thr
    50                  55                  60                  
Trp Pro Gly Thr Asn Pro Thr Leu Ser Ser Ile Leu Leu Asn Ser His
65                  70                  75                  80  
Thr Asp Val Val Pro Val Phe Lys Glu His Trp Ser His Asp Pro Phe
                85                  90                  95      
Glu Ala Phe Lys Asp Ser Glu Gly Tyr Ile Tyr Ala Arg Gly Ala Gln
            100                 105                 110         
Asp Met Lys Cys Val Ser Ile Gln Tyr Leu Glu Ala Val Arg Arg Leu
        115                 120                 125             
Lys Val Glu Gly His Arg Phe Pro Arg Thr Ile His Met Thr Phe Val
    130                 135                 140                 
Pro Asp Glu Glu Val Gly Gly His Gln Gly Met Glu Leu Phe Val Gln
145                 150                 155                 160 
Arg Pro Glu Phe His Ala Leu Arg Ala Gly Phe Ala Leu Asp Glu Gly
                165                 170                 175     
Ile Ala Asn Pro Thr Asp Ala Phe Thr Val Phe Tyr Ser Glu Arg Ser
            180                 185                 190         
Pro Trp Trp Val Arg Val Thr Ser Thr Gly Arg Pro Gly His Ala Ser
        195                 200                 205             
Arg Phe Met Glu Asp Thr Ala Ala Glu Lys Leu His Lys Val Val Asn
    210                 215                 220                 
Ser Ile Leu Ala Phe Arg Glu Lys Glu Trp Gln Arg Leu Gln Ser Asn
225                 230                 235                 240 
Pro His Leu Lys Glu Gly Ser Val Thr Ser Val Asn Leu Thr Lys Leu
                245                 250                 255     
Glu Gly Gly Val Ala Tyr Asn Val Ile Pro Ala Thr Met Ser Ala Ser
            260                 265                 270         
Phe Asp Phe Arg Val Ala Pro Asp Val Asp Phe Lys Ala Phe Glu Glu
        275                 280                 285             
Gln Leu Gln Ser Trp Cys Gln Ala Ala Gly Glu Gly Val Thr Leu Glu
    290                 295                 300                 
Phe Ala Gln Lys Trp Met His Pro Gln Val Thr Pro Thr Asp Asp Ser
305                 310                 315                 320 
Asn Pro Trp Trp Ala Ala Phe Ser Arg Val Cys Lys Asp Met Asn Leu
                325                 330                 335     
Thr Leu Glu Pro Glu Ile Met Pro Ala Ala Thr Asp Asn Arg Tyr Ile
            340                 345                 350         
Arg Ala Val Gly Val Pro Ala Leu Gly Phe Ser Pro Met Asn Arg Thr
        355                 360                 365             
Pro Val Leu Leu His Asp His Asp Glu Arg Leu His Glu Ala Val Phe
    370                 375                 380                 
Leu Arg Gly Val Asp Ile Tyr Thr Arg Leu Leu Pro Ala Leu Ala Ser
385                 390                 395                 400 
Val Pro Ala Leu Pro Ser Asp Ser
                405             


<210> 8415
<211> 2586
<212> PRT
<213> Homo sapiens

<400> 8415
Pro Ser Pro Arg Pro His His Asp Arg Arg Gly Phe Pro Arg Leu Ala
 1               5                  10                  15      
Glu Thr Leu Gln His Pro Met Cys Pro Leu Pro Leu Val Ala Ser Ala
            20                  25                  30          
Gly His His Arg His His Arg Leu Leu Leu Leu Leu Ala Pro Gln Ala
        35                  40                  45              
Pro Glu Arg Glu Ala Ser Asp Glu Ile Val Phe Ser Gly Arg Ser Arg
    50                  55                  60                  
Ser Arg Asp Ala Val Leu Arg Ser His His Phe Arg Ser Glu Gly Phe
65                  70                  75                  80  
Arg Ala Ser Pro Arg His Leu Arg Arg Arg Val Ala Ala Ala Ala Ala
                85                  90                  95      
Ala Arg Leu Glu Glu Val Lys Pro Val Val Glu Val His His Gln Ser
            100                 105                 110         
Glu Gln Glu Thr Ser Val Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg
        115                 120                 125             
Val Gln Pro Glu Phe Tyr His Ser Val Gln Gly Ala Ser Ile Arg Arg
    130                 135                 140                 
Pro Ser Ser Gly Asn Ala Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala
145                 150                 155                 160 
Asp Phe Ser Asp Glu Asp Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser
                165                 170                 175     
Pro Ala Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro Lys His Glu Arg
            180                 185                 190         
Ser Lys Arg Lys Ile Gln Gly Gly Ser Val Leu Asp Pro Ala Glu Arg
        195                 200                 205             
Ala Val Leu Arg Ile Ala Asp Glu Arg Asp Lys Val Gln Lys Lys Thr
    210                 215                 220                 
Phe Thr Lys Trp Ile Asn Gln His Leu Met Lys Val Arg Lys His Val
225                 230                 235                 240 
Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu
                245                 250                 255     
Leu Glu Val Leu Ser Gly Asp Thr Leu Pro Arg Glu Lys Gly Arg Met
            260                 265                 270         
Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys
        275                 280                 285             
Arg Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp
    290                 295                 300                 
Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His
305                 310                 315                 320 
Phe Gln Ile Ser Asp Ile His Val Thr Gly Glu Ser Glu Asp Met Ser
                325                 330                 335     
Ala Lys Glu Arg Leu Leu Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr
            340                 345                 350         
Ala Gly Ile Arg Cys Glu Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys
        355                 360                 365             
Leu Phe Asn Ala Ile Ile His Lys Tyr Arg Pro Asp Leu Ile Asp Met
    370                 375                 380                 
Asn Thr Val Ala Val Gln Ser Asn Leu Ala Asn Leu Glu His Ala Phe
385                 390                 395                 400 
Tyr Val Ala Glu Lys Ile Gly Val Ile Arg Leu Leu Asp Pro Glu Asp
                405                 410                 415     
Val Asp Val Ser Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser
            420                 425                 430         
Ser Leu Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile
        435                 440                 445             
Gly Ala Asn Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val
    450                 455                 460                 
Asn Tyr Leu Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu
465                 470                 475                 480 
Arg Thr Phe Pro Asn Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln
                485                 490                 495     
Tyr Leu Gln Phe Lys Glu Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys
            500                 505                 510         
Ser Lys Ile Lys Arg Leu Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe
        515                 520                 525             
Gly Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys
    530                 535                 540                 
Glu Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu
545                 550                 555                 560 
Arg Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg
                565                 570                 575     
Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly
            580                 585                 590         
Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe
        595                 600                 605             
Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu
    610                 615                 620                 
Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr
625                 630                 635                 640 
Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu
                645                 650                 655     
Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg
            660                 665                 670         
Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln
        675                 680                 685             
Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser
    690                 695                 700                 
Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr
705                 710                 715                 720 
Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr
                725                 730                 735     
Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser
            740                 745                 750         
Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile
        755                 760                 765             
Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu
    770                 775                 780                 
Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp
785                 790                 795                 800 
Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro
                805                 810                 815     
Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile
            820                 825                 830         
Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln
        835                 840                 845             
Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu
    850                 855                 860                 
Glu Ser Gln Tyr Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn Thr Ser
865                 870                 875                 880 
Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg
                885                 890                 895     
Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val
            900                 905                 910         
Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp
        915                 920                 925             
Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile
    930                 935                 940                 
Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro
945                 950                 955                 960 
Ala Arg Leu Thr Ile Glu Val Lys Leu Glu Ser Val Met Val Leu Val
                965                 970                 975     
Glu Tyr Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu
            980                 985                 990         
Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr
        995                 1000                1005            
Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn
    1010                1015                1020                
Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser
1025                1030                1035                1040
Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu
                1045                1050                1055    
Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala
            1060                1065                1070        
Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys
        1075                1080                1085            
Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile
    1090                1095                1100                
Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg
1105                1110                1115                1120
Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro
                1125                1130                1135    
Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu
            1140                1145                1150        
Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp His
        1155                1160                1165            
Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu Ile
    1170                1175                1180                
Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Val Ser Met
1185                1190                1195                1200
Asn Leu Ile Lys Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser
                1205                1210                1215    
Asn Leu Gln Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser
            1220                1225                1230        
Gln Val Phe Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn
        1235                1240                1245            
Val Cys Lys Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu
    1250                1255                1260                
Glu Gln Glu Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn
1265                1270                1275                1280
Ile Arg Leu Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile
                1285                1290                1295    
Arg Thr Pro Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile
            1300                1305                1310        
Thr Glu Gln Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp
        1315                1320                1325            
Leu Gly Thr Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala
    1330                1335                1340                
Ala Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu
1345                1350                1355                1360
Gln Asn Met Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys
                1365                1370                1375    
Tyr Val Thr Ala Ile Ser Ile Tyr Lys Gly Tyr Cys Leu Ile Ser Phe
            1380                1385                1390        
Leu Arg Leu Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala Ala
        1395                1400                1405            
Glu Ala Leu Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala
    1410                1415                1420                
Val Ile Ala Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys
1425                1430                1435                1440
Gln Trp Arg Ser Glu Val Asp Glu Lys Arg Gln Val Phe His Ala Leu
                1445                1450                1455    
Glu Asp Glu Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe Lys
            1460                1465                1470        
Thr Tyr Lys Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys Ala
        1475                1480                1485            
Asp Gln Leu Val Glu Arg Trp Gln Asn Val His Val Gln Ile Asp Asn
    1490                1495                1500                
Arg Leu Arg Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg
1505                1510                1515                1520
Asp Thr Tyr His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr Thr
                1525                1530                1535    
Gln Arg Lys Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala
            1540                1545                1550        
Thr Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met Lys
        1555                1560                1565            
Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala
    1570                1575                1580                
Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met Val
1585                1590                1595                1600
Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser Ser
                1605                1610                1615    
Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr
            1620                1625                1630        
Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser
        1635                1640                1645            
Leu Lys Arg Leu Glu Glu Glu Glu Val Ile Ile Asn Ser Glu His Pro
    1650                1655                1660                
Val Asn Ile Lys Glu Leu Glu Ile Lys Arg Cys Lys Glu Thr Ser Glu
1665                1670                1675                1680
His Gly Ala Tyr Ser Asp Leu Leu Gln Arg Gln Lys Ala Thr Val Leu
                1685                1690                1695    
Glu Asn Ser Lys Leu Thr Gly Lys Ile Ser Glu Leu Glu Arg Met Val
            1700                1705                1710        
Ala Glu Leu Lys Lys Gln Lys Ser Arg Val Glu Glu Glu Leu Pro Lys
        1715                1720                1725            
Val Arg Glu Ala Ala Glu Asn Glu Leu Arg Lys Gln Gln Arg Asn Val
    1730                1735                1740                
Glu Asp Ile Ser Leu Gln Lys Ile Arg Ala Glu Ser Glu Ala Lys Gln
1745                1750                1755                1760
Tyr Arg Arg Glu Leu Glu Thr Ile Val Arg Glu Lys Glu Ala Ala Glu
                1765                1770                1775    
Arg Glu Leu Glu Arg Val Arg Gln Leu Thr Ile Glu Ala Glu Ala Lys
            1780                1785                1790        
Arg Ala Ala Val Glu Glu Asn Leu Leu Asn Phe Arg Asn Gln Leu Glu
        1795                1800                1805            
Glu Asn Thr Phe Thr Arg Arg Thr Leu Glu Asp His Leu Lys Arg Lys
    1810                1815                1820                
Asp Leu Ser Leu Asn Asp Leu Glu Gln Gln Lys Asn Lys Leu Met Glu
1825                1830                1835                1840
Glu Leu Arg Arg Lys Arg Asp Asn Glu Glu Glu Leu Leu Lys Leu Ile
                1845                1850                1855    
Lys Gln Met Glu Lys Asp Leu Ala Phe Gln Lys Gln Val Ala Glu Lys
            1860                1865                1870        
Gln Leu Lys Glu Lys Gln Lys Ile Glu Leu Glu Ala Arg Arg Lys Ile
        1875                1880                1885            
Thr Glu Ile Gln Tyr Thr Cys Arg Glu Asn Ala Leu Pro Val Cys Pro
    1890                1895                1900                
Ile Thr Gln Ala Thr Ser Cys Arg Ala Val Thr Gly Leu Gln Gln Glu
1905                1910                1915                1920
His Asp Lys Gln Lys Ala Glu Glu Leu Lys Gln Gln Val Asp Glu Leu
                1925                1930                1935    
Thr Ala Ala Asn Arg Lys Ala Glu Gln Asp Met Arg Glu Leu Thr Tyr
            1940                1945                1950        
Glu Leu Asn Ala Leu Gln Leu Glu Lys Thr Ser Ser Glu Glu Lys Ala
        1955                1960                1965            
Arg Leu Leu Lys Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg Cys
    1970                1975                1980                
Leu Lys Leu Glu Leu Glu Arg Lys Asp Gln Ala Glu Lys Gly Tyr Ser
1985                1990                1995                2000
Gln Gln Leu Arg Glu Leu Gly Arg Gln Leu Asn Gln Thr Thr Gly Lys
                2005                2010                2015    
Ala Glu Glu Ala Met Gln Glu Ala Ser Asp Leu Lys Lys Ile Lys Arg
            2020                2025                2030        
Asn Tyr Gln Leu Glu Leu Glu Ser Leu Asn His Glu Lys Gly Lys Leu
        2035                2040                2045            
Gln Arg Glu Val Asp Arg Ile Thr Arg Ala His Ala Val Ala Glu Lys
    2050                2055                2060                
Asn Ile Gln His Leu Asn Ser Gln Ile His Ser Phe Arg Asp Glu Lys
2065                2070                2075                2080
Glu Leu Glu Arg Leu Gln Ile Cys Gln Arg Lys Ser Asp His Leu Lys
                2085                2090                2095    
Glu Gln Phe Glu Lys Ser His Glu Gln Leu Leu Gln Asn Ile Lys Ala
            2100                2105                2110        
Glu Lys Glu Asn Asn Asp Lys Ile Gln Arg Leu Asn Glu Glu Leu Glu
        2115                2120                2125            
Lys Ser Asn Glu Cys Ala Glu Met Leu Lys Gln Lys Val Glu Glu Leu
    2130                2135                2140                
Thr Arg Gln Asn Asn Glu Thr Lys Leu Met Met Gln Arg Ile Gln Ala
2145                2150                2155                2160
Glu Ser Glu Asn Ile Val Leu Glu Lys Gln Thr Ile Gln Gln Arg Cys
                2165                2170                2175    
Glu Ala Leu Lys Ile Gln Ala Asp Gly Phe Lys Asp Gln Leu Arg Ser
            2180                2185                2190        
Thr Asn Glu His Leu His Lys Gln Thr Lys Thr Glu Gln Asp Phe Gln
        2195                2200                2205            
Arg Lys Ile Lys Cys Leu Glu Glu Asp Leu Ala Lys Ser Gln Asn Leu
    2210                2215                2220                
Val Ser Glu Phe Lys Gln Lys Cys Asp Gln Gln Asn Ile Ile Ile Gln
2225                2230                2235                2240
Asn Thr Lys Lys Glu Val Arg Asn Leu Asn Ala Glu Leu Asn Ala Ser
                2245                2250                2255    
Lys Glu Glu Lys Arg Arg Gly Glu Gln Lys Val Gln Leu Gln Gln Ala
            2260                2265                2270        
Gln Val Gln Glu Leu Asn Asn Arg Leu Lys Lys Val Gln Asp Glu Leu
        2275                2280                2285            
His Leu Lys Thr Ile Glu Glu Gln Met Thr His Arg Lys Met Val Leu
    2290                2295                2300                
Phe Gln Glu Glu Ser Gly Lys Phe Lys Gln Ser Ala Glu Glu Phe Arg
2305                2310                2315                2320
Lys Lys Met Glu Lys Leu Met Glu Ser Lys Val Ile Thr Glu Asn Asp
                2325                2330                2335    
Ile Ser Gly Ile Arg Leu Asp Phe Val Ser Leu Gln Gln Glu Asn Ser
            2340                2345                2350        
Arg Ala Gln Glu Asn Ala Lys Leu Cys Glu Thr Asn Ile Lys Glu Leu
        2355                2360                2365            
Glu Arg Gln Leu Gln Gln Tyr Arg Glu Gln Met Gln Gln Gly Gln His
    2370                2375                2380                
Met Glu Ala Asn His Tyr Gln Lys Cys Gln Lys Leu Glu Asp Glu Leu
2385                2390                2395                2400
Ile Ala Gln Lys Arg Glu Val Glu Asn Leu Lys Gln Lys Met Asp Gln
                2405                2410                2415    
Gln Ile Lys Glu His Glu His Gln Leu Val Leu Leu Gln Cys Glu Ile
            2420                2425                2430        
Gln Lys Lys Ser Thr Ala Lys Asp Cys Thr Phe Lys Pro Asp Phe Glu
        2435                2440                2445            
Met Thr Val Lys Glu Cys Gln His Ser Gly Glu Leu Ser Ser Arg Asn
    2450                2455                2460                
Thr Gly His Leu His Pro Thr Pro Arg Ser Pro Leu Leu Arg Trp Thr
2465                2470                2475                2480
Gln Glu Pro Gln Pro Leu Glu Glu Lys Trp Gln His Arg Val Val Glu
                2485                2490                2495    
Gln Ile Pro Lys Glu Val Gln Phe Gln Pro Pro Gly Ala Pro Leu Glu
            2500                2505                2510        
Lys Glu Lys Ser Gln Gln Cys Tyr Ser Glu Tyr Phe Ser Gln Thr Ser
        2515                2520                2525            
Thr Glu Leu Gln Ile Thr Phe Asp Glu Thr Asn Pro Ile Thr Arg Leu
    2530                2535                2540                
Ser Glu Ile Glu Lys Ile Arg Asp Gln Ala Leu Asn Asn Ser Arg Pro
2545                2550                2555                2560
Pro Val Arg Tyr Gln Asp Asn Ala Cys Glu Met Glu Leu Val Lys Val
                2565                2570                2575    
Leu Thr Pro Leu Glu Val Tyr Ser Val Phe
            2580                2585    


<210> 8416
<211> 2649
<212> PRT
<213> Homo sapiens

<400> 8416
Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser
 1               5                  10                  15      
Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu
            20                  25                  30          
Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly
        35                  40                  45              
Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala
    50                  55                  60                  
Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu
65                  70                  75                  80  
Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val
                85                  90                  95      
Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu
            100                 105                 110         
Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly
        115                 120                 125             
Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg
    130                 135                 140                 
Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys
145                 150                 155                 160 
Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile
                165                 170                 175     
Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu
            180                 185                 190         
Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser
        195                 200                 205             
Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser
    210                 215                 220                 
Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn
225                 230                 235                 240 
Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met
                245                 250                 255     
Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu
            260                 265                 270         
Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp
        275                 280                 285             
Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp
    290                 295                 300                 
Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg
305                 310                 315                 320 
Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu
                325                 330                 335     
Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His
            340                 345                 350         
Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln
        355                 360                 365             
Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn
    370                 375                 380                 
Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp
385                 390                 395                 400 
Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala
                405                 410                 415     
Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val
            420                 425                 430         
Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu
        435                 440                 445             
Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile
    450                 455                 460                 
Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala
465                 470                 475                 480 
Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg
                485                 490                 495     
Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser
            500                 505                 510         
Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys
        515                 520                 525             
Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys
    530                 535                 540                 
Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu
545                 550                 555                 560 
Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu
                565                 570                 575     
Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His
            580                 585                 590         
Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val
        595                 600                 605             
Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp
    610                 615                 620                 
Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp
625                 630                 635                 640 
His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu
                645                 650                 655     
Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys
            660                 665                 670         
Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser
        675                 680                 685             
Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser
    690                 695                 700                 
Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln
705                 710                 715                 720 
Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu
                725                 730                 735     
Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg
            740                 745                 750         
Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu
        755                 760                 765             
Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu
    770                 775                 780                 
Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile
785                 790                 795                 800 
Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser
                805                 810                 815     
Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn
            820                 825                 830         
Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val
        835                 840                 845             
Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu
    850                 855                 860                 
Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn
865                 870                 875                 880 
Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val
                885                 890                 895     
Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys
            900                 905                 910         
Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp
        915                 920                 925             
Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg
    930                 935                 940                 
Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu
945                 950                 955                 960 
Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu
                965                 970                 975     
Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu
            980                 985                 990         
Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala Thr Gln Leu Asn Gln Gln
        995                 1000                1005            
Lys Met Leu Val Ser Glu Ile Glu Met Lys Gln Ser Lys Met Asp Glu
    1010                1015                1020                
Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala Thr Val Lys Asp Tyr Glu
1025                1030                1035                1040
Leu Gln Thr Met Thr Tyr Arg Ala Met Val Asp Ser Gln Gln Lys Ser
                1045                1050                1055    
Pro Val Lys Arg Arg Arg Met Gln Ser Ser Ala Asp Leu Ile Ile Gln
            1060                1065                1070        
Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu Val Thr Leu Met
        1075                1080                1085            
Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser Leu Lys Arg Leu Glu Glu
    1090                1095                1100                
Glu Glu Ile Lys Arg Cys Lys Glu Thr Ser Glu His Gly Ala Tyr Ser
1105                1110                1115                1120
Asp Leu Leu Gln Arg Gln Lys Ala Thr Val Leu Glu Asn Ser Lys Leu
                1125                1130                1135    
Thr Gly Lys Ile Ser Glu Leu Glu Arg Met Val Ala Glu Leu Lys Lys
            1140                1145                1150        
Gln Lys Ser Arg Val Glu Glu Glu Leu Pro Lys Val Arg Glu Ala Ala
        1155                1160                1165            
Glu Asn Glu Leu Arg Lys Gln Gln Arg Asn Val Glu Asp Ile Ser Leu
    1170                1175                1180                
Gln Lys Ile Arg Ala Glu Ser Glu Ala Lys Gln Tyr Arg Arg Glu Leu
1185                1190                1195                1200
Glu Thr Ile Val Arg Glu Lys Glu Ala Ala Glu Arg Glu Leu Glu Arg
                1205                1210                1215    
Val Arg Gln Leu Thr Ile Glu Ala Glu Ala Lys Arg Ala Ala Val Glu
            1220                1225                1230        
Glu Asn Leu Leu Asn Phe Arg Asn Gln Leu Glu Glu Asn Thr Phe Thr
        1235                1240                1245            
Arg Arg Thr Leu Glu Asp His Leu Lys Arg Lys Asp Leu Ser Leu Asn
    1250                1255                1260                
Asp Leu Glu Gln Gln Lys Asn Lys Leu Met Glu Glu Leu Arg Arg Lys
1265                1270                1275                1280
Arg Asp Asn Glu Glu Glu Leu Leu Lys Leu Ile Lys Gln Met Glu Lys
                1285                1290                1295    
Asp Leu Ala Phe Gln Lys Gln Val Ala Glu Lys Gln Leu Lys Glu Lys
            1300                1305                1310        
Gln Lys Ile Glu Leu Glu Ala Arg Arg Lys Ile Thr Glu Ile Gln Tyr
        1315                1320                1325            
Thr Cys Arg Glu Asn Ala Leu Pro Val Cys Pro Ile Thr Gln Ala Thr
    1330                1335                1340                
Ser Cys Arg Ala Val Thr Gly Leu Gln Gln Glu His Asp Lys Gln Lys
1345                1350                1355                1360
Ala Glu Glu Leu Lys Gln Gln Val Asp Glu Leu Thr Ala Ala Asn Arg
                1365                1370                1375    
Lys Ala Glu Gln Asp Met Arg Glu Leu Thr Tyr Glu Leu Asn Ala Leu
            1380                1385                1390        
Gln Leu Glu Lys Thr Ser Ser Glu Glu Lys Ala Arg Leu Leu Lys Asp
        1395                1400                1405            
Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg Cys Leu Lys Leu Glu Leu
    1410                1415                1420                
Glu Arg Lys Asp Gln Ala Glu Lys Gly Tyr Ser Gln Gln Leu Arg Glu
1425                1430                1435                1440
Leu Gly Arg Gln Leu Asn Gln Thr Thr Gly Lys Ala Glu Glu Ala Met
                1445                1450                1455    
Gln Glu Ala Ser Asp Leu Lys Lys Ile Lys Arg Asn Tyr Gln Leu Glu
            1460                1465                1470        
Leu Glu Ser Leu Asn His Glu Lys Gly Lys Leu Gln Arg Glu Val Asp
        1475                1480                1485            
Arg Ile Thr Arg Ala His Ala Val Ala Glu Lys Asn Ile Gln His Leu
    1490                1495                1500                
Asn Ser Gln Ile His Ser Phe Arg Asp Glu Lys Glu Leu Glu Arg Leu
1505                1510                1515                1520
Gln Ile Cys Gln Arg Lys Ser Asp His Leu Lys Glu Gln Phe Glu Lys
                1525                1530                1535    
Ser His Glu Gln Leu Leu Gln Asn Ile Lys Ala Glu Lys Glu Asn Asn
            1540                1545                1550        
Asp Lys Ile Gln Arg Leu Asn Glu Glu Leu Glu Lys Ser Asn Glu Cys
        1555                1560                1565            
Ala Glu Met Leu Lys Gln Lys Val Glu Glu Leu Thr Arg Gln Asn Asn
    1570                1575                1580                
Glu Thr Lys Leu Met Met Gln Arg Ile Gln Ala Glu Ser Glu Asn Ile
1585                1590                1595                1600
Val Leu Glu Lys Gln Thr Ile Gln Gln Arg Cys Glu Ala Leu Lys Ile
                1605                1610                1615    
Gln Ala Asp Gly Phe Lys Asp Gln Leu Arg Ser Thr Asn Glu His Leu
            1620                1625                1630        
His Lys Gln Thr Lys Thr Glu Gln Asp Phe Gln Arg Lys Ile Lys Cys
        1635                1640                1645            
Leu Glu Glu Asp Leu Ala Lys Ser Gln Asn Leu Val Ser Glu Phe Lys
    1650                1655                1660                
Gln Lys Cys Asp Gln Gln Asn Ile Ile Ile Gln Asn Thr Lys Lys Glu
1665                1670                1675                1680
Val Arg Asn Leu Asn Ala Glu Leu Asn Ala Ser Lys Glu Glu Lys Arg
                1685                1690                1695    
Arg Gly Glu Gln Lys Val Gln Leu Gln Gln Ala Gln Val Gln Glu Leu
            1700                1705                1710        
Asn Asn Arg Leu Lys Lys Val Gln Asp Glu Leu His Leu Lys Thr Ile
        1715                1720                1725            
Glu Glu Gln Met Thr His Arg Lys Met Val Leu Phe Gln Glu Glu Ser
    1730                1735                1740                
Gly Lys Phe Lys Gln Ser Ala Glu Glu Phe Arg Lys Lys Met Glu Lys
1745                1750                1755                1760
Leu Met Glu Ser Lys Val Ile Thr Glu Asn Asp Ile Ser Gly Ile Arg
                1765                1770                1775    
Leu Asp Phe Val Ser Leu Gln Gln Glu Asn Ser Arg Ala Gln Glu Asn
            1780                1785                1790        
Ala Lys Leu Cys Glu Thr Asn Ile Lys Glu Leu Glu Arg Gln Leu Gln
        1795                1800                1805            
Gln Tyr Arg Glu Gln Met Gln Gln Gly Gln His Met Glu Ala Asn His
    1810                1815                1820                
Tyr Gln Lys Cys Gln Lys Leu Glu Asp Glu Leu Ile Ala Gln Lys Arg
1825                1830                1835                1840
Glu Val Glu Asn Leu Lys Gln Lys Met Asp Gln Gln Ile Lys Glu His
                1845                1850                1855    
Glu His Gln Leu Val Leu Leu Gln Cys Glu Ile Gln Lys Lys Ser Thr
            1860                1865                1870        
Ala Lys Asp Cys Thr Phe Lys Pro Asp Phe Glu Met Thr Val Lys Glu
        1875                1880                1885            
Cys Gln His Ser Gly Glu Leu Ser Ser Arg Asn Thr Gly His Leu His
    1890                1895                1900                
Pro Thr Pro Arg Ser Pro Leu Leu Arg Trp Thr Gln Glu Pro Gln Pro
1905                1910                1915                1920
Leu Glu Glu Lys Trp Gln His Arg Val Val Glu Gln Ile Pro Lys Glu
                1925                1930                1935    
Val Gln Phe Gln Pro Pro Gly Ala Pro Leu Glu Lys Glu Lys Ser Gln
            1940                1945                1950        
Gln Cys Tyr Ser Glu Tyr Phe Ser Gln Thr Ser Thr Glu Leu Gln Ile
        1955                1960                1965            
Thr Phe Asp Glu Thr Asn Pro Ile Thr Arg Leu Ser Glu Ile Glu Lys
    1970                1975                1980                
Ile Arg Asp Gln Ala Leu Asn Asn Ser Arg Pro Pro Val Arg Tyr Gln
1985                1990                1995                2000
Asp Asn Ala Cys Glu Met Glu Leu Val Lys Val Leu Thr Pro Leu Glu
                2005                2010                2015    
Ile Ala Lys Asn Lys Gln Tyr Asp Met His Thr Glu Val Thr Thr Leu
            2020                2025                2030        
Lys Gln Glu Lys Asn Pro Val Pro Ser Ala Glu Glu Trp Met Leu Glu
        2035                2040                2045            
Gly Cys Arg Ala Ser Gly Gly Leu Lys Lys Gly Asp Phe Leu Lys Lys
    2050                2055                2060                
Gly Leu Glu Pro Glu Thr Phe Gln Asn Phe Asp Gly Asp His Ala Cys
2065                2070                2075                2080
Ser Val Arg Asp Asp Glu Phe Lys Phe Gln Gly Leu Arg His Thr Val
                2085                2090                2095    
Thr Ala Arg Gln Leu Val Glu Ala Lys Leu Leu Asp Met Arg Thr Ile
            2100                2105                2110        
Glu Gln Leu Arg Leu Gly Leu Lys Thr Val Glu Glu Val Gln Lys Thr
        2115                2120                2125            
Leu Asn Lys Phe Leu Thr Lys Ala Thr Ser Ile Ala Gly Leu Tyr Leu
    2130                2135                2140                
Glu Ser Thr Lys Glu Lys Ile Ser Phe Ala Ser Ala Ala Glu Arg Ile
2145                2150                2155                2160
Ile Ile Asp Lys Met Val Ala Leu Ala Phe Leu Glu Ala Gln Ala Ala
                2165                2170                2175    
Thr Gly Phe Ile Ile Asp Pro Ile Ser Gly Gln Thr Tyr Ser Val Glu
            2180                2185                2190        
Asp Ala Val Leu Lys Gly Val Val Asp Pro Glu Phe Arg Ile Arg Leu
        2195                2200                2205            
Leu Glu Ala Glu Lys Ala Ala Val Gly Tyr Ser Tyr Ser Ser Lys Thr
    2210                2215                2220                
Leu Ser Val Phe Gln Ala Met Glu Asn Arg Met Leu Asp Arg Gln Lys
2225                2230                2235                2240
Gly Lys His Ile Leu Glu Ala Gln Ile Ala Ser Gly Gly Val Ile Asp
                2245                2250                2255    
Pro Val Arg Gly Ile Arg Val Pro Pro Glu Ile Ala Leu Gln Gln Gly
            2260                2265                2270        
Leu Leu Asn Asn Ala Ile Leu Gln Phe Leu His Glu Pro Ser Ser Asn
        2275                2280                2285            
Thr Arg Val Phe Pro Asn Pro Asn Asn Lys Gln Ala Leu Tyr Tyr Ser
    2290                2295                2300                
Glu Leu Leu Arg Met Cys Val Phe Asp Val Glu Ser Gln Cys Phe Leu
2305                2310                2315                2320
Phe Pro Phe Gly Glu Arg Asn Ile Ser Asn Leu Asn Val Lys Lys Thr
                2325                2330                2335    
His Arg Ile Ser Val Val Asp Thr Lys Thr Gly Ser Glu Leu Thr Val
            2340                2345                2350        
Tyr Glu Ala Phe Gln Arg Asn Leu Ile Glu Lys Ser Ile Tyr Leu Glu
        2355                2360                2365            
Leu Ser Gly Gln Gln Tyr Gln Trp Lys Glu Ala Met Phe Phe Glu Ser
    2370                2375                2380                
Tyr Gly His Ser Ser His Met Leu Thr Asp Thr Lys Thr Gly Leu His
2385                2390                2395                2400
Phe Asn Ile Asn Glu Ala Ile Glu Gln Gly Thr Ile Asp Lys Ala Leu
                2405                2410                2415    
Val Lys Lys Tyr Gln Glu Gly Leu Ile Thr Leu Thr Glu Leu Ala Asp
            2420                2425                2430        
Ser Leu Leu Ser Arg Leu Val Pro Lys Lys Asp Leu His Ser Pro Val
        2435                2440                2445            
Ala Gly Tyr Trp Leu Thr Ala Ser Gly Glu Arg Ile Ser Val Leu Lys
    2450                2455                2460                
Ala Ser Arg Arg Asn Leu Val Asp Arg Ile Thr Ala Leu Arg Cys Leu
2465                2470                2475                2480
Glu Ala Gln Val Ser Thr Gly Gly Ile Ile Asp Pro Leu Thr Gly Lys
                2485                2490                2495    
Lys Tyr Arg Val Ala Glu Ala Leu His Arg Gly Leu Val Asp Glu Gly
            2500                2505                2510        
Phe Ala Gln Gln Leu Arg Gln Cys Glu Leu Val Ile Thr Gly Ile Gly
        2515                2520                2525            
His Pro Ile Thr Asn Lys Met Met Ser Val Val Glu Ala Val Asn Ala
    2530                2535                2540                
Asn Ile Ile Asn Lys Glu Met Gly Ile Arg Cys Leu Glu Phe Gln Tyr
2545                2550                2555                2560
Leu Thr Gly Gly Leu Ile Glu Pro Gln Val His Ser Arg Leu Ser Ile
                2565                2570                2575    
Glu Glu Ala Leu Gln Val Gly Ile Ile Asp Val Leu Ile Ala Thr Lys
            2580                2585                2590        
Leu Lys Asp Gln Lys Ser Tyr Val Arg Asn Ile Ile Cys Pro Gln Thr
        2595                2600                2605            
Lys Arg Lys Leu Thr Tyr Lys Glu Ala Leu Glu Lys Ala Asp Phe Asp
    2610                2615                2620                
Phe His Thr Gly Leu Lys Leu Leu Glu Val Ser Glu Pro Leu Met Thr
2625                2630                2635                2640
Gly Ile Ser Ser Leu Tyr Tyr Ser Ser
                2645                


<210> 8417
<211> 3030
<212> PRT
<213> Homo sapiens

<400> 8417
Met Ala Gly Tyr Leu Ser Pro Ala Ala Tyr Leu Tyr Val Glu Glu Gln
 1               5                  10                  15      
Glu Tyr Leu Gln Ala Tyr Glu Asp Val Leu Glu Arg Tyr Lys Asp Glu
            20                  25                  30          
Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln His
        35                  40                  45              
Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu Arg
    50                  55                  60                  
Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Thr
65                  70                  75                  80  
Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val
                85                  90                  95      
Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn
            100                 105                 110         
Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly
        115                 120                 125             
Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val
    130                 135                 140                 
Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp
145                 150                 155                 160 
Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe
                165                 170                 175     
Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys
            180                 185                 190         
Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn
        195                 200                 205             
Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val
    210                 215                 220                 
Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu
225                 230                 235                 240 
Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys
                245                 250                 255     
Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys
            260                 265                 270         
Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg
        275                 280                 285             
His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val
    290                 295                 300                 
Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu
305                 310                 315                 320 
Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys
                325                 330                 335     
Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu Gln Gly
            340                 345                 350         
Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile Ile Ala
        355                 360                 365             
Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg Leu Glu
    370                 375                 380                 
Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val Ile Cys
385                 390                 395                 400 
Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys
                405                 410                 415     
Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly
            420                 425                 430         
Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile Asp Val
        435                 440                 445             
Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln
    450                 455                 460                 
Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn Glu Cys
465                 470                 475                 480 
Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys
                485                 490                 495     
Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln
            500                 505                 510         
Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro
        515                 520                 525             
Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly Met Thr
    530                 535                 540                 
Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro
545                 550                 555                 560 
Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn Ser Leu
                565                 570                 575     
Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser
            580                 585                 590         
Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys Phe Val
        595                 600                 605             
Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu Asp Arg
    610                 615                 620                 
Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu Glu Asn
625                 630                 635                 640 
His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys
                645                 650                 655     
Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys Leu Thr
            660                 665                 670         
Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu
        675                 680                 685             
Phe Ser Leu Leu Lys Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp
    690                 695                 700                 
Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu
705                 710                 715                 720 
Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn
                725                 730                 735     
Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu
            740                 745                 750         
Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu
        755                 760                 765             
Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu Thr Ile Glu Val Lys
    770                 775                 780                 
Leu Glu Ser Val Met Val Leu Val Glu Tyr Ala Tyr Arg Ala Ala Met
785                 790                 795                 800 
Gln Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu Gln
                805                 810                 815     
His Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys
            820                 825                 830         
Glu Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp Ala Ile Gln Arg Lys
        835                 840                 845             
Tyr Ser Cys Asp Arg Ser Ser Ser Ile His Lys Leu Glu Asp Leu Val
    850                 855                 860                 
Gln Glu Ser Met Glu Glu Lys Glu Glu Leu Leu Gln Tyr Lys Ser Thr
865                 870                 875                 880 
Ile Ala Asn Leu Met Gly Lys Ala Lys Thr Ile Ile Gln Leu Lys Pro
                885                 890                 895     
Arg Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile Pro Ile Lys Ala Ile
            900                 905                 910         
Cys Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr Lys Asp Asp Glu Cys
        915                 920                 925             
Val Leu Ala Asn Asn Ser His Arg Ala Lys Trp Lys Val Ile Ser Pro
    930                 935                 940                 
Thr Gly Asn Glu Ala Met Val Pro Ser Val Cys Phe Thr Val Pro Pro
945                 950                 955                 960 
Pro Asn Lys Glu Ala Val Asp Leu Ala Asn Arg Ile Glu Gln Gln Tyr
                965                 970                 975     
Gln Asn Val Leu Thr Leu Trp His Glu Ser His Ile Asn Met Lys Ser
            980                 985                 990         
Val Val Ser Trp His Tyr Leu Ile Asn Glu Ile Asp Arg Ile Arg Ala
        995                 1000                1005            
Ser Asn Val Ala Ser Val Ser Met Asn Leu Ile Lys Thr Met Leu Pro
    1010                1015                1020                
Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser Arg Phe Glu Asp
1025                1030                1035                1040
Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser Gly Ser Asp Ile
                1045                1050                1055    
Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln Tyr Tyr Gln Glu
            1060                1065                1070        
Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu Ser Val Tyr Asn
        1075                1080                1085            
Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg Leu Glu Asn Cys
    1090                1095                1100                
Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu Glu Arg Asp Asp
1105                1110                1115                1120
Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu Lys Leu Lys Lys
                1125                1130                1135    
Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile Thr Asn Lys Cys
            1140                1145                1150        
Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser Val Pro Thr Leu
        1155                1160                1165            
Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn Gln Val Tyr Ser
    1170                1175                1180                
Met Ser Ser Thr Tyr Ile Asp Lys Tyr Val Thr Ala Ile Ser Ile Tyr
1185                1190                1195                1200
Lys Gly Tyr Cys Leu Ile Ser Phe Leu Arg Leu Lys Thr Val Asn Leu
                1205                1210                1215    
Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu Tyr Glu
            1220                1225                1230        
Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn Asn Ile
        1235                1240                1245            
Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val Asp Glu
    1250                1255                1260                
Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys Ala Lys
1265                1270                1275                1280
Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp Leu Asp
                1285                1290                1295    
Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg Trp Gln
            1300                1305                1310        
Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu Gly Ile
        1315                1320                1325            
Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu Asp Asp
    1330                1335                1340                
Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu Asn Gln
1345                1350                1355                1360
Pro Glu Asn Ser Lys Thr Leu Ala Thr Gln Leu Asn Gln Gln Lys Met
                1365                1370                1375    
Leu Val Ser Glu Ile Glu Met Lys Gln Ser Lys Met Asp Glu Cys Gln
            1380                1385                1390        
Lys Tyr Ala Glu Gln Tyr Ser Ala Thr Val Lys Asp Tyr Glu Leu Gln
        1395                1400                1405            
Thr Met Thr Tyr Arg Ala Met Val Asp Ser Gln Gln Lys Ser Pro Val
    1410                1415                1420                
Lys Arg Arg Arg Met Gln Ser Ser Ala Asp Leu Ile Ile Gln Glu Phe
1425                1430                1435                1440
Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu Val Thr Leu Met Thr Gln
                1445                1450                1455    
Tyr Ile Lys Phe Ala Gly Asp Ser Leu Lys Arg Leu Glu Glu Glu Glu
            1460                1465                1470        
Val Ile Ile Asn Ser Glu His Pro Val Asn Ile Lys Glu Leu Glu Ile
        1475                1480                1485            
Lys Arg Cys Lys Glu Thr Ser Glu His Gly Ala Tyr Ser Asp Leu Leu
    1490                1495                1500                
Gln Arg Gln Lys Ala Thr Val Leu Glu Asn Ser Lys Leu Thr Gly Lys
1505                1510                1515                1520
Ile Ser Glu Leu Glu Arg Met Val Ala Glu Leu Lys Lys Gln Lys Ser
                1525                1530                1535    
Arg Val Glu Glu Glu Leu Pro Lys Val Arg Glu Ala Ala Glu Asn Glu
            1540                1545                1550        
Leu Arg Lys Gln Gln Arg Asn Val Glu Asp Ile Ser Leu Gln Lys Ile
        1555                1560                1565            
Arg Ala Glu Ser Glu Ala Lys Gln Tyr Arg Arg Glu Leu Glu Thr Ile
    1570                1575                1580                
Val Arg Glu Lys Glu Ala Ala Glu Arg Glu Leu Glu Arg Val Arg Gln
1585                1590                1595                1600
Leu Thr Ile Glu Ala Glu Ala Lys Arg Ala Ala Val Glu Glu Asn Leu
                1605                1610                1615    
Leu Asn Phe Arg Asn Gln Leu Glu Glu Asn Thr Phe Thr Arg Arg Thr
            1620                1625                1630        
Leu Glu Asp His Leu Lys Arg Lys Asp Leu Ser Leu Asn Asp Leu Glu
        1635                1640                1645            
Gln Gln Lys Asn Lys Leu Met Glu Glu Leu Arg Arg Lys Arg Asp Asn
    1650                1655                1660                
Glu Glu Glu Leu Leu Lys Leu Ile Lys Gln Met Glu Lys Asp Leu Ala
1665                1670                1675                1680
Phe Gln Lys Gln Val Ala Glu Lys Gln Leu Lys Glu Lys Gln Lys Ile
                1685                1690                1695    
Glu Leu Glu Ala Arg Arg Lys Ile Thr Glu Ile Gln Tyr Thr Cys Arg
            1700                1705                1710        
Glu Asn Ala Leu Pro Val Cys Pro Ile Thr Gln Ala Thr Ser Cys Arg
        1715                1720                1725            
Ala Val Thr Gly Leu Gln Gln Glu His Asp Lys Gln Lys Ala Glu Glu
    1730                1735                1740                
Leu Lys Gln Gln Val Asp Glu Leu Thr Ala Ala Asn Arg Lys Ala Glu
1745                1750                1755                1760
Gln Asp Met Arg Glu Leu Thr Tyr Glu Leu Asn Ala Leu Gln Leu Glu
                1765                1770                1775    
Lys Thr Ser Ser Glu Glu Lys Ala Arg Leu Leu Lys Asp Lys Leu Asp
            1780                1785                1790        
Glu Thr Asn Asn Thr Leu Arg Cys Leu Lys Leu Glu Leu Glu Arg Lys
        1795                1800                1805            
Asp Gln Ala Glu Lys Gly Tyr Ser Gln Gln Leu Arg Glu Leu Gly Arg
    1810                1815                1820                
Gln Leu Asn Gln Thr Thr Gly Lys Ala Glu Glu Ala Met Gln Glu Ala
1825                1830                1835                1840
Ser Asp Leu Lys Lys Ile Lys Arg Asn Tyr Gln Leu Glu Leu Glu Ser
                1845                1850                1855    
Leu Asn His Glu Lys Gly Lys Leu Gln Arg Glu Val Asp Arg Ile Thr
            1860                1865                1870        
Arg Ala His Ala Val Ala Glu Lys Asn Ile Gln His Leu Asn Ser Gln
        1875                1880                1885            
Ile His Ser Phe Arg Asp Glu Lys Glu Leu Glu Arg Leu Gln Ile Cys
    1890                1895                1900                
Gln Arg Lys Ser Asp His Leu Lys Glu Gln Phe Glu Lys Ser His Glu
1905                1910                1915                1920
Gln Leu Leu Gln Asn Ile Lys Ala Glu Lys Glu Asn Asn Asp Lys Ile
                1925                1930                1935    
Gln Arg Leu Asn Glu Glu Leu Glu Lys Ser Asn Glu Cys Ala Glu Met
            1940                1945                1950        
Leu Lys Gln Lys Val Glu Glu Leu Thr Arg Gln Asn Asn Glu Thr Lys
        1955                1960                1965            
Leu Met Met Gln Arg Ile Gln Ala Glu Ser Glu Asn Ile Val Leu Glu
    1970                1975                1980                
Lys Gln Thr Ile Gln Gln Arg Cys Glu Ala Leu Lys Ile Gln Ala Asp
1985                1990                1995                2000
Gly Phe Lys Asp Gln Leu Arg Ser Thr Asn Glu His Leu His Lys Gln
                2005                2010                2015    
Thr Lys Thr Glu Gln Asp Phe Gln Arg Lys Ile Lys Cys Leu Glu Glu
            2020                2025                2030        
Asp Leu Ala Lys Ser Gln Asn Leu Val Ser Glu Phe Lys Gln Lys Cys
        2035                2040                2045            
Asp Gln Gln Asn Ile Ile Ile Gln Asn Thr Lys Lys Glu Val Arg Asn
    2050                2055                2060                
Leu Asn Ala Glu Leu Asn Ala Ser Lys Glu Glu Lys Arg Arg Gly Glu
2065                2070                2075                2080
Gln Lys Val Gln Leu Gln Gln Ala Gln Val Gln Glu Leu Asn Asn Arg
                2085                2090                2095    
Leu Lys Lys Val Gln Asp Glu Leu His Leu Lys Thr Ile Glu Glu Gln
            2100                2105                2110        
Met Thr His Arg Lys Met Val Leu Phe Gln Glu Glu Ser Gly Lys Phe
        2115                2120                2125            
Lys Gln Ser Ala Glu Glu Phe Arg Lys Lys Met Glu Lys Leu Met Glu
    2130                2135                2140                
Ser Lys Val Ile Thr Glu Asn Asp Ile Ser Gly Ile Arg Leu Asp Phe
2145                2150                2155                2160
Val Ser Leu Gln Gln Glu Asn Ser Arg Ala Gln Glu Asn Ala Lys Leu
                2165                2170                2175    
Cys Glu Thr Asn Ile Lys Glu Leu Glu Arg Gln Leu Gln Gln Tyr Arg
            2180                2185                2190        
Glu Gln Met Gln Gln Gly Gln His Met Glu Ala Asn His Tyr Gln Lys
        2195                2200                2205            
Cys Gln Lys Leu Glu Asp Glu Leu Ile Ala Gln Lys Arg Glu Val Glu
    2210                2215                2220                
Asn Leu Lys Gln Lys Met Asp Gln Gln Ile Lys Glu His Glu His Gln
2225                2230                2235                2240
Leu Val Leu Leu Gln Cys Glu Ile Gln Lys Lys Ser Thr Ala Lys Asp
                2245                2250                2255    
Cys Thr Phe Lys Pro Asp Phe Glu Met Thr Val Lys Glu Cys Gln His
            2260                2265                2270        
Ser Gly Glu Leu Ser Ser Arg Asn Thr Gly His Leu His Pro Thr Pro
        2275                2280                2285            
Arg Ser Pro Leu Leu Arg Trp Thr Gln Glu Pro Gln Pro Leu Glu Glu
    2290                2295                2300                
Lys Trp Gln His Arg Val Val Glu Gln Ile Pro Lys Glu Val Gln Phe
2305                2310                2315                2320
Gln Pro Pro Gly Ala Pro Leu Glu Lys Glu Lys Ser Gln Gln Cys Tyr
                2325                2330                2335    
Ser Glu Tyr Phe Ser Gln Thr Ser Thr Glu Leu Gln Ile Thr Phe Asp
            2340                2345                2350        
Glu Thr Asn Pro Ile Thr Arg Leu Ser Glu Ile Glu Lys Ile Arg Asp
        2355                2360                2365            
Gln Ala Leu Asn Asn Ser Arg Pro Pro Val Arg Tyr Gln Asp Asn Ala
    2370                2375                2380                
Cys Glu Met Glu Leu Val Lys Val Leu Thr Pro Leu Glu Ile Ala Lys
2385                2390                2395                2400
Asn Lys Gln Tyr Asp Met His Thr Glu Val Thr Thr Leu Lys Gln Glu
                2405                2410                2415    
Lys Asn Pro Val Pro Ser Ala Glu Glu Trp Met Leu Glu Gly Cys Arg
            2420                2425                2430        
Ala Ser Gly Gly Leu Lys Lys Gly Asp Phe Leu Lys Lys Gly Leu Glu
        2435                2440                2445            
Pro Glu Thr Phe Gln Asn Phe Asp Gly Asp His Ala Cys Ser Val Arg
    2450                2455                2460                
Asp Asp Glu Phe Lys Phe Gln Gly Leu Arg His Thr Val Thr Ala Arg
2465                2470                2475                2480
Gln Leu Val Glu Ala Lys Leu Leu Asp Met Arg Thr Ile Glu Gln Leu
                2485                2490                2495    
Arg Leu Gly Leu Lys Thr Val Glu Glu Val Gln Lys Thr Leu Asn Lys
            2500                2505                2510        
Phe Leu Thr Lys Ala Thr Ser Ile Ala Gly Leu Tyr Leu Glu Ser Thr
        2515                2520                2525            
Lys Glu Lys Ile Ser Phe Ala Ser Ala Ala Glu Arg Ile Ile Ile Asp
    2530                2535                2540                
Lys Met Val Ala Leu Ala Phe Leu Glu Ala Gln Ala Ala Thr Gly Phe
2545                2550                2555                2560
Ile Ile Asp Pro Ile Ser Gly Gln Thr Tyr Ser Val Glu Asp Ala Val
                2565                2570                2575    
Leu Lys Gly Val Val Asp Pro Glu Phe Arg Ile Arg Leu Leu Glu Ala
            2580                2585                2590        
Glu Lys Ala Ala Val Gly Tyr Ser Tyr Ser Ser Lys Thr Leu Ser Val
        2595                2600                2605            
Phe Gln Ala Met Glu Asn Arg Met Leu Asp Arg Gln Lys Gly Lys His
    2610                2615                2620                
Ile Leu Glu Ala Gln Ile Ala Ser Gly Gly Val Ile Asp Pro Val Arg
2625                2630                2635                2640
Gly Ile Arg Val Pro Pro Glu Ile Ala Leu Gln Gln Gly Leu Leu Asn
                2645                2650                2655    
Asn Ala Ile Leu Gln Phe Leu His Glu Pro Ser Ser Asn Thr Arg Val
            2660                2665                2670        
Phe Pro Asn Pro Asn Asn Lys Gln Ala Leu Tyr Tyr Ser Glu Leu Leu
        2675                2680                2685            
Arg Met Cys Val Phe Asp Val Glu Ser Gln Cys Phe Leu Phe Pro Phe
    2690                2695                2700                
Gly Glu Arg Asn Ile Ser Asn Leu Asn Val Lys Lys Thr His Arg Ile
2705                2710                2715                2720
Ser Val Val Asp Thr Lys Thr Gly Ser Glu Leu Thr Val Tyr Glu Ala
                2725                2730                2735    
Phe Gln Arg Asn Leu Ile Glu Lys Ser Ile Tyr Leu Glu Leu Ser Gly
            2740                2745                2750        
Gln Gln Tyr Gln Trp Lys Glu Ala Met Phe Phe Glu Ser Tyr Gly His
        2755                2760                2765            
Ser Ser His Met Leu Thr Asp Thr Lys Thr Gly Leu His Phe Asn Ile
    2770                2775                2780                
Asn Glu Ala Ile Glu Gln Gly Thr Ile Asp Lys Ala Leu Val Lys Lys
2785                2790                2795                2800
Tyr Gln Glu Gly Leu Ile Thr Leu Thr Glu Leu Ala Asp Ser Leu Leu
                2805                2810                2815    
Ser Arg Leu Val Pro Lys Lys Asp Leu His Ser Pro Val Ala Gly Tyr
            2820                2825                2830        
Trp Leu Thr Ala Ser Gly Glu Arg Ile Ser Val Leu Lys Ala Ser Arg
        2835                2840                2845            
Arg Asn Leu Val Asp Arg Ile Thr Ala Leu Arg Cys Leu Glu Ala Gln
    2850                2855                2860                
Val Ser Thr Gly Gly Ile Ile Asp Pro Leu Thr Gly Lys Lys Tyr Arg
2865                2870                2875                2880
Val Ala Glu Ala Leu His Arg Gly Leu Val Asp Glu Gly Phe Ala Gln
                2885                2890                2895    
Gln Leu Arg Gln Cys Glu Leu Val Ile Thr Gly Ile Gly His Pro Ile
            2900                2905                2910        
Thr Asn Lys Met Met Ser Val Val Glu Ala Val Asn Ala Asn Ile Ile
        2915                2920                2925            
Asn Lys Glu Met Gly Ile Arg Cys Leu Glu Phe Gln Tyr Leu Thr Gly
    2930                2935                2940                
Gly Leu Ile Glu Pro Gln Val His Ser Arg Leu Ser Ile Glu Glu Ala
2945                2950                2955                2960
Leu Gln Val Gly Ile Ile Asp Val Leu Ile Ala Thr Lys Leu Lys Asp
                2965                2970                2975    
Gln Lys Ser Tyr Val Arg Asn Ile Ile Cys Pro Gln Thr Lys Arg Lys
            2980                2985                2990        
Leu Thr Tyr Lys Glu Ala Leu Glu Lys Ala Asp Phe Asp Phe His Thr
        2995                3000                3005            
Gly Leu Lys Leu Leu Glu Val Ser Glu Pro Leu Met Thr Gly Ile Ser
    3010                3015                3020                
Ser Leu Tyr Tyr Ser Ser
3025                3030


<210> 8418
<211> 3222
<212> PRT
<213> Homo sapiens

<400> 8418
Pro Ser Pro Arg Pro His His Asp Arg Arg Gly Phe Pro Arg Leu Ala
 1               5                  10                  15      
Glu Thr Leu Gln His Pro Met Cys Pro Leu Pro Leu Val Ala Ser Ala
            20                  25                  30          
Gly His His Arg His His Arg Leu Leu Leu Leu Leu Ala Pro Gln Ala
        35                  40                  45              
Pro Glu Arg Glu Ala Ser Asp Glu Ile Phe Ser Gly Arg Ser Arg Ser
    50                  55                  60                  
Arg Asp Ala Val Leu Arg Ser His His Phe Arg Ser Glu Gly Phe Arg
65                  70                  75                  80  
Ala Ser Pro Arg His Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala
                85                  90                  95      
Arg Leu Glu Glu Val Lys Pro Val Val Glu Val His His Gln Ser Glu
            100                 105                 110         
Gln Glu Thr Ser Val Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val
        115                 120                 125             
Gln Pro Glu Phe Tyr His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro
    130                 135                 140                 
Ser Ser Gly Asn Ala Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp
145                 150                 155                 160 
Phe Ser Asp Glu Asp Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro
                165                 170                 175     
Ala Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser
            180                 185                 190         
Lys Arg Lys Ile Gln Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala
        195                 200                 205             
Val Leu Arg Ile Ala Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe
    210                 215                 220                 
Thr Lys Trp Ile Asn Gln His Leu Met Lys Val Arg Lys His Val Asn
225                 230                 235                 240 
Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu
                245                 250                 255     
Glu Val Leu Ser Gly Asp Thr Leu Pro Arg Glu Lys Gly Arg Met Arg
            260                 265                 270         
Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg
        275                 280                 285             
Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly
    290                 295                 300                 
Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe
305                 310                 315                 320 
Gln Ile Ser Asp Ile His Val Thr Gly Glu Ser Glu Asp Met Ser Ala
                325                 330                 335     
Lys Glu Arg Leu Leu Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala
            340                 345                 350         
Gly Ile Arg Cys Glu Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu
        355                 360                 365             
Phe Asn Ala Ile Ile His Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn
    370                 375                 380                 
Thr Val Ala Val Gln Ser Asn Leu Ala Asn Leu Glu His Ala Phe Tyr
385                 390                 395                 400 
Val Ala Glu Lys Ile Gly Val Ile Arg Leu Leu Asp Pro Glu Asp Val
                405                 410                 415     
Asp Val Ser Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser Ser
            420                 425                 430         
Leu Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile Gly
        435                 440                 445             
Ala Asn Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn
    450                 455                 460                 
Tyr Leu Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu Arg
465                 470                 475                 480 
Thr Phe Pro Asn Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr
                485                 490                 495     
Leu Gln Phe Lys Glu Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser
            500                 505                 510         
Lys Ile Lys Arg Leu Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe Gly
        515                 520                 525             
Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu
    530                 535                 540                 
Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg
545                 550                 555                 560 
Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val
                565                 570                 575     
Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn
            580                 585                 590         
Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln
        595                 600                 605             
Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu
    610                 615                 620                 
Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr
625                 630                 635                 640 
Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile
                645                 650                 655     
Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile
            660                 665                 670         
Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser
        675                 680                 685             
Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser Gly
    690                 695                 700                 
Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr Ser
705                 710                 715                 720 
Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr Pro
                725                 730                 735     
Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser Ser
            740                 745                 750         
Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile Arg
        755                 760                 765             
Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu Glu
    770                 775                 780                 
Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp Glu
785                 790                 795                 800 
Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro Ser
                805                 810                 815     
Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile Glu
            820                 825                 830         
Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln Met
        835                 840                 845             
Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu Glu
    850                 855                 860                 
Ser Gln Tyr Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn Thr Ser Arg
865                 870                 875                 880 
Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala
                885                 890                 895     
Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala
            900                 905                 910         
Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr
        915                 920                 925             
His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys
    930                 935                 940                 
Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala
945                 950                 955                 960 
Arg Leu Thr Ile Glu Val Lys Leu Glu Ser Val Met Val Leu Val Glu
                965                 970                 975     
Tyr Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu Gln
            980                 985                 990         
Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr Phe
        995                 1000                1005            
Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn Leu
    1010                1015                1020                
Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser Ile
1025                1030                1035                1040
His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu Glu
                1045                1050                1055    
Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala Lys
            1060                1065                1070        
Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys Thr
        1075                1080                1085            
Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile Thr
    1090                1095                1100                
Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg Ala
1105                1110                1115                1120
Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro Ser
                1125                1130                1135    
Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu Ala
            1140                1145                1150        
Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp His Glu
        1155                1160                1165            
Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu Ile Asn
    1170                1175                1180                
Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Val Ser Met Asn
1185                1190                1195                1200
Leu Tyr Ile Lys Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser
                1205                1210                1215    
Asn Leu Gln Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser
            1220                1225                1230        
Gln Val Phe Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn
        1235                1240                1245            
Val Cys Lys Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu
    1250                1255                1260                
Glu Gln Glu Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn
1265                1270                1275                1280
Ile Arg Leu Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile
                1285                1290                1295    
Arg Thr Pro Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile
            1300                1305                1310        
Thr Glu Gln Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp
        1315                1320                1325            
Leu Gly Thr Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala
    1330                1335                1340                
Ala Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu
1345                1350                1355                1360
Gln Asn Met Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys
                1365                1370                1375    
Tyr Val Thr Ala Ile Ser Ile Tyr Lys Cys Gly Tyr Cys Leu Ile Ser
            1380                1385                1390        
Phe Leu Arg Leu Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala
        1395                1400                1405            
Ala Glu Ala Leu Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu
    1410                1415                1420                
Ala Val Ile Ala Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu
1425                1430                1435                1440
Lys Gln Trp Arg Ser Glu Val Asp Glu Lys Arg Gln Val Phe His Ala
                1445                1450                1455    
Leu Glu Asp Glu Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe
            1460                1465                1470        
Lys Thr Tyr Lys Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys
        1475                1480                1485            
Ala Asp Gln Leu Val Glu Arg Trp Gln Asn Val His Val Gln Ile Asp
    1490                1495                1500                
Asn Arg Leu Arg Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr
1505                1510                1515                1520
Arg Asp Thr Tyr His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr
                1525                1530                1535    
Thr Gln Arg Lys Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu
            1540                1545                1550        
Ala Thr Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met
        1555                1560                1565            
Lys Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser
    1570                1575                1580                
Ala Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met
1585                1590                1595                1600
Val Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser
                1605                1610                1615    
Ser Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr
            1620                1625                1630        
Thr Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp
        1635                1640                1645            
Ser Leu Lys Arg Leu Glu Glu Glu Glu Val Ile Ile Asn Ser Glu His
    1650                1655                1660                
Pro Val Asn Ile Lys Glu Leu Glu Met Ser Ser Asn Tyr Ser Val Ile
1665                1670                1675                1680
Lys Arg Cys Lys Glu Thr Ser Glu His Gly Ala Tyr Ser Asp Leu Leu
                1685                1690                1695    
Gln Arg Gln Lys Ala Thr Val Leu Glu Asn Ser Lys Leu Thr Gly Lys
            1700                1705                1710        
Ile Ser Glu Leu Glu Arg Met Val Ala Glu Leu Lys Lys Gln Lys Ser
        1715                1720                1725            
Arg Val Glu Glu Glu Leu Pro Lys Val Arg Glu Ala Ala Glu Asn Glu
    1730                1735                1740                
Leu Arg Lys Gln Gln Arg Asn Val Glu Asp Ile Ser Leu Gln Lys Ile
1745                1750                1755                1760
Arg Ala Glu Ser Glu Ala Lys Gln Tyr Arg Arg Glu Leu Glu Thr Ile
                1765                1770                1775    
Val Arg Glu Lys Glu Ala Ala Glu Arg Glu Leu Glu Arg Val Arg Gln
            1780                1785                1790        
Leu Thr Ile Glu Ala Glu Ala Lys Arg Ala Ala Val Glu Glu Asn Leu
        1795                1800                1805            
Leu Asn Phe Arg Asn Gln Leu Glu Glu Asn Thr Phe Thr Arg Arg Thr
    1810                1815                1820                
Leu Glu Asp His Leu Lys Arg Lys Asp Leu Ser Leu Asn Asp Leu Glu
1825                1830                1835                1840
Gln Gln Lys Asn Lys Leu Met Glu Glu Leu Arg Arg Lys Arg Asp Asn
                1845                1850                1855    
Glu Glu Glu Leu Leu Lys Leu Ile Lys Gln Met Glu Lys Asp Leu Ala
            1860                1865                1870        
Phe Gln Lys Gln Val Ala Glu Lys Gln Leu Lys Glu Lys Gln Lys Ile
        1875                1880                1885            
Glu Leu Glu Ala Arg Arg Lys Ile Thr Glu Ile Gln Tyr Thr Cys Arg
    1890                1895                1900                
Glu Asn Ala Leu Pro Val Cys Pro Ile Thr Gln Ala Thr Ser Cys Arg
1905                1910                1915                1920
Ala Val Thr Gly Leu Gln Gln Glu His Asp Lys Gln Lys Ala Glu Glu
                1925                1930                1935    
Leu Lys Gln Gln Val Asp Glu Leu Thr Ala Ala Asn Arg Lys Ala Glu
            1940                1945                1950        
Gln Asp Met Arg Glu Leu Thr Tyr Glu Leu Asn Ala Leu Gln Leu Glu
        1955                1960                1965            
Lys Thr Ser Ser Glu Glu Lys Ala Arg Leu Leu Lys Asp Lys Leu Asp
    1970                1975                1980                
Glu Thr Asn Asn Thr Leu Arg Cys Leu Lys Leu Glu Leu Glu Arg Lys
1985                1990                1995                2000
Asp Gln Ala Glu Lys Gly Tyr Ser Gln Gln Leu Arg Glu Leu Gly Arg
                2005                2010                2015    
Gln Leu Asn Gln Thr Thr Gly Lys Ala Glu Glu Ala Met Gln Glu Ala
            2020                2025                2030        
Ser Asp Leu Lys Lys Ile Lys Arg Asn Tyr Gln Leu Glu Leu Glu Ser
        2035                2040                2045            
Leu Asn His Glu Lys Gly Lys Leu Gln Arg Glu Val Asp Arg Ile Thr
    2050                2055                2060                
Arg Ala His Ala Val Ala Glu Lys Asn Ile Gln His Leu Asn Ser Gln
2065                2070                2075                2080
Ile His Ser Phe Arg Asp Glu Lys Glu Leu Glu Arg Leu Gln Ile Cys
                2085                2090                2095    
Gln Arg Lys Ser Asp His Leu Lys Glu Gln Phe Glu Lys Ser His Glu
            2100                2105                2110        
Gln Leu Leu Gln Asn Ile Lys Ala Glu Lys Glu Asn Asn Asp Lys Ile
        2115                2120                2125            
Gln Arg Leu Asn Glu Glu Leu Glu Lys Ser Asn Glu Cys Ala Glu Met
    2130                2135                2140                
Leu Lys Gln Lys Val Glu Glu Leu Thr Arg Gln Asn Asn Glu Thr Lys
2145                2150                2155                2160
Leu Met Met Gln Arg Ile Gln Ala Glu Ser Glu Asn Ile Val Leu Glu
                2165                2170                2175    
Lys Gln Thr Ile Gln Gln Arg Cys Glu Ala Leu Lys Ile Gln Ala Asp
            2180                2185                2190        
Gly Phe Lys Asp Gln Leu Arg Ser Thr Asn Glu His Leu His Lys Gln
        2195                2200                2205            
Thr Lys Thr Glu Gln Asp Phe Gln Arg Lys Ile Lys Cys Leu Glu Glu
    2210                2215                2220                
Asp Leu Ala Lys Ser Gln Asn Leu Val Ser Glu Phe Lys Gln Lys Cys
2225                2230                2235                2240
Asp Gln Gln Asn Ile Ile Ile Gln Asn Thr Lys Lys Glu Val Arg Asn
                2245                2250                2255    
Leu Asn Ala Glu Leu Asn Ala Ser Lys Glu Glu Lys Arg Arg Gly Glu
            2260                2265                2270        
Gln Lys Val Gln Leu Gln Gln Ala Gln Val Gln Glu Leu Asn Asn Arg
        2275                2280                2285            
Leu Lys Lys Val Gln Asp Glu Leu His Leu Lys Thr Ile Glu Glu Gln
    2290                2295                2300                
Met Thr His Arg Lys Met Val Leu Phe Gln Glu Glu Ser Gly Lys Phe
2305                2310                2315                2320
Lys Gln Ser Ala Glu Glu Phe Arg Lys Lys Met Glu Lys Leu Met Glu
                2325                2330                2335    
Ser Lys Val Ile Thr Glu Asn Asp Ile Ser Gly Ile Arg Leu Asp Phe
            2340                2345                2350        
Val Ser Leu Gln Gln Glu Asn Ser Arg Ala Gln Glu Asn Ala Lys Leu
        2355                2360                2365            
Cys Glu Thr Asn Ile Lys Glu Leu Glu Arg Gln Leu Gln Gln Tyr Arg
    2370                2375                2380                
Glu Gln Met Gln Gln Gly Gln His Met Glu Ala Asn His Tyr Gln Lys
2385                2390                2395                2400
Cys Gln Lys Leu Glu Asp Glu Leu Ile Ala Gln Lys Arg Glu Val Glu
                2405                2410                2415    
Asn Leu Lys Gln Lys Met Asp Gln Gln Ile Lys Glu His Glu His Gln
            2420                2425                2430        
Leu Val Leu Leu Gln Cys Glu Ile Gln Lys Lys Ser Thr Ala Lys Asp
        2435                2440                2445            
Cys Thr Phe Lys Pro Asp Phe Glu Met Thr Val Lys Glu Cys Gln His
    2450                2455                2460                
Ser Gly Glu Leu Ser Ser Arg Asn Thr Gly His Leu His Pro Thr Pro
2465                2470                2475                2480
Arg Ser Pro Leu Leu Arg Trp Thr Gln Glu Pro Gln Pro Leu Glu Glu
                2485                2490                2495    
Lys Trp Gln His Arg Val Val Glu Gln Ile Pro Lys Glu Val Gln Phe
            2500                2505                2510        
Gln Pro Pro Gly Ala Pro Leu Glu Lys Glu Lys Ser Gln Gln Cys Tyr
        2515                2520                2525            
Ser Glu Tyr Phe Ser Gln Thr Ser Thr Glu Leu Gln Ile Thr Phe Asp
    2530                2535                2540                
Glu Thr Asn Pro Ile Thr Arg Leu Ser Glu Ile Glu Lys Ile Arg Asp
2545                2550                2555                2560
Gln Ala Leu Asn Asn Ser Arg Pro Pro Val Arg Tyr Gln Asp Asn Ala
                2565                2570                2575    
Cys Glu Met Glu Leu Val Lys Val Leu Thr Pro Leu Glu Ile Ala Lys
            2580                2585                2590        
Asn Lys Gln Tyr Asp Met His Thr Glu Val Thr Thr Leu Lys Gln Glu
        2595                2600                2605            
Lys Asn Pro Val Pro Ser Ala Glu Glu Trp Met Leu Glu Gly Cys Arg
    2610                2615                2620                
Ala Ser Gly Gly Leu Lys Lys Gly Asp Phe Leu Lys Lys Gly Leu Glu
2625                2630                2635                2640
Pro Glu Thr Phe Gln Asn Phe Asp Gly Asp His Ala Cys Ser Val Arg
                2645                2650                2655    
Asp Asp Glu Phe Lys Phe Gln Gly Leu Arg His Thr Val Thr Ala Arg
            2660                2665                2670        
Gln Leu Val Glu Ala Lys Leu Leu Asp Met Arg Thr Ile Glu Gln Leu
        2675                2680                2685            
Arg Leu Gly Leu Lys Thr Val Glu Glu Val Gln Lys Thr Leu Asn Lys
    2690                2695                2700                
Phe Leu Thr Lys Ala Thr Ser Ile Ala Gly Leu Tyr Leu Glu Ser Thr
2705                2710                2715                2720
Lys Glu Lys Ile Ser Phe Ala Ser Ala Ala Glu Arg Ile Ile Ile Asp
                2725                2730                2735    
Lys Met Val Ala Leu Ala Phe Leu Glu Ala Gln Ala Ala Thr Gly Phe
            2740                2745                2750        
Ile Ile Asp Pro Ile Ser Gly Gln Thr Tyr Ser Val Glu Asp Ala Val
        2755                2760                2765            
Leu Lys Gly Val Val Asp Pro Glu Phe Arg Ile Arg Leu Leu Glu Ala
    2770                2775                2780                
Glu Lys Ala Ala Val Gly Tyr Ser Tyr Ser Ser Lys Thr Leu Ser Val
2785                2790                2795                2800
Phe Gln Ala Met Glu Asn Arg Met Leu Asp Arg Gln Lys Gly Lys His
                2805                2810                2815    
Ile Leu Glu Ala Gln Ile Ala Ser Gly Gly Val Ile Asp Pro Val Arg
            2820                2825                2830        
Gly Ile Arg Val Pro Pro Glu Ile Ala Leu Gln Gln Gly Leu Leu Asn
        2835                2840                2845            
Asn Ala Ile Leu Gln Phe Leu His Glu Pro Ser Ser Asn Thr Arg Val
    2850                2855                2860                
Phe Pro Asn Pro Asn Asn Lys Gln Ala Leu Tyr Tyr Ser Glu Leu Leu
2865                2870                2875                2880
Arg Met Cys Val Phe Asp Val Glu Ser Gln Cys Phe Leu Phe Pro Phe
                2885                2890                2895    
Gly Glu Arg Asn Ile Ser Asn Leu Asn Val Lys Lys Thr His Arg Ile
            2900                2905                2910        
Ser Val Val Asp Thr Lys Thr Gly Ser Glu Leu Thr Val Tyr Glu Ala
        2915                2920                2925            
Phe Gln Arg Asn Leu Ile Glu Lys Ser Ile Tyr Leu Glu Leu Ser Gly
    2930                2935                2940                
Gln Gln Tyr Gln Trp Lys Glu Ala Met Phe Phe Glu Ser Tyr Gly His
2945                2950                2955                2960
Ser Ser His Met Leu Thr Asp Thr Lys Thr Gly Leu His Phe Asn Ile
                2965                2970                2975    
Asn Glu Ala Ile Glu Gln Gly Thr Ile Asp Lys Ala Leu Val Lys Lys
            2980                2985                2990        
Tyr Gln Glu Gly Leu Ile Thr Leu Thr Glu Leu Ala Asp Ser Leu Leu
        2995                3000                3005            
Ser Arg Leu Val Pro Lys Lys Asp Leu His Ser Pro Val Ala Gly Tyr
    3010                3015                3020                
Trp Leu Thr Ala Ser Gly Glu Arg Ile Ser Val Leu Lys Ala Ser Arg
3025                3030                3035                3040
Arg Asn Leu Val Asp Arg Ile Thr Ala Leu Arg Cys Leu Glu Ala Gln
                3045                3050                3055    
Val Ser Thr Gly Gly Ile Ile Asp Pro Leu Thr Gly Lys Lys Tyr Arg
            3060                3065                3070        
Val Ala Glu Ala Leu His Arg Gly Leu Val Asp Glu Gly Phe Ala Gln
        3075                3080                3085            
Gln Leu Arg Gln Cys Glu Leu Val Ile Thr Gly Ile Gly His Pro Ile
    3090                3095                3100                
Thr Asn Lys Met Met Ser Val Val Glu Ala Val Asn Ala Asn Ile Ile
3105                3110                3115                3120
Asn Lys Glu Met Gly Ile Arg Cys Leu Glu Phe Gln Tyr Leu Thr Gly
                3125                3130                3135    
Gly Leu Ile Glu Pro Gln Val His Ser Arg Leu Ser Ile Glu Glu Ala
            3140                3145                3150        
Leu Gln Val Gly Ile Ile Asp Val Leu Ile Ala Thr Lys Leu Lys Asp
        3155                3160                3165            
Gln Lys Ser Tyr Val Arg Asn Ile Ile Cys Pro Gln Thr Lys Arg Lys
    3170                3175                3180                
Leu Thr Tyr Lys Glu Ala Leu Glu Lys Ala Asp Phe Asp Phe His Thr
3185                3190                3195                3200
Gly Leu Lys Leu Leu Glu Val Ser Glu Pro Leu Met Thr Gly Ile Ser
                3205                3210                3215    
Ser Leu Tyr Tyr Ser Ser
            3220        


<210> 8419
<211> 2950
<212> PRT
<213> Homo sapiens

<400> 8419
Pro Ser Pro Arg Pro His His Asp Arg Arg Gly Phe Pro Arg Leu Ala
 1               5                  10                  15      
Glu Thr Leu Gln His Pro Met Cys Pro Leu Pro Leu Val Ala Ser Ala
            20                  25                  30          
Gly His His Arg His His Arg Leu Leu Leu Leu Leu Ala Pro Gln Ala
        35                  40                  45              
Pro Glu Arg Glu Ala Ser Asp Glu Ile Val Phe Ser Gly Arg Ser Arg
    50                  55                  60                  
Ser Arg Asp Ala Val Leu Arg Ser His His Phe Arg Ser Glu Gly Phe
65                  70                  75                  80  
Arg Ala Ser Pro Arg His Leu Arg Arg Arg Val Ala Ala Ala Ala Ala
                85                  90                  95      
Ala Arg Leu Glu Glu Val Lys Pro Val Val Glu Val His His Gln Ser
            100                 105                 110         
Glu Gln Glu Thr Ser Val Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg
        115                 120                 125             
Val Gln Pro Glu Phe Tyr His Ser Val Gln Gly Ala Ser Ile Arg Arg
    130                 135                 140                 
Pro Ser Ser Gly Asn Ala Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala
145                 150                 155                 160 
Asp Phe Ser Asp Glu Asp Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser
                165                 170                 175     
Pro Ala Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro Lys His Glu Arg
            180                 185                 190         
Ser Lys Arg Lys Ile Gln Gly Gly Ser Val Leu Asp Pro Ala Glu Arg
        195                 200                 205             
Ala Val Leu Arg Ile Ala Asp Glu Arg Asp Lys Val Gln Lys Lys Thr
    210                 215                 220                 
Phe Thr Lys Trp Ile Asn Gln His Leu Met Lys Val Arg Lys His Val
225                 230                 235                 240 
Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu
                245                 250                 255     
Leu Glu Val Leu Ser Gly Asp Thr Leu Pro Arg Glu Lys Gly Arg Met
            260                 265                 270         
Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys
        275                 280                 285             
Arg Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp
    290                 295                 300                 
Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His
305                 310                 315                 320 
Phe Gln Ile Ser Asp Ile His Val Thr Gly Glu Ser Glu Asp Met Ser
                325                 330                 335     
Ala Lys Glu Arg Leu Leu Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr
            340                 345                 350         
Ala Gly Ile Arg Cys Glu Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys
        355                 360                 365             
Leu Phe Asn Ala Ile Ile His Lys Tyr Arg Pro Asp Leu Ile Asp Met
    370                 375                 380                 
Asn Thr Val Ala Val Gln Ser Asn Leu Ala Asn Leu Glu His Ala Phe
385                 390                 395                 400 
Tyr Val Ala Glu Lys Ile Gly Val Ile Arg Leu Leu Asp Pro Glu Asp
                405                 410                 415     
Val Asp Val Ser Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser
            420                 425                 430         
Ser Leu Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile
        435                 440                 445             
Gly Ala Asn Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val
    450                 455                 460                 
Asn Tyr Leu Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu
465                 470                 475                 480 
Arg Thr Phe Pro Asn Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln
                485                 490                 495     
Tyr Leu Gln Phe Lys Glu Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys
            500                 505                 510         
Ser Lys Ile Lys Arg Leu Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe
        515                 520                 525             
Gly Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys
    530                 535                 540                 
Glu Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu
545                 550                 555                 560 
Arg Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg
                565                 570                 575     
Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly
            580                 585                 590         
Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe
        595                 600                 605             
Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu
    610                 615                 620                 
Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr
625                 630                 635                 640 
Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu
                645                 650                 655     
Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg
            660                 665                 670         
Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln
        675                 680                 685             
Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser
    690                 695                 700                 
Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr
705                 710                 715                 720 
Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr
                725                 730                 735     
Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser
            740                 745                 750         
Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile
        755                 760                 765             
Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu
    770                 775                 780                 
Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp
785                 790                 795                 800 
Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro
                805                 810                 815     
Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile
            820                 825                 830         
Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln
        835                 840                 845             
Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu
    850                 855                 860                 
Glu Ser Gln Tyr Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn Thr Ser
865                 870                 875                 880 
Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg
                885                 890                 895     
Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val
            900                 905                 910         
Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp
        915                 920                 925             
Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile
    930                 935                 940                 
Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro
945                 950                 955                 960 
Ala Arg Leu Thr Ile Glu Val Lys Leu Glu Ser Val Met Val Leu Val
                965                 970                 975     
Glu Tyr Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu
            980                 985                 990         
Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr
        995                 1000                1005            
Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn
    1010                1015                1020                
Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser
1025                1030                1035                1040
Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu
                1045                1050                1055    
Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala
            1060                1065                1070        
Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys
        1075                1080                1085            
Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile
    1090                1095                1100                
Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg
1105                1110                1115                1120
Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro
                1125                1130                1135    
Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu
            1140                1145                1150        
Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp His
        1155                1160                1165            
Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu Ile
    1170                1175                1180                
Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Val Ser Met
1185                1190                1195                1200
Asn Leu Ile Lys Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser
                1205                1210                1215    
Asn Leu Gln Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser
            1220                1225                1230        
Gln Val Phe Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn
        1235                1240                1245            
Val Cys Lys Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu
    1250                1255                1260                
Glu Gln Glu Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn
1265                1270                1275                1280
Ile Arg Leu Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile
                1285                1290                1295    
Arg Thr Pro Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile
            1300                1305                1310        
Thr Glu Gln Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp
        1315                1320                1325            
Leu Gly Thr Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala
    1330                1335                1340                
Ala Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu
1345                1350                1355                1360
Gln Asn Met Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys
                1365                1370                1375    
Tyr Val Thr Ala Ile Ser Ile Tyr Lys Gly Tyr Cys Leu Ile Ser Phe
            1380                1385                1390        
Leu Arg Leu Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln Ala Ala
        1395                1400                1405            
Glu Ala Leu Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala
    1410                1415                1420                
Val Ile Ala Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys
1425                1430                1435                1440
Gln Trp Arg Ser Glu Val Asp Glu Lys Arg Gln Val Phe His Ala Leu
                1445                1450                1455    
Glu Asp Glu Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met Phe Lys
            1460                1465                1470        
Thr Tyr Lys Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu Lys Ala
        1475                1480                1485            
Asp Gln Leu Val Glu Arg Trp Gln Asn Val His Val Gln Ile Asp Asn
    1490                1495                1500                
Arg Leu Arg Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg
1505                1510                1515                1520
Asp Thr Tyr His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu Thr Thr
                1525                1530                1535    
Gln Arg Lys Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala
            1540                1545                1550        
Thr Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met Lys
        1555                1560                1565            
Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala
    1570                1575                1580                
Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met Val
1585                1590                1595                1600
Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser Ser
                1605                1610                1615    
Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr
            1620                1625                1630        
Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser
        1635                1640                1645            
Leu Lys Arg Leu Glu Glu Glu Glu Val Ile Ile Asn Ser Glu His Pro
    1650                1655                1660                
Val Asn Ile Lys Glu Leu Glu Ile Lys Arg Cys Lys Glu Thr Ser Glu
1665                1670                1675                1680
His Gly Ala Tyr Ser Asp Leu Leu Gln Arg Gln Lys Ala Thr Val Leu
                1685                1690                1695    
Glu Asn Ser Lys Leu Thr Gly Lys Ile Ser Glu Leu Glu Arg Met Val
            1700                1705                1710        
Ala Glu Leu Lys Lys Gln Lys Ser Arg Val Glu Glu Glu Leu Pro Lys
        1715                1720                1725            
Val Arg Glu Ala Ala Glu Asn Glu Leu Arg Lys Gln Gln Arg Asn Val
    1730                1735                1740                
Glu Asp Ile Ser Leu Gln Lys Ile Arg Ala Glu Ser Glu Ala Lys Gln
1745                1750                1755                1760
Tyr Arg Arg Glu Leu Glu Thr Ile Val Arg Glu Lys Glu Ala Ala Glu
                1765                1770                1775    
Arg Glu Leu Glu Arg Val Arg Gln Leu Thr Ile Glu Ala Glu Ala Lys
            1780                1785                1790        
Arg Ala Ala Val Glu Glu Asn Leu Leu Asn Phe Arg Asn Gln Leu Glu
        1795                1800                1805            
Glu Asn Thr Phe Thr Arg Arg Thr Leu Glu Asp His Leu Lys Arg Lys
    1810                1815                1820                
Asp Leu Ser Leu Asn Asp Leu Glu Gln Gln Lys Asn Lys Leu Met Glu
1825                1830                1835                1840
Glu Leu Arg Arg Lys Arg Asp Asn Glu Glu Glu Leu Leu Lys Leu Ile
                1845                1850                1855    
Lys Gln Met Glu Lys Asp Leu Ala Phe Gln Lys Gln Val Ala Glu Lys
            1860                1865                1870        
Gln Leu Lys Glu Lys Gln Lys Ile Glu Leu Glu Ala Arg Arg Lys Ile
        1875                1880                1885            
Thr Glu Ile Gln Tyr Thr Cys Arg Glu Asn Ala Leu Pro Val Cys Pro
    1890                1895                1900                
Ile Thr Gln Ala Thr Ser Cys Arg Ala Val Thr Gly Leu Gln Gln Glu
1905                1910                1915                1920
His Asp Lys Gln Lys Ala Glu Glu Leu Lys Gln Gln Val Asp Glu Leu
                1925                1930                1935    
Thr Ala Ala Asn Arg Lys Ala Glu Gln Asp Met Arg Glu Leu Thr Tyr
            1940                1945                1950        
Glu Leu Asn Ala Leu Gln Leu Glu Lys Thr Ser Ser Glu Glu Lys Ala
        1955                1960                1965            
Arg Leu Leu Lys Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu Arg Cys
    1970                1975                1980                
Leu Lys Leu Glu Leu Glu Arg Lys Asp Gln Ala Glu Lys Gly Tyr Ser
1985                1990                1995                2000
Gln Gln Leu Arg Glu Leu Gly Arg Gln Leu Asn Gln Thr Thr Gly Lys
                2005                2010                2015    
Ala Glu Glu Ala Met Gln Glu Ala Ser Asp Leu Lys Lys Ile Lys Arg
            2020                2025                2030        
Asn Tyr Gln Leu Glu Leu Glu Ser Leu Asn His Glu Lys Gly Lys Leu
        2035                2040                2045            
Gln Arg Glu Val Asp Arg Ile Thr Arg Ala His Ala Val Ala Glu Lys
    2050                2055                2060                
Asn Ile Gln His Leu Asn Ser Gln Ile His Ser Phe Arg Asp Glu Lys
2065                2070                2075                2080
Glu Leu Glu Arg Leu Gln Ile Cys Gln Arg Lys Ser Asp His Leu Lys
                2085                2090                2095    
Glu Gln Phe Glu Lys Ser His Glu Gln Leu Leu Gln Asn Ile Lys Ala
            2100                2105                2110        
Glu Lys Glu Asn Asn Asp Lys Ile Gln Arg Leu Asn Glu Glu Leu Glu
        2115                2120                2125            
Lys Ser Asn Glu Cys Ala Glu Met Leu Lys Gln Lys Val Glu Glu Leu
    2130                2135                2140                
Thr Arg Gln Asn Asn Glu Thr Lys Leu Met Met Gln Arg Ile Gln Ala
2145                2150                2155                2160
Glu Ser Glu Asn Ile Val Leu Glu Lys Gln Thr Ile Gln Gln Arg Cys
                2165                2170                2175    
Glu Ala Leu Lys Ile Gln Ala Asp Gly Phe Lys Asp Gln Leu Arg Ser
            2180                2185                2190        
Thr Asn Glu His Leu His Lys Gln Thr Lys Thr Glu Gln Asp Phe Gln
        2195                2200                2205            
Arg Lys Ile Lys Cys Leu Glu Glu Asp Leu Ala Lys Ser Gln Asn Leu
    2210                2215                2220                
Val Ser Glu Phe Lys Gln Lys Cys Asp Gln Gln Asn Ile Ile Ile Gln
2225                2230                2235                2240
Asn Thr Lys Lys Glu Val Arg Asn Leu Asn Ala Glu Leu Asn Ala Ser
                2245                2250                2255    
Lys Glu Glu Lys Arg Arg Gly Glu Gln Lys Val Gln Leu Gln Gln Ala
            2260                2265                2270        
Gln Val Gln Glu Leu Asn Asn Arg Leu Lys Lys Val Gln Asp Glu Leu
        2275                2280                2285            
His Leu Lys Thr Ile Glu Glu Gln Met Thr His Arg Lys Met Val Leu
    2290                2295                2300                
Phe Gln Glu Glu Ser Gly Lys Phe Lys Gln Ser Ala Glu Glu Phe Arg
2305                2310                2315                2320
Lys Lys Met Glu Lys Leu Met Glu Ser Lys Val Ile Thr Glu Asn Asp
                2325                2330                2335    
Ile Ser Gly Ile Arg Leu Asp Phe Val Ser Leu Gln Gln Glu Asn Ser
            2340                2345                2350        
Arg Ala Gln Glu Asn Ala Lys Leu Cys Glu Thr Asn Ile Lys Glu Leu
        2355                2360                2365            
Glu Arg Gln Leu Gln Gln Tyr Arg Glu Gln Met Gln Gln Gly Gln His
    2370                2375                2380                
Met Glu Ala Asn His Tyr Gln Lys Cys Gln Lys Leu Glu Asp Glu Leu
2385                2390                2395                2400
Ile Ala Gln Lys Arg Glu Val Glu Asn Leu Lys Gln Lys Met Asp Gln
                2405                2410                2415    
Gln Ile Lys Glu His Glu His Gln Leu Val Leu Leu Gln Cys Glu Ile
            2420                2425                2430        
Gln Lys Lys Ser Thr Ala Lys Asp Cys Thr Phe Lys Pro Asp Phe Glu
        2435                2440                2445            
Met Thr Val Lys Glu Cys Gln His Ser Gly Glu Leu Ser Ser Arg Asn
    2450                2455                2460                
Thr Gly His Leu His Pro Thr Pro Arg Ser Pro Leu Leu Arg Trp Thr
2465                2470                2475                2480
Gln Glu Pro Gln Pro Leu Glu Glu Lys Trp Gln His Arg Val Val Glu
                2485                2490                2495    
Gln Ile Pro Lys Glu Val Gln Phe Gln Pro Pro Gly Ala Pro Leu Glu
            2500                2505                2510        
Lys Glu Lys Ser Gln Gln Cys Tyr Ser Glu Tyr Phe Ser Gln Thr Ser
        2515                2520                2525            
Thr Glu Leu Gln Ile Thr Phe Asp Glu Thr Asn Pro Ile Thr Arg Leu
    2530                2535                2540                
Ser Glu Ile Glu Lys Ile Arg Asp Gln Ala Leu Asn Asn Ser Arg Pro
2545                2550                2555                2560
Pro Val Arg Tyr Gln Asp Asn Ala Cys Glu Met Glu Leu Val Lys Val
                2565                2570                2575    
Leu Thr Pro Leu Glu Ile Ala Lys Asn Lys Gln Tyr Asp Met His Thr
            2580                2585                2590        
Glu Val Thr Thr Leu Lys Gln Glu Lys Asn Pro Val Pro Ser Ala Glu
        2595                2600                2605            
Glu Trp Met Leu Glu Gly Cys Arg Ala Ser Gly Gly Leu Lys Lys Gly
    2610                2615                2620                
Asp Phe Leu Lys Lys Gly Leu Glu Pro Glu Thr Phe Gln Asn Phe Asp
2625                2630                2635                2640
Gly Asp His Ala Cys Ser Val Arg Asp Asp Glu Phe Lys Phe Gln Gly
                2645                2650                2655    
Leu Arg His Thr Val Thr Ala Arg Gln Leu Val Glu Ala Lys Leu Leu
            2660                2665                2670        
Asp Met Arg Thr Ile Glu Gln Leu Arg Leu Gly Leu Lys Thr Val Glu
        2675                2680                2685            
Glu Val Gln Lys Thr Leu Asn Lys Phe Leu Thr Lys Ala Thr Ser Ile
    2690                2695                2700                
Ala Gly Leu Tyr Leu Glu Ser Thr Lys Glu Lys Ile Ser Phe Ala Ser
2705                2710                2715                2720
Ala Ala Glu Arg Ile Ile Ile Asp Lys Met Val Ala Leu Ala Phe Leu
                2725                2730                2735    
Glu Ala Gln Ala Ala Thr Gly Phe Ile Ile Asp Pro Ile Ser Gly Gln
            2740                2745                2750        
Thr Tyr Ser Val Glu Asp Ala Val Leu Lys Gly Val Val Asp Pro Glu
        2755                2760                2765            
Phe Arg Ile Arg Leu Leu Glu Ala Glu Lys Ala Ala Val Gly Tyr Ser
    2770                2775                2780                
Tyr Ser Ser Lys Thr Leu Ser Val Phe Gln Ala Met Glu Asn Arg Met
2785                2790                2795                2800
Leu Asp Arg Gln Lys Gly Lys His Ile Leu Glu Ala Gln Ile Ala Ser
                2805                2810                2815    
Gly Gly Val Ile Asp Pro Val Arg Gly Ile Arg Val Pro Pro Glu Ile
            2820                2825                2830        
Ala Leu Gln Gln Gly Leu Leu Asn Asn Ala Ile Leu Gln Phe Leu His
        2835                2840                2845            
Glu Pro Ser Ser Asn Thr Arg Val Phe Pro Asn Pro Asn Asn Lys Gln
    2850                2855                2860                
Ala Leu Tyr Tyr Ser Glu Leu Leu Arg Met Cys Val Phe Asp Val Glu
2865                2870                2875                2880
Ser Gln Cys Phe Leu Phe Pro Phe Gly Glu Arg Asn Ile Ser Asn Leu
                2885                2890                2895    
Asn Val Lys Lys Thr His Arg Ile Ser Val Val Asp Thr Lys Thr Gly
            2900                2905                2910        
Ser Glu Leu Thr Val Tyr Glu Ala Phe Gln Arg Asn Leu Ile Glu Lys
        2915                2920                2925            
Ser Ile Tyr Leu Glu Leu Ser Gly Pro Phe Trp Asp Thr Gly Phe Ser
    2930                2935                2940                
Leu Phe Arg Ser Lys Lys
2945                2950


<210> 8420
<211> 2704
<212> PRT
<213> Homo sapiens

<400> 8420
Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser
 1               5                  10                  15      
Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu
            20                  25                  30          
Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly
        35                  40                  45              
Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala
    50                  55                  60                  
Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu
65                  70                  75                  80  
Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val
                85                  90                  95      
Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu
            100                 105                 110         
Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly
        115                 120                 125             
Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg
    130                 135                 140                 
Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys
145                 150                 155                 160 
Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile
                165                 170                 175     
Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu
            180                 185                 190         
Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser
        195                 200                 205             
Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser
    210                 215                 220                 
Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn
225                 230                 235                 240 
Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met
                245                 250                 255     
Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu
            260                 265                 270         
Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp
        275                 280                 285             
Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp
    290                 295                 300                 
Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg
305                 310                 315                 320 
Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu
                325                 330                 335     
Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His
            340                 345                 350         
Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Phe Ser Leu Leu Lys Asn
        355                 360                 365             
Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe Val
    370                 375                 380                 
Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu
385                 390                 395                 400 
Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys
                405                 410                 415     
Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu
            420                 425                 430         
Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn
        435                 440                 445             
His Pro Ala Arg Leu Thr Ile Glu Val Lys Leu Glu Ser Val Met Val
    450                 455                 460                 
Leu Val Glu Tyr Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp
465                 470                 475                 480 
Ile Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr
                485                 490                 495     
Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu
            500                 505                 510         
Arg Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser
        515                 520                 525             
Ser Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu
    530                 535                 540                 
Lys Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly
545                 550                 555                 560 
Lys Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro
                565                 570                 575     
Leu Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile
            580                 585                 590         
Glu Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser
        595                 600                 605             
His Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met
    610                 615                 620                 
Val Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val
625                 630                 635                 640 
Asp Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu
                645                 650                 655     
Trp His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr
            660                 665                 670         
Leu Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Val
        675                 680                 685             
Ser Met Asn Leu Ile Lys Thr Met Leu Pro Gly Glu His Gln Gln Val
    690                 695                 700                 
Leu Ser Asn Leu Gln Ser Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln
705                 710                 715                 720 
Glu Ser Gln Val Phe Ser Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu
                725                 730                 735     
Val Asn Val Cys Lys Gln Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu
            740                 745                 750         
Arg Glu Glu Gln Glu Glu Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val
        755                 760                 765             
Arg Asn Ile Arg Leu Arg Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg
    770                 775                 780                 
Gln Ile Arg Thr Pro Leu Glu Arg Asp Asp Leu His Glu Ser Val Phe
785                 790                 795                 800 
Arg Ile Thr Glu Gln Glu Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys
                805                 810                 815     
Asp Asp Leu Gly Thr Ile Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln
            820                 825                 830         
Ala Ala Ala Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Val
        835                 840                 845             
Val Leu Gln Asn Met Asn Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile
    850                 855                 860                 
Asp Lys Tyr Val Thr Ala Ile Ser Ile Tyr Lys Gly Tyr Cys Leu Ile
865                 870                 875                 880 
Ser Phe Leu Arg Leu Lys Thr Val Asn Leu Val Leu Lys Asn Thr Gln
                885                 890                 895     
Ala Ala Glu Ala Leu Val Lys Leu Tyr Glu Thr Lys Leu Cys Glu Glu
            900                 905                 910         
Glu Ala Val Ile Ala Asp Lys Asn Asn Ile Glu Asn Leu Ile Ser Thr
        915                 920                 925             
Leu Lys Gln Trp Arg Ser Glu Val Asp Glu Lys Arg Gln Val Phe His
    930                 935                 940                 
Ala Leu Glu Asp Glu Leu Gln Lys Ala Lys Ala Ile Ser Asp Glu Met
945                 950                 955                 960 
Phe Lys Thr Tyr Lys Glu Arg Asp Leu Asp Phe Asp Trp His Lys Glu
                965                 970                 975     
Lys Ala Asp Gln Leu Val Glu Arg Trp Gln Asn Val His Val Gln Ile
            980                 985                 990         
Asp Asn Arg Leu Arg Asp Leu Glu Gly Ile Gly Lys Ser Leu Lys Tyr
        995                 1000                1005            
Tyr Arg Asp Thr Tyr His Pro Leu Asp Asp Trp Ile Gln Gln Val Glu
    1010                1015                1020                
Thr Thr Gln Arg Lys Ile Gln Glu Asn Gln Pro Glu Asn Ser Lys Thr
1025                1030                1035                1040
Leu Ala Thr Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu
                1045                1050                1055    
Met Lys Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr
            1060                1065                1070        
Ser Ala Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala
        1075                1080                1085            
Met Val Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln
    1090                1095                1100                
Ser Ser Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg
1105                1110                1115                1120
Tyr Thr Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly
                1125                1130                1135    
Asp Ser Leu Lys Arg Leu Glu Glu Glu Glu Val Ile Ile Asn Ser Glu
            1140                1145                1150        
His Pro Val Asn Ile Lys Glu Leu Glu Ile Lys Arg Cys Lys Glu Thr
        1155                1160                1165            
Ser Glu His Gly Ala Tyr Ser Asp Leu Leu Gln Arg Gln Lys Ala Thr
    1170                1175                1180                
Val Leu Glu Asn Ser Lys Leu Thr Gly Lys Ile Ser Glu Leu Glu Arg
1185                1190                1195                1200
Met Val Ala Glu Leu Lys Lys Gln Lys Ser Arg Val Glu Glu Glu Leu
                1205                1210                1215    
Pro Lys Val Arg Glu Ala Ala Glu Asn Glu Leu Arg Lys Gln Gln Arg
            1220                1225                1230        
Asn Val Glu Asp Ile Ser Leu Gln Lys Ile Arg Ala Glu Ser Glu Ala
        1235                1240                1245            
Lys Gln Tyr Arg Arg Glu Leu Glu Thr Ile Val Arg Glu Lys Glu Ala
    1250                1255                1260                
Ala Glu Arg Glu Leu Glu Arg Val Arg Gln Leu Thr Ile Glu Ala Glu
1265                1270                1275                1280
Ala Lys Arg Ala Ala Val Glu Glu Asn Leu Leu Asn Phe Arg Asn Gln
                1285                1290                1295    
Leu Glu Glu Asn Thr Phe Thr Arg Arg Thr Leu Glu Asp His Leu Lys
            1300                1305                1310        
Arg Lys Asp Leu Ser Leu Asn Asp Leu Glu Gln Gln Lys Asn Lys Leu
        1315                1320                1325            
Met Glu Glu Leu Arg Arg Lys Arg Asp Asn Glu Glu Glu Leu Leu Lys
    1330                1335                1340                
Leu Ile Lys Gln Met Glu Lys Asp Leu Ala Phe Gln Lys Gln Val Ala
1345                1350                1355                1360
Glu Lys Gln Leu Lys Glu Lys Gln Lys Ile Glu Leu Glu Ala Arg Arg
                1365                1370                1375    
Lys Ile Thr Glu Ile Gln Tyr Thr Cys Arg Glu Asn Ala Leu Pro Val
            1380                1385                1390        
Cys Pro Ile Thr Gln Ala Thr Ser Cys Arg Ala Val Thr Gly Leu Gln
        1395                1400                1405            
Gln Glu His Asp Lys Gln Lys Ala Glu Glu Leu Lys Gln Gln Val Asp
    1410                1415                1420                
Glu Leu Thr Ala Ala Asn Arg Lys Ala Glu Gln Asp Met Arg Glu Leu
1425                1430                1435                1440
Thr Tyr Glu Leu Asn Ala Leu Gln Leu Glu Lys Thr Ser Ser Glu Glu
                1445                1450                1455    
Lys Ala Arg Leu Leu Lys Asp Lys Leu Asp Glu Thr Asn Asn Thr Leu
            1460                1465                1470        
Arg Cys Leu Lys Leu Glu Leu Glu Arg Lys Asp Gln Ala Glu Lys Gly
        1475                1480                1485            
Tyr Ser Gln Gln Leu Arg Glu Leu Gly Arg Gln Leu Asn Gln Thr Thr
    1490                1495                1500                
Gly Lys Ala Glu Glu Ala Met Gln Glu Ala Ser Asp Leu Lys Lys Ile
1505                1510                1515                1520
Lys Arg Asn Tyr Gln Leu Glu Leu Glu Ser Leu Asn His Glu Lys Gly
                1525                1530                1535    
Lys Leu Gln Arg Glu Val Asp Arg Ile Thr Arg Ala His Ala Val Ala
            1540                1545                1550        
Glu Lys Asn Ile Gln His Leu Asn Ser Gln Ile His Ser Phe Arg Asp
        1555                1560                1565            
Glu Lys Glu Leu Glu Arg Leu Gln Ile Cys Gln Arg Lys Ser Asp His
    1570                1575                1580                
Leu Lys Glu Gln Phe Glu Lys Ser His Glu Gln Leu Leu Gln Asn Ile
1585                1590                1595                1600
Lys Ala Glu Lys Glu Asn Asn Asp Lys Ile Gln Arg Leu Asn Glu Glu
                1605                1610                1615    
Leu Glu Lys Ser Asn Glu Cys Ala Glu Met Leu Lys Gln Lys Val Glu
            1620                1625                1630        
Glu Leu Thr Arg Gln Asn Asn Glu Thr Lys Leu Met Met Gln Arg Ile
        1635                1640                1645            
Gln Ala Glu Ser Glu Asn Ile Val Leu Glu Lys Gln Thr Ile Gln Gln
    1650                1655                1660                
Arg Cys Glu Ala Leu Lys Ile Gln Ala Asp Gly Phe Lys Asp Gln Leu
1665                1670                1675                1680
Arg Ser Thr Asn Glu His Leu His Lys Gln Thr Lys Thr Glu Gln Asp
                1685                1690                1695    
Phe Gln Arg Lys Ile Lys Cys Leu Glu Glu Asp Leu Ala Lys Ser Gln
            1700                1705                1710        
Asn Leu Val Ser Glu Phe Lys Gln Lys Cys Asp Gln Gln Asn Ile Ile
        1715                1720                1725            
Ile Gln Asn Thr Lys Lys Glu Val Arg Asn Leu Asn Ala Glu Leu Asn
    1730                1735                1740                
Ala Ser Lys Glu Glu Lys Arg Arg Gly Glu Gln Lys Val Gln Leu Gln
1745                1750                1755                1760
Gln Ala Gln Val Gln Glu Leu Asn Asn Arg Leu Lys Lys Val Gln Asp
                1765                1770                1775    
Glu Leu His Leu Lys Thr Ile Glu Glu Gln Met Thr His Arg Lys Met
            1780                1785                1790        
Val Leu Phe Gln Glu Glu Ser Gly Lys Phe Lys Gln Ser Ala Glu Glu
        1795                1800                1805            
Phe Arg Lys Lys Met Glu Lys Leu Met Glu Ser Lys Val Ile Thr Glu
    1810                1815                1820                
Asn Asp Ile Ser Gly Ile Arg Leu Asp Phe Val Ser Leu Gln Gln Glu
1825                1830                1835                1840
Asn Ser Arg Ala Gln Glu Asn Ala Lys Leu Cys Glu Thr Asn Ile Lys
                1845                1850                1855    
Glu Leu Glu Arg Gln Leu Gln Gln Tyr Arg Glu Gln Met Gln Gln Gly
            1860                1865                1870        
Gln His Met Glu Ala Asn His Tyr Gln Lys Cys Gln Lys Leu Glu Asp
        1875                1880                1885            
Glu Leu Ile Ala Gln Lys Arg Glu Val Glu Asn Leu Lys Gln Lys Met
    1890                1895                1900                
Asp Gln Gln Ile Lys Glu His Glu His Gln Leu Val Leu Leu Gln Cys
1905                1910                1915                1920
Glu Ile Gln Lys Lys Ser Thr Ala Lys Asp Cys Thr Phe Lys Pro Asp
                1925                1930                1935    
Phe Glu Met Thr Val Lys Glu Cys Gln His Ser Gly Glu Leu Ser Ser
            1940                1945                1950        
Arg Asn Thr Gly His Leu His Pro Thr Pro Arg Ser Pro Leu Leu Arg
        1955                1960                1965            
Trp Thr Gln Glu Pro Gln Pro Leu Glu Glu Lys Trp Gln His Arg Val
    1970                1975                1980                
Val Glu Gln Ile Pro Lys Glu Val Gln Phe Gln Pro Pro Gly Ala Pro
1985                1990                1995                2000
Leu Glu Lys Glu Lys Ser Gln Gln Cys Tyr Ser Glu Tyr Phe Ser Gln
                2005                2010                2015    
Thr Ser Thr Glu Leu Gln Ile Thr Phe Asp Glu Thr Asn Pro Ile Thr
            2020                2025                2030        
Arg Leu Ser Glu Ile Glu Lys Ile Arg Asp Gln Ala Leu Asn Asn Ser
        2035                2040                2045            
Arg Pro Pro Val Arg Tyr Gln Asp Asn Ala Cys Glu Met Glu Leu Val
    2050                2055                2060                
Lys Val Leu Thr Pro Leu Glu Ile Ala Lys Asn Lys Gln Tyr Asp Met
2065                2070                2075                2080
His Thr Glu Val Thr Thr Leu Lys Gln Glu Lys Asn Pro Val Pro Ser
                2085                2090                2095    
Ala Glu Glu Trp Met Leu Glu Gly Cys Arg Ala Ser Gly Gly Leu Lys
            2100                2105                2110        
Lys Gly Asp Phe Leu Lys Lys Gly Leu Glu Pro Glu Thr Phe Gln Asn
        2115                2120                2125            
Phe Asp Gly Asp His Ala Cys Ser Val Arg Asp Asp Glu Phe Lys Phe
    2130                2135                2140                
Gln Gly Leu Arg His Thr Val Thr Ala Arg Gln Leu Val Glu Ala Lys
2145                2150                2155                2160
Leu Leu Asp Met Arg Thr Ile Glu Gln Leu Arg Leu Gly Leu Lys Thr
                2165                2170                2175    
Val Glu Glu Val Gln Lys Thr Leu Asn Lys Phe Leu Thr Lys Ala Thr
            2180                2185                2190        
Ser Ile Ala Gly Leu Tyr Leu Glu Ser Thr Lys Glu Lys Ile Ser Phe
        2195                2200                2205            
Ala Ser Ala Ala Glu Arg Ile Ile Ile Asp Lys Met Val Ala Leu Ala
    2210                2215                2220                
Phe Leu Glu Ala Gln Ala Ala Thr Gly Phe Ile Ile Asp Pro Ile Ser
2225                2230                2235                2240
Gly Gln Thr Tyr Ser Val Glu Asp Ala Val Leu Lys Gly Val Val Asp
                2245                2250                2255    
Pro Glu Phe Arg Ile Arg Leu Leu Glu Ala Glu Lys Ala Ala Val Gly
            2260                2265                2270        
Tyr Ser Tyr Ser Ser Lys Thr Leu Ser Val Phe Gln Ala Met Glu Asn
        2275                2280                2285            
Arg Met Leu Asp Arg Gln Lys Gly Lys His Ile Leu Glu Ala Gln Ile
    2290                2295                2300                
Ala Ser Gly Gly Val Ile Asp Pro Val Arg Gly Ile Arg Val Pro Pro
2305                2310                2315                2320
Glu Ile Ala Leu Gln Gln Gly Leu Leu Asn Asn Ala Ile Leu Gln Phe
                2325                2330                2335    
Leu His Glu Pro Ser Ser Asn Thr Arg Val Phe Pro Asn Pro Asn Asn
            2340                2345                2350        
Lys Gln Ala Leu Tyr Tyr Ser Glu Leu Leu Arg Met Cys Val Phe Asp
        2355                2360                2365            
Val Glu Ser Gln Cys Phe Leu Phe Pro Phe Gly Glu Arg Asn Ile Ser
    2370                2375                2380                
Asn Leu Asn Val Lys Lys Thr His Arg Ile Ser Val Val Asp Thr Lys
2385                2390                2395                2400
Thr Gly Ser Glu Leu Thr Val Tyr Glu Ala Phe Gln Arg Asn Leu Ile
                2405                2410                2415    
Glu Lys Ser Ile Tyr Leu Glu Leu Ser Gly Gln Gln Tyr Gln Trp Lys
            2420                2425                2430        
Glu Ala Met Phe Phe Glu Ser Tyr Gly His Ser Ser His Met Leu Thr
        2435                2440                2445            
Asp Thr Lys Thr Gly Leu His Phe Asn Ile Asn Glu Ala Ile Glu Gln
    2450                2455                2460                
Gly Thr Ile Asp Lys Ala Leu Val Lys Lys Tyr Gln Glu Gly Leu Ile
2465                2470                2475                2480
Thr Leu Thr Glu Leu Ala Asp Ser Leu Leu Ser Arg Leu Val Pro Lys
                2485                2490                2495    
Lys Asp Leu His Ser Pro Val Ala Gly Tyr Trp Leu Thr Ala Ser Gly
            2500                2505                2510        
Glu Arg Ile Ser Val Leu Lys Ala Ser Arg Arg Asn Leu Val Asp Arg
        2515                2520                2525            
Ile Thr Ala Leu Arg Cys Leu Glu Ala Gln Val Ser Thr Gly Gly Ile
    2530                2535                2540                
Ile Asp Pro Leu Thr Gly Lys Lys Tyr Arg Val Ala Glu Ala Leu His
2545                2550                2555                2560
Arg Gly Leu Val Asp Glu Gly Phe Ala Gln Gln Leu Arg Gln Cys Glu
                2565                2570                2575    
Leu Val Ile Thr Gly Ile Gly His Pro Ile Thr Asn Lys Met Met Ser
            2580                2585                2590        
Val Val Glu Ala Val Asn Ala Asn Ile Ile Asn Lys Glu Met Gly Ile
        2595                2600                2605            
Arg Cys Leu Glu Phe Gln Tyr Leu Thr Gly Gly Leu Ile Glu Pro Gln
    2610                2615                2620                
Val His Ser Arg Leu Ser Ile Glu Glu Ala Leu Gln Val Gly Ile Ile
2625                2630                2635                2640
Asp Val Leu Ile Ala Thr Lys Leu Lys Asp Gln Lys Ser Tyr Val Arg
                2645                2650                2655    
Asn Ile Ile Cys Pro Gln Thr Lys Arg Lys Leu Thr Tyr Lys Glu Ala
            2660                2665                2670        
Leu Glu Lys Ala Asp Phe Asp Phe His Thr Gly Leu Lys Leu Leu Glu
        2675                2680                2685            
Val Ser Glu Pro Leu Met Thr Gly Ile Ser Ser Leu Tyr Tyr Ser Ser
    2690                2695                2700                


<210> 8421
<211> 2319
<212> PRT
<213> Homo sapiens

<400> 8421
Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Asp Leu
 1               5                  10                  15      
Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro
            20                  25                  30          
Thr Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser
        35                  40                  45              
Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Thr Gly Ala Asp Trp
    50                  55                  60                  
Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg Met Thr
65                  70                  75                  80  
Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp Ser Asp
                85                  90                  95      
Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu
            100                 105                 110         
Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Thr Glu
        115                 120                 125             
Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile
    130                 135                 140                 
His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val
145                 150                 155                 160 
Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr
                165                 170                 175     
Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr Lys Glu
            180                 185                 190         
Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln Leu Thr
        195                 200                 205             
Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Thr Ala
    210                 215                 220                 
Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu
225                 230                 235                 240 
Gly Asp Met Thr Ser Ser Gln Val Lys Thr Lys Pro Phe Asp Ser Trp
                245                 250                 255     
Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val
            260                 265                 270         
Gly Leu Leu Thr Val Ala Ala Asp Ser Ile Ser Thr Asn Gly Ser Glu
        275                 280                 285             
Ala Val Thr Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys
    290                 295                 300                 
Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly
305                 310                 315                 320 
Leu Thr Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Thr Asn Ala
                325                 330                 335     
Ala Gln Pro Ser Ser Glu Thr Val Gln Gln Glu Ser Ser Ser Ser Ser
            340                 345                 350         
His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Thr
        355                 360                 365             
Pro Lys Arg Thr Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro
    370                 375                 380                 
Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Thr
385                 390                 395                 400 
Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp
                405                 410                 415     
Leu Lys Pro Glu Met Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro
            420                 425                 430         
Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser
        435                 440                 445             
Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn
    450                 455                 460                 
Gly Asn Leu Glu Asn Thr Val Lys Phe His Ile Lys Glu Ile Ser Ser
465                 470                 475                 480 
Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys
                485                 490                 495     
Lys Pro His Lys Thr Ser Glu Glu Val Pro Pro Cys Arg Thr Pro Lys
            500                 505                 510         
Arg Gly Thr Gly Ser Gly Lys Gln Ala Lys Asn Thr Lys Ser Ser Ala
        515                 520                 525             
Val Pro Asn Gly Glu Leu Ser Tyr Thr Ser Lys Ala Ile Glu Gly Pro
    530                 535                 540                 
Gln Thr Asn Ser Ala Ser Thr Ser Ser Leu Glu Pro Cys Asn Gln Arg
545                 550                 555                 560 
Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Thr Ser Ser Ser Pro
                565                 570                 575     
Ala Phe Thr Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met
            580                 585                 590         
Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala
        595                 600                 605             
Ser Ser Pro Ser His Val Thr Arg Asn Gly Glu Val Val Glu Ala Trp
    610                 615                 620                 
Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr
625                 630                 635                 640 
Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Thr Lys Leu Leu Pro Gln
                645                 650                 655     
Lys Pro Arg Gly Glu Thr Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser
            660                 665                 670         
Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Val Lys Lys
        675                 680                 685             
Lys His Thr Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile
    690                 695                 700                 
Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile
705                 710                 715                 720 
Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr
                725                 730                 735     
Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser
            740                 745                 750         
His Ser Ala Thr Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile
        755                 760                 765             
Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe
    770                 775                 780                 
Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu
785                 790                 795                 800 
Thr Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Met Asp Asp Leu Lys
                805                 810                 815     
Leu Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His
            820                 825                 830         
Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu
        835                 840                 845             
Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile
    850                 855                 860                 
Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser
865                 870                 875                 880 
Trp Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr
                885                 890                 895     
Asp Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu
            900                 905                 910         
Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met
        915                 920                 925             
Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Ser Ser Lys Arg Lys
    930                 935                 940                 
Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly
945                 950                 955                 960 
Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Cys Leu Ile
                965                 970                 975     
Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu
            980                 985                 990         
Glu Gln Gln Gln His Leu Tyr Lys Arg Tyr Ser Val Glu Met Ser Ile
        995                 1000                1005            
Arg His Leu Lys Lys Thr Glu Leu Leu Ser Lys Val Glu Ala Leu Lys
    1010                1015                1020                
Lys Gly Gly Val Leu Leu Pro Asn Asp Leu Leu Glu Lys Val Asp Ser
1025                1030                1035                1040
Ile Asn Glu Lys Trp Glu Leu Leu Gly Lys Thr Leu Gly Glu Lys Ile
                1045                1050                1055    
Gln Asp Thr Met Ala Gly His Ser Gly Ser Ser Pro Arg Asp Leu Leu
            1060                1065                1070        
Ser Pro Glu Ser Gly Ser Leu Val Arg Gln Leu Glu Val Arg Ile Lys
        1075                1080                1085            
Glu Leu Lys Gly Trp Leu Arg Asp Thr Glu Leu Phe Ile Phe Asn Ser
    1090                1095                1100                
Cys Leu Arg Gln Glu Lys Glu Gly Thr Met Asn Thr Glu Lys Gln Leu
1105                1110                1115                1120
Gln Tyr Phe Lys Ser Leu Cys Arg Glu Ile Lys Gln Arg Arg Arg Gly
                1125                1130                1135    
Val Ala Ser Ile Leu Arg Leu Cys Gln His Leu Leu Asp Asp Arg Glu
            1140                1145                1150        
Thr Cys Asn Leu Asn Ala Asp His Gln Pro Met Gln Leu Ile Ile Val
        1155                1160                1165            
Asn Leu Glu Arg Arg Trp Glu Ala Ile Val Met Gln Ala Val Gln Trp
    1170                1175                1180                
Gln Thr Arg Leu Gln Lys Lys Met Gly Lys Glu Ser Glu Thr Leu Asn
1185                1190                1195                1200
Val Ile Asp Pro Gly Leu Met Asp Leu Asn Gly Met Ser Glu Asp Ala
                1205                1210                1215    
Leu Glu Trp Asp Glu Met Asp Ile Ser Asn Lys Leu Ile Ser Leu Asn
            1220                1225                1230        
Glu Glu Ser Asn Asp Leu Asp Gln Glu Leu Gln Pro Val Ile Pro Ser
        1235                1240                1245            
Leu Lys Leu Gly Glu Thr Ser Asn Glu Asp Pro Gly Tyr Asp Glu Glu
    1250                1255                1260                
Ala Asp Asn His Gly Gly Ser Gln Tyr Ala Ser Asn Ile Thr Ala Pro
1265                1270                1275                1280
Ser Ser Pro His Ile Tyr Gln Val Tyr Ser Leu His Asn Val Glu Leu
                1285                1290                1295    
Tyr Glu Asp Asn His Met Pro Phe Leu Lys Asn Asn Pro Lys Val Thr
            1300                1305                1310        
Gly Met Thr Gln Pro Asn Val Leu Thr Lys Ser Leu Ser Lys Asp Ser
        1315                1320                1325            
Ser Phe Ser Ser Thr Lys Ser Leu Pro Asp Leu Leu Gly Gly Ser Asn
    1330                1335                1340                
Leu Val Lys Pro Cys Ala Cys His Gly Gly Asp Met Ser Gln Asn Ser
1345                1350                1355                1360
Gly Ser Glu Ser Gly Ile Val Ser Glu Gly Asp Thr Glu Thr Thr Thr
                1365                1370                1375    
Asn Ser Glu Met Cys Leu Leu Asn Ala Val Asp Gly Ser Pro Ser Asn
            1380                1385                1390        
Leu Glu Thr Glu His Leu Asp Pro Gln Met Gly Asp Ala Val Asn Val
        1395                1400                1405            
Leu Lys Gln Lys Phe Thr Asp Glu Gly Glu Ser Ile Lys Leu Pro Asn
    1410                1415                1420                
Ser Ser Gln Ser Ser Ile Ser Pro Val Gly Cys Val Asn Gly Lys Val
1425                1430                1435                1440
Gly Asp Leu Asn Ser Ile Thr Lys His Thr Pro Asp Cys Leu Gly Glu
                1445                1450                1455    
Glu Leu Gln Gly Lys His Asp Val Phe Thr Phe Tyr Asp Tyr Ser Tyr
            1460                1465                1470        
Leu Gln Gly Ser Lys Leu Lys Leu Pro Met Ile Met Lys Gln Ser Gln
        1475                1480                1485            
Ser Glu Lys Val His Val Glu Asp Pro Leu Leu Arg Gly Phe Tyr Phe
    1490                1495                1500                
Asp Lys Lys Ser Cys Lys Ser Lys His Gln Thr Thr Glu Leu Gln Pro
1505                1510                1515                1520
Asp Val Pro Pro His Glu Arg Ile Leu Ala Ser Ala Ser His Glu Met
                1525                1530                1535    
Asp Arg Ile Ser Tyr Lys Ser Gly Asn Ile Glu Lys Thr Phe Thr Gly
            1540                1545                1550        
Met Gln Asn Ala Lys Gln Leu Ser Leu Leu Ser His Ser Ser Ser Ile
        1555                1560                1565            
Glu Ser Leu Ser Pro Gly Gly Asp Leu Phe Gly Leu Gly Ile Phe Lys
    1570                1575                1580                
Asn Gly Ser Asp Ser Leu Gln Arg Ser Thr Ser Leu Glu Ser Trp Leu
1585                1590                1595                1600
Thr Ser Tyr Lys Ser Asn Glu Asp Leu Phe Ser Cys His Ser Ser Gly
                1605                1610                1615    
Asp Ile Ser Val Ser Ser Gly Ser Val Gly Glu Leu Ser Lys Arg Thr
            1620                1625                1630        
Leu Asp Leu Leu Asn Arg Leu Glu Asn Ile Gln Ser Pro Ser Glu Gln
        1635                1640                1645            
Lys Ile Lys Arg Ser Val Ser Asp Ile Thr Leu Gln Ser Ser Ser Gln
    1650                1655                1660                
Lys Met Ser Phe Thr Gly Gln Met Ser Leu Asp Ile Ala Ser Ser Ile
1665                1670                1675                1680
Asn Glu Asp Ser Ala Ala Ser Leu Thr Glu Leu Ser Ser Ser Asp Glu
                1685                1690                1695    
Leu Ser Leu Cys Ser Glu Asp Ile Val Leu His Lys Asn Lys Ile Pro
            1700                1705                1710        
Glu Ser Asn Ala Ser Phe Arg Lys Arg Leu Thr Arg Ser Val Ala Asp
        1715                1720                1725            
Glu Ser Asp Val Asn Val Ser Met Ile Val Asn Val Ser Cys Thr Ser
    1730                1735                1740                
Ala Cys Thr Asp Asp Glu Asp Asp Ser Asp Leu Leu Ser Ser Ser Thr
1745                1750                1755                1760
Leu Thr Leu Thr Glu Glu Glu Leu Cys Ile Lys Asp Glu Asp Asp Asp
                1765                1770                1775    
Ser Ser Ile Ala Thr Asp Asp Glu Ile Tyr Glu Asp Cys Thr Leu Met
            1780                1785                1790        
Ser Gly Leu Asp Tyr Ile Lys Asn Glu Leu Gln Thr Trp Ile Arg Pro
        1795                1800                1805            
Lys Leu Ser Leu Thr Arg Asp Lys Lys Arg Cys Asn Val Ser Asp Glu
    1810                1815                1820                
Met Lys Gly Ser Lys Asp Ile Ser Ser Ser Glu Met Thr Asn Pro Ser
1825                1830                1835                1840
Asp Thr Leu Asn Ile Glu Thr Leu Leu Asn Gly Ser Val Lys Arg Val
                1845                1850                1855    
Ser Glu Asn Asn Gly Asn Gly Lys Asn Ser Ser His Thr His Glu Leu
            1860                1865                1870        
Gly Thr Lys Arg Glu Asn Lys Lys Thr Ile Phe Lys Val Asn Lys Asp
        1875                1880                1885            
Pro Tyr Val Ala Asp Met Glu Asn Gly Asn Ile Glu Gly Ile Pro Glu
    1890                1895                1900                
Arg Gln Lys Gly Lys Pro Asn Val Thr Ser Lys Val Ser Glu Asn Leu
1905                1910                1915                1920
Gly Ser His Gly Lys Glu Ile Ser Glu Ser Glu His Cys Lys Cys Lys
                1925                1930                1935    
Ala Leu Met Asp Ser Leu Asp Asp Ser Asn Thr Ala Gly Lys Glu Phe
            1940                1945                1950        
Val Ser Gln Asp Val Arg His Leu Pro Lys Lys Cys Pro Asn His His
        1955                1960                1965            
His Phe Glu Asn Gln Ser Thr Ala Ser Thr Pro Thr Glu Lys Ser Phe
    1970                1975                1980                
Ser Glu Leu Ala Leu Glu Thr Arg Phe Asn Asn Arg Gln Asp Ser Asp
1985                1990                1995                2000
Ala Leu Lys Ser Ser Asp Asp Ala Pro Ser Met Ala Gly Lys Ser Ala
                2005                2010                2015    
Gly Cys Cys Leu Ala Leu Glu Gln Asn Gly Thr Glu Glu Asn Ala Ser
            2020                2025                2030        
Ile Ser Asn Ile Ser Cys Cys Asn Cys Glu Pro Asp Val Phe His Gln
        2035                2040                2045            
Lys Asp Ala Glu Asp Cys Ser Val His Asn Phe Val Lys Glu Ile Ile
    2050                2055                2060                
Asp Met Ala Ser Thr Ala Leu Lys Ser Lys Ser Gln Pro Glu Asn Glu
2065                2070                2075                2080
Val Ala Ala Pro Thr Ser Leu Thr Gln Ile Lys Glu Lys Val Leu Glu
                2085                2090                2095    
His Ser His Arg Pro Ile Gln Leu Arg Lys Gly Asp Phe Tyr Ser Tyr
            2100                2105                2110        
Leu Ser Leu Ser Ser His Asp Ser Asp Cys Gly Glu Val Thr Asn Tyr
        2115                2120                2125            
Ile Glu Glu Lys Ser Ser Thr Pro Leu Pro Leu Asp Thr Thr Asp Ser
    2130                2135                2140                
Gly Leu Asp Asp Lys Glu Asp Ile Glu Cys Phe Phe Glu Ala Cys Val
2145                2150                2155                2160
Glu Gly Asp Ser Asp Gly Glu Glu Pro Cys Phe Ser Ser Ala Pro Pro
                2165                2170                2175    
Asn Glu Ser Ala Val Pro Ser Glu Ala Ala Met Pro Leu Gln Ala Thr
            2180                2185                2190        
Ala Cys Ser Ser Glu Phe Ser Asp Ser Ser Leu Ser Ala Asp Asp Ala
        2195                2200                2205            
Asp Thr Val Ala Leu Ser Ser Pro Ser Ser Gln Glu Arg Ala Glu Val
    2210                2215                2220                
Gly Lys Glu Val Asn Gly Leu Pro Gln Thr Ser Ser Gly Cys Ala Glu
2225                2230                2235                2240
Asn Leu Glu Phe Thr Pro Ser Lys Leu Asp Ser Glu Lys Glu Ser Ser
                2245                2250                2255    
Gly Lys Pro Gly Glu Ser Gly Met Pro Glu Glu His Asn Ala Ala Ser
            2260                2265                2270        
Ala Lys Ser Lys Val Gln Asp Leu Ser Leu Lys Ala Asn Gln Pro Thr
        2275                2280                2285            
Asp Lys Ala Ala Leu His Pro Ser Pro Lys Thr Leu Thr Cys Glu Glu
    2290                2295                2300                
Asn Leu Leu Asn Leu His Glu Lys Arg His Arg Asn Met His Arg
2305                2310                2315                


<210> 8422
<211> 1946
<212> PRT
<213> Homo sapiens

<400> 8422
Val Lys Tyr Thr Thr Trp Met Phe Glu Thr Gln Pro Ile Asp Thr Leu
 1               5                  10                  15      
Gly Ala Tyr Ser Ser Asp Thr Val Glu Asn Ala Glu Lys Ile Pro Glu
            20                  25                  30          
Leu Ala Arg Gly Asp Val Cys Thr Ala Arg Trp Met Phe Glu Thr Arg
        35                  40                  45              
Pro Leu Asp Ser Met Asn Lys Met His Gln Ser Gln Glu Glu Ser Ala
    50                  55                  60                  
Val Thr Ile Ser Lys Asp Ile Thr Gly Gly Asp Val Lys Thr Val Arg
65                  70                  75                  80  
Tyr Met Phe Glu Thr Gln His Leu Asp Gln Leu Gly Gln Leu His Ser
                85                  90                  95      
Val Asp Glu Val His Leu Leu Gln Leu Arg Ser Glu Leu Lys Glu Ile
            100                 105                 110         
Lys Gly Asn Val Lys Arg Ser Ile Lys Cys Phe Glu Thr Gln Pro Leu
        115                 120                 125             
Tyr Val Ile Arg Asp Gly Ser Gly Gln Met Leu Glu Ile Lys Thr Val
    130                 135                 140                 
His Arg Glu Asp Val Glu Lys Gly Asp Val Arg Thr Ala Arg Trp Met
145                 150                 155                 160 
Phe Glu Thr Gln Pro Leu Asp Thr Ile Asn Lys Asp Ile Thr Glu Ile
                165                 170                 175     
Lys Val Val Arg Gly Ile Ser Met Glu Glu Asn Val Lys Gly Gly Val
            180                 185                 190         
Ser Lys Ala Lys Trp Leu Phe Glu Thr Gln Pro Leu Glu Lys Ile Lys
        195                 200                 205             
Glu Ser Glu Glu Val Ile Ile Glu Lys Glu Lys Ile Ile Gly Thr Asp
    210                 215                 220                 
Val Ser Arg Lys Cys Trp Met Phe Glu Thr Gln Pro Leu Asp Ile Leu
225                 230                 235                 240 
Lys Glu Val Pro Asp Ala Asp Ser Leu Gln Arg Glu Glu Ile Ile Gly
                245                 250                 255     
Gly Asp Val Gln Thr Thr Lys His Leu Phe Glu Thr Leu Pro Ile Glu
            260                 265                 270         
Ala Leu Lys Asp Ser Pro Asp Ile Gly Lys Leu Gln Lys Ile Thr Ala
        275                 280                 285             
Ser Glu Glu Glu Lys Gly Asp Val Arg His Gln Lys Trp Ile Phe Glu
    290                 295                 300                 
Thr Gln Pro Leu Glu Asp Ile Arg Lys Asp Lys Lys Glu Tyr Thr Arg
305                 310                 315                 320 
Thr Val Lys Leu Glu Glu Val Asp Arg Gly Asp Val Lys Asn Tyr Thr
                325                 330                 335     
His Ile Phe Glu Ser Asn Asn Leu Ile Lys Phe Asp Ala Ser His Lys
            340                 345                 350         
Ile Glu Val Glu Gly Val Thr Arg Gly Ala Val Glu Leu Asn Lys Ser
        355                 360                 365             
Leu Phe Glu Thr Thr Pro Leu Tyr Ala Ile Gln Asp Pro Leu Gly Lys
    370                 375                 380                 
Tyr His Gln Val Lys Thr Val Gln Gln Glu Glu Ile Val Arg Gly Asp
385                 390                 395                 400 
Val Arg Ser Cys Arg Trp Leu Phe Glu Thr Arg Pro Ile Asp Gln Phe
                405                 410                 415     
Asp Glu Ser Ile His Lys Phe Gln Ile Ile Arg Gly Ile Ser Ala Gln
            420                 425                 430         
Glu Ile Gln Thr Gly Asn Val Lys Ser Ala Lys Trp Leu Phe Glu Thr
        435                 440                 445             
Gln Pro Leu Asp Ser Ile Lys Tyr Phe Ser Asp Val Glu Glu Thr Glu
    450                 455                 460                 
Ser Lys Thr Glu Gln Thr Arg Asp Ile Val Lys Gly Asp Val Lys Thr
465                 470                 475                 480 
Cys Lys Trp Leu Phe Glu Thr Leu Pro Met Glu Ser Leu Tyr Glu Lys
                485                 490                 495     
Val Ser Leu Met Thr Ser Ser Glu Glu Ile His Lys Gly Asp Val Lys
            500                 505                 510         
Thr Cys Thr Trp Leu Phe Glu Thr Gln Pro Leu Asp Thr Ile Lys Asp
        515                 520                 525             
Asp Ser Glu Thr Ala Val Lys Leu Gln Thr Val Lys Gln Glu Glu Ile
    530                 535                 540                 
Gln Gly Gly Asp Val Arg Thr Ala Cys Phe Leu Phe Glu Thr Glu Asn
545                 550                 555                 560 
Leu Asp Ser Ile Gln Gly Glu Glu Val Lys Glu Ile Lys Pro Val Glu
                565                 570                 575     
Met Asp Ile Gln Ala Gly Asp Val Ser Ser Met Arg Tyr Lys Phe Glu
            580                 585                 590         
Asn Gln Ser Leu Asp Ser Ile Ser Ser Ser Ser Glu Glu Val Leu Lys
        595                 600                 605             
Lys Ile Lys Thr Leu Lys Thr Glu Asp Ile Gln Lys Gly Asn Val Leu
    610                 615                 620                 
Asn Cys Arg Trp Leu Phe Glu Asn Gln Pro Ile Asp Lys Ile Lys Glu
625                 630                 635                 640 
Ser Gln Glu Gly Asp Glu Cys Val Lys Thr Val Thr Asp Ile Gln Gly
                645                 650                 655     
Gly Asp Val Arg Lys Gly Cys Phe Ile Phe Glu Thr Phe Ser Leu Asp
            660                 665                 670         
Glu Ile Lys Glu Glu Ser Asp Tyr Ile Ser Thr Lys Lys Thr Ile Thr
        675                 680                 685             
Glu Glu Val Ile Gln Gly Asp Val Lys Ser Tyr Arg Met Leu Phe Glu
    690                 695                 700                 
Thr Arg Pro Leu Tyr Ala Ile Gln Asp Arg Glu Gly Ser Tyr His Glu
705                 710                 715                 720 
Val Thr Thr Val Lys Lys Glu Glu Val Ile His Gly Asp Val Arg Gly
                725                 730                 735     
Thr Arg Trp Leu Phe Glu Thr Lys Pro Leu Asp Ser Ile Asn Lys Ser
            740                 745                 750         
Glu Thr Val Tyr Val Ile Lys Ser Val Thr Gln Glu Asp Ile Gln Lys
        755                 760                 765             
Gly Asp Val Ser Ser Val Arg Tyr Arg Phe Glu Thr Gln Pro Leu Asp
    770                 775                 780                 
Gln Ile Ser Glu Glu Ser His Asn Ile Met Pro Ser Ile Asp His Ile
785                 790                 795                 800 
Gln Gly Gly Asn Val Lys Thr Ser Arg Gln Phe Phe Glu Ser Glu Asn
                805                 810                 815     
Phe Asp Lys Asn Asn Tyr Ile Arg Thr Val Ser Val Asn Glu Ile Gln
            820                 825                 830         
Lys Gly Asn Val Lys Thr Ser Thr Trp Leu Phe Glu Thr His Thr Met
        835                 840                 845             
Asp Glu Leu Arg Gly Glu Gly Leu Glu Tyr Glu Asn Ile Lys Thr Val
    850                 855                 860                 
Thr Gln Glu Asp Val Gln Lys Gly Asp Val Lys Gln Ala Val Trp Leu
865                 870                 875                 880 
Phe Glu Asn Arg Thr Phe Asp Ser Ile Met Glu Ala His Lys Gly Ile
                885                 890                 895     
Thr Lys Met Thr Lys Glu Glu Ile Pro Pro Ser Asp Val Lys Thr Thr
            900                 905                 910         
Thr Trp Leu Phe Glu Thr Thr Pro Leu His Glu Phe Asn Glu Thr Arg
        915                 920                 925             
Val Glu Lys Ile Glu Ile Ile Gly Lys Ser Ile Lys Glu Thr Leu Glu
    930                 935                 940                 
Asp Leu Tyr Ser Gln Lys Val Ile Gln Ala Pro Gly Ile Ile Ile Glu
945                 950                 955                 960 
Ala Asp Glu Ile Gly Asp Val Arg Met Ala Lys Tyr Lys Leu Met Asn
                965                 970                 975     
Gln Ala Ser Pro Glu Ile Gln Lys Glu Glu Ile Ile Arg Ala Asp Leu
            980                 985                 990         
Arg Asn Ile Met Val Asn Leu Leu Ser Lys Arg Asp Cys Thr Glu Arg
        995                 1000                1005            
Glu Ile Leu Ile Ser Glu Glu Glu Lys Gly Asn Val Asn Leu Thr Lys
    1010                1015                1020                
Thr Gln Leu Leu Asn Arg Ser Thr Glu Phe His Ala Glu Lys Glu Glu
1025                1030                1035                1040
Ile Val Lys Gly Asp Val Gln Gln Ala Ile Lys Asn Leu Phe Ser Glu
                1045                1050                1055    
Glu Arg Ser Val Lys Lys Gly Ile Leu Ile Gln Glu Asp Glu Lys Gly
            1060                1065                1070        
Asp Ile Asn Met Thr Ile Tyr Cys Leu Leu His Glu Asn Asp Gly Asp
        1075                1080                1085            
Thr Ile Glu Arg Glu Glu Val Ile Gly Gly Asp Val Lys Arg Thr Ile
    1090                1095                1100                
His Asn Leu Leu Ser Ser Thr Ser Asn Asn Lys Ile Ser Glu Arg Ala
1105                1110                1115                1120
Lys Ile Asp Ala Ser Glu Arg Gly Asn Val Gln Phe Phe Thr Thr Cys
                1125                1130                1135    
Ile Glu Ala Gly Ala Leu Asp Tyr Leu Lys Gln Leu His Thr Glu Ser
            1140                1145                1150        
Asn Glu Thr Leu Thr Ala Lys Lys Gln Glu Gly Glu Lys Glu Ile Ile
        1155                1160                1165            
Gly Gly Asp Val Glu Gly Thr Lys Leu Leu Leu Lys Lys Arg Gln Ser
    1170                1175                1180                
Leu Val Glu Arg Thr Val Ser Glu Thr Asp Ile Ile Pro Gly Asp Val
1185                1190                1195                1200
His Asn Thr Val Lys Val Phe Met Thr Glu Pro Gln Ser Thr Phe Gly
                1205                1210                1215    
Lys Ile Pro Lys Glu Glu Ile Ile Lys Gly Asp Leu Thr Ser Thr Leu
            1220                1225                1230        
Asn Ser Leu Ser Gln Ala Val Asn Gln Lys Thr Val Thr Lys Thr Glu
        1235                1240                1245            
Glu Ile Ile Lys Gly Asn Met Leu Ala Thr Leu Lys Ser Leu Lys Glu
    1250                1255                1260                
Ser Ser His Arg Trp Lys Glu Ser Lys Gln Pro Asp Ala Ile Pro Gly
1265                1270                1275                1280
Asp Ile Glu Lys Ala Ile Glu Cys Leu Glu Lys Ala Thr Asn Thr Lys
                1285                1290                1295    
Thr Glu Ile Leu Lys Lys Glu Leu Leu Lys Asp Asp Leu Glu Thr Ser
            1300                1305                1310        
Leu Arg Ser Leu Lys Glu Ala Gln Arg Ser Phe Lys Glu Val His Lys
        1315                1320                1325            
Glu Gly Val Ile Lys Lys Asp Ala Lys Ala Val Met Ala Gly Ser Ser
    1330                1335                1340                
Gly Glu Gln Lys Thr Asp Ile His Gln Val Ala Val Gln Arg Asn Lys
1345                1350                1355                1360
Asn Ser Leu Leu Gln Pro Lys Pro Gly Pro Phe Glu Pro Ala Ala Lys
                1365                1370                1375    
Trp Gln Gly Gly Ala Asp Thr Leu Ser Gln Thr Met Gly Lys Ser Cys
            1380                1385                1390        
His Gly Asn Leu Val Glu Glu Arg Thr Glu Val Asn Leu Pro Lys Ala
        1395                1400                1405            
Pro Lys Gly Thr Val Lys Ile Val Ile Asp Arg Glu Gln Asn Asn Asp
    1410                1415                1420                
Ala Leu Glu Lys Ser Leu Arg Arg Leu Ser Asn Ser His His Lys Ser
1425                1430                1435                1440
Asn Val Leu Glu Ser Gly Asp Lys Thr Gly Val Trp Thr Asp Thr Thr
                1445                1450                1455    
Gly Glu Gln His Leu Arg Asp Glu Tyr Met Ser Arg Gln Leu Thr Ser
            1460                1465                1470        
Thr Val Ser Val Lys Asn Asn Leu Thr Thr Lys Glu Ser Asp Arg Ala
        1475                1480                1485            
Val Arg Glu Leu Lys Lys Asp Asp Val Phe Asn Ser Ile Gln Ser Ala
    1490                1495                1500                
Gly Lys Thr Val Gly Lys Gln Gln Thr Tyr Glu Leu Arg Asn Asp His
1505                1510                1515                1520
Gln Lys Met Glu Gly Phe His Ile Lys Ser Pro Lys Lys Thr Lys Asn
                1525                1530                1535    
Ile Lys Ile Leu Thr Asp Thr Gln Ser Ser Lys Pro Ser Pro Thr Gln
            1540                1545                1550        
His Pro Val Ser Met Pro Val Gly Gly Thr Tyr Asp Leu Ser Gly Asp
        1555                1560                1565            
Phe Gln Lys Gln Thr Leu Leu Lys Gln Glu Thr Lys Tyr Ser Asn Lys
    1570                1575                1580                
Asp Ile Lys Lys Lys Asn Ile Asn Leu Gln Pro Met Trp Gln Leu Leu
1585                1590                1595                1600
Pro Val Glu Gln Asp Thr Ser Asn Val Thr Glu Met Lys Val Ser Glu
                1605                1610                1615    
Lys Ser His Asn Thr Phe Lys Ala Thr Asn Lys Lys Arg Glu Thr Asp
            1620                1625                1630        
Val His Leu Lys Ser Gln Asp Phe Leu Met Lys Thr Asn Thr Ser Thr
        1635                1640                1645            
Gly Leu Lys Met Ala Met Glu Arg Ser Leu Asn Pro Ile Asn Phe Asn
    1650                1655                1660                
Pro Glu Asn Asn Val Lys Glu Ser Glu Cys Pro Leu Pro Pro Pro Ser
1665                1670                1675                1680
Pro Pro Pro Pro Pro Pro Ser Asn Ala Ser Ser Glu Ile Glu Phe Pro
                1685                1690                1695    
Leu Pro Pro Pro Pro Pro Leu Met Met Phe Pro Glu Lys Asn Gly Phe
            1700                1705                1710        
Leu Pro Ser Leu Ser Thr Glu Lys Ile Lys Ala Glu Phe Glu Ser Phe
        1715                1720                1725            
Pro Gly Leu Pro Leu Pro Pro Pro Pro Val Asp Glu Lys Ser Glu Arg
    1730                1735                1740                
Glu Ser Ser Ser Met Phe Leu Pro Pro Pro Pro Pro Pro Thr Pro Ser
1745                1750                1755                1760
Gln Lys Pro Ala His Leu Leu Ser Ser Ser Ala Pro Glu Lys His Ser
                1765                1770                1775    
Gly Asp Phe Met Gln Gln Tyr Ser Gln Lys Glu Ala Ser Asn Ser Gln
            1780                1785                1790        
Asn Ser Gln Ala Lys Ile Ile Thr Gly Lys Thr Gly Val Leu Pro Pro
        1795                1800                1805            
Pro Thr Leu Pro Lys Pro Lys Leu Pro Lys His Ile Lys Asp Asn Lys
    1810                1815                1820                
Asn Asp Phe Ser Pro Lys Val Glu Leu Ala Thr Ser Leu Ser Asp Met
1825                1830                1835                1840
Glu Cys Lys Ile Thr Thr Ser Lys Asp Gln Lys Lys Val Met Val Met
                1845                1850                1855    
Thr Ser Ser Glu His Thr Glu Thr Lys Gln Asn Val Ile Ser Lys Ser
            1860                1865                1870        
Leu Asp Glu Arg Lys Gln Leu Ser Ile Asp Ser Ala Asn Cys Leu Ser
        1875                1880                1885            
His Thr Val Pro Gly Thr Ser Ala Pro Arg Lys Lys Gln Ile Ala Pro
    1890                1895                1900                
Leu Ile Lys Ser His Ser Phe Pro Glu Ser Ser Gly Gln Gln Asn Pro
1905                1910                1915                1920
Lys Pro Tyr Met Arg Lys Phe Lys Thr Pro Leu Met Ile Ala Glu Glu
                1925                1930                1935    
Lys Tyr Arg Gln Gln Lys Lys Lys Lys Lys
            1940                1945    


<210> 8423
<211> 201
<212> PRT
<213> Homo sapiens

<400> 8423
Met Pro Ser Glu Thr Leu Trp Glu Ile Ala Lys Ala Glu Val Glu Lys
 1               5                  10                  15      
Arg Gly Ile Asn Gly Ser Glu Gly Asp Gly Ala Glu Ile Ala Glu Lys
            20                  25                  30          
Phe Val Phe Phe Ile Gly Ser Lys Asn Gly Gly Lys Thr Thr Ile Ile
        35                  40                  45              
Leu Arg Cys Leu Asp Arg Asp Glu Pro Pro Lys Pro Thr Leu Ala Leu
    50                  55                  60                  
Glu Tyr Thr Tyr Gly Arg Arg Ala Lys Gly His Asn Thr Pro Lys Asp
65                  70                  75                  80  
Ile Ala His Phe Trp Glu Leu Gly Gly Gly Thr Ser Leu Leu Asp Leu
                85                  90                  95      
Ile Ser Ile Pro Ile Thr Gly Asp Thr Leu Arg Thr Phe Ser Leu Val
            100                 105                 110         
Leu Val Leu Asp Leu Ser Lys Pro Asn Asp Leu Trp Pro Thr Met Glu
        115                 120                 125             
Asn Leu Leu Gln Ala Thr Lys Ser His Val Asp Lys Val Ile Met Lys
    130                 135                 140                 
Leu Gly Lys Thr Asn Ala Lys Ala Val Ser Glu Met Arg Gln Lys Ile
145                 150                 155                 160 
Trp Asn Asn Met Pro Lys Asp His Pro Val Ser Cys Cys Leu Gly Leu
                165                 170                 175     
Leu Leu Glu Ser Leu Val Pro Phe Ile Val Asn Asp Asn Ile Thr Asn
            180                 185                 190         
Asn Phe Phe Arg Phe Leu Cys Met Thr
        195                 200     


<210> 8424
<211> 262
<212> PRT
<213> Homo sapiens

<400> 8424
Met Leu Glu Pro Ser Ala Asn Met Pro Trp Phe Lys Gly Trp Lys Val
 1               5                  10                  15      
Thr His Lys Asp Gly Asn Ala Ser Gly Thr Met Leu Leu Glu Ala Leu
            20                  25                  30          
Asp Cys Ile Leu Pro Pro Thr Arg Pro Thr Asp Lys Pro Leu Arg Leu
        35                  40                  45              
Pro Leu Gln Asp Val Tyr Lys Ile Gly Gly Ile Gly Thr Val Leu Val
    50                  55                  60                  
Gly Arg Val Glu Thr Gly Ile Leu Lys Pro Gly Met Val Val Thr Phe
65                  70                  75                  80  
Ala Pro Val Ser Val Thr Thr Glu Val Lys Ser Val Glu Met His His
                85                  90                  95      
Glu Ala Leu Asn Glu Ala Leu Pro Gly Asp Asn Met Gly Phe Asn Val
            100                 105                 110         
Lys Asn Val Ser Val Lys Asp Val His Arg Gly Asn Val Ala Gly Asp
        115                 120                 125             
Ser Lys Asn Asp Pro Pro Met Glu Ala Ala Gly Phe Thr Ala Gln Val
    130                 135                 140                 
Ile Ile Leu Asn His Pro Gly Gln Ile Ser Ser Gly Tyr Ala Pro Val
145                 150                 155                 160 
Leu Asp Cys His Thr Ala His Ile Ala Cys Lys Phe Ala Glu Leu Lys
                165                 170                 175     
Glu Lys Ile Asp Arg Arg Ser Gly Lys Lys Leu Glu Asp Gly Pro Lys
            180                 185                 190         
Phe Leu Lys Ser Gly Asp Ala Ala Ile Ala Asp Met Val Pro Gly Lys
        195                 200                 205             
Pro Met Cys Val Glu Ser Phe Ser Asp Tyr Pro Pro Leu Gly Arg Phe
    210                 215                 220                 
Thr Val His Asp Met Arg Gln Thr Leu Ala Val Gly Val Ile Lys Ala
225                 230                 235                 240 
Val Asp Lys Lys Ala Ala Gly Ala Gly Lys Val Thr Lys Ser Ala Gln
                245                 250                 255     
Lys Ala Gln Lys Ala Lys
            260         


<210> 8425
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8425
Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val
 1               5                  10                  15      
Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Ser
            20                  25                  30          
Ser Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Thr Ala Glu
        35                  40                  45              
Met Gly Lys Gly Ser Phe Lys Tyr Gly Trp Val Leu Asp Lys Leu Lys
    50                  55                  60                  
Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe
65                  70                  75                  80  
Glu Thr Ser Lys Tyr Tyr Val Thr Ile Thr Asp Ala Pro Gly His Arg
                85                  90                  95      
Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala
            100                 105                 110         
Val Pro Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser
        115                 120                 125             
Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly
    130                 135                 140                 
Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro
145                 150                 155                 160 
Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr
                165                 170                 175     
Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro
            180                 185                 190         
Ile Ser Gly Trp Asn Gly Asn Asn Met Leu Glu Pro Ser Ala Asn Met
        195                 200                 205             
Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser
    210                 215                 220                 
Gly Thr Met Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg
225                 230                 235                 240 
Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile
                245                 250                 255     
Gly Gly Ile Gly Ser Val Pro Val Gly Arg Val Glu Thr Gly Ile Leu
            260                 265                 270         
Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu
        275                 280                 285             
Val Lys Ser Val Glu Met His His Glu Ala Leu Gly Glu Ala Leu Pro
    290                 295                 300                 
Gly Asp Ser Val Gly Phe His Val Lys Asn Val Ser Val Lys Asp Val
305                 310                 315                 320 
Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu
                325                 330                 335     
Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln
            340                 345                 350         
Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile
        355                 360                 365             
Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly
    370                 375                 380                 
Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala
385                 390                 395                 400 
Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Ala Glu Ser Phe Ser
                405                 410                 415     
Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg His Thr
            420                 425                 430         
Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala
        435                 440                 445             
Gly Lys Val Thr Asn Ser Ala Gln Lys Ala Gln Met Ala Lys
    450                 455                 460         


<210> 8426
<211> 627
<212> PRT
<213> Homo sapiens

<400> 8426
Met Ala Ala Ala Val Leu Thr Asp Arg Ala Gln Val Ser Val Thr Phe
 1               5                  10                  15      
Asp Asp Val Ala Val Thr Phe Thr Lys Glu Glu Trp Gly Gln Leu Asp
            20                  25                  30          
Leu Ala Gln Arg Thr Leu Tyr Gln Glu Val Met Leu Glu Asn Cys Gly
        35                  40                  45              
Leu Leu Val Ser Leu Gly Cys Pro Val Pro Lys Ala Glu Leu Ile Cys
    50                  55                  60                  
His Leu Glu His Gly Gln Glu Pro Trp Thr Arg Lys Glu Asp Leu Ser
65                  70                  75                  80  
Gln Asp Thr Cys Pro Gly Asp Lys Gly Lys Pro Lys Thr Thr Glu Pro
                85                  90                  95      
Thr Thr Cys Glu Pro Ala Leu Ser Glu Gly Ile Ser Leu Gln Gly Gln
            100                 105                 110         
Val Thr Gln Gly Asn Ser Val Asp Ser Gln Leu Gly Gln Ala Glu Asp
        115                 120                 125             
Gln Asp Gly Leu Ser Glu Met Gln Glu Gly His Phe Arg Pro Gly Ile
    130                 135                 140                 
Asp Pro Gln Glu Lys Ser Pro Gly Lys Met Ser Pro Glu Cys Asp Gly
145                 150                 155                 160 
Leu Gly Thr Ala Asp Gly Val Cys Ser Arg Ile Gly Gln Glu Gln Val
                165                 170                 175     
Ser Pro Gly Asp Arg Val Arg Ser His Asn Ser Cys Glu Ser Gly Lys
            180                 185                 190         
Asp Pro Met Ile Gln Glu Glu Glu Asn Asn Phe Lys Cys Ser Glu Cys
        195                 200                 205             
Gly Lys Val Phe Asn Lys Lys His Leu Leu Ala Gly His Glu Lys Ile
    210                 215                 220                 
His Ser Gly Val Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Thr Phe
225                 230                 235                 240 
Ile Lys Ser Thr His Leu Leu Gln His His Met Ile His Thr Gly Glu
                245                 250                 255     
Arg Pro Tyr Glu Cys Met Glu Cys Gly Lys Ala Phe Asn Arg Lys Ser
            260                 265                 270         
Tyr Leu Thr Gln His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Lys
        275                 280                 285             
Cys Asn Glu Cys Gly Lys Ala Phe Thr His Arg Ser Asn Phe Val Leu
    290                 295                 300                 
His Asn Arg Arg His Thr Gly Glu Lys Ser Phe Val Cys Thr Glu Cys
305                 310                 315                 320 
Gly Gln Val Phe Arg His Arg Pro Gly Phe Leu Arg His Tyr Val Val
                325                 330                 335     
His Ser Gly Glu Asn Pro Tyr Glu Cys Leu Glu Cys Gly Lys Val Phe
            340                 345                 350         
Lys His Arg Ser Tyr Leu Met Trp His Gln Gln Thr His Thr Gly Glu
        355                 360                 365             
Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Val Phe Leu Glu Ser Ala
    370                 375                 380                 
Ala Leu Ile His His Tyr Val Ile His Thr Gly Glu Lys Pro Phe Glu
385                 390                 395                 400 
Cys Leu Glu Cys Gly Lys Ala Phe Asn His Arg Ser Tyr Leu Lys Arg
                405                 410                 415     
His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Val Cys Ser Glu Cys
            420                 425                 430         
Gly Lys Ala Phe Thr His Cys Ser Thr Phe Ile Leu His Lys Arg Ala
        435                 440                 445             
His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe
    450                 455                 460                 
Ser Asn Arg Lys Asp Leu Ile Arg His Phe Ser Ile His Thr Gly Glu
465                 470                 475                 480 
Lys Pro Tyr Glu Cys Val Glu Cys Gly Lys Ala Phe Thr Arg Met Ser
                485                 490                 495     
Gly Leu Thr Arg His Lys Arg Ile His Ser Gly Glu Lys Pro Tyr Glu
            500                 505                 510         
Cys Val Glu Cys Gly Lys Ser Phe Cys Trp Ser Thr Asn Leu Ile Arg
        515                 520                 525             
His Ala Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys
    530                 535                 540                 
Gly Lys Ala Phe Ser Arg Ser Ser Ser Leu Thr Gln His Gln Arg Met
545                 550                 555                 560 
His Thr Gly Lys Asn Pro Ile Ser Val Thr Asp Val Gly Arg Pro Phe
                565                 570                 575     
Thr Ser Gly Gln Thr Ser Val Thr Leu Arg Glu Leu Leu Leu Gly Lys
            580                 585                 590         
Asp Phe Leu Asn Val Thr Thr Glu Ala Asn Ile Leu Pro Glu Glu Thr
        595                 600                 605             
Ser Ser Ser Ala Ser Asp Gln Pro Tyr Gln Arg Glu Thr Pro Gln Val
    610                 615                 620                 
Ser Ser Leu
625         


<210> 8427
<211> 1515
<212> PRT
<213> Homo sapiens

<400> 8427
Met Ser Leu Leu Thr Cys Ala Phe Tyr Leu Gly Tyr Glu Leu Gln Phe
 1               5                  10                  15      
Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr Asn
            20                  25                  30          
Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser Leu
        35                  40                  45              
Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr Cys
    50                  55                  60                  
Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu Gln
65                  70                  75                  80  
Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile Leu
                85                  90                  95      
Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr Leu
            100                 105                 110         
Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu Ser
        115                 120                 125             
Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe Thr
    130                 135                 140                 
Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala Asn
145                 150                 155                 160 
Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr Thr
                165                 170                 175     
Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp Asn
            180                 185                 190         
Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn Ser
        195                 200                 205             
Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn Ser
    210                 215                 220                 
Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg Phe
225                 230                 235                 240 
Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro Ala
                245                 250                 255     
Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile Trp
            260                 265                 270         
Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val Asp
        275                 280                 285             
Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu Asn
    290                 295                 300                 
Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile Gln
305                 310                 315                 320 
Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile Ala
                325                 330                 335     
Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu Glu
            340                 345                 350         
Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu Lys
        355                 360                 365             
His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu Leu
    370                 375                 380                 
Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu Gly
385                 390                 395                 400 
Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe Pro
                405                 410                 415     
Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu Pro
            420                 425                 430         
Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly Asp
        435                 440                 445             
Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu Arg
    450                 455                 460                 
Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly Asn
465                 470                 475                 480 
Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr Thr
                485                 490                 495     
Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys His
            500                 505                 510         
Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg Asn
        515                 520                 525             
Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser Glu
    530                 535                 540                 
Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu Ile
545                 550                 555                 560 
Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu Val
                565                 570                 575     
Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys Leu
            580                 585                 590         
Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile Thr
        595                 600                 605             
His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala Leu
    610                 615                 620                 
Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser Thr
625                 630                 635                 640 
Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser Glu
                645                 650                 655     
Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn Thr
            660                 665                 670         
Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala Ile
        675                 680                 685             
Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val Tyr
    690                 695                 700                 
Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser Pro
705                 710                 715                 720 
Ser Ile His Gln Ser Val Val Ala Val Ser Arg Thr Ala Phe Arg Asn
                725                 730                 735     
Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile Pro
            740                 745                 750         
Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg Asn
        755                 760                 765             
Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro Asp
    770                 775                 780                 
Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys Ile
785                 790                 795                 800 
Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile Gln
                805                 810                 815     
Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe Arg
            820                 825                 830         
Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg Asn
        835                 840                 845             
His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala Val
    850                 855                 860                 
Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala Ser
865                 870                 875                 880 
Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu Ser
                885                 890                 895     
Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp Ser
            900                 905                 910         
Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala Glu
        915                 920                 925             
Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu Arg
    930                 935                 940                 
Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser Arg
945                 950                 955                 960 
Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe Phe
                965                 970                 975     
Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp Ala
            980                 985                 990         
Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys Gln
        995                 1000                1005            
Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe Val Lys His Leu Ser
    1010                1015                1020                
Leu Gly Ser Val Gln Leu Cys Gly Val Gly Lys Phe Pro Ser Leu Pro
1025                1030                1035                1040
Ile Leu Ser Pro Ala Leu Met Asp Val Pro Tyr Arg Leu Asn Glu Ile
                1045                1050                1055    
Thr Lys Glu Lys Glu Gln Cys Cys Val Ser Leu Ala Ala Gly Leu Pro
            1060                1065                1070        
His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr Phe Ile
        1075                1080                1085            
Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly Arg Tyr Val Glu Ala Arg
    1090                1095                1100                
Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu Arg His Gly Leu Ile Pro
1105                1110                1115                1120
Asn Leu Leu Gly Glu Gly Ile Tyr Ala Arg Tyr Asn Cys Arg Asp Ala
                1125                1130                1135    
Val Trp Trp Trp Leu Gln Cys Ile Gln Asp Tyr Cys Lys Met Val Pro
            1140                1145                1150        
Asn Gly Leu Asp Ile Leu Lys Cys Pro Val Ser Arg Met Tyr Pro Thr
        1155                1160                1165            
Asp Asp Ser Ala Pro Leu Pro Ala Gly Thr Leu Asp Gln Pro Leu Phe
    1170                1175                1180                
Glu Val Ile Gln Glu Ala Met Gln Lys His Met Gln Gly Ile Gln Phe
1185                1190                1195                1200
Arg Glu Arg Asn Ala Gly Pro Gln Ile Asp Arg Asn Met Lys Asp Glu
                1205                1210                1215    
Gly Phe Asn Ile Thr Ala Gly Val Asp Glu Glu Thr Gly Phe Val Tyr
            1220                1225                1230        
Gly Gly Asn Arg Phe Asn Cys Gly Thr Trp Met Asp Lys Met Gly Glu
        1235                1240                1245            
Ser Asp Arg Ala Arg Asn Arg Gly Ile Pro Ala Thr Pro Arg Asp Gly
    1250                1255                1260                
Ser Ala Val Glu Ile Val Gly Leu Ser Lys Ser Ala Val Arg Trp Leu
1265                1270                1275                1280
Leu Glu Leu Ser Lys Lys Asn Ile Phe Pro Tyr His Glu Val Thr Val
                1285                1290                1295    
Lys Arg His Gly Lys Ala Ile Lys Val Ser Tyr Asp Glu Trp Asn Arg
            1300                1305                1310        
Lys Ile Gln Asp Asn Phe Glu Lys Leu Phe His Val Ser Glu Asp Pro
        1315                1320                1325            
Ser Asp Leu Asn Glu Lys His Pro Asn Leu Val His Lys Arg Gly Ile
    1330                1335                1340                
Tyr Lys Asp Ser Tyr Gly Ala Ser Ser Pro Trp Cys Asp Tyr Gln Leu
1345                1350                1355                1360
Arg Pro Asn Phe Thr Ile Ala Met Val Val Ala Pro Glu Leu Phe Thr
                1365                1370                1375    
Thr Glu Lys Ala Gly Lys Ala Leu Glu Ile Ala Glu Lys Lys Leu Leu
            1380                1385                1390        
Gly Pro Leu Gly Met Lys Thr Leu Asp Pro Asp Asp Met Val Tyr Cys
        1395                1400                1405            
Gly Ile Tyr Asp Asn Ala Leu Asp Asn Asp Asn Tyr Asn Leu Ala Lys
    1410                1415                1420                
Gly Phe Asn Tyr His Gln Gly Pro Glu Trp Leu Trp Pro Ile Gly Tyr
1425                1430                1435                1440
Phe Leu Arg Ala Lys Leu Tyr Phe Ser Arg Leu Met Gly Pro Glu Thr
                1445                1450                1455    
Thr Ala Lys Thr Ile Val Leu Val Lys Asn Val Leu Ser Arg His Tyr
            1460                1465                1470        
Val His Leu Glu Arg Ser Pro Trp Lys Gly Leu Pro Glu Leu Thr Asn
        1475                1480                1485            
Glu Asn Ala Gln Tyr Cys Pro Phe Ser Cys Glu Thr Gln Ala Trp Ser
    1490                1495                1500                
Ile Ala Thr Ile Leu Glu Thr Leu Tyr Asp Leu
1505                1510                1515


<210> 8428
<211> 1516
<212> PRT
<213> Homo sapiens

<400> 8428
Met Ala Pro Leu Leu Ser Ile Asn Leu Phe Ile Gly Tyr Glu Leu Gln
 1               5                  10                  15      
Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr
            20                  25                  30          
Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser
        35                  40                  45              
Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr
    50                  55                  60                  
Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu
65                  70                  75                  80  
Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile
                85                  90                  95      
Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr
            100                 105                 110         
Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu
        115                 120                 125             
Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe
    130                 135                 140                 
Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala
145                 150                 155                 160 
Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr
                165                 170                 175     
Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp
            180                 185                 190         
Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn
        195                 200                 205             
Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn
    210                 215                 220                 
Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg
225                 230                 235                 240 
Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro
                245                 250                 255     
Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile
            260                 265                 270         
Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val
        275                 280                 285             
Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu
    290                 295                 300                 
Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile
305                 310                 315                 320 
Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile
                325                 330                 335     
Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu
            340                 345                 350         
Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu
        355                 360                 365             
Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu
    370                 375                 380                 
Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu
385                 390                 395                 400 
Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe
                405                 410                 415     
Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu
            420                 425                 430         
Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly
        435                 440                 445             
Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu
    450                 455                 460                 
Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly
465                 470                 475                 480 
Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr
                485                 490                 495     
Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys
            500                 505                 510         
His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg
        515                 520                 525             
Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser
    530                 535                 540                 
Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu
545                 550                 555                 560 
Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu
                565                 570                 575     
Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys
            580                 585                 590         
Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile
        595                 600                 605             
Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala
    610                 615                 620                 
Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser
625                 630                 635                 640 
Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser
                645                 650                 655     
Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn
            660                 665                 670         
Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala
        675                 680                 685             
Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Gly Phe Ile Gln Val
    690                 695                 700                 
Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr Arg His Ser
705                 710                 715                 720 
Pro Ser Ile His Gln Ser Val Val Ala Val Ser Arg Thr Ala Phe Arg
                725                 730                 735     
Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln Met Cys Ile
            740                 745                 750         
Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr Ile Glu Arg
        755                 760                 765             
Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn Gly Thr Pro
    770                 775                 780                 
Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn Glu Ser Lys
785                 790                 795                 800 
Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn Glu Tyr Ile
                805                 810                 815     
Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val Ile Ile Phe
            820                 825                 830         
Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly Ile Leu Arg
        835                 840                 845             
Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly Ser Leu Ala
    850                 855                 860                 
Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala Ser Leu Ala
865                 870                 875                 880 
Ser Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr Arg Cys Glu
                885                 890                 895     
Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile Pro Asn Trp
            900                 905                 910         
Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser Val Leu Ala
        915                 920                 925             
Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys Asn Asn Leu
    930                 935                 940                 
Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg Leu Ile Ser
945                 950                 955                 960 
Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln Ala Met Phe
                965                 970                 975     
Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys Tyr Phe Asp
            980                 985                 990         
Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Thr Ala Trp Lys
        995                 1000                1005            
Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe Val Lys His Leu
    1010                1015                1020                
Ser Leu Gly Ser Val Gln Leu Cys Gly Val Gly Lys Phe Pro Ser Leu
1025                1030                1035                1040
Pro Ile Leu Ser Pro Ala Leu Met Asp Val Pro Tyr Arg Leu Asn Glu
                1045                1050                1055    
Ile Thr Lys Glu Lys Glu Gln Cys Cys Val Ser Leu Ala Ala Gly Leu
            1060                1065                1070        
Pro His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg Asp Thr Phe
        1075                1080                1085            
Ile Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly Arg Tyr Val Glu Ala
    1090                1095                1100                
Arg Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu Arg His Gly Leu Ile
1105                1110                1115                1120
Pro Asn Leu Leu Gly Glu Gly Ile Tyr Ala Arg Tyr Asn Cys Arg Asp
                1125                1130                1135    
Ala Val Trp Trp Trp Leu Gln Cys Ile Gln Asp Tyr Cys Lys Met Val
            1140                1145                1150        
Pro Asn Gly Leu Asp Ile Leu Lys Cys Pro Val Ser Arg Met Tyr Pro
        1155                1160                1165            
Thr Asp Asp Ser Ala Pro Leu Pro Ala Gly Thr Leu Asp Gln Pro Leu
    1170                1175                1180                
Phe Glu Val Ile Gln Glu Ala Met Gln Lys His Met Gln Gly Ile Gln
1185                1190                1195                1200
Phe Arg Glu Arg Asn Ala Gly Pro Gln Ile Asp Arg Asn Met Lys Asp
                1205                1210                1215    
Glu Gly Phe Asn Ile Thr Ala Gly Val Asp Glu Glu Thr Gly Phe Val
            1220                1225                1230        
Tyr Gly Gly Asn Arg Phe Asn Cys Gly Thr Trp Met Asp Lys Met Gly
        1235                1240                1245            
Glu Ser Asp Arg Ala Arg Asn Arg Gly Ile Pro Ala Thr Pro Arg Asp
    1250                1255                1260                
Gly Ser Ala Val Glu Ile Val Gly Leu Ser Lys Ser Ala Val Arg Trp
1265                1270                1275                1280
Leu Leu Glu Leu Ser Lys Lys Asn Ile Phe Pro Tyr His Glu Val Thr
                1285                1290                1295    
Val Lys Arg His Gly Lys Ala Ile Lys Val Ser Tyr Asp Glu Trp Asn
            1300                1305                1310        
Arg Lys Ile Gln Asp Asn Phe Glu Lys Leu Phe His Val Ser Glu Asp
        1315                1320                1325            
Pro Ser Asp Leu Asn Glu Lys His Pro Asn Leu Val His Lys Arg Gly
    1330                1335                1340                
Ile Tyr Lys Asp Ser Tyr Gly Ala Ser Ser Pro Trp Cys Asp Tyr Gln
1345                1350                1355                1360
Leu Arg Pro Asn Phe Thr Ile Ala Met Val Val Ala Pro Glu Leu Phe
                1365                1370                1375    
Thr Thr Glu Lys Ala Gly Lys Ala Leu Glu Ile Ala Glu Lys Lys Leu
            1380                1385                1390        
Leu Gly Pro Leu Gly Met Lys Thr Leu Asp Pro Asp Asp Met Val Tyr
        1395                1400                1405            
Cys Gly Ile Tyr Asp Asn Ala Leu Asp Asn Asp Asn Tyr Asn Leu Ala
    1410                1415                1420                
Lys Gly Phe Asn Tyr His Gln Gly Pro Glu Trp Leu Trp Pro Ile Gly
1425                1430                1435                1440
Tyr Phe Leu Arg Ala Lys Leu Tyr Phe Ser Arg Leu Met Gly Pro Glu
                1445                1450                1455    
Thr Thr Ala Lys Thr Ile Val Leu Val Lys Asn Val Leu Ser Arg His
            1460                1465                1470        
Tyr Val His Leu Glu Arg Ser Pro Trp Lys Gly Leu Pro Glu Leu Thr
        1475                1480                1485            
Asn Glu Asn Ala Gln Tyr Cys Pro Phe Ser Cys Glu Thr Gln Ala Trp
    1490                1495                1500                
Ser Ile Ala Thr Ile Leu Glu Thr Leu Tyr Asp Leu
1505                1510                1515    


<210> 8429
<211> 1535
<212> PRT
<213> Homo sapiens

<400> 8429
Met Gly His Ser Lys Gln Ile Arg Ile Leu Leu Leu Asn Glu Met Glu
 1               5                  10                  15      
Lys Leu Glu Lys Thr Leu Phe Arg Leu Glu Gln Gly Tyr Glu Leu Gln
            20                  25                  30          
Phe Arg Leu Gly Pro Thr Leu Gln Gly Lys Ala Val Thr Val Tyr Thr
        35                  40                  45              
Asn Tyr Pro Phe Pro Gly Glu Thr Phe Asn Arg Glu Lys Phe Arg Ser
    50                  55                  60                  
Leu Asp Trp Glu Asn Pro Thr Glu Arg Glu Asp Asp Ser Asp Lys Tyr
65                  70                  75                  80  
Cys Lys Leu Asn Leu Gln Gln Ser Gly Ser Phe Gln Tyr Tyr Phe Leu
                85                  90                  95      
Gln Gly Asn Glu Lys Ser Gly Gly Gly Tyr Ile Val Val Asp Pro Ile
            100                 105                 110         
Leu Arg Val Gly Ala Asp Asn His Val Leu Pro Leu Asp Cys Val Thr
        115                 120                 125             
Leu Gln Thr Phe Leu Ala Lys Cys Leu Gly Pro Phe Asp Glu Trp Glu
    130                 135                 140                 
Ser Arg Leu Arg Val Ala Lys Glu Ser Gly Tyr Asn Met Ile His Phe
145                 150                 155                 160 
Thr Pro Leu Gln Thr Leu Gly Leu Ser Arg Ser Cys Tyr Ser Leu Ala
                165                 170                 175     
Asn Gln Leu Glu Leu Asn Pro Asp Phe Ser Arg Pro Asn Arg Lys Tyr
            180                 185                 190         
Thr Trp Asn Asp Val Gly Gln Leu Val Glu Lys Leu Lys Lys Glu Trp
        195                 200                 205             
Asn Val Ile Cys Ile Thr Asp Val Val Tyr Asn His Thr Ala Ala Asn
    210                 215                 220                 
Ser Lys Trp Ile Gln Glu His Pro Glu Cys Ala Tyr Asn Leu Val Asn
225                 230                 235                 240 
Ser Pro His Leu Lys Pro Ala Trp Val Leu Asp Arg Ala Leu Trp Arg
                245                 250                 255     
Phe Ser Cys Asp Val Ala Glu Gly Lys Tyr Lys Glu Lys Gly Ile Pro
            260                 265                 270         
Ala Leu Ile Glu Asn Asp His His Met Asn Ser Ile Arg Lys Ile Ile
        275                 280                 285             
Trp Glu Asp Ile Phe Pro Lys Leu Lys Leu Trp Glu Phe Phe Gln Val
    290                 295                 300                 
Asp Val Asn Lys Ala Val Glu Gln Phe Arg Arg Leu Leu Thr Gln Glu
305                 310                 315                 320 
Asn Arg Arg Val Thr Lys Ser Asp Pro Asn Gln His Leu Thr Ile Ile
                325                 330                 335     
Gln Asp Pro Glu Tyr Arg Arg Phe Gly Cys Thr Val Asp Met Asn Ile
            340                 345                 350         
Ala Leu Thr Thr Phe Ile Pro His Asp Lys Gly Pro Ala Ala Ile Glu
        355                 360                 365             
Glu Cys Cys Asn Trp Phe His Lys Arg Met Glu Glu Leu Asn Ser Glu
    370                 375                 380                 
Lys His Arg Leu Ile Asn Tyr His Gln Glu Gln Ala Val Asn Cys Leu
385                 390                 395                 400 
Leu Gly Asn Val Phe Tyr Glu Arg Leu Ala Gly His Gly Pro Lys Leu
                405                 410                 415     
Gly Pro Val Thr Arg Lys His Pro Leu Val Thr Arg Tyr Phe Thr Phe
            420                 425                 430         
Pro Phe Glu Glu Ile Asp Phe Ser Met Glu Glu Ser Met Ile His Leu
        435                 440                 445             
Pro Asn Lys Ala Cys Phe Leu Met Ala His Asn Gly Trp Val Met Gly
    450                 455                 460                 
Asp Asp Pro Leu Arg Asn Phe Ala Glu Pro Gly Ser Glu Val Tyr Leu
465                 470                 475                 480 
Arg Arg Glu Leu Ile Cys Trp Gly Asp Ser Val Lys Leu Arg Tyr Gly
                485                 490                 495     
Asn Lys Pro Glu Asp Cys Pro Tyr Leu Trp Ala His Met Lys Lys Tyr
            500                 505                 510         
Thr Glu Ile Thr Ala Thr Tyr Phe Gln Gly Val Arg Leu Asp Asn Cys
        515                 520                 525             
His Ser Thr Pro Leu His Val Ala Glu Tyr Met Leu Asp Ala Ala Arg
    530                 535                 540                 
Asn Leu Gln Pro Asn Leu Tyr Val Val Ala Glu Leu Phe Thr Gly Ser
545                 550                 555                 560 
Glu Asp Leu Asp Asn Val Phe Val Thr Arg Leu Gly Ile Ser Ser Leu
                565                 570                 575     
Ile Arg Glu Ala Met Ser Ala Tyr Asn Ser His Glu Glu Gly Arg Leu
            580                 585                 590         
Val Tyr Arg Tyr Gly Gly Glu Pro Val Gly Ser Phe Val Gln Pro Cys
        595                 600                 605             
Leu Arg Pro Leu Met Pro Ala Ile Ala His Ala Leu Phe Met Asp Ile
    610                 615                 620                 
Thr His Asp Asn Glu Cys Pro Ile Val His Arg Ser Ala Tyr Asp Ala
625                 630                 635                 640 
Leu Pro Ser Thr Thr Ile Val Ser Met Ala Cys Cys Ala Ser Gly Ser
                645                 650                 655     
Thr Arg Gly Tyr Asp Glu Leu Val Pro His Gln Ile Ser Val Val Ser
            660                 665                 670         
Glu Glu Arg Phe Tyr Thr Lys Trp Asn Pro Glu Ala Leu Pro Ser Asn
        675                 680                 685             
Thr Gly Glu Val Asn Phe Gln Ser Gly Ile Ile Ala Ala Arg Cys Ala
    690                 695                 700                 
Ile Ser Lys Leu His Gln Glu Leu Gly Ala Lys Val Val Leu Ser Ala
705                 710                 715                 720 
Ser Gln Val Tyr Val Asp Gln Val Asp Glu Asp Ile Val Ala Val Thr
                725                 730                 735     
Arg His Ser Pro Ser Ile His Gln Ser Val Val Ala Val Ser Arg Thr
            740                 745                 750         
Ala Phe Arg Asn Pro Lys Thr Ser Phe Tyr Ser Lys Glu Val Pro Gln
        755                 760                 765             
Met Cys Ile Pro Gly Lys Ile Glu Glu Val Val Leu Glu Ala Arg Thr
    770                 775                 780                 
Ile Glu Arg Asn Thr Lys Pro Tyr Arg Lys Asp Glu Asn Ser Ile Asn
785                 790                 795                 800 
Gly Thr Pro Asp Ile Thr Val Glu Ile Arg Glu His Ile Gln Leu Asn
                805                 810                 815     
Glu Ser Lys Ile Val Lys Gln Ala Gly Val Ala Thr Lys Gly Pro Asn
            820                 825                 830         
Glu Tyr Ile Gln Glu Ile Glu Phe Glu Asn Leu Ser Pro Gly Ser Val
        835                 840                 845             
Ile Ile Phe Arg Val Ser Leu Asp Pro His Ala Gln Val Ala Val Gly
    850                 855                 860                 
Ile Leu Arg Asn His Leu Thr Gln Phe Ser Pro His Phe Lys Ser Gly
865                 870                 875                 880 
Ser Leu Ala Val Asp Asn Ala Asp Pro Ile Leu Lys Ile Pro Phe Ala
                885                 890                 895     
Ser Leu Ala Ser Arg Leu Thr Leu Ala Glu Leu Asn Gln Ile Leu Tyr
            900                 905                 910         
Arg Cys Glu Ser Glu Glu Lys Glu Asp Gly Gly Gly Cys Tyr Asp Ile
        915                 920                 925             
Pro Asn Trp Ser Ala Leu Lys Tyr Ala Gly Leu Gln Gly Leu Met Ser
    930                 935                 940                 
Val Leu Ala Glu Ile Arg Pro Lys Asn Asp Leu Gly His Pro Phe Cys
945                 950                 955                 960 
Asn Asn Leu Arg Ser Gly Asp Trp Met Ile Asp Tyr Val Ser Asn Arg
                965                 970                 975     
Leu Ile Ser Arg Ser Gly Thr Ile Ala Glu Val Gly Lys Trp Leu Gln
            980                 985                 990         
Ala Met Phe Phe Tyr Leu Lys Gln Ile Pro Arg Tyr Leu Ile Pro Cys
        995                 1000                1005            
Tyr Phe Asp Ala Ile Leu Ile Gly Ala Tyr Thr Thr Leu Leu Asp Thr
    1010                1015                1020                
Ala Trp Lys Gln Met Ser Ser Phe Val Gln Asn Gly Ser Thr Phe Val
1025                1030                1035                1040
Lys His Leu Ser Leu Gly Ser Val Gln Leu Cys Gly Val Gly Lys Phe
                1045                1050                1055    
Pro Ser Leu Pro Ile Leu Ser Pro Ala Leu Met Asp Val Pro Tyr Arg
            1060                1065                1070        
Leu Asn Glu Ile Thr Lys Glu Lys Glu Gln Cys Cys Val Ser Leu Ala
        1075                1080                1085            
Ala Gly Leu Pro His Phe Ser Ser Gly Ile Phe Arg Cys Trp Gly Arg
    1090                1095                1100                
Asp Thr Phe Ile Ala Leu Arg Gly Ile Leu Leu Ile Thr Gly Arg Tyr
1105                1110                1115                1120
Val Glu Ala Arg Asn Ile Ile Leu Ala Phe Ala Gly Thr Leu Arg His
                1125                1130                1135    
Gly Leu Ile Pro Asn Leu Leu Gly Glu Gly Ile Tyr Ala Arg Tyr Asn
            1140                1145                1150        
Cys Arg Asp Ala Val Trp Trp Trp Leu Gln Cys Ile Gln Asp Tyr Cys
        1155                1160                1165            
Lys Met Val Pro Asn Gly Leu Asp Ile Leu Lys Cys Pro Val Ser Arg
    1170                1175                1180                
Met Tyr Pro Thr Asp Asp Ser Ala Pro Leu Pro Ala Gly Thr Leu Asp
1185                1190                1195                1200
Gln Pro Leu Phe Glu Val Ile Gln Glu Ala Met Gln Lys His Met Gln
                1205                1210                1215    
Gly Ile Gln Phe Arg Glu Arg Asn Ala Gly Pro Gln Ile Asp Arg Asn
            1220                1225                1230        
Met Lys Asp Glu Gly Phe Asn Ile Thr Ala Gly Val Asp Glu Glu Thr
        1235                1240                1245            
Gly Phe Val Tyr Gly Gly Asn Arg Phe Asn Cys Gly Thr Trp Met Asp
    1250                1255                1260                
Lys Met Gly Glu Ser Asp Arg Ala Arg Asn Arg Gly Ile Pro Ala Thr
1265                1270                1275                1280
Pro Arg Asp Gly Ser Ala Val Glu Ile Val Gly Leu Ser Lys Ser Ala
                1285                1290                1295    
Val Arg Trp Leu Leu Glu Leu Ser Lys Lys Asn Ile Phe Pro Tyr His
            1300                1305                1310        
Glu Val Thr Val Lys Arg His Gly Lys Ala Ile Lys Val Ser Tyr Asp
        1315                1320                1325            
Glu Trp Asn Arg Lys Ile Gln Asp Asn Phe Glu Lys Leu Phe His Val
    1330                1335                1340                
Ser Glu Asp Pro Ser Asp Leu Asn Glu Lys His Pro Asn Leu Val His
1345                1350                1355                1360
Lys Arg Gly Ile Tyr Lys Asp Ser Tyr Gly Ala Ser Ser Pro Trp Cys
                1365                1370                1375    
Asp Tyr Gln Leu Arg Pro Asn Phe Thr Ile Ala Met Val Val Ala Pro
            1380                1385                1390        
Glu Leu Phe Thr Thr Glu Lys Ala Trp Lys Ala Leu Glu Ile Ala Glu
        1395                1400                1405            
Lys Lys Leu Leu Gly Pro Leu Gly Met Lys Thr Leu Asp Pro Asp Asp
    1410                1415                1420                
Met Val Tyr Cys Gly Ile Tyr Asp Asn Ala Leu Asp Asn Asp Asn Tyr
1425                1430                1435                1440
Asn Leu Ala Lys Gly Phe Asn Tyr His Gln Gly Pro Glu Trp Leu Trp
                1445                1450                1455    
Pro Ile Gly Tyr Phe Leu Arg Ala Lys Leu Tyr Phe Ser Arg Leu Met
            1460                1465                1470        
Gly Pro Glu Thr Thr Ala Lys Thr Ile Val Leu Val Lys Asn Val Leu
        1475                1480                1485            
Ser Arg His Tyr Val His Leu Glu Arg Ser Pro Trp Lys Gly Leu Pro
    1490                1495                1500                
Glu Leu Thr Asn Glu Asn Ala Gln Tyr Cys Pro Phe Ser Cys Glu Thr
1505                1510                1515                1520
Gln Ala Trp Ser Ile Ala Thr Ile Leu Glu Thr Leu Tyr Asp Leu
                1525                1530                1535


<210> 8430
<211> 293
<212> PRT
<213> Homo sapiens

<400> 8430
Met Ala Asp Leu Leu Gly Ser Ile Leu Ser Ser Met Glu Lys Pro Pro
 1               5                  10                  15      
Ser Leu Gly Asp Gln Glu Thr Arg Arg Lys Ala Arg Glu Gln Ala Ala
            20                  25                  30          
Arg Leu Lys Lys Leu Gln Glu Gln Glu Lys Gln Gln Lys Val Glu Phe
        35                  40                  45              
Arg Lys Arg Met Glu Lys Glu Val Ser Asp Phe Ile Gln Asp Ser Gly
    50                  55                  60                  
Gln Ile Lys Lys Lys Phe Gln Pro Met Asn Lys Ile Glu Arg Ser Ile
65                  70                  75                  80  
Leu His Asp Val Val Glu Val Ala Gly Leu Thr Ser Phe Ser Phe Gly
                85                  90                  95      
Glu Asp Asp Asp Cys Arg Tyr Val Met Ile Phe Lys Lys Glu Phe Ala
            100                 105                 110         
Pro Ser Asp Glu Glu Leu Asp Ser Tyr Arg Arg Gly Glu Glu Trp Asp
        115                 120                 125             
Pro Gln Lys Ala Glu Glu Lys Arg Lys Leu Lys Glu Leu Ala Gln Arg
    130                 135                 140                 
Gln Glu Glu Glu Ala Ala Gln Gln Gly Pro Val Val Val Ser Pro Ala
145                 150                 155                 160 
Ser Asp Tyr Lys Asp Lys Tyr Ser His Leu Ile Gly Lys Gly Ala Ala
                165                 170                 175     
Lys Asp Ala Ala His Met Leu Gln Ala Asn Lys Thr Tyr Gly Cys Val
            180                 185                 190         
Pro Val Ala Asn Lys Arg Asp Thr Arg Ser Ile Glu Glu Ala Met Asn
        195                 200                 205             
Glu Ile Arg Ala Lys Lys Arg Leu Arg Gln Ser Gly Glu Glu Leu Pro
    210                 215                 220                 
Pro Thr Ser Arg Arg Pro Ala Gln Leu Pro Leu Thr Pro Gly Ala Gly
225                 230                 235                 240 
Gln Gly Ala Gly Arg Asp Lys Ala Ala Ala Ile Arg Ala His Pro Gly
                245                 250                 255     
Ala Pro Pro Leu Asn His Leu Leu Pro Ala Val Pro Gln Ala Gly Gly
            260                 265                 270         
Lys Gln Val Phe Asp Leu Ser Pro Leu Glu Leu Gly Tyr Val Arg Gly
        275                 280                 285             
Met Cys Val Cys Val
    290             


<210> 8431
<211> 515
<212> PRT
<213> Homo sapiens

<400> 8431
Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn
 1               5                  10                  15      
Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys
            20                  25                  30          
Thr Ala Ser Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg
        35                  40                  45              
Arg Asp Ile Ser Asn Thr Leu Ile Met Leu Ala Asp Lys His Ala Lys
    50                  55                  60                  
Glu Ile Glu Glu Glu Ser Glu Thr Thr Val Glu Ala Asp Leu Thr Asp
65                  70                  75                  80  
Lys Gln Lys His Gln Leu Lys His Arg Glu Leu Phe Leu Ser Arg Gln
                85                  90                  95      
Tyr Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val Ala
            100                 105                 110         
Leu Leu Asn Glu Thr Glu Ser Val Leu Ser Tyr Leu Asp Lys Glu Asp
        115                 120                 125             
Thr Phe Phe Tyr Ser Leu Val Tyr Asp Pro Ser Leu Lys Thr Leu Leu
    130                 135                 140                 
Ala Asp Lys Gly Glu Ile Arg Val Gly Pro Arg Tyr Gln Ala Asp Ile
145                 150                 155                 160 
Pro Glu Met Leu Leu Glu Gly Glu Ser Asp Glu Arg Glu Gln Ser Lys
                165                 170                 175     
Leu Glu Val Lys Val Trp Asp Pro Asn Ser Pro Leu Thr Asp Arg Gln
            180                 185                 190         
Ile Asp Gln Phe Leu Val Val Ala Arg Ala Val Gly Thr Phe Ala Arg
        195                 200                 205             
Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met Ser
    210                 215                 220                 
Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp Thr
225                 230                 235                 240 
Leu Tyr Arg His Ser Tyr Asp Leu Ser Ser Ala Ile Ser Val Leu Val
                245                 250                 255     
Pro Leu Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp Ser
            260                 265                 270         
Ala Ser Glu Ala Ser Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly Lys
        275                 280                 285             
Asp Phe Asn Asp Ile Arg Gln Asp Phe Leu Pro Trp Lys Ser Leu Thr
    290                 295                 300                 
Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr Val
305                 310                 315                 320 
Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys Gln
                325                 330                 335     
Val Tyr Ile Pro Thr Tyr Ser Lys Pro Asn Pro Asn Gln Ile Ser Thr
            340                 345                 350         
Ser Asn Gly Lys Pro Gly Ala Val Asn Gly Ala Val Gly Thr Thr Phe
        355                 360                 365             
Gln Pro Gln Asn Pro Leu Leu Gly Arg Ala Cys Glu Ser Cys Tyr Ala
    370                 375                 380                 
Thr Gln Ser His Gln Trp Tyr Ser Trp Gly Pro Pro Asn Met Gln Cys
385                 390                 395                 400 
Arg Leu Cys Ala Ile Cys Trp Leu Tyr Trp Lys Lys Tyr Gly Gly Leu
                405                 410                 415     
Lys Met Pro Thr Gln Ser Glu Glu Glu Lys Leu Ser Pro Ser Pro Thr
            420                 425                 430         
Thr Glu Asp Pro Arg Val Arg Ser His Val Ser Arg Gln Ala Met Gln
        435                 440                 445             
Gly Met Pro Val Arg Asn Thr Gly Ser Pro Lys Ser Ala Val Lys Thr
    450                 455                 460                 
Arg Gln Ala Phe Phe Leu His Thr Thr Tyr Phe Thr Lys Phe Ala Arg
465                 470                 475                 480 
Gln Val Cys Lys Asn Thr Leu Arg Leu Arg Gln Ala Ala Arg Arg Pro
                485                 490                 495     
Phe Val Ala Ile Asn Tyr Ala Ala Ile Arg Ala Glu Cys Lys Met Leu
            500                 505                 510         
Leu Asn Ser
        515 


<210> 8432
<211> 594
<212> PRT
<213> Homo sapiens

<400> 8432
Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn
 1               5                  10                  15      
Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys
            20                  25                  30          
Thr Ala Ser Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg
        35                  40                  45              
Arg Asp Ile Ser Asn Thr Leu Ile Met Leu Ala Asp Lys His Ala Lys
    50                  55                  60                  
Glu Ile Glu Glu Glu Ser Glu Thr Thr Val Glu Ala Asp Leu Thr Asp
65                  70                  75                  80  
Lys Gln Lys His Gln Leu Lys His Arg Glu Leu Phe Leu Ser Arg Gln
                85                  90                  95      
Tyr Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val Ala
            100                 105                 110         
Leu Leu Asn Glu Thr Glu Ser Val Leu Ser Tyr Leu Asp Lys Glu Asp
        115                 120                 125             
Thr Phe Phe Tyr Ser Leu Val Tyr Asp Pro Ser Leu Lys Thr Leu Leu
    130                 135                 140                 
Ala Asp Lys Gly Glu Ile Arg Val Gly Pro Arg Tyr Gln Ala Asp Ile
145                 150                 155                 160 
Pro Glu Met Leu Leu Glu Gly Glu Ser Asp Glu Arg Glu Gln Ser Lys
                165                 170                 175     
Leu Glu Val Lys Val Trp Asp Pro Asn Ser Pro Leu Thr Asp Arg Gln
            180                 185                 190         
Ile Asp Gln Phe Leu Val Val Ala Arg Ala Val Gly Thr Phe Ala Arg
        195                 200                 205             
Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met Ser
    210                 215                 220                 
Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp Thr
225                 230                 235                 240 
Leu Tyr Arg His Ser Tyr Asp Leu Ser Ser Ala Ile Ser Val Leu Val
                245                 250                 255     
Pro Leu Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp Ser
            260                 265                 270         
Ala Ser Glu Ala Ser Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly Lys
        275                 280                 285             
Asp Phe Asn Asp Ile Arg Gln Asp Phe Leu Pro Trp Lys Ser Leu Thr
    290                 295                 300                 
Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr Val
305                 310                 315                 320 
Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys Gln
                325                 330                 335     
Val Tyr Ile Pro Thr Tyr Ser Lys Pro Asn Pro Asn Gln Ile Ser Thr
            340                 345                 350         
Ser Asn Gly Lys Pro Gly Ala Val Asn Gly Ala Val Gly Thr Thr Phe
        355                 360                 365             
Gln Pro Gln Asn Pro Leu Leu Gly Arg Ala Cys Glu Ser Cys Tyr Ala
    370                 375                 380                 
Thr Gln Ser His Gln Trp Tyr Ser Trp Gly Pro Pro Asn Met Gln Cys
385                 390                 395                 400 
Arg Leu Cys Ala Ile Cys Trp Leu Tyr Trp Lys Lys Tyr Gly Gly Leu
                405                 410                 415     
Lys Met Pro Thr Gln Ser Glu Glu Glu Lys Leu Ser Pro Ser Pro Thr
            420                 425                 430         
Thr Glu Asp Pro Arg Val Arg Ser His Val Ser Arg Gln Ala Met Gln
        435                 440                 445             
Gly Met Pro Val Arg Asn Thr Gly Ser Pro Lys Ser Ala Val Lys Thr
    450                 455                 460                 
Arg Gln Ala Phe Phe Leu His Thr Thr Tyr Phe Thr Lys Phe Ala Arg
465                 470                 475                 480 
Gln Val Cys Lys Asn Thr Leu Arg Leu Arg Gln Ala Ala Arg Arg Pro
                485                 490                 495     
Phe Val Ala Ile Asn Tyr Ala Ala Ile Arg Ala Glu Tyr Ala Asp Arg
            500                 505                 510         
His Ala Glu Leu Ser Gly Ser Pro Leu Lys Ser Lys Ser Thr Arg Lys
        515                 520                 525             
Pro Leu Ala Cys Ile Ile Gly Tyr Leu Glu Ile His Pro Ala Lys Lys
    530                 535                 540                 
Pro Asn Val Ile Arg Ser Thr Pro Ser Leu Gln Thr Pro Thr Thr Lys
545                 550                 555                 560 
Arg Met Leu Thr Thr Pro Asn His Thr Ser Leu Ser Ile Leu Gly Lys
                565                 570                 575     
Arg Asn Tyr Ser His His Asn Gly Leu Asp Glu Leu Thr Cys Cys Val
            580                 585                 590         
Ser Asp
        


<210> 8433
<211> 724
<212> PRT
<213> Homo sapiens

<400> 8433
Met Ala Ala Leu Glu Glu Glu Phe Thr Leu Ser Ser Val Val Leu Ser
 1               5                  10                  15      
Ala Gly Pro Glu Gly Leu Leu Gly Val Glu Gln Ser Asp Lys Thr Asp
            20                  25                  30          
Gln Phe Leu Val Thr Asp Ser Gly Arg Thr Val Ile Leu Tyr Lys Val
        35                  40                  45              
Ser Asp Gln Lys Pro Leu Gly Ser Trp Ser Val Lys Gln Gly Gln Ile
    50                  55                  60                  
Ile Thr Cys Pro Ala Val Cys Asn Phe Gln Thr Gly Glu Tyr Val Val
65                  70                  75                  80  
Val His Asp Asn Lys Val Leu Arg Ile Trp Asn Asn Glu Asp Val Asn
                85                  90                  95      
Leu Asp Lys Val Phe Lys Ala Thr Leu Ser Ala Glu Val Tyr Arg Ile
            100                 105                 110         
Leu Ser Val Gln Gly Thr Glu Pro Leu Val Leu Phe Lys Glu Gly Ala
        115                 120                 125             
Val Arg Gly Leu Glu Ala Leu Leu Ala Asp Pro Gln Gln Lys Ile Glu
    130                 135                 140                 
Thr Val Ile Ser Asp Glu Glu Val Ile Lys Trp Thr Lys Phe Phe Val
145                 150                 155                 160 
Val Phe Arg His Pro Val Leu Ile Phe Ile Thr Glu Lys His Gly Asn
                165                 170                 175     
Tyr Phe Ala Tyr Val Gln Met Phe Asn Ser Arg Ile Leu Thr Lys Tyr
            180                 185                 190         
Thr Leu Leu Leu Gly Gln Asp Glu Asn Ser Val Ile Lys Ser Phe Thr
        195                 200                 205             
Ala Ser Val Asp Arg Lys Phe Ile Ser Leu Met Ser Leu Ser Ser Asp
    210                 215                 220                 
Gly Cys Ile Tyr Glu Thr Leu Ile Pro Ile Arg Pro Ala Asp Pro Glu
225                 230                 235                 240 
Lys Asn Gln Ser Leu Val Lys Ser Leu Leu Leu Lys Ala Val Val Ser
                245                 250                 255     
Gly Asn Ala Arg Asn Gly Val Ala Leu Thr Ala Leu Asp Gln Asp His
            260                 265                 270         
Val Ala Val Leu Gly Ser Pro Leu Ala Ala Ser Lys Glu Cys Leu Ser
        275                 280                 285             
Val Trp Asn Ile Lys Phe Gln Thr Leu Gln Thr Ser Lys Glu Leu Pro
    290                 295                 300                 
Gln Gly Thr Ser Gly Gln Leu Trp Tyr Tyr Gly Glu His Leu Phe Met
305                 310                 315                 320 
Leu His Gly Lys Ser Leu Thr Val Ile Pro Tyr Lys Cys Glu Val Ser
                325                 330                 335     
Ser Leu Ala Gly Ala Leu Gly Lys Leu Lys His Ser Gln Asp Pro Gly
            340                 345                 350         
Thr His Val Val Ser His Phe Val Asn Trp Glu Thr Pro Gln Gly Cys
        355                 360                 365             
Gly Leu Gly Phe Gln Asn Ser Glu Gln Ser Arg Arg Ile Leu Arg Arg
    370                 375                 380                 
Arg Lys Ile Glu Val Ser Leu Gln Pro Glu Val Pro Pro Ser Lys Gln
385                 390                 395                 400 
Leu Leu Ser Thr Ile Met Lys Asp Ser Glu Lys His Ile Glu Val Glu
                405                 410                 415     
Val Arg Lys Phe Leu Ala Leu Lys Gln Thr Pro Asp Phe His Thr Val
            420                 425                 430         
Ile Gly Asp Thr Val Thr Gly Leu Leu Glu Arg Cys Lys Ala Glu Pro
        435                 440                 445             
Ser Phe Tyr Pro Arg Asn Cys Leu Met Gln Leu Ile Gln Thr His Val
    450                 455                 460                 
Leu Ser Tyr Arg Phe Phe Cys Leu Ser Leu Cys Pro Asp Leu Met Glu
465                 470                 475                 480 
Ile Ala Leu Lys Lys Lys Asp Val Gln Leu Leu Gln Leu Cys Leu Gln
                485                 490                 495     
Gln Phe Pro Asp Ile Pro Glu Ser Val Thr Cys Ala Cys Leu Lys Ile
            500                 505                 510         
Phe Leu Ser Ile Gly Asp Asp Ser Leu Gln Glu Thr Asp Val Asn Met
        515                 520                 525             
Glu Ser Val Phe Asp Tyr Ser Ile Asn Ser Val His Asp Glu Lys Met
    530                 535                 540                 
Glu Glu Gln Thr Glu Ile Leu Gln Asn Gly Phe Asn Pro Glu Glu Asp
545                 550                 555                 560 
Lys Cys Asn Asn Cys Asp Gln Glu Leu Asn Lys Lys Pro Gln Asp Glu
                565                 570                 575     
Thr Lys Glu Ser Thr Ser Cys Pro Val Val Gln Lys Arg Ala Ala Leu
            580                 585                 590         
Leu Asn Ala Ile Leu His Ser Ala Tyr Ser Glu Thr Phe Leu Leu Pro
        595                 600                 605             
His Leu Lys Asp Ile Pro Ala Gln His Ile Thr Leu Phe Leu Lys Tyr
    610                 615                 620                 
Leu Tyr Phe Leu Tyr Leu Lys Cys Ser Glu Asn Ala Thr Met Thr Leu
625                 630                 635                 640 
Pro Gly Ile His Pro Pro Thr Leu Asn Gln Ile Met Asp Trp Ile Cys
                645                 650                 655     
Leu Leu Leu Asp Ala Asn Phe Thr Val Val Val Met Met Pro Glu Ala
            660                 665                 670         
Lys Arg Leu Leu Ile Asn Leu Tyr Lys Leu Val Lys Ser Gln Ile Ser
        675                 680                 685             
Val Tyr Ser Glu Leu Asn Lys Ile Glu Val Ser Phe Arg Glu Leu Gln
    690                 695                 700                 
Lys Leu Asn Gln Glu Lys Asn Asn Arg Gly Leu Tyr Ser Ile Glu Val
705                 710                 715                 720 
Leu Glu Leu Phe
                


<210> 8434
<211> 1495
<212> PRT
<213> Homo sapiens

<400> 8434
Pro Ser Pro Glu Ala Gly Gly Gly Gly Gly Ala Leu Lys Ala Ser Ser
 1               5                  10                  15      
Ala Arg Ala Ala Ala Ala Gly Leu Leu Arg Glu Ala Gly Ser Gly Gly
            20                  25                  30          
Arg Glu Arg Ala Asp Trp Arg Arg Arg Gln Leu Arg Lys Val Arg Ser
        35                  40                  45              
Val Glu Leu Asp Gln Leu Pro Glu Gln Pro Leu Phe Leu Ala Ala Ser
    50                  55                  60                  
Pro Pro Ala Ser Ser Thr Ser Pro Ser Pro Glu Pro Ala Asp Ala Ala
65                  70                  75                  80  
Gly Ser Gly Thr Gly Phe Gln Pro Val Ala Val Pro Pro Pro His Gly
                85                  90                  95      
Ala Ala Ser Arg Arg Gly Ala His Leu Thr Glu Ser Val Ala Ala Pro
            100                 105                 110         
Asp Ser Gly Ala Ser Ser Pro Ala Ala Ala Glu Pro Gly Glu Lys Arg
        115                 120                 125             
Ala Pro Ala Ala Glu Pro Ser Pro Ala Ala Ala Pro Ala Gly Arg Glu
    130                 135                 140                 
Met Glu Asn Lys Glu Thr Leu Lys Gly Leu His Lys Met Asp Asp Arg
145                 150                 155                 160 
Pro Glu Glu Arg Met Ile Arg Glu Lys Leu Lys Ala Thr Cys Met Pro
                165                 170                 175     
Ala Trp Lys His Glu Trp Leu Glu Arg Arg Asn Arg Arg Gly Pro Val
            180                 185                 190         
Val Val Lys Pro Ile Pro Val Lys Gly Asp Gly Ser Glu Met Asn His
        195                 200                 205             
Leu Ala Ala Glu Ser Pro Gly Glu Val Gln Ala Ser Ala Ala Ser Pro
    210                 215                 220                 
Ala Ser Lys Gly Arg Arg Ser Pro Ser Pro Gly Asn Ser Pro Ser Gly
225                 230                 235                 240 
Arg Thr Val Lys Ser Glu Ser Pro Gly Val Arg Arg Lys Arg Val Ser
                245                 250                 255     
Pro Val Pro Phe Gln Ser Gly Arg Ile Thr Pro Pro Arg Arg Ala Pro
            260                 265                 270         
Ser Pro Asp Gly Phe Ser Pro Tyr Ser Pro Glu Glu Thr Asn Arg Arg
        275                 280                 285             
Val Asn Lys Val Met Arg Ala Arg Leu Tyr Leu Leu Gln Gln Ile Gly
    290                 295                 300                 
Pro Asn Ser Phe Leu Ile Gly Gly Asp Ser Pro Asp Asn Lys Tyr Arg
305                 310                 315                 320 
Val Phe Ile Gly Pro Gln Asn Cys Ser Cys Ala His Gly Thr Phe Cys
                325                 330                 335     
Ile His Leu Leu Phe Val Met Leu Arg Val Phe Gln Leu Glu Pro Ser
            340                 345                 350         
Asp Pro Met Leu Trp Arg Lys Thr Leu Lys Asn Phe Glu Val Glu Ser
        355                 360                 365             
Leu Phe Gln Lys Tyr His Ser Arg Arg Ser Ser Arg Ile Lys Ala Pro
    370                 375                 380                 
Ser Arg Asn Thr Ile Gln Lys Phe Val Ser Arg Met Ser Asn Ser His
385                 390                 395                 400 
Thr Leu Ser Ser Ser Ser Thr Ser Thr Ser Ser Ser Glu Asn Ser Ile
                405                 410                 415     
Lys Asp Glu Glu Glu Gln Met Cys Pro Ile Cys Leu Leu Gly Met Leu
            420                 425                 430         
Asp Glu Glu Ser Leu Thr Val Cys Glu Asp Gly Cys Arg Asn Lys Leu
        435                 440                 445             
His His His Cys Met Ser Ile Trp Ala Glu Glu Cys Arg Arg Asn Arg
    450                 455                 460                 
Glu Pro Leu Ile Cys Pro Leu Cys Arg Ser Lys Trp Arg Ser His Asp
465                 470                 475                 480 
Phe Tyr Ser His Glu Leu Ser Ser Pro Val Asp Ser Pro Ser Ser Leu
                485                 490                 495     
Arg Ala Ala Gln Gln Gln Thr Val Gln Gln Gln Pro Leu Ala Gly Ser
            500                 505                 510         
Arg Arg Asn Gln Glu Ser Asn Phe Asn Leu Thr His Tyr Gly Thr Gln
        515                 520                 525             
Gln Ile Pro Pro Ala Tyr Lys Asp Leu Ala Glu Pro Trp Ile Gln Val
    530                 535                 540                 
Phe Gly Met Glu Leu Val Gly Cys Leu Phe Ser Arg Asn Trp Asn Val
545                 550                 555                 560 
Arg Glu Met Ala Leu Arg Arg Leu Ser His Asp Val Ser Gly Ala Leu
                565                 570                 575     
Leu Leu Ala Asn Gly Glu Ser Thr Gly Asn Ser Gly Gly Ser Ser Gly
            580                 585                 590         
Ser Ser Pro Ser Gly Gly Ala Thr Ser Gly Ser Ser Gln Thr Ser Ile
        595                 600                 605             
Ser Gly Asp Val Val Glu Ala Cys Cys Ser Val Leu Ser Met Val Cys
    610                 615                 620                 
Ala Asp Pro Val Tyr Lys Val Tyr Val Ala Ala Leu Lys Thr Leu Arg
625                 630                 635                 640 
Ala Met Leu Val Tyr Thr Pro Cys His Ser Leu Ala Glu Arg Ile Lys
                645                 650                 655     
Leu Gln Arg Leu Leu Gln Pro Val Val Asp Thr Ile Leu Val Lys Cys
            660                 665                 670         
Ala Asp Ala Asn Ser Arg Thr Ser Gln Leu Ser Ile Ser Thr Leu Leu
        675                 680                 685             
Glu Leu Cys Lys Gly Gln Ala Gly Glu Leu Ala Val Gly Arg Glu Ile
    690                 695                 700                 
Leu Lys Ala Gly Ser Ile Gly Ile Gly Gly Val Asp Tyr Val Leu Asn
705                 710                 715                 720 
Cys Ile Leu Gly Asn Gln Thr Glu Ser Asn Asn Trp Gln Glu Leu Leu
                725                 730                 735     
Gly Arg Leu Cys Leu Ile Asp Arg Leu Leu Leu Glu Phe Pro Ala Glu
            740                 745                 750         
Phe Tyr Pro His Ile Val Ser Thr Asp Val Ser Gln Ala Glu Pro Val
        755                 760                 765             
Glu Ile Arg Tyr Lys Lys Leu Leu Ser Leu Leu Thr Phe Ala Leu Gln
    770                 775                 780                 
Ser Ile Asp Asn Ser His Ser Met Val Gly Lys Leu Ser Arg Arg Ile
785                 790                 795                 800 
Tyr Leu Ser Ser Ala Arg Met Val Thr Thr Val Pro His Val Phe Ser
                805                 810                 815     
Lys Leu Leu Glu Met Leu Ser Val Ser Ser Val Ser Thr His Phe Thr
            820                 825                 830         
Arg Met Arg Arg Arg Leu Met Ala Tyr Ala Asp Glu Val Glu Ile Ala
        835                 840                 845             
Glu Ala Ile Gln Leu Gly Val Glu Asp Thr Leu Gln Arg Gln Gln His
    850                 855                 860                 
Asn Ser Phe Cys Arg His Leu Phe Pro Thr Thr Ile Trp Lys Pro Gln
865                 870                 875                 880 
Arg Thr Val Pro Leu Glu Cys Thr Val His Leu Glu Lys Thr Gly Lys
                885                 890                 895     
Gly Leu Cys Ala Thr Lys Leu Ser Ala Ser Ser Glu Asp Ile Ser Glu
            900                 905                 910         
Arg Leu Ala Arg Ile Ser Val Gly Pro Ser Ser Ser Thr Thr Thr Thr
        915                 920                 925             
Thr Thr Thr Thr Glu Gln Pro Lys Pro Met Val Gln Thr Lys Gly Arg
    930                 935                 940                 
Pro His Ser Gln Cys Leu Asn Ser Ser Pro Leu Ser His His Ser Gln
945                 950                 955                 960 
Leu Met Phe Pro Ala Leu Ser Thr Pro Ser Ser Ser Thr Pro Ser Val
                965                 970                 975     
Pro Ala Gly Thr Ala Thr Asp Val Ser Lys His Arg Leu Gln Gly Phe
            980                 985                 990         
Ile Pro Cys Arg Ile Pro Ser Ala Ser Pro Gln Thr Gln Arg Lys Phe
        995                 1000                1005            
Ser Leu Gln Phe His Arg Asn Cys Pro Glu Asn Lys Asp Ser Asp Lys
    1010                1015                1020                
Leu Ser Pro Val Phe Thr Gln Ser Arg Pro Leu Pro Ser Ser Asn Ile
1025                1030                1035                1040
His Arg Pro Lys Pro Ser Arg Pro Thr Pro Gly Asn Thr Ser Lys Gln
                1045                1050                1055    
Gly Asp Pro Ser Lys Asn Ser Met Thr Leu Asp Leu Asn Ser Ser Ser
            1060                1065                1070        
Lys Cys Asp Asp Ser Phe Gly Leu Ser Ser Asn Ser Ser Asn Cys Cys
        1075                1080                1085            
Tyr Thr Ser Asp Glu Thr Val Phe Thr Pro Val Glu Glu Lys Cys Arg
    1090                1095                1100                
Leu Asp Val Asn Thr Glu Leu Asn Ser Ser Ile Glu Asp Leu Leu Glu
1105                1110                1115                1120
Ala Ser Met Pro Ser Ser Asp Thr Thr Val Thr Phe Lys Ser Glu Val
                1125                1130                1135    
Ala Val Leu Ser Pro Glu Lys Ala Glu Asn Asp Asp Thr Tyr Lys Asp
            1140                1145                1150        
Asp Val Asn His Asn Gln Lys Cys Lys Glu Lys Met Glu Ala Glu Glu
        1155                1160                1165            
Glu Glu Ala Leu Ala Ile Ala Met Ala Met Ser Ala Ser Gln Val Ala
    1170                1175                1180                
Leu Pro Ile Val Pro Gln Leu Gln Val Glu Asn Gly Glu Asp Ile Ile
1185                1190                1195                1200
Ile Ile Gln Gln Asp Thr Pro Glu Thr Leu Pro Gly His Thr Lys Ala
                1205                1210                1215    
Lys Gln Pro Tyr Arg Glu Asp Thr Glu Trp Leu Lys Gly Gln Gln Ile
            1220                1225                1230        
Gly Leu Gly Ala Phe Ser Ser Cys Tyr Gln Ala Gln Asp Val Gly Thr
        1235                1240                1245            
Gly Thr Leu Met Ala Val Lys Gln Val Thr Tyr Val Arg Asn Thr Ser
    1250                1255                1260                
Ser Glu Gln Glu Glu Val Val Glu Ala Leu Arg Glu Glu Ile Arg Met
1265                1270                1275                1280
Met Ser His Leu Asn His Pro Asn Ile Ile Arg Met Leu Gly Ala Thr
                1285                1290                1295    
Cys Glu Lys Ser Asn Tyr Asn Leu Phe Ile Glu Trp Met Ala Gly Gly
            1300                1305                1310        
Ser Val Ala His Leu Leu Ser Lys Tyr Gly Ala Phe Lys Glu Ser Val
        1315                1320                1325            
Val Ile Asn Tyr Thr Glu Gln Leu Leu Arg Gly Leu Ser Tyr Leu His
    1330                1335                1340                
Glu Asn Gln Ile Ile His Arg Asp Val Lys Gly Ala Asn Leu Leu Ile
1345                1350                1355                1360
Asp Ser Thr Gly Gln Arg Leu Arg Ile Ala Asp Phe Gly Ala Ala Ala
                1365                1370                1375    
Arg Leu Ala Ser Lys Gly Thr Gly Ala Gly Glu Phe Gln Gly Gln Leu
            1380                1385                1390        
Leu Gly Thr Ile Ala Phe Met Ala Pro Glu Val Leu Arg Gly Gln Gln
        1395                1400                1405            
Tyr Gly Arg Ser Cys Asp Val Trp Ser Val Gly Cys Ala Ile Ile Glu
    1410                1415                1420                
Met Ala Cys Ala Lys Pro Pro Trp Asn Ala Glu Lys His Ser Asn His
1425                1430                1435                1440
Leu Ala Leu Ile Phe Lys Ile Ala Ser Ala Thr Thr Ala Pro Ser Ile
                1445                1450                1455    
Pro Ser His Leu Ser Pro Gly Leu Arg Asp Val Ala Leu Arg Cys Leu
            1460                1465                1470        
Glu Leu Gln Pro Gln Asp Arg Pro Pro Ser Arg Glu Leu Leu Lys His
        1475                1480                1485            
Pro Val Phe Arg Thr Thr Trp
    1490                1495


<210> 8435
<211> 424
<212> PRT
<213> Homo sapiens

<400> 8435
Met Ala Ser Met Pro Pro Thr Pro Glu Ala Gln Gly Pro Ile Leu Phe
 1               5                  10                  15      
Glu Asp Leu Ala Val Tyr Phe Ser Gln Glu Glu Cys Val Thr Leu His
            20                  25                  30          
Pro Ala Gln Arg Ser Leu Ser Lys Asp Gly Thr Lys Glu Ser Leu Glu
        35                  40                  45              
Asp Ala Ala Leu Met Gly Glu Glu Gly Lys Pro Glu Ile Asn Gln Gln
    50                  55                  60                  
Leu Ser Leu Glu Ser Met Glu Leu Asp Glu Leu Ala Leu Glu Lys Tyr
65                  70                  75                  80  
Pro Ile Ala Ala Pro Leu Val Pro Tyr Pro Glu Lys Ser Ser Glu Asp
                85                  90                  95      
Gly Val Gly Asn Pro Glu Ala Lys Ile Leu Ser Gly Thr Pro Thr Tyr
            100                 105                 110         
Lys Arg Arg Val Ile Ser Leu Leu Val Thr Ile Glu Asn His Thr Pro
        115                 120                 125             
Leu Val Glu Leu Ser Glu Tyr Leu Gly Thr Asn Thr Leu Ser Glu Ile
    130                 135                 140                 
Leu Asp Ser Pro Trp Glu Gly Ala Lys Asn Val Tyr Lys Cys Pro Glu
145                 150                 155                 160 
Cys Asp Gln Asn Phe Ser Asp His Ser Tyr Leu Val Leu His Gln Lys
                165                 170                 175     
Ile His Ser Gly Glu Lys Lys His Lys Cys Gly Asp Cys Gly Lys Ile
            180                 185                 190         
Phe Asn His Arg Ala Asn Leu Arg Thr His Arg Arg Ile His Thr Gly
        195                 200                 205             
Glu Lys Pro Tyr Lys Cys Ala Lys Cys Ser Ala Ser Phe Arg Gln His
    210                 215                 220                 
Ser His Leu Ser Arg His Met Asn Ser His Val Lys Glu Lys Pro Tyr
225                 230                 235                 240 
Thr Cys Ser Ile Cys Gly Arg Gly Phe Met Trp Leu Pro Gly Leu Ala
                245                 250                 255     
Gln His Gln Lys Ser His Ser Ala Glu Asn Thr Tyr Glu Ser Thr Asn
            260                 265                 270         
Cys Asp Lys His Phe Asn Glu Lys Pro Asn Leu Ala Leu Pro Glu Glu
        275                 280                 285             
Thr Phe Val Ser Gly Pro Gln Tyr Gln His Thr Lys Cys Met Lys Ser
    290                 295                 300                 
Phe Arg Gln Ser Leu Tyr Pro Ala Leu Ser Glu Lys Ser His Asp Glu
305                 310                 315                 320 
Asp Ser Glu Arg Cys Ser Asp Asp Gly Asp Asn Phe Phe Ser Phe Ser
                325                 330                 335     
Lys Phe Lys Pro Leu Gln Cys Pro Asp Cys Asp Met Thr Phe Pro Cys
            340                 345                 350         
Phe Ser Glu Leu Ile Ser His Gln Asn Ile His Thr Glu Glu Arg Pro
        355                 360                 365             
His Lys Cys Lys Thr Cys Glu Glu Ser Phe Ala Leu Asp Ser Glu Leu
    370                 375                 380                 
Ala Cys His Gln Lys Ser His Met Leu Ala Glu Pro Phe Lys Cys Thr
385                 390                 395                 400 
Val Cys Gly Lys Thr Phe Lys Ser Asn Leu His Leu Ile Thr His Lys
                405                 410                 415     
Arg Thr His Ile Lys Asn Thr Thr
            420                 


<210> 8436
<211> 261
<212> PRT
<213> Homo sapiens

<400> 8436
Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly
 1               5                  10                  15      
Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro
            20                  25                  30          
Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu
        35                  40                  45              
Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn
    50                  55                  60                  
Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr
65                  70                  75                  80  
Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp
                85                  90                  95      
Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro
            100                 105                 110         
Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met
        115                 120                 125             
Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn
    130                 135                 140                 
Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His
145                 150                 155                 160 
Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met
                165                 170                 175     
Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp
            180                 185                 190         
Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro
        195                 200                 205             
Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp
    210                 215                 220                 
Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys
225                 230                 235                 240 
Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile
                245                 250                 255     
Ser Leu Asp Gln Gln
            260     


<210> 8437
<211> 79
<212> PRT
<213> Homo sapiens

<400> 8437
Met His Pro Asp Leu Ser Pro His Leu His Thr Glu Glu Cys Asn Val
 1               5                  10                  15      
Leu Ile Asn Leu Leu Lys Glu Cys His Lys Asn His Asn Ile Leu Lys
            20                  25                  30          
Phe Phe Gly Tyr Cys Asn Asp Val Asp Arg Glu Leu Arg Lys Cys Leu
        35                  40                  45              
Lys Asn Glu Tyr Val Glu Asn Arg Thr Lys Ser Arg Glu His Gly Ile
    50                  55                  60                  
Ala Met Arg Lys Lys Leu Phe Asn Pro Pro Glu Glu Ser Glu Lys
65                  70                  75                  


<210> 8438
<211> 919
<212> PRT
<213> Homo sapiens

<400> 8438
Met Glu Ala Pro Glu Tyr Leu Asp Leu Asp Glu Ile Asp Phe Ser Asp
 1               5                  10                  15      
Asp Ile Ser Tyr Ser Val Thr Ser Leu Lys Thr Ile Pro Glu Leu Cys
            20                  25                  30          
Arg Arg Cys Asp Thr Gln Asn Glu Asp Arg Ser Ala Ser Ser Ser Ser
        35                  40                  45              
Trp Asn Cys Gly Ile Ser Thr Leu Ile Thr Asn Thr Gln Lys Pro Thr
    50                  55                  60                  
Gly Ile Ala Asp Val Tyr Ser Lys Phe Arg Pro Val Lys Arg Val Ser
65                  70                  75                  80  
Pro Leu Lys His Gln Pro Glu Thr Leu Glu Asn Asn Glu Ser Asp Asp
                85                  90                  95      
Gln Lys Asn Gln Lys Val Val Glu Tyr Gln Lys Gly Gly Glu Ser Asp
            100                 105                 110         
Leu Gly Pro Gln Pro Gln Glu Leu Gly Pro Gly Asp Gly Val Gly Gly
        115                 120                 125             
Pro Pro Gly Lys Ser Ser Glu Pro Ser Thr Ser Leu Gly Glu Leu Glu
    130                 135                 140                 
His Tyr Asp Leu Asp Met Asp Glu Ile Leu Asp Val Pro Tyr Ile Lys
145                 150                 155                 160 
Ser Ser Gln Gln Leu Ala Ser Phe Thr Lys Val Thr Ser Glu Lys Arg
                165                 170                 175     
Ile Leu Gly Leu Cys Thr Thr Ile Asn Gly Leu Ser Gly Lys Ala Cys
            180                 185                 190         
Ser Thr Gly Ser Ser Glu Ser Ser Ser Ser Asn Met Ala Pro Phe Cys
        195                 200                 205             
Val Leu Ser Pro Val Lys Ser Pro His Leu Arg Lys Ala Ser Ala Val
    210                 215                 220                 
Ile His Asp Gln His Lys Leu Ser Thr Glu Glu Thr Glu Ile Ser Pro
225                 230                 235                 240 
Pro Leu Val Lys Cys Gly Ser Ala Tyr Glu Pro Glu Asn Gln Ser Lys
                245                 250                 255     
Asp Phe Leu Asn Lys Thr Phe Ser Asp Pro His Gly Arg Lys Val Glu
            260                 265                 270         
Lys Thr Thr Pro Asp Cys Gln Leu Arg Ala Phe His Leu Gln Ser Ser
        275                 280                 285             
Ala Ala Glu Ser Lys Pro Glu Glu Gln Val Ser Gly Leu Asn Arg Thr
    290                 295                 300                 
Ser Ser Gln Gly Pro Glu Glu Arg Ser Glu Tyr Leu Lys Lys Val Lys
305                 310                 315                 320 
Ser Ile Leu Asn Ile Val Lys Glu Gly Gln Ile Ser Leu Leu Pro His
                325                 330                 335     
Leu Ala Ala Asp Asn Leu Asp Lys Ile His Asp Glu Asn Gly Asn Asn
            340                 345                 350         
Leu Leu His Ile Ala Ala Ser Gln Gly His Ala Glu Cys Leu Gln His
        355                 360                 365             
Leu Thr Ser Leu Met Gly Glu Asp Cys Leu Asn Glu Arg Asn Thr Glu
    370                 375                 380                 
Lys Leu Thr Pro Ala Gly Leu Ala Ile Lys Asn Gly Gln Leu Glu Cys
385                 390                 395                 400 
Val Arg Trp Met Val Ser Glu Thr Glu Ala Ile Ala Glu Leu Ser Cys
                405                 410                 415     
Ser Lys Asp Phe Pro Ser Leu Ile His Tyr Ala Gly Cys Tyr Gly Gln
            420                 425                 430         
Glu Lys Ile Leu Leu Trp Leu Leu Gln Phe Met Gln Glu Gln Gly Ile
        435                 440                 445             
Ser Leu Asp Glu Val Asp Gln Asp Gly Asn Ser Ala Val His Val Ala
    450                 455                 460                 
Ser Gln His Gly Tyr Leu Gly Cys Ile Gln Thr Leu Val Glu Tyr Gly
465                 470                 475                 480 
Ala Asn Val Thr Met Gln Asn His Ala Gly Glu Lys Pro Ser Gln Ser
                485                 490                 495     
Ala Glu Arg Gln Gly His Thr Leu Cys Ser Arg Tyr Leu Val Val Val
            500                 505                 510         
Glu Thr Cys Met Ser Leu Ala Ser Gln Val Val Lys Leu Thr Lys Gln
        515                 520                 525             
Leu Lys Glu Gln Thr Val Glu Arg Val Thr Leu Gln Asn Gln Leu Gln
    530                 535                 540                 
Gln Phe Leu Glu Ala Gln Lys Ser Glu Gly Lys Ser Leu Pro Ser Ser
545                 550                 555                 560 
Pro Ser Ser Pro Ser Ser Pro Ala Ser Arg Lys Ser Gln Trp Lys Ser
                565                 570                 575     
Pro Asp Ala Asp Asp Asp Ser Val Ala Lys Ser Lys Pro Gly Val Gln
            580                 585                 590         
Glu Gly Ile Gln Val Leu Gly Ser Leu Ser Ala Ser Ser Arg Ala Arg
        595                 600                 605             
Pro Lys Ala Lys Asp Glu Asp Ser Asp Lys Ile Leu Arg Gln Leu Leu
    610                 615                 620                 
Gly Lys Glu Ile Ser Glu Asn Val Cys Thr Gln Glu Lys Leu Ser Leu
625                 630                 635                 640 
Glu Phe Gln Asp Ala Gln Ala Ser Ser Arg Asn Ser Lys Lys Ile Pro
                645                 650                 655     
Leu Glu Lys Arg Glu Leu Lys Leu Ala Arg Leu Arg Gln Leu Met Gln
            660                 665                 670         
Arg Ser Leu Ser Glu Ser Asp Thr Asp Ser Asn Asn Ser Glu Asp Pro
        675                 680                 685             
Lys Thr Thr Pro Val Arg Lys Ala Asp Arg Pro Arg Pro Gln Pro Ile
    690                 695                 700                 
Val Glu Ser Val Glu Ser Met Asp Ser Ala Glu Ser Leu His Leu Met
705                 710                 715                 720 
Ile Lys Lys His Thr Leu Ala Ser Gly Gly Arg Arg Phe Pro Phe Ser
                725                 730                 735     
Ile Lys Ala Ser Lys Ser Leu Asp Gly His Ser Pro Ser Pro Thr Ser
            740                 745                 750         
Glu Ser Ser Glu Pro Asp Leu Glu Ser Gln Tyr Pro Gly Ser Gly Ser
        755                 760                 765             
Ile Pro Pro Asn Gln Pro Ser Gly Asp Pro Gln Gln Pro Ser Pro Asp
    770                 775                 780                 
Ser Thr Ala Ala Gln Lys Val Ala Thr Ser Pro Lys Ser Ala Leu Lys
785                 790                 795                 800 
Ser Pro Ser Ser Lys Arg Arg Thr Ser Gln Asn Leu Lys Leu Arg Val
                805                 810                 815     
Thr Phe Glu Glu Pro Val Val Gln Met Glu Gln Pro Ser Leu Glu Leu
            820                 825                 830         
Asn Gly Glu Lys Asp Lys Asp Lys Gly Arg Thr Leu Gln Arg Thr Ser
        835                 840                 845             
Thr Ser Asn Glu Ser Gly Asp Gln Leu Lys Arg Pro Phe Gly Ala Phe
    850                 855                 860                 
Arg Ser Ile Met Glu Thr Leu Ser Gly Asn Gln Asn Asn Asn Asn Asn
865                 870                 875                 880 
Tyr Gln Ala Ala Asn Gln Leu Lys Thr Ser Thr Leu Pro Leu Thr Ser
                885                 890                 895     
Leu Gly Arg Lys Thr Asp Ala Lys Gly Asn Pro Ala Ser Ser Ala Ser
            900                 905                 910         
Lys Gly Lys Asn Lys Ala Ala
        915                 


<210> 8439
<211> 1016
<212> PRT
<213> Homo sapiens

<400> 8439
Met Glu Ala Pro Glu Tyr Leu Asp Leu Asp Glu Ile Asp Phe Ser Asp
 1               5                  10                  15      
Asp Ile Ser Asp Asn Arg Ser Gln Gly Asn Arg Leu Gln Lys Leu Gly
            20                  25                  30          
Leu Glu Asp Thr Asp Arg Glu Asp Ala Met Gly Phe Gly Ser His Arg
        35                  40                  45              
Ala Lys Leu Thr Val Val Ala Ala Leu Gly Ala Cys His Cys Pro Glu
    50                  55                  60                  
Asn Glu Tyr Ser Val Thr Ser Leu Lys Thr Ile Pro Glu Leu Cys Arg
65                  70                  75                  80  
Arg Cys Asp Thr Gln Asn Glu Asp Arg Ser Val Ser Ser Ser Ser Trp
                85                  90                  95      
Asn Cys Gly Ile Ser Thr Leu Ile Thr Asn Thr Gln Lys Pro Thr Gly
            100                 105                 110         
Ile Ala Asp Val Tyr Ser Lys Phe Arg Pro Val Lys Arg Val Ser Pro
        115                 120                 125             
Leu Lys His Gln Pro Glu Thr Leu Glu Asn Asn Glu Ser Asp Asp Gln
    130                 135                 140                 
Lys Asn Gln Lys Val Val Glu Tyr Gln Lys Gly Gly Glu Ser Asp Leu
145                 150                 155                 160 
Gly Pro Gln Pro Gln Glu Leu Gly Pro Gly Asp Gly Val Gly Gly Pro
                165                 170                 175     
Pro Gly Lys Ser Ser Glu Pro Ser Thr Ser Leu Gly Glu Leu Glu His
            180                 185                 190         
Tyr Asp Leu Asp Met Asp Glu Ile Leu Asp Val Pro Tyr Ile Lys Ser
        195                 200                 205             
Ser Gln Gln Leu Ala Ser Phe Thr Lys Val Thr Ser Glu Lys Arg Ile
    210                 215                 220                 
Leu Gly Leu Cys Thr Thr Ile Asn Gly Leu Ser Gly Lys Ala Cys Ser
225                 230                 235                 240 
Thr Gly Ser Ser Glu Ser Ser Ser Ser Asn Met Ala Pro Phe Cys Val
                245                 250                 255     
Leu Ser Pro Val Lys Ser Pro His Leu Arg Lys Ala Ser Ala Val Ile
            260                 265                 270         
His Asp Gln His Lys Leu Ser Thr Glu Glu Thr Glu Ile Ser Pro Pro
        275                 280                 285             
Leu Val Lys Cys Gly Ser Ala Tyr Glu Pro Glu Asn Gln Ser Lys Asp
    290                 295                 300                 
Phe Leu Asn Lys Thr Phe Ser Asp Pro His Gly Arg Lys Val Glu Lys
305                 310                 315                 320 
Thr Thr Pro Asp Cys Gln Leu Arg Ala Phe His Leu Gln Ser Ser Ala
                325                 330                 335     
Ala Glu Ser Lys Pro Glu Glu Gln Val Ser Gly Leu Asn Arg Thr Ser
            340                 345                 350         
Ser Gln Gly Pro Glu Glu Arg Ser Glu Tyr Leu Lys Lys Val Lys Ser
        355                 360                 365             
Ile Leu Asn Ile Val Lys Glu Gly Gln Ile Ser Leu Leu Pro His Leu
    370                 375                 380                 
Ala Ala Asp Asn Leu Asp Lys Ile His Asp Glu Asn Gly Asn Asn Leu
385                 390                 395                 400 
Leu His Ile Ala Ala Ser Gln Gly His Ala Glu Cys Leu Gln His Leu
                405                 410                 415     
Thr Ser Leu Met Gly Glu Asp Cys Leu Asn Glu Arg Asn Thr Glu Lys
            420                 425                 430         
Leu Thr Pro Ala Gly Leu Ala Ile Lys Asn Gly Gln Leu Glu Cys Val
        435                 440                 445             
Arg Trp Met Val Ser Glu Thr Glu Ala Ile Ala Glu Leu Ser Cys Ser
    450                 455                 460                 
Lys Asp Phe Pro Ser Leu Ile His Tyr Ala Gly Cys Tyr Gly Gln Glu
465                 470                 475                 480 
Lys Ile Leu Leu Trp Leu Leu Gln Phe Met Gln Glu Gln Gly Ile Ser
                485                 490                 495     
Leu Asp Glu Val Asp Gln Asp Gly Asn Ser Ala Val His Val Ala Ser
            500                 505                 510         
Gln His Gly Tyr Leu Gly Cys Ile Gln Thr Leu Val Glu Tyr Gly Ala
        515                 520                 525             
Asn Val Thr Met Gln Asn His Ala Gly Glu Lys Pro Ser Gln Ser Ala
    530                 535                 540                 
Glu Arg Gln Gly His Thr Leu Cys Ser Arg Tyr Leu Val Val Val Glu
545                 550                 555                 560 
Thr Cys Met Ser Leu Ala Ser Gln Val Val Lys Leu Thr Lys Gln Leu
                565                 570                 575     
Lys Glu Gln Thr Val Glu Arg Val Thr Leu Gln Asn Gln Leu Gln Gln
            580                 585                 590         
Phe Leu Glu Ala Gln Lys Ser Glu Gly Lys Ser Leu Pro Ser Ser Pro
        595                 600                 605             
Ser Ser Pro Ser Ser Pro Ala Ser Arg Lys Ser Gln Trp Lys Ser Pro
    610                 615                 620                 
Asp Ala Asp Asp Asp Ser Val Ala Lys Ser Lys Pro Gly Val Gln Glu
625                 630                 635                 640 
Gly Ile Gln Val Leu Gly Ser Leu Ser Ala Ser Ser Arg Ala Arg Pro
                645                 650                 655     
Lys Ala Lys Asp Glu Asp Ser Asp Lys Ile Leu Arg Gln Leu Leu Gly
            660                 665                 670         
Lys Glu Ile Ser Glu Asn Val Cys Thr Gln Glu Lys Leu Ser Leu Glu
        675                 680                 685             
Phe Gln Asp Ala Gln Ala Ser Ser Arg Asn Ser Lys Lys Ile Pro Leu
    690                 695                 700                 
Glu Lys Arg Glu Leu Lys Leu Ala Arg Leu Arg Gln Leu Met Gln Arg
705                 710                 715                 720 
Ser Leu Ser Glu Ser Asp Thr Asp Ser Asn Asn Ser Glu Asp Pro Lys
                725                 730                 735     
Thr Thr Pro Val Arg Lys Ala Asp Arg Pro Arg Pro Gln Pro Ile Val
            740                 745                 750         
Glu Ser Val Glu Ser Met Asp Ser Ala Glu Ser Leu His Leu Met Ile
        755                 760                 765             
Lys Lys His Thr Leu Ala Ser Gly Gly Arg Arg Phe Pro Phe Ser Ile
    770                 775                 780                 
Lys Ala Ser Lys Ser Leu Asp Gly His Ser Pro Ser Pro Thr Ser Glu
785                 790                 795                 800 
Ser Ser Glu Pro Asp Leu Glu Ser Gln Tyr Pro Gly Ser Gly Ser Ile
                805                 810                 815     
Pro Pro Asn Gln Pro Ser Gly Asp Pro Gln Gln Pro Ser Pro Asp Ser
            820                 825                 830         
Thr Ala Ala Gln Lys Val Ala Thr Ser Pro Lys Ser Ala Leu Lys Ser
        835                 840                 845             
Pro Ser Ser Lys Arg Arg Thr Ser Gln Asn Leu Lys Leu Arg Val Thr
    850                 855                 860                 
Phe Glu Glu Pro Val Val Gln Met Glu Gln Pro Ser Leu Glu Leu Asn
865                 870                 875                 880 
Gly Glu Lys Asp Lys Asp Lys Gly Arg Thr Leu Gln Arg Thr Ser Thr
                885                 890                 895     
Ser Asn Glu Ser Gly Asp Gln Leu Lys Arg Pro Phe Gly Ala Phe Arg
            900                 905                 910         
Ser Ile Met Glu Thr Leu Ser Gly Asn Gln Asn Asn Asn Asn Asn Tyr
        915                 920                 925             
Gln Ala Ala Asn Gln Leu Lys Thr Ser Thr Leu Pro Leu Thr Ser Leu
    930                 935                 940                 
Gly Arg Lys Thr Asp Ala Lys Gly Asn Pro Ala Ser Ser Ala Ser Lys
945                 950                 955                 960 
Gly Lys Asn Lys Ala Glu Met Tyr Ser Ser Cys Ile Asn Leu Ser Ser
                965                 970                 975     
Asn Met Leu Ile Glu Glu His Leu Cys Asn Asp Thr Arg His Asn Asp
            980                 985                 990         
Ile Asn Arg Lys Met Lys Lys Ser Tyr Ser Ile Lys His Ile Ala Glu
        995                 1000                1005            
Pro Glu Ser Lys Glu Leu Phe Leu
    1010                1015    


<210> 8440
<211> 717
<212> PRT
<213> Homo sapiens

<400> 8440
Met Ser Val Asp Glu Lys Pro Asp Ser Pro Met Tyr Val Tyr Glu Ser
 1               5                  10                  15      
Thr Val His Cys Thr Asn Ile Leu Leu Gly Leu Asn Asp Gln Arg Lys
            20                  25                  30          
Lys Asp Ile Leu Cys Asp Val Thr Leu Ile Val Glu Arg Lys Glu Phe
        35                  40                  45              
Arg Ala His Arg Ala Val Leu Ala Ala Cys Ser Glu Tyr Phe Trp Gln
    50                  55                  60                  
Ala Leu Val Gly Gln Thr Lys Asn Asp Leu Val Val Ser Leu Pro Glu
65                  70                  75                  80  
Glu Val Thr Ala Arg Gly Phe Gly Pro Leu Leu Gln Phe Ala Tyr Thr
                85                  90                  95      
Ala Lys Leu Leu Leu Ser Arg Glu Asn Ile Arg Glu Val Ile Arg Cys
            100                 105                 110         
Ala Glu Phe Leu Arg Met His Asn Leu Glu Asp Ser Cys Phe Ser Phe
        115                 120                 125             
Leu Gln Thr Gln Leu Leu Asn Ser Glu Asp Gly Leu Phe Val Cys Arg
    130                 135                 140                 
Lys Asp Ala Ala Cys Gln Arg Pro His Glu Asp Cys Glu Asn Ser Ala
145                 150                 155                 160 
Gly Glu Glu Glu Asp Glu Glu Glu Glu Thr Met Asp Ser Glu Thr Ala
                165                 170                 175     
Lys Met Ala Cys Pro Arg Asp Gln Met Leu Pro Glu Pro Ile Ser Phe
            180                 185                 190         
Glu Ala Ala Ala Ile Pro Val Ala Glu Lys Glu Glu Ala Leu Leu Pro
        195                 200                 205             
Glu Pro Asp Val Pro Thr Asp Thr Lys Glu Ser Ser Glu Lys Asp Ala
    210                 215                 220                 
Leu Thr Gln Tyr Pro Arg Tyr Lys Lys Tyr Gln Leu Ala Cys Thr Lys
225                 230                 235                 240 
Asn Val Tyr Asn Ala Ser Ser His Ser Thr Ser Gly Phe Ala Ser Thr
                245                 250                 255     
Phe Arg Glu Asp Asn Ser Ser Asn Ser Leu Lys Pro Gly Leu Ala Arg
            260                 265                 270         
Gly Gln Ile Lys Ser Glu Pro Pro Ser Glu Glu Asn Glu Glu Glu Ser
        275                 280                 285             
Ile Thr Leu Cys Leu Ser Gly Asp Glu Pro Asp Ala Lys Asp Arg Ala
    290                 295                 300                 
Gly Asp Val Glu Met Asp Arg Lys Gln Pro Ser Pro Ala Pro Thr Pro
305                 310                 315                 320 
Thr Ala Pro Ala Gly Ala Ala Cys Leu Glu Arg Ser Arg Ser Val Ala
                325                 330                 335     
Ser Pro Ser Cys Leu Arg Ser Leu Phe Ser Ile Thr Lys Ser Val Glu
            340                 345                 350         
Leu Ser Gly Leu Pro Ser Thr Ser Gln Gln His Phe Ala Arg Ser Pro
        355                 360                 365             
Ala Cys Pro Phe Asp Lys Gly Ile Thr Gln Gly Asp Leu Lys Thr Asp
    370                 375                 380                 
Tyr Thr Pro Phe Thr Gly Asn Tyr Gly Gln Pro His Val Gly Gln Lys
385                 390                 395                 400 
Glu Val Ser Asn Phe Thr Met Gly Ser Pro Leu Arg Gly Pro Gly Leu
                405                 410                 415     
Pro Leu Cys Glu Phe Ser Ser Ser Pro Cys Ser Gln Gly Ala Arg Phe
            420                 425                 430         
Leu Ala Thr Glu His Gln Glu Pro Gly Leu Met Gly Asp Gly Met Tyr
        435                 440                 445             
Asn Gln Val Arg Pro Gln Ile Lys Cys Glu Gln Ser Tyr Gly Thr Asn
    450                 455                 460                 
Ser Ser Asp Glu Ser Gly Ser Phe Ser Glu Ala Asp Ser Glu Ser Cys
465                 470                 475                 480 
Pro Val Gln Asp Arg Gly Gln Glu Val Lys Leu Pro Phe Pro Val Asp
                485                 490                 495     
Gln Ile Thr Asp Leu Pro Arg Asn Asp Phe Gln Met Met Ile Lys Met
            500                 505                 510         
His Lys Leu Thr Ser Glu Gln Leu Glu Phe Ile His Asp Val Arg Arg
        515                 520                 525             
Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys Arg Lys Leu
    530                 535                 540                 
Asp Cys Ile Gln Asn Leu Glu Cys Glu Ile Arg Lys Leu Val Cys Glu
545                 550                 555                 560 
Lys Glu Lys Leu Leu Ser Glu Arg Asn Gln Leu Lys Ala Cys Met Gly
                565                 570                 575     
Glu Leu Leu Asp Asn Phe Ser Cys Leu Ser Gln Glu Val Cys Arg Asp
            580                 585                 590         
Ile Gln Ser Pro Glu Gln Ile Gln Ala Leu His Arg Tyr Cys Pro Val
        595                 600                 605             
Leu Arg Pro Met Asp Leu Pro Thr Ala Ser Ser Ile Asn Pro Ala Pro
    610                 615                 620                 
Leu Gly Ala Glu Gln Asn Ile Ala Ala Ser Gln Cys Ala Val Gly Glu
625                 630                 635                 640 
Asn Val Pro Cys Cys Leu Glu Pro Gly Ala Ala Pro Pro Gly Pro Pro
                645                 650                 655     
Trp Ala Pro Ser Asn Thr Ser Glu Asn Cys Thr Ser Gly Arg Arg Leu
            660                 665                 670         
Glu Gly Thr Asp Pro Gly Thr Phe Ser Glu Arg Gly Pro Pro Leu Glu
        675                 680                 685             
Pro Arg Ser Gln Thr Val Thr Val Asp Phe Cys Gln Glu Met Thr Asp
    690                 695                 700                 
Lys Cys Thr Thr Asp Glu Gln Pro Arg Lys Asp Tyr Thr
705                 710                 715         


<210> 8441
<211> 841
<212> PRT
<213> Homo sapiens

<400> 8441
Met Ser Val Asp Glu Lys Pro Asp Ser Pro Met Tyr Val Tyr Glu Ser
 1               5                  10                  15      
Thr Val His Cys Thr Asn Ile Leu Leu Gly Leu Asn Asp Gln Arg Lys
            20                  25                  30          
Lys Asp Ile Leu Cys Asp Val Thr Leu Ile Val Glu Arg Lys Glu Phe
        35                  40                  45              
Arg Ala His Arg Ala Val Leu Ala Ala Cys Ser Glu Tyr Phe Trp Gln
    50                  55                  60                  
Ala Leu Val Gly Gln Thr Lys Asn Asp Leu Val Val Ser Leu Pro Glu
65                  70                  75                  80  
Glu Val Thr Ala Arg Gly Phe Gly Pro Leu Leu Gln Phe Ala Tyr Thr
                85                  90                  95      
Ala Lys Leu Leu Leu Ser Arg Glu Asn Ile Arg Glu Val Ile Arg Cys
            100                 105                 110         
Ala Glu Phe Leu Arg Met His Asn Leu Glu Asp Ser Cys Phe Ser Phe
        115                 120                 125             
Leu Gln Thr Gln Leu Leu Asn Ser Glu Asp Gly Leu Phe Val Cys Arg
    130                 135                 140                 
Lys Asp Ala Ala Cys Gln Arg Pro His Glu Asp Cys Glu Asn Ser Ala
145                 150                 155                 160 
Gly Glu Glu Glu Asp Glu Glu Glu Glu Thr Met Asp Ser Glu Thr Ala
                165                 170                 175     
Lys Met Ala Cys Pro Arg Asp Gln Met Leu Pro Glu Pro Ile Ser Phe
            180                 185                 190         
Glu Ala Ala Ala Ile Pro Val Ala Glu Lys Glu Glu Ala Leu Leu Pro
        195                 200                 205             
Glu Pro Asp Val Pro Thr Asp Thr Lys Glu Ser Ser Glu Lys Asp Ala
    210                 215                 220                 
Leu Thr Gln Tyr Pro Arg Tyr Lys Lys Tyr Gln Leu Ala Cys Thr Lys
225                 230                 235                 240 
Asn Val Tyr Asn Ala Ser Ser His Ser Thr Ser Gly Phe Ala Ser Thr
                245                 250                 255     
Phe Arg Glu Asp Asn Ser Ser Asn Ser Leu Lys Pro Gly Leu Ala Arg
            260                 265                 270         
Gly Gln Ile Lys Ser Glu Pro Pro Ser Glu Glu Asn Glu Glu Glu Ser
        275                 280                 285             
Ile Thr Leu Cys Leu Ser Gly Asp Glu Pro Asp Ala Lys Asp Arg Ala
    290                 295                 300                 
Gly Asp Val Glu Met Asp Arg Lys Gln Pro Ser Pro Ala Pro Thr Pro
305                 310                 315                 320 
Thr Ala Pro Ala Gly Ala Ala Cys Leu Glu Arg Ser Arg Ser Val Ala
                325                 330                 335     
Ser Pro Ser Cys Leu Arg Ser Leu Phe Ser Ile Thr Lys Ser Val Glu
            340                 345                 350         
Leu Ser Gly Leu Pro Ser Thr Ser Gln Gln His Phe Ala Arg Ser Pro
        355                 360                 365             
Ala Cys Pro Phe Asp Lys Gly Ile Thr Gln Gly Asp Leu Lys Thr Asp
    370                 375                 380                 
Tyr Thr Pro Phe Thr Gly Asn Tyr Gly Gln Pro His Val Gly Gln Lys
385                 390                 395                 400 
Glu Val Ser Asn Phe Thr Met Gly Ser Pro Leu Arg Gly Pro Gly Leu
                405                 410                 415     
Glu Ala Leu Cys Lys Gln Glu Gly Glu Leu Asp Arg Arg Ser Val Ile
            420                 425                 430         
Phe Ser Ser Ser Ala Cys Asp Gln Val Ser Thr Ser Val His Ser Tyr
        435                 440                 445             
Ser Gly Val Ser Ser Leu Asp Lys Asp Leu Ser Glu Pro Val Pro Lys
    450                 455                 460                 
Gly Leu Trp Val Gly Ala Gly Gln Ser Leu Pro Ser Ser Gln Ala Tyr
465                 470                 475                 480 
Ser His Gly Gly Leu Met Ala Asp His Leu Pro Gly Arg Met Arg Pro
                485                 490                 495     
Asn Thr Ser Cys Pro Val Pro Ile Lys Val Cys Pro Arg Ser Pro Pro
            500                 505                 510         
Leu Glu Thr Arg Thr Arg Thr Ser Ser Ser Cys Ser Ser Tyr Ser Tyr
        515                 520                 525             
Ala Glu Asp Gly Ser Gly Gly Ser Pro Cys Ser Leu Pro Leu Cys Glu
    530                 535                 540                 
Phe Ser Ser Ser Pro Cys Ser Gln Gly Ala Arg Phe Leu Ala Thr Glu
545                 550                 555                 560 
His Gln Glu Pro Gly Leu Met Gly Asp Gly Met Tyr Asn Gln Val Arg
                565                 570                 575     
Pro Gln Ile Lys Cys Glu Gln Ser Tyr Gly Thr Asn Ser Ser Asp Glu
            580                 585                 590         
Ser Gly Ser Phe Ser Glu Ala Asp Ser Glu Ser Cys Pro Val Gln Asp
        595                 600                 605             
Arg Gly Gln Glu Val Lys Leu Pro Phe Pro Val Asp Gln Ile Thr Asp
    610                 615                 620                 
Leu Pro Arg Asn Asp Phe Gln Met Met Ile Lys Met His Lys Leu Thr
625                 630                 635                 640 
Ser Glu Gln Leu Glu Phe Ile His Asp Val Arg Arg Arg Ser Lys Asn
                645                 650                 655     
Arg Ile Ala Ala Gln Arg Cys Arg Lys Arg Lys Leu Asp Cys Ile Gln
            660                 665                 670         
Asn Leu Glu Cys Glu Ile Arg Lys Leu Val Cys Glu Lys Glu Lys Leu
        675                 680                 685             
Leu Ser Glu Arg Asn Gln Leu Lys Ala Cys Met Gly Glu Leu Leu Asp
    690                 695                 700                 
Asn Phe Ser Cys Leu Ser Gln Glu Val Cys Arg Asp Ile Gln Ser Pro
705                 710                 715                 720 
Glu Gln Ile Gln Ala Leu His Arg Tyr Cys Pro Val Leu Arg Pro Met
                725                 730                 735     
Asp Leu Pro Thr Ala Ser Ser Ile Asn Pro Ala Pro Leu Gly Ala Glu
            740                 745                 750         
Gln Asn Ile Ala Ala Ser Gln Cys Ala Val Gly Glu Asn Val Pro Cys
        755                 760                 765             
Cys Leu Glu Pro Gly Ala Ala Pro Pro Gly Pro Pro Trp Ala Pro Ser
    770                 775                 780                 
Asn Thr Ser Glu Asn Cys Thr Ser Gly Arg Arg Leu Glu Gly Thr Asp
785                 790                 795                 800 
Pro Gly Thr Phe Ser Glu Arg Gly Pro Pro Leu Glu Pro Arg Ser Gln
                805                 810                 815     
Thr Val Thr Val Asp Phe Cys Gln Glu Met Thr Asp Lys Cys Thr Thr
            820                 825                 830         
Asp Glu Gln Pro Arg Lys Asp Tyr Thr
        835                 840     


<210> 8442
<211> 384
<212> PRT
<213> Homo sapiens

<400> 8442
Met Lys Val Thr Ser Leu Asp Gly Arg Gln Leu Arg Lys Met Leu Arg
 1               5                  10                  15      
Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu
            20                  25                  30          
Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn
        35                  40                  45              
Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr
    50                  55                  60                  
Val Leu Pro Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly
65                  70                  75                  80  
Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp
                85                  90                  95      
Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu
            100                 105                 110         
Leu Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly
        115                 120                 125             
Tyr Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys
    130                 135                 140                 
Pro Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln
145                 150                 155                 160 
Cys Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln
                165                 170                 175     
Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr
            180                 185                 190         
His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu
        195                 200                 205             
Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Met Thr His Leu His
    210                 215                 220                 
Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser
225                 230                 235                 240 
His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly
                245                 250                 255     
Gly Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr
            260                 265                 270         
Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu
        275                 280                 285             
Ala Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe
    290                 295                 300                 
Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser
305                 310                 315                 320 
Thr Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser
                325                 330                 335     
Ser Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala
            340                 345                 350         
Tyr Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser
        355                 360                 365             
Thr Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Thr Ser Cys
    370                 375                 380                 


<210> 8443
<211> 697
<212> PRT
<213> Homo sapiens

<400> 8443
Met Ala Glu Thr Ser Pro Glu Pro Ser Gly Gln Leu Val Val His Ser
 1               5                  10                  15      
Asp Ala His Ser Asp Thr Val Leu Ala Ser Phe Glu Asp Gln Arg Lys
            20                  25                  30          
Lys Gly Phe Leu Cys Asp Ile Thr Leu Ile Val Glu Asn Val His Phe
        35                  40                  45              
Arg Ala His Lys Ala Leu Leu Ala Ala Ser Ser Glu Tyr Phe Ser Met
    50                  55                  60                  
Met Phe Ala Glu Glu Gly Glu Ile Gly Gln Ser Ile Tyr Met Leu Glu
65                  70                  75                  80  
Gly Met Val Ala Asp Thr Phe Gly Ile Leu Leu Glu Phe Ile Tyr Thr
                85                  90                  95      
Gly Tyr Leu His Ala Ser Glu Lys Ser Thr Glu Gln Ile Leu Ala Thr
            100                 105                 110         
Ala Gln Phe Leu Lys Val Tyr Asp Leu Val Lys Ala Tyr Thr Asp Phe
        115                 120                 125             
Gln Asn Asn His Ser Ser Pro Lys Pro Thr Thr Leu Asn Thr Ala Gly
    130                 135                 140                 
Ala Pro Val Val Val Ile Pro Asn Lys Lys Asn Asp Pro Pro Lys Arg
145                 150                 155                 160 
Lys Arg Gly Arg Pro Lys Lys Val Asn Thr Leu Gln Glu Glu Lys Ser
                165                 170                 175     
Glu Leu Ala Ala Glu Glu Glu Ile Gln Leu Arg Val Asn Asn Ser Val
            180                 185                 190         
Gln Asn Arg Gln Asn Phe Val Val Lys Gly Asp Ser Gly Val Leu Asn
        195                 200                 205             
Glu Gln Ile Ala Ala Lys Glu Lys Glu Glu Ser Glu Pro Thr Cys Glu
    210                 215                 220                 
Pro Ser Arg Glu Glu Glu Met Pro Val Glu Lys Asp Glu Asn Tyr Asp
225                 230                 235                 240 
Pro Lys Thr Glu Asp Gly Gln Ala Ser Gln Ser Arg Tyr Ser Lys Arg
                245                 250                 255     
Arg Ile Trp Arg Ser Val Lys Leu Lys Asp Tyr Lys Leu Val Gly Asp
            260                 265                 270         
Gln Glu Asp His Gly Ser Ala Lys Arg Ile Cys Gly Arg Arg Lys Arg
        275                 280                 285             
Pro Gly Gly Pro Glu Ala Arg Cys Lys Asp Cys Gly Lys Val Phe Lys
    290                 295                 300                 
Tyr Asn His Phe Leu Ala Ile His Gln Arg Ser His Thr Gly Glu Arg
305                 310                 315                 320 
Pro Phe Lys Cys Asn Glu Cys Gly Lys Gly Phe Ala Gln Lys His Ser
                325                 330                 335     
Leu Gln Val His Thr Arg Met His Thr Gly Glu Arg Pro Tyr Thr Cys
            340                 345                 350         
Thr Val Cys Ser Lys Ala Leu Thr Thr Lys His Ser Leu Leu Glu His
        355                 360                 365             
Met Ser Leu His Ser Gly Gln Lys Ser Phe Thr Cys Asp Gln Cys Gly
    370                 375                 380                 
Lys Tyr Phe Ser Gln Asn Arg Gln Leu Lys Ser His Tyr Arg Val His
385                 390                 395                 400 
Thr Gly His Ser Leu Pro Glu Cys Lys Asp Cys His Arg Lys Phe Met
                405                 410                 415     
Asp Val Ser Gln Leu Lys Lys His Leu Arg Thr His Thr Gly Glu Lys
            420                 425                 430         
Pro Phe Thr Cys Glu Ile Cys Gly Lys Ser Phe Thr Ala Lys Ser Ser
        435                 440                 445             
Leu Gln Thr His Ile Arg Ile His Arg Gly Glu Lys Pro Tyr Ser Cys
    450                 455                 460                 
Gly Ile Cys Gly Lys Ser Phe Ser Asp Ser Ser Ala Lys Arg Arg His
465                 470                 475                 480 
Cys Ile Leu His Thr Gly Lys Lys Pro Phe Ser Cys Pro Glu Cys Asn
                485                 490                 495     
Leu Gln Phe Ala Arg Leu Asp Asn Leu Lys Ala His Leu Lys Ile His
            500                 505                 510         
Ser Lys Glu Lys His Ala Ser Asp Ala Ser Ser Ile Ser Gly Ser Ser
        515                 520                 525             
Asn Thr Glu Glu Val Arg Asn Ile Leu Gln Leu Gln Pro Tyr Gln Leu
    530                 535                 540                 
Ser Thr Ser Gly Glu Gln Glu Ile Gln Leu Leu Val Thr Asp Ser Val
545                 550                 555                 560 
His Asn Ile Asn Phe Met Pro Gly Pro Ser Gln Gly Ile Ser Ile Val
                565                 570                 575     
Thr Ala Glu Ser Ser Gln Asn Met Thr Ala Asp Gln Ala Ala Asn Leu
            580                 585                 590         
Thr Leu Leu Thr Gln Gln Pro Glu Gln Leu Gln Asn Leu Ile Leu Ser
        595                 600                 605             
Ala Gln Gln Glu Gln Thr Glu His Ile Gln Ser Leu Asn Met Ile Glu
    610                 615                 620                 
Ser Gln Met Gly Pro Ser Gln Thr Glu Pro Val His Val Ile Thr Leu
625                 630                 635                 640 
Ser Lys Glu Thr Leu Glu His Leu His Ala His Gln Glu Gln Thr Glu
                645                 650                 655     
Glu Leu His Leu Ala Thr Ser Thr Ser Asp Pro Ala Gln His Leu Gln
            660                 665                 670         
Leu Thr Gln Glu Pro Gly Pro Pro Pro Pro Thr His His Val Pro Gln
        675                 680                 685             
Pro Thr Pro Leu Gly Gln Glu Gln Ser
    690                 695         


<210> 8444
<211> 331
<212> PRT
<213> Homo sapiens

<400> 8444
Met Pro Ser Leu Gln Leu Glu Val Trp Arg Arg Gln Gln His Asn His
 1               5                  10                  15      
Tyr Ala Phe Leu Phe Val Val Val Thr His Lys Gly Tyr Ser Ser Arg
            20                  25                  30          
Ala Asn Pro Lys Ala Tyr Ile His Ala Gln Ala Glu Asn Cys Ser His
        35                  40                  45              
Thr Ala Glu Leu Val Ser Trp Lys Arg Glu Arg Ile Arg Asp Gly Gln
    50                  55                  60                  
Asp Gly Ala Ser Arg Gly Cys Phe Arg Lys Asp Met Val Leu Asn Glu
65                  70                  75                  80  
Ser His Ser Glu Gly Ser Arg Val Ile Ala Asn Asn Thr Glu Ser Ile
                85                  90                  95      
Pro Met Pro Tyr Asp His Val Lys Leu Thr Phe Ser Asp Met Asn Asn
            100                 105                 110         
Val Pro Glu Ala Ser Lys Gly Thr Lys Lys Gly Thr Ile Tyr Leu Thr
        115                 120                 125             
Pro Phe Ile Phe Leu Ser Arg Ala Lys Asp Ala Thr Gln Ser Phe Val
    130                 135                 140                 
Met Ser Phe Tyr Leu Leu Lys Ala Tyr Glu Ile Lys Gln Pro Val Phe
145                 150                 155                 160 
Asp Thr Asn Cys Ile Lys Gly Thr Val Asn Thr Glu Ala Gly Gly Gly
                165                 170                 175     
Trp Glu Gly Ser Ala Ser Gly Lys Ser Ala Phe Thr Ala Gly Gly Ala
            180                 185                 190         
Thr Glu Ser Gly Gln Gln Val Leu Gln Val Thr Ser Gln Ala Ser Arg
        195                 200                 205             
Gly Glu Ala Leu Ser Gly Ala Tyr Gly His Ser His Val Pro Gly Arg
    210                 215                 220                 
Thr Cys Val Phe Pro Pro Pro Val Thr Ser Gly Met Tyr Pro Cys Pro
225                 230                 235                 240 
Pro Gly Cys Pro Ser Pro Pro Pro Ser Pro Glu Phe Tyr Pro Gly Pro
                245                 250                 255     
Pro Lys Met Asp Arg Ala Met Gly Tyr Val Gln Pro Pro Pro Leu Pro
            260                 265                 270         
Cys Pro Gly Pro Met Glu Pro Pro Val Ser Pro Asp Val Pro Cys Thr
        275                 280                 285             
Pro Ala Ala Glu Ala Arg Ala Thr Lys Ala Ala Ala Ser Thr Tyr Tyr
    290                 295                 300                 
Asn Pro Gly Lys Pro His His Val Ser Met Pro Thr Lys Gln Pro Pro
305                 310                 315                 320 
Pro Ser Tyr Pro Arg Glu Asp Lys Lys Thr Gln
                325                 330     


<210> 8445
<211> 145
<212> PRT
<213> Homo sapiens

<400> 8445
Ile Lys Thr Lys Thr Lys Tyr Lys Thr Ala Ala Gly Ile Thr Pro Thr
 1               5                  10                  15      
Leu Pro Pro Gln Val Ser Gly Phe Arg Leu Lys Lys Thr Cys Ile Phe
            20                  25                  30          
Leu Gly Cys Ala Ile Ile Arg Asn Tyr Arg Gly Pro Gln Arg Pro Thr
        35                  40                  45              
Gln Cys Asp Ser Gln Arg Glu Arg Ser Trp Asn Lys Asp Arg Glu Trp
    50                  55                  60                  
Gly Gly Cys Gly Ser Ser Trp Glu Arg Ala Lys Ala Tyr Ala Gly Arg
65                  70                  75                  80  
Lys Gln His Tyr Ile Ala Gly Asn Cys Ser Ser Asn Gly Arg Gly Trp
                85                  90                  95      
Val Leu Pro His His Pro Ser Ala Leu Asp Leu Cys Pro Arg Ser Glu
            100                 105                 110         
Pro Ser Glu Ile Leu Gly Glu Leu Ser Thr Thr Ala Ser Leu Arg Asn
        115                 120                 125             
Leu Glu Thr Leu Gly Ser Arg Ser Pro Trp Arg Met Lys Gly Thr Val
    130                 135                 140                 
Ala
145 


<210> 8446
<211> 1409
<212> PRT
<213> Homo sapiens

<400> 8446
Met Asp Trp Tyr Gln Thr Arg Ala Glu Glu Ile Glu His Tyr Ala Arg
 1               5                  10                  15      
Gln Leu Gln Gln Lys Ile Ile Pro Asp Gln Asp Gln Leu Met Ala Ile
            20                  25                  30          
Ala Leu Glu Cys Ile Tyr Thr Cys Glu Arg Asn Asp Gln Leu Cys Leu
        35                  40                  45              
Cys Tyr Asp Leu Leu Glu Cys Leu Pro Glu Arg Gly Tyr Gly Asp Lys
    50                  55                  60                  
Thr Glu Ala Thr Thr Lys Leu His Asp Met Val Asp Gln Leu Glu Gln
65                  70                  75                  80  
Ile Leu Ser Val Ser Glu Leu Leu Glu Lys His Gly Leu Glu Lys Pro
                85                  90                  95      
Ile Ser Phe Val Lys Asn Thr Gln Ser Ser Ser Glu Glu Ala Arg Lys
            100                 105                 110         
Leu Met Val Arg Leu Thr Arg His Thr Gly Arg Lys Gln Pro Pro Val
        115                 120                 125             
Ser Glu Ser His Trp Arg Thr Leu Leu Gln Asp Met Leu Thr Met Gln
    130                 135                 140                 
Gln Asn Val Tyr Thr Cys Leu Asp Ser Asp Ala Cys Tyr Glu Ile Phe
145                 150                 155                 160 
Thr Glu Ser Leu Leu Cys Ser Ser Arg Leu Glu Asn Ile His Leu Ala
                165                 170                 175     
Gly Gln Met Met His Cys Ser Ala Cys Ser Glu Asn Pro Pro Ala Gly
            180                 185                 190         
Ile Ala His Lys Gly Lys Pro His Tyr Arg Val Ser Tyr Glu Lys Ser
        195                 200                 205             
Ile Asp Leu Val Leu Ala Ala Ser Arg Glu Tyr Phe Asn Ser Ser Thr
    210                 215                 220                 
Asn Leu Thr Asp Ser Cys Met Asp Leu Ala Arg Cys Cys Leu Gln Leu
225                 230                 235                 240 
Ile Thr Asp Arg Pro Pro Ala Ile Gln Glu Glu Leu Asp Leu Ile Gln
                245                 250                 255     
Ala Val Gly Cys Leu Glu Glu Phe Gly Val Lys Ile Leu Pro Leu Gln
            260                 265                 270         
Val Arg Leu Cys Pro Asp Arg Ile Ser Leu Ile Lys Glu Cys Ile Ser
        275                 280                 285             
Gln Ser Pro Thr Cys Tyr Lys Gln Ser Thr Lys Leu Leu Gly Leu Ala
    290                 295                 300                 
Glu Leu Leu Arg Val Ala Gly Glu Asn Pro Glu Glu Arg Arg Gly Gln
305                 310                 315                 320 
Val Leu Ile Leu Leu Val Glu Gln Ala Leu Arg Phe His Asp Tyr Lys
                325                 330                 335     
Ala Ala Ser Met His Cys Gln Glu Leu Met Ala Thr Gly Tyr Pro Lys
            340                 345                 350         
Ser Trp Asp Val Cys Ser Gln Leu Gly Gln Ser Glu Gly Tyr Gln Asp
        355                 360                 365             
Leu Ala Thr Arg Gln Glu Leu Met Ala Phe Ala Leu Thr His Cys Pro
    370                 375                 380                 
Pro Ser Ser Ile Glu Leu Leu Leu Ala Ala Ser Ser Ser Leu Gln Thr
385                 390                 395                 400 
Glu Ile Leu Tyr Gln Arg Val Asn Phe Gln Ile His His Glu Gly Gly
                405                 410                 415     
Glu Asn Ile Ser Ala Ser Pro Leu Thr Ser Lys Ala Val Gln Glu Asp
            420                 425                 430         
Glu Val Gly Val Pro Gly Ser Asn Ser Ala Asp Leu Leu Arg Trp Thr
        435                 440                 445             
Thr Ala Thr Thr Met Lys Val Leu Ser Asn Thr Thr Thr Thr Thr Lys
    450                 455                 460                 
Ala Val Leu Gln Ala Val Ser Asp Gly Gln Trp Trp Lys Lys Ser Leu
465                 470                 475                 480 
Thr Tyr Leu Arg Pro Leu Gln Gly Gln Lys Cys Gly Gly Ala Tyr Gln
                485                 490                 495     
Ile Gly Thr Thr Ala Asn Glu Asp Leu Glu Lys Gln Gly Cys His Pro
            500                 505                 510         
Phe Tyr Glu Ser Val Ile Ser Asn Pro Phe Val Ala Glu Ser Glu Gly
        515                 520                 525             
Thr Tyr Asp Thr Tyr Gln His Val Pro Val Glu Ser Phe Ala Glu Val
    530                 535                 540                 
Leu Leu Arg Thr Gly Lys Leu Ala Glu Ala Lys Asn Lys Gly Glu Val
545                 550                 555                 560 
Phe Pro Thr Thr Glu Val Leu Leu Gln Leu Ala Ser Glu Ala Leu Pro
                565                 570                 575     
Asn Asp Met Thr Leu Ala Leu Ala Tyr Leu Leu Ala Leu Pro Gln Val
            580                 585                 590         
Leu Asp Ala Asn Arg Cys Phe Glu Lys Gln Ser Pro Ser Ala Leu Ser
        595                 600                 605             
Leu Gln Leu Ala Ala Tyr Tyr Tyr Ser Leu Gln Ile Tyr Ala Arg Leu
    610                 615                 620                 
Ala Pro Cys Phe Arg Asp Lys Cys His Pro Leu Tyr Arg Ala Asp Pro
625                 630                 635                 640 
Lys Glu Leu Ile Lys Met Val Thr Arg His Val Thr Arg His Glu His
                645                 650                 655     
Glu Ala Trp Pro Glu Asp Leu Ile Ser Leu Thr Lys Gln Leu His Cys
            660                 665                 670         
Tyr Asn Glu Arg Leu Leu Asp Phe Thr Gln Ala Gln Ile Leu Gln Gly
        675                 680                 685             
Leu Arg Lys Gly Val Asp Val Gln Arg Phe Thr Ala Asp Asp Gln Tyr
    690                 695                 700                 
Lys Arg Glu Thr Ile Leu Gly Leu Ala Glu Thr Leu Glu Glu Ser Val
705                 710                 715                 720 
Tyr Ser Ile Ala Ile Ser Leu Ala Gln Arg Tyr Ser Val Ser Arg Trp
                725                 730                 735     
Glu Val Phe Met Thr His Leu Glu Phe Leu Phe Thr Asp Ser Gly Leu
            740                 745                 750         
Ser Thr Leu Glu Ile Glu Asn Arg Ala Gln Asp Leu His Leu Phe Glu
        755                 760                 765             
Thr Leu Lys Thr Asp Pro Glu Ala Phe His Gln His Met Val Lys Tyr
    770                 775                 780                 
Ile Tyr Pro Thr Ile Gly Gly Phe Asp His Glu Arg Leu Gln Tyr Tyr
785                 790                 795                 800 
Phe Thr Leu Leu Glu Asn Cys Gly Cys Ala Asp Leu Gly Asn Cys Ala
                805                 810                 815     
Ile Lys Pro Glu Thr His Ile Arg Leu Leu Lys Lys Phe Lys Val Val
            820                 825                 830         
Ala Ser Gly Leu Asn Tyr Lys Lys Leu Thr Asp Glu Asn Met Ser Pro
        835                 840                 845             
Leu Glu Ala Leu Glu Pro Val Leu Ser Ser Gln Asn Ile Leu Ser Ile
    850                 855                 860                 
Ser Lys Leu Val Pro Lys Ile Pro Glu Lys Asp Gly Gln Met Leu Ser
865                 870                 875                 880 
Pro Ser Ser Leu Tyr Thr Ile Trp Leu Gln Lys Leu Phe Trp Thr Gly
                885                 890                 895     
Asp Pro His Leu Ile Lys Gln Val Pro Gly Ser Ser Pro Glu Trp Leu
            900                 905                 910         
His Ala Tyr Asp Val Cys Met Lys Tyr Phe Asp Arg Leu His Pro Gly
        915                 920                 925             
Asp Leu Ile Thr Val Val Asp Ala Val Thr Phe Ser Pro Lys Ala Val
    930                 935                 940                 
Thr Lys Leu Ser Val Glu Ala Arg Lys Glu Met Thr Arg Lys Ala Ile
945                 950                 955                 960 
Lys Thr Val Lys His Phe Ile Glu Lys Pro Arg Lys Arg Asn Ser Glu
                965                 970                 975     
Asp Glu Ala Gln Glu Ala Lys Asp Ser Lys Val Thr Tyr Ala Asp Thr
            980                 985                 990         
Leu Asn His Leu Glu Lys Ser Leu Ala His Leu Glu Thr Leu Ser His
        995                 1000                1005            
Ser Phe Ile Leu Ser Leu Lys Asn Ser Glu Gln Glu Thr Leu Gln Lys
    1010                1015                1020                
Tyr Ser His Leu Tyr Asp Leu Ser Arg Ser Glu Lys Glu Lys Leu His
1025                1030                1035                1040
Asp Glu Ala Val Ala Ile Cys Leu Asp Gly Gln Pro Leu Ala Met Ile
                1045                1050                1055    
Gln Gln Leu Leu Glu Val Ala Val Gly Pro Leu Asp Ile Ser Pro Lys
            1060                1065                1070        
Asp Ile Val Gln Ser Ala Ile Met Lys Ile Ile Ser Ala Leu Ser Gly
        1075                1080                1085            
Gly Ser Ala Asp Leu Gly Gly Pro Arg Asp Pro Leu Lys Val Leu Glu
    1090                1095                1100                
Gly Val Val Ala Ala Val His Thr Ser Val Asp Lys Gly Glu Glu Leu
1105                1110                1115                1120
Val Ser Pro Glu Asp Leu Leu Glu Trp Leu Arg Pro Phe Cys Ala Asp
                1125                1130                1135    
Asp Ala Trp Pro Val Arg Pro Arg Ile His Val Leu Gln Ile Leu Gly
            1140                1145                1150        
Gln Ser Phe His Leu Thr Glu Glu Asp Ser Lys Leu Leu Val Phe Phe
        1155                1160                1165            
Arg Thr Glu Ala Ile Leu Lys Ala Ser Trp Pro Gln Arg Gln Val Asp
    1170                1175                1180                
Ile Ala Asp Ile Glu Asn Glu Glu Asn Arg Tyr Cys Leu Phe Met Glu
1185                1190                1195                1200
Leu Leu Glu Ser Ser His His Glu Ala Glu Phe Gln His Leu Val Leu
                1205                1210                1215    
Leu Leu Gln Ala Trp Pro Pro Met Lys Ser Glu Tyr Val Ile Thr Asn
            1220                1225                1230        
Asn Pro Trp Val Arg Leu Ala Thr Val Met Leu Thr Arg Cys Thr Met
        1235                1240                1245            
Glu Asn Lys Glu Gly Leu Gly Asn Glu Val Leu Lys Met Cys Arg Ser
    1250                1255                1260                
Leu Tyr Asn Thr Lys Gln Met Leu Pro Ala Glu Gly Val Lys Glu Leu
1265                1270                1275                1280
Cys Leu Leu Leu Leu Asn Gln Ser Leu Leu Leu Pro Ser Leu Lys Leu
                1285                1290                1295    
Leu Leu Glu Ser Arg Asp Glu His Leu His Glu Met Ala Leu Glu Gln
            1300                1305                1310        
Ile Thr Ala Val Thr Thr Val Asn Asp Ser Asn Cys Asp Gln Glu Leu
        1315                1320                1325            
Leu Ser Leu Leu Leu Asp Ala Lys Leu Leu Val Lys Cys Val Ser Thr
    1330                1335                1340                
Pro Phe Tyr Pro Arg Ile Val Asp His Leu Leu Ala Ser Leu Gln Gln
1345                1350                1355                1360
Gly Arg Trp Asp Ala Glu Glu Leu Gly Arg His Leu Arg Glu Ala Gly
                1365                1370                1375    
His Glu Ala Glu Ala Gly Ser Leu Leu Leu Ala Val Arg Gly Thr His
            1380                1385                1390        
Gln Ala Phe Arg Thr Phe Ser Thr Ala Leu Arg Ala Ala Gln His Trp
        1395                1400                1405            
Val
    


<210> 8447
<211> 594
<212> PRT
<213> Homo sapiens

<400> 8447
Met Gly Lys Lys Ser Arg Val Lys Thr Gln Lys Ser Gly Thr Gly Ala
 1               5                  10                  15      
Thr Ala Thr Val Ser Pro Lys Glu Ile Leu Asn Leu Thr Ser Glu Leu
            20                  25                  30          
Leu Gln Lys Cys Ser Ser Pro Ala Pro Gly Pro Gly Lys Glu Trp Glu
        35                  40                  45              
Glu Tyr Val Gln Ile Arg Thr Leu Val Glu Lys Ile Arg Lys Lys Gln
    50                  55                  60                  
Lys Gly Leu Ser Val Thr Phe Asp Gly Lys Arg Glu Asp Tyr Phe Pro
65                  70                  75                  80  
Asp Leu Met Lys Trp Ala Ser Glu Asn Gly Ala Ser Val Glu Gly Phe
                85                  90                  95      
Glu Met Val Asn Phe Lys Glu Glu Gly Phe Gly Leu Arg Ala Thr Arg
            100                 105                 110         
Asp Ile Lys Ala Glu Glu Leu Phe Leu Trp Val Pro Arg Lys Leu Leu
        115                 120                 125             
Met Thr Val Glu Ser Ala Lys Asn Ser Val Leu Gly Pro Leu Tyr Ser
    130                 135                 140                 
Gln Asp Arg Ile Leu Gln Ala Met Gly Asn Ile Ala Leu Ala Phe His
145                 150                 155                 160 
Leu Leu Cys Glu Arg Ala Ser Pro Asn Ser Phe Trp Gln Pro Tyr Ile
                165                 170                 175     
Gln Thr Leu Pro Ser Glu Tyr Asp Thr Pro Leu Tyr Phe Glu Glu Asp
            180                 185                 190         
Glu Val Arg Tyr Leu Gln Ser Thr Gln Ala Ile His Asp Val Phe Ser
        195                 200                 205             
Gln Tyr Lys Asn Thr Ala Arg Gln Tyr Ala Tyr Phe Tyr Lys Val Ile
    210                 215                 220                 
Gln Thr His Pro His Ala Asn Lys Leu Pro Leu Lys Asp Ser Phe Thr
225                 230                 235                 240 
Tyr Glu Asp Tyr Arg Trp Ala Val Ser Ser Val Met Thr Arg Gln Asn
                245                 250                 255     
Gln Ile Pro Thr Glu Asp Gly Ser Arg Val Thr Leu Ala Leu Ile Pro
            260                 265                 270         
Leu Trp Asp Met Cys Asn His Thr Asn Gly Leu Ile Thr Thr Gly Tyr
        275                 280                 285             
Asn Leu Glu Asp Asp Arg Cys Glu Cys Val Ala Leu Gln Asp Phe Arg
    290                 295                 300                 
Ala Gly Glu Gln Ile Tyr Ile Phe Tyr Gly Thr Arg Ser Asn Ala Glu
305                 310                 315                 320 
Phe Val Ile His Ser Gly Phe Phe Phe Asp Asn Asn Ser His Asp Arg
                325                 330                 335     
Val Lys Ile Lys Leu Gly Val Ser Lys Ser Asp Arg Leu Tyr Ala Met
            340                 345                 350         
Lys Ala Glu Val Leu Ala Arg Ala Gly Ile Pro Thr Ser Ser Val Phe
        355                 360                 365             
Ala Leu His Phe Thr Glu Pro Pro Ile Ser Ala Gln Leu Leu Ala Phe
    370                 375                 380                 
Leu Arg Val Phe Cys Met Thr Glu Glu Glu Leu Lys Glu His Leu Leu
385                 390                 395                 400 
Gly Asp Ser Ala Ile Asp Arg Ile Phe Thr Leu Gly Asn Ser Glu Phe
                405                 410                 415     
Pro Val Ser Trp Asp Asn Glu Val Lys Leu Trp Thr Phe Leu Glu Asp
            420                 425                 430         
Arg Ala Ser Leu Leu Leu Lys Thr Tyr Lys Thr Thr Ile Glu Glu Asp
        435                 440                 445             
Lys Ser Val Leu Lys Asn His Asp Leu Ser Val Arg Ala Lys Met Ala
    450                 455                 460                 
Ile Lys Leu Arg Leu Gly Glu Lys Glu Ile Leu Glu Lys Ala Val Lys
465                 470                 475                 480 
Ser Ala Ala Val Asn Arg Glu Tyr Tyr Arg Gln Gln Met Glu Glu Lys
                485                 490                 495     
Ala Pro Leu Pro Lys Tyr Glu Glu Ser Asn Leu Gly Leu Leu Glu Ser
            500                 505                 510         
Ser Val Gly Asp Ser Arg Leu Pro Leu Val Leu Arg Asn Leu Glu Glu
        515                 520                 525             
Glu Ala Gly Val Gln Asp Ala Leu Asn Ile Arg Glu Ala Ile Ser Lys
    530                 535                 540                 
Ala Lys Ala Thr Glu Asn Gly Leu Val Asn Gly Glu Asn Ser Ile Pro
545                 550                 555                 560 
Asn Gly Thr Arg Ser Glu Asn Glu Ser Leu Asn Gln Glu Ser Lys Arg
                565                 570                 575     
Ala Val Glu Asp Ala Lys Gly Ser Ser Ser Asp Ser Thr Ala Gly Val
            580                 585                 590         
Lys Glu
        


<210> 8448
<211> 766
<212> PRT
<213> Homo sapiens

<400> 8448
Ser Met Ala Gly Phe Lys Arg Gly Tyr Asp Gly Lys Ile Ala Gly Leu
 1               5                  10                  15      
Tyr Asp Leu Asp Lys Thr Leu Gly Arg Gly His Phe Ala Val Val Lys
            20                  25                  30          
Leu Ala Arg His Val Phe Thr Gly Glu Lys Val Ala Val Lys Val Ile
        35                  40                  45              
Asp Lys Thr Lys Leu Asp Thr Leu Ala Thr Gly His Leu Phe Gln Glu
    50                  55                  60                  
Val Arg Cys Met Lys Leu Val Gln His Pro Asn Ile Val Arg Leu Tyr
65                  70                  75                  80  
Glu Val Ile Asp Thr Gln Thr Lys Leu Tyr Leu Ile Leu Glu Leu Gly
                85                  90                  95      
Asp Gly Gly Asp Met Phe Asp Tyr Ile Met Lys His Glu Glu Gly Leu
            100                 105                 110         
Asn Glu Asp Leu Ala Lys Lys Tyr Phe Ala Gln Ile Val His Ala Ile
        115                 120                 125             
Ser Tyr Cys His Lys Leu His Val Val His Arg Asp Leu Lys Pro Glu
    130                 135                 140                 
Asn Val Val Phe Phe Glu Lys Gln Gly Leu Val Lys Leu Thr Asp Phe
145                 150                 155                 160 
Gly Phe Ser Asn Lys Phe Gln Pro Gly Lys Lys Leu Thr Thr Ser Cys
                165                 170                 175     
Gly Ser Leu Ala Tyr Ser Ala Pro Glu Ile Leu Leu Gly Asp Glu Tyr
            180                 185                 190         
Asp Ala Pro Ala Val Asp Ile Trp Ser Leu Gly Val Ile Leu Phe Met
        195                 200                 205             
Leu Val Cys Gly Gln Pro Pro Phe Gln Glu Ala Asn Asp Ser Glu Thr
    210                 215                 220                 
Leu Thr Met Ile Met Asp Cys Lys Tyr Thr Val Pro Ser His Val Ser
225                 230                 235                 240 
Lys Glu Cys Lys Asp Leu Ile Thr Arg Met Leu Gln Arg Asp Pro Lys
                245                 250                 255     
Arg Arg Ala Ser Leu Glu Glu Ile Glu Asn His Pro Trp Leu Gln Gly
            260                 265                 270         
Val Asp Pro Ser Pro Ala Thr Lys Tyr Asn Ile Pro Leu Val Ser Tyr
        275                 280                 285             
Lys Asn Leu Ser Glu Glu Glu His Asn Ser Ile Ile Gln Arg Met Val
    290                 295                 300                 
Leu Gly Asp Ile Ala Asp Arg Asp Ala Ile Val Glu Ala Leu Glu Thr
305                 310                 315                 320 
Asn Arg Tyr Asn His Ile Thr Ala Thr Tyr Phe Leu Leu Ala Glu Arg
                325                 330                 335     
Ile Leu Arg Glu Lys Gln Glu Lys Glu Ile Gln Thr Arg Ser Ala Ser
            340                 345                 350         
Pro Ser Asn Ile Lys Ala Gln Phe Arg Gln Ser Trp Pro Thr Lys Ile
        355                 360                 365             
Asp Val Pro Gln Asp Leu Glu Asp Asp Leu Thr Ala Thr Pro Leu Ser
    370                 375                 380                 
His Ala Thr Val Pro Gln Ser Pro Ala Arg Ala Ala Asp Ser Val Leu
385                 390                 395                 400 
Asn Gly His Arg Ser Lys Gly Leu Cys Asp Ser Ala Lys Lys Asp Asp
                405                 410                 415     
Leu Pro Glu Leu Ala Gly Pro Ala Leu Ser Thr Val Pro Pro Ala Ser
            420                 425                 430         
Leu Lys Pro Thr Ala Ser Gly Arg Lys Cys Leu Phe Arg Val Glu Glu
        435                 440                 445             
Asp Glu Glu Glu Asp Glu Glu Asp Lys Lys Pro Met Ser Leu Ser Thr
    450                 455                 460                 
Gln Val Val Leu Arg Arg Lys Pro Ser Val Thr Asn Arg Leu Thr Ser
465                 470                 475                 480 
Arg Lys Ser Ala Pro Val Leu Asn Gln Ile Phe Glu Glu Gly Glu Ser
                485                 490                 495     
Asp Asp Glu Phe Asp Met Asp Glu Asn Leu Pro Pro Lys Leu Ser Arg
            500                 505                 510         
Leu Lys Met Asn Ile Ala Ser Pro Gly Thr Val His Lys Arg Tyr His
        515                 520                 525             
Arg Arg Lys Ser Gln Gly Arg Gly Ser Ser Cys Ser Ser Ser Glu Thr
    530                 535                 540                 
Ser Asp Asp Asp Ser Glu Ser Arg Arg Arg Leu Asp Lys Asp Ser Gly
545                 550                 555                 560 
Phe Thr Tyr Ser Trp His Arg Arg Asp Ser Ser Glu Gly Pro Pro Gly
                565                 570                 575     
Ser Glu Gly Asp Gly Gly Gly Gln Ser Lys Pro Ser Asn Ala Ser Gly
            580                 585                 590         
Gly Val Asp Lys Ala Ser Pro Ser Glu Asn Asn Ala Gly Gly Gly Ser
        595                 600                 605             
Pro Ser Ser Gly Ser Gly Gly Asn Pro Thr Asn Thr Ser Gly Thr Thr
    610                 615                 620                 
Arg Arg Cys Ala Gly Pro Ser Asn Ser Met Gln Leu Ala Ser Arg Ser
625                 630                 635                 640 
Ala Gly Glu Leu Val Glu Ser Leu Lys Leu Met Ser Leu Cys Leu Gly
                645                 650                 655     
Ser Gln Leu His Gly Ser Thr Lys Tyr Ile Ile Asp Pro Gln Asn Gly
            660                 665                 670         
Leu Ser Phe Ser Ser Val Lys Val Gln Glu Lys Ser Thr Trp Lys Met
        675                 680                 685             
Cys Ile Ser Ser Thr Gly Asn Ala Gly Gln Val Pro Ala Val Gly Gly
    690                 695                 700                 
Ile Lys Phe Phe Ser Asp His Met Ala Asp Thr Thr Thr Glu Leu Glu
705                 710                 715                 720 
Arg Ile Lys Ser Lys Asn Leu Lys Asn Asn Val Leu Gln Leu Pro Leu
                725                 730                 735     
Cys Glu Lys Thr Ile Ser Val Asn Ile Gln Arg Asn Pro Lys Glu Gly
            740                 745                 750         
Leu Leu Cys Ala Ser Ser Pro Ala Ser Cys Cys His Val Ile
        755                 760                 765     


<210> 8449
<211> 3703
<212> PRT
<213> Homo sapiens

<400> 8449
Met Glu Gly Cys Asp Ser Pro Val Val Ser Gly Lys Asp Asn Gly Cys
 1               5                  10                  15      
Gly Ile Pro Gln His Gln Gln Trp Thr Glu Leu Asn Ser Thr His Leu
            20                  25                  30          
Pro Asp Lys Pro Ser Ser Met Glu Gln Ser Thr Gly Glu Ser His Gly
        35                  40                  45              
Pro Leu Asp Ser Leu Arg Ala Pro Phe Asn Glu Arg Leu Ala Glu Ser
    50                  55                  60                  
Thr Ala Ser Ala Gly Pro Pro Ala Glu Pro Ala Ser Lys Glu Val Thr
65                  70                  75                  80  
Cys Asn Glu Cys Ser Ala Ser Phe Ala Ser Leu Gln Thr Tyr Met Glu
                85                  90                  95      
His His Cys Pro Ser Ala Arg Pro Pro Pro Pro Leu Arg Glu Glu Ser
            100                 105                 110         
Ala Ser Asp Thr Gly Glu Glu Gly Asp Glu Glu Ser Asp Val Glu Asn
        115                 120                 125             
Leu Ala Gly Glu Ile Val Tyr Gln Pro Asp Gly Ser Ala Tyr Ile Val
    130                 135                 140                 
Glu Ser Leu Ser Gln Leu Thr Gln Gly Gly Gly Ala Cys Gly Ser Gly
145                 150                 155                 160 
Ser Gly Ser Gly Pro Leu Pro Ser Leu Phe Leu Asn Ser Leu Pro Gly
                165                 170                 175     
Ala Gly Gly Lys Gln Gly Asp Pro Ser Cys Ala Ala Pro Val Tyr Pro
            180                 185                 190         
Gln Ile Ile Asn Thr Phe His Ile Ala Ser Ser Phe Gly Lys Trp Phe
        195                 200                 205             
Glu Gly Pro Asp Gln Ala Phe Pro Asn Thr Ser Ala Leu Ala Gly Leu
    210                 215                 220                 
Ser Pro Val Leu His Ser Phe Arg Val Phe Asp Val Arg His Lys Ser
225                 230                 235                 240 
Asn Lys Asp Tyr Leu Asn Ser Asp Gly Ser Ala Lys Ser Ser Cys Val
                245                 250                 255     
Ser Lys Asp Val Pro Asn Asn Val Asp Leu Ser Lys Phe Asp Gly Phe
            260                 265                 270         
Val Leu Tyr Gly Lys Arg Lys Pro Ile Leu Met Cys Phe Leu Cys Lys
        275                 280                 285             
Leu Ser Phe Gly Tyr Val Arg Ser Phe Val Thr His Ala Val His Asp
    290                 295                 300                 
His Arg Met Thr Leu Ser Glu Asp Glu Arg Lys Ile Leu Ser Asn Lys
305                 310                 315                 320 
Asn Ile Ser Ala Ile Ile Gln Gly Ile Gly Lys Asp Lys Glu Pro Leu
                325                 330                 335     
Val Ser Phe Leu Glu Pro Lys Asn Lys Asn Phe Gln His Pro Leu Val
            340                 345                 350         
Ser Thr Ala Asn Leu Ile Gly Pro Gly His Ser Phe Tyr Gly Lys Phe
        355                 360                 365             
Ser Gly Ile Arg Met Glu Gly Glu Glu Ala Leu Pro Ala Gly Ser Ala
    370                 375                 380                 
Ala Gly Pro Glu Gln Pro Gln Ala Gly Leu Leu Thr Pro Ser Thr Leu
385                 390                 395                 400 
Leu Asn Leu Gly Gly Leu Thr Ser Ser Val Leu Lys Thr Pro Ile Thr
                405                 410                 415     
Ser Val Pro Leu Gly Ala Leu Ala Ser Ser Pro Thr Lys Ser Ser Glu
            420                 425                 430         
Gly Lys Asp Ser Gly Ala Ala Glu Gly Glu Lys Gln Glu Val Gly Asp
        435                 440                 445             
Gly Asp Cys Phe Ser Glu Lys Val Glu Pro Ala Glu Glu Glu Ala Glu
    450                 455                 460                 
Glu Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu Glu
465                 470                 475                 480 
Glu Glu Glu Glu Glu Glu Glu Asp Glu Gly Cys Lys Gly Leu Phe Pro
                485                 490                 495     
Ser Glu Leu Asp Glu Glu Leu Glu Asp Arg Pro His Glu Glu Pro Gly
            500                 505                 510         
Ala Ala Ala Gly Ser Ser Ser Lys Lys Asp Leu Ala Leu Ser Asn Gln
        515                 520                 525             
Ser Ile Ser Asn Ser Pro Leu Met Pro Asn Val Leu Gln Thr Leu Ser
    530                 535                 540                 
Arg Gly Thr Ala Ser Thr Ser Ser Asn Ser Ala Ser Ser Phe Val Val
545                 550                 555                 560 
Phe Asp Gly Ala Asn Arg Arg Asn Arg Leu Ser Phe Asn Ser Glu Gly
                565                 570                 575     
Val Arg Thr Asn Val Ala Glu Gly Gly Arg Arg Leu Asp Phe Ala Asp
            580                 585                 590         
Glu Ser Ala Asn Lys Asp Asn Ala Thr Ala Pro Glu Pro Asn Glu Ser
        595                 600                 605             
Thr Glu Gly Asp Asp Gly Gly Phe Val Pro His His Gln His Ala Gly
    610                 615                 620                 
Ser Leu Cys Glu Leu Gly Val Gly Glu Cys Pro Ser Gly Ser Gly Val
625                 630                 635                 640 
Glu Cys Pro Lys Cys Asp Thr Val Leu Gly Ser Ser Arg Ser Leu Gly
                645                 650                 655     
Gly His Met Thr Met Met His Ser Arg Asn Ser Cys Lys Thr Leu Lys
            660                 665                 670         
Cys Pro Lys Cys Asn Trp His Tyr Lys Tyr Gln Gln Thr Leu Glu Ala
        675                 680                 685             
His Met Lys Glu Lys His Pro Glu Pro Gly Gly Ser Cys Val Tyr Cys
    690                 695                 700                 
Lys Ser Gly Gln Pro His Pro Arg Leu Ala Arg Gly Glu Ser Tyr Thr
705                 710                 715                 720 
Cys Gly Tyr Lys Pro Phe Arg Cys Glu Val Cys Asn Tyr Ser Thr Thr
                725                 730                 735     
Thr Lys Gly Asn Leu Ser Ile His Met Gln Ser Asp Lys His Leu Asn
            740                 745                 750         
Asn Met Gln Asn Leu Gln Asn Gly Gly Gly Glu Gln Val Phe Ile His
        755                 760                 765             
Thr Ala Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
    770                 775                 780                 
Asn Ile Ser Ser Ser Cys Gly Ala Pro Ser Pro Thr Lys Pro Lys Thr
785                 790                 795                 800 
Lys Pro Thr Trp Arg Cys Glu Val Cys Asp Tyr Glu Thr Asn Val Ala
                805                 810                 815     
Arg Asn Leu Arg Ile His Met Thr Ser Glu Lys His Met His Asn Met
            820                 825                 830         
Met Leu Leu Gln Gln Asn Met Thr Gln Ile Gln His Asn His His Arg
        835                 840                 845             
Val Leu Gly Ser Leu Pro Ser Pro Ala Glu Ala Glu Leu Tyr Gln Tyr
    850                 855                 860                 
Tyr Leu Ala Gln Asn Met Asn Leu Pro Asn Leu Lys Met Asp Ser Ala
865                 870                 875                 880 
Ala Ser Asp Ala Gln Phe Met Met Ser Gly Phe Gln Leu Asp Pro Ala
                885                 890                 895     
Gly Pro Met Ala Ala Met Thr Pro Ala Leu Val Gly Gly Glu Ile Pro
            900                 905                 910         
Leu Asp Met Arg Leu Gly Gly Gly Gln Leu Val Ser Glu Glu Leu Met
        915                 920                 925             
Asn Leu Gly Glu Ser Phe Ile Gln Thr Asn Asp Pro Ser Leu Lys Leu
    930                 935                 940                 
Phe Gln Cys Ala Val Cys Asn Lys Phe Thr Thr Asp Asn Leu Asp Met
945                 950                 955                 960 
Leu Gly Leu His Met Asn Val Glu Arg Ser Leu Ser Glu Asp Glu Trp
                965                 970                 975     
Lys Ala Val Met Gly Asp Ser Tyr Gln Cys Lys Leu Cys Arg Tyr Asn
            980                 985                 990         
Thr Gln Leu Lys Ala Asn Phe Gln Leu His Cys Lys Thr Asp Lys His
        995                 1000                1005            
Val Gln Lys Tyr Gln Leu Val Ala His Ile Lys Glu Gly Gly Lys Ala
    1010                1015                1020                
Asn Glu Trp Arg Leu Lys Cys Val Ala Ile Gly Asn Pro Val His Leu
1025                1030                1035                1040
Lys Cys Asn Ala Cys Asp Tyr Tyr Thr Asn Ser Leu Glu Lys Leu Arg
                1045                1050                1055    
Leu His Thr Val Asn Ser Arg His Glu Ala Ser Leu Lys Leu Tyr Lys
            1060                1065                1070        
His Leu Gln Gln His Glu Ser Gly Val Glu Gly Glu Ser Cys Tyr Tyr
        1075                1080                1085            
His Cys Val Leu Cys Asn Tyr Ser Thr Lys Ala Lys Leu Asn Leu Ile
    1090                1095                1100                
Gln His Val Arg Ser Met Lys His Gln Arg Ser Glu Ser Leu Arg Lys
1105                1110                1115                1120
Leu Gln Arg Leu Gln Lys Gly Leu Pro Glu Glu Asp Glu Asp Leu Gly
                1125                1130                1135    
Gln Ile Phe Thr Ile Arg Arg Cys Pro Ser Thr Asp Pro Glu Glu Ala
            1140                1145                1150        
Ile Glu Asp Val Glu Gly Pro Ser Glu Thr Ala Ala Asp Pro Glu Glu
        1155                1160                1165            
Leu Ala Lys Asp Gln Glu Gly Gly Ala Ser Ser Ser Gln Ala Glu Lys
    1170                1175                1180                
Glu Leu Thr Asp Ser Pro Ala Thr Ser Lys Arg Ile Ser Phe Pro Gly
1185                1190                1195                1200
Ser Ser Glu Ser Pro Leu Ser Ser Lys Arg Pro Lys Thr Ala Glu Glu
                1205                1210                1215    
Ile Lys Pro Glu Gln Met Tyr Gln Cys Pro Tyr Cys Lys Tyr Ser Asn
            1220                1225                1230        
Ala Asp Val Asn Arg Leu Arg Val His Ala Met Thr Gln His Ser Val
        1235                1240                1245            
Gln Pro Met Leu Arg Cys Pro Leu Cys Gln Asp Met Leu Asn Asn Lys
    1250                1255                1260                
Ile His Leu Gln Leu His Leu Thr His Leu His Ser Val Ala Pro Asp
1265                1270                1275                1280
Cys Val Glu Lys Leu Ile Met Thr Val Thr Thr Pro Glu Met Val Met
                1285                1290                1295    
Pro Ser Ser Met Phe Leu Pro Ala Ala Val Pro Asp Arg Asp Gly Asn
            1300                1305                1310        
Ser Asn Leu Glu Glu Ala Gly Lys Gln Pro Glu Thr Ser Glu Asp Leu
        1315                1320                1325            
Gly Lys Asn Ile Leu Pro Ser Ala Ser Thr Glu Gln Ser Gly Asp Leu
    1330                1335                1340                
Lys Pro Ser Pro Ala Asp Pro Gly Ser Val Arg Glu Asp Ser Gly Phe
1345                1350                1355                1360
Ile Cys Trp Lys Lys Gly Cys Asn Gln Val Phe Lys Thr Ser Ala Ala
                1365                1370                1375    
Leu Gln Thr His Phe Asn Glu Val His Ala Lys Arg Pro Gln Leu Pro
            1380                1385                1390        
Val Ser Asp Arg His Val Tyr Lys Tyr Arg Cys Asn Gln Cys Ser Leu
        1395                1400                1405            
Ala Phe Lys Thr Ile Glu Lys Leu Gln Leu His Ser Gln Tyr His Val
    1410                1415                1420                
Ile Arg Ala Ala Thr Met Cys Cys Leu Cys Gln Arg Ser Phe Arg Thr
1425                1430                1435                1440
Phe Gln Ala Leu Lys Lys His Leu Glu Thr Ser His Leu Glu Leu Ser
                1445                1450                1455    
Glu Ala Asp Ile Gln Gln Leu Tyr Gly Gly Leu Leu Ala Asn Gly Asp
            1460                1465                1470        
Leu Leu Ala Met Gly Asp Pro Thr Leu Ala Glu Asp His Thr Ile Ile
        1475                1480                1485            
Val Glu Glu Asp Lys Glu Glu Glu Ser Asp Leu Glu Asp Lys Gln Ser
    1490                1495                1500                
Pro Thr Gly Ser Asp Ser Gly Ser Val Gln Glu Asp Ser Gly Ser Glu
1505                1510                1515                1520
Pro Lys Arg Ala Leu Pro Phe Arg Lys Gly Pro Asn Phe Thr Met Glu
                1525                1530                1535    
Lys Phe Leu Asp Pro Ser Arg Pro Tyr Lys Cys Thr Val Cys Lys Glu
            1540                1545                1550        
Ser Phe Thr Gln Lys Asn Ile Leu Leu Val His Tyr Asn Ser Val Ser
        1555                1560                1565            
His Leu His Lys Leu Lys Arg Ala Leu Gln Glu Ser Ala Thr Gly Gln
    1570                1575                1580                
Pro Glu Pro Thr Ser Ser Pro Asp Asn Lys Pro Phe Lys Cys Asn Thr
1585                1590                1595                1600
Cys Asn Val Ala Tyr Ser Gln Ser Ser Thr Leu Glu Ile His Met Arg
                1605                1610                1615    
Ser Val Leu His Gln Thr Lys Ala Arg Ala Ala Lys Leu Glu Ala Ala
            1620                1625                1630        
Ser Gly Ser Ser Asn Gly Thr Gly Asn Ser Ser Ser Ile Ser Leu Ser
        1635                1640                1645            
Ser Ser Thr Pro Ser Pro Val Ser Thr Ser Gly Ser Asn Thr Phe Thr
    1650                1655                1660                
Thr Ser Asn Pro Ser Ser Ala Gly Ile Ala Pro Ser Ser Asn Leu Leu
1665                1670                1675                1680
Ser Gln Val Pro Thr Glu Ser Val Gly Met Pro Pro Leu Gly Asn Pro
                1685                1690                1695    
Ile Gly Ala Asn Ile Ala Ser Pro Ser Glu Pro Lys Glu Ala Asn Arg
            1700                1705                1710        
Lys Lys Leu Ala Asp Met Ile Ala Ser Arg Gln Gln Gln Gln Gln Gln
        1715                1720                1725            
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Gln Thr
    1730                1735                1740                
Leu Ala Gln Ala Gln Ala Gln Val Gln Ala His Leu Gln Gln Glu Leu
1745                1750                1755                1760
Gln Gln Gln Ala Ala Leu Ile Gln Ser Gln Leu Phe Asn Pro Thr Leu
                1765                1770                1775    
Leu Pro His Phe Pro Met Thr Thr Glu Thr Leu Leu Gln Leu Gln Gln
            1780                1785                1790        
Gln Gln His Leu Leu Phe Pro Phe Tyr Ile Pro Ser Ala Glu Phe Gln
        1795                1800                1805            
Leu Asn Pro Glu Val Ser Leu Pro Val Thr Ser Gly Ala Leu Thr Leu
    1810                1815                1820                
Thr Gly Thr Gly Pro Gly Leu Leu Glu Asp Leu Lys Ala Gln Val Gln
1825                1830                1835                1840
Val Pro Gln Gln Ser His Gln Gln Ile Leu Pro Gln Gln Gln Gln Asn
                1845                1850                1855    
Gln Leu Ser Ile Ala Gln Ser His Ser Ala Leu Leu Gln Pro Ser Gln
            1860                1865                1870        
His Pro Glu Lys Lys Asn Lys Leu Val Ile Lys Glu Lys Glu Lys Glu
        1875                1880                1885            
Ser Gln Arg Glu Arg Asp Ser Ala Glu Gly Gly Glu Gly Asn Thr Gly
    1890                1895                1900                
Pro Lys Glu Thr Leu Pro Asp Ala Leu Lys Ala Lys Glu Lys Lys Glu
1905                1910                1915                1920
Leu Ala Pro Gly Gly Gly Ser Glu Pro Ser Met Leu Pro Pro Arg Ile
                1925                1930                1935    
Ala Ser Asp Ala Arg Gly Asn Ala Thr Lys Ala Leu Leu Glu Asn Phe
            1940                1945                1950        
Gly Phe Glu Leu Val Ile Gln Tyr Asn Glu Asn Lys Gln Lys Val Gln
        1955                1960                1965            
Lys Lys Asn Gly Lys Thr Asp Gln Gly Glu Asn Leu Glu Lys Leu Glu
    1970                1975                1980                
Cys Asp Ser Cys Gly Lys Leu Phe Ser Asn Ile Leu Ile Leu Lys Ser
1985                1990                1995                2000
His Gln Glu His Val His Gln Asn Tyr Phe Pro Phe Lys Gln Leu Glu
                2005                2010                2015    
Arg Phe Ala Lys Gln Tyr Arg Asp His Tyr Asp Lys Leu Tyr Pro Leu
            2020                2025                2030        
Arg Pro Gln Thr Pro Glu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
        2035                2040                2045            
Pro Pro Leu Pro Ala Ala Pro Pro Gln Pro Ala Ser Thr Pro Ala Ile
    2050                2055                2060                
Pro Ala Ser Ala Pro Pro Ile Thr Ser Pro Thr Ile Ala Pro Ala Gln
2065                2070                2075                2080
Pro Ser Val Pro Leu Thr Gln Leu Ser Met Pro Met Glu Leu Pro Ile
                2085                2090                2095    
Phe Ser Pro Leu Met Met Gln Thr Met Pro Leu Gln Thr Leu Pro Ala
            2100                2105                2110        
Gln Leu Pro Pro Gln Leu Gly Pro Val Glu Pro Leu Pro Ala Asp Leu
        2115                2120                2125            
Ala Gln Leu Tyr Gln His Gln Leu Asn Pro Thr Leu Leu Gln Gln Gln
    2130                2135                2140                
Asn Lys Arg Pro Arg Thr Arg Ile Thr Asp Asp Gln Leu Arg Val Leu
2145                2150                2155                2160
Arg Gln Tyr Phe Asp Ile Asn Asn Ser Pro Ser Glu Glu Gln Ile Lys
                2165                2170                2175    
Glu Met Ala Asp Lys Ser Gly Leu Pro Gln Lys Val Ile Lys His Trp
            2180                2185                2190        
Phe Arg Asn Thr Leu Phe Lys Glu Arg Gln Arg Asn Lys Asp Ser Pro
        2195                2200                2205            
Tyr Asn Phe Ser Asn Pro Pro Ile Thr Ser Leu Glu Glu Leu Lys Ile
    2210                2215                2220                
Asp Ser Arg Pro Pro Ser Pro Glu Pro Pro Lys Gln Glu Tyr Trp Gly
2225                2230                2235                2240
Ser Lys Arg Ser Ser Arg Thr Arg Phe Thr Asp Tyr Gln Leu Arg Val
                2245                2250                2255    
Leu Gln Asp Phe Phe Asp Ala Asn Ala Tyr Pro Lys Asp Asp Glu Phe
            2260                2265                2270        
Glu Gln Leu Ser Asn Leu Leu Asn Leu Pro Thr Arg Val Ile Val Val
        2275                2280                2285            
Trp Phe Gln Asn Ala Arg Gln Lys Ala Arg Lys Asn Tyr Glu Asn Gln
    2290                2295                2300                
Gly Glu Gly Lys Asp Gly Glu Arg Arg Glu Leu Thr Asn Asp Arg Tyr
2305                2310                2315                2320
Ile Arg Thr Ser Asn Leu Asn Tyr Gln Cys Lys Lys Cys Ser Leu Val
                2325                2330                2335    
Phe Gln Arg Ile Phe Asp Leu Ile Lys His Gln Lys Lys Leu Cys Tyr
            2340                2345                2350        
Lys Asp Glu Asp Glu Glu Gly Gln Asp Asp Ser Gln Asn Glu Asp Ser
        2355                2360                2365            
Met Asp Ala Met Glu Ile Leu Thr Pro Thr Ser Ser Ser Cys Ser Thr
    2370                2375                2380                
Pro Met Pro Ser Gln Ala Tyr Ser Ala Pro Ala Pro Ser Ala Asn Asn
2385                2390                2395                2400
Thr Ala Ser Ser Ala Phe Leu Gln Leu Thr Ala Glu Ala Glu Glu Leu
                2405                2410                2415    
Ala Thr Phe Asn Ser Lys Thr Glu Ala Gly Asp Glu Lys Pro Lys Leu
            2420                2425                2430        
Ala Glu Ala Pro Ser Ala Gln Pro Asn Gln Thr Gln Glu Lys Gln Gly
        2435                2440                2445            
Gln Pro Lys Pro Glu Leu Gln Gln Gln Glu Gln Pro Glu Gln Lys Thr
    2450                2455                2460                
Asn Thr Pro Gln Gln Lys Leu Pro Gln Leu Val Ser Leu Pro Ser Leu
2465                2470                2475                2480
Pro Gln Pro Pro Pro Gln Ala Pro Pro Pro Gln Cys Pro Leu Pro Gln
                2485                2490                2495    
Ser Ser Pro Ser Pro Ser Gln Leu Ser His Leu Pro Leu Lys Pro Leu
            2500                2505                2510        
His Thr Ser Thr Pro Gln Gln Leu Ala Asn Leu Pro Pro Gln Leu Ile
        2515                2520                2525            
Pro Tyr Gln Cys Asp Gln Cys Lys Leu Ala Phe Pro Ser Phe Glu His
    2530                2535                2540                
Trp Gln Glu His Gln Gln Leu His Phe Leu Ser Ala Gln Asn Gln Phe
2545                2550                2555                2560
Ile His Pro Gln Phe Leu Asp Arg Ser Leu Asp Met Pro Phe Met Leu
                2565                2570                2575    
Phe Asp Pro Ser Asn Pro Leu Leu Ala Ser Gln Leu Leu Ser Gly Ala
            2580                2585                2590        
Ile Pro Gln Ile Pro Ala Ser Ser Ala Thr Ser Pro Ser Thr Pro Thr
        2595                2600                2605            
Ser Thr Met Asn Thr Leu Lys Arg Lys Leu Glu Glu Lys Ala Ser Ala
    2610                2615                2620                
Ser Pro Gly Glu Asn Asp Ser Gly Thr Gly Gly Glu Glu Pro Gln Arg
2625                2630                2635                2640
Asp Lys Arg Leu Arg Thr Thr Ile Thr Pro Glu Gln Leu Glu Ile Leu
                2645                2650                2655    
Tyr Gln Lys Tyr Leu Leu Asp Ser Asn Pro Thr Arg Lys Met Leu Asp
            2660                2665                2670        
His Ile Ala His Glu Val Gly Leu Lys Lys Arg Val Val Gln Val Trp
        2675                2680                2685            
Phe Gln Asn Thr Arg Ala Arg Glu Arg Lys Gly Gln Phe Arg Ala Val
    2690                2695                2700                
Gly Pro Ala Gln Ala His Arg Arg Cys Pro Phe Cys Arg Ala Leu Phe
2705                2710                2715                2720
Lys Ala Lys Thr Ala Leu Glu Ala His Ile Arg Ser Arg His Trp His
                2725                2730                2735    
Glu Ala Lys Arg Ala Gly Tyr Asn Leu Thr Leu Ser Ala Met Leu Leu
            2740                2745                2750        
Asp Cys Asp Gly Gly Leu Gln Met Lys Gly Asp Ile Phe Asp Gly Thr
        2755                2760                2765            
Ser Phe Ser His Leu Pro Pro Ser Ser Ser Asp Gly Gln Gly Val Pro
    2770                2775                2780                
Leu Ser Pro Val Ser Lys Thr Met Glu Leu Ser Pro Arg Thr Leu Leu
2785                2790                2795                2800
Ser Pro Ser Ser Ile Lys Val Glu Gly Ile Glu Asp Phe Glu Ser Pro
                2805                2810                2815    
Ser Met Ser Ser Val Asn Leu Asn Phe Asp Gln Thr Lys Leu Asp Asn
            2820                2825                2830        
Asp Asp Cys Ser Ser Val Asn Thr Ala Ile Thr Asp Thr Thr Thr Gly
        2835                2840                2845            
Asp Glu Gly Asn Ala Asp Asn Asp Ser Ala Thr Gly Ile Ala Thr Glu
    2850                2855                2860                
Thr Lys Ser Ser Ser Ala Pro Asn Glu Gly Leu Thr Lys Ala Ala Met
2865                2870                2875                2880
Met Ala Met Ser Glu Tyr Glu Asp Arg Leu Ser Ser Gly Leu Val Ser
                2885                2890                2895    
Pro Ala Pro Ser Phe Tyr Ser Lys Glu Tyr Asp Asn Glu Gly Thr Val
            2900                2905                2910        
Asp Tyr Ser Glu Thr Ser Ser Leu Ala Asp Pro Cys Ser Pro Ser Pro
        2915                2920                2925            
Gly Ala Ser Gly Ser Ala Gly Lys Ser Gly Asp Ser Gly Asp Arg Pro
    2930                2935                2940                
Gly Gln Lys Arg Phe Arg Thr Gln Met Thr Asn Leu Gln Leu Lys Val
2945                2950                2955                2960
Leu Lys Ser Cys Phe Asn Asp Tyr Arg Thr Pro Thr Met Leu Glu Cys
                2965                2970                2975    
Glu Val Leu Gly Asn Asp Ile Gly Leu Pro Lys Arg Val Val Gln Val
            2980                2985                2990        
Trp Phe Gln Asn Ala Arg Ala Lys Glu Lys Lys Ser Lys Leu Ser Met
        2995                3000                3005            
Ala Lys His Phe Gly Ile Asn Gln Thr Ser Tyr Glu Gly Pro Lys Thr
    3010                3015                3020                
Glu Cys Thr Leu Cys Gly Ile Lys Tyr Ser Ala Arg Leu Ser Val Arg
3025                3030                3035                3040
Asp His Ile Phe Ser Gln Gln His Ile Ser Lys Val Lys Asp Thr Ile
                3045                3050                3055    
Gly Ser Gln Leu Asp Lys Glu Lys Glu Tyr Phe Asp Pro Ala Thr Val
            3060                3065                3070        
Arg Gln Leu Met Ala Gln Gln Glu Leu Asp Arg Ile Lys Lys Ala Asn
        3075                3080                3085            
Glu Val Leu Gly Leu Ala Ala Gln Gln Gln Gly Met Phe Asp Asn Thr
    3090                3095                3100                
Pro Leu Gln Ala Leu Asn Leu Pro Thr Ala Tyr Pro Ala Leu Gln Gly
3105                3110                3115                3120
Ile Pro Pro Val Leu Leu Pro Gly Leu Asn Ser Pro Ser Leu Pro Gly
                3125                3130                3135    
Phe Thr Pro Ser Asn Thr Ala Leu Thr Ser Pro Lys Pro Asn Leu Met
            3140                3145                3150        
Gly Leu Pro Ser Thr Thr Val Pro Ser Pro Gly Leu Pro Thr Ser Gly
        3155                3160                3165            
Leu Pro Asn Lys Pro Ser Ser Ala Ser Leu Ser Ser Pro Thr Pro Ala
    3170                3175                3180                
Gln Ala Thr Met Ala Met Gly Pro Gln Gln Pro Pro Gln Gln Gln Gln
3185                3190                3195                3200
Gln Gln Gln Gln Pro Gln Val Gln Gln Pro Pro Pro Pro Pro Ala Ala
                3205                3210                3215    
Gln Pro Pro Pro Thr Pro Gln Leu Pro Leu Gln Gln Gln Gln Gln Arg
            3220                3225                3230        
Lys Asp Lys Asp Ser Glu Lys Val Lys Glu Lys Glu Lys Ala His Lys
        3235                3240                3245            
Gly Lys Gly Glu Pro Leu Pro Val Pro Lys Lys Glu Lys Gly Glu Ala
    3250                3255                3260                
Pro Thr Ala Thr Ala Ala Thr Ile Ser Ala Pro Leu Pro Thr Met Glu
3265                3270                3275                3280
Tyr Ala Val Asp Pro Ala Gln Leu Gln Ala Leu Gln Ala Ala Leu Thr
                3285                3290                3295    
Ser Asp Pro Thr Ala Leu Leu Thr Ser Gln Phe Leu Pro Tyr Phe Val
            3300                3305                3310        
Pro Gly Phe Ser Pro Tyr Tyr Ala Pro Gln Ile Pro Gly Ala Leu Gln
        3315                3320                3325            
Ser Gly Tyr Leu Gln Pro Met Tyr Gly Met Glu Gly Leu Phe Pro Tyr
    3330                3335                3340                
Ser Pro Ala Leu Ser Gln Ala Leu Met Gly Leu Ser Pro Gly Ser Leu
3345                3350                3355                3360
Leu Gln Gln Tyr Gln Gln Tyr Gln Gln Ser Leu Gln Glu Ala Ile Gln
                3365                3370                3375    
Gln Gln Gln Gln Arg Gln Leu Gln Gln Gln Gln Gln Gln Lys Val Gln
            3380                3385                3390        
Gln Gln Gln Pro Lys Ala Ser Gln Thr Pro Val Pro Pro Gly Ala Pro
        3395                3400                3405            
Ser Pro Asp Lys Asp Pro Ala Lys Glu Ser Pro Lys Pro Glu Glu Gln
    3410                3415                3420                
Lys Asn Thr Pro Arg Glu Val Ser Pro Leu Leu Pro Lys Leu Pro Glu
3425                3430                3435                3440
Glu Pro Glu Ala Glu Ser Lys Ser Ala Asp Ser Leu Tyr Asp Pro Phe
                3445                3450                3455    
Ile Val Pro Lys Val Gln Tyr Lys Leu Val Cys Arg Lys Cys Gln Ala
            3460                3465                3470        
Gly Phe Ser Asp Glu Glu Ala Ala Arg Ser His Leu Lys Ser Leu Cys
        3475                3480                3485            
Phe Phe Gly Gln Ser Val Val Asn Leu Gln Glu Met Val Leu His Val
    3490                3495                3500                
Pro Thr Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly
3505                3510                3515                3520
Gly Gly Gly Gly Gly Gly Gly Ser Tyr His Cys Leu Ala Cys Glu Ser
                3525                3530                3535    
Ala Leu Cys Gly Glu Glu Ala Leu Ser Gln His Leu Glu Ser Ala Leu
            3540                3545                3550        
His Lys His Arg Thr Ile Thr Arg Ala Ala Arg Asn Ala Lys Glu His
        3555                3560                3565            
Pro Ser Leu Leu Pro His Ser Ala Cys Phe Pro Asp Pro Ser Thr Ala
    3570                3575                3580                
Ser Thr Ser Gln Ser Ala Ala His Ser Asn Asp Ser Pro Pro Pro Pro
3585                3590                3595                3600
Ser Ala Ala Ala Pro Ser Ser Ala Ser Pro His Ala Ser Arg Lys Ser
                3605                3610                3615    
Trp Pro Gln Val Val Ser Arg Ala Ser Ala Ala Lys Pro Pro Ser Phe
            3620                3625                3630        
Pro Pro Leu Ser Ser Ser Ser Thr Val Thr Ser Ser Ser Cys Ser Thr
        3635                3640                3645            
Ser Gly Val Gln Pro Ser Met Pro Thr Asp Asp Tyr Ser Glu Glu Ser
    3650                3655                3660                
Asp Thr Asp Leu Ser Gln Lys Ser Asp Gly Pro Ala Ser Pro Val Glu
3665                3670                3675                3680
Gly Pro Lys Asp Pro Ser Cys Pro Lys Asp Ser Gly Leu Thr Ser Val
                3685                3690                3695    
Gly Thr Asp Thr Phe Arg Leu
            3700            


<210> 8450
<211> 2789
<212> PRT
<213> Homo sapiens

<400> 8450
Met Arg Leu Gly Gly Gly Gln Leu Val Ser Glu Glu Leu Met Asn Leu
 1               5                  10                  15      
Gly Glu Ser Phe Ile Gln Thr Asn Asp Pro Ser Leu Lys Leu Phe Gln
            20                  25                  30          
Cys Ala Val Cys Asn Lys Phe Thr Thr Asp Asn Leu Asp Met Leu Gly
        35                  40                  45              
Leu His Met Asn Val Glu Arg Ser Leu Ser Glu Asp Glu Trp Lys Ala
    50                  55                  60                  
Val Met Gly Asp Ser Tyr Gln Cys Lys Leu Cys Arg Tyr Asn Thr Gln
65                  70                  75                  80  
Leu Lys Ala Asn Phe Gln Leu His Cys Lys Thr Asp Lys His Val Gln
                85                  90                  95      
Lys Tyr Gln Leu Val Ala His Ile Lys Glu Gly Gly Lys Ala Asn Glu
            100                 105                 110         
Trp Arg Leu Lys Cys Val Ala Ile Gly Asn Pro Val His Leu Lys Cys
        115                 120                 125             
Asn Ala Cys Asp Tyr Tyr Thr Asn Ser Leu Glu Lys Leu Arg Leu His
    130                 135                 140                 
Thr Val Asn Ser Arg His Glu Ala Ser Leu Lys Leu Tyr Lys His Leu
145                 150                 155                 160 
Gln Gln His Glu Ser Gly Val Glu Gly Glu Ser Cys Tyr Tyr His Cys
                165                 170                 175     
Val Leu Cys Asn Tyr Ser Thr Lys Ala Lys Leu Asn Leu Ile Gln His
            180                 185                 190         
Val Arg Ser Met Lys His Gln Arg Ser Glu Ser Leu Arg Lys Leu Gln
        195                 200                 205             
Arg Leu Gln Lys Gly Leu Pro Glu Glu Asp Glu Asp Leu Gly Gln Ile
    210                 215                 220                 
Phe Thr Ile Arg Arg Cys Pro Ser Thr Asp Pro Glu Glu Ala Ile Glu
225                 230                 235                 240 
Asp Val Glu Gly Pro Ser Glu Thr Ala Ala Asp Pro Glu Glu Leu Ala
                245                 250                 255     
Lys Asp Gln Glu Gly Gly Ala Ser Ser Ser Gln Ala Glu Lys Glu Leu
            260                 265                 270         
Thr Asp Ser Pro Ala Thr Ser Lys Arg Ile Ser Phe Pro Gly Ser Ser
        275                 280                 285             
Glu Ser Pro Leu Ser Ser Lys Arg Pro Lys Thr Ala Glu Glu Ile Lys
    290                 295                 300                 
Pro Glu Gln Met Tyr Gln Cys Pro Tyr Cys Lys Tyr Ser Asn Ala Asp
305                 310                 315                 320 
Val Asn Arg Leu Arg Val His Ala Met Thr Gln His Ser Val Gln Pro
                325                 330                 335     
Met Leu Arg Cys Pro Leu Cys Gln Asp Met Leu Asn Asn Lys Ile His
            340                 345                 350         
Leu Gln Leu His Leu Thr His Leu His Ser Val Ala Pro Asp Cys Val
        355                 360                 365             
Glu Lys Leu Ile Met Thr Val Thr Thr Pro Glu Met Val Met Pro Ser
    370                 375                 380                 
Ser Met Phe Leu Pro Ala Ala Val Pro Asp Arg Asp Gly Asn Ser Asn
385                 390                 395                 400 
Leu Glu Glu Ala Gly Lys Gln Pro Glu Thr Ser Glu Asp Leu Gly Lys
                405                 410                 415     
Asn Ile Leu Pro Ser Ala Ser Thr Glu Gln Ser Gly Asp Leu Lys Pro
            420                 425                 430         
Ser Pro Ala Asp Pro Gly Ser Val Arg Glu Asp Ser Gly Phe Ile Cys
        435                 440                 445             
Trp Lys Lys Gly Cys Asn Gln Val Phe Lys Thr Ser Ala Ala Leu Gln
    450                 455                 460                 
Thr His Phe Asn Glu Val His Ala Lys Arg Pro Gln Leu Pro Val Ser
465                 470                 475                 480 
Asp Arg His Val Tyr Lys Tyr Arg Cys Asn Gln Cys Ser Leu Ala Phe
                485                 490                 495     
Lys Thr Ile Glu Lys Leu Gln Leu His Ser Gln Tyr His Val Ile Arg
            500                 505                 510         
Ala Ala Thr Met Cys Cys Leu Cys Gln Arg Ser Phe Arg Thr Phe Gln
        515                 520                 525             
Ala Leu Lys Lys His Leu Glu Thr Ser His Leu Glu Leu Ser Glu Ala
    530                 535                 540                 
Asp Ile Gln Gln Leu Tyr Gly Gly Leu Leu Ala Asn Gly Asp Leu Leu
545                 550                 555                 560 
Ala Met Gly Asp Pro Thr Leu Ala Glu Asp His Thr Ile Ile Val Glu
                565                 570                 575     
Glu Asp Lys Glu Glu Glu Ser Asp Leu Glu Asp Lys Gln Ser Pro Thr
            580                 585                 590         
Gly Ser Asp Ser Gly Ser Val Gln Glu Asp Ser Gly Ser Glu Pro Lys
        595                 600                 605             
Arg Ala Leu Pro Phe Arg Lys Gly Pro Asn Phe Thr Met Glu Lys Phe
    610                 615                 620                 
Leu Asp Pro Ser Arg Pro Tyr Lys Cys Thr Val Cys Lys Glu Ser Phe
625                 630                 635                 640 
Thr Gln Lys Asn Ile Leu Leu Val His Tyr Asn Ser Val Ser His Leu
                645                 650                 655     
His Lys Leu Lys Arg Ala Leu Gln Glu Ser Ala Thr Gly Gln Pro Glu
            660                 665                 670         
Pro Thr Ser Ser Pro Asp Asn Lys Pro Phe Lys Cys Asn Thr Cys Asn
        675                 680                 685             
Val Ala Tyr Ser Gln Ser Ser Thr Leu Glu Ile His Met Arg Ser Val
    690                 695                 700                 
Leu His Gln Thr Lys Ala Arg Ala Ala Lys Leu Glu Ala Ala Ser Gly
705                 710                 715                 720 
Ser Ser Asn Gly Thr Gly Asn Ser Ser Ser Ile Ser Leu Ser Ser Ser
                725                 730                 735     
Thr Pro Ser Pro Val Ser Thr Ser Gly Ser Asn Thr Phe Thr Thr Ser
            740                 745                 750         
Asn Pro Ser Ser Ala Gly Ile Ala Pro Ser Ser Asn Leu Leu Ser Gln
        755                 760                 765             
Val Pro Thr Glu Ser Val Gly Met Pro Pro Leu Gly Asn Pro Ile Gly
    770                 775                 780                 
Ala Asn Ile Ala Ser Pro Ser Glu Pro Lys Glu Ala Asn Arg Lys Lys
785                 790                 795                 800 
Leu Ala Asp Met Ile Ala Ser Arg Gln Gln Gln Gln Gln Gln Gln Gln
                805                 810                 815     
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Gln Thr Leu Ala
            820                 825                 830         
Gln Ala Gln Ala Gln Val Gln Ala His Leu Gln Gln Glu Leu Gln Gln
        835                 840                 845             
Gln Ala Ala Leu Ile Gln Ser Gln Leu Phe Asn Pro Thr Leu Leu Pro
    850                 855                 860                 
His Phe Pro Met Thr Thr Glu Thr Leu Leu Gln Leu Gln Gln Gln Gln
865                 870                 875                 880 
His Leu Leu Phe Pro Phe Tyr Ile Pro Ser Ala Glu Phe Gln Leu Asn
                885                 890                 895     
Pro Glu Val Ser Leu Pro Val Thr Ser Gly Ala Leu Thr Leu Thr Gly
            900                 905                 910         
Thr Gly Pro Gly Leu Leu Glu Asp Leu Lys Ala Gln Val Gln Val Pro
        915                 920                 925             
Gln Gln Ser His Gln Gln Ile Leu Pro Gln Gln Gln Gln Asn Gln Leu
    930                 935                 940                 
Ser Ile Ala Gln Ser His Ser Ala Leu Leu Gln Pro Ser Gln His Pro
945                 950                 955                 960 
Glu Lys Lys Asn Lys Leu Val Ile Lys Glu Lys Glu Lys Glu Ser Gln
                965                 970                 975     
Arg Glu Arg Asp Ser Ala Glu Gly Gly Glu Gly Asn Thr Gly Pro Lys
            980                 985                 990         
Glu Thr Leu Pro Asp Ala Leu Lys Ala Lys Glu Lys Lys Glu Leu Ala
        995                 1000                1005            
Pro Gly Gly Gly Ser Glu Pro Ser Met Leu Pro Pro Arg Ile Ala Ser
    1010                1015                1020                
Asp Ala Arg Gly Asn Ala Thr Lys Ala Leu Leu Glu Asn Phe Gly Phe
1025                1030                1035                1040
Glu Leu Val Ile Gln Tyr Asn Glu Asn Lys Gln Lys Val Gln Lys Lys
                1045                1050                1055    
Asn Gly Lys Thr Asp Gln Gly Glu Asn Leu Glu Lys Leu Glu Cys Asp
            1060                1065                1070        
Ser Cys Gly Lys Leu Phe Ser Asn Ile Leu Ile Leu Lys Ser His Gln
        1075                1080                1085            
Glu His Val His Gln Asn Tyr Phe Pro Phe Lys Gln Leu Glu Arg Phe
    1090                1095                1100                
Ala Lys Gln Tyr Arg Asp His Tyr Asp Lys Leu Tyr Pro Leu Arg Pro
1105                1110                1115                1120
Gln Thr Pro Glu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
                1125                1130                1135    
Leu Pro Ala Ala Pro Pro Gln Pro Ala Ser Thr Pro Ala Ile Pro Ala
            1140                1145                1150        
Ser Ala Pro Pro Ile Thr Ser Pro Thr Ile Ala Pro Ala Gln Pro Ser
        1155                1160                1165            
Val Pro Leu Thr Gln Leu Ser Met Pro Met Glu Leu Pro Ile Phe Ser
    1170                1175                1180                
Pro Leu Met Met Gln Thr Met Pro Leu Gln Thr Leu Pro Ala Gln Leu
1185                1190                1195                1200
Pro Pro Gln Leu Gly Pro Val Glu Pro Leu Pro Ala Asp Leu Ala Gln
                1205                1210                1215    
Leu Tyr Gln His Gln Leu Asn Pro Thr Leu Leu Gln Gln Gln Asn Lys
            1220                1225                1230        
Arg Pro Arg Thr Arg Ile Thr Asp Asp Gln Leu Arg Val Leu Arg Gln
        1235                1240                1245            
Tyr Phe Asp Ile Asn Asn Ser Pro Ser Glu Glu Gln Ile Lys Glu Met
    1250                1255                1260                
Ala Asp Lys Ser Gly Leu Pro Gln Lys Val Ile Lys His Trp Phe Arg
1265                1270                1275                1280
Asn Thr Leu Phe Lys Glu Arg Gln Arg Asn Lys Asp Ser Pro Tyr Asn
                1285                1290                1295    
Phe Ser Asn Pro Pro Ile Thr Ser Leu Glu Glu Leu Lys Ile Asp Ser
            1300                1305                1310        
Arg Pro Pro Ser Pro Glu Pro Pro Lys Gln Glu Tyr Trp Gly Ser Lys
        1315                1320                1325            
Arg Ser Ser Arg Thr Arg Phe Thr Asp Tyr Gln Leu Arg Val Leu Gln
    1330                1335                1340                
Asp Phe Phe Asp Ala Asn Ala Tyr Pro Lys Asp Asp Glu Phe Glu Gln
1345                1350                1355                1360
Leu Ser Asn Leu Leu Asn Leu Pro Thr Arg Val Ile Val Val Trp Phe
                1365                1370                1375    
Gln Asn Ala Arg Gln Lys Ala Arg Lys Asn Tyr Glu Asn Gln Gly Glu
            1380                1385                1390        
Gly Lys Asp Gly Glu Arg Arg Glu Leu Thr Asn Asp Arg Tyr Ile Arg
        1395                1400                1405            
Thr Ser Asn Leu Asn Tyr Gln Cys Lys Lys Cys Ser Leu Val Phe Gln
    1410                1415                1420                
Arg Ile Phe Asp Leu Ile Lys His Gln Lys Lys Leu Cys Tyr Lys Asp
1425                1430                1435                1440
Glu Asp Glu Glu Gly Gln Asp Asp Ser Gln Asn Glu Asp Ser Met Asp
                1445                1450                1455    
Ala Met Glu Ile Leu Thr Pro Thr Ser Ser Ser Cys Ser Thr Pro Met
            1460                1465                1470        
Pro Ser Gln Ala Tyr Ser Ala Pro Ala Pro Ser Ala Asn Asn Thr Ala
        1475                1480                1485            
Ser Ser Ala Phe Leu Gln Leu Thr Ala Glu Ala Glu Glu Leu Ala Thr
    1490                1495                1500                
Phe Asn Ser Lys Thr Glu Ala Gly Asp Glu Lys Pro Lys Leu Ala Glu
1505                1510                1515                1520
Ala Pro Ser Ala Gln Pro Asn Gln Thr Gln Glu Lys Gln Gly Gln Pro
                1525                1530                1535    
Lys Pro Glu Leu Gln Gln Gln Glu Gln Pro Glu Gln Lys Thr Asn Thr
            1540                1545                1550        
Pro Gln Gln Lys Leu Pro Gln Leu Val Ser Leu Pro Ser Leu Pro Gln
        1555                1560                1565            
Pro Pro Pro Gln Ala Pro Pro Pro Gln Cys Pro Leu Pro Gln Ser Ser
    1570                1575                1580                
Pro Ser Pro Ser Gln Leu Ser His Leu Pro Leu Lys Pro Leu His Thr
1585                1590                1595                1600
Ser Thr Pro Gln Gln Leu Ala Asn Leu Pro Pro Gln Leu Ile Pro Tyr
                1605                1610                1615    
Gln Cys Asp Gln Cys Lys Leu Ala Phe Pro Ser Phe Glu His Trp Gln
            1620                1625                1630        
Glu His Gln Gln Leu His Phe Leu Ser Ala Gln Asn Gln Phe Ile His
        1635                1640                1645            
Pro Gln Phe Leu Asp Arg Ser Leu Asp Met Pro Phe Met Leu Phe Asp
    1650                1655                1660                
Pro Ser Asn Pro Leu Leu Ala Ser Gln Leu Leu Ser Gly Ala Ile Pro
1665                1670                1675                1680
Gln Ile Pro Ala Ser Ser Ala Thr Ser Pro Ser Thr Pro Thr Ser Thr
                1685                1690                1695    
Met Asn Thr Leu Lys Arg Lys Leu Glu Glu Lys Ala Ser Ala Ser Pro
            1700                1705                1710        
Gly Glu Asn Asp Ser Gly Thr Gly Gly Glu Glu Pro Gln Arg Asp Lys
        1715                1720                1725            
Arg Leu Arg Thr Thr Ile Thr Pro Glu Gln Leu Glu Ile Leu Tyr Gln
    1730                1735                1740                
Lys Tyr Leu Leu Asp Ser Asn Pro Thr Arg Lys Met Leu Asp His Ile
1745                1750                1755                1760
Ala His Glu Val Gly Leu Lys Lys Arg Val Val Gln Val Trp Phe Gln
                1765                1770                1775    
Asn Thr Arg Ala Arg Glu Arg Lys Gly Gln Phe Arg Ala Val Gly Pro
            1780                1785                1790        
Ala Gln Ala His Arg Arg Cys Pro Phe Cys Arg Ala Leu Phe Lys Ala
        1795                1800                1805            
Lys Thr Ala Leu Glu Ala His Ile Arg Ser Arg His Trp His Glu Ala
    1810                1815                1820                
Lys Arg Ala Gly Tyr Asn Leu Thr Leu Ser Ala Met Leu Leu Asp Cys
1825                1830                1835                1840
Asp Gly Gly Leu Gln Met Lys Gly Asp Ile Phe Asp Gly Thr Ser Phe
                1845                1850                1855    
Ser His Leu Pro Pro Ser Ser Ser Asp Gly Gln Gly Val Pro Leu Ser
            1860                1865                1870        
Pro Val Ser Lys Thr Met Glu Leu Ser Pro Arg Thr Leu Leu Ser Pro
        1875                1880                1885            
Ser Ser Ile Lys Val Glu Gly Ile Glu Asp Phe Glu Ser Pro Ser Met
    1890                1895                1900                
Ser Ser Val Asn Leu Asn Phe Asp Gln Thr Lys Leu Asp Asn Asp Asp
1905                1910                1915                1920
Cys Ser Ser Val Asn Thr Ala Ile Thr Asp Thr Thr Thr Gly Asp Glu
                1925                1930                1935    
Gly Asn Ala Asp Asn Asp Ser Ala Thr Gly Ile Ala Thr Glu Thr Lys
            1940                1945                1950        
Ser Ser Ser Ala Pro Asn Glu Gly Leu Thr Lys Ala Ala Met Met Ala
        1955                1960                1965            
Met Ser Glu Tyr Glu Asp Arg Leu Ser Ser Gly Leu Val Ser Pro Ala
    1970                1975                1980                
Pro Ser Phe Tyr Ser Lys Glu Tyr Asp Asn Glu Gly Thr Val Asp Tyr
1985                1990                1995                2000
Ser Glu Thr Ser Ser Leu Ala Asp Pro Cys Ser Pro Ser Pro Gly Ala
                2005                2010                2015    
Ser Gly Ser Ala Gly Lys Ser Gly Asp Ser Gly Asp Arg Pro Gly Gln
            2020                2025                2030        
Lys Arg Phe Arg Thr Gln Met Thr Asn Leu Gln Leu Lys Val Leu Lys
        2035                2040                2045            
Ser Cys Phe Asn Asp Tyr Arg Thr Pro Thr Met Leu Glu Cys Glu Val
    2050                2055                2060                
Leu Gly Asn Asp Ile Gly Leu Pro Lys Arg Val Val Gln Val Trp Phe
2065                2070                2075                2080
Gln Asn Ala Arg Ala Lys Glu Lys Lys Ser Lys Leu Ser Met Ala Lys
                2085                2090                2095    
His Phe Gly Ile Asn Gln Thr Ser Tyr Glu Gly Pro Lys Thr Glu Cys
            2100                2105                2110        
Thr Leu Cys Gly Ile Lys Tyr Ser Ala Arg Leu Ser Val Arg Asp His
        2115                2120                2125            
Ile Phe Ser Gln Gln His Ile Ser Lys Val Lys Asp Thr Ile Gly Ser
    2130                2135                2140                
Gln Leu Asp Lys Glu Lys Glu Tyr Phe Asp Pro Ala Thr Val Arg Gln
2145                2150                2155                2160
Leu Met Ala Gln Gln Glu Leu Asp Arg Ile Lys Lys Ala Asn Glu Val
                2165                2170                2175    
Leu Gly Leu Ala Ala Gln Gln Gln Gly Met Phe Asp Asn Thr Pro Leu
            2180                2185                2190        
Gln Ala Leu Asn Leu Pro Thr Ala Tyr Pro Ala Leu Gln Gly Ile Pro
        2195                2200                2205            
Pro Val Leu Leu Pro Gly Leu Asn Ser Pro Ser Leu Pro Gly Phe Thr
    2210                2215                2220                
Pro Ser Asn Thr Ala Leu Thr Ser Pro Lys Pro Asn Leu Met Gly Leu
2225                2230                2235                2240
Pro Ser Thr Thr Val Pro Ser Pro Gly Leu Pro Thr Ser Gly Leu Pro
                2245                2250                2255    
Asn Lys Pro Ser Ser Ala Ser Leu Ser Ser Pro Thr Pro Ala Gln Ala
            2260                2265                2270        
Thr Met Ala Met Gly Pro Gln Gln Pro Pro Gln Gln Gln Gln Gln Gln
        2275                2280                2285            
Gln Gln Pro Gln Val Gln Gln Pro Pro Pro Pro Pro Ala Ala Gln Pro
    2290                2295                2300                
Pro Pro Thr Pro Gln Leu Pro Leu Gln Gln Gln Gln Gln Arg Lys Asp
2305                2310                2315                2320
Lys Asp Ser Glu Lys Val Lys Glu Lys Glu Lys Ala His Lys Gly Lys
                2325                2330                2335    
Gly Glu Pro Leu Pro Val Pro Lys Lys Glu Lys Gly Glu Ala Pro Thr
            2340                2345                2350        
Ala Thr Ala Ala Thr Ile Ser Ala Pro Leu Pro Thr Met Glu Tyr Ala
        2355                2360                2365            
Val Asp Pro Ala Gln Leu Gln Ala Leu Gln Ala Ala Leu Thr Ser Asp
    2370                2375                2380                
Pro Thr Ala Leu Leu Thr Ser Gln Phe Leu Pro Tyr Phe Val Pro Gly
2385                2390                2395                2400
Phe Ser Pro Tyr Tyr Ala Pro Gln Ile Pro Gly Ala Leu Gln Ser Gly
                2405                2410                2415    
Tyr Leu Gln Pro Met Tyr Gly Met Glu Gly Leu Phe Pro Tyr Ser Pro
            2420                2425                2430        
Ala Leu Ser Gln Ala Leu Met Gly Leu Ser Pro Gly Ser Leu Leu Gln
        2435                2440                2445            
Gln Tyr Gln Gln Tyr Gln Gln Ser Leu Gln Glu Ala Ile Gln Gln Gln
    2450                2455                2460                
Gln Gln Arg Gln Leu Gln Gln Gln Gln Gln Gln Lys Val Gln Gln Gln
2465                2470                2475                2480
Gln Pro Lys Ala Ser Gln Thr Pro Val Pro Pro Gly Ala Pro Ser Pro
                2485                2490                2495    
Asp Lys Asp Pro Ala Lys Glu Ser Pro Lys Pro Glu Glu Gln Lys Asn
            2500                2505                2510        
Thr Pro Arg Glu Val Ser Pro Leu Leu Pro Lys Leu Pro Glu Glu Pro
        2515                2520                2525            
Glu Ala Glu Ser Lys Ser Ala Asp Ser Leu Tyr Asp Pro Phe Ile Val
    2530                2535                2540                
Pro Lys Val Gln Tyr Lys Leu Val Cys Arg Lys Cys Gln Ala Gly Phe
2545                2550                2555                2560
Ser Asp Glu Glu Ala Ala Arg Ser His Leu Lys Ser Leu Cys Phe Phe
                2565                2570                2575    
Gly Gln Ser Val Val Asn Leu Gln Glu Met Val Leu His Val Pro Thr
            2580                2585                2590        
Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly
        2595                2600                2605            
Gly Gly Gly Gly Gly Ser Tyr His Cys Leu Ala Cys Glu Ser Ala Leu
    2610                2615                2620                
Cys Gly Glu Glu Ala Leu Ser Gln His Leu Glu Ser Ala Leu His Lys
2625                2630                2635                2640
His Arg Thr Ile Thr Arg Ala Ala Arg Asn Ala Lys Glu His Pro Ser
                2645                2650                2655    
Leu Leu Pro His Ser Ala Cys Phe Pro Asp Pro Ser Thr Ala Ser Thr
            2660                2665                2670        
Ser Gln Ser Ala Ala His Ser Asn Asp Ser Pro Pro Pro Pro Ser Ala
        2675                2680                2685            
Ala Ala Pro Ser Ser Ala Ser Pro His Ala Ser Arg Lys Ser Trp Pro
    2690                2695                2700                
Gln Val Val Ser Arg Ala Ser Ala Ala Lys Pro Pro Ser Phe Pro Pro
2705                2710                2715                2720
Leu Ser Ser Ser Ser Thr Val Thr Ser Ser Ser Cys Ser Thr Ser Gly
                2725                2730                2735    
Val Gln Pro Ser Met Pro Thr Asp Asp Tyr Ser Glu Glu Ser Asp Thr
            2740                2745                2750        
Asp Leu Ser Gln Lys Ser Asp Gly Pro Ala Ser Pro Val Glu Gly Pro
        2755                2760                2765            
Lys Asp Pro Ser Cys Pro Lys Asp Ser Gly Leu Thr Ser Val Gly Thr
    2770                2775                2780                
Asp Thr Phe Arg Leu
2785                


<210> 8451
<211> 241
<212> PRT
<213> Homo sapiens

<400> 8451
Met Phe Leu Thr Arg Ser Glu Tyr Asp Arg Gly Val Asn Thr Phe Ser
 1               5                  10                  15      
Pro Glu Gly Arg Leu Phe Gln Val Glu Tyr Ala Ile Glu Ala Ile Lys
            20                  25                  30          
Leu Gly Ser Thr Ala Ile Gly Ile Gln Thr Ser Glu Gly Val Cys Leu
        35                  40                  45              
Ala Val Glu Lys Arg Ile Thr Ser Pro Leu Met Glu Pro Ser Ser Ile
    50                  55                  60                  
Glu Lys Ile Val Glu Ile Asp Ala His Ile Gly Cys Ala Met Ser Gly
65                  70                  75                  80  
Leu Ile Ala Asp Ala Lys Thr Leu Ile Asp Lys Ala Arg Val Glu Thr
                85                  90                  95      
Gln Asn His Trp Phe Thr Tyr Asn Glu Thr Met Thr Val Glu Ser Val
            100                 105                 110         
Thr Gln Ala Val Ser Asn Leu Ala Leu Gln Phe Gly Glu Glu Asp Ala
        115                 120                 125             
Asp Pro Gly Ala Met Ser Arg Pro Phe Gly Val Ala Leu Leu Phe Gly
    130                 135                 140                 
Gly Val Asp Glu Lys Gly Pro Gln Leu Phe His Met Asp Pro Ser Gly
145                 150                 155                 160 
Thr Phe Val Gln Cys Asp Ala Arg Ala Ile Gly Ser Ala Ser Glu Gly
                165                 170                 175     
Ala Gln Ser Ser Leu Gln Glu Val Tyr His Lys Ser Met Thr Leu Lys
            180                 185                 190         
Glu Ala Ile Lys Ser Ser Leu Ile Ile Leu Lys Gln Val Met Glu Glu
        195                 200                 205             
Lys Leu Asn Ala Thr Asn Ile Glu Leu Ala Thr Val Gln Pro Gly Gln
    210                 215                 220                 
Asn Phe His Met Phe Thr Lys Glu Glu Leu Glu Glu Val Ile Lys Asp
225                 230                 235                 240 
Ile
    


<210> 8452
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8452
Met Ser Gly Ser Thr Glu Val Lys Pro Ala Val Thr Thr Ala Arg Lys
 1               5                  10                  15      
Ile Gln Thr Arg Thr Phe Ser Leu Lys Glu Leu Lys Glu Lys Ala Arg
            20                  25                  30          
Pro Asn Phe Ser Asn Gln Ala Asp His Pro Val Leu Ala Gly Thr Gly
        35                  40                  45              
Phe Trp Pro Ala Leu Pro Val Arg Gly Glu Glu Thr Thr Asp Leu Arg
    50                  55                  60                  
Lys Gln Ala Glu Thr Ala Pro Asp Gly Pro Asp Ser Gly Glu Tyr Leu
65                  70                  75                  80  
Leu His Leu Ile Leu Tyr Asn Trp Cys Cys Ser Arg Tyr Ala Asp Arg
                85                  90                  95      
Arg Gln Pro Gln Gly Thr Asn Ala Arg Lys Trp Gln Gly Lys Lys Thr
            100                 105                 110         
Glu Ala Trp Arg Gly Tyr Asn Ile Thr
        115                 120     


<210> 8453
<211> 1302
<212> PRT
<213> Homo sapiens

<400> 8453
Met Asp Asp Leu Lys Ile Asn Thr Asp Ile Thr Gly Ala Lys Glu Glu
 1               5                  10                  15      
Leu Leu Asp Asp Asn Asn Phe Ile Ser Asp Lys Glu Ser Gly Val His
            20                  25                  30          
Lys Pro Lys Asp Cys Gln Thr Ser Phe Gln Lys Asn Asn Thr Leu Thr
        35                  40                  45              
Leu Pro Glu Glu Leu Ser Lys Asp Lys Ser Glu Asn Ala Leu Ser Gly
    50                  55                  60                  
Gly Gln Ser Ser Leu Phe Ile His Ala Gly Ala Pro Thr Val Ser Ser
65                  70                  75                  80  
Glu Asn Phe Ile Leu Pro Lys Gly Ala Ala Val Asn Gly Pro Val Ser
                85                  90                  95      
His Ser Ser Leu Thr Lys Thr Ser Asn Met Asn Lys Gly Ser Val Ser
            100                 105                 110         
Leu Thr Thr Gly Gln Pro Val Asp Gln Pro Thr Thr Glu Ser Cys Ser
        115                 120                 125             
Thr Leu Lys Val Ala Ala Asp Leu Gln Leu Ser Thr Pro Gln Lys Ala
    130                 135                 140                 
Ser Gln His Gln Val Leu Phe Leu Leu Ser Asp Val Ala His Ala Lys
145                 150                 155                 160 
Asn Pro Thr His Ser Asn Lys Lys Leu Pro Thr Ser Ala Ser Val Gly
                165                 170                 175     
Cys Asp Ile Gln Asn Ser Val Gly Ser Asn Ile Lys Ser Asp Gly Thr
            180                 185                 190         
Leu Ile Asn Gln Val Glu Val Gly Glu Asp Gly Glu Asp Leu Leu Val
        195                 200                 205             
Lys Asp Asp Cys Val Asn Thr Val Thr Gly Ile Ser Ser Gly Thr Asp
    210                 215                 220                 
Gly Phe Arg Ser Glu Asn Asp Thr Asn Trp Asp Pro Gln Lys Glu Phe
225                 230                 235                 240 
Ile Gln Phe Leu Met Thr Asn Glu Glu Thr Val Asp Lys Ala Pro Pro
                245                 250                 255     
His Ser Lys Ile Gly Leu Glu Lys Lys Arg Lys Arg Lys Met Asp Val
            260                 265                 270         
Ser Lys Ile Thr Arg Tyr Thr Glu Asp Cys Phe Ser Asp Ser Asn Cys
        275                 280                 285             
Val Pro Asn Lys Ser Lys Met Gln Glu Val Asp Phe Leu Glu Gln Asn
    290                 295                 300                 
Glu Glu Leu Gln Ala Val Asp Ser Gln Lys Tyr Ala Leu Ser Lys Val
305                 310                 315                 320 
Lys Pro Glu Ser Thr Asp Glu Asp Leu Glu Ser Val Asp Ala Phe Gln
                325                 330                 335     
His Leu Ile Tyr Asn Pro Asp Lys Cys Gly Glu Glu Ser Ser Pro Val
            340                 345                 350         
His Thr Ser Thr Phe Leu Ser Asn Thr Leu Lys Lys Lys Cys Glu Glu
        355                 360                 365             
Ser Asp Ser Glu Ser Pro Ala Thr Phe Ser Thr Glu Glu Pro Ser Phe
    370                 375                 380                 
Tyr Pro Cys Thr Lys Cys Asn Val Asn Phe Arg Glu Lys Lys His Leu
385                 390                 395                 400 
His Arg His Met Met Tyr His Leu Asp Gly Asn Ser His Phe Arg His
                405                 410                 415     
Leu Asn Val Pro Arg Pro Tyr Ala Cys Arg Glu Cys Gly Arg Thr Phe
            420                 425                 430         
Arg Asp Arg Asn Ser Leu Leu Lys His Met Ile Ile His Gln Glu Arg
        435                 440                 445             
Arg Gln Lys Leu Met Glu Glu Ile Arg Glu Leu Lys Glu Leu Gln Asp
    450                 455                 460                 
Glu Gly Arg Ser Ala Arg Leu Gln Cys Pro Gln Cys Val Phe Gly Thr
465                 470                 475                 480 
Asn Cys Pro Lys Thr Phe Val Gln His Ala Lys Thr His Glu Lys Asp
                485                 490                 495     
Lys Arg Tyr Tyr Cys Cys Glu Glu Cys Asn Phe Met Ala Val Thr Glu
            500                 505                 510         
Asn Glu Leu Glu Cys His Arg Gly Ile Ala His Gly Ala Val Val Lys
        515                 520                 525             
Cys Pro Met Val Thr Ser Asp Ile Ala Gln Arg Lys Thr Gln Lys Lys
    530                 535                 540                 
Thr Phe Met Lys Asp Ser Val Val Gly Ser Ser Lys Lys Ser Ala Thr
545                 550                 555                 560 
Tyr Ile Cys Lys Met Cys Pro Phe Thr Thr Ser Ala Lys Ser Val Leu
                565                 570                 575     
Lys Lys His Thr Glu Tyr Leu His Ser Ser Ser Cys Val Asp Ser Phe
            580                 585                 590         
Gly Ser Pro Leu Gly Leu Asp Lys Arg Lys Asn Asp Ile Leu Glu Glu
        595                 600                 605             
Pro Val Asp Ser Asp Ser Thr Lys Thr Leu Thr Lys Gln Gln Ser Thr
    610                 615                 620                 
Thr Phe Pro Lys Asn Ser Ala Leu Lys Gln Asp Val Lys Arg Thr Phe
625                 630                 635                 640 
Gly Ser Thr Ser Gln Ser Ser Ser Phe Ser Lys Ile His Lys Arg Pro
                645                 650                 655     
His Arg Ile Gln Lys Ala Arg Lys Ser Ile Ala Gln Ser Gly Val Asn
            660                 665                 670         
Met Cys Asn Gln Asn Ser Ser Pro His Lys Asn Val Thr Ile Lys Ser
        675                 680                 685             
Ser Val Asp Gln Lys Pro Lys Tyr Phe His Gln Ala Ala Lys Glu Lys
    690                 695                 700                 
Ser Asn Ala Lys Ala Asn Ser His Tyr Leu Tyr Arg His Lys Tyr Glu
705                 710                 715                 720 
Asn Tyr Arg Met Ile Lys Lys Ser Gly Glu Ser Tyr Pro Val His Phe
                725                 730                 735     
Lys Lys Glu Glu Ala Ser Ser Leu Asn Ser Leu His Leu Phe Ser Ser
            740                 745                 750         
Ser Ser Asn Ser His Asn Asn Phe Ile Ser Asp Pro His Lys Pro Asp
        755                 760                 765             
Ala Lys Arg Pro Glu Ser Phe Lys Asp His Arg Arg Val Ala Val Lys
    770                 775                 780                 
Arg Val Ile Lys Glu Ser Lys Lys Glu Ser Ser Val Gly Gly Glu Asp
785                 790                 795                 800 
Leu Asp Ser Tyr Pro Asp Phe Leu His Lys Met Thr Val Val Val Leu
                805                 810                 815     
Gln Lys Leu Asn Ser Ala Glu Lys Lys Asp Ser Tyr Glu Thr Glu Asp
            820                 825                 830         
Glu Ser Ser Trp Asp Asn Val Glu Leu Gly Asp Tyr Thr Thr Gln Ala
        835                 840                 845             
Ile Glu Asp Glu Thr Tyr Ser Asp Ile Asn Gln Glu His Val Asn Leu
    850                 855                 860                 
Phe Pro Leu Phe Lys Ser Lys Val Glu Gly Gln Glu Pro Gly Glu Asn
865                 870                 875                 880 
Ala Thr Leu Ser Tyr Asp Gln Asn Asp Gly Phe Tyr Phe Glu Tyr Tyr
                885                 890                 895     
Glu Asp Thr Gly Ser Asn Asn Phe Leu His Glu Ile His Asp Pro Gln
            900                 905                 910         
His Leu Glu Thr Ala Asp Ala Ser Leu Ser Lys His Ser Ser Val Phe
        915                 920                 925             
His Trp Thr Asp Leu Ser Leu Glu Lys Lys Ser Cys Pro Tyr Cys Pro
    930                 935                 940                 
Ala Thr Phe Glu Thr Gly Val Gly Leu Ser Asn His Val Arg Gly His
945                 950                 955                 960 
Leu His Arg Ala Gly Leu Ser Tyr Glu Ala Arg His Val Val Ser Pro
                965                 970                 975     
Glu Gln Ile Ala Thr Ser Asp Lys Met Gln His Phe Lys Arg Thr Gly
            980                 985                 990         
Thr Gly Thr Pro Val Lys Arg Val Arg Lys Ala Ile Glu Lys Ser Glu
        995                 1000                1005            
Thr Thr Ser Glu His Thr Cys Gln Leu Cys Gly Gly Trp Phe Asp Thr
    1010                1015                1020                
Lys Ile Gly Leu Ser Asn His Val Arg Gly His Leu Lys Arg Leu Gly
1025                1030                1035                1040
Lys Thr Lys Trp Asp Ala His Lys Ser Pro Ile Cys Val Leu Asn Glu
                1045                1050                1055    
Met Met Gln Asn Glu Glu Lys Tyr Glu Lys Ile Leu Lys Ala Leu Asn
            1060                1065                1070        
Ser Arg Arg Ile Ile Pro Arg Pro Phe Val Ala Gln Lys Leu Ala Ser
        1075                1080                1085            
Ser Asp Asp Phe Ile Ser Gln Asn Val Ile Pro Leu Glu Ala Tyr Arg
    1090                1095                1100                
Asn Gly Leu Lys Thr Glu Ala Leu Ser Val Ser Ala Ser Glu Glu Glu
1105                1110                1115                1120
Gly Leu Asn Phe Leu Asn Glu Tyr Asp Glu Thr Lys Pro Glu Leu Pro
                1125                1130                1135    
Ser Gly Lys Lys Asn Gln Ser Leu Thr Leu Ile Glu Leu Leu Lys Asn
            1140                1145                1150        
Lys Arg Met Gly Glu Glu Arg Asn Ser Ala Ile Ser Pro Gln Lys Ile
        1155                1160                1165            
His Asn Gln Thr Ala Arg Lys Arg Phe Val Gln Lys Cys Val Leu Pro
    1170                1175                1180                
Leu Asn Glu Asp Ser Pro Leu Met Tyr Gln Pro Gln Lys Met Asp Leu
1185                1190                1195                1200
Thr Met His Ser Ala Leu Asp Cys Lys Gln Lys Lys Ser Arg Ser Arg
                1205                1210                1215    
Ser Gly Ser Lys Lys Lys Met Leu Thr Leu Pro His Gly Ala Asp Glu
            1220                1225                1230        
Val Tyr Ile Leu Arg Cys Arg Phe Cys Gly Leu Val Phe Arg Gly Pro
        1235                1240                1245            
Leu Ser Val Gln Glu Asp Trp Ile Lys His Leu Gln Arg His Ile Val
    1250                1255                1260                
Asn Ala Asn Leu Pro Arg Thr Gly Ala Gly Met Val Glu Val Thr Ser
1265                1270                1275                1280
Leu Leu Lys Lys Pro Ala Ser Ile Thr Glu Thr Ser Phe Ser Leu Leu
                1285                1290                1295    
Met Ala Glu Ala Ala Ser
            1300        


<210> 8454
<211> 650
<212> PRT
<213> Homo sapiens

<400> 8454
Met Met Tyr His Leu Asp Gly Asn Ser His Phe Arg His Leu Asn Val
 1               5                  10                  15      
Pro Arg Pro Tyr Ala Cys Arg Glu Cys Gly Arg Thr Phe Arg Asp Arg
            20                  25                  30          
Asn Ser Leu Leu Lys His Met Ile Ile His Gln Glu Arg Arg Gln Lys
        35                  40                  45              
Leu Met Glu Glu Ile Arg Glu Leu Lys Glu Leu Gln Asp Glu Gly Arg
    50                  55                  60                  
Ser Ala Arg Leu Gln Cys Pro Gln Cys Val Phe Gly Thr Asn Cys Pro
65                  70                  75                  80  
Lys Thr Phe Val Gln His Ala Lys Thr His Glu Lys Asp Lys Arg Tyr
                85                  90                  95      
Tyr Cys Cys Glu Glu Cys Asn Phe Met Ala Val Thr Glu Asn Glu Leu
            100                 105                 110         
Glu Cys His Arg Gly Ile Ala His Gly Ala Val Val Lys Cys Pro Met
        115                 120                 125             
Val Thr Ser Asp Ile Ala Gln Lys Lys Thr Gln Lys Lys Thr Phe Met
    130                 135                 140                 
Lys Asp Ser Val Val Gly Ser Ser Lys Lys Ser Ala Thr Tyr Ile Cys
145                 150                 155                 160 
Lys Met Cys Pro Phe Thr Thr Ser Ala Lys Ser Val Leu Lys Lys His
                165                 170                 175     
Thr Glu Tyr Leu His Ser Ser Ser Cys Val Asp Ser Phe Gly Ser Pro
            180                 185                 190         
Leu Gly Leu Asp Lys Arg Lys Asn Asp Ile Leu Glu Glu Pro Val Asp
        195                 200                 205             
Ser Asp Ser Thr Lys Thr Leu Thr Lys Gln Gln Ser Thr Thr Phe Pro
    210                 215                 220                 
Lys Asn Ser Ala Leu Lys Gln Asp Val Lys Arg Thr Phe Gly Ser Thr
225                 230                 235                 240 
Ser Gln Ser Ser Ser Phe Ser Lys Ile His Lys Arg Pro His Arg Ile
                245                 250                 255     
Gln Lys Ala Arg Lys Ser Ile Ala Gln Ser Gly Val Asn Met Cys Asn
            260                 265                 270         
Gln Asn Ser Ser Pro His Lys Asn Val Thr Ile Lys Ser Ser Val Asp
        275                 280                 285             
Gln Lys Pro Lys Tyr Phe His Gln Ala Ala Lys Glu Lys Ser Asn Ala
    290                 295                 300                 
Lys Ala Asn Ser His Tyr Leu Tyr Arg His Lys Tyr Glu Asn Tyr Arg
305                 310                 315                 320 
Met Ile Lys Lys Ser Gly Glu Ser Tyr Pro Val His Phe Lys Lys Glu
                325                 330                 335     
Glu Ala Ser Ser Leu Asn Ser Leu His Leu Phe Ser Ser Ser Ser Asn
            340                 345                 350         
Ser His Asn Asn Phe Ile Ser Asp Pro His Lys Pro Asp Ala Lys Arg
        355                 360                 365             
Pro Glu Ser Phe Lys Asp His Arg Arg Val Ala Val Lys Arg Val Ile
    370                 375                 380                 
Lys Glu Ser Lys Lys Glu Ser Ser Val Gly Gly Glu Asp Leu Asp Ser
385                 390                 395                 400 
Tyr Pro Asp Phe Leu His Lys Met Thr Val Val Val Leu Gln Lys Leu
                405                 410                 415     
Asn Ser Ala Glu Lys Lys Asp Ser Tyr Glu Thr Glu Asp Glu Ser Ser
            420                 425                 430         
Trp Asp Asn Val Glu Leu Gly Asp Tyr Thr Thr Gln Ala Ile Glu Asp
        435                 440                 445             
Glu Thr Tyr Ser Asp Ile Asn Gln Glu His Val Asn Leu Phe Pro Leu
    450                 455                 460                 
Phe Lys Ser Lys Val Glu Gly Gln Glu Pro Gly Glu Asn Ala Thr Leu
465                 470                 475                 480 
Ser Tyr Asp Gln Asn Asp Gly Phe Tyr Phe Glu Tyr Tyr Glu Asp Thr
                485                 490                 495     
Gly Ser Asn Asn Phe Leu His Glu Ile His Asp Pro Gln His Leu Glu
            500                 505                 510         
Thr Ala Asp Ala Ser Leu Ser Lys His Ser Ser Val Phe His Trp Thr
        515                 520                 525             
Asp Leu Ser Leu Glu Lys Lys Ser Cys Pro Tyr Cys Pro Ala Thr Phe
    530                 535                 540                 
Glu Thr Gly Val Gly Leu Ser Asn His Val Arg Gly His Leu His Arg
545                 550                 555                 560 
Ala Gly Leu Ser Tyr Glu Ala Arg His Val Val Ser Pro Glu Gln Ile
                565                 570                 575     
Ala Thr Ser Asp Lys Met Gln His Phe Lys Arg Thr Gly Thr Gly Thr
            580                 585                 590         
Pro Val Lys Arg Val Arg Lys Ala Ile Glu Lys Ser Glu Thr Thr Ser
        595                 600                 605             
Glu His Thr Cys Gln Leu Cys Gly Gly Trp Phe Asp Thr Lys Ile Gly
    610                 615                 620                 
Leu Ser Asn His Val Arg Ser Pro Leu Glu Arg Leu Gly Lys Thr Lys
625                 630                 635                 640 
Trp Asp Ala His Lys Ser Pro Ile Trp Val
                645                 650 


<210> 8455
<211> 239
<212> PRT
<213> Homo sapiens

<400> 8455
Met Gln Asp Pro Asn Thr Asp Thr Glu Trp Asn Asp Ile Leu Asp Lys
 1               5                  10                  15      
Lys Gly Ile Leu Pro Thr Lys Glu Ser Ile Lys Glu Ser Glu Glu Lys
            20                  25                  30          
Ala Glu Glu Glu Gln His Ile Leu Gln Gln Ser Val Val Thr Thr Tyr
        35                  40                  45              
Glu Asp Met Thr Leu Glu Glu Leu Glu Asp His Glu Asp Glu Phe Asn
    50                  55                  60                  
Glu Glu Asp Glu His Ala Ile Glu Met Tyr Arg Trp Gln Arg Leu Ala
65                  70                  75                  80  
Glu Gly Lys Ala Ile Lys Leu Lys Asn Lys Phe Gly Glu Val Leu Glu
                85                  90                  95      
Ile Ser Gly Lys Tyr Tyr Val Gln Glu Val Thr Lys Ala Ser Glu Gly
            100                 105                 110         
Leu Trp Val Ile Leu His Leu Cys Lys Arg Gly Ile Pro Leu Cys Ala
        115                 120                 125             
Leu Ile Asn Gln His Leu Ser Gly Leu Ala Arg Lys Phe Pro Asp Val
    130                 135                 140                 
Lys Phe Ile Lys Ala Asn Ser Thr Thr Cys Ile Pro Asn Tyr Pro Asp
145                 150                 155                 160 
Arg Asn Leu Pro Met Val Phe Val Tyr Leu Glu Gly Asp Ile Lys Ala
                165                 170                 175     
Gln Leu Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr Arg Asp
            180                 185                 190         
Glu Leu Gly Trp Lys Leu Ser Glu Ser Arg Ala Val Lys Thr Asp Leu
        195                 200                 205             
Glu Glu Asn Pro Lys Lys Pro Ile Glu Gly Val Leu Leu Ser Ser Val
    210                 215                 220                 
Gln Ser Ser Val Pro Met Arg Arg Asp Ser Asp Ser Lys Gly Asp
225                 230                 235                 


<210> 8456
<211> 405
<212> PRT
<213> Homo sapiens

<400> 8456
Pro Arg Val Arg Lys Arg Arg Lys Trp Arg Pro Glu Pro Ser Leu Gly
 1               5                  10                  15      
Val Leu Asp Ala Glu Arg Met Ala Ser Ser Ser Pro Asp Ala Pro Cys
            20                  25                  30          
Ser Cys Asp Cys Phe Val Ser Val Pro Pro Ala Ser Ala Ile Pro Ala
        35                  40                  45              
Val Ile Phe Ala Lys Asn Ser Asp Arg Pro Arg Asp Glu Val Gln Glu
    50                  55                  60                  
Val Val Phe Ile Pro Ala Gly Thr His Val Pro Gly Ser Arg Leu Gln
65                  70                  75                  80  
Cys Thr Tyr Ile Glu Val Glu Gln Val Gly Lys Thr His Ala Val Ile
                85                  90                  95      
Leu Ser Arg Pro Ser Trp Leu Trp Gly Ala Glu Met Gly Ala Asn Glu
            100                 105                 110         
Leu Gly Val Cys Ile Gly Asn Glu Ala Val Trp Thr Lys Glu Pro Val
        115                 120                 125             
Gly Gln Gly Glu Ala Leu Leu Gly Met Asp Leu Leu Arg Leu Ala Leu
    130                 135                 140                 
Glu Arg Ser Ser Thr Ala Gln Glu Ala Val His Val Ile Ala Gly Leu
145                 150                 155                 160 
Leu Asp Arg Tyr Gly Gln Gly Gly Ser Cys Arg Glu Asp Pro Glu Pro
                165                 170                 175     
Phe Cys Tyr His Asn Thr Phe Leu Leu Ala Asp Arg Thr Glu Ala Trp
            180                 185                 190         
Val Leu Glu Thr Ala Gly Ser Leu Trp Ala Ala Gln Arg Ile Gln Gly
        195                 200                 205             
Gly Ala Arg Asn Ile Ser Asn Gln Leu Ser Ile Gly Thr Asp Ile Ser
    210                 215                 220                 
Ala Glu His Pro Glu Leu Arg Ser His Ala Lys Ala Gln Gly Asn Ile
225                 230                 235                 240 
Thr Ala Glu Val Met Met Gly Ile Leu Arg Asp Lys Glu Ser Gly Ile
                245                 250                 255     
Cys Met Asp Ser Gly Gly Phe Arg Thr Thr Ala Ser Met Val Ser Val
            260                 265                 270         
Leu Pro Gln Asp Pro Thr Lys Pro Cys Val His Phe Leu Thr Ala Thr
        275                 280                 285             
Pro Asp Pro Ser Arg Ser Val Phe Lys Pro Phe Ile Phe Glu Val Gly
    290                 295                 300                 
Val Ser Gln Ser Pro Gln Val Leu Ser Pro Thr Phe Gly Ala Gln Asp
305                 310                 315                 320 
Pro Val Arg Ile Leu Pro Arg Phe Gln Thr Arg Val Asp Arg Arg His
                325                 330                 335     
Ser Leu Tyr Arg Gly His Gln Ala Ala Leu Gly Leu Met Glu Asp Glu
            340                 345                 350         
Gln Glu Gln Ala Gln Gln Leu Arg Lys Lys Gln Gln Arg Leu Glu Gln
        355                 360                 365             
Glu Gly Leu Glu Ala Leu Arg Gly Leu Leu Thr Gly Glu Gln Thr Pro
    370                 375                 380                 
Pro Ala Gln Gly Leu Gly Ser Leu Phe Gln Ala Phe Val Glu Arg Glu
385                 390                 395                 400 
Glu Gln Ala Tyr Ala
                405 


<210> 8457
<211> 1124
<212> PRT
<213> Homo sapiens

<400> 8457
Gly Leu Ser Thr Arg Ala Gly Gln His Pro Ser Ser Cys Asp Arg Ala
 1               5                  10                  15      
Gln Glu Glu Ala Glu Thr Glu Thr Met Pro Gly Lys Leu Lys Val Lys
            20                  25                  30          
Ile Val Ala Gly Arg His Leu Pro Val Met Asp Arg Ala Ser Asp Leu
        35                  40                  45              
Thr Asp Ala Phe Val Glu Val Lys Phe Gly Asn Thr Thr Phe Lys Thr
    50                  55                  60                  
Asp Val Tyr Leu Lys Ser Leu Asn Pro Gln Trp Asn Ser Glu Trp Phe
65                  70                  75                  80  
Lys Phe Glu Val Asp Asp Glu Asp Leu Gln Asp Glu Pro Leu Gln Ile
                85                  90                  95      
Thr Val Leu Asp His Asp Thr Tyr Ser Ala Asn Asp Ala Ile Gly Lys
            100                 105                 110         
Val Tyr Ile Asp Ile Asp Pro Leu Leu Tyr Ser Glu Ala Ala Thr Val
        115                 120                 125             
Ile Ser Gly Trp Phe Pro Ile Tyr Asp Thr Ile His Gly Ile Arg Gly
    130                 135                 140                 
Glu Ile Asn Val Val Val Lys Val Asp Leu Phe Asn Asp Leu Asn Arg
145                 150                 155                 160 
Phe Arg Gln Ser Ser Cys Gly Val Lys Phe Phe Cys Thr Thr Ser Ile
                165                 170                 175     
Pro Lys Cys Tyr Arg Ala Val Ile Ile His Gly Phe Val Glu Glu Leu
            180                 185                 190         
Val Val Asn Glu Asp Pro Glu Tyr Gln Trp Ile Asp Arg Ile Arg Thr
        195                 200                 205             
Pro Arg Ala Ser Asn Glu Ala Arg Gln Arg Leu Ile Ser Leu Met Ser
    210                 215                 220                 
Gly Glu Leu Gln Arg Lys Ile Gly Leu Lys Val Leu Glu Met Arg Gly
225                 230                 235                 240 
Asn Ala Val Val Gly Tyr Leu Gln Cys Phe Asp Leu Glu Gly Glu Ser
                245                 250                 255     
Gly Leu Val Val Arg Ala Ile Gly Thr Ala Cys Thr Leu Asp Lys Leu
            260                 265                 270         
Ser Ser Pro Ala Ala Phe Leu Pro Ala Cys Asn Ser Pro Ser Lys Glu
        275                 280                 285             
Met Lys Glu Ser Pro Leu Val His Pro Pro Ser His Gly Cys Arg Ser
    290                 295                 300                 
Thr His Asn Ser Pro Ile His Thr Ala Thr Gly Ser Arg Leu Thr Gln
305                 310                 315                 320 
Asn Phe Ser Val Ser Val Pro Thr Leu Ile Tyr Thr Gly Thr Arg Leu
                325                 330                 335     
Leu Arg Leu Gln Ser Trp Gly Asp Ala Gly His Gly Gln Ser Gly Cys
            340                 345                 350         
Arg Gly Arg Gln Ala Gly Met Gly Ser Gly Ser Ala Gly Lys Glu Gly
        355                 360                 365             
Gly Pro Phe Lys Ala Leu Leu Arg Gln Gln Thr Gln Ser Ala Leu Glu
    370                 375                 380                 
Gln Arg Gly Gly Ser Pro His Arg Phe Cys Arg Arg Arg Glu Phe Pro
385                 390                 395                 400 
Phe Phe Thr Leu Thr Ala Phe Pro Pro Gly Phe Leu Val His Val Gly
                405                 410                 415     
Gly Val Val Ser Ala Arg Ser Val Lys Leu Leu Asp Arg Ile His Asn
            420                 425                 430         
Pro Ala Phe Val Gly Ile Met Gly Asn Thr Arg Ser Tyr Lys Leu Leu
        435                 440                 445             
Asp Trp Asn Ser Phe Asn Ser Asp Glu Pro Glu Thr Arg Asp Ala Trp
    450                 455                 460                 
Trp Ala Glu Ile Arg Gln Glu Ile Lys Ser His Ala Lys Ala Leu Gly
465                 470                 475                 480 
Cys His Ala Val Val Gly Tyr Ser Glu Ser Thr Ser Ile Cys Glu Glu
                485                 490                 495     
Val Cys Ile Leu Ser Ala Ser Gly Thr Ala Ala Val Leu Asn Pro Arg
            500                 505                 510         
Phe Leu Gln Asp Gly Thr Val Glu Gly Cys Leu Glu Gln Arg Leu Glu
        515                 520                 525             
Glu Asn Leu Pro Thr Arg Cys Gly Phe Cys His Ile Pro Tyr Asp Glu
    530                 535                 540                 
Leu Asn Met Pro Phe Pro Ala His Leu Thr Tyr Cys Tyr Asn Cys Arg
545                 550                 555                 560 
Lys Gln Lys Val Pro Asp Val Leu Phe Thr Thr Ile Asp Leu Pro Thr
                565                 570                 575     
Asp Ala Thr Val Ile Gly Lys Gly Cys Leu Ile Gln Ala Arg Leu Cys
            580                 585                 590         
Arg Leu Lys Lys Lys Ala Gln Ala Glu Ala Asn Ala Thr Ala Ile Ser
        595                 600                 605             
Asn Leu Leu Pro Phe Met Glu Tyr Glu Val His Thr Gln Leu Met Asn
    610                 615                 620                 
Lys Leu Lys Leu Lys Gly Met Asn Ala Leu Phe Gly Leu Arg Ile Gln
625                 630                 635                 640 
Ile Thr Val Gly Glu Asn Met Leu Met Gly Leu Ala Ser Ala Thr Gly
                645                 650                 655     
Val Tyr Leu Ala Ala Leu Pro Thr Pro Gly Gly Ile Gln Ile Ala Gly
            660                 665                 670         
Lys Thr Pro Asn Asp Gly Ser Tyr Glu Gln His Ile Ser His Met Gln
        675                 680                 685             
Lys Lys Ile Asn Asp Thr Ile Ala Lys Asn Lys Glu Leu Tyr Glu Ile
    690                 695                 700                 
Asn Pro Pro Glu Ile Ser Glu Glu Ile Ile Gly Ser Pro Ile Pro Glu
705                 710                 715                 720 
Pro Arg Gln Arg Ser Arg Leu Leu Arg Ser Gln Ser Glu Ser Ser Asp
                725                 730                 735     
Glu Val Thr Glu Leu Asp Leu Ser His Gly Lys Lys Asp Ala Phe Val
            740                 745                 750         
Leu Glu Ile Asp Asp Thr Asp Ala Met Glu Asp Val His Ser Leu Leu
        755                 760                 765             
Thr Asp Val Pro Pro Pro Ser Gly Phe Tyr Ser Cys Asn Thr Glu Ile
    770                 775                 780                 
Met Pro Gly Ile Asn Asn Trp Thr Ser Glu Ile Gln Met Phe Thr Ser
785                 790                 795                 800 
Val Arg Val Ile Arg Leu Ser Ser Leu Asn Leu Thr Asn Gln Ala Leu
                805                 810                 815     
Asn Lys Asn Phe Asn Asp Leu Cys Glu Asn Leu Leu Lys Ser Leu Tyr
            820                 825                 830         
Phe Lys Leu Arg Ser Met Ile Pro Cys Cys Leu Cys His Val Asn Phe
        835                 840                 845             
Thr Val Ser Leu Pro Glu Asp Glu Leu Ile Gln Val Thr Val Thr Ala
    850                 855                 860                 
Val Ala Ile Thr Phe Asp Lys Asn Gln Ala Leu Gln Thr Thr Lys Thr
865                 870                 875                 880 
Pro Val Glu Lys Ser Leu Gln Arg Ala Ser Thr Asp Asn Glu Glu Leu
                885                 890                 895     
Leu Gln Phe Pro Leu Glu Leu Cys Ser Asp Ser Leu Pro Ser His Pro
            900                 905                 910         
Phe Pro Pro Ala Lys Glu His Leu Glu Ser Ala Ser Ser Asn Ser Gly
        915                 920                 925             
Ile Pro Ala Ala Gln Arg Ala Thr Ser Val Asp Tyr Ser Ser Phe Ala
    930                 935                 940                 
Asp Arg Cys Ser Ser Trp Ile Glu Leu Ile Lys Leu Lys Ala Gln Thr
945                 950                 955                 960 
Ile Arg Arg Gly Ser Ile Lys Thr Thr Met Thr Val Glu Lys Ala Ser
                965                 970                 975     
Pro Val Gly Asp Gly Asn Phe Arg Asn Arg Ser Ala Pro Pro Cys Ala
            980                 985                 990         
Asn Ser Thr Val Gly Val Val Lys Met Thr Pro Leu Ser Phe Ile Pro
        995                 1000                1005            
Gly Ala Lys Ile Thr Lys Tyr Leu Gly Ile Ile Asn Met Phe Phe Ile
    1010                1015                1020                
Arg Glu Thr Thr Ser Leu Arg Glu Glu Gly Gly Val Ser Gly Phe Leu
1025                1030                1035                1040
His Ala Phe Ile Ala Glu Val Phe Ala Met Val Arg Ala His Val Ala
                1045                1050                1055    
Ala Leu Gly Gly Asn Ala Val Val Ser Tyr Ile Met Lys Gln Cys Val
            1060                1065                1070        
Phe Met Glu Asn Pro Asn Lys Asn Gln Ala Gln Cys Leu Ile Asn Val
        1075                1080                1085            
Ser Gly Asp Ala Val Val Phe Val Arg Glu Ser Asp Leu Glu Val Val
    1090                1095                1100                
Ser Ser Gln Gln Pro Thr Thr Asn Cys Gln Ser Ser Cys Thr Glu Gly
1105                1110                1115                1120
Glu Val Thr Thr
                


<210> 8458
<211> 1005
<212> PRT
<213> Homo sapiens

<400> 8458
Ala Glu Thr Glu Thr Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala
 1               5                  10                  15      
Gly Arg His Leu Pro Val Met Asp Arg Ala Ser Asp Leu Thr Asp Ala
            20                  25                  30          
Phe Val Glu Val Lys Phe Gly Asn Thr Thr Phe Lys Thr Asp Val Tyr
        35                  40                  45              
Leu Lys Ser Leu Asn Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu
    50                  55                  60                  
Val Asp Asp Glu Asp Leu Gln Asp Glu Pro Leu Gln Ile Thr Val Leu
65                  70                  75                  80  
Asp His Asp Thr Tyr Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile
                85                  90                  95      
Asp Ile Asp Pro Leu Leu Tyr Ser Glu Ala Ala Thr Val Ile Ser Gly
            100                 105                 110         
Trp Phe Pro Ile Tyr Asp Thr Ile His Gly Ile Arg Gly Glu Ile Asn
        115                 120                 125             
Val Val Val Lys Val Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln
    130                 135                 140                 
Ser Ser Cys Gly Val Lys Phe Phe Cys Thr Thr Ser Ile Pro Lys Cys
145                 150                 155                 160 
Tyr Arg Ala Val Ile Ile His Gly Phe Val Glu Glu Leu Val Val Asn
                165                 170                 175     
Glu Asp Pro Glu Tyr Gln Trp Ile Asp Arg Ile Arg Thr Pro Arg Ala
            180                 185                 190         
Ser Asn Glu Ala Arg Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu
        195                 200                 205             
Gln Arg Lys Ile Gly Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val
    210                 215                 220                 
Val Gly Tyr Leu Gln Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val
225                 230                 235                 240 
Val Arg Ala Ile Gly Thr Ala Cys Thr Leu Asp Lys Leu Ser Ser Pro
                245                 250                 255     
Ala Ala Phe Leu Pro Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu
            260                 265                 270         
Ile Pro Phe Asn Glu Asp Pro Asn Pro Asn Thr His Ser Ser Gly Pro
        275                 280                 285             
Ser Thr Pro Leu Lys Asn Gln Thr Tyr Ser Phe Ser Pro Ser Lys Ser
    290                 295                 300                 
Tyr Ser Arg Gln Ser Ser Ser Ser Asp Thr Asp Leu Ser Leu Thr Pro
305                 310                 315                 320 
Lys Thr Gly Met Gly Ser Gly Ser Ala Gly Lys Glu Gly Gly Pro Phe
                325                 330                 335     
Lys Ala Leu Leu Arg Gln Gln Thr Gln Ser Ala Leu Glu Gln Arg Glu
            340                 345                 350         
Phe Pro Phe Phe Thr Leu Thr Ala Phe Pro Pro Gly Phe Leu Val His
        355                 360                 365             
Val Gly Gly Val Val Ser Ala Arg Ser Val Lys Leu Leu Asp Arg Ile
    370                 375                 380                 
His Asn Pro Asp Glu Pro Glu Thr Arg Asp Ala Trp Trp Ala Glu Ile
385                 390                 395                 400 
Arg Gln Glu Ile Lys Ser His Ala Lys Ala Leu Gly Cys His Ala Val
                405                 410                 415     
Val Gly Tyr Ser Glu Ser Thr Ser Ile Cys Glu Glu Val Cys Ile Leu
            420                 425                 430         
Ser Ala Ser Gly Thr Ala Ala Val Leu Asn Pro Arg Phe Leu Gln Asp
        435                 440                 445             
Gly Thr Val Glu Gly Cys Leu Glu Gln Arg Leu Glu Glu Asn Leu Pro
    450                 455                 460                 
Thr Arg Cys Gly Phe Cys His Ile Pro Tyr Asp Glu Leu Asn Met Pro
465                 470                 475                 480 
Phe Pro Ala His Leu Thr Tyr Cys Tyr Asn Cys Arg Lys Gln Lys Val
                485                 490                 495     
Pro Asp Val Leu Phe Thr Thr Ile Asp Leu Pro Thr Asp Ala Thr Val
            500                 505                 510         
Ile Gly Lys Gly Cys Leu Ile Gln Ala Arg Leu Cys Arg Leu Lys Lys
        515                 520                 525             
Lys Ala Gln Ala Glu Ala Asn Ala Thr Ala Ile Ser Asn Leu Leu Pro
    530                 535                 540                 
Phe Met Glu Tyr Glu Val His Thr Gln Leu Met Asn Lys Leu Lys Leu
545                 550                 555                 560 
Lys Gly Met Asn Ala Leu Phe Gly Leu Arg Ile Gln Ile Thr Val Gly
                565                 570                 575     
Glu Asn Met Leu Met Gly Leu Ala Ser Ala Thr Gly Val Tyr Leu Ala
            580                 585                 590         
Ala Leu Pro Thr Pro Gly Gly Ile Gln Ile Ala Gly Lys Thr Pro Asn
        595                 600                 605             
Asp Gly Ser Tyr Glu Gln His Ile Ser His Met Gln Lys Lys Ile Asn
    610                 615                 620                 
Asp Thr Ile Ala Lys Asn Lys Glu Leu Tyr Glu Ile Asn Pro Pro Glu
625                 630                 635                 640 
Ile Ser Glu Glu Ile Ile Gly Ser Pro Ile Pro Glu Pro Arg Gln Arg
                645                 650                 655     
Ser Arg Leu Leu Arg Ser Gln Ser Glu Ser Ser Asp Glu Val Thr Glu
            660                 665                 670         
Leu Asp Leu Ser His Gly Lys Lys Asp Ala Phe Val Leu Glu Ile Asp
        675                 680                 685             
Asp Thr Asp Ala Met Glu Asp Val His Ser Leu Leu Thr Asp Val Pro
    690                 695                 700                 
Pro Pro Ser Gly Phe Tyr Ser Cys Asn Thr Glu Ile Met Pro Gly Ile
705                 710                 715                 720 
Asn Asn Trp Thr Ser Glu Ile Gln Met Phe Thr Ser Val Arg Val Ile
                725                 730                 735     
Arg Leu Ser Ser Leu Asn Leu Thr Asn Gln Ala Leu Asn Lys Asn Phe
            740                 745                 750         
Asn Asp Leu Cys Glu Asn Leu Leu Lys Ser Leu Tyr Phe Lys Leu Arg
        755                 760                 765             
Ser Met Ile Pro Cys Cys Leu Cys His Val Asn Phe Thr Val Ser Leu
    770                 775                 780                 
Pro Glu Asp Glu Leu Ile Gln Val Thr Val Thr Ala Val Ala Ile Thr
785                 790                 795                 800 
Phe Asp Lys Asn Gln Ala Leu Gln Thr Thr Lys Thr Pro Val Glu Lys
                805                 810                 815     
Ser Leu Gln Arg Ala Ser Thr Asp Asn Glu Glu Leu Leu Gln Phe Pro
            820                 825                 830         
Leu Glu Leu Cys Ser Asp Ser Leu Pro Ser His Pro Phe Pro Pro Ala
        835                 840                 845             
Lys Ala Met Thr Val Glu Lys Ala Ser Pro Val Gly Asp Gly Asn Phe
    850                 855                 860                 
Arg Asn Arg Ser Ala Pro Pro Cys Ala Asn Ser Thr Val Gly Val Val
865                 870                 875                 880 
Lys Met Thr Pro Leu Ser Phe Ile Pro Gly Ala Lys Ile Thr Lys Tyr
                885                 890                 895     
Leu Gly Ile Ile Asn Met Phe Phe Ile Arg Glu Thr Thr Ser Leu Arg
            900                 905                 910         
Glu Glu Gly Gly Val Ser Gly Phe Leu His Ala Phe Ile Ala Glu Val
        915                 920                 925             
Phe Ala Met Val Arg Ala His Val Ala Ala Leu Gly Gly Asn Ala Val
    930                 935                 940                 
Val Ser Tyr Ile Met Lys Gln Cys Val Phe Met Glu Asn Pro Asn Lys
945                 950                 955                 960 
Asn Gln Ala Gln Cys Leu Ile Asn Val Ser Gly Asp Ala Val Val Phe
                965                 970                 975     
Val Arg Glu Ser Asp Leu Glu Val Val Ser Ser Gln Gln Pro Thr Thr
            980                 985                 990         
Asn Cys Gln Ser Ser Cys Thr Glu Gly Glu Val Thr Thr
        995                 1000                1005


<210> 8459
<211> 2644
<212> PRT
<213> Homo sapiens

<400> 8459
Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg
 1               5                  10                  15      
Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys
            20                  25                  30          
Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val
        35                  40                  45              
Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr
    50                  55                  60                  
Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro
65                  70                  75                  80  
Leu Met Phe Val Asn Val Ser Gly Ser His Glu Arg Lys Gly Ser Cys
                85                  90                  95      
Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala
            100                 105                 110         
Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys
        115                 120                 125             
Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val
    130                 135                 140                 
Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His
145                 150                 155                 160 
Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser
                165                 170                 175     
Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala
            180                 185                 190         
Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr
        195                 200                 205             
Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg
    210                 215                 220                 
Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly
225                 230                 235                 240 
Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe
                245                 250                 255     
Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser
            260                 265                 270         
Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu
        275                 280                 285             
Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro
    290                 295                 300                 
Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met
305                 310                 315                 320 
Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg
                325                 330                 335     
Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr
            340                 345                 350         
Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg
        355                 360                 365             
Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly
    370                 375                 380                 
Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu
385                 390                 395                 400 
Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln
                405                 410                 415     
Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg
            420                 425                 430         
Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr
        435                 440                 445             
Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser
    450                 455                 460                 
Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser
465                 470                 475                 480 
Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val
                485                 490                 495     
Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met
            500                 505                 510         
Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro
        515                 520                 525             
Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu
    530                 535                 540                 
Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu
545                 550                 555                 560 
Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met
                565                 570                 575     
Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly
            580                 585                 590         
Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu
        595                 600                 605             
Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile
    610                 615                 620                 
Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu
625                 630                 635                 640 
Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr
                645                 650                 655     
Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val
            660                 665                 670         
Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val
        675                 680                 685             
Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys
    690                 695                 700                 
Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly
705                 710                 715                 720 
Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly
                725                 730                 735     
His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu
            740                 745                 750         
Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe
        755                 760                 765             
Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp
    770                 775                 780                 
Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr
785                 790                 795                 800 
Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro
                805                 810                 815     
Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu
            820                 825                 830         
Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu
        835                 840                 845             
Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu
    850                 855                 860                 
Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala
865                 870                 875                 880 
Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu
                885                 890                 895     
Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg
            900                 905                 910         
Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln
        915                 920                 925             
Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser
    930                 935                 940                 
Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg
945                 950                 955                 960 
Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser
                965                 970                 975     
Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr
            980                 985                 990         
Arg Thr Leu Gln Val Leu Leu Pro Asp Leu Ala Ala Lys Ala Ser Pro
        995                 1000                1005            
Ala Ala Ser Ala Leu Ile Arg Thr Leu Gly Lys Gln Leu Asn Val Asn
    1010                1015                1020                
Arg Arg Glu Ile Leu Ile Asn Asn Phe Lys Tyr Ile Phe Ser His Leu
1025                1030                1035                1040
Val Cys Ser Cys Ser Lys Asp Glu Leu Glu Arg Ala Leu His Tyr Leu
                1045                1050                1055    
Lys Asn Glu Thr Glu Ile Glu Leu Gly Ser Leu Leu Arg Gln Asp Phe
            1060                1065                1070        
Gln Gly Leu His Asn Glu Leu Leu Leu Arg Ile Gly Glu His Tyr Gln
        1075                1080                1085            
Gln Val Phe Asn Gly Leu Ser Ile Leu Ala Ser Phe Ala Ser Ser Asp
    1090                1095                1100                
Asp Pro Tyr Gln Gly Pro Arg Asp Ile Ile Ser Pro Glu Leu Met Ala
1105                1110                1115                1120
Asp Tyr Leu Gln Pro Lys Leu Leu Gly Ile Leu Ala Phe Phe Asn Met
                1125                1130                1135    
Gln Leu Leu Ser Ser Ser Val Gly Ile Glu Asp Lys Lys Met Ala Leu
            1140                1145                1150        
Asn Ser Leu Met Ser Leu Met Lys Leu Met Gly Pro Lys His Val Ser
        1155                1160                1165            
Ser Val Arg Val Lys Met Met Thr Thr Leu Arg Thr Gly Leu Arg Phe
    1170                1175                1180                
Lys Asp Asp Phe Pro Glu Leu Cys Cys Arg Ala Trp Asp Cys Phe Val
1185                1190                1195                1200
Arg Cys Leu Asp His Ala Cys Leu Gly Ser Leu Leu Ser His Val Ile
                1205                1210                1215    
Val Ala Leu Leu Pro Leu Ile His Ile Gln Pro Lys Glu Thr Ala Ala
            1220                1225                1230        
Ile Phe His Tyr Leu Ile Ile Glu Asn Arg Asp Ala Val Gln Asp Phe
        1235                1240                1245            
Leu His Glu Ile Tyr Phe Leu Pro Asp His Pro Glu Leu Lys Lys Ile
    1250                1255                1260                
Lys Ala Val Leu Gln Glu Tyr Arg Lys Glu Thr Ser Glu Ser Thr Asp
1265                1270                1275                1280
Leu Gln Thr Thr Leu Gln Leu Ser Met Lys Ala Ile Gln His Glu Asn
                1285                1290                1295    
Val Asp Val Arg Ile His Ala Leu Thr Ser Leu Lys Glu Thr Leu Tyr
            1300                1305                1310        
Lys Asn Gln Glu Lys Leu Ile Lys Tyr Ala Thr Asp Ser Glu Thr Val
        1315                1320                1325            
Glu Pro Ile Ile Ser Gln Leu Val Thr Val Leu Leu Lys Gly Cys Gln
    1330                1335                1340                
Asp Ala Asn Ser Gln Ala Arg Leu Leu Cys Gly Glu Cys Leu Gly Glu
1345                1350                1355                1360
Leu Gly Ala Ile Asp Pro Gly Arg Leu Asp Phe Ser Thr Thr Glu Thr
                1365                1370                1375    
Gln Gly Lys Asp Phe Thr Phe Val Thr Gly Val Glu Asp Ser Ser Phe
            1380                1385                1390        
Ala Tyr Gly Leu Leu Met Glu Leu Thr Arg Ala Tyr Leu Ala Tyr Ala
        1395                1400                1405            
Asp Asn Ser Arg Ala Gln Asp Ser Ala Ala Tyr Ala Ile Gln Glu Leu
    1410                1415                1420                
Leu Ser Ile Tyr Asp Cys Arg Glu Met Glu Thr Asn Gly Pro Gly His
1425                1430                1435                1440
Gln Leu Trp Arg Arg Phe Pro Glu His Val Arg Glu Ile Leu Glu Pro
                1445                1450                1455    
His Leu Asn Thr Arg Tyr Lys Ser Ser Gln Lys Ser Thr Asp Trp Ser
            1460                1465                1470        
Gly Val Lys Lys Pro Ile Tyr Leu Ser Lys Leu Gly Ser Asn Phe Ala
        1475                1480                1485            
Glu Trp Ser Ala Ser Trp Ala Gly Tyr Leu Ile Thr Lys Val Arg His
    1490                1495                1500                
Asp Leu Ala Ser Lys Ile Phe Thr Cys Cys Ser Ile Met Met Lys His
1505                1510                1515                1520
Asp Phe Lys Val Thr Ile Tyr Leu Leu Pro His Ile Leu Val Tyr Val
                1525                1530                1535    
Leu Leu Gly Cys Asn Gln Glu Asp Gln Gln Glu Val Tyr Ala Glu Ile
            1540                1545                1550        
Met Ala Val Leu Lys His Asp Asp Gln His Thr Ile Asn Thr Gln Asp
        1555                1560                1565            
Ile Ala Ser Asp Leu Cys Gln Leu Ser Thr Gln Thr Val Phe Ser Met
    1570                1575                1580                
Leu Asp His Leu Thr Gln Trp Ala Arg His Lys Phe Gln Ala Leu Lys
1585                1590                1595                1600
Ala Glu Lys Cys Pro His Ser Lys Ser Asn Arg Asn Lys Val Asp Ser
                1605                1610                1615    
Met Val Ser Thr Val Asp Tyr Glu Asp Tyr Gln Ser Val Thr Arg Phe
            1620                1625                1630        
Leu Asp Leu Ile Pro Gln Asp Thr Leu Ala Val Ala Ser Phe Arg Ser
        1635                1640                1645            
Lys Ala Tyr Thr Arg Ala Val Met His Phe Glu Ser Phe Ile Thr Glu
    1650                1655                1660                
Lys Lys Gln Asn Ile Gln Glu His Leu Gly Phe Leu Gln Lys Leu Tyr
1665                1670                1675                1680
Ala Ala Met His Glu Pro Asp Gly Val Ala Gly Val Ser Ala Ile Arg
                1685                1690                1695    
Lys Ala Glu Pro Ser Leu Lys Glu Gln Ile Leu Glu His Glu Ser Leu
            1700                1705                1710        
Gly Leu Leu Arg Asp Ala Thr Ala Cys Tyr Asp Arg Ala Ile Gln Leu
        1715                1720                1725            
Glu Pro Asp Gln Ile Ile His Tyr His Gly Val Val Lys Ser Met Leu
    1730                1735                1740                
Gly Leu Gly Gln Leu Ser Thr Val Ile Thr Gln Val Asn Gly Val His
1745                1750                1755                1760
Ala Asn Arg Ser Glu Trp Thr Asp Glu Leu Asn Thr Tyr Arg Val Glu
                1765                1770                1775    
Ala Ala Trp Lys Leu Ser Gln Trp Asp Leu Val Glu Asn Tyr Leu Ala
            1780                1785                1790        
Ala Asp Gly Lys Ser Thr Thr Trp Ser Val Arg Leu Gly Gln Leu Leu
        1795                1800                1805            
Leu Ser Ala Lys Lys Arg Asp Ile Thr Ala Phe Tyr Asp Ser Leu Lys
    1810                1815                1820                
Leu Val Arg Ala Glu Gln Ile Val Pro Leu Ser Ala Ala Ser Phe Glu
1825                1830                1835                1840
Arg Gly Ser Tyr Gln Arg Gly Tyr Glu Tyr Ile Val Arg Leu His Met
                1845                1850                1855    
Leu Cys Glu Leu Glu His Ser Ile Lys Pro Leu Phe Gln His Ser Pro
            1860                1865                1870        
Gly Asp Ser Ser Gln Glu Asp Ser Leu Asn Trp Val Ala Arg Leu Glu
        1875                1880                1885            
Met Thr Gln Asn Ser Tyr Arg Ala Lys Glu Pro Ile Leu Ala Leu Arg
    1890                1895                1900                
Arg Ala Leu Leu Ser Leu Asn Lys Arg Pro Asp Tyr Asn Glu Met Val
1905                1910                1915                1920
Gly Glu Cys Trp Leu Gln Ser Ala Arg Val Ala Arg Lys Ala Gly His
                1925                1930                1935    
His Gln Thr Ala Tyr Asn Ala Leu Leu Asn Ala Gly Glu Ser Arg Leu
            1940                1945                1950        
Ala Glu Leu Tyr Val Glu Arg Ala Lys Trp Leu Trp Ser Lys Gly Asp
        1955                1960                1965            
Val His Gln Ala Leu Ile Val Leu Gln Lys Gly Val Glu Leu Cys Phe
    1970                1975                1980                
Pro Glu Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu Ile His Gly
1985                1990                1995                2000
Arg Ala Met Leu Leu Val Gly Arg Phe Met Glu Glu Thr Ala Asn Phe
                2005                2010                2015    
Glu Ser Asn Ala Ile Met Lys Lys Tyr Lys Asp Val Thr Ala Cys Leu
            2020                2025                2030        
Pro Glu Trp Glu Asp Gly His Phe Tyr Leu Ala Lys Tyr Tyr Asp Lys
        2035                2040                2045            
Leu Met Pro Met Val Thr Asp Asn Lys Met Glu Lys Gln Gly Asp Leu
    2050                2055                2060                
Ile Arg Tyr Ile Val Leu His Phe Gly Arg Ser Leu Gln Tyr Gly Asn
2065                2070                2075                2080
Gln Phe Ile Tyr Gln Ser Met Pro Arg Met Leu Thr Leu Trp Leu Asp
                2085                2090                2095    
Tyr Gly Thr Lys Ala Tyr Glu Trp Glu Lys Ala Gly Arg Ser Asp Arg
            2100                2105                2110        
Val Gln Met Arg Asn Asp Leu Gly Lys Ile Asn Lys Val Ile Thr Glu
        2115                2120                2125            
His Thr Asn Tyr Leu Ala Pro Tyr Gln Phe Leu Thr Ala Phe Ser Gln
    2130                2135                2140                
Leu Ile Ser Arg Ile Cys His Ser His Asp Glu Val Phe Val Val Leu
2145                2150                2155                2160
Met Glu Ile Ile Ala Lys Val Phe Leu Ala Tyr Pro Gln Gln Ala Met
                2165                2170                2175    
Trp Met Met Thr Ala Val Ser Lys Ser Ser Tyr Pro Met Arg Val Asn
            2180                2185                2190        
Arg Cys Lys Glu Ile Leu Asn Lys Ala Ile His Met Lys Lys Ser Leu
        2195                2200                2205            
Glu Lys Phe Val Gly Asp Ala Thr Arg Leu Thr Asp Lys Leu Leu Glu
    2210                2215                2220                
Leu Cys Asn Lys Pro Val Asp Gly Ser Ser Ser Thr Leu Ser Met Ser
2225                2230                2235                2240
Thr His Phe Lys Met Leu Lys Lys Leu Val Glu Glu Ala Thr Phe Ser
                2245                2250                2255    
Glu Ile Leu Ile Pro Leu Gln Ser Val Met Ile Pro Thr Leu Pro Ser
            2260                2265                2270        
Ile Leu Gly Thr His Ala Asn His Ala Ser His Glu Pro Phe Pro Gly
        2275                2280                2285            
His Trp Ala Tyr Ile Ala Gly Phe Asp Asp Met Val Glu Ile Leu Ala
    2290                2295                2300                
Ser Leu Gln Lys Pro Lys Lys Ile Ser Leu Lys Gly Ser Asp Gly Lys
2305                2310                2315                2320
Phe Tyr Ile Met Met Cys Lys Pro Lys Asp Asp Leu Arg Lys Asp Cys
                2325                2330                2335    
Arg Leu Met Glu Phe Asn Ser Leu Ile Asn Lys Cys Leu Arg Lys Asp
            2340                2345                2350        
Ala Glu Ser Arg Arg Arg Glu Leu His Ile Arg Thr Tyr Ala Val Ile
        2355                2360                2365            
Pro Leu Asn Asp Glu Cys Gly Ile Ile Glu Trp Val Asn Asn Thr Ala
    2370                2375                2380                
Gly Leu Arg Pro Ile Leu Thr Lys Leu Tyr Lys Glu Lys Gly Val Tyr
2385                2390                2395                2400
Met Thr Gly Lys Glu Leu Arg Gln Cys Met Leu Pro Lys Ser Ala Ala
                2405                2410                2415    
Leu Ser Glu Lys Leu Lys Val Phe Arg Glu Phe Leu Leu Pro Arg His
            2420                2425                2430        
Pro Pro Ile Phe His Glu Trp Phe Leu Arg Thr Phe Pro Asp Pro Thr
        2435                2440                2445            
Ser Trp Tyr Ser Ser Arg Ser Ala Tyr Cys Arg Ser Thr Ala Val Met
    2450                2455                2460                
Ser Met Val Gly Tyr Ile Leu Gly Leu Gly Asp Arg His Gly Glu Asn
2465                2470                2475                2480
Ile Leu Phe Asp Ser Leu Thr Gly Glu Cys Val His Val Asp Phe Asn
                2485                2490                2495    
Cys Leu Phe Asn Lys Gly Glu Thr Phe Glu Val Pro Glu Ile Val Pro
            2500                2505                2510        
Phe Arg Leu Thr His Asn Met Val Asn Gly Met Gly Pro Met Gly Thr
        2515                2520                2525            
Glu Gly Leu Phe Arg Arg Ala Cys Glu Val Thr Met Arg Leu Met Arg
    2530                2535                2540                
Asp Gln Arg Glu Pro Leu Met Ser Val Leu Lys Thr Phe Leu His Asp
2545                2550                2555                2560
Pro Leu Val Glu Trp Ser Lys Pro Val Lys Gly His Ser Lys Ala Pro
                2565                2570                2575    
Leu Asn Glu Thr Gly Glu Val Val Asn Glu Lys Ala Lys Thr His Val
            2580                2585                2590        
Leu Asp Ile Glu Gln Arg Leu Gln Gly Val Ile Lys Thr Arg Asn Arg
        2595                2600                2605            
Val Thr Gly Leu Pro Leu Ser Ile Glu Gly His Val His Tyr Leu Ile
    2610                2615                2620                
Gln Glu Ala Thr Asp Glu Asn Leu Leu Cys Gln Met Tyr Leu Gly Trp
2625                2630                2635                2640
Thr Pro Tyr Met
                


<210> 8460
<211> 1032
<212> PRT
<213> Homo sapiens

<400> 8460
Met Ala Glu Thr Asn Asn Glu Cys Ser Ile Lys Val Leu Cys Arg Phe
 1               5                  10                  15      
Arg Pro Leu Asn Gln Ala Glu Ile Leu Arg Gly Asp Lys Phe Ile Pro
            20                  25                  30          
Ile Phe Gln Gly Asp Asp Ser Val Val Ile Gly Gly Lys Pro Tyr Val
        35                  40                  45              
Phe Asp Arg Val Phe Pro Pro Asn Thr Thr Gln Glu Gln Val Tyr His
    50                  55                  60                  
Ala Cys Ala Met Gln Ile Val Lys Asp Val Leu Ala Gly Tyr Asn Gly
65                  70                  75                  80  
Thr Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met
                85                  90                  95      
Glu Gly Lys Leu His Asp Pro Gln Leu Met Gly Ile Ile Pro Arg Ile
            100                 105                 110         
Ala Arg Asp Ile Phe Asn His Ile Tyr Ser Met Asp Glu Asn Leu Glu
        115                 120                 125             
Phe His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg
    130                 135                 140                 
Asp Leu Leu Asp Val Thr Lys Thr Asn Leu Ser Val His Glu Asp Lys
145                 150                 155                 160 
Asn Arg Val Pro Phe Val Lys Gly Cys Thr Glu Arg Phe Val Ser Ser
                165                 170                 175     
Pro Glu Glu Ile Leu Asp Val Ile Asp Glu Gly Lys Ser Asn Arg His
            180                 185                 190         
Val Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile
        195                 200                 205             
Phe Leu Ile Asn Ile Lys Gln Glu Asn Met Glu Thr Glu Gln Lys Leu
    210                 215                 220                 
Ser Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser
225                 230                 235                 240 
Lys Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn
                245                 250                 255     
Lys Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly
            260                 265                 270         
Thr Lys Ser Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu
        275                 280                 285             
Gln Asp Ser Leu Gly Gly Asn Cys Arg Thr Thr Met Phe Ile Cys Cys
    290                 295                 300                 
Ser Pro Ser Ser Tyr Asn Asp Ala Glu Thr Lys Ser Thr Leu Met Phe
305                 310                 315                 320 
Gly Gln Arg Ala Lys Thr Ile Lys Asn Thr Ala Ser Val Asn Leu Glu
                325                 330                 335     
Leu Thr Ala Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys
            340                 345                 350         
Thr Lys Ala Gln Lys Glu Thr Ile Ala Lys Leu Glu Ala Glu Leu Ser
        355                 360                 365             
Arg Trp Arg Asn Gly Glu Asn Val Pro Glu Thr Glu Arg Leu Ala Gly
    370                 375                 380                 
Glu Glu Ala Ala Leu Gly Ala Glu Leu Cys Glu Glu Thr Pro Val Asn
385                 390                 395                 400 
Asp Asn Ser Ser Ile Val Val Arg Ile Ala Pro Glu Glu Arg Gln Lys
                405                 410                 415     
Tyr Glu Glu Glu Ile Arg Arg Leu Tyr Lys Gln Leu Asp Asp Lys Asp
            420                 425                 430         
Asp Glu Ile Asn Gln Gln Ser Gln Leu Ile Glu Lys Leu Lys Gln Gln
        435                 440                 445             
Met Leu Asp Gln Glu Glu Leu Leu Val Ser Thr Arg Gly Asp Asn Glu
    450                 455                 460                 
Lys Val Gln Arg Glu Leu Ser His Leu Gln Ser Glu Asn Asp Ala Ala
465                 470                 475                 480 
Lys Asp Glu Val Lys Glu Val Leu Gln Ala Leu Glu Glu Leu Ala Val
                485                 490                 495     
Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Glu Lys Ser Gln Gln Asn
            500                 505                 510         
Gln Leu Leu Val Asp Glu Leu Ser Gln Lys Val Ala Thr Met Leu Ser
        515                 520                 525             
Leu Glu Ser Glu Leu Gln Arg Leu Gln Glu Val Ser Gly His Gln Arg
    530                 535                 540                 
Lys Arg Ile Ala Glu Val Leu Asn Gly Leu Met Lys Asp Leu Ser Glu
545                 550                 555                 560 
Phe Ser Val Ile Val Gly Asn Gly Glu Ile Lys Leu Pro Val Glu Ile
                565                 570                 575     
Ser Gly Ala Ile Glu Glu Glu Phe Thr Val Ala Arg Leu Tyr Ile Ser
            580                 585                 590         
Lys Ile Lys Ser Glu Val Lys Ser Val Val Lys Arg Cys Arg Gln Leu
        595                 600                 605             
Glu Asn Leu Gln Val Glu Cys His Arg Lys Met Glu Val Thr Gly Arg
    610                 615                 620                 
Glu Leu Ser Ser Cys Gln Leu Leu Ile Ser Gln His Glu Ala Lys Ile
625                 630                 635                 640 
Arg Ser Leu Thr Glu Tyr Met Gln Ser Val Glu Leu Lys Lys Arg His
                645                 650                 655     
Leu Glu Glu Ser Tyr Asp Ser Leu Ser Asp Glu Leu Ala Lys Leu Gln
            660                 665                 670         
Ala Gln Glu Thr Val His Glu Val Ala Leu Lys Asp Lys Glu Pro Asp
        675                 680                 685             
Thr Gln Asp Ala Asp Glu Val Lys Lys Ala Leu Glu Leu Gln Met Glu
    690                 695                 700                 
Ser His Arg Glu Ala His His Arg Gln Leu Ala Arg Leu Arg Asp Glu
705                 710                 715                 720 
Ile Asn Glu Lys Gln Lys Thr Ile Asp Glu Leu Lys Asp Leu Asn Gln
                725                 730                 735     
Lys Leu Gln Leu Glu Leu Glu Lys Leu Gln Ala Asp Tyr Glu Lys Leu
            740                 745                 750         
Lys Ser Glu Glu His Glu Lys Ser Thr Lys Leu Gln Glu Leu Thr Phe
        755                 760                 765             
Leu Tyr Glu Arg His Glu Gln Ser Lys Gln Asp Leu Lys Gly Leu Glu
    770                 775                 780                 
Glu Thr Val Ala Arg Glu Leu Gln Thr Leu His Asn Leu Arg Lys Leu
785                 790                 795                 800 
Phe Val Gln Asp Val Thr Thr Arg Val Lys Lys Ser Ala Glu Met Glu
                805                 810                 815     
Pro Glu Asp Ser Gly Gly Ile His Ser Gln Lys Gln Lys Ile Ser Phe
            820                 825                 830         
Leu Glu Asn Asn Leu Glu Gln Leu Thr Lys Val His Lys Gln Leu Val
        835                 840                 845             
Arg Asp Asn Ala Asp Leu Arg Cys Glu Leu Pro Lys Leu Glu Lys Arg
    850                 855                 860                 
Leu Arg Ala Thr Ala Glu Arg Val Lys Ala Leu Glu Gly Ala Leu Lys
865                 870                 875                 880 
Glu Ala Lys Glu Gly Ala Met Lys Asp Lys Arg Arg Tyr Gln Gln Glu
                885                 890                 895     
Val Asp Arg Ile Lys Glu Ala Val Arg Tyr Lys Ser Ser Gly Lys Arg
            900                 905                 910         
Ala His Ser Ala Gln Ile Ala Lys Pro Val Arg Pro Gly His Tyr Pro
        915                 920                 925             
Ala Ser Ser Pro Thr Asn Pro Tyr Gly Thr Arg Ser Pro Glu Cys Ile
    930                 935                 940                 
Ser Tyr Thr Asn Ser Leu Phe Gln Asn Tyr Gln Asn Leu Tyr Leu Gln
945                 950                 955                 960 
Ala Thr Pro Ser Ser Thr Ser Asp Met Tyr Phe Ala Asn Ser Cys Thr
                965                 970                 975     
Ser Ser Gly Ala Thr Ser Ser Gly Gly Pro Leu Ala Ser Tyr Gln Lys
            980                 985                 990         
Ala Asn Met Asp Asn Gly Asn Ala Thr Asp Ile Asn Asp Asn Arg Ser
        995                 1000                1005            
Asp Leu Pro Cys Gly Tyr Glu Ala Glu Asp Gln Ala Lys Leu Phe Pro
    1010                1015                1020                
Leu His Gln Glu Thr Ala Ala Ser
1025                1030        


<210> 8461
<211> 837
<212> PRT
<213> Homo sapiens

<400> 8461
Met Ala Ala Pro Gly Ala Pro Ala Glu Tyr Gly Tyr Ile Arg Thr Val
 1               5                  10                  15      
Leu Gly Gln Gln Ile Leu Gly Gln Leu Asp Ser Ser Ser Leu Ala Leu
            20                  25                  30          
Pro Ser Glu Ala Lys Leu Lys Leu Ala Gly Ser Ser Gly Arg Gly Gly
        35                  40                  45              
Gln Thr Val Lys Ser Leu Arg Ile Gln Glu Gln Val Gln Gln Thr Leu
    50                  55                  60                  
Ala Arg Lys Gly Arg Ser Ser Val Gly Asn Gly Asn Leu His Arg Thr
65                  70                  75                  80  
Ser Ser Val Pro Glu Tyr Val Tyr Asn Leu His Leu Val Glu Asn Asp
                85                  90                  95      
Phe Val Gly Gly Arg Ser Pro Val Pro Lys Thr Tyr Asp Met Leu Lys
            100                 105                 110         
Ala Gly Thr Thr Ala Thr Tyr Glu Gly Arg Trp Gly Arg Gly Thr Ala
        115                 120                 125             
Gln Tyr Ser Ser Gln Lys Ser Val Glu Glu Arg Ser Leu Arg His Pro
    130                 135                 140                 
Leu Arg Arg Leu Glu Ile Ser Pro Asp Ser Ser Pro Glu Arg Ala His
145                 150                 155                 160 
Tyr Thr His Ser Asp Tyr Gln Tyr Ser Gln Arg Ser Gln Ala Gly His
                165                 170                 175     
Thr Leu His His Gln Glu Ser Arg Arg Ala Ala Leu Leu Val Pro Pro
            180                 185                 190         
Arg Tyr Ala Arg Ser Glu Ile Val Gly Val Ser Arg Ala Gly Thr Thr
        195                 200                 205             
Ser Arg Gln Arg His Phe Asp Thr Tyr His Arg Gln Tyr Gln His Gly
    210                 215                 220                 
Ser Val Ser Asp Thr Val Phe Asp Ser Ile Pro Ala Asn Pro Ala Leu
225                 230                 235                 240 
Leu Thr Tyr Pro Arg Pro Gly Thr Ser Arg Ser Met Gly Asn Leu Leu
                245                 250                 255     
Glu Lys Glu Asn Tyr Leu Thr Ala Gly Leu Thr Val Gly Gln Val Arg
            260                 265                 270         
Pro Leu Val Pro Leu Gln Pro Val Thr Gln Asn Arg Ala Ser Arg Ser
        275                 280                 285             
Ser Trp His Gln Ser Ser Phe His Ser Thr Arg Thr Leu Arg Glu Ala
    290                 295                 300                 
Gly Pro Ser Val Ala Val Asp Ser Ser Gly Arg Arg Ala His Leu Thr
305                 310                 315                 320 
Val Gly Gln Ala Ala Ala Gly Gly Ser Gly Asn Leu Leu Thr Glu Arg
                325                 330                 335     
Ser Thr Phe Thr Asp Ser Gln Leu Gly Asn Ala Asp Met Glu Met Thr
            340                 345                 350         
Leu Glu Arg Ala Val Ser Met Leu Glu Ala Asp His Met Pro Pro Ser
        355                 360                 365             
Arg Ile Ser Ala Ala Ala Thr Phe Ile Gln His Glu Cys Phe Gln Lys
    370                 375                 380                 
Ser Glu Ala Arg Lys Arg Val Asn Gln Leu Arg Gly Ile Leu Lys Leu
385                 390                 395                 400 
Leu Gln Leu Leu Lys Val Gln Asn Glu Asp Val Gln Arg Ala Val Cys
                405                 410                 415     
Gly Ala Leu Arg Asn Leu Val Phe Glu Asp Asn Asp Asn Lys Leu Glu
            420                 425                 430         
Val Ala Glu Leu Asn Gly Val Pro Arg Leu Leu Gln Val Leu Lys Gln
        435                 440                 445             
Thr Arg Asp Leu Glu Thr Lys Lys Gln Ile Thr Gly Leu Leu Trp Asn
    450                 455                 460                 
Leu Ser Ser Asn Asp Lys Leu Lys Asn Leu Met Ile Thr Glu Ala Leu
465                 470                 475                 480 
Leu Thr Leu Thr Glu Asn Ile Ile Ile Pro Phe Ser Gly Trp Pro Glu
                485                 490                 495     
Gly Asp Tyr Pro Lys Ala Asn Gly Leu Leu Asp Phe Asp Ile Phe Tyr
            500                 505                 510         
Asn Val Thr Gly Cys Leu Arg Asn Met Ser Ser Ala Gly Ala Asp Gly
        515                 520                 525             
Arg Lys Ala Met Arg Arg Cys Asp Gly Leu Ile Asp Ser Leu Val His
    530                 535                 540                 
Tyr Val Arg Gly Thr Ile Ala Asp Tyr Gln Pro Asp Asp Lys Ala Thr
545                 550                 555                 560 
Glu Asn Cys Val Cys Ile Leu His Asn Leu Ser Tyr Gln Leu Glu Ala
                565                 570                 575     
Glu Leu Pro Glu Lys Tyr Ser Gln Asn Ile Tyr Ile Gln Asn Arg Asn
            580                 585                 590         
Ile Gln Thr Asp Asn Asn Lys Ser Ile Gly Cys Phe Gly Ser Arg Ser
        595                 600                 605             
Arg Lys Val Lys Glu Gln Tyr Gln Asp Val Pro Met Pro Glu Glu Lys
    610                 615                 620                 
Ser Asn Pro Lys Gly Val Glu Trp Leu Trp His Ser Ile Val Ile Arg
625                 630                 635                 640 
Met Tyr Leu Ser Leu Ile Ala Lys Ser Val Arg Asn Tyr Thr Gln Glu
                645                 650                 655     
Ala Ser Leu Gly Ala Leu Gln Asn Leu Thr Ala Gly Ser Gly Pro Met
            660                 665                 670         
Pro Thr Ser Val Ala Gln Thr Val Val Gln Lys Glu Ser Gly Leu Gln
        675                 680                 685             
His Thr Arg Lys Met Leu His Val Gly Asp Pro Ser Val Lys Lys Thr
    690                 695                 700                 
Ala Ile Ser Leu Leu Arg Asn Leu Ser Arg Asn Leu Ser Leu Gln Asn
705                 710                 715                 720 
Glu Ile Ala Lys Glu Thr Leu Pro Asp Leu Val Ser Ile Ile Pro Asp
                725                 730                 735     
Thr Val Pro Ser Thr Asp Leu Leu Ile Glu Thr Thr Ala Ser Ala Cys
            740                 745                 750         
Tyr Thr Leu Asn Asn Ile Ile Gln Asn Ser Tyr Gln Asn Ala Arg Asp
        755                 760                 765             
Leu Leu Asn Thr Gly Gly Ile Gln Lys Ile Met Ala Ile Ser Ala Gly
    770                 775                 780                 
Asp Ala Tyr Ala Ser Asn Lys Ala Ser Lys Ala Ala Ser Val Leu Leu
785                 790                 795                 800 
Tyr Ser Leu Trp Ala His Thr Glu Leu His His Ala Tyr Lys Lys Ala
                805                 810                 815     
Gln Phe Lys Lys Thr Asp Phe Val Asn Ser Arg Thr Ala Lys Ala Tyr
            820                 825                 830         
His Ser Leu Lys Asp
        835         


<210> 8462
<211> 881
<212> PRT
<213> Homo sapiens

<400> 8462
Met Ala Ala Pro Gly Ala Pro Ala Glu Tyr Gly Tyr Ile Arg Thr Val
 1               5                  10                  15      
Leu Gly Gln Gln Ile Leu Gly Gln Leu Asp Ser Ser Ser Leu Ala Leu
            20                  25                  30          
Pro Ser Glu Ala Lys Leu Lys Leu Ala Gly Ser Ser Gly Arg Gly Gly
        35                  40                  45              
Gln Thr Val Lys Ser Leu Arg Ile Gln Glu Gln Val Gln Gln Thr Leu
    50                  55                  60                  
Ala Arg Lys Gly Arg Ser Ser Val Gly Asn Gly Asn Leu His Arg Thr
65                  70                  75                  80  
Ser Ser Val Pro Glu Tyr Val Tyr Asn Leu His Leu Val Glu Asn Asp
                85                  90                  95      
Phe Val Gly Gly Arg Ser Pro Val Pro Lys Thr Tyr Asp Met Leu Lys
            100                 105                 110         
Ala Gly Thr Thr Ala Thr Tyr Glu Gly Arg Trp Gly Arg Gly Thr Ala
        115                 120                 125             
Gln Tyr Ser Ser Gln Lys Ser Val Glu Glu Arg Ser Leu Arg His Pro
    130                 135                 140                 
Leu Arg Arg Leu Glu Ile Ser Pro Asp Ser Ser Pro Glu Arg Ala His
145                 150                 155                 160 
Tyr Thr His Ser Asp Tyr Gln Tyr Ser Gln Arg Ser Gln Ala Gly His
                165                 170                 175     
Thr Leu His His Gln Glu Ser Arg Arg Ala Ala Leu Leu Val Pro Pro
            180                 185                 190         
Arg Tyr Ala Arg Ser Glu Ile Val Gly Val Ser Arg Ala Gly Thr Thr
        195                 200                 205             
Ser Arg Gln Arg His Phe Asp Thr Tyr His Arg Gln Tyr Gln His Gly
    210                 215                 220                 
Ser Val Ser Asp Thr Val Phe Asp Ser Ile Pro Ala Asn Pro Ala Leu
225                 230                 235                 240 
Leu Thr Tyr Pro Arg Pro Gly Thr Ser Arg Ser Met Gly Asn Leu Leu
                245                 250                 255     
Glu Lys Glu Asn Tyr Leu Thr Ala Gly Leu Thr Val Gly Gln Val Arg
            260                 265                 270         
Pro Leu Val Pro Leu Gln Pro Val Thr Gln Asn Arg Ala Ser Arg Ser
        275                 280                 285             
Ser Trp His Gln Ser Ser Phe His Ser Thr Arg Thr Leu Arg Glu Ala
    290                 295                 300                 
Gly Pro Ser Val Ala Val Asp Ser Ser Gly Arg Arg Ala His Leu Thr
305                 310                 315                 320 
Val Gly Gln Ala Ala Ala Gly Gly Ser Gly Asn Leu Leu Thr Glu Arg
                325                 330                 335     
Ser Thr Phe Thr Asp Ser Gln Leu Gly Asn Ala Asp Met Glu Met Thr
            340                 345                 350         
Leu Glu Arg Ala Val Ser Met Leu Glu Ala Asp His Met Pro Pro Ser
        355                 360                 365             
Arg Ile Ser Ala Ala Ala Thr Phe Ile Gln His Glu Cys Phe Gln Lys
    370                 375                 380                 
Ser Glu Ala Arg Lys Arg Val Asn Gln Leu Arg Gly Ile Leu Lys Leu
385                 390                 395                 400 
Leu Gln Leu Leu Lys Val Gln Asn Glu Asp Val Gln Arg Ala Val Cys
                405                 410                 415     
Gly Ala Leu Arg Asn Leu Val Phe Glu Asp Asn Asp Asn Lys Leu Glu
            420                 425                 430         
Val Ala Glu Leu Asn Gly Val Pro Arg Leu Leu Gln Val Leu Lys Gln
        435                 440                 445             
Thr Arg Asp Leu Glu Thr Lys Lys Gln Ile Thr Asp His Thr Val Asn
    450                 455                 460                 
Leu Arg Ser Arg Asn Gly Trp Pro Gly Ala Val Ala His Ala Cys Asn
465                 470                 475                 480 
Pro Ser Thr Leu Gly Gly Gln Gly Gly Arg Ile Thr Arg Ser Gly Val
                485                 490                 495     
Arg Asp Gln Pro Asp Gln His Gly Leu Leu Trp Asn Leu Ser Ser Asn
            500                 505                 510         
Asp Lys Leu Lys Asn Leu Met Ile Thr Glu Ala Leu Leu Thr Leu Thr
        515                 520                 525             
Glu Asn Ile Ile Ile Pro Phe Ser Gly Trp Pro Glu Gly Asp Tyr Pro
    530                 535                 540                 
Lys Ala Asn Gly Leu Leu Asp Phe Asp Ile Phe Tyr Asn Val Thr Gly
545                 550                 555                 560 
Cys Leu Arg Asn Met Ser Ser Ala Gly Ala Asp Gly Arg Lys Ala Met
                565                 570                 575     
Arg Arg Cys Asp Gly Leu Ile Asp Ser Leu Val His Tyr Val Arg Gly
            580                 585                 590         
Thr Ile Ala Asp Tyr Gln Pro Asp Asp Lys Ala Thr Glu Asn Cys Val
        595                 600                 605             
Cys Ile Leu His Asn Leu Ser Tyr Gln Leu Glu Ala Glu Leu Pro Glu
    610                 615                 620                 
Lys Tyr Ser Gln Asn Ile Tyr Ile Gln Asn Arg Asn Ile Gln Thr Asp
625                 630                 635                 640 
Asn Asn Lys Ser Ile Gly Cys Phe Gly Ser Arg Ser Arg Lys Val Lys
                645                 650                 655     
Glu Gln Tyr Gln Asp Val Pro Met Pro Glu Glu Lys Ser Asn Pro Lys
            660                 665                 670         
Gly Val Glu Trp Leu Trp His Ser Ile Val Ile Arg Met Tyr Leu Ser
        675                 680                 685             
Leu Ile Ala Lys Ser Val Arg Asn Tyr Thr Gln Glu Ala Ser Leu Gly
    690                 695                 700                 
Ala Leu Gln Asn Leu Thr Ala Gly Ser Gly Pro Met Pro Thr Ser Val
705                 710                 715                 720 
Ala Gln Thr Val Val Gln Lys Glu Ser Gly Leu Gln His Thr Arg Lys
                725                 730                 735     
Met Leu His Val Gly Asp Pro Ser Val Lys Lys Thr Ala Ile Ser Leu
            740                 745                 750         
Leu Arg Asn Leu Ser Arg Asn Leu Ser Leu Gln Asn Glu Ile Ala Lys
        755                 760                 765             
Glu Thr Leu Pro Asp Leu Val Ser Ile Ile Pro Asp Thr Val Pro Ser
    770                 775                 780                 
Thr Asp Leu Leu Ile Glu Thr Thr Ala Ser Ala Cys Tyr Thr Leu Asn
785                 790                 795                 800 
Asn Ile Ile Gln Asn Ser Tyr Gln Asn Ala Arg Asp Leu Leu Asn Thr
                805                 810                 815     
Gly Gly Ile Gln Lys Ile Met Ala Ile Ser Ala Gly Asp Ala Tyr Ala
            820                 825                 830         
Ser Asn Lys Ala Ser Lys Ala Ala Ser Val Leu Leu Tyr Ser Leu Trp
        835                 840                 845             
Ala His Thr Glu Leu His His Ala Tyr Lys Lys Ala Gln Phe Lys Lys
    850                 855                 860                 
Thr Asp Phe Val Asn Ser Arg Thr Ala Lys Ala Tyr His Ser Leu Lys
865                 870                 875                 880 
Asp
    


<210> 8463
<211> 674
<212> PRT
<213> Homo sapiens

<400> 8463
Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser Gln Trp Phe Ala
 1               5                  10                  15      
Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly Ser Ala Gly Cys
            20                  25                  30          
Ser Glu Lys His Leu Leu Asp Lys Pro Phe Tyr Asn Asp Phe Glu Arg
        35                  40                  45              
Gly Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly Glu
    50                  55                  60                  
Ile Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Trp Leu Asn Asp Asp
65                  70                  75                  80  
Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr Ile
                85                  90                  95      
Glu Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val Leu
            100                 105                 110         
Arg Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile Leu
        115                 120                 125             
Lys Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr Arg
    130                 135                 140                 
Trp Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys Cys
145                 150                 155                 160 
His Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly Val
                165                 170                 175     
Asp Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile Asn
            180                 185                 190         
Arg Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp Phe
        195                 200                 205             
Glu Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val Met
    210                 215                 220                 
Asn His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn Gly
225                 230                 235                 240 
Cys Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys Leu
                245                 250                 255     
Pro Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu Ser
            260                 265                 270         
Leu Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe Glu
        275                 280                 285             
Leu Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu Gln
    290                 295                 300                 
Phe Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn Lys
305                 310                 315                 320 
Ile Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu Asn
                325                 330                 335     
Pro Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala Lys
            340                 345                 350         
Ile Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr His
        355                 360                 365             
Leu Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met Tyr
    370                 375                 380                 
Arg Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala His
385                 390                 395                 400 
Val Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu Ile
                405                 410                 415     
Cys Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly Gly
            420                 425                 430         
His Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala Ser
        435                 440                 445             
Leu Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys Glu
    450                 455                 460                 
Asp Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp Glu
465                 470                 475                 480 
Ala Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu Gly
                485                 490                 495     
Asp Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn Asp
            500                 505                 510         
Val Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro Lys
        515                 520                 525             
Ser Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val Ile
    530                 535                 540                 
Phe Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr Asp
545                 550                 555                 560 
Trp Cys Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro Pro
                565                 570                 575     
Pro Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr Leu
            580                 585                 590         
Pro Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala Leu
        595                 600                 605             
Ser Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu Glu
    610                 615                 620                 
His Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg Lys
625                 630                 635                 640 
Asn Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Lys Lys Lys
                645                 650                 655     
Gln Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val
            660                 665                 670         
Ala Ile
        


<210> 8464
<211> 599
<212> PRT
<213> Homo sapiens

<400> 8464
Met Gln Trp Pro Pro Pro Trp Arg Arg Ser Pro Leu Val Ser Ala Thr
 1               5                  10                  15      
Pro Pro Pro Gly Pro Thr Arg Gly Leu Leu Cys Pro Arg Arg Val Ser
            20                  25                  30          
Glu Ala Gly Asp Ser Ser Thr Glu Gly Ala Arg Thr Gly His Arg His
        35                  40                  45              
Tyr Val Thr Pro Ala Glu Ser Ala Met Glu Gly Arg Ser Gln Pro Leu
    50                  55                  60                  
Pro Ser Leu Arg Pro Ala Ser Pro Thr Asn Ala Pro Ala His Gly Arg
65                  70                  75                  80  
Gly Ser Asp Cys Thr Ala Lys Glu Pro Pro Leu Ala Asn Val Cys Arg
                85                  90                  95      
Gln Asn Tyr Gly Ala Ala Gln Asp Pro Val Glu Pro Ala Gly Arg Arg
            100                 105                 110         
Ser Ala Ser His Val Thr Gly Ser Ser Leu Gly Lys Ala Glu Val Ala
        115                 120                 125             
Cys Gly Arg Arg Trp Arg Trp Ala Glu Leu Leu Ala Asp Thr Ser Trp
    130                 135                 140                 
Ser Pro Ala Gly Arg Ala Thr Glu Met Lys Val Lys Met Leu Ser Arg
145                 150                 155                 160 
Asn Pro Asp Asn Tyr Val Arg Glu Thr Lys Leu Asp Leu Gln Arg Val
                165                 170                 175     
Pro Arg Asn Tyr Asp Pro Ala Leu His Pro Phe Glu Val Pro Arg Glu
            180                 185                 190         
Tyr Ile Arg Ala Leu Asn Ala Thr Lys Leu Glu Arg Val Phe Ala Lys
        195                 200                 205             
Pro Phe Leu Ala Ser Leu Asp Gly His Arg Asp Gly Val Asn Cys Leu
    210                 215                 220                 
Ala Lys His Pro Glu Lys Leu Ala Thr Val Leu Ser Gly Ala Cys Asp
225                 230                 235                 240 
Gly Glu Ala Ser Val Arg Ile Trp Asn Leu Thr Gln Arg Asn Cys Ile
                245                 250                 255     
Arg Thr Ile Gln Ala His Glu Gly Phe Val Arg Gly Ile Cys Thr Arg
            260                 265                 270         
Phe Cys Gly Thr Ser Phe Phe Thr Val Gly Asp Asp Lys Thr Val Lys
        275                 280                 285             
Gln Trp Lys Met Asp Gly Pro Gly Tyr Gly Asp Glu Glu Glu Pro Leu
    290                 295                 300                 
His Thr Ile Leu Gly Lys Thr Val Tyr Thr Gly Ile Asp His His Trp
305                 310                 315                 320 
Lys Glu Ala Val Phe Ala Thr Cys Gly Gln Gln Val Asp Ile Trp Asp
                325                 330                 335     
Glu Gln Arg Thr Asn Pro Ile Cys Ser Met Thr Trp Gly Phe Asp Ser
            340                 345                 350         
Ile Ser Ser Val Lys Phe Asn Pro Ile Glu Thr Phe Leu Leu Gly Ser
        355                 360                 365             
Cys Ala Ser Asp Arg Asn Ile Val Leu Tyr Asp Met Arg Gln Ala Thr
    370                 375                 380                 
Pro Leu Lys Lys Val Ile Leu Asp Met Arg Thr Asn Thr Ile Cys Trp
385                 390                 395                 400 
Asn Pro Met Glu Ala Phe Ile Phe Thr Ala Ala Asn Glu Asp Tyr Asn
                405                 410                 415     
Leu Tyr Thr Phe Asp Met Arg Ala Leu Asp Thr Pro Val Met Val His
            420                 425                 430         
Met Asp His Val Ser Ala Val Leu Asp Val Asp Tyr Ser Pro Thr Gly
        435                 440                 445             
Lys Glu Phe Val Ser Ala Ser Phe Asp Lys Ser Ile Arg Ile Phe Pro
    450                 455                 460                 
Val Asp Lys Ser Arg Ser Arg Glu Val Tyr His Thr Lys Arg Met Gln
465                 470                 475                 480 
His Val Ile Cys Val Lys Trp Thr Ser Asp Ser Lys Tyr Ile Met Cys
                485                 490                 495     
Gly Ser Asp Glu Met Asn Ile Arg Leu Trp Lys Ala Asn Ala Ser Glu
            500                 505                 510         
Lys Leu Gly Val Leu Thr Ser Arg Glu Lys Ala Ala Lys Asp Tyr Asn
        515                 520                 525             
Gln Lys Leu Lys Glu Lys Phe Gln His Tyr Pro His Ile Lys Arg Ile
    530                 535                 540                 
Ala Arg His Arg His Leu Pro Lys Ser Ile Tyr Ser Gln Ile Gln Glu
545                 550                 555                 560 
Gln Arg Ile Met Lys Glu Ala Arg Arg Arg Lys Glu Val Asn Arg Ile
                565                 570                 575     
Lys His Ser Lys Pro Gly Ser Val Pro Leu Val Ser Glu Lys Lys Lys
            580                 585                 590         
His Val Val Ala Val Val Lys
        595                 


<210> 8465
<211> 481
<212> PRT
<213> Homo sapiens

<400> 8465
Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr
 1               5                  10                  15      
Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile
            20                  25                  30          
Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe
        35                  40                  45              
Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn
    50                  55                  60                  
Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp
65                  70                  75                  80  
Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser
                85                  90                  95      
His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser
            100                 105                 110         
Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val
        115                 120                 125             
Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg
    130                 135                 140                 
Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His
145                 150                 155                 160 
Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser
                165                 170                 175     
Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr
            180                 185                 190         
Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys
        195                 200                 205             
Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys
    210                 215                 220                 
Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His
225                 230                 235                 240 
Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg
                245                 250                 255     
Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu
            260                 265                 270         
Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro
        275                 280                 285             
Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys
    290                 295                 300                 
Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val
305                 310                 315                 320 
Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met
                325                 330                 335     
Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly
            340                 345                 350         
Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys
        355                 360                 365             
Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr
    370                 375                 380                 
Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val
385                 390                 395                 400 
Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala
                405                 410                 415     
Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala
            420                 425                 430         
Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser
        435                 440                 445             
Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His
    450                 455                 460                 
Val Arg His Ala Arg Trp Gly Glu Lys Gln Phe Ile His Leu Lys Leu
465                 470                 475                 480 
Ser
    


<210> 8466
<211> 472
<212> PRT
<213> Homo sapiens

<400> 8466
Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr
 1               5                  10                  15      
Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile
            20                  25                  30          
Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe
        35                  40                  45              
Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn
    50                  55                  60                  
Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp
65                  70                  75                  80  
Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser
                85                  90                  95      
His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser
            100                 105                 110         
Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val
        115                 120                 125             
Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg
    130                 135                 140                 
Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His
145                 150                 155                 160 
Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser
                165                 170                 175     
Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr
            180                 185                 190         
Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys
        195                 200                 205             
Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys
    210                 215                 220                 
Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His
225                 230                 235                 240 
Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg
                245                 250                 255     
Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu
            260                 265                 270         
Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro
        275                 280                 285             
Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys
    290                 295                 300                 
Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val
305                 310                 315                 320 
Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met
                325                 330                 335     
Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly
            340                 345                 350         
Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys
        355                 360                 365             
Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr
    370                 375                 380                 
Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val
385                 390                 395                 400 
Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala
                405                 410                 415     
Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala
            420                 425                 430         
Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser
        435                 440                 445             
Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His
    450                 455                 460                 
Val Arg His Ala Arg Tyr Ala Pro
465                 470         


<210> 8467
<211> 495
<212> PRT
<213> Homo sapiens

<400> 8467
Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr
 1               5                  10                  15      
Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile
            20                  25                  30          
Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe
        35                  40                  45              
Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn
    50                  55                  60                  
Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp
65                  70                  75                  80  
Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser
                85                  90                  95      
His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser
            100                 105                 110         
Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val
        115                 120                 125             
Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg
    130                 135                 140                 
Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His
145                 150                 155                 160 
Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser
                165                 170                 175     
Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr
            180                 185                 190         
Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys
        195                 200                 205             
Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys
    210                 215                 220                 
Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His
225                 230                 235                 240 
Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg
                245                 250                 255     
Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu
            260                 265                 270         
Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro
        275                 280                 285             
Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys
    290                 295                 300                 
Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val
305                 310                 315                 320 
Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met
                325                 330                 335     
Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly
            340                 345                 350         
Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys
        355                 360                 365             
Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr
    370                 375                 380                 
Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val
385                 390                 395                 400 
Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala
                405                 410                 415     
Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala
            420                 425                 430         
Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser
        435                 440                 445             
Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His
    450                 455                 460                 
Val Arg His Ala Arg Ala Glu Lys Ala Ser Gln Thr Leu Thr Ser Phe
465                 470                 475                 480 
Gly Met Lys Met Glu Thr Leu Leu Pro Glu Ala Thr Met Glu Gln
                485                 490                 495 


<210> 8468
<211> 513
<212> PRT
<213> Homo sapiens

<400> 8468
Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr
 1               5                  10                  15      
Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile
            20                  25                  30          
Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe
        35                  40                  45              
Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn
    50                  55                  60                  
Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp
65                  70                  75                  80  
Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser
                85                  90                  95      
His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser
            100                 105                 110         
Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val
        115                 120                 125             
Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg
    130                 135                 140                 
Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His
145                 150                 155                 160 
Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser
                165                 170                 175     
Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr
            180                 185                 190         
Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys
        195                 200                 205             
Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys
    210                 215                 220                 
Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His
225                 230                 235                 240 
Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg
                245                 250                 255     
Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu
            260                 265                 270         
Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro
        275                 280                 285             
Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys
    290                 295                 300                 
Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val
305                 310                 315                 320 
Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met
                325                 330                 335     
Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly
            340                 345                 350         
Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys
        355                 360                 365             
Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr
    370                 375                 380                 
Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val
385                 390                 395                 400 
Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala
                405                 410                 415     
Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala
            420                 425                 430         
Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser
        435                 440                 445             
Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His
    450                 455                 460                 
Val Arg His Ala Ser Ser Leu Ser Leu Ser Trp Arg Leu Phe Met Leu
465                 470                 475                 480 
Arg Glu Ala Ser Cys His Gly Val Arg Gln Thr Pro Gly Gly Ala His
                485                 490                 495     
Met Ser Val Ser Arg Ser Arg Ser Phe Glu Ala Cys Gln Gln Pro Arg
            500                 505                 510         
Glu
    


<210> 8469
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8469
Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr
 1               5                  10                  15      
Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile
            20                  25                  30          
Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe
        35                  40                  45              
Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn
    50                  55                  60                  
Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp
65                  70                  75                  80  
Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser
                85                  90                  95      
His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser
            100                 105                 110         
Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val
        115                 120                 125             
Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg
    130                 135                 140                 
Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His
145                 150                 155                 160 
Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser
                165                 170                 175     
Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr
            180                 185                 190         
Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys
        195                 200                 205             
Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys
    210                 215                 220                 
Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His
225                 230                 235                 240 
Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg
                245                 250                 255     
Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu
            260                 265                 270         
Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro
        275                 280                 285             
Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys
    290                 295                 300                 
Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val
305                 310                 315                 320 
Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met
                325                 330                 335     
Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly
            340                 345                 350         
Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys
        355                 360                 365             
Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr
    370                 375                 380                 
Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val
385                 390                 395                 400 
Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala
                405                 410                 415     
Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala
            420                 425                 430         
Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser
        435                 440                 445             
Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His
    450                 455                 460                 
Val Arg His Ala Ser Asn Lys Gly Met Glu His Leu Leu Asn Met Lys
465                 470                 475                 480 
Cys Lys Asn Val Val Pro Val Tyr Asp Leu Leu Leu Glu Met Leu Asn
                485                 490                 495     
Ala His Val Leu Arg Gly Cys Lys Ser Ser Ile Thr Gly Ser Glu Cys
            500                 505                 510         
Ser Pro Ala Glu Asp Ser Lys Ser Lys Glu Gly Ser Gln Asn Pro Gln
        515                 520                 525             
Ser Gln
    530 


<210> 8470
<211> 5184
<212> PRT
<213> Homo sapiens

<400> 8470
Met Ala Thr Ser Gly Gly Glu Glu Ala Ala Ala Ala Ala Pro Ala Pro
 1               5                  10                  15      
Gly Thr Pro Ala Thr Gly Ala Asp Thr Thr Pro Gly Trp Glu Val Ala
            20                  25                  30          
Val Arg Pro Leu Leu Ser Ala Ser Tyr Ser Ala Phe Glu Met Lys Glu
        35                  40                  45              
Leu Pro Gln Leu Val Ala Ser Val Ile Glu Ser Glu Ser Glu Ile Leu
    50                  55                  60                  
His His Glu Lys Gln Tyr Glu Pro Phe Tyr Ser Ser Phe Val Ala Leu
65                  70                  75                  80  
Ser Thr His Tyr Ile Thr Thr Val Cys Ser Leu Ile Pro Arg Asn Gln
                85                  90                  95      
Leu Gln Ser Val Ala Ala Ala Cys Lys Val Leu Ile Glu Phe Ser Leu
            100                 105                 110         
Leu Arg Leu Glu Asn Pro Asp Glu Ala Cys Ala Val Ser Gln Lys His
        115                 120                 125             
Leu Ile Leu Leu Ile Lys Gly Leu Cys Thr Gly Cys Ser Arg Leu Asp
    130                 135                 140                 
Arg Thr Glu Ile Ile Thr Phe Thr Ala Met Met Lys Ser Ala Lys Leu
145                 150                 155                 160 
Pro Gln Thr Val Lys Thr Leu Ser Asp Val Glu Asp Gln Lys Glu Leu
                165                 170                 175     
Ala Ser Pro Val Ser Pro Glu Leu Arg Gln Lys Glu Val Gln Met Asn
            180                 185                 190         
Phe Leu Asn Gln Leu Thr Ser Val Phe Asn Pro Arg Thr Val Ala Ser
        195                 200                 205             
Gln Pro Ile Ser Thr Gln Thr Leu Val Glu Gly Glu Asn Asp Glu Gln
    210                 215                 220                 
Ser Ser Thr Asp Gln Ala Ser Ala Ile Lys Thr Lys Asn Val Phe Ile
225                 230                 235                 240 
Ala Gln Asn Val Ala Ser Leu Gln Glu Leu Gly Gly Ser Glu Lys Leu
                245                 250                 255     
Leu Arg Val Cys Leu Asn Leu Pro Tyr Phe Leu Arg Tyr Ile Asn Arg
            260                 265                 270         
Phe Gln Asp Ala Val Leu Ala Asn Ser Phe Phe Ile Met Pro Ala Thr
        275                 280                 285             
Val Ala Asp Ala Thr Ala Val Arg Asn Gly Phe His Ser Leu Val Ile
    290                 295                 300                 
Asp Val Thr Met Ala Leu Asp Thr Leu Ser Leu Pro Val Leu Glu Pro
305                 310                 315                 320 
Leu Asn Pro Ser Arg Leu Gln Asp Val Thr Val Leu Ser Leu Ser Cys
                325                 330                 335     
Leu Tyr Ala Gly Val Ser Val Ala Thr Cys Met Ala Ile Leu His Val
            340                 345                 350         
Gly Ser Ala Gln Gln Val Arg Thr Gly Ser Thr Ser Ser Lys Glu Asp
        355                 360                 365             
Asp Tyr Glu Ser Asp Ala Ala Thr Ile Val Gln Lys Cys Leu Glu Ile
    370                 375                 380                 
Tyr Asp Met Ile Gly Gln Ala Ile Ser Ser Ser Arg Arg Ala Gly Gly
385                 390                 395                 400 
Glu His Tyr Gln Asn Phe Gln Leu Leu Gly Ala Trp Cys Leu Leu Asn
                405                 410                 415     
Ser Leu Phe Leu Ile Leu Asn Leu Ser Pro Thr Ala Leu Ala Asp Lys
            420                 425                 430         
Gly Lys Glu Lys Asp Pro Leu Ala Ala Leu Arg Val Arg Asp Ile Leu
        435                 440                 445             
Ser Arg Thr Lys Glu Gly Val Gly Ser Pro Lys Leu Gly Pro Gly Lys
    450                 455                 460                 
Gly His Gln Gly Phe Gly Val Leu Ser Val Ile Leu Ala Asn His Ala
465                 470                 475                 480 
Ile Lys Leu Leu Thr Ser Leu Phe Gln Asp Leu Gln Val Glu Ala Leu
                485                 490                 495     
His Lys Gly Trp Glu Thr Asp Gly Pro Pro Ala Ala Leu Ser Ile Met
            500                 505                 510         
Ala Gln Ser Thr Ser Ile Gln Arg Ile Gln Arg Leu Ile Asp Ser Val
        515                 520                 525             
Pro Leu Met Asn Leu Leu Leu Thr Leu Leu Ser Thr Ser Tyr Arg Lys
    530                 535                 540                 
Ala Cys Val Leu Gln Arg Gln Arg Lys Gly Ser Met Ser Ser Asp Ala
545                 550                 555                 560 
Ser Ala Ser Thr Asp Ser Asn Thr Tyr Tyr Glu Asp Asp Phe Ser Ser
                565                 570                 575     
Thr Glu Glu Asp Ser Ser Gln Asp Asp Asp Ser Glu Pro Ile Leu Gly
            580                 585                 590         
Gln Trp Phe Glu Glu Thr Ile Ser Pro Ser Lys Glu Lys Ala Ala Pro
        595                 600                 605             
Pro Pro Pro Pro Pro Pro Pro Pro Leu Glu Ser Ser Pro Arg Val Lys
    610                 615                 620                 
Ser Pro Ser Lys Gln Ala Pro Gly Glu Lys Gly Asn Ile Leu Ala Ser
625                 630                 635                 640 
Arg Lys Asp Pro Glu Leu Phe Leu Gly Leu Ala Ser Asn Ile Leu Asn
                645                 650                 655     
Phe Ile Thr Ser Ser Met Leu Asn Ser Arg Asn Asn Phe Ile Arg Asn
            660                 665                 670         
Tyr Leu Ser Val Ser Leu Ser Glu His His Met Ala Thr Leu Ala Ser
        675                 680                 685             
Ile Ile Lys Glu Val Asp Lys Asp Gly Leu Lys Gly Ser Ser Asp Glu
    690                 695                 700                 
Glu Phe Ala Ala Ala Leu Tyr His Phe Asn His Ser Leu Val Thr Ser
705                 710                 715                 720 
Asp Leu Gln Ser Pro Asn Leu Gln Asn Thr Leu Leu Gln Gln Leu Gly
                725                 730                 735     
Val Ala Pro Phe Ser Glu Gly Pro Trp Pro Leu Tyr Ile His Pro Gln
            740                 745                 750         
Ser Leu Ser Val Leu Ser Arg Leu Leu Leu Ile Trp Gln His Lys Ala
        755                 760                 765             
Ser Ala Gln Gly Asp Pro Asp Val Pro Glu Cys Leu Lys Val Trp Asp
    770                 775                 780                 
Arg Phe Leu Ser Thr Met Lys Gln Asn Ala Leu Gln Gly Val Val Pro
785                 790                 795                 800 
Ser Glu Thr Glu Asp Leu Asn Val Glu His Leu Gln Met Leu Leu Leu
                805                 810                 815     
Ile Phe His Asn Phe Thr Glu Thr Gly Arg Arg Ala Ile Leu Ser Leu
            820                 825                 830         
Phe Val Gln Ile Ile Gln Glu Leu Ser Val Asn Met Asp Ala Gln Met
        835                 840                 845             
Arg Phe Val Pro Leu Ile Leu Ala Arg Leu Leu Leu Ile Phe Asp Tyr
    850                 855                 860                 
Leu Leu His Gln Tyr Ser Lys Ala Pro Val Tyr Leu Phe Glu Gln Val
865                 870                 875                 880 
Gln His Asn Leu Leu Ser Pro Pro Phe Gly Trp Ala Ser Gly Ser Gln
                885                 890                 895     
Asp Ser Asn Ser Arg Arg Ala Thr Thr Pro Leu Tyr His Gly Phe Lys
            900                 905                 910         
Glu Val Glu Glu Asn Trp Ser Lys His Phe Ser Ser Asp Ala Val Pro
        915                 920                 925             
His Pro Arg Phe Tyr Cys Val Leu Ser Pro Glu Ala Ser Glu Asp Asp
    930                 935                 940                 
Leu Asn Arg Leu Asp Ser Val Ala Cys Asp Val Leu Phe Ser Lys Leu
945                 950                 955                 960 
Val Lys Tyr Asp Glu Leu Tyr Ala Ala Leu Thr Ala Leu Leu Ala Ala
                965                 970                 975     
Gly Ser Gln Leu Asp Thr Val Arg Arg Lys Glu Asn Lys Asn Val Thr
            980                 985                 990         
Ala Leu Glu Ala Cys Ala Leu Gln Tyr Tyr Phe Leu Ile Leu Trp Arg
        995                 1000                1005            
Ile Leu Gly Ile Leu Pro Pro Ser Lys Thr Tyr Ile Asn Gln Leu Ser
    1010                1015                1020                
Met Asn Ser Pro Glu Met Ser Glu Cys Asp Ile Leu His Thr Leu Arg
1025                1030                1035                1040
Trp Ser Ser Arg Leu Arg Ile Ser Ser Tyr Val Asn Trp Ile Lys Asp
                1045                1050                1055    
His Leu Ile Lys Gln Gly Met Lys Ala Glu His Ala Ser Ser Leu Leu
            1060                1065                1070        
Glu Leu Ala Ser Thr Thr Lys Cys Ser Ser Val Lys Tyr Asp Val Glu
        1075                1080                1085            
Ile Val Glu Glu Tyr Phe Ala Arg Gln Ile Ser Ser Phe Cys Ser Ile
    1090                1095                1100                
Asp Cys Thr Thr Ile Leu Gln Leu His Glu Ile Pro Ser Leu Gln Ser
1105                1110                1115                1120
Ile Tyr Thr Leu Asp Ala Ala Ile Ser Lys Val Gln Val Ser Leu Asp
                1125                1130                1135    
Glu His Phe Ser Lys Met Ala Ala Glu Thr Asp Pro His Lys Ser Ser
            1140                1145                1150        
Glu Ile Thr Lys Asn Leu Leu Pro Ala Thr Leu Gln Leu Ile Asp Thr
        1155                1160                1165            
Tyr Ala Ser Phe Thr Arg Ala Tyr Leu Leu Gln Asn Phe Asn Glu Glu
    1170                1175                1180                
Gly Thr Thr Glu Lys Pro Ser Lys Glu Lys Leu Gln Gly Phe Ala Ala
1185                1190                1195                1200
Val Leu Ala Ile Gly Ser Ser Arg Cys Lys Ala Asn Thr Leu Gly Pro
                1205                1210                1215    
Thr Leu Val Gln Asn Leu Pro Ser Ser Val Gln Thr Val Cys Glu Ser
            1220                1225                1230        
Trp Asn Asn Ile Asn Thr Asn Glu Phe Pro Asn Ile Gly Ser Trp Arg
        1235                1240                1245            
Asn Ala Phe Ala Asn Asp Thr Ile Pro Ser Glu Ser Tyr Ile Ser Ala
    1250                1255                1260                
Val Gln Ala Ala His Leu Gly Thr Leu Cys Ser Gln Ser Leu Pro Leu
1265                1270                1275                1280
Ala Ala Ser Leu Lys His Thr Leu Leu Ser Leu Val Arg Leu Thr Gly
                1285                1290                1295    
Asp Leu Ile Val Trp Ser Asp Glu Met Asn Pro Pro Gln Val Ile Arg
            1300                1305                1310        
Thr Leu Leu Pro Leu Leu Leu Glu Ser Ser Thr Glu Ser Val Ala Glu
        1315                1320                1325            
Ile Ser Ser Asn Ser Leu Glu Arg Ile Leu Gly Pro Ala Glu Ser Asp
    1330                1335                1340                
Glu Phe Leu Ala Arg Val Tyr Glu Lys Leu Ile Thr Gly Cys Tyr Asn
1345                1350                1355                1360
Ile Leu Ala Asn His Ala Asp Pro Asn Ser Gly Leu Asp Glu Ser Ile
                1365                1370                1375    
Leu Glu Glu Cys Leu Gln Tyr Leu Glu Lys Gln Leu Glu Ser Ser Gln
            1380                1385                1390        
Ala Arg Lys Ala Met Glu Glu Phe Phe Ser Asp Ser Gly Glu Leu Val
        1395                1400                1405            
Gln Ile Met Met Ala Thr Ala Asn Glu Asn Leu Ser Ala Lys Phe Cys
    1410                1415                1420                
Asn Arg Val Leu Lys Phe Phe Thr Lys Leu Phe Gln Leu Thr Glu Lys
1425                1430                1435                1440
Ser Pro Asn Pro Ser Leu Leu His Leu Cys Gly Ser Leu Ala Gln Leu
                1445                1450                1455    
Ala Cys Val Glu Pro Val Arg Leu Gln Ala Trp Leu Thr Arg Met Thr
            1460                1465                1470        
Thr Ser Pro Pro Lys Asp Ser Asp Gln Leu Asp Val Ile Gln Glu Asn
        1475                1480                1485            
Arg Gln Leu Leu Gln Leu Leu Thr Thr Tyr Ile Val Arg Glu Asn Ser
    1490                1495                1500                
Gln Val Gly Glu Gly Val Cys Ala Val Leu Leu Gly Thr Leu Thr Pro
1505                1510                1515                1520
Met Ala Thr Glu Met Leu Ala Asn Gly Asp Gly Thr Gly Phe Pro Glu
                1525                1530                1535    
Leu Met Val Val Met Ala Thr Leu Ala Ser Ala Gly Gln Gly Ala Gly
            1540                1545                1550        
His Leu Gln Leu His Asn Ala Ala Val Asp Trp Leu Ser Arg Cys Lys
        1555                1560                1565            
Lys Tyr Leu Ser Gln Lys Asn Val Val Glu Lys Leu Asn Ala Asn Val
    1570                1575                1580                
Met His Gly Lys His Val Met Ile Leu Glu Cys Thr Cys His Ile Met
1585                1590                1595                1600
Ser Tyr Leu Ala Asp Val Thr Asn Ala Leu Ser Gln Ser Asn Gly Gln
                1605                1610                1615    
Gly Pro Ser His Leu Ser Val Asp Gly Glu Glu Arg Ala Ile Glu Val
            1620                1625                1630        
Asp Ser Asp Trp Val Glu Glu Leu Ala Val Glu Glu Glu Asp Ser Gln
        1635                1640                1645            
Ala Glu Asp Ser Asp Glu Asp Ser Leu Cys Asn Lys Leu Cys Thr Phe
    1650                1655                1660                
Thr Ile Thr Gln Lys Glu Phe Met Asn Gln His Trp Tyr His Cys His
1665                1670                1675                1680
Thr Cys Lys Met Val Asp Gly Val Gly Val Cys Thr Val Cys Ala Lys
                1685                1690                1695    
Val Cys His Lys Asp His Glu Ile Ser Tyr Ala Lys Tyr Gly Ser Phe
            1700                1705                1710        
Phe Cys Asp Cys Gly Ala Lys Glu Asp Gly Ser Cys Leu Ala Leu Val
        1715                1720                1725            
Lys Arg Thr Pro Ser Ser Gly Met Ser Ser Thr Met Lys Glu Ser Ala
    1730                1735                1740                
Phe Gln Ser Glu Pro Arg Ile Ser Glu Ser Leu Val Arg His Ala Ser
1745                1750                1755                1760
Thr Ser Ser Pro Ala Asp Lys Ala Lys Val Thr Ile Ser Asp Gly Lys
                1765                1770                1775    
Val Ala Asp Glu Glu Lys Pro Lys Lys Ser Ser Leu Cys Arg Thr Val
            1780                1785                1790        
Glu Gly Cys Arg Glu Glu Leu Gln Asn Gln Ala Asn Phe Ser Phe Ala
        1795                1800                1805            
Pro Leu Val Leu Asp Met Leu Asn Phe Leu Met Asp Ala Ile Gln Thr
    1810                1815                1820                
Asn Phe Gln Gln Ala Ser Ala Val Gly Ser Ser Ser Arg Ala Gln Gln
1825                1830                1835                1840
Ala Leu Ser Glu Leu His Thr Val Glu Lys Ala Val Glu Met Thr Asp
                1845                1850                1855    
Gln Leu Met Val Pro Thr Leu Gly Ser Gln Glu Gly Ala Phe Glu Asn
            1860                1865                1870        
Val Arg Met Asn Tyr Ser Gly Asp Gln Gly Gln Thr Ile Arg Gln Leu
        1875                1880                1885            
Ile Ser Ala His Val Leu Arg Arg Val Ala Met Cys Val Leu Ser Ser
    1890                1895                1900                
Pro His Gly Arg Arg Gln His Leu Ala Val Ser His Glu Lys Gly Lys
1905                1910                1915                1920
Ile Thr Val Leu Gln Leu Ser Ala Leu Leu Lys Gln Ala Asp Ser Ser
                1925                1930                1935    
Lys Arg Lys Leu Thr Leu Thr Arg Leu Ala Ser Ala Pro Val Pro Phe
            1940                1945                1950        
Thr Val Leu Ser Leu Thr Gly Asn Pro Cys Lys Glu Asp Tyr Leu Ala
        1955                1960                1965            
Val Cys Gly Leu Lys Asp Cys His Val Leu Thr Phe Ser Ser Ser Gly
    1970                1975                1980                
Ser Val Ser Asp His Leu Val Leu His Pro Gln Leu Ala Thr Gly Asn
1985                1990                1995                2000
Phe Ile Ile Lys Ala Val Trp Leu Pro Gly Ser Gln Thr Glu Leu Ala
                2005                2010                2015    
Ile Val Thr Ala Asp Phe Val Lys Ile Tyr Asp Leu Cys Val Asp Ala
            2020                2025                2030        
Leu Ser Pro Thr Phe Tyr Phe Leu Leu Pro Ser Ser Lys Ile Arg Asp
        2035                2040                2045            
Val Thr Phe Leu Phe Asn Glu Glu Gly Lys Asn Ile Ile Val Ile Met
    2050                2055                2060                
Ser Ser Ala Gly Tyr Ile Tyr Thr Gln Leu Met Glu Glu Ala Ser Ser
2065                2070                2075                2080
Ala Gln Gln Gly Pro Phe Tyr Val Thr Asn Val Leu Glu Ile Asn His
                2085                2090                2095    
Glu Asp Leu Lys Asp Ser Asn Ser Gln Val Ala Gly Gly Gly Val Ser
            2100                2105                2110        
Val Tyr Tyr Ser His Val Leu Gln Met Leu Phe Phe Ser Tyr Cys Gln
        2115                2120                2125            
Gly Lys Ser Phe Ala Ala Thr Ile Ser Arg Thr Thr Leu Glu Val Leu
    2130                2135                2140                
Gln Leu Phe Pro Ile Asn Ile Lys Ser Ser Asn Gly Gly Ser Lys Thr
2145                2150                2155                2160
Ser Pro Ala Leu Cys Gln Trp Ser Glu Val Met Asn His Pro Gly Leu
                2165                2170                2175    
Val Cys Cys Val Gln Gln Thr Thr Gly Val Pro Leu Val Val Met Val
            2180                2185                2190        
Lys Pro Asp Thr Phe Leu Ile Gln Glu Ile Lys Thr Leu Pro Ala Lys
        2195                2200                2205            
Ala Lys Ile Gln Asp Met Val Ala Ile Arg His Thr Ala Cys Asn Glu
    2210                2215                2220                
Gln Gln Arg Thr Thr Met Ile Leu Leu Cys Glu Asp Gly Ser Leu Arg
2225                2230                2235                2240
Ile Tyr Met Ala Asn Val Glu Asn Thr Ser Tyr Trp Leu Gln Pro Ser
                2245                2250                2255    
Leu Gln Pro Ser Ser Val Ile Ser Ile Met Lys Pro Val Arg Lys Arg
            2260                2265                2270        
Lys Thr Ala Thr Ile Thr Thr Arg Thr Ser Ser Gln Val Thr Phe Pro
        2275                2280                2285            
Ile Asp Phe Phe Glu His Asn Gln Gln Leu Thr Asp Val Glu Phe Gly
    2290                2295                2300                
Gly Asn Asp Leu Leu Gln Val Tyr Asn Ala Gln Gln Ile Lys His Arg
2305                2310                2315                2320
Leu Asn Ser Thr Gly Met Tyr Val Ala Asn Thr Lys Pro Gly Gly Phe
                2325                2330                2335    
Thr Ile Glu Ile Ser Asn Asn Asn Ser Thr Met Val Met Thr Gly Met
            2340                2345                2350        
Arg Ile Gln Ile Gly Thr Gln Ala Ile Glu Arg Ala Pro Ser Tyr Ile
        2355                2360                2365            
Glu Ile Phe Gly Arg Thr Met Gln Leu Asn Leu Ser Arg Ser Arg Trp
    2370                2375                2380                
Phe Asp Phe Pro Phe Thr Arg Glu Glu Ala Leu Gln Ala Asp Lys Lys
2385                2390                2395                2400
Leu Asn Leu Phe Ile Gly Ala Ser Val Asp Pro Ala Gly Val Thr Met
                2405                2410                2415    
Ile Asp Ala Val Lys Ile Tyr Gly Lys Thr Lys Glu Gln Phe Gly Trp
            2420                2425                2430        
Pro Asp Glu Pro Pro Glu Glu Phe Pro Ser Ala Ser Val Ser Asn Ile
        2435                2440                2445            
Cys Pro Ser Asn Leu Asn Gln Ser Asn Gly Thr Gly Asp Ser Asp Ser
    2450                2455                2460                
Ala Ala Pro Thr Thr Thr Ser Gly Thr Val Leu Glu Arg Leu Val Val
2465                2470                2475                2480
Ser Ser Leu Glu Ala Leu Glu Ser Cys Phe Ala Val Gly Pro Ile Ile
                2485                2490                2495    
Glu Lys Ala Arg Arg Asn Lys Asn Ala Ala Gln Glu Leu Ala Thr Leu
            2500                2505                2510        
Leu Leu Ser Leu Pro Ala Pro Ala Ser Val Gln Gln Gln Ser Lys Ser
        2515                2520                2525            
Leu Leu Ala Ser Leu His Thr Ser Arg Ser Ala Tyr His Ser His Lys
    2530                2535                2540                
Asp Gln Ala Leu Leu Ser Lys Ala Val Gln Cys Leu Asn Thr Ser Ser
2545                2550                2555                2560
Lys Glu Gly Lys Asp Leu Asp Pro Glu Val Phe Gln Arg Leu Val Ile
                2565                2570                2575    
Thr Ala Arg Ser Ile Ala Ile Met Arg Pro Asn Asn Leu Val His Phe
            2580                2585                2590        
Thr Glu Ser Lys Leu Pro Gln Met Glu Thr Glu Gly Met Asp Glu Gly
        2595                2600                2605            
Lys Glu Pro Gln Lys Gln Leu Glu Gly Asp Cys Cys Ser Phe Ile Thr
    2610                2615                2620                
Gln Leu Val Asn His Phe Trp Lys Leu His Ala Ser Lys Pro Lys Asn
2625                2630                2635                2640
Ala Phe Leu Ala Pro Ala Cys Leu Pro Gly Leu Thr His Ile Glu Ala
                2645                2650                2655    
Thr Val Asn Ala Leu Val Asp Ile Ile His Gly Tyr Cys Thr Cys Glu
            2660                2665                2670        
Leu Asp Cys Ile Asn Thr Ala Ser Lys Ile Tyr Met Gln Met Leu Leu
        2675                2680                2685            
Cys Pro Asp Pro Ala Val Ser Phe Ser Cys Lys Gln Ala Leu Ile Arg
    2690                2695                2700                
Val Leu Arg Pro Arg Asn Lys Arg Arg His Val Thr Leu Pro Ser Ser
2705                2710                2715                2720
Pro Arg Ser Asn Thr Pro Met Gly Asp Lys Asp Asp Asp Asp Asp Asp
                2725                2730                2735    
Asp Ala Asp Glu Lys Met Gln Ser Ser Gly Ile Pro Asn Gly Gly His
            2740                2745                2750        
Ile Arg Gln Glu Ser Gln Glu Gln Ser Glu Val Asp His Gly Asp Phe
        2755                2760                2765            
Glu Met Val Ser Glu Ser Met Val Leu Glu Thr Ala Glu Asn Val Asn
    2770                2775                2780                
Asn Gly Asn Pro Ser Pro Leu Glu Ala Leu Leu Ala Gly Ala Glu Gly
2785                2790                2795                2800
Phe Pro Pro Met Leu Asp Ile Pro Pro Asp Ala Asp Asp Glu Thr Met
                2805                2810                2815    
Val Glu Leu Ala Ile Ala Leu Ser Leu Gln Gln Asp Gln Gln Gly Ser
            2820                2825                2830        
Ser Ser Ser Ala Leu Gly Leu Gln Ser Leu Gly Leu Ser Gly Gln Ala
        2835                2840                2845            
Pro Ser Ser Ser Ser Leu Asp Ala Gly Thr Leu Ser Asp Thr Thr Ala
    2850                2855                2860                
Ser Ala Pro Ala Ser Asp Asp Glu Gly Ser Thr Ala Ala Thr Asp Gly
2865                2870                2875                2880
Ser Thr Leu Arg Thr Ser Pro Ala Asp His Gly Gly Ser Val Gly Ser
                2885                2890                2895    
Glu Ser Gly Gly Ser Ala Val Asp Ser Val Ala Gly Glu His Ser Val
            2900                2905                2910        
Ser Gly Arg Ser Ser Ala Tyr Gly Asp Ala Thr Ala Glu Gly His Pro
        2915                2920                2925            
Ala Gly Pro Gly Ser Val Ser Ser Ser Thr Gly Ala Ile Ser Thr Thr
    2930                2935                2940                
Thr Gly His Gln Glu Gly Asp Gly Ser Glu Gly Glu Gly Glu Gly Glu
2945                2950                2955                2960
Thr Glu Gly Asp Val His Thr Ser Asn Arg Leu His Met Val Arg Leu
                2965                2970                2975    
Met Leu Leu Glu Arg Leu Leu Gln Thr Leu Pro Gln Leu Arg Asn Val
            2980                2985                2990        
Gly Gly Val Arg Ala Ile Pro Tyr Met Gln Val Ile Leu Met Leu Thr
        2995                3000                3005            
Thr Asp Leu Asp Gly Glu Asp Glu Lys Asp Lys Gly Ala Leu Asp Asn
    3010                3015                3020                
Leu Leu Ser Gln Leu Ile Ala Glu Leu Gly Met Asp Lys Lys Asp Val
3025                3030                3035                3040
Ser Lys Lys Asn Glu Arg Ser Ala Leu Asn Glu Val His Leu Val Val
                3045                3050                3055    
Met Arg Leu Leu Ser Val Phe Met Ser Arg Thr Lys Ser Gly Ser Lys
            3060                3065                3070        
Ser Ser Ile Cys Glu Ser Ser Ser Leu Ile Ser Ser Ala Thr Ala Ala
        3075                3080                3085            
Ala Leu Leu Ser Ser Gly Ala Val Asp Tyr Cys Leu His Val Leu Lys
    3090                3095                3100                
Ser Leu Leu Glu Tyr Trp Lys Ser Gln Gln Asn Asp Glu Glu Pro Val
3105                3110                3115                3120
Ala Thr Ser Gln Leu Leu Lys Pro His Thr Thr Ser Ser Pro Pro Asp
                3125                3130                3135    
Met Ser Pro Phe Phe Leu Arg Gln Tyr Val Lys Gly His Ala Ala Asp
            3140                3145                3150        
Val Phe Glu Ala Tyr Thr Gln Leu Leu Thr Glu Met Val Leu Arg Leu
        3155                3160                3165            
Pro Tyr Gln Ile Lys Lys Ile Thr Asp Thr Asn Ser Arg Ile Pro Pro
    3170                3175                3180                
Pro Val Phe Asp His Ser Trp Phe Tyr Phe Leu Ser Glu Tyr Leu Met
3185                3190                3195                3200
Ile Gln Gln Thr Pro Phe Val Arg Arg Gln Val Arg Lys Leu Leu Leu
                3205                3210                3215    
Phe Ile Cys Gly Ser Lys Glu Lys Tyr Arg Gln Leu Arg Asp Leu His
            3220                3225                3230        
Thr Leu Asp Ser His Val Arg Gly Ile Lys Lys Leu Leu Glu Glu Gln
        3235                3240                3245            
Gly Ile Phe Leu Arg Ala Ser Val Val Thr Ala Ser Ser Gly Ser Ala
    3250                3255                3260                
Leu Gln Tyr Asp Thr Leu Ile Ser Leu Met Glu His Leu Lys Ala Cys
3265                3270                3275                3280
Ala Glu Ile Ala Ala Gln Arg Thr Ile Asn Trp Gln Lys Phe Cys Ile
                3285                3290                3295    
Lys Asp Asp Ser Val Leu Tyr Phe Leu Leu Gln Val Ser Phe Leu Val
            3300                3305                3310        
Asp Glu Gly Val Ser Pro Val Leu Leu Gln Leu Leu Ser Cys Ala Leu
        3315                3320                3325            
Cys Gly Ser Lys Val Leu Ala Ala Leu Ala Ala Ser Ser Gly Ser Ser
    3330                3335                3340                
Ser Ala Ser Ser Ser Ser Ala Pro Val Ala Ala Ser Ser Gly Gln Ala
3345                3350                3355                3360
Thr Thr Gln Ser Lys Ser Ser Thr Lys Lys Ser Lys Lys Glu Glu Lys
                3365                3370                3375    
Glu Lys Glu Lys Asp Gly Glu Thr Ser Gly Ser Gln Glu Asp Gln Leu
            3380                3385                3390        
Cys Thr Ala Leu Val Asn Gln Leu Asn Lys Phe Ala Asp Lys Glu Thr
        3395                3400                3405            
Leu Ile Gln Phe Leu Arg Cys Phe Leu Leu Glu Ser Asn Ser Ser Ser
    3410                3415                3420                
Val Arg Trp Gln Ala His Cys Leu Thr Leu His Ile Tyr Arg Asn Ser
3425                3430                3435                3440
Ser Lys Ser Gln Gln Glu Leu Leu Leu Asp Leu Met Trp Ser Ile Trp
                3445                3450                3455    
Pro Glu Leu Pro Ala Tyr Gly Arg Lys Ala Ala Gln Phe Val Asp Leu
            3460                3465                3470        
Leu Gly Tyr Phe Ser Leu Lys Thr Pro Gln Thr Glu Lys Lys Leu Lys
        3475                3480                3485            
Glu Tyr Ser Gln Lys Ala Val Glu Ile Leu Arg Thr Gln Asn His Ile
    3490                3495                3500                
Leu Thr Asn His Pro Asn Ser Asn Ile Tyr Asn Thr Leu Ser Gly Leu
3505                3510                3515                3520
Val Glu Phe Asp Gly Tyr Tyr Leu Glu Ser Asp Pro Cys Leu Val Cys
                3525                3530                3535    
Asn Asn Pro Glu Val Pro Phe Cys Tyr Ile Lys Leu Ser Ser Ile Lys
            3540                3545                3550        
Val Asp Thr Arg Tyr Thr Thr Thr Gln Gln Val Val Lys Leu Ile Gly
        3555                3560                3565            
Ser His Thr Ile Ser Lys Val Thr Val Lys Ile Gly Asp Leu Lys Arg
    3570                3575                3580                
Thr Lys Met Val Arg Thr Ile Asn Leu Tyr Tyr Asn Asn Arg Thr Val
3585                3590                3595                3600
Gln Ala Ile Val Glu Leu Lys Asn Lys Pro Ala Arg Trp His Lys Ala
                3605                3610                3615    
Lys Lys Val Gln Leu Thr Pro Gly Gln Thr Glu Val Lys Ile Asp Leu
            3620                3625                3630        
Pro Leu Pro Ile Val Ala Ser Asn Leu Met Ile Glu Phe Ala Asp Phe
        3635                3640                3645            
Tyr Glu Asn Tyr Gln Ala Ser Thr Glu Thr Leu Gln Cys Pro Arg Cys
    3650                3655                3660                
Ser Ala Ser Val Pro Ala Asn Pro Gly Val Cys Gly Asn Cys Gly Glu
3665                3670                3675                3680
Asn Val Tyr Gln Cys His Lys Cys Arg Ser Ile Asn Tyr Asp Glu Lys
                3685                3690                3695    
Asp Pro Phe Leu Cys Asn Ala Cys Gly Phe Cys Lys Tyr Ala Arg Phe
            3700                3705                3710        
Asp Phe Met Leu Tyr Ala Lys Pro Cys Cys Ala Val Asp Pro Ile Glu
        3715                3720                3725            
Asn Glu Glu Asp Arg Lys Lys Ala Val Ser Asn Ile Asn Thr Leu Leu
    3730                3735                3740                
Asp Lys Ala Asp Arg Val Tyr His Gln Leu Met Gly His Arg Pro Gln
3745                3750                3755                3760
Leu Glu Asn Leu Leu Cys Lys Val Asn Glu Ala Ala Pro Glu Lys Pro
                3765                3770                3775    
Gln Asp Asp Ser Gly Thr Ala Gly Gly Ile Ser Ser Thr Ser Ala Ser
            3780                3785                3790        
Val Asn Arg Tyr Ile Leu Gln Leu Ala Gln Glu Tyr Cys Gly Asp Cys
        3795                3800                3805            
Lys Asn Ser Phe Asp Glu Leu Ser Lys Ile Ile Gln Lys Val Phe Ala
    3810                3815                3820                
Ser Arg Lys Glu Leu Leu Glu Tyr Asp Leu Gln Gln Arg Glu Ala Ala
3825                3830                3835                3840
Thr Lys Ser Ser Arg Thr Ser Val Gln Pro Thr Phe Thr Ala Ser Gln
                3845                3850                3855    
Tyr Arg Ala Leu Ser Val Leu Gly Cys Gly His Thr Ser Ser Thr Lys
            3860                3865                3870        
Cys Tyr Gly Cys Ala Ser Ala Val Thr Glu His Cys Ile Thr Leu Leu
        3875                3880                3885            
Arg Ala Leu Ala Thr Asn Pro Ala Leu Arg His Ile Leu Val Ser Gln
    3890                3895                3900                
Gly Leu Ile Arg Glu Leu Phe Asp Tyr Asn Leu Arg Arg Gly Ala Ala
3905                3910                3915                3920
Ala Met Arg Glu Glu Val Arg Gln Leu Met Cys Leu Leu Thr Arg Asp
                3925                3930                3935    
Asn Pro Glu Ala Thr Gln Gln Met Asn Asp Leu Ile Ile Gly Lys Val
            3940                3945                3950        
Ser Thr Ala Leu Lys Gly His Trp Ala Asn Pro Asp Leu Ala Ser Ser
        3955                3960                3965            
Leu Gln Tyr Glu Met Leu Leu Leu Thr Asp Ser Ile Ser Lys Glu Asp
    3970                3975                3980                
Ser Cys Trp Glu Leu Arg Leu Arg Cys Ala Leu Ser Leu Phe Leu Met
3985                3990                3995                4000
Ala Val Asn Ile Lys Thr Pro Val Val Val Glu Asn Ile Thr Leu Met
                4005                4010                4015    
Cys Leu Arg Ile Leu Gln Lys Leu Ile Lys Pro Pro Ala Pro Thr Ser
            4020                4025                4030        
Lys Lys Asn Lys Asp Val Pro Val Glu Ala Leu Thr Thr Val Lys Pro
        4035                4040                4045            
Tyr Cys Asn Glu Ile His Ala Gln Ala Gln Leu Trp Leu Lys Arg Asp
    4050                4055                4060                
Pro Lys Ala Ser Tyr Asp Ala Trp Lys Lys Cys Leu Pro Ile Arg Gly
4065                4070                4075                4080
Ile Asp Gly Asn Gly Lys Ala Pro Ser Lys Ser Glu Leu Arg His Leu
                4085                4090                4095    
Tyr Leu Thr Glu Lys Tyr Val Trp Arg Trp Lys Gln Phe Leu Ser Arg
            4100                4105                4110        
Arg Gly Lys Arg Thr Ser Pro Leu Asp Leu Lys Leu Gly His Asn Asn
        4115                4120                4125            
Trp Leu Arg Gln Val Leu Phe Thr Pro Ala Thr Gln Ala Ala Arg Gln
    4130                4135                4140                
Ala Ala Cys Thr Ile Val Glu Ala Leu Ala Thr Ile Pro Ser Arg Lys
4145                4150                4155                4160
Gln Gln Val Leu Asp Leu Leu Thr Ser Tyr Leu Asp Glu Leu Ser Ile
                4165                4170                4175    
Ala Gly Glu Cys Ala Ala Glu Tyr Leu Ala Leu Tyr Gln Lys Leu Ile
            4180                4185                4190        
Thr Ser Ala His Trp Lys Val Tyr Leu Ala Ala Arg Gly Val Leu Pro
        4195                4200                4205            
Tyr Val Gly Asn Leu Ile Thr Lys Glu Ile Ala Arg Leu Leu Ala Leu
    4210                4215                4220                
Glu Glu Ala Thr Leu Ser Thr Asp Leu Gln Gln Gly Tyr Ala Leu Lys
4225                4230                4235                4240
Ser Leu Thr Gly Leu Leu Ser Ser Phe Val Glu Val Glu Ser Ile Lys
                4245                4250                4255    
Arg His Phe Lys Ser Arg Leu Val Gly Thr Val Leu Asn Gly Tyr Leu
            4260                4265                4270        
Cys Leu Arg Lys Leu Val Val Gln Arg Thr Lys Leu Ile Asp Glu Thr
        4275                4280                4285            
Gln Asp Met Leu Leu Glu Met Leu Glu Asp Met Thr Thr Gly Thr Glu
    4290                4295                4300                
Ser Glu Thr Lys Ala Phe Met Ala Val Cys Ile Glu Thr Ala Lys Arg
4305                4310                4315                4320
Tyr Asn Leu Asp Asp Tyr Arg Thr Pro Val Phe Ile Phe Glu Arg Leu
                4325                4330                4335    
Cys Ser Ile Ile Tyr Pro Glu Glu Asn Glu Val Thr Glu Phe Phe Val
            4340                4345                4350        
Thr Leu Glu Lys Asp Pro Gln Gln Glu Asp Phe Leu Gln Gly Arg Met
        4355                4360                4365            
Pro Gly Asn Pro Tyr Ser Ser Asn Glu Pro Gly Ile Gly Pro Leu Met
    4370                4375                4380                
Arg Asp Ile Lys Asn Lys Ile Cys Gln Asp Cys Asp Leu Val Ala Leu
4385                4390                4395                4400
Leu Glu Asp Asp Ser Gly Met Glu Leu Leu Val Asn Asn Lys Ile Ile
                4405                4410                4415    
Ser Leu Asp Leu Pro Val Ala Glu Val Tyr Lys Lys Val Trp Cys Thr
            4420                4425                4430        
Thr Asn Glu Gly Glu Pro Met Arg Ile Val Tyr Arg Met Arg Gly Leu
        4435                4440                4445            
Leu Gly Asp Ala Thr Glu Glu Phe Ile Glu Ser Leu Asp Ser Thr Thr
    4450                4455                4460                
Asp Glu Glu Glu Asp Glu Glu Glu Val Tyr Lys Met Ala Gly Val Met
4465                4470                4475                4480
Ala Gln Cys Gly Gly Leu Glu Cys Met Leu Asn Arg Leu Ala Gly Ile
                4485                4490                4495    
Arg Asp Phe Lys Gln Gly Arg His Leu Leu Thr Val Leu Leu Lys Leu
            4500                4505                4510        
Phe Ser Tyr Cys Val Lys Val Lys Val Asn Arg Gln Gln Leu Val Lys
        4515                4520                4525            
Leu Glu Met Asn Thr Leu Asn Val Met Leu Gly Thr Leu Asn Leu Ala
    4530                4535                4540                
Leu Val Ala Glu Gln Glu Ser Lys Asp Ser Gly Gly Ala Ala Val Ala
4545                4550                4555                4560
Glu Gln Val Leu Ser Ile Met Glu Ile Ile Leu Asp Glu Ser Asn Ala
                4565                4570                4575    
Glu Pro Leu Ser Glu Asp Lys Gly Asn Leu Leu Leu Thr Gly Asp Lys
            4580                4585                4590        
Asp Gln Leu Val Met Leu Leu Asp Gln Ile Asn Ser Thr Phe Val Arg
        4595                4600                4605            
Ser Asn Pro Ser Val Leu Gln Gly Leu Leu Arg Ile Ile Pro Tyr Leu
    4610                4615                4620                
Ser Phe Gly Glu Val Glu Lys Met Gln Ile Leu Val Glu Arg Phe Lys
4625                4630                4635                4640
Pro Tyr Cys Asn Phe Asp Lys Tyr Asp Glu Asp His Ser Gly Asp Asp
                4645                4650                4655    
Lys Val Phe Leu Asp Cys Phe Cys Lys Ile Ala Ala Gly Ile Lys Asn
            4660                4665                4670        
Asn Ser Asn Gly His Gln Leu Lys Asp Leu Ile Leu Gln Lys Gly Ile
        4675                4680                4685            
Thr Gln Asn Ala Leu Asp Tyr Met Lys Lys His Ile Pro Ser Ala Lys
    4690                4695                4700                
Asn Leu Asp Ala Asp Ile Trp Lys Lys Phe Leu Ser Arg Pro Ala Leu
4705                4710                4715                4720
Pro Phe Ile Leu Arg Leu Leu Arg Gly Leu Ala Ile Gln His Pro Gly
                4725                4730                4735    
Thr Gln Val Leu Ile Gly Thr Asp Ser Ile Pro Asn Leu His Lys Leu
            4740                4745                4750        
Glu Gln Val Ser Ser Asp Glu Gly Ile Gly Thr Leu Ala Glu Asn Leu
        4755                4760                4765            
Leu Glu Ala Leu Arg Glu His Pro Asp Val Asn Lys Lys Ile Asp Ala
    4770                4775                4780                
Ala Arg Arg Glu Thr Arg Ala Glu Lys Lys Arg Met Ala Met Ala Met
4785                4790                4795                4800
Arg Gln Lys Ala Leu Gly Thr Leu Gly Met Thr Thr Asn Glu Lys Gly
                4805                4810                4815    
Gln Val Val Thr Lys Thr Ala Leu Leu Lys Gln Met Glu Glu Leu Ile
            4820                4825                4830        
Glu Glu Pro Gly Leu Thr Cys Cys Ile Cys Arg Glu Gly Tyr Lys Phe
        4835                4840                4845            
Gln Pro Thr Lys Val Leu Gly Ile Tyr Thr Phe Thr Lys Arg Val Ala
    4850                4855                4860                
Leu Glu Glu Met Glu Asn Lys Pro Arg Lys Gln Gln Gly Tyr Ser Thr
4865                4870                4875                4880
Val Ser His Phe Asn Ile Val His Tyr Asp Cys His Leu Ala Ala Val
                4885                4890                4895    
Arg Leu Ala Arg Gly Arg Glu Glu Trp Glu Ser Ala Ala Leu Gln Asn
            4900                4905                4910        
Ala Asn Thr Lys Cys Asn Gly Leu Leu Pro Val Trp Gly Pro His Val
        4915                4920                4925            
Pro Glu Ser Ala Phe Ala Thr Cys Leu Ala Arg His Asn Thr Tyr Leu
    4930                4935                4940                
Gln Glu Cys Thr Gly Gln Arg Glu Pro Thr Tyr Gln Leu Asn Ile His
4945                4950                4955                4960
Asp Ile Lys Leu Leu Phe Leu Arg Phe Ala Met Glu Gln Ser Phe Ser
                4965                4970                4975    
Ala Asp Thr Gly Gly Gly Gly Arg Glu Ser Asn Ile His Leu Ile Pro
            4980                4985                4990        
Tyr Ile Ile His Thr Val Leu Tyr Val Leu Asn Thr Thr Arg Ala Thr
        4995                5000                5005            
Ser Arg Glu Glu Lys Asn Leu Gln Gly Phe Leu Glu Gln Pro Lys Glu
    5010                5015                5020                
Lys Trp Val Glu Ser Ala Phe Glu Val Asp Gly Pro Tyr Tyr Phe Thr
5025                5030                5035                5040
Val Leu Ala Leu His Ile Leu Pro Pro Glu Gln Trp Arg Ala Thr Arg
                5045                5050                5055    
Val Glu Ile Leu Arg Arg Leu Leu Val Thr Ser Gln Ala Arg Ala Val
            5060                5065                5070        
Ala Pro Gly Gly Ala Thr Arg Leu Thr Asp Lys Ala Val Lys Asp Tyr
        5075                5080                5085            
Ser Ala Tyr Arg Ser Ser Leu Leu Phe Trp Ala Leu Val Asp Leu Ile
    5090                5095                5100                
Tyr Asn Met Phe Lys Lys Val Pro Thr Ser Asn Thr Glu Gly Gly Trp
5105                5110                5115                5120
Ser Cys Ser Leu Ala Glu Tyr Ile Arg His Asn Asp Met Pro Ile Tyr
                5125                5130                5135    
Glu Ala Ala Asp Lys Ala Leu Lys Thr Phe Gln Glu Glu Phe Met Pro
            5140                5145                5150        
Val Glu Thr Phe Ser Glu Phe Leu Asp Val Ala Gly Leu Leu Ser Glu
        5155                5160                5165            
Ile Thr Asp Pro Glu Ser Phe Leu Lys Asp Leu Leu Asn Ser Val Pro
    5170                5175                5180                


<210> 8471
<211> 1091
<212> PRT
<213> Homo sapiens

<400> 8471
Met Cys Arg Lys Lys Pro Asp Thr Met Ile Leu Thr Gln Ile Glu Ala
 1               5                  10                  15      
Lys Glu Ala Cys Asp Trp Leu Arg Ala Thr Gly Phe Pro Gln Tyr Ala
            20                  25                  30          
Gln Leu Tyr Glu Asp Phe Leu Phe Pro Ile Asp Ile Ser Leu Val Lys
        35                  40                  45              
Arg Glu His Asp Phe Leu Asp Arg Asp Ala Ile Glu Ala Leu Cys Arg
    50                  55                  60                  
Arg Leu Asn Thr Leu Asn Lys Cys Ala Val Met Lys Leu Glu Ile Ser
65                  70                  75                  80  
Pro His Arg Lys Arg Ser Asp Asp Ser Asp Glu Asp Glu Pro Cys Ala
                85                  90                  95      
Ile Ser Gly Lys Trp Thr Phe Gln Arg Asp Ser Lys Arg Trp Ser Arg
            100                 105                 110         
Leu Glu Glu Phe Asp Val Phe Ser Pro Lys Gln Asp Leu Val Pro Gly
        115                 120                 125             
Ser Pro Asp Asp Ser His Pro Lys Asp Gly Pro Ser Pro Gly Gly Thr
    130                 135                 140                 
Leu Met Asp Leu Ser Glu Arg Gln Glu Val Ser Ser Val Arg Ser Leu
145                 150                 155                 160 
Ser Ser Thr Gly Ser Leu Pro Ser His Ala Pro Pro Ser Glu Asp Ala
                165                 170                 175     
Ala Thr Pro Arg Thr Asn Ser Val Ile Ser Val Cys Ser Ser Ser Asn
            180                 185                 190         
Leu Ala Gly Asn Asp Asp Ser Phe Gly Ser Leu Pro Ser Pro Lys Glu
        195                 200                 205             
Leu Ser Ser Phe Ser Phe Ser Met Lys Gly His Glu Lys Thr Ala Lys
    210                 215                 220                 
Ser Lys Thr Arg Ser Leu Leu Lys Arg Met Glu Ser Leu Lys Leu Lys
225                 230                 235                 240 
Ser Ser His His Ser Lys His Lys Ala Pro Ser Lys Leu Gly Leu Ile
                245                 250                 255     
Ile Ser Gly Pro Ile Leu Gln Glu Gly Met Asp Glu Glu Lys Leu Lys
            260                 265                 270         
Gln Leu Asn Cys Val Glu Ile Ser Ala Leu Asn Gly Asn Arg Ile Asn
        275                 280                 285             
Val Pro Met Val Arg Lys Arg Ser Val Ser Asn Ser Thr Gln Thr Ser
    290                 295                 300                 
Ser Ser Ser Ser Gln Ser Glu Thr Ser Ser Ala Val Ser Thr Pro Ser
305                 310                 315                 320 
Pro Val Thr Arg Thr Arg Ser Leu Ser Ala Cys Asn Lys Arg Val Gly
                325                 330                 335     
Met Tyr Leu Glu Gly Phe Asp Pro Phe Asn Gln Ser Thr Phe Asn Asn
            340                 345                 350         
Val Met Glu Gln Asn Phe Lys Asn Arg Glu Ser Tyr Pro Glu Asp Thr
        355                 360                 365             
Val Phe Tyr Ile Pro Glu Asp His Lys Pro Gly Thr Phe Pro Lys Ala
    370                 375                 380                 
Leu Thr Asn Gly Ser Phe Ser Pro Ser Gly Asn Asn Gly Ser Val Asn
385                 390                 395                 400 
Trp Arg Thr Gly Ser Phe His Gly Pro Gly His Ile Ser Leu Arg Arg
                405                 410                 415     
Glu Asn Ser Ser Asp Ser Pro Lys Glu Leu Lys Arg Arg Asn Ser Ser
            420                 425                 430         
Ser Ser Met Ser Ser Arg Leu Ser Ile Tyr Asp Asn Val Pro Gly Ser
        435                 440                 445             
Ile Leu Tyr Ser Ser Ser Gly Asp Leu Ala Asp Leu Glu Asn Glu Asp
    450                 455                 460                 
Ile Phe Pro Glu Leu Asp Asp Ile Leu Tyr His Val Lys Gly Met Gln
465                 470                 475                 480 
Arg Ile Val Asn Gln Trp Ser Glu Lys Phe Ser Asp Glu Gly Asp Ser
                485                 490                 495     
Asp Ser Ala Leu Asp Ser Val Ser Pro Cys Pro Ser Ser Pro Lys Gln
            500                 505                 510         
Ile His Leu Asp Val Asp Asn Asp Arg Thr Thr Pro Ser Asp Leu Asp
        515                 520                 525             
Ser Thr Gly Asn Ser Leu Asn Glu Pro Glu Glu Pro Ser Glu Ile Pro
    530                 535                 540                 
Glu Arg Arg Asp Ser Gly Val Gly Ala Ser Leu Thr Arg Ser Asn Arg
545                 550                 555                 560 
His Arg Leu Arg Trp His Ser Phe Gln Ser Ser His Arg Pro Ser Leu
                565                 570                 575     
Asn Ser Val Ser Leu Gln Ile Asn Cys Gln Ser Val Ala Gln Met Asn
            580                 585                 590         
Leu Leu Gln Lys Tyr Ser Leu Leu Lys Leu Thr Ala Leu Leu Glu Lys
        595                 600                 605             
Tyr Thr Pro Ser Asn Lys His Gly Phe Ser Trp Ala Val Pro Lys Phe
    610                 615                 620                 
Met Lys Arg Ile Lys Val Pro Asp Tyr Lys Asp Arg Ser Val Phe Gly
625                 630                 635                 640 
Val Pro Leu Thr Val Asn Val Gln Arg Thr Gly Gln Pro Leu Pro Gln
                645                 650                 655     
Ser Ile Gln Gln Ala Met Arg Tyr Leu Arg Asn His Cys Leu Asp Gln
            660                 665                 670         
Val Gly Leu Phe Arg Lys Ser Gly Val Lys Ser Arg Ile Gln Ala Leu
        675                 680                 685             
Arg Gln Met Asn Glu Gly Ala Ile Asp Cys Val Asn Tyr Glu Gly Gln
    690                 695                 700                 
Ser Ala Tyr Asp Val Ala Asp Met Leu Lys Gln Tyr Phe Arg Asp Leu
705                 710                 715                 720 
Pro Glu Pro Leu Met Thr Asn Lys Leu Ser Glu Thr Phe Leu Gln Ile
                725                 730                 735     
Tyr Gln Tyr Val Pro Lys Asp Gln Arg Leu Gln Ala Ile Lys Ala Ala
            740                 745                 750         
Ile Met Leu Leu Pro Asp Glu Asn Arg Glu Val Leu Gln Thr Leu Leu
        755                 760                 765             
Tyr Phe Leu Ser Asp Val Thr Ala Ala Val Lys Glu Asn Gln Met Thr
    770                 775                 780                 
Pro Thr Asn Leu Ala Val Cys Leu Ala Pro Ser Leu Phe His Leu Asn
785                 790                 795                 800 
Thr Leu Lys Arg Glu Asn Ser Ser Pro Arg Val Met Gln Arg Lys Gln
                805                 810                 815     
Ser Leu Gly Lys Pro Asp Gln Lys Asp Leu Asn Glu Asn Leu Ala Ala
            820                 825                 830         
Thr Gln Gly Leu Ala His Met Ile Ala Glu Cys Lys Lys Leu Phe Gln
        835                 840                 845             
Val Pro Glu Glu Met Ser Arg Cys Arg Asn Ser Tyr Thr Glu Gln Glu
    850                 855                 860                 
Leu Lys Pro Leu Thr Leu Glu Ala Leu Gly His Leu Gly Asn Asp Asp
865                 870                 875                 880 
Ser Ala Asp Tyr Gln His Phe Leu Gln Asp Cys Val Asp Gly Leu Phe
                885                 890                 895     
Lys Glu Val Lys Glu Lys Phe Lys Gly Trp Val Ser Tyr Ser Thr Ser
            900                 905                 910         
Glu Gln Ala Glu Leu Ser Tyr Lys Lys Val Ser Glu Gly Pro Pro Leu
        915                 920                 925             
Arg Leu Trp Arg Ser Val Ile Glu Val Pro Ala Val Pro Glu Glu Ile
    930                 935                 940                 
Leu Lys Arg Leu Leu Lys Glu Gln His Leu Trp Asp Val Asp Leu Leu
945                 950                 955                 960 
Asp Ser Lys Val Ile Glu Ile Leu Asp Ser Gln Thr Glu Ile Tyr Gln
                965                 970                 975     
Tyr Val Gln Asn Ser Met Ala Pro His Pro Ala Arg Asp Tyr Val Val
            980                 985                 990         
Leu Arg Thr Trp Arg Thr Asn Leu Pro Lys Gly Ala Cys Ala Leu Leu
        995                 1000                1005            
Leu Thr Ser Val Asp His Asp Arg Ala Pro Val Val Gly Val Arg Val
    1010                1015                1020                
Asn Val Leu Leu Ser Arg Tyr Leu Ile Glu Pro Cys Gly Pro Gly Lys
1025                1030                1035                1040
Ser Lys Leu Thr Tyr Met Cys Arg Val Asp Leu Arg Gly His Met Pro
                1045                1050                1055    
Glu Trp Tyr Thr Lys Ser Phe Gly His Leu Cys Ala Ala Glu Val Val
            1060                1065                1070        
Lys Ile Arg Asp Ser Phe Ser Asn Gln Asn Thr Glu Thr Lys Asp Thr
        1075                1080                1085            
Lys Ser Arg
    1090    


<210> 8472
<211> 1528
<212> PRT
<213> Homo sapiens

<400> 8472
Met Ser Val Ala Ile Arg Lys Arg Ser Trp Glu Glu His Val Thr His
 1               5                  10                  15      
Trp Met Gly Gln Pro Phe Asn Ser Asp Asp Arg Asn Thr Ala Cys His
            20                  25                  30          
His Gly Leu Val Ala Asp Ser Leu Gln Ala Ser Met Glu Lys Asp Ala
        35                  40                  45              
Thr Leu Asn Val Asp Arg Lys Glu Lys Cys Val Ser Leu Pro Asp Cys
    50                  55                  60                  
Cys His Gly Ser Glu Leu Arg Asp Phe Pro Gly Arg Pro Met Gly His
65                  70                  75                  80  
Leu Ser Lys Asp Val Asp Glu Asn Asp Ser His Glu Gly Glu Asp Gln
                85                  90                  95      
Phe Leu Ser Leu Glu Ala Ser Thr Glu Thr Leu Val His Val Ser Asp
            100                 105                 110         
Glu Asp Asn Asn Ala Asp Leu Cys Leu Thr Asp Asp Lys Gln Val Leu
        115                 120                 125             
Asn Thr Gln Gly Gln Lys Thr Ser Gly Gln His Met Ile Gln Gly Ala
    130                 135                 140                 
Gly Ser Leu Glu Lys Ala Leu Pro Ile Ile Gln Ser Asn Gln Val Ser
145                 150                 155                 160 
Ser Asn Ser Trp Gly Ile Ala Gly Glu Thr Glu Leu Ala Leu Val Lys
                165                 170                 175     
Glu Ser Gly Glu Arg Lys Val Thr Asp Ser Ile Ser Lys Ser Leu Glu
            180                 185                 190         
Leu Cys Asn Glu Ile Ser Leu Ser Glu Ile Lys Asp Ala Pro Lys Val
        195                 200                 205             
Asn Ala Val Asp Thr Leu Asn Val Lys Asp Ile Ala Pro Glu Lys Gln
    210                 215                 220                 
Leu Leu Asn Ser Ala Val Ile Ala Gln Gln Arg Arg Lys Pro Asp Pro
225                 230                 235                 240 
Pro Lys Asp Glu Asn Glu Arg Ser Thr Cys Asn Val Val Gln Asp Glu
                245                 250                 255     
Phe Leu Asp Thr Pro Cys Thr Asn Arg Gly Leu Pro Leu Leu Lys Thr
            260                 265                 270         
Asp Phe Gly Ser Cys Leu Leu Gln Pro Pro Ser Cys Pro Asn Gly Met
        275                 280                 285             
Ser Ala Glu Asn Gly Leu Glu Lys Ser Gly Phe Ser Gln His Gln Asn
    290                 295                 300                 
Lys Ser Pro Pro Lys Val Lys Ala Glu Asp Gly Met Gln Cys Leu Gln
305                 310                 315                 320 
Leu Lys Glu Thr Leu Ala Thr Gln Glu Pro Thr Asp Asn Gln Val Arg
                325                 330                 335     
Leu Arg Lys Arg Lys Glu Ile Arg Glu Asp Arg Asp Arg Ala Arg Leu
            340                 345                 350         
Asp Ser Met Val Leu Leu Ile Met Lys Leu Asp Gln Leu Asp Gln Asp
        355                 360                 365             
Ile Glu Asn Ala Leu Ser Thr Ser Ser Ser Pro Ser Gly Thr Pro Thr
    370                 375                 380                 
Asn Leu Arg Arg His Val Pro Asp Leu Glu Ser Gly Ser Glu Ser Gly
385                 390                 395                 400 
Ala Asp Thr Ile Ser Val Asn Gln Thr Arg Val Asn Leu Ser Ser Asp
                405                 410                 415     
Thr Glu Ser Thr Asp Leu Pro Ser Ser Thr Pro Val Ala Asn Ser Gly
            420                 425                 430         
Thr Lys Pro Lys Thr Thr Ala Ile Gln Gly Ile Ser Glu Lys Glu Lys
        435                 440                 445             
Ala Glu Ile Glu Ala Lys Glu Ala Cys Asp Trp Leu Arg Ala Thr Gly
    450                 455                 460                 
Phe Pro Gln Tyr Ala Gln Leu Tyr Glu Asp Phe Leu Phe Pro Ile Asp
465                 470                 475                 480 
Ile Ser Leu Val Lys Arg Glu His Asp Phe Leu Asp Arg Asp Ala Ile
                485                 490                 495     
Glu Ala Leu Cys Arg Arg Leu Asn Thr Leu Asn Lys Cys Ala Val Met
            500                 505                 510         
Lys Leu Glu Ile Ser Pro His Arg Lys Arg Ser Asp Asp Ser Asp Glu
        515                 520                 525             
Asp Glu Pro Cys Ala Ile Ser Gly Lys Trp Thr Phe Gln Arg Asp Ser
    530                 535                 540                 
Lys Arg Trp Ser Arg Leu Glu Glu Phe Asp Val Phe Ser Pro Lys Gln
545                 550                 555                 560 
Asp Leu Val Pro Gly Ser Pro Asp Asp Ser His Pro Lys Asp Gly Pro
                565                 570                 575     
Ser Pro Gly Gly Thr Leu Met Asp Leu Ser Glu Arg Gln Glu Val Ser
            580                 585                 590         
Ser Val Arg Ser Leu Ser Ser Thr Gly Ser Leu Pro Ser His Ala Pro
        595                 600                 605             
Pro Ser Glu Asp Ala Ala Thr Pro Arg Thr Asn Ser Val Ile Ser Val
    610                 615                 620                 
Cys Ser Ser Ser Asn Leu Ala Gly Asn Asp Asp Ser Phe Gly Ser Leu
625                 630                 635                 640 
Pro Ser Pro Lys Glu Leu Ser Ser Phe Ser Phe Ser Met Lys Gly His
                645                 650                 655     
Glu Lys Thr Ala Lys Ser Lys Thr Arg Ser Leu Leu Lys Arg Met Glu
            660                 665                 670         
Ser Leu Lys Leu Lys Ser Ser His His Ser Lys His Lys Ala Pro Ser
        675                 680                 685             
Lys Leu Gly Leu Ile Ile Ser Gly Pro Ile Leu Gln Glu Gly Met Asp
    690                 695                 700                 
Glu Glu Lys Leu Lys Gln Leu Asn Cys Val Glu Ile Ser Ala Leu Asn
705                 710                 715                 720 
Gly Asn Arg Ile Asn Val Pro Met Val Arg Lys Arg Ser Val Ser Asn
                725                 730                 735     
Ser Thr Gln Thr Ser Ser Ser Ser Ser Gln Ser Glu Thr Ser Ser Ala
            740                 745                 750         
Val Ser Thr Pro Ser Pro Val Thr Arg Thr Arg Ser Leu Ser Ala Cys
        755                 760                 765             
Asn Lys Arg Val Gly Met Tyr Leu Glu Gly Phe Asp Pro Phe Asn Gln
    770                 775                 780                 
Ser Thr Phe Asn Asn Val Val Glu Gln Asn Phe Lys Asn Arg Glu Ser
785                 790                 795                 800 
Tyr Pro Glu Asp Thr Val Phe Tyr Ile Pro Glu Asp His Lys Pro Gly
                805                 810                 815     
Thr Phe Pro Lys Ala Leu Thr Asn Gly Ser Phe Ser Pro Ser Gly Asn
            820                 825                 830         
Asn Gly Ser Val Asn Trp Arg Thr Gly Ser Phe His Gly Pro Gly His
        835                 840                 845             
Ile Ser Leu Arg Arg Glu Asn Ser Ser Asp Ser Pro Lys Glu Leu Lys
    850                 855                 860                 
Arg Arg Asn Ser Ser Ser Ser Met Ser Ser Arg Leu Ser Ile Tyr Asp
865                 870                 875                 880 
Asn Val Pro Gly Ser Ile Leu Tyr Ser Ser Ser Gly Asp Leu Ala Asp
                885                 890                 895     
Leu Glu Asn Glu Asp Ile Phe Pro Glu Leu Asp Asp Ile Leu Tyr His
            900                 905                 910         
Val Lys Gly Met Gln Arg Ile Val Asn Gln Trp Ser Glu Lys Phe Ser
        915                 920                 925             
Asp Glu Gly Asp Ser Asp Ser Ala Leu Asp Ser Val Ser Pro Cys Pro
    930                 935                 940                 
Ser Ser Pro Lys Gln Ile His Leu Asp Val Asp Asn Asp Arg Thr Thr
945                 950                 955                 960 
Pro Ser Asp Leu Asp Ser Thr Gly Asn Ser Leu Asn Glu Pro Glu Glu
                965                 970                 975     
Pro Ser Glu Ile Pro Glu Arg Arg Asp Ser Gly Val Gly Ala Ser Leu
            980                 985                 990         
Thr Arg Ser Asn Arg His Arg Leu Arg Trp His Ser Phe Gln Ser Ser
        995                 1000                1005            
His Arg Pro Ser Leu Asn Ser Val Ser Leu Gln Ile Asn Cys Gln Ser
    1010                1015                1020                
Val Ala Gln Met Asn Leu Leu Gln Lys Tyr Ser Leu Leu Lys Leu Thr
1025                1030                1035                1040
Ala Leu Leu Glu Lys Tyr Thr Pro Ser Asn Lys His Gly Phe Ser Trp
                1045                1050                1055    
Ala Val Pro Lys Phe Met Lys Arg Ile Lys Val Pro Asp Tyr Lys Asp
            1060                1065                1070        
Arg Ser Val Phe Gly Val Pro Leu Thr Val Asn Val Gln Arg Thr Gly
        1075                1080                1085            
Gln Pro Leu Pro Gln Ser Ile Gln Gln Ala Met Arg Tyr Leu Arg Asn
    1090                1095                1100                
His Cys Leu Asp Gln Val Gly Leu Phe Arg Lys Ser Gly Val Lys Ser
1105                1110                1115                1120
Arg Ile Gln Ala Leu Arg Gln Met Asn Glu Gly Ala Ile Asp Cys Val
                1125                1130                1135    
Asn Tyr Glu Gly Gln Ser Ala Tyr Asp Val Ala Asp Met Leu Lys Gln
            1140                1145                1150        
Tyr Phe Arg Asp Leu Pro Glu Pro Leu Met Thr Asn Lys Leu Ser Glu
        1155                1160                1165            
Thr Phe Leu Gln Ile Tyr Gln Tyr Val Pro Lys Asp Gln Arg Leu Gln
    1170                1175                1180                
Ala Ile Lys Ala Ala Ile Met Leu Leu Pro Asp Glu Asn Arg Glu Val
1185                1190                1195                1200
Leu Gln Thr Leu Leu Tyr Phe Leu Ser Asp Val Thr Ala Ala Val Lys
                1205                1210                1215    
Glu Asn Gln Met Thr Pro Thr Asn Leu Ala Val Cys Leu Ala Pro Ser
            1220                1225                1230        
Leu Phe His Leu Asn Thr Leu Lys Arg Glu Asn Ser Ser Pro Arg Val
        1235                1240                1245            
Met Gln Arg Lys Gln Ser Leu Gly Lys Pro Asp Gln Lys Asp Leu Asn
    1250                1255                1260                
Glu Asn Leu Ala Ala Thr Gln Gly Leu Ala His Met Ile Ala Glu Cys
1265                1270                1275                1280
Lys Lys Leu Phe Gln Val Pro Glu Glu Met Ser Arg Cys Arg Asn Ser
                1285                1290                1295    
Tyr Thr Glu Gln Glu Leu Lys Pro Leu Thr Leu Glu Ala Leu Gly His
            1300                1305                1310        
Leu Gly Asn Asp Asp Ser Ala Asp Tyr Gln His Phe Leu Gln Asp Cys
        1315                1320                1325            
Val Asp Gly Leu Phe Lys Glu Val Lys Glu Lys Phe Lys Gly Trp Val
    1330                1335                1340                
Ser Tyr Ser Thr Ser Glu Gln Ala Glu Leu Ser Tyr Lys Lys Val Ser
1345                1350                1355                1360
Glu Gly Pro Pro Leu Arg Leu Trp Arg Ser Val Ile Glu Val Pro Ala
                1365                1370                1375    
Val Pro Glu Glu Ile Leu Lys Arg Leu Leu Lys Glu Gln His Leu Trp
            1380                1385                1390        
Asp Val Asp Leu Leu Asp Ser Lys Val Ile Glu Ile Leu Asp Ser Gln
        1395                1400                1405            
Thr Glu Ile Tyr Gln Tyr Val Gln Asn Ser Met Ala Pro His Pro Ala
    1410                1415                1420                
Arg Asp Tyr Val Val Leu Arg Thr Trp Arg Thr Asn Leu Pro Lys Gly
1425                1430                1435                1440
Ala Cys Ala Leu Leu Leu Thr Ser Val Asp His Asp Arg Ala Pro Val
                1445                1450                1455    
Val Gly Val Arg Val Asn Val Leu Leu Ser Arg Tyr Leu Ile Glu Pro
            1460                1465                1470        
Cys Gly Pro Gly Lys Ser Lys Leu Thr Tyr Met Cys Arg Val Asp Leu
        1475                1480                1485            
Arg Gly His Met Pro Glu Trp Tyr Thr Lys Ser Phe Gly His Leu Cys
    1490                1495                1500                
Ala Ala Glu Val Val Lys Ile Arg Asp Ser Phe Ser Asn Gln Asn Thr
1505                1510                1515                1520
Glu Thr Lys Asp Thr Lys Ser Arg
                1525            


<210> 8473
<211> 459
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 25
<223> Xaa = Any Amino Acid

<400> 8473
Met Ala Ser Arg Asp Pro Thr Gly Leu Ser Arg Pro Cys Thr Ile Asn
 1               5                  10                  15      
Leu Thr Gln Glu Asp Met Glu Glu Xaa Gln Ala Phe Lys Arg Ser Arg
            20                  25                  30          
Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu Leu Gln Thr Lys Asn
        35                  40                  45              
Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn Ile Lys Ala Leu Arg
    50                  55                  60                  
Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp Ser Ser Gly Pro Glu
65                  70                  75                  80  
His Ile Leu Ser Ile Ser Ala Gly Ile Asp Thr Ile Gly Glu Ile Leu
                85                  90                  95      
Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu Gln Phe Pro Ser Pro
            100                 105                 110         
Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Val Ala Val Glu Cys Leu
        115                 120                 125             
Ser Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp Cys Glu Leu Arg Leu
    130                 135                 140                 
Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile Gly Val Glu Gly Ala
145                 150                 155                 160 
Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr Thr Ile Lys Leu Phe
                165                 170                 175     
Gln Glu Cys Cys Pro Tyr Ser Thr Asp Arg Val Val Leu Ile Gly Gly
            180                 185                 190         
Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile Ile Leu Asp Leu Ile
        195                 200                 205             
Tyr Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro Tyr Asp Pro Asn Phe
    210                 215                 220                 
Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr Ile Met Phe Asp Asp
225                 230                 235                 240 
Arg Cys Gly Arg Pro Val Gly Phe Pro Met Arg Gly Arg Gly Gly Phe
                245                 250                 255     
Asp Arg Met Pro Pro Gly Gln Gly Gly Arg Pro Met Pro Pro Ser Arg
            260                 265                 270         
Arg Asp Tyr Asp Asp Met Ser Pro Arg Gln Gly Pro Pro Pro Pro Pro
        275                 280                 285             
Pro Gly Gln Gly Gly Glu Gly Gly Ser Arg Ala Arg Asn Leu Pro Leu
    290                 295                 300                 
Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu Met Ala Tyr Asp Arg
305                 310                 315                 320 
Arg Gly Arg Pro Gly Asp Cys Tyr His Gly Met Val Gly Phe Ser Ala
                325                 330                 335     
Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp Ser Pro Ser Glu Trp
            340                 345                 350         
Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Arg Tyr Asp Tyr Ser Tyr
        355                 360                 365             
Ala Gly Gly Arg Gly Ser Tyr Gly Asn Leu Gly Gly Leu Ile Ile Thr
    370                 375                 380                 
Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly Ser Ile Ile Gly Lys
385                 390                 395                 400 
Gly Gly Leu Gln Ile Lys Gln Ile Arg His Glu Ser Gly Ala Ser Ile
                405                 410                 415     
Lys Ile Asp Glu Pro Leu Glu Gly Leu Glu Asp Trp Ile Ile Thr Ile
            420                 425                 430         
Arg Glu Thr Gln Asp Gln Ile Gln Asn Ala Gln Tyr Leu Leu Gln Asn
        435                 440                 445             
Ser Val Lys Gln Cys Ala Asp Val Glu Gly Val
    450                 455                 


<210> 8474
<211> 1037
<212> PRT
<213> Homo sapiens

<400> 8474
Met Val Ala Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys
 1               5                  10                  15      
Pro Phe Val Leu Arg Ser Lys Met Gly Lys Trp Cys Arg His Cys Phe
            20                  25                  30          
Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp
        35                  40                  45              
Gln Asp Asp Ser Thr Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp
    50                  55                  60                  
Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val
65                  70                  75                  80  
Gly Thr Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser
                85                  90                  95      
Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser
            100                 105                 110         
Gly Lys Ser Asn Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe
        115                 120                 125             
Val Glu Pro Arg Tyr His Val Arg Arg Glu Asp Leu Asp Lys Leu His
    130                 135                 140                 
Arg Ala Ala Trp Trp Gly Lys Val Ala Arg Lys Asp Leu Ile Val Met
145                 150                 155                 160 
Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Ser Ala Leu
                165                 170                 175     
Gln Phe Pro Lys Lys Ser Cys His Ser His Arg Thr Ala Leu His Leu
            180                 185                 190         
Ala Ser Ala Asn Gly Asn Ser Gly Val Val Lys Leu Leu Leu Asp Arg
        195                 200                 205             
Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr Ala Leu Thr
    210                 215                 220                 
Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met Leu Leu Glu
225                 230                 235                 240 
His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn Thr Thr Leu
                245                 250                 255     
His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys Ala Leu Leu
            260                 265                 270         
Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly Leu Thr Pro
        275                 280                 285             
Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val Lys Phe Leu
    290                 295                 300                 
Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr Gly Arg Thr
305                 310                 315                 320 
Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile Val Ser Leu
                325                 330                 335     
Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu Ser Gly Gln
            340                 345                 350         
Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val Ile Cys Gln
        355                 360                 365             
Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile Ser Ser Glu
    370                 375                 380                 
Asn Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu Glu Glu Ser
385                 390                 395                 400 
Gln Arg Gly Lys Asn Lys Phe Gln Asn Phe Val Leu Leu Phe Leu Gln
                405                 410                 415     
His Pro Asn Met Met Lys Lys Val Glu Glu Glu Met Lys Lys His Glu
            420                 425                 430         
Ser Asn Asn Val Gly Leu Leu Glu Asn Leu Ser Asn Gly Val Thr Ala
        435                 440                 445             
Gly Asn Gly Asp Asp Gly Leu Ile Pro Gln Arg Lys Ser Arg Thr Pro
    450                 455                 460                 
Glu Asn Gln Gln Phe Pro Asp Asn Glu Ser Glu Glu Tyr His Arg Ile
465                 470                 475                 480 
Cys Glu Leu Val Ser Asp Tyr Lys Glu Lys Gln Met Pro Lys Tyr Ser
                485                 490                 495     
Ser Glu Asn Ser Asn Pro Glu Met Lys Lys His Gly Ser Thr His Val
            500                 505                 510         
Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala Thr Ala Gly Asn Gly Asp
        515                 520                 525             
Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg Thr Pro Glu Ser Gln Gln
    530                 535                 540                 
Phe Pro Asp Thr Glu Asn Glu Glu Tyr His Ser Asp Glu Gln Asn Asp
545                 550                 555                 560 
Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn Thr Gly Ile Leu His Asp
                565                 570                 575     
Glu Ile Leu Ile His Glu Glu Lys Gln Ile Glu Val Val Glu Lys Met
            580                 585                 590         
Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys Glu Lys Asp Phe Leu His
        595                 600                 605             
Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala Met Leu Arg Leu Glu Leu
    610                 615                 620                 
Asp Thr Met Lys His Gln Ser Gln Leu Arg Lys Lys Lys Tyr Leu Glu
625                 630                 635                 640 
Asp Ile Glu Ser Val Lys Lys Lys Asn Asp Asn Leu Leu Lys Ala Leu
                645                 650                 655     
Gln Leu Asn Glu Leu Thr Met Asp Asp Asp Thr Ala Val Leu Val Ile
            660                 665                 670         
Asp Asn Gly Ser Gly Met Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala
        675                 680                 685             
Pro Arg Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg Gln Gln Gly
    690                 695                 700                 
Met Met Gly Gly Met His Gln Lys Glu Ser Tyr Val Gly Lys Glu Ala
705                 710                 715                 720 
Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys Tyr Pro Met Glu His Gly
                725                 730                 735     
Ile Ile Thr Asn Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe
            740                 745                 750         
Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Ile Leu Leu Thr
        755                 760                 765             
Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile
    770                 775                 780                 
Met Phe Glu Thr Phe Asn Thr Pro Ala Met Tyr Val Ala Ile Gln Ala
785                 790                 795                 800 
Met Leu Ser Leu Tyr Thr Ser Gly Arg Thr Thr Gly Ile Val Met Asp
                805                 810                 815     
Ser Gly Asp Gly Val Thr His Thr Val Pro Ile Tyr Asp Gly Asn Ala
            820                 825                 830         
Leu Pro His Ala Thr Leu Arg Leu Asp Leu Ala Gly Arg Glu Leu Thr
        835                 840                 845             
Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Arg Phe Thr Thr
    850                 855                 860                 
Met Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr
865                 870                 875                 880 
Val Ala Leu Asp Phe Glu Gln Glu Met Ala Met Ala Ala Ser Ser Ser
                885                 890                 895     
Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile
            900                 905                 910         
Gly Asn Glu Trp Phe Arg Cys Pro Glu Ala Leu Phe Gln Pro Cys Phe
        915                 920                 925             
Leu Gly Met Glu Ser Cys Gly Ile His Glu Thr Thr Phe Asn Ser Ile
    930                 935                 940                 
Met Lys Ser Asp Val Asp Ile Arg Lys Asp Leu Tyr Thr Asn Thr Val
945                 950                 955                 960 
Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Met Ala His Arg Met Gln
                965                 970                 975     
Lys Glu Ile Ala Ala Leu Ala Pro Ser Met Leu Lys Ile Arg Ile Ile
            980                 985                 990         
Ala Pro Pro Lys Arg Lys Tyr Ser Val Trp Val Gly Gly Ser Ile Leu
        995                 1000                1005            
Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr
    1010                1015                1020                
Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys Cys Phe
1025                1030                1035        


<210> 8475
<211> 685
<212> PRT
<213> Homo sapiens

<400> 8475
Met Val Ala Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys
 1               5                  10                  15      
Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys His Cys Phe
            20                  25                  30          
Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp
        35                  40                  45              
Arg Asn Asp Ser Ser Val Lys Thr Leu Gly Ser Lys Arg Cys Lys Trp
    50                  55                  60                  
Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val
65                  70                  75                  80  
Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe Met Asp Pro Arg Tyr
                85                  90                  95      
His Val His Gly Glu Asp Leu Asp Lys Leu His Arg Ala Ala Trp Trp
            100                 105                 110         
Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met Leu Arg Asp Thr Asp
        115                 120                 125             
Val Asn Lys Arg Asp Lys Gln Lys Arg Thr Ala Leu His Leu Ala Ser
    130                 135                 140                 
Ala Asn Gly Asn Ser Glu Val Val Lys Leu Val Leu Asp Arg Arg Cys
145                 150                 155                 160 
Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr Ala Leu Thr Lys Val
                165                 170                 175     
Cys Ser Ser Gln Leu Tyr Gln Arg Glu Ala Val Gln Cys Gln Glu Asp
            180                 185                 190         
Glu Cys Ala Leu Met Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro
        195                 200                 205             
Asp Glu Tyr Gly Asn Thr Thr Leu His Tyr Ala Val Tyr Asn Glu Asp
    210                 215                 220                 
Lys Leu Met Ala Lys Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser
225                 230                 235                 240 
Lys Asn Lys Leu Ser Leu Ser Tyr Lys Lys Glu Lys Asp Phe Leu His
                245                 250                 255     
Glu Asn Ser Thr Leu Gln Glu Glu Val Ala Met Leu Arg Leu Glu Leu
            260                 265                 270         
Asp Ile Met Lys His Gln Ser Gln Leu Arg Glu Lys Lys Tyr Leu Glu
        275                 280                 285             
Glu Ile Glu Ser Val Glu Lys Lys Asn Asp Asn Leu Leu Lys Ala Leu
    290                 295                 300                 
Gln Leu Asn Glu Leu Thr Met Asp Asp Asp Thr Ala Val Leu Val Ile
305                 310                 315                 320 
Asp Asn Gly Ser Gly Met Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala
                325                 330                 335     
Pro Gln Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly
            340                 345                 350         
Met Met Glu Gly Met His Gln Lys Glu Ser Tyr Val Gly Lys Glu Ala
        355                 360                 365             
Gln Ser Lys Arg Gly Met Leu Thr Leu Lys Tyr Pro Met Glu His Gly
    370                 375                 380                 
Ile Ile Thr Asn Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe
385                 390                 395                 400 
Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Ile Leu Leu Thr
                405                 410                 415     
Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile
            420                 425                 430         
Met Phe Glu Thr Phe Asn Thr Pro Ala Met Tyr Val Ala Ile Gln Ala
        435                 440                 445             
Val Leu Ser Leu Tyr Thr Ser Gly Arg Thr Thr Gly Ile Val Met Asp
    450                 455                 460                 
Ser Gly Asp Gly Phe Thr His Thr Val Pro Ile Tyr Glu Gly Asn Ala
465                 470                 475                 480 
Leu Pro His Ala Thr Leu Arg Leu Asp Leu Ala Gly Arg Glu Leu Thr
                485                 490                 495     
Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Arg Phe Thr Thr
            500                 505                 510         
Thr Ala Glu Gln Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr
        515                 520                 525             
Val Ala Leu Asp Ser Glu Gln Glu Met Ala Met Ala Ala Ser Ser Ser
    530                 535                 540                 
Ser Val Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile
545                 550                 555                 560 
Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala Leu Phe Gln Pro Cys Phe
                565                 570                 575     
Leu Gly Met Glu Ser Cys Gly Ile His Lys Thr Thr Phe Asn Ser Ile
            580                 585                 590         
Val Lys Ser Asp Val Asp Ile Arg Lys Asp Leu Tyr Thr Asn Thr Val
        595                 600                 605             
Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Ile Ala His Arg Met Gln
    610                 615                 620                 
Lys Glu Ile Thr Ala Leu Ala Pro Ser Ile Met Lys Ile Lys Ile Ile
625                 630                 635                 640 
Ala Pro Pro Lys Arg Lys Tyr Ser Val Trp Val Gly Gly Ser Ile Leu
                645                 650                 655     
Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr
            660                 665                 670         
Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys Cys Phe
        675                 680                 685 


<210> 8476
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 8476
Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys
 1               5                  10                  15      
Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe
            20                  25                  30          
Pro Cys Tyr Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp
        35                  40                  45              
His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp
    50                  55                  60                  
Cys His His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val
65                  70                  75                  80  
Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn
                85                  90                  95      
Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser
            100                 105                 110         
Gly Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe
        115                 120                 125             
Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His
    130                 135                 140                 
Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met
145                 150                 155                 160 
Leu Arg Asp Thr Asp Val Asn Lys Lys Asp Lys Gln Lys Arg Pro His
                165                 170                 175     
Thr Thr Leu Asp Val Glu Thr Ser Glu Arg Thr Ala Leu His Leu Ala
            180                 185                 190         
Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu Leu Asp Arg Arg
        195                 200                 205             
Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr Ala Leu Ile Lys
    210                 215                 220                 
Val Cys Ser Ser Gln Leu Tyr Gln His Glu Ala Val Gln Cys Gln Glu
225                 230                 235                 240 
Asp Glu Cys Ala Leu Met Leu Leu Glu His Gly Thr Asp Pro Asn Ile
                245                 250                 255     
Pro Asp Glu Tyr Gly Asn Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu
            260                 265                 270         
Asp Lys Leu Met Ala Lys Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu
        275                 280                 285             
Ser Lys Asn Lys His Gly Leu Thr Pro Leu Leu Leu Gly Val His Glu
    290                 295                 300                 
Gln Lys Gln Gln Val Val Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu
305                 310                 315                 320 
Asn Ala Leu Asp Arg Tyr Gly Arg Thr Ala Leu Ile Leu Ala Val Cys
                325                 330                 335     
Cys Gly Ser Ala Ser Ile Val Ser Leu Leu Leu Glu Gln Asn Ile Asp
            340                 345                 350         
Val Ser Ser Gln Asp Leu Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val
        355                 360                 365             
Ser Ser His His His Val Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu
    370                 375                 380                 
Lys Gln Met Leu Lys Ile Ser Ser Glu Asn Ser Asn Pro Val Ile Thr
385                 390                 395                 400 
Ile Leu Asn Ile Pro Leu Lys Val Glu Glu Glu Met Lys Lys His Glu
                405                 410                 415     
Ser Asn Asn Val Gly Leu Leu Glu Asn Leu Thr Asn Gly Val Thr Ala
            420                 425                 430         
Gly Asn Gly Asp Asn Gly Leu Ile Pro Gln Arg Lys Ser Arg Thr Pro
        435                 440                 445             
Glu Asn Gln Gln Phe Pro Asp Asn Glu Ser Glu Glu Tyr His Arg Ile
    450                 455                 460                 
Cys Glu Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Pro Lys Tyr Ser
465                 470                 475                 480 
Ser Glu Asn Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu Glu
                485                 490                 495     
Glu Ser Gln Arg Leu Lys Gly Lys Met Lys Lys His Gly Ser Thr His
            500                 505                 510         
Val Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala Thr Ala Gly Asn Gly
        515                 520                 525             
Asp Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg Thr Pro Glu Ser Gln
    530                 535                 540                 
Gln Phe Pro Asp Thr Glu Asn Glu Glu Tyr His Ser Asp Glu Gln Asn
545                 550                 555                 560 
Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn Thr Gly Ile Leu His
                565                 570                 575     
Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile Glu Val Val Glu Lys
            580                 585                 590         
Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys Glu Lys Asp Val Leu
        595                 600                 605             
His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala Met Leu Arg Leu Glu
    610                 615                 620                 
Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg Glu Lys Lys Tyr Leu
625                 630                 635                 640 
Glu Asp Ile Glu Ser Val Lys Lys Lys Asn Asp Asn Leu Leu Lys Ala
                645                 650                 655     
Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp Thr Ala Val Leu Val
            660                 665                 670         
Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly Phe Ala Gly Asp Asp
        675                 680                 685             
Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg Gln Gln
    690                 695                 700                 
Gly Met Met Gly Gly Met His Gln Lys Glu Ser Tyr Val Gly Lys Glu
705                 710                 715                 720 
Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys Tyr Pro Met Glu His
                725                 730                 735     
Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys Ile Trp His His Thr
            740                 745                 750         
Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Ile Leu Leu
        755                 760                 765             
Thr Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln
    770                 775                 780                 
Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met Tyr Val Ala Ile Gln
785                 790                 795                 800 
Ala Val Pro Ser Leu Tyr Thr Ser Gly Arg Thr Thr Gly Ile Val Met
                805                 810                 815     
Asp Ser Gly Asp Gly Val Thr His Thr Val Pro Ile Tyr Glu Gly Asn
            820                 825                 830         
Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu Ala Gly Arg Glu Leu
        835                 840                 845             
Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Arg Phe Thr
    850                 855                 860                 
Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys
865                 870                 875                 880 
Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala Thr Ala Ala Ser Ser
                885                 890                 895     
Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr
            900                 905                 910         
Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala Leu Phe Gln Pro Cys
        915                 920                 925             
Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu Thr Thr Phe Asn Ser
    930                 935                 940                 
Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp Leu Tyr Thr Asn Thr
945                 950                 955                 960 
Val Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Met Ala His Arg Met
                965                 970                 975     
Gln Lys Glu Ile Ala Ala Leu Ala Pro Ser Met Met Lys Ile Arg Ile
            980                 985                 990         
Ile Ala Pro Pro Lys Arg Lys Tyr Ser Val Trp Val Gly Gly Ser Ile
        995                 1000                1005            
Leu Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu
    1010                1015                1020                
Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys Cys Phe
1025                1030                1035            


<210> 8477
<211> 960
<212> PRT
<213> Homo sapiens

<400> 8477
Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys
 1               5                  10                  15      
Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe
            20                  25                  30          
Pro Cys Cys Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp
        35                  40                  45              
His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp
    50                  55                  60                  
Cys Arg His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val
65                  70                  75                  80  
Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn
                85                  90                  95      
Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser
            100                 105                 110         
Ser Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe
        115                 120                 125             
Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His
    130                 135                 140                 
Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met
145                 150                 155                 160 
Leu Arg Asp Thr Asp Val Asn Lys Gln Asp Lys Gln Lys Arg Pro His
                165                 170                 175     
Thr Thr Leu Asp Val Glu Thr Ser Glu Arg Thr Ala Leu His Leu Ala
            180                 185                 190         
Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu Leu Asp Arg Arg
        195                 200                 205             
Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr Ala Leu Ile Lys
    210                 215                 220                 
Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met Leu Leu Glu His
225                 230                 235                 240 
Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn Thr Thr Leu His
                245                 250                 255     
Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys Ala Leu Leu Leu
            260                 265                 270         
Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly Leu Thr Pro Leu
        275                 280                 285             
Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val Lys Phe Leu Ile
    290                 295                 300                 
Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr Gly Arg Thr Ala
305                 310                 315                 320 
Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile Val Ser Leu Leu
                325                 330                 335     
Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu Ser Gly Gln Thr
            340                 345                 350         
Ala Arg Glu Tyr Ala Val Ser Ser His His His Val Ile Cys Gln Leu
        355                 360                 365             
Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile Ser Ser Glu Asn
    370                 375                 380                 
Ser Asn Pro Glu Gln Asp Leu Lys Leu Thr Ser Glu Glu Glu Ser Gln
385                 390                 395                 400 
Arg Gly Lys Asn Lys Leu Gln Asn Phe Val Leu Leu Phe Leu Gln His
                405                 410                 415     
Pro Asn Met Met Lys Lys Val Glu Glu Glu Met Lys Lys His Glu Ser
            420                 425                 430         
Asn Asn Val Gly Leu Leu Glu Asn Leu Thr Asn Gly Val Thr Ala Gly
        435                 440                 445             
Asn Gly Asp Asn Gly Leu Ile Pro Gln Arg Lys Ser Arg Thr Pro Glu
    450                 455                 460                 
Asn Gln Gln Phe Pro Asp Asn Glu Ser Glu Glu Tyr His Ser Asp Glu
465                 470                 475                 480 
Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn Thr Gly Ile
                485                 490                 495     
Leu His Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile Glu Val Val
            500                 505                 510         
Glu Lys Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys Glu Lys Asp
        515                 520                 525             
Ile Leu His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala Met Leu Arg
    530                 535                 540                 
Leu Glu Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg Glu Lys Lys
545                 550                 555                 560 
Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys Arg Asn Asp Asn Leu Leu
                565                 570                 575     
Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp Thr Ala Val
            580                 585                 590         
Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly Phe Ala Gly
        595                 600                 605             
Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg
    610                 615                 620                 
Gln Gln Gly Met Met Gly Gly Met His Gln Lys Glu Ser Tyr Val Gly
625                 630                 635                 640 
Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys Tyr Pro Met
                645                 650                 655     
Glu His Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys Ile Trp His
            660                 665                 670         
His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Val
        675                 680                 685             
Leu Leu Thr Glu Ala Thr Leu Asn Pro Lys Ala Asn Arg Glu Lys Met
    690                 695                 700                 
Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met Tyr Val Ala
705                 710                 715                 720 
Ile Gln Ala Val Leu Ser Leu Tyr Thr Ser Gly Arg Thr Thr Gly Ile
                725                 730                 735     
Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro Ile Tyr Glu
            740                 745                 750         
Gly Asn Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu Ala Gly Arg
        755                 760                 765             
Glu Leu Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu His Gly Tyr Arg
    770                 775                 780                 
Phe Thr Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys
785                 790                 795                 800 
Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala Thr Val Ala
                805                 810                 815     
Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val
            820                 825                 830         
Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala Leu Phe Gln
        835                 840                 845             
Pro Cys Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu Thr Thr Phe
    850                 855                 860                 
Asn Ser Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp Leu Tyr Thr
865                 870                 875                 880 
Asn Thr Val Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Met Ala His
                885                 890                 895     
Arg Met Gln Lys Glu Ile Ala Ala Leu Ala Pro Ser Met Met Lys Ile
            900                 905                 910         
Arg Ile Ile Ala Pro Pro Lys Arg Lys Tyr Ser Val Trp Val Gly Gly
        915                 920                 925             
Ser Ile Leu Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys
    930                 935                 940                 
Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys Cys Leu
945                 950                 955                 960 


<210> 8478
<211> 534
<212> PRT
<213> Homo sapiens

<400> 8478
Met Lys Lys His Gly Ser Thr His Val Gly Phe Pro Glu Asn Leu Thr
 1               5                  10                  15      
Asn Gly Ala Thr Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro Pro Arg
            20                  25                  30          
Lys Ser Arg Thr Pro Glu Ser Gln Gln Phe Pro Asp Thr Glu Asn Glu
        35                  40                  45              
Glu Tyr His Ser Asp Glu Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu
    50                  55                  60                  
Glu Gln Asn Thr Gly Ile Leu His Asp Glu Ile Leu Ile His Glu Glu
65                  70                  75                  80  
Lys Gln Ile Glu Val Val Glu Lys Met Asn Ser Glu Leu Ser Leu Ser
                85                  90                  95      
Cys Lys Lys Glu Lys Asp Phe Leu His Glu Asn Ser Thr Leu Arg Glu
            100                 105                 110         
Glu Ile Ala Met Leu Arg Leu Glu Leu Asp Thr Met Lys His Gln Ser
        115                 120                 125             
Gln Leu Arg Lys Lys Lys Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys
    130                 135                 140                 
Lys Asn Asp Asn Leu Leu Lys Ala Leu Gln Leu Asn Glu Leu Thr Met
145                 150                 155                 160 
Asp Asp Asp Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met Cys
                165                 170                 175     
Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser
            180                 185                 190         
Ile Val Gly Arg Pro Arg Gln Gln Gly Met Met Gly Gly Met His Gln
        195                 200                 205             
Lys Glu Ser Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu
    210                 215                 220                 
Thr Leu Lys Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp Asp
225                 230                 235                 240 
Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala
                245                 250                 255     
Pro Glu Glu His Pro Ile Leu Leu Thr Glu Ala Pro Leu Asn Pro Lys
            260                 265                 270         
Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr
        275                 280                 285             
Pro Ala Met Tyr Val Ala Ile Gln Ala Met Leu Ser Leu Tyr Thr Ser
    290                 295                 300                 
Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His
305                 310                 315                 320 
Thr Val Pro Ile Tyr Asp Gly Asn Ala Leu Pro His Ala Thr Leu Arg
                325                 330                 335     
Leu Asp Leu Ala Gly Arg Glu Leu Thr Asp Tyr Leu Met Lys Ile Leu
            340                 345                 350         
Thr Glu Arg Gly Tyr Arg Phe Thr Thr Met Ala Glu Arg Glu Ile Val
        355                 360                 365             
Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln
    370                 375                 380                 
Glu Met Ala Met Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu
385                 390                 395                 400 
Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Trp Phe Arg Cys
                405                 410                 415     
Pro Glu Ala Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys Gly
            420                 425                 430         
Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Ser Asp Val Asp Ile
        435                 440                 445             
Arg Lys Asp Leu Tyr Thr Asn Thr Val Leu Ser Gly Gly Thr Thr Met
    450                 455                 460                 
Tyr Pro Gly Met Ala His Arg Met Gln Lys Glu Ile Ala Ala Leu Ala
465                 470                 475                 480 
Pro Ser Met Leu Lys Ile Arg Ile Ile Ala Pro Pro Lys Arg Lys Tyr
                485                 490                 495     
Ser Val Trp Val Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe Gln
            500                 505                 510         
Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile
        515                 520                 525             
Val His Arg Lys Cys Phe
    530                 


<210> 8479
<211> 370
<212> PRT
<213> Homo sapiens

<400> 8479
Met Lys Ile Lys Asp Ala Lys Lys Pro Ser Phe Pro Trp Phe Gly Met
 1               5                  10                  15      
Asp Ile Gly Gly Thr Leu Val Lys Leu Ser Tyr Phe Glu Pro Ile Asp
            20                  25                  30          
Ile Thr Ala Glu Glu Glu Gln Glu Glu Val Glu Ser Leu Lys Ser Ile
        35                  40                  45              
Arg Lys Tyr Leu Thr Ser Asn Val Ala Tyr Gly Ser Thr Gly Ile Arg
    50                  55                  60                  
Asp Val His Leu Glu Leu Lys Asp Leu Thr Leu Phe Gly Arg Arg Gly
65                  70                  75                  80  
Asn Leu His Phe Ile Arg Phe Pro Thr Gln Asp Leu Pro Thr Phe Ile
                85                  90                  95      
Gln Met Gly Arg Asp Lys Asn Phe Ser Thr Leu Gln Thr Val Leu Cys
            100                 105                 110         
Ala Thr Gly Gly Gly Ala Tyr Lys Phe Glu Lys Asp Phe Arg Thr Ile
        115                 120                 125             
Gly Asn Leu His Leu His Lys Leu Asp Glu Leu Asp Cys Leu Val Lys
    130                 135                 140                 
Gly Leu Leu Tyr Ile Asp Ser Val Ser Phe Asn Gly Gln Ala Glu Cys
145                 150                 155                 160 
Tyr Tyr Phe Ala Asn Ala Ser Glu Pro Glu Arg Cys Gln Lys Met Pro
                165                 170                 175     
Phe Asn Leu Asp Asp Pro Tyr Pro Leu Leu Val Val Asn Ile Gly Ser
            180                 185                 190         
Gly Val Ser Ile Leu Ala Val His Ser Lys Asp Asn Tyr Lys Arg Val
        195                 200                 205             
Thr Gly Thr Ser Leu Gly Gly Gly Thr Phe Leu Gly Leu Cys Ser Leu
    210                 215                 220                 
Leu Thr Gly Cys Glu Ser Phe Glu Glu Ala Leu Glu Met Ala Ser Lys
225                 230                 235                 240 
Gly Asp Ser Thr Gln Ala Asp Lys Leu Val Arg Asp Ile Tyr Gly Gly
                245                 250                 255     
Asp Tyr Glu Arg Phe Gly Leu Pro Gly Trp Ala Val Ala Ser Ser Phe
            260                 265                 270         
Gly Asn Met Ile Tyr Lys Glu Lys Arg Glu Ser Val Ser Lys Glu Asp
        275                 280                 285             
Leu Ala Arg Ala Thr Leu Val Thr Ile Thr Asn Asn Ile Gly Ser Val
    290                 295                 300                 
Ala Arg Met Cys Ala Val Asn Glu Lys Ile Asn Arg Val Val Phe Val
305                 310                 315                 320 
Gly Asn Phe Leu Arg Val Asn Thr Leu Ser Met Lys Leu Leu Ala Tyr
                325                 330                 335     
Ala Leu Asp Tyr Trp Ser Lys Gly Gln Leu Lys Ala Leu Phe Leu Glu
            340                 345                 350         
His Glu Gly Tyr Phe Gly Ala Val Gly Ala Leu Leu Gly Leu Pro Asn
        355                 360                 365             
Phe Ser
    370 


<210> 8480
<211> 289
<212> PRT
<213> Homo sapiens

<400> 8480
Met Arg Gly Thr Glu Cys Pro Gly Leu Val Asn Tyr Gln Ile Ser Val
 1               5                  10                  15      
Lys Cys Ser Asn Gln Phe Lys Leu Glu Val Cys Leu Leu Asn Ala Glu
            20                  25                  30          
Asn Lys Val Val Asp Asn Gln Ala Gly Thr Gln Gly Gln Leu Lys Val
        35                  40                  45              
Leu Gly Ala Asn Leu Trp Trp Pro Tyr Leu Met His Glu His Pro Ala
    50                  55                  60                  
Tyr Leu Tyr Ser Trp Glu Gly Arg Pro Asp Gly Ala Gln Ala Val Gly
65                  70                  75                  80  
Ala Leu Thr Ala Gly Thr Leu Ala Val Val Gly Val Ala Asp Cys Thr
                85                  90                  95      
Glu Val Thr Gly Ala Phe Asp Phe Tyr Thr Leu Pro Val Gly Leu Arg
            100                 105                 110         
Thr Val Ala Val Thr Glu Ser Gln Phe Leu Ile Ser Gly Lys Pro Phe
        115                 120                 125             
Tyr Phe His Gly Val Asn Lys His Glu Asp Ala Asp Ile Gln Gly Lys
    130                 135                 140                 
Gly Phe Asp Cys Pro Leu Leu Val Lys Asp Phe Asn Leu Leu Cys Trp
145                 150                 155                 160 
Leu Gly Ala Asn Thr Phe Cys Pro Ser His Tyr Pro Tyr Thr Glu Glu
                165                 170                 175     
Met Leu Gln Ile Cys Tyr Arg Tyr Gly Ile Val Val Ile Asp Glu Cys
            180                 185                 190         
Pro Ala Pro Ile His Ser Cys Val Gln Glu Leu Phe Gln Glu Val Asn
        195                 200                 205             
Leu Ile Phe Gly Ser Val Gln Ser Ser Asp Leu Ser Cys Val Tyr Leu
    210                 215                 220                 
Ala Gly Trp Leu Arg Leu Trp Gly Asn Trp Ile Gln Arg Met Val Ile
225                 230                 235                 240 
Ala His Thr Lys Ala Leu Asp Pro Ser Gln Pro Val Thr Phe Val Thr
                245                 250                 255     
Asn Ser Thr Tyr Ala Ala Asp Lys Gly Val Asn Lys Glu His Gln Lys
            260                 265                 270         
Phe Ser Val Phe Gly Lys Tyr Arg Glu Glu Asn Ile Leu Thr Lys Leu
        275                 280                 285             
Ser
    


<210> 8481
<211> 2073
<212> PRT
<213> Homo sapiens

<400> 8481
Met Asp Glu Leu Asp Gln Asp Gln His Gly Arg Leu Lys Asp Leu Phe
 1               5                  10                  15      
Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu Leu
            20                  25                  30          
Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val Leu
        35                  40                  45              
Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe Asp
    50                  55                  60                  
Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser Asn
65                  70                  75                  80  
Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro Lys
                85                  90                  95      
Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu Phe
            100                 105                 110         
Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro Leu
        115                 120                 125             
Asp Glu Glu Ala Arg Ala Ser His Ile Pro Ala Gly Asp Cys Ser Glu
    130                 135                 140                 
His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln Leu
145                 150                 155                 160 
Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser Ser
                165                 170                 175     
Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu Asp
            180                 185                 190         
Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val Ser
        195                 200                 205             
Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu Glu
    210                 215                 220                 
Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu Asp
225                 230                 235                 240 
Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser Ala
                245                 250                 255     
Ser Thr Pro Tyr Arg Gln Thr Lys Lys Ala Pro Phe Ser Met Gln Ser
            260                 265                 270         
Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser
        275                 280                 285             
Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His
    290                 295                 300                 
Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu
305                 310                 315                 320 
Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn
                325                 330                 335     
Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Tyr Glu Leu Leu Val
            340                 345                 350         
Thr Lys Asn Ser Thr His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu
        355                 360                 365             
Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu
    370                 375                 380                 
Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met
385                 390                 395                 400 
Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu
                405                 410                 415     
Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala
            420                 425                 430         
Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala
        435                 440                 445             
Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr
    450                 455                 460                 
Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn
465                 470                 475                 480 
Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Asn Val Leu Ala
                485                 490                 495     
Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu Gln
            500                 505                 510         
Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys Arg
        515                 520                 525             
Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu Tyr
    530                 535                 540                 
Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro Ser
545                 550                 555                 560 
Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly Leu
                565                 570                 575     
Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu Leu
            580                 585                 590         
Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys Leu
        595                 600                 605             
Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu Asp
    610                 615                 620                 
Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln Arg
625                 630                 635                 640 
His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu Lys
                645                 650                 655     
Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu Ala
            660                 665                 670         
His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu Gln
        675                 680                 685             
Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg Leu
    690                 695                 700                 
Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala Ser
705                 710                 715                 720 
Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu Glu
                725                 730                 735     
Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu Gln
            740                 745                 750         
Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu Arg
        755                 760                 765             
Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg Glu
    770                 775                 780                 
Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala Gln
785                 790                 795                 800 
Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala Leu
                805                 810                 815     
Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln Glu
            820                 825                 830         
Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu Leu
        835                 840                 845             
Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu Lys
    850                 855                 860                 
Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met Leu
865                 870                 875                 880 
Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg Gln
                885                 890                 895     
Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr Gln
            900                 905                 910         
Gln Ser Met Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His Lys
        915                 920                 925             
Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala Ser
    930                 935                 940                 
Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His Asp
945                 950                 955                 960 
Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn Ile
                965                 970                 975     
His Lys Ala Thr Cys Glu Thr Ala Asp Arg Glu Arg Ala Glu Met Ser
            980                 985                 990         
Thr Glu Ile Ser Arg Leu Gln Ser Lys Ile Lys Glu Met Gln Gln Ala
        995                 1000                1005            
Thr Ser Pro Leu Ser Met Leu Gln Asn Gly Cys Gln Val Ile Gly Glu
    1010                1015                1020                
Glu Glu Val Glu Gly Asp Gly Ala Leu Ser Leu Leu Gln Gln Gly Glu
1025                1030                1035                1040
Gln Leu Leu Glu Glu Asn Gly Asp Val Leu Leu Ser Leu Gln Arg Ala
                1045                1050                1055    
His Glu Gln Ala Val Lys Glu Asn Val Lys Met Ala Thr Glu Ile Ser
            1060                1065                1070        
Arg Leu Gln Gln Arg Leu Gln Lys Leu Glu Pro Gly Leu Val Met Ser
        1075                1080                1085            
Ser Cys Leu Asp Glu Pro Ala Thr Glu Phe Phe Gly Asn Thr Ala Glu
    1090                1095                1100                
Gln Thr Glu Pro Phe Leu Gln Gln Asn Arg Thr Lys Gln Val Glu Gly
1105                1110                1115                1120
Val Thr Arg Arg His Val Leu Ser Asp Leu Glu Asp Asp Glu Val Arg
                1125                1130                1135    
Asp Leu Gly Ser Thr Gly Thr Ser Ser Val Gln Arg Gln Glu Ala Lys
            1140                1145                1150        
Ile Glu Glu Ser Glu Ala Ser Val Glu Gly Phe Ser Glu Leu Glu Asn
        1155                1160                1165            
Ser Glu Glu Thr Arg Thr Glu Ser Trp Glu Leu Lys Asn Gln Ile Ser
    1170                1175                1180                
Gln Leu Gln Glu Gln Leu Met Met Leu Cys Ala Asp Cys Asp Arg Ala
1185                1190                1195                1200
Ser Glu Lys Lys Gln Asp Leu Leu Phe Asp Val Ser Val Leu Lys Lys
                1205                1210                1215    
Lys Leu Lys Met Leu Glu Arg Ile Pro Glu Ala Ser Pro Lys Tyr Lys
            1220                1225                1230        
Leu Leu Tyr Glu Asp Val Ser Arg Glu Asn Asp Cys Leu Gln Glu Glu
        1235                1240                1245            
Leu Arg Met Met Glu Thr Arg Tyr Asp Glu Ala Leu Glu Asn Asn Lys
    1250                1255                1260                
Glu Leu Thr Ala Glu Val Phe Arg Leu Gln Asp Glu Leu Lys Lys Met
1265                1270                1275                1280
Glu Glu Val Thr Glu Thr Phe Leu Ser Leu Glu Lys Ser Tyr Asp Glu
                1285                1290                1295    
Val Lys Ile Glu Asn Glu Glu Leu Asn Val Leu Val Leu Arg Leu Gln
            1300                1305                1310        
Gly Lys Ile Glu Lys Leu Gln Glu Ser Val Val Gln Arg Cys Asp Cys
        1315                1320                1325            
Cys Leu Trp Glu Ala Ser Leu Glu Asn Leu Glu Ile Glu Pro Asp Gly
    1330                1335                1340                
Asn Ile Leu Gln Leu Asn Gln Thr Leu Glu Glu Cys Val Pro Arg Val
1345                1350                1355                1360
Arg Ser Val His His Val Ile Glu Glu Cys Lys Gln Glu Asn Gln Tyr
                1365                1370                1375    
Leu Glu Gly Asn Thr Gln Leu Leu Glu Lys Val Lys Ala His Glu Ile
            1380                1385                1390        
Ala Trp Leu His Gly Thr Ile Gln Thr His Gln Glu Arg Pro Arg Val
        1395                1400                1405            
Gln Asn Gln Val Ile Leu Glu Glu Asn Thr Thr Leu Leu Gly Phe Gln
    1410                1415                1420                
Asp Lys His Phe Gln His Gln Ala Thr Ile Ala Glu Leu Glu Leu Glu
1425                1430                1435                1440
Lys Thr Lys Leu Gln Glu Leu Thr Arg Lys Leu Lys Glu Arg Val Thr
                1445                1450                1455    
Ile Leu Val Lys Gln Lys Asp Val Leu Ser His Gly Glu Lys Glu Glu
            1460                1465                1470        
Glu Leu Lys Ala Met Met His Asp Leu Gln Ile Thr Cys Ser Glu Met
        1475                1480                1485            
Gln Gln Lys Val Glu Leu Leu Arg Tyr Glu Ser Glu Lys Leu Gln Gln
    1490                1495                1500                
Glu Asn Ser Ile Leu Arg Asn Glu Ile Thr Thr Leu Asn Glu Glu Asp
1505                1510                1515                1520
Ser Ile Ser Asn Leu Lys Leu Gly Thr Leu Tyr Trp Asn Ser Gly Arg
                1525                1530                1535    
Met Arg Gln Lys Thr Glu Thr Val Lys Gln Glu Asn Ala Ala Val Gln
            1540                1545                1550        
Lys Met Val Glu Asn Leu Lys Lys Gln Ile Ser Glu Leu Lys Ile Lys
        1555                1560                1565            
Asn Gln Gln Leu Asp Leu Glu Asn Thr Glu Leu Ser Gln Lys Asn Ser
    1570                1575                1580                
Gln Asn Gln Glu Lys Leu Gln Glu Leu Asn Gln Arg Leu Thr Glu Met
1585                1590                1595                1600
Leu Cys Gln Lys Glu Lys Glu Pro Gly Asn Ser Ala Leu Glu Glu Arg
                1605                1610                1615    
Glu Gln Glu Lys Phe Asn Leu Lys Glu Glu Leu Glu Arg Cys Lys Val
            1620                1625                1630        
Gln Ser Ser Thr Leu Val Ser Ser Leu Glu Ala Glu Leu Ser Glu Val
        1635                1640                1645            
Lys Ile Gln Thr His Ile Val Gln Gln Glu Asn His Leu Leu Lys Asp
    1650                1655                1660                
Glu Leu Glu Lys Met Lys Gln Leu His Arg Cys Pro Asp Leu Ser Asp
1665                1670                1675                1680
Phe Gln Gln Lys Ile Ser Ser Val Leu Ser Tyr Asn Glu Lys Leu Leu
                1685                1690                1695    
Lys Glu Lys Glu Ala Leu Ser Glu Glu Leu Asn Ser Cys Val Asp Lys
            1700                1705                1710        
Leu Ala Lys Ser Ser Leu Leu Glu His Arg Ile Ala Thr Met Lys Gln
        1715                1720                1725            
Glu Gln Lys Ser Trp Glu His Gln Ser Ala Ser Leu Lys Ser Gln Leu
    1730                1735                1740                
Val Ala Ser Gln Glu Lys Val Gln Asn Leu Glu Asp Thr Val Gln Asn
1745                1750                1755                1760
Val Asn Leu Gln Met Ser Arg Met Lys Ser Asp Leu Arg Val Thr Gln
                1765                1770                1775    
Gln Glu Lys Glu Ala Leu Lys Gln Glu Val Met Ser Leu His Lys Gln
            1780                1785                1790        
Leu Gln Asn Ala Gly Gly Lys Ser Trp Ala Pro Glu Ile Ala Thr His
        1795                1800                1805            
Pro Ser Gly Leu His Asn Gln Gln Lys Arg Leu Ser Trp Asp Lys Leu
    1810                1815                1820                
Asp His Leu Met Asn Glu Glu Gln Gln Leu Leu Trp Gln Glu Asn Glu
1825                1830                1835                1840
Arg Ser Gln Thr Met Val Gln Glu His Gln Ser Arg Leu Thr His Ser
                1845                1850                1855    
Arg Glu Lys Val Arg Gln Leu Glu Ser Asn Leu Leu Pro Lys His Gln
            1860                1865                1870        
Lys His Leu Asn Pro Ser Gly Thr Met Asn Pro Thr Glu Gln Glu Lys
        1875                1880                1885            
Leu Ser Leu Lys Arg Glu Cys Asp Gln Phe Gln Lys Glu Gln Ser Pro
    1890                1895                1900                
Ala Asn Arg Lys Val Ser Gln Met Asn Ser Leu Glu Gln Glu Leu Glu
1905                1910                1915                1920
Thr Ile His Leu Glu Asn Glu Gly Leu Lys Lys Lys Gln Val Lys Leu
                1925                1930                1935    
Asp Glu Gln Leu Met Glu Met Gln His Leu Arg Ser Thr Ala Thr Pro
            1940                1945                1950        
Ser Pro Ser Pro His Ala Trp Asp Leu Gln Leu Leu Gln Gln Gln Ala
        1955                1960                1965            
Cys Pro Met Val Pro Arg Glu Gln Phe Leu Gln Leu Gln Arg Gln Leu
    1970                1975                1980                
Leu Gln Ala Glu Arg Ile Asn Gln His Leu Gln Glu Glu Leu Glu Asn
1985                1990                1995                2000
Arg Thr Ser Glu Thr Asn Thr Pro Gln Gly Asn Gln Glu Gln Leu Val
                2005                2010                2015    
Thr Val Met Glu Glu Arg Met Ile Glu Val Glu Gln Lys Leu Lys Leu
            2020                2025                2030        
Val Lys Arg Leu Leu Gln Glu Lys Val Asn Gln Leu Lys Glu Gln Val
        2035                2040                2045            
Ser Leu Pro Gly His Leu Cys Ser Pro Thr Ser His Ser Ser Phe Asn
    2050                2055                2060                
Ser Ser Phe Thr Ser Leu Tyr Cys His
2065                2070            


<210> 8482
<211> 2029
<212> PRT
<213> Homo sapiens

<400> 8482
Met Asp Glu Leu Asp Gln Asp Gln His Gly Arg Leu Lys Asp Leu Phe
 1               5                  10                  15      
Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu Leu
            20                  25                  30          
Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val Leu
        35                  40                  45              
Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe Asp
    50                  55                  60                  
Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser Asn
65                  70                  75                  80  
Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro Lys
                85                  90                  95      
Tyr Val Arg Gly Gly Lys Arg Tyr Gly Arg Arg Ser Leu Pro Glu Phe
            100                 105                 110         
Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro Leu
        115                 120                 125             
Asp Glu Glu Ala Arg Ala Ser His Ile Pro Ala Gly Asp Cys Ser Glu
    130                 135                 140                 
His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln Leu
145                 150                 155                 160 
Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser Ser
                165                 170                 175     
Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Glu Val Cys Glu Asp
            180                 185                 190         
Leu Gly Ile Thr Arg Asp Gly His Leu Asn Arg Lys Lys Leu Val Ser
        195                 200                 205             
Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu Glu
    210                 215                 220                 
Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu Asp
225                 230                 235                 240 
Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser Ala
                245                 250                 255     
Ser Thr Pro Tyr Arg Gln Thr Lys Lys Ala Pro Phe Ser Met Gln Ser
            260                 265                 270         
Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Met Thr Ser
        275                 280                 285             
Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His
    290                 295                 300                 
Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu
305                 310                 315                 320 
Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn
                325                 330                 335     
Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Tyr Glu Leu Leu Val
            340                 345                 350         
Thr Lys Asn Ser Thr His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu
        355                 360                 365             
Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Glu
    370                 375                 380                 
Lys Leu Arg Ser Asp Leu Asp Lys Ala Glu Lys Leu Lys Ser Leu Met
385                 390                 395                 400 
Ala Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu
                405                 410                 415     
Tyr Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala
            420                 425                 430         
Leu Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala
        435                 440                 445             
Gly Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr
    450                 455                 460                 
Glu Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn
465                 470                 475                 480 
Ser Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Asn Val Leu Ala
                485                 490                 495     
Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu Gln
            500                 505                 510         
Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys Arg
        515                 520                 525             
Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu Tyr
    530                 535                 540                 
Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro Ser
545                 550                 555                 560 
Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly Leu
                565                 570                 575     
Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu Leu
            580                 585                 590         
Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys Leu
        595                 600                 605             
Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu Asp
    610                 615                 620                 
Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln Arg
625                 630                 635                 640 
His Glu Asn Glu Thr His Thr Leu Glu Lys Gln Ile Ser Asp Leu Lys
                645                 650                 655     
Asn Glu Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu Ala
            660                 665                 670         
His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu Gln
        675                 680                 685             
Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg Leu
    690                 695                 700                 
Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala Ser
705                 710                 715                 720 
Phe Glu Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu Glu
                725                 730                 735     
Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu Gln
            740                 745                 750         
Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu Arg
        755                 760                 765             
Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg Glu
    770                 775                 780                 
Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala Gln
785                 790                 795                 800 
Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala Leu
                805                 810                 815     
Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln Glu
            820                 825                 830         
Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu Leu
        835                 840                 845             
Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu Lys
    850                 855                 860                 
Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met Leu
865                 870                 875                 880 
Glu Lys Thr Tyr Lys Glu His Leu Asn Ser Met Val Val Glu Arg Gln
                885                 890                 895     
Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr Gln
            900                 905                 910         
Gln Ser Met Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His Lys
        915                 920                 925             
Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Ala Gly Ala Ser
    930                 935                 940                 
Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His Asp
945                 950                 955                 960 
Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn Ile
                965                 970                 975     
His Lys Ala Thr Cys Glu Thr Ala Asp Arg Glu Arg Ala Glu Met Ser
            980                 985                 990         
Thr Glu Ile Ser Arg Leu Gln Ser Lys Ile Lys Glu Met Gln Gln Ala
        995                 1000                1005            
Thr Ser Pro Leu Ser Met Leu Gln Asn Gly Cys Gln Val Ile Gly Glu
    1010                1015                1020                
Glu Glu Val Glu Gly Asp Gly Ala Leu Ser Leu Leu Gln Gln Gly Glu
1025                1030                1035                1040
Gln Leu Leu Glu Glu Asn Gly Asp Val Leu Leu Ser Leu Gln Arg Ala
                1045                1050                1055    
His Glu Gln Ala Val Lys Glu Asn Val Lys Met Ala Thr Glu Ile Ser
            1060                1065                1070        
Arg Leu Gln Gln Arg Leu Gln Lys Leu Glu Pro Gly Leu Val Met Ser
        1075                1080                1085            
Ser Cys Leu Asp Glu Pro Ala Thr Glu Phe Phe Gly Asn Thr Ala Glu
    1090                1095                1100                
Gln Thr Glu Pro Phe Leu Gln Gln Asn Arg Thr Lys Gln Val Glu Gly
1105                1110                1115                1120
Val Thr Arg Arg His Val Leu Ser Asp Leu Glu Asp Asp Glu Val Arg
                1125                1130                1135    
Asp Leu Gly Ser Thr Gly Thr Ser Ser Val Gln Arg Gln Glu Ala Lys
            1140                1145                1150        
Ile Glu Glu Ser Glu Ala Ser Val Glu Gly Phe Ser Glu Leu Glu Asn
        1155                1160                1165            
Ser Glu Glu Thr Arg Thr Glu Ser Trp Glu Leu Lys Asn Gln Ile Ser
    1170                1175                1180                
Gln Leu Gln Glu Gln Leu Met Met Leu Cys Ala Asp Cys Asp Arg Ala
1185                1190                1195                1200
Ser Glu Lys Lys Gln Asp Leu Leu Phe Asp Val Ser Val Leu Lys Lys
                1205                1210                1215    
Lys Leu Lys Met Leu Glu Arg Ile Pro Glu Ala Ser Pro Lys Tyr Lys
            1220                1225                1230        
Leu Leu Tyr Glu Asp Val Ser Arg Glu Asn Asp Cys Leu Gln Glu Glu
        1235                1240                1245            
Leu Arg Met Met Glu Thr Arg Tyr Asp Glu Ala Leu Glu Asn Asn Lys
    1250                1255                1260                
Glu Leu Thr Ala Glu Val Phe Arg Leu Gln Asp Glu Leu Lys Lys Met
1265                1270                1275                1280
Glu Glu Val Thr Glu Thr Phe Leu Ser Leu Glu Lys Ser Tyr Asp Glu
                1285                1290                1295    
Val Lys Ile Glu Asn Glu Glu Leu Asn Val Leu Val Leu Arg Leu Gln
            1300                1305                1310        
Gly Lys Ile Glu Lys Leu Gln Glu Ser Val Val Gln Arg Cys Asp Cys
        1315                1320                1325            
Cys Leu Trp Glu Ala Ser Leu Glu Asn Leu Glu Ile Glu Pro Asp Gly
    1330                1335                1340                
Asn Ile Leu Gln Leu Asn Gln Thr Leu Glu Glu Cys Val Pro Arg Val
1345                1350                1355                1360
Arg Ser Val His His Val Ile Glu Glu Cys Lys Gln Glu Asn Gln Tyr
                1365                1370                1375    
Leu Glu Gly Asn Thr Gln Leu Leu Glu Lys Val Lys Ala His Glu Ile
            1380                1385                1390        
Ala Trp Leu His Gly Thr Ile Gln Thr His Gln Glu Arg Pro Arg Val
        1395                1400                1405            
Gln Asn Gln Val Ile Leu Glu Glu Asn Thr Thr Leu Leu Gly Phe Gln
    1410                1415                1420                
Asp Lys His Phe Gln His Gln Ala Thr Ile Ala Glu Leu Glu Leu Glu
1425                1430                1435                1440
Lys Thr Lys Leu Gln Glu Leu Thr Arg Lys Leu Lys Glu Arg Val Thr
                1445                1450                1455    
Ile Leu Val Lys Gln Lys Asp Val Leu Ser His Gly Glu Lys Glu Glu
            1460                1465                1470        
Glu Leu Lys Ala Met Met His Asp Leu Gln Ile Thr Cys Ser Glu Met
        1475                1480                1485            
Gln Gln Lys Val Glu Leu Leu Arg Tyr Glu Ser Glu Lys Leu Gln Gln
    1490                1495                1500                
Glu Asn Ser Ile Leu Arg Asn Glu Ile Thr Thr Leu Asn Glu Glu Asp
1505                1510                1515                1520
Ser Ile Ser Asn Leu Lys Leu Gly Thr Leu Tyr Trp Asn Ser Gly Arg
                1525                1530                1535    
Met Arg Gln Lys Thr Glu Thr Val Lys Gln Glu Asn Ala Ala Val Gln
            1540                1545                1550        
Lys Met Val Glu Asn Leu Lys Lys Gln Ile Ser Glu Leu Lys Ile Lys
        1555                1560                1565            
Asn Gln Gln Leu Asp Leu Glu Asn Thr Glu Leu Ser Gln Lys Asn Ser
    1570                1575                1580                
Gln Asn Gln Glu Lys Leu Gln Glu Leu Asn Gln Arg Leu Thr Glu Met
1585                1590                1595                1600
Leu Cys Gln Lys Glu Lys Glu Pro Gly Asn Ser Ala Leu Glu Glu Arg
                1605                1610                1615    
Glu Gln Glu Lys Phe Asn Leu Lys Glu Glu Leu Glu Arg Cys Lys Val
            1620                1625                1630        
Gln Ser Ser Thr Leu Val Ser Ser Leu Glu Ala Glu Leu Ser Glu Val
        1635                1640                1645            
Lys Ile Gln Thr His Ile Val Gln Gln Glu Asn His Leu Leu Lys Asp
    1650                1655                1660                
Glu Leu Glu Lys Met Lys Gln Leu His Arg Cys Pro Asp Leu Ser Asp
1665                1670                1675                1680
Phe Gln Gln Lys Ile Ser Ser Val Leu Ser Tyr Asn Glu Lys Leu Leu
                1685                1690                1695    
Lys Glu Lys Glu Ala Leu Ser Glu Glu Leu Asn Ser Cys Val Asp Lys
            1700                1705                1710        
Leu Ala Lys Ser Ser Leu Leu Glu His Arg Ile Ala Thr Met Lys Gln
        1715                1720                1725            
Glu Gln Lys Ser Trp Glu His Gln Ser Ala Ser Leu Lys Ser Gln Leu
    1730                1735                1740                
Val Ala Ser Gln Glu Lys Val Gln Asn Leu Glu Asp Thr Val Gln Asn
1745                1750                1755                1760
Val Asn Leu Gln Met Ser Arg Met Lys Ser Asp Leu Arg Val Thr Gln
                1765                1770                1775    
Gln Glu Lys Glu Ala Leu Lys Gln Glu Val Met Ser Leu His Lys Gln
            1780                1785                1790        
Leu Gln Asn Ala Gly Gly Lys Ser Trp Ala Pro Glu Ile Ala Thr His
        1795                1800                1805            
Pro Ser Gly Leu His Asn Gln Gln Lys Arg Leu Ser Trp Asp Lys Leu
    1810                1815                1820                
Asp His Leu Met Asn Glu Glu Gln Gln Leu Leu Trp Gln Glu Asn Glu
1825                1830                1835                1840
Arg Ser Gln Thr Met Val Gln Asn Thr Lys Ala Glu Leu Thr His Ser
                1845                1850                1855    
Arg Glu Lys Val Arg Gln Leu Glu Ser Asn Leu Leu Pro Lys His Gln
            1860                1865                1870        
Lys His Leu Asn Pro Ser Gly Thr Met Asn Pro Thr Glu Gln Glu Lys
        1875                1880                1885            
Leu Ser Leu Lys Arg Glu Cys Asp Gln Phe Gln Lys Glu Gln Ser Pro
    1890                1895                1900                
Ala Asn Arg Lys Val Ser Gln Met Asn Ser Leu Glu Gln Glu Leu Glu
1905                1910                1915                1920
Thr Ile His Leu Glu Asn Glu Gly Leu Lys Lys Lys Gln Val Lys Leu
                1925                1930                1935    
Asp Glu Gln Leu Met Glu Met Gln His Leu Arg Ser Thr Ala Thr Pro
            1940                1945                1950        
Ser Pro Ser Pro His Ala Trp Asp Leu Gln Leu Leu Gln Gln Gln Ala
        1955                1960                1965            
Cys Pro Met Val Pro Arg Glu Gln Phe Leu Gln Leu Gln Arg Gln Leu
    1970                1975                1980                
Leu Gln Ala Glu Arg Ile Asn Gln His Leu Gln Glu Glu Leu Glu Asn
1985                1990                1995                2000
Arg Thr Ser Glu Thr Asn Thr Pro Gln Ala Leu Leu Pro Glu Gln Arg
                2005                2010                2015    
Ala Val His Ala Asp Ser Tyr Arg Arg Ile Gly His Leu
            2020                2025                


<210> 8483
<211> 1322
<212> PRT
<213> Homo sapiens

<400> 8483
Met Pro Val Val Trp Pro Thr Leu Leu Asp Leu Ser Arg Asp Glu Cys
 1               5                  10                  15      
Lys Arg Ile Leu Arg Lys Leu Glu Leu Glu Ala Tyr Ala Gly Val Ile
            20                  25                  30          
Ser Ala Leu Arg Ala Gln Gly Asp Leu Thr Lys Glu Lys Lys Asp Leu
        35                  40                  45              
Leu Gly Glu Leu Ser Lys Val Leu Ser Ile Ser Thr Glu Arg His Arg
    50                  55                  60                  
Ala Glu Val Arg Arg Ala Val Asn Asp Glu Arg Leu Thr Thr Ile Ala
65                  70                  75                  80  
His Asn Met Ser Gly Pro Asn Ser Ser Ser Glu Trp Ser Ile Glu Gly
                85                  90                  95      
Arg Arg Leu Val Pro Leu Met Pro Arg Leu Val Pro Gln Thr Ala Phe
            100                 105                 110         
Thr Val Thr Ala Asn Ala Val Ala Asn Ala Ala Ile Gln His Asn Ala
        115                 120                 125             
Ser Leu Pro Val Pro Ala Glu Thr Gly Ser Lys Glu Val Val Cys Tyr
    130                 135                 140                 
Ser Tyr Thr Ser Thr Thr Ser Thr Pro Thr Ser Thr Pro Val Pro Ser
145                 150                 155                 160 
Gly Ser Ile Ala Thr Val Lys Ser Pro Arg Pro Ala Ser Pro Ala Ser
                165                 170                 175     
Asn Val Val Val Leu Pro Ser Gly Ser Thr Val Tyr Val Lys Ser Val
            180                 185                 190         
Ser Cys Ser Asp Glu Asp Glu Lys Pro Arg Lys Arg Arg Arg Thr Asn
        195                 200                 205             
Ser Ser Ser Ser Ser Pro Val Val Leu Lys Glu Val Pro Lys Ala Val
    210                 215                 220                 
Val Pro Val Ser Lys Thr Ile Thr Val Pro Val Ser Gly Ser Pro Lys
225                 230                 235                 240 
Met Ser Asn Ile Met Gln Ser Ile Ala Asn Ser Leu Pro Pro His Met
                245                 250                 255     
Ser Pro Val Lys Ile Thr Phe Thr Lys Pro Ser Thr Gln Thr Thr Asn
            260                 265                 270         
Thr Thr Thr Gln Lys Val Ile Ile Val Thr Thr Ser Pro Ser Ser Thr
        275                 280                 285             
Phe Val Pro Asn Ile Leu Ser Lys Ser His Asn Tyr Ala Ala Val Thr
    290                 295                 300                 
Lys Leu Val Pro Thr Ser Val Ile Ala Ser Thr Thr Gln Lys Pro Pro
305                 310                 315                 320 
Val Val Ile Thr Ala Ser Gln Ser Ser Leu Val Ser Asn Ser Ser Ser
                325                 330                 335     
Gly Ser Ser Ser Ser Thr Pro Ser Pro Ile Pro Asn Thr Val Ala Val
            340                 345                 350         
Thr Ala Val Val Ser Ser Thr Pro Ser Val Val Met Ser Thr Val Ala
        355                 360                 365             
Gln Gly Val Ser Thr Ser Ala Ile Lys Met Ala Ser Thr Arg Leu Pro
    370                 375                 380                 
Ser Pro Lys Ser Leu Val Ser Ala Pro Thr Gln Ile Leu Ala Gln Phe
385                 390                 395                 400 
Pro Lys Gln His Gln Gln Ser Pro Lys Gln Gln Leu Tyr Gln Val Gln
                405                 410                 415     
Gln Gln Thr Gln Gln Gln Val Ala Gln Pro Ser Pro Val Ser His Gln
            420                 425                 430         
Gln Gln Pro Gln Gln Ser Pro Leu Pro Pro Gly Ile Lys Pro Thr Ile
        435                 440                 445             
Gln Ile Lys Gln Glu Ser Gly Val Lys Ile Ile Thr Gln Gln Val Gln
    450                 455                 460                 
Pro Ser Lys Ile Leu Pro Lys Pro Val Thr Ala Thr Leu Pro Thr Ser
465                 470                 475                 480 
Ser Asn Ser Pro Ile Met Val Val Ser Ser Asn Gly Ala Ile Met Thr
                485                 490                 495     
Thr Lys Leu Val Thr Thr Pro Thr Gly Thr Gln Ala Thr Tyr Thr Arg
            500                 505                 510         
Pro Thr Val Ser Pro Ser Ile Gly Arg Met Ala Ala Thr Pro Gly Ala
        515                 520                 525             
Ala Thr Tyr Val Lys Thr Thr Ser Gly Ser Ile Ile Thr Val Val Pro
    530                 535                 540                 
Lys Ser Leu Ala Thr Leu Gly Gly Lys Ile Ile Ser Ser Asn Ile Val
545                 550                 555                 560 
Ser Gly Thr Thr Thr Lys Ile Thr Thr Ile Pro Met Thr Ser Lys Pro
                565                 570                 575     
Asn Val Ile Val Val Gln Lys Thr Thr Gly Lys Gly Thr Thr Ile Gln
            580                 585                 590         
Gly Leu Pro Gly Lys Asn Val Val Thr Thr Leu Leu Asn Ala Gly Gly
        595                 600                 605             
Glu Lys Thr Ile Gln Thr Val Pro Thr Gly Ala Lys Pro Ala Ile Leu
    610                 615                 620                 
Thr Ala Thr Arg Pro Ile Thr Lys Met Ile Val Thr Gln Pro Lys Gly
625                 630                 635                 640 
Ile Gly Ser Thr Val Gln Pro Ala Ala Lys Ile Ile Pro Thr Lys Ile
                645                 650                 655     
Val Tyr Gly Gln Gln Gly Lys Thr Gln Val Leu Ile Lys Pro Lys Pro
            660                 665                 670         
Val Thr Phe Gln Ala Thr Val Val Ser Glu Gln Thr Arg Gln Leu Val
        675                 680                 685             
Thr Glu Thr Leu Gln Gln Ala Ser Arg Val Ala Glu Ala Gly Asn Ser
    690                 695                 700                 
Ser Ile Gln Glu Gly Lys Glu Glu Pro Gln Asn Tyr Thr Asp Ser Ser
705                 710                 715                 720 
Ser Ser Ser Thr Glu Ser Ser Gln Ser Ser Gln Asp Ser Gln Pro Val
                725                 730                 735     
Val His Val Ile Ala Ser Arg Arg Gln Asp Trp Ser Glu His Glu Ile
            740                 745                 750         
Ala Met Glu Thr Ser Pro Thr Ile Ile Tyr Gln Asp Val Ser Ser Glu
        755                 760                 765             
Ser Gln Ser Ala Thr Ser Thr Ile Lys Ala Leu Leu Glu Leu Gln Gln
    770                 775                 780                 
Thr Thr Val Lys Glu Lys Leu Glu Ser Lys Pro Arg Gln Pro Thr Ile
785                 790                 795                 800 
Asp Leu Ser Gln Met Ala Val Pro Ile Gln Met Thr Gln Glu Lys Arg
                805                 810                 815     
His Ser Pro Glu Ser Pro Ser Ile Ala Val Val Glu Ser Glu Leu Val
            820                 825                 830         
Ala Glu Tyr Ile Thr Thr Glu Arg Thr Asp Glu Gly Thr Glu Val Ala
        835                 840                 845             
Phe Pro Leu Leu Val Ser His Arg Ser Gln Pro Gln Gln Pro Ser Gln
    850                 855                 860                 
Pro Gln Arg Thr Leu Leu Gln His Val Ala Gln Ser Gln Thr Ala Thr
865                 870                 875                 880 
Gln Thr Ser Val Val Val Lys Ser Ile Pro Ala Ser Ser Pro Gly Ala
                885                 890                 895     
Ile Thr His Ile Met Gln Gln Ala Leu Ser Ser His Thr Ala Phe Thr
            900                 905                 910         
Lys His Ser Glu Glu Leu Gly Thr Glu Glu Gly Glu Val Glu Glu Met
        915                 920                 925             
Asp Thr Leu Asp Pro Gln Thr Gly Leu Phe Tyr Arg Ser Ala Leu Thr
    930                 935                 940                 
Gln Ser Gln Ser Ala Lys Gln Gln Lys Leu Ser Gln Pro Pro Leu Glu
945                 950                 955                 960 
Gln Thr Gln Leu Gln Val Lys Thr Leu Gln Cys Phe Gln Thr Lys Gln
                965                 970                 975     
Lys Gln Thr Ile His Leu Gln Ala Asp Gln Leu Gln His Lys Leu Pro
            980                 985                 990         
Gln Met Pro Gln Leu Ser Ile Arg His Gln Lys Leu Thr Pro Leu Gln
        995                 1000                1005            
Gln Glu Gln Ala Gln Pro Lys Pro Asp Val Gln His Thr Gln His Pro
    1010                1015                1020                
Met Val Ala Lys Asp Arg Gln Leu Pro Thr Leu Met Ala Gln Pro Pro
1025                1030                1035                1040
Gln Thr Val Val Gln Val Leu Ala Val Lys Thr Thr Gln Gln Leu Pro
                1045                1050                1055    
Lys Leu Gln Gln Ala Pro Asn Gln Pro Lys Ile Tyr Val Gln Pro Gln
            1060                1065                1070        
Thr Pro Gln Ser Gln Met Ser Leu Pro Ala Ser Ser Glu Lys Gln Thr
        1075                1080                1085            
Ala Ser Gln Val Glu Gln Pro Ile Ile Thr Gln Gly Ser Ser Val Thr
    1090                1095                1100                
Lys Ile Thr Phe Glu Gly Arg Gln Pro Pro Thr Val Thr Lys Ile Thr
1105                1110                1115                1120
Gly Gly Ser Ser Val Pro Lys Leu Thr Ser Pro Val Thr Ser Ile Ser
                1125                1130                1135    
Pro Ile Gln Ala Ser Glu Lys Thr Ala Val Ser Asp Ile Leu Lys Met
            1140                1145                1150        
Ser Leu Met Glu Ala Gln Ile Asp Thr Asn Val Glu His Met Ile Val
        1155                1160                1165            
Asp Pro Pro Lys Lys Ala Leu Ala Thr Ser Met Leu Thr Gly Glu Ala
    1170                1175                1180                
Gly Ser Leu Pro Ser Thr His Met Val Val Ala Gly Met Ala Asn Ser
1185                1190                1195                1200
Thr Pro Gln Gln Gln Lys Cys Arg Glu Ser Cys Ser Ser Pro Ser Thr
                1205                1210                1215    
Val Gly Ser Ser Leu Thr Thr Arg Lys Ile Asp Pro Pro Ala Val Pro
            1220                1225                1230        
Ala Thr Gly Gln Phe Met Arg Ile Gln Asn Val Gly Gln Lys Lys Ala
        1235                1240                1245            
Glu Glu Ser Pro Ala Glu Ile Ile Ile Gln Ala Ile Pro Gln Tyr Ala
    1250                1255                1260                
Ile Pro Cys His Ser Ser Ser Asn Val Val Val Glu Pro Ser Gly Leu
1265                1270                1275                1280
Leu Glu Leu Asn Asn Phe Thr Ser Gln Gln Leu Asp Asp Glu Glu Thr
                1285                1290                1295    
Ala Met Glu Gln Asp Ile Asp Ser Ser Thr Glu Asp Gly Thr Glu Pro
            1300                1305                1310        
Ser Pro Ser Gln Ser Ser Ala Glu Arg Ser
        1315                1320        


<210> 8484
<211> 786
<212> PRT
<213> Homo sapiens

<400> 8484
Met Lys Gly Thr Gly Ile Met Asp Cys Ala Pro Lys Ala Leu Leu Ala
 1               5                  10                  15      
Arg Ala Leu Tyr Asp Asn Cys Pro Asp Cys Ser Asp Glu Leu Ala Phe
            20                  25                  30          
Ser Arg Gly Asp Ile Leu Thr Ile Leu Glu Gln His Val Pro Glu Ser
        35                  40                  45              
Glu Gly Trp Trp Lys Cys Leu Leu His Gly Arg Gln Gly Leu Ala Pro
    50                  55                  60                  
Ala Asn Arg Leu Gln Ile Leu Thr Glu Val Ala Ala Asp Arg Pro Cys
65                  70                  75                  80  
Pro Pro Phe Leu Arg Gly Leu Glu Glu Ala Pro Ala Ser Ser Glu Glu
                85                  90                  95      
Thr Tyr Gln Val Pro Thr Leu Pro Arg Pro Pro Thr Pro Gly Pro Val
            100                 105                 110         
Tyr Glu Gln Met Arg Ser Trp Ala Glu Gly Pro Gln Pro Pro Thr Ala
        115                 120                 125             
Gln Val Tyr Glu Phe Pro Asp Pro Pro Thr Ser Ala Arg Ile Ile Cys
    130                 135                 140                 
Glu Lys Thr Leu Ser Phe Pro Lys Gln Ala Ile Leu Thr Leu Pro Arg
145                 150                 155                 160 
Pro Val Arg Ala Ser Leu Pro Thr Leu Pro Ser Gln Val Tyr Asp Val
                165                 170                 175     
Pro Thr Gln His Arg Gly Pro Val Val Leu Lys Glu Pro Glu Lys Gln
            180                 185                 190         
Gln Leu Tyr Asp Ile Pro Ala Ser Pro Lys Lys Ala Gly Leu His Pro
        195                 200                 205             
Pro Asp Ser Gln Ala Ser Gly Gln Gly Val Pro Leu Ile Ser Val Thr
    210                 215                 220                 
Thr Leu Arg Arg Gly Gly Tyr Ser Thr Leu Pro Asn Pro Gln Lys Ser
225                 230                 235                 240 
Glu Trp Ile Tyr Asp Thr Pro Val Ser Pro Gly Lys Ala Ser Val Arg
                245                 250                 255     
Asn Thr Pro Leu Thr Ser Phe Ala Glu Glu Ser Arg Pro His Ala Leu
            260                 265                 270         
Pro Ser Ser Ser Ser Thr Phe Tyr Asn Pro Pro Ser Gly Arg Ser Arg
        275                 280                 285             
Ser Leu Thr Pro Gln Leu Asn Asn Asn Val Pro Met Gln Lys Lys Leu
    290                 295                 300                 
Ser Leu Pro Glu Ile Pro Ser Tyr Gly Phe Leu Val Pro Arg Gly Thr
305                 310                 315                 320 
Phe Pro Leu Asp Glu Asp Val Ser Tyr Lys Val Pro Ser Ser Phe Leu
                325                 330                 335     
Ile Pro Arg Val Glu Gln Gln Asn Thr Lys Pro Asn Ile Tyr Asp Ile
            340                 345                 350         
Pro Lys Ala Thr Ser Ser Val Ser Gln Ala Gly Lys Glu Leu Glu Lys
        355                 360                 365             
Ala Lys Glu Val Ser Glu Asn Ser Ala Gly His Asn Ser Ser Trp Phe
    370                 375                 380                 
Ser Arg Arg Thr Thr Ser Pro Ser Pro Glu Pro Asp Arg Leu Ser Gly
385                 390                 395                 400 
Ser Ser Ser Asp Ser Arg Ala Ser Ile Val Ser Ser Cys Ser Thr Thr
                405                 410                 415     
Ser Thr Asp Asp Ser Ser Ser Ser Ser Ser Glu Glu Ser Ala Lys Glu
            420                 425                 430         
Leu Ser Leu Asp Leu Asp Val Ala Lys Glu Thr Val Met Ala Leu Gln
        435                 440                 445             
His Lys Val Val Ser Ser Val Ala Gly Leu Met Leu Phe Val Ser Arg
    450                 455                 460                 
Lys Trp Arg Phe Arg Asp Tyr Leu Glu Ala Asn Ile Asp Ala Ile His
465                 470                 475                 480 
Arg Ser Thr Asp His Ile Glu Glu Ser Val Arg Glu Phe Leu Asp Phe
                485                 490                 495     
Ala Arg Gly Val His Gly Thr Ala Cys Asn Leu Thr Asp Ser Asn Leu
            500                 505                 510         
Gln Asn Arg Ile Arg Asp Gln Met Gln Thr Ile Ser Asn Ser Tyr Arg
        515                 520                 525             
Ile Leu Leu Glu Thr Lys Glu Ser Leu Asp Asn Arg Asn Trp Pro Leu
    530                 535                 540                 
Glu Val Leu Val Thr Asp Ser Val Gln Asn Ser Pro Asp Asp Leu Glu
545                 550                 555                 560 
Arg Phe Val Met Val Ala Arg Met Leu Pro Glu Asp Ile Lys Arg Phe
                565                 570                 575     
Ala Ser Ile Val Ile Ala Asn Gly Arg Leu Leu Phe Lys Arg Asn Cys
            580                 585                 590         
Glu Lys Glu Glu Thr Val Gln Leu Thr Pro Asn Ala Glu Phe Lys Cys
        595                 600                 605             
Glu Lys Tyr Ile Gln Pro Pro Gln Arg Glu Thr Glu Ser His Gln Lys
    610                 615                 620                 
Ser Thr Pro Ser Thr Lys Gln Arg Glu Asp Glu His Ser Ser Glu Leu
625                 630                 635                 640 
Leu Lys Lys Asn Arg Ala Asn Ile Cys Gly Gln Asn Pro Gly Pro Leu
                645                 650                 655     
Ile Pro Gln Pro Ser Ser Gln Gln Thr Pro Glu Arg Lys Pro Arg Leu
            660                 665                 670         
Ser Glu His Cys Arg Leu Tyr Phe Gly Ala Leu Phe Lys Ala Ile Ser
        675                 680                 685             
Ala Phe His Gly Ser Leu Ser Ser Ser Gln Pro Ala Glu Ile Ile Thr
    690                 695                 700                 
Gln Ser Lys Leu Val Ile Met Val Gly Gln Lys Leu Val Asp Thr Leu
705                 710                 715                 720 
Cys Met Glu Thr Gln Glu Arg Asp Val Arg Asn Glu Ile Leu Arg Gly
                725                 730                 735     
Ser Ser His Leu Cys Ser Leu Leu Lys Asp Val Ala Leu Ala Thr Lys
            740                 745                 750         
Asn Ala Val Leu Thr Tyr Pro Ser Pro Ala Ala Leu Gly His Leu Gln
        755                 760                 765             
Ala Glu Ala Glu Lys Leu Glu Gln His Thr Arg Gln Phe Arg Gly Thr
    770                 775                 780                 
Leu Gly
785     


<210> 8485
<211> 672
<212> PRT
<213> Homo sapiens

<400> 8485
Met Lys Gly Thr Gly Ile Met Asp Cys Ala Pro Lys Ala Leu Leu Ala
 1               5                  10                  15      
Arg Ala Leu Tyr Asp Asn Cys Pro Asp Cys Ser Asp Glu Leu Ala Phe
            20                  25                  30          
Ser Arg Gly Asp Ile Leu Thr Ile Leu Glu Gln His Val Pro Glu Ser
        35                  40                  45              
Glu Gly Trp Trp Lys Cys Leu Leu His Gly Arg Gln Gly Leu Ala Pro
    50                  55                  60                  
Ala Asn Arg Leu Gln Ile Leu Thr Glu Val Ala Ala Asp Arg Pro Cys
65                  70                  75                  80  
Pro Pro Phe Leu Arg Gly Leu Glu Glu Ala Pro Ala Ser Ser Glu Glu
                85                  90                  95      
Thr Tyr Gln Val Pro Thr Leu Pro Arg Pro Pro Thr Pro Gly Pro Val
            100                 105                 110         
Tyr Glu Gln Met Arg Ser Trp Ala Glu Gly Pro Gln Pro Pro Thr Ala
        115                 120                 125             
Gln Val Tyr Glu Phe Pro Asp Pro Pro Thr Ser Ala Arg Ile Ile Cys
    130                 135                 140                 
Glu Lys Thr Leu Ser Phe Pro Lys Gln Ala Ile Leu Thr Leu Pro Arg
145                 150                 155                 160 
Pro Val Arg Ala Ser Leu Pro Thr Leu Pro Ser Gln Val Tyr Asp Val
                165                 170                 175     
Pro Thr Gln His Arg Gly Pro Val Val Leu Lys Glu Pro Glu Lys Gln
            180                 185                 190         
Gln Leu Tyr Asp Ile Pro Ala Ser Pro Lys Lys Ala Gly Leu His Pro
        195                 200                 205             
Pro Asp Ser Gln Ala Ser Gly Gln Gly Val Pro Leu Ile Ser Val Thr
    210                 215                 220                 
Thr Leu Arg Arg Gly Gly Tyr Ser Thr Leu Pro Asn Pro Gln Lys Ser
225                 230                 235                 240 
Glu Trp Ile Tyr Asp Thr Pro Val Ser Pro Gly Lys Ala Ser Val Arg
                245                 250                 255     
Asn Thr Pro Leu Thr Ser Phe Ala Glu Glu Ser Arg Pro His Ala Leu
            260                 265                 270         
Pro Ser Ser Ser Ser Thr Phe Tyr Asn Pro Pro Ser Gly Arg Ser Arg
        275                 280                 285             
Ser Leu Thr Pro Gln Leu Asn Asn Asn Val Pro Met Gln Lys Lys Leu
    290                 295                 300                 
Ser Leu Pro Glu Ile Pro Ser Tyr Gly Phe Leu Val Pro Arg Gly Thr
305                 310                 315                 320 
Phe Pro Leu Asp Glu Asp Val Ser Tyr Lys Val Pro Ser Ser Phe Leu
                325                 330                 335     
Ile Pro Arg Val Glu Gln Gln Asn Thr Lys Pro Asn Ile Tyr Asp Ile
            340                 345                 350         
Pro Lys Ala Thr Ser Ser Val Ser Gln Ala Gly Lys Glu Leu Glu Lys
        355                 360                 365             
Ala Lys Glu Val Ser Glu Asn Ser Ala Gly His Asn Ser Ser Trp Phe
    370                 375                 380                 
Ser Arg Arg Thr Thr Ser Pro Ser Pro Glu Pro Asp Arg Leu Ser Gly
385                 390                 395                 400 
Ser Ser Ser Asp Ser Arg Ala Ser Ile Val Ser Ser Cys Ser Thr Thr
                405                 410                 415     
Ser Thr Asp Asp Ser Ser Ser Ser Ser Ser Glu Glu Ser Ala Lys Glu
            420                 425                 430         
Leu Ser Leu Asp Leu Asp Val Ala Lys Glu Thr Val Met Ala Leu Gln
        435                 440                 445             
His Lys Val Val Ser Ser Val Ala Gly Leu Met Leu Phe Val Ser Arg
    450                 455                 460                 
Lys Trp Arg Phe Arg Asp Tyr Leu Glu Ala Asn Ile Asp Ala Ile His
465                 470                 475                 480 
Arg Ser Thr Asp His Ile Glu Glu Ser Val Arg Glu Phe Leu Asp Phe
                485                 490                 495     
Ala Arg Gly Val His Gly Thr Ala Cys Asn Leu Thr Asp Ser Asn Leu
            500                 505                 510         
Gln Asn Arg Ile Arg Asp Gln Met Gln Thr Ile Ser Asn Ser Tyr Arg
        515                 520                 525             
Ile Leu Leu Glu Thr Lys Glu Ser Leu Asp Asn Arg Asn Trp Pro Leu
    530                 535                 540                 
Glu Val Leu Val Thr Asp Ser Val Gln Asn Ser Pro Asp Asp Leu Glu
545                 550                 555                 560 
Arg Phe Val Met Val Ala Arg Met Leu Pro Glu Asp Ile Lys Arg Phe
                565                 570                 575     
Ala Ser Ile Val Ile Ala Asn Gly Arg Leu Leu Phe Lys Arg Asn Cys
            580                 585                 590         
Glu Lys Glu Glu Thr Val Gln Leu Thr Pro Asn Ala Glu Phe Lys Cys
        595                 600                 605             
Glu Lys Tyr Ile Gln Pro Pro Gln Arg Glu Thr Glu Ser His Gln Lys
    610                 615                 620                 
Ser Thr Pro Ser Thr Lys Gln Arg Glu Asp Glu His Ser Ser Glu Leu
625                 630                 635                 640 
Leu Lys Lys Asn Arg Ala Asn Ile Cys Gly Gln Val Ser Ser Glu Phe
                645                 650                 655     
Gln Val Ile Glu Lys Gly Ala Ser Ile Val Thr Trp Ser Ser Gly Tyr
            660                 665                 670         


<210> 8486
<211> 351
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 287
<223> Xaa = Any Amino Acid

<400> 8486
Met Thr Glu Met Ser Phe Leu Ser Ser Glu Val Leu Val Gly Asp Leu
 1               5                  10                  15      
Met Ser Pro Phe Asp Gln Ser Gly Leu Gly Ala Glu Glu Ser Leu Gly
            20                  25                  30          
Leu Leu Asp Asn Tyr Leu Glu Val Ala Lys His Phe Lys Pro His Gly
        35                  40                  45              
Phe Ser Arg Asp Lys Ala Lys Ala Gly Phe Ser Glu Trp Leu Ala Val
    50                  55                  60                  
Asp Gly Leu Gly Ser Pro Ser Asn Asn Ser Lys Glu Asp Ala Phe Ser
65                  70                  75                  80  
Gly Thr Asp Trp Met Leu Glu Lys Met Asp Leu Lys Glu Phe Val Phe
                85                  90                  95      
Asp Ala Leu Leu Gly Ile Asp Asn Leu Glu Thr Met Pro Asp Glu Leu
            100                 105                 110         
Leu Thr Thr Leu Asp Asp Thr Cys Asp Leu Phe Ala Pro Leu Val Gln
        115                 120                 125             
Glu Thr Asn Lys Glu Thr Pro Gln Thr Val Asn Pro Ile Gly His Leu
    130                 135                 140                 
Pro Gly Ser Leu Thr Lys Pro Asp Gln Val Ala Pro Phe Thr Phe Leu
145                 150                 155                 160 
Gln Pro Leu Pro Leu Ser Pro Gly Val Leu Ser Ser Thr Pro Gly His
                165                 170                 175     
Ser Phe Ser Leu Glu Leu Gly Ser Glu Val Asp Ile Pro Glu Gly Asp
            180                 185                 190         
Arg Lys Pro Asp Ser Thr Ala Tyr Val Ala Met Ile Pro Gln Cys Ile
        195                 200                 205             
Lys Glu Glu Asp Thr Pro Ser Asp Asn Asp Ser Gly Ile Cys Met Ser
    210                 215                 220                 
Pro Glu Ser Tyr Leu Gly Ser Pro Gln His Ser Pro Ser Thr Arg Gly
225                 230                 235                 240 
Ser Pro Asn Arg Ser Leu Pro Ser Pro Gly Val Leu Cys Gly Ser Ala
                245                 250                 255     
Arg Pro Lys Pro Tyr Asn Pro Pro Gly Glu Thr Met Val Ala Ala Lys
            260                 265                 270         
Val Lys Gly Glu Lys Leu Asp Lys Lys Leu Lys Lys Met Glu Xaa Asn
        275                 280                 285             
Lys Thr Ala Ala Thr Gly Tyr Arg Gln Lys Lys Arg Val Glu Gln Glu
    290                 295                 300                 
Ala Leu Thr Gly Glu Cys Lys Glu Leu Glu Lys Lys Asn Glu Ala Leu
305                 310                 315                 320 
Lys Glu Arg Ala Asp Ser Leu Ala Lys Glu Ile Gln Tyr Leu Lys Asp
                325                 330                 335     
Leu Ile Glu Glu Val Arg Lys Thr Arg Gly Lys Lys Arg Val Pro
            340                 345                 350     


<210> 8487
<211> 1146
<212> PRT
<213> Homo sapiens

<400> 8487
Met Lys Thr Pro Cys Ile Pro Ser Pro Lys Gln Gly Ser Lys Gly Arg
 1               5                  10                  15      
Gly Gln Ser Pro Ala Ala Gln Val Arg Gly Pro Thr Trp Asn Ala Pro
            20                  25                  30          
Ala Arg Glu Gly Arg Pro Gly Ala Gly His Leu Gly His Leu Arg Val
        35                  40                  45              
Gly Ala Cys Ala Arg Gly Ala Gln Ala Arg Ala Phe Phe Pro Phe Leu
    50                  55                  60                  
Ser Phe Leu Cys Tyr Pro Arg Phe Arg Cys Leu Phe Cys Leu Gln Phe
65                  70                  75                  80  
Ala Ile Pro Ala Ser Arg Met Glu Gln Leu Asn Glu Leu Glu Leu Leu
                85                  90                  95      
Met Glu Lys Ser Phe Trp Glu Glu Ala Glu Leu Pro Ala Glu Leu Phe
            100                 105                 110         
Gln Lys Lys Val Val Ala Ser Phe Pro Arg Thr Val Leu Ser Thr Gly
        115                 120                 125             
Met Asp Asn Arg Tyr Leu Val Leu Ala Val Asn Thr Val Gln Asn Lys
    130                 135                 140                 
Glu Gly Asn Cys Glu Lys Arg Leu Val Ile Thr Ala Ser Gln Ser Leu
145                 150                 155                 160 
Glu Asn Lys Glu Leu Cys Ile Leu Arg Asn Asp Trp Cys Ser Val Pro
                165                 170                 175     
Val Glu Pro Gly Asp Ile Ile His Leu Glu Gly Asp Cys Thr Ser Asp
            180                 185                 190         
Thr Trp Ile Ile Asp Lys Asp Phe Gly Tyr Leu Ile Leu Tyr Pro Asp
        195                 200                 205             
Met Leu Ile Ser Gly Thr Ser Ile Ala Ser Ser Ile Arg Cys Met Arg
    210                 215                 220                 
Arg Ala Val Leu Ser Glu Thr Phe Arg Ser Ser Asp Pro Ala Thr Arg
225                 230                 235                 240 
Gln Met Leu Ile Gly Thr Val Leu His Glu Val Phe Gln Lys Ala Ile
                245                 250                 255     
Asn Asn Ser Phe Ala Pro Glu Lys Leu Gln Glu Leu Ala Phe Gln Thr
            260                 265                 270         
Ile Gln Glu Ile Arg His Leu Lys Glu Met Tyr Arg Leu Asn Leu Ser
        275                 280                 285             
Gln Asp Glu Ile Lys Gln Glu Val Glu Asp Tyr Leu Pro Ser Phe Cys
    290                 295                 300                 
Lys Trp Ala Gly Asp Phe Met His Lys Asn Thr Ser Thr Asp Phe Pro
305                 310                 315                 320 
Gln Met Gln Leu Ser Leu Pro Ser Asp Asn Ser Lys Asp Asn Ser Thr
                325                 330                 335     
Cys Asn Ile Glu Val Val Lys Pro Met Asp Ile Glu Glu Ser Ile Trp
            340                 345                 350         
Ser Pro Arg Phe Gly Leu Lys Gly Lys Ile Asp Val Thr Val Gly Val
        355                 360                 365             
Lys Ile His Arg Gly Tyr Lys Thr Lys Tyr Lys Ile Met Pro Leu Glu
    370                 375                 380                 
Leu Lys Thr Gly Lys Glu Ser Asn Ser Ile Glu His Arg Ser Gln Val
385                 390                 395                 400 
Val Leu Tyr Thr Leu Leu Ser Gln Glu Arg Arg Ala Asp Pro Glu Ala
                405                 410                 415     
Gly Leu Leu Leu Tyr Leu Lys Thr Gly Gln Met Tyr Pro Val Pro Ala
            420                 425                 430         
Asn His Leu Asp Lys Arg Glu Leu Leu Lys Leu Arg Asn Gln Met Ala
        435                 440                 445             
Phe Ser Leu Phe His Arg Ile Ser Lys Ser Ala Thr Arg Gln Lys Thr
    450                 455                 460                 
Gln Leu Ala Ser Leu Pro Gln Ile Ile Glu Glu Glu Lys Thr Cys Lys
465                 470                 475                 480 
Tyr Cys Ser Gln Ile Gly Asn Cys Ala Leu Tyr Ser Arg Ala Val Glu
                485                 490                 495     
Gln Gln Met Asp Cys Ser Ser Val Pro Ile Val Met Leu Pro Lys Ile
            500                 505                 510         
Glu Glu Glu Thr Gln His Leu Lys Gln Thr His Leu Glu Tyr Phe Ser
        515                 520                 525             
Leu Trp Cys Leu Met Leu Thr Leu Glu Ser Gln Ser Lys Asp Asn Lys
    530                 535                 540                 
Lys Asn His Gln Asn Ile Trp Leu Met Pro Ala Ser Glu Met Glu Lys
545                 550                 555                 560 
Ser Gly Ser Cys Ile Gly Asn Leu Ile Arg Met Glu His Val Lys Ile
                565                 570                 575     
Val Cys Asp Gly Gln Tyr Leu His Asn Phe Gln Cys Lys His Gly Ala
            580                 585                 590         
Ile Pro Val Thr Asn Leu Met Ala Gly Asp Arg Val Ile Val Ser Gly
        595                 600                 605             
Glu Glu Arg Ser Leu Phe Ala Leu Ser Arg Gly Tyr Val Lys Glu Ile
    610                 615                 620                 
Asn Met Thr Thr Val Thr Cys Leu Leu Asp Arg Asn Leu Ser Val Leu
625                 630                 635                 640 
Pro Glu Ser Thr Leu Phe Arg Leu Asp Gln Glu Glu Lys Asn Cys Asp
                645                 650                 655     
Ile Asp Thr Pro Leu Gly Asn Leu Ser Lys Leu Met Glu Asn Thr Phe
            660                 665                 670         
Val Ser Lys Lys Leu Arg Asp Leu Ile Ile Asp Phe Arg Glu Pro Gln
        675                 680                 685             
Phe Ile Ser Tyr Leu Ser Ser Val Leu Pro His Asp Ala Lys Asp Thr
    690                 695                 700                 
Val Ala Cys Ile Leu Lys Gly Leu Asn Lys Pro Gln Arg Gln Ala Met
705                 710                 715                 720 
Lys Lys Val Leu Leu Ser Lys Asp Tyr Thr Leu Ile Val Gly Met Pro
                725                 730                 735     
Gly Thr Gly Lys Thr Thr Thr Ile Cys Thr Leu Val Arg Ile Leu Tyr
            740                 745                 750         
Ala Cys Gly Phe Ser Val Leu Leu Thr Ser Tyr Thr His Ser Ala Val
        755                 760                 765             
Asp Asn Ile Leu Leu Lys Leu Ala Lys Phe Lys Ile Gly Phe Leu Arg
    770                 775                 780                 
Leu Gly Gln Ile Gln Lys Val His Pro Ala Ile Gln Gln Phe Thr Glu
785                 790                 795                 800 
Gln Glu Ile Cys Arg Ser Lys Ser Ile Lys Ser Leu Ala Leu Leu Glu
                805                 810                 815     
Glu Leu Tyr Asn Ser Gln Leu Ile Val Ala Thr Thr Cys Met Gly Ile
            820                 825                 830         
Asn His Pro Ile Phe Ser Arg Lys Ile Phe Asp Phe Cys Ile Val Asp
        835                 840                 845             
Glu Ala Ser Gln Ile Ser Gln Pro Ile Cys Leu Gly Pro Leu Phe Phe
    850                 855                 860                 
Ser Arg Arg Phe Val Leu Val Gly Asp His Gln Gln Leu Pro Pro Leu
865                 870                 875                 880 
Val Leu Asn Arg Glu Ala Arg Ala Leu Gly Met Ser Glu Ser Leu Phe
                885                 890                 895     
Lys Arg Leu Glu Gln Asn Lys Ser Ala Val Val Gln Leu Thr Val Gln
            900                 905                 910         
Tyr Arg Met Asn Ser Lys Ile Met Ser Leu Ser Asn Lys Leu Thr Tyr
        915                 920                 925             
Glu Gly Lys Leu Glu Cys Gly Ser Asp Lys Val Ala Asn Ala Val Ile
    930                 935                 940                 
Asn Leu Arg His Phe Lys Asp Val Lys Leu Glu Leu Glu Phe Tyr Ala
945                 950                 955                 960 
Asp Tyr Ser Asp Asn Pro Trp Leu Met Gly Val Phe Glu Pro Asn Asn
                965                 970                 975     
Pro Val Cys Phe Leu Asn Thr Asp Lys Val Pro Ala Pro Glu Gln Val
            980                 985                 990         
Glu Lys Gly Gly Val Ser Asn Val Thr Glu Ala Lys Leu Ile Val Phe
        995                 1000                1005            
Leu Thr Ser Ile Phe Val Lys Ala Gly Cys Ser Pro Ser Asp Ile Gly
    1010                1015                1020                
Ile Ile Ala Pro Tyr Arg Gln Gln Leu Lys Ile Ile Asn Asp Leu Leu
1025                1030                1035                1040
Ala Arg Ser Ile Gly Met Val Glu Val Asn Thr Val Asp Lys Tyr Gln
                1045                1050                1055    
Gly Arg Asp Lys Ser Ile Val Leu Val Ser Phe Val Arg Ser Asn Lys
            1060                1065                1070        
Asp Gly Thr Val Gly Glu Leu Leu Lys Asp Trp Arg Arg Leu Asn Val
        1075                1080                1085            
Ala Ile Thr Arg Ala Lys His Lys Leu Ile Leu Leu Gly Cys Val Pro
    1090                1095                1100                
Ser Leu Asn Cys Tyr Pro Pro Leu Glu Lys Leu Leu Asn His Leu Asn
1105                1110                1115                1120
Ser Glu Lys Leu Ile Ile Asp Leu Pro Ser Arg Glu His Glu Ser Leu
                1125                1130                1135    
Cys His Ile Leu Gly Asp Phe Gln Arg Glu
            1140                1145    


<210> 8488
<211> 358
<212> PRT
<213> Homo sapiens

<400> 8488
Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val
 1               5                  10                  15      
Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys
            20                  25                  30          
His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr
        35                  40                  45              
Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val
    50                  55                  60                  
Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp
65                  70                  75                  80  
Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu
                85                  90                  95      
Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala
            100                 105                 110         
Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser
        115                 120                 125             
Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val
    130                 135                 140                 
Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala
145                 150                 155                 160 
Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser
                165                 170                 175     
Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu
            180                 185                 190         
Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala
        195                 200                 205             
Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala
    210                 215                 220                 
Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser
225                 230                 235                 240 
Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser
                245                 250                 255     
Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln
            260                 265                 270         
Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala
        275                 280                 285             
Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Thr Arg Asn Ala Glu Leu
    290                 295                 300                 
Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu Ala Arg Ala
305                 310                 315                 320 
Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala Gln Leu Leu
                325                 330                 335     
Asp Val Ser Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly Leu Ala Arg
            340                 345                 350         
Leu Ala Glu Ala Ala Pro
        355             


<210> 8489
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8489
Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val
 1               5                  10                  15      
Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys
            20                  25                  30          
His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr
        35                  40                  45              
Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val
    50                  55                  60                  
Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp
65                  70                  75                  80  
Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu
                85                  90                  95      
Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala
            100                 105                 110         
Ala Arg Leu Ala Arg Gln Leu Gln Arg
        115                 120     


<210> 8490
<211> 325
<212> PRT
<213> Homo sapiens

<400> 8490
Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val
 1               5                  10                  15      
Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys
            20                  25                  30          
His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr
        35                  40                  45              
Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val
    50                  55                  60                  
Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp
65                  70                  75                  80  
Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu
                85                  90                  95      
Gln His Leu Thr Gln Val Pro Pro Ser Pro Leu Val Ser Ala Asn Gly
            100                 105                 110         
Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala Asp Ala Pro Gly
        115                 120                 125             
Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser Glu Gly Ser Val
    130                 135                 140                 
Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu Gln Asp Ser Asn
145                 150                 155                 160 
Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala Ala Ala Ala Gln
                165                 170                 175     
Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala Glu Arg Leu Arg
            180                 185                 190         
Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser Glu Val Thr Pro
        195                 200                 205             
Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser Leu Glu Gln Leu
    210                 215                 220                 
Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln Thr Leu Lys Ser
225                 230                 235                 240 
Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala Glu Arg Glu Glu
                245                 250                 255     
Thr Gln Gln Lys Val Gln Asp Leu Glu Thr Arg Asn Ala Glu Leu Glu
            260                 265                 270         
His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu Ala Arg Ala Glu
        275                 280                 285             
Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala Gln Leu Leu Asp
    290                 295                 300                 
Val Arg Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly Leu Ala Arg Leu
305                 310                 315                 320 
Ala Glu Ala Ala Pro
                325 


<210> 8491
<211> 146
<212> PRT
<213> Homo sapiens

<400> 8491
Thr Leu Ser Pro Arg Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His
 1               5                  10                  15      
Val Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly
            20                  25                  30          
Lys His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val
        35                  40                  45              
Tyr Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr
    50                  55                  60                  
Val Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln
65                  70                  75                  80  
Trp Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser
                85                  90                  95      
Glu Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu
            100                 105                 110         
Ala Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Trp Gly Gly Pro
        115                 120                 125             
Gln Ser Ala Leu Val Val Gly Ser Phe Gly Ala Val Phe Glu Leu Leu
    130                 135                 140                 
Ile Val
145     


<210> 8492
<211> 361
<212> PRT
<213> Homo sapiens

<400> 8492
Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val
 1               5                  10                  15      
Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys
            20                  25                  30          
His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr
        35                  40                  45              
Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val
    50                  55                  60                  
Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp
65                  70                  75                  80  
Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu
                85                  90                  95      
Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala
            100                 105                 110         
Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser
        115                 120                 125             
Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val
    130                 135                 140                 
Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala
145                 150                 155                 160 
Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser
                165                 170                 175     
Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu
            180                 185                 190         
Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala
        195                 200                 205             
Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala
    210                 215                 220                 
Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser
225                 230                 235                 240 
Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser
                245                 250                 255     
Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln
            260                 265                 270         
Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala
        275                 280                 285             
Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Asp Leu Glu Thr Arg Asn
    290                 295                 300                 
Ala Glu Leu Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu
305                 310                 315                 320 
Ala Arg Ala Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala
                325                 330                 335     
Gln Leu Leu Asp Val Ser Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly
            340                 345                 350         
Leu Ala Arg Leu Ala Glu Ala Ala Pro
        355                 360     


<210> 8493
<211> 161
<212> PRT
<213> Homo sapiens

<400> 8493
Met Ile His Leu Pro Arg Leu Pro Lys Val Leu Gly Leu Gln Val Gly
 1               5                  10                  15      
Ala Thr Ala Pro Gly Leu Thr Thr Thr Lys Ile Pro Lys Arg Arg Ile
            20                  25                  30          
Gly Ser Ser Cys Gly Leu Leu Glu Gly Lys Asn Gly Ser Lys Ser Trp
        35                  40                  45              
Gly Ser Cys Ala Arg Thr Arg Ser Pro Val Arg Ala Ala Lys Ala Ile
    50                  55                  60                  
Glu Ser Gly Thr Glu Trp Asn Leu Ser Leu Leu Lys Leu Leu Arg Met
65                  70                  75                  80  
Thr Pro Gly Pro Gly Lys Met Ile Leu Ser Trp Ser Ser Leu His Leu
                85                  90                  95      
Cys Ile Ser Arg Thr Asp Val Pro Pro Val Lys Gly Ala Gly Ser Pro
            100                 105                 110         
Phe Val Thr Gln Ala Gly Val Gln Trp Arg Asp His Asp Ser Leu Gln
        115                 120                 125             
Ala Ser Thr Ser Gln Ala Gln Val Ile Leu Leu Asn Ser Trp Asp His
    130                 135                 140                 
Arg Asn Thr Asn Ser Arg Met Ala Pro Ser Leu Leu Lys Thr Ser Ile
145                 150                 155                 160 
Asn
    


<210> 8494
<211> 394
<212> PRT
<213> Homo sapiens

<400> 8494
Met Ala Leu Glu Val Gly Asp Met Glu Asp Gly Gln Leu Ser Asp Ser
 1               5                  10                  15      
Asp Ser Asp Met Thr Val Ala Pro Ser Asp Arg Pro Leu Gln Leu Pro
            20                  25                  30          
Lys Val Leu Gly Gly Asp Ser Ala Met Arg Ala Phe Gln Asn Thr Ala
        35                  40                  45              
Thr Ala Cys Ala Pro Val Ser His Tyr Arg Ala Val Glu Ser Val Asp
    50                  55                  60                  
Ser Ser Glu Glu Ser Phe Ser Asp Ser Asp Asp Asp Ser Cys Leu Trp
65                  70                  75                  80  
Lys Arg Lys Arg Gln Lys Cys Phe Asn Pro Pro Pro Lys Pro Glu Pro
                85                  90                  95      
Phe Gln Phe Gly Gln Ser Ser Gln Lys Pro Pro Val Ala Gly Gly Lys
            100                 105                 110         
Lys Ile Asn Asn Ile Trp Gly Ala Val Leu Gln Glu Gln Asn Gln Asp
        115                 120                 125             
Ala Val Ala Thr Glu Leu Gly Ile Leu Gly Met Glu Gly Thr Ile Asp
    130                 135                 140                 
Arg Ser Arg Gln Ser Glu Thr Tyr Asn Tyr Leu Leu Ala Lys Lys Leu
145                 150                 155                 160 
Arg Lys Glu Ser Gln Glu His Thr Lys Asp Leu Asp Lys Glu Leu Asp
                165                 170                 175     
Glu Tyr Met His Gly Gly Lys Lys Met Gly Ser Lys Glu Glu Glu Asn
            180                 185                 190         
Gly Gln Gly His Leu Lys Arg Lys Arg Pro Val Lys Asp Arg Leu Gly
        195                 200                 205             
Asn Arg Pro Glu Met Asn Tyr Lys Gly Arg Tyr Glu Ile Thr Ala Glu
    210                 215                 220                 
Asp Ser Gln Glu Lys Val Ala Asp Glu Ile Ser Phe Arg Leu Gln Glu
225                 230                 235                 240 
Pro Lys Lys Asp Leu Ile Ala Arg Val Val Arg Ile Ile Gly Asn Lys
                245                 250                 255     
Lys Ala Ile Glu Leu Leu Met Glu Thr Ala Glu Val Glu Gln Asn Gly
            260                 265                 270         
Gly Leu Phe Ile Met Asn Gly Ser Arg Arg Arg Thr Pro Gly Gly Val
        275                 280                 285             
Phe Leu Asn Leu Leu Lys Asn Thr Pro Ser Ile Ser Glu Glu Gln Ile
    290                 295                 300                 
Lys Asp Ile Phe Tyr Ile Glu Asn Gln Lys Glu Tyr Glu Asn Lys Lys
305                 310                 315                 320 
Ala Ala Arg Lys Arg Arg Thr Gln Val Leu Gly Lys Lys Met Lys Gln
                325                 330                 335     
Ala Ile Lys Ser Leu Asn Phe Gln Glu Asp Asp Asp Thr Ser Arg Glu
            340                 345                 350         
Thr Phe Ala Ser Asp Thr Asn Glu Ala Leu Ala Ser Leu Asp Glu Ser
        355                 360                 365             
Gln Glu Gly His Ala Glu Ala Lys Leu Glu Ala Glu Glu Ala Ile Glu
    370                 375                 380                 
Val Asp His Ser His Asp Leu Asp Ile Phe
385                 390                 


<210> 8495
<211> 430
<212> PRT
<213> Homo sapiens

<400> 8495
Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn
 1               5                  10                  15      
Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys
            20                  25                  30          
Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg
        35                  40                  45              
Arg Asp Ile Ser Ser Thr Leu Ile Ala Leu Ala Asp Lys His Ala Thr
    50                  55                  60                  
Leu Ser Val Cys Tyr Lys Ala Gly Pro Gly Ala Asp Asn Gly Glu Glu
65                  70                  75                  80  
Gly Glu Ile Glu Glu Glu Met Glu Asn Pro Glu Met Val Asp Leu Pro
                85                  90                  95      
Glu Lys Leu Lys His Gln Leu Arg His Arg Glu Leu Phe Leu Ser Arg
            100                 105                 110         
Gln Leu Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val
        115                 120                 125             
Thr Leu Leu Asn Glu Thr Glu Ser Leu Lys Ser Tyr Leu Glu Arg Glu
    130                 135                 140                 
Asp Phe Phe Phe Tyr Ser Leu Val Tyr Asp Pro Gln Gln Lys Thr Leu
145                 150                 155                 160 
Leu Ala Asp Lys Gly Glu Ile Arg Val Gly Asn Arg Tyr Gln Ala Asp
                165                 170                 175     
Ile Thr Asp Leu Leu Lys Glu Gly Glu Glu Asp Gly Arg Asp Gln Ser
            180                 185                 190         
Arg Leu Glu Thr Gln Val Trp Glu Ala His Asn Pro Leu Thr Asp Lys
        195                 200                 205             
Gln Ile Asp Gln Phe Leu Val Val Ala Arg Ser Val Gly Thr Phe Ala
    210                 215                 220                 
Arg Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met
225                 230                 235                 240 
Ser Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp
                245                 250                 255     
Thr Leu His Lys Asn Ile Tyr Asp Ile Ser Lys Ala Ile Ser Ala Leu
            260                 265                 270         
Val Pro Gln Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp
        275                 280                 285             
Ser Ala Ser Glu Ala Asn Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly
    290                 295                 300                 
Lys Asp Phe Thr Asp Ile Gln Gln Asp Phe Leu Pro Trp Lys Ser Leu
305                 310                 315                 320 
Thr Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr
                325                 330                 335     
Val Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys
            340                 345                 350         
Gln Val Tyr Ile Pro Asn Tyr Asn Lys Pro Asn Pro Asn Gln Ile Ser
        355                 360                 365             
Val Asn Asn Val Lys Ala Gly Val Val Asn Gly Thr Gly Ala Pro Gly
    370                 375                 380                 
Gln Ser Pro Gly Ala Gly Arg Ala Cys Glu Ser Cys Tyr Met Ser Ser
385                 390                 395                 400 
Leu Arg Ile Leu Leu Asp Ile Leu Glu Glu Ile Trp Trp Leu Glu Asn
                405                 410                 415     
Ala Asn Pro Val Arg Trp Arg Glu Ala Arg Thr Lys Pro Gln
            420                 425                 430 


<210> 8496
<211> 543
<212> PRT
<213> Homo sapiens

<400> 8496
Met Glu Gly Pro Ala Gly Tyr Leu Arg Arg Ala Ser Val Ala Gln Leu
 1               5                  10                  15      
Thr Gln Glu Leu Gly Thr Ala Phe Phe Gln Gln Gln Gln Leu Pro Ala
            20                  25                  30          
Ala Met Ala Asp Thr Phe Leu Glu His Leu Cys Leu Leu Asp Ile Asp
        35                  40                  45              
Ser Glu Pro Val Ala Ala Arg Ser Thr Ser Ile Ile Ala Thr Ile Gly
    50                  55                  60                  
Pro Ala Ser Arg Ser Val Glu Arg Leu Lys Glu Met Ile Lys Ala Gly
65                  70                  75                  80  
Met Asn Ile Ala Arg Leu Asn Phe Ser His Gly Ser His Glu Tyr His
                85                  90                  95      
Ala Glu Ser Ile Ala Asn Val Arg Glu Ala Val Glu Ser Phe Ala Gly
            100                 105                 110         
Ser Pro Leu Ser Tyr Arg Pro Val Ala Ile Ala Leu Asp Thr Lys Gly
        115                 120                 125             
Pro Glu Ile Arg Thr Gly Ile Leu Gln Gly Gly Pro Glu Ser Glu Val
    130                 135                 140                 
Glu Leu Val Lys Gly Ser Gln Val Leu Val Thr Val Asp Pro Ala Phe
145                 150                 155                 160 
Arg Thr Arg Gly Asn Ala Asn Thr Val Trp Val Asp Tyr Pro Asn Ile
                165                 170                 175     
Val Arg Val Val Pro Val Gly Gly Arg Ile Tyr Ile Asp Asp Gly Leu
            180                 185                 190         
Ile Ser Leu Val Val Gln Lys Ile Gly Pro Glu Gly Leu Val Thr Gln
        195                 200                 205             
Val Glu Asn Gly Gly Val Leu Gly Ser Arg Lys Gly Val Asn Leu Pro
    210                 215                 220                 
Gly Ala Gln Val Asp Leu Pro Gly Leu Ser Glu Gln Asp Val Arg Asp
225                 230                 235                 240 
Leu Arg Phe Gly Val Glu His Gly Val Asp Ile Val Phe Ala Ser Phe
                245                 250                 255     
Val Arg Lys Ala Ser Asp Val Ala Ala Val Arg Ala Ala Leu Gly Pro
            260                 265                 270         
Glu Gly His Gly Ile Lys Ile Ile Ser Lys Ile Glu Asn His Glu Gly
        275                 280                 285             
Val Lys Arg Phe Asp Glu Ile Leu Glu Val Ser Asp Gly Ile Met Val
    290                 295                 300                 
Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys Val Phe Leu
305                 310                 315                 320 
Ala Gln Lys Met Met Ile Gly Arg Cys Asn Leu Ala Gly Lys Pro Val
                325                 330                 335     
Val Cys Ala Thr Gln Met Leu Glu Ser Met Ile Thr Lys Pro Arg Pro
            340                 345                 350         
Thr Arg Ala Glu Thr Ser Asp Val Ala Asn Ala Val Leu Asp Gly Ala
        355                 360                 365             
Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly Asn Phe Pro Val
    370                 375                 380                 
Glu Ala Val Lys Met Gln His Ala Ile Ala Arg Glu Ala Glu Ala Ala
385                 390                 395                 400 
Val Tyr His Arg Gln Leu Phe Glu Glu Leu Arg Arg Ala Ala Pro Leu
                405                 410                 415     
Ser Arg Asp Pro Thr Glu Val Thr Ala Ile Gly Ala Val Glu Ala Ala
            420                 425                 430         
Phe Lys Cys Cys Ala Ala Ala Ile Ile Val Leu Thr Thr Thr Gly Arg
        435                 440                 445             
Ser Ala Gln Leu Leu Ser Arg Tyr Arg Pro Arg Ala Ala Val Ile Ala
    450                 455                 460                 
Val Thr Arg Ser Ala Gln Ala Ala Arg Gln Val His Leu Cys Arg Gly
465                 470                 475                 480 
Val Phe Pro Leu Leu Tyr Arg Glu Pro Pro Glu Ala Ile Trp Ala Asp
                485                 490                 495     
Asp Val Asp Arg Arg Val Gln Phe Gly Ile Glu Ser Gly Lys Leu Arg
            500                 505                 510         
Gly Phe Leu Arg Val Gly Asp Leu Val Ile Val Val Thr Gly Trp Arg
        515                 520                 525             
Pro Gly Ser Gly Tyr Thr Asn Ile Met Arg Val Leu Ser Ile Ser
    530                 535                 540             


<210> 8497
<211> 604
<212> PRT
<213> Homo sapiens

<400> 8497
Met Ser Ile Gln Glu Asn Ile Ser Ser Leu Gln Leu Arg Ser Trp Val
 1               5                  10                  15      
Ser Lys Ser Gln Arg Asp Leu Ala Lys Ser Ile Leu Ile Gly Ala Pro
            20                  25                  30          
Gly Ala Gln Leu Gly Leu Met Pro Leu Thr Thr Gln Gln Cys Gly Ala
        35                  40                  45              
Asp Pro Gln Arg Gly Arg Pro Arg Glu Val Cys Ser Gly Met Glu Gly
    50                  55                  60                  
Pro Ala Gly Tyr Leu Arg Arg Ala Ser Val Ala Gln Leu Thr Gln Glu
65                  70                  75                  80  
Leu Gly Thr Ala Phe Phe Gln Gln Gln Gln Leu Pro Ala Ala Met Ala
                85                  90                  95      
Asp Thr Phe Leu Glu His Leu Cys Leu Leu Asp Ile Asp Ser Glu Pro
            100                 105                 110         
Val Ala Ala Arg Ser Thr Ser Ile Ile Ala Thr Ile Gly Pro Ala Ser
        115                 120                 125             
Arg Ser Val Glu Arg Leu Lys Glu Met Ile Lys Ala Gly Met Asn Ile
    130                 135                 140                 
Ala Arg Leu Asn Phe Ser His Gly Ser His Glu Tyr His Ala Glu Ser
145                 150                 155                 160 
Ile Ala Asn Val Arg Glu Ala Val Glu Ser Phe Ala Gly Ser Pro Leu
                165                 170                 175     
Ser Tyr Arg Pro Val Ala Ile Ala Leu Asp Thr Lys Gly Pro Glu Ile
            180                 185                 190         
Arg Thr Gly Ile Leu Gln Gly Gly Pro Glu Ser Glu Val Glu Leu Val
        195                 200                 205             
Lys Gly Ser Gln Val Leu Val Thr Val Asp Pro Ala Phe Arg Thr Arg
    210                 215                 220                 
Gly Asn Ala Asn Thr Val Trp Val Asp Tyr Pro Asn Ile Val Arg Val
225                 230                 235                 240 
Val Pro Val Gly Gly Arg Ile Tyr Ile Asp Asp Gly Leu Ile Ser Leu
                245                 250                 255     
Val Val Gln Lys Ile Gly Pro Glu Gly Leu Val Thr Gln Val Glu Asn
            260                 265                 270         
Gly Gly Val Leu Gly Ser Arg Lys Gly Val Asn Leu Pro Gly Ala Gln
        275                 280                 285             
Val Asp Leu Pro Gly Leu Ser Glu Gln Asp Val Arg Asp Leu Arg Phe
    290                 295                 300                 
Gly Val Glu His Gly Val Asp Ile Val Phe Ala Ser Phe Val Arg Lys
305                 310                 315                 320 
Ala Ser Asp Val Ala Ala Val Arg Ala Ala Leu Gly Pro Glu Gly His
                325                 330                 335     
Gly Ile Lys Ile Ile Ser Lys Ile Glu Asn His Glu Gly Val Lys Arg
            340                 345                 350         
Phe Asp Glu Ile Leu Glu Val Ser Asp Gly Ile Met Val Ala Arg Gly
        355                 360                 365             
Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys Val Phe Leu Ala Gln Lys
    370                 375                 380                 
Met Met Ile Gly Arg Cys Asn Leu Ala Gly Lys Pro Val Val Cys Ala
385                 390                 395                 400 
Thr Gln Met Leu Glu Ser Met Ile Thr Lys Pro Arg Pro Thr Arg Ala
                405                 410                 415     
Glu Thr Ser Asp Val Ala Asn Ala Val Leu Asp Gly Ala Asp Cys Ile
            420                 425                 430         
Met Leu Ser Gly Glu Thr Ala Lys Gly Asn Phe Pro Val Glu Ala Val
        435                 440                 445             
Lys Met Gln His Ala Ile Ala Arg Glu Ala Glu Ala Ala Val Tyr His
    450                 455                 460                 
Arg Gln Leu Phe Glu Glu Leu Arg Arg Ala Ala Pro Leu Ser Arg Asp
465                 470                 475                 480 
Pro Thr Glu Val Thr Ala Ile Gly Ala Val Glu Ala Ala Phe Lys Cys
                485                 490                 495     
Cys Ala Ala Ala Ile Ile Val Leu Thr Thr Thr Gly Arg Ser Ala Gln
            500                 505                 510         
Leu Leu Ser Arg Tyr Arg Pro Arg Ala Ala Val Ile Ala Val Thr Arg
        515                 520                 525             
Ser Ala Gln Ala Ala Arg Gln Val His Leu Cys Arg Gly Val Phe Pro
    530                 535                 540                 
Leu Leu Tyr Arg Glu Pro Pro Glu Ala Ile Trp Ala Asp Asp Val Asp
545                 550                 555                 560 
Arg Arg Val Gln Phe Gly Ile Glu Ser Gly Lys Leu Arg Gly Phe Leu
                565                 570                 575     
Arg Val Gly Asp Leu Val Ile Val Val Thr Gly Trp Arg Pro Gly Ser
            580                 585                 590         
Gly Tyr Thr Asn Ile Met Arg Val Leu Ser Ile Ser
        595                 600                 


<210> 8498
<211> 574
<212> PRT
<213> Homo sapiens

<400> 8498
Met Ser Ile Gln Glu Asn Ile Ser Ser Leu Gln Leu Arg Ser Trp Val
 1               5                  10                  15      
Ser Lys Ser Gln Arg Asp Leu Ala Lys Ser Ile Leu Ile Gly Ala Pro
            20                  25                  30          
Gly Gly Pro Ala Gly Tyr Leu Arg Arg Ala Ser Val Ala Gln Leu Thr
        35                  40                  45              
Gln Glu Leu Gly Thr Ala Phe Phe Gln Gln Gln Gln Leu Pro Ala Ala
    50                  55                  60                  
Met Ala Asp Thr Phe Leu Glu His Leu Cys Leu Leu Asp Ile Asp Ser
65                  70                  75                  80  
Glu Pro Val Ala Ala Arg Ser Thr Ser Ile Ile Ala Thr Ile Gly Pro
                85                  90                  95      
Ala Ser Arg Ser Val Glu Arg Leu Lys Glu Met Ile Lys Ala Gly Met
            100                 105                 110         
Asn Ile Ala Arg Leu Asn Phe Ser His Gly Ser His Glu Tyr His Ala
        115                 120                 125             
Glu Ser Ile Ala Asn Val Arg Glu Ala Val Glu Ser Phe Ala Gly Ser
    130                 135                 140                 
Pro Leu Ser Tyr Arg Pro Val Ala Ile Ala Leu Asp Thr Lys Gly Pro
145                 150                 155                 160 
Glu Ile Arg Thr Gly Ile Leu Gln Gly Gly Pro Glu Ser Glu Val Glu
                165                 170                 175     
Leu Val Lys Gly Ser Gln Val Leu Val Thr Val Asp Pro Ala Phe Arg
            180                 185                 190         
Thr Arg Gly Asn Ala Asn Thr Val Trp Val Asp Tyr Pro Asn Ile Val
        195                 200                 205             
Arg Val Val Pro Val Gly Gly Arg Ile Tyr Ile Asp Asp Gly Leu Ile
    210                 215                 220                 
Ser Leu Val Val Gln Lys Ile Gly Pro Glu Gly Leu Val Thr Gln Val
225                 230                 235                 240 
Glu Asn Gly Gly Val Leu Gly Ser Arg Lys Gly Val Asn Leu Pro Gly
                245                 250                 255     
Ala Gln Val Asp Leu Pro Gly Leu Ser Glu Gln Asp Val Arg Asp Leu
            260                 265                 270         
Arg Phe Gly Val Glu His Gly Val Asp Ile Val Phe Ala Ser Phe Val
        275                 280                 285             
Arg Lys Ala Ser Asp Val Ala Ala Val Arg Ala Ala Leu Gly Pro Glu
    290                 295                 300                 
Gly His Gly Ile Lys Ile Ile Ser Lys Ile Glu Asn His Glu Gly Val
305                 310                 315                 320 
Lys Arg Phe Asp Glu Ile Leu Glu Val Ser Asp Gly Ile Met Val Ala
                325                 330                 335     
Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys Val Phe Leu Ala
            340                 345                 350         
Gln Lys Met Met Ile Gly Arg Cys Asn Leu Ala Gly Lys Pro Val Val
        355                 360                 365             
Cys Ala Thr Gln Met Leu Glu Ser Met Ile Thr Lys Pro Arg Pro Thr
    370                 375                 380                 
Arg Ala Glu Thr Ser Asp Val Ala Asn Ala Val Leu Asp Gly Ala Asp
385                 390                 395                 400 
Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly Asn Phe Pro Val Glu
                405                 410                 415     
Ala Val Lys Met Gln His Ala Ile Ala Arg Glu Ala Glu Ala Ala Val
            420                 425                 430         
Tyr His Arg Gln Leu Phe Glu Glu Leu Arg Arg Ala Ala Pro Leu Ser
        435                 440                 445             
Arg Asp Pro Thr Glu Val Thr Ala Ile Gly Ala Val Glu Ala Ala Phe
    450                 455                 460                 
Lys Cys Cys Ala Ala Ala Ile Ile Val Leu Thr Thr Thr Gly Arg Ser
465                 470                 475                 480 
Ala Gln Leu Leu Ser Arg Tyr Arg Pro Arg Ala Ala Val Ile Ala Val
                485                 490                 495     
Thr Arg Ser Ala Gln Ala Ala Arg Gln Val His Leu Cys Arg Gly Val
            500                 505                 510         
Phe Pro Leu Leu Tyr Arg Glu Pro Pro Glu Ala Ile Trp Ala Asp Asp
        515                 520                 525             
Val Asp Arg Arg Val Gln Phe Gly Ile Glu Ser Gly Lys Leu Arg Gly
    530                 535                 540                 
Phe Leu Arg Val Gly Asp Leu Val Ile Val Val Thr Gly Trp Arg Pro
545                 550                 555                 560 
Gly Ser Gly Tyr Thr Asn Ile Met Arg Val Leu Ser Ile Ser
                565                 570                 


<210> 8499
<211> 1213
<212> PRT
<213> Homo sapiens

<400> 8499
Met Arg Ser Arg Asn Gln Gly Gly Glu Ser Ala Ser Asp Gly His Ile
 1               5                  10                  15      
Ser Cys Pro Lys Pro Ser Ile Ile Gly Asn Ala Gly Glu Lys Ser Leu
            20                  25                  30          
Ser Glu Asp Ala Lys Lys Lys Lys Lys Ser Asn Arg Lys Glu Asp Asp
        35                  40                  45              
Val Met Ala Ser Gly Thr Val Lys Arg His Leu Lys Thr Ser Gly Glu
    50                  55                  60                  
Cys Glu Arg Lys Thr Lys Lys Ser Leu Glu Leu Ser Lys Glu Asp Leu
65                  70                  75                  80  
Ile Gln Leu Leu Ser Ile Met Glu Gly Glu Leu Gln Ala Arg Glu Asp
                85                  90                  95      
Val Ile His Met Leu Lys Thr Glu Lys Thr Lys Pro Glu Val Leu Glu
            100                 105                 110         
Ala His Tyr Gly Ser Ala Glu Pro Glu Lys Val Leu Arg Val Leu His
        115                 120                 125             
Arg Asp Ala Ile Leu Ala Gln Glu Lys Ser Ile Gly Glu Asp Val Tyr
    130                 135                 140                 
Glu Lys Pro Ile Ser Glu Leu Asp Arg Leu Glu Glu Lys Gln Lys Glu
145                 150                 155                 160 
Thr Tyr Arg Arg Met Leu Glu Gln Leu Leu Leu Ala Glu Lys Cys His
                165                 170                 175     
Arg Arg Thr Val Tyr Glu Leu Glu Asn Glu Lys His Lys His Thr Asp
            180                 185                 190         
Tyr Met Asn Lys Ser Asp Asp Phe Thr Asn Leu Leu Glu Gln Glu Arg
        195                 200                 205             
Glu Arg Leu Lys Lys Leu Leu Glu Gln Glu Lys Ala Tyr Gln Ala Arg
    210                 215                 220                 
Lys Glu Lys Glu Asn Ala Lys Arg Leu Asn Lys Leu Arg Asp Glu Leu
225                 230                 235                 240 
Val Lys Leu Lys Ser Phe Ala Leu Met Leu Val Asp Glu Arg Gln Met
                245                 250                 255     
His Ile Glu Gln Leu Gly Leu Gln Ser Gln Lys Val Gln Asp Leu Thr
            260                 265                 270         
Gln Lys Leu Arg Glu Glu Glu Glu Lys Leu Lys Ala Ile Thr Ser Lys
        275                 280                 285             
Ser Lys Glu Asp Arg Gln Lys Leu Leu Lys Leu Glu Val Asp Phe Glu
    290                 295                 300                 
His Lys Ala Ser Arg Phe Ser Gln Glu His Glu Glu Met Asn Ala Lys
305                 310                 315                 320 
Leu Ala Asn Gln Glu Ser His Asn Arg Gln Leu Arg Leu Lys Leu Val
                325                 330                 335     
Gly Leu Thr Gln Arg Ile Glu Glu Leu Glu Glu Thr Asn Lys Asn Leu
            340                 345                 350         
Gln Lys Ala Glu Glu Glu Leu Gln Glu Leu Arg Asp Lys Ile Ala Lys
        355                 360                 365             
Gly Glu Cys Gly Asn Ser Ser Leu Met Ala Glu Val Glu Asn Leu Arg
    370                 375                 380                 
Lys Arg Val Leu Glu Met Glu Gly Lys Asp Glu Glu Ile Thr Lys Thr
385                 390                 395                 400 
Glu Ser Gln Cys Arg Glu Leu Arg Lys Lys Leu Gln Glu Glu Glu His
                405                 410                 415     
His Ser Lys Glu Leu Arg Leu Glu Val Glu Lys Leu Gln Lys Arg Met
            420                 425                 430         
Ser Glu Leu Glu Lys Leu Glu Glu Ala Phe Ser Lys Ser Lys Ser Glu
        435                 440                 445             
Cys Thr Gln Leu His Leu Asn Leu Glu Lys Glu Lys Asn Leu Thr Lys
    450                 455                 460                 
Asp Leu Leu Asn Glu Leu Glu Val Val Lys Ser Arg Val Lys Glu Leu
465                 470                 475                 480 
Glu Cys Ser Glu Ser Arg Leu Glu Lys Ala Glu Leu Ser Leu Lys Asp
                485                 490                 495     
Asp Leu Thr Lys Leu Lys Ser Phe Thr Val Met Leu Val Asp Glu Arg
            500                 505                 510         
Lys Asn Met Met Glu Lys Ile Lys Gln Glu Glu Arg Lys Val Asp Gly
        515                 520                 525             
Leu Asn Lys Asn Phe Lys Val Glu Gln Gly Lys Val Met Asp Val Thr
    530                 535                 540                 
Glu Lys Leu Ile Glu Glu Ser Lys Lys Leu Leu Lys Leu Lys Ser Glu
545                 550                 555                 560 
Met Glu Glu Lys Val Tyr Asn Leu Thr Arg Glu Arg Asp Glu Leu Ile
                565                 570                 575     
Gly Lys Leu Lys Ser Glu Glu Glu Lys Ser Ser Glu Leu Ser Cys Ser
            580                 585                 590         
Val Asp Leu Leu Lys Lys Arg Leu Asp Gly Ile Glu Glu Val Glu Arg
        595                 600                 605             
Glu Ile Thr Arg Gly Arg Ser Arg Lys Gly Ser Glu Leu Thr Cys Pro
    610                 615                 620                 
Glu Asp Asn Lys Ile Lys Glu Leu Thr Leu Glu Ile Glu Arg Leu Lys
625                 630                 635                 640 
Lys Arg Leu Gln Gln Leu Glu Val Val Glu Gly Asp Leu Met Lys Thr
                645                 650                 655     
Glu Asp Glu Tyr Asp Gln Leu Glu Gln Lys Phe Arg Thr Glu Gln Asp
            660                 665                 670         
Lys Ala Asn Phe Leu Ser Gln Gln Leu Glu Glu Ile Lys His Gln Ile
        675                 680                 685             
Ala Lys Asn Lys Ala Ile Glu Lys Gly Glu Val Val Ser Gln Glu Ala
    690                 695                 700                 
Glu Leu Arg His Arg Phe Arg Leu Glu Glu Ala Lys Ser Arg Asp Leu
705                 710                 715                 720 
Lys Ala Glu Val Gln Ala Leu Lys Glu Lys Ile His Glu Leu Met Asn
                725                 730                 735     
Lys Glu Asp Gln Leu Ser Gln Leu Gln Val Asp Tyr Ser Val Leu Gln
            740                 745                 750         
Gln Arg Phe Met Glu Glu Glu Asn Lys Asn Lys Asn Met Gly Gln Glu
        755                 760                 765             
Val Leu Asn Leu Thr Lys Glu Leu Glu Leu Ser Lys Arg Tyr Ser Arg
    770                 775                 780                 
Ala Leu Arg Pro Ser Val Asn Gly Arg Arg Met Val Asp Val Pro Val
785                 790                 795                 800 
Thr Ser Thr Gly Val Gln Thr Asp Ala Val Ser Gly Glu Ala Ala Glu
                805                 810                 815     
Glu Glu Thr Pro Ala Val Phe Ile Arg Lys Ser Phe Gln Glu Glu Asn
            820                 825                 830         
His Ile Met Ser Asn Leu Arg Gln Val Gly Leu Lys Lys Pro Val Glu
        835                 840                 845             
Arg Ser Ser Val Leu Asp Arg Tyr Pro Pro Ala Ala Asn Glu Leu Thr
    850                 855                 860                 
Met Arg Lys Ser Trp Ile Pro Trp Met Arg Lys Arg Glu Asn Gly Pro
865                 870                 875                 880 
Ser Ile Thr Gln Glu Lys Gly Pro Arg Thr Asn Ser Ser Pro Gly His
                885                 890                 895     
Pro Gly Glu Val Val Leu Ser Pro Lys Gln Gly Gln Pro Leu His Ile
            900                 905                 910         
Arg Val Thr Pro Asp His Glu Asn Ser Thr Ala Thr Leu Glu Ile Thr
        915                 920                 925             
Ser Pro Thr Ser Glu Glu Phe Phe Ser Ser Thr Thr Val Ile Pro Thr
    930                 935                 940                 
Leu Gly Asn Gln Lys Pro Arg Ile Thr Ile Ile Pro Ser Pro Asn Val
945                 950                 955                 960 
Met Pro Gln Lys Gln Lys Ser Gly Asp Thr Thr Leu Gly Pro Glu Arg
                965                 970                 975     
Ala Met Ser Pro Val Thr Ile Thr Thr Phe Ser Arg Glu Lys Thr Pro
            980                 985                 990         
Glu Ser Gly Arg Gly Ala Phe Ala Asp Arg Pro Thr Ser Pro Ile Gln
        995                 1000                1005            
Ile Met Thr Val Ser Thr Ser Ala Ala Pro Ala Glu Ile Ala Val Ser
    1010                1015                1020                
Pro Glu Ser Gln Glu Met Pro Met Gly Arg Thr Ile Leu Lys Val Thr
1025                1030                1035                1040
Pro Glu Lys Gln Thr Val Pro Thr Pro Val Arg Lys Tyr Asn Ser Asn
                1045                1050                1055    
Ala Asn Ile Ile Thr Thr Glu Asp Asn Lys Ile His Ile His Leu Gly
            1060                1065                1070        
Ser Gln Phe Lys Arg Ser Pro Gly Thr Ser Gly Glu Gly Val Ser Pro
        1075                1080                1085            
Val Ile Thr Val Arg Pro Val Asn Val Thr Ala Glu Lys Glu Val Ser
    1090                1095                1100                
Thr Gly Thr Val Leu Arg Ser Pro Arg Asn His Leu Ser Ser Arg Pro
1105                1110                1115                1120
Gly Ala Ser Lys Val Thr Ser Thr Ile Thr Ile Thr Pro Val Thr Thr
                1125                1130                1135    
Ser Ser Ala Arg Gly Thr Gln Ser Val Ser Gly Gln Asp Gly Ser Ser
            1140                1145                1150        
Gln Arg Pro Thr Pro Thr Arg Ile Pro Met Ser Lys Gly Met Lys Ala
        1155                1160                1165            
Gly Lys Pro Val Val Ala Ala Pro Gly Ala Gly Asn Leu Thr Lys Phe
    1170                1175                1180                
Glu Pro Arg Ala Glu Thr Gln Ser Met Lys Ile Glu Leu Lys Lys Ser
1185                1190                1195                1200
Ala Ala Ser Ser Thr Thr Ser Leu Gly Gly Gly Lys Gly
                1205                1210            


<210> 8500
<211> 1917
<212> PRT
<213> Homo sapiens

<400> 8500
Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile Thr Ile Val Asp
 1               5                  10                  15      
Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln Ala Leu Gln Asp
            20                  25                  30          
Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro Asn Tyr Gly Cys
        35                  40                  45              
Gln Val Thr Ile Gln Ser Glu Gln Glu Lys Gln Leu Met Lys Gln Tyr
    50                  55                  60                  
Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys Lys Ala Gly Glu
65                  70                  75                  80  
Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp Pro Lys Glu Leu
                85                  90                  95      
Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg Ser Val Pro Ile
            100                 105                 110         
Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile His Tyr Pro His
        115                 120                 125             
Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Thr Ser Ala Phe Ile Ala
    130                 135                 140                 
Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg Glu Asn Asn Lys
145                 150                 155                 160 
Leu Tyr Glu Glu Val Arg Ile Pro Tyr Ser Glu Pro Met Pro Leu Ser
                165                 170                 175     
Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp Glu Ile Gly Gln
            180                 185                 190         
Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile Gln Ser Ile Val
        195                 200                 205             
Phe Glu Thr Ala Tyr Asn Thr Asn Glu Asn Met Leu Ile Cys Ala Pro
    210                 215                 220                 
Thr Gly Ala Gly Lys Thr Asn Ile Ala Met Leu Thr Val Leu His Glu
225                 230                 235                 240 
Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys Asn Glu Phe Lys
                245                 250                 255     
Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala Glu Met Thr Asp
            260                 265                 270         
Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile Val Lys Glu Leu
        275                 280                 285             
Thr Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu Arg Thr Gln Met
    290                 295                 300                 
Leu Val Thr Thr Pro Glu Lys Trp Asp Val Val Thr Arg Lys Ser Val
305                 310                 315                 320 
Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu Ile Leu Asp Glu
                325                 330                 335     
Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu Glu Ser Ile Val
            340                 345                 350         
Ala Arg Thr Leu Arg Gln Val Glu Ser Thr Gln Ser Met Ile Arg Ile
        355                 360                 365             
Leu Gly Leu Ser Ala Thr Leu Pro Asn Tyr Leu Asp Val Ala Thr Phe
    370                 375                 380                 
Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe Asp Gly Arg Phe
385                 390                 395                 400 
Arg Pro Val Pro Leu Gly Gln Thr Phe Leu Gly Ile Lys Cys Ala Asn
                405                 410                 415     
Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys Tyr Glu Asn Val
            420                 425                 430         
Leu Lys Gln Val Lys Ala Gly His Gln Val Met Val Phe Val His Ala
        435                 440                 445             
Arg Asn Ala Thr Val Arg Thr Ala Met Ser Leu Ile Glu Arg Ala Lys
    450                 455                 460                 
Asn Cys Gly His Ile Pro Phe Phe Phe Pro Thr Gln Gly His Asp Tyr
465                 470                 475                 480 
Val Leu Ala Glu Lys Gln Val Gln Arg Ser Arg Asn Lys Gln Val Arg
                485                 490                 495     
Glu Leu Phe Pro Asp Gly Phe Ser Ile His His Ala Gly Met Leu Arg
            500                 505                 510         
Gln Asp Arg Asn Leu Val Glu Asn Leu Phe Ser Asn Gly His Ile Lys
        515                 520                 525             
Val Leu Val Cys Thr Ala Thr Leu Ala Trp Gly Val Asn Leu Pro Ala
    530                 535                 540                 
His Ala Val Ile Ile Lys Gly Thr Gln Ile Tyr Ala Ala Lys Arg Gly
545                 550                 555                 560 
Ser Phe Val Asp Leu Gly Ile Leu Asp Val Met Gln Ile Phe Gly Arg
                565                 570                 575     
Ala Gly Arg Pro Gln Phe Asp Lys Phe Gly Glu Gly Ile Ile Ile Thr
            580                 585                 590         
Thr His Asp Lys Leu Ser His Tyr Leu Thr Leu Leu Thr Gln Arg Asn
        595                 600                 605             
Pro Ile Glu Ser Gln Phe Leu Glu Ser Leu Ala Asp Asn Leu Asn Ala
    610                 615                 620                 
Glu Ile Ala Leu Gly Thr Val Thr Asn Val Glu Glu Ala Val Lys Trp
625                 630                 635                 640 
Ile Ser Tyr Thr Tyr Leu Tyr Val Arg Met Arg Ala Asn Pro Leu Ala
                645                 650                 655     
Tyr Gly Ile Ser His Lys Ala Tyr Gln Ile Asp Pro Thr Leu Arg Lys
            660                 665                 670         
His Arg Glu Gln Leu Val Ile Glu Val Gly Arg Lys Leu Asp Lys Ala
        675                 680                 685             
Gln Met Ile Arg Phe Glu Glu Arg Thr Gly Tyr Phe Ser Ser Thr Asp
    690                 695                 700                 
Leu Gly Arg Thr Ala Ser His Tyr Tyr Ile Lys Tyr Asn Thr Ile Glu
705                 710                 715                 720 
Thr Phe Asn Glu Leu Phe Asp Ala His Lys Thr Glu Gly Asp Ile Phe
                725                 730                 735     
Ala Ile Val Ser Lys Ala Glu Glu Phe Asp Gln Ile Lys Val Arg Glu
            740                 745                 750         
Glu Glu Ile Glu Glu Leu Asp Thr Leu Leu Ser Asn Phe Cys Glu Leu
        755                 760                 765             
Ser Thr Pro Gly Gly Val Glu Asn Ser Tyr Gly Lys Ile Asn Ile Leu
    770                 775                 780                 
Leu Gln Thr Tyr Ile Ser Arg Gly Glu Met Asp Ser Phe Ser Leu Ile
785                 790                 795                 800 
Ser Asp Ser Ala Tyr Val Ala Gln Asn Ala Ala Arg Ile Val Arg Ala
                805                 810                 815     
Leu Phe Glu Ile Ala Leu Arg Lys Arg Trp Pro Thr Met Thr Tyr Arg
            820                 825                 830         
Leu Leu Asn Leu Ser Lys Val Ile Asp Lys Arg Leu Trp Gly Trp Ala
        835                 840                 845             
Ser Pro Leu Arg Gln Phe Ser Ile Leu Pro Pro His Ile Leu Thr Arg
    850                 855                 860                 
Leu Glu Glu Lys Lys Leu Thr Val Asp Lys Leu Lys Asp Met Arg Lys
865                 870                 875                 880 
Asp Glu Ile Gly His Ile Leu His His Val Asn Ile Gly Leu Lys Val
                885                 890                 895     
Lys Gln Cys Val His Gln Ile Pro Ser Val Met Met Glu Ala Ser Ile
            900                 905                 910         
Gln Pro Ile Thr Arg Thr Val Leu Arg Val Thr Leu Ser Ile Tyr Ala
        915                 920                 925             
Asp Phe Thr Trp Asn Asp Gln Val His Gly Thr Val Gly Glu Pro Trp
    930                 935                 940                 
Trp Ile Trp Val Glu Asp Pro Thr Asn Asp His Ile Tyr His Ser Glu
945                 950                 955                 960 
Tyr Phe Leu Ala Leu Lys Lys Gln Val Ile Ser Lys Glu Ala Gln Leu
                965                 970                 975     
Leu Val Phe Thr Ile Pro Ile Phe Glu Pro Leu Pro Ser Gln Tyr Tyr
            980                 985                 990         
Ile Arg Ala Val Ser Asp Arg Trp Leu Gly Ala Glu Ala Val Cys Ile
        995                 1000                1005            
Ile Asn Phe Gln His Leu Ile Leu Pro Glu Arg His Pro Pro His Thr
    1010                1015                1020                
Glu Leu Leu Asp Leu Gln Pro Leu Pro Ile Thr Ala Leu Gly Cys Lys
1025                1030                1035                1040
Ala Tyr Glu Ala Leu Tyr Asn Phe Ser His Phe Asn Pro Val Gln Thr
                1045                1050                1055    
Gln Ile Phe His Thr Leu Tyr His Thr Asp Cys Asn Val Leu Leu Gly
            1060                1065                1070        
Ala Pro Thr Gly Ser Gly Lys Thr Val Ala Ala Glu Leu Ala Ile Phe
        1075                1080                1085            
Arg Val Phe Asn Lys Tyr Pro Thr Ser Lys Ala Val Tyr Ile Ala Pro
    1090                1095                1100                
Leu Lys Ala Leu Val Arg Glu Arg Met Asp Asp Trp Lys Val Arg Ile
1105                1110                1115                1120
Glu Glu Lys Leu Gly Lys Lys Val Ile Glu Leu Thr Gly Asp Val Thr
                1125                1130                1135    
Pro Asp Met Lys Ser Ile Ala Lys Ala Asp Leu Ile Val Thr Thr Pro
            1140                1145                1150        
Glu Lys Trp Asp Gly Val Ser Arg Ser Trp Gln Asn Arg Asn Tyr Val
        1155                1160                1165            
Gln Gln Val Thr Ile Leu Ile Ile Asp Glu Ile His Leu Leu Gly Glu
    1170                1175                1180                
Glu Arg Gly Pro Val Leu Glu Val Ile Val Ser Arg Thr Asn Phe Ile
1185                1190                1195                1200
Ser Ser His Thr Glu Lys Pro Val Arg Ile Val Gly Leu Ser Thr Ala
                1205                1210                1215    
Leu Ala Asn Ala Arg Asp Leu Ala Asp Trp Leu Asn Ile Lys Gln Met
            1220                1225                1230        
Gly Leu Phe Asn Phe Arg Pro Ser Val Arg Pro Val Pro Leu Glu Val
        1235                1240                1245            
His Ile Gln Gly Phe Pro Gly Gln His Tyr Cys Pro Arg Met Ala Ser
    1250                1255                1260                
Met Asn Lys Pro Ala Phe Gln Ala Ile Arg Ser His Ser Pro Ala Lys
1265                1270                1275                1280
Pro Val Leu Ile Phe Val Ser Ser Arg Arg Gln Thr Arg Leu Thr Ala
                1285                1290                1295    
Leu Glu Leu Ile Ala Phe Leu Ala Thr Glu Glu Asp Pro Lys Gln Trp
            1300                1305                1310        
Leu Asn Met Asp Glu Arg Glu Met Glu Asn Ile Ile Ala Thr Val Arg
        1315                1320                1325            
Asp Ser Asn Leu Lys Leu Thr Leu Ala Phe Gly Ile Gly Met His His
    1330                1335                1340                
Ala Gly Leu His Glu Arg Asp Arg Lys Thr Val Glu Glu Leu Phe Val
1345                1350                1355                1360
Asn Cys Lys Val Gln Val Leu Ile Ala Thr Ser Thr Leu Ala Trp Gly
                1365                1370                1375    
Val Asn Phe Pro Ala His Leu Val Ile Ile Lys Gly Thr Glu Tyr Tyr
            1380                1385                1390        
Asp Gly Lys Thr Arg Arg Tyr Val Asp Phe Pro Ile Thr Asp Val Leu
        1395                1400                1405            
Gln Met Met Gly Arg Ala Gly Arg Pro Gln Phe Asp Asp Gln Gly Lys
    1410                1415                1420                
Ala Val Ile Leu Val His Asp Ile Lys Lys Asp Phe Tyr Lys Lys Phe
1425                1430                1435                1440
Leu Tyr Glu Pro Phe Pro Val Glu Ser Ser Leu Leu Gly Val Leu Ser
                1445                1450                1455    
Asp His Leu Asn Ala Glu Ile Ala Gly Gly Thr Ile Thr Ser Lys Gln
            1460                1465                1470        
Asp Ala Leu Asp Tyr Ile Thr Trp Thr Tyr Phe Phe Arg Arg Leu Ile
        1475                1480                1485            
Met Asn Pro Ser Tyr Tyr Asn Leu Gly Asp Val Ser His Asp Ser Val
    1490                1495                1500                
Asn Lys Phe Leu Ser His Leu Ile Glu Lys Ser Leu Ile Glu Leu Glu
1505                1510                1515                1520
Leu Ser Tyr Cys Ile Glu Ile Gly Glu Asp Asn Arg Ser Ile Glu Pro
                1525                1530                1535    
Leu Thr Tyr Gly Arg Ile Ala Ser Tyr Tyr Tyr Leu Lys His Gln Thr
            1540                1545                1550        
Val Lys Met Phe Lys Asp Arg Leu Lys Pro Glu Cys Ser Thr Glu Glu
        1555                1560                1565            
Leu Leu Ser Ile Leu Ser Asp Ala Glu Glu Tyr Thr Asp Leu Pro Val
    1570                1575                1580                
Arg His Asn Glu Asp His Met Asn Ser Glu Leu Ala Lys Cys Leu Pro
1585                1590                1595                1600
Ile Glu Ser Asn Pro His Ser Phe Asp Ser Pro His Thr Lys Ala His
                1605                1610                1615    
Leu Leu Leu Gln Ala His Leu Ser Arg Ala Met Leu Pro Cys Pro Asp
            1620                1625                1630        
Tyr Asp Thr Asp Thr Lys Thr Val Leu Asp Gln Ala Leu Arg Val Cys
        1635                1640                1645            
Gln Ala Met Leu Asp Val Ala Ala Asn Gln Gly Trp Leu Val Thr Val
    1650                1655                1660                
Leu Asn Ile Thr Asn Leu Ile Gln Met Val Ile Gln Gly Arg Trp Leu
1665                1670                1675                1680
Lys Asp Ser Ser Leu Leu Thr Leu Pro Asn Ile Glu Asn His His Leu
                1685                1690                1695    
His Leu Phe Lys Lys Trp Lys Pro Ile Met Lys Gly Pro His Ala Arg
            1700                1705                1710        
Gly Arg Thr Ser Ile Glu Cys Leu Pro Glu Leu Ile His Ala Cys Gly
        1715                1720                1725            
Gly Lys Asp His Val Phe Ser Ser Met Val Glu Ser Glu Leu His Ala
    1730                1735                1740                
Ala Lys Thr Lys Gln Ala Trp Asn Phe Leu Ser His Leu Pro Val Ile
1745                1750                1755                1760
Asn Val Gly Ile Ser Val Lys Gly Ser Trp Asp Asp Leu Val Glu Gly
                1765                1770                1775    
His Asn Glu Leu Ser Val Ser Thr Leu Thr Ala Asp Lys Arg Asp Asp
            1780                1785                1790        
Asn Lys Trp Ile Lys Leu His Ala Asp Gln Glu Tyr Val Leu Gln Val
        1795                1800                1805            
Ser Leu Gln Arg Val His Phe Gly Phe His Lys Gly Lys Pro Glu Ser
    1810                1815                1820                
Cys Ala Val Thr Pro Arg Phe Pro Lys Ser Lys Asp Glu Gly Trp Phe
1825                1830                1835                1840
Leu Ile Leu Gly Glu Val Asp Lys Arg Glu Leu Ile Ala Leu Lys Arg
                1845                1850                1855    
Val Gly Tyr Ile Arg Asn His His Val Ala Ser Leu Ser Phe Tyr Thr
            1860                1865                1870        
Pro Glu Ile Pro Gly Arg Tyr Ile Tyr Thr Leu Tyr Phe Met Ser Asp
        1875                1880                1885            
Cys Tyr Leu Gly Leu Asp Gln Gln Tyr Asp Asn Leu Ser Gln Arg Tyr
    1890                1895                1900                
Thr Ser Glu Ser Phe Cys Thr Gly Gln His Gln Gly Leu
1905                1910                1915        


<210> 8501
<211> 2202
<212> PRT
<213> Homo sapiens

<400> 8501
Met Ala Leu Pro Arg Leu Thr Gly Ala Leu Arg Ser Phe Ser Asn Val
 1               5                  10                  15      
Thr Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys
            20                  25                  30          
Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Thr Trp Lys
        35                  40                  45              
Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln
    50                  55                  60                  
Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile
65                  70                  75                  80  
Val Gly Thr Asp Asn Gly Arg Glu Ala Ile Glu Ser Gly Ala Ala Phe
                85                  90                  95      
Leu Phe Met Thr Phe His Leu Lys Asp Ser Val Gly His Lys Glu Thr
            100                 105                 110         
Lys Ala Ile Lys Gln Met Phe Gly Pro Phe Pro Ser Ser Ser Ala Thr
        115                 120                 125             
Ala Ala Cys Asn Ala Thr Asn Arg Ile Ile Ser His Phe Ser Gln Asp
    130                 135                 140                 
Asp Phe Thr Ala Leu Val Gln Met Thr Glu Lys Glu His Gly Asp Arg
145                 150                 155                 160 
Val Phe Phe Gly Lys Asn Leu Ala Phe Ser Phe Asp Met His Asp Leu
                165                 170                 175     
Asp His Phe Asp Glu Leu Pro Ile Asn Gly Glu Thr Gln Lys Thr Ile
            180                 185                 190         
Ser Leu Asp Tyr Lys Lys Phe Leu Asn Glu His Leu Gln Glu Ala Cys
        195                 200                 205             
Thr Pro Glu Leu Lys Pro Val Glu Lys Thr Asn Gly Ser Phe Leu Trp
    210                 215                 220                 
Cys Glu Val Glu Lys Tyr Leu Asn Ser Thr Leu Lys Glu Met Thr Glu
225                 230                 235                 240 
Val Pro Arg Val Glu Asp Leu Cys Cys Thr Leu Tyr Asp Met Leu Ala
                245                 250                 255     
Ser Ile Lys Ser Gly Asp Glu Leu Gln Asp Glu Leu Phe Glu Leu Leu
            260                 265                 270         
Gly Pro Glu Gly Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile
        275                 280                 285             
Thr Ile Val Asp Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln
    290                 295                 300                 
Ala Leu Gln Asp Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro
305                 310                 315                 320 
Asn Tyr Gly Cys Gln Val Thr Ile Gln Ser Glu Gln Glu Lys Gln Leu
                325                 330                 335     
Met Lys Gln Tyr Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys
            340                 345                 350         
Lys Ala Gly Glu Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp
        355                 360                 365             
Pro Lys Glu Leu Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg
    370                 375                 380                 
Ser Val Pro Ile Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile
385                 390                 395                 400 
His Tyr Pro His Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Thr Ser
                405                 410                 415     
Ala Phe Ile Ala Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg
            420                 425                 430         
Glu Asn Asn Lys Leu Tyr Glu Glu Val Arg Ile Ser Tyr Ser Glu Pro
        435                 440                 445             
Met Pro Leu Ser Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp
    450                 455                 460                 
Glu Ile Gly Gln Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile
465                 470                 475                 480 
Gln Ser Ile Val Phe Glu Thr Ala Tyr Asn Thr Asn Glu Asn Met Leu
                485                 490                 495     
Ile Cys Ala Pro Thr Gly Ala Gly Lys Thr Asn Ile Ala Met Leu Thr
            500                 505                 510         
Val Leu His Glu Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys
        515                 520                 525             
Asn Glu Phe Lys Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala
    530                 535                 540                 
Glu Met Thr Asp Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile
545                 550                 555                 560 
Val Lys Glu Leu Thr Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu
                565                 570                 575     
Arg Thr Gln Met Leu Val Thr Thr Pro Glu Lys Trp Asp Val Val Thr
            580                 585                 590         
Arg Lys Ser Val Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu
        595                 600                 605             
Ile Leu Asp Glu Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu
    610                 615                 620                 
Glu Ser Ile Val Ala Arg Thr Leu Arg Gln Val Glu Ser Thr Gln Ser
625                 630                 635                 640 
Met Ile Arg Ile Leu Gly Leu Ser Ala Thr Leu Pro Asn Tyr Leu Asp
                645                 650                 655     
Val Ala Thr Phe Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe
            660                 665                 670         
Asp Gly Arg Phe Arg Pro Val Pro Leu Gly Gln Thr Phe Leu Gly Ile
        675                 680                 685             
Lys Cys Ala Asn Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys
    690                 695                 700                 
Tyr Glu Asn Val Leu Lys Gln Val Lys Ala Gly His Gln Val Met Val
705                 710                 715                 720 
Phe Val His Ala Arg Asn Ala Thr Val Arg Thr Ala Met Ser Leu Ile
                725                 730                 735     
Glu Arg Ala Lys Asn Cys Gly His Ile Pro Phe Phe Phe Ser Thr Gln
            740                 745                 750         
Gly His Asp Tyr Val Leu Ala Glu Lys Gln Val Gln Arg Ser Arg Asn
        755                 760                 765             
Lys Gln Val Arg Glu Leu Phe Pro Asp Gly Phe Ser Ile His His Ala
    770                 775                 780                 
Gly Met Leu Arg Gln Asp Arg Asn Leu Val Glu Asn Leu Phe Ser Asn
785                 790                 795                 800 
Gly His Ile Lys Val Leu Val Cys Thr Ala Thr Leu Ala Trp Gly Val
                805                 810                 815     
Asn Leu Pro Ala His Ala Val Ile Ile Lys Gly Thr Gln Ile Tyr Ala
            820                 825                 830         
Ala Lys Arg Gly Ser Phe Val Asp Leu Gly Ile Leu Asp Val Met Gln
        835                 840                 845             
Ile Phe Gly Arg Ala Gly Arg Pro Gln Phe Asp Lys Phe Gly Glu Gly
    850                 855                 860                 
Ile Ile Ile Thr Thr His Asp Lys Leu Ser His Tyr Leu Thr Leu Leu
865                 870                 875                 880 
Thr Gln Arg Asn Pro Ile Glu Ser Gln Phe Leu Glu Ser Leu Ala Asp
                885                 890                 895     
Asn Leu Asn Ala Glu Ile Ala Leu Gly Thr Val Thr Asn Val Glu Glu
            900                 905                 910         
Ala Val Lys Trp Ile Ser Tyr Thr Tyr Leu Tyr Val Arg Met Arg Ala
        915                 920                 925             
Asn Pro Leu Ala Tyr Gly Ile Ser His Lys Ala Tyr Gln Ile Asp Pro
    930                 935                 940                 
Thr Leu Arg Lys His Arg Glu Gln Leu Val Ile Glu Val Gly Arg Lys
945                 950                 955                 960 
Leu Asp Lys Ala Gln Met Ile Arg Phe Glu Glu Arg Thr Gly Tyr Phe
                965                 970                 975     
Ser Ser Thr Asp Leu Gly Arg Thr Ala Ser His Tyr Tyr Ile Lys Tyr
            980                 985                 990         
Asn Thr Ile Glu Thr Phe Asn Glu Leu Phe Asp Ala His Lys Thr Glu
        995                 1000                1005            
Gly Asp Ile Phe Ala Ile Val Ser Lys Ala Glu Glu Phe Asp Gln Ile
    1010                1015                1020                
Lys Val Arg Glu Glu Glu Ile Glu Glu Leu Asp Thr Leu Leu Ser Asn
1025                1030                1035                1040
Phe Cys Glu Leu Ser Thr Pro Gly Gly Val Glu Asn Ser Tyr Gly Lys
                1045                1050                1055    
Ile Asn Ile Leu Leu Gln Thr Tyr Ile Ser Arg Gly Glu Met Asp Ser
            1060                1065                1070        
Phe Ser Leu Ile Ser Asp Ser Ala Tyr Val Ala Gln Asn Ala Ala Arg
        1075                1080                1085            
Ile Val Arg Ala Leu Phe Glu Ile Ala Leu Arg Lys Arg Trp Pro Thr
    1090                1095                1100                
Met Thr Tyr Arg Leu Leu Asn Leu Ser Lys Val Ile Asp Lys Arg Leu
1105                1110                1115                1120
Trp Gly Trp Ala Ser Pro Leu Arg Gln Phe Ser Ile Leu Pro Pro His
                1125                1130                1135    
Ile Leu Thr Arg Leu Glu Glu Lys Lys Leu Thr Val Asp Lys Leu Lys
            1140                1145                1150        
Asp Met Arg Lys Asp Glu Ile Gly His Ile Leu His His Val Asn Ile
        1155                1160                1165            
Gly Leu Lys Val Lys Gln Cys Val His Gln Ile Pro Ser Val Met Met
    1170                1175                1180                
Glu Ala Ser Ile Gln Pro Ile Thr Arg Thr Val Leu Arg Val Thr Leu
1185                1190                1195                1200
Ser Ile Tyr Ala Asp Phe Thr Trp Asn Asp Gln Val His Gly Thr Val
                1205                1210                1215    
Gly Glu Pro Trp Trp Ile Trp Val Glu Asp Pro Thr Asn Asp His Ile
            1220                1225                1230        
Tyr His Ser Glu Tyr Phe Leu Ala Leu Lys Lys Gln Val Ile Ser Lys
        1235                1240                1245            
Glu Ala Gln Leu Leu Val Phe Thr Ile Pro Ile Phe Glu Pro Leu Pro
    1250                1255                1260                
Ser Gln Tyr Tyr Ile Arg Ala Val Ser Asp Arg Trp Leu Gly Ala Glu
1265                1270                1275                1280
Ala Val Cys Ile Ile Asn Phe Gln His Leu Ile Leu Pro Glu Arg His
                1285                1290                1295    
Pro Pro His Thr Glu Leu Leu Asp Leu Gln Pro Leu Pro Ile Thr Ala
            1300                1305                1310        
Leu Gly Cys Lys Ala Tyr Glu Ala Leu Tyr Asn Phe Ser His Phe Asn
        1315                1320                1325            
Pro Val Gln Thr Gln Ile Phe His Thr Leu Tyr His Thr Asp Cys Asn
    1330                1335                1340                
Val Leu Leu Gly Ala Pro Thr Gly Ser Gly Lys Thr Val Ala Ala Glu
1345                1350                1355                1360
Leu Ala Ile Phe Arg Val Phe Asn Lys Tyr Pro Thr Ser Lys Ala Val
                1365                1370                1375    
Tyr Ile Ala Pro Leu Lys Ala Leu Val Arg Glu Arg Met Asp Asp Trp
            1380                1385                1390        
Lys Val Arg Ile Glu Glu Lys Leu Gly Lys Lys Val Ile Glu Leu Thr
        1395                1400                1405            
Gly Asp Val Thr Pro Asp Met Lys Ser Ile Ala Lys Ala Asp Leu Ile
    1410                1415                1420                
Val Thr Thr Pro Glu Lys Trp Asp Gly Val Ser Arg Ser Trp Gln Asn
1425                1430                1435                1440
Arg Asn Tyr Val Gln Gln Val Thr Ile Leu Ile Ile Asp Glu Ile His
                1445                1450                1455    
Leu Leu Gly Glu Glu Arg Gly Pro Val Leu Glu Val Ile Val Ser Arg
            1460                1465                1470        
Thr Asn Phe Ile Ser Ser His Thr Glu Lys Pro Val Arg Ile Val Gly
        1475                1480                1485            
Leu Ser Thr Ala Leu Ala Asn Ala Arg Asp Leu Ala Asp Trp Leu Asn
    1490                1495                1500                
Ile Lys Gln Met Gly Leu Phe Asn Phe Arg Pro Ser Val Arg Pro Val
1505                1510                1515                1520
Pro Leu Glu Val His Ile Gln Gly Phe Pro Gly Gln His Tyr Cys Pro
                1525                1530                1535    
Arg Met Ala Ser Met Asn Lys Pro Ala Phe Gln Ala Ile Arg Ser His
            1540                1545                1550        
Ser Pro Ala Lys Pro Val Leu Ile Phe Val Ser Ser Arg Arg Gln Thr
        1555                1560                1565            
Arg Leu Thr Ala Leu Glu Leu Ile Ala Phe Leu Ala Thr Glu Glu Asp
    1570                1575                1580                
Pro Lys Gln Trp Leu Asn Met Asp Glu Arg Glu Met Glu Asn Ile Ile
1585                1590                1595                1600
Ala Thr Val Arg Asp Ser Asn Leu Lys Leu Thr Leu Ala Phe Gly Ile
                1605                1610                1615    
Gly Met His His Ala Gly Leu His Glu Arg Asp Arg Lys Thr Val Glu
            1620                1625                1630        
Glu Leu Phe Val Asn Cys Lys Val Gln Val Leu Ile Ala Thr Ser Thr
        1635                1640                1645            
Leu Ala Trp Gly Val Asn Phe Pro Ala His Leu Val Ile Ile Lys Gly
    1650                1655                1660                
Thr Glu Tyr Tyr Asp Gly Lys Thr Arg Arg Tyr Val Asp Phe Pro Ile
1665                1670                1675                1680
Thr Asp Val Leu Gln Met Met Gly Arg Ala Gly Arg Pro Gln Phe Asp
                1685                1690                1695    
Asp Gln Gly Lys Ala Val Ile Leu Val His Asp Ile Lys Lys Asp Phe
            1700                1705                1710        
Tyr Lys Lys Phe Leu Tyr Glu Pro Phe Pro Val Glu Ser Ser Leu Leu
        1715                1720                1725            
Gly Val Leu Ser Asp His Leu Asn Ala Glu Ile Ala Gly Gly Thr Ile
    1730                1735                1740                
Thr Ser Lys Gln Asp Ala Leu Asp Tyr Ile Thr Trp Thr Tyr Phe Phe
1745                1750                1755                1760
Arg Arg Leu Ile Met Asn Pro Ser Tyr Tyr Asn Leu Gly Asp Val Ser
                1765                1770                1775    
His Asp Ser Val Asn Lys Phe Leu Ser His Leu Ile Glu Lys Ser Leu
            1780                1785                1790        
Ile Glu Leu Glu Leu Ser Tyr Cys Ile Glu Ile Gly Glu Asp Asn Arg
        1795                1800                1805            
Ser Ile Glu Pro Leu Thr Tyr Gly Arg Ile Ala Ser Tyr Tyr Tyr Leu
    1810                1815                1820                
Lys His Gln Thr Val Lys Met Phe Lys Asp Arg Leu Lys Pro Glu Cys
1825                1830                1835                1840
Ser Thr Glu Glu Leu Leu Ser Ile Leu Ser Asp Ala Glu Glu Tyr Thr
                1845                1850                1855    
Asp Leu Pro Val Arg His Asn Glu Asp His Met Asn Ser Glu Leu Ala
            1860                1865                1870        
Lys Cys Leu Pro Ile Glu Ser Asn Pro His Ser Phe Asp Ser Pro His
        1875                1880                1885            
Thr Lys Ala His Leu Leu Leu Gln Ala His Leu Ser Arg Ala Met Leu
    1890                1895                1900                
Pro Cys Pro Asp Tyr Asp Thr Asp Thr Lys Thr Val Leu Asp Gln Ala
1905                1910                1915                1920
Leu Arg Val Cys Gln Ala Met Leu Asp Val Ala Ala Asn Gln Gly Trp
                1925                1930                1935    
Leu Val Thr Val Leu Asn Ile Thr Asn Leu Ile Gln Met Val Ile Gln
            1940                1945                1950        
Gly Arg Trp Leu Lys Asp Ser Ser Leu Leu Thr Leu Pro Asn Ile Glu
        1955                1960                1965            
Asn His His Leu His Leu Phe Lys Lys Trp Lys Pro Ile Met Lys Gly
    1970                1975                1980                
Pro His Ala Arg Gly Arg Thr Ser Ile Glu Ser Leu Pro Glu Leu Ile
1985                1990                1995                2000
His Ala Cys Gly Gly Lys Asp His Val Phe Ser Ser Met Val Glu Ser
                2005                2010                2015    
Glu Leu His Ala Ala Lys Thr Lys Gln Ala Trp Asn Phe Leu Ser His
            2020                2025                2030        
Leu Pro Val Ile Asn Val Gly Ile Ser Val Lys Gly Ser Trp Asp Asp
        2035                2040                2045            
Leu Val Glu Gly His Asn Glu Leu Ser Val Ser Thr Leu Thr Ala Asp
    2050                2055                2060                
Lys Arg Asp Asp Asn Lys Trp Ile Lys Leu His Ala Asp Gln Glu Tyr
2065                2070                2075                2080
Val Leu Gln Val Ser Leu Gln Arg Val His Phe Gly Phe His Lys Gly
                2085                2090                2095    
Lys Pro Glu Ser Cys Ala Val Thr Pro Arg Phe Pro Lys Ser Lys Asp
            2100                2105                2110        
Glu Gly Trp Phe Leu Ile Leu Gly Glu Val Asp Lys Arg Glu Leu Ile
        2115                2120                2125            
Ala Leu Lys Arg Val Gly Tyr Ile Arg Asn His His Val Ala Ser Leu
    2130                2135                2140                
Ser Phe Tyr Thr Pro Glu Ile Pro Gly Arg Tyr Ile Tyr Thr Leu Tyr
2145                2150                2155                2160
Phe Met Ser Asp Cys Tyr Leu Gly Leu Asp Gln Gln Tyr Asp Ile Tyr
                2165                2170                2175    
Leu Asn Val Thr Gln Ala Ser Leu Ser Ala Gln Val Asn Thr Lys Val
            2180                2185                2190        
Ser Asp Ser Leu Thr Asp Leu Ala Leu Lys
        2195                2200        


<210> 8502
<211> 607
<212> PRT
<213> Homo sapiens

<400> 8502
Phe Val Cys Val Phe Gln Gly Leu Leu Thr Phe Arg Asp Val Ala Ile
 1               5                  10                  15      
Glu Phe Ser Pro Glu Glu Trp Gln Cys Leu Asp Thr Ala Gln Gln Asn
            20                  25                  30          
Leu Tyr Arg Asn Val Met Leu Glu Asn Tyr Arg Asn Leu Ala Phe Leu
        35                  40                  45              
Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Leu Trp Ser
    50                  55                  60                  
Ser Thr Leu Arg Arg His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr
65                  70                  75                  80  
Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser His Ser Ser Ala Leu Ala
                85                  90                  95      
Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu
            100                 105                 110         
Cys Gly Lys Ala Phe Ser Asn Ser Ser Thr Leu Ala Asn His Lys Ile
        115                 120                 125             
Thr His Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu Cys Asp Lys Thr
    130                 135                 140                 
Phe Lys Arg Leu Ser Thr Leu Thr Lys His Lys Ile Ile His Ala Gly
145                 150                 155                 160 
Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser
                165                 170                 175     
Ser Asn Leu Thr Ile His Lys Phe Ile His Thr Gly Glu Lys Pro Tyr
            180                 185                 190         
Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Ser Leu Thr
        195                 200                 205             
Lys His Lys Arg Ile His Thr Arg Glu Lys Pro Phe Lys Cys Lys Glu
    210                 215                 220                 
Cys Gly Lys Ala Phe Ile Trp Ser Ser Thr Leu Thr Arg His Lys Arg
225                 230                 235                 240 
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
                245                 250                 255     
Phe Ser Arg Ser Ser Thr Leu Thr Lys His Lys Thr Ile His Thr Gly
            260                 265                 270         
Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Lys His Ser
        275                 280                 285             
Ser Ala Leu Ala Lys His Lys Ile Ile His Ala Gly Glu Lys Leu Tyr
    290                 295                 300                 
Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Asn Leu Thr
305                 310                 315                 320 
Thr His Lys Ile Ile His Thr Lys Glu Lys Pro Ser Lys Ser Glu Glu
                325                 330                 335     
Cys Asp Lys Ala Phe Ile Trp Ser Ser Thr Leu Thr Glu His Lys Arg
            340                 345                 350         
Ile His Thr Arg Glu Lys Thr Tyr Lys Cys Glu Glu Cys Gly Lys Ala
        355                 360                 365             
Phe Ser Gln Pro Ser His Leu Thr Thr His Lys Arg Met His Thr Gly
    370                 375                 380                 
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Gln Ser
385                 390                 395                 400 
Ser Thr Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr
                405                 410                 415     
Lys Cys Glu Glu Cys Gly Lys Ala Phe Arg Lys Ser Ser Thr Leu Thr
            420                 425                 430         
Glu His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
        435                 440                 445             
Cys Gly Lys Ala Phe Ser Gln Ser Ser Thr Leu Thr Arg His Thr Arg
    450                 455                 460                 
Met His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
465                 470                 475                 480 
Phe Asn Arg Ser Ser Lys Leu Thr Thr His Lys Ile Ile His Thr Gly
                485                 490                 495     
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ile Ser Ser
            500                 505                 510         
Ser Thr Leu Asn Gly His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr
        515                 520                 525             
Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Thr Leu Thr
    530                 535                 540                 
Arg His Lys Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Gly Glu
545                 550                 555                 560 
Cys Gly Lys Ala Phe Lys Glu Ser Ser Ala Leu Thr Lys His Lys Ile
                565                 570                 575     
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala
            580                 585                 590         
Phe Asn Gln Ser Ser Ile Leu Thr Asn His Lys Lys Ile His Thr
        595                 600                 605         


<210> 8503
<211> 1191
<212> PRT
<213> Homo sapiens

<400> 8503
Met Pro Gly Thr Pro Gly Ser Leu Glu Met Gly Leu Leu Thr Phe Arg
 1               5                  10                  15      
Asp Val Ala Ile Glu Phe Ser Pro Glu Glu Trp Gln Cys Leu Asp Thr
            20                  25                  30          
Ala Gln Gln Asn Leu Tyr Arg Asn Val Met Leu Glu Asn Tyr Arg Asn
        35                  40                  45              
Leu Ala Phe Leu Gly Ile Ala Leu Ser Lys Pro Asp Leu Ile Thr Tyr
    50                  55                  60                  
Leu Glu Gln Gly Lys Glu Pro Trp Asn Met Lys Gln His Glu Met Val
65                  70                  75                  80  
Asp Glu Pro Thr Gly Ile Cys Pro His Phe Pro Gln Asp Phe Trp Pro
                85                  90                  95      
Glu Gln Ser Met Glu Asp Ser Phe Gln Lys Val Leu Leu Arg Lys Tyr
            100                 105                 110         
Glu Lys Cys Gly His Glu Asn Leu Gln Leu Arg Lys Gly Cys Lys Ser
        115                 120                 125             
Val Asp Glu Cys Lys Val His Lys Glu Gly Tyr Asn Lys Leu Asn Gln
    130                 135                 140                 
Cys Leu Thr Thr Ala Gln Ser Lys Val Phe Gln Cys Gly Lys Tyr Leu
145                 150                 155                 160 
Lys Val Phe Tyr Lys Phe Leu Asn Ser Asn Arg His Thr Ile Arg His
                165                 170                 175     
Thr Gly Lys Lys Cys Phe Lys Cys Lys Lys Cys Val Lys Ser Phe Cys
            180                 185                 190         
Ile Arg Leu His Lys Thr Gln His Lys Cys Val Tyr Ile Thr Glu Lys
        195                 200                 205             
Ser Cys Lys Cys Lys Glu Cys Glu Lys Thr Phe His Trp Ser Ser Thr
    210                 215                 220                 
Leu Thr Asn His Lys Glu Ile His Thr Glu Asp Lys Pro Tyr Lys Cys
225                 230                 235                 240 
Glu Glu Cys Gly Lys Ala Phe Lys Gln Leu Ser Thr Leu Thr Thr His
                245                 250                 255     
Lys Ile Ile Cys Ala Lys Glu Lys Ile Tyr Lys Cys Glu Glu Cys Gly
            260                 265                 270         
Lys Ala Phe Leu Trp Ser Ser Thr Leu Thr Arg His Lys Arg Ile His
        275                 280                 285             
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser
    290                 295                 300                 
His Ser Ser Thr Leu Ala Lys His Lys Arg Ile His Thr Gly Glu Lys
305                 310                 315                 320 
Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser His Ser Ser Ala
                325                 330                 335     
Leu Ala Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
            340                 345                 350         
Lys Glu Cys Gly Lys Ala Phe Ser Asn Ser Ser Thr Leu Ala Asn His
        355                 360                 365             
Lys Ile Thr His Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu Cys Asp
    370                 375                 380                 
Lys Thr Phe Lys Arg Leu Ser Thr Leu Thr Lys His Lys Ile Ile His
385                 390                 395                 400 
Ala Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
                405                 410                 415     
Arg Ser Ser Asn Leu Thr Ile His Lys Phe Ile His Thr Gly Glu Lys
            420                 425                 430         
Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Ser
        435                 440                 445             
Leu Thr Lys His Lys Arg Phe His Thr Arg Glu Lys Pro Phe Lys Cys
    450                 455                 460                 
Lys Glu Cys Gly Lys Gly Phe Ile Trp Ser Ser Thr Leu Thr Arg His
465                 470                 475                 480 
Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
                485                 490                 495     
Lys Ala Phe Arg Gln Ser Ser Thr Leu Thr Lys His Lys Ile Ile His
            500                 505                 510         
Thr Gly Glu Lys Pro Tyr Lys Phe Glu Glu Cys Gly Lys Ala Phe Arg
        515                 520                 525             
Gln Ser Leu Thr Leu Asn Lys His Lys Ile Ile His Ser Arg Glu Lys
    530                 535                 540                 
Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Lys Gln Phe Ser Thr
545                 550                 555                 560 
Leu Thr Thr His Lys Ile Ile His Ala Gly Lys Lys Leu Tyr Lys Cys
                565                 570                 575     
Glu Glu Cys Gly Lys Ala Phe Asn His Ser Ser Ser Leu Ser Thr His
            580                 585                 590         
Lys Ile Ile His Thr Gly Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly
        595                 600                 605             
Lys Ala Phe Leu Trp Ser Ser Thr Leu Arg Arg His Lys Arg Ile His
    610                 615                 620                 
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser
625                 630                 635                 640 
His Ser Ser Ala Leu Ala Lys His Lys Arg Ile His Thr Gly Glu Lys
                645                 650                 655     
Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Asn Ser Ser Thr
            660                 665                 670         
Leu Ala Asn His Lys Ile Thr His Thr Glu Glu Lys Pro Tyr Lys Cys
        675                 680                 685             
Lys Glu Cys Asp Lys Thr Phe Lys Arg Leu Ser Thr Leu Thr Lys His
    690                 695                 700                 
Lys Ile Ile His Ala Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly
705                 710                 715                 720 
Lys Ala Phe Asn Arg Ser Ser Asn Leu Thr Ile His Lys Phe Ile His
                725                 730                 735     
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
            740                 745                 750         
Trp Ser Ser Ser Leu Thr Lys His Lys Arg Ile His Thr Arg Glu Lys
        755                 760                 765             
Pro Phe Lys Cys Lys Glu Cys Gly Lys Ala Phe Ile Trp Ser Ser Thr
    770                 775                 780                 
Leu Thr Arg His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
785                 790                 795                 800 
Glu Glu Cys Gly Lys Ala Phe Ser Arg Ser Ser Thr Leu Thr Lys His
                805                 810                 815     
Lys Thr Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly
            820                 825                 830         
Lys Ala Phe Lys His Ser Ser Ala Leu Ala Lys His Lys Ile Ile His
        835                 840                 845             
Ala Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
    850                 855                 860                 
Gln Ser Ser Asn Leu Thr Thr His Lys Ile Ile His Thr Lys Glu Lys
865                 870                 875                 880 
Pro Ser Lys Ser Glu Glu Cys Asp Lys Ala Phe Ile Trp Ser Ser Thr
                885                 890                 895     
Leu Thr Glu His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys
            900                 905                 910         
Glu Glu Cys Gly Lys Ala Phe Ser Gln Pro Ser His Leu Thr Thr His
        915                 920                 925             
Lys Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
    930                 935                 940                 
Lys Ala Phe Ser Gln Ser Ser Thr Leu Thr Thr His Lys Ile Ile His
945                 950                 955                 960 
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Arg
                965                 970                 975     
Lys Ser Ser Thr Leu Thr Glu His Lys Ile Ile His Thr Gly Glu Lys
            980                 985                 990         
Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Thr
        995                 1000                1005            
Leu Thr Arg His Thr Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys
    1010                1015                1020                
Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Lys Leu Thr Thr His
1025                1030                1035                1040
Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
                1045                1050                1055    
Lys Ala Phe Ile Ser Ser Ser Thr Leu Asn Gly His Lys Arg Ile His
            1060                1065                1070        
Thr Arg Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser
        1075                1080                1085            
Gln Ser Ser Thr Leu Thr Arg His Lys Arg Leu His Thr Gly Glu Lys
    1090                1095                1100                
Pro Tyr Lys Cys Gly Glu Cys Gly Lys Ala Phe Lys Glu Ser Ser Ala
1105                1110                1115                1120
Leu Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
                1125                1130                1135    
Glu Lys Cys Cys Lys Ala Phe Asn Gln Ser Ser Ile Leu Thr Asn His
            1140                1145                1150        
Lys Lys Ile His Thr Ile Thr Pro Val Ile Pro Leu Leu Trp Glu Ala
        1155                1160                1165            
Glu Ala Gly Gly Ser Arg Gly Gln Glu Met Glu Thr Ile Leu Ala Asn
    1170                1175                1180                
Thr Val Lys Pro Leu Leu Tyr
1185                1190    


<210> 8504
<211> 538
<212> PRT
<213> Homo sapiens

<400> 8504
His Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu Cys Asp Lys Ala Phe
 1               5                  10                  15      
Lys Arg Leu Ser Thr Leu Thr Lys His Lys Ile Ile His Ala Gly Glu
            20                  25                  30          
Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser
        35                  40                  45              
Asn Leu Thr Ile His Lys Phe Ile His Thr Gly Glu Lys Pro Tyr Lys
    50                  55                  60                  
Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Ser Leu Thr Lys
65                  70                  75                  80  
His Lys Arg Phe His Thr Arg Glu Lys Pro Phe Lys Cys Lys Glu Cys
                85                  90                  95      
Gly Lys Ala Phe Ile Trp Ser Ser Thr Leu Thr Arg His Lys Arg Ile
            100                 105                 110         
His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe
        115                 120                 125             
Arg Gln Ser Ser Thr Leu Thr Lys His Lys Ile Ile His Thr Gly Glu
    130                 135                 140                 
Lys Pro Tyr Lys Phe Glu Glu Cys Gly Lys Ala Phe Arg Gln Ser Leu
145                 150                 155                 160 
Thr Leu Asn Lys His Lys Ile Ile His Ser Arg Glu Lys Pro Tyr Lys
                165                 170                 175     
Cys Lys Glu Cys Gly Lys Ala Phe Lys Gln Phe Ser Thr Leu Thr Thr
            180                 185                 190         
His Lys Ile Ile His Ala Gly Lys Lys Leu Tyr Lys Cys Glu Glu Cys
        195                 200                 205             
Gly Lys Ala Phe Asn His Ser Ser Ser Leu Ser Thr His Lys Ile Ile
    210                 215                 220                 
His Thr Gly Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe
225                 230                 235                 240 
Leu Trp Ser Ser Thr Leu Arg Arg His Lys Arg Ile His Thr Gly Glu
                245                 250                 255     
Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser His Ser Ser
            260                 265                 270         
Ala Leu Ala Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
        275                 280                 285             
Cys Lys Glu Cys Gly Lys Ala Phe Ser Asn Ser Ser Thr Leu Ala Asn
    290                 295                 300                 
His Lys Ile Thr His Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu Cys
305                 310                 315                 320 
Asp Lys Thr Phe Lys Arg Leu Ser Thr Leu Thr Lys His Lys Ile Ile
                325                 330                 335     
His Ala Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe
            340                 345                 350         
Asn Arg Ser Ser Asn Leu Thr Ile His Lys Phe Ile His Thr Gly Glu
        355                 360                 365             
Lys Pro Tyr Lys Glu Lys Thr Tyr Lys Cys Glu Glu Cys Gly Lys Ala
    370                 375                 380                 
Phe Ser Gln Pro Ser His Leu Thr Thr His Lys Arg Met His Thr Gly
385                 390                 395                 400 
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Gln Ser
                405                 410                 415     
Ser Thr Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr
            420                 425                 430         
Lys Cys Glu Glu Cys Gly Lys Ala Phe Arg Lys Ser Ser Thr Leu Thr
        435                 440                 445             
Glu His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu
    450                 455                 460                 
Cys Gly Lys Ala Phe Ser Gln Ser Ser Thr Leu Thr Arg His Thr Arg
465                 470                 475                 480 
Met His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
                485                 490                 495     
Phe Asn Arg Ser Ser Lys Leu Thr Thr His Lys Ile Ile His Thr Gly
            500                 505                 510         
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ile Ser Ser
        515                 520                 525             
Ser Thr Leu Asn Gly His Lys Arg Ile His
    530                 535             


<210> 8505
<211> 961
<212> PRT
<213> Homo sapiens

<400> 8505
Met Val Phe Gln Leu Lys Cys Gly Ser Gly Pro Val Tyr Ile Ser Gly
 1               5                  10                  15      
Gln His Leu Val Ser Val Glu Glu Asp Ala Glu Ser Glu Asp Glu Glu
            20                  25                  30          
Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Gln Ser Ala Leu
        35                  40                  45              
Glu Val Glu Ala Arg Phe His Lys Lys Asp Asp Ala Val Glu Pro Glu
    50                  55                  60                  
Pro His Arg Ser Arg Leu Pro Arg Ala Lys Pro Pro Leu Thr Ser Ala
65                  70                  75                  80  
Pro Gly Thr Ala Ala Pro Lys Leu Pro Leu Ser Pro Trp Gly Met Pro
                85                  90                  95      
Ala Gly Leu Thr Glu Pro Ala Gly Ala Ala Pro Pro Ala Ala Val Ser
            100                 105                 110         
Ala Ser Gly Thr Val Thr Met Ala Pro Ala Gly Ala Leu Pro Val Arg
        115                 120                 125             
Val Glu Ser Thr Pro Val Ala Leu Gly Ala Val Thr Lys Ala Pro Val
    130                 135                 140                 
Ser Val Cys Val Glu Pro Thr Ala Ser Gln Pro Leu Arg Ser Pro Val
145                 150                 155                 160 
Gly Thr Leu Val Thr Lys Val Ala Pro Val Ser Ala Pro Pro Lys Val
                165                 170                 175     
Ser Ser Gly Pro Arg Leu Pro Ala Pro Gln Ile Val Ala Val Lys Ala
            180                 185                 190         
Pro Asn Thr Thr Thr Ile Gln Phe Pro Ala Asn Leu Gln Leu Pro Pro
        195                 200                 205             
Gly Thr Val Leu Ile Lys Ser Asn Ser Gly Pro Leu Met Leu Val Ser
    210                 215                 220                 
Pro Gln Gln Thr Val Thr Arg Ala Glu Thr Thr Ser Asn Ile Thr Ser
225                 230                 235                 240 
Arg Pro Ala Val Pro Ala Asn Pro Gln Thr Val Lys Ile Cys Thr Val
                245                 250                 255     
Pro Asn Ser Ser Ser Gln Leu Ile Lys Lys Val Ala Val Thr Pro Val
            260                 265                 270         
Lys Lys Leu Ala Gln Ile Gly Thr Thr Val Val Thr Thr Val Pro Lys
        275                 280                 285             
Pro Ser Ser Val Gln Ser Val Ala Val Pro Thr Ser Val Val Thr Val
    290                 295                 300                 
Thr Pro Gly Lys Pro Leu Asn Thr Val Thr Thr Leu Lys Pro Ser Ser
305                 310                 315                 320 
Leu Gly Ala Ser Ser Thr Pro Ser Asn Glu Pro Asn Leu Lys Ala Glu
                325                 330                 335     
Asn Ser Ala Ala Val Gln Ile Asn Leu Ser Pro Thr Met Leu Glu Asn
            340                 345                 350         
Val Lys Lys Cys Lys Asn Phe Leu Ala Met Leu Ile Lys Leu Ala Cys
        355                 360                 365             
Ser Gly Ser Gln Ser Pro Glu Met Gly Gln Asn Val Lys Lys Leu Val
    370                 375                 380                 
Glu Gln Leu Leu Asp Ala Lys Ile Glu Ala Glu Glu Phe Thr Arg Lys
385                 390                 395                 400 
Leu Tyr Val Glu Leu Lys Ser Ser Pro Gln Pro His Leu Val Pro Phe
                405                 410                 415     
Leu Lys Lys Ser Val Val Ala Leu Arg Gln Leu Leu Pro Asn Ser Gln
            420                 425                 430         
Ser Phe Ile Gln Gln Cys Val Gln Gln Thr Ser Ser Asp Met Val Ile
        435                 440                 445             
Ala Thr Cys Thr Thr Thr Val Thr Thr Ser Pro Val Val Thr Thr Thr
    450                 455                 460                 
Val Ser Ser Ser Gln Ser Glu Lys Ser Ile Ile Val Ser Gly Ala Thr
465                 470                 475                 480 
Ala Pro Arg Thr Val Ser Val Gln Thr Leu Asn Pro Leu Ala Gly Pro
                485                 490                 495     
Val Gly Ala Lys Ala Gly Val Val Thr Leu His Ser Val Gly Pro Thr
            500                 505                 510         
Ala Ala Thr Gly Gly Thr Thr Ala Gly Thr Gly Leu Leu Gln Thr Ser
        515                 520                 525             
Lys Pro Leu Val Thr Ser Val Ala Asn Thr Val Thr Thr Val Ser Leu
    530                 535                 540                 
Gln Pro Glu Lys Pro Val Val Ser Gly Thr Ala Val Thr Leu Ser Leu
545                 550                 555                 560 
Pro Ala Val Thr Phe Gly Glu Thr Ser Gly Ala Ala Ile Cys Leu Pro
                565                 570                 575     
Ser Val Lys Pro Val Val Ser Ser Ala Gly Thr Thr Ser Asp Lys Pro
            580                 585                 590         
Val Ile Gly Thr Pro Val Gln Ile Lys Leu Ala Gln Pro Gly Pro Val
        595                 600                 605             
Leu Ser Gln Pro Ala Gly Ile Pro Gln Ala Val Gln Val Lys Gln Leu
    610                 615                 620                 
Phe Ser Leu Phe Gln Val Val Gln Gln Pro Ser Gly Gly Asn Glu Lys
625                 630                 635                 640 
Gln Val Thr Thr Ile Ser His Ser Ser Thr Leu Thr Ile Gln Lys Cys
                645                 650                 655     
Gly Gln Lys Thr Met Pro Val Asn Thr Ile Ile Pro Thr Ser Gln Phe
            660                 665                 670         
Pro Pro Ala Ser Ile Leu Lys Gln Ile Thr Leu Pro Gly Asn Lys Ile
        675                 680                 685             
Leu Ser Leu Gln Ala Ser Pro Thr Gln Lys Asn Arg Ile Lys Glu Asn
    690                 695                 700                 
Val Thr Ser Cys Phe Arg Asp Glu Asp Asp Ile Asn Asp Val Thr Ser
705                 710                 715                 720 
Met Ala Gly Val Asn Leu Asn Glu Glu Asn Ala Cys Ile Leu Ala Thr
                725                 730                 735     
Asn Ser Glu Leu Val Gly Thr Leu Ile Gln Ser Cys Lys Asp Glu Pro
            740                 745                 750         
Phe Leu Phe Ile Gly Ala Leu Gln Lys Arg Ile Leu Asp Ile Gly Lys
        755                 760                 765             
Lys His Asp Ile Thr Glu Leu Asn Ser Asp Ala Val Asn Leu Ile Ser
    770                 775                 780                 
Gln Ala Thr Gln Glu Arg Leu Arg Gly Leu Leu Glu Lys Leu Thr Ala
785                 790                 795                 800 
Ile Ala Gln His Arg Met Thr Thr Tyr Lys Ala Ser Glu Asn Tyr Ile
                805                 810                 815     
Leu Cys Ser Asp Thr Arg Ser Gln Leu Lys Phe Leu Glu Lys Leu Asp
            820                 825                 830         
Gln Leu Glu Lys Gln Arg Lys Asp Leu Glu Glu Arg Glu Met Leu Leu
        835                 840                 845             
Lys Ala Ala Lys Ser Arg Ser Asn Lys Glu Asp Pro Glu Gln Leu Arg
    850                 855                 860                 
Leu Lys Gln Lys Ala Lys Glu Leu Gln Gln Leu Glu Leu Ala Gln Ile
865                 870                 875                 880 
Gln His Arg Asp Ala Asn Leu Thr Ala Leu Ala Ala Ile Gly Pro Arg
                885                 890                 895     
Lys Lys Arg Pro Leu Glu Ser Gly Ile Glu Gly Leu Lys Asp Asn Leu
            900                 905                 910         
Leu Ala Ser Gly Thr Ser Ser Leu Thr Ala Thr Lys Gln Leu His Arg
        915                 920                 925             
Pro Arg Ile Thr Arg Ile Cys Leu Arg Asp Leu Ile Phe Cys Met Glu
    930                 935                 940                 
Gln Glu Arg Glu Met Lys Tyr Ser Arg Ala Leu Tyr Leu Ala Leu Leu
945                 950                 955                 960 
Lys
    


<210> 8506
<211> 863
<212> PRT
<213> Homo sapiens

<400> 8506
Met Gly Asn Arg Glu Met Glu Glu Leu Ile Pro Leu Val Asn Arg Leu
 1               5                  10                  15      
Gln Asp Ala Phe Ser Ala Leu Gly Gln Ser Cys Leu Leu Glu Leu Pro
            20                  25                  30          
Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu
        35                  40                  45              
Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val
    50                  55                  60                  
Thr Arg Arg Pro Leu Val Leu Gln Leu Val Thr Ser Lys Ala Glu Tyr
65                  70                  75                  80  
Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Asp Glu
                85                  90                  95      
Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Met Asn
            100                 105                 110         
Lys Gly Ile Ser Ser Ile Pro Ile Asn Leu Arg Val Tyr Ser Pro His
        115                 120                 125             
Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro
    130                 135                 140                 
Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Glu Met Ile
145                 150                 155                 160 
Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val Thr Pro
                165                 170                 175     
Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu
            180                 185                 190         
Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp
        195                 200                 205             
Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu
    210                 215                 220                 
Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser Gln Lys
225                 230                 235                 240 
Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala Glu Arg
                245                 250                 255     
Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp Arg Met
            260                 265                 270         
Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His
        275                 280                 285             
Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly Gln Leu
    290                 295                 300                 
Leu Ser Ile Glu His Glu Val Glu Ala Tyr Lys Asn Phe Lys Pro Glu
305                 310                 315                 320 
Asp Pro Ser Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe
                325                 330                 335     
Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp
            340                 345                 350         
Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe His Glu
        355                 360                 365             
Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys Glu Leu
    370                 375                 380                 
Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr
385                 390                 395                 400 
Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Thr Val Lys Lys Gln
                405                 410                 415     
Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu Val Ile
            420                 425                 430         
Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Lys Leu Ala Asn
        435                 440                 445             
Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn His Ile
    450                 455                 460                 
Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu Ile Asp
465                 470                 475                 480 
Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe
                485                 490                 495     
Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Thr Thr Val
            500                 505                 510         
Gly Asn Gln Val Ile Arg Lys Gly Trp Leu Thr Ile Ser Asn Ile Gly
        515                 520                 525             
Ile Met Lys Gly Gly Ser Lys Gly Tyr Trp Phe Val Leu Thr Ala Glu
    530                 535                 540                 
Ser Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met
545                 550                 555                 560 
Leu Pro Leu Asp Asn Leu Lys Val Arg Asp Val Glu Lys Ser Phe Met
                565                 570                 575     
Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu Gln Arg Asn Val
            580                 585                 590         
Tyr Lys Asp Tyr Arg Phe Leu Glu Leu Ala Cys Asp Ser Gln Glu Asp
        595                 600                 605             
Val Asp Ser Trp Lys Ala Ser Leu Leu Arg Ala Gly Val Tyr Pro Asp
    610                 615                 620                 
Lys Ser Val Gly Asn Asn Lys Ala Glu Asn Asp Glu Asn Gly Gln Ala
625                 630                 635                 640 
Glu Asn Phe Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile
                645                 650                 655     
Arg Asn Leu Val Asp Ser Tyr Met Ser Ile Ile Asn Lys Cys Ile Arg
            660                 665                 670         
Asp Leu Ile Pro Lys Thr Ile Met His Leu Met Ile Asn Asn Val Lys
        675                 680                 685             
Asp Phe Ile Asn Ser Glu Leu Leu Ala Gln Leu Tyr Ser Ser Glu Asp
    690                 695                 700                 
Gln Asn Thr Leu Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp
705                 710                 715                 720 
Glu Met Leu Arg Met Tyr Gln Ala Leu Lys Glu Ala Leu Gly Ile Ile
                725                 730                 735     
Gly Asp Ile Ser Thr Ala Thr Val Ser Thr Pro Ala Pro Pro Pro Val
            740                 745                 750         
Asp Asp Ser Trp Ile Gln His Ser Arg Arg Ser Pro Pro Pro Ser Pro
        755                 760                 765             
Thr Thr Gln Arg Arg Pro Thr Leu Ser Ala Pro Leu Ala Arg Pro Thr
    770                 775                 780                 
Ser Gly Arg Gly Pro Ala Pro Ala Ile Pro Ser Pro Gly Pro His Ser
785                 790                 795                 800 
Gly Ala Pro Pro Val Pro Phe Arg Pro Gly Pro Leu Pro Pro Phe Pro
                805                 810                 815     
Ser Ser Ser Asp Ser Phe Gly Ala Pro Pro Gln Val Pro Ser Arg Pro
            820                 825                 830         
Thr Arg Ala Pro Pro Arg Val Pro Ser Arg Arg Pro Pro Pro Ser Pro
        835                 840                 845             
Thr Arg Pro Thr Ile Ile Arg Pro Leu Glu Ser Ser Leu Leu Asp
    850                 855                 860             


<210> 8507
<211> 235
<212> PRT
<213> Homo sapiens

<400> 8507
Met Gly His Val Gln Leu Val Asp Val Cys Thr Phe Ser Thr Ala Gly
 1               5                  10                  15      
Lys Leu Leu Arg Phe Gly Phe Ser Ala Met Phe Gly Phe Gly Gly Arg
            20                  25                  30          
Thr Leu Ala Leu Ala Glu Lys Tyr Arg Trp Met Ser Pro Asn Gln Arg
        35                  40                  45              
Arg Asp Phe Ala Val Val Lys Ala Leu Ala Lys Leu Lys Ala Glu Asp
    50                  55                  60                  
Cys Glu Ile Ser Phe Leu Pro Phe Asn Ser Ser Asp Asp Val Gln Glu
65                  70                  75                  80  
Arg Arg Ala Gln Gly Ser Pro Lys Ser Asp Cys Asn Asp Gln Trp Gln
                85                  90                  95      
Met Ile Gln Gly Gln Phe Leu Asn Val Ser Ile Met Ala Ile Pro Cys
            100                 105                 110         
Leu Cys Ser Val Ala Pro Arg Gly Leu Ala Pro Asn Thr Arg Leu Asn
        115                 120                 125             
Asn Gly Ser Met Ala Leu Ile Ile Ala Arg Asn Thr Ser Arg Pro Glu
    130                 135                 140                 
Phe Ile Lys His Leu Lys Arg Tyr Ala Ser Val Lys Asn Gln Phe Asn
145                 150                 155                 160 
Phe Pro Phe Val Glu Thr Tyr Thr Val Glu Glu Val Lys Val His Pro
                165                 170                 175     
Arg Asn Asn Thr Gly Gly Tyr Asn Pro Glu Glu Glu Glu Asp Glu Thr
            180                 185                 190         
Ala Ser Glu Asn Cys Phe Pro Trp Asn Val Asp Gly Asp Leu Met Glu
        195                 200                 205             
Val Ala Ser Glu Val His Ile Arg Leu His Pro Arg Leu Ile Ser Leu
    210                 215                 220                 
Tyr Gly Gly Ser Met Glu Glu Met Ile Pro Lys
225                 230                 235 


<210> 8508
<211> 536
<212> PRT
<213> Homo sapiens

<400> 8508
Met Glu Glu Pro Pro Gln Glu Ala Leu Ala Glu Pro Leu Lys His Glu
 1               5                  10                  15      
Ser Pro Ala Ala Pro Ser Ser Ala Gly His Thr Lys Gly Gln Glu Glu
            20                  25                  30          
Asp Asp Gln Lys Asn Gln Ala Glu Arg Lys Ala Asp Asn His Thr Ala
        35                  40                  45              
His Arg Ile Ala Asp Gln Thr Ala Leu Arg Val Pro Ser Gln Ala Glu
    50                  55                  60                  
Ser Ser Ile Phe Ser Gln Ala Thr Asn Gly Val Ala Glu Gln Asn Gly
65                  70                  75                  80  
His Ser Thr Pro Gly Gln Ala Gly Arg Arg Ala Ser Asn Pro Ala Asp
                85                  90                  95      
Val Ser Asp Leu Arg Ala Asp Asp Gln Val Asn Gln Thr Pro Ser Glu
            100                 105                 110         
Gln Thr Lys Gly Lys Ala Ser Ser Gln Ala Asn Asn Val Gln His Glu
        115                 120                 125             
Gln Ser Asp Gly Gln Val Ser Gly Leu Thr Glu Glu Arg Thr Ala Glu
    130                 135                 140                 
Gln Thr Glu Arg Arg Leu Pro Thr Gln Ala Glu Arg Arg Thr Ser Gly
145                 150                 155                 160 
Gln Ile Asp Gly Arg Leu Ala Met Pro Ser Asp Gln Arg Gly Ser Arg
                165                 170                 175     
Gln Thr Asp His Arg Met Ala Gly Gln Ser Glu Arg Arg Ala Ser Glu
            180                 185                 190         
Gln Met Asp Arg Arg Met Ser Gly Glu Ala Glu Arg Arg Thr Ser Glu
        195                 200                 205             
Gln Ile Thr His Arg Leu Ser Lys Leu Ser Glu Arg Arg Pro Ser Val
    210                 215                 220                 
Gln Ile Asp Ser Gly Ser Ser Val Pro Ser Asp Gln Ser Pro Ser Val
225                 230                 235                 240 
Gln Ile Asp Ser Gly Ser Ser Val Pro Ser Asp Gln Arg Pro Ser Val
                245                 250                 255     
Gln Ile Asp Arg Arg Met Ser Gly Lys Val Arg Arg Arg Ser Ser Glu
            260                 265                 270         
Lys Thr Asp Tyr Arg Leu Ala Gly Leu Ala Asp Pro Gly Thr Ser Glu
        275                 280                 285             
Gln Thr Asp Leu Arg Leu Tyr Gly Leu Val Asp His Lys Thr Ser Val
    290                 295                 300                 
Lys Thr His His Gln Val Tyr Gly Gln Ala Thr Glu Leu Ala Glu His
305                 310                 315                 320 
Gln Ala Ile Asp Gln Ala His Ser Asn Ala Asp Gln Pro Pro Val Asp
                325                 330                 335     
Asn Ala His Tyr Thr Glu Ser Asp Gln Thr Asp His Leu Ala Asp Arg
            340                 345                 350         
Gln Ala Asn His Lys Asp Gln Leu Ser Tyr Tyr Glu Thr Arg Gly Gln
        355                 360                 365             
Ser Glu Asp Arg Ile Phe Pro Gln Leu Gly Asn Ser Lys Glu Asp Lys
    370                 375                 380                 
Glu Ala Asp Tyr Arg Val Gln Pro Cys Lys Phe Glu Asp Ser Gln Val
385                 390                 395                 400 
Asp Leu Asn Ser Lys Pro Ser Val Glu Met Glu Thr Gln Asn Ala Thr
                405                 410                 415     
Thr Ile Pro Pro Tyr Asn Pro Val Asp Ala Arg Phe Thr Ser Asn Phe
            420                 425                 430         
Gln Ala Lys Asp Gln Ala Leu Phe Pro Arg Leu Pro Ser Ile Leu Ser
        435                 440                 445             
Lys Leu Asn Tyr Thr Ser Ser Gln Glu Lys Thr Gln Ala Ile Val Thr
    450                 455                 460                 
Lys Ser Asp Glu Phe Ser Glu Ile Asp Gln Gly Lys Gly Tyr His Ile
465                 470                 475                 480 
Arg Asn Gln Thr Tyr Arg Arg Phe Pro Ser Ile Val Tyr Glu Asp Pro
                485                 490                 495     
Tyr Gln Val Ser Leu Gln Tyr Met Glu Lys His His Ile Leu Gln Ile
            500                 505                 510         
Phe Gln Gln Ile Thr Glu Asn Leu Val Tyr Glu Lys Pro Glu Asp Pro
        515                 520                 525             
Leu Asn Phe Met Leu Cys Gln Val
    530                 535     


<210> 8509
<211> 799
<212> PRT
<213> Homo sapiens

<400> 8509
Met Gln Gly Glu Asp Ala Arg Tyr Leu Lys Arg Lys Val Lys Gly Gly
 1               5                  10                  15      
Asn Ile Asp Val His Pro Ser Glu Lys Ala Leu Ile Val His Tyr Glu
            20                  25                  30          
Val Glu Ala Thr Ile Leu Gly Glu Met Gly Asp Pro Met Leu Gly Glu
        35                  40                  45              
Arg Lys Glu Cys Gln Lys Ile Ile Arg Leu Lys Ser Leu Asn Ala Asn
    50                  55                  60                  
Thr Asp Ile Thr Ser Leu Ala Arg Lys Val Val Glu Glu Cys Lys Leu
65                  70                  75                  80  
Ile His Pro Ser Lys Leu Asn Glu Val Glu Gln Leu Leu Tyr Tyr Leu
                85                  90                  95      
Gln Asn Arg Arg Asp Ser Leu Ser Gly Lys Glu Lys Lys Glu Lys Ser
            100                 105                 110         
Ser Lys Pro Lys Asp Pro Pro Pro Phe Glu Gly Met Glu Ile Asp Glu
        115                 120                 125             
Val Ala Asn Ile Asn Asp Met Asp Glu Tyr Ile Glu Leu Leu Tyr Glu
    130                 135                 140                 
Asp Ile Pro Asp Lys Val Arg Gly Ser Ala Leu Ile Leu Gln Leu Ala
145                 150                 155                 160 
Arg Asn Pro Asp Asn Leu Glu Glu Leu Leu Leu Asn Glu Thr Ala Leu
                165                 170                 175     
Gly Ala Leu Ala Arg Val Leu Arg Glu Asp Trp Lys Gln Ser Val Glu
            180                 185                 190         
Leu Ala Thr Asn Ile Ile Tyr Ile Phe Phe Cys Phe Ser Ser Phe Ser
        195                 200                 205             
Gln Phe His Gly Leu Ile Thr His Tyr Lys Ile Gly Ala Leu Cys Met
    210                 215                 220                 
Asn Ile Ile Asp His Glu Leu Lys Arg His Glu Leu Trp Gln Glu Glu
225                 230                 235                 240 
Leu Ser Lys Lys Lys Lys Ala Asp Ile Leu Leu Asp Cys Leu Leu Asp
                245                 250                 255     
Glu Asp Pro Glu Asn Gln Thr Leu Arg Lys Asp Tyr Glu Lys Thr Phe
            260                 265                 270         
Lys Lys Tyr Gln Gly Leu Val Val Lys Gln Glu Gln Leu Leu Arg Val
        275                 280                 285             
Ala Leu Tyr Leu Leu Leu Asn Leu Ala Glu Asp Thr Arg Thr Glu Leu
    290                 295                 300                 
Lys Met Arg Asn Lys Asn Ile Val His Met Leu Val Lys Ala Leu Asp
305                 310                 315                 320 
Arg Asp Asn Phe Glu Leu Leu Ile Leu Val Val Ser Phe Leu Lys Lys
                325                 330                 335     
Leu Ser Ile Phe Met Glu Asn Lys Asn Asp Met Val Glu Met Asp Ile
            340                 345                 350         
Val Glu Lys Leu Val Lys Met Ile Pro Cys Glu His Glu Asp Leu Leu
        355                 360                 365             
Asn Ile Thr Leu Arg Leu Leu Leu Asn Leu Ser Phe Asp Thr Gly Leu
    370                 375                 380                 
Arg Asn Lys Met Val Gln Val Gly Leu Leu Pro Lys Leu Thr Ala Leu
385                 390                 395                 400 
Leu Gly Asn Asp Asn Tyr Lys Gln Ile Ala Met Cys Val Leu Tyr His
                405                 410                 415     
Ile Ser Met Asp Asp Arg Phe Lys Ser Met Phe Ala Tyr Thr Asp Cys
            420                 425                 430         
Ile Pro Gln Leu Met Lys Met Leu Phe Glu Cys Ser Asp Glu Arg Ile
        435                 440                 445             
Asp Leu Glu Leu Ile Ser Phe Cys Ile Asn Leu Ala Ala Asn Lys Arg
    450                 455                 460                 
Asn Val Gln Leu Ile Cys Glu Gly Asn Gly Leu Lys Met Leu Met Lys
465                 470                 475                 480 
Arg Ala Leu Lys Phe Lys Asp Pro Leu Leu Met Lys Met Ile Arg Asn
                485                 490                 495     
Ile Ser Gln His Asp Gly Pro Thr Lys Asn Leu Phe Ile Asp Tyr Val
            500                 505                 510         
Gly Asp Leu Ala Ala Gln Ile Ser Asn Asp Glu Glu Glu Glu Phe Val
        515                 520                 525             
Ile Glu Cys Leu Gly Thr Leu Ala Asn Leu Thr Ile Pro Asp Leu Asp
    530                 535                 540                 
Trp Glu Leu Val Leu Lys Glu Tyr Lys Leu Val Pro Tyr Leu Lys Asp
545                 550                 555                 560 
Lys Leu Lys Pro Gly Ala Ala Glu Asp Asp Leu Val Leu Glu Val Val
                565                 570                 575     
Ile Met Ile Gly Thr Val Ser Met Asp Asp Ser Cys Ala Ala Leu Leu
            580                 585                 590         
Ala Lys Ser Gly Ile Ile Pro Ala Leu Ile Glu Leu Leu Asn Ala Gln
        595                 600                 605             
Gln Glu Asp Asp Glu Phe Val Cys Gln Ile Ile Tyr Val Phe Tyr Gln
    610                 615                 620                 
Met Val Phe His Gln Ala Thr Arg Asp Val Ile Ile Lys Glu Thr Gln
625                 630                 635                 640 
Ala Pro Ala Tyr Leu Ile Asp Leu Met His Asp Lys Asn Asn Glu Ile
                645                 650                 655     
Arg Lys Val Cys Asp Asn Thr Leu Asp Ile Ile Ala Glu Tyr Asp Glu
            660                 665                 670         
Glu Trp Ala Lys Lys Ile Gln Ser Glu Lys Phe Arg Trp His Asn Ser
        675                 680                 685             
Gln Trp Leu Glu Met Val Glu Ser Arg Gln Met Asp Glu Ser Glu Gln
    690                 695                 700                 
Tyr Leu Tyr Gly Asp Asp Arg Ile Glu Pro Tyr Ile His Glu Gly Asp
705                 710                 715                 720 
Ile Leu Glu Arg Pro Asp Leu Phe Tyr Asn Ser Asp Gly Leu Ile Ala
                725                 730                 735     
Ser Glu Gly Ala Ile Ser Pro Asp Phe Phe Asn Asp Tyr His Leu Gln
            740                 745                 750         
Asn Gly Asp Val Val Gly Gln His Ser Phe Pro Gly Ser Leu Gly Met
        755                 760                 765             
Asp Gly Phe Gly Gln Pro Val Gly Ile Leu Gly Arg Pro Ala Thr Ala
    770                 775                 780                 
Tyr Gly Phe Arg Pro Asp Glu Pro Tyr Tyr Tyr Gly Tyr Gly Ser
785                 790                 795                 


<210> 8510
<211> 1227
<212> PRT
<213> Homo sapiens

<400> 8510
Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser
 1               5                  10                  15      
Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg
            20                  25                  30          
Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser
        35                  40                  45              
Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu
    50                  55                  60                  
Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys
65                  70                  75                  80  
Asp Phe Leu Thr Asp Arg Thr Asn Gln Ser His Leu Val Gly Val Pro
                85                  90                  95      
Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile Asp Glu His Phe
            100                 105                 110         
Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Thr
        115                 120                 125             
Thr Thr Ser Thr Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly
    130                 135                 140                 
Thr Met Gly Trp Gln Lys Ala Gly His Pro Pro Ser Asp Gly Gln Gln
145                 150                 155                 160 
Arg Ala Thr Gln Gln Gly Ser Leu Arg Thr Leu Leu Gly Asp Gly Val
                165                 170                 175     
Gly Arg Gln Gln Pro Arg Ala Lys Gln Val Cys Asn Val Glu Val Gly
            180                 185                 190         
Leu Gln Thr Gln Glu Arg Pro Pro Ala Met Ala Ala Lys His Ser Ser
        195                 200                 205             
Ser Gly His Cys Val Gln Asn Phe Pro Pro Ser Leu Ala Ser Lys Pro
    210                 215                 220                 
Ser Leu Val Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met Asp Gly
225                 230                 235                 240 
Gln Asp Gln Ala Pro Asp Glu Ser Pro Lys Leu Lys Ser Ser Ser Glu
                245                 250                 255     
Thr Ser Val His Cys Thr Ser Tyr Arg Gly Val Pro Ala Ser Lys Pro
            260                 265                 270         
Glu Pro Ala Arg Ala Lys Ala Lys Leu Ser Lys Phe Ser Ile Pro Lys
        275                 280                 285             
Gln Gly Glu Glu Ser Arg Ser Gly Glu Thr Asn Ser Cys Val Glu Glu
    290                 295                 300                 
Ile Ile Arg Glu Met Thr Trp Leu Pro Pro Leu Ser Ala Ile Gln Ala
305                 310                 315                 320 
Pro Gly Lys Val Glu Pro Thr Lys Phe Pro Phe Pro Asn Lys Asp Ser
                325                 330                 335     
Gln Leu Val Ser Ser Gly His Asn Asn Pro Lys Lys Gly Asp Ala Glu
            340                 345                 350         
Pro Glu Ser Pro Asp Asn Gly Thr Ser Asn Thr Ser Met Leu Glu Asp
        355                 360                 365             
Asp Leu Lys Leu Ser Ser Asp Glu Glu Glu Asn Glu Gln Gln Ala Ala
    370                 375                 380                 
Gln Arg Thr Ala Leu Arg Ala Leu Ser Asp Ser Ala Val Val Gln Gln
385                 390                 395                 400 
Pro Asn Cys Arg Thr Ser Val Pro Ser Ser Lys Gly Ser Ser Ser Ser
                405                 410                 415     
Ser Ser Ser Gly Thr Ser Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser
            420                 425                 430         
Gly Ser Asp Ser Glu Thr Glu Ser Ser Ser Ser Glu Ser Glu Gly Ser
        435                 440                 445             
Lys Pro Pro His Phe Ser Ser Pro Glu Ala Glu Pro Ala Ser Ser Asn
    450                 455                 460                 
Lys Trp Gln Leu Asp Lys Trp Leu Asn Lys Val Asn Pro His Lys Pro
465                 470                 475                 480 
Pro Ile Leu Ile Gln Asn Glu Ser His Gly Ser Glu Ser Asn Gln Tyr
                485                 490                 495     
Tyr Asn Pro Val Lys Glu Asp Val Gln Asp Cys Gly Lys Val Pro Asp
            500                 505                 510         
Val Cys Gln Pro Ser Leu Arg Glu Lys Glu Ile Lys Ser Thr Cys Lys
        515                 520                 525             
Glu Glu Gln Arg Pro Arg Thr Ala Asn Lys Ala Pro Gly Ser Lys Gly
    530                 535                 540                 
Val Lys Gln Lys Ser Pro Pro Ala Ala Val Ala Val Ala Val Ser Ala
545                 550                 555                 560 
Ala Ala Pro Pro Pro Ala Val Pro Cys Ala Pro Ala Glu Asn Ala Pro
                565                 570                 575     
Ala Pro Ala Arg Arg Ser Ala Gly Lys Lys Pro Thr Arg Arg Thr Glu
            580                 585                 590         
Arg Thr Ser Ala Gly Asp Gly Ala Asn Cys His Arg Pro Glu Glu Pro
        595                 600                 605             
Ala Ala Ala Asp Ala Leu Gly Thr Ser Val Val Val Pro Pro Glu Pro
    610                 615                 620                 
Thr Lys Thr Arg Pro Cys Gly Asn Asn Arg Ala Ser His Arg Lys Glu
625                 630                 635                 640 
Leu Arg Ser Ser Val Thr Cys Glu Lys Arg Arg Thr Arg Gly Leu Ser
                645                 650                 655     
Arg Ile Val Pro Lys Ser Lys Glu Phe Ile Glu Thr Glu Ser Ser Ser
            660                 665                 670         
Ser Ser Ser Ser Ser Asp Ser Asp Leu Glu Ser Glu Gln Glu Glu Tyr
        675                 680                 685             
Pro Leu Ser Lys Ala Gln Thr Val Ala Ala Ser Ala Ser Ser Gly Asn
    690                 695                 700                 
Asp Gln Arg Leu Lys Glu Ala Ala Ala Asn Gly Gly Ser Gly Pro Arg
705                 710                 715                 720 
Ala Pro Val Gly Ser Ile Asn Ala Arg Thr Thr Ser Asp Ile Ala Lys
                725                 730                 735     
Glu Leu Glu Glu Gln Phe Tyr Thr Leu Val Pro Phe Gly Arg Asn Glu
            740                 745                 750         
Leu Leu Ser Pro Leu Lys Asp Ser Asp Glu Ile Arg Ser Leu Trp Val
        755                 760                 765             
Lys Ile Asp Leu Thr Leu Leu Ser Arg Ile Pro Glu His Leu Pro Gln
    770                 775                 780                 
Glu Pro Gly Val Leu Ser Ala Pro Ala Thr Lys Asp Ser Glu Ser Ala
785                 790                 795                 800 
Pro Pro Ser His Thr Ser Asp Thr Pro Ala Glu Lys Ala Leu Pro Lys
                805                 810                 815     
Ser Lys Arg Lys Arg Lys Cys Asp Asn Glu Asp Asp Tyr Arg Glu Ile
            820                 825                 830         
Lys Lys Ser Gln Gly Glu Lys Asp Ser Ser Ser Arg Leu Ala Thr Ser
        835                 840                 845             
Thr Ser Asn Thr Leu Ser Ala Asn His Cys Asn Met Asn Ile Asn Ser
    850                 855                 860                 
Val Ala Ile Pro Ile Asn Lys Asn Glu Lys Met Leu Arg Ser Pro Ile
865                 870                 875                 880 
Ser Pro Leu Ser Asp Ala Ser Lys His Lys Tyr Thr Ser Glu Asp Leu
                885                 890                 895     
Thr Ser Ser Ser Arg Pro Asn Gly Asn Ser Leu Phe Thr Ser Ala Ser
            900                 905                 910         
Ser Ser Lys Lys Pro Lys Ala Asp Ser Gln Leu Gln Pro His Gly Gly
        915                 920                 925             
Asp Leu Thr Lys Ala Ala His Asn Asn Ser Glu Asn Ile Pro Leu His
    930                 935                 940                 
Lys Ser Arg Pro Gln Thr Lys Pro Trp Ser Pro Gly Ser Asn Gly His
945                 950                 955                 960 
Arg Asp Cys Lys Arg Gln Lys Leu Val Phe Asp Asp Met Pro Arg Ser
                965                 970                 975     
Ala Asp Tyr Phe Met Gln Glu Ala Lys Arg Met Lys His Lys Ala Asp
            980                 985                 990         
Ala Met Val Glu Lys Phe Gly Lys Ala Leu Asn Tyr Ala Glu Ala Ala
        995                 1000                1005            
Leu Ser Phe Ile Glu Cys Gly Asn Ala Met Glu Gln Gly Pro Met Glu
    1010                1015                1020                
Ser Lys Ser Pro Tyr Tyr Leu Met Tyr Ser Glu Thr Val Glu Leu Ile
1025                1030                1035                1040
Arg Tyr Ala Met Arg Leu Lys Thr His Ser Gly Pro Asn Ala Thr Pro
                1045                1050                1055    
Glu Asp Lys Gln Leu Ala Ala Leu Cys Tyr Arg Cys Leu Ala Leu Leu
            1060                1065                1070        
Tyr Trp Arg Met Phe Arg Leu Lys Arg Asp His Ala Val Lys Tyr Ser
        1075                1080                1085            
Lys Ala Leu Ile Asp Tyr Phe Lys Asn Ser Ser Lys Ala Ala Gln Ala
    1090                1095                1100                
Pro Ser Pro Trp Gly Ala Ser Gly Lys Ser Thr Gly Thr Pro Ser Pro
1105                1110                1115                1120
Ile Ser Pro Asn Pro Phe Pro Gly Ser Ser Val Gly Ser Gln Gly Ser
                1125                1130                1135    
Leu Ser Asn Ala Ser Ala Leu Ser Pro Ser Thr Ile Val Ser Ile Pro
            1140                1145                1150        
Gln Arg Ile His Gln Met Ala Ala Asn His Val Ser Ile Thr Asn Ser
        1155                1160                1165            
Ile Leu His Ser Tyr Asp Tyr Trp Glu Met Ala Asp Asn Leu Ala Lys
    1170                1175                1180                
Glu Asn Arg Glu Phe Phe Asn Asp Leu Asp Leu Leu Met Gly Pro Val
1185                1190                1195                1200
Thr Leu His Ser Ser Met Glu His Leu Val Gln Tyr Ser Gln Gln Gly
                1205                1210                1215    
Leu His Trp Leu Arg Asn Ser Ala His Leu Ser
            1220                1225        


<210> 8511
<211> 643
<212> PRT
<213> Homo sapiens

<400> 8511
Met Cys Gly Ile Cys Cys Ser Val Asn Phe Ser Ala Glu His Phe Ser
 1               5                  10                  15      
Gln Asp Leu Lys Glu Asp Leu Leu Tyr Asn Leu Lys Gln Arg Gly Pro
            20                  25                  30          
Asn Ser Ser Lys Gln Leu Leu Lys Ser Asp Val Asn Tyr Gln Cys Leu
        35                  40                  45              
Phe Ser Ala His Val Leu His Leu Arg Gly Val Leu Thr Thr Gln Pro
    50                  55                  60                  
Val Glu Asp Glu Arg Gly Asn Val Phe Leu Trp Asn Gly Glu Ile Phe
65                  70                  75                  80  
Ser Gly Ile Lys Val Glu Ala Glu Glu Asn Asp Thr Gln Ile Leu Phe
                85                  90                  95      
Asn Tyr Leu Ser Ser Cys Lys Asn Glu Ser Glu Ile Leu Ser Leu Phe
            100                 105                 110         
Ser Glu Val Gln Gly Pro Trp Ser Phe Ile Tyr Tyr Gln Ala Ser Ser
        115                 120                 125             
His Tyr Leu Trp Phe Gly Arg Asp Phe Phe Gly Arg Arg Ser Leu Leu
    130                 135                 140                 
Trp His Phe Ser Asn Leu Gly Lys Ser Phe Cys Leu Ser Ser Val Gly
145                 150                 155                 160 
Thr Gln Thr Ser Gly Leu Ala Asn Gln Trp Gln Glu Val Pro Ala Ser
                165                 170                 175     
Gly Leu Phe Arg Ile Asp Leu Lys Ser Thr Val Ile Ser Arg Cys Ile
            180                 185                 190         
Ile Leu Gln Leu Tyr Pro Trp Lys Tyr Ile Ser Arg Glu Asn Ile Ile
        195                 200                 205             
Glu Glu Asn Val Asn Ser Leu Ser Gln Ile Ser Ala Asp Leu Pro Ala
    210                 215                 220                 
Phe Val Ser Val Val Ala Asn Glu Ala Lys Leu Tyr Leu Glu Lys Pro
225                 230                 235                 240 
Val Val Pro Leu Asn Met Met Leu Pro Gln Ala Ala Leu Glu Thr His
                245                 250                 255     
Cys Ser Asn Ile Ser Asn Val Pro Pro Thr Arg Glu Ile Leu Gln Val
            260                 265                 270         
Phe Leu Thr Asp Val His Met Lys Glu Val Ile Gln Gln Phe Ile Asp
        275                 280                 285             
Val Leu Ser Val Ala Val Lys Lys Arg Val Leu Cys Leu Pro Arg Asp
    290                 295                 300                 
Glu Asn Leu Thr Ala Asn Glu Val Leu Lys Thr Cys Asp Arg Lys Ala
305                 310                 315                 320 
Asn Val Ala Ile Leu Phe Ser Gly Gly Ile Asp Ser Met Val Ile Ala
                325                 330                 335     
Thr Leu Ala Asp Arg His Ile Pro Leu Asp Glu Pro Ile Asp Leu Leu
            340                 345                 350         
Asn Val Ala Phe Ile Ala Glu Glu Lys Thr Met Pro Thr Thr Phe Asn
        355                 360                 365             
Arg Glu Gly Asn Lys Gln Lys Asn Lys Cys Glu Ile Pro Ser Glu Glu
    370                 375                 380                 
Phe Ser Lys Asp Val Ala Ala Ala Ala Ala Asp Ser Pro Asn Lys His
385                 390                 395                 400 
Val Ser Val Pro Asp Arg Ile Thr Gly Arg Ala Gly Leu Lys Glu Leu
                405                 410                 415     
Gln Ala Val Ser Pro Ser Arg Ile Trp Asn Phe Val Glu Ile Asn Val
            420                 425                 430         
Ser Met Glu Glu Leu Gln Lys Leu Arg Arg Thr Arg Ile Cys His Leu
        435                 440                 445             
Ile Arg Pro Leu Asp Thr Val Leu Asp Asp Ser Ile Gly Cys Ala Val
    450                 455                 460                 
Trp Phe Ala Ser Arg Gly Ile Gly Trp Leu Val Ala Gln Glu Gly Val
465                 470                 475                 480 
Lys Ser Tyr Gln Ser Asn Ala Lys Val Val Leu Thr Gly Ile Gly Ala
                485                 490                 495     
Asp Glu Gln Leu Ala Gly Tyr Ser Arg His Arg Val Arg Phe Gln Ser
            500                 505                 510         
His Gly Leu Glu Gly Leu Asn Lys Glu Ile Met Met Glu Leu Gly Arg
        515                 520                 525             
Ile Ser Ser Arg Asn Leu Gly Arg Asp Asp Arg Val Ile Gly Asp His
    530                 535                 540                 
Gly Lys Glu Ala Arg Phe Pro Phe Leu Asp Glu Asn Val Val Ser Phe
545                 550                 555                 560 
Leu Asn Ser Leu Pro Ile Trp Glu Lys Ala Asn Leu Thr Leu Pro Arg
                565                 570                 575     
Gly Ile Gly Glu Lys Leu Leu Leu Arg Leu Ala Ala Val Glu Leu Gly
            580                 585                 590         
Leu Thr Ala Ser Ala Leu Leu Pro Lys Arg Ala Met Gln Phe Gly Ser
        595                 600                 605             
Arg Ile Ala Lys Met Glu Lys Ile Asn Glu Lys Ala Ser Asp Lys Cys
    610                 615                 620                 
Gly Arg Leu Gln Ile Met Ser Leu Glu Asn Leu Ser Ile Glu Lys Glu
625                 630                 635                 640 
Thr Lys Leu
            


<210> 8512
<211> 1791
<212> PRT
<213> Homo sapiens

<400> 8512
Met Glu Thr Arg Ser Ser Lys Thr Arg Arg Ser Leu Ala Ser Arg Thr
 1               5                  10                  15      
Asn Glu Cys Gln Gly Thr Met Trp Ala Pro Thr Ser Pro Pro Ala Gly
            20                  25                  30          
Ser Ser Ser Pro Ser Gln Pro Thr Trp Lys Ser Ser Leu Tyr Ser Ser
        35                  40                  45              
Leu Ala Tyr Ser Glu Ala Phe His Tyr Ser Phe Ala Ala Arg Pro Arg
    50                  55                  60                  
Arg Leu Thr Gln Leu Ala Leu Ala Gln Arg Pro Glu Pro Gln Leu Leu
65                  70                  75                  80  
Arg Leu Arg Pro Ser Ser Leu Arg Thr Gln Asp Ile Ser His Leu Leu
                85                  90                  95      
Thr Gly Val Phe Arg Asn Leu Tyr Ser Ala Glu Val Ile Gly Asp Glu
            100                 105                 110         
Val Ser Ala Ser Leu Ile Lys Ala Arg Gly Ser Glu Asn Glu Arg His
        115                 120                 125             
Glu Glu Phe Val Asp Gln Leu Gln Gln Ile Arg Glu Leu Tyr Lys Gln
    130                 135                 140                 
Arg Leu Asp Glu Phe Glu Met Leu Glu Arg His Ile Thr Gln Ala Gln
145                 150                 155                 160 
Ala Arg Ala Ile Ala Glu Asn Glu Arg Val Met Ser Gln Ala Gly Val
                165                 170                 175     
Gln Asp Leu Glu Ser Leu Val Arg Leu Pro Pro Val Lys Ser Val Ser
            180                 185                 190         
Arg Trp Cys Ile Asp Ser Glu Leu Leu Arg Lys His His Leu Ile Ser
        195                 200                 205             
Pro Glu Asp Tyr Tyr Thr Asp Thr Val Pro Phe His Ser Ala Pro Lys
    210                 215                 220                 
Gly Ile Ser Leu Pro Gly Cys Ser Lys Leu Thr Phe Ser Cys Glu Lys
225                 230                 235                 240 
Arg Ser Val Gln Lys Lys Glu Leu Asn Lys Lys Leu Glu Asp Ser Cys
                245                 250                 255     
Arg Lys Lys Leu Ala Glu Phe Glu Asp Glu Leu Asp His Thr Val Asp
            260                 265                 270         
Ser Leu Thr Trp Asn Leu Thr Pro Lys Ala Lys Glu Arg Thr Arg Glu
        275                 280                 285             
Pro Leu Lys Lys Ala Ser Gln Pro Arg Asn Lys Asn Trp Met Asn His
    290                 295                 300                 
Leu Arg Val Pro Gln Arg Glu Leu Asp Arg Leu Leu Leu Ala Arg Met
305                 310                 315                 320 
Glu Ser Arg Asn His Phe Leu Lys Asn Pro Arg Phe Phe Pro Pro Asn
                325                 330                 335     
Thr Arg Tyr Gly Gly Lys Ser Leu Val Phe Pro Pro Lys Lys Pro Ala
            340                 345                 350         
Pro Ile Gly Glu Phe Gln Ser Thr Glu Pro Glu Gln Ser Cys Ala Asp
        355                 360                 365             
Thr Pro Val Phe Leu Ala Lys Pro Pro Ile Gly Phe Phe Thr Asp Tyr
    370                 375                 380                 
Glu Ile Gly Pro Val Tyr Glu Met Val Ile Ala Leu Gln Asn Thr Thr
385                 390                 395                 400 
Thr Thr Ser Arg Tyr Leu Arg Val Leu Pro Pro Ser Thr Pro Tyr Phe
                405                 410                 415     
Ala Leu Gly Leu Gly Met Phe Pro Gly Lys Gly Gly Met Val Ala Pro
            420                 425                 430         
Gly Met Thr Cys Gln Tyr Ile Val Gln Phe Phe Pro Asp Cys Leu Gly
        435                 440                 445             
Asp Phe Asp Asp Phe Ile Leu Val Glu Thr Gln Ser Ala His Thr Leu
    450                 455                 460                 
Leu Ile Pro Leu Gln Ala Arg Arg Pro Pro Pro Val Leu Thr Leu Ser
465                 470                 475                 480 
Pro Val Leu Asp Cys Gly Tyr Cys Leu Ile Gly Gly Val Lys Met Thr
                485                 490                 495     
Arg Phe Ile Cys Lys Asn Val Gly Phe Ser Val Gly Arg Phe Cys Ile
            500                 505                 510         
Met Pro Lys Thr Ser Trp Pro Pro Leu Ser Phe Lys Ala Ile Ala Thr
        515                 520                 525             
Val Gly Phe Val Glu Gln Pro Pro Phe Gly Ile Leu Pro Ser Val Phe
    530                 535                 540                 
Glu Leu Ala Pro Gly His Ala Ile Leu Val Glu Val Leu Phe Ser Pro
545                 550                 555                 560 
Lys Ser Leu Gly Lys Ala Glu Gln Thr Phe Ile Ile Met Cys Asp Asn
                565                 570                 575     
Cys Gln Ile Lys Glu Leu Val Thr Ile Gly Ile Gly Gln Leu Ile Ala
            580                 585                 590         
Leu Asp Leu Ile Tyr Ile Ser Gly Glu Lys Ser Gln Pro Asp Pro Gly
        595                 600                 605             
Glu Leu Thr Asp Leu Thr Ala Gln His Phe Ile Arg Phe Glu Pro Glu
    610                 615                 620                 
Asn Leu Arg Ser Thr Ala Arg Lys Gln Leu Ile Ile Arg Asn Ala Thr
625                 630                 635                 640 
His Val Glu Leu Ala Phe Tyr Trp Gln Ile Met Lys Pro Asn Leu Gln
                645                 650                 655     
Pro Leu Met Pro Gly Glu Thr Phe Ser Met Asp Ser Ile Lys Cys Tyr
            660                 665                 670         
Pro Asp Lys Glu Thr Ala Phe Ser Ile Met Pro Arg Lys Gly Val Leu
        675                 680                 685             
Ser Pro His Thr Asp His Glu Phe Ile Leu Ser Phe Ser Pro His Glu
    690                 695                 700                 
Leu Arg Asp Phe His Ser Val Leu Gln Met Val Leu Glu Glu Val Pro
705                 710                 715                 720 
Glu Pro Val Ser Ser Glu Ala Glu Ser Leu Gly His Ser Ser Tyr Ser
                725                 730                 735     
Val Asp Asp Val Ile Val Leu Glu Ile Glu Val Lys Gly Ser Val Glu
            740                 745                 750         
Pro Phe Gln Val Leu Leu Glu Pro Tyr Ala Leu Ile Ile Pro Gly Glu
        755                 760                 765             
Asn Tyr Ile Gly Ile Asn Val Lys Lys Ala Phe Lys Met Trp Asn Asn
    770                 775                 780                 
Ser Lys Ser Pro Ile Arg Tyr Leu Trp Gly Lys Ile Ser Asp Cys His
785                 790                 795                 800 
Ile Ile Glu Val Glu Pro Gly Thr Gly Val Ile Glu Pro Ser Glu Val
                805                 810                 815     
Gly Asp Phe Glu Leu Asn Phe Thr Gly Gly Val Pro Gly Pro Thr Ser
            820                 825                 830         
Gln Asp Leu Leu Cys Glu Ile Glu Asp Ser Pro Ser Pro Val Val Leu
        835                 840                 845             
His Ile Glu Ala Val Phe Lys Gly Pro Ala Leu Ile Ile Asn Val Ser
    850                 855                 860                 
Ala Leu Gln Phe Gly Leu Leu Arg Leu Gly Gln Lys Ala Thr Asn Ser
865                 870                 875                 880 
Ile Gln Ile Arg Asn Val Ser Gln Leu Pro Ala Thr Trp Arg Met Lys
                885                 890                 895     
Glu Ser Pro Val Ser Leu Gln Glu Arg Pro Glu Asp Val Ser Pro Phe
            900                 905                 910         
Asp Ile Glu Pro Ser Ser Gly Gln Leu His Ser Leu Gly Glu Cys Arg
        915                 920                 925             
Val Asp Ile Thr Leu Glu Ala Leu His Cys Gln His Leu Glu Thr Val
    930                 935                 940                 
Leu Glu Leu Glu Val Glu Asn Gly Ala Trp Ser Tyr Leu Pro Val Tyr
945                 950                 955                 960 
Ala Glu Val Gln Lys Pro His Val Tyr Leu Gln Ser Ser Gln Val Glu
                965                 970                 975     
Val Arg Asn Leu Tyr Leu Gly Val Pro Thr Lys Thr Thr Ile Thr Leu
            980                 985                 990         
Ile Asn Gly Thr Leu Leu Pro Thr Gln Phe His Trp Gly Lys Leu Leu
        995                 1000                1005            
Gly His Gln Ala Glu Phe Cys Met Val Thr Val Ser Pro Lys His Gly
    1010                1015                1020                
Leu Leu Gly Pro Ser Glu Glu Cys Gln Leu Lys Leu Glu Leu Thr Ala
1025                1030                1035                1040
His Thr Gln Glu Glu Leu Thr His Leu Ala Leu Pro Cys His Val Ser
                1045                1050                1055    
Gly Met Lys Lys Pro Leu Val Leu Gly Ile Ser Gly Lys Pro Gln Gly
            1060                1065                1070        
Leu Gln Val Ala Ile Thr Ile Ser Lys Glu Ser Ser Asp Cys Ser Thr
        1075                1080                1085            
Glu Gln Trp Pro Gly His Pro Lys Glu Leu Arg Leu Asp Phe Gly Ser
    1090                1095                1100                
Ala Val Pro Leu Arg Thr Arg Val Thr Arg Gln Leu Ile Leu Thr Asn
1105                1110                1115                1120
Arg Ser Pro Ile Arg Thr Arg Phe Ser Leu Lys Phe Glu Tyr Phe Gly
                1125                1130                1135    
Ser Pro Gln Asn Ser Leu Ser Lys Lys Thr Ser Leu Pro Asn Met Pro
            1140                1145                1150        
Pro Ala Leu Leu Lys Thr Val Arg Met Gln Glu His Leu Ala Lys Arg
        1155                1160                1165            
Glu Gln Leu Asp Phe Met Glu Ser Met Leu Ser His Gly Lys Gly Ala
    1170                1175                1180                
Ala Phe Phe Pro His Phe Ser Gln Gly Met Leu Gly Pro Tyr Gln Gln
1185                1190                1195                1200
Leu Cys Ile Asp Ile Thr Gly Cys Ala Asn Met Trp Gly Glu Tyr Trp
                1205                1210                1215    
Asp Asn Leu Ile Cys Thr Val Gly Asp Leu Leu Pro Glu Val Ile Pro
            1220                1225                1230        
Val His Met Ala Ala Val Gly Cys Pro Ile Ser Ser Leu Arg Thr Thr
        1235                1240                1245            
Ser Tyr Thr Ile Asp Gln Ala Gln Lys Glu Pro Ala Met Arg Phe Gly
    1250                1255                1260                
Thr Gln Val Ser Gly Gly Asp Thr Val Thr Arg Thr Leu Arg Leu Asn
1265                1270                1275                1280
Asn Ser Ser Pro Cys Asp Ile Arg Leu Asp Trp Glu Thr Tyr Val Pro
                1285                1290                1295    
Glu Asp Lys Glu Asp Arg Leu Val Glu Leu Leu Val Phe Tyr Gly Pro
            1300                1305                1310        
Pro Phe Pro Leu Arg Asp Gln Ala Gly Asn Glu Leu Val Cys Pro Asp
        1315                1320                1325            
Thr Pro Glu Gly Gly Cys Leu Leu Trp Ser Pro Gly Pro Ser Ser Ser
    1330                1335                1340                
Ser Glu Phe Ser His Glu Thr Asp Ser Ser Val Glu Gly Ser Ser Ser
1345                1350                1355                1360
Ala Ser Asn Arg Val Ala Gln Lys Leu Ile Ser Val Ile Leu Gln Ala
                1365                1370                1375    
His Glu Gly Val Pro Ser Gly His Leu Tyr Cys Ile Ser Pro Lys Gln
            1380                1385                1390        
Val Val Val Pro Ala Gly Gly Ser Ser Thr Ile Tyr Ile Ser Phe Thr
        1395                1400                1405            
Pro Met Val Leu Ser Pro Glu Ile Leu His Lys Val Glu Cys Thr Gly
    1410                1415                1420                
Tyr Ala Leu Gly Phe Met Ser Leu Asp Ser Lys Val Glu Arg Glu Ile
1425                1430                1435                1440
Pro Gly Lys Arg His Arg Leu Gln Asp Phe Ala Val Gly Pro Leu Lys
                1445                1450                1455    
Leu Asp Leu His Ser Tyr Val Arg Pro Ala Gln Leu Ser Val Glu Leu
            1460                1465                1470        
Asp Tyr Gly Gly Ser Met Glu Phe Gln Cys Gln Ala Ser Asp Leu Ile
        1475                1480                1485            
Pro Glu Gln Pro Cys Ser Gly Val Leu Ser Glu Leu Val Thr Thr His
    1490                1495                1500                
His Leu Lys Leu Thr Asn Thr Thr Glu Ile Pro His Tyr Phe Arg Leu
1505                1510                1515                1520
Met Val Ser Arg Pro Phe Ser Val Ser Gln Asp Gly Ala Ser Gln Asp
                1525                1530                1535    
His Arg Ala Pro Gly Pro Gly Gln Lys Gln Glu Cys Glu Glu Glu Thr
            1540                1545                1550        
Ala Ser Ala Asp Lys Gln Leu Val Leu Gln Ala Gln Glu Asn Met Leu
        1555                1560                1565            
Val Asn Val Ser Phe Ser Leu Ser Leu Glu Leu Leu Ser Tyr Gln Lys
    1570                1575                1580                
Leu Pro Ala Asp Gln Thr Leu Pro Gly Val Asp Ile Gln Gln Ser Ala
1585                1590                1595                1600
Ser Gly Glu Arg Glu Met Val Phe Thr Gln Asn Leu Leu Leu Glu Tyr
                1605                1610                1615    
Thr Asn Gln Thr Thr Gln Ala Arg Pro Arg Pro Thr Tyr Met Trp Arg
            1620                1625                1630        
Arg Val Glu Val Val Pro Leu Arg Ala Val Val Ala Val Pro Glu Leu
        1635                1640                1645            
Gln Leu Ser Thr Ser Trp Val Asp Phe Gly Thr Cys Phe Val Ser Gln
    1650                1655                1660                
Gln Arg Val Arg Glu Val Tyr Leu Met Asn Leu Ser Gly Cys Arg Ser
1665                1670                1675                1680
Tyr Trp Thr Met Leu Met Gly Val Val Ser Cys Thr Ser Pro Arg Trp
                1685                1690                1695    
Trp Trp Lys Val Cys Ser Val Arg Ser Pro Ala Pro Cys Gly Ser Gly
            1700                1705                1710        
Ala Lys Ala Pro Met Met Arg Asp Thr Cys Cys Leu Thr Ser Pro Glu
        1715                1720                1725            
Ala Pro Pro Gln Pro Ser Ala Pro Gly Pro Ser Trp Arg Lys Asn Ile
    1730                1735                1740                
Ala Gln Gly Leu Gly Ala Ala Leu Gln His Lys Asp Thr Asp Leu Gly
1745                1750                1755                1760
Thr Trp Gly Pro Leu Gly Ser Ser Trp Asn Gly Arg Thr Pro Phe His
                1765                1770                1775    
Asn Gly Leu Ser Leu Gly Pro His Asp Met Ser Ser Glu Leu Thr
            1780                1785                1790    


<210> 8513
<211> 1768
<212> PRT
<213> Homo sapiens

<400> 8513
Met Glu Thr Arg Ser Ser Lys Thr Arg Arg Ser Leu Ala Ser Arg Thr
 1               5                  10                  15      
Asn Glu Cys Gln Gly Thr Met Trp Ala Pro Thr Ser Pro Pro Ala Gly
            20                  25                  30          
Ser Ser Ser Pro Ser Gln Pro Thr Trp Lys Ser Ser Leu Tyr Ser Ser
        35                  40                  45              
Leu Ala Tyr Ser Glu Ala Phe His Tyr Ser Phe Ala Ala Arg Pro Arg
    50                  55                  60                  
Arg Leu Thr Gln Leu Ala Leu Ala Gln Arg Pro Glu Pro Gln Leu Leu
65                  70                  75                  80  
Arg Leu Arg Pro Ser Ser Leu Arg Thr Gln Asp Ile Ser His Leu Leu
                85                  90                  95      
Thr Gly Val Phe Arg Asn Leu Tyr Ser Ala Glu Val Ile Gly Asp Glu
            100                 105                 110         
Val Ser Ala Ser Leu Ile Lys Ala Arg Gly Ser Glu Asn Glu Arg His
        115                 120                 125             
Glu Glu Phe Val Asp Gln Leu Gln Gln Ile Arg Glu Leu Tyr Lys Gln
    130                 135                 140                 
Arg Leu Asp Glu Phe Glu Met Leu Glu Arg His Ile Thr Gln Ala Gln
145                 150                 155                 160 
Ala Arg Ala Ile Ala Glu Asn Glu Arg Val Met Ser Gln Ala Gly Val
                165                 170                 175     
Gln Asp Leu Glu Ser Leu Val Arg Leu Pro Pro Val Lys Ser Val Ser
            180                 185                 190         
Arg Trp Cys Ile Asp Ser Glu Leu Leu Arg Lys His His Leu Ile Ser
        195                 200                 205             
Pro Glu Asp Tyr Tyr Thr Asp Thr Val Pro Phe His Ser Ala Pro Lys
    210                 215                 220                 
Gly Ile Ser Leu Pro Gly Cys Ser Lys Leu Thr Phe Ser Cys Glu Lys
225                 230                 235                 240 
Arg Ser Val Gln Lys Lys Glu Leu Asn Lys Lys Leu Glu Asp Ser Cys
                245                 250                 255     
Arg Lys Lys Leu Ala Glu Phe Glu Asp Glu Leu Asp His Thr Val Asp
            260                 265                 270         
Ser Leu Thr Trp Asn Leu Thr Pro Lys Ala Lys Glu Arg Thr Arg Glu
        275                 280                 285             
Pro Leu Lys Lys Ala Ser Gln Pro Arg Asn Lys Asn Trp Met Asn His
    290                 295                 300                 
Leu Arg Val Pro Gln Arg Glu Leu Asp Arg Leu Leu Leu Ala Arg Met
305                 310                 315                 320 
Glu Ser Arg Asn His Phe Leu Lys Asn Pro Arg Phe Phe Pro Pro Asn
                325                 330                 335     
Thr Arg Tyr Gly Gly Lys Ser Leu Val Phe Pro Pro Lys Lys Pro Ala
            340                 345                 350         
Pro Ile Gly Glu Phe Gln Ser Thr Glu Pro Glu Gln Ser Cys Ala Asp
        355                 360                 365             
Thr Pro Val Phe Leu Ala Lys Pro Pro Ile Gly Phe Phe Thr Asp Tyr
    370                 375                 380                 
Glu Ile Gly Pro Val Tyr Glu Met Val Ile Ala Leu Gln Asn Thr Thr
385                 390                 395                 400 
Thr Thr Ser Arg Tyr Leu Arg Val Leu Pro Pro Ser Thr Pro Tyr Phe
                405                 410                 415     
Ala Leu Gly Leu Gly Met Phe Pro Gly Lys Gly Gly Met Val Ala Pro
            420                 425                 430         
Gly Met Thr Cys Gln Tyr Ile Val Gln Phe Phe Pro Asp Cys Leu Gly
        435                 440                 445             
Asp Phe Asp Asp Phe Ile Leu Val Glu Thr Gln Ser Ala His Thr Leu
    450                 455                 460                 
Leu Ile Pro Leu Gln Ala Arg Arg Pro Pro Pro Val Leu Thr Leu Ser
465                 470                 475                 480 
Pro Val Leu Asp Cys Gly Tyr Cys Leu Ile Gly Gly Val Lys Met Thr
                485                 490                 495     
Arg Phe Ile Cys Lys Asn Val Gly Phe Ser Val Gly Arg Phe Cys Ile
            500                 505                 510         
Met Pro Lys Thr Ser Trp Pro Pro Leu Ser Phe Lys Ala Ile Ala Thr
        515                 520                 525             
Val Gly Phe Val Glu Gln Pro Pro Phe Gly Ile Leu Pro Ser Val Phe
    530                 535                 540                 
Glu Leu Ala Pro Gly His Ala Ile Leu Val Glu Val Leu Phe Ser Pro
545                 550                 555                 560 
Lys Ser Leu Gly Lys Ala Glu Gln Thr Phe Ile Ile Met Cys Asp Asn
                565                 570                 575     
Cys Gln Ile Lys Glu Leu Val Thr Ile Gly Ile Gly Gln Leu Ile Ala
            580                 585                 590         
Leu Asp Leu Ile Tyr Ile Ser Gly Glu Lys Ser Gln Pro Asp Pro Gly
        595                 600                 605             
Glu Leu Thr Asp Leu Thr Ala Gln His Phe Ile Arg Phe Glu Pro Glu
    610                 615                 620                 
Asn Leu Arg Ser Thr Ala Arg Lys Gln Leu Ile Ile Arg Asn Ala Thr
625                 630                 635                 640 
His Val Glu Leu Ala Phe Tyr Trp Gln Ile Met Lys Pro Asn Leu Gln
                645                 650                 655     
Pro Leu Met Pro Gly Glu Thr Phe Ser Met Asp Ser Ile Lys Cys Tyr
            660                 665                 670         
Pro Asp Lys Glu Thr Ala Phe Ser Ile Met Pro Arg Lys Gly Val Leu
        675                 680                 685             
Ser Pro His Thr Asp His Glu Phe Ile Leu Ser Phe Ser Pro His Glu
    690                 695                 700                 
Leu Arg Asp Phe His Ser Val Leu Gln Met Val Leu Glu Glu Val Pro
705                 710                 715                 720 
Glu Pro Val Ser Ser Glu Ala Glu Ser Leu Gly His Ser Ser Tyr Ser
                725                 730                 735     
Val Asp Asp Val Ile Val Leu Glu Ile Glu Val Lys Gly Ser Val Glu
            740                 745                 750         
Pro Phe Gln Val Leu Leu Glu Pro Tyr Ala Leu Ile Ile Pro Gly Glu
        755                 760                 765             
Asn Tyr Ile Gly Ile Asn Val Lys Lys Ala Phe Lys Met Trp Asn Asn
    770                 775                 780                 
Ser Lys Ser Pro Ile Arg Tyr Leu Trp Gly Lys Ile Ser Asp Cys His
785                 790                 795                 800 
Ile Ile Glu Val Glu Pro Gly Thr Gly Val Ile Glu Pro Ser Glu Val
                805                 810                 815     
Gly Asp Phe Glu Leu Asn Phe Thr Gly Gly Val Pro Gly Pro Thr Ser
            820                 825                 830         
Gln Asp Leu Leu Cys Glu Ile Glu Asp Ser Pro Ser Pro Val Val Leu
        835                 840                 845             
His Ile Glu Ala Val Phe Lys Gly Pro Ala Leu Ile Ile Asn Val Ser
    850                 855                 860                 
Ala Leu Gln Phe Gly Leu Leu Arg Leu Gly Gln Lys Ala Thr Asn Ser
865                 870                 875                 880 
Ile Gln Ile Arg Asn Val Ser Gln Leu Pro Ala Thr Trp Arg Met Lys
                885                 890                 895     
Glu Ser Pro Val Ser Leu Gln Glu Arg Pro Glu Asp Val Ser Pro Phe
            900                 905                 910         
Asp Ile Glu Pro Ser Ser Gly Gln Leu His Ser Leu Gly Glu Cys Arg
        915                 920                 925             
Val Asp Ile Thr Leu Glu Ala Leu His Cys Gln His Leu Glu Thr Val
    930                 935                 940                 
Leu Glu Leu Glu Val Glu Asn Gly Ala Trp Ser Tyr Leu Pro Val Tyr
945                 950                 955                 960 
Ala Glu Val Gln Lys Pro His Val Tyr Leu Gln Ser Ser Gln Val Glu
                965                 970                 975     
Val Arg Asn Leu Tyr Leu Gly Val Pro Thr Lys Thr Thr Ile Thr Leu
            980                 985                 990         
Ile Asn Gly Thr Leu Leu Pro Thr Gln Phe His Trp Gly Lys Leu Leu
        995                 1000                1005            
Gly His Gln Ala Glu Phe Cys Met Val Thr Val Ser Pro Lys His Gly
    1010                1015                1020                
Leu Leu Gly Pro Ser Glu Glu Cys Gln Leu Lys Leu Glu Leu Thr Ala
1025                1030                1035                1040
His Thr Gln Glu Glu Leu Thr His Leu Ala Leu Pro Cys His Val Ser
                1045                1050                1055    
Gly Met Lys Lys Pro Leu Val Leu Gly Ile Ser Gly Lys Pro Gln Gly
            1060                1065                1070        
Leu Gln Val Ala Ile Thr Ile Ser Lys Glu Ser Ser Asp Cys Ser Thr
        1075                1080                1085            
Glu Gln Trp Pro Gly His Pro Lys Glu Leu Arg Leu Asp Phe Gly Ser
    1090                1095                1100                
Ala Val Pro Leu Arg Thr Arg Val Thr Arg Gln Leu Ile Leu Thr Asn
1105                1110                1115                1120
Arg Ser Pro Ile Arg Thr Arg Phe Ser Leu Lys Phe Glu Tyr Phe Gly
                1125                1130                1135    
Ser Pro Gln Asn Ser Leu Ser Lys Lys Thr Ser Leu Pro Asn Met Pro
            1140                1145                1150        
Pro Ala Leu Leu Lys Thr Val Arg Met Gln Glu His Leu Ala Lys Arg
        1155                1160                1165            
Glu Gln Leu Asp Phe Met Glu Ser Met Leu Ser His Gly Lys Gly Ala
    1170                1175                1180                
Ala Phe Phe Pro His Phe Ser Gln Gly Met Leu Gly Pro Tyr Gln Gln
1185                1190                1195                1200
Leu Cys Ile Asp Ile Thr Gly Cys Ala Asn Met Trp Gly Glu Tyr Trp
                1205                1210                1215    
Asp Asn Leu Ile Cys Thr Val Gly Asp Leu Leu Pro Glu Val Ile Pro
            1220                1225                1230        
Val His Met Ala Ala Val Gly Cys Pro Ile Ser Ser Leu Arg Thr Thr
        1235                1240                1245            
Ser Tyr Thr Ile Asp Gln Ala Gln Lys Glu Pro Ala Met Arg Phe Gly
    1250                1255                1260                
Thr Gln Val Ser Gly Gly Asp Thr Val Thr Arg Thr Leu Arg Leu Asn
1265                1270                1275                1280
Asn Ser Ser Pro Cys Asp Ile Arg Leu Asp Trp Glu Thr Tyr Val Pro
                1285                1290                1295    
Glu Asp Lys Glu Asp Arg Leu Val Glu Leu Leu Val Phe Tyr Gly Pro
            1300                1305                1310        
Pro Phe Pro Leu Arg Asp Gln Ala Gly Asn Glu Leu Val Cys Pro Asp
        1315                1320                1325            
Thr Pro Glu Gly Gly Cys Leu Leu Trp Ser Pro Gly Pro Ser Ser Ser
    1330                1335                1340                
Ser Glu Phe Ser His Glu Thr Asp Ser Ser Val Glu Gly Ser Ser Ser
1345                1350                1355                1360
Ala Ser Asn Arg Val Ala Gln Lys Leu Ile Ser Val Ile Leu Gln Ala
                1365                1370                1375    
His Glu Gly Val Pro Ser Gly His Leu Tyr Cys Ile Ser Pro Lys Gln
            1380                1385                1390        
Val Val Val Pro Ala Gly Gly Ser Ser Thr Ile Tyr Ile Ser Phe Thr
        1395                1400                1405            
Pro Met Val Leu Ser Pro Glu Ile Leu His Lys Val Glu Cys Thr Gly
    1410                1415                1420                
Tyr Ala Leu Gly Phe Met Ser Leu Asp Ser Lys Val Glu Arg Glu Ile
1425                1430                1435                1440
Pro Gly Lys Arg His Arg Leu Gln Asp Phe Ala Val Gly Pro Leu Lys
                1445                1450                1455    
Leu Asp Leu His Ser Tyr Val Arg Pro Ala Gln Leu Ser Val Glu Leu
            1460                1465                1470        
Asp Tyr Gly Gly Ser Met Glu Phe Gln Cys Gln Ala Ser Asp Leu Ile
        1475                1480                1485            
Pro Glu Gln Pro Cys Ser Gly Val Leu Ser Glu Leu Val Thr Thr His
    1490                1495                1500                
His Leu Lys Leu Thr Asn Thr Thr Glu Ile Pro His Tyr Phe Arg Leu
1505                1510                1515                1520
Met Val Ser Arg Pro Phe Ser Val Ser Gln Asp Gly Ala Ser Gln Asp
                1525                1530                1535    
His Arg Ala Pro Gly Pro Gly Gln Lys Gln Glu Cys Glu Glu Glu Thr
            1540                1545                1550        
Ala Ser Ala Asp Lys Gln Leu Val Leu Gln Ala Gln Glu Asn Met Leu
        1555                1560                1565            
Val Asn Val Ser Phe Ser Leu Ser Leu Glu Leu Leu Ser Tyr Gln Lys
    1570                1575                1580                
Leu Pro Ala Asp Gln Thr Leu Pro Gly Val Asp Ile Gln Gln Ser Ala
1585                1590                1595                1600
Ser Gly Glu Arg Glu Met Val Phe Thr Gln Asn Leu Leu Leu Glu Tyr
                1605                1610                1615    
Thr Asn Gln Thr Thr Gln Ala Arg Pro Arg Pro Thr Tyr Met Trp Arg
            1620                1625                1630        
Arg Val Glu Val Val Pro Leu Arg Ala Val Val Ala Val Pro Glu Leu
        1635                1640                1645            
Gln Leu Ser Thr Ser Trp Val Asp Phe Gly Thr Cys Phe Val Ser Gln
    1650                1655                1660                
Gln Arg Val Arg Glu Val Tyr Leu Met Asn Leu Ser Gly Cys Arg Ser
1665                1670                1675                1680
Tyr Trp Thr Met Leu Met Gly Gln Gln Glu Pro Ala Lys Ala Ala Val
                1685                1690                1695    
Ala Phe Arg Val Ser Pro Asn Ser Gly Leu Leu Glu Ala Arg Ser Ala
            1700                1705                1710        
Asn Ala Pro Pro Thr Ser Ile Ala Leu Gln Val Phe Phe Thr Ala Arg
        1715                1720                1725            
Ser Ser Glu Leu Tyr Glu Ser Thr Met Val Val Glu Gly Val Leu Gly
    1730                1735                1740                
Glu Lys Ser Cys Thr Leu Arg Leu Arg Gly Gln Gly Ser Tyr Asp Glu
1745                1750                1755                1760
Arg Tyr Met Leu Pro His Gln Pro
                1765            


<210> 8514
<211> 420
<212> PRT
<213> Homo sapiens

<400> 8514
Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro
 1               5                  10                  15      
Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys
            20                  25                  30          
Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro
        35                  40                  45              
Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn
    50                  55                  60                  
Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu
65                  70                  75                  80  
Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg
                85                  90                  95      
Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu
            100                 105                 110         
Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu
        115                 120                 125             
Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg
    130                 135                 140                 
His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu
145                 150                 155                 160 
Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly
                165                 170                 175     
Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp
            180                 185                 190         
Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val
        195                 200                 205             
Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala
    210                 215                 220                 
Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val
225                 230                 235                 240 
Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile
                245                 250                 255     
Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val
            260                 265                 270         
Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr
        275                 280                 285             
Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val
    290                 295                 300                 
Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu
305                 310                 315                 320 
Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala
                325                 330                 335     
His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn
            340                 345                 350         
Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser
        355                 360                 365             
Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile
    370                 375                 380                 
Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala
385                 390                 395                 400 
Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala
                405                 410                 415     
Ser Asn Ser Thr
            420 


<210> 8515
<211> 433
<212> PRT
<213> Homo sapiens

<400> 8515
Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro
 1               5                  10                  15      
Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys
            20                  25                  30          
Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro
        35                  40                  45              
Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn
    50                  55                  60                  
Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu
65                  70                  75                  80  
Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg
                85                  90                  95      
Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu
            100                 105                 110         
Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu
        115                 120                 125             
Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg
    130                 135                 140                 
His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu
145                 150                 155                 160 
Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly
                165                 170                 175     
Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp
            180                 185                 190         
Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val
        195                 200                 205             
Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala
    210                 215                 220                 
Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val
225                 230                 235                 240 
Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile
                245                 250                 255     
Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val
            260                 265                 270         
Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr
        275                 280                 285             
Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp
    290                 295                 300                 
Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro
305                 310                 315                 320 
Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr
                325                 330                 335     
Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe
            340                 345                 350         
Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp
        355                 360                 365             
Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro
    370                 375                 380                 
Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala
385                 390                 395                 400 
Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly
                405                 410                 415     
Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser
            420                 425                 430         
Thr
    


<210> 8516
<211> 672
<212> PRT
<213> Homo sapiens

<400> 8516
Gln Gly Lys Ala Leu Tyr Asp Phe Glu Met Lys Asp Lys Asp Gln Asp
 1               5                  10                  15      
Lys Asp Cys Leu Thr Phe Thr Lys Asp Glu Ile Leu Thr Val Leu Arg
            20                  25                  30          
Arg Val Asp Glu Asn Trp Ala Glu Gly Met Leu Gly Asp Lys Ile Gly
        35                  40                  45              
Ile Phe Pro Leu Leu Tyr Val Glu Leu Asn Asp Ser Ala Lys Gln Leu
    50                  55                  60                  
Ile Glu Met Asp Lys Pro Cys Pro Ala Ala Ala Ser Ser Cys Asn Ala
65                  70                  75                  80  
Ser Leu Pro Ser Asp Ser Gly Ala Val Ala Ser Val Ala Pro Ser Pro
                85                  90                  95      
Thr Leu Ser Ser Ser Gly Ala Val Ser Ala Phe Gln Arg Arg Val Asp
            100                 105                 110         
Gly Lys Lys Asn Thr Lys Lys Arg His Ser Phe Thr Ala Leu Ser Val
        115                 120                 125             
Thr His Arg Ser Ser Gln Ala Ala Ser His Arg His Ser Met Glu Ile
    130                 135                 140                 
Ser Ala Pro Val Leu Ile Ser Ser Ser Asp Pro Arg Ala Ala Ala Arg
145                 150                 155                 160 
Ile Gly Asp Leu Ala His Leu Ser Cys Ala Ala Pro Thr Gln Val Thr
                165                 170                 175     
Ser Arg Gly Pro Gly Gln Ala Ser Leu Gly Ser Leu Gly Phe Tyr Pro
            180                 185                 190         
Gln Leu Arg Ala Arg Ala Arg Ser Ser Glu His Leu His Ser Ser Ser
        195                 200                 205             
Pro Cys Leu Gln Leu Leu Val Ala Ser Glu Leu Leu Ser Leu Leu Gln
    210                 215                 220                 
Pro Phe His Arg Thr Tyr Pro Ala Leu Pro Ser Pro Leu Ala Ser Ser
225                 230                 235                 240 
Ala Ala Pro Asp Ser Thr Pro Ala Val Gly Leu Pro Cys Arg Val Gly
                245                 250                 255     
Ala Ala Pro Arg Trp Lys Arg Tyr Leu Ala Leu Tyr Ala Tyr Lys Pro
            260                 265                 270         
Gln Lys Ser Asp Glu Leu Glu Leu His Lys Gly Glu Met Tyr Arg Val
        275                 280                 285             
Leu Glu Lys Cys Gln Asp Gly Trp Phe Lys Gly Ala Ser Leu Arg Thr
    290                 295                 300                 
Gly Val Ser Gly Val Phe Pro Gly Asn Tyr Val Thr Pro Val Ser Arg
305                 310                 315                 320 
Val Pro Ala Gly Gly Ala Gly Pro Pro Arg Asn Asn Val Val Gly Gly
                325                 330                 335     
Ser Pro Leu Ala Lys Gly Ile Thr Thr Thr Met His Pro Gly Ser Gly
            340                 345                 350         
Ser Leu Ser Ser Leu Ala Thr Ala Thr Arg Pro Ala Leu Pro Ile Thr
        355                 360                 365             
Thr Pro Gln Ala His Ala Gln His Pro Thr Ala Ser Pro Pro Thr Gly
    370                 375                 380                 
Ser Cys Leu Arg His Ser Ala Gln Pro Thr Ala Ser Gln Ala Arg Ser
385                 390                 395                 400 
Thr Ile Ser Thr Ala Ala His Ser Ala Ala Gln Ala Gln Asp Arg Pro
                405                 410                 415     
Thr Ala Thr Val Ser Pro Leu Arg Thr Gln Asn Ser Pro Ser Arg Leu
            420                 425                 430         
Pro Ala Thr Ser Leu Arg Pro His Ser Val Val Ser Pro Gln His Ser
        435                 440                 445             
His Gln Pro Pro Val Gln Met Cys Pro Arg Pro Ala Ile Pro Leu Thr
    450                 455                 460                 
Ser Ala Ala Ser Ala Ile Thr Pro Pro Asn Val Ser Ala Ala Asn Leu
465                 470                 475                 480 
Asn Gly Glu Ala Gly Gly Gly Pro Ile Gly Val Leu Ser Thr Ser Ser
                485                 490                 495     
Pro Thr Asn Thr Gly Cys Lys Leu Asp Glu Lys Lys Ser Glu Lys Leu
            500                 505                 510         
Cys His Met Arg Ser Gln Ser Phe Asp Leu Leu Ser Pro Cys Leu Ser
        515                 520                 525             
Pro Pro Gln Ala Ala Gly Ala Gly Val Ala Phe Pro Val Asn Ser Ser
    530                 535                 540                 
Cys Asp Cys Pro His Gln Gln Pro His His Pro Leu Leu Ser Trp Leu
545                 550                 555                 560 
Gly Ser Ser Glu Ala Pro Leu Gln Pro Gly Pro His Pro Ala Asp Cys
                565                 570                 575     
Met Ala Phe Lys Pro Pro Thr Thr Pro Ala Ile Pro Val Pro Pro Pro
            580                 585                 590         
Leu Ser Gln Leu Leu Gly Cys Ser Gln His Gly Asp Cys Leu Cys Gly
        595                 600                 605             
Ala His Pro Leu Cys Cys Phe Pro Arg Tyr Arg Val Val Val Ser Tyr
    610                 615                 620                 
Pro Pro Gln Ser Glu Ala Glu Ile Glu Leu Lys Glu Gly Asp Ile Val
625                 630                 635                 640 
Phe Val His Lys Lys Arg Glu Asp Gly Trp Tyr Lys Gly Thr Leu Gln
                645                 650                 655     
Arg Asn Gly Arg Thr Gly Leu Phe Pro Gly Ser Phe Val Glu Ser Phe
            660                 665                 670         


<210> 8517
<211> 452
<212> PRT
<213> Homo sapiens

<400> 8517
Met Asp Glu Ser Ser Leu Leu Asp Leu Leu Glu Cys Ser Val Cys Leu
 1               5                  10                  15      
Glu Arg Leu Asp Thr Thr Ala Lys Val Leu Pro Cys Gln His Thr Phe
            20                  25                  30          
Cys Arg Arg Cys Leu Glu Ser Ile Val Cys Ser Arg His Glu Leu Arg
        35                  40                  45              
Cys Pro Glu Cys Arg Ile Leu Val Gly Cys Gly Val Asp Glu Leu Pro
    50                  55                  60                  
Ala Asn Ile Leu Leu Val Arg Leu Leu Asp Gly Ile Gln Thr Met Gln
65                  70                  75                  80  
Trp Val Gly Arg Gly Gly His Arg Lys Pro Leu Arg Ser Pro Gly Leu
                85                  90                  95      
Pro Arg Gln Ile His Cys Gly Ala Leu Gly Arg Gly Met Pro Gly Asp
            100                 105                 110         
His Met Leu Ser Val Ala Cys Arg Ile Pro Leu Leu Pro Tyr Gly Lys
        115                 120                 125             
Ala Leu Tyr Ser Tyr Glu Gly Lys Glu Pro Gly Asp Leu Lys Phe Asn
    130                 135                 140                 
Lys Gly Asp Ile Ile Val Leu Arg Arg Lys Val Asp Glu Gln Trp Tyr
145                 150                 155                 160 
His Gly Glu Leu His Gly Thr Gln Gly Phe Leu Pro Ala Ser Tyr Ile
                165                 170                 175     
Gln Cys Ile Gln Pro Leu Pro His Ala Pro Pro Gln Gly Lys Ala Leu
            180                 185                 190         
Tyr Asp Phe Glu Met Lys Asp Lys Asp Gln Asp Lys Asp Cys Leu Thr
        195                 200                 205             
Phe Thr Lys Asp Glu Ile Leu Thr Val Leu Arg Arg Val Asp Glu Asn
    210                 215                 220                 
Trp Ala Glu Gly Met Leu Gly Asp Lys Ile Gly Ile Phe Pro Leu Leu
225                 230                 235                 240 
Tyr Val Glu Leu Asn Asp Ser Ala Lys Gln Leu Ile Glu Met Asp Lys
                245                 250                 255     
Pro Cys Pro Ala Ala Ala Ser Ser Cys Asn Ala Ser Leu Pro Ser Asp
            260                 265                 270         
Ser Gly Ala Val Ala Ser Val Ala Pro Ser Pro Thr Leu Ser Ser Ser
        275                 280                 285             
Gly Ala Val Ser Ala Phe Gln Arg Arg Val Asp Gly Lys Lys Asn Thr
    290                 295                 300                 
Lys Lys Arg His Ser Phe Thr Ala Leu Ser Val Thr His Arg Ser Ser
305                 310                 315                 320 
Gln Ala Ala Ser His Arg His Ser Met Glu Ile Ser Ala Pro Val Leu
                325                 330                 335     
Ile Ser Ser Ser Asp Pro Arg Ala Ala Ala Arg Ile Gly Asp Leu Ala
            340                 345                 350         
His Leu Ser Cys Ala Ala Pro Thr Gln Val Thr Ser Arg Gly Pro Gly
        355                 360                 365             
Gln Ala Ser Leu Gly Ser Leu Gly Phe Tyr Pro Gln Leu Arg Gly Leu
    370                 375                 380                 
Pro Leu Thr Leu Ala Pro Cys Phe Ala Arg Arg Tyr Leu Ala Leu Tyr
385                 390                 395                 400 
Ala Tyr Lys Pro Gln Lys Ser Asp Glu Leu Glu Leu His Lys Gly Glu
                405                 410                 415     
Met Tyr Arg Val Leu Glu Lys Cys Gln Asp Gly Trp Phe Lys Gly Ala
            420                 425                 430         
Ser Leu Arg Thr Gly Val Ser Gly Val Phe Pro Gly Asn Tyr Val Thr
        435                 440                 445             
Pro Val Ser Arg
    450         


<210> 8518
<211> 883
<212> PRT
<213> Homo sapiens

<400> 8518
Met Asp Glu Ser Ser Leu Leu Asp Leu Leu Glu Cys Ser Val Cys Leu
 1               5                  10                  15      
Glu Arg Leu Asp Thr Thr Ala Lys Val Leu Pro Cys Gln His Thr Phe
            20                  25                  30          
Cys Arg Arg Cys Leu Glu Ser Ile Val Cys Ser Arg His Glu Leu Arg
        35                  40                  45              
Cys Pro Glu Cys Arg Ile Leu Val Gly Cys Gly Val Asp Glu Leu Pro
    50                  55                  60                  
Ala Asn Ile Leu Leu Val Arg Leu Leu Asp Gly Ile Arg Gln Cys Pro
65                  70                  75                  80  
Arg Pro Gly Pro Val Arg Pro Thr Gln Ala Asn Thr Leu His Met Gly
                85                  90                  95      
Gln Cys Pro Gln Pro Cys Gln Cys Ser Pro Pro Arg Cys Val Phe Pro
            100                 105                 110         
Pro His His Gln Thr Ser Ala Pro Gln Pro Gly Gln Cys Pro Arg Gln
        115                 120                 125             
Pro Trp Asn Pro Cys Leu Leu Pro Tyr Gly Lys Ala Leu Tyr Ser Tyr
    130                 135                 140                 
Glu Gly Lys Glu Pro Gly Asp Leu Lys Phe Asn Lys Gly Asp Ile Ile
145                 150                 155                 160 
Val Leu Arg Arg Lys Val Asp Glu Gln Trp Tyr His Gly Glu Leu His
                165                 170                 175     
Gly Thr Gln Gly Phe Leu Pro Ala Ser Tyr Ile Gln Cys Ile Gln Pro
            180                 185                 190         
Leu Pro His Ala Pro Pro Gln Gly Lys Ala Leu Tyr Asp Phe Glu Met
        195                 200                 205             
Lys Asp Lys Asp Gln Asp Lys Asp Cys Leu Thr Phe Thr Lys Asp Glu
    210                 215                 220                 
Ile Leu Thr Val Leu Arg Arg Val Asp Glu Asn Trp Ala Glu Gly Met
225                 230                 235                 240 
Leu Gly Asp Lys Ile Gly Ile Phe Pro Leu Leu Tyr Val Glu Leu Asn
                245                 250                 255     
Asp Ser Ala Lys Gln Leu Ile Glu Met Asp Lys Pro Cys Pro Ala Ala
            260                 265                 270         
Ala Ser Ser Cys Asn Ala Ser Leu Pro Ser Asp Ser Gly Ala Val Ala
        275                 280                 285             
Ser Val Ala Pro Ser Pro Thr Leu Ser Ser Ser Gly Ala Val Ser Ala
    290                 295                 300                 
Phe Gln Arg Arg Val Asp Gly Lys Lys Asn Thr Lys Lys Arg His Ser
305                 310                 315                 320 
Phe Thr Ala Leu Ser Val Thr His Arg Ser Ser Gln Ala Ala Ser His
                325                 330                 335     
Arg His Ser Met Glu Ile Ser Ala Pro Val Leu Ile Ser Ser Ser Asp
            340                 345                 350         
Pro Arg Ala Ala Ala Arg Ile Gly Asp Leu Ala His Leu Ser Cys Ala
        355                 360                 365             
Ala Pro Thr Gln Val Thr Ser Arg Gly Pro Gly Gln Ala Ser Leu Gly
    370                 375                 380                 
Ser Leu Gly Ala Ser Ala Thr Ile Thr Gly Ala Thr Val Ala Ala Ala
385                 390                 395                 400 
Ile Pro Thr Asn Ser Pro Leu Ser Val Ser Arg Pro Pro Pro Asp Ser
                405                 410                 415     
Leu Ala Leu Cys Arg Cys Arg Leu Gly Ser Leu Ala Leu Pro Asp Gly
            420                 425                 430         
Phe Pro Ala Lys Leu Gln Val Leu Ala Val Ala Ala Phe Ser Leu Pro
        435                 440                 445             
Val Leu Gln Gly Arg Arg Ala Leu Arg Leu Lys Thr Arg Thr Leu Ser
    450                 455                 460                 
Gly Gly Pro Thr Gln Pro Val Leu Ile Pro Tyr Leu Ala Leu Tyr Ala
465                 470                 475                 480 
Tyr Lys Pro Gln Lys Ser Asp Glu Leu Glu Leu His Lys Gly Glu Met
                485                 490                 495     
Tyr Arg Val Leu Glu Lys Cys Gln Asp Gly Trp Phe Lys Gly Ala Ser
            500                 505                 510         
Leu Arg Thr Gly Val Ser Gly Val Phe Pro Gly Asn Tyr Val Thr Pro
        515                 520                 525             
Val Ser Arg Val Pro Ala Gly Gly Ala Gly Pro Pro Arg Asn Asn Val
    530                 535                 540                 
Val Gly Gly Ser Pro Leu Ala Lys Gly Ile Thr Thr Thr Met His Pro
545                 550                 555                 560 
Gly Ser Gly Ser Leu Ser Ser Leu Ala Thr Ala Thr Arg Pro Ala Leu
                565                 570                 575     
Pro Ile Thr Thr Pro Gln Ala His Ala Gln His Pro Thr Ala Ser Pro
            580                 585                 590         
Pro Thr Gly Ser Cys Leu Arg His Ser Ala Gln Pro Thr Ala Ser Gln
        595                 600                 605             
Ala Arg Ser Thr Ile Ser Thr Ala Ala His Ser Ala Ala Gln Ala Gln
    610                 615                 620                 
Asp Arg Pro Thr Ala Thr Val Ser Pro Leu Arg Thr Gln Asn Ser Pro
625                 630                 635                 640 
Ser Arg Leu Pro Ala Thr Ser Leu Arg Pro His Ser Val Val Ser Pro
                645                 650                 655     
Gln His Ser His Gln Pro Pro Val Gln Met Cys Pro Arg Pro Ala Ile
            660                 665                 670         
Pro Leu Thr Ser Ala Ala Ser Ala Ile Thr Pro Pro Asn Val Ser Ala
        675                 680                 685             
Ala Asn Leu Asn Gly Glu Ala Gly Gly Gly Pro Ile Gly Val Leu Ser
    690                 695                 700                 
Thr Ser Ser Pro Thr Asn Thr Gly Cys Lys Leu Asp Glu Lys Lys Ser
705                 710                 715                 720 
Glu Lys Leu Cys His Met Arg Ser Gln Ser Phe Asp Leu Leu Ser Pro
                725                 730                 735     
Cys Leu Ser Pro Pro Gln Ala Ala Gly Ala Gly Val Ala Phe Pro Val
            740                 745                 750         
Asn Ser Ser Cys Asp Cys Pro His Gln Gln Pro His His Pro Leu Leu
        755                 760                 765             
Ser Trp Leu Gly Ser Ser Glu Ala Pro Leu Gln Pro Gly Pro His Pro
    770                 775                 780                 
Ala Asp Cys Met Ala Phe Lys Pro Pro Thr Thr Pro Ala Ile Pro Val
785                 790                 795                 800 
Pro Pro Pro Leu Ser Gln Leu Leu Gly Cys Ser Gln His Gly Asp Cys
                805                 810                 815     
Leu Cys Gly Ala His Pro Leu Cys Cys Phe Pro Arg Tyr Arg Val Val
            820                 825                 830         
Val Ser Tyr Pro Pro Gln Ser Glu Ala Glu Ile Glu Leu Lys Glu Gly
        835                 840                 845             
Asp Ile Val Phe Val His Lys Lys Arg Glu Asp Gly Trp Tyr Lys Gly
    850                 855                 860                 
Thr Leu Gln Arg Asn Gly Arg Thr Gly Leu Phe Pro Gly Ser Phe Val
865                 870                 875                 880 
Glu Ser Phe
            


<210> 8519
<211> 683
<212> PRT
<213> Homo sapiens

<400> 8519
Met Asp Glu Ser Ser Leu Leu Asp Leu Leu Glu Cys Ser Val Cys Leu
 1               5                  10                  15      
Glu Arg Leu Asp Thr Thr Ala Lys Val Leu Pro Cys Gln His Thr Phe
            20                  25                  30          
Cys Arg Arg Cys Leu Glu Ser Ile Val Cys Ser Arg His Glu Leu Arg
        35                  40                  45              
Cys Pro Glu Cys Arg Ile Leu Val Gly Cys Gly Val Asp Glu Leu Pro
    50                  55                  60                  
Ala Asn Ile Leu Leu Val Arg Leu Leu Asp Gly Ile Arg Gln Cys Pro
65                  70                  75                  80  
Arg Pro Gly Pro Val Arg Pro Thr Gln Ala Asn Thr Leu His Met Gly
                85                  90                  95      
Gln Cys Pro Gln Pro Cys Gln Cys Ser Pro Pro Arg Cys Val Phe Pro
            100                 105                 110         
Pro His His Gln Thr Ser Ala Pro Gln Pro Gly Gln Cys Pro Arg Gln
        115                 120                 125             
Pro Trp Asn Pro Cys Leu Leu Pro Tyr Gly Lys Ala Leu Tyr Ser Tyr
    130                 135                 140                 
Glu Gly Lys Glu Pro Gly Asp Leu Lys Phe Asn Lys Gly Asp Ile Ile
145                 150                 155                 160 
Val Leu Arg Arg Lys Val Asp Glu Gln Trp Tyr His Gly Glu Leu His
                165                 170                 175     
Gly Thr Gln Gly Phe Leu Pro Ala Ser Tyr Ile Gln Cys Ile Gln Pro
            180                 185                 190         
Leu Pro His Ala Pro Pro Gln Gly Lys Ala Leu Tyr Asp Phe Glu Met
        195                 200                 205             
Lys Asp Lys Asp Gln Asp Lys Asp Cys Leu Thr Phe Thr Lys Asp Glu
    210                 215                 220                 
Ile Leu Thr Val Leu Arg Arg Val Asp Glu Asn Trp Ala Glu Gly Met
225                 230                 235                 240 
Leu Gly Asp Lys Ile Gly Ile Phe Pro Leu Leu Tyr Val Glu Leu Asn
                245                 250                 255     
Asp Ser Ala Lys Gln Leu Ile Glu Met Asp Lys Pro Cys Pro Ala Ala
            260                 265                 270         
Ala Ser Ser Cys Asn Ala Ser Leu Pro Ser Asp Ser Gly Ala Val Ala
        275                 280                 285             
Ser Val Ala Pro Ser Pro Thr Leu Ser Ser Ser Gly Ala Val Ser Ala
    290                 295                 300                 
Phe Gln Arg Arg Val Asp Gly Lys Lys Asn Thr Lys Lys Arg His Ser
305                 310                 315                 320 
Phe Thr Ala Leu Ser Val Thr His Arg Ser Ser Gln Ala Ala Ser His
                325                 330                 335     
Arg His Ser Met Glu Ile Ser Ala Pro Val Leu Ile Ser Ser Ser Asp
            340                 345                 350         
Pro Arg Ala Ala Ala Arg Ile Gly Asp Leu Ala His Leu Ser Cys Ala
        355                 360                 365             
Ala Pro Thr Gln Val Thr Ser Arg Gly Ala Gly Ile Pro Gly Phe Ser
    370                 375                 380                 
Gly Val Leu Ser Ser Ala Pro Cys Ser Val Ser Pro Val Pro Gln Leu
385                 390                 395                 400 
Ala Trp Arg Pro Pro Gln Asn Cys Leu Leu Gly Leu Ser Gly Val Cys
                405                 410                 415     
Pro Leu Leu Pro Gly Thr Gly Ala Pro Leu Glu Ala Trp Arg Met Val
            420                 425                 430         
Ser Val Pro Ser Leu Val Gln Lys Met Ala Ser Trp Tyr Leu Ala Leu
        435                 440                 445             
Tyr Ala Tyr Lys Pro Gln Lys Ser Asp Glu Leu Glu Leu His Lys Gly
    450                 455                 460                 
Glu Met Tyr Arg Val Leu Glu Lys Cys Gln Asp Gly Trp Phe Lys Gly
465                 470                 475                 480 
Ala Ser Leu Arg Thr Gly Val Ser Gly Val Phe Pro Gly Asn Tyr Val
                485                 490                 495     
Thr Pro Val Ser Arg Lys Cys Thr Pro Ser Asn Pro Ala Thr Trp Val
            500                 505                 510         
Pro Ala Gly Gly Ala Gly Pro Pro Arg Asn Asn Val Val Gly Gly Ser
        515                 520                 525             
Pro Leu Ala Lys Gly Ile Thr Thr Thr Met His Pro Gly Ser Gly Ser
    530                 535                 540                 
Leu Ser Ser Leu Ala Thr Ala Thr Arg Pro Ala Leu Pro Ile Thr Thr
545                 550                 555                 560 
Pro Gln Ala His Ala Gln His Pro Thr Ala Ser Pro Pro Thr Gly Ser
                565                 570                 575     
Cys Leu Arg His Ser Ala Gln Pro Thr Ala Ser Gln Ala Arg Ser Thr
            580                 585                 590         
Ile Ser Thr Ala Ala His Ser Ala Ala Gln Ala Gln Asp Arg Pro Thr
        595                 600                 605             
Ala Thr Val Ser Pro Leu Arg Thr Gln Asn Ser Pro Ser Arg Leu Pro
    610                 615                 620                 
Ala Thr Ser Leu Arg Pro His Ser Val Val Ser Pro Gln His Ser His
625                 630                 635                 640 
Gln Pro Pro Val Gln Met Cys Pro Arg Pro Ala Ile Pro Leu Thr Ser
                645                 650                 655     
Ala Ala Ser Ala Ile Thr Pro Pro Asn Val Ser Ala Ala Asn Leu Asn
            660                 665                 670         
Gly Glu Ala Gly Gly Gly Pro Ile Gly Val Leu
        675                 680             


<210> 8520
<211> 1121
<212> PRT
<213> Homo sapiens

<400> 8520
Met Ser Leu Glu Asn Glu Asp Lys Arg Ala Arg Thr Arg Ser Lys Ala
 1               5                  10                  15      
Leu Arg Gly Pro Pro Glu Thr Thr Ala Ala Asp Leu Ser Cys Pro Thr
            20                  25                  30          
Pro Gly Cys Thr Gly Ser Gly His Val Arg Gly Lys Tyr Ser Arg His
        35                  40                  45              
Arg Ser Leu Gln Ser Cys Pro Leu Ala Lys Lys Arg Lys Leu Glu Gly
    50                  55                  60                  
Ala Glu Ala Glu His Leu Val Ser Lys Arg Lys Ser His Pro Leu Lys
65                  70                  75                  80  
Leu Ala Leu Asp Glu Gly Tyr Gly Val Asp Ser Asp Gly Ser Glu Asp
                85                  90                  95      
Thr Glu Val Lys Asp Ala Ser Val Ser Asp Glu Ser Glu Gly Thr Leu
            100                 105                 110         
Glu Gly Ala Glu Ala Glu Thr Ser Gly Gln Asp Glu Ile His Arg Pro
        115                 120                 125             
Glu Thr Ala Glu Gly Arg Ser Pro Val Lys Ser His Phe Gly Ser Asn
    130                 135                 140                 
Pro Ile Gly Ser Ala Thr Ala Ser Ser Lys Gly Ser Tyr Ser Ser Tyr
145                 150                 155                 160 
Gln Gly Ile Ile Ala Thr Ser Leu Leu Asn Leu Gly Gln Ile Ala Glu
                165                 170                 175     
Glu Thr Leu Val Glu Glu Asp Leu Gly Gln Ala Ala Lys Pro Gly Pro
            180                 185                 190         
Gly Ile Val His Leu Leu Gln Glu Ala Ala Glu Gly Ala Ala Ser Glu
        195                 200                 205             
Glu Gly Glu Lys Gly Leu Phe Ile Gln Pro Glu Asp Ala Glu Glu Val
    210                 215                 220                 
Val Glu Val Thr Thr Glu Arg Ser Gln Asp Leu Cys Pro Gln Ser Leu
225                 230                 235                 240 
Glu Asp Ala Ala Ser Glu Glu Ser Ser Lys Gln Lys Gly Ile Leu Ser
                245                 250                 255     
His Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            260                 265                 270         
Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
        275                 280                 285             
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    290                 295                 300                 
Glu Glu Ala Ala Pro Asp Val Ile Phe Gln Glu Asp Thr Ser His Thr
305                 310                 315                 320 
Ser Ala Gln Lys Ala Pro Glu Leu Arg Gly Pro Glu Ser Pro Ser Pro
                325                 330                 335     
Lys Pro Glu Tyr Ser Val Ile Val Glu Val Arg Ser Asp Asp Asp Lys
            340                 345                 350         
Asp Glu Asp Thr His Ser Arg Lys Ser Thr Val Thr Asp Glu Ser Glu
        355                 360                 365             
Met Gln Asp Met Met Thr Arg Gly Asn Leu Gly Leu Leu Glu Gln Ala
    370                 375                 380                 
Ile Ala Leu Lys Ala Glu Gln Val Arg Thr Val Cys Glu Pro Gly Cys
385                 390                 395                 400 
Pro Pro Ala Glu Gln Ser Gln Leu Gly Leu Gly Glu Pro Gly Lys Ala
                405                 410                 415     
Ala Lys Pro Leu Asp Thr Val Arg Lys Ser Tyr Tyr Ser Lys Asp Pro
            420                 425                 430         
Ser Arg Ala Glu Lys Arg Glu Ile Lys Cys Pro Thr Pro Gly Cys Asp
        435                 440                 445             
Gly Thr Gly His Val Thr Gly Leu Tyr Pro His His Arg Ser Leu Ser
    450                 455                 460                 
Gly Cys Pro His Lys Asp Arg Ile Pro Pro Glu Ile Leu Ala Met His
465                 470                 475                 480 
Glu Asn Val Leu Lys Cys Pro Thr Pro Gly Cys Thr Gly Gln Gly His
                485                 490                 495     
Val Asn Ser Asn Arg Asn Thr His Arg Ser Leu Ser Gly Cys Pro Ile
            500                 505                 510         
Ala Ala Ala Glu Lys Leu Ala Lys Ser His Glu Lys Gln Gln Pro Gln
        515                 520                 525             
Thr Gly Asp Pro Ser Lys Ser Ser Ser Asn Ser Asp Arg Ile Leu Arg
    530                 535                 540                 
Pro Met Cys Phe Val Lys Gln Leu Glu Val Pro Pro Tyr Gly Ser Tyr
545                 550                 555                 560 
Arg Pro Asn Val Ala Pro Ala Thr Pro Arg Ala Asn Leu Ala Lys Glu
                565                 570                 575     
Leu Glu Lys Phe Ser Lys Val Thr Phe Asp Tyr Ala Ser Phe Asp Ala
            580                 585                 590         
Gln Val Phe Gly Lys Arg Met Leu Ala Pro Lys Ile Gln Thr Ser Glu
        595                 600                 605             
Thr Ser Pro Lys Ala Phe Gln Cys Phe Asp Tyr Ser Gln Asp Ala Glu
    610                 615                 620                 
Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn Leu Ser Thr Arg Cys
625                 630                 635                 640 
Trp Glu Met Pro Glu Asn Leu Ser Thr Lys Pro Gln Asp Leu Pro Ser
                645                 650                 655     
Lys Ser Val Asp Ile Glu Val Asp Glu Asn Gly Thr Leu Asp Leu Ser
            660                 665                 670         
Met His Lys His Arg Lys Arg Glu Asn Ala Phe Pro Ser Ser Ser Ser
        675                 680                 685             
Cys Ser Ser Ser Pro Gly Val Lys Ser Pro Asp Ala Ser Gln Arg His
    690                 695                 700                 
Ser Ser Thr Ser Ala Pro Ser Ser Ser Met Thr Ser Pro Gln Ser Ser
705                 710                 715                 720 
Gln Ala Ser Arg Gln Asp Glu Trp Asp Arg Pro Leu Asp Tyr Thr Lys
                725                 730                 735     
Pro Ser Arg Leu Arg Glu Glu Glu Pro Glu Glu Ser Glu Pro Ala Ala
            740                 745                 750         
His Ser Phe Ala Ser Ser Glu Ala Asp Asp Gln Glu Val Ser Glu Glu
        755                 760                 765             
Asn Phe Glu Glu Arg Lys Tyr Pro Gly Glu Val Thr Leu Thr Asn Phe
    770                 775                 780                 
Lys Leu Lys Phe Leu Ser Lys Asp Ile Lys Lys Glu Leu Leu Thr Cys
785                 790                 795                 800 
Pro Thr Pro Gly Cys Asp Gly Ser Gly His Ile Thr Gly Asn Tyr Ala
                805                 810                 815     
Ser His Arg Ser Leu Ser Gly Cys Pro Leu Ala Asp Lys Ser Leu Arg
            820                 825                 830         
Asn Leu Met Ala Ala His Ser Ala Asp Leu Lys Cys Pro Thr Pro Gly
        835                 840                 845             
Cys Asp Gly Ser Gly His Ile Thr Gly Asn Tyr Ala Ser His Arg Ser
    850                 855                 860                 
Leu Ser Gly Cys Pro Arg Ala Lys Lys Ser Gly Val Lys Val Ala Pro
865                 870                 875                 880 
Thr Lys Asp Asp Lys Glu Asp Pro Glu Leu Met Lys Cys Pro Val Pro
                885                 890                 895     
Gly Cys Val Gly Leu Gly His Ile Ser Gly Lys Tyr Ala Ser His Arg
            900                 905                 910         
Ser Ala Ser Gly Cys Pro Leu Ala Ala Arg Arg Gln Lys Glu Gly Ser
        915                 920                 925             
Leu Asn Gly Ser Ser Phe Ser Trp Lys Ser Leu Lys Asn Glu Gly Pro
    930                 935                 940                 
Thr Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His Ala Asn Gly Ser
945                 950                 955                 960 
Phe Leu Thr His Arg Ser Leu Ser Gly Cys Pro Arg Ala Thr Phe Ala
                965                 970                 975     
Gly Lys Lys Gly Lys Leu Ser Gly Asp Glu Val Leu Ser Pro Lys Phe
            980                 985                 990         
Lys Thr Ser Asp Val Leu Glu Asn Asp Glu Glu Ile Lys Gln Leu Asn
        995                 1000                1005            
Gln Glu Ile Arg Asp Leu Asn Glu Ser Asn Ser Glu Met Glu Ala Ala
    1010                1015                1020                
Met Val Gln Leu Gln Ser Gln Ile Ser Ser Met Glu Lys Asn Leu Lys
1025                1030                1035                1040
Asn Ile Glu Glu Glu Asn Lys Leu Ile Glu Glu Gln Asn Glu Ala Leu
                1045                1050                1055    
Phe Leu Glu Leu Ser Gly Leu Ser Gln Ala Leu Ile Gln Ser Leu Ala
            1060                1065                1070        
Asn Ile Arg Leu Pro His Met Glu Pro Ile Cys Glu Gln Asn Phe Asp
        1075                1080                1085            
Ala Tyr Val Ser Thr Leu Thr Asp Met Tyr Ser Asn Gln Asp Pro Glu
    1090                1095                1100                
Asn Lys Asp Leu Leu Glu Ser Ile Lys Gln Ala Val Arg Gly Ile Gln
1105                1110                1115                1120
Val
    


<210> 8521
<211> 1105
<212> PRT
<213> Homo sapiens

<400> 8521
Met Ala Ala Met Ala Pro Ala Leu Thr Asp Ala Ala Ala Glu Ala His
 1               5                  10                  15      
His Ile Arg Phe Lys Leu Ala Pro Pro Ser Ser Thr Leu Ser Pro Gly
            20                  25                  30          
Ser Ala Glu Asn Asn Gly Asn Ala Asn Ile Leu Ile Ala Ala Asn Gly
        35                  40                  45              
Thr Lys Arg Lys Ala Ile Ala Ala Glu Asp Pro Ser Leu Asp Phe Arg
    50                  55                  60                  
Asn Asn Pro Thr Lys Glu Asp Leu Gly Lys Leu Gln Pro Leu Val Ala
65                  70                  75                  80  
Ser Tyr Leu Cys Ser Asp Val Thr Ser Val Pro Ser Lys Glu Ser Leu
                85                  90                  95      
Lys Leu Gln Gly Val Phe Ser Lys Gln Thr Val Leu Lys Ser His Pro
            100                 105                 110         
Leu Leu Ser Gln Ser Tyr Glu Leu Arg Ala Glu Leu Leu Gly Arg Gln
        115                 120                 125             
Pro Val Leu Glu Phe Ser Leu Glu Asn Leu Arg Thr Met Asn Thr Ser
    130                 135                 140                 
Gly Gln Thr Ala Leu Pro Gln Ala Pro Val Asn Gly Leu Ala Lys Lys
145                 150                 155                 160 
Leu Thr Lys Ser Ser Thr His Ser Asp His Asp Asn Ser Thr Ser Leu
                165                 170                 175     
Asn Gly Gly Lys Arg Ala Leu Thr Ser Ser Ala Leu His Gly Gly Glu
            180                 185                 190         
Met Gly Gly Ser Glu Ser Gly Asp Leu Lys Gly Gly Met Thr Asn Cys
        195                 200                 205             
Thr Leu Pro His Arg Ser Leu Asp Val Glu His Thr Thr Leu Tyr Ser
    210                 215                 220                 
Asn Asn Ser Thr Ala Asn Lys Ser Ser Val Asn Ser Met Glu Gln Pro
225                 230                 235                 240 
Ala Leu Gln Gly Ser Ser Arg Leu Ser Pro Gly Thr Asp Ser Ser Ser
                245                 250                 255     
Asn Leu Gly Gly Val Lys Leu Glu Gly Lys Lys Ser Pro Leu Ser Ser
            260                 265                 270         
Ile Leu Phe Ser Ala Leu Asp Ser Asp Thr Arg Ile Thr Ala Leu Leu
        275                 280                 285             
Arg Arg Gln Ala Asp Ile Glu Ser Arg Ala Arg Arg Leu Gln Lys Arg
    290                 295                 300                 
Leu Gln Val Val Gln Ala Lys Gln Val Glu Arg His Ile Gln His Gln
305                 310                 315                 320 
Leu Gly Gly Phe Leu Glu Lys Thr Leu Ser Lys Leu Pro Asn Leu Glu
                325                 330                 335     
Ser Leu Arg Pro Arg Ser Gln Leu Met Leu Thr Arg Lys Ala Glu Ala
            340                 345                 350         
Ala Leu Arg Lys Ala Ala Ser Glu Thr Thr Thr Ser Glu Gly Leu Ser
        355                 360                 365             
Asn Phe Leu Lys Ser Asn Ser Ile Ser Glu Glu Leu Glu Arg Phe Thr
    370                 375                 380                 
Ala Ser Gly Ile Ala Asn Leu Arg Cys Ser Glu Gln Ala Phe Asp Ser
385                 390                 395                 400 
Asp Val Thr Asp Ser Ser Ser Gly Gly Glu Ser Asp Ile Glu Glu Glu
                405                 410                 415     
Glu Leu Thr Arg Ala Asp Pro Glu Gln Arg His Val Pro Leu Arg Arg
            420                 425                 430         
Arg Ser Glu Trp Lys Trp Ala Ala Asp Arg Ala Ala Ile Val Ser Arg
        435                 440                 445             
Trp Asn Trp Leu Gln Ala His Val Ser Asp Leu Glu Tyr Arg Ile Arg
    450                 455                 460                 
Gln Gln Thr Asp Ile Tyr Lys Gln Ile Arg Ala Asn Lys Gly Leu Ile
465                 470                 475                 480 
Val Leu Gly Glu Val Pro Pro Pro Glu His Thr Thr Asp Leu Phe Leu
                485                 490                 495     
Pro Leu Ser Ser Glu Val Lys Thr Asp His Gly Thr Asp Lys Leu Ile
            500                 505                 510         
Glu Ser Val Ser Gln Pro Leu Glu Asn His Gly Ala Pro Ile Ile Gly
        515                 520                 525             
His Ile Ser Glu Ser Leu Ser Thr Lys Ser Cys Gly Ala Leu Arg Pro
    530                 535                 540                 
Val Asn Gly Val Ile Asn Thr Leu Gln Pro Val Leu Ala Asp His Ile
545                 550                 555                 560 
Pro Gly Asp Ser Ser Asp Ala Glu Glu Gln Leu His Lys Lys Gln Arg
                565                 570                 575     
Leu Asn Leu Val Ser Ser Ser Ser Asp Gly Thr Cys Val Ala Ala Arg
            580                 585                 590         
Thr Arg Pro Val Leu Ser Cys Lys Lys Arg Arg Leu Val Arg Pro Asn
        595                 600                 605             
Ser Ile Val Pro Leu Ser Lys Lys Val His Arg Asn Ser Thr Ile Arg
    610                 615                 620                 
Pro Gly Cys Asp Val Asn Pro Ser Cys Ala Leu Cys Gly Ser Gly Ser
625                 630                 635                 640 
Ile Asn Thr Met Pro Pro Glu Ile His Tyr Glu Ala Pro Leu Leu Glu
                645                 650                 655     
Arg Leu Ser Gln Leu Asp Ser Cys Val His Pro Val Leu Ala Phe Pro
            660                 665                 670         
Asp Asp Val Pro Thr Ser Leu His Phe Gln Ser Met Leu Lys Ser Gln
        675                 680                 685             
Trp Gln Asn Lys Pro Phe Asp Lys Ile Lys Pro Pro Lys Lys Leu Ser
    690                 695                 700                 
Leu Lys His Arg Ala Pro Met Pro Gly Ser Leu Pro Asp Ser Ala Arg
705                 710                 715                 720 
Lys Asp Arg His Lys Leu Val Ser Ser Phe Leu Thr Thr Ala Lys Leu
                725                 730                 735     
Ser His His Gln Thr Arg Pro Asp Arg Thr His Arg Gln His Leu Asp
            740                 745                 750         
Asp Val Gly Ala Val Pro Met Val Glu Arg Val Thr Ala Pro Lys Ala
        755                 760                 765             
Glu Arg Leu Leu Asn Pro Pro Pro Pro Val His Asp Pro Asn His Ser
    770                 775                 780                 
Lys Met Arg Leu Arg Asp His Ser Ser Glu Arg Ser Glu Val Leu Lys
785                 790                 795                 800 
His His Thr Asp Met Ser Ser Ser Ser Tyr Leu Ala Ala Thr His His
                805                 810                 815     
Pro Pro His Ser Pro Leu Val Arg Gln Leu Ser Thr Ser Ser Asp Ser
            820                 825                 830         
Pro Ala Pro Ala Ser Ser Ser Ser Gln Val Thr Ala Ser Thr Ser Gln
        835                 840                 845             
Gln Pro Val Arg Arg Arg Arg Gly Glu Ser Ser Phe Asp Ile Asn Asn
    850                 855                 860                 
Ile Val Ile Pro Met Ser Val Ala Ala Thr Thr Arg Val Glu Lys Leu
865                 870                 875                 880 
Gln Tyr Lys Glu Ile Leu Thr Pro Ser Trp Arg Glu Val Asp Leu Gln
                885                 890                 895     
Ser Leu Lys Gly Ser Pro Asp Glu Glu Asn Glu Glu Ile Glu Asp Leu
            900                 905                 910         
Ser Asp Ala Ala Phe Ala Ala Leu His Ala Lys Cys Glu Glu Met Glu
        915                 920                 925             
Arg Ala Arg Trp Leu Trp Thr Thr Ser Val Pro Pro Gln Arg Arg Gly
    930                 935                 940                 
Ser Arg Ser Tyr Arg Ser Ser Asp Gly Arg Thr Thr Pro Gln Leu Gly
945                 950                 955                 960 
Ser Ala Asn Pro Ser Thr Pro Gln Pro Ala Ser Pro Asp Val Ser Ser
                965                 970                 975     
Ser His Ser Leu Ser Glu Tyr Ser His Gly Gln Ser Pro Arg Ser Pro
            980                 985                 990         
Ile Ser Pro Glu Leu His Ser Ala Pro Leu Thr Pro Val Ala Arg Asp
        995                 1000                1005            
Thr Leu Arg His Leu Ala Ser Glu Asp Thr Arg Cys Ser Thr Pro Glu
    1010                1015                1020                
Leu Gly Leu Asp Glu Gln Ser Val Gln Pro Trp Glu Arg Arg Thr Phe
1025                1030                1035                1040
Pro Leu Ala His Ser Pro Gln Ala Glu Cys Glu Asp Gln Leu Asp Ala
                1045                1050                1055    
Gln Glu Arg Ala Ala Arg Cys Thr Arg Arg Thr Ser Gly Ser Lys Thr
            1060                1065                1070        
Gly Arg Glu Thr Glu Ala Ala Pro Thr Ser Pro Pro Ile Val Pro Leu
        1075                1080                1085            
Lys Ser Arg His Leu Val Ala Ala Ala Thr Ala Gln Arg Pro Thr His
    1090                1095                1100                
Arg
1105


<210> 8522
<211> 1105
<212> PRT
<213> Homo sapiens

<400> 8522
Met Ala Ala Met Ala Pro Ala Leu Thr Asp Ala Ala Ala Glu Ala His
 1               5                  10                  15      
His Ile Arg Phe Lys Leu Ala Pro Pro Ser Ser Thr Leu Ser Pro Gly
            20                  25                  30          
Ser Ala Glu Asn Asn Gly Asn Ala Asn Ile Leu Ile Ala Ala Asn Gly
        35                  40                  45              
Thr Lys Arg Lys Ala Ile Ala Ala Glu Asp Pro Ser Leu Asp Phe Arg
    50                  55                  60                  
Asn Asn Pro Thr Lys Glu Asp Leu Gly Lys Leu Gln Pro Leu Val Ala
65                  70                  75                  80  
Ser Tyr Leu Cys Ser Asp Val Thr Ser Val Pro Ser Lys Glu Ser Leu
                85                  90                  95      
Lys Leu Gln Gly Val Phe Ser Lys Gln Thr Val Leu Lys Ser His Pro
            100                 105                 110         
Leu Leu Ser Gln Ser Tyr Glu Leu Arg Ala Glu Leu Leu Gly Arg Gln
        115                 120                 125             
Pro Val Leu Glu Phe Ser Leu Glu Asn Leu Arg Thr Met Asn Thr Ser
    130                 135                 140                 
Gly Gln Thr Ala Leu Pro Gln Ala Pro Val Asn Gly Leu Ala Lys Lys
145                 150                 155                 160 
Leu Thr Lys Ser Ser Thr His Ser Asp His Asp Asn Ser Thr Ser Leu
                165                 170                 175     
Asn Gly Gly Lys Arg Ala Leu Thr Ser Ser Ala Leu His Gly Gly Glu
            180                 185                 190         
Met Gly Gly Ser Glu Ser Gly Asp Leu Lys Gly Gly Met Thr Asn Cys
        195                 200                 205             
Thr Leu Pro His Arg Ser Leu Asp Val Glu His Thr Thr Leu Tyr Ser
    210                 215                 220                 
Asn Asn Ser Thr Ala Asn Lys Ser Ser Val Asn Ser Met Glu Gln Pro
225                 230                 235                 240 
Ala Leu Gln Gly Ser Ser Arg Leu Ser Pro Gly Thr Asp Ser Ser Ser
                245                 250                 255     
Asn Leu Gly Gly Val Lys Leu Glu Gly Lys Lys Ser Pro Leu Ser Ser
            260                 265                 270         
Ile Leu Phe Ser Ala Leu Asp Ser Asp Thr Arg Ile Thr Ala Leu Leu
        275                 280                 285             
Arg Arg Gln Ala Asp Ile Glu Ser Arg Ala Arg Arg Leu Gln Lys Arg
    290                 295                 300                 
Leu Gln Val Val Gln Ala Lys Gln Val Glu Arg His Ile Gln His Gln
305                 310                 315                 320 
Leu Gly Gly Phe Leu Glu Lys Thr Leu Ser Lys Leu Pro Asn Leu Glu
                325                 330                 335     
Ser Leu Arg Pro Arg Ser Gln Leu Met Leu Thr Arg Lys Ala Glu Ala
            340                 345                 350         
Ala Leu Arg Lys Ala Ala Ser Glu Thr Thr Thr Ser Glu Gly Leu Ser
        355                 360                 365             
Asn Phe Leu Lys Ser Asn Ser Ile Ser Glu Glu Leu Glu Arg Phe Thr
    370                 375                 380                 
Ala Ser Gly Ile Ala Asn Leu Arg Cys Ser Glu Gln Ala Phe Asp Ser
385                 390                 395                 400 
Asp Val Thr Asp Ser Ser Ser Gly Gly Glu Ser Asp Ile Glu Glu Glu
                405                 410                 415     
Glu Leu Thr Arg Ala Asp Pro Glu Gln Arg His Val Pro Leu Arg Arg
            420                 425                 430         
Arg Ser Glu Trp Lys Trp Ala Ala Asp Arg Ala Ala Ile Val Ser Arg
        435                 440                 445             
Trp Asn Trp Leu Gln Ala His Val Ser Asp Leu Glu Tyr Arg Ile Arg
    450                 455                 460                 
Gln Gln Thr Asp Ile Tyr Lys Gln Ile Arg Ala Asn Lys Gly Leu Ile
465                 470                 475                 480 
Val Leu Gly Glu Val Pro Pro Pro Glu His Thr Thr Asp Leu Phe Leu
                485                 490                 495     
Pro Leu Ser Ser Glu Val Lys Thr Asp His Gly Thr Asp Lys Leu Ile
            500                 505                 510         
Glu Ser Val Ser Gln Pro Leu Glu Asn His Gly Ala Pro Ile Ile Gly
        515                 520                 525             
His Ile Ser Glu Ser Leu Ser Thr Lys Ser Cys Gly Ala Leu Arg Pro
    530                 535                 540                 
Val Asn Gly Val Ile Asn Thr Leu Gln Pro Val Leu Ala Asp His Ile
545                 550                 555                 560 
Pro Gly Asp Ser Ser Asp Ala Glu Glu Gln Leu His Lys Lys Gln Arg
                565                 570                 575     
Leu Asn Leu Val Ser Ser Ser Ser Asp Gly Thr Cys Val Ala Ala Arg
            580                 585                 590         
Thr Arg Pro Val Leu Ser Cys Lys Lys Arg Arg Leu Val Arg Pro Asn
        595                 600                 605             
Ser Ile Val Pro Leu Ser Lys Lys Val His Arg Asn Ser Thr Ile Arg
    610                 615                 620                 
Pro Gly Cys Asp Val Asn Pro Ser Cys Ala Leu Cys Gly Ser Gly Ser
625                 630                 635                 640 
Ile Asn Thr Met Pro Pro Glu Ile His Tyr Glu Ala Pro Leu Leu Glu
                645                 650                 655     
Arg Leu Ser Gln Leu Asp Ser Cys Val His Pro Val Leu Ala Phe Pro
            660                 665                 670         
Asp Asp Val Pro Thr Ser Leu His Phe Gln Ser Met Leu Lys Ser Gln
        675                 680                 685             
Trp Gln Asn Lys Pro Phe Asp Lys Ile Lys Pro Pro Lys Lys Leu Ser
    690                 695                 700                 
Leu Lys His Arg Ala Pro Met Pro Gly Ser Leu Pro Asp Ser Ala Arg
705                 710                 715                 720 
Lys Asp Arg His Lys Leu Val Ser Ser Phe Leu Thr Thr Ala Lys Leu
                725                 730                 735     
Ser His His Gln Thr Arg Pro Asp Arg Thr His Arg Gln His Leu Asp
            740                 745                 750         
Asp Val Gly Ala Val Pro Met Val Glu Arg Val Thr Ala Pro Lys Ala
        755                 760                 765             
Glu Arg Leu Leu Asn Pro Pro Pro Pro Val His Asp Pro Asn His Ser
    770                 775                 780                 
Lys Met Arg Leu Arg Asp His Ser Ser Glu Arg Ser Glu Val Leu Lys
785                 790                 795                 800 
His His Thr Asp Met Ser Ser Ser Ser Tyr Leu Ala Ala Thr His His
                805                 810                 815     
Pro Pro His Ser Pro Leu Val Arg Gln Leu Ser Thr Ser Ser Asp Ser
            820                 825                 830         
Pro Ala Pro Ala Ser Ser Ser Ser Gln Val Thr Ala Ser Thr Ser Gln
        835                 840                 845             
Gln Pro Val Arg Arg Arg Arg Gly Glu Ser Ser Phe Asp Ile Asn Asn
    850                 855                 860                 
Ile Val Ile Pro Met Ser Val Ala Ala Thr Thr Arg Val Glu Lys Leu
865                 870                 875                 880 
Gln Tyr Lys Glu Ile Leu Thr Pro Ser Trp Arg Glu Val Asp Leu Gln
                885                 890                 895     
Ser Leu Lys Gly Ser Pro Asp Glu Glu Asn Glu Glu Ile Glu Asp Leu
            900                 905                 910         
Ser Asp Ala Ala Phe Ala Ala Leu His Ala Lys Cys Glu Glu Met Glu
        915                 920                 925             
Arg Ala Arg Trp Leu Trp Thr Thr Ser Val Pro Pro Gln Arg Arg Gly
    930                 935                 940                 
Ser Arg Ser Tyr Arg Ser Ser Asp Gly Arg Thr Thr Pro Gln Leu Gly
945                 950                 955                 960 
Ser Ala Asn Pro Ser Thr Pro Gln Pro Ala Ser Pro Asp Val Ser Ser
                965                 970                 975     
Ser His Ser Leu Ser Glu Tyr Ser His Gly Gln Ser Pro Arg Ser Pro
            980                 985                 990         
Ile Ser Pro Glu Leu His Ser Ala Pro Leu Thr Pro Val Ala Arg Asp
        995                 1000                1005            
Thr Pro Arg His Leu Ala Ser Glu Asp Thr Arg Cys Ser Thr Pro Glu
    1010                1015                1020                
Leu Gly Leu Asp Glu Gln Ser Val Gln Pro Trp Glu Arg Arg Thr Phe
1025                1030                1035                1040
Pro Leu Ala His Ser Pro Gln Ala Glu Cys Glu Asp Gln Leu Asp Ala
                1045                1050                1055    
Gln Glu Arg Ala Ala Arg Cys Thr Arg Arg Thr Ser Gly Ser Lys Thr
            1060                1065                1070        
Gly Arg Glu Thr Glu Ala Ala Pro Thr Ser Pro Pro Ile Val Pro Leu
        1075                1080                1085            
Lys Ser Arg His Leu Val Ala Ala Ala Thr Ala Gln Arg Pro Thr His
    1090                1095                1100                
Arg
1105


<210> 8523
<211> 1245
<212> PRT
<213> Homo sapiens

<400> 8523
Met Asn Asn Gln Lys Val Val Ala Val Leu Leu Gln Glu Cys Lys Gln
 1               5                  10                  15      
Val Leu Asp Gln Leu Leu Leu Glu Ala Pro Asp Val Ser Glu Glu Asp
            20                  25                  30          
Lys Ser Glu Asp Gln Arg Cys Arg Ala Leu Leu Pro Ser Glu Leu Arg
        35                  40                  45              
Thr Leu Ile Gln Glu Ala Lys Glu Met Lys Trp Pro Phe Val Pro Glu
    50                  55                  60                  
Lys Trp Gln Tyr Lys Gln Ala Val Gly Pro Glu Asp Lys Thr Asn Leu
65                  70                  75                  80  
Lys Asp Val Ile Gly Ala Gly Leu Gln Gln Leu Leu Ala Ser Leu Arg
                85                  90                  95      
Ala Ser Ile Leu Ala Arg Asp Cys Ala Ala Ala Ala Ala Ile Val Phe
            100                 105                 110         
Leu Val Asp Arg Phe Leu Tyr Gly Leu Asp Val Ser Gly Lys Leu Leu
        115                 120                 125             
Gln Val Ala Lys Gly Leu His Lys Leu Gln Pro Ala Thr Pro Ile Ala
    130                 135                 140                 
Pro Gln Val Val Ile Arg Gln Ala Arg Ile Ser Val Asn Ser Gly Lys
145                 150                 155                 160 
Leu Leu Lys Ala Glu Tyr Ile Leu Ser Ser Leu Ile Ser Asn Asn Gly
                165                 170                 175     
Ala Thr Gly Thr Trp Leu Tyr Arg Asn Glu Ser Asp Lys Val Leu Val
            180                 185                 190         
Gln Ser Val Cys Ile Gln Ile Arg Gly Gln Ile Leu Gln Lys Leu Gly
        195                 200                 205             
Met Trp Tyr Glu Ala Ala Glu Leu Ile Trp Ala Ser Ile Val Gly Tyr
    210                 215                 220                 
Leu Ala Leu Pro Gln Pro Asp Lys Lys Val Gly Leu Ser Thr Ser Leu
225                 230                 235                 240 
Gly Ile Leu Ala Asp Ile Phe Val Ser Met Ser Lys Asn Asp Tyr Glu
                245                 250                 255     
Lys Phe Lys Asn Asn Pro Gln Ile Asn Leu Ser Leu Leu Lys Glu Phe
            260                 265                 270         
Asp His His Leu Leu Ser Ala Ala Glu Ala Cys Lys Leu Ala Ala Ala
        275                 280                 285             
Phe Ser Ala Tyr Thr Pro Leu Phe Val Leu Thr Ala Val Asn Ile Arg
    290                 295                 300                 
Gly Thr Cys Leu Leu Ser Tyr Ser Ser Ser Asn Asp Cys Pro Pro Glu
305                 310                 315                 320 
Leu Lys Asn Leu His Leu Cys Glu Ala Lys Glu Ala Phe Glu Ile Gly
                325                 330                 335     
Leu Leu Thr Lys Arg Asp Asp Glu Pro Val Thr Gly Lys Gln Glu Leu
            340                 345                 350         
His Ser Phe Val Lys Ala Ala Phe Gly Leu Thr Thr Val His Arg Arg
        355                 360                 365             
Leu His Gly Glu Thr Gly Thr Val His Ala Ala Ser Gln Leu Cys Lys
    370                 375                 380                 
Glu Ala Met Gly Lys Leu Tyr Asn Phe Ser Thr Ser Ser Arg Ser Gln
385                 390                 395                 400 
Asp Arg Glu Ala Leu Ser Gln Glu Val Met Ser Val Ile Ala Gln Val
                405                 410                 415     
Lys Glu His Leu Gln Val Gln Ser Phe Ser Asn Val Asp Asp Arg Ser
            420                 425                 430         
Tyr Val Pro Glu Ser Phe Glu Cys Arg Leu Asp Lys Leu Ile Leu His
        435                 440                 445             
Gly Gln Gly Asp Phe Gln Lys Ile Leu Asp Thr Tyr Ser Gln His His
    450                 455                 460                 
Thr Ser Val Cys Glu Val Phe Glu Ser Asp Cys Gly Asn Asn Lys Asn
465                 470                 475                 480 
Glu Gln Lys Asp Ala Lys Thr Gly Val Cys Ile Thr Ala Leu Lys Thr
                485                 490                 495     
Glu Ile Lys Asn Ile Asp Thr Val Ser Thr Thr Gln Glu Lys Pro His
            500                 505                 510         
Cys Gln Arg Asp Thr Gly Ile Ser Ser Ser Leu Met Gly Lys Asn Val
        515                 520                 525             
Gln Arg Glu Leu Arg Arg Gly Gly Arg Arg Asn Trp Thr His Ser Asp
    530                 535                 540                 
Ala Phe Arg Val Ser Leu Asp Gln Asp Val Glu Thr Glu Thr Glu Pro
545                 550                 555                 560 
Ser Asp Tyr Ser Asn Gly Glu Gly Ala Val Phe Asn Lys Ser Leu Ser
                565                 570                 575     
Gly Ser Gln Thr Ser Ser Ala Trp Ser Asn Leu Ser Gly Phe Ser Ser
            580                 585                 590         
Ser Ala Ser Trp Glu Glu Val Asn Tyr His Val Asp Asp Arg Ser Ala
        595                 600                 605             
Arg Lys Glu Pro Gly Lys Glu His Leu Val Asp Thr Gln Cys Ser Thr
    610                 615                 620                 
Ala Leu Ser Glu Glu Leu Glu Asn Asp Arg Glu Gly Arg Ala Met His
625                 630                 635                 640 
Ser Leu His Ser Gln Leu His Asp Leu Ser Leu Gln Glu Pro Asn Asn
                645                 650                 655     
Asp Asn Leu Glu Pro Ser Gln Asn Gln Pro Gln Gln Gln Met Pro Leu
            660                 665                 670         
Thr Pro Phe Ser Pro His Asn Thr Pro Gly Ile Phe Leu Ala Pro Gly
        675                 680                 685             
Ala Gly Leu Leu Glu Gly Ala Pro Glu Gly Ile Gln Glu Val Arg Asn
    690                 695                 700                 
Met Gly Pro Arg Asn Thr Ser Ala His Ser Arg Pro Ser Tyr Arg Ser
705                 710                 715                 720 
Ala Ser Trp Ser Ser Asp Ser Gly Arg Pro Lys Asn Met Gly Thr His
                725                 730                 735     
Pro Ser Val Gln Lys Glu Glu Ala Phe Glu Ile Ile Val Glu Phe Pro
            740                 745                 750         
Glu Thr Asn Cys Asp Val Lys Asp Arg Gln Gly Lys Glu Gln Gly Glu
        755                 760                 765             
Glu Ile Ser Glu Arg Gly Ala Gly Pro Thr Phe Lys Ala Ser Pro Ser
    770                 775                 780                 
Trp Val Asp Pro Glu Gly Glu Thr Ala Glu Ser Thr Glu Asp Ala Pro
785                 790                 795                 800 
Leu Asp Phe His Arg Val Leu His Asn Ser Leu Gly Asn Ile Ser Met
                805                 810                 815     
Leu Pro Cys Ser Ser Phe Thr Pro Asn Trp Pro Val Gln Asn Pro Asp
            820                 825                 830         
Ser Arg Lys Ser Gly Gly Pro Val Ala Glu Gln Gly Ile Asp Pro Asp
        835                 840                 845             
Ala Ser Thr Val Asp Glu Glu Gly Gln Leu Leu Asp Ser Met Asp Val
    850                 855                 860                 
Pro Cys Thr Asn Gly His Gly Ser His Arg Leu Cys Ile Leu Arg Gln
865                 870                 875                 880 
Pro Pro Gly Gln Arg Ala Glu Thr Pro Asn Ser Ser Val Ser Gly Asn
                885                 890                 895     
Ile Leu Phe Pro Val Leu Ser Glu Asp Cys Thr Thr Thr Glu Glu Gly
            900                 905                 910         
Asn Gln Pro Gly Asn Met Leu Asn Cys Ser Gln Asn Ser Ser Ser Ser
        915                 920                 925             
Ser Val Trp Trp Leu Lys Ser Pro Ala Phe Ser Ser Gly Ser Ser Glu
    930                 935                 940                 
Gly Asp Ser Pro Trp Ser Tyr Leu Asn Ser Ser Gly Ser Ser Trp Val
945                 950                 955                 960 
Ser Leu Pro Gly Lys Met Arg Lys Glu Ile Leu Glu Ala Arg Thr Leu
                965                 970                 975     
Gln Pro Asp Asp Phe Glu Lys Leu Leu Ala Gly Val Arg His Asp Trp
            980                 985                 990         
Leu Phe Gln Arg Leu Glu Asn Thr Gly Val Phe Lys Pro Ser Gln Leu
        995                 1000                1005            
His Arg Ala His Ser Ala Leu Leu Leu Lys Tyr Ser Lys Lys Ser Glu
    1010                1015                1020                
Leu Trp Thr Ala Gln Glu Thr Ile Val Tyr Leu Gly Asp Tyr Leu Thr
1025                1030                1035                1040
Val Lys Lys Lys Gly Arg Gln Arg Asn Ala Phe Trp Val His His Leu
                1045                1050                1055    
His Gln Glu Glu Ile Leu Gly Arg Tyr Val Gly Lys Asp Tyr Lys Glu
            1060                1065                1070        
Gln Lys Gly Leu Trp His His Phe Thr Asp Val Glu Arg Gln Met Thr
        1075                1080                1085            
Ala Gln His Tyr Val Thr Glu Phe Asn Lys Arg Leu Tyr Glu Gln Asn
    1090                1095                1100                
Ile Pro Thr Gln Ile Phe Tyr Ile Pro Ser Thr Ile Leu Leu Ile Leu
1105                1110                1115                1120
Glu Asp Lys Thr Ile Lys Gly Cys Ile Ser Val Glu Pro Tyr Ile Leu
                1125                1130                1135    
Gly Glu Phe Val Lys Leu Ser Asn Asn Thr Lys Val Val Lys Thr Glu
            1140                1145                1150        
Tyr Lys Ala Thr Glu Tyr Gly Leu Ala Tyr Gly His Phe Ser Tyr Glu
        1155                1160                1165            
Phe Ser Asn His Arg Asp Val Val Val Asp Leu Gln Gly Trp Val Thr
    1170                1175                1180                
Gly Asn Gly Lys Gly Leu Ile Tyr Leu Thr Asp Pro Gln Ile His Ser
1185                1190                1195                1200
Val Asp Gln Lys Val Phe Thr Thr Asn Phe Gly Lys Arg Gly Ile Phe
                1205                1210                1215    
Tyr Phe Phe Asn Asn Gln His Val Glu Cys Asn Glu Ile Cys His Arg
            1220                1225                1230        
Leu Ser Leu Thr Arg Pro Ser Met Glu Lys Pro Cys Thr
        1235                1240                1245


<210> 8524
<211> 1568
<212> PRT
<213> Homo sapiens

<400> 8524
Glu Ala Gly Glu Gly Ile Leu Ser Glu Arg Arg Phe Glu Asp Ser Val
 1               5                  10                  15      
Ile Val Arg Thr Met Lys Pro His Ala Glu Leu Glu Gly Ser Arg Arg
            20                  25                  30          
Phe Leu His His Arg Gly Glu Pro Arg Leu Leu Glu Lys His Ala Gln
        35                  40                  45              
Gly Arg Pro Arg Phe Asp Trp Leu Gln Asp Glu Asp Glu Gln Gly Ser
    50                  55                  60                  
Pro Gln Asp Ala Gly Leu His Leu Asp Leu Pro Ala Gln Pro Pro Pro
65                  70                  75                  80  
Leu Ala Pro Phe Arg Arg Val Phe Val Pro Val Glu Asp Thr Pro Lys
                85                  90                  95      
Thr Leu Asp Met Ala Val Val Gly Gly Arg Glu Asp Leu Glu Asp Leu
            100                 105                 110         
Glu Gly Leu Ala Gln Pro Ser Glu Trp Gly Leu Pro Thr Ser Ala Ser
        115                 120                 125             
Glu Val Ala Thr Gln Thr Trp Thr Val Asn Ser Glu Ala Ser Val Glu
    130                 135                 140                 
Arg Leu Gln Pro Leu Leu Pro Pro Ile Arg Thr Gly Pro Tyr Leu Cys
145                 150                 155                 160 
Glu Leu Leu Glu Glu Val Ala Glu Gly Val Ala Ser Pro Asp Glu Asp
                165                 170                 175     
Glu Asp Glu Glu Pro Ala Val Phe Pro Cys Ile Glu Cys Ser Ile Tyr
            180                 185                 190         
Phe Lys Gln Lys Glu His Leu Leu Glu His Met Ser Gln His Arg Arg
        195                 200                 205             
Ala Pro Gly Gln Glu Pro Pro Ala Asp Leu Ala Pro Leu Ala Cys Gly
    210                 215                 220                 
Glu Cys Gly Trp Ala Phe Ala Asp Pro Thr Ala Leu Glu Gln His Arg
225                 230                 235                 240 
Gln Leu His Gln Ala Ser Arg Glu Lys Ile Ile Glu Glu Ile Gln Lys
                245                 250                 255     
Leu Lys Gln Val Pro Gly Asp Glu Gly Arg Glu Ala Arg Leu Gln Cys
            260                 265                 270         
Pro Lys Cys Val Phe Gly Thr Asn Ser Ser Arg Ala Tyr Val Gln His
        275                 280                 285             
Ala Lys Leu His Met Arg Glu Pro Pro Gly Gln Thr Thr Lys Glu Pro
    290                 295                 300                 
Phe Gly Gly Ser Ser Gly Ala Gly Ser Pro Ser Pro Glu Ala Ser Ala
305                 310                 315                 320 
Leu Leu Tyr Gln Pro Tyr Gly Ala Ala Val Gly Leu Ser Ala Cys Val
                325                 330                 335     
Phe Cys Gly Phe Pro Ala Pro Ser Glu Ser Leu Leu Arg Glu His Val
            340                 345                 350         
Arg Leu Val His Ala His Pro His Trp Glu Glu Asp Gly Glu Ala Tyr
        355                 360                 365             
Glu Glu Asp Pro Ala Ser Gln Pro Gly Thr Ser Gln Asp Ala His Ala
    370                 375                 380                 
Cys Phe Pro Asp Thr Ala Val Asp Tyr Phe Gly Lys Ala Glu Pro Ser
385                 390                 395                 400 
Leu Ala Pro Met Trp Arg Glu Asn Pro Ala Gly Tyr Asp Pro Ser Leu
                405                 410                 415     
Ala Phe Gly Pro Gly Cys Gln Gln Leu Ser Ile Arg Asp Phe Pro Leu
            420                 425                 430         
Ser Lys Pro Leu Leu His Gly Thr Gly Gln Arg Pro Leu Gly Arg Leu
        435                 440                 445             
Ala Phe Pro Ser Thr Leu Ala Ser Thr Pro Tyr Ser Leu Gln Leu Gly
    450                 455                 460                 
Arg Asn Lys Ser Thr Val His Pro Gln Gly Leu Gly Glu Arg Arg Arg
465                 470                 475                 480 
Pro Trp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Val Val
                485                 490                 495     
Leu Thr Ser Glu Met Asp Phe Ser Pro Glu Asn Gly Val Phe Ser Pro
            500                 505                 510         
Leu Ala Thr Pro Ser Leu Ile Pro Gln Ala Ala Leu Glu Leu Lys Gln
        515                 520                 525             
Ala Phe Arg Glu Ala Leu Gln Ala Val Glu Ala Thr Gln Gly Gln Gln
    530                 535                 540                 
Gln Gln Leu Arg Gly Met Val Pro Ile Val Leu Val Ala Lys Leu Gly
545                 550                 555                 560 
Pro Gln Val Met Ala Ala Ala Arg Val Pro Pro Arg Leu Gln Pro Glu
                565                 570                 575     
Glu Leu Gly Leu Ala Gly Ala His Pro Leu Asp Phe Leu Leu Leu Asp
            580                 585                 590         
Ala Pro Leu Gly Gly Pro Leu Gly Leu Asp Thr Leu Leu Asp Gly Asp
        595                 600                 605             
Pro Ala Met Ala Leu Lys His Glu Glu Arg Lys Cys Pro Tyr Cys Pro
    610                 615                 620                 
Asp Arg Phe His Asn Gly Ile Gly Leu Ala Asn His Val Arg Gly His
625                 630                 635                 640 
Leu Asn Arg Val Gly Val Ser Tyr Asn Val Arg His Phe Ile Ser Ala
                645                 650                 655     
Glu Glu Val Lys Ala Ile Glu Arg Arg Phe Ser Phe Gln Lys Lys Lys
            660                 665                 670         
Lys Lys Val Ala Asn Phe Asp Pro Gly Thr Phe Ser Leu Met Arg Cys
        675                 680                 685             
Asp Phe Cys Gly Ala Gly Phe Asp Thr Arg Ala Gly Leu Ser Ser His
    690                 695                 700                 
Ala Arg Ala His Leu Arg Asp Phe Gly Ile Thr Asn Trp Glu Leu Thr
705                 710                 715                 720 
Val Ser Pro Ile Asn Ile Leu Gln Glu Leu Leu Ala Thr Ser Ala Ala
                725                 730                 735     
Glu Gln Pro Pro Ser Pro Leu Gly Arg Glu Pro Gly Gly Pro Pro Gly
            740                 745                 750         
Ser Phe Leu Thr Ser Arg Arg Pro Arg Leu Pro Leu Thr Val Pro Phe
        755                 760                 765             
Pro Pro Thr Trp Ala Glu Asp Pro Gly Pro Ala Tyr Gly Asp Ala Gln
    770                 775                 780                 
Ser Leu Thr Thr Cys Glu Val Cys Gly Ala Cys Phe Glu Thr Arg Lys
785                 790                 795                 800 
Gly Leu Ser Ser His Ala Arg Ser His Leu Arg Gln Leu Gly Val Ala
                805                 810                 815     
Glu Ser Glu Ser Ser Gly Ala Pro Ile Asp Leu Leu Tyr Glu Leu Val
            820                 825                 830         
Lys Gln Lys Gly Leu Pro Asp Ala His Leu Gly Leu Pro Pro Gly Leu
        835                 840                 845             
Ala Lys Lys Ser Ser Ser Leu Lys Glu Val Val Ala Gly Ala Pro Arg
    850                 855                 860                 
Pro Gly Leu Leu Ser Leu Ala Lys Pro Leu Asp Ala Pro Ala Val Asn
865                 870                 875                 880 
Lys Ala Ile Lys Ser Pro Pro Gly Phe Ser Ala Lys Gly Leu Gly His
                885                 890                 895     
Pro Pro Ser Ser Pro Leu Leu Lys Lys Thr Pro Leu Ala Leu Ala Gly
            900                 905                 910         
Ser Pro Thr Pro Lys Asn Pro Glu Asp Lys Ser Pro Gln Leu Ser Leu
        915                 920                 925             
Ser Pro Arg Pro Ala Ser Pro Lys Ala Gln Trp Pro Gln Ser Glu Asp
    930                 935                 940                 
Glu Gly Pro Leu Asn Leu Thr Ser Gly Pro Glu Pro Ala Arg Asp Ile
945                 950                 955                 960 
Arg Cys Glu Phe Cys Gly Glu Phe Phe Glu Asn Arg Lys Gly Leu Ser
                965                 970                 975     
Ser His Ala Arg Ser His Leu Arg Gln Met Gly Val Thr Glu Trp Tyr
            980                 985                 990         
Val Asn Gly Ser Pro Ile Asp Thr Leu Arg Glu Ile Leu Lys Arg Arg
        995                 1000                1005            
Thr Gln Ser Arg Pro Gly Gly Pro Pro Asn Pro Pro Gly Pro Ser Pro
    1010                1015                1020                
Lys Ala Leu Ala Lys Met Met Gly Gly Ala Gly Pro Gly Ser Ser Leu
1025                1030                1035                1040
Glu Ala Arg Ser Pro Ser Asp Leu His Ile Ser Pro Leu Ala Lys Lys
                1045                1050                1055    
Leu Pro Pro Pro Pro Gly Ser Pro Leu Gly His Ser Pro Thr Ala Ser
            1060                1065                1070        
Pro Pro Pro Thr Ala Arg Lys Met Phe Pro Gly Leu Ala Ala Pro Ser
        1075                1080                1085            
Leu Pro Lys Lys Leu Lys Pro Glu Gln Ile Arg Val Glu Ile Lys Arg
    1090                1095                1100                
Glu Met Leu Pro Gly Ala Leu His Gly Glu Leu His Pro Ser Glu Gly
1105                1110                1115                1120
Pro Trp Gly Ala Pro Arg Glu Asp Met Thr Pro Leu Asn Leu Ser Ser
                1125                1130                1135    
Arg Ala Glu Pro Val Arg Asp Ile Arg Cys Glu Phe Cys Gly Glu Phe
            1140                1145                1150        
Phe Glu Asn Arg Lys Gly Leu Ser Ser His Ala Arg Ser His Leu Arg
        1155                1160                1165            
Gln Met Gly Val Thr Glu Trp Ser Val Asn Gly Ser Pro Ile Asp Thr
    1170                1175                1180                
Leu Arg Glu Ile Leu Lys Lys Lys Ser Lys Pro Cys Leu Ile Lys Lys
1185                1190                1195                1200
Glu Pro Pro Ala Gly Asp Leu Ala Pro Ala Leu Ala Glu Asp Gly Pro
                1205                1210                1215    
Pro Thr Val Ala Pro Gly Pro Val Gln Ser Pro Leu Pro Leu Ser Pro
            1220                1225                1230        
Leu Ala Gly Arg Pro Gly Lys Pro Gly Ala Gly Pro Ala Gln Val Pro
        1235                1240                1245            
Arg Glu Leu Ser Leu Thr Pro Ile Thr Gly Ala Lys Pro Ser Ala Thr
    1250                1255                1260                
Gly Tyr Leu Gly Ser Val Ala Ala Lys Arg Pro Leu Gln Glu Asp Arg
1265                1270                1275                1280
Leu Leu Pro Ala Glu Val Lys Ala Lys Thr Tyr Ile Gln Thr Glu Leu
                1285                1290                1295    
Pro Phe Lys Ala Lys Thr Leu His Glu Lys Thr Ser His Ser Ser Thr
            1300                1305                1310        
Glu Ala Cys Cys Glu Leu Cys Gly Leu Tyr Phe Glu Asn Arg Lys Ala
        1315                1320                1325            
Leu Ala Ser His Ala Arg Ala His Leu Arg Gln Phe Gly Val Thr Glu
    1330                1335                1340                
Trp Cys Val Asn Gly Ser Pro Ile Glu Thr Leu Ser Glu Trp Ile Lys
1345                1350                1355                1360
His Arg Pro Gln Lys Val Gly Ala Tyr Arg Ser Tyr Ile Gln Gly Gly
                1365                1370                1375    
Arg Pro Phe Thr Lys Lys Phe Arg Ser Ala Gly His Gly Arg Asp Ser
            1380                1385                1390        
Asp Lys Arg Pro Ser Leu Gly Leu Ala Pro Gly Gly Leu Ala Val Val
        1395                1400                1405            
Gly Arg Ser Ala Gly Gly Glu Pro Gly Pro Glu Ala Gly Arg Ala Ala
    1410                1415                1420                
Asp Gly Gly Glu Arg Pro Leu Ala Ala Ser Pro Pro Gly Thr Val Lys
1425                1430                1435                1440
Ala Glu Glu His Gln Arg Gln Asn Ile Asn Lys Phe Glu Arg Arg Gln
                1445                1450                1455    
Ala Arg Pro Pro Asp Ala Ser Ala Ala Arg Gly Gly Glu Asp Thr Asn
            1460                1465                1470        
Asp Leu Gln Gln Lys Leu Glu Glu Val Arg Gln Pro Pro Pro Arg Val
        1475                1480                1485            
Arg Pro Val Pro Ser Leu Val Pro Arg Pro Pro Gln Thr Ser Leu Val
    1490                1495                1500                
Lys Phe Val Gly Asn Ile Tyr Thr Leu Lys Cys Arg Phe Cys Glu Val
1505                1510                1515                1520
Glu Phe Gln Gly Pro Leu Ser Ile Gln Glu Glu Trp Val Arg His Leu
                1525                1530                1535    
Gln Arg His Ile Leu Glu Met Asn Phe Ser Lys Ala Asp Pro Pro Pro
            1540                1545                1550        
Glu Glu Ser Gln Ala Pro Gln Ala Gln Thr Ala Ala Ala Glu Ala Pro
        1555                1560                1565            


<210> 8525
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8525
Asp Thr Leu Phe Cys Lys Tyr Gln Leu Pro Ala Pro Pro Glu Ser Ser
 1               5                  10                  15      
Ser Ile Leu Tyr Lys Val Phe Ala Val Thr Arg Asp Gly Arg Ile Leu
            20                  25                  30          
Ala Ala Gly Gly Lys Ser Asn His Leu His Leu Trp Cys Leu Glu Ala
        35                  40                  45              
Arg Gln Leu Phe Arg Ile Ile Gln Met Pro Thr Lys Val Arg Ala Ile
    50                  55                  60                  
Arg His Leu Glu Phe Leu Pro Asp Ser Phe Asp Ala Gly Ser Asn Gln
65                  70                  75                  80  
Val Leu Gly Val Leu Ser Gln Asp Gly Ile Met Arg Phe Ile Asn Met
                85                  90                  95      
Gln Thr Cys Lys Leu Leu Phe Glu Ile Gly Ser Leu Asp Glu Gly Ile
            100                 105                 110         
Ser Ser Ser Ala Ile Ser Pro His Gly Arg Tyr Ile Ala Ser Ile Met
        115                 120                 125             
Glu Asn Gly Ser Leu Asn Ile Tyr Ser Val Gln Ala Leu Thr Gln Glu
    130                 135                 140                 
Ile Asn Lys Glu Glu Val Arg Ala Gln Asn
145                 150                 


<210> 8526
<211> 211
<212> PRT
<213> Homo sapiens

<400> 8526
Met Lys Ile Trp Thr Ser Glu His Val Phe Asp His Pro Trp Glu Thr
 1               5                  10                  15      
Val Thr Thr Ala Ala Met Gln Lys Tyr Pro Asn Pro Met Asn Pro Ser
            20                  25                  30          
Val Val Gly Val Asp Val Leu Asp Arg His Ile Asp Pro Ser Gly Lys
        35                  40                  45              
Leu His Ser His Arg Leu Leu Ser Thr Glu Trp Gly Leu Pro Ser Ile
    50                  55                  60                  
Val Lys Ser Leu Ile Gly Ala Ala Arg Thr Lys Thr Tyr Val Gln Glu
65                  70                  75                  80  
His Ser Val Val Asp Pro Val Glu Lys Thr Met Glu Leu Lys Ser Thr
                85                  90                  95      
Asn Ile Ser Phe Thr Asn Met Val Ser Val Asp Glu Arg Leu Ile Tyr
            100                 105                 110         
Lys Pro His Pro Gln Asp Pro Glu Lys Thr Val Leu Thr Gln Glu Ala
        115                 120                 125             
Ile Ile Thr Val Lys Gly Val Ser Leu Ser Ser Tyr Leu Glu Gly Leu
    130                 135                 140                 
Met Ala Ser Thr Ile Ser Ser Asn Ala Ser Lys Gly Arg Glu Ala Met
145                 150                 155                 160 
Glu Trp Val Ile His Lys Leu Asn Ala Glu Ile Glu Glu Leu Thr Ala
                165                 170                 175     
Ser Ala Arg Gly Thr Ile Arg Thr Pro Met Ala Ala Ala Ala Phe Cys
            180                 185                 190         
Arg Glu Val Ile Val Thr Val Gly Arg Gln His Arg Val Leu Gln Val
        195                 200                 205             
Ser Pro Asn
    210     


<210> 8527
<211> 194
<212> PRT
<213> Homo sapiens

<400> 8527
Met Lys Ile Trp Thr Ser Glu His Val Phe Asp His Pro Trp Glu Thr
 1               5                  10                  15      
Val Thr Thr Ala Ala Met Gln Lys Tyr Pro Asn Pro Met Asn Pro Ser
            20                  25                  30          
Val Val Gly Val Asp Val Leu Asp Arg His Ile Asp Pro Ser Gly Lys
        35                  40                  45              
Leu His Ser His Arg Leu Leu Ser Thr Glu Trp Gly Leu Pro Ser Ile
    50                  55                  60                  
Val Lys Ser Leu Ile Gly Ala Ala Arg Thr Lys Thr Tyr Val Gln Glu
65                  70                  75                  80  
His Ser Val Val Asp Pro Val Glu Lys Thr Met Glu Leu Lys Ser Thr
                85                  90                  95      
Asn Ile Ser Phe Thr Asn Met Val Ser Val Asp Glu Arg Leu Ile Tyr
            100                 105                 110         
Lys Pro His Pro Gln Asp Pro Glu Lys Thr Val Leu Thr Gln Glu Ala
        115                 120                 125             
Ile Ile Thr Val Lys Gly Val Ser Leu Ser Ser Tyr Leu Glu Gly Leu
    130                 135                 140                 
Met Ala Ser Thr Ile Ser Ser Asn Ala Ser Lys Gly Arg Glu Ala Met
145                 150                 155                 160 
Glu Trp Val Ile His Lys Leu Asn Ala Glu Ile Glu Glu Leu Thr Ala
                165                 170                 175     
Ser Ala Arg Gly Thr Ile Arg Thr Pro Met Ala Ala Ala Ala Phe Ala
            180                 185                 190         
Glu Lys
        


<210> 8528
<211> 301
<212> PRT
<213> Homo sapiens

<400> 8528
Ser Lys Ser Glu Ser Pro Lys Gly Pro Glu Gln Leu Arg Lys Leu Ile
 1               5                  10                  15      
Gly Gly Leu Ser Leu Glu Thr Thr Asp Glu Ser Pro Arg Ile His Ser
            20                  25                  30          
Glu Gln Trp Gly Met Leu Thr Asp Cys Val Ile Met Arg Asp Pro Asn
        35                  40                  45              
Thr Lys His Ser Arg Gly Phe Gly Phe Val Ser Tyr Ala Thr Val Glu
    50                  55                  60                  
Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp Glu Glu
65                  70                  75                  80  
Leu Trp Asn Gln Arg Glu Leu Ser Glu Asp Ser Gln Arg Pro Gly Ala
                85                  90                  95      
His Ser Thr Val Lys Lys Thr Phe Val Ala Gly Ile Lys Glu Asp Thr
            100                 105                 110         
Glu Glu His His Leu Arg Asp Tyr Phe Gln Gln Tyr Arg Lys Ile Glu
        115                 120                 125             
Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Phe Val Asp
    130                 135                 140                 
Lys Thr Val Ile Gln Lys His His Thr Val Asn Gly His Asn Cys Glu
145                 150                 155                 160 
Val Arg Lys Ala Leu Ser Asn Gln Glu Met Ala Ser Ala Ser Ser Ser
                165                 170                 175     
Gln Arg Gly Gln Ser Gly Ser Gly Asn Phe Gly Pro Gly Tyr Ser Gly
            180                 185                 190         
Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln Gly Tyr Gly Asn Gln Gly
        195                 200                 205             
Ser Gly Tyr Gly Arg Ser Asp Ser Tyr Asp Ser Tyr Asn Asn Gly Gly
    210                 215                 220                 
Arg Gly Gly Phe Gly Gly Gly Ser Gly Ser Asn Phe Gly Gly Gly Gly
225                 230                 235                 240 
Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Ser Ser Asn Phe Gly Thr
                245                 250                 255     
Met Lys Val Gly Asn Phe Gly Gly Arg Asn Ser Gly Ser Tyr Gly Val
            260                 265                 270         
Gly Gly Gln Tyr Phe Ala Lys Pro Arg His Gln Gly Gly Tyr Gly Gly
        275                 280                 285             
Ser Ser Ser Ser Gly Ser Tyr Asp Ser Gly Arg Arg Phe
    290                 295                 300     


<210> 8529
<211> 2651
<212> PRT
<213> Homo sapiens

<400> 8529
Leu Gln His Arg Pro Pro Gly Phe Ser Arg Leu Lys Met Ser Ser Ser
 1               5                  10                  15      
His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala Pro Gly Gly Gly
            20                  25                  30          
Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu Lys Asp Leu Ala
        35                  40                  45              
Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr Phe Thr Arg Trp
    50                  55                  60                  
Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile Ala Asn Leu Gln
65                  70                  75                  80  
Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu Leu Glu Val Leu
                85                  90                  95      
Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg Pro Thr Phe Arg
            100                 105                 110         
Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu Phe Leu Asp Arg
        115                 120                 125             
Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala Ile Val Asp Gly
    130                 135                 140                 
Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu Ile Leu His Tyr
145                 150                 155                 160 
Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp Glu Glu Ala Lys
                165                 170                 175     
Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile Gln Asn Lys Leu
            180                 185                 190         
Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp Gln Ser Gly Arg
        195                 200                 205             
Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly Leu Cys Pro Asp
    210                 215                 220                 
Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn Ala Arg Glu Ala
225                 230                 235                 240 
Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln Val Ile Thr Pro
                245                 250                 255     
Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser Val Met Thr Tyr
            260                 265                 270         
Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly Ala Pro Leu Arg
        275                 280                 285             
Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly Pro Gly Ile Glu
    290                 295                 300                 
Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe Thr Val Glu Thr
305                 310                 315                 320 
Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val Glu Asp Pro Ala
                325                 330                 335     
Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn Asp Lys Asn Arg
            340                 345                 350         
Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly Thr His Lys Val
        355                 360                 365             
Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser Pro Phe Glu Val
    370                 375                 380                 
Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val Thr Ala Gln Gly
385                 390                 395                 400 
Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys Thr Thr Tyr Phe
                405                 410                 415     
Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val Glu Val Val Ile
            420                 425                 430         
Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro Gln Leu Glu Ala
        435                 440                 445             
Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro Thr Met Glu Gly
    450                 455                 460                 
Val His Thr Val His Val Thr Phe Ala Gly Val Pro Ile Pro Arg Ser
465                 470                 475                 480 
Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro Ser Ala Cys Arg
                485                 490                 495     
Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg Val Lys Glu Thr
            500                 505                 510         
Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser Gly Glu Leu Lys
        515                 520                 525             
Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val Lys Gln Lys Asp
    530                 535                 540                 
Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro Met Val Pro Gly
545                 550                 555                 560 
Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn Ile Gly Arg Ser
                565                 570                 575     
Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn Gln Lys Val Arg
            580                 585                 590         
Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly Lys Ser Ala Asp
        595                 600                 605             
Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr Leu Gly Phe Ser
    610                 615                 620                 
Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp Asp Lys Gly Asp
625                 630                 635                 640 
Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala Gly Glu Tyr Ala
                645                 650                 655     
Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu Ser Pro Phe Met
            660                 665                 670         
Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro Asp Arg Val Lys
        675                 680                 685             
Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala Val Asn Lys Pro
    690                 695                 700                 
Ala Glu Leu Thr Val Asp Ala Lys His Gly Gly Lys Ala Pro Leu Arg
705                 710                 715                 720 
Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu Ala Leu Val Lys
                725                 730                 735     
Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val Pro Arg Lys Pro
            740                 745                 750         
Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val Ser Ile Pro Asn
        755                 760                 765             
Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His Pro Asn Lys Val
    770                 775                 780                 
Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu Lys Ala His Glu
785                 790                 795                 800 
Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly Gln Gly Asp Val
                805                 810                 815     
Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly Pro Ala Glu Ala
            820                 825                 830         
Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp Thr Phe Thr Val
        835                 840                 845             
Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile Met Val Leu Phe
    850                 855                 860                 
Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val Lys Val Glu Pro
865                 870                 875                 880 
Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro Gly Leu Ser Arg
                885                 890                 895     
Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr Val Asn Ala Lys
            900                 905                 910         
Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser Gly Leu Thr Lys
        915                 920                 925             
Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His His Asp Asn Thr
    930                 935                 940                 
Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro Val Gly Val Asn
945                 950                 955                 960 
Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro Phe Ser Val Ala
                965                 970                 975     
Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val Ser Gly Leu Gly
            980                 985                 990         
Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr Val Lys Ser Lys
        995                 1000                1005            
Gly Ala Gly Gly Gln Gly Lys Val Ala Ser Lys Ile Val Gly Pro Ser
    1010                1015                1020                
Gly Ala Ala Val Pro Cys Lys Val Glu Pro Gly Leu Gly Ala Asp Asn
1025                1030                1035                1040
Ser Val Val Arg Phe Leu Pro Arg Glu Glu Gly Pro Tyr Glu Val Glu
                1045                1050                1055    
Val Thr Tyr Asp Gly Val Pro Val Pro Gly Ser Pro Phe Pro Leu Glu
            1060                1065                1070        
Ala Val Ala Pro Thr Lys Pro Ser Lys Val Lys Ala Phe Gly Pro Gly
        1075                1080                1085            
Leu Gln Gly Gly Ser Ala Gly Ser Pro Ala Arg Phe Thr Ile Asp Thr
    1090                1095                1100                
Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val Glu Gly Pro Cys
1105                1110                1115                1120
Glu Ala Gln Leu Glu Cys Leu Asp Asn Gly Asp Gly Thr Cys Ser Val
                1125                1130                1135    
Ser Tyr Val Pro Thr Glu Pro Gly Asp Tyr Asn Ile Asn Ile Leu Phe
            1140                1145                1150        
Ala Asp Thr His Ile Pro Gly Ser Pro Phe Lys Ala His Val Val Pro
        1155                1160                1165            
Cys Phe Asp Ala Ser Lys Val Lys Cys Ser Gly Pro Gly Leu Glu Arg
    1170                1175                1180                
Ala Thr Ala Gly Glu Val Gly Gln Phe Gln Val Asp Cys Ser Ser Ala
1185                1190                1195                1200
Gly Ser Ala Glu Leu Thr Ile Glu Ile Cys Ser Glu Ala Gly Leu Pro
                1205                1210                1215    
Ala Glu Val Tyr Ile Gln Asp His Gly Asp Gly Thr His Thr Ile Thr
            1220                1225                1230        
Tyr Ile Pro Leu Cys Pro Gly Ala Tyr Thr Val Thr Ile Lys Tyr Gly
        1235                1240                1245            
Gly Gln Pro Val Pro Asn Phe Pro Ser Lys Leu Gln Val Glu Pro Ala
    1250                1255                1260                
Val Asp Thr Ser Gly Val Gln Cys Tyr Gly Pro Gly Ile Glu Gly Gln
1265                1270                1275                1280
Gly Val Phe Arg Glu Ala Thr Thr Glu Phe Ser Val Asp Ala Arg Ala
                1285                1290                1295    
Leu Thr Gln Thr Gly Gly Pro His Val Lys Ala Arg Val Ala Asn Pro
            1300                1305                1310        
Ser Gly Asn Leu Thr Glu Thr Tyr Val Gln Asp Arg Gly Asp Gly Met
        1315                1320                1325            
Tyr Lys Val Glu Tyr Thr Pro Tyr Glu Glu Gly Leu His Ser Val Asp
    1330                1335                1340                
Val Thr Tyr Asp Gly Ser Pro Val Pro Ser Ser Pro Phe Gln Val Pro
1345                1350                1355                1360
Val Thr Glu Gly Cys Asp Pro Ser Arg Val Arg Val His Gly Pro Gly
                1365                1370                1375    
Ile Gln Ser Gly Thr Thr Asn Lys Pro Asn Lys Phe Thr Val Glu Thr
            1380                1385                1390        
Arg Gly Ala Gly Thr Gly Gly Leu Gly Leu Ala Val Glu Gly Pro Ser
        1395                1400                1405            
Glu Ala Lys Met Ser Cys Met Asp Asn Lys Asp Gly Ser Cys Ser Val
    1410                1415                1420                
Glu Tyr Ile Pro Tyr Glu Ala Gly Thr Tyr Ser Leu Asn Val Thr Tyr
1425                1430                1435                1440
Gly Gly His Gln Val Pro Gly Ser Pro Phe Lys Val Pro Val His Asp
                1445                1450                1455    
Val Thr Asp Ala Ser Lys Val Lys Cys Ser Gly Pro Gly Leu Ser Pro
            1460                1465                1470        
Gly Met Val Arg Ala Asn Leu Pro Gln Ser Phe Gln Val Asp Thr Ser
        1475                1480                1485            
Lys Ala Gly Val Ala Pro Leu Gln Val Lys Val Gln Gly Pro Lys Gly
    1490                1495                1500                
Leu Val Glu Pro Val Asp Val Val Asp Asn Ala Asp Gly Thr Gln Thr
1505                1510                1515                1520
Val Asn Tyr Val Pro Ser Arg Glu Gly Pro Tyr Ser Ile Ser Val Leu
                1525                1530                1535    
Tyr Gly Asp Glu Glu Val Pro Arg Ser Pro Phe Lys Val Lys Val Leu
            1540                1545                1550        
Pro Thr His Asp Ala Ser Lys Val Lys Ala Ser Gly Pro Gly Leu Asn
        1555                1560                1565            
Thr Thr Gly Val Pro Ala Ser Leu Pro Val Glu Phe Thr Ile Asp Ala
    1570                1575                1580                
Lys Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile Thr Asp Pro Glu
1585                1590                1595                1600
Gly Lys Pro Lys Lys Thr His Ile Gln Asp Asn His Asp Gly Thr Tyr
                1605                1610                1615    
Thr Val Ala Tyr Val Pro Asp Val Thr Gly Arg Tyr Thr Ile Leu Ile
            1620                1625                1630        
Lys Tyr Gly Gly Asp Glu Ile Pro Phe Ser Pro Tyr Arg Val Arg Ala
        1635                1640                1645            
Val Pro Thr Gly Asp Ala Ser Lys Cys Thr Val Thr Gly Ala Gly Ile
    1650                1655                1660                
Gly Pro Thr Ile Gln Ile Gly Glu Glu Thr Val Ile Thr Val Asp Thr
1665                1670                1675                1680
Lys Ala Ala Gly Lys Gly Lys Val Thr Cys Thr Val Cys Thr Pro Asp
                1685                1690                1695    
Gly Ser Glu Val Asp Val Asp Val Val Glu Asn Glu Asp Gly Thr Phe
            1700                1705                1710        
Asp Ile Phe Tyr Thr Ala Pro Gln Pro Gly Lys Tyr Val Ile Cys Val
        1715                1720                1725            
Arg Phe Gly Gly Glu His Val Pro Asn Ser Pro Phe Gln Val Thr Ala
    1730                1735                1740                
Leu Ala Gly Asp Gln Pro Ser Val Gln Pro Pro Leu Arg Ser Gln Gln
1745                1750                1755                1760
Leu Ala Pro Gln Tyr Thr Tyr Ala Gln Gly Gly Gln Gln Thr Trp Ala
                1765                1770                1775    
Pro Glu Arg Pro Leu Val Gly Val Asn Gly Leu Asp Val Thr Ser Leu
            1780                1785                1790        
Arg Pro Phe Asp Leu Val Ile Pro Phe Thr Ile Lys Lys Gly Glu Ile
        1795                1800                1805            
Thr Gly Glu Val Arg Met Pro Ser Gly Lys Val Ala Gln Pro Thr Ile
    1810                1815                1820                
Thr Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Ser Glu
1825                1830                1835                1840
Ala Gly Leu His Glu Met Asp Ile Arg Tyr Asp Asn Met His Ile Pro
                1845                1850                1855    
Gly Ser Pro Leu Gln Phe Tyr Val Asp Tyr Val Asn Cys Gly His Val
            1860                1865                1870        
Thr Ala Tyr Gly Pro Gly Leu Thr His Gly Val Val Asn Lys Pro Ala
        1875                1880                1885            
Thr Phe Thr Val Asn Thr Lys Asp Ala Gly Glu Gly Gly Leu Ser Leu
    1890                1895                1900                
Ala Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Thr Asp Asn Gln
1905                1910                1915                1920
Asp Gly Thr Cys Ser Val Ser Tyr Leu Pro Val Leu Pro Gly Asp Tyr
                1925                1930                1935    
Ser Ile Leu Val Lys Tyr Asn Glu Gln His Val Pro Gly Ser Pro Phe
            1940                1945                1950        
Thr Ala Arg Val Thr Gly Asp Asp Ser Met Arg Met Ser His Leu Lys
        1955                1960                1965            
Val Gly Ser Ala Ala Asp Ile Pro Ile Asn Ile Ser Glu Thr Asp Leu
    1970                1975                1980                
Ser Leu Leu Thr Ala Thr Val Val Pro Pro Ser Gly Arg Glu Glu Pro
1985                1990                1995                2000
Cys Leu Leu Lys Arg Leu Arg Asn Gly His Val Gly Ile Ser Phe Val
                2005                2010                2015    
Pro Lys Glu Thr Gly Glu His Leu Val His Val Lys Lys Asn Gly Gln
            2020                2025                2030        
His Val Ala Ser Ser Pro Ile Pro Val Val Ile Ser Gln Ser Glu Ile
        2035                2040                2045            
Gly Asp Ala Ser Arg Val Arg Val Ser Gly Gln Gly Leu His Glu Gly
    2050                2055                2060                
His Thr Phe Glu Pro Ala Glu Phe Ile Ile Asp Thr Arg Asp Ala Gly
2065                2070                2075                2080
Tyr Gly Gly Leu Ser Leu Ser Ile Glu Gly Pro Ser Lys Val Asp Ile
                2085                2090                2095    
Asn Thr Glu Asp Leu Glu Asp Gly Thr Cys Arg Val Thr Tyr Cys Pro
            2100                2105                2110        
Thr Glu Pro Gly Asn Tyr Ile Ile Asn Ile Lys Phe Ala Asp Gln His
        2115                2120                2125            
Val Pro Gly Ser Pro Phe Ser Val Lys Val Thr Gly Glu Gly Arg Val
    2130                2135                2140                
Lys Glu Ser Ile Thr Arg Arg Arg Arg Ala Pro Ser Val Ala Asn Val
2145                2150                2155                2160
Gly Ser His Cys Asp Leu Ser Leu Lys Ile Pro Glu Ile Ser Ile Gln
                2165                2170                2175    
Asp Met Thr Ala Gln Val Thr Ser Pro Ser Gly Lys Thr His Glu Ala
            2180                2185                2190        
Glu Ile Val Glu Gly Glu Asn His Thr Tyr Cys Ile Arg Phe Val Pro
        2195                2200                2205            
Ala Glu Met Gly Thr His Thr Val Ser Val Lys Tyr Lys Gly Gln His
    2210                2215                2220                
Val Pro Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly
2225                2230                2235                2240
Gly Ala His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Ala Glu
                2245                2250                2255    
Ala Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala
            2260                2265                2270        
Gly Gly Leu Ala Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Ser
        2275                2280                2285            
Phe Glu Asp Arg Lys Asp Gly Ser Cys Gly Val Ala Tyr Val Val Gln
    2290                2295                2300                
Glu Pro Gly Asp Tyr Glu Val Ser Val Lys Phe Asn Glu Glu His Ile
2305                2310                2315                2320
Pro Asp Ser Pro Phe Val Val Pro Val Ala Ser Pro Ser Gly Asp Ala
                2325                2330                2335    
Arg Arg Leu Thr Val Ser Ser Leu Arg Glu Ser Gly Leu Lys Val Asn
            2340                2345                2350        
Gln Pro Ala Ser Phe Ala Val Ser Leu Asn Gly Ala Lys Gly Ala Ile
        2355                2360                2365            
Asp Ala Lys Val His Ser Pro Ser Gly Ala Leu Glu Glu Cys Tyr Val
    2370                2375                2380                
Thr Glu Ile Asp Gln Asp Lys Tyr Ala Val Arg Phe Ile Pro Arg Glu
2385                2390                2395                2400
Asn Gly Val Tyr Leu Ile Asp Val Lys Phe Asn Gly Thr His Ile Pro
                2405                2410                2415    
Gly Ser Pro Phe Lys Ile Arg Val Gly Glu Pro Gly His Gly Gly Asp
            2420                2425                2430        
Pro Gly Leu Val Ser Ala Tyr Gly Ala Gly Leu Glu Gly Gly Val Thr
        2435                2440                2445            
Gly Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly
    2450                2455                2460                
Ala Leu Ser Val Thr Ile Asp Gly Pro Ser Lys Val Lys Met Asp Cys
2465                2470                2475                2480
Gln Glu Cys Pro Glu Gly Tyr Arg Val Thr Tyr Thr Pro Met Ala Pro
                2485                2490                2495    
Gly Ser Tyr Leu Ile Ser Ile Lys Tyr Gly Gly Pro Tyr His Ile Gly
            2500                2505                2510        
Gly Ser Pro Phe Lys Ala Lys Val Thr Gly Pro Arg Leu Val Ser Asn
        2515                2520                2525            
His Ser Leu His Glu Thr Ser Ser Val Phe Val Asp Ser Leu Thr Lys
    2530                2535                2540                
Ala Thr Cys Ala Pro Gln His Gly Ala Pro Gly Pro Gly Pro Ala Asp
2545                2550                2555                2560
Ala Ser Lys Val Val Ala Lys Gly Leu Gly Leu Ser Lys Ala Tyr Val
                2565                2570                2575    
Gly Gln Lys Ser Ser Phe Thr Val Asp Cys Ser Lys Ala Gly Asn Asn
            2580                2585                2590        
Met Leu Leu Val Gly Val His Gly Pro Arg Thr Pro Cys Glu Glu Ile
        2595                2600                2605            
Leu Val Lys His Val Gly Ser Arg Leu Tyr Ser Val Ser Tyr Leu Leu
    2610                2615                2620                
Lys Asp Lys Gly Glu Tyr Thr Leu Val Val Lys Trp Gly Asp Glu His
2625                2630                2635                2640
Ile Pro Gly Ser Pro Tyr Arg Val Val Val Pro
                2645                2650    


<210> 8530
<211> 2647
<212> PRT
<213> Homo sapiens

<400> 8530
Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala
 1               5                  10                  15      
Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu
            20                  25                  30          
Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr
        35                  40                  45              
Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile
    50                  55                  60                  
Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu
65                  70                  75                  80  
Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg
                85                  90                  95      
Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu
            100                 105                 110         
Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala
        115                 120                 125             
Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu
    130                 135                 140                 
Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp
145                 150                 155                 160 
Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile
                165                 170                 175     
Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp
            180                 185                 190         
Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly
        195                 200                 205             
Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn
    210                 215                 220                 
Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln
225                 230                 235                 240 
Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser
                245                 250                 255     
Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly
            260                 265                 270         
Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly
        275                 280                 285             
Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe
    290                 295                 300                 
Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val
305                 310                 315                 320 
Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn
                325                 330                 335     
Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly
            340                 345                 350         
Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser
        355                 360                 365             
Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val
    370                 375                 380                 
Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys
385                 390                 395                 400 
Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val
                405                 410                 415     
Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro
            420                 425                 430         
Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro
        435                 440                 445             
Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro
    450                 455                 460                 
Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro
465                 470                 475                 480 
Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg
                485                 490                 495     
Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser
            500                 505                 510         
Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val
        515                 520                 525             
Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro
    530                 535                 540                 
Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn
545                 550                 555                 560 
Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn
                565                 570                 575     
Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly
            580                 585                 590         
Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr
        595                 600                 605             
Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp
    610                 615                 620                 
Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala
625                 630                 635                 640 
Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu
                645                 650                 655     
Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro
            660                 665                 670         
Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala
        675                 680                 685             
Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys
    690                 695                 700                 
Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu
705                 710                 715                 720 
Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val
                725                 730                 735     
Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val
            740                 745                 750         
Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His
        755                 760                 765             
Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu
    770                 775                 780                 
Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly
785                 790                 795                 800 
Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly
                805                 810                 815     
Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp
            820                 825                 830         
Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile
        835                 840                 845             
Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val
    850                 855                 860                 
Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro
865                 870                 875                 880 
Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr
                885                 890                 895     
Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser
            900                 905                 910         
Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His
        915                 920                 925             
His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro
    930                 935                 940                 
Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro
945                 950                 955                 960 
Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val
                965                 970                 975     
Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr
            980                 985                 990         
Val Lys Ser Lys Gly Ala Gly Gly Gln Gly Lys Val Ala Ser Lys Ile
        995                 1000                1005            
Val Gly Pro Ser Gly Ala Ala Val Pro Cys Lys Val Glu Pro Gly Leu
    1010                1015                1020                
Gly Ala Asp Asn Ser Val Val Arg Phe Leu Pro Arg Glu Glu Gly Pro
1025                1030                1035                1040
Tyr Glu Val Glu Val Thr Tyr Asp Gly Val Pro Val Pro Gly Ser Pro
                1045                1050                1055    
Phe Pro Leu Glu Ala Val Ala Pro Thr Lys Pro Ser Lys Val Lys Ala
            1060                1065                1070        
Phe Gly Pro Gly Leu Gln Gly Gly Ser Ala Gly Ser Pro Ala Arg Phe
        1075                1080                1085            
Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val
    1090                1095                1100                
Glu Gly Pro Cys Glu Ala Gln Leu Glu Cys Leu Asp Asn Gly Asp Gly
1105                1110                1115                1120
Thr Cys Ser Val Ser Tyr Val Pro Thr Glu Pro Gly Asp Tyr Asn Ile
                1125                1130                1135    
Asn Ile Leu Phe Ala Asp Thr His Ile Pro Gly Ser Pro Phe Lys Ala
            1140                1145                1150        
His Val Val Pro Cys Phe Asp Ala Ser Lys Val Lys Cys Ser Gly Pro
        1155                1160                1165            
Gly Leu Glu Arg Ala Thr Ala Gly Glu Val Gly Gln Phe Gln Val Asp
    1170                1175                1180                
Cys Ser Ser Ala Gly Ser Ala Glu Leu Thr Ile Glu Ile Cys Ser Glu
1185                1190                1195                1200
Ala Gly Leu Pro Ala Glu Val Tyr Ile Gln Asp His Gly Asp Gly Thr
                1205                1210                1215    
His Thr Ile Thr Tyr Ile Pro Leu Cys Pro Gly Ala Tyr Thr Val Thr
            1220                1225                1230        
Ile Lys Tyr Gly Gly Gln Pro Val Pro Asn Phe Pro Ser Lys Leu Gln
        1235                1240                1245            
Val Glu Pro Ala Val Asp Thr Ser Gly Val Gln Cys Tyr Gly Pro Gly
    1250                1255                1260                
Ile Glu Gly Gln Gly Val Phe Arg Glu Ala Thr Thr Glu Phe Ser Val
1265                1270                1275                1280
Asp Ala Arg Ala Leu Thr Gln Thr Gly Gly Pro His Val Lys Ala Arg
                1285                1290                1295    
Val Ala Asn Pro Ser Gly Asn Leu Thr Glu Thr Tyr Val Gln Asp Arg
            1300                1305                1310        
Gly Asp Gly Met Tyr Lys Val Glu Tyr Thr Pro Tyr Glu Glu Gly Leu
        1315                1320                1325            
His Ser Val Asp Val Thr Tyr Asp Gly Ser Pro Val Pro Ser Ser Pro
    1330                1335                1340                
Phe Gln Val Pro Val Thr Glu Gly Cys Asp Pro Ser Arg Val Arg Val
1345                1350                1355                1360
His Gly Pro Gly Ile Gln Ser Gly Thr Thr Asn Lys Pro Asn Lys Phe
                1365                1370                1375    
Thr Val Glu Thr Arg Gly Ala Gly Thr Gly Gly Leu Gly Leu Ala Val
            1380                1385                1390        
Glu Gly Pro Ser Glu Ala Lys Met Ser Cys Met Asp Asn Lys Asp Gly
        1395                1400                1405            
Ser Cys Ser Val Glu Tyr Ile Pro Tyr Glu Ala Gly Thr Tyr Ser Leu
    1410                1415                1420                
Asn Val Thr Tyr Gly Gly His Gln Val Pro Gly Ser Pro Phe Lys Val
1425                1430                1435                1440
Pro Val His Asp Val Thr Asp Ala Ser Lys Val Lys Cys Ser Gly Pro
                1445                1450                1455    
Gly Leu Ser Pro Gly Met Val Arg Ala Asn Leu Pro Gln Ser Phe Gln
            1460                1465                1470        
Val Asp Thr Ser Lys Ala Gly Val Ala Pro Leu Gln Val Lys Val Gln
        1475                1480                1485            
Gly Pro Lys Gly Leu Val Glu Pro Val Asp Val Val Asp Asn Ala Asp
    1490                1495                1500                
Gly Thr Gln Thr Val Asn Tyr Val Pro Ser Arg Glu Gly Pro Tyr Ser
1505                1510                1515                1520
Ile Ser Val Leu Tyr Gly Asp Glu Glu Val Pro Arg Ser Pro Phe Lys
                1525                1530                1535    
Val Lys Val Leu Pro Thr His Asp Ala Ser Lys Val Lys Ala Ser Gly
            1540                1545                1550        
Pro Gly Leu Asn Thr Thr Gly Val Pro Ala Ser Leu Pro Val Glu Phe
        1555                1560                1565            
Thr Ile Asp Ala Lys Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile
    1570                1575                1580                
Thr Asp Pro Glu Gly Lys Pro Lys Lys Thr His Ile Gln Asp Asn His
1585                1590                1595                1600
Asp Gly Thr Tyr Thr Val Ala Tyr Val Pro Asp Val Thr Gly Arg Tyr
                1605                1610                1615    
Thr Ile Leu Ile Lys Tyr Gly Gly Asp Glu Ile Pro Phe Ser Pro Tyr
            1620                1625                1630        
Arg Val Arg Ala Val Pro Thr Gly Asp Ala Ser Lys Cys Thr Val Thr
        1635                1640                1645            
Val Ser Ile Gly Gly His Gly Leu Gly Ala Gly Ile Gly Pro Thr Ile
    1650                1655                1660                
Gln Ile Gly Glu Glu Thr Val Ile Thr Val Asp Thr Lys Ala Ala Gly
1665                1670                1675                1680
Lys Gly Lys Val Thr Cys Thr Val Cys Thr Pro Asp Gly Ser Glu Val
                1685                1690                1695    
Asp Val Asp Val Val Glu Asn Glu Asp Gly Thr Phe Asp Ile Phe Tyr
            1700                1705                1710        
Thr Ala Pro Gln Pro Gly Lys Tyr Val Ile Cys Val Arg Phe Gly Gly
        1715                1720                1725            
Glu His Val Pro Asn Ser Pro Phe Gln Val Thr Ala Leu Ala Gly Asp
    1730                1735                1740                
Gln Pro Ser Val Gln Pro Pro Leu Arg Ser Gln Gln Leu Ala Pro Gln
1745                1750                1755                1760
Tyr Thr Tyr Ala Gln Gly Gly Gln Gln Thr Trp Ala Pro Glu Arg Pro
                1765                1770                1775    
Leu Val Gly Val Asn Gly Leu Asp Val Thr Ser Leu Arg Pro Phe Asp
            1780                1785                1790        
Leu Val Ile Pro Phe Thr Ile Lys Lys Gly Glu Ile Thr Gly Glu Val
        1795                1800                1805            
Arg Met Pro Ser Gly Lys Val Ala Gln Pro Thr Ile Thr Asp Asn Lys
    1810                1815                1820                
Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Ser Glu Ala Gly Leu His
1825                1830                1835                1840
Glu Met Asp Ile Arg Tyr Asp Asn Met His Ile Pro Gly Ser Pro Leu
                1845                1850                1855    
Gln Phe Tyr Val Asp Tyr Val Asn Cys Gly His Val Thr Ala Tyr Gly
            1860                1865                1870        
Pro Gly Leu Thr His Gly Val Val Asn Lys Pro Ala Thr Phe Thr Val
        1875                1880                1885            
Asn Thr Lys Asp Ala Gly Glu Gly Gly Leu Ser Leu Ala Ile Glu Gly
    1890                1895                1900                
Pro Ser Lys Ala Glu Ile Ser Cys Thr Asp Asn Gln Asp Gly Thr Cys
1905                1910                1915                1920
Ser Val Ser Tyr Leu Pro Val Leu Pro Gly Asp Tyr Ser Ile Leu Val
                1925                1930                1935    
Lys Tyr Asn Glu Gln His Val Pro Gly Ser Pro Phe Thr Ala Arg Val
            1940                1945                1950        
Thr Gly Asp Asp Ser Met Arg Met Ser His Leu Lys Val Gly Ser Ala
        1955                1960                1965            
Ala Asp Ile Pro Ile Asn Ile Ser Glu Thr Asp Leu Ser Leu Leu Thr
    1970                1975                1980                
Ala Thr Val Val Pro Pro Ser Gly Arg Glu Glu Pro Cys Leu Leu Lys
1985                1990                1995                2000
Arg Leu Arg Asn Gly His Val Gly Ile Ser Phe Val Pro Lys Glu Thr
                2005                2010                2015    
Gly Glu His Leu Val His Val Lys Lys Asn Gly Gln His Val Ala Ser
            2020                2025                2030        
Ser Pro Ile Pro Val Val Ile Ser Gln Ser Glu Ile Gly Asp Ala Ser
        2035                2040                2045            
Arg Val Arg Val Ser Gly Gln Gly Leu His Glu Gly His Thr Phe Glu
    2050                2055                2060                
Pro Ala Glu Phe Ile Ile Asp Thr Arg Asp Ala Gly Tyr Gly Gly Leu
2065                2070                2075                2080
Ser Leu Ser Ile Glu Gly Pro Ser Lys Val Asp Ile Asn Thr Glu Asp
                2085                2090                2095    
Leu Glu Asp Gly Thr Cys Arg Val Thr Tyr Cys Pro Thr Glu Pro Gly
            2100                2105                2110        
Asn Tyr Ile Ile Asn Ile Lys Phe Ala Asp Gln His Val Pro Gly Ser
        2115                2120                2125            
Pro Phe Ser Val Lys Val Thr Gly Glu Gly Arg Val Lys Glu Ser Ile
    2130                2135                2140                
Thr Arg Arg Arg Arg Ala Pro Ser Val Ala Asn Val Gly Ser His Cys
2145                2150                2155                2160
Asp Leu Ser Leu Lys Ile Pro Glu Ile Ser Ile Gln Asp Met Thr Ala
                2165                2170                2175    
Gln Val Thr Ser Pro Ser Gly Lys Thr His Glu Ala Glu Ile Val Glu
            2180                2185                2190        
Gly Glu Asn His Thr Tyr Cys Ile Arg Phe Val Pro Ala Glu Met Gly
        2195                2200                2205            
Thr His Thr Val Ser Val Lys Tyr Lys Gly Gln His Val Pro Gly Ser
    2210                2215                2220                
Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala His Lys
2225                2230                2235                2240
Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Ala Glu Ala Gly Val Pro
                2245                2250                2255    
Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly Leu Ala
            2260                2265                2270        
Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Ser Phe Glu Asp Arg
        2275                2280                2285            
Lys Asp Gly Ser Cys Gly Val Ala Tyr Val Val Gln Glu Pro Gly Asp
    2290                2295                2300                
Tyr Glu Val Ser Val Lys Phe Asn Glu Glu His Ile Pro Asp Ser Pro
2305                2310                2315                2320
Phe Val Val Pro Val Ala Ser Pro Ser Gly Asp Ala Arg Arg Leu Thr
                2325                2330                2335    
Val Ser Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln Pro Ala Ser
            2340                2345                2350        
Phe Ala Val Ser Leu Asn Gly Ala Lys Gly Ala Ile Asp Ala Lys Val
        2355                2360                2365            
His Ser Pro Ser Gly Ala Leu Glu Glu Cys Tyr Val Thr Glu Ile Asp
    2370                2375                2380                
Gln Asp Lys Tyr Ala Val Arg Phe Ile Pro Arg Glu Asn Gly Val Tyr
2385                2390                2395                2400
Leu Ile Asp Val Lys Phe Asn Gly Thr His Ile Pro Gly Ser Pro Phe
                2405                2410                2415    
Lys Ile Arg Val Gly Glu Pro Gly His Gly Gly Asp Pro Gly Leu Val
            2420                2425                2430        
Ser Ala Tyr Gly Ala Gly Leu Glu Gly Gly Val Thr Gly Asn Pro Ala
        2435                2440                2445            
Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly Ala Leu Ser Val
    2450                2455                2460                
Thr Ile Asp Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu Cys Pro
2465                2470                2475                2480
Glu Gly Tyr Arg Val Thr Tyr Thr Pro Met Ala Pro Gly Ser Tyr Leu
                2485                2490                2495    
Ile Ser Ile Lys Tyr Gly Gly Pro Tyr His Ile Gly Gly Ser Pro Phe
            2500                2505                2510        
Lys Ala Lys Val Thr Gly Pro Arg Leu Val Ser Asn His Ser Leu His
        2515                2520                2525            
Glu Thr Ser Ser Val Phe Val Asp Ser Leu Thr Lys Ala Thr Cys Ala
    2530                2535                2540                
Pro Gln His Gly Ala Pro Gly Pro Gly Pro Ala Asp Ala Ser Lys Val
2545                2550                2555                2560
Val Ala Lys Gly Leu Gly Leu Ser Lys Ala Tyr Val Gly Gln Lys Ser
                2565                2570                2575    
Ser Phe Thr Val Asp Cys Ser Lys Ala Gly Asn Asn Met Leu Leu Val
            2580                2585                2590        
Gly Val His Gly Pro Arg Thr Pro Cys Glu Glu Ile Leu Val Lys His
        2595                2600                2605            
Val Gly Ser Arg Leu Tyr Ser Val Ser Tyr Leu Leu Lys Asp Lys Gly
    2610                2615                2620                
Glu Tyr Thr Leu Val Val Lys Trp Gly His Glu His Ile Pro Gly Ser
2625                2630                2635                2640
Pro Tyr Arg Val Val Val Pro
                2645        


<210> 8531
<211> 605
<212> PRT
<213> Homo sapiens

<400> 8531
Met Val Ser Asn His Tyr Phe Leu Leu Cys Val Asn Leu Pro Leu Arg
 1               5                  10                  15      
Glu Ile His Thr Pro Gly Pro Ser Pro Ser Cys Leu Gly Asp Ser Leu
            20                  25                  30          
Ala Glu Thr Thr Leu Ser Glu Asp Thr Thr Asp Ser Val Gly Ser Ala
        35                  40                  45              
Ser Pro His Gly Ser Ser Glu Lys Ser Ser Ser Phe Ser Leu Ser Ser
    50                  55                  60                  
Thr Glu Val His Met Val Arg Pro Gly Tyr Ser His Arg Val Ser Leu
65                  70                  75                  80  
Pro Thr Ser Pro Gly Ile Leu Ala Thr Ser Pro Tyr Pro Glu Thr Asp
                85                  90                  95      
Ser Ala Phe Phe Glu Pro Ser His Leu Thr Ser Ala Ala Asp Glu Gly
            100                 105                 110         
Ala Val Gln Val Ser Arg Arg Thr Ile Ser Ser Asn Ser Phe Ser Pro
        115                 120                 125             
Glu Val Phe Val Leu Pro Val Asp Val Glu Lys Glu Asn Ala His Phe
    130                 135                 140                 
Tyr Val Ala Asp Met Ile Ile Ser Ala Met Glu Lys Met Lys Cys Asn
145                 150                 155                 160 
Ile Leu Ser Gln Gln Gln Thr Glu Ser Trp Ser Lys Glu Val Ser Gly
                165                 170                 175     
Leu Leu Gly Ser Asp Gln Pro Asp Ser Glu Met Thr Phe Asp Thr Asn
            180                 185                 190         
Ile Lys Gln Glu Ser Gly Ser Ser Thr Ser Ser Tyr Ser Gly Tyr Glu
        195                 200                 205             
Gly Lys Leu Gly Lys Tyr Glu Lys Ala Val Cys Cys Ala Val Leu Gln
    210                 215                 220                 
Val Ser Pro Val Thr Glu Thr Arg Thr Tyr His Asp Val Lys Glu Ile
225                 230                 235                 240 
Cys Lys Cys Asp Val Asp Glu Phe Val Ile Leu Glu Leu Gly Asp Phe
                245                 250                 255     
Asn Asp Ile Thr Glu Thr Cys Ser Cys Ser Cys Ser Ser Ser Lys Ser
            260                 265                 270         
Val Thr Tyr Glu Pro Asp Phe Asn Ser Ala Glu Leu Leu Ala Lys Glu
        275                 280                 285             
Leu Tyr Arg Val Phe Gln Lys Cys Trp Ile Leu Ser Val Val Asn Ser
    290                 295                 300                 
Gln Leu Ala Gly Ser Leu Ser Ala Ala Gly Ser Ile Val Val Asn Glu
305                 310                 315                 320 
Glu Cys Val Arg Lys Asp Phe Glu Ser Ser Met Asn Val Val Gln Glu
                325                 330                 335     
Ile Lys Phe Lys Ser Arg Ile Arg Gly Thr Glu Asp Trp Ala Pro Pro
            340                 345                 350         
Arg Phe Gln Ile Ile Phe Asn Ile His Pro Pro Leu Lys Arg Asp Leu
        355                 360                 365             
Val Val Ala Ala Gln Asn Phe Phe Cys Ala Gly Cys Gly Thr Pro Val
    370                 375                 380                 
Glu Pro Lys Phe Val Lys Arg Leu Arg Tyr Cys Glu Tyr Leu Gly Lys
385                 390                 395                 400 
Tyr Phe Cys Asp Cys Cys His Ser Tyr Ala Glu Ser Cys Ile Pro Ala
                405                 410                 415     
Arg Ile Leu Met Met Trp Asp Phe Lys Lys Tyr Tyr Val Ser Asn Phe
            420                 425                 430         
Ser Lys Gln Leu Leu Asp Ser Ile Trp His Gln Pro Ile Phe Asn Leu
        435                 440                 445             
Leu Ser Ile Gly Gln Ser Leu Tyr Ala Lys Ala Lys Glu Leu Asp Arg
    450                 455                 460                 
Val Lys Glu Ile Gln Glu Gln Leu Phe His Ile Lys Lys Leu Leu Lys
465                 470                 475                 480 
Thr Cys Arg Phe Ala Asn Ser Ala Leu Lys Glu Phe Glu Gln Val Pro
                485                 490                 495     
Gly His Leu Thr Asp Glu Leu His Leu Phe Ser Leu Glu Asp Leu Val
            500                 505                 510         
Arg Ile Lys Lys Gly Leu Leu Ala Pro Leu Leu Lys Asp Ile Leu Lys
        515                 520                 525             
Ala Ser Leu Ala His Val Ala Gly Cys Glu Leu Cys Gln Gly Lys Gly
    530                 535                 540                 
Phe Ile Cys Glu Phe Cys Gln Asn Thr Thr Val Ile Phe Pro Phe Gln
545                 550                 555                 560 
Thr Ala Thr Cys Arg Arg Cys Ser Ala Cys Arg Ala Cys Phe His Lys
                565                 570                 575     
Gln Cys Phe Gln Ser Ser Glu Cys Pro Arg Cys Ala Arg Ile Thr Ala
            580                 585                 590         
Arg Arg Lys Leu Leu Glu Ser Val Ala Ser Ala Ala Thr
        595                 600                 605 


<210> 8532
<211> 465
<212> PRT
<213> Homo sapiens

<400> 8532
Pro Leu Lys Lys Ala Leu Arg Met Met Gly Ala Pro Asn Leu Ile Ser
 1               5                  10                  15      
Asp Asn Leu Asp Cys Gly Leu Ser Tyr Ser Val Ile Ser Tyr Leu Lys
            20                  25                  30          
Lys Leu Ser Gln Gln Thr Lys Leu Glu Ser Glu Arg Ile Leu Ala Ser
        35                  40                  45              
Val Gly Lys Lys Pro Pro Gln Glu Ile Gly Ile Lys Val Lys Asn His
    50                  55                  60                  
Ser Gly Gly Gly Met Ser Leu Thr His Asn Lys Asn Phe Arg Lys Leu
65                  70                  75                  80  
Leu Lys Glu Ile Thr Gly Glu Thr Ala Leu Arg Leu Thr Glu Leu Asn
                85                  90                  95      
Thr Lys Glu Phe Ala Gly Phe Gln Ile Gly Leu Leu Asn Lys Asp Leu
            100                 105                 110         
Lys Pro Gln Thr Tyr Arg Asn Ala Tyr Asp Ile Pro Arg Arg Gly Leu
        115                 120                 125             
Leu Asp Gln Leu Thr Arg Met Arg Ser Asn Leu Leu Lys Thr His Lys
    130                 135                 140                 
Phe Ile Val Gly Gln Asp Glu Asp Ser Leu His Ser Val Pro Val Ala
145                 150                 155                 160 
Gln Met Gly Asn Tyr Gln Glu Tyr Leu Lys Thr Leu Ala Ser Pro Leu
                165                 170                 175     
Arg Glu Ile Asp Pro Asp Gln Pro Lys Arg Leu His Thr Phe Gly Asn
            180                 185                 190         
Pro Phe Lys Gln Asp Lys Lys Gly Met Met Ile Asp Glu Ala Asp Glu
        195                 200                 205             
Phe Val Ala Gly Pro Gln Asn Lys Val Lys Arg Pro Gly Glu Pro Asn
    210                 215                 220                 
Ser Pro Met Ser Ser Lys Arg Arg Arg Ser Met Ser Leu Leu Leu Arg
225                 230                 235                 240 
Lys Pro Gln Thr Pro Pro Thr Val Thr Asn His Val Gly Gly Lys Gly
                245                 250                 255     
Pro Pro Ser Ala Ser Trp Phe Pro Ser Tyr Pro Asn Leu Ile Lys Pro
            260                 265                 270         
Thr Leu Val His Thr Asp Ala Thr Ile Ile His Asp Gly His Glu Glu
        275                 280                 285             
Lys Met Glu Asn Gly Gln Ile Thr Pro Asp Gly Phe Leu Ser Lys Ser
    290                 295                 300                 
Ala Pro Ser Glu Leu Ile Asn Met Thr Gly Asp Leu Met Pro Pro Asn
305                 310                 315                 320 
Gln Val Asp Ser Leu Ser Asp Asp Phe Thr Ser Leu Ser Lys Asp Gly
                325                 330                 335     
Leu Ile Gln Lys Pro Gly Ser Asn Ala Phe Val Gly Gly Ala Lys Asn
            340                 345                 350         
Cys Ser Leu Ser Val Asp Asp Gln Lys Asp Pro Val Ala Ser Thr Leu
        355                 360                 365             
Gly Ala Met Pro Asn Thr Leu Gln Ile Thr Pro Ala Met Ala Gln Gly
    370                 375                 380                 
Ile Asn Ala Asp Ile Lys His Gln Leu Met Lys Glu Val Arg Lys Phe
385                 390                 395                 400 
Gly Arg Lys Tyr Glu Arg Ile Phe Ile Leu Leu Glu Glu Val Gln Gly
                405                 410                 415     
Pro Leu Glu Met Lys Lys Gln Phe Val Glu Phe Thr Ile Lys Glu Ala
            420                 425                 430         
Ala Arg Phe Lys Arg Arg Val Leu Ile Gln Tyr Leu Glu Lys Val Leu
        435                 440                 445             
Glu Lys Ile Asn Ser His His Leu His Asn Asn Ile Ser His Ile Asn
    450                 455                 460                 
Ser
465 


<210> 8533
<211> 642
<212> PRT
<213> Homo sapiens

<400> 8533
Met Ile Pro Asn Gly Tyr Leu Met Phe Glu Asp Glu Asn Phe Ile Glu
 1               5                  10                  15      
Ser Ser Val Ala Lys Leu Asn Ala Leu Arg Lys Ser Gly Gln Phe Cys
            20                  25                  30          
Asp Val Arg Leu Gln Val Cys Gly His Glu Met Leu Ala His Arg Ala
        35                  40                  45              
Val Leu Ala Cys Cys Ser Pro Tyr Leu Phe Glu Ile Phe Asn Ser Asp
    50                  55                  60                  
Ser Asp Pro His Gly Ile Ser His Val Lys Phe Asp Asp Leu Asn Pro
65                  70                  75                  80  
Glu Ala Val Glu Val Leu Leu Asn Tyr Ala Tyr Thr Ala Gln Leu Lys
                85                  90                  95      
Ala Asp Lys Glu Leu Val Lys Asp Val Tyr Ser Ala Ala Lys Lys Leu
            100                 105                 110         
Lys Met Asp Arg Val Lys Gln Val Cys Gly Asp Tyr Leu Leu Ser Arg
        115                 120                 125             
Met Asp Val Thr Ser Cys Ile Ser Tyr Arg Asn Phe Ala Ser Cys Met
    130                 135                 140                 
Gly Asp Ser Arg Leu Leu Asn Lys Val Asp Ala Tyr Ile Gln Glu His
145                 150                 155                 160 
Leu Leu Gln Ile Ser Glu Glu Glu Glu Phe Leu Lys Leu Pro Arg Leu
                165                 170                 175     
Lys Leu Glu Val Met Leu Glu Asp Asn Val Cys Leu Pro Ser Asn Gly
            180                 185                 190         
Lys Leu Tyr Thr Lys Val Ile Asn Trp Val Gln Arg Ser Ile Trp Glu
        195                 200                 205             
Asn Gly Asp Ser Leu Glu Glu Leu Met Glu Glu Val Gln Thr Leu Tyr
    210                 215                 220                 
Tyr Ser Ala Asp His Lys Leu Leu Asp Gly Asn Leu Leu Asp Gly Gln
225                 230                 235                 240 
Ala Glu Val Phe Gly Ser Asp Asp Asp His Ile Gln Phe Val Gln Lys
                245                 250                 255     
Lys Pro Pro Arg Glu Asn Gly His Lys Gln Ile Ser Ser Ser Ser Thr
            260                 265                 270         
Gly Cys Leu Ser Ser Pro Asn Ala Thr Val Gln Ser Pro Lys His Glu
        275                 280                 285             
Trp Lys Ile Val Ala Ser Glu Lys Thr Ser Asn Asn Thr Tyr Leu Cys
    290                 295                 300                 
Leu Ala Val Leu Asp Gly Ile Phe Cys Val Ile Phe Leu His Gly Arg
305                 310                 315                 320 
Asn Ser Pro Gln Ser Ser Pro Thr Ser Thr Pro Lys Leu Ser Lys Ser
                325                 330                 335     
Leu Ser Phe Glu Met Gln Gln Asp Glu Leu Ile Glu Lys Pro Met Ser
            340                 345                 350         
Pro Met Gln Tyr Ala Arg Ser Gly Leu Gly Thr Ala Glu Met Asn Gly
        355                 360                 365             
Lys Leu Ile Ala Ala Gly Gly Tyr Asn Arg Glu Glu Cys Leu Arg Thr
    370                 375                 380                 
Val Glu Cys Tyr Asn Pro His Thr Asp His Trp Ser Phe Leu Ala Pro
385                 390                 395                 400 
Met Arg Thr Pro Arg Ala Arg Phe Gln Met Ala Val Leu Met Gly Gln
                405                 410                 415     
Leu Tyr Val Val Gly Gly Ser Asn Gly His Ser Asp Asp Leu Ser Cys
            420                 425                 430         
Gly Glu Met Tyr Asp Ser Asn Ile Asp Asp Trp Ile Pro Val Pro Glu
        435                 440                 445             
Leu Arg Thr Asn Arg Cys Asn Ala Gly Val Cys Ala Leu Asn Gly Lys
    450                 455                 460                 
Leu Tyr Ile Val Gly Gly Ser Asp Pro Tyr Gly Gln Lys Gly Leu Lys
465                 470                 475                 480 
Asn Cys Asp Val Phe Asp Pro Val Thr Lys Leu Trp Thr Ser Cys Ala
                485                 490                 495     
Pro Leu Asn Ile Arg Arg His Gln Ser Ala Val Cys Glu Leu Gly Gly
            500                 505                 510         
Tyr Leu Tyr Ile Ile Gly Gly Ala Glu Ser Trp Asn Cys Leu Asn Thr
        515                 520                 525             
Val Glu Arg Tyr Asn Pro Glu Asn Asn Thr Trp Thr Leu Ile Ala Pro
    530                 535                 540                 
Met Asn Val Ala Arg Arg Gly Ala Gly Val Ala Val Leu Asn Gly Lys
545                 550                 555                 560 
Leu Phe Val Cys Gly Gly Phe Asp Gly Ser His Ala Ile Ser Cys Val
                565                 570                 575     
Glu Met Tyr Asp Pro Thr Arg Asn Glu Trp Lys Met Met Gly Asn Met
            580                 585                 590         
Thr Ser Pro Arg Ser Asn Ala Gly Ile Ala Thr Val Gly Asn Thr Ile
        595                 600                 605             
Tyr Ala Val Gly Gly Phe Asp Gly Asn Glu Phe Leu Asn Thr Val Glu
    610                 615                 620                 
Val Tyr Asn Leu Glu Ser Asn Glu Trp Ser Pro Tyr Thr Lys Ile Phe
625                 630                 635                 640 
Gln Phe
        


<210> 8534
<211> 195
<212> PRT
<213> Homo sapiens

<400> 8534
Met Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu
 1               5                  10                  15      
Ile Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr
            20                  25                  30          
Ser Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg
        35                  40                  45              
Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp
    50                  55                  60                  
Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe
65                  70                  75                  80  
Arg Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn
                85                  90                  95      
Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser
            100                 105                 110         
Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu
        115                 120                 125             
Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly
    130                 135                 140                 
Val Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile
145                 150                 155                 160 
Gln Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe
                165                 170                 175     
Val Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg
            180                 185                 190         
Phe Leu His
        195 


<210> 8535
<211> 606
<212> PRT
<213> Homo sapiens

<400> 8535
Val Arg Phe Arg Asp Val Ala Val Val Phe Ser Pro Glu Glu Trp Asp
 1               5                  10                  15      
His Leu Thr Pro Glu Gln Arg Asn Leu Tyr Lys Asp Val Met Leu Asp
            20                  25                  30          
Asn Cys Lys Tyr Leu Ala Ser Leu Gly Asn Trp Thr Tyr Lys Ala His
        35                  40                  45              
Val Met Ser Ser Leu Lys Gln Gly Lys Glu Pro Trp Met Met Glu Arg
    50                  55                  60                  
Glu Val Thr Asp Lys Ala Phe Thr Met Glu Asn Thr Glu His Ile Val
65                  70                  75                  80  
Leu Leu Ser Ser Ile Met Asn Val Met Thr Val Ala Trp Leu Leu Gly
                85                  90                  95      
Met Cys His Asn Leu Leu Asp Ile Arg Lys Ser Ile Arg Pro Ser Lys
            100                 105                 110         
Val Ile Gln His Gln Ser Met His Ser Gly Leu Lys Pro Tyr Lys Cys
        115                 120                 125             
Asp Val Cys Gln Lys Ala Phe Arg Phe Leu Ser Ser Leu Ser Ile His
    130                 135                 140                 
Gln Arg Phe His Val Gly Asn Arg Val Asn Leu Thr Arg His Gln Lys
145                 150                 155                 160 
Thr His Thr Gln Arg Lys Pro Phe Ser Cys Asn Phe Cys Gly Lys Thr
                165                 170                 175     
Phe His Arg Phe Ser Glu Lys Thr Gln His Leu Leu Ile His Thr Arg
            180                 185                 190         
Lys Lys Tyr Tyr Thr Cys Asn Tyr Cys Lys Lys Glu Phe Asn Pro Tyr
        195                 200                 205             
Ser Lys Phe Ile Leu His Gln Arg Thr His Thr Gly Glu Lys Pro His
    210                 215                 220                 
Lys Cys Asp Val Cys Glu Lys Ser Phe Lys Ser Ile Ser Asn Leu Asn
225                 230                 235                 240 
Lys His Gln Lys Thr His Thr Gly Glu Lys Pro Phe Ser Cys Asn Glu
                245                 250                 255     
Cys Lys Lys Thr Phe Ala Gln Arg Thr Asp Leu Ala Arg His Gln Gln
            260                 265                 270         
Ile His Thr Gly Lys Lys Ser Phe Ile Cys Ser Ser Cys Lys Lys Thr
        275                 280                 285             
Phe Val Arg Leu Ser Asp Leu Thr Gln His Lys Gly Thr His Thr Gly
    290                 295                 300                 
Glu Arg Pro Tyr Gln Cys Thr Thr Cys Glu Lys Ala Phe Lys Tyr Arg
305                 310                 315                 320 
Ser Asn Phe Thr Lys His Gln Lys Thr His Ser Ile Gly Arg Pro Phe
                325                 330                 335     
Ala Cys Asn Glu Cys Gly Lys Thr Tyr Arg Leu Asn Trp Glu Leu Asn
            340                 345                 350         
Gln His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu
        355                 360                 365             
Cys Gly Lys Arg Phe Asn Asn Asn Ser Asn Leu Asn Lys His Lys Lys
    370                 375                 380                 
Ile His Thr Gly Glu Lys His Phe Val Cys Asn Gln Cys Gly Lys Ala
385                 390                 395                 400 
Phe Ser Leu Asn Ser Lys Leu Ser Arg His Gln Arg Thr His Asn Lys
                405                 410                 415     
Lys Glu Asn Ser Ser Lys Ser Val Ser Asn Leu Asn Lys His Gln Lys
            420                 425                 430         
Thr His Ala Gly Glu Lys Pro Phe Pro Cys Asn Glu Cys Lys Lys Ala
        435                 440                 445             
Phe Ala Gln Arg Met Asp Leu Ala Arg His Gln Gln Ile His Thr Gly
    450                 455                 460                 
Arg Lys Pro Phe Ile Cys Ser Ser Cys Lys Lys Thr Phe Val Arg Leu
465                 470                 475                 480 
Ser Asp Leu Thr Gln His Lys Gly Thr His Thr Gly Glu Arg Pro Tyr
                485                 490                 495     
Gln Cys Thr Thr Cys Glu Lys Ala Phe Lys Tyr Gln Ser Asn Phe Thr
            500                 505                 510         
Lys His Gln Lys Thr His Ser Ile Gly Arg Pro Phe Thr Cys Asn Glu
        515                 520                 525             
Cys Gly Lys Thr Phe Arg Leu Asn Trp Lys Leu Asn Gln His Lys Lys
    530                 535                 540                 
Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys Gly Lys Cys
545                 550                 555                 560 
Phe Asn Asn Asn Ser Asn Leu Ser Lys His Lys Lys Ile His Thr Gly
                565                 570                 575     
Glu Lys His Phe Val Cys Asn Gln Cys Gly Lys Ala Phe Ser Leu Asn
            580                 585                 590         
Ser Lys Leu Ser Arg His Gln Ile Thr His Asn Lys Lys Lys
        595                 600                 605     


<210> 8536
<211> 586
<212> PRT
<213> Homo sapiens

<400> 8536
Leu Val Arg Phe Arg Asp Val Ala Val Val Phe Ser Pro Glu Glu Trp
 1               5                  10                  15      
Asp His Leu Thr Pro Glu Gln Arg Asn Leu Tyr Lys Asp Val Met Leu
            20                  25                  30          
Asp Asn Cys Lys Tyr Leu Ala Ser Leu Gly Asn Trp Thr Tyr Lys Ala
        35                  40                  45              
His Val Met Ser Ser Leu Lys Gln Gly Lys Glu Pro Trp Met Met Glu
    50                  55                  60                  
Arg Glu Val Thr Gly Asp Pro Cys Pro Gly Asn Lys Gln Met Glu Val
65                  70                  75                  80  
Ile Thr Ala His Thr Ser Thr Gln Ser Asn Leu Asp Thr Pro Pro Pro
                85                  90                  95      
Thr Pro Thr Arg Arg Ile Cys Thr Leu Tyr Lys His Phe Glu Cys Asn
            100                 105                 110         
Gln Cys Gly Glu Thr Phe Asn Arg Pro Ser Lys Val Ile Gln His Gln
        115                 120                 125             
Ser Met His Ser Gly Leu Lys Pro Tyr Lys Cys Asp Val Cys Gln Lys
    130                 135                 140                 
Ala Phe Arg Phe Leu Ser Ser Leu Ser Ile His Gln Arg Phe His Val
145                 150                 155                 160 
Gly Asn Arg Val Asn Leu Thr Arg His Gln Lys Thr His Thr Gln Arg
                165                 170                 175     
Lys Pro Phe Ser Cys Asn Phe Cys Gly Lys Thr Phe His Arg Phe Ser
            180                 185                 190         
Glu Lys Thr Gln His Leu Leu Ile His Thr Arg Lys Lys Tyr Tyr Thr
        195                 200                 205             
Cys Asn Tyr Cys Lys Lys Glu Phe Asn Pro Tyr Ser Lys Phe Ile Leu
    210                 215                 220                 
His Gln Arg Thr His Thr Gly Glu Lys Pro His Lys Cys Asp Val Cys
225                 230                 235                 240 
Glu Lys Ser Phe Lys Ser Ile Ser Asn Leu Asn Lys His Gln Lys Thr
                245                 250                 255     
His Thr Gly Glu Lys Pro Phe Ser Cys Asn Glu Cys Lys Lys Thr Phe
            260                 265                 270         
Ala Gln Arg Thr Asp Leu Ala Arg His Gln Gln Ile His Thr Gly Lys
        275                 280                 285             
Lys Ser Phe Ile Cys Ser Ser Cys Lys Lys Thr Phe Val Arg Leu Ser
    290                 295                 300                 
Asp Leu Thr Gln His Lys Gly Thr His Thr Gly Glu Arg Pro Tyr Gln
305                 310                 315                 320 
Cys Thr Thr Cys Glu Lys Ala Phe Lys Tyr Arg Ser Asn Phe Thr Lys
                325                 330                 335     
His Gln Lys Thr His Ser Ile Gly Arg Pro Phe Ala Cys Asn Glu Cys
            340                 345                 350         
Gly Lys Thr Tyr Arg Leu Asn Trp Glu Leu Asn Gln His Lys Lys Ile
        355                 360                 365             
His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys Gly Lys Arg Phe
    370                 375                 380                 
Asn Asn Asn Ser Asn Leu Asn Lys His Lys Lys Ile His Thr Gly Glu
385                 390                 395                 400 
Lys His Phe Val Cys Asn Gln Cys Gly Lys Ala Phe Ser Leu Asn Ser
                405                 410                 415     
Lys Leu Ser Arg His Gln Arg Thr His Asn Lys Lys Glu Asn Ser Ser
            420                 425                 430         
Lys Ser Val Ser Asn Leu Asn Lys His Gln Lys Thr His Ala Gly Glu
        435                 440                 445             
Lys Pro Phe Pro Cys Asn Glu Cys Lys Lys Ala Phe Ala Gln Arg Met
    450                 455                 460                 
Asp Leu Ala Arg His Gln Gln Ile His Thr Gly Arg Lys Pro Phe Ile
465                 470                 475                 480 
Cys Ser Ser Cys Lys Lys Thr Phe Val Arg Leu Ser Asp Leu Thr Gln
                485                 490                 495     
His Lys Gly Thr His Thr Gly Glu Arg Pro Tyr Gln Cys Thr Thr Cys
            500                 505                 510         
Glu Lys Ala Phe Lys Tyr Gln Ser Asn Phe Thr Lys His Gln Lys Thr
        515                 520                 525             
His Ser Ile Gly Arg Pro Phe Thr Cys Asn Glu Cys Gly Lys Thr Phe
    530                 535                 540                 
Arg Leu Asn Trp Lys Leu Asn Gln His Lys Lys Ile His Thr Gly Glu
545                 550                 555                 560 
Lys Pro Tyr Glu Cys Gly Glu Cys Gly Lys Cys Phe Asn Asn Asn Ser
                565                 570                 575     
Asn Leu Ser Lys His Lys Lys Ile His Thr
            580                 585     


<210> 8537
<211> 684
<212> PRT
<213> Homo sapiens

<400> 8537
Met Ser Leu Met Gly His Gly Lys Val Glu Met Leu Leu Tyr Ala Val
 1               5                  10                  15      
Pro Leu Leu Lys Ala Pro Asn Cys Leu Ser Ser Ser Met Gln Leu Pro
            20                  25                  30          
His Gly Gly Gly Arg His Gln Glu Leu Val Arg Phe Arg Asp Val Ala
        35                  40                  45              
Val Val Phe Ser Pro Glu Glu Trp Asp His Leu Thr Pro Glu Gln Arg
    50                  55                  60                  
Asn Leu Tyr Lys Asp Val Met Leu Asp Asn Cys Lys Tyr Leu Ala Ser
65                  70                  75                  80  
Leu Ala Cys Gln Pro Ala Leu Ala Thr Phe Arg Ala Leu Asn Glu Ser
                85                  90                  95      
Gly Asn Ala Phe Arg Gln Ser Phe His His Gly Glu Tyr Arg Thr His
            100                 105                 110         
Arg Thr Phe Val Gln His Tyr Glu Cys Asp Asp Cys Gly Met Ala Phe
        115                 120                 125             
Gly His Val Ser Gln Leu Thr Gly His Gln Lys Ile His Lys Val Gly
    130                 135                 140                 
Glu Thr His Glu Tyr Gly Glu Asn Thr Arg Gly Phe Arg His Arg Ser
145                 150                 155                 160 
Ser Phe Thr Met Leu Gln Arg Ile Cys Thr Leu Tyr Lys His Phe Glu
                165                 170                 175     
Cys Asn Gln Cys Gly Glu Thr Phe Asn Arg Pro Ser Lys Val Ile Gln
            180                 185                 190         
His Gln Ser Met His Ser Gly Leu Lys Pro Tyr Lys Cys Asp Val Cys
        195                 200                 205             
Gln Lys Ala Phe Arg Phe Leu Ser Ser Leu Ser Ile His Gln Arg Phe
    210                 215                 220                 
His Val Gly Asn Arg Val Asn Leu Thr Arg His Gln Lys Thr His Thr
225                 230                 235                 240 
Gln Arg Lys Pro Phe Ser Cys Asn Phe Cys Gly Lys Thr Phe His Arg
                245                 250                 255     
Phe Ser Glu Lys Thr Gln His Leu Leu Ile His Thr Arg Lys Lys Tyr
            260                 265                 270         
Tyr Thr Cys Asn Tyr Cys Lys Lys Glu Phe Asn Pro Tyr Ser Lys Phe
        275                 280                 285             
Ile Leu His Gln Arg Thr His Thr Gly Glu Lys Pro His Lys Cys Asp
    290                 295                 300                 
Val Cys Glu Lys Ser Phe Lys Ser Ile Ser Asn Leu Asn Lys His Gln
305                 310                 315                 320 
Lys Thr His Thr Gly Glu Lys Pro Phe Ser Cys Asn Glu Cys Lys Lys
                325                 330                 335     
Thr Phe Ala Gln Arg Thr Asp Leu Ala Arg His Gln Gln Ile His Thr
            340                 345                 350         
Gly Lys Lys Ser Phe Ile Cys Ser Ser Cys Lys Lys Thr Phe Val Arg
        355                 360                 365             
Leu Ser Asp Leu Thr Gln His Lys Gly Thr His Thr Gly Glu Arg Pro
    370                 375                 380                 
Tyr Gln Cys Thr Thr Cys Glu Lys Ala Phe Lys Tyr Arg Ser Asn Phe
385                 390                 395                 400 
Thr Lys His Gln Lys Thr His Ser Ile Gly Arg Pro Phe Ala Cys Asn
                405                 410                 415     
Glu Cys Gly Lys Thr Tyr Arg Leu Asn Trp Glu Leu Asn Gln His Lys
            420                 425                 430         
Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys Gly Lys
        435                 440                 445             
Arg Phe Asn Asn Asn Ser Asn Leu Asn Lys His Lys Lys Ile His Thr
    450                 455                 460                 
Gly Glu Lys His Phe Val Cys Asn Gln Cys Gly Lys Ala Phe Ser Leu
465                 470                 475                 480 
Asn Ser Lys Leu Ser Arg His Gln Arg Thr His Asn Lys Lys Glu Asn
                485                 490                 495     
Ser Ser Lys Ser Val Ser Asn Leu Asn Lys His Gln Lys Thr His Ala
            500                 505                 510         
Gly Glu Lys Pro Phe Pro Cys Asn Glu Cys Lys Lys Ala Phe Ala Gln
        515                 520                 525             
Arg Met Asp Leu Ala Arg His Gln Gln Ile His Thr Gly Arg Lys Pro
    530                 535                 540                 
Phe Ile Cys Ser Ser Cys Lys Lys Thr Phe Val Arg Leu Ser Asp Leu
545                 550                 555                 560 
Thr Gln His Lys Gly Thr His Thr Gly Glu Arg Pro Tyr Gln Cys Thr
                565                 570                 575     
Thr Cys Glu Lys Ala Phe Lys Tyr Gln Ser Asn Phe Thr Lys His Gln
            580                 585                 590         
Lys Thr His Ser Ile Gly Arg Pro Phe Thr Cys Asn Glu Cys Gly Lys
        595                 600                 605             
Thr Phe Arg Leu Asn Trp Lys Leu Asn Gln His Lys Lys Ile His Thr
    610                 615                 620                 
Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys Gly Lys Cys Phe Asn Asn
625                 630                 635                 640 
Asn Ser Asn Leu Ser Lys His Lys Lys Ile His Thr Gly Glu Lys His
                645                 650                 655     
Phe Val Cys Asn Gln Cys Gly Lys Ala Phe Ser Leu Asn Ser Lys Leu
            660                 665                 670         
Ser Arg His Gln Ile Thr His Asn Lys Lys Lys Pro
        675                 680                 


<210> 8538
<211> 411
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 225, 281, 363
<223> Xaa = Any Amino Acid

<400> 8538
Met Asp Phe Arg Ser Met Gln Gly Gly Ala Ala Leu Gln Ala Gly Glu
 1               5                  10                  15      
Pro Ser Arg Val Thr Pro Val Leu Gly Leu Arg Leu Ala Ser Gly Ile
            20                  25                  30          
Pro Glu Arg Val Val Cys Leu Val Ser Gln Ala Leu Ser His Cys Trp
        35                  40                  45              
Lys Arg Phe Leu Val Phe Leu Asp Leu Arg Pro Glu Gly Arg Phe Gln
    50                  55                  60                  
Gly Asn Gln Glu Glu Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile
65                  70                  75                  80  
Glu Asp Val Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile
                85                  90                  95      
Gln Phe Ser Ala Leu His Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu
            100                 105                 110         
Thr Arg Pro Cys Ile Ala Cys Lys Gln Val Glu Ile Ala His Arg Glu
        115                 120                 125             
Gly Ala Lys Tyr Val Ser His Gly Val Thr Gly Lys Gly Ser Asp Gln
    130                 135                 140                 
Val Gln Phe Glu Leu Asn Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val
145                 150                 155                 160 
Ile Ala Pro Trp Ser Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly His
                165                 170                 175     
Asn Asp Leu Met Glu Tyr Ala Lys His His Gly Ile Pro Ile Leu Val
            180                 185                 190         
Thr Pro Lys Asn Leu Trp Ser Met Asn Lys Asn Leu Met His Ile Ser
        195                 200                 205             
Tyr Glu Ala Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Asp
    210                 215                 220                 
Xaa Val Lys Lys Gly Val Pro Val Lys Val Thr Asp Ile Lys Asp Gly
225                 230                 235                 240 
Ser Thr Tyr Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu Val
                245                 250                 255     
Ala Gly Lys His Gly Val Gly Arg Thr Asp Ile Val Glu Asn Arg Phe
            260                 265                 270         
Ile Gly Met Lys Ser Arg Gly Ile Xaa Glu Ala Pro Ala Gly Thr Ile
        275                 280                 285             
Leu Tyr His Ala His Leu Asp Ile Lys Ala Phe Thr Met Asp Trp Glu
    290                 295                 300                 
Val His Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu Val
305                 310                 315                 320 
Tyr Thr Gly Phe Trp His Ser Thr Glu Cys Glu Phe Ala Cys His Cys
                325                 330                 335     
Phe Ala Lys Ser Gln Glu Pro Val Glu Gly Lys Val Gln Val Ser Val
            340                 345                 350         
Phe Lys Gly Gln Val Tyr Ile Leu Gly Arg Xaa Ser Pro Leu Ser Leu
        355                 360                 365             
Tyr Asn Glu Lys Leu Val Ser Val Asn Met Gln Gly Asp Tyr Glu Pro
    370                 375                 380                 
Ile Asp Ala Thr Gly Phe Ile Asn Ile Ser Ser Leu Arg Leu Lys Glu
385                 390                 395                 400 
Tyr His His Leu Gln Ser Lys Val Thr Ala Lys
                405                 410     


<210> 8539
<211> 336
<212> PRT
<213> Homo sapiens

<400> 8539
Met Ser Gln Ala Val Gln Thr Asn Gly Thr Gln Pro Leu Ser Lys Thr
 1               5                  10                  15      
Trp Glu Leu Ser Leu Tyr Glu Leu Gln Arg Thr Pro Gln Glu Ala Ile
            20                  25                  30          
Thr Asp Gly Leu Glu Ile Val Val Ser Pro Arg Ser Leu His Ser Glu
        35                  40                  45              
Leu Met Cys Pro Ile Cys Leu Asp Met Leu Lys Asn Thr Met Thr Thr
    50                  55                  60                  
Lys Glu Cys Leu His Arg Phe Cys Ala Asp Cys Ile Ile Thr Ala Leu
65                  70                  75                  80  
Arg Ser Gly Asn Lys Glu Cys Pro Thr Cys Arg Lys Lys Leu Val Ser
                85                  90                  95      
Lys Arg Ser Leu Arg Pro Asp Pro Asn Phe Asp Ala Leu Ile Ser Lys
            100                 105                 110         
Ile Tyr Pro Ser Arg Asp Glu Tyr Glu Ala His Gln Glu Arg Val Leu
        115                 120                 125             
Ala Arg Ile Asn Lys His Asn Asn Gln Gln Ala Leu Ser His Ser Ile
    130                 135                 140                 
Glu Glu Gly Leu Lys Ile Gln Ala Met Asn Arg Leu Gln Arg Gly Lys
145                 150                 155                 160 
Lys Gln Gln Ile Glu Asn Gly Ser Gly Ala Glu Asp Asn Gly Asp Ser
                165                 170                 175     
Ser His Cys Ser Asn Ala Ser Thr His Ser Asn Gln Glu Ala Gly Pro
            180                 185                 190         
Ser Asn Lys Arg Thr Lys Thr Ser Asp Asp Ser Gly Leu Glu Leu Asp
        195                 200                 205             
Asn Asn Asn Ala Ala Met Ala Ile Asp Pro Val Met Asp Gly Ala Ser
    210                 215                 220                 
Glu Ile Glu Leu Val Phe Arg Pro His Pro Thr Leu Met Glu Lys Asp
225                 230                 235                 240 
Asp Ser Ala Gln Thr Arg Tyr Ile Lys Thr Ser Gly Asn Ala Thr Val
                245                 250                 255     
Asp His Leu Ser Lys Tyr Leu Ala Val Arg Leu Ala Leu Glu Glu Leu
            260                 265                 270         
Arg Ser Lys Gly Glu Ser Asn Gln Met Asn Leu Asp Thr Ala Ser Glu
        275                 280                 285             
Lys Gln Tyr Thr Ile Tyr Ile Ala Thr Ala Ser Gly Gln Phe Thr Val
    290                 295                 300                 
Leu Asn Gly Ser Phe Ser Leu Glu Leu Val Ser Glu Lys Tyr Trp Lys
305                 310                 315                 320 
Val Asn Lys Pro Met Glu Leu Tyr Tyr Ala Pro Thr Lys Glu His Lys
                325                 330                 335     


<210> 8540
<211> 86
<212> PRT
<213> Homo sapiens

<400> 8540
Met Ala Pro Gln Lys His Gly Gly Gly Gly Gly Gly Gly Ser Gly Pro
 1               5                  10                  15      
Ser Ala Gly Ser Gly Gly Gly Gly Phe Gly Gly Ser Ala Ala Thr Ala
            20                  25                  30          
Ser Ser Gly Lys Ser Gly Gly Gly Gly Cys Gly Gly Gly Gly Ser Tyr
        35                  40                  45              
Ser Ala Ser Ser Ser Ser Ala Ala Leu Pro Val Asn Lys Ser Lys Met
    50                  55                  60                  
Glu His Val Gln Ala Asp His Glu Leu Phe Leu Gln Ala Phe Glu Lys
65                  70                  75                  80  
Ile Gln Gly Phe Arg Leu
                85      


<210> 8541
<211> 527
<212> PRT
<213> Homo sapiens

<400> 8541
Met Gly Lys Arg Gln His Gln Lys Asp Lys Met Tyr Ile Thr Cys Ala
 1               5                  10                  15      
Glu Tyr Thr His Phe Tyr Gly Gly Lys Lys Pro Asp Leu Pro Gln Thr
            20                  25                  30          
Asn Phe Arg Arg Leu Pro Phe Asp His Cys Ser Leu Ser Leu Gln Pro
        35                  40                  45              
Phe Val Tyr Pro Val Cys Thr Pro Asp Gly Ile Val Phe Asp Leu Leu
    50                  55                  60                  
Asn Ile Val Pro Trp Leu Lys Lys Tyr Gly Thr Asn Pro Ser Asn Gly
65                  70                  75                  80  
Glu Lys Leu Asp Gly Arg Ser Leu Ile Lys Leu Asn Phe Ser Lys Asn
                85                  90                  95      
Ser Glu Gly Lys Tyr His Cys Pro Val Leu Phe Thr Val Phe Thr Asn
            100                 105                 110         
Asn Thr His Ile Val Ala Val Arg Thr Thr Gly Asn Val Tyr Ala Tyr
        115                 120                 125             
Glu Ala Val Glu Gln Leu Asn Ile Lys Ala Lys Asn Phe Arg Asp Leu
    130                 135                 140                 
Leu Thr Asp Glu Pro Phe Ser Arg Gln Asp Ile Ile Thr Leu Gln Asp
145                 150                 155                 160 
Pro Thr Asn Leu Asp Lys Phe Asn Val Ser Asn Phe Tyr His Val Lys
                165                 170                 175     
Asn Asn Met Lys Ile Ile Asp Pro Asp Glu Glu Lys Ala Lys Gln Asp
            180                 185                 190         
Pro Ser Tyr Tyr Leu Lys Asn Thr Asn Ala Glu Thr Arg Glu Thr Leu
        195                 200                 205             
Gln Glu Leu Tyr Lys Glu Phe Lys Gly Asp Glu Ile Leu Ala Ala Thr
    210                 215                 220                 
Met Lys Ala Pro Glu Lys Lys Lys Val Asp Lys Leu Asn Ala Ala His
225                 230                 235                 240 
Tyr Ser Thr Gly Lys Val Ser Ala Ser Phe Thr Ser Thr Ala Met Val
                245                 250                 255     
Pro Glu Thr Thr His Glu Ala Ala Ala Ile Asp Glu Asp Val Leu Arg
            260                 265                 270         
Tyr Gln Phe Val Lys Lys Lys Gly Tyr Val Arg Leu His Thr Asn Lys
        275                 280                 285             
Gly Asp Leu Asn Leu Glu Leu His Cys Asp Leu Thr Pro Lys Thr Cys
    290                 295                 300                 
Glu Asn Phe Ile Arg Leu Cys Lys Lys His Tyr Tyr Asp Gly Thr Ile
305                 310                 315                 320 
Phe His Arg Ser Ile Arg Asn Phe Val Ile Gln Gly Gly Asp Pro Thr
                325                 330                 335     
Gly Thr Gly Thr Gly Gly Glu Ser Tyr Trp Gly Lys Pro Phe Lys Asp
            340                 345                 350         
Glu Phe Arg Pro Asn Leu Ser His Thr Gly Arg Gly Ile Leu Ser Met
        355                 360                 365             
Ala Asn Ser Gly Pro Asn Ser Asn Arg Ser Gln Phe Phe Ile Thr Phe
    370                 375                 380                 
Arg Ser Cys Ala Tyr Leu Asp Lys Lys His Thr Ile Phe Gly Arg Val
385                 390                 395                 400 
Val Gly Gly Phe Asp Val Leu Thr Ala Met Glu Asn Val Glu Ser Asp
                405                 410                 415     
Pro Lys Thr Asp Arg Pro Lys Glu Glu Ile Arg Ile Asp Ala Thr Thr
            420                 425                 430         
Val Phe Val Asp Pro Tyr Glu Glu Ala Asp Ala Gln Ile Ala Gln Glu
        435                 440                 445             
Arg Lys Thr Gln Leu Lys Val Ala Pro Glu Thr Lys Val Lys Ser Ser
    450                 455                 460                 
Gln Pro Gln Ala Gly Ser Gln Gly Pro Gln Thr Phe Arg Gln Gly Val
465                 470                 475                 480 
Gly Lys Tyr Ile Asn Pro Ala Ala Thr Glu Gln Gln Arg Lys Ser Pro
                485                 490                 495     
Gln Pro Val Pro Leu Ser Pro Cys Pro Arg Arg Ser Pro Val Gly Val
            500                 505                 510         
Leu Gly Thr Ser Ala Pro Gly Ser Ser Arg Leu Pro Asp Asp His
        515                 520                 525         


<210> 8542
<211> 350
<212> PRT
<213> Homo sapiens

<400> 8542
Phe Arg Asn Ile Val Pro Trp Leu Lys Lys Tyr Gly Thr Asn Pro Ser
 1               5                  10                  15      
Asn Gly Glu Lys Leu Asp Gly Arg Ser Leu Ile Lys Leu Asn Phe Ser
            20                  25                  30          
Lys Asn Ser Glu Gly Lys Tyr His Cys Pro Val Leu Phe Thr Val Phe
        35                  40                  45              
Thr Asn Asn Thr His Ile Val Ala Val Arg Thr Thr Gly Asn Val Tyr
    50                  55                  60                  
Ala Tyr Glu Ala Val Glu Gln Leu Asn Ile Lys Ala Lys Asn Phe Arg
65                  70                  75                  80  
Asp Leu Leu Thr Asp Glu Pro Phe Ser Arg Gln Asp Ile Ile Thr Leu
                85                  90                  95      
Gln Val Ser Val Pro Cys Leu Pro Ala Pro Ala Ala Phe Ser Thr Cys
            100                 105                 110         
Ser Gln Pro Arg Pro Leu Gln Gly Pro Thr Pro Thr Gly Gly Val Trp
        115                 120                 125             
Leu Ala Ser Arg Gln Ala Thr Arg Pro His Pro Thr Ala Ser His Gly
    130                 135                 140                 
Thr Ala Glu Val Pro Pro Trp Phe Pro Trp Gln Ala His Tyr Ser Thr
145                 150                 155                 160 
Gly Lys Val Ser Ala Ser Phe Thr Ser Thr Ala Met Val Pro Glu Thr
                165                 170                 175     
Thr His Glu Ala Gly Ala Glu Leu Gly Pro Trp Leu Val Ala Ala Ile
            180                 185                 190         
Asp Glu Asp Val Leu Arg Tyr Gln Phe Val Lys Lys Lys Gly Tyr Val
        195                 200                 205             
Arg Leu His Thr Asn Lys Gly Asp Leu Asn Leu Glu Leu His Cys Asp
    210                 215                 220                 
Leu Thr Pro Lys Thr Cys Glu Asn Phe Ile Arg Leu Cys Lys Lys His
225                 230                 235                 240 
Tyr Tyr Asp Gly Thr Ile Phe His Arg Ser Ile Arg Asn Phe Val Ile
                245                 250                 255     
Gln Gly Gly Asp Pro Thr Gly Thr Gly Thr Gly Gly Glu Ser Tyr Trp
            260                 265                 270         
Gly Lys Pro Phe Lys Asp Glu Phe Arg Pro Asn Leu Ser His Thr Gly
        275                 280                 285             
Arg Gly Ile Leu Ser Met Ala Asn Ser Gly Pro Asn Ser Asn Arg Ser
    290                 295                 300                 
Gln Phe Phe Ile Thr Phe Arg Ser Cys Ala Tyr Leu Asp Lys Lys His
305                 310                 315                 320 
Thr Ile Phe Gly Arg Val Val Gly Gly Phe Asp Val Leu Thr Ala Met
                325                 330                 335     
Glu Asn Val Glu Ser Asp Pro Lys Thr Asp Arg Pro Lys Val
            340                 345                 350 


<210> 8543
<211> 520
<212> PRT
<213> Homo sapiens

<400> 8543
Met Gly Lys Arg Gln His Gln Lys Asp Lys Met Tyr Ile Thr Cys Ala
 1               5                  10                  15      
Glu Tyr Thr His Phe Tyr Gly Gly Lys Lys Pro Asp Leu Pro Gln Thr
            20                  25                  30          
Asn Phe Arg Arg Leu Pro Phe Asp His Cys Ser Leu Ser Leu Gln Pro
        35                  40                  45              
Phe Val Tyr Pro Val Cys Thr Pro Asp Gly Ile Val Phe Asp Leu Leu
    50                  55                  60                  
Asn Ile Val Pro Trp Leu Lys Lys Tyr Gly Thr Asn Pro Ser Asn Gly
65                  70                  75                  80  
Glu Lys Leu Asp Gly Arg Ser Leu Ile Lys Leu Asn Phe Ser Lys Asn
                85                  90                  95      
Ser Glu Gly Lys Tyr His Cys Pro Val Leu Phe Thr Val Phe Thr Asn
            100                 105                 110         
Asn Thr His Ile Val Ala Val Arg Thr Thr Gly Asn Val Tyr Ala Tyr
        115                 120                 125             
Glu Ala Val Glu Gln Leu Asn Ile Lys Ala Lys Asn Phe Arg Asp Leu
    130                 135                 140                 
Leu Thr Asp Glu Pro Phe Ser Arg Gln Asp Ile Ile Thr Leu Gln Asp
145                 150                 155                 160 
Pro Thr Asn Leu Asp Lys Phe Asn Val Ser Asn Phe Tyr His Val Lys
                165                 170                 175     
Asn Asn Met Lys Ile Ile Asp Pro Asp Glu Glu Lys Ala Lys Gln Asp
            180                 185                 190         
Pro Ser Tyr Tyr Leu Lys Asn Thr Asn Ala Glu Thr Arg Glu Thr Leu
        195                 200                 205             
Gln Glu Leu Tyr Lys Glu Phe Lys Gly Asp Glu Ile Leu Ala Ala Thr
    210                 215                 220                 
Met Lys Ala Pro Glu Lys Lys Lys Val Asp Lys Leu Asn Ala Ala His
225                 230                 235                 240 
Tyr Ser Thr Gly Lys Val Ser Ala Ser Phe Thr Ser Thr Ala Met Val
                245                 250                 255     
Pro Glu Thr Thr His Glu Ala Ala Ala Ile Asp Glu Asp Val Leu Arg
            260                 265                 270         
Tyr Gln Phe Val Lys Lys Lys Gly Tyr Val Arg Leu His Thr Asn Lys
        275                 280                 285             
Gly Asp Leu Asn Leu Glu Leu His Cys Asp Leu Thr Pro Lys Thr Cys
    290                 295                 300                 
Glu Asn Phe Ile Arg Leu Cys Lys Lys His Tyr Tyr Asp Gly Thr Ile
305                 310                 315                 320 
Phe His Arg Ser Ile Arg Asn Phe Val Ile Gln Gly Gly Asp Pro Thr
                325                 330                 335     
Gly Thr Gly Thr Gly Gly Glu Ser Tyr Trp Gly Lys Pro Phe Lys Asp
            340                 345                 350         
Glu Phe Arg Pro Asn Leu Ser His Thr Gly Arg Gly Ile Leu Ser Met
        355                 360                 365             
Ala Asn Ser Gly Pro Asn Ser Asn Arg Ser Gln Phe Phe Ile Thr Phe
    370                 375                 380                 
Arg Ser Cys Ala Tyr Leu Asp Lys Lys His Thr Ile Phe Gly Arg Val
385                 390                 395                 400 
Val Gly Gly Phe Asp Val Leu Thr Ala Met Glu Asn Val Glu Ser Asp
                405                 410                 415     
Pro Lys Thr Asp Arg Pro Lys Glu Glu Ile Arg Ile Asp Ala Thr Thr
            420                 425                 430         
Val Phe Val Asp Pro Tyr Glu Glu Ala Asp Ala Gln Ile Ala Gln Glu
        435                 440                 445             
Arg Lys Thr Gln Leu Lys Val Ala Pro Glu Thr Lys Val Lys Ser Ser
    450                 455                 460                 
Gln Pro Gln Ala Gly Ser Gln Gly Pro Gln Thr Phe Arg Gln Gly Val
465                 470                 475                 480 
Gly Lys Tyr Ile Asn Pro Ala Ala Thr Lys Arg Ala Ala Glu Glu Glu
                485                 490                 495     
Pro Ser Thr Ser Ala Thr Val Pro Met Ser Lys Lys Lys Pro Ser Arg
            500                 505                 510         
Gly Phe Gly Asp Phe Ser Ser Trp
        515                 520 


<210> 8544
<211> 402
<212> PRT
<213> Homo sapiens

<400> 8544
Thr Asp Leu Pro Gln Thr Asn Phe Arg Arg Leu Pro Phe Asp His Cys
 1               5                  10                  15      
Ser Leu Ser Leu Gln Pro Phe Val Tyr Pro Val Cys Thr Pro Asp Gly
            20                  25                  30          
Ile Val Phe Asp Leu Leu Asn Ile Val Pro Trp Leu Lys Lys Tyr Gly
        35                  40                  45              
Thr Asn Pro Ser Asn Gly Glu Pro Thr Glu Val Thr Gly Leu Pro Val
    50                  55                  60                  
Cys Ala Phe Ser Leu Gly Lys Tyr His Cys Pro Val Leu Phe Thr Val
65                  70                  75                  80  
Phe Thr Asn Asn Thr His Ile Val Ala Val Arg Thr Thr Gly Asn Val
                85                  90                  95      
Tyr Ala Tyr Glu Ala Val Glu Gln Leu Asn Ile Lys Ala Lys Asn Phe
            100                 105                 110         
Arg Asp Leu Leu Thr Asp Glu Pro Phe Ser Arg Gln Asp Ile Ile Thr
        115                 120                 125             
Leu Gln Asp Pro Thr Asn Leu Asp Lys Phe Asn Val Ser Asn Phe Tyr
    130                 135                 140                 
His Val Lys Asn Asn Met Lys Ile Ile Asp Pro Gly Pro Cys Tyr Cys
145                 150                 155                 160 
Phe Val Asp Glu Glu Lys Ala Lys Gln Asp Pro Ser Tyr Tyr Leu Lys
                165                 170                 175     
Asn Thr Asn Ala Glu Thr Arg Glu Thr Leu Gln Glu Leu Tyr Lys Glu
            180                 185                 190         
Phe Lys Gly Asp Glu Ile Leu Ala Ala Thr Met Lys Ala Pro Glu Lys
        195                 200                 205             
Lys Lys Val Asp Lys Leu Asn Ala Ala His Tyr Ser Thr Gly Lys Val
    210                 215                 220                 
Ser Ala Ser Phe Thr Ser Thr Ala Met Val Pro Glu Thr Thr His Glu
225                 230                 235                 240 
Ala Ala Ala Ile Asp Glu Asp Val Leu Arg Tyr Gln Phe Val Lys Lys
                245                 250                 255     
Lys Gly Tyr Val Arg Leu His Thr Asn Lys Gly Asp Leu Asn Leu Glu
            260                 265                 270         
Leu His Cys Asp Leu Thr Pro Lys Thr Cys Glu Asn Phe Ile Arg Leu
        275                 280                 285             
Cys Lys Lys His Tyr Tyr Asp Gly Thr Ile Phe His Arg Ser Ile Arg
    290                 295                 300                 
Asn Phe Val Ile Gln Gly Gly Asp Pro Thr Gly Thr Gly Thr Gly Gly
305                 310                 315                 320 
Glu Ser Tyr Trp Gly Lys Pro Phe Lys Asp Glu Phe Arg Pro Asn Leu
                325                 330                 335     
Ser His Thr Gly Arg Gly Ile Leu Ser Met Ala Asn Ser Gly Pro Asn
            340                 345                 350         
Ser Asn Arg Ser Gln Phe Phe Ile Thr Phe Arg Ser Cys Ala Tyr Leu
        355                 360                 365             
Asp Lys Lys His Thr Ile Phe Gly Arg Val Val Gly Gly Phe Asp Val
    370                 375                 380                 
Leu Thr Ala Met Glu Asn Val Glu Ser Asp Pro Lys Thr Asp Arg Pro
385                 390                 395                 400 
Lys Val
        


<210> 8545
<211> 1054
<212> PRT
<213> Homo sapiens

<400> 8545
Met Ala Arg Leu Arg Gly Gly Arg Ile Pro Ala Met Pro Gln Pro Ser
 1               5                  10                  15      
Pro Gly Gln Pro Ala Gly Thr Gln Trp Cys Phe Gln Gly Thr Val Phe
            20                  25                  30          
Ala Leu Gln Leu Arg Asp Phe His Ser Val Leu Gln Met Val Leu Glu
        35                  40                  45              
Glu Val Pro Glu Pro Val Ser Ser Glu Ala Glu Ser Leu Gly His Ser
    50                  55                  60                  
Ser Tyr Ser Val Asp Asp Val Ile Val Leu Glu Ile Glu Val Lys Gly
65                  70                  75                  80  
Ser Val Glu Pro Phe Gln Val Leu Leu Glu Pro Tyr Ala Leu Ile Ile
                85                  90                  95      
Pro Gly Glu Asn Tyr Ile Gly Ile Asn Val Lys Lys Ala Phe Lys Met
            100                 105                 110         
Trp Asn Asn Ser Lys Ser Pro Ile Arg Tyr Leu Trp Gly Lys Ile Ser
        115                 120                 125             
Asp Cys His Ile Ile Glu Val Glu Pro Gly Thr Gly Val Ile Glu Pro
    130                 135                 140                 
Ser Glu Val Gly Asp Phe Glu Leu Asn Phe Thr Gly Gly Val Pro Gly
145                 150                 155                 160 
Pro Thr Ser Gln Asp Leu Leu Cys Glu Ile Glu Asp Ser Pro Ser Pro
                165                 170                 175     
Val Val Leu His Ile Glu Ala Val Phe Lys Pro Phe Ser Leu Val Cys
            180                 185                 190         
Ser Ala Trp Gly Arg Lys Pro Gln Thr Pro Ser Arg Ser Gly Thr Ser
        195                 200                 205             
Ala Ser Ser Gln Pro His Gly Met Lys Glu Ser Pro Val Ser Leu Gln
    210                 215                 220                 
Glu Arg Pro Glu Asp Val Ser Pro Phe Asp Ile Glu Pro Ser Ser Gly
225                 230                 235                 240 
Gln Leu His Ser Leu Gly Glu Cys Arg Val Asp Ile Thr Leu Glu Ala
                245                 250                 255     
Leu His Cys Gln His Leu Glu Thr Val Leu Glu Leu Glu Val Glu Asn
            260                 265                 270         
Gly Ala Trp Ser Tyr Leu Pro Val Tyr Ala Glu Val Gln Lys Pro His
        275                 280                 285             
Val Tyr Leu Gln Ser Ser Gln Val Glu Val Arg Asn Leu Tyr Leu Gly
    290                 295                 300                 
Val Pro Thr Lys Thr Thr Ile Thr Leu Ile Asn Gly Thr Leu Leu Pro
305                 310                 315                 320 
Thr Gln Phe His Trp Gly Lys Leu Leu Gly His Gln Ala Glu Phe Cys
                325                 330                 335     
Met Val Thr Val Ser Pro Lys His Gly Leu Leu Gly Pro Ser Glu Glu
            340                 345                 350         
Cys Gln Leu Lys Leu Glu Leu Thr Ala His Thr Gln Glu Glu Leu Thr
        355                 360                 365             
His Leu Ala Leu Pro Cys His Val Ser Gly Met Lys Lys Pro Leu Val
    370                 375                 380                 
Leu Gly Ile Ser Gly Lys Pro Gln Gly Leu Gln Val Ala Ile Thr Ile
385                 390                 395                 400 
Ser Lys Glu Ser Ser Asp Cys Ser Thr Glu Gln Trp Pro Gly His Pro
                405                 410                 415     
Lys Glu Leu Arg Leu Asp Phe Gly Ser Ala Val Pro Leu Arg Thr Arg
            420                 425                 430         
Val Thr Arg Gln Leu Ile Leu Thr Asn Arg Ser Pro Ile Arg Thr Arg
        435                 440                 445             
Phe Ser Leu Lys Phe Glu Tyr Phe Gly Ser Pro Gln Asn Ser Leu Ser
    450                 455                 460                 
Lys Lys Thr Ser Leu Pro Asn Met Pro Pro Ala Leu Leu Lys Thr Val
465                 470                 475                 480 
Arg Met Gln Glu His Leu Ala Lys Arg Glu Gln Leu Gly Cys Ala Asn
                485                 490                 495     
Met Trp Gly Glu Tyr Trp Asp Asn Leu Ile Cys Thr Val Gly Asp Leu
            500                 505                 510         
Leu Pro Glu Val Ile Pro Val His Met Ala Ala Val Gly Cys Pro Ile
        515                 520                 525             
Ser Ser Leu Arg Thr Thr Ser Tyr Thr Ile Asp Gln Ala Gln Lys Glu
    530                 535                 540                 
Pro Ala Met Arg Phe Gly Thr Gln Val Ser Gly Gly Asp Thr Val Thr
545                 550                 555                 560 
Arg Thr Leu Arg Leu Asn Asn Ser Ser Pro Cys Asp Ile Arg Leu Asp
                565                 570                 575     
Trp Glu Thr Tyr Val Pro Glu Asp Lys Glu Asp Arg Leu Val Glu Leu
            580                 585                 590         
Leu Val Phe Tyr Gly Pro Pro Phe Pro Leu Arg Asp Gln Ala Gly Asn
        595                 600                 605             
Glu Leu Val Cys Pro Asp Thr Pro Glu Gly Gly Cys Leu Leu Trp Ser
    610                 615                 620                 
Pro Gly Pro Ser Ser Ser Ser Glu Phe Ser His Glu Thr Asp Ser Ser
625                 630                 635                 640 
Val Glu Gly Ser Ser Ser Ala Ser Asn Arg Val Ala Gln Lys Leu Ile
                645                 650                 655     
Ser Val Ile Leu Gln Ala His Glu Gly Val Pro Ser Gly His Leu Tyr
            660                 665                 670         
Cys Ile Ser Pro Lys Gln Val Val Val Pro Ala Gly Gly Ser Ser Thr
        675                 680                 685             
Ile Tyr Ile Ser Phe Thr Pro Met Val Leu Ser Pro Glu Ile Leu His
    690                 695                 700                 
Lys Val Glu Cys Thr Gly Tyr Ala Leu Gly Phe Met Ser Leu Asp Ser
705                 710                 715                 720 
Lys Val Glu Arg Glu Ile Pro Gly Lys Arg His Arg Leu Gln Asp Phe
                725                 730                 735     
Ala Val Gly Pro Leu Lys Leu Asp Leu His Ser Tyr Val Arg Pro Ala
            740                 745                 750         
Gln Leu Ser Val Glu Leu Asp Tyr Gly Gly Ser Met Glu Phe Gln Cys
        755                 760                 765             
Gln Ala Ser Asp Leu Ile Pro Glu Gln Pro Cys Ser Gly Val Leu Ser
    770                 775                 780                 
Glu Leu Val Thr Thr His His Leu Lys Leu Thr Asn Thr Thr Glu Ile
785                 790                 795                 800 
Pro His Tyr Phe Arg Leu Met Val Ser Arg Pro Phe Ser Val Ser Gln
                805                 810                 815     
Asp Gly Ala Ser Gln Asp His Arg Ala Pro Gly Pro Gly Gln Lys Gln
            820                 825                 830         
Glu Cys Glu Glu Glu Thr Ala Ser Ala Asp Lys Gln Leu Val Leu Gln
        835                 840                 845             
Ala Gln Glu Asn Met Leu Val Asn Val Ser Phe Ser Leu Ser Leu Glu
    850                 855                 860                 
Leu Leu Ser Tyr Gln Lys Leu Pro Ala Asp Gln Thr Leu Pro Gly Val
865                 870                 875                 880 
Asp Ile Gln Gln Ser Ala Ser Gly Glu Arg Glu Met Val Phe Thr Gln
                885                 890                 895     
Asn Leu Leu Leu Glu Tyr Thr Asn Gln Thr Thr Gln Ala Arg Pro Arg
            900                 905                 910         
Pro Thr Tyr Met Trp Arg Arg Val Glu Val Val Pro Leu Arg Ala Val
        915                 920                 925             
Val Ala Val Pro Glu Leu Gln Leu Ser Thr Ser Trp Val Asp Phe Gly
    930                 935                 940                 
Thr Cys Phe Val Ser Gln Gln Arg Val Arg Glu Val Tyr Leu Met Asn
945                 950                 955                 960 
Leu Ser Gly Cys Arg Ser Tyr Trp Thr Met Leu Met Gly Gln Gln Glu
                965                 970                 975     
Pro Ala Lys Ala Ala Val Ala Phe Arg Val Ser Pro Asn Ser Gly Leu
            980                 985                 990         
Leu Glu Ala Arg Ser Ala Asn Ala Pro Pro Thr Ser Ile Ala Leu Gln
        995                 1000                1005            
Val Phe Phe Thr Ala Arg Ser Ser Glu Leu Tyr Glu Ser Thr Met Val
    1010                1015                1020                
Val Glu Gly Val Leu Gly Glu Lys Ser Cys Thr Leu Arg Leu Arg Gly
1025                1030                1035                1040
Gln Gly Ser Tyr Asp Glu Arg Tyr Met Leu Pro His Gln Pro
                1045                1050                


<210> 8546
<211> 1262
<212> PRT
<213> Homo sapiens

<400> 8546
Met Glu Asp Gly Lys Pro Val Trp Ala Pro His Pro Thr Asp Gly Phe
 1               5                  10                  15      
Gln Met Gly Asn Ile Val Asp Ile Gly Pro Asp Ser Leu Thr Ile Glu
            20                  25                  30          
Pro Leu Asn Gln Lys Gly Lys Thr Phe Leu Ala Leu Ile Asn Gln Val
        35                  40                  45              
Phe Pro Ala Glu Glu Asp Ser Lys Lys Asp Val Glu Asp Asn Cys Ser
    50                  55                  60                  
Leu Met Tyr Leu Asn Glu Ala Thr Leu Leu His Asn Ile Lys Val Arg
65                  70                  75                  80  
Tyr Ser Lys Asp Arg Ile Tyr Thr Tyr Val Ala Asn Ile Leu Ile Ala
                85                  90                  95      
Val Asn Pro Tyr Phe Asp Ile Pro Lys Ile Tyr Ser Ser Glu Ala Ile
            100                 105                 110         
Lys Ser Tyr Gln Gly Lys Ser Leu Gly Thr Arg Pro Pro His Val Phe
        115                 120                 125             
Ala Ile Ala Asp Lys Ala Phe Arg Asp Met Lys Val Leu Lys Met Ser
    130                 135                 140                 
Gln Ser Ile Ile Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn
145                 150                 155                 160 
Thr Lys Phe Val Leu Arg Tyr Leu Thr Glu Ser Tyr Gly Thr Gly Gln
                165                 170                 175     
Asp Ile Asp Asp Arg Ile Val Glu Ala Asn Pro Leu Leu Glu Ala Phe
            180                 185                 190         
Gly Asn Ala Lys Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys
        195                 200                 205             
Phe Val Glu Ile His Phe Asn Glu Lys Ser Ser Val Val Gly Gly Phe
    210                 215                 220                 
Val Ser His Tyr Leu Leu Glu Lys Ser Arg Ile Cys Val Gln Gly Lys
225                 230                 235                 240 
Glu Glu Arg Asn Tyr His Ile Phe Tyr Arg Leu Cys Ala Gly Ala Ser
                245                 250                 255     
Glu Asp Ile Arg Glu Lys Leu His Leu Ser Ser Pro Asp Asn Phe Arg
            260                 265                 270         
Tyr Leu Asn Arg Gly Cys Thr Arg Tyr Phe Ala Asn Lys Glu Thr Asp
        275                 280                 285             
Lys Gln Ile Leu Gln Asn Arg Lys Ser Pro Glu Tyr Leu Lys Ala Gly
    290                 295                 300                 
Ser Met Lys Asp Pro Leu Leu Asp Asp His Gly Asp Phe Ile Arg Met
305                 310                 315                 320 
Cys Thr Ala Met Lys Lys Ile Gly Leu Asp Asp Glu Glu Lys Leu Asp
                325                 330                 335     
Leu Phe Arg Val Val Ala Gly Val Leu His Leu Gly Asn Ile Asp Phe
            340                 345                 350         
Glu Glu Ala Gly Ser Thr Ser Gly Gly Cys Asn Leu Lys Asn Lys Ser
        355                 360                 365             
Ala Gln Ser Leu Glu Tyr Cys Ala Glu Leu Leu Gly Leu Asp Gln Asp
    370                 375                 380                 
Asp Leu Arg Val Ser Leu Thr Thr Arg Val Met Leu Thr Thr Ala Gly
385                 390                 395                 400 
Gly Thr Lys Gly Thr Val Ile Lys Val Pro Leu Lys Val Glu Gln Ala
                405                 410                 415     
Asn Asn Ala Arg Asp Ala Leu Ala Lys Thr Val Tyr Ser His Leu Phe
            420                 425                 430         
Asp His Val Val Asn Arg Val Asn Gln Cys Phe Pro Phe Glu Thr Ser
        435                 440                 445             
Ser Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Tyr Phe Glu
    450                 455                 460                 
His Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu
465                 470                 475                 480 
Gln Gln Phe Phe Asn Glu Arg Ile Leu Lys Glu Glu Gln Glu Leu Tyr
                485                 490                 495     
Gln Lys Glu Gly Leu Gly Val Asn Glu Val His Tyr Val Asp Asn Gln
            500                 505                 510         
Asp Cys Ile Asp Leu Ile Glu Ala Lys Leu Val Gly Ile Leu Asp Ile
        515                 520                 525             
Leu Asp Glu Glu Asn Arg Leu Pro Gln Pro Ser Asp Gln His Phe Thr
    530                 535                 540                 
Ser Ala Val His Gln Lys His Lys Asp His Phe Arg Leu Thr Ile Pro
545                 550                 555                 560 
Arg Lys Ser Lys Leu Ala Val His Arg Asn Ile Arg Asp Asp Glu Gly
                565                 570                 575     
Phe Ile Ile Arg His Phe Ala Gly Ala Val Cys Tyr Glu Thr Thr Gln
            580                 585                 590         
Phe Val Glu Lys Asn Asn Asp Ala Leu His Met Ser Leu Glu Ser Leu
        595                 600                 605             
Ile Cys Glu Ser Arg Asp Lys Phe Ile Arg Glu Leu Phe Glu Ser Ser
    610                 615                 620                 
Thr Asn Asn Asn Lys Asp Thr Lys Gln Lys Ala Gly Lys Leu Ser Phe
625                 630                 635                 640 
Ile Ser Val Gly Asn Lys Phe Lys Thr Gln Leu Asn Leu Leu Leu Asp
                645                 650                 655     
Lys Leu Arg Ser Thr Gly Ala Ser Phe Ile Arg Cys Ile Lys Pro Asn
            660                 665                 670         
Leu Lys Met Thr Ser His His Phe Glu Gly Ala Gln Ile Leu Ser Gln
        675                 680                 685             
Leu Gln Cys Ser Gly Met Val Ser Val Leu Asp Leu Met Gln Gly Gly
    690                 695                 700                 
Tyr Pro Ser Arg Ala Ser Phe His Glu Leu Tyr Asn Met Tyr Lys Lys
705                 710                 715                 720 
Tyr Met Pro Asp Lys Leu Ala Arg Leu Asp Pro Arg Leu Phe Cys Lys
                725                 730                 735     
Ala Leu Phe Lys Ala Leu Gly Leu Asn Glu Asn Asp Tyr Lys Phe Gly
            740                 745                 750         
Leu Thr Lys Val Phe Phe Arg Pro Gly Lys Phe Ala Glu Phe Asp Gln
        755                 760                 765             
Ile Met Lys Ser Asp Pro Asp His Leu Ala Glu Leu Val Lys Arg Val
    770                 775                 780                 
Asn His Trp Leu Thr Cys Ser Arg Trp Lys Lys Val Gln Trp Cys Ser
785                 790                 795                 800 
Leu Ser Val Ile Lys Leu Lys Asn Lys Ile Lys Tyr Arg Ala Glu Ala
                805                 810                 815     
Cys Ile Lys Met Gln Lys Thr Ile Arg Met Trp Leu Cys Lys Arg Arg
            820                 825                 830         
His Lys Pro Arg Ile Asp Gly Leu Val Lys Val Gly Thr Leu Lys Lys
        835                 840                 845             
Arg Leu Asp Lys Phe Asn Glu Val Val Ser Val Leu Lys Asp Gly Lys
    850                 855                 860                 
Pro Glu Met Asn Lys Gln Ile Lys Asn Leu Glu Ile Ser Ile Asp Thr
865                 870                 875                 880 
Leu Met Ala Lys Ile Lys Ser Thr Met Met Thr Gln Glu Gln Ile Gln
                885                 890                 895     
Lys Glu Tyr Asp Ala Leu Val Lys Ser Ser Glu Glu Leu Leu Ser Ala
            900                 905                 910         
Leu Gln Lys Lys Lys Gln Gln Glu Glu Glu Ala Glu Arg Leu Arg Arg
        915                 920                 925             
Ile Gln Glu Glu Met Glu Lys Glu Arg Lys Arg Arg Glu Glu Asp Glu
    930                 935                 940                 
Lys Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Met Lys Leu Glu Met
945                 950                 955                 960 
Glu Ala Lys Arg Lys Gln Glu Glu Glu Glu Arg Lys Lys Arg Glu Asp
                965                 970                 975     
Asp Glu Lys Arg Ile Gln Ala Glu Val Glu Ala Gln Leu Ala Arg Gln
            980                 985                 990         
Lys Glu Glu Glu Ser Gln Gln Gln Ala Val Leu Glu Gln Glu Arg Arg
        995                 1000                1005            
Asp Arg Glu Leu Ala Leu Arg Ile Ala Gln Ser Glu Ala Glu Leu Ile
    1010                1015                1020                
Ser Asp Glu Ala Gln Ala Asp Leu Ala Leu Arg Arg Gly Pro Ala Val
1025                1030                1035                1040
Leu Ala Thr Lys Ala Ala Ala Gly Thr Lys Lys Tyr Asp Leu Ser Lys
                1045                1050                1055    
Trp Lys Tyr Ala Glu Leu Arg Asp Thr Ile Asn Thr Ser Cys Asp Ile
            1060                1065                1070        
Glu Leu Leu Ala Ala Cys Arg Glu Glu Phe His Arg Arg Leu Lys Val
        1075                1080                1085            
Tyr His Ala Trp Lys Ser Lys Asn Lys Lys Arg Asn Thr Glu Thr Glu
    1090                1095                1100                
Gln Arg Ala Pro Lys Ser Val Thr Asp Tyr Asp Phe Ala Pro Phe Leu
1105                1110                1115                1120
Asn Asn Ser Pro Gln Gln Asn Pro Ala Ala Gln Ile Pro Ala Arg Gln
                1125                1130                1135    
Arg Glu Ile Glu Met Asn Arg Gln Gln Arg Phe Phe Arg Ile Pro Phe
            1140                1145                1150        
Ile Arg Pro Ala Asp Gln Tyr Lys Asp Pro Gln Ser Lys Lys Lys Gly
        1155                1160                1165            
Trp Trp Tyr Ala His Phe Asp Gly Pro Trp Ile Ala Arg Gln Met Glu
    1170                1175                1180                
Leu His Pro Asp Lys Pro Pro Ile Leu Leu Val Ala Gly Lys Asp Asp
1185                1190                1195                1200
Met Glu Met Cys Glu Leu Asn Leu Glu Glu Thr Gly Leu Thr Arg Lys
                1205                1210                1215    
Arg Gly Ala Glu Ile Leu Pro Arg Gln Phe Glu Glu Ile Trp Glu Arg
            1220                1225                1230        
Cys Gly Gly Ile Gln Tyr Leu Gln Asn Ala Ile Glu Ser Arg Gln Ala
        1235                1240                1245            
Arg Pro Thr Tyr Ala Thr Ala Met Leu Gln Ser Leu Leu Lys
    1250                1255                1260        


<210> 8547
<211> 1285
<212> PRT
<213> Homo sapiens

<400> 8547
Met Glu Asp Gly Lys Pro Val Trp Ala Pro His Pro Thr Asp Gly Phe
 1               5                  10                  15      
Gln Met Gly Asn Ile Val Asp Ile Gly Pro Asp Ser Leu Thr Ile Glu
            20                  25                  30          
Pro Leu Asn Gln Lys Gly Lys Thr Phe Leu Ala Leu Ile Asn Gln Val
        35                  40                  45              
Phe Pro Ala Glu Glu Asp Ser Lys Lys Asp Val Glu Asp Asn Cys Ser
    50                  55                  60                  
Leu Met Tyr Leu Asn Glu Ala Thr Leu Leu His Asn Ile Lys Val Arg
65                  70                  75                  80  
Tyr Ser Lys Asp Arg Ile Tyr Thr Tyr Val Ala Asn Ile Leu Ile Ala
                85                  90                  95      
Val Asn Pro Tyr Phe Asp Ile Pro Lys Ile Tyr Ser Ser Glu Ala Ile
            100                 105                 110         
Lys Ser Tyr Gln Gly Lys Ser Leu Gly Thr Arg Pro Pro His Val Phe
        115                 120                 125             
Ala Ile Ala Asp Lys Ala Phe Arg Asp Met Lys Val Leu Lys Met Ser
    130                 135                 140                 
Gln Ser Ile Ile Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn
145                 150                 155                 160 
Thr Lys Phe Val Leu Arg Tyr Leu Thr Glu Ser Tyr Gly Thr Gly Gln
                165                 170                 175     
Asp Ile Asp Asp Arg Ile Val Glu Ala Asn Pro Leu Leu Glu Ala Phe
            180                 185                 190         
Gly Asn Ala Lys Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys
        195                 200                 205             
Phe Val Glu Ile His Phe Asn Glu Lys Ser Ser Val Val Gly Gly Phe
    210                 215                 220                 
Val Ser His Tyr Leu Leu Glu Lys Ser Arg Ile Cys Val Gln Gly Lys
225                 230                 235                 240 
Glu Glu Arg Asn Tyr His Ile Phe Tyr Arg Leu Cys Ala Gly Ala Ser
                245                 250                 255     
Glu Asp Ile Arg Glu Lys Leu His Leu Ser Ser Pro Asp Asn Phe Arg
            260                 265                 270         
Tyr Leu Asn Arg Gly Cys Thr Arg Tyr Phe Ala Asn Lys Glu Thr Asp
        275                 280                 285             
Lys Gln Ile Leu Gln Asn Arg Lys Ser Pro Glu Tyr Leu Lys Ala Gly
    290                 295                 300                 
Ser Met Lys Asp Pro Leu Leu Asp Asp His Gly Asp Phe Ile Arg Met
305                 310                 315                 320 
Cys Thr Ala Met Lys Lys Ile Gly Leu Asp Asp Glu Glu Lys Leu Asp
                325                 330                 335     
Leu Phe Arg Val Val Ala Gly Val Leu His Leu Gly Asn Ile Asp Phe
            340                 345                 350         
Glu Glu Ala Gly Ser Thr Ser Gly Gly Cys Asn Leu Lys Asn Lys Ser
        355                 360                 365             
Ala Gln Ser Leu Glu Tyr Cys Ala Glu Leu Leu Gly Leu Asp Gln Asp
    370                 375                 380                 
Asp Leu Arg Val Ser Leu Thr Thr Arg Val Met Leu Thr Thr Ala Gly
385                 390                 395                 400 
Gly Thr Lys Gly Thr Val Ile Lys Val Pro Leu Lys Val Glu Gln Ala
                405                 410                 415     
Asn Asn Ala Arg Asp Ala Leu Ala Lys Thr Val Tyr Ser His Leu Phe
            420                 425                 430         
Asp His Val Val Asn Arg Val Asn Gln Cys Phe Pro Phe Glu Thr Ser
        435                 440                 445             
Ser Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Tyr Phe Glu
    450                 455                 460                 
His Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu
465                 470                 475                 480 
Gln Gln Phe Phe Asn Glu Arg Ile Leu Lys Glu Glu Gln Glu Leu Tyr
                485                 490                 495     
Gln Lys Glu Gly Leu Gly Val Asn Glu Val His Tyr Val Asp Asn Gln
            500                 505                 510         
Asp Cys Ile Asp Leu Ile Glu Ala Lys Leu Val Gly Ile Leu Asp Ile
        515                 520                 525             
Leu Asp Glu Glu Asn Arg Leu Pro Gln Pro Ser Asp Gln His Phe Thr
    530                 535                 540                 
Ser Ala Val His Gln Lys His Lys Asp His Phe Arg Leu Thr Ile Pro
545                 550                 555                 560 
Arg Lys Ser Lys Leu Ala Val His Arg Asn Ile Arg Asp Asp Glu Gly
                565                 570                 575     
Phe Ile Ile Arg His Phe Ala Gly Ala Val Cys Tyr Glu Thr Thr Gln
            580                 585                 590         
Phe Val Glu Lys Asn Asn Asp Ala Leu His Met Ser Leu Glu Ser Leu
        595                 600                 605             
Ile Cys Glu Ser Arg Asp Lys Phe Ile Arg Glu Leu Phe Glu Ser Ser
    610                 615                 620                 
Thr Asn Asn Asn Lys Asp Thr Lys Gln Lys Ala Gly Lys Leu Ser Phe
625                 630                 635                 640 
Ile Ser Val Gly Asn Lys Phe Lys Thr Gln Leu Asn Leu Leu Leu Asp
                645                 650                 655     
Lys Leu Arg Ser Thr Gly Ala Ser Phe Ile Arg Cys Ile Lys Pro Asn
            660                 665                 670         
Leu Lys Met Thr Ser His His Phe Glu Gly Ala Gln Ile Leu Ser Gln
        675                 680                 685             
Leu Gln Cys Ser Gly Met Val Ser Val Leu Asp Leu Met Gln Gly Gly
    690                 695                 700                 
Tyr Pro Ser Arg Ala Ser Phe His Glu Leu Tyr Asn Met Tyr Lys Lys
705                 710                 715                 720 
Tyr Met Pro Asp Lys Leu Ala Arg Leu Asp Pro Arg Leu Phe Cys Lys
                725                 730                 735     
Ala Leu Phe Lys Ala Leu Gly Leu Asn Glu Asn Asp Tyr Lys Phe Gly
            740                 745                 750         
Leu Thr Lys Val Phe Phe Arg Pro Gly Lys Phe Ala Glu Phe Asp Gln
        755                 760                 765             
Ile Met Lys Ser Asp Pro Asp His Leu Ala Glu Leu Val Lys Arg Val
    770                 775                 780                 
Asn His Trp Leu Thr Cys Ser Arg Trp Lys Lys Val Gln Trp Cys Ser
785                 790                 795                 800 
Leu Ser Val Ile Lys Leu Lys Asn Lys Ile Lys Tyr Arg Ala Glu Ala
                805                 810                 815     
Cys Ile Lys Met Gln Lys Thr Ile Arg Met Trp Leu Cys Lys Arg Arg
            820                 825                 830         
His Lys Pro Arg Ile Asp Gly Leu Val Lys Val Gly Thr Leu Lys Lys
        835                 840                 845             
Arg Leu Asp Lys Phe Asn Glu Val Val Ser Val Leu Lys Asp Gly Lys
    850                 855                 860                 
Pro Glu Met Asn Lys Gln Ile Lys Asn Leu Glu Ile Ser Ile Asp Thr
865                 870                 875                 880 
Leu Met Ala Lys Ile Lys Ser Thr Met Met Thr Gln Glu Gln Ile Gln
                885                 890                 895     
Lys Glu Tyr Asp Ala Leu Val Lys Ser Ser Glu Glu Leu Leu Ser Ala
            900                 905                 910         
Leu Gln Lys Lys Lys Gln Gln Glu Glu Glu Ala Glu Arg Leu Arg Arg
        915                 920                 925             
Ile Gln Glu Glu Met Glu Lys Glu Arg Lys Arg Arg Glu Glu Asp Glu
    930                 935                 940                 
Lys Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Met Lys Leu Glu Met
945                 950                 955                 960 
Glu Ala Lys Arg Lys Gln Glu Glu Glu Glu Arg Lys Lys Arg Glu Asp
                965                 970                 975     
Asp Glu Lys Arg Ile Gln Ala Glu Val Glu Ala Gln Leu Ala Arg Gln
            980                 985                 990         
Lys Glu Glu Glu Ser Gln Gln Gln Ala Val Leu Glu Gln Glu Arg Arg
        995                 1000                1005            
Asp Arg Glu Leu Ala Leu Arg Ile Ala Gln Ser Glu Ala Glu Leu Ile
    1010                1015                1020                
Ser Asp Glu Ala Gln Ala Asp Leu Ala Leu Arg Arg Asn Asp Gly Thr
1025                1030                1035                1040
Arg Pro Lys Met Thr Pro Glu Gln Met Ala Lys Glu Met Ser Glu Phe
                1045                1050                1055    
Leu Ser Arg Gly Pro Ala Val Leu Ala Thr Lys Ala Ala Ala Gly Thr
            1060                1065                1070        
Lys Lys Tyr Asp Leu Ser Lys Trp Lys Tyr Ala Glu Leu Arg Asp Thr
        1075                1080                1085            
Ile Asn Thr Ser Cys Asp Ile Glu Leu Leu Ala Ala Cys Arg Glu Glu
    1090                1095                1100                
Phe His Arg Arg Leu Lys Val Tyr His Ala Trp Lys Ser Lys Asn Lys
1105                1110                1115                1120
Lys Arg Asn Thr Glu Thr Glu Gln Arg Ala Pro Lys Ser Val Thr Asp
                1125                1130                1135    
Tyr Asp Phe Ala Pro Phe Leu Asn Asn Ser Pro Gln Gln Asn Pro Ala
            1140                1145                1150        
Ala Gln Ile Pro Ala Arg Gln Arg Glu Ile Glu Met Asn Arg Gln Gln
        1155                1160                1165            
Arg Phe Phe Arg Ile Pro Phe Ile Arg Pro Ala Asp Gln Tyr Lys Asp
    1170                1175                1180                
Pro Gln Ser Lys Lys Lys Gly Trp Trp Tyr Ala His Phe Asp Gly Pro
1185                1190                1195                1200
Trp Ile Ala Arg Gln Met Glu Leu His Pro Asp Lys Pro Pro Ile Leu
                1205                1210                1215    
Leu Val Ala Gly Lys Asp Asp Met Glu Met Cys Glu Leu Asn Leu Glu
            1220                1225                1230        
Glu Thr Gly Leu Thr Arg Lys Arg Gly Ala Glu Ile Leu Pro Arg Gln
        1235                1240                1245            
Phe Glu Glu Ile Trp Glu Arg Cys Gly Gly Ile Gln Tyr Leu Gln Asn
    1250                1255                1260                
Ala Ile Glu Ser Arg Gln Ala Arg Pro Thr Tyr Ala Thr Ala Met Leu
1265                1270                1275                1280
Gln Ser Leu Leu Lys
                1285


<210> 8548
<211> 1179
<212> PRT
<213> Homo sapiens

<400> 8548
Gly Asn Leu Ala Val Thr Ser Lys Glu Asp Leu Ile Leu Tyr Phe Trp
 1               5                  10                  15      
Thr Ala Tyr Ile Tyr Asn Lys Ala Ile Lys Met Ser Gly Ala Ser Val
            20                  25                  30          
Lys Val Ala Val Arg Val Arg Pro Phe Asn Ser Arg Glu Thr Ser Lys
        35                  40                  45              
Glu Ser Lys Cys Ile Ile Gln Met Gln Gly Asn Ser Thr Ser Ile Ile
    50                  55                  60                  
Asn Pro Lys Asn Pro Lys Glu Ala Pro Lys Ser Phe Ser Phe Asp Tyr
65                  70                  75                  80  
Ser Tyr Trp Ser His Thr Ser Pro Glu Asp Pro Cys Phe Ala Ser Gln
                85                  90                  95      
Asn Arg Val Tyr Asn Asp Ile Gly Lys Glu Met Leu Leu His Ala Phe
            100                 105                 110         
Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ala Gly
        115                 120                 125             
Lys Ser Tyr Thr Met Met Gly Lys Gln Glu Glu Ser Gln Ala Gly Ile
    130                 135                 140                 
Ile Pro Gln Leu Cys Glu Glu Leu Phe Glu Lys Ile Asn Asp Asn Cys
145                 150                 155                 160 
Asn Glu Glu Met Ser Tyr Ser Val Glu Val Ser Tyr Met Glu Ile Tyr
                165                 170                 175     
Cys Glu Arg Val Arg Asp Leu Leu Asn Pro Lys Asn Lys Gly Asn Leu
            180                 185                 190         
Arg Val Arg Glu His Pro Leu Leu Gly Pro Tyr Val Glu Asp Leu Ser
        195                 200                 205             
Lys Leu Ala Val Thr Ser Tyr Thr Asp Ile Ala Asp Leu Met Asp Ala
    210                 215                 220                 
Gly Asn Lys Ala Arg Thr Val Ala Ala Thr Asn Met Asn Glu Thr Ser
225                 230                 235                 240 
Ser Arg Ser His Ala Val Phe Thr Ile Val Phe Thr Gln Lys Lys His
                245                 250                 255     
Asp Asn Glu Thr Asn Leu Ser Thr Glu Lys Val Ser Lys Ile Ser Leu
            260                 265                 270         
Val Asp Leu Ala Gly Ser Glu Arg Ala Asp Ser Thr Gly Ala Lys Gly
        275                 280                 285             
Thr Arg Leu Lys Glu Gly Ala Asn Ile Asn Lys Ser Leu Thr Thr Leu
    290                 295                 300                 
Gly Lys Val Ile Ser Ala Leu Ala Glu Val Ser Lys Lys Lys Lys Lys
305                 310                 315                 320 
Thr Asp Phe Ile Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Arg
                325                 330                 335     
Glu Asn Leu Gly Gly Asn Ser Arg Thr Ala Met Val Ala Ala Leu Ser
            340                 345                 350         
Pro Ala Asp Ile Asn Tyr Asp Glu Thr Leu Ser Thr Leu Arg Tyr Ala
        355                 360                 365             
Asp Arg Ala Lys Gln Ile Lys Cys Asn Ala Val Ile Asn Glu Asp Pro
    370                 375                 380                 
Asn Ala Lys Leu Val Arg Glu Leu Lys Glu Glu Val Thr Arg Leu Lys
385                 390                 395                 400 
Asp Leu Leu Arg Ala Gln Gly Leu Gly Asp Ile Ile Asp Thr Ser Met
                405                 410                 415     
Gly Ser Leu Thr Ser Ser Pro Ser Ser Cys Ser Leu Ser Ser Gln Val
            420                 425                 430         
Gly Leu Thr Ser Val Thr Ser Ile Gln Glu Arg Ile Met Ser Thr Pro
        435                 440                 445             
Gly Gly Glu Glu Ala Ile Glu Arg Leu Lys Glu Ser Glu Lys Ile Ile
    450                 455                 460                 
Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys Leu Arg Lys Thr Glu Ala
465                 470                 475                 480 
Ile Arg Met Glu Arg Glu Ala Leu Leu Ala Glu Met Gly Val Ala Ile
                485                 490                 495     
Arg Glu Asp Gly Gly Thr Leu Gly Val Phe Ser Pro Lys Lys Thr Pro
            500                 505                 510         
His Leu Val Asn Leu Asn Glu Asp Pro Leu Met Ser Glu Cys Leu Leu
        515                 520                 525             
Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val Gly Gln Ala Asp Ala Glu
    530                 535                 540                 
Arg Arg Gln Asp Ile Val Leu Ser Gly Ala His Ile Lys Glu Glu His
545                 550                 555                 560 
Cys Ile Phe Arg Ser Glu Arg Ser Asn Ser Gly Glu Val Ile Val Thr
                565                 570                 575     
Leu Glu Pro Cys Glu Arg Ser Glu Thr Tyr Val Asn Gly Lys Arg Val
            580                 585                 590         
Ser Gln Pro Val Gln Leu Arg Ser Gly Asn Arg Ile Ile Met Gly Lys
        595                 600                 605             
Asn His Val Phe Arg Phe Asn His Pro Glu Gln Ala Arg Ala Glu Arg
    610                 615                 620                 
Glu Lys Thr Pro Ser Ala Glu Thr Pro Ser Glu Pro Val Asp Trp Thr
625                 630                 635                 640 
Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln Gly Ile Asp Met Lys Gln
                645                 650                 655     
Glu Met Glu Lys Arg Leu Gln Glu Met Glu Ile Leu Tyr Lys Lys Glu
            660                 665                 670         
Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln Gln Arg Leu Asp Ala Asp
        675                 680                 685             
Ser Asp Ser Gly Asp Asp Ser Asp Lys Arg Ser Cys Glu Glu Ser Trp
    690                 695                 700                 
Lys Leu Ile Thr Ser Leu Arg Glu Lys Leu Pro Pro Ser Lys Leu Gln
705                 710                 715                 720 
Thr Ile Val Lys Lys Cys Gly Leu Pro Ser Ser Gly Lys Lys Arg Glu
                725                 730                 735     
Pro Ile Lys Met Tyr Gln Ile Pro Gln Arg Arg Arg Leu Ser Lys Asp
            740                 745                 750         
Ser Lys Trp Val Thr Ile Ser Asp Leu Lys Ile Gln Ala Val Lys Glu
        755                 760                 765             
Ile Cys Tyr Glu Val Ala Leu Asn Asp Phe Arg His Ser Arg Gln Glu
    770                 775                 780                 
Ile Glu Ala Leu Ala Ile Val Lys Met Lys Glu Leu Cys Ala Met Tyr
785                 790                 795                 800 
Gly Lys Lys Asp Pro Asn Glu Arg Asp Ser Trp Arg Ala Val Ala Arg
                805                 810                 815     
Asp Val Trp Asp Thr Val Gly Val Gly Asp Glu Lys Ile Glu Asp Val
            820                 825                 830         
Met Ala Thr Gly Lys Gly Ser Thr Asp Val Asp Asp Leu Lys Val His
        835                 840                 845             
Ile Asp Lys Leu Glu Asp Ile Leu Gln Glu Val Lys Lys Gln Asn Asn
    850                 855                 860                 
Met Lys Asp Glu Glu Ile Lys Val Leu Arg Asn Lys Met Leu Lys Met
865                 870                 875                 880 
Glu Lys Val Leu Pro Leu Ile Gly Ser Gln Glu Gln Lys Ser Pro Gly
                885                 890                 895     
Ser His Lys Ala Lys Glu Pro Val Gly Ala Gly Val Ser Ser Thr Ser
            900                 905                 910         
Glu Asn Asn Val Ser Lys Gly Asp Asn Gly Glu Leu Ala Lys Glu Glu
        915                 920                 925             
Arg Val Ser Gln Leu Met Asn Gly Asp Pro Ala Phe Arg Arg Gly Arg
    930                 935                 940                 
Leu Arg Trp Met Arg Gln Glu Gln Ile Arg Phe Lys Asn Leu Gln Gln
945                 950                 955                 960 
Gln Glu Ile Thr Lys Gln Leu Arg Arg Gln Asn Val Pro His Arg Phe
                965                 970                 975     
Ile Pro Pro Glu Asn Arg Lys Pro Arg Phe Pro Phe Lys Ser Asn Pro
            980                 985                 990         
Lys His Arg Asn Ser Trp Ser Pro Gly Thr His Ile Ile Ile Thr Glu
        995                 1000                1005            
Asp Glu Val Ile Glu Leu Arg Ile Pro Lys Asp Asp Glu Ala Arg Lys
    1010                1015                1020                
Gly Asn Lys Glu Glu Ser Gln Glu Lys Gly Gly Lys Gly Ala Phe Lys
1025                1030                1035                1040
Asp Pro Gln Phe Pro Trp Gly Ser Gln Gly Met Arg Ser Gln Asp His
                1045                1050                1055    
Ile Gln Val Ser Lys Gln His Ile Asn Asn Gln Gln Gln Pro Pro Gln
            1060                1065                1070        
Leu Arg Trp Arg Ser Asn Ser Leu Asn Asn Gly Gln Pro Lys Ser Thr
        1075                1080                1085            
Arg Cys Gln Ala Ser Ala Ser Ala Glu Ser Leu Asn Ser His Ser Gly
    1090                1095                1100                
His Pro Thr Ala Asp Val Gln Thr Phe Gln Ala Lys Arg His Ile His
1105                1110                1115                1120
Gln His Arg Gln Ser Tyr Cys Asn Tyr Asn Thr Gly Gly Gln Leu Glu
                1125                1130                1135    
Gly Asn Ala Ala Thr Ser Tyr Gln Lys Gln Thr Asp Lys Pro Ser His
            1140                1145                1150        
Cys Ser Gln Phe Val Thr Pro Pro Arg Met Arg Arg Gln Phe Ser Ala
        1155                1160                1165            
Pro Asn Leu Lys Ala Gly Arg Glu Thr Thr Val
    1170                1175                


<210> 8549
<211> 1153
<212> PRT
<213> Homo sapiens

<400> 8549
Met Ser Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn
 1               5                  10                  15      
Ser Arg Glu Thr Ser Lys Glu Ser Lys Cys Ile Ile Gln Met Gln Gly
            20                  25                  30          
Asn Ser Thr Ser Ile Ile Asn Pro Lys Asn Pro Lys Glu Ala Pro Lys
        35                  40                  45              
Ser Phe Ser Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp
    50                  55                  60                  
Pro Cys Phe Ala Ser Gln Asn Arg Val Tyr Asn Asp Ile Gly Lys Glu
65                  70                  75                  80  
Met Leu Leu His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr
                85                  90                  95      
Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu
            100                 105                 110         
Glu Ser Gln Ala Gly Ile Ile Pro Gln Leu Cys Glu Glu Leu Phe Glu
        115                 120                 125             
Thr Asn His Asp Asn Cys Asn Glu Glu Met Ser Tyr Ser Val Glu Val
    130                 135                 140                 
Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro
145                 150                 155                 160 
Lys Asn Lys Gly Asn Leu Arg Val Arg Asp His Pro Leu Arg Gly Pro
                165                 170                 175     
Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Thr Asp Ile
            180                 185                 190         
Ala Asp Leu Met Asp Ala Gly Asn Lys Ala Arg Thr Val Ala Ala Thr
        195                 200                 205             
Asn Met Asn Glu Thr Ser Ser Arg Ser His Val Val Tyr Thr Ile Val
    210                 215                 220                 
Phe Thr Gln Lys Lys His Asp Asn Glu Thr Ile Leu Ala Thr Val Lys
225                 230                 235                 240 
Val Ser Lys Thr Ser Leu Val Asp Leu Ala Gly Ser Asp Arg Ala Ala
                245                 250                 255     
Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Ile Ile Asn
            260                 265                 270         
Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Val
        275                 280                 285             
Ser Lys Lys Lys Lys Lys Thr Asp Phe Ile Pro Tyr Arg Asp Ser Val
    290                 295                 300                 
Leu Thr Trp Leu Leu Arg Glu Asn Leu Gly Gly Asn Ser Arg Thr Ala
305                 310                 315                 320 
Met Val Ala Ala Leu Ser Pro Ala Asp Ile Asn Tyr Asp Glu Thr Leu
                325                 330                 335     
Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Gln Ile Lys Cys Asn Ala
            340                 345                 350         
Val Ile Asn Glu Asp Pro Asn Ala Lys Leu Val Arg Glu Leu Lys Glu
        355                 360                 365             
Glu Val Thr Arg Leu Lys Asp Leu Leu Arg Ala Gln Gly Leu Gly Asp
    370                 375                 380                 
Ile Ile Asp Thr Ser Met Gly Ser Leu Thr Ser Ser Pro Ser Ser Cys
385                 390                 395                 400 
Ser Leu Ser Ser Gln Val Gly Leu Thr Ser Val Thr Ser Ile Gln Glu
                405                 410                 415     
Arg Ile Met Ser Thr Pro Gly Gly Glu Glu Ala Ile Glu Arg Leu Lys
            420                 425                 430         
Glu Ser Glu Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys
        435                 440                 445             
Leu Arg Lys Thr Glu Ala Ile Arg Met Glu Arg Glu Ala Leu Leu Ala
    450                 455                 460                 
Glu Met Gly Val Ala Ile Arg Glu Asp Gly Gly Thr Leu Gly Val Phe
465                 470                 475                 480 
Ser Pro Lys Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu
                485                 490                 495     
Met Ser Glu Cys Leu Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val
            500                 505                 510         
Gly Gln Ala Asp Ala Glu Arg Arg Gln Asp Ile Val Leu Ser Gly Ala
        515                 520                 525             
His Ile Lys Glu Glu His Cys Ile Phe Arg Ser Glu Arg Ser Asn Ser
    530                 535                 540                 
Gly Glu Val Ile Val Thr Leu Glu Pro Cys Glu Arg Ser Glu Thr Tyr
545                 550                 555                 560 
Val Asn Gly Lys Arg Val Ser Gln Pro Val Gln Leu Arg Ser Gly Asn
                565                 570                 575     
Arg Ile Ile Met Gly Lys Asn His Val Phe Arg Phe Asn His Pro Glu
            580                 585                 590         
Gln Ala Arg Ala Glu Arg Glu Lys Thr Pro Ser Ala Glu Thr Pro Ser
        595                 600                 605             
Glu Pro Val Asp Trp Thr Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln
    610                 615                 620                 
Gly Ile Asp Met Lys Gln Glu Met Glu Lys Arg Leu Gln Glu Met Glu
625                 630                 635                 640 
Ile Leu Tyr Lys Lys Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln
                645                 650                 655     
Gln Arg Leu Asp Ala Asp Ser Asp Ser Gly Asp Asp Ser Asp Lys Arg
            660                 665                 670         
Ser Cys Glu Glu Ser Trp Lys Leu Ile Thr Ser Leu Arg Glu Lys Leu
        675                 680                 685             
Pro Pro Ser Lys Leu Gln Thr Ile Val Lys Lys Cys Gly Leu Pro Ser
    690                 695                 700                 
Ser Gly Lys Lys Arg Glu Pro Ile Lys Met Tyr Gln Ile Pro Gln Arg
705                 710                 715                 720 
Arg Arg Leu Ser Lys Asp Ser Lys Trp Val Thr Ile Ser Asp Leu Lys
                725                 730                 735     
Ile Gln Ala Val Lys Glu Ile Cys Tyr Glu Val Ala Leu Asn Asp Phe
            740                 745                 750         
Arg His Ser Arg Gln Glu Ile Glu Ala Leu Ala Ile Val Lys Met Lys
        755                 760                 765             
Glu Leu Cys Ala Met Tyr Gly Lys Lys Asp Pro Asn Glu Arg Asp Ser
    770                 775                 780                 
Trp Arg Ala Val Ala Arg Asp Val Trp Asp Thr Val Gly Val Gly Asp
785                 790                 795                 800 
Glu Lys Ile Glu Asp Val Met Ala Thr Gly Lys Gly Ser Thr Asp Val
                805                 810                 815     
Asp Asp Leu Lys Val His Ile Asp Lys Leu Glu Asp Ile Leu Gln Glu
            820                 825                 830         
Val Lys Lys Gln Asn Asn Met Lys Asp Glu Glu Ile Lys Val Leu Arg
        835                 840                 845             
Asn Lys Met Leu Lys Met Glu Lys Val Leu Pro Leu Ile Gly Ser Gln
    850                 855                 860                 
Glu Gln Lys Ser Pro Gly Ser His Lys Ala Lys Glu Pro Val Gly Ala
865                 870                 875                 880 
Gly Val Ser Ser Thr Ser Glu Asn Asn Val Ser Lys Gly Asp Asn Gly
                885                 890                 895     
Glu Leu Ala Lys Glu Glu Arg Val Ser Gln Leu Met Asn Gly Asp Pro
            900                 905                 910         
Ala Phe Arg Arg Gly Arg Leu Arg Trp Met Arg Gln Glu Gln Ile Arg
        915                 920                 925             
Phe Lys Asn Leu Gln Gln Gln Glu Ile Thr Lys Gln Leu Arg Arg Gln
    930                 935                 940                 
Asn Val Pro His Arg Phe Ile Pro Pro Glu Asn Arg Lys Pro Arg Phe
945                 950                 955                 960 
Pro Phe Lys Ser Asn Pro Lys His Arg Asn Ser Trp Ser Pro Gly Thr
                965                 970                 975     
His Ile Ile Ile Thr Glu Asp Glu Val Ile Glu Leu Arg Ile Pro Lys
            980                 985                 990         
Asp Asp Glu Ala Arg Lys Gly Asn Lys Glu Glu Ser Gln Glu Lys Gly
        995                 1000                1005            
Gly Lys Gly Ala Phe Lys Asp Pro Gln Phe Pro Trp Gly Ser Gln Gly
    1010                1015                1020                
Met Arg Ser Gln Asp His Ile Gln Val Ser Lys Gln His Ile Asn Asn
1025                1030                1035                1040
Gln Gln Gln Pro Pro Gln Leu Arg Trp Arg Ser Asn Ser Leu Asn Asn
                1045                1050                1055    
Gly Gln Pro Lys Ser Thr Arg Cys Gln Ala Ser Ala Ser Ala Glu Ser
            1060                1065                1070        
Leu Asn Ser His Ser Gly His Pro Thr Ala Asp Val Gln Thr Phe Gln
        1075                1080                1085            
Ala Lys Arg His Ile His Gln His Arg Gln Ser Tyr Cys Asn Tyr Asn
    1090                1095                1100                
Thr Gly Gly Gln Leu Glu Gly Asn Ala Ala Thr Ser Tyr Gln Lys Gln
1105                1110                1115                1120
Thr Asp Lys Pro Ser His Cys Ser Gln Phe Val Thr Pro Pro Arg Met
                1125                1130                1135    
Arg Arg Gln Phe Ser Ala Pro Asn Leu Lys Ala Gly Arg Glu Thr Thr
            1140                1145                1150        
Val
    


<210> 8550
<211> 1520
<212> PRT
<213> Homo sapiens

<400> 8550
Glu Val Ile Phe Met Asp Asn Gln Gln Asp Lys Ala Ile Val Ala Ser
 1               5                  10                  15      
Ala Asn Gly Glu Asn Thr Leu Ile Asn Gly Val Lys Glu Asn Asp Ser
            20                  25                  30          
Glu Asp Gln Asp Val Ala Met Lys Ser Phe Ala Ala Leu Glu Ala Ala
        35                  40                  45              
Ala Pro Ile Gln Pro Thr Pro Val Ala Gln Lys Glu Thr Leu Met Tyr
    50                  55                  60                  
Pro Arg Gly Leu Leu Pro Leu Pro Ser Lys Lys Pro Cys Met Gln Ser
65                  70                  75                  80  
Pro Pro Ser Pro Leu Gly Leu Ile Glu Ala Pro Glu His Ala Ala Asn
                85                  90                  95      
Ser Ala Ser Val Asn Ala Ile Ser Leu Thr Ser Gly Ile Ala Lys Gly
            100                 105                 110         
Leu Asn Thr Trp Ser Leu Pro Asn Glu Cys Glu Lys Ala Pro Phe Ala
        115                 120                 125             
Ile Met Glu Pro Ala Gly Met Ser Ala Leu Asn Gly Asp Cys Leu Met
    130                 135                 140                 
Gln Pro Ser Arg Thr Cys Leu Gly Cys Phe Met Glu Ser Lys Asp Ala
145                 150                 155                 160 
Val Asp Pro Glu Pro Gly Ile Ser Leu Lys Val Gly Asp Leu Asn Arg
                165                 170                 175     
Asp Tyr Glu Thr Cys Ala Val Ser Asp Ile Gly Ile Gln Cys Ile Asn
            180                 185                 190         
Ala Gly Glu Asn Met Lys Tyr Gly Glu Gln Leu Leu Ser Asp Gln Leu
        195                 200                 205             
Leu Gly Phe Pro Leu His Lys Ser Arg Ala Gly Asp Arg Arg Glu Thr
    210                 215                 220                 
Glu Lys Pro Asp Ile Asp Leu Glu Asp Pro Ala Gln Lys Ser Tyr Tyr
225                 230                 235                 240 
Glu Ala Leu Leu Leu Asp Lys Cys Asn Thr Glu Glu Ala Leu Leu Ala
                245                 250                 255     
Asn Ser Asn Gln Asp Trp Gly Tyr Phe Glu Thr Phe Ile Ser Glu Ser
            260                 265                 270         
Lys Ile Glu Leu Leu Asp Leu Cys Ser Lys Asn Glu Leu Ser Val Asn
        275                 280                 285             
Leu Phe Ser Glu Glu Asp Val Asp Asn Tyr Met Phe Asp Asp Asp Glu
    290                 295                 300                 
Ser Thr Leu Gly Ser Asp Val Cys Ser Leu Lys Ile Arg Tyr Glu Ser
305                 310                 315                 320 
Phe Gln Asp Asn Val Arg Asp Lys Thr Thr Leu Leu Met Gln Glu Asp
                325                 330                 335     
Ala Gln Phe Asn Phe Phe Pro Ser Val Phe Thr Thr Cys Pro Lys Arg
            340                 345                 350         
Glu Ser Lys Ser Gly Ala Leu Lys Gln Ser Ser Asp Phe Ser Gln Phe
        355                 360                 365             
Lys Val Pro Asp Val Ser Ile Ile Trp Gly Glu Glu Asp Lys Asn Leu
    370                 375                 380                 
Asp Lys Lys Lys Gly Lys Glu Glu Gly Gln Glu Asp Lys Gly Val Glu
385                 390                 395                 400 
Lys Lys Asp Gly Lys Asp Asn Gly Glu Lys Pro Ala Leu Asn Lys Pro
                405                 410                 415     
Cys Ser Gly Thr Glu Val Glu Gln Leu Lys Asn Pro Lys Gln Gly His
            420                 425                 430         
Leu Ala Asn Ser Leu Glu Thr Ser Gly Ser Phe Ser Asp Asp Ser Ser
        435                 440                 445             
Phe Ile Glu Ile Ser Tyr Asp Ala Met Gly Glu Ile Lys Asp Cys Ser
    450                 455                 460                 
Arg Tyr Met Ala Arg Asp Thr Asn Ser Gly Ser Ser Ser Ser Gln Gln
465                 470                 475                 480 
Asn Tyr Gly Leu Arg Ala Lys Arg Lys Val Arg Tyr Ser Glu Asp Tyr
                485                 490                 495     
Leu Tyr Asp Val Asp Ser Leu Glu Gly Glu Lys Val Asn Glu Arg Lys
            500                 505                 510         
Glu Trp Leu Pro Val Gly Ser Lys Glu Glu Asp Asp Asp Glu Trp Cys
        515                 520                 525             
Pro Lys Lys Arg Arg Lys Val Thr Arg Lys Glu Pro Pro Val Ile Ile
    530                 535                 540                 
Lys Tyr Ile Ile Ile Asn Arg Phe Lys Gly Glu Lys Asn Met Leu Val
545                 550                 555                 560 
Lys Leu Gly Lys Val Asp Ala Ser Glu Thr Thr Val Asn Leu Ser Glu
                565                 570                 575     
Asn Gln Leu Asn Lys Tyr Ala Lys Leu Ala Pro Leu Lys Gly Phe Trp
            580                 585                 590         
Gln Lys Lys Lys Lys Gln Arg Asn Thr Asn Thr Asp Ser Ile Lys Thr
        595                 600                 605             
Pro Phe Ser Gln Lys Gln Ser Phe Glu Pro Gly Ser Phe Glu Val Ser
    610                 615                 620                 
Phe Leu Pro Pro Ala Arg Lys Arg Lys Ser Lys Leu Gly Asn Arg His
625                 630                 635                 640 
Arg Ile Gln Arg Ile Pro Ser Ile Glu Ile Ser Ala Ser Ser Lys Gln
                645                 650                 655     
Ile Ser Leu Cys Asn Asp Gln Arg His Ala Ser Asn His Lys Glu Asp
            660                 665                 670         
Gly Gly Leu Lys Gly Thr Leu Lys Ser Ala Pro Leu Gly Ala Pro Ser
        675                 680                 685             
Cys Ala Asn Gly Ser His Leu Asn Asp Ile Thr Gly Pro Asp Ser Val
    690                 695                 700                 
Lys Val Lys Ala Gln Asp Thr Glu Phe Lys Gly Pro Glu Arg Lys Val
705                 710                 715                 720 
Leu Asn Lys Ile Lys Phe Lys Ser Glu Ala Arg Leu Lys Ser Lys Lys
                725                 730                 735     
Val Lys Ala Ala Gly Gln Glu Ser Lys Pro Ile Val Gln Met Ser Pro
            740                 745                 750         
Leu Leu Glu Asn Gln Ser Ser Lys Ala Asn Leu Lys Asn Glu Val Ile
        755                 760                 765             
Pro Gly Thr Ser Asn Ser Ser Arg Leu Ser Glu Phe His Glu Ala Lys
    770                 775                 780                 
Ala Ala Lys Ser Ser Thr Phe Leu Pro Thr Thr Cys Ser Ser Glu Met
785                 790                 795                 800 
Pro Leu Ser Ser Ala Asn Val Thr Thr Asn Ile Pro Val Ile Pro Gly
                805                 810                 815     
Gly Tyr Leu Gln Thr Leu Leu Asp Ala Ser Asp Leu Ser Asn Asn Thr
            820                 825                 830         
Ser Ile Ser Tyr Phe Ser His His Ser Pro Glu Gln Asn Glu Gly Ser
        835                 840                 845             
Leu Thr Gln Thr Glu Lys Ser Phe Val Pro Leu Gln Pro Thr Gln Asp
    850                 855                 860                 
Cys Val Leu Thr Ser Ser Ser Asp Ser Glu Leu Gln Gln Ser Ser His
865                 870                 875                 880 
Asn Phe Lys Met Glu Ser Ser Asn Tyr Arg Asn Val Trp Pro Asn Lys
                885                 890                 895     
Ala Thr Ser Gly Thr Gln Glu Phe Met Ala Glu Val Ser Arg Glu Ile
            900                 905                 910         
Ala Pro Thr Gln Ser Ser Glu Phe Gly Ala Ser Gln Val Val Ser Met
        915                 920                 925             
Glu Asn Asn Leu Thr Pro Thr Thr Tyr Asn Pro Ile Cys Leu Asn Ser
    930                 935                 940                 
Gly Gly Ser Asn Cys Asn Lys Val Leu Tyr Asp Ser Met Gln Asp Thr
945                 950                 955                 960 
Gln Leu Pro Ser Asp Asp Ser Tyr Gln Leu Cys His Phe Asn Asn Gly
                965                 970                 975     
Glu Ile Cys Phe Pro Phe Gln Gln Gly Pro Val Asn Met Asp Asp Gly
            980                 985                 990         
Arg Leu Phe Ser Phe Asp Ser Met Ala Pro Leu Ser Val Ser Ser Ser
        995                 1000                1005            
Asn Tyr Cys Ser Leu Ser Leu Lys Ser Cys Glu Lys Asp Gly Asp Asp
    1010                1015                1020                
Asp Ile Thr Asp Asp Phe Leu Ala His Cys Ser Pro Lys Leu Val Ile
1025                1030                1035                1040
Gln Gln Ser Ile Asp Glu Ile Ala Pro Leu Lys Glu Ser Thr Asp Leu
                1045                1050                1055    
Leu Asp Ile Ser Asn Phe Thr Pro Asp Lys Phe Arg His Ser Ser Leu
            1060                1065                1070        
Ser Glu Met Ser Pro Pro Asp Thr Pro Ser Leu Ser Pro Gln Ile Thr
        1075                1080                1085            
Arg Cys Glu Ser Met Lys Thr Leu Gly Thr Leu Lys Gly Phe Gln Glu
    1090                1095                1100                
Gly Val Pro Gly Pro Leu Asp Ser Val Glu Lys Ile Lys Trp Asp Cys
1105                1110                1115                1120
Ser Thr Leu Ser Arg Gln Val Gln Met Glu Asp Gly Phe Thr Leu Asn
                1125                1130                1135    
Asn His Gln Phe Gln Phe His Met Phe Asn Asp Glu Asp Ser Val Ser
            1140                1145                1150        
Leu Leu Gln Lys Asn Pro Cys Leu Ser Thr Phe Asn Asp Pro Ser Gly
        1155                1160                1165            
Gln Ile Ser Thr Asn Asn Lys Val Ser Lys Ser Arg Lys Lys Ser Ser
    1170                1175                1180                
Pro Ser Lys Ser Gly Ala Met Asn Gln Ser Ser Ser Gln Lys Asn Thr
1185                1190                1195                1200
Arg Lys Lys Ser Leu Lys Gly Asn Asn Lys Gly Ile Glu Lys Pro Pro
                1205                1210                1215    
Gly Lys Asn Ser Arg Gln Val Pro Lys Ser Thr Lys Lys Gly Lys Tyr
            1220                1225                1230        
Met Ala Ala Ile Asn Gly Glu Lys Met Gln Ile Gly Ile Gly Arg Gly
        1235                1240                1245            
Gly Ser Gln Thr Asn Thr Ile Ser Ser Thr Gly Lys Thr Leu Ala Glu
    1250                1255                1260                
Cys Ile Gln His Gly Gly Pro Met Ala Ser Met Lys Met Pro Ser Gln
1265                1270                1275                1280
Lys Gly Leu Ser Gly Asp Trp Ala Leu Gly Lys Glu Ser Ser Pro Gly
                1285                1290                1295    
Trp Ser Asp Met Ser Met Gly Thr Asn Thr Asn Ser Leu Leu Asp Asp
            1300                1305                1310        
Asp Gln Arg Glu Phe Gln Glu Pro Ser Tyr Ile Leu Ser Asn Ile Ala
        1315                1320                1325            
Ser Gly Met Ala Asp Val Gln Arg Phe Met Met Ala Ser Ile Glu Pro
    1330                1335                1340                
Leu Trp Glu Pro Met Glu His His Gly Asp Pro Asn Ile Phe Tyr Ser
1345                1350                1355                1360
Pro Glu Ser Asn Ser Leu Lys Leu Lys Thr Leu Lys Ile Leu Ala Gly
                1365                1370                1375    
Thr Pro Gln Glu Ser Lys Lys Lys Ile Asn Ser Gly Ser Gln Gly Ala
            1380                1385                1390        
Thr Lys Asn His Arg Ser Ile Lys Gly Val Ser Lys Ser Asn Gly Lys
        1395                1400                1405            
Thr Ala Ile Gly Asp Pro Gly Arg Ala Asn Met Pro Gly Tyr Asn Glu
    1410                1415                1420                
Asp Ser Arg Ser Thr Phe Phe Asp Lys Lys Tyr Ser Asn Met Ser Thr
1425                1430                1435                1440
Leu Gly Asn Asn Gly Pro Thr His Lys Lys Leu Tyr Arg His Lys Ser
                1445                1450                1455    
Ser Ser Lys Ala Leu Arg Asp Glu Lys Cys Lys Gly Lys His Met Glu
            1460                1465                1470        
Arg Glu Gln Val His Lys Asp Glu Ser Gly Thr Ala Ser Phe Glu Lys
        1475                1480                1485            
Leu Arg Asp Ser Asp Tyr Asn Leu Leu Lys Ala Glu Thr Thr Phe Trp
    1490                1495                1500                
Val Leu Pro Val Phe Glu Glu Glu Thr Arg Ile Phe Gln Lys Asp Ile
1505                1510                1515                1520


<210> 8551
<211> 101
<212> PRT
<213> Homo sapiens

<400> 8551
Met Pro Arg Lys Ile Thr Glu Val Leu Val Arg Lys Val Pro Asp Asn
 1               5                  10                  15      
Gln Gln Phe Leu Asp Leu Arg Val Ala Val Leu Gly Asn Val Asp Ser
            20                  25                  30          
Gly Lys Ser Thr Leu Leu Gly Val Leu Thr Gln Gly Glu Leu Asp Asn
        35                  40                  45              
Gly Arg Gly Arg Ala Arg Leu Asn Leu Phe Arg His Leu His Glu Ile
    50                  55                  60                  
Gln Ser Gly Arg Thr Ser Ser Ile Ser Phe Glu Ile Leu Gly Phe Asn
65                  70                  75                  80  
Ser Lys Gly Glu Val His Gly Ile Asn Gly Thr Gln Trp Gly Gln Thr
                85                  90                  95      
Leu Arg Met Gly Trp
            100     


<210> 8552
<211> 285
<212> PRT
<213> Homo sapiens

<400> 8552
Met Gly Thr Pro Gly Glu Gly Leu Gly Arg Cys Ser His Ala Leu Ile
 1               5                  10                  15      
Arg Gly Val Pro Glu Ser Leu Ala Ser Gly Glu Gly Ala Gly Ala Gly
            20                  25                  30          
Leu Pro Ala Leu Asp Leu Ala Lys Ala Gln Arg Glu His Gly Val Leu
        35                  40                  45              
Gly Gly Lys Leu Arg Gln Arg Leu Gly Leu Gln Leu Leu Glu Leu Pro
    50                  55                  60                  
Pro Glu Glu Ser Leu Pro Leu Gly Pro Leu Leu Gly Asp Thr Ala Val
65                  70                  75                  80  
Ile Gln Gly Asp Thr Ala Leu Ile Thr Arg Pro Trp Ser Pro Ala Arg
                85                  90                  95      
Arg Pro Glu Val Asp Gly Val Arg Lys Ala Leu Gln Asp Leu Gly Leu
            100                 105                 110         
Arg Ile Val Glu Ile Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp
        115                 120                 125             
Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Trp Thr
    130                 135                 140                 
Asn His Arg Gly Ala Glu Ile Val Ala Asp Thr Phe Arg Asp Phe Ala
145                 150                 155                 160 
Val Ser Thr Val Pro Val Ser Gly Pro Ser His Leu Arg Gly Leu Cys
                165                 170                 175     
Gly Met Gly Gly Pro Arg Thr Val Val Ala Gly Ser Ser Asp Ala Ala
            180                 185                 190         
Gln Lys Ala Val Arg Ala Met Ala Val Leu Thr Asp His Pro Tyr Ala
        195                 200                 205             
Ser Leu Thr Leu Pro Asp Asp Ala Ala Ala Asp Cys Leu Phe Leu Arg
    210                 215                 220                 
Pro Gly Leu Pro Gly Val Pro Pro Phe Leu Leu His Arg Gly Gly Gly
225                 230                 235                 240 
Asp Leu Pro Asn Ser Gln Glu Ala Leu Gln Lys Leu Ser Asp Val Thr
                245                 250                 255     
Leu Val Pro Val Ser Cys Ser Glu Leu Glu Lys Ala Gly Ala Gly Leu
            260                 265                 270         
Ser Ser Leu Cys Leu Val Leu Ser Thr Arg Pro His Ser
        275                 280                 285 


<210> 8553
<211> 425
<212> PRT
<213> Homo sapiens

<400> 8553
Met Gly Ser Gly Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly
 1               5                  10                  15      
Cys Ser Glu Gln Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn
            20                  25                  30          
Ser Asp Gln Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys
        35                  40                  45              
Thr Ala Lys Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe
    50                  55                  60                  
Ile Phe Ser Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val
65                  70                  75                  80  
Phe Leu Ser Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys
                85                  90                  95      
Gln Ser Leu Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val
            100                 105                 110         
Ala Leu Phe Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu
        115                 120                 125             
His Val Glu Gly Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala
    130                 135                 140                 
Phe Phe Ile His Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe
145                 150                 155                 160 
Thr Val Arg Asp Val Tyr Ile His Tyr Gly Gln Thr Cys Lys Leu Val
                165                 170                 175     
Cys Ser Val Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Met Lys Val
            180                 185                 190         
Asp Lys His Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu
        195                 200                 205             
His Lys Cys Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys
    210                 215                 220                 
Leu Ser Gln Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys
225                 230                 235                 240 
Glu Pro Asn Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile
                245                 250                 255     
Ser Thr Asp Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val
            260                 265                 270         
Leu Ala Pro Val Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn
        275                 280                 285             
Gly Gly Gly Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr
    290                 295                 300                 
Pro Asn Leu Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr
305                 310                 315                 320 
Arg Cys Gly Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe
                325                 330                 335     
Arg Glu Gly Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr
            340                 345                 350         
Leu Val Arg Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr
        355                 360                 365             
Tyr Thr Pro Glu Pro Gly Pro Arg Pro His Cys Ser Val Ala Gly Ala
    370                 375                 380                 
Ile Leu Pro Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr
385                 390                 395                 400 
Asn Ser Glu Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val
                405                 410                 415     
Thr Ser Ser Thr Ala Thr Val Val Ser
            420                 425 


<210> 8554
<211> 500
<212> PRT
<213> Homo sapiens

<400> 8554
Met Asp His Thr Glu Gly Leu Pro Ala Glu Glu Pro Pro Ala His Ala
 1               5                  10                  15      
Pro Ser Pro Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu Thr
            20                  25                  30          
Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln Thr Val
        35                  40                  45              
Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu Lys
    50                  55                  60                  
Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser Gly Trp
65                  70                  75                  80  
Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu Gln Glu
                85                  90                  95      
Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln Glu Met
            100                 105                 110         
Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys Thr Leu
        115                 120                 125             
Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Ile Phe Ser Val Lys
    130                 135                 140                 
Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser Lys Arg
145                 150                 155                 160 
Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu Lys Asn
                165                 170                 175     
Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe Asn Arg
            180                 185                 190         
Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu Gly Gly
        195                 200                 205             
Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile His Leu
    210                 215                 220                 
Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg Asp Val
225                 230                 235                 240 
Tyr Ile His Tyr Gly Gln Thr Cys Lys Leu Val Cys Ser Val Thr Gly
                245                 250                 255     
Met Ala Leu Pro Arg Leu Ile Ile Met Lys Val Asp Lys His Thr Ala
            260                 265                 270         
Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys Ala Phe
        275                 280                 285             
Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln Glu Arg
    290                 295                 300                 
Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn Lys Glu
305                 310                 315                 320 
Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp Lys Ala
                325                 330                 335     
Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro Val Thr
            340                 345                 350         
Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly Asp Val
        355                 360                 365             
Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu Arg Val
    370                 375                 380                 
Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly Glu Ser
385                 390                 395                 400 
Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly Trp Arg
                405                 410                 415     
Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg Asn Asp
            420                 425                 430         
Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro Glu Pro
        435                 440                 445             
Gly Pro Arg Pro His Cys Ser Val Ala Gly Ala Ile Leu Pro Ala Asn
    450                 455                 460                 
Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu Gly Ser
465                 470                 475                 480 
Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser Thr Ala
                485                 490                 495     
Thr Val Val Ser
            500 


<210> 8555
<211> 411
<212> PRT
<213> Homo sapiens

<400> 8555
Met Ala Trp Ile Lys Arg Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile
 1               5                  10                  15      
Gly Asn Ser Asp Gln Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn
            20                  25                  30          
Tyr Cys Thr Ala Lys Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys
        35                  40                  45              
His Phe Ile Phe Ser Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile
    50                  55                  60                  
Gly Val Phe Leu Ser Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys
65                  70                  75                  80  
Lys Lys Gln Ser Leu Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr
                85                  90                  95      
Lys Val Ala Leu Phe Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg
            100                 105                 110         
Tyr Leu His Val Glu Gly Gly Asn Phe His Ala Ser Ser Gln Gln Trp
        115                 120                 125             
Gly Ala Phe Phe Ile His Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu
    130                 135                 140                 
Glu Phe Thr Val Arg Asp Val Tyr Ile His Tyr Gly Gln Thr Cys Lys
145                 150                 155                 160 
Leu Val Cys Ser Val Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Met
                165                 170                 175     
Lys Val Asp Lys His Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser
            180                 185                 190         
Gln Leu His Lys Cys Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr
        195                 200                 205             
Leu Cys Leu Ser Gln Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys
    210                 215                 220                 
Pro Lys Glu Pro Asn Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr
225                 230                 235                 240 
Ile Ile Ser Thr Asp Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly
                245                 250                 255     
Pro Val Leu Ala Pro Val Thr Pro Val Pro Val Val Glu Ser Leu Gln
            260                 265                 270         
Leu Asn Gly Gly Gly Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn
        275                 280                 285             
Phe Thr Pro Asn Leu Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr
    290                 295                 300                 
Met Tyr Arg Cys Gly Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser
305                 310                 315                 320 
Ala Phe Arg Glu Gly Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro
                325                 330                 335     
Val Thr Leu Val Arg Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr
            340                 345                 350         
Phe Thr Tyr Thr Pro Glu Pro Gly Pro Arg Pro His Cys Ser Val Ala
        355                 360                 365             
Gly Ala Ile Leu Pro Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser
    370                 375                 380                 
Asn Thr Asn Ser Glu Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr
385                 390                 395                 400 
Ser Val Thr Ser Ser Thr Ala Thr Val Val Ser
                405                 410     


<210> 8556
<211> 485
<212> PRT
<213> Homo sapiens

<400> 8556
Met Gly Gly Cys Arg Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu
 1               5                  10                  15      
Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln Thr
            20                  25                  30          
Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu
        35                  40                  45              
Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser Gly
    50                  55                  60                  
Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu Gln
65                  70                  75                  80  
Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln Glu
                85                  90                  95      
Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys Thr
            100                 105                 110         
Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser Val
        115                 120                 125             
Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser Lys
    130                 135                 140                 
Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu Lys
145                 150                 155                 160 
Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe Asn
                165                 170                 175     
Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu Gly
            180                 185                 190         
Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile His
        195                 200                 205             
Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg Asp
    210                 215                 220                 
Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val Thr
225                 230                 235                 240 
Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln Thr
                245                 250                 255     
Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys Ala
            260                 265                 270         
Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln Glu
        275                 280                 285             
Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn Lys
    290                 295                 300                 
Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp Lys
305                 310                 315                 320 
Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro Val
                325                 330                 335     
Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly Asp
            340                 345                 350         
Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu Arg
        355                 360                 365             
Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly Glu
    370                 375                 380                 
Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly Trp
385                 390                 395                 400 
Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg Asn
                405                 410                 415     
Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro Glu
            420                 425                 430         
Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg Ala
        435                 440                 445             
Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu Gly
    450                 455                 460                 
Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser Thr
465                 470                 475                 480 
Ala Thr Val Val Ser
                485 


<210> 8557
<211> 46
<212> PRT
<213> Homo sapiens

<400> 8557
Met Thr Leu Thr Lys Gly Ser Phe Thr Tyr Ser Ser Gly Glu Glu Tyr
 1               5                  10                  15      
Arg Gly Glu Trp Lys Glu Gly Glu Lys Asp Pro Trp Gly Val Ser Met
            20                  25                  30          
Met Asn Thr Ser Phe Ala Gly Gly Gln Ile His Gln Asp Ile
        35                  40                  45      


<210> 8558
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8558
Met Ser Ile Ala Gly Val Ala Ala Gln Glu Ile Arg Val Pro Leu Lys
 1               5                  10                  15      
Thr Gly Phe Leu His Asn Gly Arg Ala Met Gly Asn Met Arg Lys Thr
            20                  25                  30          
Tyr Trp Ser Ser Arg Ser Glu Phe Lys Asn Asn Phe Leu Asn Ile Asp
        35                  40                  45              
Pro Ile Thr Met Ala Tyr Ser Leu Asn Ser Ser Ala Gln Glu Arg Leu
    50                  55                  60                  
Ile Pro Leu Gly His Ala Ser Lys Ser Ala Pro Met Asn Gly His Cys
65                  70                  75                  80  
Phe Ala Glu Asn Gly Pro Ser Gln Lys Ser Ser Leu Pro Pro Leu Leu
                85                  90                  95      
Ile Pro Pro Ser Glu Asn Leu Gly Pro His Glu Glu Asp Gln Val Val
            100                 105                 110         
Cys Gly Phe Lys Lys Leu Thr Val Asn Gly Val Cys Ala Ser Thr Pro
        115                 120                 125             
Pro Leu Thr Pro Ile Lys Asn Ser Pro Ser Leu Phe Pro Cys Ala Pro
    130                 135                 140                 
Leu Cys Glu Arg Gly Ser Arg Pro Leu Pro Pro Leu Pro Ile Ser Glu
145                 150                 155                 160 
Ala Leu Ser Leu Asp Asp Thr Asp Cys Glu Val Glu Phe Leu Thr Ser
                165                 170                 175     
Ser Asp Thr Asp Phe Leu Leu Glu Asp Ser Thr Leu Ser Asp Phe Lys
            180                 185                 190         
Tyr Asp Val Pro Gly Arg Arg Ser Phe Arg Gly Cys Gly Gln Ile Asn
        195                 200                 205             
Tyr Ala Tyr Phe Asp Thr Pro Ala Val Ser Ala Ala Asp Leu Ser Tyr
    210                 215                 220                 
Val Ser Asp Gln Asn Gly Gly Val Pro Asp Pro Asn Pro Pro Pro Pro
225                 230                 235                 240 
Gln Thr His Arg Arg Leu Arg Arg Ser His Ser Gly Pro Ala Gly Ser
                245                 250                 255     
Phe Asn Lys Pro Ala Ile Arg Ile Ser Asn Cys Cys Ile His Arg Ala
            260                 265                 270         
Ser Pro Asn Ser Asp Glu Asp Lys Pro Glu Val Pro Pro Arg Val Pro
        275                 280                 285             
Ile Pro Pro Arg Pro Val Lys Pro Asp Tyr Arg Arg Trp Ser Ala Glu
    290                 295                 300                 
Val Thr Ser Ser Thr Tyr Ser Asp Glu Asp Arg Pro Pro Lys Val Pro
305                 310                 315                 320 
Pro Arg Glu Pro Leu Ser Pro Ser Asn Ser Arg Thr Pro Ser Pro Lys
                325                 330                 335     
Ser Leu Pro Ser Tyr Leu Asn Gly Val Met Pro Pro Thr Gln Ser Phe
            340                 345                 350         
Ala Pro Asp Pro Lys Tyr Val Ser Ser Lys Ala Leu Gln Arg Gln Asn
        355                 360                 365             
Ser Glu Gly Ser Ala Ser Lys Val Pro Cys Ile Leu Pro Ile Ile Glu
    370                 375                 380                 
Asn Gly Lys Lys Val Ser Ser Thr His Tyr Tyr Leu Leu Pro Glu Arg
385                 390                 395                 400 
Pro Pro Tyr Leu Asp Lys Tyr Glu Lys Phe Phe Arg Glu Ala Glu Glu
                405                 410                 415     
Thr Asn Gly Gly Ala Gln Ile Gln Pro Leu Pro Ala Asp Cys Gly Ile
            420                 425                 430         
Ser Ser Ala Thr Glu Lys Pro Asp Ser Lys Thr Lys Met Asp Leu Gly
        435                 440                 445             
Gly His Val Lys Arg Lys His Leu Ser Tyr Val Val Ser Pro
    450                 455                 460         


<210> 8559
<211> 328
<212> PRT
<213> Homo sapiens

<400> 8559
Met Ser Met Leu Ala Glu Arg Arg Arg Lys Gln Lys Trp Ala Val Asp
 1               5                  10                  15      
Pro Gln Asn Thr Ala Trp Ser Asn Asp Asp Ser Lys Phe Gly Gln Arg
            20                  25                  30          
Met Leu Glu Lys Met Gly Trp Ser Lys Gly Lys Gly Leu Gly Ala Gln
        35                  40                  45              
Glu Gln Gly Ala Thr Asp His Ile Lys Val Gln Val Lys Asn Asn His
    50                  55                  60                  
Leu Gly Leu Gly Ala Thr Ile Asn Asn Glu Asp Asn Trp Ile Ala His
65                  70                  75                  80  
Gln Asp Asp Phe Asn Gln Leu Leu Ala Glu Leu Asn Thr Cys His Gly
                85                  90                  95      
Gln Glu Thr Thr Asp Ser Ser Asp Lys Lys Glu Lys Lys Ser Phe Ser
            100                 105                 110         
Leu Glu Glu Lys Ser Lys Ile Ser Lys Asn Arg Val His Tyr Met Lys
        115                 120                 125             
Phe Thr Lys Gly Lys Asp Leu Ser Ser Arg Ser Lys Thr Asp Leu Asp
    130                 135                 140                 
Cys Ile Phe Gly Lys Arg Gln Ser Lys Lys Thr Pro Glu Gly Asp Ala
145                 150                 155                 160 
Ser Pro Ser Thr Pro Glu Glu Asn Glu Thr Thr Thr Thr Ser Ala Phe
                165                 170                 175     
Thr Ile Gln Glu Tyr Phe Ala Lys Arg Met Ala Ala Leu Lys Asn Lys
            180                 185                 190         
Pro Gln Val Pro Val Pro Gly Ser Asp Ile Ser Glu Thr Gln Val Glu
        195                 200                 205             
Arg Lys Arg Gly Lys Lys Arg Asn Lys Glu Ala Thr Gly Lys Asp Val
    210                 215                 220                 
Glu Ser Tyr Leu Gln Pro Lys Ala Lys Arg His Thr Glu Gly Lys Pro
225                 230                 235                 240 
Glu Arg Ala Glu Ala Gln Glu Arg Val Ala Lys Lys Lys Ser Ala Pro
                245                 250                 255     
Ala Glu Glu Gln Leu Arg Gly Pro Cys Trp Asp Gln Ser Ser Lys Ala
            260                 265                 270         
Ser Ala Gln Asp Ala Gly Asp His Val Gln Pro Pro Glu Gly Arg Asp
        275                 280                 285             
Phe Thr Leu Lys Pro Lys Lys Arg Arg Gly Lys Lys Lys Leu Gln Lys
    290                 295                 300                 
Pro Val Glu Ile Ala Glu Asp Ala Thr Leu Glu Glu Thr Leu Val Lys
305                 310                 315                 320 
Lys Lys Lys Lys Lys Asp Ser Lys
                325             


<210> 8560
<211> 1209
<212> PRT
<213> Homo sapiens

<400> 8560
Gly Trp Arg Val Asp Leu Lys Asp Gln Gln Thr Val Ile Met Thr Glu
 1               5                  10                  15      
Cys Thr Ser Leu Gln Phe Val Ser Pro Phe Ala Phe Glu Ala Met Gln
            20                  25                  30          
Lys Val Asp Val Val Cys Leu Ala Ser Leu Ser Asp Pro Glu Leu Arg
        35                  40                  45              
Leu Leu Leu Pro Cys Leu Val Arg Met Ala Leu Cys Ala Pro Ala Asp
    50                  55                  60                  
Gln Ser Gln Ser Trp Ala Gln Asp Lys Lys Leu Ile Leu Arg Leu Leu
65                  70                  75                  80  
Ser Gly Val Glu Ala Val Asn Ser Ile Val Ala Leu Leu Ser Val Asp
                85                  90                  95      
Phe His Ala Leu Glu Gln Asp Ala Ser Lys Glu Gln Gln Leu Arg His
            100                 105                 110         
Lys Leu Gly Gly Gly Ser Gly Glu Ser Ile Leu Val Ser Gln Leu Gln
        115                 120                 125             
His Gly Leu Thr Leu Glu Phe Glu His Ser Asp Ser Pro Arg Arg Leu
    130                 135                 140                 
Arg Leu Val Leu Ser Glu Leu Leu Ala Ile Met Asn Lys Val Ser Glu
145                 150                 155                 160 
Ser Asn Gly Glu Phe Phe Phe Lys Ser Ser Glu Leu Phe Glu Ser Pro
                165                 170                 175     
Val Tyr Leu Glu Glu Ala Ala Asp Val Leu Cys Ile Leu Gln Ala Glu
            180                 185                 190         
Leu Pro Ser Leu Leu Pro Ile Val Asp Val Ala Glu Ala Leu Leu His
        195                 200                 205             
Val Arg Asn Gly Ala Trp Phe Leu Cys Leu Leu Val Ala Asn Val Pro
    210                 215                 220                 
Asp Ser Phe Asn Glu Val Cys Arg Gly Leu Ile Lys Asn Gly Glu Arg
225                 230                 235                 240 
Gln Asp Glu Glu Ser Leu Gly Gly Arg Arg Arg Thr Asp Ala Leu Arg
                245                 250                 255     
Phe Leu Cys Lys Met Asn Pro Ser Gln Ala Leu Lys Val Arg Gly Met
            260                 265                 270         
Val Val Glu Glu Cys His Leu Pro Gly Leu Gly Val Ala Leu Thr Leu
        275                 280                 285             
Asp His Thr Lys Asn Glu Ala Cys Glu Asp Gly Val Ser Asp Leu Val
    290                 295                 300                 
Cys Phe Val Ser Gly Leu Leu Leu Gly Thr Asn Ala Lys Val Arg Thr
305                 310                 315                 320 
Trp Phe Gly Thr Phe Ile Arg Asn Gly Gln Gln Arg Lys Arg Glu Thr
                325                 330                 335     
Ser Ser Ser Val Leu Trp Gln Met Arg Arg Gln Leu Leu Leu Glu Leu
            340                 345                 350         
Met Gly Ile Leu Pro Thr Val Arg Ser Thr Arg Ile Val Glu Glu Ala
        355                 360                 365             
Asp Val Asp Met Glu Pro Asn Val Ser Val Tyr Ser Gly Leu Lys Glu
    370                 375                 380                 
Glu His Val Val Lys Ala Ser Ala Leu Leu Arg Leu Tyr Cys Ala Leu
385                 390                 395                 400 
Met Gly Ile Ala Gly Leu Lys Pro Thr Glu Glu Glu Ala Glu Gln Leu
                405                 410                 415     
Leu Gln Leu Met Thr Ser Arg Pro Pro Ala Thr Pro Ala Gly Val Arg
            420                 425                 430         
Phe Val Ser Leu Ser Phe Cys Met Leu Leu Ala Phe Ser Thr Leu Val
        435                 440                 445             
Ser Thr Pro Glu Gln Glu Gln Leu Met Val Val Trp Leu Ser Trp Met
    450                 455                 460                 
Ile Lys Glu Glu Ala Tyr Phe Glu Ser Thr Ser Gly Val Ser Ala Ser
465                 470                 475                 480 
Phe Gly Glu Met Leu Leu Leu Val Ala Met Tyr Phe His Ser Asn Gln
                485                 490                 495     
Leu Ser Ala Ile Ile Asp Leu Val Cys Ser Thr Leu Gly Met Lys Ile
            500                 505                 510         
Val Ile Lys Pro Ser Ser Leu Ser Arg Met Lys Thr Ile Phe Thr Gln
        515                 520                 525             
Glu Ile Phe Thr Glu Gln Val Val Thr Ala His Ala Val Arg Val Pro
    530                 535                 540                 
Val Thr Ser Asn Leu Ser Ala Asn Ile Thr Gly Phe Leu Pro Ile His
545                 550                 555                 560 
Cys Ile Tyr Gln Leu Leu Arg Ser Arg Ser Phe Thr Lys His Lys Val
                565                 570                 575     
Ser Ile Lys Asp Trp Ile Tyr Arg Gln Leu Cys Glu Thr Ser Thr Pro
            580                 585                 590         
Leu His Pro Gln Leu Leu Pro Leu Ile Asp Val Tyr Ile Asn Ser Ile
        595                 600                 605             
Leu Thr Pro Ala Ser Lys Ser Asn Pro Glu Ala Thr Asn Gln Pro Val
    610                 615                 620                 
Thr Glu Gln Glu Ile Leu Asn Ile Phe Gln Gly Val Ile Gly Gly Asp
625                 630                 635                 640 
Asn Ile Arg Leu Asn Gln Arg Phe Ser Ile Thr Ala Gln Leu Leu Val
                645                 650                 655     
Leu Tyr Tyr Ile Leu Ser Tyr Glu Glu Ala Leu Leu Ala Asn Thr Lys
            660                 665                 670         
Thr Leu Ala Ala Met Gln Arg Lys Pro Lys Ser Tyr Ser Ser Ser Leu
        675                 680                 685             
Met Asp Gln Ile Pro Ile Lys Phe Leu Ile Arg Gln Ala Gln Gly Leu
    690                 695                 700                 
Gln Gln Glu Leu Gly Gly Leu His Ser Ala Leu Leu Arg Leu Leu Ala
705                 710                 715                 720 
Thr Asn Tyr Pro His Leu Cys Ile Val Asp Asp Trp Ile Cys Glu Glu
                725                 730                 735     
Glu Ile Thr Gly Thr Asp Ala Leu Leu Arg Arg Met Leu Leu Thr Asn
            740                 745                 750         
Asn Ala Lys Asn His Ser Pro Lys Gln Leu Gln Glu Ala Phe Ser Ala
        755                 760                 765             
Val Pro Val Asn His Thr Gln Val Met Gln Ile Ile Glu His Leu Thr
    770                 775                 780                 
Leu Leu Ser Ala Ser Glu Leu Ile Pro Tyr Ala Glu Val Leu Thr Ser
785                 790                 795                 800 
Asn Met Ser Gln Leu Leu Asn Ser Gly Val Pro Arg Arg Ile Leu Gln
                805                 810                 815     
Thr Val Asn Lys Leu Trp Met Val Leu Asn Thr Val Met Pro Arg Arg
            820                 825                 830         
Leu Trp Val Met Thr Val Asn Ala Leu Gln Pro Ser Ile Lys Phe Val
        835                 840                 845             
Arg Gln Gln Lys Tyr Thr Gln Asn Asp Leu Met Ile Asp Pro Leu Ile
    850                 855                 860                 
Val Leu Arg Cys Asp Gln Arg Val His Arg Cys Pro Pro Leu Met Asp
865                 870                 875                 880 
Ile Thr Leu His Met Leu Asn Gly Tyr Leu Leu Ala Ser Lys Ala Tyr
                885                 890                 895     
Leu Ser Ala His Leu Lys Glu Thr Glu Gln Asp Arg Pro Ser Gln Asn
            900                 905                 910         
Asn Thr Ile Gly Leu Val Gly Gln Thr Asp Ala Pro Glu Val Thr Arg
        915                 920                 925             
Glu Glu Leu Lys Asn Ala Leu Leu Ala Ala Gln Asp Ser Ala Ala Val
    930                 935                 940                 
Gln Ile Leu Leu Glu Ile Cys Leu Pro Thr Glu Glu Glu Lys Ala Asn
945                 950                 955                 960 
Gly Val Asn Pro Asp Ser Leu Leu Arg Asn Val Gln Ser Val Ile Thr
                965                 970                 975     
Thr Ser Ala Pro Asn Lys Gly Met Glu Glu Gly Glu Asp Asn Leu Leu
            980                 985                 990         
Cys Asn Leu Arg Glu Val Gln Cys Leu Ile Cys Cys Leu Leu His Gln
        995                 1000                1005            
Met Tyr Ile Ala Asp Pro Asn Ile Ala Lys Leu Val His Phe Gln Gly
    1010                1015                1020                
Tyr Pro Cys Glu Leu Leu Pro Leu Thr Val Ala Gly Ile Pro Ser Met
1025                1030                1035                1040
His Ile Cys Leu Asp Phe Ile Pro Glu Leu Ile Ala Gln Pro Glu Leu
                1045                1050                1055    
Glu Lys Gln Ile Phe Ala Ile Gln Leu Leu Ser His Leu Cys Ile Gln
            1060                1065                1070        
Tyr Ala Leu Pro Lys Ser Leu Ser Val Ala Arg Leu Ala Val Asn Val
        1075                1080                1085            
Met Gly Thr Leu Leu Thr Val Leu Thr Gln Ala Lys Arg Tyr Ala Phe
    1090                1095                1100                
Phe Met Pro Thr Leu Pro Ser Leu Val Ser Phe Cys Arg Ala Phe Pro
1105                1110                1115                1120
Pro Leu Tyr Glu Asp Ile Met Ser Leu Leu Ile Gln Ile Gly Gln Val
                1125                1130                1135    
Cys Ala Ser Asp Val Ala Thr Gln Thr Arg Asp Ile Asp Pro Ile Ile
            1140                1145                1150        
Thr Arg Leu Gln Gln Ile Lys Glu Lys Pro Ser Gly Trp Ser Gln Ile
        1155                1160                1165            
Cys Lys Asp Ser Ser Tyr Lys Asn Gly Ser Arg Asp Thr Gly Ser Met
    1170                1175                1180                
Asp Pro Asp Val Gln Leu Cys His Cys Ile Glu Arg Thr Val Ile Glu
1185                1190                1195                1200
Ile Ile Asn Met Ser Val Ser Gly Ile
                1205                


<210> 8561
<211> 1204
<212> PRT
<213> Homo sapiens

<400> 8561
Met Lys Asp Gln Gln Thr Val Ile Met Thr Glu Cys Thr Ser Leu Gln
 1               5                  10                  15      
Phe Val Ser Pro Phe Ala Phe Glu Ala Met Gln Lys Val Asp Val Val
            20                  25                  30          
Cys Leu Ala Ser Leu Ser Asp Pro Glu Leu Arg Leu Leu Leu Pro Cys
        35                  40                  45              
Leu Val Arg Met Ala Leu Cys Ala Pro Ala Asp Gln Ser Gln Ser Trp
    50                  55                  60                  
Ala Gln Asp Lys Lys Leu Ile Leu Arg Leu Leu Ser Gly Val Glu Ala
65                  70                  75                  80  
Val Asn Ser Ile Val Ala Leu Leu Ser Val Asp Phe His Ala Leu Glu
                85                  90                  95      
Gln Asp Ala Ser Lys Glu Gln Gln Leu Arg His Lys Leu Gly Gly Gly
            100                 105                 110         
Ser Gly Glu Ser Ile Leu Val Ser Gln Leu Gln His Gly Leu Thr Leu
        115                 120                 125             
Glu Phe Glu His Ser Asp Ser Pro Arg Arg Leu Arg Leu Val Leu Ser
    130                 135                 140                 
Glu Leu Leu Ala Ile Met Asn Lys Val Ser Glu Ser Asn Gly Glu Phe
145                 150                 155                 160 
Phe Phe Lys Ser Ser Glu Leu Phe Glu Ser Pro Val Tyr Leu Glu Glu
                165                 170                 175     
Ala Ala Asp Val Leu Cys Ile Leu Gln Ala Glu Leu Pro Ser Leu Leu
            180                 185                 190         
Pro Ile Val Asp Val Ala Glu Ala Leu Leu His Val Arg Asn Gly Ala
        195                 200                 205             
Trp Phe Leu Cys Leu Leu Val Ala Asn Val Pro Asp Ser Phe Asn Glu
    210                 215                 220                 
Val Cys Arg Gly Leu Ile Lys Asn Gly Glu Arg Gln Asp Glu Glu Ser
225                 230                 235                 240 
Leu Gly Gly Arg Arg Arg Thr Asp Ala Leu Arg Phe Leu Cys Lys Met
                245                 250                 255     
Asn Pro Ser Gln Ala Leu Lys Val Arg Gly Met Val Val Glu Glu Cys
            260                 265                 270         
His Leu Pro Gly Leu Gly Val Ala Leu Thr Leu Asp His Thr Lys Asn
        275                 280                 285             
Glu Ala Cys Glu Asp Gly Val Ser Asp Leu Val Cys Phe Val Ser Gly
    290                 295                 300                 
Leu Leu Leu Gly Thr Asn Ala Lys Val Arg Thr Trp Phe Gly Thr Phe
305                 310                 315                 320 
Ile Arg Asn Gly Gln Gln Arg Lys Arg Glu Thr Ser Ser Ser Val Leu
                325                 330                 335     
Trp Gln Met Arg Arg Gln Leu Leu Leu Glu Leu Met Gly Ile Leu Pro
            340                 345                 350         
Thr Val Arg Ser Thr Arg Ile Val Glu Glu Ala Asp Val Asp Met Glu
        355                 360                 365             
Pro Asn Val Ser Val Tyr Ser Gly Leu Lys Glu Glu His Val Val Lys
    370                 375                 380                 
Ala Ser Ala Leu Leu Arg Leu Tyr Cys Ala Leu Met Gly Ile Ala Gly
385                 390                 395                 400 
Leu Lys Pro Thr Glu Glu Glu Ala Glu Gln Leu Leu Gln Leu Met Thr
                405                 410                 415     
Ser Arg Pro Pro Ala Thr Pro Ala Gly Val Arg Phe Val Ser Leu Ser
            420                 425                 430         
Phe Cys Met Leu Leu Ala Phe Ser Thr Leu Val Ser Thr Pro Glu Gln
        435                 440                 445             
Glu Gln Leu Met Val Val Trp Leu Ser Trp Met Ile Lys Glu Glu Ala
    450                 455                 460                 
Tyr Phe Glu Ser Thr Ser Gly Val Ser Ala Ser Phe Gly Glu Met Leu
465                 470                 475                 480 
Leu Leu Val Ala Met Tyr Phe His Ser Asn Gln Leu Ser Ala Ile Ile
                485                 490                 495     
Asp Leu Val Cys Ser Thr Leu Gly Met Lys Ile Val Ile Lys Pro Ser
            500                 505                 510         
Ser Leu Ser Arg Met Lys Thr Ile Phe Thr Gln Glu Ile Phe Thr Glu
        515                 520                 525             
Gln Val Val Thr Ala His Ala Val Arg Val Pro Val Thr Ser Asn Leu
    530                 535                 540                 
Ser Ala Asn Ile Thr Gly Phe Leu Pro Ile His Cys Ile Tyr Gln Leu
545                 550                 555                 560 
Leu Arg Ser Arg Ser Phe Thr Lys His Lys Val Ser Ile Lys Asp Trp
                565                 570                 575     
Ile Tyr Arg Gln Leu Cys Glu Thr Ser Thr Pro Leu His Pro Gln Leu
            580                 585                 590         
Leu Pro Leu Ile Asp Val Tyr Ile Asn Ser Ile Leu Thr Pro Ala Ser
        595                 600                 605             
Lys Ser Asn Pro Glu Ala Thr Asn Gln Pro Val Thr Glu Gln Glu Ile
    610                 615                 620                 
Leu Asn Ile Phe Gln Gly Val Ile Gly Gly Asp Asn Ile Arg Leu Asn
625                 630                 635                 640 
Gln Arg Phe Ser Ile Thr Ala Gln Leu Leu Val Leu Tyr Tyr Ile Leu
                645                 650                 655     
Ser Tyr Glu Glu Ala Leu Leu Ala Asn Thr Lys Thr Leu Ala Ala Met
            660                 665                 670         
Gln Arg Lys Pro Lys Ser Tyr Ser Ser Ser Leu Met Asp Gln Ile Pro
        675                 680                 685             
Ile Lys Phe Leu Ile Arg Gln Ala Gln Gly Leu Gln Gln Glu Leu Gly
    690                 695                 700                 
Gly Leu His Ser Ala Leu Leu Arg Leu Leu Ala Thr Asn Tyr Pro His
705                 710                 715                 720 
Leu Cys Ile Val Asp Asp Trp Ile Cys Glu Glu Glu Ile Thr Gly Thr
                725                 730                 735     
Asp Ala Leu Leu Arg Arg Met Leu Leu Thr Asn Asn Ala Lys Asn His
            740                 745                 750         
Ser Pro Lys Gln Leu Gln Glu Ala Phe Ser Ala Val Pro Val Asn His
        755                 760                 765             
Thr Gln Val Met Gln Ile Ile Glu His Leu Thr Leu Leu Ser Ala Ser
    770                 775                 780                 
Glu Leu Ile Pro Tyr Ala Glu Val Leu Thr Ser Asn Met Ser Gln Leu
785                 790                 795                 800 
Leu Asn Ser Gly Val Pro Arg Arg Ile Leu Gln Thr Val Asn Lys Leu
                805                 810                 815     
Trp Met Val Leu Asn Thr Val Met Pro Arg Arg Leu Trp Val Met Thr
            820                 825                 830         
Val Asn Ala Leu Gln Pro Ser Ile Lys Phe Val Arg Gln Gln Lys Tyr
        835                 840                 845             
Thr Gln Asn Asp Leu Met Ile Asp Pro Leu Ile Val Leu Arg Cys Asp
    850                 855                 860                 
Gln Arg Val His Arg Cys Pro Pro Leu Met Asp Ile Thr Leu His Met
865                 870                 875                 880 
Leu Asn Gly Tyr Leu Leu Ala Ser Lys Ala Tyr Leu Ser Ala His Leu
                885                 890                 895     
Lys Glu Thr Glu Gln Asp Arg Pro Ser Gln Asn Asn Thr Ile Gly Leu
            900                 905                 910         
Val Gly Gln Thr Asp Ala Pro Glu Val Thr Arg Glu Glu Leu Lys Asn
        915                 920                 925             
Ala Leu Leu Ala Ala Gln Asp Ser Ala Ala Val Gln Ile Leu Leu Glu
    930                 935                 940                 
Ile Cys Leu Pro Thr Glu Glu Glu Lys Ala Asn Gly Val Asn Pro Asp
945                 950                 955                 960 
Ser Leu Leu Arg Asn Val Gln Ser Val Ile Thr Thr Ser Ala Pro Asn
                965                 970                 975     
Lys Gly Met Glu Glu Gly Glu Asp Asn Leu Leu Cys Asn Leu Arg Glu
            980                 985                 990         
Val Gln Cys Leu Ile Cys Cys Leu Leu His Gln Met Tyr Ile Ala Asp
        995                 1000                1005            
Pro Asn Ile Ala Lys Leu Val His Phe Gln Gly Tyr Pro Cys Glu Leu
    1010                1015                1020                
Leu Pro Leu Thr Val Ala Gly Ile Pro Ser Met His Ile Cys Leu Asp
1025                1030                1035                1040
Phe Ile Pro Glu Leu Ile Ala Gln Pro Glu Leu Glu Lys Gln Ile Phe
                1045                1050                1055    
Ala Ile Gln Leu Leu Ser His Leu Cys Ile Gln Tyr Ala Leu Pro Lys
            1060                1065                1070        
Ser Leu Ser Val Ala Arg Leu Ala Val Asn Val Met Gly Thr Leu Leu
        1075                1080                1085            
Thr Val Leu Thr Gln Ala Lys Arg Tyr Ala Phe Phe Met Pro Thr Leu
    1090                1095                1100                
Pro Ser Leu Val Ser Phe Cys Arg Ala Phe Pro Pro Leu Tyr Glu Asp
1105                1110                1115                1120
Ile Met Ser Leu Leu Ile Gln Ile Gly Gln Val Cys Ala Ser Asp Val
                1125                1130                1135    
Ala Thr Gln Thr Arg Asp Ile Asp Pro Ile Ile Thr Arg Leu Gln Gln
            1140                1145                1150        
Ile Lys Glu Lys Pro Ser Gly Trp Ser Gln Ile Cys Lys Asp Ser Ser
        1155                1160                1165            
Tyr Lys Asn Gly Ser Arg Asp Thr Gly Ser Met Asp Pro Asp Val Gln
    1170                1175                1180                
Leu Cys His Cys Ile Glu Arg Thr Val Ile Glu Ile Ile Asn Met Ser
1185                1190                1195                1200
Val Ser Gly Ile
                


<210> 8562
<211> 1148
<212> PRT
<213> Homo sapiens

<400> 8562
Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala
 1               5                  10                  15      
Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro
            20                  25                  30          
Ala Lys Asp Glu Glu Glu Val Ser Pro Pro Ser Ala Leu Pro Pro Gly
        35                  40                  45              
Leu Gly Ser Arg Ala Leu Glu Arg Lys Asp Ser Asp Trp Thr Leu Val
    50                  55                  60                  
Glu Thr Pro Pro Gly Glu Glu Gln Ala Lys Gln Asn Ala Asn Ser Gln
65                  70                  75                  80  
Leu Ser Ile Leu Phe Ile Glu Lys Pro Gln Gly Gly Thr Val Lys Val
                85                  90                  95      
Gly Glu Asp Ile Thr Phe Ile Ala Lys Val Lys Ala Glu Asp Leu Leu
            100                 105                 110         
Arg Lys Pro Thr Ile Lys Trp Phe Lys Gly Lys Trp Met Asp Leu Ala
        115                 120                 125             
Ser Lys Ala Gly Lys His Leu Gln Leu Lys Glu Thr Phe Glu Arg His
    130                 135                 140                 
Ser Arg Val Tyr Thr Phe Glu Met Gln Ile Ile Lys Ala Lys Asp Asn
145                 150                 155                 160 
Phe Ala Gly Asn Tyr Arg Cys Glu Val Thr Tyr Lys Asp Lys Phe Asp
                165                 170                 175     
Ser Cys Ser Phe Asp Leu Glu Val His Glu Ser Thr Gly Thr Thr Pro
            180                 185                 190         
Asn Ile Asp Ile Arg Ser Ala Phe Lys Arg Ser Gly Glu Gly Gln Glu
        195                 200                 205             
Asp Ala Gly Glu Leu Asp Phe Ser Gly Leu Leu Lys Arg Arg Glu Val
    210                 215                 220                 
Lys Gln Gln Glu Glu Glu Pro Gln Val Asp Val Trp Glu Leu Leu Lys
225                 230                 235                 240 
Asn Ala Lys Pro Ser Glu Tyr Glu Lys Ile Ala Phe Gln Tyr Gly Ile
                245                 250                 255     
Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys Arg Met Arg Arg Glu
            260                 265                 270         
Glu Lys Lys Ser Ala Ala Phe Ala Lys Ile Leu Asp Pro Ala Tyr Gln
        275                 280                 285             
Val Asp Lys Gly Gly Arg Val Arg Phe Val Val Glu Leu Ala Asp Pro
    290                 295                 300                 
Lys Leu Glu Val Lys Trp Tyr Lys Asn Gly Gln Glu Ile Arg Pro Ser
305                 310                 315                 320 
Thr Lys Tyr Ile Phe Glu His Lys Gly Cys Gln Arg Ile Leu Phe Ile
                325                 330                 335     
Asn Asn Cys Gln Met Thr Asp Asp Ser Glu Tyr Tyr Val Thr Ala Gly
            340                 345                 350         
Asp Glu Lys Cys Ser Thr Glu Leu Phe Val Arg Glu Pro Pro Ile Met
        355                 360                 365             
Val Thr Lys Gln Leu Glu Asp Thr Thr Ala Tyr Cys Gly Glu Arg Val
    370                 375                 380                 
Glu Leu Glu Cys Glu Val Ser Glu Asp Asp Ala Asn Val Lys Trp Phe
385                 390                 395                 400 
Lys Asn Gly Glu Glu Ile Ile Pro Gly Pro Lys Ser Arg Tyr Arg Ile
                405                 410                 415     
Arg Val Glu Gly Lys Lys His Ile Leu Ile Ile Glu Gly Ala Thr Lys
            420                 425                 430         
Ala Asp Ala Ala Glu Tyr Ser Val Met Thr Thr Gly Gly Gln Ser Ser
        435                 440                 445             
Ala Lys Leu Ser Val Asp Leu Lys Pro Leu Lys Ile Leu Thr Pro Leu
    450                 455                 460                 
Thr Asp Gln Thr Val Asn Leu Gly Lys Glu Ile Cys Leu Lys Cys Glu
465                 470                 475                 480 
Ile Ser Glu Asn Ile Pro Gly Lys Trp Thr Lys Asn Gly Leu Pro Val
                485                 490                 495     
Gln Glu Ser Asp Arg Leu Lys Val Val His Lys Gly Arg Ile His Lys
            500                 505                 510         
Leu Val Ile Ala Asn Ala Leu Thr Glu Asp Glu Gly Asp Tyr Val Phe
        515                 520                 525             
Ala Pro Asp Ala Tyr Asn Val Thr Leu Pro Ala Lys Val His Val Ile
    530                 535                 540                 
Asp Pro Pro Lys Ile Ile Leu Asp Gly Leu Asp Ala Asp Asn Thr Val
545                 550                 555                 560 
Thr Val Ile Ala Gly Asn Lys Leu Arg Leu Glu Ile Pro Ile Ser Gly
                565                 570                 575     
Glu Pro Pro Pro Lys Ala Met Trp Ser Arg Gly Asp Lys Ala Ile Met
            580                 585                 590         
Glu Gly Ser Gly Arg Ile Arg Thr Glu Ser Tyr Pro Asp Ser Ser Thr
        595                 600                 605             
Leu Val Ile Asp Ile Ala Glu Arg Asp Asp Ser Gly Val Tyr His Ile
    610                 615                 620                 
Asn Leu Lys Asn Glu Ala Gly Glu Ala His Ala Ser Ile Lys Val Lys
625                 630                 635                 640 
Val Val Asp Phe Pro Asp Pro Pro Val Ala Pro Thr Val Thr Glu Val
                645                 650                 655     
Gly Asp Asp Trp Cys Ile Met Asn Trp Glu Pro Pro Ala Tyr Asp Gly
            660                 665                 670         
Gly Ser Pro Ile Leu Gly Tyr Phe Ile Glu Arg Lys Lys Lys Gln Ser
        675                 680                 685             
Ser Arg Trp Met Arg Leu Asn Phe Asp Leu Cys Lys Glu Thr Thr Phe
    690                 695                 700                 
Glu Pro Lys Lys Met Ile Glu Gly Val Ala Tyr Glu Val Arg Ile Phe
705                 710                 715                 720 
Ala Val Asn Ala Ile Gly Ile Ser Lys Pro Ser Met Pro Ser Arg Pro
                725                 730                 735     
Phe Val Pro Leu Ala Val Thr Ser Pro Pro Thr Leu Leu Thr Val Asp
            740                 745                 750         
Ser Val Thr Asp Thr Thr Val Thr Met Arg Trp Arg Pro Pro Asp His
        755                 760                 765             
Ile Gly Ala Ala Gly Leu Asp Gly His Val Leu Glu Tyr Cys Phe Glu
    770                 775                 780                 
Gly Thr Glu Asp Trp Ile Val Ala Asn Lys Asp Leu Ile Asp Lys Thr
785                 790                 795                 800 
Lys Phe Thr Ile Thr Gly Leu Pro Thr Asp Ala Lys Ile Phe Val Arg
                805                 810                 815     
Val Lys Ala Val Asn Ala Ala Gly Ala Ser Glu Pro Lys Tyr Tyr Ser
            820                 825                 830         
Gln Pro Ile Leu Val Lys Glu Ile Ile Glu Pro Pro Lys Ile Arg Ile
        835                 840                 845             
Pro Arg His Leu Lys Gln Thr Tyr Ile Arg Arg Val Gly Glu Ala Val
    850                 855                 860                 
Asn Leu Val Ile Pro Phe Gln Gly Lys Pro Arg Pro Glu Leu Thr Trp
865                 870                 875                 880 
Lys Lys Asp Gly Ala Glu Ile Asp Lys Asn Gln Ile Asn Ile Arg Asn
                885                 890                 895     
Ser Glu Thr Asp Thr Ile Ile Phe Ile Arg Lys Ala Glu Arg Ser His
            900                 905                 910         
Ser Gly Lys Tyr Asp Leu Gln Val Lys Val Asp Lys Phe Val Glu Thr
        915                 920                 925             
Ala Ser Ile Asp Ile Gln Ile Ile Asp Arg Pro Gly Pro Pro Gln Ile
    930                 935                 940                 
Val Lys Ile Glu Asp Val Trp Gly Glu Asn Val Ala Leu Thr Trp Thr
945                 950                 955                 960 
Pro Pro Lys Asp Asp Gly Asn Ala Ala Ile Thr Gly Tyr Thr Ile Gln
                965                 970                 975     
Lys Ala Asp Lys Lys Ser Met Glu Trp Phe Thr Val Ile Glu His Tyr
            980                 985                 990         
His Arg Thr Ser Ala Thr Ile Thr Glu Leu Val Ile Gly Asn Glu Tyr
        995                 1000                1005            
Tyr Phe Arg Val Phe Ser Glu Asn Met Cys Gly Leu Ser Glu Asp Ala
    1010                1015                1020                
Thr Met Thr Lys Glu Ser Ala Val Ile Ala Arg Asp Gly Lys Ile Tyr
1025                1030                1035                1040
Lys Asn Pro Val Tyr Glu Asp Phe Asp Phe Ser Glu Ala Pro Met Phe
                1045                1050                1055    
Thr Gln Pro Leu Val Asn Thr Tyr Ala Ile Ala Gly Tyr Asn Ala Thr
            1060                1065                1070        
Leu Asn Cys Ser Val Arg Gly Asn Pro Lys Pro Lys Ile Thr Trp Met
        1075                1080                1085            
Lys Asn Lys Val Ala Ile Val Asp Asp Pro Arg Tyr Arg Met Phe Ser
    1090                1095                1100                
Asn Gln Gly Val Cys Thr Leu Glu Ile Arg Lys Pro Ser Pro Tyr Asp
1105                1110                1115                1120
Gly Gly Thr Tyr Cys Cys Lys Ala Val Asn Asp Leu Gly Thr Val Glu
                1125                1130                1135    
Ile Glu Cys Lys Leu Glu Val Lys Val Ile Ala Gln
            1140                1145            


<210> 8563
<211> 1141
<212> PRT
<213> Homo sapiens

<400> 8563
Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala
 1               5                  10                  15      
Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro
            20                  25                  30          
Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu Glu Gln Ala
        35                  40                  45              
Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile Glu Lys Pro
    50                  55                  60                  
Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe Ile Ala Lys
65                  70                  75                  80  
Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile Lys Trp Phe Lys
                85                  90                  95      
Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His Leu Gln Leu
            100                 105                 110         
Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe Glu Met Gln
        115                 120                 125             
Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg Cys Glu Val
    130                 135                 140                 
Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu Glu Val His
145                 150                 155                 160 
Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser Ala Phe Lys
                165                 170                 175     
Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu Asp Phe Ser Gly
            180                 185                 190         
Leu Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu Glu Pro Gln Val
        195                 200                 205             
Asp Val Trp Glu Leu Leu Lys Asn Ala Lys Pro Ser Glu Tyr Glu Lys
    210                 215                 220                 
Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu Arg Gly Met Leu Lys Arg
225                 230                 235                 240 
Leu Lys Arg Met Arg Arg Glu Glu Lys Lys Ser Ala Ala Phe Ala Lys
                245                 250                 255     
Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys Gly Gly Arg Val Arg Phe
            260                 265                 270         
Val Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys Trp Tyr Lys Asn
        275                 280                 285             
Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr Ile Phe Glu His Lys Gly
    290                 295                 300                 
Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys Gln Met Thr Asp Asp Ser
305                 310                 315                 320 
Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser Thr Glu Leu Phe
                325                 330                 335     
Val Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu Glu Asp Thr Thr
            340                 345                 350         
Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu Val Ser Glu Asp
        355                 360                 365             
Asp Ala Asn Val Lys Trp Phe Lys Asn Gly Glu Glu Ile Ile Pro Gly
    370                 375                 380                 
Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys His Ile Leu
385                 390                 395                 400 
Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala Ala Glu Tyr Ser Val Met
                405                 410                 415     
Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu Ser Val Asp Leu Lys Pro
            420                 425                 430         
Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln Thr Val Asn Leu Gly Lys
        435                 440                 445             
Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro Gly Lys Trp
    450                 455                 460                 
Thr Lys Asn Gly Leu Pro Val Gln Glu Ser Asp Arg Leu Lys Val Val
465                 470                 475                 480 
His Lys Gly Arg Ile His Lys Leu Val Ile Ala Asn Ala Leu Thr Glu
                485                 490                 495     
Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn Val Thr Leu
            500                 505                 510         
Pro Ala Lys Val His Val Ile Asp Pro Pro Lys Ile Ile Leu Asp Gly
        515                 520                 525             
Leu Asp Ala Asp Asn Thr Val Thr Val Ile Ala Gly Asn Lys Leu Arg
    530                 535                 540                 
Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala Met Trp Ser
545                 550                 555                 560 
Arg Gly Asp Lys Ala Ile Met Glu Gly Ser Gly Arg Ile Arg Thr Glu
                565                 570                 575     
Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile Asp Ile Ala Glu Arg Asp
            580                 585                 590         
Asp Ser Gly Val Tyr His Ile Asn Leu Lys Asn Glu Ala Gly Glu Ala
        595                 600                 605             
His Ala Ser Ile Lys Val Lys Val Val Asp Phe Pro Asp Pro Pro Val
    610                 615                 620                 
Ala Pro Thr Val Thr Glu Val Gly Asp Asp Trp Cys Ile Met Asn Trp
625                 630                 635                 640 
Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly Tyr Phe Ile
                645                 650                 655     
Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp Met Arg Leu Asn Phe Asp
            660                 665                 670         
Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys Lys Met Ile Glu Gly Val
        675                 680                 685             
Ala Tyr Glu Val Arg Ile Phe Ala Val Asn Ala Ile Gly Ile Ser Lys
    690                 695                 700                 
Pro Ser Met Pro Ser Arg Pro Phe Val Pro Leu Ala Val Thr Ser Pro
705                 710                 715                 720 
Pro Thr Leu Leu Thr Val Asp Ser Val Thr Asp Thr Thr Val Thr Met
                725                 730                 735     
Arg Trp Arg Pro Pro Asp His Ile Gly Ala Ala Gly Leu Asp Gly Tyr
            740                 745                 750         
Val Leu Glu Tyr Cys Phe Glu Gly Ser Thr Ser Ala Lys Gln Ser Asp
        755                 760                 765             
Glu Asn Gly Glu Ala Ala Tyr Asp Leu Pro Ala Glu Asp Trp Ile Val
    770                 775                 780                 
Ala Asn Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly Leu
785                 790                 795                 800 
Pro Thr Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn Ala Ala
                805                 810                 815     
Gly Ala Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys Glu
            820                 825                 830         
Ile Ile Glu Pro Pro Lys Ile Arg Ile Pro Arg His Leu Lys Gln Thr
        835                 840                 845             
Tyr Ile Arg Arg Val Gly Glu Ala Val Asn Leu Val Ile Pro Phe Gln
    850                 855                 860                 
Gly Lys Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu Ile
865                 870                 875                 880 
Asp Lys Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile Ile
                885                 890                 895     
Phe Ile Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp Leu Gln
            900                 905                 910         
Val Lys Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile Gln Ile
        915                 920                 925             
Ile Asp Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp Val Trp
    930                 935                 940                 
Gly Glu Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly Asn
945                 950                 955                 960 
Ala Ala Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser Met
                965                 970                 975     
Glu Trp Phe Thr Val Ile Glu His Tyr His Arg Thr Ser Ala Thr Ile
            980                 985                 990         
Thr Glu Leu Val Ile Gly Asn Glu Tyr Tyr Phe Arg Val Phe Ser Glu
        995                 1000                1005            
Asn Met Cys Gly Leu Ser Glu Asp Ala Thr Met Thr Lys Glu Ser Ala
    1010                1015                1020                
Val Ile Ala Arg Asp Gly Lys Ile Tyr Lys Asn Pro Val Tyr Glu Asp
1025                1030                1035                1040
Phe Asp Phe Ser Glu Ala Pro Met Phe Thr Gln Pro Leu Val Asn Thr
                1045                1050                1055    
Tyr Ala Ile Ala Gly Tyr Asn Ala Thr Leu Asn Cys Ser Val Arg Gly
            1060                1065                1070        
Asn Pro Lys Pro Lys Ile Thr Trp Met Lys Asn Lys Val Ala Ile Val
        1075                1080                1085            
Asp Asp Pro Arg Tyr Arg Met Phe Ser Asn Gln Gly Val Cys Thr Leu
    1090                1095                1100                
Glu Ile Arg Lys Pro Ser Pro Tyr Asp Gly Gly Thr Tyr Cys Cys Lys
1105                1110                1115                1120
Ala Val Asn Asp Leu Gly Thr Val Glu Ile Glu Cys Lys Leu Glu Val
                1125                1130                1135    
Lys Val Ile Ala Gln
            1140    


<210> 8564
<211> 1031
<212> PRT
<213> Homo sapiens

<400> 8564
Met Gly Phe Phe Ser Leu Ser Ser Glu Arg Asn Glu Ser Val Ile His
 1               5                  10                  15      
Tyr Pro Glu Ser Thr Glu Pro Glu Ile Gln Gln Glu Met Ser Thr Ser
            20                  25                  30          
Gln Pro Asp Cys Asn Val Asp Ser Cys Ser Val Ser Ser Gly Tyr Gly
        35                  40                  45              
Thr Phe Cys Ile Ser Glu Leu Asn Leu Tyr Lys Ser Lys Asp Pro Lys
    50                  55                  60                  
Glu Phe Met Glu His Ile Asp Val Pro Lys Gly Gln Tyr Val Ala Pro
65                  70                  75                  80  
Ala Val Pro Ala Glu Ser Leu Val Asp Gly Val Lys Asn Glu Asn Phe
                85                  90                  95      
Tyr Ile Gln Thr Pro Glu Glu Cys His Val Ser Leu Lys Glu Asp Val
            100                 105                 110         
Ser Ile Ser Pro Gly Glu Phe Glu His Asn Phe Leu Gly Glu Asn Lys
        115                 120                 125             
Val Ser Glu Val Tyr Ser Gly Lys Thr Asn Ser Asn Ala Ile Thr Ser
    130                 135                 140                 
Trp Ala Gln Lys Leu Lys Gln Asn Gln Pro Lys Arg Ala His Val Glu
145                 150                 155                 160 
Asp Gly Gly Ser Arg Ser Lys Gln Gly Asn Glu Gln Ser Lys Lys Thr
                165                 170                 175     
Pro Ile Glu Lys Ser Asp Phe Ala Ala Ala Thr His Pro Arg Ala Phe
            180                 185                 190         
Tyr Leu Ser Lys Pro Asp Glu Thr Pro Asn Ala Trp Met Ser Asp Ser
        195                 200                 205             
Gly Thr Gly Leu Thr Tyr Trp Lys Leu Glu Glu Lys Asp Met His His
    210                 215                 220                 
Ser Leu Pro Glu Thr Leu Glu Lys Thr Phe Ile Ser Leu Ser Ser Thr
225                 230                 235                 240 
Asp Val Ser Pro Asn Gln Ser Asn Thr Ser Asn Glu Met Lys Leu Pro
                245                 250                 255     
Ser Leu Lys Asp Ile Tyr Tyr Lys Lys Gln Arg Glu Asn Lys Gln Leu
            260                 265                 270         
Pro Glu Arg Asn Leu Thr Ser Ala Ser Asn Pro Asn His Pro Pro Glu
        275                 280                 285             
Val Leu Thr Leu Asp Pro Thr Leu His Met Lys Pro Lys Gln Gln Ile
    290                 295                 300                 
Ser Gly Ile Gln Pro His Gly Leu Pro Asn Ala Leu Asp Asp Arg Ile
305                 310                 315                 320 
Ser Phe Ser Pro Asp Ser Val Leu Glu Pro Ser Met Ser Ser Pro Ser
                325                 330                 335     
Asp Ile Asp Ser Phe Ser Gln Ala Ser Asn Val Thr Ser Gln Leu Pro
            340                 345                 350         
Gly Phe Pro Lys Tyr Pro Ser His Thr Lys Ala Ser Pro Val Asp Ser
        355                 360                 365             
Trp Lys Asn Gln Thr Phe Gln Asn Glu Ser Arg Thr Ser Ser Thr Phe
    370                 375                 380                 
Pro Ser Val Tyr Thr Ile Thr Ser Asn Asp Ile Ser Val Asn Thr Val
385                 390                 395                 400 
Asp Glu Glu Asn Thr Val Met Val Ala Ser Ala Ser Val Ser Gln Ser
                405                 410                 415     
Gln Leu Pro Gly Thr Ala Asn Ser Val Pro Glu Cys Ile Ser Leu Thr
            420                 425                 430         
Ser Leu Glu Asp Pro Val Ile Leu Ser Lys Ile Arg Gln Asn Leu Lys
        435                 440                 445             
Glu Lys His Ala Arg His Ile Ala Asp Leu Arg Ala Tyr Tyr Glu Ser
    450                 455                 460                 
Glu Ile Asn Ser Leu Lys Gln Lys Leu Glu Ala Lys Glu Ile Ser Gly
465                 470                 475                 480 
Val Glu Asp Trp Lys Ile Thr Asn Gln Ile Leu Val Asp Arg Cys Gly
                485                 490                 495     
Gln Leu Asp Ser Ala Leu His Glu Ala Thr Ser Arg Val Arg Thr Leu
            500                 505                 510         
Glu Asn Lys Asn Asn Leu Leu Glu Ile Glu Val Asn Asp Leu Arg Glu
        515                 520                 525             
Arg Phe Ser Ala Ala Ser Ser Ala Ser Lys Ile Leu Gln Glu Arg Ile
    530                 535                 540                 
Glu Glu Met Arg Thr Ser Ser Lys Glu Lys Asp Asn Thr Ile Ile Arg
545                 550                 555                 560 
Leu Lys Ser Arg Leu Gln Asp Leu Glu Glu Ala Phe Glu Asn Ala Tyr
                565                 570                 575     
Lys Leu Ser Asp Asp Lys Glu Ala Gln Leu Lys Gln Glu Asn Lys Met
            580                 585                 590         
Phe Gln Asp Leu Leu Gly Glu Tyr Glu Ser Leu Gly Lys Glu His Arg
        595                 600                 605             
Arg Val Lys Asp Ala Leu Asn Thr Thr Glu Asn Lys Leu Leu Asp Ala
    610                 615                 620                 
Tyr Thr Gln Ile Ser Asp Leu Lys Arg Met Ile Ser Lys Leu Glu Ala
625                 630                 635                 640 
Gln Val Lys Gln Val Glu His Glu Asn Met Leu Ser Leu Arg His Asn
                645                 650                 655     
Ser Arg Ile His Val Arg Pro Ser Arg Ala Asn Thr Leu Ala Thr Ser
            660                 665                 670         
Asp Val Ser Arg Arg Lys Trp Leu Ile Pro Gly Ala Glu Tyr Ser Ile
        675                 680                 685             
Phe Thr Gly Gln Pro Leu Asp Thr Gln Asp Ser Asn Val Asp Asn Gln
    690                 695                 700                 
Leu Glu Glu Thr Cys Ser Leu Gly His Arg Ser Pro Leu Glu Lys Asp
705                 710                 715                 720 
Ser Ser Pro Gly Ser Ser Ser Thr Ser Leu Leu Ile Lys Lys Gln Arg
                725                 730                 735     
Glu Thr Ser Asp Thr Pro Ile Met Arg Ala Leu Lys Glu Leu Asp Glu
            740                 745                 750         
Gly Lys Ile Phe Lys Asn Trp Gly Thr Gln Thr Glu Lys Glu Asp Thr
        755                 760                 765             
Ser Asn Ile Asn Pro Arg Gln Thr Glu Thr Ser Val Asn Ala Ser Arg
    770                 775                 780                 
Ser Pro Glu Lys Cys Ala Gln Gln Arg Gln Lys Arg Leu Asn Ser Ala
785                 790                 795                 800 
Ser Gln Arg Ser Ser Ser Leu Pro Pro Ser Asn Arg Lys Ser Ser Thr
                805                 810                 815     
Pro Thr Lys Arg Glu Ile Met Leu Thr Pro Val Thr Val Ala Tyr Ser
            820                 825                 830         
Pro Lys Arg Ser Pro Lys Glu Asn Leu Ser Pro Gly Phe Ser His Leu
        835                 840                 845             
Leu Ser Lys Asn Glu Ser Ser Pro Ile Arg Phe Asp Ile Leu Leu Asp
    850                 855                 860                 
Asp Leu Asp Thr Val Pro Val Ser Thr Leu Gln Arg Thr Asn Pro Arg
865                 870                 875                 880 
Lys Gln Leu Gln Phe Leu Pro Leu Asp Asp Ser Glu Glu Lys Thr Tyr
                885                 890                 895     
Ser Glu Lys Ala Thr Asp Asn His Val Asn His Ser Ser Cys Pro Glu
            900                 905                 910         
Pro Val Pro Asn Gly Val Lys Lys Val Ser Val Arg Thr Ala Trp Glu
        915                 920                 925             
Lys Asn Lys Ser Val Ser Tyr Glu Gln Cys Lys Pro Val Ser Val Thr
    930                 935                 940                 
Pro Gln Gly Asn Asp Phe Glu Tyr Thr Ala Lys Ile Arg Thr Leu Ala
945                 950                 955                 960 
Glu Thr Glu Arg Phe Phe Asp Glu Leu Thr Lys Glu Lys Asp Gln Ile
                965                 970                 975     
Glu Ala Ala Leu Ser Arg Met Pro Ser Pro Gly Gly Arg Ile Thr Leu
            980                 985                 990         
Gln Thr Arg Leu Asn Gln Glu Ala Leu Glu Asp Arg Leu Glu Arg Ile
        995                 1000                1005            
Asn Arg Glu Leu Gly Ser Val Arg Met Thr Leu Lys Lys Phe His Val
    1010                1015                1020                
Leu Arg Thr Ser Ala Asn Leu
1025                1030    


<210> 8565
<211> 561
<212> PRT
<213> Homo sapiens

<400> 8565
Met Trp Tyr Ile Ile Asp Glu Arg Gly Asp Ser Lys Glu Ser Pro Glu
 1               5                  10                  15      
Glu Asp Ala Gly Glu Pro Asn Gly Phe Ile Asp Cys Pro Ser Arg Ser
            20                  25                  30          
Ala Phe Pro Glu Phe Cys Pro Phe Gln Lys Glu Asp Gly Met Ile Lys
        35                  40                  45              
Phe Gln Glu Arg Val Ile Phe Lys Asp Val Ala Val Val Leu Thr Lys
    50                  55                  60                  
Glu Glu Leu Ala Leu Leu Asp Lys Ala Gln Ile Asn Leu Tyr Gln Asp
65                  70                  75                  80  
Val Met Leu Glu Asn Phe Arg Asn Leu Met Ser Asn Glu Thr Asp Lys
                85                  90                  95      
Ile His Thr Pro Pro Arg Thr Leu Ile Tyr Leu Leu Leu Leu Glu Lys
            100                 105                 110         
Ser Gln Cys Leu Ser Asn Val Leu Asp Lys Pro Val Leu Met Glu Ser
        115                 120                 125             
Trp Glu Asn Phe Asp Phe Val Gly Ser Tyr Asn Ser Gln His Leu Trp
    130                 135                 140                 
Val Tyr Lys Ser Trp Arg Lys Ala Asn Ile Met Thr Glu Pro Gln Asn
145                 150                 155                 160 
Ser Gln Gly Arg Tyr Lys Gly Ile Tyr Met Glu Glu Lys Leu Tyr Arg
                165                 170                 175     
Arg Ala Gln His Asp Asp Ser Leu Asn Trp Thr Ser His Asp His His
            180                 185                 190         
Glu Ser Gln Glu Cys Lys Gly Glu Asp Pro Gly Arg His Pro Asn Cys
        195                 200                 205             
Arg Lys Asn Phe Gly Met Lys Ser Thr Val Glu Gln His Asn Ala Val
    210                 215                 220                 
His Val Leu Pro Gln Pro Phe Thr Cys Asn Asn Cys Gly Val Pro Phe
225                 230                 235                 240 
Ala Asp Asp Thr Asp Pro His Val His His Ser Thr His Leu Gly Glu
                245                 250                 255     
Lys Ser Tyr Lys Cys Asp Gln Tyr Gly Lys Asn Phe Ser Gln Ser Gln
            260                 265                 270         
Asp Leu Ile Val His Cys Lys Thr His Ser Gly Glu Thr Pro Tyr Glu
        275                 280                 285             
Phe His Glu Trp Pro Met Gly Cys Lys Gln Ser Ser Asp Leu Pro Arg
    290                 295                 300                 
Tyr Gln Lys Val Pro Ser Gly Asn Lys Pro Tyr Lys Cys Lys Glu Cys
305                 310                 315                 320 
Gly Lys Gly Phe Arg Cys Asn Ser Phe Leu Tyr Asn His His Gly Val
                325                 330                 335     
His Thr Arg Glu Met Pro Tyr Lys Cys Asp Ala Cys Gly Lys Gly Phe
            340                 345                 350         
Gly Phe Arg Ser Leu Leu Cys Ile His Gln Gly Arg Val His Ala Gly
        355                 360                 365             
Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Cys Phe Ser Ser Ser
    370                 375                 380                 
Ser Val Leu Gln Val His Trp Arg Phe His Thr Gly Glu Lys Pro Tyr
385                 390                 395                 400 
Arg Cys Asp Glu Cys Gly Lys Gly Phe Ser Gln Ser Thr His Leu His
                405                 410                 415     
Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Val
            420                 425                 430         
Cys Gly Lys Asp Phe Ala Tyr Ser Ser Val Leu His Thr His Leu Ser
        435                 440                 445             
Ser Thr Arg Glu Lys Pro Tyr Lys Cys Lys Val Cys Gly Lys Cys Phe
    450                 455                 460                 
Ser Tyr Ser Ser Tyr Phe His Leu His Gln Arg Asp His Thr Arg Glu
465                 470                 475                 480 
Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asp Phe Ser Gln Asn Ser
                485                 490                 495     
Asp Leu Arg Val His Leu Arg Val His Thr Gly Glu Arg Pro Tyr Lys
            500                 505                 510         
Cys Lys Ala Cys Gly Lys Gly Phe Ser Arg Asn Ser Tyr Leu Leu Ala
        515                 520                 525             
His Gln Arg Val His Ile Asp Glu Thr Gln Tyr Thr His Cys Glu Arg
    530                 535                 540                 
Gly Lys Asp Leu Pro Thr His Gln Lys Leu His Lys Gln Arg Glu Thr
545                 550                 555                 560 
Leu
    


<210> 8566
<211> 590
<212> PRT
<213> Homo sapiens

<400> 8566
Met Ile Lys Phe Gln Glu Arg Val Thr Phe Lys Asp Val Ala Val Val
 1               5                  10                  15      
Phe Thr Lys Glu Glu Leu Ala Leu Leu Asp Lys Ala Gln Ile Asn Leu
            20                  25                  30          
Tyr Gln Asp Val Met Leu Glu Asn Phe Arg Asn Leu Met Leu Val Arg
        35                  40                  45              
Asp Gly Ile Lys Asn Asn Ile Leu Asn Leu Gln Ala Lys Gly Leu Ser
    50                  55                  60                  
Tyr Leu Ser Gln Glu Val Leu His Cys Trp Gln Ile Trp Lys Gln Arg
65                  70                  75                  80  
Ile Arg Asp Leu Thr Val Ser Gln Asp Tyr Ile Val Asn Leu Gln Glu
                85                  90                  95      
Glu Cys Ser Pro His Leu Glu Asp Val Ser Leu Ser Glu Glu Trp Ala
            100                 105                 110         
Gly Ile Ser Leu Gln Ile Ser Glu Asn Glu Asn Tyr Val Val Asn Ala
        115                 120                 125             
Ile Ile Lys Asn Gln Asp Ile Thr Ala Trp Gln Ser Leu Thr Gln Val
    130                 135                 140                 
Leu Thr Pro Glu Ser Trp Arg Lys Ala Asn Ile Met Thr Glu Pro Gln
145                 150                 155                 160 
Asn Ser Gln Gly Arg Tyr Lys Gly Ile Tyr Met Glu Glu Lys Leu Tyr
                165                 170                 175     
Arg Arg Ala Gln His Asp Asp Ser Leu Ser Trp Thr Ser Cys Asp His
            180                 185                 190         
His Glu Ser Gln Glu Cys Lys Gly Glu Asp Pro Gly Arg His Pro Ser
        195                 200                 205             
Cys Gly Lys Asn Leu Gly Met Lys Ser Thr Val Glu Lys Arg Asn Ala
    210                 215                 220                 
Ala His Val Leu Pro Gln Pro Phe Pro Cys Asn Asn Cys Gly Val Ala
225                 230                 235                 240 
Phe Ala Asp Asp Thr Asp Pro His Val His His Ser Thr His Leu Gly
                245                 250                 255     
Glu Lys Ser Tyr Lys Cys Asp Gln Tyr Gly Lys Asn Phe Ser Gln Ser
            260                 265                 270         
Gln Asp Leu Ile Val His Cys Lys Thr His Ser Gly Lys Thr Pro Tyr
        275                 280                 285             
Glu Phe His Glu Trp Pro Met Gly Cys Lys Gln Ser Ser Asp Leu Pro
    290                 295                 300                 
Arg Tyr Gln Lys Val Ser Ser Gly Asp Lys Pro Tyr Lys Cys Lys Glu
305                 310                 315                 320 
Cys Gly Lys Gly Phe Arg Arg Ser Ser Ser Leu His Asn His His Arg
                325                 330                 335     
Val His Thr Gly Glu Met Pro Tyr Lys Cys Asp Glu Cys Gly Lys Gly
            340                 345                 350         
Phe Gly Phe Arg Ser Leu Leu Cys Ile His Gln Gly Val His Thr Gly
        355                 360                 365             
Lys Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Asp Gln Ser
    370                 375                 380                 
Ser Asn Leu Leu Val His Gln Arg Val His Thr Gly Glu Lys Pro Tyr
385                 390                 395                 400 
Lys Cys Ser Glu Cys Gly Lys Cys Phe Ser Ser Ser Ser Val Leu Gln
                405                 410                 415     
Val His Trp Arg Phe His Thr Gly Glu Lys Pro Tyr Arg Cys Gly Glu
            420                 425                 430         
Cys Gly Lys Gly Phe Ser Gln Cys Thr His Leu His Ile His Gln Arg
        435                 440                 445             
Val His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Val Cys Gly Lys Asp
    450                 455                 460                 
Phe Ala Tyr Ser Ser Val Leu His Thr His Gln Arg Val His Thr Gly
465                 470                 475                 480 
Glu Lys Pro Tyr Lys Cys Glu Val Cys Gly Lys Cys Phe Ser Tyr Ser
                485                 490                 495     
Ser Tyr Phe His Leu His Gln Arg Asp His Ile Arg Glu Lys Pro Tyr
            500                 505                 510         
Lys Cys Asp Glu Cys Gly Lys Gly Phe Ser Arg Asn Ser Asp Leu Asn
        515                 520                 525             
Val His Leu Arg Val His Thr Arg Glu Arg Pro Tyr Lys Cys Lys Ala
    530                 535                 540                 
Cys Gly Lys Gly Phe Ser Arg Asn Ser Tyr Leu Leu Ala His Gln Arg
545                 550                 555                 560 
Val His Ile Asp Glu Thr Gln Tyr Thr His Cys Glu Arg Gly Lys Asp
                565                 570                 575     
Leu Leu Thr His Gln Arg Leu His Glu Gln Arg Glu Thr Leu
            580                 585                 590 


<210> 8567
<211> 328
<212> PRT
<213> Homo sapiens

<400> 8567
Met Asn Met Thr Ala Tyr Asn Lys Gly Arg Leu Gln Ser Ser Phe Trp
 1               5                  10                  15      
Ile Val Asp Lys Gln His Val Tyr Ile Gly Ser Ala Gly Leu Asp Trp
            20                  25                  30          
Gln Ser Leu Gly Gln Met Lys Glu Leu Gly Val Ile Phe Tyr Asn Cys
        35                  40                  45              
Ser Cys Leu Val Leu Asp Leu Gln Arg Ile Phe Ala Leu Tyr Ser Ser
    50                  55                  60                  
Leu Lys Phe Lys Ser Arg Val Pro Gln Thr Trp Ser Lys Arg Leu Tyr
65                  70                  75                  80  
Gly Val Tyr Asp Asn Glu Lys Lys Leu Gln Leu Gln Leu Asn Glu Thr
                85                  90                  95      
Lys Ser Gln Ala Phe Val Ser Asn Ser Pro Lys Leu Phe Cys Pro Lys
            100                 105                 110         
Asn Arg Ser Phe Asp Ile Asp Ala Ile Tyr Ser Val Ile Asp Asp Ala
        115                 120                 125             
Lys Gln Tyr Val Tyr Ile Ala Val Met Asp Tyr Leu Pro Ile Ser Ser
    130                 135                 140                 
Thr Ser Thr Lys Arg Thr Tyr Trp Pro Asp Leu Asp Ala Lys Ile Arg
145                 150                 155                 160 
Glu Ala Leu Val Leu Arg Ser Val Arg Val Arg Leu Leu Leu Ser Phe
                165                 170                 175     
Trp Lys Glu Thr Asp Pro Leu Thr Phe Asn Phe Ile Ser Ser Leu Lys
            180                 185                 190         
Ala Ile Cys Thr Glu Ile Ala Asn Cys Ser Leu Lys Val Lys Phe Phe
        195                 200                 205             
Asp Leu Glu Arg Glu Asn Ala Cys Ala Thr Lys Glu Gln Lys Asn His
    210                 215                 220                 
Thr Phe Pro Arg Leu Asn Arg Asn Lys Tyr Met Val Thr Asp Gly Ala
225                 230                 235                 240 
Ala Tyr Ile Gly Asn Phe Asp Trp Val Gly Asn Asp Phe Thr Gln Asn
                245                 250                 255     
Ala Gly Thr Gly Leu Val Ile Asn Gln Ala Asp Val Arg Asn Asn Arg
            260                 265                 270         
Ser Ile Ile Lys Gln Leu Lys Asp Val Phe Glu Arg Asp Trp Tyr Ser
        275                 280                 285             
Pro Tyr Ala Lys Thr Leu Gln Pro Thr Lys Gln Pro Asn Cys Ser Ser
    290                 295                 300                 
Leu Phe Lys Leu Lys Pro Leu Ser Asn Lys Thr Ala Thr Asp Asp Thr
305                 310                 315                 320 
Gly Gly Lys Asp Pro Arg Asn Val
                325             


<210> 8568
<211> 444
<212> PRT
<213> Homo sapiens

<400> 8568
Met Arg Met Asp Ser Gln Lys Lys Ile Ala Lys Ile Asn Val Gly Lys
 1               5                  10                  15      
Arg Ile Ala Leu Val Glu Asn Ile Pro Glu Gly Leu Asn Tyr Ser Glu
            20                  25                  30          
Asn Ala Pro Phe His Leu Ser Leu Phe Gln Gly Trp Met Asn Leu Leu
        35                  40                  45              
Asn Met Ala Lys Lys Ser Val Asp Ile Val Ser Ser His Trp Asp Leu
    50                  55                  60                  
Asn His Thr His Pro Ser Ala Cys Gln Gly Gln Arg Leu Phe Glu Lys
65                  70                  75                  80  
Leu Leu Gln Leu Thr Ser Gln Asn Ile Glu Ile Lys Leu Val Ser Asp
                85                  90                  95      
Val Thr Ala Asp Ser Lys Val Leu Glu Ala Leu Lys Leu Lys Gly Ala
            100                 105                 110         
Glu Val Thr Tyr Met Asn Met Thr Ala Tyr Asn Lys Gly Arg Leu Gln
        115                 120                 125             
Ser Ser Phe Trp Ile Val Asp Lys Gln His Val Tyr Ile Gly Ser Ala
    130                 135                 140                 
Gly Leu Asp Trp Gln Ser Leu Gly Gln Met Lys Glu Leu Gly Val Ile
145                 150                 155                 160 
Phe Tyr Asn Cys Ser Cys Leu Val Leu Asp Leu Gln Arg Ile Phe Ala
                165                 170                 175     
Leu Tyr Ser Ser Leu Lys Phe Lys Ser Arg Val Pro Gln Thr Trp Ser
            180                 185                 190         
Lys Arg Leu Tyr Gly Val Tyr Asp Asn Glu Lys Lys Leu Gln Leu Gln
        195                 200                 205             
Leu Asn Glu Thr Lys Ser Gln Ala Phe Val Ser Asn Ser Pro Lys Leu
    210                 215                 220                 
Phe Cys Pro Lys Asn Arg Ser Phe Asp Ile Asp Ala Ile Tyr Ser Val
225                 230                 235                 240 
Ile Asp Asp Ala Lys Gln Tyr Val Tyr Ile Ala Val Met Asp Tyr Leu
                245                 250                 255     
Pro Ile Ser Ser Thr Ser Thr Lys Arg Thr Tyr Trp Pro Asp Leu Asp
            260                 265                 270         
Ala Lys Ile Arg Glu Ala Leu Val Leu Arg Ser Val Arg Val Arg Leu
        275                 280                 285             
Leu Leu Ser Phe Trp Lys Glu Thr Asp Pro Leu Thr Phe Asn Phe Ile
    290                 295                 300                 
Ser Ser Leu Lys Ala Ile Cys Thr Glu Ile Ala Asn Cys Ser Leu Lys
305                 310                 315                 320 
Val Lys Phe Phe Asp Leu Glu Arg Glu Asn Ala Cys Ala Thr Lys Glu
                325                 330                 335     
Gln Lys Asn His Thr Phe Pro Arg Leu Asn Arg Asn Lys Tyr Met Val
            340                 345                 350         
Thr Asp Gly Ala Ala Tyr Ile Gly Asn Phe Asp Trp Val Gly Asn Asp
        355                 360                 365             
Phe Thr Gln Asn Ala Gly Thr Gly Leu Val Ile Asn Gln Ala Asp Val
    370                 375                 380                 
Arg Asn Asn Arg Ser Ile Ile Lys Gln Leu Lys Asp Val Phe Glu Arg
385                 390                 395                 400 
Asp Trp Tyr Ser Pro Tyr Ala Lys Thr Leu Gln Pro Thr Lys Gln Pro
                405                 410                 415     
Asn Cys Ser Ser Leu Phe Lys Leu Lys Pro Leu Ser Asn Lys Thr Ala
            420                 425                 430         
Thr Asp Asp Thr Gly Gly Lys Asp Pro Arg Asn Val
        435                 440                 


<210> 8569
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 8569
Met Lys Gln Pro Ile Met Ala Asp Gly Pro Arg Cys Lys Arg Arg Lys
 1               5                  10                  15      
Gln Ala Asn Pro Arg Arg Lys Asn Val Val Asn Tyr Asp Asn Val Val
            20                  25                  30          
Asp Thr Gly Ser Glu Thr Asp Glu Glu Asp Lys Leu His Ile Ala Glu
        35                  40                  45              
Asp Asp Gly Ile Ala Asn Pro Leu Asp Gln Glu Thr Ser Pro Ala Ser
    50                  55                  60                  
Val Pro Asn His Glu Ser Ser Pro His Val Ser Gln Ala Leu Leu Pro
65                  70                  75                  80  
Arg Glu Glu Glu Glu Asp Glu Ile Arg Glu Gly Gly Val Glu His Pro
                85                  90                  95      
Trp His Asn Asn Glu Ile Leu Gln Ala Ser Val Asp Gly Pro Glu Glu
            100                 105                 110         
Met Lys Glu Asp Tyr Asp Thr Met Gly Pro Glu Ala Thr Ile Gln Thr
        115                 120                 125             
Ala Ile Asn Asn Gly Thr Val Lys Asn Ala Asn Cys Thr Ser Asp Phe
    130                 135                 140                 
Glu Glu Tyr Phe Ala Lys Arg Lys Leu Glu Glu Arg Asp Gly His Ala
145                 150                 155                 160 
Val Ser Ile Glu Glu Tyr Leu Gln Arg Ser Asp Thr Ala Ile Ile Tyr
                165                 170                 175     
Pro Glu Ala Pro Glu Glu Leu Ser Arg Leu Gly Thr Pro Glu Ala Asn
            180                 185                 190         
Gly Gln Glu Glu Asn Asp Leu Pro Pro Gly Thr Pro Asp Ala Phe Ala
        195                 200                 205             
Gln Leu Leu Thr Cys Pro Tyr Cys Asp Arg Gly Tyr Lys Arg Leu Thr
    210                 215                 220                 
Ser Leu Lys Glu His Ile Lys Tyr Arg His Glu Lys Asn Glu Glu Asn
225                 230                 235                 240 
Phe Ser Cys Pro Leu Cys Ser Tyr Thr Phe Ala Tyr Arg Thr Gln Leu
                245                 250                 255     
Glu Arg His Met Val Thr His Lys Pro Gly Thr Asp Gln His Gln Met
            260                 265                 270         
Leu Thr Gln Gly Ala Gly Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly
        275                 280                 285             
Lys Ala Phe Lys Tyr Lys His His Leu Lys Glu His Leu Arg Ile His
    290                 295                 300                 
Ser Gly Glu Lys Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser
305                 310                 315                 320 
His Ser Gly Ser Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Gly
                325                 330                 335     
Leu Ile Ser Val Asn Gly Arg Met Arg Asn Asn Ile Lys Thr Gly Ser
            340                 345                 350         
Ser Pro Asn Ser Val Ser Ser Ser Pro Thr Asn Ser Ala Ile Thr Gln
        355                 360                 365             
Leu Arg Asn Lys Leu Glu Asn Gly Lys Pro Leu Ser Met Ser Glu Gln
    370                 375                 380                 
Thr Gly Leu Leu Lys Ile Lys Thr Glu Pro Leu Asp Phe Asn Asp Tyr
385                 390                 395                 400 
Lys Val Leu Met Ala Thr His Gly Phe Ser Gly Thr Ser Pro Phe Met
                405                 410                 415     
Asn Gly Gly Leu Gly Ala Thr Ser Pro Leu Gly Val His Pro Ser Ala
            420                 425                 430         
Gln Ser Pro Met Gln His Leu Gly Val Gly Met Glu Ala Pro Leu Leu
        435                 440                 445             
Gly Phe Pro Thr Met Asn Ser Asn Leu Ser Glu Val Gln Lys Val Leu
    450                 455                 460                 
Gln Ile Val Asp Asn Thr Val Ser Arg Gln Lys Met Asp Cys Lys Ala
465                 470                 475                 480 
Glu Glu Ile Ser Lys Leu Lys Gly Tyr His Met Lys Asp Pro Cys Ser
                485                 490                 495     
Gln Pro Glu Glu Gln Gly Val Thr Ser Pro Asn Ile Pro Pro Val Gly
            500                 505                 510         
Leu Pro Val Val Ser His Asn Gly Ala Thr Lys Ser Ile Ile Asp Tyr
        515                 520                 525             
Thr Leu Glu Lys Val Asn Glu Ala Lys Ala Cys Leu Gln Ser Leu Thr
    530                 535                 540                 
Thr Asp Ser Arg Arg Gln Ile Ser Asn Ile Lys Lys Glu Lys Leu Arg
545                 550                 555                 560 
Thr Leu Ile Asp Leu Val Thr Asp Asp Lys Met Ile Glu Asn His Asn
                565                 570                 575     
Ile Ser Thr Pro Phe Ser Cys Gln Phe Cys Lys Glu Ser Phe Pro Gly
            580                 585                 590         
Pro Ile Pro Leu His Gln His Glu Arg Tyr Leu Cys Lys Met Asn Glu
        595                 600                 605             
Glu Ile Lys Ala Val Leu Gln Pro His Glu Asn Ile Val Pro Asn Lys
    610                 615                 620                 
Ala Gly Val Phe Val Asp Asn Lys Ala Leu Leu Leu Ser Ser Val Leu
625                 630                 635                 640 
Ser Glu Lys Gly Met Thr Ser Pro Ile Asn Pro Tyr Lys Asp His Met
                645                 650                 655     
Ser Val Leu Lys Ala Tyr Tyr Ala Met Asn Met Glu Pro Asn Ser Asp
            660                 665                 670         
Glu Leu Leu Lys Ile Ser Ile Ala Val Gly Leu Pro Gln Glu Phe Val
        675                 680                 685             
Lys Glu Trp Phe Glu Gln Arg Lys Val Tyr Gln Tyr Ser Asn Ser Arg
    690                 695                 700                 
Ser Pro Ser Leu Glu Arg Ser Ser Lys Pro Leu Ala Pro Asn Ser Asn
705                 710                 715                 720 
Pro Pro Thr Lys Asp Ser Leu Leu Pro Arg Ser Pro Val Lys Pro Met
                725                 730                 735     
Asp Ser Ile Thr Ser Pro Ser Ile Ala Glu Leu His Asn Ser Val Thr
            740                 745                 750         
Asn Cys Asp Pro Pro Leu Arg Leu Thr Lys Pro Ser His Phe Thr Asn
        755                 760                 765             
Ile Lys Pro Val Glu Lys Leu Asp His Ser Arg Ser Asn Thr Pro Ser
    770                 775                 780                 
Pro Leu Asn Leu Ser Ser Thr Ser Ser Lys Asn Ser His Ser Ser Ser
785                 790                 795                 800 
Tyr Thr Pro Asn Ser Phe Ser Ser Glu Glu Leu Gln Ala Glu Pro Leu
                805                 810                 815     
Asp Leu Ser Leu Pro Lys Gln Met Lys Glu Pro Lys Ser Ile Ile Ala
            820                 825                 830         
Thr Lys Asn Lys Thr Lys Ala Ser Ser Ile Ser Leu Asp His Asn Ser
        835                 840                 845             
Val Ser Ser Ser Ser Glu Asn Ser Asp Glu Pro Leu Asn Leu Thr Phe
    850                 855                 860                 
Ile Lys Lys Glu Phe Ser Asn Ser Asn Asn Leu Asp Asn Lys Ser Thr
865                 870                 875                 880 
Asn Pro Val Phe Ser Met Asn Pro Phe Ser Ala Lys Pro Leu Tyr Thr
                885                 890                 895     
Ala Leu Pro Pro Gln Ser Ala Phe Pro Pro Ala Thr Phe Met Pro Pro
            900                 905                 910         
Val Gln Thr Ser Ile Pro Gly Leu Arg Pro Tyr Pro Gly Leu Asp Gln
        915                 920                 925             
Met Ser Phe Leu Pro His Met Ala Tyr Thr Tyr Pro Thr Gly Ala Ala
    930                 935                 940                 
Thr Phe Ala Asp Met Gln Gln Arg Arg Lys Tyr Gln Arg Lys Gln Gly
945                 950                 955                 960 
Phe Gln Gly Glu Leu Leu Asp Gly Ala Gln Asp Tyr Met Ser Gly Leu
                965                 970                 975     
Asp Asp Met Thr Asp Ser Asp Ser Cys Leu Ser Arg Lys Lys Ile Lys
            980                 985                 990         
Lys Thr Glu Ser Gly Met Tyr Ala Cys Asp Leu Cys Asp Lys Thr Phe
        995                 1000                1005            
Gln Lys Ser Ser Ser Leu Leu Arg His Lys Tyr Glu His Thr Gly Lys
    1010                1015                1020                
Arg Pro His Gln Cys Gln Ile Cys Lys Lys Ala Phe Lys His Lys His
1025                1030                1035                1040
His Leu Ile Glu His Ser Arg Leu His Ser Gly Glu Lys Pro Tyr Gln
                1045                1050                1055    
Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Gln
            1060                1065                1070        
His Met Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala Glu Glu Arg
        1075                1080                1085            
Glu Ala Ala Glu Arg Glu Ala Arg Glu Lys Gly His Leu Glu Pro Thr
    1090                1095                1100                
Glu Leu Leu Met Asn Arg Ala Tyr Leu Gln Ser Ile Thr Pro Gln Gly
1105                1110                1115                1120
Tyr Ser Asp Ser Glu Glu Arg Glu Ser Met Pro Arg Asp Gly Glu Ser
                1125                1130                1135    
Glu Lys Glu His Glu Lys Glu Gly Glu Asp Gly Tyr Gly Lys Leu Gly
            1140                1145                1150        
Arg Gln Asp Gly Asp Glu Glu Phe Glu Glu Glu Glu Glu Glu Ser Glu
        1155                1160                1165            
Asn Lys Ser Met Asp Thr Asp Pro Glu Thr Ile Arg Asp Glu Glu Glu
    1170                1175                1180                
Thr Gly Asp His Ser Met Asp Asp Ser Ser Glu Asp Gly Lys Met Glu
1185                1190                1195                1200
Thr Lys Ser Asp His Glu Glu Asp Asn Met Glu Asp Gly Met
                1205                1210                


<210> 8570
<211> 1748
<212> PRT
<213> Homo sapiens

<400> 8570
Met Ser Ala Arg Ala Ala Ala Ala Lys Ser Thr Ala Met Glu Glu Thr
 1               5                  10                  15      
Ala Ile Trp Glu Gln His Thr Val Thr Leu His Arg Ala Pro Gly Phe
            20                  25                  30          
Gly Phe Gly Ile Ala Ile Ser Gly Gly Arg Asp Asn Pro His Phe Gln
        35                  40                  45              
Ser Gly Glu Thr Ser Ile Val Ile Ser Asp Val Leu Lys Gly Gly Pro
    50                  55                  60                  
Ala Glu Gly Gln Leu Gln Glu Asn Asp Arg Val Ala Met Val Asn Gly
65                  70                  75                  80  
Val Ser Met Asp Asn Val Glu His Ala Phe Ala Val Gln Gln Leu Arg
                85                  90                  95      
Lys Ser Gly Lys Asn Ala Lys Ile Thr Ile Arg Arg Lys Lys Lys Val
            100                 105                 110         
Gln Ile Pro Val Ser Arg Pro Asp Pro Glu Pro Val Ser Asp Asn Glu
        115                 120                 125             
Glu Asp Ser Tyr Asp Glu Glu Ile His Asp Pro Arg Ser Gly Arg Ser
    130                 135                 140                 
Gly Val Val Asn Arg Arg Ser Glu Lys Ile Trp Pro Arg Asp Arg Ser
145                 150                 155                 160 
Ala Ser Arg Glu Arg Ser Leu Ser Pro Arg Ser Asp Arg Arg Ser Val
                165                 170                 175     
Ala Ser Ser Gln Pro Ala Lys Pro Thr Lys Val Thr Leu Val Lys Ser
            180                 185                 190         
Arg Lys Asn Glu Glu Tyr Gly Leu Arg Leu Ala Ser His Ile Phe Val
        195                 200                 205             
Lys Glu Ile Ser Gln Asp Ser Leu Ala Ala Arg Asp Gly Asn Ile Gln
    210                 215                 220                 
Glu Gly Asp Val Val Leu Lys Ile Asn Gly Thr Val Thr Glu Asn Met
225                 230                 235                 240 
Ser Leu Thr Asp Ala Lys Thr Leu Ile Glu Arg Ser Lys Gly Lys Leu
                245                 250                 255     
Lys Met Val Val Gln Arg Asp Glu Arg Ala Thr Leu Leu Asn Val Pro
            260                 265                 270         
Asp Leu Ser Asp Ser Ile His Ser Ala Asn Ala Ser Glu Arg Asp Asp
        275                 280                 285             
Ile Ser Glu Ile Gln Ser Leu Ala Ser Asp His Ser Gly Arg Ser His
    290                 295                 300                 
Asp Arg Pro Pro Arg Arg Ser Arg Ser Arg Ser Pro Asp Gln Arg Ser
305                 310                 315                 320 
Glu Pro Ser Asp His Ser Arg His Ser Pro Gln Gln Pro Ser Asn Gly
                325                 330                 335     
Ser Leu Arg Ser Arg Asp Glu Glu Arg Ile Ser Lys Pro Gly Ala Val
            340                 345                 350         
Ser Thr Pro Val Lys His Ala Asp Asp His Thr Pro Lys Thr Val Glu
        355                 360                 365             
Glu Val Thr Val Glu Arg Asn Glu Lys Gln Thr Pro Ser Leu Pro Glu
    370                 375                 380                 
Pro Lys Pro Val Tyr Ala Gln Val Gly Asn Gln Met Trp Ile Tyr Leu
385                 390                 395                 400 
Ser Val His Leu Met Val Ser Tyr Leu Ile Gln Leu Met Lys Met Gly
                405                 410                 415     
Phe Leu Arg Pro Ser Met Lys Leu Val Lys Phe Arg Lys Gly Asp Ser
            420                 425                 430         
Val Gly Leu Arg Leu Ala Gly Gly Asn Asp Val Gly Ile Phe Val Ala
        435                 440                 445             
Gly Val Leu Glu Asp Ser Pro Ala Ala Lys Glu Gly Leu Glu Glu Gly
    450                 455                 460                 
Asp Gln Ile Leu Arg Val Asn Asn Val Asp Phe Thr Asn Ile Ile Arg
465                 470                 475                 480 
Glu Glu Ala Val Leu Phe Leu Leu Asp Leu Pro Lys Gly Glu Glu Val
                485                 490                 495     
Thr Ile Leu Ala Gln Lys Lys Lys Asp Val Tyr Arg Arg Ile Val Glu
            500                 505                 510         
Ser Asp Val Gly Asp Ser Phe Tyr Ile Arg Thr His Phe Glu Tyr Glu
        515                 520                 525             
Lys Glu Ser Pro Tyr Gly Leu Ser Phe Asn Lys Gly Glu Val Phe Arg
    530                 535                 540                 
Val Val Asp Thr Leu Tyr Asn Gly Lys Leu Gly Ser Trp Leu Ala Ile
545                 550                 555                 560 
Arg Ile Gly Lys Asn His Lys Glu Val Glu Arg Gly Ile Ile Pro Asn
                565                 570                 575     
Lys Asn Arg Ala Glu Gln Leu Ala Ser Val Gln Tyr Thr Leu Pro Lys
            580                 585                 590         
Thr Ala Gly Gly Asp Arg Ala Asp Phe Trp Arg Phe Arg Gly Leu Arg
        595                 600                 605             
Ser Ser Lys Arg Asn Leu Arg Lys Ser Arg Glu Asp Leu Ser Ala Gln
    610                 615                 620                 
Pro Val Gln Thr Lys Phe Pro Ala Tyr Glu Arg Val Val Leu Arg Glu
625                 630                 635                 640 
Ala Gly Phe Leu Arg Pro Val Thr Ile Phe Gly Pro Ile Ala Asp Val
                645                 650                 655     
Ala Arg Glu Lys Leu Ala Arg Glu Glu Pro Asp Ile Tyr Gln Ile Ala
            660                 665                 670         
Lys Ser Glu Pro Arg Asp Ala Gly Thr Asp Gln Arg Ser Ser Gly Ile
        675                 680                 685             
Ile Arg Leu His Thr Ile Lys Gln Ile Ile Asp Gln Asp Lys His Ala
    690                 695                 700                 
Leu Leu Asp Val Thr Pro Asn Ala Val Asp Arg Leu Asn Tyr Ala Gln
705                 710                 715                 720 
Trp Tyr Pro Ile Val Val Phe Leu Asn Pro Asp Ser Lys Gln Gly Val
                725                 730                 735     
Lys Thr Met Arg Met Arg Leu Cys Pro Glu Ser Arg Lys Ser Ala Arg
            740                 745                 750         
Lys Leu Tyr Glu Arg Ser His Lys Leu Arg Lys Asn Asn His His Leu
        755                 760                 765             
Phe Thr Thr Thr Ile Asn Leu Asn Ser Met Asn Asp Gly Trp Tyr Gly
    770                 775                 780                 
Ala Leu Lys Glu Ala Ile Gln Gln Gln Gln Asn Gln Leu Val Trp Val
785                 790                 795                 800 
Ser Glu Gly Lys Ala Asp Gly Ala Thr Ser Asp Asp Leu Asp Leu His
                805                 810                 815     
Asp Asp Arg Leu Ser Tyr Leu Ser Ala Pro Gly Ser Glu Tyr Ser Met
            820                 825                 830         
Tyr Ser Thr Asp Ser Arg His Thr Ser Asp Tyr Glu Asp Thr Asp Thr
        835                 840                 845             
Glu Gly Gly Ala Tyr Thr Asp Gln Glu Leu Asp Glu Thr Leu Asn Asp
    850                 855                 860                 
Glu Val Gly Thr Pro Pro Glu Ser Ala Ile Thr Arg Ser Ser Glu Pro
865                 870                 875                 880 
Val Arg Glu Asp Ser Ser Gly Met His His Glu Asn Gln Thr Tyr Pro
                885                 890                 895     
Pro Tyr Ser Pro Gln Ala Gln Pro Gln Pro Ile His Arg Ile Asp Ser
            900                 905                 910         
Pro Gly Phe Lys Pro Ala Ser Gln Gln Lys Ala Glu Ala Ser Ser Pro
        915                 920                 925             
Val Pro Tyr Leu Ser Pro Glu Thr Asn Pro Ala Ser Ser Thr Ser Ala
    930                 935                 940                 
Val Asn His Asn Val Asn Leu Thr Asn Val Arg Leu Glu Glu Pro Thr
945                 950                 955                 960 
Pro Ala Pro Ser Thr Ser Tyr Ser Pro Gln Ala Asp Ser Leu Arg Thr
                965                 970                 975     
Pro Ser Thr Glu Ala Ala His Ile Met Leu Arg Asp Gln Glu Pro Ser
            980                 985                 990         
Leu Ser Ser His Val Asp Pro Thr Lys Val Tyr Arg Lys Asp Pro Tyr
        995                 1000                1005            
Pro Glu Glu Met Met Arg Gln Asn His Val Leu Lys Gln Pro Ala Val
    1010                1015                1020                
Ser His Pro Gly His Arg Pro Asp Lys Glu Pro Asn Leu Thr Tyr Glu
1025                1030                1035                1040
Pro Gln Leu Pro Tyr Val Glu Lys Gln Ala Ser Arg Asp Leu Glu Gln
                1045                1050                1055    
Pro Thr Tyr Arg Tyr Glu Ser Ser Ser Tyr Thr Asp Gln Phe Ser Arg
            1060                1065                1070        
Asn Tyr Glu His Arg Leu Arg Tyr Glu Asp Arg Val Pro Met Tyr Glu
        1075                1080                1085            
Glu Gln Trp Ser Tyr Tyr Asp Asp Lys Gln Pro Tyr Pro Ser Arg Pro
    1090                1095                1100                
Pro Phe Asp Asn Gln His Ser Gln Asp Leu Asp Ser Arg Gln His Pro
1105                1110                1115                1120
Glu Glu Ser Ser Glu Arg Gly Tyr Phe Pro Arg Phe Glu Glu Pro Ala
                1125                1130                1135    
Pro Leu Ser Tyr Asp Ser Arg Pro Arg Tyr Glu Gln Ala Pro Arg Ala
            1140                1145                1150        
Ser Ala Leu Arg His Glu Glu Gln Pro Ala Pro Gly Tyr Asp Thr His
        1155                1160                1165            
Gly Arg Leu Arg Pro Glu Ala Gln Pro His Pro Ser Ala Gly Pro Lys
    1170                1175                1180                
Pro Ala Glu Ser Lys Gln Tyr Phe Glu Gln Tyr Ser Arg Ser Tyr Glu
1185                1190                1195                1200
Gln Val Pro Pro Gln Gly Phe Thr Ser Arg Ala Gly His Phe Glu Pro
                1205                1210                1215    
Leu His Gly Ala Ala Ala Val Pro Pro Leu Ile Pro Ser Ser Gln His
            1220                1225                1230        
Lys Pro Glu Ala Leu Pro Ser Asn Thr Lys Pro Leu Pro Pro Pro Pro
        1235                1240                1245            
Thr Gln Thr Glu Glu Glu Glu Asp Pro Ala Met Lys Pro Gln Ser Val
    1250                1255                1260                
Leu Thr Arg Val Lys Met Phe Glu Asn Lys Arg Ser Ala Ser Leu Glu
1265                1270                1275                1280
Thr Lys Lys Asp Val Asn Asp Thr Gly Ser Phe Lys Pro Pro Glu Val
                1285                1290                1295    
Ala Ser Lys Pro Ser Gly Ala Pro Ile Ile Gly Pro Lys Pro Thr Ser
            1300                1305                1310        
Gln Asn Gln Phe Ser Glu His Asp Lys Thr Leu Tyr Arg Ile Pro Glu
        1315                1320                1325            
Pro Gln Lys Pro Gln Leu Lys Pro Pro Glu Asp Ile Val Arg Ser Asn
    1330                1335                1340                
His Tyr Asp Pro Glu Glu Asp Glu Glu Tyr Tyr Arg Lys Gln Leu Ser
1345                1350                1355                1360
Tyr Phe Asp Arg Arg Ser Phe Glu Asn Lys Pro Pro Ala His Ile Ala
                1365                1370                1375    
Ala Ser His Leu Ser Glu Pro Ala Lys Pro Ala His Ser Gln Asn Gln
            1380                1385                1390        
Ser Asn Phe Ser Ser Tyr Ser Ser Lys Gly Lys Pro Pro Glu Ala Asp
        1395                1400                1405            
Gly Val Asp Arg Ser Phe Gly Glu Lys Arg Tyr Glu Pro Ile Gln Ala
    1410                1415                1420                
Thr Pro Pro Pro Pro Pro Leu Pro Ser Gln Tyr Ala Gln Pro Ser Gln
1425                1430                1435                1440
Pro Val Thr Ser Ala Ser Leu His Ile His Ser Lys Gly Ala His Gly
                1445                1450                1455    
Glu Gly Asn Ser Val Ser Leu Asp Phe Gln Asn Ser Leu Val Ser Lys
            1460                1465                1470        
Pro Asp Pro Pro Pro Ser Gln Asn Lys Pro Ala Thr Phe Arg Pro Pro
        1475                1480                1485            
Asn Arg Glu Asp Thr Ala Gln Ala Ala Phe Tyr Pro Gln Lys Ser Phe
    1490                1495                1500                
Pro Asp Lys Ala Pro Val Asn Gly Thr Glu Gln Thr Gln Lys Thr Val
1505                1510                1515                1520
Thr Pro Ala Tyr Asn Arg Phe Thr Pro Lys Pro Tyr Thr Ser Ser Ala
                1525                1530                1535    
Arg Pro Phe Glu Arg Lys Phe Glu Ser Pro Lys Phe Asn His Asn Leu
            1540                1545                1550        
Leu Pro Ser Glu Thr Ala His Lys Pro Asp Leu Ser Ser Lys Thr Pro
        1555                1560                1565            
Thr Ser Pro Lys Thr Leu Val Lys Ser His Ser Leu Ala Gln Pro Pro
    1570                1575                1580                
Glu Phe Asp Ser Gly Val Glu Thr Phe Ser Ile His Ala Glu Lys Pro
1585                1590                1595                1600
Lys Tyr Gln Ile Asn Asn Ile Ser Thr Val Pro Lys Ala Ile Pro Val
                1605                1610                1615    
Ser Pro Ser Ala Val Glu Glu Asp Glu Asp Glu Asp Gly His Thr Val
            1620                1625                1630        
Val Ala Thr Ala Arg Gly Ile Phe Asn Ser Asn Gly Gly Val Leu Ser
        1635                1640                1645            
Ser Ile Glu Thr Gly Val Ser Ile Ile Ile Pro Gln Gly Ala Ile Pro
    1650                1655                1660                
Glu Gly Val Glu Gln Glu Ile Tyr Phe Lys Val Cys Arg Asp Asn Ser
1665                1670                1675                1680
Ile Leu Pro Pro Leu Asp Lys Glu Lys Gly Glu Thr Leu Leu Ser Pro
                1685                1690                1695    
Leu Val Met Cys Gly Pro His Gly Leu Lys Phe Leu Lys Pro Val Glu
            1700                1705                1710        
Leu Arg Leu Pro His Cys Asp Pro Lys Thr Trp Gln Asn Lys Cys Leu
        1715                1720                1725            
Pro Gly Asp Pro Asn Tyr Leu Val Gly Ala Asn Cys Val Ser Val Leu
    1730                1735                1740                
Ile Asp His Phe
1745            


<210> 8571
<211> 1656
<212> PRT
<213> Homo sapiens

<400> 8571
Met Glu Glu Thr Ala Ile Trp Glu Gln His Thr Val Thr Leu His Arg
 1               5                  10                  15      
Ala Pro Gly Phe Gly Phe Gly Ile Ala Ile Ser Gly Gly Arg Asp Asn
            20                  25                  30          
Pro His Phe Gln Ser Gly Glu Thr Ser Ile Val Ile Ser Asp Val Leu
        35                  40                  45              
Lys Gly Gly Pro Ala Glu Gly Gln Leu Gln Glu Asn Asp Arg Val Ala
    50                  55                  60                  
Met Val Asn Gly Val Ser Met Asp Asn Val Glu His Ala Phe Ala Val
65                  70                  75                  80  
Gln Gln Leu Arg Lys Ser Gly Lys Asn Ala Lys Ile Thr Ile Arg Arg
                85                  90                  95      
Lys Lys Lys Val Gln Ile Pro Val Ser Arg Pro Asp Pro Glu Pro Val
            100                 105                 110         
Ser Asp Asn Glu Glu Asp Ser Tyr Asp Glu Glu Ile His Asp Pro Arg
        115                 120                 125             
Ser Gly Arg Ser Gly Val Val Asn Arg Arg Ser Glu Lys Ile Trp Pro
    130                 135                 140                 
Arg Asp Arg Ser Ala Ser Arg Glu Arg Ser Leu Ser Pro Arg Ser Asp
145                 150                 155                 160 
Arg Arg Ser Val Ala Ser Ser Gln Pro Ala Lys Pro Thr Lys Val Thr
                165                 170                 175     
Leu Val Lys Ser Arg Lys Asn Glu Glu Tyr Gly Leu Arg Leu Ala Ser
            180                 185                 190         
His Ile Phe Val Lys Glu Ile Ser Gln Asp Ser Leu Ala Ala Arg Asp
        195                 200                 205             
Gly Asn Ile Gln Glu Gly Asp Val Val Leu Lys Ile Asn Gly Thr Val
    210                 215                 220                 
Thr Glu Asn Met Ser Leu Thr Asp Ala Lys Thr Leu Ile Glu Arg Ser
225                 230                 235                 240 
Lys Gly Lys Leu Lys Met Val Val Gln Arg Asp Glu Arg Ala Thr Leu
                245                 250                 255     
Leu Asn Val Pro Asp Leu Ser Asp Ser Ile His Ser Ala Asn Ala Ser
            260                 265                 270         
Glu Arg Asp Asp Ile Ser Glu Ile Gln Ser Leu Ala Ser Asp His Ser
        275                 280                 285             
Gly Arg Ser His Asp Arg Pro Pro Arg Arg Ser Arg Ser Arg Ser Pro
    290                 295                 300                 
Asp Gln Arg Ser Glu Pro Ser Asp His Ser Arg His Ser Pro Gln Gln
305                 310                 315                 320 
Pro Ser Asn Gly Ser Leu Arg Ser Arg Asp Glu Glu Arg Ile Ser Lys
                325                 330                 335     
Pro Gly Ala Val Ser Thr Pro Val Lys His Ala Asp Asp His Thr Pro
            340                 345                 350         
Lys Thr Val Glu Glu Val Thr Val Glu Arg Asn Glu Lys Gln Thr Pro
        355                 360                 365             
Ser Leu Pro Glu Pro Lys Pro Val Tyr Ala Gln Val Gly Asn Gln Met
    370                 375                 380                 
Trp Ile Tyr Leu Ser Val His Leu Met Val Ser Tyr Leu Ile Gln Leu
385                 390                 395                 400 
Met Lys Met Gly Phe Leu Arg Pro Ser Met Lys Leu Val Lys Phe Arg
                405                 410                 415     
Lys Gly Asp Ser Val Gly Leu Arg Leu Ala Gly Gly Asn Asp Val Gly
            420                 425                 430         
Ile Phe Val Ala Gly Val Leu Glu Asp Ser Pro Ala Ala Lys Glu Gly
        435                 440                 445             
Leu Glu Glu Gly Asp Gln Ile Leu Arg Val Asn Asn Val Asp Phe Thr
    450                 455                 460                 
Asn Ile Ile Arg Glu Glu Ala Val Leu Phe Leu Leu Asp Leu Pro Lys
465                 470                 475                 480 
Gly Glu Glu Val Thr Ile Leu Ala Gln Lys Lys Lys Asp Val Tyr Arg
                485                 490                 495     
Arg Ile Val Glu Ser Asp Val Gly Asp Ser Phe Tyr Ile Arg Thr His
            500                 505                 510         
Phe Glu Tyr Glu Lys Glu Ser Pro Tyr Gly Leu Ser Phe Asn Lys Gly
        515                 520                 525             
Glu Val Phe Arg Ala Val Asp Thr Leu Tyr Asn Gly Lys Leu Gly Ser
    530                 535                 540                 
Trp Leu Ala Ile Arg Ile Gly Lys Asn His Lys Glu Val Glu Arg Gly
545                 550                 555                 560 
Ile Ile Pro Asn Lys Asn Arg Ala Glu Gln Leu Ala Ser Val Gln Tyr
                565                 570                 575     
Thr Leu Pro Lys Thr Ala Gly Gly Asp Arg Ala Asp Phe Trp Arg Phe
            580                 585                 590         
Arg Gly Leu Arg Ser Ser Lys Arg Asn Leu Arg Lys Ser Arg Glu Asp
        595                 600                 605             
Leu Ser Ala Gln Pro Val Gln Thr Lys Phe Pro Ala Tyr Glu Arg Val
    610                 615                 620                 
Val Leu Arg Glu Ala Gly Phe Leu Arg Pro Val Thr Ile Phe Gly Pro
625                 630                 635                 640 
Ile Ala Asp Val Ala Arg Glu Lys Leu Ala Arg Glu Glu Pro Asp Ile
                645                 650                 655     
Tyr Gln Ile Ala Lys Ser Glu Pro Arg Asp Ala Gly Thr Asp Gln Arg
            660                 665                 670         
Ser Ser Gly Tyr Ile Arg Leu His Thr Ile Lys Gln Ile Ile Asp Gln
        675                 680                 685             
Asp Lys His Ala Leu Leu Asp Val Thr Pro Asn Ala Val Asp Arg Leu
    690                 695                 700                 
Asn Tyr Ala Gln Trp Tyr Pro Ile Val Val Phe Leu Asn Pro Asp Ser
705                 710                 715                 720 
Lys Gln Gly Val Lys Thr Met Arg Met Arg Leu Cys Pro Glu Ser Arg
                725                 730                 735     
Lys Ser Ala Arg Lys Leu Tyr Glu Arg Ser His Lys Leu Ala Lys Asn
            740                 745                 750         
Asn His His Leu Phe Thr Thr Thr Ile Asn Leu Asn Ser Met Asn Asp
        755                 760                 765             
Gly Trp Tyr Gly Ala Leu Lys Glu Ala Val Gln Gln Gln Gln Asn Gln
    770                 775                 780                 
Leu Val Trp Val Ser Glu Gly Lys Ala Asp Gly Ala Thr Ser Asp Asp
785                 790                 795                 800 
Leu Asp Leu His Asp Asp Arg Leu Ser Tyr Leu Ser Ala Pro Gly Ser
                805                 810                 815     
Glu Tyr Ser Met Tyr Ser Thr Asp Ser Arg His Thr Ser Asp Tyr Glu
            820                 825                 830         
Asp Thr Asp Thr Glu Gly Gly Ala Tyr Thr Asp Gln Glu Leu Asp Glu
        835                 840                 845             
Thr Leu Asn Asp Glu Val Gly Thr Pro Pro Glu Ser Ala Ile Thr Arg
    850                 855                 860                 
Ser Ser Glu Pro Val Arg Glu Asp Ser Ser Gly Met His His Glu Asn
865                 870                 875                 880 
Gln Thr Tyr Pro Pro Tyr Ser Pro Gln Ala Gln Pro Gln Pro Ile His
                885                 890                 895     
Arg Ile Asp Ser Pro Gly Phe Lys Pro Ala Ser Gln Gln Val Tyr Arg
            900                 905                 910         
Lys Asp Pro Tyr Pro Glu Glu Met Met Arg Gln Asn His Val Leu Lys
        915                 920                 925             
Gln Pro Ala Val Ser His Pro Gly His Arg Pro Asp Lys Glu Pro Asn
    930                 935                 940                 
Leu Thr Tyr Glu Pro Gln Leu Pro Tyr Val Glu Lys Gln Ala Ser Arg
945                 950                 955                 960 
Asp Leu Glu Gln Pro Thr Tyr Arg Tyr Glu Ser Ser Ser Tyr Thr Asp
                965                 970                 975     
Gln Phe Ser Arg Asn Tyr Glu His Arg Leu Arg Tyr Glu Asp Arg Val
            980                 985                 990         
Pro Met Tyr Glu Glu Gln Trp Ser Tyr Tyr Asp Asp Lys Gln Pro Tyr
        995                 1000                1005            
Pro Ser Arg Pro Pro Phe Asp Asn Gln His Ser Gln Asp Leu Asp Ser
    1010                1015                1020                
Arg Gln His Pro Glu Glu Ser Ser Glu Arg Gly Tyr Phe Pro Arg Phe
1025                1030                1035                1040
Glu Glu Pro Ala Pro Leu Ser Tyr Asp Ser Arg Pro Arg Tyr Glu Gln
                1045                1050                1055    
Ala Pro Arg Ala Ser Ala Leu Arg His Glu Glu Gln Pro Ala Pro Gly
            1060                1065                1070        
Tyr Asp Thr His Gly Arg Leu Arg Pro Glu Ala Gln Pro His Pro Ser
        1075                1080                1085            
Ala Gly Pro Lys Pro Ala Glu Ser Lys Gln Tyr Phe Glu Gln Tyr Ser
    1090                1095                1100                
Arg Ser Tyr Glu Gln Val Pro Pro Gln Gly Phe Thr Ser Arg Ala Gly
1105                1110                1115                1120
His Phe Glu Pro Leu His Gly Ala Ala Ala Val Pro Pro Leu Ile Pro
                1125                1130                1135    
Ser Ser Gln His Lys Pro Glu Ala Leu Pro Ser Asn Thr Lys Pro Leu
            1140                1145                1150        
Pro Pro Pro Pro Thr Gln Thr Glu Glu Glu Glu Asp Pro Ala Met Lys
        1155                1160                1165            
Pro Gln Ser Val Leu Thr Arg Val Lys Met Phe Glu Asn Lys Arg Ser
    1170                1175                1180                
Ala Ser Leu Glu Thr Lys Lys Asp Val Asn Asp Thr Gly Ser Phe Lys
1185                1190                1195                1200
Pro Pro Glu Val Ala Ser Lys Pro Ser Gly Ala Pro Ile Ile Gly Pro
                1205                1210                1215    
Lys Pro Thr Ser Gln Asn Gln Phe Ser Glu His Asp Lys Thr Leu Tyr
            1220                1225                1230        
Arg Ile Pro Glu Pro Gln Lys Pro Gln Leu Lys Pro Pro Glu Asp Ile
        1235                1240                1245            
Val Arg Ser Asn His Tyr Asp Pro Glu Glu Asp Glu Glu Tyr Tyr Arg
    1250                1255                1260                
Lys Gln Leu Ser Tyr Phe Asp Arg Arg Ser Phe Glu Asn Lys Pro Pro
1265                1270                1275                1280
Ala His Ile Ala Ala Ser His Leu Ser Glu Pro Ala Lys Pro Ala His
                1285                1290                1295    
Ser Gln Asn Gln Ser Asn Phe Ser Ser Tyr Ser Ser Lys Gly Lys Pro
            1300                1305                1310        
Pro Glu Ala Asp Gly Val Asp Arg Ser Phe Gly Glu Lys Arg Tyr Glu
        1315                1320                1325            
Pro Ile Gln Ala Thr Pro Pro Pro Pro Pro Leu Pro Ser Gln Tyr Ala
    1330                1335                1340                
Gln Pro Ser Gln Pro Val Thr Ser Ala Ser Leu His Ile His Ser Lys
1345                1350                1355                1360
Gly Ala His Gly Glu Gly Asn Ser Val Ser Leu Asp Phe Gln Asn Ser
                1365                1370                1375    
Leu Val Ser Lys Pro Asp Pro Pro Pro Ser Gln Asn Lys Pro Ala Thr
            1380                1385                1390        
Phe Arg Pro Pro Asn Arg Glu Asp Thr Ala Gln Ala Ala Phe Tyr Pro
        1395                1400                1405            
Gln Lys Ser Phe Pro Asp Lys Ala Pro Val Asn Gly Thr Glu Gln Thr
    1410                1415                1420                
Gln Lys Thr Val Thr Pro Ala Tyr Asn Arg Phe Thr Pro Lys Pro Tyr
1425                1430                1435                1440
Thr Ser Ser Ala Arg Pro Phe Glu Arg Lys Phe Glu Ser Pro Lys Phe
                1445                1450                1455    
Asn His Asn Leu Leu Pro Ser Glu Thr Ala His Lys Pro Asp Leu Ser
            1460                1465                1470        
Ser Lys Thr Pro Thr Ser Pro Lys Thr Leu Val Lys Ser His Ser Leu
        1475                1480                1485            
Ala Gln Pro Pro Glu Phe Asp Ser Gly Val Glu Thr Phe Ser Ile His
    1490                1495                1500                
Ala Glu Lys Pro Lys Tyr Gln Ile Asn Asn Ile Ser Thr Val Pro Lys
1505                1510                1515                1520
Ala Ile Pro Val Ser Pro Ser Ala Val Glu Glu Asp Glu Asp Glu Asp
                1525                1530                1535    
Gly His Thr Val Val Ala Thr Ala Arg Gly Ile Phe Asn Ser Asn Gly
            1540                1545                1550        
Gly Val Leu Ser Ser Ile Glu Thr Gly Val Ser Ile Ile Ile Pro Gln
        1555                1560                1565            
Gly Ala Ile Pro Glu Gly Val Glu Gln Glu Ile Tyr Phe Lys Val Cys
    1570                1575                1580                
Arg Asp Asn Ser Ile Leu Pro Pro Leu Asp Lys Glu Lys Gly Glu Thr
1585                1590                1595                1600
Leu Leu Ser Pro Leu Val Met Cys Gly Pro His Gly Leu Lys Phe Leu
                1605                1610                1615    
Lys Pro Val Glu Leu Arg Leu Pro His Cys Asp Pro Lys Thr Trp Gln
            1620                1625                1630        
Asn Lys Cys Leu Pro Gly Asp Pro Asn Tyr Leu Val Gly Ala Asn Cys
        1635                1640                1645            
Val Ser Val Leu Ile Asp His Phe
    1650                1655    


<210> 8572
<211> 441
<212> PRT
<213> Homo sapiens

<400> 8572
Met Glu Ile Arg Leu Asp Thr Leu Ser Ala Ser Leu Gly Arg Ser Ser
 1               5                  10                  15      
Thr Leu Asn Asp Cys Asn Leu Glu Asp Lys Leu Ala Trp Tyr Glu Gly
            20                  25                  30          
Glu Ala Tyr Met Trp His His Trp Lys Pro Phe Pro Glu Asn Pro Leu
        35                  40                  45              
Trp Thr Cys Leu Asp Phe Gln Ile Ala Gln Val Gly Pro Trp Asp Tyr
    50                  55                  60                  
Cys Ser Ser Cys Ile Arg His Thr Arg Leu Lys Ser Ser Cys Ser Asp
65                  70                  75                  80  
Met Asp Leu Leu His Ser Trp Arg Ser Ser Ser Phe Gly Asn Phe Asp
                85                  90                  95      
Arg Phe Arg Asn Asn Ser Leu Ser Lys Pro Asp Asp Ser Thr Glu Ala
            100                 105                 110         
His Glu Gly Asp Pro Thr Asn Gly Ser Gly Glu Gln Ser Lys Thr Ser
        115                 120                 125             
Asn Asn Gly Gly Gly Leu Gly Lys Lys Met Arg Ala Ile Ser Trp Thr
    130                 135                 140                 
Met Lys Lys Lys Val Gly Lys Lys Tyr Ile Lys Ala Leu Ser Glu Glu
145                 150                 155                 160 
Lys Asp Glu Glu Asp Gly Glu Asn Ala His Pro Tyr Arg Asn Ser Asp
                165                 170                 175     
Pro Val Ile Gly Thr His Thr Glu Lys Val Ser Leu Lys Ala Ser Asp
            180                 185                 190         
Ser Met Asp Ser Leu Tyr Ser Gly Gln Ser Ser Ser Ser Gly Ile Thr
        195                 200                 205             
Ser Cys Ser Asp Gly Thr Ser Asn Arg Asp Ser Phe Arg Leu Asp Asp
    210                 215                 220                 
Asp Gly Pro Tyr Ser Gly Pro Phe Cys Gly Arg Ala Arg Val His Thr
225                 230                 235                 240 
Asp Phe Thr Pro Ser Pro Tyr Asp Thr Asp Ser Leu Lys Ile Lys Lys
                245                 250                 255     
Gly Asp Ile Ile Asp Ile Ile Cys Lys Thr Pro Met Gly Met Trp Thr
            260                 265                 270         
Gly Met Leu Asn Asn Lys Val Gly Asn Phe Lys Phe Ile Tyr Val Asp
        275                 280                 285             
Val Ile Ser Glu Glu Glu Ala Ala Pro Lys Lys Ile Lys Ala Asn Arg
    290                 295                 300                 
Arg Ser Asn Ser Lys Lys Ser Lys Thr Leu Gln Glu Phe Leu Glu Arg
305                 310                 315                 320 
Ile His Leu Gln Glu Tyr Thr Ser Thr Leu Leu Leu Asn Gly Tyr Glu
                325                 330                 335     
Thr Leu Glu Asp Leu Lys Asp Ile Lys Glu Ser His Leu Ile Glu Leu
            340                 345                 350         
Asn Ile Glu Asn Pro Asp Asp Arg Arg Arg Leu Leu Ser Ala Ala Glu
        355                 360                 365             
Asn Phe Leu Glu Glu Glu Ile Ile Gln Glu Gln Glu Asn Glu Pro Glu
    370                 375                 380                 
Pro Leu Ser Leu Ser Ser Asp Ile Ser Leu Asn Lys Ser Gln Leu Asp
385                 390                 395                 400 
Asp Cys Pro Arg Asp Ser Gly Cys Tyr Ile Ser Ser Gly Asn Ser Asp
                405                 410                 415     
Asn Gly Lys Glu Asp Leu Glu Ser Glu Asn Leu Ser Asp Met Val His
            420                 425                 430         
Lys Ile Ile Ile Thr Glu Pro Ser Asp
        435                 440     


<210> 8573
<211> 373
<212> PRT
<213> Homo sapiens

<400> 8573
Met Leu Lys Arg Lys Pro Ser Asn Val Ser Glu Lys Glu Lys His Gln
 1               5                  10                  15      
Lys Pro Lys Arg Ser Ser Ser Phe Gly Asn Phe Asp Arg Phe Arg Asn
            20                  25                  30          
Asn Ser Leu Ser Lys Pro Asp Asp Ser Thr Glu Ala His Glu Gly Asp
        35                  40                  45              
Pro Thr Asn Gly Ser Gly Glu Gln Ser Lys Thr Ser Asn Asn Gly Gly
    50                  55                  60                  
Gly Leu Gly Lys Lys Met Arg Ala Ile Ser Trp Thr Met Lys Lys Lys
65                  70                  75                  80  
Val Gly Lys Lys Tyr Ile Lys Ala Leu Ser Glu Glu Lys Asp Glu Glu
                85                  90                  95      
Asp Gly Glu Asn Ala His Pro Tyr Arg Asn Ser Asp Pro Val Ile Gly
            100                 105                 110         
Thr His Thr Glu Lys Val Ser Leu Lys Ala Ser Asp Ser Met Asp Ser
        115                 120                 125             
Leu Tyr Ser Gly Gln Ser Ser Ser Ser Gly Ile Thr Ser Cys Ser Asp
    130                 135                 140                 
Gly Thr Ser Asn Arg Asp Ser Phe Arg Leu Asp Asp Asp Gly Pro Tyr
145                 150                 155                 160 
Ser Gly Pro Phe Cys Gly Arg Ala Arg Val His Thr Asp Phe Thr Pro
                165                 170                 175     
Ser Pro Tyr Asp Thr Asp Ser Leu Lys Ile Lys Lys Gly Asp Ile Ile
            180                 185                 190         
Asp Ile Ile Cys Lys Thr Pro Met Gly Met Trp Thr Gly Met Leu Asn
        195                 200                 205             
Asn Lys Val Gly Asn Phe Lys Phe Ile Tyr Val Asp Val Ile Ser Glu
    210                 215                 220                 
Glu Glu Ala Ala Pro Lys Lys Ile Lys Ala Asn Arg Arg Ser Asn Ser
225                 230                 235                 240 
Lys Lys Ser Lys Thr Leu Gln Glu Phe Leu Glu Arg Ile His Leu Gln
                245                 250                 255     
Glu Tyr Thr Ser Thr Leu Leu Leu Asn Gly Tyr Glu Thr Leu Glu Asp
            260                 265                 270         
Leu Lys Asp Ile Lys Glu Ser His Leu Ile Glu Leu Asn Ile Glu Asn
        275                 280                 285             
Pro Asp Asp Arg Arg Arg Leu Leu Ser Ala Ala Glu Asn Phe Leu Glu
    290                 295                 300                 
Glu Glu Ile Ile Gln Glu Gln Glu Asn Glu Pro Glu Pro Leu Ser Leu
305                 310                 315                 320 
Ser Ser Asp Ile Ser Leu Asn Lys Ser Gln Leu Asp Asp Cys Pro Arg
                325                 330                 335     
Asp Ser Gly Cys Tyr Ile Ser Ser Gly Asn Ser Asp Asn Gly Lys Glu
            340                 345                 350         
Asp Leu Glu Ser Glu Asn Leu Ser Asp Met Val His Lys Ile Ile Ile
        355                 360                 365             
Thr Glu Pro Ser Asp
    370             


<210> 8574
<211> 1544
<212> PRT
<213> Homo sapiens

<400> 8574
Met Ala Ala Pro Gln Asp Leu Asp Ile Ala Val Trp Leu Ala Thr Val
 1               5                  10                  15      
His Leu Glu Gln Tyr Ala Asp Thr Phe Arg Arg His Gly Leu Ala Thr
            20                  25                  30          
Ala Gly Ala Ala Arg Gly Leu Gly His Glu Glu Leu Lys Gln Leu Gly
        35                  40                  45              
Ile Ser Ala Thr Gly His Arg Lys Arg Ile Leu Arg Leu Leu Gln Thr
    50                  55                  60                  
Gly Thr Glu Glu Gly Ser Leu Asp Pro Lys Ser Asp Ser Ala Met Glu
65                  70                  75                  80  
Pro Ser Pro Ser Pro Ala Pro Gln Ala Gln Pro Pro Lys Pro Val Pro
                85                  90                  95      
Lys Pro Arg Thr Val Phe Gly Gly Leu Ser Gly Pro Ala Thr Thr Gln
            100                 105                 110         
Arg Pro Gly Leu Ser Pro Ala Leu Gly Gly Pro Gly Val Ser Arg Ser
        115                 120                 125             
Pro Glu Pro Ser Pro Arg Pro Pro Pro Leu Pro Thr Ser Ser Ser Glu
    130                 135                 140                 
Gln Ser Ser Ala Leu Asn Thr Val Glu Met Met Pro Asn Ser Ile Tyr
145                 150                 155                 160 
Phe Gly Leu Asp Ser Arg Gly Arg Ala Gln Ala Ala Gln Asp Lys Ala
                165                 170                 175     
Pro Asp Ser Ser Gln Ile Ser Ala Pro Thr Pro Ala Leu Arg Pro Thr
            180                 185                 190         
Thr Gly Thr Val His Ile Met Asp Pro Gly Cys Leu Tyr Tyr Gly Val
        195                 200                 205             
Gln Pro Val Gly Thr Pro Gly Ala Pro Asp Arg Arg Glu Ser Arg Gly
    210                 215                 220                 
Val Cys Gln Gly Arg Ala Glu His Arg Leu Ser Arg Gln Asp Leu Glu
225                 230                 235                 240 
Ala Arg Glu Asp Ala Gly Tyr Ala Ser Leu Glu Leu Pro Gly Asp Ser
                245                 250                 255     
Thr Leu Leu Ser Pro Thr Leu Glu Thr Glu Glu Thr Ser Asp Asp Leu
            260                 265                 270         
Ile Ser Pro Tyr Ala Ser Phe Ser Phe Thr Ala Asp Arg Leu Thr Pro
        275                 280                 285             
Leu Leu Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly Asn Tyr Val
    290                 295                 300                 
Phe Gln Arg Arg Phe Val Gln Phe Asn Gly Arg Ser Leu Met Tyr Phe
305                 310                 315                 320 
Gly Ser Asp Lys Asp Pro Phe Pro Lys Gly Val Ile Pro Leu Thr Ala
                325                 330                 335     
Ile Glu Met Thr Arg Ser Ser Lys Asp Asn Lys Phe Gln Val Ile Thr
            340                 345                 350         
Gly Gln Arg Val Phe Val Phe Arg Thr Glu Ser Glu Ala Gln Arg Asp
        355                 360                 365             
Met Trp Cys Ser Thr Leu Gln Ser Cys Leu Lys Glu Gln Arg Leu Leu
    370                 375                 380                 
Gly His Pro Arg Pro Pro Gln Pro Pro Arg Pro Leu Arg Thr Gly Met
385                 390                 395                 400 
Leu Glu Leu Arg Gly His Lys Ala Lys Val Phe Ala Ala Leu Ser Pro
                405                 410                 415     
Gly Glu Leu Ala Leu Tyr Lys Ser Glu Gln Ala Phe Ser Leu Gly Ile
            420                 425                 430         
Gly Ile Cys Phe Ile Glu Leu Gln Gly Cys Ser Val Arg Glu Thr Lys
        435                 440                 445             
Ser Arg Ser Phe Asp Leu Leu Thr Pro His Arg Cys Phe Ser Phe Thr
    450                 455                 460                 
Ala Glu Ser Gly Gly Ala Arg Gln Ser Trp Ala Ala Ala Leu Gln Glu
465                 470                 475                 480 
Ala Val Thr Glu Thr Leu Ser Asp Tyr Glu Val Ala Glu Lys Ile Trp
                485                 490                 495     
Ser Asn Arg Ala Asn Arg Gln Cys Ala Asp Cys Gly Ser Ser Arg Pro
            500                 505                 510         
Asp Trp Ala Ala Val Asn Leu Gly Val Val Ile Cys Lys Gln Cys Ala
        515                 520                 525             
Gly Gln His Arg Ala Leu Gly Ser Gly Ile Ser Lys Val Gln Ser Leu
    530                 535                 540                 
Lys Leu Asp Thr Ser Val Trp Ser Asn Glu Ile Val Gln Leu Phe Ile
545                 550                 555                 560 
Val Leu Gly Asn Asp Arg Ala Asn Arg Phe Trp Ala Gly Thr Leu Pro
                565                 570                 575     
Pro Gly Glu Gly Leu His Pro Asp Ala Thr Pro Gly Pro Arg Gly Glu
            580                 585                 590         
Phe Ile Ser Arg Lys Tyr Arg Leu Gly Leu Phe Arg Lys Pro His Pro
        595                 600                 605             
Gln Tyr Pro Asp His Ser Gln Leu Leu Gln Ala Leu Cys Ala Ala Val
    610                 615                 620                 
Ala Arg Pro Asn Leu Leu Lys Asn Met Thr Gln Leu Leu Cys Val Glu
625                 630                 635                 640 
Ala Phe Glu Gly Glu Glu Pro Trp Phe Pro Pro Ala Pro Asp Gly Ser
                645                 650                 655     
Cys Pro Gly Leu Leu Pro Ser Asp Pro Ser Pro Gly Val Tyr Asn Glu
            660                 665                 670         
Val Val Val Arg Ala Thr Tyr Ser Gly Phe Leu Tyr Cys Ser Pro Val
        675                 680                 685             
Ser Asn Lys Ala Gly Pro Ser Pro Pro Arg Arg Gly Arg Asp Ala Pro
    690                 695                 700                 
Pro Arg Leu Trp Cys Val Leu Gly Ala Ala Leu Glu Met Phe Ala Ser
705                 710                 715                 720 
Glu Asn Ser Pro Glu Pro Leu Ser Leu Ile Gln Pro Gln Asp Ile Val
                725                 730                 735     
Cys Leu Gly Val Ser Pro Pro Pro Thr Asp Pro Gly Asp Arg Phe Pro
            740                 745                 750         
Phe Ser Phe Glu Leu Ile Leu Ala Gly Gly Arg Ile Gln His Phe Gly
        755                 760                 765             
Thr Asp Gly Ala Asp Ser Leu Glu Ala Trp Thr Ser Ala Val Gly Lys
    770                 775                 780                 
Trp Phe Ser Pro Leu Ser Cys His Gln Leu Leu Gly Pro Gly Leu Leu
785                 790                 795                 800 
Arg Leu Gly Arg Leu Trp Leu Arg Ser Pro Ser His Thr Ala Pro Ala
                805                 810                 815     
Pro Gly Leu Trp Leu Ser Gly Phe Gly Leu Leu Arg Gly Asp His Leu
            820                 825                 830         
Phe Leu Cys Ser Ala Pro Gly Pro Gly Pro Pro Ala Pro Glu Asp Met
        835                 840                 845             
Val His Leu Arg Arg Leu Gln Glu Ile Ser Val Val Ser Ala Ala Asp
    850                 855                 860                 
Thr Pro Asp Lys Lys Glu His Leu Val Leu Val Glu Thr Gly Arg Thr
865                 870                 875                 880 
Leu Tyr Leu Gln Gly Glu Gly Arg Leu Asp Phe Thr Ala Trp Asn Ala
                885                 890                 895     
Ala Ile Gly Gly Ala Ala Gly Gly Gly Gly Thr Gly Leu Gln Glu Gln
            900                 905                 910         
Gln Met Ser Arg Gly Asp Ile Pro Ile Ile Val Asp Ala Cys Ile Ser
        915                 920                 925             
Phe Val Thr Gln His Gly Leu Arg Leu Glu Gly Val Tyr Arg Lys Gly
    930                 935                 940                 
Gly Ala Arg Ala Arg Ser Leu Arg Leu Leu Ala Glu Phe Arg Arg Asp
945                 950                 955                 960 
Ala Arg Ser Val Lys Leu Arg Pro Gly Glu His Phe Val Glu Asp Val
                965                 970                 975     
Thr Asp Thr Leu Lys Arg Phe Phe Arg Glu Leu Asp Asp Pro Val Thr
            980                 985                 990         
Ser Ala Arg Leu Leu Pro Arg Trp Arg Glu Ala Ala Glu Leu Pro Gln
        995                 1000                1005            
Lys Asn Gln Arg Leu Glu Lys Tyr Lys Asp Val Ile Gly Cys Leu Pro
    1010                1015                1020                
Arg Val Asn Arg Arg Thr Leu Ala Thr Leu Ile Gly His Leu Tyr Arg
1025                1030                1035                1040
Val Gln Lys Cys Ala Ala Leu Asn Gln Met Cys Thr Arg Asn Leu Ala
                1045                1050                1055    
Leu Leu Phe Ala Pro Ser Val Phe Gln Thr Asp Gly Arg Gly Glu His
            1060                1065                1070        
Glu Val Arg Val Leu Gln Glu Leu Ile Asp Gly Tyr Ile Ser Val Phe
        1075                1080                1085            
Asp Ile Asp Ser Asp Gln Val Ala Gln Ile Asp Leu Glu Val Ser Leu
    1090                1095                1100                
Ile Thr Thr Trp Lys Asp Val Gln Leu Ser Gln Ala Gly Asp Leu Ile
1105                1110                1115                1120
Met Glu Val Tyr Ile Glu Gln Gln Leu Pro Asp Asn Cys Val Thr Leu
                1125                1130                1135    
Lys Val Ser Pro Thr Leu Thr Ala Glu Glu Leu Thr Asn Gln Val Leu
            1140                1145                1150        
Glu Met Arg Gly Thr Ala Ala Gly Met Asp Leu Trp Val Thr Phe Glu
        1155                1160                1165            
Ile Arg Glu His Gly Glu Leu Glu Arg Pro Leu His Pro Lys Glu Lys
    1170                1175                1180                
Val Leu Glu Gln Ala Leu Gln Trp Cys Gln Leu Pro Glu Pro Cys Ser
1185                1190                1195                1200
Ala Ser Leu Leu Leu Lys Lys Val Pro Leu Ala Gln Ala Gly Cys Leu
                1205                1210                1215    
Phe Thr Gly Ile Arg Arg Glu Ser Pro Arg Val Gly Leu Leu Arg Cys
            1220                1225                1230        
Arg Glu Glu Pro Pro Arg Leu Leu Gly Ser Arg Phe Gln Glu Arg Phe
        1235                1240                1245            
Phe Leu Leu Arg Gly Arg Cys Leu Leu Leu Leu Lys Glu Lys Lys Ser
    1250                1255                1260                
Ser Lys Pro Glu Arg Glu Trp Pro Leu Glu Gly Ala Lys Val Tyr Leu
1265                1270                1275                1280
Gly Ile Arg Lys Lys Leu Lys Pro Pro Thr Pro Trp Gly Phe Thr Leu
                1285                1290                1295    
Ile Leu Glu Lys Met His Leu Tyr Leu Ser Cys Thr Asp Glu Asp Glu
            1300                1305                1310        
Met Trp Asp Trp Thr Thr Ser Ile Leu Lys Ala Gln His Asp Asp Gln
        1315                1320                1325            
Gln Pro Val Val Leu Arg Arg His Ser Ser Ser Asp Leu Ala Arg Gln
    1330                1335                1340                
Lys Phe Gly Thr Met Pro Leu Leu Pro Ile Arg Gly Asp Asp Ser Gly
1345                1350                1355                1360
Ala Thr Leu Leu Ser Ala Asn Gln Thr Leu Arg Arg Leu His Asn Arg
                1365                1370                1375    
Arg Thr Leu Ser Met Phe Phe Pro Met Lys Ser Ser Gln Gly Ser Val
            1380                1385                1390        
Glu Glu Gln Glu Glu Leu Glu Glu Pro Val Tyr Glu Glu Pro Val Tyr
        1395                1400                1405            
Glu Glu Val Gly Ala Phe Pro Glu Leu Ile Gln Asp Thr Ser Thr Ser
    1410                1415                1420                
Phe Ser Thr Thr Arg Glu Trp Thr Val Lys Pro Glu Asn Pro Leu Thr
1425                1430                1435                1440
Ser Gln Lys Ser Leu Asp Gln Pro Phe Leu Ser Lys Ser Ser Thr Leu
                1445                1450                1455    
Gly Gln Glu Glu Arg Pro Pro Glu Pro Pro Pro Gly Pro Pro Ser Lys
            1460                1465                1470        
Ser Ser Pro Gln Ala Arg Gly Ser Leu Glu Glu Gln Leu Leu Gln Glu
        1475                1480                1485            
Leu Ser Ser Leu Ile Leu Arg Lys Gly Glu Thr Thr Ala Gly Leu Gly
    1490                1495                1500                
Ser Pro Ser Gln Pro Ser Ser Pro Gln Ser Pro Ser Pro Thr Gly Leu
1505                1510                1515                1520
Pro Thr Gln Thr Pro Gly Phe Pro Thr Gln Pro Pro Cys Thr Ser Ser
                1525                1530                1535    
Pro Pro Ser Ser Gln Pro Leu Thr
            1540                


<210> 8575
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8575
Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu
 1               5                  10                  15      
Asp Ala Ser Ser Asn Val Asp Lys Met Met Val Leu Asn Ser Ala Leu
            20                  25                  30          
Thr Glu Val Ser Glu Asp Ser Thr Thr Gly Glu Asp Val Leu Leu Ser
        35                  40                  45              
Glu Gly Ser Val Gly Lys Asn Lys Ser Ser Ala Cys Arg Arg Lys Arg
    50                  55                  60                  
Glu Phe Ile Pro Asp Glu Lys Lys Asp Ala Met Tyr Trp Glu Lys Arg
65                  70                  75                  80  
Arg Lys Asn Asn Glu Ala Ala Lys Arg Ser Arg Glu Lys Arg Arg Leu
                85                  90                  95      
Asn Asp Leu Val Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn
            100                 105                 110         
Ala Thr Leu Lys Ala Glu Leu Leu Ser Leu Lys Leu Lys Phe Gly Leu
        115                 120                 125             
Ile Ser Ser Thr Ala Tyr Ala Gln Glu Ile Gln Lys Leu Ser Asn Ser
    130                 135                 140                 
Thr Ala Val Tyr Phe Gln Asp Tyr Gln Thr Ser Lys Ser Asn Val Ser
145                 150                 155                 160 
Ser Phe Val Asp Glu His Glu Pro Ser Met Val Ser Ser Ser Cys Ile
                165                 170                 175     
Ser Val Ile Lys His Ser Pro Gln Ser Ser Leu Ser Asp Val Ser Glu
            180                 185                 190         
Val Ser Ser Val Glu His Thr Gln Glu Ser Ser Val Gln Gly Ser Cys
        195                 200                 205             
Arg Ser Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu
    210                 215                 220                 
Leu Glu Ser Tyr Thr Arg Glu Pro Arg Asp Asp Arg Gly Ser Tyr Thr
225                 230                 235                 240 
Ala Ser Ile Tyr Gln Asn Tyr Met Gly Asn Ser Phe Ser Gly Tyr Ser
                245                 250                 255     
His Ser Pro Pro Leu Leu Gln Val Asn Arg Ser Ser Ser Asn Ser Pro
            260                 265                 270         
Arg Thr Ser Glu Thr Asp Asp Gly Val Val Gly Lys Ser Ser Asp Gly
        275                 280                 285             
Glu Asp Glu Gln Gln Val Pro Lys Gly Pro Ile His Ser Pro Val Glu
    290                 295                 300                 
Leu Lys His Val His Ala Thr Val Val Lys Val Pro Glu Val Asn Ser
305                 310                 315                 320 
Ser Ala Leu Pro His Lys Leu Arg Ile Lys Ala Lys Ala Met Gln Ile
                325                 330                 335     
Lys Val Glu Ala Phe Asp Asn Glu Phe Glu Ala Thr Gln Lys Leu Ser
            340                 345                 350         
Ser Pro Ile Asp Met Thr Ser Lys Arg His Phe Glu Leu Glu Lys His
        355                 360                 365             
Ser Ala Pro Ser Met Val His Ser Ser Leu Thr Pro Phe Ser Val Gln
    370                 375                 380                 
Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln
385                 390                 395                 400 
Lys Glu Leu Ser Gly Lys Thr Gln Asn Ser Phe Lys Thr Gly Val Val
                405                 410                 415     
Glu Met Lys Asp Ser Gly Tyr Lys Val Ser Asp Pro Glu Asn Leu Tyr
            420                 425                 430         
Leu Lys Gln Gly Ile Ala Asn Leu Ser Ala Glu Val Val Ser Leu Lys
        435                 440                 445             
Arg Leu Ile Ala Thr Gln Pro Ile Ser Ala Ser Asp Ser Gly
    450                 455                 460         


<210> 8576
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8576
Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu
 1               5                  10                  15      
Asp Ala Ser Ser Asn Val Asp Lys Met Met Val Leu Asn Ser Ala Leu
            20                  25                  30          
Thr Glu Val Ser Glu Asp Ser Thr Thr Gly Glu Asp Val Leu Leu Ser
        35                  40                  45              
Glu Gly Ser Val Gly Lys Asn Lys Ser Ser Ala Cys Arg Arg Lys Arg
    50                  55                  60                  
Glu Phe Ile Pro Asp Glu Lys Lys Asp Ala Met Tyr Trp Glu Lys Arg
65                  70                  75                  80  
Arg Lys Asn Asn Glu Ala Ala Lys Arg Ser Arg Glu Lys Arg Arg Leu
                85                  90                  95      
Asn Asp Leu Val Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn
            100                 105                 110         
Ala Thr Leu Lys Ala Glu Leu Leu Ser Leu Lys Leu Lys Phe Gly Leu
        115                 120                 125             
Ile Ser Ser Thr Ala Tyr Ala Gln Glu Ile Gln Lys Leu Ser Asn Ser
    130                 135                 140                 
Thr Ala Val Tyr Phe Gln Asp Tyr Gln Thr Ser Lys Ser Asn Val Ser
145                 150                 155                 160 
Ser Phe Val Asp Glu His Glu Pro Ser Met Val Ser Ser Ser Cys Ile
                165                 170                 175     
Ser Val Ile Lys His Ser Pro Gln Ser Ser Leu Ser Asp Val Ser Glu
            180                 185                 190         
Val Ser Ser Val Glu His Thr Gln Glu Ser Ser Val Gln Gly Ser Cys
        195                 200                 205             
Arg Ser Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu
    210                 215                 220                 
Leu Glu Ser Tyr Thr Arg Glu Pro Arg Asp Asp Arg Gly Ser Tyr Thr
225                 230                 235                 240 
Ala Ser Ile Tyr Gln Asn Tyr Met Gly Asn Ser Phe Ser Gly Tyr Ser
                245                 250                 255     
His Ser Pro Pro Leu Leu Gln Val Asn Arg Ser Ser Ser Asn Ser Pro
            260                 265                 270         
Gly Thr Ser Glu Thr Asp Asp Gly Val Val Gly Lys Ser Ser Asp Gly
        275                 280                 285             
Glu Asp Glu Gln Gln Val Pro Lys Gly Pro Ile His Ser Pro Val Glu
    290                 295                 300                 
Leu Lys His Val His Ala Thr Val Val Lys Val Pro Glu Val Asn Ser
305                 310                 315                 320 
Ser Ala Leu Pro His Lys Leu Arg Ile Lys Ala Lys Ala Met Gln Ile
                325                 330                 335     
Lys Val Glu Ala Phe Asp Asn Glu Phe Glu Ala Thr Gln Lys Leu Ser
            340                 345                 350         
Ser Pro Ile Asp Met Thr Ser Lys Arg His Phe Glu Leu Glu Lys His
        355                 360                 365             
Ser Ala Pro Ser Met Val His Ser Ser Leu Thr Pro Phe Ser Val Gln
    370                 375                 380                 
Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln
385                 390                 395                 400 
Lys Glu Leu Ser Gly Lys Thr Gln Asn Ser Phe Lys Thr Gly Val Val
                405                 410                 415     
Glu Met Lys Asp Ser Gly Tyr Lys Val Ser Asp Pro Glu Asn Leu Tyr
            420                 425                 430         
Leu Lys Gln Gly Ile Ala Asn Leu Ser Ala Glu Val Val Ser Leu Lys
        435                 440                 445             
Arg Leu Ile Ala Thr Gln Pro Ile Ser Ala Ser Asp Ser Gly
    450                 455                 460         


<210> 8577
<211> 483
<212> PRT
<213> Homo sapiens

<400> 8577
Met Val Ala Arg Ser Glu Ser Val Leu Leu His Met Pro Gln Pro Val
 1               5                  10                  15      
Asn Pro Glu Leu Thr Ile Gly Pro Ile Thr Gly Pro Val Asp Arg Leu
            20                  25                  30          
Asn His Phe Arg Val Glu Thr Ser Phe Thr Trp Glu Val Thr Asn Tyr
        35                  40                  45              
Asn Ile Arg Leu Phe Glu Asp Val Arg Ser Leu Met Phe Arg Cys Gly
    50                  55                  60                  
Ser Leu Asn Ser Asp Arg Ser Asp Asn Phe Ala Ala Trp Gly Ala Trp
65                  70                  75                  80  
Val Phe Ser Ser Gly Lys His Tyr Trp Glu Leu Asp Val Asp Asn Ser
                85                  90                  95      
Trp Asp Trp Ala Leu Gly Val Tyr Ile Leu Arg Leu Leu Glu Cys Met
            100                 105                 110         
Glu Asn Asn Leu Pro Ser Asp Asp Asn Ser Thr Phe Asn Ser Thr Gln
        115                 120                 125             
Ser His Met Asp Trp Gly Lys Val Ala Phe Lys Asn Phe Ser Gly Glu
    130                 135                 140                 
Met Tyr Arg Leu Arg Trp Leu Glu Ile Ser Cys Asn Leu Arg Lys Phe
145                 150                 155                 160 
Gly Thr Leu Lys Glu Leu Val Leu Glu Ala Lys Lys Cys Val Lys Lys
                165                 170                 175     
Met Asn Lys Ser Gln Lys Ser Arg Asn Arg Pro Asp Phe Pro Lys Arg
            180                 185                 190         
Pro Leu Thr Ala Tyr Asn Arg Phe Phe Val Glu Ser Trp Leu Gln Tyr
        195                 200                 205             
Ser Gln Met Tyr Pro Gly Met Arg Ser Gln Glu Leu Thr Lys Ile Leu
    210                 215                 220                 
Ser Lys Lys Tyr Lys Glu Leu Pro Glu Gln Met Lys Gln Lys Tyr Ile
225                 230                 235                 240 
Gln Asp Phe Gln Lys Ala Lys Gln Glu Phe Glu Glu Lys Leu Ala Arg
                245                 250                 255     
Phe Ser Glu Glu His Pro Asp Leu Val Gln Lys Ala Lys Lys Ser Gly
            260                 265                 270         
Val Ser Lys Arg Thr Gln Asn Lys Val Gln Lys Lys Val Gln Lys Asn
        275                 280                 285             
Ile Glu Glu Val Arg Ser Leu Pro Lys Thr Asp Arg Phe Phe Lys Lys
    290                 295                 300                 
Val Lys Phe His Gly Glu Pro Gln Lys Pro Pro Met Asn Gly Tyr His
305                 310                 315                 320 
Lys Phe His Gln Asp Ser Trp Ser Ser Lys Glu Leu Gln His Leu Ser
                325                 330                 335     
Val Arg Glu Arg Met Val Glu Ile Gly Arg Arg Trp Gln Arg Ile Pro
            340                 345                 350         
Gln Ser Gln Lys Asp His Phe Lys Ser Gln Ala Glu Glu Leu Gln Lys
        355                 360                 365             
Gln Tyr Lys Val Lys Leu Asp Leu Trp Leu Lys Thr Leu Ser Pro Glu
    370                 375                 380                 
Asn Tyr Ala Ala Tyr Lys Glu Ser Thr Tyr Ala Lys Gly Lys Asn Met
385                 390                 395                 400 
Ala Met Thr Gly Gly Pro Asp Pro Arg Leu Lys Gln Ala Asp Pro Gln
                405                 410                 415     
Ser Ser Ser Thr Lys Gly Leu Gln Glu Gly Phe Gly Glu Gly Gln Gly
            420                 425                 430         
Leu Gln Ala Ala Gly Thr Asp Ser Ser Gln Thr Ile Trp Val Asn Cys
        435                 440                 445             
His Val Ser Met Glu Pro Glu Glu Asn Arg Lys Lys Asp Gly Glu Glu
    450                 455                 460                 
Glu Glu Ser Ser Asn Ser Ser Asp Cys Ser Ser Gly Glu Glu Met Glu
465                 470                 475                 480 
Val Asp Val
            


<210> 8578
<211> 521
<212> PRT
<213> Homo sapiens

<400> 8578
Met Ala Asn Lys Gly Lys Lys Lys Arg Arg Gln Phe Ser Leu Glu Glu
 1               5                  10                  15      
Lys Met Lys Val Val Gly Ala Val Asp Ser Gly Lys Arg Lys Gly Asp
            20                  25                  30          
Val Ala Lys Glu Phe Gly Ile Thr Pro Ser Thr Leu Ser Thr Phe Leu
        35                  40                  45              
Lys Asp Arg Thr Lys Phe Glu Glu Lys Val Arg Glu Ala Ser Val Gly
    50                  55                  60                  
Pro Gln Arg Lys Arg Met Arg Ser Ala Leu Tyr Asp Asp Ile Asp Lys
65                  70                  75                  80  
Ala Val Phe Ala Trp Phe Gln Glu Ile His Ala Lys Asn Ile Leu Val
                85                  90                  95      
Thr Gly Ser Val Ile Arg Lys Lys Ala Leu Asn Leu Ala Asn Met Leu
            100                 105                 110         
Gly Tyr Asp Asn Phe Gln Ala Ser Val Gly Trp Leu Asn Arg Phe Arg
        115                 120                 125             
Asp Arg His Gly Ile Ala Leu Lys Ala Val Cys Arg Glu Asp Ser Asp
    130                 135                 140                 
Arg Leu Met Asn Gly Leu Gly Ile Asp Lys Ile Asn Glu Trp His Ala
145                 150                 155                 160 
Gly Glu Ile Ile Lys Leu Ile Ala Asp Tyr Ser Pro Asp Asp Ile Phe
                165                 170                 175     
Asn Ala Asp Glu Thr Gly Val Phe Phe Gln Leu Leu Pro Gln His Thr
            180                 185                 190         
Leu Ala Ala Lys Gly Asp His Cys Arg Gly Gly Lys Lys Ala Lys Gln
        195                 200                 205             
Arg Leu Thr Ala Leu Phe Cys Cys Asn Ala Ser Gly Thr Glu Lys Met
    210                 215                 220                 
Arg Pro Leu Ile Val Gly Arg Ser Ala Ser Pro His Cys Leu Lys Asn
225                 230                 235                 240 
Ile His Ser Leu Pro Cys Asp Tyr Arg Ala Asn Gln Trp Ala Trp Met
                245                 250                 255     
Thr Arg Asp Leu Phe Asn Glu Trp Leu Met Gln Val Asp Ala Arg Met
            260                 265                 270         
Lys Arg Ala Glu Arg Arg Ile Leu Leu Leu Ile Asp Asn Cys Ser Ala
        275                 280                 285             
His Asn Met Leu Pro His Leu Glu Arg Ile Gln Val Gly Tyr Leu Pro
    290                 295                 300                 
Ser Asn Cys Thr Ala Val Leu Gln Pro Leu Asn Leu Gly Ile Ile His
305                 310                 315                 320 
Thr Met Lys Val Leu Tyr Gln Ser His Leu Leu Lys Gln Ile Leu Leu
                325                 330                 335     
Lys Leu Asn Ser Ser Glu Asp Gln Glu Glu Val Asp Ile Lys Gln Ala
            340                 345                 350         
Ile Asp Met Ile Ala Ala Ala Trp Trp Ser Val Lys Pro Ser Thr Val
        355                 360                 365             
Val Lys Cys Trp Gln Lys Ala Gly Ile Val Pro Met Glu Phe Ala Glu
    370                 375                 380                 
Cys Asp Thr Glu Ser Ala Ala Ser Glu Pro Asp Ile Ala Ile Glu Lys
385                 390                 395                 400 
Leu Trp His Thr Val Ala Ile Ala Thr Cys Val Pro Asn Glu Val Asn
                405                 410                 415     
Phe Gln Asp Phe Val Thr Ala Asp Asp Asp Leu Ile Ile Ser Gln Asp
            420                 425                 430         
Thr Asp Ile Ile Gln Asp Met Val Ala Gly Glu Asn Thr Ser Glu Ala
        435                 440                 445             
Gly Ser Glu Asp Glu Gly Glu Val Ser Leu Pro Glu Gln Pro Lys Val
    450                 455                 460                 
Thr Ile Thr Glu Ala Ile Ser Ser Val Gln Lys Leu Arg Gln Phe Leu
465                 470                 475                 480 
Ser Thr Cys Val Asp Ile Pro Asp Ala Ile Phe Gly Gln Leu Asn Gly
                485                 490                 495     
Ile Asp Glu Tyr Leu Met Lys Arg Val Thr Gln Thr Leu Ile Asp Ser
            500                 505                 510         
Lys Ile Thr Asp Phe Leu Gln Thr Lys
        515                 520     


<210> 8579
<211> 521
<212> PRT
<213> Homo sapiens

<400> 8579
Met Ala Asn Lys Gly Asn Lys Lys Arg Arg Gln Phe Ser Leu Glu Glu
 1               5                  10                  15      
Lys Met Lys Val Val Gly Ala Val Asp Ser Gly Lys Arg Lys Gly Asp
            20                  25                  30          
Val Ala Lys Glu Phe Gly Ile Thr Pro Ser Thr Leu Ser Thr Phe Leu
        35                  40                  45              
Lys Asp Arg Thr Lys Phe Glu Glu Lys Val Arg Glu Ala Ser Val Gly
    50                  55                  60                  
Pro Gln Arg Lys Arg Met Arg Ser Ala Leu Tyr Asp Asp Ile Asp Lys
65                  70                  75                  80  
Ala Val Phe Ala Trp Phe Gln Glu Ile His Ala Lys Asn Ile Leu Val
                85                  90                  95      
Thr Gly Ser Val Ile Arg Lys Lys Ala Leu Asn Leu Ala Asn Met Leu
            100                 105                 110         
Gly Tyr Asp Asn Phe Gln Ala Ser Val Gly Trp Leu Asn Arg Phe Arg
        115                 120                 125             
Asp Arg His Gly Ile Ala Leu Lys Ala Val Cys Arg Glu Asp Ser Asp
    130                 135                 140                 
Arg Leu Met Asn Gly Leu Gly Ile Asp Lys Ile Asn Glu Trp His Ala
145                 150                 155                 160 
Gly Glu Ile Ile Lys Leu Ile Ala Asp Tyr Ser Pro Asp Asp Ile Phe
                165                 170                 175     
Asn Ala Asp Glu Thr Gly Val Phe Phe Gln Leu Leu Pro Gln His Thr
            180                 185                 190         
Leu Ala Ala Lys Gly Asp His Cys Arg Gly Gly Lys Lys Ala Lys Gln
        195                 200                 205             
Arg Leu Thr Ala Leu Phe Cys Cys Asn Ala Ser Gly Thr Glu Lys Met
    210                 215                 220                 
Arg Pro Leu Ile Val Gly Arg Ser Ala Ser Pro His Cys Leu Lys Asn
225                 230                 235                 240 
Ile His Ser Leu Pro Cys Asp Tyr Arg Ala Asn Gln Trp Ala Trp Met
                245                 250                 255     
Thr Arg Asp Leu Phe Asn Glu Trp Leu Met Gln Val Asp Ala Arg Met
            260                 265                 270         
Lys Arg Ala Glu Arg Arg Ile Leu Leu Leu Ile Asp Asn Cys Ser Ala
        275                 280                 285             
His Asn Met Leu Pro His Leu Glu Arg Ile Gln Val Gly Tyr Leu Pro
    290                 295                 300                 
Ser Asn Cys Thr Ala Val Leu Gln Pro Leu Asn Leu Gly Ile Ile His
305                 310                 315                 320 
Thr Met Lys Val Leu Tyr Gln Ser His Leu Leu Lys Gln Ile Leu Leu
                325                 330                 335     
Lys Leu Asn Ser Ser Glu Asp Gln Glu Glu Val Asp Ile Lys Gln Ala
            340                 345                 350         
Ile Asp Met Ile Ala Ala Ala Trp Trp Ser Val Lys Pro Ser Thr Val
        355                 360                 365             
Val Lys Cys Trp Gln Lys Ala Gly Ile Val Pro Met Glu Phe Ala Glu
    370                 375                 380                 
Cys Asp Thr Glu Ser Ala Ala Ser Glu Pro Asp Ile Ala Ile Glu Lys
385                 390                 395                 400 
Leu Trp His Thr Val Ala Ile Ala Thr Cys Val Pro Asn Glu Val Asn
                405                 410                 415     
Phe Gln Asp Phe Val Thr Ala Asp Asp Asp Leu Ile Ile Ser Gln Asp
            420                 425                 430         
Thr Asp Ile Ile Gln Asp Met Val Ala Gly Glu Asn Thr Ser Glu Ala
        435                 440                 445             
Gly Ser Glu Asp Glu Gly Glu Val Ser Leu Pro Glu Gln Pro Lys Val
    450                 455                 460                 
Thr Ile Thr Glu Ala Ile Ser Ser Val Gln Lys Leu Arg Gln Phe Leu
465                 470                 475                 480 
Ser Thr Cys Val Asp Ile Pro Asp Ala Ile Phe Gly Gln Leu Asn Gly
                485                 490                 495     
Ile Asp Glu Tyr Leu Met Lys Arg Val Thr Gln Thr Leu Ile Asp Ser
            500                 505                 510         
Lys Ile Thr Asp Phe Leu Gln Thr Lys
        515                 520     


<210> 8580
<211> 330
<212> PRT
<213> Homo sapiens

<400> 8580
Met Ala Thr Lys Glu Ser Arg Asp Ala Lys Ala Gln Leu Ala Leu Ser
 1               5                  10                  15      
Ser Ser Ala Asn Gln Ser Lys Glu Val Pro Glu Asn Pro Asn Tyr Ala
            20                  25                  30          
Leu Lys Cys Thr Leu Val Gly His Thr Glu Ala Val Ser Ser Val Lys
        35                  40                  45              
Phe Ser Pro Asn Gly Glu Trp Leu Ala Ser Ser Ser Ala Asp Arg Leu
    50                  55                  60                  
Ile Ile Ile Trp Gly Ala Tyr Asp Gly Lys Tyr Glu Lys Thr Leu Tyr
65                  70                  75                  80  
Gly His Asn Leu Glu Ile Ser Asp Val Ala Trp Ser Ser Asp Ser Ser
                85                  90                  95      
Arg Leu Val Ser Ala Ser Asp Asp Lys Thr Leu Lys Leu Trp Asp Val
            100                 105                 110         
Arg Ser Gly Lys Cys Leu Lys Thr Leu Lys Gly His Ser Asn Tyr Val
        115                 120                 125             
Phe Cys Cys Asn Phe Asn Pro Pro Ser Asn Leu Ile Ile Ser Gly Ser
    130                 135                 140                 
Phe Asp Glu Thr Val Lys Ile Trp Glu Val Lys Thr Gly Lys Cys Leu
145                 150                 155                 160 
Lys Thr Leu Ser Ala His Ser Asp Pro Val Ser Ala Val His Phe Asn
                165                 170                 175     
Cys Ser Gly Ser Leu Ile Val Ser Gly Ser Tyr Asp Gly Leu Cys Arg
            180                 185                 190         
Ile Trp Asp Ala Ala Ser Gly Gln Cys Leu Lys Thr Leu Val Asp Asp
        195                 200                 205             
Asp Asn Pro Pro Val Ser Phe Val Lys Phe Ser Pro Asn Gly Lys Tyr
    210                 215                 220                 
Ile Leu Thr Ala Thr Leu Asp Asn Thr Leu Lys Leu Trp Asp Tyr Ser
225                 230                 235                 240 
Arg Gly Arg Cys Leu Lys Thr Tyr Thr Gly His Lys Asn Glu Lys Tyr
                245                 250                 255     
Cys Ile Phe Ala Asn Phe Ser Val Thr Gly Gly Lys Trp Ile Val Ser
            260                 265                 270         
Gly Ser Glu Asp Asn Leu Val Tyr Ile Trp Asn Leu Gln Thr Lys Glu
        275                 280                 285             
Ile Val Gln Lys Leu Gln Gly His Thr Asp Val Val Ile Ser Ala Ala
    290                 295                 300                 
Cys His Pro Thr Glu Asn Leu Ile Ala Ser Ala Ala Leu Glu Asn Asp
305                 310                 315                 320 
Lys Thr Ile Lys Leu Trp Met Ser Asn His
                325                 330 


<210> 8581
<211> 131
<212> PRT
<213> Homo sapiens

<400> 8581
Met Phe Ser Asp Asn Ser His Cys Pro Asp Cys Gly Gln Gln Trp Phe
 1               5                  10                  15      
Pro Ser Leu Glu Leu Gly His Trp Leu Tyr Gln Thr Glu Leu Val Glu
            20                  25                  30          
Asn Glu Cys Tyr Gln Val Phe Leu Asp Arg Ile Asn Arg Ala Asp Tyr
        35                  40                  45              
Cys Pro Glu Cys Tyr Pro Asp Asn Pro Ala Asn Arg Ser Leu Val Leu
    50                  55                  60                  
Pro Trp Ser Phe Pro Leu Glu Trp Ala Pro Gln Asn Leu Thr Arg Trp
65                  70                  75                  80  
Thr Phe Glu Lys Ala Cys His Pro Phe Leu Leu Gly Pro Pro Leu Val
                85                  90                  95      
Arg Lys Arg Ile His Asp Ser Arg Val Ala Gly Phe Asn Pro Ala Leu
            100                 105                 110         
Gln Leu Ile Leu Thr Arg Thr Asp Lys Thr Leu Asn Lys Lys Leu Gly
        115                 120                 125             
Gln Asn Lys
    130     


<210> 8582
<211> 636
<212> PRT
<213> Homo sapiens

<400> 8582
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu
 1               5                  10                  15      
Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly
            20                  25                  30          
Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe
        35                  40                  45              
Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile
    50                  55                  60                  
Met Thr Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Thr Tyr
65                  70                  75                  80  
Leu Leu Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Val
                85                  90                  95      
Glu Asp Gly Glu His Gln Val Lys Met Lys Ala Phe Arg Glu Ala His
            100                 105                 110         
Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu
        115                 120                 125             
Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu
    130                 135                 140                 
Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu
145                 150                 155                 160 
Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe
                165                 170                 175     
Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly
            180                 185                 190         
Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser
        195                 200                 205             
Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly
    210                 215                 220                 
Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys
225                 230                 235                 240 
Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp
                245                 250                 255     
Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Thr
            260                 265                 270         
Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser
        275                 280                 285             
Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys
    290                 295                 300                 
Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu
305                 310                 315                 320 
Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser
                325                 330                 335     
Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu
            340                 345                 350         
Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro
        355                 360                 365             
Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val
    370                 375                 380                 
Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu
385                 390                 395                 400 
Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu
                405                 410                 415     
Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr
            420                 425                 430         
Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys
        435                 440                 445             
Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr
    450                 455                 460                 
Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu
465                 470                 475                 480 
Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg
                485                 490                 495     
Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly
            500                 505                 510         
Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln
        515                 520                 525             
Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu
    530                 535                 540                 
Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu
545                 550                 555                 560 
Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg
                565                 570                 575     
Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu Leu Ser
            580                 585                 590         
Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr
        595                 600                 605             
Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly
    610                 615                 620                 
Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu
625                 630                 635     


<210> 8583
<211> 622
<212> PRT
<213> Homo sapiens

<400> 8583
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu
 1               5                  10                  15      
Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly
            20                  25                  30          
Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe
        35                  40                  45              
Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile
    50                  55                  60                  
Met Thr Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Thr Tyr
65                  70                  75                  80  
Leu Leu Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Glu
                85                  90                  95      
Ala His Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu
            100                 105                 110         
Ile Glu Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg
        115                 120                 125             
Lys Leu Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg
    130                 135                 140                 
Ser Leu Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro
145                 150                 155                 160 
Ser Phe Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala
                165                 170                 175     
Glu Gly Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe
            180                 185                 190         
Val Ser Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu
        195                 200                 205             
Thr Gly Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys
    210                 215                 220                 
Val Lys Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu
225                 230                 235                 240 
Ile Asp Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly
                245                 250                 255     
Arg Thr Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile
            260                 265                 270         
Lys Ser Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn
        275                 280                 285             
Ser Lys Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly
    290                 295                 300                 
Tyr Leu Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg
305                 310                 315                 320 
Asn Ser Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly
                325                 330                 335     
Arg Leu Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val
            340                 345                 350         
Lys Pro Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val
        355                 360                 365             
Tyr Val Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu
    370                 375                 380                 
Leu Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn
385                 390                 395                 400 
Asn Leu Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile
                405                 410                 415     
Leu Thr Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr
            420                 425                 430         
Leu Lys Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu
        435                 440                 445             
Glu Tyr Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro
    450                 455                 460                 
Gly Glu Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser
465                 470                 475                 480 
Ser Arg Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val
                485                 490                 495     
Leu Gly Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp
            500                 505                 510         
Leu Gln Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr
        515                 520                 525             
Gly Leu Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn
    530                 535                 540                 
Lys Glu Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala
545                 550                 555                 560 
Thr Arg Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu
                565                 570                 575     
Leu Ser Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp
            580                 585                 590         
Asp Thr Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly
        595                 600                 605             
Leu Gly Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu
    610                 615                 620         


<210> 8584
<211> 599
<212> PRT
<213> Homo sapiens

<400> 8584
Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Glu Val Ala Gly Gly
 1               5                  10                  15      
Glu Ala Thr Ala Pro Gly Lys Val Leu Arg Glu Glu Asn Gln Cys Ile
            20                  25                  30          
Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly Thr Arg Pro Thr Ala
        35                  40                  45              
Met Gly Ser Phe Ser Ser His Met Thr Glu Phe Pro Arg Lys Arg Lys
    50                  55                  60                  
Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His Ser Gln Thr Glu Lys
65                  70                  75                  80  
Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu Ser Ala Met
                85                  90                  95      
Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys Leu Thr Val
            100                 105                 110         
Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly Leu Thr Asn
        115                 120                 125             
Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln Asp Asn Glu
    130                 135                 140                 
Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly Phe Leu Phe Val Val
145                 150                 155                 160 
Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser Val Ser Lys
                165                 170                 175     
Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly Gln Ser Leu Phe Asp
            180                 185                 190         
Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln Leu Ser Ser
        195                 200                 205             
Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys Thr Gly Leu
    210                 215                 220                 
Gln Val His Ser Asn Leu His Ala Gly Arg Thr Arg Val Tyr Ser Gly
225                 230                 235                 240 
Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys Ile Ser Val
                245                 250                 255     
Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys Glu His Arg
            260                 265                 270         
Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu Arg Ser Trp Pro Pro
        275                 280                 285             
Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys Asp Asn Ser
    290                 295                 300                 
Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu Gln Pro Tyr Ile Val
305                 310                 315                 320 
Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Thr Glu Phe Ile Thr
                325                 330                 335     
Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln Arg Ala Thr
            340                 345                 350         
Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Thr Ser Cys Tyr
        355                 360                 365             
Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Thr Asp Lys His Lys
    370                 375                 380                 
Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr Asp Ser Tyr Lys Phe
385                 390                 395                 400 
Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys Ser Gln Trp Phe Ser
                405                 410                 415     
Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr Ile Val Ser Val Asn
            420                 425                 430         
Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser Phe Leu Pro
        435                 440                 445             
Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser Cys Met Ser
    450                 455                 460                 
Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly Ala Gly Ser Ile Gly
465                 470                 475                 480 
Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu Gln Ser Ser
                485                 490                 495     
Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu Met Lys Asp Thr His
            500                 505                 510         
Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu Leu Phe Pro Pro Ser
        515                 520                 525             
Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg Gln Asn Gln Ser Thr
    530                 535                 540                 
Val Ala Val His Ser His Glu Pro Leu Leu Ser Asp Gly Ala Gln Leu
545                 550                 555                 560 
Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr Ala Met Ala Ala Phe
                565                 570                 575     
Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly Asp Pro Gly Asp Phe
            580                 585                 590         
Ser Asp Ile Gln Trp Thr Leu
        595                 


<210> 8585
<211> 726
<212> PRT
<213> Homo sapiens

<400> 8585
Thr Ala Cys Pro Cys Val Leu Gln Pro Ser Ala Gly Pro Ala Glu Gln
 1               5                  10                  15      
Gln Gln Arg Thr Leu Leu Thr Ala Arg Gln Pro Pro Pro Pro Ala Val
            20                  25                  30          
Ala Leu Leu Ser Arg Trp Ser Val Arg Pro Ala His Val Thr Met Gly
        35                  40                  45              
Lys Ser Arg Thr Lys Arg Phe Lys Arg Pro Gln Phe Ser Pro Thr Gly
    50                  55                  60                  
Asp Cys Gln Ala Glu Ala Ala Ala Ala Ala Asn Gly Thr Gly Gly Glu
65                  70                  75                  80  
Glu Asp Asp Gly Pro Ala Ala Glu Leu Leu Glu Lys Leu Gln His Pro
                85                  90                  95      
Ser Ala Glu Val Arg Glu Cys Ala Cys Ala Gly Leu Ala Arg Leu Val
            100                 105                 110         
Gln Gln Arg Pro Ala Leu Pro Gly Leu Ala Arg Arg Asp Ala Val Arg
        115                 120                 125             
Arg Leu Gly Pro Leu Leu Leu Asp Pro Ser Leu Ala Val Arg Glu Thr
    130                 135                 140                 
Ala Ala Gly Ala Leu Arg Asn Leu Ser Ala Cys Gly Gly Phe Glu Val
145                 150                 155                 160 
Cys Asp Asp Met Val Thr Lys Asp Ile Met Thr Pro Leu Val Ala Leu
                165                 170                 175     
Leu Lys Glu Cys Ser Ala Gly Leu Asp Ser Asn Glu Met Ser Leu Gln
            180                 185                 190         
Glu Lys Lys Asp Gln Asn Arg Asn Ser Ile Glu Asn Ile Ala Asn Glu
        195                 200                 205             
Thr Val Asn Val Leu Trp Asn Ile Cys Glu Cys Ser Ser Arg Ala Val
    210                 215                 220                 
Ser Ile Phe Asn Lys Glu Gly Cys Leu Glu Ile Val Leu Lys Tyr Leu
225                 230                 235                 240 
Ser Arg Phe Pro Thr Asn Val Asp Leu Ala Ile Ser Val Ala Tyr Cys
                245                 250                 255     
Leu Gln Thr Val Thr Glu Asp Asn Pro Glu Leu Leu Lys Ser Phe Ser
            260                 265                 270         
Ala Thr Ala Leu Asn Met Leu Glu Ser Ala Leu Leu Ser Pro Val Ser
        275                 280                 285             
Ser Met Glu Ser Leu Leu Leu Lys Thr Leu Val Ala Gly Thr Ile Trp
    290                 295                 300                 
Asn Leu Lys Asp Ile Ile Pro Cys Lys Ser Gln Ala Glu Ile Ile Asn
305                 310                 315                 320 
Ala Leu Leu Lys Ile Leu Ser Glu Val Leu Gly Met Asp Ala Gly Glu
                325                 330                 335     
Met Val Ile Gln Met Lys Glu Ala Glu Thr Gln Arg Leu Lys Thr Ala
            340                 345                 350         
Ala Glu Ala Glu Glu Ile Leu Glu Asn Thr Asn Gly Asp Asp Leu Ile
        355                 360                 365             
Glu Asp Asp Glu Met Glu Gly Ile Ser His Lys Arg Arg Val Arg Arg
    370                 375                 380                 
Lys Thr Phe Val Ser Asp Leu Leu Pro Pro Thr Asp Lys Glu Leu Arg
385                 390                 395                 400 
Glu Thr Ile Ala Leu Leu Thr Ala Gln Gln Thr Ala Leu Glu Ile Ile
                405                 410                 415     
Val Asn Met Cys Cys Asn Glu Asp Pro Ser Asp Asp Glu Trp Glu Glu
            420                 425                 430         
Leu Ser Ser Ser Asp Glu Ser Asp Ala Phe Met Glu Asn Ser Phe Ser
        435                 440                 445             
Glu Cys Gly Gly Gln Leu Phe Ser Pro Leu Cys Leu Ser His Glu Val
    450                 455                 460                 
His Thr Ala Leu Thr Asn Tyr Leu Ile Pro Lys Lys Ile Phe Glu Lys
465                 470                 475                 480 
Thr Ala Phe Pro Asn Ser Ile Ala Val Asp Leu Cys Ser Arg Asn Pro
                485                 490                 495     
Thr Trp Lys Pro Leu Ile Arg Lys Met Asn Thr Ile Gln Cys Arg Ala
            500                 505                 510         
Leu Phe Cys Leu Gln Ser Leu Val Ser Leu Leu Asp Val Glu His Leu
        515                 520                 525             
Gly Gly Ala Ala Ala Leu Gln Thr Leu Ala Gln His Leu Ser Gln Leu
    530                 535                 540                 
Leu Phe Ser Gln Pro Asp Phe Ala Lys His Val Asp Phe Leu Glu Ala
545                 550                 555                 560 
Ile Ser Ser Ala Leu Arg Ala Leu Leu Gln Thr Met Ala Ser Lys Asn
                565                 570                 575     
Ile Ser Gln Cys Met Thr Pro Asp Gln Leu Met Thr Leu Cys Lys Ala
            580                 585                 590         
Gly Ile His Ser Ser Asn Val Gly Val Arg Val Asn Val Val Ser Ile
        595                 600                 605             
Leu Gly Ile Thr Gly Ser Val Leu Ala Lys Glu Asp Gly Thr Leu Glu
    610                 615                 620                 
Thr Leu Lys Asn Ile Gly Cys Phe Leu Leu Glu Val Thr Thr Lys Asp
625                 630                 635                 640 
Pro Ser Leu Val Val Ala Gly Glu Ala Leu Asp Ala Leu Phe Asp Val
                645                 650                 655     
Phe Ala Asp Gly Lys Glu Ala Glu Arg Ala Ser Ile Gln Ile Lys Leu
            660                 665                 670         
Leu Ser Ala Leu Lys Glu Phe Gln Pro Val Phe Lys Met Lys Ile Arg
        675                 680                 685             
Lys Glu Gly Arg Gly Asn Tyr Ser Thr Asp Gln Leu Cys Val Leu Asp
    690                 695                 700                 
Asn Val Lys Met Asn Leu Arg Arg Phe Ile Ala Tyr Gln Glu Thr Val
705                 710                 715                 720 
Glu Lys Arg Leu Thr Ser
                725     


<210> 8586
<211> 911
<212> PRT
<213> Homo sapiens

<400> 8586
Met Ala Ala Ser Gln Thr Ser Gln Thr Val Ala Ser His Val Pro Phe
 1               5                  10                  15      
Ala Asp Leu Cys Ser Thr Leu Glu Arg Ile Gln Lys Ser Lys Gly Arg
            20                  25                  30          
Ala Glu Lys Ile Arg His Phe Arg Glu Phe Leu Asp Ser Trp Arg Lys
        35                  40                  45              
Phe His Asp Ala Leu His Lys Asn His Lys Asp Val Thr Asp Ser Phe
    50                  55                  60                  
Tyr Pro Ala Met Arg Leu Ile Leu Pro Gln Leu Glu Arg Glu Arg Met
65                  70                  75                  80  
Ala Tyr Gly Ile Lys Glu Thr Met Leu Ala Lys Leu Tyr Ile Glu Leu
                85                  90                  95      
Leu Asn Leu Pro Arg Asp Gly Lys Asp Ala Leu Lys Leu Leu Asn Tyr
            100                 105                 110         
Arg Thr Pro Thr Gly Thr His Gly Asp Ala Gly Asp Phe Ala Met Ile
        115                 120                 125             
Ala Tyr Phe Val Leu Lys Pro Arg Cys Leu Gln Lys Gly Ser Leu Thr
    130                 135                 140                 
Ile Gln Gln Val Asn Asp Leu Leu Asp Ser Ile Ala Ser Asn Asn Ser
145                 150                 155                 160 
Ala Lys Arg Lys Asp Leu Ile Lys Lys Ser Leu Leu Gln Leu Ile Thr
                165                 170                 175     
Gln Ser Ser Ala Leu Glu Gln Lys Trp Leu Ile Arg Met Ile Ile Lys
            180                 185                 190         
Asp Leu Lys Leu Gly Val Ser Gln Gln Thr Ile Phe Ser Val Phe His
        195                 200                 205             
Asn Asp Ala Ala Glu Leu His Asn Val Thr Thr Asp Leu Glu Lys Val
    210                 215                 220                 
Cys Arg Gln Leu His Asp Pro Ser Val Gly Leu Ser Asp Ile Ser Ile
225                 230                 235                 240 
Thr Leu Phe Ser Ala Phe Lys Pro Met Leu Ala Ala Ile Ala Asp Ile
                245                 250                 255     
Glu His Ile Glu Lys Asp Met Lys His Gln Ser Phe Tyr Ile Glu Thr
            260                 265                 270         
Lys Leu Asp Gly Glu Arg Met Gln Met His Lys Asp Gly Asp Val Tyr
        275                 280                 285             
Lys Tyr Phe Ser Arg Asn Gly Tyr Asn Tyr Thr Asp Gln Phe Gly Ala
    290                 295                 300                 
Ser Pro Thr Glu Gly Ser Leu Thr Pro Phe Ile His Asn Ala Phe Lys
305                 310                 315                 320 
Ala Asp Ile Gln Ile Cys Ile Leu Asp Gly Glu Met Met Ala Tyr Asn
                325                 330                 335     
Pro Asn Thr Gln Thr Phe Met Gln Lys Gly Thr Lys Phe Asp Ile Lys
            340                 345                 350         
Arg Met Val Glu Asp Ser Asp Leu Gln Thr Cys Tyr Cys Val Phe Asp
        355                 360                 365             
Val Leu Met Val Asn Asn Lys Lys Leu Gly His Glu Thr Leu Arg Lys
    370                 375                 380                 
Arg Tyr Glu Ile Leu Ser Ser Ile Phe Thr Pro Ile Pro Gly Arg Ile
385                 390                 395                 400 
Glu Ile Val Gln Lys Thr Gln Ala His Thr Lys Asn Glu Val Ile Asp
                405                 410                 415     
Ala Leu Asn Glu Ala Ile Asp Lys Arg Glu Glu Gly Ile Met Val Lys
            420                 425                 430         
Gln Pro Leu Ser Ile Tyr Lys Pro Asp Lys Arg Gly Glu Gly Trp Leu
        435                 440                 445             
Lys Ile Lys Pro Glu Tyr Val Ser Gly Leu Met Asp Glu Leu Asp Ile
    450                 455                 460                 
Leu Ile Val Gly Gly Tyr Trp Gly Lys Gly Ser Arg Gly Gly Met Met
465                 470                 475                 480 
Ser His Phe Leu Cys Ala Val Ala Glu Lys Pro Pro Pro Gly Glu Lys
                485                 490                 495     
Pro Ser Val Phe His Thr Leu Ser Arg Val Gly Ser Gly Cys Thr Met
            500                 505                 510         
Lys Glu Leu Tyr Asp Leu Gly Leu Lys Leu Ala Lys Tyr Trp Lys Pro
        515                 520                 525             
Phe His Arg Lys Ala Pro Pro Ser Ser Ile Leu Cys Gly Thr Glu Lys
    530                 535                 540                 
Pro Glu Val Tyr Ile Glu Pro Cys Asn Ser Val Ile Val Gln Ile Lys
545                 550                 555                 560 
Ala Ala Glu Ile Val Pro Ser Asp Met Tyr Lys Thr Gly Cys Thr Leu
                565                 570                 575     
Arg Phe Pro Arg Ile Glu Lys Ile Arg Asp Asp Lys Glu Trp His Glu
            580                 585                 590         
Cys Met Thr Leu Asp Asp Leu Glu Gln Leu Arg Gly Lys Ala Ser Gly
        595                 600                 605             
Lys Leu Ala Ser Lys His Leu Tyr Ile Gly Gly Asp Asp Glu Pro Gln
    610                 615                 620                 
Glu Lys Lys Arg Lys Ala Ala Pro Lys Met Lys Lys Val Ile Gly Ile
625                 630                 635                 640 
Ile Glu His Leu Lys Ala Pro Asn Leu Thr Asn Val Asn Lys Ile Ser
                645                 650                 655     
Asn Ile Phe Glu Asp Val Glu Phe Cys Val Met Ser Gly Thr Asp Ser
            660                 665                 670         
Gln Pro Lys Pro Asp Leu Glu Asn Arg Ile Ala Glu Phe Gly Gly Tyr
        675                 680                 685             
Ile Val Gln Asn Pro Gly Pro Asp Thr Tyr Cys Val Ile Ala Gly Ser
    690                 695                 700                 
Glu Asn Ile Arg Val Lys Asn Ile Ile Leu Ser Asn Lys His Asp Val
705                 710                 715                 720 
Val Lys Pro Ala Trp Leu Leu Glu Cys Phe Lys Thr Lys Ser Phe Val
                725                 730                 735     
Pro Trp Gln Pro Arg Phe Met Ile His Met Cys Pro Ser Thr Lys Glu
            740                 745                 750         
His Phe Ala Arg Glu Tyr Asp Cys Tyr Gly Asp Ser Tyr Phe Ile Asp
        755                 760                 765             
Thr Asp Leu Asn Gln Leu Lys Glu Val Phe Ser Gly Ile Lys Asn Ser
    770                 775                 780                 
Asn Glu Gln Thr Pro Glu Glu Met Ala Ser Leu Ile Ala Asp Leu Glu
785                 790                 795                 800 
Tyr Arg Tyr Ser Trp Asp Cys Ser Pro Leu Ser Met Phe Arg Arg His
                805                 810                 815     
Thr Val Tyr Leu Asp Ser Tyr Ala Val Ile Asn Asp Leu Ser Thr Lys
            820                 825                 830         
Asn Glu Gly Thr Arg Leu Ala Ile Lys Ala Leu Glu Leu Arg Phe His
        835                 840                 845             
Gly Ala Lys Val Val Ser Cys Leu Ala Glu Gly Val Ser His Val Ile
    850                 855                 860                 
Ile Gly Glu Asp His Ser Arg Val Ala Asp Phe Lys Ala Phe Arg Arg
865                 870                 875                 880 
Thr Phe Lys Arg Lys Phe Lys Ile Leu Lys Glu Ser Trp Val Thr Asp
                885                 890                 895     
Ser Ile Asp Lys Cys Glu Leu Gln Glu Glu Asn Gln Tyr Leu Ile
            900                 905                 910     


<210> 8587
<211> 735
<212> PRT
<213> Homo sapiens

<400> 8587
Met Thr Pro Glu Leu Met Ile Lys Ala Cys Ser Phe Tyr Thr Gly His
 1               5                  10                  15      
Leu Val Lys Thr His Phe Cys Thr Trp Arg Asp Ile Ala Arg Thr Asn
            20                  25                  30          
Glu Asn Val Val Leu Ala Glu Lys Met Asn Arg Ala Val Thr Cys Tyr
        35                  40                  45              
Asn Phe Arg Leu Gln Lys Ser Val Phe His His Trp His Ser Tyr Met
    50                  55                  60                  
Glu Asp Gln Lys Glu Lys Leu Lys Asn Met Leu Leu Arg Ile Gln Gln
65                  70                  75                  80  
Ile Ile Tyr Cys His Lys Leu Thr Ile Ile Leu Thr Lys Trp Arg Asn
                85                  90                  95      
Thr Ala Arg His Lys Ser Lys Lys Lys Glu Asp Glu Leu Ile Leu Lys
            100                 105                 110         
His Glu Leu Gln Leu Lys Lys Trp Lys Asn Arg Leu Ile Leu Lys Arg
        115                 120                 125             
Ala Ala Ala Glu Glu Ser Asn Phe Pro Glu Arg Ser Ser Ser Glu Val
    130                 135                 140                 
Phe Leu Val Asp Glu Thr Leu Lys Cys Asp Ile Ser Leu Leu Pro Glu
145                 150                 155                 160 
Arg Ala Ile Leu Gln Ile Phe Phe Tyr Leu Ser Leu Lys Asp Val Ile
                165                 170                 175     
Ile Cys Gly Gln Val Asn His Ala Trp Met Leu Met Thr Gln Leu Asn
            180                 185                 190         
Ser Leu Trp Asn Ala Ile Asp Phe Ser Ser Val Lys Asn Val Ile Pro
        195                 200                 205             
Asp Lys Tyr Ile Val Ser Thr Leu Gln Arg Trp Arg Leu Asn Val Leu
    210                 215                 220                 
Arg Leu Asn Phe Arg Gly Cys Leu Leu Arg Pro Lys Thr Phe Arg Ser
225                 230                 235                 240 
Val Ser His Cys Arg Asn Leu Gln Glu Leu Asn Val Ser Asp Cys Pro
                245                 250                 255     
Thr Phe Thr Asp Glu Ser Met Arg His Ile Ser Glu Gly Cys Pro Gly
            260                 265                 270         
Val Leu Cys Leu Asn Leu Ser Asn Thr Thr Ile Thr Asn Arg Thr Met
        275                 280                 285             
Arg Leu Leu Pro Arg His Phe His Asn Leu Gln Asn Leu Ser Leu Ala
    290                 295                 300                 
Tyr Cys Arg Arg Phe Thr Asp Lys Gly Leu Gln Tyr Leu Asn Leu Gly
305                 310                 315                 320 
Asn Gly Cys His Lys Leu Ile Tyr Leu Asp Leu Ser Gly Cys Thr Gln
                325                 330                 335     
Ile Ser Val Gln Gly Phe Arg Tyr Ile Ala Asn Ser Cys Thr Gly Ile
            340                 345                 350         
Met His Leu Thr Ile Asn Asp Met Pro Thr Leu Thr Asp Asn Cys Val
        355                 360                 365             
Lys Ala Leu Val Glu Lys Cys Ser Arg Ile Thr Ser Leu Val Phe Thr
    370                 375                 380                 
Gly Ala Pro His Ile Ser Asp Cys Thr Phe Arg Ala Leu Ser Ala Cys
385                 390                 395                 400 
Lys Leu Arg Lys Ile Arg Phe Glu Gly Asn Lys Arg Val Thr Asp Ala
                405                 410                 415     
Ser Phe Lys Phe Ile Asp Lys Asn Tyr Pro Asn Leu Ser His Ile Tyr
            420                 425                 430         
Met Ala Asp Cys Lys Gly Ile Thr Asp Ser Ser Leu Arg Ser Leu Ser
        435                 440                 445             
Pro Leu Lys Gln Leu Thr Val Leu Asn Leu Ala Asn Cys Val Arg Ile
    450                 455                 460                 
Gly Asp Met Gly Leu Lys Gln Phe Leu Asp Gly Pro Ala Ser Met Arg
465                 470                 475                 480 
Ile Arg Glu Leu Asn Leu Ser Asn Cys Val Arg Leu Ser Asp Ala Ser
                485                 490                 495     
Val Met Lys Leu Ser Glu Arg Cys Pro Asn Leu Asn Tyr Leu Ser Leu
            500                 505                 510         
Arg Asn Cys Glu His Leu Thr Ala Gln Gly Ile Gly Tyr Ile Val Asn
        515                 520                 525             
Ile Phe Ser Leu Val Ser Ile Asp Leu Ser Gly Thr Asp Ile Ser Asn
    530                 535                 540                 
Glu Gly Leu Asn Val Leu Ser Arg His Lys Lys Leu Lys Glu Leu Ser
545                 550                 555                 560 
Val Ser Glu Cys Tyr Arg Ile Thr Asp Asp Gly Ile Gln Ala Phe Cys
                565                 570                 575     
Lys Ser Ser Leu Ile Leu Glu His Leu Asp Val Ser Tyr Cys Ser Gln
            580                 585                 590         
Leu Ser Asp Met Ile Ile Lys Ala Leu Ala Ile Tyr Cys Ile Asn Leu
        595                 600                 605             
Thr Ser Leu Ser Ile Ala Gly Cys Pro Lys Ile Thr Asp Ser Ala Met
    610                 615                 620                 
Glu Met Leu Ser Ala Lys Cys His Tyr Leu His Ile Leu Asp Ile Ser
625                 630                 635                 640 
Gly Cys Val Leu Leu Thr Asp Gln Ile Leu Glu Asp Leu Gln Ile Gly
                645                 650                 655     
Cys Lys Gln Leu Arg Ile Leu Lys Met Gln Tyr Cys Thr Asn Ile Ser
            660                 665                 670         
Lys Lys Ala Ala Gln Arg Met Ser Ser Lys Val Gln Gln Gln Glu Tyr
        675                 680                 685             
Asn Thr Asn Asp Pro Pro Arg Trp Phe Gly Tyr Asp Arg Glu Gly Asn
    690                 695                 700                 
Pro Val Thr Glu Leu Asp Asn Ile Thr Ser Ser Lys Gly Ala Leu Glu
705                 710                 715                 720 
Leu Thr Val Lys Lys Ser Thr Tyr Ser Ser Glu Asp Gln Ala Ala
                725                 730                 735 


<210> 8588
<211> 1938
<212> PRT
<213> Homo sapiens

<400> 8588
Met Ser Ser Asp Ala Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Tyr
 1               5                  10                  15      
Leu Arg Lys Pro Glu Lys Glu Arg Ile Glu Ala Gln Asn Arg Pro Phe
            20                  25                  30          
Asp Ser Lys Lys Ala Cys Phe Val Ala Asp Asn Lys Glu Met Tyr Val
        35                  40                  45              
Lys Gly Met Ile Gln Thr Arg Glu Asn Asp Lys Val Ile Val Lys Thr
    50                  55                  60                  
Leu Asp Asp Arg Met Leu Thr Leu Asn Asn Asp Gln Val Phe Pro Met
65                  70                  75                  80  
Asn Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Met Thr His
                85                  90                  95      
Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Ala Ala Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Asp Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Asp Lys Lys Lys Glu
        195                 200                 205             
Thr Gln Pro Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile Gln
    210                 215                 220                 
Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn
225                 230                 235                 240 
Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala
                245                 250                 255     
Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys
            260                 265                 270         
Ser Arg Val Thr Phe Gln Leu Ser Ser Glu Arg Ser Tyr His Ile Phe
        275                 280                 285             
Tyr Gln Ile Met Ser Asn Lys Lys Pro Glu Leu Ile Asp Leu Leu Leu
    290                 295                 300                 
Ile Ser Thr Asn Pro Phe Asp Phe Pro Phe Val Ser Gln Gly Glu Val
305                 310                 315                 320 
Thr Val Ala Ser Ile Asp Asp Ser Glu Glu Leu Leu Ala Thr Asp Asn
                325                 330                 335     
Ala Ile Asp Ile Leu Gly Phe Ser Ser Glu Glu Lys Val Gly Ile Tyr
            340                 345                 350         
Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys Gln
        355                 360                 365             
Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala Asp
    370                 375                 380                 
Lys Ala Gly Tyr Leu Met Gly Leu Asn Ser Ala Glu Met Leu Lys Gly
385                 390                 395                 400 
Leu Cys Cys Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly
                405                 410                 415     
Gln Asn Val Gln Gln Val Thr Asn Ser Val Gly Ala Leu Ala Lys Ala
            420                 425                 430         
Val Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln Gln
        435                 440                 445             
Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile
    450                 455                 460                 
Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys Ile
465                 470                 475                 480 
Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe
                485                 490                 495     
Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Glu Phe
            500                 505                 510         
Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu Lys
        515                 520                 525             
Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys
    530                 535                 540                 
Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu Gly
545                 550                 555                 560 
Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Ala Glu
                565                 570                 575     
Ala His Phe Ser Leu Val His Tyr Ala Gly Thr Val Asp Tyr Asn Ile
            580                 585                 590         
Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val
        595                 600                 605             
Gly Leu Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Phe Leu Phe Ser
    610                 615                 620                 
Asn Tyr Ala Gly Ala Glu Thr Gly Asp Ser Gly Gly Ser Lys Lys Gly
625                 630                 635                 640 
Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Val Phe Arg
                645                 650                 655     
Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His
            660                 665                 670         
Phe Val Arg Cys Leu Ile Pro Asn Glu Thr Lys Thr Pro Gly Val Met
        675                 680                 685             
Asp His Tyr Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu
    690                 695                 700                 
Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala
705                 710                 715                 720 
Asp Phe Lys Gln Arg Tyr Arg Ile Leu Asn Ala Ser Ala Ile Pro Glu
                725                 730                 735     
Gly Gln Phe Ile Asp Ser Lys Asn Ala Ser Glu Lys Leu Leu Asn Ser
            740                 745                 750         
Ile Asp Val Asp Arg Glu Gln Phe Arg Phe Gly Asn Thr Lys Val Phe
        755                 760                 765             
Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys
    770                 775                 780                 
Leu Val Thr Leu Met Thr Ser Thr Gln Ala Val Cys Arg Gly Tyr Leu
785                 790                 795                 800 
Met Arg Val Glu Phe Lys Lys Met Met Glu Arg Arg Asp Ser Ile Phe
                805                 810                 815     
Cys Ile Gln Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His Trp Pro
            820                 825                 830         
Trp Met Asn Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu
        835                 840                 845             
Ala Glu Lys Glu Met Ala Thr Met Lys Glu Asp Phe Glu Arg Thr Lys
    850                 855                 860                 
Glu Glu Leu Ala Arg Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys
865                 870                 875                 880 
Met Val Ser Leu Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln
                885                 890                 895     
Ser Glu Thr Glu Asn Leu Met Asp Ala Glu Glu Arg Cys Glu Gly Leu
            900                 905                 910         
Ile Lys Ser Lys Ile Leu Leu Glu Ala Lys Val Lys Glu Leu Thr Glu
        915                 920                 925             
Arg Leu Glu Glu Glu Glu Glu Met Asn Ser Glu Leu Val Ala Lys Lys
    930                 935                 940                 
Arg Asn Leu Glu Asp Lys Cys Ser Ser Leu Lys Arg Asp Ile Asp Asp
945                 950                 955                 960 
Leu Glu Leu Thr Leu Thr Lys Val Glu Lys Glu Lys His Ala Thr Glu
                965                 970                 975     
Asn Lys Val Lys Asn Leu Ser Glu Glu Met Thr Ala Leu Glu Glu Asn
            980                 985                 990         
Ile Ser Lys Leu Thr Lys Glu Lys Lys Ser Leu Gln Glu Ala His Gln
        995                 1000                1005            
Gln Thr Leu Asp Asp Leu Gln Val Glu Glu Asp Lys Val Asn Gly Leu
    1010                1015                1020                
Ile Lys Ile Asn Ala Lys Leu Glu Gln Gln Thr Asp Asp Leu Glu Gly
1025                1030                1035                1040
Ser Leu Glu Gln Glu Lys Lys Leu Arg Ala Asp Leu Glu Arg Ala Lys
                1045                1050                1055    
Arg Lys Leu Glu Gly Asp Leu Lys Met Ser Gln Glu Ser Ile Met Asp
            1060                1065                1070        
Leu Glu Asn Glu Lys Gln Gln Ile Glu Glu Lys Leu Lys Lys Lys Glu
        1075                1080                1085            
Phe Glu Leu Ser Gln Leu Gln Ala Arg Ile Asp Asp Glu Gln Val His
    1090                1095                1100                
Ser Leu Gln Phe Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu
1105                1110                1115                1120
Glu Leu Glu Glu Glu Ile Glu Ala Glu His Thr Leu Arg Ala Lys Ile
                1125                1130                1135    
Glu Lys Gln Arg Ser Asp Leu Ala Arg Glu Leu Glu Glu Ile Ser Glu
            1140                1145                1150        
Arg Leu Glu Glu Ala Ser Gly Ala Thr Ser Ala Gln Ile Glu Met Asn
        1155                1160                1165            
Lys Lys Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu
    1170                1175                1180                
Ala Thr Leu Gln His Glu Ala Thr Ala Ala Thr Leu Arg Lys Lys Gln
1185                1190                1195                1200
Ala Asp Ser Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg
                1205                1210                1215    
Val Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Leu Lys Met Glu Ile
            1220                1225                1230        
Asp Asp Met Ala Ser Asn Ile Glu Ala Leu Ser Lys Ser Lys Ser Asn
        1235                1240                1245            
Ile Glu Arg Thr Cys Arg Thr Val Glu Asp Gln Phe Ser Glu Ile Lys
    1250                1255                1260                
Ala Lys Asp Glu Gln Gln Thr Gln Leu Ile His Asp Leu Asn Met Gln
1265                1270                1275                1280
Lys Ala Arg Leu Gln Thr Gln Asn Gly Glu Leu Ser His Arg Val Glu
                1285                1290                1295    
Glu Lys Glu Ser Leu Ile Ser Gln Leu Thr Lys Ser Lys Gln Ala Leu
            1300                1305                1310        
Thr Gln Gln Leu Glu Glu Leu Lys Arg Gln Met Glu Glu Glu Thr Lys
        1315                1320                1325            
Ala Lys Asn Ala Met Ala His Ala Leu Gln Ser Ser Arg His Asp Cys
    1330                1335                1340                
Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Ala Lys Ala Glu
1345                1350                1355                1360
Leu Gln Arg Ala Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Lys
                1365                1370                1375    
Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu
            1380                1385                1390        
Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln Glu Ala Glu Glu Lys Thr
        1395                1400                1405            
Glu Thr Ala Asn Ser Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg
    1410                1415                1420                
Leu Gln Gly Glu Val Glu Asp Leu Met Arg Asp Leu Glu Arg Ser His
1425                1430                1435                1440
Thr Ala Cys Ala Thr Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Val
                1445                1450                1455    
Leu Ala Glu Trp Lys Gln Lys Leu Asp Glu Ser Gln Ala Glu Leu Glu
            1460                1465                1470        
Ala Ala Gln Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Met
        1475                1480                1485            
Arg Asn Ala Tyr Glu Glu Val Val Asp Gln Leu Glu Thr Leu Arg Arg
    1490                1495                1500                
Glu Asn Lys Asn Leu Gln Glu Glu Ile Ser Asp Leu Thr Glu Gln Ile
1505                1510                1515                1520
Ala Glu Thr Gly Lys Asn Leu Gln Glu Ala Glu Lys Thr Lys Lys Leu
                1525                1530                1535    
Val Glu Gln Glu Lys Ser Asp Leu Gln Val Ala Leu Glu Glu Val Glu
            1540                1545                1550        
Gly Ser Leu Glu His Glu Glu Ser Lys Ile Leu Arg Val Gln Leu Glu
        1555                1560                1565            
Leu Ser Gln Val Lys Ser Glu Leu Asp Arg Lys Val Ile Glu Lys Asp
    1570                1575                1580                
Glu Glu Ile Glu Gln Leu Lys Arg Asn Ser Gln Arg Ala Ala Glu Ala
1585                1590                1595                1600
Leu Gln Ser Val Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp Ala Leu
                1605                1610                1615    
Arg Leu Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln
            1620                1625                1630        
Leu Gly His Ser Asn Arg Gln Met Ala Glu Thr Gln Arg His Leu Arg
        1635                1640                1645            
Thr Val Gln Gly Gln Leu Lys Asp Ser Gln Leu His Leu Asp Asp Ala
    1650                1655                1660                
Leu Arg Ser Asn Glu Asp Leu Lys Glu Gln Leu Ala Ile Val Glu Arg
1665                1670                1675                1680
Arg Asn Gly Leu Leu Leu Glu Glu Leu Glu Glu Met Lys Val Ala Leu
                1685                1690                1695    
Glu Gln Thr Glu Arg Thr Arg Arg Leu Ser Glu Gln Glu Leu Leu Asp
            1700                1705                1710        
Ala Ser Asp Arg Val Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile
        1715                1720                1725            
Asn Thr Lys Lys Lys Leu Glu Ala Asp Ile Ala Gln Cys Gln Ala Glu
    1730                1735                1740                
Val Glu Asn Ser Ile Gln Glu Ser Arg Asn Ala Glu Glu Lys Ala Lys
1745                1750                1755                1760
Lys Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu
                1765                1770                1775    
Gln Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln
            1780                1785                1790        
Thr Val Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala
        1795                1800                1805            
Leu Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Asn Arg Val Arg
    1810                1815                1820                
Glu Leu Glu Asn Glu Leu Asp Val Glu Gln Lys Arg Gly Ala Glu Ala
1825                1830                1835                1840
Leu Lys Gly Ala His Lys Tyr Glu Arg Lys Val Lys Glu Met Thr Tyr
                1845                1850                1855    
Gln Ala Glu Glu Asp Arg Lys Asn Ile Leu Arg Leu Gln Asp Leu Val
            1860                1865                1870        
Asp Lys Leu Gln Ala Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu
        1875                1880                1885            
Ala Glu Glu Gln Ala Asn Thr Gln Leu Ser Arg Cys Arg Arg Val Gln
    1890                1895                1900                
His Glu Leu Glu Glu Ala Ala Glu Arg Ala Asp Ile Ala Glu Ser Gln
1905                1910                1915                1920
Val Asn Lys Leu Arg Ala Lys Ser Arg Asp Val Gly Ser Gln Lys Met
                1925                1930                1935    
Glu Glu
        


<210> 8589
<211> 1770
<212> PRT
<213> Homo sapiens

<400> 8589
Met Ser Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn
 1               5                  10                  15      
Ser Arg Glu Thr Ser Lys Glu Ser Lys Cys Ile Ile Gln Met Gln Gly
            20                  25                  30          
Asn Ser Thr Ser Ile Ile Asn Pro Lys Asn Pro Lys Glu Ala Pro Lys
        35                  40                  45              
Ser Phe Ser Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp
    50                  55                  60                  
Pro Cys Phe Ala Ser Gln Asn Arg Val Tyr Asn Asp Ile Gly Lys Glu
65                  70                  75                  80  
Met Leu Leu His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr
                85                  90                  95      
Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu
            100                 105                 110         
Glu Ser Gln Ala Gly Ile Ile Pro Gln Leu Cys Glu Glu Leu Phe Glu
        115                 120                 125             
Thr Asn His Asp Asn Cys Asn Glu Glu Met Ser Tyr Ser Val Glu Val
    130                 135                 140                 
Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro
145                 150                 155                 160 
Lys Asn Lys Gly Asn Leu Arg Val Arg Asp His Pro Leu Arg Gly Pro
                165                 170                 175     
Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Thr Asp Ile
            180                 185                 190         
Ala Asp Leu Met Asp Ala Gly Asn Lys Ala Arg Thr Val Ala Ala Thr
        195                 200                 205             
Asn Met Asn Glu Thr Ser Ser Arg Ser His Val Val Tyr Thr Ile Val
    210                 215                 220                 
Phe Thr Gln Lys Lys His Asp Asn Glu Thr Ile Leu Ala Thr Val Lys
225                 230                 235                 240 
Val Ser Lys Thr Ser Leu Val Asp Leu Ala Gly Ser Asp Arg Ala Ala
                245                 250                 255     
Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Ile Ile Asn
            260                 265                 270         
Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Val
        275                 280                 285             
Ser Lys Lys Lys Lys Lys Thr Asp Phe Ile Pro Tyr Arg Asp Ser Val
    290                 295                 300                 
Leu Thr Trp Leu Leu Arg Glu Asn Leu Gly Gly Asn Ser Arg Thr Ala
305                 310                 315                 320 
Met Val Ala Ala Leu Ser Pro Ala Asp Ile Asn Tyr Asp Glu Thr Leu
                325                 330                 335     
Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Gln Ile Lys Cys Asn Ala
            340                 345                 350         
Val Ile Asn Glu Asp Pro Asn Ala Lys Leu Val Arg Glu Leu Lys Glu
        355                 360                 365             
Glu Val Thr Arg Leu Lys Asp Leu Leu Arg Ala Gln Gly Leu Gly Asp
    370                 375                 380                 
Ile Ile Asp Thr Ser Met Gly Ser Leu Thr Ser Ser Pro Ser Ser Cys
385                 390                 395                 400 
Ser Leu Ser Ser Gln Val Gly Leu Thr Ser Val Thr Ser Ile Gln Glu
                405                 410                 415     
Arg Ile Met Ser Thr Pro Gly Gly Glu Glu Ala Ile Glu Arg Leu Lys
            420                 425                 430         
Glu Ser Glu Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys
        435                 440                 445             
Leu Arg Lys Thr Glu Ala Ile Arg Met Glu Arg Glu Ala Leu Leu Ala
    450                 455                 460                 
Glu Met Gly Val Ala Ile Arg Glu Asp Gly Gly Thr Leu Gly Val Phe
465                 470                 475                 480 
Ser Pro Lys Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu
                485                 490                 495     
Met Ser Glu Cys Leu Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val
            500                 505                 510         
Gly Gln Ala Asp Ala Glu Arg Arg Gln Asp Ile Val Leu Ser Gly Ala
        515                 520                 525             
His Ile Lys Glu Glu His Cys Ile Phe Arg Ser Glu Arg Ser Asn Ser
    530                 535                 540                 
Gly Glu Val Ile Val Thr Leu Glu Pro Cys Glu Arg Ser Glu Thr Tyr
545                 550                 555                 560 
Val Asn Gly Lys Arg Val Ser Gln Pro Val Gln Leu Arg Ser Gly Asn
                565                 570                 575     
Arg Ile Ile Met Gly Lys Asn His Val Phe Arg Phe Asn His Pro Glu
            580                 585                 590         
Gln Ala Arg Ala Glu Arg Glu Lys Thr Pro Ser Ala Glu Thr Pro Ser
        595                 600                 605             
Glu Pro Val Asp Trp Thr Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln
    610                 615                 620                 
Gly Ile Asp Met Lys Gln Glu Met Glu Lys Arg Leu Gln Glu Met Glu
625                 630                 635                 640 
Ile Leu Tyr Lys Lys Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln
                645                 650                 655     
Gln Arg Leu Asp Tyr Glu Ser Lys Leu Gln Ala Leu Gln Lys Gln Val
            660                 665                 670         
Glu Thr Arg Ser Leu Ala Ala Glu Thr Thr Glu Glu Glu Glu Glu Glu
        675                 680                 685             
Glu Glu Val Pro Trp Thr Gln His Glu Phe Glu Leu Ala Gln Trp Ala
    690                 695                 700                 
Phe Arg Lys Trp Lys Ser His Gln Phe Thr Ser Leu Arg Asp Leu Leu
705                 710                 715                 720 
Trp Gly Asn Ala Val Tyr Leu Lys Glu Ala Asn Ala Ile Ser Val Glu
                725                 730                 735     
Leu Lys Lys Lys Val Gln Phe Gln Phe Val Leu Leu Thr Asp Thr Leu
            740                 745                 750         
Tyr Ser Pro Leu Pro Pro Glu Leu Leu Pro Thr Glu Met Glu Lys Thr
        755                 760                 765             
His Glu Asp Arg Pro Phe Pro Arg Thr Val Val Ala Val Glu Val Gln
    770                 775                 780                 
Asp Leu Lys Asn Gly Ala Thr His Tyr Trp Ser Leu Glu Lys Leu Lys
785                 790                 795                 800 
Gln Arg Leu Asp Leu Met Arg Glu Met Tyr Asp Arg Ala Gly Glu Met
                805                 810                 815     
Ala Ser Ser Ala Gln Asp Glu Ser Glu Thr Thr Val Thr Gly Ser Asp
            820                 825                 830         
Pro Phe Tyr Asp Arg Phe His Trp Phe Lys Leu Val Gly Ser Ser Pro
        835                 840                 845             
Ile Phe His Gly Cys Val Asn Glu Arg Leu Ala Asp Arg Thr Pro Ser
    850                 855                 860                 
Pro Thr Phe Ser Thr Ala Asp Ser Asp Ile Thr Glu Leu Ala Asp Glu
865                 870                 875                 880 
Gln Gln Asp Glu Met Glu Asp Phe Asp Asp Glu Ala Phe Val Asp Asp
                885                 890                 895     
Ala Gly Ser Asp Ala Gly Thr Glu Glu Gly Ser Asp Leu Phe Ser Asp
            900                 905                 910         
Gly His Asp Pro Phe Tyr Asp Arg Ser Pro Trp Phe Ile Leu Val Gly
        915                 920                 925             
Arg Ala Phe Val Tyr Leu Ser Asn Leu Leu Tyr Pro Val Pro Leu Ile
    930                 935                 940                 
His Arg Val Ala Ile Val Ser Glu Lys Gly Glu Val Arg Gly Phe Leu
945                 950                 955                 960 
Arg Val Ala Val Gln Ala Ile Ala Ala Asp Glu Glu Ala Pro Asp Tyr
                965                 970                 975     
Gly Ser Gly Ile Arg Gln Ser Gly Thr Ala Lys Ile Ser Phe Asp Asn
            980                 985                 990         
Glu Tyr Phe Asn Gln Ser Asp Phe Ser Ser Val Ala Met Thr Arg Ser
        995                 1000                1005            
Gly Leu Ser Leu Glu Glu Leu Arg Ile Val Glu Gly Gln Gly Gln Ser
    1010                1015                1020                
Ser Glu Val Ile Thr Pro Pro Glu Glu Ile Ser Arg Ile Asn Asp Leu
1025                1030                1035                1040
Asp Leu Lys Ser Ser Thr Leu Leu Asp Gly Lys Met Val Met Glu Gly
                1045                1050                1055    
Phe Ser Glu Glu Ile Gly Asn His Leu Lys Leu Gly Ser Ala Phe Thr
            1060                1065                1070        
Phe Arg Val Thr Val Leu Gln Ala Ser Gly Ile Leu Pro Glu Tyr Ala
        1075                1080                1085            
Asp Ile Phe Cys Gln Phe Asn Phe Leu His Arg His Asp Glu Ala Phe
    1090                1095                1100                
Ser Thr Glu Pro Leu Lys Asn Asn Gly Arg Gly Ser Pro Leu Ala Phe
1105                1110                1115                1120
Tyr His Val Gln Asn Ile Ala Val Glu Ile Thr Glu Ser Phe Val Asp
                1125                1130                1135    
Tyr Ile Lys Thr Lys Pro Ile Val Phe Glu Val Phe Gly His Tyr Gln
            1140                1145                1150        
Gln His Pro Leu His Leu Gln Gly Gln Glu Leu Asn Ser Pro Pro Gln
        1155                1160                1165            
Pro Cys Arg Arg Phe Phe Pro Pro Pro Met Pro Leu Ser Lys Pro Val
    1170                1175                1180                
Pro Ala Thr Lys Leu Asn Thr Met Ser Lys Thr Ser Leu Gly Gln Ser
1185                1190                1195                1200
Met Ser Lys Tyr Asp Leu Leu Val Trp Phe Glu Ile Ser Glu Leu Glu
                1205                1210                1215    
Pro Thr Gly Glu Tyr Ile Pro Ala Val Val Asp His Thr Ala Gly Leu
            1220                1225                1230        
Pro Cys Gln Gly Thr Phe Leu Leu His Gln Gly Ile Gln Arg Arg Ile
        1235                1240                1245            
Thr Val Thr Ile Ile His Glu Lys Gly Ser Glu Leu His Trp Lys Asp
    1250                1255                1260                
Val Arg Glu Leu Val Val Gly Arg Ile Arg Asn Lys Pro Glu Val Asp
1265                1270                1275                1280
Glu Ala Ala Val Asp Ala Ile Leu Ser Leu Asn Ile Ile Ser Ala Lys
                1285                1290                1295    
Tyr Leu Lys Ser Ser His Asn Ser Ser Arg Thr Phe Tyr Arg Phe Glu
            1300                1305                1310        
Ala Val Trp Asp Ser Ser Leu His Asn Ser Leu Leu Leu Asn Arg Val
        1315                1320                1325            
Thr Pro Tyr Gly Glu Lys Ile Tyr Met Thr Leu Ser Ala Tyr Leu Glu
    1330                1335                1340                
Leu Asp His Cys Ile Gln Pro Ala Val Ile Thr Lys Asp Val Cys Met
1345                1350                1355                1360
Val Phe Tyr Ser Arg Asp Ala Lys Ile Ser Pro Pro Arg Ser Leu Arg
                1365                1370                1375    
Ser Leu Phe Gly Ser Gly Tyr Ser Lys Ser Pro Asp Ser Asn Arg Val
            1380                1385                1390        
Thr Gly Ile Tyr Glu Leu Ser Leu Cys Lys Met Ser Asp Thr Gly Ser
        1395                1400                1405            
Pro Gly Met Gln Arg Arg Arg Arg Lys Ile Leu Asp Thr Ser Val Ala
    1410                1415                1420                
Tyr Val Arg Gly Glu Glu Asn Leu Ala Gly Trp Arg Pro Arg Gly Asp
1425                1430                1435                1440
Ser Leu Ile Leu Glu His Gln Trp Glu Leu Glu Lys Leu Glu Leu Leu
                1445                1450                1455    
His Glu Val Glu Lys Thr Arg His Phe Leu Leu Leu Arg Glu Arg Leu
            1460                1465                1470        
Gly Asp Ser Ile Pro Lys Ser Leu Ser Asp Ser Leu Ser Pro Ser Leu
        1475                1480                1485            
Ser Ser Gly Thr Leu Ser Thr Ser Thr Ser Ile Ser Ser Gln Ile Ser
    1490                1495                1500                
Thr Thr Thr Phe Glu Ser Ala Ile Thr Pro Ser Glu Ser Ser Gly Tyr
1505                1510                1515                1520
Asp Ser Gly Asp Ile Glu Ser Leu Val Asp Arg Glu Lys Glu Leu Ala
                1525                1530                1535    
Thr Lys Cys Leu Gln Leu Leu Thr His Thr Phe Asn Arg Glu Phe Ser
            1540                1545                1550        
Gln Val His Gly Ser Val Ser Asp Cys Lys Leu Ser Asp Ile Ser Pro
        1555                1560                1565            
Ile Gly Arg Asp Pro Ser Glu Ser Ser Phe Ser Ser Ala Thr Leu Thr
    1570                1575                1580                
Pro Ser Ser Thr Cys Pro Ser Leu Val Asp Ser Arg Ser Asn Ser Leu
1585                1590                1595                1600
Asp Gln Lys Thr Pro Glu Ala Asn Ser Arg Ala Ser Ser Pro Cys Pro
                1605                1610                1615    
Glu Phe Glu Gln Phe Gln Ile Val Pro Ala Val Glu Thr Pro Tyr Leu
            1620                1625                1630        
Ala Arg Ala Gly Lys Asn Glu Phe Leu Asn Leu Val Pro Asp Ile Glu
        1635                1640                1645            
Glu Ile Arg Pro Ser Ser Val Val Ser Lys Lys Gly Tyr Leu His Phe
    1650                1655                1660                
Lys Glu Pro Leu Tyr Ser Asn Trp Ala Lys His Phe Val Val Val Arg
1665                1670                1675                1680
Arg Pro Tyr Val Phe Ile Tyr Asn Ser Asp Lys Asp Pro Val Glu Arg
                1685                1690                1695    
Gly Ile Ile Asn Leu Ser Thr Ala Gln Val Glu Tyr Ser Glu Asp Gln
            1700                1705                1710        
Gln Ala Met Val Lys Thr Pro Asn Thr Phe Ala Val Cys Thr Lys His
        1715                1720                1725            
Arg Gly Val Leu Leu Gln Ala Leu Asn Asp Lys Asp Met Asn Asp Trp
    1730                1735                1740                
Leu Tyr Ala Phe Asn Pro Leu Leu Ala Gly Thr Ile Arg Ser Lys Leu
1745                1750                1755                1760
Ser Arg Arg Cys Pro Ser Gln Ser Lys Tyr
                1765                1770


<210> 8590
<211> 1816
<212> PRT
<213> Homo sapiens

<400> 8590
Met Ser Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn
 1               5                  10                  15      
Ser Arg Glu Thr Ser Lys Glu Ser Lys Cys Ile Ile Gln Met Gln Gly
            20                  25                  30          
Asn Ser Thr Ser Ile Ile Asn Pro Lys Asn Pro Lys Glu Ala Pro Lys
        35                  40                  45              
Ser Phe Ser Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp
    50                  55                  60                  
Pro Cys Phe Ala Ser Gln Asn Arg Val Tyr Asn Asp Ile Gly Lys Glu
65                  70                  75                  80  
Met Leu Leu His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr
                85                  90                  95      
Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu
            100                 105                 110         
Glu Ser Gln Ala Gly Ile Ile Pro Gln Leu Cys Glu Glu Leu Phe Glu
        115                 120                 125             
Thr Asn His Asp Asn Cys Asn Glu Glu Met Ser Tyr Ser Val Glu Val
    130                 135                 140                 
Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro
145                 150                 155                 160 
Lys Asn Lys Gly Asn Leu Arg Val Arg Asp His Pro Leu Arg Gly Pro
                165                 170                 175     
Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Thr Asp Ile
            180                 185                 190         
Ala Asp Leu Met Asp Ala Gly Asn Lys Ala Arg Thr Val Ala Ala Thr
        195                 200                 205             
Asn Met Asn Glu Thr Ser Ser Arg Ser His Val Val Tyr Thr Ile Val
    210                 215                 220                 
Phe Thr Gln Lys Lys His Asp Asn Glu Thr Ile Leu Ala Thr Val Lys
225                 230                 235                 240 
Val Ser Lys Thr Ser Leu Val Asp Leu Ala Gly Ser Asp Arg Ala Ala
                245                 250                 255     
Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Ile Ile Asn
            260                 265                 270         
Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Val
        275                 280                 285             
Asp Asn Cys Thr Ser Lys Ser Lys Lys Lys Lys Lys Thr Asp Phe Ile
    290                 295                 300                 
Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Arg Glu Asn Leu Gly
305                 310                 315                 320 
Gly Asn Ser Arg Thr Ala Met Val Ala Ala Leu Ser Pro Ala Asp Ile
                325                 330                 335     
Asn Tyr Asp Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys
            340                 345                 350         
Gln Ile Lys Cys Asn Ala Val Ile Asn Glu Asp Pro Asn Ala Lys Leu
        355                 360                 365             
Val Arg Glu Leu Lys Glu Glu Val Thr Arg Leu Lys Asp Leu Leu Arg
    370                 375                 380                 
Ala Gln Gly Leu Gly Asp Ile Ile Asp Ile Asp Pro Leu Ile Asp Asp
385                 390                 395                 400 
Tyr Ser Gly Ser Gly Ser Lys Tyr Leu Lys Asp Phe Gln Asn Asn Lys
                405                 410                 415     
His Arg Tyr Leu Leu Ala Ser Glu Asn Gln Arg Pro Gly His Phe Ser
            420                 425                 430         
Thr Ala Ser Met Gly Ser Leu Thr Ser Ser Pro Ser Ser Cys Ser Leu
        435                 440                 445             
Ser Ser Gln Val Gly Leu Thr Ser Val Thr Ser Ile Gln Glu Arg Ile
    450                 455                 460                 
Met Ser Thr Pro Gly Gly Glu Glu Ala Ile Glu Arg Leu Lys Glu Ser
465                 470                 475                 480 
Glu Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys Leu Arg
                485                 490                 495     
Lys Thr Glu Ala Ile Arg Met Glu Arg Glu Ala Leu Leu Ala Glu Met
            500                 505                 510         
Gly Val Ala Ile Arg Glu Asp Gly Gly Thr Leu Gly Val Phe Ser Pro
        515                 520                 525             
Lys Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu Met Ser
    530                 535                 540                 
Glu Cys Leu Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val Gly Gln
545                 550                 555                 560 
Ala Asp Ala Glu Arg Arg Gln Asp Ile Val Leu Ser Gly Ala His Ile
                565                 570                 575     
Lys Glu Glu His Cys Ile Phe Arg Ser Glu Arg Ser Asn Ser Gly Glu
            580                 585                 590         
Val Ile Val Thr Leu Glu Pro Cys Glu Arg Ser Glu Thr Tyr Val Asn
        595                 600                 605             
Gly Lys Arg Val Ser Gln Pro Val Gln Leu Arg Ser Gly Asn Arg Ile
    610                 615                 620                 
Ile Met Gly Lys Asn His Val Phe Arg Phe Asn His Pro Glu Gln Ala
625                 630                 635                 640 
Arg Ala Glu Arg Glu Lys Thr Pro Ser Ala Glu Thr Pro Ser Glu Pro
                645                 650                 655     
Val Asp Trp Thr Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln Gly Ile
            660                 665                 670         
Asp Met Lys Gln Glu Met Glu Lys Arg Leu Gln Glu Met Glu Ile Leu
        675                 680                 685             
Tyr Lys Lys Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln Gln Arg
    690                 695                 700                 
Leu Asp Tyr Glu Ser Lys Leu Gln Ala Leu Gln Lys Gln Val Glu Thr
705                 710                 715                 720 
Arg Ser Leu Ala Ala Glu Thr Thr Glu Glu Glu Glu Glu Glu Glu Glu
                725                 730                 735     
Val Pro Trp Thr Gln His Glu Phe Glu Leu Ala Gln Trp Ala Phe Arg
            740                 745                 750         
Lys Trp Lys Ser His Gln Phe Thr Ser Leu Arg Asp Leu Leu Trp Gly
        755                 760                 765             
Asn Ala Val Tyr Leu Lys Glu Ala Asn Ala Ile Ser Val Glu Leu Lys
    770                 775                 780                 
Lys Lys Val Gln Phe Gln Phe Val Leu Leu Thr Asp Thr Leu Tyr Ser
785                 790                 795                 800 
Pro Leu Pro Pro Glu Leu Leu Pro Thr Glu Met Glu Lys Thr His Glu
                805                 810                 815     
Asp Arg Pro Phe Pro Arg Thr Val Val Ala Val Glu Val Gln Asp Leu
            820                 825                 830         
Lys Asn Gly Ala Thr His Tyr Trp Ser Leu Glu Lys Leu Lys Gln Arg
        835                 840                 845             
Leu Asp Leu Met Arg Glu Met Tyr Asp Arg Ala Gly Glu Met Ala Ser
    850                 855                 860                 
Ser Ala Gln Asp Glu Ser Glu Thr Thr Val Thr Gly Ser Asp Pro Phe
865                 870                 875                 880 
Tyr Asp Arg Phe His Trp Phe Lys Leu Val Gly Ser Ser Pro Ile Phe
                885                 890                 895     
His Gly Cys Val Asn Glu Arg Leu Ala Asp Arg Thr Pro Ser Pro Thr
            900                 905                 910         
Phe Ser Thr Ala Asp Ser Asp Ile Thr Glu Leu Ala Asp Glu Gln Gln
        915                 920                 925             
Asp Glu Met Glu Asp Phe Asp Asp Glu Ala Phe Val Asp Asp Ala Gly
    930                 935                 940                 
Ser Asp Ala Gly Thr Glu Glu Gly Ser Asp Leu Phe Ser Asp Gly His
945                 950                 955                 960 
Asp Pro Phe Tyr Asp Arg Ser Pro Trp Phe Ile Leu Val Gly Arg Ala
                965                 970                 975     
Phe Val Tyr Leu Ser Asn Leu Leu Tyr Pro Val Pro Leu Ile His Arg
            980                 985                 990         
Val Ala Ile Val Ser Glu Lys Gly Glu Val Arg Gly Phe Leu Arg Val
        995                 1000                1005            
Ala Val Gln Ala Ile Ala Ala Asp Glu Glu Ala Pro Asp Tyr Gly Ser
    1010                1015                1020                
Gly Ile Arg Gln Ser Gly Thr Ala Lys Ile Ser Phe Asp Asn Glu Tyr
1025                1030                1035                1040
Phe Asn Gln Ser Asp Phe Ser Ser Val Ala Met Thr Arg Ser Gly Leu
                1045                1050                1055    
Ser Leu Glu Glu Leu Arg Ile Val Glu Gly Gln Gly Gln Ser Ser Glu
            1060                1065                1070        
Val Ile Thr Pro Pro Glu Glu Ile Ser Arg Ile Asn Asp Leu Asp Leu
        1075                1080                1085            
Lys Ser Ser Thr Leu Leu Asp Gly Lys Met Val Met Glu Gly Phe Ser
    1090                1095                1100                
Glu Glu Ile Gly Asn His Leu Lys Leu Gly Ser Ala Phe Thr Phe Arg
1105                1110                1115                1120
Val Thr Val Leu Gln Ala Ser Gly Ile Leu Pro Glu Tyr Ala Asp Ile
                1125                1130                1135    
Phe Cys Gln Phe Asn Phe Leu His Arg His Asp Glu Ala Phe Ser Thr
            1140                1145                1150        
Glu Pro Leu Lys Asn Asn Gly Arg Gly Ser Pro Leu Ala Phe Tyr His
        1155                1160                1165            
Val Gln Asn Ile Ala Val Glu Ile Thr Glu Ser Phe Val Asp Tyr Ile
    1170                1175                1180                
Lys Thr Lys Pro Ile Val Phe Glu Val Phe Gly His Tyr Gln Gln His
1185                1190                1195                1200
Pro Leu His Leu Gln Gly Gln Glu Leu Asn Ser Pro Pro Gln Pro Cys
                1205                1210                1215    
Arg Arg Phe Phe Pro Pro Pro Met Pro Leu Ser Lys Pro Val Pro Ala
            1220                1225                1230        
Thr Lys Leu Asn Thr Met Ser Lys Thr Ser Leu Gly Gln Ser Met Ser
        1235                1240                1245            
Lys Tyr Asp Leu Leu Val Trp Phe Glu Ile Ser Glu Leu Glu Pro Thr
    1250                1255                1260                
Gly Glu Tyr Ile Pro Ala Val Val Asp His Thr Ala Gly Leu Pro Cys
1265                1270                1275                1280
Gln Gly Thr Phe Leu Leu His Gln Gly Ile Gln Arg Arg Ile Thr Val
                1285                1290                1295    
Thr Ile Ile His Glu Lys Gly Ser Glu Leu His Trp Lys Asp Val Arg
            1300                1305                1310        
Glu Leu Val Val Gly Arg Ile Arg Asn Lys Pro Glu Val Asp Glu Ala
        1315                1320                1325            
Ala Val Asp Ala Ile Leu Ser Leu Asn Ile Ile Ser Ala Lys Tyr Leu
    1330                1335                1340                
Lys Ser Ser His Asn Ser Ser Arg Thr Phe Tyr Arg Phe Glu Ala Val
1345                1350                1355                1360
Trp Asp Ser Ser Leu His Asn Ser Leu Leu Leu Asn Arg Val Thr Pro
                1365                1370                1375    
Tyr Gly Glu Lys Ile Tyr Met Thr Leu Ser Ala Tyr Leu Glu Leu Asp
            1380                1385                1390        
His Cys Ile Gln Pro Ala Val Ile Thr Lys Asp Val Cys Met Val Phe
        1395                1400                1405            
Tyr Ser Arg Asp Ala Lys Ile Ser Pro Pro Arg Ser Leu Arg Ser Leu
    1410                1415                1420                
Phe Gly Ser Gly Tyr Ser Lys Ser Pro Asp Ser Asn Arg Val Thr Gly
1425                1430                1435                1440
Ile Tyr Glu Leu Ser Leu Cys Lys Met Ser Asp Thr Gly Ser Pro Gly
                1445                1450                1455    
Met Gln Arg Arg Arg Arg Lys Ile Leu Asp Thr Ser Val Ala Tyr Val
            1460                1465                1470        
Arg Gly Glu Glu Asn Leu Ala Gly Trp Arg Pro Arg Gly Asp Ser Leu
        1475                1480                1485            
Ile Leu Glu His Gln Trp Glu Leu Glu Lys Leu Glu Leu Leu His Glu
    1490                1495                1500                
Val Glu Lys Thr Arg His Phe Leu Leu Leu Arg Glu Arg Leu Gly Asp
1505                1510                1515                1520
Ser Ile Pro Lys Ser Leu Ser Asp Ser Leu Ser Pro Ser Leu Ser Ser
                1525                1530                1535    
Gly Thr Leu Ser Thr Ser Thr Ser Ile Ser Ser Gln Ile Ser Thr Thr
            1540                1545                1550        
Thr Phe Glu Ser Ala Ile Thr Pro Ser Glu Ser Ser Gly Tyr Asp Ser
        1555                1560                1565            
Gly Asp Ile Glu Ser Leu Val Asp Arg Glu Lys Glu Leu Ala Thr Lys
    1570                1575                1580                
Cys Leu Gln Leu Leu Thr His Thr Phe Asn Arg Glu Phe Ser Gln Val
1585                1590                1595                1600
His Gly Ser Val Ser Asp Cys Lys Leu Ser Asp Ile Ser Pro Ile Gly
                1605                1610                1615    
Arg Asp Pro Ser Glu Ser Ser Phe Ser Ser Ala Thr Leu Thr Pro Ser
            1620                1625                1630        
Ser Thr Cys Pro Ser Leu Val Asp Ser Arg Ser Asn Ser Leu Asp Gln
        1635                1640                1645            
Lys Thr Pro Glu Ala Asn Ser Arg Ala Ser Ser Pro Cys Pro Glu Phe
    1650                1655                1660                
Glu Gln Phe Gln Ile Val Pro Ala Val Glu Thr Pro Tyr Leu Ala Arg
1665                1670                1675                1680
Ala Gly Lys Asn Glu Phe Leu Asn Leu Val Pro Asp Ile Glu Glu Ile
                1685                1690                1695    
Arg Pro Ser Ser Val Val Ser Lys Lys Gly Tyr Leu His Phe Lys Glu
            1700                1705                1710        
Pro Leu Tyr Ser Asn Trp Ala Lys His Phe Val Val Val Arg Arg Pro
        1715                1720                1725            
Tyr Val Phe Ile Tyr Asn Ser Asp Lys Asp Pro Val Glu Arg Gly Ile
    1730                1735                1740                
Ile Asn Leu Ser Thr Ala Gln Val Glu Tyr Ser Glu Asp Gln Gln Ala
1745                1750                1755                1760
Met Val Lys Thr Pro Asn Thr Phe Ala Val Cys Thr Lys His Arg Gly
                1765                1770                1775    
Val Leu Leu Gln Ala Leu Asn Asp Lys Asp Met Asn Asp Trp Leu Tyr
            1780                1785                1790        
Ala Phe Asn Pro Leu Leu Ala Gly Thr Ile Arg Ser Lys Leu Ser Arg
        1795                1800                1805            
Arg Cys Pro Ser Gln Ser Lys Tyr
    1810                1815    


<210> 8591
<211> 2785
<212> PRT
<213> Homo sapiens

<400> 8591
Met Lys Thr Lys Pro Val Ser His Lys Thr Glu Asn Thr Tyr Arg Phe
 1               5                  10                  15      
Leu Thr Phe Ala Glu Arg Leu Gly Asn Val Asn Ile Asp Ile Ile His
            20                  25                  30          
Arg Ile Asp Arg Thr Ala Ser Tyr Glu Glu Glu Val Glu Thr Tyr Phe
        35                  40                  45              
Phe Glu Gly Leu Leu Lys Trp Arg Glu Leu Asn Leu Thr Glu His Phe
    50                  55                  60                  
Gly Lys Phe Tyr Lys Glu Val Ile Asp Lys Cys Gln Ser Phe Asn Gln
65                  70                  75                  80  
Leu Val Tyr His Gln Asn Glu Ile Val Gln Ser Leu Lys Thr His Leu
                85                  90                  95      
Gln Val Lys Asn Ser Phe Ala Tyr Gln Pro Leu Leu Asp Leu Val Val
            100                 105                 110         
Gln Leu Ala Arg Asp Leu Gln Met Asp Phe Tyr Pro His Phe Pro Glu
        115                 120                 125             
Phe Phe Leu Thr Ile Thr Ser Ile Leu Glu Thr Gln Asp Thr Glu Leu
    130                 135                 140                 
Leu Glu Trp Ala Phe Thr Ser Leu Ser Tyr Leu Tyr Lys Tyr Leu Trp
145                 150                 155                 160 
Arg Leu Met Val Lys Asp Met Ser Ser Ile Tyr Ser Met Tyr Ser Thr
                165                 170                 175     
Leu Leu Ala His Lys Lys Leu His Ile Arg Asn Phe Ala Ala Glu Ser
            180                 185                 190         
Phe Thr Phe Leu Met Arg Lys Val Ser Asp Lys Asn Ala Leu Phe Asn
        195                 200                 205             
Leu Met Phe Leu Asp Leu Asp Lys His Pro Glu Lys Val Glu Gly Val
    210                 215                 220                 
Gly Gln Leu Leu Phe Glu Met Cys Lys Gly Val Arg Asn Met Phe His
225                 230                 235                 240 
Ser Cys Thr Gly Gln Ala Val Lys Leu Ile Leu Arg Lys Leu Gly Pro
                245                 250                 255     
Val Thr Glu Thr Glu Thr Gln Leu Pro Trp Met Leu Ile Gly Glu Thr
            260                 265                 270         
Leu Lys Asn Met Val Lys Ser Thr Val Ser Tyr Ile Ser Lys Glu His
        275                 280                 285             
Phe Gly Thr Phe Phe Glu Cys Leu Gln Glu Ser Leu Leu Asp Leu His
    290                 295                 300                 
Thr Lys Val Thr Lys Thr Asn Cys Cys Glu Ser Ser Glu Gln Ile Lys
305                 310                 315                 320 
Arg Leu Leu Glu Thr Tyr Leu Ile Leu Val Lys His Gly Ser Gly Thr
                325                 330                 335     
Lys Ile Pro Thr Pro Ala Asp Val Cys Lys Val Leu Ser Gln Thr Leu
            340                 345                 350         
Gln Val Ala Ser Leu Ser Thr Ser Cys Trp Glu Thr Leu Leu Asp Val
        355                 360                 365             
Ile Ser Ala Leu Ile Leu Gly Glu Asn Val Ser Leu Pro Glu Thr Leu
    370                 375                 380                 
Ile Lys Glu Thr Ile Glu Lys Ile Phe Glu Ser Arg Phe Glu Lys Arg
385                 390                 395                 400 
Leu Ile Phe Ser Phe Ser Glu Val Met Phe Ala Met Lys Gln Phe Glu
                405                 410                 415     
Gln Leu Phe Leu Pro Ser Phe Leu Ser Tyr Ile Val Asn Cys Phe Leu
            420                 425                 430         
Ile Asp Asp Ala Val Val Lys Asp Glu Ala Leu Ala Ile Leu Ala Lys
        435                 440                 445             
Leu Ile Leu Asn Lys Ala Ala Pro Pro Thr Ala Gly Ser Met Ala Ile
    450                 455                 460                 
Glu Lys Tyr Pro Leu Val Phe Ser Pro Gln Met Val Gly Phe Tyr Ile
465                 470                 475                 480 
Lys Gln Lys Lys Thr Arg Ser Lys Gly Arg Asn Glu Gln Phe Pro Val
                485                 490                 495     
Leu Asp His Leu Leu Ser Ile Ile Lys Leu Pro Pro Asn Lys Asp Thr
            500                 505                 510         
Thr Tyr Leu Ser Gln Ser Trp Ala Ala Leu Val Val Leu Pro His Ile
        515                 520                 525             
Arg Pro Leu Glu Lys Glu Lys Val Ile Pro Leu Val Thr Gly Phe Ile
    530                 535                 540                 
Glu Ala Leu Phe Met Thr Val Asp Lys Gly Ser Phe Gly Lys Gly Asn
545                 550                 555                 560 
Leu Phe Val Leu Cys Gln Ala Val Asn Thr Leu Leu Ser Leu Glu Glu
                565                 570                 575     
Ser Ser Glu Leu Leu His Leu Val Pro Val Glu Arg Val Lys Asn Leu
            580                 585                 590         
Val Leu Thr Phe Pro Leu Glu Pro Ser Val Leu Leu Leu Thr Asp Leu
        595                 600                 605             
Tyr Tyr Gln Arg Leu Ala Leu Cys Gly Cys Lys Gly Pro Leu Ser Gln
    610                 615                 620                 
Glu Ala Leu Met Glu Leu Phe Pro Lys Leu Gln Ala Asn Ile Ser Thr
625                 630                 635                 640 
Gly Val Ser Lys Ile Arg Leu Leu Thr Ile Arg Ile Leu Asn His Phe
                645                 650                 655     
Asp Val Gln Leu Pro Glu Ser Met Glu Asp Asp Gly Leu Ser Glu Arg
            660                 665                 670         
Gln Ser Val Phe Ala Ile Leu Arg Gln Ala Glu Leu Val Pro Ala Thr
        675                 680                 685             
Val Asn Asp Tyr Arg Glu Lys Leu Leu His Leu Arg Lys Leu Arg His
    690                 695                 700                 
Asp Val Val Gln Thr Ala Val Pro Asp Gly Pro Leu Gln Glu Val Pro
705                 710                 715                 720 
Leu Arg Tyr Leu Leu Gly Met Leu Tyr Ile Asn Phe Ser Ala Leu Trp
                725                 730                 735     
Asp Pro Val Ile Glu Leu Ile Ser Ser His Ala His Glu Met Glu Asn
            740                 745                 750         
Lys Gln Phe Trp Lys Val Tyr Tyr Glu His Leu Glu Lys Ala Ala Thr
        755                 760                 765             
His Ala Glu Lys Glu Leu Gln Asn Asp Met Thr Asp Glu Lys Ser Val
    770                 775                 780                 
Gly Asp Glu Ser Trp Glu Gln Thr Gln Glu Gly Asp Val Gly Ala Leu
785                 790                 795                 800 
Tyr His Glu Gln Leu Ala Leu Lys Thr Asp Cys Gln Glu Arg Leu Asp
                805                 810                 815     
His Thr Asn Phe Arg Phe Leu Leu Trp Arg Ala Leu Thr Lys Phe Pro
            820                 825                 830         
Glu Arg Val Glu Pro Arg Ser Arg Glu Leu Ser Pro Leu Phe Leu Arg
        835                 840                 845             
Phe Ile Asn Asn Glu Tyr Tyr Pro Ala Asp Leu Gln Val Ala Pro Thr
    850                 855                 860                 
Gln Asp Leu Arg Arg Lys Gly Lys Gly Met Val Ala Glu Glu Ile Glu
865                 870                 875                 880 
Glu Glu Pro Ala Ala Gly Asp Asp Glu Glu Leu Glu Glu Glu Ala Val
                885                 890                 895     
Pro Gln Asp Glu Ser Ser Gln Lys Lys Lys Thr Arg Arg Ala Ala Ala
            900                 905                 910         
Lys Gln Leu Ile Ala His Leu Gln Val Phe Ser Lys Phe Ser Asn Pro
        915                 920                 925             
Arg Ala Leu Tyr Leu Glu Ser Lys Leu Tyr Glu Leu Tyr Leu Gln Leu
    930                 935                 940                 
Leu Leu His Gln Asp Gln Met Val Gln Lys Ile Thr Leu Asp Cys Ile
945                 950                 955                 960 
Met Thr Tyr Lys His Pro His Val Leu Pro Tyr Arg Glu Asn Leu Gln
                965                 970                 975     
Arg Leu Leu Glu Asp Arg Ser Phe Lys Glu Glu Ile Val His Phe Ser
            980                 985                 990         
Ile Ser Glu Asp Asn Ala Val Val Lys Thr Ala His Arg Ala Asp Leu
        995                 1000                1005            
Phe Pro Ile Leu Met Arg Ile Leu Tyr Gly Arg Met Lys Asn Lys Thr
    1010                1015                1020                
Gly Ser Lys Thr Gln Gly Lys Ser Ala Ser Gly Thr Arg Met Ala Ile
1025                1030                1035                1040
Val Leu Arg Phe Leu Ala Gly Thr Gln Pro Glu Glu Ile Gln Ile Phe
                1045                1050                1055    
Leu Asp Leu Leu Phe Glu Pro Val Arg His Phe Lys Asn Gly Glu Cys
            1060                1065                1070        
His Ser Ala Val Ile Gln Ala Val Glu Asp Leu Asp Leu Ser Lys Val
        1075                1080                1085            
Leu Pro Leu Gly Arg Gln His Gly Ile Leu Asn Ser Leu Glu Ile Val
    1090                1095                1100                
Leu Lys Asn Ile Ser His Leu Ile Ser Ala Tyr Leu Pro Lys Ile Leu
1105                1110                1115                1120
Gln Ile Leu Leu Cys Met Thr Ala Thr Val Ser His Ile Leu Asp Gln
                1125                1130                1135    
Arg Glu Lys Ile Gln Leu Arg Phe Ile Asn Pro Leu Lys Asn Leu Arg
            1140                1145                1150        
Arg Leu Gly Ile Lys Met Val Thr Asp Ile Phe Leu Asp Trp Glu Ser
        1155                1160                1165            
Tyr Gln Phe Arg Thr Glu Glu Ile Asp Ala Val Phe His Gly Ala Val
    1170                1175                1180                
Trp Pro Gln Ile Ser Arg Leu Gly Ser Glu Ser Gln Tyr Ser Pro Thr
1185                1190                1195                1200
Pro Leu Leu Lys Leu Ile Ser Ile Trp Ser Arg Asn Ala Arg Tyr Phe
                1205                1210                1215    
Pro Leu Leu Ala Lys Gln Lys Pro Gly His Pro Glu Cys Asp Ile Leu
            1220                1225                1230        
Thr Asn Val Phe Ala Ile Leu Ser Ala Lys Asn Leu Ser Asp Ala Thr
        1235                1240                1245            
Ala Ser Ile Val Met Asp Ile Val Asp Asp Leu Leu Asn Leu Pro Asp
    1250                1255                1260                
Phe Glu Pro Thr Glu Thr Val Leu Asn Leu Leu Val Thr Gly Cys Val
1265                1270                1275                1280
Tyr Pro Gly Ile Ala Glu Asn Ile Gly Glu Ser Ile Thr Ile Gly Gly
                1285                1290                1295    
Arg Leu Ile Leu Pro His Val Pro Ala Ile Leu Gln Tyr Leu Ser Lys
            1300                1305                1310        
Thr Thr Ile Ser Ala Glu Lys Val Lys Lys Lys Lys Asn Arg Ala Gln
        1315                1320                1325            
Val Ser Lys Glu Leu Gly Ile Leu Ser Lys Ile Ser Lys Phe Met Lys
    1330                1335                1340                
Asp Lys Glu Gln Ser Ser Val Leu Ile Thr Leu Leu Leu Pro Phe Leu
1345                1350                1355                1360
His Arg Gly Asn Ile Ala Glu Asp Thr Glu Val Asp Ile Leu Val Thr
                1365                1370                1375    
Val Gln Asn Leu Leu Lys His Cys Val Asp Pro Thr Ser Phe Leu Lys
            1380                1385                1390        
Pro Ile Ala Lys Leu Phe Ser Val Ile Lys Asn Lys Leu Ser Arg Lys
        1395                1400                1405            
Leu Leu Cys Thr Val Phe Glu Thr Leu Ser Asp Phe Glu Ser Gly Leu
    1410                1415                1420                
Lys Tyr Ile Thr Asp Val Val Lys Leu Asn Ala Phe Asp Gln Arg His
1425                1430                1435                1440
Leu Asp Asp Ile Asn Phe Asp Val Arg Phe Glu Thr Phe Gln Thr Ile
                1445                1450                1455    
Thr Ser Tyr Ile Lys Glu Met Gln Ile Val Asp Val Asn Tyr Leu Ile
            1460                1465                1470        
Pro Val Met His Asn Cys Phe Tyr Asn Leu Glu Leu Gly Asp Met Ser
        1475                1480                1485            
Leu Ser Asp Asn Ala Ser Met Cys Leu Met Ser Ile Ile Lys Lys Leu
    1490                1495                1500                
Pro Ala Leu Asn Val Thr Glu Lys Asp Tyr Arg Glu Ile Ile His Arg
1505                1510                1515                1520
Ser Leu Leu Glu Lys Leu Arg Lys Gly Leu Lys Ser Gln Thr Glu Ser
                1525                1530                1535    
Ile Gln Gln Asp Tyr Thr Thr Ile Leu Ser Cys Leu Ile Gln Thr Phe
            1540                1545                1550        
Pro Asn Gln Leu Glu Phe Lys Asp Leu Val Gln Leu Thr His Tyr His
        1555                1560                1565            
Asp Pro Glu Met Asp Phe Phe Glu Asn Met Lys His Ile Gln Ile His
    1570                1575                1580                
Arg Arg Ala Arg Ala Leu Lys Lys Leu Ala Lys Gln Leu Met Glu Gly
1585                1590                1595                1600
Lys Val Val Leu Ser Ser Lys Ser Leu Gln Asn Tyr Ile Met Pro Tyr
                1605                1610                1615    
Ala Met Thr Pro Ile Phe Asp Glu Lys Met Leu Lys His Glu Asn Ile
            1620                1625                1630        
Thr Thr Ala Ala Thr Glu Ile Ile Gly Ala Ile Cys Lys His Leu Ser
        1635                1640                1645            
Trp Ser Ala Tyr Met Tyr Tyr Leu Lys His Phe Ile His Val Leu Gln
    1650                1655                1660                
Thr Gly Gln Ile Asn Gln Lys Leu Gly Val Ser Leu Leu Val Ile Val
1665                1670                1675                1680
Leu Glu Ala Phe His Phe Asp His Lys Thr Leu Glu Glu Gln Met Gly
                1685                1690                1695    
Lys Ile Glu Asn Glu Glu Asn Ala Ile Glu Ala Ile Glu Leu Pro Glu
            1700                1705                1710        
Pro Glu Ala Met Glu Leu Glu Arg Val Asp Glu Glu Glu Lys Glu Tyr
        1715                1720                1725            
Thr Cys Lys Ser Leu Ser Asp Asn Gly Gln Pro Gly Thr Pro Asp Pro
    1730                1735                1740                
Ala Asp Ser Gly Gly Thr Ser Ala Lys Glu Ser Glu Cys Ile Thr Lys
1745                1750                1755                1760
Pro Val Ser Phe Leu Pro Gln Asn Lys Glu Glu Ile Glu Arg Thr Ile
                1765                1770                1775    
Lys Asn Ile Gln Gly Thr Ile Thr Gly Asp Ile Leu Pro Arg Leu His
            1780                1785                1790        
Lys Cys Leu Ala Ser Thr Thr Lys Arg Glu Glu Glu His Lys Leu Val
        1795                1800                1805            
Lys Ser Lys Val Val Asn Asp Glu Glu Val Val Arg Val Pro Leu Ala
    1810                1815                1820                
Phe Ala Met Val Lys Leu Met Gln Ser Leu Pro Gln Glu Val Met Glu
1825                1830                1835                1840
Ala Asn Leu Pro Ser Ile Leu Leu Lys Val Cys Ala Leu Leu Lys Asn
                1845                1850                1855    
Arg Ala Gln Glu Ile Arg Asp Ile Ala Arg Ser Thr Leu Ala Lys Ile
            1860                1865                1870        
Ile Glu Asp Leu Gly Val His Phe Leu Gln Tyr Val Leu Lys Glu Leu
        1875                1880                1885            
Gln Thr Thr Leu Val Arg Gly Tyr Gln Val His Val Leu Thr Phe Thr
    1890                1895                1900                
Val His Met Leu Leu Gln Gly Leu Thr Asn Lys Leu Gln Val Gly Asp
1905                1910                1915                1920
Leu Asp Ser Cys Leu Asp Ile Met Ile Glu Ile Phe Asn His Glu Leu
                1925                1930                1935    
Phe Gly Ala Val Ala Glu Glu Lys Glu Val Lys Gln Ile Leu Ser Lys
            1940                1945                1950        
Val Met Glu Ala Arg Arg Ser Lys Ser Tyr Asp Ser Tyr Glu Ile Leu
        1955                1960                1965            
Gly Lys Phe Val Gly Lys Asp Gln Val Thr Lys Leu Ile Leu Pro Leu
    1970                1975                1980                
Lys Glu Ile Leu Gln Asn Thr Thr Ser Leu Lys Leu Ala Arg Lys Val
1985                1990                1995                2000
His Glu Thr Leu Arg Arg Ile Thr Val Gly Leu Ile Val Asn Gln Glu
                2005                2010                2015    
Met Thr Ala Glu Ser Ile Leu Leu Leu Ser Tyr Gly Leu Ile Ser Glu
            2020                2025                2030        
Asn Leu Pro Leu Leu Thr Glu Lys Glu Lys Asn Pro Val Ala Pro Ala
        2035                2040                2045            
Pro Asp Pro Arg Leu Pro Pro Gln Ser Cys Leu Leu Leu Pro Pro Thr
    2050                2055                2060                
Pro Val Arg Gly Gly Gln Lys Ala Val Val Ser Arg Lys Thr Asn Met
2065                2070                2075                2080
His Ile Phe Ile Glu Ser Gly Leu Arg Leu Leu His Leu Ser Leu Lys
                2085                2090                2095    
Thr Ser Lys Ile Lys Ser Ser Gly Glu Cys Val Leu Glu Met Leu Asp
            2100                2105                2110        
Pro Phe Val Ser Leu Leu Ile Asp Cys Leu Gly Ser Met Asp Val Lys
        2115                2120                2125            
Val Ile Thr Gly Ala Leu Gln Cys Leu Ile Trp Val Leu Arg Phe Pro
    2130                2135                2140                
Leu Pro Ser Ile Glu Thr Lys Ala Glu Gln Leu Thr Lys His Leu Phe
2145                2150                2155                2160
Leu Leu Leu Lys Asp Tyr Ala Lys Leu Gly Ala Ala Arg Gly Gln Asn
                2165                2170                2175    
Phe His Leu Val Val Asn Cys Phe Lys Cys Val Thr Ile Leu Val Lys
            2180                2185                2190        
Lys Val Lys Ser Tyr Gln Ile Thr Glu Lys Gln Leu Gln Val Leu Leu
        2195                2200                2205            
Ala Tyr Ala Glu Glu Asp Ile Tyr Asp Thr Ser Arg Gln Ala Thr Ala
    2210                2215                2220                
Phe Gly Leu Leu Lys Ala Ile Leu Ser Arg Lys Leu Leu Val Pro Glu
2225                2230                2235                2240
Ile Asp Glu Val Met Arg Lys Val Ser Lys Leu Ala Val Ser Ala Gln
                2245                2250                2255    
Ser Glu Pro Ala Arg Val Gln Cys Arg Gln Val Phe Leu Lys Tyr Ile
            2260                2265                2270        
Leu Asp Tyr Pro Leu Gly Asp Lys Leu Arg Pro Asn Leu Glu Phe Met
        2275                2280                2285            
Leu Ala Gln Leu Asn Tyr Glu His Glu Thr Gly Arg Glu Ser Thr Leu
    2290                2295                2300                
Glu Met Ile Ala Tyr Leu Phe Asp Thr Phe Pro Gln Gly Leu Leu His
2305                2310                2315                2320
Glu Asn Cys Gly Met Phe Phe Ile Pro Leu Cys Leu Met Thr Ile Asn
                2325                2330                2335    
Asp Asp Ser Ala Thr Cys Lys Lys Met Ala Ser Met Thr Ile Lys Ser
            2340                2345                2350        
Leu Leu Gly Lys Ile Ser Leu Glu Lys Lys Asp Trp Leu Phe Asp Met
        2355                2360                2365            
Val Thr Thr Trp Phe Gly Ala Lys Lys Arg Leu Asn Arg Gln Leu Ala
    2370                2375                2380                
Ala Leu Ile Cys Gly Leu Phe Val Glu Ser Glu Gly Val Asp Phe Glu
2385                2390                2395                2400
Lys Arg Leu Gly Thr Val Leu Pro Val Ile Glu Lys Glu Ile Asp Pro
                2405                2410                2415    
Glu Asn Phe Lys Asp Ile Met Glu Glu Thr Glu Glu Lys Ala Ala Asp
            2420                2425                2430        
Arg Leu Leu Phe Ser Phe Leu Thr Leu Ile Thr Lys Leu Ile Lys Glu
        2435                2440                2445            
Cys Asn Ile Ile Gln Phe Thr Lys Pro Ala Glu Thr Leu Ser Lys Ile
    2450                2455                2460                
Trp Ser His Val His Ser His Leu Arg His Pro His Asn Trp Val Trp
2465                2470                2475                2480
Leu Thr Ala Ala Gln Ile Phe Gly Leu Leu Phe Ala Ser Cys Gln Pro
                2485                2490                2495    
Glu Glu Leu Ile Gln Lys Trp Asn Thr Lys Lys Thr Lys Lys His Leu
            2500                2505                2510        
Pro Glu Pro Val Ala Ile Lys Phe Leu Ala Ser Asp Leu Asp Gln Lys
        2515                2520                2525            
Met Lys Ser Ile Ser Leu Ala Ser Cys His Gln Leu His Ser Lys Phe
    2530                2535                2540                
Leu Asp Gln Ser Leu Gly Glu Gln Val Val Lys Asn Leu Leu Phe Ala
2545                2550                2555                2560
Ala Lys Val Leu Tyr Leu Leu Glu Leu Tyr Cys Glu Asp Lys Gln Ser
                2565                2570                2575    
Lys Ile Lys Glu Asp Leu Glu Glu Gln Glu Ala Leu Glu Asp Gly Val
            2580                2585                2590        
Ala Cys Ala Asp Glu Lys Ala Glu Ser Asp Gly Glu Glu Lys Glu Glu
        2595                2600                2605            
Val Lys Glu Glu Leu Gly Arg Pro Ala Thr Leu Leu Trp Leu Ile Gln
    2610                2615                2620                
Lys Leu Ser Arg Ile Ala Lys Leu Glu Ala Ala Tyr Ser Pro Arg Asn
2625                2630                2635                2640
Pro Leu Lys Arg Thr Cys Ile Phe Lys Phe Leu Gly Ala Val Ala Met
                2645                2650                2655    
Asp Leu Gly Ile Asp Lys Val Lys Pro Tyr Leu Pro Met Ile Ile Ala
            2660                2665                2670        
Pro Leu Phe Arg Glu Leu Asn Ser Thr Tyr Ser Glu Gln Asp Pro Leu
        2675                2680                2685            
Leu Lys Asn Leu Ser Gln Glu Ile Ile Glu Leu Leu Lys Lys Leu Val
    2690                2695                2700                
Gly Leu Glu Ser Phe Ser Leu Ala Phe Ala Ser Val Gln Lys Gln Ala
2705                2710                2715                2720
Asn Glu Lys Arg Ala Leu Arg Lys Lys Arg Lys Ala Leu Glu Phe Val
                2725                2730                2735    
Thr Asn Pro Asp Ile Ala Ala Lys Lys Lys Met Lys Lys His Lys Asn
            2740                2745                2750        
Lys Ser Glu Ala Lys Lys Arg Lys Ile Glu Phe Leu Arg Pro Gly Tyr
        2755                2760                2765            
Lys Ala Lys Arg Gln Lys Ser His Ser Leu Lys Asp Leu Ala Met Val
    2770                2775                2780                
Glu
2785


<210> 8592
<211> 693
<212> PRT
<213> Homo sapiens

<400> 8592
Met Ile Ala Pro Leu Leu Cys Ile Leu Ser Tyr Asn Phe Asn Thr Phe
 1               5                  10                  15      
Ala Ile Leu Asn Val Tyr Ser Lys Leu Thr Met Phe Cys Thr Thr Asn
            20                  25                  30          
Ser Leu Pro Met Asp Leu Leu Leu Lys Gln Gly Ser Leu Lys Gln Glu
        35                  40                  45              
Val Glu Ser Phe Cys Tyr Gln Ile Val Ser Glu Ser Asn Asp Gln Lys
    50                  55                  60                  
Val Gly Ile Leu Gln Ser Glu Asp Lys Gln Leu Gln Pro Ser Val Ser
65                  70                  75                  80  
Lys Lys Ser Glu Gly Glu Leu Ser Arg Val Lys Phe Ile Ser Asn Ser
                85                  90                  95      
Asn Lys Ile Thr Phe Ser Lys Lys Pro Lys Arg Arg Lys Tyr Asp Glu
            100                 105                 110         
Ser Tyr Leu Ser Phe Gly Phe Thr Tyr Phe Gly Asn Arg Asp Ala Pro
        115                 120                 125             
His Ala Gln Cys Val Leu Cys Lys Lys Ile Leu Ser Asn Ser Ser Leu
    130                 135                 140                 
Ala Pro Ser Lys Leu Arg Arg His Leu Glu Thr Lys His Ala Ala Tyr
145                 150                 155                 160 
Lys Asp Lys Asp Ile Ser Phe Phe Lys Gln His Leu Asp Ser Pro Glu
                165                 170                 175     
Asn Asn Lys Pro Pro Thr Pro Lys Ile Val Asn Thr Asp Asn Glu Ser
            180                 185                 190         
Ala Thr Glu Ala Ser Tyr Asn Val Ser Tyr His Ile Ala Leu Ser Gly
        195                 200                 205             
Glu Ala His Thr Ile Gly Glu Leu Leu Ile Lys Pro Cys Ala Lys Asp
    210                 215                 220                 
Val Val Met Arg Met Phe Asp Glu Gln Tyr Ser Lys Lys Ile Asp Ala
225                 230                 235                 240 
Val Gln Leu Ser Asn Ser Thr Val Ala Arg Arg Ile Lys Asp Leu Ala
                245                 250                 255     
Ala Asp Ile Glu Glu Glu Leu Val Cys Arg Leu Lys Ile Cys Asp Gly
            260                 265                 270         
Phe Ser Leu Gln Leu Asp Glu Ser Ala Asp Val Ser Gly Leu Ala Val
        275                 280                 285             
Leu Leu Val Phe Val Arg Tyr Arg Phe Asn Lys Ser Ile Glu Glu Asp
    290                 295                 300                 
Leu Leu Leu Cys Glu Ser Leu Gln Ser Asn Ala Thr Gly Glu Glu Ile
305                 310                 315                 320 
Phe Asn Cys Ile Asn Ser Phe Met Gln Lys His Glu Ile Glu Trp Glu
                325                 330                 335     
Lys Cys Val Asp Val Cys Ser Asp Ala Ser Arg Ala Val Asp Gly Lys
            340                 345                 350         
Ile Ala Glu Ala Val Thr Leu Ile Lys Tyr Val Ala Pro Glu Ser Thr
        355                 360                 365             
Ser Ser His Cys Leu Leu Tyr Arg His Ala Leu Ala Val Lys Ile Met
    370                 375                 380                 
Pro Thr Ser Leu Lys Asn Val Leu Asp Gln Ala Val Gln Ile Ile Asn
385                 390                 395                 400 
Tyr Ile Lys Ala Arg Pro His Gln Ser Arg Leu Leu Lys Ile Leu Cys
                405                 410                 415     
Glu Glu Met Gly Ala Gln His Thr Ala Leu Leu Leu Asn Thr Glu Val
            420                 425                 430         
Arg Trp Leu Ser Arg Gly Lys Val Leu Val Arg Leu Phe Glu Leu Arg
        435                 440                 445             
Arg Glu Leu Leu Val Phe Met Asp Ser Ala Phe Arg Leu Ser Asp Cys
    450                 455                 460                 
Leu Thr Asn Ser Ser Trp Leu Leu Arg Leu Ala Tyr Leu Ala Asp Val
465                 470                 475                 480 
Phe Thr Lys Leu Asn Glu Val Asn Leu Ser Met Gln Gly Lys Asn Val
                485                 490                 495     
Thr Val Phe Thr Val Phe Asp Lys Met Ser Ser Leu Leu Arg Lys Leu
            500                 505                 510         
Glu Phe Trp Ala Ser Ser Val Glu Glu Glu Asn Phe Asp Cys Phe Pro
        515                 520                 525             
Thr Leu Ser Asp Phe Leu Thr Glu Ile Asn Ser Thr Val Asp Lys Asp
    530                 535                 540                 
Ile Cys Ser Ala Ile Val Gln His Leu Arg Gly Leu Arg Ala Thr Leu
545                 550                 555                 560 
Leu Lys Tyr Phe Pro Val Thr Asn Asp Asn Asn Ala Trp Val Arg Asn
                565                 570                 575     
Pro Phe Thr Val Thr Val Lys Pro Ala Ser Leu Val Ala Arg Asp Tyr
            580                 585                 590         
Glu Ser Leu Ile Asp Leu Thr Ser Asp Ser Gln Val Lys Gln Asn Phe
        595                 600                 605             
Ser Glu Leu Ser Leu Asn Asp Phe Trp Ser Ser Leu Ile Gln Glu Tyr
    610                 615                 620                 
Pro Ser Ile Ala Arg Arg Ala Val Arg Val Leu Leu Pro Phe Ala Thr
625                 630                 635                 640 
Met His Leu Cys Glu Thr Gly Phe Ser Tyr Tyr Ala Ala Thr Lys Thr
                645                 650                 655     
Lys Tyr Arg Lys Arg Leu Asp Ala Ala Pro His Met Arg Ile Arg Leu
            660                 665                 670         
Ser Asn Ile Thr Pro Asn Ile Lys Arg Ile Cys Asp Lys Lys Thr Gln
        675                 680                 685             
Lys His Cys Ser His
    690             


<210> 8593
<211> 335
<212> PRT
<213> Homo sapiens

<400> 8593
Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala Arg Arg Ile Asn Asp Glu
 1               5                  10                  15      
Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg Asp Ala Arg Arg Glu Leu
            20                  25                  30          
Lys Leu Leu Leu Leu Arg Thr Gly Glu Ser Gly Lys Ser Thr Phe Ile
        35                  40                  45              
Lys Gln Leu Arg Ile Ile His Gly Ser Gly Tyr Ser Asp Glu Asp Lys
    50                  55                  60                  
Arg Gly Phe Thr Lys Leu Val Tyr Arg Asn Ile Phe Thr Ala Met Gln
65                  70                  75                  80  
Ala Met Ile Arg Ala Ile Asp Ser Leu Lys Ile Pro Tyr Lys Tyr Glu
                85                  90                  95      
His Arg Glu Val Asp Val Glu Lys Gly Ser Ala Phe Glu Asn Pro Tyr
            100                 105                 110         
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys
        115                 120                 125             
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr
    130                 135                 140                 
Leu Asn Asp Leu Asp His Val Ala Asp Leu Ala Thr Gln Gln Asp Val
145                 150                 155                 160 
Leu Arg Val Arg Val Pro Thr Thr Gly Ile Val Glu Tyr Pro Phe Asp
                165                 170                 175     
Leu Gln Ser Val Ile Phe Arg Met Phe Asp Val Gly Gly Gln Arg Ser
            180                 185                 190         
Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met
        195                 200                 205             
Phe Leu Val Ala Leu Ser Glu Tyr Asp Arg Val Leu Val Glu Ser Asp
    210                 215                 220                 
Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Ser Thr Ile Ile
225                 230                 235                 240 
Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Leu Leu Asn Lys
                245                 250                 255     
Lys Asp Leu Pro Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp Tyr
            260                 265                 270         
Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu
        275                 280                 285             
Phe Ile Leu Lys Met Phe Val Pro Glu Pro Ser Asp Gln Ile Ile Tyr
    290                 295                 300                 
Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val Phe
305                 310                 315                 320 
Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Asp Tyr
                325                 330                 335 


<210> 8594
<211> 1180
<212> PRT
<213> Homo sapiens

<400> 8594
Met Thr Leu Gln Gly Arg Ala Asp Leu Ser Gly Asn Gln Gly Asn Ala
 1               5                  10                  15      
Ala Gly Arg Leu Ala Thr Val His Glu Pro Val Val Thr Gln Trp Ala
            20                  25                  30          
Val His Pro Pro Ala Pro Ala His Pro Ser Leu Leu Asp Lys Met Glu
        35                  40                  45              
Lys Ala Pro Pro Gln Pro Gln His Glu Gly Leu Lys Ser Lys Glu His
    50                  55                  60                  
Leu Pro Gln Gln Pro Ala Glu Gly Lys Thr Ala Ser Arg Arg Val Pro
65                  70                  75                  80  
Arg Leu Arg Ala Val Val Glu Ser Gln Ala Phe Lys Asn Ile Leu Val
                85                  90                  95      
Asp Glu Met Asp Met Met His Ala Arg Ala Ala Thr Leu Ile Gln Ala
            100                 105                 110         
Asn Trp Arg Gly Tyr Trp Leu Arg Gln Lys Leu Ile Ser Gln Met Met
        115                 120                 125             
Ala Ala Lys Ala Ile Gln Glu Ala Trp Arg Arg Phe Asn Lys Arg His
    130                 135                 140                 
Ile Leu His Ser Ser Lys Ser Leu Val Lys Lys Thr Arg Ala Glu Glu
145                 150                 155                 160 
Gly Asp Ile Pro Tyr His Ala Pro Gln Gln Val Arg Phe Gln His Pro
                165                 170                 175     
Glu Glu Asn Arg Leu Leu Ser Pro Pro Ile Met Val Asn Lys Glu Thr
            180                 185                 190         
Gln Phe Pro Ser Cys Asp Asn Leu Val Leu Cys Arg Pro Gln Ser Ser
        195                 200                 205             
Pro Leu Leu Gln Pro Pro Ala Ala Gln Gly Thr Pro Glu Pro Cys Val
    210                 215                 220                 
Gln Gly Pro His Ala Ala Arg Val Arg Gly Leu Ala Phe Leu Pro His
225                 230                 235                 240 
Gln Thr Val Thr Ile Arg Phe Pro Cys Pro Val Ser Leu Asp Ala Lys
                245                 250                 255     
Cys Gln Pro Cys Leu Leu Thr Arg Thr Ile Arg Ser Thr Cys Leu Val
            260                 265                 270         
His Ile Glu Gly Asp Ser Val Lys Thr Lys Arg Val Ser Ala Arg Thr
        275                 280                 285             
Asn Lys Ala Arg Ala Pro Glu Thr Pro Leu Ser Arg Arg Tyr Asp Gln
    290                 295                 300                 
Ala Val Thr Arg Pro Ser Arg Ala Gln Thr Gln Gly Pro Val Lys Ala
305                 310                 315                 320 
Glu Thr Pro Lys Ala Pro Phe Gln Ile Cys Pro Gly Pro Met Ile Thr
                325                 330                 335     
Lys Thr Leu Leu Gln Thr Tyr Pro Val Val Ser Val Thr Leu Pro Gln
            340                 345                 350         
Thr Tyr Pro Ala Ser Thr Met Thr Thr Thr Pro Pro Lys Thr Ser Pro
        355                 360                 365             
Val Pro Lys Val Thr Ile Ile Lys Thr Pro Ala Gln Met Tyr Pro Gly
    370                 375                 380                 
Pro Thr Val Thr Lys Thr Ala Pro His Thr Cys Pro Met Pro Thr Met
385                 390                 395                 400 
Thr Lys Ile Gln Val His Pro Thr Ala Ser Arg Thr Gly Thr Pro Arg
                405                 410                 415     
Gln Thr Cys Pro Ala Thr Ile Thr Ala Lys Asn Arg Pro Gln Val Ser
            420                 425                 430         
Leu Leu Ala Ser Ile Met Lys Ser Leu Pro Gln Val Cys Pro Gly Pro
        435                 440                 445             
Ala Met Ala Lys Thr Pro Pro Gln Met His Pro Val Thr Thr Pro Ala
    450                 455                 460                 
Lys Asn Pro Leu Gln Thr Cys Leu Ser Ala Thr Met Ser Lys Thr Ser
465                 470                 475                 480 
Ser Gln Arg Ser Pro Val Gly Val Thr Lys Pro Ser Pro Gln Thr Arg
                485                 490                 495     
Leu Pro Ala Met Ile Thr Lys Thr Pro Ala Gln Leu Arg Ser Val Ala
            500                 505                 510         
Thr Ile Leu Lys Thr Leu Cys Leu Ala Ser Pro Thr Val Ala Asn Val
        515                 520                 525             
Lys Ala Pro Pro Gln Val Ala Val Ala Ala Gly Thr Pro Asn Thr Ser
    530                 535                 540                 
Gly Ser Ile His Glu Asn Pro Pro Lys Ala Lys Ala Thr Val Asn Val
545                 550                 555                 560 
Lys Gln Ala Ala Lys Val Val Lys Ala Ser Ser Pro Ser Tyr Leu Ala
                565                 570                 575     
Glu Gly Lys Ile Arg Cys Leu Ala Gln Pro His Pro Gly Thr Gly Val
            580                 585                 590         
Pro Arg Ala Ala Ala Glu Leu Pro Leu Glu Ala Glu Lys Ile Lys Thr
        595                 600                 605             
Gly Thr Gln Lys Gln Ala Lys Thr Asp Met Ala Phe Lys Thr Ser Val
    610                 615                 620                 
Ala Val Glu Met Ala Gly Ala Pro Ser Trp Thr Lys Val Ala Glu Glu
625                 630                 635                 640 
Gly Asp Lys Pro Pro His Val Tyr Val Pro Val Asp Met Ala Val Thr
                645                 650                 655     
Leu Pro Arg Gly Gln Leu Ala Ala Pro Leu Thr Asn Ala Ser Ser Gln
            660                 665                 670         
Arg His Pro Pro Cys Leu Ser Gln Arg Pro Leu Ala Ala Pro Leu Thr
        675                 680                 685             
Lys Ala Ser Ser Gln Gly His Leu Pro Thr Glu Leu Thr Lys Thr Pro
    690                 695                 700                 
Ser Leu Ala His Leu Asp Thr Cys Leu Ser Lys Met His Ser Gln Thr
705                 710                 715                 720 
His Leu Ala Thr Gly Ala Val Lys Val Gln Ser Gln Ala Pro Leu Ala
                725                 730                 735     
Thr Cys Leu Thr Lys Thr Gln Ser Arg Gly Gln Pro Ile Thr Asp Ile
            740                 745                 750         
Thr Thr Cys Leu Ile Pro Ala His Gln Ala Ala Asp Leu Ser Ser Asn
        755                 760                 765             
Thr His Ser Gln Val Leu Leu Thr Gly Ser Lys Val Ser Asn His Ala
    770                 775                 780                 
Cys Gln Arg Leu Gly Gly Leu Ser Ala Pro Pro Trp Ala Lys Pro Glu
785                 790                 795                 800 
Asp Arg Gln Thr Gln Pro Gln Pro His Gly His Val Pro Gly Lys Thr
                805                 810                 815     
Thr Gln Gly Gly Pro Cys Pro Ala Ala Cys Glu Val Gln Gly Met Leu
            820                 825                 830         
Val Pro Pro Met Ala Pro Thr Gly His Ser Thr Cys Asn Val Glu Ser
        835                 840                 845             
Trp Gly Asp Asn Gly Ala Thr Arg Ala Gln Pro Ser Met Pro Gly Gln
    850                 855                 860                 
Ala Val Pro Cys Gln Glu Asp Thr Gly Pro Ala Asp Ala Gly Val Val
865                 870                 875                 880 
Gly Gly Gln Ser Trp Asn Arg Ala Trp Glu Pro Ala Arg Gly Ala Ala
                885                 890                 895     
Ser Trp Asp Thr Trp Arg Asn Lys Ala Val Val Pro Pro Arg Arg Ser
            900                 905                 910         
Gly Glu Pro Met Val Ser Met Gln Ala Ala Glu Glu Ile Arg Ile Leu
        915                 920                 925             
Ala Val Ile Thr Ile Gln Ala Gly Val Arg Gly Tyr Leu Ala Arg Arg
    930                 935                 940                 
Arg Ile Arg Leu Trp His Arg Gly Ala Met Val Ile Gln Ala Thr Trp
945                 950                 955                 960 
Arg Gly Tyr Arg Val Arg Arg Asn Leu Ala His Leu Cys Arg Ala Thr
                965                 970                 975     
Thr Thr Ile Gln Ser Ala Trp Arg Gly Tyr Ser Thr Arg Arg Asp Gln
            980                 985                 990         
Ala Arg His Trp Gln Met Leu His Pro Val Thr Trp Val Glu Leu Gly
        995                 1000                1005            
Ser Arg Ala Gly Val Met Ser Asp Arg Ser Trp Phe Gln Asp Gly Arg
    1010                1015                1020                
Ala Arg Thr Val Ser Asp His Arg Cys Phe Gln Ser Cys Gln Ala His
1025                1030                1035                1040
Ala Cys Ser Val Cys His Ser Leu Ser Ser Arg Ile Gly Ser Pro Pro
                1045                1050                1055    
Ser Val Val Met Leu Val Gly Ser Ser Pro Arg Thr Cys His Thr Cys
            1060                1065                1070        
Gly Arg Thr Gln Pro Thr Arg Val Val Gln Gly Met Gly Gln Gly Thr
        1075                1080                1085            
Glu Gly Pro Gly Ala Val Ser Trp Ala Ser Ala Tyr Gln Leu Ala Ala
    1090                1095                1100                
Leu Ser Pro Arg Gln Pro His Arg Gln Asp Lys Ala Ala Thr Ala Ile
1105                1110                1115                1120
Gln Ser Ala Trp Arg Gly Phe Lys Ile Arg Gln Gln Met Arg Gln Gln
                1125                1130                1135    
Gln Met Ala Ala Lys Ile Val Gln Ala Thr Trp Arg Gly His His Thr
            1140                1145                1150        
Arg Ser Cys Leu Lys Asn Thr Glu Ala Leu Leu Gly Pro Ala Asp Pro
        1155                1160                1165            
Ser Ala Ser Ser Arg His Met His Trp Pro Gly Ile
    1170                1175                1180


<210> 8595
<211> 907
<212> PRT
<213> Homo sapiens

<400> 8595
Met Ser Gly Gln Thr Leu Thr Asp Arg Ile Ala Ala Ala Gln Tyr Ser
 1               5                  10                  15      
Val Thr Gly Ser Ala Val Ala Arg Ala Val Cys Lys Ala Thr Thr His
            20                  25                  30          
Glu Val Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Ala
        35                  40                  45              
Thr Asn Glu Thr Asn Val Asn Ile Pro Gln Met Ala Asp Thr Leu Phe
    50                  55                  60                  
Glu Arg Ala Thr Asn Ser Ser Trp Val Val Val Phe Lys Ala Leu Val
65                  70                  75                  80  
Thr Thr His His Leu Met Val His Gly Asn Glu Arg Phe Ile Gln Tyr
                85                  90                  95      
Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys
            100                 105                 110         
Ser Gly Ser His Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser
        115                 120                 125             
Arg Tyr Leu Asn Glu Lys Ala Phe Ser Tyr Arg Gln Met Ala Phe Asp
    130                 135                 140                 
Phe Ala Arg Val Lys Lys Gly Ala Asp Gly Val Met Arg Thr Met Ala
145                 150                 155                 160 
Pro Glu Lys Leu Leu Lys Ser Met Pro Ile Leu Gln Gly Gln Ile Asp
                165                 170                 175     
Ala Leu Leu Glu Phe Asp Val His Pro Asn Glu Leu Thr Asn Gly Val
            180                 185                 190         
Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Leu Ile Lys Leu Phe
        195                 200                 205             
Ala Cys Tyr Asn Asp Gly Val Ile Asn Leu Leu Glu Lys Phe Phe Glu
    210                 215                 220                 
Met Lys Lys Gly Gln Cys Lys Asp Ala Leu Glu Ile Tyr Lys Arg Phe
225                 230                 235                 240 
Leu Thr Arg Met Thr Arg Val Ser Glu Phe Leu Lys Val Ala Glu Gln
                245                 250                 255     
Val Gly Ile Asp Lys Gly Asp Ile Pro Asp Leu Thr Gln Ala Pro Ser
            260                 265                 270         
Ser Leu Met Glu Thr Leu Glu Gln His Leu Asn Thr Leu Glu Gly Lys
        275                 280                 285             
Lys Pro Gly Asn Asn Glu Gly Ser Gly Ala Pro Ser Pro Leu Ser Lys
    290                 295                 300                 
Ser Ser Pro Ala Thr Thr Val Thr Ser Pro Asn Ser Thr Pro Ala Lys
305                 310                 315                 320 
Thr Ile Asp Thr Ser Pro Pro Val Asp Leu Phe Ala Thr Ala Ser Ala
                325                 330                 335     
Ala Val Pro Val Ser Thr Ser Lys Pro Ser Ser Asp Leu Leu Asp Leu
            340                 345                 350         
Gln Pro Asp Phe Ser Ser Gly Gly Ala Ala Ala Ala Ala Ala Pro Ala
        355                 360                 365             
Pro Pro Pro Pro Ala Gly Gly Ala Thr Ala Trp Gly Asp Leu Leu Gly
    370                 375                 380                 
Glu Asp Ser Leu Ala Ala Leu Ser Ser Val Pro Ser Glu Ala Gln Ile
385                 390                 395                 400 
Ser Asp Pro Phe Ala Pro Glu Pro Thr Pro Pro Thr Thr Thr Ala Glu
                405                 410                 415     
Ile Ala Thr Ala Ser Ala Ser Ala Ser Thr Thr Thr Thr Val Thr Ala
            420                 425                 430         
Val Thr Ala Glu Val Asp Leu Phe Gly Asp Ala Phe Ala Ala Ser Pro
        435                 440                 445             
Gly Glu Ala Pro Ala Ala Ser Glu Gly Ala Ala Ala Pro Ala Thr Pro
    450                 455                 460                 
Thr Pro Val Ala Ala Ala Leu Asp Ala Cys Ser Gly Asn Asp Pro Phe
465                 470                 475                 480 
Ala Pro Ser Glu Gly Ser Ala Glu Ala Ala Pro Glu Leu Asp Leu Phe
                485                 490                 495     
Ala Met Lys Pro Pro Glu Thr Ser Val Pro Val Val Thr Pro Thr Ala
            500                 505                 510         
Ser Thr Ala Pro Pro Val Pro Ala Thr Ala Pro Ser Pro Ala Pro Ala
        515                 520                 525             
Val Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Thr Ala Ala Ala Thr
    530                 535                 540                 
Thr Thr Thr Thr Thr Ser Ala Ala Thr Ala Thr Thr Ala Pro Pro Ala
545                 550                 555                 560 
Leu Asp Ile Phe Gly Asp Leu Phe Glu Ser Thr Pro Glu Val Ala Ala
                565                 570                 575     
Ala Pro Lys Pro Asp Ala Ala Pro Ser Ile Asp Leu Phe Ser Thr Asp
            580                 585                 590         
Ala Phe Ser Ser Pro Pro Gln Gly Ala Ser Pro Val Pro Glu Ser Ser
        595                 600                 605             
Leu Thr Ala Asp Leu Leu Ser Val Asp Ala Phe Ala Ala Pro Ser Pro
    610                 615                 620                 
Ala Thr Thr Ala Ser Pro Ala Lys Val Asp Ser Ser Gly Val Ile Asp
625                 630                 635                 640 
Leu Phe Gly Asp Ala Phe Gly Ser Ser Ala Ser Glu Pro Gln Pro Ala
                645                 650                 655     
Ser Gln Ala Ala Ser Ser Ser Ser Ala Ser Ala Asp Leu Leu Ala Gly
            660                 665                 670         
Phe Gly Gly Ser Phe Met Ala Pro Ser Pro Ser Pro Val Thr Pro Ala
        675                 680                 685             
Gln Asn Asn Leu Leu Gln Pro Asn Phe Glu Ala Ala Phe Gly Thr Thr
    690                 695                 700                 
Pro Ser Thr Ser Ser Ser Ser Ser Phe Asp Pro Ser Val Phe Asp Gly
705                 710                 715                 720 
Leu Gly Asp Leu Leu Met Pro Thr Met Ala Pro Ala Gly Gln Pro Ala
                725                 730                 735     
Pro Val Ser Met Val Pro Pro Ser Pro Ala Met Ala Ala Ser Lys Ala
            740                 745                 750         
Leu Gly Ser Asp Leu Asp Ser Ser Leu Ala Ser Leu Val Gly Asn Leu
        755                 760                 765             
Gly Ile Ser Gly Thr Thr Thr Lys Lys Gly Asp Leu Gln Trp Asn Ala
    770                 775                 780                 
Gly Glu Lys Lys Leu Thr Gly Gly Ala Asn Trp Gln Pro Lys Val Ala
785                 790                 795                 800 
Pro Ala Thr Trp Ser Ala Gly Val Pro Pro Ser Ala Pro Leu Gln Gly
                805                 810                 815     
Ala Val Pro Pro Thr Ser Ser Val Pro Pro Val Ala Gly Ala Pro Ser
            820                 825                 830         
Val Gly Gln Pro Gly Ala Gly Phe Gly Met Pro Pro Ala Gly Thr Gly
        835                 840                 845             
Met Pro Met Met Pro Gln Gln Pro Val Met Phe Ala Gln Pro Met Met
    850                 855                 860                 
Arg Pro Pro Phe Gly Ala Ala Ala Val Pro Gly Thr Gln Leu Ser Pro
865                 870                 875                 880 
Ser Pro Thr Pro Ala Ser Gln Ser Pro Lys Lys Pro Pro Ala Lys Asp
                885                 890                 895     
Pro Leu Ala Asp Leu Asn Ile Lys Asp Phe Leu
            900                 905         


<210> 8596
<211> 573
<212> PRT
<213> Homo sapiens

<400> 8596
Met Ser Gln Leu His Phe Tyr Arg Phe Tyr Leu Glu Phe Gly Cys Leu
 1               5                  10                  15      
Arg Lys Ala Phe Arg His Lys Phe Arg Leu Pro Pro Pro Ser Ser Asp
            20                  25                  30          
Phe Leu Ala Asp Val Val Gly Leu Gln Thr Glu Gln Arg Ala Gly Asp
        35                  40                  45              
Leu Pro Lys Thr Met Glu Gly Pro Leu Pro Ser Asn Ala Lys Ala Ala
    50                  55                  60                  
Ile Asn Leu Gln Asp Asp Pro Ile Ile Gln Lys Tyr Gly Ser Lys Lys
65                  70                  75                  80  
Val Gly Leu Thr Arg Cys Leu Leu Thr Lys Glu Glu Met Arg Thr Phe
                85                  90                  95      
His Phe Pro Leu Gln Gly Phe Pro Asp Cys Glu Asn Phe Leu Leu Thr
            100                 105                 110         
Lys Cys Asn Gly Ser Ile Ala Asp Asn Ser Pro Leu Phe Gly Leu Asp
        115                 120                 125             
Cys Glu Met Ala Arg Thr Thr Phe Asn Phe Ser Ile Gly Val Leu Gln
    130                 135                 140                 
Ala Glu Cys Leu Thr Ser Lys Gly Arg Glu Leu Thr Arg Ile Ser Leu
145                 150                 155                 160 
Val Ala Glu Gly Gly Cys Cys Val Met Asp Glu Leu Val Lys Pro Glu
                165                 170                 175     
Asn Lys Ile Leu Asp Tyr Leu Thr Ser Phe Ser Gly Ile Thr Lys Lys
            180                 185                 190         
Ile Leu Asn Pro Val Thr Thr Lys Leu Lys Asp Val Gln Arg Gln Leu
        195                 200                 205             
Lys Ala Leu Leu Pro Pro Asp Ala Val Leu Val Gly His Ser Leu Asp
    210                 215                 220                 
Leu Asp Leu Arg Ala Leu Lys Met Ile His Pro Tyr Val Ile Asp Thr
225                 230                 235                 240 
Ser Leu Leu Tyr Val Arg Glu Gln Gly Arg Arg Phe Lys Leu Lys Phe
                245                 250                 255     
Leu Ala Lys Val Ile Leu Gly Lys Asp Ile Gln Cys Pro Asp Arg Leu
            260                 265                 270         
Gly His Asp Ala Thr Glu Asp Ala Arg Thr Ile Leu Glu Leu Ala Arg
        275                 280                 285             
Tyr Phe Leu Lys His Gly Pro Lys Lys Ile Ala Glu Leu Asn Leu Glu
    290                 295                 300                 
Ala Leu Ala Asn His Gln Glu Ile Gln Ala Ala Gly Gln Glu Pro Lys
305                 310                 315                 320 
Asn Thr Ala Glu Val Leu Gln His Pro Asn Thr Ser Val Leu Glu Cys
                325                 330                 335     
Leu Asp Ser Val Gly Gln Lys Leu Leu Phe Leu Thr Arg Glu Thr Asp
            340                 345                 350         
Ala Gly Glu Leu Pro Ser Ser Arg Asn Cys Gln Thr Ile Lys Cys Leu
        355                 360                 365             
Ser Asn Lys Glu Val Gln Arg Pro Val Thr Glu Leu Thr Leu Asp Cys
    370                 375                 380                 
Asp Thr Leu Val Asn Glu Leu Glu Gly Asp Ser Glu Asn Gln Gly Ser
385                 390                 395                 400 
Ile Tyr Leu Ser Gly Val Ser Glu Thr Phe Lys Glu Gln Leu Leu Gln
                405                 410                 415     
Glu Pro Arg Leu Phe Leu Gly Leu Glu Ala Val Ile Leu Pro Lys Asp
            420                 425                 430         
Leu Lys Ser Gly Lys Gln Lys Lys Tyr Cys Phe Leu Lys Phe Lys Ser
        435                 440                 445             
Phe Gly Ser Ala Gln Gln Ala Leu Asn Ile Leu Thr Gly Lys Asp Trp
    450                 455                 460                 
Lys Leu Lys Gly Arg His Ala Leu Thr Pro Arg His Leu His Ala Trp
465                 470                 475                 480 
Leu Arg Gly Leu Pro Pro Glu Ser Thr Arg Leu Pro Gly Leu Arg Val
                485                 490                 495     
Val Pro Pro Pro Phe Glu Gln Glu Ala Leu Gln Thr Leu Lys Leu Asp
            500                 505                 510         
His Pro Lys Ile Ala Ala Trp Arg Trp Ser Arg Lys Ile Gly Lys Leu
        515                 520                 525             
Tyr Asn Ser Leu Cys Pro Gly Thr Leu Cys Leu Ile Leu Leu Pro Gly
    530                 535                 540                 
Thr Lys Ser Thr His Gly Ser Leu Ser Gly Leu Gly Leu Met Gly Ile
545                 550                 555                 560 
Lys Glu Glu Glu Glu Ser Ala Gly Pro Gly Leu Cys Ser
                565                 570             


<210> 8597
<211> 763
<212> PRT
<213> Homo sapiens

<400> 8597
Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu
 1               5                  10                  15      
Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro
            20                  25                  30          
Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys
        35                  40                  45              
Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile
    50                  55                  60                  
Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn
65                  70                  75                  80  
Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys
                85                  90                  95      
Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly
            100                 105                 110         
Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser
        115                 120                 125             
Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys
    130                 135                 140                 
Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys
145                 150                 155                 160 
Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr
                165                 170                 175     
Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser
            180                 185                 190         
Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu
        195                 200                 205             
Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg
    210                 215                 220                 
Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser
225                 230                 235                 240 
Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg
                245                 250                 255     
Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr
            260                 265                 270         
Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn
        275                 280                 285             
Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys
    290                 295                 300                 
Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu
305                 310                 315                 320 
Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu
                325                 330                 335     
His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn
            340                 345                 350         
Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys
        355                 360                 365             
Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro
    370                 375                 380                 
Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro
385                 390                 395                 400 
Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg
                405                 410                 415     
Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro
            420                 425                 430         
Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu
        435                 440                 445             
Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile
    450                 455                 460                 
Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu
465                 470                 475                 480 
Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu
                485                 490                 495     
Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg
            500                 505                 510         
Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser
        515                 520                 525             
Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser
    530                 535                 540                 
Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu
545                 550                 555                 560 
Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro
                565                 570                 575     
Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln
            580                 585                 590         
Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile
        595                 600                 605             
Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp
    610                 615                 620                 
Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val
625                 630                 635                 640 
Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu
                645                 650                 655     
Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser
            660                 665                 670         
Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro
        675                 680                 685             
Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser
    690                 695                 700                 
Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu
705                 710                 715                 720 
Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu
                725                 730                 735     
Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn
            740                 745                 750         
Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln
        755                 760             


<210> 8598
<211> 800
<212> PRT
<213> Homo sapiens

<400> 8598
Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu
 1               5                  10                  15      
Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro
            20                  25                  30          
Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys
        35                  40                  45              
Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile
    50                  55                  60                  
Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn
65                  70                  75                  80  
Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys
                85                  90                  95      
Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly
            100                 105                 110         
Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser
        115                 120                 125             
Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys
    130                 135                 140                 
Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys
145                 150                 155                 160 
Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr
                165                 170                 175     
Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser
            180                 185                 190         
Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu
        195                 200                 205             
Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg
    210                 215                 220                 
Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser
225                 230                 235                 240 
Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg
                245                 250                 255     
Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr
            260                 265                 270         
Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn
        275                 280                 285             
Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys
    290                 295                 300                 
Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu
305                 310                 315                 320 
Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu
                325                 330                 335     
His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn
            340                 345                 350         
Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys
        355                 360                 365             
Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro
    370                 375                 380                 
Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro
385                 390                 395                 400 
Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg
                405                 410                 415     
Val Arg Ile Ala Pro Lys Phe Gly Glu Gln Val Val Phe Gly Tyr Met
            420                 425                 430         
Ser Lys Phe Phe Ser Gly Asp Leu Arg Asp Phe Gly Thr Pro Ile Thr
        435                 440                 445             
Ser Leu Phe Asn Phe Ile Phe Leu Cys Leu Ser Val Leu Leu Ala Glu
    450                 455                 460                 
Glu Gly Ile Ala Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys
465                 470                 475                 480 
Leu Leu Phe Gly Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile
                485                 490                 495     
Lys Glu Glu Glu Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg
            500                 505                 510         
Pro Ile Lys Val Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala
        515                 520                 525             
Pro Ser Phe Lys Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln
    530                 535                 540                 
Ser Pro Thr Pro Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro
545                 550                 555                 560 
Thr Arg Cys Val Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg
                565                 570                 575     
Glu Arg Ser Arg Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val
            580                 585                 590         
Asp Glu Pro Glu Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp
        595                 600                 605             
Ala Ala Glu Leu Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln
    610                 615                 620                 
Leu Ser Tyr Ser Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys
625                 630                 635                 640 
Glu Thr Leu Pro Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg
                645                 650                 655     
Thr Pro Glu Ser Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu
            660                 665                 670         
Asp Phe Ser Pro Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro
        675                 680                 685             
Asp Pro Leu Gly Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala
    690                 695                 700                 
Pro Pro Leu Glu Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp
705                 710                 715                 720 
Leu Ile Ser Val Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val
                725                 730                 735     
Pro Lys Pro Gly Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn
            740                 745                 750         
Arg Ser Leu Thr Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu
        755                 760                 765             
Ser Lys Ile Leu Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro
    770                 775                 780                 
Leu Gly Pro Asp Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln
785                 790                 795                 800 


<210> 8599
<211> 748
<212> PRT
<213> Homo sapiens

<400> 8599
Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu
 1               5                  10                  15      
Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro
            20                  25                  30          
Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys
        35                  40                  45              
Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile
    50                  55                  60                  
Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn
65                  70                  75                  80  
Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys
                85                  90                  95      
Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly
            100                 105                 110         
Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser
        115                 120                 125             
Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys
    130                 135                 140                 
Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys
145                 150                 155                 160 
Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr
                165                 170                 175     
Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser
            180                 185                 190         
Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu
        195                 200                 205             
Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg
    210                 215                 220                 
Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser
225                 230                 235                 240 
Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg
                245                 250                 255     
Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr
            260                 265                 270         
Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn
        275                 280                 285             
Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys
    290                 295                 300                 
Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu
305                 310                 315                 320 
Asp Gln Val Phe Lys Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg
                325                 330                 335     
Asn Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met
            340                 345                 350         
Lys Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe
        355                 360                 365             
Pro Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu
    370                 375                 380                 
Pro Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys
385                 390                 395                 400 
Arg Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala
                405                 410                 415     
Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly
            420                 425                 430         
Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu
        435                 440                 445             
Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val
    450                 455                 460                 
Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys
465                 470                 475                 480 
Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro
                485                 490                 495     
Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val
            500                 505                 510         
Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg
        515                 520                 525             
Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu
    530                 535                 540                 
Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu
545                 550                 555                 560 
Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser
                565                 570                 575     
Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro
            580                 585                 590         
Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser
        595                 600                 605             
Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro
    610                 615                 620                 
Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly
625                 630                 635                 640 
Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu
                645                 650                 655     
Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val
            660                 665                 670         
Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly
        675                 680                 685             
Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr
    690                 695                 700                 
Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu
705                 710                 715                 720 
Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp
                725                 730                 735     
Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln
            740                 745             


<210> 8600
<211> 509
<212> PRT
<213> Homo sapiens

<400> 8600
Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His
 1               5                  10                  15      
Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu
            20                  25                  30          
Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly
        35                  40                  45              
Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly
    50                  55                  60                  
Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys
65                  70                  75                  80  
Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His
                85                  90                  95      
Tyr Tyr His Met Ala His Gly Thr Asp Phe Ala Ser Arg Gly Ile Glu
            100                 105                 110         
Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser
        115                 120                 125             
Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln
    130                 135                 140                 
Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn
145                 150                 155                 160 
Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr
                165                 170                 175     
Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly
            180                 185                 190         
Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser
        195                 200                 205             
Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile
    210                 215                 220                 
Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr
225                 230                 235                 240 
Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu
                245                 250                 255     
Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe
            260                 265                 270         
Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys
        275                 280                 285             
Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile
    290                 295                 300                 
Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys
305                 310                 315                 320 
Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg
                325                 330                 335     
Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala
            340                 345                 350         
Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp
        355                 360                 365             
Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile
    370                 375                 380                 
Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala
385                 390                 395                 400 
Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr
                405                 410                 415     
Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn
            420                 425                 430         
Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp
        435                 440                 445             
Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val
    450                 455                 460                 
Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile
465                 470                 475                 480 
Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu
                485                 490                 495     
Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe
            500                 505                 


<210> 8601
<211> 505
<212> PRT
<213> Homo sapiens

<400> 8601
Met Ser Asp Lys Asp Asp Ile Glu Thr Pro Leu Leu Thr Glu Ala Ala
 1               5                  10                  15      
Pro Ile Leu Glu Asp Gly Asn Cys Glu Pro Ala Lys Asn Ser Glu Ser
            20                  25                  30          
Val Asp Gln Gly Ala Lys Pro Glu Ser Lys Ser Glu Pro Val Val Ser
        35                  40                  45              
Thr Arg Lys Arg Pro Glu Thr Lys Pro Ser Ser Asp Leu Glu Thr Ser
    50                  55                  60                  
Lys Val Leu Pro Ile Gln Asp Asn Val Ser Lys Asp Val Pro Gln Thr
65                  70                  75                  80  
Arg Trp Gly Tyr Trp Gly Ser Trp Gly Lys Ser Ile Leu Ser Ser Ala
                85                  90                  95      
Ser Ala Thr Val Ala Thr Val Gly Gln Gly Ile Ser Asn Val Ile Glu
            100                 105                 110         
Lys Ala Glu Thr Ser Leu Gly Ile Pro Ser Pro Ser Glu Ile Ser Thr
        115                 120                 125             
Glu Val Lys Tyr Val Ala Gly Glu Thr Asn Ala Lys Glu Asn Glu Asn
    130                 135                 140                 
Ser Ser Pro Val Ala Gly Ala Phe Gly Val Phe Ser Thr Ile Ser Thr
145                 150                 155                 160 
Ala Val Gln Ser Thr Gly Lys Ser Val Ile Ser Gly Gly Leu Asp Ala
                165                 170                 175     
Leu Glu Phe Ile Gly Lys Lys Thr Met Asp Val Ile Ala Glu Gly Asp
            180                 185                 190         
Pro Gly Phe Lys Arg Thr Lys Gly Leu Met Asn Arg Asn Ala Thr Leu
        195                 200                 205             
Ser Gln Val Leu Arg Glu Ala Lys Glu Lys Glu Glu Ile Arg Thr Ser
    210                 215                 220                 
Asn Glu Val Thr Val Glu Thr Asp Lys Lys Thr His Tyr Gly Leu Leu
225                 230                 235                 240 
Phe Asp Glu Phe Gln Gly Leu Ser His Leu Glu Ala Leu Glu Met Leu
                245                 250                 255     
Ser Gln Glu Ser Glu Ile Lys Val Lys Ser Ile Leu Asn Ser Leu Ser
            260                 265                 270         
Gly Glu Glu Leu Glu Thr Leu Lys Val Glu Leu Glu Gln Leu Lys Glu
        275                 280                 285             
Thr Phe Ser Leu Ala Glu Phe Cys Glu Glu Glu Glu Glu Glu Lys Lys
    290                 295                 300                 
Gly Asp Glu Asp Phe Thr Lys Asp Ile Thr Glu Leu Phe Ser Gln Leu
305                 310                 315                 320 
His Val Ser Ser Lys Pro Glu Lys Leu Ala Arg Ala Arg Asn Thr Ala
                325                 330                 335     
His Glu Trp Ile Arg Lys Ser Leu Thr Lys Pro Leu Ala Glu Asn Glu
            340                 345                 350         
Glu Gly Glu Lys Gln Ser Glu Ala Glu Asn Thr Glu Gln Val Asn Lys
        355                 360                 365             
Asn Ser Ile Glu Asp Ile His Ala Phe Ala Ile Arg Ser Leu Ala Glu
    370                 375                 380                 
Leu Thr Ala Cys Ser Ile Glu Leu Phe His Lys Thr Ala Ala Leu Val
385                 390                 395                 400 
Leu His Gly Arg Lys Gln Glu Val Thr Ala Ile Glu Arg Ser Gln Thr
                405                 410                 415     
Leu Ser Gln Met Thr Ile Val Leu Cys Lys Glu Leu Ser Ser Leu Ser
            420                 425                 430         
Lys Glu Phe Thr Thr Cys Leu Thr Thr Ala Gly Val Lys Glu Met Ala
        435                 440                 445             
Asp Val Leu Asn Pro Leu Ile Thr Ala Val Phe Leu Glu Ala Ser Asn
    450                 455                 460                 
Ser Ala Ser Tyr Ile Gln Asp Ala Phe Gln Leu Leu Leu Pro Val Leu
465                 470                 475                 480 
Glu Ile Ser Leu Ile Glu Asn Lys Ile Glu Ser His Arg His Glu Leu
                485                 490                 495     
Gln Gly Gln Lys Pro Leu Leu Glu His
            500                 505 


<210> 8602
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 8602
Met Asp Glu Cys Gly Ser Arg Ile Arg Arg Arg Val Ser Leu Pro Lys
 1               5                  10                  15      
Arg Asn Arg Pro Ser Leu Gly Cys Ile Phe Gly Ala Pro Thr Ala Ala
            20                  25                  30          
Glu Leu Glu Pro Gly Asp Glu Gly Lys Glu Glu Glu Glu Met Val Ala
        35                  40                  45              
Glu Asn Arg Arg Arg Lys Thr Ala Gly Val Leu Pro Val Glu Val Gln
    50                  55                  60                  
Pro Leu Leu Leu Ser Asp Ser Pro Glu Cys Leu Val Leu Gly Gly Gly
65                  70                  75                  80  
Asp Thr Asn Pro Asp Leu Leu Arg His Met Pro Thr Asp Arg Gly Val
                85                  90                  95      
Gly Asp Gln Pro Asn Asp Ser Glu Val Asp Met Phe Gly Asp Tyr Asp
            100                 105                 110         
Ser Phe Thr Glu Asn Ser Phe Ile Ala Gln Val Asp Asp Leu Glu Gln
        115                 120                 125             
Lys Tyr Met Gln Leu Pro Glu His Lys Lys His Ala Thr Asp Phe Ala
    130                 135                 140                 
Thr Glu Asn Leu Cys Ser Glu Ser Ile Lys Asn Lys Leu Ser Ile Thr
145                 150                 155                 160 
Thr Ile Gly Asn Leu Thr Glu Leu Gln Thr Asp Lys His Thr Glu Asn
                165                 170                 175     
Gln Ser Gly Tyr Glu Gly Val Thr Ile Glu Pro Gly Ala Asp Leu Leu
            180                 185                 190         
Tyr Asp Val Pro Ser Ser Gln Ala Ile Tyr Phe Glu Asn Leu Gln Asn
        195                 200                 205             
Ser Ser Asn Asp Leu Gly Asp His Ser Met Lys Glu Arg Asp Trp Lys
    210                 215                 220                 
Ser Ser Ser His Asn Thr Val Asn Glu Glu Leu Pro His Asn Cys Ile
225                 230                 235                 240 
Glu Gln Pro Gln Gln Asn Asp Glu Ser Ser Ser Lys Val Arg Thr Ser
                245                 250                 255     
Ser Asp Met Asn Arg Arg Lys Ser Ile Lys Asp His Leu Lys Asn Ala
            260                 265                 270         
Met Thr Gly Asn Ala Lys Ala Gln Thr Pro Ile Phe Ser Arg Ser Lys
        275                 280                 285             
Gln Leu Lys Asp Thr Leu Leu Ser Glu Glu Ile Asn Val Ala Lys Lys
    290                 295                 300                 
Thr Ile Glu Ser Ser Ser Asn Asp Leu Gly Pro Phe Tyr Ser Leu Pro
305                 310                 315                 320 
Ser Lys Val Arg Asp Leu Tyr Ala Gln Phe Lys Gly Ile Glu Lys Leu
                325                 330                 335     
Tyr Glu Trp Gln His Thr Cys Leu Thr Leu Asn Ser Val Gln Glu Arg
            340                 345                 350         
Lys Asn Leu Ile Tyr Ser Leu Pro Thr Ser Gly Gly Lys Thr Leu Val
        355                 360                 365             
Ala Glu Ile Leu Met Leu Gln Glu Leu Leu Cys Cys Arg Lys Asp Val
    370                 375                 380                 
Leu Met Ile Leu Pro Tyr Val Ala Ile Val Gln Glu Lys Ile Ser Gly
385                 390                 395                 400 
Leu Ser Ser Phe Gly Ile Glu Leu Gly Phe Phe Val Glu Glu Tyr Ala
                405                 410                 415     
Gly Ser Lys Gly Arg Phe Pro Pro Thr Lys Arg Arg Glu Lys Lys Ser
            420                 425                 430         
Leu Tyr Ile Ala Thr Ile Glu Lys Gly His Ser Leu Val Asn Ser Leu
        435                 440                 445             
Ile Glu Thr Gly Arg Ile Asp Ser Leu Gly Leu Val Val Val Asp Glu
    450                 455                 460                 
Leu His Met Ile Gly Glu Gly Ser Arg Gly Ala Thr Leu Glu Met Thr
465                 470                 475                 480 
Leu Ala Lys Ile Leu Tyr Thr Ser Lys Thr Thr Gln Ile Ile Gly Met
                485                 490                 495     
Ser Ala Thr Leu Asn Asn Val Glu Asp Leu Gln Lys Phe Leu Gln Ala
            500                 505                 510         
Glu Tyr Tyr Thr Ser Gln Phe Arg Pro Val Glu Leu Lys Glu Tyr Leu
        515                 520                 525             
Lys Ile Asn Asp Thr Ile Tyr Glu Val Asp Ser Lys Ala Glu Asn Gly
    530                 535                 540                 
Met Thr Phe Ser Arg Leu Leu Asn Tyr Lys Tyr Ser Asp Thr Leu Lys
545                 550                 555                 560 
Lys Met Asp Pro Asp His Leu Val Ala Leu Val Thr Glu Val Ile Pro
                565                 570                 575     
Asn Tyr Ser Cys Leu Val Phe Cys Pro Ser Lys Lys Asn Cys Glu Asn
            580                 585                 590         
Val Ala Glu Met Ile Cys Lys Phe Leu Ser Lys Glu Tyr Leu Lys His
        595                 600                 605             
Lys Glu Lys Glu Lys Cys Glu Val Ile Lys Asn Leu Lys Asn Ile Gly
    610                 615                 620                 
Asn Gly Asn Leu Cys Pro Val Leu Lys Arg Thr Ile Pro Phe Gly Val
625                 630                 635                 640 
Ala Tyr His His Ser Gly Leu Thr Ser Asp Glu Arg Lys Leu Leu Glu
                645                 650                 655     
Glu Ala Tyr Ser Thr Gly Val Leu Cys Leu Phe Thr Cys Thr Ser Thr
            660                 665                 670         
Leu Ala Ala Gly Val Asn Leu Pro Ala Arg Arg Val Ile Leu Arg Ala
        675                 680                 685             
Pro Tyr Val Ala Lys Glu Phe Leu Lys Arg Asn Gln Tyr Lys Gln Met
    690                 695                 700                 
Ile Gly Arg Ala Gly Arg Ala Gly Ile Asp Thr Ile Gly Glu Ser Ile
705                 710                 715                 720 
Leu Ile Leu Gln Glu Lys Asp Lys Gln Gln Val Leu Glu Leu Ile Thr
                725                 730                 735     
Lys Pro Leu Glu Asn Cys Tyr Ser His Leu Val Gln Glu Phe Thr Lys
            740                 745                 750         
Gly Ile Gln Thr Leu Phe Leu Ser Leu Ile Gly Leu Lys Ile Ala Thr
        755                 760                 765             
Asn Leu Asp Asp Ile Tyr His Phe Met Asn Gly Thr Phe Phe Gly Val
    770                 775                 780                 
Gln Gln Lys Val Leu Leu Lys Glu Lys Ser Leu Trp Glu Ile Thr Val
785                 790                 795                 800 
Glu Ser Leu Arg Tyr Leu Thr Glu Lys Gly Leu Leu Gln Lys Asp Thr
                805                 810                 815     
Ile Tyr Lys Ser Glu Glu Glu Val Gln Tyr Asn Phe His Ile Thr Lys
            820                 825                 830         
Leu Gly Arg Ala Ser Phe Lys Gly Thr Ile Asp Leu Ala Tyr Cys Asp
        835                 840                 845             
Ile Leu Tyr Arg Asp Leu Lys Lys Gly Leu Glu Gly Leu Val Leu Glu
    850                 855                 860                 
Ser Leu Leu His Leu Ile Tyr Leu Thr Thr Pro Tyr Asp Leu Val Ser
865                 870                 875                 880 
Gln Cys Asn Pro Asp Trp Met Ile Tyr Phe Arg Gln Phe Ser Gln Leu
                885                 890                 895     
Ser Pro Ala Glu Gln Asn Val Ala Ala Ile Leu Gly Val Ser Glu Ser
            900                 905                 910         
Phe Ile Gly Lys Lys Ala Ser Gly Gln Ala Ile Gly Lys Lys Val Asp
        915                 920                 925             
Lys Asn Val Val Asn Arg Leu Tyr Leu Ser Phe Val Leu Tyr Thr Leu
    930                 935                 940                 
Leu Lys Glu Thr Asn Ile Trp Thr Val Ser Glu Lys Phe Asn Met Pro
945                 950                 955                 960 
Arg Gly Tyr Ile Gln Asn Leu Leu Thr Gly Thr Ala Ser Phe Ser Ser
                965                 970                 975     
Cys Val Leu His Phe Cys Glu Glu Leu Glu Glu Phe Trp Val Tyr Arg
            980                 985                 990         
Ala Leu Leu Val Glu Leu Thr Lys Lys Leu Thr Tyr Cys Val Lys Ala
        995                 1000                1005            
Glu Leu Ile Pro Leu Met Glu Val Thr Gly Val Leu Glu Gly Arg Ala
    1010                1015                1020                
Lys Gln Leu Tyr Ser Ala Gly Tyr Lys Ser Leu Met His Leu Ala Asn
1025                1030                1035                1040
Ala Asn Pro Glu Val Leu Val Arg Thr Ile Asp His Leu Ser Arg Arg
                1045                1050                1055    
Gln Ala Lys Gln Ile Val Ser Ser Ala Lys Met Leu Leu His Glu Lys
            1060                1065                1070        
Ala Glu Ala Leu Gln Glu Glu Val Glu Glu Leu Leu Arg Leu Pro Ser
        1075                1080                1085            
Asp Phe Pro Gly Ala Val Ala Ser Ser Thr Asp Lys Ala
    1090                1095                1100    


<210> 8603
<211> 629
<212> PRT
<213> Homo sapiens

<400> 8603
Met Glu Gln Gly His Ser Asp Leu Glu Lys Met Gln Asp Leu Tyr Ser
 1               5                  10                  15      
Glu Ser Leu Ile Met Asp Trp Trp Tyr Asn Ala Glu Lys Asp Gly Asp
            20                  25                  30          
Ser Lys His Gln Lys Glu Ile Cys Ser Met Ile Ser Thr Pro Glu Lys
        35                  40                  45              
Cys Ala Lys Pro Gln Ser Asp Val Asp Ser Thr Gln Thr Ser Ser Leu
    50                  55                  60                  
Asn Met Leu Lys Gly Pro Trp Gly Leu Ser Asp Gln Lys Val Gln Lys
65                  70                  75                  80  
Lys Lys Val Leu His Ala Glu Ser Thr Lys Thr Ser Leu Leu Arg Ser
                85                  90                  95      
Gln Met Ser Ser Leu Arg Ser Ser Ala Cys Ser Glu Arg Lys Asp Gly
            100                 105                 110         
Leu Ser Asn Ala Ser Ser Arg Arg Thr Ala Leu Ser Asp Lys Glu Met
        115                 120                 125             
Ser Ile Leu Leu Ala Glu Glu Trp Leu Asp Asp Lys Ser Ser Glu Lys
    130                 135                 140                 
Val Thr Arg Glu Gly Ser Gln Val Tyr Asp His Asp Ser Ser Asp Val
145                 150                 155                 160 
Ser Ser Glu Asn Trp Leu Lys Thr Tyr Gly Leu Val Ala Lys Lys Leu
                165                 170                 175     
Thr Leu Met Asp Ala Leu Ser Val Ala Ala Val Pro His Ser Ser Thr
            180                 185                 190         
Tyr Val Pro Val Leu Asp Lys His Val Met Ser Lys Val Phe Asp Glu
        195                 200                 205             
Val Phe Pro Leu Ala His Val Cys Asn Asp Thr Asn Lys Met Thr Leu
    210                 215                 220                 
Ile Asn Pro Gln Gly Ala Lys Leu Asn Ile Tyr Lys Arg Lys Val Glu
225                 230                 235                 240 
Gln Ala Ile Gln Ser Tyr Glu Lys Arg Leu Asn Lys Ile Val Trp Arg
                245                 250                 255     
Ala Leu Ser Gln Glu Glu Lys Glu Lys Leu Asp Ala Asn Lys Pro Ile
            260                 265                 270         
Gln Tyr Leu Glu Asn Lys Thr Val Leu Asn Gln Ala Leu Glu Arg Leu
        275                 280                 285             
Asn Trp Pro Ile Ser Leu Lys Glu Leu Ser Met Leu Glu Ser Glu Ile
    290                 295                 300                 
Leu Ala Gly Lys Met Tyr Ile Gln Gln Ala Met Glu Leu Gln Glu Ala
305                 310                 315                 320 
Ala Lys Lys Asn Tyr Ala Asn Lys Ala Pro Gly Glu Gln Gln Lys Leu
                325                 330                 335     
Gln Gly Asn Pro Thr Lys Lys Thr Lys Ser Lys Arg Pro Asp Pro Leu
            340                 345                 350         
Lys Gly Gln Lys Val Ile Ala Arg Cys Asp Glu Asn Gly Phe Tyr Phe
        355                 360                 365             
Pro Gly Val Val Lys Lys Cys Val Ser Arg Thr Gln Ala Leu Val Gly
    370                 375                 380                 
Phe Ser Tyr Gly Asp Thr Lys Val Val Ser Thr Ser Phe Ile Thr Pro
385                 390                 395                 400 
Val Gly Gly Ala Met Pro Cys Pro Leu Leu Gln Val Gly Asp Tyr Val
                405                 410                 415     
Phe Ala Lys Ile Val Ile Pro Lys Gly Phe Asp Phe Tyr Val Pro Ala
            420                 425                 430         
Ile Val Ile Ala Leu Pro Asn Lys His Val Ala Thr Glu Lys Phe Tyr
        435                 440                 445             
Thr Val Leu Lys Cys Asn Asn Arg Arg Glu Phe Cys Pro Arg Ser Ala
    450                 455                 460                 
Leu Ile Lys Ile Ser Gln Asn Lys Tyr Ala Leu Ser Cys Ser His Ile
465                 470                 475                 480 
Lys Ser Pro Pro Ile Pro Glu Asp Pro Glu Val Glu Asp Val Glu Ala
                485                 490                 495     
Arg Asn Ser Ala Phe Leu Phe Trp Pro Leu Lys Glu Ala Asp Thr Gln
            500                 505                 510         
Asp Ser Arg Glu Pro Arg Arg Glu Lys Pro Arg Arg Lys Lys Arg Pro
        515                 520                 525             
Ala Lys Gln Pro Leu Gln Gln Ala Ala Pro Ser Asp Ser Asp Gly Ser
    530                 535                 540                 
Ser His Gly Ile Ser Ser His Gly Ser Cys Gln Gly Thr His Pro Glu
545                 550                 555                 560 
Pro Lys Val Trp Val Met Gly Gly Glu His Asn Ile Ala Tyr Leu Arg
                565                 570                 575     
Asn Thr Leu Lys Ser Leu Ser Arg Ile Val His Leu Thr Ser Ser Phe
            580                 585                 590         
Arg Phe Trp Ala Cys Leu Gly Ser Ser Ala Ala Lys Thr Leu Thr Ser
        595                 600                 605             
Leu Ser Asn Ala Glu Leu Cys Phe Pro Arg Gln Pro Thr Ser Thr Ser
    610                 615                 620                 
Pro Arg Pro Gly Val
625                 


<210> 8604
<211> 686
<212> PRT
<213> Homo sapiens

<400> 8604
Met Cys Ile Ile Pro Pro Glu Thr Val Ile Asp Gln Val Lys Arg Phe
 1               5                  10                  15      
Gln Glu Ile Pro Ile Tyr Thr Ile Ser Phe Asn Tyr Asn Asp Glu Ile
            20                  25                  30          
Ala Asn Arg Phe Leu Lys Glu Val Ala Ala Leu Thr Gly Gly Glu Phe
        35                  40                  45              
His Phe Tyr Asn Phe Gly Cys Lys Asp Pro Thr Pro Pro Glu Ala Val
    50                  55                  60                  
Gln Asn Glu Asp Val Thr Leu Leu Val Lys Glu Met Glu Gln Gly His
65                  70                  75                  80  
Ser Asp Leu Glu Lys Met Gln Asp Leu Tyr Ser Glu Ser Leu Ile Met
                85                  90                  95      
Asp Trp Trp Tyr Asn Ala Glu Lys Asp Gly Asp Ser Lys His Gln Lys
            100                 105                 110         
Glu Ile Cys Ser Met Ile Ser Thr Pro Glu Lys Cys Ala Lys Pro Gln
        115                 120                 125             
Ser Asp Val Asp Ser Thr Gln Thr Ser Ser Leu Asn Met Leu Lys Gly
    130                 135                 140                 
Pro Trp Gly Leu Ser Asp Gln Lys Val Gln Lys Lys Lys Val Leu His
145                 150                 155                 160 
Ala Glu Ser Thr Lys Thr Ser Leu Leu Arg Ser Gln Met Ser Ser Leu
                165                 170                 175     
Arg Ser Ser Ala Cys Ser Glu Arg Lys Asp Gly Leu Ser Asn Ala Ser
            180                 185                 190         
Ser Arg Arg Thr Ala Leu Ser Asp Lys Glu Met Ser Ile Leu Leu Ala
        195                 200                 205             
Glu Glu Trp Leu Asp Asp Lys Ser Ser Glu Lys Val Thr Arg Glu Gly
    210                 215                 220                 
Ser Gln Val Tyr Asp His Asp Ser Ser Asp Val Ser Ser Glu Asn Trp
225                 230                 235                 240 
Leu Lys Thr Tyr Gly Leu Val Ala Lys Lys Leu Thr Leu Met Asp Ala
                245                 250                 255     
Leu Ser Val Ala Ala Val Pro His Ser Ser Thr Tyr Val Pro Val Leu
            260                 265                 270         
Asp Lys His Val Met Ser Lys Val Phe Asp Glu Val Phe Pro Leu Ala
        275                 280                 285             
His Val Cys Asn Asp Thr Asn Lys Met Thr Leu Ile Asn Pro Gln Gly
    290                 295                 300                 
Ala Lys Leu Asn Ile Tyr Lys Arg Lys Val Glu Gln Ala Ile Gln Ser
305                 310                 315                 320 
Tyr Glu Lys Arg Leu Asn Lys Ile Val Trp Arg Ala Leu Ser Gln Glu
                325                 330                 335     
Glu Lys Glu Lys Leu Asp Ala Asn Lys Pro Ile Gln Tyr Leu Glu Asn
            340                 345                 350         
Lys Thr Val Leu Asn Gln Ala Leu Glu Arg Leu Asn Trp Pro Ile Ser
        355                 360                 365             
Leu Lys Glu Leu Ser Met Leu Glu Ser Glu Ile Leu Ala Gly Lys Met
    370                 375                 380                 
Tyr Ile Gln Gln Ala Met Glu Leu Gln Glu Ala Ala Lys Lys Asn Tyr
385                 390                 395                 400 
Ala Asn Lys Ala Pro Gly Glu Gln Gln Lys Leu Gln Gly Asn Pro Thr
                405                 410                 415     
Lys Lys Thr Lys Ser Lys Arg Pro Asp Pro Leu Lys Gly Gln Lys Val
            420                 425                 430         
Ile Ala Arg Cys Asp Glu Asn Gly Phe Tyr Phe Pro Gly Val Val Lys
        435                 440                 445             
Lys Cys Val Ser Arg Thr Gln Ala Leu Val Gly Phe Ser Tyr Gly Asp
    450                 455                 460                 
Thr Lys Val Val Ser Thr Ser Phe Ile Thr Pro Val Gly Gly Ala Met
465                 470                 475                 480 
Pro Cys Pro Leu Leu Gln Val Gly Asp Tyr Val Phe Ala Lys Ile Val
                485                 490                 495     
Ile Pro Lys Gly Phe Asp Phe Tyr Val Pro Ala Ile Val Ile Ala Leu
            500                 505                 510         
Pro Asn Lys His Val Ala Thr Glu Lys Phe Tyr Thr Val Leu Lys Cys
        515                 520                 525             
Asn Asn Arg Arg Glu Phe Cys Pro Arg Ser Ala Leu Ile Lys Ile Ser
    530                 535                 540                 
Gln Asn Lys Tyr Ala Leu Ser Cys Ser His Ile Lys Ser Pro Pro Ile
545                 550                 555                 560 
Pro Glu Asp Pro Glu Val Glu Asp Val Glu Ala Arg Asn Ser Ala Phe
                565                 570                 575     
Leu Phe Trp Pro Leu Lys Glu Ala Asp Thr Gln Asp Ser Arg Glu Pro
            580                 585                 590         
Arg Arg Glu Lys Pro Arg Arg Lys Lys Arg Pro Ala Lys Gln Pro Leu
        595                 600                 605             
Gln Gln Ala Ala Pro Ser Asp Ser Asp Gly Ser Ser His Gly Ile Ser
    610                 615                 620                 
Ser His Gly Ser Cys Gln Gly Thr His Pro Glu Pro Lys Thr Ala His
625                 630                 635                 640 
Leu His Phe Pro Ala Ala Gly Arg Leu Gly Leu Ser Ser His Ala Ile
                645                 650                 655     
Ile Ala Thr Pro Pro Pro Arg Ala Ala Leu Pro Cys Thr Leu Gln Ala
            660                 665                 670         
Thr His Ser Ser Lys Gly Leu Arg Ser Val Pro Glu Thr Leu
        675                 680                 685     


<210> 8605
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 8605
Met Glu Lys Ser Gly Pro Ser Ser Thr Ile Ser Glu Gln Gln Leu Gln
 1               5                  10                  15      
Arg Gln Glu Gly Trp Ile Asn Thr Lys Thr Asp Leu Ala Glu Gln Ser
            20                  25                  30          
Leu Ile Ser Ser Glu Lys Trp Leu Gln Leu His Gly Leu Lys Ser Asn
        35                  40                  45              
Lys Leu Thr Leu Lys Gln Ile Leu Ser Gln Ile Gly Phe Pro His Cys
    50                  55                  60                  
Glu Asp Tyr Val Ala Ser Leu Gly Arg Pro Val Ala Ser Arg Tyr Ala
65                  70                  75                  80  
Asp Gly Leu Phe Pro Gln Leu Tyr Arg Ala Glu Asp Gly Arg Val Tyr
                85                  90                  95      
Asn Leu Thr Ala Lys Ser Glu Leu Ile Tyr Gln Phe Val Glu His Leu
            100                 105                 110         
Thr Gln Ala Val Glu Ser Tyr Lys Gln Arg Met Asp Trp Leu Thr Ser
        115                 120                 125             
Lys Ser Arg Gln Ile Phe Gly Val Ile Leu Glu Gln Cys Val Thr Ile
    130                 135                 140                 
Val Leu Asp Phe Gly Gly Ile Leu Glu Gly Glu Leu Asp Leu Cys Arg
145                 150                 155                 160 
Glu Ala Leu Thr Met Val Leu Gln Glu Gln Val Ala His Ile Thr Glu
                165                 170                 175     
Phe Asn Ile Ile Arg Val Ser Gln Glu Pro Val Lys Trp Gln Glu Asn
            180                 185                 190         
Ala Thr Pro Val Thr Glu Gln Ser Ile Ala Thr Ala Ile Ser Trp Val
        195                 200                 205             
Glu Lys Leu Thr Val Glu Leu Thr Val Ser Glu Ala Gly Arg Leu Asp
    210                 215                 220                 
Ala Leu Leu Glu Ala Gly Arg Asp Lys Thr Ile Glu Ser Ile Tyr Tyr
225                 230                 235                 240 
Phe Val Val Gly Asp Val Pro Glu Glu Ser Lys Glu Leu Leu Leu Gln
                245                 250                 255     
Arg Ala Leu Glu Ile Pro Cys Pro Val Tyr Thr Val Ser Phe Asn Ala
            260                 265                 270         
Arg Gly Glu Gly Thr Ile Ala Phe Leu Lys Asp Leu Ser Ala Lys Thr
        275                 280                 285             
His Ser Arg Phe His Ala Phe Ala Glu Arg Thr Glu Cys Val Glu Phe
    290                 295                 300                 
Pro Ala Phe Ser Thr Lys Asp Gly Asp Asn Val Met Thr Trp Asn Ser
305                 310                 315                 320 
Arg Lys Leu Lys Gly Lys Leu Pro Pro Gly Ala Gly Val Arg Glu Asp
                325                 330                 335     
Val Phe Leu Val Trp Gln Glu Met Glu Glu Ala Arg Ser Thr Leu Ala
            340                 345                 350         
Gln Ile Gln Arg Leu Val Ala Glu Pro Pro Lys Pro Asp Val Ala Thr
        355                 360                 365             
Val Asp Cys Glu Ser Glu Thr Thr Ser Val Glu Ile Ala Ser Asn Pro
    370                 375                 380                 
Glu Asp Thr Trp Asp Ser Lys Thr Trp Leu Gln Lys Tyr Gly Leu Lys
385                 390                 395                 400 
Ala Gln Lys Leu Ser Leu Tyr Asp Val Leu Ala Asp Cys Ser Phe Cys
                405                 410                 415     
His Ala Asp Gly Val Val Asp Ile Lys Ala Lys Pro Glu Asn Glu Ser
            420                 425                 430         
Val Gln Thr Ser Ala Glu Thr Asn Lys Lys Thr Val His Ala Lys Tyr
        435                 440                 445             
Cys Ser Arg Phe Val His Ala Pro Trp Lys Asp Gly Ser Leu Val His
    450                 455                 460                 
Val Asn Ile Thr Lys Glu Lys Cys Lys Trp Tyr Ser Glu Arg Ile His
465                 470                 475                 480 
Thr Ala Leu Ala Arg Ile Arg Arg Arg Ile Lys Trp Leu Gln Asp Gly
                485                 490                 495     
Ser Gln Ser Leu Phe Gly Arg Leu His Asn Asp Cys Ile Tyr Ile Leu
            500                 505                 510         
Ile Asp Thr Ser His Ser Met Lys Ser Lys Leu Asp Leu Val Lys Asp
        515                 520                 525             
Lys Ile Ile Gln Phe Ile Gln Glu Gln Leu Lys Tyr Lys Ser Lys Phe
    530                 535                 540                 
Asn Phe Val Lys Phe Asp Gly Gln Ala Val Ala Trp Arg Glu Gln Leu
545                 550                 555                 560 
Ala Glu Val Asn Glu Asp Asn Leu Glu Gln Ala Gln Ser Trp Ile Arg
                565                 570                 575     
Asp Ile Lys Ile Gly Ser Ser Thr Asn Thr Leu Ser Ala Leu Lys Thr
            580                 585                 590         
Ala Phe Ala Asp Lys Glu Thr Gln Ala Ile Tyr Leu Leu Thr Asp Gly
        595                 600                 605             
Arg Pro Asp Gln Pro Pro Glu Thr Val Ile Asp Gln Val Lys Arg Phe
    610                 615                 620                 
Gln Glu Ile Pro Ile Tyr Thr Ile Ser Phe Asn Tyr Asn Asp Glu Ile
625                 630                 635                 640 
Ala Asn Arg Phe Leu Lys Glu Val Ala Ala Leu Thr Gly Gly Glu Phe
                645                 650                 655     
His Phe Tyr Asn Phe Gly Cys Lys Asp Pro Thr Pro Pro Glu Ala Val
            660                 665                 670         
Gln Asn Glu Asp Val Thr Leu Leu Val Lys Glu Met Glu Gln Gly His
        675                 680                 685             
Ser Asp Leu Glu Lys Met Gln Asp Leu Tyr Ser Glu Ser Leu Ile Met
    690                 695                 700                 
Asp Trp Trp Tyr Asn Ala Glu Lys Asp Gly Asp Ser Lys His Gln Lys
705                 710                 715                 720 
Glu Ile Cys Ser Met Ile Ser Thr Pro Glu Arg Cys Ala Lys Pro Gln
                725                 730                 735     
Ser Asp Val Asp Ser Thr Gln Thr Ser Ser Leu Asn Met Leu Lys Gly
            740                 745                 750         
Pro Trp Gly Leu Ser Asp Gln Lys Val Gln Lys Lys Lys Val Leu His
        755                 760                 765             
Ala Glu Ser Thr Lys Thr Ser Leu Leu Arg Ser Gln Met Ser Ser Leu
    770                 775                 780                 
Arg Ser Ser Ala Cys Ser Glu Arg Lys Asp Gly Leu Ser Asn Ala Ser
785                 790                 795                 800 
Ser Arg Arg Thr Ala Leu Ser Asp Lys Glu Met Ser Ile Leu Leu Ala
                805                 810                 815     
Glu Glu Trp Leu Asp Asp Lys Ser Ser Glu Lys Val Thr Arg Glu Gly
            820                 825                 830         
Ser Gln Val Tyr Asp His Asp Ser Ser Asp Val Ser Ser Glu Asn Trp
        835                 840                 845             
Leu Lys Thr Tyr Gly Leu Val Ala Lys Lys Leu Thr Leu Met Asp Ala
    850                 855                 860                 
Leu Ser Val Ala Ala Val Pro His Ser Ser Thr Tyr Val Pro Val Leu
865                 870                 875                 880 
Asp Lys His Val Met Ser Lys Val Leu Asp Glu Val Phe Pro Leu Ala
                885                 890                 895     
His Val Cys Asn Asp Thr Asn Lys Met Thr Leu Ile Asn Pro Gln Gly
            900                 905                 910         
Ala Lys Leu Asn Ile Tyr Lys Arg Lys Val Glu Gln Ala Ile Gln Ser
        915                 920                 925             
Tyr Glu Lys Arg Leu Asn Lys Ile Val Trp Arg Ala Leu Ser Gln Glu
    930                 935                 940                 
Glu Lys Glu Lys Leu Asp Ala Asn Lys Pro Ile Gln Tyr Leu Glu Asn
945                 950                 955                 960 
Lys Thr Val Leu Asn Gln Ala Leu Glu Arg Leu Asn Trp Pro Ile Ser
                965                 970                 975     
Leu Lys Glu Leu Ser Met Leu Glu Ser Glu Ile Leu Ala Gly Lys Met
            980                 985                 990         
Tyr Ile Gln Gln Ala Met Glu Leu Gln Glu Ala Ala Lys Lys Asn Tyr
        995                 1000                1005            
Ala Asn Lys Ala Pro Gly Glu Gln Gln Lys Leu Gln Gly Asn Pro Thr
    1010                1015                1020                
Lys Lys Thr Lys Ser Lys Arg Pro Asp Pro Leu Lys Gly Gln Lys Val
1025                1030                1035                1040
Ile Ala Arg Cys Asp Glu Asn Gly Phe Tyr Phe Pro Gly Ser Phe Phe
                1045                1050                1055    
Phe Leu Ile Ser
            1060


<210> 8606
<211> 803
<212> PRT
<213> Homo sapiens

<400> 8606
Trp Leu Gln Asp Gly Ser Gln Ser Leu Phe Gly Arg Leu His Asn Asp
 1               5                  10                  15      
Cys Ile Tyr Ile Leu Ile Asp Thr Ser His Ser Met Lys Ser Lys Leu
            20                  25                  30          
Asp Leu Val Lys Asp Lys Ile Ile Gln Phe Ile Gln Glu Gln Leu Lys
        35                  40                  45              
Tyr Lys Ser Lys Phe Asn Phe Val Lys Phe Asp Gly Gln Ala Val Ala
    50                  55                  60                  
Trp Arg Glu Gln Leu Ala Glu Val Asn Glu Asp Asn Leu Glu Gln Ala
65                  70                  75                  80  
Gln Ser Trp Ile Arg Asp Ile Lys Ile Gly Ser Ser Thr Asn Thr Leu
                85                  90                  95      
Ser Ala Leu Lys Thr Ala Phe Ala Asp Lys Glu Thr Gln Ala Ile Tyr
            100                 105                 110         
Leu Leu Thr Asp Gly Arg Pro Asp Gln Pro Pro Glu Thr Val Ile Asp
        115                 120                 125             
Gln Val Lys Arg Phe Gln Glu Ile Pro Ile Tyr Thr Ile Ser Phe Asn
    130                 135                 140                 
Tyr Asn Asp Glu Ile Ala Asn Arg Phe Leu Lys Glu Val Ala Ala Leu
145                 150                 155                 160 
Thr Gly Gly Glu Phe His Phe Tyr Asn Phe Gly Cys Lys Asp Pro Thr
                165                 170                 175     
Pro Pro Glu Ala Val Gln Asn Glu Asp Leu Thr Leu Leu Val Lys Glu
            180                 185                 190         
Met Glu Gln Gly His Ser Asp Leu Glu Lys Met Gln Asp Leu Tyr Ser
        195                 200                 205             
Glu Ser Leu Ile Met Asp Trp Trp Tyr Asn Ala Glu Lys Asp Gly Asp
    210                 215                 220                 
Ser Lys His Gln Lys Glu Ile Cys Ser Met Ile Ser Thr Pro Glu Lys
225                 230                 235                 240 
Cys Ala Lys Pro Gln Ser Asp Val Asp Ser Thr Gln Thr Ser Ser Leu
                245                 250                 255     
Asn Met Leu Lys Gly Pro Trp Gly Leu Ser Asp Gln Lys Val Gln Lys
            260                 265                 270         
Lys Lys Val Leu His Ala Glu Ser Thr Lys Thr Ser Leu Leu Arg Ser
        275                 280                 285             
Gln Met Ser Ser Leu Arg Ser Ser Ala Cys Ser Glu Arg Lys Asp Gly
    290                 295                 300                 
Leu Ser Asn Ala Ser Ser Arg Arg Thr Ala Leu Ser Asp Lys Glu Met
305                 310                 315                 320 
Ser Ile Leu Leu Ala Glu Glu Trp Leu Asp Asp Lys Ser Ser Glu Lys
                325                 330                 335     
Val Thr Arg Glu Gly Ser Gln Val Tyr Asp His Asp Ser Ser Asp Val
            340                 345                 350         
Ser Ser Glu Asn Trp Leu Lys Thr Tyr Gly Leu Val Ala Lys Lys Leu
        355                 360                 365             
Thr Leu Met Asp Ala Leu Ser Val Ala Ala Val Pro His Ser Ser Thr
    370                 375                 380                 
Tyr Val Pro Val Leu Asp Lys His Val Val Ser Lys Val Phe Asp Glu
385                 390                 395                 400 
Val Phe Pro Leu Ala His Val Cys Asn Asp Thr Asn Lys Met Thr Leu
                405                 410                 415     
Ile Asn Pro Gln Gly Ala Lys Leu Asn Ile Tyr Lys Arg Lys Val Glu
            420                 425                 430         
Gln Ala Ile Gln Ser Tyr Glu Lys Arg Leu Asn Lys Ile Val Trp Arg
        435                 440                 445             
Ala Leu Ser Gln Glu Glu Lys Glu Lys Leu Asp Ala Asn Lys Pro Ile
    450                 455                 460                 
Gln Tyr Leu Glu Asn Lys Thr Val Leu Asn Gln Ala Leu Glu Arg Leu
465                 470                 475                 480 
Asn Trp Pro Ile Ser Leu Lys Glu Leu Ser Met Leu Glu Ser Glu Ile
                485                 490                 495     
Leu Ala Gly Lys Met Tyr Ile Gln Gln Ala Met Glu Leu Gln Glu Ala
            500                 505                 510         
Ala Lys Lys Asn Tyr Ala Asn Lys Ala Pro Gly Glu Gln Gln Lys Leu
        515                 520                 525             
Gln Gly Asn Pro Thr Lys Lys Thr Lys Ser Lys Arg Pro Asp Pro Leu
    530                 535                 540                 
Lys Gly Gln Lys Val Ile Ala Arg Cys Asp Glu Asn Gly Phe Tyr Phe
545                 550                 555                 560 
Pro Gly Val Val Lys Lys Cys Val Ser Arg Thr Gln Ala Leu Val Gly
                565                 570                 575     
Phe Ser Tyr Gly Asp Thr Lys Val Val Ser Thr Ser Phe Ile Thr Pro
            580                 585                 590         
Val Gly Gly Ala Met Pro Cys Pro Leu Leu Gln Val Gly Asp Tyr Val
        595                 600                 605             
Phe Ala Lys Ile Val Ile Pro Lys Gly Phe Asp Phe Tyr Val Pro Ala
    610                 615                 620                 
Ile Val Ile Ala Leu Pro Asn Lys His Val Ala Thr Glu Lys Phe Tyr
625                 630                 635                 640 
Thr Val Leu Lys Cys Asn Asn Arg Arg Glu Phe Cys Pro Arg Ser Ala
                645                 650                 655     
Leu Ile Lys Ile Ser Gln Asn Lys Tyr Ala Leu Ser Cys Ser His Ile
            660                 665                 670         
Lys Ser Pro Pro Ile Pro Glu Asp Pro Glu Val Glu Asp Val Glu Ala
        675                 680                 685             
Arg Asn Ser Ala Phe Leu Phe Trp Pro Leu Lys Glu Ala Asp Thr Gln
    690                 695                 700                 
Asp Ser Arg Glu Pro Arg Arg Glu Lys Pro Arg Arg Lys Lys Arg Pro
705                 710                 715                 720 
Ala Lys Gln Pro Leu Gln Gln Ala Ala Pro Ser Asp Ser Asp Gly Ser
                725                 730                 735     
Ser His Gly Ile Ser Ser His Gly Ser Cys Gln Gly Thr His Pro Glu
            740                 745                 750         
Pro Lys Thr Ala His Leu His Phe Pro Ala Ala Gly Arg Leu Gly Leu
        755                 760                 765             
Ser Ser His Ala Ile Ile Ala Thr Pro Pro Pro Arg Ala Ala Leu Pro
    770                 775                 780                 
Cys Thr Leu Gln Ala Thr His Ser Ser Lys Gly Leu Arg Ser Val Pro
785                 790                 795                 800 
Glu Thr Leu
            


<210> 8607
<211> 401
<212> PRT
<213> Homo sapiens

<400> 8607
Met Ala Thr Lys Gly Met Arg Leu Lys Ser Thr Lys Glu Val Phe Pro
 1               5                  10                  15      
Leu Ala His Val Cys Asn Asp Thr Asn Lys Met Thr Leu Ile Asn Pro
            20                  25                  30          
Gln Gly Ala Lys Leu Asn Ile Tyr Lys Arg Lys Val Glu Gln Ala Ile
        35                  40                  45              
Gln Ser Tyr Glu Lys Arg Leu Asn Lys Ile Val Trp Arg Ala Leu Ser
    50                  55                  60                  
Gln Glu Glu Lys Glu Lys Leu Asp Ala Asn Lys Pro Ile Gln Tyr Leu
65                  70                  75                  80  
Glu Asn Lys Thr Val Leu Asn Gln Ala Leu Glu Arg Leu Asn Trp Pro
                85                  90                  95      
Ile Ser Leu Lys Glu Leu Ser Met Leu Glu Ser Glu Ile Leu Ala Gly
            100                 105                 110         
Lys Met Tyr Ile Gln Gln Ala Met Glu Leu Gln Glu Ala Ala Lys Lys
        115                 120                 125             
Asn Tyr Ala Asn Lys Ala Pro Gly Glu Gln Gln Lys Leu Gln Gly Asn
    130                 135                 140                 
Pro Thr Lys Lys Thr Lys Ser Lys Arg Pro Asp Pro Leu Lys Gly Gln
145                 150                 155                 160 
Lys Val Ile Ala Arg Cys Asp Glu Asn Gly Phe Tyr Phe Pro Gly Val
                165                 170                 175     
Val Lys Lys Cys Val Ser Arg Thr Gln Ala Leu Val Gly Phe Ser Tyr
            180                 185                 190         
Gly Asp Thr Lys Val Val Ser Thr Ser Phe Ile Thr Pro Val Gly Gly
        195                 200                 205             
Ala Met Pro Cys Pro Leu Leu Gln Val Gly Asp Tyr Val Phe Ala Lys
    210                 215                 220                 
Ile Val Ile Pro Lys Gly Phe Asp Phe Tyr Val Pro Ala Ile Val Ile
225                 230                 235                 240 
Ala Leu Pro Asn Lys His Val Ala Thr Glu Lys Phe Tyr Thr Val Leu
                245                 250                 255     
Lys Cys Asn Asn Arg Arg Glu Phe Cys Pro Arg Ser Ala Leu Ile Lys
            260                 265                 270         
Ile Ser Gln Asn Lys Tyr Ala Leu Ser Cys Ser His Ile Lys Ser Pro
        275                 280                 285             
Pro Ile Pro Glu Asp Pro Glu Val Glu Asp Val Glu Ala Arg Asn Ser
    290                 295                 300                 
Ala Phe Leu Phe Trp Pro Leu Lys Glu Ala Asp Thr Gln Asp Ser Arg
305                 310                 315                 320 
Glu Pro Arg Arg Glu Lys Pro Arg Arg Lys Lys Arg Pro Ala Lys Gln
                325                 330                 335     
Pro Leu Gln Gln Ala Ala Pro Ser Asp Ser Asp Gly Ser Ser His Gly
            340                 345                 350         
Ile Ser Ser His Gly Pro Pro Pro Leu Pro Arg Gly Arg Ala Ser Arg
        355                 360                 365             
Thr Gln Gln Pro Arg His His Cys His Thr Ser Thr Ser Ser Ser Pro
    370                 375                 380                 
Ala Leu Tyr Ser Pro Ser His Pro Gln Gln Gln Arg Ala Glu Glu Arg
385                 390                 395                 400 
Pro
    


<210> 8608
<211> 337
<212> PRT
<213> Homo sapiens

<400> 8608
Met Ala Asp Ala Ala Pro Gln Leu Gly Lys Arg Lys Arg Glu Leu Asp
 1               5                  10                  15      
Val Glu Glu Ala His Ala Ala Ser Thr Glu Glu Lys Glu Ala Gly Val
            20                  25                  30          
Gly Asn Gly Thr Cys Ala Pro Val Arg Leu Pro Phe Ser Gly Phe Arg
        35                  40                  45              
Leu Gln Lys Val Leu Arg Glu Ser Ala Arg Asp Lys Ile Ile Phe Leu
    50                  55                  60                  
His Gly Lys Val Asn Glu Ala Ser Gly Asp Gly Asp Gly Glu Asp Ala
65                  70                  75                  80  
Val Val Ile Leu Glu Lys Thr Pro Phe Gln Val Glu Gln Val Ala Gln
                85                  90                  95      
Leu Leu Thr Gly Ser Pro Glu Leu Gln Leu Gln Phe Ser Asn Asp Ile
            100                 105                 110         
Tyr Ser Thr Tyr His Leu Phe Pro Pro Arg Gln Leu Asn Asp Val Lys
        115                 120                 125             
Thr Thr Val Val Tyr Pro Ala Thr Glu Lys His Leu Gln Lys Tyr Leu
    130                 135                 140                 
Arg Gln Asp Leu Arg Leu Ile Arg Glu Thr Gly Asp Asp Tyr Arg Asn
145                 150                 155                 160 
Ile Thr Leu Pro His Leu Glu Ser Gln Ser Leu Ser Ile Gln Trp Val
                165                 170                 175     
Tyr Asn Ile Leu Asp Lys Lys Ala Glu Ala Asp Arg Ile Val Phe Glu
            180                 185                 190         
Asn Pro Asp Pro Ser Asp Gly Phe Val Leu Ile Pro Asp Leu Lys Trp
        195                 200                 205             
Asn Gln Gln Gln Leu Asp Asp Leu Tyr Leu Ile Ala Ile Cys His Arg
    210                 215                 220                 
Arg Gly Ile Arg Ser Leu Arg Asp Leu Thr Pro Glu His Leu Pro Leu
225                 230                 235                 240 
Leu Arg Asn Ile Leu His Gln Gly Gln Glu Ala Ile Leu Gln Arg Tyr
                245                 250                 255     
Arg Met Lys Gly Asp His Leu Arg Val Tyr Leu His Tyr Leu Pro Ser
            260                 265                 270         
Tyr Tyr His Leu His Val His Phe Thr Ala Leu Gly Phe Glu Ala Pro
        275                 280                 285             
Gly Ser Gly Val Glu Arg Ala His Leu Leu Ala Glu Val Ile Glu Asn
    290                 295                 300                 
Leu Glu Cys Asp Pro Arg His Tyr Gln Gln Arg Thr Leu Thr Phe Ala
305                 310                 315                 320 
Leu Arg Ala Asp Asp Pro Leu Leu Lys Leu Leu Gln Glu Ala Gln Gln
                325                 330                 335     
Ser
    


<210> 8609
<211> 337
<212> PRT
<213> Homo sapiens

<400> 8609
Met Ala Asp Ala Ala Pro Gln Leu Gly Lys Arg Lys Arg Glu Leu Asp
 1               5                  10                  15      
Val Glu Glu Ala His Ala Ala Ser Thr Glu Glu Lys Glu Ala Gly Val
            20                  25                  30          
Gly Asn Gly Thr Cys Ala Pro Val Arg Leu Pro Phe Ser Gly Phe Arg
        35                  40                  45              
Leu Gln Lys Val Leu Arg Glu Ser Ala Arg Asp Lys Ile Ile Phe Leu
    50                  55                  60                  
His Gly Lys Val Asn Glu Ala Ser Glu Asp Gly Asp Gly Glu Asp Ala
65                  70                  75                  80  
Val Val Ile Leu Glu Lys Thr Pro Phe Gln Val Glu Gln Val Ala Gln
                85                  90                  95      
Leu Leu Thr Gly Ser Pro Glu Leu Gln Leu Gln Phe Ser Asn Asp Ile
            100                 105                 110         
Tyr Ser Thr Tyr His Leu Phe Pro Pro Arg Gln Leu Asn Asp Val Lys
        115                 120                 125             
Thr Thr Val Val Tyr Pro Ala Thr Glu Lys His Leu Gln Lys Tyr Leu
    130                 135                 140                 
Arg Gln Asp Leu Arg Leu Ile Arg Glu Thr Gly Asp Asp Tyr Arg Asn
145                 150                 155                 160 
Ile Thr Leu Pro His Leu Glu Ser Gln Ser Leu Ser Ile Gln Trp Val
                165                 170                 175     
Tyr Asn Ile Leu Asp Lys Lys Ala Glu Ala Asp Arg Ile Val Phe Glu
            180                 185                 190         
Asn Pro Asp Pro Ser Asp Gly Phe Val Leu Ile Pro Asp Leu Lys Trp
        195                 200                 205             
Asn Gln Gln Gln Leu Asp Asp Leu Tyr Leu Ile Ala Ile Cys His Arg
    210                 215                 220                 
Arg Gly Ile Arg Ser Leu Arg Asp Leu Thr Pro Glu His Leu Pro Leu
225                 230                 235                 240 
Leu Arg Asn Ile Leu His Gln Gly Gln Glu Ala Ile Leu Gln Arg Tyr
                245                 250                 255     
Arg Met Lys Gly Asp His Leu Arg Val Tyr Leu His Tyr Leu Pro Ser
            260                 265                 270         
Tyr Tyr His Leu His Val His Phe Thr Ala Leu Gly Phe Glu Ala Pro
        275                 280                 285             
Gly Ser Gly Val Glu Arg Ala His Leu Leu Ala Glu Val Ile Glu Asn
    290                 295                 300                 
Leu Glu Cys Asp Pro Arg His Tyr Gln Gln Arg Thr Leu Thr Phe Ala
305                 310                 315                 320 
Leu Arg Ala Asp Asp Pro Leu Leu Lys Leu Leu Gln Glu Ala Gln Gln
                325                 330                 335     
Ser
    


<210> 8610
<211> 1778
<212> PRT
<213> Homo sapiens

<400> 8610
Gln Ala Gln Asn Cys Leu Thr Lys Leu Tyr Lys Leu Asp Lys Met Gln
 1               5                  10                  15      
Phe Arg Gln Thr Met Arg Asp Tyr Val Asn Lys Asp Ser Leu Asn Asn
            20                  25                  30          
Val Val Asp Phe Leu His Ala Leu Leu Gly Phe Cys Met Glu Pro Val
        35                  40                  45              
Thr Asp Asn Lys Ala Gly Phe Gly Asn Asn Phe Thr Thr Val Asp Asn
    50                  55                  60                  
Lys Ser Thr Ala Gln Asn Val Glu Gly Ile Ile Val Ser Ala Met Phe
65                  70                  75                  80  
Lys Ser Leu Ile Thr Arg Cys Ala Ser Thr Thr His Glu Leu His Ser
                85                  90                  95      
Pro Glu Asn Leu Gly Leu Tyr Cys Asp Ile Arg Gln Leu Val Gln Phe
            100                 105                 110         
Ile Lys Glu Ala His Gly Asn Val Phe Arg Arg Val Ala Leu Ser Ala
        115                 120                 125             
Leu Leu Asp Ser Ala Glu Lys Leu Ala Pro Gly Lys Lys Val Glu Glu
    130                 135                 140                 
Asn Glu Gln Glu Ser Lys Pro Ala Gly Ser Lys Arg Ser Glu Ala Gly
145                 150                 155                 160 
Ser Ile Val Asp Lys Gly Gln Val Ser Ser Ala Pro Glu Glu Cys Arg
                165                 170                 175     
Ser Phe Met Ser Gly Arg Pro Ser Gln Thr Pro Glu His Asp Glu Gln
            180                 185                 190         
Met Gln Gly Ala Asn Leu Gly Arg Lys Asp Phe Trp Arg Lys Met Phe
        195                 200                 205             
Lys Ser Gln Ser Ala Ala Ser Asp Thr Ser Ser Gln Ser Glu Gln Asp
    210                 215                 220                 
Thr Ser Glu Cys Thr Thr Ala His Ser Gly Thr Thr Ser Asp Arg Arg
225                 230                 235                 240 
Ala Arg Ser Arg Ser Arg Arg Ile Ser Leu Arg Lys Lys Leu Lys Leu
                245                 250                 255     
Pro Ile Gly Lys Arg Asn Trp Leu Lys Arg Ser Ser Leu Ser Gly Leu
            260                 265                 270         
Ala Asp Gly Val Glu Asp Leu Leu Asp Ile Ser Ser Val Asp Arg Leu
        275                 280                 285             
Ser Phe Ile Arg Gln Ser Ser Lys Val Lys Phe Thr Ser Ala Val Lys
    290                 295                 300                 
Leu Ser Glu Gly Gly Pro Gly Ser Gly Met Glu Asn Gly Arg Asp Glu
305                 310                 315                 320 
Glu Glu Asn Phe Phe Lys Arg Leu Gly Cys His Ser Phe Asp Asp His
                325                 330                 335     
Leu Ser Pro Asn Gln Asp Gly Gly Lys Ser Lys Asn Val Val Asn Leu
            340                 345                 350         
Gly Ala Ile Arg Gln Gly Met Lys Arg Phe Gln Phe Leu Leu Asn Cys
        355                 360                 365             
Cys Glu Pro Gly Thr Ile Pro Asp Ala Ser Ile Leu Ala Ala Ala Leu
    370                 375                 380                 
Asp Leu Glu Ala Pro Val Val Ala Arg Ala Ala Leu Phe Leu Glu Cys
385                 390                 395                 400 
Ala Arg Phe Val His Arg Cys Asn Arg Gly Asn Trp Pro Glu Trp Met
                405                 410                 415     
Lys Gly His His Val Asn Ile Thr Lys Lys Gly Leu Ser Arg Gly Arg
            420                 425                 430         
Ser Pro Ile Val Gly Asn Lys Arg Asn Gln Lys Leu Gln Trp Asn Ala
        435                 440                 445             
Ala Lys Leu Phe Tyr Gln Trp Gly Asp Ala Ile Gly Val Arg Leu Asn
    450                 455                 460                 
Glu Leu Cys His Gly Glu Ser Glu Ser Pro Ala Asn Leu Leu Gly Leu
465                 470                 475                 480 
Ile Tyr Asp Glu Glu Thr Lys Arg Arg Leu Arg Lys Glu Asp Glu Glu
                485                 490                 495     
Glu Asp Phe Leu Asp Asp Ser Thr Val Asn Pro Ser Lys Cys Gly Cys
            500                 505                 510         
Pro Phe Ala Leu Lys Met Ala Ala Cys Gln Leu Leu Leu Glu Ile Thr
        515                 520                 525             
Thr Phe Leu Arg Glu Thr Phe Ser Cys Leu Pro Arg Pro Arg Thr Glu
    530                 535                 540                 
Pro Leu Val Asp Leu Glu Ser Cys Arg Leu Arg Leu Asp Pro Glu Leu
545                 550                 555                 560 
Asp Arg His Arg Tyr Glu Arg Lys Ile Ser Phe Ala Gly Val Leu Asp
                565                 570                 575     
Glu Asn Glu Asp Ser Lys Asp Ser Leu His Ser Ser Ser His Thr Leu
            580                 585                 590         
Lys Ser Asp Ala Gly Val Glu Glu Lys Lys Glu Gly Ser Pro Trp Ser
        595                 600                 605             
Ala Ser Glu Pro Ser Ile Glu Pro Glu Gly Met Ser Asn Ala Gly Ala
    610                 615                 620                 
Glu Glu Asn Tyr His Arg Asn Met Ser Trp Leu His Val Met Ile Leu
625                 630                 635                 640 
Leu Cys Asn Gln Gln Ser Phe Ile Cys Thr His Val Asp Tyr Cys His
                645                 650                 655     
Pro His Cys Tyr Leu His His Ser Arg Ser Cys Ala Arg Leu Val Arg
            660                 665                 670         
Ala Ile Lys Leu Leu Tyr Gly Asp Ser Val Asp Ser Leu Arg Glu Ser
        675                 680                 685             
Ser Asn Ile Ser Ser Val Ala Leu Arg Gly Lys Lys Gln Lys Glu Cys
    690                 695                 700                 
Ser Asp Lys Ser Cys Leu Arg Thr Pro Ser Leu Lys Lys Arg Val Ser
705                 710                 715                 720 
Asp Ala Asn Leu Glu Gly Lys Lys Asp Ser Gly Met Leu Lys Tyr Ile
                725                 730                 735     
Arg Leu Gln Val Met Ser Leu Ser Pro Ala Pro Leu Ser Leu Leu Ile
            740                 745                 750         
Lys Ala Ala Pro Ile Leu Thr Glu Glu Met Tyr Gly Asp Ile Gln Pro
        755                 760                 765             
Ala Ala Trp Glu Leu Leu Leu Ser Met Asp Glu His Met Ala Gly Ala
    770                 775                 780                 
Ala Ala Ala Met Phe Leu Leu Cys Ala Val Lys Val Pro Glu Ala Val
785                 790                 795                 800 
Ser Asp Met Leu Met Ser Glu Phe His His Pro Glu Thr Val Gln Arg
                805                 810                 815     
Leu Asn Ala Val Leu Lys Phe His Thr Leu Trp Arg Phe Arg Tyr Gln
            820                 825                 830         
Val Trp Pro Arg Met Glu Glu Gly Ala Gln Gln Ile Phe Lys Ile Pro
        835                 840                 845             
Pro Pro Ser Ile Asn Phe Thr Leu Pro Ser Pro Val Leu Gly Met Pro
    850                 855                 860                 
Ser Val Pro Met Phe Asp Pro Pro Trp Val Pro Gln Cys Ser Gly Ser
865                 870                 875                 880 
Val Gln Asp Pro Ile Asn Glu Asp Gln Ser Lys Ser Phe Ser Ala Arg
                885                 890                 895     
Ala Val Ser Arg Ser His Gln Arg Ala Glu His Ile Leu Lys Asn Leu
            900                 905                 910         
Gln Gln Glu Glu Glu Lys Lys Arg Leu Gly Arg Glu Ala Ser Leu Ile
        915                 920                 925             
Thr Ala Ile Pro Ile Thr Gln Glu Ala Cys Tyr Glu Pro Thr Cys Thr
    930                 935                 940                 
Pro Asn Ser Glu Pro Glu Glu Glu Val Glu Glu Val Thr Asn Leu Ala
945                 950                 955                 960 
Ser Arg Arg Leu Ser Val Ser Pro Ser Cys Thr Ser Ser Thr Ser His
                965                 970                 975     
Arg Asn Tyr Ser Phe Arg Arg Gly Ser Val Trp Ser Val Arg Ser Ala
            980                 985                 990         
Val Ser Ala Glu Asp Glu Glu His Thr Thr Glu His Thr Pro Asn His
        995                 1000                1005            
His Val Pro Gln Pro Pro Gln Ala Val Phe Pro Ala Cys Ile Cys Ala
    1010                1015                1020                
Ala Val Leu Pro Ile Val His Leu Met Glu Asp Gly Glu Val Arg Glu
1025                1030                1035                1040
Asp Gly Val Ala Val Ser Ala Val Ala Gln Gln Val Leu Trp Asn Cys
                1045                1050                1055    
Leu Ile Glu Asp Pro Ser Thr Val Leu Arg His Phe Leu Glu Lys Leu
            1060                1065                1070        
Thr Ile Ser Asn Arg Gln Asp Glu Leu Met Tyr Met Leu Arg Lys Leu
        1075                1080                1085            
Leu Leu Asn Ile Gly Asp Phe Pro Ala Gln Thr Ser His Ile Leu Phe
    1090                1095                1100                
Asn Tyr Leu Val Gly Leu Ile Met Tyr Phe Val Arg Thr Pro Cys Glu
1105                1110                1115                1120
Trp Gly Met Asp Ala Ile Ser Ala Thr Leu Thr Phe Leu Trp Glu Val
                1125                1130                1135    
Val Gly Tyr Val Glu Gly Leu Phe Phe Lys Asp Leu Lys Gln Thr Met
            1140                1145                1150        
Lys Lys Glu Gln Cys Glu Val Lys Leu Leu Val Thr Ala Ser Met Pro
        1155                1160                1165            
Gly Thr Lys Thr Leu Val Val His Gly Gln Asn Glu Cys Asp Ile Pro
    1170                1175                1180                
Thr Gln Leu Pro Val His Glu Asp Thr Gln Phe Glu Ala Leu Leu Lys
1185                1190                1195                1200
Glu Cys Leu Glu Phe Phe Asn Ile Pro Glu Ser Gln Ser Thr His Tyr
                1205                1210                1215    
Phe Leu Met Asp Lys Arg Trp Asn Leu Ile His Tyr Asn Lys Thr Tyr
            1220                1225                1230        
Val Arg Asp Ile Tyr Pro Phe Arg Arg Ser Val Ser Pro Gln Leu Asn
        1235                1240                1245            
Leu Val His Met His Pro Glu Lys Gly Gln Glu Leu Ile Gln Lys Gln
    1250                1255                1260                
Val Phe Thr Arg Lys Leu Glu Glu Val Gly Arg Val Leu Phe Leu Ile
1265                1270                1275                1280
Ser Leu Thr Gln Lys Ile Pro Thr Ala His Lys Gln Ser His Val Ser
                1285                1290                1295    
Met Leu Gln Glu Asp Leu Leu Arg Leu Pro Ser Phe Pro Arg Ser Ala
            1300                1305                1310        
Ile Asp Ala Glu Phe Ser Leu Phe Ser Asp Pro Gln Ala Gly Lys Glu
        1315                1320                1325            
Leu Phe Gly Leu Asp Thr Leu Gln Lys Ser Leu Trp Ile Gln Leu Leu
    1330                1335                1340                
Glu Glu Met Phe Leu Gly Met Pro Ser Glu Phe Pro Trp Gly Asp Glu
1345                1350                1355                1360
Ile Met Leu Phe Leu Asn Val Phe Asn Gly Ala Leu Ile Leu His Pro
                1365                1370                1375    
Glu Asp Ser Ala Leu Leu Arg Gln Tyr Ala Ala Thr Val Ile Asn Thr
            1380                1385                1390        
Ala Val His Phe Asn His Leu Phe Ser Leu Ser Gly Tyr Gln Trp Ile
        1395                1400                1405            
Leu Pro Thr Met Leu Gln Val Tyr Ser Asp Tyr Glu Ser Asn Pro Gln
    1410                1415                1420                
Leu Arg Gln Ala Ile Glu Phe Ala Cys His Gln Phe Tyr Ile Leu His
1425                1430                1435                1440
Arg Lys Pro Phe Val Leu Gln Leu Phe Ala Ser Val Ala Pro Leu Leu
                1445                1450                1455    
Glu Phe Pro Asp Ala Ala Asn Asn Gly Pro Ser Lys Gly Val Ser Ala
            1460                1465                1470        
Gln Cys Leu Phe Asp Leu Leu Gln Ser Leu Glu Gly Glu Thr Thr Asp
        1475                1480                1485            
Ile Leu Asp Ile Leu Glu Leu Val Lys Ala Glu Lys Pro Leu Lys Ser
    1490                1495                1500                
Leu Asp Phe Cys Tyr Gly Asn Glu Asp Leu Thr Phe Ser Ile Ser Glu
1505                1510                1515                1520
Ala Ile Lys Leu Cys Val Thr Val Val Ala Tyr Ala Pro Glu Ser Phe
                1525                1530                1535    
Arg Ser Leu Gln Met Leu Met Val Leu Glu Ala Leu Val Pro Cys Tyr
            1540                1545                1550        
Leu Gln Lys Leu Lys Arg Gln Thr Ser Gln Val Glu Thr Val Pro Ala
        1555                1560                1565            
Ala Arg Glu Glu Ile Ala Ala Thr Ala Ala Leu Ala Thr Ser Leu Gln
    1570                1575                1580                
Ala Leu Leu Tyr Ser Val Glu Val Leu Thr Arg Pro Met Thr Ala Pro
1585                1590                1595                1600
Gln Met Ser Arg Cys Asp Gln Gly His Lys Gly Thr Thr Thr Ala Asn
                1605                1610                1615    
His Thr Met Ser Ser Gly Val Asn Thr Arg Tyr Gln Glu Gln Gly Ala
            1620                1625                1630        
Lys Leu His Phe Ile Arg Glu Asn Leu His Leu Leu Glu Glu Gly Gln
        1635                1640                1645            
Gly Ile Pro Arg Glu Glu Leu Asp Glu Arg Ile Ala Arg Glu Glu Phe
    1650                1655                1660                
Arg Arg Pro Arg Glu Ser Leu Leu Asn Ile Cys Thr Glu Phe Tyr Lys
1665                1670                1675                1680
His Cys Gly Pro Arg Leu Lys Ile Leu Gln Asn Leu Ala Gly Glu Pro
                1685                1690                1695    
Arg Val Ile Ala Leu Glu Leu Leu Asp Val Lys Ser His Met Arg Leu
            1700                1705                1710        
Ala Glu Ile Ala His Ser Leu Leu Lys Leu Ala Pro Tyr Asp Thr Gln
        1715                1720                1725            
Thr Met Glu Ser Arg Gly Leu Arg Arg Tyr Ile Met Glu Met Leu Pro
    1730                1735                1740                
Ile Thr Asp Trp Thr Ala Glu Ala Val Arg Pro Ala Leu Ile Leu Ile
1745                1750                1755                1760
Leu Lys Arg Leu Asp Arg Met Phe Asn Lys Ile His Lys Met Pro Thr
                1765                1770                1775    
Leu Arg
        


<210> 8611
<211> 641
<212> PRT
<213> Homo sapiens

<400> 8611
Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser
 1               5                  10                  15      
Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp
            20                  25                  30          
Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu
        35                  40                  45              
Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln
    50                  55                  60                  
Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp
65                  70                  75                  80  
Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn
                85                  90                  95      
Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys
            100                 105                 110         
Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys
        115                 120                 125             
Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile
    130                 135                 140                 
Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp
145                 150                 155                 160 
Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro
                165                 170                 175     
Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu
            180                 185                 190         
Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser
        195                 200                 205             
Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly
    210                 215                 220                 
Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His
225                 230                 235                 240 
Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn
                245                 250                 255     
Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg
            260                 265                 270         
Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe
        275                 280                 285             
Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu
    290                 295                 300                 
Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala
305                 310                 315                 320 
Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu
                325                 330                 335     
Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp
            340                 345                 350         
Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala
        355                 360                 365             
Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys
    370                 375                 380                 
Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser
385                 390                 395                 400 
Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg
                405                 410                 415     
Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser
            420                 425                 430         
Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala
        435                 440                 445             
Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile
    450                 455                 460                 
Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile
465                 470                 475                 480 
Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly
                485                 490                 495     
Lys Ala Ser Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys
            500                 505                 510         
Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu
        515                 520                 525             
Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser
    530                 535                 540                 
Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly
545                 550                 555                 560 
Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu
                565                 570                 575     
Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe
            580                 585                 590         
Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser
        595                 600                 605             
Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala
    610                 615                 620                 
Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val
625                 630                 635                 640 
Asp
    


<210> 8612
<211> 641
<212> PRT
<213> Homo sapiens

<400> 8612
Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser
 1               5                  10                  15      
Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp
            20                  25                  30          
Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu
        35                  40                  45              
Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln
    50                  55                  60                  
Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp
65                  70                  75                  80  
Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn
                85                  90                  95      
Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys
            100                 105                 110         
Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys
        115                 120                 125             
Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile
    130                 135                 140                 
Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp
145                 150                 155                 160 
Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro
                165                 170                 175     
Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu
            180                 185                 190         
Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser
        195                 200                 205             
Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly
    210                 215                 220                 
Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His
225                 230                 235                 240 
Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn
                245                 250                 255     
Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg
            260                 265                 270         
Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe
        275                 280                 285             
Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu
    290                 295                 300                 
Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala
305                 310                 315                 320 
Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu
                325                 330                 335     
Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp
            340                 345                 350         
Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala
        355                 360                 365             
Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys
    370                 375                 380                 
Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser
385                 390                 395                 400 
Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg
                405                 410                 415     
Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser
            420                 425                 430         
Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala
        435                 440                 445             
Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile
    450                 455                 460                 
Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile
465                 470                 475                 480 
Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly
                485                 490                 495     
Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys
            500                 505                 510         
Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu
        515                 520                 525             
Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser
    530                 535                 540                 
Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly
545                 550                 555                 560 
Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu
                565                 570                 575     
Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe
            580                 585                 590         
Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser
        595                 600                 605             
Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala
    610                 615                 620                 
Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val
625                 630                 635                 640 
Asp
    


<210> 8613
<211> 1053
<212> PRT
<213> Homo sapiens

<400> 8613
Met Ala Glu Phe Thr Ser Tyr Lys Glu Thr Ala Ser Ser Arg His Leu
 1               5                  10                  15      
Arg Phe Lys Leu Gln Ser Leu Ser Arg Arg Leu Asp Glu Leu Glu Glu
            20                  25                  30          
Ala Thr Lys Asn Leu Gln Lys Ala Glu Asp Glu Leu Leu Asp Leu Gln
        35                  40                  45              
Asp Lys Val Ile Gln Ala Glu Gly Ser Asn Ser Ser Met Leu Ala Glu
    50                  55                  60                  
Ile Glu Val Leu Arg Gln Arg Val Leu Arg Ile Glu Gly Lys Asp Glu
65                  70                  75                  80  
Glu Ile Lys Arg Ala Glu Asp Leu Cys Arg Leu Met Lys Glu Lys Leu
                85                  90                  95      
Glu Glu Glu Glu Asn Leu Thr Arg Glu Leu Lys Ser Glu Ile Glu Arg
            100                 105                 110         
Leu Gln Lys Arg Met Ala Glu Leu Glu Lys Leu Glu Glu Ala Phe Ser
        115                 120                 125             
Arg Ser Lys Asn Asp Cys Thr Gln Leu Cys Leu Ser Leu Asn Glu Glu
    130                 135                 140                 
Arg Asn Leu Thr Lys Lys Ile Ser Ser Glu Leu Glu Met Leu Arg Val
145                 150                 155                 160 
Lys Val Lys Glu Leu Glu Ser Ser Glu Asp Arg Leu Asp Lys Thr Glu
                165                 170                 175     
Gln Ser Leu Ala Ser Glu Leu Glu Lys Leu Lys Ser Leu Thr Leu Ser
            180                 185                 190         
Phe Val Ser Glu Arg Lys Tyr Leu Asn Glu Lys Glu Lys Glu Asn Glu
        195                 200                 205             
Lys Leu Ile Lys Glu Leu Thr Gln Lys Leu Glu Gln Asn Lys Lys Met
    210                 215                 220                 
Asn Arg Asp Tyr Thr Arg Asn Ala Ser Asn Leu Glu Arg Asn Asp Leu
225                 230                 235                 240 
Arg Ile Glu Asp Gly Ile Ser Ser Thr Leu Pro Ser Lys Glu Ser Arg
                245                 250                 255     
Arg Lys Gly Gly Leu Asp Tyr Leu Lys Gln Val Glu Asn Glu Thr Arg
            260                 265                 270         
Asn Lys Ser Glu Asn Glu Lys Asn Arg Asn Gln Glu Asp Asn Lys Val
        275                 280                 285             
Lys Asp Leu Asn Gln Glu Ile Glu Lys Leu Lys Thr Gln Ile Lys His
    290                 295                 300                 
Phe Glu Ser Leu Glu Glu Glu Leu Lys Lys Met Lys Ser Lys Asn Asn
305                 310                 315                 320 
Asp Leu Gln Asp Asn Tyr Leu Ser Glu Gln Asn Lys Asn Lys Leu Leu
                325                 330                 335     
Ala Ser Gln Leu Glu Glu Ile Lys Leu Gln Ile Lys Lys Gln Lys Glu
            340                 345                 350         
Leu Glu Asn Gly Glu Val Glu Gly Glu Asp Ala Phe Leu Ser Ser Lys
        355                 360                 365             
Gly Arg His Glu Arg Thr Lys Phe Arg Gly His Gly Ser Glu Ala Ser
    370                 375                 380                 
Val Ser Lys His Thr Ala Arg Glu Leu Ser Pro Gln His Lys Arg Glu
385                 390                 395                 400 
Arg Leu Arg Asn Arg Glu Phe Ala Leu Asn Asn Glu Asn Tyr Ser Leu
                405                 410                 415     
Ser Asn Arg Gln Val Ser Ser Pro Ser Phe Thr Asn Arg Arg Ala Ala
            420                 425                 430         
Lys Ala Ser His Met Gly Val Ser Thr Asp Ser Gly Thr Gln Glu Thr
        435                 440                 445             
Lys Lys Thr Glu Asp Arg Phe Val Pro Ser Ser Ser Lys Ser Glu Gly
    450                 455                 460                 
Lys Lys Ser Arg Glu Gln Pro Ser Val Leu Ser Arg Tyr Pro Pro Ala
465                 470                 475                 480 
Ala Gln Glu His Ser Lys Ala Trp Lys Gly Thr Ser Lys Pro Gly Thr
                485                 490                 495     
Glu Ser Gly Leu Lys Gly Lys Val Glu Lys Thr Thr Arg Thr Phe Ser
            500                 505                 510         
Asp Thr Thr His Gly Ser Val Pro Ser Asp Pro Leu Gly Arg Ala Asp
        515                 520                 525             
Lys Ala Ser Asp Thr Ser Ser Glu Thr Val Phe Gly Lys Arg Gly His
    530                 535                 540                 
Val Leu Gly Asn Gly Ser Gln Val Thr Gln Ala Ala Asn Ser Gly Cys
545                 550                 555                 560 
Ser Lys Ala Ile Gly Ala Leu Ala Ser Ser Arg Arg Ser Ser Ser Glu
                565                 570                 575     
Gly Leu Ser Lys Gly Lys Lys Ala Ala Asn Gly Leu Glu Ala Asp Asn
            580                 585                 590         
Ser Cys Pro Asn Ser Lys Ala Pro Val Leu Ser Lys Tyr Pro Tyr Ser
        595                 600                 605             
Cys Arg Ser Gln Glu Asn Ile Leu Gln Gly Phe Ser Thr Ser His Lys
    610                 615                 620                 
Glu Gly Val Asn Gln Pro Ala Ala Val Val Met Glu Asp Ser Ser Pro
625                 630                 635                 640 
His Glu Ala Leu Arg Cys Arg Val Ile Lys Ser Ser Gly Arg Glu Lys
                645                 650                 655     
Pro Asp Ser Asp Asp Asp Leu Asp Ile Ala Ser Leu Val Thr Ala Lys
            660                 665                 670         
Leu Val Asn Thr Thr Ile Thr Pro Glu Pro Glu Pro Lys Pro Gln Pro
        675                 680                 685             
Asn Ser Arg Glu Lys Ala Lys Thr Arg Gly Ala Pro Arg Thr Ser Leu
    690                 695                 700                 
Phe Glu Asn Asp Lys Asp Ala Gly Met Glu Asn Glu Ser Val Lys Ser
705                 710                 715                 720 
Val Arg Ala Ser Thr Asn Thr Met Glu Leu Pro Asp Thr Asn Gly Ala
                725                 730                 735     
Gly Val Lys Ser Gln Arg Pro Phe Ser Pro Arg Glu Ala Leu Arg Ser
            740                 745                 750         
Arg Ala Ile Ile Lys Pro Val Ile Val Asp Lys Asp Val Lys Lys Ile
        755                 760                 765             
Met Gly Gly Ser Gly Thr Glu Thr Thr Leu Glu Lys Gln Lys Pro Val
    770                 775                 780                 
Ser Lys Pro Gly Pro Asn Lys Val Thr Ser Ser Ile Thr Ile Tyr Pro
785                 790                 795                 800 
Ser Asp Ser Ser Ser Pro Arg Ala Ala Pro Gly Glu Ala Leu Arg Glu
                805                 810                 815     
Arg His Thr Ser Thr Ser Asn Ile Gln Val Gly Leu Ala Glu Leu Thr
            820                 825                 830         
Ser Val Ser Asn His Val Ser Ser Pro Phe Glu Leu Ser Ile His Lys
        835                 840                 845             
His Asp Ile Thr Leu Gln Leu Ala Glu Ala Glu Arg Met Ala Asp Gly
    850                 855                 860                 
Pro Leu Lys Asn Arg Pro Glu Thr Val Val Ser Arg Ser Ser Ile Ile
865                 870                 875                 880 
Ile Lys Pro Ser Asp Pro Val Glu Arg Asn Ser His Ala Pro Pro Ala
                885                 890                 895     
Glu Thr Ile Arg Trp Lys Ser His Ser Ala Pro Ser Glu Val Gly Phe
            900                 905                 910         
Ser Asp Ala Arg His Val Thr Val Arg Asn Ala Trp Lys Ser Arg Arg
        915                 920                 925             
Asp Leu Lys Ser Leu Glu Asp Pro Pro Thr Arg Ile Gly Lys Asn Val
    930                 935                 940                 
Glu Ser Thr Asn Ser Asn Ala Tyr Thr Gln Arg Ser Ser Thr Asp Phe
945                 950                 955                 960 
Ser Glu Leu Glu Gln Pro Arg Ser Cys Leu Phe Glu Gln Gly Thr Arg
                965                 970                 975     
Arg Val Gly Pro Ser Ser Gly Asp Ala Pro Glu Pro Ser Ser Arg Arg
            980                 985                 990         
Thr Gln Ser Ser Leu Thr Val Ser Glu Val Leu Thr Arg Arg Asn Arg
        995                 1000                1005            
Val Gly Asp Thr Ile Thr Val Ala Ala Trp Asn His Ser Ala Ser Met
    1010                1015                1020                
Val Ser Ser Ser Leu Ser Pro Leu Ser Leu Phe Ser Leu Pro Phe Pro
1025                1030                1035                1040
Ser Leu Pro Phe Pro Phe Ser Pro Leu Leu Trp Pro Val
                1045                1050            


<210> 8614
<211> 354
<212> PRT
<213> Homo sapiens

<400> 8614
Met Met Ser Tyr Leu Lys Gln Pro Pro Tyr Gly Met Asn Gly Leu Gly
 1               5                  10                  15      
Leu Ala Gly Pro Ala Met Asp Leu Leu His Pro Ser Val Gly Tyr Pro
            20                  25                  30          
Ala Thr Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg Ser
        35                  40                  45              
Gln Leu Asp Val Leu Glu Ala Leu Phe Ala Lys Thr Arg Tyr Pro Asp
    50                  55                  60                  
Ile Phe Met Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu Ser
65                  70                  75                  80  
Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln Gln
                85                  90                  95      
Gln Gln Ser Gly Ser Gly Thr Lys Ser Arg Pro Ala Lys Lys Lys Ser
            100                 105                 110         
Ser Pro Val Arg Glu Ser Ser Gly Ser Glu Ser Ser Gly Gln Phe Thr
        115                 120                 125             
Pro Pro Ala Val Ser Ser Ser Ala Ser Ser Ser Ser Ser Ala Ser Ser
    130                 135                 140                 
Ser Ser Ala Asn Pro Ala Ala Ala Ala Ala Ala Gly Leu Gly Gly Asn
145                 150                 155                 160 
Pro Val Ala Ala Ala Ser Ser Leu Ser Thr Pro Ala Ala Ser Ser Ile
                165                 170                 175     
Trp Ser Pro Ala Ser Ile Ser Pro Gly Ser Ala Pro Ala Ser Val Ser
            180                 185                 190         
Val Pro Glu Pro Leu Ala Ala Pro Ser Asn Thr Ser Cys Met Gln Arg
        195                 200                 205             
Ser Val Ala Ala Gly Ala Ala Thr Ala Ala Ala Ser Tyr Pro Met Ser
    210                 215                 220                 
Tyr Gly Gln Gly Gly Ser Tyr Gly Gln Gly Tyr Pro Thr Pro Ser Ser
225                 230                 235                 240 
Ser Tyr Phe Gly Gly Val Asp Cys Ser Ser Tyr Leu Ala Pro Met His
                245                 250                 255     
Ser His His His Pro His Gln Leu Ser Pro Met Ala Pro Ser Ser Met
            260                 265                 270         
Ala Gly His His His His His Pro His Ala His His Pro Leu Ser Gln
        275                 280                 285             
Ser Ser Gly His His His His His His His His His His Gln Gly Tyr
    290                 295                 300                 
Gly Gly Ser Gly Leu Ala Phe Asn Ser Ala Asp Cys Leu Asp Tyr Lys
305                 310                 315                 320 
Glu Pro Gly Ala Ala Ala Ala Ser Ser Ala Trp Lys Leu Asn Phe Asn
                325                 330                 335     
Ser Pro Asp Cys Leu Asp Tyr Lys Asp Gln Ala Ser Trp Arg Phe Gln
            340                 345                 350         
Val Leu
        


<210> 8615
<211> 686
<212> PRT
<213> Homo sapiens

<400> 8615
Arg Pro Arg Arg Glu Leu Ser Arg Gln Arg Arg Gly Ala Arg Gly Leu
 1               5                  10                  15      
Glu Gly Ala Glu Met Glu Gln Glu Pro Gln Asn Gly Glu Pro Ala Glu
            20                  25                  30          
Ile Lys Ile Ile Arg Glu Ala Tyr Lys Lys Ala Phe Leu Phe Val Asn
        35                  40                  45              
Lys Gly Leu Asn Thr Asp Glu Leu Gly Gln Lys Glu Glu Ala Lys Asn
    50                  55                  60                  
Tyr Tyr Lys Gln Gly Ile Gly His Leu Leu Arg Gly Ile Ser Ile Ser
65                  70                  75                  80  
Ser Lys Glu Ser Glu His Thr Gly Pro Gly Trp Glu Ser Ala Arg Gln
                85                  90                  95      
Met Gln Gln Lys Met Lys Glu Thr Leu Gln Asn Val Arg Thr Arg Leu
            100                 105                 110         
Glu Ile Leu Glu Lys Gly Leu Ala Thr Ser Leu Gln Asn Asp Leu Gln
        115                 120                 125             
Glu Val Pro Lys Leu Tyr Pro Glu Phe Pro Pro Lys Asp Met Cys Glu
    130                 135                 140                 
Lys Leu Pro Glu Pro Gln Ser Phe Ser Ser Ala Pro Gln His Ala Glu
145                 150                 155                 160 
Val Asn Gly Asn Thr Ser Thr Pro Ser Ala Gly Ala Val Ala Ala Pro
                165                 170                 175     
Ala Ser Leu Ser Leu Pro Ser Gln Ser Cys Pro Ala Glu Ala Pro Pro
            180                 185                 190         
Ala Tyr Thr Pro Gln Ala Ala Glu Gly His Tyr Thr Val Ser Tyr Gly
        195                 200                 205             
Thr Asp Ser Gly Glu Phe Ser Ser Val Gly Glu Glu Phe Tyr Arg Asn
    210                 215                 220                 
His Ser Gln Pro Pro Pro Leu Glu Thr Leu Gly Leu Asp Ala Asp Glu
225                 230                 235                 240 
Leu Ile Leu Ile Pro Asn Gly Val Gln Ile Phe Phe Val Asn Pro Ala
                245                 250                 255     
Gly Glu Val Ser Ala Pro Ser Tyr Pro Gly Tyr Leu Arg Ile Val Arg
            260                 265                 270         
Phe Leu Asp Asn Ser Leu Asp Thr Val Leu Asn Arg Pro Pro Gly Phe
        275                 280                 285             
Leu Gln Val Cys Asp Trp Leu Tyr Pro Leu Val Pro Asp Arg Ser Pro
    290                 295                 300                 
Val Leu Lys Cys Thr Ala Gly Ala Tyr Met Phe Pro Asp Thr Met Leu
305                 310                 315                 320 
Gln Ala Ala Gly Cys Phe Val Gly Val Val Leu Ser Ser Glu Leu Pro
                325                 330                 335     
Glu Asp Asp Arg Glu Leu Phe Glu Asp Leu Leu Arg Gln Met Ser Asp
            340                 345                 350         
Leu Arg Leu Gln Ala Asn Trp Asn Arg Ala Glu Glu Glu Asn Glu Phe
        355                 360                 365             
Gln Ile Pro Gly Arg Thr Arg Pro Ser Ser Asp Gln Leu Lys Glu Ala
    370                 375                 380                 
Ser Gly Thr Asp Val Lys Gln Leu Asp Gln Gly Asn Lys Asp Val Arg
385                 390                 395                 400 
His Lys Gly Lys Arg Gly Lys Arg Ala Lys Asp Thr Ser Ser Glu Glu
                405                 410                 415     
Val Asn Leu Ser His Ile Val Pro Cys Glu Pro Val Pro Glu Glu Lys
            420                 425                 430         
Pro Lys Glu Leu Pro Glu Trp Ser Glu Lys Val Ala His Asn Ile Leu
        435                 440                 445             
Ser Gly Ala Ser Trp Val Ser Trp Gly Leu Val Lys Gly Ala Glu Ile
    450                 455                 460                 
Thr Gly Lys Ala Ile Gln Lys Gly Ala Ser Lys Leu Arg Glu Arg Ile
465                 470                 475                 480 
Gln Pro Glu Glu Lys Pro Val Glu Val Ser Pro Ala Val Thr Lys Gly
                485                 490                 495     
Leu Tyr Ile Ala Lys Gln Ala Thr Gly Gly Ala Ala Lys Val Ser Gln
            500                 505                 510         
Phe Leu Val Asp Gly Val Cys Thr Val Ala Asn Cys Val Gly Lys Glu
        515                 520                 525             
Leu Ala Pro His Val Lys Lys His Gly Ser Lys Leu Val Pro Glu Ser
    530                 535                 540                 
Leu Lys Lys Asp Lys Asp Gly Lys Ser Pro Leu Asp Gly Ala Met Val
545                 550                 555                 560 
Val Ala Ala Ser Ser Val Gln Gly Phe Ser Thr Val Trp Gln Gly Leu
                565                 570                 575     
Glu Cys Ala Ala Lys Cys Ile Val Asn Asn Val Ser Ala Glu Thr Val
            580                 585                 590         
Gln Thr Val Arg Tyr Lys Tyr Gly Tyr Asn Ala Gly Glu Ala Thr His
        595                 600                 605             
His Ala Val Asp Ser Ala Val Asn Val Gly Val Thr Ala Tyr Asn Ile
    610                 615                 620                 
Asn Asn Ile Gly Ile Lys Ala Met Val Lys Lys Thr Ala Thr Gln Thr
625                 630                 635                 640 
Gly His Thr Leu Leu Glu Asp Tyr Gln Ile Val Asp Asn Ser Gln Arg
                645                 650                 655     
Glu Asn Gln Glu Gly Ala Ala Asn Val Asn Val Arg Gly Glu Lys Asp
            660                 665                 670         
Glu Gln Thr Lys Glu Val Lys Glu Ala Lys Lys Lys Asp Lys
        675                 680                 685     


<210> 8616
<211> 666
<212> PRT
<213> Homo sapiens

<400> 8616
Met Glu Gln Glu Pro Gln Asn Gly Glu Pro Ala Glu Ile Lys Ile Ile
 1               5                  10                  15      
Arg Glu Ala Tyr Lys Lys Ala Phe Leu Phe Val Asn Lys Gly Leu Asn
            20                  25                  30          
Thr Asp Glu Leu Gly Gln Lys Glu Glu Ala Lys Asn Tyr Tyr Lys Gln
        35                  40                  45              
Gly Ile Gly His Leu Leu Arg Gly Ile Ser Ile Ser Ser Lys Glu Ser
    50                  55                  60                  
Glu His Thr Gly Pro Gly Trp Glu Ser Ala Arg Gln Met Gln Gln Lys
65                  70                  75                  80  
Met Lys Glu Thr Leu Gln Asn Val Arg Thr Arg Leu Glu Ile Leu Glu
                85                  90                  95      
Lys Gly Leu Ala Thr Ser Leu Gln Asn Asp Leu Gln Glu Val Pro Lys
            100                 105                 110         
Leu Tyr Pro Glu Phe Pro Pro Lys Asp Met Cys Glu Lys Leu Pro Glu
        115                 120                 125             
Pro Gln Ser Phe Ser Ser Ala Pro Gln His Ala Glu Val Asn Gly Asn
    130                 135                 140                 
Thr Ser Thr Pro Ser Ala Gly Ala Val Ala Ala Pro Ala Ser Leu Ser
145                 150                 155                 160 
Leu Pro Ser Gln Ser Cys Pro Ala Glu Ala Pro Pro Ala Tyr Thr Pro
                165                 170                 175     
Gln Ala Ala Glu Gly His Tyr Thr Val Ser Tyr Gly Thr Asp Ser Gly
            180                 185                 190         
Glu Phe Ser Ser Val Gly Glu Glu Phe Tyr Arg Asn His Ser Gln Pro
        195                 200                 205             
Pro Pro Leu Glu Thr Leu Gly Leu Asp Ala Asp Glu Leu Ile Leu Ile
    210                 215                 220                 
Pro Asn Gly Val Gln Ile Phe Phe Val Asn Pro Ala Gly Glu Val Ser
225                 230                 235                 240 
Ala Pro Ser Tyr Pro Gly Tyr Leu Arg Ile Val Arg Phe Leu Asp Asn
                245                 250                 255     
Ser Leu Asp Thr Val Leu Asn Arg Pro Pro Gly Phe Leu Gln Val Cys
            260                 265                 270         
Asp Trp Leu Tyr Pro Leu Val Pro Asp Arg Ser Pro Val Leu Lys Cys
        275                 280                 285             
Thr Ala Gly Ala Tyr Met Phe Pro Asp Thr Met Leu Gln Ala Ala Gly
    290                 295                 300                 
Cys Phe Val Gly Val Val Leu Ser Ser Glu Leu Pro Glu Asp Asp Arg
305                 310                 315                 320 
Glu Leu Phe Glu Asp Leu Leu Arg Gln Met Ser Asp Leu Arg Leu Gln
                325                 330                 335     
Ala Asn Trp Asn Arg Ala Glu Glu Glu Asn Glu Phe Gln Ile Pro Gly
            340                 345                 350         
Arg Thr Arg Pro Ser Ser Asp Gln Leu Lys Glu Ala Ser Gly Thr Asp
        355                 360                 365             
Val Lys Gln Leu Asp Gln Gly Asn Lys Asp Val Arg His Lys Gly Lys
    370                 375                 380                 
Arg Gly Lys Arg Ala Lys Asp Thr Ser Ser Glu Glu Val Asn Leu Ser
385                 390                 395                 400 
His Ile Val Pro Cys Glu Pro Val Pro Glu Glu Lys Pro Lys Glu Leu
                405                 410                 415     
Pro Glu Trp Ser Glu Lys Val Ala His Asn Ile Leu Ser Gly Ala Ser
            420                 425                 430         
Trp Val Ser Trp Gly Leu Val Lys Gly Ala Glu Ile Thr Gly Lys Ala
        435                 440                 445             
Ile Gln Lys Gly Ala Ser Lys Leu Arg Glu Arg Ile Gln Pro Glu Glu
    450                 455                 460                 
Lys Pro Val Glu Val Ser Pro Ala Val Thr Lys Gly Leu Tyr Ile Ala
465                 470                 475                 480 
Lys Gln Ala Thr Gly Gly Ala Ala Lys Val Ser Gln Phe Leu Val Asp
                485                 490                 495     
Gly Val Cys Thr Val Ala Asn Cys Val Gly Lys Glu Leu Ala Pro His
            500                 505                 510         
Val Lys Lys His Gly Ser Lys Leu Val Pro Glu Ser Leu Lys Lys Asp
        515                 520                 525             
Lys Asp Gly Lys Ser Pro Leu Asp Gly Ala Met Val Val Ala Ala Ser
    530                 535                 540                 
Ser Val Gln Gly Phe Ser Thr Val Trp Gln Gly Leu Glu Cys Ala Ala
545                 550                 555                 560 
Lys Cys Ile Val Asn Asn Val Ser Ala Glu Thr Val Gln Thr Val Arg
                565                 570                 575     
Tyr Lys Tyr Gly Tyr Asn Ala Gly Glu Ala Thr His His Ala Val Asp
            580                 585                 590         
Ser Ala Val Asn Val Gly Val Thr Ala Tyr Asn Ile Asn Asn Ile Gly
        595                 600                 605             
Ile Lys Ala Met Val Lys Lys Thr Ala Thr Gln Thr Gly His Thr Leu
    610                 615                 620                 
Leu Glu Asp Tyr Gln Ile Val Asp Asn Ser Gln Arg Glu Asn Gln Glu
625                 630                 635                 640 
Gly Ala Ala Asn Val Asn Val Arg Gly Glu Lys Asp Glu Gln Thr Lys
                645                 650                 655     
Glu Val Lys Glu Ala Lys Lys Lys Asp Lys
            660                 665     


<210> 8617
<211> 93
<212> PRT
<213> Homo sapiens

<400> 8617
Met Val Tyr Leu Thr Ser Tyr Leu Leu Pro Ser Leu Met Ser Asn Thr
 1               5                  10                  15      
Ser Leu Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Arg Val Gly Met
            20                  25                  30          
Glu Ala Thr Asp Asp Trp Leu Asn Lys Val Ile Ser Glu Leu Asn Gly
        35                  40                  45              
Lys Asn Ile Glu Asp Ile Ile Ala Gln Gly Ile Gly Glu Leu Ala Ser
    50                  55                  60                  
Val Pro Ala Gly Gly Ala Val Ala Leu Ser Ala Ser Leu Gly Ser Ala
65                  70                  75                  80  
Gly Pro Ala Ala Gly Ser Thr Pro Ala Ala Glu Glu Arg
                85                  90              


<210> 8618
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8618
Met Val Thr Val Thr Leu Lys Asp Ile Asn Leu Ser Trp Leu Asp Val
 1               5                  10                  15      
Asp Glu Gly Phe Pro Arg Asp Gly Gly Leu Asp Gly Arg Gln Val Leu
            20                  25                  30          
Val Ala His Asp Gly Cys Ile Leu Gln Val Pro Ser Thr Thr Arg Leu
        35                  40                  45              
Ser Met Ala Lys Leu Asn Trp Leu Ser Val Asp Ser Asn His Trp Lys
    50                  55                  60                  
Asp Trp Glu Asp Gly Ser Asp Glu Ala Met Ser Asp Phe Asp Tyr Phe
65                  70                  75                  80  
Ser Glu Met Met Asn His Met Gly Gly Glu Glu Asp Val Asp Leu Ala
                85                  90                  95      
Asp Gly Ala Asp Asp His Ser Gln Asp Ser Asp Asp Glu Lys Met Pro
            100                 105                 110         
Asp Leu Glu
        115 


<210> 8619
<211> 82
<212> PRT
<213> Homo sapiens

<400> 8619
Met Val Asp Leu Leu Ser Met Ser Gln Asn Ile Ser Pro Tyr Lys Asn
 1               5                  10                  15      
Pro Met Arg Phe Ile Phe Phe Ser Pro Ile Leu Arg Glu Glu Lys Phe
            20                  25                  30          
Ser Ser Glu Ser Cys Arg Asn Ile Gly Asp Ile Ser Lys Ser Gln Pro
        35                  40                  45              
Ile Gly Gly Ser His Gln Cys Val Leu Glu Gly Thr Asn Ile Glu Leu
    50                  55                  60                  
Leu Asn Ser Tyr Ser Arg Asn Tyr Gly Ala Val Val Lys Ser Trp Leu
65                  70                  75                  80  
Gly Ala
        


<210> 8620
<211> 366
<212> PRT
<213> Homo sapiens

<400> 8620
Met Thr Val Arg Asn Ile Ala Ser Ile Cys Asn Met Gly Thr Asn Ala
 1               5                  10                  15      
Ser Ala Leu Glu Lys Asp Ile Gly Pro Glu Gln Phe Pro Ile Asn Glu
            20                  25                  30          
His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn Ser
        35                  40                  45              
Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Asn Val Leu
    50                  55                  60                  
Ala Tyr Lys Ala Gln Gln Lys Lys Lys Glu Asn Leu Leu Thr Cys Leu
65                  70                  75                  80  
Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly Val
                85                  90                  95      
Ile Pro Pro Lys Lys Phe Ile Ser Arg Leu Arg Lys Glu Asn Asp Leu
            100                 105                 110         
Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr Leu
        115                 120                 125             
Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Lys Lys Gln Glu Lys
    130                 135                 140                 
Gln Asn Gly Lys Leu Lys Asn Gly Asn Met Asn Glu Pro Ala Glu Asn
145                 150                 155                 160 
Asn Lys Pro Glu Leu Thr Trp Val His Glu Ile Phe Gln Gly Thr Leu
                165                 170                 175     
Thr Asn Glu Thr Arg Cys Leu Asn Cys Glu Thr Val Ser Ser Lys Asp
            180                 185                 190         
Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser Ile
        195                 200                 205             
Thr His Cys Leu Arg Asp Phe Ser Asn Thr Glu Thr Leu Cys Ser Glu
    210                 215                 220                 
Gln Lys Tyr Tyr Cys Glu Thr Cys Cys Ser Lys Gln Glu Ala Gln Lys
225                 230                 235                 240 
Arg Met Arg Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu Lys
                245                 250                 255     
Arg Phe Lys Tyr Met Glu Gln Leu His Arg Tyr Thr Lys Leu Ser Tyr
            260                 265                 270         
Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Ser Asp
        275                 280                 285             
Ala Val Asn Leu Asp Arg Met Tyr Asp Leu Val Ala Val Val Val His
    290                 295                 300                 
Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Thr Ile Val Lys Ser
305                 310                 315                 320 
His Gly Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile Asp
                325                 330                 335     
Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser Lys
            340                 345                 350         
Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg Glu
        355                 360                 365     


<210> 8621
<211> 341
<212> PRT
<213> Homo sapiens

<400> 8621
Met Thr Gly Ser Asn Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln
 1               5                  10                  15      
Arg Cys Gln Ala Arg Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn
            20                  25                  30          
Gly Glu Leu Tyr His Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg
        35                  40                  45              
Pro Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys
    50                  55                  60                  
Glu His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly
65                  70                  75                  80  
Glu Phe Ile Ile Gly Arg Val Ile Lys Ala Met Asn Asn Asn Trp His
                85                  90                  95      
Pro Gly Cys Phe Arg Cys Glu Leu Cys Asp Val Glu Leu Ala Asp Leu
            100                 105                 110         
Gly Phe Val Lys Asn Ala Gly Arg His Leu Cys Arg Pro Cys His Asn
        115                 120                 125             
Arg Glu Lys Ala Lys Gly Leu Gly Lys Tyr Ile Cys Gln Arg Cys His
    130                 135                 140                 
Leu Val Ile Asp Glu Gln Pro Leu Met Phe Arg Ser Asp Ala Tyr His
145                 150                 155                 160 
Pro Asp His Phe Asn Cys Thr His Cys Gly Lys Glu Leu Thr Ala Glu
                165                 170                 175     
Ala Arg Glu Leu Lys Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys
            180                 185                 190         
Met Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg
        195                 200                 205             
Val Val Asn Ala Leu Gly Lys Gln Trp His Val Glu His Phe Val Cys
    210                 215                 220                 
Ala Lys Cys Glu Lys Pro Phe Leu Gly His Arg His Tyr Glu Lys Lys
225                 230                 235                 240 
Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val
                245                 250                 255     
Cys Tyr Asn Cys Ser His Val Ile Glu Gly Asp Val Val Ser Ala Leu
            260                 265                 270         
Asn Lys Ala Trp Cys Val Ser Cys Phe Ser Cys Ser Thr Cys Asn Ser
        275                 280                 285             
Lys Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val
    290                 295                 300                 
Cys Lys Arg Cys Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu
305                 310                 315                 320 
Lys Lys Leu Ser Glu Leu Thr Ser Arg Lys Ala Gln Pro Lys Ala Thr
                325                 330                 335     
Asp Leu Asn Ser Ala
            340     


<210> 8622
<211> 206
<212> PRT
<213> Homo sapiens

<400> 8622
Met Thr Gly Ser Asn Met Ser Asp Ala Leu Ala Asn Ala Val Cys Gln
 1               5                  10                  15      
Arg Cys Gln Ala Arg Phe Ser Pro Ala Glu Arg Ile Val Asn Ser Asn
            20                  25                  30          
Gly Glu Leu Tyr His Glu His Cys Phe Val Cys Ala Gln Cys Phe Arg
        35                  40                  45              
Pro Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys
    50                  55                  60                  
Glu His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys Gly Ser Cys Gly
65                  70                  75                  80  
Glu Phe Ile Ile Gly Arg Val Ile Lys Ala Lys Cys Glu Lys Pro Phe
                85                  90                  95      
Leu Gly His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr
            100                 105                 110         
His Tyr Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val
        115                 120                 125             
Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser
    130                 135                 140                 
Cys Phe Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys
145                 150                 155                 160 
Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys
                165                 170                 175     
Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr
            180                 185                 190         
Ser Arg Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala
        195                 200                 205     


<210> 8623
<211> 36
<212> PRT
<213> Homo sapiens

<400> 8623
Met Ser Arg Ile Asn Lys Tyr Leu Phe Ser Asn Ser Asp Ser Asn Phe
 1               5                  10                  15      
Ser His Phe Ser Val Ser Asn Val Ser Thr Tyr Cys Val Pro Gly Asn
            20                  25                  30          
Lys Asp Thr Asn
        35      


<210> 8624
<211> 583
<212> PRT
<213> Homo sapiens

<400> 8624
Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu
 1               5                  10                  15      
Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln
            20                  25                  30          
Val Val Lys Thr Val Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln
        35                  40                  45              
Tyr Val Asp Ser Lys Gly Tyr Ser Thr Trp Leu Lys Leu Asn Lys Lys
    50                  55                  60                  
Val Thr Gln Gln Asp Val Lys Lys Glu Asn Pro Leu Gln Phe Lys Phe
65                  70                  75                  80  
Arg Ala Lys Phe Phe Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Glu
                85                  90                  95      
Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Ala Ile Leu Asn
            100                 105                 110         
Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr
        115                 120                 125             
Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asn Lys Glu Ile His Lys Pro
    130                 135                 140                 
Gly Tyr Leu Ala Asn Asp Arg Leu Leu Pro Gln Arg Val Leu Glu Gln
145                 150                 155                 160 
His Lys Leu Thr Lys Glu Gln Trp Glu Glu Arg Ile Gln Asn Trp His
                165                 170                 175     
Glu Glu His Arg Gly Met Leu Arg Glu Asp Ser Met Met Glu Tyr Leu
            180                 185                 190         
Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Glu Ile
        195                 200                 205             
Lys Asn Lys Lys Gly Thr Glu Leu Trp Leu Gly Val Asp Ala Leu Gly
    210                 215                 220                 
Leu Asn Ile Tyr Glu His Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe
225                 230                 235                 240 
Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val
                245                 250                 255     
Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro
            260                 265                 270         
Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His
        275                 280                 285             
Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln
    290                 295                 300                 
Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg
305                 310                 315                 320 
Ala Gln Leu Glu Asn Glu Lys Lys Lys Arg Glu Ile Ala Glu Lys Glu
                325                 330                 335     
Lys Glu Arg Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys
            340                 345                 350         
Gln Ile Glu Glu Gln Thr Ile Lys Ala Gln Lys Glu Leu Glu Glu Gln
        355                 360                 365             
Thr Arg Lys Ala Leu Glu Leu Asp Gln Glu Arg Lys Arg Ala Lys Glu
    370                 375                 380                 
Glu Ala Glu Arg Leu Glu Lys Glu Arg Arg Ala Ala Glu Glu Ala Lys
385                 390                 395                 400 
Ser Ala Ile Ala Lys Gln Ala Ala Asp Gln Met Lys Asn Gln Glu Gln
                405                 410                 415     
Leu Ala Ala Glu Leu Ala Glu Phe Thr Ala Lys Ile Ala Leu Leu Glu
            420                 425                 430         
Glu Ala Lys Lys Lys Lys Glu Glu Glu Ala Thr Glu Trp Gln His Lys
        435                 440                 445             
Ala Phe Ala Ala Gln Glu Asp Leu Glu Lys Thr Lys Glu Glu Leu Lys
    450                 455                 460                 
Thr Val Met Ser Ala Pro Pro Pro Pro Pro Pro Pro Pro Val Ile Pro
465                 470                 475                 480 
Pro Thr Glu Asn Glu His Asp Glu His Asp Glu Asn Asn Ala Glu Ala
                485                 490                 495     
Ser Ala Glu Leu Ser Asn Glu Gly Val Met Asn His Arg Ser Glu Glu
            500                 505                 510         
Glu Arg Val Thr Glu Thr Gln Lys Asn Glu Arg Val Lys Lys Gln Leu
        515                 520                 525             
Gln Ala Leu Ser Ser Glu Leu Ala Gln Ala Arg Asp Glu Thr Lys Lys
    530                 535                 540                 
Thr Gln Asn Asp Val Leu His Ala Glu Asn Val Lys Ala Gly Arg Asp
545                 550                 555                 560 
Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg
                565                 570                 575     
Ile Asp Glu Phe Glu Ala Met
            580             


<210> 8625
<211> 586
<212> PRT
<213> Homo sapiens

<400> 8625
Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu
 1               5                  10                  15      
Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln
            20                  25                  30          
Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His
        35                  40                  45              
Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys
    50                  55                  60                  
Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe
65                  70                  75                  80  
Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp
                85                  90                  95      
Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser
            100                 105                 110         
Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr
        115                 120                 125             
Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser
    130                 135                 140                 
Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln
145                 150                 155                 160 
His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His
                165                 170                 175     
Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu
            180                 185                 190         
Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile
        195                 200                 205             
Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly
    210                 215                 220                 
Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe
225                 230                 235                 240 
Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val
                245                 250                 255     
Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro
            260                 265                 270         
Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His
        275                 280                 285             
Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln
    290                 295                 300                 
Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg
305                 310                 315                 320 
Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu
                325                 330                 335     
Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln
            340                 345                 350         
Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln
        355                 360                 365             
Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu
    370                 375                 380                 
Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys
385                 390                 395                 400 
Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln
                405                 410                 415     
Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu
            420                 425                 430         
Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg
        435                 440                 445             
Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His
    450                 455                 460                 
Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro
465                 470                 475                 480 
Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro
                485                 490                 495     
Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg
            500                 505                 510         
Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln
        515                 520                 525             
Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu
    530                 535                 540                 
Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln
545                 550                 555                 560 
Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr
                565                 570                 575     
Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu
            580                 585     


<210> 8626
<211> 161
<212> PRT
<213> Homo sapiens

<400> 8626
Met Asn Gln Phe Gly Pro Ser Ala Leu Ile Asn Leu Ser Asn Phe Ser
 1               5                  10                  15      
Ser Ile Lys Pro Glu Pro Ala Ser Thr Pro Pro Gln Gly Ser Met Ala
            20                  25                  30          
Asn Ser Thr Ala Val Val Lys Ile Pro Gly Thr Pro Gly Ala Gly Gly
        35                  40                  45              
Arg Leu Ser Pro Glu Asn Asn Gln Val Leu Thr Lys Lys Lys Leu Gln
    50                  55                  60                  
Asp Leu Val Arg Glu Val Asp Pro Asn Glu Gln Leu Asp Glu Asp Val
65                  70                  75                  80  
Glu Glu Met Leu Leu Gln Ile Ala Asp Asp Phe Ile Glu Ser Val Val
                85                  90                  95      
Thr Ala Ala Cys Gln Leu Ala Arg His Arg Lys Ser Ser Thr Leu Glu
            100                 105                 110         
Val Lys Asp Val Gln Leu His Leu Glu Arg Gln Trp Asn Met Trp Ile
        115                 120                 125             
Pro Gly Phe Gly Ser Glu Glu Ile Arg Pro Tyr Lys Lys Ala Cys Thr
    130                 135                 140                 
Thr Glu Ala His Lys Gln Arg Met Ala Leu Ile Arg Lys Thr Thr Lys
145                 150                 155                 160 
Lys
    


<210> 8627
<211> 755
<212> PRT
<213> Homo sapiens

<400> 8627
Met Leu Asp Cys Ser Asp Tyr Val Leu Asp Ser Arg Met Asn Asn Pro
 1               5                  10                  15      
Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp Gly Asn Thr Gly
            20                  25                  30          
Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro Val Pro Val Gly
        35                  40                  45              
Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu Gly His Leu His
    50                  55                  60                  
Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala Ala Gln Ser Leu
65                  70                  75                  80  
Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp Ser Gln Gln Pro
                85                  90                  95      
Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala Ile Pro Gln Thr
            100                 105                 110         
Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu Thr Leu Thr Pro
        115                 120                 125             
Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala Gln Ala Gln Leu
    130                 135                 140                 
Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln Gln His Ser Ala
145                 150                 155                 160 
Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro Met Thr Gln Ile
                165                 170                 175     
Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu Gln Gln Leu Gln
            180                 185                 190         
Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe Val Leu Val His
        195                 200                 205             
Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile Ser Gln Thr Pro
    210                 215                 220                 
Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu Leu Thr Gln Leu
225                 230                 235                 240 
Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln Pro Ser Ile Thr
                245                 250                 255     
Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile Ala Ala Thr Pro
            260                 265                 270         
Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys Arg Ile Asp Thr
        275                 280                 285             
Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala
    290                 295                 300                 
Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp
305                 310                 315                 320 
Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr
                325                 330                 335     
Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys
            340                 345                 350         
Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu Asn Leu
        355                 360                 365             
Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu Asn Ser Pro Gly
    370                 375                 380                 
Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr
385                 390                 395                 400 
Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro
                405                 410                 415     
Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys
            420                 425                 430         
Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg
        435                 440                 445             
Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser Pro Ile Lys Ala
    450                 455                 460                 
Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr Pro Ser Leu Val
465                 470                 475                 480 
Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro Val Leu Pro Leu
                485                 490                 495     
Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly Thr Ser Asp Thr
            500                 505                 510         
Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala Pro Pro Ala Ser
        515                 520                 525             
Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro Ser Ala Ser Ala
    530                 535                 540                 
Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser Thr Thr Gln Thr
545                 550                 555                 560 
Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser Gln Val Met Val
                565                 570                 575     
Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala Leu Gln Gly Ala
            580                 585                 590         
Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met Ala Ala Ala Ala
        595                 600                 605             
Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe Ala Ala Gly Gly
    610                 615                 620                 
Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly Ala Leu Ser Pro
625                 630                 635                 640 
Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln Ala Leu Ala Ser
                645                 650                 655     
Gly Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala Thr Gly Asn Leu Val
            660                 665                 670         
Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val Thr Ala Pro Leu Phe
        675                 680                 685             
Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser Asn Pro Val Ser Leu
    690                 695                 700                 
Val Ser Ala Ala Ala Ala Ser Ala Gly Asn Ser Ala Pro Val Ala Ser
705                 710                 715                 720 
Leu His Ala Thr Ser Thr Ser Ala Glu Ser Ile Gln Asn Ser Leu Phe
                725                 730                 735     
Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr Thr Thr Thr Ala Ser
            740                 745                 750         
Lys Ala Gln
        755 


<210> 8628
<211> 743
<212> PRT
<213> Homo sapiens

<400> 8628
Met Asn Asn Pro Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp
 1               5                  10                  15      
Gly Asn Thr Gly Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro
            20                  25                  30          
Val Pro Val Gly Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu
        35                  40                  45              
Gly His Leu His Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala
    50                  55                  60                  
Ala Gln Ser Leu Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp
65                  70                  75                  80  
Ser Gln Gln Pro Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala
                85                  90                  95      
Ile Pro Gln Thr Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu
            100                 105                 110         
Thr Leu Thr Pro Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala
        115                 120                 125             
Gln Ala Gln Leu Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln
    130                 135                 140                 
Gln His Ser Ala Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro
145                 150                 155                 160 
Met Thr Gln Ile Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu
                165                 170                 175     
Gln Gln Leu Gln Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe
            180                 185                 190         
Val Leu Val His Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile
        195                 200                 205             
Ser Gln Thr Pro Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu
    210                 215                 220                 
Leu Thr Gln Leu Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln
225                 230                 235                 240 
Pro Ser Ile Thr Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile
                245                 250                 255     
Ala Ala Thr Pro Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys
            260                 265                 270         
Arg Ile Asp Thr Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu
        275                 280                 285             
Glu Gln Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe
    290                 295                 300                 
Thr Gln Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp
305                 310                 315                 320 
Phe Ser Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe
                325                 330                 335     
Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp
            340                 345                 350         
Ala Glu Asn Leu Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu
        355                 360                 365             
Asn Ser Pro Gly Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr
    370                 375                 380                 
Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu
385                 390                 395                 400 
Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu
                405                 410                 415     
Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln
            420                 425                 430         
Lys Glu Lys Arg Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser
        435                 440                 445             
Pro Ile Lys Ala Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr
    450                 455                 460                 
Pro Ser Leu Val Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro
465                 470                 475                 480 
Val Leu Pro Leu Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly
                485                 490                 495     
Thr Ser Asp Thr Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala
            500                 505                 510         
Pro Pro Ala Ser Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro
        515                 520                 525             
Ser Ala Ser Ala Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser
    530                 535                 540                 
Thr Thr Gln Thr Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser
545                 550                 555                 560 
Gln Val Met Val Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala
                565                 570                 575     
Leu Gln Gly Ala Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met
            580                 585                 590         
Ala Ala Ala Ala Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe
        595                 600                 605             
Ala Ala Gly Gly Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly
    610                 615                 620                 
Ala Leu Ser Pro Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln
625                 630                 635                 640 
Ala Leu Ala Ser Gly Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala Thr
                645                 650                 655     
Gly Asn Leu Val Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val Thr
            660                 665                 670         
Ala Pro Leu Phe Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser Asn
        675                 680                 685             
Pro Val Ser Leu Val Ser Ala Ala Ala Ala Ser Ala Gly Asn Ser Ala
    690                 695                 700                 
Pro Val Ala Ser Leu His Ala Thr Ser Thr Ser Ala Glu Ser Ile Gln
705                 710                 715                 720 
Asn Ser Leu Phe Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr Thr
                725                 730                 735     
Thr Thr Ala Ser Lys Ala Gln
            740             


<210> 8629
<211> 740
<212> PRT
<213> Homo sapiens

<400> 8629
Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn
 1               5                  10                  15      
Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg
            20                  25                  30          
Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu
        35                  40                  45              
Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu
    50                  55                  60                  
Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp
65                  70                  75                  80  
Lys Gln Arg Pro Leu Gln Glu Leu Leu Pro Glu Thr Lys Leu Cys Ile
                85                  90                  95      
Cys Gly His Ser Ser Gly Asp Gly His Pro His Asn Thr Phe Ala Val
            100                 105                 110         
Pro Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln
        115                 120                 125             
Met Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln
    130                 135                 140                 
Ala Leu Leu Gln Gln Gln Gln Ala Val Met Leu Gln Gln Gln Gln Leu
145                 150                 155                 160 
Gln Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu His Leu Gln Leu Leu
                165                 170                 175     
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            180                 185                 190         
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        195                 200                 205             
Gln Gln Gln Gln Gln Gln Gln Gln His Pro Gly Lys Gln Ala Lys Glu
    210                 215                 220                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Ala Ala Gln Gln Leu
225                 230                 235                 240 
Val Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln Gln
                245                 250                 255     
His Leu Leu Ser Leu Gln Arg Gln Gly Leu Ile Ser Ile Pro Pro Gly
            260                 265                 270         
Gln Ala Ala Leu Pro Val Gln Ser Leu Pro Gln Ala Gly Leu Ser Pro
        275                 280                 285             
Ala Glu Ile Gln Gln Leu Trp Lys Glu Val Thr Gly Val His Ser Met
    290                 295                 300                 
Glu Asp Asn Gly Ile Lys His Gly Gly Leu Asp Leu Thr Thr Asn Asn
305                 310                 315                 320 
Ser Ser Ser Thr Thr Ser Ser Asn Thr Ser Lys Ala Ser Pro Pro Ile
                325                 330                 335     
Thr His His Ser Ile Val Asn Gly Gln Ser Ser Val Leu Ser Ala Arg
            340                 345                 350         
Arg Asp Ser Ser Ser His Glu Glu Thr Gly Ala Ser His Thr Leu Tyr
        355                 360                 365             
Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ser Ile Cys Glu Asp
    370                 375                 380                 
Phe Gly Gln Phe Leu Lys His Leu Asn Asn Glu His Ala Leu Asp Asp
385                 390                 395                 400 
Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu
                405                 410                 415     
Glu Ile Gln Leu Ser Lys Glu Arg Glu Arg Leu Gln Ala Met Met Thr
            420                 425                 430         
His Leu His Met Arg Pro Ser Glu Pro Lys Pro Ser Pro Lys Pro Val
        435                 440                 445             
Asn Leu Val Ser Ser Val Thr Met Ser Lys Asn Met Leu Glu Thr Ser
    450                 455                 460                 
Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr Pro Thr Ala Pro Val Thr
465                 470                 475                 480 
Pro Ile Thr Gln Gly Pro Ser Val Ile Thr Pro Ala Ser Val Pro Asn
                485                 490                 495     
Val Gly Ala Ile Arg Arg Arg His Ser Asp Lys Tyr Asn Ile Pro Met
            500                 505                 510         
Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe Tyr Lys Asn Ala Asp Val
        515                 520                 525             
Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Gln Ala Ile Met Glu
    530                 535                 540                 
Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr Ser Trp Phe Thr
545                 550                 555                 560 
Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala
                565                 570                 575     
Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn
            580                 585                 590         
Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Tyr Gln Lys Arg
        595                 600                 605             
Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr Leu Val Lys Asn Ile Pro
    610                 615                 620                 
Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn Ala Ser Leu Gln Ala Ala
625                 630                 635                 640 
Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser Asn Pro Gly Leu Ile Asn
                645                 650                 655     
Asn Ala Ser Ser Gly Leu Leu Gln Ala Val His Glu Asp Leu Asn Gly
            660                 665                 670         
Ser Leu Asp His Ile Asp Ser Asn Gly Asn Ser Ser Pro Gly Cys Ser
        675                 680                 685             
Pro Gln Pro His Ile His Ser Ile His Val Lys Glu Glu Pro Val Ile
    690                 695                 700                 
Ala Glu Asp Glu Asp Cys Pro Met Ser Leu Val Thr Thr Ala Asn His
705                 710                 715                 720 
Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile Glu Glu Glu Pro Leu Ser
                725                 730                 735     
Glu Asp Leu Glu
            740 


<210> 8630
<211> 168
<212> PRT
<213> Homo sapiens

<400> 8630
Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn
 1               5                  10                  15      
Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg
            20                  25                  30          
Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu
        35                  40                  45              
Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu
    50                  55                  60                  
Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp
65                  70                  75                  80  
Lys Gln Arg Pro Leu Gln Glu Leu Leu Pro Glu Thr Lys Leu Cys Ile
                85                  90                  95      
Cys Gly His Ser Ser Gly Asp Gly His Pro His Asn Thr Phe Ala Val
            100                 105                 110         
Pro Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln
        115                 120                 125             
Met Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln
    130                 135                 140                 
Ala Leu Leu Gln Gln Gln Gln Ala Val Met Leu Gln Gln Val Met Trp
145                 150                 155                 160 
Val Thr Cys Phe Gly Val Leu Ala
                165             


<210> 8631
<211> 740
<212> PRT
<213> Homo sapiens

<400> 8631
Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn
 1               5                  10                  15      
Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg
            20                  25                  30          
Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu
        35                  40                  45              
Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu
    50                  55                  60                  
Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp
65                  70                  75                  80  
Lys Gln Arg Pro Leu Gln Glu Leu Leu Pro Glu Thr Lys Leu Cys Ile
                85                  90                  95      
Cys Gly His Ser Ser Gly Asp Gly His Pro His Asn Thr Phe Ala Val
            100                 105                 110         
Pro Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln
        115                 120                 125             
Met Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln
    130                 135                 140                 
Ala Leu Leu Gln Gln Gln Gln Ala Val Met Leu Gln Gln Gln Gln Leu
145                 150                 155                 160 
Gln Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu His Leu Gln Leu Leu
                165                 170                 175     
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            180                 185                 190         
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        195                 200                 205             
Gln Gln Gln Gln Gln Gln Gln Gln His Pro Gly Lys Gln Ala Lys Glu
    210                 215                 220                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Ala Ala Gln Gln Leu
225                 230                 235                 240 
Val Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln Gln
                245                 250                 255     
His Leu Leu Ser Leu Gln Arg Gln Gly Leu Ile Ser Ile Pro Pro Gly
            260                 265                 270         
Gln Ala Ala Leu Pro Val Gln Ser Leu Pro Gln Ala Gly Leu Ser Pro
        275                 280                 285             
Ala Glu Ile Gln Gln Leu Trp Lys Glu Val Thr Gly Val His Ser Met
    290                 295                 300                 
Glu Asp Asn Gly Ile Lys His Gly Gly Leu Asp Leu Thr Thr Asn Asn
305                 310                 315                 320 
Ser Ser Ser Thr Thr Ser Ser Asn Thr Ser Lys Ala Ser Pro Pro Ile
                325                 330                 335     
Thr His His Ser Ile Val Asn Gly Gln Ser Ser Val Leu Ser Ala Arg
            340                 345                 350         
Arg Asp Ser Ser Ser His Glu Glu Thr Gly Ala Ser His Thr Leu Tyr
        355                 360                 365             
Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ser Ile Cys Glu Asp
    370                 375                 380                 
Phe Gly Gln Phe Leu Lys His Leu Asn Asn Glu His Ala Leu Asp Asp
385                 390                 395                 400 
Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu
                405                 410                 415     
Glu Ile Gln Leu Ser Lys Glu Arg Glu Arg Leu Gln Ala Met Met Thr
            420                 425                 430         
His Leu His Met Arg Pro Ser Glu Pro Lys Pro Ser Pro Lys Pro Leu
        435                 440                 445             
Asn Leu Val Ser Ser Val Thr Met Ser Lys Asn Met Leu Glu Thr Ser
    450                 455                 460                 
Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr Pro Thr Ala Pro Val Thr
465                 470                 475                 480 
Pro Ile Thr Gln Gly Pro Ser Val Ile Thr Pro Ala Ser Val Pro Asn
                485                 490                 495     
Val Gly Ala Ile Arg Arg Arg His Ser Asp Lys Tyr Asn Ile Pro Met
            500                 505                 510         
Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe Tyr Lys Asn Ala Asp Val
        515                 520                 525             
Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Gln Ala Ile Met Glu
    530                 535                 540                 
Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr Ser Trp Phe Thr
545                 550                 555                 560 
Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala
                565                 570                 575     
Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn
            580                 585                 590         
Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Tyr Gln Lys Arg
        595                 600                 605             
Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr Leu Val Lys Asn Ile Pro
    610                 615                 620                 
Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn Ala Ser Leu Gln Ala Ala
625                 630                 635                 640 
Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser Asn Pro Gly Leu Ile Asn
                645                 650                 655     
Asn Ala Ser Ser Gly Leu Leu Gln Ala Val His Glu Asp Leu Asn Gly
            660                 665                 670         
Ser Leu Asp His Ile Asp Ser Asn Gly Asn Ser Ser Pro Gly Cys Ser
        675                 680                 685             
Pro Gln Pro His Ile His Ser Ile His Val Lys Glu Glu Pro Val Ile
    690                 695                 700                 
Ala Glu Asp Glu Asp Cys Pro Met Ser Leu Val Thr Thr Ala Asn His
705                 710                 715                 720 
Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile Glu Glu Glu Pro Leu Ser
                725                 730                 735     
Glu Asp Leu Glu
            740 


<210> 8632
<211> 715
<212> PRT
<213> Homo sapiens

<400> 8632
Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn
 1               5                  10                  15      
Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg
            20                  25                  30          
Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu
        35                  40                  45              
Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu
    50                  55                  60                  
Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp
65                  70                  75                  80  
Lys Gln Arg Pro Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro
                85                  90                  95      
Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val
            100                 105                 110         
Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val
        115                 120                 125             
Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu
    130                 135                 140                 
Gln Leu His Leu Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln
145                 150                 155                 160 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
                165                 170                 175     
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His
            180                 185                 190         
Pro Gly Lys Gln Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln
        195                 200                 205             
Gln Leu Ala Ala Gln Gln Leu Val Phe Gln Gln Gln Leu Leu Gln Met
    210                 215                 220                 
Gln Gln Leu Gln Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly
225                 230                 235                 240 
Leu Ile Ser Ile Pro Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu
                245                 250                 255     
Pro Gln Ala Gly Leu Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu
            260                 265                 270         
Val Thr Gly Val His Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly
        275                 280                 285             
Leu Asp Leu Thr Thr Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr
    290                 295                 300                 
Ser Lys Ala Ser Pro Pro Ile Thr His His Ser Ile Val Asn Gly Gln
305                 310                 315                 320 
Ser Ser Val Leu Ser Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr
                325                 330                 335     
Gly Ala Ser His Thr Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly
            340                 345                 350         
Cys Glu Ser Ile Cys Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn
        355                 360                 365             
Asn Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln
    370                 375                 380                 
Met Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu
385                 390                 395                 400 
Arg Leu Gln Ala Met Met Thr His Leu His Met Arg Pro Ser Glu Pro
                405                 410                 415     
Lys Pro Ser Pro Lys Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser
            420                 425                 430         
Lys Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr
        435                 440                 445             
Thr Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile
    450                 455                 460                 
Thr Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser
465                 470                 475                 480 
Asp Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu
                485                 490                 495     
Phe Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu
            500                 505                 510         
Ile Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn
        515                 520                 525             
Glu Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn
    530                 535                 540                 
Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys
545                 550                 555                 560 
Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp
                565                 570                 575     
Glu Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro
            580                 585                 590         
Thr Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu
        595                 600                 605             
Asn Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu
    610                 615                 620                 
Ser Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala
625                 630                 635                 640 
Val His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly
                645                 650                 655     
Asn Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His
            660                 665                 670         
Val Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser
        675                 680                 685             
Leu Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu
    690                 695                 700                 
Ile Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu
705                 710                 715 


<210> 8633
<211> 67
<212> PRT
<213> Homo sapiens

<400> 8633
Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn
 1               5                  10                  15      
Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg
            20                  25                  30          
Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu
        35                  40                  45              
Leu Leu His Leu Gln Gln Gln Gln Glu Asp Val Val Ser Tyr Thr Gln
    50                  55                  60                  
Val Ile Cys
65          


<210> 8634
<211> 286
<212> PRT
<213> Homo sapiens

<400> 8634
Met Met Ala Thr Pro Asn Gln Thr Ala Cys Asn Ala Glu Ser Pro Val
 1               5                  10                  15      
Ala Leu Glu Glu Ala Lys Thr Ser Gly Ala Pro Gly Ser Pro Gln Thr
            20                  25                  30          
Pro Pro Glu Arg His Asp Ser Gly Gly Ser Leu Pro Leu Thr Pro Arg
        35                  40                  45              
Met Glu Ser His Ser Glu Asp Glu Asp Leu Ala Gly Ala Val Gly Gly
    50                  55                  60                  
Leu Gly Trp Asn Ser Arg Ser Pro Arg Thr Gln Ser Pro Gly Gly Cys
65                  70                  75                  80  
Ser Ala Glu Ala Val Leu Ala Arg Lys Lys His Arg Arg Arg Pro Ser
                85                  90                  95      
Lys Arg Lys Arg His Trp Arg Pro Tyr Leu Glu Leu Ser Trp Ala Glu
            100                 105                 110         
Lys Gln Gln Arg Asp Glu Arg Gln Ser Gln Arg Ala Ser Arg Val Arg
        115                 120                 125             
Glu Glu Met Phe Ala Lys Gly Gln Pro Val Ala Pro Tyr Asn Thr Thr
    130                 135                 140                 
Gln Phe Leu Met Asn Asp Arg Asp Pro Glu Glu Pro Asn Leu Asp Val
145                 150                 155                 160 
Pro His Gly Ile Ser His Pro Gly Ser Ser Gly Glu Ser Glu Ala Gly
                165                 170                 175     
Asp Ser Asp Gly Arg Gly Arg Ala His Gly Glu Phe Gln Arg Lys Asp
            180                 185                 190         
Phe Ser Glu Thr Tyr Glu Arg Phe His Thr Glu Ser Leu Gln Gly Arg
        195                 200                 205             
Ser Lys Gln Glu Leu Val Arg Asp Tyr Leu Glu Leu Glu Lys Arg Leu
    210                 215                 220                 
Ser Gln Ala Glu Glu Glu Thr Arg Arg Leu Gln Gln Leu Gln Ala Cys
225                 230                 235                 240 
Thr Gly Gln Gln Ser Cys Arg Gln Val Glu Glu Leu Ala Ala Glu Val
                245                 250                 255     
Gln Arg Leu Arg Thr Glu Asn Gln Arg Leu Arg Gln Glu Asn Gln Met
            260                 265                 270         
Trp Asn Arg Glu Gly Cys Arg Cys Asp Glu Glu Pro Gly Thr
        275                 280                 285     


<210> 8635
<211> 419
<212> PRT
<213> Homo sapiens

<400> 8635
Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe
 1               5                  10                  15      
Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe
            20                  25                  30          
Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu
        35                  40                  45              
Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg
    50                  55                  60                  
Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu
65                  70                  75                  80  
Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys
                85                  90                  95      
Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln
            100                 105                 110         
Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe
        115                 120                 125             
Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu
    130                 135                 140                 
Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn
145                 150                 155                 160 
Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu
                165                 170                 175     
Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser
            180                 185                 190         
Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys
        195                 200                 205             
Val Ser Met Asp Asn Arg Leu Met Glu Leu Phe Pro Ala Asn Lys Gln
    210                 215                 220                 
Ser Val Glu His Phe Thr Lys Tyr Phe Thr Glu Ala Gly Leu Lys Glu
225                 230                 235                 240 
Leu Ser Glu Tyr Val Arg Asn Gln Gln Thr Ile Gly Ala Arg Lys Glu
                245                 250                 255     
Leu Gln Lys Glu Leu Gln Glu Gln Met Ser Arg Gly Asp Pro Phe Lys
            260                 265                 270         
Asp Ile Ile Leu Tyr Val Lys Glu Glu Met Lys Lys Asn Asn Ile Pro
        275                 280                 285             
Glu Pro Val Val Ile Gly Ile Val Trp Ser Ser Val Met Ser Thr Val
    290                 295                 300                 
Glu Trp Asn Lys Lys Glu Glu Leu Val Ala Glu Gln Ala Ile Lys His
305                 310                 315                 320 
Leu Lys Gln Tyr Ser Pro Leu Leu Ala Ala Phe Thr Thr Gln Gly Gln
                325                 330                 335     
Ser Glu Leu Thr Leu Leu Leu Lys Ile Gln Glu Tyr Cys Tyr Asp Asn
            340                 345                 350         
Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val Leu Phe Tyr Lys
        355                 360                 365             
Ala Glu Val Leu Ser Glu Glu Pro Ile Leu Lys Trp Tyr Lys Asp Ala
    370                 375                 380                 
His Val Ala Lys Gly Lys Ser Val Phe Leu Glu Gln Met Lys Lys Phe
385                 390                 395                 400 
Val Glu Trp Leu Lys Asn Ala Glu Glu Glu Ser Glu Ser Glu Ala Glu
                405                 410                 415     
Glu Gly Asp
            


<210> 8636
<211> 356
<212> PRT
<213> Homo sapiens

<400> 8636
Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe
 1               5                  10                  15      
Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe
            20                  25                  30          
Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu
        35                  40                  45              
Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg
    50                  55                  60                  
Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu
65                  70                  75                  80  
Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys
                85                  90                  95      
Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln
            100                 105                 110         
Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe
        115                 120                 125             
Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu
    130                 135                 140                 
Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn
145                 150                 155                 160 
Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu
                165                 170                 175     
Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser
            180                 185                 190         
Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys
        195                 200                 205             
Val Ser Met Asp Asn Arg Leu Met Glu Leu Phe Pro Ala Asn Lys Gln
    210                 215                 220                 
Ser Val Glu His Phe Thr Lys Tyr Phe Thr Glu Ala Gly Leu Lys Glu
225                 230                 235                 240 
Leu Ser Glu Tyr Val Arg Asn Gln Gln Thr Ile Gly Ala Arg Lys Glu
                245                 250                 255     
Leu Gln Lys Glu Leu Gln Glu Gln Met Ser Arg Gly Asp Pro Phe Lys
            260                 265                 270         
Asp Ser Glu Leu Thr Leu Leu Leu Lys Ile Gln Glu Tyr Cys Tyr Asp
        275                 280                 285             
Asn Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val Leu Phe Tyr
    290                 295                 300                 
Lys Ala Glu Val Leu Ser Glu Glu Pro Ile Leu Lys Trp Tyr Lys Asp
305                 310                 315                 320 
Ala His Val Ala Lys Gly Lys Ser Val Phe Leu Glu Gln Met Lys Lys
                325                 330                 335     
Phe Val Glu Trp Leu Lys Asn Ala Glu Glu Glu Ser Glu Ser Glu Ala
            340                 345                 350         
Glu Glu Gly Asp
        355     


<210> 8637
<211> 234
<212> PRT
<213> Homo sapiens

<400> 8637
Met Leu Thr Gly Val Leu Leu Ala Asn Gly Thr Leu Asn Ala Ser Ile
 1               5                  10                  15      
Leu Asn Ser Leu Tyr Asn Glu Asn Leu Val Lys Glu Gly Val Ser Ala
            20                  25                  30          
Ala Phe Ala Val Lys Leu Phe Lys Ser Trp Ile Asn Glu Lys Asp Ile
        35                  40                  45              
Asn Ala Val Ala Ala Ser Leu Arg Lys Val Ser Met Asp Asn Arg Leu
    50                  55                  60                  
Met Glu Leu Phe Pro Ala Asn Lys Gln Ser Val Glu His Phe Thr Lys
65                  70                  75                  80  
Tyr Phe Thr Glu Ala Gly Leu Lys Glu Leu Ser Glu Tyr Val Arg Asn
                85                  90                  95      
Gln Gln Thr Ile Gly Ala Arg Lys Glu Leu Gln Lys Glu Leu Gln Glu
            100                 105                 110         
Gln Met Ser Arg Gly Asp Pro Phe Lys Asp Ile Ile Leu Tyr Val Lys
        115                 120                 125             
Glu Glu Met Lys Lys Asn Asn Ile Pro Glu Pro Val Val Ile Gly Ile
    130                 135                 140                 
Val Trp Ser Ser Val Met Ser Thr Val Glu Trp Asn Lys Lys Glu Glu
145                 150                 155                 160 
Leu Val Ala Glu Gln Ala Ile Lys His Leu Lys Gln Tyr Ser Pro Leu
                165                 170                 175     
Leu Ala Ala Phe Thr Thr Gln Ala Glu Val Leu Ser Glu Glu Pro Ile
            180                 185                 190         
Leu Lys Trp Tyr Lys Asp Ala His Val Ala Lys Gly Lys Ser Val Phe
        195                 200                 205             
Leu Glu Gln Met Lys Lys Phe Val Glu Trp Leu Lys Asn Ala Glu Glu
    210                 215                 220                 
Glu Ser Glu Ser Glu Ala Glu Glu Gly Asp
225                 230                 


<210> 8638
<211> 488
<212> PRT
<213> Homo sapiens

<400> 8638
Met Glu Asn Leu Thr Lys His Ser Ile Glu Cys Ser Ser Phe Arg Gly
 1               5                  10                  15      
Asp Trp Glu Cys Lys Asn Gln Phe Glu Arg Lys Gln Gly Ser Gln Glu
            20                  25                  30          
Gly His Phe Ser Glu Met Ile Phe Thr Pro Glu Asp Met Pro Thr Phe
        35                  40                  45              
Ser Ile Gln His Gln Arg Ile His Thr Asp Glu Lys Leu Leu Glu Cys
    50                  55                  60                  
Lys Glu Cys Gly Lys Asp Phe Ser Phe Val Ser Val Leu Val Arg His
65                  70                  75                  80  
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly
                85                  90                  95      
Lys Ala Phe Gly Ser Gly Ala Asn Leu Ala Tyr His Gln Arg Ile His
            100                 105                 110         
Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Gly
        115                 120                 125             
Ser Gly Ser Asn Leu Thr His His Gln Arg Ile His Thr Gly Glu Lys
    130                 135                 140                 
Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Phe Gly Ser Gly
145                 150                 155                 160 
Leu Ile Arg His Gln Ile Ile His Ser Gly Glu Lys Pro Tyr Glu Cys
                165                 170                 175     
Lys Glu Cys Gly Lys Ser Phe Ser Phe Glu Ser Ala Leu Ile Arg His
            180                 185                 190         
His Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Asp Cys Gly
        195                 200                 205             
Lys Ala Phe Gly Ser Gly Ser Asn Leu Thr Gln His Arg Arg Ile His
    210                 215                 220                 
Thr Gly Glu Lys Pro Tyr Glu Cys Lys Ala Cys Gly Met Ala Phe Ser
225                 230                 235                 240 
Ser Gly Ser Ala Leu Thr Arg His Gln Arg Ile His Thr Gly Glu Lys
                245                 250                 255     
Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ala Phe Ser Phe Gly Ser Ala
            260                 265                 270         
Leu Thr Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys
        275                 280                 285             
Lys Glu Cys Gly Lys Ala Phe Asn Ser Gly Ser Asp Leu Thr Gln His
    290                 295                 300                 
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Glu
305                 310                 315                 320 
Lys Ala Phe Arg Ser Gly Ser Lys Leu Ile Gln His Gln Arg Met His
                325                 330                 335     
Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Ser
            340                 345                 350         
Ser Gly Ser Asp Leu Thr Gln His His Arg Ile His Thr Gly Glu Lys
        355                 360                 365             
Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Gly Ser Gly Ser Lys
    370                 375                 380                 
Leu Ile Gln His Gln Leu Ile His Thr Gly Glu Arg Pro Tyr Glu Cys
385                 390                 395                 400 
Lys Glu Cys Gly Lys Ser Phe Ser Ser Gly Ser Ala Leu Asn Arg His
                405                 410                 415     
Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly
            420                 425                 430         
Lys Ala Phe Tyr Ser Gly Ser Ser Leu Thr Gln His Gln Arg Ile His
        435                 440                 445             
Thr Gly Glu Lys Leu Tyr Glu Cys Lys Asn Cys Gly Lys Ala Tyr Gly
    450                 455                 460                 
Arg Asp Ser Glu Phe Gln Gln His Lys Lys Ser His Asn Gly Lys Lys
465                 470                 475                 480 
Leu Cys Glu Leu Glu Thr Ile Asn
                485             


<210> 8639
<211> 194
<212> PRT
<213> Homo sapiens

<400> 8639
Met Glu Asn Phe Thr Ala Leu Phe Gly Ala Gln Ala Asp Pro Pro Pro
 1               5                  10                  15      
Pro Pro Thr Ala Leu Gly Phe Gly Pro Gly Lys Pro Pro Pro Pro Pro
            20                  25                  30          
Pro Pro Pro Ala Gly Gly Gly Pro Gly Thr Ala Pro Pro Pro Thr Ala
        35                  40                  45              
Ala Thr Ala Pro Pro Gly Ala Asp Lys Ser Gly Ala Gly Cys Gly Pro
    50                  55                  60                  
Phe Tyr Leu Met Arg Glu Leu Pro Gly Ser Thr Glu Leu Thr Gly Ser
65                  70                  75                  80  
Thr Asn Leu Ile Thr His Tyr Asn Leu Glu Gln Ala Tyr Asn Lys Phe
                85                  90                  95      
Cys Gly Lys Lys Val Lys Glu Lys Leu Ser Asn Phe Leu Pro Asp Leu
            100                 105                 110         
Pro Gly Met Ile Asp Leu Pro Gly Ser His Asp Asn Ser Ser Leu Arg
        115                 120                 125             
Ser Leu Ile Glu Lys Pro Pro Ile Leu Ser Ser Ser Phe Asn Pro Ile
    130                 135                 140                 
Thr Gly Thr Met Leu Ala Gly Phe Arg Leu His Thr Gly Pro Leu Pro
145                 150                 155                 160 
Glu Gln Cys Arg Leu Met His Ile Gln Pro Pro Lys Lys Lys Asn Lys
                165                 170                 175     
His Lys His Lys Gln Ser Arg Thr Gln Asp Pro Val Pro Pro Gly Lys
            180                 185                 190         
Pro Ser
        


<210> 8640
<211> 261
<212> PRT
<213> Homo sapiens

<400> 8640
Met Glu Asn Phe Ser Leu Leu Ser Ile Ser Gly Pro Pro Ile Ser Ser
 1               5                  10                  15      
Ser Ala Leu Ser Ala Phe Pro Asp Ile Met Phe Ser Arg Ala Thr Ser
            20                  25                  30          
Leu Pro Asp Ile Ala Lys Thr Ala Val Pro Thr Glu Ala Ser Ser Pro
        35                  40                  45              
Ala Gln Ala Leu Pro Pro Gln Tyr Gln Ser Ile Ile Val Arg Gln Gly
    50                  55                  60                  
Ile Gln Asn Thr Val Leu Ser Pro Asp Cys Ser Leu Gly Asp Thr Gln
65                  70                  75                  80  
His Gly Glu Lys Leu Arg Arg Asn Cys Thr Ile Tyr Arg Pro Trp Phe
                85                  90                  95      
Ser Pro Tyr Ser Tyr Phe Val Cys Ala Asp Lys Glu Ser Gln Leu Glu
            100                 105                 110         
Ala Tyr Asp Phe Pro Glu Val Gln Gln Asp Glu Gly Lys Trp Asp Asn
        115                 120                 125             
Cys Leu Ser Glu Asp Met Ala Glu Asn Ile Cys Ser Ser Ser Ser Ser
    130                 135                 140                 
Pro Glu Asn Thr Cys Pro Arg Glu Ala Thr Lys Lys Ser Arg His Gly
145                 150                 155                 160 
Leu Asp Ser Ile Thr Ser Gln Asp Ile Leu Met Ala Ser Arg Trp His
                165                 170                 175     
Pro Ala Gln Gln Asn Gly Tyr Lys Cys Val Ala Cys Cys Arg Met Tyr
            180                 185                 190         
Pro Thr Leu Asp Phe Leu Lys Ser His Ile Lys Arg Gly Phe Arg Glu
        195                 200                 205             
Gly Phe Ser Cys Lys Val Tyr Tyr His Lys Leu Lys Ala Leu Trp Ser
    210                 215                 220                 
Lys Glu Gln Lys Ala Arg Leu Gly Asp Arg Leu Ser Ser Gly Ser Cys
225                 230                 235                 240 
Gln Ala Phe Asn Ser Pro Ala Glu His Leu Arg Gln Ile Gly Gly Glu
                245                 250                 255     
Ala Tyr Leu Cys Leu
            260     


<210> 8641
<211> 471
<212> PRT
<213> Homo sapiens

<400> 8641
Met Asp Ser Ser Cys His Asn Ala Thr Thr Lys Met Leu Ala Thr Ala
 1               5                  10                  15      
Pro Ala Arg Gly Asn Met Met Ser Thr Ser Lys Pro Leu Ala Phe Ser
            20                  25                  30          
Ile Glu Arg Ile Met Ala Arg Thr Pro Glu Pro Lys Ala Leu Pro Val
        35                  40                  45              
Pro His Phe Leu Gln Gly Ala Leu Pro Lys Gly Glu Pro Lys His Ser
    50                  55                  60                  
Leu His Leu Asn Ser Ser Ile Pro Cys Met Ile Pro Phe Val Pro Val
65                  70                  75                  80  
Ala Tyr Asp Thr Ser Pro Lys Ala Gly Val Thr Gly Ser Glu Pro Arg
                85                  90                  95      
Lys Ala Ser Leu Glu Ala Pro Ala Ala Pro Ala Ala Val Pro Ser Ala
            100                 105                 110         
Pro Ala Phe Ser Cys Ser Asp Leu Leu Asn Cys Ala Leu Ser Leu Lys
        115                 120                 125             
Gly Asp Leu Ala Arg Asp Ala Leu Pro Leu Gln Gln Tyr Lys Leu Val
    130                 135                 140                 
Arg Pro Arg Val Val Asn His Ser Ser Phe His Ala Met Gly Ala Leu
145                 150                 155                 160 
Cys Tyr Leu Asn Arg Gly Asp Gly Pro Cys His Pro Ala Ala Gly Val
                165                 170                 175     
Asn Ile His Pro Val Ala Ser Tyr Phe Leu Ser Ser Pro Leu His Pro
            180                 185                 190         
Gln Pro Lys Thr Tyr Leu Ala Glu Arg Asn Lys Leu Val Val Pro Ala
        195                 200                 205             
Val Glu Lys Tyr Pro Ser Gly Val Ala Phe Lys Asp Leu Ser Gln Ala
    210                 215                 220                 
Gln Leu Gln His Tyr Met Lys Glu Ser Ala Gln Leu Leu Ser Glu Lys
225                 230                 235                 240 
Ile Ala Phe Lys Thr Ser Asp Phe Ser Arg Gly Ser Pro Asn Ala Lys
                245                 250                 255     
Pro Lys Val Phe Thr Cys Glu Val Phe Asn Ala His Tyr Asn Leu Thr
            260                 265                 270         
Arg His Met Pro Val His Thr Gly Ala Arg Pro Phe Val Cys Lys Val
        275                 280                 285             
Cys Gly Lys Gly Phe Arg Gln Ala Ser Thr Leu Cys Arg His Lys Ile
    290                 295                 300                 
Ile His Thr Gln Glu Lys Pro His Lys Cys Asn Gln Cys Gly Lys Ala
305                 310                 315                 320 
Phe Asn Arg Ser Ser Thr Leu Asn Thr His Thr Arg Ile His Ala Gly
                325                 330                 335     
Tyr Lys Pro Phe Val Cys Glu Phe Cys Gly Lys Gly Phe His Gln Lys
            340                 345                 350         
Gly Asn Tyr Lys Asn His Lys Leu Thr His Ser Gly Glu Lys Gln Phe
        355                 360                 365             
Lys Cys Asn Ile Cys Asn Lys Ala Phe His Gln Val Tyr Asn Leu Thr
    370                 375                 380                 
Phe His Met His Thr His Asn Asp Lys Lys Pro Phe Thr Cys Pro Thr
385                 390                 395                 400 
Cys Gly Lys Gly Phe Cys Arg Asn Phe Asp Leu Lys Lys His Val Arg
                405                 410                 415     
Lys Leu His Asp Ser Ser Leu Gly Leu Ala Arg Thr Pro Ala Gly Glu
            420                 425                 430         
Pro Gly Thr Glu Pro Pro Pro Pro Leu Pro Gln Gln Pro Pro Met Thr
        435                 440                 445             
Leu Pro Pro Leu Gln Pro Pro Leu Pro Thr Pro Gly Pro Leu Gln Pro
    450                 455                 460                 
Gly Leu His Gln Gly His Gln
465                 470     


<210> 8642
<211> 61
<212> PRT
<213> Homo sapiens

<400> 8642
Met Asp Pro Asn Cys Ser Cys Ser Thr Ser Ser Ser Cys Thr Cys Thr
 1               5                  10                  15      
Thr Ser Ser Lys Ser Arg Glu Cys Lys Cys Thr Ser Cys Lys Thr Ser
            20                  25                  30          
Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys
        35                  40                  45              
Val Cys Lys Gly Thr Ser Asp Lys Cys Ser Cys Cys Ser
    50                  55                  60      


<210> 8643
<211> 61
<212> PRT
<213> Homo sapiens

<400> 8643
Met Asp Pro Asn Cys Ser Cys Ser Thr Ile Gly Ser Cys Ala Cys Ala
 1               5                  10                  15      
Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser
            20                  25                  30          
Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys
        35                  40                  45              
Ile Cys Lys Gly Thr Ser Asp Lys Cys Ser Cys Cys Ala
    50                  55                  60      


<210> 8644
<211> 61
<212> PRT
<213> Homo sapiens

<400> 8644
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr Cys Ala
 1               5                  10                  15      
Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser
            20                  25                  30          
Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys
        35                  40                  45              
Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala
    50                  55                  60      


<210> 8645
<211> 494
<212> PRT
<213> Homo sapiens

<400> 8645
Met Asp Leu Ser Asn Asn Thr Met Ser Leu Ser Val Arg Thr Pro Gly
 1               5                  10                  15      
Leu Ser Arg Arg Leu Ser Ser Gln Ser Val Ile Gly Arg Pro Arg Gly
            20                  25                  30          
Met Ser Ala Ser Ser Val Gly Ser Gly Tyr Gly Gly Ser Ala Phe Gly
        35                  40                  45              
Phe Gly Ala Ser Cys Gly Gly Gly Phe Ser Ala Ala Ser Met Phe Gly
    50                  55                  60                  
Ser Ser Ser Gly Phe Gly Gly Gly Ser Gly Ser Ser Met Ala Gly Gly
65                  70                  75                  80  
Leu Gly Ala Gly Tyr Gly Arg Ala Leu Gly Gly Gly Ser Phe Gly Gly
                85                  90                  95      
Leu Gly Met Gly Phe Gly Gly Ser Pro Gly Gly Gly Ser Leu Gly Ile
            100                 105                 110         
Leu Ser Gly Asn Asp Gly Gly Leu Leu Ser Gly Ser Glu Lys Glu Thr
        115                 120                 125             
Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg
    130                 135                 140                 
Ala Leu Glu Glu Ala Asn Thr Glu Leu Glu Asn Lys Ile Arg Glu Trp
145                 150                 155                 160 
Tyr Glu Thr Arg Gly Thr Gly Thr Ala Asp Ala Ser Gln Ser Asp Tyr
                165                 170                 175     
Ser Lys Tyr Tyr Pro Leu Ile Glu Asp Leu Arg Asn Lys Ile Ile Ser
            180                 185                 190         
Ala Ser Ile Gly Asn Ala Gln Leu Leu Leu Gln Ile Asp Asn Ala Arg
        195                 200                 205             
Leu Ala Ala Glu Asp Phe Arg Met Lys Tyr Glu Asn Glu Leu Ala Leu
    210                 215                 220                 
Arg Gln Gly Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp
225                 230                 235                 240 
Glu Leu Thr Leu Thr Arg Thr Asp Leu Glu Met Gln Ile Glu Ser Leu
                245                 250                 255     
Asn Glu Glu Leu Ala Tyr Met Lys Lys Asn His Glu Asp Glu Leu Gln
            260                 265                 270         
Ser Phe Arg Val Gly Gly Pro Gly Glu Val Ser Val Glu Met Asp Ala
        275                 280                 285             
Ala Pro Gly Val Asp Leu Thr Arg Leu Leu Asn Asp Met Arg Ala Gln
    290                 295                 300                 
Tyr Glu Thr Ile Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe
305                 310                 315                 320 
Ile Glu Lys Ser Gly Glu Leu Arg Lys Glu Ile Ser Thr Asn Thr Glu
                325                 330                 335     
Gln Leu Gln Ser Ser Lys Ser Glu Val Thr Asp Leu Arg Arg Ala Phe
            340                 345                 350         
Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala Met Lys Lys Ser
        355                 360                 365             
Leu Glu Asp Ser Leu Ala Glu Ala Glu Gly Asp Tyr Cys Ala Gln Leu
    370                 375                 380                 
Ser Gln Val Gln Gln Leu Ile Ser Asn Leu Glu Ala Gln Leu Leu Gln
385                 390                 395                 400 
Val Arg Ala Asp Ala Glu Arg Gln Asn Val Asp His Gln Arg Leu Leu
                405                 410                 415     
Asn Val Lys Ala Arg Leu Glu Leu Glu Ile Glu Thr Tyr Arg Arg Leu
            420                 425                 430         
Leu Asp Gly Glu Ala Gln Gly Asp Gly Leu Glu Glu Ser Leu Phe Val
        435                 440                 445             
Thr Asp Ser Lys Ser Gln Ala Gln Ser Thr Asp Ser Ser Lys Asp Pro
    450                 455                 460                 
Thr Lys Thr Arg Lys Ile Lys Thr Val Val Gln Glu Met Val Asn Gly
465                 470                 475                 480 
Glu Val Val Ser Ser Gln Val Gln Glu Ile Glu Glu Leu Met
                485                 490                 


<210> 8646
<211> 374
<212> PRT
<213> Homo sapiens

<400> 8646
Met Asp Asp Leu Cys Glu Ala Asn Gly Thr Phe Ala Ile Ser Leu Phe
 1               5                  10                  15      
Lys Ile Leu Gly Glu Glu Asp Asn Ser Arg Asn Val Phe Phe Ser Pro
            20                  25                  30          
Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly
        35                  40                  45              
Ser Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Leu Tyr Lys Asp Gly
    50                  55                  60                  
Asp Ile His Arg Gly Phe Gln Ser Leu Leu Ser Glu Val Asn Arg Thr
65                  70                  75                  80  
Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys
                85                  90                  95      
Thr Cys Asp Phe Leu Pro Asp Phe Lys Glu Tyr Cys Gln Lys Phe Tyr
            100                 105                 110         
Gln Ala Glu Leu Glu Glu Leu Ser Phe Ala Glu Asp Thr Glu Glu Cys
        115                 120                 125             
Arg Lys His Ile Asn Asp Trp Val Ala Glu Lys Thr Glu Gly Lys Ile
    130                 135                 140                 
Ser Glu Val Leu Asp Ala Gly Thr Val Asp Pro Leu Thr Lys Leu Val
145                 150                 155                 160 
Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Gln Phe Asp
                165                 170                 175     
Arg Lys Tyr Thr Arg Gly Met Leu Phe Lys Thr Asn Glu Glu Lys Lys
            180                 185                 190         
Thr Val Gln Met Met Phe Lys Glu Ala Lys Phe Lys Met Gly Tyr Ala
        195                 200                 205             
Asp Glu Val His Thr Gln Val Leu Glu Leu Pro Tyr Val Glu Glu Glu
    210                 215                 220                 
Leu Ser Met Val Ile Leu Leu Pro Asp Asp Asn Thr Asp Leu Ala Val
225                 230                 235                 240 
Val Glu Lys Ala Leu Thr Tyr Glu Lys Phe Lys Ala Trp Thr Asn Ser
                245                 250                 255     
Glu Lys Leu Thr Lys Ser Lys Val Gln Val Phe Leu Pro Arg Leu Lys
            260                 265                 270         
Leu Glu Glu Ser Tyr Asp Leu Glu Pro Phe Leu Arg Arg Leu Gly Met
        275                 280                 285             
Ile Asp Ala Phe Asp Glu Ala Lys Ala Asp Phe Ser Gly Met Ser Thr
    290                 295                 300                 
Glu Lys Asn Val Pro Leu Ser Lys Val Ala His Lys Cys Phe Val Glu
305                 310                 315                 320 
Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Val Val Arg
                325                 330                 335     
Asn Ser Arg Cys Ser Arg Met Glu Pro Arg Phe Cys Ala Asp His Pro
            340                 345                 350         
Phe Leu Phe Phe Ile Arg Arg His Lys Thr Asn Cys Ile Leu Phe Cys
        355                 360                 365             
Gly Arg Phe Ser Ser Pro
    370                 


<210> 8647
<211> 365
<212> PRT
<213> Homo sapiens

<400> 8647
Met Asp Asp Leu Cys Glu Ala Asn Gly Thr Phe Ala Ile Ser Leu Phe
 1               5                  10                  15      
Lys Ile Leu Gly Glu Glu Asp Asn Ser Arg Asn Val Phe Phe Ser Pro
            20                  25                  30          
Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly
        35                  40                  45              
Ser Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Leu Tyr Lys Asp Gly
    50                  55                  60                  
Asp Ile His Arg Gly Phe Gln Ser Leu Leu Ser Glu Val Asn Arg Thr
65                  70                  75                  80  
Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys
                85                  90                  95      
Thr Cys Asp Phe Leu Pro Asp Phe Lys Glu Tyr Cys Gln Lys Phe Tyr
            100                 105                 110         
Gln Ala Glu Leu Glu Glu Leu Ser Phe Ala Glu Asp Thr Glu Glu Cys
        115                 120                 125             
Arg Lys His Ile Asn Asp Trp Val Ala Glu Lys Thr Glu Gly Lys Ile
    130                 135                 140                 
Ser Glu Val Leu Asp Ala Gly Thr Val Asp Pro Leu Thr Lys Leu Val
145                 150                 155                 160 
Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Gln Phe Asp
                165                 170                 175     
Arg Lys Tyr Thr Arg Gly Met Leu Phe Lys Thr Asn Glu Lys Ala Lys
            180                 185                 190         
Ala Ile Lys Pro Ile Leu Gln Gln Gly Asn Phe Pro Glu Phe Gly Pro
        195                 200                 205             
Tyr Ile Phe Ser Asn Gln Ile Leu Gln Pro Lys Gly Leu Asn Ile Tyr
    210                 215                 220                 
Leu Asn Phe Asp Lys Glu Phe Leu Val Glu Lys Ala Leu Thr Tyr Glu
225                 230                 235                 240 
Lys Phe Lys Ala Trp Thr Asn Ser Glu Lys Leu Thr Lys Ser Lys Val
                245                 250                 255     
Gln Val Phe Leu Pro Arg Leu Lys Leu Glu Glu Ser Tyr Asp Leu Glu
            260                 265                 270         
Pro Phe Leu Arg Arg Leu Gly Met Ile Asp Ala Phe Asp Glu Ala Lys
        275                 280                 285             
Ala Asp Phe Ser Gly Met Ser Thr Glu Lys Asn Val Pro Leu Ser Lys
    290                 295                 300                 
Val Ala His Lys Cys Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala
305                 310                 315                 320 
Ala Ala Ala Thr Ala Val Val Arg Asn Ser Arg Cys Ser Arg Met Glu
                325                 330                 335     
Pro Arg Phe Cys Ala Asp His Pro Phe Leu Phe Phe Ile Arg His His
            340                 345                 350         
Lys Thr Asn Cys Ile Leu Phe Cys Gly Arg Phe Ser Ser
        355                 360                 365 


<210> 8648
<211> 374
<212> PRT
<213> Homo sapiens

<400> 8648
Met Asp Asp Leu Cys Glu Ala Asn Gly Thr Phe Ala Ile Ser Leu Phe
 1               5                  10                  15      
Lys Ile Leu Gly Glu Glu Asp Asn Ser Arg Asn Val Phe Phe Ser Pro
            20                  25                  30          
Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly
        35                  40                  45              
Ser Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Leu Tyr Lys Asp Gly
    50                  55                  60                  
Asp Ile His Arg Gly Phe Gln Ser Leu Leu Ser Glu Val Asn Arg Thr
65                  70                  75                  80  
Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys
                85                  90                  95      
Thr Cys Asp Phe Leu Pro Asp Phe Lys Glu Tyr Cys Gln Lys Phe Tyr
            100                 105                 110         
Gln Ala Glu Leu Glu Glu Leu Ser Phe Ala Glu Asp Thr Glu Glu Cys
        115                 120                 125             
Arg Lys His Ile Asn Asp Trp Val Ala Glu Lys Thr Glu Gly Lys Ile
    130                 135                 140                 
Ser Glu Val Leu Asp Ala Gly Thr Val Asp Pro Leu Thr Lys Leu Val
145                 150                 155                 160 
Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Gln Phe Asp
                165                 170                 175     
Arg Lys Tyr Thr Arg Gly Met Leu Phe Lys Thr Asn Glu Glu Lys Lys
            180                 185                 190         
Thr Val Gln Met Met Phe Lys Glu Ala Lys Phe Lys Met Gly Tyr Ala
        195                 200                 205             
Asp Glu Val His Thr Gln Val Leu Glu Leu Pro Tyr Val Glu Glu Glu
    210                 215                 220                 
Leu Ser Met Val Ile Leu Leu Pro Asp Asp Asn Thr Asp Leu Ala Val
225                 230                 235                 240 
Val Glu Lys Ala Leu Thr Tyr Glu Lys Phe Lys Ala Trp Thr Asn Ser
                245                 250                 255     
Glu Lys Leu Thr Lys Ser Lys Val Gln Val Phe Leu Pro Arg Leu Lys
            260                 265                 270         
Leu Glu Glu Ser Tyr Asp Leu Glu Pro Phe Leu Arg Arg Leu Gly Met
        275                 280                 285             
Ile Asp Ala Phe Asp Glu Ala Lys Ala Asp Phe Ser Gly Met Ser Ala
    290                 295                 300                 
Glu Lys Asn Val Pro Leu Ser Lys Val Ala His Lys Cys Phe Val Glu
305                 310                 315                 320 
Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Val Val Arg
                325                 330                 335     
Asn Ser Arg Cys Ser Arg Met Glu Pro Arg Phe Cys Ala Asp His Pro
            340                 345                 350         
Phe Leu Phe Phe Ile Arg His His Lys Thr Asn Cys Ile Leu Phe Cys
        355                 360                 365             
Gly Arg Phe Ser Ser Pro
    370                 


<210> 8649
<211> 375
<212> PRT
<213> Homo sapiens

<400> 8649
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met
 1               5                  10                  15      
Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro
            20                  25                  30          
Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly
        35                  40                  45              
Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile
    50                  55                  60                  
Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp
65                  70                  75                  80  
Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val
                85                  90                  95      
Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro
            100                 105                 110         
Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn
        115                 120                 125             
Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala
    130                 135                 140                 
Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr
145                 150                 155                 160 
His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu
                165                 170                 175     
Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile
            180                 185                 190         
Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile
        195                 200                 205             
Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu
    210                 215                 220                 
Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr
225                 230                 235                 240 
Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg
                245                 250                 255     
Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys
            260                 265                 270         
Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp
        275                 280                 285             
Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr
    290                 295                 300                 
Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu
305                 310                 315                 320 
Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys
                325                 330                 335     
Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe
            340                 345                 350         
Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser
        355                 360                 365             
Ile Val His Arg Lys Cys Phe
    370                 375 


<210> 8650
<211> 217
<212> PRT
<213> Homo sapiens

<400> 8650
Met Ala Tyr Pro Gly Tyr Gly Gly Gly Phe Gly Asn Phe Ser Ile Gln
 1               5                  10                  15      
Val Pro Gly Met Gln Met Gly Gln Pro Val Pro Glu Thr Gly Pro Ala
            20                  25                  30          
Ile Leu Leu Asp Gly Tyr Ser Gly Pro Ala Tyr Ser Asp Thr Tyr Ser
        35                  40                  45              
Ser Ala Gly Asp Ser Val Tyr Thr Tyr Phe Ser Ala Val Ala Gly Gln
    50                  55                  60                  
Asp Gly Glu Val Asp Ala Glu Glu Leu Gln Arg Cys Leu Thr Gln Ser
65                  70                  75                  80  
Gly Ile Asn Gly Thr Tyr Ser Pro Phe Ser Leu Glu Thr Cys Arg Ile
                85                  90                  95      
Met Ile Ala Met Leu Asp Arg Asp His Thr Gly Lys Met Gly Phe Asn
            100                 105                 110         
Ala Phe Lys Glu Leu Trp Ala Ala Leu Asn Ala Trp Lys Glu Asn Phe
        115                 120                 125             
Met Thr Val Asp Gln Asp Gly Ser Gly Thr Val Glu His His Glu Leu
    130                 135                 140                 
Arg Gln Ala Ile Gly Leu Met Gly Tyr Arg Leu Ser Pro Gln Thr Leu
145                 150                 155                 160 
Thr Thr Ile Val Lys Arg Tyr Ser Lys Asn Gly Arg Ile Phe Phe Asp
                165                 170                 175     
Asp Tyr Val Ala Cys Cys Val Lys Leu Arg Ala Leu Thr Asp Phe Phe
            180                 185                 190         
Arg Lys Arg Asp His Leu Gln Gln Gly Ser Ala Asn Phe Ile Tyr Asp
        195                 200                 205             
Asp Phe Leu Gln Gly Thr Met Ala Ile
    210                 215         


<210> 8651
<211> 293
<212> PRT
<213> Homo sapiens

<400> 8651
Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser
 1               5                  10                  15      
Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp
            20                  25                  30          
Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val
        35                  40                  45              
His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg
    50                  55                  60                  
Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Val
65                  70                  75                  80  
Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly
                85                  90                  95      
Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp
            100                 105                 110         
Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala
        115                 120                 125             
Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Val Val Pro Ser Lys
    130                 135                 140                 
Arg Gln Arg Leu Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe
145                 150                 155                 160 
Asn Ser Lys Ser Gly Lys Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys
                165                 170                 175     
Gly Asp Asp Leu Gln Ala Ile Lys Gln Glu Leu Thr Gln Ile Lys Gln
            180                 185                 190         
Lys Val Asp Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln
        195                 200                 205             
Ser Lys Gln Glu Val Glu Val Lys Asn Ala Lys Ser Glu Glu Glu Gln
    210                 215                 220                 
Ser Ser Ser Ser Met Lys Lys Asp Glu Thr His Val Lys Met Glu Ser
225                 230                 235                 240 
Glu Gly Gly Ala Glu Asp Ser Ala Glu Glu Gly Asp Pro Leu Asp Asp
                245                 250                 255     
Asp Val Asn Glu Asp Gln Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp
            260                 265                 270         
Asp Glu Lys Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Thr Asn
        275                 280                 285             
Gly Gln Asp Asp Ser
    290             


<210> 8652
<211> 348
<212> PRT
<213> Homo sapiens

<400> 8652
Met Ala His Ser Gln Asn Ser Leu Glu Leu Pro Ile Asn Ile Asn Ala
 1               5                  10                  15      
Thr Gln Ile Thr Thr Ala Tyr Gly His Arg Ala Leu Pro Lys Leu Lys
            20                  25                  30          
Glu Glu Leu Gln Ser Glu Asp Leu Gln Thr Arg Gln Lys Ala Leu Met
        35                  40                  45              
Ala Leu Cys Asp Leu Met His Asp Pro Glu Cys Ile Tyr Lys Ala Met
    50                  55                  60                  
Asn Ile Gly Cys Met Glu Asn Leu Lys Ala Leu Leu Lys Asp Ser Asn
65                  70                  75                  80  
Ser Met Val Arg Ile Lys Thr Thr Glu Val Leu His Ile Thr Ala Ser
                85                  90                  95      
His Ser Val Gly Arg Tyr Ala Phe Leu Glu His Asp Ile Val Leu Ala
            100                 105                 110         
Leu Ser Phe Leu Leu Asn Asp Pro Ser Pro Val Cys Arg Gly Asn Leu
        115                 120                 125             
Tyr Lys Ala Tyr Met Gln Leu Val Gln Val Pro Arg Gly Ala Gln Glu
    130                 135                 140                 
Ile Ile Ser Lys Gly Leu Ile Ser Ser Leu Val Trp Lys Leu Gln Val
145                 150                 155                 160 
Glu Val Glu Glu Glu Glu Phe Gln Glu Phe Ile Leu Asp Thr Leu Val
                165                 170                 175     
Leu Cys Leu Gln Glu Asp Ala Thr Glu Ala Leu Gly Ser Asn Val Val
            180                 185                 190         
Leu Val Leu Lys Gln Lys Leu Leu Ser Ala Asn Gln Asn Ile Arg Ser
        195                 200                 205             
Lys Ala Ala Arg Ala Leu Leu Asn Val Ser Ile Ser Arg Glu Gly Lys
    210                 215                 220                 
Lys Gln Val Cys His Phe Asp Val Ile Pro Ile Leu Val His Leu Leu
225                 230                 235                 240 
Lys Asp Pro Val Glu His Val Lys Ser Asn Ala Ala Gly Ala Leu Met
                245                 250                 255     
Phe Ala Thr Val Ile Thr Glu Gly Lys Tyr Ala Ala Leu Glu Ala Gln
            260                 265                 270         
Ala Ile Gly Leu Leu Leu Glu Leu Leu His Ser Pro Met Thr Ile Ala
        275                 280                 285             
Arg Leu Asn Ala Thr Lys Ala Leu Thr Met Leu Ala Glu Ala Pro Glu
    290                 295                 300                 
Gly Arg Lys Ala Leu Gln Thr His Val Pro Thr Phe Arg Ala Met Glu
305                 310                 315                 320 
Val Glu Thr Tyr Glu Lys Pro Gln Val Ala Glu Ala Leu Gln Arg Ala
                325                 330                 335     
Ala Arg Ile Ala Ile Ser Val Ile Glu Phe Lys Pro
            340                 345             


<210> 8653
<211> 1074
<212> PRT
<213> Homo sapiens

<400> 8653
Met Lys Gly Thr Cys Val Ile Ala Trp Leu Phe Ser Ser Leu Gly Leu
 1               5                  10                  15      
Trp Arg Leu Ala His Pro Glu Ala Gln Gly Thr Thr Gln Cys Gln Arg
            20                  25                  30          
Thr Glu His Pro Val Ile Ser Tyr Lys Glu Ile Gly Pro Trp Leu Arg
        35                  40                  45              
Glu Phe Arg Ala Lys Asn Ala Ala Asp Phe Ser Gln Leu Thr Phe Asp
    50                  55                  60                  
Pro Gly Gln Lys Glu Leu Val Val Gly Ala Arg Asn Tyr Leu Phe Arg
65                  70                  75                  80  
Leu Gln Leu Glu Asp Leu Ser Leu Ile Gln Ala Val Glu Trp Glu Cys
                85                  90                  95      
Asp Glu Ala Thr Lys Lys Ala Cys Tyr Ser Lys Gly Lys Ser Lys Glu
            100                 105                 110         
Glu Cys Gln Asn Tyr Ile Arg Val Leu Leu Val Gly Gly Asp Arg Leu
        115                 120                 125             
Phe Thr Cys Gly Thr Asn Ala Phe Thr Pro Val Cys Thr Asn Arg Ser
    130                 135                 140                 
Leu Ser Asn Leu Ala Glu Ile His Asp Gln Ile Ser Gly Met Ala Arg
145                 150                 155                 160 
Cys Pro Tyr Ser Pro Gln His Asn Ser Thr Ala Leu Leu Thr Ala Gly
                165                 170                 175     
Gly Glu Leu Tyr Ala Ala Thr Ala Met Asp Phe Pro Gly Arg Asp Pro
            180                 185                 190         
Ala Ile Tyr Arg Ser Leu Gly Ile Leu Pro Pro Leu Arg Thr Ala Gln
        195                 200                 205             
Tyr Asn Ser Lys Trp Leu Asn Glu Pro Asn Phe Val Ser Ser Tyr Asp
    210                 215                 220                 
Ile Gly Asn Phe Thr Tyr Phe Phe Phe Arg Glu Asn Ala Val Glu His
225                 230                 235                 240 
Asp Cys Gly Lys Thr Val Phe Ser Arg Ala Ala Arg Val Cys Lys Asn
                245                 250                 255     
Asp Ile Gly Gly Arg Phe Leu Leu Glu Asp Thr Trp Thr Thr Phe Met
            260                 265                 270         
Lys Ala Arg Leu Asn Cys Ser Arg Pro Gly Glu Val Pro Phe Tyr Tyr
        275                 280                 285             
Asn Glu Leu Gln Ser Thr Phe Phe Leu Pro Glu Leu Asp Leu Ile Tyr
    290                 295                 300                 
Gly Ile Phe Thr Thr Asn Val Asn Ser Ile Ala Ala Ser Ala Val Cys
305                 310                 315                 320 
Val Phe Asn Leu Ser Ala Ile Ala Gln Ala Phe Ser Gly Pro Phe Lys
                325                 330                 335     
Tyr Gln Glu Asn Ser Arg Ser Ala Trp Leu Pro Tyr Pro Asn Pro Asn
            340                 345                 350         
Pro His Phe Gln Cys Gly Thr Val Asp Gln Gly Leu Tyr Val Asn Leu
        355                 360                 365             
Thr Glu Arg Asn Leu Gln Asp Ala Gln Lys Phe Ile Leu Val His Glu
    370                 375                 380                 
Val Val Gln Pro Val Thr Thr Val Pro Ser Phe Met Glu Asp Asn Ser
385                 390                 395                 400 
Arg Phe Ser His Val Ala Val Asp Val Val Gln Gly Arg Glu Ala Leu
                405                 410                 415     
Val His Ile Ile Tyr Leu Ala Thr Asp Tyr Gly Thr Ile Lys Lys Val
            420                 425                 430         
Arg Val Pro Leu Asn Gln Thr Ser Ser Ser Cys Leu Leu Glu Glu Ile
        435                 440                 445             
Glu Leu Phe Pro Glu Arg Arg Arg Glu Pro Ile Arg Ser Leu Gln Ile
    450                 455                 460                 
Leu His Ser Gln Ser Val Leu Phe Val Gly Leu Arg Glu His Val Val
465                 470                 475                 480 
Lys Ile Pro Leu Lys Arg Cys Gln Phe Tyr Arg Thr Arg Ser Thr Cys
                485                 490                 495     
Ile Gly Ala Gln Asp Pro Tyr Cys Gly Trp Asp Val Val Met Lys Lys
            500                 505                 510         
Cys Thr Ser Leu Glu Glu Ser Leu Ser Met Thr Gln Trp Glu Gln Ser
        515                 520                 525             
Ile Ser Ala Cys Pro Thr Arg Asn Leu Thr Val Asp Gly His Phe Gly
    530                 535                 540                 
Val Trp Ser Pro Trp Thr Pro Cys Thr His Thr Asp Gly Ser Ala Val
545                 550                 555                 560 
Gly Ser Cys Leu Cys Arg Thr Arg Ser Cys Asp Ser Pro Ala Pro Gln
                565                 570                 575     
Cys Gly Gly Trp Gln Cys Glu Gly Pro Gly Met Glu Ile Ala Asn Cys
            580                 585                 590         
Ser Arg Asn Gly Gly Trp Thr Pro Trp Thr Ser Trp Ser Pro Cys Ser
        595                 600                 605             
Thr Thr Cys Gly Ile Gly Phe Gln Val Arg Gln Arg Ser Cys Ser Asn
    610                 615                 620                 
Pro Thr Pro Arg His Gly Gly Arg Val Cys Val Gly Gln Asn Arg Glu
625                 630                 635                 640 
Glu Arg Tyr Cys Asn Glu His Leu Leu Cys Pro Pro His Met Phe Trp
                645                 650                 655     
Thr Gly Trp Gly Pro Trp Glu Arg Cys Thr Ala Gln Cys Gly Gly Gly
            660                 665                 670         
Ile Gln Ala Arg Arg Arg Ile Cys Glu Asn Gly Pro Asp Cys Ala Gly
        675                 680                 685             
Cys Asn Val Glu Tyr Gln Ser Cys Asn Thr Asn Pro Cys Pro Glu Leu
    690                 695                 700                 
Lys Lys Thr Thr Pro Trp Thr Pro Trp Thr Pro Val Asn Ile Ser Asp
705                 710                 715                 720 
Asn Gly Asp His Tyr Glu Gln Arg Phe Arg Tyr Thr Cys Lys Ala Arg
                725                 730                 735     
Leu Ala Asp Pro Asn Leu Leu Glu Val Gly Arg Gln Arg Ile Glu Met
            740                 745                 750         
Arg Tyr Cys Ser Ser Asp Gly Thr Ser Gly Cys Ser Thr Asp Gly Leu
        755                 760                 765             
Ser Gly Asp Phe Leu Arg Ala Gly Arg Tyr Ser Ala His Thr Val Asn
    770                 775                 780                 
Gly Ala Trp Ser Ala Trp Thr Ser Trp Ser Gln Cys Ser Arg Asp Cys
785                 790                 795                 800 
Ser Arg Gly Ile Arg Asn Arg Lys Arg Val Cys Asn Asn Pro Glu Pro
                805                 810                 815     
Lys Tyr Gly Gly Met Pro Cys Leu Gly Pro Ser Leu Glu Tyr Gln Glu
            820                 825                 830         
Cys Asn Thr Leu Pro Cys Pro Val Asp Gly Val Trp Ser Cys Trp Ser
        835                 840                 845             
Pro Trp Thr Lys Cys Ser Ala Thr Cys Gly Gly Gly His Tyr Met Arg
    850                 855                 860                 
Thr Arg Ser Cys Ser Asn Pro Ala Pro Ala Tyr Gly Gly Asp Ile Cys
865                 870                 875                 880 
Leu Gly Leu His Thr Glu Glu Ala Leu Cys Asn Thr Gln Pro Cys Pro
                885                 890                 895     
Glu Ser Trp Ser Glu Trp Ser Asp Trp Ser Glu Cys Glu Ala Ser Gly
            900                 905                 910         
Val Gln Val Arg Ala Arg Gln Cys Ile Leu Leu Phe Pro Met Gly Ser
        915                 920                 925             
Gln Cys Ser Gly Asn Thr Thr Glu Ser Arg Pro Cys Val Phe Asp Ser
    930                 935                 940                 
Asn Phe Ile Pro Glu Val Ser Val Ala Arg Ser Ser Ser Val Glu Glu
945                 950                 955                 960 
Lys Arg Cys Gly Glu Phe Asn Met Phe His Met Ile Ala Val Gly Leu
                965                 970                 975     
Ser Ser Ser Ile Leu Gly Cys Leu Leu Thr Leu Leu Val Tyr Thr Tyr
            980                 985                 990         
Cys Gln Arg Tyr Gln Gln Gln Ser His Asp Ala Thr Val Ile His Pro
        995                 1000                1005            
Val Ser Pro Ala Pro Leu Asn Thr Ser Ile Thr Asn His Ile Asn Lys
    1010                1015                1020                
Leu Asp Lys Tyr Asp Ser Val Glu Ala Ile Lys Ala Phe Asn Lys Asn
1025                1030                1035                1040
Asn Leu Ile Leu Glu Glu Arg Asn Lys Tyr Phe Asn Pro His Leu Thr
                1045                1050                1055    
Gly Lys Thr Tyr Ser Asn Ala Tyr Phe Thr Asp Leu Asn Asn Tyr Asp
            1060                1065                1070        
Glu Tyr
        


<210> 8654
<211> 1158
<212> PRT
<213> Homo sapiens

<400> 8654
Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser Ser His Leu Arg
 1               5                  10                  15      
Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu Trp Pro Gly Arg
            20                  25                  30          
Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val Phe Gly Lys Glu
        35                  40                  45              
Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val Val Pro Gly Ser
    50                  55                  60                  
Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe Arg Gln Pro Leu
65                  70                  75                  80  
Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly Met Pro Gly Ala
                85                  90                  95      
Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Leu Ile Arg Thr
            100                 105                 110         
Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg Gly Gln Gln Glu
        115                 120                 125             
Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg Arg Glu Ala Val
    130                 135                 140                 
Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His Asn Glu Ala Phe
145                 150                 155                 160 
Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val Gly Asp Gln Leu
                165                 170                 175     
Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro Gly Ser Tyr Ser
            180                 185                 190         
Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val Arg Phe His Gly
        195                 200                 205             
Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met Asn Ile Val Asp
    210                 215                 220                 
Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Ile Ala Leu
225                 230                 235                 240 
Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu Ser Leu Ile Glu
                245                 250                 255     
Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys Arg Trp Ala His
            260                 265                 270         
Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His His Asp His Val
        275                 280                 285             
Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr
    290                 295                 300                 
Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser Cys Ala Leu Asn
305                 310                 315                 320 
His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala His Glu Thr Gly
                325                 330                 335     
His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Gly Cys Ala Asp
            340                 345                 350         
Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala Phe
        355                 360                 365             
His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu Leu Ser Arg Tyr
    370                 375                 380                 
Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp Pro Ala Trp
385                 390                 395                 400 
Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu Gln
                405                 410                 415     
Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys Leu Ala Phe Arg
            420                 425                 430         
Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro
        435                 440                 445             
Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu Cys
    450                 455                 460                 
Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile Trp Lys Ser Pro
465                 470                 475                 480 
Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser Trp Thr Lys Phe
                485                 490                 495     
Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg Ser Arg Ser Arg
            500                 505                 510         
Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg Pro Cys Leu Gly
        515                 520                 525             
Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu Cys Pro Gly Thr
    530                 535                 540                 
Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg Asn Ser Tyr Tyr
545                 550                 555                 560 
Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr Glu Pro Asp Asp
                565                 570                 575     
Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala Asp Thr Gly Asp
            580                 585                 590         
Val Val Phe Met Asn Gln Val Val His Asp Gly Thr Arg Cys Ser Tyr
        595                 600                 605             
Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys Val Pro Val Gly
    610                 615                 620                 
Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp Lys Cys Gly Val
625                 630                 635                 640 
Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Leu Gly
                645                 650                 655     
Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val Gln Ile Pro Ala
            660                 665                 670         
Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys Ser Pro His Arg
        675                 680                 685             
Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile Leu Asn Pro Lys
    690                 695                 700                 
Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met Gly Leu Glu Trp
705                 710                 715                 720 
Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys Thr Ser Gly Pro
                725                 730                 735     
Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro Thr Glu Gly Gly
            740                 745                 750         
Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His Glu Asp Leu Leu
        755                 760                 765             
Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu Met Asp Thr Tyr
    770                 775                 780                 
Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys Ala Cys Gly Gly
785                 790                 795                 800 
Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg Arg Asp His His
                805                 810                 815     
Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg Pro Lys Pro Ile
            820                 825                 830         
Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro Val Trp Val Thr
        835                 840                 845             
Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys Leu Gly Val Gln
    850                 855                 860                 
Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn Gly Thr His Lys
865                 870                 875                 880 
Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro Glu Ala Arg Arg
                885                 890                 895     
Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg Leu Gly Ala Trp
            900                 905                 910         
Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln Gln Arg Gln Val
        915                 920                 925             
Val Cys Arg Thr Asn Ala Asn Ser Leu Gly His Cys Glu Gly Asp Arg
    930                 935                 940                 
Pro Asp Thr Val Gln Val Cys Ser Leu Pro Ala Cys Gly Gly Asn His
945                 950                 955                 960 
Gln Asn Ser Thr Val Arg Ala Asp Val Trp Glu Leu Gly Thr Pro Glu
                965                 970                 975     
Gly Gln Trp Val Pro Gln Ser Glu Pro Leu His Pro Ile Asn Lys Ile
            980                 985                 990         
Ser Ser Thr Glu Pro Cys Thr Gly Asp Arg Ser Val Phe Cys Gln Met
        995                 1000                1005            
Glu Val Leu Asp Arg Tyr Cys Ser Ile Pro Gly Tyr His Arg Leu Cys
    1010                1015                1020                
Cys Val Ser Cys Ile Lys Lys Ala Ser Gly Pro Asn Pro Gly Pro Asp
1025                1030                1035                1040
Pro Gly Pro Thr Ser Leu Pro Pro Phe Ser Thr Pro Gly Ser Pro Leu
                1045                1050                1055    
Pro Gly Pro Gln Asp Pro Ala Asp Ala Ala Glu Pro Pro Gly Lys Pro
            1060                1065                1070        
Thr Gly Ser Glu Asp His Gln His Gly Arg Ala Thr Gln Leu Pro Gly
        1075                1080                1085            
Ala Leu Asp Thr Ser Ser Pro Gly Thr Gln His Pro Phe Ala Pro Glu
    1090                1095                1100                
Thr Pro Ile Pro Gly Ala Ser Trp Ser Ile Ser Pro Thr Thr Pro Gly
1105                1110                1115                1120
Gly Leu Pro Trp Gly Trp Thr Gln Thr Pro Thr Pro Val Pro Glu Asp
                1125                1130                1135    
Lys Gly Gln Pro Gly Glu Asp Leu Arg His Pro Gly Thr Ser Leu Pro
            1140                1145                1150        
Ala Ala Ser Pro Val Thr
        1155            


<210> 8655
<211> 1223
<212> PRT
<213> Homo sapiens

<400> 8655
Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys
 1               5                  10                  15      
Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser
            20                  25                  30          
Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe
        35                  40                  45              
Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser
    50                  55                  60                  
Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser
65                  70                  75                  80  
Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu
                85                  90                  95      
Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val
            100                 105                 110         
Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val
        115                 120                 125             
Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe
    130                 135                 140                 
Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly
145                 150                 155                 160 
Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly
                165                 170                 175     
Leu Ile Arg Thr Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg
            180                 185                 190         
Gly Gln Gln Glu Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg
        195                 200                 205             
Arg Glu Ala Val Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His
    210                 215                 220                 
Asn Glu Ala Phe Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val
225                 230                 235                 240 
Gly Asp Gln Leu Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro
                245                 250                 255     
Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val
            260                 265                 270         
Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met
        275                 280                 285             
Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile
    290                 295                 300                 
Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu
305                 310                 315                 320 
Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys
                325                 330                 335     
Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His
            340                 345                 350         
His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly
        355                 360                 365             
Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser Cys Ala Leu
    370                 375                 380                 
Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala His Glu Thr
385                 390                 395                 400 
Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Gly Cys Ala
                405                 410                 415     
Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala
            420                 425                 430         
Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu Leu Ser Arg
        435                 440                 445             
Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp Pro Ala
    450                 455                 460                 
Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu
465                 470                 475                 480 
Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys Leu Ala Phe
                485                 490                 495     
Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn
            500                 505                 510         
Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu
        515                 520                 525             
Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile Trp Lys Ser
    530                 535                 540                 
Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser Trp Thr Lys
545                 550                 555                 560 
Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg Ser Arg Ser
                565                 570                 575     
Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg Pro Cys Leu
            580                 585                 590         
Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu Cys Pro Gly
        595                 600                 605             
Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg Asn Ser Tyr
    610                 615                 620                 
Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr Glu Pro Asp
625                 630                 635                 640 
Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala Asp Thr Gly
                645                 650                 655     
Asp Val Val Phe Met Asn Gln Val Val His Asp Gly Thr Arg Cys Ser
            660                 665                 670         
Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys Val Pro Val
        675                 680                 685             
Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp Lys Cys Gly
    690                 695                 700                 
Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Leu
705                 710                 715                 720 
Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val Gln Ile Pro
                725                 730                 735     
Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys Ser Pro His
            740                 745                 750         
Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile Leu Asn Pro
        755                 760                 765             
Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met Gly Leu Glu
    770                 775                 780                 
Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys Thr Ser Gly
785                 790                 795                 800 
Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro Thr Glu Gly
                805                 810                 815     
Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His Glu Asp Leu
            820                 825                 830         
Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu Met Asp Thr
        835                 840                 845             
Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys Ala Cys Gly
    850                 855                 860                 
Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg Arg Asp His
865                 870                 875                 880 
His Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg Pro Lys Pro
                885                 890                 895     
Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro Val Trp Val
            900                 905                 910         
Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys Leu Gly Val
        915                 920                 925             
Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn Gly Thr His
    930                 935                 940                 
Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro Glu Ala Arg
945                 950                 955                 960 
Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg Leu Gly Ala
                965                 970                 975     
Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln Gln Arg Gln
            980                 985                 990         
Val Val Cys Arg Thr Asn Ala Asn Ser Leu Gly His Cys Glu Gly Asp
        995                 1000                1005            
Arg Pro Asp Thr Val Gln Val Cys Ser Leu Pro Ala Cys Gly Gly Asn
    1010                1015                1020                
His Gln Asn Ser Thr Val Arg Ala Asp Val Trp Glu Leu Gly Thr Pro
1025                1030                1035                1040
Glu Gly Gln Trp Val Pro Gln Ser Glu Pro Leu His Pro Ile Asn Lys
                1045                1050                1055    
Ile Ser Ser Thr Glu Pro Cys Thr Gly Asp Arg Ser Val Phe Cys Gln
            1060                1065                1070        
Met Glu Val Leu Asp Arg Tyr Cys Ser Ile Pro Gly Tyr His Arg Leu
        1075                1080                1085            
Cys Cys Val Ser Cys Ile Lys Lys Ala Ser Gly Pro Asn Pro Gly Pro
    1090                1095                1100                
Asp Pro Gly Pro Thr Ser Leu Pro Pro Phe Ser Thr Pro Gly Ser Pro
1105                1110                1115                1120
Leu Pro Gly Pro Gln Asp Pro Ala Asp Ala Ala Glu Pro Pro Gly Lys
                1125                1130                1135    
Pro Thr Gly Ser Glu Asp His Gln His Gly Arg Ala Thr Gln Leu Pro
            1140                1145                1150        
Gly Ala Leu Asp Thr Ser Ser Pro Gly Thr Gln His Pro Phe Ala Pro
        1155                1160                1165            
Glu Thr Pro Ile Pro Gly Ala Ser Trp Ser Ile Ser Pro Thr Thr Pro
    1170                1175                1180                
Gly Gly Leu Pro Trp Gly Trp Thr Gln Thr Pro Thr Pro Val Pro Glu
1185                1190                1195                1200
Asp Lys Gly Gln Pro Gly Glu Asp Leu Arg His Pro Gly Thr Ser Leu
                1205                1210                1215    
Pro Ala Ala Ser Pro Val Thr
            1220            


<210> 8656
<211> 1155
<212> PRT
<213> Homo sapiens

<400> 8656
Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser Ser His Leu Arg
 1               5                  10                  15      
Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu Trp Pro Gly Arg
            20                  25                  30          
Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val Phe Gly Lys Glu
        35                  40                  45              
Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val Val Pro Gly Ser
    50                  55                  60                  
Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe Arg Gln Pro Leu
65                  70                  75                  80  
Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly Met Pro Gly Ala
                85                  90                  95      
Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Leu Ile Arg Thr
            100                 105                 110         
Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg Gly Gln Gln Glu
        115                 120                 125             
Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg Arg Glu Ala Val
    130                 135                 140                 
Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His Asn Glu Ala Phe
145                 150                 155                 160 
Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val Gly Asp Gln Leu
                165                 170                 175     
Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro Gly Ser Tyr Ser
            180                 185                 190         
Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val Arg Phe His Gly
        195                 200                 205             
Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met Asn Ile Val Asp
    210                 215                 220                 
Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Ile Ala Leu
225                 230                 235                 240 
Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu Ser Leu Ile Glu
                245                 250                 255     
Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys Arg Trp Ala His
            260                 265                 270         
Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His His Asp His Val
        275                 280                 285             
Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly Tyr Ala Pro Val
    290                 295                 300                 
Thr Gly Met Cys His Pro Leu Arg Ser Cys Ala Leu Asn His Glu Asp
305                 310                 315                 320 
Gly Phe Ser Ser Ala Phe Val Ile Ala His Glu Thr Gly His Val Leu
                325                 330                 335     
Gly Met Glu His Asp Gly Gln Gly Asn Gly Cys Ala Asp Glu Thr Ser
            340                 345                 350         
Leu Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe
        355                 360                 365             
His Trp Ser Arg Cys Ser Lys Leu Glu Leu Ser Arg Tyr Leu Pro Ser
    370                 375                 380                 
Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp Pro Ala Trp Pro Gln Pro
385                 390                 395                 400 
Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu Gln Cys Arg Phe
                405                 410                 415     
Asp Phe Gly Ser Gly Tyr Gln Thr Cys Leu Ala Phe Arg Thr Phe Glu
            420                 425                 430         
Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys
        435                 440                 445             
Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu Cys Ala Pro Gly
    450                 455                 460                 
Lys Trp Cys Phe Lys Gly His Cys Ile Trp Lys Ser Pro Glu Gln Thr
465                 470                 475                 480 
Tyr Gly Gln Asp Gly Gly Trp Ser Ser Trp Thr Lys Phe Gly Ser Cys
                485                 490                 495     
Ser Arg Ser Cys Gly Gly Gly Val Arg Ser Arg Ser Arg Ser Cys Asn
            500                 505                 510         
Asn Pro Ser Pro Ala Tyr Gly Gly Arg Pro Cys Leu Gly Pro Met Phe
        515                 520                 525             
Glu Tyr Gln Val Cys Asn Ser Glu Glu Cys Pro Gly Thr Tyr Glu Asp
    530                 535                 540                 
Phe Arg Ala Gln Gln Cys Ala Lys Arg Asn Ser Tyr Tyr Val His Gln
545                 550                 555                 560 
Asn Ala Lys His Ser Trp Val Pro Tyr Glu Pro Asp Asp Asp Ala Gln
                565                 570                 575     
Lys Cys Glu Leu Ile Cys Gln Ser Ala Asp Thr Gly Asp Val Val Phe
            580                 585                 590         
Met Asn Gln Val Val His Asp Gly Thr Arg Cys Ser Tyr Arg Asp Pro
        595                 600                 605             
Tyr Ser Val Cys Ala Arg Gly Glu Cys Val Pro Val Gly Cys Asp Lys
    610                 615                 620                 
Glu Val Gly Ser Met Lys Ala Asp Asp Lys Cys Gly Val Cys Gly Gly
625                 630                 635                 640 
Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Leu Gly Lys Ala Ser
                645                 650                 655     
Lys Gln Ala Gly Ala Leu Lys Leu Val Gln Ile Pro Ala Gly Ala Arg
            660                 665                 670         
His Ile Gln Ile Glu Ala Leu Glu Lys Ser Pro His Arg Ile Val Val
        675                 680                 685             
Lys Asn Gln Val Thr Gly Ser Phe Ile Leu Asn Pro Lys Gly Lys Glu
    690                 695                 700                 
Ala Thr Ser Arg Thr Phe Thr Ala Met Gly Leu Glu Trp Glu Asp Ala
705                 710                 715                 720 
Val Glu Asp Ala Lys Glu Ser Leu Lys Thr Ser Gly Pro Leu Pro Glu
                725                 730                 735     
Ala Ile Ala Ile Leu Ala Leu Pro Pro Thr Glu Gly Gly Pro Arg Ser
            740                 745                 750         
Ser Leu Ala Tyr Lys Tyr Val Ile His Glu Asp Leu Leu Pro Leu Ile
        755                 760                 765             
Gly Ser Asn Asn Val Leu Leu Glu Glu Met Asp Thr Tyr Glu Trp Ala
    770                 775                 780                 
Leu Lys Ser Trp Ala Pro Cys Ser Lys Ala Cys Gly Gly Gly Ile Gln
785                 790                 795                 800 
Phe Thr Lys Tyr Gly Cys Arg Arg Arg Arg Asp His His Met Val Gln
                805                 810                 815     
Arg His Leu Cys Asp His Lys Lys Arg Pro Lys Pro Ile Arg Arg Arg
            820                 825                 830         
Cys Asn Gln His Pro Cys Ser Gln Pro Val Trp Val Thr Glu Glu Trp
        835                 840                 845             
Gly Ala Cys Ser Arg Ser Cys Gly Lys Leu Gly Val Gln Thr Arg Gly
    850                 855                 860                 
Ile Gln Cys Leu Leu Pro Leu Ser Asn Gly Thr His Lys Val Met Pro
865                 870                 875                 880 
Ala Lys Ala Cys Ala Gly Asp Arg Pro Glu Ala Arg Arg Pro Cys Leu
                885                 890                 895     
Arg Val Pro Cys Pro Ala Gln Trp Arg Leu Gly Ala Trp Ser Gln Cys
            900                 905                 910         
Ser Ala Thr Cys Gly Glu Gly Ile Gln Gln Arg Gln Val Val Cys Arg
        915                 920                 925             
Thr Asn Ala Asn Ser Leu Gly His Cys Glu Gly Asp Arg Pro Asp Thr
    930                 935                 940                 
Val Gln Val Cys Ser Leu Pro Ala Cys Gly Gly Asn His Gln Asn Ser
945                 950                 955                 960 
Thr Val Arg Ala Asp Val Trp Glu Leu Gly Thr Pro Glu Gly Gln Trp
                965                 970                 975     
Val Pro Gln Ser Glu Pro Leu His Pro Ile Asn Lys Ile Ser Ser Thr
            980                 985                 990         
Glu Pro Cys Thr Gly Asp Arg Ser Val Phe Cys Gln Met Glu Val Leu
        995                 1000                1005            
Asp Arg Tyr Cys Ser Ile Pro Gly Tyr His Arg Leu Cys Cys Val Ser
    1010                1015                1020                
Cys Ile Lys Lys Ala Ser Gly Pro Asn Pro Gly Pro Asp Pro Gly Pro
1025                1030                1035                1040
Thr Ser Leu Pro Pro Phe Ser Thr Pro Gly Ser Pro Leu Pro Gly Pro
                1045                1050                1055    
Gln Asp Pro Ala Asp Ala Ala Glu Pro Pro Gly Lys Pro Thr Gly Ser
            1060                1065                1070        
Glu Asp His Gln His Gly Arg Ala Thr Gln Leu Pro Gly Ala Leu Asp
        1075                1080                1085            
Thr Ser Ser Pro Gly Thr Gln His Pro Phe Ala Pro Glu Thr Pro Ile
    1090                1095                1100                
Pro Gly Ala Ser Trp Ser Ile Ser Pro Thr Thr Pro Gly Gly Leu Pro
1105                1110                1115                1120
Trp Gly Trp Thr Gln Thr Pro Thr Pro Val Pro Glu Asp Lys Gly Gln
                1125                1130                1135    
Pro Gly Glu Asp Leu Arg His Pro Gly Thr Ser Leu Pro Ala Ala Ser
            1140                1145                1150        
Pro Val Thr
        1155


<210> 8657
<211> 1226
<212> PRT
<213> Homo sapiens

<400> 8657
Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys
 1               5                  10                  15      
Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser
            20                  25                  30          
Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe
        35                  40                  45              
Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser
    50                  55                  60                  
Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser
65                  70                  75                  80  
Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu
                85                  90                  95      
Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val
            100                 105                 110         
Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val
        115                 120                 125             
Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe
    130                 135                 140                 
Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly
145                 150                 155                 160 
Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly
                165                 170                 175     
Leu Ile Arg Thr Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg
            180                 185                 190         
Gly Gln Gln Glu Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg
        195                 200                 205             
Arg Glu Ala Val Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His
    210                 215                 220                 
Asn Glu Ala Phe Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val
225                 230                 235                 240 
Gly Asp Gln Leu Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro
                245                 250                 255     
Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val
            260                 265                 270         
Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met
        275                 280                 285             
Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile
    290                 295                 300                 
Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu
305                 310                 315                 320 
Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys
                325                 330                 335     
Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His
            340                 345                 350         
His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly
        355                 360                 365             
Met Gln Gly Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser
    370                 375                 380                 
Cys Ala Leu Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala
385                 390                 395                 400 
His Glu Thr Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn
                405                 410                 415     
Gly Cys Ala Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val
            420                 425                 430         
Gln Ala Ala Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu
        435                 440                 445             
Leu Ser Arg Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe
    450                 455                 460                 
Asp Pro Ala Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser
465                 470                 475                 480 
Met Asp Glu Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys
                485                 490                 495     
Leu Ala Phe Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His
            500                 505                 510         
Pro Asp Asn Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp
        515                 520                 525             
Gly Thr Glu Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile
    530                 535                 540                 
Trp Lys Ser Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser
545                 550                 555                 560 
Trp Thr Lys Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg
                565                 570                 575     
Ser Arg Ser Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg
            580                 585                 590         
Pro Cys Leu Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu
        595                 600                 605             
Cys Pro Gly Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg
    610                 615                 620                 
Asn Ser Tyr Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr
625                 630                 635                 640 
Glu Pro Asp Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala
                645                 650                 655     
Asp Thr Gly Asp Val Val Phe Met Asn Gln Val Val His Asp Gly Thr
            660                 665                 670         
Arg Cys Ser Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys
        675                 680                 685             
Val Pro Val Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp
    690                 695                 700                 
Lys Cys Gly Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys
705                 710                 715                 720 
Gly Thr Leu Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val
                725                 730                 735     
Gln Ile Pro Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys
            740                 745                 750         
Ser Pro His Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile
        755                 760                 765             
Leu Asn Pro Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met
    770                 775                 780                 
Gly Leu Glu Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys
785                 790                 795                 800 
Thr Ser Gly Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro
                805                 810                 815     
Thr Glu Gly Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His
            820                 825                 830         
Glu Asp Leu Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu
        835                 840                 845             
Met Asp Thr Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys
    850                 855                 860                 
Ala Cys Gly Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg
865                 870                 875                 880 
Arg Asp His His Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg
                885                 890                 895     
Pro Lys Pro Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro
            900                 905                 910         
Val Trp Val Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys
        915                 920                 925             
Leu Gly Val Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn
    930                 935                 940                 
Gly Thr His Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro
945                 950                 955                 960 
Glu Ala Arg Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg
                965                 970                 975     
Leu Gly Ala Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln
            980                 985                 990         
Gln Arg Gln Val Val Cys Arg Thr Asn Ala Asn Ser Leu Gly His Cys
        995                 1000                1005            
Glu Gly Asp Arg Pro Asp Thr Val Gln Val Cys Ser Leu Pro Ala Cys
    1010                1015                1020                
Gly Gly Asn His Gln Asn Ser Thr Val Arg Ala Asp Val Trp Glu Leu
1025                1030                1035                1040
Gly Thr Pro Glu Gly Gln Trp Val Pro Gln Ser Glu Pro Leu His Pro
                1045                1050                1055    
Ile Asn Lys Ile Ser Ser Thr Glu Pro Cys Thr Gly Asp Arg Ser Val
            1060                1065                1070        
Phe Cys Gln Met Glu Val Leu Asp Arg Tyr Cys Ser Ile Pro Gly Tyr
        1075                1080                1085            
His Arg Leu Cys Cys Val Ser Cys Ile Lys Lys Ala Ser Gly Pro Asn
    1090                1095                1100                
Pro Gly Pro Asp Pro Gly Pro Thr Ser Leu Pro Pro Phe Ser Thr Pro
1105                1110                1115                1120
Gly Ser Pro Leu Pro Gly Pro Gln Asp Pro Ala Asp Ala Ala Glu Pro
                1125                1130                1135    
Pro Gly Lys Pro Thr Gly Ser Glu Asp His Gln His Gly Arg Ala Thr
            1140                1145                1150        
Gln Leu Pro Gly Ala Leu Asp Thr Ser Ser Pro Gly Thr Gln His Pro
        1155                1160                1165            
Phe Ala Pro Glu Thr Pro Ile Pro Gly Ala Ser Trp Ser Ile Ser Pro
    1170                1175                1180                
Thr Thr Pro Gly Gly Leu Pro Trp Gly Trp Thr Gln Thr Pro Thr Pro
1185                1190                1195                1200
Val Pro Glu Asp Lys Gly Gln Pro Gly Glu Asp Leu Arg His Pro Gly
                1205                1210                1215    
Thr Ser Leu Pro Ala Ala Ser Pro Val Thr
            1220                1225    


<210> 8658
<211> 184
<212> PRT
<213> Homo sapiens

<400> 8658
Met Gln Phe Thr Ser Ile Ser Asn Ser Leu Thr Ser Thr Ala Ala Ile
 1               5                  10                  15      
Gly Leu Ser Phe Thr Thr Ser Thr Thr Thr Thr Ala Thr Phe Thr Thr
            20                  25                  30          
Asn Thr Thr Thr Thr Ile Thr Ser Gly Phe Thr Val Asn Gln Asn Gln
        35                  40                  45              
Leu Leu Ser Arg Gly Phe Glu Asn Leu Val Pro Tyr Thr Ser Thr Val
    50                  55                  60                  
Ser Val Val Ala Thr Pro Val Met Thr Tyr Gly His Leu Glu Gly Leu
65                  70                  75                  80  
Ile Asn Glu Trp Asn Leu Glu Leu Glu Asp Gln Glu Lys Tyr Phe Leu
                85                  90                  95      
Leu Gln Ala Thr Gln Val Asn Ala Trp Asp His Thr Leu Ile Glu Asn
            100                 105                 110         
Gly Glu Met Ile Arg Ile Leu His Gly Glu Val Asn Lys Val Lys Leu
        115                 120                 125             
Asp Gln Lys Arg Leu Glu Gln Glu Leu Asp Phe Ile Leu Ser Gln Gln
    130                 135                 140                 
Gln Glu Leu Glu Phe Leu Leu Thr Tyr Leu Glu Glu Ser Thr Arg Asp
145                 150                 155                 160 
Gln Ser Gly Leu His Tyr Leu Gln Asp Ala Asp Glu Glu His Val Glu
                165                 170                 175     
Ile Ser Thr Arg Ser Ala Glu Phe
            180                 


<210> 8659
<211> 72
<212> PRT
<213> Homo sapiens

<400> 8659
Met Gln Phe Thr Ser Ile Ser Asn Ser Leu Thr Ser Thr Ala Ala Ile
 1               5                  10                  15      
Gly Leu Ser Phe Thr Thr Ser Thr Thr Thr Thr Ala Thr Phe Thr Thr
            20                  25                  30          
Asn Thr Thr Thr Thr Ile Thr Ser Gly Phe Thr Val Asn Gln Asn Gln
        35                  40                  45              
Leu Leu Ser Arg Gly Phe Glu Asn Leu Val Pro Tyr Thr Ser Thr Val
    50                  55                  60                  
Arg Phe Val Phe Tyr Met Glu Lys
65                  70          


<210> 8660
<211> 501
<212> PRT
<213> Homo sapiens

<400> 8660
Met Ile Ile Ser His Phe Pro Lys Cys Val Ala Val Phe Ala Leu Leu
 1               5                  10                  15      
Ala Leu Ser Val Gly Ala Leu Asp Thr Phe Ile Ala Ala Val Tyr Glu
            20                  25                  30          
His Ala Val Ile Leu Pro Asn Arg Thr Glu Thr Pro Val Ser Lys Glu
        35                  40                  45              
Glu Ala Leu Leu Leu Met Asn Lys Asn Ile Asp Val Leu Glu Lys Ala
    50                  55                  60                  
Val Lys Leu Ala Ala Lys Gln Gly Ala His Ile Ile Val Thr Pro Glu
65                  70                  75                  80  
Asp Gly Ile Tyr Gly Trp Ile Phe Thr Arg Glu Ser Ile Tyr Pro Tyr
                85                  90                  95      
Leu Glu Asp Ile Pro Asp Pro Gly Val Asn Trp Ile Pro Cys Arg Asp
            100                 105                 110         
Pro Trp Arg Phe Gly Asn Thr Pro Val Gln Gln Arg Leu Ser Cys Leu
        115                 120                 125             
Ala Lys Asp Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys
    130                 135                 140                 
Pro Cys Asn Ala Ser Asp Ser Gln Cys Pro Pro Asp Gly Arg Tyr Gln
145                 150                 155                 160 
Tyr Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Leu Ala Arg
                165                 170                 175     
Tyr His Lys Tyr Asn Leu Phe Ala Pro Glu Ile Gln Phe Asp Phe Pro
            180                 185                 190         
Lys Asp Ser Glu Leu Val Thr Phe Asp Thr Pro Phe Gly Lys Phe Gly
        195                 200                 205             
Ile Phe Thr Cys Phe Asp Ile Phe Ser His Asp Pro Ala Ala Val Val
    210                 215                 220                 
Val Asp Glu Val Ser Ile Asp Ser Ile Leu Tyr Pro Thr Ala Trp Tyr
225                 230                 235                 240 
Asn Thr Leu Pro Leu Leu Ser Ala Val Pro Phe His Ser Ala Trp Ala
                245                 250                 255     
Lys Ala Met Gly Val Asn Leu Leu Ala Ala Asn Thr His Asn Thr Ser
            260                 265                 270         
Met His Met Thr Gly Ser Gly Ile Tyr Ala Pro Glu Ala Val Lys Val
        275                 280                 285             
Tyr His Tyr Asp Met Glu Thr Glu Ser Gly Gln Leu Leu Leu Ser Glu
    290                 295                 300                 
Leu Lys Ser Arg Pro Arg Arg Glu Pro Thr Tyr Pro Ala Ala Val Asp
305                 310                 315                 320 
Trp His Ala Tyr Ala Ser Ser Val Lys Pro Phe Ser Ser Glu Gln Ser
                325                 330                 335     
Asp Phe Leu Gly Met Ile Tyr Phe Asp Glu Phe Thr Phe Thr Lys Leu
            340                 345                 350         
Lys Arg Asn Thr Gly Asn Tyr Thr Ala Cys Gln Lys Asp Leu Cys Cys
        355                 360                 365             
His Leu Thr Tyr Lys Met Ser Glu Lys Arg Thr Asp Glu Ile Tyr Ala
    370                 375                 380                 
Leu Gly Ala Phe Asp Gly Leu His Thr Val Glu Gly Gln Tyr Tyr Leu
385                 390                 395                 400 
Gln Ile Cys Ala Leu Leu Lys Cys Gln Thr Thr Asp Leu Glu Thr Cys
                405                 410                 415     
Gly Glu Pro Val Gly Ser Ala Phe Thr Lys Phe Glu Asp Phe Ser Leu
            420                 425                 430         
Ser Gly Thr Phe Gly Thr Arg Tyr Val Phe Pro Gln Ile Ile Leu Ser
        435                 440                 445             
Gly Ser Gln Leu Ala Pro Glu Arg His Tyr Glu Ile Ser Arg Asp Gly
    450                 455                 460                 
Arg Leu Arg Ser Arg Ser Gly Ala Pro Leu Pro Val Leu Val Met Ala
465                 470                 475                 480 
Leu Tyr Gly Arg Val Phe Glu Lys Asp Pro Pro Arg Leu Gly Gln Gly
                485                 490                 495     
Ser Gly Lys Phe Gln
            500     


<210> 8661
<211> 1163
<212> PRT
<213> Homo sapiens

<400> 8661
Met Thr Phe Gly Thr Val Leu Leu Leu Ser Val Leu Ala Ser Tyr His
 1               5                  10                  15      
Gly Phe Asn Leu Asp Val Glu Glu Pro Thr Ile Phe Gln Glu Asp Ala
            20                  25                  30          
Gly Gly Phe Gly Gln Ser Val Val Gln Phe Gly Gly Ser Arg Leu Val
        35                  40                  45              
Val Gly Ala Pro Leu Glu Val Val Ala Ala Asn Gln Thr Gly Arg Leu
    50                  55                  60                  
Tyr Asp Cys Ala Ala Ala Thr Gly Met Cys Gln Pro Ile Pro Leu His
65                  70                  75                  80  
Ile Arg Pro Glu Ala Val Asn Met Ser Leu Gly Leu Thr Leu Ala Ala
                85                  90                  95      
Ser Thr Asn Gly Ser Arg Leu Leu Ala Cys Gly Pro Thr Leu His Arg
            100                 105                 110         
Val Cys Gly Glu Asn Ser Tyr Ser Lys Gly Ser Cys Leu Leu Leu Gly
        115                 120                 125             
Ser Arg Trp Glu Ile Ile Gln Thr Val Pro Asp Ala Thr Pro Glu Cys
    130                 135                 140                 
Pro His Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser
145                 150                 155                 160 
Ile Asp Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val
                165                 170                 175     
Met Gly Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr
            180                 185                 190         
Ser Asn Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser
        195                 200                 205             
Pro Ser Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu
    210                 215                 220                 
Thr Phe Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His
225                 230                 235                 240 
His Lys Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile
                245                 250                 255     
Thr Asp Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile
            260                 265                 270         
Pro Gln Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly
        275                 280                 285             
His Ala Phe Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser
    290                 295                 300                 
Ser Ala Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala
305                 310                 315                 320 
Leu Gly Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu
                325                 330                 335     
Gly Thr Gln Ser Arg Ala Ser Ser Ser Phe Gln His Glu Met Ser Gln
            340                 345                 350         
Glu Gly Phe Ser Thr Ala Leu Thr Met Asp Gly Leu Phe Leu Gly Ala
        355                 360                 365             
Val Gly Ser Phe Ser Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro Asn
    370                 375                 380                 
Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Asp Met Arg Asp
385                 390                 395                 400 
Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly Val Gln
                405                 410                 415     
Asn Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys Ala Val
            420                 425                 430         
Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Lys Lys Ala Glu Val Thr
        435                 440                 445             
Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser Val Asp
    450                 455                 460                 
Val Asp Ser Asp Gly Ser Thr Asp Leu Ile Leu Ile Gly Ala Pro His
465                 470                 475                 480 
Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu Pro
                485                 490                 495     
Arg Gly Gln Arg Val Gln Trp Gln Cys Asp Ala Val Leu Arg Gly Glu
            500                 505                 510         
Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly
        515                 520                 525             
Asp Val Asn Glu Asp Lys Leu Ile Asp Val Ala Ile Gly Ala Pro Gly
    530                 535                 540                 
Glu Gln Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Ala Ser Glu
545                 550                 555                 560 
Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Ser Ser Gln Leu
                565                 570                 575     
Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln Asp
            580                 585                 590         
Leu Thr Gln Asp Gly Leu Met Asp Leu Ala Val Gly Ala Arg Gly Gln
        595                 600                 605             
Val Leu Leu Leu Arg Ser Leu Pro Val Leu Lys Val Gly Val Ala Met
    610                 615                 620                 
Arg Phe Ser Pro Val Glu Val Ala Lys Ala Val Tyr Arg Cys Trp Glu
625                 630                 635                 640 
Glu Lys Pro Ser Ala Leu Glu Ala Gly Asp Ala Thr Val Cys Leu Thr
                645                 650                 655     
Ile Gln Lys Ser Ser Leu Asp Gln Leu Gly Asp Ile Gln Ser Ser Val
            660                 665                 670         
Arg Phe Asp Leu Ala Leu Asp Pro Gly Arg Leu Thr Ser Arg Ala Ile
        675                 680                 685             
Phe Asn Glu Thr Lys Asn Pro Thr Leu Thr Arg Arg Lys Thr Leu Gly
    690                 695                 700                 
Leu Gly Ile His Cys Glu Thr Leu Lys Leu Leu Leu Pro Asp Cys Val
705                 710                 715                 720 
Glu Asp Val Val Ser Pro Ile Ile Leu His Leu Asn Phe Ser Leu Val
                725                 730                 735     
Arg Glu Pro Ile Pro Ser Pro Gln Asn Leu Arg Pro Val Leu Ala Val
            740                 745                 750         
Gly Ser Gln Asp Leu Phe Thr Ala Ser Leu Pro Phe Glu Lys Asn Cys
        755                 760                 765             
Gly Gln Asp Gly Leu Cys Glu Gly Asp Leu Gly Val Thr Leu Ser Phe
    770                 775                 780                 
Ser Gly Leu Gln Thr Leu Thr Val Gly Ser Ser Leu Glu Leu Asn Val
785                 790                 795                 800 
Ile Val Thr Val Trp Asn Ala Gly Glu Asp Ser Tyr Gly Thr Val Val
                805                 810                 815     
Ser Leu Tyr Tyr Pro Ala Gly Leu Ser His Arg Arg Val Ser Gly Ala
            820                 825                 830         
Gln Lys Gln Pro His Gln Ser Ala Leu Arg Leu Ala Cys Glu Thr Val
        835                 840                 845             
Pro Thr Glu Asp Glu Gly Leu Arg Ser Ser Arg Cys Ser Val Asn His
    850                 855                 860                 
Pro Ile Phe His Glu Gly Ser Asn Gly Thr Phe Ile Val Thr Phe Asp
865                 870                 875                 880 
Val Ser Tyr Lys Ala Thr Leu Gly Asp Arg Met Leu Met Arg Ala Ser
                885                 890                 895     
Ala Ser Ser Glu Asn Asn Lys Ala Ser Ser Ser Lys Ala Thr Phe Gln
            900                 905                 910         
Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Met Ile Ser Arg Gln
        915                 920                 925             
Glu Glu Ser Thr Lys Tyr Phe Asn Phe Ala Thr Ser Asp Glu Lys Lys
    930                 935                 940                 
Met Lys Glu Ala Glu His Arg Tyr Arg Val Asn Asn Leu Ser Gln Arg
945                 950                 955                 960 
Asp Leu Ala Ile Ser Ile Asn Phe Trp Val Pro Val Leu Leu Asn Gly
                965                 970                 975     
Val Ala Val Trp Asp Val Val Met Glu Ala Pro Ser Gln Ser Leu Pro
            980                 985                 990         
Cys Val Ser Glu Arg Lys Pro Pro Gln His Ser Asp Phe Leu Thr Gln
        995                 1000                1005            
Ile Ser Arg Ser Pro Met Leu Asp Cys Ser Ile Ala Asp Cys Leu Gln
    1010                1015                1020                
Phe Arg Cys Asp Val Pro Ser Phe Ser Val Gln Glu Glu Leu Asp Phe
1025                1030                1035                1040
Thr Leu Lys Gly Asn Leu Ser Phe Gly Trp Val Arg Glu Thr Leu Gln
                1045                1050                1055    
Lys Lys Val Leu Val Val Ser Val Ala Glu Ile Thr Phe Asp Thr Ser
            1060                1065                1070        
Val Tyr Ser Gln Leu Pro Gly Gln Glu Ala Phe Met Arg Ala Gln Met
        1075                1080                1085            
Glu Met Val Leu Glu Glu Asp Glu Val Tyr Asn Ala Ile Pro Ile Ile
    1090                1095                1100                
Met Gly Ser Ser Val Gly Ala Leu Leu Leu Leu Ala Leu Ile Thr Ala
1105                1110                1115                1120
Thr Leu Tyr Lys Ala Ser Leu Gly Phe Phe Lys Arg His Tyr Lys Glu
                1125                1130                1135    
Met Leu Glu Asp Lys Pro Glu Asp Thr Ala Thr Phe Ser Gly Asp Asp
            1140                1145                1150        
Phe Ser Cys Val Ala Pro Asn Val Pro Leu Ser
        1155                1160            


<210> 8662
<211> 797
<212> PRT
<213> Homo sapiens

<400> 8662
Met Glu Asn Gln Gly Thr Arg Thr Gln Gln Ile Arg Gln Val Leu Leu
 1               5                  10                  15      
Leu Phe Val Leu Leu Gly Met Ser Gln Ala Gly Ser Glu Thr Trp Ser
            20                  25                  30          
Phe Ser Val Ala Glu Glu Met Gln Ser Gly Ser Phe Val Gly Asn Leu
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Lys Val Arg Glu Leu Ser Ser Arg Gly Ala
    50                  55                  60                  
Arg Val Val Ser Asn Asp Lys Lys Gln Arg Leu Gln Leu Asp Ile Asn
65                  70                  75                  80  
Thr Gly Asp Leu Leu Leu Ser Glu Thr Leu Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Gly Ser Ile Glu Pro Cys Val Leu His Leu Gln Val Leu Met Gln Asn
            100                 105                 110         
Pro Thr Gln Phe Leu Gln Ile Glu Leu Gln Val Arg Asp Ile Asn Asp
        115                 120                 125             
His Ser Pro Ile Phe Ser Glu Lys Gln Met Leu Leu Glu Ile Pro Glu
    130                 135                 140                 
Asn Ser Pro Val Gly Ala Val Phe Leu Leu Glu Ser Ala Lys Asp Leu
145                 150                 155                 160 
Asp Val Gly Ile Asn Ala Val Lys Ser Tyr Thr Ile Ser Pro Asn Ser
                165                 170                 175     
His Phe His Ile Lys Met Arg Val Ile Pro Asp Asn Arg Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Asp Lys Ala Leu Asp Tyr Glu Glu Leu Pro Glu Leu
        195                 200                 205             
Ser Phe Ile Leu Ser Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly
    210                 215                 220                 
Thr Ala Leu Val Arg Val Val Val Val Asp Ile Asn Asp Asn Ser Pro
225                 230                 235                 240 
Glu Phe Glu Gln Ala Phe Tyr Glu Val Lys Ile Arg Glu Asn Ser Ile
                245                 250                 255     
Leu Gly Ser Leu Ile Leu Ile Val Ser Ala Trp Asp Leu Asp Ser Gly
            260                 265                 270         
Thr Asn Gly Glu Ile Cys Tyr Thr Phe Ser His Ala Ser Glu Asp Ile
        275                 280                 285             
Arg Lys Thr Phe Glu Ile Asn Gln Lys Ser Gly Glu Ile Thr Leu Arg
    290                 295                 300                 
Ala Pro Leu Asp Phe Glu Thr Ile Glu Ser Tyr Ser Ile Ile Ile Gln
305                 310                 315                 320 
Ala Thr Asp Gly Gly Gly Leu Phe Gly Lys Ser Thr Val Ile Ile His
                325                 330                 335     
Val Ile Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Val Ser Ser Ile
            340                 345                 350         
Thr Ser Pro Ile Pro Glu Asn Thr Pro Glu Thr Val Val Met Val Phe
        355                 360                 365             
Ser Ile Gln Asp Ile Asp Ser Gly Asp Asn Gly Arg Ile Val Cys Ser
    370                 375                 380                 
Ile Pro Glu Asp Leu Pro Phe Val Leu Lys Ser Ser Val Glu Asn Tyr
385                 390                 395                 400 
Tyr Thr Leu Glu Thr Glu Arg Pro Leu Asp Arg Glu Ser Thr Ala Glu
                405                 410                 415     
Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Ile Pro Arg Leu Lys
            420                 425                 430         
Thr Glu His Asn Thr Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala
        435                 440                 445             
Pro Thr Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn
    450                 455                 460                 
Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser
465                 470                 475                 480 
Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Pro Gln Asp Leu
                485                 490                 495     
His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Thr Asp Asn Gly His
            500                 505                 510         
Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Asp
        515                 520                 525             
Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu
    530                 535                 540                 
Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe
545                 550                 555                 560 
Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val
                565                 570                 575     
Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val
            580                 585                 590         
Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys
        595                 600                 605             
Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val
    610                 615                 620                 
Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu
625                 630                 635                 640 
Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala
                645                 650                 655     
Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro
            660                 665                 670         
Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val
        675                 680                 685             
Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser
    690                 695                 700                 
Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala
705                 710                 715                 720 
Ser Val Gly Ser Cys Ser Val Pro Lys Gly Pro Phe Pro Gly His Leu
                725                 730                 735     
Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu
            740                 745                 750         
Val Cys Leu Thr Gly Gly Ser Glu Thr Asn Glu Phe Lys Phe Leu Lys
        755                 760                 765             
Pro Val Ile Pro Asn Ile Gln Ala Lys Gly Leu Gly Lys Asn Ser Glu
    770                 775                 780                 
Glu Asn Ser Thr Phe Arg Asn Ser Phe Gly Phe Asn Phe
785                 790                 795         


<210> 8663
<211> 478
<212> PRT
<213> Homo sapiens

<400> 8663
Met Ala His Val Pro Ala Arg Thr Ser Pro Gly Pro Gly Pro Gln Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Pro Leu Phe Leu Leu Leu Leu Arg Asp Val Ala
            20                  25                  30          
Gly Ser His Arg Ala Pro Ala Trp Ser Ala Leu Pro Ala Ala Ala Asp
        35                  40                  45              
Gly Leu Gln Gly Asp Arg Asp Leu Gln Arg His Pro Gly Asp Ala Ala
    50                  55                  60                  
Ala Thr Leu Gly Pro Ser Ala Gln Asp Met Val Ala Val His Met His
65                  70                  75                  80  
Arg Leu Tyr Glu Lys Tyr Ser Arg Gln Gly Ala Arg Pro Gly Gly Gly
                85                  90                  95      
Asn Thr Val Arg Ser Phe Arg Ala Arg Leu Glu Val Val Asp Gln Lys
            100                 105                 110         
Ala Val Tyr Phe Phe Asn Leu Thr Ser Met Gln Asp Ser Glu Met Ile
        115                 120                 125             
Leu Thr Ala Thr Phe His Phe Tyr Ser Glu Pro Pro Arg Trp Pro Arg
    130                 135                 140                 
Ala Leu Glu Val Leu Cys Lys Pro Arg Ala Lys Asn Ala Ser Gly Arg
145                 150                 155                 160 
Pro Leu Pro Leu Gly Pro Pro Thr Arg Gln His Leu Leu Phe Arg Ser
                165                 170                 175     
Leu Ser Gln Asn Thr Ala Thr Gln Gly Leu Leu Arg Gly Ala Met Ala
            180                 185                 190         
Leu Ala Pro Pro Pro Arg Gly Leu Trp Gln Ala Lys Asp Ile Ser Pro
        195                 200                 205             
Ile Val Lys Ala Ala Arg Arg Asp Gly Glu Leu Leu Leu Ser Ala Gln
    210                 215                 220                 
Leu Asp Ser Glu Glu Arg Asp Pro Gly Val Pro Arg Pro Ser Pro Tyr
225                 230                 235                 240 
Ala Pro Tyr Ile Leu Val Tyr Ala Asn Asp Leu Ala Ile Ser Glu Pro
                245                 250                 255     
Asn Ser Val Ala Val Thr Leu Gln Arg Tyr Asp Pro Phe Pro Ala Gly
            260                 265                 270         
Asp Pro Glu Pro Arg Ala Ala Pro Asn Asn Ser Ala Asp Pro Arg Val
        275                 280                 285             
Arg Arg Ala Ala Gln Ala Thr Gly Pro Leu Gln Asp Asn Glu Leu Pro
    290                 295                 300                 
Gly Leu Asp Glu Arg Pro Pro Arg Ala His Ala Gln His Phe His Lys
305                 310                 315                 320 
His Gln Leu Trp Pro Ser Pro Phe Arg Ala Leu Lys Pro Arg Pro Gly
                325                 330                 335     
Arg Lys Asp Arg Arg Lys Lys Gly Gln Glu Val Phe Met Ala Ala Ser
            340                 345                 350         
Gln Val Leu Asp Phe Asp Glu Lys Thr Met Gln Lys Ala Arg Arg Lys
        355                 360                 365             
Gln Trp Asp Glu Pro Arg Val Cys Ser Arg Arg Tyr Leu Lys Val Asp
    370                 375                 380                 
Phe Ala Asp Ile Gly Trp Asn Glu Trp Ile Ile Ser Pro Lys Ser Phe
385                 390                 395                 400 
Asp Ala Tyr Tyr Cys Ala Gly Ala Cys Glu Phe Pro Met Pro Lys Ile
                405                 410                 415     
Val Arg Pro Ser Asn His Ala Thr Ile Gln Ser Ile Val Arg Ala Val
            420                 425                 430         
Gly Ile Ile Pro Gly Ile Pro Glu Pro Cys Cys Val Pro Asp Lys Met
        435                 440                 445             
Asn Ser Leu Gly Val Leu Phe Leu Asp Glu Asn Arg Asn Val Val Leu
    450                 455                 460                 
Lys Val Tyr Pro Asn Met Ser Val Asp Thr Cys Ala Cys Arg
465                 470                 475             


<210> 8664
<211> 1775
<212> PRT
<213> Homo sapiens

<400> 8664
Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Ser Phe Ala Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu
            20                  25                  30          
Asp Pro Gly Leu Ser Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln
        35                  40                  45              
Ala Pro Gln Gly Ser Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala
    50                  55                  60                  
Asn Ile Ser Ser Ser Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val
65                  70                  75                  80  
Gly Glu Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe
                85                  90                  95      
Leu Val Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu
            100                 105                 110         
Leu Gly Asp Met Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp
        115                 120                 125             
Phe Leu Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu
    130                 135                 140                 
Leu Gly Ala Leu Val Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro
145                 150                 155                 160 
Cys Thr Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu
                165                 170                 175     
Pro Ser Leu Leu Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val
            180                 185                 190         
Gln Val Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly
        195                 200                 205             
Arg Glu Ala Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr
    210                 215                 220                 
Pro Thr Gly Glu Leu Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu
225                 230                 235                 240 
Arg Thr Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu
                245                 250                 255     
Arg Val Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln
            260                 265                 270         
Pro Glu Pro Asp Thr Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln
        275                 280                 285             
Leu Leu Leu Trp Gly Val Arg His Asn Leu Ser Trp Asp Val Gln Ala
    290                 295                 300                 
Leu Gly Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His
305                 310                 315                 320 
Cys Leu Ser Thr Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala
                325                 330                 335     
His Ile Ser Pro Arg Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys
            340                 345                 350         
Glu Asn His Leu Gly Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser
        355                 360                 365             
Ile His Leu Leu Cys Gln His Thr Lys Pro Ala Thr Pro Gln Pro His
    370                 375                 380                 
Pro Ser Thr Thr Ala Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser
385                 390                 395                 400 
Trp Ala Pro Gly Ala Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe
                405                 410                 415     
Pro Asp Glu Phe Leu Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala
            420                 425                 430         
Leu Ser Gly Ser Asn Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu
        435                 440                 445             
Leu Pro Pro Pro Thr Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu
    450                 455                 460                 
Thr Pro Asp Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp
465                 470                 475                 480 
Ala Glu Arg Leu Cys Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser
                485                 490                 495     
Asn Gln Ala Trp Val Gln His Val Cys Gln Gly Pro Thr Pro Asp Val
            500                 505                 510         
Thr Ala Ser Pro Pro Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro
        515                 520                 525             
Asp Gly Gly Ser Phe Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr
    530                 535                 540                 
Glu Val Leu Val Pro Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile
545                 550                 555                 560 
Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro
                565                 570                 575     
Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr
            580                 585                 590         
Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln
        595                 600                 605             
Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu
    610                 615                 620                 
Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala
625                 630                 635                 640 
Gln Gly Met Leu Gly Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn
                645                 650                 655     
Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu
            660                 665                 670         
Arg Thr Ile Gly Glu Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro
        675                 680                 685             
Ser Gly Phe Glu Pro Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met
    690                 695                 700                 
Glu Leu Leu Ala Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg
705                 710                 715                 720 
Glu Lys Ser Val Trp Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His
                725                 730                 735     
Met Pro Pro Glu Asn Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu
            740                 745                 750         
Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly
        755                 760                 765             
Lys Leu Gln Val Pro Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr
    770                 775                 780                 
Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile
785                 790                 795                 800 
Asp Leu Ser Pro Leu Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg
                805                 810                 815     
Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg
            820                 825                 830         
Asp Tyr Ser Pro Gly Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys
        835                 840                 845             
Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln
    850                 855                 860                 
Glu Leu Leu Trp Ala Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu
865                 870                 875                 880 
Asn Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser
                885                 890                 895     
Trp Pro Ala Ala Gly Leu Gly Pro Gly His Ala Arg His Val Leu Arg
            900                 905                 910         
Ser Leu Val Asn Gln Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg
        915                 920                 925             
Leu Gly Pro Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu
    930                 935                 940                 
Val Pro Leu Ser Asp Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu
945                 950                 955                 960 
Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu
                965                 970                 975     
Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg
            980                 985                 990         
Glu Leu Arg Val Trp Ala Pro Leu Phe Ser Gln Leu Gly Leu Arg Phe
        995                 1000                1005            
Leu Gln Glu Leu Ser Glu Pro Gln Leu Arg Ala Met Leu Pro Val Leu
    1010                1015                1020                
Gln Gly Thr Ser Val Thr Pro Ala Gln Ala Val Leu Leu Leu Gly Arg
1025                1030                1035                1040
Leu Leu Pro Arg His Asp Leu Ser Leu Glu Glu Leu Cys Ser Leu His
                1045                1050                1055    
Leu Leu Leu Pro Gly Leu Ser Pro Gln Thr Leu Gln Ala Ile Pro Arg
            1060                1065                1070        
Arg Val Leu Val Gly Ala Cys Ser Cys Leu Ala Pro Glu Leu Ser Arg
        1075                1080                1085            
Leu Ser Ala Cys Gln Thr Ala Ala Leu Leu Gln Thr Phe Arg Val Lys
    1090                1095                1100                
Asp Gly Val Lys Asn Met Gly Thr Thr Gly Ala Gly Pro Ala Val Cys
1105                1110                1115                1120
Ile Pro Gly Gln Pro Ile Pro Thr Thr Trp Pro Asp Cys Leu Leu Pro
                1125                1130                1135    
Leu Leu Pro Leu Lys Leu Leu Gln Leu Asp Ser Leu Ala Leu Leu Ala
            1140                1145                1150        
Asn Arg Arg Arg Tyr Trp Glu Leu Pro Trp Ser Glu Gln Gln Ala Gln
        1155                1160                1165            
Phe Leu Trp Lys Lys Met Gln Val Pro Thr Asn Leu Thr Leu Arg Asn
    1170                1175                1180                
Leu Gln Ala Leu Gly Thr Leu Ala Gly Gly Met Ser Cys Glu Phe Leu
1185                1190                1195                1200
Gln Gln Ile Asn Ser Met Val Asp Phe Leu Glu Val Val His Met Ile
                1205                1210                1215    
Tyr Gln Leu Pro Thr Arg Val Arg Gly Ser Leu Arg Ala Cys Ile Trp
            1220                1225                1230        
Ala Glu Leu Gln Arg Arg Met Ala Met Pro Glu Pro Glu Trp Thr Thr
        1235                1240                1245            
Val Gly Pro Glu Leu Asn Gly Leu Asp Ser Lys Leu Leu Leu Asp Leu
    1250                1255                1260                
Pro Ile Gln Leu Met Asp Arg Leu Ser Asn Glu Ser Ile Met Leu Val
1265                1270                1275                1280
Val Glu Leu Val Gln Arg Ala Pro Glu Gln Leu Leu Ala Leu Thr Pro
                1285                1290                1295    
Leu His Gln Ala Ala Leu Ala Glu Arg Ala Leu Gln Asn Leu Ala Pro
            1300                1305                1310        
Lys Glu Thr Pro Val Ser Gly Glu Val Leu Glu Thr Leu Gly Pro Leu
        1315                1320                1325            
Val Gly Phe Leu Gly Thr Glu Ser Thr Arg Gln Ile Pro Leu Gln Ile
    1330                1335                1340                
Leu Leu Ser His Leu Ser Gln Leu Gln Gly Phe Cys Leu Gly Glu Thr
1345                1350                1355                1360
Phe Ala Thr Glu Leu Gly Trp Leu Leu Leu Gln Glu Ser Val Leu Gly
                1365                1370                1375    
Lys Pro Glu Leu Trp Ser Gln Asp Glu Val Glu Gln Ala Gly Arg Leu
            1380                1385                1390        
Val Phe Thr Leu Ser Thr Glu Ala Ile Ser Leu Ile Pro Arg Glu Ala
        1395                1400                1405            
Leu Gly Pro Glu Thr Leu Glu Arg Leu Leu Glu Lys Gln Gln Ser Trp
    1410                1415                1420                
Glu Gln Ser Arg Val Gly Gln Leu Cys Arg Glu Pro Gln Leu Ala Ala
1425                1430                1435                1440
Lys Lys Ala Ala Leu Val Ala Gly Val Val Arg Pro Ala Ala Glu Asp
                1445                1450                1455    
Leu Pro Glu Pro Val Pro Asn Cys Ala Asp Val Arg Gly Thr Phe Pro
            1460                1465                1470        
Ala Ala Trp Ser Ala Thr Gln Ile Ala Glu Met Glu Leu Ser Asp Phe
        1475                1480                1485            
Glu Asp Cys Leu Thr Leu Phe Ala Gly Asp Pro Gly Leu Gly Pro Glu
    1490                1495                1500                
Glu Leu Arg Ala Ala Met Gly Lys Ala Lys Gln Leu Trp Gly Pro Pro
1505                1510                1515                1520
Arg Gly Phe Arg Pro Glu Gln Ile Leu Gln Leu Gly Arg Leu Leu Ile
                1525                1530                1535    
Gly Leu Gly Asp Arg Glu Leu Gln Glu Leu Ile Leu Val Asp Trp Gly
            1540                1545                1550        
Val Leu Ser Thr Leu Gly Gln Ile Asp Gly Trp Ser Thr Thr Gln Leu
        1555                1560                1565            
Arg Ile Val Val Ser Ser Phe Leu Arg Gln Ser Gly Arg His Val Ser
    1570                1575                1580                
His Leu Asp Phe Val His Leu Thr Ala Leu Gly Tyr Thr Leu Cys Gly
1585                1590                1595                1600
Leu Arg Pro Glu Glu Leu Gln His Ile Ser Ser Trp Glu Phe Ser Gln
                1605                1610                1615    
Ala Ala Leu Phe Leu Gly Thr Leu His Leu Gln Cys Ser Glu Glu Gln
            1620                1625                1630        
Leu Glu Val Leu Ala His Leu Leu Val Leu Pro Gly Gly Phe Gly Pro
        1635                1640                1645            
Ile Ser Asn Trp Gly Pro Glu Ile Phe Thr Glu Ile Gly Thr Ile Ala
    1650                1655                1660                
Ala Gly Ile Pro Asp Leu Ala Leu Ser Ala Leu Leu Arg Gly Gln Ile
1665                1670                1675                1680
Gln Gly Val Thr Pro Leu Ala Ile Ser Val Ile Pro Pro Pro Lys Phe
                1685                1690                1695    
Ala Val Val Phe Ser Pro Ile Gln Leu Ser Ser Leu Thr Ser Ala Gln
            1700                1705                1710        
Ala Val Ala Val Thr Pro Glu Gln Met Ala Phe Leu Ser Pro Glu Gln
        1715                1720                1725            
Arg Arg Ala Val Ala Trp Ala Gln His Glu Gly Lys Glu Ser Pro Glu
    1730                1735                1740                
Gln Gln Gly Arg Ser Thr Ala Trp Gly Leu Gln Asp Trp Ser Arg Pro
1745                1750                1755                1760
Ser Trp Ser Leu Val Leu Thr Ile Ser Phe Leu Gly His Leu Leu
                1765                1770                1775


<210> 8665
<211> 424
<212> PRT
<213> Homo sapiens

<400> 8665
Met Pro Ser Glu Ser Gly Ala Glu Arg Arg Asp Arg Ala Ala Ala Gln
 1               5                  10                  15      
Val Gly Thr Ala Ala Ala Thr Ala Val Ala Thr Ala Ala Pro Ala Gly
            20                  25                  30          
Gly Gly Pro Asp Pro Glu Ala Leu Ser Ala Phe Pro Gly Arg His Leu
        35                  40                  45              
Ser Gly Leu Ser Trp Pro Gln Val Lys Arg Leu Asp Ala Leu Leu Ser
    50                  55                  60                  
Glu Pro Ile Pro Ile His Gly Arg Gly Asn Phe Pro Thr Leu Ser Val
65                  70                  75                  80  
Gln Pro Arg Gln Ile Val Gln Val Val Arg Ser Thr Leu Glu Glu Gln
                85                  90                  95      
Gly Leu His Val His Ser Val Arg Leu His Gly Ser Ala Ala Ser His
            100                 105                 110         
Val Leu His Pro Glu Ser Gly Leu Gly Tyr Lys Asp Leu Asp Leu Val
        115                 120                 125             
Phe Arg Val Asp Leu Arg Ser Glu Ala Ser Phe Gln Leu Thr Lys Ala
    130                 135                 140                 
Val Val Leu Ala Cys Leu Leu Asp Phe Leu Pro Ala Gly Val Ser Arg
145                 150                 155                 160 
Ala Lys Ile Thr Pro Leu Thr Leu Lys Glu Ala Tyr Val Gln Lys Leu
                165                 170                 175     
Val Lys Val Cys Thr Asp Ser Asp Arg Trp Ser Leu Ile Ser Leu Ser
            180                 185                 190         
Asn Lys Ser Gly Lys Asn Val Glu Leu Lys Phe Val Asp Ser Val Arg
        195                 200                 205             
Arg Gln Phe Glu Phe Ser Ile Asp Ser Phe Gln Ile Ile Leu Asp Ser
    210                 215                 220                 
Leu Leu Leu Phe Gly Gln Cys Ser Ser Thr Pro Met Ser Glu Ala Phe
225                 230                 235                 240 
His Pro Thr Val Thr Gly Glu Ser Leu Tyr Gly Asp Phe Thr Glu Ala
                245                 250                 255     
Leu Glu His Leu Arg His Arg Val Ile Ala Thr Arg Ser Pro Glu Glu
            260                 265                 270         
Ile Arg Gly Gly Gly Leu Leu Lys Tyr Cys His Leu Leu Val Arg Gly
        275                 280                 285             
Phe Arg Pro Arg Pro Ser Thr Asp Val Arg Ala Leu Gln Arg Tyr Met
    290                 295                 300                 
Cys Ser Arg Phe Phe Ile Asp Phe Pro Asp Leu Val Glu Gln Arg Arg
305                 310                 315                 320 
Thr Leu Glu Arg Tyr Leu Glu Ala His Phe Gly Gly Ala Asp Ala Ala
                325                 330                 335     
Arg Arg Tyr Ala Cys Leu Val Thr Leu His Arg Val Val Asn Glu Ser
            340                 345                 350         
Thr Val Cys Leu Met Asn His Glu Arg Arg Gln Thr Leu Asp Leu Ile
        355                 360                 365             
Ala Ala Leu Ala Leu Gln Ala Leu Ala Glu Gln Gly Pro Ala Ala Thr
    370                 375                 380                 
Ala Ala Leu Ala Trp Arg Pro Pro Gly Thr Asp Gly Val Val Pro Ala
385                 390                 395                 400 
Thr Val Asn Tyr Tyr Val Thr Pro Val Gln Pro Leu Leu Ala His Ala
                405                 410                 415     
Tyr Pro Thr Trp Leu Pro Cys Asn
            420                 


<210> 8666
<211> 101
<212> PRT
<213> Homo sapiens

<400> 8666
Met Ser Gly Ser Cys Arg Phe Cys Ser Ser Arg Ala Leu Ser Ser Ala
 1               5                  10                  15      
Gly Ala Ser Lys Ala Ser Leu Ser Ser Phe Thr Thr Gly Ala Ala Thr
            20                  25                  30          
Ser Ala Thr Gly Arg Ser Ser Thr Thr Ala Pro Thr Arg Ala Gln Leu
        35                  40                  45              
Arg Ala Ala Arg Thr Ser Ser Ala Ser Ser Thr Gln Ser Leu Ser Leu
    50                  55                  60                  
Arg Ser Arg Gly Ser Ser Ala Ala Ala Asp Ser Ser Arg Lys Pro Arg
65                  70                  75                  80  
Val Arg Arg Ala Ser Cys Glu Pro Ala Asn Gly Ser Gly Arg Ser Arg
                85                  90                  95      
Met Arg Cys Val Gly
            100     


<210> 8667
<211> 1624
<212> PRT
<213> Homo sapiens

<400> 8667
Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr
 1               5                  10                  15      
Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro
            20                  25                  30          
Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg
        35                  40                  45              
Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe
    50                  55                  60                  
Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu
65                  70                  75                  80  
Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala
                85                  90                  95      
Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala
            100                 105                 110         
Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys
        115                 120                 125             
Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu
    130                 135                 140                 
Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu
145                 150                 155                 160 
Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp
                165                 170                 175     
Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu
            180                 185                 190         
Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile
        195                 200                 205             
Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His
    210                 215                 220                 
Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr
225                 230                 235                 240 
Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu
                245                 250                 255     
Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys
            260                 265                 270         
Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp
        275                 280                 285             
Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu
    290                 295                 300                 
Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe
305                 310                 315                 320 
Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro
                325                 330                 335     
Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His
            340                 345                 350         
Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His
        355                 360                 365             
Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His
    370                 375                 380                 
Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe
385                 390                 395                 400 
Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala
                405                 410                 415     
Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly
            420                 425                 430         
Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val
        435                 440                 445             
Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly
    450                 455                 460                 
Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys
465                 470                 475                 480 
Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro
                485                 490                 495     
His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln
            500                 505                 510         
Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala
        515                 520                 525             
Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys
    530                 535                 540                 
Ser Ser Pro Cys Glu Ala Ser Leu Leu Leu Arg Met Ser Trp Leu Ile
545                 550                 555                 560 
Arg Gly Val Leu Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys
                565                 570                 575     
Thr Gly Lys Glu Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu
            580                 585                 590         
Gly Leu Ser Leu Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser
        595                 600                 605             
Asp Arg Phe Trp Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg
    610                 615                 620                 
Ala Ile Val Ala Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu
625                 630                 635                 640 
Thr Ile Ser Gly Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser
                645                 650                 655     
Arg Asn Leu Phe Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu
            660                 665                 670         
Asn Ser Pro Arg Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu
        675                 680                 685             
Phe Thr Thr Cys Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln
    690                 695                 700                 
Cys Asn Asn Ala Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser
705                 710                 715                 720 
Glu Gly Pro Leu Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp
                725                 730                 735     
Thr Tyr Ser Ile Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys
            740                 745                 750         
Asn Thr Met Met Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn
        755                 760                 765             
Leu Glu Lys Asp Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu
    770                 775                 780                 
Asp Ala Cys Pro Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly
785                 790                 795                 800 
Glu Asn Asn Val Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His
                805                 810                 815     
Glu Trp Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe
            820                 825                 830         
Lys Met Lys Asp Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly
        835                 840                 845             
Gly Gly Arg Ala Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg
    850                 855                 860                 
Leu Glu Asn Asn Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala
865                 870                 875                 880 
Ala Gly Gly Gly Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala
                885                 890                 895     
Gly Lys Ser Leu Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln
            900                 905                 910         
Ala Met Lys Lys Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly
        915                 920                 925             
Gly Gly Gly Cys Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly
    930                 935                 940                 
Asn Ala Ala Ser Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val
945                 950                 955                 960 
Ser Phe Ile Ser Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val
                965                 970                 975     
Met Glu Gly His Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser
            980                 985                 990         
His Cys Glu Val Asp Glu Cys His Met Asp Pro Glu Ser His Lys Val
        995                 1000                1005            
Ile Cys Phe Cys Asp His Gly Thr Val Leu Ala Glu Asp Gly Val Ser
    1010                1015                1020                
Cys Ile Val Ser Pro Thr Pro Glu Pro His Leu Pro Leu Ser Leu Ile
1025                1030                1035                1040
Leu Ser Val Val Thr Ser Ala Leu Val Ala Ala Leu Val Leu Ala Phe
                1045                1050                1055    
Ser Gly Ile Met Ile Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala
            1060                1065                1070        
Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg
        1075                1080                1085            
Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly
    1090                1095                1100                
Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile
1105                1110                1115                1120
Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu
                1125                1130                1135    
Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala
            1140                1145                1150        
Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe
        1155                1160                1165            
Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val
    1170                1175                1180                
Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu
1185                1190                1195                1200
Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg
                1205                1210                1215    
Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His
            1220                1225                1230        
Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His
        1235                1240                1245            
Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro
    1250                1255                1260                
Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp
1265                1270                1275                1280
Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro
                1285                1290                1295    
Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser
            1300                1305                1310        
Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser
        1315                1320                1325            
Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu
    1330                1335                1340                
Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly
1345                1350                1355                1360
Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp
                1365                1370                1375    
Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln
            1380                1385                1390        
Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu
        1395                1400                1405            
Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly
    1410                1415                1420                
Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg
1425                1430                1435                1440
Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala
                1445                1450                1455    
Ala Lys Lys Pro Thr Ala Ala Glu Ile Ser Val Arg Val Pro Arg Gly
            1460                1465                1470        
Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn
        1475                1480                1485            
Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr
    1490                1495                1500                
Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr
1505                1510                1515                1520
Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn
                1525                1530                1535    
Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly
            1540                1545                1550        
Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala
        1555                1560                1565            
Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly
    1570                1575                1580                
Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala
1585                1590                1595                1600
Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys
                1605                1610                1615    
Asn Ser Met Asn Gln Pro Gly Pro
            1620                


<210> 8668
<211> 832
<212> PRT
<213> Homo sapiens

<400> 8668
Met Ser Ala Arg Glu Val Ala Val Leu Leu Leu Trp Leu Ser Cys Tyr
 1               5                  10                  15      
Gly Ser Ala Leu Trp Arg Tyr Ser Thr Asn Ser Pro Asn Tyr Arg Ile
            20                  25                  30          
Phe Ser Thr Arg Ser Thr Ile Lys Leu Glu Tyr Glu Gly Thr Leu Phe
        35                  40                  45              
Thr Glu Trp Ser Val Pro Glu Thr Cys Phe Val Leu Asn Lys Ser Ser
    50                  55                  60                  
Pro Thr Thr Glu Leu Arg Cys Ser Ser Pro Gly Val His Ala Ile Lys
65                  70                  75                  80  
Pro Ile Val Thr Gly Pro Asp Glu Glu Glu Arg Tyr Leu Phe Val Glu
                85                  90                  95      
Ser Ser His Thr Cys Phe Leu Trp Tyr Tyr Arg Val Arg His Phe Phe
            100                 105                 110         
Asn Asn Phe Thr Gln Leu Ile Thr Val Trp Ala Tyr Asp Pro Glu Ser
        115                 120                 125             
Ala Asp Pro Asp Glu Leu Leu Gly Asn Ala Glu Glu Pro Ser Ile Asn
    130                 135                 140                 
Ser Ile Val Leu Ser Thr Gln Met Ala Thr Leu Gly Gln Lys Pro Val
145                 150                 155                 160 
Ile His Thr Val Leu Lys Arg Lys Val Tyr Ser Ser Asn Glu Lys Met
                165                 170                 175     
Arg Arg Gly Thr Trp Arg Ile Val Val Pro Met Thr Lys Asp Asp Ala
            180                 185                 190         
Leu Lys Glu Ile Arg Gly Asn Gln Val Thr Phe Gln Asp Cys Phe Ile
        195                 200                 205             
Ala Asp Phe Leu Ile Leu Leu Thr Phe Pro Leu Leu Thr Ile Pro Glu
    210                 215                 220                 
Ile Pro Gly Tyr Leu Pro Ile Ser Ser Pro Arg Gly Ser Gln Leu Met
225                 230                 235                 240 
Ala Ser Trp Asp Ala Cys Val Val Ala Ser Ala Val Leu Val Thr Asp
                245                 250                 255     
Met Glu Thr Phe His Thr Thr Asp Ser Phe Lys Ser Trp Thr Arg Ile
            260                 265                 270         
Arg Val Pro Pro Asp Ile Leu Ser Asp Asp Glu Arg Arg Ser Val Ala
        275                 280                 285             
His Val Ile Leu Ser Arg Asp Gly Ile Val Phe Leu Ile Asn Gly Val
    290                 295                 300                 
Leu Tyr Ile Lys Ser Phe Arg Gly Phe Ile Arg Leu Gly Gly Ile Val
305                 310                 315                 320 
Asn Leu Pro Asp Gly Gly Ile Thr Gly Ile Ser Ser Arg Lys Trp Cys
                325                 330                 335     
Trp Val Asn Tyr Leu Leu Lys Ala Lys Gly Arg Arg Ser Thr Phe Ala
            340                 345                 350         
Val Trp Thr Glu Asn Glu Ile Tyr Leu Gly Ser Ile Leu Leu Lys Phe
        355                 360                 365             
Ala Arg Leu Val Thr Thr Thr Glu Leu Lys Asn Ile Leu Ser Leu Ser
    370                 375                 380                 
Val Thr Ala Thr Leu Thr Ile Asp Arg Val Glu Tyr Thr Gly His Pro
385                 390                 395                 400 
Leu Glu Ile Ala Val Phe Leu Asn Tyr Cys Thr Val Cys Asn Val Thr
                405                 410                 415     
Lys Lys Ile Phe Leu Val Ile Tyr Asn Glu Asp Thr Lys Gln Trp Val
            420                 425                 430         
Ser Gln Asp Phe Thr Leu Asp Ala Pro Ile Asp Ser Val Thr Met Pro
        435                 440                 445             
His Phe Thr Phe Ser Ala Leu Pro Gly Leu Leu Leu Trp Asn Lys His
    450                 455                 460                 
Ser Ile Tyr Tyr Cys Tyr His Asn Phe Thr Phe Thr Gly Ile Leu Gln
465                 470                 475                 480 
Thr Pro Ala Gly His Gly Asn Leu Ser Met Leu Ser Asn Asp Ser Ile
                485                 490                 495     
Ile His Glu Val Phe Ile Asp Tyr Tyr Gly Asp Ile Leu Val Lys Met
            500                 505                 510         
Glu Asn Asn Val Ile Phe Tyr Ser Lys Ile Asn Thr Arg Asp Ala Val
        515                 520                 525             
Lys Leu His Leu Trp Thr Asn Tyr Thr Thr Arg Ala Phe Ile Phe Leu
    530                 535                 540                 
Ser Thr Ser Gly Gln Thr Tyr Phe Leu Tyr Ala Leu Asp Asp Gly Thr
545                 550                 555                 560 
Ile Gln Ile Gln Asp Tyr Pro Leu His Leu Glu Ala Gln Ser Ile Ala
                565                 570                 575     
Phe Thr Thr Lys Asp Lys Cys Pro Tyr Met Ala Phe His Asn Asn Val
            580                 585                 590         
Ala His Val Phe Tyr Phe Leu Asp Lys Gly Glu Ala Leu Thr Val Trp
        595                 600                 605             
Thr Gln Ile Val Tyr Pro Glu Asn Thr Gly Leu Tyr Val Ile Val Glu
    610                 615                 620                 
Ser Tyr Gly Pro Lys Ile Leu Gln Glu Ser His Glu Ile Ser Phe Glu
625                 630                 635                 640 
Ala Ala Phe Gly Tyr Cys Thr Lys Thr Leu Thr Leu Thr Phe Tyr Gln
                645                 650                 655     
Asn Val Asp Tyr Glu Arg Ile Ser Asp Tyr Phe Glu Thr Gln Asp Lys
            660                 665                 670         
His Thr Gly Leu Val Leu Val Gln Phe Arg Pro Ser Glu Tyr Ser Lys
        675                 680                 685             
Ala Cys Pro Ile Ala Gln Lys Val Phe Gln Ile Ala Val Gly Cys Asp
    690                 695                 700                 
Asp Lys Lys Phe Ile Ala Ile Lys Gly Phe Ser Lys Lys Gly Cys His
705                 710                 715                 720 
His His Asp Phe Ser Tyr Val Ile Glu Lys Ser Tyr Leu Arg His Gln
                725                 730                 735     
Pro Ser Lys Asn Leu Arg Val Arg Tyr Ile Trp Gly Glu Tyr Gly Cys
            740                 745                 750         
Pro Leu Arg Leu Asp Phe Thr Glu Lys Phe Gln Pro Val Val Gln Leu
        755                 760                 765             
Phe Asp Asp Asn Gly Tyr Val Lys Asp Val Glu Ala Asn Phe Ile Val
    770                 775                 780                 
Trp Glu Ile His Gly Arg Asp Asp Tyr Ser Phe Asn Asn Thr Met Ala
785                 790                 795                 800 
Gln Ser Gly Cys Leu His Glu Ala Gln Thr Trp Lys Ser Met Ile Glu
                805                 810                 815     
Leu Asn Lys His Leu Pro Leu Glu Glu Val Trp Gly Pro Glu Phe Leu
            820                 825                 830         


<210> 8669
<211> 361
<212> PRT
<213> Homo sapiens

<400> 8669
Met Lys Gln Lys Met Met Ala Arg Leu Leu Arg Thr Ser Phe Ala Leu
 1               5                  10                  15      
Leu Phe Leu Gly Leu Phe Gly Val Leu Gly Ala Ala Thr Ile Ser Cys
            20                  25                  30          
Arg Asn Glu Glu Gly Lys Ala Val Asp Trp Phe Thr Phe Tyr Lys Leu
        35                  40                  45              
Pro Lys Arg Gln Asn Lys Glu Ser Gly Glu Thr Gly Leu Glu Tyr Leu
    50                  55                  60                  
Tyr Leu Asp Ser Thr Thr Arg Ser Trp Arg Lys Ser Glu Gln Leu Met
65                  70                  75                  80  
Asn Asp Thr Lys Ser Val Leu Gly Arg Thr Leu Gln Gln Leu Tyr Glu
                85                  90                  95      
Ala Tyr Ala Ser Lys Ser Asn Asn Thr Ala Tyr Leu Ile Tyr Asn Asp
            100                 105                 110         
Gly Val Pro Lys Pro Val Asn Tyr Ser Arg Lys Tyr Gly His Thr Lys
        115                 120                 125             
Gly Leu Leu Leu Trp Asn Arg Val Gln Gly Phe Trp Leu Ile His Ser
    130                 135                 140                 
Ile Pro Gln Phe Pro Pro Ile Pro Glu Glu Gly Tyr Asp Tyr Pro Pro
145                 150                 155                 160 
Thr Gly Arg Arg Asn Gly Gln Ser Gly Ile Cys Ile Thr Phe Lys Tyr
                165                 170                 175     
Asn Gln Tyr Glu Ala Ile Asp Ser Gln Leu Leu Val Cys Asn Pro Asn
            180                 185                 190         
Val Tyr Ser Cys Ser Ile Pro Ala Thr Phe His Gln Glu Leu Ile His
        195                 200                 205             
Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg
    210                 215                 220                 
Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe
225                 230                 235                 240 
Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala
                245                 250                 255     
Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg
            260                 265                 270         
Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile
        275                 280                 285             
Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp
    290                 295                 300                 
His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr
305                 310                 315                 320 
Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly
                325                 330                 335     
Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly
            340                 345                 350         
Leu Val Leu Tyr Tyr Glu Ser Cys Lys
        355                 360     


<210> 8670
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8670
Met Thr His Cys Cys Ser Pro Cys Cys Gln Pro Thr Cys Cys Arg Thr
 1               5                  10                  15      
Thr Cys Cys Arg Thr Thr Cys Trp Lys Pro Thr Thr Val Thr Thr Cys
            20                  25                  30          
Ser Ser Thr Pro Cys Cys Gln Pro Ser Cys Cys Val Ser Ser Cys Cys
        35                  40                  45              
Gln Pro Cys Cys Arg Pro Ala Cys Cys Gln Asn Thr Cys Cys Arg Thr
    50                  55                  60                  
Thr Cys Cys Gln Pro Thr Cys Leu Ser Ser Cys Cys Gly Gln Thr Ser
65                  70                  75                  80  
Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser Cys Ala Pro Val Tyr Cys
                85                  90                  95      
Arg Arg Thr Cys Tyr Tyr Pro Thr Thr Val Cys Leu Pro Gly Cys Leu
            100                 105                 110         
Asn Gln Ser Cys Gly Ser Ser Cys Cys Gln Pro Cys Cys Arg Pro Ala
        115                 120                 125             
Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr Cys Phe Gln Pro Thr Cys
    130                 135                 140                 
Val Ser Ser Cys Cys Gln Pro Ser Cys Cys
145                 150                 


<210> 8671
<211> 111
<212> PRT
<213> Homo sapiens

<400> 8671
Thr Thr Cys Cys Gln Pro Thr Cys Leu Thr Ser Cys Cys Gln Pro Ser
 1               5                  10                  15      
Cys Cys Ser Thr Thr Cys Cys Gln Pro Ile Cys Cys Gly Ser Ser Cys
            20                  25                  30          
Cys Gly Gln Thr Ser Cys Gly Ser Ser Cys Gly Gln Ser Ser Ser Cys
        35                  40                  45              
Ala Pro Val Tyr Cys Arg Arg Thr Cys Tyr Tyr Pro Thr Thr Val Cys
    50                  55                  60                  
Leu Pro Gly Cys Leu Asn Gln Ser Cys Gly Ser Ser Cys Cys Gln Pro
65                  70                  75                  80  
Cys Cys Arg Pro Ala Cys Cys Glu Thr Thr Cys Cys Arg Thr Thr Cys
                85                  90                  95      
Phe Gln Pro Thr Cys Val Ser Ser Cys Cys Gln Pro Ser Cys Cys
            100                 105                 110     


<210> 8672
<211> 512
<212> PRT
<213> Homo sapiens

<400> 8672
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys
 1               5                  10                  15      
Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr
            20                  25                  30          
Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg
        35                  40                  45              
Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Ala
    50                  55                  60                  
Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp
65                  70                  75                  80  
Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn
                85                  90                  95      
Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg
            100                 105                 110         
Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro
        115                 120                 125             
Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu
    130                 135                 140                 
Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr
145                 150                 155                 160 
Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro
                165                 170                 175     
Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu
            180                 185                 190         
Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln
        195                 200                 205             
Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys
    210                 215                 220                 
Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys
225                 230                 235                 240 
His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn
                245                 250                 255     
Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser
            260                 265                 270         
Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys
        275                 280                 285             
His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp
    290                 295                 300                 
Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg
305                 310                 315                 320 
Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val
                325                 330                 335     
Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro
            340                 345                 350         
Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu
        355                 360                 365             
Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile
    370                 375                 380                 
Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys
385                 390                 395                 400 
Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu
                405                 410                 415     
Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val
            420                 425                 430         
His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro
        435                 440                 445             
Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp
    450                 455                 460                 
Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu
465                 470                 475                 480 
Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu
                485                 490                 495     
Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile
            500                 505                 510         


<210> 8673
<211> 518
<212> PRT
<213> Homo sapiens

<400> 8673
Met Cys Pro Gln Glu Ser Ser Phe Gln Pro Ser Gln Phe Leu Leu Leu
 1               5                  10                  15      
Val Gly Val Pro Val Ala Ser Val Leu Leu Leu Ala Gln Cys Leu Arg
            20                  25                  30          
Trp His Cys Pro Arg Arg Leu Leu Gly Ala Cys Trp Thr Leu Asn Gly
        35                  40                  45              
Gln Glu Glu Pro Val Ser Gln Pro Thr Pro Gln Leu Glu Asn Glu Val
    50                  55                  60                  
Ser Arg Gln His Leu Pro Ala Thr Leu Pro Glu Met Val Ala Phe Tyr
65                  70                  75                  80  
Gln Glu Leu His Thr Pro Thr Gln Gly Gln Thr Met Val Arg Gln Leu
                85                  90                  95      
Met His Lys Leu Leu Val Phe Ser Ala Arg Glu Val Asp His Arg Gly
            100                 105                 110         
Gly Cys Leu Met Leu Gln Asp Thr Gly Ile Ser Leu Leu Ile Pro Pro
        115                 120                 125             
Gly Ala Val Ala Val Gly Arg Gln Glu Arg Val Ser Leu Ile Leu Val
    130                 135                 140                 
Trp Asp Leu Ser Asp Ala Pro Ser Leu Ser Gln Ala Gln Gly Leu Val
145                 150                 155                 160 
Ser Pro Val Val Ala Cys Gly Pro His Gly Ala Ser Phe Leu Lys Pro
                165                 170                 175     
Cys Thr Leu Thr Phe Lys His Cys Ala Glu Gln Pro Ser His Ala Arg
            180                 185                 190         
Thr Tyr Ser Ser Asn Thr Thr Leu Leu Asp Ala Lys Val Trp Arg Pro
        195                 200                 205             
Leu Gly Arg Pro Gly Ala His Ala Ser Arg Asp Glu Cys Arg Ile His
    210                 215                 220                 
Leu Ser His Phe Ser Leu Tyr Thr Cys Val Leu Glu Ala Pro Val Gly
225                 230                 235                 240 
Arg Glu Ala Arg Lys Trp Leu Gln Leu Ala Val Phe Cys Ser Pro Leu
                245                 250                 255     
Val Pro Gly Gln Ser His Leu Gln Leu Arg Ile Tyr Phe Leu Asn Asn
            260                 265                 270         
Thr Pro Cys Ala Leu Gln Trp Ala Leu Thr Asn Glu Gln Pro His Gly
        275                 280                 285             
Gly Arg Leu Arg Gly Pro Cys Gln Leu Phe Asp Phe Asn Gly Ala Arg
    290                 295                 300                 
Gly Asp Gln Cys Leu Lys Leu Thr Tyr Ile Ser Glu Gly Trp Glu Asn
305                 310                 315                 320 
Val Asp Asp Ser Ser Cys Gln Leu Val Pro His Leu His Ile Trp His
                325                 330                 335     
Gly Lys Cys Pro Phe Arg Ser Phe Cys Phe Arg Arg Lys Ala Ala Asp
            340                 345                 350         
Glu Asn Glu Asp Cys Ser Ala Leu Thr Asn Glu Ile Ile Val Thr Met
        355                 360                 365             
His Thr Phe Gln Asp Gly Leu Glu Thr Lys Tyr Met Glu Ile Leu Arg
    370                 375                 380                 
Phe Gln Ala Ser Glu Glu Glu Ser Trp Ala Ala Pro Pro Pro Val Ser
385                 390                 395                 400 
Gln Pro Pro Pro Cys Asn Arg Leu Pro Pro Glu Leu Phe Glu Gln Leu
                405                 410                 415     
Arg Met Leu Leu Glu Pro Asn Ser Ile Thr Gly Asn Asp Trp Arg Gly
            420                 425                 430         
Leu Ala Ser His Leu Gly Leu Cys Gly Met Lys Ile Arg Phe Leu Ser
        435                 440                 445             
Cys Gln Arg Ser Pro Ala Ala Ala Ile Leu Glu Leu Phe Glu Glu Gln
    450                 455                 460                 
Asn Gly Ser Leu Gln Glu Leu His Tyr Leu Met Thr Val Met Glu Arg
465                 470                 475                 480 
Leu Asp Cys Ala Ser Ala Ile Gln Asn Tyr Leu Ser Gly Thr His Gly
                485                 490                 495     
Gly Ser Pro Gly Pro Glu Arg Gly Gly Ala Arg Asp Asn Gln Gly Leu
            500                 505                 510         
Glu Leu Asp Glu Lys Leu
        515             


<210> 8674
<211> 616
<212> PRT
<213> Homo sapiens

<400> 8674
Arg Ala Trp Leu Leu Ala Ala Gly Ser Ala Gly Thr Gly Arg Glu Ala
 1               5                  10                  15      
Gly Gly Ser Gly Thr Trp Ile Gln Met Lys Arg Ser Lys Glu Leu Ile
            20                  25                  30          
Thr Lys Asn His Ser Gln Glu Glu Thr Ser Ile Leu Arg Cys Trp Lys
        35                  40                  45              
Cys Arg Lys Cys Ile Ala Ser Ser Gly Cys Phe Met Glu Tyr Leu Glu
    50                  55                  60                  
Asn Gln Val Ile Lys Asp Lys Asp Asp Ser Val Asp Ala Gln Asn Ile
65                  70                  75                  80  
Cys His Val Trp His Met Asn Val Glu Ala Leu Pro Glu Trp Ile Ser
                85                  90                  95      
Cys Leu Ile Gln Lys Ala Gln Trp Thr Val Gly Lys Leu Asn Cys Pro
            100                 105                 110         
Phe Cys Gly Ala Arg Leu Gly Gly Phe Asn Phe Val Ser Thr Pro Lys
        115                 120                 125             
Cys Ser Cys Gly Gln Leu Ala Ala Val His Leu Ser Lys Ser Arg Thr
    130                 135                 140                 
Asp Tyr Gln Pro Thr Gln Ala Gly Arg Leu Met Arg Pro Ser Val Lys
145                 150                 155                 160 
Tyr Leu Ser His Pro Arg Val Gln Ser Gly Cys Asp Lys Glu Ala Leu
                165                 170                 175     
Leu Thr Gly Gly Gly Ser Glu Asn Arg Asn His Arg Leu Leu Asn Met
            180                 185                 190         
Ala Arg Asn Asn Asn Asp Pro Gly Arg Leu Thr Glu Ala Leu Cys Leu
        195                 200                 205             
Glu Val Arg Pro Thr Tyr Phe Glu Met Lys Asn Glu Lys Leu Leu Ser
    210                 215                 220                 
Lys Ala Ser Glu Pro Lys Tyr Gln Leu Phe Val Pro Gln Leu Val Thr
225                 230                 235                 240 
Gly Arg Cys Ala Thr Arg Ala Phe His Arg Lys Ser His Ser Leu Asp
                245                 250                 255     
Leu Asn Ile Ser Glu Lys Leu Thr Leu Leu Pro Thr Leu Tyr Glu Ile
            260                 265                 270         
His Ser Lys Thr Thr Ala Tyr Ser Arg Leu Asn Glu Thr Gln Pro Ile
        275                 280                 285             
Asp Leu Ser Gly Leu Pro Leu Gln Ser Ser Lys Asn Ser Tyr Ser Phe
    290                 295                 300                 
Gln Asn Pro Ser Ser Phe Asp Pro Ser Met Leu Leu Gln Arg Phe Ser
305                 310                 315                 320 
Val Ala Pro His Glu Thr Gln Thr Gln Arg Gly Gly Glu Phe Gln Cys
                325                 330                 335     
Gly Leu Glu Ala Ala Ser Val Tyr Ser Asp His Thr Asn Thr Asn Asn
            340                 345                 350         
Leu Thr Phe Leu Met Asp Leu Pro Ser Ala Gly Arg Ser Met Pro Glu
        355                 360                 365             
Ala Ser Asp Gln Glu Glu His Leu Ser Pro Leu Asp Phe Leu His Ser
    370                 375                 380                 
Ala Asn Phe Ser Leu Gly Ser Ile Asn Gln Arg Leu Asn Lys Arg Glu
385                 390                 395                 400 
Arg Ser Lys Leu Lys Asn Leu Arg Arg Lys Gln Arg Arg Arg Glu Arg
                405                 410                 415     
Trp Leu Gln Lys Gln Gly Lys Tyr Ser Gly Val Gly Leu Leu Asp His
            420                 425                 430         
Met Thr Leu Asn Asn Glu Met Ser Thr Asp Glu Asp Asn Glu Tyr Ala
        435                 440                 445             
Glu Glu Lys Asp Ser Tyr Ile Cys Ala Val Cys Leu Asp Val Tyr Phe
    450                 455                 460                 
Asn Pro Tyr Met Cys Tyr Pro Cys His His Ile Phe Cys Glu Pro Cys
465                 470                 475                 480 
Leu Arg Thr Leu Ala Lys Asp Asn Pro Ser Ser Thr Pro Cys Pro Leu
                485                 490                 495     
Cys Arg Thr Ile Ile Ser Arg Val Phe Phe Gln Thr Glu Leu Asn Asn
            500                 505                 510         
Ala Thr Lys Thr Phe Phe Thr Lys Glu Tyr Leu Lys Ile Lys Gln Ser
        515                 520                 525             
Phe Gln Lys Ser Asn Ser Ala Lys Trp Pro Leu Pro Ser Cys Arg Lys
    530                 535                 540                 
Ala Phe His Leu Phe Gly Gly Phe Arg Arg His Ala Ala Pro Val Thr
545                 550                 555                 560 
Arg Arg Gln Phe Pro His Gly Ala His Arg Met Asp Tyr Leu His Phe
                565                 570                 575     
Glu Asp Asp Ser Arg Gly Trp Trp Phe Asp Met Asp Met Val Ile Ile
            580                 585                 590         
Tyr Ile Tyr Ser Val Asn Trp Val Ile Gly Phe Ile Val Phe Cys Phe
        595                 600                 605             
Leu Cys Tyr Phe Phe Phe Pro Phe
    610                 615     


<210> 8675
<211> 592
<212> PRT
<213> Homo sapiens

<400> 8675
Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser
 1               5                  10                  15      
Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala
            20                  25                  30          
Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr
        35                  40                  45              
Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala
    50                  55                  60                  
Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu
65                  70                  75                  80  
Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln
                85                  90                  95      
Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn
            100                 105                 110         
Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu
        115                 120                 125             
Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys
    130                 135                 140                 
Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala
145                 150                 155                 160 
Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met
                165                 170                 175     
Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu
            180                 185                 190         
Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val
        195                 200                 205             
Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His
    210                 215                 220                 
Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys
225                 230                 235                 240 
Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly
                245                 250                 255     
Val Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp
            260                 265                 270         
Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr
        275                 280                 285             
Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln
    290                 295                 300                 
Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His
305                 310                 315                 320 
Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr
                325                 330                 335     
Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln
            340                 345                 350         
Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn
        355                 360                 365             
Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu
    370                 375                 380                 
Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met
385                 390                 395                 400 
Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu
                405                 410                 415     
Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu
            420                 425                 430         
Pro Val Met Val Asn His Gln His Leu Pro Thr Thr Ile Pro Ala Gly
        435                 440                 445             
Ser Asn Ser Tyr Gln Pro Val Pro Ile Thr Ile Pro Lys Glu Asp Ser
    450                 455                 460                 
Gln Arg His Arg Val Thr Asp Glu Glu Val Gln Gln Ser Arg Phe Gln
465                 470                 475                 480 
Met Pro Pro Leu Glu Glu Gly Leu Glu Glu Leu His Ala Ser His Ile
                485                 490                 495     
Pro Thr Ala Asn Pro Gly His Cys Ile Thr Asp Pro Pro Ser Leu Gly
            500                 505                 510         
Pro Gln Tyr His Pro Arg Ser Asn Ser Glu Ser Ser Thr Ser Ser Gly
        515                 520                 525             
Glu Asp Tyr Cys Asn Ser Pro Lys Ser Lys Leu Pro Pro Trp Asn Pro
    530                 535                 540                 
Gln Val Phe Ser Ser Glu Arg Ser Ser Phe Leu Glu Gln Pro Pro Asn
545                 550                 555                 560 
Leu Glu Leu Ala Gly Thr Gln Pro Ala Phe Ser Gly Ser Pro Ser Pro
                565                 570                 575     
Gln Pro Asp Ser Thr Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala
            580                 585                 590         


<210> 8676
<211> 668
<212> PRT
<213> Homo sapiens

<400> 8676
Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser
 1               5                  10                  15      
Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala
            20                  25                  30          
Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr
        35                  40                  45              
Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala
    50                  55                  60                  
Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu
65                  70                  75                  80  
Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln
                85                  90                  95      
Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn
            100                 105                 110         
Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu
        115                 120                 125             
Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys
    130                 135                 140                 
Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala
145                 150                 155                 160 
Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met
                165                 170                 175     
Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu
            180                 185                 190         
Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val
        195                 200                 205             
Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His
    210                 215                 220                 
Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys
225                 230                 235                 240 
Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly
                245                 250                 255     
Val Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp
            260                 265                 270         
Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr
        275                 280                 285             
Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln
    290                 295                 300                 
Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His
305                 310                 315                 320 
Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr
                325                 330                 335     
Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln
            340                 345                 350         
Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn
        355                 360                 365             
Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu
    370                 375                 380                 
Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met
385                 390                 395                 400 
Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu
                405                 410                 415     
Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu
            420                 425                 430         
Pro Val Met Val Asn His Gln His Leu Pro Thr Thr Ile Pro Ala Gly
        435                 440                 445             
Ser Asn Ser Tyr Gln Pro Val Pro Ile Thr Ile Pro Lys Glu Val Phe
    450                 455                 460                 
Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser
465                 470                 475                 480 
Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro
                485                 490                 495     
Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp
            500                 505                 510         
Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly
        515                 520                 525             
Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His
    530                 535                 540                 
Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser
545                 550                 555                 560 
Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro
                565                 570                 575     
Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg
            580                 585                 590         
Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln
        595                 600                 605             
Pro Ala Phe Ser Ala Gly Pro Pro Ala Asp Asp Ser Ser Ser Thr Ser
    610                 615                 620                 
Ser Gly Glu Trp Tyr Gln Asn Phe Gln Pro Pro Pro Gln Pro Pro Ser
625                 630                 635                 640 
Glu Glu Gln Phe Gly Cys Pro Gly Ser Pro Ser Pro Gln Pro Asp Ser
                645                 650                 655     
Thr Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala
            660                 665             


<210> 8677
<211> 601
<212> PRT
<213> Homo sapiens

<400> 8677
Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser
 1               5                  10                  15      
Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala
            20                  25                  30          
Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr
        35                  40                  45              
Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala
    50                  55                  60                  
Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu
65                  70                  75                  80  
Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln
                85                  90                  95      
Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn
            100                 105                 110         
Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu
        115                 120                 125             
Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys
    130                 135                 140                 
Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala
145                 150                 155                 160 
Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met
                165                 170                 175     
Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu
            180                 185                 190         
Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val
        195                 200                 205             
Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His
    210                 215                 220                 
Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys
225                 230                 235                 240 
Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly
                245                 250                 255     
Val Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp
            260                 265                 270         
Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr
        275                 280                 285             
Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln
    290                 295                 300                 
Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His
305                 310                 315                 320 
Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr
                325                 330                 335     
Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln
            340                 345                 350         
Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn
        355                 360                 365             
Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu
    370                 375                 380                 
Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met
385                 390                 395                 400 
Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu
                405                 410                 415     
Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe
            420                 425                 430         
Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser
        435                 440                 445             
Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro
    450                 455                 460                 
Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp
465                 470                 475                 480 
Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly
                485                 490                 495     
Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His
            500                 505                 510         
Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser
        515                 520                 525             
Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro
    530                 535                 540                 
Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg
545                 550                 555                 560 
Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln
                565                 570                 575     
Pro Ala Phe Ser Gly Ser Pro Ser Pro Gln Pro Asp Ser Thr Asp Asn
            580                 585                 590         
Asp Asp Tyr Asp Asp Ile Ser Ala Ala
        595                 600     


<210> 8678
<211> 636
<212> PRT
<213> Homo sapiens

<400> 8678
Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser
 1               5                  10                  15      
Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala
            20                  25                  30          
Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr
        35                  40                  45              
Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala
    50                  55                  60                  
Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu
65                  70                  75                  80  
Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln
                85                  90                  95      
Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn
            100                 105                 110         
Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu
        115                 120                 125             
Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys
    130                 135                 140                 
Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala
145                 150                 155                 160 
Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met
                165                 170                 175     
Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu
            180                 185                 190         
Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val
        195                 200                 205             
Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His
    210                 215                 220                 
Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys
225                 230                 235                 240 
Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly
                245                 250                 255     
Val Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp
            260                 265                 270         
Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr
        275                 280                 285             
Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln
    290                 295                 300                 
Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His
305                 310                 315                 320 
Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr
                325                 330                 335     
Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln
            340                 345                 350         
Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn
        355                 360                 365             
Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu
    370                 375                 380                 
Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met
385                 390                 395                 400 
Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu
                405                 410                 415     
Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe
            420                 425                 430         
Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser
        435                 440                 445             
Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro
    450                 455                 460                 
Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp
465                 470                 475                 480 
Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly
                485                 490                 495     
Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His
            500                 505                 510         
Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser
        515                 520                 525             
Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro
    530                 535                 540                 
Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg
545                 550                 555                 560 
Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln
                565                 570                 575     
Pro Ala Phe Ser Ala Gly Pro Pro Ala Asp Asp Ser Ser Ser Thr Ser
            580                 585                 590         
Ser Gly Glu Trp Tyr Gln Asn Phe Gln Pro Pro Pro Gln Pro Pro Ser
        595                 600                 605             
Glu Glu Gln Phe Gly Cys Pro Gly Ser Pro Ser Pro Gln Pro Asp Ser
    610                 615                 620                 
Thr Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala
625                 630                 635     


<210> 8679
<211> 595
<212> PRT
<213> Homo sapiens

<400> 8679
Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser
 1               5                  10                  15      
Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala
            20                  25                  30          
Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr
        35                  40                  45              
Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala
    50                  55                  60                  
Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu
65                  70                  75                  80  
Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln
                85                  90                  95      
Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn
            100                 105                 110         
Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu
        115                 120                 125             
Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys
    130                 135                 140                 
Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala
145                 150                 155                 160 
Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met
                165                 170                 175     
Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu
            180                 185                 190         
Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val
        195                 200                 205             
Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His
    210                 215                 220                 
Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys
225                 230                 235                 240 
Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly
                245                 250                 255     
Val Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp
            260                 265                 270         
Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr
        275                 280                 285             
Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln
    290                 295                 300                 
Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His
305                 310                 315                 320 
Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr
                325                 330                 335     
Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln
            340                 345                 350         
Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn
        355                 360                 365             
Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu
    370                 375                 380                 
Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met
385                 390                 395                 400 
Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu
                405                 410                 415     
Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Asp Ser
            420                 425                 430         
Gln Arg His Arg Val Thr Asp Glu Glu Val Gln Gln Ser Arg Phe Gln
        435                 440                 445             
Met Pro Pro Leu Glu Glu Gly Leu Glu Glu Leu His Ala Ser His Ile
    450                 455                 460                 
Pro Thr Ala Asn Pro Gly His Cys Ile Thr Asp Pro Pro Ser Leu Gly
465                 470                 475                 480 
Pro Gln Tyr His Pro Arg Ser Asn Ser Glu Ser Ser Thr Ser Ser Gly
                485                 490                 495     
Glu Asp Tyr Cys Asn Ser Pro Lys Ser Lys Leu Pro Pro Trp Asn Pro
            500                 505                 510         
Gln Val Phe Ser Ser Glu Arg Ser Ser Phe Leu Glu Gln Pro Pro Asn
        515                 520                 525             
Leu Glu Leu Ala Gly Thr Gln Pro Ala Phe Ser Ala Gly Pro Pro Ala
    530                 535                 540                 
Asp Asp Ser Ser Ser Thr Ser Ser Gly Glu Trp Tyr Gln Asn Phe Gln
545                 550                 555                 560 
Pro Pro Pro Gln Pro Pro Ser Glu Glu Gln Phe Gly Cys Pro Gly Ser
                565                 570                 575     
Pro Ser Pro Gln Pro Asp Ser Thr Asp Asn Asp Asp Tyr Asp Asp Ile
            580                 585                 590         
Ser Ala Ala
        595 


<210> 8680
<211> 788
<212> PRT
<213> Homo sapiens

<400> 8680
Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn
 1               5                  10                  15      
Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu
            20                  25                  30          
Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn
        35                  40                  45              
Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn
    50                  55                  60                  
Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser
65                  70                  75                  80  
Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys
                85                  90                  95      
Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys
            100                 105                 110         
Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr
        115                 120                 125             
Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser
    130                 135                 140                 
Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser
145                 150                 155                 160 
Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser
                165                 170                 175     
Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu
            180                 185                 190         
Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe
        195                 200                 205             
Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn
    210                 215                 220                 
Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu
225                 230                 235                 240 
Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile
                245                 250                 255     
Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala
            260                 265                 270         
Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro
        275                 280                 285             
Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser
    290                 295                 300                 
Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val
305                 310                 315                 320 
Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His
                325                 330                 335     
Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu
            340                 345                 350         
Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr
        355                 360                 365             
Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu
    370                 375                 380                 
Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe
385                 390                 395                 400 
Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser
                405                 410                 415     
Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His
            420                 425                 430         
Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val
        435                 440                 445             
Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser
    450                 455                 460                 
Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala
465                 470                 475                 480 
Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met
                485                 490                 495     
Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser
            500                 505                 510         
Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro
        515                 520                 525             
Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys
    530                 535                 540                 
Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys
545                 550                 555                 560 
Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys
                565                 570                 575     
Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser
            580                 585                 590         
Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly
        595                 600                 605             
Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys
    610                 615                 620                 
Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln
625                 630                 635                 640 
Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile
                645                 650                 655     
Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu
            660                 665                 670         
Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn
        675                 680                 685             
Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys
    690                 695                 700                 
Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu
705                 710                 715                 720 
Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe
                725                 730                 735     
His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala
            740                 745                 750         
Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr
        755                 760                 765             
Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu
    770                 775                 780                 
Ser Thr Asp Cys
785             


<210> 8681
<211> 429
<212> PRT
<213> Homo sapiens

<400> 8681
Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro
 1               5                  10                  15      
Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser
            20                  25                  30          
Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala
        35                  40                  45              
Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly
    50                  55                  60                  
Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp
65                  70                  75                  80  
Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu
                85                  90                  95      
Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp
            100                 105                 110         
Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp
        115                 120                 125             
Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr
    130                 135                 140                 
Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr
145                 150                 155                 160 
Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser
                165                 170                 175     
Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser
            180                 185                 190         
Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro
        195                 200                 205             
Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val
    210                 215                 220                 
Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr
225                 230                 235                 240 
Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser
                245                 250                 255     
Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly
            260                 265                 270         
Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu
        275                 280                 285             
Ala Val Thr Leu Asn Phe Thr Val Pro Thr Gly Ala Arg Ser Asn His
    290                 295                 300                 
Leu Thr Ser Gly Val Ile Glu Gly Leu Leu Ser Thr Leu Gly Pro Ala
305                 310                 315                 320 
Thr Val Ala Leu Leu Phe Cys Tyr Gly Leu Lys Arg Lys Ile Gly Arg
                325                 330                 335     
Arg Ser Ala Arg Asp Pro Leu Arg Ser Leu Pro Ser Pro Leu Pro Gln
            340                 345                 350         
Glu Phe Thr Tyr Leu Asn Ser Pro Thr Pro Gly Gln Leu Gln Pro Ile
        355                 360                 365             
Tyr Glu Asn Val Asn Val Val Ser Gly Asp Glu Val Tyr Ser Leu Ala
    370                 375                 380                 
Tyr Tyr Asn Gln Pro Glu Gln Glu Ser Val Ala Ala Glu Thr Leu Gly
385                 390                 395                 400 
Thr His Met Glu Asp Lys Val Ser Leu Asp Ile Tyr Ser Arg Leu Arg
                405                 410                 415     
Lys Ala Asn Ile Thr Asp Val Asp Tyr Glu Asp Ala Met
            420                 425                 


<210> 8682
<211> 366
<212> PRT
<213> Homo sapiens

<400> 8682
Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro
 1               5                  10                  15      
Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser
            20                  25                  30          
Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala
        35                  40                  45              
Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly
    50                  55                  60                  
Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp
65                  70                  75                  80  
Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu
                85                  90                  95      
Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp
            100                 105                 110         
Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp
        115                 120                 125             
Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr
    130                 135                 140                 
Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr
145                 150                 155                 160 
Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser
                165                 170                 175     
Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser
            180                 185                 190         
Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro
        195                 200                 205             
Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val
    210                 215                 220                 
Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr
225                 230                 235                 240 
Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser
                245                 250                 255     
Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly
            260                 265                 270         
Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu
        275                 280                 285             
Ala Val Thr Leu Asn Phe Thr Gly Arg Arg Ser Ala Arg Asp Pro Leu
    290                 295                 300                 
Arg Ser Leu Pro Ser Pro Leu Pro Gln Glu Phe Thr Tyr Leu Asn Ser
305                 310                 315                 320 
Pro Thr Pro Gly Gln Leu Gln Pro Ile Tyr Glu Asn Glu Pro Arg Glu
                325                 330                 335     
Gln Ser Val Ala Val His Gly Arg Gln Gln His Ser Ser Glu Gln Lys
            340                 345                 350         
Ala Gln Lys Pro Trp Gly His Ile Trp Arg Thr Arg Phe Pro
        355                 360                 365     


<210> 8683
<211> 188
<212> PRT
<213> Homo sapiens

<400> 8683
Met Val Pro Gly Ala Ala Gly Trp Cys Cys Leu Val Leu Trp Leu Pro
 1               5                  10                  15      
Ala Cys Val Ala Ala His Gly Phe Arg Ile His Asp Tyr Leu Tyr Phe
            20                  25                  30          
Gln Val Leu Ser Pro Gly Asp Ile Arg Tyr Ile Phe Thr Ala Thr Pro
        35                  40                  45              
Ala Lys Asp Phe Gly Gly Ile Phe His Thr Arg Tyr Glu Gln Ile His
    50                  55                  60                  
Leu Val Pro Ala Glu Pro Pro Glu Ala Cys Gly Glu Leu Ser Asn Gly
65                  70                  75                  80  
Phe Phe Ile Gln Asp Gln Ile Ala Leu Val Glu Arg Gly Gly Cys Ser
                85                  90                  95      
Phe Leu Ser Lys Thr Arg Val Val Gln Glu His Gly Gly Arg Ala Val
            100                 105                 110         
Ile Ile Ser Asp Asn Ala Val Asp Asn Asp Ser Phe Tyr Val Glu Met
        115                 120                 125             
Ile Gln Asp Ser Thr Gln Arg Thr Ala Asp Ile Pro Ala Leu Phe Leu
    130                 135                 140                 
Leu Gly Arg Asp Gly Tyr Met Ile Arg Arg Ser Leu Glu Gln His Gly
145                 150                 155                 160 
Leu Pro Trp Ala Ile Ile Ser Ile Pro Val Asn Val Thr Ser Ile Pro
                165                 170                 175     
Thr Phe Glu Leu Leu Gln Pro Pro Trp Thr Phe Trp
            180                 185             


<210> 8684
<211> 513
<212> PRT
<213> Homo sapiens

<400> 8684
Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly
 1               5                  10                  15      
Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro
            20                  25                  30          
Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly
        35                  40                  45              
Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser
    50                  55                  60                  
Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln
65                  70                  75                  80  
Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu
                85                  90                  95      
His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu
            100                 105                 110         
Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg
        115                 120                 125             
Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser
    130                 135                 140                 
Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser
145                 150                 155                 160 
Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro
                165                 170                 175     
Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser
            180                 185                 190         
Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe
        195                 200                 205             
Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr
    210                 215                 220                 
Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe
225                 230                 235                 240 
Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe
                245                 250                 255     
Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe
            260                 265                 270         
Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser
        275                 280                 285             
Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly
    290                 295                 300                 
Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr
305                 310                 315                 320 
Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly
                325                 330                 335     
Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro
            340                 345                 350         
Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val
        355                 360                 365             
His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser
    370                 375                 380                 
Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala
385                 390                 395                 400 
Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu
                405                 410                 415     
Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala
            420                 425                 430         
Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro
        435                 440                 445             
Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu
    450                 455                 460                 
Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro
465                 470                 475                 480 
Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn
                485                 490                 495     
Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys
            500                 505                 510         
His
    


<210> 8685
<211> 336
<212> PRT
<213> Homo sapiens

<400> 8685
Met Ala Val Ala Thr Ala Ala Ala Val Leu Ala Ala Leu Gly Gly Ala
 1               5                  10                  15      
Leu Trp Leu Ala Ala Arg Arg Phe Val Gly Pro Arg Val Gln Arg Leu
            20                  25                  30          
Arg Arg Gly Gly Asp Pro Gly Leu Met His Gly Lys Thr Val Leu Ile
        35                  40                  45              
Thr Gly Ala Asn Ser Gly Leu Gly Arg Ala Thr Ala Ala Glu Leu Leu
    50                  55                  60                  
Arg Leu Gly Ala Arg Val Ile Met Gly Cys Arg Asp Arg Ala Arg Ala
65                  70                  75                  80  
Glu Glu Ala Ala Gly Gln Leu Arg Arg Glu Leu Arg Gln Ala Ala Glu
                85                  90                  95      
Cys Gly Pro Glu Pro Gly Val Ser Gly Val Gly Glu Leu Ile Val Arg
            100                 105                 110         
Glu Leu Asp Leu Ala Ser Leu Arg Ser Val Arg Ala Phe Cys Gln Glu
        115                 120                 125             
Met Leu Gln Glu Glu Pro Arg Leu Asp Val Leu Ile Asn Asn Ala Gly
    130                 135                 140                 
Ile Phe Gln Cys Pro Tyr Met Lys Thr Glu Asp Gly Phe Glu Met Gln
145                 150                 155                 160 
Phe Gly Val Asn His Leu Gly His Phe Leu Leu Thr Asn Leu Leu Leu
                165                 170                 175     
Gly Leu Leu Lys Ser Ser Ala Pro Ser Arg Ile Val Val Val Ser Ser
            180                 185                 190         
Lys Leu Tyr Lys Tyr Gly Asp Ile Asn Phe Asp Asp Leu Asn Ser Glu
        195                 200                 205             
Gln Ser Tyr Asn Lys Ser Phe Cys Tyr Ser Arg Ser Lys Leu Ala Asn
    210                 215                 220                 
Ile Leu Phe Thr Arg Glu Leu Ala Arg Arg Leu Glu Gly Thr Asn Val
225                 230                 235                 240 
Thr Val Asn Val Leu His Pro Gly Ile Val Arg Thr Asn Leu Gly Arg
                245                 250                 255     
His Ile His Ile Pro Leu Leu Val Lys Pro Leu Phe Asn Leu Val Ser
            260                 265                 270         
Trp Ala Phe Phe Lys Thr Pro Val Glu Gly Ala Gln Thr Ser Ile Tyr
        275                 280                 285             
Leu Ala Ser Ser Pro Glu Val Glu Gly Val Ser Gly Arg Tyr Phe Gly
    290                 295                 300                 
Asp Cys Lys Glu Glu Glu Leu Leu Pro Lys Ala Met Asp Glu Ser Val
305                 310                 315                 320 
Ala Arg Lys Leu Trp Asp Ile Ser Glu Val Met Val Gly Leu Leu Lys
                325                 330                 335     


<210> 8686
<211> 599
<212> PRT
<213> Homo sapiens

<400> 8686
Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg
 1               5                  10                  15      
Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp
            20                  25                  30          
Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu
        35                  40                  45              
Pro Glu Pro Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro
    50                  55                  60                  
Lys Gln Val Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser
65                  70                  75                  80  
Asp Val Gln Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp
                85                  90                  95      
Ile Arg Lys Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His
            100                 105                 110         
Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro
        115                 120                 125             
Lys Met Ile Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile
    130                 135                 140                 
Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser
145                 150                 155                 160 
His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro
                165                 170                 175     
Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr
            180                 185                 190         
Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val
        195                 200                 205             
Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr
    210                 215                 220                 
Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val
225                 230                 235                 240 
Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro
                245                 250                 255     
Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser
            260                 265                 270         
Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys
        275                 280                 285             
Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu
    290                 295                 300                 
Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn
305                 310                 315                 320 
Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val
                325                 330                 335     
Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu
            340                 345                 350         
Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile
        355                 360                 365             
Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His
    370                 375                 380                 
Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln
385                 390                 395                 400 
Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys
                405                 410                 415     
Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His
            420                 425                 430         
Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr
        435                 440                 445             
Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala
    450                 455                 460                 
Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile
465                 470                 475                 480 
Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala
                485                 490                 495     
Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile
            500                 505                 510         
Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys
        515                 520                 525             
Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser
    530                 535                 540                 
Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro
545                 550                 555                 560 
Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser
                565                 570                 575     
Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg
            580                 585                 590         
Ser Ser Gln Pro Lys Glu Trp
        595                 


<210> 8687
<211> 482
<212> PRT
<213> Homo sapiens

<400> 8687
Met Ala Glu Ala Ala Thr Pro Gly Thr Thr Ala Thr Thr Ser Gly Ala
 1               5                  10                  15      
Gly Ala Ala Ala Ala Thr Ala Ala Ala Ala Ser Pro Thr Pro Ile Pro
            20                  25                  30          
Thr Val Thr Ala Pro Ser Leu Gly Ala Gly Gly Gly Gly Gly Gly Ser
        35                  40                  45              
Asp Gly Ser Gly Gly Gly Trp Thr Lys Gln Val Thr Cys Arg Tyr Phe
    50                  55                  60                  
Met His Gly Val Cys Lys Glu Gly Asp Asn Cys Arg Tyr Ser His Asp
65                  70                  75                  80  
Leu Ser Asp Ser Pro Tyr Ser Val Val Cys Lys Tyr Phe Gln Arg Gly
                85                  90                  95      
Tyr Cys Ile Tyr Gly Asp Arg Cys Arg Tyr Glu His Ser Lys Pro Leu
            100                 105                 110         
Lys Gln Glu Glu Ala Thr Ala Thr Glu Leu Thr Thr Lys Ser Ser Leu
        115                 120                 125             
Ala Ala Ser Ser Ser Leu Ser Ser Ile Val Gly Pro Leu Val Glu Met
    130                 135                 140                 
Asn Thr Gly Glu Ala Glu Ser Arg Asn Ser Asn Phe Ala Thr Val Gly
145                 150                 155                 160 
Ala Gly Ser Glu Asp Trp Val Asn Ala Ile Glu Phe Val Pro Gly Gln
                165                 170                 175     
Pro Tyr Cys Gly Arg Thr Ala Pro Ser Cys Thr Glu Ala Pro Leu Gln
            180                 185                 190         
Gly Ser Val Thr Lys Glu Glu Ser Glu Lys Glu Gln Thr Ala Val Glu
        195                 200                 205             
Thr Lys Lys Gln Leu Cys Pro Tyr Ala Ala Val Gly Glu Cys Arg Tyr
    210                 215                 220                 
Gly Glu Asn Cys Val Tyr Leu His Gly Asp Ser Cys Asp Met Cys Gly
225                 230                 235                 240 
Leu Gln Leu Leu His Pro Met Asp Ala Ala Gln Arg Ser Gln His Ile
                245                 250                 255     
Lys Ser Cys Ile Glu Ala His Glu Lys Asp Met Glu Leu Ser Phe Ala
            260                 265                 270         
Val Gln Arg Ser Lys Asp Met Val Cys Gly Ile Cys Met Glu Val Val
        275                 280                 285             
Tyr Glu Lys Ala Asn Pro Ser Glu Arg Arg Phe Gly Ile Leu Ser Asn
    290                 295                 300                 
Cys Asn His Thr Tyr Cys Leu Lys Cys Ile Arg Lys Trp Arg Ser Ala
305                 310                 315                 320 
Lys Gln Phe Glu Ser Lys Ile Ile Lys Ser Cys Pro Glu Cys Arg Ile
                325                 330                 335     
Thr Ser Asn Phe Val Ile Pro Ser Glu Tyr Trp Val Glu Glu Lys Glu
            340                 345                 350         
Glu Lys Gln Lys Leu Ile Leu Lys Tyr Lys Glu Ala Met Ser Asn Lys
        355                 360                 365             
Ala Cys Arg Tyr Phe Asp Glu Gly Arg Gly Ser Cys Pro Phe Gly Gly
    370                 375                 380                 
Asn Cys Phe Tyr Lys His Ala Tyr Pro Asp Gly Arg Arg Glu Glu Pro
385                 390                 395                 400 
Gln Arg Gln Lys Val Gly Thr Ser Ser Arg Tyr Arg Ala Gln Arg Arg
                405                 410                 415     
Asn His Phe Trp Glu Leu Ile Glu Glu Arg Glu Asn Ser Asn Pro Phe
            420                 425                 430         
Asp Asn Asp Glu Glu Glu Val Val Thr Phe Glu Leu Gly Glu Met Leu
        435                 440                 445             
Leu Met Leu Leu Ala Ala Gly Gly Asp Asp Glu Leu Thr Asp Ser Glu
    450                 455                 460                 
Asp Glu Trp Asp Leu Phe His Asp Glu Leu Glu Asp Phe Tyr Asp Leu
465                 470                 475                 480 
Asp Leu
        


<210> 8688
<211> 380
<212> PRT
<213> Homo sapiens

<400> 8688
Met Leu Leu Tyr Glu His Ser Lys Pro Leu Lys Gln Glu Glu Ala Thr
 1               5                  10                  15      
Ala Thr Glu Leu Thr Thr Lys Ser Ser Leu Ala Ala Ser Ser Ser Leu
            20                  25                  30          
Ser Ser Ile Val Gly Pro Leu Val Glu Met Asn Thr Gly Glu Ala Glu
        35                  40                  45              
Ser Arg Asn Ser Asn Phe Ala Thr Val Gly Ala Gly Ser Glu Asp Trp
    50                  55                  60                  
Val Asn Ala Ile Glu Phe Val Pro Gly Gln Pro Tyr Cys Gly Arg Thr
65                  70                  75                  80  
Ala Pro Ser Cys Thr Glu Ala Pro Leu Gln Gly Ser Val Thr Lys Glu
                85                  90                  95      
Glu Ser Glu Lys Glu Gln Thr Ala Val Glu Thr Lys Lys Gln Leu Cys
            100                 105                 110         
Pro Tyr Ala Ala Val Gly Glu Cys Arg Tyr Gly Glu Asn Cys Val Tyr
        115                 120                 125             
Leu His Gly Asp Ser Cys Asp Met Cys Gly Leu Gln Val Leu His Pro
    130                 135                 140                 
Met Asp Ala Ala Gln Arg Ser Gln His Ile Lys Ser Cys Ile Glu Ala
145                 150                 155                 160 
His Glu Lys Asp Met Glu Leu Ser Phe Ala Val Gln Arg Ser Lys Asp
                165                 170                 175     
Met Val Cys Gly Ile Cys Met Glu Val Val Tyr Glu Lys Ala Asn Pro
            180                 185                 190         
Ser Glu Arg Arg Phe Gly Ile Leu Ser Asn Cys Asn His Thr Tyr Cys
        195                 200                 205             
Leu Lys Cys Ile Arg Lys Trp Arg Ser Ala Lys Gln Phe Glu Ser Lys
    210                 215                 220                 
Ile Ile Lys Ser Cys Pro Glu Cys Arg Ile Thr Ser Asn Phe Val Ile
225                 230                 235                 240 
Pro Ser Glu Tyr Trp Val Glu Glu Lys Glu Glu Lys Gln Lys Leu Ile
                245                 250                 255     
Leu Lys Tyr Lys Glu Ala Met Ser Asn Lys Ala Cys Arg Tyr Phe Asp
            260                 265                 270         
Glu Gly Arg Gly Ser Cys Pro Phe Gly Gly Asn Cys Phe Tyr Lys His
        275                 280                 285             
Ala Tyr Pro Asp Gly Arg Arg Glu Glu Pro Gln Arg Gln Lys Val Gly
    290                 295                 300                 
Thr Ser Ser Arg Tyr Arg Ala Gln Arg Arg Asn His Phe Trp Glu Leu
305                 310                 315                 320 
Ile Glu Glu Arg Glu Asn Ser Asn Pro Phe Asp Asn Asp Glu Glu Glu
                325                 330                 335     
Val Val Thr Phe Glu Leu Gly Glu Met Leu Leu Met Leu Leu Ala Ala
            340                 345                 350         
Gly Gly Asp Asp Glu Leu Thr Asp Ser Glu Asp Glu Trp Asp Leu Phe
        355                 360                 365             
His Asp Glu Leu Glu Asp Phe Tyr Asp Leu Asp Leu
    370                 375                 380 


<210> 8689
<211> 298
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 67
<223> Xaa = Any Amino Acid

<400> 8689
Met Phe Ser His Ala Gly Ile Thr Gly Leu Leu Ala Trp Thr Leu Gln
 1               5                  10                  15      
Pro Gln Trp Ile Gln Val Arg Asn Thr Ala Thr Ser Lys Asp Val Thr
            20                  25                  30          
Lys Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Thr Lys Ser Met
        35                  40                  45              
Gln Met Val Ala Ala Ala Lys Tyr Ala Gln Ala Glu Arg Glu Leu Lys
    50                  55                  60                  
Pro Ala Xaa Ile Tyr Gly Leu Gly Ser Leu Ala Leu Glu Lys Lys Ala
65                  70                  75                  80  
Gly Ile Lys Val Pro Glu Asp Asn Lys Lys His Leu Leu Ile Gly Val
                85                  90                  95      
Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys
            100                 105                 110         
Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val
        115                 120                 125             
Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Val Leu Tyr Arg Met
    130                 135                 140                 
His Ser Asp Gln Phe Leu Val Ala Leu Lys Glu Val Arg Arg Asn Pro
145                 150                 155                 160 
Pro Ala Phe Gly Asn Val Ser Val Ile Ala Leu Glu Leu Leu Asn Ser
                165                 170                 175     
Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Gln Phe Lys Ser
            180                 185                 190         
Val Ile Ser Tyr Lys Thr Glu Glu Lys Pro Ile Phe Phe Leu Asn Thr
        195                 200                 205             
Ile Ala Ser Ala Glu Ser Met Ser Ile Tyr Tyr Asn Ile Asp Ala Glu
    210                 215                 220                 
Val Leu Gln Asn Tyr Gln Glu Tyr Ser Leu Ala Asn Ser Ile Tyr Tyr
225                 230                 235                 240 
Ser Leu Lys Glu Ser Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala
                245                 250                 255     
Met Asp Asn Thr Ser Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr
            260                 265                 270         
Leu Thr Phe Asn Cys Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Thr
        275                 280                 285             
Glu Ile Ile Phe Gly Ala Val Ala Leu Asp
    290                 295             


<210> 8690
<211> 1094
<212> PRT
<213> Homo sapiens

<400> 8690
Met Ala Arg Pro Val Arg Gly Gly Leu Gly Ala Pro Arg Arg Ser Pro
 1               5                  10                  15      
Cys Leu Leu Leu Leu Trp Leu Leu Leu Leu Arg Leu Glu Pro Val Thr
            20                  25                  30          
Ala Ala Ala Gly Pro Arg Ala Pro Cys Ala Ala Ala Cys Thr Cys Ala
        35                  40                  45              
Gly Asp Ser Leu Asp Cys Gly Gly Arg Gly Leu Ala Ala Leu Pro Gly
    50                  55                  60                  
Asp Leu Pro Ser Trp Thr Arg Ser Leu Asn Leu Ser Tyr Asn Lys Leu
65                  70                  75                  80  
Ser Glu Ile Asp Pro Ala Gly Phe Glu Asp Leu Pro Asn Leu Gln Glu
                85                  90                  95      
Val Tyr Leu Asn Asn Asn Glu Leu Thr Ala Val Pro Ser Leu Gly Ala
            100                 105                 110         
Ala Ser Ser His Val Val Ser Leu Phe Leu Gln His Asn Lys Ile Arg
        115                 120                 125             
Ser Val Glu Gly Ser Gln Leu Lys Ala Tyr Leu Ser Leu Glu Val Leu
    130                 135                 140                 
Asp Leu Ser Leu Asn Asn Ile Thr Glu Val Arg Asn Thr Cys Phe Pro
145                 150                 155                 160 
His Gly Pro Pro Ile Lys Glu Leu Asn Leu Ala Gly Asn Arg Ile Gly
                165                 170                 175     
Thr Leu Glu Leu Gly Ala Phe Asp Gly Leu Ser Arg Ser Leu Leu Thr
            180                 185                 190         
Leu Arg Leu Ser Lys Asn Arg Ile Thr Gln Leu Pro Val Arg Ala Phe
        195                 200                 205             
Lys Leu Pro Arg Leu Thr Gln Leu Asp Leu Asn Arg Asn Arg Ile Arg
    210                 215                 220                 
Leu Ile Glu Gly Leu Thr Phe Gln Gly Leu Asn Ser Leu Glu Val Leu
225                 230                 235                 240 
Lys Leu Gln Arg Asn Asn Ile Ser Lys Leu Thr Asp Gly Ala Phe Trp
                245                 250                 255     
Gly Leu Ser Lys Met His Val Leu His Leu Glu Tyr Asn Ser Leu Val
            260                 265                 270         
Glu Val Asn Ser Gly Ser Leu Tyr Gly Leu Thr Ala Leu His Gln Leu
        275                 280                 285             
His Leu Ser Asn Asn Ser Ile Ala Arg Ile His Arg Lys Gly Trp Ser
    290                 295                 300                 
Phe Cys Gln Lys Leu His Glu Leu Val Leu Ser Phe Asn Asn Leu Thr
305                 310                 315                 320 
Arg Leu Asp Glu Glu Ser Leu Ala Glu Leu Ser Ser Leu Ser Val Leu
                325                 330                 335     
Arg Leu Ser His Asn Ser Ile Ser His Ile Ala Glu Gly Ala Phe Lys
            340                 345                 350         
Gly Leu Arg Ser Leu Arg Val Leu Asp Leu Asp His Asn Glu Ile Ser
        355                 360                 365             
Gly Thr Ile Glu Asp Thr Ser Gly Ala Phe Ser Gly Leu Asp Ser Leu
    370                 375                 380                 
Ser Lys Leu Thr Leu Phe Gly Asn Lys Ile Lys Ser Val Ala Lys Arg
385                 390                 395                 400 
Ala Phe Ser Gly Leu Glu Gly Leu Glu His Leu Asn Leu Gly Gly Asn
                405                 410                 415     
Ala Ile Arg Ser Val Gln Phe Asp Ala Phe Val Lys Met Lys Asn Leu
            420                 425                 430         
Lys Glu Leu His Ile Ser Ser Asp Ser Phe Leu Cys Asp Cys Gln Leu
        435                 440                 445             
Lys Trp Leu Pro Pro Trp Leu Ile Gly Arg Met Leu Gln Ala Phe Val
    450                 455                 460                 
Thr Ala Thr Cys Ala His Pro Glu Ser Leu Lys Gly Gln Ser Ile Phe
465                 470                 475                 480 
Ser Val Pro Pro Glu Ser Phe Val Cys Asp Asp Phe Leu Lys Pro Gln
                485                 490                 495     
Ile Ile Thr Gln Pro Glu Thr Thr Met Ala Met Val Gly Lys Asp Ile
            500                 505                 510         
Arg Phe Thr Cys Ser Ala Ala Ser Ser Ser Ser Ser Pro Met Thr Phe
        515                 520                 525             
Ala Trp Lys Lys Asp Asn Glu Val Leu Thr Asn Ala Asp Met Glu Asn
    530                 535                 540                 
Phe Val His Val His Ala Gln Asp Gly Glu Val Met Glu Tyr Thr Thr
545                 550                 555                 560 
Ile Leu His Leu Arg Gln Val Thr Phe Gly His Glu Gly Arg Tyr Gln
                565                 570                 575     
Cys Val Ile Thr Asn His Phe Gly Ser Thr Tyr Ser His Lys Ala Arg
            580                 585                 590         
Leu Thr Val Asn Val Leu Pro Ser Phe Thr Lys Thr Pro His Asp Ile
        595                 600                 605             
Thr Ile Arg Thr Thr Thr Met Ala Arg Leu Glu Cys Ala Ala Thr Gly
    610                 615                 620                 
His Pro Asn Pro Gln Ile Ala Trp Gln Lys Asp Gly Gly Thr Asp Phe
625                 630                 635                 640 
Pro Ala Ala Arg Glu Arg Arg Met His Val Met Pro Asp Asp Asp Val
                645                 650                 655     
Phe Phe Ile Thr Asp Val Lys Ile Asp Asp Ala Gly Val Tyr Ser Cys
            660                 665                 670         
Thr Ala Gln Asn Ser Ala Gly Ser Ile Ser Ala Asn Ala Thr Leu Thr
        675                 680                 685             
Val Leu Glu Thr Pro Ser Leu Val Val Pro Leu Glu Asp Arg Val Val
    690                 695                 700                 
Ser Val Gly Glu Thr Val Ala Leu Gln Cys Lys Ala Thr Gly Asn Pro
705                 710                 715                 720 
Pro Pro Arg Ile Thr Trp Phe Lys Gly Asp Arg Pro Leu Ser Leu Thr
                725                 730                 735     
Glu Arg His His Leu Thr Pro Asp Asn Gln Leu Leu Val Val Gln Asn
            740                 745                 750         
Val Val Ala Glu Asp Ala Gly Arg Tyr Thr Cys Glu Met Ser Asn Thr
        755                 760                 765             
Leu Gly Thr Glu Arg Ala His Ser Gln Leu Ser Val Leu Pro Ala Ala
    770                 775                 780                 
Gly Cys Arg Lys Asp Gly Thr Thr Val Gly Ile Phe Thr Ile Ala Val
785                 790                 795                 800 
Val Ser Ser Ile Val Leu Thr Ser Leu Val Trp Val Cys Ile Ile Tyr
                805                 810                 815     
Gln Thr Arg Lys Lys Ser Glu Glu Tyr Ser Val Thr Asn Thr Asp Glu
            820                 825                 830         
Thr Val Val Pro Pro Asp Val Pro Ser Tyr Leu Ser Ser Gln Gly Thr
        835                 840                 845             
Leu Ser Asp Arg Gln Glu Thr Val Val Arg Thr Glu Gly Ala Gly Pro
    850                 855                 860                 
Gln Ala Asn Gly His Ile Glu Ser Asn Gly Val Cys Pro Arg Asp Ala
865                 870                 875                 880 
Ser His Phe Pro Glu Pro Asp Thr His Ser Val Ala Cys Arg Gln Pro
                885                 890                 895     
Lys Leu Cys Ala Gly Ser Ala Tyr His Lys Glu Pro Trp Lys Ala Ile
            900                 905                 910         
Glu Lys Ala Glu Gly Thr Pro Gly Pro His Lys Met Glu His Gly Gly
        915                 920                 925             
Arg Val Val Cys Ser Asp Cys Asn Thr Glu Val Asp Cys Tyr Ser Arg
    930                 935                 940                 
Gly Gln Ala Phe His Pro Gln Pro Val Ser Arg Asp Ser Ala Gln Pro
945                 950                 955                 960 
Ser Ala Pro Asn Gly Pro Glu Pro Gly Gly Ser Asp Gln Glu His Ser
                965                 970                 975     
Pro His His Gln Cys Ser Arg Thr Ala Ala Gly Ser Cys Pro Glu Cys
            980                 985                 990         
Gln Gly Ser Leu Tyr Pro Ser Asn His Asp Arg Met Leu Thr Ala Val
        995                 1000                1005            
Lys Lys Lys Pro Met Ala Ser Leu Asp Gly Lys Gly Asp Ser Ser Trp
    1010                1015                1020                
Thr Leu Ala Arg Leu Tyr His Pro Asp Ser Thr Glu Leu Gln Pro Ala
1025                1030                1035                1040
Ser Ser Leu Thr Ser Gly Ser Pro Glu Arg Ala Glu Ala Gln Tyr Leu
                1045                1050                1055    
Leu Val Ser Asn Gly His Leu Pro Lys Ala Cys Asp Ala Ser Pro Glu
            1060                1065                1070        
Ser Thr Pro Leu Thr Gly Gln Leu Pro Gly Lys Gln Arg Val Pro Leu
        1075                1080                1085            
Leu Leu Ala Pro Lys Ser
    1090                


<210> 8691
<211> 1331
<212> PRT
<213> Homo sapiens

<400> 8691
Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp
 1               5                  10                  15      
Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser
            20                  25                  30          
Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe
        35                  40                  45              
Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys
    50                  55                  60                  
Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp
65                  70                  75                  80  
His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser
                85                  90                  95      
Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln
            100                 105                 110         
Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His
        115                 120                 125             
Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly
    130                 135                 140                 
Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg
145                 150                 155                 160 
Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile
                165                 170                 175     
Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly
            180                 185                 190         
His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu
        195                 200                 205             
Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val
    210                 215                 220                 
Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu
225                 230                 235                 240 
Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu
                245                 250                 255     
Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp
            260                 265                 270         
Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile
        275                 280                 285             
Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu
    290                 295                 300                 
Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro
305                 310                 315                 320 
Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys
                325                 330                 335     
Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg
            340                 345                 350         
Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys
        355                 360                 365             
Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu
    370                 375                 380                 
Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln
385                 390                 395                 400 
Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala
                405                 410                 415     
Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly
            420                 425                 430         
Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser
        435                 440                 445             
Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu
    450                 455                 460                 
Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser
465                 470                 475                 480 
Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr
                485                 490                 495     
Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val
            500                 505                 510         
Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp
        515                 520                 525             
Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe
    530                 535                 540                 
Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro
545                 550                 555                 560 
Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe
                565                 570                 575     
Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Asn
            580                 585                 590         
Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln Thr
        595                 600                 605             
Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly Pro
    610                 615                 620                 
Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile Val
625                 630                 635                 640 
Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro Glu
                645                 650                 655     
Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln Ile
            660                 665                 670         
Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser Tyr
        675                 680                 685             
Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro Tyr
    690                 695                 700                 
Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly Gly
705                 710                 715                 720 
Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn Cys
                725                 730                 735     
Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln Trp
            740                 745                 750         
Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val Ser
        755                 760                 765             
Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu
    770                 775                 780                 
Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala
785                 790                 795                 800 
Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe Gln
                805                 810                 815     
Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro
            820                 825                 830         
Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys Leu
        835                 840                 845             
Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly Asn
    850                 855                 860                 
Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp Asp
865                 870                 875                 880 
Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser Leu
                885                 890                 895     
Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly
            900                 905                 910         
His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly
        915                 920                 925             
Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn Gly
    930                 935                 940                 
Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe Ile
945                 950                 955                 960 
Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn
                965                 970                 975     
Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser
            980                 985                 990         
Asn Thr Ala Tyr Asp Gly Thr Phe Cys Asn Lys Asp Val Gly Ala Phe
        995                 1000                1005            
Phe Glu Glu Gly Met Trp Leu Arg Tyr Asn Phe Gln Ala Pro Ala Thr
    1010                1015                1020                
Asn Ala Arg Asp Ser Ser Ser Arg Val Asp Asn Ala Pro Asp Gln Gln
1025                1030                1035                1040
Asn Ser His Pro Asp Leu Ala Gln Glu Glu Ile Arg Phe Ser Phe Ser
                1045                1050                1055    
Thr Thr Lys Ala Pro Cys Ile Leu Leu Tyr Ile Ser Ser Phe Thr Thr
            1060                1065                1070        
Asp Phe Leu Ala Val Leu Val Lys Pro Thr Gly Ser Leu Gln Ile Arg
        1075                1080                1085            
Tyr Asn Leu Gly Gly Thr Arg Glu Pro Tyr Asn Ile Asp Val Asp His
    1090                1095                1100                
Arg Asn Met Ala Asn Gly Gln Pro His Ser Val Asn Ile Thr Arg His
1105                1110                1115                1120
Glu Lys Thr Ile Phe Leu Lys Leu Asp His Tyr Pro Ser Val Ser Tyr
                1125                1130                1135    
His Leu Pro Ser Ser Ser Asp Thr Leu Phe Asn Ser Pro Lys Ser Leu
            1140                1145                1150        
Phe Leu Gly Lys Val Ile Glu Thr Gly Lys Ile Asp Gln Glu Ile His
        1155                1160                1165            
Lys Tyr Asn Thr Pro Gly Phe Thr Gly Cys Leu Ser Arg Val Gln Phe
    1170                1175                1180                
Asn Gln Ile Ala Pro Leu Lys Ala Ala Leu Arg Gln Thr Asn Ala Ser
1185                1190                1195                1200
Ala His Val His Ile Gln Gly Glu Leu Val Glu Ser Asn Cys Gly Ala
                1205                1210                1215    
Ser Pro Leu Thr Leu Ser Pro Met Ser Ser Ala Thr Asp Pro Trp His
            1220                1225                1230        
Leu Asp His Leu Asp Ser Ala Ser Ala Asp Phe Pro Tyr Asn Pro Gly
        1235                1240                1245            
Gln Gly Gln Ala Ile Arg Asn Gly Val Asn Arg Asn Ser Ala Ile Ile
    1250                1255                1260                
Gly Gly Val Ile Ala Val Val Ile Phe Thr Ile Leu Cys Thr Leu Val
1265                1270                1275                1280
Phe Leu Ile Arg Tyr Met Phe Arg His Lys Gly Thr Tyr His Thr Asn
                1285                1290                1295    
Glu Ala Lys Gly Ala Glu Ser Ala Glu Ser Ala Asp Ala Ala Ile Met
            1300                1305                1310        
Asn Asn Asp Pro Asn Phe Thr Glu Thr Ile Asp Glu Ser Lys Lys Glu
        1315                1320                1325            
Trp Leu Ile
    1330    


<210> 8692
<211> 179
<212> PRT
<213> Homo sapiens

<400> 8692
Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln
            20                  25                  30          
Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly
        35                  40                  45              
Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp
    50                  55                  60                  
Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu
65                  70                  75                  80  
Leu Glu Lys Asn Gln Leu Leu Ala Pro Gly Tyr Ile Glu Thr His Tyr
                85                  90                  95      
Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Val Arg
            100                 105                 110         
Cys Phe His Gly Leu Trp Asp Ala Pro Pro Glu Gly Arg Arg Glu Ala
        115                 120                 125             
Arg Arg Thr Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr
    130                 135                 140                 
Leu Phe Leu Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu
145                 150                 155                 160 
Leu Glu Val Ala Asn Tyr Val Asp Gln Val Val Asn Ser Ala Gly Asp
                165                 170                 175     
Ala His Gly
            


<210> 8693
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 8693
Met Glu Ala Ala Arg Thr Glu Arg Pro Ala Gly Arg Pro Gly Ala Pro
 1               5                  10                  15      
Leu Val Arg Thr Gly Leu Leu Leu Leu Ser Thr Trp Val Leu Ala Gly
            20                  25                  30          
Ala Glu Ile Thr Trp Asp Ala Thr Gly Gly Pro Gly Arg Pro Ala Ala
        35                  40                  45              
Pro Ala Ser Arg Pro Pro Ala Leu Ser Pro Leu Ser Pro Arg Ala Val
    50                  55                  60                  
Ala Ser Gln Trp Pro Glu Glu Leu Ala Ser Ala Arg Arg Ala Ala Val
65                  70                  75                  80  
Leu Gly Arg Arg Ala Gly Pro Glu Leu Leu Pro Gln Gln Gly Gly Gly
                85                  90                  95      
Arg Gly Gly Glu Met Gln Val Glu Ala Gly Gly Thr Ser Pro Ala Gly
            100                 105                 110         
Glu Arg Arg Gly Arg Gly Ile Pro Ala Pro Ala Lys Leu Gly Gly Ala
        115                 120                 125             
Arg Arg Ser Arg Arg Ala Gln Pro Pro Ile Thr Gln Glu Arg Gly Asp
    130                 135                 140                 
Ala Trp Ala Thr Ala Pro Ala Asp Gly Ser Arg Gly Ser Arg Pro Leu
145                 150                 155                 160 
Ala Lys Gly Ser Arg Glu Glu Val Lys Ala Pro Arg Ala Gly Gly Ser
                165                 170                 175     
Ala Ala Glu Asp Leu Arg Leu Pro Ser Thr Ser Phe Ala Leu Thr Gly
            180                 185                 190         
Asp Ser Ala His Asn Gln Ala Met Val His Trp Ser Gly His Asn Ser
        195                 200                 205             
Ser Val Ile Leu Ile Leu Thr Lys Leu Tyr Asp Phe Asn Leu Gly Ser
    210                 215                 220                 
Val Thr Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr
225                 230                 235                 240 
Glu Lys Leu Asn Asp Lys Val Gly Leu Lys Thr Val Leu Ser Tyr Leu
                245                 250                 255     
Tyr Val Asn Pro Thr Asn Lys Arg Lys Ile Met Leu Leu Ser Asp Pro
            260                 265                 270         
Glu Met Glu Ser Ser Ile Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr
        275                 280                 285             
Gln Lys Tyr Arg Leu Thr Phe Tyr Ile Gln Ser Leu Leu Phe His Pro
    290                 295                 300                 
Lys Gln Glu Asp Trp Val Leu Ala Tyr Ser Leu Asp Gln Lys Leu Tyr
305                 310                 315                 320 
Ser Ser Met Asp Phe Gly Arg Arg Trp Gln Leu Met His Glu Arg Ile
                325                 330                 335     
Thr Pro Asn Arg Phe Tyr Trp Ser Val Ala Gly Leu Asp Lys Glu Ala
            340                 345                 350         
Asp Leu Val His Met Glu Val Arg Thr Thr Asp Gly Tyr Ala His Tyr
        355                 360                 365             
Leu Thr Cys Arg Ile Gln Glu Cys Ala Glu Thr Thr Arg Ser Gly Pro
    370                 375                 380                 
Phe Ala Arg Ser Ile Asp Ile Ser Ser Leu Val Val Gln Asp Glu Tyr
385                 390                 395                 400 
Ile Phe Ile Gln Val Thr Thr Ser Gly Arg Ala Ser Tyr Tyr Val Ser
                405                 410                 415     
Tyr Arg Arg Glu Ala Phe Ala Gln Ile Lys Leu Pro Lys Tyr Ser Leu
            420                 425                 430         
Pro Lys Asp Met His Ile Ile Ser Thr Asp Glu Asn Gln Val Phe Ala
        435                 440                 445             
Ala Val Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser
    450                 455                 460                 
Asp Thr Arg Gly Ile Tyr Phe Thr Leu Ala Met Glu Asn Ile Lys Ser
465                 470                 475                 480 
Ser Arg Gly Leu Met Gly Asn Ile Ile Ile Glu Leu Tyr Glu Val Ala
                485                 490                 495     
Gly Ile Lys Gly Ile Phe Leu Ala Asn Lys Lys Val Asp Asp Gln Val
            500                 505                 510         
Lys Thr Tyr Ile Thr Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln
        515                 520                 525             
Ala Pro Asp Val Asp Leu Arg Gly Ser Pro Val His Cys Leu Leu Pro
    530                 535                 540                 
Phe Cys Ser Leu His Leu His Leu Gln Leu Ser Glu Asn Pro Tyr Ser
545                 550                 555                 560 
Ser Gly Arg Ile Ser Ser Lys Glu Thr Ala Pro Gly Leu Val Val Ala
                565                 570                 575     
Thr Gly Asn Ile Gly Pro Glu Leu Ser Tyr Thr Asp Ile Gly Val Phe
            580                 585                 590         
Ile Ser Ser Asp Gly Gly Asn Thr Trp Arg Gln Ile Phe Asp Glu Glu
        595                 600                 605             
Tyr Asn Val Trp Phe Leu Asp Trp Gly Gly Ala Leu Val Ala Met Lys
    610                 615                 620                 
His Thr Pro Leu Pro Val Arg His Leu Trp Val Ser Phe Asp Glu Gly
625                 630                 635                 640 
His Ser Trp Asp Lys Tyr Gly Phe Thr Ser Val Pro Leu Phe Val Asp
                645                 650                 655     
Gly Ala Leu Val Glu Ala Gly Met Glu Thr His Ile Met Thr Val Phe
            660                 665                 670         
Gly His Phe Ser Leu Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr
        675                 680                 685             
Lys Ser Ile Phe Ser Arg His Cys Thr Lys Glu Asp Tyr Gln Thr Trp
    690                 695                 700                 
His Leu Leu Asn Gln Gly Glu Pro Cys Val Met Gly Glu Arg Lys Ile
705                 710                 715                 720 
Phe Lys Lys Arg Lys Pro Gly Ala Gln Cys Ala Leu Gly Arg Asp His
                725                 730                 735     
Ser Gly Ser Val Val Ser Glu Pro Cys Val Cys Ala Asn Trp Asp Phe
            740                 745                 750         
Glu Cys Asp Tyr Gly Tyr Glu Arg His Gly Glu Ser Gln Cys Val Pro
        755                 760                 765             
Ala Phe Trp Tyr Asn Pro Ala Ser Pro Ser Lys Asp Cys Ser Leu Gly
    770                 775                 780                 
Gln Ser Tyr Leu Asn Ser Thr Gly Tyr Arg Arg Ile Val Ser Asn Asn
785                 790                 795                 800 
Cys Thr Asp Gly Leu Arg Glu Lys Tyr Thr Ala Lys Ala Gln Met Cys
                805                 810                 815     
Pro Gly Lys Ala Pro Arg Gly Leu His Val Val Thr Thr Asp Gly Arg
            820                 825                 830         
Leu Val Ala Glu Gln Gly His Asn Ala Thr Phe Ile Ile Leu Met Glu
        835                 840                 845             
Glu Gly Asp Leu Gln Arg Thr Asn Ile Gln Leu Asp Phe Gly Asp Gly
    850                 855                 860                 
Ile Ala Val Ser Tyr Ala Asn Phe Ser Pro Ile Glu Asp Gly Ile Lys
865                 870                 875                 880 
His Val Tyr Lys Ser Ala Gly Ile Phe Gln Val Thr Ala Tyr Ala Glu
                885                 890                 895     
Asn Asn Leu Gly Ser Asp Thr Ala Val Leu Phe Leu His Val Val Cys
            900                 905                 910         
Pro Val Glu His Val His Leu Arg Val Pro Phe Val Ala Ile Arg Asn
        915                 920                 925             
Lys Glu Val Asn Ile Ser Ala Val Val Trp Pro Ser Gln Leu Gly Thr
    930                 935                 940                 
Leu Thr Tyr Phe Trp Trp Phe Gly Asn Ser Thr Lys Pro Leu Ile Thr
945                 950                 955                 960 
Leu Asp Ser Ser Ile Ser Phe Thr Phe Leu Ala Glu Gly Thr Asp Thr
                965                 970                 975     
Ile Thr Val Gln Val Ala Ala Gly Asn Ala Leu Ile Gln Asp Thr Lys
            980                 985                 990         
Glu Ile Ala Val His Glu Tyr Phe Gln Ser Gln Leu Leu Ser Phe Ser
        995                 1000                1005            
Pro Asn Leu Asp Tyr His Asn Pro Asp Ile Pro Glu Trp Arg Lys Asp
    1010                1015                1020                
Ile Gly Asn Val Ile Lys Arg Ala Leu Val Lys Val Thr Ser Val Pro
1025                1030                1035                1040
Glu Asp Gln Ile Leu Ile Ala Val Phe Pro Gly Leu Pro Thr Ser Ala
                1045                1050                1055    
Glu Leu Phe Ile Leu Pro Pro Lys Asn Leu Thr Glu Arg Arg Lys Gly
            1060                1065                1070        
Asn Glu Gly Asp Leu Glu Gln Ile Val Glu Thr Leu Phe Asn Ala Leu
        1075                1080                1085            
Asn Gln Asn Leu Val Gln Phe Glu Leu Lys Pro Gly Val Gln Val Ile
    1090                1095                1100                
Val Tyr Val Thr Gln Leu Thr Leu Ala Pro Leu Val Asp Ser Ser Ala
1105                1110                1115                1120
Gly His Ser Ser Ser Ala Met Leu Met Leu Leu Ser Val Val Phe Val
                1125                1130                1135    
Gly Leu Ala Val Phe Leu Ile Tyr Lys Phe Lys Arg Lys Ile Pro Trp
            1140                1145                1150        
Ile Asn Ile Tyr Ala Gln Val Gln His Asp Lys Glu Gln Glu Met Ile
        1155                1160                1165            
Gly Ser Val Ser Gln Ser Glu Asn Ala Pro Lys Ile Thr Leu Ser Asp
    1170                1175                1180                
Phe Thr Glu Pro Glu Glu Leu Leu Asp Lys Glu Leu Asp Thr Arg Val
1185                1190                1195                1200
Ile Gly Gly Ile Ala Thr Ile Ala Asn Ser Glu Ser Thr Lys Glu Ile
                1205                1210                1215    
Pro Asn Cys Thr Ser Val
            1220        


<210> 8694
<211> 769
<212> PRT
<213> Homo sapiens

<400> 8694
Met Cys Gly Ser Ala Leu Ala Phe Phe Thr Ala Ala Phe Val Cys Leu
 1               5                  10                  15      
Gln Asn Asp Arg Arg Gly Pro Ala Ser Phe Leu Trp Ala Ala Trp Val
            20                  25                  30          
Phe Ser Leu Val Leu Gly Leu Gly Gln Gly Glu Asp Asn Arg Cys Ala
        35                  40                  45              
Ser Ser Asn Ala Ala Ser Cys Ala Arg Cys Leu Ala Leu Gly Pro Glu
    50                  55                  60                  
Cys Gly Trp Cys Val Gln Glu Asp Phe Ile Ser Gly Gly Ser Arg Ser
65                  70                  75                  80  
Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly Cys Ser Val
                85                  90                  95      
Asp Ser Ile Glu Tyr Pro Ser Val His Val Ile Ile Pro Thr Glu Asn
            100                 105                 110         
Glu Ile Asn Thr Gln Val Thr Pro Gly Glu Val Ser Ile Gln Leu Arg
        115                 120                 125             
Pro Gly Ala Glu Ala Asn Phe Met Leu Lys Val His Pro Leu Lys Lys
    130                 135                 140                 
Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala Ser Met His
145                 150                 155                 160 
Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu Ser Arg Lys
                165                 170                 175     
Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly Ser Tyr Val
            180                 185                 190         
Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu Arg Ile His
        195                 200                 205             
Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro His Gly Tyr
    210                 215                 220                 
Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe Glu Lys Ala
225                 230                 235                 240 
Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro Glu Gly Gly
                245                 250                 255     
Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His Ile Gly Trp
            260                 265                 270         
Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp Gln Thr Ser
        275                 280                 285             
His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val Pro Asn Asp
    290                 295                 300                 
Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser Thr Thr Met
305                 310                 315                 320 
Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile Asp Asn Asn
                325                 330                 335     
Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His Trp Tyr Lys
            340                 345                 350         
Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu Ile Glu Ser
        355                 360                 365             
Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr Gln Lys Leu
    370                 375                 380                 
Ile Ser Glu Val Lys Val Gln Val Glu Asn Gln Val Gln Gly Ile Tyr
385                 390                 395                 400 
Phe Asn Ile Thr Ala Ile Cys Pro Asp Gly Ser Arg Lys Pro Gly Met
                405                 410                 415     
Glu Gly Cys Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val
            420                 425                 430         
Thr Val Thr Met Lys Lys Cys Asp Val Thr Gly Gly Lys Asn Tyr Ala
        435                 440                 445             
Ile Ile Lys Pro Ile Gly Phe Asn Glu Thr Ala Lys Ile His Ile His
    450                 455                 460                 
Arg Asn Cys Ser Cys Gln Cys Glu Asp Asn Arg Gly Pro Lys Gly Lys
465                 470                 475                 480 
Cys Val Asp Glu Thr Phe Leu Asp Ser Lys Cys Phe Gln Cys Asp Glu
                485                 490                 495     
Asn Lys Cys His Phe Asp Glu Asp Gln Phe Ser Ser Glu Ser Cys Lys
            500                 505                 510         
Ser His Lys Asp Gln Pro Val Cys Ser Gly Arg Gly Val Cys Val Cys
        515                 520                 525             
Gly Lys Cys Ser Cys His Lys Ile Lys Leu Gly Lys Val Tyr Gly Lys
    530                 535                 540                 
Tyr Cys Glu Lys Asp Asp Phe Ser Cys Pro Tyr His His Gly Asn Leu
545                 550                 555                 560 
Cys Ala Gly His Gly Glu Cys Glu Ala Gly Arg Cys Gln Cys Phe Ser
                565                 570                 575     
Gly Trp Glu Gly Asp Arg Cys Gln Cys Pro Ser Ala Ala Ala Gln His
            580                 585                 590         
Cys Val Asn Ser Lys Gly Gln Val Cys Ser Gly Arg Gly Thr Cys Val
        595                 600                 605             
Cys Gly Arg Cys Glu Cys Thr Asp Pro Arg Ser Ile Gly Arg Phe Cys
    610                 615                 620                 
Glu His Cys Pro Thr Cys Tyr Thr Ala Cys Lys Glu Asn Trp Asn Cys
625                 630                 635                 640 
Met Gln Cys Leu His Pro His Asn Leu Ser Gln Ala Ile Leu Asp Gln
                645                 650                 655     
Cys Lys Thr Ser Cys Ala Leu Met Glu Gln Gln His Tyr Val Asp Gln
            660                 665                 670         
Thr Ser Glu Cys Phe Ser Ser Pro Ser Tyr Leu Arg Ile Phe Phe Ile
        675                 680                 685             
Ile Phe Ile Val Thr Phe Leu Ile Gly Leu Leu Lys Val Leu Ile Ile
    690                 695                 700                 
Arg Gln Val Ile Leu Gln Trp Asn Ser Asn Lys Ile Lys Ser Ser Ser
705                 710                 715                 720 
Asp Tyr Arg Val Ser Ala Ser Lys Lys Asp Lys Leu Ile Leu Gln Ser
                725                 730                 735     
Val Cys Thr Arg Ala Val Thr Tyr Arg Arg Glu Lys Pro Glu Glu Ile
            740                 745                 750         
Lys Met Asp Ile Ser Lys Leu Asn Ala His Glu Thr Phe Arg Cys Asn
        755                 760                 765             
Phe
    


<210> 8695
<211> 306
<212> PRT
<213> Homo sapiens

<400> 8695
Met Ser Thr Trp Lys Ala Arg Leu Thr Lys Arg Leu Lys Ser Pro Ser
 1               5                  10                  15      
Arg Ser Met His Pro Phe Pro Cys Ser Ala Leu Leu Ala Cys Phe Gly
            20                  25                  30          
Asn Thr Arg Glu Ser Ala Ser Phe Asn Gln Ser Gly Val Ala Asp Thr
        35                  40                  45              
His Ser Thr Val Arg Val Gln Pro Val Ala Lys Ala Gly Arg Gln Pro
    50                  55                  60                  
Arg His Pro Ser Ala Glu Gly Ala Pro Glu Lys Arg Gln Asp Ser Ser
65                  70                  75                  80  
Thr His Ala Glu Arg Asn Gly Ser Ala Asn Arg Asn Ser Ser His Arg
                85                  90                  95      
Thr Ala Ala Gln Pro Ala Glu Thr Pro Glu Asp Val Pro Gly Ser Leu
            100                 105                 110         
Asp Asp Gly Ala Asp Cys Glu Ala Val Val Phe His Ala Ser Ile Pro
        115                 120                 125             
Arg Pro Ser Ile Ile Asp Thr Pro Lys Glu Glu Glu Phe Arg Glu Glu
    130                 135                 140                 
Pro Lys Cys Leu Glu Leu Glu Gln Lys Met Thr Ser Asp Ser Pro Pro
145                 150                 155                 160 
Glu Asp Ile Asp His Lys Asp Ser Tyr Leu Ile Thr Arg Ser Ile Met
                165                 170                 175     
Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg Pro
            180                 185                 190         
Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp Leu
        195                 200                 205             
His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln Asn
    210                 215                 220                 
Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln Val
225                 230                 235                 240 
Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu Glu
                245                 250                 255     
Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu Glu
            260                 265                 270         
Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val Lys
        275                 280                 285             
Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala Gln
    290                 295                 300                 
Glu Ser
305     


<210> 8696
<211> 284
<212> PRT
<213> Homo sapiens

<400> 8696
Ala Arg Gly Arg Leu Arg Arg Ser Ala Arg Arg Met Asp Pro Val Pro
 1               5                  10                  15      
Gly Thr Asp Ser Ala Pro Leu Ala Gly Leu Ala Trp Ser Ser Ala Ser
            20                  25                  30          
Ala Pro Pro Pro Arg Gly Phe Ser Ala Ile Ser Cys Thr Val Glu Gly
        35                  40                  45              
Ala Pro Ala Ser Phe Gly Lys Ser Phe Ala Gln Lys Ser Gly Tyr Phe
    50                  55                  60                  
Leu Cys Leu Ser Ser Leu Gly Ser Leu Glu Asn Pro Gln Glu Asn Val
65                  70                  75                  80  
Val Ala Asp Ile Gln Ile Val Val Asp Lys Ser Pro Leu Pro Leu Gly
                85                  90                  95      
Phe Ser Pro Val Cys Asp Pro Met Asp Ser Lys Ala Ser Val Ser Lys
            100                 105                 110         
Lys Lys Arg Met Cys Val Lys Leu Leu Pro Leu Gly Ala Thr Asp Thr
        115                 120                 125             
Ala Val Phe Asp Val Arg Leu Ser Gly Lys Thr Lys Thr Val Pro Gly
    130                 135                 140                 
Tyr Leu Arg Ile Gly Asp Met Gly Gly Phe Ala Ile Trp Cys Lys Lys
145                 150                 155                 160 
Ala Lys Ala Pro Arg Pro Val Pro Lys Pro Arg Gly Leu Ser Arg Asp
                165                 170                 175     
Met Gln Gly Leu Ser Leu Asp Ala Ala Ser Gln Pro Ser Lys Gly Gly
            180                 185                 190         
Leu Leu Glu Arg Thr Ala Ser Arg Leu Gly Ser Arg Ala Ser Thr Leu
        195                 200                 205             
Arg Arg Asn Asp Ser Ile Tyr Glu Ala Ser Ser Leu Tyr Gly Ile Ser
    210                 215                 220                 
Ala Met Asp Gly Val Pro Phe Thr Leu His Pro Arg Phe Glu Gly Lys
225                 230                 235                 240 
Ser Cys Ser Pro Leu Ala Phe Ser Ala Phe Gly Asp Leu Thr Ile Lys
                245                 250                 255     
Ser Leu Ala Asp Ile Glu Glu Glu Tyr Asn Tyr Gly Phe Val Val Glu
            260                 265                 270         
Lys Thr Ala Ala Ala Arg Leu Pro Pro Ser Val Ser
        275                 280                 


<210> 8697
<211> 162
<212> PRT
<213> Homo sapiens

<400> 8697
Trp Leu Gly Cys Val Cys Phe Ala Leu Val Gln Ala Asp Ser Pro Ser
 1               5                  10                  15      
Ala Pro Val Asn Val Thr Val Arg His Leu Lys Ala Asn Ser Ala Val
            20                  25                  30          
Val Ser Trp Asp Val Leu Glu Asp Glu Val Val Ile Gly Phe Ala Ile
        35                  40                  45              
Ser Gln Gln Lys Lys Asp Val Arg Met Leu Arg Phe Ile Gln Glu Val
    50                  55                  60                  
Asn Thr Thr Thr Arg Ser Cys Ala Leu Trp Asp Leu Glu Glu Asp Thr
65                  70                  75                  80  
Glu Tyr Ile Val His Val Gln Ala Ile Ser Ile Gln Gly Gln Ser Pro
                85                  90                  95      
Ala Ser Glu Pro Val Leu Phe Lys Thr Pro Arg Glu Ala Glu Lys Met
            100                 105                 110         
Ala Ser Lys Asn Lys Asp Glu Val Thr Met Lys Glu Met Gly Arg Asn
        115                 120                 125             
Gln Gln Leu Arg Thr Gly Glu Val Leu Ile Ile Val Val Val Leu Phe
    130                 135                 140                 
Met Trp Ala Gly Val Ile Ala Leu Phe Cys Arg Gln Tyr Asp Ile Ile
145                 150                 155                 160 
Glu Ala
        


<210> 8698
<211> 1912
<212> PRT
<213> Homo sapiens

<400> 8698
Thr Glu Arg Met Cys His Ala Ala Gln Glu Thr Pro Leu Leu His His
 1               5                  10                  15      
Phe Met Ala Pro Val Met Ala Arg Trp Pro Pro Phe Gly Leu Cys Leu
            20                  25                  30          
Leu Leu Leu Leu Leu Ser Pro Pro Pro Leu Pro Leu Thr Gly Ala His
        35                  40                  45              
Arg Phe Ser Ala Pro Asn Thr Thr Leu Asn His Leu Ala Leu Ala Pro
    50                  55                  60                  
Gly Arg Gly Thr Leu Tyr Val Gly Ala Val Asn Arg Leu Phe Gln Leu
65                  70                  75                  80  
Ser Pro Glu Leu Gln Leu Glu Ala Val Ala Val Thr Gly Pro Val Ile
                85                  90                  95      
Asp Ser Pro Asp Cys Val Pro Phe Arg Asp Pro Ala Glu Cys Pro Gln
            100                 105                 110         
Ala Gln Leu Thr Asp Asn Ala Asn Gln Leu Leu Leu Val Ser Ser Arg
        115                 120                 125             
Ala Gln Glu Leu Val Ala Cys Gly Gln Val Arg Gln Gly Val Cys Glu
    130                 135                 140                 
Thr Arg Arg Leu Gly Asp Val Ala Glu Val Leu Tyr Gln Ala Glu Asp
145                 150                 155                 160 
Pro Gly Asp Gly Gln Phe Val Ala Ala Asn Thr Pro Gly Val Ala Thr
                165                 170                 175     
Val Gly Leu Val Val Pro Leu Pro Gly Arg Asp Leu Leu Leu Val Ala
            180                 185                 190         
Arg Gly Leu Ala Gly Lys Leu Ser Ala Gly Val Pro Pro Leu Ala Ile
        195                 200                 205             
Arg Gln Leu Ala Gly Ser Gln Pro Phe Ser Ser Glu Gly Leu Gly Arg
    210                 215                 220                 
Leu Val Val Gly Asp Phe Ser Asp Tyr Asn Asn Ser Tyr Val Gly Ala
225                 230                 235                 240 
Phe Ala Asp Ala Arg Ser Ala Tyr Phe Val Phe Arg Arg Arg Gly Ala
                245                 250                 255     
Arg Ala Gln Ala Glu Tyr Arg Ser Tyr Val Ala Arg Val Cys Leu Gly
            260                 265                 270         
Asp Thr Asn Leu Tyr Ser Tyr Val Glu Val Pro Leu Ala Cys Gln Gly
        275                 280                 285             
Gln Gly Leu Ile Gln Ala Ala Phe Leu Ala Pro Gly Thr Leu Leu Gly
    290                 295                 300                 
Val Phe Ala Ala Gly Pro Arg Gly Thr Gln Ala Ala Leu Cys Ala Phe
305                 310                 315                 320 
Pro Met Val Glu Leu Gly Ala Ser Met Glu Gln Ala Arg Arg Leu Cys
                325                 330                 335     
Tyr Thr Ala Gly Gly Arg Gly Pro Ser Gly Ala Glu Glu Ala Thr Val
            340                 345                 350         
Glu Tyr Gly Val Thr Ser Arg Cys Val Thr Leu Pro Leu Asp Ser Pro
        355                 360                 365             
Glu Ser Tyr Pro Cys Gly Asp Glu His Thr Pro Ser Pro Ile Ala Gly
    370                 375                 380                 
Arg Gln Pro Leu Glu Val Gln Pro Leu Leu Lys Leu Gly Gln Pro Val
385                 390                 395                 400 
Ser Ala Val Ala Ala Leu Gln Ala Asp Gly His Met Ile Ala Phe Leu
                405                 410                 415     
Gly Asp Thr Gln Gly Gln Leu Tyr Lys Val Phe Leu His Gly Ser Gln
            420                 425                 430         
Gly Gln Val Tyr His Ser Gln Gln Val Gly Pro Pro Gly Ser Ala Ile
        435                 440                 445             
Ser Pro Asp Leu Leu Leu Asp Ser Ser Gly Ser His Leu Tyr Val Leu
    450                 455                 460                 
Thr Ala His Gln Val Asp Arg Ile Pro Val Ala Ala Cys Pro Gln Phe
465                 470                 475                 480 
Pro Asp Cys Ala Ser Cys Leu Gln Ala Gln Asp Pro Leu Cys Gly Trp
                485                 490                 495     
Cys Val Leu Gln Gly Arg Cys Thr Arg Lys Gly Gln Cys Gly Arg Ala
            500                 505                 510         
Gly Gln Leu Asn Gln Trp Leu Trp Ser Tyr Glu Glu Asp Ser His Cys
        515                 520                 525             
Leu His Ile Gln Ser Leu Leu Pro Gly His His Pro Arg Gln Glu Gln
    530                 535                 540                 
Gly Gln Val Thr Leu Ser Val Pro Arg Leu Pro Ile Leu Asp Ala Asp
545                 550                 555                 560 
Glu Tyr Phe His Cys Ala Phe Gly Asp Tyr Asp Ser Leu Ala His Val
                565                 570                 575     
Glu Gly Pro His Val Ala Cys Val Thr Pro Pro Gln Asp Gln Val Pro
            580                 585                 590         
Leu Asn Pro Pro Gly Thr Asp His Val Thr Val Pro Leu Ala Leu Met
        595                 600                 605             
Phe Glu Asp Val Thr Val Ala Ala Thr Asn Phe Ser Phe Tyr Asp Cys
    610                 615                 620                 
Ser Ala Val Gln Ala Leu Glu Ala Ala Ala Pro Cys Arg Ala Cys Val
625                 630                 635                 640 
Gly Ser Ile Trp Arg Cys His Trp Cys Pro Gln Ser Ser His Cys Val
                645                 650                 655     
Tyr Gly Glu His Cys Pro Glu Gly Glu Arg Thr Ile Tyr Ser Ala Gln
            660                 665                 670         
Glu Val Asp Ile Gln Val Arg Gly Pro Gly Ala Cys Pro Gln Val Glu
        675                 680                 685             
Gly Leu Ala Gly Pro His Leu Val Pro Val Gly Trp Glu Ser His Leu
    690                 695                 700                 
Ala Leu Arg Val Arg Asn Leu Gln His Phe Arg Gly Leu Pro Ala Ser
705                 710                 715                 720 
Phe His Cys Trp Leu Glu Leu Pro Gly Glu Leu Arg Gly Leu Pro Ala
                725                 730                 735     
Thr Leu Glu Glu Thr Ala Gly Asp Ser Gly Leu Ile His Cys Gln Ala
            740                 745                 750         
His Gln Phe Tyr Pro Ser Met Ser Gln Arg Glu Leu Pro Val Pro Ile
        755                 760                 765             
Tyr Val Thr Gln Gly Glu Ala Gln Arg Leu Asp Asn Thr His Ala Leu
    770                 775                 780                 
Tyr Val Ile Leu Tyr Asp Cys Ala Met Gly His Pro Asp Cys Ser His
785                 790                 795                 800 
Cys Gln Ala Ala Asn Arg Ser Leu Gly Cys Leu Trp Cys Ala Asp Gly
                805                 810                 815     
Gln Pro Ala Cys Arg Tyr Gly Pro Leu Cys Pro Pro Gly Ala Val Glu
            820                 825                 830         
Leu Leu Cys Pro Ala Pro Ser Ile Asp Ala Val Glu Pro Leu Thr Gly
        835                 840                 845             
Pro Pro Glu Gly Gly Leu Ala Leu Thr Ile Leu Gly Ser Asn Leu Gly
    850                 855                 860                 
Arg Ala Phe Ala Asp Val Gln Tyr Ala Val Ser Val Ala Ser Arg Pro
865                 870                 875                 880 
Cys Asn Pro Glu Pro Ser Leu Tyr Arg Thr Ser Ala Arg Ile Val Cys
                885                 890                 895     
Val Thr Ser Pro Ala Pro Asn Gly Thr Thr Gly Pro Val Arg Val Ala
            900                 905                 910         
Ile Lys Ser Gln Pro Pro Gly Ile Ser Ser Gln His Phe Thr Tyr Gln
        915                 920                 925             
Asp Pro Val Leu Leu Ser Leu Ser Pro Arg Trp Gly Pro Gln Ala Gly
    930                 935                 940                 
Gly Thr Gln Leu Thr Ile Arg Gly Gln His Leu Gln Thr Gly Gly Asn
945                 950                 955                 960 
Thr Ser Ala Phe Val Gly Gly Gln Pro Cys Pro Ile Leu Glu Pro Val
                965                 970                 975     
Cys Pro Glu Ala Ile Val Cys Arg Thr Arg Pro Gln Ala Ala Pro Gly
            980                 985                 990         
Glu Ala Ala Val Leu Val Val Phe Gly His Ala Gln Arg Thr Leu Leu
        995                 1000                1005            
Ala Ser Pro Phe Arg Tyr Thr Ala Asn Pro Gln Leu Val Ala Ala Glu
    1010                1015                1020                
Pro Ser Ala Ser Phe Arg Gly Gly Gly Arg Leu Ile Arg Val Arg Gly
1025                1030                1035                1040
Thr Gly Leu Asp Val Val Gln Arg Pro Leu Leu Ser Val Trp Leu Glu
                1045                1050                1055    
Ala Asp Ala Glu Val Gln Ala Ser Arg Ala Gln Pro Gln Asp Pro Gln
            1060                1065                1070        
Pro Arg Arg Ser Cys Gly Ala Pro Ala Ala Asp Pro Gln Ala Cys Ile
        1075                1080                1085            
Gln Leu Gly Gly Gly Leu Leu Gln Cys Ser Thr Val Cys Ser Val Asn
    1090                1095                1100                
Ser Ser Ser Leu Leu Leu Cys Arg Ser Pro Ala Val Pro Asp Arg Ala
1105                1110                1115                1120
His Pro Gln Arg Val Phe Phe Thr Leu Asp Asn Val Gln Val Asp Phe
                1125                1130                1135    
Ala Ser Ala Ser Gly Gly Gln Gly Phe Leu Tyr Gln Pro Asn Pro Arg
            1140                1145                1150        
Leu Ala Pro Leu Ser Arg Glu Gly Pro Ala Arg Pro Tyr Arg Leu Lys
        1155                1160                1165            
Pro Gly His Val Leu Asp Val Glu Gly Glu Gly Leu Asn Leu Gly Ile
    1170                1175                1180                
Ser Lys Glu Glu Val Arg Val His Ile Gly Arg Gly Glu Cys Leu Val
1185                1190                1195                1200
Lys Thr Leu Thr Arg Thr His Leu Tyr Cys Glu Pro Pro Ala His Ala
                1205                1210                1215    
Pro Gln Pro Ala Asn Gly Ser Gly Leu Pro Gln Phe Val Val Gln Met
            1220                1225                1230        
Gly Asn Val Gln Leu Ala Leu Gly Pro Val Gln Tyr Glu Ala Glu Pro
        1235                1240                1245            
Pro Leu Ser Ala Phe Pro Val Glu Ala Gln Ala Gly Val Gly Met Gly
    1250                1255                1260                
Ala Ala Val Leu Ile Ala Ala Val Leu Leu Leu Thr Leu Met Tyr Arg
1265                1270                1275                1280
His Lys Ser Lys Gln Ala Leu Arg Asp Tyr Gln Lys Val Leu Val Gln
                1285                1290                1295    
Leu Glu Ser Leu Glu Thr Gly Val Gly Asp Gln Cys Arg Lys Glu Phe
            1300                1305                1310        
Thr Asp Leu Met Thr Glu Met Thr Asp Leu Ser Ser Asp Leu Glu Gly
        1315                1320                1325            
Ser Gly Ile Pro Phe Leu Asp Tyr Arg Thr Tyr Ala Glu Arg Ala Phe
    1330                1335                1340                
Phe Pro Gly His Gly Gly Cys Pro Leu Gln Pro Lys Pro Glu Gly Pro
1345                1350                1355                1360
Gly Glu Asp Gly His Cys Ala Thr Val Arg Gln Gly Leu Thr Gln Leu
                1365                1370                1375    
Ser Asn Leu Leu Asn Ser Lys Leu Phe Leu Leu Thr Leu Ile His Thr
            1380                1385                1390        
Leu Glu Glu Gln Pro Ser Phe Ser Gln Arg Asp Arg Cys His Val Ala
        1395                1400                1405            
Ser Leu Leu Ser Leu Ala Leu His Gly Lys Leu Glu Tyr Leu Thr Asp
    1410                1415                1420                
Ile Met Arg Thr Leu Leu Gly Asp Leu Ala Ala His Tyr Val His Arg
1425                1430                1435                1440
Asn Pro Lys Leu Met Leu Arg Arg Thr Glu Thr Met Val Glu Lys Leu
                1445                1450                1455    
Leu Thr Asn Trp Leu Ser Ile Cys Leu Tyr Ala Phe Leu Arg Glu Val
            1460                1465                1470        
Ala Gly Glu Pro Leu Tyr Met Leu Phe Arg Ala Ile Gln Tyr Gln Val
        1475                1480                1485            
Asp Lys Gly Pro Val Asp Ala Val Thr Gly Lys Ala Lys Arg Thr Leu
    1490                1495                1500                
Asn Asp Ser Arg Leu Leu Arg Glu Asp Val Glu Phe Gln Pro Leu Thr
1505                1510                1515                1520
Leu Met Val Leu Val Gly Pro Gly Ala Gly Gly Ala Ala Gly Ser Ser
                1525                1530                1535    
Glu Met Gln Arg Val Pro Ala Arg Val Leu Asp Thr Asp Thr Ile Thr
            1540                1545                1550        
Gln Val Lys Glu Lys Val Leu Asp Gln Val Tyr Lys Gly Thr Pro Phe
        1555                1560                1565            
Ser Gln Arg Pro Ser Val His Ala Leu Asp Leu Glu Trp Arg Ser Gly
    1570                1575                1580                
Leu Ala Gly His Leu Thr Leu Ser Asp Glu Asp Leu Thr Ser Val Thr
1585                1590                1595                1600
Gln Asn His Trp Lys Arg Leu Asn Thr Leu Gln His Tyr Lys Val Pro
                1605                1610                1615    
Asp Gly Ala Thr Val Gly Leu Val Pro Gln Leu His Arg Gly Ser Thr
            1620                1625                1630        
Ile Ser Gln Ser Leu Ala Gln Arg Cys Pro Leu Gly Glu Asn Ile Pro
        1635                1640                1645            
Thr Leu Glu Asp Gly Glu Glu Gly Gly Val Cys Leu Trp His Leu Val
    1650                1655                1660                
Lys Ala Thr Glu Glu Pro Glu Gly Ala Lys Val Arg Cys Ser Ser Leu
1665                1670                1675                1680
Arg Glu Arg Glu Pro Ala Arg Ala Lys Ala Ile Pro Glu Ile Tyr Leu
                1685                1690                1695    
Thr Arg Leu Leu Ser Met Lys Gly Thr Leu Gln Lys Phe Val Asp Asp
            1700                1705                1710        
Thr Phe Gln Ala Ile Leu Ser Val Asn Arg Pro Ile Pro Ile Ala Val
        1715                1720                1725            
Lys Tyr Leu Phe Asp Leu Leu Asp Glu Leu Ala Glu Lys His Gly Ile
    1730                1735                1740                
Glu Asp Pro Gly Thr Leu His Ile Trp Lys Thr Asn Ser Leu Leu Leu
1745                1750                1755                1760
Arg Phe Trp Val Asn Ala Leu Lys Asn Pro Gln Leu Ile Phe Asp Val
                1765                1770                1775    
Arg Val Ser Asp Asn Val Asp Ala Ile Leu Ala Val Ile Ala Gln Thr
            1780                1785                1790        
Phe Ile Asp Ser Cys Thr Thr Ser Glu His Lys Val Gly Arg Asp Ser
        1795                1800                1805            
Pro Val Asn Lys Leu Leu Tyr Ala Arg Glu Ile Pro Arg Tyr Lys Gln
    1810                1815                1820                
Met Val Glu Arg Tyr Tyr Ala Asp Ile Arg Gln Ser Ser Pro Ala Ser
1825                1830                1835                1840
Tyr Gln Glu Met Asn Ser Ala Leu Ala Glu Leu Ser Gly Asn Tyr Thr
                1845                1850                1855    
Ser Ala Pro His Cys Leu Glu Ala Leu Gln Glu Leu Tyr Asn His Ile
            1860                1865                1870        
His Arg Tyr Tyr Asp Gln Ile Ile Ser Ala Leu Glu Glu Asp Pro Val
        1875                1880                1885            
Gly Gln Lys Leu Gln Leu Ala Cys Arg Leu Gln Gln Val Ala Ala Leu
    1890                1895                1900                
Val Glu Asn Lys Val Thr Asp Leu
1905                1910        


<210> 8699
<211> 453
<212> PRT
<213> Homo sapiens

<400> 8699
Met Lys Leu Leu Val Ile Leu Leu Phe Ser Gly Leu Ile Thr Gly Phe
 1               5                  10                  15      
Arg Ser Asp Ser Ser Ser Ser Leu Pro Pro Lys Leu Leu Leu Val Ser
            20                  25                  30          
Phe Asp Gly Phe Arg Ala Asp Tyr Leu Lys Asn Tyr Glu Phe Pro His
        35                  40                  45              
Leu Gln Asn Phe Ile Lys Glu Gly Val Leu Val Glu His Val Lys Asn
    50                  55                  60                  
Val Phe Ile Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly
65                  70                  75                  80  
Leu Tyr Glu Glu Ser His Gly Ile Val Ala Asn Ser Met Tyr Asp Ala
                85                  90                  95      
Val Thr Lys Lys His Phe Ser Asp Ser Asn Asp Lys Asp Pro Phe Trp
            100                 105                 110         
Trp Asn Glu Ala Val Pro Ile Trp Val Thr Asn Gln Leu Gln Glu Asn
        115                 120                 125             
Arg Ser Ser Ala Ala Ala Met Trp Pro Gly Thr Asp Val Pro Ile His
    130                 135                 140                 
Asp Thr Ile Ser Ser Tyr Phe Met Asn Tyr Asn Ser Ser Val Ser Phe
145                 150                 155                 160 
Glu Glu Arg Leu Asn Asn Ile Thr Met Trp Leu Asn Asn Ser Asn Pro
                165                 170                 175     
Pro Val Thr Phe Ala Thr Leu Tyr Trp Glu Glu Pro Asp Ala Ser Gly
            180                 185                 190         
His Lys Tyr Gly Pro Glu Asp Lys Glu Asn Met Ser Arg Val Leu Lys
        195                 200                 205             
Lys Ile Asp Asp Leu Ile Gly Asp Leu Val Gln Arg Leu Lys Met Leu
    210                 215                 220                 
Gly Leu Trp Glu Asn Leu Asn Val Ile Ile Thr Ser Asp His Gly Met
225                 230                 235                 240 
Thr Gln Cys Ser Gln Asp Arg Leu Ile Asn Leu Asp Ser Cys Ile Asp
                245                 250                 255     
His Ser Tyr Tyr Thr Leu Ile Asp Leu Ser Pro Val Ala Ala Ile Leu
            260                 265                 270         
Pro Lys Ile Asn Arg Thr Glu Val Tyr Asn Lys Leu Lys Asn Cys Ser
        275                 280                 285             
Pro His Met Asn Val Tyr Leu Lys Glu Asp Ile Pro Asn Arg Phe Tyr
    290                 295                 300                 
Tyr Gln His Asn Asp Arg Ile Gln Pro Ile Ile Leu Val Ala Asp Glu
305                 310                 315                 320 
Gly Trp Thr Ile Val Leu Asn Glu Ser Ser Gln Lys Leu Gly Asp His
                325                 330                 335     
Gly Tyr Asp Asn Ser Leu Pro Ser Met His Pro Phe Leu Ala Ala His
            340                 345                 350         
Gly Pro Ala Phe His Lys Gly Tyr Lys His Ser Thr Ile Asn Ile Val
        355                 360                 365             
Asp Ile Tyr Pro Met Met Cys His Ile Leu Gly Leu Lys Pro His Pro
    370                 375                 380                 
Asn Asn Gly Thr Phe Gly His Thr Lys Cys Leu Leu Val Asp Gln Trp
385                 390                 395                 400 
Cys Ile Asn Leu Pro Glu Ala Ile Ala Ile Val Ile Gly Ser Leu Leu
                405                 410                 415     
Val Leu Thr Met Leu Thr Cys Leu Ile Ile Ile Met Gln Asn Arg Leu
            420                 425                 430         
Ser Val Pro Arg Pro Phe Ser Arg Leu Gln Leu Gln Glu Asp Asp Asp
        435                 440                 445             
Asp Pro Leu Ile Gly
    450             


<210> 8700
<211> 740
<212> PRT
<213> Homo sapiens

<400> 8700
Glu Ser Glu Pro Gln Pro Glu Pro Cys Pro Gly Arg Ala Gly Ala Ala
 1               5                  10                  15      
Ala Arg Ala Arg Trp Cys Pro Gln Pro Arg Pro Leu Val Leu Leu Ser
            20                  25                  30          
Leu Gly Ala Leu Glu Phe Val Ser Leu Ser Gln Gln Ala Phe Gln Ile
        35                  40                  45              
Cys Pro Val Phe Val Val Cys Gly Leu Tyr Gln Asp Gly Asn Ser Asn
    50                  55                  60                  
Lys Ser Phe Leu Leu Arg Ser Trp Cys Leu His Pro Glu Gly Thr Val
65                  70                  75                  80  
Cys Ala Ser Ser Pro Glu Arg Lys Asp Leu Pro Glu Ala Leu Gly Asn
                85                  90                  95      
Asp Pro Gly Thr Pro Gly Gln Arg Gly Leu Lys Leu Phe Gly Lys Ala
            100                 105                 110         
Ala Gly Leu Leu Gly Lys Met Ala Met Ala Pro Ser Pro Ser Leu Val
        115                 120                 125             
Gln Val Tyr Thr Ser Pro Ala Ala Val Ala Val Trp Glu Trp Gln Asp
    130                 135                 140                 
Gly Leu Gly Thr Trp His Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile
145                 150                 155                 160 
Glu Gln Gln Phe Val Gln Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser
                165                 170                 175     
Leu Ala His Ser Ile Pro Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro
            180                 185                 190         
Tyr Ile Ile Asp Leu Pro Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly
        195                 200                 205             
Thr Met Arg Ala Val Arg Arg His Leu Phe Pro Gln His Ser Ala Pro
    210                 215                 220                 
Gly Arg Gly Val Val Trp Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr
225                 230                 235                 240 
Ala Tyr Glu Ala Ser Val Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg
                245                 250                 255     
Gly Asn Gln Leu Val Asp Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val
            260                 265                 270         
Asn Tyr Thr Thr His Thr Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg
        275                 280                 285             
Ser Val Arg Arg Gln Ala Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile
    290                 295                 300                 
Ala Pro Pro Gly His Thr Gly Val Ala Cys Ser Cys His Gln Cys Leu
305                 310                 315                 320 
Ser Gly Ser Arg Thr Gly Pro Val Ser Gly Arg Tyr Arg His Ser Met
                325                 330                 335     
Thr Asn Leu Pro Ala Tyr Pro Val Pro Gln His Pro Pro His Arg Thr
            340                 345                 350         
Ala Ser Val Phe Gly Thr His Gln Ala Phe Ala Pro Tyr Asn Lys Pro
        355                 360                 365             
Ser Leu Ser Gly Ala Arg Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala
    370                 375                 380                 
Trp Gly Ala Ala Pro Pro Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser
385                 390                 395                 400 
Ser Leu Ser His Leu Gly Pro Gln His Leu Pro Pro Gly Ser Ser Thr
                405                 410                 415     
Ser Gly Ala Val Ser Ala Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro
            420                 425                 430         
Gly Ser Val Pro Ala Thr Val Pro Met Gln Met Pro Lys Pro Ser Arg
        435                 440                 445             
Val Gln Gln Ala Leu Ala Gly Met Thr Ser Val Leu Met Ser Ala Ile
    450                 455                 460                 
Gly Leu Pro Val Cys Leu Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro
465                 470                 475                 480 
Ala Ser Arg Leu Ala Ser Lys Ser His Gly Ser Val Lys Arg Leu Arg
                485                 490                 495     
Lys Met Ser Val Lys Gly Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu
            500                 505                 510         
Gln Val Ile Lys Asn Tyr Thr Glu Glu Leu Lys Val Pro Pro Asp Glu
        515                 520                 525             
Asp Cys Ile Ile Cys Met Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser
    530                 535                 540                 
Asp Val Thr Asp Ser Lys Ala Ile Gly Ser Leu Ala Val Gly His Leu
545                 550                 555                 560 
Thr Lys Cys Ser His Ala Phe His Leu Leu Cys Leu Leu Ala Met Tyr
                565                 570                 575     
Cys Asn Gly Asn Lys Asp Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr
            580                 585                 590         
Ile Tyr Gly Glu Lys Thr Gly Thr Gln Pro Gln Gly Lys Met Glu Val
        595                 600                 605             
Leu Arg Phe Gln Met Ser Leu Pro Gly His Glu Asp Cys Gly Thr Ile
    610                 615                 620                 
Leu Ile Val Tyr Ser Ile Pro His Gly Ile Gln Gly Pro Glu His Pro
625                 630                 635                 640 
Asn Pro Gly Lys Pro Phe Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr
                645                 650                 655     
Leu Pro Asp Asn Ala Gln Gly Arg Lys Val Leu Glu Leu Leu Lys Val
            660                 665                 670         
Ala Trp Lys Arg Arg Leu Ile Phe Thr Val Gly Thr Ser Ser Thr Thr
        675                 680                 685             
Gly Glu Thr Asp Thr Val Val Trp Asn Glu Ile His His Lys Thr Glu
    690                 695                 700                 
Met Asp Arg Asn Ile Thr Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu
705                 710                 715                 720 
Gln Asn Val Leu Ala Glu Leu Ala Ala Gln Gly Val Thr Glu Asp Cys
                725                 730                 735     
Leu Glu Gln Gln
            740 


<210> 8701
<211> 575
<212> PRT
<213> Homo sapiens

<400> 8701
Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro
 1               5                  10                  15      
Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His
            20                  25                  30          
Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln
        35                  40                  45              
Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro
    50                  55                  60                  
Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro
65                  70                  75                  80  
Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg
                85                  90                  95      
Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp
            100                 105                 110         
Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val
        115                 120                 125             
Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp
    130                 135                 140                 
Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr
145                 150                 155                 160 
Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala
                165                 170                 175     
Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr
            180                 185                 190         
Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly
        195                 200                 205             
Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr
    210                 215                 220                 
Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr
225                 230                 235                 240 
His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg
                245                 250                 255     
Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro
            260                 265                 270         
Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly
        275                 280                 285             
Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala
    290                 295                 300                 
Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr
305                 310                 315                 320 
Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala
                325                 330                 335     
Gly Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn
            340                 345                 350         
Tyr Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys
        355                 360                 365             
Met Glu Lys Leu Ser Ala Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser
    370                 375                 380                 
Lys Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His
385                 390                 395                 400 
Ala Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys
                405                 410                 415     
Asp Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys
            420                 425                 430         
Thr Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met
        435                 440                 445             
Ser Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser
    450                 455                 460                 
Ile Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro
465                 470                 475                 480 
Phe Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala
                485                 490                 495     
Gln Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg
            500                 505                 510         
Leu Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr
        515                 520                 525             
Val Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile
    530                 535                 540                 
Thr Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala
545                 550                 555                 560 
Glu Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln
                565                 570                 575 


<210> 8702
<211> 587
<212> PRT
<213> Homo sapiens

<400> 8702
Met Met Glu Thr Pro Leu Pro Lys Ala Pro Glu Lys Arg Gln Val Thr
 1               5                  10                  15      
Ala Ile Ile Phe Leu Leu Leu Leu Trp Glu Ala Gly Ser Ala Thr Ile
            20                  25                  30          
Lys Tyr Ser Val Leu Glu Glu Arg Asp Ser Gly Ser Phe Val Ala Asn
        35                  40                  45              
Leu Ala Lys Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Ala Arg Gly
    50                  55                  60                  
Ala Arg Ile Leu Ser Lys Gly Asn Lys Gln Tyr Leu Gln Leu Glu Arg
65                  70                  75                  80  
Lys Ser Gly Asn Leu Leu Leu Lys Glu Lys Leu Asp Arg Glu Glu Leu
                85                  90                  95      
Cys Gly Asp Ile Asp Pro Cys Ile Leu His Phe Gln Met Leu Leu Lys
            100                 105                 110         
Asn Pro Val Gln Phe Ile Gln Gly Glu Leu Gln Leu Gln Asp Val Asn
        115                 120                 125             
Asp His Ala Pro Glu Phe Leu Glu Asn Glu Ile Leu Leu Lys Ile Ser
    130                 135                 140                 
Glu Gly Ser His Pro Gly Thr Ser Phe Pro Leu Lys Ile Ala Gln Asp
145                 150                 155                 160 
Leu Asp Val Gly Ser Asn Thr Val Gln Asn Tyr Ser Ile Ser Thr Asn
                165                 170                 175     
Ser Tyr Phe His Leu Phe Thr Arg Asn His Ser Asp Gly Lys Lys Tyr
            180                 185                 190         
Pro Glu Leu Val Leu Asp Gln Ala Leu Asp Arg Glu Glu Gln Pro Gln
        195                 200                 205             
Leu Arg Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Thr
    210                 215                 220                 
Gly Thr Ser Gln Val Leu Ile Val Ile Val Asp Ile Asn Asp Asn Val
225                 230                 235                 240 
Pro Glu Phe Ala Gln Arg Arg Tyr Glu Val Gln Val Pro Glu Asn Thr
                245                 250                 255     
Pro Ile Gly Ser Leu Val Ile Thr Val Ser Ala Arg Asp Leu Asp Ala
            260                 265                 270         
Gly Thr His Gly Glu Leu Ser Tyr Ser Phe Phe Gln Tyr Ser Asn Gln
        275                 280                 285             
Ile Ile Gln Ala Phe Glu Ile Asn Ser Ile Thr Gly Glu Ile Arg Phe
    290                 295                 300                 
Lys Lys Ala Leu Asp Phe Glu Glu Ile Gln Ser Tyr His Met Glu Val
305                 310                 315                 320 
Glu Ala Ser Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Val Ala Ile
                325                 330                 335     
Glu Val Met Asp Ile Asn Asp Asn Ala Pro Glu Leu Thr Met Ser Leu
            340                 345                 350         
Leu Ile Ser Asp Ile Leu Glu Asn Ser Pro Glu Thr Val Val Ala Val
        355                 360                 365             
Phe Gly Ile Ser Asp Pro Asp Ser Gly Asn Asn Gly Lys Met Met Cys
    370                 375                 380                 
Ser Ile Gln Asp His Leu Pro Phe Leu Leu Lys Pro Thr Leu Glu Asn
385                 390                 395                 400 
Phe Tyr Thr Leu Leu Thr Glu Gly Ala Leu Asp Arg Glu Ser Arg Ala
                405                 410                 415     
Glu Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu
            420                 425                 430         
Lys Thr Glu Tyr Asn Ile Thr Leu Arg Val Ser Asp Val Asn Asp Asn
        435                 440                 445             
Ala Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn
    450                 455                 460                 
Asn Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp
465                 470                 475                 480 
Ser Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asn
                485                 490                 495     
Pro His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Thr Asp Asn Gly
            500                 505                 510         
His Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Glu Phe
        515                 520                 525             
Glu Phe Arg Val Gly Ala Ser Asp Arg Gly Ser Pro Ala Leu Ser Ser
    530                 535                 540                 
Glu Ala Leu Val Arg Val Leu Val Cys Trp Thr Pro Thr Thr Thr Arg
545                 550                 555                 560 
Pro Ser Cys Cys Thr Arg Cys Arg Thr Ala Pro Arg Pro Ala Pro Ser
                565                 570                 575     
Trp Cys Pro Gly Arg Pro Ser Arg Ala Thr Trp
            580                 585         


<210> 8703
<211> 692
<212> PRT
<213> Homo sapiens

<400> 8703
Met Glu Leu Leu Pro Leu Trp Leu Cys Leu Gly Phe His Phe Leu Thr
 1               5                  10                  15      
Val Gly Trp Arg Asn Arg Ser Gly Thr Ala Thr Ala Ala Ser Gln Gly
            20                  25                  30          
Val Cys Lys Leu Val Gly Gly Ala Ala Asp Cys Arg Gly Gln Ser Leu
        35                  40                  45              
Ala Ser Val Pro Ser Ser Leu Pro Pro His Ala Arg Met Leu Thr Leu
    50                  55                  60                  
Asp Ala Asn Pro Leu Lys Thr Leu Trp Asn His Ser Leu Gln Pro Tyr
65                  70                  75                  80  
Pro Leu Leu Glu Ser Leu Ser Leu His Ser Cys His Leu Glu Arg Ile
                85                  90                  95      
Ser Arg Gly Ala Phe Gln Glu Gln Gly His Leu Arg Ser Leu Val Leu
            100                 105                 110         
Gly Asp Asn Cys Leu Ser Glu Asn Tyr Glu Glu Thr Ala Ala Ala Leu
        115                 120                 125             
His Ala Leu Pro Gly Leu Arg Arg Leu Asp Leu Ser Gly Asn Ala Leu
    130                 135                 140                 
Thr Glu Asp Met Ala Ala Leu Met Leu Gln Asn Leu Ser Ser Leu Arg
145                 150                 155                 160 
Ser Val Ser Leu Ala Gly Asn Thr Ile Met Arg Leu Asp Asp Ser Val
                165                 170                 175     
Phe Glu Gly Leu Glu Arg Leu Arg Glu Leu Asp Leu Gln Arg Asn Tyr
            180                 185                 190         
Ile Phe Glu Ile Glu Gly Gly Ala Phe Asp Gly Leu Ala Glu Leu Arg
        195                 200                 205             
His Leu Asn Leu Ala Phe Asn Asn Leu Pro Cys Ile Val Asp Phe Gly
    210                 215                 220                 
Leu Thr Arg Leu Arg Val Leu Asn Val Ser Tyr Asn Val Leu Glu Trp
225                 230                 235                 240 
Phe Leu Ala Thr Gly Gly Glu Ala Ala Phe Glu Leu Glu Thr Leu Asp
                245                 250                 255     
Leu Ser His Asn Gln Leu Leu Phe Phe Pro Leu Leu Pro Gln Tyr Ser
            260                 265                 270         
Lys Leu Arg Thr Leu Leu Leu Arg Asp Asn Asn Met Gly Phe Tyr Arg
        275                 280                 285             
Asp Leu Tyr Asn Thr Ser Ser Pro Arg Glu Met Val Ala Gln Phe Leu
    290                 295                 300                 
Leu Val Asp Gly Asn Val Thr Asn Ile Thr Thr Val Ser Leu Trp Glu
305                 310                 315                 320 
Glu Phe Ser Ser Ser Asp Leu Ala Asp Leu Arg Phe Leu Asp Met Ser
                325                 330                 335     
Gln Asn Gln Phe Gln Tyr Leu Pro Asp Gly Phe Leu Arg Lys Met Pro
            340                 345                 350         
Ser Leu Ser His Leu Asn Leu His Gln Asn Cys Leu Met Thr Leu His
        355                 360                 365             
Ile Arg Glu His Glu Pro Pro Gly Ala Leu Thr Glu Leu Asp Leu Ser
    370                 375                 380                 
His Asn Gln Leu Ser Glu Leu His Leu Ala Pro Gly Leu Ala Ser Cys
385                 390                 395                 400 
Leu Gly Ser Leu Arg Leu Phe Asn Leu Ser Ser Asn Gln Leu Leu Gly
                405                 410                 415     
Val Pro Pro Gly Leu Phe Ala Asn Ala Arg Asn Ile Thr Thr Leu Asp
            420                 425                 430         
Met Ser His Asn Gln Ile Ser Leu Cys Pro Leu Pro Ala Ala Ser Asp
        435                 440                 445             
Arg Val Gly Pro Pro Ser Cys Val Asp Phe Arg Asn Met Ala Ser Leu
    450                 455                 460                 
Arg Ser Leu Ser Leu Glu Gly Cys Gly Leu Gly Ala Leu Pro Asp Cys
465                 470                 475                 480 
Pro Phe Gln Gly Thr Ser Leu Thr Tyr Leu Asp Leu Ser Ser Asn Trp
                485                 490                 495     
Gly Val Leu Asn Gly Ser Leu Ala Pro Leu Gln Asp Val Ala Pro Met
            500                 505                 510         
Leu Gln Val Leu Ser Leu Arg Asn Met Gly Leu His Ser Ser Phe Met
        515                 520                 525             
Ala Leu Asp Phe Ser Gly Phe Gly Asn Leu Arg Asp Leu Asp Leu Ser
    530                 535                 540                 
Gly Asn Cys Leu Thr Thr Phe Pro Arg Phe Gly Gly Ser Leu Ala Leu
545                 550                 555                 560 
Glu Thr Leu Asp Leu Arg Arg Asn Ser Leu Thr Ala Leu Pro Gln Lys
                565                 570                 575     
Ala Val Ser Glu Gln Leu Ser Arg Gly Leu Arg Thr Ile Tyr Leu Ser
            580                 585                 590         
Gln Asn Pro Tyr Asp Cys Cys Gly Val Asp Gly Trp Gly Ala Leu Gln
        595                 600                 605             
His Gly Gln Thr Val Ala Asp Trp Ala Met Val Thr Cys Asn Leu Ser
    610                 615                 620                 
Ser Lys Ile Ile Arg Val Thr Glu Leu Pro Gly Gly Val Pro Arg Asp
625                 630                 635                 640 
Cys Lys Trp Glu Arg Leu Asp Leu Gly Leu Leu Tyr Leu Val Leu Ile
                645                 650                 655     
Leu Pro Ser Cys Leu Thr Leu Leu Val Ala Cys Thr Val Ile Val Leu
            660                 665                 670         
Thr Phe Lys Lys Pro Leu Leu Gln Val Ile Lys Ser Arg Cys His Trp
        675                 680                 685             
Ser Ser Val Tyr
    690         


<210> 8704
<211> 517
<212> PRT
<213> Homo sapiens

<400> 8704
Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu
 1               5                  10                  15      
Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro
            20                  25                  30          
Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala
        35                  40                  45              
Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val
    50                  55                  60                  
Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val
65                  70                  75                  80  
Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met
                85                  90                  95      
Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile
            100                 105                 110         
Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly
        115                 120                 125             
Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys
    130                 135                 140                 
Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr
145                 150                 155                 160 
Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val
                165                 170                 175     
Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln
            180                 185                 190         
Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met
        195                 200                 205             
Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu
    210                 215                 220                 
Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly
225                 230                 235                 240 
Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp
                245                 250                 255     
Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val
            260                 265                 270         
Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly
        275                 280                 285             
Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val
    290                 295                 300                 
Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys
305                 310                 315                 320 
Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val
                325                 330                 335     
Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe
            340                 345                 350         
Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys
        355                 360                 365             
Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Glu Gly Ala Lys Leu
    370                 375                 380                 
Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro
385                 390                 395                 400 
Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu
                405                 410                 415     
Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu
            420                 425                 430         
Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val
        435                 440                 445             
Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln
    450                 455                 460                 
Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser
465                 470                 475                 480 
Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu
                485                 490                 495     
Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val
            500                 505                 510         
Pro Gln Lys Asn Ser
        515         


<210> 8705
<211> 158
<212> PRT
<213> Homo sapiens

<400> 8705
Asp Arg Gly Val Val Gly Ala Arg Arg Ser Leu Ala Val Pro Ser Thr
 1               5                  10                  15      
Ser Ala Ala Ala Ser Leu Thr Gly Cys Leu Ala Ala Ala Ser Gly Glu
            20                  25                  30          
Glu Gln Thr Leu Thr Leu Ser Val Arg Lys Met Ser Ala Pro Ala Gln
        35                  40                  45              
Pro Pro Ala Glu Gly Thr Glu Gly Thr Ala Pro Gly Gly Gly Pro Pro
    50                  55                  60                  
Gly Pro Pro Pro Asn Met Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln
65                  70                  75                  80  
Ala Gln Val Glu Glu Val Val Asp Ile Ile Arg Val Asn Val Asp Lys
                85                  90                  95      
Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp
            100                 105                 110         
Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu
        115                 120                 125             
Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Met Ile Met Leu Gly
    130                 135                 140                 
Ala Ile Cys Ala Ile Ile Val Val Val Ile Val Arg Arg Asp
145                 150                 155             


<210> 8706
<211> 248
<212> PRT
<213> Homo sapiens

<400> 8706
Met Ala Leu Cys Glu Ala Ala Gly Cys Gly Ser Ala Leu Leu Trp Pro
 1               5                  10                  15      
Arg Leu Leu Leu Phe Gly Asp Ser Ile Thr Gln Phe Ser Phe Gln Gln
            20                  25                  30          
Gly Gly Trp Gly Ala Ser Leu Ala Asp Arg Leu Val Arg Lys Cys Asp
        35                  40                  45              
Val Leu Asn Arg Gly Phe Ser Gly Tyr Asn Thr Arg Trp Ala Lys Ile
    50                  55                  60                  
Ile Leu Pro Arg Leu Ile Arg Lys Gly Asn Ser Leu Asp Ile Pro Val
65                  70                  75                  80  
Ala Val Thr Ile Phe Phe Gly Ala Asn Asp Ser Ala Leu Lys Asp Glu
                85                  90                  95      
Asn Pro Lys Gln His Ile Pro Leu Glu Glu Tyr Ala Ala Asn Leu Lys
            100                 105                 110         
Ser Met Val Gln Tyr Leu Lys Ser Val Asp Ile Pro Glu Asn Arg Val
        115                 120                 125             
Ile Leu Ile Thr Pro Thr Pro Leu Cys Glu Thr Ala Trp Glu Glu Gln
    130                 135                 140                 
Cys Ile Ile Gln Gly Cys Lys Leu Asn Arg Leu Asn Ser Val Val Gly
145                 150                 155                 160 
Glu Tyr Ala Asn Ala Cys Leu Gln Val Ala Gln Asp Cys Gly Thr Asp
                165                 170                 175     
Val Leu Asp Leu Trp Thr Leu Met Gln Asp Ser Gln Asp Phe Ser Ser
            180                 185                 190         
Tyr Leu Ser Asp Gly Leu His Leu Ser Pro Lys Gly Asn Glu Phe Leu
        195                 200                 205             
Phe Ser His Leu Trp Pro Leu Ile Glu Lys Lys Val Ser Ser Leu Pro
    210                 215                 220                 
Leu Leu Leu Pro Tyr Trp Arg Asp Val Ala Glu Ala Lys Pro Glu Leu
225                 230                 235                 240 
Ser Leu Leu Gly Asp Gly Asp His
                245             


<210> 8707
<211> 903
<212> PRT
<213> Homo sapiens

<400> 8707
Met Ala Ala Val Ala Gly Ser Gly Ala Ala Ala Ala Pro Ser Ser Leu
 1               5                  10                  15      
Leu Leu Val Val Gly Ser Glu Phe Gly Ser Pro Gly Leu Leu Thr Tyr
            20                  25                  30          
Val Leu Glu Glu Leu Glu Arg Gly Ile Arg Ser Trp Asp Val Asp Pro
        35                  40                  45              
Gly Val Cys Asn Leu Asp Glu Gln Leu Lys Val Phe Val Ser Arg His
    50                  55                  60                  
Ser Ala Thr Phe Ser Ser Ile Val Lys Gly Gln Arg Ser Leu His His
65                  70                  75                  80  
Arg Gly Asp Asn Leu Glu Thr Leu Val Leu Leu Asn Pro Ser Asp Lys
                85                  90                  95      
Ser Leu Tyr Asp Glu Leu Arg Asn Leu Leu Leu Asp Pro Ala Ser His
            100                 105                 110         
Lys Leu Leu Val Leu Ala Gly Leu Cys Leu Glu Glu Thr Gly Glu Leu
        115                 120                 125             
Leu Leu Gln Thr Gly Gly Phe Ser Pro His His Phe Leu Gln Val Leu
    130                 135                 140                 
Lys Asp Arg Glu Ile Arg Asp Ile Leu Ala Thr Thr Pro Pro Pro Val
145                 150                 155                 160 
Gln Pro Pro Ile Leu Thr Ile Thr Cys Pro Thr Phe Gly Asp Trp Ala
                165                 170                 175     
Gln Pro Ala Pro Ala Val Pro Gly Leu Gln Gly Ala Leu Arg Leu Gln
            180                 185                 190         
Leu Arg Leu Asn Pro Pro Ala Gln Leu Pro Asn Ser Glu Gly Leu Cys
        195                 200                 205             
Glu Phe Leu Glu Tyr Val Ala Glu Ser Leu Glu Pro Pro Ser Pro Phe
    210                 215                 220                 
Glu Leu Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Arg Leu Gly Arg
225                 230                 235                 240 
Pro Cys Cys Tyr Ile Phe Pro Gly Gly Leu Gly Asp Ala Ala Phe Phe
                245                 250                 255     
Ala Val Asn Gly Phe Thr Val Leu Val Asn Gly Gly Ser Asn Pro Lys
            260                 265                 270         
Ser Ser Phe Trp Lys Leu Val Arg His Leu Asp Arg Val Asp Ala Val
        275                 280                 285             
Leu Val Thr His Pro Gly Ala Asp Ser Leu Pro Gly Leu Asn Ser Leu
    290                 295                 300                 
Leu Arg Arg Lys Leu Ala Glu Arg Ser Glu Val Ala Ala Gly Gly Gly
305                 310                 315                 320 
Ser Trp Asp Asp Arg Leu Arg Arg Leu Ile Ser Pro Asn Leu Gly Val
                325                 330                 335     
Val Phe Phe Asn Ala Cys Glu Ala Ala Ser Arg Leu Ala Arg Gly Glu
            340                 345                 350         
Asp Glu Ala Glu Leu Ala Leu Ser Leu Leu Ala Gln Leu Gly Ile Thr
        355                 360                 365             
Pro Leu Pro Leu Ser Arg Gly Pro Val Pro Ala Lys Pro Thr Val Leu
    370                 375                 380                 
Phe Glu Lys Met Gly Val Gly Arg Leu Asp Met Tyr Val Leu His Pro
385                 390                 395                 400 
Pro Ser Ala Gly Ala Glu Arg Thr Leu Ala Ser Val Cys Ala Leu Leu
                405                 410                 415     
Val Trp His Pro Ala Gly Pro Gly Glu Lys Val Val Arg Val Leu Phe
            420                 425                 430         
Pro Gly Cys Thr Pro Pro Ala Cys Leu Leu Asp Gly Leu Val Arg Leu
        435                 440                 445             
Gln His Leu Arg Phe Leu Arg Glu Pro Val Val Thr Pro Gln Asp Leu
    450                 455                 460                 
Glu Gly Pro Gly Arg Ala Glu Ser Lys Glu Ser Val Gly Ser Arg Asp
465                 470                 475                 480 
Ser Ser Lys Arg Glu Gly Leu Leu Ala Thr His Pro Arg Pro Gly Gln
                485                 490                 495     
Glu Arg Pro Gly Val Ala Arg Lys Glu Pro Ala Arg Ala Glu Ala Pro
            500                 505                 510         
Arg Lys Thr Glu Lys Glu Ala Lys Thr Pro Arg Glu Leu Arg Lys Asp
        515                 520                 525             
Pro Lys Pro Ser Val Ser Arg Thr Gln Pro Arg Glu Val Arg Arg Ala
    530                 535                 540                 
Ala Ser Ser Val Pro Asn Leu Lys Lys Thr Asn Ala Gln Ala Ala Pro
545                 550                 555                 560 
Lys Pro Arg Lys Ala Pro Ser Thr Ser His Ser Gly Phe Pro Pro Val
                565                 570                 575     
Ala Asn Gly Pro Arg Ser Pro Pro Ser Leu Arg Cys Gly Glu Ala Ser
            580                 585                 590         
Pro Pro Ser Ala Ala Cys Gly Ser Pro Ala Ser Gln Leu Val Ala Thr
        595                 600                 605             
Pro Ser Leu Glu Leu Gly Pro Ile Pro Ala Gly Glu Glu Lys Ala Leu
    610                 615                 620                 
Glu Leu Pro Leu Ala Ala Ser Ser Ile Pro Arg Pro Arg Thr Pro Ser
625                 630                 635                 640 
Pro Glu Ser His Arg Ser Pro Ala Glu Gly Ser Glu Arg Leu Ser Leu
                645                 650                 655     
Ser Pro Leu Arg Gly Gly Glu Ala Gly Pro Asp Ala Ser Pro Thr Val
            660                 665                 670         
Thr Thr Pro Thr Val Thr Thr Pro Ser Leu Pro Ala Glu Val Gly Ser
        675                 680                 685             
Pro His Ser Thr Glu Val Asp Glu Ser Leu Ser Val Ser Phe Glu Gln
    690                 695                 700                 
Val Leu Pro Pro Ser Ala Pro Thr Ser Glu Ala Gly Leu Ser Leu Pro
705                 710                 715                 720 
Leu Arg Gly Pro Arg Ala Arg Arg Ser Ala Ser Pro His Asp Val Asp
                725                 730                 735     
Leu Cys Leu Val Ser Pro Cys Glu Phe Glu His Arg Lys Ala Val Pro
            740                 745                 750         
Met Ala Pro Ala Pro Ala Ser Pro Gly Ser Ser Asn Asp Ser Ser Ala
        755                 760                 765             
Arg Ser Gln Glu Arg Ala Gly Gly Leu Gly Ala Glu Glu Thr Pro Pro
    770                 775                 780                 
Thr Ser Val Ser Glu Ser Leu Pro Thr Leu Ser Asp Ser Asp Pro Val
785                 790                 795                 800 
Pro Leu Ala Pro Gly Ala Ala Asp Ser Asp Glu Asp Thr Glu Gly Phe
                805                 810                 815     
Gly Val Pro Arg His Asp Pro Leu Pro Asp Pro Leu Lys Val Pro Pro
            820                 825                 830         
Pro Leu Pro Asp Pro Ser Ser Ile Cys Met Val Asp Pro Glu Met Leu
        835                 840                 845             
Pro Pro Gln Asp Ser Thr Ala Asn Gly Glu Arg Gln Pro His Pro Glu
    850                 855                 860                 
Ala Pro Gly Pro Pro Gln Leu Thr Arg Cys Arg Pro Gln Ser His Ser
865                 870                 875                 880 
Ser Gly Cys Cys Gln Asn Gln Gly Ala Cys Trp Trp Gly Pro Cys Gln
                885                 890                 895     
Pro Thr Thr Gln Cys Pro Glu
            900             


<210> 8708
<211> 511
<212> PRT
<213> Homo sapiens

<400> 8708
Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg
 1               5                  10                  15      
Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala
            20                  25                  30          
Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn
        35                  40                  45              
Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn
    50                  55                  60                  
Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys
65                  70                  75                  80  
Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe
                85                  90                  95      
Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu
            100                 105                 110         
Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Gly
        115                 120                 125             
Ala Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr
    130                 135                 140                 
Gly Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn
145                 150                 155                 160 
Arg Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val
                165                 170                 175     
His Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe
            180                 185                 190         
Pro Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu
        195                 200                 205             
Leu Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys
    210                 215                 220                 
Glu Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala
225                 230                 235                 240 
Val Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val
                245                 250                 255     
Lys Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu
            260                 265                 270         
Leu Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile
        275                 280                 285             
Gly Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu
    290                 295                 300                 
Pro Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp
305                 310                 315                 320 
Ala Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu
                325                 330                 335     
Met Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser
            340                 345                 350         
Gly Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile
        355                 360                 365             
Met Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val
    370                 375                 380                 
Ala Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser
385                 390                 395                 400 
Asn Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn
                405                 410                 415     
Val Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr
            420                 425                 430         
Glu Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys
        435                 440                 445             
Leu Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile
    450                 455                 460                 
Gly Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly
465                 470                 475                 480 
Ser Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu
                485                 490                 495     
Gln Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys
            500                 505                 510     


<210> 8709
<211> 113
<212> PRT
<213> Homo sapiens

<400> 8709
Met Asn Phe Tyr Leu Leu Leu Ala Ser Ser Ile Leu Cys Ala Leu Ile
 1               5                  10                  15      
Val Phe Trp Lys Tyr Arg Arg Phe Gln Arg Asn Thr Gly Glu Met Ser
            20                  25                  30          
Ser Asn Ser Thr Ala Leu Ala Leu Val Arg Pro Ser Ser Ser Gly Leu
        35                  40                  45              
Ile Asn Ser Asn Thr Asp Asn Asn Leu Ala Val Tyr Asp Leu Ser Arg
    50                  55                  60                  
Asp Ile Leu Asn Asn Phe Pro His Ser Ile Ala Arg Gln Lys Arg Ile
65                  70                  75                  80  
Leu Val Asn Leu Ser Met Val Glu Asn Lys Leu Val Glu Leu Glu His
                85                  90                  95      
Thr Leu Leu Ser Lys Gly Phe Arg Gly Ala Ser Pro His Arg Lys Ser
            100                 105                 110         
Thr
    


<210> 8710
<211> 283
<212> PRT
<213> Homo sapiens

<400> 8710
Met Gln Thr Asp Ser Leu Ser Pro Ser Pro Asn Pro Val Ser Pro Val
 1               5                  10                  15      
Pro Leu Asn Asn Pro Thr Ser Ala Pro Arg Tyr Gly Thr Val Ile Pro
            20                  25                  30          
Asn Arg Ile Phe Val Gly Gly Ile Asp Phe Lys Thr Asn Glu Ser Asp
        35                  40                  45              
Leu Arg Lys Phe Phe Ser Gln Tyr Gly Ser Val Lys Glu Val Lys Ile
    50                  55                  60                  
Val Asn Asp Arg Ala Gly Val Ser Lys Gly Tyr Gly Phe Val Thr Phe
65                  70                  75                  80  
Glu Thr Gln Glu Asp Ala Gln Lys Ile Leu Gln Glu Ala Glu Lys Leu
                85                  90                  95      
Asn Tyr Lys Asp Lys Lys Leu Asn Ile Gly Pro Ala Ile Arg Lys Gln
            100                 105                 110         
Gln Val Gly Ile Pro Arg Ser Ser Ile Met Pro Ala Ala Gly Thr Met
        115                 120                 125             
Tyr Leu Thr Thr Ser Thr Gly Tyr Pro Tyr Thr Tyr His Asn Gly Val
    130                 135                 140                 
Ala Tyr Phe His Thr Pro Glu Val Thr Ser Val Pro Pro Pro Trp Pro
145                 150                 155                 160 
Ser Arg Ser Val Cys Ser Ser Pro Val Met Val Ala Gln Pro Ile Tyr
                165                 170                 175     
Gln Gln Pro Ala Tyr His Tyr Gln Ala Thr Thr Gln Tyr Leu Pro Gly
            180                 185                 190         
Gln Trp Gln Trp Ser Val Pro Gln Pro Ser Ala Ser Ser Ala Pro Phe
        195                 200                 205             
Leu Tyr Leu Gln Pro Ser Glu Val Ile Tyr Gln Pro Val Glu Ile Ala
    210                 215                 220                 
Gln Asp Gly Gly Cys Val Pro Pro Pro Leu Ser Leu Met Glu Thr Ser
225                 230                 235                 240 
Val Pro Glu Pro Tyr Ser Asp His Gly Val Gln Ala Thr Tyr His Gln
                245                 250                 255     
Val Tyr Ala Pro Ser Ala Ile Thr Met Pro Ala Pro Val Met Gln Pro
            260                 265                 270         
Glu Pro Ile Lys Thr Val Trp Ser Ile His Tyr
        275                 280             


<210> 8711
<211> 382
<212> PRT
<213> Homo sapiens

<400> 8711
Ala Leu Leu Leu Leu Thr Leu Lys Tyr Phe Val Gly Leu Ala Arg Trp
 1               5                  10                  15      
Leu Pro Pro Val Ile Pro Ala Leu Trp Glu Ala Lys Val Gly Gly Ser
            20                  25                  30          
Arg Gly Gln Glu Ile Glu Thr Ile Leu Ala Lys Met Gln Thr Ser Asn
        35                  40                  45              
Gln Met Gln Thr Asp Ser Leu Ser Pro Ser Pro Asn Pro Val Ser Pro
    50                  55                  60                  
Val Pro Leu Asn Asn Pro Thr Ser Ala Pro Arg Tyr Gly Thr Val Ile
65                  70                  75                  80  
Pro Asn Arg Ile Phe Val Gly Gly Ile Asp Phe Lys Thr Asn Glu Ser
                85                  90                  95      
Asp Leu Arg Lys Phe Phe Ser Gln Tyr Gly Ser Val Lys Glu Val Lys
            100                 105                 110         
Ile Val Asn Asp Arg Ala Gly Val Ser Lys Gly Tyr Gly Phe Val Thr
        115                 120                 125             
Phe Glu Thr Gln Glu Asp Ala Gln Lys Ile Leu Gln Glu Ala Glu Lys
    130                 135                 140                 
Leu Asn Tyr Lys Asp Lys Lys Leu Asn Ile Gly Pro Ala Ile Arg Lys
145                 150                 155                 160 
Gln Gln Val Gly Ile Pro Arg Ser Ser Ile Met Pro Ala Ala Gly Thr
                165                 170                 175     
Met Tyr Leu Thr Thr Ser Thr Gly Tyr Pro Tyr Thr Tyr His Asn Gly
            180                 185                 190         
Val Ala Tyr Phe His Thr Pro Glu Val Thr Ser Val Pro Pro Pro Trp
        195                 200                 205             
Pro Ser Arg Ser Val Cys Ser Ser Pro Val Met Val Ala Gln Pro Ile
    210                 215                 220                 
Tyr Gln Gln Pro Ala Tyr His Tyr Gln Gly Ile Lys Gln Cys His Thr
225                 230                 235                 240 
Arg Arg Trp Met Asp Ser Leu Leu Pro Phe Thr Lys Cys Asp Glu Ala
                245                 250                 255     
Thr Thr Gln Tyr Leu Pro Gly Gln Trp Gln Trp Ser Val Pro Gln Pro
            260                 265                 270         
Ser Ala Ser Ser Ala Pro Phe Leu Tyr Leu Gln Pro Ser Glu Val Ile
        275                 280                 285             
Tyr Gln Pro Val Glu Ile Ala Gln Asp Gly Gly Cys Val Pro Pro Pro
    290                 295                 300                 
Leu Ser Leu Met Glu Thr Ser Val Pro Glu Pro Tyr Ser Asp His Gly
305                 310                 315                 320 
Val Gln Ala Thr Tyr His Gln Val Tyr Ala Pro Ser Ala Ile Thr Met
                325                 330                 335     
Pro Ala Pro Val Met Gln Pro Glu Pro Ile Lys Cys Gly Ala Phe Ile
            340                 345                 350         
Ile Lys Thr Ile Gly Gln Leu Tyr Ser Ser Ser Thr Asp Phe Leu Ser
        355                 360                 365             
Asn Asp Pro Cys Val Ala Glu Ile Gln Leu Gln Arg Thr Ser
    370                 375                 380         


<210> 8712
<211> 295
<212> PRT
<213> Homo sapiens

<400> 8712
Met Glu Thr Glu Ser Gly Pro Gln Thr Ser Asn Gln Met Gln Thr Asp
 1               5                  10                  15      
Ser Leu Ser Pro Ser Pro Asn Pro Val Ser Pro Val Pro Leu Asn Asn
            20                  25                  30          
Pro Thr Ser Ala Pro Arg Tyr Gly Thr Val Ile Pro Asn Arg Ile Phe
        35                  40                  45              
Val Gly Gly Ile Asp Phe Lys Thr Asn Glu Ser Asp Leu Arg Lys Phe
    50                  55                  60                  
Phe Ser Gln Tyr Gly Ser Val Lys Glu Val Lys Ile Val Asn Asp Arg
65                  70                  75                  80  
Ala Gly Val Ser Lys Gly Tyr Gly Phe Val Thr Phe Glu Thr Gln Glu
                85                  90                  95      
Asp Ala Gln Lys Ile Leu Gln Glu Ala Glu Lys Leu Asn Tyr Lys Asp
            100                 105                 110         
Lys Lys Leu Asn Ile Gly Pro Ala Ile Arg Lys Gln Gln Val Gly Ile
        115                 120                 125             
Pro Arg Ser Ser Ile Met Pro Ala Ala Gly Thr Met Tyr Leu Thr Thr
    130                 135                 140                 
Ser Thr Gly Tyr Pro Tyr Thr Tyr His Asn Gly Val Ala Tyr Phe His
145                 150                 155                 160 
Thr Pro Glu Val Thr Ser Val Pro Pro Pro Trp Pro Ser Arg Ser Val
                165                 170                 175     
Cys Ser Ser Pro Val Met Val Ala Gln Pro Ile Tyr Gln Gln Pro Ala
            180                 185                 190         
Tyr His Tyr Gln Ala Thr Thr Gln Tyr Leu Pro Gly Gln Trp Gln Trp
        195                 200                 205             
Ser Val Pro Gln Pro Ser Ala Ser Ser Ala Pro Phe Leu Tyr Leu Gln
    210                 215                 220                 
Pro Ser Glu Val Ile Tyr Gln Pro Val Glu Ile Ala Gln Asp Gly Gly
225                 230                 235                 240 
Cys Val Pro Pro Pro Leu Ser Leu Met Glu Thr Ser Val Pro Glu Pro
                245                 250                 255     
Tyr Ser Asp His Gly Val Gln Ala Thr Tyr His Gln Val Tyr Ala Pro
            260                 265                 270         
Ser Ala Ile Thr Met Pro Ala Pro Val Met Gln Pro Glu Pro Ile Lys
        275                 280                 285             
Thr Val Trp Ser Ile His Tyr
    290                 295 


<210> 8713
<211> 550
<212> PRT
<213> Homo sapiens

<400> 8713
Met Val Thr Ala Ala Met Leu Leu Gln Cys Cys Pro Val Leu Ala Arg
 1               5                  10                  15      
Gly Pro Thr Ser Leu Leu Gly Lys Val Val Lys Thr His Gln Phe Leu
            20                  25                  30          
Phe Gly Ile Gly Arg Cys Pro Ile Leu Ala Thr Gln Gly Pro Asn Cys
        35                  40                  45              
Ser Gln Ile His Leu Lys Ala Thr Lys Ala Gly Gly Asp Ser Pro Ser
    50                  55                  60                  
Trp Ala Lys Gly His Cys Pro Phe Met Leu Ser Glu Leu Gln Asp Gly
65                  70                  75                  80  
Lys Ser Lys Ile Val Gln Lys Ala Ala Pro Glu Val Gln Glu Asp Val
                85                  90                  95      
Lys Ala Phe Lys Thr Gly Asn Tyr Val Phe Ser Tyr Asp Gln Phe Phe
            100                 105                 110         
Arg Asp Lys Ile Met Glu Lys Lys Gln Asp His Thr Tyr Arg Val Phe
        115                 120                 125             
Lys Thr Val Asn Arg Trp Ala Asp Ala Tyr Pro Phe Ala Gln His Phe
    130                 135                 140                 
Ser Glu Ala Ser Val Ala Ser Lys Asp Val Ser Val Trp Cys Ser Asn
145                 150                 155                 160 
Asp Tyr Leu Gly Met Ser Arg His Pro Gln Val Leu Gln Ala Thr Gln
                165                 170                 175     
Glu Thr Leu Gln Arg His Gly Val Gly Ala Gly Gly Thr Arg Asn Ile
            180                 185                 190         
Ser Gly Thr Ser Lys Phe His Val Glu Leu Glu Gln Glu Leu Ala Glu
        195                 200                 205             
Leu His Gln Lys Asp Ser Ala Leu Leu Phe Ser Ser Cys Phe Val Ala
    210                 215                 220                 
Asn Asp Ser Thr Leu Phe Thr Leu Ala Lys Ile Leu Pro Gly Cys Glu
225                 230                 235                 240 
Ile Tyr Ser Asp Ala Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg
                245                 250                 255     
Asn Ser Gly Ala Ala Lys Phe Val Phe Arg His Asn Asp Pro Asp His
            260                 265                 270         
Leu Lys Lys Leu Leu Glu Lys Ser Asn Pro Lys Ile Pro Lys Ile Val
        275                 280                 285             
Ala Phe Glu Thr Val His Ser Met Asp Gly Ala Ile Cys Pro Leu Glu
    290                 295                 300                 
Glu Leu Cys Asp Val Ser His Gln Tyr Gly Ala Leu Thr Phe Val Asp
305                 310                 315                 320 
Glu Val His Ala Val Gly Leu Tyr Gly Ser Arg Gly Ala Gly Ile Gly
                325                 330                 335     
Glu Arg Asp Gly Ile Met His Lys Ile Asp Ile Ile Ser Gly Thr Leu
            340                 345                 350         
Gly Lys Ala Phe Gly Cys Val Gly Gly Tyr Ile Ala Ser Thr Arg Asp
        355                 360                 365             
Leu Val Asp Met Val Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr
    370                 375                 380                 
Ser Leu Pro Pro Met Val Leu Ser Gly Ala Leu Glu Ser Val Arg Leu
385                 390                 395                 400 
Leu Lys Gly Glu Glu Gly Gln Ala Leu Arg Arg Ala His Gln Arg Asn
                405                 410                 415     
Val Lys His Met Arg Gln Leu Leu Met Asp Arg Gly Leu Pro Val Ile
            420                 425                 430         
Pro Cys Pro Ser His Ile Ile Pro Ile Arg Val Gly Asn Ala Ala Leu
        435                 440                 445             
Asn Ser Lys Leu Cys Asp Leu Leu Leu Ser Lys His Gly Ile Tyr Val
    450                 455                 460                 
Gln Ala Ile Asn Tyr Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg
465                 470                 475                 480 
Leu Ala Pro Ser Pro His His Ser Pro Gln Met Met Glu Asp Phe Val
                485                 490                 495     
Glu Lys Leu Leu Leu Ala Trp Thr Ala Val Gly Leu Pro Leu Gln Asp
            500                 505                 510         
Val Ser Val Ala Ala Cys Asn Phe Cys Arg Arg Pro Val His Phe Glu
        515                 520                 525             
Leu Met Ser Glu Trp Glu Arg Ser Tyr Phe Gly Asn Met Gly Pro Gln
    530                 535                 540                 
Tyr Val Thr Thr Tyr Ala
545                 550 


<210> 8714
<211> 1200
<212> PRT
<213> Homo sapiens

<400> 8714
Met Lys Val Ala Gly Gly Leu Glu Leu Gly Ala Ala Ala Leu Leu Ser
 1               5                  10                  15      
Ala Ser Pro Arg Ala Leu Val Thr Leu Ser Thr Gly Pro Thr Cys Ser
            20                  25                  30          
Ile Leu Pro Lys Asn Pro Leu Phe Pro Gln Asn Leu Ser Ser Gln Pro
        35                  40                  45              
Cys Ile Lys Met Glu Gly Asp Lys Ser Leu Thr Phe Ser Ser Tyr Gly
    50                  55                  60                  
Leu Gln Trp Cys Leu Tyr Glu Leu Asp Lys Glu Glu Phe Gln Thr Phe
65                  70                  75                  80  
Lys Glu Leu Leu Lys Lys Lys Ser Ser Glu Ser Thr Thr Cys Ser Ile
                85                  90                  95      
Pro Gln Phe Glu Ile Glu Asn Ala Asn Val Glu Cys Leu Ala Leu Leu
            100                 105                 110         
Leu His Glu Tyr Tyr Gly Ala Ser Leu Ala Trp Ala Thr Ser Ile Ser
        115                 120                 125             
Ile Phe Glu Asn Met Asn Leu Arg Thr Leu Ser Glu Lys Ala Arg Asp
    130                 135                 140                 
Asp Met Lys Arg His Ser Pro Glu Asp Pro Glu Ala Thr Met Thr Asp
145                 150                 155                 160 
Gln Gly Pro Ser Lys Glu Lys Val Pro Gly Ile Ser Gln Ala Val Gln
                165                 170                 175     
Gln Asp Ser Ala Thr Ala Ala Glu Thr Lys Glu Gln Glu Ile Ser Gln
            180                 185                 190         
Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu Glu Gln Glu
        195                 200                 205             
Ile Ser Gln Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu
    210                 215                 220                 
Glu Gln Gly His Gly Gly Asp Thr Trp Asp Tyr Lys Ser His Val Met
225                 230                 235                 240 
Thr Lys Phe Ala Glu Glu Glu Asp Val Arg Arg Ser Phe Glu Asn Thr
                245                 250                 255     
Ala Ala Asp Trp Pro Glu Met Gln Thr Leu Ala Gly Ala Phe Asp Ser
            260                 265                 270         
Asp Arg Trp Gly Phe Arg Pro Arg Thr Val Val Leu His Gly Lys Ser
        275                 280                 285             
Gly Ile Gly Lys Ser Ala Leu Ala Arg Arg Ile Val Leu Cys Trp Ala
    290                 295                 300                 
Gln Gly Gly Leu Tyr Gln Gly Met Phe Ser Tyr Val Phe Phe Leu Pro
305                 310                 315                 320 
Val Arg Glu Met Gln Arg Lys Lys Glu Ser Ser Val Thr Glu Phe Ile
                325                 330                 335     
Ser Arg Glu Trp Pro Asp Ser Gln Ala Pro Val Thr Glu Ile Met Ser
            340                 345                 350         
Arg Pro Glu Arg Leu Leu Phe Ile Ile Asp Gly Phe Asp Asp Leu Gly
        355                 360                 365             
Ser Val Leu Asn Asn Asp Thr Lys Leu Cys Lys Asp Trp Ala Glu Lys
    370                 375                 380                 
Gln Pro Pro Phe Thr Leu Ile Arg Ser Leu Leu Arg Lys Val Leu Leu
385                 390                 395                 400 
Pro Glu Ser Phe Leu Ile Val Thr Val Arg Asp Val Gly Thr Glu Lys
                405                 410                 415     
Leu Lys Ser Glu Val Val Ser Pro Arg Tyr Leu Leu Val Arg Gly Ile
            420                 425                 430         
Ser Gly Glu Gln Arg Ile His Leu Leu Leu Glu Arg Gly Ile Gly Glu
        435                 440                 445             
His Gln Lys Thr Gln Gly Leu Arg Ala Ile Met Asn Asn Arg Glu Leu
    450                 455                 460                 
Leu Asp Gln Cys Gln Val Pro Ala Val Gly Ser Leu Ile Cys Val Ala
465                 470                 475                 480 
Leu Gln Leu Gln Asp Val Val Gly Glu Ser Val Ala Pro Phe Asn Gln
                485                 490                 495     
Thr Leu Thr Gly Leu His Ala Ala Phe Val Phe His Gln Leu Thr Pro
            500                 505                 510         
Arg Gly Val Val Arg Arg Cys Leu Asn Leu Glu Glu Arg Val Val Leu
        515                 520                 525             
Lys Arg Phe Cys Arg Met Ala Val Glu Gly Val Trp Asn Arg Lys Ser
    530                 535                 540                 
Val Phe Asp Gly Asp Asp Leu Met Val Gln Gly Leu Gly Glu Ser Glu
545                 550                 555                 560 
Leu Arg Ala Leu Phe His Met Asn Ile Leu Leu Pro Asp Ser His Cys
                565                 570                 575     
Glu Glu Tyr Tyr Thr Phe Phe His Leu Ser Leu Gln Asp Phe Cys Ala
            580                 585                 590         
Ala Leu Tyr Tyr Val Leu Glu Gly Leu Glu Ile Glu Pro Ala Leu Cys
        595                 600                 605             
Pro Leu Tyr Val Glu Lys Thr Lys Arg Ser Met Glu Leu Lys Gln Ala
    610                 615                 620                 
Gly Phe His Ile His Ser Leu Trp Met Lys Arg Phe Leu Phe Gly Leu
625                 630                 635                 640 
Val Ser Glu Asp Val Arg Arg Pro Leu Glu Val Leu Leu Gly Cys Pro
                645                 650                 655     
Val Pro Leu Gly Val Lys Gln Lys Leu Leu His Trp Val Ser Leu Leu
            660                 665                 670         
Gly Gln Gln Pro Asn Ala Thr Thr Pro Gly Asp Thr Leu Asp Ala Phe
        675                 680                 685             
His Cys Leu Phe Glu Thr Gln Asp Lys Glu Phe Val Arg Leu Ala Leu
    690                 695                 700                 
Asn Ser Phe Gln Glu Val Trp Leu Pro Ile Asn Gln Asn Leu Asp Leu
705                 710                 715                 720 
Ile Ala Ser Ser Phe Cys Leu Gln His Cys Pro Tyr Leu Arg Lys Ile
                725                 730                 735     
Arg Val Asp Val Lys Gly Ile Phe Pro Arg Asp Glu Ser Ala Glu Ala
            740                 745                 750         
Cys Pro Val Val Pro Leu Trp Met Arg Asp Lys Thr Leu Ile Glu Glu
        755                 760                 765             
Gln Trp Glu Asp Phe Cys Ser Met Leu Gly Thr His Pro His Leu Arg
    770                 775                 780                 
Gln Leu Asp Leu Gly Ser Ser Ile Leu Thr Glu Arg Ala Met Lys Thr
785                 790                 795                 800 
Leu Cys Ala Lys Leu Arg His Pro Thr Cys Lys Ile Gln Thr Leu Met
                805                 810                 815     
Phe Arg Asn Ala Gln Ile Thr Pro Gly Val Gln His Leu Trp Arg Ile
            820                 825                 830         
Val Met Ala Asn Arg Asn Leu Arg Ser Leu Asn Leu Gly Gly Thr His
        835                 840                 845             
Leu Lys Glu Glu Asp Val Arg Met Ala Cys Glu Ala Leu Lys His Pro
    850                 855                 860                 
Lys Cys Leu Leu Glu Ser Leu Arg Leu Asp Cys Cys Gly Leu Thr His
865                 870                 875                 880 
Ala Cys Tyr Leu Lys Ile Ser Gln Ile Leu Thr Thr Ser Pro Ser Leu
                885                 890                 895     
Lys Ser Leu Ser Leu Ala Gly Asn Lys Val Thr Asp Gln Gly Val Met
            900                 905                 910         
Pro Leu Ser Asp Ala Leu Arg Val Ser Gln Cys Ala Leu Gln Lys Leu
        915                 920                 925             
Ile Leu Glu Asp Cys Gly Ile Thr Ala Thr Gly Cys Gln Ser Leu Ala
    930                 935                 940                 
Ser Ala Leu Val Ser Asn Arg Ser Leu Thr His Leu Cys Leu Ser Asn
945                 950                 955                 960 
Asn Ser Leu Gly Asn Glu Gly Val Asn Leu Leu Cys Arg Ser Met Arg
                965                 970                 975     
Leu Pro His Cys Ser Leu Gln Arg Leu Met Leu Asn Gln Cys His Leu
            980                 985                 990         
Asp Thr Ala Gly Cys Gly Phe Leu Ala Leu Ala Leu Met Gly Asn Ser
        995                 1000                1005            
Trp Leu Thr His Leu Ser Leu Ser Met Asn Pro Val Glu Asp Asn Gly
    1010                1015                1020                
Val Lys Leu Leu Cys Glu Val Met Arg Glu Pro Ser Cys His Leu Gln
1025                1030                1035                1040
Asp Leu Glu Leu Val Lys Cys His Leu Thr Ala Ala Cys Cys Glu Ser
                1045                1050                1055    
Leu Ser Cys Val Ile Ser Arg Ser Arg His Leu Lys Ser Leu Asp Leu
            1060                1065                1070        
Thr Asp Asn Ala Leu Gly Asp Gly Gly Val Ala Ala Leu Cys Glu Gly
        1075                1080                1085            
Leu Lys Gln Lys Asn Ser Val Leu Thr Arg Leu Gly Leu Lys Ala Cys
    1090                1095                1100                
Gly Leu Thr Ser Asp Cys Cys Glu Ala Leu Ser Leu Ala Leu Ser Cys
1105                1110                1115                1120
Asn Arg His Leu Thr Ser Leu Asn Leu Val Gln Asn Asn Phe Ser Pro
                1125                1130                1135    
Lys Gly Met Met Lys Leu Cys Ser Ala Phe Ala Cys Pro Thr Ser Asn
            1140                1145                1150        
Leu Gln Ile Ile Gly Leu Trp Lys Trp Gln Tyr Pro Val Gln Ile Arg
        1155                1160                1165            
Lys Leu Leu Glu Glu Val Gln Leu Leu Lys Pro Arg Val Val Ile Asp
    1170                1175                1180                
Gly Ser Trp His Ser Phe Asp Glu Asp Asp Arg Tyr Trp Trp Lys Asn
1185                1190                1195                1200


<210> 8715
<211> 1200
<212> PRT
<213> Homo sapiens

<400> 8715
Met Lys Val Ala Gly Gly Leu Glu Leu Gly Ala Ala Ala Leu Leu Ser
 1               5                  10                  15      
Ala Ser Pro Arg Ala Leu Val Thr Leu Ser Thr Gly Pro Thr Cys Ser
            20                  25                  30          
Ile Leu Pro Lys Asn Pro Leu Phe Pro Gln Asn Leu Ser Ser Gln Pro
        35                  40                  45              
Cys Ile Lys Met Glu Gly Asp Lys Ser Leu Thr Phe Ser Ser Tyr Gly
    50                  55                  60                  
Leu Gln Trp Cys Leu Tyr Glu Leu Asp Lys Glu Glu Phe Gln Thr Phe
65                  70                  75                  80  
Lys Glu Leu Leu Lys Lys Lys Ser Ser Glu Ser Thr Thr Cys Ser Ile
                85                  90                  95      
Pro Gln Phe Glu Ile Glu Asn Ala Asn Val Glu Cys Leu Ala Leu Leu
            100                 105                 110         
Leu His Glu Tyr Tyr Gly Ala Ser Leu Ala Trp Ala Thr Ser Ile Ser
        115                 120                 125             
Ile Phe Glu Asn Met Asn Leu Arg Thr Leu Ser Glu Lys Ala Arg Asp
    130                 135                 140                 
Asp Met Lys Arg His Ser Pro Glu Asp Pro Glu Ala Thr Met Thr Asp
145                 150                 155                 160 
Gln Gly Pro Ser Lys Glu Lys Val Pro Gly Ile Ser Gln Ala Val Gln
                165                 170                 175     
Gln Asp Ser Ala Thr Ala Ala Glu Thr Lys Glu Gln Glu Ile Ser Gln
            180                 185                 190         
Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu Glu Gln Glu
        195                 200                 205             
Ile Ser Gln Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu
    210                 215                 220                 
Glu Gln Gly His Gly Gly Asp Thr Trp Asp Tyr Lys Ser His Val Met
225                 230                 235                 240 
Thr Lys Phe Ala Glu Glu Glu Asp Val Arg Arg Ser Phe Glu Asn Thr
                245                 250                 255     
Ala Ala Asp Trp Pro Glu Met Gln Thr Leu Ala Gly Ala Phe Asp Ser
            260                 265                 270         
Asp Arg Trp Gly Phe Arg Pro Arg Thr Val Val Leu His Gly Lys Ser
        275                 280                 285             
Gly Ile Gly Lys Ser Ala Leu Ala Arg Arg Ile Val Leu Cys Trp Ala
    290                 295                 300                 
Gln Gly Gly Leu Tyr Gln Gly Met Phe Ser Tyr Val Phe Phe Leu Pro
305                 310                 315                 320 
Val Arg Glu Met Gln Arg Lys Lys Glu Ser Ser Val Thr Glu Phe Ile
                325                 330                 335     
Ser Arg Glu Trp Pro Asp Ser Gln Ala Pro Val Thr Glu Ile Met Ser
            340                 345                 350         
Arg Pro Glu Arg Leu Leu Phe Ile Ile Asp Gly Phe Asp Asp Leu Gly
        355                 360                 365             
Ser Val Leu Asn Asn Asp Thr Lys Leu Cys Lys Asp Trp Ala Glu Lys
    370                 375                 380                 
Gln Pro Pro Phe Thr Leu Ile Arg Ser Leu Leu Arg Lys Val Leu Leu
385                 390                 395                 400 
Pro Glu Ser Phe Leu Ile Val Thr Val Arg Asp Val Gly Thr Glu Lys
                405                 410                 415     
Leu Lys Ser Glu Val Val Ser Pro Arg Tyr Leu Leu Val Arg Gly Ile
            420                 425                 430         
Ser Gly Glu Gln Arg Ile His Leu Leu Leu Glu Arg Gly Ile Gly Glu
        435                 440                 445             
His Gln Lys Thr Gln Gly Leu Arg Ala Ile Ile Asn Asn Arg Glu Leu
    450                 455                 460                 
Leu Asp Gln Cys Gln Val Pro Ala Val Gly Ser Leu Ile Cys Val Ala
465                 470                 475                 480 
Leu Gln Leu Gln Asp Val Val Gly Glu Ser Val Ala Pro Phe Asn Gln
                485                 490                 495     
Thr Leu Thr Gly Leu His Ala Ala Phe Ala Phe His Gln Leu Thr Pro
            500                 505                 510         
Arg Gly Val Val Arg Arg Cys Leu Asn Leu Glu Glu Arg Val Val Leu
        515                 520                 525             
Lys Arg Phe Cys Arg Met Ala Val Glu Gly Val Trp Asn Arg Lys Ser
    530                 535                 540                 
Val Phe Asp Gly Asp Asp Leu Met Val Gln Gly Leu Gly Glu Ser Glu
545                 550                 555                 560 
Leu Arg Ala Leu Phe His Met Asn Ile Leu Leu Pro Asp Ser His Cys
                565                 570                 575     
Glu Glu Tyr Tyr Thr Phe Phe His Leu Ser Leu Gln Asp Phe Cys Ala
            580                 585                 590         
Ala Leu Tyr Tyr Val Leu Glu Gly Leu Glu Ile Glu Pro Ala Leu Cys
        595                 600                 605             
Pro Leu Tyr Val Glu Lys Thr Lys Arg Ser Met Glu Leu Lys Gln Ala
    610                 615                 620                 
Gly Phe His Ile His Ser Leu Trp Met Lys Arg Phe Leu Phe Gly Leu
625                 630                 635                 640 
Val Ser Glu Asp Val Arg Arg Pro Leu Glu Val Leu Leu Gly Cys Pro
                645                 650                 655     
Val Pro Leu Gly Val Lys Gln Lys Leu Leu His Trp Val Ser Leu Leu
            660                 665                 670         
Gly Gln Gln Pro Asn Ala Thr Thr Pro Gly Asp Thr Leu Asp Ala Phe
        675                 680                 685             
His Cys Leu Phe Glu Thr Gln Asp Lys Glu Phe Val Arg Leu Ala Leu
    690                 695                 700                 
Asn Ser Phe Gln Glu Val Trp Leu Pro Ile Asn Gln Asn Leu Asp Leu
705                 710                 715                 720 
Ile Ala Ser Ser Phe Cys Leu Gln His Cys Pro Tyr Leu Arg Lys Ile
                725                 730                 735     
Arg Val Asp Val Lys Gly Ile Phe Pro Arg Asp Glu Ser Ala Glu Ala
            740                 745                 750         
Cys Pro Val Val Pro Leu Trp Met Arg Asp Lys Thr Leu Ile Glu Glu
        755                 760                 765             
Gln Trp Glu Asp Phe Cys Ser Met Leu Gly Thr His Pro His Leu Arg
    770                 775                 780                 
Gln Leu Asp Leu Gly Ser Ser Ile Leu Thr Glu Arg Ala Met Lys Thr
785                 790                 795                 800 
Leu Cys Ala Lys Leu Arg His Pro Thr Cys Lys Ile Gln Thr Leu Met
                805                 810                 815     
Phe Arg Asn Ala Gln Ile Thr Pro Gly Val Gln His Leu Trp Arg Ile
            820                 825                 830         
Val Met Ala Asn Arg Asn Leu Arg Ser Leu Asn Leu Gly Gly Thr His
        835                 840                 845             
Leu Lys Glu Glu Asp Val Arg Met Ala Cys Glu Ala Leu Lys His Pro
    850                 855                 860                 
Lys Cys Leu Leu Glu Ser Leu Arg Leu Asp Cys Cys Gly Leu Thr His
865                 870                 875                 880 
Ala Cys Tyr Leu Lys Ile Ser Gln Ile Leu Thr Thr Ser Pro Ser Leu
                885                 890                 895     
Lys Ser Leu Ser Leu Ala Gly Asn Lys Val Thr Asp Gln Gly Val Thr
            900                 905                 910         
Pro Leu Ser Asp Ala Leu Arg Val Ser Gln Cys Ala Leu Gln Lys Leu
        915                 920                 925             
Ile Leu Glu Asp Cys Gly Ile Thr Ala Thr Gly Cys Gln Ser Leu Ala
    930                 935                 940                 
Ser Ala Leu Val Ser Asn Arg Ser Leu Thr His Leu Cys Leu Ser Asn
945                 950                 955                 960 
Asn Ser Leu Gly Asn Glu Gly Val Asn Leu Leu Cys Arg Ser Met Arg
                965                 970                 975     
Leu Pro His Cys Ser Leu Gln Arg Leu Met Leu Asn Gln Cys His Leu
            980                 985                 990         
Asp Thr Ala Gly Cys Gly Ser Leu Ala Leu Ala Leu Met Gly Asn Ser
        995                 1000                1005            
Trp Leu Thr His Leu Ser Leu Ser Met Asn Pro Val Glu Asp Asn Gly
    1010                1015                1020                
Val Lys Leu Leu Cys Glu Val Met Arg Glu Pro Ser Cys His Leu Gln
1025                1030                1035                1040
Asp Leu Glu Leu Val Lys Cys His Leu Thr Ala Ala Cys Cys Glu Ser
                1045                1050                1055    
Leu Ser Cys Val Ile Ser Arg Ser Arg His Leu Lys Ser Leu Asp Leu
            1060                1065                1070        
Thr Asp Asn Ala Leu Gly Asp Gly Gly Val Ala Ala Leu Cys Glu Gly
        1075                1080                1085            
Leu Lys Gln Lys Asn Ser Val Leu Thr Arg Leu Gly Leu Lys Ala Cys
    1090                1095                1100                
Gly Leu Thr Ser Asp Cys Cys Glu Ala Leu Ser Leu Ala Leu Ser Cys
1105                1110                1115                1120
Asn Arg His Leu Thr Ser Leu Asn Leu Val Gln Asn Asn Phe Ser Pro
                1125                1130                1135    
Lys Gly Met Met Lys Leu Cys Ser Ala Phe Ala Cys Pro Thr Ser Asn
            1140                1145                1150        
Leu Gln Ile Ile Gly Leu Trp Lys Trp Gln Tyr Pro Val Gln Ile Arg
        1155                1160                1165            
Lys Leu Leu Glu Glu Val Gln Leu Leu Lys Pro Arg Val Val Ile Asp
    1170                1175                1180                
Gly Ser Trp His Ser Phe Asp Glu Asp Asp Arg Tyr Trp Trp Lys Asn
1185                1190                1195                1200


<210> 8716
<211> 729
<212> PRT
<213> Homo sapiens

<400> 8716
Met Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser
 1               5                  10                  15      
Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala
            20                  25                  30          
Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala
        35                  40                  45              
Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser
    50                  55                  60                  
Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met
65                  70                  75                  80  
Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly
                85                  90                  95      
Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn
            100                 105                 110         
Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro
        115                 120                 125             
Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu
    130                 135                 140                 
Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val
145                 150                 155                 160 
Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala
                165                 170                 175     
Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr
            180                 185                 190         
Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly
        195                 200                 205             
Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala
    210                 215                 220                 
Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu
225                 230                 235                 240 
Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu
                245                 250                 255     
Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg
            260                 265                 270         
Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile
        275                 280                 285             
Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg
    290                 295                 300                 
Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr
305                 310                 315                 320 
Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu
                325                 330                 335     
Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr
            340                 345                 350         
Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu
        355                 360                 365             
Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu
    370                 375                 380                 
Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser
385                 390                 395                 400 
Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu
                405                 410                 415     
Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp
            420                 425                 430         
Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile
        435                 440                 445             
His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe
    450                 455                 460                 
Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg
465                 470                 475                 480 
Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro
                485                 490                 495     
Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser
            500                 505                 510         
Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys
        515                 520                 525             
Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile
    530                 535                 540                 
Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly
545                 550                 555                 560 
Gly Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn Asn Pro
                565                 570                 575     
Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly Val Lys
            580                 585                 590         
Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser Glu Thr
        595                 600                 605             
Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro Asn Ser
    610                 615                 620                 
Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly Thr Tyr
625                 630                 635                 640 
Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu Tyr Gly
                645                 650                 655     
Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg Ser Ser
            660                 665                 670         
Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly Gln Gln
        675                 680                 685             
Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly Ala Thr
    690                 695                 700                 
Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro Pro Pro
705                 710                 715                 720 
Pro Pro Pro Pro Pro Pro Ser Arg Lys
                725                 


<210> 8717
<211> 543
<212> PRT
<213> Homo sapiens

<400> 8717
Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu
 1               5                  10                  15      
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr
            20                  25                  30          
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg
        35                  40                  45              
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala
    50                  55                  60                  
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg
65                  70                  75                  80  
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val
                85                  90                  95      
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser
            100                 105                 110         
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly
        115                 120                 125             
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln
    130                 135                 140                 
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro
145                 150                 155                 160 
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu
                165                 170                 175     
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp
            180                 185                 190         
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val
        195                 200                 205             
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu
    210                 215                 220                 
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu
225                 230                 235                 240 
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr
                245                 250                 255     
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile
            260                 265                 270         
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala
        275                 280                 285             
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala
    290                 295                 300                 
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val
305                 310                 315                 320 
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser
                325                 330                 335     
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val
            340                 345                 350         
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg
        355                 360                 365             
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe
    370                 375                 380                 
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro
385                 390                 395                 400 
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys
                405                 410                 415     
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val
            420                 425                 430         
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys
        435                 440                 445             
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser
    450                 455                 460                 
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu
465                 470                 475                 480 
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn
                485                 490                 495     
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys
            500                 505                 510         
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu
        515                 520                 525             
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln
    530                 535                 540             


<210> 8718
<211> 4590
<212> PRT
<213> Homo sapiens

<400> 8718
Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln
 1               5                  10                  15      
His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu
            20                  25                  30          
Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala
        35                  40                  45              
Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr
    50                  55                  60                  
His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu
65                  70                  75                  80  
Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu
                85                  90                  95      
Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val
            100                 105                 110         
Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn
        115                 120                 125             
Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp
    130                 135                 140                 
Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu
145                 150                 155                 160 
Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala
                165                 170                 175     
Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr
            180                 185                 190         
Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly
        195                 200                 205             
Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala
    210                 215                 220                 
Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met
225                 230                 235                 240 
Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val
                245                 250                 255     
Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala
            260                 265                 270         
Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp
        275                 280                 285             
Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg
    290                 295                 300                 
Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile
305                 310                 315                 320 
Gly Asp Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu
                325                 330                 335     
Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val
            340                 345                 350         
Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu
        355                 360                 365             
Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr
    370                 375                 380                 
Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr
385                 390                 395                 400 
Val Phe Lys Arg Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn
                405                 410                 415     
Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala
            420                 425                 430         
His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys
        435                 440                 445             
Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr
    450                 455                 460                 
Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr
465                 470                 475                 480 
Thr Ile Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly
                485                 490                 495     
Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile
            500                 505                 510         
Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu
        515                 520                 525             
Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly
    530                 535                 540                 
Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn
545                 550                 555                 560 
Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly
                565                 570                 575     
Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser
            580                 585                 590         
Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala
        595                 600                 605             
Gly Asn Glu Leu Asp Leu Phe Ser Leu Asn Pro Asn Ser Gly Val Leu
    610                 615                 620                 
Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe
625                 630                 635                 640 
His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro
                645                 650                 655     
Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu
            660                 665                 670         
Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu
        675                 680                 685             
Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe
    690                 695                 700                 
Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu
705                 710                 715                 720 
Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val
                725                 730                 735     
Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu
            740                 745                 750         
Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp
        755                 760                 765             
Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr
    770                 775                 780                 
Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro
785                 790                 795                 800 
Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn
                805                 810                 815     
Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser
            820                 825                 830         
Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp
        835                 840                 845             
Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Leu Thr Asp
    850                 855                 860                 
Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala
865                 870                 875                 880 
Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu
                885                 890                 895     
Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val
            900                 905                 910         
Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile
        915                 920                 925             
Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr
    930                 935                 940                 
Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly
945                 950                 955                 960 
Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val
                965                 970                 975     
Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu
            980                 985                 990         
Lys Lys Gln Val Tyr Asn Leu Thr Val Arg Ala Lys Asp Lys Gly Lys
        995                 1000                1005            
Pro Val Ser Leu Ser Ser Thr Cys Tyr Val Glu Val Glu Val Val Asp
    1010                1015                1020                
Val Asn Glu Asn Leu His Pro Pro Val Phe Ser Ser Phe Val Glu Lys
1025                1030                1035                1040
Gly Thr Val Lys Glu Asp Ala Pro Val Gly Ser Leu Val Met Thr Val
                1045                1050                1055    
Ser Ala His Asp Glu Asp Ala Gly Arg Asp Gly Glu Ile Arg Tyr Ser
            1060                1065                1070        
Ile Arg Asp Gly Ser Gly Val Gly Val Phe Lys Ile Gly Glu Glu Thr
        1075                1080                1085            
Gly Val Ile Glu Thr Ser Asp Arg Leu Asp Arg Glu Ser Thr Ser His
    1090                1095                1100                
Tyr Trp Leu Thr Val Phe Ala Thr Asp Gln Gly Val Val Pro Leu Ser
1105                1110                1115                1120
Ser Phe Ile Glu Ile Tyr Ile Glu Val Glu Asp Val Asn Asp Asn Ala
                1125                1130                1135    
Pro Gln Thr Ser Glu Pro Val Tyr Tyr Pro Glu Ile Met Glu Asn Ser
            1140                1145                1150        
Pro Lys Asp Val Ser Val Val Gln Ile Glu Ala Phe Asp Pro Asp Ser
        1155                1160                1165            
Ser Ser Asn Asp Lys Leu Met Tyr Lys Ile Thr Ser Gly Asn Pro Gln
    1170                1175                1180                
Gly Phe Phe Ser Ile His Pro Lys Thr Gly Leu Ile Thr Thr Thr Ser
1185                1190                1195                1200
Arg Lys Leu Asp Arg Glu Gln Gln Asp Glu His Ile Leu Glu Val Thr
                1205                1210                1215    
Val Thr Asp Asn Gly Ser Pro Pro Lys Ser Thr Ile Ala Arg Val Ile
            1220                1225                1230        
Val Lys Ile Leu Asp Glu Asn Asp Asn Lys Pro Gln Phe Leu Gln Lys
        1235                1240                1245            
Phe Tyr Lys Ile Arg Leu Pro Glu Arg Glu Lys Pro Asp Arg Glu Arg
    1250                1255                1260                
Asn Ala Arg Arg Glu Pro Leu Tyr Arg Val Ile Ala Thr Asp Lys Asp
1265                1270                1275                1280
Glu Gly Pro Asn Ala Glu Ile Ser Tyr Ser Ile Glu Asp Gly Asn Glu
                1285                1290                1295    
His Gly Lys Phe Phe Ile Glu Pro Lys Thr Gly Val Val Ser Ser Lys
            1300                1305                1310        
Arg Phe Ser Ala Ala Gly Glu Tyr Asp Ile Leu Ser Ile Lys Ala Val
        1315                1320                1325            
Asp Asn Gly Arg Pro Gln Lys Ser Ser Thr Thr Arg Leu His Ile Glu
    1330                1335                1340                
Trp Ile Ser Lys Pro Lys Gln Ser Leu Glu Pro Ile Ser Phe Glu Glu
1345                1350                1355                1360
Ser Phe Phe Thr Phe Thr Val Met Glu Ser Asp Pro Val Ala His Met
                1365                1370                1375    
Ile Gly Val Ile Ser Val Glu Pro Pro Gly Ile Pro Leu Trp Phe Asp
            1380                1385                1390        
Ile Thr Gly Gly Asn Tyr Asp Ser His Phe Asp Val Asp Lys Gly Thr
        1395                1400                1405            
Gly Thr Ile Ile Val Ala Lys Pro Leu Asp Ala Glu Gln Lys Ser Asn
    1410                1415                1420                
Tyr Asn Leu Thr Val Glu Ala Thr Asp Gly Thr Thr Thr Ile Leu Thr
1425                1430                1435                1440
Gln Val Phe Ile Lys Val Ile Asp Thr Asn Asp His Arg Pro Gln Phe
                1445                1450                1455    
Ser Thr Ser Lys Tyr Glu Val Val Ile Pro Glu Asp Thr Ala Pro Glu
            1460                1465                1470        
Thr Glu Ile Leu Gln Ile Ser Ala Val Asp Gln Asp Glu Lys Asn Lys
        1475                1480                1485            
Leu Ile Tyr Thr Leu Gln Ser Ser Arg Asp Pro Leu Ser Leu Lys Lys
    1490                1495                1500                
Phe Arg Leu Asp Pro Ala Thr Gly Ser Leu Tyr Thr Ser Glu Lys Leu
1505                1510                1515                1520
Asp His Glu Ala Val Ser Pro Ala His Leu Thr Val Met Val Arg Asp
                1525                1530                1535    
Gln Asp Val Pro Val Lys Arg Asn Phe Ala Arg Ile Val Val Asn Val
            1540                1545                1550        
Ser Asp Thr Asn Asp His Ala Pro Trp Phe Thr Ala Ser Ser Tyr Lys
        1555                1560                1565            
Gly Arg Val Tyr Glu Ser Ala Ala Val Gly Ser Val Val Leu Gln Val
    1570                1575                1580                
Thr Ala Leu Asp Lys Asp Lys Gly Lys Asn Ala Glu Val Leu Tyr Ser
1585                1590                1595                1600
Ile Glu Ser Gly Asn Ile Gly Asn Ile Gly Asn Ser Phe Met Ile Asp
                1605                1610                1615    
Pro Val Leu Gly Ser Ile Lys Thr Ala Lys Glu Leu Asp Arg Ser Asn
            1620                1625                1630        
Gln Ala Glu Tyr Asp Leu Met Val Lys Ala Thr Asp Lys Gly Ser Pro
        1635                1640                1645            
Pro Met Ser Glu Ile Thr Ser Val Arg Ile Phe Val Thr Ile Ala Asp
    1650                1655                1660                
Asn Ala Ser Pro Lys Phe Thr Ser Lys Glu Tyr Ser Val Glu Leu Ser
1665                1670                1675                1680
Glu Thr Val Ser Ile Gly Ser Phe Val Gly Met Val Thr Ala His Ser
                1685                1690                1695    
Gln Ser Ser Val Val Tyr Glu Ile Lys Asp Gly Asn Thr Gly Asp Ala
            1700                1705                1710        
Phe Asp Ile Asn Pro His Ser Gly Thr Ile Ile Thr Gln Lys Ala Leu
        1715                1720                1725            
Asp Phe Glu Thr Leu Pro Ile Tyr Thr Leu Ile Ile Gln Gly Thr Asn
    1730                1735                1740                
Met Ala Gly Leu Ser Thr Asn Thr Thr Val Leu Val His Leu Gln Asp
1745                1750                1755                1760
Glu Asn Asp Asn Ala Pro Val Phe Met Gln Ala Glu Tyr Thr Gly Leu
                1765                1770                1775    
Ile Ser Glu Ser Ala Ser Ile Asn Ser Val Val Leu Thr Asp Arg Asn
            1780                1785                1790        
Val Pro Leu Val Ile Arg Ala Ala Asp Ala Asp Lys Asp Ser Asn Ala
        1795                1800                1805            
Leu Leu Val Tyr His Ile Val Glu Pro Ser Val His Thr Tyr Phe Ala
    1810                1815                1820                
Ile Asp Ser Ser Thr Gly Ala Ile His Thr Val Leu Ser Leu Asp Tyr
1825                1830                1835                1840
Glu Glu Thr Ser Ile Phe His Phe Thr Val Gln Val His Asp Met Gly
                1845                1850                1855    
Thr Pro Arg Leu Phe Ala Glu Tyr Ala Ala Asn Val Thr Val His Val
            1860                1865                1870        
Ile Asp Ile Asn Asp Cys Pro Pro Val Phe Ala Lys Pro Leu Tyr Glu
        1875                1880                1885            
Ala Ser Leu Leu Leu Pro Thr Tyr Lys Gly Val Lys Val Ile Thr Val
    1890                1895                1900                
Asn Ala Thr Asp Ala Asp Ser Ser Ala Phe Ser Gln Leu Ile Tyr Ser
1905                1910                1915                1920
Ile Thr Glu Gly Asn Ile Gly Glu Lys Phe Ser Met Asp Tyr Lys Thr
                1925                1930                1935    
Gly Ala Leu Thr Val Gln Asn Thr Thr Gln Leu Arg Ser Arg Tyr Glu
            1940                1945                1950        
Leu Thr Val Arg Ala Ser Asp Gly Arg Phe Ala Gly Leu Thr Ser Val
        1955                1960                1965            
Lys Ile Asn Val Lys Glu Ser Lys Glu Ser His Leu Lys Phe Thr Gln
    1970                1975                1980                
Asp Val Tyr Ser Ala Val Val Lys Glu Asn Ser Thr Glu Ala Glu Thr
1985                1990                1995                2000
Leu Ala Val Ile Thr Ala Ile Gly Ser Pro Ile Asn Glu Pro Leu Phe
                2005                2010                2015    
Tyr His Ile Leu Asn Pro Asp Arg Arg Phe Lys Ile Ser Arg Thr Ser
            2020                2025                2030        
Gly Val Leu Ser Thr Thr Gly Thr Pro Phe Asp Arg Glu Gln Gln Glu
        2035                2040                2045            
Ala Phe Asp Val Val Val Glu Val Ile Glu Glu His Lys Pro Ser Ala
    2050                2055                2060                
Val Ala His Val Val Val Lys Val Ile Val Glu Asp Gln Asn Asp Asn
2065                2070                2075                2080
Ala Pro Val Phe Val Asn Leu Pro Tyr Tyr Ala Val Val Lys Val Asp
                2085                2090                2095    
Thr Glu Val Gly His Val Ile Arg Tyr Val Thr Ala Val Asp Arg Asp
            2100                2105                2110        
Ser Gly Arg Asn Gly Glu Val His Tyr Tyr Leu Lys Glu His His Glu
        2115                2120                2125            
His Phe Gln Ile Gly Pro Leu Gly Glu Ile Ser Leu Lys Lys Gln Phe
    2130                2135                2140                
Glu Leu Asp Thr Leu Asn Lys Glu Tyr Leu Val Thr Val Val Ala Lys
2145                2150                2155                2160
Asp Gly Gly Asn Pro Ala Phe Ser Ala Glu Val Ile Val Pro Ile Thr
                2165                2170                2175    
Val Met Asn Lys Ala Met Pro Val Phe Glu Lys Pro Phe Tyr Ser Ala
            2180                2185                2190        
Glu Ile Ala Glu Ser Ile Gln Val His Ser Pro Val Val His Val Gln
        2195                2200                2205            
Ala Asn Ser Pro Glu Gly Leu Lys Val Phe Tyr Ser Ile Thr Asp Gly
    2210                2215                2220                
Asp Pro Phe Ser Gln Phe Thr Ile Asn Phe Asn Thr Gly Val Ile Asn
2225                2230                2235                2240
Val Ile Ala Pro Leu Asp Phe Glu Ala His Pro Ala Tyr Lys Leu Ser
                2245                2250                2255    
Ile Arg Ala Thr Asp Ser Leu Thr Gly Ala His Ala Glu Val Phe Val
            2260                2265                2270        
Asp Ile Ile Val Asp Asp Ile Asn Asp Asn Pro Pro Val Phe Ala Gln
        2275                2280                2285            
Gln Ser Tyr Ala Val Thr Leu Ser Glu Ala Ser Val Ile Gly Thr Ser
    2290                2295                2300                
Val Val Gln Val Arg Ala Thr Asp Ser Asp Ser Glu Pro Asn Arg Gly
2305                2310                2315                2320
Ile Ser Tyr Gln Met Phe Gly Asn His Ser Lys Ser His Asp His Phe
                2325                2330                2335    
His Val Asp Ser Ser Thr Gly Leu Ile Ser Leu Leu Arg Thr Leu Asp
            2340                2345                2350        
Tyr Glu Gln Ser Arg Gln His Thr Ile Phe Val Arg Ala Val Asp Gly
        2355                2360                2365            
Gly Met Pro Thr Leu Ser Ser Asp Val Ile Val Thr Val Asp Val Thr
    2370                2375                2380                
Asp Leu Asn Gly Asn Pro Pro Leu Phe Glu Gln Gln Ile Tyr Glu Ala
2385                2390                2395                2400
Arg Ile Ser Glu His Ala Pro His Gly His Phe Val Thr Cys Val Lys
                2405                2410                2415    
Ala Tyr Asp Ala Asp Ser Ser Asp Ile Asp Lys Leu Gln Tyr Ser Ile
            2420                2425                2430        
Leu Ser Gly Asn Asp His Lys His Phe Val Ile Asp Ser Ala Thr Gly
        2435                2440                2445            
Ile Ile Thr Leu Ser Asn Leu His Arg His Ala Leu Lys Pro Phe Tyr
    2450                2455                2460                
Ser Leu Asn Leu Ser Val Ser Asp Gly Val Phe Arg Ser Ser Thr Gln
2465                2470                2475                2480
Val His Val Thr Val Ile Gly Gly Asn Leu His Ser Pro Ala Phe Leu
                2485                2490                2495    
Gln Asn Glu Tyr Glu Val Glu Leu Ala Glu Asn Ala Pro Leu His Thr
            2500                2505                2510        
Leu Val Met Glu Val Lys Thr Thr Asp Gly Asp Ser Gly Ile Tyr Gly
        2515                2520                2525            
His Val Thr Tyr His Ile Val Asn Asp Phe Ala Lys Asp Arg Phe Tyr
    2530                2535                2540                
Ile Asn Glu Arg Gly Gln Ile Phe Thr Leu Glu Lys Leu Asp Arg Glu
2545                2550                2555                2560
Thr Pro Ala Glu Lys Val Ile Ser Val Arg Leu Met Ala Lys Asp Ala
                2565                2570                2575    
Gly Gly Lys Val Ala Phe Cys Thr Val Asn Val Ile Leu Thr Asp Asp
            2580                2585                2590        
Asn Asp Asn Ala Pro Gln Phe Arg Ala Thr Lys Tyr Glu Val Asn Ile
        2595                2600                2605            
Gly Ser Ser Ala Ala Lys Gly Thr Ser Val Val Lys Ser Ala Ser Asp
    2610                2615                2620                
Ala Asp Glu Gly Ser Asn Ala Asp Ile Thr Tyr Ala Ile Glu Ala Asp
2625                2630                2635                2640
Ser Glu Ser Val Lys Glu Asn Leu Glu Ile Asn Lys Leu Ser Gly Val
                2645                2650                2655    
Ile Thr Thr Lys Glu Ser Leu Ile Gly Leu Glu Asn Glu Phe Phe Thr
            2660                2665                2670        
Phe Phe Val Arg Ala Val Asp Asn Gly Ser Pro Ser Lys Glu Ser Val
        2675                2680                2685            
Val Leu Val Tyr Val Lys Ile Leu Pro Pro Glu Met Gln Leu Pro Lys
    2690                2695                2700                
Phe Ser Glu Pro Phe Tyr Thr Phe Thr Val Ser Glu Asp Val Pro Val
2705                2710                2715                2720
Gly Thr Glu Ile Asp Leu Ile Arg Ala Glu His Ser Gly Thr Val Leu
                2725                2730                2735    
Tyr Ser Leu Val Lys Gly Asn Thr Pro Glu Ser Asn Arg Asp Glu Ser
            2740                2745                2750        
Phe Val Ile Asp Arg Gln Ser Gly Arg Leu Lys Leu Glu Lys Ser Leu
        2755                2760                2765            
Asp His Glu Thr Thr Lys Trp Tyr Gln Phe Ser Ile Leu Ala Arg Cys
    2770                2775                2780                
Thr Gln Asp Asp His Glu Met Val Ala Ser Val Asp Val Ser Ile Gln
2785                2790                2795                2800
Val Lys Asp Ala Asn Asp Asn Ser Pro Val Phe Glu Ser Ser Pro Tyr
                2805                2810                2815    
Glu Ala Phe Ile Val Glu Asn Leu Pro Gly Gly Ser Arg Val Ile Gln
            2820                2825                2830        
Ile Arg Ala Ser Asp Ala Asp Ser Gly Thr Asn Gly Gln Val Met Tyr
        2835                2840                2845            
Ser Leu Asp Gln Ser Gln Ser Val Glu Val Ile Glu Ser Phe Ala Ile
    2850                2855                2860                
Asn Met Glu Thr Gly Trp Ile Thr Thr Leu Lys Glu Leu Asp His Glu
2865                2870                2875                2880
Lys Arg Asp Asn Tyr Gln Ile Lys Val Val Ala Ser Asp His Gly Glu
                2885                2890                2895    
Lys Ile Gln Leu Ser Ser Thr Ala Ile Val Asp Val Thr Val Thr Asp
            2900                2905                2910        
Val Asn Asp Ser Pro Pro Arg Phe Thr Ala Glu Ile Tyr Lys Gly Thr
        2915                2920                2925            
Val Ser Glu Asp Asp Pro Gln Gly Gly Val Ile Ala Ile Leu Ser Thr
    2930                2935                2940                
Thr Asp Ala Asp Ser Glu Glu Ile Asn Arg Gln Val Thr Tyr Phe Ile
2945                2950                2955                2960
Thr Gly Gly Asp Pro Leu Gly Gln Phe Ala Val Glu Thr Ile Gln Asn
                2965                2970                2975    
Glu Trp Lys Val Tyr Val Lys Lys Pro Leu Asp Arg Glu Lys Arg Asp
            2980                2985                2990        
Asn Tyr Leu Leu Thr Ile Thr Ala Thr Asp Gly Thr Phe Ser Ser Lys
        2995                3000                3005            
Ala Ile Val Glu Val Lys Val Leu Asp Ala Asn Asp Asn Ser Pro Val
    3010                3015                3020                
Cys Glu Lys Thr Leu Tyr Ser Asp Thr Ile Pro Glu Asp Val Leu Pro
3025                3030                3035                3040
Gly Lys Leu Ile Met Gln Ile Ser Ala Thr Asp Ala Asp Ile Arg Ser
                3045                3050                3055    
Asn Ala Glu Ile Thr Tyr Thr Leu Leu Gly Ser Gly Ala Glu Lys Phe
            3060                3065                3070        
Lys Leu Asn Pro Asp Thr Gly Glu Leu Lys Thr Ser Thr Pro Leu Asp
        3075                3080                3085            
Arg Glu Glu Gln Ala Val Tyr His Leu Leu Val Arg Ala Thr Asp Gly
    3090                3095                3100                
Gly Gly Arg Phe Cys Gln Ala Ser Ile Val Val Thr Leu Glu Asp Val
3105                3110                3115                3120
Asn Asp Asn Ala Pro Glu Phe Ser Ala Asp Pro Tyr Ala Ile Thr Val
                3125                3130                3135    
Phe Glu Asn Thr Glu Pro Gly Thr Leu Leu Thr Arg Val Gln Ala Thr
            3140                3145                3150        
Asp Ala Asp Ala Gly Leu Asn Arg Lys Ile Leu Tyr Ser Leu Ile Asp
        3155                3160                3165            
Ser Ala Asp Gly Gln Phe Ser Ile Asn Glu Leu Ser Gly Ile Ile Gln
    3170                3175                3180                
Leu Glu Lys Pro Leu Asp Arg Glu Leu Gln Ala Val Tyr Thr Leu Ser
3185                3190                3195                3200
Leu Lys Ala Val Asp Gln Gly Leu Pro Arg Arg Leu Thr Ala Thr Gly
                3205                3210                3215    
Thr Val Ile Val Ser Val Leu Asp Ile Asn Asp Asn Pro Pro Val Phe
            3220                3225                3230        
Glu Tyr Arg Glu Tyr Gly Ala Thr Val Ser Glu Asp Ile Leu Val Gly
        3235                3240                3245            
Thr Glu Val Leu Gln Val Tyr Ala Ala Ser Arg Asp Ile Glu Ala Asn
    3250                3255                3260                
Ala Glu Ile Thr Tyr Ser Ile Ile Ser Gly Asn Glu His Gly Lys Phe
3265                3270                3275                3280
Ser Ile Asp Ser Lys Thr Gly Ala Val Phe Ile Ile Glu Asn Leu Asp
                3285                3290                3295    
Tyr Glu Ser Ser His Glu Tyr Tyr Leu Thr Val Glu Ala Thr Asp Gly
            3300                3305                3310        
Gly Thr Pro Ser Leu Ser Asp Val Ala Thr Val Asn Val Asn Val Thr
        3315                3320                3325            
Asp Ile Asn Asp Asn Thr Pro Val Phe Ser Gln Asp Thr Tyr Thr Thr
    3330                3335                3340                
Val Ile Ser Glu Asp Ala Val Leu Glu Gln Ser Val Ile Thr Val Met
3345                3350                3355                3360
Ala Asp Asp Ala Asp Gly Pro Ser Asn Ser His Ile His Tyr Ser Ile
                3365                3370                3375    
Ile Asp Gly Asn Gln Gly Ser Ser Phe Thr Ile Asp Pro Val Arg Gly
            3380                3385                3390        
Glu Val Lys Val Thr Lys Leu Leu Asp Arg Glu Thr Ile Ser Gly Tyr
        3395                3400                3405            
Thr Leu Thr Val Gln Ala Ser Asp Asn Gly Ser Pro Pro Arg Val Asn
    3410                3415                3420                
Thr Thr Thr Val Asn Ile Asp Val Ser Asp Val Asn Asp Asn Ala Pro
3425                3430                3435                3440
Val Phe Ser Arg Gly Asn Tyr Ser Val Ile Ile Gln Glu Asn Lys Pro
                3445                3450                3455    
Val Gly Phe Ser Val Leu Gln Leu Val Val Thr Asp Glu Asp Ser Ser
            3460                3465                3470        
His Asn Gly Pro Pro Phe Phe Phe Thr Ile Val Thr Gly Asn Asp Glu
        3475                3480                3485            
Lys Ala Phe Glu Val Asn Pro Gln Gly Val Leu Leu Thr Ser Ser Ala
    3490                3495                3500                
Ile Lys Arg Lys Glu Lys Asp His Tyr Leu Leu Gln Val Lys Val Ala
3505                3510                3515                3520
Asp Asn Gly Lys Pro Gln Leu Ser Ser Leu Thr Tyr Ile Asp Ile Arg
                3525                3530                3535    
Val Ile Glu Glu Ser Ile Tyr Pro Pro Ala Ile Leu Pro Leu Glu Ile
            3540                3545                3550        
Phe Ile Thr Ser Ser Gly Glu Glu Tyr Ser Gly Gly Val Ile Gly Lys
        3555                3560                3565            
Ile His Ala Thr Asp Gln Asp Val Tyr Asp Thr Leu Thr Tyr Ser Leu
    3570                3575                3580                
Asp Pro Gln Met Asp Asn Leu Phe Ser Val Ser Ser Thr Gly Gly Lys
3585                3590                3595                3600
Leu Ile Ala His Lys Lys Leu Asp Ile Gly Gln Tyr Leu Leu Asn Val
                3605                3610                3615    
Ser Val Thr Asp Gly Lys Phe Thr Thr Val Ala Asp Ile Thr Val His
            3620                3625                3630        
Ile Arg Gln Val Thr Gln Glu Met Leu Asn His Thr Ile Ala Ile Arg
        3635                3640                3645            
Phe Ala Asn Leu Thr Pro Glu Glu Phe Val Gly Asp Tyr Trp Arg Asn
    3650                3655                3660                
Phe Gln Arg Ala Leu Arg Asn Ile Leu Gly Val Arg Arg Asn Asp Ile
3665                3670                3675                3680
Gln Ile Val Ser Leu Gln Ser Ser Glu Pro His Pro His Leu Asp Val
                3685                3690                3695    
Leu Leu Phe Val Glu Lys Pro Gly Ser Ala Gln Ile Ser Thr Lys Gln
            3700                3705                3710        
Leu Leu His Lys Ile Asn Ser Ser Val Thr Asp Ile Glu Glu Ile Ile
        3715                3720                3725            
Gly Val Arg Ile Leu Asn Val Phe Gln Lys Leu Cys Ala Gly Leu Asp
    3730                3735                3740                
Cys Pro Trp Lys Phe Cys Asp Glu Lys Val Ser Val Asp Glu Ser Val
3745                3750                3755                3760
Met Ser Thr His Ser Thr Ala Arg Leu Ser Phe Val Thr Pro Arg His
                3765                3770                3775    
His Arg Ala Ala Val Cys Leu Cys Lys Glu Gly Arg Cys Pro Pro Val
            3780                3785                3790        
His His Gly Cys Glu Asp Asp Pro Cys Pro Glu Gly Ser Glu Cys Val
        3795                3800                3805            
Ser Asp Pro Trp Glu Glu Lys His Thr Cys Val Cys Pro Ser Gly Arg
    3810                3815                3820                
Phe Gly Gln Cys Pro Gly Ser Ser Ser Met Thr Leu Thr Gly Asn Ser
3825                3830                3835                3840
Tyr Val Lys Tyr Arg Leu Thr Glu Asn Glu Asn Lys Leu Glu Met Lys
                3845                3850                3855    
Leu Thr Met Arg Leu Arg Thr Tyr Ser Thr His Ala Val Val Met Tyr
            3860                3865                3870        
Ala Arg Gly Thr Asp Tyr Ser Ile Leu Glu Ile His His Gly Arg Leu
        3875                3880                3885            
Gln Tyr Lys Phe Asp Cys Gly Ser Gly Pro Gly Ile Val Ser Val Gln
    3890                3895                3900                
Ser Ile Gln Val Asn Asp Gly Gln Trp His Ala Val Ala Leu Glu Val
3905                3910                3915                3920
Asn Gly Asn Tyr Ala Arg Leu Val Leu Asp Gln Val His Thr Ala Ser
                3925                3930                3935    
Gly Thr Ala Pro Gly Thr Leu Lys Thr Leu Asn Leu Asp Asn Tyr Val
            3940                3945                3950        
Phe Phe Gly Gly His Ile Arg Gln Gln Gly Thr Arg His Gly Arg Ser
        3955                3960                3965            
Pro Gln Val Gly Asn Gly Phe Arg Gly Cys Met Asp Ser Ile Tyr Leu
    3970                3975                3980                
Asn Gly Gln Glu Leu Pro Leu Asn Ser Lys Pro Arg Ser Tyr Ala His
3985                3990                3995                4000
Ile Glu Glu Ser Val Asp Val Ser Pro Gly Cys Phe Leu Thr Ala Thr
                4005                4010                4015    
Glu Asp Cys Ala Ser Asn Pro Cys Gln Asn Gly Gly Val Cys Asn Pro
            4020                4025                4030        
Ser Pro Ala Gly Gly Tyr Tyr Cys Lys Cys Ser Ala Leu Tyr Ile Gly
        4035                4040                4045            
Thr His Cys Glu Ile Ser Val Asn Pro Cys Ser Ser Asn Pro Cys Leu
    4050                4055                4060                
Tyr Gly Gly Thr Cys Val Val Asp Asn Gly Gly Phe Val Cys Gln Cys
4065                4070                4075                4080
Arg Gly Leu Tyr Thr Gly Gln Arg Cys Gln Leu Ser Pro Tyr Cys Lys
                4085                4090                4095    
Asp Glu Pro Cys Lys Asn Gly Gly Thr Cys Phe Asp Ser Leu Asp Gly
            4100                4105                4110        
Ala Val Cys Gln Cys Asp Ser Gly Phe Arg Gly Glu Arg Cys Gln Ser
        4115                4120                4125            
Asp Ile Asp Glu Cys Ser Gly Asn Pro Cys Leu His Gly Ala Leu Cys
    4130                4135                4140                
Glu Asn Thr His Gly Ser Tyr His Cys Asn Cys Ser His Glu Tyr Arg
4145                4150                4155                4160
Gly Arg His Cys Glu Asp Ala Ala Pro Asn Gln Tyr Val Ser Thr Pro
                4165                4170                4175    
Trp Asn Ile Gly Leu Ala Glu Gly Ile Gly Ile Val Val Phe Val Ala
            4180                4185                4190        
Gly Ile Phe Leu Leu Val Val Val Phe Val Leu Cys Arg Lys Met Ile
        4195                4200                4205            
Ser Arg Lys Lys Lys His Gln Ala Glu Pro Lys Asp Lys His Leu Gly
    4210                4215                4220                
Pro Ala Thr Ala Phe Leu Gln Arg Pro Tyr Phe Asp Ser Lys Leu Asn
4225                4230                4235                4240
Lys Asn Ile Tyr Ser Asp Ile Pro Pro Gln Val Pro Val Arg Pro Ile
                4245                4250                4255    
Ser Tyr Thr Pro Ser Ile Pro Ser Asp Ser Arg Asn Asn Leu Asp Arg
            4260                4265                4270        
Asn Ser Phe Glu Gly Ser Ala Ile Pro Glu His Pro Glu Phe Ser Thr
        4275                4280                4285            
Phe Asn Pro Glu Ser Val His Gly His Arg Lys Ala Val Ala Val Cys
    4290                4295                4300                
Ser Val Ala Pro Asn Leu Pro Pro Pro Pro Pro Ser Asn Ser Pro Ser
4305                4310                4315                4320
Asp Ser Asp Ser Ile Gln Lys Pro Ser Trp Asp Phe Asp Tyr Asp Thr
                4325                4330                4335    
Lys Val Val Asp Leu Asp Pro Cys Leu Ser Lys Lys Pro Leu Glu Glu
            4340                4345                4350        
Lys Pro Ser Gln Pro Tyr Ser Ala Arg Glu Ser Leu Ser Glu Val Gln
        4355                4360                4365            
Ser Leu Ser Ser Phe Gln Ser Glu Ser Cys Asp Asp Asn Gly Tyr His
    4370                4375                4380                
Trp Asp Thr Ser Asp Trp Met Pro Ser Val Pro Leu Pro Asp Ile Gln
4385                4390                4395                4400
Glu Phe Pro Asn Tyr Glu Val Ile Asp Glu Gln Thr Pro Leu Tyr Ser
                4405                4410                4415    
Ala Asp Pro Asn Ala Ile Asp Thr Asp Tyr Tyr Pro Gly Gly Tyr Asp
            4420                4425                4430        
Ile Glu Ser Asp Phe Pro Pro Pro Pro Glu Asp Phe Pro Ala Ala Asp
        4435                4440                4445            
Glu Leu Pro Pro Leu Pro Pro Glu Phe Ser Asn Gln Phe Glu Ser Ile
    4450                4455                4460                
His Pro Pro Arg Asp Met Pro Ala Ala Gly Ser Leu Gly Ser Ser Ser
4465                4470                4475                4480
Arg Asn Arg Gln Arg Phe Asn Leu Asn Gln Tyr Leu Pro Asn Phe Tyr
                4485                4490                4495    
Pro Leu Asp Met Ser Glu Pro Gln Thr Lys Gly Thr Gly Glu Asn Ser
            4500                4505                4510        
Thr Cys Arg Glu Pro His Ala Pro Tyr Pro Pro Gly Tyr Gln Arg His
        4515                4520                4525            
Phe Glu Ala Pro Ala Val Glu Ser Met Pro Met Ser Val Tyr Ala Ser
    4530                4535                4540                
Thr Ala Ser Cys Ser Asp Val Ser Ala Cys Cys Glu Val Glu Ser Glu
4545                4550                4555                4560
Val Met Met Ser Asp Tyr Glu Ser Gly Asp Asp Gly His Phe Glu Glu
                4565                4570                4575    
Val Thr Ile Pro Pro Leu Asp Ser Gln Gln His Thr Glu Val
            4580                4585                4590


<210> 8719
<211> 1116
<212> PRT
<213> Homo sapiens

<400> 8719
Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg
            20                  25                  30          
Ala Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly
        35                  40                  45              
Ala Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala
    50                  55                  60                  
Val Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala
65                  70                  75                  80  
Ala Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr
                85                  90                  95      
Glu Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp
            100                 105                 110         
Gly Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp
        115                 120                 125             
Asp Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys
    130                 135                 140                 
Pro Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala
145                 150                 155                 160 
Leu Phe Gln Trp Asp Gln Asp Arg Glu Ser Met Glu Thr Val Pro Phe
                165                 170                 175     
Thr Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val
            180                 185                 190         
Val Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr
        195                 200                 205             
Ser Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp
    210                 215                 220                 
Asp Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg
225                 230                 235                 240 
Thr Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys
                245                 250                 255     
Trp Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met
            260                 265                 270         
Glu Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn
        275                 280                 285             
Thr Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala
    290                 295                 300                 
Ile Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met
305                 310                 315                 320 
Ala Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys
                325                 330                 335     
Thr Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro
            340                 345                 350         
Ile Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu
        355                 360                 365             
Glu Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn
    370                 375                 380                 
Ser Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser
385                 390                 395                 400 
Val Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser
                405                 410                 415     
Val Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys
            420                 425                 430         
Pro Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp
        435                 440                 445             
Glu Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr
    450                 455                 460                 
Ser Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr
465                 470                 475                 480 
Tyr Leu Pro Tyr Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile
                485                 490                 495     
Thr Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys
            500                 505                 510         
Lys Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr
        515                 520                 525             
Ile Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe
    530                 535                 540                 
His Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln
545                 550                 555                 560 
Thr Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser
                565                 570                 575     
Trp Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp
            580                 585                 590         
Phe Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe
        595                 600                 605             
Glu Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile
    610                 615                 620                 
Arg Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val
625                 630                 635                 640 
Lys Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn
                645                 650                 655     
Ala Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu
            660                 665                 670         
Ile Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser
        675                 680                 685             
Pro Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ala
    690                 695                 700                 
Thr Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg
705                 710                 715                 720 
Ser Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser
                725                 730                 735     
Gln Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser
            740                 745                 750         
Glu Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp
        755                 760                 765             
Cys Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser
    770                 775                 780                 
Phe Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu
785                 790                 795                 800 
Arg Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala
                805                 810                 815     
Ser Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His
            820                 825                 830         
Cys Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser
        835                 840                 845             
Ser Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser
    850                 855                 860                 
Leu Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro
865                 870                 875                 880 
Lys Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu
                885                 890                 895     
Lys Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser
            900                 905                 910         
Val Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu
        915                 920                 925             
His Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe
    930                 935                 940                 
Phe Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr
945                 950                 955                 960 
Ala Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro
                965                 970                 975     
Ala Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser
            980                 985                 990         
Pro Glu Gln Ile His Gly Asn Ser Tyr Ser His Lys Val Asp Ile Phe
        995                 1000                1005            
Ser Leu Gly Leu Ile Leu Phe Glu Leu Leu Tyr Pro Phe Ser Thr Gln
    1010                1015                1020                
Met Glu Arg Val Arg Thr Leu Thr Asp Val Arg Asn Leu Lys Phe Pro
1025                1030                1035                1040
Pro Leu Phe Thr Gln Lys Tyr Pro Cys Glu Tyr Val Met Val Gln Asp
                1045                1050                1055    
Met Leu Ser Pro Ser Pro Met Glu Arg Pro Glu Ala Ile Asn Ile Ile
            1060                1065                1070        
Glu Asn Ala Val Phe Glu Asp Leu Asp Phe Pro Gly Lys Thr Val Leu
        1075                1080                1085            
Arg Gln Arg Ser Arg Ser Leu Ser Ser Ser Gly Thr Lys His Ser Arg
    1090                1095                1100                
Gln Ser Asn Asn Ser His Ser Pro Leu Pro Ser Asn
1105                1110                1115    


<210> 8720
<211> 828
<212> PRT
<213> Homo sapiens

<400> 8720
Met Ala Arg Leu Cys Arg Arg Val Pro Cys Thr Leu Leu Leu Gly Leu
 1               5                  10                  15      
Ala Val Val Leu Leu Lys Ala Arg Leu Val Pro Ala Ala Ala Arg Ala
            20                  25                  30          
Glu Leu Ser Arg Ser Asp Leu Ser Leu Ile Gln Gln Gln Gln Gln Gln
        35                  40                  45              
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Gln Leu Glu Glu Ala
    50                  55                  60                  
Glu Glu Glu Arg Thr Glu Val Pro Gly Ala Thr Ser Thr Leu Thr Val
65                  70                  75                  80  
Pro Val Ser Val Phe Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser
                85                  90                  95      
Arg Gln Tyr Leu Ser Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr
            100                 105                 110         
Lys Thr Asn Ser Thr Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys
        115                 120                 125             
Val Pro Tyr Lys Leu Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp
    130                 135                 140                 
Gly Tyr Val Leu Thr Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile
145                 150                 155                 160 
Tyr Ser Ser Val Thr Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile
                165                 170                 175     
Trp Leu Phe Glu Asp Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala
            180                 185                 190         
Lys Ser Gln Pro Ser Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro
        195                 200                 205             
Asp Asn His His Ile Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln
    210                 215                 220                 
Gln Phe Leu Lys Val Asp Asn Phe Leu His Thr Thr Gly Ile Thr Leu
225                 230                 235                 240 
Asn Lys Pro Gly Phe Glu Asn Ile Glu Leu Thr Pro Leu Ala Ala Ile
                245                 250                 255     
Cys Val Lys Ile Tyr Ser Gly Gly Lys Glu Leu Lys Val Asn Gly Ser
            260                 265                 270         
Ile Gln Val Ser Leu Pro Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly
        275                 280                 285             
Asp Arg Ile Pro Ala Trp Thr Phe Asp Met Asn Thr Gly Ala Trp Ile
    290                 295                 300                 
Asn His Gly Arg Gly Met Val Lys Glu His Asn Asn His Leu Ile Trp
305                 310                 315                 320 
Thr Tyr Asp Ala Pro His Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro
                325                 330                 335     
Gly Thr Arg Gly Ser Gly Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala
            340                 345                 350         
Tyr His Thr Val Phe Leu Thr Ala Ile Leu Gly Gly Thr Ile Val Ile
        355                 360                 365             
Val Ile Gly Phe Phe Ala Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys
    370                 375                 380                 
Gly Thr Pro Gln Lys Arg Glu Arg Asn Ile Thr Lys Leu Glu Val Leu
385                 390                 395                 400 
Lys Arg Asp Gln Thr Thr Ser Thr Thr His Ile Asn His Ile Ser Thr
                405                 410                 415     
Val Lys Val Ala Leu Lys Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala
            420                 425                 430         
Lys Asn Ser Ser Tyr Ser Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu
        435                 440                 445             
Thr Glu Glu Arg Val Ser Met Val Lys Thr Arg Asp Asp Phe Lys Ile
    450                 455                 460                 
Tyr Asn Glu Asp Val Ser Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser
465                 470                 475                 480 
Arg Asn Pro Thr Gln Ser Leu Glu Pro Asn Val Gly Ser Lys Gln Pro
                485                 490                 495     
Lys His Ile Asn Asn Asn Leu Ser Ser Ser Leu Gly Asp Ala Gln Asp
            500                 505                 510         
Glu Lys Arg Tyr Leu Thr Gly Asn Glu Glu Ala Tyr Gly Arg Ser His
        515                 520                 525             
Ile Pro Glu Gln Leu Met His Ile Tyr Ser Gln Pro Ile Ala Ile Leu
    530                 535                 540                 
Gln Thr Ser Asp Leu Phe Ser Thr Pro Glu Gln Leu His Thr Ala Lys
545                 550                 555                 560 
Ser Ala Thr Leu Pro Arg Lys Gly Gln Leu Val Tyr Gly Gln Leu Met
                565                 570                 575     
Glu Pro Val Asn Arg Glu Asn Phe Thr Gln Thr Leu Pro Lys Met Pro
            580                 585                 590         
Ile His Ser His Ala Gln Pro Pro Asp Ala Arg Glu Glu Asp Ile Ile
        595                 600                 605             
Leu Glu Gly Gln Gln Ser Leu Pro Ser Gln Ala Ser Asp Trp Ser Arg
    610                 615                 620                 
Tyr Ser Ser Ser Leu Leu Glu Ser Val Ser Val Pro Gly Thr Leu Asn
625                 630                 635                 640 
Glu Ala Val Val Met Thr Pro Phe Ser Ser Glu Leu Gln Gly Ile Ser
                645                 650                 655     
Glu Gln Thr Leu Leu Glu Leu Ser Lys Gly Lys Pro Ser Pro His Pro
            660                 665                 670         
Arg Ala Trp Phe Val Ser Leu Asp Gly Lys Pro Val Ala Gln Val Arg
        675                 680                 685             
His Ser Phe Ile Asp Leu Lys Lys Gly Lys Arg Thr Gln Ser Asn Asp
    690                 695                 700                 
Thr Ser Leu Asp Ser Gly Val Asp Met Asn Glu Leu His Ser Ser Arg
705                 710                 715                 720 
Lys Leu Glu Arg Glu Lys Thr Phe Ile Lys Ser Met His Gln Pro Lys
                725                 730                 735     
Ile Leu Tyr Leu Glu Asp Leu Asp Leu Ser Ser Ser Glu Ser Gly Thr
            740                 745                 750         
Thr Val Cys Ser Pro Glu Asp Pro Ala Leu Arg His Ile Leu Asp Gly
        755                 760                 765             
Gly Ser Gly Val Ile Met Glu His Pro Gly Glu Glu Ser Pro Gly Arg
    770                 775                 780                 
Lys Ser Thr Val Glu Asp Phe Glu Ala Asn Thr Ser Pro Thr Lys Arg
785                 790                 795                 800 
Arg Gly Arg Pro Pro Leu Ala Lys Arg Asp Ser Lys Thr Asn Ile Trp
                805                 810                 815     
Lys Lys Arg Glu Glu Arg Pro Leu Ile Pro Ile Asn
            820                 825             


<210> 8721
<211> 296
<212> PRT
<213> Homo sapiens

<400> 8721
Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu
 1               5                  10                  15      
Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe
            20                  25                  30          
Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp
        35                  40                  45              
Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys
    50                  55                  60                  
Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu
65                  70                  75                  80  
Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln
                85                  90                  95      
Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln
            100                 105                 110         
Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu
        115                 120                 125             
Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp
    130                 135                 140                 
Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys
145                 150                 155                 160 
Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val
                165                 170                 175     
Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn
            180                 185                 190         
Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn
        195                 200                 205             
Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro
    210                 215                 220                 
Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu
225                 230                 235                 240 
Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu
                245                 250                 255     
Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr
            260                 265                 270         
Ile Asn Ile Ser Leu Ser Leu His Arg Arg Ser Arg Lys Arg Ala Gln
        275                 280                 285             
Glu Asn Glu Val Thr Gln His Gly
    290                 295     


<210> 8722
<211> 402
<212> PRT
<213> Homo sapiens

<400> 8722
Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His
 1               5                  10                  15      
Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg
            20                  25                  30          
Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro
        35                  40                  45              
Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr
    50                  55                  60                  
Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser
65                  70                  75                  80  
Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp
                85                  90                  95      
Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met
            100                 105                 110         
Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu
        115                 120                 125             
Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys
    130                 135                 140                 
Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu
145                 150                 155                 160 
Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln
                165                 170                 175     
Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser
            180                 185                 190         
Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu
        195                 200                 205             
Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr
    210                 215                 220                 
Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala
225                 230                 235                 240 
Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp
                245                 250                 255     
Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu
            260                 265                 270         
Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp
        275                 280                 285             
Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile
    290                 295                 300                 
Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn
305                 310                 315                 320 
Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp
                325                 330                 335     
Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser
            340                 345                 350         
Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln
        355                 360                 365             
Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg
    370                 375                 380                 
Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn
385                 390                 395                 400 
Tyr Arg
        


<210> 8723
<211> 498
<212> PRT
<213> Homo sapiens

<400> 8723
Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His
 1               5                  10                  15      
Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg
            20                  25                  30          
Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro
        35                  40                  45              
Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr
    50                  55                  60                  
Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser
65                  70                  75                  80  
Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp
                85                  90                  95      
Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met
            100                 105                 110         
Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu
        115                 120                 125             
Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys
    130                 135                 140                 
Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu
145                 150                 155                 160 
Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln
                165                 170                 175     
Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser
            180                 185                 190         
Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu
        195                 200                 205             
Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr
    210                 215                 220                 
Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala
225                 230                 235                 240 
Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp
                245                 250                 255     
Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu
            260                 265                 270         
Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp
        275                 280                 285             
Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile
    290                 295                 300                 
Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn
305                 310                 315                 320 
Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp
                325                 330                 335     
Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser
            340                 345                 350         
Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln
        355                 360                 365             
Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg
    370                 375                 380                 
Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn
385                 390                 395                 400 
Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser
                405                 410                 415     
Ser Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn
            420                 425                 430         
Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp
        435                 440                 445             
Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala
    450                 455                 460                 
Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys
465                 470                 475                 480 
Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu
                485                 490                 495     
Asp Phe
        


<210> 8724
<211> 437
<212> PRT
<213> Homo sapiens

<400> 8724
Met Gly Arg Arg Met Arg Gly Ala Ala Ala Thr Ala Gly Leu Trp Leu
 1               5                  10                  15      
Leu Ala Leu Gly Ser Leu Leu Ala Leu Trp Gly Gly Leu Leu Pro Pro
            20                  25                  30          
Arg Thr Glu Leu Pro Ala Ser Arg Pro Pro Glu Asp Arg Leu Pro Arg
        35                  40                  45              
Arg Pro Ala Arg Ser Gly Gly Pro Ala Pro Ala Pro Arg Phe Pro Leu
    50                  55                  60                  
Pro Pro Pro Leu Ala Trp Asp Ala Arg Gly Gly Ser Leu Lys Thr Phe
65                  70                  75                  80  
Arg Ala Leu Leu Thr Leu Ala Ala Gly Ala Asp Gly Pro Pro Arg Gln
                85                  90                  95      
Ser Arg Ser Glu Pro Arg Trp His Val Ser Ala Arg Gln Pro Arg Pro
            100                 105                 110         
Glu Glu Ser Ala Ala Val His Gly Gly Val Phe Trp Ser Arg Gly Leu
        115                 120                 125             
Glu Glu Gln Val Pro Pro Gly Phe Ser Glu Ala Gln Ala Ala Ala Trp
    130                 135                 140                 
Leu Glu Ala Ala Arg Gly Ala Arg Met Val Ala Leu Glu Arg Gly Gly
145                 150                 155                 160 
Cys Gly Arg Ser Ser Asn Arg Leu Ala Arg Phe Ala Asp Gly Thr Arg
                165                 170                 175     
Ala Cys Val Arg Tyr Gly Ile Asn Pro Glu Gln Ile Gln Gly Glu Ala
            180                 185                 190         
Leu Ser Tyr Tyr Leu Ala Arg Leu Leu Gly Leu Gln Arg His Val Pro
        195                 200                 205             
Pro Leu Ala Leu Ala Arg Val Glu Ala Arg Gly Ala Gln Trp Ala Gln
    210                 215                 220                 
Val Gln Glu Glu Leu Arg Ala Ala His Trp Thr Glu Gly Ser Val Val
225                 230                 235                 240 
Ser Leu Thr Arg Trp Leu Pro Asn Leu Thr Asp Val Val Val Pro Ala
                245                 250                 255     
Pro Trp Arg Ser Glu Asp Gly Arg Leu Arg Pro Leu Arg Asp Ala Gly
            260                 265                 270         
Gly Glu Leu Ala Asn Leu Ser Gln Ala Glu Leu Val Asp Leu Val Gln
        275                 280                 285             
Trp Thr Asp Leu Ile Leu Phe Asp Tyr Leu Thr Ala Asn Phe Asp Arg
    290                 295                 300                 
Leu Val Ser Asn Leu Phe Ser Leu Gln Trp Asp Pro Arg Val Met Gln
305                 310                 315                 320 
Arg Ala Thr Ser Asn Leu His Arg Gly Pro Gly Gly Ala Leu Val Phe
                325                 330                 335     
Leu Asp Asn Glu Ala Gly Leu Val His Gly Tyr Arg Val Ala Gly Met
            340                 345                 350         
Trp Asp Lys Tyr Asn Glu Pro Leu Leu Gln Ser Val Cys Val Phe Arg
        355                 360                 365             
Glu Arg Thr Ala Arg Arg Val Leu Glu Leu His Arg Gly Gln Asp Ala
    370                 375                 380                 
Ala Ala Arg Leu Leu Arg Leu Tyr Arg Arg His Glu Pro Arg Phe Pro
385                 390                 395                 400 
Glu Leu Ala Ala Leu Ala Asp Pro His Ala Gln Leu Leu Gln Arg Arg
                405                 410                 415     
Leu Asp Phe Leu Ala Lys His Ile Leu His Cys Lys Ala Lys Tyr Gly
            420                 425                 430         
Arg Arg Ser Gly Thr
        435         


<210> 8725
<211> 453
<212> PRT
<213> Homo sapiens

<400> 8725
Met Gly Arg Arg Met Arg Gly Ala Ala Ala Thr Ala Gly Leu Trp Leu
 1               5                  10                  15      
Leu Ala Leu Gly Ser Leu Leu Ala Leu Trp Gly Gly Leu Leu Pro Pro
            20                  25                  30          
Arg Thr Glu Leu Pro Ala Ser Arg Pro Pro Glu Asp Arg Leu Pro Arg
        35                  40                  45              
Arg Pro Ala Arg Ser Gly Gly Pro Ala Arg Ala Pro Arg Phe Pro Leu
    50                  55                  60                  
Pro Pro Pro Leu Ala Trp Asp Ala Arg Gly Gly Ser Leu Lys Thr Phe
65                  70                  75                  80  
Arg Ala Leu Leu Thr Leu Ala Ala Gly Ala Asp Gly Pro Pro Arg Gln
                85                  90                  95      
Ser Arg Ser Glu Pro Arg Trp His Val Ser Ala Arg Gln Pro Arg Pro
            100                 105                 110         
Glu Glu Ser Ala Ala Val His Gly Gly Val Phe Trp Ser Arg Gly Leu
        115                 120                 125             
Glu Glu Gln Val Pro Pro Gly Phe Ser Glu Ala Gln Ala Ala Ala Trp
    130                 135                 140                 
Leu Glu Ala Ala Arg Gly Ala Arg Met Val Ala Leu Glu Arg Gly Gly
145                 150                 155                 160 
Cys Gly Arg Ser Ser Asn Arg Leu Ala Arg Phe Ala Asp Gly Thr Arg
                165                 170                 175     
Ala Cys Val Arg Tyr Gly Ile Asn Pro Glu Gln Ile Gln Gly Glu Ala
            180                 185                 190         
Leu Ser Tyr Tyr Leu Ala Arg Leu Leu Gly Leu Gln Arg His Val Pro
        195                 200                 205             
Pro Leu Ala Leu Ala Arg Val Glu Ala Arg Gly Ala Gln Trp Ala Gln
    210                 215                 220                 
Val Gln Glu Glu Leu Arg Ala Ala His Trp Thr Glu Gly Ser Val Val
225                 230                 235                 240 
Ser Leu Thr Arg Trp Leu Pro Asn Leu Thr Asp Val Val Val Pro Ala
                245                 250                 255     
Pro Trp Arg Ser Glu Asp Gly Arg Leu Arg Pro Leu Arg Asp Ala Gly
            260                 265                 270         
Gly Glu Leu Ala Asn Leu Ser Gln Ala Glu Leu Val Asp Leu Val Gln
        275                 280                 285             
Trp Thr Asp Leu Ile Leu Phe Asp Tyr Leu Thr Ala Asn Phe Asp Arg
    290                 295                 300                 
Leu Val Ser Asn Leu Phe Ser Leu Gln Trp Asp Pro Arg Val Met Gln
305                 310                 315                 320 
Arg Ala Thr Ser Asn Leu His Arg Gly Pro Gly Gly Ala Leu Val Phe
                325                 330                 335     
Leu Asp Asn Glu Ala Gly Leu Val His Gly Tyr Arg Val Ala Gly Met
            340                 345                 350         
Trp Asp Lys Tyr Asn Glu Pro Leu Leu Gln Ser Val Cys Val Phe Arg
        355                 360                 365             
Glu Arg Thr Ala Arg Arg Val Leu Glu Leu His Arg Gly Gln Asp Ala
    370                 375                 380                 
Ala Ala Arg Leu Leu Arg Leu Tyr Arg Arg His Glu Pro Arg Phe Pro
385                 390                 395                 400 
Glu Leu Ala Ala Leu Ala Asp Pro His Ala Gln Leu Leu Gln Arg Arg
                405                 410                 415     
Leu Asp Phe Leu Ala Lys His Ile Leu His Cys Lys Ala Lys Tyr Gly
            420                 425                 430         
Arg Arg Ser Gly Asp Leu Val Ser Pro Gly Gly Lys Glu Arg Asp Leu
        435                 440                 445             
Gly Leu Gly Tyr Gly
    450             


<210> 8726
<211> 161
<212> PRT
<213> Homo sapiens

<400> 8726
Met Val Pro Lys Leu Phe Thr Ser Gln Ile Cys Leu Leu Leu Leu Leu
 1               5                  10                  15      
Gly Leu Leu Ala Val Glu Gly Ser Leu His Val Lys Pro Pro Gln Phe
            20                  25                  30          
Thr Trp Ala Gln Trp Phe Glu Thr Gln His Ile Asn Met Thr Ser Gln
        35                  40                  45              
Gln Cys Thr Asn Ala Met Gln Val Ile Asn Asn Tyr Gln Arg Arg Cys
    50                  55                  60                  
Lys Asn Gln Asn Thr Phe Leu Leu Thr Thr Phe Ala Asn Val Val Asn
65                  70                  75                  80  
Val Cys Gly Asn Pro Asn Met Thr Cys Pro Ser Asn Lys Thr Arg Lys
                85                  90                  95      
Asn Cys His His Ser Gly Ser Gln Val Pro Leu Ile His Cys Asn Leu
            100                 105                 110         
Thr Thr Pro Ser Pro Gln Asn Ile Ser Asn Cys Arg Tyr Ala Gln Thr
        115                 120                 125             
Pro Ala Asn Met Phe Tyr Ile Val Ala Cys Asp Asn Arg Asp Gln Arg
    130                 135                 140                 
Arg Asp Pro Pro Gln Tyr Pro Val Val Pro Val His Leu Asp Arg Ile
145                 150                 155                 160 
Ile
    


<210> 8727
<211> 435
<212> PRT
<213> Homo sapiens

<400> 8727
Met Leu Leu Pro Trp Ala Thr Ser Ala Pro Gly Leu Ala Trp Gly Pro
 1               5                  10                  15      
Leu Val Leu Gly Leu Phe Gly Leu Leu Ala Ala Ser Gln Pro Gln Ala
            20                  25                  30          
Val Pro Pro Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys
        35                  40                  45              
Glu Tyr Tyr Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro
    50                  55                  60                  
Gly Thr Tyr Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys
65                  70                  75                  80  
Ala Thr Cys Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr
                85                  90                  95      
Ile Cys Gln Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu
            100                 105                 110         
Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro
        115                 120                 125             
Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu
    130                 135                 140                 
Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val
145                 150                 155                 160 
Gly Lys Gly Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln
                165                 170                 175     
Asn Thr Ser Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu
            180                 185                 190         
Asn Gln Gly Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr
        195                 200                 205             
Thr Cys Lys Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr
    210                 215                 220                 
Met Leu Met Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu
225                 230                 235                 240 
Ala Thr Val Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg
                245                 250                 255     
Lys Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn
            260                 265                 270         
Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro
        275                 280                 285             
Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val
    290                 295                 300                 
Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln
305                 310                 315                 320 
Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly
                325                 330                 335     
Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly
            340                 345                 350         
Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val
        355                 360                 365             
Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro
    370                 375                 380                 
Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser
385                 390                 395                 400 
Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu
                405                 410                 415     
His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile
            420                 425                 430         
Thr His Asp
        435 


<210> 8728
<211> 127
<212> PRT
<213> Homo sapiens

<400> 8728
Met Ala Tyr Phe Gly Gly Thr Leu Tyr Trp Leu Ile Phe Ser Thr Pro
 1               5                  10                  15      
Phe Leu Leu Leu Gly Leu Val Pro Glu Gln Ile Lys Pro Ser Val Ser
            20                  25                  30          
Gln Pro Gln Pro Ala Asn Ser Asn Asn Gly Thr Ser Thr Ala Thr Ser
        35                  40                  45              
Thr Asn Asn Asn Ala Lys Arg Ala Thr Ala Asn Asn Gln Gln Pro Gln
    50                  55                  60                  
Gln Gln Gln Gln Gln Gln Gln Pro Gln Gln Gln Gln Pro Gln Gln Gln
65                  70                  75                  80  
Pro Gln Pro Gln Pro Gln Gln Gln Gln Pro Gln Gln Gln Pro Gln Ala
                85                  90                  95      
Leu Pro Arg Tyr Pro Arg Glu Val Pro Pro Arg Phe Arg His Gln Glu
            100                 105                 110         
His Lys Gln Leu Leu Lys Arg Gly Gln His Phe Pro Val Glu Phe
        115                 120                 125         


<210> 8729
<211> 1723
<212> PRT
<213> Homo sapiens

<400> 8729
Gln Pro Cys Met Ala Ala Ala Pro Ser Ala Leu Leu Leu Leu Pro Pro
 1               5                  10                  15      
Phe Pro Val Leu Ser Thr Tyr Arg Leu Gln Ser Arg Ser Arg Pro Ser
            20                  25                  30          
Ala Pro Glu Thr Asp Asp Ser Arg Val Gly Gly Ile Met Arg Gly Glu
        35                  40                  45              
Lys Asn Tyr Tyr Phe Arg Gly Ala Ala Gly Asp His Gly Ser Cys Pro
    50                  55                  60                  
Thr Thr Thr Ser Pro Leu Ala Ser Ala Leu Leu Met Pro Ser Glu Ala
65                  70                  75                  80  
Val Ser Ser Ser Trp Ser Glu Ser Gly Gly Gly Leu Ser Gly Gly Asp
                85                  90                  95      
Glu Glu Asp Thr Arg Leu Leu Gln Leu Leu Arg Thr Ala Arg Asp Pro
            100                 105                 110         
Ser Glu Ala Phe Gln Ala Leu Gln Ala Ala Leu Pro Arg Arg Gly Gly
        115                 120                 125             
Arg Leu Gly Phe Pro Arg Arg Lys Glu Ala Leu Tyr Arg Ala Leu Gly
    130                 135                 140                 
Arg Val Leu Val Glu Gly Gly Ser Asp Glu Lys Arg Leu Cys Leu Gln
145                 150                 155                 160 
Leu Leu Ser Asp Val Leu Arg Gly Gln Gly Glu Ala Gly Gln Leu Glu
                165                 170                 175     
Glu Ala Phe Ser Leu Ala Leu Leu Pro Gln Leu Val Val Ser Leu Arg
            180                 185                 190         
Glu Glu Asn Pro Ala Leu Arg Lys Asp Ala Leu Gln Ile Leu His Ile
        195                 200                 205             
Cys Leu Lys Arg Ser Pro Gly Glu Val Leu Arg Thr Leu Ile Gln Gln
    210                 215                 220                 
Gly Leu Glu Ser Thr Asp Ala Arg Leu Arg Ala Ser Thr Ala Leu Leu
225                 230                 235                 240 
Leu Pro Ile Leu Leu Thr Thr Glu Asp Leu Leu Leu Gly Leu Asp Leu
                245                 250                 255     
Thr Glu Val Ile Ile Ser Leu Ala Arg Lys Leu Gly Asp Gln Glu Thr
            260                 265                 270         
Glu Glu Glu Ser Glu Thr Ala Phe Ser Ala Leu Gln Gln Ile Gly Glu
        275                 280                 285             
Arg Leu Gly Gln Asp Arg Phe Gln Ser Tyr Ile Ser Arg Leu Pro Ser
    290                 295                 300                 
Ala Leu Arg Arg His Tyr Asn Arg Arg Leu Glu Ser Gln Phe Gly Ser
305                 310                 315                 320 
Gln Val Pro Tyr Tyr Leu Glu Leu Glu Ala Ser Gly Phe Pro Glu Asp
                325                 330                 335     
Pro Leu Pro Cys Ala Val Thr Leu Ser Asn Ser Asn Leu Lys Phe Gly
            340                 345                 350         
Ile Ile Pro Gln Glu Leu His Ser Arg Leu Leu Asp Gln Glu Asp Tyr
        355                 360                 365             
Lys Asn Arg Thr Gln Ala Val Glu Glu Leu Lys Gln Val Leu Gly Lys
    370                 375                 380                 
Phe Asn Pro Ser Ser Thr Pro His Ser Ser Leu Val Gly Phe Ile Ser
385                 390                 395                 400 
Leu Leu Tyr Asn Leu Leu Asp Asp Ser Asn Phe Lys Val Val His Gly
                405                 410                 415     
Thr Leu Glu Val Leu His Leu Leu Val Ile Arg Leu Gly Glu Gln Val
            420                 425                 430         
Gln Gln Phe Leu Gly Pro Val Ile Ala Ala Ser Val Lys Val Leu Ala
        435                 440                 445             
Asp Asn Lys Leu Val Ile Lys Gln Glu Tyr Met Lys Ile Phe Leu Lys
    450                 455                 460                 
Leu Met Lys Glu Val Gly Pro Gln Gln Val Leu Cys Leu Leu Leu Lys
465                 470                 475                 480 
His Leu Lys His Lys His Ser Arg Val Arg Glu Glu Val Val Asn Ile
                485                 490                 495     
Cys Ile Cys Ser Leu Leu Thr Tyr Pro Ser Glu Asp Phe Asp Leu Pro
            500                 505                 510         
Lys Leu Ser Phe Asp Leu Ala Pro Ala Leu Val Asp Ser Lys Arg Arg
        515                 520                 525             
Val Arg Gln Ala Ala Leu Glu Ala Phe Ala Val Leu Ala Ser Ser Met
    530                 535                 540                 
Gly Ser Gly Lys Thr Ser Ile Leu Phe Lys Ala Val Asp Thr Val Glu
545                 550                 555                 560 
Leu Gln Asp Asn Gly Asp Gly Val Met Asn Ala Val Gln Ala Arg Leu
                565                 570                 575     
Ala Arg Lys Thr Leu Pro Arg Leu Thr Glu Gln Gly Phe Val Glu Tyr
            580                 585                 590         
Ala Val Leu Met Pro Ser Ser Ala Gly Gly Arg Ser Asn His Leu Ala
        595                 600                 605             
His Gly Ala Asp Thr Asp Trp Leu Leu Ala Gly Asn Arg Thr Gln Ser
    610                 615                 620                 
Ala His Cys His Cys Gly Asp His Val Arg Asp Ser Met His Ile Tyr
625                 630                 635                 640 
Gly Ser Tyr Ser Pro Thr Ile Cys Thr Arg Arg Val Leu Ser Ala Gly
                645                 650                 655     
Lys Gly Lys Asn Lys Leu Pro Trp Glu Asn Glu Gln Pro Gly Ile Met
            660                 665                 670         
Gly Glu Asn Gln Thr Ser Thr Ser Lys Asp Ile Glu Gln Phe Ser Thr
        675                 680                 685             
Tyr Asp Phe Ile Pro Ser Ala Lys Leu Lys Leu Ser Gln Gly Met Pro
    690                 695                 700                 
Val Asn Asp Asp Leu Cys Phe Ser Arg Lys Arg Val Ser Arg Asn Leu
705                 710                 715                 720 
Phe Gln Asn Ser Arg Asp Phe Asn Pro Asp Cys Leu Pro Leu Cys Ala
                725                 730                 735     
Ala Gly Thr Thr Gly Thr His Gln Thr Asn Leu Ser Gly Lys Cys Ala
            740                 745                 750         
Gln Leu Gly Phe Ser Gln Ile Cys Gly Lys Thr Gly Ser Val Gly Ser
        755                 760                 765             
Asp Leu Gln Phe Leu Gly Thr Thr Ser Ser His Gln Glu Lys Val Tyr
    770                 775                 780                 
Ala Ser Leu Asn Phe Gly Ser Lys Thr Gln Gln Thr Phe Gly Ser Gln
785                 790                 795                 800 
Thr Glu Cys Thr Ser Ser Asn Gly Gln Asn Pro Ser Pro Gly Ala Tyr
                805                 810                 815     
Ile Leu Pro Ser Tyr Pro Val Ser Ser Pro Arg Thr Ser Pro Lys His
            820                 825                 830         
Thr Ser Pro Leu Ile Ile Ser Pro Lys Lys Ser Gln Asp Asn Ser Val
        835                 840                 845             
Asn Phe Ser Asn Ser Trp Pro Leu Lys Ser Phe Glu Gly Leu Ser Lys
    850                 855                 860                 
Pro Ser Pro Gln Lys Lys Leu Val Ser Gln Lys Ser Ser Asp Pro Thr
865                 870                 875                 880 
Gly Arg Asn His Gly Glu Asn Ser Gln Glu Lys Pro Pro Val Gln Leu
                885                 890                 895     
Thr Pro Ala Leu Val Arg Ser Pro Ser Ser Arg Arg Gly Leu Asn Gly
            900                 905                 910         
Thr Lys Pro Val Pro Pro Ile Pro Arg Gly Ile Ser Leu Leu Pro Asp
        915                 920                 925             
Lys Ala Asp Leu Ser Thr Val Gly His Lys Lys Lys Glu Pro Asp Asp
    930                 935                 940                 
Ile Trp Lys Cys Glu Lys Asp Ser Leu Pro Ile Asp Leu Ser Glu Leu
945                 950                 955                 960 
Asn Phe Lys Asp Lys Asp Leu Asp Gln Glu Glu Met His Ser Ser Leu
                965                 970                 975     
Arg Ser Leu Arg Asn Ser Ala Ala Lys Lys Arg Ala Lys Leu Ser Gly
            980                 985                 990         
Ser Thr Leu Asp Leu Glu Ser Pro Asp Ser Ala Met Lys Leu Asp Leu
        995                 1000                1005            
Thr Met Asp Ser Pro Ser Leu Ser Ser Ser Pro Asn Ile Asn Ser Tyr
    1010                1015                1020                
Ser Glu Ser Gly Val Tyr Ser Gln Glu Ser Leu Thr Ser Ser Leu Ser
1025                1030                1035                1040
Thr Thr Pro Gln Gly Lys Arg Ile Met Ser Asp Ile Phe Pro Thr Phe
                1045                1050                1055    
Gly Ser Lys Pro Cys Pro Thr Arg Leu Ser Ser Ala Lys Lys Lys Ile
            1060                1065                1070        
Ser His Ile Ala Glu Gln Ser Pro Ser Ala Gly Ser Ser Ser Asn Pro
        1075                1080                1085            
Gln Gln Ile Ser Ser Phe Asp Phe Thr Thr Thr Lys Ala Leu Ser Glu
    1090                1095                1100                
Asp Ser Val Val Val Val Gly Lys Gly Val Phe Gly Ser Leu Ser Ser
1105                1110                1115                1120
Ala Pro Ala Thr Cys Ser Gln Ser Val Ile Ser Ser Val Glu Asn Gly
                1125                1130                1135    
Asp Thr Phe Ser Ile Lys Gln Ser Ile Glu Pro Pro Ser Gly Ile Tyr
            1140                1145                1150        
Gly Arg Ser Val Gln Gln Asn Ile Ser Ser Tyr Leu Asp Val Glu Asn
        1155                1160                1165            
Glu Lys Asp Ala Lys Val Ser Ile Ser Lys Ser Thr Tyr Asn Lys Met
    1170                1175                1180                
Arg Gln Lys Arg Lys Glu Glu Lys Glu Leu Phe His Asn Lys Asp Cys
1185                1190                1195                1200
Glu Lys Lys Glu Lys Asn Ser Trp Glu Arg Met Arg His Thr Gly Thr
                1205                1210                1215    
Glu Lys Met Ala Ser Glu Ser Glu Thr Pro Thr Gly Ala Ile Ser Gln
            1220                1225                1230        
Tyr Lys Glu Arg Met Pro Ser Val Thr His Ser Pro Glu Ile Met Asp
        1235                1240                1245            
Leu Ser Glu Leu Arg Pro Phe Ser Lys Pro Glu Ile Ala Leu Thr Glu
    1250                1255                1260                
Ala Leu Arg Leu Leu Ala Asp Glu Asp Trp Glu Lys Lys Ile Glu Gly
1265                1270                1275                1280
Leu Asn Phe Ile Arg Cys Leu Ala Ala Phe His Ser Glu Ile Leu Asn
                1285                1290                1295    
Thr Lys Leu His Glu Thr Asn Phe Ala Val Val Gln Glu Val Lys Asn
            1300                1305                1310        
Leu Arg Ser Gly Val Ser Arg Ala Ala Val Val Cys Leu Ser Asp Leu
        1315                1320                1325            
Phe Thr Tyr Leu Lys Lys Ser Met Asp Gln Glu Leu Asp Thr Thr Val
    1330                1335                1340                
Lys Val Leu Leu His Lys Ala Gly Glu Ser Asn Thr Phe Ile Arg Glu
1345                1350                1355                1360
Asp Val Asp Lys Ala Leu Arg Ala Met Val Asn Asn Val Thr Pro Ala
                1365                1370                1375    
Arg Ala Val Val Ser Leu Ile Asn Gly Gly Gln Arg Tyr Tyr Gly Arg
            1380                1385                1390        
Lys Met Leu Phe Phe Met Met Cys His Pro Asn Phe Glu Lys Met Leu
        1395                1400                1405            
Glu Lys Tyr Val Pro Ser Lys Asp Leu Pro Tyr Ile Lys Asp Ser Val
    1410                1415                1420                
Arg Asn Leu Gln Gln Lys Gly Leu Gly Glu Ile Pro Leu Asp Thr Pro
1425                1430                1435                1440
Ser Ala Lys Gly Arg Arg Ser His Thr Gly Ser Val Gly Asn Thr Arg
                1445                1450                1455    
Ser Ser Ser Val Ser Arg Asp Ala Phe Asn Ser Ala Glu Arg Ala Val
            1460                1465                1470        
Thr Glu Val Arg Glu Val Thr Arg Lys Ser Val Pro Arg Asn Ser Leu
        1475                1480                1485            
Glu Ser Ala Glu Tyr Leu Lys Leu Ile Thr Gly Leu Leu Asn Ala Lys
    1490                1495                1500                
Asp Phe Arg Asp Arg Ile Asn Gly Ile Lys Gln Leu Leu Ser Asp Thr
1505                1510                1515                1520
Glu Asn Asn Gln Asp Leu Val Val Gly Asn Ile Val Lys Ile Phe Asp
                1525                1530                1535    
Ala Phe Lys Ser Arg Leu His Asp Ser Asn Ser Lys Val Asn Leu Val
            1540                1545                1550        
Ala Leu Glu Thr Met His Lys Met Ile Pro Leu Leu Arg Asp His Leu
        1555                1560                1565            
Ser Pro Ile Ile Asn Met Leu Ile Pro Ala Ile Val Asp Asn Asn Leu
    1570                1575                1580                
Asn Ser Lys Asn Pro Gly Ile Tyr Ala Ala Ala Thr Asn Val Val Gln
1585                1590                1595                1600
Ala Leu Ser Gln His Val Asp Asn Tyr Leu Leu Leu Gln Pro Phe Cys
                1605                1610                1615    
Thr Lys Ala Gln Phe Leu Asn Gly Lys Ala Lys Gln Asp Met Thr Glu
            1620                1625                1630        
Lys Leu Ala Asp Ile Val Thr Glu Leu Tyr Gln Arg Lys Pro His Ala
        1635                1640                1645            
Thr Glu Gln Lys Val Leu Val Val Leu Trp His Leu Leu Gly Asn Met
    1650                1655                1660                
Thr Asn Ser Gly Ser Leu Pro Gly Ala Gly Gly Asn Ile Arg Thr Ala
1665                1670                1675                1680
Thr Ala Lys Leu Ser Lys Ala Leu Phe Ala Gln Met Gly Gln Asn Leu
                1685                1690                1695    
Leu Asn Gln Ala Ala Ser Gln Pro Pro His Ile Lys Lys Ser Leu Glu
            1700                1705                1710        
Glu Leu Leu Asp Met Thr Ile Leu Asn Glu Leu
        1715                1720            


<210> 8730
<211> 587
<212> PRT
<213> Homo sapiens

<400> 8730
Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr Leu Ala Lys Thr
 1               5                  10                  15      
Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys Ser Leu Lys Leu
            20                  25                  30          
Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu Ile Glu Asp Phe
        35                  40                  45              
Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr Val Gly Val Glu
    50                  55                  60                  
Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys Ser Glu Leu Lys
65                  70                  75                  80  
Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu Arg Thr Glu Ile
                85                  90                  95      
Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile Thr Ala Gly Ala
            100                 105                 110         
Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe Gly Pro Asp Gly
        115                 120                 125             
Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser Ala Cys Phe Thr Leu
    130                 135                 140                 
Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile Gly Gly Gly Lys
145                 150                 155                 160 
Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys Ser Ser Ala Gln
                165                 170                 175     
Gly Lys Pro Leu Ala Leu Lys Val Phe Val Ala Gly Arg Asn Arg Leu
            180                 185                 190         
Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe Arg Val Ile Gly
        195                 200                 205             
Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile Asn His Pro Gly
    210                 215                 220                 
Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro Leu Leu Arg Val
225                 230                 235                 240 
Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly Ala Val Ala Met
                245                 250                 255     
Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val Ile Asn Phe Gly
            260                 265                 270         
Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile Ala Asp Ala Ile
        275                 280                 285             
Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu Ser Phe Cys Glu
    290                 295                 300                 
Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala Met Ala Asp Lys
305                 310                 315                 320 
Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr Leu Gly Glu Glu
                325                 330                 335     
Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe Asn Met Ala Lys
            340                 345                 350         
Val Leu Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu Glu Glu Glu Glu
        355                 360                 365             
Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Asp Glu
    370                 375                 380                 
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Gln Gln
385                 390                 395                 400 
Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg Lys Ile Leu Asp
                405                 410                 415     
Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser Pro Pro Pro Ala
            420                 425                 430         
Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu Lys Leu Leu Arg
        435                 440                 445             
Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln Thr Asp Thr Ser
    450                 455                 460                 
Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val Ser Ser Val Phe
465                 470                 475                 480 
Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp Ala Val Asp Ala
                485                 490                 495     
Leu Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn Ser Asn Thr Phe
            500                 505                 510         
Leu Thr Arg Leu Leu Val His Met Gly Leu Leu Lys Ser Glu Asp Lys
        515                 520                 525             
Val Lys Ala Ile Ala Asn Leu Tyr Gly Pro Leu Met Ala Leu Asn His
    530                 535                 540                 
Met Val Gln Gln Asp Tyr Phe Pro Lys Ala Leu Ala Pro Leu Leu Leu
545                 550                 555                 560 
Ala Phe Val Thr Lys Pro Asn Ser Ala Leu Glu Ser Cys Ser Phe Ala
                565                 570                 575     
Arg His Ser Leu Leu Gln Thr Leu Tyr Lys Val
            580                 585         


<210> 8731
<211> 623
<212> PRT
<213> Homo sapiens

<400> 8731
Cys Pro Thr Leu Pro Pro Thr Arg Gly Pro Arg Arg Leu Leu Phe Leu
 1               5                  10                  15      
Thr Ala Thr Leu Ala Ser Ser Val Cys Arg Ser Pro Gly Glu Pro Thr
            20                  25                  30          
Ser Leu Val Asn Met Ala Ser Glu Asp Ile Ala Lys Leu Ala Glu Thr
        35                  40                  45              
Leu Ala Lys Thr Gln Val Ala Gly Gly Gln Leu Ser Phe Lys Gly Lys
    50                  55                  60                  
Ser Leu Lys Leu Asn Thr Ala Glu Asp Ala Lys Asp Val Ile Lys Glu
65                  70                  75                  80  
Ile Glu Asp Phe Asp Ser Leu Glu Ala Leu Arg Leu Glu Gly Asn Thr
                85                  90                  95      
Val Gly Val Glu Ala Ala Arg Val Ile Ala Lys Ala Leu Glu Lys Lys
            100                 105                 110         
Ser Glu Leu Lys Arg Cys His Trp Ser Asp Met Phe Thr Gly Arg Leu
        115                 120                 125             
Arg Thr Glu Ile Pro Pro Ala Leu Ile Ser Leu Gly Glu Gly Leu Ile
    130                 135                 140                 
Thr Ala Gly Ala Gln Leu Val Glu Leu Asp Leu Ser Asp Asn Ala Phe
145                 150                 155                 160 
Gly Pro Asp Gly Val Gln Gly Phe Glu Ala Leu Leu Lys Ser Ser Ala
                165                 170                 175     
Cys Phe Thr Leu Gln Glu Leu Lys Leu Asn Asn Cys Gly Met Gly Ile
            180                 185                 190         
Gly Gly Gly Lys Ile Leu Ala Ala Ala Leu Thr Glu Cys His Arg Lys
        195                 200                 205             
Ser Ser Ala Gln Gly Lys Pro Leu Ala Leu Lys Val Phe Val Ala Gly
    210                 215                 220                 
Arg Asn Arg Leu Glu Asn Asp Gly Ala Thr Ala Leu Ala Glu Ala Phe
225                 230                 235                 240 
Arg Val Ile Gly Thr Leu Glu Glu Val His Met Pro Gln Asn Gly Ile
                245                 250                 255     
Asn His Pro Gly Ile Thr Ala Leu Ala Gln Ala Phe Ala Val Asn Pro
            260                 265                 270         
Leu Leu Arg Val Ile Asn Leu Asn Asp Asn Thr Phe Thr Glu Lys Gly
        275                 280                 285             
Ala Val Ala Met Ala Glu Thr Leu Lys Thr Leu Arg Gln Val Glu Val
    290                 295                 300                 
Ile Asn Phe Gly Asp Cys Leu Val Arg Ser Lys Gly Ala Val Ala Ile
305                 310                 315                 320 
Ala Asp Ala Ile Arg Gly Gly Leu Pro Lys Leu Lys Glu Leu Asn Leu
                325                 330                 335     
Ser Phe Cys Glu Ile Lys Arg Asp Ala Ala Leu Ala Val Ala Glu Ala
            340                 345                 350         
Met Ala Asp Lys Ala Glu Leu Glu Lys Leu Asp Leu Asn Gly Asn Thr
        355                 360                 365             
Leu Gly Glu Glu Gly Cys Glu Gln Leu Gln Glu Val Leu Glu Gly Phe
    370                 375                 380                 
Asn Met Ala Lys Val Leu Ala Ser Leu Ser Asp Asp Glu Asp Glu Glu
385                 390                 395                 400 
Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu
                405                 410                 415     
Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
            420                 425                 430         
Glu Pro Gln Gln Arg Gly Gln Gly Glu Lys Ser Ala Thr Pro Ser Arg
        435                 440                 445             
Lys Ile Leu Asp Pro Asn Thr Gly Glu Pro Ala Pro Val Leu Ser Ser
    450                 455                 460                 
Pro Pro Pro Ala Asp Val Ser Thr Phe Leu Ala Phe Pro Ser Pro Glu
465                 470                 475                 480 
Lys Leu Leu Arg Leu Gly Pro Lys Ser Ser Val Leu Ile Ala Gln Gln
                485                 490                 495     
Thr Asp Thr Ser Asp Pro Glu Lys Val Val Ser Ala Phe Leu Lys Val
            500                 505                 510         
Ser Ser Val Phe Lys Asp Glu Ala Thr Val Arg Met Ala Val Gln Asp
        515                 520                 525             
Ala Val Asp Ala Leu Met Gln Lys Ala Phe Asn Ser Ser Ser Phe Asn
    530                 535                 540                 
Ser Asn Thr Phe Leu Thr Arg Leu Leu Val His Met Gly Leu Leu Lys
545                 550                 555                 560 
Ser Glu Asp Lys Val Lys Ala Ile Ala Asn Leu Tyr Gly Pro Leu Met
                565                 570                 575     
Ala Leu Asn His Met Val Gln Gln Asp Tyr Phe Pro Lys Ala Leu Ala
            580                 585                 590         
Pro Leu Leu Leu Ala Phe Val Thr Lys Pro Asn Ser Ala Leu Glu Ser
        595                 600                 605             
Cys Ser Phe Ala Arg His Ser Leu Leu Gln Thr Leu Tyr Lys Val
    610                 615                 620             


<210> 8732
<211> 402
<212> PRT
<213> Homo sapiens

<400> 8732
Met Ala Ala Arg Pro Gly Pro Leu Trp Leu Leu Gly Leu Thr Leu Cys
 1               5                  10                  15      
Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro
            20                  25                  30          
Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile
        35                  40                  45              
Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro
    50                  55                  60                  
Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu
65                  70                  75                  80  
Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu
                85                  90                  95      
Gln Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val
            100                 105                 110         
Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe
        115                 120                 125             
Arg Phe Asp Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala
    130                 135                 140                 
Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Thr
145                 150                 155                 160 
Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu
                165                 170                 175     
Ser Asp Leu Phe Phe Leu Asp Leu Gln Thr Leu Arg Ala Gly Asp Glu
            180                 185                 190         
Gly Trp Leu Val Leu Asp Val Thr Ala Ala Ser Asp Cys Trp Leu Leu
        195                 200                 205             
Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Glu Asp
    210                 215                 220                 
Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala
225                 230                 235                 240 
Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg Ala Ser Pro
                245                 250                 255     
Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln
            260                 265                 270         
Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile
        275                 280                 285             
Phe Asp Asp Val His Gly Ser His Gly Arg Gln Val Cys Arg Arg His
    290                 295                 300                 
Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile
305                 310                 315                 320 
Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe
                325                 330                 335     
Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser
            340                 345                 350         
Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala Cys Cys Ala
        355                 360                 365             
Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp Ser Ser Asn
    370                 375                 380                 
Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly
385                 390                 395                 400 
Cys His
        


<210> 8733
<211> 402
<212> PRT
<213> Homo sapiens

<400> 8733
Met Thr Ala Leu Pro Gly Pro Leu Trp Leu Leu Gly Leu Ala Leu Cys
 1               5                  10                  15      
Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro
            20                  25                  30          
Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile
        35                  40                  45              
Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro
    50                  55                  60                  
Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu
65                  70                  75                  80  
Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu
                85                  90                  95      
Arg Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val
            100                 105                 110         
Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe
        115                 120                 125             
Arg Phe Asp Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala
    130                 135                 140                 
Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Thr
145                 150                 155                 160 
Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu
                165                 170                 175     
Ser Asp Leu Phe Phe Leu Asp Leu Gln Thr Leu Arg Ala Gly Asp Glu
            180                 185                 190         
Gly Trp Leu Val Leu Asp Val Thr Ala Ala Ser Asp Cys Trp Leu Leu
        195                 200                 205             
Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Glu Asp
    210                 215                 220                 
Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala
225                 230                 235                 240 
Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg Ala Ser Pro
                245                 250                 255     
Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln
            260                 265                 270         
Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile
        275                 280                 285             
Phe Asp Asp Val His Gly Ser His Gly Arg Gln Val Cys Arg Arg His
    290                 295                 300                 
Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile
305                 310                 315                 320 
Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe
                325                 330                 335     
Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser
            340                 345                 350         
Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala Cys Cys Ala
        355                 360                 365             
Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp Ser Ser Asn
    370                 375                 380                 
Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly
385                 390                 395                 400 
Cys His
        


<210> 8734
<211> 412
<212> PRT
<213> Homo sapiens

<400> 8734
Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn
 1               5                  10                  15      
Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu
            20                  25                  30          
Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr
        35                  40                  45              
Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg
    50                  55                  60                  
Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser
65                  70                  75                  80  
Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly
                85                  90                  95      
Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu
            100                 105                 110         
Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala
        115                 120                 125             
Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr
    130                 135                 140                 
Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu
145                 150                 155                 160 
Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro
                165                 170                 175     
Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln
            180                 185                 190         
Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala
        195                 200                 205             
Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr
    210                 215                 220                 
Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu
225                 230                 235                 240 
Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu
                245                 250                 255     
Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu
            260                 265                 270         
Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val
        275                 280                 285             
Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser
    290                 295                 300                 
Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys
305                 310                 315                 320 
Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val
                325                 330                 335     
Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr
            340                 345                 350         
Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu
        355                 360                 365             
Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu
    370                 375                 380                 
Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg
385                 390                 395                 400 
Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro
                405                 410         


<210> 8735
<211> 4599
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 4343
<223> Xaa = Any Amino Acid

<400> 8735
Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro
 1               5                  10                  15      
Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys
            20                  25                  30          
Asp Pro Gly Glu Phe Leu Cys His Asp His Val Thr Cys Val Ser Gln
        35                  40                  45              
Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu
    50                  55                  60                  
Ser Leu Asp Thr Cys Pro Glu Glu Val Glu Ile Lys Cys Pro Leu Asn
65                  70                  75                  80  
His Ile Ala Cys Leu Gly Thr Asn Lys Cys Val His Leu Ser Gln Leu
                85                  90                  95      
Cys Asn Gly Val Leu Asp Cys Pro Asp Gly Tyr Asp Glu Gly Val His
            100                 105                 110         
Cys Gln Glu Leu Leu Ser Asn Cys Gln Gln Leu Asn Cys Gln Tyr Lys
        115                 120                 125             
Cys Thr Met Val Arg Asn Ser Thr Arg Cys Tyr Cys Glu Asp Gly Phe
    130                 135                 140                 
Glu Ile Thr Glu Asp Gly Arg Ser Cys Lys Asp Gln Asp Glu Cys Ala
145                 150                 155                 160 
Val Tyr Gly Thr Cys Ser Gln Thr Cys Arg Asn Thr His Gly Ser Tyr
                165                 170                 175     
Thr Cys Ser Cys Val Glu Gly Tyr Leu Met Gln Pro Asp Asn Arg Ser
            180                 185                 190         
Cys Lys Ala Lys Ile Glu Pro Thr Asp Arg Pro Pro Ile Leu Leu Ile
        195                 200                 205             
Ala Asn Phe Glu Thr Ile Glu Val Phe Tyr Leu Asn Gly Ser Lys Met
    210                 215                 220                 
Ala Thr Leu Ser Ser Val Asn Gly Asn Glu Ile His Thr Leu Asp Phe
225                 230                 235                 240 
Ile Tyr Asn Glu Asp Met Ile Cys Trp Ile Glu Ser Arg Glu Ser Ser
                245                 250                 255     
Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr Asp
            260                 265                 270         
Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His Asn Val Gln Gln Met
        275                 280                 285             
Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val Gly
    290                 295                 300                 
Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr Leu
305                 310                 315                 320 
Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile Ala Val Asp Pro Ile
                325                 330                 335     
Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val Glu
            340                 345                 350         
Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg Ile Ile Asp Ser Lys
        355                 360                 365             
Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu Val
    370                 375                 380                 
Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr Gln
385                 390                 395                 400 
Gly Lys Asn Arg His Thr Val Ile Gln Gly Arg Gln Val Arg His Leu
                405                 410                 415     
Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser Asp
            420                 425                 430         
Asn Tyr Asn Ile Val Arg Ile Asn Arg Phe Asn Gly Thr Asp Ile His
        435                 440                 445             
Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln Lys
    450                 455                 460                 
Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys Glu Val Asp Pro Tyr
465                 470                 475                 480 
Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu Leu Ser Ser Ser Tyr
                485                 490                 495     
Lys Thr Arg Thr Cys Arg Cys Arg Thr Gly Phe Asn Leu Gly Ser Asp
            500                 505                 510         
Gly Arg Ser Cys Lys Arg Pro Lys Asn Glu Leu Phe Leu Phe Tyr Gly
        515                 520                 525             
Lys Gly Arg Pro Gly Ile Val Arg Gly Met Asp Leu Asn Thr Lys Ile
    530                 535                 540                 
Ala Asp Glu Tyr Met Ile Pro Ile Glu Asn Leu Val Asn Pro Arg Ala
545                 550                 555                 560 
Leu Asp Phe His Ala Glu Thr Asn Tyr Ile Tyr Phe Ala Asp Thr Thr
                565                 570                 575     
Ser Phe Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu Arg Glu Thr
            580                 585                 590         
Ile Leu Lys Asp Asp Leu Asp Asn Val Glu Gly Ile Ala Val Asp Trp
        595                 600                 605             
Ile Gly Asn Asn Leu Tyr Trp Thr Asn Asp Gly His Arg Lys Thr Ile
    610                 615                 620                 
Asn Val Ala Arg Leu Glu Lys Ala Ser Gln Ser Arg Lys Thr Leu Leu
625                 630                 635                 640 
Glu Gly Glu Met Ser His Pro Arg Gly Ile Val Val Asp Pro Val Asn
                645                 650                 655     
Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Glu Ile Asp Asp Ser
            660                 665                 670         
Val Gly Arg Ile Glu Lys Ala Trp Met Asp Gly Phe Asn Arg Gln Ile
        675                 680                 685             
Phe Val Thr Ser Lys Met Leu Trp Pro Asn Gly Leu Thr Leu Asp Phe
    690                 695                 700                 
His Thr Asn Thr Leu Tyr Trp Cys Asp Ala Tyr Tyr Asp His Ile Glu
705                 710                 715                 720 
Lys Val Phe Leu Asn Gly Thr His Arg Lys Ile Val Tyr Ser Gly Arg
                725                 730                 735     
Glu Leu Asn His Pro Phe Gly Leu Ser His His Gly Asn Tyr Val Phe
            740                 745                 750         
Trp Thr Asp Tyr Met Asn Gly Ser Ile Phe Gln Leu Asp Leu Ile Thr
        755                 760                 765             
Ser Glu Val Thr Leu Leu Arg His Glu Arg Pro Pro Leu Phe Gly Leu
    770                 775                 780                 
Gln Ile Tyr Asp Pro Arg Lys Gln Gln Gly Asp Asn Met Cys Arg Val
785                 790                 795                 800 
Asn Asn Gly Gly Cys Ser Thr Leu Cys Leu Ala Ile Pro Gly Gly Arg
                805                 810                 815     
Val Cys Ala Cys Ala Asp Asn Gln Leu Leu Asp Glu Asn Gly Thr Thr
            820                 825                 830         
Cys Thr Phe Asn Pro Gly Glu Ala Leu Pro His Ile Cys Lys Ala Gly
        835                 840                 845             
Glu Phe Arg Cys Lys Asn Arg His Cys Ile Gln Ala Arg Trp Lys Cys
    850                 855                 860                 
Asp Gly Asp Asp Asp Cys Leu Asp Gly Ser Asp Glu Asp Ser Val Asn
865                 870                 875                 880 
Cys Phe Asn His Ser Cys Pro Asp Asp Gln Phe Lys Cys Gln Asn Asn
                885                 890                 895     
Arg Cys Ile Pro Lys Arg Trp Leu Cys Asp Gly Ala Asn Asp Cys Gly
            900                 905                 910         
Ser Asn Glu Asp Glu Ser Asn Gln Thr Cys Thr Ala Arg Thr Cys Gln
        915                 920                 925             
Val Asp Gln Phe Ser Cys Gly Asn Gly Arg Cys Ile Pro Arg Ala Trp
    930                 935                 940                 
Leu Cys Asp Arg Glu Asp Asp Cys Gly Asp Gln Thr Asp Glu Met Ala
945                 950                 955                 960 
Ser Cys Glu Phe Pro Thr Cys Glu Pro Leu Thr Gln Phe Val Cys Lys
                965                 970                 975     
Ser Gly Arg Cys Ile Ser Ser Lys Trp His Cys Asp Ser Asp Asp Asp
            980                 985                 990         
Cys Gly Asp Gly Ser Asp Glu Val Gly Cys Val His Ser Cys Phe Asp
        995                 1000                1005            
Asn Gln Phe Arg Cys Ser Ser Gly Arg Cys Ile Pro Gly His Trp Ala
    1010                1015                1020                
Cys Asp Gly Asp Asn Asp Cys Gly Asp Phe Ser Asp Glu Ala Gln Ile
1025                1030                1035                1040
Asn Cys Thr Lys Glu Glu Ile His Ser Pro Ala Gly Cys Asn Gly Asn
                1045                1050                1055    
Glu Phe Gln Cys His Pro Asp Gly Asn Cys Val Pro Asp Leu Trp Arg
            1060                1065                1070        
Cys Asp Gly Glu Lys Asp Cys Glu Asp Gly Ser Asp Glu Lys Gly Cys
        1075                1080                1085            
Asn Gly Thr Ile Arg Leu Cys Asp His Lys Thr Lys Phe Ser Cys Trp
    1090                1095                1100                
Ser Thr Gly Arg Cys Ile Asn Lys Ala Trp Val Cys Asp Gly Asp Ile
1105                1110                1115                1120
Asp Cys Glu Asp Gln Ser Asp Glu Asp Asp Cys Asp Ser Phe Leu Cys
                1125                1130                1135    
Gly Pro Pro Lys His Pro Cys Ala Asn Asp Thr Ser Val Cys Leu Gln
            1140                1145                1150        
Pro Glu Lys Leu Cys Asn Gly Lys Lys Asp Cys Pro Asp Gly Ser Asp
        1155                1160                1165            
Glu Gly Tyr Leu Cys Asp Glu Cys Ser Leu Asn Asn Gly Gly Cys Ser
    1170                1175                1180                
Asn His Cys Ser Val Val Pro Gly Arg Gly Ile Val Cys Ser Cys Pro
1185                1190                1195                1200
Glu Gly Leu Gln Leu Asn Lys Asp Asn Lys Thr Cys Glu Ile Val Asp
                1205                1210                1215    
Tyr Cys Ser Asn His Leu Lys Cys Ser Gln Val Cys Glu Gln His Lys
            1220                1225                1230        
His Thr Val Lys Cys Ser Cys Tyr Glu Gly Trp Lys Leu Asp Val Asp
        1235                1240                1245            
Gly Glu Ser Cys Thr Ser Val Asp Pro Phe Glu Ala Phe Ile Ile Phe
    1250                1255                1260                
Ser Ile Arg His Glu Ile Arg Arg Ile Asp Leu His Lys Arg Asp Tyr
1265                1270                1275                1280
Ser Leu Leu Val Pro Gly Leu Arg Asn Thr Ile Ala Leu Asp Phe His
                1285                1290                1295    
Phe Asn Gln Ser Leu Leu Tyr Trp Thr Asp Val Val Glu Asp Arg Ile
            1300                1305                1310        
Tyr Arg Gly Lys Leu Ser Glu Ser Gly Gly Val Ser Ala Ile Glu Val
        1315                1320                1325            
Val Val Glu His Gly Leu Ala Thr Pro Glu Gly Leu Thr Val Asp Trp
    1330                1335                1340                
Ile Ala Gly Asn Ile Tyr Trp Ile Asp Ser Asn Leu Asp Gln Ile Glu
1345                1350                1355                1360
Val Ala Lys Leu Asp Gly Ser Leu Arg Thr Thr Leu Ile Ala Gly Ala
                1365                1370                1375    
Met Glu His Pro Arg Ala Ile Ala Leu Asp Pro Arg Tyr Gly Ile Leu
            1380                1385                1390        
Phe Trp Thr Asp Trp Asp Ala Asn Phe Pro Arg Ile Glu Ser Ala Ser
        1395                1400                1405            
Met Ser Gly Ala Gly Arg Lys Thr Ile Tyr Lys Asp Met Lys Thr Gly
    1410                1415                1420                
Ala Trp Pro Asn Gly Leu Thr Val Asp His Phe Glu Lys Arg Ile Val
1425                1430                1435                1440
Trp Thr Asp Ala Arg Ser Asp Ala Ile Tyr Ser Ala Leu Tyr Asp Gly
                1445                1450                1455    
Thr Asn Met Ile Glu Ile Ile Arg Gly His Glu Tyr Leu Ser His Pro
            1460                1465                1470        
Phe Ala Val Ser Leu Tyr Gly Ser Glu Val Tyr Trp Thr Asp Trp Arg
        1475                1480                1485            
Thr Asn Thr Leu Ser Lys Ala Asn Lys Trp Thr Gly Gln Asn Val Ser
    1490                1495                1500                
Val Ile Gln Lys Thr Ser Ala Gln Pro Phe Asp Leu Gln Ile Tyr His
1505                1510                1515                1520
Pro Ser Arg Gln Pro Gln Ala Pro Asn Pro Cys Ala Ala Asn Asp Gly
                1525                1530                1535    
Lys Gly Pro Cys Ser His Met Cys Leu Ile Asn His Asn Arg Ser Ala
            1540                1545                1550        
Ala Cys Ala Cys Pro His Leu Met Lys Leu Ser Ser Asp Lys Lys Thr
        1555                1560                1565            
Cys Tyr Glu Met Lys Lys Phe Leu Leu Tyr Ala Arg Arg Ser Glu Ile
    1570                1575                1580                
Arg Gly Val Asp Ile Asp Asn Pro Tyr Phe Asn Phe Ile Thr Ala Phe
1585                1590                1595                1600
Thr Val Pro Asp Ile Asp Asp Val Thr Val Ile Asp Phe Asp Ala Ser
                1605                1610                1615    
Glu Glu Arg Leu Tyr Trp Thr Asp Ile Lys Thr Gln Thr Ile Lys Arg
            1620                1625                1630        
Ala Phe Ile Asn Gly Thr Gly Leu Glu Thr Val Ile Ser Arg Asp Ile
        1635                1640                1645            
Gln Ser Ile Arg Gly Leu Ala Val Asp Trp Val Ser Arg Asn Leu Tyr
    1650                1655                1660                
Trp Ile Ser Ser Glu Phe Asp Glu Thr Gln Ile Asn Val Ala Arg Leu
1665                1670                1675                1680
Asp Gly Ser Leu Lys Thr Ser Ile Ile His Gly Ile Asp Lys Pro Gln
                1685                1690                1695    
Cys Leu Ala Ala His Pro Val Arg Gly Lys Leu Tyr Trp Thr Asp Gly
            1700                1705                1710        
Asn Thr Ile Asn Met Ala Asn Met Asp Gly Ser Asn Ser Lys Ile Leu
        1715                1720                1725            
Phe Gln Asn Gln Lys Glu Pro Val Gly Leu Ser Ile Asp Tyr Val Glu
    1730                1735                1740                
Asn Lys Leu Tyr Trp Ile Ser Ser Gly Asn Gly Thr Ile Asn Arg Cys
1745                1750                1755                1760
Asn Leu Asp Gly Gly Asn Leu Glu Val Ile Glu Ser Met Lys Glu Glu
                1765                1770                1775    
Leu Thr Lys Ala Thr Ala Leu Thr Ile Met Asp Lys Lys Leu Trp Trp
            1780                1785                1790        
Ala Asp Gln Asn Leu Ala Gln Leu Gly Thr Cys Ser Lys Arg Asp Gly
        1795                1800                1805            
Arg Asn Pro Thr Ile Leu Arg Asn Lys Thr Ser Gly Val Val His Met
    1810                1815                1820                
Lys Val Tyr Asp Lys Glu Ala Gln Gln Gly Ser Asn Ser Cys Gln Leu
1825                1830                1835                1840
Asn Asn Gly Gly Cys Ser Gln Leu Cys Leu Pro Thr Ser Glu Thr Thr
                1845                1850                1855    
Arg Thr Cys Met Cys Thr Val Gly Tyr Tyr Leu Gln Lys Asn Arg Met
            1860                1865                1870        
Ser Cys Gln Gly Ile Glu Ser Phe Leu Met Tyr Ser Val His Glu Gly
        1875                1880                1885            
Ile Arg Gly Ile Pro Leu Glu Pro Ser Asp Lys Met Asp Ala Leu Met
    1890                1895                1900                
Pro Ile Ser Gly Thr Ser Phe Ala Val Gly Ile Asp Phe His Ala Glu
1905                1910                1915                1920
Asn Asp Thr Ile Tyr Trp Thr Asp Met Gly Phe Asn Lys Ile Ser Arg
                1925                1930                1935    
Ala Lys Arg Asp Gln Thr Trp Lys Glu Asp Ile Ile Thr Asn Gly Leu
            1940                1945                1950        
Gly Arg Val Glu Gly Ile Ala Val Asp Trp Ile Ala Gly Asn Ile Tyr
        1955                1960                1965            
Trp Thr Asp His Gly Phe Asn Leu Ile Glu Val Ala Arg Leu Asn Gly
    1970                1975                1980                
Ser Phe Arg Tyr Val Ile Ile Ser Gln Gly Leu Asp Gln Pro Arg Ser
1985                1990                1995                2000
Ile Ala Val His Pro Glu Lys Gly Leu Leu Phe Trp Thr Glu Trp Gly
                2005                2010                2015    
Gln Met Pro Cys Ile Gly Lys Ala Arg Leu Asp Gly Ser Glu Lys Val
            2020                2025                2030        
Val Leu Val Ser Met Gly Ile Ala Trp Pro Asn Gly Ile Ser Ile Asp
        2035                2040                2045            
Tyr Glu Glu Asn Lys Leu Tyr Trp Cys Asp Ala Arg Thr Asp Lys Ile
    2050                2055                2060                
Glu Arg Ile Asp Leu Glu Thr Gly Gly Asn Arg Glu Met Val Leu Ser
2065                2070                2075                2080
Gly Ser Asn Val Asp Met Phe Ser Val Ala Val Phe Gly Ala Tyr Ile
                2085                2090                2095    
Tyr Trp Ser Asp Arg Ala His Ala Asn Gly Ser Val Arg Arg Gly His
            2100                2105                2110        
Lys Asn Asp Ala Thr Glu Thr Ile Thr Met Arg Thr Gly Leu Gly Val
        2115                2120                2125            
Asn Leu Lys Glu Val Lys Ile Phe Asn Arg Val Arg Glu Lys Gly Thr
    2130                2135                2140                
Asn Val Cys Ala Arg Asp Asn Gly Gly Cys Lys Gln Leu Cys Leu Tyr
2145                2150                2155                2160
Arg Gly Asn Ser Arg Arg Thr Cys Ala Cys Ala His Gly Tyr Leu Ala
                2165                2170                2175    
Glu Asp Gly Val Thr Cys Leu Arg His Glu Gly Tyr Leu Leu Tyr Ser
            2180                2185                2190        
Gly Arg Thr Ile Leu Lys Ser Ile His Leu Ser Asp Glu Thr Asn Leu
        2195                2200                2205            
Asn Ser Pro Ile Arg Pro Tyr Glu Asn Pro Arg Tyr Phe Lys Asn Val
    2210                2215                2220                
Ile Ala Leu Ala Phe Asp Tyr Asn Gln Arg Arg Lys Gly Thr Asn Arg
2225                2230                2235                2240
Ile Phe Tyr Ser Asp Ala His Phe Gly Asn Ile Gln Leu Ile Lys Asp
                2245                2250                2255    
Asn Trp Glu Asp Arg Gln Val Ile Val Glu Asn Val Gly Ser Val Glu
            2260                2265                2270        
Gly Leu Ala Tyr His Arg Ala Trp Asp Thr Leu Tyr Trp Thr Ser Ser
        2275                2280                2285            
Thr Thr Ser Ser Ile Thr Arg His Thr Val Asp Gln Thr Arg Pro Gly
    2290                2295                2300                
Ala Phe Asp Arg Glu Ala Val Ile Thr Met Ser Glu Asp Asp His Pro
2305                2310                2315                2320
His Val Leu Ala Leu Asp Glu Cys Gln Asn Leu Met Phe Trp Thr Asn
                2325                2330                2335    
Trp Asn Glu Gln His Pro Ser Ile Met Arg Ser Thr Leu Thr Gly Lys
            2340                2345                2350        
Asn Ala Gln Val Val Val Ser Thr Asp Ile Leu Thr Pro Asn Gly Leu
        2355                2360                2365            
Thr Ile Asp Tyr Arg Ala Glu Lys Leu Tyr Phe Ser Asp Gly Ser Leu
    2370                2375                2380                
Gly Lys Ile Glu Arg Cys Glu Tyr Asp Gly Ser Gln Arg His Val Ile
2385                2390                2395                2400
Val Lys Ser Gly Pro Gly Thr Phe Leu Ser Leu Ala Val Tyr Asp Asn
                2405                2410                2415    
Tyr Ile Phe Trp Ser Asp Trp Gly Arg Arg Ala Ile Leu Arg Ser Asn
            2420                2425                2430        
Lys Tyr Thr Gly Gly Asp Thr Lys Ile Leu Arg Ser Asp Ile Pro His
        2435                2440                2445            
Gln Pro Met Gly Ile Ile Ala Val Ala Asn Asp Thr Asn Ser Cys Glu
    2450                2455                2460                
Leu Ser Pro Cys Ala Leu Leu Asn Gly Gly Cys His Asp Leu Cys Leu
2465                2470                2475                2480
Leu Thr Pro Asn Gly Arg Val Asn Cys Ser Cys Arg Gly Asp Arg Ile
                2485                2490                2495    
Leu Leu Glu Asp Asn Arg Cys Val Thr Lys Asn Ser Ser Cys Asn Ala
            2500                2505                2510        
Tyr Ser Glu Phe Glu Cys Gly Asn Gly Glu Cys Ile Asp Tyr Gln Leu
        2515                2520                2525            
Thr Cys Asp Gly Ile Pro His Cys Lys Asp Lys Ser Asp Glu Lys Leu
    2530                2535                2540                
Leu Tyr Cys Glu Asn Arg Ser Cys Arg Arg Gly Phe Lys Pro Cys Tyr
2545                2550                2555                2560
Asn Arg Arg Cys Ile Pro His Gly Lys Leu Cys Asp Gly Glu Asn Asp
                2565                2570                2575    
Cys Gly Asp Asn Ser Asp Glu Leu Asp Cys Lys Val Ser Thr Cys Ala
            2580                2585                2590        
Thr Val Glu Phe Arg Cys Ala Asp Gly Thr Cys Ile Pro Arg Ser Ala
        2595                2600                2605            
Arg Cys Asn Gln Asn Ile Asp Cys Ala Asp Ala Ser Asp Glu Lys Asn
    2610                2615                2620                
Cys Asn Asn Thr Asp Cys Thr His Phe Tyr Lys Leu Gly Val Lys Thr
2625                2630                2635                2640
Thr Gly Phe Ile Arg Cys Asn Ser Thr Ser Leu Cys Val Leu Pro Thr
                2645                2650                2655    
Trp Ile Cys Asp Gly Ser Asn Asp Cys Gly Asp Tyr Ser Asp Glu Leu
            2660                2665                2670        
Lys Cys Pro Val Gln Asn Lys His Lys Cys Glu Glu Asn Tyr Phe Ser
        2675                2680                2685            
Cys Pro Ser Gly Arg Cys Ile Leu Asn Thr Trp Ile Cys Asp Gly Gln
    2690                2695                2700                
Lys Asp Cys Glu Asp Gly Arg Asp Glu Phe His Cys Asp Ser Ser Cys
2705                2710                2715                2720
Ser Trp Asn Gln Phe Ala Cys Ser Ala Gln Lys Cys Ile Ser Lys His
                2725                2730                2735    
Trp Ile Cys Asp Gly Glu Asp Asp Cys Gly Asp Gly Leu Asp Glu Ser
            2740                2745                2750        
Asp Ser Ile Cys Gly Ala Ile Thr Cys Ala Ala Asp Met Phe Ser Cys
        2755                2760                2765            
Gln Gly Ser Arg Ala Cys Val Pro Arg His Trp Leu Cys Asp Gly Glu
    2770                2775                2780                
Arg Asp Cys Pro Asp Gly Ser Asp Glu Leu Ser Thr Ala Gly Cys Ala
2785                2790                2795                2800
Pro Asn Asn Thr Cys Asp Glu Asn Ala Phe Met Cys His Asn Lys Val
                2805                2810                2815    
Cys Ile Pro Lys Gln Phe Val Cys Asp His Asp Asp Asp Cys Gly Asp
            2820                2825                2830        
Gly Ser Asp Glu Ser Pro Gln Cys Gly Tyr Arg Gln Cys Gly Thr Glu
        2835                2840                2845            
Glu Phe Ser Cys Ala Asp Gly Arg Cys Leu Leu Asn Thr Gln Trp Gln
    2850                2855                2860                
Cys Asp Gly Asp Phe Asp Cys Pro Asp His Ser Asp Glu Ala Pro Leu
2865                2870                2875                2880
Asn Pro Lys Cys Lys Ser Ala Glu Gln Ser Cys Asn Ser Ser Phe Phe
                2885                2890                2895    
Met Cys Lys Asn Gly Arg Cys Ile Pro Ser Gly Gly Leu Cys Asp Asn
            2900                2905                2910        
Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Arg Asn Cys His Ile Asn
        2915                2920                2925            
Glu Cys Leu Ser Lys Lys Val Ser Gly Cys Ser Gln Asp Cys Gln Asp
    2930                2935                2940                
Leu Pro Val Ser Tyr Lys Cys Lys Cys Trp Pro Gly Phe Gln Leu Lys
2945                2950                2955                2960
Asp Asp Gly Lys Thr Cys Val Asp Ile Asp Glu Cys Ser Ser Gly Phe
                2965                2970                2975    
Pro Cys Ser Gln Gln Cys Ile Asn Thr Tyr Gly Thr Tyr Lys Cys Leu
            2980                2985                2990        
Cys Thr Asp Gly Tyr Glu Ile Gln Pro Asp Asn Pro Asn Gly Cys Lys
        2995                3000                3005            
Ser Leu Ser Asp Glu Glu Pro Phe Leu Ile Leu Ala Asp His His Glu
    3010                3015                3020                
Ile Arg Lys Ile Ser Thr Asp Gly Ser Asn Tyr Thr Leu Leu Lys Gln
3025                3030                3035                3040
Gly Leu Asn Asn Val Ile Ala Ile Asp Phe Asp Tyr Arg Glu Glu Phe
                3045                3050                3055    
Ile Tyr Trp Ile Asp Ser Ser Arg Pro Asn Gly Ser Arg Ile Asn Arg
            3060                3065                3070        
Met Cys Leu Asn Gly Ser Asp Ile Lys Val Val His Asn Thr Ala Val
        3075                3080                3085            
Pro Asn Ala Leu Ala Val Asp Trp Ile Gly Lys Asn Leu Tyr Trp Ser
    3090                3095                3100                
Asp Thr Glu Lys Arg Ile Ile Glu Val Ser Lys Leu Asn Gly Leu Tyr
3105                3110                3115                3120
Pro Thr Ile Leu Val Ser Lys Arg Leu Lys Phe Pro Arg Asp Leu Ser
                3125                3130                3135    
Leu Asp Pro Gln Ala Gly Tyr Leu Tyr Trp Ile Asp Cys Cys Glu Tyr
            3140                3145                3150        
Pro His Ile Gly Arg Val Gly Met Asp Gly Thr Asn Gln Ser Val Val
        3155                3160                3165            
Ile Glu Thr Lys Ile Ser Arg Pro Met Ala Leu Thr Ile Asp Tyr Val
    3170                3175                3180                
Asn Arg Arg Leu Tyr Trp Ala Asp Glu Asn His Ile Glu Phe Ser Asn
3185                3190                3195                3200
Met Asp Gly Ser His Arg His Lys Val Pro Asn Gln Asp Ile Pro Gly
                3205                3210                3215    
Val Ile Ala Leu Thr Leu Phe Glu Asp Tyr Ile Tyr Trp Thr Asp Gly
            3220                3225                3230        
Lys Thr Lys Ser Leu Ser Arg Ala His Lys Thr Ser Gly Ala Asp Arg
        3235                3240                3245            
Leu Ser Leu Ile Tyr Ser Trp His Ala Ile Thr Asp Ile Gln Val Tyr
    3250                3255                3260                
His Ser Tyr Arg Gln Pro Asp Val Ser Lys His Leu Cys Met Ile Asn
3265                3270                3275                3280
Asn Gly Gly Cys Ser His Leu Cys Leu Leu Ala Pro Gly Lys Thr His
                3285                3290                3295    
Thr Cys Ala Cys Pro Thr Asn Phe Tyr Leu Ala Ala Asp Asn Arg Thr
            3300                3305                3310        
Cys Leu Ser Asn Cys Thr Ala Ser Gln Phe Arg Cys Lys Thr Asp Lys
        3315                3320                3325            
Cys Ile Pro Phe Trp Trp Lys Cys Asp Thr Val Asp Asp Cys Gly Asp
    3330                3335                3340                
Gly Ser Asp Glu Pro Asp Asp Cys Pro Glu Phe Arg Cys Gln Pro Gly
3345                3350                3355                3360
Arg Phe Gln Cys Gly Thr Gly Leu Cys Ala Leu Pro Ala Phe Ile Cys
                3365                3370                3375    
Asp Gly Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Leu Asn Cys Asp
            3380                3385                3390        
Thr His Val Cys Leu Ser Gly Gln Phe Lys Cys Thr Lys Asn Gln Lys
        3395                3400                3405            
Cys Ile Pro Val Asn Leu Arg Cys Asn Gly Gln Asp Asp Cys Gly Asp
    3410                3415                3420                
Glu Glu Asp Glu Arg Asp Cys Pro Glu Asn Ser Cys Ser Pro Asp Tyr
3425                3430                3435                3440
Phe Gln Cys Lys Thr Thr Lys His Cys Ile Ser Lys Leu Trp Val Cys
                3445                3450                3455    
Asp Glu Asp Pro Asp Cys Ala Asp Ala Ser Asp Glu Ala Asn Cys Asp
            3460                3465                3470        
Lys Lys Thr Cys Gly Pro His Glu Phe Gln Cys Lys Asn Asn Asn Cys
        3475                3480                3485            
Ile Pro Asp His Trp Arg Cys Asp Ser Gln Asn Asp Cys Ser Asp Asn
    3490                3495                3500                
Ser Asp Glu Glu Asn Cys Lys Pro Gln Thr Cys Thr Leu Lys Asp Phe
3505                3510                3515                3520
Leu Cys Ala Asn Gly Asp Cys Val Ser Ser Arg Phe Trp Cys Asp Gly
                3525                3530                3535    
Asp Phe Asp Cys Ala Asp Gly Ser Asp Glu Arg Asn Cys Glu Thr Ser
            3540                3545                3550        
Cys Ser Lys Asp Gln Phe Arg Cys Ser Asn Gly Gln Cys Ile Pro Ala
        3555                3560                3565            
Lys Trp Lys Cys Asp Gly His Glu Asp Cys Lys Tyr Gly Glu Asp Glu
    3570                3575                3580                
Lys Ser Cys Glu Pro Ala Ser Pro Thr Cys Ser Ser Arg Glu Tyr Ile
3585                3590                3595                3600
Cys Ala Ser Asp Gly Cys Ile Ser Ala Ser Leu Lys Cys Asn Gly Glu
                3605                3610                3615    
Tyr Asp Cys Ala Asp Gly Ser Asp Glu Met Asp Cys Val Thr Glu Cys
            3620                3625                3630        
Lys Glu Asp Gln Phe Arg Cys Lys Asn Lys Ala His Cys Ile Pro Ile
        3635                3640                3645            
Arg Trp Leu Cys Asp Gly Ile His Asp Cys Val Asp Gly Ser Asp Glu
    3650                3655                3660                
Glu Asn Cys Glu Arg Gly Gly Asn Ile Cys Arg Ala Asp Glu Phe Leu
3665                3670                3675                3680
Cys Asn Asn Ser Leu Cys Lys Leu His Phe Trp Val Cys Asp Gly Glu
                3685                3690                3695    
Asp Asp Cys Gly Asp Asn Ser Asp Glu Ala Pro Asp Met Cys Val Lys
            3700                3705                3710        
Phe Leu Cys Pro Ser Thr Arg Pro His Arg Cys Arg Asn Asn Arg Ile
        3715                3720                3725            
Cys Leu Gln Ser Glu Gln Met Cys Asn Gly Ile Asp Glu Cys Gly Asp
    3730                3735                3740                
Asn Ser Asp Glu Asp His Cys Gly Gly Lys Leu Thr Tyr Lys Ala Arg
3745                3750                3755                3760
Pro Cys Lys Lys Asp Glu Phe Ala Cys Ser Asn Lys Lys Cys Ile Pro
                3765                3770                3775    
Met Asp Leu Gln Cys Asp Arg Leu Asp Asp Cys Gly Asp Gly Ser Asp
            3780                3785                3790        
Glu Gln Gly Cys Arg Ile Ala Pro Thr Glu Tyr Thr Cys Glu Asp Asn
        3795                3800                3805            
Val Asn Pro Cys Gly Asp Asp Ala Tyr Cys Asn Gln Ile Lys Thr Ser
    3810                3815                3820                
Val Phe Cys Arg Cys Lys Pro Gly Phe Gln Arg Asn Met Lys Asn Arg
3825                3830                3835                3840
Gln Cys Glu Asp Leu Asn Glu Cys Leu Val Phe Gly Thr Cys Ser His
                3845                3850                3855    
Gln Cys Ile Asn Val Glu Gly Ser Tyr Lys Cys Val Cys Asp Gln Asn
            3860                3865                3870        
Phe Gln Glu Arg Asn Asn Thr Cys Ile Ala Glu Gly Ser Glu Asp Gln
        3875                3880                3885            
Val Leu Tyr Ile Ala Asn Asp Thr Asp Ile Leu Gly Phe Ile Tyr Pro
    3890                3895                3900                
Phe Asn Tyr Ser Gly Asp His Gln Gln Ile Ser His Ile Glu His Asn
3905                3910                3915                3920
Ser Arg Ile Thr Gly Met Asp Val Tyr Tyr Gln Arg Asp Met Ile Ile
                3925                3930                3935    
Trp Ser Thr Gln Phe Asn Pro Gly Gly Ile Phe Tyr Lys Arg Ile His
            3940                3945                3950        
Gly Arg Glu Lys Arg Gln Ala Asn Ser Gly Leu Ile Cys Pro Glu Phe
        3955                3960                3965            
Lys Arg Pro Arg Asp Ile Ala Val Asp Trp Val Ala Gly Asn Ile Tyr
    3970                3975                3980                
Trp Thr Asp His Ser Arg Met His Trp Phe Ser Tyr Tyr Thr Thr His
3985                3990                3995                4000
Trp Thr Ser Leu Arg Tyr Ser Ile Asn Val Gly Gln Leu Asn Gly Pro
                4005                4010                4015    
Asn Cys Thr Arg Leu Leu Thr Asn Met Ala Gly Glu Pro Tyr Ala Ile
            4020                4025                4030        
Ala Val Asn Pro Lys Arg Gly Met Met Tyr Trp Thr Val Val Gly Asp
        4035                4040                4045            
His Ser His Ile Glu Glu Ala Ala Met Asp Gly Thr Leu Arg Arg Ile
    4050                4055                4060                
Leu Val Gln Lys Asn Leu Gln Arg Pro Thr Gly Leu Ala Val Asp Tyr
4065                4070                4075                4080
Phe Ser Glu Arg Ile Tyr Trp Ala Asp Phe Glu Leu Ser Ile Ile Gly
                4085                4090                4095    
Ser Val Leu Tyr Asp Gly Ser Asn Ser Val Val Ser Val Ser Ser Lys
            4100                4105                4110        
Gln Gly Leu Leu His Pro His Arg Ile Asp Ile Phe Glu Asp Tyr Ile
        4115                4120                4125            
Tyr Gly Ala Gly Pro Lys Asn Gly Val Phe Arg Val Gln Lys Phe Gly
    4130                4135                4140                
His Gly Ser Val Glu Tyr Leu Ala Leu Asn Ile Asp Lys Thr Lys Gly
4145                4150                4155                4160
Val Leu Ile Ser His Arg Tyr Lys Gln Leu Asp Leu Pro Asn Pro Cys
                4165                4170                4175    
Leu Asp Leu Ala Cys Glu Phe Leu Cys Leu Leu Asn Pro Ser Gly Ala
            4180                4185                4190        
Thr Cys Val Cys Pro Glu Gly Lys Tyr Leu Ile Asn Gly Thr Cys Asn
        4195                4200                4205            
Asp Asp Ser Leu Leu Asp Asp Ser Cys Lys Leu Thr Cys Glu Asn Gly
    4210                4215                4220                
Gly Arg Cys Ile Leu Asn Glu Lys Gly Asp Leu Arg Cys His Cys Trp
4225                4230                4235                4240
Pro Ser Tyr Ser Gly Glu Arg Cys Glu Val Asn His Cys Ser Asn Tyr
                4245                4250                4255    
Cys Gln Asn Gly Gly Thr Cys Val Pro Ser Val Leu Gly Arg Pro Thr
            4260                4265                4270        
Cys Ser Cys Ala Leu Gly Phe Thr Gly Pro Asn Cys Gly Lys Thr Val
        4275                4280                4285            
Cys Glu Asp Phe Cys Gln Asn Gly Gly Thr Cys Ile Val Thr Ala Gly
    4290                4295                4300                
Asn Gln Pro Tyr Cys His Cys Gln Pro Glu Tyr Thr Gly Asp Arg Cys
4305                4310                4315                4320
Gln Tyr Tyr Val Cys His His Tyr Cys Val Asn Ser Glu Ser Cys Thr
                4325                4330                4335    
Ile Gly Asp Asp Gly Ser Xaa Glu Cys Val Cys Pro Thr Arg Tyr Glu
            4340                4345                4350        
Gly Pro Lys Cys Glu Val Asp Lys Cys Val Arg Cys His Gly Gly His
        4355                4360                4365            
Cys Ile Ile Asn Lys Asp Ser Glu Asp Ile Phe Cys Asn Cys Thr Asn
    4370                4375                4380                
Gly Lys Ile Ala Ser Ser Cys Gln Leu Cys Asp Gly Tyr Cys Tyr Asn
4385                4390                4395                4400
Gly Gly Thr Cys Gln Leu Asp Pro Glu Thr Asn Val Pro Val Cys Leu
                4405                4410                4415    
Cys Ser Thr Asn Trp Ser Gly Thr Gln Cys Glu Arg Pro Ala Pro Lys
            4420                4425                4430        
Ser Ser Lys Ser Asp His Ile Ser Thr Arg Ser Ile Ala Ile Ile Val
        4435                4440                4445            
Pro Leu Val Leu Leu Val Thr Leu Ile Thr Thr Leu Val Ile Gly Leu
    4450                4455                4460                
Val Leu Cys Lys Arg Lys Arg Arg Thr Lys Thr Ile Arg Arg Gln Pro
4465                4470                4475                4480
Ile Ile Asn Gly Gly Ile Asn Val Glu Ile Gly Asn Pro Ser Tyr Asn
                4485                4490                4495    
Met Tyr Glu Val Asp His Asp His Asn Asp Gly Gly Leu Leu Asp Pro
            4500                4505                4510        
Gly Phe Met Ile Asp Pro Thr Lys Ala Arg Tyr Ile Gly Gly Gly Pro
        4515                4520                4525            
Ser Ala Phe Lys Leu Pro His Thr Ala Pro Pro Ile Tyr Leu Asn Ser
    4530                4535                4540                
Asp Leu Lys Gly Pro Leu Thr Ala Gly Pro Thr Asn Tyr Ser Asn Pro
4545                4550                4555                4560
Val Tyr Ala Lys Leu Tyr Met Asp Gly Gln Asn Cys Arg Asn Ser Leu
                4565                4570                4575    
Gly Ser Val Asp Glu Arg Lys Glu Leu Leu Pro Lys Lys Ile Glu Ile
            4580                4585                4590        
Gly Ile Arg Glu Thr Val Ala
        4595                


<210> 8736
<211> 582
<212> PRT
<213> Homo sapiens

<400> 8736
Met Ser Lys Glu Glu Arg Pro Gly Arg Glu Glu Ile Leu Glu Cys Gln
 1               5                  10                  15      
Val Met Trp Glu Pro Asp Ser Lys Lys Asn Thr Gln Met Asp Arg Phe
            20                  25                  30          
Arg Ala Ala Val Gly Ala Ala Cys Gly Leu Ala Leu Glu Ser Tyr Asp
        35                  40                  45              
Asp Leu Tyr His Trp Ser Val Glu Ser Tyr Ser Asp Phe Trp Ala Glu
    50                  55                  60                  
Phe Trp Lys Phe Ser Glu Ile Val Phe Ser Arg Val Tyr Asp Glu Val
65                  70                  75                  80  
Val Asp Thr Ser Lys Gly Ile Ala Asp Val Pro Glu Trp Phe Lys Gly
                85                  90                  95      
Ser Arg Leu Asn Tyr Ala Glu Asn Leu Leu Arg His Lys Glu Asn Asp
            100                 105                 110         
Arg Val Ala Leu Tyr Ile Ala Arg Glu Gly Lys Glu Glu Ile Val Glu
        115                 120                 125             
Val Thr Phe Glu Glu Leu Arg Gln Glu Val Ala Leu Phe Ala Ala Ala
    130                 135                 140                 
Met Arg Lys Met Gly Val Lys Lys Gly Asp Arg Val Val Gly Tyr Leu
145                 150                 155                 160 
Pro Asn Ser Glu His Ala Val Glu Ala Met Leu Ala Ala Ala Ser Ile
                165                 170                 175     
Gly Ala Ile Trp Ser Ser Thr Ser Pro Asp Phe Gly Val Asn Gly Val
            180                 185                 190         
Leu Asp Arg Phe Ser Gln Ile Gln Pro Lys Leu Ile Phe Ser Val Glu
        195                 200                 205             
Ala Val Val Tyr Asn Gly Lys Glu His Asn His Met Glu Lys Leu Gln
    210                 215                 220                 
Gln Val Val Lys Gly Leu Pro Asp Leu Lys Lys Val Val Val Ile Pro
225                 230                 235                 240 
Tyr Val Ser Ser Arg Glu Asn Ile Asp Leu Ser Lys Ile Pro Asn Ser
                245                 250                 255     
Val Phe Leu Asp Asp Phe Leu Ala Thr Gly Thr Ser Glu Gln Ala Pro
            260                 265                 270         
Gln Leu Glu Phe Glu Gln Leu Pro Phe Ser His Pro Leu Phe Ile Met
        275                 280                 285             
Phe Ser Ser Gly Thr Thr Gly Ala Pro Lys Cys Met Val His Ser Ala
    290                 295                 300                 
Gly Gly Thr Leu Ile Gln His Leu Lys Glu His Leu Leu His Gly Asn
305                 310                 315                 320 
Met Thr Ser Ser Asp Ile Leu Leu Cys Tyr Thr Thr Val Gly Trp Met
                325                 330                 335     
Met Trp Asn Trp Met Val Ser Leu Leu Ala Thr Gly Ala Ala Met Val
            340                 345                 350         
Leu Tyr Asp Gly Ser Pro Leu Val Pro Thr Pro Asn Val Leu Trp Asp
        355                 360                 365             
Leu Val Asp Arg Ile Gly Ile Thr Val Leu Val Thr Gly Ala Lys Trp
    370                 375                 380                 
Leu Ser Val Leu Glu Glu Lys Ala Met Lys Pro Val Glu Thr His Ser
385                 390                 395                 400 
Leu Gln Met Leu His Thr Ile Leu Ser Thr Gly Ser Pro Leu Lys Ala
                405                 410                 415     
Gln Ser Tyr Glu Tyr Val Tyr Arg Cys Ile Lys Ser Ser Ile Leu Leu
            420                 425                 430         
Gly Ser Ile Ser Gly Gly Thr Asp Ile Ile Ser Cys Phe Met Gly His
        435                 440                 445             
Asn Phe Ser Leu Pro Val Tyr Lys Gly Glu Ile Gln Ala Arg Asn Leu
    450                 455                 460                 
Gly Met Ala Val Glu Ala Trp Asn Glu Glu Gly Lys Ala Val Trp Gly
465                 470                 475                 480 
Glu Ser Gly Glu Leu Val Cys Thr Lys Pro Ile Pro Cys Gln Pro Thr
                485                 490                 495     
His Phe Trp Asn Asp Glu Asn Gly Asn Lys Tyr Arg Lys Ala Tyr Phe
            500                 505                 510         
Ser Lys Phe Pro Gly Ile Gly Leu Met Ala Thr Thr Ala Glu Ser Thr
        515                 520                 525             
Pro Arg Pro Gly Ala Ser Ser Cys Leu Ala Gly Val Thr Ala Pro Ser
    530                 535                 540                 
Thr Pro Thr Gly Cys Gly Ser Ala Ala Arg Lys Ser Ile Thr Leu Trp
545                 550                 555                 560 
Asn Pro Ser Arg Arg Trp Arg Thr Ala Cys Val Ser Pro Ser Ile Thr
                565                 570                 575     
Ser Thr Gly Arg Arg Gly
            580         


<210> 8737
<211> 740
<212> PRT
<213> Homo sapiens

<400> 8737
Pro Ala Gly Arg Gly Leu Gly Gln Ala Ala Arg Arg Arg Arg Arg Arg
 1               5                  10                  15      
Pro Phe Ser Pro Leu Phe Pro Ala Ala Ala Val Ala Asp Pro Ala Arg
            20                  25                  30          
Gln Ala Leu Leu Thr Val Ala Ser Ser Gly Pro Arg Ser Pro Ala Leu
        35                  40                  45              
Ala Ser Ala Pro Ala Pro Gly Pro Gln Pro Ser Ser Gln Pro Arg Pro
    50                  55                  60                  
Pro Ala Ala Ala Met Ser Lys Glu Glu Arg Pro Gly Arg Glu Glu Ile
65                  70                  75                  80  
Leu Glu Cys Gln Val Met Trp Glu Pro Asp Ser Lys Lys Asn Thr Gln
                85                  90                  95      
Met Asp Arg Phe Arg Ala Ala Val Gly Ala Ala Cys Gly Leu Ala Leu
            100                 105                 110         
Glu Ser Tyr Asp Asp Leu Tyr His Trp Ser Val Glu Ser Tyr Ser Asp
        115                 120                 125             
Phe Trp Ala Glu Phe Trp Lys Phe Ser Gly Ile Val Phe Ser Arg Val
    130                 135                 140                 
Tyr Asp Glu Val Val Asp Thr Ser Lys Gly Ile Ala Asp Val Pro Glu
145                 150                 155                 160 
Trp Phe Lys Gly Ser Arg Leu Asn Tyr Ala Glu Asn Leu Leu Arg His
                165                 170                 175     
Lys Glu Asn Asp Arg Val Ala Leu Tyr Val Ala Arg Glu Gly Lys Glu
            180                 185                 190         
Glu Ile Val Lys Val Thr Phe Glu Glu Leu Arg Gln Glu Val Ala Leu
        195                 200                 205             
Phe Ala Ala Ala Met Arg Lys Met Gly Val Lys Lys Gly Asp Arg Val
    210                 215                 220                 
Val Gly Tyr Leu Pro Asn Ser Glu His Ala Val Glu Ala Met Leu Ala
225                 230                 235                 240 
Ala Ala Ser Ile Gly Ala Ile Trp Ser Ser Thr Ser Pro Asp Phe Gly
                245                 250                 255     
Val Asn Gly Val Leu Asp Arg Phe Ser Gln Ile Gln Pro Lys Leu Ile
            260                 265                 270         
Phe Ser Val Glu Ala Val Val Tyr Asn Gly Lys Glu His Asn His Met
        275                 280                 285             
Glu Lys Leu Gln Gln Val Val Lys Gly Leu Pro Asp Leu Lys Lys Val
    290                 295                 300                 
Val Val Ile Pro Tyr Val Ser Ser Arg Glu Asn Ile Asp Leu Ser Lys
305                 310                 315                 320 
Ile Pro Asn Ser Val Phe Leu Asp Asp Phe Leu Ala Thr Gly Thr Ser
                325                 330                 335     
Glu Gln Ala Pro Gln Leu Glu Phe Glu Gln Leu Pro Phe Ser His Pro
            340                 345                 350         
Leu Phe Ile Met Phe Ser Ser Gly Thr Thr Gly Ala Pro Lys Cys Met
        355                 360                 365             
Val His Ser Ala Gly Gly Thr Leu Ile Gln His Leu Lys Glu His Leu
    370                 375                 380                 
Leu His Gly Asn Met Thr Ser Ser Asp Ile Leu Leu Cys Tyr Thr Thr
385                 390                 395                 400 
Val Gly Trp Met Met Trp Asn Trp Met Val Ser Leu Leu Ala Thr Gly
                405                 410                 415     
Ala Ala Met Val Leu Tyr Asp Gly Ser Pro Leu Val Pro Thr Pro Asn
            420                 425                 430         
Val Leu Trp Asp Leu Val Asp Arg Ile Gly Ile Thr Val Leu Val Thr
        435                 440                 445             
Gly Ala Lys Trp Leu Ser Val Leu Glu Glu Lys Ala Met Lys Pro Val
    450                 455                 460                 
Glu Thr His Ser Leu Gln Met Leu His Thr Ile Leu Ser Thr Gly Ser
465                 470                 475                 480 
Pro Leu Lys Ala Gln Ser Tyr Glu Tyr Val Tyr Arg Cys Ile Lys Ser
                485                 490                 495     
Ser Ile Leu Leu Gly Ser Ile Ser Gly Gly Thr Asp Ile Ile Ser Cys
            500                 505                 510         
Phe Met Gly His Asn Phe Ser Leu Pro Val Tyr Lys Gly Glu Ile Gln
        515                 520                 525             
Ala Arg Asn Leu Gly Met Ala Val Glu Ala Trp Asn Glu Glu Gly Lys
    530                 535                 540                 
Ala Val Trp Gly Glu Ser Gly Glu Leu Val Cys Thr Lys Pro Ile Pro
545                 550                 555                 560 
Cys Gln Pro Thr His Phe Trp Asn Asp Glu Asn Gly Asn Lys Tyr Arg
                565                 570                 575     
Lys Ala Tyr Phe Ser Lys Phe Pro Gly Ile Trp Ala His Gly Asp Tyr
            580                 585                 590         
Cys Arg Ile Asn Pro Lys Thr Gly Gly Ile Val Met Leu Gly Arg Ser
        595                 600                 605             
Asp Gly Thr Leu Asn Pro Asn Gly Val Arg Phe Gly Ser Ser Glu Ile
    610                 615                 620                 
Tyr Asn Ile Val Glu Ser Phe Glu Glu Val Glu Asp Ser Leu Cys Val
625                 630                 635                 640 
Pro Gln Tyr Asn Lys Tyr Arg Glu Glu Arg Val Ile Leu Phe Leu Lys
                645                 650                 655     
Met Ala Ser Gly His Ala Phe Gln Pro Asp Leu Val Lys Arg Ile Arg
            660                 665                 670         
Asp Ala Ile Arg Met Gly Leu Ser Ala Arg His Val Pro Ser Leu Ile
        675                 680                 685             
Leu Glu Thr Lys Gly Ile Pro Tyr Thr Leu Asn Gly Lys Lys Val Glu
    690                 695                 700                 
Val Ala Val Lys Gln Ile Ile Ala Gly Lys Ala Val Glu Gln Gly Gly
705                 710                 715                 720 
Ala Phe Ser Asn Pro Glu Thr Leu Asp Leu Tyr Arg Asp Ile Pro Glu
                725                 730                 735     
Leu Gln Gly Phe
            740 


<210> 8738
<211> 1134
<212> PRT
<213> Homo sapiens

<400> 8738
Met Lys Tyr Ser Cys Cys Ala Leu Val Leu Ala Val Leu Gly Thr Glu
 1               5                  10                  15      
Leu Leu Gly Ser Leu Cys Ser Thr Val Arg Ser Pro Arg Phe Arg Gly
            20                  25                  30          
Arg Ile Gln Gln Glu Arg Lys Asn Ile Arg Pro Asn Ile Ile Leu Val
        35                  40                  45              
Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Leu Gln Val Met Asn
    50                  55                  60                  
Lys Thr Arg Lys Ile Met Glu His Gly Gly Ala Thr Phe Ile Asn Ala
65                  70                  75                  80  
Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Met Leu Thr
                85                  90                  95      
Gly Lys Tyr Val His Asn His Asn Val Tyr Thr Asn Asn Glu Asn Cys
            100                 105                 110         
Ser Ser Pro Ser Trp Gln Ala Met His Glu Pro Arg Thr Phe Ala Val
        115                 120                 125             
Tyr Leu Asn Asn Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr Leu
    130                 135                 140                 
Asn Glu Tyr Asn Gly Ser Tyr Ile Pro Pro Gly Trp Arg Glu Trp Leu
145                 150                 155                 160 
Gly Leu Ile Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Val Cys Arg Asn
                165                 170                 175     
Gly Ile Lys Glu Lys His Gly Phe Asp Tyr Ala Lys Asp Tyr Phe Thr
            180                 185                 190         
Asp Leu Ile Thr Asn Glu Ser Ile Asn Tyr Phe Lys Met Ser Lys Arg
        195                 200                 205             
Met Tyr Pro His Arg Pro Val Met Met Val Ile Ser His Ala Ala Pro
    210                 215                 220                 
His Gly Pro Glu Asp Ser Ala Pro Gln Phe Ser Lys Leu Tyr Pro Asn
225                 230                 235                 240 
Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Met Asp
                245                 250                 255     
Lys His Trp Ile Met Gln Tyr Thr Gly Pro Met Leu Pro Ile His Met
            260                 265                 270         
Glu Phe Thr Asn Ile Leu Gln Arg Lys Arg Leu Gln Thr Leu Met Ser
        275                 280                 285             
Val Asp Asp Ser Val Glu Arg Leu Tyr Asn Met Leu Val Glu Thr Gly
    290                 295                 300                 
Glu Leu Glu Asn Thr Tyr Ile Ile Tyr Thr Ala Asp His Gly Tyr His
305                 310                 315                 320 
Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Asp Phe
                325                 330                 335     
Asp Ile Arg Val Pro Phe Phe Ile Arg Gly Pro Ser Val Glu Pro Gly
            340                 345                 350         
Ser Ile Val Pro Gln Ile Val Leu Asn Ile Asp Leu Ala Pro Thr Ile
        355                 360                 365             
Leu Asp Ile Ala Gly Leu Asp Thr Pro Pro Asp Val Asp Gly Lys Ser
    370                 375                 380                 
Val Leu Lys Leu Leu Asp Pro Glu Lys Pro Gly Asn Arg Phe Arg Thr
385                 390                 395                 400 
Asn Lys Lys Ala Lys Ile Trp Arg Asp Thr Phe Leu Val Glu Arg Gly
                405                 410                 415     
Lys Phe Leu Arg Lys Lys Glu Glu Ser Ser Lys Asn Ile Gln Gln Ser
            420                 425                 430         
Asn His Leu Pro Lys Tyr Glu Arg Val Lys Glu Leu Cys Gln Gln Ala
        435                 440                 445             
Arg Tyr Gln Thr Ala Cys Glu Gln Pro Gly Gln Lys Trp Gln Cys Ile
    450                 455                 460                 
Glu Asp Thr Ser Gly Lys Leu Arg Ile His Lys Cys Lys Gly Pro Ser
465                 470                 475                 480 
Asp Leu Leu Thr Val Arg Gln Ser Thr Arg Asn Leu Tyr Ala Arg Gly
                485                 490                 495     
Phe His Asp Lys Asp Lys Glu Cys Ser Cys Arg Glu Ser Gly Tyr Arg
            500                 505                 510         
Ala Ser Arg Ser Gln Arg Lys Ser Gln Arg Gln Phe Leu Arg Asn Gln
        515                 520                 525             
Gly Thr Pro Lys Tyr Lys Pro Arg Phe Val His Thr Arg Gln Thr Arg
    530                 535                 540                 
Ser Leu Ser Val Glu Phe Glu Gly Glu Ile Tyr Asp Ile Asn Leu Glu
545                 550                 555                 560 
Glu Glu Glu Glu Leu Gln Val Leu Gln Pro Arg Asn Ile Ala Lys Arg
                565                 570                 575     
His Asp Glu Gly His Lys Gly Pro Arg Asp Leu Gln Ala Ser Ser Gly
            580                 585                 590         
Gly Asn Arg Gly Arg Met Leu Ala Asp Ser Ser Asn Ala Val Gly Pro
        595                 600                 605             
Pro Thr Thr Val Arg Val Thr His Lys Cys Phe Ile Leu Pro Asn Asp
    610                 615                 620                 
Ser Ile His Cys Glu Arg Glu Leu Tyr Gln Ser Ala Arg Ala Trp Lys
625                 630                 635                 640 
Asp His Lys Ala Tyr Ile Asp Lys Glu Ile Glu Ala Leu Gln Asp Lys
                645                 650                 655     
Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Arg Arg Lys Pro
            660                 665                 670         
Glu Glu Cys Ser Cys Ser Lys Gln Ser Tyr Tyr Asn Lys Glu Lys Gly
        675                 680                 685             
Val Lys Lys Gln Glu Lys Leu Lys Ser His Leu His Pro Phe Lys Glu
    690                 695                 700                 
Ala Ala Gln Glu Val Asp Ser Lys Leu Gln Leu Phe Lys Glu Asn Asn
705                 710                 715                 720 
Arg Arg Arg Lys Lys Glu Arg Lys Glu Lys Arg Arg Gln Arg Lys Gly
                725                 730                 735     
Glu Glu Cys Ser Leu Pro Gly Leu Thr Cys Phe Thr His Asp Asn Asn
            740                 745                 750         
His Trp Gln Thr Ala Pro Phe Trp Asn Leu Gly Ser Phe Cys Ala Cys
        755                 760                 765             
Thr Ser Ser Asn Asn Asn Thr Tyr Trp Cys Leu Arg Thr Val Asn Glu
    770                 775                 780                 
Thr His Asn Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr
785                 790                 795                 800 
Phe Asp Met Asn Thr Asp Pro Tyr Gln Leu Thr Asn Thr Val His Thr
                805                 810                 815     
Val Glu Arg Gly Ile Leu Asn Gln Leu His Val Gln Leu Met Glu Leu
            820                 825                 830         
Arg Ser Cys Gln Gly Tyr Lys Gln Cys Asn Pro Arg Pro Lys Asn Leu
        835                 840                 845             
Asp Val Glu Glu Ile Lys Met Glu Glu Ala Met Thr Tyr Thr Glu Asp
    850                 855                 860                 
Ser Tyr Gly Met Asp Gly Lys Val Asn Gln Pro Arg Leu Thr Ala Asp
865                 870                 875                 880 
Ile Asn Trp Gln Gly Leu Glu Glu Leu His Ser Val Asn Glu Asn Ile
                885                 890                 895     
Tyr Glu Tyr Arg Gln Asn Tyr Arg Leu Ser Leu Val Asp Trp Thr Asn
            900                 905                 910         
Tyr Leu Lys Asp Leu Asp Arg Val Phe Ala Leu Leu Lys Ser His Tyr
        915                 920                 925             
Glu Gln Asn Lys Thr Asn Lys Thr Gln Thr Ala Gln Ser Asp Gly Phe
    930                 935                 940                 
Leu Val Val Ser Ala Glu His Ala Val Ser Met Glu Met Ala Ser Ala
945                 950                 955                 960 
Asp Ser Asp Glu Asp Pro Arg His Lys Val Gly Lys Thr Pro His Leu
                965                 970                 975     
Thr Leu Pro Ala Asp Leu Gln Thr Leu His Leu Asn Arg Pro Thr Leu
            980                 985                 990         
Ser Pro Glu Ser Lys Leu Glu Trp Asn Asn Asp Ile Pro Glu Val Asn
        995                 1000                1005            
His Leu Asn Ser Glu His Trp Arg Lys Thr Glu Lys Trp Thr Gly His
    1010                1015                1020                
Glu Glu Thr Asn His Leu Glu Thr Asp Phe Ser Gly Asp Gly Met Thr
1025                1030                1035                1040
Glu Leu Glu Leu Gly Pro Ser Pro Arg Leu Gln Pro Ile Arg Arg His
                1045                1050                1055    
Pro Lys Glu Leu Pro Gln Tyr Gly Gly Pro Gly Lys Asp Ile Phe Glu
            1060                1065                1070        
Asp Gln Leu Tyr Leu Pro Val His Ser Asp Gly Ile Ser Val His Gln
        1075                1080                1085            
Met Phe Thr Met Ala Thr Ala Glu His Arg Ser Asn Ser Ser Ile Ala
    1090                1095                1100                
Gly Lys Met Leu Thr Lys Val Glu Lys Asn His Glu Lys Glu Lys Ser
1105                1110                1115                1120
Gln His Leu Glu Gly Ser Ala Ser Ser Ser Leu Ser Ser Asp
                1125                1130                


<210> 8739
<211> 281
<212> PRT
<213> Homo sapiens

<400> 8739
Met Leu Leu Ile Ser Leu Leu Leu Ala Ala Gly Leu Met His Ser Asp
 1               5                  10                  15      
Ala Gly Thr Ser Cys Pro Val Leu Cys Thr Cys Arg Asn Gln Val Val
            20                  25                  30          
Asp Cys Ser Ser Gln Arg Leu Phe Ser Val Pro Pro Asp Leu Pro Met
        35                  40                  45              
Asp Thr Arg Asn Leu Ser Leu Ala His Asn Arg Ile Thr Ala Val Pro
    50                  55                  60                  
Pro Gly Tyr Leu Thr Cys Tyr Met Glu Leu Gln Val Leu Asp Leu His
65                  70                  75                  80  
Asn Asn Ser Leu Met Glu Leu Pro Arg Gly Leu Phe Leu His Ala Lys
                85                  90                  95      
Arg Leu Ala His Leu Asp Leu Ser Tyr Asn Asn Phe Ser His Val Pro
            100                 105                 110         
Ala Asp Met Phe Gln Glu Ala His Gly Leu Val His Ile Asp Leu Ser
        115                 120                 125             
His Asn Pro Trp Leu Arg Arg Val His Pro Gln Ala Phe Gln Gly Leu
    130                 135                 140                 
Met Gln Leu Arg Asp Leu Asp Leu Ser Tyr Gly Gly Leu Ala Phe Leu
145                 150                 155                 160 
Ser Leu Glu Ala Leu Glu Gly Leu Pro Gly Leu Val Thr Leu Gln Ile
                165                 170                 175     
Gly Gly Asn Pro Trp Val Cys Gly Cys Thr Met Glu Pro Leu Leu Lys
            180                 185                 190         
Trp Leu Arg Asn Arg Ile Gln Arg Cys Thr Ala Asp Ser Gln Leu Ala
        195                 200                 205             
Glu Cys Arg Gly Pro Pro Glu Val Glu Gly Ala Pro Leu Phe Ser Leu
    210                 215                 220                 
Thr Glu Glu Ser Phe Lys Ala Cys His Leu Thr Leu Thr Leu Asp Asp
225                 230                 235                 240 
Tyr Leu Phe Ile Ala Phe Val Gly Phe Val Val Ser Ile Ala Ser Val
                245                 250                 255     
Ala Thr Asn Phe Leu Leu Gly Ile Thr Ala Asn Cys Cys His Arg Trp
            260                 265                 270         
Ser Lys Ala Ser Glu Glu Glu Glu Ile
        275                 280     


<210> 8740
<211> 244
<212> PRT
<213> Homo sapiens

<400> 8740
Met Gly Pro Pro Ser Ala Ala Pro Arg Gly Gly His Arg Pro Trp Gln
 1               5                  10                  15      
Gly Leu Leu Ile Thr Ala Ser Leu Leu Thr Phe Trp Asp Pro Pro Thr
            20                  25                  30          
Thr Val Gln Phe Thr Ile Glu Ala Leu Pro Ser Ser Ala Ala Glu Gly
        35                  40                  45              
Lys Asp Val Leu Leu Leu Ala Cys Asn Ile Ser Glu Thr Ile Gln Ala
    50                  55                  60                  
Tyr Tyr Trp His Lys Gly Lys Thr Ala Glu Gly Ser Pro Leu Ile Ala
65                  70                  75                  80  
Gly Tyr Ile Thr Asp Ile Gln Ala Asn Ile Pro Gly Ala Ala Tyr Ser
                85                  90                  95      
Gly Arg Glu Gln Val Tyr Pro Asn Gly Ser Leu Leu Phe Gln Asn Ile
            100                 105                 110         
Thr Leu Glu Asp Ala Gly Ser Tyr Thr Leu Arg Thr Ile Asn Ala Ser
        115                 120                 125             
Tyr Asp Ser Asp Gln Ala Thr Gly Gln Leu His Val His Gln Asn Asn
    130                 135                 140                 
Val Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val
145                 150                 155                 160 
Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu
                165                 170                 175     
Ser Arg Thr Gly Arg Ala Ser Ile Gln Arg Asp Leu Arg Glu Gln Pro
            180                 185                 190         
Pro Pro Ala Ser Thr Pro Gly His Gly Pro Ser His Arg Ser Thr Phe
        195                 200                 205             
Ser Ala Pro Leu Pro Ser Pro Arg Thr Ala Thr Pro Ile Tyr Val Glu
    210                 215                 220                 
Phe Leu Tyr Ser Asp Ala Asn Ile Tyr Cys Gln Ile Asp His Lys Ala
225                 230                 235                 240 
Asp Val Val Ser
                


<210> 8741
<211> 393
<212> PRT
<213> Homo sapiens

<400> 8741
Met Trp Trp Arg Val Leu Ser Leu Leu Ala Trp Phe Pro Leu Gln Glu
 1               5                  10                  15      
Ala Ser Leu Thr Asn His Thr Glu Thr Ile Thr Val Glu Glu Gly Gln
            20                  25                  30          
Thr Leu Thr Leu Lys Cys Val Thr Ser Leu Arg Lys Asn Ser Ser Leu
        35                  40                  45              
Gln Trp Leu Thr Pro Ser Gly Phe Thr Ile Phe Leu Asn Glu Tyr Pro
    50                  55                  60                  
Ala Leu Lys Asn Ser Lys Tyr Gln Leu Leu His His Ser Ala Asn Gln
65                  70                  75                  80  
Leu Ser Ile Thr Val Pro Asn Val Thr Leu Gln Asp Glu Gly Val Tyr
                85                  90                  95      
Lys Cys Leu His Tyr Ser Asp Ser Val Ser Thr Lys Glu Val Lys Val
            100                 105                 110         
Ile Val Leu Ala Thr Pro Phe Lys Pro Ile Leu Glu Ala Ser Val Ile
        115                 120                 125             
Arg Lys Gln Asn Gly Glu Glu His Val Val Leu Met Cys Ser Thr Met
    130                 135                 140                 
Arg Ser Lys Pro Pro Pro Gln Ile Thr Trp Leu Leu Gly Asn Ser Met
145                 150                 155                 160 
Glu Val Ser Gly Gly Thr Leu His Glu Phe Glu Thr Asp Gly Lys Lys
                165                 170                 175     
Cys Asn Thr Thr Ser Thr Leu Ile Ile His Thr Tyr Gly Lys Asn Ser
            180                 185                 190         
Thr Val Asp Cys Ile Ile Arg His Arg Gly Leu Gln Gly Arg Lys Leu
        195                 200                 205             
Val Ala Pro Phe Arg Phe Glu Asp Leu Val Thr Asp Glu Glu Thr Ala
    210                 215                 220                 
Ser Asp Ala Leu Glu Arg Asn Ser Leu Ser Ser Gln Asp Pro Gln Gln
225                 230                 235                 240 
Pro Thr Ser Thr Val Ser Val Thr Glu Asp Ser Ser Thr Ser Glu Ile
                245                 250                 255     
Asp Lys Glu Glu Lys Glu Gln Thr Thr Gln Asp Pro Asp Leu Thr Thr
            260                 265                 270         
Glu Ala Asn Pro Gln Tyr Leu Gly Leu Ala Arg Lys Lys Ser Gly Ile
        275                 280                 285             
Leu Leu Leu Thr Leu Val Ser Phe Leu Ile Phe Ile Leu Phe Ile Ile
    290                 295                 300                 
Val Gln Leu Phe Ile Met Lys Leu Arg Lys Ala His Val Ile Trp Lys
305                 310                 315                 320 
Arg Glu Asn Glu Val Ser Glu His Thr Leu Glu Ser Tyr Arg Ser Arg
                325                 330                 335     
Ser Asn Asn Glu Glu Thr Ser Ser Glu Glu Lys Asn Gly Gln Ser Ser
            340                 345                 350         
His Pro Met Arg Cys Met Asn Tyr Ile Thr Lys Leu Tyr Ser Glu Ala
        355                 360                 365             
Lys Thr Lys Arg Lys Glu Asn Val Gln His Ser Lys Leu Glu Glu Lys
    370                 375                 380                 
His Ile Gln Val Pro Glu Ser Ile Val
385                 390             


<210> 8742
<211> 930
<212> PRT
<213> Homo sapiens

<400> 8742
Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro
 1               5                  10                  15      
Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly
            20                  25                  30          
Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly
        35                  40                  45              
Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu
    50                  55                  60                  
Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu
65                  70                  75                  80  
Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg
                85                  90                  95      
Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly
            100                 105                 110         
Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser
        115                 120                 125             
His Cys Phe Tyr Arg Gly Thr Val Asp Ala Ser Pro Arg Ser Leu Ala
    130                 135                 140                 
Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His
145                 150                 155                 160 
Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu
                165                 170                 175     
Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val
            180                 185                 190         
Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser
        195                 200                 205             
Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala
    210                 215                 220                 
His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp
225                 230                 235                 240 
Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp
                245                 250                 255     
Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu
            260                 265                 270         
Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln
        275                 280                 285             
His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His
    290                 295                 300                 
Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val
305                 310                 315                 320 
Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr
                325                 330                 335     
Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly
            340                 345                 350         
Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu
        355                 360                 365             
Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val
    370                 375                 380                 
Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp
385                 390                 395                 400 
Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu
                405                 410                 415     
Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser
            420                 425                 430         
Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala
        435                 440                 445             
Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu
    450                 455                 460                 
Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile
465                 470                 475                 480 
Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln
                485                 490                 495     
Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp
            500                 505                 510         
Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val
        515                 520                 525             
Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys
    530                 535                 540                 
Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys
545                 550                 555                 560 
Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp
                565                 570                 575     
Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg
            580                 585                 590         
His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly
        595                 600                 605             
Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn
    610                 615                 620                 
Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln
625                 630                 635                 640 
Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr
                645                 650                 655     
Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys
            660                 665                 670         
Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr
        675                 680                 685             
Glu Cys Arg Pro Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val
    690                 695                 700                 
Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys
705                 710                 715                 720 
Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly
                725                 730                 735     
Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro
            740                 745                 750         
Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln
        755                 760                 765             
Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr
    770                 775                 780                 
Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp
785                 790                 795                 800 
Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp
                805                 810                 815     
Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val
            820                 825                 830         
Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser
        835                 840                 845             
Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser
    850                 855                 860                 
His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val
865                 870                 875                 880 
Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His
                885                 890                 895     
Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly
            900                 905                 910         
Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys
        915                 920                 925             
Lys Cys
    930 


<210> 8743
<211> 121
<212> PRT
<213> Homo sapiens

<400> 8743
Met Val Ser Arg Glu Gly Arg Arg Thr Leu Met Glu Leu Trp Gly Leu
 1               5                  10                  15      
Leu Pro Gly Ala Ala Ser Ser Leu Cys Ser Pro His Pro Gly Thr Val
            20                  25                  30          
Leu Leu Gly Cys Arg Ser Cys Gly Ser Ser Gly Pro Arg Cys Ser Leu
        35                  40                  45              
Val Pro Ala Leu Glu Gly Lys Val Val Asn Leu Ser Ile His Met Val
    50                  55                  60                  
Leu Ile Leu Gln Val Cys Arg Val His Lys Met Trp Lys His Gly Ile
65                  70                  75                  80  
Leu Gln Arg Asp Phe Phe Phe Phe Phe Phe Glu Thr Asp Ser His Cys
                85                  90                  95      
Ile Ala Gln Ala Gly Val Gln Trp Cys Asp Leu Gly Pro Pro Gln Pro
            100                 105                 110         
Pro Pro Tyr Ser Ile Ile Ile Pro Leu
        115                 120     


<210> 8744
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 8744
Met Ala Gly Ala Gly Gly Gln His His Pro Pro Gly Ala Ala Gly Gly
 1               5                  10                  15      
Ala Ala Ala Gly Ala Gly Ala Ala Val Thr Ser Ala Ala Ala Ser Ala
            20                  25                  30          
Gly Pro Gly Glu Asp Ser Ser Asp Ser Glu Ala Glu Gln Glu Gly Pro
        35                  40                  45              
Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln Ile Arg Thr Lys
    50                  55                  60                  
Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Ser Phe Gln
65                  70                  75                  80  
Arg Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr
                85                  90                  95      
Ala Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp
            100                 105                 110         
Ala Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr
        115                 120                 125             
Ile Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys
    130                 135                 140                 
Glu Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu
145                 150                 155                 160 
Pro Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His
                165                 170                 175     
Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys
            180                 185                 190         
Arg Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val
        195                 200                 205             
Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn
    210                 215                 220                 
Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp
225                 230                 235                 240 
Glu Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro
                245                 250                 255     
Val Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu
            260                 265                 270         
Arg Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr
        275                 280                 285             
Ala Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys
    290                 295                 300                 
Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly
305                 310                 315                 320 
Phe Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe
                325                 330                 335     
Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg
            340                 345                 350         
Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly
        355                 360                 365             
Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg
    370                 375                 380                 
Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu
385                 390                 395                 400 
Ile Asp Lys Leu Asn Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro
                405                 410                 415     
Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser
            420                 425                 430         
Tyr Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg
        435                 440                 445             
Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu
    450                 455                 460                 
Lys Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser
465                 470                 475                 480 
Glu Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu
                485                 490                 495     
Thr Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser Ala
            500                 505                 510         
Lys Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys
        515                 520                 525             
Thr Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala
    530                 535                 540                 
Ser Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala
545                 550                 555                 560 
Leu His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro
                565                 570                 575     
Leu Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu
            580                 585                 590         
Gly Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser
        595                 600                 605             
Gln Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu
    610                 615                 620                 
Lys Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp
625                 630                 635                 640 
Asp Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr
                645                 650                 655     
Asp Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Gly
            660                 665                 670         
Ala Lys Glu Ser Ile Thr Val Lys Thr Ala Pro Arg Ser Pro Asp Ala
        675                 680                 685             
Arg Ala Ser Tyr Gly His Ser Gln Thr Asp Ser Val Pro Gly Pro Ala
    690                 695                 700                 
Val Ala Ala Ser Lys Glu Asn Leu Pro Val Leu Asn Thr Arg Ile Ile
705                 710                 715                 720 
Cys Pro Gly Leu Arg Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser Ser
                725                 730                 735     
Ile Ile Asn Lys Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr
            740                 745                 750         
Pro Phe Ile Asp Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys
        755                 760                 765             
Cys Val Met Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser
    770                 775                 780                 
Leu Glu Phe Asn Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser
785                 790                 795                 800 
Arg Thr Lys Asn Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu
                805                 810                 815     
Leu Gln Arg Ser Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys
            820                 825                 830         
Asp Gly Gln Tyr Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu
        835                 840                 845             
Asn Ile Pro Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys
    850                 855                 860                 
Glu Asp Asp Ile Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu
865                 870                 875                 880 
Val Val Ala Ile Phe Asp Ser Met Gln Met Ala Val Ser Arg Val Ile
                885                 890                 895     
Lys Leu Gln His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr
            900                 905                 910         
Ile Phe Gly Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp
        915                 920                 925             
Val Gln Pro Pro Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln
    930                 935                 940                 
Met Leu Thr Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu
945                 950                 955                 960 
Asp Lys Gln Lys Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu
                965                 970                 975     
Tyr Ile His His Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met
            980                 985                 990         
Gln Leu Cys Ser Gln Ala Ala Glu Glu Leu Ile Thr Arg Ile Cys Asp
        995                 1000                1005            
Ala Ala Thr Ile His Cys Leu Leu Glu Gln Glu Leu Ala His Ala Val
    1010                1015                1020                
Asn Ala Cys Ser His Ala Leu Asn Lys Ala Asn Pro Arg Cys Pro Glu
1025                1030                1035                1040
Ser Leu Thr Arg Asp Thr Ala Thr Glu Ile Ala Ile Asn Val Lys Ala
                1045                1050                1055    
Leu Tyr Asn Glu Thr Glu Ser Leu Leu Val Gly Arg Val Pro Leu Gln
            1060                1065                1070        
Leu Glu Ser Pro His Glu Glu Arg Val Ser Asn Ala Leu His Ser Val
        1075                1080                1085            
Glu Val Glu Leu Gln Lys Leu Thr Glu Ile Pro Trp Leu Tyr Tyr Ile
    1090                1095                1100                
Leu His Pro Asn Glu Asp Glu Glu Pro Pro Met Asp Cys Thr Lys Arg
1105                1110                1115                1120
Asn Asn Arg Ser Thr Val Phe Arg Ile Val Pro Lys Phe Lys Lys Glu
                1125                1130                1135    
Lys Val Gln Lys Gln Lys Thr Ser Ser Gln Pro Gly Ser Gly Asp Thr
            1140                1145                1150        
Glu Ser Gly Ser Cys Glu Ala Asn Ser Pro Gly Asn
        1155                1160                


<210> 8745
<211> 1120
<212> PRT
<213> Homo sapiens

<400> 8745
Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Ser Phe Gln
 1               5                  10                  15      
Arg Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr
            20                  25                  30          
Ala Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp
        35                  40                  45              
Ala Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr
    50                  55                  60                  
Ile Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys
65                  70                  75                  80  
Glu Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu
                85                  90                  95      
Pro Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His
            100                 105                 110         
Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys
        115                 120                 125             
Arg Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val
    130                 135                 140                 
Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn
145                 150                 155                 160 
Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp
                165                 170                 175     
Glu Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro
            180                 185                 190         
Val Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu
        195                 200                 205             
Arg Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr
    210                 215                 220                 
Ala Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys
225                 230                 235                 240 
Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly
                245                 250                 255     
Phe Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe
            260                 265                 270         
Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg
        275                 280                 285             
Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly
    290                 295                 300                 
Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg
305                 310                 315                 320 
Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu
                325                 330                 335     
Ile Asp Lys Leu Asn Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro
            340                 345                 350         
Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser
        355                 360                 365             
Tyr Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg
    370                 375                 380                 
Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu
385                 390                 395                 400 
Lys Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser
                405                 410                 415     
Glu Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu
            420                 425                 430         
Thr Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser Ala
        435                 440                 445             
Lys Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys
    450                 455                 460                 
Thr Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala
465                 470                 475                 480 
Ser Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala
                485                 490                 495     
Leu His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro
            500                 505                 510         
Leu Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu
        515                 520                 525             
Gly Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser
    530                 535                 540                 
Gln Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu
545                 550                 555                 560 
Lys Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp
                565                 570                 575     
Asp Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr
            580                 585                 590         
Asp Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Val
        595                 600                 605             
Lys Thr Ala Pro Arg Ser Pro Asp Ala Arg Ala Ser Tyr Gly His Ser
    610                 615                 620                 
Gln Thr Asp Ser Val Pro Gly Pro Ala Val Ala Ala Ser Lys Glu Asn
625                 630                 635                 640 
Leu Pro Val Leu Asn Thr Arg Ile Ile Cys Pro Gly Leu Arg Ala Gly
                645                 650                 655     
Leu Ala Ala Ser Ile Ala Gly Ser Ser Ile Ile Asn Lys Met Leu Leu
            660                 665                 670         
Ala Asn Ile Asp Pro Phe Gly Ala Thr Pro Phe Ile Asp Pro Asp Leu
        675                 680                 685             
Asp Ser Val Asp Gly Tyr Ser Glu Lys Cys Val Met Asn Asn Tyr Phe
    690                 695                 700                 
Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Glu Phe Asn Asn Lys Arg
705                 710                 715                 720 
Glu Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys Asn Leu Met Trp
                725                 730                 735     
Tyr Gly Val Leu Gly Thr Arg Glu Leu Leu Gln Arg Ser Tyr Lys Asn
            740                 745                 750         
Leu Glu Gln Arg Val Gln Leu Glu Cys Asp Gly Gln Tyr Ile Pro Leu
        755                 760                 765             
Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro Ser Tyr Ala Gly
    770                 775                 780                 
Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp Ile Phe Ala Ala
785                 790                 795                 800 
Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala Ile Phe Asp Ser
                805                 810                 815     
Met Gln Met Ala Val Ser Arg Val Ile Lys Leu Gln His His Arg Ile
            820                 825                 830         
Ala Gln Cys Arg Thr Val Lys Ile Thr Ile Phe Gly Asp Glu Gly Val
        835                 840                 845             
Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro Gly Ile Ile
    850                 855                 860                 
Lys Ile Val His Lys Asn Arg Ala Gln Met Leu Thr Arg Asp Arg Ala
865                 870                 875                 880 
Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln Lys Cys Asp Ser
                885                 890                 895     
Gly Lys Pro Val Leu Arg Thr His Leu Tyr Ile His His Ala Ile Asp
            900                 905                 910         
Leu Ala Thr Glu Glu Val Ser Gln Met Gln Leu Cys Ser Gln Ala Ala
        915                 920                 925             
Glu Glu Leu Ile Thr Arg Ile Cys Asp Ala Ala Thr Ile His Cys Leu
    930                 935                 940                 
Leu Glu Gln Glu Leu Ala His Ala Val Asn Ala Cys Ser His Ala Leu
945                 950                 955                 960 
Asn Lys Ala Asn Pro Arg Cys Pro Glu Ser Leu Thr Arg Asp Thr Ala
                965                 970                 975     
Thr Glu Ile Ala Ile Asn Val Lys Ala Leu Tyr Asn Glu Thr Glu Ser
            980                 985                 990         
Leu Leu Val Gly Arg Val Pro Leu Gln Leu Glu Ser Pro His Glu Glu
        995                 1000                1005            
Arg Val Ser Asn Ala Leu His Ser Val Glu Val Glu Leu Gln Lys Leu
    1010                1015                1020                
Thr Glu Ile Pro Trp Leu Tyr Tyr Ile Leu His Pro Asn Glu Asp Glu
1025                1030                1035                1040
Glu Pro Pro Met Asp Cys Thr Lys Arg Asn Asn Arg Ser Thr Val Phe
                1045                1050                1055    
Arg Ile Val Pro Lys Phe Lys Lys Glu Lys Val Gln Lys Gln Lys Thr
            1060                1065                1070        
Ser Ser Gln Pro Val Gln Lys Trp Gly Thr Glu Glu Val Ala Ala Trp
        1075                1080                1085            
Leu Asp Leu Leu Asn Leu Gly Glu Tyr Lys Asp Ile Phe Ile Arg His
    1090                1095                1100                
Asp Ile Arg Gly Ala Glu Leu Leu His Leu Glu Arg Arg Asp Leu Lys
1105                1110                1115                1120


<210> 8746
<211> 1221
<212> PRT
<213> Homo sapiens

<400> 8746
Met Ala Gly Ala Gly Gly Gln His His Pro Pro Gly Ala Ala Gly Gly
 1               5                  10                  15      
Ala Ala Ala Gly Ala Gly Ala Ala Val Thr Ser Ala Ala Ala Ser Ala
            20                  25                  30          
Gly Pro Gly Glu Asp Ser Ser Asp Ser Glu Ala Glu Gln Glu Gly Pro
        35                  40                  45              
Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln Ile Arg Thr Lys
    50                  55                  60                  
Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Ser Phe Gln
65                  70                  75                  80  
Arg Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr
                85                  90                  95      
Ala Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp
            100                 105                 110         
Ala Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr
        115                 120                 125             
Ile Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys
    130                 135                 140                 
Glu Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu
145                 150                 155                 160 
Pro Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His
                165                 170                 175     
Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys
            180                 185                 190         
Arg Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val
        195                 200                 205             
Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn
    210                 215                 220                 
Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp
225                 230                 235                 240 
Glu Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro
                245                 250                 255     
Val Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu
            260                 265                 270         
Arg Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr
        275                 280                 285             
Ala Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys
    290                 295                 300                 
Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly
305                 310                 315                 320 
Phe Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe
                325                 330                 335     
Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg
            340                 345                 350         
Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly
        355                 360                 365             
Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg
    370                 375                 380                 
Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu
385                 390                 395                 400 
Ile Asp Lys Leu Asn Leu Asn Lys Gln Ala Met Gln Leu Gly Val Leu
                405                 410                 415     
Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly
            420                 425                 430         
Ser Tyr Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu
        435                 440                 445             
Arg Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu
    450                 455                 460                 
Leu Lys Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala
465                 470                 475                 480 
Ser Glu Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His
                485                 490                 495     
Leu Thr Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser
            500                 505                 510         
Ala Lys Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu
        515                 520                 525             
Lys Thr Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val
    530                 535                 540                 
Ala Ser Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln
545                 550                 555                 560 
Ala Leu His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser
                565                 570                 575     
Pro Leu Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser
            580                 585                 590         
Leu Gly Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser
        595                 600                 605             
Ser Gln Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser
    610                 615                 620                 
Leu Lys Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met
625                 630                 635                 640 
Asp Asp Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp
                645                 650                 655     
Tyr Asp Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp
            660                 665                 670         
Gly Ala Lys Glu Ser Ile Thr Val Lys Thr Ala Pro Arg Ser Pro Asp
        675                 680                 685             
Ala Arg Ala Ser Tyr Gly His Ser Gln Thr Asp Ser Val Pro Gly Pro
    690                 695                 700                 
Ala Val Ala Ala Ser Lys Glu Asn Leu Pro Val Leu Asn Thr Arg Ile
705                 710                 715                 720 
Ile Cys Pro Gly Leu Arg Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser
                725                 730                 735     
Ser Ile Ile Asn Lys Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala
            740                 745                 750         
Thr Pro Phe Ile Asp Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu
        755                 760                 765             
Lys Cys Val Met Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile
    770                 775                 780                 
Ser Leu Glu Phe Asn Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg
785                 790                 795                 800 
Ser Arg Thr Lys Asn Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu
                805                 810                 815     
Leu Leu Gln Arg Ser Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu
            820                 825                 830         
Cys Asp Gly Gln Tyr Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val
        835                 840                 845             
Leu Asn Ile Pro Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr
    850                 855                 860                 
Lys Glu Asp Asp Ile Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu
865                 870                 875                 880 
Glu Val Val Ala Ile Phe Asp Ser Met Gln Met Ala Val Ser Arg Val
                885                 890                 895     
Ile Lys Leu Gln His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile
            900                 905                 910         
Thr Ile Phe Gly Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala
        915                 920                 925             
Trp Val Gln Pro Pro Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala
    930                 935                 940                 
Gln Met Leu Thr Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp
945                 950                 955                 960 
Glu Asp Lys Gln Lys Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His
                965                 970                 975     
Leu Tyr Ile His His Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln
            980                 985                 990         
Met Gln Leu Cys Ser Gln Ala Ala Glu Glu Leu Ile Thr Arg Ile Cys
        995                 1000                1005            
Asp Ala Ala Thr Ile His Cys Leu Leu Glu Gln Glu Leu Ala His Ala
    1010                1015                1020                
Val Asn Ala Cys Ser His Ala Leu Asn Lys Ala Asn Pro Arg Cys Pro
1025                1030                1035                1040
Glu Ser Leu Thr Arg Asp Thr Ala Thr Glu Ile Ala Ile Asn Val Lys
                1045                1050                1055    
Ala Leu Tyr Asn Glu Thr Glu Ser Leu Leu Val Gly Arg Val Pro Leu
            1060                1065                1070        
Gln Leu Glu Ser Pro His Glu Glu Arg Val Ser Asn Ala Leu His Ser
        1075                1080                1085            
Val Glu Val Glu Leu Gln Lys Leu Thr Glu Ile Pro Trp Leu Tyr Tyr
    1090                1095                1100                
Ile Leu His Pro Asn Glu Asp Glu Glu Pro Pro Met Asp Cys Thr Lys
1105                1110                1115                1120
Arg Asn Asn Arg Ser Thr Val Phe Arg Ile Val Pro Lys Phe Lys Lys
                1125                1130                1135    
Glu Lys Val Gln Lys Gln Lys Thr Ser Ser Gln Pro Val Gln Lys Trp
            1140                1145                1150        
Gly Thr Glu Glu Val Ala Ala Trp Leu Asp Leu Leu Asn Leu Gly Glu
        1155                1160                1165            
Tyr Lys Asp Ile Phe Ile Arg His Asp Ile Arg Gly Ala Glu Leu Leu
    1170                1175                1180                
His Leu Glu Arg Arg Asp Leu Lys Asp Leu Gly Ile Pro Lys Val Gly
1185                1190                1195                1200
His Val Lys Arg Ile Leu Gln Gly Ile Lys Glu Leu Gly Arg Ser Thr
                1205                1210                1215    
Pro Gln Ser Glu Val
            1220    


<210> 8747
<211> 4641
<212> PRT
<213> Homo sapiens

<400> 8747
Met Pro Val Pro Asp Gly Ser Val Ala Ala Ala Gly Leu Gly Leu Gly
 1               5                  10                  15      
Leu Pro Ala Ala Asp Ser Pro Gly His Tyr Gln Leu Leu Leu Ser Gly
            20                  25                  30          
Arg Ala Leu Ala Asp Arg Tyr Arg Arg Ile Tyr Thr Ala Ala Leu Asn
        35                  40                  45              
Asp Arg Asp Gln Gly Gly Gly Ser Ala Gly His Pro Ala Ser Arg Asn
    50                  55                  60                  
Lys Lys Ile Leu Asn Lys Lys Lys Leu Lys Arg Lys Gln Lys Ser Lys
65                  70                  75                  80  
Ser Lys Val Lys Thr Arg Ser Lys Ser Glu Asn Leu Glu Asn Thr Val
                85                  90                  95      
Ile Ile Pro Asp Ile Lys Leu His Ser Asn Pro Ser Ala Phe Asn Ile
            100                 105                 110         
Tyr Cys Asn Val Arg His Cys Val Leu Glu Trp Gln Lys Lys Glu Ile
        115                 120                 125             
Ser Leu Ala Ala Ala Ser Lys Asn Ser Val Gln Ser Gly Glu Ser Asp
    130                 135                 140                 
Ser Asp Glu Glu Glu Glu Ser Lys Glu Pro Pro Ile Lys Leu Pro Lys
145                 150                 155                 160 
Ile Ile Glu Val Gly Leu Cys Glu Val Phe Glu Leu Ile Lys Glu Thr
                165                 170                 175     
Arg Phe Ser His Pro Ser Leu Cys Leu Arg Ser Leu Gln Ala Leu Leu
            180                 185                 190         
Asn Val Leu Gln Gly Gln Gln Pro Glu Val Leu Gln Ser Glu Pro Pro
        195                 200                 205             
Glu Val Leu Glu Ser Leu Phe Gln Leu Leu Leu Glu Ile Thr Val Arg
    210                 215                 220                 
Ser Thr Gly Met Asn Asp Ser Thr Gly Gln Ser Leu Thr Ala Leu Ser
225                 230                 235                 240 
Cys Ala Cys Leu Phe Ser Leu Val Ala Ser Trp Gly Glu Thr Gly Arg
                245                 250                 255     
Thr Leu Gln Ala Ile Ser Ala Ile Leu Thr Asn Asn Gly Ser His Ala
            260                 265                 270         
Cys Gln Thr Ile Gln Val Pro Thr Ile Leu Asn Ser Leu Gln Arg Ser
        275                 280                 285             
Val Gln Ala Val Leu Val Gly Lys Ile Gln Ile Gln Asp Trp Phe Ser
    290                 295                 300                 
Asn Gly Ile Lys Lys Ala Ala Leu Met His Lys Trp Pro Leu Lys Glu
305                 310                 315                 320 
Ile Ser Val Asp Glu Asp Asp Gln Cys Leu Leu Gln Asn Asp Gly Phe
                325                 330                 335     
Phe Leu Tyr Leu Leu Cys Lys Asp Gly Leu Tyr Lys Ile Gly Ser Gly
            340                 345                 350         
Tyr Ser Gly Thr Val Arg Gly His Ile Tyr Asn Ser Thr Ser Arg Ile
        355                 360                 365             
Arg Asn Arg Lys Glu Lys Lys Ser Trp Leu Gly Tyr Ala Gln Gly Tyr
    370                 375                 380                 
Leu Leu Tyr Arg Asp Val Asn Asn His Ser Met Thr Ala Ile Arg Ile
385                 390                 395                 400 
Ser Pro Glu Thr Leu Glu Gln Asp Gly Thr Val Met Leu Pro Asp Cys
                405                 410                 415     
His Thr Glu Gly Gln Asn Ile Leu Phe Thr Asp Gly Glu Tyr Ile Asn
            420                 425                 430         
Gln Ile Ala Ala Ser Arg Asp Asp Gly Phe Val Val Arg Ile Phe Ala
        435                 440                 445             
Thr Ser Thr Glu Pro Val Leu Gln Gln Glu Leu Gln Leu Lys Leu Ala
    450                 455                 460                 
Arg Lys Cys Leu His Ala Cys Arg Ile Ser Leu Phe Asp Leu Glu Lys
465                 470                 475                 480 
Asp Leu His Ile Ile Ser Thr Gly Phe Asp Glu Glu Ser Ala Ile Leu
                485                 490                 495     
Gly Ala Gly Arg Glu Phe Ala Leu Met Lys Thr Ala Asn Gly Lys Ile
            500                 505                 510         
Tyr Tyr Thr Gly Lys Tyr Gln Ser Leu Gly Ile Lys Gln Gly Gly Pro
        515                 520                 525             
Ser Ala Gly Lys Trp Val Glu Leu Pro Ile Thr Lys Ser Pro Lys Ile
    530                 535                 540                 
Val His Phe Ser Val Gly His Asp Gly Ser His Ala Leu Leu Val Ala
545                 550                 555                 560 
Glu Asp Gly Ser Ile Phe Phe Thr Gly Ser Ala Ser Lys Gly Glu Asp
                565                 570                 575     
Gly Glu Ser Ile Lys Ser Arg Arg Gln Ser Lys Pro Tyr Lys Pro Lys
            580                 585                 590         
Lys Ile Ile Lys Met Glu Gly Lys Ile Val Val Tyr Thr Ala Cys Asn
        595                 600                 605             
Asn Gly Ser Ser Ser Val Ile Ser Lys Asp Gly Glu Leu Tyr Met Phe
    610                 615                 620                 
Gly Lys Asp Ala Ile Tyr Ser Asp Ser Ser Ser Leu Val Thr Asp Leu
625                 630                 635                 640 
Lys Gly His Phe Val Thr Gln Val Ala Met Gly Lys Ala His Thr Cys
                645                 650                 655     
Val Leu Met Lys Asn Gly Glu Val Trp Thr Phe Gly Val Asn Asn Lys
            660                 665                 670         
Gly Gln Cys Gly Arg Asp Thr Gly Ala Met Asn Gln Gly Gly Lys Gly
        675                 680                 685             
Phe Gly Val Glu Asn Met Ala Thr Ala Met Asp Glu Asp Leu Glu Glu
    690                 695                 700                 
Glu Leu Asp Glu Lys Asp Glu Lys Ser Met Met Cys Pro Pro Gly Met
705                 710                 715                 720 
His Lys Trp Lys Leu Glu Gln Cys Met Val Cys Thr Val Cys Gly Asp
                725                 730                 735     
Cys Thr Gly Tyr Gly Ala Ser Cys Val Ser Ser Gly Arg Pro Asp Arg
            740                 745                 750         
Val Pro Gly Gly Ile Cys Gly Cys Gly Ser Gly Glu Ser Gly Cys Ala
        755                 760                 765             
Val Cys Gly Cys Cys Lys Ala Cys Ala Arg Glu Leu Asp Gly Gln Glu
    770                 775                 780                 
Ala Arg Gln Arg Gly Ile Leu Asp Ala Val Lys Glu Met Ile Pro Leu
785                 790                 795                 800 
Asp Leu Leu Leu Ala Val Pro Val Pro Gly Val Asn Ile Glu Glu His
                805                 810                 815     
Leu Gln Leu Arg Gln Glu Glu Lys Arg Gln Arg Val Ile Arg Arg His
            820                 825                 830         
Arg Leu Glu Glu Gly Arg Gly Pro Leu Val Phe Ala Gly Pro Ile Phe
        835                 840                 845             
Met Asn His Arg Glu Gln Ala Leu Ala Arg Leu Arg Ser His Pro Ala
    850                 855                 860                 
His Val Lys His Lys Arg Asp Lys His Lys Asp Gly Ser Gly Glu Arg
865                 870                 875                 880 
Gly Glu Lys Asp Ala Ser Lys Ile Thr Thr Tyr Pro Pro Gly Ser Val
                885                 890                 895     
Arg Phe Asp Cys Glu Leu Arg Ala Val Gln Val Ser Cys Gly Phe His
            900                 905                 910         
His Ser Val Val Leu Met Glu Asn Gly Asp Val Tyr Thr Phe Gly Tyr
        915                 920                 925             
Gly Gln His Gly Gln Leu Gly His Gly Asp Val Asn Ser Arg Gly Cys
    930                 935                 940                 
Pro Thr Leu Val Gln Ala Leu Pro Gly Pro Ser Thr Gln Val Thr Ala
945                 950                 955                 960 
Gly Ser Asn His Thr Ala Val Leu Leu Met Asp Gly Gln Val Phe Thr
                965                 970                 975     
Phe Gly Ser Phe Ser Lys Gly Gln Leu Gly Arg Pro Ile Leu Asp Val
            980                 985                 990         
Pro Tyr Trp Asn Ala Lys Pro Ala Pro Met Pro Asn Ile Gly Ser Lys
        995                 1000                1005            
Tyr Gly Arg Lys Ala Thr Trp Ile Gly Ala Ser Gly Asp Gln Thr Phe
    1010                1015                1020                
Leu Arg Ile Asp Glu Ala Leu Ile Asn Ser His Val Leu Ala Thr Ser
1025                1030                1035                1040
Glu Ile Phe Ala Ser Lys His Ile Ile Gly Leu Val Pro Ala Ser Ile
                1045                1050                1055    
Ser Glu Pro Pro Pro Phe Lys Cys Leu Leu Ile Asn Lys Val Asp Gly
            1060                1065                1070        
Ser Cys Lys Thr Phe Asn Asp Ser Glu Gln Glu Asp Leu Gln Gly Phe
        1075                1080                1085            
Gly Val Cys Leu Asp Pro Val Tyr Asp Val Ile Trp Arg Phe Arg Pro
    1090                1095                1100                
Asn Thr Arg Glu Leu Trp Cys Tyr Asn Ala Val Val Ala Asp Ala Arg
1105                1110                1115                1120
Leu Pro Ser Ala Ala Asp Met Gln Ser Arg Cys Ser Ile Leu Ser Pro
                1125                1130                1135    
Glu Leu Ala Leu Pro Thr Gly Ser Arg Ala Leu Thr Thr Arg Ser His
            1140                1145                1150        
Ala Ala Leu His Ile Leu Gly Cys Leu Asp Thr Leu Ala Ala Met Gln
        1155                1160                1165            
Asp Leu Lys Met Gly Val Ala Ser Thr Glu Glu Glu Thr Gln Ala Val
    1170                1175                1180                
Met Lys Val Tyr Ser Lys Glu Asp Tyr Ser Val Val Asn Arg Phe Glu
1185                1190                1195                1200
Ser His Gly Gly Gly Trp Gly Tyr Ser Ala His Ser Val Glu Ala Ile
                1205                1210                1215    
Arg Phe Ser Ala Asp Thr Asp Ile Leu Leu Gly Gly Leu Gly Leu Phe
            1220                1225                1230        
Gly Gly Arg Gly Glu Tyr Thr Ala Lys Ile Lys Leu Phe Glu Leu Gly
        1235                1240                1245            
Pro Asp Gly Gly Asp His Glu Thr Asp Gly Asp Leu Leu Ala Glu Thr
    1250                1255                1260                
Asp Val Leu Ala Tyr Asp Cys Ala Ala Arg Glu Lys Tyr Ala Met Met
1265                1270                1275                1280
Phe Asp Glu Pro Val Leu Leu Gln Ala Gly Trp Trp Tyr Val Ala Trp
                1285                1290                1295    
Ala Arg Val Ser Gly Pro Ser Ser Asp Cys Gly Ser His Gly Gln Ala
            1300                1305                1310        
Ser Ile Thr Thr Asp Asp Gly Val Val Phe Gln Phe Lys Ser Ser Lys
        1315                1320                1325            
Lys Ser Asn Asn Gly Thr Asp Val Asn Ala Gly Gln Ile Pro Gln Leu
    1330                1335                1340                
Leu Tyr Arg Leu Pro Thr Ser Asp Gly Ser Ala Ser Lys Gly Lys Gln
1345                1350                1355                1360
Gln Thr Ser Glu Pro Val His Ile Leu Lys Arg Ser Phe Ala Arg Thr
                1365                1370                1375    
Val Ser Val Glu Cys Phe Glu Ser Leu Leu Ser Ile Leu His Trp Ser
            1380                1385                1390        
Trp Thr Thr Leu Val Leu Gly Val Glu Glu Leu Arg Gly Leu Lys Gly
        1395                1400                1405            
Phe Gln Phe Thr Ala Thr Leu Leu Asp Leu Glu Arg Leu Arg Phe Val
    1410                1415                1420                
Gly Thr Cys Cys Leu Arg Leu Leu Arg Val Tyr Thr Cys Glu Ile Tyr
1425                1430                1435                1440
Pro Val Ser Ala Thr Gly Lys Ala Val Val Glu Glu Thr Ser Lys Leu
                1445                1450                1455    
Ala Glu Cys Ile Gly Lys Thr Arg Thr Leu Leu Arg Lys Ile Leu Ser
            1460                1465                1470        
Glu Pro Leu Asp His Cys Met Val Lys Leu Asp Asn Asp Pro Gln Gly
        1475                1480                1485            
Tyr Leu Ser Gln Pro Leu Ser Leu Leu Glu Ala Val Leu Gln Glu Cys
    1490                1495                1500                
His Asn Thr Phe Thr Ala Cys Phe His Ser Phe Tyr Pro Thr Pro Ala
1505                1510                1515                1520
Leu Gln Trp Ala Cys Leu Cys Asp Leu Leu Asn Cys Leu Asp Gln Asp
                1525                1530                1535    
Ile Gln Glu Ala Asn Phe Lys Thr Ser Ser Ser Arg Leu Leu Ala Ala
            1540                1545                1550        
Val Met Ser Ala Leu Cys His Thr Ser Val Lys Leu Thr Ser Ile Phe
        1555                1560                1565            
Pro Ile Ala Tyr Asp Gly Glu Val Leu Leu Arg Ser Ile Val Lys Gln
    1570                1575                1580                
Val Ser Thr Glu Asn Asp Ser Thr Leu Val His Arg Phe Pro Leu Leu
1585                1590                1595                1600
Val Ala His Met Glu Lys Leu Ser Gln Ser Glu Glu Asn Ile Ser Gly
                1605                1610                1615    
Met Thr Ser Phe Arg Glu Val Leu Glu Lys Met Leu Val Ile Val Val
            1620                1625                1630        
Leu Pro Val Arg Asn Ser Leu Arg Arg Glu Asn Glu Leu Phe Ser Ser
        1635                1640                1645            
His Leu Val Ser Asn Thr Cys Gly Leu Leu Ala Ser Ile Val Ser Glu
    1650                1655                1660                
Leu Thr Ala Ser Ala Leu Gly Ser Glu Val Asp Gly Leu Asn Ser Leu
1665                1670                1675                1680
His Ser Val Lys Ala Ser Ala Asn Arg Phe Thr Lys Thr Ser Gln Gly
                1685                1690                1695    
Arg Ser Trp Asn Thr Gly Asn Gly Ser Pro Asp Ala Ile Cys Phe Ser
            1700                1705                1710        
Val Asp Lys Pro Gly Ile Val Val Val Gly Phe Ser Val Tyr Gly Gly
        1715                1720                1725            
Gly Gly Ile His Glu Tyr Glu Leu Glu Val Leu Val Asp Asp Ser Glu
    1730                1735                1740                
His Ala Gly Asp Ser Thr His Ser His Arg Trp Thr Ser Leu Glu Leu
1745                1750                1755                1760
Val Lys Gly Thr Tyr Thr Thr Asp Asp Ser Pro Ser Asp Ile Ala Glu
                1765                1770                1775    
Ile Arg Leu Asp Lys Val Val Pro Leu Lys Glu Asn Val Lys Tyr Ala
            1780                1785                1790        
Val Arg Leu Arg Asn Tyr Gly Ser Arg Thr Ala Asn Gly Asp Gly Gly
        1795                1800                1805            
Met Thr Thr Val Gln Cys Pro Asp Gly Val Thr Phe Thr Phe Ser Thr
    1810                1815                1820                
Cys Ser Leu Ser Ser Asn Gly Thr Asn Gln Thr Arg Gly Gln Ile Pro
1825                1830                1835                1840
Gln Ile Leu Tyr Tyr Arg Ser Glu Phe Asp Gly Asp Leu Gln Ser Gln
                1845                1850                1855    
Leu Leu Ser Lys Ala Asn Glu Glu Asp Lys Asn Cys Ser Arg Ala Leu
            1860                1865                1870        
Ser Val Val Ser Thr Val Val Arg Ala Ser Lys Asp Leu Leu His Arg
        1875                1880                1885            
Ala Leu Ala Val Asp Ala Asp Asp Ile Pro Glu Leu Leu Ser Ser Ser
    1890                1895                1900                
Ser Leu Phe Ser Met Leu Leu Pro Leu Ile Ile Ala Tyr Ile Gly Pro
1905                1910                1915                1920
Val Ala Ala Ala Ile Pro Lys Val Ala Val Glu Val Phe Gly Leu Val
                1925                1930                1935    
Gln Gln Leu Leu Pro Ser Val Ala Ile Leu Asn Gln Lys Tyr Ala Pro
            1940                1945                1950        
Pro Ala Phe Asn Pro Asn Gln Ser Thr Asp Ser Thr Thr Gly Asn Gln
        1955                1960                1965            
Pro Glu Gln Gly Leu Ser Ala Cys Thr Thr Ser Ser His Tyr Ala Val
    1970                1975                1980                
Ile Glu Ser Glu His Pro Tyr Lys Pro Ala Cys Val Met His Tyr Lys
1985                1990                1995                2000
Val Thr Phe Pro Glu Cys Val Arg Trp Met Thr Ile Glu Phe Asp Pro
                2005                2010                2015    
Gln Cys Gly Thr Ala Gln Ser Glu Asp Val Leu Arg Leu Leu Ile Pro
            2020                2025                2030        
Val Arg Thr Val Gln Asn Ser Gly Tyr Gly Pro Lys Leu Thr Ser Val
        2035                2040                2045            
His Glu Asn Leu Asn Ser Trp Ile Glu Leu Lys Lys Phe Ser Gly Ser
    2050                2055                2060                
Ser Gly Trp Pro Thr Met Val Leu Val Leu Pro Gly Asn Glu Ala Leu
2065                2070                2075                2080
Phe Ser Leu Glu Thr Ala Ser Asp Tyr Val Lys Asp Asp Lys Ala Ser
                2085                2090                2095    
Phe Tyr Gly Phe Met Cys Phe Ala Ile Gly Tyr Glu Phe Ser Pro Gly
            2100                2105                2110        
Pro Asp Glu Gly Val Ile Gln Leu Glu Lys Glu Leu Ala Asn Leu Gly
        2115                2120                2125            
Gly Val Cys Ala Ala Ala Leu Met Lys Lys Asp Leu Ala Leu Pro Ile
    2130                2135                2140                
Gly Asn Glu Leu Glu Glu Asp Leu Glu Ile Leu Glu Glu Ala Ala Leu
2145                2150                2155                2160
Gln Val Cys Lys Thr His Ser Gly Ile Leu Gly Lys Gly Leu Ala Leu
                2165                2170                2175    
Ser His Ser Pro Thr Ile Leu Glu Ala Leu Glu Gly Asn Leu Pro Leu
            2180                2185                2190        
Gln Ile Gln Ser Asn Glu Gln Ser Phe Leu Asp Asp Phe Ile Ala Cys
        2195                2200                2205            
Val Pro Gly Ser Ser Gly Gly Arg Leu Ala Arg Trp Leu Gln Pro Asp
    2210                2215                2220                
Ser Tyr Ala Asp Pro Gln Lys Thr Ser Leu Ile Leu Asn Lys Asp Asp
2225                2230                2235                2240
Ile Arg Cys Gly Trp Pro Thr Thr Ile Thr Val Gln Thr Lys Asp Gln
                2245                2250                2255    
Tyr Gly Asp Val Val His Val Pro Asn Met Lys Val Glu Val Lys Ala
            2260                2265                2270        
Val Pro Val Ser Gln Lys Lys Met Ser Leu Gln Gln Asp Gln Ala Lys
        2275                2280                2285            
Lys Pro Gln Arg Ile Pro Gly Ser Pro Ala Val Thr Ala Ala Ser Ser
    2290                2295                2300                
Asn Thr Asp Met Thr Tyr Gly Gly Leu Ala Ser Pro Lys Leu Asp Val
2305                2310                2315                2320
Ser Tyr Glu Pro Met Ile Val Lys Glu Ala Arg Tyr Ile Ala Ile Thr
                2325                2330                2335    
Met Met Lys Val Tyr Glu Asn Tyr Ser Phe Glu Glu Leu Arg Phe Ala
            2340                2345                2350        
Ser Pro Thr Pro Lys Arg Pro Ser Glu Asn Met Leu Ile Arg Val Asn
        2355                2360                2365            
Asn Asp Gly Thr Tyr Cys Ala Asn Trp Thr Pro Gly Ala Ile Gly Leu
    2370                2375                2380                
Tyr Thr Leu His Val Thr Ile Asp Gly Ile Glu Ile Asp Ala Gly Leu
2385                2390                2395                2400
Glu Val Lys Val Lys Asp Pro Pro Lys Gly Met Ile Pro Pro Gly Thr
                2405                2410                2415    
Gln Leu Val Lys Pro Lys Ser Glu Pro Gln Pro Asn Lys Val Arg Lys
            2420                2425                2430        
Phe Val Ala Lys Asp Ser Ala Gly Leu Arg Ile Arg Ser His Pro Ser
        2435                2440                2445            
Leu Gln Ser Glu Gln Ile Gly Ile Val Lys Val Asn Gly Thr Ile Thr
    2450                2455                2460                
Phe Ile Asp Glu Ile His Asn Asp Asp Gly Val Trp Leu Arg Leu Asn
2465                2470                2475                2480
Asp Glu Thr Ile Lys Lys Tyr Val Pro Asn Met Asn Gly Tyr Thr Glu
                2485                2490                2495    
Ala Trp Cys Leu Ser Phe Asn Gln His Leu Gly Lys Ser Leu Leu Val
            2500                2505                2510        
Pro Val Asp Glu Ser Lys Thr Asn Thr Asp Asp Phe Phe Lys Asp Ile
        2515                2520                2525            
Asn Ser Cys Cys Pro Gln Glu Ala Thr Met Gln Glu Gln Asp Met Pro
    2530                2535                2540                
Phe Leu Arg Gly Gly Pro Gly Met Tyr Lys Val Val Lys Thr Gly Pro
2545                2550                2555                2560
Ser Gly His Asn Ile Arg Ser Cys Pro Asn Leu Arg Gly Ile Pro Ile
                2565                2570                2575    
Gly Met Leu Val Leu Gly Asn Lys Val Lys Ala Val Gly Glu Val Thr
            2580                2585                2590        
Asn Ser Glu Gly Thr Trp Val Gln Leu Asp Gln Asn Ser Met Val Glu
        2595                2600                2605            
Phe Cys Glu Ser Asp Glu Gly Glu Ala Trp Ser Leu Ala Arg Asp Arg
    2610                2615                2620                
Gly Gly Asn Gln Tyr Leu Arg His Glu Asp Glu Gln Ala Leu Leu Asp
2625                2630                2635                2640
Gln Asn Ser Gln Thr Pro Pro Pro Ser Pro Phe Ser Val Gln Ala Phe
                2645                2650                2655    
Asn Lys Gly Ala Ser Cys Ser Ala Gln Gly Phe Asp Tyr Gly Leu Gly
            2660                2665                2670        
Asn Ser Lys Gly Asp Arg Gly Asn Ile Ser Thr Ser Ser Lys Pro Ala
        2675                2680                2685            
Ser Thr Ser Gly Lys Ser Glu Leu Ser Ser Lys His Ser Arg Ser Leu
    2690                2695                2700                
Lys Pro Asp Gly Arg Met Ser Arg Thr Thr Ala Asp Gln Lys Lys Pro
2705                2710                2715                2720
Arg Gly Thr Glu Ser Leu Ser Ala Ser Glu Ser Leu Ile Leu Lys Ser
                2725                2730                2735    
Asp Ala Ala Lys Leu Arg Ser Asp Ser His Ser Arg Ser Leu Ser Pro
            2740                2745                2750        
Asn His Asn Thr Leu Gln Thr Leu Lys Ser Asp Gly Arg Met Pro Ser
        2755                2760                2765            
Ser Ser Arg Ala Glu Ser Pro Gly Pro Gly Ser Arg Leu Ser Ser Pro
    2770                2775                2780                
Lys Pro Lys Thr Leu Pro Ala Asn Arg Ser Ser Pro Ser Gly Ala Ser
2785                2790                2795                2800
Ser Pro Arg Ser Ser Ser Pro His Asp Lys Asn Leu Pro Gln Lys Ser
                2805                2810                2815    
Thr Ala Pro Val Lys Thr Lys Leu Asp Pro Pro Arg Glu Arg Ser Lys
            2820                2825                2830        
Ser Asp Ser Tyr Thr Leu Asp Pro Asp Thr Leu Arg Lys Lys Lys Met
        2835                2840                2845            
Pro Leu Thr Glu Pro Leu Arg Gly Arg Ser Thr Ser Pro Lys Pro Lys
    2850                2855                2860                
Ser Val Pro Lys Asp Ser Thr Asp Ser Pro Gly Ser Glu Asn Arg Ala
2865                2870                2875                2880
Pro Ser Pro His Val Val Gln Glu Asn Leu His Ser Glu Val Val Glu
                2885                2890                2895    
Val Cys Thr Ser Ser Thr Leu Lys Thr Asn Ser Leu Thr Asp Ser Thr
            2900                2905                2910        
Cys Asp Asp Ser Ser Glu Phe Lys Ser Val Asp Glu Gly Ser Asn Lys
        2915                2920                2925            
Val His Phe Ser Ile Gly Lys Ala Pro Leu Lys Asp Glu Gln Glu Met
    2930                2935                2940                
Arg Ala Ser Pro Lys Ile Ser Arg Lys Cys Ala Asn Arg His Thr Arg
2945                2950                2955                2960
Pro Lys Lys Glu Lys Ser Ser Phe Leu Phe Lys Gly Asp Gly Ser Lys
                2965                2970                2975    
Pro Leu Glu Pro Ala Lys Gln Ala Met Ser Pro Ser Val Ala Glu Cys
            2980                2985                2990        
Ala Arg Ala Val Phe Ala Ser Phe Leu Trp His Glu Gly Ile Val His
        2995                3000                3005            
Asp Ala Met Ala Cys Ser Ser Phe Leu Lys Phe His Pro Glu Leu Ser
    3010                3015                3020                
Lys Glu His Ala Pro Ile Arg Ser Ser Leu Asn Ser Gln Gln Pro Thr
3025                3030                3035                3040
Glu Glu Lys Glu Thr Lys Leu Lys Asn Arg His Ser Leu Glu Ile Ser
                3045                3050                3055    
Ser Ala Leu Asn Met Phe Asn Ile Ala Pro His Gly Pro Asp Ile Ser
            3060                3065                3070        
Lys Met Gly Ser Ile Asn Lys Asn Lys Val Leu Ser Met Leu Lys Glu
        3075                3080                3085            
Pro Pro Leu His Glu Lys Cys Glu Asp Gly Lys Thr Glu Thr Thr Phe
    3090                3095                3100                
Glu Met Ser Met His Asn Thr Met Lys Ser Lys Ser Pro Leu Pro Leu
3105                3110                3115                3120
Thr Leu Gln His Leu Val Ala Phe Trp Glu Asp Ile Ser Leu Ala Thr
                3125                3130                3135    
Ile Lys Ala Ala Ser Gln Asn Met Ile Phe Pro Ser Pro Gly Ser Cys
            3140                3145                3150        
Ala Val Leu Lys Lys Lys Glu Cys Glu Lys Gly Arg Asn Lys Lys Ser
        3155                3160                3165            
Lys Lys Glu Lys Lys Lys Lys Glu Lys Ala Glu Val Arg Pro Arg Gly
    3170                3175                3180                
Asn Leu Phe Gly Glu Met Ala Gln Leu Ala Val Gly Gly Pro Glu Lys
3185                3190                3195                3200
Asp Thr Ile Cys Glu Leu Cys Gly Glu Ser His Pro Tyr Pro Val Thr
                3205                3210                3215    
Tyr His Met Arg Gln Ala His Pro Gly Cys Gly Arg Tyr Ala Gly Gly
            3220                3225                3230        
Gln Gly Tyr Asn Ser Ile Gly His Phe Cys Gly Gly Trp Ala Gly Asn
        3235                3240                3245            
Cys Gly Asp Gly Gly Ile Gly Gly Ser Thr Trp Tyr Leu Val Cys Asp
    3250                3255                3260                
Arg Cys Arg Glu Lys Tyr Leu Arg Glu Lys Gln Ala Ala Ala Arg Glu
3265                3270                3275                3280
Lys Val Lys Gln Ser Arg Arg Lys Pro Met Gln Val Lys Thr Pro Arg
                3285                3290                3295    
Ala Leu Pro Thr Met Glu Ala His Gln Val Ile Lys Ala Asn Ala Leu
            3300                3305                3310        
Phe Leu Leu Ser Leu Ser Ser Ala Ala Glu Pro Ser Ile Leu Cys Tyr
        3315                3320                3325            
His Pro Ala Lys Pro Phe Gln Ser Gln Leu Pro Ser Val Lys Glu Gly
    3330                3335                3340                
Ile Ser Glu Asp Leu Pro Val Lys Met Pro Cys Leu Tyr Leu Gln Thr
3345                3350                3355                3360
Leu Ala Arg His His His Glu Asn Phe Val Gly Tyr Gln Asp Asp Asn
                3365                3370                3375    
Leu Phe Gln Asp Glu Met Arg Tyr Leu Arg Ser Thr Ser Val Pro Ala
            3380                3385                3390        
Pro Tyr Ile Ser Val Thr Pro Asp Ala Ser Pro Asn Val Phe Glu Glu
        3395                3400                3405            
Pro Glu Ser Asn Met Lys Ser Met Pro Pro Ser Leu Glu Thr Ser Pro
    3410                3415                3420                
Ile Thr Asp Thr Asp Leu Ala Lys Arg Thr Val Phe Gln Arg Ser Tyr
3425                3430                3435                3440
Ser Val Val Ala Ser Glu Tyr Asp Lys Gln His Ser Ile Leu Pro Ala
                3445                3450                3455    
Arg Val Lys Ala Ile Pro Arg Arg Arg Val Asn Ser Gly Asp Thr Glu
            3460                3465                3470        
Val Gly Ser Ser Leu Leu Arg His Pro Ser Pro Glu Leu Ser Arg Leu
        3475                3480                3485            
Ile Ser Ala His Ser Ser Leu Ser Lys Gly Glu Arg Asn Phe Gln Trp
    3490                3495                3500                
Pro Val Leu Ala Phe Val Ile Gln His His Asp Leu Glu Gly Leu Glu
3505                3510                3515                3520
Ile Ala Met Lys Gln Ala Leu Arg Lys Ser Ala Cys Arg Val Phe Ala
                3525                3530                3535    
Met Glu Ala Phe Asn Trp Leu Leu Cys Asn Val Ile Gln Thr Thr Ser
            3540                3545                3550        
Leu His Asp Ile Leu Trp His Phe Val Ala Ser Leu Thr Pro Ala Pro
        3555                3560                3565            
Val Glu Pro Glu Glu Glu Glu Asp Glu Glu Asn Lys Thr Ser Lys Glu
    3570                3575                3580                
Asn Ser Glu Gln Glu Lys Asp Thr Arg Val Cys Glu His Pro Leu Ser
3585                3590                3595                3600
Asp Ile Val Ile Ala Gly Glu Arg Ala His Pro Leu Pro His Thr Phe
                3605                3610                3615    
His Arg Leu Leu Gln Thr Ile Ser Asp Leu Met Met Ser Leu Pro Ser
            3620                3625                3630        
Gly Ser Ser Leu Gln Gln Met Ala Leu Arg Cys Trp Ser Leu Lys Phe
        3635                3640                3645            
Lys Gln Ser Asp His Gln Phe Leu His Gln Ser Asn Val Phe His His
    3650                3655                3660                
Ile Asn Asn Ile Leu Ser Lys Ser Asp Asp Gly Asp Ser Glu Glu Ser
3665                3670                3675                3680
Phe Ser Ile Ser Ile Gln Ser Gly Phe Glu Ala Met Ser Gln Glu Leu
                3685                3690                3695    
Cys Ile Val Met Cys Leu Lys Asp Leu Thr Ser Ile Val Asp Ile Lys
            3700                3705                3710        
Thr Ser Ser Arg Pro Ala Met Ile Gly Ser Leu Thr Asp Gly Ser Thr
        3715                3720                3725            
Glu Thr Phe Trp Glu Ser Gly Asp Glu Asp Lys Asn Lys Thr Lys Asn
    3730                3735                3740                
Ile Thr Ile Asn Cys Val Lys Gly Ile Asn Ala Arg Tyr Val Ser Val
3745                3750                3755                3760
His Val Asp Asn Ser Arg Asp Leu Gly Asn Lys Val Thr Ser Met Thr
                3765                3770                3775    
Phe Leu Thr Gly Lys Ala Val Glu Asp Leu Cys Arg Ile Lys Gln Val
            3780                3785                3790        
Asp Leu Asp Ser Arg His Ile Gly Trp Val Thr Ser Glu Leu Pro Gly
        3795                3800                3805            
Gly Asp Asn His Ile Ile Lys Ile Glu Leu Lys Gly Pro Glu Asn Thr
    3810                3815                3820                
Leu Arg Val Arg Gln Val Lys Val Leu Gly Trp Lys Asp Gly Glu Ser
3825                3830                3835                3840
Thr Lys Ile Ala Gly Gln Ile Ser Ala Ser Val Ala Gln Gln Arg Asn
                3845                3850                3855    
Cys Glu Ala Glu Thr Leu Arg Val Phe Arg Leu Ile Thr Ser Gln Val
            3860                3865                3870        
Phe Gly Lys Leu Ile Ser Gly Asp Ala Glu Pro Thr Pro Glu Gln Glu
        3875                3880                3885            
Glu Lys Ala Leu Leu Ser Ser Pro Glu Gly Glu Glu Lys Val Tyr Asn
    3890                3895                3900                
Ala Thr Ser Asp Ala Asp Leu Lys Glu His Met Val Gly Ile Ile Phe
3905                3910                3915                3920
Ser Arg Ser Lys Leu Thr Asn Leu Gln Lys Gln Val Cys Ala His Ile
                3925                3930                3935    
Val Gln Ala Ile Arg Met Glu Ala Thr Arg Val Arg Glu Glu Trp Glu
            3940                3945                3950        
His Ala Ile Ser Ser Lys Glu Asn Ala Asn Ser Gln Pro Asn Asp Glu
        3955                3960                3965            
Asp Ala Ser Ser Asp Ala Tyr Cys Phe Glu Leu Leu Ser Met Val Leu
    3970                3975                3980                
Ala Leu Ser Gly Ser Asn Val Gly Arg Gln Tyr Leu Ala Gln Gln Leu
3985                3990                3995                4000
Thr Leu Leu Gln Asp Leu Phe Ser Leu Leu His Thr Ala Ser Pro Arg
                4005                4010                4015    
Val Gln Arg Gln Val Thr Ser Leu Leu Arg Arg Val Leu Pro Glu Val
            4020                4025                4030        
Thr Pro Ser Arg Leu Ala Ser Ile Ile Gly Val Lys Ser Leu Pro Pro
        4035                4040                4045            
Ala Asp Ile Ser Asp Ile Ile His Ser Thr Glu Lys Gly Asp Trp Asn
    4050                4055                4060                
Lys Leu Gly Ile Leu Asp Met Phe Leu Gly Cys Ile Ala Lys Ala Leu
4065                4070                4075                4080
Thr Val Gln Leu Lys Ala Lys Gly Thr Thr Ile Thr Gly Thr Ala Gly
                4085                4090                4095    
Thr Thr Val Gly Lys Gly Val Thr Thr Val Thr Leu Pro Met Ile Phe
            4100                4105                4110        
Asn Ser Ser Tyr Leu Arg Arg Gly Glu Ser His Trp Trp Met Lys Gly
        4115                4120                4125            
Ser Thr Pro Thr Gln Ile Ser Glu Ile Ile Ile Lys Leu Ile Lys Asp
    4130                4135                4140                
Met Ala Ala Gly His Leu Ser Glu Ala Trp Ser Arg Val Thr Lys Asn
4145                4150                4155                4160
Ala Ile Ala Glu Thr Ile Ile Ala Leu Thr Lys Met Glu Glu Glu Phe
                4165                4170                4175    
Arg Ser Pro Val Arg Cys Ile Ala Thr Thr Arg Leu Trp Leu Ala Leu
            4180                4185                4190        
Ala Ser Leu Cys Val Leu Asp Gln Asp His Val Asp Arg Leu Ser Ser
        4195                4200                4205            
Gly Arg Trp Met Gly Lys Asp Gly Gln Gln Lys Gln Met Pro Met Cys
    4210                4215                4220                
Asp Asn His Asp Asp Gly Glu Thr Ala Ala Ile Ile Leu Cys Asn Val
4225                4230                4235                4240
Cys Gly Asn Leu Cys Thr Asp Cys Asp Arg Phe Leu His Leu His Arg
                4245                4250                4255    
Arg Thr Lys Thr His Gln Arg Gln Val Phe Lys Glu Glu Glu Glu Ala
            4260                4265                4270        
Ile Lys Val Asp Leu His Glu Gly Cys Gly Arg Thr Lys Leu Phe Trp
        4275                4280                4285            
Leu Met Ala Leu Ala Asp Ser Lys Thr Met Lys Ala Met Val Glu Phe
    4290                4295                4300                
Arg Glu His Thr Gly Lys Pro Thr Thr Ser Ser Ser Glu Ala Cys Arg
4305                4310                4315                4320
Phe Cys Gly Ser Arg Ser Gly Thr Glu Leu Ser Ala Val Gly Ser Val
                4325                4330                4335    
Cys Ser Asp Ala Asp Cys Gln Glu Tyr Ala Lys Ile Ala Cys Ser Lys
            4340                4345                4350        
Thr His Pro Cys Gly His Pro Cys Gly Gly Val Lys Asn Glu Glu His
        4355                4360                4365            
Cys Leu Pro Cys Leu His Gly Cys Asp Lys Ser Ala Thr Ser Leu Lys
    4370                4375                4380                
Gln Asp Ala Asp Asp Met Cys Met Ile Cys Phe Thr Glu Ala Leu Ser
4385                4390                4395                4400
Ala Ala Pro Ala Ile Gln Leu Asp Cys Ser His Ile Phe His Leu Gln
                4405                4410                4415    
Cys Cys Arg Arg Val Leu Glu Asn Arg Trp Leu Gly Pro Arg Ile Thr
            4420                4425                4430        
Phe Gly Phe Ile Ser Cys Pro Ile Cys Lys Asn Lys Ile Asn His Ile
        4435                4440                4445            
Val Leu Lys Asp Leu Leu Asp Pro Ile Lys Glu Leu Tyr Glu Asp Val
    4450                4455                4460                
Arg Arg Lys Ala Leu Met Arg Leu Glu Tyr Glu Gly Leu His Lys Ser
4465                4470                4475                4480
Glu Ala Ile Thr Thr Pro Gly Val Arg Phe Tyr Asn Asp Pro Ala Gly
                4485                4490                4495    
Tyr Ala Met Asn Arg Tyr Ala Tyr Tyr Val Cys Tyr Lys Cys Arg Lys
            4500                4505                4510        
Ala Tyr Phe Gly Gly Glu Ala Arg Cys Asp Ala Glu Ala Gly Arg Gly
        4515                4520                4525            
Asp Asp Tyr Asp Pro Arg Glu Leu Ile Cys Gly Ala Cys Ser Asp Val
    4530                4535                4540                
Ser Arg Ala Gln Met Cys Pro Lys His Gly Thr Asp Phe Leu Glu Tyr
4545                4550                4555                4560
Lys Cys Arg Tyr Cys Cys Ser Val Ala Val Phe Phe Cys Phe Gly Thr
                4565                4570                4575    
Thr His Phe Cys Asn Ala Cys His Asp Asp Phe Gln Arg Met Thr Ser
            4580                4585                4590        
Ile Pro Lys Glu Glu Leu Pro His Cys Pro Ala Gly Pro Lys Gly Lys
        4595                4600                4605            
Gln Leu Glu Gly Thr Glu Cys Pro Leu His Val Val His Pro Pro Thr
    4610                4615                4620                
Gly Glu Glu Phe Ala Leu Gly Cys Gly Val Cys Arg Asn Ala His Thr
4625                4630                4635                4640
Phe
    


<210> 8748
<211> 154
<212> PRT
<213> Homo sapiens

<400> 8748
Met Ala Arg Arg Ala Gly Gly Ala Arg Met Phe Gly Ser Leu Leu Leu
 1               5                  10                  15      
Phe Ala Leu Leu Ala Ala Gly Val Ala Pro Leu Ser Trp Asp Leu Pro
            20                  25                  30          
Glu Pro Arg Ser Arg Ala Ser Lys Ile Arg Val His Ser Arg Gly Asn
        35                  40                  45              
Leu Trp Ala Thr Gly His Phe Met Gly Lys Lys Ser Leu Glu Pro Ser
    50                  55                  60                  
Ser Pro Ser Pro Leu Gly Thr Ala Thr His Thr Ser Leu Arg Asp Gln
65                  70                  75                  80  
Arg Leu Gln Leu Ser His Asp Leu Leu Gly Ile Leu Leu Leu Lys Lys
                85                  90                  95      
Ala Leu Gly Val Ser Leu Ser Arg Pro Ala Pro Gln Ile Gln Glu Ala
            100                 105                 110         
Ala Gly Thr Asn Thr Ala Glu Met Thr Pro Ile Met Gly Gln Thr Gln
        115                 120                 125             
Gln Arg Gly Leu Asp Cys Ala His Pro Gly Lys Val Leu Asn Gly Thr
    130                 135                 140                 
Leu Leu Met Ala Pro Ser Gly Cys Lys Ser
145                 150                 


<210> 8749
<211> 521
<212> PRT
<213> Homo sapiens

<400> 8749
Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser
 1               5                  10                  15      
Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu
            20                  25                  30          
Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly
        35                  40                  45              
Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu
    50                  55                  60                  
Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp
65                  70                  75                  80  
Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser
                85                  90                  95      
Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys
            100                 105                 110         
Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg
        115                 120                 125             
Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser
    130                 135                 140                 
Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn
145                 150                 155                 160 
Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp
                165                 170                 175     
Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe
            180                 185                 190         
Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val
        195                 200                 205             
Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly
    210                 215                 220                 
Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala
225                 230                 235                 240 
Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys
                245                 250                 255     
Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp
            260                 265                 270         
Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr
        275                 280                 285             
His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val
    290                 295                 300                 
Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser
305                 310                 315                 320 
Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg
                325                 330                 335     
Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly
            340                 345                 350         
Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val
        355                 360                 365             
Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser
    370                 375                 380                 
Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe Asn Phe Leu Lys His Ile
385                 390                 395                 400 
Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu
                405                 410                 415     
Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg
            420                 425                 430         
Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu
        435                 440                 445             
Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Gly
    450                 455                 460                 
Arg Gly Ala Gly Pro Ser Arg Ser Ala Asn Ser Gly Ser Leu Lys Glu
465                 470                 475                 480 
Glu Pro Leu Ile Leu Ser Thr Glu Cys Pro Leu Glu Pro Ala Thr Thr
                485                 490                 495     
Leu Arg Gly Pro Leu Ala Phe Pro Ala Gly Ala Gly Gly Ser Gln Val
            500                 505                 510         
Phe Gln Leu Leu Phe Leu Lys Pro Phe
        515                 520     


<210> 8750
<211> 538
<212> PRT
<213> Homo sapiens

<400> 8750
Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser
 1               5                  10                  15      
Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu
            20                  25                  30          
Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly
        35                  40                  45              
Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu
    50                  55                  60                  
Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp
65                  70                  75                  80  
Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser
                85                  90                  95      
Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys
            100                 105                 110         
Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg
        115                 120                 125             
Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser
    130                 135                 140                 
Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn
145                 150                 155                 160 
Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp
                165                 170                 175     
Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe
            180                 185                 190         
Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val
        195                 200                 205             
Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly
    210                 215                 220                 
Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala
225                 230                 235                 240 
Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys
                245                 250                 255     
Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp
            260                 265                 270         
Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr
        275                 280                 285             
His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val
    290                 295                 300                 
Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser
305                 310                 315                 320 
Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg
                325                 330                 335     
Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly
            340                 345                 350         
Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val
        355                 360                 365             
Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser
    370                 375                 380                 
Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe Asn Phe Leu Lys His Ile
385                 390                 395                 400 
Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu
                405                 410                 415     
Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg
            420                 425                 430         
Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu
        435                 440                 445             
Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala
    450                 455                 460                 
Val Glu Leu Val Pro Ala Gly Ala Pro Thr Gln Ala Ala Trp Leu Ala
465                 470                 475                 480 
Ala Leu Ser Asp Arg Glu Thr Arg Leu Gln Glu Val Arg Ser Ala Phe
                485                 490                 495     
Leu Ala Ala Tyr Ser Ser Thr Val Gly Leu Arg Ala Val Ala Pro Ser
            500                 505                 510         
Pro Ser Gly Ala Ile Gly Gly Leu Leu Glu Gln Phe Ala Arg Gly Val
        515                 520                 525             
Gly Leu Arg Ser Ile Ser Ser Asn Ala Leu
    530                 535             


<210> 8751
<211> 650
<212> PRT
<213> Homo sapiens

<400> 8751
Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser
 1               5                  10                  15      
Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu
            20                  25                  30          
Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly
        35                  40                  45              
Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu
    50                  55                  60                  
Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp
65                  70                  75                  80  
Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser
                85                  90                  95      
Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys
            100                 105                 110         
Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg
        115                 120                 125             
Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser
    130                 135                 140                 
Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn
145                 150                 155                 160 
Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp
                165                 170                 175     
Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe
            180                 185                 190         
Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val
        195                 200                 205             
Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly
    210                 215                 220                 
Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala
225                 230                 235                 240 
Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys
                245                 250                 255     
Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp
            260                 265                 270         
Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr
        275                 280                 285             
His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val
    290                 295                 300                 
Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser
305                 310                 315                 320 
Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg
                325                 330                 335     
Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly
            340                 345                 350         
Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val
        355                 360                 365             
Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser
    370                 375                 380                 
Lys Gly Glu Glu Ile Ser Phe Phe Cys Phe Asn Phe Leu Lys His Ile
385                 390                 395                 400 
Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu
                405                 410                 415     
Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg
            420                 425                 430         
Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu
        435                 440                 445             
Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala
    450                 455                 460                 
Val Glu Leu Val Pro Ala Gly Ala Pro Thr Gln Ala Ala Trp Arg Lys
465                 470                 475                 480 
Ser His Ser Ser Ser Pro Gln Ser Val Leu Trp Asn Arg Pro Gln Pro
                485                 490                 495     
Ser Glu Asp Arg Leu Pro Ser Gln Gln Gly Leu Ala Glu Ala Arg Ser
            500                 505                 510         
Ser Ser Ser Ser Ser Ser Asn His Ser Asp Asn Phe Phe Arg Met Gly
        515                 520                 525             
Ser Ser Pro Leu Glu Val Pro Lys Pro Arg Ser Val Asp His Pro Leu
    530                 535                 540                 
Pro Gly Ser Ser Leu Ser Thr Asp Tyr Gly Ser Trp Gln Met Val Thr
545                 550                 555                 560 
Gly Cys Gly Ser Ile Gln Glu Arg Ala Val Leu His Thr Asp Ser Ser
                565                 570                 575     
Leu Pro Phe Ser Phe Pro Asp Glu Leu Pro Asn Ser Cys Leu Leu Ala
            580                 585                 590         
Ala Leu Ser Asp Arg Glu Thr Arg Leu Gln Glu Val Arg Ser Ala Phe
        595                 600                 605             
Leu Ala Ala Tyr Ser Ser Thr Val Gly Leu Arg Ala Val Ala Pro Ser
    610                 615                 620                 
Pro Ser Gly Ala Ile Gly Gly Leu Leu Glu Gln Phe Ala Arg Gly Val
625                 630                 635                 640 
Gly Leu Arg Ser Ile Ser Ser Asn Ala Leu
                645                 650 


<210> 8752
<211> 598
<212> PRT
<213> Homo sapiens

<400> 8752
Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser
 1               5                  10                  15      
Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu
            20                  25                  30          
Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly
        35                  40                  45              
Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu
    50                  55                  60                  
Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp
65                  70                  75                  80  
Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser
                85                  90                  95      
Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys
            100                 105                 110         
Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg
        115                 120                 125             
Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser
    130                 135                 140                 
Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn
145                 150                 155                 160 
Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp
                165                 170                 175     
Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe
            180                 185                 190         
Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val
        195                 200                 205             
Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly
    210                 215                 220                 
Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala
225                 230                 235                 240 
Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys
                245                 250                 255     
Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp
            260                 265                 270         
Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr
        275                 280                 285             
His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val
    290                 295                 300                 
Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser
305                 310                 315                 320 
Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg
                325                 330                 335     
Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly
            340                 345                 350         
Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val
        355                 360                 365             
Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser
    370                 375                 380                 
Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe Asn Phe Leu Lys His Ile
385                 390                 395                 400 
Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu
                405                 410                 415     
Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg
            420                 425                 430         
Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu
        435                 440                 445             
Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala
    450                 455                 460                 
Val Glu Leu Val Pro Ala Gly Ala Pro Thr Gln Ala Ala Trp Arg Lys
465                 470                 475                 480 
Ser His Ser Ser Ser Pro Gln Ser Val Leu Trp Asn Arg Pro Gln Pro
                485                 490                 495     
Ser Glu Asp Arg Leu Pro Ser Gln Gln Gly Leu Ala Glu Ala Arg Ser
            500                 505                 510         
Ser Ser Ser Ser Ser Ser Asn His Ser Asp Asn Phe Phe Arg Met Gly
        515                 520                 525             
Ser Ser Pro Leu Glu Val Pro Lys Pro Arg Leu Ala Ala Leu Ser Asp
    530                 535                 540                 
Arg Glu Thr Arg Leu Gln Glu Val Arg Ser Ala Phe Leu Ala Ala Tyr
545                 550                 555                 560 
Ser Ser Thr Val Gly Leu Arg Ala Val Ala Pro Ser Pro Ser Gly Ala
                565                 570                 575     
Ile Gly Gly Leu Leu Glu Gln Phe Ala Arg Gly Val Gly Leu Arg Ser
            580                 585                 590         
Ile Ser Ser Asn Ala Leu
        595             


<210> 8753
<211> 650
<212> PRT
<213> Homo sapiens

<400> 8753
Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser
 1               5                  10                  15      
Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu
            20                  25                  30          
Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly
        35                  40                  45              
Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu
    50                  55                  60                  
Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp
65                  70                  75                  80  
Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser
                85                  90                  95      
Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys
            100                 105                 110         
Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg
        115                 120                 125             
Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser
    130                 135                 140                 
Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn
145                 150                 155                 160 
Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp
                165                 170                 175     
Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe
            180                 185                 190         
Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val
        195                 200                 205             
Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly
    210                 215                 220                 
Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala
225                 230                 235                 240 
Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys
                245                 250                 255     
Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp
            260                 265                 270         
Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr
        275                 280                 285             
His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val
    290                 295                 300                 
Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser
305                 310                 315                 320 
Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg
                325                 330                 335     
Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly
            340                 345                 350         
Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val
        355                 360                 365             
Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser
    370                 375                 380                 
Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe Asn Phe Leu Lys His Ile
385                 390                 395                 400 
Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu
                405                 410                 415     
Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg
            420                 425                 430         
Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu
        435                 440                 445             
Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala
    450                 455                 460                 
Val Glu Leu Val Pro Ala Gly Ala Pro Thr Gln Ala Ala Trp Arg Lys
465                 470                 475                 480 
Ser His Ser Ser Ser Pro Gln Ser Val Leu Trp Asn Arg Pro Gln Pro
                485                 490                 495     
Ser Glu Asp Arg Leu Pro Ser Gln Gln Gly Leu Ala Glu Ala Arg Ser
            500                 505                 510         
Ser Ser Ser Ser Ser Ser Asn His Ser Asp Asn Phe Phe Arg Met Gly
        515                 520                 525             
Ser Ser Pro Leu Glu Val Pro Lys Pro Arg Ser Val Asp His Pro Leu
    530                 535                 540                 
Pro Gly Ser Ser Leu Ser Thr Asp Tyr Gly Ser Trp Gln Met Val Thr
545                 550                 555                 560 
Gly Cys Gly Ser Ile Gln Glu Arg Ala Val Leu His Thr Asp Ser Ser
                565                 570                 575     
Leu Pro Phe Ser Phe Pro Asp Glu Leu Pro Asn Ser Cys Leu Leu Ala
            580                 585                 590         
Ala Leu Ser Asp Arg Glu Thr Arg Leu Gln Glu Val Arg Ser Ala Phe
        595                 600                 605             
Leu Ala Ala Tyr Ser Ser Thr Val Gly Leu Arg Ala Val Ala Pro Ser
    610                 615                 620                 
Pro Ser Gly Ala Ile Gly Gly Leu Leu Glu Gln Phe Ala Arg Gly Val
625                 630                 635                 640 
Gly Leu Arg Ser Ile Ser Ser Asn Ala Leu
                645                 650 


<210> 8754
<211> 397
<212> PRT
<213> Homo sapiens

<400> 8754
Ser Ser Ser Cys Phe Val Phe Ser Val Ala Ala Cys Thr Asn Thr Ser
 1               5                  10                  15      
Cys Ser Gly His Gly Glu Cys Val Glu Thr Ile Asn Asn Tyr Thr Cys
            20                  25                  30          
Lys Cys Asp Pro Gly Phe Ser Gly Leu Lys Cys Glu Gln Thr Ser Cys
        35                  40                  45              
Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn
    50                  55                  60                  
Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln
65                  70                  75                  80  
Phe Asp Cys Arg Met Pro Met Gly Leu Ser Thr Gly Ile Ile Ser Asp
                85                  90                  95      
Ser Gln Ile Lys Ala Ser Glu Phe Leu Gly Tyr Trp Glu Pro Arg Leu
            100                 105                 110         
Ala Arg Leu Asn Asn Gly Gly Ser Tyr Asn Ala Trp Ser Val Glu Lys
        115                 120                 125             
Leu Ala Ala Glu Phe Ala Ser Lys Pro Trp Ile Gln Val Asp Met Gln
    130                 135                 140                 
Lys Glu Val Ile Ile Thr Gly Ile Gln Thr Gln Gly Ala Lys His Tyr
145                 150                 155                 160 
Leu Lys Ser Cys Tyr Thr Thr Glu Phe Tyr Val Ala Tyr Ser Ser Asn
                165                 170                 175     
Gln Ile Asn Trp Gln Ile Phe Lys Gly Asn Ser Thr Arg Asn Val Met
            180                 185                 190         
Tyr Phe Asn Gly Asn Ser Asp Ala Ser Thr Ile Lys Glu Asn Gln Phe
        195                 200                 205             
Asp Pro Pro Ile Val Ala Arg Tyr Ile Arg Ile Ser Pro Thr Arg Ala
    210                 215                 220                 
Tyr Asn Arg Pro Thr Leu Arg Leu Glu Leu Gln Gly Cys Glu Val Asn
225                 230                 235                 240 
Gly Cys Ser Thr Pro Leu Gly Met Glu Asn Gly Lys Ile Glu Asn Lys
                245                 250                 255     
Gln Ile Thr Ala Ser Ser Phe Lys Lys Ser Trp Trp Gly Asp Tyr Trp
            260                 265                 270         
Glu Pro Phe Arg Ala Arg Leu Asn Ala Gln Gly Arg Val Asn Ala Trp
        275                 280                 285             
Gln Ala Lys Ala Asn Asn Asn Lys Gln Trp Leu Glu Ile Asp Leu Leu
    290                 295                 300                 
Lys Ile Lys Lys Ile Thr Ala Ile Ile Thr Gln Gly Cys Lys Ser Leu
305                 310                 315                 320 
Ser Ser Glu Met Tyr Val Lys Ser Tyr Thr Ile His Tyr Ser Glu Gln
                325                 330                 335     
Gly Val Glu Trp Lys Pro Tyr Arg Leu Lys Ser Ser Met Val Asp Lys
            340                 345                 350         
Ile Phe Glu Gly Asn Thr Asn Thr Lys Gly His Val Lys Asn Phe Phe
        355                 360                 365             
Asn Pro Pro Ile Ile Ser Arg Phe Ile Arg Val Ile Pro Lys Thr Trp
    370                 375                 380                 
Asn Gln Ser Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys
385                 390                 395         


<210> 8755
<211> 867
<212> PRT
<213> Homo sapiens

<400> 8755
Met Asp Asn Pro Gln Ala Leu Pro Leu Phe Leu Leu Leu Ala Ser Leu
 1               5                  10                  15      
Val Gly Ile Leu Thr Leu Arg Ala Ser Ser Gly Leu Gln Gln Thr Asn
            20                  25                  30          
Phe Ser Ser Ala Phe Ser Ser Asp Ser Lys Ser Ser Ser Gln Gly Leu
        35                  40                  45              
Gly Val Glu Val Pro Ser Ile Lys Pro Pro Ser Trp Lys Val Pro Asp
    50                  55                  60                  
Gln Phe Leu Asp Ser Lys Ala Ser Ala Gly Ile Ser Asp Ser Ser Trp
65                  70                  75                  80  
Phe Pro Glu Ala Leu Ser Ser Asn Met Ser Gly Ser Phe Trp Ser Asn
                85                  90                  95      
Val Ser Ala Glu Gly Gln Asp Leu Ser Pro Val Ser Pro Phe Ser Glu
            100                 105                 110         
Thr Pro Gly Ser Glu Val Phe Pro Asp Ile Ser Asp Pro Gln Val Pro
        115                 120                 125             
Ala Lys Asp Pro Lys Pro Ser Phe Thr Val Lys Thr Pro Ala Ser Asn
    130                 135                 140                 
Ile Ser Thr Gln Val Ser His Thr Lys Leu Ser Val Glu Ala Pro Asp
145                 150                 155                 160 
Ser Lys Phe Ser Pro Asp Asp Met Asp Leu Lys Leu Ser Ala Gln Ser
                165                 170                 175     
Pro Glu Ser Lys Phe Ser Ala Glu Thr His Ser Ala Ala Ser Phe Pro
            180                 185                 190         
Gln Gln Val Gly Gly Pro Leu Ala Val Leu Val Gly Thr Thr Ile Arg
        195                 200                 205             
Leu Pro Leu Val Pro Ile Pro Asn Pro Gly Pro Pro Thr Ser Leu Val
    210                 215                 220                 
Val Trp Arg Arg Gly Ser Lys Val Leu Ala Ala Gly Gly Leu Gly Pro
225                 230                 235                 240 
Gly Ala Pro Leu Ile Ser Leu Asp Pro Ala His Arg Asp His Leu Arg
                245                 250                 255     
Phe Asp Gln Ala Arg Gly Val Leu Glu Leu Ala Ser Ala Gln Leu Asp
            260                 265                 270         
Asp Ala Gly Val Tyr Thr Ala Glu Val Ile Arg Ala Gly Val Ser Gln
        275                 280                 285             
Gln Thr His Glu Phe Thr Val Gly Val Tyr Glu Pro Leu Pro Gln Leu
    290                 295                 300                 
Ser Val Gln Pro Lys Ala Pro Glu Thr Glu Glu Gly Ala Ala Glu Leu
305                 310                 315                 320 
Arg Leu Arg Cys Leu Gly Trp Gly Pro Gly Arg Gly Glu Leu Ser Trp
                325                 330                 335     
Ser Arg Asp Gly Arg Ala Leu Glu Ala Ala Glu Ser Glu Gly Ala Glu
            340                 345                 350         
Thr Pro Arg Met Arg Ser Glu Gly Asp Gln Leu Leu Ile Val Arg Pro
        355                 360                 365             
Val Arg Ser Asp His Ala Arg Tyr Thr Cys Arg Val Arg Ser Pro Phe
    370                 375                 380                 
Gly His Arg Glu Ala Ala Ala Asp Val Ser Val Phe Tyr Gly Pro Asp
385                 390                 395                 400 
Pro Pro Thr Ile Thr Val Ser Ser Asp Arg Asp Ala Ala Pro Ala Arg
                405                 410                 415     
Phe Val Thr Ala Gly Ser Asn Val Thr Leu Arg Cys Ala Ala Ala Ser
            420                 425                 430         
Arg Pro Pro Ala Asp Ile Thr Trp Ser Leu Ala Asp Pro Ala Glu Ala
        435                 440                 445             
Ala Val Pro Ala Gly Ser Arg Leu Leu Leu Pro Ala Val Gly Pro Gly
    450                 455                 460                 
His Ala Gly Thr Tyr Ala Cys Leu Ala Ala Asn Pro Arg Thr Gly Arg
465                 470                 475                 480 
Arg Arg Arg Ser Leu Leu Asn Leu Thr Val Ala Asp Leu Pro Pro Gly
                485                 490                 495     
Ala Pro Gln Cys Ser Val Glu Gly Gly Pro Gly Asp Arg Ser Leu Arg
            500                 505                 510         
Phe Arg Cys Ser Trp Pro Gly Gly Ala Pro Ala Ala Ser Leu Gln Phe
        515                 520                 525             
Gln Gly Leu Pro Glu Gly Ile Arg Ala Gly Pro Val Ser Ser Val Leu
    530                 535                 540                 
Leu Ala Ala Val Pro Ala His Pro Arg Leu Ser Gly Val Pro Ile Thr
545                 550                 555                 560 
Cys Leu Ala Arg His Leu Val Ala Thr Arg Thr Cys Thr Val Thr Pro
                565                 570                 575     
Glu Ala Pro Arg Glu Val Leu Leu His Pro Leu Val Ala Glu Thr Arg
            580                 585                 590         
Leu Gly Glu Ala Glu Val Ala Leu Glu Ala Ser Gly Cys Pro Pro Pro
        595                 600                 605             
Ser Arg Ala Ser Trp Ala Arg Glu Gly Arg Pro Leu Ala Pro Gly Gly
    610                 615                 620                 
Gly Ser Arg Leu Arg Leu Ser Gln Asp Gly Arg Lys Leu His Ile Gly
625                 630                 635                 640 
Asn Phe Ser Leu Asp Trp Asp Leu Gly Asn Tyr Ser Val Leu Cys Ser
                645                 650                 655     
Gly Ala Leu Gly Ala Gly Gly Asp Gln Ile Thr Leu Ile Gly Pro Ser
            660                 665                 670         
Ile Ser Ser Trp Arg Leu Gln Arg Ala Arg Asp Ala Ala Val Leu Thr
        675                 680                 685             
Trp Asp Val Glu Arg Gly Ala Leu Ile Ser Ser Phe Glu Ile Gln Ala
    690                 695                 700                 
Trp Pro Asp Gly Pro Ala Leu Gly Arg Thr Ser Thr Tyr Arg Asp Trp
705                 710                 715                 720 
Val Ser Leu Leu Ile Leu Gly Pro Gln Glu Arg Ser Ala Val Val Pro
                725                 730                 735     
Leu Pro Pro Arg Asn Pro Gly Thr Trp Thr Phe Arg Ile Leu Pro Ile
            740                 745                 750         
Leu Gly Gly Gln Pro Gly Thr Pro Ser Gln Ser Arg Val Tyr Arg Ala
        755                 760                 765             
Gly Pro Thr Leu Ser His Gly Ala Ile Ala Gly Ile Val Leu Gly Ser
    770                 775                 780                 
Leu Leu Gly Leu Ala Leu Leu Ala Val Leu Leu Leu Leu Cys Ile Cys
785                 790                 795                 800 
Cys Leu Cys Arg Phe Arg Gly Lys Thr Pro Glu Lys Lys Lys His Pro
                805                 810                 815     
Ser Thr Leu Val Pro Val Val Thr Pro Ser Glu Lys Lys Met His Ser
            820                 825                 830         
Val Thr Pro Val Glu Ile Ser Trp Pro Leu Asp Leu Lys Val Pro Leu
        835                 840                 845             
Glu Asp His Ser Ser Thr Arg Ala Tyr Gln Ala Gln Thr Pro Val Gln
    850                 855                 860                 
Leu Ser Leu
865         


<210> 8756
<211> 320
<212> PRT
<213> Homo sapiens

<400> 8756
Ala Glu Met Asp Lys Gly Arg Glu Arg Met Ala Ala Ala Ala Ala Ala
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Ala Ala Gln Cys Arg Ser Pro Arg Cys Ala
            20                  25                  30          
Ala Glu Arg Arg Gly Phe Arg Arg Glu Leu Asp Ser Trp Arg His Arg
        35                  40                  45              
Leu Met His Cys Val Gly Phe Glu Ser Ile Leu Glu Gly Leu Tyr Gly
    50                  55                  60                  
Pro Arg Leu Arg Arg Asp Leu Ser Leu Phe Glu Asp Cys Glu Pro Glu
65                  70                  75                  80  
Glu Leu Thr Asp Trp Ser Met Asp Glu Lys Cys Ser Phe Cys Asn Leu
                85                  90                  95      
Gln Arg Glu Ala Val Ser Asp Cys Ile Pro Ser Leu Asp Ser Ser Gln
            100                 105                 110         
Ser Thr Pro Thr Glu Glu Leu Ser Ser Gln Gly Gln Ser Asn Thr Asp
        115                 120                 125             
Lys Ile Glu Cys Gln Ala Glu Asn Tyr Leu Asn Ala Leu Phe Arg Lys
    130                 135                 140                 
Lys Asp Leu Pro Gln Asn Cys Asp Pro Asn Ile Pro Leu Val Ala Gln
145                 150                 155                 160 
Glu Leu Met Lys Lys Met Ile Arg Gln Phe Ala Ile Glu Tyr Ile Ser
                165                 170                 175     
Lys Ser Gly Lys Thr Gln Glu Asn Arg Asn Gly Ser Ile Gly Pro Ser
            180                 185                 190         
Ile Val Cys Lys Ser Ile Gln Met Asn Gln Ala Glu Asn Ser Leu Gln
        195                 200                 205             
Glu Glu Gln Glu Gly Pro Leu Asp Leu Thr Val Asn Arg Met Gln Glu
    210                 215                 220                 
Gln Asn Thr Gln Gln Gly Asp Gly Val Leu Asp Leu Ser Thr Lys Lys
225                 230                 235                 240 
Thr Ser Ile Lys Ser Glu Glu Ser Ser Ile Cys Asp Pro Ser Ser Glu
                245                 250                 255     
Asn Ser Val Ala Gly Met Leu Gln Val Lys Thr Asp Glu Lys Leu Asn
            260                 265                 270         
Val Ser Asp Glu Asn Thr Ala Ser Cys Pro Leu Ser Pro Ile Lys Met
        275                 280                 285             
Cys Leu Asn Arg Pro Ile Glu Trp Asn Leu Asn Leu Thr Thr Ala Ser
    290                 295                 300                 
Leu Thr Ser Cys Thr Val His Asn Gln Asn Leu Lys Ser Glu Glu Lys
305                 310                 315                 320 


<210> 8757
<211> 1678
<212> PRT
<213> Homo sapiens

<400> 8757
Met Glu Lys Arg Lys Ser Ala Leu Asn Lys Val Leu Glu Ser Leu Cys
 1               5                  10                  15      
Ile His His Gln Gln Gln Val Leu Ala Met Leu Lys Phe Leu Val Gln
            20                  25                  30          
Glu Gln Asn Ala Ala Ser Leu Cys Cys Cys Asn Thr Ser Cys Val Val
        35                  40                  45              
Ser Ser Glu Ser Gln Lys Pro Leu Ile Glu Asp Asp Leu Cys Gly Leu
    50                  55                  60                  
Phe Cys Ser Cys Glu Tyr Arg Leu Ala Glu Arg Gly Cys Leu Gln Asn
65                  70                  75                  80  
Glu Lys Gln Ser Pro Gly Leu Glu Pro Leu Pro Val Cys Ile Lys Asp
                85                  90                  95      
Leu His Cys Leu Ser Cys Gln Thr Val Thr Val Glu His Val Lys Pro
            100                 105                 110         
Val Val Asn Arg Gly Ile Ala Asp Ser Tyr Asn Ser His Arg Cys Cys
        115                 120                 125             
Ser Gly Leu Leu Pro Asn Ile His Ser Thr Lys Ser Ala Phe Arg Ser
    130                 135                 140                 
Pro Leu Leu Ser Lys Glu Val Cys Asp Leu Ser Val Thr Leu Lys Asp
145                 150                 155                 160 
Ala Cys Arg Ser Arg Ser Pro Ser Pro Pro Pro Leu Ser Pro Ile Glu
                165                 170                 175     
Thr Glu Gly Phe Glu Lys Leu Lys Asp Val Ile Ser Glu Ile Ser Ala
            180                 185                 190         
Leu Glu Asn Asn Lys Leu Glu Ala Asn Ile Asn Gln Pro Pro Ser Leu
        195                 200                 205             
Thr Pro Ala Glu Ile Ser Ser Asn Lys Ser Asp His Gln Asp Lys Ile
    210                 215                 220                 
Leu Lys Thr Lys Lys Ser Ser Asn Ser Tyr Ser Leu Leu Ser Asn Asp
225                 230                 235                 240 
Ser Asn Asn Ser Thr Thr Asn His Glu Lys Gly Glu Thr Ala Val Ile
                245                 250                 255     
Phe Gln Asp Leu Met Asp Arg Ile Asn Glu Lys Leu Lys Ser Ile Glu
            260                 265                 270         
Thr Thr Asp Met Thr Ser Leu Val Lys Leu Ser Ser Ser Asp Tyr Asn
        275                 280                 285             
Thr Tyr Asn Asp Leu Lys Leu Gly Asp Phe Ile Thr Ser Leu Leu His
    290                 295                 300                 
Asn Ala Lys Ala Ser Asp Tyr Ser Phe Met Glu Leu Leu Ser Gln His
305                 310                 315                 320 
Asp Lys Lys Val Glu Asn Lys Ile Ile Gln Thr Arg Phe Arg Lys Arg
                325                 330                 335     
Gln Glu Thr Leu Phe Ala Met Arg Asn Ser Ser Asp Ser Pro Met Phe
            340                 345                 350         
Arg Arg Gln Ser Leu Gln Ile Lys Arg Glu Leu Ala Ser Leu Asp Glu
        355                 360                 365             
Asn Phe Thr Arg Lys Lys Tyr Thr Glu Lys Ser Ser Arg Lys Leu Thr
    370                 375                 380                 
Gln Asn Asn Glu Ile Ser Ser Ser Asp Lys Gly Glu Phe Tyr His Asp
385                 390                 395                 400 
Gln Gly Pro Ser Leu Gln Asn Ser Lys Arg Leu Gln Gly Lys Asn His
                405                 410                 415     
Ala Glu Thr Ser Phe Ser Pro Asn Tyr Ala Leu Gln Ser Leu Gln Leu
            420                 425                 430         
Pro Leu His Ser Ser Glu Thr Asn Leu Ser Phe Asn Glu Phe Ser Glu
        435                 440                 445             
Ser Phe Lys Thr Thr Ser Pro Glu Lys Met Ser Ile Arg Lys Pro Gln
    450                 455                 460                 
Glu Lys Ser Ala Asp Gly Lys Gln Phe Leu Gln Asn Asp Arg Lys Asn
465                 470                 475                 480 
Pro Lys Leu Gly Asn Thr Gln Thr Leu Leu Arg Asn Asp Val Ser Gly
                485                 490                 495     
Leu Leu Ser Arg Thr Lys Arg Asn Ile Val Pro Pro Gly Trp Tyr Ser
            500                 505                 510         
Val Tyr Val Thr Asn Asn Tyr Val Phe Lys Lys Ser Pro Lys Ala Lys
        515                 520                 525             
Lys Val Ser Glu Ser Thr Thr Lys Asn Asp Pro Val Lys Asn Ile His
    530                 535                 540                 
Ile Glu Ser Ser His Asn Ile Asp Leu Asn Lys Ile Ala Met Asn Ser
545                 550                 555                 560 
Asn Leu Gln Val Val Val Lys Arg Leu Glu Asp Thr Ile Ser Ile Ala
                565                 570                 575     
Lys Lys Ser Trp Asn Asn Gln Pro Leu Ser Glu Gly Tyr Lys Ala Ser
            580                 585                 590         
Lys Lys Leu Ile Glu Ile Asp Gly Lys Asp Gln His Ala Asp Arg Asn
        595                 600                 605             
Met Thr Leu Thr Leu Asn Arg Met Thr Cys Lys Glu Gln Ser Leu Ser
    610                 615                 620                 
Lys Ser Val Val Ala Ser Gly Asn Ile Ile Asn Ser His Cys Met Pro
625                 630                 635                 640 
Thr Val Asp Leu Asn Asn Lys Arg Leu Glu Asn Leu Lys Lys Ser Ser
                645                 650                 655     
Ile Leu Asp Met Gly Arg Leu Ile Ser Ser Val Glu Asn Val Pro Ala
            660                 665                 670         
Lys Tyr Glu Gly Thr Glu Ser Ser Ser Val Ser Asn Tyr Ser Ser Pro
        675                 680                 685             
Ile Lys Leu Met Phe Leu Ser Glu Val Lys Ser Ser Glu Gly Val Lys
    690                 695                 700                 
Tyr Thr Leu Thr Ser Val Gly Thr Ser His Ser Asn Val Val Leu Pro
705                 710                 715                 720 
Ser Glu Lys Pro Thr Thr His His Val Thr Glu Glu Lys Thr Glu Thr
                725                 730                 735     
Asn Glu Asp Ile Ser Asn Ala Asn Ser Glu Asn Tyr His Ser Ser His
            740                 745                 750         
Tyr Asp Thr Asp Thr Phe Gln Arg Glu Leu Asn Lys Phe Ser His Ala
        755                 760                 765             
Lys Glu Thr Ala Gly Ser Ser Thr Met Phe Ile Gly Asp Ile Asn Ser
    770                 775                 780                 
Asp Lys Pro Gln Glu Glu Pro Lys Asp Asn Ser Ser Ser Ala Thr Asp
785                 790                 795                 800 
Pro Ser Phe Lys Arg Lys Pro Gly Arg Pro Lys Lys Ile Gly Pro Gln
                805                 810                 815     
Val Val Lys Gln Ile Lys Arg Pro Ile Gly Arg Pro Pro Lys Pro Lys
            820                 825                 830         
Ile Asp Gln Thr Asn Ile Thr Val Cys Gln Asn Glu Pro Phe Ser Ala
        835                 840                 845             
Gly Arg Lys Ser Pro Glu Cys Leu Ile Ser Glu Val Lys Glu Gly Ile
    850                 855                 860                 
Tyr Lys Lys Ser Ile Thr Val Thr Val Ile Tyr Gly Arg Ser Arg Arg
865                 870                 875                 880 
Thr Lys Arg His Val Ser Glu Gly Arg Val Asn Ile Ser Asn Leu Met
                885                 890                 895     
Ser Leu Asn Asn Asn Ala Gly Asp Phe Pro Thr Glu Tyr Asn Ser Pro
            900                 905                 910         
Arg Asn Ile Ser Glu Asp Lys Ile Asp Leu Gly Glu Arg Ile Ser Ala
        915                 920                 925             
Val Ala Ser Leu Thr Thr Glu Ser Glu Ile Leu Gly Ser Gly Phe Glu
    930                 935                 940                 
Tyr Val Arg Pro Ile Lys Asn Lys Ser Val Ile Pro Gln Pro Ser Lys
945                 950                 955                 960 
Asn Ile Ile Arg Pro Asn Gln Lys Pro Leu Ala Ile Ser Arg Lys Pro
                965                 970                 975     
Gly Arg Pro Ala Lys Val Lys Ile Ser Gly Ile Ser Val Thr Ile Asn
            980                 985                 990         
Arg Thr Ser Pro Gln Glu Arg Glu Val Ser Ile Ser Ser Cys Leu Pro
        995                 1000                1005            
Pro Leu Glu Gln Asp Asn Thr Ser Gly Lys Asn Leu Pro Glu Glu Lys
    1010                1015                1020                
Tyr Asp Gln Gln Cys Thr Gln Met Asp Lys Ile Arg His Thr Glu Ala
1025                1030                1035                1040
Asp Ile Phe Lys Asn Gly Ser Lys Arg Met Ile Ala Thr Val Pro Leu
                1045                1050                1055    
Arg His Ser Ile Arg Asp Arg Lys Pro Ser Leu His Phe Leu His Ser
            1060                1065                1070        
Leu Ala Ser Ser Ser Ser Leu Ile Tyr Arg Asn Ala Leu Leu His Lys
        1075                1080                1085            
Ser Tyr Lys Leu His Leu Gln Lys Asn Lys Ser Gln Lys Glu Lys His
    1090                1095                1100                
Arg His Ser Lys Met Lys Ile Ala Tyr Lys Asp Thr Pro Arg Asn Arg
1105                1110                1115                1120
Leu Ser Arg Asn Ala Lys Lys Cys Leu Glu Asp Asn Lys Leu Val Pro
                1125                1130                1135    
Ile Ser Glu Val Ser Leu Asp Pro Ile Ile Ser Ser Asn Pro Leu Leu
            1140                1145                1150        
Arg Trp Trp Ala Thr Ser Ala Ser Asn Asp Ser Leu Leu Glu Glu Leu
        1155                1160                1165            
Asn Asn Arg Phe Glu Gln Ile Thr Asn Ala Trp Val Gln Val Ser Gly
    1170                1175                1180                
Asp Glu Ala Glu Asn Cys Ile His Lys Lys Arg Glu His Ile Glu Asn
1185                1190                1195                1200
Asp His Phe Lys Val Ala Ser Pro Leu Glu Thr Cys Leu Leu Glu Leu
                1205                1210                1215    
Glu Val Ser Pro Val Lys Met Leu Phe Gln Lys Lys Tyr Asp Leu Asn
            1220                1225                1230        
Glu Leu Cys Thr Trp Phe Met Gln Thr Thr Glu Thr Gln Ser Leu Ser
        1235                1240                1245            
Leu Val Arg Lys Ala Asn Ala Arg Asn Pro Leu Glu Val Ile Asn Thr
    1250                1255                1260                
Arg Gly Ile Lys Leu Gly Thr Lys Tyr Ser Asp Phe Asn Ala Ser Pro
1265                1270                1275                1280
Phe Arg Lys His Phe Lys Lys Phe Ala Leu Ser Ser Pro Ser Lys Ser
                1285                1290                1295    
Ala Glu Lys Leu His Ile Leu His Lys Val Ala Asn Ser Pro Leu Leu
            1300                1305                1310        
Asn Val Lys Ser Asn Leu Ala Ile Ala Arg Leu Lys Arg Thr Glu Phe
        1315                1320                1325            
Lys Arg Leu His His Glu Arg Trp Lys Arg Glu Gly Lys Leu His Asn
    1330                1335                1340                
His Gly Thr Val Asp Trp Asn Ser Lys Arg Arg Asn Leu Arg Phe Phe
1345                1350                1355                1360
Cys Gln Asn Gln Phe Leu Asn Lys Thr Glu Gly Glu Thr Asn Ala Asp
                1365                1370                1375    
Ile Pro Leu Gln Gly Lys Ser Ile Val Asp Asn Gln Cys Val Leu Pro
            1380                1385                1390        
Pro Glu Ile Arg Gly Asp Leu Gln Gln Arg Val Val Met Pro Asp Phe
        1395                1400                1405            
Lys Ile His Ala Ser Phe Glu Asn Lys Phe Lys Ser Glu Ala Lys Glu
    1410                1415                1420                
Asn Gly Thr Asn Cys Ser Gln Lys Asp Phe Gln Lys Gly Pro Arg Leu
1425                1430                1435                1440
Glu Asn Val Cys Pro Asn Ser Trp Arg Ser Lys Thr Leu Lys Asp Cys
                1445                1450                1455    
Arg Ile Phe Leu Arg Lys Leu Asn Cys Leu Glu His Arg Asn Thr Phe
            1460                1465                1470        
Lys Leu Asn Thr Ile Ile Tyr Ser Pro Glu Ser Thr Asp Ser Gly Asn
        1475                1480                1485            
Thr His Gln Thr His Met Glu Glu Ser Lys Arg Phe Thr Leu Arg Ser
    1490                1495                1500                
His Ser Ala Arg Gln Asn Ser Phe Lys Lys Gln Ser Lys Glu Ile Glu
1505                1510                1515                1520
Asn Ala Asn Thr Asn Asn Pro Ser Ala Asp Glu Phe Ala Asp His Leu
                1525                1530                1535    
Gly Asn Ser Lys Leu Ser Lys Cys Val Asn Phe Asp Lys Asn Pro Asp
            1540                1545                1550        
Ser Phe Glu Val Leu Ser Asn Leu Asn Lys Arg Lys Arg Pro Pro Trp
        1555                1560                1565            
Lys Ile Thr Glu Met Ser Thr Lys Arg His Lys Arg Gln Ser Cys Asn
    1570                1575                1580                
Ser Gly Gln Met Ala Asn Tyr Phe Ser Lys Ser Leu Ala Ser Ser Glu
1585                1590                1595                1600
Ser Leu Val Asp Lys His Lys Glu Lys Arg Lys Gly Cys Ile Pro Val
                1605                1610                1615    
Pro Gly Ser Met Leu Gln Val Lys Thr Asp Glu Lys Leu Asn Val Ser
            1620                1625                1630        
Asp Glu Asn Thr Ala Ser Cys Pro Leu Ser Pro Ile Lys Met Cys Leu
        1635                1640                1645            
Asn Arg Pro Ile Glu Trp Asn Leu Asn Leu Thr Thr Ala Ser Leu Thr
    1650                1655                1660                
Ser Cys Thr Val His Asn Gln Asn Leu Lys Ser Glu Glu Lys
1665                1670                1675            


<210> 8758
<211> 1030
<212> PRT
<213> Homo sapiens

<400> 8758
Met Ala Ala Ala Ala Ala Val Glu Ala Ala Ala Pro Met Gly Ala Leu
 1               5                  10                  15      
Trp Gly Leu Val His Asp Phe Val Val Gly Gln Gln Glu Gly Pro Ala
            20                  25                  30          
Asp Gln Val Ala Ala Asp Val Lys Ser Gly Asn Tyr Thr Val Leu Gln
        35                  40                  45              
Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Pro Glu Pro Arg Thr
    50                  55                  60                  
Arg Ala Arg Gly Ile Gln Leu Leu Ser Gln Val Leu Leu His Cys His
65                  70                  75                  80  
Thr Leu Leu Leu Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr Glu
                85                  90                  95      
Asn Arg Leu Lys Asp His His Leu Val Ile Pro Ser Val Leu Gln Gly
            100                 105                 110         
Leu Lys Ala Leu Ser Leu Cys Val Ala Leu Pro Pro Gly Leu Ala Val
        115                 120                 125             
Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu Pro
    130                 135                 140                 
Gln Val Asp Arg His Thr Val Tyr Asn Ile Ile Thr Asn Phe Met Arg
145                 150                 155                 160 
Thr Arg Glu Glu Glu Leu Lys Ser Leu Gly Ala Asp Phe Thr Phe Gly
                165                 170                 175     
Phe Ile His Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu Val
            180                 185                 190         
Ala Phe Arg Ile Val His Asp Leu Ile Ser Arg Asp Tyr Ser Leu Gly
        195                 200                 205             
Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro Ile
    210                 215                 220                 
Asp Phe Thr Pro Pro Pro Asn Asp Pro His Gly Ile Gln Arg Glu Asp
225                 230                 235                 240 
Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe Ala
                245                 250                 255     
Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Val Leu
            260                 265                 270         
Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala Val
        275                 280                 285             
Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala Ser
    290                 295                 300                 
Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala Glu
305                 310                 315                 320 
Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Arg Ser Val
                325                 330                 335     
Leu Arg Ala Asp Ala Glu Asp Leu Leu Asp Ser Phe Leu Ser Asn Ile
            340                 345                 350         
Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu Val
        355                 360                 365             
Trp Pro Ser Ala Lys Leu Leu Gln Ala Ala Ala Gly Ala Ser Ala Arg
    370                 375                 380                 
Ala Cys Asp Ser Asp Thr Ser Asn Val Pro Pro Leu Leu Leu Glu Gln
385                 390                 395                 400 
Phe His Lys His Ser Gln Ser Ser Gln Arg Arg Thr Ile Leu Glu Met
                405                 410                 415     
Leu Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp Lys
            420                 425                 430         
Asp Gln Arg Pro Leu Asn Gly Phe Lys Asp Gln Leu Cys Ser Leu Val
        435                 440                 445             
Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly Ile
    450                 455                 460                 
Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Asp Leu Leu Ser Tyr Glu
465                 470                 475                 480 
Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Ser Phe Leu Lys
                485                 490                 495     
Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly Thr
            500                 505                 510         
Leu Ala Ala Leu Tyr Pro Val Ala Phe Ser Ser His Leu Val Pro Lys
        515                 520                 525             
Leu Ala Glu Glu Leu Arg Val Gly Glu Ser Asn Leu Thr Asn Gly Asp
    530                 535                 540                 
Glu Pro Thr Gln Cys Ser Arg His Leu Cys Cys Leu Gln Ala Leu Ser
545                 550                 555                 560 
Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu Leu
                565                 570                 575     
Leu Gln His Leu Trp Gln Val Asn Arg Gly Asn Met Val Ala Gln Ser
            580                 585                 590         
Ser Asp Val Ile Ala Val Cys Gln Ser Leu Arg Gln Met Ala Glu Lys
        595                 600                 605             
Cys Gln Gln Asp Pro Glu Ser Cys Trp Tyr Phe His Gln Thr Ala Ile
    610                 615                 620                 
Pro Cys Leu Leu Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys Glu
625                 630                 635                 640 
Pro Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala Ala
                645                 650                 655     
Met Val Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu Leu
            660                 665                 670         
Ala Ala Gln Ser Val Thr His Ile Val Pro Leu Phe Leu Asp Gly Asn
        675                 680                 685             
Val Ser Phe Leu Pro Glu Asn Ser Phe Pro Ser Arg Phe Gln Pro Phe
    690                 695                 700                 
Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Ile Ala Leu Leu Met Ala
705                 710                 715                 720 
Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn Gln
                725                 730                 735     
Leu Met Arg Glu Phe Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe
            740                 745                 750         
Ser Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His
        755                 760                 765             
Pro Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys
    770                 775                 780                 
Val Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr
785                 790                 795                 800 
Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu
                805                 810                 815     
Ser Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu
            820                 825                 830         
Leu Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys
        835                 840                 845             
Thr Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe
    850                 855                 860                 
Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe
865                 870                 875                 880 
His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser
                885                 890                 895     
His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro
            900                 905                 910         
Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val
        915                 920                 925             
Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala
    930                 935                 940                 
Pro Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu
945                 950                 955                 960 
Asn Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln
                965                 970                 975     
Cys Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr
            980                 985                 990         
Lys Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys
        995                 1000                1005            
Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu
    1010                1015                1020                
Leu Gly Ser Pro Gly Ser
1025                1030


<210> 8759
<211> 932
<212> PRT
<213> Homo sapiens

<400> 8759
Met Ala Ala Ala Ala Ala Val Glu Ala Ala Ala Pro Met Gly Ala Leu
 1               5                  10                  15      
Trp Gly Leu Val His Asp Phe Val Val Gly Gln Gln Glu Gly Pro Ala
            20                  25                  30          
Asp Gln Val Ala Ala Asp Val Lys Ser Gly Asn Tyr Thr Val Leu Gln
        35                  40                  45              
Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Pro Glu Pro Arg Thr
    50                  55                  60                  
Arg Ala Arg Ala Ile Gln Leu Leu Ser Gln Val Leu Leu His Cys His
65                  70                  75                  80  
Thr Leu Leu Leu Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr Glu
                85                  90                  95      
Asn Arg Leu Lys Asp His His Leu Val Ile Pro Ser Val Leu Gln Gly
            100                 105                 110         
Leu Lys Ala Leu Ser Leu Cys Val Ala Leu Pro Pro Gly Leu Ala Val
        115                 120                 125             
Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu Pro
    130                 135                 140                 
Gln Val Asp Arg His Thr Val Tyr Asn Ile Ile Thr Asn Phe Met Arg
145                 150                 155                 160 
Thr Arg Glu Glu Glu Leu Lys Ser Leu Gly Ala Asp Phe Thr Phe Gly
                165                 170                 175     
Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu Val
            180                 185                 190         
Ala Phe Arg Ile Val His Asp Leu Ile Ser Arg Asp Tyr Ser Leu Gly
        195                 200                 205             
Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro Ile
    210                 215                 220                 
Asp Phe Thr Pro Pro Pro Asn Asp Pro His Gly Ile Gln Arg Glu Asp
225                 230                 235                 240 
Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe Ala
                245                 250                 255     
Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Val Leu
            260                 265                 270         
Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala Val
        275                 280                 285             
Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala Ser
    290                 295                 300                 
Ile Arg Arg Glu Ser Ser Gln Arg Arg Thr Ile Leu Glu Met Leu Leu
305                 310                 315                 320 
Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp Lys Asp Gln
                325                 330                 335     
Arg Pro Leu Asn Gly Phe Lys Asp Gln Leu Cys Ser Leu Val Phe Met
            340                 345                 350         
Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly Ile Arg Thr
        355                 360                 365             
Leu Thr Val Leu Gly Ala Gln Pro Asp Leu Leu Ser Tyr Glu Asp Leu
    370                 375                 380                 
Glu Leu Ala Val Gly His Leu Tyr Arg Leu Ser Phe Leu Lys Glu Asp
385                 390                 395                 400 
Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly Thr Leu Ala
                405                 410                 415     
Ala Leu Tyr Pro Val Ala Phe Ser Ser His Leu Val Pro Lys Leu Ala
            420                 425                 430         
Glu Glu Leu Arg Val Gly Glu Ser Asn Leu Thr Asn Gly Asp Glu Pro
        435                 440                 445             
Thr Gln Cys Ser Arg His Leu Cys Cys Leu Gln Ala Leu Ser Ala Val
    450                 455                 460                 
Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu Leu Leu Gln
465                 470                 475                 480 
His Leu Trp Gln Val Asn Arg Gly Asn Met Val Ala Gln Ser Ser Asp
                485                 490                 495     
Val Ile Ala Val Cys Gln Ser Leu Arg Gln Met Ala Glu Lys Cys Gln
            500                 505                 510         
Gln Asp Pro Glu Ser Cys Trp Tyr Phe His Gln Thr Ala Ile Pro Cys
        515                 520                 525             
Leu Leu Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys Glu Pro Ser
    530                 535                 540                 
Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala Ala Met Val
545                 550                 555                 560 
Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu Leu Ala Ala
                565                 570                 575     
Gln Ser Val Thr His Ile Val Pro Leu Phe Leu Asp Gly Asn Val Ser
            580                 585                 590         
Phe Leu Pro Glu Asn Ser Phe Pro Ser Arg Phe Gln Pro Phe Gln Asp
        595                 600                 605             
Gly Ser Ser Gly Gln Arg Arg Leu Ile Ala Leu Leu Met Ala Phe Val
    610                 615                 620                 
Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn Gln Leu Met
625                 630                 635                 640 
Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe Ser Ser
                645                 650                 655     
Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His Pro Ala
            660                 665                 670         
Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys Val Glu
        675                 680                 685             
Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr Leu Leu
    690                 695                 700                 
Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu Ser Ser
705                 710                 715                 720 
Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu Leu Gly
                725                 730                 735     
Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys Thr Asp
            740                 745                 750         
Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe Arg Gln
        755                 760                 765             
Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe His Ala
    770                 775                 780                 
Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser His Val
785                 790                 795                 800 
Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro Thr Leu
                805                 810                 815     
Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val Val Gln
            820                 825                 830         
Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala Pro Gln
        835                 840                 845             
Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu Asn Leu
    850                 855                 860                 
Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln Cys Met
865                 870                 875                 880 
His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr Lys Pro
                885                 890                 895     
Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys Arg Leu
            900                 905                 910         
Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu Leu Gly
        915                 920                 925             
Ser Pro Gly Ser
    930         


<210> 8760
<211> 1030
<212> PRT
<213> Homo sapiens

<400> 8760
Met Ala Ala Ala Ala Ala Val Glu Ala Ala Ala Pro Met Gly Ala Leu
 1               5                  10                  15      
Trp Gly Leu Val His Asp Phe Val Val Gly Gln Gln Glu Gly Pro Ala
            20                  25                  30          
Asp Gln Val Ala Ala Asp Val Lys Ser Gly Asn Tyr Thr Val Leu Gln
        35                  40                  45              
Val Val Glu Ala Leu Gly Ser Ser Leu Glu Asn Pro Glu Pro Arg Thr
    50                  55                  60                  
Arg Ala Arg Gly Ile Gln Leu Leu Ser Gln Val Leu Leu His Cys His
65                  70                  75                  80  
Thr Leu Leu Leu Glu Lys Glu Val Val His Leu Ile Leu Phe Tyr Glu
                85                  90                  95      
Asn Arg Leu Lys Asp His His Leu Val Ile Pro Ser Val Leu Gln Gly
            100                 105                 110         
Leu Lys Ala Leu Ser Leu Cys Val Ala Leu Pro Pro Gly Leu Ala Val
        115                 120                 125             
Ser Val Leu Lys Ala Ile Phe Gln Glu Val His Val Gln Ser Leu Pro
    130                 135                 140                 
Gln Val Asp Arg His Thr Val Tyr Asn Ile Ile Thr Asn Phe Met Arg
145                 150                 155                 160 
Thr Arg Glu Glu Glu Leu Lys Ser Leu Gly Ala Asp Phe Thr Phe Gly
                165                 170                 175     
Phe Ile Gln Val Met Asp Gly Glu Lys Asp Pro Arg Asn Leu Leu Val
            180                 185                 190         
Ala Phe Arg Ile Val His Asp Leu Ile Ser Arg Asp Tyr Ser Leu Gly
        195                 200                 205             
Pro Phe Val Glu Glu Leu Phe Glu Val Thr Ser Cys Tyr Phe Pro Ile
    210                 215                 220                 
Asp Phe Thr Pro Pro Pro Asn Asp Pro His Gly Ile Gln Arg Glu Asp
225                 230                 235                 240 
Leu Ile Leu Ser Leu Arg Ala Val Leu Ala Ser Thr Pro Arg Phe Ala
                245                 250                 255     
Glu Phe Leu Leu Pro Leu Leu Ile Glu Lys Val Asp Ser Glu Val Leu
            260                 265                 270         
Ser Ala Lys Leu Asp Ser Leu Gln Thr Leu Asn Ala Cys Cys Ala Val
        275                 280                 285             
Tyr Gly Gln Lys Glu Leu Lys Asp Phe Leu Pro Ser Leu Trp Ala Ser
    290                 295                 300                 
Ile Arg Arg Glu Val Phe Gln Thr Ala Ser Glu Arg Val Glu Ala Glu
305                 310                 315                 320 
Gly Leu Ala Ala Leu His Ser Leu Thr Ala Cys Leu Ser Arg Ser Val
                325                 330                 335     
Leu Arg Ala Asp Ala Glu Asp Leu Leu Asp Ser Phe Leu Ser Asn Ile
            340                 345                 350         
Leu Gln Asp Cys Arg His His Leu Cys Glu Pro Asp Met Lys Leu Val
        355                 360                 365             
Trp Pro Ser Ala Ser Cys Cys Arg Gln Leu Gln Val His Leu Pro Gly
    370                 375                 380                 
Pro Val Thr Leu Ser Pro Ala Met Tyr Cys Leu Tyr Cys Trp Asn Ser
385                 390                 395                 400 
Ser Thr Ser Thr Val Arg Ala Ala Ser Gly Gly Thr Ile Leu Glu Met
                405                 410                 415     
Leu Leu Gly Phe Leu Lys Leu Gln Gln Lys Trp Ser Tyr Glu Asp Lys
            420                 425                 430         
Asp Gln Arg Pro Leu Asn Gly Phe Lys Asp Gln Leu Cys Ser Leu Val
        435                 440                 445             
Phe Met Ala Leu Thr Asp Pro Ser Thr Gln Leu Gln Leu Val Gly Ile
    450                 455                 460                 
Arg Thr Leu Thr Val Leu Gly Ala Gln Pro Asp Leu Leu Ser Tyr Glu
465                 470                 475                 480 
Asp Leu Glu Leu Ala Val Gly His Leu Tyr Arg Leu Ser Phe Leu Lys
                485                 490                 495     
Glu Asp Ser Gln Ser Cys Arg Val Ala Ala Leu Glu Ala Ser Gly Thr
            500                 505                 510         
Leu Ala Ala Leu Tyr Pro Val Ala Phe Ser Ser His Leu Val Pro Lys
        515                 520                 525             
Leu Ala Glu Glu Leu Arg Val Gly Glu Ser Asn Leu Thr Asn Gly Asp
    530                 535                 540                 
Glu Pro Thr Gln Cys Ser Arg His Leu Cys Cys Leu Gln Ala Leu Ser
545                 550                 555                 560 
Ala Val Ser Thr His Pro Ser Ile Val Lys Glu Thr Leu Pro Leu Leu
                565                 570                 575     
Leu Gln His Leu Trp Gln Val Asn Arg Gly Asn Met Val Ala Gln Ser
            580                 585                 590         
Ser Asp Val Ile Ala Val Cys Gln Ser Leu Arg Gln Met Ala Glu Lys
        595                 600                 605             
Cys Gln Gln Asp Pro Glu Ser Cys Trp Tyr Phe His Gln Thr Ala Ile
    610                 615                 620                 
Pro Cys Leu Leu Ala Leu Ala Val Gln Ala Ser Met Pro Glu Lys Glu
625                 630                 635                 640 
Pro Ser Val Leu Arg Lys Val Leu Leu Glu Asp Glu Val Leu Ala Ala
                645                 650                 655     
Met Val Ser Val Ile Gly Thr Ala Thr Thr His Leu Ser Pro Glu Leu
            660                 665                 670         
Ala Ala Gln Ser Val Thr His Ile Val Pro Leu Phe Leu Asp Gly Asn
        675                 680                 685             
Val Ser Phe Leu Pro Glu Asn Ser Phe Pro Ser Arg Phe Gln Pro Phe
    690                 695                 700                 
Gln Asp Gly Ser Ser Gly Gln Arg Arg Leu Ile Ala Leu Leu Met Ala
705                 710                 715                 720 
Phe Val Cys Ser Leu Pro Arg Asn Val Glu Ile Pro Gln Leu Asn Gln
                725                 730                 735     
Leu Met Arg Glu Leu Leu Glu Leu Ser Cys Cys His Ser Cys Pro Phe
            740                 745                 750         
Ser Ser Thr Ala Ala Ala Lys Cys Phe Ala Gly Leu Leu Asn Lys His
        755                 760                 765             
Pro Ala Gly Gln Gln Leu Asp Glu Phe Leu Gln Leu Ala Val Asp Lys
    770                 775                 780                 
Val Glu Ala Gly Leu Gly Ser Gly Pro Cys Arg Ser Gln Ala Phe Thr
785                 790                 795                 800 
Leu Leu Leu Trp Val Thr Lys Ala Leu Val Leu Arg Tyr His Pro Leu
                805                 810                 815     
Ser Ser Cys Leu Thr Ala Arg Leu Met Gly Leu Leu Ser Asp Pro Glu
            820                 825                 830         
Leu Gly Pro Ala Ala Ala Asp Gly Phe Ser Leu Leu Met Ser Asp Cys
        835                 840                 845             
Thr Asp Val Leu Thr Arg Ala Gly His Ala Glu Val Arg Ile Met Phe
    850                 855                 860                 
Arg Gln Arg Phe Phe Thr Asp Asn Val Pro Ala Leu Val Gln Gly Phe
865                 870                 875                 880 
His Ala Ala Pro Gln Asp Val Lys Pro Asn Tyr Leu Lys Gly Leu Ser
                885                 890                 895     
His Val Leu Asn Arg Leu Pro Lys Pro Val Leu Leu Pro Glu Leu Pro
            900                 905                 910         
Thr Leu Leu Ser Leu Leu Leu Glu Ala Leu Ser Cys Pro Asp Cys Val
        915                 920                 925             
Val Gln Leu Ser Thr Leu Ser Cys Leu Gln Pro Leu Leu Leu Glu Ala
    930                 935                 940                 
Pro Gln Val Met Ser Leu His Val Asp Thr Leu Val Thr Lys Phe Leu
945                 950                 955                 960 
Asn Leu Ser Ser Ser Pro Ser Met Ala Val Arg Ile Ala Ala Leu Gln
                965                 970                 975     
Cys Met His Ala Leu Thr Arg Leu Pro Thr Pro Val Leu Leu Pro Tyr
            980                 985                 990         
Lys Pro Gln Val Ile Arg Ala Leu Ala Lys Pro Leu Asp Asp Lys Lys
        995                 1000                1005            
Arg Leu Val Arg Lys Glu Ala Val Ser Ala Arg Gly Glu Trp Phe Leu
    1010                1015                1020                
Leu Gly Ser Pro Gly Ser
1025                1030


<210> 8761
<211> 480
<212> PRT
<213> Homo sapiens

<400> 8761
Met Arg Val Leu Cys Ala Phe Pro Glu Ala Met Pro Ser Ser Asn Ser
 1               5                  10                  15      
Arg Pro Pro Ala Cys Leu Ala Pro Gly Ala Leu Tyr Leu Ala Leu Leu
            20                  25                  30          
Leu His Leu Ser Leu Ser Ser Gln Ala Gly Asp Arg Arg Pro Leu Pro
        35                  40                  45              
Val Asp Arg Ala Ala Gly Leu Lys Glu Lys Thr Leu Ile Leu Leu Asp
    50                  55                  60                  
Val Ser Thr Lys Asn Pro Val Arg Thr Val Asn Glu Asn Phe Leu Ser
65                  70                  75                  80  
Leu Gln Leu Asp Pro Ser Ile Ile His Asp Gly Trp Leu Asp Phe Leu
                85                  90                  95      
Ser Ser Lys Arg Leu Val Thr Leu Ala Arg Gly Leu Ser Pro Ala Phe
            100                 105                 110         
Leu Arg Phe Gly Gly Lys Arg Thr Asp Phe Leu Gln Phe Gln Asn Leu
        115                 120                 125             
Arg Asn Pro Ala Lys Ser Arg Gly Gly Pro Gly Pro Asp Tyr Tyr Leu
    130                 135                 140                 
Lys Asn Tyr Glu Asp Glu Pro Asn Asn Tyr Arg Thr Met His Gly Arg
145                 150                 155                 160 
Ala Val Asn Gly Ser Gln Leu Gly Lys Asp Tyr Ile Gln Leu Lys Ser
                165                 170                 175     
Leu Leu Gln Pro Ile Arg Ile Tyr Ser Arg Ala Ser Leu Tyr Gly Pro
            180                 185                 190         
Asn Ile Gly Arg Pro Arg Lys Asn Val Ile Ala Leu Leu Asp Gly Phe
        195                 200                 205             
Met Lys Val Ala Gly Ser Thr Val Asp Ala Val Thr Trp Gln His Cys
    210                 215                 220                 
Tyr Ile Asp Gly Arg Val Val Lys Val Met Asp Phe Leu Lys Thr Arg
225                 230                 235                 240 
Leu Leu Asp Thr Leu Ser Asp Gln Ile Arg Lys Ile Gln Lys Val Val
                245                 250                 255     
Asn Thr Tyr Thr Pro Gly Lys Lys Ile Trp Leu Glu Gly Val Val Thr
            260                 265                 270         
Thr Ser Ala Gly Gly Thr Asn Asn Leu Ser Asp Ser Tyr Ala Ala Gly
        275                 280                 285             
Phe Leu Trp Leu Asn Thr Leu Gly Met Leu Ala Asn Gln Gly Ile Asp
    290                 295                 300                 
Val Val Ile Arg His Ser Phe Phe Asp His Gly Tyr Asn His Leu Val
305                 310                 315                 320 
Asp Gln Asn Phe Asn Pro Leu Pro Asp Tyr Trp Leu Ser Leu Leu Tyr
                325                 330                 335     
Lys Arg Leu Ile Gly Pro Lys Val Leu Ala Val His Val Ala Gly Leu
            340                 345                 350         
Gln Arg Lys Pro Arg Pro Gly Arg Val Ile Arg Asp Lys Leu Arg Ile
        355                 360                 365             
Tyr Ala His Cys Thr Asn His His Asn His Asn Tyr Val Arg Gly Ser
    370                 375                 380                 
Ile Thr Leu Phe Ile Ile Asn Leu His Arg Ser Arg Lys Lys Ile Lys
385                 390                 395                 400 
Leu Ala Gly Thr Leu Arg Asp Lys Leu Val His Gln Tyr Leu Leu Gln
                405                 410                 415     
Pro Tyr Gly Gln Glu Gly Leu Lys Ser Lys Ser Val Gln Leu Asn Gly
            420                 425                 430         
Gln Pro Leu Val Met Val Asp Asp Gly Thr Leu Pro Glu Leu Lys Pro
        435                 440                 445             
Arg Pro Leu Arg Ala Gly Arg Thr Leu Val Ile Pro Pro Val Thr Met
    450                 455                 460                 
Gly Phe Phe Val Val Lys Asn Val Asn Ala Leu Ala Cys Arg Tyr Arg
465                 470                 475                 480 


<210> 8762
<211> 242
<212> PRT
<213> Homo sapiens

<400> 8762
Met Leu Ser Cys Phe Arg Leu Leu Ser Arg His Ile Ser Pro Ser Leu
 1               5                  10                  15      
Ala Ser Leu Arg Pro Val Arg Cys Cys Phe Ala Leu Pro Leu Arg Trp
            20                  25                  30          
Ala Pro Gly Arg Pro Leu Asp Pro Arg Gln Ile Ala Pro Arg Arg Pro
        35                  40                  45              
Leu Ala Ala Ala Ala Ser Ser Arg Asp Pro Thr Gly Pro Ala Ala Gly
    50                  55                  60                  
Pro Ser Arg Val Arg Gln Asn Phe His Pro Asp Ser Glu Ala Ala Ile
65                  70                  75                  80  
Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu Ser
                85                  90                  95      
Met Ala Tyr Tyr Phe Ser Arg Asp Asp Val Ala Leu Asn Asn Phe Ser
            100                 105                 110         
Arg Tyr Phe Leu His Gln Ser Arg Glu Glu Thr Glu His Ala Glu Lys
        115                 120                 125             
Leu Met Arg Leu Gln Asn Gln Arg Gly Gly Arg Ile Arg Leu Gln Asp
    130                 135                 140                 
Ile Lys Lys Pro Glu Gln Asp Asp Trp Glu Ser Gly Leu His Ala Met
145                 150                 155                 160 
Glu Cys Ala Leu Leu Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu
                165                 170                 175     
Leu His Ala Leu Ala Ser Asp Lys Gly Asp Pro His Leu Cys Asp Phe
            180                 185                 190         
Leu Glu Thr Tyr Tyr Leu Asn Glu Gln Val Lys Ser Ile Lys Glu Leu
        195                 200                 205             
Gly Asp His Val His Asn Leu Val Lys Met Gly Ala Pro Asp Ala Gly
    210                 215                 220                 
Leu Ala Glu Tyr Leu Phe Asp Thr His Thr Leu Gly Asn Glu Asn Lys
225                 230                 235                 240 
Gln Asn
        


<210> 8763
<211> 425
<212> PRT
<213> Homo sapiens

<400> 8763
Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu
 1               5                  10                  15      
Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser
            20                  25                  30          
Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu
        35                  40                  45              
Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu
    50                  55                  60                  
Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala
65                  70                  75                  80  
His Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln
                85                  90                  95      
Gly Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn
            100                 105                 110         
Arg Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu
        115                 120                 125             
Ile Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu
    130                 135                 140                 
Arg Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala
145                 150                 155                 160 
Glu Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg
                165                 170                 175     
Leu Gly Leu Ser Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg
            180                 185                 190         
Arg Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser
        195                 200                 205             
Val Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu
    210                 215                 220                 
Arg Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile
225                 230                 235                 240 
Lys Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser
                245                 250                 255     
Cys Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys
            260                 265                 270         
Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu
        275                 280                 285             
Gly Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly
    290                 295                 300                 
Ser Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met
305                 310                 315                 320 
Ile Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu
                325                 330                 335     
Thr Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg
            340                 345                 350         
Gly Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly
        355                 360                 365             
Thr Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro
    370                 375                 380                 
Asn Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg
385                 390                 395                 400 
Tyr Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu
                405                 410                 415     
Val Glu Leu Gln Val Ala Pro Leu Gly
            420                 425 


<210> 8764
<211> 582
<212> PRT
<213> Homo sapiens

<400> 8764
Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala
 1               5                  10                  15      
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala
            20                  25                  30          
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp
        35                  40                  45              
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro
    50                  55                  60                  
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val
65                  70                  75                  80  
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly
                85                  90                  95      
Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly
            100                 105                 110         
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr
        115                 120                 125             
Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val
    130                 135                 140                 
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met
145                 150                 155                 160 
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly
                165                 170                 175     
His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp
            180                 185                 190         
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg
        195                 200                 205             
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr
    210                 215                 220                 
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro
225                 230                 235                 240 
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His
                245                 250                 255     
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr
            260                 265                 270         
Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu
        275                 280                 285             
Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala
    290                 295                 300                 
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu
305                 310                 315                 320 
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val
                325                 330                 335     
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn
            340                 345                 350         
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr
        355                 360                 365             
Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro
    370                 375                 380                 
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln
385                 390                 395                 400 
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu
                405                 410                 415     
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys
            420                 425                 430         
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser
        435                 440                 445             
Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu
    450                 455                 460                 
Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala
465                 470                 475                 480 
Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala
                485                 490                 495     
Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala
            500                 505                 510         
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala
        515                 520                 525             
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu
    530                 535                 540                 
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser
545                 550                 555                 560 
Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Lys Glu Val
                565                 570                 575     
Ser Thr Leu Glu Ser His
            580         


<210> 8765
<211> 626
<212> PRT
<213> Homo sapiens

<400> 8765
Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala
 1               5                  10                  15      
Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala
            20                  25                  30          
Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp
        35                  40                  45              
Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro
    50                  55                  60                  
Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val
65                  70                  75                  80  
Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly
                85                  90                  95      
Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly
            100                 105                 110         
Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr
        115                 120                 125             
Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val
    130                 135                 140                 
Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met
145                 150                 155                 160 
Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly
                165                 170                 175     
His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp
            180                 185                 190         
Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg
        195                 200                 205             
Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr
    210                 215                 220                 
Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro
225                 230                 235                 240 
Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His
                245                 250                 255     
Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr
            260                 265                 270         
Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu
        275                 280                 285             
Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala
    290                 295                 300                 
Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu
305                 310                 315                 320 
Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val
                325                 330                 335     
Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn
            340                 345                 350         
Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr
        355                 360                 365             
Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro
    370                 375                 380                 
Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln
385                 390                 395                 400 
Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu
                405                 410                 415     
Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys
            420                 425                 430         
Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser
        435                 440                 445             
Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu
    450                 455                 460                 
Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala
465                 470                 475                 480 
Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala
                485                 490                 495     
Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala
            500                 505                 510         
Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala
        515                 520                 525             
Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu
    530                 535                 540                 
Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser
545                 550                 555                 560 
Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg
                565                 570                 575     
Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu
            580                 585                 590         
Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys
        595                 600                 605             
Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg
    610                 615                 620                 
Val Lys
625     


<210> 8766
<211> 187
<212> PRT
<213> Homo sapiens

<400> 8766
Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Val Ser Gly Ser Gly
 1               5                  10                  15      
Lys Ser Thr Val Gly Ala Leu Leu Ala Ser Glu Leu Gly Trp Lys Phe
            20                  25                  30          
Tyr Asp Ala Asp Asp Tyr His Pro Glu Glu Asn Arg Arg Lys Met Gly
        35                  40                  45              
Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu Cys Asn
    50                  55                  60                  
Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg Val Val
65                  70                  75                  80  
Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu Thr Gln
                85                  90                  95      
Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys Glu Ala
            100                 105                 110         
Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly Ser Phe
        115                 120                 125             
Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe Met Pro
    130                 135                 140                 
Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro Ala Ala
145                 150                 155                 160 
Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser Glu Ile
                165                 170                 175     
Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys
            180                 185         


<210> 8767
<211> 497
<212> PRT
<213> Homo sapiens

<400> 8767
Met Ala Ala Glu Pro Gly His Met Asp Met Gly Ala Glu Ala Leu Pro
 1               5                  10                  15      
Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala Glu Val Thr Thr
            20                  25                  30          
Val Thr Val Ala Asn Val Gly Ala Ala Ala Asp Asn Val Phe Thr Thr
        35                  40                  45              
Ser Val Ala Asn Ala Ala Ser Ile Ser Gly His Val Leu Ser Gly Arg
    50                  55                  60                  
Thr Ala Leu Gln Ile Gly Asp Ser Leu Asn Thr Glu Lys Ala Thr Leu
65                  70                  75                  80  
Ile Val Val His Thr Asp Gly Ser Ile Val Glu Thr Thr Gly Leu Lys
                85                  90                  95      
Gly Pro Ala Ala Pro Leu Thr Pro Gly Pro Gln Ser Pro Pro Thr Pro
            100                 105                 110         
Leu Ala Pro Gly Gln Glu Lys Gly Gly Thr Lys Tyr Asn Trp Asp Pro
        115                 120                 125             
Ser Val Tyr Asp Ser Glu Leu Pro Val Arg Cys Arg Asn Ile Ser Gly
    130                 135                 140                 
Thr Leu Tyr Lys Asn Arg Leu Gly Ser Ala Ala Gly Asp Gly Ala Ser
145                 150                 155                 160 
Ser Arg Gly Arg Thr Gly Thr Cys Pro Thr Glu Phe Glu Ala Met Ala
                165                 170                 175     
Gly Arg Ala Ser Ser Lys Asp Trp Lys Arg Ser Ile Arg Tyr Ala Gly
            180                 185                 190         
Arg Pro Leu Gln Cys Leu Ile Gln Asp Gly Ile Leu Asn Pro His Ala
        195                 200                 205             
Ala Ser Cys Thr Cys Ala Ala Cys Cys Asp Asp Met Thr Leu Ser Gly
    210                 215                 220                 
Pro Val Arg Leu Phe Val Pro Tyr Lys Arg Arg Lys Lys Glu Asn Glu
225                 230                 235                 240 
Leu Pro Thr Thr Pro Val Lys Lys Asp Ser Pro Lys Asn Ile Thr Leu
                245                 250                 255     
Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr Val Thr Pro Ser Gly Gln
            260                 265                 270         
Ile Thr Thr Ser Gly Ala Leu Thr Phe Asp Arg Ala Ser Thr Val Glu
        275                 280                 285             
Ala Thr Ala Val Ile Ser Glu Ser Pro Ala Gln Gly Asp Val Phe Ala
    290                 295                 300                 
Gly Ala Thr Val Gln Glu Ala Ser Val Gln Pro Pro Cys Arg Ala Ser
305                 310                 315                 320 
His Pro Glu Pro His Tyr Pro Gly Tyr Gln Asp Ser Cys Gln Ile Ala
                325                 330                 335     
Pro Phe Pro Glu Ala Ala Leu Pro Thr Ser His Pro Lys Ile Val Leu
            340                 345                 350         
Thr Ser Leu Pro Ala Leu Ala Val Pro Pro Pro Thr Pro Thr Lys Ala
        355                 360                 365             
Ala Pro Pro Ala Leu Val Asn Gly Leu Glu Leu Ser Glu Pro Arg Ser
    370                 375                 380                 
Trp Leu Tyr Leu Glu Glu Met Val Asn Ser Leu Leu Asn Thr Ala Gln
385                 390                 395                 400 
Gln Leu Lys Thr Leu Phe Glu Gln Ala Lys His Ala Ser Thr Tyr Arg
                405                 410                 415     
Glu Ala Ala Thr Asn Gln Ala Lys Ile His Ala Asp Ala Glu Arg Lys
            420                 425                 430         
Glu Gln Ser Cys Val Asn Cys Gly Arg Glu Ala Met Ser Glu Cys Thr
        435                 440                 445             
Gly Cys His Lys Val Asn Tyr Cys Ser Thr Phe Cys Gln Arg Lys Asp
    450                 455                 460                 
Trp Lys Asp His Gln His Ile Cys Gly Gln Ser Ala Ala Val Thr Val
465                 470                 475                 480 
Gln Ala Asp Glu Val His Val Ala Glu Ser Val Met Glu Lys Val Thr
                485                 490                 495     
Val
    


<210> 8768
<211> 497
<212> PRT
<213> Homo sapiens

<400> 8768
Met Ala Ala Glu Pro Gly His Met Asp Met Gly Ala Glu Ala Leu Pro
 1               5                  10                  15      
Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala Glu Val Thr Thr
            20                  25                  30          
Val Thr Val Ala Asn Val Gly Ala Ala Ala Asp Asn Val Phe Thr Thr
        35                  40                  45              
Ser Val Ala Asn Ala Ala Ser Ile Ser Gly His Val Leu Ser Gly Arg
    50                  55                  60                  
Thr Ala Leu Gln Ile Gly Asp Ser Leu Asn Thr Glu Lys Ala Thr Leu
65                  70                  75                  80  
Ile Val Val His Thr Asp Gly Ser Ile Val Glu Thr Thr Gly Leu Lys
                85                  90                  95      
Gly Pro Ala Ala Pro Leu Thr Pro Gly Pro Gln Ser Pro Pro Thr Pro
            100                 105                 110         
Leu Ala Pro Gly Gln Glu Lys Gly Gly Thr Lys Tyr Asn Trp Asp Pro
        115                 120                 125             
Ser Val Tyr Asp Ser Glu Leu Pro Val Arg Cys Arg Asn Ile Ser Gly
    130                 135                 140                 
Thr Leu Tyr Lys Asn Arg Leu Gly Ser Gly Gly Arg Gly Arg Cys Ile
145                 150                 155                 160 
Lys Gln Gly Glu Asn Trp Tyr Ser Pro Thr Glu Phe Glu Ala Met Ala
                165                 170                 175     
Gly Arg Ala Ser Ser Lys Asp Trp Lys Arg Ser Ile Arg Tyr Ala Gly
            180                 185                 190         
Arg Pro Leu Gln Cys Leu Ile Gln Asp Gly Ile Leu Asn Pro His Ala
        195                 200                 205             
Ala Ser Cys Thr Cys Ala Ala Cys Cys Asp Asp Met Thr Leu Ser Gly
    210                 215                 220                 
Pro Val Arg Leu Phe Val Pro Tyr Lys Arg Arg Lys Lys Glu Asn Glu
225                 230                 235                 240 
Leu Pro Thr Thr Pro Val Lys Lys Asp Ser Pro Lys Asn Ile Thr Leu
                245                 250                 255     
Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr Val Thr Pro Ser Gly Gln
            260                 265                 270         
Ile Thr Thr Ser Gly Ala Leu Thr Phe Asp Arg Ala Ser Thr Val Glu
        275                 280                 285             
Ala Thr Ala Val Ile Ser Glu Ser Pro Ala Gln Gly Asp Val Phe Ala
    290                 295                 300                 
Gly Ala Thr Val Gln Glu Ala Ser Val Gln Pro Pro Cys Arg Ala Ser
305                 310                 315                 320 
His Pro Glu Pro His Tyr Pro Gly Tyr Gln Asp Ser Cys Gln Ile Ala
                325                 330                 335     
Pro Phe Pro Glu Ala Ala Leu Pro Thr Ser His Pro Lys Ile Val Leu
            340                 345                 350         
Thr Ser Leu Pro Ala Leu Ala Val Pro Pro Pro Thr Pro Thr Lys Ala
        355                 360                 365             
Ala Pro Pro Ala Leu Val Asn Gly Leu Glu Leu Ser Glu Pro Arg Ser
    370                 375                 380                 
Trp Leu Tyr Leu Glu Glu Met Val Asn Ser Leu Leu Asn Thr Ala Gln
385                 390                 395                 400 
Gln Leu Lys Thr Leu Phe Glu Gln Ala Lys His Ala Ser Thr Tyr Arg
                405                 410                 415     
Glu Ala Ala Thr Asn Gln Ala Lys Ile His Ala Asp Ala Glu Arg Lys
            420                 425                 430         
Glu Gln Ser Cys Val Asn Cys Gly Arg Glu Ala Met Ser Glu Cys Thr
        435                 440                 445             
Gly Cys His Lys Val Asn Tyr Cys Ser Thr Phe Cys Gln Arg Lys Asp
    450                 455                 460                 
Trp Lys Asp His Gln His Ile Cys Gly Gln Ser Ala Ala Val Thr Val
465                 470                 475                 480 
Gln Ala Asp Glu Val His Val Ala Glu Ser Val Met Glu Lys Val Thr
                485                 490                 495     
Val
    


<210> 8769
<211> 551
<212> PRT
<213> Homo sapiens

<400> 8769
Met Glu Asp Ser Asp Ser Ala Ala Lys Gln Leu Gly Leu Ala Asp Ala
 1               5                  10                  15      
Ala Ala Ala Gly Gly Glu Ala Glu Glu Pro Val Leu Ser Arg Asp Glu
            20                  25                  30          
Asp Ser Glu Glu Asp Ala Asp Ser Glu Ala Glu Arg Glu Thr Pro Arg
        35                  40                  45              
Val Thr Ala Val Ala Val Met Ala Ala Glu Pro Gly His Met Asp Met
    50                  55                  60                  
Gly Ala Glu Ala Leu Pro Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala
65                  70                  75                  80  
Phe Ala Glu Val Thr Thr Val Thr Val Ala Asn Val Gly Ala Ala Ala
                85                  90                  95      
Asp Asn Val Phe Thr Thr Ser Val Ala Asn Ala Ala Ser Ile Ser Gly
            100                 105                 110         
His Val Leu Ser Gly Arg Thr Ala Leu Gln Ile Gly Asp Ser Leu Asn
        115                 120                 125             
Thr Glu Lys Ala Thr Leu Ile Val Val His Thr Asp Gly Ser Ile Val
    130                 135                 140                 
Glu Thr Thr Gly Leu Lys Gly Pro Ala Ala Pro Leu Thr Pro Gly Pro
145                 150                 155                 160 
Gln Ser Pro Pro Thr Pro Leu Ala Pro Gly Gln Glu Lys Gly Gly Thr
                165                 170                 175     
Lys Tyr Asn Trp Asp Pro Ser Val Tyr Asp Ser Glu Leu Pro Val Arg
            180                 185                 190         
Cys Arg Asn Ile Ser Gly Thr Leu Tyr Lys Asn Arg Leu Gly Ser Gly
        195                 200                 205             
Gly Arg Gly Arg Cys Ile Lys Gln Gly Glu Asn Trp Tyr Ser Pro Thr
    210                 215                 220                 
Glu Phe Glu Ala Met Ala Gly Arg Ala Ser Ser Lys Asp Trp Lys Arg
225                 230                 235                 240 
Ser Ile Arg Tyr Ala Gly Arg Pro Leu Gln Cys Leu Ile Gln Asp Gly
                245                 250                 255     
Ile Leu Asn Pro His Ala Ala Ser Cys Thr Cys Ala Ala Cys Cys Asp
            260                 265                 270         
Asp Met Thr Leu Ser Gly Pro Val Arg Leu Phe Val Pro Tyr Lys Arg
        275                 280                 285             
Arg Lys Lys Glu Asn Glu Leu Pro Thr Thr Pro Val Lys Lys Asp Ser
    290                 295                 300                 
Pro Lys Asn Ile Thr Leu Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr
305                 310                 315                 320 
Val Thr Pro Ser Gly Gln Ile Thr Thr Ser Gly Ala Leu Thr Phe Asp
                325                 330                 335     
Arg Ala Ser Thr Val Glu Ala Thr Ala Val Ile Ser Glu Ser Pro Ala
            340                 345                 350         
Gln Gly Asp Val Phe Ala Gly Ala Thr Val Gln Glu Ala Ser Val Gln
        355                 360                 365             
Pro Pro Cys Arg Ala Ser His Pro Glu Pro His Tyr Pro Gly Tyr Gln
    370                 375                 380                 
Asp Ser Cys Gln Ile Ala Pro Phe Pro Glu Ala Ala Leu Pro Thr Ser
385                 390                 395                 400 
His Pro Lys Ile Val Leu Thr Ser Leu Pro Ala Leu Ala Val Pro Pro
                405                 410                 415     
Pro Thr Pro Thr Lys Ala Ala Pro Pro Ala Leu Val Asn Gly Leu Glu
            420                 425                 430         
Leu Ser Glu Pro Arg Ser Trp Leu Tyr Leu Glu Glu Met Val Asn Ser
        435                 440                 445             
Leu Leu Asn Thr Ala Gln Gln Leu Lys Thr Leu Phe Glu Gln Ala Lys
    450                 455                 460                 
His Ala Ser Thr Tyr Arg Glu Ala Ala Thr Asn Gln Ala Lys Ile His
465                 470                 475                 480 
Ala Asp Ala Glu Arg Lys Glu Gln Ser Cys Val Asn Cys Gly Arg Glu
                485                 490                 495     
Ala Met Ser Glu Cys Thr Gly Cys His Lys Val Asn Tyr Cys Ser Thr
            500                 505                 510         
Phe Cys Gln Arg Lys Asp Trp Lys Asp His Gln His Ile Cys Gly Gln
        515                 520                 525             
Ser Ala Ala Val Thr Val Gln Ala Asp Glu Val His Val Ala Glu Ser
    530                 535                 540                 
Val Met Glu Lys Val Thr Val
545                 550     


<210> 8770
<211> 576
<212> PRT
<213> Homo sapiens

<400> 8770
Met Glu Asp Ser Asp Ser Ala Ala Lys Gln Leu Gly Leu Ala Glu Ala
 1               5                  10                  15      
Ala Ala Val Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala
            20                  25                  30          
Ala Gly Gly Glu Ala Glu Glu Pro Val Leu Ser Arg Asp Glu Asp Ser
        35                  40                  45              
Glu Glu Asp Ala Asp Ser Glu Ala Glu Arg Glu Thr Pro Arg Val Thr
    50                  55                  60                  
Ala Val Ala Val Met Ala Ala Glu Pro Gly His Met Asp Met Gly Ala
65                  70                  75                  80  
Glu Ala Leu Pro Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala
                85                  90                  95      
Gly Lys Cys Ala Arg Arg Pro Leu Ala Ser Ser Glu Val Thr Thr Val
            100                 105                 110         
Thr Val Ala Asn Val Gly Ala Ala Ala Asp Asn Val Phe Thr Thr Ser
        115                 120                 125             
Val Ala Asn Ala Ala Ser Ile Ser Gly His Val Leu Ser Gly Arg Thr
    130                 135                 140                 
Ala Leu Gln Ile Gly Asp Ser Leu Asn Thr Glu Lys Ala Thr Leu Ile
145                 150                 155                 160 
Val Val His Thr Asp Gly Ser Ile Val Glu Thr Thr Gly Leu Lys Gly
                165                 170                 175     
Pro Ala Ala Pro Leu Thr Pro Gly Pro Gln Ser Pro Pro Thr Pro Leu
            180                 185                 190         
Ala Pro Gly Gln Glu Lys Gly Gly Thr Lys Tyr Asn Trp Asp Pro Ser
        195                 200                 205             
Val Tyr Asp Ser Glu Leu Pro Val Arg Cys Arg Asn Ile Ser Gly Thr
    210                 215                 220                 
Leu Tyr Lys Asn Arg Leu Gly Ser Gly Gly Arg Gly Arg Cys Ile Lys
225                 230                 235                 240 
Gln Gly Glu Asn Trp Tyr Ser Pro Thr Glu Phe Glu Ala Met Ala Gly
                245                 250                 255     
Arg Ala Ser Ser Lys Asp Trp Lys Arg Ser Ile Arg Tyr Ala Gly Arg
            260                 265                 270         
Pro Leu Gln Cys Leu Ile Gln Asp Gly Ile Leu Asn Pro His Ala Ala
        275                 280                 285             
Ser Cys Thr Cys Ala Ala Cys Cys Asp Asp Met Thr Leu Ser Gly Pro
    290                 295                 300                 
Val Arg Leu Phe Val Pro Tyr Lys Arg Arg Lys Lys Glu Asn Glu Leu
305                 310                 315                 320 
Pro Thr Thr Pro Val Lys Lys Asp Ser Pro Lys Asn Ile Thr Leu Leu
                325                 330                 335     
Pro Ala Thr Ala Ala Thr Thr Phe Thr Val Thr Pro Ser Gly Gln Ile
            340                 345                 350         
Thr Thr Ser Gly Ala Leu Thr Phe Asp Arg Ala Ser Thr Val Glu Ala
        355                 360                 365             
Thr Ala Val Ile Ser Glu Ser Pro Ala Gln Gly Asp Val Phe Ala Gly
    370                 375                 380                 
Ala Thr Val Gln Glu Ala Ser Val Gln Pro Pro Cys Arg Ala Ser His
385                 390                 395                 400 
Pro Glu Pro His Tyr Pro Gly Tyr Gln Asp Ser Cys Gln Ile Ala Pro
                405                 410                 415     
Phe Pro Glu Ala Ala Leu Pro Thr Ser His Pro Lys Ile Val Leu Thr
            420                 425                 430         
Ser Leu Pro Ala Leu Ala Val Pro Pro Pro Thr Pro Thr Lys Thr Ala
        435                 440                 445             
Pro Pro Ala Leu Val Asn Gly Leu Glu Leu Ser Glu Pro Arg Ser Trp
    450                 455                 460                 
Leu Tyr Leu Glu Glu Met Val Asn Ser Leu Leu Asn Thr Ala Gln Gln
465                 470                 475                 480 
Leu Lys Thr Leu Phe Glu Gln Ala Lys His Ala Ser Thr Tyr Arg Glu
                485                 490                 495     
Ala Ala Thr Asn Gln Ala Lys Ile His Ala Asp Ala Glu Arg Lys Glu
            500                 505                 510         
Gln Ser Cys Val Asn Cys Gly Arg Glu Ala Met Ser Glu Cys Thr Gly
        515                 520                 525             
Cys His Lys Val Asn Tyr Cys Ser Thr Phe Cys Gln Arg Lys Asp Trp
    530                 535                 540                 
Lys Asp His Gln His Ile Cys Gly Gln Ser Ala Ala Val Thr Val Gln
545                 550                 555                 560 
Ala Asp Glu Val His Val Ala Glu Ser Val Met Glu Lys Val Thr Val
                565                 570                 575     


<210> 8771
<211> 158
<212> PRT
<213> Homo sapiens

<400> 8771
Met Leu Leu Phe Ala Leu Leu Leu Ala Met Glu Leu Pro Leu Val Ala
 1               5                  10                  15      
Ala Ser Ala Thr Met Arg Ala Gln Trp Thr Tyr Ser Leu Arg Cys His
            20                  25                  30          
Asp Cys Ala Val Ile Asn Asp Phe Asn Cys Pro Asn Ile Arg Val Cys
        35                  40                  45              
Pro Tyr His Ile Arg Arg Cys Met Thr Ile Ser Ile Arg Ile Asn Ser
    50                  55                  60                  
Arg Glu Leu Leu Val Tyr Lys Asn Cys Thr Asn Asn Cys Thr Phe Val
65                  70                  75                  80  
Tyr Ala Ala Glu Gln Pro Pro Glu Ala Pro Gly Lys Ile Phe Lys Thr
                85                  90                  95      
Asn Ser Phe Tyr Trp Val Cys Cys Cys Asn Ser Met Val Cys Asn Ala
            100                 105                 110         
Gly Gly Pro Thr Asn Leu Glu Arg Asp Met Leu Pro Asp Glu Val Thr
        115                 120                 125             
Glu Glu Glu Leu Pro Glu Gly Thr Val Arg Leu Gly Val Ser Lys Leu
    130                 135                 140                 
Leu Leu Ser Phe Ala Ser Ile Ile Val Ser Asn Ile Leu Pro
145                 150                 155             


<210> 8772
<211> 341
<212> PRT
<213> Homo sapiens

<400> 8772
Met Gly Arg Arg Cys Cys Arg Arg Arg Val Leu Ala Ala Ala Cys Leu
 1               5                  10                  15      
Gly Ala Ala Leu Leu Leu Leu Cys Ala Ala Pro Arg Ser Leu Arg Pro
            20                  25                  30          
Ala Phe Gly Asn Arg Ala Leu Gly Ser Ser Trp Leu Gly Gly Glu Lys
        35                  40                  45              
Arg Ser Pro Leu Gln Lys Leu Tyr Asp Leu Asp Gln Asp Pro Arg Ser
    50                  55                  60                  
Thr Leu Ala Lys Val His Arg Gln Arg Arg Asp Leu Leu Asn Ser Ala
65                  70                  75                  80  
Cys Ser Arg His Ser Arg Arg Gln Arg Leu Leu Gln Pro Glu Asp Leu
                85                  90                  95      
Arg His Val Leu Val Asp Asp Ala His Gly Leu Leu Tyr Cys Tyr Val
            100                 105                 110         
Pro Lys Val Ala Cys Thr Asn Trp Lys Arg Val Leu Leu Ala Leu Ser
        115                 120                 125             
Gly Gln Ala Arg Gly Asp Pro Arg Ala Ile Ser Ala Gln Glu Ala His
    130                 135                 140                 
Ala Pro Gly Arg Leu Pro Ser Leu Ala Asp Phe Ser Pro Ala Glu Ile
145                 150                 155                 160 
Asn Arg Arg Leu Arg Ala Tyr Leu Ala Phe Leu Phe Val Arg Glu Pro
                165                 170                 175     
Phe Glu Arg Leu Ala Ser Ala Tyr Arg Asn Lys Leu Ala Arg Pro Tyr
            180                 185                 190         
Ser Ala Ala Phe Gln Arg Arg Tyr Gly Ala Arg Ile Val Gln Arg Leu
        195                 200                 205             
Arg Pro Arg Ala Leu Pro Asp Ala Arg Ala Arg Gly His Asp Val Arg
    210                 215                 220                 
Phe Ala Glu Phe Leu Ala Tyr Leu Leu Asp Pro Arg Thr Arg Arg Glu
225                 230                 235                 240 
Glu Pro Phe Asn Glu His Trp Glu Arg Ala His Ala Leu Cys His Pro
                245                 250                 255     
Cys Arg Leu Arg Tyr Asp Val Val Gly Lys Phe Glu Thr Leu Ala Glu
            260                 265                 270         
Asp Ala Ala Phe Val Leu Gly Leu Ala Gly Ala Ser Asp Leu Ser Phe
        275                 280                 285             
Pro Gly Pro Pro Arg Pro Arg Gly Ala Ala Ala Ser Arg Asp Leu Ala
    290                 295                 300                 
Ala Arg Leu Phe Arg Asp Ile Ser Pro Phe Tyr Gln Arg Arg Leu Phe
305                 310                 315                 320 
Asp Leu Tyr Lys Met Asp Phe Leu Leu Phe Asn Tyr Ser Ala Pro Ser
                325                 330                 335     
Tyr Leu Arg Leu Leu
            340     


<210> 8773
<211> 427
<212> PRT
<213> Homo sapiens

<400> 8773
Met Pro Arg Ser Ser Gln Phe Lys Arg Ile Leu Asn Arg Glu Leu Thr
 1               5                  10                  15      
His Leu Ser Glu Thr Ser Arg Ser Gly Asn Gln Val Ser Glu Tyr Ile
            20                  25                  30          
Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu Val Glu Leu Pro Lys Val
        35                  40                  45              
Thr Ala Glu Glu Ala Pro Gln Pro Met Ser Arg Ile Ser Gly Leu His
    50                  55                  60                  
Gly Leu Cys His Ser Ala Ser Leu Ser Ser Ala Thr Val Pro Arg Phe
65                  70                  75                  80  
Gly Val Gln Thr Asp Gln Glu Glu Gln Leu Ala Lys Glu Leu Glu Asp
                85                  90                  95      
Thr Asn Lys Trp Gly Leu Asp Val Phe Lys Val Ala Glu Leu Ser Gly
            100                 105                 110         
Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser Ile Phe Gln Ala Val Phe
        115                 120                 125             
Thr Asp Leu Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp
    130                 135                 140                 
Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser
145                 150                 155                 160 
Glu Leu Ala Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His
                165                 170                 175     
Leu Ala Val Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe
            180                 185                 190         
Gln Asn Leu Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile
        195                 200                 205             
Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala
    210                 215                 220                 
Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val
225                 230                 235                 240 
Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu
                245                 250                 255     
Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr
            260                 265                 270         
Arg Gln Trp Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp
        275                 280                 285             
Arg Glu Arg Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His
    290                 295                 300                 
Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala
305                 310                 315                 320 
His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln
                325                 330                 335     
Asp Leu Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys
            340                 345                 350         
Ile Pro Arg Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro
        355                 360                 365             
Asp Arg Phe Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp
    370                 375                 380                 
Glu Glu Glu Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala
385                 390                 395                 400 
Leu Glu Leu Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp
                405                 410                 415     
Pro Gly Asp Leu Pro Leu Asp Asn Gln Arg Thr
            420                 425         


<210> 8774
<211> 680
<212> PRT
<213> Homo sapiens

<400> 8774
Met Gln Gly Pro Pro Ala Pro Ala Pro Val Pro Gly Pro Gly Ser Pro
 1               5                  10                  15      
Arg Gly Ser Pro Arg Gly Ser Pro Gly Leu Phe Arg Lys Leu Leu Val
            20                  25                  30          
Asn Gln Ser Ile Arg Leu Gln Arg Arg Phe Thr Val Ala His Pro Leu
        35                  40                  45              
Cys Phe Asp Leu Glu Asn Gly Leu Ser Cys Gly Arg Arg Ala Leu Asp
    50                  55                  60                  
Pro Gln Ser Ser Pro Gly Leu Gly Arg Ile Met Gln Ala Pro Val Pro
65                  70                  75                  80  
His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr
                85                  90                  95      
Glu Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Val Ala Ser Asp
            100                 105                 110         
Leu His Gly Glu Asp Met Ile Val Thr Pro Phe Ala Gln Val Leu Ala
        115                 120                 125             
Ser Leu Arg Thr Val Arg Ser Asn Val Ala Ala Leu Ala Arg Gln Gln
    130                 135                 140                 
Cys Leu Gly Ala Ala Lys Gln Gly Pro Val Gly Asn Pro Ser Ser Ser
145                 150                 155                 160 
Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly Gln Lys Leu Ala Leu Glu
                165                 170                 175     
Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln
            180                 185                 190         
Thr Arg His Ser Val Gly Glu Met Ala Ser Asn Lys Phe Lys Arg Ile
        195                 200                 205             
Leu Asn Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg Ser Gly Asn
    210                 215                 220                 
Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu
225                 230                 235                 240 
Val Glu Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln Pro Met Ser
                245                 250                 255     
Arg Ile Ser Gly Leu His Gly Leu Cys His Ser Ala Ser Leu Ser Ser
            260                 265                 270         
Ala Thr Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu Glu Gln Leu
        275                 280                 285             
Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp Val Phe Lys
    290                 295                 300                 
Val Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser
305                 310                 315                 320 
Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile Pro Ala Asp
                325                 330                 335     
Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr His Ala Asn
            340                 345                 350         
Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln Ser Thr
        355                 360                 365             
His Val Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu
    370                 375                 380                 
Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp Val Asp His
385                 390                 395                 400 
Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala
                405                 410                 415     
Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His Leu Ala Val
            420                 425                 430         
Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu
        435                 440                 445             
Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile Asp Met Val
    450                 455                 460                 
Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys
465                 470                 475                 480 
Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val Leu Leu Leu
                485                 490                 495     
Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu Val His Cys
            500                 505                 510         
Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr Arg Gln Trp
        515                 520                 525             
Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg
    530                 535                 540                 
Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser
545                 550                 555                 560 
Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala His Pro Leu
                565                 570                 575     
Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Leu Leu
            580                 585                 590         
Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys Ile Pro Arg
        595                 600                 605             
Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro Asp Arg Phe
    610                 615                 620                 
Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp Glu Glu Glu
625                 630                 635                 640 
Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala Leu Glu Leu
                645                 650                 655     
Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp Pro Gly Asp
            660                 665                 670         
Leu Pro Leu Asp Asn Gln Arg Thr
        675                 680 


<210> 8775
<211> 712
<212> PRT
<213> Homo sapiens

<400> 8775
Met Glu Asn Leu Gly Val Gly Glu Gly Ala Glu Ala Cys Ser Arg Leu
 1               5                  10                  15      
Ser Arg Ser Arg Gly Arg His Ser Met Thr Arg Ala Pro Lys His Leu
            20                  25                  30          
Trp Arg Gln Pro Arg Arg Pro Ile Arg Ile Gln Gln Arg Phe Tyr Ser
        35                  40                  45              
Asp Pro Asp Lys Ser Ala Gly Cys Arg Glu Arg Asp Leu Ser Pro Arg
    50                  55                  60                  
Pro Glu Leu Arg Lys Ser Arg Leu Ser Trp Pro Val Ser Ser Cys Arg
65                  70                  75                  80  
Arg Phe Asp Leu Glu Asn Gly Leu Ser Cys Gly Arg Arg Ala Leu Asp
                85                  90                  95      
Pro Gln Ser Ser Pro Gly Leu Gly Arg Ile Met Gln Ala Pro Val Pro
            100                 105                 110         
His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr
        115                 120                 125             
Glu Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Val Ala Ser Asp
    130                 135                 140                 
Leu His Gly Glu Asp Met Ile Val Thr Pro Phe Ala Gln Val Leu Ala
145                 150                 155                 160 
Ser Leu Arg Thr Val Arg Ser Asn Val Ala Ala Leu Ala Arg Gln Gln
                165                 170                 175     
Cys Leu Gly Ala Ala Lys Gln Gly Pro Val Gly Asn Pro Ser Ser Ser
            180                 185                 190         
Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly Gln Lys Leu Ala Leu Glu
        195                 200                 205             
Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln
    210                 215                 220                 
Thr Arg His Ser Val Gly Glu Met Ala Ser Asn Lys Phe Lys Arg Ile
225                 230                 235                 240 
Leu Asn Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg Ser Gly Asn
                245                 250                 255     
Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu
            260                 265                 270         
Val Glu Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln Pro Met Ser
        275                 280                 285             
Arg Ile Ser Gly Leu His Gly Leu Cys His Ser Ala Ser Leu Ser Ser
    290                 295                 300                 
Ala Thr Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu Glu Gln Leu
305                 310                 315                 320 
Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp Val Phe Lys
                325                 330                 335     
Val Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser
            340                 345                 350         
Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile Pro Ala Asp
        355                 360                 365             
Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr His Ala Asn
    370                 375                 380                 
Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln Ser Thr
385                 390                 395                 400 
His Val Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu
                405                 410                 415     
Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp Val Asp His
            420                 425                 430         
Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala
        435                 440                 445             
Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His Leu Ala Val
    450                 455                 460                 
Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu
465                 470                 475                 480 
Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile Asp Met Val
                485                 490                 495     
Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys
            500                 505                 510         
Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val Leu Leu Leu
        515                 520                 525             
Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu Val His Cys
    530                 535                 540                 
Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr Arg Gln Trp
545                 550                 555                 560 
Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg
                565                 570                 575     
Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser
            580                 585                 590         
Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala His Pro Leu
        595                 600                 605             
Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Leu Leu
    610                 615                 620                 
Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys Ile Pro Arg
625                 630                 635                 640 
Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro Asp Arg Phe
                645                 650                 655     
Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp Glu Glu Glu
            660                 665                 670         
Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala Leu Glu Leu
        675                 680                 685             
Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp Pro Gly Asp
    690                 695                 700                 
Leu Pro Leu Asp Asn Gln Arg Thr
705                 710         


<210> 8776
<211> 795
<212> PRT
<213> Homo sapiens

<400> 8776
Gly Leu Arg Asp Arg Glu Lys Thr Ala Trp Ser Gln Ile Ala Pro Ser
 1               5                  10                  15      
Gly His Arg Gln Leu Leu Gly Val Gly Pro Thr Leu Ser Pro Ser Ser
            20                  25                  30          
Thr Phe Tyr Arg Phe Ser Thr Ser Gly Ala Asp Ser Ser Ser Leu Ser
        35                  40                  45              
Pro Pro Leu Pro Ala Leu Gly Arg Thr Arg Glu Gln Thr Leu Leu Gly
    50                  55                  60                  
Ala Arg Ser Arg Gly Arg Val Leu Leu Pro Ala Ile Pro Asp Pro Phe
65                  70                  75                  80  
Leu Trp Arg Met Glu Asn Leu Gly Val Gly Glu Gly Ala Glu Ala Cys
                85                  90                  95      
Ser Arg Leu Ser Arg Ser Arg Gly Arg His Ser Met Thr Arg Ala Pro
            100                 105                 110         
Lys His Leu Trp Arg Gln Pro Arg Arg Pro Ile Arg Ile Gln Gln Arg
        115                 120                 125             
Phe Tyr Ser Asp Pro Asp Lys Ser Ala Gly Cys Arg Glu Arg Asp Leu
    130                 135                 140                 
Ser Pro Arg Pro Glu Leu Arg Lys Ser Arg Leu Ser Trp Pro Val Ser
145                 150                 155                 160 
Ser Cys Arg Arg Phe Asp Leu Glu Asn Gly Leu Ser Cys Gly Arg Arg
                165                 170                 175     
Ala Leu Asp Pro Gln Ser Ser Pro Gly Leu Gly Arg Ile Met Gln Ala
            180                 185                 190         
Pro Val Pro His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp
        195                 200                 205             
Ser Asp Tyr Glu Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Val
    210                 215                 220                 
Ala Ser Asp Leu His Gly Glu Asp Met Ile Val Thr Pro Phe Ala Gln
225                 230                 235                 240 
Val Leu Ala Ser Leu Arg Thr Val Arg Ser Asn Val Ala Ala Leu Ala
                245                 250                 255     
Arg Gln Gln Cys Leu Gly Ala Ala Lys Gln Gly Pro Val Gly Asn Pro
            260                 265                 270         
Ser Ser Ser Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly Gln Lys Leu
        275                 280                 285             
Ala Leu Glu Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu
    290                 295                 300                 
Thr Leu Gln Thr Arg His Ser Val Gly Glu Met Ala Ser Asn Lys Phe
305                 310                 315                 320 
Lys Arg Ile Leu Asn Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg
                325                 330                 335     
Ser Gly Asn Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln
            340                 345                 350         
Gln Thr Glu Val Glu Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln
        355                 360                 365             
Pro Met Ser Arg Ile Ser Gly Leu His Gly Leu Cys His Ser Ala Ser
    370                 375                 380                 
Leu Ser Ser Ala Thr Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu
385                 390                 395                 400 
Glu Gln Leu Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp
                405                 410                 415     
Val Phe Lys Val Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile
            420                 425                 430         
Ile Phe Ser Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile
        435                 440                 445             
Pro Ala Asp Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr
    450                 455                 460                 
His Ala Asn Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala
465                 470                 475                 480 
Gln Ser Thr His Val Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe
                485                 490                 495     
Thr Asp Leu Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp
            500                 505                 510         
Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser
        515                 520                 525             
Glu Leu Ala Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His
    530                 535                 540                 
Leu Ala Val Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe
545                 550                 555                 560 
Gln Asn Leu Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile
                565                 570                 575     
Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala
            580                 585                 590         
Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val
        595                 600                 605             
Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu
    610                 615                 620                 
Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr
625                 630                 635                 640 
Arg Gln Trp Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp
                645                 650                 655     
Arg Glu Arg Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His
            660                 665                 670         
Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala
        675                 680                 685             
His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln
    690                 695                 700                 
Asp Leu Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys
705                 710                 715                 720 
Ile Pro Arg Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro
                725                 730                 735     
Asp Arg Phe Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp
            740                 745                 750         
Glu Glu Glu Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala
        755                 760                 765             
Leu Glu Leu Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp
    770                 775                 780                 
Pro Gly Asp Leu Pro Leu Asp Asn Gln Arg Thr
785                 790                 795 


<210> 8777
<211> 518
<212> PRT
<213> Homo sapiens

<400> 8777
Pro Leu Arg Ile Arg Pro Leu Leu Pro Thr Ala Tyr His Leu Leu Pro
 1               5                  10                  15      
Thr Gly Pro Gly Gln Ser Ala Asp Arg Ser Glu Gln Arg Gly Gly Pro
            20                  25                  30          
Cys Pro Pro Ala Met Pro Arg Ser Ser Gln Phe Lys Arg Ile Leu Asn
        35                  40                  45              
Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg Ser Gly Asn Gln Val
    50                  55                  60                  
Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu Val Glu
65                  70                  75                  80  
Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln Pro Met Ser Arg Ile
                85                  90                  95      
Ser Gly Leu His Gly Leu Cys His Ser Ala Ser Leu Ser Ser Ala Thr
            100                 105                 110         
Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu Glu Gln Leu Ala Lys
        115                 120                 125             
Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp Val Phe Lys Val Ala
    130                 135                 140                 
Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser Ile Phe
145                 150                 155                 160 
Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile Pro Ala Asp Thr Leu
                165                 170                 175     
Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr His Ala Asn Val Ala
            180                 185                 190         
Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln Ser Thr His Val
        195                 200                 205             
Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile
    210                 215                 220                 
Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly
225                 230                 235                 240 
Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met
                245                 250                 255     
Tyr Asn Asp Ala Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe
            260                 265                 270         
Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu Ser Ala
        275                 280                 285             
Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile Asp Met Val Leu Ala
    290                 295                 300                 
Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met
305                 310                 315                 320 
Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val Leu Leu Leu Asp Asn
                325                 330                 335     
Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu Val His Cys Ala Asp
            340                 345                 350         
Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr Arg Gln Trp Thr Asp
        355                 360                 365             
Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg Glu Ser
    370                 375                 380                 
Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser Val Glu
385                 390                 395                 400 
Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala His Pro Leu Trp Glu
                405                 410                 415     
Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Leu Leu Asp Thr
            420                 425                 430         
Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys Ile Pro Arg Ser Pro
        435                 440                 445             
Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro Asp Arg Phe Gln Phe
    450                 455                 460                 
Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp Glu Glu Glu Glu Glu
465                 470                 475                 480 
Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala Leu Glu Leu Pro Asp
                485                 490                 495     
Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp Pro Gly Asp Leu Pro
            500                 505                 510         
Leu Asp Asn Gln Arg Thr
        515             


<210> 8778
<211> 202
<212> PRT
<213> Homo sapiens

<400> 8778
Pro Val Pro Gln Arg Pro Ala Ser Gln Leu Leu Ala Pro Phe Ala Ala
 1               5                  10                  15      
Glu Ala Leu Pro Gly Ala Pro Arg Ala Ala Met Ala Gln His Phe Ser
            20                  25                  30          
Leu Ala Ala Cys Asp Val Val Gly Phe Asp Leu Asp His Thr Leu Cys
        35                  40                  45              
Arg Tyr Asn Leu Pro Glu Ser Ala Pro Leu Ile Tyr Asn Ser Phe Ala
    50                  55                  60                  
Gln Phe Leu Val Lys Glu Lys Gly Tyr Asp Lys Glu Leu Leu Asn Val
65                  70                  75                  80  
Thr Pro Glu Asp Trp Asp Phe Cys Cys Lys Gly Leu Ala Leu Asp Leu
                85                  90                  95      
Glu Asp Gly Asn Phe Leu Lys Leu Ala Asn Asn Gly Thr Val Leu Arg
            100                 105                 110         
Ala Ser His Gly Thr Lys Met Met Thr Pro Glu Val Leu Ala Glu Ala
        115                 120                 125             
Tyr Gly Lys Lys Glu Trp Lys His Phe Leu Ser Asp Thr Gly Met Ala
    130                 135                 140                 
Cys Arg Ser Gly Lys Tyr Tyr Phe Tyr Asp Asn Tyr Phe Asp Leu Pro
145                 150                 155                 160 
Gly Ala Leu Leu Cys Ala Arg Val Val Asp Tyr Leu Thr Lys Leu Asn
                165                 170                 175     
Asn Gly Gln Lys Thr Phe Asp Phe Trp Lys Asp Ile Val Ala Ala Ile
            180                 185                 190         
Gln His Asn Tyr Lys Met Ser Ala Phe Lys
        195                 200         


<210> 8779
<211> 455
<212> PRT
<213> Homo sapiens

<400> 8779
Met Ala Gln His Phe Ser Leu Ala Ala Cys Asp Val Val Gly Phe Asp
 1               5                  10                  15      
Leu Asp His Thr Leu Cys Arg Tyr Asn Leu Pro Glu Ser Ala Pro Leu
            20                  25                  30          
Ile Tyr Asn Ser Phe Ala Gln Phe Leu Val Lys Glu Lys Gly Tyr Asp
        35                  40                  45              
Lys Glu Leu Leu Asn Val Thr Pro Glu Asp Trp Asp Phe Cys Cys Lys
    50                  55                  60                  
Gly Leu Ala Leu Asp Leu Glu Asp Gly Asn Phe Leu Lys Leu Ala Asn
65                  70                  75                  80  
Asn Gly Thr Val Leu Arg Ala Ser His Gly Thr Lys Met Met Thr Pro
                85                  90                  95      
Glu Val Leu Ala Glu Ala Tyr Gly Lys Lys Glu Trp Lys His Phe Leu
            100                 105                 110         
Ser Asp Thr Gly Met Ala Cys Arg Ser Gly Lys Tyr Tyr Phe Tyr Asp
        115                 120                 125             
Asn Tyr Phe Asp Leu Pro Gly Ala Leu Leu Cys Ala Arg Val Val Asp
    130                 135                 140                 
Tyr Leu Thr Lys Leu Asn Asn Gly Gln Lys Thr Phe Asp Phe Trp Lys
145                 150                 155                 160 
Asp Ile Val Ala Ala Ile Gln His Asn Tyr Lys Met Ser Ala Phe Lys
                165                 170                 175     
Glu Asn Cys Gly Ile Tyr Phe Pro Glu Ile Lys Arg Asp Pro Gly Arg
            180                 185                 190         
Tyr Leu His Ser Cys Pro Glu Ser Val Lys Lys Trp Leu Arg Gln Leu
        195                 200                 205             
Lys Asn Ala Gly Lys Ile Leu Leu Leu Ile Thr Ser Ser His Ser Asp
    210                 215                 220                 
Tyr Cys Arg Leu Leu Cys Glu Tyr Ile Leu Gly Asn Asp Phe Thr Asp
225                 230                 235                 240 
Leu Phe Asp Ile Val Ile Thr Asn Ala Leu Lys Pro Gly Phe Phe Ser
                245                 250                 255     
His Leu Pro Ser Gln Arg Pro Phe Arg Thr Leu Glu Asn Asp Glu Glu
            260                 265                 270         
Gln Glu Ala Leu Pro Ser Leu Asp Lys Pro Gly Trp Tyr Ser Gln Gly
        275                 280                 285             
Asn Ala Val His Leu Tyr Glu Leu Leu Lys Lys Met Thr Gly Lys Pro
    290                 295                 300                 
Glu Pro Lys Val Val Tyr Phe Gly Asp Ser Met His Ser Asp Ile Phe
305                 310                 315                 320 
Pro Ala Arg His Tyr Ser Asn Trp Glu Thr Val Leu Ile Leu Glu Glu
                325                 330                 335     
Leu Arg Gly Asp Glu Gly Thr Arg Ser Gln Arg Pro Glu Glu Ser Glu
            340                 345                 350         
Pro Leu Glu Lys Lys Gly Lys Tyr Glu Gly Pro Lys Ala Lys Pro Leu
        355                 360                 365             
Asn Thr Ser Ser Lys Lys Trp Gly Ser Phe Phe Ile Asp Ser Val Leu
    370                 375                 380                 
Gly Leu Glu Asn Thr Glu Asp Ser Leu Val Tyr Thr Trp Ser Cys Lys
385                 390                 395                 400 
Arg Ile Ser Thr Tyr Ser Thr Ile Ala Ile Pro Ser Ile Glu Ala Ile
                405                 410                 415     
Ala Glu Leu Pro Leu Asp Tyr Lys Phe Thr Arg Phe Ser Ser Ser Asn
            420                 425                 430         
Ser Lys Thr Ala Gly Tyr Tyr Pro Asn Pro Pro Leu Val Leu Ser Ser
        435                 440                 445             
Asp Glu Thr Leu Ile Ser Lys
    450                 455 


<210> 8780
<211> 431
<212> PRT
<213> Homo sapiens

<400> 8780
Met Gln Arg Pro Leu Arg Val Ala Gln Gly Pro Arg Pro Ala Arg Gly
 1               5                  10                  15      
Cys Ser Ser Ala Asp Ser Ser Arg Ser Ser Ser Ala Ser Pro Leu Ala
            20                  25                  30          
Ala Cys Ala Gly Trp Ala Pro Ser Ala Leu Cys Pro Thr Thr Ser Pro
        35                  40                  45              
Ser Arg Arg Tyr Gly Pro Trp Ser Ile Val Pro Ile Pro Ser Ser Asn
    50                  55                  60                  
Glu Glu Ile Arg Leu Val Asp Asp Ala Phe Gly Lys Ile Cys His Met
65                  70                  75                  80  
Val Ser Asp Gly Ser Trp Val Val His Val Gln Ala Ala Lys Leu Leu
                85                  90                  95      
Gly Ser Met Glu Gln Val Ser Ser His Phe Leu Glu Gln Thr Leu Asp
            100                 105                 110         
Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg Thr Ala His Glu Arg
        115                 120                 125             
Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser Ser Gly Arg Lys Trp
    130                 135                 140                 
Glu Asp Asp Ala Pro Lys Glu Glu Val Asp Thr Gly Ala Val Asn Leu
145                 150                 155                 160 
Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His Gly Leu Glu Asp Glu
                165                 170                 175     
Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala Leu Cys Met Leu Ala
            180                 185                 190         
Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu Asp Phe Leu Val Asp
        195                 200                 205             
Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu Gln Ser Ile His Thr
    210                 215                 220                 
Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu Asp Gln Leu Asp
225                 230                 235                 240 
Thr Val Leu Ala Val Leu Glu Asp Ser Ala Arg Asp Ile Arg Glu Ala
                245                 250                 255     
Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser Thr Lys Glu Gly Ile
            260                 265                 270         
His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu Thr Lys Tyr Pro Thr
        275                 280                 285             
Asp Arg Asp Ser Ile Trp Lys Cys Leu Lys Phe Leu Gly Ser Arg His
    290                 295                 300                 
Pro Thr Leu Val Leu Pro Leu Val Pro Glu Leu Leu Ser Thr His Pro
305                 310                 315                 320 
Phe Phe Asp Thr Ala Glu Pro Asp Met Asp Asp Pro Ala Tyr Ile Ala
                325                 330                 335     
Val Leu Val Leu Ile Phe Asn Ala Ala Lys Thr Cys Pro Thr Met Arg
            340                 345                 350         
Ala Leu Phe Ser Asp His Thr Val Arg His Tyr Ala Tyr Leu Arg Asp
        355                 360                 365             
Ser Leu Ser His Leu Val Pro Ala Leu Arg Leu Pro Gly Arg Lys Leu
    370                 375                 380                 
Val Ser Ser Ala Val Ser Pro Ser Ile Ile Pro Gln Glu Asp Pro Ser
385                 390                 395                 400 
Gln Gln Phe Leu Gln Gln Ser Leu Glu Arg Val Tyr Ser Leu Gln His
                405                 410                 415     
Leu Asp Pro Gln Gly Ala Gln Glu Leu Leu Glu Phe Thr Ile Arg
            420                 425                 430     


<210> 8781
<211> 342
<212> PRT
<213> Homo sapiens

<400> 8781
Met Val Ser Asp Gly Ser Trp Val Val His Val Gln Ala Ala Lys Leu
 1               5                  10                  15      
Leu Gly Ser Met Glu Gln Val Ser Ser His Phe Leu Glu Gln Thr Leu
            20                  25                  30          
Asp Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg Thr Ala His Glu
        35                  40                  45              
Arg Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser Ser Gly Arg Lys
    50                  55                  60                  
Trp Glu Asp Asp Ala Pro Lys Glu Glu Val Asp Thr Gly Ala Val Asn
65                  70                  75                  80  
Leu Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His Gly Leu Glu Asp
                85                  90                  95      
Glu Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala Leu Cys Met Leu
            100                 105                 110         
Ala Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu Asp Phe Leu Val
        115                 120                 125             
Asp Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu Gln Ser Ile His
    130                 135                 140                 
Thr Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu Asp Gln Leu
145                 150                 155                 160 
Asp Thr Val Leu Ala Val Leu Glu Asp Ser Ala Arg Asp Ile Arg Glu
                165                 170                 175     
Ala Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser Thr Lys Glu Gly
            180                 185                 190         
Ile His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu Thr Lys Cys Leu
        195                 200                 205             
Lys Phe Leu Gly Ser Arg His Pro Thr Leu Val Leu Pro Leu Val Pro
    210                 215                 220                 
Glu Leu Leu Ser Thr His Pro Phe Phe Asp Thr Ala Glu Pro Asp Met
225                 230                 235                 240 
Asp Asp Pro Ala Tyr Ile Ala Val Leu Val Leu Ile Phe Asn Ala Ala
                245                 250                 255     
Lys Thr Cys Pro Thr Met Arg Ala Leu Phe Ser Asp His Thr Val Arg
            260                 265                 270         
His Tyr Ala Tyr Leu Arg Asp Ser Leu Ser His Leu Val Pro Ala Leu
        275                 280                 285             
Arg Leu Pro Gly Arg Lys Leu Val Ser Ser Ala Val Ser Pro Ser Ile
    290                 295                 300                 
Ile Pro Gln Glu Asp Pro Ser Gln Gln Phe Leu Gln Gln Ser Leu Glu
305                 310                 315                 320 
Arg Val Tyr Ser Leu Gln His Leu Asp Pro Gln Gly Ala Gln Glu Leu
                325                 330                 335     
Leu Glu Phe Thr Ile Arg
            340         


<210> 8782
<211> 790
<212> PRT
<213> Homo sapiens

<400> 8782
Leu Gly Asn Leu Gly Ser Leu Glu Lys Ser Val Thr Lys Asp Ala Glu
 1               5                  10                  15      
Gly Leu Ala Ala Arg Asp Val Gln Lys Ile Ile Gly Asp Tyr Phe Ser
            20                  25                  30          
Asp Gln Asp Pro Arg Val Arg Thr Ala Ala Ile Lys Ala Met Leu Gln
        35                  40                  45              
Leu His Glu Arg Gly Leu Lys Leu His Gln Thr Ile Tyr Asn Gln Ala
    50                  55                  60                  
Cys Lys Leu Leu Ser Asp Asp Tyr Glu Gln Val Arg Ser Ala Ala Val
65                  70                  75                  80  
Gln Leu Ile Trp Val Val Ser Gln Leu Tyr Pro Glu Ser Ile Val Pro
                85                  90                  95      
Ile Pro Ser Ser Asn Glu Glu Ile Arg Leu Val Asp Asp Ala Phe Gly
            100                 105                 110         
Lys Ile Cys His Met Val Ser Asp Gly Ser Trp Val Val Arg Val Gln
        115                 120                 125             
Ala Ala Lys Leu Leu Gly Ser Met Glu Gln Val Ser Ser His Phe Leu
    130                 135                 140                 
Glu Gln Thr Leu Asp Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg
145                 150                 155                 160 
Thr Ala His Glu Arg Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser
                165                 170                 175     
Ser Gly Arg Lys Trp Gly Asp Asp Ala Pro Lys Glu Glu Val Asp Thr
            180                 185                 190         
Gly Ala Val Asn Leu Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His
        195                 200                 205             
Gly Leu Glu Asp Glu Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala
    210                 215                 220                 
Leu Cys Met Leu Ala Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu
225                 230                 235                 240 
Asp Phe Leu Val Asp Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu
                245                 250                 255     
Gln Ser Ile His Thr Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg
            260                 265                 270         
Glu Asp Gln Leu Asp Thr Val Leu Ala Val Leu Glu Asp Ser Ser Arg
        275                 280                 285             
Asp Ile Arg Glu Ala Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser
    290                 295                 300                 
Thr Lys Glu Gly Ile His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu
305                 310                 315                 320 
Thr Lys Tyr Pro Thr Asp Arg Asp Ser Ile Trp Lys Cys Leu Lys Phe
                325                 330                 335     
Leu Gly Ser Arg His Pro Thr Leu Val Leu Pro Leu Val Pro Glu Leu
            340                 345                 350         
Leu Ser Thr His Pro Phe Phe Asp Thr Ala Glu Pro Asp Met Asp Asp
        355                 360                 365             
Pro Ala Tyr Ile Ala Val Leu Val Leu Ile Phe Asn Ala Ala Lys Thr
    370                 375                 380                 
Cys Pro Thr Met Pro Ala Leu Phe Ser Asp His Thr Phe Arg His Tyr
385                 390                 395                 400 
Ala Tyr Leu Arg Asp Ser Leu Ser His Leu Val Pro Ala Leu Arg Leu
                405                 410                 415     
Pro Gly Arg Lys Leu Val Ser Ser Ala Val Ser Pro Ser Ile Ile Pro
            420                 425                 430         
Gln Glu Asp Pro Ser Gln Gln Phe Leu Gln Gln Ser Leu Glu Arg Val
        435                 440                 445             
Tyr Ser Leu Gln His Leu Asp Pro Gln Gly Ala Gln Glu Leu Leu Glu
    450                 455                 460                 
Phe Thr Ile Arg Asp Leu Gln Arg Leu Gly Glu Leu Gln Ser Glu Leu
465                 470                 475                 480 
Ala Gly Val Ala Asp Phe Ser Ala Thr Tyr Leu Arg Cys Gln Leu Leu
                485                 490                 495     
Leu Ile Lys Ala Leu Gln Glu Lys Leu Trp Asn Val Ala Ala Pro Leu
            500                 505                 510         
Tyr Leu Lys Gln Ser Asp Leu Ala Ser Ala Ala Ala Lys Gln Ile Met
        515                 520                 525             
Glu Glu Thr Tyr Lys Met Glu Phe Met Tyr Ser Gly Val Glu Asn Lys
    530                 535                 540                 
Gln Val Val Ile Ile His His Met Arg Leu Gln Ala Lys Ala Leu Gln
545                 550                 555                 560 
Leu Ile Val Thr Ala Arg Thr Thr Arg Gly Leu Asp Pro Leu Phe Gly
                565                 570                 575     
Met Cys Glu Lys Phe Leu Gln Glu Val Asp Phe Phe Gln Arg Tyr Phe
            580                 585                 590         
Ile Ala Asp Leu Pro His Leu Gln Asp Ser Phe Val Asp Lys Leu Leu
        595                 600                 605             
Asp Leu Met Pro Arg Leu Met Thr Ser Lys Pro Ala Glu Val Val Lys
    610                 615                 620                 
Ile Leu Gln Thr Met Leu Arg Gln Ser Ala Phe Leu His Leu Pro Leu
625                 630                 635                 640 
Pro Glu Gln Ile His Lys Ala Ser Ala Thr Ile Ile Glu Pro Ala Gly
                645                 650                 655     
Glu Ser Asp Asn Pro Leu Arg Phe Thr Ser Gly Leu Val Val Ala Leu
            660                 665                 670         
Asp Val Asp Ala Thr Leu Glu His Val Gln Asp Pro Gln Asn Thr Val
        675                 680                 685             
Lys Val Gln Val Leu Tyr Pro Asp Gly Gln Ala Gln Met Ile His Pro
    690                 695                 700                 
Lys Pro Ala Asp Phe Arg Asn Pro Gly Pro Gly Arg His Arg Leu Ile
705                 710                 715                 720 
Thr Gln Val Tyr Leu Ser His Thr Ala Trp Thr Glu Ala Cys Gln Val
                725                 730                 735     
Glu Val Arg Leu Leu Leu Ala Tyr Asn Ser Ser Ala Arg Ile Pro Lys
            740                 745                 750         
Cys Pro Trp Met Glu Gly Gly Glu Met Ser Pro Gln Val Glu Thr Ser
        755                 760                 765             
Ile Glu Gly Thr Ile Pro Phe Ser Lys Pro Val Lys Val Tyr Ile Met
    770                 775                 780                 
Pro Lys Pro Ala Arg Arg
785                 790 


<210> 8783
<211> 505
<212> PRT
<213> Homo sapiens

<400> 8783
Met Ala Ala His Leu Lys Lys Arg Val Tyr Glu Glu Phe Thr Lys Val
 1               5                  10                  15      
Val Gln Pro Gln Glu Glu Ile Ala Thr Lys Lys Leu Arg Leu Thr Lys
            20                  25                  30          
Pro Ser Lys Ser Ala Ala Leu His Ile Asp Leu Cys Lys Ala Thr Ser
        35                  40                  45              
Pro Ala Asp Ala Leu Gln Tyr Leu Leu Gln Phe Ala Arg Lys Pro Val
    50                  55                  60                  
Glu Ala Glu Ser Val Glu Gly Val Val Arg Ile Leu Leu Glu His Tyr
65                  70                  75                  80  
Tyr Lys Glu Asn Asp Pro Ser Val Arg Leu Lys Ile Ala Ser Leu Leu
                85                  90                  95      
Gly Leu Leu Ser Lys Thr Ala Gly Phe Ser Pro Asp Cys Ile Met Asp
            100                 105                 110         
Asp Ala Ile Asn Ile Leu Gln Asn Glu Lys Ser His Gln Val Leu Ala
        115                 120                 125             
Gln Leu Leu Asp Thr Leu Leu Ala Ile Gly Thr Lys Leu Pro Glu Asn
    130                 135                 140                 
Gln Ala Ile Gln Met Arg Leu Val Asp Val Ala Cys Lys His Leu Thr
145                 150                 155                 160 
Asp Thr Ser His Gly Val Arg Asn Lys Cys Leu Gln Leu Leu Gly Asn
                165                 170                 175     
Leu Gly Ser Leu Glu Lys Ser Val Thr Lys Asp Ala Glu Gly Leu Ala
            180                 185                 190         
Ala Arg Asp Val Gln Lys Ile Ile Gly Asp Tyr Phe Ser Asp Gln Asp
        195                 200                 205             
Pro Arg Val Arg Thr Ala Ala Ile Lys Ala Met Leu Gln Leu His Glu
    210                 215                 220                 
Arg Gly Leu Lys Leu His Gln Thr Ile Tyr Asn Gln Ala Cys Lys Leu
225                 230                 235                 240 
Leu Ser Asp Asp Tyr Glu Gln Val Arg Ser Ala Ala Val Gln Leu Ile
                245                 250                 255     
Trp Val Val Ser Gln Leu Tyr Pro Glu Ser Ile Val Pro Ile Pro Ser
            260                 265                 270         
Ser Asn Glu Glu Ile Arg Leu Val Asp Asp Ala Phe Gly Lys Ile Cys
        275                 280                 285             
His Met Val Ser Asp Gly Ser Trp Val Val Arg Val Gln Ala Ala Lys
    290                 295                 300                 
Leu Leu Gly Ser Met Glu Gln Val Ser Ser His Phe Leu Glu Gln Thr
305                 310                 315                 320 
Leu Asp Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg Thr Ala His
                325                 330                 335     
Glu Arg Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser Ser Gly Arg
            340                 345                 350         
Lys Trp Gly Asp Asp Ala Pro Lys Glu Glu Val Asp Thr Gly Ala Val
        355                 360                 365             
Asn Leu Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His Gly Leu Glu
    370                 375                 380                 
Asp Glu Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala Leu Cys Met
385                 390                 395                 400 
Leu Ala Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu Asp Phe Leu
                405                 410                 415     
Val Asp Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu Gln Ser Ile
            420                 425                 430         
His Thr Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu Asp Gln
        435                 440                 445             
Leu Asp Thr Val Leu Ala Val Leu Glu Asp Ser Ser Arg Asp Ile Arg
    450                 455                 460                 
Glu Ala Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser Thr Lys Glu
465                 470                 475                 480 
Gly Ile His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu Thr Lys Tyr
                485                 490                 495     
Pro Thr Asp Arg Asp Ser Ile Trp Lys
            500                 505 


<210> 8784
<211> 439
<212> PRT
<213> Homo sapiens

<400> 8784
Met Gln Arg Pro Leu Arg Val Ala Gln Gly Pro Arg Pro Ala Arg Gly
 1               5                  10                  15      
Cys Ser Ser Ala Asp Ser Ser Arg Ser Ser Ser Ala Ser Pro Leu Ala
            20                  25                  30          
Ala Cys Ala Gly Trp Ala Pro Ser Ala Leu Cys Pro Thr Thr Leu Pro
        35                  40                  45              
Ser Arg Arg Tyr Gly Pro Trp Asn Ile Val Pro Ile Pro Ser Ser Asn
    50                  55                  60                  
Glu Glu Ile Arg Leu Val Asp Asp Ala Phe Gly Lys Ile Cys His Met
65                  70                  75                  80  
Val Gly Asp Gly Ser Trp Val Val His Val Gln Ala Ala Lys Leu Leu
                85                  90                  95      
Gly Ser Met Glu Gln Val Ser Ser His Phe Leu Glu Gln Thr Leu Asp
            100                 105                 110         
Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg Thr Ala His Glu Arg
        115                 120                 125             
Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser Ser Gly Arg Lys Trp
    130                 135                 140                 
Glu Asp Asp Ala Pro Lys Glu Glu Val Asp Thr Gly Ala Val Asn Leu
145                 150                 155                 160 
Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His Gly Leu Glu Asp Glu
                165                 170                 175     
Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala Leu Cys Met Leu Ala
            180                 185                 190         
Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu Asp Phe Leu Val Asp
        195                 200                 205             
Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu Gln Ser Ile His Thr
    210                 215                 220                 
Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu Asp Gln Leu Asp
225                 230                 235                 240 
Thr Val Leu Ala Val Leu Glu Asp Ser Ser Arg Gly Ile Arg Glu Ala
                245                 250                 255     
Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser Thr Lys Glu Gly Ile
            260                 265                 270         
His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu Thr Lys Tyr Pro Thr
        275                 280                 285             
Asp Arg Asp Ser Ile Trp Lys Cys Leu Lys Phe Leu Gly Ser Arg His
    290                 295                 300                 
Pro Thr Leu Val Leu Pro Leu Val Pro Glu Leu Leu Ser Thr His Pro
305                 310                 315                 320 
Phe Phe Asp Thr Ala Glu Pro Asp Met Asp Asp Pro Ala Tyr Ile Ala
                325                 330                 335     
Val Leu Val Leu Ile Phe Asn Ala Ala Lys Thr Cys Pro Thr Met Arg
            340                 345                 350         
Ala Leu Phe Ser Asp His Thr Val Arg His Tyr Ala Tyr Leu Arg Asp
        355                 360                 365             
Ser Leu Ser His Leu Val Pro Ala Leu Arg Leu Pro Gly Arg Lys Leu
    370                 375                 380                 
Val Ser Ser Ala Val Ser Pro Ser Ile Ile Pro Gln Glu Asp Pro Ser
385                 390                 395                 400 
Gln Gln Leu Leu Gln Gln Ser Leu Glu Gly Val Cys Ser Leu Gln His
                405                 410                 415     
Leu Asp Pro Gln Gly Ala Gln Glu Leu Leu Glu Phe Thr Ile Arg Pro
            420                 425                 430         
Cys Arg Lys Ser Arg Gly Met
        435                 


<210> 8785
<211> 558
<212> PRT
<213> Homo sapiens

<400> 8785
Met Tyr Arg Tyr Leu Ala Lys Ala Leu Leu Pro Ser Arg Ala Gly Pro
 1               5                  10                  15      
Ala Ala Leu Gly Ser Ala Ala Asn His Ser Ala Ala Leu Leu Gly Arg
            20                  25                  30          
Gly Arg Gly Gln Pro Ala Ala Ala Ser Gln Pro Gly Leu Ala Leu Ala
        35                  40                  45              
Ala Arg Arg His Tyr Ser Glu Leu Val Ala Asp Arg Glu Asp Asp Pro
    50                  55                  60                  
Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile
65                  70                  75                  80  
Val Glu Asp Lys Leu Val Lys Asp Leu Arg Thr Gln Glu Ser Glu Glu
                85                  90                  95      
Gln Lys Arg Asn Arg Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys
            100                 105                 110         
Asn His Val Leu Ser Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser
        115                 120                 125             
Trp Glu Val Ile Glu Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr
    130                 135                 140                 
Pro Cys Lys Gly Gly Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu
145                 150                 155                 160 
Val Lys Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp
                165                 170                 175     
Val Pro Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn
            180                 185                 190         
Tyr Thr Glu Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu
        195                 200                 205             
Leu Ala Lys Lys Gly Phe Ile Gly Pro Gly Val Asp Val Pro Ala Pro
    210                 215                 220                 
Asp Met Asn Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr
225                 230                 235                 240 
Ala Ser Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr
                245                 250                 255     
Gly Lys Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr
            260                 265                 270         
Gly Arg Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser
        275                 280                 285             
Tyr Met Ser Ile Leu Gly Met Thr Pro Gly Phe Arg Asp Lys Thr Phe
    290                 295                 300                 
Val Val Gln Gly Phe Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu
305                 310                 315                 320 
His Arg Phe Gly Ala Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser
                325                 330                 335     
Ile Trp Asn Pro Asp Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys
            340                 345                 350         
Leu Gln His Gly Ser Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu
        355                 360                 365             
Gly Ser Ile Leu Glu Val Asp Cys Asp Ile Leu Ile Pro Ala Ala Thr
    370                 375                 380                 
Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile
385                 390                 395                 400 
Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile
                405                 410                 415     
Phe Leu Glu Arg Asn Ile Leu Val Ile Pro Asp Leu Tyr Leu Asn Ala
            420                 425                 430         
Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His
        435                 440                 445             
Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr
    450                 455                 460                 
His Leu Leu Leu Ser Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys
465                 470                 475                 480 
His Gly Gly Thr Ile Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Ser
                485                 490                 495     
Ile Ser Gly Ala Ser Glu Lys Asp Ile Val His Ser Ala Leu Ala Tyr
            500                 505                 510         
Thr Met Glu Arg Ser Ala Arg Gln Ile Met His Thr Ala Met Lys Tyr
        515                 520                 525             
Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu
    530                 535                 540                 
Lys Val Phe Lys Val Tyr Ser Glu Ala Gly Val Thr Phe Thr
545                 550                 555             


<210> 8786
<211> 1618
<212> PRT
<213> Homo sapiens

<400> 8786
Gly Arg Gly Arg Arg Arg Arg Arg Asn Gly Arg Gly Ala Glu Pro Pro
 1               5                  10                  15      
Pro Pro Lys Ala Pro Ser Leu Arg Pro Arg Thr Gly Ala Val Ala Trp
            20                  25                  30          
Arg Ser Lys Val Pro Pro Ser Pro Gln Gly Arg Arg Ala Gln Ala Arg
        35                  40                  45              
Gly Leu Phe Gly Gly Ser Ala Pro Gly Leu His Leu Glu Ala Ala Pro
    50                  55                  60                  
Asp Gly Asp Gly Gln Arg Leu Leu Pro Ser Gly Ser Arg Ala Gly Arg
65                  70                  75                  80  
Cys Glu Gly Thr Met Ala Leu Thr Pro Gly Trp Gly Ser Ser Ala Gly
                85                  90                  95      
Pro Val Arg Pro Glu Leu Trp Leu Leu Leu Trp Ala Ala Ala Trp Arg
            100                 105                 110         
Leu Gly Ala Ser Ala Cys Pro Ala Leu Cys Thr Cys Thr Gly Thr Thr
        115                 120                 125             
Val Asp Cys His Gly Thr Gly Leu Gln Ala Ile Pro Lys Asn Ile Pro
    130                 135                 140                 
Arg Asn Thr Glu Arg Leu Glu Leu Asn Gly Asn Asn Ile Thr Arg Ile
145                 150                 155                 160 
His Lys Asn Asp Phe Ala Gly Leu Lys Gln Leu Arg Val Leu Gln Leu
                165                 170                 175     
Met Glu Asn Gln Ile Gly Val Val Glu Arg Gly Ala Phe Asp Asp Met
            180                 185                 190         
Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg Asn Gln Leu His Met Leu
        195                 200                 205             
Pro Glu Leu Leu Phe Gln Asn Asn Gln Ala Leu Ser Arg Leu Asp Leu
    210                 215                 220                 
Ser Glu Asn Ala Ile Gln Ala Ile Pro Arg Lys Ala Phe Arg Gly Ala
225                 230                 235                 240 
Thr Asp Leu Lys Asn Leu Gln Leu Asp Lys Asn Gln Ile Ser Cys Ile
                245                 250                 255     
Glu Glu Gly Ala Phe Arg Ala Leu Arg Gly Leu Glu Val Leu Thr Leu
            260                 265                 270         
Asn Asn Asn Asn Ile Thr Thr Ile Pro Val Ser Ser Phe Asn His Met
        275                 280                 285             
Pro Lys Leu Arg Thr Phe Arg Leu His Ser Asn His Leu Phe Cys Asp
    290                 295                 300                 
Cys His Leu Ala Trp Leu Ser Gln Trp Leu Arg Gln Arg Pro Thr Ile
305                 310                 315                 320 
Gly Leu Phe Thr Gln Cys Ser Gly Pro Ala Ser Leu Arg Gly Leu Asn
                325                 330                 335     
Val Ala Glu Val Gln Lys Ser Glu Phe Ser Cys Ser Gly Gln Gly Glu
            340                 345                 350         
Ala Gly Arg Val Pro Thr Cys Thr Leu Ser Ser Gly Ser Cys Pro Ala
        355                 360                 365             
Met Cys Thr Cys Ser Asn Gly Ile Val Asp Cys Arg Gly Lys Gly Leu
    370                 375                 380                 
Thr Ala Ile Pro Ala Asn Leu Pro Glu Thr Met Thr Glu Ile Arg Leu
385                 390                 395                 400 
Glu Leu Asn Gly Ile Lys Ser Ile Pro Pro Gly Ala Phe Ser Pro Tyr
                405                 410                 415     
Arg Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile Ala Glu Ile
            420                 425                 430         
Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser Leu Val Leu
        435                 440                 445             
Tyr Gly Asn Lys Ile Thr Asp Leu Pro Arg Gly Val Phe Gly Gly Leu
    450                 455                 460                 
Tyr Thr Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile Asn Cys Ile
465                 470                 475                 480 
Arg Pro Asp Ala Phe Gln Asp Leu Gln Asn Leu Ser Leu Leu Ser Leu
                485                 490                 495     
Tyr Asp Asn Lys Ile Gln Ser Leu Ala Lys Gly Thr Phe Thr Ser Leu
            500                 505                 510         
Arg Ala Ile Gln Thr Leu His Leu Ala Gln Asn Pro Phe Ile Cys Asp
        515                 520                 525             
Cys Asn Leu Lys Trp Leu Ala Asp Phe Leu Arg Thr Asn Pro Ile Glu
    530                 535                 540                 
Thr Ser Gly Ala Arg Cys Ala Ser Pro Arg Arg Leu Ala Asn Lys Arg
545                 550                 555                 560 
Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Ala Lys Glu Gln
                565                 570                 575     
Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Gln Leu Asn Ser Glu Cys Asn
            580                 585                 590         
Ser Asp Val Val Cys Pro His Lys Cys Arg Cys Glu Ala Asn Val Val
        595                 600                 605             
Glu Cys Ser Ser Leu Lys Leu Thr Lys Ile Pro Glu Arg Ile Pro Gln
    610                 615                 620                 
Ser Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu Ile Ser Ile Leu Glu
625                 630                 635                 640 
Ala Thr Gly Met Phe Lys Lys Leu Thr His Leu Lys Lys Ile Asn Leu
                645                 650                 655     
Ser Asn Asn Lys Val Ser Glu Ile Glu Asp Gly Ala Phe Glu Gly Ala
            660                 665                 670         
Ala Ser Val Ser Glu Leu His Leu Thr Ala Asn Gln Leu Glu Ser Ile
        675                 680                 685             
Arg Ser Gly Met Phe Arg Gly Leu Asp Gly Leu Arg Thr Leu Met Leu
    690                 695                 700                 
Arg Asn Asn Arg Ile Ser Cys Ile His Asn Asp Ser Phe Thr Gly Leu
705                 710                 715                 720 
Arg Asn Val Arg Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr Val
                725                 730                 735     
Ser Pro Gly Ala Phe Asp Thr Leu Gln Ser Leu Ser Thr Leu Asn Leu
            740                 745                 750         
Leu Ala Asn Pro Phe Asn Cys Asn Cys Gln Leu Ala Trp Leu Gly Gly
        755                 760                 765             
Trp Leu Arg Lys Arg Lys Ile Val Thr Gly Asn Pro Arg Cys Gln Asn
    770                 775                 780                 
Pro Asp Phe Leu Arg Gln Ile Pro Leu Gln Asp Val Ala Phe Pro Asp
785                 790                 795                 800 
Phe Arg Cys Glu Glu Gly Gln Glu Glu Gly Gly Cys Leu Pro Arg Pro
                805                 810                 815     
Gln Cys Pro Gln Glu Cys Ala Cys Leu Asp Thr Val Val Arg Cys Ser
            820                 825                 830         
Asn Lys His Leu Arg Ala Leu Pro Lys Gly Ile Pro Lys Asn Val Thr
        835                 840                 845             
Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu Val Pro Gly Gln Leu
    850                 855                 860                 
Ser Thr Phe Lys Tyr Leu Gln Leu Val Asp Leu Ser Asn Asn Lys Ile
865                 870                 875                 880 
Ser Ser Leu Ser Asn Ser Ser Phe Thr Asn Met Ser Gln Leu Thr Thr
                885                 890                 895     
Leu Ile Leu Ser Tyr Asn Ala Leu Gln Cys Ile Pro Pro Leu Ala Phe
            900                 905                 910         
Gln Gly Leu Arg Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp Ile
        915                 920                 925             
Ser Thr Leu Gln Glu Gly Ile Phe Ala Asp Val Thr Ser Leu Ser His
    930                 935                 940                 
Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp Cys His Leu Arg Trp
945                 950                 955                 960 
Leu Ser Ser Trp Val Lys Thr Gly Tyr Lys Glu Pro Gly Ile Ala Arg
                965                 970                 975     
Cys Ala Gly Pro Gln Asp Met Glu Gly Lys Leu Leu Leu Thr Thr Pro
            980                 985                 990         
Ala Lys Lys Phe Glu Cys Gln Gly Pro Pro Thr Leu Ala Val Gln Ala
        995                 1000                1005            
Lys Cys Asp Leu Cys Leu Ser Ser Pro Cys Gln Asn Gln Gly Thr Cys
    1010                1015                1020                
His Asn Asp Pro Leu Glu Val Tyr Arg Cys Ala Cys Pro Ser Gly Tyr
1025                1030                1035                1040
Lys Gly Arg Asp Cys Glu Val Ser Leu Asp Ser Cys Ser Ser Gly Pro
                1045                1050                1055    
Cys Glu Asn Gly Gly Thr Cys His Ala Gln Glu Gly Glu Asp Ala Pro
            1060                1065                1070        
Phe Thr Cys Ser Cys Pro Thr Gly Phe Glu Gly Pro Thr Cys Gly Val
        1075                1080                1085            
Asn Thr Asp Asp Cys Val Asp His Ala Cys Ala Asn Gly Gly Val Cys
    1090                1095                1100                
Val Asp Gly Val Gly Asn Tyr Thr Cys Gln Cys Pro Leu Gln Tyr Glu
1105                1110                1115                1120
Gly Lys Ala Cys Glu Gln Leu Val Asp Leu Cys Ser Pro Asp Leu Asn
                1125                1130                1135    
Pro Cys Gln His Glu Ala Gln Cys Val Gly Thr Pro Asp Gly Pro Arg
            1140                1145                1150        
Cys Glu Cys Met Pro Gly Tyr Ala Gly Asp Asn Cys Ser Glu Asn Gln
        1155                1160                1165            
Asp Asp Cys Arg Asp His Arg Cys Gln Asn Gly Ala Gln Cys Met Asp
    1170                1175                1180                
Glu Val Asn Ser Tyr Ser Cys Leu Cys Ala Glu Gly Tyr Ser Gly Gln
1185                1190                1195                1200
Leu Cys Glu Ile Pro Pro His Leu Pro Ala Pro Lys Ser Pro Cys Glu
                1205                1210                1215    
Gly Thr Glu Cys Gln Asn Gly Ala Asn Cys Val Asp Gln Gly Asn Arg
            1220                1225                1230        
Pro Val Cys Gln Cys Leu Pro Gly Phe Gly Gly Pro Glu Cys Glu Lys
        1235                1240                1245            
Leu Leu Ser Val Asn Phe Val Asp Arg Asp Thr Tyr Leu Gln Phe Thr
    1250                1255                1260                
Asp Leu Gln Asn Trp Pro Arg Ala Asn Ile Thr Leu Gln Val Ser Thr
1265                1270                1275                1280
Ala Glu Asp Asn Gly Ile Leu Leu Tyr Asn Gly Asp Asn Asp His Ile
                1285                1290                1295    
Ala Val Glu Leu Tyr Gln Gly His Val Arg Val Ser Tyr Asp Pro Gly
            1300                1305                1310        
Ser Tyr Pro Ser Ser Ala Ile Tyr Ser Ala Glu Thr Ile Asn Asp Gly
        1315                1320                1325            
Gln Phe His Thr Val Glu Leu Val Ala Phe Asp Gln Met Val Asn Leu
    1330                1335                1340                
Ser Ile Asp Gly Gly Ser Pro Met Thr Met Asp Asn Phe Gly Lys His
1345                1350                1355                1360
Tyr Thr Leu Asn Ser Glu Ala Pro Leu Tyr Val Gly Gly Met Pro Val
                1365                1370                1375    
Asp Val Asn Ser Ala Ala Phe Arg Leu Trp Gln Ile Leu Asn Gly Thr
            1380                1385                1390        
Gly Phe His Gly Cys Ile Arg Asn Leu Tyr Ile Asn Asn Glu Leu Gln
        1395                1400                1405            
Asp Phe Thr Lys Thr Gln Met Lys Pro Gly Val Val Pro Gly Cys Glu
    1410                1415                1420                
Pro Cys Arg Lys Leu Tyr Cys Leu His Gly Ile Cys Gln Pro Asn Ala
1425                1430                1435                1440
Thr Pro Gly Pro Met Cys His Cys Glu Ala Gly Trp Val Gly Leu His
                1445                1450                1455    
Cys Asp Gln Pro Ala Asp Gly Pro Cys His Gly His Lys Cys Val His
            1460                1465                1470        
Gly Gln Cys Val Pro Leu Asp Ala Leu Ser Tyr Ser Cys Gln Cys Gln
        1475                1480                1485            
Asp Gly Tyr Ser Gly Ala Leu Cys Asn Gln Ala Gly Ala Leu Ala Glu
    1490                1495                1500                
Pro Cys Arg Gly Leu Gln Cys Leu His Gly His Cys Gln Ala Ser Gly
1505                1510                1515                1520
Thr Lys Gly Ala His Cys Val Cys Asp Pro Gly Phe Ser Gly Glu Leu
                1525                1530                1535    
Cys Glu Gln Glu Ser Glu Cys Arg Gly Asp Pro Val Arg Asp Phe His
            1540                1545                1550        
Gln Val Gln Arg Gly Tyr Ala Ile Cys Gln Thr Thr Arg Pro Leu Ser
        1555                1560                1565            
Trp Val Glu Cys Arg Gly Ser Cys Pro Gly Gln Gly Cys Cys Gln Gly
    1570                1575                1580                
Leu Arg Leu Lys Arg Arg Lys Phe Thr Phe Glu Cys Ser Asp Gly Thr
1585                1590                1595                1600
Ser Phe Ala Glu Glu Val Glu Lys Pro Thr Lys Cys Gly Cys Ala Leu
                1605                1610                1615    
Cys Ala
        


<210> 8787
<211> 798
<212> PRT
<213> Homo sapiens

<400> 8787
Leu Trp Leu Leu Leu Trp Ala Ala Ala Trp Arg Leu Gly Ala Ser Ala
 1               5                  10                  15      
Cys Pro Ala Leu Cys Thr Cys Thr Gly Thr Thr Val Asp Cys His Gly
            20                  25                  30          
Thr Gly Leu Gln Ala Ile Pro Lys Asn Ile Pro Arg Asn Thr Glu Arg
        35                  40                  45              
Leu Glu Leu Asn Gly Asn Asn Ile Thr Arg Ile His Lys Asn Asp Phe
    50                  55                  60                  
Ala Gly Leu Lys Gln Leu Arg Val Leu Gln Leu Met Glu Asn Gln Ile
65                  70                  75                  80  
Gly Ala Val Glu Arg Gly Ala Phe Asp Asp Met Lys Glu Leu Glu Arg
                85                  90                  95      
Leu Arg Leu Asn Arg Asn Gln Leu His Met Leu Pro Glu Leu Leu Phe
            100                 105                 110         
Gln Asn Asn Gln Ala Leu Ser Arg Leu Asp Leu Ser Glu Asn Ala Ile
        115                 120                 125             
Gln Ala Ile Pro Arg Lys Ala Phe Arg Gly Ala Thr Asp Leu Lys Asn
    130                 135                 140                 
Leu Gln Leu Asp Lys Asn Gln Ile Ser Cys Ile Glu Glu Gly Ala Phe
145                 150                 155                 160 
Arg Ala Leu Arg Gly Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile
                165                 170                 175     
Thr Thr Ile Pro Val Ser Ser Phe Asn His Met Pro Lys Leu Arg Thr
            180                 185                 190         
Phe Arg Leu His Ser Asn His Leu Phe Cys Asp Cys His Leu Ala Trp
        195                 200                 205             
Leu Ser Gln Trp Leu Arg Gln Arg Pro Thr Ile Gly Leu Phe Thr Gln
    210                 215                 220                 
Cys Ser Gly Pro Ala Ser Leu Arg Gly Leu Asn Val Ala Glu Val Gln
225                 230                 235                 240 
Lys Ser Glu Phe Ser Cys Ser Gly Gln Gly Glu Ala Gly Arg Val Pro
                245                 250                 255     
Thr Cys Thr Leu Ser Ser Gly Ser Cys Pro Ala Met Cys Thr Cys Ser
            260                 265                 270         
Asn Gly Ile Val Asp Cys Arg Gly Lys Gly Leu Thr Ala Ile Pro Ala
        275                 280                 285             
Asn Leu Pro Glu Thr Met Thr Glu Ile Arg Leu Glu Leu Asn Gly Ile
    290                 295                 300                 
Lys Ser Ile Pro Pro Gly Ala Phe Ser Pro Tyr Arg Lys Leu Arg Arg
305                 310                 315                 320 
Ile Arg Pro Leu Ser Phe Cys Ser Pro Cys Arg Asp Leu Ser Asn Asn
                325                 330                 335     
Gln Ile Ala Glu Ile Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu
            340                 345                 350         
Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Asp Leu Pro Arg Gly
        355                 360                 365             
Val Phe Gly Gly Leu Tyr Thr Leu Gln Leu Leu Leu Leu Asn Ala Asn
    370                 375                 380                 
Lys Ile Asn Cys Ile Arg Pro Asp Ala Phe Gln Asp Leu Gln Asn Leu
385                 390                 395                 400 
Ser Leu Leu Ser Leu Tyr Asp Asn Lys Ile Gln Ser Leu Ala Lys Gly
                405                 410                 415     
Thr Phe Thr Ser Leu Arg Ala Ile Gln Thr Leu His Leu Ala Gln Asn
            420                 425                 430         
Pro Phe Ile Cys Asp Cys Asn Leu Lys Trp Leu Ala Asp Phe Leu Arg
        435                 440                 445             
Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Ala Ser Pro Arg Arg
    450                 455                 460                 
Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys
465                 470                 475                 480 
Ser Ala Lys Glu Gln Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Gln Leu
                485                 490                 495     
Asn Ser Glu Cys Asn Ser Asp Val Val Cys Pro His Lys Cys Arg Cys
            500                 505                 510         
Glu Ala Asn Val Val Glu Cys Ser Ser Leu Lys Leu Thr Lys Ile Pro
        515                 520                 525             
Glu Arg Ile Pro Gln Ser Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu
    530                 535                 540                 
Ile Ser Ile Leu Glu Ala Thr Gly Met Phe Lys Lys Leu Thr His Leu
545                 550                 555                 560 
Lys Lys Ile Asn Leu Ser Asn Asn Lys Val Ser Glu Ile Glu Asp Gly
                565                 570                 575     
Ala Phe Glu Gly Ala Ala Ser Val Ser Glu Leu His Leu Thr Ala Asn
            580                 585                 590         
Gln Leu Glu Ser Ile Arg Ser Gly Met Phe Arg Gly Leu Asp Gly Leu
        595                 600                 605             
Arg Thr Leu Met Leu Arg Asn Asn Arg Ile Ser Cys Ile His Asn Asp
    610                 615                 620                 
Ser Phe Thr Gly Leu Arg Asn Val Arg Leu Leu Ser Leu Tyr Asp Asn
625                 630                 635                 640 
Gln Ile Thr Thr Val Ser Pro Gly Ala Phe Asp Thr Leu Gln Ser Leu
                645                 650                 655     
Ser Thr Leu Asn Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Gln Leu
            660                 665                 670         
Ala Trp Leu Gly Gly Trp Leu Arg Lys Arg Lys Ile Val Thr Gly Asn
        675                 680                 685             
Pro Arg Cys Gln Asn Pro Asp Phe Leu Arg Gln Ile Pro Leu Gln Asp
    690                 695                 700                 
Val Ala Phe Pro Asp Phe Arg Cys Glu Glu Gly Gln Glu Glu Gly Gly
705                 710                 715                 720 
Cys Leu Pro Arg Pro Gln Cys Pro Gln Glu Cys Ala Cys Leu Asp Thr
                725                 730                 735     
Val Val Arg Cys Ser Asn Lys His Leu Arg Ala Leu Pro Lys Gly Ile
            740                 745                 750         
Pro Lys Asn Val Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu
        755                 760                 765             
Val Pro Gly Gln Leu Ser Thr Phe Lys Tyr Leu Gln Leu Val Ile Leu
    770                 775                 780                 
Ser Tyr Asn Ala Leu Gln Cys Ile Pro Pro Leu Ala Phe Pro
785                 790                 795             


<210> 8788
<211> 1516
<212> PRT
<213> Homo sapiens

<400> 8788
Met Ala Pro Ala Lys Ala Thr Asn Val Val Arg Leu Leu Leu Gly Ser
 1               5                  10                  15      
Thr Ala Leu Trp Leu Ser Gln Leu Gly Ser Gly Thr Val Ala Ala Ser
            20                  25                  30          
Lys Ser Val Thr Ala His Leu Ala Ala Lys Trp Pro Glu Thr Pro Leu
        35                  40                  45              
Leu Leu Glu Ala Ser Glu Phe Met Ala Glu Glu Ser Asn Glu Lys Phe
    50                  55                  60                  
Trp Gln Phe Leu Glu Thr Val Gln Glu Leu Ala Ile Tyr Lys Gln Thr
65                  70                  75                  80  
Glu Ser Asp Tyr Ser Tyr Tyr Asn Leu Ile Leu Lys Lys Ala Gly Gln
                85                  90                  95      
Phe Leu Asp Asn Leu His Ile Asn Leu Leu Lys Phe Ala Phe Ser Ile
            100                 105                 110         
Arg Ala Tyr Ser Pro Ala Ile Gln Met Phe Gln Gln Ile Ala Ala Asp
        115                 120                 125             
Glu Pro Pro Pro Asp Gly Cys Asn Ala Phe Val Val Ile His Lys Lys
    130                 135                 140                 
His Thr Cys Lys Ile Asn Glu Ile Lys Lys Leu Leu Lys Lys Ala Ala
145                 150                 155                 160 
Ser Arg Thr Arg Pro Tyr Leu Phe Lys Gly Asp His Lys Phe Pro Thr
                165                 170                 175     
Asn Lys Glu Asn Leu Pro Val Val Ile Leu Tyr Ala Glu Met Gly Thr
            180                 185                 190         
Arg Thr Phe Ser Ala Phe His Lys Val Leu Ser Glu Lys Ala Gln Asn
        195                 200                 205             
Glu Glu Ile Leu Tyr Val Leu Arg His Tyr Ile Gln Lys Pro Ser Ser
    210                 215                 220                 
Arg Lys Met Tyr Leu Ser Gly Tyr Gly Val Glu Leu Ala Ile Lys Ser
225                 230                 235                 240 
Thr Glu Tyr Lys Ala Leu Asp Asp Thr Gln Val Lys Thr Val Thr Asn
                245                 250                 255     
Thr Thr Val Glu Asp Glu Thr Glu Thr Asn Glu Val Gln Gly Phe Leu
            260                 265                 270         
Phe Gly Lys Leu Lys Glu Ile Tyr Ser Asp Leu Arg Asp Asn Leu Thr
        275                 280                 285             
Ala Phe Gln Lys Tyr Leu Ile Glu Ser Asn Lys Gln Met Met Pro Leu
    290                 295                 300                 
Lys Val Trp Glu Leu Gln Asp Leu Ser Phe Gln Ala Ala Ser Gln Ile
305                 310                 315                 320 
Met Ser Thr Pro Val Tyr Asp Ala Ile Lys Leu Met Lys Asp Ile Ser
                325                 330                 335     
Gln Asn Phe Pro Ile Lys Ala Arg Ser Leu Thr Arg Ile Ala Val Asn
            340                 345                 350         
Gln His Met Arg Glu Glu Ile Lys Glu Asn Gln Lys Asp Leu Gln Val
        355                 360                 365             
Arg Phe Lys Ile Gln Pro Gly Asp Ala Arg Leu Phe Ile Asn Gly Leu
    370                 375                 380                 
Arg Val Asp Met Asp Val Tyr Asp Ala Phe Ser Ile Leu Asp Met Leu
385                 390                 395                 400 
Lys Leu Glu Gly Lys Met Met Asn Gly Leu Arg Asn Leu Gly Ile Asn
                405                 410                 415     
Gly Glu Asp Met Ser Lys Phe Leu Lys Leu Asn Ser His Ile Trp Glu
            420                 425                 430         
Tyr Thr Tyr Val Leu Asp Ile Arg His Ser Ser Ile Met Trp Ile Asn
        435                 440                 445             
Asp Leu Glu Asn Asp Asp Leu Tyr Ile Thr Trp Pro Thr Ser Cys Gln
    450                 455                 460                 
Lys Leu Leu Lys Pro Val Phe Pro Gly Ser Val Pro Ser Ile Arg Arg
465                 470                 475                 480 
Asn Phe His Asn Leu Val Leu Phe Ile Asp Pro Ala Gln Glu Tyr Thr
                485                 490                 495     
Leu Asp Phe Ile Lys Leu Ala Asp Val Phe Tyr Ser His Glu Val Pro
            500                 505                 510         
Leu Arg Ile Gly Phe Val Phe Ile Leu Asn Thr Asp Asp Glu Val Asp
        515                 520                 525             
Gly Ala Asn Asp Ala Gly Val Ala Leu Trp Arg Ala Phe Asn Tyr Ile
    530                 535                 540                 
Ala Glu Glu Phe Asp Ile Ser Glu Ala Phe Ile Ser Ile Val His Met
545                 550                 555                 560 
Tyr Gln Lys Val Lys Lys Asp Gln Asn Ile Leu Thr Val Asp Asn Val
                565                 570                 575     
Lys Ser Val Leu Gln Asn Thr Phe Pro His Ala Asn Ile Trp Asp Ile
            580                 585                 590         
Leu Gly Ile His Ser Lys Tyr Asp Glu Glu Arg Lys Ala Gly Ala Ser
        595                 600                 605             
Phe Tyr Lys Met Thr Gly Leu Gly Pro Leu Pro Gln Ala Leu Tyr Asn
    610                 615                 620                 
Gly Glu Pro Phe Lys His Glu Glu Met Asn Ile Lys Glu Leu Lys Met
625                 630                 635                 640 
Ala Val Leu Gln Arg Met Met Asp Ala Ser Val Tyr Leu Gln Arg Glu
                645                 650                 655     
Val Phe Leu Gly Thr Leu Asn Asp Arg Thr Asn Ala Ile Asp Phe Leu
            660                 665                 670         
Met Asp Arg Asn Asn Val Val Pro Arg Ile Asn Thr Leu Ile Leu Arg
        675                 680                 685             
Thr Asn Gln Gln Tyr Leu Asn Leu Ile Ser Thr Ser Val Thr Ala Asp
    690                 695                 700                 
Val Glu Asp Phe Ser Thr Phe Phe Phe Leu Asp Ser Gln Asp Lys Ser
705                 710                 715                 720 
Ala Val Ile Ala Lys Asn Met Tyr Tyr Leu Thr Gln Asp Asp Glu Ser
                725                 730                 735     
Ile Ile Ser Ala Val Thr Leu Trp Ile Ile Ala Asp Phe Asp Lys Pro
            740                 745                 750         
Ser Gly Arg Lys Leu Leu Phe Asn Ala Leu Lys His Met Lys Thr Ser
        755                 760                 765             
Val His Ser Arg Leu Gly Ile Ile Tyr Asn Pro Thr Ser Lys Ile Asn
    770                 775                 780                 
Glu Glu Asn Thr Ala Ile Ser Arg Gly Ile Leu Ala Ala Phe Leu Thr
785                 790                 795                 800 
Gln Lys Asn Met Phe Leu Arg Ser Phe Leu Gly Gln Leu Ala Lys Glu
                805                 810                 815     
Glu Ile Ala Thr Thr Ile Tyr Ser Gly Asp Lys Ile Lys Thr Phe Leu
            820                 825                 830         
Ile Glu Gly Met Asp Lys Asn Ala Phe Glu Lys Lys Tyr Asn Thr Val
        835                 840                 845             
Gly Val Asn Ile Phe Arg Thr His Gln Leu Phe Cys Gln Asp Val Leu
    850                 855                 860                 
Lys Leu Arg Pro Gly Glu Met Gly Ile Val Ser Asn Gly Arg Phe Leu
865                 870                 875                 880 
Gly Pro Leu Asp Glu Asp Phe Tyr Ala Glu Asp Phe Tyr Leu Leu Glu
                885                 890                 895     
Lys Ile Thr Phe Ser Asn Leu Gly Glu Lys Ile Lys Gly Ile Val Glu
            900                 905                 910         
Asn Met Gly Ile Asn Ala Asn Asn Met Ser Asp Phe Ile Met Lys Val
        915                 920                 925             
Asp Ala Leu Met Ser Ser Val Pro Lys Arg Ala Ser Arg Tyr Asp Val
    930                 935                 940                 
Thr Phe Leu Arg Glu Asn His Ser Val Ile Lys Thr Asn Pro Gln Glu
945                 950                 955                 960 
Asn Asp Met Phe Phe Asn Val Ile Ala Ile Val Asp Pro Leu Thr Arg
                965                 970                 975     
Glu Ala Gln Lys Met Ala Gln Leu Leu Val Val Leu Gly Lys Ile Ile
            980                 985                 990         
Asn Leu Lys Ile Lys Leu Phe Met Asn Cys Arg Gly Arg Leu Ser Glu
        995                 1000                1005            
Ala Pro Leu Glu Ser Phe Tyr Arg Phe Val Leu Glu Pro Glu Leu Met
    1010                1015                1020                
Ser Gly Ala Asn Asp Val Ser Ser Leu Gly Pro Val Ala Lys Phe Leu
1025                1030                1035                1040
Asp Ile Pro Glu Ser Pro Leu Leu Ile Leu Asn Met Ile Thr Pro Glu
                1045                1050                1055    
Gly Trp Leu Val Glu Thr Val His Ser Asn Cys Asp Leu Asp Asn Ile
            1060                1065                1070        
His Leu Lys Asp Thr Glu Lys Thr Val Thr Ala Glu Tyr Glu Leu Glu
        1075                1080                1085            
Tyr Leu Leu Leu Glu Gly Gln Cys Phe Asp Lys Val Thr Glu Gln Pro
    1090                1095                1100                
Pro Arg Gly Leu Gln Phe Thr Leu Gly Thr Lys Asn Lys Pro Ala Val
1105                1110                1115                1120
Val Asp Thr Ile Val Met Ala His His Gly Tyr Phe Gln Leu Lys Ala
                1125                1130                1135    
Asn Pro Gly Ala Trp Ile Leu Arg Leu His Gln Gly Lys Ser Glu Asp
            1140                1145                1150        
Ile Tyr Gln Ile Val Gly His Glu Gly Thr Asp Ser Gln Ala Asp Leu
        1155                1160                1165            
Glu Asp Ile Ile Val Val Leu Asn Ser Phe Lys Ser Lys Ile Leu Lys
    1170                1175                1180                
Val Lys Val Lys Lys Glu Thr Asp Lys Ile Lys Glu Asp Ile Leu Thr
1185                1190                1195                1200
Asp Glu Asp Glu Lys Thr Lys Gly Leu Trp Asp Ser Ile Lys Ser Phe
                1205                1210                1215    
Thr Val Ser Leu His Lys Glu Asn Lys Lys Glu Lys Asp Val Leu Asn
            1220                1225                1230        
Ile Phe Ser Val Ala Ser Gly His Leu Tyr Glu Arg Phe Leu Arg Ile
        1235                1240                1245            
Met Met Leu Ser Val Leu Arg Asn Thr Lys Thr Pro Val Lys Phe Trp
    1250                1255                1260                
Leu Leu Lys Asn Tyr Leu Ser Pro Thr Phe Lys Glu Val Ile Pro His
1265                1270                1275                1280
Met Ala Lys Glu Tyr Gly Phe Arg Tyr Glu Leu Val Gln Tyr Arg Trp
                1285                1290                1295    
Pro Arg Trp Leu Arg Gln Gln Thr Glu Arg Gln Arg Ile Ile Trp Gly
            1300                1305                1310        
Tyr Lys Ile Leu Phe Leu Asp Val Leu Phe Pro Leu Ala Val Asp Lys
        1315                1320                1325            
Ile Ile Phe Val Asp Ala Asp Gln Ile Val Arg His Asp Leu Lys Glu
    1330                1335                1340                
Leu Arg Asp Phe Asp Leu Asp Gly Ala Pro Tyr Gly Tyr Thr Pro Phe
1345                1350                1355                1360
Cys Asp Ser Arg Arg Glu Met Asp Gly Tyr Arg Phe Trp Lys Thr Gly
                1365                1370                1375    
Tyr Trp Ala Ser His Leu Leu Arg Arg Lys Tyr His Ile Ser Ala Leu
            1380                1385                1390        
Tyr Val Val Asp Leu Lys Lys Phe Arg Arg Ile Gly Ala Gly Asp Arg
        1395                1400                1405            
Leu Arg Ser Gln Tyr Gln Ala Leu Ser Gln Asp Pro Asn Ser Leu Ser
    1410                1415                1420                
Asn Leu Asp Gln Asp Leu Pro Asn Asn Met Ile Tyr Gln Val Ala Ile
1425                1430                1435                1440
Lys Ser Leu Pro Gln Asp Trp Leu Trp Cys Glu Thr Trp Cys Asp Asp
                1445                1450                1455    
Glu Ser Lys Gln Arg Ala Lys Thr Ile Asp Leu Cys Asn Asn Pro Lys
            1460                1465                1470        
Thr Lys Glu Ser Lys Leu Lys Ala Ala Ala Arg Ile Val Pro Glu Trp
        1475                1480                1485            
Val Glu Tyr Asp Ala Glu Ile Arg Gln Leu Leu Asp His Leu Glu Asn
    1490                1495                1500                
Lys Lys Gln Asp Thr Ile Leu Thr His Asp Glu Leu
1505                1510                1515    


<210> 8789
<211> 266
<212> PRT
<213> Homo sapiens

<400> 8789
His Ala Ser Ala Ala Pro Pro Gly Arg Val Gly Arg Gly Ala Arg Cys
 1               5                  10                  15      
Leu Ala Ala Val Leu Thr Leu Met Arg Ser Arg Lys Leu Thr Gly Ala
            20                  25                  30          
Val Arg Ser Ser Ala Arg Leu Lys Ala Arg Ser Cys Ser Ala Ala Arg
        35                  40                  45              
Leu Ala Ser Ala Gln Glu Val Ala Gly Ser Thr Ser Ala Lys Thr Ala
    50                  55                  60                  
Cys Leu Thr Ser Ser Ser His Lys Ala Thr Asp Arg Arg Thr Ser Lys
65                  70                  75                  80  
Lys Phe Lys Cys Asp Lys Gly His Leu Val Lys Ser Glu Leu Gln Lys
                85                  90                  95      
Leu Val Pro Lys Asn Asp Ser Ala Ser Leu Pro Lys Val Thr Pro Glu
            100                 105                 110         
Thr Pro Cys Glu Asn Glu Phe Ala Glu Gly Ser Ala Leu Leu Pro Gly
        115                 120                 125             
Ser Glu Ala Gly Val Ser Val Gln Gln Gly Ala Ala Ser Leu Pro Leu
    130                 135                 140                 
Gly Gly Cys Arg Val Val Ser Asp Ser Arg Leu Ala Lys Thr Arg Asp
145                 150                 155                 160 
Gly Leu Ser Val Pro Lys His Ser Ala Gly Ser Gly Ala Glu Glu Ser
                165                 170                 175     
Asn Ser Ser Ser Thr Val Gln Lys Gln Asn Glu Pro Gly Leu Gln Thr
            180                 185                 190         
Glu Asp Val Gln Lys Pro Pro Leu Gln Met Asp Asn Ser Val Phe Leu
        195                 200                 205             
Asp Asp Asp Ser Asn Gln Pro Met Pro Val Ser Arg Phe Phe Gly Asn
    210                 215                 220                 
Val Glu Leu Met Gln Asp Leu Pro Pro Ala Ser Ser Ser Cys Pro Ser
225                 230                 235                 240 
Met Ser Arg Arg Glu Phe Arg Lys Met His Phe Arg Ala Lys Asp Asp
                245                 250                 255     
Asp Asp Asp Asp Asp Asp Asp Ala Glu Met
            260                 265     


<210> 8790
<211> 345
<212> PRT
<213> Homo sapiens

<400> 8790
Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val
 1               5                  10                  15      
Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg
            20                  25                  30          
Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg
        35                  40                  45              
Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asp Arg Val Thr
    50                  55                  60                  
Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp
65                  70                  75                  80  
Lys Trp Ser Ile Asp Pro Arg Val Ile Ile Leu Val Asn Thr Pro Thr
                85                  90                  95      
Gln Tyr Ser Ile Met Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro
            100                 105                 110         
Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val
        115                 120                 125             
His Leu Ile Val Gln Val Pro Pro Gln Ile Met Asn Ile Ser Ser Asp
    130                 135                 140                 
Ile Thr Val Asn Glu Gly Ser Ser Val Thr Leu Leu Cys Leu Ala Ile
145                 150                 155                 160 
Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Leu Ser Val Lys Glu
                165                 170                 175     
Gly Gln Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Ser Asp Ile
            180                 185                 190         
Lys Arg Asp Gln Ser Gly Glu Tyr Glu Cys Ser Ala Leu Asn Asp Val
        195                 200                 205             
Ala Ala Pro Asp Val Arg Lys Val Lys Ile Thr Val Asn Tyr Pro Pro
    210                 215                 220                 
Tyr Ile Ser Lys Ala Lys Asn Thr Gly Val Ser Val Gly Gln Lys Gly
225                 230                 235                 240 
Ile Leu Ser Cys Glu Ala Ser Ala Val Pro Met Ala Glu Phe Gln Trp
                245                 250                 255     
Phe Lys Glu Glu Thr Arg Leu Ala Thr Gly Leu Asp Gly Met Arg Ile
            260                 265                 270         
Glu Asn Lys Gly Arg Met Ser Thr Leu Thr Phe Phe Asn Val Ser Glu
        275                 280                 285             
Lys Asp Tyr Gly Asn Tyr Thr Cys Val Ala Thr Asn Lys Leu Gly Asn
    290                 295                 300                 
Thr Asn Ala Ser Ile Thr Leu Tyr Gly Pro Gly Ala Val Ile Asp Gly
305                 310                 315                 320 
Val Asn Ser Ala Ser Arg Ala Leu Ala Cys Leu Trp Leu Ser Gly Thr
                325                 330                 335     
Leu Leu Ala His Phe Phe Ile Lys Phe
            340                 345 


<210> 8791
<211> 446
<212> PRT
<213> Homo sapiens

<400> 8791
Gly Gly Arg Arg Pro Gly Arg Asp Pro Gly Arg Ala Leu Arg Ser Arg
 1               5                  10                  15      
Pro Val Ala Cys Ala Leu Pro Pro Ala Ala Ser Pro Ala Arg Gly Pro
            20                  25                  30          
Ser Ala Ala Gly Pro Arg Leu Ala Gly Cys Gly Ser Gly Leu Lys Met
        35                  40                  45              
Asp Glu Asp Gly Gly Gly Glu Gly Gly Gly Val Pro Glu Asp Leu Ser
    50                  55                  60                  
Leu Glu Glu Arg Glu Glu Leu Leu Asp Ile Arg Arg Arg Lys Lys Glu
65                  70                  75                  80  
Leu Ile Asp Asp Ile Glu Arg Leu Lys Tyr Glu Ile Ala Glu Val Met
                85                  90                  95      
Thr Glu Ile Asp Asn Leu Thr Ser Val Glu Glu Ser Lys Thr Thr Gln
            100                 105                 110         
Arg Asn Lys Gln Ile Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro
        115                 120                 125             
Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Gln Ser Ser
    130                 135                 140                 
Pro Glu Asp Val Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys
145                 150                 155                 160 
Thr Val Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile Lys
                165                 170                 175     
Val Leu Gln Ala Phe Val Glu Leu His Glu Phe Ala Asp Leu Asn Leu
            180                 185                 190         
Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu
        195                 200                 205             
Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Ser Arg Tyr Cys
    210                 215                 220                 
Leu Cys Asn Pro Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu
225                 230                 235                 240 
Ser Phe Ala Ile Ile Met Leu Asn Thr Ser Leu His Asn His Asn Val
                245                 250                 255     
Arg Asp Lys Pro Thr Ala Glu Arg Phe Ile Ala Met Asn Arg Gly Ile
            260                 265                 270         
Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu
        275                 280                 285             
Ser Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp
    290                 295                 300                 
Leu Thr His Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys
305                 310                 315                 320 
Leu Gly Gly Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr
                325                 330                 335     
Asp Asn Cys Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg
            340                 345                 350         
Gly Ile Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Pro
        355                 360                 365             
Arg Lys Pro Asn Cys Phe Glu Leu Tyr Asn Pro Ser His Lys Gly Gln
    370                 375                 380                 
Val Ile Lys Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly
385                 390                 395                 400 
Asn His Val Val Tyr Arg Ile Ser Ala Pro Ser Pro Glu Glu Lys Glu
                405                 410                 415     
Glu Trp Met Lys Ser Ile Lys Ala Ser Ile Ser Arg Asp Pro Phe Tyr
            420                 425                 430         
Asp Met Leu Ala Thr Arg Lys Arg Arg Ile Ala Asn Lys Lys
        435                 440                 445     


<210> 8792
<211> 400
<212> PRT
<213> Homo sapiens

<400> 8792
Met Asp Glu Asp Gly Gly Gly Glu Gly Gly Gly Val Pro Glu Asp Leu
 1               5                  10                  15      
Ser Leu Glu Glu Arg Glu Glu Leu Leu Asp Ile Arg Arg Arg Lys Lys
            20                  25                  30          
Glu Leu Ile Asp Asp Ile Glu Arg Leu Lys Tyr Glu Ile Ala Glu Val
        35                  40                  45              
Met Thr Glu Ile Asp Asn Leu Thr Ser Val Glu Glu Ser Lys Thr Thr
    50                  55                  60                  
Gln Arg Asn Lys Gln Ile Ala Met Gly Arg Lys Lys Phe Asn Met Asp
65                  70                  75                  80  
Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Gln Ser
                85                  90                  95      
Ser Pro Glu Asp Val Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn
            100                 105                 110         
Lys Thr Val Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile
        115                 120                 125             
Lys Val Leu Gln Ala Phe Val Glu Leu His Glu Phe Ala Asp Leu Asn
    130                 135                 140                 
Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly
145                 150                 155                 160 
Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Ser Arg Tyr
                165                 170                 175     
Cys Leu Cys Asn Pro Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val
            180                 185                 190         
Leu Ser Phe Ala Ile Ile Met Leu Asn Thr Ser Leu His Asn His Asn
        195                 200                 205             
Val Arg Asp Lys Pro Thr Ala Glu Arg Phe Ile Ala Met Asn Arg Gly
    210                 215                 220                 
Ile Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr
225                 230                 235                 240 
Glu Ser Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn
                245                 250                 255     
Asp Leu Thr His Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu
            260                 265                 270         
Lys Leu Gly Gly Gly Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile
        275                 280                 285             
Leu Thr Asp Asn Cys Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu
    290                 295                 300                 
Pro Arg Gly Ile Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu
305                 310                 315                 320 
Asp Pro Arg Lys Pro Asn Cys Phe Glu Leu Tyr Asn Pro Ser His Lys
                325                 330                 335     
Gly Gln Val Ile Lys Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val
            340                 345                 350         
Glu Gly Asn His Val Val Tyr Arg Ile Ser Ala Pro Ser Pro Glu Glu
        355                 360                 365             
Lys Glu Glu Trp Met Lys Ser Ile Lys Ala Ser Ile Ser Arg Asp Pro
    370                 375                 380                 
Phe Tyr Asp Met Leu Ala Thr Arg Lys Arg Arg Ile Ala Asn Lys Lys
385                 390                 395                 400 


<210> 8793
<211> 4834
<212> PRT
<213> Homo sapiens

<400> 8793
Met Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Cys Ser Ser Ala
 1               5                  10                  15      
Ala Gly Ala Gly Ala Ala Gly Val Ser Glu Trp Leu Val Leu Arg Asp
            20                  25                  30          
Gly Cys Met His Cys Asp Ala Asp Gly Leu His Ser Leu Ser Tyr His
        35                  40                  45              
Pro Ala Leu Asn Ala Ile Leu Ala Val Thr Ser Arg Gly Thr Ile Lys
    50                  55                  60                  
Val Ile Asp Gly Thr Ser Gly Ala Thr Leu Gln Ala Ser Ala Leu Ser
65                  70                  75                  80  
Ala Lys Pro Gly Gly Gln Val Lys Cys Gln Tyr Ile Ser Ala Val Asp
                85                  90                  95      
Lys Val Ile Phe Val Asp Asp Tyr Ala Val Gly Cys Arg Lys Asp Leu
            100                 105                 110         
Asn Gly Ile Leu Leu Leu Asp Thr Ala Leu Gln Thr Pro Val Ser Lys
        115                 120                 125             
Gln Asp Asp Val Val Gln Leu Glu Leu Pro Val Thr Glu Ala Gln Gln
    130                 135                 140                 
Leu Leu Ser Ala Cys Leu Glu Lys Val Asp Ile Ser Ser Thr Glu Gly
145                 150                 155                 160 
Tyr Asp Leu Phe Ile Thr Gln Leu Lys Asp Gly Leu Lys Asn Thr Ser
                165                 170                 175     
His Glu Thr Ala Ala Asn His Lys Val Ala Lys Trp Ala Thr Val Thr
            180                 185                 190         
Phe His Leu Pro His His Val Leu Lys Ser Ile Ala Ser Ala Ile Val
        195                 200                 205             
Asn Glu Leu Lys Lys Ile Asn Gln Asn Val Ala Ala Leu Pro Val Ala
    210                 215                 220                 
Ser Ser Val Met Asp Arg Leu Ser Tyr Leu Leu Pro Ser Ala Arg Pro
225                 230                 235                 240 
Glu Leu Gly Val Gly Pro Gly Arg Ser Val Asp Arg Ser Leu Met Tyr
                245                 250                 255     
Ser Glu Ala Asn Arg Arg Glu Thr Phe Thr Ser Trp Pro His Val Gly
            260                 265                 270         
Tyr Arg Trp Ala Gln Pro Asp Pro Met Ala Gln Ala Gly Phe Tyr His
        275                 280                 285             
Gln Pro Ala Ser Ser Gly Asp Asp Arg Ala Met Cys Phe Thr Cys Ser
    290                 295                 300                 
Val Cys Leu Val Cys Trp Glu Pro Thr Asp Glu Pro Trp Ser Glu His
305                 310                 315                 320 
Glu Arg His Ser Pro Asn Cys Pro Phe Val Lys Gly Glu His Thr Gln
                325                 330                 335     
Asn Val Pro Leu Ser Val Thr Leu Ala Thr Ser Pro Ala Gln Phe Pro
            340                 345                 350         
Cys Thr Asp Gly Thr Asp Arg Ile Ser Cys Phe Gly Ser Gly Ser Cys
        355                 360                 365             
Pro His Phe Leu Ala Ala Ala Thr Lys Arg Gly Lys Ile Cys Ile Trp
    370                 375                 380                 
Asp Val Ser Lys Leu Met Lys Val His Leu Lys Phe Glu Ile Asn Ala
385                 390                 395                 400 
Tyr Asp Pro Ala Ile Val Gln Gln Leu Ile Leu Ser Gly Asp Pro Ser
                405                 410                 415     
Ser Gly Val Asp Ser Arg Arg Pro Thr Leu Ala Trp Leu Glu Asp Ser
            420                 425                 430         
Ser Ser Cys Ser Asp Ile Pro Lys Leu Glu Gly Asp Ser Asp Asp Leu
        435                 440                 445             
Leu Glu Asp Ser Asp Ser Glu Glu His Ser Arg Ser Asp Ser Val Thr
    450                 455                 460                 
Gly His Thr Ser Gln Lys Glu Ala Met Glu Val Ser Leu Asp Ile Thr
465                 470                 475                 480 
Ala Leu Ser Ile Leu Gln Gln Pro Glu Lys Leu Gln Trp Glu Ile Val
                485                 490                 495     
Ala Asn Val Leu Glu Asp Thr Val Lys Asp Leu Glu Glu Leu Gly Ala
            500                 505                 510         
Asn Pro Cys Leu Thr Asn Ser Lys Ser Glu Lys Thr Lys Glu Lys His
        515                 520                 525             
Gln Glu Gln His Asn Ile Pro Phe Pro Cys Leu Leu Ala Gly Gly Leu
    530                 535                 540                 
Leu Thr Tyr Lys Ser Pro Ala Thr Ser Pro Ile Ser Ser Asn Ser His
545                 550                 555                 560 
Arg Ser Leu Asp Gly Leu Ser Arg Thr Gln Gly Glu Ser Ile Ser Glu
                565                 570                 575     
Gln Gly Ser Thr Asp Asn Glu Ser Cys Thr Asn Ser Glu Leu Asn Ser
            580                 585                 590         
Pro Leu Val Arg Arg Thr Leu Pro Val Leu Leu Leu Tyr Ser Ile Lys
        595                 600                 605             
Glu Ser Asp Glu Lys Ala Gly Lys Ile Phe Ser Gln Met Asn Asn Ile
    610                 615                 620                 
Met Ser Lys Ser Leu His Asp Asp Gly Phe Thr Val Pro Gln Ile Ile
625                 630                 635                 640 
Glu Met Glu Leu Asp Ser Gln Glu Gln Leu Leu Leu Gln Asp Pro Pro
                645                 650                 655     
Val Thr Tyr Ile Gln Gln Phe Ala Asp Ala Ala Ala Asn Leu Thr Ser
            660                 665                 670         
Pro Asp Ser Glu Lys Trp Asn Ser Val Phe Pro Lys Pro Gly Thr Leu
        675                 680                 685             
Val Gln Cys Leu Arg Leu Pro Lys Phe Ala Glu Glu Glu Asn Leu Cys
    690                 695                 700                 
Ile Asp Ser Ile Thr Pro Cys Ala Asp Gly Ile His Leu Leu Val Gly
705                 710                 715                 720 
Leu Arg Thr Cys Pro Val Glu Ser Leu Ser Ala Ile Asn Gln Val Glu
                725                 730                 735     
Ala Leu Asn Asn Leu Asn Lys Leu Asn Ser Ala Leu Cys Asn Arg Arg
            740                 745                 750         
Lys Gly Glu Leu Glu Ser Asn Leu Ala Val Val Asn Gly Ala Asn Ile
        755                 760                 765             
Ser Val Ile Gln His Glu Ser Pro Ala Asp Val Gln Thr Pro Leu Ile
    770                 775                 780                 
Ile Gln Pro Glu Gln Arg Asn Val Ser Gly Gly Tyr Leu Val Leu Tyr
785                 790                 795                 800 
Lys Met Asn Tyr Ala Thr Arg Ile Val Thr Leu Glu Glu Glu Pro Ile
                805                 810                 815     
Lys Ile Gln His Ile Lys Asp Pro Gln Asp Thr Ile Thr Ser Leu Ile
            820                 825                 830         
Leu Leu Pro Pro Asp Ile Leu Asp Asn Arg Glu Asp Asp Cys Glu Glu
        835                 840                 845             
Pro Ile Glu Asp Met Gln Leu Thr Ser Lys Asn Gly Phe Glu Arg Glu
    850                 855                 860                 
Lys Thr Ser Asp Ile Ser Thr Leu Gly His Leu Val Ile Thr Thr Gln
865                 870                 875                 880 
Gly Gly Tyr Val Lys Ile Leu Asp Leu Ser Asn Phe Glu Ile Leu Ala
                885                 890                 895     
Lys Val Glu Pro Pro Lys Lys Glu Gly Thr Glu Glu Gln Asp Thr Phe
            900                 905                 910         
Val Ser Val Ile Tyr Cys Ser Gly Thr Asp Arg Leu Cys Ala Cys Thr
        915                 920                 925             
Lys Gly Gly Glu Leu His Phe Leu Gln Ile Gly Gly Thr Cys Asp Asp
    930                 935                 940                 
Ile Asp Glu Ala Asp Ile Leu Val Asp Gly Ser Leu Ser Lys Gly Ile
945                 950                 955                 960 
Glu Pro Ser Ser Glu Gly Ser Lys Pro Leu Ser Asn Pro Ser Ser Pro
                965                 970                 975     
Gly Ile Ser Gly Val Asp Leu Leu Val Asp Gln Pro Phe Thr Leu Glu
            980                 985                 990         
Ile Leu Thr Ser Leu Val Glu Leu Thr Arg Phe Glu Thr Leu Thr Pro
        995                 1000                1005            
Arg Phe Ser Ala Thr Val Pro Pro Cys Trp Val Glu Val Gln Gln Glu
    1010                1015                1020                
Gln Gln Gln Arg Arg His Pro Gln His Leu His Gln Gln His His Gly
1025                1030                1035                1040
Asp Ala Ala Gln His Thr Arg Thr Trp Lys Leu Gln Thr Asp Ser Asn
                1045                1050                1055    
Ser Trp Asp Glu His Val Phe Glu Leu Val Leu Pro Lys Ala Cys Met
            1060                1065                1070        
Val Gly His Val Asp Phe Lys Phe Val Leu Asn Ser Asn Ile Thr Asn
        1075                1080                1085            
Ile Pro Gln Ile Gln Val Thr Leu Leu Lys Asn Lys Ala Pro Gly Leu
    1090                1095                1100                
Gly Lys Val Asn Ala Leu Asn Ile Glu Val Glu Gln Asn Gly Lys Pro
1105                1110                1115                1120
Ser Leu Val Asp Leu Asn Glu Glu Met Gln His Met Asp Val Glu Glu
                1125                1130                1135    
Ser Gln Cys Leu Arg Leu Cys Pro Phe Leu Glu Asp His Lys Glu Asp
            1140                1145                1150        
Ile Leu Cys Gly Pro Val Trp Leu Ala Ser Gly Leu Asp Leu Ser Gly
        1155                1160                1165            
His Ala Gly Met Leu Thr Leu Thr Ser Pro Lys Leu Val Lys Gly Met
    1170                1175                1180                
Ala Gly Gly Lys Tyr Arg Ser Phe Leu Ile His Val Lys Ala Val Asn
1185                1190                1195                1200
Glu Arg Gly Thr Glu Glu Ile Cys Asn Gly Gly Met Arg Pro Val Val
                1205                1210                1215    
Arg Leu Pro Ser Leu Lys His Gln Ser Asn Lys Gly Tyr Ser Leu Ala
            1220                1225                1230        
Ser Leu Leu Ala Lys Val Ala Ala Gly Lys Glu Lys Ser Ser Asn Val
        1235                1240                1245            
Lys Asn Glu Asn Thr Ser Gly Thr Arg Lys Ser Glu Asn Leu Arg Gly
    1250                1255                1260                
Cys Asp Leu Leu Gln Glu Val Ser Val Thr Ile Arg Arg Phe Lys Lys
1265                1270                1275                1280
Thr Ser Ile Ser Lys Glu Arg Val Gln Arg Cys Ala Met Leu Gln Phe
                1285                1290                1295    
Ser Glu Phe His Glu Lys Leu Val Asn Thr Leu Cys Arg Lys Thr Asp
            1300                1305                1310        
Asp Gly Gln Ile Thr Glu His Ala Gln Ser Leu Val Leu Asp Thr Leu
        1315                1320                1325            
Cys Trp Leu Ala Gly Val His Ser Asn Gly Pro Gly Ser Ser Lys Glu
    1330                1335                1340                
Gly Asn Glu Asn Leu Leu Ser Lys Thr Arg Lys Phe Leu Ser Asp Ile
1345                1350                1355                1360
Val Arg Val Cys Phe Phe Glu Ala Gly Arg Ser Ile Ala His Lys Cys
                1365                1370                1375    
Ala Arg Phe Leu Ala Leu Cys Ile Ser Asn Gly Lys Cys Asp Pro Cys
            1380                1385                1390        
Gln Pro Ala Phe Gly Pro Val Leu Leu Lys Ala Leu Leu Asp Asn Met
        1395                1400                1405            
Ser Phe Leu Pro Ala Ala Thr Thr Gly Gly Ser Val Tyr Trp Tyr Phe
    1410                1415                1420                
Val Leu Leu Asn Tyr Val Lys Asp Glu Asp Leu Ala Gly Cys Ser Thr
1425                1430                1435                1440
Ala Cys Ala Ser Leu Leu Thr Ala Val Ser Arg Gln Leu Gln Asp Arg
                1445                1450                1455    
Leu Thr Pro Met Glu Ala Leu Leu Gln Thr Arg Tyr Gly Leu Tyr Ser
            1460                1465                1470        
Ser Pro Phe Asp Pro Val Leu Phe Asp Leu Glu Met Ser Gly Ser Ser
        1475                1480                1485            
Cys Lys Asn Val Tyr Asn Ser Ser Ile Gly Val Gln Ser Asp Glu Ile
    1490                1495                1500                
Asp Leu Ser Asp Val Leu Ser Gly Asn Gly Lys Val Ser Ser Cys Thr
1505                1510                1515                1520
Ala Ala Glu Gly Ser Phe Thr Ser Leu Thr Gly Leu Leu Glu Val Glu
                1525                1530                1535    
Pro Leu His Phe Thr Cys Val Ser Thr Ser Asp Gly Thr Arg Ile Glu
            1540                1545                1550        
Arg Asp Asp Ala Met Ser Ser Phe Gly Val Thr Pro Ala Val Gly Gly
        1555                1560                1565            
Leu Ser Ser Gly Thr Val Gly Glu Ala Ser Thr Ala Leu Ser Ser Ala
    1570                1575                1580                
Ala Gln Val Ala Leu Gln Ser Leu Ser His Ala Met Ala Ser Ala Glu
1585                1590                1595                1600
Gln Gln Leu Gln Val Leu Gln Glu Lys Gln Gln Gln Leu Leu Lys Leu
                1605                1610                1615    
Gln Gln Gln Lys Ala Lys Leu Glu Ala Lys Leu His Gln Thr Thr Ala
            1620                1625                1630        
Ala Ala Ala Ala Ala Ala Ser Ala Val Gly Pro Val His Asn Ser Val
        1635                1640                1645            
Pro Ser Asn Pro Val Ala Ala Pro Gly Phe Phe Ile His Pro Ser Asp
    1650                1655                1660                
Val Ile Pro Pro Thr Pro Lys Thr Thr Pro Leu Phe Met Thr Pro Pro
1665                1670                1675                1680
Leu Thr Pro Pro Asn Glu Ala Val Ser Val Val Ile Asn Ala Glu Leu
                1685                1690                1695    
Ala Gln Leu Phe Pro Gly Ser Val Ile Asp Pro Pro Ala Val Asn Leu
            1700                1705                1710        
Ala Ala His Asn Lys Asn Ser Asn Lys Ser Arg Met Asn Pro Leu Gly
        1715                1720                1725            
Ser Gly Leu Ala Leu Ala Ile Ser His Ala Ser His Phe Leu Gln Pro
    1730                1735                1740                
Pro Pro His Gln Ser Ile Ile Ile Glu Arg Met His Ser Gly Ala Arg
1745                1750                1755                1760
Arg Phe Val Thr Leu Asp Phe Gly Arg Pro Ile Leu Leu Thr Asp Val
                1765                1770                1775    
Leu Ile Pro Thr Cys Gly Asp Leu Ala Ser Leu Ser Ile Asp Ile Trp
            1780                1785                1790        
Thr Leu Gly Glu Glu Val Asp Gly Arg Arg Leu Val Val Ala Thr Asp
        1795                1800                1805            
Ile Ser Thr His Ser Leu Ile Leu His Asp Leu Ile Pro Pro Pro Val
    1810                1815                1820                
Cys Arg Phe Met Lys Ile Thr Val Ile Gly Arg Tyr Gly Ser Thr Asn
1825                1830                1835                1840
Ala Arg Ala Lys Ile Pro Leu Gly Phe Tyr Tyr Gly His Thr Tyr Ile
                1845                1850                1855    
Leu Pro Trp Glu Ser Glu Leu Lys Leu Met His Asp Pro Leu Lys Gly
            1860                1865                1870        
Glu Gly Glu Ser Ala Asn Gln Pro Glu Ile Asp Gln His Leu Ala Met
        1875                1880                1885            
Met Val Ala Leu Gln Glu Asp Ile Gln Cys Arg Tyr Asn Leu Ala Cys
    1890                1895                1900                
His Arg Leu Glu Thr Leu Leu Gln Ser Ile Asp Leu Pro Pro Leu Asn
1905                1910                1915                1920
Ser Ala Asn Asn Ala Gln Tyr Phe Leu Arg Lys Pro Asp Lys Ala Val
                1925                1930                1935    
Glu Glu Asp Ser Arg Val Phe Ser Ala Tyr Gln Asp Cys Ile Gln Leu
            1940                1945                1950        
Gln Leu Gln Leu Asn Leu Ala His Asn Ala Val Gln Arg Leu Lys Val
        1955                1960                1965            
Ala Leu Gly Ala Ser Arg Lys Met Leu Ser Glu Thr Ser Asn Pro Glu
    1970                1975                1980                
Asp Leu Ile Gln Thr Ser Ser Thr Glu Gln Leu Arg Thr Ile Ile Arg
1985                1990                1995                2000
Tyr Leu Leu Asp Thr Leu Leu Ser Leu Leu His Ala Ser Asn Gly His
                2005                2010                2015    
Ser Val Pro Ala Val Leu Gln Ser Thr Phe His Ala Gln Ala Cys Glu
            2020                2025                2030        
Glu Leu Phe Lys His Leu Cys Ile Ser Gly Thr Pro Lys Ile Arg Leu
        2035                2040                2045            
His Thr Gly Leu Leu Leu Val Gln Leu Cys Gly Gly Glu Arg Trp Trp
    2050                2055                2060                
Gly Gln Phe Leu Ser Asn Val Leu Gln Glu Leu Tyr Asn Ser Glu Gln
2065                2070                2075                2080
Leu Leu Ile Phe Pro Gln Asp Arg Val Phe Met Leu Leu Ser Cys Ile
                2085                2090                2095    
Gly Gln Arg Ser Leu Ser Asn Ser Gly Val Leu Glu Ser Leu Leu Asn
            2100                2105                2110        
Leu Leu Asp Asn Leu Leu Ser Pro Leu Gln Pro Gln Leu Pro Met His
        2115                2120                2125            
Arg Arg Thr Glu Gly Val Leu Asp Ile Pro Met Ile Ser Trp Val Val
    2130                2135                2140                
Met Leu Val Ser Arg Leu Leu Asp Tyr Val Ala Thr Val Glu Asp Glu
2145                2150                2155                2160
Ala Ala Ala Ala Lys Lys Pro Leu Asn Gly Asn Gln Trp Ser Phe Ile
                2165                2170                2175    
Asn Asn Asn Leu His Thr Gln Ser Leu Asn Arg Ser Ser Lys Gly Ser
            2180                2185                2190        
Ser Ser Leu Asp Arg Leu Tyr Ser Arg Lys Ile Arg Lys Gln Leu Val
        2195                2200                2205            
His His Lys Gln Gln Leu Asn Leu Leu Lys Ala Lys Gln Lys Ala Leu
    2210                2215                2220                
Val Glu Gln Met Glu Lys Glu Lys Ile Gln Ser Asn Lys Gly Ser Ser
2225                2230                2235                2240
Tyr Lys Leu Leu Val Glu Gln Ala Lys Leu Lys Gln Ala Thr Ser Lys
                2245                2250                2255    
His Phe Lys Asp Leu Ile Arg Leu Arg Arg Thr Ala Glu Trp Ser Arg
            2260                2265                2270        
Ser Asn Leu Asp Thr Glu Val Thr Thr Ala Lys Glu Ser Pro Glu Ile
        2275                2280                2285            
Glu Pro Leu Pro Phe Thr Leu Ala His Glu Arg Cys Ile Ser Val Val
    2290                2295                2300                
Gln Lys Leu Val Leu Phe Leu Leu Ser Met Asp Phe Thr Cys His Ala
2305                2310                2315                2320
Asp Leu Leu Leu Phe Val Cys Lys Val Leu Ala Arg Ile Ala Asn Ala
                2325                2330                2335    
Thr Arg Pro Thr Ile His Leu Cys Glu Ile Val Asn Glu Pro Gln Leu
            2340                2345                2350        
Glu Arg Leu Leu Leu Leu Leu Val Gly Thr Asp Phe Asn Arg Gly Asp
        2355                2360                2365            
Ile Ser Trp Gly Gly Ala Trp Ala Gln Tyr Ser Leu Thr Cys Met Leu
    2370                2375                2380                
Gln Asp Ile Leu Ala Gly Glu Leu Leu Ala Pro Val Ala Ala Glu Ala
2385                2390                2395                2400
Met Glu Glu Gly Thr Val Gly Asp Asp Val Gly Ala Thr Ala Gly Asp
                2405                2410                2415    
Ser Asp Asp Ser Leu Gln Gln Ser Ser Val Gln Leu Leu Glu Thr Ile
            2420                2425                2430        
Asp Glu Pro Leu Thr His Asp Ile Thr Gly Ala Pro Pro Leu Ser Ser
        2435                2440                2445            
Leu Glu Lys Asp Lys Glu Ile Asp Leu Glu Leu Leu Gln Asp Leu Met
    2450                2455                2460                
Glu Val Asp Ile Asp Pro Leu Asp Ile Asp Leu Glu Lys Asp Pro Leu
2465                2470                2475                2480
Ala Ala Lys Val Phe Lys Pro Ile Ser Ser Thr Trp Tyr Asp Tyr Trp
                2485                2490                2495    
Gly Ala Asp Tyr Gly Thr Tyr Asn Tyr Asn Pro Tyr Ile Gly Gly Leu
            2500                2505                2510        
Gly Ile Pro Val Ala Lys Pro Pro Ala Asn Thr Glu Lys Asn Gly Ser
        2515                2520                2525            
Gln Thr Val Ser Val Ser Val Ser Gln Ala Leu Asp Ala Arg Leu Glu
    2530                2535                2540                
Val Gly Leu Glu Gln Gln Ala Glu Leu Met Leu Lys Met Met Ser Thr
2545                2550                2555                2560
Leu Glu Ala Asp Ser Ile Leu Gln Ala Leu Thr Asn Thr Ser Pro Thr
                2565                2570                2575    
Leu Ser Gln Ser Pro Thr Gly Thr Asp Asp Ser Leu Leu Gly Gly Leu
            2580                2585                2590        
Gln Ala Ala Asn Gln Thr Ser Gln Leu Ile Ile Gln Leu Ser Ser Val
        2595                2600                2605            
Pro Met Leu Asn Val Cys Phe Asn Lys Leu Phe Ser Met Leu Gln Val
    2610                2615                2620                
His His Val Gln Leu Glu Ser Leu Leu Gln Leu Trp Leu Thr Leu Ser
2625                2630                2635                2640
Leu Asn Ser Ser Ser Thr Gly Asn Lys Glu Asn Gly Ala Asp Ile Phe
                2645                2650                2655    
Leu Tyr Asn Ala Asn Arg Ile Pro Val Ile Ser Leu Asn Gln Ala Ser
            2660                2665                2670        
Ile Thr Ser Phe Leu Thr Val Leu Ala Trp Tyr Pro Asn Thr Leu Leu
        2675                2680                2685            
Arg Thr Trp Cys Leu Val Leu His Ser Leu Thr Leu Met Thr Asn Met
    2690                2695                2700                
Gln Leu Asn Ser Gly Ser Ser Ser Ala Ile Gly Thr Gln Glu Ser Thr
2705                2710                2715                2720
Ala His Leu Leu Val Ser Asp Pro Asn Leu Ile His Val Leu Val Lys
                2725                2730                2735    
Phe Leu Ser Gly Thr Ser Pro His Gly Thr Asn Gln His Ser Pro Gln
            2740                2745                2750        
Val Gly Pro Thr Ala Thr Gln Ala Met Gln Glu Phe Leu Thr Arg Leu
        2755                2760                2765            
Gln Val His Leu Ser Ser Thr Cys Pro Gln Ile Phe Ser Glu Phe Leu
    2770                2775                2780                
Leu Lys Leu Ile His Ile Leu Ser Thr Glu Arg Gly Ala Phe Gln Thr
2785                2790                2795                2800
Gly Gln Gly Pro Leu Asp Ala Gln Val Lys Leu Leu Glu Phe Thr Leu
                2805                2810                2815    
Glu Gln Asn Phe Glu Val Val Ser Val Ser Thr Ile Ser Ala Val Ile
            2820                2825                2830        
Glu Ser Val Thr Phe Leu Val His His Tyr Ile Thr Cys Ser Asp Lys
        2835                2840                2845            
Val Met Ser Arg Ser Gly Ser Asp Ser Ser Val Gly Ala Arg Ala Cys
    2850                2855                2860                
Phe Gly Gly Leu Phe Ala Asn Leu Ile Arg Pro Gly Asp Ala Lys Ala
2865                2870                2875                2880
Val Cys Gly Glu Met Thr Arg Asp Gln Leu Met Phe Asp Leu Leu Lys
                2885                2890                2895    
Leu Val Asn Ile Leu Val Gln Leu Pro Leu Ser Gly Asn Arg Glu Tyr
            2900                2905                2910        
Ser Ala Arg Val Ser Val Thr Thr Asn Thr Thr Asp Ser Val Ser Asp
        2915                2920                2925            
Glu Glu Lys Val Ser Gly Gly Lys Asp Gly Asn Gly Ser Ser Thr Ser
    2930                2935                2940                
Val Gln Gly Ser Pro Ala Tyr Val Ala Asp Leu Val Leu Ala Asn Gln
2945                2950                2955                2960
Gln Ile Met Ser Gln Ile Leu Ser Ala Leu Gly Leu Cys Asn Ser Ser
                2965                2970                2975    
Ala Met Ala Met Ile Ile Gly Ala Ser Gly Leu His Leu Thr Lys His
            2980                2985                2990        
Glu Asn Phe His Gly Gly Leu Asp Ala Ile Ser Val Gly Asp Gly Leu
        2995                3000                3005            
Phe Thr Ile Leu Thr Thr Leu Ser Lys Lys Ala Ser Thr Val His Met
    3010                3015                3020                
Met Leu Gln Pro Ile Leu Thr Tyr Met Ala Cys Gly Tyr Met Gly Arg
3025                3030                3035                3040
Gln Gly Ser Leu Ala Thr Cys Gln Leu Ser Glu Pro Leu Leu Trp Phe
                3045                3050                3055    
Ile Leu Arg Val Leu Asp Thr Ser Asp Ala Leu Lys Ala Phe His Asp
            3060                3065                3070        
Met Gly Gly Val Gln Leu Ile Cys Asn Asn Met Val Thr Ser Thr Arg
        3075                3080                3085            
Ala Ile Val Asn Thr Ala Arg Ser Met Val Ser Thr Ile Met Lys Phe
    3090                3095                3100                
Leu Asp Ser Gly Pro Asn Lys Ala Val Asp Ser Thr Leu Lys Thr Arg
3105                3110                3115                3120
Ile Leu Ala Ser Glu Pro Asp Asn Ala Glu Gly Ile His Asn Phe Ala
                3125                3130                3135    
Pro Leu Gly Thr Ile Thr Ser Ser Ser Pro Thr Ala Gln Pro Ala Glu
            3140                3145                3150        
Val Leu Leu Gln Ala Thr Pro Pro His Arg Arg Ala Arg Ser Ala Ala
        3155                3160                3165            
Trp Ser Tyr Ile Phe Leu Pro Glu Glu Ala Trp Cys Asp Leu Thr Ile
    3170                3175                3180                
His Leu Pro Ala Ala Val Leu Leu Lys Glu Ile His Ile Gln Pro His
3185                3190                3195                3200
Leu Ala Ser Leu Ala Thr Cys Pro Ser Ser Val Ser Val Glu Val Ser
                3205                3210                3215    
Ala Asp Gly Val Asn Met Leu Pro Leu Ser Thr Pro Val Val Thr Ser
            3220                3225                3230        
Gly Leu Thr Tyr Ile Lys Ile Gln Leu Val Lys Ala Glu Val Ala Ser
        3235                3240                3245            
Ala Val Cys Leu Arg Leu His Arg Pro Arg Asp Ala Ser Thr Leu Gly
    3250                3255                3260                
Leu Ser Gln Ile Lys Leu Leu Gly Leu Thr Ala Phe Gly Thr Thr Ser
3265                3270                3275                3280
Ser Ala Thr Val Asn Asn Pro Phe Leu Pro Ser Glu Asp Gln Val Ser
                3285                3290                3295    
Lys Thr Ser Ile Gly Trp Leu Arg Leu Leu His His Cys Leu Thr His
            3300                3305                3310        
Ile Ser Asp Leu Glu Gly Met Met Ala Ser Ala Ala Ala Pro Thr Ala
        3315                3320                3325            
Asn Leu Leu Gln Thr Cys Ala Ala Leu Leu Met Ser Pro Tyr Cys Gly
    3330                3335                3340                
Met His Ser Pro Asn Ile Glu Val Val Leu Val Lys Ile Gly Leu Gln
3345                3350                3355                3360
Ser Thr Arg Ile Gly Leu Lys Leu Ile Asp Ile Leu Leu Arg Asn Cys
                3365                3370                3375    
Ala Ala Ser Gly Ser Asp Pro Thr Asp Leu Asn Ser Pro Leu Leu Phe
            3380                3385                3390        
Gly Arg Leu Asn Gly Leu Ser Ser Asp Ser Thr Ile Asp Ile Leu Tyr
        3395                3400                3405            
Gln Leu Gly Thr Thr Gln Asp Pro Gly Thr Lys Asp Arg Ile Gln Ala
    3410                3415                3420                
Leu Leu Lys Trp Val Ser Asp Ser Ala Arg Val Ala Ala Met Lys Arg
3425                3430                3435                3440
Ser Gly Arg Met Asn Tyr Met Cys Pro Asn Ser Ser Thr Val Glu Tyr
                3445                3450                3455    
Gly Leu Leu Met Pro Ser Pro Ser His Leu His Cys Val Ala Ala Ile
            3460                3465                3470        
Leu Trp His Ser Tyr Glu Leu Leu Val Glu Tyr Asp Leu Pro Ala Leu
        3475                3480                3485            
Leu Asp Gln Glu Leu Phe Glu Leu Leu Phe Asn Trp Ser Met Ser Leu
    3490                3495                3500                
Pro Cys Asn Met Val Leu Lys Lys Ala Val Asp Ser Leu Leu Cys Ser
3505                3510                3515                3520
Met Cys His Val His Pro Asn Tyr Phe Ser Leu Leu Met Gly Trp Met
                3525                3530                3535    
Gly Ile Thr Pro Pro Pro Val Gln Cys His His Arg Leu Ser Met Thr
            3540                3545                3550        
Asp Asp Ser Lys Lys Gln Asp Leu Ser Ser Ser Leu Thr Asp Asp Ser
        3555                3560                3565            
Lys Asn Ala Gln Ala Pro Leu Ala Leu Thr Glu Ser His Leu Ala Thr
    3570                3575                3580                
Leu Ala Ser Ser Ser Gln Ser Pro Glu Ala Ile Lys Gln Leu Leu Asp
3585                3590                3595                3600
Ser Gly Leu Pro Ser Leu Leu Val Arg Ser Leu Ala Ser Phe Cys Phe
                3605                3610                3615    
Ser His Ile Ser Ser Ser Glu Ser Ile Ala Gln Ser Ile Asp Ile Ser
            3620                3625                3630        
Gln Asp Lys Leu Arg Arg His His Val Pro Gln Gln Cys Asn Lys Met
        3635                3640                3645            
Pro Ile Thr Ala Asp Leu Val Ala Pro Ile Leu Arg Phe Leu Thr Glu
    3650                3655                3660                
Val Gly Asn Ser His Ile Met Lys Asp Trp Leu Gly Gly Ser Glu Val
3665                3670                3675                3680
Asn Pro Leu Trp Thr Ala Leu Leu Phe Leu Leu Cys His Ser Gly Ser
                3685                3690                3695    
Thr Ser Gly Ser His Asn Leu Gly Ala Gln Gln Thr Ser Ala Arg Ser
            3700                3705                3710        
Ala Ser Leu Ser Ser Ala Ala Thr Thr Gly Leu Thr Thr Gln Gln Arg
        3715                3720                3725            
Thr Ala Ile Glu Asn Ala Thr Val Ala Phe Phe Leu Gln Cys Ile Ser
    3730                3735                3740                
Cys His Pro Asn Asn Gln Lys Leu Met Ala Gln Val Leu Cys Glu Leu
3745                3750                3755                3760
Phe Gln Thr Ser Pro Gln Arg Gly Asn Leu Pro Thr Ser Gly Asn Ile
                3765                3770                3775    
Ser Gly Phe Ile Arg Arg Leu Phe Leu Gln Leu Met Leu Glu Asp Glu
            3780                3785                3790        
Lys Val Thr Met Phe Leu Gln Ser Pro Cys Pro Leu Tyr Lys Gly Arg
        3795                3800                3805            
Ile Asn Ala Thr Ser His Val Ile Gln His Pro Met Tyr Gly Ala Gly
    3810                3815                3820                
His Lys Phe Arg Thr Leu His Leu Pro Val Ser Thr Thr Leu Ser Asp
3825                3830                3835                3840
Val Leu Asp Arg Val Ser Gly Lys Ser Asp Leu Asn Thr Pro Ser Ile
                3845                3850                3855    
Thr Ala Lys Leu Ile Ser Glu Gln Lys Asp Asp Lys Glu Lys Lys Asn
            3860                3865                3870        
His Glu Glu Lys Glu Lys Val Lys Ala Glu Asn Gly Phe Gln Asp Asn
        3875                3880                3885            
Tyr Ser Val Val Val Ala Ser Gly Leu Lys Ser Gln Ser Lys Arg Ala
    3890                3895                3900                
Val Ser Ala Thr Pro Pro Arg Pro Pro Ser Arg Arg Gly Arg Thr Ile
3905                3910                3915                3920
Pro Asp Lys Ile Gly Ser Thr Ser Gly Ala Glu Ala Ala Asn Lys Ile
                3925                3930                3935    
Ile Thr Val Pro Val Phe His Leu Phe His Lys Leu Leu Ala Gly Gln
            3940                3945                3950        
Pro Leu Pro Ala Glu Met Thr Leu Ala Gln Leu Leu Thr Leu Leu Tyr
        3955                3960                3965            
Asp Arg Lys Leu Pro Gln Gly Tyr Arg Ser Ile Asp Leu Thr Val Lys
    3970                3975                3980                
Leu Gly Ser Arg Val Ile Thr Asp Pro Ser Leu Ser Lys Thr Asp Ser
3985                3990                3995                4000
Tyr Lys Arg Leu His Pro Glu Lys Asp His Gly Asp Leu Leu Ala Ser
                4005                4010                4015    
Cys Pro Glu Asp Glu Ala Leu Thr Pro Gly Asp Glu Cys Met Asp Gly
            4020                4025                4030        
Ile Leu Asp Glu Ser Leu Leu Glu Thr Cys Pro Ile Gln Ser Pro Leu
        4035                4040                4045            
Gln Val Phe Ala Gly Met Gly Gly Leu Ala Leu Ile Ala Glu Arg Leu
    4050                4055                4060                
Pro Met Leu Tyr Pro Glu Val Ile Gln Gln Val Ser Ala Pro Val Val
4065                4070                4075                4080
Thr Ser Thr Thr Gln Glu Lys Pro Lys Asp Ser Asp Gln Phe Glu Trp
                4085                4090                4095    
Val Thr Ile Glu Gln Ser Gly Glu Leu Val Tyr Glu Ala Pro Glu Thr
            4100                4105                4110        
Val Ala Ala Glu Pro Pro Pro Ile Lys Ser Ala Val Gln Thr Met Ser
        4115                4120                4125            
Pro Ile Pro Ala His Ser Leu Ala Ala Phe Gly Leu Phe Leu Arg Leu
    4130                4135                4140                
Pro Gly Tyr Ala Glu Val Leu Leu Lys Glu Arg Lys His Ala Gln Cys
4145                4150                4155                4160
Leu Leu Arg Leu Val Leu Gly Val Thr Asp Asp Gly Glu Gly Ser His
                4165                4170                4175    
Ile Leu Gln Ser Pro Ser Ala Asn Val Leu Pro Thr Leu Pro Phe His
            4180                4185                4190        
Val Leu Arg Ser Leu Phe Ser Thr Thr Pro Leu Thr Thr Asp Asp Gly
        4195                4200                4205            
Val Leu Leu Arg Arg Met Ala Leu Glu Ile Gly Ala Leu His Leu Ile
    4210                4215                4220                
Leu Val Cys Leu Ser Ala Leu Ser His His Ser Pro Arg Val Pro Asn
4225                4230                4235                4240
Ser Ser Val Asn Gln Thr Glu Pro Gln Val Ser Ser Ser His Asn Pro
                4245                4250                4255    
Thr Ser Thr Glu Glu Gln Gln Leu Tyr Trp Ala Lys Gly Thr Gly Phe
            4260                4265                4270        
Gly Thr Gly Ser Thr Ala Ser Gly Trp Asp Val Glu Gln Ala Leu Thr
        4275                4280                4285            
Lys Gln Arg Leu Glu Glu Glu His Val Thr Cys Leu Leu Gln Val Leu
    4290                4295                4300                
Ala Ser Tyr Ile Asn Pro Val Ser Ser Ala Val Asn Gly Glu Ala Gln
4305                4310                4315                4320
Ser Ser His Glu Thr Arg Gly Gln Asn Ser Asn Ala Leu Pro Ser Val
                4325                4330                4335    
Leu Leu Glu Leu Leu Ser Gln Ser Cys Leu Ile Pro Ala Met Ser Ser
            4340                4345                4350        
Tyr Leu Arg Asn Asp Ser Val Leu Asp Met Ala Arg His Val Pro Leu
        4355                4360                4365            
Tyr Arg Ala Leu Leu Glu Leu Leu Arg Ala Ile Ala Ser Cys Ala Ala
    4370                4375                4380                
Met Val Pro Leu Leu Leu Pro Leu Ser Thr Glu Asn Gly Glu Glu Glu
4385                4390                4395                4400
Glu Glu Gln Ser Glu Cys Gln Thr Ser Val Gly Thr Leu Leu Ala Lys
                4405                4410                4415    
Met Lys Thr Cys Val Asp Thr Tyr Thr Asn Arg Leu Arg Ser Lys Arg
            4420                4425                4430        
Glu Asn Val Lys Thr Gly Val Lys Pro Asp Ala Ser Asp Gln Glu Pro
        4435                4440                4445            
Glu Gly Leu Thr Leu Leu Val Pro Asp Ile Gln Lys Thr Ala Glu Ile
    4450                4455                4460                
Val Tyr Ala Ala Thr Thr Ser Leu Arg Gln Ala Asn Gln Glu Lys Lys
4465                4470                4475                4480
Leu Gly Glu Tyr Ser Lys Lys Ala Ala Met Lys Pro Lys Pro Leu Ser
                4485                4490                4495    
Val Leu Lys Ser Leu Glu Glu Lys Tyr Val Ala Val Met Lys Lys Leu
            4500                4505                4510        
Gln Phe Asp Thr Phe Glu Met Val Ser Glu Asp Glu Asp Gly Lys Leu
        4515                4520                4525            
Gly Phe Lys Val Asn Tyr His Tyr Met Ser Gln Val Lys Asn Ala Asn
    4530                4535                4540                
Asp Ala Asn Ser Ala Ala Arg Ala Arg Arg Leu Ala Gln Glu Ala Val
4545                4550                4555                4560
Thr Leu Ser Thr Ser Leu Pro Leu Ser Ser Ser Ser Ser Val Phe Val
                4565                4570                4575    
Arg Cys Asp Glu Glu Arg Leu Asp Ile Met Lys Val Leu Ile Thr Gly
            4580                4585                4590        
Pro Ala Asp Thr Pro Tyr Ala Asn Gly Cys Phe Glu Phe Asp Val Tyr
        4595                4600                4605            
Phe Pro Gln Asp Tyr Pro Ser Ser Pro Pro Leu Val Asn Leu Glu Thr
    4610                4615                4620                
Thr Gly Gly His Ser Val Arg Phe Asn Pro Asn Leu Tyr Asn Asp Gly
4625                4630                4635                4640
Lys Val Cys Leu Ser Ile Leu Asn Thr Trp His Gly Arg Pro Glu Glu
                4645                4650                4655    
Lys Trp Asn Pro Gln Thr Ser Ser Phe Leu Gln Val Leu Val Ser Val
            4660                4665                4670        
Gln Ser Leu Ile Leu Val Ala Glu Pro Tyr Phe Asn Glu Pro Gly Tyr
        4675                4680                4685            
Glu Arg Ser Arg Gly Thr Pro Ser Gly Thr Gln Ser Ser Arg Glu Tyr
    4690                4695                4700                
Asp Gly Asn Ile Arg Gln Ala Thr Val Lys Trp Ala Met Leu Glu Gln
4705                4710                4715                4720
Ile Arg Asn Pro Ser Pro Cys Phe Lys Glu Val Ile His Lys His Phe
                4725                4730                4735    
Tyr Leu Lys Arg Val Glu Ile Met Ala Gln Cys Glu Glu Trp Ile Ala
            4740                4745                4750        
Asp Ile Gln Gln Tyr Ser Ser Asp Lys Arg Val Gly Arg Thr Met Ser
        4755                4760                4765            
His His Ala Ala Ala Leu Lys Arg His Thr Ala Gln Leu Arg Glu Glu
    4770                4775                4780                
Leu Leu Lys Leu Pro Cys Pro Glu Gly Leu Asp Pro Asp Thr Asp Asp
4785                4790                4795                4800
Ala Pro Glu Val Cys Arg Ala Thr Thr Gly Ala Glu Glu Thr Leu Met
                4805                4810                4815    
His Asp Gln Val Lys Pro Ser Ser Ser Lys Glu Leu Pro Ser Asp Phe
            4820                4825                4830        
Gln Leu
        


<210> 8794
<211> 842
<212> PRT
<213> Homo sapiens

<400> 8794
Ala Val Thr Gln Leu Leu Gly Ser Val Leu Ala Ala Arg Pro Ala Val
 1               5                  10                  15      
Arg Gln Arg Arg Arg Arg Gly Ser Ser Leu Ser Arg Phe Trp Ser Leu
            20                  25                  30          
Gly Pro Thr Val Thr Ala Ala Tyr Leu Arg Leu Leu Glu Pro Pro Glu
        35                  40                  45              
Ser Pro Ser Ala Arg Thr Gly Arg Phe Ala Val Cys Val Ser Pro Thr
    50                  55                  60                  
Pro Pro Arg Leu Pro Pro Arg Ser Ser Leu Arg Ala Asp Met Ser Gly
65                  70                  75                  80  
Asp His Leu His Asn Asp Ser Gln Ile Glu Ala Asp Phe Arg Leu Asn
                85                  90                  95      
Asp Ser His Lys His Lys Asp Lys His Lys Asp Arg Glu His Arg His
            100                 105                 110         
Lys Glu His Lys Lys Glu Lys Asp Arg Glu Lys Ser Lys His Ser Asn
        115                 120                 125             
Ser Glu His Lys Asp Ser Glu Lys Lys His Lys Glu Lys Glu Lys Thr
    130                 135                 140                 
Lys His Lys Asp Gly Ser Ser Glu Lys His Lys Asp Lys His Lys Asp
145                 150                 155                 160 
Arg Asp Lys Glu Lys Arg Lys Glu Glu Lys Val Arg Ala Ser Gly Asp
                165                 170                 175     
Ala Lys Ile Lys Lys Glu Lys Glu Asn Gly Phe Ser Ser Pro Pro Gln
            180                 185                 190         
Ile Lys Asp Glu Pro Glu Asp Asp Gly Tyr Phe Val Pro Pro Lys Glu
        195                 200                 205             
Asp Ile Lys Pro Leu Lys Arg Pro Arg Asp Glu Asp Asp Ala Asp Tyr
    210                 215                 220                 
Lys Pro Lys Lys Ile Lys Thr Glu Asp Thr Lys Lys Glu Lys Lys Arg
225                 230                 235                 240 
Lys Leu Glu Glu Glu Glu Asp Gly Lys Leu Lys Lys Pro Lys Asn Lys
                245                 250                 255     
Asp Lys Asp Lys Lys Val Pro Glu Pro Asp Asn Lys Lys Lys Lys Pro
            260                 265                 270         
Lys Lys Glu Glu Glu Gln Lys Trp Lys Trp Trp Glu Glu Glu Arg Tyr
        275                 280                 285             
Pro Glu Gly Ile Lys Trp Lys Phe Leu Glu His Lys Gly Pro Val Phe
    290                 295                 300                 
Ala Pro Pro Tyr Glu Pro Leu Pro Glu Asn Val Lys Phe Tyr Tyr Asp
305                 310                 315                 320 
Gly Lys Val Met Lys Leu Ser Pro Lys Ala Glu Glu Val Ala Thr Phe
                325                 330                 335     
Phe Ala Lys Met Leu Asp His Glu Tyr Thr Thr Lys Glu Ile Phe Arg
            340                 345                 350         
Lys Asn Phe Phe Lys Asp Trp Arg Lys Glu Met Thr Asn Glu Glu Lys
        355                 360                 365             
Asn Ile Ile Thr Asn Leu Ser Lys Cys Asp Phe Thr Gln Met Ser Gln
    370                 375                 380                 
Tyr Phe Lys Ala Gln Thr Glu Ala Arg Lys Gln Met Ser Lys Glu Glu
385                 390                 395                 400 
Lys Leu Lys Ile Lys Glu Glu Asn Glu Lys Leu Leu Lys Glu Tyr Gly
                405                 410                 415     
Phe Cys Ile Met Asp Asn His Lys Glu Arg Ile Ala Asn Phe Lys Ile
            420                 425                 430         
Glu Pro Pro Gly Leu Phe Arg Gly Arg Gly Asn His Pro Lys Met Gly
        435                 440                 445             
Met Leu Lys Arg Arg Ile Met Pro Glu Asp Ile Ile Ile Asn Cys Ser
    450                 455                 460                 
Lys Asp Ala Lys Val Pro Ser Pro Pro Pro Gly His Lys Trp Lys Glu
465                 470                 475                 480 
Val Arg His Asp Asn Lys Val Thr Trp Leu Val Ser Trp Thr Glu Asn
                485                 490                 495     
Ile Gln Gly Ser Ile Lys Tyr Ile Met Leu Asn Pro Ser Ser Arg Ile
            500                 505                 510         
Lys Gly Glu Lys Asp Trp Gln Lys Tyr Glu Thr Ala Arg Arg Leu Lys
        515                 520                 525             
Lys Cys Val Asp Lys Ile Arg Asn Gln Tyr Arg Glu Asp Trp Lys Ser
    530                 535                 540                 
Lys Glu Met Lys Val Arg Gln Arg Ala Val Ala Leu Tyr Phe Ile Asp
545                 550                 555                 560 
Lys Leu Ala Leu Arg Ala Gly Asn Glu Lys Glu Glu Gly Glu Thr Ala
                565                 570                 575     
Asp Thr Val Gly Cys Cys Ser Leu Arg Val Glu His Ile Asn Leu His
            580                 585                 590         
Pro Glu Leu Asp Gly Gln Glu Tyr Val Val Glu Phe Asp Phe Leu Gly
        595                 600                 605             
Lys Asp Ser Ile Arg Tyr Tyr Asn Lys Val Pro Val Glu Lys Arg Val
    610                 615                 620                 
Phe Lys Asn Leu Gln Leu Phe Met Glu Asn Lys Gln Pro Glu Asp Asp
625                 630                 635                 640 
Leu Phe Asp Arg Leu Asn Thr Gly Ile Leu Asn Lys His Leu Gln Asp
                645                 650                 655     
Leu Met Glu Gly Leu Thr Ala Lys Val Phe Arg Thr Tyr Asn Ala Ser
            660                 665                 670         
Ile Thr Leu Gln Gln Gln Leu Lys Glu Leu Thr Ala Pro Asp Glu Asn
        675                 680                 685             
Ile Pro Ala Lys Ile Leu Ser Tyr Asn Arg Ala Asn Arg Ala Val Ala
    690                 695                 700                 
Ile Leu Cys Asn His Gln Arg Ala Pro Pro Lys Thr Phe Glu Lys Ser
705                 710                 715                 720 
Met Met Asn Leu Gln Thr Lys Ile Asp Ala Lys Lys Glu Gln Leu Ala
                725                 730                 735     
Asp Ala Arg Arg Asp Leu Lys Ser Ala Lys Ala Asp Ala Lys Val Met
            740                 745                 750         
Lys Asp Ala Lys Thr Lys Lys Val Val Glu Ser Lys Lys Lys Ala Val
        755                 760                 765             
Gln Arg Leu Glu Glu Gln Leu Met Lys Leu Glu Val Gln Ala Thr Asp
    770                 775                 780                 
Arg Glu Glu Asn Lys Gln Ile Ala Leu Gly Thr Ser Lys Leu Asn Tyr
785                 790                 795                 800 
Leu Asp Pro Arg Ile Thr Val Ala Trp Cys Lys Lys Trp Gly Val Pro
                805                 810                 815     
Ile Glu Lys Ile Tyr Asn Lys Thr Gln Arg Glu Lys Phe Ala Trp Ala
            820                 825                 830         
Ile Asp Met Ala Asp Glu Asp Tyr Glu Phe
        835                 840         


<210> 8795
<211> 308
<212> PRT
<213> Homo sapiens

<400> 8795
Arg Ser Ser Ala Arg Pro Arg Ala Arg Pro Ala Ala Pro Ala Ala Ala
 1               5                  10                  15      
Pro Gly Pro Leu Ala Ala Ala Thr Met Asp Ala Ile Lys Lys Lys Met
            20                  25                  30          
Gln Met Leu Lys Leu Asp Lys Glu Asn Ala Leu Asp Arg Ala Glu Gln
        35                  40                  45              
Ala Glu Ala Asp Lys Lys Ala Ala Glu Asp Arg Ser Lys Gln Leu Glu
    50                  55                  60                  
Glu Asp Ile Ala Ala Lys Glu Lys Leu Leu Arg Val Ser Glu Asp Glu
65                  70                  75                  80  
Arg Asp Arg Val Leu Glu Glu Leu His Lys Ala Glu Asp Ser Leu Leu
                85                  90                  95      
Ala Ala Glu Glu Ala Ala Ala Lys Ala Glu Ala Asp Val Ala Ser Leu
            100                 105                 110         
Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp Arg Ala Gln Glu
        115                 120                 125             
Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala Glu Lys Ala Ala
    130                 135                 140                 
Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Ser Arg Ala Gln Lys
145                 150                 155                 160 
Asp Glu Glu Lys Met Glu Ile Gln Glu Ile Gln Leu Lys Glu Ala Lys
                165                 170                 175     
His Ile Ala Glu Asp Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys
            180                 185                 190         
Leu Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu Glu Arg Ala Glu
        195                 200                 205             
Leu Ser Glu Gly Lys Cys Ala Glu Leu Glu Glu Glu Leu Lys Thr Val
    210                 215                 220                 
Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu Lys Tyr Ser Gln
225                 230                 235                 240 
Lys Glu Asp Arg Tyr Glu Glu Glu Ile Lys Val Leu Ser Asp Lys Leu
                245                 250                 255     
Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Thr Lys
            260                 265                 270         
Leu Glu Lys Ser Ile Asp Asp Leu Glu Glu Lys Val Ala His Ala Lys
        275                 280                 285             
Glu Glu Asn Leu Ser Met His Gln Met Leu Asp Gln Thr Leu Leu Glu
    290                 295                 300                 
Leu Asn Asn Met
305             


<210> 8796
<211> 227
<212> PRT
<213> Homo sapiens

<400> 8796
Cys Arg Leu Arg Ile Phe Leu Arg Thr Ala Ser Ser Glu His Leu His
 1               5                  10                  15      
Glu Arg Lys Leu Arg Glu Thr Ala Glu Ala Asp Val Ala Ser Leu Asn
            20                  25                  30          
Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg
        35                  40                  45              
Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp
    50                  55                  60                  
Glu Ser Glu Arg Gly Met Lys Val Ile Glu Ser Arg Ala Gln Lys Asp
65                  70                  75                  80  
Glu Glu Lys Met Glu Ile Gln Glu Ile Gln Leu Lys Glu Ala Lys His
                85                  90                  95      
Ile Ala Glu Asp Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu
            100                 105                 110         
Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu Glu Arg Ala Glu Leu
        115                 120                 125             
Ser Glu Gly Gln Val Arg Gln Leu Glu Glu Gln Leu Arg Ile Met Asp
    130                 135                 140                 
Ser Asp Leu Glu Ser Ile Asn Ala Ala Glu Asp Lys Tyr Ser Gln Lys
145                 150                 155                 160 
Glu Asp Arg Tyr Glu Glu Glu Ile Lys Val Leu Ser Asp Lys Leu Lys
                165                 170                 175     
Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Thr Lys Leu
            180                 185                 190         
Glu Lys Ser Ile Asp Asp Leu Glu Glu Lys Val Ala His Ala Lys Glu
        195                 200                 205             
Glu Asn Leu Ser Met His Gln Met Leu Asp Gln Thr Leu Leu Glu Leu
    210                 215                 220                 
Asn Asn Met
225         


<210> 8797
<211> 284
<212> PRT
<213> Homo sapiens

<400> 8797
Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu
 1               5                  10                  15      
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala
            20                  25                  30          
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys
        35                  40                  45              
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu
    50                  55                  60                  
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp
65                  70                  75                  80  
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu
                85                  90                  95      
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys
            100                 105                 110         
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys
        115                 120                 125             
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln
    130                 135                 140                 
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg
145                 150                 155                 160 
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu
                165                 170                 175     
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Gln Val Arg Gln
            180                 185                 190         
Leu Glu Glu Gln Leu Arg Ile Met Asp Gln Thr Leu Lys Ala Leu Met
        195                 200                 205             
Ala Ala Glu Asp Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu
    210                 215                 220                 
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu
225                 230                 235                 240 
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu
                245                 250                 255     
Glu Glu Lys Val Ala His Ala Lys Glu Glu Asn Leu Ser Met His Gln
            260                 265                 270         
Met Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Met
        275                 280                 


<210> 8798
<211> 295
<212> PRT
<213> Homo sapiens

<400> 8798
Leu Met Lys Arg Leu Ala Ala Arg Cys Phe Ala Gly Leu Leu Ile Leu
 1               5                  10                  15      
Ser Pro Leu Thr Val Ile Ser Asp Ser Arg Pro Ala Asp Ser Gly Lys
            20                  25                  30          
Ala Ile Glu Asp Gly Asn Leu Glu Glu Met Glu Glu Glu Val Arg Leu
        35                  40                  45              
Lys Lys Arg Lys Arg Arg Arg Asn Val Asp Lys Asp Pro Ala Lys Glu
    50                  55                  60                  
Asp Val Glu Lys Ala Lys Lys Arg Arg Gly Arg Pro Pro Ala Glu Lys
65                  70                  75                  80  
Leu Ser Pro Asn Pro Pro Lys Leu Thr Lys Gln Met Asn Ala Ile Ile
                85                  90                  95      
Asp Thr Val Ile Asn Tyr Lys Asp Arg Cys Asn Val Glu Lys Val Pro
            100                 105                 110         
Ser Asn Ser Gln Leu Glu Ile Glu Gly Asn Ser Ser Gly Arg Gln Leu
        115                 120                 125             
Ser Glu Val Phe Ile Gln Leu Pro Ser Arg Lys Glu Leu Pro Glu Tyr
    130                 135                 140                 
Tyr Glu Leu Ile Arg Lys Pro Val Asp Phe Lys Lys Ile Lys Glu Arg
145                 150                 155                 160 
Ile Arg Asn His Lys Tyr Arg Ser Leu Gly Asp Leu Glu Lys Asp Val
                165                 170                 175     
Met Leu Leu Cys His Asn Ala Gln Thr Phe Asn Leu Glu Gly Ser Gln
            180                 185                 190         
Ile Tyr Glu Asp Ser Ile Val Leu Gln Ser Val Phe Lys Ser Ala Arg
        195                 200                 205             
Gln Lys Ile Ala Lys Glu Glu Glu Ser Glu Asp Glu Ser Asn Glu Glu
    210                 215                 220                 
Glu Glu Glu Glu Asp Glu Glu Glu Ser Glu Ser Glu Ala Lys Ser Val
225                 230                 235                 240 
Lys Val Lys Ile Lys Leu Asn Lys Lys Asp Asp Lys Gly Arg Asp Lys
                245                 250                 255     
Gly Lys Gly Lys Lys Arg Pro Asn Arg Gly Lys Ala Lys Pro Val Val
            260                 265                 270         
Ser Asp Phe Asp Ser Asp Glu Glu Gln Asp Glu Arg Glu Gln Ser Glu
        275                 280                 285             
Gly Ser Gly Thr Asp Asp Glu
    290                 295 


<210> 8799
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8799
Arg Phe Pro Leu Thr Ile Leu Arg Asp Phe Gly Met Gly Lys Arg Ser
 1               5                  10                  15      
Ile Glu Glu Arg Ile Gln Glu Glu Ala Ser Tyr Leu Leu Glu Glu Phe
            20                  25                  30          
Arg Lys Thr Lys Val Gly Cys Ile Tyr Pro Thr Phe Phe Leu Ser Arg
        35                  40                  45              
Thr Thr Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp
    50                  55                  60                  
Tyr Glu Asp Lys Phe Leu Ser Leu Leu Cys Met Met Leu Glu Ser Phe
65                  70                  75                  80  
Gln Phe Thr Ala Pro Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser Ser
                85                  90                  95      
Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Leu Leu
            100                 105                 110         
Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln Arg
        115                 120                 125             
Thr Leu Asp Pro Asn Ser Pro Gln Asp Phe Ile Asp Ser Phe Leu Ile
    130                 135                 140                 
His Met Gln Glu Val His Pro Ser Ser His Pro Leu Ser Leu Gln Glu
145                 150                 155                 160 
Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu Lys Asn Leu Met Met Ser
                165                 170                 175     
Thr Leu Asn Leu Phe Ile Ala Gly Thr Glu Thr Val Ser Thr Thr Leu
            180                 185                 190         
Arg Tyr Gly Phe Leu Leu Leu Met Lys His Pro Glu Val Glu Ala Lys
        195                 200                 205             
Val His Glu Glu Ile Asp Arg Val Ile Gly Lys Asn Arg Gln Pro Lys
    210                 215                 220                 
Phe Glu Asp Arg Thr Lys Met Pro Tyr Met Glu Ala Val Ile His Glu
225                 230                 235                 240 
Ile Gln Arg Phe Gly Asp Val Ile Pro Met Ser Leu Ala Arg Arg Val
                245                 250                 255     
Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe Leu Pro Lys Gly Thr Glu
            260                 265                 270         
Val Phe Pro Met Leu Gly Ser Val Leu Arg Asp Pro Ser Phe Phe Ser
        275                 280                 285             
Asn Pro Gln Asp Phe Asn Pro Gln His Phe Leu Asp Asp Lys Gly Gln
    290                 295                 300                 
Phe Lys Lys Ser Asp Ala Phe Val Pro Phe Ser Ile Gly Lys Arg Asn
305                 310                 315                 320 
Cys Phe Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe Phe Thr
                325                 330                 335     
Thr Val Met Gln Asn Phe Arg Leu Lys Ser Ser Gln Ser Pro Lys Asp
            340                 345                 350         
Ile Asp Val Ser Pro Lys His Val Gly Phe Ala Thr Ile Pro Arg Asn
        355                 360                 365             
Tyr Thr Met Ser Phe Leu Pro Arg
    370                 375     


<210> 8800
<211> 494
<212> PRT
<213> Homo sapiens

<400> 8800
Met Leu Ala Ser Gly Met Leu Leu Val Ala Leu Leu Val Cys Leu Thr
 1               5                  10                  15      
Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Lys Gly Lys
            20                  25                  30          
Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln
        35                  40                  45              
Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg
    50                  55                  60                  
Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val
65                  70                  75                  80  
Leu Cys Gly His Asp Ala Val Arg Glu Ala Leu Val Asp Gln Ala Glu
                85                  90                  95      
Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Val Phe Lys
            100                 105                 110         
Gly Tyr Gly Val Val Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg
        115                 120                 125             
Arg Phe Ser Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly
    130                 135                 140                 
Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala His
145                 150                 155                 160 
Arg Gly Thr Gly Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg
                165                 170                 175     
Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp
            180                 185                 190         
Tyr Lys Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Ile
        195                 200                 205             
Phe Gln Phe Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser
    210                 215                 220                 
Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Gln Leu
225                 230                 235                 240 
Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln
                245                 250                 255     
Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu
            260                 265                 270         
Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu
        275                 280                 285             
Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Ile Gly Gly Thr Glu
    290                 295                 300                 
Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His
305                 310                 315                 320 
Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly
                325                 330                 335     
Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Met
            340                 345                 350         
Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met
        355                 360                 365             
Ser Leu Ala Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe
    370                 375                 380                 
Leu Pro Lys Gly Thr Glu Val Tyr Pro Met Leu Gly Ser Val Leu Arg
385                 390                 395                 400 
Asp Pro Ser Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe
                405                 410                 415     
Leu Asn Glu Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe
            420                 425                 430         
Ser Ile Gly Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu
        435                 440                 445             
Leu Phe Leu Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser
    450                 455                 460                 
Ser Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe
465                 470                 475                 480 
Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg
                485                 490                 


<210> 8801
<211> 494
<212> PRT
<213> Homo sapiens

<400> 8801
Met Leu Ala Ser Gly Leu Leu Leu Val Thr Leu Leu Ala Cys Leu Thr
 1               5                  10                  15      
Val Met Val Leu Met Ser Val Trp Arg Gln Arg Lys Ser Arg Gly Lys
            20                  25                  30          
Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln
        35                  40                  45              
Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg
    50                  55                  60                  
Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val
65                  70                  75                  80  
Leu Cys Gly His Asp Ala Val Lys Glu Ala Leu Val Asp Gln Ala Glu
                85                  90                  95      
Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Leu Phe Lys
            100                 105                 110         
Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg
        115                 120                 125             
Arg Phe Ser Ile Ala Thr Leu Arg Gly Phe Gly Val Gly Lys Arg Gly
    130                 135                 140                 
Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu
145                 150                 155                 160 
Arg Gly Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg
                165                 170                 175     
Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp
            180                 185                 190         
Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Arg
        195                 200                 205             
Phe Gln Phe Thr Gly Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser
    210                 215                 220                 
Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Glu
225                 230                 235                 240 
Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln
                245                 250                 255     
Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu
            260                 265                 270         
Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu
        275                 280                 285             
Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Phe Ala Gly Thr Glu
    290                 295                 300                 
Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His
305                 310                 315                 320 
Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly
                325                 330                 335     
Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Thr
            340                 345                 350         
Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Met Leu Pro Met
        355                 360                 365             
Gly Leu Ala His Arg Val Asn Lys Asp Thr Lys Phe Arg Asp Phe Phe
    370                 375                 380                 
Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Glu Leu Arg
385                 390                 395                 400 
Asp Pro Arg Phe Phe Ser Asn Pro Gln Asp Cys Ser Pro Gln His Phe
                405                 410                 415     
Leu Asp Glu Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe
            420                 425                 430         
Ser Ile Gly Lys Arg Tyr Cys Phe Gly Glu Gly Leu Ala Arg Met Glu
        435                 440                 445             
Leu Phe Leu Phe Phe Thr Thr Ile Met Gln Asn Phe Arg Phe Lys Ser
    450                 455                 460                 
Pro Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe
465                 470                 475                 480 
Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg
                485                 490                 


<210> 8802
<211> 437
<212> PRT
<213> Homo sapiens

<400> 8802
Met Arg Phe Val Val Ala Leu Val Leu Leu Asn Val Ala Ala Ala Gly
 1               5                  10                  15      
Ala Val Pro Leu Leu Ala Thr Glu Ser Val Lys Gln Glu Glu Ala Gly
            20                  25                  30          
Val Arg Pro Ser Ala Gly Asn Val Ser Thr His Pro Ser Leu Ser Gln
        35                  40                  45              
Arg Pro Gly Gly Ser Thr Lys Ser His Pro Glu Pro Gln Thr Pro Lys
    50                  55                  60                  
Asp Ser Pro Ser Lys Ser Ser Ala Glu Ala Gln Thr Pro Glu Asp Thr
65                  70                  75                  80  
Pro Asn Lys Ser Gly Gly Glu Ala Lys Thr Leu Lys Asp Ser Ser Asn
                85                  90                  95      
Lys Ser Gly Ala Glu Ala Gln Thr Pro Lys Gly Ser Thr Ser Lys Ser
            100                 105                 110         
Gly Ser Glu Ala Gln Thr Thr Lys Asp Ser Thr Ser Lys Ser His Pro
        115                 120                 125             
Glu Leu Gln Thr Pro Lys Asp Ser Thr Gly Lys Ser Gly Ala Glu Ala
    130                 135                 140                 
Gln Thr Pro Glu Asp Ser Pro Asn Arg Ser Gly Ala Glu Pro Lys Thr
145                 150                 155                 160 
Gln Lys Asp Ser Pro Ser Lys Ser Gly Ser Glu Ala Gln Thr Thr Lys
                165                 170                 175     
Asp Val Pro Asn Lys Ser Gly Ala Asp Gly Gln Thr Pro Lys Asp Gly
            180                 185                 190         
Ser Ser Lys Ser Gly Ala Glu Asp Gln Thr Pro Lys Asp Val Pro Asn
        195                 200                 205             
Lys Ser Gly Ala Glu Lys Gln Thr Pro Lys Asp Gly Ser Asn Lys Ser
    210                 215                 220                 
Gly Ala Glu Glu Gln Gly Pro Ile Asp Gly Pro Ser Lys Ser Gly Ala
225                 230                 235                 240 
Glu Glu Gln Thr Ser Lys Asp Ser Pro Asn Lys Val Val Pro Glu Gln
                245                 250                 255     
Pro Ser Arg Lys Asp His Ser Lys Pro Ile Ser Asn Pro Ser Asp Asn
            260                 265                 270         
Lys Glu Leu Pro Lys Ala Asp Thr Asn Gln Leu Ala Asp Lys Gly Lys
        275                 280                 285             
Leu Ser Pro His Ala Phe Lys Thr Glu Ser Gly Glu Glu Thr Asp Leu
    290                 295                 300                 
Ile Ser Pro Pro Gln Glu Glu Val Lys Ser Ser Glu Pro Thr Glu Asp
305                 310                 315                 320 
Val Gly Pro Lys Glu Ala Glu Asp Asp Asp Thr Gly Pro Glu Glu Gly
                325                 330                 335     
Ser Pro Pro Lys Glu Glu Lys Glu Lys Met Ser Gly Ser Ala Ser Ser
            340                 345                 350         
Glu Asn Arg Glu Gly Thr Leu Ser Asp Ser Thr Gly Ser Glu Lys Asp
        355                 360                 365             
Asp Leu Tyr Pro Asn Gly Ser Gly Asn Gly Ser Ala Glu Ser Ser His
    370                 375                 380                 
Phe Phe Ala Tyr Leu Val Thr Ala Ala Ile Leu Val Ala Val Leu Tyr
385                 390                 395                 400 
Ile Ala His His Asn Lys Arg Lys Ile Ile Ala Phe Val Leu Glu Gly
                405                 410                 415     
Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg
            420                 425                 430         
Leu Asp Gln Lys Ser
        435         


<210> 8803
<211> 453
<212> PRT
<213> Homo sapiens

<400> 8803
Met Arg Phe Val Val Ala Leu Val Leu Leu Asn Val Ala Ala Ala Gly
 1               5                  10                  15      
Ala Val Pro Leu Leu Ala Thr Glu Ser Val Lys Gln Glu Glu Ala Gly
            20                  25                  30          
Val Arg Pro Ser Ala Gly Asn Val Ser Thr His Pro Ser Leu Ser Gln
        35                  40                  45              
Arg Pro Gly Gly Ser Thr Lys Ser His Pro Glu Pro Gln Thr Pro Lys
    50                  55                  60                  
Asp Ser Pro Ser Lys Ser Ser Ala Glu Ala Gln Thr Pro Glu Asp Thr
65                  70                  75                  80  
Pro Asn Lys Ser Gly Gly Glu Ala Lys Thr Leu Lys Asp Ser Ser Asn
                85                  90                  95      
Lys Ser Gly Ala Glu Ala Gln Thr Pro Lys Gly Ser Thr Ser Lys Ser
            100                 105                 110         
Gly Ser Glu Ala Gln Thr Thr Lys Asp Ser Thr Ser Lys Ser His Pro
        115                 120                 125             
Glu Leu Gln Thr Pro Lys Asp Ser Thr Gly Lys Ser Gly Ala Glu Ala
    130                 135                 140                 
Gln Thr Pro Glu Asp Ser Pro Asn Arg Ser Gly Ala Glu Pro Lys Thr
145                 150                 155                 160 
Gln Lys Asp Ser Pro Ser Lys Ser Gly Ser Glu Ala Gln Thr Thr Lys
                165                 170                 175     
Asp Val Pro Asn Lys Ser Gly Ala Asp Gly Gln Thr Pro Lys Asp Gly
            180                 185                 190         
Ser Ser Lys Ser Gly Ala Glu Asp Gln Thr Pro Lys Asp Val Pro Asn
        195                 200                 205             
Lys Ser Gly Ala Glu Lys Gln Thr Pro Lys Asp Gly Ser Asn Lys Ser
    210                 215                 220                 
Gly Ala Glu Glu Gln Gly Pro Ile Asp Gly Pro Ser Lys Ser Gly Ala
225                 230                 235                 240 
Glu Glu Gln Thr Ser Lys Asp Ser Pro Asn Lys Val Val Pro Glu Gln
                245                 250                 255     
Pro Ser Arg Lys Asp His Ser Lys Pro Ile Ser Asn Pro Ser Asp Asn
            260                 265                 270         
Lys Glu Leu Pro Lys Ala Asp Thr Asn Gln Leu Ala Asp Lys Gly Lys
        275                 280                 285             
Leu Ser Pro His Ala Phe Lys Thr Glu Ser Gly Glu Glu Thr Asp Leu
    290                 295                 300                 
Ile Ser Pro Pro Gln Glu Glu Val Lys Ser Ser Glu Pro Thr Glu Asp
305                 310                 315                 320 
Val Gly Pro Lys Glu Ala Glu Asp Asp Asp Thr Gly Pro Glu Glu Gly
                325                 330                 335     
Ser Pro Pro Lys Glu Glu Lys Glu Lys Met Ser Gly Ser Ala Ser Ser
            340                 345                 350         
Glu Asn Arg Glu Gly Thr Leu Ser Asp Ser Thr Gly Ser Glu Lys Asp
        355                 360                 365             
Asp Leu Tyr Pro Asn Gly Ser Gly Asn Gly Ser Ala Glu Ser Ser His
    370                 375                 380                 
Phe Phe Ala Tyr Leu Val Thr Ala Ala Ile Leu Val Ala Val Leu Tyr
385                 390                 395                 400 
Ile Ala His His Asn Lys Arg Lys Ile Ile Ala Phe Val Leu Glu Gly
                405                 410                 415     
Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg
            420                 425                 430         
Leu Asp Gln Lys Ile Phe Ser Pro Pro Ser Pro Asn Arg Met Val Tyr
        435                 440                 445             
Ser Ser Gly Lys Arg
    450             


<210> 8804
<211> 480
<212> PRT
<213> Homo sapiens

<400> 8804
Met Arg Phe Val Val Ala Leu Val Leu Leu Asn Val Ala Ala Ala Gly
 1               5                  10                  15      
Ala Val Pro Leu Leu Ala Thr Glu Ser Val Lys Gln Glu Glu Ala Gly
            20                  25                  30          
Val Arg Pro Ser Ala Gly Asn Val Ser Thr His Pro Ser Leu Ser Gln
        35                  40                  45              
Arg Pro Gly Gly Ser Thr Lys Ser His Pro Glu Pro Gln Thr Pro Lys
    50                  55                  60                  
Asp Ser Pro Ser Lys Ser Ser Ala Glu Ala Gln Thr Pro Glu Asp Thr
65                  70                  75                  80  
Pro Asn Lys Ser Gly Gly Glu Ala Lys Thr Leu Lys Asp Ser Ser Asn
                85                  90                  95      
Lys Ser Gly Ala Glu Ala Gln Thr Pro Lys Gly Ser Thr Ser Lys Ser
            100                 105                 110         
Gly Ser Glu Ala Gln Thr Thr Lys Asp Ser Thr Ser Lys Ser His Pro
        115                 120                 125             
Glu Leu Gln Thr Pro Lys Asp Ser Thr Gly Lys Ser Gly Ala Glu Ala
    130                 135                 140                 
Gln Thr Pro Glu Asp Ser Pro Asn Arg Ser Gly Ala Glu Pro Lys Thr
145                 150                 155                 160 
Gln Lys Asp Ser Pro Ser Lys Ser Gly Ser Glu Ala Gln Thr Thr Lys
                165                 170                 175     
Asp Val Pro Asn Lys Ser Gly Ala Asp Gly Gln Thr Pro Lys Asp Gly
            180                 185                 190         
Ser Ser Lys Ser Gly Ala Glu Asp Gln Thr Pro Lys Asp Val Pro Asn
        195                 200                 205             
Lys Ser Gly Ala Glu Lys Gln Thr Pro Lys Asp Gly Ser Asn Lys Ser
    210                 215                 220                 
Gly Ala Glu Glu Gln Gly Pro Ile Asp Gly Pro Ser Lys Ser Gly Ala
225                 230                 235                 240 
Glu Glu Gln Thr Ser Lys Asp Ser Pro Asn Lys Val Val Pro Glu Gln
                245                 250                 255     
Pro Ser Arg Lys Asp His Ser Lys Pro Ile Ser Asn Pro Ser Asp Asn
            260                 265                 270         
Lys Glu Leu Pro Lys Ala Asp Thr Asn Gln Leu Ala Asp Lys Gly Lys
        275                 280                 285             
Leu Ser Pro His Ala Phe Lys Thr Glu Ser Gly Glu Glu Thr Asp Leu
    290                 295                 300                 
Ile Ser Pro Pro Gln Glu Glu Val Lys Ser Ser Glu Pro Thr Glu Asp
305                 310                 315                 320 
Val Gly Pro Lys Glu Ala Glu Asp Asp Asp Thr Gly Pro Glu Glu Gly
                325                 330                 335     
Ser Pro Pro Lys Glu Glu Lys Glu Lys Met Ser Gly Ser Ala Ser Ser
            340                 345                 350         
Glu Asn Arg Glu Gly Thr Leu Ser Asp Ser Thr Gly Ser Glu Lys Asp
        355                 360                 365             
Asp Leu Tyr Pro Asn Gly Ser Gly Asn Gly Ser Ala Glu Ser Ser His
    370                 375                 380                 
Phe Phe Ala Tyr Leu Val Thr Ala Ala Ile Leu Val Ala Val Leu Tyr
385                 390                 395                 400 
Ile Ala His His Asn Lys Arg Lys Ile Ile Ala Phe Val Leu Glu Gly
                405                 410                 415     
Lys Arg Ser Lys Val Thr Arg Arg Pro Lys Ala Ser Asp Tyr Gln Arg
            420                 425                 430         
Leu Asp Gln Lys Tyr Val Leu Ile Leu Asn Val Phe Pro Ala Pro Pro
        435                 440                 445             
Lys Arg Ser Phe Leu Pro Gln Val Leu Thr Glu Trp Tyr Ile Pro Leu
    450                 455                 460                 
Glu Lys Asp Glu Arg His Gln Trp Ile Val Leu Leu Ser Phe Gln Leu
465                 470                 475                 480 


<210> 8805
<211> 633
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 187
<223> Xaa = Any Amino Acid

<400> 8805
Met Ala Leu Ala Val Ala Ala Ala Ala Glu Ala Gln Ala Ala Ala Ala
 1               5                  10                  15      
Ala Asp Asn Ile Thr Val Leu His Val Lys Leu Thr Glu Ser Ala Ile
            20                  25                  30          
Gln Ala Leu Gln Thr Tyr Gln Ser His Lys Asn Leu Ile Ser Phe Arg
        35                  40                  45              
Pro Ser Ile Gln Phe Gln Arg Leu Gln Glu Leu Val Lys Ile Pro Lys
    50                  55                  60                  
Asn Asp Pro Leu Asn Glu Val His Asn Phe Asn Phe Tyr Leu Ser Asn
65                  70                  75                  80  
Val Gly Lys Asp Asn Pro Gln Gly Ser Phe Asp Cys Val Gln Gln Thr
                85                  90                  95      
Phe Ser Ser Ser Gly Ala Ser Gln Leu Asn Cys Leu Gly Phe Ile Gln
            100                 105                 110         
Asp Lys Ile Thr Val Cys Ala Thr Asn Asp Ser Asp Gln Met Thr Arg
        115                 120                 125             
Glu Arg Thr Thr Gln Ala Glu Glu Glu Ser Arg Asn Arg Ser Thr Glu
    130                 135                 140                 
Val Ile Lys Pro Gly Gly Pro Tyr Val Gly Lys Arg Val Gln Ile Arg
145                 150                 155                 160 
Lys Ala Pro Gln Ala Val Ser Asp Thr Val Pro Glu Arg Lys Arg Ser
                165                 170                 175     
Thr Pro Met Asn Pro Ala Asn Pro Ile Arg Xaa Thr His Ser Ser Ser
            180                 185                 190         
Ser Val Ser Gln Lys Pro Tyr Arg Asp Arg Val Val His Leu Leu Ala
        195                 200                 205             
Leu Lys Ala Tyr Lys Lys Pro Glu Leu Leu Ala Arg Leu Gln Lys Asp
    210                 215                 220                 
Gly Val Asn Gln Lys Asp Arg Asn Ser Leu Gly Ala Ile Leu Gln Gln
225                 230                 235                 240 
Val Ala Asn Leu Asn Pro Lys Asp Leu Ser Tyr Thr Ser Lys Asp Tyr
                245                 250                 255     
Val Phe Lys Glu Leu Gln Arg Asp Trp Pro Gly Tyr Ser Glu Ile Asp
            260                 265                 270         
Thr Trp Ser Leu Glu Ser Met Leu Ser Arg Lys Leu Asn Pro Ser Gln
        275                 280                 285             
Asn Ala Ala Gly Thr Ser Arg Ser Glu Ser Pro Val Cys Ser Ser Arg
    290                 295                 300                 
Asn Ala Val Ser Ser Pro Gln Thr Arg Leu Leu Asp Ser Glu Phe Ile
305                 310                 315                 320 
Asp His Leu Met Asp Lys Lys Ala Arg Ile Ser His Leu Thr Ser Arg
                325                 330                 335     
Val Pro Pro Thr Leu Asn Gly His Leu Asn Pro Thr Ser Glu Lys Ser
            340                 345                 350         
Ala Ala Gly Leu Pro Leu Pro Pro Ala Ala Ala Ala Ile Pro Thr Pro
        355                 360                 365             
Pro Pro Leu Pro Ser Thr His Leu Pro Val Ser His Pro Pro Gln Ile
    370                 375                 380                 
Val Asn Ser Asn Ser Asn Ser Pro Ser Thr Pro Glu Gly Arg Gly Ala
385                 390                 395                 400 
Gln Asp Leu Pro Val Asp Ser Phe Ser Gln Asn Asn Ser Ile Tyr Glu
                405                 410                 415     
Asn Gln Gln Asp Lys Tyr Thr Ser Arg Thr Ser Leu Glu Thr Leu Pro
            420                 425                 430         
Pro Gly Ser Val Leu Leu Lys Cys Pro Lys Pro Met Glu Glu Asn His
        435                 440                 445             
Ser Val Ser His Lys Lys Ser Lys Lys Lys Ser Lys Lys His Lys Glu
    450                 455                 460                 
Lys Asp Gln Ile Lys Lys His Asp Ile Glu Thr Ile Glu Glu Lys Glu
465                 470                 475                 480 
Lys Asp Leu Lys Arg Glu Glu Glu Ile Ala Lys Leu Asn Asn Ser Ser
                485                 490                 495     
Pro Asn Ser Ser Gly Gly Ala Lys Glu Asp Cys Thr Ala Ser Met Glu
            500                 505                 510         
Pro Ser Ala Ile Glu Leu Pro Asp Tyr Leu Ile Lys Tyr Ile Ala Ile
        515                 520                 525             
Ile Ser Tyr Glu Gln Arg Arg Asn Tyr Lys Asp Asp Val Ser Ala Glu
    530                 535                 540                 
Tyr Asp Glu Tyr Arg Ala Leu His Ala Arg Met Glu Thr Val Ala Arg
545                 550                 555                 560 
Arg Phe Ile Lys Leu Asp Ala Gln Arg Lys Arg Leu Ser Pro Gly Ser
                565                 570                 575     
Lys Glu Tyr Gln Asn Val His Glu Glu Val Leu Gln Glu Tyr Arg Lys
            580                 585                 590         
Ile Lys Gln Ser Ser Pro Asn Tyr His Glu Glu Lys Tyr Arg Cys Glu
        595                 600                 605             
Tyr Leu His Asn Lys Leu Ala His Ile Lys Arg Leu Leu Gly Glu Phe
    610                 615                 620                 
Asp Gln Gln Gln Ala Glu Ser Trp Pro
625                 630             


<210> 8806
<211> 368
<212> PRT
<213> Homo sapiens

<400> 8806
Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe
 1               5                  10                  15      
Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly
            20                  25                  30          
Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu
        35                  40                  45              
Thr Gly Lys Gln Pro Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln
    50                  55                  60                  
Phe Gly Phe Pro Leu Thr Gly Thr Glu Ala Arg Cys Tyr Thr Asn His
65                  70                  75                  80  
Ala Leu Ser Tyr Asp Gln Ala Lys Arg Val Pro Arg Trp Val Leu Glu
                85                  90                  95      
His Ile Ser Lys Ser Lys Ile Met Gly Asp Ala Asp Arg Lys His Cys
            100                 105                 110         
Lys Phe Lys Pro Asp Pro Asn Ile Pro Pro Thr Phe Ser Ala Phe Asn
        115                 120                 125             
Glu Asp Tyr Val Gly Ser Gly Trp Ser Arg Gly His Met Ala Pro Ala
    130                 135                 140                 
Gly Asn Asn Lys Phe Ser Ser Lys Ala Met Ala Glu Thr Phe Tyr Leu
145                 150                 155                 160 
Ser Asn Ile Val Pro Gln Asp Phe Asp Asn Asn Ser Gly Tyr Trp Asn
                165                 170                 175     
Arg Ile Glu Met Tyr Cys Arg Glu Leu Thr Glu Arg Phe Glu Asp Val
            180                 185                 190         
Trp Val Val Ser Gly Pro Leu Thr Leu Pro Gln Thr Arg Gly Asp Gly
        195                 200                 205             
Lys Lys Ile Val Ser Tyr Gln Val Ile Gly Glu Asp Asn Val Ala Val
    210                 215                 220                 
Pro Ser His Leu Tyr Lys Val Ile Leu Ala Arg Arg Ser Ser Val Ser
225                 230                 235                 240 
Thr Glu Pro Leu Ala Leu Gly Ala Phe Val Val Pro Asn Glu Ala Ile
                245                 250                 255     
Gly Phe Gln Pro Gln Leu Thr Glu Phe Gln Val Ser Leu Gln Asp Leu
            260                 265                 270         
Glu Lys Leu Ser Val Leu Val Phe Phe Pro His Leu Asp Arg Thr Ser
        275                 280                 285             
Asp Ile Arg Asn Ile Cys Ser Val Asp Thr Cys Lys Leu Leu Asp Phe
    290                 295                 300                 
Gln Glu Phe Thr Leu Tyr Leu Ser Thr Arg Lys Ile Glu Gly Ala Arg
305                 310                 315                 320 
Ser Val Leu Arg Leu Glu Lys Ile Met Glu Asn Leu Lys Asn Ala Glu
                325                 330                 335     
Ile Glu Pro Asp Asp Tyr Phe Met Ser Arg Tyr Glu Lys Lys Leu Glu
            340                 345                 350         
Glu Leu Lys Ala Lys Glu Gln Ser Gly Thr Gln Ile Arg Lys Pro Ser
        355                 360                 365             


<210> 8807
<211> 149
<212> PRT
<213> Homo sapiens

<400> 8807
Met Ala Pro Ala Gly Asn Asn Lys Phe Ser Ser Lys Ala Met Ala Glu
 1               5                  10                  15      
Thr Phe Tyr Leu Ser Asn Ile Val Pro Gln Asp Phe Asp Asn Asn Ser
            20                  25                  30          
Gly Tyr Trp Asn Arg Ile Glu Met Tyr Cys Arg Glu Leu Thr Glu Arg
        35                  40                  45              
Phe Glu Asp Val Trp Val Val Ser Gly Pro Leu Thr Leu Pro Gln Thr
    50                  55                  60                  
Arg Gly Asp Gly Lys Lys Ile Val Ser Tyr Gln Val Ile Gly Glu Asp
65                  70                  75                  80  
Asn Val Ala Val Pro Ser His Leu Tyr Lys Asp His Ala Gly Cys Cys
                85                  90                  95      
Val Glu Ser Pro Leu Gly Thr Arg Thr Ser Glu Glu Ala Thr Ala Arg
            100                 105                 110         
Ile Gln Glu Arg Asp Asp Gly Gly Ser Asp Gln Arg Ser Gly Leu Val
        115                 120                 125             
Glu Leu Gly Ile Tyr Phe Glu Gly Arg Ala Asn Arg Ile Ser Gly Arg
    130                 135                 140                 
Ile Gly Cys Arg Val
145                 


<210> 8808
<211> 565
<212> PRT
<213> Homo sapiens

<400> 8808
Thr Ser Ser Arg Ala Val Cys Ser Ala Ala Ala Ala Ala Ala Ala Ala
 1               5                  10                  15      
Ala Leu Ser Val Trp Pro Ala Gly Pro Val Gly Val Cys Ser Arg Thr
            20                  25                  30          
Asp Glu Gln Arg Val Ala Val Leu Arg Gln Leu Glu Met Ser Glu Pro
        35                  40                  45              
Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg Val Val Lys Ala
    50                  55                  60                  
Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys Glu Val Phe Asp
65                  70                  75                  80  
Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala His Leu Met Lys
                85                  90                  95      
Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile Ile Thr Glu Gly
            100                 105                 110         
Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp Ile Asp Ala Pro
        115                 120                 125             
Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys
    130                 135                 140                 
Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu
145                 150                 155                 160 
Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr
                165                 170                 175     
Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu Phe Leu Leu Arg
            180                 185                 190         
Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln
        195                 200                 205             
Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp Ala Cys Met Asp
    210                 215                 220                 
Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn Gln Gln Phe Leu
225                 230                 235                 240 
Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr Leu Asp Asp Ile
                245                 250                 255     
Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr Gly Pro Met Cys
            260                 265                 270         
Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly Asn Glu Lys Thr
        275                 280                 285             
Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr
    290                 295                 300                 
Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn Asn Leu Leu Ser
305                 310                 315                 320 
Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg
                325                 330                 335     
Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala
            340                 345                 350         
Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr
        355                 360                 365             
Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro
    370                 375                 380                 
Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe
385                 390                 395                 400 
Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val Leu Asn Ile Cys
                405                 410                 415     
Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe Asp Gly Ala Thr
            420                 425                 430         
Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile Arg Ala Ile Gly
        435                 440                 445             
Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val
    450                 455                 460                 
Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val
465                 470                 475                 480 
Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile
                485                 490                 495     
Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln His Lys Ile Thr
            500                 505                 510         
Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro
        515                 520                 525             
Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu Asn Ser Ile Asn
    530                 535                 540                 
Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser Asn Gly Ser Asn
545                 550                 555                 560 
Ser Ser Asn Ile Gln
                565 


<210> 8809
<211> 406
<212> PRT
<213> Homo sapiens

<400> 8809
Met Ser Leu Val Glu Leu Leu Leu Trp Trp Asn Cys Phe Ser Arg Thr
 1               5                  10                  15      
Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile Gln
            20                  25                  30          
Val Ala Arg Gly Gln Thr Ala Val Leu Pro Cys Thr Phe Thr Thr Ser
        35                  40                  45              
Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu Ser
    50                  55                  60                  
Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met
65                  70                  75                  80  
Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr
                85                  90                  95      
Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser
            100                 105                 110         
Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile Gly
        115                 120                 125             
Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser
    130                 135                 140                 
Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp Val
145                 150                 155                 160 
Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu
                165                 170                 175     
Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln
            180                 185                 190         
Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser
        195                 200                 205             
Ser Ala Gln Pro Arg Asn Ile Gly Leu Ile Ala Gly Ala Ile Gly Thr
    210                 215                 220                 
Gly Ala Val Ile Ile Ile Phe Cys Ile Ala Leu Ile Leu Gly Ala Phe
225                 230                 235                 240 
Phe His Trp Arg Ser Lys Asn Lys Glu Glu Glu Glu Glu Glu Ile Pro
                245                 250                 255     
Asn Glu Ile Arg Glu Asp Asp Leu Pro Pro Lys Cys Ser Ser Ala Lys
            260                 265                 270         
Ala Phe His Thr Glu Ile Ser Ser Ser Asp Asn Asn Thr Leu Thr Ser
        275                 280                 285             
Ser Asn Ala Tyr Asn Ser Arg Tyr Trp Ser Asn Asn Pro Lys Val His
    290                 295                 300                 
Arg Asn Thr Asp Ser Val Ser His Phe Ser Asp Leu Gly Gln Ser Phe
305                 310                 315                 320 
Ser Phe His Ser Gly Asn Ala Asn Ile Pro Ser Ile Tyr Ala Asn Gly
                325                 330                 335     
Thr His Leu Val Pro Gly Gln His Lys Thr Leu Val Ala Thr Ala Asn
            340                 345                 350         
Arg Gly Ser Ser Pro Gln Val Met Ser Arg Ser Asn Gly Ser Val Ser
        355                 360                 365             
Arg Lys Pro Arg Pro Pro His Thr His Ser Tyr Thr Ile Ser His Ala
    370                 375                 380                 
Thr Leu Glu Arg Ile Gly Ala Val Pro Val Met Val Pro Ala Gln Ser
385                 390                 395                 400 
Arg Ala Gly Ser Leu Val
                405     


<210> 8810
<211> 430
<212> PRT
<213> Homo sapiens

<400> 8810
Met Ser Leu Val Glu Leu Leu Leu Trp Trp Asn Cys Phe Ser Arg Thr
 1               5                  10                  15      
Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile Gln
            20                  25                  30          
Val Ala Arg Gly Gln Thr Ala Val Leu Pro Cys Thr Phe Thr Thr Ser
        35                  40                  45              
Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu Ser
    50                  55                  60                  
Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met
65                  70                  75                  80  
Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr
                85                  90                  95      
Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser
            100                 105                 110         
Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile Gly
        115                 120                 125             
Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser
    130                 135                 140                 
Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp Val
145                 150                 155                 160 
Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu
                165                 170                 175     
Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln
            180                 185                 190         
Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser
        195                 200                 205             
Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser Thr
    210                 215                 220                 
Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile Gly
225                 230                 235                 240 
Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe Cys
                245                 250                 255     
Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn Lys
            260                 265                 270         
Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp Leu
        275                 280                 285             
Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser Ser
    290                 295                 300                 
Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg Tyr
305                 310                 315                 320 
Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser His
                325                 330                 335     
Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala Asn
            340                 345                 350         
Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln His
        355                 360                 365             
Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val Met
    370                 375                 380                 
Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His Thr
385                 390                 395                 400 
His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala Val
                405                 410                 415     
Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val
            420                 425                 430 


<210> 8811
<211> 379
<212> PRT
<213> Homo sapiens

<400> 8811
Met Gly Tyr Ala Arg Lys Val Gly Trp Val Thr Ala Gly Leu Val Ile
 1               5                  10                  15      
Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Lys
            20                  25                  30          
Gln Asn Lys Glu Lys Met Ala Glu Gly Gly Ser Gly Asp Val Asp Asp
        35                  40                  45              
Ala Gly Asp Cys Ser Gly Ala Arg Tyr Asn Asp Trp Ser Asp Asp Asp
    50                  55                  60                  
Asp Asp Ser Asn Glu Ser Lys Ser Ile Val Trp Tyr Pro Pro Trp Ala
65                  70                  75                  80  
Arg Ile Gly Thr Glu Ala Gly Thr Arg Ala Arg Ala Arg Ala Arg Ala
                85                  90                  95      
Arg Ala Thr Arg Ala Arg Arg Ala Val Gln Lys Arg Ala Ser Pro Asn
            100                 105                 110         
Ser Asp Asp Thr Val Leu Ser Pro Gln Glu Leu Gln Lys Val Leu Cys
        115                 120                 125             
Leu Val Glu Met Ser Glu Lys Pro Tyr Ile Leu Glu Ala Ala Leu Ile
    130                 135                 140                 
Ala Leu Gly Asn Asn Ala Ala Tyr Ala Phe Asn Arg Asp Ile Ile Arg
145                 150                 155                 160 
Asp Leu Gly Gly Leu Pro Ile Val Ala Lys Ile Leu Asn Thr Arg Asp
                165                 170                 175     
Pro Ile Val Lys Glu Lys Ala Leu Ile Val Leu Asn Asn Leu Ser Val
            180                 185                 190         
Asn Ala Glu Asn Gln Arg Arg Leu Lys Val Tyr Met Asn Gln Val Cys
        195                 200                 205             
Asp Asp Thr Ile Thr Ser Arg Leu Asn Ser Ser Val Gln Leu Ala Gly
    210                 215                 220                 
Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn Glu Tyr Gln His Met
225                 230                 235                 240 
Leu Ala Asn Ser Ile Ser Asp Phe Phe Arg Leu Phe Ser Ala Gly Asn
                245                 250                 255     
Glu Glu Thr Lys Leu Gln Val Leu Lys Leu Leu Leu Asn Leu Ala Glu
            260                 265                 270         
Asn Pro Ala Met Thr Arg Glu Leu Leu Arg Ala Gln Val Pro Ser Ser
        275                 280                 285             
Leu Gly Ser Leu Phe Asn Lys Lys Glu Asn Lys Glu Val Ile Leu Lys
    290                 295                 300                 
Leu Leu Val Ile Phe Glu Asn Ile Asn Asp Asn Phe Lys Trp Glu Glu
305                 310                 315                 320 
Asn Glu Pro Thr Gln Asn Gln Phe Gly Glu Gly Ser Leu Phe Phe Phe
                325                 330                 335     
Leu Lys Glu Phe Gln Val Cys Ala Asp Lys Val Leu Gly Ile Glu Ser
            340                 345                 350         
His His Asp Phe Leu Val Lys Val Lys Val Gly Lys Phe Met Ala Lys
        355                 360                 365             
Leu Ala Glu His Met Phe Pro Lys Ser Gln Glu
    370                 375                 


<210> 8812
<211> 1452
<212> PRT
<213> Homo sapiens

<400> 8812
Met Arg Thr Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu
 1               5                  10                  15      
Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro
            20                  25                  30          
Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp
        35                  40                  45              
Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro
    50                  55                  60                  
Ser Gly Ser Leu Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln
65                  70                  75                  80  
Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys
                85                  90                  95      
Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly
            100                 105                 110         
Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro
        115                 120                 125             
Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu
    130                 135                 140                 
Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu
145                 150                 155                 160 
Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys
                165                 170                 175     
Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln
            180                 185                 190         
Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala
        195                 200                 205             
Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp
    210                 215                 220                 
Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg
225                 230                 235                 240 
Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly
                245                 250                 255     
Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn
            260                 265                 270         
Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro
        275                 280                 285             
Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala
    290                 295                 300                 
Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr
305                 310                 315                 320 
Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr
                325                 330                 335     
Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser
            340                 345                 350         
Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro
        355                 360                 365             
Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg
    370                 375                 380                 
Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp
385                 390                 395                 400 
Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr
                405                 410                 415     
Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu
            420                 425                 430         
Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn
        435                 440                 445             
Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro
    450                 455                 460                 
Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp Glu Asp
465                 470                 475                 480 
Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr Phe Glu
                485                 490                 495     
Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr Gly Val
            500                 505                 510         
Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe Asp Pro
        515                 520                 525             
Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu Gly Asn
    530                 535                 540                 
Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr Tyr Ser
545                 550                 555                 560 
Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro Ala Thr
                565                 570                 575     
Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala Tyr Glu
            580                 585                 590         
Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val Met Leu
        595                 600                 605             
Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln Ile Val
    610                 615                 620                 
Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu Ile Leu
625                 630                 635                 640 
Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu Leu Asn
                645                 650                 655     
Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu Gln Ala
            660                 665                 670         
Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly Tyr Trp
        675                 680                 685             
Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Phe Gln Ala
    690                 695                 700                 
Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln Val Ala
705                 710                 715                 720 
Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu Lys Gln
                725                 730                 735     
Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile Leu Leu
            740                 745                 750         
Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys Arg Lys
        755                 760                 765             
Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln Glu Met
    770                 775                 780                 
Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln Gly Thr
785                 790                 795                 800 
Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu Asn Gly
                805                 810                 815     
Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn Thr Leu
            820                 825                 830         
Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Glu Thr His Thr Met
        835                 840                 845             
Ala Ser Asp Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys Lys Arg
    850                 855                 860                 
Glu Pro Ala Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile
865                 870                 875                 880 
Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys Ala Glu
                885                 890                 895     
Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly Gln Ser
            900                 905                 910         
Ala Pro Trp Asp Ser Ala Lys Lys Asp Glu Asn Arg Met Lys Asn Arg
        915                 920                 925             
Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu Gln Thr
    930                 935                 940                 
Ile Glu Gly Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr Ile Asp
945                 950                 955                 960 
Gly Tyr His Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro Met Gln
                965                 970                 975     
Glu Thr Ile Tyr Asp Phe Trp Arg Met Val Trp His Glu Asn Thr Ala
            980                 985                 990         
Ser Ile Ile Met Val Thr Asn Leu Val Glu Val Gly Arg Val Lys Cys
        995                 1000                1005            
Cys Lys Tyr Trp Pro Asp Asp Thr Glu Ile Tyr Lys Asp Ile Lys Val
    1010                1015                1020                
Thr Leu Ile Glu Thr Glu Leu Leu Ala Glu Tyr Val Ile Arg Thr Phe
1025                1030                1035                1040
Ala Val Glu Lys Arg Gly Val His Glu Ile Arg Glu Ile Arg Gln Phe
                1045                1050                1055    
His Phe Thr Gly Trp Pro Asp His Gly Val Pro Tyr His Ala Thr Gly
            1060                1065                1070        
Leu Leu Gly Phe Val Arg Gln Val Lys Ser Lys Ser Pro Pro Ser Ala
        1075                1080                1085            
Gly Pro Leu Val Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Cys
    1090                1095                1100                
Phe Ile Val Ile Asp Ile Met Leu Asp Met Ala Glu Arg Glu Gly Val
1105                1110                1115                1120
Val Asp Ile Tyr Asn Cys Val Arg Glu Leu Arg Ser Arg Arg Val Asn
                1125                1130                1135    
Met Val Gln Thr Glu Glu Gln Tyr Val Phe Ile His Asp Ala Ile Leu
            1140                1145                1150        
Glu Ala Cys Leu Cys Gly Asp Thr Ser Val Pro Ala Ser Gln Val Arg
        1155                1160                1165            
Ser Leu Tyr Tyr Asp Met Asn Lys Leu Asp Pro Gln Thr Asn Ser Ser
    1170                1175                1180                
Gln Ile Lys Glu Glu Phe Arg Thr Leu Asn Met Val Thr Pro Thr Leu
1185                1190                1195                1200
Arg Val Glu Asp Cys Ser Ile Ala Leu Leu Pro Arg Asn His Glu Lys
                1205                1210                1215    
Asn Arg Cys Met Asp Ile Leu Pro Pro Asp Arg Cys Leu Pro Phe Leu
            1220                1225                1230        
Ile Thr Ile Asp Gly Glu Ser Ser Asn Tyr Ile Asn Ala Ala Leu Met
        1235                1240                1245            
Asp Ser Tyr Lys Gln Pro Ser Ala Phe Ile Val Thr Gln His Pro Leu
    1250                1255                1260                
Pro Asn Thr Val Lys Asp Phe Trp Arg Leu Val Leu Asp Tyr His Cys
1265                1270                1275                1280
Thr Ser Val Val Met Leu Asn Asp Val Asp Pro Ala Gln Leu Cys Pro
                1285                1290                1295    
Gln Tyr Trp Pro Glu Asn Gly Val His Arg His Gly Pro Ile Gln Val
            1300                1305                1310        
Glu Phe Val Ser Ala Asp Leu Glu Glu Asp Ile Ile Ser Arg Ile Phe
        1315                1320                1325            
Arg Ile Tyr Asn Ala Ala Arg Pro Gln Asp Gly Tyr Arg Met Val Gln
    1330                1335                1340                
Gln Phe Gln Phe Leu Gly Trp Pro Met Tyr Arg Asp Thr Pro Val Ser
1345                1350                1355                1360
Lys Arg Ser Phe Leu Lys Leu Ile Arg Gln Val Asp Lys Trp Gln Glu
                1365                1370                1375    
Glu Tyr Asn Gly Gly Glu Gly Pro Thr Val Val His Cys Leu Asn Gly
            1380                1385                1390        
Gly Gly Arg Ser Gly Thr Phe Cys Ala Ile Ser Ile Val Cys Glu Met
        1395                1400                1405            
Leu Arg His Gln Arg Thr Val Asp Val Phe His Ala Val Lys Thr Leu
    1410                1415                1420                
Arg Asn Asn Lys Pro Asn Met Val Asp Leu Leu Asp Gln Tyr Lys Phe
1425                1430                1435                1440
Cys Tyr Glu Val Ala Leu Glu Tyr Leu Asn Ser Gly
                1445                1450        


<210> 8813
<211> 179
<212> PRT
<213> Homo sapiens

<400> 8813
His Phe Gly Leu Trp Ser Val Leu Met Val Leu Ile Leu Asn Ser Thr
 1               5                  10                  15      
Leu Phe Phe Phe Gln Asn Leu Ser Ser Tyr Cys His Ser Gln Ile Asn
            20                  25                  30          
Ser Thr Leu Lys Gly Arg Trp Arg Val Ser Pro Ser His Arg Ala Leu
        35                  40                  45              
Ala Leu Leu Leu Cys Leu Leu Thr Pro Pro Phe Thr His Ser Ile Arg
    50                  55                  60                  
Glu Leu Leu Pro Leu Asn Arg Gly Ala Ala Leu Asp Gln Ala His Arg
65                  70                  75                  80  
Asp Val Ala Asp Gln Trp Ala Gly Gly Cys Val Pro Gly Lys Pro Gly
                85                  90                  95      
Arg Gln Pro Gly Arg Gln Gln Ala Arg Pro Leu Pro Thr Gln Gln Ser
            100                 105                 110         
Cys Gly Gly Leu His Ala His Pro Pro Leu Leu Gly Val Cys Phe Ile
        115                 120                 125             
Phe Leu Tyr Phe Gln Asn Glu His Pro Pro Asp Ser Leu Pro Gly Met
    130                 135                 140                 
Ile Asp Ala Gly Gly Gly Ser Phe Ser Gln Ser Leu Ala Ser Asp Pro
145                 150                 155                 160 
Ala Ser Arg Gly Arg Arg Gly Phe Cys Ala Pro Ala Gly Gly Arg Ser
                165                 170                 175     
Gly Met Cys
            


<210> 8814
<211> 349
<212> PRT
<213> Homo sapiens

<400> 8814
Met Asn Arg Lys Ala Leu Arg Cys Leu Gly His Leu Phe Leu Ser Leu
 1               5                  10                  15      
Gly Met Val Cys Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu
            20                  25                  30          
Gly Ala Thr Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln
        35                  40                  45              
Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu
    50                  55                  60                  
Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly
65                  70                  75                  80  
Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu
                85                  90                  95      
Leu Lys Val Gly Ser Arg Asp Gly Ala Phe Thr Tyr Ala Ile Ile Ala
            100                 105                 110         
Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr His Gly Asn Leu
        115                 120                 125             
Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp
    130                 135                 140                 
Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile
145                 150                 155                 160 
Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala
                165                 170                 175     
Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu
            180                 185                 190         
Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser
        195                 200                 205             
Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu
    210                 215                 220                 
Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro
225                 230                 235                 240 
Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys
                245                 250                 255     
Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu
            260                 265                 270         
Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly
        275                 280                 285             
Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys
    290                 295                 300                 
Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg
305                 310                 315                 320 
Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys
                325                 330                 335     
Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys
            340                 345                 


<210> 8815
<211> 525
<212> PRT
<213> Homo sapiens

<400> 8815
Met Gly Trp Leu Phe Leu Lys Val Leu Leu Ala Gly Val Ser Phe Ser
 1               5                  10                  15      
Gly Phe Leu Tyr Pro Leu Val Asp Phe Cys Ile Ser Gly Lys Thr Arg
            20                  25                  30          
Gly Gln Lys Pro Asn Phe Val Ile Ile Leu Ala Asp Asp Met Gly Trp
        35                  40                  45              
Gly Asp Leu Gly Ala Asn Trp Ala Glu Thr Lys Asp Thr Ala Asn Leu
    50                  55                  60                  
Asp Lys Met Ala Ser Glu Gly Met Arg Phe Val Asp Phe His Ala Ala
65                  70                  75                  80  
Ala Ser Thr Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Arg Leu
                85                  90                  95      
Gly Leu Arg Asn Gly Val Thr Arg Asn Phe Ala Val Thr Ser Val Gly
            100                 105                 110         
Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Glu Val Leu Gln Gln Ala
        115                 120                 125             
Gly Tyr Val Thr Gly Ile Ile Gly Lys Trp His Leu Gly His His Gly
    130                 135                 140                 
Ser Tyr His Pro Asn Phe Arg Gly Phe Asp Tyr Tyr Phe Gly Ile Pro
145                 150                 155                 160 
Tyr Ser His Asp Met Gly Cys Thr Asp Thr Pro Gly Tyr Asn His Pro
                165                 170                 175     
Pro Cys Pro Ala Cys Pro Gln Gly Asp Gly Pro Ser Arg Asn Leu Gln
            180                 185                 190         
Arg Asp Cys Tyr Thr Asp Val Ala Leu Pro Leu Tyr Glu Asn Leu Asn
        195                 200                 205             
Ile Val Glu Gln Pro Val Asn Leu Ser Ser Leu Ala Gln Lys Tyr Ala
    210                 215                 220                 
Glu Lys Ala Thr Gln Phe Ile Gln Arg Ala Ser Thr Ser Gly Arg Pro
225                 230                 235                 240 
Phe Leu Leu Tyr Val Ala Leu Ala His Met His Val Pro Leu Pro Val
                245                 250                 255     
Thr Gln Leu Pro Ala Ala Pro Arg Gly Arg Ser Leu Tyr Gly Ala Gly
            260                 265                 270         
Leu Trp Glu Met Asp Ser Leu Val Gly Gln Ile Lys Asp Lys Val Asp
        275                 280                 285             
His Thr Val Lys Glu Asn Thr Phe Leu Trp Phe Thr Gly Asp Asn Gly
    290                 295                 300                 
Pro Trp Ala Gln Lys Cys Glu Leu Ala Gly Ser Val Gly Pro Phe Thr
305                 310                 315                 320 
Gly Phe Trp Gln Thr Arg Gln Gly Gly Ser Pro Ala Lys Gln Thr Thr
                325                 330                 335     
Trp Glu Gly Gly His Arg Val Pro Ala Leu Ala Tyr Trp Pro Gly Arg
            340                 345                 350         
Val Pro Val Asn Val Thr Ser Thr Ala Leu Leu Ser Val Leu Asp Ile
        355                 360                 365             
Phe Pro Thr Val Val Ala Leu Ala Gln Ala Ser Leu Pro Gln Gly Arg
    370                 375                 380                 
Arg Phe Asp Gly Val Asp Val Ser Glu Val Leu Phe Gly Arg Ser Gln
385                 390                 395                 400 
Pro Gly His Arg Val Leu Phe His Pro Asn Ser Gly Ala Ala Gly Glu
                405                 410                 415     
Phe Gly Ala Leu Gln Thr Val Arg Leu Glu Arg Tyr Lys Ala Phe Tyr
            420                 425                 430         
Ile Thr Gly Gly Ala Arg Ala Cys Asp Gly Ser Thr Gly Pro Glu Leu
        435                 440                 445             
Gln His Lys Phe Pro Leu Ile Phe Asn Leu Glu Asp Asp Thr Ala Glu
    450                 455                 460                 
Ala Val Pro Leu Glu Arg Gly Gly Ala Glu Tyr Gln Ala Val Leu Pro
465                 470                 475                 480 
Glu Val Arg Lys Val Leu Ala Asp Val Leu Gln Asp Ile Ala Asn Asp
                485                 490                 495     
Asn Ile Ser Ser Pro Asp Tyr Thr Gln Asp Pro Ser Val Thr Pro Cys
            500                 505                 510         
Cys Asn Pro Tyr Gln Ile Ala Cys Arg Cys Gln Ala Ala
        515                 520                 525 


<210> 8816
<211> 255
<212> PRT
<213> Homo sapiens

<400> 8816
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu
 1               5                  10                  15      
Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro
            20                  25                  30          
Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys
        35                  40                  45              
Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile
    50                  55                  60                  
Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser
65                  70                  75                  80  
Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly
                85                  90                  95      
Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu
            100                 105                 110         
Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln
        115                 120                 125             
Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys
    130                 135                 140                 
Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro
145                 150                 155                 160 
Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala
                165                 170                 175     
Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu
            180                 185                 190         
Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu
        195                 200                 205             
Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
    210                 215                 220                 
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
225                 230                 235                 240 
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
                245                 250                 255 


<210> 8817
<211> 616
<212> PRT
<213> Homo sapiens

<400> 8817
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu
 1               5                  10                  15      
Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro
            20                  25                  30          
Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn
        35                  40                  45              
Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser
    50                  55                  60                  
Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp
65                  70                  75                  80  
Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys
                85                  90                  95      
Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys
            100                 105                 110         
Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg
        115                 120                 125             
Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln
    130                 135                 140                 
Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser
145                 150                 155                 160 
Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr
                165                 170                 175     
Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala
            180                 185                 190         
Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His
        195                 200                 205             
Val Tyr Leu Pro Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala
    210                 215                 220                 
Leu Val Ala Ala Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys
225                 230                 235                 240 
Ala Leu Thr Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg
                245                 250                 255     
Leu Ser Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His
            260                 265                 270         
Thr Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu
        275                 280                 285             
Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp Gln
    290                 295                 300                 
Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr Ala Gln
305                 310                 315                 320 
Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr Glu Ile Glu
                325                 330                 335     
Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu Tyr Met Asp Arg
            340                 345                 350         
Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu Thr Glu Pro Gly Ser
        355                 360                 365             
Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu Glu Val Gly Glu Asn Asp
    370                 375                 380                 
Ser Leu Ser Gln Cys Phe Thr Gly Thr Gln Ser Thr Val Gly Ser Glu
385                 390                 395                 400 
Ser Cys Asn Cys Thr Glu Pro Leu Cys Arg Thr Asp Trp Thr Pro Met
                405                 410                 415     
Ser Ser Glu Asn Tyr Leu Gln Lys Glu Val Asp Ser Gly His Cys Pro
            420                 425                 430         
His Trp Ala Ala Ser Pro Ser Pro Asn Trp Ala Asp Val Cys Thr Gly
        435                 440                 445             
Cys Arg Asn Pro Pro Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro
    450                 455                 460                 
Lys Arg Gly Pro Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro
465                 470                 475                 480 
Glu Glu Glu Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly
                485                 490                 495     
Ala Asp Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly
            500                 505                 510         
Ser Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn
        515                 520                 525             
Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys Gly
    530                 535                 540                 
Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly Ala Ala
545                 550                 555                 560 
Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu Thr Leu Ala
                565                 570                 575     
Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe Pro Asp Pro Cys
            580                 585                 590         
Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys Ala Ser Arg Pro Val
        595                 600                 605             
Gln Glu Gln Gly Gly Ala Lys Ala
    610                 615     


<210> 8818
<211> 374
<212> PRT
<213> Homo sapiens

<400> 8818
Met Ala Ala Ser Ala Ala Ala Ala Glu Leu Gln Ala Ser Gly Gly Pro
 1               5                  10                  15      
Arg His Pro Val Cys Leu Leu Val Leu Gly Met Ala Gly Ser Gly Lys
            20                  25                  30          
Thr Thr Phe Val Gln Arg Leu Thr Gly His Leu His Ala Gln Gly Thr
        35                  40                  45              
Pro Pro Tyr Val Ile Asn Leu Asp Pro Ala Val His Glu Val Pro Phe
    50                  55                  60                  
Pro Ala Asn Ile Asp Ile Arg Asp Thr Val Lys Tyr Lys Glu Val Met
65                  70                  75                  80  
Lys Gln Tyr Gly Leu Gly Pro Asn Gly Gly Ile Val Thr Ser Leu Asn
                85                  90                  95      
Leu Phe Ala Thr Arg Phe Asp Gln Val Met Lys Phe Ile Glu Lys Ala
            100                 105                 110         
Gln Asn Met Ser Lys Tyr Val Leu Ile Asp Thr Pro Gly Gln Ile Glu
        115                 120                 125             
Val Phe Thr Trp Ser Ala Ser Gly Thr Ile Ile Thr Glu Ala Leu Ala
    130                 135                 140                 
Ser Ser Phe Pro Thr Val Val Ile Tyr Val Met Asp Thr Ser Arg Ser
145                 150                 155                 160 
Thr Asn Pro Val Thr Phe Met Ser Asn Met Leu Tyr Ala Cys Ser Ile
                165                 170                 175     
Leu Tyr Lys Thr Lys Leu Pro Phe Ile Val Val Met Asn Lys Thr Asp
            180                 185                 190         
Ile Ile Asp His Ser Phe Ala Val Glu Trp Met Gln Asp Phe Glu Ala
        195                 200                 205             
Phe Gln Asp Ala Leu Asn Gln Glu Thr Thr Tyr Val Ser Asn Leu Thr
    210                 215                 220                 
Arg Ser Met Ser Leu Val Leu Asp Glu Phe Tyr Ser Ser Leu Arg Val
225                 230                 235                 240 
Val Gly Val Ser Ala Val Leu Gly Thr Gly Leu Asp Glu Leu Phe Val
                245                 250                 255     
Gln Val Thr Ser Ala Ala Glu Glu Tyr Glu Arg Glu Tyr Arg Pro Glu
            260                 265                 270         
Tyr Glu Arg Leu Lys Lys Ser Leu Ala Asn Ala Glu Ser Gln Gln Gln
        275                 280                 285             
Arg Glu Gln Leu Glu Arg Leu Arg Lys Asp Met Gly Ser Val Ala Leu
    290                 295                 300                 
Asp Ala Gly Thr Ala Lys Asp Ser Leu Ser Pro Val Leu His Pro Ser
305                 310                 315                 320 
Asp Leu Ile Leu Thr Arg Gly Thr Leu Asp Glu Glu Asp Glu Glu Ala
                325                 330                 335     
Asp Ser Asp Thr Asp Asp Ile Asp His Arg Val Thr Glu Glu Ser His
            340                 345                 350         
Glu Glu Pro Ala Phe Gln Asn Phe Met Gln Glu Ser Met Ala Gln Tyr
        355                 360                 365             
Trp Lys Arg Asn Asn Lys
    370                 


<210> 8819
<211> 832
<212> PRT
<213> Homo sapiens

<400> 8819
Met Lys Pro Pro Gly Ser Ser Ser Arg Gln Pro Pro Leu Ala Gly Cys
 1               5                  10                  15      
Ser Leu Ala Gly Ala Ser Cys Gly Pro Gln Arg Gly Pro Ala Gly Ser
            20                  25                  30          
Val Pro Ala Ser Ala Pro Ala Arg Thr Pro Pro Cys Arg Leu Leu Leu
        35                  40                  45              
Val Leu Leu Leu Leu Pro Pro Leu Ala Ala Ser Ser Arg Pro Arg Ala
    50                  55                  60                  
Trp Gly Ala Ala Ala Pro Ser Ala Pro His Trp Asn Glu Thr Ala Glu
65                  70                  75                  80  
Lys Asn Leu Gly Val Leu Ala Asp Glu Asp Asn Thr Leu Gln Gln Asn
                85                  90                  95      
Ser Ser Ser Asn Ile Ser Tyr Ser Asn Ala Met Gln Lys Glu Ile Thr
            100                 105                 110         
Leu Pro Ser Arg Leu Ile Tyr Tyr Ile Asn Gln Asp Ser Glu Ser Pro
        115                 120                 125             
Tyr His Val Leu Asp Thr Lys Ala Arg His Gln Gln Lys His Asn Lys
    130                 135                 140                 
Ala Val His Leu Ala Gln Ala Ser Phe Gln Ile Glu Ala Phe Gly Ser
145                 150                 155                 160 
Lys Phe Ile Leu Asp Leu Ile Leu Asn Asn Gly Leu Leu Ser Ser Asp
                165                 170                 175     
Tyr Val Glu Ile His Tyr Glu Asn Gly Lys Pro Gln Tyr Ser Lys Gly
            180                 185                 190         
Gly Glu His Cys Tyr Tyr His Gly Ser Ile Arg Gly Val Lys Asp Ser
        195                 200                 205             
Lys Val Ala Leu Ser Thr Cys Asn Gly Leu His Gly Met Phe Glu Asp
    210                 215                 220                 
Asp Thr Phe Val Tyr Met Ile Glu Pro Leu Glu Leu Val His Asp Glu
225                 230                 235                 240 
Lys Ser Thr Gly Arg Pro His Ile Ile Gln Lys Thr Leu Ala Gly Gln
                245                 250                 255     
Tyr Ser Lys Gln Met Lys Asn Leu Thr Met Glu Arg Gly Asp Gln Trp
            260                 265                 270         
Pro Phe Leu Ser Glu Leu Gln Trp Leu Lys Arg Arg Lys Arg Ala Val
        275                 280                 285             
Asn Pro Ser Arg Gly Ile Phe Glu Glu Met Lys Tyr Leu Glu Leu Met
    290                 295                 300                 
Ile Val Asn Asp His Lys Thr Tyr Lys Lys His Arg Ser Ser His Ala
305                 310                 315                 320 
His Thr Asn Asn Phe Ala Lys Ser Val Val Asn Leu Val Asp Ser Ile
                325                 330                 335     
Tyr Lys Glu Gln Leu Asn Thr Arg Val Val Leu Val Ala Val Glu Thr
            340                 345                 350         
Trp Thr Glu Lys Asp Gln Ile Asp Ile Thr Thr Asn Pro Val Gln Met
        355                 360                 365             
Leu His Glu Phe Ser Lys Tyr Arg Gln Arg Ile Lys Gln His Ala Asp
    370                 375                 380                 
Ala Val His Leu Ile Ser Arg Val Thr Phe His Tyr Lys Arg Ser Ser
385                 390                 395                 400 
Leu Ser Tyr Phe Gly Gly Val Cys Ser Arg Thr Arg Gly Val Gly Val
                405                 410                 415     
Asn Glu Tyr Gly Leu Pro Met Ala Val Ala Gln Val Leu Ser Gln Ser
            420                 425                 430         
Leu Ala Gln Asn Leu Gly Ile Gln Trp Glu Pro Ser Ser Arg Lys Pro
        435                 440                 445             
Lys Cys Asp Cys Thr Glu Ser Trp Gly Gly Cys Ile Met Glu Glu Thr
    450                 455                 460                 
Gly Val Ser His Ser Arg Lys Phe Ser Lys Cys Ser Ile Leu Glu Tyr
465                 470                 475                 480 
Arg Asp Phe Leu Gln Arg Gly Gly Gly Ala Cys Leu Phe Asn Arg Pro
                485                 490                 495     
Thr Lys Leu Phe Glu Pro Thr Glu Cys Gly Asn Gly Tyr Val Glu Ala
            500                 505                 510         
Gly Glu Glu Cys Asp Cys Gly Phe His Val Glu Cys Tyr Gly Leu Cys
        515                 520                 525             
Cys Lys Lys Cys Ser Leu Ser Asn Gly Ala His Cys Ser Asp Gly Pro
    530                 535                 540                 
Cys Cys Asn Asn Thr Ser Cys Leu Phe Gln Pro Arg Gly Tyr Glu Cys
545                 550                 555                 560 
Arg Asp Ala Val Asn Glu Cys Asp Ile Thr Glu Tyr Cys Thr Gly Asp
                565                 570                 575     
Ser Gly Gln Cys Pro Pro Asn Leu His Lys Gln Asp Gly Tyr Ala Cys
            580                 585                 590         
Asn Gln Asn Gln Gly Arg Cys Tyr Asn Gly Glu Cys Lys Thr Arg Asp
        595                 600                 605             
Asn Gln Cys Gln Tyr Ile Trp Gly Thr Lys Ala Ala Gly Ser Asp Lys
    610                 615                 620                 
Phe Cys Tyr Glu Lys Leu Asn Thr Glu Gly Thr Glu Lys Gly Asn Cys
625                 630                 635                 640 
Gly Lys Asp Gly Asp Arg Trp Ile Gln Cys Ser Lys His Asp Val Phe
                645                 650                 655     
Cys Gly Phe Leu Leu Cys Thr Asn Leu Thr Arg Ala Pro Arg Ile Gly
            660                 665                 670         
Gln Leu Gln Gly Glu Ile Ile Pro Thr Ser Phe Tyr His Gln Gly Arg
        675                 680                 685             
Val Ile Asp Cys Ser Gly Ala His Val Val Leu Asp Asp Asp Thr Asp
    690                 695                 700                 
Val Gly Tyr Val Glu Asp Gly Thr Pro Cys Gly Pro Ser Met Met Cys
705                 710                 715                 720 
Leu Asp Arg Lys Cys Leu Gln Ile Gln Ala Leu Asn Met Ser Ser Cys
                725                 730                 735     
Pro Leu Asp Ser Lys Gly Lys Val Cys Ser Gly His Gly Val Cys Ser
            740                 745                 750         
Asn Glu Ala Thr Cys Ile Cys Asp Phe Thr Trp Ala Gly Thr Asp Cys
        755                 760                 765             
Ser Ile Arg Asp Pro Val Arg Asn Leu His Pro Pro Lys Asp Glu Gly
    770                 775                 780                 
Pro Lys Gly Pro Ser Ala Thr Asn Leu Ile Ile Gly Ser Ile Ala Gly
785                 790                 795                 800 
Ala Ile Leu Val Ala Ala Ile Val Leu Gly Gly Thr Gly Trp Gly Phe
                805                 810                 815     
Lys Asn Val Lys Lys Arg Arg Phe Asp Pro Thr Gln Gln Gly Pro Ile
            820                 825                 830         


<210> 8820
<211> 361
<212> PRT
<213> Homo sapiens

<400> 8820
Val Ile Lys Cys Lys Ala Ala Val Leu Trp Glu Leu Lys Lys Pro Phe
 1               5                  10                  15      
Ser Ile Glu Glu Val Glu Val Ala Pro Pro Lys Ala His Glu Val Arg
            20                  25                  30          
Ile Lys Met Val Ala Val Gly Ile Cys His Thr Asp Asp His Val Val
        35                  40                  45              
Ser Gly Asn Leu Val Thr Pro Leu Pro Val Ile Leu Gly His Glu Ala
    50                  55                  60                  
Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val Thr Thr Val Lys Pro
65                  70                  75                  80  
Gly Asp Lys Val Ile Pro Leu Phe Thr Pro Gln Cys Gly Lys Cys Arg
                85                  90                  95      
Val Cys Lys Asn Pro Glu Ser Asn Tyr Cys Leu Lys Asn Asp Leu Gly
            100                 105                 110         
Asn Pro Arg Gly Thr Leu Gln Asp Gly Thr Arg Arg Phe Thr Cys Arg
        115                 120                 125             
Gly Lys Pro Ile His His Phe Leu Gly Thr Ser Thr Phe Ser Gln Tyr
    130                 135                 140                 
Thr Val Val Asp Glu Asn Ala Val Ala Lys Ile Asp Ala Ala Ser Pro
145                 150                 155                 160 
Leu Glu Lys Val Cys Leu Ile Gly Cys Gly Phe Ser Thr Gly Tyr Gly
                165                 170                 175     
Ser Ala Val Asn Val Ala Lys Val Thr Pro Gly Ser Thr Cys Ala Val
            180                 185                 190         
Phe Gly Leu Gly Gly Val Gly Leu Ser Ala Ile Met Gly Cys Lys Ala
        195                 200                 205             
Ala Gly Ala Ala Arg Ile Ile Ala Val Asp Ile Asn Lys Asp Lys Phe
    210                 215                 220                 
Ala Lys Ala Lys Glu Leu Gly Ala Thr Glu Cys Ile Asn Pro Gln Asp
225                 230                 235                 240 
Tyr Lys Lys Pro Ile Gln Glu Val Leu Lys Glu Met Thr Asp Gly Gly
                245                 250                 255     
Val Asp Phe Ser Phe Glu Val Ile Gly Arg Leu Asp Thr Met Met Ala
            260                 265                 270         
Ser Leu Leu Cys Cys His Glu Ala Cys Gly Thr Ser Val Ile Val Gly
        275                 280                 285             
Val Pro Pro Asp Ser Gln Asn Leu Ser Met Asn Pro Met Leu Leu Leu
    290                 295                 300                 
Thr Gly Arg Thr Trp Lys Gly Ala Ile Leu Gly Gly Phe Lys Ser Lys
305                 310                 315                 320 
Glu Cys Val Pro Lys Leu Val Ala Asp Phe Met Ala Lys Lys Phe Ser
                325                 330                 335     
Leu Asp Ala Leu Ile Thr His Val Leu Pro Phe Glu Lys Ile Asn Glu
            340                 345                 350         
Gly Phe Asp Leu Leu His Ser Gly Lys
        355                 360     


<210> 8821
<211> 375
<212> PRT
<213> Homo sapiens

<400> 8821
Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp
 1               5                  10                  15      
Glu Leu Lys Lys Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro
            20                  25                  30          
Lys Ala His Glu Val Arg Ile Lys Met Val Ala Val Gly Ile Cys Gly
        35                  40                  45              
Thr Asp Asp His Val Val Ser Gly Thr Met Val Thr Pro Leu Pro Val
    50                  55                  60                  
Ile Leu Gly His Glu Ala Ala Gly Ile Val Glu Ser Val Gly Glu Gly
65                  70                  75                  80  
Val Thr Thr Val Lys Pro Gly Asp Lys Val Ile Pro Leu Ala Ile Pro
                85                  90                  95      
Gln Cys Gly Lys Cys Arg Ile Cys Lys Asn Pro Glu Ser Asn Tyr Cys
            100                 105                 110         
Leu Lys Asn Asp Val Ser Asn Pro Gln Gly Thr Leu Gln Asp Gly Thr
        115                 120                 125             
Ser Arg Phe Thr Cys Arg Arg Lys Pro Ile His His Phe Leu Gly Ile
    130                 135                 140                 
Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Asn Ala Val Ala Lys
145                 150                 155                 160 
Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly
                165                 170                 175     
Phe Ser Thr Gly Tyr Gly Ser Ala Val Asn Val Ala Lys Val Thr Pro
            180                 185                 190         
Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Ala
        195                 200                 205             
Ile Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Ala Val Asp
    210                 215                 220                 
Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Leu Gly Ala Thr Glu
225                 230                 235                 240 
Cys Ile Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Lys
                245                 250                 255     
Glu Met Thr Asp Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg
            260                 265                 270         
Leu Asp Thr Met Met Ala Ser Leu Leu Cys Cys His Glu Ala Cys Gly
        275                 280                 285             
Thr Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met
    290                 295                 300                 
Asn Pro Met Leu Leu Leu Thr Gly Arg Thr Trp Lys Gly Ala Ile Leu
305                 310                 315                 320 
Gly Gly Phe Lys Ser Lys Glu Cys Val Pro Lys Leu Val Ala Asp Phe
                325                 330                 335     
Met Ala Lys Lys Phe Ser Leu Asp Ala Leu Ile Thr His Val Leu Pro
            340                 345                 350         
Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu His Ser Gly Lys Ser
        355                 360                 365             
Ile Arg Thr Ile Leu Met Phe
    370                 375 


<210> 8822
<211> 314
<212> PRT
<213> Homo sapiens

<400> 8822
Val Ser Gly Asn Leu Val Thr Pro Leu Pro Val Ile Leu Gly His Glu
 1               5                  10                  15      
Ala Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val Thr Thr Val Lys
            20                  25                  30          
Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro Gln Cys Gly Lys Cys
        35                  40                  45              
Arg Val Cys Lys Asn Pro Glu Ser Asn Tyr Cys Leu Lys Asn Asp Leu
    50                  55                  60                  
Gly Asn Pro Arg Gly Thr Leu Gln Asp Gly Thr Arg Arg Phe Thr Cys
65                  70                  75                  80  
Arg Gly Lys Pro Ile His His Phe Leu Gly Thr Ser Thr Phe Ser Gln
                85                  90                  95      
Tyr Thr Val Val Asp Glu Asn Ala Val Ala Lys Ile Asp Ala Ala Ser
            100                 105                 110         
Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly Phe Ser Thr Gly Tyr
        115                 120                 125             
Gly Ser Ala Val Asn Val Ala Lys Val Thr Pro Gly Ser Thr Cys Ala
    130                 135                 140                 
Val Phe Gly Leu Gly Gly Val Gly Leu Ser Ala Val Met Gly Cys Lys
145                 150                 155                 160 
Ala Ala Gly Ala Ala Arg Ile Ile Ala Val Asp Ile Asn Lys Asp Lys
                165                 170                 175     
Phe Ala Lys Ala Lys Glu Leu Gly Ala Thr Glu Cys Ile Asn Pro Gln
            180                 185                 190         
Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Lys Glu Met Thr Asp Gly
        195                 200                 205             
Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg Leu Asp Thr Met Met
    210                 215                 220                 
Ala Ser Leu Leu Cys Cys His Glu Ala Cys Gly Thr Ser Val Ile Val
225                 230                 235                 240 
Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met Asn Pro Met Leu Leu
                245                 250                 255     
Leu Thr Gly Arg Thr Trp Lys Gly Ala Ile Leu Gly Gly Phe Lys Ser
            260                 265                 270         
Lys Glu Cys Val Pro Lys Leu Val Ala Asp Phe Met Ala Lys Lys Phe
        275                 280                 285             
Ser Leu Asp Ala Leu Ile Thr His Val Leu Pro Phe Glu Lys Ile Asn
    290                 295                 300                 
Glu Gly Phe Asp Leu Leu His Ser Gly Lys
305                 310                 


<210> 8823
<211> 627
<212> PRT
<213> Homo sapiens

<400> 8823
Met Glu Gly Leu Ala Gly Tyr Val Tyr Lys Ala Ala Ser Glu Gly Lys
 1               5                  10                  15      
Val Leu Thr Leu Ala Ala Leu Leu Leu Asn Arg Ser Glu Ser Asp Ile
            20                  25                  30          
Arg Tyr Leu Leu Gly Tyr Val Ser Gln Gln Gly Gly Gln Arg Ser Thr
        35                  40                  45              
Pro Leu Ile Ile Ala Ala Arg Asn Gly His Ala Lys Val Val Arg Leu
    50                  55                  60                  
Leu Leu Glu His Tyr Arg Val Gln Thr Gln Gln Thr Gly Thr Val Arg
65                  70                  75                  80  
Phe Asp Gly Tyr Val Ile Asp Gly Ala Thr Ala Leu Trp Cys Ala Ala
                85                  90                  95      
Gly Ala Gly His Phe Glu Val Val Lys Leu Leu Val Ser His Gly Ala
            100                 105                 110         
Asn Val Asn His Thr Thr Val Thr Asn Ser Thr Pro Leu Arg Ala Ala
        115                 120                 125             
Cys Phe Asp Gly Arg Leu Asp Ile Val Lys Tyr Leu Val Glu Asn Asn
    130                 135                 140                 
Ala Asn Ile Ser Ile Ala Asn Lys Tyr Asp Asn Thr Cys Leu Met Ile
145                 150                 155                 160 
Ala Ala Tyr Lys Gly His Thr Asp Val Val Arg Tyr Leu Leu Glu Gln
                165                 170                 175     
Arg Ala Asp Pro Asn Ala Lys Ala His Cys Gly Ala Thr Ala Leu His
            180                 185                 190         
Phe Ala Ala Glu Ala Gly His Ile Asp Ile Val Lys Glu Leu Ile Lys
        195                 200                 205             
Trp Arg Ala Ala Ile Val Val Asn Gly His Gly Met Thr Pro Leu Lys
    210                 215                 220                 
Val Ala Ala Glu Ser Cys Lys Ala Asp Val Val Glu Leu Leu Leu Ser
225                 230                 235                 240 
His Ala Asp Cys Asp Arg Arg Ser Arg Ile Glu Ala Leu Glu Leu Leu
                245                 250                 255     
Gly Ala Ser Phe Ala Asn Asp Arg Glu Asn Tyr Asp Ile Ile Lys Thr
            260                 265                 270         
Tyr His Tyr Leu Tyr Leu Ala Met Leu Glu Arg Phe Gln Asp Gly Asp
        275                 280                 285             
Asn Ile Leu Glu Lys Glu Val Leu Pro Pro Ile His Ala Tyr Gly Asn
    290                 295                 300                 
Arg Thr Glu Cys Arg Asn Pro Gln Glu Leu Glu Ser Ile Arg Gln Asp
305                 310                 315                 320 
Arg Asp Ala Leu His Met Glu Gly Leu Ile Val Arg Glu Arg Ile Leu
                325                 330                 335     
Gly Ala Asp Asn Ile Asp Val Ser His Pro Ile Ile Tyr Arg Gly Ala
            340                 345                 350         
Val Tyr Ala Asp Asn Met Glu Phe Glu Gln Cys Ile Lys Leu Trp Leu
        355                 360                 365             
His Ala Leu His Leu Arg Gln Lys Gly Asn Arg Asn Thr His Lys Asp
    370                 375                 380                 
Leu Leu Arg Phe Ala Gln Val Phe Ser Gln Met Ile His Leu Asn Glu
385                 390                 395                 400 
Thr Val Lys Ala Pro Asp Ile Glu Cys Val Leu Arg Cys Ser Val Leu
                405                 410                 415     
Glu Ile Glu Gln Ser Met Asn Arg Val Lys Asn Ile Ser Asp Ala Asp
            420                 425                 430         
Val His Asn Ala Met Asp Asn Tyr Glu Cys Asn Leu Tyr Thr Phe Leu
        435                 440                 445             
Tyr Leu Val Cys Ile Ser Thr Lys Thr Gln Cys Ser Glu Glu Asp Gln
    450                 455                 460                 
Cys Lys Ile Asn Lys Gln Ile Tyr Asn Leu Ile His Leu Asp Pro Arg
465                 470                 475                 480 
Thr Arg Glu Gly Phe Thr Leu Leu His Leu Ala Val Asn Ser Asn Thr
                485                 490                 495     
Pro Val Asp Asp Phe His Thr Asn Asp Val Cys Ser Phe Pro Asn Ala
            500                 505                 510         
Leu Val Thr Lys Leu Leu Leu Asp Cys Gly Ala Glu Val Asn Ala Val
        515                 520                 525             
Asp Asn Glu Gly Asn Ser Ala Leu His Ile Ile Val Gln Tyr Asn Arg
    530                 535                 540                 
Pro Ile Ser Asp Phe Leu Thr Leu His Ser Ile Ile Ile Ser Leu Val
545                 550                 555                 560 
Glu Ala Gly Ala His Thr Asp Met Thr Asn Lys Gln Asn Lys Thr Pro
                565                 570                 575     
Leu Asp Lys Ser Thr Thr Gly Val Ser Glu Ile Leu Leu Lys Thr Gln
            580                 585                 590         
Met Lys Met Ser Leu Lys Cys Leu Ala Ala Arg Ala Val Arg Ala Asn
        595                 600                 605             
Asp Ile Asn Tyr Gln Asp Gln Ile Pro Arg Thr Leu Glu Glu Phe Val
    610                 615                 620                 
Gly Phe His
625         


<210> 8824
<211> 476
<212> PRT
<213> Homo sapiens

<400> 8824
Met Glu Thr Pro Gly Ala Ser Ala Ser Ser Leu Leu Leu Pro Ala Ala
 1               5                  10                  15      
Ser Arg Pro Pro Arg Lys Arg Glu Ala Gly Glu Ala Gly Ala Ala Thr
            20                  25                  30          
Ser Lys Gln Arg Val Leu Asp Glu Glu Glu Tyr Ile Glu Gly Leu Gln
        35                  40                  45              
Thr Val Ile Gln Arg Asp Phe Phe Pro Asp Val Glu Lys Leu Gln Ala
    50                  55                  60                  
Gln Lys Glu Tyr Leu Glu Ala Glu Glu Asn Gly Asp Leu Glu Arg Met
65                  70                  75                  80  
Arg Gln Ile Ala Ile Lys Phe Gly Ser Ala Leu Gly Lys Met Ser Arg
                85                  90                  95      
Glu Pro Pro Pro Pro Tyr Val Thr Pro Ala Thr Phe Glu Thr Pro Glu
            100                 105                 110         
Val His Ala Gly Thr Gly Val Val Gly Asn Lys Pro Arg Pro Arg Gly
        115                 120                 125             
Arg Gly Leu Glu Asp Gly Glu Ala Gly Glu Glu Glu Glu Lys Glu Pro
    130                 135                 140                 
Leu Pro Ser Leu Asp Val Phe Leu Ser Arg Tyr Thr Ser Glu Asp Asn
145                 150                 155                 160 
Ala Ser Phe Gln Glu Ile Met Glu Val Ala Lys Glu Arg Ser Arg Ala
                165                 170                 175     
Arg His Ala Trp Leu Tyr Gln Ala Glu Glu Glu Phe Glu Lys Arg Gln
            180                 185                 190         
Lys Asp Asn Leu Glu Leu Pro Ser Ala Glu His Gln Ala Ile Glu Ser
        195                 200                 205             
Ser Gln Ala Ser Val Glu Thr Trp Lys Tyr Lys Ala Lys Asn Ser Leu
    210                 215                 220                 
Met Tyr Tyr Pro Glu Gly Val Pro Asp Glu Glu Gln Leu Phe Lys Lys
225                 230                 235                 240 
Pro Arg Gln Val Val His Lys Asn Thr Arg Phe Leu Arg Asp Pro Phe
                245                 250                 255     
Ser Gln Ala Leu Ser Arg Cys Gln Leu Gln Gln Ala Ala Ala Leu Asn
            260                 265                 270         
Ala Gln His Lys Gln Gly Lys Val Gly Pro Asp Gly Lys Glu Leu Ile
        275                 280                 285             
Pro Gln Glu Ser Pro Arg Val Gly Gly Phe Gly Phe Val Ala Thr Pro
    290                 295                 300                 
Ser Pro Ala Pro Gly Val Asn Glu Ser Pro Met Met Thr Trp Gly Glu
305                 310                 315                 320 
Val Glu Asn Thr Pro Leu Arg Val Glu Gly Ser Glu Thr Pro Tyr Val
                325                 330                 335     
Asp Arg Thr Pro Gly Pro Ala Phe Lys Ile Leu Glu Pro Gly Arg Arg
            340                 345                 350         
Glu Arg Leu Gly Leu Lys Met Ala Asn Glu Ala Ala Ala Lys Asn Arg
        355                 360                 365             
Ala Lys Lys Gln Glu Ala Leu Arg Arg Val Thr Glu Asn Leu Ala Ser
    370                 375                 380                 
Leu Thr Pro Lys Gly Leu Ser Pro Ala Met Ser Pro Ala Leu Gln Arg
385                 390                 395                 400 
Leu Val Ser Arg Thr Ala Ser Lys Tyr Thr Asp Arg Ala Leu Arg Ala
                405                 410                 415     
Ser Tyr Thr Pro Ser Pro Ala Arg Ser Thr His Leu Lys Thr Pro Ala
            420                 425                 430         
Ser Gly Leu Gln Thr Pro Thr Ser Thr Pro Ala Pro Gly Ser Ala Thr
        435                 440                 445             
Arg Thr Pro Leu Thr Gln Asp Pro Ala Ser Ile Thr Asp Asn Leu Leu
    450                 455                 460                 
Gln Leu Pro Ala Arg Arg Lys Ala Ser Asp Phe Phe
465                 470                 475     


<210> 8825
<211> 1218
<212> PRT
<213> Homo sapiens

<400> 8825
Met Ser Thr Leu Leu Val Phe Ile Phe Ala Ile Ile Asn Leu Phe Asn
 1               5                  10                  15      
Glu Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu
            20                  25                  30          
Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro
        35                  40                  45              
Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp
    50                  55                  60                  
His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys
65                  70                  75                  80  
Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile
                85                  90                  95      
Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp
            100                 105                 110         
Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu
        115                 120                 125             
Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro
    130                 135                 140                 
Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu
145                 150                 155                 160 
Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn
                165                 170                 175     
His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg
            180                 185                 190         
Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu
        195                 200                 205             
Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr
    210                 215                 220                 
Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln
225                 230                 235                 240 
Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile
                245                 250                 255     
Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn
            260                 265                 270         
Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg
        275                 280                 285             
Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu
    290                 295                 300                 
Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn
305                 310                 315                 320 
His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro
                325                 330                 335     
Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser
            340                 345                 350         
Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln
        355                 360                 365             
Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala Gly Glu Arg His
    370                 375                 380                 
Gly Ser His His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ile
385                 390                 395                 400 
Gly His Gly Gln Ala Ser Thr Ala Val Ser Asp Ser Gly His Arg Gly
                405                 410                 415     
Tyr Arg Gly Ser Gln Ala Ser Asp Asn Glu Gly His Ser Glu Asp Ser
            420                 425                 430         
Asp Ser Gln Ser Val Ala Gly Gln Arg Gln Ala Arg Ser Arg His Gln
        435                 440                 445             
Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Gly Ser Gly Arg
    450                 455                 460                 
Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu Gln Ser Glu Ser
465                 470                 475                 480 
Ser His Gly Trp Ala Arg Thr Ser Thr Gly Arg Arg Gln Gly Ser Arg
                485                 490                 495     
His Asp Gln Ala Gln Asp Ser Ser Arg His Ser Thr Ser Gln Gln Gly
            500                 505                 510         
Gln Asp Thr Ile His Ala His Pro Gly Ser Arg Arg Gly Gly Arg His
        515                 520                 525             
Gly Tyr His His Glu Gln Ser Ala Asp Ser Thr Gly His Ser Gly Ser
    530                 535                 540                 
Gln His Ser His Thr Thr Thr Gln Gly Arg Ser Asp Ala Ser Arg Gly
545                 550                 555                 560 
Ser Ser Gly Ser Arg Ser Thr Ser Arg Glu Thr Arg Asp Gln Glu Gln
                565                 570                 575     
Ser Gly Asp Gly Ser Arg His Ser Gly Ser His His Gln Glu Ala Ser
            580                 585                 590         
Thr Arg Ala Glu Ser Ser Arg His Ser Gln Val Gly Gln Gly Glu Ser
        595                 600                 605             
Ser Gly Ser Arg Thr Ser Arg Asn Gln Gly Ser Ser Phe Ser Gln Asp
    610                 615                 620                 
Arg Asp Ser Gln Ala Gln Ser Glu Asp Ser Glu Arg Arg Ser Ala Ser
625                 630                 635                 640 
Gly Ser Arg Asn His Arg Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly
                645                 650                 655     
Ser Arg His Pro Gly Ser His Gln Glu Asp Arg Ala Gly His Arg Gln
            660                 665                 670         
Ser Ala Glu Ser Ser Ser Gln Ser Gly Thr His His Ala Glu Asn Ser
        675                 680                 685             
Ser Gly Gly Gln Ala Ala Ser Ser Gln Glu Gln Ala Arg Ser Ser Ala
    690                 695                 700                 
Gly Glu Arg His Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg
705                 710                 715                 720 
His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser
                725                 730                 735     
Gly His Arg Gly Tyr Ser Gly Ser Gln Ala Ser Asp Gln Glu Gly His
            740                 745                 750         
Ser Glu Asn Ser Asp Ser Gln Ser Val Ser Gly Gln Arg Gln Ala Arg
        755                 760                 765             
Ser His Gln Gln Ser His Gln Glu Ser Thr Arg Gly Gln Ser Arg Gly
    770                 775                 780                 
Arg Ser Gly Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His Glu
785                 790                 795                 800 
Gln Ser Glu Ser Ala His Gly Arg Ser Ala Pro Ser Thr Arg Arg Arg
                805                 810                 815     
Gln Gly Ser His His Asp Gln Ala Arg Asp Ser Ser Arg His Ser Ala
            820                 825                 830         
Ser Gln Glu Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg
        835                 840                 845             
Gly Gly Arg Gln Gly Ser His Tyr Glu Gln Ser Val Asp Arg Ser Gly
    850                 855                 860                 
His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp
865                 870                 875                 880 
Ala Ser His Gly Thr Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg
                885                 890                 895     
Asp Glu Glu Gln Ser Gly Asp Gly Thr Arg His Ser Gly Ser His His
            900                 905                 910         
Gln Glu Ala Ser Thr Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly
        915                 920                 925             
Gln Gly Gln Ser Ala Gly Ser Arg Thr Ser Arg Asn Gln Gly Ser Ser
    930                 935                 940                 
Val Ser Gln Asp Arg Asp Ser Glu Gly Gln Ser Glu Asp Ser Glu Arg
945                 950                 955                 960 
His Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu Gln
                965                 970                 975     
Ser Arg Asp Gly Ser Arg His Pro Gly Ser His Asp Glu Asp Arg Ala
            980                 985                 990         
Gly His Arg Gln Ser Ala Asp Ser Ser Ser Gln Ser Gly Thr Arg His
        995                 1000                1005            
Thr Gln Thr Ser Ser Arg Arg Gln Ala Ala Ser Ser Gln Glu Gln Ala
    1010                1015                1020                
Arg Ser Arg Ala Gly Asp Arg His Gly Ser Gly His Gln Gln Ser Ala
1025                1030                1035                1040
Asp Ser Ser Arg His Ser Ala Ile Gly Arg Gly Gln Ala Ser Ser Ala
                1045                1050                1055    
Val Arg Asp Arg Gly His Arg Gly Ser Arg Gly Ser Gln Ala Ser Asp
            1060                1065                1070        
Gln Glu Gly His Ser Glu Asp Ser Asp Ser Gln Ser Val Ser Ala Gln
        1075                1080                1085            
Arg Gln Ala Gly Ser His Gln Gln Ser His Gln Glu Ser Thr Arg Gly
    1090                1095                1100                
Arg Ser Gln Gly Arg Ser Gly Arg Ser Gly Ser Phe Ile Tyr Gln Val
1105                1110                1115                1120
Ser Thr His Glu Gln Ser Glu Ser Ala His Gly Arg Thr Arg Thr Ser
                1125                1130                1135    
Thr Gly Arg Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Ser Ser
            1140                1145                1150        
Arg His Ser Ala Ser Gln Glu Gly Gln Asp Thr Ile Arg Ala His Pro
        1155                1160                1165            
Gly Ser Arg Arg Gly Gly Arg Gln Gly Ser His His Glu Gln Ser Val
    1170                1175                1180                
Asp Arg Ser Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln
1185                1190                1195                1200
Gly Arg Ser Asp Ala Ser His Gly Gln Ser Gly Ser Val Asp Leu Gln
                1205                1210                1215    
Val Asp
        


<210> 8826
<211> 655
<212> PRT
<213> Homo sapiens

<400> 8826
Met Ser Ile Leu Ser Ile Leu Ser Leu Lys Leu Leu Ile Lys Ile Phe
 1               5                  10                  15      
Val Val Val Val Val Val Gly Arg Asn Gly Phe Pro Thr Thr Asn Pro
            20                  25                  30          
Ser Gly Pro Pro Leu Gly Glu Gly His Arg Ala Glu Tyr Met Thr Thr
        35                  40                  45              
Arg Pro Pro Asn Val Pro Pro Lys Pro Gln Lys His Arg Lys Ser Arg
    50                  55                  60                  
Pro Arg Ser Gln Tyr Asn Thr Lys Leu Phe Asn Gly Asp Leu Glu Thr
65                  70                  75                  80  
Phe Val Lys Asp Ser Gly Gln Val Ile Pro Leu Ile Val Glu Ser Cys
                85                  90                  95      
Ile Arg Phe Ile Asn Leu Tyr Gly Leu Gln His Gln Gly Ile Phe Arg
            100                 105                 110         
Val Ser Gly Ser Gln Val Glu Val Asn Asp Ile Lys Asn Ser Phe Glu
        115                 120                 125             
Arg Gly Glu Asn Pro Leu Ala Asp Asp Gln Ser Asn His Asp Ile Asn
    130                 135                 140                 
Ser Val Ala Gly Val Leu Lys Leu Tyr Phe Arg Gly Leu Glu Asn Pro
145                 150                 155                 160 
Leu Phe Pro Lys Glu Arg Phe Asn Asp Leu Ile Ser Cys Ile Arg Ile
                165                 170                 175     
Asp Asn Leu Tyr Glu Arg Ala Leu His Ile Arg Lys Leu Leu Leu Thr
            180                 185                 190         
Leu Pro Arg Ser Val Leu Ile Val Met Arg Tyr Leu Phe Ala Phe Leu
        195                 200                 205             
Asn His Leu Ser Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn
    210                 215                 220                 
Leu Ala Ile Cys Phe Gly Pro Thr Leu Met Pro Val Pro Glu Ile Gln
225                 230                 235                 240 
Asp Gln Val Ser Cys Gln Ala His Val Asn Glu Ile Ile Lys Thr Ile
                245                 250                 255     
Ile Ile His His Glu Thr Ile Phe Pro Asp Ala Lys Glu Leu Asp Gly
            260                 265                 270         
Pro Val Tyr Glu Lys Cys Met Ala Gly Asp Asp Tyr Cys Asp Ser Pro
        275                 280                 285             
Tyr Ser Glu His Gly Thr Leu Glu Glu Val Asp Gln Asp Ala Gly Thr
    290                 295                 300                 
Glu Pro His Thr Ser Glu Asp Glu Cys Glu Pro Ile Glu Ala Ile Ala
305                 310                 315                 320 
Lys Phe Asp Tyr Val Gly Arg Ser Ala Arg Glu Leu Ser Phe Lys Lys
                325                 330                 335     
Gly Ala Ser Leu Leu Leu Tyr His Arg Ala Ser Glu Asp Trp Trp Glu
            340                 345                 350         
Gly Arg His Asn Gly Ile Asp Gly Leu Val Pro His Gln Tyr Ile Val
        355                 360                 365             
Val Gln Asp Met Asp Asp Thr Phe Ser Asp Thr Leu Ser Gln Lys Ala
    370                 375                 380                 
Asp Ser Glu Ala Ser Ser Gly Pro Val Thr Glu Asp Lys Ser Ser Ser
385                 390                 395                 400 
Lys Asp Met Asn Ser Pro Thr Asp Arg His Pro Asp Gly Tyr Leu Ala
                405                 410                 415     
Arg Gln Arg Lys Arg Gly Glu Pro Pro Pro Pro Val Arg Arg Pro Gly
            420                 425                 430         
Arg Thr Ser Asp Gly His Cys Pro Leu His Pro Pro His Ala Leu Ser
        435                 440                 445             
Asn Ser Ser Val Asp Leu Gly Ser Pro Ser Leu Ala Ser His Pro Arg
    450                 455                 460                 
Gly Leu Leu Gln Asn Arg Gly Leu Asn Asn Asp Ser Pro Glu Arg Arg
465                 470                 475                 480 
Arg Arg Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His Asp Ser
                485                 490                 495     
Leu Lys Lys Ile Asp Ser Pro Pro Ile Arg Arg Ser Thr Ser Ser Gly
            500                 505                 510         
Gln Tyr Thr Gly Phe Asn Asp His Lys Pro Leu Asp Pro Glu Thr Ile
        515                 520                 525             
Ala Gln Asp Ile Glu Glu Thr Met Asn Thr Ala Leu Asn Glu Leu Arg
    530                 535                 540                 
Glu Leu Glu Arg Gln Ser Thr Ala Lys His Ala Pro Asp Val Val Leu
545                 550                 555                 560 
Asp Thr Leu Glu Gln Val Lys Asn Ser Pro Thr Pro Ala Thr Ser Thr
                565                 570                 575     
Glu Ser Leu Ser Pro Leu His Asn Val Ala Leu Arg Ser Ser Glu Pro
            580                 585                 590         
Gln Ile Arg Arg Ser Thr Ser Ser Ser Ser Asp Thr Met Ser Thr Phe
        595                 600                 605             
Lys Pro Met Val Ala Pro Arg Met Gly Val Gln Leu Lys Pro Pro Ala
    610                 615                 620                 
Leu Arg Pro Lys Pro Ala Val Leu Pro Lys Thr Asn Pro Thr Ile Gly
625                 630                 635                 640 
Pro Ala Pro Pro Pro Gln Gly Pro Thr Asp Lys Ser Cys Thr Met
                645                 650                 655 


<210> 8827
<211> 1085
<212> PRT
<213> Homo sapiens

<400> 8827
Met Ser Thr Pro Ser Arg Phe Lys Lys Asp Lys Glu Ile Ile Ala Glu
 1               5                  10                  15      
Tyr Glu Ser Gln Val Lys Glu Ile Arg Ala Gln Leu Val Glu Gln Gln
            20                  25                  30          
Lys Cys Leu Glu Gln Gln Thr Glu Met Arg Val Gln Leu Leu Gln Asp
        35                  40                  45              
Leu Gln Asp Phe Phe Arg Lys Lys Ala Glu Ile Glu Thr Glu Tyr Ser
    50                  55                  60                  
Arg Asn Leu Glu Lys Leu Ala Glu Arg Phe Met Ala Lys Thr Arg Ser
65                  70                  75                  80  
Thr Lys Asp His Gln Gln Tyr Lys Lys Asp Gln Asn Leu Leu Ser Pro
                85                  90                  95      
Val Asn Cys Trp Tyr Leu Leu Leu Asn Gln Val Arg Arg Glu Ser Lys
            100                 105                 110         
Asp His Ala Thr Leu Ser Asp Ile Tyr Leu Asn Asn Val Ile Met Arg
        115                 120                 125             
Phe Met Gln Ile Ser Glu Asp Ser Thr Arg Met Phe Lys Lys Ser Lys
    130                 135                 140                 
Glu Ile Ala Phe Gln Leu His Glu Asp Leu Met Lys Val Leu Asn Glu
145                 150                 155                 160 
Leu Tyr Thr Val Met Lys Thr Tyr His Met Tyr His Ala Glu Ser Ile
                165                 170                 175     
Ser Ala Glu Ser Lys Leu Lys Glu Ala Glu Lys Gln Glu Glu Lys Gln
            180                 185                 190         
Ile Gly Arg Ser Gly Asp Pro Val Phe His Ile Arg Leu Glu Glu Arg
        195                 200                 205             
His Gln Arg Arg Ser Ser Val Lys Lys Ile Glu Lys Met Lys Glu Lys
    210                 215                 220                 
Arg Gln Ala Lys Tyr Ser Glu Asn Lys Leu Lys Ser Ile Lys Ala Arg
225                 230                 235                 240 
Asn Glu Tyr Leu Leu Thr Leu Glu Ala Thr Asn Ala Ser Val Phe Lys
                245                 250                 255     
Tyr Tyr Ile His Asp Leu Ser Asp Leu Ile Asp Cys Cys Asp Leu Gly
            260                 265                 270         
Tyr His Ala Ser Leu Asn Arg Ala Leu Arg Thr Tyr Leu Ser Ala Glu
        275                 280                 285             
Tyr Asn Leu Glu Thr Ser Arg His Glu Gly Leu Asp Ile Ile Glu Asn
    290                 295                 300                 
Ala Val Asp Asn Leu Glu Pro Arg Ser Asp Lys Gln Arg Phe Met Glu
305                 310                 315                 320 
Met Tyr Pro Ala Ala Phe Cys Pro Pro Met Lys Phe Glu Phe Gln Ser
                325                 330                 335     
His Met Gly Asp Glu Val Cys Gln Val Ser Ala Gln Gln Pro Val Gln
            340                 345                 350         
Ala Glu Leu Met Leu Arg Tyr Gln Gln Leu Gln Ser Arg Leu Ala Thr
        355                 360                 365             
Leu Lys Ile Glu Asn Glu Glu Val Lys Lys Thr Thr Glu Ala Thr Leu
    370                 375                 380                 
Gln Thr Ile Gln Asp Met Val Thr Ile Glu Asp Tyr Asp Val Ser Glu
385                 390                 395                 400 
Cys Phe Gln His Ser Arg Ser Thr Glu Ser Val Lys Ser Thr Val Ser
                405                 410                 415     
Glu Thr Tyr Leu Ser Lys Pro Ser Ile Ala Lys Arg Arg Ala Asn Gln
            420                 425                 430         
Gln Glu Thr Glu Gln Phe Tyr Phe Met Lys Leu Arg Glu Tyr Leu Glu
        435                 440                 445             
Gly Ser Asn Leu Ile Thr Lys Leu Gln Ala Lys His Asp Leu Leu Gln
    450                 455                 460                 
Arg Thr Leu Gly Glu Gly His Arg Ala Glu Tyr Met Thr Thr Arg Pro
465                 470                 475                 480 
Pro Asn Val Pro Pro Lys Pro Gln Lys His Arg Lys Ser Arg Pro Arg
                485                 490                 495     
Ser Gln Tyr Asn Thr Lys Leu Phe Asn Gly Asp Leu Glu Thr Phe Val
            500                 505                 510         
Lys Asp Ser Gly Gln Val Ile Pro Leu Ile Val Glu Ser Cys Ile Arg
        515                 520                 525             
Phe Ile Asn Leu Tyr Gly Leu Gln His Gln Gly Ile Phe Arg Val Ser
    530                 535                 540                 
Gly Ser Gln Val Glu Val Asn Asp Ile Lys Asn Ser Phe Glu Arg Gly
545                 550                 555                 560 
Glu Asn Pro Leu Ala Asp Asp Gln Ser Asn His Asp Ile Asn Ser Val
                565                 570                 575     
Ala Gly Val Leu Lys Leu Tyr Phe Arg Gly Leu Glu Asn Pro Leu Phe
            580                 585                 590         
Pro Lys Glu Arg Phe Asn Asp Leu Ile Ser Cys Ile Arg Ile Asp Asn
        595                 600                 605             
Leu Tyr Glu Arg Ala Leu His Ile Arg Lys Leu Leu Leu Thr Leu Pro
    610                 615                 620                 
Arg Ser Val Leu Ile Val Met Arg Tyr Leu Phe Ala Phe Leu Asn His
625                 630                 635                 640 
Leu Ser Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu Ala
                645                 650                 655     
Ile Cys Phe Gly Pro Thr Leu Met Pro Val Pro Glu Ile Gln Asp Gln
            660                 665                 670         
Val Ser Cys Gln Ala His Val Asn Glu Ile Ile Lys Thr Ile Ile Ile
        675                 680                 685             
His His Glu Thr Ile Phe Pro Asp Ala Lys Glu Leu Asp Gly Pro Val
    690                 695                 700                 
Tyr Glu Lys Cys Met Ala Gly Asp Asp Tyr Cys Asp Ser Pro Tyr Ser
705                 710                 715                 720 
Glu His Gly Thr Leu Glu Glu Val Asp Gln Asp Ala Gly Thr Glu Pro
                725                 730                 735     
His Thr Ser Glu Asp Glu Cys Glu Pro Ile Glu Ala Ile Ala Lys Phe
            740                 745                 750         
Asp Tyr Val Gly Arg Ser Ala Arg Glu Leu Ser Phe Lys Lys Gly Ala
        755                 760                 765             
Ser Leu Leu Leu Tyr His Arg Ala Ser Glu Asp Trp Trp Glu Gly Arg
    770                 775                 780                 
His Asn Gly Ile Asp Gly Leu Val Pro His Gln Tyr Ile Val Val Gln
785                 790                 795                 800 
Asp Met Asp Asp Thr Phe Ser Asp Thr Leu Ser Gln Lys Ala Asp Ser
                805                 810                 815     
Glu Ala Ser Ser Gly Pro Val Thr Glu Asp Lys Ser Ser Ser Lys Asp
            820                 825                 830         
Met Asn Ser Pro Thr Asp Arg His Pro Asp Gly Tyr Leu Ala Arg Gln
        835                 840                 845             
Arg Lys Arg Gly Glu Pro Pro Pro Pro Val Arg Arg Pro Gly Arg Thr
    850                 855                 860                 
Ser Asp Gly His Cys Pro Leu His Pro Pro His Ala Leu Ser Asn Ser
865                 870                 875                 880 
Ser Val Asp Leu Gly Ser Pro Ser Leu Ala Ser His Pro Arg Gly Leu
                885                 890                 895     
Leu Gln Asn Arg Gly Leu Asn Asn Asp Ser Pro Glu Arg Arg Arg Arg
            900                 905                 910         
Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His Asp Ser Leu Lys
        915                 920                 925             
Lys Ile Asp Ser Pro Pro Ile Arg Arg Ser Thr Ser Ser Gly Gln Tyr
    930                 935                 940                 
Thr Gly Phe Asn Asp His Lys Pro Leu Asp Pro Glu Thr Ile Ala Gln
945                 950                 955                 960 
Asp Ile Glu Glu Thr Met Asn Thr Ala Leu Asn Glu Leu Arg Glu Leu
                965                 970                 975     
Glu Arg Gln Ser Thr Ala Lys His Ala Pro Asp Val Val Leu Asp Thr
            980                 985                 990         
Leu Glu Gln Val Lys Asn Ser Pro Thr Pro Ala Thr Ser Thr Glu Ser
        995                 1000                1005            
Leu Ser Pro Leu His Asn Val Ala Leu Arg Ser Ser Glu Pro Gln Ile
    1010                1015                1020                
Arg Arg Ser Thr Ser Ser Ser Ser Asp Thr Met Ser Thr Phe Lys Pro
1025                1030                1035                1040
Met Val Ala Pro Arg Met Gly Val Gln Leu Lys Pro Pro Ala Leu Arg
                1045                1050                1055    
Pro Lys Pro Ala Val Leu Pro Lys Thr Asn Pro Thr Ile Gly Pro Ala
            1060                1065                1070        
Pro Pro Pro Gln Gly Pro Thr Asp Lys Ser Cys Thr Met
        1075                1080                1085


<210> 8828
<211> 1324
<212> PRT
<213> Homo sapiens

<400> 8828
Gln Ala Glu Pro Ser Gly Ala Gly Thr Glu Leu Tyr Leu Phe Ala Val
 1               5                  10                  15      
Leu Phe Asp Leu Leu Val Ser Glu Ser Ser Leu Asp His Leu Met Ala
            20                  25                  30          
Met Gly Asp Asp Lys Ser Phe Asp Asp Glu Glu Ser Val Asp Gly Asn
        35                  40                  45              
Arg Pro Ser Ser Ala Ala Ser Ala Phe Lys Val Pro Ala Pro Lys Thr
    50                  55                  60                  
Ser Gly Asn Pro Ala Asn Ser Ala Arg Lys Pro Gly Ser Ala Gly Gly
65                  70                  75                  80  
Pro Lys Val Gly Gly Ala Ser Lys Glu Gly Gly Ala Gly Ala Val Asp
                85                  90                  95      
Glu Asp Asp Phe Ile Lys Ala Phe Thr Asp Val Pro Ser Ile Gln Ile
            100                 105                 110         
Tyr Ser Ser Arg Glu Leu Glu Glu Thr Leu Asn Lys Ile Arg Glu Ile
        115                 120                 125             
Leu Ser Asp Asp Lys His Asp Trp Asp Gln Arg Ala Asn Ala Leu Lys
    130                 135                 140                 
Lys Ile Arg Ser Leu Leu Val Ala Gly Ala Ala Gln Tyr Asp Cys Phe
145                 150                 155                 160 
Phe Gln His Leu Arg Leu Leu Asp Gly Ala Leu Lys Leu Ser Ala Lys
                165                 170                 175     
Asp Leu Arg Ser Gln Val Val Arg Glu Ala Cys Ile Thr Val Ala His
            180                 185                 190         
Leu Ser Thr Val Leu Gly Asn Lys Phe Asp His Gly Ala Glu Ala Ile
        195                 200                 205             
Val Pro Thr Leu Phe Asn Leu Val Pro Asn Ser Ala Lys Val Met Ala
    210                 215                 220                 
Thr Ser Gly Cys Ala Ala Ile Arg Phe Ile Ile Arg His Thr His Val
225                 230                 235                 240 
Pro Arg Leu Ile Pro Leu Ile Thr Ser Asn Cys Thr Ser Lys Ser Val
                245                 250                 255     
Pro Val Arg Arg Arg Ser Phe Glu Phe Leu Asp Leu Leu Leu Gln Glu
            260                 265                 270         
Trp Gln Thr His Ser Leu Glu Arg His Ala Ala Val Leu Val Glu Thr
        275                 280                 285             
Ile Lys Lys Gly Ile His Asp Ala Asp Ala Glu Ala Arg Val Glu Ala
    290                 295                 300                 
Arg Lys Thr Tyr Met Gly Leu Arg Asn His Phe Pro Gly Glu Ala Glu
305                 310                 315                 320 
Thr Leu Tyr Asn Ser Leu Glu Pro Ser Tyr Gln Lys Ser Leu Gln Thr
                325                 330                 335     
Tyr Leu Lys Ser Ser Gly Ser Val Ala Ser Leu Pro Gln Ser Asp Arg
            340                 345                 350         
Ser Ser Ser Ser Ser Gln Glu Ser Leu Asn Arg Pro Phe Ser Ser Lys
        355                 360                 365             
Trp Ser Thr Ala Asn Pro Ser Thr Val Ala Gly Arg Val Ser Ala Gly
    370                 375                 380                 
Ser Ser Lys Ala Ser Ser Leu Pro Gly Ser Leu Gln Arg Ser Arg Ser
385                 390                 395                 400 
Asp Ile Asp Val Asn Ala Ala Ala Gly Ala Lys Ala His His Ala Ala
                405                 410                 415     
Gly Gln Ser Val Arg Arg Gly Arg Leu Gly Ala Gly Ala Leu Asn Ala
            420                 425                 430         
Gly Ser Tyr Ala Ser Leu Glu Asp Thr Ser Asp Lys Leu Asp Gly Thr
        435                 440                 445             
Ala Ser Glu Asp Gly Arg Val Arg Ala Lys Leu Ser Ala Pro Leu Ala
    450                 455                 460                 
Gly Met Gly Asn Ala Lys Ala Asp Ser Arg Gly Arg Ser Arg Thr Lys
465                 470                 475                 480 
Met Val Ser Gln Ser Gln Pro Gly Ser Arg Ser Gly Ser Pro Gly Arg
                485                 490                 495     
Val Leu Thr Thr Thr Ala Leu Ser Thr Val Ser Ser Gly Val Gln Arg
            500                 505                 510         
Val Leu Val Asn Ser Ala Ser Ala Gln Lys Arg Ser Lys Ile Pro Arg
        515                 520                 525             
Ser Gln Gly Cys Ser Arg Glu Ala Ser Pro Ser Arg Leu Ser Val Ala
    530                 535                 540                 
Arg Ser Ser Arg Ile Pro Arg Pro Ser Val Ser Gln Gly Cys Ser Arg
545                 550                 555                 560 
Glu Ala Ser Arg Glu Ser Ser Arg Asp Thr Ser Pro Val Arg Ser Phe
                565                 570                 575     
Gln Pro Leu Ala Ser Arg His His Ser Arg Ser Thr Gly Ala Leu Tyr
            580                 585                 590         
Ala Pro Glu Val Tyr Gly Ala Ser Gly Pro Gly Tyr Gly Ile Ser Gln
        595                 600                 605             
Ser Ser Arg Leu Ser Ser Ser Val Ser Ala Met Arg Val Leu Asn Thr
    610                 615                 620                 
Gly Ser Asp Val Glu Glu Ala Val Ala Asp Ala Leu Lys Lys Pro Ala
625                 630                 635                 640 
Arg Arg Arg Tyr Glu Ser Tyr Gly Met His Ser Asp Asp Asp Ala Asn
                645                 650                 655     
Ser Asp Ala Ser Ser Ala Cys Ser Glu Arg Ser Tyr Ser Ser Arg Asn
            660                 665                 670         
Gly Ser Ile Pro Thr Tyr Met Arg Gln Thr Glu Asp Val Ala Glu Val
        675                 680                 685             
Leu Asn Arg Cys Ala Ser Ser Asn Trp Ser Glu Arg Lys Glu Gly Leu
    690                 695                 700                 
Leu Gly Leu Gln Asn Leu Leu Lys Asn Gln Arg Thr Leu Ser Arg Val
705                 710                 715                 720 
Glu Leu Lys Arg Leu Cys Glu Ile Phe Thr Arg Met Phe Ala Asp Pro
                725                 730                 735     
His Gly Lys Arg Val Phe Ser Met Phe Leu Glu Thr Leu Val Asp Phe
            740                 745                 750         
Ile Gln Val His Lys Asp Asp Leu Gln Asp Trp Leu Phe Val Leu Leu
        755                 760                 765             
Thr Gln Leu Leu Lys Lys Met Gly Ala Asp Leu Leu Gly Ser Val Gln
    770                 775                 780                 
Ala Lys Val Gln Lys Ala Leu Asp Val Thr Arg Glu Ser Phe Pro Asn
785                 790                 795                 800 
Asp Leu Gln Phe Asn Ile Leu Met Arg Phe Thr Val Asp Gln Thr Gln
                805                 810                 815     
Thr Pro Ser Leu Lys Val Lys Val Ala Ile Leu Lys Tyr Ile Glu Thr
            820                 825                 830         
Leu Ala Lys Gln Met Asp Pro Gly Asp Phe Ile Asn Ser Ser Glu Thr
        835                 840                 845             
Arg Leu Ala Val Ser Arg Val Ile Thr Trp Thr Thr Glu Pro Lys Ser
    850                 855                 860                 
Ser Asp Val Arg Lys Ala Ala Gln Ser Val Leu Ile Ser Leu Phe Glu
865                 870                 875                 880 
Leu Asn Thr Pro Glu Phe Thr Met Leu Leu Gly Ala Leu Pro Lys Thr
                885                 890                 895     
Phe Gln Asp Gly Ala Thr Lys Leu Leu His Asn His Leu Arg Asn Thr
            900                 905                 910         
Gly Asn Gly Thr Gln Ser Ser Met Gly Ser Pro Leu Thr Arg Pro Thr
        915                 920                 925             
Pro Arg Ser Pro Ala Asn Trp Ser Ser Pro Leu Thr Ser Pro Thr Asn
    930                 935                 940                 
Thr Ser Gln Asn Thr Leu Ser Pro Ser Ala Phe Asp Tyr Asp Thr Glu
945                 950                 955                 960 
Asn Met Asn Ser Glu Asp Ile Tyr Ser Ser Leu Arg Gly Val Thr Glu
                965                 970                 975     
Ala Ile Gln Asn Phe Ser Phe Arg Ser Gln Glu Asp Met Asn Glu Pro
            980                 985                 990         
Leu Lys Arg Asp Ser Lys Lys Asp Asp Gly Asp Ser Met Cys Gly Gly
        995                 1000                1005            
Pro Gly Met Ser Asp Pro Arg Ala Gly Gly Asp Ala Thr Asp Ser Ser
    1010                1015                1020                
Gln Thr Ala Leu Asp Asn Lys Ala Ser Leu Leu His Ser Met Pro Thr
1025                1030                1035                1040
His Ser Ser Pro Arg Ser Arg Asp Tyr Asn Pro Tyr Asn Tyr Ser Asp
                1045                1050                1055    
Ser Ile Ser Pro Phe Asn Lys Ser Ala Leu Lys Glu Ala Met Phe Asp
            1060                1065                1070        
Asp Asp Ala Asp Gln Phe Pro Asp Asp Leu Ser Leu Asp His Ser Asp
        1075                1080                1085            
Leu Val Ala Glu Leu Leu Lys Glu Leu Ser Asn His Asn Glu Arg Val
    1090                1095                1100                
Glu Glu Arg Lys Ile Ala Leu Tyr Glu Leu Met Lys Leu Thr Gln Glu
1105                1110                1115                1120
Glu Ser Phe Ser Val Trp Asp Glu His Phe Lys Thr Ile Leu Leu Leu
                1125                1130                1135    
Leu Leu Glu Thr Leu Gly Asp Lys Glu Pro Thr Ile Arg Ala Leu Ala
            1140                1145                1150        
Leu Lys Val Leu Arg Glu Ile Leu Arg His Gln Pro Ala Arg Phe Lys
        1155                1160                1165            
Asn Tyr Ala Glu Leu Thr Val Met Lys Thr Leu Glu Ala His Lys Asp
    1170                1175                1180                
Pro His Lys Glu Val Val Arg Ser Ala Glu Glu Ala Ala Ser Val Leu
1185                1190                1195                1200
Ala Thr Ser Ile Ser Pro Glu Gln Cys Ile Lys Val Leu Cys Pro Ile
                1205                1210                1215    
Ile Gln Thr Ala Asp Tyr Pro Ile Asn Leu Ala Ala Ile Lys Met Gln
            1220                1225                1230        
Thr Lys Val Ile Glu Arg Val Ser Lys Glu Thr Leu Asn Leu Leu Leu
        1235                1240                1245            
Pro Glu Ile Met Pro Gly Leu Ile Gln Gly Tyr Asp Asn Ser Glu Ser
    1250                1255                1260                
Ser Val Arg Lys Ala Cys Val Phe Cys Leu Val Ala Val His Ala Val
1265                1270                1275                1280
Ile Gly Asp Glu Leu Lys Pro His Leu Ser Gln Leu Thr Gly Ser Lys
                1285                1290                1295    
Met Lys Leu Leu Asn Leu Tyr Ile Lys Arg Ala Gln Thr Gly Ser Gly
            1300                1305                1310        
Gly Ala Asp Pro Thr Thr Asp Val Ser Gly Gln Ser
        1315                1320                


<210> 8829
<211> 770
<212> PRT
<213> Homo sapiens

<400> 8829
Met Val Glu Ser Ala Gly Arg Ala Gly Gln Lys Arg Pro Gly Phe Leu
 1               5                  10                  15      
Glu Gly Gly Leu Leu Leu Leu Leu Leu Leu Val Thr Ala Ala Leu Val
            20                  25                  30          
Ala Leu Gly Val Leu Tyr Ala Asp Arg Arg Gly Lys Gln Leu Pro Arg
        35                  40                  45              
Leu Ala Ser Arg Leu Cys Phe Leu Gln Glu Glu Arg Thr Phe Val Lys
    50                  55                  60                  
Arg Lys Pro Arg Gly Ile Pro Glu Ala Gln Glu Val Ser Glu Val Cys
65                  70                  75                  80  
Thr Thr Pro Gly Cys Val Ile Ala Ala Ala Arg Ile Leu Gln Asn Met
                85                  90                  95      
Asp Pro Thr Thr Glu Pro Cys Asp Asp Phe Tyr Gln Phe Ala Cys Gly
            100                 105                 110         
Gly Trp Leu Arg Arg His Val Ile Pro Glu Thr Asn Ser Arg Tyr Ser
        115                 120                 125             
Ile Phe Asp Val Leu Arg Asp Glu Leu Glu Val Ile Leu Lys Ala Val
    130                 135                 140                 
Leu Glu Asn Ser Thr Ala Lys Asp Arg Pro Ala Val Glu Lys Ala Arg
145                 150                 155                 160 
Thr Leu Tyr Arg Ser Cys Met Asn Gln Ser Val Ile Glu Lys Arg Gly
                165                 170                 175     
Ser Gln Pro Leu Leu Asp Ile Leu Glu Val Val Gly Gly Trp Pro Val
            180                 185                 190         
Ala Met Asp Arg Trp Asn Glu Thr Val Gly Leu Glu Trp Glu Leu Glu
        195                 200                 205             
Arg Gln Leu Ala Leu Met Asn Ser Gln Phe Asn Arg Arg Val Leu Ile
    210                 215                 220                 
Asp Leu Phe Ile Trp Asn Asp Asp Gln Asn Ser Ser Arg His Ile Ile
225                 230                 235                 240 
Tyr Ile Asp Gln Pro Thr Leu Gly Met Pro Ser Arg Glu Tyr Tyr Phe
                245                 250                 255     
Asn Gly Gly Ser Asn Arg Lys Val Arg Glu Ala Tyr Leu Gln Phe Met
            260                 265                 270         
Val Ser Val Ala Thr Leu Leu Arg Glu Asp Ala Asn Leu Pro Arg Asp
        275                 280                 285             
Ser Cys Leu Val Gln Glu Asp Met Val Gln Val Leu Glu Leu Glu Thr
    290                 295                 300                 
Gln Leu Ala Lys Ala Thr Val Pro Gln Glu Glu Arg His Asp Val Ile
305                 310                 315                 320 
Ala Leu Tyr His Arg Met Gly Leu Glu Glu Leu Gln Ser Gln Phe Gly
                325                 330                 335     
Leu Lys Gly Phe Asn Trp Thr Leu Phe Ile Gln Thr Val Leu Ser Ser
            340                 345                 350         
Val Lys Ile Lys Leu Leu Pro Asp Glu Glu Val Val Val Tyr Gly Ile
        355                 360                 365             
Pro Tyr Leu Gln Asn Leu Glu Asn Ile Ile Asp Thr Tyr Ser Ala Arg
    370                 375                 380                 
Thr Ile Gln Asn Tyr Leu Val Trp Arg Leu Val Leu Asp Arg Ile Gly
385                 390                 395                 400 
Ser Leu Ser Gln Arg Phe Lys Asp Thr Arg Val Asn Tyr Arg Lys Ala
                405                 410                 415     
Leu Phe Gly Thr Met Val Glu Glu Val Arg Trp Arg Glu Cys Val Gly
            420                 425                 430         
Tyr Val Asn Ser Asn Met Glu Asn Ala Val Gly Ser Leu Tyr Val Arg
        435                 440                 445             
Glu Ala Phe Pro Gly Asp Ser Lys Ser Met Val Arg Glu Leu Ile Asp
    450                 455                 460                 
Lys Val Arg Thr Val Phe Val Glu Thr Leu Asp Glu Leu Gly Trp Met
465                 470                 475                 480 
Asp Glu Glu Ser Lys Lys Lys Ala Gln Glu Lys Ala Met Ser Ile Arg
                485                 490                 495     
Glu Gln Ile Gly His Pro Asp Tyr Ile Leu Glu Glu Met Asn Arg Arg
            500                 505                 510         
Leu Asp Glu Glu Tyr Ser Asn Leu Asn Phe Ser Glu Asp Leu Tyr Phe
        515                 520                 525             
Glu Asn Ser Leu Gln Asn Leu Lys Val Gly Ala Gln Arg Ser Leu Arg
    530                 535                 540                 
Lys Leu Arg Glu Lys Val Asp Pro Asn Leu Trp Ile Ile Gly Ala Ala
545                 550                 555                 560 
Val Val Asn Ala Phe Tyr Ser Pro Asn Arg Asn Gln Ile Val Phe Pro
                565                 570                 575     
Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser Lys Glu Gln Pro Gln Ala
            580                 585                 590         
Leu Asn Phe Gly Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His
        595                 600                 605             
Gly Phe Asp Asp Asn Gly Arg Asn Phe Asp Lys Asn Gly Asn Met Met
    610                 615                 620                 
Asp Trp Trp Ser Asn Phe Ser Thr Gln His Phe Arg Glu Gln Ser Glu
625                 630                 635                 640 
Cys Met Ile Tyr Gln Tyr Gly Asn Tyr Ser Trp Asp Leu Ala Asp Glu
                645                 650                 655     
Gln Asn Val Asn Gly Phe Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn
            660                 665                 670         
Gly Gly Val Arg Gln Ala Tyr Lys Ala Tyr Leu Lys Trp Met Ala Glu
        675                 680                 685             
Gly Gly Lys Asp Gln Gln Leu Pro Gly Leu Asp Leu Thr His Glu Gln
    690                 695                 700                 
Leu Phe Phe Ile Asn Tyr Ala Gln Val Trp Cys Gly Ser Tyr Arg Pro
705                 710                 715                 720 
Glu Phe Ala Ile Gln Ser Ile Lys Thr Asp Val His Ser Pro Leu Lys
                725                 730                 735     
Tyr Arg Val Leu Gly Ser Leu Gln Asn Leu Ala Ala Phe Ala Asp Thr
            740                 745                 750         
Phe His Cys Ala Arg Gly Thr Pro Met His Pro Lys Glu Arg Cys Arg
        755                 760                 765             
Val Trp
    770 


<210> 8830
<211> 432
<212> PRT
<213> Homo sapiens

<400> 8830
Met Ala Gly Leu Gly Leu Gly Ser Ala Val Pro Val Trp Leu Ala Glu
 1               5                  10                  15      
Asp Asp Leu Gly Cys Ile Ile Cys Gln Gly Leu Leu Asp Trp Pro Ala
            20                  25                  30          
Thr Leu Pro Cys Gly His Ser Phe Cys Arg His Cys Leu Glu Ala Leu
        35                  40                  45              
Trp Gly Ala Arg Asp Ala Arg Arg Trp Ala Cys Pro Thr Cys Arg Gln
    50                  55                  60                  
Gly Ala Ala Gln Gln Pro His Leu Arg Lys Asn Thr Leu Leu Gln Asp
65                  70                  75                  80  
Leu Ala Asp Lys Tyr Arg Arg Ala Ala Arg Glu Ile Gln Ala Gly Ser
                85                  90                  95      
Asp Pro Ala His Cys Pro Cys Pro Gly Ser Ser Ser Leu Ser Ser Ala
            100                 105                 110         
Ala Ala Arg Pro Arg Arg Arg Pro Glu Leu Gln Arg Val Ala Val Glu
        115                 120                 125             
Lys Ser Ile Thr Glu Val Ala Gln Glu Leu Thr Glu Leu Val Glu His
    130                 135                 140                 
Leu Val Asp Ile Val Arg Ser Leu Gln Asn Gln Arg Pro Leu Ser Glu
145                 150                 155                 160 
Ser Gly Pro Asp Asn Glu Leu Ser Ile Leu Gly Lys Ala Phe Ser Ser
                165                 170                 175     
Gly Val Asp Leu Ser Met Ala Ser Pro Lys Leu Val Thr Ser Asp Thr
            180                 185                 190         
Ala Ala Gly Lys Ile Arg Asp Ile Leu His Asp Leu Glu Glu Ile Gln
        195                 200                 205             
Glu Lys Leu Gln Glu Ser Val Thr Trp Lys Glu Ala Pro Glu Ala Gln
    210                 215                 220                 
Met Gln Gly Glu Leu Leu Glu Ala Pro Ser Ser Ser Ser Cys Pro Leu
225                 230                 235                 240 
Pro Asp Gln Ser His Pro Ala Leu Arg Arg Ala Ser Arg Phe Ala Gln
                245                 250                 255     
Trp Ala Ile His Pro Thr Phe Asn Leu Lys Ser Leu Ser Cys Ser Leu
            260                 265                 270         
Glu Gly Ser Lys Asp Ser Arg Thr Val Thr Val Ser His Arg Pro Gln
        275                 280                 285             
Pro Tyr Arg Trp Asn Cys Glu Arg Phe Ser Thr Ser Gln Val Leu Cys
    290                 295                 300                 
Ser Gln Ala Leu Ser Ser Gly Lys His Tyr Trp Glu Val Asp Thr Arg
305                 310                 315                 320 
Asn Cys Ser His Trp Ala Val Gly Val Ala Ser Trp Glu Met Ser Arg
                325                 330                 335     
Asp Gln Val Leu Gly Arg Thr Met Asp Ser Cys Cys Val Glu Trp Lys
            340                 345                 350         
Gly Thr Ser Gln Leu Ser Ala Trp His Met Val Lys Glu Thr Val Leu
        355                 360                 365             
Gly Ser Asp Arg Pro Gly Val Val Gly Ile Trp Leu Asn Leu Glu Glu
    370                 375                 380                 
Gly Lys Leu Ala Phe Tyr Ser Val Asp Asn Gln Glu Lys Leu Leu Tyr
385                 390                 395                 400 
Glu Cys Thr Ile Ser Ala Ser Ser Pro Leu Tyr Pro Ala Phe Trp Leu
                405                 410                 415     
Tyr Gly Leu His Pro Gly Asn Tyr Leu Ile Ile Lys Gln Val Lys Val
            420                 425                 430         


<210> 8831
<211> 509
<212> PRT
<213> Homo sapiens

<400> 8831
Met Ala Ala Ile Gly Val His Leu Gly Cys Thr Ser Ala Cys Val Ala
 1               5                  10                  15      
Val Tyr Lys Asp Gly Arg Ala Gly Val Val Ala Asn Asp Ala Gly Asp
            20                  25                  30          
Arg Val Thr Pro Ala Val Val Ala Tyr Ser Glu Asn Glu Glu Ile Val
        35                  40                  45              
Gly Leu Ala Ala Lys Gln Ser Arg Ile Arg Asn Ile Ser Asn Thr Val
    50                  55                  60                  
Met Lys Val Lys Gln Ile Leu Gly Arg Ser Ser Ser Asp Pro Gln Ala
65                  70                  75                  80  
Gln Lys Tyr Ile Ala Glu Ser Lys Cys Leu Val Ile Glu Lys Asn Gly
                85                  90                  95      
Lys Leu Arg Tyr Glu Ile Asp Thr Gly Glu Glu Thr Lys Phe Val Asn
            100                 105                 110         
Pro Glu Asp Val Ala Arg Leu Ile Phe Ser Lys Met Lys Glu Thr Ala
        115                 120                 125             
His Ser Val Leu Gly Ser Asp Ala Asn Asp Val Val Ile Thr Val Pro
    130                 135                 140                 
Phe Asp Phe Gly Glu Lys Gln Lys Asn Ala Leu Gly Glu Ala Ala Arg
145                 150                 155                 160 
Ala Ala Gly Phe Asn Val Leu Arg Leu Ile His Glu Pro Ser Ala Ala
                165                 170                 175     
Leu Leu Ala Tyr Gly Ile Gly Gln Asp Ser Pro Thr Gly Lys Ser Asn
            180                 185                 190         
Ile Leu Val Phe Lys Leu Gly Gly Thr Ser Leu Ser Leu Ser Val Met
        195                 200                 205             
Glu Val Asn Ser Gly Ile Tyr Arg Val Leu Ser Thr Asn Thr Asp Asp
    210                 215                 220                 
Asn Ile Gly Gly Ala His Phe Thr Glu Thr Leu Ala Gln Tyr Leu Ala
225                 230                 235                 240 
Ser Glu Phe Gln Arg Ser Phe Lys His Asp Val Arg Gly Asn Ala Arg
                245                 250                 255     
Ala Met Met Lys Leu Thr Asn Ser Ala Glu Val Ala Lys His Ser Leu
            260                 265                 270         
Ser Thr Leu Gly Ser Ala Asn Cys Phe Pro Asp Ser Leu Tyr Glu Gly
        275                 280                 285             
Gln Asp Phe Asp Cys Asn Val Ser Arg Ala Arg Phe Glu Leu Leu Cys
    290                 295                 300                 
Ser Pro Leu Phe Asn Lys Cys Leu Glu Ala Ile Arg Gly Leu Leu Asp
305                 310                 315                 320 
Gln Asn Gly Phe Thr Ala Asp Asp Ile Asn Lys Val Val Leu Cys Gly
                325                 330                 335     
Gly Ser Ser Arg Ile Pro Lys Leu Gln Gln Leu Ile Lys Asp Leu Phe
            340                 345                 350         
Pro Ala Val Glu Leu Leu Asn Ser Ile Pro Pro Asp Glu Val Ile Pro
        355                 360                 365             
Ile Gly Ala Ala Ile Glu Ala Gly Ile Leu Ile Gly Lys Glu Asn Leu
    370                 375                 380                 
Leu Val Glu Asp Ser Leu Met Ile Glu Cys Ser Ala Arg Asp Ile Leu
385                 390                 395                 400 
Val Lys Gly Val Asp Glu Ser Gly Ala Ser Arg Phe Thr Val Leu Phe
                405                 410                 415     
Pro Ser Gly Thr Pro Leu Pro Ala Arg Arg Gln His Thr Leu Gln Ala
            420                 425                 430         
Pro Gly Ser Ile Ser Ser Val Cys Leu Glu Leu Tyr Glu Ser Asp Gly
        435                 440                 445             
Lys Asn Ser Ala Lys Glu Glu Thr Lys Phe Ala Gln Val Val Leu Gln
    450                 455                 460                 
Asp Leu Asp Lys Lys Glu Asn Gly Leu Arg Asp Ile Leu Ala Val Leu
465                 470                 475                 480 
Thr Met Lys Arg Asp Gly Ser Leu His Val Thr Cys Thr Asp Gln Glu
                485                 490                 495     
Thr Gly Lys Cys Glu Ala Ile Ser Ile Glu Ile Ala Ser
            500                 505                 


<210> 8832
<211> 509
<212> PRT
<213> Homo sapiens

<400> 8832
Met Ala Ala Ile Gly Val His Leu Gly Cys Thr Ser Ala Cys Glu Ala
 1               5                  10                  15      
Val Tyr Lys Asp Gly Arg Ala Gly Val Val Ala Asn Asp Ala Gly Asp
            20                  25                  30          
Arg Val Thr Pro Ala Val Val Ala Tyr Ser Glu Asn Glu Glu Ile Val
        35                  40                  45              
Gly Leu Ala Ala Lys Gln Ser Arg Ile Arg Asn Ile Ser Asn Thr Val
    50                  55                  60                  
Met Lys Val Lys Gln Ile Leu Gly Arg Ser Ser Ser Asp Pro Gln Ala
65                  70                  75                  80  
Gln Lys Tyr Ile Ala Glu Ser Lys Cys Leu Val Ile Glu Lys Asn Gly
                85                  90                  95      
Lys Leu Arg Tyr Glu Ile Asp Thr Gly Glu Glu Thr Lys Phe Val Asn
            100                 105                 110         
Pro Glu Asp Val Ala Arg Leu Ile Phe Ser Lys Met Lys Glu Thr Ala
        115                 120                 125             
His Ser Val Leu Gly Ser Asp Ala Asn Asp Val Val Ile Thr Val Pro
    130                 135                 140                 
Phe Asp Phe Gly Glu Lys Gln Lys Asn Ala Leu Gly Glu Ala Ala Arg
145                 150                 155                 160 
Ala Ala Gly Phe Asn Val Leu Arg Leu Ile His Glu Pro Ser Ala Ala
                165                 170                 175     
Leu Leu Ala Tyr Gly Ile Gly Gln Asp Ser Pro Thr Gly Lys Ser Asn
            180                 185                 190         
Ile Leu Val Phe Lys Leu Gly Gly Thr Ser Leu Ser Leu Ser Val Met
        195                 200                 205             
Glu Val Asn Ser Gly Ile Tyr Arg Val Leu Ser Thr Asn Thr Asp Asp
    210                 215                 220                 
Asn Ile Gly Gly Ala His Phe Thr Glu Thr Leu Ala Gln Tyr Leu Ala
225                 230                 235                 240 
Ser Glu Phe Gln Arg Ser Phe Lys His Asp Val Arg Gly Asn Ala Arg
                245                 250                 255     
Ala Met Met Lys Leu Thr Asn Ser Ala Glu Val Ala Lys His Ser Leu
            260                 265                 270         
Ser Thr Leu Gly Ser Ala Asn Cys Phe Leu Asp Ser Leu Tyr Glu Gly
        275                 280                 285             
Gln Asp Phe Asp Cys Asn Val Ser Arg Ala Arg Phe Glu Leu Leu Cys
    290                 295                 300                 
Ser Pro Leu Phe Asn Lys Cys Ile Glu Ala Ile Arg Gly Leu Leu Asp
305                 310                 315                 320 
Gln Asn Gly Phe Thr Ala Asp Asp Ile Asn Lys Val Val Leu Cys Gly
                325                 330                 335     
Gly Ser Ser Arg Ile Pro Lys Leu Gln Gln Leu Ile Lys Asp Leu Phe
            340                 345                 350         
Pro Ala Val Glu Leu Leu Asn Ser Ile Pro Pro Asp Glu Val Ile Pro
        355                 360                 365             
Ile Gly Ala Ala Ile Glu Ala Gly Ile Leu Ile Gly Lys Glu Asn Leu
    370                 375                 380                 
Leu Val Glu Asp Ser Leu Met Ile Glu Cys Ser Ala Arg Asp Ile Leu
385                 390                 395                 400 
Val Lys Gly Val Asp Glu Ser Gly Ala Ser Arg Phe Thr Val Leu Phe
                405                 410                 415     
Pro Ser Gly Thr Pro Leu Pro Ala Arg Arg Gln His Thr Leu Gln Ala
            420                 425                 430         
Pro Gly Ser Ile Ser Ser Val Cys Leu Glu Leu Tyr Glu Ser Asp Gly
        435                 440                 445             
Lys Asn Ser Ala Lys Glu Glu Thr Lys Phe Ala Gln Val Val Leu Gln
    450                 455                 460                 
Asp Leu Asp Lys Lys Glu Asn Gly Leu Arg Asp Ile Leu Ala Val Leu
465                 470                 475                 480 
Thr Met Lys Arg Asp Gly Ser Leu His Val Thr Cys Thr Asp Gln Glu
                485                 490                 495     
Thr Gly Lys Cys Glu Ala Ile Ser Ile Glu Ile Ala Ser
            500                 505                 


<210> 8833
<211> 447
<212> PRT
<213> Homo sapiens

<400> 8833
Met Ser Arg Arg Pro Cys Ser Cys Ala Leu Arg Pro Pro Arg Cys Ser
 1               5                  10                  15      
Cys Ser Ala Ser Pro Ser Ala Val Thr Ala Ala Gly Arg Pro Arg Pro
            20                  25                  30          
Ser Asp Ser Cys Lys Glu Glu Ser Ser Thr Leu Ser Val Lys Met Lys
        35                  40                  45              
Cys Asp Phe Asn Cys Asn His Val His Ser Gly Leu Lys Leu Val Lys
    50                  55                  60                  
Pro Asp Asp Ile Gly Arg Leu Val Ser Tyr Thr Pro Ala Tyr Leu Glu
65                  70                  75                  80  
Gly Ser Cys Lys Asp Cys Ile Lys Asp Tyr Glu Arg Leu Ser Cys Ile
                85                  90                  95      
Gly Ser Pro Ile Val Ser Pro Arg Ile Val Gln Leu Glu Thr Glu Ser
            100                 105                 110         
Lys Arg Leu His Asn Lys Glu Asn Gln His Val Gln Gln Thr Leu Asn
        115                 120                 125             
Ser Thr Asn Glu Ile Glu Ala Leu Glu Thr Ser Arg Leu Tyr Glu Asp
    130                 135                 140                 
Ser Gly Tyr Ser Ser Phe Ser Leu Gln Ser Gly Leu Ser Glu His Glu
145                 150                 155                 160 
Glu Gly Ser Leu Leu Glu Glu Asn Phe Gly Asp Ser Leu Gln Ser Cys
                165                 170                 175     
Leu Leu Gln Ile Gln Ser Pro Asp Gln Tyr Pro Asn Lys Asn Leu Leu
            180                 185                 190         
Pro Val Leu His Phe Glu Lys Val Val Cys Ser Thr Leu Lys Lys Asn
        195                 200                 205             
Ala Lys Arg Asn Pro Lys Val Asp Arg Glu Met Leu Lys Glu Ile Ile
    210                 215                 220                 
Ala Arg Gly Asn Phe Arg Leu Gln Asn Ile Ile Gly Arg Lys Met Gly
225                 230                 235                 240 
Leu Glu Cys Val Asp Ile Leu Ser Glu Leu Phe Arg Arg Gly Leu Arg
                245                 250                 255     
His Val Leu Ala Thr Ile Leu Ala Gln Leu Ser Asp Met Asp Leu Ile
            260                 265                 270         
Asn Val Ser Lys Val Ser Thr Thr Trp Lys Lys Ile Leu Glu Asp Asp
        275                 280                 285             
Lys Gly Ala Phe Gln Leu Tyr Ser Lys Ala Ile Gln Arg Val Thr Glu
    290                 295                 300                 
Asn Asn Asn Lys Phe Ser Pro His Ala Ser Thr Arg Glu Tyr Val Met
305                 310                 315                 320 
Phe Arg Thr Pro Leu Ala Ser Val Gln Lys Ser Ala Ala Gln Thr Ser
                325                 330                 335     
Leu Lys Lys Asp Ala Gln Thr Lys Leu Ser Asn Gln Gly Asp Gln Lys
            340                 345                 350         
Gly Ser Thr Tyr Ser Arg His Asn Glu Phe Ser Glu Val Ala Lys Thr
        355                 360                 365             
Leu Lys Lys Asn Glu Ser Leu Lys Ala Cys Ile Arg Cys Asn Ser Pro
    370                 375                 380                 
Ala Lys Tyr Asp Cys Tyr Leu Gln Arg Ala Thr Cys Lys Arg Glu Gly
385                 390                 395                 400 
Cys Gly Phe Asp Tyr Cys Thr Lys Cys Leu Cys Asn Tyr His Thr Thr
                405                 410                 415     
Lys Asp Cys Ser Asp Gly Lys Leu Leu Lys Ala Ser Cys Lys Ile Gly
            420                 425                 430         
Pro Leu Pro Gly Thr Lys Lys Ser Lys Lys Asn Leu Arg Arg Leu
        435                 440                 445         


<210> 8834
<211> 525
<212> PRT
<213> Homo sapiens

<400> 8834
Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala
 1               5                  10                  15      
Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro
            20                  25                  30          
Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser
        35                  40                  45              
Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Ser
    50                  55                  60                  
Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly Tyr
65                  70                  75                  80  
Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser Tyr
                85                  90                  95      
Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser Tyr
            100                 105                 110         
Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly Ser
        115                 120                 125             
Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly Gln
    130                 135                 140                 
Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln Tyr
145                 150                 155                 160 
Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asn Tyr
                165                 170                 175     
Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly Gly
            180                 185                 190         
Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr Gly
        195                 200                 205             
Gln Gln Asp Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly Gly Gly
    210                 215                 220                 
Gly Gly Gly Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly Tyr Glu Pro
225                 230                 235                 240 
Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Met Gly Gly Ser
                245                 250                 255     
Asp Arg Gly Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp Gln Gly Ser
            260                 265                 270         
Arg His Asp Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr Ile Phe Val
        275                 280                 285             
Gln Gly Leu Gly Glu Asn Val Thr Ile Glu Ser Val Ala Asp Tyr Phe
    290                 295                 300                 
Lys Gln Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Gln Pro Met
305                 310                 315                 320 
Ile Asn Leu Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys Gly Glu Ala
                325                 330                 335     
Thr Val Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp Trp
            340                 345                 350         
Phe Asp Gly Lys Glu Phe Ser Gly Asn Pro Ile Lys Val Ser Phe Ala
        355                 360                 365             
Thr Arg Arg Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly Arg Gly Gly
    370                 375                 380                 
Arg Gly Arg Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly Gly Gly Gly
385                 390                 395                 400 
Ser Gly Gly Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly Gly Gly Gly
                405                 410                 415     
Gly Gly Gln Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn Pro Thr Cys
            420                 425                 430         
Glu Asn Met Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln Cys Lys Ala
        435                 440                 445             
Pro Lys Pro Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser His Met Gly
    450                 455                 460                 
Gly Asn Tyr Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly Tyr Asp Arg
465                 470                 475                 480 
Gly Gly Tyr Arg Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg Gly Gly
                485                 490                 495     
Arg Gly Gly Gly Asp Arg Gly Gly Phe Gly Pro Gly Lys Met Asp Ser
            500                 505                 510         
Arg Gly Glu His Arg Gln Asp Arg Arg Glu Arg Pro Tyr
        515                 520                 525 


<210> 8835
<211> 553
<212> PRT
<213> Homo sapiens

<400> 8835
Gly Leu Leu Ser Pro Pro Gly Val Gly Thr Gln Arg Cys Trp Asn Phe
 1               5                  10                  15      
Val Ala Cys Leu Pro Val Arg Ala Cys Ala Asp Met Ala Ser Asn Asp
            20                  25                  30          
Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala Tyr Pro Thr Gln Pro
        35                  40                  45              
Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro Tyr Gly Gln Gln Ser
    50                  55                  60                  
Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser Gly Tyr Gly Gln Ser
65                  70                  75                  80  
Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Thr Gly Tyr Gly Thr Gln
                85                  90                  95      
Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly Tyr Gly Ser Ser Gln
            100                 105                 110         
Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser Tyr Pro Gly Tyr Gly
        115                 120                 125             
Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser Tyr Gly Ser Ser Ser
    130                 135                 140                 
Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly Ser Tyr Ser Gln Gln
145                 150                 155                 160 
Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly Gln Gln Gln Ser Tyr
                165                 170                 175     
Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln Tyr Asn Ser Ser Ser
            180                 185                 190         
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asn Tyr Gly Gln Asp Gln
        195                 200                 205             
Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly Gly Tyr Gly Asn Gln
    210                 215                 220                 
Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr Gly Gln Gln Asp Arg
225                 230                 235                 240 
Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly
                245                 250                 255     
Gly Gly Tyr Asn Arg Ser Ser Gly Gly Tyr Glu Pro Arg Gly Arg Gly
            260                 265                 270         
Gly Gly Arg Gly Gly Arg Gly Gly Met Gly Gly Ser Asp Arg Gly Gly
        275                 280                 285             
Phe Asn Lys Phe Gly Gly Pro Arg Asp Gln Gly Ser Arg His Asp Ser
    290                 295                 300                 
Glu Gln Asp Asn Ser Asp Asn Asn Thr Ile Phe Val Gln Gly Leu Gly
305                 310                 315                 320 
Glu Asn Val Thr Ile Glu Ser Val Ala Asp Tyr Phe Lys Gln Ile Gly
                325                 330                 335     
Ile Ile Lys Thr Asn Lys Lys Thr Gly Gln Pro Met Ile Asn Leu Tyr
            340                 345                 350         
Thr Asp Arg Glu Thr Gly Lys Leu Lys Gly Glu Ala Thr Val Ser Phe
        355                 360                 365             
Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp Trp Phe Asp Gly Lys
    370                 375                 380                 
Glu Phe Ser Gly Asn Pro Ile Lys Val Ser Phe Ala Thr Arg Arg Ala
385                 390                 395                 400 
Asp Phe Asn Arg Gly Gly Gly Asn Gly Arg Gly Gly Arg Gly Arg Gly
                405                 410                 415     
Gly Pro Met Gly Arg Gly Gly Tyr Gly Gly Gly Gly Ser Gly Gly Gly
            420                 425                 430         
Gly Arg Gly Gly Phe Pro Ser Gly Gly Gly Gly Gly Gly Gly Gln Gln
        435                 440                 445             
Arg Ala Gly Asp Trp Lys Cys Pro Asn Pro Thr Cys Glu Asn Met Asn
    450                 455                 460                 
Phe Ser Trp Arg Asn Glu Cys Asn Gln Cys Lys Ala Pro Lys Pro Asp
465                 470                 475                 480 
Gly Pro Gly Gly Gly Pro Gly Gly Ser His Met Gly Gly Asn Tyr Gly
                485                 490                 495     
Asp Asp Arg Arg Gly Gly Arg Gly Gly Tyr Asp Arg Gly Gly Tyr Arg
            500                 505                 510         
Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Gly
        515                 520                 525             
Asp Arg Gly Gly Phe Gly Pro Gly Lys Met Asp Ser Arg Gly Glu His
    530                 535                 540                 
Arg Gln Asp Arg Arg Glu Arg Pro Tyr
545                 550             


<210> 8836
<211> 638
<212> PRT
<213> Homo sapiens

<400> 8836
Met Leu Asp Phe Phe Thr Ile Phe Ser Lys Gly Gly Leu Val Leu Trp
 1               5                  10                  15      
Cys Phe Gln Gly Val Ser Asp Ser Cys Thr Gly Pro Val Asn Ala Leu
            20                  25                  30          
Ile Arg Ser Val Leu Leu Gln Glu Arg Gly Gly Asn Asn Ser Phe Thr
        35                  40                  45              
His Glu Ala Leu Thr Leu Lys Tyr Lys Leu Asp Asn Gln Phe Glu Leu
    50                  55                  60                  
Val Phe Val Val Gly Phe Gln Lys Ile Leu Thr Leu Thr Tyr Val Asp
65                  70                  75                  80  
Lys Leu Ile Asp Asp Val His Arg Leu Phe Arg Asp Lys Tyr Arg Thr
                85                  90                  95      
Glu Ile Gln Gln Gln Ser Ala Leu Ser Leu Leu Asn Gly Thr Phe Asp
            100                 105                 110         
Phe Gln Asn Asp Phe Leu Arg Leu Leu Arg Glu Ala Glu Glu Ser Ser
        115                 120                 125             
Lys Ile Arg Ala Pro Thr Thr Met Lys Lys Phe Glu Asp Ser Glu Lys
    130                 135                 140                 
Ala Lys Lys Pro Val Arg Ser Met Ile Glu Thr Arg Gly Glu Lys Pro
145                 150                 155                 160 
Lys Glu Lys Ala Lys Asn Ser Lys Lys Lys Gly Ala Lys Lys Glu Gly
                165                 170                 175     
Ser Asp Gly Pro Leu Ala Thr Ser Lys Pro Val Pro Ala Glu Lys Ser
            180                 185                 190         
Gly Leu Pro Val Gly Pro Glu Asn Gly Val Glu Leu Ser Lys Glu Glu
        195                 200                 205             
Leu Ile Arg Arg Lys Arg Glu Glu Phe Ile Gln Lys His Gly Arg Gly
    210                 215                 220                 
Met Glu Lys Ser Asn Lys Ser Thr Lys Ser Asp Ala Pro Lys Glu Lys
225                 230                 235                 240 
Gly Lys Lys Ala Pro Arg Val Trp Glu Leu Gly Gly Cys Ala Asn Lys
                245                 250                 255     
Glu Val Leu Asp Tyr Ser Thr Pro Thr Thr Asn Gly Thr Pro Glu Ala
            260                 265                 270         
Ala Leu Ser Glu Asp Ile Asn Leu Ile Arg Gly Thr Gly Ser Gly Gly
        275                 280                 285             
Gln Leu Gln Asp Leu Asp Cys Ser Ser Ser Asp Asp Glu Gly Ala Ala
    290                 295                 300                 
Gln Asn Ser Thr Lys Pro Ser Ala Thr Lys Gly Thr Leu Gly Gly Met
305                 310                 315                 320 
Phe Gly Met Leu Lys Gly Leu Val Gly Ser Lys Ser Leu Ser Arg Glu
                325                 330                 335     
Asp Met Glu Ser Val Leu Asp Lys Met Arg Asp His Leu Ile Ala Lys
            340                 345                 350         
Asn Val Ala Ala Asp Ile Ala Val Gln Leu Cys Glu Ser Val Ala Asn
        355                 360                 365             
Lys Leu Glu Gly Lys Val Met Gly Thr Phe Ser Thr Val Thr Ser Thr
    370                 375                 380                 
Val Lys Gln Ala Leu Gln Glu Ser Leu Val Gln Ile Leu Gln Pro Gln
385                 390                 395                 400 
Arg Arg Val Asp Met Leu Arg Asp Ile Met Asp Ala Gln Arg Arg Gln
                405                 410                 415     
Arg Pro Tyr Val Val Thr Phe Cys Gly Val Asn Gly Val Gly Lys Ser
            420                 425                 430         
Thr Asn Leu Ala Lys Ile Ser Phe Trp Leu Leu Glu Asn Gly Phe Ser
        435                 440                 445             
Val Leu Ile Ala Ala Cys Asp Thr Phe Arg Ala Gly Ala Val Glu Gln
    450                 455                 460                 
Leu Arg Thr His Thr Arg Arg Leu Ser Ala Leu His Pro Pro Glu Lys
465                 470                 475                 480 
His Gly Gly Arg Thr Met Val Gln Leu Phe Glu Lys Gly Tyr Gly Lys
                485                 490                 495     
Asp Ala Ala Gly Ile Ala Met Glu Ala Ile Ala Phe Ala Arg Asn Gln
            500                 505                 510         
Gly Phe Asp Val Val Leu Val Asp Thr Ala Gly Arg Met Gln Asp Asn
        515                 520                 525             
Ala Pro Leu Met Thr Ala Leu Ala Lys Leu Ile Thr Val Asn Thr Pro
    530                 535                 540                 
Asp Leu Val Leu Phe Val Gly Glu Ala Leu Val Gly Asn Glu Ala Val
545                 550                 555                 560 
Asp Gln Leu Val Lys Phe Asn Arg Ala Leu Ala Asp His Ser Met Ala
                565                 570                 575     
Gln Thr Pro Arg Leu Ile Asp Gly Ile Val Leu Thr Lys Phe Asp Thr
            580                 585                 590         
Ile Asp Asp Lys Val Gly Ala Ala Ile Ser Met Thr Tyr Ile Thr Ser
        595                 600                 605             
Lys Pro Ile Val Phe Val Gly Thr Gly Gln Thr Tyr Cys Asp Leu Arg
    610                 615                 620                 
Ser Leu Asn Ala Lys Ala Val Val Ala Ala Leu Met Lys Ala
625                 630                 635             


<210> 8837
<211> 471
<212> PRT
<213> Homo sapiens

<400> 8837
Leu Ser Ala Ser Pro Gly Cys Gly Leu Arg Val Arg Ala Arg Pro Arg
 1               5                  10                  15      
Trp Ser Arg Trp Arg Cys Cys Gly Cys Trp Gly Cys Arg Gly Pro Gly
            20                  25                  30          
Ala Arg Gln Arg Arg Ser Ala Cys Thr Trp Ala Ala Ala Ala Gly Ala
        35                  40                  45              
Ser Cys Ala Ser Ser Ala Arg Pro Arg Gly Glu Thr Ser Tyr Arg Leu
    50                  55                  60                  
Phe Tyr Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Ile
65                  70                  75                  80  
Val Val His Ser Arg Tyr Tyr Arg Met Ala Ala Phe Gly His His Ala
                85                  90                  95      
Tyr Arg Met Gln Ala Ala Asp Val Leu Tyr Asp Cys Leu Pro Leu Tyr
            100                 105                 110         
His Ser Ala Gly Asn Ile Ile Gly Val Gly Gln Cys Leu Ile Tyr Gly
        115                 120                 125             
Leu Thr Val Val Leu Arg Lys Lys Phe Ser Ala Ser Arg Phe Trp Asp
    130                 135                 140                 
Asp Cys Ile Lys Tyr Asn Cys Thr Val Val Gln Tyr Ile Gly Glu Ile
145                 150                 155                 160 
Cys Arg Tyr Leu Leu Lys Gln Pro Val Arg Glu Ala Glu Arg Arg His
                165                 170                 175     
Arg Val Arg Leu Ala Val Gly Asn Gly Leu Arg Pro Ala Ile Trp Glu
            180                 185                 190         
Glu Phe Thr Glu Arg Phe Gly Val Arg Gln Ile Gly Glu Phe Tyr Gly
        195                 200                 205             
Ala Thr Glu Cys Asn Cys Ser Ile Ala Asn Met Asp Gly Lys Val Gly
    210                 215                 220                 
Ser Cys Gly Phe Asn Ser Arg Ile Leu Pro His Val Tyr Pro Ile Arg
225                 230                 235                 240 
Leu Val Lys Val Asn Glu Asp Thr Met Glu Leu Leu Arg Asp Ala Gln
                245                 250                 255     
Gly Leu Cys Ile Pro Cys Gln Ala Gly Glu Pro Gly Leu Leu Val Gly
            260                 265                 270         
Gln Ile Asn Gln Gln Asp Pro Leu Arg Arg Phe Asp Gly Tyr Val Ser
        275                 280                 285             
Glu Ser Ala Thr Ser Lys Lys Ile Ala His Ser Val Phe Ser Lys Gly
    290                 295                 300                 
Asp Ser Ala Tyr Leu Ser Gly Asp Val Leu Val Met Asp Glu Leu Gly
305                 310                 315                 320 
Tyr Met Tyr Phe Arg Asp Arg Ser Gly Asp Thr Phe Arg Trp Arg Gly
                325                 330                 335     
Glu Asn Val Ser Thr Thr Glu Val Glu Gly Val Leu Ser Arg Leu Leu
            340                 345                 350         
Gly Gln Thr Asp Val Ala Val Tyr Gly Val Ala Val Pro Gly Lys Leu
        355                 360                 365             
Gly Leu Gln Gly Val Val Leu Arg His Gly Val Glu Gly Lys Ala Gly
    370                 375                 380                 
Met Ala Ala Val Ala Asp Pro His Ser Leu Leu Asp Pro Asn Ala Ile
385                 390                 395                 400 
Tyr Gln Glu Leu Gln Lys Val Leu Ala Pro Tyr Ala Arg Pro Ile Phe
                405                 410                 415     
Leu Arg Leu Leu Pro Gln Val Asp Thr Thr Gly Thr Phe Lys Ile Gln
            420                 425                 430         
Lys Thr Arg Leu Gln Arg Glu Gly Phe Asp Pro Arg Gln Thr Ser Asp
        435                 440                 445             
Arg Leu Phe Phe Leu Asp Leu Lys Gln Gly His Tyr Leu Pro Leu Asn
    450                 455                 460                 
Glu Ala Val Tyr Thr Arg Ile
465                 470     


<210> 8838
<211> 682
<212> PRT
<213> Homo sapiens

<400> 8838
Met Arg Ala Pro Gly Ala Gly Ala Ala Ser Val Val Ser Leu Ala Leu
 1               5                  10                  15      
Leu Trp Leu Leu Gly Leu Pro Trp Thr Trp Ser Ala Ala Ala Ala Leu
            20                  25                  30          
Gly Val Tyr Val Gly Ser Gly Gly Trp Arg Phe Leu Arg Ile Val Cys
        35                  40                  45              
Lys Thr Ala Arg Arg Asp Leu Phe Gly Leu Ser Val Leu Ile Arg Val
    50                  55                  60                  
Arg Leu Glu Leu Arg Arg His Gln Arg Ala Gly His Thr Ile Pro Arg
65                  70                  75                  80  
Ile Phe Gln Ala Val Val Gln Arg Gln Pro Glu Arg Leu Ala Leu Val
                85                  90                  95      
Asp Ala Gly Thr Gly Glu Cys Trp Thr Phe Ala Gln Leu Asp Ala Tyr
            100                 105                 110         
Ser Asn Ala Val Ala Asn Leu Phe Arg Gln Leu Gly Phe Ala Pro Gly
        115                 120                 125             
Asp Val Val Ala Ile Phe Leu Glu Gly Arg Pro Glu Phe Val Gly Leu
    130                 135                 140                 
Trp Leu Gly Leu Ala Lys Ala Gly Met Glu Ala Ala Leu Leu Asn Val
145                 150                 155                 160 
Asn Leu Arg Arg Glu Pro Leu Ala Phe Cys Leu Gly Thr Ser Gly Ala
                165                 170                 175     
Lys Ala Leu Ile Phe Gly Gly Glu Met Val Ala Ala Val Ala Glu Val
            180                 185                 190         
Ser Gly His Leu Gly Lys Ser Leu Ile Lys Phe Cys Ser Gly Asp Leu
        195                 200                 205             
Gly Pro Glu Gly Ile Leu Pro Asp Thr His Leu Leu Asp Pro Leu Leu
    210                 215                 220                 
Lys Glu Ala Ser Thr Ala Pro Leu Ala Gln Ile Pro Ser Lys Gly Met
225                 230                 235                 240 
Asp Gly Pro Ala Pro Asn Phe Gln Ala Pro Pro Pro Asn Ala Gln Ala
                245                 250                 255     
Pro Pro Leu Thr Pro Val Ser Pro Ala Asp Arg Leu Phe Tyr Ile Tyr
            260                 265                 270         
Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Ile Val Val His Ser
        275                 280                 285             
Arg Tyr Tyr Arg Met Ala Ala Phe Gly His His Ala Tyr Arg Met Gln
    290                 295                 300                 
Ala Ala Asp Val Leu Tyr Asp Cys Leu Pro Leu Tyr His Ser Ala Gly
305                 310                 315                 320 
Asn Ile Ile Gly Val Gly Gln Cys Leu Ile Tyr Gly Leu Thr Val Val
                325                 330                 335     
Leu Arg Lys Lys Phe Ser Ala Ser Arg Phe Trp Asp Asp Cys Ile Lys
            340                 345                 350         
Tyr Asn Cys Thr Val Val Gln Tyr Ile Gly Glu Ile Cys Arg Tyr Leu
        355                 360                 365             
Leu Lys Gln Pro Val Arg Glu Ala Glu Arg Arg His Arg Val Arg Leu
    370                 375                 380                 
Ala Val Gly Asn Gly Leu Arg Pro Ala Ile Trp Glu Glu Phe Thr Glu
385                 390                 395                 400 
Arg Phe Gly Val Arg Gln Ile Gly Glu Phe Tyr Gly Ala Thr Glu Cys
                405                 410                 415     
Asn Cys Ser Ile Ala Asn Met Asp Gly Lys Val Gly Ser Cys Gly Phe
            420                 425                 430         
Asn Ser Arg Ile Leu Pro His Val Tyr Pro Ile Arg Leu Val Lys Val
        435                 440                 445             
Asn Glu Asp Thr Met Glu Leu Leu Arg Asp Ala Gln Gly Leu Cys Ile
    450                 455                 460                 
Pro Cys Gln Ala Gly Glu Pro Gly Leu Leu Val Gly Gln Ile Asn Gln
465                 470                 475                 480 
Gln Asp Pro Leu Arg Arg Phe Asp Gly Tyr Val Ser Glu Ser Ala Thr
                485                 490                 495     
Ser Lys Lys Ile Ala His Ser Val Phe Ser Lys Gly Asp Ser Ala Tyr
            500                 505                 510         
Leu Ser Gly Asp Val Leu Val Met Asp Glu Leu Gly Tyr Met Tyr Phe
        515                 520                 525             
Arg Asp Arg Ser Gly Asp Thr Phe Arg Trp Arg Gly Glu Asn Val Ser
    530                 535                 540                 
Thr Thr Glu Val Glu Gly Val Leu Ser Arg Leu Leu Gly Gln Thr Asp
545                 550                 555                 560 
Val Ala Val Tyr Gly Val Ala Val Pro Gly Lys Leu Gly Leu Gln Gly
                565                 570                 575     
Val Val Leu Arg His Gly Val Glu Gly Lys Ala Gly Met Ala Ala Val
            580                 585                 590         
Ala Asp Pro His Ser Leu Leu Asp Pro Asn Ala Ile Tyr Gln Glu Leu
        595                 600                 605             
Gln Lys Val Leu Ala Pro Tyr Ala Arg Pro Ile Phe Leu Arg Leu Leu
    610                 615                 620                 
Pro Gln Val Asp Thr Thr Gly Thr Phe Lys Ile Gln Lys Thr Arg Leu
625                 630                 635                 640 
Gln Arg Glu Gly Phe Asp Pro Arg Gln Thr Ser Asp Arg Leu Phe Phe
                645                 650                 655     
Leu Asp Leu Lys Gln Gly His Tyr Leu Pro Leu Asn Glu Ala Val Tyr
            660                 665                 670         
Thr Arg Ile Cys Ser Gly Ala Phe Ala Leu
        675                 680         


<210> 8839
<211> 412
<212> PRT
<213> Homo sapiens

<400> 8839
Met Ala Ala Ala Leu Leu Ala Arg Ala Ser Gly Pro Ala Arg Arg Ala
 1               5                  10                  15      
Leu Cys Pro Arg Ala Trp Arg Gln Leu His Thr Ile Tyr Gln Ser Val
            20                  25                  30          
Glu Leu Pro Glu Thr His Gln Met Leu Leu Gln Thr Cys Arg Asp Phe
        35                  40                  45              
Ala Glu Lys Glu Leu Phe Pro Ile Ala Ala Gln Val Asp Lys Glu His
    50                  55                  60                  
Leu Phe Pro Ala Ala Gln Val Lys Lys Met Gly Gly Leu Gly Leu Leu
65                  70                  75                  80  
Ala Met Asp Val Pro Glu Glu Leu Gly Gly Ala Gly Leu Asp Tyr Leu
                85                  90                  95      
Ala Tyr Ala Ile Ala Met Glu Glu Ile Ser Arg Gly Cys Ala Ser Thr
            100                 105                 110         
Gly Val Ile Met Ser Val Asn Asn Ser Leu Tyr Leu Gly Pro Ile Leu
        115                 120                 125             
Lys Phe Gly Ser Lys Glu Gln Lys Gln Ala Trp Val Thr Pro Phe Thr
    130                 135                 140                 
Ser Gly Asp Lys Ile Gly Cys Phe Ala Leu Ser Glu Pro Gly Asn Gly
145                 150                 155                 160 
Ser Asp Ala Gly Ala Ala Ser Thr Thr Ala Arg Ala Glu Gly Asp Ser
                165                 170                 175     
Trp Val Leu Asn Gly Thr Lys Ala Trp Ile Thr Asn Ala Trp Glu Ala
            180                 185                 190         
Ser Ala Ala Val Val Phe Ala Ser Thr Asp Arg Ala Leu Gln Asn Lys
        195                 200                 205             
Gly Ile Ser Ala Phe Leu Val Pro Met Pro Thr Pro Gly Leu Thr Leu
    210                 215                 220                 
Gly Lys Lys Glu Asp Lys Leu Gly Ile Arg Gly Ser Ser Thr Ala Asn
225                 230                 235                 240 
Leu Ile Phe Glu Asp Cys Arg Ile Pro Lys Asp Ser Ile Leu Gly Glu
                245                 250                 255     
Pro Gly Met Gly Phe Lys Ile Ala Met Gln Thr Leu Asp Met Gly Arg
            260                 265                 270         
Ile Gly Ile Ala Ser Gln Ala Leu Gly Ile Ala Gln Thr Ala Leu Asp
        275                 280                 285             
Cys Ala Val Asn Tyr Ala Glu Asn Arg Met Ala Phe Gly Ala Pro Leu
    290                 295                 300                 
Thr Lys Leu Gln Val Ile Gln Phe Lys Leu Ala Asp Met Ala Leu Ala
305                 310                 315                 320 
Leu Glu Ser Ala Arg Leu Leu Thr Trp Arg Ala Ala Met Leu Lys Asp
                325                 330                 335     
Asn Lys Lys Pro Phe Ile Lys Glu Ala Ala Met Ala Lys Leu Ala Ala
            340                 345                 350         
Ser Glu Ala Ala Thr Ala Ile Ser His Gln Ala Ile Gln Ile Leu Gly
        355                 360                 365             
Gly Met Gly Tyr Val Thr Glu Met Pro Ala Glu Arg His Tyr Arg Asp
    370                 375                 380                 
Ala Arg Ile Thr Glu Ile Tyr Glu Gly Thr Ser Glu Ile Gln Arg Leu
385                 390                 395                 400 
Val Ile Ala Gly His Leu Leu Arg Ser Tyr Arg Ser
                405                 410         


<210> 8840
<211> 728
<212> PRT
<213> Homo sapiens

<400> 8840
Leu Glu Phe Lys Ser Gly Gly Cys Gly Ala Gly Leu Val Ala Ala Gly
 1               5                  10                  15      
Ala Val Arg Val Leu Tyr Pro Ala Ser Arg Ala Gly Glu Arg Thr Arg
            20                  25                  30          
Val Pro Gly Ser Pro Ala Pro Ser Ser Leu Pro Leu His Ser Pro Gly
        35                  40                  45              
Ala Cys Gly Thr Glu Val Asp Met Asp Pro Gln Arg Ser Pro Leu Leu
    50                  55                  60                  
Glu Val Lys Gly Asn Ile Glu Leu Lys Arg Pro Leu Ile Lys Ala Pro
65                  70                  75                  80  
Ser Gln Leu Pro Leu Ser Gly Ser Arg Leu Lys Arg Arg Pro Asp Gln
                85                  90                  95      
Met Glu Asp Gly Leu Glu Pro Glu Lys Lys Arg Thr Arg Gly Leu Gly
            100                 105                 110         
Ala Thr Thr Lys Ile Thr Thr Ser His Pro Arg Val Pro Ser Leu Thr
        115                 120                 125             
Thr Val Pro Gln Thr Gln Gly Gln Thr Thr Ala Gln Lys Val Ser Lys
    130                 135                 140                 
Lys Thr Gly Pro Arg Cys Ser Thr Ala Ile Ala Thr Gly Leu Lys Asn
145                 150                 155                 160 
Gln Lys Pro Val Pro Ala Val Pro Val Gln Lys Ser Gly Thr Ser Gly
                165                 170                 175     
Val Pro Pro Met Ala Gly Gly Lys Lys Pro Ser Lys Arg Pro Ala Trp
            180                 185                 190         
Asp Leu Lys Gly Gln Leu Cys Asp Leu Asn Ala Glu Leu Lys Arg Cys
        195                 200                 205             
Arg Glu Arg Thr Gln Thr Leu Asp Gln Glu Asn Gln Gln Leu Gln Asp
    210                 215                 220                 
Gln Leu Arg Asp Ala Gln Gln Gln Val Lys Ala Leu Gly Thr Glu Arg
225                 230                 235                 240 
Thr Thr Leu Glu Gly His Leu Ala Lys Val Gln Ala Gln Ala Glu Gln
                245                 250                 255     
Gly Gln Gln Glu Leu Lys Asn Leu Arg Ala Cys Val Leu Glu Leu Glu
            260                 265                 270         
Glu Arg Leu Ser Thr Gln Glu Gly Leu Val Gln Glu Leu Gln Lys Lys
        275                 280                 285             
Gln Val Glu Leu Gln Glu Glu Arg Arg Gly Leu Met Ser Gln Leu Glu
    290                 295                 300                 
Glu Lys Glu Arg Arg Leu Gln Thr Ser Glu Ala Ala Leu Ser Ser Ser
305                 310                 315                 320 
Gln Ala Glu Val Ala Ser Leu Arg Gln Glu Thr Val Ala Gln Ala Ala
                325                 330                 335     
Leu Leu Thr Glu Arg Glu Glu Arg Leu His Gly Leu Glu Met Glu Arg
            340                 345                 350         
Arg Arg Leu His Asn Gln Leu Gln Glu Leu Lys Gly Asn Ile Arg Val
        355                 360                 365             
Phe Cys Arg Val Arg Pro Val Leu Pro Gly Glu Pro Thr Pro Pro Pro
    370                 375                 380                 
Gly Leu Leu Leu Phe Pro Ser Gly Pro Gly Gly Pro Ser Asp Pro Pro
385                 390                 395                 400 
Thr Arg Leu Ser Leu Ser Arg Ser Asp Glu Arg Arg Gly Thr Leu Ser
                405                 410                 415     
Gly Ala Pro Ala Pro Pro Thr Arg His Asp Phe Ser Phe Asp Arg Val
            420                 425                 430         
Phe Pro Pro Gly Ser Gly Gln Asp Glu Val Phe Glu Glu Ile Ala Met
        435                 440                 445             
Leu Val Gln Ser Ala Leu Asp Gly Tyr Pro Val Cys Ile Phe Ala Tyr
    450                 455                 460                 
Gly Gln Thr Gly Ser Gly Lys Thr Phe Thr Met Glu Gly Gly Pro Gly
465                 470                 475                 480 
Gly Asp Pro Gln Leu Glu Gly Leu Ile Pro Arg Ala Leu Arg His Leu
                485                 490                 495     
Phe Ser Val Ala Gln Glu Leu Ser Gly Gln Gly Trp Thr Tyr Ser Phe
            500                 505                 510         
Val Ala Ser Tyr Val Glu Ile Tyr Asn Glu Thr Val Arg Asp Leu Leu
        515                 520                 525             
Ala Thr Gly Thr Arg Lys Gly Gln Gly Gly Glu Cys Glu Ile Arg Arg
    530                 535                 540                 
Ala Gly Pro Gly Ser Glu Glu Leu Thr Val Thr Asn Ala Arg Tyr Val
545                 550                 555                 560 
Pro Val Ser Cys Glu Lys Glu Val Asp Ala Leu Leu His Leu Ala Arg
                565                 570                 575     
Gln Asn Arg Ala Val Ala Arg Thr Ala Gln Asn Glu Arg Ser Ser Arg
            580                 585                 590         
Ser His Ser Val Phe Gln Leu Gln Ile Ser Gly Glu His Ser Ser Arg
        595                 600                 605             
Gly Leu Gln Cys Gly Ala Pro Leu Ser Leu Val Asp Leu Ala Gly Ser
    610                 615                 620                 
Glu Arg Leu Asp Pro Gly Leu Ala Leu Gly Pro Gly Glu Arg Glu Arg
625                 630                 635                 640 
Leu Arg Glu Thr Gln Ala Ile Asn Ser Ser Leu Ser Thr Leu Gly Leu
                645                 650                 655     
Val Ile Met Ala Leu Ser Asn Lys Glu Ser His Val Pro Tyr Arg Asn
            660                 665                 670         
Ser Lys Leu Thr Tyr Leu Leu Gln Asn Ser Leu Gly Gly Ser Ala Lys
        675                 680                 685             
Met Leu Met Phe Val Asn Ile Ser Pro Leu Glu Glu Asn Val Ser Glu
    690                 695                 700                 
Ser Leu Asn Ser Leu Arg Phe Ala Ser Lys Val Asn Gln Cys Val Ile
705                 710                 715                 720 
Gly Thr Ala Gln Ala Asn Arg Lys
                725             


<210> 8841
<211> 457
<212> PRT
<213> Homo sapiens

<400> 8841
Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His
 1               5                  10                  15      
His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala
            20                  25                  30          
Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln
        35                  40                  45              
Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg
    50                  55                  60                  
Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr
65                  70                  75                  80  
Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met
                85                  90                  95      
Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys
            100                 105                 110         
Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln
        115                 120                 125             
His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly
    130                 135                 140                 
Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln
145                 150                 155                 160 
Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu
                165                 170                 175     
Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe
            180                 185                 190         
His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His
        195                 200                 205             
Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser
    210                 215                 220                 
Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu
225                 230                 235                 240 
Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His
                245                 250                 255     
Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu
            260                 265                 270         
Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys
        275                 280                 285             
Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro
    290                 295                 300                 
Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn
305                 310                 315                 320 
Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro
                325                 330                 335     
Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile
            340                 345                 350         
Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val
        355                 360                 365             
Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe
    370                 375                 380                 
Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp
385                 390                 395                 400 
Gly Asn Phe Val Phe Phe Lys Val Lys Gly Asp Thr Leu Ser Val Ile
                405                 410                 415     
Gln Asp Gly Trp Leu Tyr Lys Tyr His Trp Lys Trp Ile Leu Glu Gln
            420                 425                 430         
Arg Gln Ser Val Pro Val Leu Ser Arg Gln Thr Glu Lys His Lys Thr
        435                 440                 445             
Tyr Glu Glu Leu Ser Ser Ile Thr Tyr
    450                 455         


<210> 8842
<211> 607
<212> PRT
<213> Homo sapiens

<400> 8842
Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His
 1               5                  10                  15      
His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala
            20                  25                  30          
Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln
        35                  40                  45              
Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg
    50                  55                  60                  
Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr
65                  70                  75                  80  
Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met
                85                  90                  95      
Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys
            100                 105                 110         
Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln
        115                 120                 125             
His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly
    130                 135                 140                 
Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln
145                 150                 155                 160 
Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu
                165                 170                 175     
Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe
            180                 185                 190         
His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His
        195                 200                 205             
Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser
    210                 215                 220                 
Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu
225                 230                 235                 240 
Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His
                245                 250                 255     
Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu
            260                 265                 270         
Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys
        275                 280                 285             
Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro
    290                 295                 300                 
Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn
305                 310                 315                 320 
Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro
                325                 330                 335     
Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile
            340                 345                 350         
Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val
        355                 360                 365             
Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe
    370                 375                 380                 
Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp
385                 390                 395                 400 
Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp
                405                 410                 415     
Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser
            420                 425                 430         
Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val
        435                 440                 445             
Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu
    450                 455                 460                 
Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp
465                 470                 475                 480 
Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn
                485                 490                 495     
Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn
            500                 505                 510         
Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp
        515                 520                 525             
Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser
    530                 535                 540                 
Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser
545                 550                 555                 560 
Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys
                565                 570                 575     
Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr
            580                 585                 590         
Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val
        595                 600                 605         


<210> 8843
<211> 587
<212> PRT
<213> Homo sapiens

<400> 8843
Met Ala Ala Ala Val Ala Val Ala Ala Ala Ser Arg Arg Gln Ser Cys
 1               5                  10                  15      
Tyr Leu Cys Asp Leu Pro Arg Met Pro Trp Ala Met Ile Trp Asp Phe
            20                  25                  30          
Thr Glu Pro Val Cys Arg Gly Cys Val Asn Tyr Glu Gly Ala Asp Arg
        35                  40                  45              
Val Glu Phe Val Ile Glu Thr Ala Arg Gln Leu Lys Arg Ala His Gly
    50                  55                  60                  
Cys Phe Pro Glu Gly Arg Ser Pro Pro Gly Ala Ala Ala Ser Ala Ala
65                  70                  75                  80  
Ala Lys Pro Pro Pro Leu Ser Ala Lys Asp Ile Leu Leu Gln Gln Gln
                85                  90                  95      
Gln Gln Leu Gly His Gly Gly Pro Glu Ala Ala Pro Arg Ala Pro Gln
            100                 105                 110         
Ala Leu Glu Arg Tyr Pro Leu Ala Ala Ala Ala Glu Arg Pro Pro Arg
        115                 120                 125             
Leu Gly Ser Asp Phe Gly Ser Ser Arg Pro Ala Ala Ser Leu Ala Gln
    130                 135                 140                 
Pro Pro Thr Pro Gln Pro Pro Pro Val Asn Gly Ile Leu Val Pro Asn
145                 150                 155                 160 
Gly Phe Ser Lys Leu Glu Glu Pro Pro Glu Leu Asn Arg Gln Ser Pro
                165                 170                 175     
Lys Pro Arg Arg Gly His Thr Val Pro Pro Thr Leu Val Pro Leu Met
            180                 185                 190         
Asn Gly Ser Ala Thr Pro Leu Pro Thr Ala Leu Gly Leu Gly Gly Arg
        195                 200                 205             
Ala Ala Ala Ser Leu Ala Ala Val Ser Gly Thr Ala Ala Ala Ser Leu
    210                 215                 220                 
Gly Ser Ala Gln Pro Thr Asp Leu Gly Ala His Lys Arg Pro Ala Ser
225                 230                 235                 240 
Val Ser Ser Ser Ala Thr Val Glu His Glu Gln Arg Glu Ala Ala Ala
                245                 250                 255     
Lys Glu Lys Gln Pro Pro Pro Pro Ala His Arg Gly Pro Ala Asp Ser
            260                 265                 270         
Leu Ser Thr Ala Ala Gly Ala Ala Glu Leu Ser Ala Glu Gly Ala Gly
        275                 280                 285             
Lys Ser Arg Gly Ser Gly Glu Gln Asp Trp Val Asn Arg Pro Lys Thr
    290                 295                 300                 
Val Arg Asp Thr Leu Leu Ala Leu His Gln His Gly His Ser Gly Pro
305                 310                 315                 320 
Phe Glu Ser Lys Phe Lys Lys Glu Pro Ala Leu Thr Ala Gly Arg Leu
                325                 330                 335     
Leu Gly Phe Glu Ala Asn Gly Ala Asn Gly Ser Lys Ala Val Ala Arg
            340                 345                 350         
Thr Ala Arg Lys Arg Lys Pro Ser Pro Glu Pro Glu Gly Glu Val Gly
        355                 360                 365             
Pro Pro Lys Ile Asn Gly Glu Ala Gln Pro Trp Leu Ser Thr Ser Thr
    370                 375                 380                 
Glu Gly Leu Lys Ile Pro Met Thr Pro Thr Ser Ser Phe Val Ser Pro
385                 390                 395                 400 
Pro Pro Pro Thr Ala Ser Pro His Ser Asn Arg Thr Thr Pro Pro Glu
                405                 410                 415     
Ala Ala Gln Asn Gly Gln Ser Pro Met Ala Ala Leu Ile Leu Val Ala
            420                 425                 430         
Asp Asn Ala Gly Gly Ser His Ala Ser Lys Asp Ala Asn Gln Val His
        435                 440                 445             
Ser Thr Thr Arg Arg Asn Ser Asn Ser Pro Pro Ser Pro Ser Ser Met
    450                 455                 460                 
Asn Gln Arg Arg Leu Gly Pro Arg Glu Val Gly Gly Gln Gly Ala Gly
465                 470                 475                 480 
Asn Thr Gly Gly Leu Glu Pro Val His Pro Ala Ser Leu Pro Asp Ser
                485                 490                 495     
Ser Leu Ala Thr Ser Ala Pro Leu Cys Cys Thr Leu Cys His Glu Arg
            500                 505                 510         
Leu Glu Asp Thr His Phe Val Gln Cys Pro Ser Val Pro Ser His Lys
        515                 520                 525             
Phe Cys Phe Pro Cys Ser Arg Gln Ser Ile Lys Gln Gln Gly Ala Ser
    530                 535                 540                 
Gly Glu Val Tyr Cys Pro Ser Gly Glu Lys Cys Pro Leu Val Gly Ser
545                 550                 555                 560 
Asn Val Pro Trp Ala Phe Met Gln Gly Glu Ile Ala Thr Ile Leu Ala
                565                 570                 575     
Gly Asp Val Lys Val Lys Lys Glu Arg Asp Ser
            580                 585         


<210> 8844
<211> 189
<212> PRT
<213> Homo sapiens

<400> 8844
Met Trp Arg Ala Trp Cys Leu Gly Val Arg Pro Ser Cys Cys Arg Ala
 1               5                  10                  15      
Ser Ser Pro Ala Arg Ser Thr Ala Thr Arg Thr Ala Ala Ala Pro Gly
            20                  25                  30          
Tyr Asp Val Pro His Pro Gly Arg Ala Ser Ala Leu Tyr Ser Cys Gln
        35                  40                  45              
Ala His Leu Pro Gly Arg Ser Pro Pro Gln Ala Phe Arg Ala Ala Arg
    50                  55                  60                  
Ser His Leu Leu Glu Trp Thr Lys Arg Thr Leu Ala Trp Glu Gln Val
65                  70                  75                  80  
Leu Pro Lys His Pro Ala Ala Gly Cys Gln Ala Gly Pro Leu Glu Gly
                85                  90                  95      
Lys Gly Gln Asp Ser Ser Gly Pro Pro Trp Thr Pro Ala Gly Gln Ala
            100                 105                 110         
Ala Trp Ala Arg Ala Gln Ala Phe Gly Ser Ala Ala Pro Lys Gly Thr
        115                 120                 125             
Gly Ser Leu Leu Gly Leu Phe Pro Ser Trp Thr Arg Pro Pro Ala Phe
    130                 135                 140                 
Ala Ser His Lys Leu Tyr Ser Ile Phe Ile Lys Ser Leu Phe His Asn
145                 150                 155                 160 
Phe Pro Ser Ile Val Leu Pro Asn Glu Asn Gly Gly Thr Pro Asn His
                165                 170                 175     
Arg Pro Thr Gly Arg Gly Asn Asn Ile Ser Ser His His
            180                 185                 


<210> 8845
<211> 193
<212> PRT
<213> Homo sapiens

<400> 8845
Met Glu Pro Leu Ala Ser Asn Ile Gln Val Leu Leu Gln Ala Ala Glu
 1               5                  10                  15      
Phe Leu Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Leu
            20                  25                  30          
Cys Pro His Arg Ser Pro Gly Pro Ile His Arg Arg Lys Lys Arg Pro
        35                  40                  45              
Pro Gln Ala Pro Gly Ala Gln Asp Ser Gly Arg Ser Val His Asn Glu
    50                  55                  60                  
Leu Glu Lys Arg Arg Arg Ala Gln Leu Lys Arg Cys Leu Glu Arg Leu
65                  70                  75                  80  
Lys Gln Gln Met Pro Leu Gly Ala Asp Cys Ala Arg Tyr Thr Thr Leu
                85                  90                  95      
Ser Leu Leu Arg Arg Ala Arg Met His Ile Gln Lys Leu Glu Asp Gln
            100                 105                 110         
Glu Gln Arg Ala Arg Gln Leu Lys Glu Arg Leu Arg Ser Lys Gln Gln
        115                 120                 125             
Ser Leu Gln Arg Gln Leu Glu Gln Leu Arg Gly Leu Ala Gly Ala Ala
    130                 135                 140                 
Glu Arg Glu Arg Leu Arg Ala Asp Ser Leu Asp Ser Ser Gly Leu Ser
145                 150                 155                 160 
Ser Glu Arg Ser Asp Ser Asp Gln Val Leu Pro Asn Glu Asn Gly Gly
                165                 170                 175     
Thr Pro Asn His Arg Pro Thr Gly Arg Gly Asn Asn Ile Ser Ser His
            180                 185                 190         
His
    


<210> 8846
<211> 459
<212> PRT
<213> Homo sapiens

<400> 8846
Met Asp Glu Lys Ser Asn Lys Leu Leu Leu Ala Leu Val Met Leu Phe
 1               5                  10                  15      
Leu Phe Ala Val Ile Val Leu Gln Tyr Val Cys Pro Gly Thr Glu Cys
            20                  25                  30          
Gln Leu Leu Arg Leu Gln Ala Phe Ser Ser Pro Val Pro Asp Pro Tyr
        35                  40                  45              
Arg Ser Glu Asp Glu Ser Ser Ala Arg Phe Val Pro Arg Tyr Asn Phe
    50                  55                  60                  
Thr Arg Gly Asp Leu Leu Arg Lys Val Asp Phe Asp Ile Lys Gly Asp
65                  70                  75                  80  
Asp Leu Ile Val Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr Phe
                85                  90                  95      
Gly Arg His Leu Val Arg Asn Ile Gln Leu Glu Gln Pro Cys Glu Cys
            100                 105                 110         
Arg Val Gly Gln Lys Lys Cys Thr Cys His Arg Pro Gly Lys Arg Glu
        115                 120                 125             
Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu His
    130                 135                 140                 
Ala Asp Trp Thr Glu Leu Thr Ser Cys Val Pro Ser Val Val Asp Gly
145                 150                 155                 160 
Lys Arg Asp Ala Arg Leu Arg Pro Ser Arg Asn Phe His Tyr Ile Thr
                165                 170                 175     
Ile Leu Arg Asp Pro Val Ser Arg Tyr Leu Ser Glu Trp Arg His Val
            180                 185                 190         
Gln Arg Gly Ala Thr Trp Lys Ala Ser Leu His Val Cys Asp Gly Arg
        195                 200                 205             
Pro Pro Thr Ser Glu Glu Leu Pro Ser Cys Tyr Thr Gly Asp Asp Trp
    210                 215                 220                 
Ser Gly Cys Pro Leu Lys Glu Phe Met Asp Cys Pro Tyr Asn Leu Ala
225                 230                 235                 240 
Asn Asn Arg Gln Val Arg Met Leu Ser Asp Leu Thr Leu Val Gly Cys
                245                 250                 255     
Tyr Asn Leu Ser Val Met Pro Glu Lys Gln Arg Asn Lys Val Leu Leu
            260                 265                 270         
Glu Ser Ala Lys Ser Asn Leu Lys His Met Ala Phe Phe Gly Leu Thr
        275                 280                 285             
Glu Phe Gln Arg Lys Thr Gln Tyr Leu Phe Glu Lys Thr Phe Asn Met
    290                 295                 300                 
Asn Phe Ile Ser Pro Phe Thr Gln Tyr Asn Thr Thr Arg Ala Ser Ser
305                 310                 315                 320 
Val Glu Ile Asn Glu Glu Ile Gln Lys Arg Ile Glu Gly Leu Asn Phe
                325                 330                 335     
Leu Asp Met Glu Leu Tyr Ser Tyr Ala Lys Asp Leu Phe Leu Gln Arg
            340                 345                 350         
Tyr Gln Phe Met Arg Gln Lys Glu His Gln Glu Ala Arg Arg Lys Arg
        355                 360                 365             
Gln Glu Gln Arg Lys Phe Leu Lys Gly Arg Leu Leu Gln Thr His Phe
    370                 375                 380                 
Gln Ser Gln Gly Gln Gly Gln Ser Gln Asn Pro Asn Gln Asn Gln Ser
385                 390                 395                 400 
Gln Asn Pro Asn Pro Asn Ala Asn Gln Asn Leu Thr Gln Asn Leu Met
                405                 410                 415     
Gln Asn Leu Thr Gln Ser Leu Ser Gln Lys Glu Asn Arg Glu Ser Pro
            420                 425                 430         
Lys Gln Asn Ser Gly Lys Glu Gln Asn Asp Asn Thr Ser Asn Gly Thr
        435                 440                 445             
Asn Asp Tyr Ile Gly Ser Val Glu Lys Trp Arg
    450                 455                 


<210> 8847
<211> 1507
<212> PRT
<213> Homo sapiens

<400> 8847
Ala Ala Ala Ser Arg Cys Pro Gly Ile Met Val Ala Leu Arg Gly Leu
 1               5                  10                  15      
Gly Ser Gly Leu Gln Pro Trp Cys Pro Leu Asp Leu Arg Leu Glu Trp
            20                  25                  30          
Val Asp Thr Val Trp Glu Leu Asp Phe Thr Glu Thr Glu Pro Leu Asp
        35                  40                  45              
Pro Ser Ile Glu Ala Glu Ile Ile Glu Thr Gly Leu Ala Ala Phe Thr
    50                  55                  60                  
Lys Leu Tyr Glu Ser Leu Leu Pro Phe Ala Thr Gly Glu His Gly Ser
65                  70                  75                  80  
Met Glu Ser Ile Trp Thr Phe Phe Ile Glu Asn Asn Val Ser His Ser
                85                  90                  95      
Thr Leu Val Ala Leu Phe Tyr His Phe Val Gln Ile Val His Lys Lys
            100                 105                 110         
Asn Val Ser Val Gln Tyr Arg Glu Tyr Gly Leu His Ala Ala Gly Leu
        115                 120                 125             
Tyr Phe Leu Leu Leu Glu Val Pro Gly Ser Val Ala Asn Gln Val Phe
    130                 135                 140                 
His Pro Val Met Phe Asp Lys Cys Ile Gln Thr Leu Lys Lys Ser Trp
145                 150                 155                 160 
Pro Gln Glu Ser Asn Leu Asn Arg Lys Arg Lys Lys Glu Gln Pro Lys
                165                 170                 175     
Ser Ser Gln Ala Asn Pro Gly Arg His Arg Lys Arg Gly Lys Pro Pro
            180                 185                 190         
Arg Arg Glu Asp Ile Glu Met Asp Glu Ile Ile Glu Glu Gln Glu Asp
        195                 200                 205             
Glu Asn Ile Cys Phe Ser Ala Arg Asp Leu Ser Gln Ile Arg Asn Ala
    210                 215                 220                 
Ile Phe His Leu Leu Lys Asn Phe Leu Arg Leu Leu Pro Lys Phe Ser
225                 230                 235                 240 
Leu Lys Glu Lys Pro Gln Cys Val Gln Asn Cys Ile Glu Val Phe Val
                245                 250                 255     
Ser Leu Thr Asn Phe Glu Pro Val Leu His Glu Cys His Val Thr Gln
            260                 265                 270         
Ala Arg Ala Leu Asn Gln Ala Lys Tyr Ile Pro Glu Leu Ala Tyr Tyr
        275                 280                 285             
Gly Leu Tyr Leu Leu Cys Ser Pro Ile His Gly Glu Gly Asp Lys Val
    290                 295                 300                 
Ile Ser Cys Val Phe His Gln Met Leu Ser Val Ile Leu Met Leu Glu
305                 310                 315                 320 
Val Gly Glu Gly Ser His Arg Ala Pro Leu Ala Val Thr Ser Gln Val
                325                 330                 335     
Ile Asn Cys Arg Asn Gln Ala Val Gln Phe Ile Ser Ala Leu Val Asp
            340                 345                 350         
Glu Leu Lys Glu Ser Ile Phe Pro Val Val Arg Ile Leu Leu Gln His
        355                 360                 365             
Ile Cys Ala Lys Val Val Asp Lys Ser Glu Tyr Arg Thr Phe Ala Ala
    370                 375                 380                 
Gln Ser Leu Val Gln Leu Leu Ser Lys Leu Pro Cys Gly Glu Tyr Ala
385                 390                 395                 400 
Met Phe Ile Ala Trp Leu Tyr Lys Tyr Ser Arg Ser Ser Lys Ile Pro
                405                 410                 415     
His Arg Val Phe Thr Leu Asp Val Val Leu Ala Leu Leu Glu Leu Pro
            420                 425                 430         
Glu Arg Glu Val Asp Asn Thr Leu Ser Leu Glu His Gln Lys Phe Leu
        435                 440                 445             
Lys His Lys Phe Leu Val Gln Glu Ile Met Phe Asp Arg Cys Leu Asp
    450                 455                 460                 
Lys Ala Pro Thr Val Arg Ser Lys Ala Leu Ser Ser Phe Ala His Cys
465                 470                 475                 480 
Leu Glu Leu Thr Val Thr Ser Ala Ser Glu Ser Ile Leu Glu Leu Leu
                485                 490                 495     
Ile Asn Ser Pro Thr Phe Ser Val Ile Glu Ser His Pro Gly Thr Leu
            500                 505                 510         
Leu Arg Asn Ser Ser Ala Phe Ser Tyr Gln Arg Gln Thr Ser Asn Arg
        515                 520                 525             
Ser Glu Pro Ser Gly Glu Ile Asn Ile Asp Ser Ser Gly Glu Thr Val
    530                 535                 540                 
Gly Ser Gly Glu Arg Cys Val Met Ala Met Leu Arg Arg Arg Ile Arg
545                 550                 555                 560 
Asp Glu Lys Thr Asn Val Arg Lys Ser Ala Leu Gln Val Leu Val Ser
                565                 570                 575     
Ile Leu Lys His Cys Asp Val Ser Gly Met Lys Glu Asp Leu Trp Ile
            580                 585                 590         
Leu Gln Asp Gln Cys Arg Asp Pro Ala Val Ser Val Arg Lys Gln Ala
        595                 600                 605             
Leu Gln Ser Leu Thr Glu Leu Leu Met Ala Gln Pro Arg Cys Val Gln
    610                 615                 620                 
Ile Gln Lys Ala Trp Leu Arg Gly Val Val Pro Val Val Met Asp Cys
625                 630                 635                 640 
Glu Ser Thr Val Gln Glu Lys Ala Leu Glu Phe Leu Asp Gln Leu Leu
                645                 650                 655     
Leu Gln Asn Ile Arg His His Ser His Phe His Ser Gly Asp Asp Ser
            660                 665                 670         
Gln Val Leu Ala Trp Ala Leu Leu Thr Leu Leu Thr Thr Glu Ser Gln
        675                 680                 685             
Glu Leu Ser Arg Tyr Leu Asn Lys Ala Phe His Ile Trp Ser Lys Lys
    690                 695                 700                 
Glu Lys Phe Ser Pro Thr Phe Ile Asn Asn Val Ile Ser His Thr Gly
705                 710                 715                 720 
Thr Glu His Ser Ala Pro Ala Trp Met Leu Leu Ser Lys Ile Ala Gly
                725                 730                 735     
Ser Ser Pro Arg Leu Asp Tyr Ser Arg Ile Ile Gln Ser Trp Glu Lys
            740                 745                 750         
Ile Ser Ser Gln Gln Asn Pro Asn Ser Asn Thr Leu Gly His Ile Leu
        755                 760                 765             
Cys Val Ile Gly His Ile Ala Lys His Leu Pro Lys Ser Thr Arg Asp
    770                 775                 780                 
Lys Val Thr Asp Ala Val Lys Cys Lys Leu Asn Gly Phe Gln Trp Ser
785                 790                 795                 800 
Leu Glu Val Ile Ser Ser Ala Val Asp Ala Leu Gln Arg Leu Cys Arg
                805                 810                 815     
Ala Ser Ala Glu Thr Pro Ala Glu Glu Gln Glu Leu Leu Thr Gln Val
            820                 825                 830         
Cys Gly Asp Val Leu Ser Thr Cys Glu His Arg Leu Ser Asn Ile Val
        835                 840                 845             
Leu Lys Glu Asn Gly Thr Gly Asn Met Asp Glu Asp Leu Leu Val Lys
    850                 855                 860                 
Tyr Ile Phe Thr Leu Gly Asp Ile Ala Gln Leu Cys Pro Ala Arg Val
865                 870                 875                 880 
Glu Lys Arg Ile Phe Leu Leu Ile Gln Ser Val Leu Ala Ser Ser Ala
                885                 890                 895     
Asp Ala Asp His Ser Pro Ser Ser Gln Gly Ser Ser Glu Ala Pro Ala
            900                 905                 910         
Ser Gln Pro Pro Pro Gln Val Arg Gly Ser Val Met Pro Ser Val Ile
        915                 920                 925             
Arg Ala His Ala Ile Ile Thr Leu Gly Lys Leu Cys Leu Gln His Glu
    930                 935                 940                 
Asp Leu Ala Lys Lys Ser Ile Pro Ala Leu Val Arg Glu Leu Glu Val
945                 950                 955                 960 
Cys Glu Asp Val Ala Val Arg Asn Asn Val Ile Ile Val Met Cys Asp
                965                 970                 975     
Leu Cys Ile Arg Tyr Thr Ile Met Val Asp Lys Tyr Ile Pro Asn Ile
            980                 985                 990         
Ser Met Cys Leu Lys Asp Ser Asp Pro Phe Ile Arg Lys Gln Thr Leu
        995                 1000                1005            
Ile Leu Leu Thr Asn Leu Leu Gln Glu Glu Phe Val Lys Trp Lys Gly
    1010                1015                1020                
Ser Leu Phe Phe Arg Phe Val Ser Thr Leu Ile Asp Ser His Pro Asp
1025                1030                1035                1040
Ile Ala Ser Phe Gly Glu Phe Cys Leu Ala His Leu Leu Leu Lys Arg
                1045                1050                1055    
Asn Pro Val Met Phe Phe Gln His Phe Ile Glu Cys Ile Phe His Phe
            1060                1065                1070        
Asn Asn Tyr Glu Lys His Glu Lys Tyr Asn Lys Phe Pro Gln Ser Glu
        1075                1080                1085            
Arg Glu Lys Arg Leu Phe Ser Leu Lys Gly Lys Ser Asn Lys Glu Arg
    1090                1095                1100                
Arg Met Lys Ile Tyr Lys Phe Leu Leu Glu His Phe Thr Asp Glu Gln
1105                1110                1115                1120
Arg Phe Asn Ile Thr Ser Lys Ile Cys Leu Ser Ile Leu Ala Cys Phe
                1125                1130                1135    
Ala Asp Gly Ile Leu Pro Leu Asp Leu Asp Ala Ser Glu Leu Leu Ser
            1140                1145                1150        
Asp Thr Phe Glu Val Leu Ser Ser Lys Glu Ile Lys Leu Leu Ala Met
        1155                1160                1165            
Arg Ser Lys Pro Asp Lys Asp Leu Leu Met Glu Glu Asp Asp Met Ala
    1170                1175                1180                
Leu Ala Asn Val Val Met Gln Glu Ala Gln Lys Lys Leu Ile Ser Gln
1185                1190                1195                1200
Val Gln Lys Arg Asn Phe Ile Glu Asn Ile Ile Pro Ile Ile Ile Ser
                1205                1210                1215    
Leu Lys Thr Val Leu Glu Lys Asn Lys Ile Pro Ala Leu Arg Glu Leu
            1220                1225                1230        
Met His Tyr Leu Arg Glu Val Met Gln Asp Tyr Arg Asp Glu Leu Lys
        1235                1240                1245            
Asp Phe Phe Ala Val Asp Lys Gln Leu Ala Ser Glu Leu Glu Tyr Asp
    1250                1255                1260                
Met Lys Lys Tyr Gln Glu Gln Leu Val Gln Glu Gln Glu Leu Ala Lys
1265                1270                1275                1280
His Ala Asp Val Ala Gly Thr Ala Gly Gly Ala Glu Val Ala Pro Val
                1285                1290                1295    
Ala Gln Val Ala Leu Cys Leu Glu Thr Val Pro Val Pro Ala Gly Gln
            1300                1305                1310        
Glu Asn Pro Ala Met Ser Pro Ala Val Ser Gln Pro Cys Thr Pro Arg
        1315                1320                1325            
Ala Ser Ala Gly His Val Ala Val Ser Ser Pro Thr Pro Glu Thr Gly
    1330                1335                1340                
Pro Leu Gln Arg Leu Leu Pro Lys Ala Arg Pro Met Ser Leu Ser Thr
1345                1350                1355                1360
Ile Ala Ile Leu Asn Ser Val Lys Lys Ala Val Glu Ser Lys Ser Arg
                1365                1370                1375    
His Arg Ser Arg Ser Leu Gly Val Leu Pro Phe Thr Leu Asn Ser Gly
            1380                1385                1390        
Ser Pro Glu Lys Thr Cys Ser Gln Val Ser Ser Tyr Ser Leu Glu Gln
        1395                1400                1405            
Glu Ser Asn Gly Glu Ile Glu His Val Thr Lys Arg Ala Ile Ser Thr
    1410                1415                1420                
Pro Glu Lys Ser Ile Ser Asp Val Thr Phe Gly Ala Gly Val Ser Tyr
1425                1430                1435                1440
Ile Gly Thr Pro Arg Thr Pro Ser Ser Ala Lys Glu Lys Ile Glu Gly
                1445                1450                1455    
Arg Ser Gln Gly Asn Asp Ile Leu Cys Leu Ser Leu Pro Asp Lys Pro
            1460                1465                1470        
Pro Pro Gln Pro Gln Gln Trp Asn Val Arg Ser Pro Ala Arg Asn Lys
        1475                1480                1485            
Asp Thr Pro Ala Cys Ser Arg Arg Ser Leu Arg Lys Thr Pro Leu Lys
    1490                1495                1500                
Thr Ala Asn
1505        


<210> 8848
<211> 309
<212> PRT
<213> Homo sapiens

<400> 8848
Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln
 1               5                  10                  15      
Pro Gln Trp Ile Gln Val Arg Asn Met Ala Thr Leu Lys Asp Ile Thr
            20                  25                  30          
Arg Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Thr Lys Ser Met
        35                  40                  45              
Lys Met Val Ala Ala Ala Lys Tyr Ala Arg Ala Glu Arg Glu Leu Lys
    50                  55                  60                  
Pro Ala Arg Ile Tyr Gly Leu Gly Ser Leu Ala Leu Tyr Glu Lys Ala
65                  70                  75                  80  
Asp Ile Lys Gly Pro Glu Asp Lys Lys Lys His Leu Leu Ile Gly Val
                85                  90                  95      
Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys
            100                 105                 110         
Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val
        115                 120                 125             
Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Ile Leu Tyr Arg Thr
    130                 135                 140                 
His Ser Asp Gln Phe Leu Val Ala Phe Lys Glu Val Gly Arg Lys Pro
145                 150                 155                 160 
Pro Thr Phe Gly Asp Ala Ser Val Ile Ala Leu Glu Leu Leu Asn Ser
                165                 170                 175     
Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Lys Phe Arg Gln
            180                 185                 190         
Asp Arg Phe Arg Asn Gln Ser Phe Phe Met Ser Val Ile Ser Tyr Lys
        195                 200                 205             
Thr Glu Glu Lys Pro Ile Phe Ser Leu Asn Thr Val Ala Ser Ala Asp
    210                 215                 220                 
Ser Met Ser Ile Tyr Asp Asp Ile Asp Ala Asp Val Leu Gln Asn Tyr
225                 230                 235                 240 
Gln Glu Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr Ser Leu Lys Glu Ser
                245                 250                 255     
Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala Met Asp Asn Ala Ser
            260                 265                 270         
Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr Leu Thr Phe Asn Arg
        275                 280                 285             
Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile Glu Ile Ile Ser Gly
    290                 295                 300                 
Ala Ala Ala Leu Asp
305                 


<210> 8849
<211> 308
<212> PRT
<213> Homo sapiens

<400> 8849
Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln
 1               5                  10                  15      
Pro Gln Trp Ile Gln Val Arg Asn Met Ala Thr Leu Lys Asp Ile Thr
            20                  25                  30          
Arg Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Thr Lys Ser Met
        35                  40                  45              
Lys Met Val Ala Ala Ala Lys Tyr Ala Arg Ala Glu Arg Glu Leu Lys
    50                  55                  60                  
Pro Ala Arg Ile Tyr Gly Leu Gly Ser Leu Ala Leu Tyr Glu Lys Ala
65                  70                  75                  80  
Asp Ile Lys Gly Pro Glu Asp Lys Lys Lys His Leu Leu Ile Gly Val
                85                  90                  95      
Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys
            100                 105                 110         
Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val
        115                 120                 125             
Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Ile Leu Tyr Arg Thr
    130                 135                 140                 
His Ser Asp Gln Phe Leu Val Ala Phe Lys Glu Val Gly Arg Lys Pro
145                 150                 155                 160 
Pro Thr Phe Gly Asp Ala Ser Val Ile Ala Leu Glu Leu Leu Asn Ser
                165                 170                 175     
Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Lys Phe Arg Gln
            180                 185                 190         
Asp Arg Phe Arg Asn Gln Ser Phe Phe Met Ser Val Ile Ser Tyr Lys
        195                 200                 205             
Thr Glu Glu Lys Pro Ile Phe Ser Leu Asn Thr Val Ala Ser Ala Asp
    210                 215                 220                 
Ser Met Ser Ile Tyr Asp Asp Ile Asp Ala Asp Val Leu Gln Asn Tyr
225                 230                 235                 240 
Gln Glu Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr Ser Leu Lys Glu Ser
                245                 250                 255     
Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala Met Asp Asn Ala Ser
            260                 265                 270         
Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr Leu Thr Phe Asn Arg
        275                 280                 285             
Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile Glu Ile Ile Ser Gly
    290                 295                 300                 
Ala Ala Ala Leu
305             


<210> 8850
<211> 349
<212> PRT
<213> Homo sapiens

<400> 8850
Met His Arg Asn Phe Arg Lys Trp Ile Phe Tyr Val Phe Leu Cys Phe
 1               5                  10                  15      
Gly Val Leu Tyr Val Lys Leu Gly Ala Leu Ser Ser Val Val Ala Leu
            20                  25                  30          
Gly Ala Asn Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln
        35                  40                  45              
Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu
    50                  55                  60                  
Gly Ala Gln Met Gly Ile Asn Glu Cys Gln Tyr Gln Phe Arg Phe Gly
65                  70                  75                  80  
Arg Trp Asn Cys Ser Ala Leu Gly Glu Lys Thr Val Phe Gly Gln Glu
                85                  90                  95      
Leu Arg Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Thr Ala
            100                 105                 110         
Ala Gly Val Ala His Ala Val Thr Ala Ala Cys Ser Gln Gly Asn Leu
        115                 120                 125             
Ser Asn Cys Gly Cys Asp Arg Glu Lys Gln Gly Tyr Tyr Asn Gln Ala
    130                 135                 140                 
Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Val Arg Tyr Gly Ile
145                 150                 155                 160 
Asp Phe Ser Arg Arg Phe Val Asp Ala Arg Glu Ile Lys Lys Asn Ala
                165                 170                 175     
Arg Arg Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Val Leu
            180                 185                 190         
Glu Asp Arg Met Gln Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser
        195                 200                 205             
Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Lys Phe Arg Glu Val
    210                 215                 220                 
Gly His Leu Leu Lys Glu Lys Tyr Asn Ala Ala Val Gln Val Glu Val
225                 230                 235                 240 
Val Arg Ala Ser Arg Leu Arg Gln Pro Thr Phe Leu Arg Ile Lys Gln
                245                 250                 255     
Leu Arg Ser Tyr Gln Lys Pro Met Glu Thr Asp Leu Val Tyr Ile Glu
            260                 265                 270         
Lys Ser Pro Asn Tyr Cys Glu Glu Asp Ala Ala Thr Gly Ser Val Gly
        275                 280                 285             
Thr Gln Gly Arg Leu Cys Asn Arg Thr Ser Pro Gly Ala Asp Gly Cys
    290                 295                 300                 
Asp Thr Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Thr Lys
305                 310                 315                 320 
Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Phe Val Lys Cys
                325                 330                 335     
Asn Thr Cys Ser Glu Arg Thr Glu Val Phe Thr Cys Lys
            340                 345                 


<210> 8851
<211> 455
<212> PRT
<213> Homo sapiens

<400> 8851
Met Trp Leu Glu Ile Leu Leu Thr Ser Val Leu Gly Phe Ala Ile Tyr
 1               5                  10                  15      
Trp Phe Ile Ser Arg Asp Lys Glu Glu Thr Leu Pro Leu Glu Asp Gly
            20                  25                  30          
Trp Trp Gly Pro Gly Thr Arg Ser Ala Ala Arg Glu Asp Asp Ser Ile
        35                  40                  45              
Arg Pro Phe Lys Val Glu Thr Ser Asp Glu Glu Ile His Asp Leu His
    50                  55                  60                  
Gln Arg Ile Asp Lys Phe Arg Phe Thr Pro Pro Leu Glu Asp Ser Cys
65                  70                  75                  80  
Phe His Tyr Gly Phe Asn Ser Asn Tyr Leu Lys Lys Val Ile Ser Tyr
                85                  90                  95      
Trp Arg Asn Glu Phe Asp Trp Lys Lys Gln Val Glu Ile Leu Asn Arg
            100                 105                 110         
Tyr Pro His Phe Lys Thr Lys Ile Glu Gly Leu Asp Ile His Phe Ile
        115                 120                 125             
His Val Lys Pro Pro Gln Leu Pro Ala Gly His Thr Pro Lys Pro Leu
    130                 135                 140                 
Leu Met Val His Gly Trp Pro Gly Ser Phe Tyr Glu Phe Tyr Lys Ile
145                 150                 155                 160 
Ile Pro Leu Leu Thr Asp Pro Lys Asn His Gly Leu Ser Asp Glu His
                165                 170                 175     
Val Phe Glu Val Ile Cys Pro Ser Ile Pro Gly Tyr Gly Phe Ser Glu
            180                 185                 190         
Ala Ser Ser Lys Lys Gly Phe Asn Ser Val Ala Thr Ala Arg Ile Phe
        195                 200                 205             
Tyr Lys Leu Met Leu Arg Leu Gly Phe Gln Glu Phe Tyr Ile Gln Gly
    210                 215                 220                 
Gly Asp Trp Gly Ser Leu Ile Cys Thr Asn Met Ala Gln Leu Val Pro
225                 230                 235                 240 
Ser His Val Lys Gly Leu His Leu Asn Met Ala Leu Val Leu Ser Asn
                245                 250                 255     
Phe Ser Thr Leu Thr Leu Leu Leu Gly Gln Arg Phe Gly Arg Phe Leu
            260                 265                 270         
Gly Leu Thr Glu Arg Asp Val Glu Leu Leu Tyr Pro Val Lys Glu Lys
        275                 280                 285             
Val Phe Tyr Ser Leu Met Arg Glu Ser Gly Tyr Met His Ile Gln Cys
    290                 295                 300                 
Thr Lys Pro Asp Thr Val Gly Ser Ala Leu Asn Asp Ser Pro Val Gly
305                 310                 315                 320 
Leu Ala Ala Tyr Ile Leu Glu Lys Phe Ser Thr Trp Thr Asn Thr Glu
                325                 330                 335     
Phe Arg Tyr Leu Glu Asp Gly Gly Leu Glu Arg Lys Phe Ser Leu Asp
            340                 345                 350         
Asp Leu Leu Thr Asn Val Met Leu Tyr Trp Thr Thr Gly Thr Ile Ile
        355                 360                 365             
Ser Ser Gln Arg Phe Tyr Lys Glu Asn Leu Gly Gln Gly Trp Met Thr
    370                 375                 380                 
Gln Lys His Glu Arg Met Lys Val Tyr Val Pro Thr Gly Phe Ser Ala
385                 390                 395                 400 
Phe Pro Phe Glu Leu Leu His Thr Pro Glu Lys Trp Val Arg Phe Lys
                405                 410                 415     
Tyr Pro Lys Leu Ile Ser Tyr Ser Tyr Met Val Arg Gly Gly His Phe
            420                 425                 430         
Ala Ala Phe Glu Glu Pro Glu Leu Leu Ala Gln Asp Ile Arg Lys Phe
        435                 440                 445             
Leu Ser Val Leu Glu Arg Gln
    450                 455 


<210> 8852
<211> 603
<212> PRT
<213> Homo sapiens

<400> 8852
Met Ala Val Ala Arg Lys Ile Arg Thr Leu Leu Thr Val Asn Ile Leu
 1               5                  10                  15      
Val Phe Val Gly Ile Val Leu Phe Ser Val Tyr Cys Arg Leu Gln Gly
            20                  25                  30          
Arg Ser Gln Glu Leu Val Arg Ile Val Ser Gly Asp Arg Arg Val Arg
        35                  40                  45              
Ser Arg His Ala Lys Val Gly Thr Leu Gly Asp Arg Glu Ala Ile Leu
    50                  55                  60                  
Gln Arg Leu Asp His Leu Glu Glu Val Val Tyr Asn Gln Leu Asn Gly
65                  70                  75                  80  
Leu Ala Lys Pro Ile Gly Leu Val Glu Gly Pro Gly Gly Leu Gly Gln
                85                  90                  95      
Gly Gly Leu Ala Ala Thr Leu Arg Asp Asp Gly Gln Glu Ala Glu Gly
            100                 105                 110         
Lys Tyr Glu Glu Tyr Gly Tyr Asn Ala Gln Leu Ser Asp Arg Ile Ser
        115                 120                 125             
Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Arg Lys Cys Arg Gln Met
    130                 135                 140                 
Ser Tyr Ala Gln Asp Leu Pro Gln Val Ser Val Val Phe Ile Phe Val
145                 150                 155                 160 
Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Val Val Asn
                165                 170                 175     
His Thr Pro Ser Gln Leu Leu Lys Glu Val Ile Leu Val Asp Asp Asn
            180                 185                 190         
Ser Asp Asn Val Glu Leu Lys Phe Asn Leu Asp Gln Tyr Val Asn Lys
        195                 200                 205             
Arg Tyr Pro Gly Leu Val Lys Ile Val Arg Asn Ser Arg Arg Glu Gly
    210                 215                 220                 
Leu Ile Arg Ala Arg Leu Gln Gly Trp Lys Ala Ala Thr Ala Pro Val
225                 230                 235                 240 
Val Gly Phe Phe Asp Ala His Val Glu Phe Asn Thr Gly Trp Ala Glu
                245                 250                 255     
Pro Ala Leu Ser Arg Ile Arg Glu Asp Arg Arg Arg Ile Val Leu Pro
            260                 265                 270         
Ala Ile Asp Asn Ile Lys Tyr Ser Thr Phe Glu Val Gln Gln Tyr Ala
        275                 280                 285             
Asn Ala Ala His Gly Tyr Asn Trp Gly Leu Arg Cys Met Tyr Ile Ile
    290                 295                 300                 
Pro Pro Gln Asp Trp Leu Asp Arg Gly Asp Glu Ser Ala Pro Ile Arg
305                 310                 315                 320 
Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asp Arg Glu Tyr Phe
                325                 330                 335     
Gly Asp Ile Gly Leu Leu Asp Pro Gly Met Glu Val Tyr Gly Gly Glu
            340                 345                 350         
Asn Val Glu Leu Gly Met Arg Val Trp Gln Cys Gly Gly Ser Met Glu
        355                 360                 365             
Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Thr Arg Lys Pro
    370                 375                 380                 
Tyr Asn Asn Asp Ile Asp Tyr Tyr Ala Lys Arg Asn Ala Leu Arg Ala
385                 390                 395                 400 
Ala Glu Val Trp Met Asp Asp Phe Lys Ser His Val Tyr Met Ala Trp
                405                 410                 415     
Asn Ile Pro Met Ser Asn Pro Gly Val Asp Phe Gly Asp Val Ser Glu
            420                 425                 430         
Arg Leu Ala Leu Arg Gln Arg Leu Lys Cys Arg Ser Phe Lys Trp Tyr
        435                 440                 445             
Leu Glu Asn Val Tyr Pro Glu Met Arg Val Tyr Asn Asn Thr Leu Thr
    450                 455                 460                 
Tyr Gly Glu Val Arg Asn Ser Lys Ala Ser Ala Tyr Cys Leu Asp Gln
465                 470                 475                 480 
Gly Ala Glu Asp Gly Asp Arg Ala Ile Leu Tyr Pro Cys His Gly Met
                485                 490                 495     
Ser Ser Gln Leu Val Arg Tyr Ser Ala Asp Gly Leu Leu Gln Leu Gly
            500                 505                 510         
Pro Leu Gly Ser Thr Ala Phe Leu Pro Asp Ser Lys Cys Leu Val Asp
        515                 520                 525             
Asp Gly Thr Gly Arg Met Pro Thr Leu Lys Arg Cys Glu Asp Val Ala
    530                 535                 540                 
Arg Pro Thr Gln Arg Leu Trp Asp Phe Thr Gln Ser Gly Pro Ile Val
545                 550                 555                 560 
Ser Arg Ala Thr Gly Arg Cys Leu Glu Val Glu Met Ser Lys Asp Ala
                565                 570                 575     
Asn Phe Gly Leu Arg Leu Val Val Gln Arg Cys Ser Gly Gln Lys Trp
            580                 585                 590         
Met Ile Arg Asn Trp Ile Lys His Ala Arg His
        595                 600             


<210> 8853
<211> 752
<212> PRT
<213> Homo sapiens

<400> 8853
Met Ser Ser Ala Phe Gly Ala Phe Tyr Ala Met Ser Leu Ser Leu Trp
 1               5                  10                  15      
Lys Ile Pro Asn Leu Lys Pro Ile Ala Met Phe Trp Gln Leu Gln Ala
            20                  25                  30          
Cys Ile Leu Lys Ile Ser Phe Gly Ala Ile Gln Ser Val Phe Pro Ala
        35                  40                  45              
Thr Ser Trp Ser Trp Thr Ile Ser Lys Leu Lys Cys Leu Leu Lys Tyr
    50                  55                  60                  
Leu Ile Ile Ser Thr Val Pro Gln Ser Leu Ser Arg Asp Arg Lys Gln
65                  70                  75                  80  
Ser Leu Ile Ser Gln Leu Gln Glu Lys Ser Trp Glu Tyr Arg Ser Trp
                85                  90                  95      
Lys Thr Leu Leu Ile Ala Thr Ser Gln Ile Pro Arg Val Pro Met Tyr
            100                 105                 110         
Ser Val Leu Leu Lys Arg Glu Trp Leu Lys Lys Lys Lys Asn Glu Lys
        115                 120                 125             
Arg His Glu Glu Pro Ala Ile Thr Asn Gly Pro Arg Ile Thr Asn Ala
    130                 135                 140                 
Phe Ser Ile Ile Glu Thr Glu Asn Ser Asn Asn Met Phe Ser Pro Leu
145                 150                 155                 160 
Asp Leu Arg Ala Ser Phe Lys Lys Val Ser Asp Ser Met Arg Thr Ala
                165                 170                 175     
Ser Leu Cys Leu Glu Arg Thr Asp Val Cys His Glu Ala Glu Pro Val
            180                 185                 190         
Arg Thr Leu Ala Glu His Ser Tyr Ala Val Ser Ser Val Ala Glu Ala
        195                 200                 205             
Tyr Arg Ser Gln Pro Val Arg Glu His Asp Gly Ser Ser Pro Gly Asn
    210                 215                 220                 
Thr Gly Lys Glu Asn Cys Glu Ala Leu Ala Ala Lys Pro Lys Thr Cys
225                 230                 235                 240 
Arg Lys Pro Lys Thr Phe Ser Ile Pro Gln Asp Ser Asp Ser Ala Thr
                245                 250                 255     
Glu Asn Ile Pro Pro Pro Pro Val Ser Asn Leu Glu Val Asn Gln Glu
            260                 265                 270         
Arg Ser Pro Gln Pro Ala Ala Val Leu Thr Arg Ser Lys Ser Pro Asn
        275                 280                 285             
Asn Glu Gly Asp Val His Phe Ser Arg Glu Asp Glu Asn Gln Ser Ser
    290                 295                 300                 
Asp Val Pro Gly Pro Pro Ala Ala Glu Val Pro Pro Leu Val Tyr Asn
305                 310                 315                 320 
Cys Ser Cys Cys Ser Lys Ala Phe Asp Ser Ser Thr Leu Leu Ser Ala
                325                 330                 335     
His Met Gln Leu His Lys Pro Thr Gln Glu Pro Leu Val Cys Lys Tyr
            340                 345                 350         
Cys Asn Lys Gln Phe Thr Thr Leu Asn Arg Leu Asp Arg His Glu Gln
        355                 360                 365             
Ile Cys Met Arg Ser Ser His Met Pro Ile Pro Gly Gly Asn Gln Arg
    370                 375                 380                 
Phe Leu Glu Asn Tyr Pro Thr Ile Gly Gln Asn Gly Gly Ser Phe Thr
385                 390                 395                 400 
Gly Pro Glu Pro Leu Leu Ser Glu Asn Arg Ile Gly Glu Phe Ser Ser
                405                 410                 415     
Thr Gly Ser Thr Leu Pro Asp Thr Asp His Met Val Lys Phe Val Asn
            420                 425                 430         
Gly Gln Met Leu Tyr Ser Cys Val Val Cys Lys Arg Ser Tyr Val Thr
        435                 440                 445             
Leu Ser Ser Leu Arg Arg His Ala Asn Val His Ser Trp Arg Arg Thr
    450                 455                 460                 
Tyr Pro Cys His Tyr Cys Asn Lys Val Phe Ala Leu Ala Glu Tyr Arg
465                 470                 475                 480 
Thr Arg His Glu Ile Trp His Thr Gly Glu Arg Arg Tyr Gln Cys Ile
                485                 490                 495     
Phe Cys Leu Glu Thr Phe Met Thr Tyr Tyr Ile Leu Lys Asn His Gln
            500                 505                 510         
Lys Ser Phe His Ala Ile Asp His Arg Leu Ser Ile Ser Lys Lys Thr
        515                 520                 525             
Ala Asn Gly Gly Leu Lys Pro Ser Val Tyr Pro Tyr Lys Leu Tyr Arg
    530                 535                 540                 
Leu Leu Pro Met Lys Cys Lys Arg Ala Pro Tyr Lys Ser Tyr Arg Asn
545                 550                 555                 560 
Ser Ser Tyr Glu Asn Ala Arg Glu Asn Ser Gln Met Asn Glu Ser Ala
                565                 570                 575     
Pro Gly Thr Tyr Val Val Gln Asn Pro His Ser Ser Glu Leu Pro Thr
            580                 585                 590         
Leu Asn Phe Gln Asp Thr Val Asn Thr Leu Thr Asn Ser Pro Ala Ile
        595                 600                 605             
Pro Leu Glu Thr Ser Ala Cys Gln Asp Ile Pro Thr Ser Ala Asn Val
    610                 615                 620                 
Gln Asn Ala Glu Gly Thr Lys Trp Gly Glu Glu Ala Leu Lys Met Asp
625                 630                 635                 640 
Leu Asp Asn Asn Phe Tyr Ser Thr Glu Val Ser Val Ser Ser Thr Glu
                645                 650                 655     
Asn Ala Val Ser Ser Asp Leu Arg Ala Gly Asp Val Pro Val Leu Ser
            660                 665                 670         
Leu Ser Asn Ser Ser Glu Asn Ala Ala Ser Val Ile Ser Tyr Ser Gly
        675                 680                 685             
Ser Ala Pro Ser Val Ile Val His Ser Ser Gln Phe Ser Ser Val Ile
    690                 695                 700                 
Met His Ser Asn Ala Ile Ala Ala Met Thr Ser Ser Asn His Arg Ala
705                 710                 715                 720 
Phe Ser Asp Pro Ala Val Ser Gln Ser Leu Lys Asp Asp Ser Lys Pro
                725                 730                 735     
Glu Pro Asp Lys Val Gly Arg Phe Ala Ser Arg Pro Lys Ser Ile Lys
            740                 745                 750         


<210> 8854
<211> 176
<212> PRT
<213> Homo sapiens

<400> 8854
Met Ser Gly Ile Ser Gly Cys Pro Phe Phe Leu Trp Gly Leu Leu Ala
 1               5                  10                  15      
Leu Leu Gly Leu Ala Leu Val Ile Ser Leu Ile Phe Asn Ile Ser His
            20                  25                  30          
Tyr Val Glu Lys Gln Arg Gln Asp Lys Met Tyr Ser Tyr Ser Ser Asp
        35                  40                  45              
His Thr Arg Val Asp Glu Tyr Tyr Ile Glu Asp Thr Pro Ile Tyr Gly
    50                  55                  60                  
Asn Leu Asp Asp Met Ile Ser Glu Pro Met Asp Glu Asn Cys Tyr Glu
65                  70                  75                  80  
Gln Met Lys Ala Arg Pro Glu Lys Ser Val Asn Lys Met Gln Glu Ala
                85                  90                  95      
Thr Pro Ser Ala Gln Ala Thr Asn Glu Thr Gln Met Cys Tyr Ala Ser
            100                 105                 110         
Leu Asp His Ser Val Lys Gly Lys Arg Arg Lys Pro Arg Lys Gln Asn
        115                 120                 125             
Thr His Phe Ser Asp Lys Asp Gly Asp Glu Gln Leu His Ala Ile Asp
    130                 135                 140                 
Ala Ser Val Ser Lys Thr Thr Leu Val Asp Ser Phe Ser Pro Glu Ser
145                 150                 155                 160 
Gln Ala Val Glu Glu Thr Phe Met Met Ile Pro Ser Asp Cys Leu Asp
                165                 170                 175     


<210> 8855
<211> 712
<212> PRT
<213> Homo sapiens

<400> 8855
Thr Gly Asn Lys Met Ala Ala Ala Gly Pro Ser Thr Arg Ala Ser Ser
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Leu Ser Arg Arg Gly Arg Arg Gly Arg Cys
            20                  25                  30          
Asp Glu Thr Ala Ala Ala Lys Thr Gly Ala Pro Gly Pro Ala Ser Gly
        35                  40                  45              
Pro Ser Leu Leu Val Leu Ser Pro Pro Leu Leu Gln Pro Pro Leu Pro
    50                  55                  60                  
Pro Arg Pro Glu Glu Ser Gly Cys Ala Gly Cys Leu Glu Pro Pro Gly
65                  70                  75                  80  
Glu Ala Ala Ala Leu Pro Cys Gly His Ser Leu Cys Arg Gly Cys Ala
                85                  90                  95      
Gln Arg Ala Ala Asp Ala Ala Gly Pro Gly Cys Pro Arg Cys Arg Ala
            100                 105                 110         
Arg Gly Pro Gly Trp Ala Arg Arg Arg Ala Arg Asp Asp Gly Gln Ala
        115                 120                 125             
Asp Ser Glu Val Leu Gly Glu Cys Ala Arg Arg Ser Gln Pro Glu Arg
    130                 135                 140                 
Cys Arg Pro Arg Arg Asp Gly Gly Ala Ala Ala Ala Gly Pro Arg Pro
145                 150                 155                 160 
Glu Gln Glu Pro Arg Ala Ala Pro Ala Glu Pro Asp Phe Ile Phe Arg
                165                 170                 175     
Ala Pro Ile Lys Leu Ser Lys Pro Gly Glu Leu Arg Glu Glu Tyr Glu
            180                 185                 190         
Ser Leu Arg Lys Leu Arg Glu Glu Lys Leu Gln Glu Glu Lys Pro Ser
        195                 200                 205             
Glu Asp Gln Ile His Lys Leu Leu Pro Glu Asp Thr Glu Thr Gly Lys
    210                 215                 220                 
Arg Lys Met Asp Glu Gln Lys Lys Arg Asp Glu Pro Leu Val Leu Lys
225                 230                 235                 240 
Thr Asn Leu Glu Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu
                245                 250                 255     
Glu Pro Ser Arg Gly Gln Met Thr Gln Thr His Arg Ser Ala Phe Val
            260                 265                 270         
Ser Lys Asn Asn Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn
        275                 280                 285             
Ser Lys Val Glu Arg Ser Gln Ser Cys Ser Asp Thr Ala Gln Glu Arg
    290                 295                 300                 
Ala Lys Ser Arg Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val Thr
305                 310                 315                 320 
Thr Met Thr Pro Ala Ser Asn Pro Ile Ile Gly Val Leu Leu Ser Thr
                325                 330                 335     
Gln Asn Asn Arg Cys Val Ser Ala Pro Asp Leu Thr Ile Glu Lys Arg
            340                 345                 350         
Leu Pro Phe Ser Ser Leu Ser Ser Leu Ala Ser Leu His Lys Pro Glu
        355                 360                 365             
Arg Ser Val Ser Pro Glu Ser Asn Asp Ser Ile Ser Glu Glu Leu Asn
    370                 375                 380                 
His Phe Lys Pro Ile Val Cys Ser Pro Cys Thr Pro Pro Lys Arg Leu
385                 390                 395                 400 
Pro Asp Gly Arg Val Leu Ser Pro Leu Ile Ile Lys Ser Thr Pro Arg
                405                 410                 415     
Asn Leu Asn Arg Ser Leu Gln Lys Gln Thr Ser Tyr Glu Ala Ser Pro
            420                 425                 430         
Arg Ile Leu Lys Lys Trp Glu Gln Ile Phe Gln Glu Arg Gln Ile Lys
        435                 440                 445             
Lys Thr Leu Ser Lys Ala Thr Leu Thr Ser Leu Ala Pro Glu Met Gly
    450                 455                 460                 
Glu Glu Leu Leu Gly Ser Glu Gly Ile His Ser Ser Lys Glu Lys Pro
465                 470                 475                 480 
Leu Val Ala Val Asn Thr Arg Leu Ser Gly Gly Gln Val Leu Ser Glu
                485                 490                 495     
Tyr Thr Gly Pro Thr Ser Ala Asp Leu Asp His Phe Pro Ser Val Ser
            500                 505                 510         
Gln Thr Lys Ala Glu Gln Asp Ser Asp Asn Lys Ser Ser Thr Glu Ile
        515                 520                 525             
Pro Leu Glu Thr Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly Ser Gly
    530                 535                 540                 
Thr Ser Leu Glu Arg Glu Gln Phe Glu Gly Leu Gly Ser Thr Pro Asp
545                 550                 555                 560 
Ala Lys Leu Asp Lys Thr Cys Ile Ser Arg Ala Met Lys Ile Thr Thr
                565                 570                 575     
Val Asn Ser Val Leu Pro Gln Asn Ser Val Leu Gly Gly Val Leu Lys
            580                 585                 590         
Thr Lys Gln Gln Leu Lys Thr Leu Asn His Phe Asp Leu Thr Asn Gly
        595                 600                 605             
Val Leu Val Glu Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu Arg Arg
    610                 615                 620                 
Gly Arg Lys Arg His Cys Lys Thr Lys His Leu Glu Gln Asn Gly Ser
625                 630                 635                 640 
Leu Lys Lys Leu Arg Gln Thr Ser Gly Glu Val Gly Leu Ala Pro Thr
                645                 650                 655     
Asp Pro Val Leu Arg Glu Met Glu Gln Lys Leu Gln Gln Glu Glu Glu
            660                 665                 670         
Asp Arg Gln Leu Ala Leu Gln Leu Gln Arg Met Phe Asp Asn Glu Arg
        675                 680                 685             
Arg Thr Val Ser Arg Arg Lys Gly Ser Val Asp Gln Tyr Leu Leu Arg
    690                 695                 700                 
Ser Ser Asn Met Ala Gly Ala Lys
705                 710         


<210> 8856
<211> 3054
<212> PRT
<213> Homo sapiens

<400> 8856
Met Trp Ala Leu Ser Pro Thr Val Phe Ala Leu Leu Ser Lys Asn Leu
 1               5                  10                  15      
Met Ile Val His Ser Asp Leu Ala Val His Phe Pro Ala Ile Gln Tyr
            20                  25                  30          
Ala Val Leu Tyr Thr Leu Tyr Ser His Cys Thr Arg His Asp His Phe
        35                  40                  45              
Ile Ser Ser Ser Leu Ser Ser Ser Ser Pro Ser Leu Phe Asp Gly Ala
    50                  55                  60                  
Val Ile Ser Thr Val Thr Thr Ala Thr Lys Lys His Phe Ser Ile Ile
65                  70                  75                  80  
Leu Asn Leu Leu Gly Ile Leu Leu Lys Lys Asp Asn Leu Asn Gln Asp
                85                  90                  95      
Thr Arg Lys Leu Leu Met Thr Trp Ala Leu Glu Ala Ala Val Leu Met
            100                 105                 110         
Lys Lys Ser Glu Thr Tyr Ala Pro Leu Phe Ser Leu Pro Ser Phe His
        115                 120                 125             
Lys Phe Cys Lys Gly Leu Leu Ala Asn Thr Leu Val Glu Asp Val Asn
    130                 135                 140                 
Ile Cys Leu Gln Ala Cys Ser Ser Leu His Ala Leu Ser Ser Ser Leu
145                 150                 155                 160 
Pro Asp Asp Leu Leu Gln Arg Cys Val Asp Val Cys Arg Val Gln Leu
                165                 170                 175     
Val His Ser Gly Thr Arg Ile Arg Gln Ala Phe Gly Lys Leu Leu Lys
            180                 185                 190         
Ser Ile Pro Leu Asp Val Val Leu Ser Asn Asn Asn His Thr Glu Ile
        195                 200                 205             
Gln Glu Ile Ser Leu Ala Leu Arg Ser His Met Ser Lys Ala Pro Ser
    210                 215                 220                 
Asn Thr Phe His Pro Gln Asp Phe Ser Asp Val Ile Ser Phe Ile Leu
225                 230                 235                 240 
Tyr Gly Asn Ser His Arg Thr Gly Lys Asp Asn Trp Leu Glu Arg Leu
                245                 250                 255     
Phe Tyr Ser Cys Gln Arg Leu Asp Lys Arg Asp Gln Ser Thr Ile Pro
            260                 265                 270         
Arg Asn Leu Leu Lys Thr Asp Ala Val Leu Trp Gln Trp Ala Ile Trp
        275                 280                 285             
Glu Ala Ala Gln Phe Thr Val Leu Ser Lys Leu Arg Thr Pro Leu Gly
    290                 295                 300                 
Arg Ala Gln Asp Thr Phe Gln Thr Ile Glu Gly Ile Ile Arg Ser Leu
305                 310                 315                 320 
Ala Ala His Thr Leu Asn Pro Asp Gln Asp Val Ser Gln Trp Thr Thr
                325                 330                 335     
Ala Asp Asn Asp Glu Gly His Gly Asn Asn Gln Leu Arg Leu Val Leu
            340                 345                 350         
Leu Leu Gln Tyr Leu Glu Asn Leu Glu Lys Leu Met Tyr Asn Ala Tyr
        355                 360                 365             
Glu Gly Cys Ala Asn Ala Leu Thr Ser Pro Pro Lys Val Ile Arg Thr
    370                 375                 380                 
Phe Phe Tyr Thr Asn Arg Gln Thr Cys Gln Asp Trp Leu Thr Arg Ile
385                 390                 395                 400 
Arg Leu Ser Ile Met Arg Val Gly Leu Leu Ala Gly Gln Pro Ala Val
                405                 410                 415     
Thr Val Arg His Gly Phe Asp Leu Leu Thr Glu Met Lys Thr Thr Ser
            420                 425                 430         
Leu Ser Gln Gly Asn Glu Leu Glu Val Thr Ile Met Met Val Val Glu
        435                 440                 445             
Ala Leu Cys Glu Leu His Cys Pro Glu Ala Ile Gln Gly Ile Ala Val
    450                 455                 460                 
Trp Ser Ser Ser Ile Val Gly Lys Asn Leu Leu Trp Ile Asn Ser Val
465                 470                 475                 480 
Ala Gln Gln Ala Glu Gly Arg Phe Glu Lys Ala Ser Val Glu Tyr Gln
                485                 490                 495     
Glu His Leu Cys Ala Met Thr Gly Val Asp Cys Cys Ile Ser Ser Phe
            500                 505                 510         
Asp Lys Ser Val Leu Thr Leu Ala Asn Ala Gly Arg Asn Ser Ala Ser
        515                 520                 525             
Pro Lys His Ser Leu Asn Gly Glu Ser Arg Lys Thr Val Leu Ser Lys
    530                 535                 540                 
Pro Thr Asp Ser Ser Pro Glu Val Ile Asn Tyr Leu Gly Asn Lys Ala
545                 550                 555                 560 
Cys Glu Cys Tyr Ile Ser Ile Ala Asp Trp Ala Ala Val Gln Glu Trp
                565                 570                 575     
Gln Asn Ala Ile His Asp Leu Lys Lys Ser Thr Ser Ser Thr Ser Leu
            580                 585                 590         
Asn Leu Lys Ala Asp Phe Asn Tyr Ile Lys Ser Leu Ser Ser Phe Glu
        595                 600                 605             
Ser Gly Lys Phe Val Glu Cys Thr Glu Gln Leu Glu Leu Leu Pro Gly
    610                 615                 620                 
Glu Asn Ile Asn Leu Leu Ala Gly Gly Ser Lys Glu Lys Ile Asp Met
625                 630                 635                 640 
Lys Lys Leu Leu Pro Asn Met Leu Ser Pro Asp Pro Arg Glu Leu Gln
                645                 650                 655     
Lys Ser Ile Glu Val Gln Leu Leu Arg Ser Ser Val Cys Leu Ala Thr
            660                 665                 670         
Ala Leu Asn Pro Ile Glu Gln Asp Gln Lys Trp Gln Ser Ile Thr Glu
        675                 680                 685             
Asn Val Val Lys Tyr Leu Lys Gln Thr Ser Arg Ile Ala Ile Gly Pro
    690                 695                 700                 
Leu Arg Leu Ser Thr Leu Thr Val Ser Gln Ser Leu Pro Val Leu Ser
705                 710                 715                 720 
Thr Leu Gln Leu Tyr Cys Ser Ser Ala Leu Glu Asn Thr Val Ser Asn
                725                 730                 735     
Arg Leu Ser Thr Glu Asp Cys Leu Ile Pro Leu Phe Ser Glu Ala Leu
            740                 745                 750         
Arg Ser Cys Lys Gln His Asp Val Arg Pro Trp Met Gln Ala Leu Arg
        755                 760                 765             
Tyr Thr Met Tyr Gln Asn Gln Leu Leu Glu Lys Ile Lys Glu Gln Thr
    770                 775                 780                 
Val Pro Ile Arg Ser His Leu Met Glu Leu Gly Leu Thr Ala Ala Lys
785                 790                 795                 800 
Phe Ala Arg Lys Arg Gly Asn Val Ser Leu Ala Thr Arg Leu Leu Ala
                805                 810                 815     
Gln Cys Ser Glu Val Gln Leu Gly Lys Thr Thr Thr Ala Gln Asp Leu
            820                 825                 830         
Val Gln His Phe Lys Lys Leu Ser Thr Gln Gly Gln Val Asp Glu Lys
        835                 840                 845             
Trp Gly Pro Glu Leu Asp Ile Glu Lys Thr Lys Leu Leu Tyr Thr Ala
    850                 855                 860                 
Gly Gln Ser Thr His Ala Met Glu Met Leu Ser Ser Cys Ala Ile Ser
865                 870                 875                 880 
Phe Cys Lys Ser Val Lys Ala Glu Tyr Ala Val Ala Lys Ser Ile Leu
                885                 890                 895     
Thr Leu Ala Lys Trp Ile Gln Ala Glu Trp Lys Glu Ile Ser Gly Gln
            900                 905                 910         
Leu Lys Gln Val Tyr Arg Ala Gln His Gln Gln Asn Phe Thr Gly Leu
        915                 920                 925             
Ser Thr Leu Ser Lys Asn Ile Leu Thr Leu Ile Glu Leu Pro Ser Val
    930                 935                 940                 
Asn Thr Met Glu Glu Glu Tyr Pro Arg Ile Glu Ser Glu Ser Thr Val
945                 950                 955                 960 
His Ile Gly Val Gly Glu Pro Asp Phe Ile Leu Gly Gln Leu Tyr His
                965                 970                 975     
Leu Ser Ser Val Gln Ala Pro Glu Val Ala Lys Ser Trp Ala Ala Leu
            980                 985                 990         
Ala Ser Trp Ala Tyr Arg Trp Gly Arg Lys Val Val Asp Asn Ala Ser
        995                 1000                1005            
Gln Gly Glu Gly Val Arg Leu Leu Pro Arg Glu Lys Ser Glu Val Gln
    1010                1015                1020                
Asn Leu Leu Pro Asp Thr Ile Thr Glu Glu Glu Lys Glu Arg Ile Tyr
1025                1030                1035                1040
Gly Ile Leu Gly Gln Ala Val Cys Arg Pro Ala Gly Ile Gln Ala Arg
                1045                1050                1055    
Lys Thr Cys Ile Leu Cys Thr Ile Phe Leu Gln Asp Glu Asp Ile Thr
            1060                1065                1070        
Leu Gln Ile Thr Glu Ser Glu Asp Asn Glu Glu Asp Asp Met Val Asp
        1075                1080                1085            
Val Ile Trp Arg Gln Leu Ile Ser Ser Cys Pro Trp Leu Ser Glu Leu
    1090                1095                1100                
Asp Glu Ser Ala Thr Glu Gly Val Ile Lys Val Trp Arg Lys Val Val
1105                1110                1115                1120
Asp Arg Ile Phe Ser Leu Tyr Lys Leu Ser Cys Ser Ala Tyr Phe Thr
                1125                1130                1135    
Phe Leu Lys Leu Asn Ala Gly Gln Ile Pro Leu Asp Glu Asp Asp Pro
            1140                1145                1150        
Arg Leu His Leu Ser His Arg Val Glu Gln Ser Thr Asp Asp Met Ile
        1155                1160                1165            
Val Met Ala Thr Leu Arg Leu Leu Arg Leu Leu Val Lys His Ala Gly
    1170                1175                1180                
Glu Leu Arg Gln Tyr Leu Glu His Gly Leu Glu Thr Thr Pro Thr Ala
1185                1190                1195                1200
Pro Trp Arg Gly Ile Ile Pro Gln Leu Phe Ser Arg Leu Asn His Pro
                1205                1210                1215    
Glu Val Tyr Val Arg Gln Ser Ile Cys Asn Leu Leu Cys Arg Val Ala
            1220                1225                1230        
Gln Asp Ser Pro His Leu Ile Leu Tyr Pro Ala Ile Val Gly Thr Ile
        1235                1240                1245            
Ser Leu Ser Ser Glu Ser Gln Ala Ser Gly Asn Lys Phe Ser Thr Ala
    1250                1255                1260                
Ile Pro Thr Leu Leu Gly Asn Ile Gln Gly Glu Glu Leu Leu Val Ser
1265                1270                1275                1280
Glu Cys Glu Gly Gly Ser Pro Pro Ala Ser Gln Asp Ser Asn Lys Asp
                1285                1290                1295    
Glu Pro Lys Ser Gly Leu Asn Glu Asp Gln Ala Met Met Gln Asp Cys
            1300                1305                1310        
Tyr Ser Lys Ile Val Asp Lys Leu Ser Ser Ala Asn Pro Thr Met Val
        1315                1320                1325            
Leu Gln Val Gln Met Leu Val Ala Glu Leu Arg Arg Val Thr Val Leu
    1330                1335                1340                
Trp Asp Glu Leu Trp Leu Gly Val Leu Leu Gln Gln His Met Tyr Val
1345                1350                1355                1360
Leu Arg Arg Ile Gln Gln Leu Glu Asp Glu Val Lys Arg Val Gln Asn
                1365                1370                1375    
Asn Asn Thr Leu Arg Lys Glu Glu Lys Ile Ala Ile Met Arg Glu Lys
            1380                1385                1390        
His Thr Ala Leu Met Lys Pro Ile Val Phe Ala Leu Glu His Val Arg
        1395                1400                1405            
Ser Ile Thr Ala Ala Pro Ala Glu Thr Pro His Glu Lys Trp Phe Gln
    1410                1415                1420                
Asp Asn Tyr Gly Asp Ala Ile Glu Asn Ala Leu Glu Lys Leu Lys Thr
1425                1430                1435                1440
Pro Leu Asn Pro Ala Lys Pro Gly Ser Ser Trp Ile Pro Phe Lys Glu
                1445                1450                1455    
Ile Met Leu Ser Leu Gln Gln Arg Ala Gln Lys Arg Ala Ser Tyr Ile
            1460                1465                1470        
Leu Arg Leu Glu Glu Ile Ser Pro Trp Leu Ala Ala Met Thr Asn Thr
        1475                1480                1485            
Glu Ile Ala Leu Pro Gly Glu Val Ser Ala Arg Asp Thr Val Thr Ile
    1490                1495                1500                
His Ser Val Gly Gly Thr Ile Thr Ile Leu Pro Thr Lys Thr Lys Pro
1505                1510                1515                1520
Lys Lys Leu Leu Phe Leu Gly Ser Asp Gly Lys Ser Tyr Pro Tyr Leu
                1525                1530                1535    
Phe Lys Gly Leu Glu Asp Leu His Leu Asp Glu Arg Ile Met Gln Phe
            1540                1545                1550        
Leu Ser Ile Val Asn Thr Met Phe Ala Thr Ile Asn Arg Gln Glu Thr
        1555                1560                1565            
Pro Arg Phe His Ala Arg His Tyr Ser Val Thr Pro Leu Gly Thr Arg
    1570                1575                1580                
Ser Gly Leu Ile Gln Trp Val Asp Gly Ala Thr Pro Leu Phe Gly Leu
1585                1590                1595                1600
Tyr Lys Arg Trp Gln Gln Arg Glu Ala Ala Leu Gln Ala Gln Lys Ala
                1605                1610                1615    
Gln Asp Ser Tyr Gln Thr Pro Gln Asn Pro Gly Ile Val Pro Arg Pro
            1620                1625                1630        
Ser Glu Leu Tyr Tyr Ser Lys Ile Gly Pro Ala Leu Lys Thr Val Gly
        1635                1640                1645            
Leu Ser Leu Asp Val Ser Arg Arg Asp Trp Pro Leu His Val Met Lys
    1650                1655                1660                
Ala Val Leu Glu Glu Leu Met Glu Ala Thr Pro Pro Asn Leu Leu Ala
1665                1670                1675                1680
Lys Glu Leu Trp Ser Ser Cys Thr Thr Pro Asp Glu Trp Trp Arg Val
                1685                1690                1695    
Thr Gln Ser Tyr Ala Arg Ser Thr Ala Val Met Ser Met Val Gly Tyr
            1700                1705                1710        
Ile Ile Gly Leu Gly Asp Arg His Leu Asp Asn Val Leu Ile Asp Met
        1715                1720                1725            
Thr Thr Gly Glu Val Val His Ile Asp Tyr Asn Val Cys Phe Glu Lys
    1730                1735                1740                
Gly Lys Ser Leu Arg Val Pro Glu Lys Val Pro Phe Arg Met Thr Gln
1745                1750                1755                1760
Asn Ile Glu Thr Ala Leu Gly Val Thr Gly Val Glu Gly Val Phe Arg
                1765                1770                1775    
Leu Ser Cys Glu Gln Val Leu His Ile Met Arg Arg Gly Arg Glu Thr
            1780                1785                1790        
Leu Leu Thr Leu Leu Glu Ala Phe Val Tyr Asp Pro Leu Val Asp Trp
        1795                1800                1805            
Thr Ala Gly Gly Glu Ala Gly Phe Ala Gly Ala Val Tyr Gly Gly Gly
    1810                1815                1820                
Gly Gln Gln Ala Glu Ser Lys Gln Ser Lys Arg Glu Met Glu Arg Glu
1825                1830                1835                1840
Ile Thr Arg Ser Leu Phe Ser Ser Arg Val Ala Glu Ile Lys Val Asn
                1845                1850                1855    
Trp Phe Lys Asn Arg Asp Glu Met Leu Val Val Leu Pro Lys Leu Asp
            1860                1865                1870        
Gly Ser Leu Asp Glu Tyr Leu Ser Leu Gln Glu Gln Leu Thr Asp Val
        1875                1880                1885            
Glu Lys Leu Gln Gly Lys Leu Leu Glu Glu Ile Glu Phe Leu Glu Gly
    1890                1895                1900                
Ala Glu Gly Val Asp His Pro Ser His Thr Leu Gln His Arg Tyr Ser
1905                1910                1915                1920
Glu His Thr Gln Leu Gln Thr Gln Gln Arg Ala Val Gln Glu Ala Ile
                1925                1930                1935    
Gln Val Lys Leu Asn Glu Phe Glu Gln Trp Ile Thr His Tyr Gln Ala
            1940                1945                1950        
Ala Phe Asn Asn Leu Glu Ala Thr Gln Leu Ala Ser Leu Leu Gln Glu
        1955                1960                1965            
Ile Ser Thr Gln Met Asp Leu Gly Pro Pro Ser Tyr Val Pro Ala Thr
    1970                1975                1980                
Ala Phe Leu Gln Asn Ala Gly Gln Ala His Leu Ile Ser Gln Cys Glu
1985                1990                1995                2000
Gln Leu Glu Gly Glu Val Gly Ala Leu Leu Gln Gln Arg Arg Ser Val
                2005                2010                2015    
Leu Arg Gly Cys Leu Glu Gln Leu His His Tyr Ala Thr Val Ala Leu
            2020                2025                2030        
Gln Tyr Pro Lys Ala Ile Phe Gln Lys His Arg Ile Glu Gln Trp Lys
        2035                2040                2045            
Thr Trp Met Glu Glu Leu Ile Cys Asn Thr Thr Val Glu Arg Cys Gln
    2050                2055                2060                
Glu Leu Tyr Arg Lys Tyr Glu Met Gln Tyr Ala Pro Gln Pro Pro Pro
2065                2070                2075                2080
Thr Val Cys Gln Phe Ile Thr Ala Thr Glu Met Thr Leu Gln Arg Tyr
                2085                2090                2095    
Ala Ala Asp Ile Asn Ser Arg Leu Ile Arg Gln Val Glu Arg Leu Lys
            2100                2105                2110        
Gln Glu Ala Val Thr Val Pro Val Cys Glu Asp Gln Leu Lys Glu Ile
        2115                2120                2125            
Glu Arg Cys Ile Lys Val Phe Leu His Glu Asn Gly Glu Glu Gly Ser
    2130                2135                2140                
Leu Ser Leu Ala Ser Val Ile Ile Ser Ala Leu Cys Thr Leu Thr Arg
2145                2150                2155                2160
Arg Asn Leu Met Met Glu Gly Ala Ala Ser Ser Ala Gly Glu Gln Leu
                2165                2170                2175    
Val Asp Leu Thr Ser Arg Asp Gly Ala Trp Phe Leu Glu Glu Leu Cys
            2180                2185                2190        
Ser Met Ser Gly Asn Val Thr Cys Leu Val Gln Leu Leu Lys Gln Cys
        2195                2200                2205            
His Leu Val Pro Gln Asp Leu Asp Ile Pro Asn Pro Met Glu Ala Ser
    2210                2215                2220                
Glu Thr Val His Leu Ala Asn Gly Val Tyr Thr Ser Leu Gln Glu Leu
2225                2230                2235                2240
Asn Ser Asn Phe Arg Gln Ile Ile Phe Pro Glu Ala Leu Arg Cys Leu
                2245                2250                2255    
Met Lys Gly Glu Tyr Thr Leu Glu Ser Met Leu His Glu Leu Asp Gly
            2260                2265                2270        
Leu Ile Glu Gln Thr Thr Asp Gly Val Pro Leu Gln Thr Leu Val Glu
        2275                2280                2285            
Ser Leu Gln Ala Tyr Leu Arg Asn Ala Ala Met Gly Leu Glu Glu Glu
    2290                2295                2300                
Thr His Ala His Tyr Ile Asp Val Ala Arg Gln Val Asn Ala Gly Cys
2305                2310                2315                2320
Ala Val Ser Leu Leu Leu His Ala Gln Tyr Gly Glu Leu Ile Gln Pro
                2325                2330                2335    
Arg Asn Gly Ser Val Asp Glu Thr Pro Lys Met Ser Ala Gly Gln Met
            2340                2345                2350        
Leu Leu Val Ala Phe Asp Gly Met Phe Ala Gln Val Glu Thr Ala Phe
        2355                2360                2365            
Ser Leu Leu Val Glu Lys Leu Asn Lys Met Glu Ile Pro Ile Ala Trp
    2370                2375                2380                
Arg Lys Ile Asp Ile Ile Arg Glu Ala Arg Ser Thr Gln Val Asn Phe
2385                2390                2395                2400
Phe Asp Asp Asp Asn His Arg Gln Val Leu Glu Glu Ile Phe Phe Leu
                2405                2410                2415    
Lys Arg Leu Gln Thr Ile Lys Glu Phe Phe Arg Leu Cys Gly Thr Phe
            2420                2425                2430        
Ser Lys Thr Leu Ser Gly Ser Ser Ser Leu Glu Asp Gln Asn Thr Val
        2435                2440                2445            
Asn Gly Pro Val Gln Ile Val Asn Val Lys Thr Leu Phe Arg Asn Ser
    2450                2455                2460                
Cys Phe Ser Glu Asp Gln Met Ala Lys Pro Ile Lys Ala Phe Thr Ala
2465                2470                2475                2480
Asp Phe Val Arg Gln Leu Leu Ile Gly Leu Pro Asn Gln Ala Leu Gly
                2485                2490                2495    
Leu Thr Leu Cys Ser Phe Ile Ser Ala Leu Gly Val Asp Ile Ile Ala
            2500                2505                2510        
Gln Val Glu Ala Lys Asp Phe Gly Ala Glu Ser Lys Val Ser Val Asp
        2515                2520                2525            
Asp Leu Cys Lys Lys Ala Val Glu His Asn Ile Gln Ile Gly Lys Phe
    2530                2535                2540                
Ser Gln Leu Val Met Asn Arg Ala Thr Val Leu Ala Ser Ser Tyr Asp
2545                2550                2555                2560
Thr Ala Trp Lys Lys His Asp Leu Val Arg Arg Leu Glu Thr Ser Ile
                2565                2570                2575    
Ser Ser Cys Lys Thr Ser Leu Gln Arg Val Gln Leu His Ile Ala Met
            2580                2585                2590        
Phe Gln Trp Gln His Glu Asp Leu Leu Ile Asn Arg Pro Gln Ala Met
        2595                2600                2605            
Ser Val Thr Pro Pro Pro Arg Ser Ala Ile Leu Thr Ser Met Lys Lys
    2610                2615                2620                
Lys Leu His Thr Leu Ser Gln Ile Glu Thr Ser Ile Ala Thr Val Gln
2625                2630                2635                2640
Glu Lys Leu Ala Ala Leu Glu Ser Ser Ile Glu Gln Arg Leu Lys Trp
                2645                2650                2655    
Ala Gly Gly Ala Asn Pro Ala Leu Ala Pro Val Leu Gln Asp Phe Glu
            2660                2665                2670        
Ala Thr Ile Ala Glu Arg Arg Asn Leu Val Leu Lys Glu Ser Gln Arg
        2675                2680                2685            
Ala Ser Gln Val Thr Phe Leu Cys Ser Asn Ile Ile His Phe Glu Ser
    2690                2695                2700                
Leu Arg Thr Arg Thr Ala Glu Ala Leu Asn Leu Asp Ala Ala Leu Phe
2705                2710                2715                2720
Glu Leu Ile Lys Arg Cys Gln Gln Met Cys Ser Phe Ala Ser Gln Phe
                2725                2730                2735    
Asn Ser Ser Val Ser Glu Leu Glu Leu Arg Leu Leu Gln Arg Val Asp
            2740                2745                2750        
Thr Gly Leu Glu His Pro Ile Gly Ser Ser Glu Trp Leu Leu Ser Ala
        2755                2760                2765            
His Lys Gln Leu Thr Gln Asp Met Ser Thr Gln Arg Ala Ile Gln Thr
    2770                2775                2780                
Glu Lys Glu Gln Gln Ile Glu Thr Val Cys Glu Thr Ile Gln Asn Leu
2785                2790                2795                2800
Val Asp Asn Ile Lys Thr Val Leu Thr Gly His Asn Arg Gln Leu Gly
                2805                2810                2815    
Asp Val Lys His Leu Leu Lys Ala Met Ala Lys Asp Glu Glu Ala Ala
            2820                2825                2830        
Leu Ala Asp Gly Glu Asp Val Pro Tyr Glu Asn Ser Val Arg Gln Phe
        2835                2840                2845            
Leu Gly Glu Tyr Lys Ser Trp Gln Asp Asn Ile Gln Thr Val Leu Phe
    2850                2855                2860                
Thr Leu Val Gln Ala Met Gly Gln Val Arg Ser Gln Glu His Val Glu
2865                2870                2875                2880
Met Leu Gln Glu Ile Thr Pro Thr Leu Lys Glu Leu Lys Thr Gln Ser
                2885                2890                2895    
Gln Ser Ile Tyr Asn Asn Leu Val Ser Phe Ala Ser Pro Leu Val Thr
            2900                2905                2910        
Asp Ala Thr Asn Glu Cys Ser Ser Pro Thr Ser Ser Ala Thr Tyr Gln
        2915                2920                2925            
Pro Ser Phe Ala Ala Ala Val Arg Ser Asn Thr Gly Gln Lys Thr Gln
    2930                2935                2940                
Pro Asp Val Met Ser Gln Asn Ala Arg Lys Leu Ile Gln Lys Asn Leu
2945                2950                2955                2960
Ala Thr Ser Ala Asp Thr Pro Pro Ser Thr Val Pro Gly Thr Gly Lys
                2965                2970                2975    
Ser Val Ala Cys Ser Pro Lys Lys Ala Val Arg Asp Pro Lys Thr Gly
            2980                2985                2990        
Lys Ala Val Gln Glu Arg Asn Ser Tyr Ala Val Ser Val Trp Lys Arg
        2995                3000                3005            
Val Lys Ala Lys Leu Glu Gly Arg Asp Val Asp Pro Asn Arg Arg Met
    3010                3015                3020                
Ser Val Ala Glu Gln Val Asp Tyr Val Ile Lys Glu Ala Thr Asn Leu
3025                3030                3035                3040
Asp Asn Leu Ala Gln Leu Tyr Glu Gly Trp Thr Ala Trp Val
                3045                3050                


<210> 8857
<211> 3657
<212> PRT
<213> Homo sapiens

<400> 8857
Met Ser Arg Arg Ala Pro Gly Ser Arg Leu Ser Ser Gly Gly Thr Asn
 1               5                  10                  15      
Tyr Ser Arg Ser Trp Asn Asp Trp Gln Pro Arg Thr Asp Ser Ala Ser
            20                  25                  30          
Ala Asp Pro Gly Asn Leu Lys Tyr Ser Ser Ser Arg Asp Arg Gly Gly
        35                  40                  45              
Ser Ser Ser Tyr Gly Leu Gln Pro Ser Asn Ser Ala Val Val Ser Arg
    50                  55                  60                  
Gln Arg His Asp Asp Thr Arg Val His Ala Asp Ile Gln Asn Asp Glu
65                  70                  75                  80  
Lys Gly Gly Tyr Ser Val Asn Gly Gly Ser Gly Glu Asn Thr Tyr Gly
                85                  90                  95      
Arg Lys Ser Leu Gly Gln Glu Leu Arg Val Asn Asn Val Thr Ser Pro
            100                 105                 110         
Glu Phe Thr Ser Val Gln His Gly Ser Arg Ala Leu Ala Thr Lys Asp
        115                 120                 125             
Met Arg Lys Ser Gln Glu Arg Ser Met Ser Tyr Ser Asp Glu Ser Arg
    130                 135                 140                 
Leu Ser Asn Leu Leu Arg Arg Ile Thr Arg Glu Asp Asp Arg Asp Arg
145                 150                 155                 160 
Arg Leu Ala Thr Val Lys Gln Leu Lys Glu Phe Ile Gln Gln Pro Glu
                165                 170                 175     
Asn Lys Leu Val Leu Val Lys Gln Leu Asp Asn Ile Leu Ala Ala Val
            180                 185                 190         
His Asp Val Leu Asn Glu Ser Ser Lys Leu Leu Gln Glu Leu Arg Gln
        195                 200                 205             
Glu Gly Ala Cys Cys Leu Gly Leu Leu Cys Ala Ser Leu Ser Tyr Glu
    210                 215                 220                 
Ala Glu Lys Ile Phe Lys Trp Ile Phe Ser Lys Phe Ser Ser Ser Ala
225                 230                 235                 240 
Lys Asp Glu Val Lys Leu Leu Tyr Leu Cys Ala Thr Tyr Lys Ala Leu
                245                 250                 255     
Glu Thr Val Gly Glu Lys Lys Ala Phe Ser Ser Val Met Gln Leu Val
            260                 265                 270         
Met Thr Ser Leu Gln Ser Ile Leu Glu Asn Val Asp Thr Pro Glu Leu
        275                 280                 285             
Leu Cys Lys Cys Val Lys Cys Ile Leu Leu Val Ala Arg Cys Tyr Pro
    290                 295                 300                 
His Ile Phe Ser Thr Asn Phe Arg Asp Thr Val Asp Ile Leu Val Gly
305                 310                 315                 320 
Trp His Ile Asp His Thr Gln Lys Pro Ser Leu Thr Gln Gln Val Ser
                325                 330                 335     
Gly Trp Leu Gln Ser Leu Glu Pro Phe Trp Val Ala Asp Leu Ala Phe
            340                 345                 350         
Ser Thr Thr Leu Leu Gly Gln Phe Leu Glu Asp Met Glu Ala Tyr Ala
        355                 360                 365             
Glu Asp Leu Ser His Val Ala Ser Gly Glu Ser Val Asp Glu Asp Val
    370                 375                 380                 
Pro Pro Pro Ser Val Ser Leu Pro Lys Leu Ala Ala Leu Leu Arg Val
385                 390                 395                 400 
Phe Ser Thr Val Val Arg Ser Ile Gly Glu Arg Phe Ser Pro Ile Arg
                405                 410                 415     
Gly Pro Pro Ile Thr Glu Ala Tyr Val Thr Asp Val Leu Tyr Arg Val
            420                 425                 430         
Met Arg Cys Val Thr Ala Ala Asn Gln Val Phe Phe Ser Glu Ala Val
        435                 440                 445             
Leu Thr Ala Ala Asn Glu Cys Val Gly Val Leu Leu Gly Ser Leu Asp
    450                 455                 460                 
Pro Ser Met Thr Ile His Cys Asp Met Val Ile Thr Tyr Gly Leu Asp
465                 470                 475                 480 
Gln Leu Glu Asn Cys Gln Thr Cys Gly Thr Asp Tyr Ile Ile Ser Val
                485                 490                 495     
Leu Asn Leu Leu Thr Leu Ile Val Glu Gln Ile Asn Thr Lys Leu Pro
            500                 505                 510         
Ser Ser Phe Val Glu Lys Leu Phe Ile Pro Ser Ser Lys Leu Leu Phe
        515                 520                 525             
Leu Arg Tyr His Lys Glu Lys Glu Val Val Ala Val Ala His Ala Val
    530                 535                 540                 
Tyr Gln Ala Val Leu Ser Leu Lys Asn Ile Pro Val Leu Glu Thr Ala
545                 550                 555                 560 
Tyr Lys Leu Ile Leu Gly Glu Met Thr Cys Ala Leu Asn Asn Leu Leu
                565                 570                 575     
His Ser Leu Gln Leu Pro Glu Ala Cys Ser Glu Ile Lys His Glu Ala
            580                 585                 590         
Phe Lys Asn His Val Phe Asn Val Asp Asn Ala Lys Phe Val Val Lys
        595                 600                 605             
Phe Asp Leu Ser Ala Leu Thr Thr Ile Gly Asn Ala Lys Asn Ser Leu
    610                 615                 620                 
Ile Gly Met Trp Ala Leu Ser Pro Thr Val Phe Ala Leu Leu Ser Lys
625                 630                 635                 640 
Asn Leu Met Ile Val His Ser Asp Leu Ala Val His Phe Pro Ala Ile
                645                 650                 655     
Gln Tyr Ala Val Leu Tyr Thr Leu Tyr Ser His Cys Thr Arg His Asp
            660                 665                 670         
His Phe Ile Ser Ser Ser Leu Ser Ser Ala Ser Pro Ser Leu Phe Asp
        675                 680                 685             
Gly Ala Val Ile Ser Thr Val Thr Thr Ala Thr Lys Lys His Phe Ser
    690                 695                 700                 
Ile Ile Leu Asn Leu Leu Gly Ile Leu Leu Lys Lys Asp Asn Leu Asn
705                 710                 715                 720 
Gln Asp Thr Arg Lys Leu Leu Met Thr Trp Ala Leu Glu Ala Ala Val
                725                 730                 735     
Leu Met Arg Lys Ser Glu Thr Tyr Ala Pro Leu Phe Ser Leu Pro Ser
            740                 745                 750         
Phe His Lys Phe Cys Lys Gly Leu Leu Ala Asn Thr Leu Val Glu Asp
        755                 760                 765             
Val Asn Ile Cys Leu Gln Ala Cys Ser Ser Leu His Ala Leu Ser Ser
    770                 775                 780                 
Ser Leu Pro Asp Asp Leu Leu Gln Arg Cys Val Asp Val Cys Arg Val
785                 790                 795                 800 
Gln Leu Val His Ser Gly Thr Arg Ile Arg Gln Ala Phe Gly Lys Leu
                805                 810                 815     
Leu Lys Ser Ile Pro Leu Asp Val Val Leu Ser Asn Asn Asn His Thr
            820                 825                 830         
Glu Ile Gln Glu Ile Ser Leu Ala Leu Arg Ser His Met Ser Lys Ala
        835                 840                 845             
Pro Ser Asn Thr Phe His Pro Gln Asp Phe Ser Asp Val Ile Ser Phe
    850                 855                 860                 
Ile Leu Tyr Gly Asn Ser His Arg Thr Gly Lys Asp Asn Trp Leu Glu
865                 870                 875                 880 
Arg Leu Phe Tyr Ser Cys Gln Arg Leu Asp Lys Arg Asp Gln Ser Thr
                885                 890                 895     
Ile Pro Arg Asn Leu Leu Lys Thr Asp Ala Val Leu Trp Gln Trp Ala
            900                 905                 910         
Ile Trp Glu Ala Ala Gln Phe Thr Val Leu Ser Lys Leu Arg Thr Pro
        915                 920                 925             
Leu Gly Arg Ala Gln Asp Thr Phe Gln Thr Ile Glu Gly Ile Ile Arg
    930                 935                 940                 
Ser Leu Ala Ala His Thr Leu Asn Pro Asp Gln Asp Val Ser Gln Trp
945                 950                 955                 960 
Thr Thr Ala Asp Asn Asp Glu Gly His Gly Asn Asn Gln Leu Arg Leu
                965                 970                 975     
Val Leu Leu Leu Gln Tyr Leu Glu Asn Leu Glu Lys Leu Met Tyr Asn
            980                 985                 990         
Ala Tyr Glu Gly Cys Ala Asn Ala Leu Thr Ser Pro Pro Lys Val Ile
        995                 1000                1005            
Arg Thr Phe Phe Tyr Thr Asn Arg Gln Thr Cys Gln Asp Trp Leu Thr
    1010                1015                1020                
Arg Ile Arg Leu Ser Ile Met Arg Val Gly Leu Leu Ala Gly Gln Pro
1025                1030                1035                1040
Ala Val Thr Val Arg His Gly Phe Asp Leu Leu Thr Glu Met Lys Thr
                1045                1050                1055    
Thr Ser Leu Ser Gln Gly Asn Glu Leu Glu Val Thr Ile Met Met Val
            1060                1065                1070        
Val Glu Ala Leu Cys Glu Leu His Cys Pro Glu Ala Ile Gln Gly Ile
        1075                1080                1085            
Ala Val Trp Ser Ser Ser Ile Val Gly Lys Asn Leu Leu Trp Ile Asn
    1090                1095                1100                
Ser Val Ala Gln Gln Ala Glu Gly Arg Phe Glu Lys Ala Ser Val Glu
1105                1110                1115                1120
Tyr Gln Glu His Leu Cys Ala Met Thr Gly Val Asp Cys Cys Ile Ser
                1125                1130                1135    
Ser Phe Asp Lys Ser Val Leu Thr Leu Ala Asn Ala Gly Arg Asn Ser
            1140                1145                1150        
Ala Ser Pro Lys His Ser Leu Asn Gly Glu Ser Arg Lys Thr Val Leu
        1155                1160                1165            
Ser Lys Pro Thr Asp Ser Ser Pro Glu Val Ile Asn Tyr Leu Gly Asn
    1170                1175                1180                
Lys Ala Cys Glu Phe Tyr Ile Ser Ile Ala Asp Trp Ala Ala Val Gln
1185                1190                1195                1200
Glu Trp Gln Asn Ala Ile His Asp Leu Lys Lys Ser Thr Ser Ser Thr
                1205                1210                1215    
Ser Leu Asn Leu Lys Ala Asp Phe Asn Tyr Ile Lys Ser Leu Ser Ser
            1220                1225                1230        
Phe Glu Ser Gly Lys Phe Val Glu Cys Thr Glu Gln Leu Glu Leu Leu
        1235                1240                1245            
Pro Gly Glu Asn Ile Asn Leu Leu Ala Gly Gly Ser Lys Glu Lys Ile
    1250                1255                1260                
Asp Met Lys Lys Leu Leu Pro Asn Met Leu Ser Pro Asp Pro Arg Glu
1265                1270                1275                1280
Leu Gln Lys Ser Ile Glu Val Gln Leu Leu Arg Ser Ser Val Cys Leu
                1285                1290                1295    
Ala Thr Ala Leu Asn Pro Ile Glu Gln Asp Gln Lys Trp Gln Ser Ile
            1300                1305                1310        
Thr Glu Asn Val Val Lys Tyr Leu Lys Gln Thr Ser Arg Ile Ala Ile
        1315                1320                1325            
Gly Pro Leu Arg Leu Ser Thr Leu Thr Val Ser Gln Ser Leu Pro Val
    1330                1335                1340                
Leu Ser Thr Leu Gln Leu Tyr Cys Ser Ser Ala Leu Glu Asn Thr Val
1345                1350                1355                1360
Ser Asn Arg Leu Ser Thr Glu Asp Cys Leu Ile Pro Leu Phe Ser Glu
                1365                1370                1375    
Ala Leu Arg Ser Cys Lys Gln His Asp Val Arg Pro Trp Met Gln Ala
            1380                1385                1390        
Leu Arg Tyr Thr Met Tyr Gln Asn Gln Leu Leu Glu Lys Ile Lys Glu
        1395                1400                1405            
Gln Thr Val Pro Ile Arg Ser His Leu Met Glu Leu Gly Leu Thr Ala
    1410                1415                1420                
Ala Lys Phe Ala Arg Lys Arg Gly Asn Val Ser Leu Ala Thr Arg Leu
1425                1430                1435                1440
Leu Ala Gln Cys Ser Glu Val Gln Leu Gly Lys Thr Thr Thr Ala Gln
                1445                1450                1455    
Asp Leu Val Gln His Phe Lys Lys Leu Ser Thr Gln Gly Gln Val Asp
            1460                1465                1470        
Glu Lys Trp Gly Pro Glu Leu Asp Ile Glu Lys Thr Lys Leu Leu Tyr
        1475                1480                1485            
Thr Ala Gly Gln Ser Thr His Ala Met Glu Met Leu Ser Ser Cys Ala
    1490                1495                1500                
Ile Ser Phe Cys Lys Ser Val Lys Ala Glu Tyr Ala Val Ala Lys Ser
1505                1510                1515                1520
Ile Leu Thr Leu Ala Lys Trp Ile Gln Ala Glu Trp Lys Glu Ile Ser
                1525                1530                1535    
Gly Gln Leu Lys Gln Val Tyr Arg Ala Gln His Gln Gln Asn Phe Thr
            1540                1545                1550        
Gly Leu Ser Thr Leu Ser Lys Asn Ile Leu Thr Leu Ile Glu Leu Pro
        1555                1560                1565            
Ser Val Asn Thr Met Glu Glu Glu Tyr Pro Arg Ile Glu Ser Glu Ser
    1570                1575                1580                
Thr Val His Ile Gly Val Gly Glu Pro Asp Phe Ile Leu Gly Gln Leu
1585                1590                1595                1600
Tyr His Leu Ser Ser Val Gln Ala Pro Glu Val Ala Lys Ser Trp Ala
                1605                1610                1615    
Ala Leu Ala Ser Trp Ala Tyr Arg Trp Gly Arg Lys Val Val Asp Asn
            1620                1625                1630        
Ala Ser Gln Gly Glu Gly Val Arg Leu Leu Pro Arg Glu Lys Ser Glu
        1635                1640                1645            
Val Gln Asn Leu Leu Pro Asp Thr Ile Thr Glu Glu Glu Lys Glu Arg
    1650                1655                1660                
Ile Tyr Gly Ile Leu Gly Gln Ala Val Cys Arg Pro Ala Gly Ile Gln
1665                1670                1675                1680
Asp Glu Asp Ile Thr Leu Gln Ile Thr Glu Ser Glu Asp Asn Glu Glu
                1685                1690                1695    
Asp Asp Met Val Asp Val Ile Trp Arg Gln Leu Ile Ser Ser Cys Pro
            1700                1705                1710        
Trp Leu Ser Glu Leu Asp Glu Ser Ala Thr Glu Gly Val Ile Lys Val
        1715                1720                1725            
Trp Arg Lys Val Val Asp Arg Ile Phe Ser Leu Tyr Lys Leu Ser Cys
    1730                1735                1740                
Ser Ala Tyr Phe Thr Phe Leu Lys Leu Asn Ala Gly Gln Ile Pro Leu
1745                1750                1755                1760
Asp Glu Asp Asp Pro Arg Leu His Leu Ser His Arg Val Glu Gln Ser
                1765                1770                1775    
Thr Asp Asp Met Ile Val Met Ala Thr Leu Arg Leu Leu Arg Leu Leu
            1780                1785                1790        
Val Lys His Ala Gly Glu Leu Arg Gln Tyr Leu Glu His Gly Leu Glu
        1795                1800                1805            
Thr Thr Pro Thr Ala Pro Trp Arg Gly Ile Ile Pro Gln Leu Phe Ser
    1810                1815                1820                
Arg Leu Asn His Pro Glu Val Tyr Val Arg Gln Ser Ile Cys Asn Leu
1825                1830                1835                1840
Leu Cys Arg Val Ala Gln Asp Ser Pro His Leu Ile Leu Tyr Pro Ala
                1845                1850                1855    
Ile Val Gly Thr Ile Ser Leu Ser Ser Glu Ser Gln Ala Ser Gly Asn
            1860                1865                1870        
Lys Phe Ser Thr Ala Ile Pro Thr Leu Leu Gly Asn Ile Gln Gly Glu
        1875                1880                1885            
Glu Leu Leu Val Ser Glu Cys Glu Gly Gly Ser Pro Pro Ala Ser Gln
    1890                1895                1900                
Asp Ser Asn Lys Asp Glu Pro Lys Ser Gly Leu Asn Glu Asp Gln Ala
1905                1910                1915                1920
Met Met Gln Asp Cys Tyr Ser Lys Ile Val Asp Lys Leu Ser Ser Ala
                1925                1930                1935    
Asn Pro Thr Met Val Leu Gln Val Gln Met Leu Val Ala Glu Leu Arg
            1940                1945                1950        
Arg Val Thr Val Leu Trp Asp Glu Leu Trp Leu Gly Val Leu Leu Gln
        1955                1960                1965            
Gln His Met Tyr Val Leu Arg Arg Ile Gln Gln Leu Glu Asp Glu Val
    1970                1975                1980                
Lys Arg Val Gln Asn Asn Asn Thr Leu Arg Lys Glu Glu Lys Ile Ala
1985                1990                1995                2000
Ile Met Arg Glu Arg His Thr Ala Leu Met Lys Pro Ile Val Phe Ala
                2005                2010                2015    
Leu Glu His Val Arg Ser Ile Thr Ala Ala Pro Ala Glu Thr Pro His
            2020                2025                2030        
Glu Lys Trp Phe Gln Asp Asn Tyr Gly Asp Ala Ile Glu Asn Ala Leu
        2035                2040                2045            
Glu Lys Leu Lys Thr Pro Leu Asn Pro Ala Lys Pro Gly Ser Ser Trp
    2050                2055                2060                
Ile Pro Phe Lys Glu Ile Met Leu Ser Leu Gln Gln Arg Ala Gln Lys
2065                2070                2075                2080
Arg Ala Ser Tyr Ile Leu Arg Leu Glu Glu Ile Ser Pro Trp Leu Ala
                2085                2090                2095    
Ala Met Thr Asn Thr Glu Ile Ala Leu Pro Gly Glu Val Ser Ala Arg
            2100                2105                2110        
Asp Thr Val Thr Ile His Ser Val Gly Gly Thr Ile Thr Ile Leu Pro
        2115                2120                2125            
Thr Lys Thr Lys Pro Lys Lys Leu Leu Phe Leu Gly Ser Asp Gly Lys
    2130                2135                2140                
Ser Tyr Pro Tyr Leu Phe Lys Gly Leu Glu Asp Leu His Leu Asp Glu
2145                2150                2155                2160
Arg Ile Met Gln Phe Leu Ser Ile Val Asn Thr Met Phe Ala Thr Ile
                2165                2170                2175    
Asn Arg Gln Glu Thr Pro Arg Phe His Ala Arg His Tyr Ser Val Thr
            2180                2185                2190        
Pro Leu Gly Thr Arg Ser Gly Leu Ile Gln Trp Val Asp Gly Ala Thr
        2195                2200                2205            
Pro Leu Phe Gly Leu Tyr Lys Arg Trp Gln Gln Arg Glu Ala Ala Leu
    2210                2215                2220                
Gln Ala Gln Lys Ala Gln Asp Ser Tyr Gln Thr Pro Gln Asn Pro Gly
2225                2230                2235                2240
Ile Val Pro Arg Pro Ser Glu Leu Tyr Tyr Ser Lys Ile Gly Pro Ala
                2245                2250                2255    
Leu Lys Thr Val Gly Leu Ser Leu Asp Val Ser Arg Arg Asp Trp Pro
            2260                2265                2270        
Leu His Val Met Lys Ala Val Leu Glu Glu Leu Met Glu Ala Thr Pro
        2275                2280                2285            
Pro Asn Leu Leu Ala Lys Glu Leu Trp Ser Ser Cys Thr Thr Pro Asp
    2290                2295                2300                
Glu Trp Trp Arg Val Thr Gln Ser Tyr Ala Arg Ser Thr Ala Val Met
2305                2310                2315                2320
Ser Met Val Gly Tyr Ile Ile Gly Leu Gly Asp Arg His Leu Asp Asn
                2325                2330                2335    
Val Leu Ile Asp Met Thr Thr Gly Glu Val Val His Ile Asp Tyr Asn
            2340                2345                2350        
Val Cys Phe Glu Lys Gly Lys Ser Leu Arg Val Pro Glu Lys Val Pro
        2355                2360                2365            
Phe Arg Met Thr Gln Asn Ile Glu Thr Ala Leu Gly Val Thr Gly Val
    2370                2375                2380                
Glu Gly Val Phe Arg Leu Ser Cys Glu Gln Val Leu His Ile Met Arg
2385                2390                2395                2400
Arg Gly Arg Glu Thr Leu Leu Thr Leu Leu Glu Ala Phe Val Tyr Asp
                2405                2410                2415    
Pro Leu Val Asp Trp Thr Ala Gly Gly Glu Ala Gly Phe Ala Gly Ala
            2420                2425                2430        
Val Tyr Gly Gly Gly Gly Gln Gln Ala Glu Ser Lys Gln Ser Lys Arg
        2435                2440                2445            
Glu Met Glu Arg Glu Ile Thr Arg Ser Leu Phe Ser Ser Arg Val Ala
    2450                2455                2460                
Glu Ile Lys Val Asn Trp Phe Lys Asn Arg Asp Glu Met Leu Val Val
2465                2470                2475                2480
Leu Pro Lys Leu Asp Gly Ser Leu Asp Glu Tyr Leu Ser Leu Gln Glu
                2485                2490                2495    
Gln Leu Thr Asp Val Glu Lys Leu Gln Gly Lys Leu Leu Glu Glu Ile
            2500                2505                2510        
Glu Phe Leu Glu Gly Ala Glu Gly Val Asp His Pro Ser His Thr Leu
        2515                2520                2525            
Gln His Arg Tyr Ser Glu His Thr Gln Leu Gln Thr Gln Gln Arg Ala
    2530                2535                2540                
Val Gln Glu Ala Ile Gln Val Lys Leu Asn Glu Phe Glu Gln Trp Ile
2545                2550                2555                2560
Thr His Tyr Gln Ala Ala Phe Asn Asn Leu Glu Ala Thr Gln Leu Ala
                2565                2570                2575    
Ser Leu Leu Gln Glu Ile Ser Thr Gln Met Asp Leu Gly Pro Pro Ser
            2580                2585                2590        
Tyr Val Pro Ala Thr Ala Phe Leu Gln Asn Ala Gly Gln Ala His Leu
        2595                2600                2605            
Ile Ser Gln Cys Glu Gln Leu Glu Gly Glu Val Gly Ala Leu Leu Gln
    2610                2615                2620                
Gln Arg Arg Ser Val Leu Arg Gly Cys Leu Glu Gln Leu His His Tyr
2625                2630                2635                2640
Ala Thr Val Ala Leu Gln Tyr Pro Lys Ala Ile Phe Gln Lys His Arg
                2645                2650                2655    
Ile Glu Gln Trp Lys Thr Trp Met Glu Glu Leu Ile Cys Asn Thr Thr
            2660                2665                2670        
Val Glu Arg Cys Gln Glu Leu Tyr Arg Lys Tyr Glu Met Gln Tyr Ala
        2675                2680                2685            
Pro Gln Pro Pro Pro Thr Val Cys Gln Phe Ile Thr Ala Thr Glu Met
    2690                2695                2700                
Thr Leu Gln Arg Tyr Ala Ala Asp Ile Asn Ser Arg Leu Ile Arg Gln
2705                2710                2715                2720
Val Glu Arg Leu Lys Gln Glu Ala Val Thr Val Pro Val Cys Glu Asp
                2725                2730                2735    
Gln Leu Lys Glu Ile Glu Arg Cys Ile Lys Val Phe Leu His Glu Asn
            2740                2745                2750        
Gly Glu Glu Gly Ser Leu Ser Leu Ala Ser Val Ile Ile Ser Ala Leu
        2755                2760                2765            
Cys Thr Leu Thr Arg Arg Asn Leu Met Met Glu Gly Ala Ala Ser Ser
    2770                2775                2780                
Ala Gly Glu Gln Leu Val Asp Leu Thr Ser Arg Asp Gly Ala Trp Phe
2785                2790                2795                2800
Leu Glu Glu Leu Cys Ser Met Ser Gly Asn Val Thr Cys Leu Val Gln
                2805                2810                2815    
Leu Leu Lys Gln Cys His Leu Val Pro Gln Asp Leu Asp Ile Pro Asn
            2820                2825                2830        
Pro Met Glu Ala Ser Glu Thr Val His Leu Ala Asn Gly Val Tyr Thr
        2835                2840                2845            
Ser Leu Gln Glu Leu Asn Ser Asn Phe Arg Gln Ile Ile Phe Pro Glu
    2850                2855                2860                
Ala Leu Arg Cys Leu Met Lys Gly Glu Tyr Thr Leu Glu Ser Met Leu
2865                2870                2875                2880
His Glu Leu Asp Gly Leu Ile Glu Gln Thr Thr Asp Gly Val Pro Leu
                2885                2890                2895    
Gln Thr Leu Val Glu Ser Leu Gln Ala Tyr Leu Arg Asn Ala Ala Met
            2900                2905                2910        
Gly Leu Glu Glu Glu Thr His Ala His Tyr Ile Asp Val Ala Arg Leu
        2915                2920                2925            
Leu His Ala Gln Tyr Gly Glu Leu Ile Gln Pro Arg Asn Gly Ser Val
    2930                2935                2940                
Asp Glu Thr Pro Lys Met Ser Ala Gly Gln Met Leu Leu Val Ala Phe
2945                2950                2955                2960
Asp Gly Met Phe Ala Gln Val Glu Thr Ala Phe Ser Leu Leu Val Glu
                2965                2970                2975    
Lys Leu Asn Lys Met Glu Ile Pro Ile Ala Trp Arg Lys Ile Asp Ile
            2980                2985                2990        
Ile Arg Glu Ala Arg Ser Thr Gln Val Asn Phe Phe Asp Asp Asp Asn
        2995                3000                3005            
His Arg Gln Val Leu Glu Glu Ile Phe Phe Leu Lys Arg Leu Gln Thr
    3010                3015                3020                
Ile Lys Glu Phe Phe Arg Leu Cys Gly Thr Phe Ser Lys Thr Leu Ser
3025                3030                3035                3040
Gly Ser Ser Ser Leu Glu Asp Gln Asn Thr Val Asn Gly Pro Val Gln
                3045                3050                3055    
Ile Val Asn Val Lys Thr Leu Phe Arg Asn Ser Cys Phe Ser Glu Asp
            3060                3065                3070        
Gln Met Ala Lys Pro Ile Lys Ala Phe Thr Ala Asp Phe Val Arg Gln
        3075                3080                3085            
Leu Leu Ile Gly Leu Pro Asn Gln Ala Leu Gly Leu Thr Leu Cys Ser
    3090                3095                3100                
Phe Ile Ser Ala Leu Gly Val Asp Ile Ile Ala Gln Val Glu Ala Lys
3105                3110                3115                3120
Asp Phe Gly Ala Glu Ser Lys Val Ser Val Asp Asp Leu Cys Lys Lys
                3125                3130                3135    
Ala Val Glu His Asn Ile Gln Ile Gly Lys Phe Ser Gln Leu Val Met
            3140                3145                3150        
Asn Arg Ala Thr Val Leu Ala Ser Ser Tyr Asp Thr Ala Trp Lys Lys
        3155                3160                3165            
His Asp Leu Val Arg Arg Leu Glu Thr Ser Ile Ser Ser Cys Lys Thr
    3170                3175                3180                
Ser Leu Gln Arg Val Gln Leu His Ile Ala Met Phe Gln Trp Gln His
3185                3190                3195                3200
Glu Asp Leu Leu Ile Asn Arg Pro Gln Ala Met Ser Val Thr Pro Pro
                3205                3210                3215    
Pro Arg Ser Ala Ile Leu Thr Ser Met Lys Lys Lys Leu His Thr Leu
            3220                3225                3230        
Ser Gln Ile Glu Thr Ser Ile Ala Thr Val Gln Glu Lys Leu Ala Ala
        3235                3240                3245            
Leu Glu Ser Ser Ile Glu Gln Arg Leu Lys Trp Ala Gly Gly Ala Asn
    3250                3255                3260                
Pro Ala Leu Ala Pro Val Leu Gln Asp Phe Glu Ala Thr Ile Ala Glu
3265                3270                3275                3280
Arg Arg Asn Leu Val Leu Lys Glu Ser Gln Arg Ala Ser Gln Val Thr
                3285                3290                3295    
Phe Leu Cys Ser Asn Ile Ile His Phe Glu Ser Leu Arg Thr Arg Thr
            3300                3305                3310        
Ala Glu Ala Leu Asn Leu Asp Ala Ala Leu Phe Glu Leu Ile Lys Arg
        3315                3320                3325            
Cys Gln Gln Met Cys Ser Phe Ala Ser Gln Phe Asn Ser Ser Val Ser
    3330                3335                3340                
Glu Leu Glu Leu Arg Leu Leu Gln Arg Val Asp Thr Gly Leu Glu His
3345                3350                3355                3360
Pro Ile Gly Ser Ser Glu Trp Leu Leu Ser Ala His Lys Gln Leu Thr
                3365                3370                3375    
Gln Asp Met Ser Thr Gln Arg Ala Ile Gln Thr Glu Lys Glu Gln Gln
            3380                3385                3390        
Ile Glu Thr Val Cys Glu Thr Ile Gln Asn Leu Val Asp Asn Ile Lys
        3395                3400                3405            
Thr Val Leu Thr Gly His Asn Arg Gln Leu Gly Asp Val Lys His Leu
    3410                3415                3420                
Leu Lys Ala Met Ala Lys Asp Glu Glu Ala Ala Leu Ala Asp Gly Glu
3425                3430                3435                3440
Asp Val Pro Tyr Glu Asn Ser Val Arg Gln Phe Leu Gly Glu Tyr Lys
                3445                3450                3455    
Ser Trp Gln Asp Asn Ile Gln Thr Val Leu Phe Thr Leu Val Gln Ala
            3460                3465                3470        
Met Gly Gln Val Arg Ser Gln Glu His Val Glu Met Leu Gln Glu Ile
        3475                3480                3485            
Thr Pro Thr Leu Lys Glu Leu Lys Thr Gln Ser Gln Ser Ile Tyr Asn
    3490                3495                3500                
Asn Leu Val Ser Phe Ala Ser Pro Leu Val Thr Asp Ala Thr Asn Glu
3505                3510                3515                3520
Cys Ser Ser Pro Thr Ser Ser Ala Thr Tyr Gln Pro Ser Phe Ala Ala
                3525                3530                3535    
Ala Val Arg Ser Asn Thr Gly Gln Lys Thr Gln Pro Asp Val Met Ser
            3540                3545                3550        
Gln Asn Ala Arg Lys Leu Ile Gln Lys Asn Leu Ala Thr Ser Ala Asp
        3555                3560                3565            
Thr Pro Pro Ser Thr Val Pro Gly Thr Gly Lys Ser Val Ala Cys Ser
    3570                3575                3580                
Pro Lys Lys Ala Val Arg Asp Pro Lys Thr Gly Lys Ala Val Gln Glu
3585                3590                3595                3600
Arg Asn Ser Tyr Ala Val Ser Val Trp Lys Arg Val Lys Ala Lys Leu
                3605                3610                3615    
Glu Gly Arg Asp Val Asp Pro Asn Arg Arg Met Ser Val Ala Glu Gln
            3620                3625                3630        
Val Asp Tyr Val Ile Lys Glu Ala Thr Asn Leu Asp Asn Leu Ala Gln
        3635                3640                3645            
Leu Tyr Glu Gly Trp Thr Ala Trp Val
    3650                3655        


<210> 8858
<211> 545
<212> PRT
<213> Homo sapiens

<400> 8858
Met Thr Trp Ala Leu Glu Val Ala Val Leu Met Lys Lys Ser Glu Thr
 1               5                  10                  15      
Tyr Ala Pro Leu Phe Cys Leu Pro Ser Phe His Lys Phe Cys Lys Gly
            20                  25                  30          
Leu Leu Ala Asn Thr Leu Val Glu Asp Val Asn Ile Cys Leu Gln Ala
        35                  40                  45              
Cys Ser Ser Leu His Ala Leu Ser Ser Ser Leu Pro Asp Asp Leu Leu
    50                  55                  60                  
Gln Arg Cys Val Asp Val Cys Arg Val Gln Leu Val His Arg Gly Thr
65                  70                  75                  80  
Arg Ile Arg Gln Ala Phe Gly Lys Leu Leu Lys Ser Ile Pro Leu Asp
                85                  90                  95      
Val Val Leu Ser Asn Asn Asn His Thr Glu Ile Gln Glu Ile Ser Leu
            100                 105                 110         
Ala Leu Arg Ser His Met Ser Lys Ala Pro Ser Asn Thr Phe His Pro
        115                 120                 125             
Gln Asp Phe Ser Asp Val Ile Ser Phe Ile Leu Tyr Gly Asn Ser His
    130                 135                 140                 
Arg Thr Gly Lys Asp Asn Trp Leu Glu Arg Leu Phe Tyr Ser Cys Gln
145                 150                 155                 160 
Arg Leu Asp Lys Cys Asp Gln Ser Thr Ile Pro Arg Asn Leu Leu Lys
                165                 170                 175     
Thr Asp Ala Ile Phe Trp Gln Trp Ala Ile Trp Glu Ala Ala Gln Phe
            180                 185                 190         
Thr Val Leu Ser Lys Leu Arg Thr Pro Leu Gly Arg Ala Gln Asp Thr
        195                 200                 205             
Phe Gln Thr Ile Glu Gly Ile Ile Arg Ser Leu Ala Ala His Thr Leu
    210                 215                 220                 
Asn Pro Asp Gln Asp Val Ser Gln Trp Thr Thr Ala Asp Asn Asp Glu
225                 230                 235                 240 
Gly His Gly Asn Asn Gln Leu Arg Leu Val Leu Leu Leu Gln Tyr Leu
                245                 250                 255     
Glu Asn Leu Glu Lys Leu Met Tyr Asn Val Tyr Glu Gly Cys Ala Asn
            260                 265                 270         
Ala Leu Thr Ser Pro Pro Lys Val Ile Arg Ala Phe Phe Tyr Thr Ser
        275                 280                 285             
Cys Gln Thr Cys Gln Asp Trp Leu Thr Arg Ile Arg Leu Ser Ile Met
    290                 295                 300                 
Arg Val Gly Leu Leu Ala Gly Gln Pro Ala Val Thr Val Arg His Gly
305                 310                 315                 320 
Phe Asp Leu Leu Thr Glu Met Lys Thr Thr Ser Leu Ser Gln Gly Asn
                325                 330                 335     
Glu Leu Glu Ile Thr Ile Met Met Val Val Glu Ala Leu Cys Glu Leu
            340                 345                 350         
His Cys Pro Glu Ala Ile Gln Gly Ile Ala Val Trp Ser Ser Ser Ile
        355                 360                 365             
Val Gly Lys Asn Leu Leu Trp Ile Asn Ser Val Ala Gln Gln Ala Glu
    370                 375                 380                 
Gly Arg Phe Glu Lys Ala Ser Val Glu Tyr Gln Glu His Leu Cys Ala
385                 390                 395                 400 
Met Thr Gly Val Asp Cys Cys Ile Ser Ser Phe Asp Lys Leu Val Leu
                405                 410                 415     
Thr Leu Ala Asn Ala Gly Cys Asn Ser Ala Ser Pro Lys His Cys Leu
            420                 425                 430         
Asn Gly Glu Ser Arg Lys Thr Val Leu Ser Lys Pro Thr Asp Ser Ser
        435                 440                 445             
Pro Glu Val Ile Asn Tyr Leu Gly Asn Lys Cys Glu Cys Tyr Ile Ser
    450                 455                 460                 
Ile Ala Asp Cys Ala Ala Val Gln Glu Trp Gln Asn Ala Ile His Asp
465                 470                 475                 480 
Leu Lys Lys Ser Thr Ser Ser Thr Ser Leu Asn Leu Lys Ala Glu Phe
                485                 490                 495     
Asn Tyr Ile Lys Ser Leu Ser Ser Phe Glu Ser Gly Lys Phe Val Glu
            500                 505                 510         
Cys Thr Glu Gln Leu Glu Leu Leu Pro Gly Glu Asn Ile Asn Leu Leu
        515                 520                 525             
Ala Gly Gly Ser Lys Glu Lys Ile Asp Met Lys Asn Leu Leu Arg Asn
    530                 535                 540                 
Met
545 


<210> 8859
<211> 3680
<212> PRT
<213> Homo sapiens

<400> 8859
Met Ser Arg Arg Ala Pro Gly Ser Arg Leu Ser Ser Gly Gly Thr Lys
 1               5                  10                  15      
Tyr Pro Arg Ser Trp Asn Asp Trp Gln Pro Arg Thr Asp Ser Ala Ser
            20                  25                  30          
Ala Asp Pro Asp Asn Leu Lys Tyr Ser Ser Ser Arg Asp Arg Gly Gly
        35                  40                  45              
Ser Ser Ser Tyr Gly Leu Gln Pro Ser Asn Ser Ala Val Val Ser Arg
    50                  55                  60                  
Gln Arg His Asp Asp Thr Arg Val His Ala Asp Ile Gln Asn Asp Glu
65                  70                  75                  80  
Lys Gly Gly Tyr Ser Val Asn Gly Gly Ser Gly Glu Asn Thr Tyr Gly
                85                  90                  95      
Arg Lys Ser Leu Gly Gln Glu Leu Arg Val Asn Asn Val Thr Ser Pro
            100                 105                 110         
Glu Phe Thr Ser Val Gln His Gly Ser Arg Ala Leu Ala Thr Lys Asp
        115                 120                 125             
Met Arg Lys Ser Gln Glu Arg Ser Met Ser Tyr Ser Asp Glu Ser Arg
    130                 135                 140                 
Leu Ser Asn Leu Leu Arg Arg Ile Thr Arg Glu Asp Asp Arg Asp Arg
145                 150                 155                 160 
Arg Leu Ala Thr Val Lys Gln Leu Lys Glu Phe Ile Gln Gln Pro Glu
                165                 170                 175     
Asn Lys Leu Val Leu Val Lys Gln Leu Asp Asn Ile Leu Ala Ala Val
            180                 185                 190         
His Asp Val Leu Asn Glu Ser Ser Lys Leu Leu Gln Glu Leu Arg Gln
        195                 200                 205             
Glu Gly Ala Cys Cys Leu Gly Leu Leu Cys Ala Ser Leu Ser Tyr Glu
    210                 215                 220                 
Ala Glu Lys Ile Phe Lys Trp Ile Phe Ser Lys Phe Ser Ser Ser Ala
225                 230                 235                 240 
Lys Asp Glu Val Lys Leu Leu Tyr Leu Cys Ala Thr Tyr Lys Ala Leu
                245                 250                 255     
Glu Thr Val Gly Glu Lys Lys Ala Phe Ser Ser Val Met Gln Leu Val
            260                 265                 270         
Met Thr Ser Leu Gln Ser Ile Leu Glu Asn Val Asp Thr Pro Glu Leu
        275                 280                 285             
Leu Cys Lys Cys Val Lys Cys Ile Leu Leu Val Ala Arg Cys Tyr Pro
    290                 295                 300                 
His Ile Phe Ser Thr Asn Phe Arg Asp Thr Val Asp Ile Leu Val Gly
305                 310                 315                 320 
Trp His Ile Asp His Thr Gln Lys Pro Ser Leu Thr Gln Gln Val Ser
                325                 330                 335     
Gly Trp Leu Gln Ser Leu Glu Pro Phe Trp Val Ala Asp Leu Ala Phe
            340                 345                 350         
Ser Thr Thr Leu Leu Gly Gln Phe Leu Glu Asp Met Glu Ala Tyr Ala
        355                 360                 365             
Glu Asp Leu Ser His Val Ala Ser Gly Glu Ser Val Asp Glu Asp Val
    370                 375                 380                 
Pro Pro Pro Ser Val Ser Leu Pro Lys Leu Ala Ala Leu Leu Arg Val
385                 390                 395                 400 
Phe Ser Thr Val Val Arg Ser Ile Gly Glu Arg Phe Ser Pro Ile Arg
                405                 410                 415     
Gly Pro Pro Ile Thr Glu Ala Tyr Val Thr Asp Val Leu Tyr Arg Val
            420                 425                 430         
Met Arg Cys Val Thr Ala Ala Asn Gln Val Phe Phe Ser Glu Ala Val
        435                 440                 445             
Leu Thr Ala Ala Asn Glu Cys Val Gly Val Leu Leu Gly Ser Leu Asp
    450                 455                 460                 
Pro Ser Met Thr Ile His Cys Asp Met Val Ile Thr Tyr Gly Leu Asp
465                 470                 475                 480 
Gln Leu Glu Asn Cys Gln Thr Cys Gly Thr Asp Tyr Ile Ile Ser Val
                485                 490                 495     
Leu Asn Leu Leu Thr Leu Ile Val Glu Gln Ile Asn Thr Lys Leu Pro
            500                 505                 510         
Ser Ser Phe Val Glu Lys Leu Phe Ile Pro Ser Ser Lys Leu Leu Phe
        515                 520                 525             
Leu Arg Tyr His Lys Glu Lys Glu Val Val Ala Val Ala His Ala Val
    530                 535                 540                 
Tyr Gln Ala Val Leu Ser Leu Lys Asn Ile Pro Val Leu Glu Thr Ala
545                 550                 555                 560 
Tyr Lys Leu Ile Leu Gly Glu Met Thr Cys Ala Leu Asn Asn Leu Leu
                565                 570                 575     
His Ser Leu Gln Leu Pro Glu Ala Cys Ser Glu Ile Lys His Glu Ala
            580                 585                 590         
Phe Lys Asn His Val Phe Asn Val Asp Asn Ala Lys Phe Val Val Ile
        595                 600                 605             
Phe Asp Leu Ser Ala Leu Thr Thr Ile Gly Asn Ala Lys Asn Ser Leu
    610                 615                 620                 
Ile Gly Met Trp Ala Leu Ser Pro Thr Val Phe Ala Leu Leu Ser Lys
625                 630                 635                 640 
Asn Leu Met Ile Val His Ser Asp Leu Ala Val His Phe Pro Ala Ile
                645                 650                 655     
Gln Tyr Ala Val Leu Tyr Thr Leu Tyr Ser His Cys Thr Arg His Asp
            660                 665                 670         
His Phe Ile Ser Ser Ser Leu Ser Ser Ser Ser Pro Ser Leu Phe Asp
        675                 680                 685             
Gly Ala Val Ile Ser Thr Val Thr Thr Ala Thr Lys Lys His Phe Ser
    690                 695                 700                 
Ile Ile Leu Asn Leu Leu Gly Ile Leu Leu Lys Lys Asp Asn Leu Asn
705                 710                 715                 720 
Gln Asp Thr Arg Lys Leu Leu Met Thr Trp Ala Leu Glu Ala Ala Val
                725                 730                 735     
Leu Met Lys Lys Ser Glu Thr Tyr Ala Pro Leu Phe Ser Leu Pro Ser
            740                 745                 750         
Phe His Lys Phe Cys Lys Gly Leu Leu Ala Asn Thr Leu Val Glu Asp
        755                 760                 765             
Val Asn Ile Cys Leu Gln Ala Cys Ser Ser Leu His Ala Leu Ser Ser
    770                 775                 780                 
Ser Leu Pro Asp Asp Leu Leu Gln Arg Cys Val Asp Val Cys Arg Val
785                 790                 795                 800 
Gln Leu Val His Ser Gly Thr Arg Ile Arg Gln Ala Phe Gly Lys Leu
                805                 810                 815     
Leu Lys Ser Ile Pro Leu Asp Val Val Leu Ser Asn Asn Asn His Thr
            820                 825                 830         
Glu Ile Gln Glu Ile Ser Leu Ala Leu Arg Ser His Met Ser Lys Ala
        835                 840                 845             
Pro Ser Asn Thr Phe His Pro Gln Asp Phe Ser Asp Val Ile Ser Phe
    850                 855                 860                 
Ile Leu Tyr Gly Asn Ser His Arg Thr Gly Lys Asp Asn Trp Leu Glu
865                 870                 875                 880 
Arg Leu Phe Tyr Ser Cys Gln Arg Leu Asp Lys Arg Asp Gln Ser Thr
                885                 890                 895     
Ile Pro Arg Asn Leu Leu Lys Thr Asp Ala Val Leu Trp Gln Trp Ala
            900                 905                 910         
Ile Trp Glu Ala Ala Gln Phe Thr Val Leu Ser Lys Leu Arg Thr Pro
        915                 920                 925             
Leu Gly Arg Ala Gln Asp Thr Phe Gln Thr Ile Glu Gly Ile Ile Arg
    930                 935                 940                 
Ser Leu Ala Ala His Thr Leu Asn Pro Asp Gln Asp Val Ser Gln Trp
945                 950                 955                 960 
Thr Thr Ala Asp Asn Asp Glu Gly His Gly Asn Asn Gln Leu Arg Leu
                965                 970                 975     
Val Leu Leu Leu Gln Tyr Leu Glu Asn Leu Glu Lys Leu Met Tyr Asn
            980                 985                 990         
Ala Tyr Glu Gly Cys Ala Asn Ala Leu Thr Ser Pro Pro Lys Val Ile
        995                 1000                1005            
Arg Thr Phe Phe Tyr Thr Asn Arg Gln Thr Cys Gln Asp Trp Leu Thr
    1010                1015                1020                
Arg Ile Arg Leu Ser Ile Met Arg Val Gly Leu Leu Ala Gly Gln Pro
1025                1030                1035                1040
Ala Val Thr Val Arg His Gly Phe Asp Leu Leu Thr Glu Met Lys Thr
                1045                1050                1055    
Thr Ser Leu Ser Gln Gly Asn Glu Leu Glu Val Thr Ile Met Met Val
            1060                1065                1070        
Val Glu Ala Leu Cys Glu Leu His Cys Pro Glu Ala Ile Gln Gly Ile
        1075                1080                1085            
Ala Val Trp Ser Ser Ser Ile Val Gly Lys Asn Leu Leu Trp Ile Asn
    1090                1095                1100                
Ser Val Ala Gln Gln Ala Glu Gly Arg Phe Glu Lys Ala Ser Val Glu
1105                1110                1115                1120
Tyr Gln Glu His Leu Cys Ala Met Thr Gly Val Asp Cys Cys Ile Ser
                1125                1130                1135    
Ser Phe Asp Lys Ser Val Leu Thr Leu Ala Asn Ala Gly Arg Asn Ser
            1140                1145                1150        
Ala Ser Pro Lys His Ser Leu Asn Gly Glu Ser Arg Lys Thr Val Leu
        1155                1160                1165            
Ser Lys Pro Thr Asp Ser Ser Pro Glu Val Ile Asn Tyr Leu Gly Asn
    1170                1175                1180                
Lys Ala Cys Glu Cys Tyr Ile Ser Ile Ala Asp Trp Ala Ala Val Gln
1185                1190                1195                1200
Glu Trp Gln Asn Ala Ile His Asp Leu Lys Lys Ser Thr Ser Ser Thr
                1205                1210                1215    
Ser Leu Asn Leu Lys Ala Asp Phe Asn Tyr Ile Lys Ser Leu Ser Ser
            1220                1225                1230        
Phe Glu Ser Gly Lys Phe Val Glu Cys Thr Glu Gln Leu Glu Leu Leu
        1235                1240                1245            
Pro Gly Glu Asn Ile Asn Leu Leu Ala Gly Gly Ser Lys Glu Lys Ile
    1250                1255                1260                
Asp Met Lys Lys Leu Leu Pro Asn Met Leu Ser Pro Asp Pro Arg Glu
1265                1270                1275                1280
Leu Gln Lys Ser Ile Glu Val Gln Leu Leu Arg Ser Ser Val Cys Leu
                1285                1290                1295    
Ala Thr Ala Leu Asn Pro Ile Glu Gln Asp Gln Lys Trp Gln Ser Ile
            1300                1305                1310        
Thr Glu Asn Val Val Lys Tyr Leu Lys Gln Thr Ser Arg Ile Ala Ile
        1315                1320                1325            
Gly Pro Leu Arg Leu Ser Thr Leu Thr Val Ser Gln Ser Leu Pro Val
    1330                1335                1340                
Leu Ser Thr Leu Gln Leu Tyr Cys Ser Ser Ala Leu Glu Asn Thr Val
1345                1350                1355                1360
Ser Asn Arg Leu Ser Thr Glu Asp Cys Leu Ile Pro Leu Phe Ser Glu
                1365                1370                1375    
Ala Leu Arg Ser Cys Lys Gln His Asp Val Arg Pro Trp Met Gln Ala
            1380                1385                1390        
Leu Arg Tyr Thr Met Tyr Gln Asn Gln Leu Leu Glu Lys Ile Lys Glu
        1395                1400                1405            
Gln Thr Val Pro Ile Arg Ser His Leu Met Glu Leu Gly Leu Thr Ala
    1410                1415                1420                
Ala Lys Phe Ala Arg Lys Arg Gly Asn Val Ser Leu Ala Thr Arg Leu
1425                1430                1435                1440
Leu Ala Gln Cys Ser Glu Val Gln Leu Gly Lys Thr Thr Thr Ala Gln
                1445                1450                1455    
Asp Leu Val Gln His Phe Lys Lys Leu Ser Thr Gln Gly Gln Val Asp
            1460                1465                1470        
Glu Lys Trp Gly Pro Glu Leu Asp Ile Glu Lys Thr Lys Leu Leu Tyr
        1475                1480                1485            
Thr Ala Gly Gln Ser Thr His Ala Met Glu Met Leu Ser Ser Cys Ala
    1490                1495                1500                
Ile Ser Phe Cys Lys Ser Val Lys Ala Glu Tyr Ala Val Ala Lys Ser
1505                1510                1515                1520
Ile Leu Thr Leu Ala Lys Trp Ile Gln Ala Glu Trp Lys Glu Ile Ser
                1525                1530                1535    
Gly Gln Leu Lys Gln Val Tyr Arg Ala Gln His Gln Gln Asn Phe Thr
            1540                1545                1550        
Gly Leu Ser Thr Leu Ser Lys Asn Ile Leu Thr Leu Ile Glu Leu Pro
        1555                1560                1565            
Ser Val Asn Thr Met Glu Glu Glu Tyr Pro Arg Ile Glu Ser Glu Ser
    1570                1575                1580                
Thr Val His Ile Gly Val Gly Glu Pro Asp Phe Ile Leu Gly Gln Leu
1585                1590                1595                1600
Tyr His Leu Ser Ser Val Gln Ala Pro Glu Val Ala Lys Ser Trp Ala
                1605                1610                1615    
Ala Leu Ala Ser Trp Ala Tyr Arg Trp Gly Arg Lys Val Val Asp Asn
            1620                1625                1630        
Ala Ser Gln Gly Glu Gly Val Arg Leu Leu Pro Arg Glu Lys Ser Glu
        1635                1640                1645            
Val Gln Asn Leu Leu Pro Asp Thr Ile Thr Glu Glu Glu Lys Glu Arg
    1650                1655                1660                
Ile Tyr Gly Ile Leu Gly Gln Ala Val Cys Arg Pro Ala Gly Ile Gln
1665                1670                1675                1680
Ala Arg Lys Thr Cys Ile Leu Cys Thr Ile Phe Leu Gln Asp Glu Asp
                1685                1690                1695    
Ile Thr Leu Gln Ile Thr Glu Ser Glu Asp Asn Glu Glu Asp Asp Met
            1700                1705                1710        
Val Asp Val Ile Trp Arg Gln Leu Ile Ser Ser Cys Pro Trp Leu Ser
        1715                1720                1725            
Glu Leu Asp Glu Ser Ala Thr Glu Gly Val Ile Lys Val Trp Arg Lys
    1730                1735                1740                
Val Val Asp Arg Ile Phe Ser Leu Tyr Lys Leu Ser Cys Ser Ala Tyr
1745                1750                1755                1760
Phe Thr Phe Leu Lys Leu Asn Ala Gly Gln Ile Pro Leu Asp Glu Asp
                1765                1770                1775    
Asp Pro Arg Leu His Leu Ser His Arg Val Glu Gln Ser Thr Asp Asp
            1780                1785                1790        
Met Ile Val Met Ala Thr Leu Arg Leu Leu Arg Leu Leu Val Lys His
        1795                1800                1805            
Ala Gly Glu Leu Arg Gln Tyr Leu Glu His Gly Leu Glu Thr Thr Pro
    1810                1815                1820                
Thr Ala Pro Trp Arg Gly Ile Ile Pro Gln Leu Phe Ser Arg Leu Asn
1825                1830                1835                1840
His Pro Glu Val Tyr Val Arg Gln Ser Ile Cys Asn Leu Leu Cys Arg
                1845                1850                1855    
Val Ala Gln Asp Ser Pro His Leu Ile Leu Tyr Pro Ala Ile Val Gly
            1860                1865                1870        
Thr Ile Ser Leu Ser Ser Glu Ser Gln Ala Ser Gly Asn Lys Phe Ser
        1875                1880                1885            
Thr Ala Ile Pro Thr Leu Leu Gly Asn Ile Gln Gly Glu Glu Leu Leu
    1890                1895                1900                
Val Ser Glu Cys Glu Gly Gly Ser Pro Pro Ala Ser Gln Asp Ser Asn
1905                1910                1915                1920
Lys Asp Glu Pro Lys Ser Gly Leu Asn Glu Asp Gln Ala Met Met Gln
                1925                1930                1935    
Asp Cys Tyr Ser Lys Ile Val Asp Lys Leu Ser Ser Ala Asn Pro Thr
            1940                1945                1950        
Met Val Leu Gln Val Gln Met Leu Val Ala Glu Leu Arg Arg Val Thr
        1955                1960                1965            
Val Leu Trp Asp Glu Leu Trp Leu Gly Val Leu Leu Gln Gln His Met
    1970                1975                1980                
Tyr Val Leu Arg Arg Ile Gln Gln Leu Glu Asp Glu Val Lys Arg Val
1985                1990                1995                2000
Gln Asn Asn Asn Thr Leu Arg Lys Glu Glu Lys Ile Ala Ile Met Arg
                2005                2010                2015    
Glu Lys His Thr Ala Leu Met Lys Pro Ile Val Phe Ala Leu Glu His
            2020                2025                2030        
Val Arg Ser Ile Thr Ala Ala Pro Ala Glu Thr Pro His Glu Lys Trp
        2035                2040                2045            
Phe Gln Asp Asn Tyr Gly Asp Ala Ile Glu Asn Ala Leu Glu Lys Leu
    2050                2055                2060                
Lys Thr Pro Leu Asn Pro Ala Lys Pro Gly Ser Ser Trp Ile Pro Phe
2065                2070                2075                2080
Lys Glu Ile Met Leu Ser Leu Gln Gln Arg Ala Gln Lys Arg Ala Ser
                2085                2090                2095    
Tyr Ile Leu Arg Leu Glu Glu Ile Ser Pro Trp Leu Ala Ala Met Thr
            2100                2105                2110        
Asn Thr Glu Ile Ala Leu Pro Gly Glu Val Ser Ala Arg Asp Thr Val
        2115                2120                2125            
Thr Ile His Ser Val Gly Gly Thr Ile Thr Ile Leu Pro Thr Lys Thr
    2130                2135                2140                
Lys Pro Lys Lys Leu Leu Phe Leu Gly Ser Asp Gly Lys Ser Tyr Pro
2145                2150                2155                2160
Tyr Leu Phe Lys Gly Leu Glu Asp Leu His Leu Asp Glu Arg Ile Met
                2165                2170                2175    
Gln Phe Leu Ser Ile Val Asn Thr Met Phe Ala Thr Ile Asn Arg Gln
            2180                2185                2190        
Glu Thr Pro Arg Phe His Ala Arg His Tyr Ser Val Thr Pro Leu Gly
        2195                2200                2205            
Thr Arg Ser Gly Leu Ile Gln Trp Val Asp Gly Ala Thr Pro Leu Phe
    2210                2215                2220                
Gly Leu Tyr Lys Arg Trp Gln Gln Arg Glu Ala Ala Leu Gln Ala Gln
2225                2230                2235                2240
Lys Ala Gln Asp Ser Tyr Gln Thr Pro Gln Asn Pro Gly Ile Val Pro
                2245                2250                2255    
Arg Pro Ser Glu Leu Tyr Tyr Ser Lys Ile Gly Pro Ala Leu Lys Thr
            2260                2265                2270        
Val Gly Leu Ser Leu Asp Val Ser Arg Arg Asp Trp Pro Leu His Val
        2275                2280                2285            
Met Lys Ala Val Leu Glu Glu Leu Met Glu Ala Thr Pro Pro Asn Leu
    2290                2295                2300                
Leu Ala Lys Glu Leu Trp Ser Ser Cys Thr Thr Pro Asp Glu Trp Trp
2305                2310                2315                2320
Arg Val Thr Gln Ser Tyr Ala Arg Ser Thr Ala Val Met Ser Met Val
                2325                2330                2335    
Gly Tyr Ile Ile Gly Leu Gly Asp Arg His Leu Asp Asn Val Leu Ile
            2340                2345                2350        
Asp Met Thr Thr Gly Glu Val Val His Ile Asp Tyr Asn Val Cys Phe
        2355                2360                2365            
Glu Lys Gly Lys Ser Leu Arg Val Pro Glu Lys Val Pro Phe Arg Met
    2370                2375                2380                
Thr Gln Asn Ile Glu Thr Ala Leu Gly Val Thr Gly Val Glu Gly Val
2385                2390                2395                2400
Phe Arg Leu Ser Cys Glu Gln Val Leu His Ile Met Arg Arg Gly Arg
                2405                2410                2415    
Glu Thr Leu Leu Thr Leu Leu Glu Ala Phe Val Tyr Asp Pro Leu Val
            2420                2425                2430        
Asp Trp Thr Ala Gly Gly Glu Ala Gly Phe Ala Gly Ala Val Tyr Gly
        2435                2440                2445            
Gly Gly Gly Gln Gln Ala Glu Ser Lys Gln Ser Lys Arg Glu Met Glu
    2450                2455                2460                
Arg Glu Ile Thr Arg Ser Leu Phe Ser Ser Arg Val Ala Glu Ile Lys
2465                2470                2475                2480
Val Asn Trp Phe Lys Asn Arg Asp Glu Met Leu Val Val Leu Pro Lys
                2485                2490                2495    
Leu Asp Gly Ser Leu Asp Glu Tyr Leu Ser Leu Gln Glu Gln Leu Thr
            2500                2505                2510        
Asp Val Glu Lys Leu Gln Gly Lys Leu Leu Glu Glu Ile Glu Phe Leu
        2515                2520                2525            
Glu Gly Ala Glu Gly Val Asp His Pro Ser His Thr Leu Gln His Arg
    2530                2535                2540                
Tyr Ser Glu His Thr Gln Leu Gln Thr Gln Gln Arg Ala Val Gln Glu
2545                2550                2555                2560
Ala Ile Gln Val Lys Leu Asn Glu Phe Glu Gln Trp Ile Thr His Tyr
                2565                2570                2575    
Gln Ala Ala Phe Asn Asn Leu Glu Ala Thr Gln Leu Ala Ser Leu Leu
            2580                2585                2590        
Gln Glu Ile Ser Thr Gln Met Asp Leu Gly Pro Pro Ser Tyr Val Pro
        2595                2600                2605            
Ala Thr Ala Phe Leu Gln Asn Ala Gly Gln Ala His Leu Ile Ser Gln
    2610                2615                2620                
Cys Glu Gln Leu Glu Gly Glu Val Gly Ala Leu Leu Gln Gln Arg Arg
2625                2630                2635                2640
Ser Val Leu Arg Gly Cys Leu Glu Gln Leu His His Tyr Ala Thr Val
                2645                2650                2655    
Ala Leu Gln Tyr Pro Lys Ala Ile Phe Gln Lys His Arg Ile Glu Gln
            2660                2665                2670        
Trp Lys Thr Trp Met Glu Glu Leu Ile Cys Asn Thr Thr Val Glu Arg
        2675                2680                2685            
Cys Gln Glu Leu Tyr Arg Lys Tyr Glu Met Gln Tyr Ala Pro Gln Pro
    2690                2695                2700                
Pro Pro Thr Val Cys Gln Phe Ile Thr Ala Thr Glu Met Thr Leu Gln
2705                2710                2715                2720
Arg Tyr Ala Ala Asp Ile Asn Ser Arg Leu Ile Arg Gln Val Glu Arg
                2725                2730                2735    
Leu Lys Gln Glu Ala Val Thr Val Pro Val Cys Glu Asp Gln Leu Lys
            2740                2745                2750        
Glu Ile Glu Arg Cys Ile Lys Val Phe Leu His Glu Asn Gly Glu Glu
        2755                2760                2765            
Gly Ser Leu Ser Leu Ala Ser Val Ile Ile Ser Ala Leu Cys Thr Leu
    2770                2775                2780                
Thr Arg Arg Asn Leu Met Met Glu Gly Ala Ala Ser Ser Ala Gly Glu
2785                2790                2795                2800
Gln Leu Val Asp Leu Thr Ser Arg Asp Gly Ala Trp Phe Leu Glu Glu
                2805                2810                2815    
Leu Cys Ser Met Ser Gly Asn Val Thr Cys Leu Val Gln Leu Leu Lys
            2820                2825                2830        
Gln Cys His Leu Val Pro Gln Asp Leu Asp Ile Pro Asn Pro Met Glu
        2835                2840                2845            
Ala Ser Glu Thr Val His Leu Ala Asn Gly Val Tyr Thr Ser Leu Gln
    2850                2855                2860                
Glu Leu Asn Ser Asn Phe Arg Gln Ile Ile Phe Pro Glu Ala Leu Arg
2865                2870                2875                2880
Cys Leu Met Lys Gly Glu Tyr Thr Leu Glu Ser Met Leu His Glu Leu
                2885                2890                2895    
Asp Gly Leu Ile Glu Gln Thr Thr Asp Gly Val Pro Leu Gln Thr Leu
            2900                2905                2910        
Val Glu Ser Leu Gln Ala Tyr Leu Arg Asn Ala Ala Met Gly Leu Glu
        2915                2920                2925            
Glu Glu Thr His Ala His Tyr Ile Asp Val Ala Arg Gln Val Asn Ala
    2930                2935                2940                
Gly Cys Ala Val Ser Leu Leu Leu His Ala Gln Tyr Gly Glu Leu Ile
2945                2950                2955                2960
Gln Pro Arg Asn Gly Ser Val Asp Glu Thr Pro Lys Met Ser Ala Gly
                2965                2970                2975    
Gln Met Leu Leu Val Ala Phe Asp Gly Met Phe Ala Gln Val Glu Thr
            2980                2985                2990        
Ala Phe Ser Leu Leu Val Glu Lys Leu Asn Lys Met Glu Ile Pro Ile
        2995                3000                3005            
Ala Trp Arg Lys Ile Asp Ile Ile Arg Glu Ala Arg Ser Thr Gln Val
    3010                3015                3020                
Asn Phe Phe Asp Asp Asp Asn His Arg Gln Val Leu Glu Glu Ile Phe
3025                3030                3035                3040
Phe Leu Lys Arg Leu Gln Thr Ile Lys Glu Phe Phe Arg Leu Cys Gly
                3045                3050                3055    
Thr Phe Ser Lys Thr Leu Ser Gly Ser Ser Ser Leu Glu Asp Gln Asn
            3060                3065                3070        
Thr Val Asn Gly Pro Val Gln Ile Val Asn Val Lys Thr Leu Phe Arg
        3075                3080                3085            
Asn Ser Cys Phe Ser Glu Asp Gln Met Ala Lys Pro Ile Lys Ala Phe
    3090                3095                3100                
Thr Ala Asp Phe Val Arg Gln Leu Leu Ile Gly Leu Pro Asn Gln Ala
3105                3110                3115                3120
Leu Gly Leu Thr Leu Cys Ser Phe Ile Ser Ala Leu Gly Val Asp Ile
                3125                3130                3135    
Ile Ala Gln Val Glu Ala Lys Asp Phe Gly Ala Glu Ser Lys Val Ser
            3140                3145                3150        
Val Asp Asp Leu Cys Lys Lys Ala Val Glu His Asn Ile Gln Ile Gly
        3155                3160                3165            
Lys Phe Ser Gln Leu Val Met Asn Arg Ala Thr Val Leu Ala Ser Ser
    3170                3175                3180                
Tyr Asp Thr Ala Trp Lys Lys His Asp Leu Val Arg Arg Leu Glu Thr
3185                3190                3195                3200
Ser Ile Ser Ser Cys Lys Thr Ser Leu Gln Arg Val Gln Leu His Ile
                3205                3210                3215    
Ala Met Phe Gln Trp Gln His Glu Asp Leu Leu Ile Asn Arg Pro Gln
            3220                3225                3230        
Ala Met Ser Val Thr Pro Pro Pro Arg Ser Ala Ile Leu Thr Ser Met
        3235                3240                3245            
Lys Lys Lys Leu His Thr Leu Ser Gln Ile Glu Thr Ser Ile Ala Thr
    3250                3255                3260                
Val Gln Glu Lys Leu Ala Ala Leu Glu Ser Ser Ile Glu Gln Arg Leu
3265                3270                3275                3280
Lys Trp Ala Gly Gly Ala Asn Pro Ala Leu Ala Pro Val Leu Gln Asp
                3285                3290                3295    
Phe Glu Ala Thr Ile Ala Glu Arg Arg Asn Leu Val Leu Lys Glu Ser
            3300                3305                3310        
Gln Arg Ala Ser Gln Val Thr Phe Leu Cys Ser Asn Ile Ile His Phe
        3315                3320                3325            
Glu Ser Leu Arg Thr Arg Thr Ala Glu Ala Leu Asn Leu Asp Ala Ala
    3330                3335                3340                
Leu Phe Glu Leu Ile Lys Arg Cys Gln Gln Met Cys Ser Phe Ala Ser
3345                3350                3355                3360
Gln Phe Asn Ser Ser Val Ser Glu Leu Glu Leu Arg Leu Leu Gln Arg
                3365                3370                3375    
Val Asp Thr Gly Leu Glu His Pro Ile Gly Ser Ser Glu Trp Leu Leu
            3380                3385                3390        
Ser Ala His Lys Gln Leu Thr Gln Asp Met Ser Thr Gln Arg Ala Ile
        3395                3400                3405            
Gln Thr Glu Lys Glu Gln Gln Ile Glu Thr Val Cys Glu Thr Ile Gln
    3410                3415                3420                
Asn Leu Val Asp Asn Ile Lys Thr Val Leu Thr Gly His Asn Arg Gln
3425                3430                3435                3440
Leu Gly Asp Val Lys His Leu Leu Lys Ala Met Ala Lys Asp Glu Glu
                3445                3450                3455    
Ala Ala Leu Ala Asp Gly Glu Asp Val Pro Tyr Glu Asn Ser Val Arg
            3460                3465                3470        
Gln Phe Leu Gly Glu Tyr Lys Ser Trp Gln Asp Asn Ile Gln Thr Val
        3475                3480                3485            
Leu Phe Thr Leu Val Gln Ala Met Gly Gln Val Arg Ser Gln Glu His
    3490                3495                3500                
Val Glu Met Leu Gln Glu Ile Thr Pro Thr Leu Lys Glu Leu Lys Thr
3505                3510                3515                3520
Gln Ser Gln Ser Ile Tyr Asn Asn Leu Val Ser Phe Ala Ser Pro Leu
                3525                3530                3535    
Val Thr Asp Ala Thr Asn Glu Cys Ser Ser Pro Thr Ser Ser Ala Thr
            3540                3545                3550        
Tyr Gln Pro Ser Phe Ala Ala Ala Val Arg Ser Asn Thr Gly Gln Lys
        3555                3560                3565            
Thr Gln Pro Asp Val Met Ser Gln Asn Ala Arg Lys Leu Ile Gln Lys
    3570                3575                3580                
Asn Leu Ala Thr Ser Ala Asp Thr Pro Pro Ser Thr Val Pro Gly Thr
3585                3590                3595                3600
Gly Lys Ser Val Ala Cys Ser Pro Lys Lys Ala Val Arg Asp Pro Lys
                3605                3610                3615    
Thr Gly Lys Ala Val Gln Glu Arg Asn Ser Tyr Ala Val Ser Val Trp
            3620                3625                3630        
Lys Arg Val Lys Ala Lys Leu Glu Gly Arg Asp Val Asp Pro Asn Arg
        3635                3640                3645            
Arg Met Ser Val Ala Glu Gln Val Asp Tyr Val Ile Lys Glu Ala Thr
    3650                3655                3660                
Asn Leu Asp Asn Leu Ala Gln Leu Tyr Glu Gly Trp Thr Ala Trp Val
3665                3670                3675                3680


<210> 8860
<211> 587
<212> PRT
<213> Homo sapiens

<400> 8860
Val Arg Pro Leu Leu Leu Cys Ser Ser Lys Lys Ala Arg Ala Ala Leu
 1               5                  10                  15      
Pro Gln Val Leu Thr Phe Ser Gln Arg Arg Arg Ala Arg Ala Leu Ser
            20                  25                  30          
Gly Arg Arg Leu Arg Arg Arg Pro Thr Leu Gln Ser Pro Leu Val Ala
        35                  40                  45              
Pro Arg Pro Ser Arg Cys Pro Glu Ser Gly Gly His Glu Ala Gln Pro
    50                  55                  60                  
Arg Pro Pro Ala Leu Ala Arg Pro Ala Ala Ala Ala Met Ser Arg Gly
65                  70                  75                  80  
Pro Glu Glu Val Asn Arg Leu Thr Glu Ser Thr Tyr Arg Asn Val Met
                85                  90                  95      
Glu Gln Phe Asn Pro Gly Leu Arg Asn Leu Ile Asn Leu Gly Lys Asn
            100                 105                 110         
Tyr Glu Lys Ala Val Asn Ala Met Ile Leu Ala Gly Lys Ala Tyr Tyr
        115                 120                 125             
Asp Gly Val Ala Lys Ile Gly Glu Ile Ala Thr Gly Ser Pro Val Ser
    130                 135                 140                 
Thr Glu Leu Gly His Val Leu Ile Glu Ile Ser Ser Thr His Lys Lys
145                 150                 155                 160 
Leu Asn Glu Ser Leu Asp Glu Asn Phe Lys Lys Phe His Lys Glu Ile
                165                 170                 175     
Ile His Glu Leu Glu Lys Lys Ile Glu Leu Asp Val Lys Tyr Met Asn
            180                 185                 190         
Ala Thr Leu Lys Arg Tyr Gln Thr Glu His Lys Asn Lys Leu Glu Ser
        195                 200                 205             
Leu Glu Lys Ser Gln Ala Glu Leu Lys Lys Ile Arg Arg Lys Ser Gln
    210                 215                 220                 
Gly Ser Arg Asn Ala Leu Lys Tyr Glu His Lys Glu Ile Glu Tyr Val
225                 230                 235                 240 
Glu Thr Val Thr Ser Arg Gln Ser Glu Ile Gln Lys Phe Ile Ala Asp
                245                 250                 255     
Gly Cys Lys Glu Ala Leu Leu Glu Glu Lys Arg Arg Phe Cys Phe Leu
            260                 265                 270         
Val Asp Lys His Cys Gly Phe Ala Asn His Ile His Tyr Tyr His Leu
        275                 280                 285             
Gln Ser Ala Glu Leu Leu Asn Ser Lys Leu Pro Arg Trp Gln Glu Thr
    290                 295                 300                 
Cys Val Asp Ala Ile Lys Val Pro Glu Lys Ile Met Asn Met Ile Glu
305                 310                 315                 320 
Glu Ile Lys Thr Pro Ala Ser Thr Pro Val Ser Gly Thr Pro Gln Ala
                325                 330                 335     
Ser Pro Met Ile Glu Arg Ser Asn Val Val Arg Lys Asp Tyr Asp Thr
            340                 345                 350         
Leu Ser Lys Cys Ser Pro Lys Met Pro Pro Ala Pro Ser Gly Arg Ala
        355                 360                 365             
Tyr Thr Ser Pro Leu Ile Asp Met Phe Asn Asn Pro Ala Thr Ala Ala
    370                 375                 380                 
Pro Asn Ser Gln Arg Val Asn Asn Ser Thr Gly Thr Ser Glu Asp Pro
385                 390                 395                 400 
Ser Leu Gln Arg Ser Val Ser Val Ala Thr Gly Leu Asn Met Met Lys
                405                 410                 415     
Lys Gln Lys Val Lys Thr Ile Phe Pro His Thr Ala Gly Ser Asn Lys
            420                 425                 430         
Thr Leu Leu Ser Phe Ala Gln Gly Asp Val Ile Thr Leu Leu Ile Pro
        435                 440                 445             
Glu Glu Lys Asp Gly Trp Leu Tyr Gly Glu His Asp Val Ser Lys Ala
    450                 455                 460                 
Arg Gly Trp Phe Pro Ser Ser Tyr Thr Lys Leu Leu Glu Glu Asn Glu
465                 470                 475                 480 
Thr Glu Ala Val Thr Val Pro Thr Pro Ser Pro Thr Pro Val Arg Ser
                485                 490                 495     
Ile Ser Thr Val Asn Leu Ser Glu Asn Ser Ser Val Val Ile Pro Pro
            500                 505                 510         
Pro Asp Tyr Leu Glu Cys Leu Ser Met Gly Ala Ala Ala Asp Arg Arg
        515                 520                 525             
Ala Asp Ser Ala Arg Thr Thr Ser Thr Phe Lys Ala Pro Ala Ser Lys
    530                 535                 540                 
Pro Glu Thr Ala Ala Pro Asn Asp Ala Asn Gly Thr Ala Lys Pro Pro
545                 550                 555                 560 
Phe Leu Ser Gly Glu Asn Pro Phe Ala Thr Val Lys Leu Arg Pro Thr
                565                 570                 575     
Val Thr Asn Asp Arg Ser Ala Pro Ile Ile Arg
            580                 585         


<210> 8861
<211> 1268
<212> PRT
<213> Homo sapiens

<400> 8861
Met Ser Ala Pro Ala Gly Ser Ser His Pro Ala Ala Ser Ala Arg Ile
 1               5                  10                  15      
Pro Pro Lys Phe Gly Gly Ser Ala Val Ser Gly Ala Ala Ala Pro Ala
            20                  25                  30          
Gly Pro Gly Ala Gly Pro Ala Pro His Gln Gln Asn Gly Pro Ala Gln
        35                  40                  45              
Asn Gln Met Gln Val Pro Ser Gly Tyr Gly Leu His His Gln Asn Tyr
    50                  55                  60                  
Ile Ala Pro Ser Gly His Tyr Ser Gln Gly Pro Gly Lys Met Thr Ser
65                  70                  75                  80  
Leu Pro Leu Asp Thr Gln Cys Gly Asp Tyr Tyr Ser Ala Leu Tyr Thr
                85                  90                  95      
Val Pro Thr Gln Asn Val Thr Pro Asn Thr Val Asn Gln Gln Pro Gly
            100                 105                 110         
Ala Gln Gln Leu Tyr Ser Arg Gly Pro Pro Ala Pro His Ile Val Gly
        115                 120                 125             
Ser Thr Leu Gly Ser Phe Gln Gly Ala Ala Ser Ser Ala Ser His Leu
    130                 135                 140                 
His Thr Ser Ala Ser Gln Pro Tyr Ser Ser Phe Val Asn His Tyr Asn
145                 150                 155                 160 
Ser Pro Ala Met Tyr Ser Ala Ser Ser Ser Val Ala Ser Gln Gly Phe
                165                 170                 175     
Pro Ser Thr Cys Gly His Tyr Ala Met Ser Thr Val Ser Asn Ala Ala
            180                 185                 190         
Tyr Pro Ser Val Ser Tyr Pro Ser Leu Pro Ala Gly Asp Thr Tyr Gly
        195                 200                 205             
Gln Met Phe Thr Ser Gln Asn Ala Pro Thr Val Arg Pro Val Lys Asp
    210                 215                 220                 
Asn Ser Phe Ser Gly Gln Asn Thr Ala Ile Ser His Pro Ser Pro Leu
225                 230                 235                 240 
Pro Pro Leu Pro Ser Gln Gln His His Gln Gln Gln Ser Leu Ser Gly
                245                 250                 255     
Tyr Ser Thr Leu Thr Trp Ser Ser Pro Gly Leu Pro Ser Thr Gln Asp
            260                 265                 270         
Asn Leu Ile Arg Asn His Thr Gly Ser Leu Ala Val Ala Asn Asn Asn
        275                 280                 285             
Pro Thr Ile Thr Val Ala Asp Ser Leu Ser Cys Pro Val Met Gln Asn
    290                 295                 300                 
Val Gln Pro Pro Lys Ser Ser Pro Val Val Ser Thr Val Leu Ser Gly
305                 310                 315                 320 
Ser Ser Gly Ser Ser Ser Thr Arg Thr Pro Pro Thr Ala Asn His Pro
                325                 330                 335     
Val Glu Pro Val Thr Ser Val Thr Gln Pro Ser Glu Leu Leu Gln Gln
            340                 345                 350         
Lys Gly Val Gln Tyr Gly Glu Tyr Val Asn Asn Gln Ala Ser Ser Ala
        355                 360                 365             
Pro Thr Pro Leu Ser Ser Thr Ser Asp Asp Glu Glu Glu Glu Glu Glu
    370                 375                 380                 
Asp Glu Glu Ala Gly Val Asp Ser Ser Ser Thr Thr Ser Ser Ala Ser
385                 390                 395                 400 
Pro Met Pro Asn Ser Tyr Asp Ala Leu Glu Gly Gly Ser Tyr Pro Asp
                405                 410                 415     
Met Leu Ser Ser Ser Ala Ser Ser Pro Ala Pro Asp Pro Ala Pro Glu
            420                 425                 430         
Pro Asp Pro Ala Ser Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Val
        435                 440                 445             
Val Pro Gln Pro Ser Lys Met Ala Lys Pro Leu Ala Met Ala Ile Gln
    450                 455                 460                 
His Phe Ser Leu Val Ile Arg Met Leu Gln His His Leu Phe Leu Glu
465                 470                 475                 480 
Tyr Ser Pro Ser Asn Pro Val Tyr Ser Gly Phe Gln Gln Tyr Pro Gln
                485                 490                 495     
Gln Tyr Pro Gly Val Asn Gln Leu Ser Ser Ser Ile Gly Gly Leu Ser
            500                 505                 510         
Leu Gln Ser Ser Pro Gln Pro Glu Ser Leu Arg Pro Val Asn Leu Thr
        515                 520                 525             
Gln Glu Arg Asn Ile Leu Pro Met Thr Pro Val Trp Ala Pro Val Pro
    530                 535                 540                 
Asn Leu Asn Ala Asp Leu Lys Lys Leu Asn Cys Ser Pro Asp Ser Phe
545                 550                 555                 560 
Arg Cys Thr Leu Thr Asn Ile Pro Gln Thr Gln Ala Leu Leu Asn Lys
                565                 570                 575     
Ala Lys Leu Pro Leu Gly Leu Leu Leu His Pro Phe Arg Asp Leu Thr
            580                 585                 590         
Gln Leu Pro Val Ile Thr Ser Asn Thr Ile Val Arg Cys Arg Ser Cys
        595                 600                 605             
Arg Thr Tyr Ile Asn Pro Phe Val Ser Phe Ile Asp Gln Arg Arg Trp
    610                 615                 620                 
Lys Cys Asn Leu Cys Tyr Arg Val Asn Asp Val Pro Glu Glu Phe Met
625                 630                 635                 640 
Tyr Asn Pro Leu Thr Arg Ser Tyr Gly Glu Pro His Lys Arg Pro Glu
                645                 650                 655     
Val Gln Asn Ser Thr Val Glu Phe Ile Ala Ser Ser Asp Tyr Met Leu
            660                 665                 670         
Arg Pro Pro Gln Pro Ala Val Tyr Leu Phe Val Leu Asp Val Ser His
        675                 680                 685             
Asn Ala Val Glu Ala Gly Tyr Leu Thr Ile Leu Cys Gln Ser Leu Leu
    690                 695                 700                 
Glu Asn Leu Asp Lys Leu Pro Gly Asp Ser Arg Thr Arg Ile Gly Phe
705                 710                 715                 720 
Met Thr Phe Asp Ser Thr Ile His Phe Tyr Asn Leu Gln Glu Gly Leu
                725                 730                 735     
Ser Gln Pro Gln Met Leu Ile Val Ser Asp Ile Asp Asp Val Phe Leu
            740                 745                 750         
Pro Thr Pro Asp Ser Leu Leu Val Asn Leu Tyr Glu Ser Lys Glu Leu
        755                 760                 765             
Ile Lys Asp Leu Leu Asn Ala Leu Pro Asn Met Phe Thr Asn Thr Arg
    770                 775                 780                 
Glu Thr His Ser Ala Leu Gly Pro Ala Leu Gln Ala Ala Phe Lys Leu
785                 790                 795                 800 
Met Ser Pro Thr Gly Gly Arg Val Ser Val Phe Gln Thr Gln Leu Pro
                805                 810                 815     
Ser Leu Gly Ala Gly Leu Leu Gln Ser Arg Glu Asp Pro Asn Gln Arg
            820                 825                 830         
Ser Ser Thr Lys Val Val Gln His Leu Gly Pro Ala Thr Asp Phe Tyr
        835                 840                 845             
Lys Lys Leu Ala Leu Asp Cys Ser Gly Gln Gln Thr Ala Val Asp Leu
    850                 855                 860                 
Phe Leu Leu Ser Ser Gln Tyr Ser Asp Leu Ala Ser Leu Ala Cys Met
865                 870                 875                 880 
Ser Lys Tyr Ser Ala Gly Cys Ile Tyr Tyr Tyr Pro Ser Phe His Tyr
                885                 890                 895     
Thr His Asn Pro Ser Gln Ala Glu Lys Leu Gln Lys Asp Leu Lys Arg
            900                 905                 910         
Tyr Leu Thr Arg Lys Ile Gly Phe Glu Ala Val Met Arg Ile Arg Cys
        915                 920                 925             
Thr Lys Gly Leu Ser Met His Thr Phe His Gly Asn Phe Phe Val Arg
    930                 935                 940                 
Ser Thr Asp Leu Leu Ser Leu Ala Asn Ile Asn Pro Asp Ala Gly Phe
945                 950                 955                 960 
Ala Val Gln Leu Ser Ile Glu Glu Ser Leu Thr Asp Thr Ser Leu Val
                965                 970                 975     
Cys Phe Gln Thr Ala Leu Leu Tyr Thr Ser Ser Lys Gly Glu Arg Arg
            980                 985                 990         
Ile Arg Val His Thr Leu Cys Leu Pro Val Val Ser Ser Leu Ala Asp
        995                 1000                1005            
Val Tyr Ala Gly Val Asp Val Gln Ala Ala Ile Cys Leu Leu Ala Asn
    1010                1015                1020                
Met Ala Val Asp Arg Ser Val Ser Ser Ser Leu Ser Asp Ala Arg Asp
1025                1030                1035                1040
Ala Leu Val Asn Ala Val Val Asp Ser Leu Ser Ala Tyr Gly Ser Thr
                1045                1050                1055    
Val Ser Asn Leu Gln His Ser Ala Leu Met Ala Pro Ser Ser Leu Lys
            1060                1065                1070        
Leu Phe Pro Leu Tyr Val Leu Ala Leu Leu Lys Gln Lys Ala Phe Arg
        1075                1080                1085            
Thr Gly Thr Ser Thr Arg Leu Asp Asp Arg Val Tyr Ala Met Cys Gln
    1090                1095                1100                
Ile Lys Ser Gln Pro Leu Val His Leu Met Lys Met Ile His Pro Asn
1105                1110                1115                1120
Leu Tyr Arg Ile Asp Arg Leu Thr Asp Glu Gly Ala Val His Val Asn
                1125                1130                1135    
Asp Arg Ile Val Pro Gln Pro Pro Leu Gln Lys Leu Ser Ala Glu Lys
            1140                1145                1150        
Leu Thr Arg Glu Gly Ala Phe Leu Met Asp Cys Gly Ser Val Phe Tyr
        1155                1160                1165            
Ile Trp Val Gly Lys Gly Cys Asp Asn Asn Phe Ile Glu Asp Val Leu
    1170                1175                1180                
Gly Tyr Thr Asn Phe Ala Ser Ile Pro Gln Lys Met Thr His Leu Pro
1185                1190                1195                1200
Glu Leu Asp Thr Leu Ser Ser Glu Arg Ala Arg Ser Phe Ile Thr Trp
                1205                1210                1215    
Leu Arg Asp Ser Arg Pro Leu Ser Pro Ile Leu His Ile Val Lys Asp
            1220                1225                1230        
Glu Ser Pro Ala Lys Ala Glu Phe Phe Gln His Leu Ile Glu Asp Arg
        1235                1240                1245            
Thr Glu Ala Ala Phe Ser Tyr Tyr Glu Phe Leu Leu His Val Gln Gln
    1250                1255                1260                
Gln Ile Cys Lys
1265            


<210> 8862
<211> 552
<212> PRT
<213> Homo sapiens

<400> 8862
Met Thr Ile Lys Gly Lys Pro Pro Cys Val Pro Ser Ser Ser Tyr Gly
 1               5                  10                  15      
Leu Val Glu Ala Leu Leu Thr Val Ser Val Gly Thr Ser Ser Ser Ala
            20                  25                  30          
Leu Thr Leu Leu Ile Leu Leu Gln Val Ala Glu Ser Arg Leu Pro Pro
        35                  40                  45              
Arg Pro Arg His Arg Gly Pro Gly Gln Arg Leu Glu Ala Ala Arg Pro
    50                  55                  60                  
Cys Ala Ala Leu Ser Pro Glu Pro Ala Glu Pro Ala Ala Pro Gly Leu
65                  70                  75                  80  
Gly Ala Thr Met Leu Glu Ser Ile Arg Val Thr Glu Lys Leu His Trp
                85                  90                  95      
Pro Glu Gln Glu Leu Ala Lys Lys Ser Ile Leu Asn Ala Glu Asp Ser
            100                 105                 110         
Leu Ile Ile Asp Asn Lys Arg Ser Ile Ser His Leu Ser Ser Gly Val
        115                 120                 125             
Leu Lys Asp Ile Phe Thr Thr Gly Thr Ser Ser Tyr Asn Val Leu Leu
    130                 135                 140                 
Gln Ser Lys Glu Glu Lys Lys Tyr His Ser Gln Lys Gln Ser Ser Ser
145                 150                 155                 160 
Thr Tyr Ser Lys Arg Cys Arg Lys Pro Ser Lys Ser Pro Asn Thr Ser
                165                 170                 175     
Arg Ser Lys Asp Pro Arg Arg Met Lys Ala Leu Val Pro Val Thr Ser
            180                 185                 190         
Ser Gly Thr Trp Tyr Cys Leu Glu Arg Arg Pro Ala Val Phe Val Thr
        195                 200                 205             
Ser Ser Val Ser Ser Pro Val Lys Phe Thr His Asp Ile Ser Val Thr
    210                 215                 220                 
Gly Asn Gly Ile Val Leu Pro Pro Lys Pro Lys Ser Lys Val Lys Trp
225                 230                 235                 240 
Cys His Phe Ser Thr Leu Pro Lys Pro Lys Pro Gln Leu Ser Arg Ser
                245                 250                 255     
Phe Glu Lys Gly Asp Asp Phe Ser Gly Lys Lys Phe Cys Ile Leu Thr
            260                 265                 270         
Ala Ile Lys Pro Thr Asn Leu Glu Lys Glu Lys Leu Arg Phe Phe Lys
        275                 280                 285             
Ser Asp Tyr Thr Tyr Asn Pro Gln Phe Glu Tyr Ala Asn Pro Ala Leu
    290                 295                 300                 
Pro Ser Val Leu Ala Lys His Ser His Ala Ser Asp Arg Phe Leu Lys
305                 310                 315                 320 
Gln Ile Val Val His Leu Thr Glu Asp Leu Leu Ser Arg Ala Ser Met
                325                 330                 335     
Thr Val Val Asn Gly Cys Pro Thr Leu Thr Ile Asn Val Ser Thr Ala
            340                 345                 350         
Arg Glu His Trp Leu Glu Gly Met Leu Arg His Glu Ile Gly Thr His
        355                 360                 365             
Tyr Phe Arg Gly Ile Asn Asn Leu Gln Gln Pro Trp Asn Ser Trp Thr
    370                 375                 380                 
Gly Arg Lys Lys His Glu Leu Lys Pro Asn Asn Pro Thr Glu Glu Gly
385                 390                 395                 400 
Leu Ala Ser Ile His Ser Val Leu Phe Arg Lys Asp Pro Phe Leu Trp
                405                 410                 415     
Arg Ala Ala Leu Leu Tyr Tyr Thr Val Tyr Gln Ala Ser Gln Met Ser
            420                 425                 430         
Phe Cys Glu Leu Phe Lys Asp Ile Gly Arg Phe Val Lys Asp Pro Asn
        435                 440                 445             
Thr Arg Trp Asp Tyr Cys Val Arg Ala Lys Arg Gly Trp Thr Asp Thr
    450                 455                 460                 
Ser Gln Pro Gly Cys Phe Ser Lys Asp Gln Val Tyr Leu Asp Gly Ile
465                 470                 475                 480 
Leu Gln Ile Leu Arg Tyr Arg Asp Thr Ile Asp Phe His Leu Leu Thr
                485                 490                 495     
Ala Leu Gly Lys Val Ser Tyr Glu Asp Val Asp Arg Leu Lys Gly Leu
            500                 505                 510         
Ala Val Thr Glu Asn Met Arg Val Pro His Phe Leu Gln Asp His Gly
        515                 520                 525             
Arg Tyr Met Glu His Leu Glu Lys Ile Met Glu Val Asn Glu Leu Thr
    530                 535                 540                 
Asp Arg Glu Leu Lys Asp Leu Ile
545                 550         


<210> 8863
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8863
Val Pro Gly Arg Ala Gly Arg Gly Gly Gly Ala Gly Arg Thr Gly Val
 1               5                  10                  15      
Pro Pro Pro Gly Ala Gln Val Met Val Ala Thr Gly Trp Ala Arg Arg
            20                  25                  30          
Ser Gly Leu His Pro Ala Pro Arg Pro Leu Arg Gly Ala Gln Glu Ala
        35                  40                  45              
Leu Ala Lys Asn Leu Trp Arg Glu Glu Arg Asn Arg Pro Leu Ile Leu
    50                  55                  60                  
Ser Ser Leu Ile Ile Lys Lys Leu His Trp Pro Glu Gln Glu Leu Ala
65                  70                  75                  80  
Lys Lys Ser Ile Leu Asn Ala Glu Asp Ser Leu Ile Ile Asp Asn Lys
                85                  90                  95      
Arg Ser Ile Ser His Leu Ser Ser Gly Val Leu Lys Asp Ile Phe Thr
            100                 105                 110         
Thr Gly Thr Ser Ser Tyr Asn Val Leu Leu Gln Ser Lys Glu Glu Lys
        115                 120                 125             
Lys Tyr His Ser Gln Lys Gln Ser Ser Ser Thr Tyr Ser Lys Arg Cys
    130                 135                 140                 
Arg Lys Pro Ser Lys Ser Pro Asn Thr Ser Arg Ser Lys Asp Pro Arg
145                 150                 155                 160 
Arg Met Lys Ala Leu Val Pro Val Thr Ser Ser Gly Thr Trp Tyr Cys
                165                 170                 175     
Leu Glu Arg Arg Pro Ala Val Phe Val Thr Ser Ser Val Ser Ser Pro
            180                 185                 190         
Val Lys Phe Thr His Asp Ile Ser Val Thr Gly Asn Gly Ile Val Leu
        195                 200                 205             
Pro Pro Lys Pro Lys Ser Lys Val Lys Trp Cys His Phe Ser Thr Leu
    210                 215                 220                 
Pro Lys Pro Lys Pro Gln Leu Ser Arg Ser Phe Glu Lys Gly Asp Asp
225                 230                 235                 240 
Phe Ser Gly Lys Lys Phe Cys Ile Leu Thr Ala Ile Lys Pro Thr Asn
                245                 250                 255     
Leu Glu Lys Glu Lys Leu Arg Phe Phe Lys Ser Asp Tyr Thr Tyr Asn
            260                 265                 270         
Pro Gln Phe Glu Tyr Ala Asn Pro Ala Leu Pro Ser Val Leu Ala Lys
        275                 280                 285             
His Ser His Ala Ser Asp Arg Phe Leu Lys Gln Ile Val Val His Leu
    290                 295                 300                 
Thr Glu Asp Leu Leu Ser Arg Ala Ser Met Thr Val Val Asn Gly Cys
305                 310                 315                 320 
Pro Thr Leu Thr Ile Asn Val Ser Thr Ala Arg Glu His Trp Leu Glu
                325                 330                 335     
Gly Met Leu Arg His Glu Ile Gly Thr His Tyr Phe Arg Gly Ile Asn
            340                 345                 350         
Asn Leu Gln Gln Pro Trp Asn Ser Trp Thr Gly Arg Lys Lys His Glu
        355                 360                 365             
Leu Lys Pro Asn Asn Pro Thr Glu Glu Gly Leu Ala Ser Ile His Ser
    370                 375                 380                 
Val Leu Phe Arg Lys Asp Pro Phe Leu Trp Arg Ala Ala Leu Leu Tyr
385                 390                 395                 400 
Tyr Thr Val Tyr Gln Ala Ser Gln Met Ser Phe Cys Glu Leu Phe Lys
                405                 410                 415     
Asp Ile Gly Arg Phe Val Lys Asp Pro Asn Thr Arg Trp Asp Tyr Cys
            420                 425                 430         
Val Arg Ala Lys Arg Gly Trp Thr Asp Thr Ser Gln Pro Gly Cys Phe
        435                 440                 445             
Ser Lys Asp Gln Val Tyr Leu Asp Gly Ile Leu Gln Ile Leu Arg Tyr
    450                 455                 460                 
Arg Asp Thr Ile Asp Phe His Leu Leu Thr Ala Leu Gly Lys Val Ser
465                 470                 475                 480 
Tyr Glu Asp Val Asp Arg Leu Lys Gly Leu Ala Val Thr Glu Asn Met
                485                 490                 495     
Arg Val Pro His Phe Leu Gln Asp His Gly Arg Tyr Met Glu His Leu
            500                 505                 510         
Glu Lys Ile Met Glu Val Asn Glu Leu Thr Asp Arg Glu Leu Lys Asp
        515                 520                 525             
Leu Ile
    530 


<210> 8864
<211> 525
<212> PRT
<213> Homo sapiens

<400> 8864
Ser Gly Glu Arg Trp Val Met Ala Gly Cys Thr Arg Lys Leu Thr His
 1               5                  10                  15      
Leu Arg Lys Arg Ile His Arg Pro Arg Arg Arg Thr Thr Arg Arg Trp
            20                  25                  30          
Lys Arg Trp Phe Lys Phe Arg Lys Arg Lys Gly Glu Lys Arg Pro Arg
        35                  40                  45              
Pro Asn His Lys Ala Val Ala Arg Arg Ala Lys Leu Lys Phe Ser Thr
    50                  55                  60                  
Ser Glu Lys Leu His Trp Pro Glu Gln Glu Leu Ala Lys Lys Ser Ile
65                  70                  75                  80  
Leu Asn Ala Glu Asp Ser Leu Ile Ile Asp Asn Lys Arg Ser Ile Ser
                85                  90                  95      
His Leu Ser Ser Gly Val Leu Lys Asp Ile Phe Thr Thr Gly Thr Ser
            100                 105                 110         
Ser Tyr Asn Val Leu Leu Gln Ser Lys Glu Glu Lys Lys Tyr His Ser
        115                 120                 125             
Gln Lys Gln Ser Ser Ser Thr Tyr Ser Lys Arg Cys Arg Lys Pro Ser
    130                 135                 140                 
Lys Ser Pro Asn Thr Ser Arg Ser Lys Asp Pro Arg Arg Met Lys Ala
145                 150                 155                 160 
Leu Val Pro Val Thr Ser Ser Gly Thr Trp Tyr Cys Leu Glu Arg Arg
                165                 170                 175     
Pro Ala Val Phe Val Thr Ser Ser Val Ser Ser Pro Val Lys Phe Thr
            180                 185                 190         
His Asp Ile Ser Val Thr Gly Asn Gly Ile Val Leu Pro Pro Lys Pro
        195                 200                 205             
Lys Ser Lys Val Lys Trp Cys His Phe Ser Thr Leu Pro Lys Pro Lys
    210                 215                 220                 
Pro Gln Leu Ser Arg Ser Phe Glu Lys Gly Asp Asp Phe Ser Gly Lys
225                 230                 235                 240 
Lys Phe Cys Ile Leu Thr Ala Ile Lys Pro Thr Asn Leu Glu Lys Glu
                245                 250                 255     
Lys Leu Arg Phe Phe Lys Ser Asp Tyr Thr Tyr Asn Pro Gln Phe Glu
            260                 265                 270         
Tyr Ala Asn Pro Ala Leu Pro Ser Val Leu Ala Lys His Ser Pro Ser
        275                 280                 285             
Asp Arg Phe Leu Lys Gln Ile Val Val His Leu Thr Glu Asp Leu Leu
    290                 295                 300                 
Ser Arg Ala Ser Met Thr Val Val Asn Gly Cys Pro Thr Leu Thr Ile
305                 310                 315                 320 
Asn Val Ser Thr Ala Arg Glu His Trp Leu Glu Gly Met Leu Arg His
                325                 330                 335     
Glu Ile Gly Thr His Tyr Phe Arg Gly Ile Asn Asn Leu Gln Gln Pro
            340                 345                 350         
Trp Asn Ser Trp Thr Gly Arg Lys Lys His Glu Leu Lys Pro Asn Asn
        355                 360                 365             
Pro Thr Glu Glu Gly Leu Ala Ser Ile His Ser Val Leu Phe Arg Lys
    370                 375                 380                 
Asp Pro Phe Leu Trp Arg Ala Ala Leu Leu Tyr Tyr Thr Val Tyr Gln
385                 390                 395                 400 
Ala Ser Gln Met Ser Phe Cys Glu Leu Phe Lys Asp Ile Gly Arg Phe
                405                 410                 415     
Val Lys Asp Pro Asn Thr Arg Trp Asp Tyr Cys Val Arg Ala Lys Arg
            420                 425                 430         
Gly Trp Thr Asp Thr Ser Gln Pro Gly Cys Phe Ser Lys Asp Gln Val
        435                 440                 445             
Tyr Leu Asp Gly Ile Leu Gln Ile Leu Arg Tyr Arg Asp Thr Ile Asp
    450                 455                 460                 
Phe His Leu Leu Thr Ala Leu Gly Lys Val Ser Tyr Glu Asp Val Asp
465                 470                 475                 480 
Arg Leu Lys Gly Leu Ala Val Thr Glu Asn Met Arg Val Pro His Phe
                485                 490                 495     
Leu Gln Asp His Gly Arg Tyr Met Glu His Leu Glu Lys Ile Met Glu
            500                 505                 510         
Val Asn Glu Leu Thr Asp Arg Glu Leu Lys Asp Leu Ile
        515                 520                 525 


<210> 8865
<211> 673
<212> PRT
<213> Homo sapiens

<400> 8865
Met Ser Arg Thr Leu Ala Ser Ala Val Leu Leu Ser Ser Pro Asp Tyr
 1               5                  10                  15      
Tyr Glu Arg Leu Gly Gln Leu Gln His Gly Leu Arg Asp Ser Glu Lys
            20                  25                  30          
Lys Arg Leu Asp Leu Glu Lys Lys Leu Tyr Glu Tyr Asn Gln Ser Asp
        35                  40                  45              
Thr Cys Arg Val Lys Leu Lys Tyr Val Lys Leu Lys Asn Tyr Leu Lys
    50                  55                  60                  
Glu Ile Cys Glu Ser Glu Lys Lys Ala His Thr Arg Asn Gln Glu Tyr
65                  70                  75                  80  
Leu Lys Arg Phe Glu Arg Val Gln Ala His Val Val His Phe Thr Thr
                85                  90                  95      
Asn Thr Glu Lys Leu Gln Lys Leu Lys Leu Glu Tyr Glu Thr Gln Ile
            100                 105                 110         
Lys Lys Met Leu Cys Ser Lys Asp Ser Leu Gly Leu Lys Glu Glu Leu
        115                 120                 125             
Thr Asp Glu Asp Arg Glu Lys Val Ala Val His Glu Gly Ile Asn Ser
    130                 135                 140                 
Gly Thr Ala Met Ser Arg Gly Leu Tyr Gln Pro Ala Thr Ile Phe Met
145                 150                 155                 160 
Gly Arg Gln Met Ser Ala Ile Leu Ser Met Arg Asp Phe Ser Thr Glu
                165                 170                 175     
His Lys Ser Pro Gln Pro Thr Lys Asn Phe Ser Ile Pro Asp Pro His
            180                 185                 190         
Ser His Arg Gln Thr Ala Gln Ser Ser Asn Val Thr Asp Ser Cys Val
        195                 200                 205             
Val Gln Thr Ser Asn Asp Thr Gln Cys Leu Asn Lys Ser Asp Asn Ile
    210                 215                 220                 
Asp Gly Lys Ala Ser Leu Gln Ile Gly Glu Lys Met Pro Val Thr Ala
225                 230                 235                 240 
Ser Val Leu Ser Glu Glu Glu Gln Thr His Cys Leu Glu Ile Gly Ser
                245                 250                 255     
Asn Thr Arg His Gly Lys Ser Asn Leu Ser Glu Gly Lys Lys Ser Ala
            260                 265                 270         
Glu Leu Asn Ser Pro Leu Arg Glu Arg Leu Ser Pro Glu Asn Arg Thr
        275                 280                 285             
Thr Asp Leu Lys Cys Asp Ser Ser Ser Gly Ser Glu Gly Glu Ile Leu
    290                 295                 300                 
Thr Arg Glu His Ile Glu Val Glu Glu Lys Arg Ala Ser Pro Pro Val
305                 310                 315                 320 
Ser Pro Ile Pro Val Ser Glu Tyr Cys Glu Ser Glu Asn Lys Trp Ser
                325                 330                 335     
Gln Glu Lys His Ser Pro Trp Glu Gly Val Ser Asp His Leu Ala His
            340                 345                 350         
Arg Glu Pro Lys Ser Gln Lys Pro Phe Arg Lys Met Gln Glu Glu Glu
        355                 360                 365             
Glu Glu Ser Trp Ser Thr Ser Arg Asp Leu Thr Ile Ser Ile Ser Glu
    370                 375                 380                 
Asp Asp Leu Ile Leu Glu Ser Pro Glu Pro Gln Pro Asn Pro Gly Gly
385                 390                 395                 400 
Lys Met Glu Gly Glu Asp Gly Ile Glu Ala Leu Lys Leu Ile His Ala
                405                 410                 415     
Glu Gln Glu Arg Val Ala Leu Ser Thr Glu Lys Asn Cys Ile Leu Gln
            420                 425                 430         
Thr Leu Ser Ser Pro Asp Ser Glu Lys Glu Ser Ser Thr Asn Ala Pro
        435                 440                 445             
Thr Arg Glu Pro Gly Gln Thr Pro Asp Ser Asp Val Pro Arg Ala Gln
    450                 455                 460                 
Val Gly Gln His Val Ala Thr Leu Lys Glu His Asp Asn Ser Val Lys
465                 470                 475                 480 
Glu Glu Ala Thr Ala Leu Leu Arg Lys Ala Leu Thr Glu Glu Cys Gly
                485                 490                 495     
Arg Arg Ser Ala Ile His Ser Ser Glu Ser Ser Cys Ser Leu Pro Ser
            500                 505                 510         
Ile Leu Asn Asp Asn Ser Gly Ile Lys Glu Ala Lys Pro Ala Val Trp
        515                 520                 525             
Leu Asn Ser Val Pro Thr Arg Glu Gln Glu Val Ser Ser Gly Cys Gly
    530                 535                 540                 
Asp Lys Ser Lys Lys Glu Asn Val Ala Ala Asp Ile Pro Ile Thr Glu
545                 550                 555                 560 
Thr Glu Ala Tyr Gln Leu Leu Lys Lys Ala Thr Leu Gln Asp Asn Thr
                565                 570                 575     
Asn Gln Thr Glu Asn Arg Phe Gln Lys Thr Asp Ala Ser Val Ser His
            580                 585                 590         
Leu Ser Gly Leu Asn Ile Gly Ser Gly Ala Phe Glu Thr Lys Thr Ala
        595                 600                 605             
Asn Lys Ile Ala Ser Glu Ala Ser Phe Ser Ser Ser Glu Gly Ser Pro
    610                 615                 620                 
Leu Ser Arg His Glu Asn Lys Lys Lys Pro Val Ile Asn Ser Lys Ser
625                 630                 635                 640 
Asn Ala Leu Trp Asp Glu Ser Asp Asp Ser Asn Ser Glu Ile Glu Ala
                645                 650                 655     
Ala Leu Arg Pro Arg Asn His Asn Thr Asp Asp Ser Asp Asp Phe Tyr
            660                 665                 670         
Asp
    


<210> 8866
<211> 331
<212> PRT
<213> Homo sapiens

<400> 8866
Met Arg Phe Arg Phe Gly Val Val Val Pro Pro Ala Val Ala Gly Ala
 1               5                  10                  15      
Arg Pro Glu Leu Leu Val Val Gly Ser Arg Pro Glu Leu Gly Arg Trp
            20                  25                  30          
Glu Pro Arg Gly Ala Val Arg Leu Arg Pro Ala Gly Thr Ala Ala Gly
        35                  40                  45              
Asp Gly Ala Leu Ala Leu Gln Glu Pro Gly Leu Trp Leu Gly Glu Val
    50                  55                  60                  
Glu Leu Ala Ala Glu Glu Ala Ala Gln Asp Gly Ala Glu Pro Gly Arg
65                  70                  75                  80  
Val Asp Thr Phe Trp Tyr Lys Phe Leu Lys Arg Glu Pro Gly Gly Glu
                85                  90                  95      
Leu Ser Trp Glu Gly Asn Gly Pro His His Asp Arg Cys Cys Thr Tyr
            100                 105                 110         
Asn Glu Asn Asn Leu Val Asp Gly Val Tyr Cys Leu Pro Ile Gly His
        115                 120                 125             
Trp Ile Glu Ala Thr Gly His Thr Asn Glu Met Lys His Thr Thr Asp
    130                 135                 140                 
Phe Tyr Phe Asn Ile Ala Gly His Gln Ala Met His Tyr Ser Arg Ile
145                 150                 155                 160 
Leu Pro Asn Ile Trp Leu Gly Ser Cys Pro Arg Gln Val Glu His Val
                165                 170                 175     
Thr Ile Lys Leu Lys His Glu Leu Gly Ile Thr Ala Val Met Asn Phe
            180                 185                 190         
Gln Thr Glu Trp Asp Ile Val Gln Asn Ser Ser Gly Cys Asn Arg Tyr
        195                 200                 205             
Pro Glu Pro Met Thr Pro Asp Thr Met Ile Lys Leu Tyr Arg Glu Glu
    210                 215                 220                 
Gly Leu Ala Tyr Ile Trp Met Pro Thr Pro Asp Met Ser Thr Glu Gly
225                 230                 235                 240 
Arg Val Gln Met Leu Pro Gln Ala Val Cys Leu Leu His Ala Leu Leu
                245                 250                 255     
Glu Lys Gly His Ile Val Tyr Val His Cys Asn Ala Gly Val Gly Arg
            260                 265                 270         
Ser Thr Ala Ala Val Cys Gly Trp Leu Gln Tyr Val Met Gly Trp Asn
        275                 280                 285             
Leu Arg Lys Val Gln Tyr Phe Leu Met Ala Lys Arg Pro Ala Val Tyr
    290                 295                 300                 
Ile Asp Glu Glu Ala Leu Ala Arg Ala Gln Glu Asp Phe Phe Gln Lys
305                 310                 315                 320 
Phe Gly Lys Val Arg Ser Ser Val Cys Ser Leu
                325                 330     


<210> 8867
<211> 257
<212> PRT
<213> Homo sapiens

<400> 8867
Leu Val Lys Ile Gly Ser Ala Pro Glu Thr Arg Ser Lys Ile Phe Pro
 1               5                  10                  15      
Arg Phe Thr Ile Arg Arg Arg Leu Ser Arg Gly Asn Gly Pro His His
            20                  25                  30          
Asp Arg Cys Cys Thr Tyr Asn Glu Asn Asn Leu Val Asp Gly Val Tyr
        35                  40                  45              
Cys Leu Pro Ile Gly His Trp Ile Glu Ala Thr Gly His Thr Asn Glu
    50                  55                  60                  
Met Lys His Thr Thr Asp Phe Tyr Phe Asn Ile Ala Gly His Gln Ala
65                  70                  75                  80  
Met His Tyr Ser Arg Ile Leu Pro Asn Ile Trp Leu Gly Ser Cys Pro
                85                  90                  95      
Arg Gln Val Glu His Val Thr Ile Lys Leu Lys His Glu Leu Gly Ile
            100                 105                 110         
Thr Ala Val Met Asn Phe Gln Thr Glu Trp Asp Ile Val Gln Asn Ser
        115                 120                 125             
Ser Gly Cys Asn Arg Tyr Pro Glu Pro Met Thr Pro Asp Thr Met Ile
    130                 135                 140                 
Lys Leu Tyr Arg Glu Glu Gly Leu Ala Tyr Ile Trp Met Pro Thr Pro
145                 150                 155                 160 
Asp Met Ser Thr Glu Gly Arg Val Gln Met Leu Pro Gln Pro Val Cys
                165                 170                 175     
Leu Leu His Ala Leu Leu Glu Lys Gly His Ile Val Tyr Val His Cys
            180                 185                 190         
Asn Ala Gly Val Gly Arg Ser Thr Ala Ala Val Cys Gly Trp Leu Gln
        195                 200                 205             
Tyr Val Met Gly Trp Asn Leu Arg Lys Val Gln Tyr Phe Leu Met Ala
    210                 215                 220                 
Lys Arg Pro Ala Val Tyr Ile Asp Glu Glu Ala Leu Ala Arg Ala Gln
225                 230                 235                 240 
Glu Asp Phe Phe Gln Lys Phe Gly Lys Val Arg Ser Ser Val Cys Ser
                245                 250                 255     
Leu
    


<210> 8868
<211> 1237
<212> PRT
<213> Homo sapiens

<400> 8868
Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp Leu Leu Ala Ala Phe
 1               5                  10                  15      
Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile His Ser Gly Pro Glu
            20                  25                  30          
Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro Glu Pro Gly Val Gly
        35                  40                  45              
Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala Gly Asp Gly Pro Gly
    50                  55                  60                  
Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro Pro Pro Asp Ile Ser
65                  70                  75                  80  
Val Val Ser Val Ile Val Lys Asn Thr Val Cys Pro Glu Gln Ser Glu
                85                  90                  95      
Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala Gln Ala Ala Gly Val
            100                 105                 110         
Thr Lys Glu Gly Pro Val Gly Pro His Arg Met Gln Asn Gly Phe Gly
        115                 120                 125             
Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His Ser Pro Ala Pro Pro
    130                 135                 140                 
Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu Gly Lys Thr Pro Leu
145                 150                 155                 160 
Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly Asp His Ser Asp Pro
                165                 170                 175     
Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu Gly Ala Leu Thr Pro
            180                 185                 190         
Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln Glu Asn Gly Pro Gly
        195                 200                 205             
Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly Ala Leu Lys Gln Glu
    210                 215                 220                 
Ser Cys Ser Pro His His Pro Gln Val Leu Ala Gln Gln Gly Ser Gly
225                 230                 235                 240 
Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser Ala Ser Pro Pro Pro
                245                 250                 255     
Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro Gly His Gln Ser Pro
            260                 265                 270         
Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro Leu Lys Glu Glu Asp
        275                 280                 285             
Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro Gly Ser Pro Gln Ser
    290                 295                 300                 
Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp Ser Asn Asp Ser Pro
305                 310                 315                 320 
Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg Ile Lys Thr Ile Lys
                325                 330                 335     
Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr Gln Val Pro Ser Asp
            340                 345                 350         
Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala Phe Leu Ala Glu Ala
        355                 360                 365             
Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr Ser Glu Gly Pro Lys
    370                 375                 380                 
Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg Leu Lys Gly Thr Val
385                 390                 395                 400 
Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr Ala Met Leu Met Ala
                405                 410                 415     
Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro Gly Gly Thr Ala Thr
            420                 425                 430         
Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly Leu Val Pro Gln Ala
        435                 440                 445             
Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly Thr Gly Gly Gln Lys
    450                 455                 460                 
Val Asn Gly Ala Ser Val Val Met Val Gln Pro Ser Lys Thr Ala Thr
465                 470                 475                 480 
Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser Arg Thr Gln Ser Ser
                485                 490                 495     
Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser Lys Asn Leu Leu Pro
            500                 505                 510         
Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu Ala Gly Leu Ala Leu
        515                 520                 525             
Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly Asp Ala Phe Ser Leu
    530                 535                 540                 
Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg Ser Met Arg Ile Glu
545                 550                 555                 560 
Val Thr Cys Asn His Cys Ala Arg Arg Leu Val Phe Phe Asn Lys Cys
                565                 570                 575     
Ser Leu Leu Leu His Ala Arg Glu His Lys Asp Lys Gly Leu Val Met
            580                 585                 590         
Gln Cys Ser His Leu Val Met Arg Pro Val Ala Leu Asp Gln Met Val
        595                 600                 605             
Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val Ala Val Pro Pro Val
    610                 615                 620                 
Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys Gly Glu Gly Ala Ile
625                 630                 635                 640 
Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu Ala Pro Val Leu Pro
                645                 650                 655     
Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr Ser Ala Tyr Thr Cys
            660                 665                 670         
Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg Asp Lys Ala Gly Met
        675                 680                 685             
Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala Pro Gly Ala Thr Ser
    690                 695                 700                 
Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro Asn Arg Cys Ser Phe
705                 710                 715                 720 
Ser Ala His Gln Arg Met His Lys Asn Arg Pro Pro His Val Cys Pro
                725                 730                 735     
Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe Gln Thr His Leu Arg
            740                 745                 750         
Glu Ala Cys Leu His Val Ser Arg Arg Val Gly Tyr Arg Cys Pro Ser
        755                 760                 765             
Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile Lys Ser His Ile Gln
    770                 775                 780                 
Thr Ser His Cys Glu Val Phe His Lys Cys Pro Ile Cys Pro Met Ala
785                 790                 795                 800 
Phe Lys Ser Gly Pro Ser Ala His Ala His Leu Tyr Ser Gln His Pro
                805                 810                 815     
Ser Phe Gln Thr Gln Gln Ala Lys Leu Ile Tyr Lys Cys Ala Met Cys
            820                 825                 830         
Asp Thr Val Phe Thr His Lys Pro Leu Leu Ser Ser His Phe Asp Gln
        835                 840                 845             
His Leu Leu Pro Gln Arg Val Ser Val Phe Lys Cys Pro Ser Cys Pro
    850                 855                 860                 
Leu Leu Phe Ala Gln Lys Arg Thr Met Leu Glu His Leu Lys Asn Thr
865                 870                 875                 880 
His Gln Ser Gly Arg Leu Glu Glu Thr Ala Gly Lys Gly Ala Gly Gly
                885                 890                 895     
Ala Leu Leu Thr Pro Lys Thr Glu Pro Glu Glu Leu Ala Val Ser Gln
            900                 905                 910         
Gly Gly Ala Ala Pro Ala Thr Glu Glu Ser Ser Ser Ser Ser Glu Glu
        915                 920                 925             
Glu Glu Val Pro Ser Ser Pro Glu Pro Pro Arg Pro Ala Lys Arg Pro
    930                 935                 940                 
Arg Arg Glu Leu Gly Ser Lys Gly Leu Lys Gly Gly Gly Gly Gly Pro
945                 950                 955                 960 
Gly Gly Trp Thr Cys Gly Leu Cys His Ser Trp Phe Pro Glu Arg Asp
                965                 970                 975     
Glu Tyr Val Ala His Met Lys Lys Glu His Gly Lys Ser Val Lys Lys
            980                 985                 990         
Phe Pro Cys Arg Leu Cys Glu Arg Ser Phe Cys Ser Ala Pro Ser Leu
        995                 1000                1005            
Arg Arg His Val Arg Val Asn His Glu Gly Ile Lys Arg Val Tyr Pro
    1010                1015                1020                
Cys Arg Tyr Cys Thr Glu Gly Lys Arg Thr Phe Ser Ser Arg Leu Ile
1025                1030                1035                1040
Leu Glu Lys His Val Gln Val Arg His Gly Leu Gln Leu Gly Ala Gln
                1045                1050                1055    
Ser Pro Gly Arg Gly Thr Thr Leu Ala Arg Gly Ser Ser Ala Arg Ala
            1060                1065                1070        
Gln Gly Pro Gly Arg Lys Arg Arg Gln Ser Ser Asp Ser Cys Ser Glu
        1075                1080                1085            
Glu Pro Asp Ser Thr Thr Pro Pro Ala Lys Ser Pro Arg Gly Gly Pro
    1090                1095                1100                
Gly Ser Gly Gly His Gly Pro Leu Arg Tyr Arg Ser Ser Ser Ser Thr
1105                1110                1115                1120
Glu Gln Ser Leu Met Met Gly Leu Arg Val Glu Asp Gly Ala Gln Gln
                1125                1130                1135    
Cys Leu Asp Cys Gly Leu Cys Phe Ala Ser Pro Gly Ser Leu Ser Arg
            1140                1145                1150        
His Arg Phe Ile Ser His Lys Lys Arg Arg Gly Val Gly Lys Ala Ser
        1155                1160                1165            
Ala Leu Gly Leu Gly Asp Gly Glu Glu Glu Ala Pro Pro Ser Arg Ser
    1170                1175                1180                
Asp Pro Asp Gly Gly Asp Ser Pro Leu Pro Ala Ser Gly Gly Pro Leu
1185                1190                1195                1200
Thr Cys Lys Val Cys Gly Lys Ser Cys Asp Ser Pro Leu Asn Leu Lys
                1205                1210                1215    
Thr His Phe Arg Thr His Gly Met Ala Phe Ile Arg Ala Arg Gln Gly
            1220                1225                1230        
Ala Val Gly Asp Asn
        1235        


<210> 8869
<211> 1258
<212> PRT
<213> Homo sapiens

<400> 8869
Glu Leu Ser Phe Pro Leu Leu Ser Leu Asp Phe Gly Ala His Gln Gly
 1               5                  10                  15      
Leu Gly Ser Ala Asp Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp
            20                  25                  30          
Leu Leu Ala Ala Phe Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile
        35                  40                  45              
His Ser Gly Pro Glu Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro
    50                  55                  60                  
Glu Pro Gly Val Gly Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala
65                  70                  75                  80  
Gly Asp Gly Pro Gly Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro
                85                  90                  95      
Pro Pro Asp Ile Ser Val Val Ser Val Ile Val Lys Asn Thr Val Cys
            100                 105                 110         
Pro Glu Gln Ser Glu Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala
        115                 120                 125             
Gln Ala Ala Gly Val Thr Lys Glu Gly Pro Val Gly Pro His Arg Met
    130                 135                 140                 
Gln Asn Gly Phe Gly Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His
145                 150                 155                 160 
Ser Pro Ala Pro Pro Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu
                165                 170                 175     
Gly Lys Thr Pro Leu Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly
            180                 185                 190         
Asp His Ser Asp Pro Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu
        195                 200                 205             
Gly Ala Leu Thr Pro Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln
    210                 215                 220                 
Glu Asn Gly Pro Gly Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly
225                 230                 235                 240 
Ala Leu Lys Gln Glu Ser Cys Ser Pro His His Pro Gln Val Leu Ala
                245                 250                 255     
Gln Gln Gly Ser Gly Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser
            260                 265                 270         
Ala Ser Pro Pro Pro Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro
        275                 280                 285             
Gly His Gln Ser Pro Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro
    290                 295                 300                 
Leu Lys Glu Glu Asp Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro
305                 310                 315                 320 
Gly Ser Pro Gln Ser Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp
                325                 330                 335     
Ser Asn Asp Ser Pro Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg
            340                 345                 350         
Ile Lys Thr Ile Lys Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr
        355                 360                 365             
Gln Val Pro Ser Asp Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala
    370                 375                 380                 
Phe Leu Ala Glu Ala Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr
385                 390                 395                 400 
Ser Glu Gly Pro Lys Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg
                405                 410                 415     
Leu Lys Gly Thr Val Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr
            420                 425                 430         
Ala Met Leu Met Ala Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro
        435                 440                 445             
Gly Gly Thr Ala Thr Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly
    450                 455                 460                 
Leu Val Pro Gln Ala Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly
465                 470                 475                 480 
Thr Gly Gly Gln Lys Val Asn Gly Ala Ser Val Val Met Val Gln Pro
                485                 490                 495     
Ser Lys Thr Ala Thr Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser
            500                 505                 510         
Arg Thr Gln Ser Ser Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser
        515                 520                 525             
Lys Asn Leu Leu Pro Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu
    530                 535                 540                 
Ala Gly Leu Ala Leu Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly
545                 550                 555                 560 
Asp Ala Phe Ser Leu Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg
                565                 570                 575     
Ser Met Arg Ile Glu Val Thr Cys Asn His Cys Ala Arg Arg Leu Val
            580                 585                 590         
Phe Phe Asn Lys Cys Ser Leu Leu Leu His Ala Arg Glu His Lys Asp
        595                 600                 605             
Lys Gly Leu Val Met Gln Cys Ser His Leu Val Met Arg Pro Val Ala
    610                 615                 620                 
Leu Asp Gln Met Val Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val
625                 630                 635                 640 
Ala Val Pro Pro Val Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys
                645                 650                 655     
Gly Glu Gly Ala Ile Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu
            660                 665                 670         
Ala Pro Val Leu Pro Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr
        675                 680                 685             
Ser Ala Tyr Thr Cys Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg
    690                 695                 700                 
Asp Lys Ala Gly Met Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala
705                 710                 715                 720 
Pro Gly Ala Thr Ser Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro
                725                 730                 735     
Asn Arg Cys Ser Phe Ser Ala His Gln Arg Met His Lys Asn Arg Pro
            740                 745                 750         
Pro His Val Cys Pro Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe
        755                 760                 765             
Gln Thr His Leu Arg Glu Ala Cys Leu His Val Ser Arg Arg Val Gly
    770                 775                 780                 
Tyr Arg Cys Pro Ser Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile
785                 790                 795                 800 
Lys Ser His Ile Gln Thr Ser His Cys Glu Val Phe His Lys Cys Pro
                805                 810                 815     
Ile Cys Pro Met Ala Phe Lys Ser Gly Pro Ser Ala His Ala His Leu
            820                 825                 830         
Tyr Ser Gln His Pro Ser Phe Gln Thr Gln Gln Ala Lys Leu Ile Tyr
        835                 840                 845             
Lys Cys Ala Met Cys Asp Thr Val Phe Thr His Lys Pro Leu Leu Ser
    850                 855                 860                 
Ser His Phe Asp Gln His Leu Leu Pro Gln Arg Val Ser Val Phe Lys
865                 870                 875                 880 
Cys Pro Ser Cys Pro Leu Leu Phe Ala Gln Lys Arg Thr Met Leu Glu
                885                 890                 895     
His Leu Lys Asn Thr His Gln Ser Gly Arg Leu Glu Glu Thr Ala Gly
            900                 905                 910         
Lys Gly Ala Gly Gly Ala Leu Leu Thr Pro Lys Thr Glu Pro Glu Glu
        915                 920                 925             
Leu Ala Val Ser Gln Gly Gly Ala Ala Pro Ala Thr Glu Glu Ser Ser
    930                 935                 940                 
Ser Ser Ser Glu Glu Glu Glu Val Pro Ser Ser Pro Glu Pro Pro Arg
945                 950                 955                 960 
Pro Ala Lys Arg Pro Arg Arg Glu Leu Gly Ser Lys Gly Leu Lys Gly
                965                 970                 975     
Gly Gly Gly Gly Pro Gly Gly Trp Thr Cys Gly Leu Cys His Ser Trp
            980                 985                 990         
Phe Pro Glu Arg Asp Glu Tyr Val Ala His Met Lys Lys Glu His Gly
        995                 1000                1005            
Lys Ser Val Lys Lys Phe Pro Cys Arg Leu Cys Glu Arg Ser Phe Cys
    1010                1015                1020                
Ser Ala Pro Ser Leu Arg Arg His Val Arg Val Asn His Glu Gly Ile
1025                1030                1035                1040
Lys Arg Val Tyr Pro Cys Arg Tyr Cys Thr Glu Gly Lys Arg Thr Phe
                1045                1050                1055    
Ser Ser Arg Leu Ile Leu Glu Lys His Val Gln Val Arg His Gly Leu
            1060                1065                1070        
Gln Leu Gly Ala Gln Ser Pro Gly Arg Gly Thr Thr Leu Ala Arg Gly
        1075                1080                1085            
Ser Ser Ala Arg Ala Gln Gly Pro Gly Arg Lys Arg Arg Gln Ser Ser
    1090                1095                1100                
Asp Ser Cys Ser Glu Glu Pro Asp Ser Thr Thr Pro Pro Ala Lys Ser
1105                1110                1115                1120
Pro Arg Gly Gly Pro Gly Ser Gly Gly His Gly Pro Leu Arg Tyr Arg
                1125                1130                1135    
Ser Ser Ser Ser Thr Glu Gln Ser Leu Met Met Gly Leu Arg Val Glu
            1140                1145                1150        
Asp Gly Ala Gln Gln Cys Leu Asp Cys Gly Leu Cys Phe Ala Ser Pro
        1155                1160                1165            
Gly Ser Leu Ser Arg His Arg Phe Ile Ser His Lys Lys Arg Arg Gly
    1170                1175                1180                
Val Gly Lys Ala Ser Ala Leu Gly Leu Gly Asp Gly Glu Glu Glu Ala
1185                1190                1195                1200
Pro Pro Ser Arg Ser Asp Pro Asp Gly Gly Asp Ser Pro Leu Pro Ala
                1205                1210                1215    
Ser Gly Gly Pro Leu Thr Cys Lys Val Cys Gly Lys Ser Cys Asp Ser
            1220                1225                1230        
Pro Leu Asn Leu Lys Thr His Phe Arg Thr His Gly Met Ala Phe Ile
        1235                1240                1245            
Arg Ala Arg Gln Gly Ala Val Gly Asp Asn
    1250                1255            


<210> 8870
<211> 2090
<212> PRT
<213> Homo sapiens

<400> 8870
Met Pro Ala Pro Gly Ala Ser Leu Ala Leu Arg Val Ser Phe Val Asp
 1               5                  10                  15      
Val His Pro Asp Val Ile Pro Val Gln Leu Trp Gly Leu Val Gly Glu
            20                  25                  30          
Arg Arg Gly Glu Tyr Leu Arg Leu Ser Arg Glu Ile Gln Glu Ala Ala
        35                  40                  45              
Ala Thr Arg Gly Gln Trp Ala Leu Gly Ser Ala Ser Ala Ser Pro Gly
    50                  55                  60                  
Glu Leu Cys Leu Val Gln Val Gly Leu Leu Trp His Arg Cys Arg Val
65                  70                  75                  80  
Val Ser Arg Gln Ala Gln Glu Ser Arg Val Phe Leu Leu Asp Glu Gly
                85                  90                  95      
Arg Thr Ile Thr Ala Gly Ala Gly Ser Leu Ala Pro Gly Arg Arg Glu
            100                 105                 110         
Phe Phe Asn Leu Pro Ser Glu Val Leu Gly Cys Val Leu Ala Gly Leu
        115                 120                 125             
Val Pro Ala Gly Cys Gly Ala Gly Ser Gly Glu Pro Pro Gln His Trp
    130                 135                 140                 
Pro Ala Asp Ala Val Asp Phe Leu Ser Asn Leu Gln Gly Lys Glu Val
145                 150                 155                 160 
His Gly Cys Val Leu Asp Val Leu Leu Leu His Arg Leu Val Leu Leu
                165                 170                 175     
Glu Val Pro Asp Val Phe Gln Gln Met Arg Glu Leu Gly Leu Ala Arg
            180                 185                 190         
Arg Val Pro Asp Ser Leu Phe Arg Ser Leu Leu Glu Arg Tyr Leu Thr
        195                 200                 205             
Ala Ala Thr Ala Ser Val Gly Ser Gly Val Pro Val Leu Ser Arg Val
    210                 215                 220                 
Pro Leu Lys Gln Lys Gln Pro Gly Leu Asp Tyr Phe Tyr Pro Gln Leu
225                 230                 235                 240 
Gln Leu Gly Val Thr Glu Ala Val Val Ile Thr Gln Val Cys His Pro
                245                 250                 255     
His Arg Ile His Cys Gln Leu Arg Ser Val Ser Gln Glu Ile His Arg
            260                 265                 270         
Leu Ser Glu Ser Met Ala Gln Val Tyr Arg Gly Ser Thr Gly Thr Gly
        275                 280                 285             
Asp Glu Asn Ser Thr Ser Ala Thr Trp Glu Glu Arg Glu Glu Ser Pro
    290                 295                 300                 
Asp Lys Pro Gly Ser Pro Cys Ala Ser Cys Gly Leu Asp Gly His Trp
305                 310                 315                 320 
Tyr Arg Ala Leu Leu Leu Glu Thr Phe Arg Pro Gln Arg Cys Ala Gln
                325                 330                 335     
Val Leu His Val Asp Tyr Gly Arg Lys Glu Leu Val Ser Cys Ser Ser
            340                 345                 350         
Leu Arg Tyr Leu Leu Pro Glu Tyr Phe Arg Met Pro Val Val Thr Tyr
        355                 360                 365             
Pro Cys Ala Leu Tyr Gly Leu Trp Asp Gly Gly Arg Gly Trp Ser Arg
    370                 375                 380                 
Ser Gln Val Gly Asp Leu Lys Thr Leu Ile Leu Gly Lys Ala Val Asn
385                 390                 395                 400 
Ala Lys Ile Glu Phe Tyr Cys Ser Phe Glu His Val Tyr Tyr Val Ser
                405                 410                 415     
Leu Tyr Gly Glu Asp Gly Ile Asn Leu Asn Arg Val Phe Gly Val Gln
            420                 425                 430         
Ser Cys Cys Leu Ala Asp Arg Val Leu Gln Ser Gln Ala Thr Glu Glu
        435                 440                 445             
Glu Glu Pro Glu Thr Ser Gln Ser Gln Ser Pro Ala Glu Glu Val Asp
    450                 455                 460                 
Glu Glu Ile Ser Leu Pro Ala Leu Arg Ser Ile Arg Leu Lys Met Asn
465                 470                 475                 480 
Ala Phe Tyr Asp Ala Gln Val Glu Phe Val Lys Asn Pro Ser Glu Phe
                485                 490                 495     
Trp Ile Arg Leu Arg Lys His Asn Val Thr Phe Ser Lys Leu Met Arg
            500                 505                 510         
Arg Met Cys Gly Phe Tyr Ser Ser Ala Ser Lys Leu Asp Gly Val Val
        515                 520                 525             
Leu Lys Pro Glu Pro Asp Asp Leu Cys Cys Val Lys Trp Lys Glu Asn
    530                 535                 540                 
Gly Tyr Tyr Arg Ala Ile Val Thr Lys Leu Asp Asp Lys Ser Val Asp
545                 550                 555                 560 
Val Phe Leu Val Asp Arg Gly Asn Ser Glu Asn Val Asp Trp Tyr Asp
                565                 570                 575     
Val Arg Met Leu Leu Pro Gln Phe Arg Gln Leu Pro Ile Leu Ala Val
            580                 585                 590         
Lys Cys Thr Leu Ala Asp Ile Trp Pro Leu Gly Lys Thr Trp Ser Gln
        595                 600                 605             
Glu Ala Val Ser Phe Phe Lys Lys Thr Val Leu His Lys Glu Leu Val
    610                 615                 620                 
Ile His Ile Leu Asp Lys Gln Asp His Gln Tyr Val Ile Glu Ile Leu
625                 630                 635                 640 
Asp Glu Ser Arg Thr Gly Glu Glu Asn Ile Ser Lys Val Ile Ala Gln
                645                 650                 655     
Ala Gly Tyr Ala Lys Tyr Gln Glu Phe Glu Thr Lys Glu Asn Ile Leu
            660                 665                 670         
Val Asn Ala His Ser Pro Gly His Val Ser Asn His Phe Thr Thr Glu
        675                 680                 685             
Ser Asn Lys Ile Pro Phe Ala Lys Thr Gly Glu Gly Glu Gln Lys Ala
    690                 695                 700                 
Lys Arg Glu Asn Lys Thr Thr Ser Val Ser Lys Ala Leu Ser Asp Thr
705                 710                 715                 720 
Thr Val Val Thr Asn Gly Ser Thr Glu Leu Val Val Gln Glu Lys Val
                725                 730                 735     
Lys Arg Ala Ser Val Tyr Phe Pro Leu Met Gln Asn Cys Leu Glu Ile
            740                 745                 750         
Lys Pro Gly Ser Ser Ser Lys Gly Glu Leu Glu Val Gly Ser Thr Val
        755                 760                 765             
Glu Val Arg Val Ser Tyr Val Glu Asn Pro Gly Tyr Phe Trp Cys Gln
    770                 775                 780                 
Leu Thr Arg Asn Ile Gln Gly Leu Lys Thr Leu Met Ser Asp Ile Gln
785                 790                 795                 800 
Tyr Tyr Cys Lys Asn Thr Ala Ala Pro His Gln Arg Asn Thr Leu Ala
                805                 810                 815     
Cys Leu Ala Lys Arg Thr Val Asn Arg Gln Trp Ser Arg Ala Leu Ile
            820                 825                 830         
Ser Gly Ile Gln Ser Val Glu His Val Asn Val Thr Phe Val Asp Tyr
        835                 840                 845             
Gly Asp Arg Glu Met Val Ser Val Lys Asn Ile Tyr Ser Ile Ser Glu
    850                 855                 860                 
Glu Phe Leu Lys Val Lys Ala Gln Ala Phe Arg Cys Ser Leu Tyr Asn
865                 870                 875                 880 
Leu Ile Gln Pro Val Gly Gln Asn Pro Phe Val Trp Asp Val Lys Ala
                885                 890                 895     
Ile Gln Ala Phe Asn Glu Phe Ile Asp Asn Ala Trp Gln Lys Asn Leu
            900                 905                 910         
Glu Leu Lys Cys Thr Ile Phe Ala Leu Ala Ser Ile Asn Glu Glu Leu
        915                 920                 925             
Phe Asn Ile Val Asp Leu Leu Thr Pro Phe Gln Ser Ala Cys His Phe
    930                 935                 940                 
Leu Val Glu Lys Arg Leu Ala Arg Pro Val Lys Leu Gln Lys Pro Leu
945                 950                 955                 960 
Glu Ser Ser Val Gln Leu His Ser Tyr Phe Tyr Ser Thr His Asp Met
                965                 970                 975     
Lys Ile Gly Ser Glu Glu Leu Val Tyr Ile Thr His Ile Asp Asp Pro
            980                 985                 990         
Trp Thr Phe Tyr Cys Gln Leu Ala Arg Asn Ala Asn Ile Leu Glu Gln
        995                 1000                1005            
Leu Ser Cys Ser Ile Thr Gln Leu Ser Lys Val Leu Leu Asn Leu Lys
    1010                1015                1020                
Thr Ser Pro Leu Asn Pro Gly Thr Leu Cys Leu Ala Lys Tyr Thr Asp
1025                1030                1035                1040
Gly Asn Trp Tyr Arg Gly Ile Val Ile Glu Lys Glu Pro Lys Lys Val
                1045                1050                1055    
Phe Phe Val Asp Phe Gly Asn Ile Tyr Val Val Thr Ser Asp Asp Leu
            1060                1065                1070        
Leu Pro Ile Pro Ser Asp Ala Tyr Asp Val Leu Leu Leu Pro Met Gln
        1075                1080                1085            
Ala Val Arg Cys Ser Leu Ser Asp Ile Pro Asp His Ile Pro Glu Glu
    1090                1095                1100                
Val Val Val Trp Phe Gln Glu Thr Ile Leu Asp Lys Ser Leu Lys Ala
1105                1110                1115                1120
Leu Val Val Ala Lys Asp Pro Asp Gly Thr Leu Ile Ile Glu Leu Tyr
                1125                1130                1135    
Gly Asp Asn Ile Gln Ile Ser Ala Ser Ile Asn Lys Lys Leu Gly Leu
            1140                1145                1150        
Leu Ser Tyr Lys Asp Arg Ile Arg Lys Lys Glu Ser Glu Val Leu Cys
        1155                1160                1165            
Ser Thr Thr Glu Thr Leu Glu Glu Lys Asn Glu Asn Met Lys Leu Pro
    1170                1175                1180                
Cys Thr Glu Tyr Leu Ser Lys Ser Val Gly Tyr Lys Leu Pro Asn Lys
1185                1190                1195                1200
Glu Ile Leu Glu Glu Ser Tyr Lys Pro Gln Ile Asn Ser Ser Tyr Lys
                1205                1210                1215    
Glu Leu Lys Leu Leu Gln Ser Leu Thr Lys Thr Asn Leu Val Thr Gln
            1220                1225                1230        
Tyr Gln Asp Ser Val Gly Asn Lys Asn Ser Gln Val Phe Pro Leu Thr
        1235                1240                1245            
Thr Glu Lys Lys Glu Glu Ile Ser Ala Glu Thr Pro Leu Lys Thr Ala
    1250                1255                1260                
Arg Val Glu Ala Thr Leu Ser Glu Arg Lys Ile Gly Asp Ser Cys Asp
1265                1270                1275                1280
Lys Asp Leu Pro Leu Lys Phe Cys Glu Phe Pro Gln Lys Thr Ile Met
                1285                1290                1295    
Pro Gly Phe Lys Thr Thr Val Tyr Val Ser His Ile Asn Asp Leu Ser
            1300                1305                1310        
Asp Phe Tyr Val Gln Leu Ile Glu Asp Glu Ala Glu Ile Ser His Leu
        1315                1320                1325            
Ser Glu Arg Leu Asn Ser Val Lys Thr Arg Pro Glu Tyr Tyr Val Gly
    1330                1335                1340                
Pro Pro Leu Gln Arg Gly Asp Met Ile Cys Ala Val Phe Pro Glu Asp
1345                1350                1355                1360
Asn Leu Trp Tyr Arg Ala Val Ile Lys Glu Gln Gln Pro Asn Asp Leu
                1365                1370                1375    
Leu Ser Val Gln Phe Ile Asp Tyr Gly Asn Val Ser Val Val His Thr
            1380                1385                1390        
Asn Lys Ile Gly Arg Leu Asp Leu Val Asn Ala Ile Leu Pro Gly Leu
        1395                1400                1405            
Cys Ile His Cys Ser Leu Gln Gly Phe Glu Val Pro Asp Asn Lys Asn
    1410                1415                1420                
Ser Lys Lys Met Met His Tyr Phe Ser Gln Arg Thr Ser Glu Ala Ala
1425                1430                1435                1440
Ile Arg Cys Glu Phe Val Lys Phe Gln Asp Arg Trp Glu Val Ile Leu
                1445                1450                1455    
Ala Asp Glu His Gly Ile Ile Ala Asp Asp Met Ile Ser Arg Tyr Ala
            1460                1465                1470        
Leu Ser Glu Lys Ser Gln Val Glu Leu Ser Thr Gln Val Ile Lys Ser
        1475                1480                1485            
Ala Ser Ser Lys Ser Val Asn Lys Ser Asp Ile Asp Thr Ser Val Phe
    1490                1495                1500                
Leu Asn Trp Tyr Asn Pro Glu Lys Lys Met Ile Arg Ala Tyr Ala Thr
1505                1510                1515                1520
Val Ile Asp Gly Pro Glu Tyr Phe Trp Cys Gln Phe Ala Asp Thr Glu
                1525                1530                1535    
Lys Leu Gln Cys Leu Glu Val Glu Val Gln Thr Ala Gly Glu Gln Val
            1540                1545                1550        
Ala Asp Arg Arg Asn Cys Ile Pro Cys Pro Tyr Ile Gly Asp Pro Cys
        1555                1560                1565            
Ile Val Arg Tyr Arg Glu Asp Gly His Tyr Tyr Arg Ala Leu Ile Thr
    1570                1575                1580                
Asn Ile Cys Glu Asp Tyr Leu Val Ser Val Arg Leu Val Asp Phe Gly
1585                1590                1595                1600
Asn Ile Glu Asp Cys Val Asp Pro Lys Ala Leu Trp Ala Ile Pro Ser
                1605                1610                1615    
Glu Leu Leu Ser Val Pro Met Gln Ala Phe Pro Cys Cys Leu Ser Gly
            1620                1625                1630        
Phe Asn Ile Ser Glu Gly Leu Cys Ser Gln Glu Gly Asn Asp Tyr Phe
        1635                1640                1645            
Tyr Glu Ile Ile Thr Glu Asp Val Leu Glu Ile Thr Ile Leu Glu Ile
    1650                1655                1660                
Arg Arg Asp Val Cys Asp Ile Pro Leu Ala Ile Val Asp Leu Lys Ser
1665                1670                1675                1680
Lys Gly Lys Ser Ile Asn Glu Lys Met Glu Lys Tyr Ser Lys Thr Gly
                1685                1690                1695    
Ile Lys Ser Ala Leu Pro Tyr Glu Asn Ile Asp Ser Glu Ile Lys Gln
            1700                1705                1710        
Thr Leu Gly Ser Tyr Asn Leu Asp Val Gly Leu Lys Lys Leu Ser Asn
        1715                1720                1725            
Lys Ala Val Gln Asn Lys Ile Tyr Met Glu Gln Gln Thr Asp Glu Leu
    1730                1735                1740                
Ala Glu Ile Thr Glu Lys Asp Val Asn Ile Ile Gly Thr Lys Pro Ser
1745                1750                1755                1760
Asn Phe Arg Asp Pro Lys Thr Asp Asn Ile Cys Glu Gly Phe Glu Asn
                1765                1770                1775    
Pro Cys Lys Asp Lys Ile Asp Thr Glu Glu Leu Glu Gly Glu Leu Glu
            1780                1785                1790        
Cys His Leu Val Asp Lys Ala Glu Phe Asp Asp Lys Tyr Leu Ile Thr
        1795                1800                1805            
Gly Phe Asn Thr Leu Leu Pro His Ala Asn Glu Thr Lys Glu Ile Leu
    1810                1815                1820                
Glu Leu Asn Ser Leu Glu Val Pro Leu Ser Pro Asp Asp Glu Ser Lys
1825                1830                1835                1840
Glu Phe Leu Glu Leu Glu Ser Ile Glu Leu Gln Asn Ser Leu Val Val
                1845                1850                1855    
Asp Glu Glu Lys Gly Glu Leu Ser Pro Val Pro Pro Asn Val Pro Leu
            1860                1865                1870        
Ser Gln Glu Cys Val Thr Lys Gly Ala Met Glu Leu Phe Thr Leu Gln
        1875                1880                1885            
Leu Pro Leu Ser Cys Glu Ala Glu Lys Gln Pro Glu Leu Glu Leu Pro
    1890                1895                1900                
Thr Ala Gln Leu Pro Leu Asp Asp Lys Met Asp Pro Leu Ser Leu Gly
1905                1910                1915                1920
Val Ser Gln Lys Ala Gln Glu Ser Met Cys Thr Glu Asp Met Arg Lys
                1925                1930                1935    
Ser Ser Cys Val Glu Ser Phe Asp Asp Gln Arg Arg Met Ser Leu His
            1940                1945                1950        
Leu His Gly Ala Asp Cys Asp Pro Lys Thr Gln Asn Glu Met Asn Ile
        1955                1960                1965            
Cys Glu Glu Glu Phe Val Glu Tyr Lys Asn Arg Asp Ala Ile Ser Ala
    1970                1975                1980                
Leu Met Pro Leu Phe Ser Glu Glu Glu Ser Ser Asp Gly Ser Lys His
1985                1990                1995                2000
Asn Asn Gly Leu Pro Asp His Ile Ser Ala Gln Leu Gln Asn Thr Tyr
                2005                2010                2015    
Thr Leu Lys Ala Phe Thr Val Gly Ser Lys Cys Val Val Trp Ser Ser
            2020                2025                2030        
Leu Arg Asn Thr Trp Ser Lys Cys Glu Ile Leu Glu Thr Ala Glu Glu
        2035                2040                2045            
Gly Thr Arg Val Leu Asn Leu Ser Asn Gly Met Glu Glu Ile Val Asn
    2050                2055                2060                
Pro Glu Asn Val Trp Asn Gly Ile Pro Lys Leu Asp Lys Ser Pro Pro
2065                2070                2075                2080
Glu Lys Arg Gly Leu Glu Val Met Glu Ile
                2085                2090


<210> 8871
<211> 310
<212> PRT
<213> Homo sapiens

<400> 8871
Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu
 1               5                  10                  15      
Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys
            20                  25                  30          
Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro
        35                  40                  45              
Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr
    50                  55                  60                  
Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp
65                  70                  75                  80  
Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu
                85                  90                  95      
Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu
            100                 105                 110         
Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr
        115                 120                 125             
Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg
    130                 135                 140                 
Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe
145                 150                 155                 160 
Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr
                165                 170                 175     
Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg
            180                 185                 190         
Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp
        195                 200                 205             
Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp
    210                 215                 220                 
Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys
225                 230                 235                 240 
Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg
                245                 250                 255     
Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg
            260                 265                 270         
Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys
        275                 280                 285             
Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly
    290                 295                 300                 
Glu Asp Cys Pro Pro Val
305                 310 


<210> 8872
<211> 531
<212> PRT
<213> Homo sapiens

<400> 8872
Met Cys Ser Leu Ala Ser Gly Ala Thr Gly Gly Arg Gly Ala Val Glu
 1               5                  10                  15      
Asn Glu Glu Asp Leu Pro Glu Leu Ser Asp Ser Gly Asp Glu Ala Ala
            20                  25                  30          
Trp Glu Asp Glu Asp Asp Ala Asp Leu Pro His Gly Lys Gln Gln Thr
        35                  40                  45              
Pro Cys Leu Phe Cys Asn Arg Leu Phe Thr Ser Ala Glu Glu Thr Phe
    50                  55                  60                  
Ser His Cys Lys Ser Glu His Gln Phe Asn Ile Asp Ser Met Val His
65                  70                  75                  80  
Lys His Gly Leu Glu Phe Tyr Gly Tyr Ile Lys Leu Ile Asn Phe Ile
                85                  90                  95      
Arg Leu Lys Asn Pro Thr Val Glu Tyr Met Asn Ser Ile Tyr Asn Pro
            100                 105                 110         
Val Pro Trp Glu Lys Glu Glu Tyr Leu Lys Pro Val Leu Glu Asp Asp
        115                 120                 125             
Leu Leu Leu Gln Phe Asp Val Glu Asp Leu Tyr Glu Pro Val Ser Val
    130                 135                 140                 
Pro Phe Ser Tyr Pro Asn Gly Leu Ser Glu Asn Thr Ser Val Val Glu
145                 150                 155                 160 
Lys Leu Lys His Met Glu Ala Arg Ala Leu Ser Ala Glu Ala Ala Leu
                165                 170                 175     
Ala Arg Ala Arg Glu Asp Leu Gln Lys Met Lys Gln Phe Ala Gln Asp
            180                 185                 190         
Phe Val Met His Thr Asp Val Arg Thr Cys Ser Ser Ser Thr Ser Val
        195                 200                 205             
Ile Ala Asp Leu Gln Glu Asp Glu Asp Gly Val Tyr Phe Ser Ser Tyr
    210                 215                 220                 
Gly His Tyr Gly Ile His Glu Glu Met Leu Lys Asp Lys Ile Arg Thr
225                 230                 235                 240 
Glu Ser Tyr Arg Asp Phe Ile Tyr Gln Asn Pro His Ile Phe Lys Asp
                245                 250                 255     
Lys Val Val Leu Asp Val Gly Cys Gly Thr Gly Ile Leu Ser Met Phe
            260                 265                 270         
Ala Ala Lys Ala Gly Ala Lys Lys Val Leu Gly Val Asp Gln Ser Glu
        275                 280                 285             
Ile Leu Tyr Gln Ala Met Asp Ile Ile Arg Leu Asn Lys Leu Glu Asp
    290                 295                 300                 
Thr Ile Thr Leu Ile Lys Gly Lys Ile Glu Glu Val His Leu Pro Val
305                 310                 315                 320 
Glu Lys Val Asp Val Ile Ile Ser Glu Trp Met Gly Tyr Phe Leu Leu
                325                 330                 335     
Phe Glu Ser Met Leu Asp Ser Val Leu Tyr Ala Lys Asn Lys Tyr Leu
            340                 345                 350         
Ala Lys Gly Gly Ser Val Tyr Pro Asp Ile Cys Thr Ile Ser Leu Val
        355                 360                 365             
Ala Val Ser Asp Val Asn Lys His Ala Asp Arg Ile Ala Phe Trp Asp
    370                 375                 380                 
Asp Val Tyr Gly Phe Lys Met Ser Cys Met Lys Lys Ala Val Ile Pro
385                 390                 395                 400 
Glu Ala Val Val Glu Val Leu Asp Pro Lys Thr Leu Ile Ser Glu Pro
                405                 410                 415     
Cys Gly Ile Lys His Ile Asp Cys His Thr Thr Ser Ile Ser Asp Leu
            420                 425                 430         
Glu Phe Ser Ser Asp Phe Thr Leu Lys Ile Thr Arg Thr Ser Met Cys
        435                 440                 445             
Thr Ala Ile Ala Gly Tyr Phe Asp Ile Tyr Phe Glu Lys Asn Cys His
    450                 455                 460                 
Asn Arg Val Val Phe Ser Thr Gly Pro Gln Ser Thr Lys Thr His Trp
465                 470                 475                 480 
Lys Gln Thr Val Phe Leu Leu Glu Lys Pro Phe Ser Val Lys Ala Gly
                485                 490                 495     
Glu Ala Leu Lys Gly Lys Val Thr Val His Lys Ser Lys Lys Asp Pro
            500                 505                 510         
Arg Ser Leu Thr Val Thr Leu Thr Leu Asn Asn Ser Thr Gln Thr Tyr
        515                 520                 525             
Gly Leu Gln
    530     


<210> 8873
<211> 548
<212> PRT
<213> Homo sapiens

<400> 8873
Ser Asp Cys Glu Pro Ala Arg Ala Leu Arg Arg Ser Arg Arg Ser Ala
 1               5                  10                  15      
Lys Phe Pro Glu Pro Arg Ser Arg Arg Gly Phe Ala Leu Val Leu Ala
            20                  25                  30          
Leu Val Pro Gly Val Gly Gly Arg Cys Ala Arg Ser Leu Pro Asn Pro
        35                  40                  45              
Val Pro Ala Pro Arg His Ala Gly Leu Ser Gly His His Ser His Val
    50                  55                  60                  
Leu Val Ser Val Arg Arg Tyr Arg Leu Phe Thr Ser Ala Glu Glu Thr
65                  70                  75                  80  
Phe Ser His Cys Lys Ser Glu His Gln Phe Asn Ile Asp Ser Met Val
                85                  90                  95      
His Lys His Gly Leu Glu Phe Tyr Gly Tyr Ile Lys Leu Ile Asn Phe
            100                 105                 110         
Ile Arg Leu Lys Asn Pro Thr Val Glu Tyr Met Asn Ser Ile Tyr Asn
        115                 120                 125             
Pro Val Pro Trp Glu Lys Glu Glu Tyr Leu Lys Pro Val Leu Glu Asp
    130                 135                 140                 
Asp Leu Leu Leu Gln Phe Asp Val Glu Asp Leu Tyr Glu Pro Val Ser
145                 150                 155                 160 
Val Pro Phe Ser Tyr Pro Asn Gly Leu Ser Glu Asn Thr Ser Val Val
                165                 170                 175     
Glu Lys Leu Lys His Met Glu Ala Arg Ala Leu Ser Ala Glu Ala Ala
            180                 185                 190         
Leu Ala Arg Ala Arg Glu Asp Leu Gln Lys Met Lys Gln Phe Ala Gln
        195                 200                 205             
Asp Phe Val Met His Thr Asp Val Arg Thr Cys Ser Ser Ser Thr Ser
    210                 215                 220                 
Val Ile Ala Asp Leu Gln Glu Asp Glu Asp Gly Val Tyr Phe Ser Ser
225                 230                 235                 240 
Tyr Gly His Tyr Gly Ile His Glu Glu Met Leu Lys Asp Lys Ile Arg
                245                 250                 255     
Thr Glu Ser Tyr Arg Asp Phe Ile Tyr Gln Asn Pro His Ile Phe Lys
            260                 265                 270         
Asp Lys Val Val Leu Asp Val Gly Cys Gly Thr Gly Ile Leu Ser Met
        275                 280                 285             
Phe Ala Ala Lys Ala Gly Ala Lys Lys Val Leu Gly Val Asp Gln Ser
    290                 295                 300                 
Glu Ile Leu Tyr Gln Ala Met Asp Ile Ile Arg Leu Asn Lys Leu Glu
305                 310                 315                 320 
Asp Thr Ile Thr Leu Ile Lys Gly Lys Ile Glu Glu Val His Leu Pro
                325                 330                 335     
Val Glu Lys Val Asp Val Ile Ile Ser Glu Trp Met Gly Tyr Phe Leu
            340                 345                 350         
Leu Phe Glu Ser Met Leu Asp Ser Val Leu Tyr Ala Lys Asn Lys Tyr
        355                 360                 365             
Leu Ala Lys Gly Gly Ser Val Tyr Pro Asp Ile Cys Thr Ile Ser Leu
    370                 375                 380                 
Val Ala Val Ser Asp Val Asn Lys His Ala Asp Arg Ile Ala Phe Trp
385                 390                 395                 400 
Asp Asp Val Tyr Gly Phe Lys Met Ser Cys Met Lys Lys Ala Val Ile
                405                 410                 415     
Pro Glu Ala Val Val Glu Val Leu Asp Pro Lys Thr Leu Ile Ser Glu
            420                 425                 430         
Pro Cys Gly Ile Lys His Ile Asp Cys His Thr Thr Ser Ile Ser Asp
        435                 440                 445             
Leu Glu Phe Ser Ser Asp Phe Thr Leu Lys Ile Thr Arg Thr Ser Met
    450                 455                 460                 
Cys Thr Ala Ile Ala Gly Tyr Phe Asp Ile Tyr Phe Glu Lys Asn Cys
465                 470                 475                 480 
His Asn Arg Val Val Phe Ser Thr Gly Pro Gln Ser Thr Lys Thr His
                485                 490                 495     
Trp Lys Gln Thr Val Phe Leu Leu Glu Lys Pro Phe Ser Val Lys Ala
            500                 505                 510         
Gly Glu Ala Leu Lys Gly Lys Val Thr Val His Lys Asn Lys Lys Asp
        515                 520                 525             
Pro Arg Ser Leu Thr Val Thr Leu Thr Leu Asn Asn Ser Thr Gln Thr
    530                 535                 540                 
Tyr Gly Leu Gln
545             


<210> 8874
<211> 62
<212> PRT
<213> Homo sapiens

<400> 8874
Met Asp Pro Asn Cys Ser Cys Ala Ala Ala Gly Val Ser Cys Thr Cys
 1               5                  10                  15      
Ala Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys
            20                  25                  30          
Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly
        35                  40                  45              
Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala
    50                  55                  60          


<210> 8875
<211> 1030
<212> PRT
<213> Homo sapiens

<400> 8875
Met Glu Pro Leu Arg His Ser Pro Gly Pro Gly Gly Gln Arg Leu Leu
 1               5                  10                  15      
Leu Pro Ser Met Leu Leu Ala Leu Leu Leu Leu Leu Ala Pro Ser Pro
            20                  25                  30          
Gly His Ala Thr Arg Val Val Tyr Lys Val Pro Glu Glu Gln Pro Pro
        35                  40                  45              
Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp Tyr Gly Phe Pro Asp Val
    50                  55                  60                  
Gly His Leu Tyr Lys Leu Glu Val Gly Ala Pro Tyr Leu Arg Val Asp
65                  70                  75                  80  
Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu Thr Ser Ile Asp Arg Glu
                85                  90                  95      
Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro Gly Asp Pro Cys Ile Leu
            100                 105                 110         
Glu Phe Glu Val Ser Ile Thr Asp Leu Val Gln Asn Ala Ser Pro Arg
        115                 120                 125             
Leu Leu Glu Gly Gln Ile Glu Val Gln Asp Ile Asn Asp Asn Thr Pro
    130                 135                 140                 
Asn Phe Ala Ser Pro Val Ile Thr Leu Ala Ile Pro Glu Asn Thr Asn
145                 150                 155                 160 
Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala Ser Asp Arg Asp Ala Gly
                165                 170                 175     
Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln Val Ala Glu Asp Gln Glu
            180                 185                 190         
Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg Glu Arg
        195                 200                 205             
Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly Ser Pro
    210                 215                 220                 
Pro Arg Ala Thr Ser Ala Leu Leu Arg Val Thr Val Leu Asp Thr Asn
225                 230                 235                 240 
Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu Leu Ser
                245                 250                 255     
Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala Asn Asp
            260                 265                 270         
Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His Gln Ala
        275                 280                 285             
Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr Gly Leu
    290                 295                 300                 
Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr Leu Arg
305                 310                 315                 320 
Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser Ala Arg
                325                 330                 335     
Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala Pro Thr
            340                 345                 350         
Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly Met Ala
        355                 360                 365             
Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu Val Gln
    370                 375                 380                 
Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys Val Val
385                 390                 395                 400 
Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr Gly Ser
                405                 410                 415     
Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu Asp Tyr
            420                 425                 430         
Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp Ser Gly
        435                 440                 445             
Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val Val Asp
    450                 455                 460                 
Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu Val Ala
465                 470                 475                 480 
Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile Thr Ala
                485                 490                 495     
Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser Leu Glu
            500                 505                 510         
Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu Thr Gly
        515                 520                 525             
Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu Ser Tyr
    530                 535                 540                 
Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu Gln Gly
545                 550                 555                 560 
Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn Asp Pro
                565                 570                 575     
Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn Met Pro
            580                 585                 590         
Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp Lys Gly
        595                 600                 605             
Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly Asp Phe
    610                 615                 620                 
Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser Phe Asp
625                 630                 635                 640 
Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val Asp Gly
                645                 650                 655     
Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn Val Leu
            660                 665                 670         
Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn Thr Ser
        675                 680                 685             
His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val Ser Gln
    690                 695                 700                 
Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu Ile Tyr
705                 710                 715                 720 
Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly Ser His
                725                 730                 735     
Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His His Gly
            740                 745                 750         
Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro Pro Arg
        755                 760                 765             
Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu Ala Asn
    770                 775                 780                 
Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr Pro Leu
785                 790                 795                 800 
Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys Gln Arg
                805                 810                 815     
Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val Ala Leu
            820                 825                 830         
Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg Glu Ala
        835                 840                 845             
Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu Tyr Ala
    850                 855                 860                 
Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys Gly Lys
865                 870                 875                 880 
Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu Asp Glu
                885                 890                 895     
Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp Ala Pro
            900                 905                 910         
Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro Gly Ser
        915                 920                 925             
Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro Ser Ile
    930                 935                 940                 
Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln Val Val
945                 950                 955                 960 
Gln Asp Leu Pro Pro Ala Asn Thr Phe Val Gly Thr Gly Asp Thr Thr
                965                 970                 975     
Ser Thr Gly Ser Glu Gln Tyr Ser Asp Tyr Ser Tyr Arg Thr Asn Pro
            980                 985                 990         
Pro Lys Tyr Pro Ser Lys Gln Leu Pro His Arg Arg Val Thr Phe Ser
        995                 1000                1005            
Ala Thr Ser Gln Ala Gln Glu Leu Gln Asp Pro Ser Gln His Ser Tyr
    1010                1015                1020                
Tyr Asp Ser Gly Leu Glu
1025                1030


<210> 8876
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 8876
Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu
 1               5                  10                  15      
Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro
            20                  25                  30          
Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu
        35                  40                  45              
Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val
    50                  55                  60                  
Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp
65                  70                  75                  80  
Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala
                85                  90                  95      
Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu
            100                 105                 110         
Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro
        115                 120                 125             
Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val
    130                 135                 140                 
Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp
145                 150                 155                 160 
Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala
                165                 170                 175     
Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala
            180                 185                 190         
Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln
        195                 200                 205             
Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp
    210                 215                 220                 
Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg
225                 230                 235                 240 
Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly
                245                 250                 255     
Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp
            260                 265                 270         
Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu
        275                 280                 285             
Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala
    290                 295                 300                 
Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His
305                 310                 315                 320 
Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr
                325                 330                 335     
Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr
            340                 345                 350         
Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser
        355                 360                 365             
Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala
    370                 375                 380                 
Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly
385                 390                 395                 400 
Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu
                405                 410                 415     
Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys
            420                 425                 430         
Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr
        435                 440                 445             
Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu
    450                 455                 460                 
Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp
465                 470                 475                 480 
Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val
                485                 490                 495     
Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu
            500                 505                 510         
Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile
        515                 520                 525             
Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser
    530                 535                 540                 
Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu
545                 550                 555                 560 
Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu
                565                 570                 575     
Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu
            580                 585                 590         
Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn
        595                 600                 605             
Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn
    610                 615                 620                 
Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp
625                 630                 635                 640 
Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly
                645                 650                 655     
Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser
            660                 665                 670         
Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val
        675                 680                 685             
Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn
    690                 695                 700                 
Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn
705                 710                 715                 720 
Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val
                725                 730                 735     
Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu
            740                 745                 750         
Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly
        755                 760                 765             
Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His
    770                 775                 780                 
His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro
785                 790                 795                 800 
Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu
                805                 810                 815     
Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr
            820                 825                 830         
Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys
        835                 840                 845             
Gln Arg Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val
    850                 855                 860                 
Ala Leu Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg
865                 870                 875                 880 
Glu Ala Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu
                885                 890                 895     
Tyr Ala Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys
            900                 905                 910         
Gly Lys Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu
        915                 920                 925             
Asp Glu Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp
    930                 935                 940                 
Ala Pro Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro
945                 950                 955                 960 
Gly Ser Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro
                965                 970                 975     
Ser Ile Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln
            980                 985                 990         
Val Val Gln Asp Leu Pro Pro Ala Asn Thr Phe Val Gly Thr Gly Asp
        995                 1000                1005            
Thr Thr Ser Thr Gly Ser Glu Gln Tyr Ser Asp Tyr Ser Tyr Arg Thr
    1010                1015                1020                
Asn Pro Pro Lys Tyr Pro Ser Lys Gln Val Gly Gln Pro Phe Gln Leu
1025                1030                1035                1040
Ser Thr Pro Gln Pro Leu Pro His Pro Tyr His Gly Ala Ile Trp Thr
                1045                1050                1055    
Glu Val Trp Glu
            1060


<210> 8877
<211> 1237
<212> PRT
<213> Homo sapiens

<400> 8877
Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu
 1               5                  10                  15      
Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro
            20                  25                  30          
Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu
        35                  40                  45              
Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val
    50                  55                  60                  
Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp
65                  70                  75                  80  
Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala
                85                  90                  95      
Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu
            100                 105                 110         
Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro
        115                 120                 125             
Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val
    130                 135                 140                 
Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp
145                 150                 155                 160 
Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala
                165                 170                 175     
Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala
            180                 185                 190         
Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln
        195                 200                 205             
Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp
    210                 215                 220                 
Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg
225                 230                 235                 240 
Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly
                245                 250                 255     
Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp
            260                 265                 270         
Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu
        275                 280                 285             
Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala
    290                 295                 300                 
Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His
305                 310                 315                 320 
Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr
                325                 330                 335     
Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr
            340                 345                 350         
Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser
        355                 360                 365             
Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala
    370                 375                 380                 
Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly
385                 390                 395                 400 
Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu
                405                 410                 415     
Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys
            420                 425                 430         
Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr
        435                 440                 445             
Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu
    450                 455                 460                 
Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp
465                 470                 475                 480 
Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val
                485                 490                 495     
Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu
            500                 505                 510         
Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile
        515                 520                 525             
Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser
    530                 535                 540                 
Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu
545                 550                 555                 560 
Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu
                565                 570                 575     
Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu
            580                 585                 590         
Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn
        595                 600                 605             
Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn
    610                 615                 620                 
Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp
625                 630                 635                 640 
Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly
                645                 650                 655     
Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser
            660                 665                 670         
Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val
        675                 680                 685             
Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn
    690                 695                 700                 
Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn
705                 710                 715                 720 
Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val
                725                 730                 735     
Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu
            740                 745                 750         
Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly
        755                 760                 765             
Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His
    770                 775                 780                 
His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro
785                 790                 795                 800 
Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu
                805                 810                 815     
Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr
            820                 825                 830         
Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys
        835                 840                 845             
Gln Arg Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val
    850                 855                 860                 
Ala Leu Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg
865                 870                 875                 880 
Glu Ala Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu
                885                 890                 895     
Tyr Ala Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys
            900                 905                 910         
Gly Lys Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu
        915                 920                 925             
Asp Glu Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp
    930                 935                 940                 
Ala Pro Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro
945                 950                 955                 960 
Gly Ser Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro
                965                 970                 975     
Ser Ile Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln
            980                 985                 990         
Val Val Gln Asp Leu Pro Pro Ala Asn Thr Phe Val Gly Thr Gly Asp
        995                 1000                1005            
Thr Thr Ser Thr Gly Ser Glu Gln Tyr Ser Asp Tyr Ser Tyr Arg Thr
    1010                1015                1020                
Asn Pro Pro Lys Tyr Pro Ser Lys Gln Leu Pro His Arg Arg Val Thr
1025                1030                1035                1040
Phe Ser Ala Thr Ser Gln Ala Gln Glu Leu Gln Asp Pro Ser Gln His
                1045                1050                1055    
Ser Tyr Tyr Asp Ser Gly Leu Glu Glu Ser Glu Thr Pro Ser Ser Lys
            1060                1065                1070        
Ser Ser Ser Gly Pro Arg Leu Gly Pro Leu Ala Leu Pro Glu Asp His
        1075                1080                1085            
Tyr Glu Arg Thr Thr Pro Asp Gly Ser Ile Gly Glu Met Glu His Pro
    1090                1095                1100                
Glu Asn Asp Leu Arg Pro Leu Pro Asp Val Ala Met Thr Gly Thr Cys
1105                1110                1115                1120
Thr Arg Glu Cys Ser Glu Phe Gly His Ser Asp Thr Cys Trp Met Pro
                1125                1130                1135    
Gly Gln Ser Ser Pro Ser Arg Arg Thr Lys Ser Ser Ala Leu Lys Leu
            1140                1145                1150        
Ser Thr Phe Val Pro Tyr Gln Asp Arg Gly Gly Gln Glu Pro Ala Gly
        1155                1160                1165            
Ala Gly Ser Pro Ser Pro Pro Glu Asp Arg Asn Thr Lys Thr Ala Pro
    1170                1175                1180                
Val Arg Leu Leu Pro Ser Tyr Ser Ala Phe Ser His Ser Ser His Asp
1185                1190                1195                1200
Ser Cys Lys Asp Ser Ala Thr Leu Glu Glu Ile Pro Leu Thr Gln Thr
                1205                1210                1215    
Ser Asp Phe Pro Pro Ala Ala Thr Pro Ala Ser Ala Gln Thr Ala Lys
            1220                1225                1230        
Arg Glu Ile Tyr Leu
        1235        


<210> 8878
<211> 1026
<212> PRT
<213> Homo sapiens

<400> 8878
Met Glu Pro Leu Arg His Ser Pro Gly Pro Gly Gly Gln Arg Leu Leu
 1               5                  10                  15      
Leu Pro Ser Met Leu Leu Ala Leu Leu Leu Leu Leu Ala Pro Ser Pro
            20                  25                  30          
Gly His Ala Thr Arg Val Val Tyr Lys Val Pro Glu Glu Gln Pro Pro
        35                  40                  45              
Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp Tyr Gly Phe Pro Asp Val
    50                  55                  60                  
Gly His Leu Tyr Lys Leu Glu Val Gly Ala Pro Tyr Leu Arg Val Asp
65                  70                  75                  80  
Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu Thr Ser Ile Asp Arg Glu
                85                  90                  95      
Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro Gly Asp Pro Cys Ile Leu
            100                 105                 110         
Glu Phe Glu Val Ser Ile Thr Asp Leu Val Gln Asn Ala Ser Pro Arg
        115                 120                 125             
Leu Leu Glu Gly Gln Ile Glu Val Gln Asp Ile Asn Asp Asn Thr Pro
    130                 135                 140                 
Asn Phe Ala Ser Pro Val Ile Thr Leu Ala Ile Pro Glu Asn Thr Asn
145                 150                 155                 160 
Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala Ser Asp Arg Asp Ala Gly
                165                 170                 175     
Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln Val Ala Glu Asp Gln Glu
            180                 185                 190         
Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg Glu Arg
        195                 200                 205             
Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly Ser Pro
    210                 215                 220                 
Pro Arg Ala Thr Ser Ala Leu Leu Arg Val Thr Val Leu Asp Thr Asn
225                 230                 235                 240 
Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu Leu Ser
                245                 250                 255     
Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala Asn Asp
            260                 265                 270         
Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His Gln Ala
        275                 280                 285             
Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr Gly Leu
    290                 295                 300                 
Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr Leu Arg
305                 310                 315                 320 
Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser Ala Arg
                325                 330                 335     
Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala Pro Thr
            340                 345                 350         
Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly Met Ala
        355                 360                 365             
Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu Val Gln
    370                 375                 380                 
Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys Val Val
385                 390                 395                 400 
Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr Gly Ser
                405                 410                 415     
Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu Asp Tyr
            420                 425                 430         
Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp Ser Gly
        435                 440                 445             
Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val Val Asp
    450                 455                 460                 
Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu Val Ala
465                 470                 475                 480 
Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile Thr Ala
                485                 490                 495     
Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser Leu Glu
            500                 505                 510         
Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu Thr Gly
        515                 520                 525             
Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu Ser Tyr
    530                 535                 540                 
Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu Gln Gly
545                 550                 555                 560 
Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn Asp Pro
                565                 570                 575     
Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn Met Pro
            580                 585                 590         
Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp Lys Gly
        595                 600                 605             
Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly Asp Phe
    610                 615                 620                 
Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser Phe Asp
625                 630                 635                 640 
Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val Asp Gly
                645                 650                 655     
Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn Val Leu
            660                 665                 670         
Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn Thr Ser
        675                 680                 685             
His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val Ser Gln
    690                 695                 700                 
Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu Ile Tyr
705                 710                 715                 720 
Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly Ser His
                725                 730                 735     
Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His His Gly
            740                 745                 750         
Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro Pro Arg
        755                 760                 765             
Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu Ala Asn
    770                 775                 780                 
Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr Pro Leu
785                 790                 795                 800 
Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys Gln Arg
                805                 810                 815     
Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val Ala Leu
            820                 825                 830         
Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg Glu Ala
        835                 840                 845             
Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu Tyr Ala
    850                 855                 860                 
Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys Gly Lys
865                 870                 875                 880 
Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu Asp Glu
                885                 890                 895     
Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp Ala Pro
            900                 905                 910         
Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro Gly Ser
        915                 920                 925             
Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro Ser Ile
    930                 935                 940                 
Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln Val Val
945                 950                 955                 960 
Gln Asp Leu Pro Pro Ala Asn Thr Phe Val Gly Thr Gly Asp Thr Thr
                965                 970                 975     
Ser Thr Gly Ser Glu Gln Tyr Ser Asp Tyr Ser Tyr Arg Thr Asn Pro
            980                 985                 990         
Pro Lys Tyr Pro Ser Lys Gln Val Gly Gln Pro Phe Gln Leu Ser Thr
        995                 1000                1005            
Pro Gln Pro Leu Pro His Pro Tyr His Gly Ala Ile Trp Thr Glu Val
    1010                1015                1020                
Trp Glu
1025    


<210> 8879
<211> 209
<212> PRT
<213> Homo sapiens

<400> 8879
Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu
 1               5                  10                  15      
Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe
            20                  25                  30          
Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly
        35                  40                  45              
Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln
    50                  55                  60                  
Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly
65                  70                  75                  80  
Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu
                85                  90                  95      
Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp
            100                 105                 110         
Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile
        115                 120                 125             
Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys
    130                 135                 140                 
Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro
145                 150                 155                 160 
Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln
                165                 170                 175     
Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala
            180                 185                 190         
Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Ser
        195                 200                 205             
Gly
    


<210> 8880
<211> 435
<212> PRT
<213> Homo sapiens

<400> 8880
Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu
 1               5                  10                  15      
Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe
            20                  25                  30          
Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly
        35                  40                  45              
Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln
    50                  55                  60                  
Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly
65                  70                  75                  80  
Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu
                85                  90                  95      
Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp
            100                 105                 110         
Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile
        115                 120                 125             
Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys
    130                 135                 140                 
Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro
145                 150                 155                 160 
Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln
                165                 170                 175     
Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala
            180                 185                 190         
Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr
        195                 200                 205             
Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly
    210                 215                 220                 
Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg
225                 230                 235                 240 
Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly
                245                 250                 255     
Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val
            260                 265                 270         
Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln
        275                 280                 285             
Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu
    290                 295                 300                 
His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu
305                 310                 315                 320 
Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile
                325                 330                 335     
Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr
            340                 345                 350         
Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg
        355                 360                 365             
Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro
    370                 375                 380                 
Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu
385                 390                 395                 400 
Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe
                405                 410                 415     
Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys
            420                 425                 430         
Ser Met Trp
        435 


<210> 8881
<211> 405
<212> PRT
<213> Homo sapiens

<400> 8881
Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu
 1               5                  10                  15      
Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe
            20                  25                  30          
Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly
        35                  40                  45              
Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln
    50                  55                  60                  
Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly
65                  70                  75                  80  
Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu
                85                  90                  95      
Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp
            100                 105                 110         
Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile
        115                 120                 125             
Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys
    130                 135                 140                 
Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro
145                 150                 155                 160 
Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln
                165                 170                 175     
Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala
            180                 185                 190         
Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr
        195                 200                 205             
Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly
    210                 215                 220                 
Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg
225                 230                 235                 240 
Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly
                245                 250                 255     
Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val
            260                 265                 270         
Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln
        275                 280                 285             
Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Glu Ser Cys Gln
    290                 295                 300                 
Ala Ile Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn
305                 310                 315                 320 
Val Thr Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His
                325                 330                 335     
Gly Arg Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu
            340                 345                 350         
Asn Pro Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu
        355                 360                 365             
Ser Leu Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val
    370                 375                 380                 
Glu Phe Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu
385                 390                 395                 400 
Arg Lys Ser Met Trp
                405 


<210> 8882
<211> 130
<212> PRT
<213> Homo sapiens

<400> 8882
Met Thr Cys Ser Pro Leu Leu Leu Thr Leu Leu Ile His Cys Thr Gly
 1               5                  10                  15      
Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala
            20                  25                  30          
Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile
        35                  40                  45              
Gly Asn Asp Tyr Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp
65                  70                  75                  80  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr
                85                  90                  95      
Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asn
            100                 105                 110         
Asn Ser Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
        115                 120                 125             
Leu Gly
    130 


<210> 8883
<211> 485
<212> PRT
<213> Homo sapiens

<400> 8883
Met Arg Ser Arg Val Ala Val Arg Ala Cys His Lys Val Cys Arg Cys
 1               5                  10                  15      
Leu Leu Ser Gly Phe Gly Gly Arg Val Asp Ala Gly Gln Pro Glu Leu
            20                  25                  30          
Leu Thr Glu Arg Ser Ser Pro Lys Gly Gly His Val Lys Ser His Ala
        35                  40                  45              
Glu Leu Glu Gly Asn Gly Glu His Pro Glu Ala Pro Gly Ser Gly Glu
    50                  55                  60                  
Gly Ser Glu Ala Leu Leu Glu Ile Cys Gln Arg Arg His Phe Leu Ser
65                  70                  75                  80  
Gly Ser Lys Gln Gln Leu Ser Arg Asp Ser Leu Leu Ser Gly Cys His
                85                  90                  95      
Pro Gly Phe Gly Pro Leu Gly Val Glu Leu Arg Lys Asn Leu Ala Ala
            100                 105                 110         
Glu Trp Trp Thr Ser Val Val Val Phe Arg Glu Gln Val Phe Pro Val
        115                 120                 125             
Asp Ala Leu His His Lys Pro Gly Pro Leu Leu Pro Gly Asp Ser Ala
    130                 135                 140                 
Phe Arg Leu Val Ser Ala Glu Thr Leu Arg Glu Ile Leu Gln Asp Lys
145                 150                 155                 160 
Glu Leu Ser Lys Glu Gln Leu Val Ala Phe Leu Glu Asn Val Leu Lys
                165                 170                 175     
Thr Ser Gly Lys Leu Arg Glu Asn Leu Leu His Gly Ala Leu Glu His
            180                 185                 190         
Tyr Val Asn Cys Leu Asp Leu Val Asn Lys Arg Leu Pro Tyr Gly Leu
        195                 200                 205             
Ala Gln Ile Gly Val Cys Phe His Pro Val Phe Asp Thr Lys Gln Ile
    210                 215                 220                 
Arg Asn Gly Val Lys Ser Ile Gly Glu Lys Thr Glu Ala Ser Leu Val
225                 230                 235                 240 
Trp Phe Thr Pro Pro Arg Thr Ser Asn Gln Trp Leu Asp Phe Trp Leu
                245                 250                 255     
Arg His Arg Leu Gln Trp Trp Arg Lys Phe Ala Met Ser Pro Ser Asn
            260                 265                 270         
Phe Ser Ser Ser Asp Cys Gln Asp Glu Glu Gly Arg Lys Gly Asn Lys
        275                 280                 285             
Leu Tyr Tyr Asn Phe Pro Trp Gly Lys Glu Leu Ile Glu Thr Leu Trp
    290                 295                 300                 
Asn Leu Gly Asp His Glu Leu Leu His Met Tyr Pro Gly Asn Val Ser
305                 310                 315                 320 
Lys Leu His Gly Arg Asp Gly Arg Lys Asn Val Val Pro Cys Val Leu
                325                 330                 335     
Ser Val Asn Gly Asp Leu Asp Arg Gly Met Leu Ala Tyr Leu Tyr Asp
            340                 345                 350         
Ser Phe Gln Leu Thr Glu Asn Ser Phe Thr Arg Lys Lys Asn Leu His
        355                 360                 365             
Arg Lys Val Leu Lys Leu His Pro Cys Leu Ala Pro Ile Lys Val Ala
    370                 375                 380                 
Leu Asp Val Gly Arg Gly Pro Thr Leu Glu Leu Arg Gln Val Cys Gln
385                 390                 395                 400 
Gly Leu Phe Asn Glu Leu Leu Glu Asn Gly Ile Ser Val Trp Pro Gly
                405                 410                 415     
Tyr Leu Glu Thr Met Gln Ser Ser Leu Glu Gln Leu Tyr Ser Lys Tyr
            420                 425                 430         
Asp Glu Met Ser Ile Leu Phe Thr Val Leu Val Thr Glu Thr Thr Leu
        435                 440                 445             
Glu Asn Gly Leu Ile His Leu Arg Ser Arg Asp Thr Thr Met Lys Glu
    450                 455                 460                 
Met Met His Ile Ser Lys Leu Lys Asp Phe Leu Ile Lys Tyr Ile Ser
465                 470                 475                 480 
Ser Ala Lys Asn Val
                485 


<210> 8884
<211> 409
<212> PRT
<213> Homo sapiens

<400> 8884
Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val
 1               5                  10                  15      
Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr
            20                  25                  30          
Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val
        35                  40                  45              
Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala
    50                  55                  60                  
Leu Ile Asn Cys Ser Val Tyr Gly Ile Pro Asp Pro Gln Phe Lys Trp
65                  70                  75                  80  
Tyr Asn Ser Ile Gly Lys Leu Leu Lys Glu Glu Glu Asp Glu Lys Glu
                85                  90                  95      
Arg Gly Gly Gly Lys Trp Gln Met His Asp Ser Gly Leu Leu Asn Ile
            100                 105                 110         
Thr Lys Val Ser Phe Ser Asp Arg Gly Lys Tyr Thr Cys Val Ala Ser
        115                 120                 125             
Asn Ile Tyr Gly Thr Val Asn Asn Thr Val Thr Leu Arg Val Ile Phe
    130                 135                 140                 
Thr Ser Gly Asp Met Gly Val Tyr Tyr Met Val Val Cys Leu Val Ala
145                 150                 155                 160 
Phe Thr Ile Val Met Val Leu Asn Ile Thr Arg Leu Cys Met Met Ser
                165                 170                 175     
Ser His Leu Lys Lys Thr Glu Lys Ala Ile Asn Glu Phe Phe Arg Thr
            180                 185                 190         
Glu Gly Ala Glu Lys Leu Gln Lys Ala Phe Glu Ile Ala Lys Arg Ile
        195                 200                 205             
Pro Ile Ile Thr Ser Ala Lys Thr Leu Glu Leu Ala Lys Val Thr Gln
    210                 215                 220                 
Phe Lys Thr Met Glu Phe Ala Arg Tyr Ile Glu Glu Leu Ala Arg Ser
225                 230                 235                 240 
Val Pro Leu Pro Pro Leu Ile Met Asn Cys Arg Thr Ile Met Glu Glu
                245                 250                 255     
Ile Met Glu Val Val Gly Leu Glu Glu Gln Gly Gln Asn Phe Val Arg
            260                 265                 270         
His Thr Pro Glu Gly Gln Glu Ala Ala Asp Arg Asp Glu Val Tyr Thr
        275                 280                 285             
Ile Pro Asn Ser Leu Lys Arg Ser Asp Ser Pro Ala Ala Asp Ser Asp
    290                 295                 300                 
Ala Ser Ser Leu His Glu Gln Pro Gln Gln Ile Ala Ile Lys Val Ser
305                 310                 315                 320 
Val His Pro Gln Ser Lys Lys Glu His Ala Asp Asp Gln Glu Gly Gly
                325                 330                 335     
Gln Phe Glu Val Lys Asp Val Glu Glu Thr Glu Leu Ser Ala Glu His
            340                 345                 350         
Ser Pro Glu Thr Ala Glu Pro Ser Thr Asp Val Thr Ser Thr Glu Leu
        355                 360                 365             
Thr Ser Glu Glu Pro Thr Pro Val Glu Val Pro Asp Lys Val Leu Pro
    370                 375                 380                 
Pro Ala Tyr Leu Glu Ala Thr Glu Pro Ala Val Thr His Asp Lys Asn
385                 390                 395                 400 
Thr Cys Ile Ile Tyr Glu Ser His Val
                405                 


<210> 8885
<211> 708
<212> PRT
<213> Homo sapiens

<400> 8885
Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile
 1               5                  10                  15      
Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu
            20                  25                  30          
Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met
        35                  40                  45              
Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro
    50                  55                  60                  
Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn
65                  70                  75                  80  
Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly
                85                  90                  95      
Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val
            100                 105                 110         
Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu
        115                 120                 125             
Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu
    130                 135                 140                 
Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe
145                 150                 155                 160 
Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu
                165                 170                 175     
Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile
            180                 185                 190         
Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe
        195                 200                 205             
Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu
    210                 215                 220                 
Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser
225                 230                 235                 240 
Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu
                245                 250                 255     
Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile
            260                 265                 270         
Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu
        275                 280                 285             
Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala
    290                 295                 300                 
Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro
305                 310                 315                 320 
Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu
                325                 330                 335     
Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly
            340                 345                 350         
Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn
        355                 360                 365             
Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr
    370                 375                 380                 
Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro
385                 390                 395                 400 
Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met
                405                 410                 415     
Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu
            420                 425                 430         
Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala
        435                 440                 445             
Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu
    450                 455                 460                 
Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr
465                 470                 475                 480 
Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys
                485                 490                 495     
Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys
            500                 505                 510         
Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys
        515                 520                 525             
Ile Arg Asp Ile Gln Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser
    530                 535                 540                 
Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr
545                 550                 555                 560 
Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys
                565                 570                 575     
Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys
            580                 585                 590         
Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn
        595                 600                 605             
Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn
    610                 615                 620                 
Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile
625                 630                 635                 640 
Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp
                645                 650                 655     
Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala
            660                 665                 670         
Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys
        675                 680                 685             
Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro
    690                 695                 700                 
Thr Asn Met Ser
705             


<210> 8886
<211> 135
<212> PRT
<213> Homo sapiens

<400> 8886
Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu
 1               5                  10                  15      
Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys
            20                  25                  30          
Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr
        35                  40                  45              
Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe
    50                  55                  60                  
Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile
65                  70                  75                  80  
His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser
                85                  90                  95      
Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu
            100                 105                 110         
Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val
        115                 120                 125             
Gln Met Phe Ile Asn Thr Ser
    130                 135 


<210> 8887
<211> 136
<212> PRT
<213> Homo sapiens

<400> 8887
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser
 1               5                  10                  15      
Val Ile Met Ser Arg Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys
            20                  25                  30          
Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr
        35                  40                  45              
Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys
    50                  55                  60                  
Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser
65                  70                  75                  80  
Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu
                85                  90                  95      
Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu
            100                 105                 110         
Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile
        115                 120                 125             
Val Gln Met Phe Ile Asn Thr Ser
    130                 135     


<210> 8888
<211> 162
<212> PRT
<213> Homo sapiens

<400> 8888
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr
 1               5                  10                  15      
Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His
            20                  25                  30          
Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala
        35                  40                  45              
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile
    50                  55                  60                  
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His
65                  70                  75                  80  
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln
                85                  90                  95      
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu
            100                 105                 110         
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val
        115                 120                 125             
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile
    130                 135                 140                 
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn
145                 150                 155                 160 
Thr Ser
        


<210> 8889
<211> 1181
<212> PRT
<213> Homo sapiens

<400> 8889
Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val
 1               5                  10                  15      
Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val
            20                  25                  30          
Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe
        35                  40                  45              
Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu
    50                  55                  60                  
Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val
65                  70                  75                  80  
Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn
                85                  90                  95      
Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn
            100                 105                 110         
Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe
        115                 120                 125             
Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr
    130                 135                 140                 
Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala
145                 150                 155                 160 
Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val
                165                 170                 175     
Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys
            180                 185                 190         
Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys
        195                 200                 205             
Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe
    210                 215                 220                 
Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser
225                 230                 235                 240 
Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile
                245                 250                 255     
Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg
            260                 265                 270         
Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp
        275                 280                 285             
Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile
    290                 295                 300                 
Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu
305                 310                 315                 320 
Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro
                325                 330                 335     
Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu
            340                 345                 350         
Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val
        355                 360                 365             
Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser
    370                 375                 380                 
Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly
385                 390                 395                 400 
Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His
                405                 410                 415     
Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn
            420                 425                 430         
His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu
        435                 440                 445             
Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln
    450                 455                 460                 
Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln
465                 470                 475                 480 
Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys
                485                 490                 495     
Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly
            500                 505                 510         
Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr
        515                 520                 525             
Leu Phe Thr Ile Lys Lys Gly Ile Leu Gly Gln His Gln Phe Leu Glu
    530                 535                 540                 
Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala
545                 550                 555                 560 
Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser
                565                 570                 575     
Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His
            580                 585                 590         
Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp
        595                 600                 605             
Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly
    610                 615                 620                 
Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala
625                 630                 635                 640 
Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala
                645                 650                 655     
Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn
            660                 665                 670         
Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr
        675                 680                 685             
Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala
    690                 695                 700                 
Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn
705                 710                 715                 720 
Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser
                725                 730                 735     
Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn
            740                 745                 750         
Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser
        755                 760                 765             
Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro
    770                 775                 780                 
Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val
785                 790                 795                 800 
Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val
                805                 810                 815     
Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys
            820                 825                 830         
Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn
        835                 840                 845             
Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr
    850                 855                 860                 
Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr
865                 870                 875                 880 
Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp
                885                 890                 895     
Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala
            900                 905                 910         
Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu
        915                 920                 925             
Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr
    930                 935                 940                 
Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile
945                 950                 955                 960 
Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys
                965                 970                 975     
Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His
            980                 985                 990         
Ile Pro Gln Tyr Thr Lys Glu Lys Asn Pro Leu Met Tyr Leu Thr Gly
        995                 1000                1005            
Val Gln Thr Asp Lys Ala Gly Asp Ile Ser Cys Asn Ala Asp Ile Asn
    1010                1015                1020                
Pro Leu Lys Ile Gly Gln Thr Ser Ser Ser Val Ser Phe Lys Ser Glu
1025                1030                1035                1040
Asn Phe Arg His Thr Lys Glu Leu Asn Cys Arg Thr Ala Ser Cys Ser
                1045                1050                1055    
Asn Val Thr Cys Trp Leu Lys Asp Val His Met Lys Gly Glu Tyr Phe
            1060                1065                1070        
Val Asn Val Thr Thr Arg Ile Trp Asn Gly Thr Phe Ala Ser Ser Thr
        1075                1080                1085            
Phe Gln Thr Val Gln Leu Thr Ala Ala Ala Glu Ile Asn Thr Tyr Asn
    1090                1095                1100                
Pro Glu Ile Tyr Val Ile Glu Asp Asn Thr Val Thr Ile Pro Leu Met
1105                1110                1115                1120
Ile Met Lys Pro Asp Glu Lys Ala Glu Val Pro Thr Gly Val Ile Ile
                1125                1130                1135    
Gly Ser Ile Ile Ala Gly Ile Leu Leu Leu Leu Ala Leu Val Ala Ile
            1140                1145                1150        
Leu Trp Lys Leu Gly Phe Phe Lys Arg Lys Tyr Glu Lys Met Thr Lys
        1155                1160                1165            
Asn Pro Asp Glu Ile Asp Glu Thr Thr Glu Leu Ser Ser
    1170                1175                1180    


<210> 8890
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 8890
Leu Pro Leu Arg Leu Pro Thr Pro Arg Glu Leu Ala Ala Pro Gly Gly
 1               5                  10                  15      
Gln Arg Pro Asp Val Arg Gly Arg Cys Ala Pro Gly Pro Arg Gly Val
            20                  25                  30          
Thr Leu Ser Arg Leu Gln Thr Gln Arg Glu His Thr Ala Arg Met Gly
        35                  40                  45              
Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr Ile Ser
    50                  55                  60                  
Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val Ala Ala
65                  70                  75                  80  
Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro Gly His
                85                  90                  95      
Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu Leu Leu
            100                 105                 110         
Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly Gly Lys
        115                 120                 125             
Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr Arg His
    130                 135                 140                 
Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala Leu Cys
145                 150                 155                 160 
Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala Asp Glu
                165                 170                 175     
Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly Val Gly
            180                 185                 190         
Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser Trp Thr
        195                 200                 205             
Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly Gly Tyr
    210                 215                 220                 
Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His Val Ile
225                 230                 235                 240 
Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp Thr Tyr
                245                 250                 255     
Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn Ala Val
            260                 265                 270         
Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly Ser Arg
        275                 280                 285             
Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly Ser Lys
    290                 295                 300                 
His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu Thr Val
305                 310                 315                 320 
Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr His Gly
                325                 330                 335     
His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln Thr Glu
            340                 345                 350         
His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val Gln Asp
        355                 360                 365             
Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln Thr Lys
    370                 375                 380                 
Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly Lys Ile
385                 390                 395                 400 
Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly Val Asn
                405                 410                 415     
Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg Phe Ala
            420                 425                 430         
Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg Phe Leu
        435                 440                 445             
Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp Thr Asn
    450                 455                 460                 
Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser Trp Lys
465                 470                 475                 480 
Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met Tyr Gln
                485                 490                 495     
Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro Asn Gln
            500                 505                 510         
Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu Glu Ile
        515                 520                 525             
Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg Asn Ile
    530                 535                 540                 
Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg Asn His
545                 550                 555                 560 
Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile Lys Phe
                565                 570                 575     
Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu Lys His
            580                 585                 590         
Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His Leu Ala
        595                 600                 605             
Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr Ile Arg
    610                 615                 620                 
Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val His Gly
625                 630                 635                 640 
Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser Leu Gly
                645                 650                 655     
His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr Phe Asp
            660                 665                 670         
His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro Ser Asp
        675                 680                 685             
Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr Pro Gly
    690                 695                 700                 
Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr Phe Trp
705                 710                 715                 720 
Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala Gly Ser
                725                 730                 735     
Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr Gly Pro
            740                 745                 750         
Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro Leu Gly
        755                 760                 765             
Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly Met Ile
    770                 775                 780                 
Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp Lys Arg
785                 790                 795                 800 
Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln Asp Ala
                805                 810                 815     
Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe Ile Ala
            820                 825                 830         
Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp Val Trp
        835                 840                 845             
Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr Leu Ala
    850                 855                 860                 
Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu Ile Lys
865                 870                 875                 880 
Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu Met Met
                885                 890                 895     
Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly Arg Thr
            900                 905                 910         
Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu Tyr Asp
        915                 920                 925             
Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val Ala Leu
    930                 935                 940                 
Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn Ala Trp
945                 950                 955                 960 
Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu Asp Val
                965                 970                 975     
Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp Phe Asn
            980                 985                 990         
Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp Val Asp
        995                 1000                1005            
Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn Asp Lys
    1010                1015                1020                
Trp His Ser Leu Ala Ser Lys Ala Ala Ser Gly Pro Ser Gly
1025                1030                1035            


<210> 8891
<211> 1361
<212> PRT
<213> Homo sapiens

<400> 8891
Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr
 1               5                  10                  15      
Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val
            20                  25                  30          
Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro
        35                  40                  45              
Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu
    50                  55                  60                  
Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly
65                  70                  75                  80  
Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr
                85                  90                  95      
Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala
            100                 105                 110         
Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala
        115                 120                 125             
Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly
    130                 135                 140                 
Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser
145                 150                 155                 160 
Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly
                165                 170                 175     
Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His
            180                 185                 190         
Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp
        195                 200                 205             
Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn
    210                 215                 220                 
Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly
225                 230                 235                 240 
Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly
                245                 250                 255     
Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu
            260                 265                 270         
Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr
        275                 280                 285             
His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln
    290                 295                 300                 
Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val
305                 310                 315                 320 
Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln
                325                 330                 335     
Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly
            340                 345                 350         
Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly
        355                 360                 365             
Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg
    370                 375                 380                 
Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg
385                 390                 395                 400 
Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp
                405                 410                 415     
Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser
            420                 425                 430         
Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met
        435                 440                 445             
Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro
    450                 455                 460                 
Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu
465                 470                 475                 480 
Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg
                485                 490                 495     
Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg
            500                 505                 510         
Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile
        515                 520                 525             
Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu
    530                 535                 540                 
Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His
545                 550                 555                 560 
Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr
                565                 570                 575     
Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val
            580                 585                 590         
His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser
        595                 600                 605             
Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr
    610                 615                 620                 
Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro
625                 630                 635                 640 
Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr
                645                 650                 655     
Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr
            660                 665                 670         
Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala
        675                 680                 685             
Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr
    690                 695                 700                 
Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro
705                 710                 715                 720 
Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly
                725                 730                 735     
Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp
            740                 745                 750         
Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln
        755                 760                 765             
Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe
    770                 775                 780                 
Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp
785                 790                 795                 800 
Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr
                805                 810                 815     
Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu
            820                 825                 830         
Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu
        835                 840                 845             
Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly
    850                 855                 860                 
Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu
865                 870                 875                 880 
Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val
                885                 890                 895     
Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn
            900                 905                 910         
Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu
        915                 920                 925             
Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp
    930                 935                 940                 
Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp
945                 950                 955                 960 
Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn
                965                 970                 975     
Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp
            980                 985                 990         
Arg Gly Ala Ile Cys Ser Gly Cys Tyr Ala Gln Met Tyr Ile Gln Ala
        995                 1000                1005            
Tyr Lys Thr Ser Asn Leu Arg Met Lys Ile Ile Lys Asn Asp Phe Pro
    1010                1015                1020                
Ser His Pro Leu Tyr Leu Glu Gly Ala Leu Thr Arg Ser Thr His Tyr
1025                1030                1035                1040
Gln Gln Tyr Gln Pro Val Val Thr Leu Gln Lys Gly Tyr Thr Ile His
                1045                1050                1055    
Trp Asp Gln Thr Ala Pro Ala Glu Leu Ala Ile Trp Leu Ile Asn Phe
            1060                1065                1070        
Asn Lys Gly Asp Trp Ile Arg Val Gly Leu Cys Tyr Pro Arg Gly Thr
        1075                1080                1085            
Thr Phe Ser Ile Leu Ser Asp Val His Asn Arg Leu Leu Lys Gln Thr
    1090                1095                1100                
Ser Lys Thr Gly Val Phe Val Arg Thr Leu Gln Met Asp Lys Val Glu
1105                1110                1115                1120
Gln Ser Tyr Pro Gly Arg Ser His Tyr Tyr Trp Asp Glu Asp Ser Gly
                1125                1130                1135    
Leu Leu Phe Leu Lys Leu Lys Ala Gln Asn Glu Arg Glu Lys Phe Ala
            1140                1145                1150        
Phe Cys Ser Met Lys Gly Cys Glu Arg Ile Lys Ile Lys Ala Leu Ile
        1155                1160                1165            
Pro Lys Asn Ala Gly Val Ser Asp Cys Thr Ala Thr Ala Tyr Pro Lys
    1170                1175                1180                
Phe Thr Glu Arg Ala Val Val Asp Val Pro Met Pro Lys Lys Leu Phe
1185                1190                1195                1200
Gly Ser Gln Leu Lys Thr Lys Asp His Phe Leu Glu Val Lys Met Glu
                1205                1210                1215    
Ser Ser Lys Gln His Phe Phe His Leu Trp Asn Asp Phe Ala Tyr Ile
            1220                1225                1230        
Glu Val Asp Gly Lys Lys Tyr Pro Ser Ser Glu Asp Gly Ile Gln Val
        1235                1240                1245            
Val Val Ile Asp Gly Asn Gln Gly Arg Val Val Ser His Thr Ser Phe
    1250                1255                1260                
Arg Asn Ser Ile Leu Gln Gly Ile Pro Trp Gln Leu Phe Asn Tyr Val
1265                1270                1275                1280
Ala Thr Ile Pro Asp Asn Ser Ile Val Leu Met Ala Ser Lys Gly Arg
                1285                1290                1295    
Tyr Val Ser Arg Gly Pro Trp Thr Arg Val Leu Glu Lys Leu Gly Ala
            1300                1305                1310        
Asp Arg Gly Leu Lys Leu Lys Glu Gln Met Ala Phe Val Gly Phe Lys
        1315                1320                1325            
Gly Ser Phe Arg Pro Ile Trp Val Thr Leu Asp Thr Glu Asp His Lys
    1330                1335                1340                
Ala Lys Ile Phe Gln Val Val Pro Ile Pro Val Val Lys Lys Lys Lys
1345                1350                1355                1360
Leu
    


<210> 8892
<211> 197
<212> PRT
<213> Homo sapiens

<400> 8892
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly
 1               5                  10                  15      
Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn
            20                  25                  30          
Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr
        35                  40                  45              
Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg
    50                  55                  60                  
Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys
65                  70                  75                  80  
Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr
                85                  90                  95      
Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser
            100                 105                 110         
Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val
        115                 120                 125             
Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr
    130                 135                 140                 
Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr
145                 150                 155                 160 
Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val
                165                 170                 175     
Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg
            180                 185                 190         
Asn Tyr His Thr Leu
        195         


<210> 8893
<211> 189
<212> PRT
<213> Homo sapiens

<400> 8893
Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly
 1               5                  10                  15      
Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn
            20                  25                  30          
Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr
        35                  40                  45              
Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg
    50                  55                  60                  
Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys
65                  70                  75                  80  
Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr
                85                  90                  95      
Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser
            100                 105                 110         
Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val
        115                 120                 125             
Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr
    130                 135                 140                 
Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr
145                 150                 155                 160 
Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Glu Ile
                165                 170                 175     
Arg Cys His Thr Arg Asn Tyr Ile Pro Asp Leu Lys Lys
            180                 185                 


<210> 8894
<211> 698
<212> PRT
<213> Homo sapiens

<400> 8894
Met Glu Glu Asn Val Phe Trp Glu Cys Lys Ala Asn Gly Arg Pro Lys
 1               5                  10                  15      
Pro Thr Tyr Lys Trp Leu Lys Asn Gly Glu Pro Leu Leu Thr Arg Asp
            20                  25                  30          
Arg Ile Gln Ile Glu Gln Gly Thr Leu Asn Ile Thr Ile Val Asn Leu
        35                  40                  45              
Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys His Gly Val
    50                  55                  60                  
Ile Phe Ser Asn Ala Glu Leu Ser Val Ile Ala Val Gly Pro Asp Phe
65                  70                  75                  80  
Ser Arg Thr Leu Leu Lys Arg Val Thr Leu Val Lys Val Gly Gly Glu
                85                  90                  95      
Val Val Ile Glu Cys Lys Pro Lys Ala Ser Pro Lys Pro Val Tyr Thr
            100                 105                 110         
Trp Lys Lys Gly Arg Asp Ile Leu Lys Glu Asn Glu Arg Ile Thr Ile
        115                 120                 125             
Ser Glu Asp Gly Asn Leu Arg Ile Ile Asn Val Thr Lys Ser Asp Ala
    130                 135                 140                 
Gly Ser Tyr Thr Cys Ile Ala Thr Asn His Phe Gly Thr Ala Ser Ser
145                 150                 155                 160 
Thr Gly Asn Leu Val Val Lys Asp Pro Thr Arg Val Met Val Pro Pro
                165                 170                 175     
Ser Ser Met Asp Val Thr Val Gly Glu Ser Ile Val Leu Pro Cys Gln
            180                 185                 190         
Val Thr His Asp His Ser Leu Asp Ile Val Phe Thr Trp Ser Phe Asn
        195                 200                 205             
Gly His Leu Ile Asp Phe Asp Arg Asp Gly Asp His Phe Glu Arg Val
    210                 215                 220                 
Gly Gly Gln Asp Ser Ala Gly Asp Leu Met Ile Arg Asn Ile Gln Leu
225                 230                 235                 240 
Lys His Ala Gly Lys Tyr Val Cys Met Val Gln Thr Ser Val Asp Arg
                245                 250                 255     
Leu Ser Ala Ala Ala Asp Leu Ile Val Arg Gly Pro Pro Gly Pro Pro
            260                 265                 270         
Glu Ala Val Thr Ile Asp Glu Ile Thr Asp Thr Thr Ala Gln Leu Ser
        275                 280                 285             
Trp Arg Pro Gly Pro Asp Asn His Ser Pro Ile Thr Met Tyr Val Ile
    290                 295                 300                 
Gln Ala Arg Thr Pro Phe Ser Val Gly Trp Gln Ala Val Ser Thr Val
305                 310                 315                 320 
Pro Glu Leu Ile Asp Gly Lys Thr Phe Thr Ala Thr Val Val Gly Leu
                325                 330                 335     
Asn Pro Trp Val Glu Tyr Glu Phe Arg Thr Val Ala Ala Asn Val Ile
            340                 345                 350         
Gly Ile Gly Glu Pro Ser Arg Pro Ser Glu Lys Arg Arg Thr Glu Glu
        355                 360                 365             
Ala Leu Pro Glu Val Thr Pro Ala Asn Val Ser Gly Gly Gly Gly Ser
    370                 375                 380                 
Lys Ser Glu Leu Val Ile Thr Trp Glu Thr Val Pro Glu Glu Leu Gln
385                 390                 395                 400 
Asn Gly Arg Gly Phe Gly Tyr Val Val Ala Phe Arg Pro Tyr Gly Lys
                405                 410                 415     
Met Ile Trp Met Leu Thr Val Leu Ala Ser Ala Asp Ala Ser Arg Tyr
            420                 425                 430         
Val Phe Arg Asn Glu Ser Val His Pro Phe Ser Pro Phe Glu Val Lys
        435                 440                 445             
Val Gly Val Phe Asn Asn Lys Gly Glu Gly Pro Phe Ser Pro Thr Thr
    450                 455                 460                 
Val Val Tyr Ser Ala Glu Glu Glu Pro Thr Lys Pro Pro Ala Ser Ile
465                 470                 475                 480 
Phe Ala Arg Ser Leu Ser Ala Thr Asp Ile Glu Val Phe Trp Ala Ser
                485                 490                 495     
Pro Leu Glu Lys Asn Arg Gly Arg Ile Gln Gly Tyr Glu Val Lys Tyr
            500                 505                 510         
Trp Arg His Glu Asp Lys Glu Glu Asn Ala Arg Lys Ile Arg Thr Val
        515                 520                 525             
Gly Asn Gln Thr Ser Thr Lys Ile Thr Asn Leu Lys Gly Ser Val Leu
    530                 535                 540                 
Tyr His Leu Ala Val Lys Ala Tyr Asn Ser Ala Gly Thr Gly Pro Ser
545                 550                 555                 560 
Ser Ala Thr Val Asn Val Thr Thr Arg Lys Pro Pro Pro Ser Gln Pro
                565                 570                 575     
Pro Gly Asn Ile Ile Trp Asn Ser Ser Asp Ser Lys Ile Ile Leu Asn
            580                 585                 590         
Trp Asp Gln Val Lys Ala Leu Asp Asn Glu Ser Glu Val Lys Gly Tyr
        595                 600                 605             
Lys Val Leu Tyr Arg Trp Asn Arg Gln Ser Ser Thr Ser Val Ile Glu
    610                 615                 620                 
Thr Asn Lys Thr Ser Val Glu Leu Ser Leu Pro Phe Asp Glu Asp Tyr
625                 630                 635                 640 
Ile Ile Glu Ile Lys Pro Phe Ser Asp Gly Gly Asp Gly Ser Ser Ser
                645                 650                 655     
Glu Gln Ile Arg Ile Pro Lys Ile Ser Asn Ala Tyr Ala Arg Gly Ser
            660                 665                 670         
Gly Ala Ser Thr Ser Asn Ala Cys Thr Leu Ser Ala Ile Ser Thr Ile
        675                 680                 685             
Met Ile Ser Leu Thr Ala Arg Ser Ser Leu
    690                 695             


<210> 8895
<211> 1026
<212> PRT
<213> Homo sapiens

<400> 8895
Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys
 1               5                  10                  15      
Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro
            20                  25                  30          
Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu
        35                  40                  45              
Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu
    50                  55                  60                  
Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val
65                  70                  75                  80  
Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly
                85                  90                  95      
Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg
            100                 105                 110         
Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr
        115                 120                 125             
Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys
    130                 135                 140                 
Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn
145                 150                 155                 160 
Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr
                165                 170                 175     
Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr
            180                 185                 190         
Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro
        195                 200                 205             
Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu
    210                 215                 220                 
Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys Gly
225                 230                 235                 240 
Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr
                245                 250                 255     
Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg
            260                 265                 270         
Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu
        275                 280                 285             
Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn
    290                 295                 300                 
Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile Gln
305                 310                 315                 320 
Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu
                325                 330                 335     
Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn
            340                 345                 350         
Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr
        355                 360                 365             
Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys
    370                 375                 380                 
Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser
385                 390                 395                 400 
Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val
                405                 410                 415     
Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys
            420                 425                 430         
Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu
        435                 440                 445             
Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile
    450                 455                 460                 
Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr
465                 470                 475                 480 
Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys Asp
                485                 490                 495     
Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly
            500                 505                 510         
Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp
        515                 520                 525             
Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp Arg
    530                 535                 540                 
Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp
545                 550                 555                 560 
Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys
                565                 570                 575     
Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu Ile
            580                 585                 590         
Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile
        595                 600                 605             
Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His
    610                 615                 620                 
Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val
625                 630                 635                 640 
Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr
                645                 650                 655     
Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe
            660                 665                 670         
Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro
        675                 680                 685             
Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala
    690                 695                 700                 
Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp
705                 710                 715                 720 
Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val
                725                 730                 735     
Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val Leu
            740                 745                 750         
Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val His
        755                 760                 765             
Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly
    770                 775                 780                 
Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu Glu
785                 790                 795                 800 
Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr
                805                 810                 815     
Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg
            820                 825                 830         
Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu
        835                 840                 845             
Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile
    850                 855                 860                 
Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr
865                 870                 875                 880 
Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr Thr
                885                 890                 895     
Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser
            900                 905                 910         
Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp
        915                 920                 925             
Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg
    930                 935                 940                 
Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu
945                 950                 955                 960 
Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser
                965                 970                 975     
Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile
            980                 985                 990         
Ser Asn Ala Tyr Ala Arg Gly Ser Gly Ala Ser Thr Ser Asn Ala Cys
        995                 1000                1005            
Thr Leu Ser Ala Ile Ser Thr Ile Met Ile Ser Leu Thr Ala Arg Ser
    1010                1015                1020                
Ser Leu
1025    


<210> 8896
<211> 204
<212> PRT
<213> Homo sapiens

<400> 8896
Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu
 1               5                  10                  15      
Gln Gly Ala Trp Pro His Glu Gly Leu Tyr Glu Lys Pro Ser Leu Ser
            20                  25                  30          
Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser Val Thr Leu Ser
        35                  40                  45              
Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly
    50                  55                  60                  
Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys Val Asn Gly Thr
65                  70                  75                  80  
Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr
                85                  90                  95      
Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu Trp Ser Asn Ser
            100                 105                 110         
Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Asn Ser Trp
        115                 120                 125             
Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn Pro Arg His Leu
    130                 135                 140                 
His Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu
145                 150                 155                 160 
Leu Phe Phe Leu Leu His Arg Trp Cys Cys Asn Lys Lys Asn Ala Val
                165                 170                 175     
Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val Asn Arg Glu Asp
            180                 185                 190         
Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala
        195                 200                 


<210> 8897
<211> 436
<212> PRT
<213> Homo sapiens

<400> 8897
Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Leu Phe Leu Val
 1               5                  10                  15      
Gln Arg Ala Gly Pro His Met Gly Gly Gln Asp Lys Pro Phe Leu Ser
            20                  25                  30          
Ala Trp Pro Ser Ala Val Val Pro Arg Gly Gly His Val Thr Leu Arg
        35                  40                  45              
Cys His Tyr Arg His Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp
    50                  55                  60                  
Arg Ile His Ile Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe
65                  70                  75                  80  
Asn Met Ser Pro Val Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg
                85                  90                  95      
Gly Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro
            100                 105                 110         
Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala
        115                 120                 125             
His Pro Gly Pro Leu Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys
    130                 135                 140                 
Trp Ser Asp Ile Met Phe Glu His Phe Phe Leu His Lys Glu Gly Ile
145                 150                 155                 160 
Ser Lys Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser
                165                 170                 175     
Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly Thr
            180                 185                 190         
Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser Ala
        195                 200                 205             
Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro
    210                 215                 220                 
Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser Val
225                 230                 235                 240 
Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser
                245                 250                 255     
Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys Val
            260                 265                 270         
Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly
        275                 280                 285             
Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu Trp
    290                 295                 300                 
Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser
305                 310                 315                 320 
Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn Pro
                325                 330                 335     
Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe
            340                 345                 350         
Ile Leu Leu Leu Phe Phe Leu Leu His Arg Trp Cys Cys Asn Lys Lys
        355                 360                 365             
Asn Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val Asn
    370                 375                 380                 
Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln
385                 390                 395                 400 
Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln
                405                 410                 415     
Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro
            420                 425                 430         
Asn Ala Glu Pro
        435     


<210> 8898
<211> 243
<212> PRT
<213> Homo sapiens

<400> 8898
Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu
 1               5                  10                  15      
Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu
            20                  25                  30          
Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln
        35                  40                  45              
Cys Trp Ser Asp Val Arg Phe Gln His Phe Leu Leu His Arg Glu Gly
    50                  55                  60                  
Lys Phe Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val
65                  70                  75                  80  
Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly
                85                  90                  95      
Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser
            100                 105                 110         
Ala Pro Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Asn
        115                 120                 125             
Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn Pro Arg
    130                 135                 140                 
His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile
145                 150                 155                 160 
Leu Leu Leu Phe Phe Leu Leu His Arg Trp Cys Cys Asn Lys Lys Asn
                165                 170                 175     
Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val Asn Arg
            180                 185                 190         
Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu
        195                 200                 205             
Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg
    210                 215                 220                 
Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro Asn
225                 230                 235                 240 
Ala Glu Pro
            


<210> 8899
<211> 341
<212> PRT
<213> Homo sapiens

<400> 8899
Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu
 1               5                  10                  15      
Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu
            20                  25                  30          
Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln
        35                  40                  45              
Cys Trp Ser Asp Val Arg Phe Gln His Phe Leu Leu His Arg Glu Gly
    50                  55                  60                  
Lys Phe Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val
65                  70                  75                  80  
Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly
                85                  90                  95      
Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser
            100                 105                 110         
Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys
        115                 120                 125             
Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser
    130                 135                 140                 
Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu
145                 150                 155                 160 
Ser Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys
                165                 170                 175     
Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His
            180                 185                 190         
Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu
        195                 200                 205             
Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro
    210                 215                 220                 
Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn
225                 230                 235                 240 
Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu
                245                 250                 255     
Phe Ile Leu Leu Leu Phe Phe Leu Leu His Arg Trp Cys Cys Asn Lys
            260                 265                 270         
Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val
        275                 280                 285             
Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala
    290                 295                 300                 
Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser
305                 310                 315                 320 
Gln Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu
                325                 330                 335     
Pro Asn Ala Glu Pro
            340     


<210> 8900
<211> 510
<212> PRT
<213> Homo sapiens

<400> 8900
Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly
            20                  25                  30          
Glu Leu Gly Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala
        35                  40                  45              
Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln
    50                  55                  60                  
Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala
65                  70                  75                  80  
Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly
                85                  90                  95      
Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val
            100                 105                 110         
Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg
        115                 120                 125             
Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg
    130                 135                 140                 
Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu
145                 150                 155                 160 
Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser
                165                 170                 175     
Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser
            180                 185                 190         
Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe
        195                 200                 205             
His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val
    210                 215                 220                 
Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu
225                 230                 235                 240 
His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln
                245                 250                 255     
Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser
            260                 265                 270         
Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro
        275                 280                 285             
Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro
    290                 295                 300                 
Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu
305                 310                 315                 320 
Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln
                325                 330                 335     
Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val
            340                 345                 350         
Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val
        355                 360                 365             
Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln
    370                 375                 380                 
Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg
385                 390                 395                 400 
Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val
                405                 410                 415     
Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser
            420                 425                 430         
Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu
        435                 440                 445             
Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly
    450                 455                 460                 
Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln
465                 470                 475                 480 
Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro
                485                 490                 495     
Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val
            500                 505                 510 


<210> 8901
<211> 2322
<212> PRT
<213> Homo sapiens

<400> 8901
Met Gln Ser Gly Arg Gly Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu
 1               5                  10                  15      
Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe
            20                  25                  30          
Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp
        35                  40                  45              
Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu
    50                  55                  60                  
Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser
65                  70                  75                  80  
Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu
                85                  90                  95      
Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val
            100                 105                 110         
Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe
        115                 120                 125             
Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr
    130                 135                 140                 
Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg
145                 150                 155                 160 
Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn
                165                 170                 175     
Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys
            180                 185                 190         
Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly
        195                 200                 205             
Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly
    210                 215                 220                 
Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala
225                 230                 235                 240 
Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe
                245                 250                 255     
Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu
            260                 265                 270         
Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser
        275                 280                 285             
Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro
    290                 295                 300                 
Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly
305                 310                 315                 320 
Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln
                325                 330                 335     
Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu
            340                 345                 350         
Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg
        355                 360                 365             
Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu
    370                 375                 380                 
Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr
385                 390                 395                 400 
Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val
                405                 410                 415     
Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu
            420                 425                 430         
Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu
        435                 440                 445             
Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg
    450                 455                 460                 
Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala His Tyr Gly Glu
465                 470                 475                 480 
Leu Glu Leu Asp Ile Leu Gly Ala Gln Ala Arg Lys Met Phe Thr Leu
                485                 490                 495     
Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu
            500                 505                 510         
Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val
        515                 520                 525             
Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile
    530                 535                 540                 
Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly
545                 550                 555                 560 
Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu
                565                 570                 575     
Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe
            580                 585                 590         
Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln
        595                 600                 605             
Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly
    610                 615                 620                 
Ser Leu Val Tyr Val His Cys Gly Gly Pro Ala Gln Asp Leu Thr Phe
625                 630                 635                 640 
Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val
                645                 650                 655     
Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg
            660                 665                 670         
Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val
        675                 680                 685             
Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr
    690                 695                 700                 
Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys His Ser Thr Gly Gly Val
705                 710                 715                 720 
Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val
                725                 730                 735     
Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala
            740                 745                 750         
Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu
        755                 760                 765             
Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val
    770                 775                 780                 
Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu
785                 790                 795                 800 
Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro
                805                 810                 815     
Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly
            820                 825                 830         
Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr
        835                 840                 845             
Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg
    850                 855                 860                 
Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro
865                 870                 875                 880 
Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp
                885                 890                 895     
Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly
            900                 905                 910         
Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn
        915                 920                 925             
Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg Leu Gly Arg
    930                 935                 940                 
Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe
945                 950                 955                 960 
Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp
                965                 970                 975     
Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly
            980                 985                 990         
Glu Ser Ser Gly Asp Met Ala Trp Glu Glu Val Arg Gly Val Phe Arg
        995                 1000                1005            
Val Ala Ile Gln Pro Val Asn Asp His Ala Pro Val Gln Thr Ile Ser
    1010                1015                1020                
Arg Ile Phe His Val Ala Arg Gly Gly Arg Arg Leu Leu Thr Thr Asp
1025                1030                1035                1040
Asp Val Ala Phe Ser Asp Ala Asp Ser Gly Phe Ala Asp Ala Gln Leu
                1045                1050                1055    
Val Leu Thr Arg Lys Asp Leu Leu Phe Gly Ser Ile Val Ala Val Asp
            1060                1065                1070        
Glu Pro Thr Arg Pro Ile Tyr Arg Phe Thr Gln Glu Asp Leu Arg Lys
        1075                1080                1085            
Arg Arg Val Leu Phe Val His Ser Gly Ala Asp Arg Gly Trp Ile Gln
    1090                1095                1100                
Leu Gln Val Ser Asp Gly Gln His Gln Ala Thr Ala Leu Leu Glu Val
1105                1110                1115                1120
Gln Ala Ser Glu Pro Tyr Leu Arg Val Ala Asn Gly Ser Ser Leu Val
                1125                1130                1135    
Val Pro Gln Gly Gly Gln Gly Thr Ile Asp Thr Ala Val Leu His Leu
            1140                1145                1150        
Asp Thr Asn Leu Asp Ile Arg Ser Gly Asp Glu Val His Tyr His Val
        1155                1160                1165            
Thr Ala Gly Pro Arg Trp Gly Gln Leu Val Arg Ala Gly Gln Pro Ala
    1170                1175                1180                
Thr Ala Phe Ser Gln Gln Asp Leu Leu Asp Gly Ala Val Leu Tyr Ser
1185                1190                1195                1200
His Asn Gly Ser Leu Ser Pro Glu Asp Thr Met Ala Phe Ser Val Glu
                1205                1210                1215    
Ala Gly Pro Val His Thr Asp Ala Thr Leu Gln Val Thr Ile Ala Leu
            1220                1225                1230        
Glu Gly Pro Leu Ala Pro Leu Lys Leu Val Arg His Lys Lys Ile Tyr
        1235                1240                1245            
Val Phe Gln Gly Glu Ala Ala Glu Ile Arg Arg Asp Gln Leu Glu Ala
    1250                1255                1260                
Ala Gln Glu Ala Val Pro Pro Ala Asp Ile Val Phe Ser Val Lys Ser
1265                1270                1275                1280
Pro Pro Ser Ala Gly Tyr Leu Val Met Val Ser Arg Gly Ala Leu Ala
                1285                1290                1295    
Asp Glu Pro Pro Ser Leu Asp Pro Val Gln Ser Phe Ser Gln Glu Ala
            1300                1305                1310        
Val Asp Thr Gly Arg Val Leu Tyr Leu His Ser Arg Pro Glu Ala Trp
        1315                1320                1325            
Ser Asp Ala Phe Ser Leu Asp Val Ala Ser Gly Leu Gly Ala Pro Leu
    1330                1335                1340                
Glu Gly Val Leu Val Glu Leu Glu Val Leu Pro Ala Ala Ile Pro Leu
1345                1350                1355                1360
Glu Ala Gln Asn Phe Ser Val Pro Glu Gly Gly Ser Leu Thr Leu Ala
                1365                1370                1375    
Pro Pro Leu Leu Arg Val Ser Gly Pro Tyr Phe Pro Thr Leu Leu Gly
            1380                1385                1390        
Leu Ser Leu Gln Val Leu Glu Pro Pro Gln His Gly Pro Leu Gln Lys
        1395                1400                1405            
Glu Asp Gly Pro Gln Ala Arg Thr Leu Ser Ala Phe Ser Trp Arg Met
    1410                1415                1420                
Val Glu Glu Gln Leu Ile Arg Tyr Val His Asp Gly Ser Glu Thr Leu
1425                1430                1435                1440
Thr Asp Ser Phe Val Leu Met Ala Asn Ala Ser Glu Met Asp Arg Gln
                1445                1450                1455    
Ser His Pro Val Ala Phe Thr Val Thr Val Leu Pro Val Asn Asp Gln
            1460                1465                1470        
Pro Pro Ile Leu Thr Thr Asn Thr Gly Leu Gln Met Trp Glu Gly Ala
        1475                1480                1485            
Thr Ala Pro Ile Pro Ala Glu Ala Leu Arg Ser Thr Asp Gly Asp Ser
    1490                1495                1500                
Gly Ser Glu Asp Leu Val Tyr Thr Ile Glu Gln Pro Ser Asn Gly Arg
1505                1510                1515                1520
Val Val Leu Arg Gly Ala Pro Gly Thr Glu Val Arg Ser Phe Thr Gln
                1525                1530                1535    
Ala Gln Leu Asp Gly Gly Leu Val Leu Phe Ser His Arg Gly Thr Leu
            1540                1545                1550        
Asp Gly Gly Phe Pro Phe Arg Leu Ser Asp Gly Glu His Thr Ser Pro
        1555                1560                1565            
Gly His Phe Phe Arg Val Thr Ala Gln Lys Gln Val Leu Leu Ser Leu
    1570                1575                1580                
Lys Gly Ser Gln Thr Leu Thr Val Cys Pro Gly Ser Val Gln Pro Leu
1585                1590                1595                1600
Ser Ser Gln Thr Leu Arg Ala Ser Ser Ser Ala Gly Thr Asp Pro Gln
                1605                1610                1615    
Leu Leu Leu Tyr Arg Val Val Arg Gly Pro Gln Leu Gly Arg Leu Phe
            1620                1625                1630        
His Ala Gln Gln Asp Ser Thr Gly Glu Ala Leu Val Asn Phe Thr Gln
        1635                1640                1645            
Ala Glu Val Tyr Ala Gly Asn Ile Leu Tyr Glu His Glu Met Pro Pro
    1650                1655                1660                
Glu Pro Phe Trp Glu Ala His Asp Thr Leu Glu Leu Gln Leu Ser Ser
1665                1670                1675                1680
Pro Pro Ala Arg Asp Val Ala Ala Thr Leu Ala Val Ala Val Ser Phe
                1685                1690                1695    
Glu Ala Ala Cys Pro Gln Arg Pro Ser His Leu Trp Lys Asn Lys Gly
            1700                1705                1710        
Leu Trp Val Pro Glu Gly Gln Arg Ala Arg Ile Thr Val Ala Ala Leu
        1715                1720                1725            
Asp Ala Ser Asn Leu Leu Ala Ser Val Pro Ser Pro Gln Arg Ser Glu
    1730                1735                1740                
His Asp Val Leu Phe Gln Val Thr Gln Phe Pro Ser Arg Gly Gln Leu
1745                1750                1755                1760
Leu Val Ser Glu Glu Pro Leu His Ala Gly Gln Pro His Phe Leu Gln
                1765                1770                1775    
Ser Gln Leu Ala Ala Gly Gln Leu Val Tyr Ala His Gly Gly Gly Gly
            1780                1785                1790        
Thr Gln Gln Asp Gly Phe His Phe Arg Ala His Leu Gln Gly Pro Ala
        1795                1800                1805            
Gly Ala Ser Val Ala Gly Pro Gln Thr Ser Glu Ala Phe Ala Ile Thr
    1810                1815                1820                
Val Arg Asp Val Asn Glu Arg Pro Pro Gln Pro Gln Ala Ser Val Pro
1825                1830                1835                1840
Leu Arg Leu Thr Arg Gly Ser Arg Ala Pro Ile Ser Arg Ala Gln Leu
                1845                1850                1855    
Ser Val Val Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu Tyr Glu Val
            1860                1865                1870        
Gln Arg Ala Pro His Asn Gly Phe Leu Ser Leu Val Gly Gly Gly Leu
        1875                1880                1885            
Gly Pro Val Thr Arg Phe Thr Gln Ala Asp Val Asp Ser Gly Arg Leu
    1890                1895                1900                
Ala Phe Val Ala Asn Gly Ser Ser Val Ala Gly Ile Phe Gln Leu Ser
1905                1910                1915                1920
Met Ser Asp Gly Ala Ser Pro Pro Leu Pro Met Ser Leu Ala Val Asp
                1925                1930                1935    
Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Arg Ala Pro Leu Glu Val
            1940                1945                1950        
Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln Leu Arg Val
        1955                1960                1965            
Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu Ile Gln Gly
    1970                1975                1980                
Pro Gln Tyr Gly His Leu Leu Val Gly Gly Arg Pro Thr Ser Ala Phe
1985                1990                1995                2000
Ser Gln Phe Gln Ile Asp Gln Gly Glu Val Val Phe Ala Phe Thr Asn
                2005                2010                2015    
Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu Ala Arg Gly
            2020                2025                2030        
Val Asn Ala Ser Ala Val Val Asn Val Thr Val Arg Ala Leu Leu His
        2035                2040                2045            
Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu Arg Leu Asp
    2050                2055                2060                
Pro Thr Val Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr Gly Ser Val
2065                2070                2075                2080
Pro Arg Phe Arg Leu Leu Glu Gly Pro Arg His Gly Arg Val Val Arg
                2085                2090                2095    
Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu Val Glu Gln
            2100                2105                2110        
Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu Glu Val Gly
        2115                2120                2125            
Arg Pro Glu Gly Arg Ala Pro Gly Pro Ala Gly Asp Ser Leu Thr Leu
    2130                2135                2140                
Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val Ala Ser Leu Asp Phe
2145                2150                2155                2160
Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val Ala Leu Leu
                2165                2170                2175    
Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser
            2180                2185                2190        
Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala
        2195                2200                2205            
Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn Met Phe Ser
    2210                2215                2220                
Val Ile Ile Pro Met Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu
2225                2230                2235                2240
Pro Leu Leu Phe Tyr Leu Arg Lys Arg Asn Lys Thr Gly Lys His Asp
                2245                2250                2255    
Val Gln Val Leu Thr Ala Lys Pro Arg Asn Gly Leu Ala Gly Asp Thr
            2260                2265                2270        
Glu Thr Phe Arg Lys Val Glu Pro Gly Gln Ala Ile Pro Leu Thr Ala
        2275                2280                2285            
Val Pro Gly Gln Gly Pro Pro Pro Gly Gly Gln Pro Asp Pro Glu Leu
    2290                2295                2300                
Leu Gln Phe Cys Arg Thr Pro Asn Pro Ala Leu Lys Asn Gly Gln Tyr
2305                2310                2315                2320
Trp Val
        


<210> 8902
<211> 374
<212> PRT
<213> Homo sapiens

<400> 8902
Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln
 1               5                  10                  15      
Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser
            20                  25                  30          
Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu
        35                  40                  45              
Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln
    50                  55                  60                  
Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser
65                  70                  75                  80  
Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile
                85                  90                  95      
Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg
            100                 105                 110         
Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys
        115                 120                 125             
Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe
    130                 135                 140                 
Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile
145                 150                 155                 160 
Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr
                165                 170                 175     
Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro
            180                 185                 190         
Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val
        195                 200                 205             
Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln
    210                 215                 220                 
Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn
225                 230                 235                 240 
Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly
                245                 250                 255     
Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg
            260                 265                 270         
Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro
        275                 280                 285             
Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu
    290                 295                 300                 
Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys
305                 310                 315                 320 
Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys
                325                 330                 335     
Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys
            340                 345                 350         
Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys
        355                 360                 365             
Glu Pro Gln Gly Ala Thr
    370                 


<210> 8903
<211> 374
<212> PRT
<213> Homo sapiens

<400> 8903
Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln
 1               5                  10                  15      
Val Asp Thr Thr Lys Ala Val Ile Ser Leu Gln Pro Pro Trp Val Ser
            20                  25                  30          
Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu
        35                  40                  45              
Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln
    50                  55                  60                  
Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser
65                  70                  75                  80  
Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile
                85                  90                  95      
Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg
            100                 105                 110         
Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys
        115                 120                 125             
Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe
    130                 135                 140                 
Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile
145                 150                 155                 160 
Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr
                165                 170                 175     
Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro
            180                 185                 190         
Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val
        195                 200                 205             
Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln
    210                 215                 220                 
Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn
225                 230                 235                 240 
Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly
                245                 250                 255     
Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg
            260                 265                 270         
Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro
        275                 280                 285             
Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu
    290                 295                 300                 
Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys
305                 310                 315                 320 
Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys
                325                 330                 335     
Val Thr Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys
            340                 345                 350         
Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys
        355                 360                 365             
Glu Pro Gln Gly Ala Thr
    370                 


<210> 8904
<211> 565
<212> PRT
<213> Homo sapiens

<400> 8904
Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val
 1               5                  10                  15      
Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln
            20                  25                  30          
Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser
        35                  40                  45              
Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro
    50                  55                  60                  
Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln
65                  70                  75                  80  
Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Thr Pro Thr Pro Ser Leu
                85                  90                  95      
Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu
            100                 105                 110         
Leu Pro Ala Gly Leu Val Ser Phe Val Glu Val Val Ser Leu Trp Phe
        115                 120                 125             
Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn
    130                 135                 140                 
Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln
145                 150                 155                 160 
Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu
                165                 170                 175     
Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly
            180                 185                 190         
Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr
        195                 200                 205             
Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu
    210                 215                 220                 
Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly
225                 230                 235                 240 
Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr
                245                 250                 255     
Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg
            260                 265                 270         
Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly
        275                 280                 285             
Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu
    290                 295                 300                 
Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr
305                 310                 315                 320 
Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln
                325                 330                 335     
Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg
            340                 345                 350         
Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn
        355                 360                 365             
Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp
    370                 375                 380                 
Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro
385                 390                 395                 400 
Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala
                405                 410                 415     
Phe Asn Trp Asn Asp Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys
            420                 425                 430         
Gln Phe Ala Ser Leu Ala Phe Val Ile His Ser Thr Arg Leu Ser Phe
        435                 440                 445             
Cys Leu Arg Met Pro Asn Asp Pro Glu Lys Asn Thr Asp His Asp Ile
    450                 455                 460                 
Lys Arg Pro Trp Gln Arg Asn Arg Asp Tyr Cys Asp Thr Arg Phe Cys
465                 470                 475                 480 
Thr Ser Lys Gly Ile Pro Val Val Ser Phe Gly Lys Arg Thr Lys Pro
                485                 490                 495     
Asp Leu Gln Tyr Ala Cys Tyr Leu Trp Arg Phe Ile Trp Gly Thr Tyr
            500                 505                 510         
Phe Ser Leu Ile Gly Cys Cys His Gly His Asp Cys Cys Tyr Thr Gly
        515                 520                 525             
Ala Glu Glu Ala Gly Cys Ser Pro Lys Thr Glu Arg Tyr Ser Trp Gln
    530                 535                 540                 
Cys Val Asn Gln Ser Val Leu Cys Gly Pro Ser Gly Asn His Thr Asp
545                 550                 555                 560 
Ile Glu Thr Lys Gln
                565 


<210> 8905
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8905
Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val
 1               5                  10                  15      
Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr
            20                  25                  30          
Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val
        35                  40                  45              
Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro
    50                  55                  60                  
Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val
65                  70                  75                  80  
Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu
                85                  90                  95      
Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly
            100                 105                 110         
Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn
        115                 120                 125             
Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn
    130                 135                 140                 
Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp
145                 150                 155                 160 
Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln
                165                 170                 175     
Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu
            180                 185                 190         
Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr
        195                 200                 205             
Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile
    210                 215                 220                 
Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro
225                 230                 235                 240 
Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg
                245                 250                 255     
Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly
            260                 265                 270         
Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr
        275                 280                 285             
Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro
    290                 295                 300                 
Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn
305                 310                 315                 320 
Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile
                325                 330                 335     
Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu
            340                 345                 350         
Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro
        355                 360                 365             
Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser
    370                 375                 380                 
Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile
385                 390                 395                 400 
Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala
                405                 410                 415     
Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe
            420                 425                 430         
Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile
        435                 440                 445             
Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu
    450                 455                 460                 
Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu
465                 470                 475                 480 
Thr Val Leu Val Ser Pro Arg Phe Thr Ala Gly Pro Leu Ser Ser Pro
                485                 490                 495     
Gly Pro Thr Val Val Arg His Pro Glu Gly Phe Cys Pro Arg Asp Leu
            500                 505                 510         
Ser Asn Gln Gly Arg Arg His Pro Gln Ile Pro Glu Leu Cys Leu Leu
        515                 520                 525             
Val Tyr
    530 


<210> 8906
<211> 832
<212> PRT
<213> Homo sapiens

<400> 8906
Met Ala Ser Ala Val Arg Gly Ser Arg Pro Trp Pro Arg Leu Gly Leu
 1               5                  10                  15      
Gln Leu Gln Phe Ala Ala Leu Leu Leu Gly Thr Leu Ser Pro Gln Val
            20                  25                  30          
His Thr Leu Arg Pro Glu Asn Leu Leu Leu Val Ser Thr Leu Asp Gly
        35                  40                  45              
Ser Leu His Ala Leu Ser Lys Gln Thr Gly Asp Leu Lys Trp Thr Leu
    50                  55                  60                  
Arg Asp Asp Pro Val Ile Glu Gly Pro Met Tyr Val Thr Glu Met Ala
65                  70                  75                  80  
Phe Leu Ser Asp Pro Ala Asp Gly Ser Leu Tyr Ile Leu Gly Thr Gln
                85                  90                  95      
Lys Gln Gln Gly Leu Met Lys Leu Pro Phe Thr Ile Pro Glu Leu Val
            100                 105                 110         
His Ala Ser Pro Cys Arg Ser Ser Asp Gly Val Phe Tyr Thr Gly Arg
        115                 120                 125             
Lys Gln Asp Ala Trp Phe Val Val Asp Pro Glu Ser Gly Glu Thr Gln
    130                 135                 140                 
Met Thr Leu Thr Thr Glu Gly Pro Ser Thr Pro Arg Leu Tyr Ile Gly
145                 150                 155                 160 
Arg Thr Gln Tyr Thr Val Thr Met His Asp Pro Arg Ala Pro Ala Leu
                165                 170                 175     
Arg Trp Asn Thr Thr Tyr Arg Arg Tyr Ser Ala Pro Pro Met Asp Gly
            180                 185                 190         
Ser Pro Gly Lys Tyr Met Ser His Leu Ala Ser Cys Gly Met Gly Leu
        195                 200                 205             
Leu Leu Thr Val Asp Pro Gly Ser Gly Thr Val Leu Trp Thr Gln Asp
    210                 215                 220                 
Leu Gly Val Pro Val Met Gly Val Tyr Thr Trp His Gln Asp Gly Leu
225                 230                 235                 240 
Arg Gln Leu Pro His Leu Thr Leu Ala Arg Asp Thr Leu His Phe Leu
                245                 250                 255     
Ala Leu Arg Trp Gly His Ile Arg Leu Pro Ala Ser Gly Pro Arg Asp
            260                 265                 270         
Thr Ala Thr Leu Phe Ser Thr Leu Asp Thr Gln Leu Leu Met Thr Leu
        275                 280                 285             
Tyr Val Gly Lys Asp Glu Thr Gly Phe Tyr Val Ser Lys Ala Leu Val
    290                 295                 300                 
His Thr Gly Val Ala Leu Val Pro Arg Gly Leu Thr Leu Ala Pro Ala
305                 310                 315                 320 
Asp Gly Pro Thr Thr Asp Glu Val Thr Leu Gln Val Ser Gly Glu Arg
                325                 330                 335     
Glu Gly Ser Pro Ser Thr Ala Val Arg Tyr Pro Ser Gly Ser Val Ala
            340                 345                 350         
Leu Pro Ser Gln Trp Leu Leu Ile Gly His His Glu Leu Pro Pro Val
        355                 360                 365             
Leu His Thr Thr Met Leu Arg Val His Pro Thr Leu Gly Ser Gly Thr
    370                 375                 380                 
Ala Glu Thr Arg Pro Pro Glu Asn Thr Gln Ala Pro Ala Phe Phe Leu
385                 390                 395                 400 
Glu Leu Leu Ser Leu Ser Arg Glu Lys Leu Trp Asp Ser Glu Leu His
                405                 410                 415     
Pro Glu Glu Lys Thr Pro Asp Ser Tyr Leu Gly Leu Gly Pro Gln Asp
            420                 425                 430         
Leu Leu Ala Ala Ser Leu Thr Ala Val Leu Leu Gly Gly Trp Ile Leu
        435                 440                 445             
Phe Val Met Arg Gln Gln Pro Gln Val Val Glu Lys Gln Gln Glu Thr
    450                 455                 460                 
Pro Leu Ala Pro Ala Asp Phe Ala His Ile Ser Gln Asp Ala Gln Ser
465                 470                 475                 480 
Leu His Ser Gly Ala Ser Arg Arg Ser Gln Lys Arg Leu Gln Ser Pro
                485                 490                 495     
Ser Lys Gln Ala Gln Pro Leu Asp Asp Pro Glu Ala Glu Gln Leu Thr
            500                 505                 510         
Val Val Gly Lys Ile Ser Phe Asn Pro Lys Asp Val Leu Gly Arg Gly
        515                 520                 525             
Ala Gly Gly Thr Phe Val Phe Arg Gly Gln Phe Glu Gly Arg Ala Val
    530                 535                 540                 
Ala Val Lys Arg Leu Leu Arg Glu Cys Phe Gly Leu Val Arg Arg Glu
545                 550                 555                 560 
Val Gln Leu Leu Gln Glu Ser Asp Arg His Pro Asn Val Leu Arg Tyr
                565                 570                 575     
Phe Cys Thr Glu Arg Gly Pro Gln Phe His Tyr Ile Ala Leu Glu Leu
            580                 585                 590         
Cys Arg Ala Ser Leu Gln Glu Tyr Val Glu Asn Pro Asp Leu Asp Arg
        595                 600                 605             
Gly Gly Leu Glu Pro Glu Val Val Leu Gln Gln Leu Met Ser Gly Leu
    610                 615                 620                 
Ala His Leu His Ser Leu His Ile Val His Arg Asp Leu Lys Pro Gly
625                 630                 635                 640 
Asn Ile Leu Ile Thr Gly Pro Asp Ser Gln Gly Leu Gly Arg Val Val
                645                 650                 655     
Leu Ser Asp Phe Gly Leu Cys Lys Lys Leu Pro Ala Gly Arg Cys Ser
            660                 665                 670         
Phe Ser Leu His Ser Gly Ile Pro Gly Thr Glu Gly Trp Met Ala Pro
        675                 680                 685             
Glu Leu Leu Gln Leu Leu Pro Pro Asp Ser Pro Thr Ser Ala Val Asp
    690                 695                 700                 
Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Leu Ser Gly Gly Ser
705                 710                 715                 720 
His Pro Phe Gly Asp Ser Leu Tyr Arg Gln Ala Asn Ile Leu Thr Gly
                725                 730                 735     
Ala Pro Cys Leu Ala His Leu Glu Glu Glu Val His Asp Lys Val Val
            740                 745                 750         
Ala Arg Asp Leu Val Gly Ala Met Leu Ser Pro Leu Pro Gln Pro Arg
        755                 760                 765             
Pro Ser Ala Pro Gln Val Leu Ala His Pro Phe Phe Trp Ser Arg Ala
    770                 775                 780                 
Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Trp Leu Glu Lys Glu
785                 790                 795                 800 
Ser Glu Gln Glu Pro Leu Val Arg Ala Leu Glu Ala Gly Gly Cys Ala
                805                 810                 815     
Val Val Arg Asp Asn Trp His Glu His Ile Ser Met Pro Leu Gln Ile
            820                 825                 830         


<210> 8907
<211> 818
<212> PRT
<213> Homo sapiens

<400> 8907
Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly
 1               5                  10                  15      
Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg
            20                  25                  30          
Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala
        35                  40                  45              
Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu
    50                  55                  60                  
Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro
65                  70                  75                  80  
Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr
                85                  90                  95      
Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile
            100                 105                 110         
His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp
        115                 120                 125             
Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr
    130                 135                 140                 
Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser
145                 150                 155                 160 
Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg
                165                 170                 175     
Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp
            180                 185                 190         
Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly
        195                 200                 205             
Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val
    210                 215                 220                 
Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr
225                 230                 235                 240 
Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln
                245                 250                 255     
Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu
            260                 265                 270         
Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro
        275                 280                 285             
Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr
    290                 295                 300                 
Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu
305                 310                 315                 320 
Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His
                325                 330                 335     
Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp
            340                 345                 350         
Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp
        355                 360                 365             
Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro
    370                 375                 380                 
Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp
385                 390                 395                 400 
Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr
                405                 410                 415     
Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr
            420                 425                 430         
Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro
        435                 440                 445             
Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Pro Pro Leu
    450                 455                 460                 
Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val
465                 470                 475                 480 
Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser
                485                 490                 495     
Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser
            500                 505                 510         
Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg
        515                 520                 525             
Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe
    530                 535                 540                 
Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro
545                 550                 555                 560 
Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr
                565                 570                 575     
Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser
            580                 585                 590         
Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu
        595                 600                 605             
Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val
    610                 615                 620                 
Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp
625                 630                 635                 640 
His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu
                645                 650                 655     
Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu
            660                 665                 670         
Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu
        675                 680                 685             
Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys
    690                 695                 700                 
Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg
705                 710                 715                 720 
Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys
                725                 730                 735     
Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln
            740                 745                 750         
Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser
        755                 760                 765             
Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala
    770                 775                 780                 
Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn
785                 790                 795                 800 
Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Val Ser Lys Phe Tyr
                805                 810                 815     
Gly Ile
        


<210> 8908
<211> 963
<212> PRT
<213> Homo sapiens

<400> 8908
Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly
 1               5                  10                  15      
Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg
            20                  25                  30          
Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala
        35                  40                  45              
Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu
    50                  55                  60                  
Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro
65                  70                  75                  80  
Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr
                85                  90                  95      
Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile
            100                 105                 110         
His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp
        115                 120                 125             
Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr
    130                 135                 140                 
Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser
145                 150                 155                 160 
Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg
                165                 170                 175     
Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp
            180                 185                 190         
Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly
        195                 200                 205             
Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val
    210                 215                 220                 
Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr
225                 230                 235                 240 
Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln
                245                 250                 255     
Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu
            260                 265                 270         
Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro
        275                 280                 285             
Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr
    290                 295                 300                 
Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu
305                 310                 315                 320 
Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His
                325                 330                 335     
Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp
            340                 345                 350         
Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp
        355                 360                 365             
Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro
    370                 375                 380                 
Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp
385                 390                 395                 400 
Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr
                405                 410                 415     
Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr
            420                 425                 430         
Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro
        435                 440                 445             
Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Pro Pro Leu
    450                 455                 460                 
Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val
465                 470                 475                 480 
Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser
                485                 490                 495     
Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser
            500                 505                 510         
Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg
        515                 520                 525             
Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe
    530                 535                 540                 
Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro
545                 550                 555                 560 
Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr
                565                 570                 575     
Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser
            580                 585                 590         
Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu
        595                 600                 605             
Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val
    610                 615                 620                 
Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp
625                 630                 635                 640 
His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu
                645                 650                 655     
Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu
            660                 665                 670         
Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu
        675                 680                 685             
Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys
    690                 695                 700                 
Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg
705                 710                 715                 720 
Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys
                725                 730                 735     
Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln
            740                 745                 750         
Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser
        755                 760                 765             
Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala
    770                 775                 780                 
Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn
785                 790                 795                 800 
Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn
                805                 810                 815     
Pro Glu Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser
            820                 825                 830         
Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro
        835                 840                 845             
Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala
    850                 855                 860                 
Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp
865                 870                 875                 880 
Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu
                885                 890                 895     
Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile
            900                 905                 910         
Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr
        915                 920                 925             
Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly
    930                 935                 940                 
Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn
945                 950                 955                 960 
Ser Asp Gln
            


<210> 8909
<211> 297
<212> PRT
<213> Homo sapiens

<400> 8909
Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala
 1               5                  10                  15      
Glu Ser Thr Gly Thr Thr Ser His Arg Thr Thr Lys Ser His Lys Thr
            20                  25                  30          
Thr Thr His Arg Thr Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr
        35                  40                  45              
Thr Ala Thr His Asn Pro Thr Thr Thr Ser His Gly Asn Ala Thr Val
    50                  55                  60                  
His Pro Thr Ser Asn Ser Thr Ala Thr Ser Pro Gly Phe Thr Ser Ser
65                  70                  75                  80  
Ala His Pro Glu Pro Pro Pro Pro Ser Pro Ser Pro Ser Pro Thr Ser
                85                  90                  95      
Lys Glu Thr Ile Gly Asp Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys
            100                 105                 110         
Val His Leu Gln Ala Gln Ile Gln Ile Arg Val Met Tyr Thr Thr Gln
        115                 120                 125             
Gly Gly Gly Glu Ala Trp Gly Ile Ser Val Leu Asn Pro Asn Lys Thr
    130                 135                 140                 
Lys Val Gln Gly Ser Cys Glu Gly Ala His Pro His Leu Leu Leu Ser
145                 150                 155                 160 
Phe Pro Tyr Gly His Leu Ser Phe Gly Phe Met Gln Asp Leu Gln Gln
                165                 170                 175     
Lys Val Val Tyr Leu Ser Tyr Met Ala Val Glu Tyr Asn Val Ser Phe
            180                 185                 190         
Pro His Ala Ala Lys Trp Thr Phe Ser Ala Gln Asn Ala Ser Leu Arg
        195                 200                 205             
Asp Leu Gln Ala Pro Leu Gly Gln Ser Phe Ser Cys Ser Asn Ser Ser
    210                 215                 220                 
Ile Ile Leu Ser Pro Ala Val His Leu Asp Leu Leu Ser Leu Arg Leu
225                 230                 235                 240 
Gln Ala Ala Gln Leu Pro His Thr Gly Val Phe Gly Gln Ser Phe Ser
                245                 250                 255     
Cys Pro Ser Asp Arg Ser Ile Leu Leu Pro Leu Ile Ile Gly Leu Ile
            260                 265                 270         
Leu Leu Gly Leu Leu Ala Leu Val Leu Ile Ala Phe Cys Ile Ile Arg
        275                 280                 285             
Arg Arg Pro Ser Ala Tyr Gln Ala Leu
    290                 295         


<210> 8910
<211> 354
<212> PRT
<213> Homo sapiens

<400> 8910
Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala
 1               5                  10                  15      
Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu
            20                  25                  30          
Leu Pro Ser Phe Thr Val Thr Pro Thr Val Thr Glu Ser Thr Gly Thr
        35                  40                  45              
Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr
    50                  55                  60                  
Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr Thr Ala Thr His Asn
65                  70                  75                  80  
Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His Pro Thr Ser Asn
                85                  90                  95      
Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Ser Pro Ala
            100                 105                 110         
Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr
        115                 120                 125             
Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His Pro Glu Pro Pro Pro
    130                 135                 140                 
Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu Thr Ile Gly Asp Tyr
145                 150                 155                 160 
Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile
                165                 170                 175     
Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly
            180                 185                 190         
Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu
        195                 200                 205             
Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser
    210                 215                 220                 
Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val Val Tyr Leu Ser Tyr
225                 230                 235                 240 
Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Lys Trp Thr
                245                 250                 255     
Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly
            260                 265                 270         
Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val
        275                 280                 285             
His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His
    290                 295                 300                 
Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile
305                 310                 315                 320 
Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Leu Ala Leu
                325                 330                 335     
Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg Pro Ser Ala Tyr Gln
            340                 345                 350         
Ala Leu
        


<210> 8911
<211> 413
<212> PRT
<213> Homo sapiens

<400> 8911
Met Glu Asn Met Leu Leu Trp Leu Ile Phe Phe Thr Pro Gly Trp Thr
 1               5                  10                  15      
Leu Ile Asp Gly Ser Glu Met Glu Trp Asp Phe Met Trp His Leu Arg
            20                  25                  30          
Lys Val Pro Arg Ile Val Ser Glu Arg Thr Phe His Leu Thr Ser Pro
        35                  40                  45              
Ala Phe Glu Ala Asp Ala Lys Met Met Val Asn Thr Val Cys Gly Ile
    50                  55                  60                  
Glu Cys Gln Lys Glu Leu Pro Thr Pro Ser Leu Ser Glu Leu Glu Asp
65                  70                  75                  80  
Tyr Leu Ser Tyr Glu Thr Val Phe Glu Asn Gly Thr Arg Thr Leu Thr
                85                  90                  95      
Arg Val Lys Val Gln Asp Leu Val Leu Glu Pro Thr Gln Asn Ile Thr
            100                 105                 110         
Thr Lys Gly Val Ser Val Arg Arg Lys Arg Gln Val Tyr Gly Thr Asp
        115                 120                 125             
Ser Arg Phe Ser Ile Leu Asp Lys Arg Phe Leu Thr Asn Phe Pro Phe
    130                 135                 140                 
Ser Thr Ala Val Lys Leu Ser Thr Gly Cys Ser Gly Ile Leu Ile Ser
145                 150                 155                 160 
Pro Gln His Val Leu Thr Ala Ala His Cys Val His Asp Gly Lys Asp
                165                 170                 175     
Tyr Val Lys Gly Ser Lys Lys Leu Arg Val Gly Leu Leu Lys Met Arg
            180                 185                 190         
Asn Lys Ser Gly Gly Lys Lys Arg Arg Gly Ser Lys Arg Ser Arg Arg
        195                 200                 205             
Glu Ala Ser Gly Gly Asp Gln Arg Glu Gly Thr Arg Glu His Leu Gln
    210                 215                 220                 
Glu Arg Ala Lys Gly Gly Arg Arg Arg Lys Lys Ser Gly Arg Gly Gln
225                 230                 235                 240 
Arg Ile Ala Glu Gly Arg Pro Ser Phe Gln Trp Thr Arg Val Lys Asn
                245                 250                 255     
Thr His Ile Pro Lys Gly Trp Ala Arg Gly Gly Met Gly Asp Ala Thr
            260                 265                 270         
Leu Asp Tyr Asp Tyr Ala Leu Leu Glu Leu Lys Arg Ala His Lys Lys
        275                 280                 285             
Lys Tyr Met Glu Leu Gly Ile Ser Pro Thr Ile Lys Lys Met Pro Gly
    290                 295                 300                 
Gly Met Ile His Phe Ser Gly Phe Asp Asn Asp Arg Ala Asp Gln Leu
305                 310                 315                 320 
Val Tyr Arg Phe Cys Ser Val Ser Asp Glu Ser Asn Asp Leu Leu Tyr
                325                 330                 335     
Gln Tyr Cys Asp Ala Glu Ser Gly Ser Thr Gly Ser Gly Val Tyr Leu
            340                 345                 350         
Arg Leu Lys Asp Pro Asp Lys Lys Asn Trp Lys Arg Lys Ile Ile Ala
        355                 360                 365             
Val Tyr Ser Gly His Gln Trp Val Asp Val His Gly Val Gln Lys Asp
    370                 375                 380                 
Tyr Asn Val Ala Val Arg Ile Thr Pro Leu Lys Tyr Ala Gln Ile Cys
385                 390                 395                 400 
Leu Trp Ile His Gly Asn Asp Ala Asn Cys Ala Tyr Gly
                405                 410             


<210> 8912
<211> 377
<212> PRT
<213> Homo sapiens

<400> 8912
Met Ala Asp Phe Leu Pro Ser Arg Ser Val Leu Ser Val Cys Phe Pro
 1               5                  10                  15      
Gly Cys Leu Leu Thr Ser Gly Glu Ala Glu Gln Gln Arg Lys Ser Lys
            20                  25                  30          
Glu Ile Asp Lys Cys Leu Ser Arg Glu Lys Thr Tyr Val Lys Arg Leu
        35                  40                  45              
Val Lys Ile Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Phe
    50                  55                  60                  
Leu Lys Gln Met Arg Ile Ile His Gly Gln Asp Phe Asp Gln Arg Ala
65                  70                  75                  80  
Arg Glu Glu Phe Arg Pro Thr Ile Tyr Ser Asn Val Ile Lys Gly Met
                85                  90                  95      
Arg Val Leu Val Asp Ala Arg Glu Lys Leu His Ile Pro Trp Gly Asp
            100                 105                 110         
Asn Ser Asn Gln Gln His Gly Asp Lys Met Met Ser Phe Asp Thr Arg
        115                 120                 125             
Ala Pro Met Ala Ala Gln Gly Met Val Glu Thr Arg Val Phe Leu Gln
    130                 135                 140                 
Tyr Leu Pro Ala Ile Arg Ala Leu Trp Ala Asp Ser Gly Ile Gln Asn
145                 150                 155                 160 
Ala Tyr Asp Arg Arg Arg Glu Phe Gln Leu Gly Glu Ser Val Lys Tyr
                165                 170                 175     
Phe Leu Asp Asn Leu Asp Lys Leu Gly Glu Pro Asp Tyr Ile Pro Ser
            180                 185                 190         
Gln Gln Asp Ile Leu Leu Ala Arg Arg Pro Thr Lys Gly Ile His Glu
        195                 200                 205             
Tyr Asp Phe Glu Ile Lys Asn Val Pro Phe Lys Met Val Asp Val Gly
    210                 215                 220                 
Gly Gln Arg Ser Glu Arg Lys Arg Trp Phe Glu Cys Phe Asp Ser Val
225                 230                 235                 240 
Thr Ser Ile Leu Phe Leu Val Ser Ser Ser Glu Phe Asp Gln Val Leu
                245                 250                 255     
Met Glu Asp Arg Leu Thr Asn Arg Leu Thr Glu Ser Leu Asn Ile Phe
            260                 265                 270         
Glu Thr Ile Val Asn Asn Arg Val Phe Ser Asn Val Ser Ile Ile Leu
        275                 280                 285             
Phe Leu Asn Lys Thr Asp Leu Leu Glu Glu Lys Val Gln Ile Val Ser
    290                 295                 300                 
Ile Lys Asp Tyr Phe Leu Glu Phe Glu Gly Asp Pro His Cys Leu Arg
305                 310                 315                 320 
Asp Val Gln Lys Phe Leu Val Glu Cys Phe Arg Asn Lys Arg Arg Asp
                325                 330                 335     
Gln Gln Gln Lys Pro Leu Tyr His His Phe Thr Thr Ala Ile Asn Thr
            340                 345                 350         
Glu Asn Ile Arg Leu Val Phe Arg Asp Val Lys Asp Thr Ile Leu His
        355                 360                 365             
Asp Asn Leu Lys Gln Leu Met Leu Gln
    370                 375         


<210> 8913
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 8913
Arg Arg Arg Arg Pro Ser Ser Ser Arg Arg Leu Arg Gly Arg Gly Ala
 1               5                  10                  15      
Ala Gln Met Ala Cys Pro Ala Leu Gly Leu Glu Ala Leu Gln Pro Leu
            20                  25                  30          
Gln Pro Glu Pro Pro Pro Glu Pro Ala Phe Ser Glu Ala Gln Lys Trp
        35                  40                  45              
Ile Glu Gln Val Thr Gly Arg Ser Phe Gly Asp Lys Asp Phe Arg Thr
    50                  55                  60                  
Gly Leu Glu Asn Gly Ile Leu Leu Cys Glu Leu Leu Asn Ala Ile Lys
65                  70                  75                  80  
Pro Gly Leu Val Lys Lys Ile Asn Arg Leu Pro Thr Pro Ile Ala Gly
                85                  90                  95      
Leu Asp Asn Ile Ile Leu Phe Leu Arg Gly Cys Lys Glu Leu Gly Leu
            100                 105                 110         
Lys Glu Ser Gln Leu Phe Asp Pro Ser Asp Leu Gln Asp Thr Ser Asn
        115                 120                 125             
Arg Val Thr Val Lys Ser Leu Asp Tyr Ser Arg Lys Leu Lys Asn Val
    130                 135                 140                 
Leu Val Thr Ile Tyr Trp Leu Gly Lys Ala Ala Asn Ser Cys Thr Ser
145                 150                 155                 160 
Tyr Ser Gly Thr Thr Leu Asn Leu Lys Glu Phe Glu Gly Leu Leu Ala
                165                 170                 175     
Gln Met Arg Lys Asp Thr Asp Asp Ile Glu Ser Pro Lys Arg Ser Ile
            180                 185                 190         
Arg Asp Ser Gly Tyr Ile Asp Cys Trp Asp Ser Glu Arg Ser Asp Ser
        195                 200                 205             
Leu Ser Pro Pro Arg His Gly Arg Asp Asp Ser Phe Asp Ser Leu Asp
    210                 215                 220                 
Ser Phe Gly Ser Arg Ser Arg Gln Thr Pro Ser Pro Asp Val Val Leu
225                 230                 235                 240 
Arg Gly Ser Ser Asp Gly Arg Gly Ser Asp Ser Glu Ser Asp Leu Pro
                245                 250                 255     
His Arg Lys Leu Pro Asp Val Lys Lys Asp Asp Met Ser Ala Arg Arg
            260                 265                 270         
Thr Ser His Gly Glu Pro Lys Ser Ala Val Pro Phe Asn Gln Tyr Leu
        275                 280                 285             
Pro Asn Lys Ser Asn Gln Thr Ala Tyr Val Pro Ala Pro Leu Arg Lys
    290                 295                 300                 
Lys Lys Ala Glu Arg Glu Glu Tyr Arg Lys Ser Trp Ser Thr Ala Thr
305                 310                 315                 320 
Ser Pro Leu Gly Gly Glu Arg Pro Phe Arg Tyr Gly Pro Arg Thr Pro
                325                 330                 335     
Val Ser Asp Asp Ala Glu Ser Thr Ser Met Phe Asp Met Arg Cys Glu
            340                 345                 350         
Glu Glu Ala Ala Val Gln Pro His Ser Arg Ala Arg Gln Glu Gln Leu
        355                 360                 365             
Gln Leu Ile Asn Asn Gln Leu Arg Glu Glu Asp Asp Lys Trp Gln Asp
    370                 375                 380                 
Asp Leu Ala Arg Trp Lys Ser Arg Arg Arg Ser Val Ser Gln Asp Leu
385                 390                 395                 400 
Ile Lys Lys Glu Glu Glu Arg Lys Lys Met Glu Lys Leu Leu Ala Gly
                405                 410                 415     
Glu Asp Gly Thr Ser Glu Arg Arg Lys Ser Ile Lys Thr Tyr Arg Glu
            420                 425                 430         
Ile Val Gln Glu Lys Glu Arg Arg Glu Arg Glu Leu His Glu Ala Tyr
        435                 440                 445             
Lys Asn Ala Arg Ser Gln Glu Glu Ala Glu Gly Ile Leu Gln Gln Tyr
    450                 455                 460                 
Ile Glu Arg Phe Thr Ile Ser Glu Ala Val Leu Glu Arg Leu Glu Met
465                 470                 475                 480 
Pro Lys Ile Leu Glu Arg Ser His Ser Thr Glu Pro Asn Leu Ser Ser
                485                 490                 495     
Phe Leu Asn Asp Pro Asn Pro Met Lys Tyr Leu Arg Gln Gln Ser Leu
            500                 505                 510         
Pro Pro Pro Lys Phe Thr Ala Thr Val Glu Thr Thr Ile Ala Arg Ala
        515                 520                 525             
Ser Val Leu Asp Thr Ser Met Ser Ala Gly Ser Gly Ser Pro Ser Lys
    530                 535                 540                 
Thr Val Thr Pro Lys Ala Val Pro Met Leu Thr Pro Lys Pro Tyr Ser
545                 550                 555                 560 
Gln Pro Lys Asn Ser Gln Asp Val Leu Lys Thr Phe Lys Val Asp Gly
                565                 570                 575     
Lys Val Ser Val Asn Gly Glu Thr Val His Arg Glu Glu Glu Lys Glu
            580                 585                 590         
Arg Glu Cys Pro Thr Val Ala Pro Ala His Ser Leu Thr Lys Ser Gln
        595                 600                 605             
Met Phe Glu Gly Val Ala Arg Val His Gly Ser Pro Leu Glu Leu Lys
    610                 615                 620                 
Gln Asp Asn Gly Ser Ile Glu Ile Asn Ile Lys Lys Pro Asn Ser Val
625                 630                 635                 640 
Pro Gln Glu Leu Ala Ala Thr Thr Glu Lys Thr Glu Pro Asn Ser Gln
                645                 650                 655     
Glu Asp Lys Asn Asp Gly Gly Lys Ser Arg Lys Gly Asn Ile Glu Leu
            660                 665                 670         
Ala Ser Ser Glu Pro Gln His Phe Thr Thr Thr Val Thr Arg Cys Ser
        675                 680                 685             
Pro Thr Val Ala Phe Val Glu Phe Pro Ser Ser Pro Gln Leu Lys Asn
    690                 695                 700                 
Asp Val Ser Glu Glu Lys Asp Gln Lys Lys Pro Glu Asn Glu Met Ser
705                 710                 715                 720 
Gly Lys Val Glu Leu Val Leu Ser Gln Lys Val Val Lys Pro Lys Ser
                725                 730                 735     
Pro Glu Pro Glu Ala Thr Leu Thr Phe Pro Phe Leu Asp Lys Met Pro
            740                 745                 750         
Glu Ala Asn Gln Leu His Leu Pro Asn Leu Asn Ser Gln Val Asp Ser
        755                 760                 765             
Pro Ser Ser Glu Lys Ser Pro Val Thr Thr Pro Gln Phe Lys Phe Trp
    770                 775                 780                 
Ala Trp Asp Pro Glu Glu Glu Arg Arg Arg Gln Glu Lys Trp Gln Gln
785                 790                 795                 800 
Glu Gln Glu Arg Leu Leu Gln Glu Arg Tyr Gln Lys Glu Gln Asp Lys
                805                 810                 815     
Leu Lys Glu Glu Trp Glu Lys Ala Gln Lys Glu Val Glu Glu Glu Glu
            820                 825                 830         
Arg Arg Tyr Tyr Glu Glu Glu Arg Lys Ile Ile Glu Asp Thr Val Val
        835                 840                 845             
Pro Phe Thr Val Ser Ser Ser Ser Ala Asp Gln Leu Ser Thr Ser Ser
    850                 855                 860                 
Ser Met Thr Glu Gly Ser Gly Thr Met Asn Lys Ile Asp Leu Gly Asn
865                 870                 875                 880 
Cys Gln Asp Glu Lys Gln Asp Arg Arg Trp Lys Lys Ser Phe Gln Gly
                885                 890                 895     
Asp Asp Ser Asp Leu Leu Leu Lys Thr Arg Glu Ser Asp Arg Leu Glu
            900                 905                 910         
Glu Lys Gly Ser Leu Thr Glu Gly Ala Leu Ala His Ser Gly Asn Pro
        915                 920                 925             
Val Ser Lys Gly Val His Glu Asp His Gln Leu Asp Thr Glu Ala Gly
    930                 935                 940                 
Ala Pro His Cys Gly Thr Asn Pro Gln Leu Ala Gln Asp Pro Ser Gln
945                 950                 955                 960 
Asn Gln Gln Thr Ser Asn Pro Thr His Ser Ser Glu Asp Val Lys Pro
                965                 970                 975     
Lys Thr Leu Pro Leu Asp Lys Ser Ile Asn His Gln Ile Glu Ser Pro
            980                 985                 990         
Ser Glu Arg Arg Lys Lys Ser Pro Arg Glu His Phe Gln Ala Gly Pro
        995                 1000                1005            
Phe Ser Pro Cys Ser Pro Thr Pro Pro Gly Gln Ser Pro Asn Arg Ser
    1010                1015                1020                
Ile Ser Gly Lys Lys Leu Cys Ser Ser Cys Gly Leu Pro Leu Gly Lys
1025                1030                1035                1040
Gly Ala Ala Met Ile Ile Glu Thr Leu Asn Leu Tyr Phe His Ile Gln
                1045                1050                1055    
Cys Phe Arg Cys Gly Ile Cys Lys Gly Gln Leu Gly Asp Ala Val Ser
            1060                1065                1070        
Gly Thr Asp Val Arg Ile Arg Asn Gly Leu Leu Asn Cys Asn Asp Cys
        1075                1080                1085            
Tyr Met Arg Ser Arg Ser Ala Gly Gln Pro Thr Thr Leu
    1090                1095                1100    


<210> 8914
<211> 1449
<212> PRT
<213> Homo sapiens

<400> 8914
Gly Arg Ser Arg Ser Arg Thr Ser Gly Arg Val Gly Leu Ala Ala Arg
 1               5                  10                  15      
Gly Gly Gly Gly Ala Ala Thr Ala Val Ala Ala Ala Ala Lys Met Ala
            20                  25                  30          
Glu Gly Leu Glu Arg Val Arg Ile Ser Ala Ser Glu Leu Arg Gly Ile
        35                  40                  45              
Leu Ala Thr Leu Ala Pro Gln Ala Gly Ser Arg Glu Asn Met Lys Glu
    50                  55                  60                  
Leu Lys Glu Ala Arg Pro Arg Lys Asp Asn Arg Arg Pro Asp Leu Glu
65                  70                  75                  80  
Ile Tyr Lys Pro Gly Leu Ser Arg Leu Arg Asn Lys Pro Lys Ile Lys
                85                  90                  95      
Glu Pro Pro Gly Ser Glu Glu Phe Lys Asp Glu Ile Val Asn Asp Arg
            100                 105                 110         
Asp Cys Ser Ala Val Glu Asn Gly Thr Gln Pro Val Lys Asp Val Cys
        115                 120                 125             
Lys Glu Leu Asn Asn Gln Glu Gln Asn Gly Pro Ile Asp Pro Glu Asn
    130                 135                 140                 
Asn Arg Gly Gln Glu Ser Phe Pro Arg Thr Ala Gly Gln Glu Asp Arg
145                 150                 155                 160 
Ser Leu Lys Ile Ile Lys Arg Thr Lys Lys Pro Asp Leu Gln Ile Tyr
                165                 170                 175     
Gln Pro Gly Arg Arg Leu Gln Thr Val Ser Lys Glu Ser Ala Ser Arg
            180                 185                 190         
Val Glu Glu Glu Glu Val Leu Asn Gln Val Glu Gln Leu Arg Val Glu
        195                 200                 205             
Glu Asp Glu Cys Arg Gly Asn Val Ala Lys Glu Glu Val Ala Asn Lys
    210                 215                 220                 
Pro Asp Arg Ala Glu Ile Glu Lys Ser Pro Gly Gly Gly Arg Val Gly
225                 230                 235                 240 
Ala Ala Lys Gly Glu Lys Gly Lys Arg Met Gly Lys Gly Glu Gly Val
                245                 250                 255     
Arg Glu Thr His Asp Asp Pro Ala Arg Gly Arg Pro Gly Ser Ala Lys
            260                 265                 270         
Arg Tyr Ser Arg Ser Asp Lys Arg Arg Asn Arg Tyr Arg Thr Arg Ser
        275                 280                 285             
Thr Ser Ser Ala Gly Ser Asn Asn Ser Ala Glu Gly Ala Gly Leu Thr
    290                 295                 300                 
Asp Asn Gly Cys Arg Arg Arg Arg Gln Asp Arg Thr Lys Glu Arg Pro
305                 310                 315                 320 
Pro Leu Lys Lys Gln Val Ser Val Ser Ser Thr Asp Ser Leu Asp Glu
                325                 330                 335     
Asp Arg Ile Asp Glu Pro Asp Gly Leu Gly Pro Arg Arg Ser Ser Glu
            340                 345                 350         
Arg Lys Arg His Leu Glu Arg Asn Trp Ser Gly Arg Gly Glu Gly Glu
        355                 360                 365             
Gln Lys Thr Ser Ala Lys Glu Tyr Arg Gly Thr Leu Arg Val Thr Phe
    370                 375                 380                 
Asp Ala Glu Ala Met Asn Lys Glu Ser Pro Met Val Arg Ser Ala Arg
385                 390                 395                 400 
Asp Asp Met Asp Arg Gly Lys Pro Asp Lys Gly Leu Ser Ser Gly Gly
                405                 410                 415     
Lys Gly Ser Glu Lys Gln Glu Ser Lys Asn Pro Lys Gln Glu Leu Arg
            420                 425                 430         
Gly Arg Gly Arg Gly Ile Leu Ile Leu Pro Ala His Thr Thr Leu Ser
        435                 440                 445             
Val Asn Ser Ala Gly Ser Pro Glu Ser Ala Pro Leu Gly Pro Arg Leu
    450                 455                 460                 
Leu Phe Gly Ser Gly Ser Lys Gly Ser Arg Ser Trp Gly Arg Gly Gly
465                 470                 475                 480 
Thr Thr Arg Arg Leu Trp Asp Pro Asn Asn Pro Asp Gln Lys Pro Ala
                485                 490                 495     
Leu Lys Thr Gln Thr Pro Gln Leu His Phe Leu Asp Thr Asp Asp Glu
            500                 505                 510         
Val Ser Pro Thr Ser Trp Gly Asp Ser Arg Gln Ala Gln Ala Ser Tyr
        515                 520                 525             
Tyr Lys Phe Gln Asn Ser Asp Asn Pro Tyr Tyr Tyr Pro Arg Thr Pro
    530                 535                 540                 
Gly Pro Ala Ser Gln Tyr Pro Tyr Thr Gly Tyr Asn Pro Leu Gln Tyr
545                 550                 555                 560 
Pro Val Gly Pro Thr Asn Gly Val Tyr Pro Gly Pro Tyr Tyr Pro Gly
                565                 570                 575     
Tyr Pro Thr Pro Ser Gly Gln Tyr Val Cys Ser Pro Leu Pro Thr Ser
            580                 585                 590         
Thr Met Ser Pro Glu Glu Val Glu Gln His Met Arg Asn Leu Gln Gln
        595                 600                 605             
Gln Glu Leu His Arg Leu Leu Arg Val Ala Asp Asn Gln Glu Leu Gln
    610                 615                 620                 
Leu Ser Asn Leu Leu Ser Arg Asp Arg Ile Ser Pro Glu Gly Leu Glu
625                 630                 635                 640 
Lys Met Ala Gln Leu Arg Ala Glu Leu Leu Gln Leu Tyr Glu Arg Cys
                645                 650                 655     
Ile Leu Leu Asp Ile Glu Phe Ser Asp Asn Gln Asn Val Asp Gln Ile
            660                 665                 670         
Leu Trp Lys Asn Ala Phe Tyr Gln Val Ile Glu Lys Phe Arg Gln Leu
        675                 680                 685             
Val Lys Asp Pro Asn Val Glu Asn Pro Glu Gln Ile Arg Asn Arg Leu
    690                 695                 700                 
Leu Glu Leu Leu Asp Glu Gly Ser Asp Phe Phe Asp Ser Leu Leu Gln
705                 710                 715                 720 
Lys Leu Gln Val Thr Tyr Lys Phe Lys Leu Glu Asp Tyr Met Asp Gly
                725                 730                 735     
Leu Ala Ile Arg Ser Lys Pro Leu Arg Lys Thr Val Lys Tyr Ala Leu
            740                 745                 750         
Ile Ser Ala Gln Arg Cys Met Ile Cys Gln Gly Asp Ile Ala Arg Tyr
        755                 760                 765             
Arg Glu Gln Ala Ser Asp Thr Ala Asn Tyr Gly Lys Ala Arg Ser Trp
    770                 775                 780                 
Tyr Leu Lys Ala Gln His Ile Ala Pro Lys Asn Gly Arg Pro Tyr Asn
785                 790                 795                 800 
Gln Leu Ala Leu Leu Ala Val Tyr Thr Arg Arg Lys Leu Asp Ala Val
                805                 810                 815     
Tyr Tyr Tyr Met Arg Ser Leu Ala Ala Ser Asn Pro Ile Leu Thr Ala
            820                 825                 830         
Lys Glu Ser Leu Met Ser Leu Phe Glu Glu Thr Lys Arg Lys Ala Glu
        835                 840                 845             
Gln Met Glu Lys Lys Gln His Glu Glu Phe Asp Leu Ser Pro Asp Gln
    850                 855                 860                 
Trp Arg Lys Gly Lys Lys Ser Thr Phe Arg His Val Gly Asp Asp Thr
865                 870                 875                 880 
Thr Arg Leu Glu Ile Trp Ile His Pro Ser His Pro Arg Ser Ser Gln
                885                 890                 895     
Gly Thr Glu Ser Gly Lys Asp Ser Glu Gln Glu Asn Gly Leu Gly Ser
            900                 905                 910         
Leu Ser Pro Ser Asp Leu Asn Lys Arg Phe Ile Leu Ser Phe Leu His
        915                 920                 925             
Ala His Gly Lys Leu Phe Thr Arg Ile Gly Met Glu Thr Phe Pro Ala
    930                 935                 940                 
Val Ala Glu Lys Val Leu Lys Glu Phe Gln Val Leu Leu Gln His Ser
945                 950                 955                 960 
Pro Ser Pro Ile Gly Ser Thr Arg Met Leu Gln Leu Met Thr Ile Asn
                965                 970                 975     
Met Phe Ala Val His Asn Ser Gln Leu Lys Asp Cys Phe Ser Glu Glu
            980                 985                 990         
Cys Arg Ser Val Ile Gln Glu Gln Ala Ala Ala Leu Gly Leu Ala Met
        995                 1000                1005            
Phe Ser Leu Leu Val Arg Arg Cys Thr Cys Leu Leu Lys Glu Ser Ala
    1010                1015                1020                
Lys Ala Gln Leu Ser Ser Pro Glu Asp Gln Asp Asp Gln Asp Asp Ile
1025                1030                1035                1040
Lys Val Ser Ser Phe Val Pro Asp Leu Lys Glu Leu Leu Pro Ser Val
                1045                1050                1055    
Lys Val Trp Ser Asp Trp Met Leu Gly Tyr Pro Asp Thr Trp Asn Pro
            1060                1065                1070        
Pro Pro Thr Ser Leu Asp Leu Pro Ser His Val Ala Val Asp Val Trp
        1075                1080                1085            
Ser Thr Leu Ala Asp Phe Cys Asn Ile Leu Thr Ala Val Asn Gln Ser
    1090                1095                1100                
Glu Val Pro Leu Tyr Lys Asp Pro Asp Asp Asp Leu Thr Leu Leu Ile
1105                1110                1115                1120
Leu Glu Glu Asp Arg Leu Leu Ser Gly Phe Val Pro Leu Leu Ala Ala
                1125                1130                1135    
Pro Gln Asp Pro Cys Tyr Val Glu Lys Thr Ser Asp Lys Val Ile Ala
            1140                1145                1150        
Ala Asp Cys Lys Arg Val Thr Val Leu Lys Tyr Phe Leu Glu Ala Leu
        1155                1160                1165            
Cys Gly Gln Glu Glu Pro Leu Leu Ala Phe Lys Gly Gly Lys Tyr Val
    1170                1175                1180                
Ser Val Ala Pro Val Pro Asp Thr Met Gly Lys Glu Met Gly Ser Gln
1185                1190                1195                1200
Glu Gly Thr Arg Leu Glu Asp Glu Glu Glu Asp Val Val Ile Glu Asp
                1205                1210                1215    
Phe Glu Glu Asp Ser Glu Ala Glu Gly Ser Gly Gly Glu Asp Asp Ile
            1220                1225                1230        
Arg Glu Leu Arg Ala Lys Lys Leu Ala Leu Ala Arg Lys Ile Ala Glu
        1235                1240                1245            
Gln Gln Arg Arg Gln Glu Lys Ile Gln Ala Val Leu Glu Asp His Ser
    1250                1255                1260                
Gln Met Arg Gln Met Glu Leu Glu Ile Arg Pro Leu Phe Leu Val Pro
1265                1270                1275                1280
Asp Thr Asn Gly Phe Ile Asp His Leu Ala Ser Leu Ala Arg Leu Leu
                1285                1290                1295    
Glu Ser Arg Lys Tyr Ile Leu Val Val Pro Leu Ile Val Ile Asn Glu
            1300                1305                1310        
Leu Asp Gly Leu Ala Lys Gly Gln Glu Thr Asp His Arg Ala Gly Gly
        1315                1320                1325            
Tyr Ala Arg Val Val Gln Glu Lys Ala Arg Lys Ser Ile Glu Phe Leu
    1330                1335                1340                
Glu Gln Arg Phe Glu Ser Arg Asp Ser Cys Leu Arg Ala Leu Thr Ser
1345                1350                1355                1360
Arg Gly Asn Glu Leu Glu Ser Ile Ala Phe Arg Ser Glu Asp Ile Thr
                1365                1370                1375    
Gly Gln Leu Gly Asn Asn Asp Asp Leu Ile Leu Ser Cys Cys Leu His
            1380                1385                1390        
Tyr Cys Lys Asp Lys Ala Lys Asp Phe Met Pro Ala Ser Lys Glu Glu
        1395                1400                1405            
Pro Ile Arg Leu Leu Arg Glu Val Val Leu Leu Thr Asp Asp Arg Asn
    1410                1415                1420                
Leu Arg Val Lys Ala Leu Thr Arg Asn Val Pro Val Arg Asp Ile Pro
1425                1430                1435                1440
Ala Phe Leu Thr Trp Ala Gln Val Gly
                1445                


<210> 8915
<211> 411
<212> PRT
<213> Homo sapiens

<400> 8915
Met Lys Glu Leu Lys Glu Ala Arg Pro Arg Lys Asp Asn Arg Arg Pro
 1               5                  10                  15      
Asp Leu Glu Ile Tyr Lys Pro Gly Leu Ser Arg Leu Arg Asn Lys Pro
            20                  25                  30          
Lys Ile Lys Glu Pro Pro Gly Ser Glu Glu Phe Lys Asp Glu Ile Val
        35                  40                  45              
Asn Asp Arg Asp Cys Ser Ala Val Glu Asn Gly Thr Gln Pro Val Lys
    50                  55                  60                  
Asp Val Cys Lys Glu Leu Asn Asn Gln Glu Gln Asn Gly Pro Ile Asp
65                  70                  75                  80  
Pro Glu Asn Asn Arg Gly Gln Glu Ser Phe Pro Arg Thr Ala Gly Gln
                85                  90                  95      
Glu Asp Arg Ser Leu Lys Ile Ile Lys Arg Thr Lys Lys Pro Asp Leu
            100                 105                 110         
Gln Ile Tyr Gln Pro Gly Arg Arg Leu Gln Thr Val Ser Lys Glu Ser
        115                 120                 125             
Ala Ser Arg Val Glu Glu Glu Glu Val Leu Asn Gln Val Glu Gln Leu
    130                 135                 140                 
Arg Val Glu Glu Asp Glu Cys Arg Gly Asn Val Ala Lys Glu Glu Val
145                 150                 155                 160 
Ala Asn Lys Pro Asp Arg Ala Glu Ile Glu Lys Ser Pro Gly Gly Gly
                165                 170                 175     
Arg Val Gly Ala Ala Lys Gly Glu Lys Gly Lys Arg Met Gly Lys Gly
            180                 185                 190         
Glu Gly Val Arg Glu Thr His Asp Asp Pro Ala Arg Gly Arg Pro Gly
        195                 200                 205             
Ser Ala Lys Arg Tyr Ser Arg Ser Asp Lys Arg Arg Asn Arg Tyr Arg
    210                 215                 220                 
Thr Arg Ser Thr Ser Ser Ala Gly Ser Asn Asn Ser Ala Glu Gly Ala
225                 230                 235                 240 
Gly Leu Thr Asp Asn Gly Cys Arg Arg Arg Arg Gln Asp Arg Thr Lys
                245                 250                 255     
Glu Arg Pro Arg Leu Lys Gln Gln Val Ser Val Ser Ser Thr Asp Ser
            260                 265                 270         
Leu Asp Glu Asp Arg Ile Asp Glu Pro Asp Gly Leu Gly Pro Arg Arg
        275                 280                 285             
Ser Ser Glu Arg Lys Arg His Leu Glu Arg Asn Trp Ser Gly Arg Gly
    290                 295                 300                 
Glu Gly Glu Gln Lys Asn Ser Ala Lys Glu Tyr Arg Gly Thr Leu Arg
305                 310                 315                 320 
Val Thr Phe Asp Ala Glu Ala Met Asn Lys Glu Ser Pro Met Val Arg
                325                 330                 335     
Ser Ala Arg Asp Asp Met Asp Arg Gly Lys Pro Asp Lys Gly Leu Ser
            340                 345                 350         
Ser Gly Gly Lys Gly Ser Glu Lys Gln Glu Ser Lys Asn Pro Lys Gln
        355                 360                 365             
Glu Leu Arg Gly Arg Gly Arg Gly Ile Leu Ile Leu Pro Ala His Thr
    370                 375                 380                 
Thr Leu Ser Val Asn Ser Ala Gly Ser Pro Glu Ser Ala Pro Leu Gly
385                 390                 395                 400 
Pro Arg Pro Pro Lys Val Leu Gly Leu Gln Val
                405                 410     


<210> 8916
<211> 184
<212> PRT
<213> Homo sapiens

<400> 8916
Met Ala Pro Leu Leu Pro Ile Arg Thr Leu Pro Leu Ile Leu Ile Leu
 1               5                  10                  15      
Leu Ala Leu Leu Ser Pro Gly Ala Ala Asp Phe Asn Ile Ser Ser Leu
            20                  25                  30          
Ser Gly Leu Leu Ser Pro Ala Leu Thr Glu Ser Leu Leu Val Ala Leu
        35                  40                  45              
Pro Pro Cys His Leu Thr Gly Gly Asn Ala Thr Leu Met Val Arg Arg
    50                  55                  60                  
Ala Asn Asp Ser Lys Val Val Thr Ser Ser Phe Val Val Pro Pro Cys
65                  70                  75                  80  
Arg Gly Arg Arg Glu Leu Val Ser Val Val Asp Ser Gly Ala Gly Phe
                85                  90                  95      
Thr Val Thr Arg Leu Ser Ala Tyr Gln Val Thr Asn Leu Val Pro Gly
            100                 105                 110         
Thr Lys Phe Tyr Ile Ser Tyr Leu Val Lys Lys Gly Thr Ala Thr Glu
        115                 120                 125             
Ser Ser Arg Glu Ile Pro Met Ser Thr Leu Pro Arg Arg Asn Met Glu
    130                 135                 140                 
Ser Ile Gly Leu Gly Met Ala Arg Thr Gly Gly Met Val Val Ile Thr
145                 150                 155                 160 
Val Leu Leu Ser Val Ala Met Phe Leu Leu Val Leu Gly Phe Ile Ile
                165                 170                 175     
Ala Leu Ala Leu Gly Ser Arg Lys
            180                 


<210> 8917
<211> 423
<212> PRT
<213> Homo sapiens

<400> 8917
Met Ala Glu Leu Leu Leu Met Leu Leu Leu Pro Gly Pro Ser Gly Arg
 1               5                  10                  15      
Ala Ala Thr Asn Ser Thr Pro Arg Arg Arg Arg Arg Arg Val Phe Pro
            20                  25                  30          
Ala Lys Asp Lys Pro Pro Leu Glu Gln Pro His Pro Pro Gly His Arg
        35                  40                  45              
Glu Cys Trp Val Pro Leu Thr Pro Pro Gly Ser Asp Arg Leu Pro Ser
    50                  55                  60                  
Thr Leu Leu Ala Ser Pro Gly Ser Ile His Thr Gly Gln Val Leu Gly
65                  70                  75                  80  
Lys Tyr Ala Met Ser Asn Glu Cys Leu Leu Ser Lys Gly Ala Trp His
                85                  90                  95      
Ser Phe Tyr Lys Gln Asn Gly Pro Ser Ala Val Arg Ala Ser Thr Trp
            100                 105                 110         
Leu Ala Leu Asn Gln Ser Leu His Thr Val Gly Ala Gln Ser Ile Pro
        115                 120                 125             
Ala His Ser Arg Arg Ser Ile Asn Pro Cys Thr Gln Ser Gly His Asn
    130                 135                 140                 
Gln Ser Leu His Thr Val Gly Ala Gln Ser Ile Thr Ala His Ser Arg
145                 150                 155                 160 
His Ser Thr Asn His Ser Thr Gln Ser Ser Leu Asn Gln Ser Gln His
                165                 170                 175     
Thr Val Gly Thr Gln Pro Ile Pro Ala His Ser Arg Arg Ser Thr Asn
            180                 185                 190         
His Ser Thr Gln Ser Ala Leu Asn Gln Ser Leu His Thr Val Gly Ala
        195                 200                 205             
Gln Pro Ile Pro Ala His Ser Arg Arg Ser Thr Asn His Cys Thr Gln
    210                 215                 220                 
Ser Ala Leu Asn Gln Ser Gln His Thr Val Gly Ala Gln Pro Ile Thr
225                 230                 235                 240 
Ala His Ser Arg Arg Ser Thr Asn Pro Cys Thr Gln Ser Ala Leu Asn
                245                 250                 255     
Gln Ser Gln His Thr Val Gly Ala Gln Pro Ile Thr Ala His Ser Arg
            260                 265                 270         
Arg Ser Thr Asn His Ser Thr Gln Ser Ala Leu Asn Gln Ser Leu His
        275                 280                 285             
Thr Val Gly Ala Gln Pro Ile Thr Ala His Ser Arg Arg Ser Ile Asn
    290                 295                 300                 
Pro Cys Thr Gln Ser Ala Leu Asn Gln Ser Leu His Thr Ser Ala Leu
305                 310                 315                 320 
Asn Gln Ser Leu His Thr Val Gly Ala Gln Pro Ile Pro Ala His Ser
                325                 330                 335     
Arg Arg Ser Thr Asn His Cys Thr Gln Ser Ala Leu Asn Gln Ser Gln
            340                 345                 350         
His Thr Val Gly Ala Gln Pro Ile Pro Ala His Ser Arg Arg Arg Ser
        355                 360                 365             
Thr Asn His Ser Thr Gln Ser Ala Leu Asn Gln Ser Gln His Thr Val
    370                 375                 380                 
Gly Ala Gln Pro Ile Pro Ala His Ser Arg Arg Ser Thr Asn His Cys
385                 390                 395                 400 
Thr Gln Ser Ala Leu Asn Gln Ser Leu His Thr Val Ser Ala Gln Gln
                405                 410                 415     
Ile Thr Ala His Ser Arg Arg
            420             


<210> 8918
<211> 569
<212> PRT
<213> Homo sapiens

<400> 8918
Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser
 1               5                  10                  15      
Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu
            20                  25                  30          
Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro
        35                  40                  45              
Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr
    50                  55                  60                  
Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys
65                  70                  75                  80  
Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys
                85                  90                  95      
Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys
            100                 105                 110         
Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe
        115                 120                 125             
Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr
    130                 135                 140                 
Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp
145                 150                 155                 160 
Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly
                165                 170                 175     
Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly
            180                 185                 190         
Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro
        195                 200                 205             
Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr
    210                 215                 220                 
Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu
225                 230                 235                 240 
Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp
                245                 250                 255     
Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro
            260                 265                 270         
Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg
        275                 280                 285             
Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg
    290                 295                 300                 
Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile
305                 310                 315                 320 
Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys
                325                 330                 335     
His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser
            340                 345                 350         
Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg
        355                 360                 365             
Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr
    370                 375                 380                 
Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr
385                 390                 395                 400 
Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu
                405                 410                 415     
Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val
            420                 425                 430         
Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg
        435                 440                 445             
Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu
    450                 455                 460                 
Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln
465                 470                 475                 480 
Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr
                485                 490                 495     
Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala
            500                 505                 510         
Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr
        515                 520                 525             
Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser
    530                 535                 540                 
Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu
545                 550                 555                 560 
Gln Arg Glu Ala His Val Pro Leu Gly
                565                 


<210> 8919
<211> 745
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 228, 391, 402
<223> Xaa = Any Amino Acid

<400> 8919
Met Gly Val Glu Gln Arg Phe Ile Ile Arg Gly Leu Gly Gln Pro Ile
 1               5                  10                  15      
Val Phe Ser Ile Glu Lys Asn Asn Ser Asp Ser Cys Leu Lys Leu Thr
            20                  25                  30          
Thr Gln Arg Asp Phe Asp Phe Arg Ile Arg Lys Gly Pro Trp Val Arg
        35                  40                  45              
Lys Gln Asp Ile Leu Val Leu Asp Ser Ala Ala Val Leu Ala Arg Ser
    50                  55                  60                  
Leu Glu Arg Arg Cys Arg Ala Gly Ser Thr Gly Ser Ala Arg Arg Leu
65                  70                  75                  80  
Gly Trp Arg Pro Lys Val Pro Pro Leu Gly Asn Gln Ser Ala Phe Ala
                85                  90                  95      
Ser Ser Pro Val Pro Arg Gly Ser Val Ala Arg Ala Pro Arg Arg Gly
            100                 105                 110         
Arg Pro Arg Gln Pro Leu Ala Gly Ile Ala Gly Ala Asn Phe Pro Glu
        115                 120                 125             
Arg Glu Ala Cys Pro Ser Arg Pro Tyr Gly Lys Asp Gly Ser Glu Ser
    130                 135                 140                 
Glu Pro Pro Thr Pro Gly Pro Thr His Pro Tyr Ser Thr Leu Arg Gly
145                 150                 155                 160 
Trp Leu Pro Ala Arg Arg Gly Leu Leu Thr Phe Thr Asp Val Ala Ile
                165                 170                 175     
Glu Phe Ser Leu Met Glu Trp Gln Phe Leu Asp Thr Ala Gln Trp Asn
            180                 185                 190         
Leu Tyr Arg Asn Val Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Pro
        195                 200                 205             
Gly Ile Ala Val Ser Lys Pro Asp Leu Ile Ile Cys Leu Glu Gln Lys
    210                 215                 220                 
Lys Glu Pro Xaa Asn Met Lys Arg His Glu Met Val Asp Glu His Pro
225                 230                 235                 240 
Val Met Cys Ser His Phe Thr Gln Asp Phe Leu Pro Glu Lys Asn Ile
                245                 250                 255     
Glu Glu Ser Leu His Lys Ser Lys Ile Phe Gln Cys Asp Lys Tyr Val
            260                 265                 270         
Lys Val Phe His Lys Phe Ser His Leu Lys Ala Tyr Lys Ile Arg His
        275                 280                 285             
Ala Asp Lys Lys Pro Phe Lys Cys Lys Glu Cys Gly Lys Ser Phe Cys
    290                 295                 300                 
Met Leu Leu His Leu Ile Gln His Lys Arg Ile His Ala Thr Val Lys
305                 310                 315                 320 
Phe Tyr Lys Cys Lys Glu Cys Gly Lys Val Tyr Asn Arg Ser Ser Thr
                325                 330                 335     
Phe Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
            340                 345                 350         
Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Thr Asn Leu Thr Arg His
        355                 360                 365             
Lys Arg Ile His Thr Ala Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
    370                 375                 380                 
Lys Ala Phe Asn His Pro Xaa Asn Leu Thr Glu His Lys Lys Ile His
385                 390                 395                 400 
Thr Xaa Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
                405                 410                 415     
Gln Ser Ser Ile Leu Ser Lys His Lys Lys Thr His Thr Gly Glu Lys
            420                 425                 430         
Pro Tyr Lys Tyr Lys Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Asn
        435                 440                 445             
Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
    450                 455                 460                 
Glu Glu Cys Gly Lys Ala Phe His Gln Ser Ser Lys Leu Ala Lys His
465                 470                 475                 480 
Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Asp Cys Cys
                485                 490                 495     
Arg Ala Phe Thr Asp Ser Ala Thr Leu Thr Arg His Lys Arg Ile His
            500                 505                 510         
Thr Gly Glu Lys Pro Tyr Lys Tyr Glu Asp Cys Gly Lys Ala Phe Thr
        515                 520                 525             
Tyr Ser Thr Thr Leu Thr Arg His Lys Ile Ile His Thr Gly Glu Lys
    530                 535                 540                 
Pro Tyr Lys Tyr Lys Asp Cys Gly Lys Ala Phe Asn Glu Ser Ser Met
545                 550                 555                 560 
Leu Thr Thr His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
                565                 570                 575     
Glu Gln Cys Gly Lys Ala Phe Thr Asp Ser Ala Thr Leu Thr Arg Arg
            580                 585                 590         
Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Tyr Glu Asp Cys Gly
        595                 600                 605             
Lys Ala Phe Thr Asp Ser Ala Ile Leu Ser Arg Gln Asn Ser Tyr Trp
    610                 615                 620                 
Arg Lys Lys Pro Tyr Lys Cys Glu Asp Cys Gly Lys Ala Phe Asn Glu
625                 630                 635                 640 
Ser Ser Thr Leu Thr Ala His Lys Arg Ile His Thr Gly Glu Thr Pro
                645                 650                 655     
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn His Ser Ser His Leu
            660                 665                 670         
Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
        675                 680                 685             
Glu Tyr Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu Thr Lys His Lys
    690                 695                 700                 
Ile Ile Tyr Thr Gly Glu Gln Pro Tyr Lys Cys Glu Glu Cys Asp Lys
705                 710                 715                 720 
Ala Phe Asn Leu Ser Ala Ser Leu Ile Lys Asn Lys Lys Ile His Thr
                725                 730                 735     
Arg Glu Lys Leu Tyr Lys Thr Arg Lys
            740                 745 


<210> 8920
<211> 503
<212> PRT
<213> Homo sapiens

<400> 8920
Leu Gln Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu Trp His
 1               5                  10                  15      
Cys Leu Asp Thr Ala Gln Arg Asn Leu Tyr Arg Asn Val Met Leu Glu
            20                  25                  30          
Asn Tyr Ser Asn Leu Val Phe Leu Gly Ile Thr Val Ser Lys Pro Asp
        35                  40                  45              
Leu Ile Thr Cys Leu Glu Gln Gly Arg Lys Pro Leu Thr Met Lys Arg
    50                  55                  60                  
Asn Glu Met Ile Ala Lys Pro Ser Gly Arg Tyr Glu Asn Tyr Gly His
65                  70                  75                  80  
Asp Asn Leu Gln Phe Lys Lys Gly Cys Glu Ser Val Asp Glu Cys Lys
                85                  90                  95      
Val His Lys Arg Gly Tyr Asn Gly Leu Asn Gln Tyr Leu Thr Thr Thr
            100                 105                 110         
Gln Ser Lys Ile Phe Gln Cys Asp Lys Tyr Val Lys Val Ile His Lys
        115                 120                 125             
Phe Ser Asn Ser Asn Arg His Lys Ile Arg His Thr Gly Lys Lys Pro
    130                 135                 140                 
Phe Lys Cys Ile Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu
145                 150                 155                 160 
Thr Thr His Lys Lys Ile His Thr Gly Glu Lys Pro Phe Lys Cys Glu
                165                 170                 175     
Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser His Leu Thr Thr His Lys
            180                 185                 190         
Arg Ile His Thr Gly Glu Lys Arg Tyr Lys Cys Glu Asp Cys Gly Lys
        195                 200                 205             
Ala Phe Ser Arg Phe Ser Tyr Leu Thr Ala His Lys Ile Ile His Ser
    210                 215                 220                 
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Arg
225                 230                 235                 240 
Ser Ser Asn Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro
                245                 250                 255     
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Arg Ser Ser Ile Leu
            260                 265                 270         
Thr Ala His Lys Ile Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu
        275                 280                 285             
Glu Cys Gly Lys Ala Phe Lys His Pro Ser Val Leu Thr Thr His Lys
    290                 295                 300                 
Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg
305                 310                 315                 320 
Ala Phe Lys Tyr Phe Ser Ser Leu Thr Thr His Lys Ile Ile His Ser
                325                 330                 335     
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp
            340                 345                 350         
Ser Ser His Leu Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro
        355                 360                 365             
Tyr Lys Cys Glu Glu Cys Gly Glu Ala Phe Lys Tyr Ser Ser Ser Leu
    370                 375                 380                 
Thr Thr His Lys Ile Ile His Thr Gly Gln Gln Pro Phe Lys Cys Glu
385                 390                 395                 400 
Glu Cys Gly Lys Ala Phe Lys Cys Phe Ser Ile Leu Thr Thr His Lys
                405                 410                 415     
Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
            420                 425                 430         
Ala Phe Asn Ser Ser Ser His Leu Thr Ala His Lys Arg Ile His Thr
        435                 440                 445             
Gly Glu Lys Pro Tyr Lys Cys Glu Arg Cys Gly Lys Ala Phe Lys Arg
    450                 455                 460                 
Ser Phe Ile Leu Thr Arg His Lys Arg Ile His Thr Gly Glu Lys Pro
465                 470                 475                 480 
Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Lys Cys Pro Ser Thr Leu
                485                 490                 495     
Thr Thr His Lys Val Ile His
            500             


<210> 8921
<211> 557
<212> PRT
<213> Homo sapiens

<400> 8921
Met Gly Gly Phe Phe Cys Leu Phe Leu Pro Val Asp Val Met Leu Ala
 1               5                  10                  15      
Gly Ile Leu Val Gly Pro Leu Gln Phe Arg Asp Val Ala Ile Glu Phe
            20                  25                  30          
Ser Leu Glu Glu Trp His Cys Leu Asp Thr Ala Gln Arg Asn Leu Tyr
        35                  40                  45              
Arg Asn Val Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile
    50                  55                  60                  
Val Val Ser Lys Pro Asp Leu Ile Thr Cys Leu Glu Gln Gly Lys Lys
65                  70                  75                  80  
Pro Leu Thr Met Lys Lys His Glu Met Val Ala Asn Pro Ser Val Thr
                85                  90                  95      
Cys Ser His Phe Ala Arg Asp Leu Trp Pro Glu Gln Ser Ile Lys Asp
            100                 105                 110         
Ser Phe Gln Lys Val Thr Leu Arg Arg Tyr Glu Asn Tyr Gly His Asp
        115                 120                 125             
Asn Leu Gln Phe Lys Lys Gly Cys Glu Ser Val Asp Glu Cys Lys Val
    130                 135                 140                 
His Lys Arg Gly Tyr Asn Gly Leu Asn Gln Tyr Leu Thr Thr Thr Gln
145                 150                 155                 160 
Ser Lys Ile Phe Gln Cys Asp Lys Tyr Val Lys Val Ile His Lys Phe
                165                 170                 175     
Ser Asn Ser Asn Arg His Lys Ile Arg His Thr Gly Lys Lys Pro Phe
            180                 185                 190         
Lys Cys Ile Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu Thr
        195                 200                 205             
Thr His Lys Lys Ile His Thr Gly Glu Lys Pro Phe Lys Cys Glu Glu
    210                 215                 220                 
Cys Gly Lys Ala Phe Asn Trp Ser Ser His Leu Thr Thr His Lys Arg
225                 230                 235                 240 
Ile His Thr Gly Glu Lys Arg Tyr Lys Cys Glu Asp Cys Gly Lys Ala
                245                 250                 255     
Phe Ser Arg Phe Ser Tyr Leu Thr Ala His Lys Ile Ile His Ser Gly
            260                 265                 270         
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Arg Ser
        275                 280                 285             
Ser Asn Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr
    290                 295                 300                 
Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Arg Ser Ser Ile Leu Thr
305                 310                 315                 320 
Ala His Lys Ile Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu
                325                 330                 335     
Cys Gly Lys Ala Phe Lys His Pro Ser Val Leu Thr Thr His Lys Arg
            340                 345                 350         
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Ala
        355                 360                 365             
Phe Lys Tyr Phe Ser Ser Leu Thr Thr His Lys Ile Ile His Ser Gly
    370                 375                 380                 
Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser
385                 390                 395                 400 
Ser His Leu Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr
                405                 410                 415     
Lys Cys Glu Glu Cys Gly Glu Ala Phe Lys Tyr Ser Ser Ser Leu Thr
            420                 425                 430         
Thr His Lys Ile Ile His Thr Gly Gln Gln Pro Phe Lys Cys Glu Glu
        435                 440                 445             
Cys Gly Lys Ala Phe Lys Cys Phe Ser Ile Leu Thr Thr His Lys Arg
    450                 455                 460                 
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala
465                 470                 475                 480 
Phe Asn Ser Ser Ser His Leu Thr Ala His Lys Arg Ile His Thr Gly
                485                 490                 495     
Glu Lys Pro Tyr Lys Cys Glu Arg Cys Gly Lys Ala Phe Lys Arg Ser
            500                 505                 510         
Phe Ile Leu Thr Arg His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr
        515                 520                 525             
Lys Cys Glu Glu Cys Gly Lys Gly Phe Lys Cys Pro Ser Thr Leu Thr
    530                 535                 540                 
Thr His Lys Ile Ile His Ala Gly Lys Lys Pro Asn Lys
545                 550                 555         


<210> 8922
<211> 537
<212> PRT
<213> Homo sapiens

<400> 8922
Leu Gln Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu Trp His
 1               5                  10                  15      
Cys Leu Asp Thr Ala Gln Arg Asn Leu Tyr Arg Asn Val Met Leu Glu
            20                  25                  30          
Asn Tyr Ser Asn Leu Val Phe Leu Glu Gln Ser Met Lys Asp Ser Phe
        35                  40                  45              
Gln Lys Val Val Leu Arg Arg Tyr Glu Lys Cys Glu His Asp Asn Leu
    50                  55                  60                  
Gln Leu Lys Lys Gly Cys Ile Ser Val Asp Glu Phe Thr Cys Ser His
65                  70                  75                  80  
Phe Ala Arg Asp Leu Trp Pro Glu Gln Ser Ile Lys Asp Ser Phe Gln
                85                  90                  95      
Lys Val Thr Leu Arg Arg Tyr Glu Asn Tyr Gly His Asp Asn Leu Gln
            100                 105                 110         
Phe Lys Lys Gly Cys Glu Ser Val Asp Glu Cys Lys Val His Lys Arg
        115                 120                 125             
Gly Tyr Asn Gly Leu Asn Gln Tyr Leu Thr Thr Thr Gln Ser Lys Ile
    130                 135                 140                 
Phe Gln Cys Asp Lys Tyr Val Lys Val Ile His Lys Phe Ser Asn Ser
145                 150                 155                 160 
Asn Arg His Lys Ile Arg His Thr Gly Lys Lys Pro Phe Lys Cys Ile
                165                 170                 175     
Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu Thr Thr His Lys
            180                 185                 190         
Lys Ile His Thr Gly Glu Lys Pro Phe Lys Cys Glu Glu Cys Gly Lys
        195                 200                 205             
Ala Phe Asn Trp Ser Ser His Leu Thr Thr His Lys Arg Ile His Thr
    210                 215                 220                 
Gly Glu Lys Arg Tyr Lys Cys Glu Asp Cys Gly Lys Ala Phe Ser Arg
225                 230                 235                 240 
Phe Ser Tyr Leu Thr Ala His Lys Ile Ile His Ser Gly Glu Lys Pro
                245                 250                 255     
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Arg Ser Ser Asn Leu
            260                 265                 270         
Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
        275                 280                 285             
Glu Cys Gly Lys Ala Phe Lys Arg Ser Ser Ile Leu Thr Ala His Lys
    290                 295                 300                 
Ile Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
305                 310                 315                 320 
Ala Phe Lys His Pro Ser Val Leu Thr Thr His Lys Arg Ile His Thr
                325                 330                 335     
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Ala Phe Lys Tyr
            340                 345                 350         
Phe Ser Ser Leu Thr Thr His Lys Ile Ile His Ser Gly Glu Lys Pro
        355                 360                 365             
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser His Leu
    370                 375                 380                 
Thr Thr His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
385                 390                 395                 400 
Glu Cys Gly Glu Ala Phe Lys Tyr Ser Ser Ser Leu Thr Thr His Lys
                405                 410                 415     
Ile Ile His Thr Gly Gln Gln Pro Phe Lys Cys Glu Glu Cys Gly Lys
            420                 425                 430         
Ala Phe Lys Cys Phe Ser Ile Leu Thr Thr His Lys Arg Ile His Thr
        435                 440                 445             
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Ser
    450                 455                 460                 
Ser Ser His Leu Thr Ala His Lys Arg Ile His Thr Gly Glu Lys Pro
465                 470                 475                 480 
Tyr Lys Cys Glu Arg Cys Gly Lys Ala Phe Lys Arg Ser Phe Ile Leu
                485                 490                 495     
Thr Arg His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
            500                 505                 510         
Glu Cys Gly Lys Gly Phe Lys Cys Pro Ser Thr Leu Thr Thr His Asn
        515                 520                 525             
Ser Tyr Trp Arg Glu Thr Ile Asn Val
    530                 535         


<210> 8923
<211> 272
<212> PRT
<213> Homo sapiens

<400> 8923
Met His Leu Arg Leu Ile Ser Trp Leu Phe Ile Ile Leu Asn Phe Met
 1               5                  10                  15      
Glu Tyr Ile Gly Ser Gln Asn Ala Ser Arg Gly Arg Arg Gln Arg Arg
            20                  25                  30          
Met His Pro Asn Val Ser Gln Gly Cys Gln Gly Gly Cys Ala Thr Cys
        35                  40                  45              
Ser Asp Tyr Asn Gly Cys Leu Ser Cys Lys Pro Arg Leu Phe Phe Ala
    50                  55                  60                  
Leu Glu Arg Ile Gly Met Lys Gln Ile Gly Val Cys Leu Ser Ser Cys
65                  70                  75                  80  
Pro Ser Gly Tyr Tyr Gly Thr Arg Tyr Pro Asp Ile Asn Lys Cys Thr
                85                  90                  95      
Lys Cys Lys Ala Asp Cys Asp Thr Cys Phe Asn Lys Asn Phe Cys Thr
            100                 105                 110         
Lys Cys Lys Ser Gly Phe Tyr Leu His Leu Gly Lys Cys Leu Asp Asn
        115                 120                 125             
Cys Pro Glu Gly Leu Glu Ala Asn Asn His Thr Met Glu Cys Val Ser
    130                 135                 140                 
Ile Val His Cys Glu Val Ser Glu Trp Asn Pro Trp Ser Pro Cys Thr
145                 150                 155                 160 
Lys Lys Gly Lys Thr Cys Gly Phe Lys Arg Gly Thr Glu Thr Arg Val
                165                 170                 175     
Arg Glu Ile Ile Gln His Pro Ser Ala Lys Gly Asn Leu Cys Pro Pro
            180                 185                 190         
Thr Asn Glu Thr Arg Lys Cys Thr Val Gln Arg Lys Lys Cys Gln Lys
        195                 200                 205             
Gly Glu Arg Gly Lys Lys Gly Arg Glu Arg Lys Arg Lys Lys Pro Asn
    210                 215                 220                 
Lys Gly Glu Ser Lys Glu Ala Ile Pro Asp Ser Lys Ser Leu Glu Ser
225                 230                 235                 240 
Ser Lys Glu Ile Pro Glu Gln Arg Glu Asn Lys Gln Gln Gln Lys Lys
                245                 250                 255     
Arg Lys Val Gln Asp Lys Gln Lys Ser Val Ser Val Ser Thr Val His
            260                 265                 270         


<210> 8924
<211> 584
<212> PRT
<213> Homo sapiens

<400> 8924
Met Asp Leu Leu Trp Met Pro Leu Leu Leu Val Ala Ala Cys Val Ser
 1               5                  10                  15      
Ala Val His Ser Ser Pro Glu Val Asn Ala Gly Val Ser Ser Ile His
            20                  25                  30          
Ile Thr Lys Pro Val His Ile Leu Glu Glu Arg Ser Leu Leu Val Leu
        35                  40                  45              
Thr Pro Ala Gly Leu Thr Gln Met Leu Asn Gln Thr Arg Phe Leu Met
    50                  55                  60                  
Val Leu Phe His Asn Pro Ser Ser Lys Gln Ser Arg Asn Leu Ala Glu
65                  70                  75                  80  
Glu Leu Gly Lys Ala Val Glu Ile Met Gly Lys Gly Lys Asn Gly Ile
                85                  90                  95      
Gly Phe Gly Lys Val Asp Ile Thr Ile Glu Lys Glu Leu Gln Gln Glu
            100                 105                 110         
Phe Gly Ile Thr Lys Ala Pro Glu Leu Lys Leu Phe Phe Glu Gly Asn
        115                 120                 125             
Arg Ser Glu Pro Ile Ser Cys Lys Gly Val Val Glu Ser Ala Ala Leu
    130                 135                 140                 
Val Val Trp Leu Arg Arg Gln Ile Ser Gln Lys Ala Phe Leu Phe Asn
145                 150                 155                 160 
Ser Ser Glu Gln Val Ala Glu Phe Val Ile Ser Arg Pro Leu Val Ile
                165                 170                 175     
Val Gly Phe Phe Gln Asp Leu Glu Glu Glu Val Ala Glu Leu Phe Tyr
            180                 185                 190         
Asp Val Ile Lys Asp Phe Pro Glu Leu Thr Phe Gly Val Ile Thr Ile
        195                 200                 205             
Gly Asn Val Ile Gly Arg Phe His Val Thr Leu Asp Ser Val Leu Val
    210                 215                 220                 
Phe Lys Lys Gly Lys Ile Val Asn Arg Gln Lys Leu Ile Asn Asp Ser
225                 230                 235                 240 
Thr Asn Lys Gln Glu Leu Asn Arg Val Ile Lys Gln His Leu Thr Asp
                245                 250                 255     
Phe Val Ile Glu Tyr Asn Thr Glu Asn Lys Asp Leu Ile Ser Glu Leu
            260                 265                 270         
His Ile Met Ser His Met Leu Leu Phe Val Ser Lys Ser Ser Glu Ser
        275                 280                 285             
Tyr Gly Ile Ile Ile Gln His Tyr Lys Leu Ala Ser Lys Glu Phe Gln
    290                 295                 300                 
Asn Lys Ile Leu Phe Ile Leu Val Asp Ala Asp Glu Pro Arg Asn Gly
305                 310                 315                 320 
Arg Val Phe Lys Tyr Phe Arg Val Thr Glu Val Asp Ile Pro Ser Val
                325                 330                 335     
Gln Ile Leu Asn Leu Ser Ser Asp Ala Arg Tyr Lys Met Pro Ser Asp
            340                 345                 350         
Asp Ile Thr Tyr Glu Ser Leu Lys Lys Phe Gly Arg Ser Phe Leu Ser
        355                 360                 365             
Lys Asn Ala Thr Lys His Gln Ser Ser Glu Glu Ile Pro Lys Tyr Trp
    370                 375                 380                 
Asp Gln Gly Leu Val Lys Gln Leu Val Gly Lys Asn Phe Asn Val Val
385                 390                 395                 400 
Val Phe Asp Lys Glu Lys Asp Val Phe Val Met Phe Tyr Ala Pro Trp
                405                 410                 415     
Ser Lys Lys Cys Lys Met Leu Phe Pro Leu Leu Glu Glu Leu Gly Arg
            420                 425                 430         
Lys Tyr Gln Asn His Ser Thr Ile Ile Ile Ala Lys Ile Asp Val Thr
        435                 440                 445             
Ala Asn Asp Ile Gln Leu Met Tyr Leu Asp Arg Tyr Pro Phe Phe Arg
    450                 455                 460                 
Leu Phe Pro Ser Gly Ser Gln Gln Ala Val Leu Tyr Lys Gly Glu His
465                 470                 475                 480 
Thr Leu Lys Gly Phe Ser Asp Phe Leu Glu Ser His Ile Lys Thr Lys
                485                 490                 495     
Ile Glu Asp Glu Asp Glu Leu Leu Ser Val Glu Gln Asn Glu Val Ile
            500                 505                 510         
Glu Glu Glu Val Leu Ala Glu Glu Lys Glu Val Pro Met Met Arg Lys
        515                 520                 525             
Gly Leu Pro Glu Gln Gln Ser Pro Glu Leu Glu Asn Met Thr Lys Tyr
    530                 535                 540                 
Val Ser Lys Leu Glu Glu Pro Ala Gly Lys Lys Lys Thr Ser Glu Glu
545                 550                 555                 560 
Val Val Val Val Val Ala Lys Pro Lys Gly Pro Pro Val Gln Lys Lys
                565                 570                 575     
Lys Pro Lys Val Lys Glu Glu Leu
            580                 


<210> 8925
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8925
Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu Ala Leu Val Ser
 1               5                  10                  15      
Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly Tyr Gly Asn Pro
            20                  25                  30          
Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys Gly Ala Pro Gly
        35                  40                  45              
Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln Asn Tyr Thr Leu
    50                  55                  60                  
Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala Gly Ser Gln Gly
65                  70                  75                  80  
Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val Gly Glu Gly Gly
                85                  90                  95      
Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg Cys Gln Thr Asp
            100                 105                 110         
Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu Gly Asp Gly Ile
        115                 120                 125             
Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn Cys Cys Phe Trp
    130                 135                 140                 
Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly Tyr His Val Tyr
145                 150                 155                 160 
Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr Cys Thr Asp Pro
                165                 170                 175     
Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg Pro Glu Glu Glu
            180                 185                 190         
Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys Arg Gln Asp Leu
        195                 200                 205             
Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu Asp Cys Gly Pro
    210                 215                 220                 
Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu Gly Gly Leu Gly
225                 230                 235                 240 
Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro Asn Cys Ser Ser
                245                 250                 255     
Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val Thr Ser Pro Val
            260                 265                 270         
Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn Gln Thr His Ala
        275                 280                 285             
Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe Ile Ile Arg Asp
    290                 295                 300                 
Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro Leu Asp Met Lys
305                 310                 315                 320 
Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser Ser Leu Asn Val
                325                 330                 335     
Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met Ala Leu Phe Gln
            340                 345                 350         
Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala Val Glu Leu Ser
        355                 360                 365             
Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu Gln Gly Asp Thr
    370                 375                 380                 
Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala Thr Pro Thr Glu
385                 390                 395                 400 
Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg Asn Ser Cys Ser
                405                 410                 415     
Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn Gly Gln Ser Ser
            420                 425                 430         
Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala Gly His Tyr Asp
        435                 440                 445             
Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp Ser Leu Asn Glu
    450                 455                 460                 
Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg Ser Glu Val Pro
465                 470                 475                 480 
Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro Ile Thr Arg Arg
                485                 490                 495     
Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro Ser Thr Ala Gly
            500                 505                 510         
Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val Leu Leu Ala Trp
        515                 520                 525             
Leu Phe
    530 


<210> 8926
<211> 380
<212> PRT
<213> Homo sapiens

<400> 8926
Met Val Gly Ser Gly Leu Leu Trp Leu Ala Leu Val Ser Cys Ile Leu
 1               5                  10                  15      
Thr Gln Ala Ser Ala Val Gln Arg Asp Pro Ser Thr Val Glu Asp Lys
            20                  25                  30          
Cys Glu Lys Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser
        35                  40                  45              
Thr Trp Gly Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp Val His
    50                  55                  60                  
Ser Leu Gln Pro Gln Leu Asp Cys Gly Pro Arg Glu Ile Lys Val Lys
65                  70                  75                  80  
Val Asp Lys Cys Leu Leu Gly Gly Leu Gly Leu Gly Glu Glu Val Ile
                85                  90                  95      
Ala Tyr Leu Arg Asp Pro Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu
            100                 105                 110         
Arg Asn Trp Val Ser Val Thr Ser Pro Val Gln Ala Ser Ala Cys Arg
        115                 120                 125             
Asn Ile Leu Glu Arg Asn Gln Thr His Ala Ile Tyr Lys Asn Thr Leu
    130                 135                 140                 
Ser Leu Val Asn Asp Phe Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn
145                 150                 155                 160 
Phe Gln Cys Ala Tyr Pro Leu Asp Met Lys Val Ser Leu Gln Ala Ala
                165                 170                 175     
Leu Gln Pro Ile Val Ser Ser Leu Asn Val Ser Val Asp Gly Asn Gly
            180                 185                 190         
Glu Phe Ile Val Arg Met Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn
        195                 200                 205             
Pro Tyr Glu Gly Asp Ala Val Glu Leu Ser Val Glu Ser Val Leu Tyr
    210                 215                 220                 
Val Gly Ala Ile Leu Glu Gln Gly Asp Thr Ser Arg Phe Asn Leu Val
225                 230                 235                 240 
Leu Arg Asn Cys Tyr Ala Thr Pro Thr Glu Asp Lys Ala Asp Leu Val
                245                 250                 255     
Lys Tyr Phe Ile Ile Arg Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr
            260                 265                 270         
Ile His Val Glu Glu Asn Gly Gln Ser Ser Glu Ser Arg Phe Ser Val
        275                 280                 285             
Gln Met Phe Met Phe Ala Gly His Tyr Asp Leu Val Phe Leu His Cys
    290                 295                 300                 
Glu Ile His Leu Cys Asp Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys
305                 310                 315                 320 
Ser Arg Ser Gln Val Arg Ser Glu Val Pro Ala Ile Asp Leu Ala Arg
                325                 330                 335     
Val Leu Asp Leu Gly Pro Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly
            340                 345                 350         
Val Met Asn Gly Thr Pro Ser Thr Ala Gly Phe Leu Val Ala Trp Pro
        355                 360                 365             
Met Val Leu Leu Thr Val Leu Leu Ala Trp Leu Phe
    370                 375                 380 


<210> 8927
<211> 261
<212> PRT
<213> Homo sapiens

<400> 8927
Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro
 1               5                  10                  15      
Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly
            20                  25                  30          
Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys
        35                  40                  45              
Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr
    50                  55                  60                  
Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser
65                  70                  75                  80  
Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr
                85                  90                  95      
Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys
            100                 105                 110         
Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn
        115                 120                 125             
Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp
    130                 135                 140                 
Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val
145                 150                 155                 160 
Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala
                165                 170                 175     
Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys
            180                 185                 190         
Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys
        195                 200                 205             
Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile
    210                 215                 220                 
Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu
225                 230                 235                 240 
Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala
                245                 250                 255     
Glu Lys Glu Glu Leu
            260     


<210> 8928
<211> 2351
<212> PRT
<213> Homo sapiens

<400> 8928
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe
 1               5                  10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro
        755                 760                 765             
Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp
    770                 775                 780                 
Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys
785                 790                 795                 800 
Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser
                805                 810                 815     
Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr
            820                 825                 830         
Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn
        835                 840                 845             
Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly
    850                 855                 860                 
Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu
865                 870                 875                 880 
Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys
                885                 890                 895     
Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn
            900                 905                 910         
Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met
        915                 920                 925             
Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys
    930                 935                 940                 
Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu
945                 950                 955                 960 
Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu
                965                 970                 975     
Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe
            980                 985                 990         
Lys Gly Lys Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala
        995                 1000                1005            
Leu Phe Lys Val Ser Ile Ser Leu Leu Lys Thr Asn Lys Thr Ser Asn
    1010                1015                1020                
Asn Ser Ala Thr Asn Arg Lys Thr His Ile Asp Gly Pro Ser Leu Leu
1025                1030                1035                1040
Ile Glu Asn Ser Pro Ser Val Trp Gln Asn Ile Leu Glu Ser Asp Thr
                1045                1050                1055    
Glu Phe Lys Lys Val Thr Pro Leu Ile His Asp Arg Met Leu Met Asp
            1060                1065                1070        
Lys Asn Ala Thr Ala Leu Arg Leu Asn His Met Ser Asn Lys Thr Thr
        1075                1080                1085            
Ser Ser Lys Asn Met Glu Met Val Gln Gln Lys Lys Glu Gly Pro Ile
    1090                1095                1100                
Pro Pro Asp Ala Gln Asn Pro Asp Met Ser Phe Phe Lys Met Leu Phe
1105                1110                1115                1120
Leu Pro Glu Ser Ala Arg Trp Ile Gln Arg Thr His Gly Lys Asn Ser
                1125                1130                1135    
Leu Asn Ser Gly Gln Gly Pro Ser Pro Lys Gln Leu Val Ser Leu Gly
            1140                1145                1150        
Pro Glu Lys Ser Val Glu Gly Gln Asn Phe Leu Ser Glu Lys Asn Lys
        1155                1160                1165            
Val Val Val Gly Lys Gly Glu Phe Thr Lys Asp Val Gly Leu Lys Glu
    1170                1175                1180                
Met Val Phe Pro Ser Ser Arg Asn Leu Phe Leu Thr Asn Leu Asp Asn
1185                1190                1195                1200
Leu His Glu Asn Asn Thr His Asn Gln Glu Lys Lys Ile Gln Glu Glu
                1205                1210                1215    
Ile Glu Lys Lys Glu Thr Leu Ile Gln Glu Asn Val Val Leu Pro Gln
            1220                1225                1230        
Ile His Thr Val Thr Gly Thr Lys Asn Phe Met Lys Asn Leu Phe Leu
        1235                1240                1245            
Leu Ser Thr Arg Gln Asn Val Glu Gly Ser Tyr Asp Gly Ala Tyr Ala
    1250                1255                1260                
Pro Val Leu Gln Asp Phe Arg Ser Leu Asn Asp Ser Thr Asn Arg Thr
1265                1270                1275                1280
Lys Lys His Thr Ala His Phe Ser Lys Lys Gly Glu Glu Glu Asn Leu
                1285                1290                1295    
Glu Gly Leu Gly Asn Gln Thr Lys Gln Ile Val Glu Lys Tyr Ala Cys
            1300                1305                1310        
Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln Gln Asn Phe Val Thr Gln
        1315                1320                1325            
Arg Ser Lys Arg Ala Leu Lys Gln Phe Arg Leu Pro Leu Glu Glu Thr
    1330                1335                1340                
Glu Leu Glu Lys Arg Ile Ile Val Asp Asp Thr Ser Thr Gln Trp Ser
1345                1350                1355                1360
Lys Asn Met Lys His Leu Thr Pro Ser Thr Leu Thr Gln Ile Asp Tyr
                1365                1370                1375    
Asn Glu Lys Glu Lys Gly Ala Ile Thr Gln Ser Pro Leu Ser Asp Cys
            1380                1385                1390        
Leu Thr Arg Ser His Ser Ile Pro Gln Ala Asn Arg Ser Pro Leu Pro
        1395                1400                1405            
Ile Ala Lys Val Ser Ser Phe Pro Ser Ile Arg Pro Ile Tyr Leu Thr
    1410                1415                1420                
Arg Val Leu Phe Gln Asp Asn Ser Ser His Leu Pro Ala Ala Ser Tyr
1425                1430                1435                1440
Arg Lys Lys Asp Ser Gly Val Gln Glu Ser Ser His Phe Leu Gln Gly
                1445                1450                1455    
Ala Lys Lys Asn Asn Leu Ser Leu Ala Ile Leu Thr Leu Glu Met Thr
            1460                1465                1470        
Gly Asp Gln Arg Glu Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser
        1475                1480                1485            
Val Thr Tyr Lys Lys Val Glu Asn Thr Val Leu Pro Lys Pro Asp Leu
    1490                1495                1500                
Pro Lys Thr Ser Gly Lys Val Glu Leu Leu Pro Lys Val His Ile Tyr
1505                1510                1515                1520
Gln Lys Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His
                1525                1530                1535    
Leu Asp Leu Val Glu Gly Ser Leu Leu Gln Gly Thr Glu Gly Ala Ile
            1540                1545                1550        
Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val Pro Phe Leu Arg Val
        1555                1560                1565            
Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser Lys Leu Leu Asp Pro Leu
    1570                1575                1580                
Ala Trp Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys
1585                1590                1595                1600
Ser Gln Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr
                1605                1610                1615    
Ile Leu Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile
            1620                1625                1630        
Asn Glu Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln
        1635                1640                1645            
Gly Arg Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg
    1650                1655                1660                
His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu
1665                1670                1675                1680
Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe
                1685                1690                1695    
Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys
            1700                1705                1710        
Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr
        1715                1720                1725            
Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly
    1730                1735                1740                
Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly
1745                1750                1755                1760
Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly
                1765                1770                1775    
Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val
            1780                1785                1790        
Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu
        1795                1800                1805            
Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn
    1810                1815                1820                
Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His
1825                1830                1835                1840
His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr
                1845                1850                1855    
Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly
            1860                1865                1870        
Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg
        1875                1880                1885            
Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu
    1890                1895                1900                
Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala
1905                1910                1915                1920
Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg
                1925                1930                1935    
Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val
            1940                1945                1950        
Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser
        1955                1960                1965            
Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val
    1970                1975                1980                
Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly
1985                1990                1995                2000
Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg
                2005                2010                2015    
Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu
            2020                2025                2030        
Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser
        2035                2040                2045            
Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln
    2050                2055                2060                
Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala
2065                2070                2075                2080
Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala
                2085                2090                2095    
Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe
            2100                2105                2110        
Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly
        2115                2120                2125            
Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val
    2130                2135                2140                
Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn
2145                2150                2155                2160
Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser
                2165                2170                2175    
Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser
            2180                2185                2190        
Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln
        2195                2200                2205            
Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro
    2210                2215                2220                
Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro
2225                2230                2235                2240
Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr
                2245                2250                2255    
Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr
            2260                2265                2270        
Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His
        2275                2280                2285            
Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly
    2290                2295                2300                
Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu
2305                2310                2315                2320
Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile
                2325                2330                2335    
Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr
            2340                2345                2350    


<210> 8929
<211> 551
<212> PRT
<213> Homo sapiens

<400> 8929
Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln
 1               5                  10                  15      
Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln
            20                  25                  30          
Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg
        35                  40                  45              
Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly
    50                  55                  60                  
Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg
65                  70                  75                  80  
Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val
                85                  90                  95      
Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp
            100                 105                 110         
Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr
        115                 120                 125             
Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu
    130                 135                 140                 
Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr
145                 150                 155                 160 
Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu
                165                 170                 175     
Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr
            180                 185                 190         
Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly
        195                 200                 205             
Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr
    210                 215                 220                 
Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr
225                 230                 235                 240 
Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr
                245                 250                 255     
Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro
            260                 265                 270         
Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu
        275                 280                 285             
Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val
    290                 295                 300                 
Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu
305                 310                 315                 320 
Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln
                325                 330                 335     
Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg
            340                 345                 350         
Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu
        355                 360                 365             
Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn
    370                 375                 380                 
Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly
385                 390                 395                 400 
Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr
                405                 410                 415     
Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu
            420                 425                 430         
Gly Thr Gly Val Val Pro Ala Ala Leu Gly Gly Ala Gly Val Met Ala
        435                 440                 445             
Leu Leu Cys Ile Cys Leu Cys Leu Ile Phe Phe Leu Ile Val Lys Ala
    450                 455                 460                 
Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys Met Asp Asp Glu Asp
465                 470                 475                 480 
Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg Lys Lys Pro Trp Pro
                485                 490                 495     
Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly Asp Ala Pro Pro Leu
            500                 505                 510         
Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu Ser Phe Ser Glu Met
        515                 520                 525             
Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr
    530                 535                 540                 
Ser Glu Ile Lys Thr Ser Lys
545                 550     


<210> 8930
<211> 540
<212> PRT
<213> Homo sapiens

<400> 8930
Met Trp Leu Leu Arg Cys Val Leu Leu Cys Val Ser Leu Ser Leu Ala
 1               5                  10                  15      
Val Ser Gly Gln His Lys Pro Glu Ala Pro Asp Tyr Ser Ser Val Leu
            20                  25                  30          
His Cys Gly Pro Trp Ser Phe Gln Phe Ala Val Asn Leu Asn Gln Glu
        35                  40                  45              
Ala Thr Ser Pro Pro Val Leu Ile Ala Trp Asp Asn Gln Gly Leu Leu
    50                  55                  60                  
His Glu Leu Gln Asn Asp Ser Asp Cys Gly Thr Trp Ile Arg Lys Gly
65                  70                  75                  80  
Pro Gly Ser Ser Val Val Leu Glu Ala Thr Tyr Ser Ser Cys Tyr Val
                85                  90                  95      
Thr Glu Trp Asp Ser His Tyr Ile Met Pro Val Gly Val Glu Gly Ala
            100                 105                 110         
Gly Ala Ala Glu His Lys Val Val Thr Glu Arg Lys Leu Leu Lys Cys
        115                 120                 125             
Pro Met Asp Leu Leu Ala Arg Asp Ala Pro Asp Thr Asp Trp Cys Asp
    130                 135                 140                 
Ser Ile Pro Ala Arg Asp Arg Leu Pro Cys Ala Pro Ser Pro Ile Ser
145                 150                 155                 160 
Arg Gly Asp Cys Glu Gly Leu Gly Cys Cys Tyr Ser Ser Glu Glu Val
                165                 170                 175     
Asn Ser Cys Tyr Tyr Gly Asn Thr Val Thr Leu His Cys Thr Arg Glu
            180                 185                 190         
Gly His Phe Ser Ile Ala Val Ser Arg Asn Val Thr Ser Pro Pro Leu
        195                 200                 205             
Leu Leu Asp Ser Val Arg Leu Ala Leu Arg Asn Asp Ser Ala Cys Asn
    210                 215                 220                 
Pro Val Met Ala Thr Gln Ala Phe Val Leu Phe Gln Phe Pro Phe Thr
225                 230                 235                 240 
Ser Cys Gly Thr Thr Arg Gln Ile Thr Gly Asp Arg Ala Val Tyr Glu
                245                 250                 255     
Asn Glu Leu Val Ala Thr Arg Asp Val Lys Asn Gly Ser Arg Gly Ser
            260                 265                 270         
Val Thr Arg Asp Ser Ile Phe Arg Leu His Val Ser Cys Ser Tyr Ser
        275                 280                 285             
Val Ser Ser Asn Ser Leu Pro Ile Asn Val Gln Val Phe Thr Leu Pro
    290                 295                 300                 
Pro Pro Phe Pro Glu Thr Gln Pro Gly Pro Leu Thr Leu Glu Leu Gln
305                 310                 315                 320 
Ile Ala Lys Asp Lys Asn Tyr Gly Ser Tyr Tyr Gly Val Gly Asp Tyr
                325                 330                 335     
Pro Val Val Lys Leu Leu Arg Asp Pro Ile Tyr Val Glu Val Ser Ile
            340                 345                 350         
Leu His Arg Thr Asp Pro Tyr Leu Gly Leu Leu Leu Gln Gln Cys Trp
        355                 360                 365             
Ala Thr Pro Ser Thr Asp Pro Leu Ser Gln Pro Gln Trp Pro Ile Leu
    370                 375                 380                 
Val Lys Gly Cys Pro Tyr Ile Gly Asp Asn Tyr Gln Thr Gln Leu Ile
385                 390                 395                 400 
Pro Val Gln Lys Ala Leu Asp Leu Pro Phe Pro Ser His His Gln Arg
                405                 410                 415     
Phe Ser Ile Phe Thr Phe Ser Phe Val Asn Pro Thr Val Glu Lys Gln
            420                 425                 430         
Ala Leu Arg Gly Pro Val His Leu His Cys Ser Val Ser Val Cys Gln
        435                 440                 445             
Pro Ala Glu Thr Pro Ser Cys Val Val Thr Cys Pro Asp Leu Ser Arg
    450                 455                 460                 
Arg Arg Asn Phe Asp Asn Ser Ser Gln Asn Thr Thr Ala Ser Val Ser
465                 470                 475                 480 
Ser Lys Gly Pro Met Ile Leu Leu Gln Ala Thr Lys Asp Pro Pro Glu
                485                 490                 495     
Lys Leu Arg Val Pro Val Asp Ser Lys Val Leu Trp Val Ala Gly Leu
            500                 505                 510         
Ser Gly Thr Leu Ile Leu Gly Ala Leu Leu Val Ser Tyr Leu Ala Val
        515                 520                 525             
Lys Lys Gln Lys Ser Cys Pro Asp Gln Met Cys Gln
    530                 535                 540 


<210> 8931
<211> 660
<212> PRT
<213> Homo sapiens

<400> 8931
Met Leu Val Cys Tyr Ser Val Leu Ala Cys Glu Ile Leu Trp Asp Leu
 1               5                  10                  15      
Pro Cys Ser Ile Met Gly Ser Pro Leu Gly His Phe Thr Trp Asp Lys
            20                  25                  30          
Tyr Leu Lys Glu Thr Cys Ser Val Pro Ala Pro Val His Cys Phe Lys
        35                  40                  45              
Gln Ser Tyr Thr Pro Pro Ser Asn Glu Phe Lys Ile Ser Met Lys Leu
    50                  55                  60                  
Glu Ala Gln Asp Pro Arg Asn Thr Thr Ser Thr Cys Ile Ala Thr Val
65                  70                  75                  80  
Val Gly Leu Thr Gly Ala Arg Leu Arg Leu Arg Leu Asp Gly Ser Asp
                85                  90                  95      
Asn Lys Asn Asp Phe Trp Arg Leu Val Asp Ser Ala Glu Ile Gln Pro
            100                 105                 110         
Ile Gly Asn Cys Glu Lys Asn Gly Gly Met Leu Gln Pro Pro Leu Gly
        115                 120                 125             
Phe Arg Leu Asn Ala Ser Ser Trp Pro Met Phe Leu Leu Lys Thr Leu
    130                 135                 140                 
Asn Gly Ala Glu Met Ala Pro Ile Arg Ile Phe His Lys Glu Pro Pro
145                 150                 155                 160 
Ser Pro Ser His Asn Phe Phe Lys Met Gly Met Lys Leu Glu Ala Val
                165                 170                 175     
Asp Arg Lys Asn Pro His Phe Ile Cys Pro Ala Thr Ile Gly Glu Val
            180                 185                 190         
Arg Gly Ser Glu Val Leu Val Thr Phe Asp Gly Trp Arg Gly Ala Phe
        195                 200                 205             
Asp Tyr Trp Cys Arg Phe Asp Ser Arg Asp Ile Phe Pro Val Gly Trp
    210                 215                 220                 
Cys Ser Leu Thr Gly Asp Asn Leu Gln Pro Pro Gly Thr Lys Val Val
225                 230                 235                 240 
Ile Pro Lys Asn Pro Tyr Pro Ala Ser Asp Val Asn Thr Glu Lys Pro
                245                 250                 255     
Ser Ile His Ser Ser Thr Lys Thr Val Leu Glu His Gln Pro Gly Gln
            260                 265                 270         
Arg Gly Arg Lys Pro Gly Lys Lys Arg Gly Arg Thr Pro Lys Thr Leu
        275                 280                 285             
Ile Ser His Pro Ile Ser Ala Pro Ser Lys Thr Ala Glu Pro Leu Lys
    290                 295                 300                 
Phe Pro Lys Lys Arg Gly Pro Lys Pro Gly Ser Lys Arg Lys Pro Arg
305                 310                 315                 320 
Thr Leu Leu Asn Pro Pro Pro Ala Ser Pro Thr Thr Ser Thr Pro Glu
                325                 330                 335     
Pro Asp Thr Ser Thr Val Pro Gln Asp Ala Ala Thr Ile Pro Ser Ser
            340                 345                 350         
Ala Met Gln Ala Pro Thr Val Cys Ile Tyr Leu Asn Lys Asn Gly Ser
        355                 360                 365             
Thr Gly Pro His Leu Asp Lys Lys Lys Val Gln Gln Leu Pro Asp His
    370                 375                 380                 
Phe Gly Pro Ala Arg Ala Ser Val Val Leu Gln Gln Ala Val Gln Ala
385                 390                 395                 400 
Cys Ile Asp Cys Ala Tyr His Gln Lys Thr Val Phe Ser Phe Leu Lys
                405                 410                 415     
Gln Gly His Gly Gly Glu Val Ile Ser Ala Val Phe Asp Arg Glu Gln
            420                 425                 430         
His Thr Leu Asn Leu Pro Ala Val Asn Ser Ile Thr Tyr Val Leu Arg
        435                 440                 445             
Phe Leu Glu Lys Leu Cys His Asn Leu Arg Ser Asp Asn Leu Phe Gly
    450                 455                 460                 
Asn Gln Pro Phe Thr Gln Thr His Leu Ser Leu Thr Ala Ile Glu Tyr
465                 470                 475                 480 
Ser His Ser His Asp Arg Tyr Leu Pro Gly Glu Thr Phe Val Leu Gly
                485                 490                 495     
Asn Ser Leu Ala Arg Ser Leu Glu Pro His Ser Asp Ser Met Asp Ser
            500                 505                 510         
Ala Ser Asn Pro Thr Asn Leu Val Ser Thr Ser Gln Arg His Arg Pro
        515                 520                 525             
Leu Leu Ser Ser Cys Gly Leu Pro Pro Ser Thr Ala Ser Ala Val Arg
    530                 535                 540                 
Arg Leu Cys Ser Arg Gly Val Leu Lys Gly Ser Asn Glu Arg Arg Asp
545                 550                 555                 560 
Met Glu Ser Phe Trp Lys Leu Asn Arg Ser Pro Gly Ser Asp Arg Tyr
                565                 570                 575     
Leu Glu Ser Arg Asp Ala Ser Arg Leu Ser Gly Arg Asp Pro Ser Ser
            580                 585                 590         
Trp Thr Val Glu Asp Val Met Gln Phe Val Arg Glu Ala Asp Pro Gln
        595                 600                 605             
Leu Gly Pro His Ala Asp Leu Phe Arg Lys His Glu Ile Asp Gly Lys
    610                 615                 620                 
Ala Leu Leu Leu Leu Arg Ser Asp Met Met Met Lys Tyr Met Gly Leu
625                 630                 635                 640 
Lys Leu Gly Pro Ala Leu Lys Leu Ser Tyr His Ile Asp Arg Leu Lys
                645                 650                 655     
Gln Gly Lys Phe
            660 


<210> 8932
<211> 616
<212> PRT
<213> Homo sapiens

<400> 8932
Asn Asn Ala Gly His Phe Thr Trp Asp Lys Tyr Leu Lys Glu Thr Cys
 1               5                  10                  15      
Ser Val Pro Ala Pro Val His Cys Phe Lys Gln Ser Tyr Thr Pro Pro
            20                  25                  30          
Ser Asn Glu Phe Lys Ile Ser Met Lys Leu Glu Ala Gln Asp Pro Arg
        35                  40                  45              
Asn Thr Thr Ser Thr Cys Ile Ala Thr Val Val Gly Leu Thr Gly Ala
    50                  55                  60                  
Arg Leu Arg Leu Arg Leu Asp Gly Ser Asp Asn Lys Asn Asp Phe Trp
65                  70                  75                  80  
Arg Leu Val Asp Ser Ala Glu Ile Gln Pro Ile Gly Asn Cys Glu Lys
                85                  90                  95      
Asn Gly Gly Met Leu Gln Pro Pro Leu Gly Phe Arg Leu Asn Ala Ser
            100                 105                 110         
Ser Trp Pro Met Phe Leu Leu Lys Thr Leu Asn Gly Ala Glu Met Ala
        115                 120                 125             
Pro Ile Arg Ile Phe His Lys Glu Pro Pro Ser Pro Ser His Asn Phe
    130                 135                 140                 
Phe Lys Met Gly Met Lys Leu Glu Ala Val Asp Arg Lys Asn Pro His
145                 150                 155                 160 
Phe Ile Cys Pro Ala Thr Ile Gly Glu Val Arg Gly Ser Glu Val Leu
                165                 170                 175     
Val Thr Phe Asp Gly Trp Arg Gly Ala Phe Asp Tyr Trp Cys Arg Phe
            180                 185                 190         
Asp Ser Arg Asp Ile Phe Pro Val Gly Trp Cys Ser Leu Thr Gly Asp
        195                 200                 205             
Asn Leu Gln Pro Pro Gly Thr Lys Val Val Ile Pro Lys Asn Pro Tyr
    210                 215                 220                 
Pro Ala Ser Asp Val Asn Thr Glu Lys Pro Ser Ile His Ser Ser Thr
225                 230                 235                 240 
Lys Thr Val Leu Glu His Gln Pro Gly Gln Arg Gly Arg Lys Pro Gly
                245                 250                 255     
Lys Lys Arg Gly Arg Thr Pro Lys Thr Leu Ile Ser His Pro Ile Ser
            260                 265                 270         
Ala Pro Ser Lys Thr Ala Glu Pro Leu Lys Phe Pro Lys Lys Arg Gly
        275                 280                 285             
Pro Lys Pro Gly Ser Lys Arg Lys Pro Arg Thr Leu Leu Asn Pro Pro
    290                 295                 300                 
Pro Ala Ser Pro Thr Thr Ser Thr Pro Glu Pro Asp Thr Ser Thr Val
305                 310                 315                 320 
Pro Gln Asp Ala Ala Thr Ile Pro Ser Ser Ala Met Gln Ala Pro Thr
                325                 330                 335     
Val Cys Ile Tyr Leu Asn Lys Asn Gly Ser Thr Gly Pro His Leu Asp
            340                 345                 350         
Lys Lys Lys Val Gln Gln Leu Pro Asp His Phe Gly Pro Ala Arg Ala
        355                 360                 365             
Ser Val Val Leu Gln Gln Ala Val Gln Ala Cys Ile Asp Cys Ala Tyr
    370                 375                 380                 
His Gln Lys Thr Val Phe Ser Phe Leu Lys Gln Gly His Gly Gly Glu
385                 390                 395                 400 
Val Ile Ser Ala Val Phe Asp Arg Glu Gln His Thr Leu Asn Leu Pro
                405                 410                 415     
Ala Val Asn Ser Ile Thr Tyr Val Leu Arg Phe Leu Glu Lys Leu Cys
            420                 425                 430         
His Asn Leu Arg Ser Asp Asn Leu Phe Gly Asn Gln Pro Phe Thr Gln
        435                 440                 445             
Thr His Leu Ser Leu Thr Ala Ile Glu Tyr Ser His Ser His Asp Arg
    450                 455                 460                 
Tyr Leu Pro Gly Glu Thr Phe Val Leu Gly Asn Ser Leu Ala Arg Ser
465                 470                 475                 480 
Leu Glu Pro His Ser Asp Ser Met Asp Ser Ala Ser Asn Pro Thr Asn
                485                 490                 495     
Leu Val Ser Thr Ser Gln Arg His Arg Pro Leu Leu Ser Ser Cys Gly
            500                 505                 510         
Leu Pro Pro Ser Thr Ala Ser Ala Val Arg Arg Leu Cys Ser Arg Gly
        515                 520                 525             
Ser Asp Arg Tyr Leu Glu Ser Arg Asp Ala Ser Arg Leu Ser Gly Arg
    530                 535                 540                 
Asp Pro Ser Ser Trp Thr Val Glu Asp Val Met Gln Phe Val Arg Glu
545                 550                 555                 560 
Ala Asp Pro Gln Leu Gly Pro His Ala Asp Leu Phe Arg Lys His Glu
                565                 570                 575     
Ile Asp Gly Lys Ala Leu Leu Leu Leu Arg Ser Asp Met Met Met Lys
            580                 585                 590         
Tyr Met Gly Leu Lys Leu Gly Pro Ala Leu Lys Leu Ser Tyr His Ile
        595                 600                 605             
Asp Arg Leu Lys Gln Gly Lys Phe
    610                 615     


<210> 8933
<211> 649
<212> PRT
<213> Homo sapiens

<400> 8933
Phe Ser Pro Ser Ala Val Ile Asp Trp Ser Asp Val Arg Lys His Lys
 1               5                  10                  15      
Tyr Gly His Leu Ser Glu Ser Ala Ser Gln Tyr Gln Glu Ala Ala Asp
            20                  25                  30          
Ile Leu Asp Leu Gly His Phe Thr Trp Asp Lys Tyr Leu Lys Glu Thr
        35                  40                  45              
Cys Ser Val Pro Ala Pro Val His Cys Phe Lys Gln Ser Tyr Thr Pro
    50                  55                  60                  
Pro Ser Asn Glu Phe Lys Ile Ser Met Lys Leu Glu Ala Gln Asp Pro
65                  70                  75                  80  
Arg Asn Thr Thr Ser Thr Cys Ile Ala Thr Val Val Gly Leu Thr Gly
                85                  90                  95      
Ala Arg Leu Arg Leu Arg Leu Asp Gly Ser Asp Asn Lys Asn Asp Phe
            100                 105                 110         
Trp Arg Leu Val Asp Ser Ala Glu Ile Gln Pro Ile Gly Asn Cys Glu
        115                 120                 125             
Lys Asn Gly Gly Met Leu Gln Pro Pro Leu Gly Phe Arg Leu Asn Ala
    130                 135                 140                 
Ser Ser Trp Pro Met Phe Leu Leu Lys Thr Leu Asn Gly Ala Glu Met
145                 150                 155                 160 
Ala Pro Ile Arg Ile Phe His Lys Glu Pro Pro Ser Pro Ser His Asn
                165                 170                 175     
Phe Phe Lys Met Gly Met Lys Leu Glu Ala Val Asp Arg Lys Asn Pro
            180                 185                 190         
His Phe Ile Cys Pro Ala Thr Ile Gly Glu Val Arg Gly Ser Glu Val
        195                 200                 205             
Leu Val Thr Phe Asp Gly Trp Arg Gly Ala Phe Asp Tyr Trp Cys Arg
    210                 215                 220                 
Phe Asp Ser Arg Asp Ile Phe Pro Val Gly Trp Cys Ser Leu Thr Gly
225                 230                 235                 240 
Asp Asn Leu Gln Pro Pro Gly Thr Lys Val Val Ile Pro Lys Asn Pro
                245                 250                 255     
Tyr Pro Ala Ser Asp Val Asn Thr Glu Lys Pro Ser Ile His Ser Ser
            260                 265                 270         
Thr Lys Thr Val Leu Glu His Gln Pro Gly Gln Arg Gly Arg Lys Pro
        275                 280                 285             
Gly Lys Lys Arg Gly Arg Thr Pro Lys Thr Leu Ile Ser His Pro Ile
    290                 295                 300                 
Ser Ala Pro Ser Lys Thr Ala Glu Pro Leu Lys Phe Pro Lys Lys Arg
305                 310                 315                 320 
Gly Pro Lys Pro Gly Ser Lys Arg Lys Pro Arg Thr Leu Leu Asn Pro
                325                 330                 335     
Pro Pro Ala Ser Pro Thr Thr Ser Thr Pro Glu Pro Asp Thr Ser Thr
            340                 345                 350         
Val Pro Gln Asp Ala Ala Thr Ile Pro Ser Ser Ala Met Gln Ala Pro
        355                 360                 365             
Thr Val Cys Ile Tyr Leu Asn Lys Asn Gly Ser Thr Gly Pro His Leu
    370                 375                 380                 
Asp Lys Lys Lys Val Gln Gln Leu Pro Asp His Phe Gly Pro Ala Arg
385                 390                 395                 400 
Ala Ser Val Val Leu Gln Gln Ala Val Gln Ala Cys Ile Asp Cys Ala
                405                 410                 415     
Tyr His Gln Lys Thr Val Phe Ser Phe Leu Lys Gln Gly His Gly Gly
            420                 425                 430         
Glu Val Ile Ser Ala Val Phe Asp Arg Glu Gln His Thr Leu Asn Leu
        435                 440                 445             
Pro Ala Val Asn Ser Ile Thr Tyr Val Leu Arg Phe Leu Glu Lys Leu
    450                 455                 460                 
Cys His Asn Leu Arg Ser Asp Asn Leu Phe Gly Asn Gln Pro Phe Thr
465                 470                 475                 480 
Gln Thr His Leu Ser Leu Thr Ala Ile Glu Tyr Ser His Ser His Asp
                485                 490                 495     
Arg Tyr Leu Pro Gly Glu Thr Phe Val Leu Gly Asn Ser Leu Ala Arg
            500                 505                 510         
Ser Leu Glu Pro His Ser Asp Ser Met Asp Ser Ala Ser Asn Pro Thr
        515                 520                 525             
Asn Leu Val Ser Thr Ser Gln Arg His Arg Pro Leu Leu Ser Ser Cys
    530                 535                 540                 
Gly Leu Pro Pro Ser Thr Ala Ser Ala Val Arg Arg Leu Cys Ser Arg
545                 550                 555                 560 
Gly Ser Asp Arg Tyr Leu Glu Ser Arg Asp Ala Ser Arg Leu Ser Gly
                565                 570                 575     
Arg Asp Pro Ser Ser Trp Thr Val Glu Asp Val Met Gln Phe Val Arg
            580                 585                 590         
Glu Ala Asp Pro Gln Leu Gly Pro His Ala Asp Leu Phe Arg Lys His
        595                 600                 605             
Glu Ile Asp Gly Lys Ala Leu Leu Leu Leu Arg Ser Asp Met Met Met
    610                 615                 620                 
Lys Tyr Met Gly Leu Lys Leu Gly Pro Ala Leu Lys Leu Ser Tyr His
625                 630                 635                 640 
Ile Asp Arg Leu Lys Gln Gly Lys Phe
                645                 


<210> 8934
<211> 1477
<212> PRT
<213> Homo sapiens

<400> 8934
Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu
 1               5                  10                  15      
Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu
            20                  25                  30          
Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala
        35                  40                  45              
Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg
    50                  55                  60                  
Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu
65                  70                  75                  80  
Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe
                85                  90                  95      
Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly
            100                 105                 110         
Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu
        115                 120                 125             
Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg
    130                 135                 140                 
Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro
145                 150                 155                 160 
Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu
                165                 170                 175     
Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser
            180                 185                 190         
Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro
        195                 200                 205             
Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu
    210                 215                 220                 
Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln
225                 230                 235                 240 
Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser
                245                 250                 255     
Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp
            260                 265                 270         
Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly
        275                 280                 285             
Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser
    290                 295                 300                 
Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu
305                 310                 315                 320 
Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys
                325                 330                 335     
Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu
            340                 345                 350         
Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His
        355                 360                 365             
Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly His
    370                 375                 380                 
Ala Met Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr
385                 390                 395                 400 
Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val
                405                 410                 415     
Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn
            420                 425                 430         
Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Val
        435                 440                 445             
Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro Lys Met Lys
    450                 455                 460                 
Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala Thr Leu Asp
465                 470                 475                 480 
Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu Pro Lys Trp
                485                 490                 495     
Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu
            500                 505                 510         
Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg His Gln Lys
        515                 520                 525             
Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe Ala Ile Glu
    530                 535                 540                 
Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr
545                 550                 555                 560 
Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly Glu Trp Tyr
                565                 570                 575     
His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn
            580                 585                 590         
Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu Ile Leu Asp
        595                 600                 605             
Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn Lys Ala Gly
    610                 615                 620                 
Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn Tyr Gly Tyr
625                 630                 635                 640 
Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser Lys Asp Ile
                645                 650                 655     
Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys Pro Ser Cys
            660                 665                 670         
Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys Lys Asn Asn
        675                 680                 685             
Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp Cys Ser Gly
    690                 695                 700                 
Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr Val Leu Ser
705                 710                 715                 720 
Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val Val Met His
                725                 730                 735     
Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln Arg Ala Tyr
            740                 745                 750         
Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg
        755                 760                 765             
Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn Leu Asp Cys
    770                 775                 780                 
Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr Leu Phe Ala
785                 790                 795                 800 
Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg
                805                 810                 815     
Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln Gln Ala Met Thr
            820                 825                 830         
Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe His Asn Ile Glu
        835                 840                 845             
Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser Val Pro Ser Asn
    850                 855                 860                 
Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly Met Ala Tyr Ile
865                 870                 875                 880 
Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu Asn Ala Arg
                885                 890                 895     
Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr Phe Lys Thr Lys
            900                 905                 910         
Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr Thr Ser Met His
        915                 920                 925             
Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly Leu Ile Leu Tyr
    930                 935                 940                 
Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu Leu Val Lys Gly
945                 950                 955                 960 
Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala Asn Leu Ile Lys
                965                 970                 975     
Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp His Asn Val Met
            980                 985                 990         
Ile Ser Arg Asp Thr Ser Asn Leu His Thr Val Lys Ile Asp Thr Lys
        995                 1000                1005            
Ile Thr Thr Gln Ile Thr Ala Gly Ala Arg Asn Leu Asp Leu Lys Ser
    1010                1015                1020                
Asp Leu Tyr Ile Gly Gly Val Ala Lys Glu Thr Tyr Lys Ser Leu Pro
1025                1030                1035                1040
Lys Leu Val His Ala Lys Glu Gly Phe Gln Gly Cys Leu Ala Ser Val
                1045                1050                1055    
Asp Leu Asn Gly Arg Leu Pro Asp Leu Ile Ser Asp Ala Leu Phe Cys
            1060                1065                1070        
Asn Gly Gln Ile Glu Arg Gly Cys Glu Gly Pro Ser Thr Thr Cys Gln
        1075                1080                1085            
Glu Asp Ser Cys Ser Asn Gln Gly Val Cys Leu Gln Gln Trp Asp Gly
    1090                1095                1100                
Phe Ser Cys Asp Cys Ser Met Thr Ser Phe Ser Gly Pro Leu Cys Asn
1105                1110                1115                1120
Asp Pro Gly Thr Thr Tyr Ile Phe Ser Lys Gly Gly Gly Gln Ile Thr
                1125                1130                1135    
Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr Arg Ala Asp Arg Leu
            1140                1145                1150        
Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala Val Leu Val Arg Val
        1155                1160                1165            
Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu Leu His Ile His Gln
    1170                1175                1180                
Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr Asp Asp Ile Ala Ile
1185                1190                1195                1200
Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys Tyr His Val Val Arg
                1205                1210                1215    
Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln Val Asp Ser Trp Pro
            1220                1225                1230        
Val Ile Glu Arg Tyr Pro Ala Gly Arg Gln Leu Thr Ile Phe Asn Ser
        1235                1240                1245            
Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln Gly Gln Pro Phe Gln
    1250                1255                1260                
Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu Lys Val Leu Asn Met
1265                1270                1275                1280
Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val Gly Asn Val Arg Leu
                1285                1290                1295    
Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu Ser Thr Ala Thr Ala
            1300                1305                1310        
Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu Thr Thr Thr Thr Leu
        1315                1320                1325            
Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro Thr Lys Glu Pro Ile
    1330                1335                1340                
Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser Ala Glu Cys Pro Ser
1345                1350                1355                1360
Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser Ser Gly Gly Leu Ala
                1365                1370                1375    
Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr Pro Gly Ser Ala Glu
            1380                1385                1390        
Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile Val
        1395                1400                1405            
Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys
    1410                1415                1420                
Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val Asp Glu Ser Arg Asn
1425                1430                1435                1440
Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala Val Val Lys Glu Lys
                1445                1450                1455    
Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn Lys Lys Asn Lys Asp
            1460                1465                1470        
Lys Glu Tyr Tyr Val
        1475        


<210> 8935
<211> 339
<212> PRT
<213> Homo sapiens

<400> 8935
Met Val Ser Lys Ser Arg Trp Lys Leu Leu Ala Met Leu Ala Leu Val
 1               5                  10                  15      
Leu Val Val Met Val Trp Tyr Ser Ile Ser Arg Glu Asp Arg Tyr Ile
            20                  25                  30          
Glu Leu Phe Tyr Phe Pro Ile Pro Glu Lys Lys Glu Pro Cys Leu Gln
        35                  40                  45              
Gly Glu Ala Glu Ser Lys Ala Ser Lys Leu Phe Gly Lys Leu Ser Pro
    50                  55                  60                  
Leu Cys Ser Tyr Ser Arg Asp Gln Pro Ile Phe Leu Arg Leu Glu Asp
65                  70                  75                  80  
Tyr Phe Trp Val Lys Thr Pro Ser Ala Tyr Glu Leu Pro Tyr Gly Thr
                85                  90                  95      
Lys Gly Ser Glu Asp Leu Leu Leu Arg Val Leu Ala Ile Thr Ser Ser
            100                 105                 110         
Ser Ile Pro Lys Asn Ile Gln Ser Leu Arg Cys Arg Arg Cys Val Val
        115                 120                 125             
Val Gly Asn Gly His Arg Leu Arg Asn Ser Ser Leu Gly Asp Ala Ile
    130                 135                 140                 
Asn Lys Tyr Asp Val Val Ile Arg Leu Asn Asn Ala Pro Val Ala Gly
145                 150                 155                 160 
Tyr Glu Gly Asp Val Gly Ser Lys Thr Thr Met Arg Leu Phe Tyr Pro
                165                 170                 175     
Glu Ser Ala His Phe Asp Pro Lys Val Glu Asn Asn Pro Asp Thr Leu
            180                 185                 190         
Leu Val Leu Val Ala Phe Lys Ala Met Asp Phe His Trp Ile Glu Thr
        195                 200                 205             
Ile Leu Ser Asp Lys Lys Arg Val Arg Lys Gly Phe Trp Lys Gln Pro
    210                 215                 220                 
Pro Leu Ile Trp Asp Val Asn Pro Lys Gln Ile Arg Ile Leu Asn Pro
225                 230                 235                 240 
Phe Phe Met Glu Ile Ala Ala Asp Lys Leu Leu Ser Leu Pro Met Gln
                245                 250                 255     
Gln Pro Arg Lys Ile Lys Gln Lys Pro Thr Thr Gly Leu Leu Ala Ile
            260                 265                 270         
Thr Leu Ala Leu His Leu Cys Asp Leu Val His Ile Ala Gly Phe Gly
        275                 280                 285             
Tyr Pro Asp Ala Tyr Asn Lys Lys Gln Thr Ile His Tyr Tyr Glu Gln
    290                 295                 300                 
Ile Thr Leu Lys Ser Met Ala Gly Ser Gly His Asn Val Ser Gln Glu
305                 310                 315                 320 
Ala Leu Ala Ile Lys Arg Met Leu Glu Met Gly Ala Ile Lys Asn Leu
                325                 330                 335     
Thr Ser Phe
            


<210> 8936
<211> 332
<212> PRT
<213> Homo sapiens

<400> 8936
Met Cys Pro Ala Gly Trp Lys Leu Leu Ala Met Leu Ala Leu Val Leu
 1               5                  10                  15      
Val Val Met Val Trp Tyr Ser Ile Ser Arg Glu Asp Arg Tyr Ile Glu
            20                  25                  30          
Leu Phe Tyr Phe Pro Ile Pro Glu Lys Lys Glu Pro Cys Leu Gln Gly
        35                  40                  45              
Glu Ala Glu Ser Lys Ala Ser Lys Leu Phe Gly Asn Tyr Ser Arg Asp
    50                  55                  60                  
Gln Pro Ile Phe Leu Arg Leu Glu Asp Tyr Phe Trp Val Lys Thr Pro
65                  70                  75                  80  
Ser Ala Tyr Glu Leu Pro Tyr Gly Thr Lys Gly Ser Glu Asp Leu Leu
                85                  90                  95      
Leu Arg Val Leu Ala Ile Thr Ser Ser Ser Ile Pro Lys Asn Ile Gln
            100                 105                 110         
Ser Leu Arg Cys Arg Arg Cys Val Val Val Gly Asn Gly His Arg Leu
        115                 120                 125             
Arg Asn Ser Ser Leu Gly Asp Ala Ile Asn Lys Tyr Asp Val Val Ile
    130                 135                 140                 
Arg Leu Asn Asn Ala Pro Val Ala Gly Tyr Glu Gly Asp Val Gly Ser
145                 150                 155                 160 
Lys Thr Thr Met Arg Leu Phe Tyr Pro Glu Ser Ala His Phe Asp Pro
                165                 170                 175     
Lys Val Glu Asn Asn Pro Asp Thr Leu Leu Val Leu Val Ala Phe Lys
            180                 185                 190         
Ala Met Asp Phe His Trp Ile Glu Thr Ile Leu Ser Asp Lys Lys Arg
        195                 200                 205             
Val Arg Lys Gly Phe Trp Lys Gln Pro Pro Leu Ile Trp Asp Val Asn
    210                 215                 220                 
Pro Lys Gln Ile Arg Ile Leu Asn Pro Phe Phe Met Glu Ile Ala Ala
225                 230                 235                 240 
Asp Lys Leu Leu Ser Leu Pro Met Gln Gln Pro Arg Lys Ile Lys Gln
                245                 250                 255     
Lys Pro Thr Thr Gly Leu Leu Ala Ile Thr Leu Ala Leu His Leu Cys
            260                 265                 270         
Asp Leu Val His Ile Ala Gly Phe Gly Tyr Pro Asp Ala Tyr Asn Lys
        275                 280                 285             
Lys Gln Thr Ile His Tyr Tyr Glu Gln Ile Thr Leu Lys Ser Met Ala
    290                 295                 300                 
Gly Ser Gly His Asn Val Ser Gln Glu Ala Leu Ala Ile Lys Arg Met
305                 310                 315                 320 
Leu Glu Met Gly Ala Ile Lys Asn Leu Thr Ser Phe
                325                 330         


<210> 8937
<211> 333
<212> PRT
<213> Homo sapiens

<400> 8937
Met Val Ser Lys Ser Arg Trp Lys Leu Leu Ala Met Leu Ala Leu Val
 1               5                  10                  15      
Leu Val Val Met Val Trp Tyr Ser Ile Ser Arg Glu Asp Arg Tyr Ile
            20                  25                  30          
Glu Leu Phe Tyr Phe Pro Ile Pro Glu Lys Lys Glu Pro Cys Leu Gln
        35                  40                  45              
Gly Glu Ala Glu Ser Lys Ala Ser Lys Leu Phe Gly Asn Tyr Ser Arg
    50                  55                  60                  
Asp Gln Pro Ile Phe Leu Arg Leu Glu Asp Tyr Phe Trp Val Lys Thr
65                  70                  75                  80  
Pro Ser Ala Tyr Glu Leu Pro Tyr Gly Thr Lys Gly Ser Glu Asp Leu
                85                  90                  95      
Leu Leu Arg Val Leu Ala Ile Thr Ser Ser Ser Ile Pro Lys Asn Ile
            100                 105                 110         
Gln Ser Leu Arg Cys Arg Arg Cys Val Val Val Gly Asn Gly His Arg
        115                 120                 125             
Leu Arg Asn Ser Ser Leu Gly Asp Ala Ile Asn Lys Tyr Asp Val Val
    130                 135                 140                 
Ile Arg Leu Asn Asn Ala Pro Val Ala Gly Tyr Glu Gly Asp Val Gly
145                 150                 155                 160 
Ser Lys Thr Thr Met Arg Leu Phe Tyr Pro Glu Ser Ala His Phe Asp
                165                 170                 175     
Pro Lys Val Glu Asn Asn Pro Asp Thr Leu Leu Val Leu Val Ala Phe
            180                 185                 190         
Lys Ala Met Asp Phe His Trp Ile Glu Thr Ile Leu Ser Asp Lys Lys
        195                 200                 205             
Arg Val Arg Lys Gly Phe Trp Lys Gln Pro Pro Leu Ile Trp Asp Val
    210                 215                 220                 
Asn Pro Lys Gln Ile Arg Ile Leu Asn Pro Phe Phe Met Glu Ile Ala
225                 230                 235                 240 
Ala Asp Lys Leu Leu Ser Leu Pro Met Gln Gln Pro Arg Lys Ile Lys
                245                 250                 255     
Gln Lys Pro Thr Thr Gly Leu Leu Ala Ile Thr Leu Ala Leu His Leu
            260                 265                 270         
Cys Asp Leu Val His Ile Ala Gly Phe Gly Tyr Pro Asp Ala Tyr Asn
        275                 280                 285             
Lys Lys Gln Thr Ile His Tyr Tyr Glu Gln Ile Thr Leu Lys Ser Met
    290                 295                 300                 
Ala Gly Ser Gly His Asn Val Ser Gln Glu Ala Leu Ala Ile Lys Arg
305                 310                 315                 320 
Met Leu Glu Met Gly Ala Ile Lys Asn Leu Thr Ser Phe
                325                 330             


<210> 8938
<211> 322
<212> PRT
<213> Homo sapiens

<400> 8938
Met Leu Ala Leu Val Leu Val Val Met Val Trp Tyr Ser Ile Ser Arg
 1               5                  10                  15      
Glu Asp Arg Tyr Ile Glu Leu Phe Tyr Phe Pro Ile Pro Glu Lys Lys
            20                  25                  30          
Glu Pro Cys Leu Gln Gly Glu Ala Glu Ser Lys Ala Ser Lys Leu Phe
        35                  40                  45              
Gly Asn Tyr Ser Arg Asp Gln Pro Ile Phe Leu Arg Leu Glu Asp Tyr
    50                  55                  60                  
Phe Trp Val Lys Thr Pro Ser Ala Tyr Glu Leu Pro Tyr Gly Thr Lys
65                  70                  75                  80  
Gly Ser Glu Asp Leu Leu Leu Arg Val Leu Ala Ile Thr Ser Ser Ser
                85                  90                  95      
Ile Pro Lys Asn Ile Gln Ser Leu Arg Cys Arg Arg Cys Val Val Val
            100                 105                 110         
Gly Asn Gly His Arg Leu Arg Asn Ser Ser Leu Gly Asp Ala Ile Asn
        115                 120                 125             
Lys Tyr Asp Val Val Ile Arg Leu Asn Asn Ala Pro Val Ala Gly Tyr
    130                 135                 140                 
Glu Gly Asp Val Gly Ser Lys Thr Thr Met Arg Leu Phe Tyr Pro Glu
145                 150                 155                 160 
Ser Ala His Phe Asp Pro Lys Val Glu Asn Asn Pro Asp Thr Leu Leu
                165                 170                 175     
Val Leu Val Ala Phe Lys Ala Met Asp Phe His Trp Ile Glu Thr Ile
            180                 185                 190         
Leu Ser Asp Lys Lys Arg Val Arg Lys Gly Phe Trp Lys Gln Pro Pro
        195                 200                 205             
Leu Ile Trp Asp Val Asn Pro Lys Gln Ile Arg Ile Leu Asn Pro Phe
    210                 215                 220                 
Phe Met Glu Ile Ala Ala Asp Lys Leu Leu Ser Leu Pro Met Gln Gln
225                 230                 235                 240 
Pro Arg Lys Ile Lys Gln Lys Pro Thr Thr Gly Leu Leu Ala Ile Thr
                245                 250                 255     
Leu Ala Leu His Leu Cys Asp Leu Val His Ile Ala Gly Phe Gly Tyr
            260                 265                 270         
Pro Asp Ala Tyr Asn Lys Lys Gln Thr Ile His Tyr Tyr Glu Gln Ile
        275                 280                 285             
Thr Leu Lys Ser Met Ala Gly Ser Gly His Asn Val Ser Gln Glu Ala
    290                 295                 300                 
Leu Ala Ile Lys Arg Met Leu Glu Met Gly Ala Ile Lys Asn Leu Thr
305                 310                 315                 320 
Ser Phe
        


<210> 8939
<211> 489
<212> PRT
<213> Homo sapiens

<400> 8939
Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His
 1               5                  10                  15      
Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser
            20                  25                  30          
Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His
        35                  40                  45              
Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met
    50                  55                  60                  
Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr
65                  70                  75                  80  
Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys
                85                  90                  95      
Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys
            100                 105                 110         
Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp
        115                 120                 125             
Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val
    130                 135                 140                 
Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile
145                 150                 155                 160 
Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr
                165                 170                 175     
Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly
            180                 185                 190         
Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr
        195                 200                 205             
Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe
    210                 215                 220                 
Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met
225                 230                 235                 240 
Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp
                245                 250                 255     
Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp
            260                 265                 270         
Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu
        275                 280                 285             
Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys
    290                 295                 300                 
Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu
305                 310                 315                 320 
Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala
                325                 330                 335     
Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg
            340                 345                 350         
Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys
        355                 360                 365             
Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala
    370                 375                 380                 
Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn
385                 390                 395                 400 
Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr
                405                 410                 415     
Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp
            420                 425                 430         
Ala Val Tyr Glu Lys Asn Gly Ser His Ser Val Thr Gln Ala Gly Val
        435                 440                 445             
His Cys Arg Asn Leu Ser Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys
    450                 455                 460                 
Arg Phe Ser Cys Leu Ser Leu Trp Ser Ser Trp Asp Tyr Arg Leu Tyr
465                 470                 475                 480 
Leu Phe Phe Gln Arg Thr His Thr Val
                485                 


<210> 8940
<211> 1067
<212> PRT
<213> Homo sapiens

<400> 8940
Met Asn Ser Met Asp Arg His Ile Gln Gln Thr Asn Asp Arg Leu Gln
 1               5                  10                  15      
Cys Ile Lys Gln His Leu Gln Asn Pro Ala Asn Phe His Asn Ala Ala
            20                  25                  30          
Thr Glu Leu Leu Asp Trp Cys Gly Asp Pro Arg Ala Phe Gln Arg Pro
        35                  40                  45              
Phe Glu Gln Ser Leu Met Gly Cys Leu Thr Val Val Ser Arg Val Ala
    50                  55                  60                  
Ala Gln Gln Gly Phe Asp Leu Asp Leu Gly Tyr Arg Leu Leu Ala Val
65                  70                  75                  80  
Cys Ala Ala Asn Arg Asp Lys Phe Thr Pro Lys Ser Ala Ala Leu Leu
                85                  90                  95      
Ser Ser Trp Cys Glu Glu Leu Gly Arg Leu Leu Leu Leu Arg His Gln
            100                 105                 110         
Lys Ser Arg Gln Ser Asp Pro Pro Gly Lys Leu Pro Met Gln Pro Pro
        115                 120                 125             
Leu Ser Ser Met Ser Ser Met Lys Pro Thr Leu Ser His Ser Asp Gly
    130                 135                 140                 
Ser Phe Pro Tyr Asp Ser Val Pro Trp Gln Gln Asn Thr Asn Gln Pro
145                 150                 155                 160 
Pro Gly Ser Leu Ser Val Val Thr Thr Val Trp Gly Val Thr Asn Thr
                165                 170                 175     
Ser Gln Ser Gln Val Leu Gly Asn Pro Met Ala Asn Ala Asn Asn Pro
            180                 185                 190         
Met Asn Pro Gly Gly Asn Pro Met Ala Ser Gly Met Thr Thr Ser Asn
        195                 200                 205             
Pro Gly Leu Asn Ser Pro Gln Phe Ala Gly Gln Gln Gln Gln Phe Ser
    210                 215                 220                 
Ala Lys Ala Gly Pro Ala Gln Pro Tyr Ile Gln Gln Ser Met Tyr Gly
225                 230                 235                 240 
Arg Pro Asn Tyr Pro Gly Ser Gly Gly Phe Gly Ala Ser Tyr Pro Gly
                245                 250                 255     
Gly Pro Asn Ala Pro Ala Gly Met Gly Ile Pro Pro His Thr Arg Pro
            260                 265                 270         
Pro Ala Asp Phe Thr Gln Pro Ala Ala Ala Ala Ala Ala Ala Ala Val
        275                 280                 285             
Ala Ala Ala Ala Ala Thr Ala Thr Ala Thr Ala Thr Ala Thr Val Ala
    290                 295                 300                 
Ala Leu Gln Glu Thr Gln Asn Lys Asp Ile Asn Gln Tyr Gly Pro Met
305                 310                 315                 320 
Gly Pro Thr Gln Ala Tyr Asn Ser Gln Phe Met Asn Gln Pro Gly Pro
                325                 330                 335     
Arg Gly Pro Ala Ser Met Gly Gly Ser Met Asn Pro Ala Ser Met Ala
            340                 345                 350         
Ala Gly Met Thr Pro Ser Gly Met Ser Gly Pro Pro Met Gly Met Asn
        355                 360                 365             
Gln Pro Arg Pro Pro Gly Ile Ser Pro Phe Gly Thr His Gly Gln Arg
    370                 375                 380                 
Met Pro Gln Gln Thr Tyr Pro Gly Pro Arg Pro Gln Ser Leu Pro Ile
385                 390                 395                 400 
Gln Asn Ile Lys Arg Pro Tyr Pro Gly Glu Pro Asn Tyr Gly Asn Gln
                405                 410                 415     
Gln Tyr Gly Pro Asn Ser Gln Phe Pro Thr Gln Pro Gly Gln Tyr Pro
            420                 425                 430         
Ala Pro Asn Pro Pro Arg Pro Leu Thr Ser Pro Asn Tyr Pro Gly Gln
        435                 440                 445             
Arg Met Pro Ser Gln Pro Ser Ser Gly Gln Tyr Pro Pro Pro Thr Val
    450                 455                 460                 
Asn Met Gly Gln Tyr Tyr Lys Pro Glu Gln Phe Asn Gly Gln Asn Asn
465                 470                 475                 480 
Thr Phe Ser Gly Ser Ser Tyr Ser Asn Tyr Ser Gln Gly Asn Val Asn
                485                 490                 495     
Arg Pro Pro Arg Pro Val Pro Val Ala Asn Tyr Pro His Ser Pro Val
            500                 505                 510         
Pro Gly Asn Pro Thr Pro Pro Met Thr Pro Gly Ser Ser Ile Pro Pro
        515                 520                 525             
Tyr Leu Ser Pro Ser Gln Asp Val Lys Pro Pro Phe Pro Pro Asp Ile
    530                 535                 540                 
Lys Pro Asn Met Ser Ala Leu Pro Pro Pro Pro Ala Asn His Asn Asp
545                 550                 555                 560 
Glu Leu Arg Leu Thr Phe Pro Val Arg Asp Gly Val Val Leu Glu Pro
                565                 570                 575     
Phe Arg Leu Glu His Asn Leu Ala Val Ser Asn His Val Phe His Leu
            580                 585                 590         
Arg Pro Thr Val His Gln Thr Leu Met Trp Arg Ser Asp Leu Glu Leu
        595                 600                 605             
Gln Phe Lys Cys Tyr His His Glu Asp Arg Gln Met Asn Thr Asn Trp
    610                 615                 620                 
Pro Ala Ser Val Gln Val Ser Val Asn Ala Thr Pro Leu Thr Ile Glu
625                 630                 635                 640 
Arg Gly Asp Asn Lys Thr Ser His Lys Pro Leu His Leu Lys His Val
                645                 650                 655     
Cys Gln Pro Gly Arg Asn Thr Ile Gln Ile Thr Val Thr Ala Cys Cys
            660                 665                 670         
Cys Ser His Leu Phe Val Leu Gln Leu Val His Arg Pro Ser Val Arg
        675                 680                 685             
Ser Val Leu Gln Gly Leu Leu Lys Lys Arg Leu Leu Pro Ala Glu His
    690                 695                 700                 
Cys Ile Thr Lys Ile Lys Arg Asn Phe Ser Ser Val Ala Ala Ser Ser
705                 710                 715                 720 
Gly Asn Thr Thr Leu Asn Gly Glu Asp Gly Val Glu Gln Thr Ala Ile
                725                 730                 735     
Lys Val Ser Leu Lys Cys Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro
            740                 745                 750         
Ala Arg Gly His Asp Cys Lys His Val Gln Cys Phe Asp Leu Glu Ser
        755                 760                 765             
Tyr Leu Gln Leu Asn Cys Glu Arg Gly Thr Trp Arg Cys Pro Val Cys
    770                 775                 780                 
Asn Lys Thr Ala Leu Leu Glu Gly Leu Glu Val Asp Gln Tyr Met Trp
785                 790                 795                 800 
Gly Ile Leu Asn Ala Ile Gln His Ser Glu Phe Glu Glu Val Thr Ile
                805                 810                 815     
Asp Pro Thr Cys Ser Trp Arg Pro Val Pro Ile Lys Ser Asp Leu His
            820                 825                 830         
Ile Lys Asp Asp Pro Asp Gly Ile Pro Ser Lys Arg Phe Lys Thr Met
        835                 840                 845             
Ser Pro Ser Gln Met Ile Met Pro Asn Val Met Glu Met Ile Ala Ala
    850                 855                 860                 
Leu Gly Pro Gly Pro Ser Pro Tyr Pro Leu Pro Pro Pro Pro Gly Gly
865                 870                 875                 880 
Thr Asn Ser Asn Asp Tyr Ser Ser Gln Gly Asn Asn Tyr Gln Gly His
                885                 890                 895     
Gly Asn Phe Asp Phe Pro His Gly Asn Pro Gly Gly Thr Ser Met Asn
            900                 905                 910         
Asp Phe Met His Gly Pro Pro Gln Leu Ser His Pro Pro Asp Met Pro
        915                 920                 925             
Asn Asn Met Ala Ala Leu Glu Lys Pro Leu Ser His Pro Met Gln Glu
    930                 935                 940                 
Thr Met Pro His Ala Gly Ser Ser Asp Gln Pro His Pro Ser Ile Gln
945                 950                 955                 960 
Gln Gly Leu His Val Pro His Pro Ser Ser Gln Ser Gly Pro Pro Leu
                965                 970                 975     
His His Ser Gly Ala Pro Pro Pro Pro Pro Ser Gln Pro Pro Arg Gln
            980                 985                 990         
Pro Pro Gln Ala Ala Pro Ser Ser His Pro His Ser Asp Leu Thr Phe
        995                 1000                1005            
Asn Pro Ser Ser Ala Leu Glu Gly Gln Ala Gly Ala Gln Gly Ala Ser
    1010                1015                1020                
Asp Met Pro Glu Pro Ser Leu Asp Leu Leu Pro Glu Leu Thr Asn Pro
1025                1030                1035                1040
Asp Glu Leu Leu Ser Tyr Leu Asp Pro Pro Asp Leu Pro Ser Asn Ser
                1045                1050                1055    
Asn Asp Asp Leu Leu Ser Leu Phe Glu Asn Asn
            1060                1065        


<210> 8941
<211> 997
<212> PRT
<213> Homo sapiens

<400> 8941
Arg Pro Pro Pro Ala Gly Pro Gln Ala Pro Glu Gly Ala Arg Ala Gly
 1               5                  10                  15      
Ser Arg Pro Val Gln Leu Leu Ala Leu Leu Ser Ser Trp Cys Glu Glu
            20                  25                  30          
Leu Gly Arg Leu Leu Leu Leu Arg His Gln Lys Ser Arg Gln Ser Asp
        35                  40                  45              
Pro Pro Gly Lys Leu Pro Met Gln Pro Pro Leu Ser Ser Met Ser Ser
    50                  55                  60                  
Met Lys Pro Thr Leu Ser His Ser Asp Gly Ser Phe Pro Tyr Asp Ser
65                  70                  75                  80  
Val Pro Trp Gln Gln Asn Thr Asn Gln Pro Pro Gly Ser Leu Ser Val
                85                  90                  95      
Val Thr Thr Val Trp Gly Val Thr Asn Thr Ser Gln Ser Gln Val Leu
            100                 105                 110         
Gly Asn Pro Met Ala Asn Ala Asn Asn Pro Met Asn Pro Gly Gly Asn
        115                 120                 125             
Pro Met Ala Ser Gly Met Thr Thr Ser Asn Pro Gly Leu Asn Ser Pro
    130                 135                 140                 
Gln Phe Ala Gly Gln Gln Gln Gln Phe Ser Ala Lys Ala Gly Pro Ala
145                 150                 155                 160 
Gln Pro Tyr Ile Gln Gln Ser Met Tyr Gly Arg Pro Asn Tyr Pro Gly
                165                 170                 175     
Ser Gly Gly Phe Gly Ala Ser Tyr Pro Gly Gly Pro Asn Ala Pro Ala
            180                 185                 190         
Gly Met Gly Ile Pro Pro His Thr Arg Pro Pro Ala Asp Phe Thr Gln
        195                 200                 205             
Pro Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Thr
    210                 215                 220                 
Ala Thr Ala Thr Ala Thr Ala Thr Val Ala Ala Leu Gln Glu Thr Gln
225                 230                 235                 240 
Asn Lys Asp Ile Asn Gln Tyr Gly Pro Met Gly Pro Thr Gln Ala Tyr
                245                 250                 255     
Asn Ser Gln Phe Met Asn Gln Pro Gly Pro Arg Gly Pro Ala Ser Met
            260                 265                 270         
Gly Gly Ser Met Asn Pro Ala Ser Met Ala Ala Gly Met Thr Pro Ser
        275                 280                 285             
Gly Met Ser Gly Pro Pro Met Gly Met Asn Gln Pro Arg Pro Pro Gly
    290                 295                 300                 
Ile Ser Pro Phe Gly Thr His Gly Gln Arg Met Pro Gln Gln Thr Tyr
305                 310                 315                 320 
Pro Gly Pro Arg Pro Gln Ser Leu Pro Ile Gln Asn Ile Lys Arg Pro
                325                 330                 335     
Tyr Pro Gly Glu Pro Asn Tyr Gly Asn Gln Gln Tyr Gly Pro Asn Ser
            340                 345                 350         
Gln Phe Pro Thr Gln Pro Gly Gln Tyr Pro Ala Pro Asn Pro Pro Arg
        355                 360                 365             
Pro Leu Thr Ser Pro Asn Tyr Pro Gly Gln Arg Met Pro Ser Gln Pro
    370                 375                 380                 
Ser Ser Gly Gln Tyr Pro Pro Pro Thr Val Asn Met Gly Gln Tyr Tyr
385                 390                 395                 400 
Lys Pro Glu Gln Phe Asn Gly Gln Asn Asn Thr Phe Ser Gly Ser Ser
                405                 410                 415     
Tyr Ser Asn Tyr Ser Gln Gly Asn Val Asn Arg Pro Pro Arg Pro Val
            420                 425                 430         
Pro Val Ala Asn Tyr Pro His Ser Pro Val Pro Gly Asn Pro Thr Pro
        435                 440                 445             
Pro Met Thr Pro Gly Ser Ser Ile Pro Pro Tyr Leu Ser Pro Ser Gln
    450                 455                 460                 
Asp Val Lys Pro Pro Phe Pro Pro Asp Ile Lys Pro Asn Met Ser Ala
465                 470                 475                 480 
Leu Pro Pro Pro Pro Ala Asn His Asn Asp Glu Leu Arg Leu Thr Phe
                485                 490                 495     
Pro Val Arg Asp Gly Val Val Leu Glu Pro Phe Arg Leu Glu His Asn
            500                 505                 510         
Leu Ala Val Ser Asn His Val Phe His Leu Arg Pro Thr Val His Gln
        515                 520                 525             
Thr Leu Met Trp Arg Ser Asp Leu Glu Leu Gln Phe Lys Cys Tyr His
    530                 535                 540                 
His Glu Asp Arg Gln Met Asn Thr Asn Trp Pro Ala Ser Val Gln Val
545                 550                 555                 560 
Ser Val Asn Ala Thr Pro Leu Thr Ile Glu Arg Gly Asp Asn Lys Thr
                565                 570                 575     
Ser His Lys Pro Leu His Leu Lys His Val Cys Gln Pro Gly Arg Asn
            580                 585                 590         
Thr Ile Gln Ile Thr Val Thr Ala Cys Cys Cys Ser His Leu Phe Val
        595                 600                 605             
Leu Gln Leu Val His Arg Pro Ser Val Arg Ser Val Leu Gln Gly Leu
    610                 615                 620                 
Leu Lys Lys Arg Leu Leu Pro Ala Glu His Cys Ile Thr Lys Ile Lys
625                 630                 635                 640 
Arg Asn Phe Ser Ser Val Ala Ala Ser Ser Gly Asn Thr Thr Leu Asn
                645                 650                 655     
Gly Glu Asp Gly Val Glu Gln Thr Ala Ile Lys Val Ser Leu Lys Cys
            660                 665                 670         
Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro Ala Arg Gly His Asp Cys
        675                 680                 685             
Lys His Val Gln Cys Phe Asp Leu Glu Ser Tyr Leu Gln Leu Asn Cys
    690                 695                 700                 
Glu Arg Gly Thr Trp Arg Cys Pro Val Cys Asn Lys Thr Ala Leu Leu
705                 710                 715                 720 
Glu Gly Leu Glu Val Asp Gln Tyr Met Trp Gly Ile Leu Asn Ala Ile
                725                 730                 735     
Gln His Ser Glu Phe Glu Glu Val Thr Ile Asp Pro Thr Cys Ser Trp
            740                 745                 750         
Arg Pro Val Pro Ile Lys Ser Asp Leu His Ile Lys Asp Asp Pro Asp
        755                 760                 765             
Gly Ile Pro Ser Lys Arg Phe Lys Thr Met Ser Pro Ser Gln Met Ile
    770                 775                 780                 
Met Pro Asn Val Met Glu Met Ile Ala Ala Leu Gly Pro Gly Pro Ser
785                 790                 795                 800 
Pro Tyr Pro Leu Pro Pro Pro Pro Gly Gly Thr Asn Ser Asn Asp Tyr
                805                 810                 815     
Ser Ser Gln Gly Asn Asn Tyr Gln Gly His Gly Asn Phe Asp Phe Pro
            820                 825                 830         
His Gly Asn Pro Gly Gly Thr Ser Met Asn Asp Phe Met His Gly Pro
        835                 840                 845             
Pro Gln Leu Ser His Pro Pro Asp Met Pro Asn Asn Met Ala Ala Leu
    850                 855                 860                 
Glu Lys Pro Leu Ser His Pro Met Gln Glu Thr Met Pro His Ala Gly
865                 870                 875                 880 
Ser Ser Asp Gln Pro His Pro Ser Ile Gln Gln Gly Leu His Val Pro
                885                 890                 895     
His Pro Ser Ser Gln Ser Gly Pro Pro Leu His His Ser Gly Ala Pro
            900                 905                 910         
Pro Pro Pro Pro Ser Gln Pro Pro Arg Gln Pro Pro Gln Ala Ala Pro
        915                 920                 925             
Ser Ser His Pro His Ser Asp Leu Thr Phe Asn Pro Ser Ser Ala Leu
    930                 935                 940                 
Glu Gly Gln Ala Gly Ala Gln Gly Ala Ser Asp Met Pro Glu Pro Ser
945                 950                 955                 960 
Leu Asp Leu Leu Pro Glu Leu Thr Asn Pro Asp Glu Leu Leu Ser Tyr
                965                 970                 975     
Leu Asp Pro Pro Asp Leu Pro Ser Asn Ser Asn Asp Asp Leu Leu Ser
            980                 985                 990         
Leu Phe Glu Asn Asn
        995         


<210> 8942
<211> 1297
<212> PRT
<213> Homo sapiens

<400> 8942
Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp
 1               5                  10                  15      
Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu
            20                  25                  30          
Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu
        35                  40                  45              
Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala
    50                  55                  60                  
Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala
65                  70                  75                  80  
Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe
                85                  90                  95      
Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val
            100                 105                 110         
Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro
        115                 120                 125             
Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro
    130                 135                 140                 
Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln
145                 150                 155                 160 
Asp Pro Arg Thr Pro Gly Gly Ser Glu Trp Arg Glu Thr Gly Pro Gln
                165                 170                 175     
Phe Arg Cys Leu Pro Pro Val Pro Ala Asp Met Val Phe Leu Val Asp
            180                 185                 190         
Gly Ser Trp Ser Ile Gly His Ser His Phe Gln Gln Val Lys Asp Phe
        195                 200                 205             
Leu Ala Ser Val Ile Ala Pro Phe Glu Ile Gly Pro Asp Lys Val Gln
    210                 215                 220                 
Val Gly Leu Thr Gln Tyr Ser Gly Asp Ala Gln Thr Glu Trp Asp Leu
225                 230                 235                 240 
Asn Ser Leu Ser Thr Lys Glu Gln Val Leu Ala Ala Val Arg Arg Leu
                245                 250                 255     
Arg Tyr Lys Gly Gly Asn Thr Phe Thr Gly Leu Ala Leu Thr His Val
            260                 265                 270         
Leu Gly Gln Asn Leu Gln Pro Ala Ala Gly Leu Arg Pro Glu Ala Ala
        275                 280                 285             
Lys Val Val Ile Leu Val Thr Asp Gly Lys Ser Gln Asp Asp Val His
    290                 295                 300                 
Thr Ala Ala Arg Val Leu Lys Asp Leu Gly Val Asn Val Phe Ala Val
305                 310                 315                 320 
Gly Val Lys Asn Ala Asp Glu Ala Glu Leu Arg Leu Leu Ala Ser Pro
                325                 330                 335     
Pro Arg Asp Ile Thr Val His Ser Val Leu Asp Phe Leu Gln Leu Gly
            340                 345                 350         
Ala Leu Ala Gly Leu Leu Ser Arg Leu Ile Cys Gln Arg Leu Gln Gly
        355                 360                 365             
Gly Ser Pro Arg Gln Gly Pro Ala Ala Ala Pro Ala Leu Asp Thr Leu
    370                 375                 380                 
Pro Ala Pro Thr Ser Leu Val Leu Ser Gln Val Thr Ser Ser Ser Ile
385                 390                 395                 400 
Arg Leu Ser Trp Thr Pro Ala Pro Arg His Pro Leu Lys Tyr Leu Ile
                405                 410                 415     
Val Trp Arg Ala Ser Arg Gly Gly Thr Pro Arg Glu Val Val Val Glu
            420                 425                 430         
Gly Pro Ala Ala Ser Thr Glu Leu His Asn Leu Ala Ser Arg Thr Glu
        435                 440                 445             
Tyr Leu Val Ser Val Phe Pro Ile Tyr Glu Gly Gly Val Gly Glu Gly
    450                 455                 460                 
Leu Arg Gly Leu Val Thr Thr Ala Pro Leu Pro Pro Pro Arg Ala Leu
465                 470                 475                 480 
Thr Leu Ala Ala Val Thr Pro Arg Thr Val His Leu Thr Trp Gln Pro
                485                 490                 495     
Ser Ala Gly Ala Thr His Tyr Leu Val Arg Cys Ser Pro Ala Ser Pro
            500                 505                 510         
Lys Gly Glu Glu Glu Glu Arg Glu Val Gln Val Gly Arg Pro Glu Val
        515                 520                 525             
Leu Leu Asp Gly Leu Glu Pro Gly Arg Asp Tyr Glu Val Ser Val Gln
    530                 535                 540                 
Ser Leu Arg Gly Pro Glu Gly Ser Glu Ala Arg Gly Ile Arg Ala Arg
545                 550                 555                 560 
Thr Pro Thr Leu Ala Pro Pro Arg His Leu Gly Phe Ser Asp Val Ser
                565                 570                 575     
His Asp Ala Ala Arg Val Phe Trp Glu Gly Ala Pro Arg Pro Val Arg
            580                 585                 590         
Leu Val Arg Val Thr Tyr Val Ser Ser Glu Gly Gly His Ser Gly Gln
        595                 600                 605             
Thr Glu Ala Pro Gly Asn Ala Thr Ser Ala Met Leu Gly Pro Leu Ser
    610                 615                 620                 
Ser Ser Thr Thr Tyr Thr Val Arg Val Thr Cys Leu Tyr Pro Gly Gly
625                 630                 635                 640 
Gly Ser Ser Thr Leu Thr Gly Arg Val Thr Thr Lys Lys Ala Pro Ser
                645                 650                 655     
Pro Ser Gln Leu Ser Met Thr Glu Leu Pro Gly Asp Ala Val Gln Leu
            660                 665                 670         
Ala Trp Val Ala Ala Ala Pro Ser Gly Val Leu Val Tyr Gln Ile Thr
        675                 680                 685             
Trp Thr Pro Leu Gly Glu Gly Lys Ala His Glu Ile Ser Val Pro Gly
    690                 695                 700                 
Asn Leu Gly Thr Ala Val Leu Pro Gly Leu Gly Arg His Thr Glu Tyr
705                 710                 715                 720 
Asp Val Thr Ile Leu Ala Tyr Tyr Arg Asp Gly Ala Arg Ser Asp Pro
                725                 730                 735     
Val Ser Leu Arg Tyr Thr Pro Ser Thr Val Ser Arg Ser Pro Pro Ser
            740                 745                 750         
Asn Leu Ala Leu Ala Ser Glu Thr Pro Asp Ser Leu Gln Val Ser Trp
        755                 760                 765             
Thr Pro Pro Leu Gly Arg Val Leu His Tyr Trp Leu Thr Tyr Ala Pro
    770                 775                 780                 
Ala Ser Gly Leu Gly Pro Glu Lys Ser Val Ser Val Pro Gly Ala Arg
785                 790                 795                 800 
Ser His Val Thr Leu Pro Asp Leu Gln Ala Ala Thr Lys Tyr Arg Val
                805                 810                 815     
Leu Val Ser Ala Ile Tyr Ala Ala Gly Arg Ser Glu Ala Val Ser Ala
            820                 825                 830         
Thr Gly Gln Thr Ala Cys Pro Ala Leu Arg Pro Asp Gly Ser Leu Pro
        835                 840                 845             
Gly Phe Asp Leu Met Val Ala Phe Ser Leu Val Glu Lys Ala Tyr Ala
    850                 855                 860                 
Ser Ile Arg Gly Val Ala Met Glu Pro Ser Ala Phe Gly Gly Thr Pro
865                 870                 875                 880 
Thr Phe Thr Leu Phe Lys Asp Ala Gln Leu Thr Arg Arg Val Ser Asp
                885                 890                 895     
Val Tyr Pro Ala Pro Leu Pro Pro Glu His Thr Ile Val Phe Leu Val
            900                 905                 910         
Arg Leu Leu Pro Glu Thr Pro Arg Glu Ala Phe Ala Leu Trp Gln Met
        915                 920                 925             
Thr Ala Glu Asp Phe Gln Pro Leu Leu Gly Val Leu Leu Asp Ala Gly
    930                 935                 940                 
Lys Lys Ser Leu Thr Tyr Phe His Arg Asp Pro Arg Ala Ala Leu Gln
945                 950                 955                 960 
Glu Ala Thr Phe Asp Pro Gln Glu Val Arg Lys Ile Phe Phe Gly Ser
                965                 970                 975     
Phe His Lys Val His Val Ala Val Gly Arg Ser Lys Val Arg Leu Tyr
            980                 985                 990         
Val Asp Cys Arg Lys Val Ala Glu Arg Pro Leu Gly Glu Met Gly Ser
        995                 1000                1005            
Pro Pro Ala Ala Gly Phe Val Thr Leu Gly Arg Leu Ala Lys Ala Arg
    1010                1015                1020                
Gly Pro Arg Ser Ser Ser Ala Ala Phe Gln Leu Gln Met Leu Gln Ile
1025                1030                1035                1040
Val Cys Ser Asp Thr Trp Ala Asp Glu Asp Arg Cys Cys Glu Leu Pro
                1045                1050                1055    
Ala Ser Arg Asp Gly Glu Thr Cys Pro Ala Phe Val Ser Ala Cys Ser
            1060                1065                1070        
Cys Ser Ser Glu Thr Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly
        1075                1080                1085            
Leu Pro Gly Arg Asn Gly Thr Pro Gly Glu Gln Gly Phe Pro Gly Pro
    1090                1095                1100                
Arg Gly Pro Pro Gly Val Lys Gly Glu Lys Gly Asp His Gly Leu Pro
1105                1110                1115                1120
Gly Leu Gln Gly His Pro Gly His Gln Gly Ile Pro Gly Arg Val Gly
                1125                1130                1135    
Leu Gln Gly Pro Lys Gly Met Arg Gly Leu Glu Gly Thr Ala Gly Leu
            1140                1145                1150        
Pro Gly Pro Pro Gly Pro Arg Gly Phe Gln Gly Met Ala Gly Ala Arg
        1155                1160                1165            
Gly Thr Ser Gly Glu Arg Gly Pro Pro Gly Thr Val Gly Pro Thr Gly
    1170                1175                1180                
Leu Pro Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly Glu Pro Gln Ser
1185                1190                1195                1200
Leu Ala Thr Leu Tyr Gln Leu Val Ser Gln Ala Cys Glu Ser Ala Ile
                1205                1210                1215    
Gln Thr His Val Ser Lys Phe Asp Ser Phe His Glu Asn Thr Arg Pro
            1220                1225                1230        
Pro Met Pro Ile Leu Glu Gln Lys Leu Glu Pro Gly Thr Glu Pro Leu
        1235                1240                1245            
Gly Ser Pro Gly Thr Arg Ser Lys Ala Leu Val Pro Gly Glu Trp Gly
    1250                1255                1260                
Arg Gly Gly Arg His Leu Glu Gly Arg Gly Glu Pro Gly Ala Val Gly
1265                1270                1275                1280
Gln Met Gly Ser Pro Gly Gln Gln Gly Ala Ser Thr Gln Gly Leu Trp
                1285                1290                1295    
Glu
    


<210> 8943
<211> 1279
<212> PRT
<213> Homo sapiens

<400> 8943
Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp
 1               5                  10                  15      
Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu
            20                  25                  30          
Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu
        35                  40                  45              
Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala
    50                  55                  60                  
Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala
65                  70                  75                  80  
Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe
                85                  90                  95      
Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val
            100                 105                 110         
Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro
        115                 120                 125             
Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro
    130                 135                 140                 
Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln
145                 150                 155                 160 
Asp Pro Arg Thr Pro Gly Gly Ser Glu Trp Arg Glu Thr Gly Pro Gln
                165                 170                 175     
Phe Arg Cys Leu Pro Pro Val Pro Ala Asp Met Val Phe Leu Val Asp
            180                 185                 190         
Gly Ser Trp Ser Ile Gly His Ser His Phe Gln Gln Val Lys Asp Phe
        195                 200                 205             
Leu Ala Ser Val Ile Ala Pro Phe Glu Ile Gly Pro Asp Lys Val Gln
    210                 215                 220                 
Val Gly Leu Thr Gln Tyr Ser Gly Asp Ala Gln Thr Glu Trp Asp Leu
225                 230                 235                 240 
Asn Ser Leu Ser Thr Lys Glu Gln Val Leu Ala Ala Val Arg Arg Leu
                245                 250                 255     
Arg Tyr Lys Gly Gly Asn Thr Phe Thr Gly Leu Ala Leu Thr His Val
            260                 265                 270         
Leu Gly Gln Asn Leu Gln Pro Ala Ala Gly Leu Arg Pro Glu Ala Ala
        275                 280                 285             
Lys Val Val Ile Leu Val Thr Asp Gly Lys Ser Gln Asp Asp Val His
    290                 295                 300                 
Thr Ala Ala Arg Val Leu Lys Asp Leu Gly Val Asn Val Phe Ala Val
305                 310                 315                 320 
Gly Val Lys Asn Ala Asp Glu Ala Glu Leu Arg Leu Leu Ala Ser Pro
                325                 330                 335     
Pro Arg Asp Ile Thr Val His Ser Val Leu Asp Phe Leu Gln Leu Gly
            340                 345                 350         
Ala Leu Ala Gly Leu Leu Ser Arg Leu Ile Cys Gln Arg Leu Gln Gly
        355                 360                 365             
Gly Ser Pro Arg Gln Gly Pro Ala Ala Ala Pro Ala Leu Asp Thr Leu
    370                 375                 380                 
Pro Ala Pro Thr Ser Leu Val Leu Ser Gln Val Thr Ser Ser Ser Ile
385                 390                 395                 400 
Arg Leu Ser Trp Thr Pro Ala Pro Arg His Pro Leu Lys Tyr Leu Ile
                405                 410                 415     
Val Trp Arg Ala Ser Arg Gly Gly Thr Pro Arg Glu Val Val Val Glu
            420                 425                 430         
Gly Pro Ala Ala Ser Thr Glu Leu His Asn Leu Ala Ser Arg Thr Glu
        435                 440                 445             
Tyr Leu Val Ser Val Phe Pro Ile Tyr Glu Gly Gly Val Gly Glu Gly
    450                 455                 460                 
Leu Arg Gly Leu Val Thr Thr Ala Pro Leu Pro Pro Pro Arg Ala Leu
465                 470                 475                 480 
Thr Leu Ala Ala Val Thr Pro Arg Thr Val His Leu Thr Trp Gln Pro
                485                 490                 495     
Ser Ala Gly Ala Thr His Tyr Leu Val Arg Cys Ser Pro Ala Ser Pro
            500                 505                 510         
Lys Gly Glu Glu Glu Glu Arg Glu Val Gln Val Gly Arg Pro Glu Val
        515                 520                 525             
Leu Leu Asp Gly Leu Glu Pro Gly Arg Asp Tyr Glu Val Ser Val Gln
    530                 535                 540                 
Ser Leu Arg Gly Pro Glu Gly Ser Glu Ala Arg Gly Ile Arg Ala Arg
545                 550                 555                 560 
Thr Pro Thr Leu Ala Pro Pro Arg His Leu Gly Phe Ser Asp Val Ser
                565                 570                 575     
His Asp Ala Ala Arg Val Phe Trp Glu Gly Ala Pro Arg Pro Val Arg
            580                 585                 590         
Leu Val Arg Val Thr Tyr Val Ser Ser Glu Gly Gly His Ser Gly Gln
        595                 600                 605             
Thr Glu Ala Pro Gly Asn Ala Thr Ser Ala Met Leu Gly Pro Leu Ser
    610                 615                 620                 
Ser Ser Thr Thr Tyr Thr Val Arg Val Thr Cys Leu Tyr Pro Gly Gly
625                 630                 635                 640 
Gly Ser Ser Thr Leu Thr Gly Arg Val Thr Thr Lys Lys Ala Pro Ser
                645                 650                 655     
Pro Ser Gln Leu Ser Met Thr Glu Leu Pro Gly Asp Ala Val Gln Leu
            660                 665                 670         
Ala Trp Val Ala Ala Ala Pro Ser Gly Val Leu Val Tyr Gln Ile Thr
        675                 680                 685             
Trp Thr Pro Leu Gly Glu Gly Lys Ala His Glu Ile Ser Val Pro Gly
    690                 695                 700                 
Asn Leu Gly Thr Ala Val Leu Pro Gly Leu Gly Arg His Thr Glu Tyr
705                 710                 715                 720 
Asp Val Thr Ile Leu Ala Tyr Tyr Arg Asp Gly Ala Arg Ser Asp Pro
                725                 730                 735     
Val Ser Leu Arg Tyr Thr Pro Ser Thr Val Ser Arg Ser Pro Pro Ser
            740                 745                 750         
Asn Leu Ala Leu Ala Ser Glu Thr Pro Asp Ser Leu Gln Val Ser Trp
        755                 760                 765             
Thr Pro Pro Leu Gly Arg Val Leu His Tyr Trp Leu Thr Tyr Ala Pro
    770                 775                 780                 
Ala Ser Gly Leu Gly Pro Glu Lys Ser Val Ser Val Pro Gly Ala Arg
785                 790                 795                 800 
Ser His Val Thr Leu Pro Asp Leu Gln Ala Ala Thr Lys Tyr Arg Val
                805                 810                 815     
Leu Val Ser Ala Ile Tyr Ala Ala Gly Arg Ser Glu Ala Val Ser Ala
            820                 825                 830         
Thr Gly Gln Thr Ala Cys Pro Ala Leu Arg Pro Asp Gly Ser Leu Pro
        835                 840                 845             
Gly Phe Asp Leu Met Val Ala Phe Ser Leu Val Glu Lys Ala Tyr Ala
    850                 855                 860                 
Ser Ile Arg Gly Val Ala Met Glu Pro Ser Ala Phe Gly Gly Thr Pro
865                 870                 875                 880 
Thr Phe Thr Leu Phe Lys Asp Ala Gln Leu Thr Arg Arg Val Ser Asp
                885                 890                 895     
Val Tyr Pro Ala Pro Leu Pro Pro Glu His Thr Ile Val Phe Leu Val
            900                 905                 910         
Arg Leu Leu Pro Glu Thr Pro Arg Glu Ala Phe Ala Leu Trp Gln Met
        915                 920                 925             
Thr Ala Glu Asp Phe Gln Pro Leu Leu Gly Val Leu Leu Asp Ala Gly
    930                 935                 940                 
Lys Lys Ser Leu Thr Tyr Phe His Arg Asp Pro Arg Ala Ala Leu Gln
945                 950                 955                 960 
Glu Ala Thr Phe Asp Pro Gln Glu Val Arg Lys Ile Phe Phe Gly Ser
                965                 970                 975     
Phe His Lys Val His Val Ala Val Gly Arg Ser Lys Val Arg Leu Tyr
            980                 985                 990         
Val Asp Cys Arg Lys Val Ala Glu Arg Pro Leu Gly Glu Met Gly Ser
        995                 1000                1005            
Pro Pro Ala Ala Gly Phe Val Thr Leu Gly Arg Leu Ala Lys Ala Arg
    1010                1015                1020                
Gly Pro Arg Ser Ser Ser Ala Ala Phe Gln Leu Gln Met Leu Gln Ile
1025                1030                1035                1040
Val Cys Ser Asp Thr Trp Ala Asp Glu Asp Arg Cys Cys Glu Leu Pro
                1045                1050                1055    
Ala Ser Arg Asp Gly Glu Thr Cys Pro Ala Phe Val Ser Ala Cys Ser
            1060                1065                1070        
Cys Ser Ser Glu Thr Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly
        1075                1080                1085            
Pro Pro Gly Val Lys Gly Glu Lys Gly Asp His Gly Leu Pro Gly Leu
    1090                1095                1100                
Gln Gly His Pro Gly His Gln Gly Ile Pro Gly Arg Val Gly Leu Gln
1105                1110                1115                1120
Gly Pro Lys Gly Met Arg Gly Leu Glu Gly Thr Ala Gly Leu Pro Gly
                1125                1130                1135    
Pro Pro Gly Pro Arg Gly Phe Gln Gly Met Ala Gly Ala Arg Gly Thr
            1140                1145                1150        
Ser Gly Glu Arg Gly Pro Pro Gly Thr Val Gly Pro Thr Gly Leu Pro
        1155                1160                1165            
Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly Glu Pro Gln Ser Leu Ala
    1170                1175                1180                
Thr Leu Tyr Gln Leu Val Ser Gln Ala Cys Glu Ser Ala Ile Gln Thr
1185                1190                1195                1200
His Val Ser Lys Phe Asp Ser Phe His Glu Asn Thr Arg Pro Pro Met
                1205                1210                1215    
Pro Ile Leu Glu Gln Lys Leu Glu Pro Gly Thr Glu Pro Leu Gly Ser
            1220                1225                1230        
Pro Gly Thr Arg Ser Lys Ala Leu Val Pro Gly Glu Trp Gly Arg Gly
        1235                1240                1245            
Gly Arg His Leu Glu Gly Arg Gly Glu Pro Gly Ala Val Gly Gln Met
    1250                1255                1260                
Gly Ser Pro Gly Gln Gln Gly Ala Ser Thr Gln Gly Leu Trp Glu
1265                1270                1275                


<210> 8944
<211> 761
<212> PRT
<213> Homo sapiens

<400> 8944
Met Asn Trp Arg Phe Val Glu Leu Leu Tyr Phe Leu Phe Ile Trp Gly
 1               5                  10                  15      
Arg Ile Ser Val Gln Pro Ser His Gln Glu Pro Ala Gly Thr Asp Gln
            20                  25                  30          
His Val Ser Lys Glu Phe Asp Trp Leu Ile Ser Asp Arg Gly Pro Phe
        35                  40                  45              
His His Ser Arg Ser Tyr Leu Ser Phe Val Glu Arg His Arg Gln Gly
    50                  55                  60                  
Phe Thr Thr Arg Tyr Lys Ile Tyr Arg Glu Phe Ala Arg Trp Lys Val
65                  70                  75                  80  
Arg Asn Thr Ala Ile Glu Arg Arg Asp Leu Val Arg His Pro Val Pro
                85                  90                  95      
Leu Met Pro Glu Phe Gln Arg Ser Ile Arg Leu Leu Gly Arg Arg Pro
            100                 105                 110         
Thr Thr Gln Gln Phe Ile Asp Thr Ile Ile Lys Lys Tyr Gly Thr His
        115                 120                 125             
Leu Leu Ile Ser Ala Thr Leu Gly Gly Glu Glu Ala Leu Thr Met Tyr
    130                 135                 140                 
Met Asp Lys Ser Arg Leu Asp Arg Lys Ser Gly Asn Ala Thr Gln Ser
145                 150                 155                 160 
Val Glu Ala Leu His Gln Leu Ala Ser Ser Tyr Phe Val Asp Arg Asp
                165                 170                 175     
Gly Thr Met Arg Arg Leu His Glu Ile Gln Ile Ser Thr Gly Ala Ile
            180                 185                 190         
Lys Val Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Asn Ser Tyr Asp
        195                 200                 205             
Asn Leu Asp Ser Val Ser Ser Val Leu Leu Gln Ser Thr Glu Ser Lys
    210                 215                 220                 
Leu His Leu Gln Gly Leu Gln Ile Ile Phe Pro Gln Tyr Leu Gln Glu
225                 230                 235                 240 
Lys Phe Val Gln Ser Ala Leu Ser Tyr Ile Met Cys Asn Gly Glu Gly
                245                 250                 255     
Glu Tyr Leu Cys Gln Asn Ser Gln Cys Arg Cys Gln Cys Ala Glu Glu
            260                 265                 270         
Phe Pro Gln Cys Asn Cys Pro Ile Thr Asp Ile Gln Ile Met Glu Tyr
        275                 280                 285             
Thr Leu Ala Asn Met Ala Lys Ser Trp Ala Glu Ala Tyr Lys Asp Leu
    290                 295                 300                 
Glu Asn Ser Asp Glu Phe Lys Ser Phe Met Lys Arg Leu Pro Ser Asn
305                 310                 315                 320 
His Phe Leu Thr Ile Gly Ser Ile His Gln His Trp Gly Asn Asp Trp
                325                 330                 335     
Asp Leu Gln Asn Arg Tyr Lys Leu Leu Gln Ser Ala Thr Glu Ala Gln
            340                 345                 350         
Arg Gln Lys Ile Gln Arg Thr Ala Arg Lys Leu Phe Gly Leu Ser Val
        355                 360                 365             
Arg Cys Arg His Asn Pro Asn His Gln Leu Pro Arg Glu Arg Thr Ile
    370                 375                 380                 
Gln Gln Trp Leu Ala Arg Val Gln Ser Leu Leu Tyr Cys Asn Glu Asn
385                 390                 395                 400 
Gly Phe Trp Gly Thr Phe Leu Glu Ser Gln Arg Ser Cys Val Cys His
                405                 410                 415     
Gly Ser Thr Thr Leu Cys Gln Arg Pro Ile Pro Cys Val Ile Gly Gly
            420                 425                 430         
Asn Asn Ser Cys Thr Met Cys Ser Leu Ala Asn Ile Ser Leu Cys Gly
        435                 440                 445             
Ser Cys Asn Lys Gly Tyr Lys Leu Tyr Arg Gly Arg Cys Glu Pro Gln
    450                 455                 460                 
Asn Val Asp Ser Glu Arg Ser Glu Gln Phe Ile Ser Phe Glu Thr Asp
465                 470                 475                 480 
Leu Asp Phe Gln Asp Leu Glu Leu Lys Tyr Leu Leu Gln Lys Met Asp
                485                 490                 495     
Ser Arg Leu Tyr Val His Thr Thr Phe Ile Ser Asn Glu Ile Arg Leu
            500                 505                 510         
Asp Thr Phe Phe Asp Pro Arg Trp Arg Lys Arg Met Ser Leu Thr Leu
        515                 520                 525             
Lys Ser Asn Lys Asn Arg Met Asp Phe Ile His Met Val Ile Gly Met
    530                 535                 540                 
Ser Met Arg Ile Cys Gln Met Arg Asn Ser Ser Leu Asp Pro Met Phe
545                 550                 555                 560 
Phe Val Tyr Val Asn Pro Phe Ser Gly Ser His Ser Glu Gly Trp Asn
                565                 570                 575     
Met Pro Phe Gly Glu Phe Gly Tyr Pro Arg Trp Glu Lys Ile Arg Leu
            580                 585                 590         
Gln Asn Ser Gln Cys Tyr Asn Trp Thr Leu Leu Leu Gly Asn Arg Trp
        595                 600                 605             
Lys Thr Phe Phe Glu Thr Val His Ile Tyr Leu Arg Ser Arg Thr Arg
    610                 615                 620                 
Leu Pro Thr Leu Leu Arg Asn Glu Thr Gly Gln Gly Pro Val Asp Leu
625                 630                 635                 640 
Ser Asp Pro Ser Lys Arg Gln Phe Tyr Ile Lys Ile Ser Asp Val Gln
                645                 650                 655     
Val Phe Gly Tyr Ser Leu Arg Phe Asn Ala Asp Leu Leu Arg Ser Ala
            660                 665                 670         
Val Gln Gln Val Asn Gln Ser Tyr Thr Gln Gly Gly Gln Phe Tyr Ser
        675                 680                 685             
Ser Ser Ser Val Met Leu Leu Leu Leu Asp Ile Arg Asp Arg Ile Asn
    690                 695                 700                 
Arg Leu Ala Pro Pro Val Ala Pro Gly Lys Pro Gln Leu Asp Leu Phe
705                 710                 715                 720 
Ser Cys Met Leu Lys His Arg Leu Lys Leu Thr Asn Ser Glu Ile Ile
                725                 730                 735     
Arg Val Asn His Ala Leu Asp Leu Tyr Asn Thr Glu Ile Leu Lys Gln
            740                 745                 750         
Ser Asp Gln Met Thr Ala Lys Leu Cys
        755                 760     


<210> 8945
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8945
Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu
 1               5                  10                  15      
Leu Val Cys Ser Gly Leu Ala Cys Gly Pro Gly Arg Gly Phe Gly Lys
            20                  25                  30          
Arg Arg His Pro Lys Lys Leu Thr Pro Leu Ala Tyr Lys Gln Phe Ile
        35                  40                  45              
Pro Asn Val Ala Glu Lys Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly
    50                  55                  60                  
Lys Ile Ser Arg Asn Ser Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr
65                  70                  75                  80  
Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg
                85                  90                  95      
Leu Met Thr Gln Arg Cys Lys Asp Lys Leu Asn Ala Leu Ala Ile Ser
            100                 105                 110         
Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg Val Thr Glu Gly Trp
        115                 120                 125             
Asp Glu Asp Gly His His Ser Glu Glu Ser Leu His Tyr Glu Gly Arg
    130                 135                 140                 
Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg Ser Lys Tyr Gly Met
145                 150                 155                 160 
Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu
                165                 170                 175     
Ser Lys Ala His Ile His Cys Ser Val Lys Ala Glu Asn Ser Val Ala
            180                 185                 190         
Ala Lys Ser Gly Gly Cys Phe Pro Gly Ser Ala Thr Val His Leu Glu
        195                 200                 205             
Gln Gly Gly Thr Lys Leu Val Lys Asp Leu Ser Pro Gly Asp Arg Val
    210                 215                 220                 
Leu Ala Ala Asp Asp Gln Gly Arg Leu Leu Tyr Ser Asp Phe Leu Thr
225                 230                 235                 240 
Phe Leu Asp Arg Asp Asp Gly Ala Lys Lys Val Phe Tyr Val Ile Glu
                245                 250                 255     
Thr Arg Glu Pro Arg Glu Arg Leu Leu Leu Thr Ala Ala His Leu Leu
            260                 265                 270         
Phe Val Ala Pro His Asn Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser
        275                 280                 285             
Ser Gly Ser Gly Pro Pro Ser Gly Gly Ala Leu Gly Pro Arg Ala Leu
    290                 295                 300                 
Phe Ala Ser Arg Val Arg Pro Gly Gln Arg Val Tyr Val Val Ala Glu
305                 310                 315                 320 
Arg Asp Gly Asp Arg Arg Leu Leu Pro Ala Ala Val His Ser Val Thr
                325                 330                 335     
Leu Ser Glu Glu Ala Ala Gly Ala Tyr Ala Pro Leu Thr Ala Gln Gly
            340                 345                 350         
Thr Ile Leu Ile Asn Arg Val Leu Ala Ser Cys Tyr Ala Val Ile Glu
        355                 360                 365             
Glu His Ser Trp Ala His Arg Ala Phe Ala Pro Phe Arg Leu Ala His
    370                 375                 380                 
Ala Leu Leu Ala Ala Leu Ala Pro Ala Arg Thr Asp Arg Gly Gly Asp
385                 390                 395                 400 
Ser Gly Gly Gly Asp Arg Gly Gly Gly Gly Gly Arg Val Ala Leu Thr
                405                 410                 415     
Ala Pro Gly Ala Ala Asp Ala Pro Gly Ala Gly Ala Thr Ala Gly Ile
            420                 425                 430         
His Trp Tyr Ser Gln Leu Leu Tyr Gln Ile Gly Thr Trp Leu Leu Asp
        435                 440                 445             
Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser
    450                 455                 460         


<210> 8946
<211> 852
<212> PRT
<213> Homo sapiens

<400> 8946
Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe
 1               5                  10                  15      
Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys
            20                  25                  30          
Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu
        35                  40                  45              
Val Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Met Gln Val Met
    50                  55                  60                  
Asn Lys Thr Arg Arg Ile Met Glu Gln Gly Gly Ala His Phe Ile Asn
65                  70                  75                  80  
Ala Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Ile Leu
                85                  90                  95      
Thr Gly Lys Tyr Val His Asn His Asn Thr Tyr Thr Asn Asn Glu Asn
            100                 105                 110         
Cys Ser Ser Pro Ser Trp Gln Ala Gln His Glu Ser Arg Thr Phe Ala
        115                 120                 125             
Val Tyr Leu Asn Ser Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr
    130                 135                 140                 
Leu Asn Glu Tyr Asn Gly Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp
145                 150                 155                 160 
Val Gly Leu Leu Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg
                165                 170                 175     
Asn Gly Val Lys Glu Lys His Gly Ser Asp Tyr Ser Lys Asp Tyr Leu
            180                 185                 190         
Thr Asp Leu Ile Thr Asn Asp Ser Val Ser Phe Phe Arg Thr Ser Lys
        195                 200                 205             
Lys Met Tyr Pro His Arg Pro Val Leu Met Val Ile Ser His Ala Ala
    210                 215                 220                 
Pro His Gly Pro Glu Asp Ser Ala Pro Gln Tyr Ser Arg Leu Phe Pro
225                 230                 235                 240 
Asn Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Pro
                245                 250                 255     
Asp Lys His Trp Ile Met Arg Tyr Thr Gly Pro Met Lys Pro Ile His
            260                 265                 270         
Met Glu Phe Thr Asn Met Leu Gln Arg Lys Arg Leu Gln Thr Leu Met
        275                 280                 285             
Ser Val Asp Asp Ser Met Glu Thr Ile Tyr Asn Met Leu Val Glu Thr
    290                 295                 300                 
Gly Glu Leu Asp Asn Thr Tyr Ile Val Tyr Thr Ala Asp His Gly Tyr
305                 310                 315                 320 
His Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Glu
                325                 330                 335     
Phe Asp Ile Arg Val Pro Phe Tyr Val Arg Gly Pro Asn Val Glu Ala
            340                 345                 350         
Gly Cys Leu Asn Pro His Ile Val Leu Asn Ile Asp Leu Ala Pro Thr
        355                 360                 365             
Ile Leu Asp Ile Ala Gly Leu Asp Ile Pro Ala Asp Met Asp Gly Lys
    370                 375                 380                 
Ser Ile Leu Lys Leu Leu Asp Thr Glu Arg Pro Val Asn Arg Phe His
385                 390                 395                 400 
Leu Lys Lys Lys Met Arg Val Trp Arg Asp Ser Phe Leu Val Glu Arg
                405                 410                 415     
Gly Lys Leu Leu His Lys Arg Asp Asn Asp Lys Val Asp Ala Gln Glu
            420                 425                 430         
Glu Asn Phe Leu Pro Lys Tyr Gln Arg Val Lys Asp Leu Cys Gln Arg
        435                 440                 445             
Ala Glu Tyr Gln Thr Ala Cys Glu Gln Leu Gly Gln Lys Trp Gln Cys
    450                 455                 460                 
Val Glu Asp Ala Thr Gly Lys Leu Lys Leu His Lys Cys Lys Gly Pro
465                 470                 475                 480 
Met Arg Leu Gly Gly Ser Arg Ala Leu Ser Asn Leu Val Pro Lys Tyr
                485                 490                 495     
Tyr Gly Gln Gly Ser Glu Ala Cys Thr Cys Asp Ser Gly Asp Tyr Lys
            500                 505                 510         
Leu Ser Leu Ala Gly Arg Arg Lys Lys Leu Phe Lys Lys Lys Tyr Lys
        515                 520                 525             
Ala Ser Tyr Val Arg Ser Arg Ser Ile Arg Ser Val Ala Ile Glu Val
    530                 535                 540                 
Asp Gly Arg Val Tyr His Val Gly Leu Gly Asp Ala Ala Gln Pro Arg
545                 550                 555                 560 
Asn Leu Thr Lys Arg His Trp Pro Gly Ala Pro Glu Asp Gln Asp Asp
                565                 570                 575     
Lys Asp Gly Gly Asp Phe Ser Gly Thr Gly Gly Leu Pro Asp Tyr Ser
            580                 585                 590         
Ala Ala Asn Pro Ile Lys Val Thr His Arg Cys Tyr Ile Leu Glu Asn
        595                 600                 605             
Asp Thr Val Gln Cys Asp Leu Asp Leu Tyr Lys Ser Leu Gln Ala Trp
    610                 615                 620                 
Lys Asp His Lys Leu His Ile Asp His Glu Ile Glu Thr Leu Gln Asn
625                 630                 635                 640 
Lys Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Lys Lys Arg
                645                 650                 655     
Pro Glu Glu Cys Asp Cys His Lys Ile Ser Tyr His Thr Gln His Lys
            660                 665                 670         
Gly Arg Leu Lys His Arg Gly Ser Ser Leu His Pro Phe Arg Lys Gly
        675                 680                 685             
Leu Gln Glu Lys Asp Lys Val Trp Leu Leu Arg Glu Gln Lys Arg Lys
    690                 695                 700                 
Lys Lys Leu Arg Lys Leu Leu Lys Arg Leu Gln Asn Asn Asp Thr Cys
705                 710                 715                 720 
Ser Met Pro Gly Leu Thr Cys Phe Thr His Asp Asn Gln His Trp Gln
                725                 730                 735     
Thr Ala Pro Phe Trp Thr Leu Gly Pro Phe Cys Ala Cys Thr Ser Ala
            740                 745                 750         
Asn Asn Asn Thr Tyr Trp Cys Met Arg Thr Ile Asn Glu Thr His Asn
        755                 760                 765             
Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr Phe Asp Leu
    770                 775                 780                 
Asn Thr Asp Pro Tyr Gln Leu Met Asn Ala Val Asn Thr Leu Asp Arg
785                 790                 795                 800 
Asp Val Leu Asn Gln Leu His Val Gln Leu Met Glu Leu Arg Ser Cys
                805                 810                 815     
Lys Gly Tyr Lys Gln Cys Asn Pro Arg Thr Arg Asn Met Asp Leu Gly
            820                 825                 830         
Leu Lys Asp Gly Gly Ser Tyr Glu Gln Tyr Arg Gly Gln Leu Trp Glu
        835                 840                 845             
Gly Trp Glu Gly
    850         


<210> 8947
<211> 870
<212> PRT
<213> Homo sapiens

<400> 8947
Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe
 1               5                  10                  15      
Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys
            20                  25                  30          
Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu
        35                  40                  45              
Val Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Met Gln Val Met
    50                  55                  60                  
Asn Lys Thr Arg Arg Ile Met Glu Gln Gly Gly Ala His Phe Ile Asn
65                  70                  75                  80  
Ala Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Ile Leu
                85                  90                  95      
Thr Gly Lys Tyr Val His Asn His Asn Thr Tyr Thr Asn Asn Glu Asn
            100                 105                 110         
Cys Ser Ser Pro Ser Trp Gln Ala Gln His Glu Ser Arg Thr Phe Ala
        115                 120                 125             
Val Tyr Leu Asn Ser Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr
    130                 135                 140                 
Leu Asn Glu Tyr Asn Gly Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp
145                 150                 155                 160 
Val Gly Leu Leu Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg
                165                 170                 175     
Asn Gly Val Lys Glu Lys His Gly Ser Asp Tyr Ser Lys Asp Tyr Leu
            180                 185                 190         
Thr Asp Leu Ile Thr Asn Asp Ser Val Ser Phe Phe Arg Thr Ser Lys
        195                 200                 205             
Lys Met Tyr Pro His Arg Pro Val Leu Met Val Ile Ser His Ala Ala
    210                 215                 220                 
Pro His Gly Pro Glu Asp Ser Ala Pro Gln Tyr Ser Arg Leu Phe Pro
225                 230                 235                 240 
Asn Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Pro
                245                 250                 255     
Asp Lys His Trp Ile Met Arg Tyr Thr Gly Pro Met Lys Pro Ile His
            260                 265                 270         
Met Glu Phe Thr Asn Met Leu Gln Arg Lys Arg Leu Gln Thr Leu Met
        275                 280                 285             
Ser Val Asp Asp Ser Met Glu Thr Ile Tyr Asn Met Leu Val Glu Thr
    290                 295                 300                 
Gly Glu Leu Asp Asn Thr Tyr Ile Val Tyr Thr Ala Asp His Gly Tyr
305                 310                 315                 320 
His Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Glu
                325                 330                 335     
Phe Asp Ile Arg Val Pro Phe Tyr Val Arg Gly Pro Asn Val Glu Ala
            340                 345                 350         
Gly Cys Leu Asn Pro His Ile Val Leu Asn Ile Asp Leu Ala Pro Thr
        355                 360                 365             
Ile Leu Asp Ile Ala Gly Leu Asp Ile Pro Ala Asp Met Asp Gly Lys
    370                 375                 380                 
Ser Ile Leu Lys Leu Leu Asp Thr Glu Arg Pro Val Asn Arg Phe His
385                 390                 395                 400 
Leu Lys Lys Lys Met Arg Val Trp Arg Asp Ser Phe Leu Val Glu Arg
                405                 410                 415     
Gly Lys Leu Leu His Lys Arg Asp Asn Asp Lys Val Asp Ala Gln Glu
            420                 425                 430         
Glu Asn Phe Leu Pro Lys Tyr Gln Arg Val Lys Asp Leu Cys Gln Arg
        435                 440                 445             
Ala Glu Tyr Gln Thr Ala Cys Glu Gln Leu Gly Gln Lys Trp Gln Cys
    450                 455                 460                 
Val Glu Asp Ala Thr Gly Lys Leu Lys Leu His Lys Cys Lys Gly Pro
465                 470                 475                 480 
Met Arg Leu Gly Gly Ser Arg Ala Leu Ser Asn Leu Val Pro Lys Tyr
                485                 490                 495     
Tyr Gly Gln Gly Ser Glu Ala Cys Thr Cys Asp Ser Gly Asp Tyr Lys
            500                 505                 510         
Leu Ser Leu Ala Gly Arg Arg Lys Lys Leu Phe Lys Lys Lys Tyr Lys
        515                 520                 525             
Ala Ser Tyr Val Arg Ser Arg Ser Ile Arg Ser Val Ala Ile Glu Val
    530                 535                 540                 
Asp Gly Arg Val Tyr His Val Gly Leu Gly Asp Ala Ala Gln Pro Arg
545                 550                 555                 560 
Asn Leu Thr Lys Arg His Trp Pro Gly Ala Pro Glu Asp Gln Asp Asp
                565                 570                 575     
Lys Asp Gly Gly Asp Phe Ser Gly Thr Gly Gly Leu Pro Asp Tyr Ser
            580                 585                 590         
Ala Ala Asn Pro Ile Lys Val Thr His Arg Cys Tyr Ile Leu Glu Asn
        595                 600                 605             
Asp Thr Val Gln Cys Asp Leu Asp Leu Tyr Lys Ser Leu Gln Ala Trp
    610                 615                 620                 
Lys Asp His Lys Leu His Ile Asp His Glu Ile Glu Thr Leu Gln Asn
625                 630                 635                 640 
Lys Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Lys Lys Arg
                645                 650                 655     
Pro Glu Glu Cys Asp Cys His Lys Ile Ser Tyr His Thr Gln His Lys
            660                 665                 670         
Gly Arg Leu Lys His Arg Gly Ser Ser Leu His Pro Phe Arg Lys Gly
        675                 680                 685             
Leu Gln Glu Lys Asp Lys Val Trp Leu Leu Arg Glu Gln Lys Arg Lys
    690                 695                 700                 
Lys Lys Leu Arg Lys Leu Leu Lys Arg Leu Gln Asn Asn Asp Thr Cys
705                 710                 715                 720 
Ser Met Pro Gly Leu Thr Cys Phe Thr His Asp Asn Gln His Trp Gln
                725                 730                 735     
Thr Ala Pro Phe Trp Thr Leu Gly Pro Phe Cys Ala Cys Thr Ser Ala
            740                 745                 750         
Asn Asn Asn Thr Tyr Trp Cys Met Arg Thr Ile Asn Glu Thr His Asn
        755                 760                 765             
Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr Phe Asp Leu
    770                 775                 780                 
Asn Thr Asp Pro Tyr Gln Leu Met Asn Ala Val Asn Thr Leu Asp Arg
785                 790                 795                 800 
Asp Val Leu Asn Gln Leu His Val Gln Leu Met Glu Leu Arg Ser Cys
                805                 810                 815     
Lys Gly Tyr Lys Gln Cys Asn Pro Arg Thr Arg Asn Met Asp Leu Gly
            820                 825                 830         
Leu Lys Asp Gly Gly Ser Tyr Glu Gln Tyr Arg Gln Phe Gln Arg Arg
        835                 840                 845             
Lys Trp Pro Glu Met Lys Arg Pro Ser Ser Lys Ser Leu Gly Gln Leu
    850                 855                 860                 
Trp Glu Gly Trp Glu Gly
865                 870 


<210> 8948
<211> 622
<212> PRT
<213> Homo sapiens

<400> 8948
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu
 1               5                  10                  15      
Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu
            20                  25                  30          
Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys
        35                  40                  45              
Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg
    50                  55                  60                  
Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg
65                  70                  75                  80  
Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser
                85                  90                  95      
Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp
            100                 105                 110         
Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg
        115                 120                 125             
Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr
    130                 135                 140                 
Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys
145                 150                 155                 160 
His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile
                165                 170                 175     
Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg
            180                 185                 190         
Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe
        195                 200                 205             
Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu
    210                 215                 220                 
His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn
225                 230                 235                 240 
Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu
                245                 250                 255     
Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr
            260                 265                 270         
Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro
        275                 280                 285             
Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg
    290                 295                 300                 
Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro
305                 310                 315                 320 
Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro
                325                 330                 335     
Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile
            340                 345                 350         
Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp
        355                 360                 365             
Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp
    370                 375                 380                 
Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys
385                 390                 395                 400 
Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe
                405                 410                 415     
Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu
            420                 425                 430         
Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser
        435                 440                 445             
Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg
    450                 455                 460                 
Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe
465                 470                 475                 480 
Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg
                485                 490                 495     
Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr
            500                 505                 510         
Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys
        515                 520                 525             
Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe
    530                 535                 540                 
Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu
545                 550                 555                 560 
Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro
                565                 570                 575     
Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Gly Cys Tyr Asp
            580                 585                 590         
Leu Gln Val Gly Lys Pro Leu Leu Trp Asp Arg His Cys Phe Arg Leu
        595                 600                 605             
Ser Thr His Gly Pro Glu Met Leu Gly Thr Ala Leu Arg Gly
    610                 615                 620         


<210> 8949
<211> 986
<212> PRT
<213> Homo sapiens

<400> 8949
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu
 1               5                  10                  15      
Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu
            20                  25                  30          
Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys
        35                  40                  45              
Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg
    50                  55                  60                  
Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg
65                  70                  75                  80  
Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser
                85                  90                  95      
Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp
            100                 105                 110         
Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg
        115                 120                 125             
Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr
    130                 135                 140                 
Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys
145                 150                 155                 160 
His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile
                165                 170                 175     
Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg
            180                 185                 190         
Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe
        195                 200                 205             
Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu
    210                 215                 220                 
His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn
225                 230                 235                 240 
Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu
                245                 250                 255     
Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr
            260                 265                 270         
Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro
        275                 280                 285             
Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg
    290                 295                 300                 
Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro
305                 310                 315                 320 
Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro
                325                 330                 335     
Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile
            340                 345                 350         
Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp
        355                 360                 365             
Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp
    370                 375                 380                 
Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys
385                 390                 395                 400 
Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe
                405                 410                 415     
Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu
            420                 425                 430         
Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser
        435                 440                 445             
Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg
    450                 455                 460                 
Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe
465                 470                 475                 480 
Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg
                485                 490                 495     
Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr
            500                 505                 510         
Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys
        515                 520                 525             
Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe
    530                 535                 540                 
Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu
545                 550                 555                 560 
Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro
                565                 570                 575     
Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly
            580                 585                 590         
Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro
        595                 600                 605             
Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro
    610                 615                 620                 
Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly
625                 630                 635                 640 
Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr
                645                 650                 655     
Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu
            660                 665                 670         
Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp
        675                 680                 685             
Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Asp Lys
    690                 695                 700                 
Asp Glu Cys Ser Lys Asp Asn Gly Gly Cys Gln Gln Asp Cys Val Asn
705                 710                 715                 720 
Thr Phe Gly Ser Tyr Glu Cys Gln Cys Arg Ser Gly Phe Val Leu His
                725                 730                 735     
Asp Asn Lys His Asp Cys Lys Glu Ala Gly Cys Asp His Lys Val Thr
            740                 745                 750         
Ser Thr Ser Gly Thr Ile Thr Ser Pro Asn Trp Pro Asp Lys Tyr Pro
        755                 760                 765             
Ser Lys Lys Glu Cys Thr Trp Ala Ile Ser Ser Thr Pro Gly His Arg
    770                 775                 780                 
Val Lys Leu Thr Phe Met Glu Met Asp Ile Glu Ser Gln Pro Glu Cys
785                 790                 795                 800 
Ala Tyr Asp His Leu Glu Val Phe Asp Gly Arg Asp Ala Lys Ala Pro
                805                 810                 815     
Val Leu Gly Arg Phe Cys Gly Ser Lys Lys Pro Glu Pro Val Leu Ala
            820                 825                 830         
Thr Gly Ser Arg Met Phe Leu Arg Phe Tyr Ser Asp Asn Ser Val Gln
        835                 840                 845             
Arg Lys Gly Phe Gln Ala Ser His Ala Thr Glu Cys Gly Gly Gln Val
    850                 855                 860                 
Arg Ala Asp Val Lys Thr Lys Asp Leu Tyr Ser His Ala Gln Phe Gly
865                 870                 875                 880 
Asp Asn Asn Tyr Pro Gly Gly Val Asp Cys Glu Trp Val Ile Val Ala
                885                 890                 895     
Glu Glu Gly Tyr Gly Val Glu Leu Val Phe Gln Thr Phe Glu Val Glu
            900                 905                 910         
Glu Glu Thr Asp Cys Gly Tyr Asp Tyr Met Glu Leu Phe Asp Gly Tyr
        915                 920                 925             
Asp Ser Thr Ala Pro Arg Leu Gly Arg Tyr Cys Gly Ser Gly Pro Pro
    930                 935                 940                 
Glu Glu Val Tyr Ser Ala Gly Asp Ser Val Leu Val Lys Phe His Ser
945                 950                 955                 960 
Asp Asp Thr Ile Thr Lys Lys Gly Phe His Leu Arg Tyr Thr Ser Thr
                965                 970                 975     
Lys Phe Gln Asp Thr Leu His Ser Arg Lys
            980                 985     


<210> 8950
<211> 717
<212> PRT
<213> Homo sapiens

<400> 8950
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu
 1               5                  10                  15      
Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu
            20                  25                  30          
Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys
        35                  40                  45              
Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg
    50                  55                  60                  
Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg
65                  70                  75                  80  
Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser
                85                  90                  95      
Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp
            100                 105                 110         
Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg
        115                 120                 125             
Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr
    130                 135                 140                 
Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys
145                 150                 155                 160 
His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile
                165                 170                 175     
Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg
            180                 185                 190         
Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe
        195                 200                 205             
Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu
    210                 215                 220                 
His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn
225                 230                 235                 240 
Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu
                245                 250                 255     
Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr
            260                 265                 270         
Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro
        275                 280                 285             
Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg
    290                 295                 300                 
Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro
305                 310                 315                 320 
Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro
                325                 330                 335     
Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile
            340                 345                 350         
Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp
        355                 360                 365             
Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp
    370                 375                 380                 
Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys
385                 390                 395                 400 
Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe
                405                 410                 415     
Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu
            420                 425                 430         
Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser
        435                 440                 445             
Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg
    450                 455                 460                 
Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe
465                 470                 475                 480 
Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg
                485                 490                 495     
Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr
            500                 505                 510         
Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys
        515                 520                 525             
Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe
    530                 535                 540                 
Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu
545                 550                 555                 560 
Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro
                565                 570                 575     
Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly
            580                 585                 590         
Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro
        595                 600                 605             
Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro
    610                 615                 620                 
Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly
625                 630                 635                 640 
Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr
                645                 650                 655     
Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu
            660                 665                 670         
Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp
        675                 680                 685             
Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Gly Gly
    690                 695                 700                 
Glu Leu Phe Gly Leu Leu Gly His Pro Pro Arg Arg Pro
705                 710                 715         


<210> 8951
<211> 730
<212> PRT
<213> Homo sapiens

<400> 8951
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu
 1               5                  10                  15      
Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu
            20                  25                  30          
Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys
        35                  40                  45              
Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg
    50                  55                  60                  
Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg
65                  70                  75                  80  
Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser
                85                  90                  95      
Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp
            100                 105                 110         
Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg
        115                 120                 125             
Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr
    130                 135                 140                 
Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys
145                 150                 155                 160 
His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile
                165                 170                 175     
Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg
            180                 185                 190         
Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe
        195                 200                 205             
Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu
    210                 215                 220                 
His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn
225                 230                 235                 240 
Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu
                245                 250                 255     
Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr
            260                 265                 270         
Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro
        275                 280                 285             
Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg
    290                 295                 300                 
Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro
305                 310                 315                 320 
Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro
                325                 330                 335     
Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile
            340                 345                 350         
Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp
        355                 360                 365             
Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp
    370                 375                 380                 
Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys
385                 390                 395                 400 
Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe
                405                 410                 415     
Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu
            420                 425                 430         
Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser
        435                 440                 445             
Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg
    450                 455                 460                 
Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe
465                 470                 475                 480 
Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg
                485                 490                 495     
Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr
            500                 505                 510         
Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys
        515                 520                 525             
Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe
    530                 535                 540                 
Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu
545                 550                 555                 560 
Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro
                565                 570                 575     
Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly
            580                 585                 590         
Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro
        595                 600                 605             
Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro
    610                 615                 620                 
Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly
625                 630                 635                 640 
Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr
                645                 650                 655     
Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu
            660                 665                 670         
Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp
        675                 680                 685             
Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Glu Lys
    690                 695                 700                 
Arg Pro Ala Leu Gln Pro Pro Arg Gly Arg Pro His Gln Leu Lys Phe
705                 710                 715                 720 
Arg Val Gln Lys Arg Asn Arg Thr Pro Gln
                725                 730 


<210> 8952
<211> 823
<212> PRT
<213> Homo sapiens

<400> 8952
Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu
 1               5                  10                  15      
Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu
            20                  25                  30          
Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys
        35                  40                  45              
Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg
    50                  55                  60                  
Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg
65                  70                  75                  80  
Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser
                85                  90                  95      
Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp
            100                 105                 110         
Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg
        115                 120                 125             
Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr
    130                 135                 140                 
Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys
145                 150                 155                 160 
His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile
                165                 170                 175     
Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg
            180                 185                 190         
Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe
        195                 200                 205             
Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu
    210                 215                 220                 
His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn
225                 230                 235                 240 
Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu
                245                 250                 255     
Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr
            260                 265                 270         
Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro
        275                 280                 285             
Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg
    290                 295                 300                 
Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro
305                 310                 315                 320 
Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro
                325                 330                 335     
Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile
            340                 345                 350         
Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp
        355                 360                 365             
Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp
    370                 375                 380                 
Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys
385                 390                 395                 400 
Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe
                405                 410                 415     
Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu
            420                 425                 430         
Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser
        435                 440                 445             
Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg
    450                 455                 460                 
Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe
465                 470                 475                 480 
Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg
                485                 490                 495     
Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr
            500                 505                 510         
Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys
        515                 520                 525             
Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe
    530                 535                 540                 
Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu
545                 550                 555                 560 
Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro
                565                 570                 575     
Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly
            580                 585                 590         
Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro
        595                 600                 605             
Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro
    610                 615                 620                 
Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly
625                 630                 635                 640 
Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr
                645                 650                 655     
Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu
            660                 665                 670         
Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp
        675                 680                 685             
Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Val Leu
    690                 695                 700                 
Glu Gly Ala Gly Asp Arg His Ser His Leu Ser Gly Leu Glu Leu Leu
705                 710                 715                 720 
Leu Cys Pro His Ala Leu Val Asp Thr Val Pro Ala Pro Pro Ser Ala
                725                 730                 735     
Leu His Gly Asp Thr His Ala His Thr His Thr His Val His Thr His
            740                 745                 750         
Cys Pro Ile Ala Gln Glu Thr Cys Arg Gly Pro Pro Leu Gly Ala Ser
        755                 760                 765             
Arg Leu Ser Pro Gln Gly Pro Gly His Leu Thr Leu Ala Pro Gln Glu
    770                 775                 780                 
Gly Ser Tyr Leu Asp Phe Trp Asp Thr His Arg Gly Asp Pro Lys Pro
785                 790                 795                 800 
Arg Arg Arg Arg Lys Ser Leu Lys Thr Phe Ser Leu Thr Pro Ala Thr
                805                 810                 815     
Phe Arg Gly Ile Trp Ala Leu
            820             


<210> 8953
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8953
Met Ala Cys Thr Gly Trp Thr Ser Pro Leu Pro Leu Cys Val Cys Leu
 1               5                  10                  15      
Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Val Val Val Pro
            20                  25                  30          
Met Asp Gly Ser His Trp Phe Thr Met Arg Ser Val Val Glu Lys Leu
        35                  40                  45              
Ile Leu Arg Gly His Glu Val Val Val Val Ser Ala Arg Gly Glu Leu
    50                  55                  60                  
Ala Thr Gly Lys Ile Asn Glu Leu His Ser Glu Asp Leu Phe Asn Phe
65                  70                  75                  80  
Ile Tyr Leu Glu Asp Leu Asp Arg Glu Phe Lys Ala Phe Ala His Ala
                85                  90                  95      
Gln Trp Lys Ala Gln Val Arg Ser Ile Tyr Ser Leu Leu Met Gly Ser
            100                 105                 110         
Tyr Asn Asp Ile Phe Asp Leu Phe Phe Ser Asn Cys Arg Ser Leu Phe
        115                 120                 125             
Lys Asp Lys Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala
    130                 135                 140                 
Val Phe Leu Asp Pro Phe Asp Asn Cys Gly Leu Ile Val Ala Lys Tyr
145                 150                 155                 160 
Phe Ser Leu Pro Ser Val Val Phe Ala Arg Gly Ile Leu Cys His Tyr
                165                 170                 175     
Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Arg
            180                 185                 190         
Ile Leu Leu Gly Phe Ser Asp Asp Met Thr Phe Lys Glu Arg Val Arg
        195                 200                 205             
Asn His Ile Met His Leu Glu Glu His Leu Leu Cys His Arg Phe Phe
    210                 215                 220                 
Lys Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr
225                 230                 235                 240 
Glu Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp
                245                 250                 255     
Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile
            260                 265                 270         
Gly Gly Ile Asn Cys His Glu Arg Lys Ala Leu Pro Met Glu Phe Glu
        275                 280                 285             
Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu
    290                 295                 300                 
Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala
305                 310                 315                 320 
Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly
                325                 330                 335     
Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu
            340                 345                 350         
Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr
        355                 360                 365             
His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro
    370                 375                 380                 
Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg
385                 390                 395                 400 
Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr
                405                 410                 415     
Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser
            420                 425                 430         
Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro
        435                 440                 445             
Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg
    450                 455                 460                 
His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp
465                 470                 475                 480 
Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val
                485                 490                 495     
Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg
            500                 505                 510         
Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys
        515                 520                 525             
Thr His
    530 


<210> 8954
<211> 2828
<212> PRT
<213> Homo sapiens

<400> 8954
Met Pro Lys Arg Ala His Trp Gly Ala Leu Ser Val Val Leu Ile Leu
 1               5                  10                  15      
Leu Trp Gly His Pro Arg Val Ala Leu Ala Cys Pro His Pro Cys Ala
            20                  25                  30          
Cys Tyr Val Pro Ser Glu Val His Cys Thr Phe Arg Ser Leu Ala Ser
        35                  40                  45              
Val Pro Ala Gly Ile Ala Arg His Val Glu Arg Ile Asn Leu Gly Phe
    50                  55                  60                  
Asn Ser Ile Gln Ala Leu Ser Glu Thr Ser Phe Ala Gly Leu Thr Lys
65                  70                  75                  80  
Leu Glu Leu Leu Met Ile His Gly Asn Glu Ile Pro Ser Ile Pro Asp
                85                  90                  95      
Gly Ala Leu Arg Asp Leu Ser Ser Leu Gln Val Phe Lys Phe Ser Tyr
            100                 105                 110         
Asn Lys Leu Arg Val Ile Thr Gly Gln Thr Leu Gln Gly Leu Ser Asn
        115                 120                 125             
Leu Met Arg Leu His Ile Asp His Asn Lys Ile Glu Phe Ile His Pro
    130                 135                 140                 
Gln Ala Phe Asn Gly Leu Thr Ser Leu Arg Leu Leu His Leu Glu Gly
145                 150                 155                 160 
Asn Leu Leu His Gln Leu His Pro Ser Thr Phe Ser Thr Phe Thr Phe
                165                 170                 175     
Leu Asp Tyr Phe Arg Leu Ser Thr Ile Arg His Leu Tyr Leu Ala Glu
            180                 185                 190         
Asn Met Val Arg Thr Leu Pro Ala Ser Met Leu Arg Asn Met Pro Leu
        195                 200                 205             
Leu Glu Asn Leu Tyr Leu Gln Gly Asn Pro Trp Thr Cys Asp Cys Glu
    210                 215                 220                 
Met Arg Trp Phe Leu Glu Trp Asp Ala Lys Ser Arg Gly Ile Leu Lys
225                 230                 235                 240 
Cys Lys Lys Asp Lys Ala Tyr Glu Gly Gly Gln Leu Cys Ala Met Cys
                245                 250                 255     
Phe Ser Pro Lys Lys Leu Tyr Lys His Glu Ile His Lys Leu Lys Asp
            260                 265                 270         
Met Thr Cys Leu Lys Pro Ser Ile Glu Ser Pro Leu Arg Gln Asn Arg
        275                 280                 285             
Ser Arg Ser Ile Glu Glu Glu Gln Glu Gln Glu Glu Asp Gly Gly Ser
    290                 295                 300                 
Gln Leu Ile Leu Glu Lys Phe Gln Leu Pro Gln Trp Ser Ile Ser Leu
305                 310                 315                 320 
Asn Met Thr Asp Glu His Gly Asn Met Val Asn Leu Val Cys Asp Ile
                325                 330                 335     
Lys Lys Pro Met Asp Val Tyr Lys Ile His Leu Asn Gln Thr Asp Pro
            340                 345                 350         
Pro Asp Ile Asp Ile Asn Ala Thr Val Ala Leu Asp Phe Glu Cys Pro
        355                 360                 365             
Met Thr Arg Glu Asn Tyr Glu Lys Leu Trp Lys Leu Ile Ala Tyr Tyr
    370                 375                 380                 
Ser Glu Val Pro Val Lys Leu His Arg Glu Leu Met Leu Ser Lys Asp
385                 390                 395                 400 
Pro Arg Val Ser Tyr Gln Tyr Arg Gln Asp Ala Asp Glu Glu Ala Leu
                405                 410                 415     
Tyr Tyr Thr Gly Val Arg Ala Gln Ile Leu Ala Glu Pro Glu Trp Val
            420                 425                 430         
Met Gln Pro Ser Ile Asp Ile Gln Leu Asn Arg Arg Gln Ser Thr Ala
        435                 440                 445             
Lys Lys Val Leu Leu Ser Tyr Tyr Thr Gln Tyr Ser Gln Thr Ile Ser
    450                 455                 460                 
Thr Lys Asp Thr Arg Gln Ala Arg Gly Arg Ser Trp Val Met Ile Glu
465                 470                 475                 480 
Pro Ser Gly Ala Val Gln Arg Asp Gln Thr Val Leu Glu Gly Gly Pro
                485                 490                 495     
Cys Gln Leu Ser Cys Asn Val Lys Ala Ser Glu Ser Pro Ser Ile Phe
            500                 505                 510         
Trp Val Leu Pro Asp Gly Ser Ile Leu Lys Ala Pro Met Asp Asp Pro
        515                 520                 525             
Asp Ser Lys Phe Ser Ile Leu Ser Ser Gly Trp Leu Arg Ile Lys Ser
    530                 535                 540                 
Met Glu Pro Ser Asp Ser Gly Leu Tyr Gln Cys Ile Ala Gln Val Arg
545                 550                 555                 560 
Asp Glu Met Asp Arg Met Val Tyr Arg Val Leu Val Gln Ser Pro Ser
                565                 570                 575     
Thr Gln Pro Ala Glu Lys Asp Thr Val Thr Ile Gly Lys Asn Pro Gly
            580                 585                 590         
Glu Ser Val Thr Leu Pro Cys Asn Ala Leu Ala Ile Pro Glu Ala His
        595                 600                 605             
Leu Ser Trp Ile Leu Pro Asn Arg Arg Ile Ile Asn Asp Leu Ala Asn
    610                 615                 620                 
Thr Ser His Val Tyr Met Leu Pro Asn Gly Thr Leu Ser Ile Pro Lys
625                 630                 635                 640 
Val Gln Val Ser Asp Ser Gly Tyr Tyr Arg Cys Val Ala Val Asn Gln
                645                 650                 655     
Gln Gly Ala Asp His Phe Thr Val Gly Ile Thr Val Thr Lys Lys Gly
            660                 665                 670         
Ser Gly Leu Pro Ser Lys Arg Gly Arg Arg Pro Gly Ala Lys Ala Leu
        675                 680                 685             
Ser Arg Val Arg Glu Asp Ile Val Glu Asp Glu Gly Gly Ser Gly Met
    690                 695                 700                 
Gly Asp Glu Glu Asn Thr Ser Arg Arg Leu Leu His Pro Lys Asp Gln
705                 710                 715                 720 
Glu Val Phe Leu Lys Thr Lys Asp Asp Ala Ile Asn Gly Asp Lys Lys
                725                 730                 735     
Ala Lys Lys Gly Arg Arg Lys Leu Lys Leu Trp Lys His Ser Glu Lys
            740                 745                 750         
Glu Pro Glu Thr Asn Val Ala Glu Gly Arg Arg Val Phe Glu Ser Arg
        755                 760                 765             
Arg Arg Ile Asn Met Ala Asn Lys Gln Ile Asn Pro Glu Arg Trp Ala
    770                 775                 780                 
Asp Ile Leu Ala Lys Val Arg Gly Lys Asn Leu Pro Lys Gly Thr Glu
785                 790                 795                 800 
Val Pro Pro Leu Ile Lys Thr Thr Ser Pro Pro Ser Leu Ser Leu Glu
                805                 810                 815     
Val Thr Pro Pro Phe Pro Ala Val Ser Pro Pro Ser Ala Ser Pro Val
            820                 825                 830         
Gln Thr Val Thr Ser Ala Glu Glu Ser Ser Ala Asp Val Pro Leu Leu
        835                 840                 845             
Gly Glu Glu Glu His Val Leu Gly Thr Ile Ser Ser Ala Ser Met Gly
    850                 855                 860                 
Leu Glu His Asn His Asn Gly Val Ile Leu Val Glu Pro Glu Val Thr
865                 870                 875                 880 
Ser Thr Pro Leu Glu Glu Val Val Asp Asp Leu Ser Glu Lys Thr Glu
                885                 890                 895     
Glu Ile Thr Ser Thr Glu Gly Asp Leu Lys Gly Thr Ala Ala Pro Thr
            900                 905                 910         
Leu Ile Ser Glu Pro Tyr Glu Pro Ser Pro Thr Leu His Thr Leu Asp
        915                 920                 925             
Thr Val Tyr Glu Lys Pro Thr His Glu Glu Thr Ala Thr Glu Gly Trp
    930                 935                 940                 
Ser Ala Ala Asp Val Gly Ser Ser Pro Glu Pro Thr Ser Ser Glu Tyr
945                 950                 955                 960 
Glu Pro Pro Leu Asp Ala Val Ser Leu Ala Glu Ser Glu Pro Met Gln
                965                 970                 975     
Tyr Phe Asp Pro Asp Leu Glu Thr Lys Ser Gln Pro Asp Glu Asp Lys
            980                 985                 990         
Met Lys Glu Asp Thr Phe Ala His Leu Thr Pro Thr Pro Thr Ile Trp
        995                 1000                1005            
Val Asn Asp Ser Ser Thr Ser Gln Leu Phe Glu Asp Ser Thr Ile Gly
    1010                1015                1020                
Glu Pro Gly Val Pro Gly Gln Ser His Leu Gln Gly Leu Thr Asp Asn
1025                1030                1035                1040
Ile His Leu Val Lys Ser Ser Leu Ser Thr Gln Asp Thr Leu Leu Ile
                1045                1050                1055    
Lys Lys Gly Met Lys Glu Met Ser Gln Thr Leu Gln Gly Gly Asn Met
            1060                1065                1070        
Leu Glu Gly Asp Pro Thr His Ser Arg Ser Ser Glu Ser Glu Gly Gln
        1075                1080                1085            
Glu Ser Lys Ser Ile Thr Leu Pro Asp Ser Thr Leu Gly Ile Met Ser
    1090                1095                1100                
Ser Met Ser Pro Val Lys Lys Pro Ala Glu Thr Thr Val Gly Thr Leu
1105                1110                1115                1120
Leu Asp Lys Asp Thr Thr Thr Val Thr Thr Thr Pro Arg Gln Lys Val
                1125                1130                1135    
Ala Pro Ser Ser Thr Met Ser Thr His Pro Ser Arg Arg Arg Pro Asn
            1140                1145                1150        
Gly Arg Arg Arg Leu Arg Pro Asn Lys Phe Arg His Arg His Lys Gln
        1155                1160                1165            
Thr Pro Pro Thr Thr Phe Ala Pro Ser Glu Thr Phe Ser Thr Gln Pro
    1170                1175                1180                
Thr Gln Ala Pro Asp Ile Lys Ile Ser Ser Gln Val Glu Ser Ser Leu
1185                1190                1195                1200
Val Pro Thr Ala Trp Val Asp Asn Thr Val Asn Thr Pro Lys Gln Leu
                1205                1210                1215    
Glu Met Glu Lys Asn Ala Glu Pro Thr Ser Lys Gly Thr Pro Arg Arg
            1220                1225                1230        
Lys His Gly Lys Arg Pro Asn Lys His Arg Tyr Thr Pro Ser Thr Val
        1235                1240                1245            
Ser Ser Arg Ala Ser Gly Ser Lys Pro Ser Pro Ser Pro Glu Asn Lys
    1250                1255                1260                
His Arg Asn Ile Val Thr Pro Ser Ser Glu Thr Ile Leu Leu Pro Arg
1265                1270                1275                1280
Thr Val Ser Leu Lys Thr Glu Gly Pro Tyr Asp Ser Leu Asp Tyr Met
                1285                1290                1295    
Thr Thr Thr Arg Lys Ile Tyr Ser Ser Tyr Pro Lys Val Gln Glu Thr
            1300                1305                1310        
Leu Pro Val Thr Tyr Lys Pro Thr Ser Asp Gly Lys Glu Ile Lys Asp
        1315                1320                1325            
Asp Val Ala Thr Asn Val Asp Lys His Lys Ser Asp Ile Leu Val Thr
    1330                1335                1340                
Gly Glu Ser Ile Thr Asn Ala Ile Pro Thr Ser Arg Ser Leu Val Ser
1345                1350                1355                1360
Thr Met Gly Glu Phe Lys Glu Glu Ser Ser Pro Val Gly Phe Pro Gly
                1365                1370                1375    
Thr Pro Thr Trp Asn Pro Ser Arg Thr Ala Gln Pro Gly Arg Leu Gln
            1380                1385                1390        
Thr Asp Ile Pro Val Thr Thr Ser Gly Glu Asn Leu Thr Asp Pro Pro
        1395                1400                1405            
Leu Leu Lys Glu Leu Glu Asp Val Asp Phe Thr Ser Glu Phe Leu Ser
    1410                1415                1420                
Ser Leu Thr Val Ser Thr Pro Phe His Gln Glu Glu Ala Gly Ser Ser
1425                1430                1435                1440
Thr Thr Leu Ser Ser Ile Lys Val Glu Val Ala Ser Ser Gln Ala Glu
                1445                1450                1455    
Thr Thr Thr Leu Asp Gln Asp His Leu Glu Thr Thr Val Ala Ile Leu
            1460                1465                1470        
Leu Ser Glu Thr Arg Pro Gln Asn His Thr Pro Thr Ala Ala Arg Met
        1475                1480                1485            
Lys Glu Pro Ala Ser Ser Ser Pro Ser Thr Ile Leu Met Ser Leu Gly
    1490                1495                1500                
Gln Thr Thr Thr Thr Lys Pro Ala Leu Pro Ser Pro Arg Ile Ser Gln
1505                1510                1515                1520
Ala Ser Arg Asp Ser Lys Glu Asn Val Phe Leu Asn Tyr Val Gly Asn
                1525                1530                1535    
Pro Glu Thr Glu Ala Thr Pro Val Asn Asn Glu Gly Thr Gln His Met
            1540                1545                1550        
Ser Gly Pro Asn Glu Leu Ser Thr Pro Ser Ser Asp Arg Asp Ala Phe
        1555                1560                1565            
Asn Leu Ser Thr Lys Leu Glu Leu Glu Lys Gln Val Phe Gly Ser Arg
    1570                1575                1580                
Ser Leu Pro Arg Gly Pro Asp Ser Gln Arg Gln Asp Gly Arg Val His
1585                1590                1595                1600
Ala Ser His Gln Leu Thr Arg Val Pro Ala Lys Pro Ile Leu Pro Thr
                1605                1610                1615    
Ala Thr Val Arg Leu Pro Glu Met Ser Thr Gln Ser Ala Ser Arg Tyr
            1620                1625                1630        
Phe Val Thr Ser Gln Ser Pro Arg His Trp Thr Asn Lys Pro Glu Ile
        1635                1640                1645            
Thr Thr Tyr Pro Ser Gly Ala Leu Pro Glu Asn Lys Gln Phe Thr Thr
    1650                1655                1660                
Pro Arg Leu Ser Ser Thr Thr Ile Pro Leu Pro Leu His Met Ser Lys
1665                1670                1675                1680
Pro Ser Ile Pro Ser Lys Phe Thr Asp Arg Arg Thr Asp Gln Phe Asn
                1685                1690                1695    
Gly Tyr Ser Lys Val Phe Gly Asn Asn Asn Ile Pro Glu Ala Arg Asn
            1700                1705                1710        
Pro Val Gly Lys Pro Pro Ser Pro Arg Ile Pro His Tyr Ser Asn Gly
        1715                1720                1725            
Arg Leu Pro Phe Phe Thr Asn Lys Thr Leu Ser Phe Pro Gln Leu Gly
    1730                1735                1740                
Val Thr Arg Arg Pro Gln Ile Pro Thr Ser Pro Ala Pro Val Met Arg
1745                1750                1755                1760
Glu Arg Lys Val Ile Pro Gly Ser Tyr Asn Arg Ile His Ser His Ser
                1765                1770                1775    
Thr Phe His Leu Asp Phe Gly Pro Pro Ala Pro Pro Leu Leu His Thr
            1780                1785                1790        
Pro Gln Thr Thr Gly Ser Pro Ser Thr Asn Leu Gln Asn Ile Pro Met
        1795                1800                1805            
Val Ser Ser Thr Gln Ser Ser Ile Ser Phe Ile Thr Ser Ser Val Gln
    1810                1815                1820                
Ser Ser Gly Ser Phe His Gln Ser Ser Ser Lys Phe Phe Ala Gly Gly
1825                1830                1835                1840
Pro Pro Ala Ser Lys Phe Trp Ser Leu Gly Glu Lys Pro Gln Ile Leu
                1845                1850                1855    
Thr Lys Ser Pro Gln Thr Val Ser Val Thr Ala Glu Thr Asp Thr Val
            1860                1865                1870        
Phe Pro Cys Glu Ala Thr Gly Lys Pro Lys Pro Phe Val Thr Trp Thr
        1875                1880                1885            
Lys Val Ser Thr Gly Ala Leu Met Thr Pro Asn Thr Arg Ile Gln Arg
    1890                1895                1900                
Phe Glu Val Leu Lys Asn Gly Thr Leu Val Ile Arg Lys Val Gln Val
1905                1910                1915                1920
Gln Asp Arg Gly Gln Tyr Met Cys Thr Ala Ser Asn Leu His Gly Leu
                1925                1930                1935    
Asp Arg Met Val Val Leu Leu Ser Val Thr Val Gln Gln Pro Gln Ile
            1940                1945                1950        
Leu Ala Ser His Tyr Gln Asp Val Thr Val Tyr Leu Gly Asp Thr Ile
        1955                1960                1965            
Ala Met Glu Cys Leu Ala Lys Gly Thr Pro Ala Pro Gln Ile Ser Trp
    1970                1975                1980                
Ile Phe Pro Asp Arg Arg Val Trp Gln Thr Val Ser Pro Val Glu Ser
1985                1990                1995                2000
Arg Ile Thr Leu His Glu Asn Arg Thr Leu Ser Ile Lys Glu Ala Ser
                2005                2010                2015    
Phe Ser Asp Arg Gly Val Tyr Lys Cys Val Ala Ser Asn Ala Ala Gly
            2020                2025                2030        
Ala Asp Ser Leu Ala Ile Arg Leu His Val Ala Ala Leu Pro Pro Val
        2035                2040                2045            
Ile His Gln Glu Lys Leu Glu Asn Ile Ser Leu Pro Pro Gly Leu Ser
    2050                2055                2060                
Ile His Ile His Cys Thr Ala Lys Ala Ala Pro Leu Pro Ser Val Arg
2065                2070                2075                2080
Trp Val Leu Gly Asp Gly Thr Gln Ile Arg Pro Ser Gln Phe Leu His
                2085                2090                2095    
Gly Asn Leu Phe Val Phe Pro Asn Gly Thr Leu Tyr Ile Arg Asn Leu
            2100                2105                2110        
Ala Pro Lys Asp Ser Gly Arg Tyr Glu Cys Val Ala Ala Asn Leu Val
        2115                2120                2125            
Gly Ser Ala Arg Arg Thr Val Gln Leu Asn Val Gln Arg Ala Ala Ala
    2130                2135                2140                
Asn Ala Arg Ile Thr Gly Thr Ser Pro Arg Arg Thr Asp Val Arg Tyr
2145                2150                2155                2160
Gly Gly Thr Leu Lys Leu Asp Cys Ser Ala Ser Gly Asp Pro Trp Pro
                2165                2170                2175    
Arg Ile Leu Trp Arg Leu Pro Ser Lys Arg Met Ile Asp Ala Leu Phe
            2180                2185                2190        
Ser Phe Asp Ser Arg Ile Lys Val Phe Ala Asn Gly Thr Leu Val Val
        2195                2200                2205            
Lys Ser Val Thr Asp Lys Asp Ala Gly Asp Tyr Leu Cys Val Ala Arg
    2210                2215                2220                
Asn Lys Val Gly Asp Asp Tyr Val Val Leu Lys Val Asp Val Val Met
2225                2230                2235                2240
Lys Pro Ala Lys Ile Glu His Lys Glu Glu Asn Asp His Lys Val Phe
                2245                2250                2255    
Tyr Gly Gly Asp Leu Lys Val Asp Cys Val Ala Thr Gly Leu Pro Asn
            2260                2265                2270        
Pro Glu Ile Ser Trp Ser Leu Pro Asp Gly Ser Leu Val Asn Ser Phe
        2275                2280                2285            
Met Gln Ser Asp Asp Ser Gly Gly Arg Thr Lys Arg Tyr Val Val Phe
    2290                2295                2300                
Asn Asn Gly Thr Leu Tyr Phe Asn Glu Val Gly Met Arg Glu Glu Gly
2305                2310                2315                2320
Asp Tyr Thr Cys Phe Ala Glu Asn Gln Val Gly Lys Asp Glu Met Arg
                2325                2330                2335    
Val Arg Val Lys Val Val Thr Ala Pro Ala Thr Ile Arg Asn Lys Thr
            2340                2345                2350        
Tyr Leu Ala Val Gln Val Pro Tyr Gly Asp Val Val Thr Val Ala Cys
        2355                2360                2365            
Glu Ala Lys Gly Glu Pro Met Pro Lys Val Thr Trp Leu Ser Pro Thr
    2370                2375                2380                
Asn Lys Val Ile Pro Thr Ser Ser Glu Lys Tyr Gln Ile Tyr Gln Asp
2385                2390                2395                2400
Gly Thr Leu Leu Ile Gln Lys Ala Gln Arg Ser Asp Ser Gly Asn Tyr
                2405                2410                2415    
Thr Cys Leu Val Arg Asn Ser Ala Gly Glu Asp Arg Lys Thr Val Trp
            2420                2425                2430        
Ile His Val Asn Val Gln Pro Pro Lys Ile Asn Gly Asn Pro Asn Pro
        2435                2440                2445            
Ile Thr Thr Val Arg Glu Ile Ala Ala Gly Gly Ser Arg Lys Leu Ile
    2450                2455                2460                
Asp Cys Lys Ala Glu Gly Ile Pro Thr Pro Arg Val Leu Trp Ala Phe
2465                2470                2475                2480
Pro Glu Gly Val Val Leu Pro Ala Pro Tyr Tyr Gly Asn Arg Ile Thr
                2485                2490                2495    
Val His Gly Asn Gly Ser Leu Asp Ile Arg Ser Leu Arg Lys Ser Asp
            2500                2505                2510        
Ser Val Gln Leu Val Cys Met Ala Arg Asn Glu Gly Gly Glu Ala Arg
        2515                2520                2525            
Leu Ile Val Gln Leu Thr Val Leu Glu Pro Met Glu Lys Pro Ile Phe
    2530                2535                2540                
His Asp Pro Ile Ser Glu Lys Ile Thr Ala Met Ala Gly His Thr Ile
2545                2550                2555                2560
Ser Leu Asn Cys Ser Ala Ala Gly Thr Pro Thr Pro Ser Leu Val Trp
                2565                2570                2575    
Val Leu Pro Asn Gly Thr Asp Leu Gln Ser Gly Gln Gln Leu Gln Arg
            2580                2585                2590        
Phe Tyr His Lys Ala Asp Gly Met Leu His Ile Ser Gly Leu Ser Ser
        2595                2600                2605            
Val Asp Ala Gly Ala Tyr Arg Cys Val Ala Arg Asn Ala Ala Gly His
    2610                2615                2620                
Thr Glu Arg Leu Val Ser Leu Lys Val Gly Leu Lys Pro Glu Ala Asn
2625                2630                2635                2640
Lys Gln Tyr His Asn Leu Val Ser Ile Ile Asn Gly Glu Thr Leu Lys
                2645                2650                2655    
Leu Pro Cys Thr Pro Pro Gly Ala Gly Gln Gly Arg Phe Ser Trp Thr
            2660                2665                2670        
Leu Pro Asn Gly Met His Leu Glu Gly Pro Gln Thr Leu Gly Arg Val
        2675                2680                2685            
Ser Leu Leu Asp Asn Gly Thr Leu Thr Val Arg Glu Ala Ser Val Phe
    2690                2695                2700                
Asp Arg Gly Thr Tyr Val Cys Arg Met Glu Thr Glu Tyr Gly Pro Ser
2705                2710                2715                2720
Val Thr Ser Ile Pro Val Ile Val Ile Ala Tyr Pro Pro Arg Ile Thr
                2725                2730                2735    
Ser Glu Pro Thr Pro Val Ile Tyr Thr Arg Pro Gly Asn Thr Val Lys
            2740                2745                2750        
Leu Asn Cys Met Ala Met Gly Ile Pro Lys Ala Asp Ile Thr Trp Glu
        2755                2760                2765            
Leu Pro Asp Lys Ser His Leu Lys Ala Gly Val Gln Ala Arg Leu Tyr
    2770                2775                2780                
Gly Asn Arg Phe Leu His Pro Gln Gly Ser Leu Thr Ile Gln His Ala
2785                2790                2795                2800
Thr Gln Arg Asp Ala Gly Phe Tyr Lys Cys Met Ala Lys Asn Ile Leu
                2805                2810                2815    
Gly Ser Asp Ser Lys Thr Thr Tyr Ile His Val Phe
            2820                2825            


<210> 8955
<211> 583
<212> PRT
<213> Homo sapiens

<400> 8955
Ile Glu His Lys Glu Glu Asn Asp His Lys Val Phe Tyr Arg Gly Asp
 1               5                  10                  15      
Leu Lys Val Asp Cys Val Ala Thr Gly Leu Pro Asn Pro Glu Ile Ser
            20                  25                  30          
Trp Ser Leu Leu Asp Gly Ser Leu Val Asn Ser Phe Met Gln Ser Asp
        35                  40                  45              
Asp Ser Gly Gly Arg Thr Lys His Tyr Val Val Phe Asn Asn Gly Thr
    50                  55                  60                  
Leu Tyr Phe Ser Glu Val Gly Met Arg Glu Glu Gly Asp Tyr Thr Cys
65                  70                  75                  80  
Phe Ala Glu Asn Gln Val Gly Lys Asp Glu Met Arg Val Arg Val Lys
                85                  90                  95      
Met Val Thr Pro Ala Thr Ile Trp Asn Lys Thr Tyr Leu Ala Val Gln
            100                 105                 110         
Val Pro Tyr Gly Asp Val Val Thr Val Thr Cys Glu Ala Lys Gly Glu
        115                 120                 125             
Pro Met Pro Lys Val Thr Trp Leu Ser Pro Ala Asn Arg Val Ile Pro
    130                 135                 140                 
Thr Ser Ser Glu Lys Tyr Gln Ile Tyr Gln Tyr Gly Thr Leu Leu Ile
145                 150                 155                 160 
Gln Lys Ala Gln Cys Ser Asp Ser Gly Asn Tyr Thr Cys Leu Val Arg
                165                 170                 175     
Asn Ser Ala Gly Glu Asp Arg Lys Thr Val Trp Ile His Val Asn Leu
            180                 185                 190         
Gln Pro Pro Lys Ile Asn Gly Asn Pro Asn Pro Ile Thr Thr Val Trp
        195                 200                 205             
Glu Ile Ala Ala Gly Gly Ser Arg Lys Leu Ile Asp Cys Lys Ala Glu
    210                 215                 220                 
Gly Ile Pro Thr Pro Arg Val Leu Trp Ala Phe Pro Glu Gly Val Val
225                 230                 235                 240 
Leu Pro Asp Pro Tyr Tyr Gly Asn Arg Ile Thr Val His Gly Asn Gly
                245                 250                 255     
Ser Leu Asp Ile Arg Ser Leu Arg Lys Ser Asp Ser Val Gln Leu Val
            260                 265                 270         
Cys Met Ala Arg Asn Glu Gly Gly Glu Ala Arg Leu Ile Val Gln Leu
        275                 280                 285             
Thr Val Leu Glu Pro Met Glu Lys Pro Ile Phe His Asp Pro Ile Ser
    290                 295                 300                 
Glu Lys Ile Thr Ala Met Ala Gly His Thr Ile Ser Leu Asn Cys Ser
305                 310                 315                 320 
Ala Ala Gly Thr Leu Thr Pro Ser Leu Val Trp Val Leu Pro Asn Gly
                325                 330                 335     
Thr Asp Leu Gln Ser Gly Gln Gln Leu Gln Arg Phe Tyr His Lys Ala
            340                 345                 350         
Asp Gly Met Leu His Ile Ser Gly Leu Ser Ser Val Asp Ala Gly Ala
        355                 360                 365             
Tyr Arg Cys Val Ala Arg Asn Ala Ala Gly His Thr Glu Arg Leu Val
    370                 375                 380                 
Ser Leu Lys Val Gly Leu Lys Pro Glu Ala Asn Lys Gln Tyr His Asn
385                 390                 395                 400 
Leu Val Ser Ile Ile Asn Gly Glu Thr Leu Lys Leu Pro Cys Thr Pro
                405                 410                 415     
Pro Ala Ala Gly Gln Gly His Phe Ser Trp Thr Leu Pro Asn Gly Met
            420                 425                 430         
His Leu Glu Gly Pro Gln Thr Leu Gly Arg Val Ser Leu Leu Asp Asn
        435                 440                 445             
Gly Thr Leu Thr Val Arg Glu Ala Ser Val Phe Asp Arg Gly Thr Tyr
    450                 455                 460                 
Val Cys Arg Met Glu Thr Ala Tyr Gly Pro Ser Val Thr Ser Ile Pro
465                 470                 475                 480 
Val Ile Val Ile Ala Tyr Pro Pro Arg Ile Thr Ser Glu Pro Thr Pro
                485                 490                 495     
Val Ile Tyr Thr Arg Pro Gly Asn Thr Val Lys Leu Asn Cys Met Ala
            500                 505                 510         
Met Gly Ile Pro Lys Gly Asp Ile Thr Trp Glu Leu Pro Asp Lys Leu
        515                 520                 525             
His Leu Lys Ala Gly Val Gln Ala Arg Leu Tyr Gly Asn Arg Phe Leu
    530                 535                 540                 
His Pro Gln Gly Ser Leu Thr Ile Gln Gln Ala Arg Arg Arg Asp Ala
545                 550                 555                 560 
Gly Phe Tyr Lys Cys Thr Ala Lys Asn Ile Leu Ser Ser Asp Ser Lys
                565                 570                 575     
Thr Thr Tyr Ile His Val Phe
            580             


<210> 8956
<211> 1007
<212> PRT
<213> Homo sapiens

<400> 8956
Met Gly Ser Gly Gly Asp Ser Leu Leu Gly Gly Arg Gly Ser Leu Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Ile Met Gly Gly Met Ala Gln Asp Ser Pro Pro
            20                  25                  30          
Gln Ile Leu Val His Pro Gln Asp Gln Leu Phe Gln Gly Pro Gly Pro
        35                  40                  45              
Ala Arg Met Ser Cys Gln Ala Ser Gly Gln Pro Pro Pro Thr Ile Arg
    50                  55                  60                  
Trp Leu Leu Asn Gly Gln Pro Leu Ser Met Val Pro Pro Asp Pro His
65                  70                  75                  80  
His Leu Leu Pro Asp Gly Thr Leu Leu Leu Leu Gln Pro Pro Ala Arg
                85                  90                  95      
Gly His Ala His Asp Gly Gln Ala Leu Ser Thr Asp Leu Gly Val Tyr
            100                 105                 110         
Thr Cys Glu Ala Ser Asn Arg Leu Gly Thr Ala Val Ser Arg Gly Ala
        115                 120                 125             
Arg Leu Ser Val Ala Val Leu Arg Glu Asp Phe Gln Ile Gln Pro Arg
    130                 135                 140                 
Asp Met Val Ala Val Val Gly Glu Gln Phe Thr Leu Glu Cys Gly Pro
145                 150                 155                 160 
Pro Trp Gly His Pro Glu Pro Thr Val Ser Trp Trp Lys Asp Gly Lys
                165                 170                 175     
Pro Leu Ala Leu Gln Pro Gly Arg His Thr Val Ser Gly Gly Ser Leu
            180                 185                 190         
Leu Met Ala Arg Ala Glu Lys Ser Asp Glu Gly Thr Tyr Met Cys Val
        195                 200                 205             
Ala Thr Asn Ser Ala Gly His Arg Glu Ser Arg Ala Ala Arg Val Ser
    210                 215                 220                 
Ile Gln Glu Pro Gln Asp Tyr Thr Glu Pro Val Glu Leu Leu Ala Val
225                 230                 235                 240 
Arg Ile Gln Leu Glu Asn Val Thr Leu Leu Asn Pro Asp Pro Ala Glu
                245                 250                 255     
Gly Pro Lys Pro Arg Pro Ala Val Trp Leu Ser Trp Lys Val Ser Gly
            260                 265                 270         
Pro Ala Ala Pro Ala Gln Ser Tyr Thr Ala Leu Phe Arg Thr Gln Thr
        275                 280                 285             
Ala Pro Gly Gly Gln Gly Ala Pro Trp Ala Glu Glu Leu Leu Ala Gly
    290                 295                 300                 
Trp Gln Ser Ala Glu Leu Gly Gly Leu His Trp Gly Gln Asp Tyr Glu
305                 310                 315                 320 
Phe Lys Val Arg Pro Ser Ser Gly Arg Ala Arg Gly Pro Asp Ser Asn
                325                 330                 335     
Val Leu Leu Leu Arg Leu Pro Glu Lys Val Pro Ser Ala Pro Pro Gln
            340                 345                 350         
Glu Val Thr Leu Lys Pro Gly Asn Gly Thr Val Phe Val Ser Trp Val
        355                 360                 365             
Pro Pro Pro Ala Glu Asn His Asn Gly Ile Ile Arg Gly Tyr Gln Val
    370                 375                 380                 
Trp Ser Leu Gly Asn Thr Ser Leu Pro Pro Ala Asn Trp Thr Val Val
385                 390                 395                 400 
Gly Glu Gln Thr Gln Leu Glu Ile Ala Thr His Met Pro Gly Ser Tyr
                405                 410                 415     
Cys Val Gln Val Ala Ala Val Thr Gly Ala Gly Ala Gly Glu Pro Ser
            420                 425                 430         
Arg Pro Val Cys Leu Leu Leu Glu Gln Ala Met Glu Arg Ala Thr Gln
        435                 440                 445             
Glu Pro Ser Glu His Gly Pro Trp Thr Leu Glu Gln Leu Arg Ala Thr
    450                 455                 460                 
Leu Lys Arg Pro Glu Val Ile Ala Thr Cys Gly Val Ala Leu Trp Leu
465                 470                 475                 480 
Leu Leu Leu Gly Thr Ala Val Cys Ile His Arg Arg Arg Arg Ala Arg
                485                 490                 495     
Val His Leu Gly Pro Gly Leu Tyr Arg Tyr Thr Ser Glu Asp Ala Ile
            500                 505                 510         
Leu Lys His Arg Met Asp His Ser Asp Ser Gln Trp Leu Ala Asp Thr
        515                 520                 525             
Trp Arg Ser Thr Ser Gly Ser Arg Asp Leu Ser Ser Ser Ser Ser Leu
    530                 535                 540                 
Ser Ser Arg Leu Gly Ala Asp Ala Arg Asp Pro Leu Asp Cys Arg Arg
545                 550                 555                 560 
Ser Leu Leu Ser Trp Asp Ser Arg Ser Pro Gly Val Pro Leu Leu Pro
                565                 570                 575     
Asp Thr Ser Thr Phe Tyr Gly Ser Leu Ile Ala Glu Leu Pro Ser Ser
            580                 585                 590         
Thr Pro Ala Arg Pro Ser Pro Gln Val Pro Ala Val Arg Arg Leu Pro
        595                 600                 605             
Pro Gln Leu Ala Gln Leu Ser Ser Pro Cys Ser Ser Ser Asp Ser Leu
    610                 615                 620                 
Cys Ser Arg Arg Gly Leu Ser Ser Pro Arg Leu Ser Leu Ala Pro Ala
625                 630                 635                 640 
Glu Ala Trp Lys Ala Lys Lys Lys Gln Glu Leu Gln His Ala Asn Ser
                645                 650                 655     
Ser Pro Leu Leu Arg Gly Ser His Ser Leu Glu Leu Arg Ala Cys Glu
            660                 665                 670         
Leu Gly Asn Arg Gly Ser Lys Asn Leu Ser Gln Ser Pro Gly Ala Val
        675                 680                 685             
Pro Gln Ala Leu Val Ala Trp Arg Ala Leu Gly Pro Lys Leu Leu Ser
    690                 695                 700                 
Ser Ser Asn Glu Leu Val Thr Arg His Leu Pro Pro Ala Pro Leu Phe
705                 710                 715                 720 
Pro His Glu Thr Pro Pro Thr Gln Ser Gln Gln Thr Gln Pro Pro Val
                725                 730                 735     
Ala Pro Gln Ala Pro Ser Ser Ile Leu Leu Pro Ala Ala Pro Ile Pro
            740                 745                 750         
Ile Leu Ser Pro Cys Ser Pro Pro Ser Pro Gln Ala Ser Ser Leu Ser
        755                 760                 765             
Gly Pro Ser Pro Ala Ser Ser Arg Leu Ser Ser Ser Ser Leu Ser Ser
    770                 775                 780                 
Leu Gly Glu Asp Gln Asp Ser Val Leu Thr Pro Glu Glu Val Ala Leu
785                 790                 795                 800 
Cys Leu Glu Leu Ser Glu Gly Glu Glu Thr Pro Arg Asn Ser Val Ser
                805                 810                 815     
Pro Met Pro Arg Ala Pro Ser Pro Pro Thr Thr Tyr Gly Tyr Ile Ser
            820                 825                 830         
Val Pro Thr Ala Ser Glu Phe Thr Asp Met Gly Arg Thr Gly Gly Gly
        835                 840                 845             
Val Gly Pro Lys Gly Gly Val Leu Leu Cys Pro Pro Arg Pro Cys Leu
    850                 855                 860                 
Thr Pro Thr Pro Ser Glu Gly Ser Leu Ala Asn Gly Trp Gly Ser Ala
865                 870                 875                 880 
Ser Glu Asp Asn Ala Ala Ser Ala Arg Ala Ser Leu Val Ser Ser Ser
                885                 890                 895     
Asp Gly Ser Phe Leu Ala Asp Ala His Phe Ala Arg Ala Leu Ala Val
            900                 905                 910         
Ala Val Asp Ser Phe Gly Phe Gly Leu Glu Pro Arg Glu Ala Asp Cys
        915                 920                 925             
Val Phe Ile Asp Ala Ser Ser Pro Pro Ser Pro Arg Asp Glu Ile Phe
    930                 935                 940                 
Leu Thr Pro Asn Leu Ser Leu Pro Leu Trp Glu Trp Arg Pro Asp Trp
945                 950                 955                 960 
Leu Glu Asp Met Glu Val Ser His Thr Gln Arg Leu Gly Arg Gly Met
                965                 970                 975     
Pro Pro Trp Pro Pro Asp Ser Gln Ile Ser Ser Gln Arg Ser Gln Leu
            980                 985                 990         
His Cys Arg Met Pro Lys Ala Gly Ala Ser Pro Val Asp Tyr Ser
        995                 1000                1005        


<210> 8957
<211> 791
<212> PRT
<213> Homo sapiens

<400> 8957
Met Gly Ser Gly Gly Asp Ser Leu Leu Gly Gly Arg Gly Ser Leu Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Ile Met Gly Gly Met Ala Gln Asp Ser Pro Pro
            20                  25                  30          
Gln Ile Leu Val His Pro Gln Asp Gln Leu Phe Gln Gly Pro Gly Pro
        35                  40                  45              
Ala Arg Met Ser Cys Gln Ala Ser Gly Gln Pro Pro Pro Thr Ile Arg
    50                  55                  60                  
Trp Leu Leu Asn Gly Gln Pro Leu Ser Met Val Pro Pro Asp Pro His
65                  70                  75                  80  
His Leu Leu Pro Asp Gly Thr Leu Leu Leu Leu Gln Pro Pro Ala Arg
                85                  90                  95      
Gly His Ala His Asp Gly Gln Ala Leu Ser Thr Asp Leu Gly Val Tyr
            100                 105                 110         
Thr Cys Glu Ala Ser Asn Arg Leu Gly Thr Ala Val Ser Arg Gly Ala
        115                 120                 125             
Arg Leu Ser Val Ala Val Leu Arg Glu Asp Phe Gln Ile Gln Pro Arg
    130                 135                 140                 
Asp Met Val Ala Val Val Gly Glu Gln Phe Thr Leu Glu Cys Gly Pro
145                 150                 155                 160 
Pro Trp Gly His Pro Glu Pro Thr Val Ser Trp Trp Lys Asp Gly Lys
                165                 170                 175     
Pro Leu Ala Leu Gln Pro Gly Arg His Thr Val Ser Gly Gly Ser Leu
            180                 185                 190         
Leu Met Ala Arg Ala Glu Lys Ser Asp Glu Gly Thr Tyr Met Cys Val
        195                 200                 205             
Ala Thr Asn Ser Ala Gly His Arg Glu Ser Arg Ala Ala Arg Val Ser
    210                 215                 220                 
Ile Gln Glu Pro Gln Asp Tyr Thr Glu Pro Val Glu Leu Leu Ala Val
225                 230                 235                 240 
Arg Ile Gln Leu Glu Asn Val Thr Leu Leu Asn Pro Asp Pro Ala Glu
                245                 250                 255     
Gly Pro Lys Pro Arg Pro Ala Val Trp Leu Ser Trp Lys Val Ser Gly
            260                 265                 270         
Pro Ala Ala Pro Ala Gln Ser Tyr Thr Ala Leu Phe Arg Thr Gln Thr
        275                 280                 285             
Ala Pro Gly Gly Gln Gly Ala Pro Trp Ala Glu Glu Leu Leu Ala Gly
    290                 295                 300                 
Trp Gln Ser Ala Glu Leu Gly Gly Leu His Trp Gly Gln Asp Tyr Glu
305                 310                 315                 320 
Phe Lys Val Arg Pro Ser Ser Gly Arg Ala Arg Gly Pro Asp Ser Asn
                325                 330                 335     
Val Leu Leu Leu Arg Leu Pro Glu Lys Val Pro Ser Ala Pro Pro Gln
            340                 345                 350         
Glu Val Thr Leu Lys Pro Gly Asn Gly Thr Val Phe Val Ser Trp Val
        355                 360                 365             
Pro Pro Pro Ala Glu Asn His Asn Gly Ile Ile Arg Gly Tyr Gln Val
    370                 375                 380                 
Trp Ser Leu Gly Asn Thr Ser Leu Pro Pro Ala Asn Trp Thr Val Val
385                 390                 395                 400 
Gly Glu Gln Thr Gln Leu Glu Ile Ala Thr His Met Pro Gly Ser Tyr
                405                 410                 415     
Cys Val Gln Val Ala Ala Val Thr Gly Ala Gly Ala Gly Glu Pro Ser
            420                 425                 430         
Arg Pro Val Cys Leu Leu Leu Glu Gln Ala Met Glu Arg Ala Thr Gln
        435                 440                 445             
Glu Pro Ser Glu His Gly Pro Trp Thr Leu Glu Gln Leu Arg Ala Thr
    450                 455                 460                 
Leu Lys Arg Pro Glu Val Ile Ala Thr Cys Gly Val Ala Leu Trp Leu
465                 470                 475                 480 
Leu Leu Leu Gly Thr Ala Val Cys Ile His Arg Arg Arg Arg Ala Arg
                485                 490                 495     
Val His Leu Gly Pro Gly Leu Tyr Arg Tyr Thr Ser Glu Asp Ala Ile
            500                 505                 510         
Leu Lys His Arg Met Asp His Ser Asp Ser Gln Trp Leu Ala Asp Thr
        515                 520                 525             
Trp Arg Ser Thr Ser Gly Ser Arg Asp Leu Ser Ser Ser Ser Ser Leu
    530                 535                 540                 
Ser Ser Arg Leu Gly Ala Asp Ala Arg Asp Pro Leu Asp Cys Arg Arg
545                 550                 555                 560 
Ser Leu Leu Ser Trp Asp Ser Arg Ser Pro Gly Val Pro Leu Leu Pro
                565                 570                 575     
Asp Thr Ser Thr Phe Tyr Gly Ser Leu Ile Ala Glu Leu Pro Ser Ser
            580                 585                 590         
Thr Pro Ala Arg Pro Ser Pro Gln Val Pro Ala Val Arg Arg Leu Pro
        595                 600                 605             
Pro Gln Leu Ala Gln Leu Ser Ser Pro Cys Ser Ser Ser Asp Ser Leu
    610                 615                 620                 
Cys Ser Arg Arg Gly Leu Ser Ser Pro Arg Leu Ser Leu Ala Pro Ala
625                 630                 635                 640 
Glu Ala Trp Lys Ala Lys Lys Lys Gln Glu Leu Gln His Ala Asn Ser
                645                 650                 655     
Ser Pro Leu Leu Arg Gly Ser His Ser Leu Glu Leu Arg Ala Cys Glu
            660                 665                 670         
Leu Gly Asn Arg Gly Ser Lys Asn Leu Ser Gln Ser Pro Gly Ala Val
        675                 680                 685             
Pro Gln Ala Leu Val Ala Trp Arg Ala Leu Gly Pro Lys Leu Leu Ser
    690                 695                 700                 
Gln Met Ser Trp Leu Leu Val Ile Ser Leu Gln His Pro Ser Phe Leu
705                 710                 715                 720 
Met Lys Leu Pro Gln Leu Arg Val Asn Arg Pro Ser Leu Arg Trp His
                725                 730                 735     
His Arg Leu Pro Pro Pro Ser Cys Cys Gln Gln Pro Pro Ser Pro Ser
            740                 745                 750         
Leu Ala Pro Ala Val Pro Leu Ala Pro Arg Pro Leu Pro Ser Leu Ala
        755                 760                 765             
Pro Ala Gln Leu Pro Val Ala Cys Pro Ala Pro His Cys His Pro Trp
    770                 775                 780                 
Gly Arg Ile Lys Thr Ala Cys
785                 790     


<210> 8958
<211> 792
<212> PRT
<213> Homo sapiens

<400> 8958
Met Gly Ser Gly Gly Asp Ser Leu Leu Gly Gly Arg Gly Ser Leu Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Ile Met Gly Gly Met Ala Gln Asp Ser Pro Pro
            20                  25                  30          
Gln Ile Leu Val His Pro Gln Asp Gln Leu Phe Gln Gly Pro Gly Pro
        35                  40                  45              
Ala Arg Met Ser Cys Gln Ala Ser Gly Gln Pro Pro Pro Thr Ile Arg
    50                  55                  60                  
Trp Leu Leu Asn Gly Gln Pro Leu Ser Met Val Pro Pro Asp Pro His
65                  70                  75                  80  
His Leu Leu Pro Asp Gly Thr Leu Leu Leu Leu Gln Pro Pro Ala Arg
                85                  90                  95      
Gly His Ala His Asp Gly Gln Ala Leu Ser Thr Asp Leu Gly Val Tyr
            100                 105                 110         
Thr Cys Glu Ala Ser Asn Arg Leu Gly Thr Ala Val Ser Arg Gly Ala
        115                 120                 125             
Arg Leu Ser Val Ala Val Leu Arg Glu Asp Phe Gln Ile Gln Pro Arg
    130                 135                 140                 
Asp Met Val Ala Val Val Gly Glu Gln Phe Thr Leu Glu Cys Gly Pro
145                 150                 155                 160 
Pro Trp Gly His Pro Glu Pro Thr Val Ser Trp Trp Lys Asp Glu Lys
                165                 170                 175     
Pro Leu Ala Leu Gln Pro Gly Arg His Thr Val Ser Gly Gly Ser Leu
            180                 185                 190         
Leu Met Ala Arg Ala Glu Lys Ser Asp Glu Gly Thr Tyr Met Cys Val
        195                 200                 205             
Ala Thr Asn Ser Ala Gly His Arg Glu Ser Arg Ala Ala Arg Val Ser
    210                 215                 220                 
Ile Gln Glu Pro Gln Asp Tyr Thr Glu Pro Val Glu Leu Leu Ala Val
225                 230                 235                 240 
Arg Ile Gln Leu Glu Asn Val Thr Leu Leu Asn Pro Asp Pro Ala Glu
                245                 250                 255     
Gly Pro Lys Pro Arg Pro Ala Val Trp Leu Ser Trp Lys Val Ser Gly
            260                 265                 270         
Pro Ala Ala Pro Ala Gln Ser Tyr Thr Ala Leu Phe Arg Thr Gln Thr
        275                 280                 285             
Ala Pro Gly Gly Gln Gly Ala Pro Trp Ala Glu Glu Leu Leu Ala Gly
    290                 295                 300                 
Trp Gln Ser Ala Glu Leu Gly Gly Leu His Trp Gly Gln Asp Tyr Glu
305                 310                 315                 320 
Phe Lys Val Arg Pro Ser Ser Gly Arg Ala Arg Gly Pro Asp Ser Asn
                325                 330                 335     
Val Leu Leu Leu Arg Leu Pro Glu Lys Val Pro Ser Ala Pro Pro Gln
            340                 345                 350         
Glu Val Thr Leu Lys Pro Gly Asn Gly Thr Val Phe Val Ser Trp Val
        355                 360                 365             
Pro Pro Pro Ala Glu Asn His Asn Gly Ile Ile Arg Gly Tyr Gln Val
    370                 375                 380                 
Trp Ser Leu Gly Asn Thr Ser Leu Pro Pro Ala Asn Trp Thr Val Val
385                 390                 395                 400 
Gly Glu Gln Thr Gln Leu Glu Ile Ala Thr His Met Pro Gly Ser Tyr
                405                 410                 415     
Cys Val Gln Val Ala Ala Val Thr Gly Ala Gly Ala Gly Glu Pro Ser
            420                 425                 430         
Arg Pro Val Cys Leu Leu Leu Glu Gln Ala Met Glu Arg Ala Thr Gln
        435                 440                 445             
Glu Pro Ser Glu His Gly Pro Trp Thr Leu Glu Gln Leu Arg Ala Thr
    450                 455                 460                 
Leu Lys Arg Pro Glu Val Ile Ala Thr Cys Gly Val Ala Leu Trp Leu
465                 470                 475                 480 
Leu Leu Leu Gly Thr Ala Val Cys Ile His Arg Arg Arg Arg Ala Arg
                485                 490                 495     
Val His Leu Gly Pro Gly Leu Tyr Arg Tyr Thr Ser Glu Asp Ala Ile
            500                 505                 510         
Leu Lys His Arg Met Asp His Ser Asp Ser Gln Trp Leu Ala Asp Thr
        515                 520                 525             
Trp Arg Ser Thr Ser Gly Ser Arg Asp Leu Ser Ser Ser Ser Ser Leu
    530                 535                 540                 
Ser Ser Arg Leu Gly Ala Asp Ala Arg Asp Pro Leu Asp Cys Arg Arg
545                 550                 555                 560 
Ser Leu Leu Ser Trp Asp Ser Arg Ser Pro Gly Val Pro Leu Leu Pro
                565                 570                 575     
Asp Thr Ser Thr Phe Tyr Gly Ser Leu Ile Ala Glu Leu Pro Ser Ser
            580                 585                 590         
Thr Pro Ala Arg Pro Ser Pro Gln Val Pro Ala Val Arg Arg Leu Pro
        595                 600                 605             
Pro Gln Leu Ala Gln Leu Ser Ser Pro Cys Ser Ser Ser Asp Ser Leu
    610                 615                 620                 
Cys Ser Arg Arg Gly Leu Ser Ser Pro Arg Leu Ser Leu Ala Pro Ala
625                 630                 635                 640 
Glu Ala Trp Lys Ala Lys Lys Lys Gln Glu Leu Pro His Ala Asn Ser
                645                 650                 655     
Ser Pro Leu Leu Arg Gly Ser His Ser Leu Glu Leu Arg Ala Cys Glu
            660                 665                 670         
Leu Gly Asn Arg Gly Ser Lys Asn Leu Ser Gln Ser Pro Gly Ala Val
        675                 680                 685             
Pro Gln Ala Leu Val Ala Trp Arg Ala Leu Gly Pro Lys Leu Leu Ser
    690                 695                 700                 
Ser Gln Met Ser Trp Leu Leu Val Ile Ser Leu Gln His Pro Ser Phe
705                 710                 715                 720 
Leu Met Lys Leu Pro Gln Leu Arg Val Asn Arg Pro Ser Leu Arg Trp
                725                 730                 735     
His His Arg Leu Pro Pro Pro Ser Cys Cys Gln Gln Pro Pro Ser Pro
            740                 745                 750         
Ser Leu Ala Pro Ala Val Pro Leu Ala Pro Arg Pro Leu Pro Ser Leu
        755                 760                 765             
Ala Pro Ala Gln Leu Pro Val Ala Cys Pro Ala Pro His Cys His Pro
    770                 775                 780                 
Trp Gly Arg Ile Lys Thr Ala Cys
785                 790         


<210> 8959
<211> 1749
<212> PRT
<213> Homo sapiens

<400> 8959
Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp Leu Pro Leu
 1               5                  10                  15      
His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp Leu Leu Ser
            20                  25                  30          
Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro Arg Gln Val
        35                  40                  45              
Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile
    50                  55                  60                  
Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu
65                  70                  75                  80  
Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ser Thr Ile
                85                  90                  95      
Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val Val Leu Ser
            100                 105                 110         
Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu
        115                 120                 125             
Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe
    130                 135                 140                 
Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr
145                 150                 155                 160 
Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile
                165                 170                 175     
Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn
            180                 185                 190         
Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu
        195                 200                 205             
Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp
    210                 215                 220                 
Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val
225                 230                 235                 240 
Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln
                245                 250                 255     
Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val
            260                 265                 270         
Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg
        275                 280                 285             
Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu
    290                 295                 300                 
Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser
305                 310                 315                 320 
Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu Thr Gly Arg
                325                 330                 335     
Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val
            340                 345                 350         
Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp
        355                 360                 365             
Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp
    370                 375                 380                 
Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly
385                 390                 395                 400 
Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys Val Pro Asn
                405                 410                 415     
Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro
            420                 425                 430         
Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly Ala Pro Pro
        435                 440                 445             
Gly Ala Ala Val Gln Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe
    450                 455                 460                 
Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln Gln Val Tyr
465                 470                 475                 480 
Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr Val Ser Gly
                485                 490                 495     
Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr
            500                 505                 510         
Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His
        515                 520                 525             
Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp Arg Glu Leu
    530                 535                 540                 
Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His
545                 550                 555                 560 
Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu Asp Val Asn
                565                 570                 575     
Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp Val Ser Val
            580                 585                 590         
Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu Arg Ala Thr
        595                 600                 605             
Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu
    610                 615                 620                 
Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val Ser Gly Arg
625                 630                 635                 640 
Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Ser
                645                 650                 655     
Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Met
            660                 665                 670         
Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val
        675                 680                 685             
Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn Glu Pro Gly
    690                 695                 700                 
Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp Leu Gly Thr
705                 710                 715                 720 
Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe
                725                 730                 735     
Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met Ala Leu Asp
            740                 745                 750         
Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala Thr Asp Gly
        755                 760                 765             
Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile Thr Val Leu
    770                 775                 780                 
Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala Tyr Ser Phe
785                 790                 795                 800 
Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser
                805                 810                 815     
Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu Ile Thr Thr
            820                 825                 830         
Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr Gly Gln Leu
        835                 840                 845             
Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu
    850                 855                 860                 
Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr Met Val Asn
865                 870                 875                 880 
Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe Leu Gln Ala
                885                 890                 895     
Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly His Ser Ile
            900                 905                 910         
Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Met Val
        915                 920                 925             
Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala Ile Asn Glu
    930                 935                 940                 
Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val His Ala Gly
945                 950                 955                 960 
Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val Pro Gln Leu
                965                 970                 975     
Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val Asn Asp Asn
            980                 985                 990         
Ser Pro Val Phe Asp Gln Leu Ser Tyr Glu Val Thr Leu Ser Glu Ser
        995                 1000                1005            
Glu Pro Val Asn Ser Arg Phe Phe Lys Val Gln Ala Ser Asp Lys Asp
    1010                1015                1020                
Ser Gly Ala Asn Gly Glu Ile Ala Tyr Thr Ile Ala Glu Gly Asn Thr
1025                1030                1035                1040
Gly Asp Ala Phe Gly Ile Phe Pro Asp Gly Gln Leu Tyr Ile Lys Ser
                1045                1050                1055    
Glu Leu Asp Arg Glu Leu Gln Asp Arg Tyr Val Leu Met Val Val Ala
            1060                1065                1070        
Ser Asp Arg Ala Val Glu Pro Leu Ser Ala Thr Val Asn Val Thr Val
        1075                1080                1085            
Ile Leu Glu Asp Val Asn Asp Asn Arg Pro Leu Phe Asn Ser Thr Asn
    1090                1095                1100                
Tyr Thr Phe Tyr Phe Glu Glu Glu Gln Arg Ala Gly Ser Phe Val Gly
1105                1110                1115                1120
Lys Val Ser Ala Val Asp Lys Asp Phe Gly Pro Asn Gly Glu Val Arg
                1125                1130                1135    
Tyr Ser Phe Glu Met Val Gln Pro Asp Phe Glu Leu His Ala Ile Ser
            1140                1145                1150        
Gly Glu Ile Thr Asn Thr His Gln Phe Asp Arg Glu Ser Leu Met Arg
        1155                1160                1165            
Arg Arg Gly Thr Ala Val Phe Ser Phe Thr Val Ile Ala Thr Asp Gln
    1170                1175                1180                
Gly Ile Pro Gln Pro Leu Lys Asp Gln Ala Thr Val His Val Tyr Met
1185                1190                1195                1200
Lys Asp Ile Asn Asp Asn Ala Pro Lys Phe Leu Lys Asp Phe Tyr Gln
                1205                1210                1215    
Ala Thr Ile Ser Glu Ser Ala Ala Asn Leu Thr Gln Val Leu Arg Val
            1220                1225                1230        
Ser Ala Ser Asp Val Asp Glu Gly Asn Asn Gly Leu Ile His Tyr Ser
        1235                1240                1245            
Ile Ile Lys Gly Asn Glu Glu Arg Gln Phe Ala Ile Asp Ser Thr Ser
    1250                1255                1260                
Gly Gln Val Thr Leu Ile Gly Lys Leu Asp Tyr Glu Ala Thr Pro Ala
1265                1270                1275                1280
Tyr Ser Leu Val Ile Gln Ala Val Asp Ser Gly Thr Ile Pro Leu Asn
                1285                1290                1295    
Ser Thr Cys Thr Leu Asn Ile Asp Ile Leu Asp Glu Asn Asp Asn Thr
            1300                1305                1310        
Pro Ser Phe Pro Lys Ser Thr Leu Phe Val Asp Val Leu Glu Asn Met
        1315                1320                1325            
Arg Ile Gly Glu Leu Val Ser Ser Val Thr Ala Thr Asp Ser Asp Ser
    1330                1335                1340                
Gly Asp Asn Ala Asp Leu Tyr Tyr Ser Ile Thr Gly Thr Asn Asn His
1345                1350                1355                1360
Gly Thr Phe Ser Ile Ser Pro Asn Thr Gly Ser Ile Phe Leu Ala Lys
                1365                1370                1375    
Lys Leu Asp Phe Glu Thr Gln Ser Leu Tyr Lys Leu Asn Ile Thr Ala
            1380                1385                1390        
Lys Asp Gln Gly Arg Pro Pro Arg Ser Ser Thr Met Ser Val Val Ile
        1395                1400                1405            
His Val Arg Asp Phe Asn Asp Asn Pro Pro Ser Phe Pro Pro Gly Asp
    1410                1415                1420                
Ile Phe Lys Ser Ile Val Glu Asn Ile Pro Ile Gly Thr Ser Val Ile
1425                1430                1435                1440
Ser Val Thr Ala His Asp Pro Asp Ala Asp Ile Asn Gly Gln Leu Ser
                1445                1450                1455    
Tyr Thr Ile Ile Gln Gln Met Pro Arg Gly Asn His Phe Thr Ile Asp
            1460                1465                1470        
Glu Val Lys Gly Thr Ile Tyr Thr Asn Ala Glu Ile Asp Arg Glu Phe
        1475                1480                1485            
Ala Asn Leu Phe Glu Leu Thr Val Lys Ala Asn Asp Gln Ala Val Pro
    1490                1495                1500                
Ile Glu Thr Arg Arg Tyr Ala Leu Lys Asn Val Thr Ile Leu Val Thr
1505                1510                1515                1520
Asp Leu Asn Asp Asn Val Pro Met Phe Ile Ser Gln Asn Ala Leu Ala
                1525                1530                1535    
Ala Asp Pro Ser Ala Val Ile Gly Ser Val Leu Thr Thr Ile Met Ala
            1540                1545                1550        
Ala Asp Pro Asp Glu Gly Ala Asn Gly Glu Ile Glu Tyr Glu Ile Ile
        1555                1560                1565            
Asn Gly Asp Thr Asp Thr Phe Ile Val Asp Arg Tyr Ser Gly Asp Leu
    1570                1575                1580                
Arg Val Ala Ser Ala Leu Val Pro Ser Gln Leu Ile Tyr Asn Leu Ile
1585                1590                1595                1600
Val Ser Ala Thr Asp Leu Gly Pro Glu Arg Arg Lys Ser Thr Thr Glu
                1605                1610                1615    
Leu Thr Ile Ile Leu Gln Gly Leu Asp Gly Pro Val Phe Thr Gln Pro
            1620                1625                1630        
Lys Tyr Ile Thr Ile Leu Lys Glu Gly Glu Pro Ile Gly Thr Asn Val
        1635                1640                1645            
Ile Ser Ile Glu Ala Ala Ser Pro Arg Gly Ser Glu Ala Pro Val Glu
    1650                1655                1660                
Tyr Tyr Ile Val Ser Val Arg Cys Glu Glu Lys Thr Val Gly Arg Leu
1665                1670                1675                1680
Phe Thr Ile Gly Arg His Thr Gly Ile Ile Gln Thr Ala Ala Ile Leu
                1685                1690                1695    
Asp Arg Glu Gln Gly Ala Cys Leu Tyr Leu Val Asp Val Tyr Ala Ile
            1700                1705                1710        
Glu Lys Ser Thr Ala Phe Pro Arg Thr Gln Arg Ala Glu Ala Pro Gln
        1715                1720                1725            
Arg His Ser Ser Val Ser Gln Pro Lys Thr Gln Thr Ser Asn Val Val
    1730                1735                1740                
Cys Asp Thr Trp Gln
1745                


<210> 8960
<211> 761
<212> PRT
<213> Homo sapiens

<400> 8960
Ser Gln Leu Leu Arg Val Phe Trp Leu Leu Ser Leu Leu Pro Gly Gln
 1               5                  10                  15      
Ala Trp Val His Gly Ala Glu Pro Arg Gln Val Phe Gln Val Leu Glu
            20                  25                  30          
Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile Gln Thr Arg Pro Gly
        35                  40                  45              
Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu Phe Ala Ile Asn Ser
    50                  55                  60                  
Ser Thr Gly Ala Leu Tyr Thr Thr Ser Thr Ile Asp Arg Glu Ser Leu
65                  70                  75                  80  
Pro Ser Asp Val Ile Asn Leu Val Val Leu Ser Ser Ala Pro Thr Tyr
                85                  90                  95      
Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu Asn Asp Asn Ala Pro
            100                 105                 110         
Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe Lys Glu Asp Ser Ser
        115                 120                 125             
Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr Asp Ser Asp Ile Gly
    130                 135                 140                 
Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile Ile Arg Gly Asn Glu
145                 150                 155                 160 
Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn Pro Ser Gly Glu Gly
                165                 170                 175     
Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu Asp Arg Glu Val Thr
            180                 185                 190         
Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp Lys Gly Glu Pro Lys
        195                 200                 205             
Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val Gln Asp Ile Asn Asp
    210                 215                 220                 
Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln Ala Gly Val Pro Glu
225                 230                 235                 240 
Asp Ala Val Val Gly Ser Ser Val Leu Gln Val Ala Ala Ala Asp Ala
                245                 250                 255     
Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg Leu Gln Asp Glu Gly
            260                 265                 270         
Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu Ile Thr Val Arg Glu
        275                 280                 285             
Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser Leu Thr Val Gln Ala
    290                 295                 300                 
Met Asp Arg Gly Val Pro Ser Leu Thr Gly Arg Ala Glu Ala Leu Ile
305                 310                 315                 320 
Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val Val Lys Phe Arg Tyr
                325                 330                 335     
Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp Glu Asn Ala Gln Val
            340                 345                 350         
Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp Ala Asp Ser Pro Ala
        355                 360                 365             
Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly Gly Asn Glu Gln Arg
    370                 375                 380                 
His Phe Glu Val Gln Ser Ser Lys Val Pro Asn Leu Ser Leu Ile Lys
385                 390                 395                 400 
Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro Ser Tyr Asn Leu Thr
                405                 410                 415     
Val Ser Val Ser Asp Asn Tyr Gly Ala Pro Pro Gly Ala Ala Val Gln
            420                 425                 430         
Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe Val Asn Asp Ile Asn
        435                 440                 445             
Asp His Pro Pro Val Phe Ser Gln Gln Val Tyr Arg Val Asn Leu Ser
    450                 455                 460                 
Glu Glu Ala Pro Pro Gly Ser Tyr Val Ser Gly Ile Ser Ala Thr Asp
465                 470                 475                 480 
Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr Ser Ile Val Ser Gly
                485                 490                 495     
Asn Gly Leu Gly Trp Ser Arg Phe Gln Val Asn Ala Gln Ser Gly Val
            500                 505                 510         
Ile Ser Thr Arg Met Ala Leu Asp Arg Glu Glu Lys Thr Ala Tyr Gln
        515                 520                 525             
Leu Gln Ile Val Ala Thr Asp Gly Gly Asn Leu Gln Ser Pro Asn Gln
    530                 535                 540                 
Ala Ile Val Thr Ile Thr Val Leu Asp Thr Gln Asp Asn Pro Pro Val
545                 550                 555                 560 
Phe Ser Gln Val Ala Tyr Ser Phe Val Val Phe Glu Asn Val Ala Leu
                565                 570                 575     
Gly Tyr His Val Gly Ser Val Ser Ala Ser Thr Met Asp Leu Asn Ser
            580                 585                 590         
Asn Ile Ser Tyr Leu Ile Thr Thr Gly Asp Gln Lys Gly Met Phe Ala
        595                 600                 605             
Ile Asn Gln Val Thr Gly Gln Leu Thr Thr Ala Asn Val Ile Asp Arg
    610                 615                 620                 
Glu Glu Gln Ser Phe Tyr Gln Leu Lys Val Val Ala Met Asp Ser Gly
625                 630                 635                 640 
Thr Ile Pro Leu Asn Ser Thr Cys Thr Leu Asn Ile Asp Ile Leu Asp
                645                 650                 655     
Glu Asn Asp Asn Thr Pro Ser Phe Pro Lys Ser Thr Leu Phe Val Asp
            660                 665                 670         
Val Leu Glu Asn Met Arg Ile Gly Glu Leu Val Ser Ser Val Thr Ala
        675                 680                 685             
Thr Asp Ser Asp Ser Gly Asp Asn Ala Asp Leu Tyr Tyr Ser Ile Thr
    690                 695                 700                 
Gly Thr Asn Asn His Gly Thr Phe Ser Ile Ser Pro Asn Thr Gly Ser
705                 710                 715                 720 
Ile Phe Leu Ala Lys Lys Leu Asp Phe Glu Thr Gln Ser Leu Tyr Lys
                725                 730                 735     
Leu Asn Ile Thr Ala Lys Asp Gln Gly Arg Pro Pro Arg Ser Ser Thr
            740                 745                 750         
Met Ser Val Val Ile His Val Arg Asp
        755                 760     


<210> 8961
<211> 771
<212> PRT
<213> Homo sapiens

<400> 8961
Met Ser Gly Arg Ser Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu
 1               5                  10                  15      
Ser Glu Leu Glu Arg Ala Arg Leu Gln Glu Val Pro Phe Tyr Gln Leu
            20                  25                  30          
Gln Gln Asp Cys Asp Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly
        35                  40                  45              
Gln Lys Arg Lys Lys Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys
    50                  55                  60                  
Glu Lys Asn Lys Asp Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro
65                  70                  75                  80  
Leu Ser Gln Val Ile Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp
                85                  90                  95      
Leu Gln Arg Asp Glu Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu
            100                 105                 110         
Leu Pro Phe Gly Asn Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn
        115                 120                 125             
Ser Ser Leu Ser Ser Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro
    130                 135                 140                 
Asn Thr Pro Glu Pro Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser
145                 150                 155                 160 
Val Asp Ser Ile Thr Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu
                165                 170                 175     
Ala Leu Gln Leu Ser Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys
            180                 185                 190         
Ala Arg Asp Lys Lys Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro
        195                 200                 205             
Arg Leu Val Asp Ser Cys Cys Gln His Leu Glu Lys His Gly Leu Gln
    210                 215                 220                 
Thr Val Gly Ile Phe Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln
225                 230                 235                 240 
Leu Arg Glu Glu Phe Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu
                245                 250                 255     
His Ser Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp
            260                 265                 270         
Met Pro Asp Pro Leu Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn
        275                 280                 285             
Thr Leu Leu Leu Glu Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu
    290                 295                 300                 
Ile Tyr Leu Leu Pro Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu
305                 310                 315                 320 
Gln Phe Leu Ser Ile Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys
                325                 330                 335     
Asp Gly Gln Glu Val Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala
            340                 345                 350         
Thr Ile Phe Gly Pro Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys
        355                 360                 365             
Glu Phe Ser Val Gln Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile
    370                 375                 380                 
Ile Ala Val Val Gln Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met
385                 390                 395                 400 
Val Pro Pro Asp Leu Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr
                405                 410                 415     
Asp Pro Asp Val Val Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser
            420                 425                 430         
Ser Ser Pro Asp Met Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly
        435                 440                 445             
Arg His Ser Ser Thr Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser
    450                 455                 460                 
Pro Tyr Asp Asn Asn Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala
465                 470                 475                 480 
Met Gln Glu Asp Ala Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val
                485                 490                 495     
Pro Gly Gln Phe Met Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg
            500                 505                 510         
Glu Ser Ser Pro Gly Pro Arg Leu Gly Lys Asp Leu Ser Glu Glu Pro
        515                 520                 525             
Phe Asp Ile Trp Gly Thr Trp His Ser Thr Leu Lys Ser Gly Ser Lys
    530                 535                 540                 
Asp Pro Gly Met Thr Gly Ser Ser Gly Asp Ile Phe Glu Ser Ser Ser
545                 550                 555                 560 
Leu Arg Ala Gly Pro Cys Ser Leu Ser Gln Gly Asn Leu Ser Pro Asn
                565                 570                 575     
Trp Pro Arg Trp Gln Gly Ser Pro Ala Glu Leu Asp Ser Asp Thr Gln
            580                 585                 590         
Gly Ala Arg Arg Thr Gln Ala Ala Ala Pro Ala Thr Glu Gly Arg Ala
        595                 600                 605             
His Pro Ala Val Ser Arg Ala Cys Ser Thr Pro His Val Gln Val Ala
    610                 615                 620                 
Gly Lys Ala Glu Arg Pro Thr Ala Arg Ser Glu Gln Tyr Leu Thr Leu
625                 630                 635                 640 
Ser Gly Ala His Asp Leu Ser Glu Ser Glu Leu Asp Val Ala Gly Leu
                645                 650                 655     
Gln Ser Arg Ala Thr Pro Gln Cys Gln Arg Pro His Gly Ser Gly Arg
            660                 665                 670         
Asp Asp Lys Arg Pro Pro Pro Pro Tyr Pro Gly Pro Gly Lys Pro Ala
        675                 680                 685             
Ala Ala Ala Ala Trp Ile Gln Gly Pro Pro Glu Gly Val Glu Thr Pro
    690                 695                 700                 
Thr Asp Gln Gly Gly Gln Ala Ala Glu Arg Glu Gln Gln Val Thr Gln
705                 710                 715                 720 
Lys Lys Leu Ser Ser Ala Asn Ser Leu Pro Ala Gly Glu Gln Asp Ser
                725                 730                 735     
Pro Arg Leu Gly Asp Ala Gly Trp Leu Asp Trp Gln Arg Glu Arg Trp
            740                 745                 750         
Gln Ile Trp Glu Leu Leu Ser Thr Asp Asn Pro Asp Ala Leu Pro Glu
        755                 760                 765             
Thr Leu Val
    770     


<210> 8962
<211> 562
<212> PRT
<213> Homo sapiens

<400> 8962
Met Ser Gly Arg Ser Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu
 1               5                  10                  15      
Ser Glu Leu Glu Arg Ala Arg Leu Gln Glu Val Pro Phe Tyr Gln Leu
            20                  25                  30          
Gln Gln Asp Cys Asp Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly
        35                  40                  45              
Gln Lys Arg Lys Lys Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys
    50                  55                  60                  
Glu Lys Asn Lys Asp Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro
65                  70                  75                  80  
Leu Ser Gln Val Ile Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp
                85                  90                  95      
Leu Gln Arg Asp Glu Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu
            100                 105                 110         
Leu Pro Phe Gly Asn Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn
        115                 120                 125             
Ser Ser Leu Ser Ser Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro
    130                 135                 140                 
Asn Thr Pro Glu Pro Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser
145                 150                 155                 160 
Val Asp Ser Ile Thr Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu
                165                 170                 175     
Ala Leu Gln Leu Ser Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys
            180                 185                 190         
Ala Arg Asp Lys Lys Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro
        195                 200                 205             
Arg Leu Val Asp Ser Cys Cys Gln His Leu Glu Lys His Gly Leu Gln
    210                 215                 220                 
Thr Val Gly Ile Phe Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln
225                 230                 235                 240 
Leu Arg Glu Glu Phe Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu
                245                 250                 255     
His Ser Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp
            260                 265                 270         
Met Pro Asp Pro Leu Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn
        275                 280                 285             
Thr Leu Leu Leu Glu Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu
    290                 295                 300                 
Ile Tyr Leu Leu Pro Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu
305                 310                 315                 320 
Gln Phe Leu Ser Ile Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys
                325                 330                 335     
Asp Gly Gln Glu Val Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala
            340                 345                 350         
Thr Ile Phe Gly Pro Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys
        355                 360                 365             
Glu Phe Ser Val Gln Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile
    370                 375                 380                 
Ile Ala Val Val Gln Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met
385                 390                 395                 400 
Val Pro Pro Asp Leu Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr
                405                 410                 415     
Asp Pro Asp Val Val Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser
            420                 425                 430         
Ser Ser Pro Asp Met Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly
        435                 440                 445             
Arg His Ser Ser Thr Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser
    450                 455                 460                 
Pro Tyr Asp Asn Asn Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala
465                 470                 475                 480 
Met Gln Glu Asp Ala Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val
                485                 490                 495     
Pro Gly Gln Phe Met Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg
            500                 505                 510         
Glu Ser Ser Pro Gly Pro Arg Leu Gly Lys Gly Asn Trp Ser Leu Ala
        515                 520                 525             
Ser Arg Arg Trp Pro Lys Gln Ala Thr Leu Leu Leu Leu His Val Ala
    530                 535                 540                 
Trp Cys Gly Ala Leu Arg Thr Phe Ser Ser Ser Leu Pro Tyr Leu Met
545                 550                 555                 560 
Phe Leu
        


<210> 8963
<211> 765
<212> PRT
<213> Homo sapiens

<400> 8963
Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro
 1               5                  10                  15      
Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu
            20                  25                  30          
Arg Gln Thr Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser
        35                  40                  45              
Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Thr Ala Gly Arg
    50                  55                  60                  
Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala
65                  70                  75                  80  
Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Thr Arg Leu Pro Pro Pro
                85                  90                  95      
Gly Pro Leu Cys Ser Ser Phe Ser Thr Pro Ser Thr Pro Gln Glu Lys
            100                 105                 110         
Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg
        115                 120                 125             
Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala
    130                 135                 140                 
Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly
145                 150                 155                 160 
Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln
                165                 170                 175     
Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val
            180                 185                 190         
Trp Lys Ser Glu Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser
        195                 200                 205             
Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg
    210                 215                 220                 
Ala Arg Leu Gln Glu Val Pro Phe Tyr Gln Leu Gln Gln Asp Cys Asp
225                 230                 235                 240 
Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys
                245                 250                 255     
Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp
            260                 265                 270         
Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile
        275                 280                 285             
Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu
    290                 295                 300                 
Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn
305                 310                 315                 320 
Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser
                325                 330                 335     
Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro
            340                 345                 350         
Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr
        355                 360                 365             
Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser
    370                 375                 380                 
Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys
385                 390                 395                 400 
Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser
                405                 410                 415     
Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe
            420                 425                 430         
Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe
        435                 440                 445             
Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp
    450                 455                 460                 
Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu
465                 470                 475                 480 
Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu
                485                 490                 495     
Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro
            500                 505                 510         
Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile
        515                 520                 525             
Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val
    530                 535                 540                 
Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro
545                 550                 555                 560 
Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln
                565                 570                 575     
Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln
            580                 585                 590         
Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu
        595                 600                 605             
Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val
    610                 615                 620                 
Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met
625                 630                 635                 640 
Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Thr
                645                 650                 655     
Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn
            660                 665                 670         
Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala
        675                 680                 685             
Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met
    690                 695                 700                 
Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly
705                 710                 715                 720 
Pro Arg Leu Gly Lys Gly Asn Trp Ser Leu Ala Ser Arg Arg Trp Pro
                725                 730                 735     
Lys Gln Ala Thr Leu Leu Leu Leu His Val Ala Trp Cys Gly Ala Leu
            740                 745                 750         
Arg Thr Phe Ser Ser Ser Leu Pro Tyr Leu Met Phe Leu
        755                 760                 765 


<210> 8964
<211> 974
<212> PRT
<213> Homo sapiens

<400> 8964
Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro
 1               5                  10                  15      
Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu
            20                  25                  30          
Arg Gln Thr Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser
        35                  40                  45              
Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Thr Ala Gly Arg
    50                  55                  60                  
Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala
65                  70                  75                  80  
Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Thr Arg Leu Pro Pro Pro
                85                  90                  95      
Gly Pro Leu Cys Ser Ser Phe Ser Thr Pro Ser Thr Pro Gln Glu Lys
            100                 105                 110         
Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg
        115                 120                 125             
Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala
    130                 135                 140                 
Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly
145                 150                 155                 160 
Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln
                165                 170                 175     
Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val
            180                 185                 190         
Trp Lys Ser Glu Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser
        195                 200                 205             
Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg
    210                 215                 220                 
Ala Arg Leu Gln Glu Val Pro Phe Tyr Gln Leu Gln Gln Asp Cys Asp
225                 230                 235                 240 
Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys
                245                 250                 255     
Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp
            260                 265                 270         
Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile
        275                 280                 285             
Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu
    290                 295                 300                 
Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn
305                 310                 315                 320 
Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser
                325                 330                 335     
Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro
            340                 345                 350         
Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr
        355                 360                 365             
Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser
    370                 375                 380                 
Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys
385                 390                 395                 400 
Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser
                405                 410                 415     
Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe
            420                 425                 430         
Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe
        435                 440                 445             
Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp
    450                 455                 460                 
Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu
465                 470                 475                 480 
Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu
                485                 490                 495     
Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro
            500                 505                 510         
Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile
        515                 520                 525             
Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val
    530                 535                 540                 
Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro
545                 550                 555                 560 
Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln
                565                 570                 575     
Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln
            580                 585                 590         
Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu
        595                 600                 605             
Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val
    610                 615                 620                 
Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met
625                 630                 635                 640 
Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Thr
                645                 650                 655     
Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn
            660                 665                 670         
Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala
        675                 680                 685             
Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met
    690                 695                 700                 
Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly
705                 710                 715                 720 
Pro Arg Leu Gly Lys Asp Leu Ser Glu Glu Pro Phe Asp Ile Trp Gly
                725                 730                 735     
Thr Trp His Ser Thr Leu Lys Ser Gly Ser Lys Asp Pro Gly Met Thr
            740                 745                 750         
Gly Ser Ser Gly Asp Ile Phe Glu Ser Ser Ser Leu Arg Ala Gly Pro
        755                 760                 765             
Cys Ser Leu Ser Gln Gly Asn Leu Ser Pro Asn Trp Pro Arg Trp Gln
    770                 775                 780                 
Gly Ser Pro Ala Glu Leu Asp Ser Asp Thr Gln Gly Ala Arg Arg Thr
785                 790                 795                 800 
Gln Ala Ala Ala Pro Ala Thr Glu Gly Arg Ala His Pro Ala Val Ser
                805                 810                 815     
Arg Ala Cys Ser Thr Pro His Val Gln Val Ala Gly Lys Ala Glu Arg
            820                 825                 830         
Pro Thr Ala Arg Ser Glu Gln Tyr Leu Thr Leu Ser Gly Ala His Asp
        835                 840                 845             
Leu Ser Glu Ser Glu Leu Asp Val Ala Gly Leu Gln Ser Arg Ala Thr
    850                 855                 860                 
Pro Gln Cys Gln Arg Pro His Gly Ser Gly Arg Asp Asp Lys Arg Pro
865                 870                 875                 880 
Pro Pro Pro Tyr Pro Gly Pro Gly Lys Pro Ala Ala Ala Ala Ala Trp
                885                 890                 895     
Ile Gln Gly Pro Pro Glu Gly Val Glu Thr Pro Thr Asp Gln Gly Gly
            900                 905                 910         
Gln Ala Ala Glu Arg Glu Gln Gln Val Thr Gln Lys Lys Leu Ser Ser
        915                 920                 925             
Ala Asn Ser Leu Pro Ala Gly Glu Gln Asp Ser Pro Arg Leu Gly Asp
    930                 935                 940                 
Ala Gly Trp Leu Asp Trp Gln Arg Glu Arg Trp Gln Ile Trp Glu Leu
945                 950                 955                 960 
Leu Ser Thr Asp Asn Pro Asp Ala Leu Pro Glu Thr Leu Val
                965                 970                 


<210> 8965
<211> 522
<212> PRT
<213> Homo sapiens

<400> 8965
Met Ser Leu Arg Val His Thr Leu Pro Thr Leu Leu Gly Ala Val Val
 1               5                  10                  15      
Arg Pro Gly Cys Arg Glu Leu Leu Cys Leu Leu Met Ile Thr Val Thr
            20                  25                  30          
Val Gly Pro Gly Ala Ser Gly Val Cys Pro Thr Ala Cys Ile Cys Ala
        35                  40                  45              
Thr Asp Ile Val Ser Cys Thr Asn Lys Asn Leu Ser Lys Val Pro Gly
    50                  55                  60                  
Asn Leu Phe Arg Leu Ile Lys Arg Leu Asp Leu Ser Tyr Asn Arg Ile
65                  70                  75                  80  
Gly Leu Leu Asp Ser Glu Trp Ile Pro Val Ser Phe Ala Lys Leu Asn
                85                  90                  95      
Thr Leu Ile Leu Arg His Asn Asn Ile Thr Ser Ile Ser Thr Gly Ser
            100                 105                 110         
Phe Ser Thr Thr Pro Asn Leu Lys Cys Leu Asp Leu Ser Ser Asn Lys
        115                 120                 125             
Leu Lys Thr Val Lys Asn Ala Val Phe Gln Glu Leu Lys Val Leu Glu
    130                 135                 140                 
Val Leu Leu Leu Tyr Asn Asn His Ile Ser Tyr Leu Asp Pro Ser Ala
145                 150                 155                 160 
Phe Gly Gly Leu Ser Gln Leu Gln Lys Leu Tyr Leu Ser Gly Asn Phe
                165                 170                 175     
Leu Thr Gln Phe Pro Met Asp Leu Tyr Val Gly Arg Phe Lys Leu Ala
            180                 185                 190         
Glu Leu Met Phe Leu Asp Val Ser Tyr Asn Arg Ile Pro Ser Met Pro
        195                 200                 205             
Met His His Ile Asn Leu Val Pro Gly Lys Gln Leu Arg Gly Ile Tyr
    210                 215                 220                 
Leu His Gly Asn Pro Phe Val Cys Asp Cys Ser Leu Tyr Ser Leu Leu
225                 230                 235                 240 
Val Phe Trp Tyr Arg Arg His Phe Ser Ser Val Met Asp Phe Lys Asn
                245                 250                 255     
Asp Tyr Thr Cys Arg Leu Trp Ser Asp Ser Arg His Ser Arg Gln Val
            260                 265                 270         
Leu Leu Leu Gln Asp Ser Phe Met Asn Cys Ser Asp Ser Ile Ile Asn
        275                 280                 285             
Gly Ser Phe Arg Ala Leu Gly Phe Ile His Glu Ala Gln Val Gly Glu
    290                 295                 300                 
Arg Leu Met Val His Cys Asp Ser Lys Thr Gly Asn Ala Asn Thr Asp
305                 310                 315                 320 
Phe Ile Trp Val Gly Pro Asp Asn Arg Leu Leu Glu Pro Asp Lys Glu
                325                 330                 335     
Met Glu Asn Phe Tyr Val Phe His Asn Gly Ser Leu Val Ile Glu Ser
            340                 345                 350         
Pro Arg Phe Glu Asp Ala Gly Val Tyr Ser Cys Ile Ala Met Asn Lys
        355                 360                 365             
Gln Arg Leu Leu Asn Glu Thr Val Asp Val Thr Ile Asn Val Ser Asn
    370                 375                 380                 
Phe Thr Val Ser Arg Ser His Ala His Glu Ala Phe Asn Thr Ala Phe
385                 390                 395                 400 
Thr Thr Leu Ala Ala Cys Val Ala Ser Ile Val Leu Val Leu Leu Tyr
                405                 410                 415     
Leu Tyr Leu Thr Pro Cys Pro Cys Lys Cys Lys Thr Lys Arg Gln Lys
            420                 425                 430         
Asn Met Leu His Gln Ser Asn Ala His Ser Ser Ile Leu Ser Pro Gly
        435                 440                 445             
Pro Ala Ser Asp Ala Ser Ala Asp Glu Arg Lys Ala Gly Ala Gly Lys
    450                 455                 460                 
Arg Val Val Phe Leu Glu Pro Leu Lys Asp Thr Ala Ala Gly Gln Asn
465                 470                 475                 480 
Gly Lys Val Arg Leu Phe Pro Ser Glu Ala Val Ile Ala Glu Gly Ile
                485                 490                 495     
Leu Lys Ser Thr Arg Gly Lys Ser Asp Ser Asp Ser Val Asn Ser Val
            500                 505                 510         
Phe Ser Asp Thr Pro Phe Val Ala Ser Thr
        515                 520         


<210> 8966
<211> 3695
<212> PRT
<213> Homo sapiens

<400> 8966
Met Ala Lys Arg Leu Cys Ala Gly Ser Ala Leu Cys Val Arg Gly Pro
 1               5                  10                  15      
Arg Gly Pro Ala Pro Leu Leu Leu Val Gly Leu Ala Leu Leu Gly Ala
            20                  25                  30          
Ala Arg Ala Arg Glu Glu Ala Gly Gly Gly Phe Ser Leu His Pro Pro
        35                  40                  45              
Tyr Phe Asn Leu Ala Glu Gly Ala Arg Ile Ala Ala Ser Ala Thr Cys
    50                  55                  60                  
Gly Glu Glu Ala Pro Ala Arg Gly Ser Pro Arg Pro Thr Glu Asp Leu
65                  70                  75                  80  
Tyr Cys Lys Leu Val Gly Gly Pro Val Ala Gly Gly Asp Pro Asn Gln
                85                  90                  95      
Thr Ile Gln Gly Gln Tyr Cys Asp Ile Cys Thr Ala Ala Asn Ser Asn
            100                 105                 110         
Lys Ala His Pro Ala Ser Asn Ala Ile Asp Gly Thr Glu Arg Trp Trp
        115                 120                 125             
Gln Ser Pro Pro Leu Ser Arg Gly Leu Glu Tyr Asn Glu Val Asn Val
    130                 135                 140                 
Thr Leu Asp Leu Gly Gln Val Phe His Val Ala Tyr Val Leu Ile Lys
145                 150                 155                 160 
Phe Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Met
                165                 170                 175     
Asp Phe Gly Arg Thr Tyr Gln Pro Trp Gln Phe Phe Ala Ser Ser Lys
            180                 185                 190         
Arg Asp Cys Leu Glu Arg Phe Gly Pro Gln Thr Leu Glu Arg Ile Thr
        195                 200                 205             
Arg Asp Asp Ala Ala Ile Cys Thr Thr Glu Tyr Ser Arg Ile Val Pro
    210                 215                 220                 
Leu Glu Asn Gly Glu Ile Val Val Ser Leu Val Asn Gly Arg Pro Gly
225                 230                 235                 240 
Ala Met Asn Phe Ser Tyr Ser Pro Leu Leu Arg Glu Phe Thr Lys Ala
                245                 250                 255     
Thr Asn Val Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His
            260                 265                 270         
Leu Met Gly Lys Ala Leu Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr
        275                 280                 285             
Tyr Ser Ile Lys Asp Ile Ser Ile Gly Gly Arg Cys Val Cys His Gly
    290                 295                 300                 
His Ala Asp Ala Cys Asp Ala Lys Asp Pro Thr Asp Pro Phe Arg Leu
305                 310                 315                 320 
Gln Cys Thr Cys Gln His Asn Thr Cys Gly Gly Thr Cys Asp Arg Cys
                325                 330                 335     
Cys Pro Gly Phe Asn Gln Gln Pro Trp Lys Pro Ala Thr Ala Asn Ser
            340                 345                 350         
Ala Asn Glu Cys Gln Ser Cys Asn Cys Tyr Gly His Ala Thr Asp Cys
        355                 360                 365             
Tyr Tyr Asp Pro Glu Val Asp Arg Arg Arg Ala Ser Gln Ser Leu Asp
    370                 375                 380                 
Gly Thr Tyr Gln Gly Gly Gly Val Cys Ile Asp Cys Gln His His Thr
385                 390                 395                 400 
Thr Gly Val Asn Cys Glu Arg Cys Leu Pro Gly Phe Tyr Arg Ser Pro
                405                 410                 415     
Asn His Pro Leu Asp Ser Pro His Val Cys Arg Arg Cys Asn Cys Glu
            420                 425                 430         
Ser Asp Phe Thr Asp Gly Thr Cys Glu Asp Leu Thr Gly Arg Cys Tyr
        435                 440                 445             
Cys Arg Pro Asn Phe Ser Gly Glu Arg Cys Asp Val Cys Ala Glu Gly
    450                 455                 460                 
Phe Thr Gly Phe Pro Ser Cys Tyr Pro Thr Pro Ser Ser Ser Asn Asp
465                 470                 475                 480 
Thr Arg Glu Gln Val Leu Pro Ala Gly Gln Ile Val Asn Cys Asp Cys
                485                 490                 495     
Ser Ala Ala Gly Thr Gln Gly Asn Ala Cys Arg Lys Asp Pro Arg Val
            500                 505                 510         
Gly Arg Cys Leu Cys Lys Pro Asn Phe Gln Gly Thr His Cys Glu Leu
        515                 520                 525             
Cys Ala Pro Gly Phe Tyr Gly Pro Gly Cys Gln Pro Cys Gln Cys Ser
    530                 535                 540                 
Ser Pro Gly Val Ala Asp Asp Arg Cys Asp Pro Asp Thr Gly Gln Cys
545                 550                 555                 560 
Arg Cys Arg Val Gly Phe Glu Gly Ala Thr Cys Asp Arg Cys Ala Pro
                565                 570                 575     
Gly Tyr Phe His Phe Pro Leu Cys Gln Leu Cys Gly Cys Ser Pro Ala
            580                 585                 590         
Gly Thr Leu Pro Glu Gly Cys Asp Glu Ala Gly Arg Cys Leu Cys Gln
        595                 600                 605             
Pro Glu Phe Ala Gly Pro His Cys Asp Arg Cys Arg Pro Gly Tyr His
    610                 615                 620                 
Gly Phe Pro Asn Cys Gln Ala Cys Thr Cys Asp Pro Arg Gly Ala Leu
625                 630                 635                 640 
Asp Gln Leu Cys Gly Ala Gly Gly Leu Cys Arg Cys Arg Pro Gly Tyr
                645                 650                 655     
Thr Gly Thr Ala Cys Gln Glu Cys Ser Pro Gly Phe His Gly Phe Pro
            660                 665                 670         
Ser Cys Val Pro Cys His Cys Ser Ala Glu Gly Ser Leu His Ala Ala
        675                 680                 685             
Cys Asp Pro Arg Ser Gly Gln Cys Ser Cys Arg Pro Arg Val Thr Gly
    690                 695                 700                 
Leu Arg Cys Asp Thr Cys Val Pro Gly Ala Tyr Asn Phe Pro Tyr Cys
705                 710                 715                 720 
Glu Ala Gly Ser Cys His Pro Ala Gly Leu Ala Pro Val Asp Pro Ala
                725                 730                 735     
Leu Pro Glu Ala Gln Val Pro Cys Met Cys Arg Ala His Val Glu Gly
            740                 745                 750         
Pro Ser Cys Asp Arg Cys Lys Pro Gly Phe Trp Gly Leu Ser Pro Ser
        755                 760                 765             
Asn Pro Glu Gly Cys Thr Arg Cys Ser Cys Asp Leu Arg Gly Thr Leu
    770                 775                 780                 
Gly Gly Val Ala Glu Cys Gln Pro Gly Thr Gly Gln Cys Phe Cys Lys
785                 790                 795                 800 
Pro His Val Cys Gly Gln Ala Cys Ala Ser Cys Lys Asp Gly Phe Phe
                805                 810                 815     
Gly Leu Asp Gln Ala Asp Tyr Phe Gly Cys Arg Ser Cys Arg Cys Asp
            820                 825                 830         
Ile Gly Gly Ala Leu Gly Gln Ser Cys Glu Pro Arg Thr Gly Val Cys
        835                 840                 845             
Arg Cys Arg Pro Asn Thr Gln Gly Pro Thr Cys Ser Glu Pro Ala Arg
    850                 855                 860                 
Asp His Tyr Leu Pro Asp Leu His His Leu Arg Leu Glu Leu Glu Glu
865                 870                 875                 880 
Ala Ala Thr Pro Glu Gly His Ala Met Arg Phe Gly Phe Asn Pro Leu
                885                 890                 895     
Glu Phe Glu Asn Phe Ser Trp Arg Gly Tyr Ala Gln Met Ala Pro Val
            900                 905                 910         
Gln Pro Arg Ile Val Ala Arg Leu Asn Leu Thr Ser Pro Asp Leu Phe
        915                 920                 925             
Trp Leu Val Phe Arg Tyr Val Asn Arg Gly Ala Met Ser Val Ser Gly
    930                 935                 940                 
Arg Val Ser Val Arg Glu Glu Gly Arg Ser Ala Thr Cys Ala Asn Cys
945                 950                 955                 960 
Thr Ala Gln Ser Gln Pro Val Ala Phe Pro Pro Ser Thr Glu Pro Ala
                965                 970                 975     
Phe Ile Thr Val Pro Gln Arg Gly Phe Gly Glu Pro Phe Val Leu Asn
            980                 985                 990         
Pro Gly Thr Trp Ala Leu Arg Val Glu Ala Glu Gly Val Leu Leu Asp
        995                 1000                1005            
Tyr Val Val Leu Leu Pro Ser Ala Tyr Tyr Glu Ala Ala Leu Leu Gln
    1010                1015                1020                
Leu Arg Val Thr Glu Ala Cys Thr Tyr Arg Pro Ser Ala Gln Gln Ser
1025                1030                1035                1040
Gly Asp Asn Cys Leu Leu Tyr Thr His Leu Pro Leu Asp Gly Phe Pro
                1045                1050                1055    
Ser Ala Ala Gly Leu Glu Ala Leu Cys Arg Gln Asp Asn Ser Leu Pro
            1060                1065                1070        
Arg Pro Cys Pro Thr Glu Gln Leu Ser Pro Ser His Pro Pro Leu Ile
        1075                1080                1085            
Thr Cys Thr Gly Ser Asp Val Asp Val Gln Leu Gln Val Ala Val Pro
    1090                1095                1100                
Gln Pro Gly Arg Tyr Ala Leu Val Val Glu Tyr Ala Asn Glu Asp Ala
1105                1110                1115                1120
Arg Gln Glu Val Gly Val Ala Val His Thr Pro Gln Arg Ala Pro Gln
                1125                1130                1135    
Gln Gly Leu Leu Ser Leu His Pro Cys Leu Tyr Ser Thr Leu Cys Arg
            1140                1145                1150        
Gly Thr Ala Arg Asp Thr Gln Asp His Leu Ala Val Phe His Leu Asp
        1155                1160                1165            
Ser Glu Ala Ser Val Arg Leu Thr Ala Glu Gln Ala Arg Phe Phe Leu
    1170                1175                1180                
His Gly Val Thr Leu Val Pro Ile Glu Glu Phe Ser Pro Glu Phe Val
1185                1190                1195                1200
Glu Pro Arg Val Ser Cys Ile Ser Ser His Gly Ala Phe Gly Pro Asn
                1205                1210                1215    
Ser Ala Ala Cys Leu Pro Ser Arg Phe Pro Lys Pro Pro Gln Pro Ile
            1220                1225                1230        
Ile Leu Arg Asp Cys Gln Val Ile Pro Leu Pro Pro Gly Leu Pro Leu
        1235                1240                1245            
Thr His Ala Gln Asp Leu Thr Pro Ala Met Ser Pro Ala Gly Pro Arg
    1250                1255                1260                
Pro Arg Pro Pro Thr Ala Val Asp Pro Asp Ala Glu Pro Thr Leu Leu
1265                1270                1275                1280
Arg Glu Pro Gln Ala Thr Val Val Phe Thr Thr His Val Pro Thr Leu
                1285                1290                1295    
Gly Arg Tyr Ala Phe Leu Leu His Gly Tyr Gln Pro Ala His Pro Thr
            1300                1305                1310        
Phe Pro Val Glu Val Leu Ile Asn Ala Gly Arg Val Trp Gln Gly His
        1315                1320                1325            
Ala Asn Ala Ser Phe Cys Pro His Gly Tyr Gly Cys Arg Thr Leu Val
    1330                1335                1340                
Val Cys Glu Gly Gln Ala Leu Leu Asp Val Thr His Ser Glu Leu Thr
1345                1350                1355                1360
Val Thr Val Arg Val Pro Glu Gly Arg Trp Leu Trp Leu Asp Tyr Val
                1365                1370                1375    
Leu Val Val Pro Glu Asn Val Tyr Ser Phe Gly Tyr Leu Arg Glu Glu
            1380                1385                1390        
Pro Leu Asp Lys Ser Tyr Asp Phe Ile Ser His Cys Ala Ala Gln Gly
        1395                1400                1405            
Tyr His Ile Ser Pro Ser Ser Ser Ser Leu Phe Cys Arg Asn Ala Ala
    1410                1415                1420                
Ala Ser Leu Ser Leu Phe Tyr Asn Asn Gly Ala Arg Pro Cys Gly Cys
1425                1430                1435                1440
His Glu Val Gly Ala Thr Gly Pro Thr Cys Glu Pro Phe Gly Gly Gln
                1445                1450                1455    
Cys Pro Cys His Ala His Val Ile Gly Arg Asp Cys Ser Arg Cys Ala
            1460                1465                1470        
Thr Gly Tyr Trp Gly Phe Pro Asn Cys Arg Pro Cys Asp Cys Gly Ala
        1475                1480                1485            
Arg Leu Cys Asp Glu Leu Thr Gly Gln Cys Ile Cys Pro Pro Arg Thr
    1490                1495                1500                
Ile Pro Pro Asp Cys Leu Leu Cys Gln Pro Gln Thr Phe Gly Cys His
1505                1510                1515                1520
Pro Leu Val Gly Cys Glu Glu Cys Asn Cys Ser Gly Pro Gly Ile Gln
                1525                1530                1535    
Glu Leu Thr Asp Pro Thr Cys Asp Thr Asp Ser Gly Gln Cys Lys Cys
            1540                1545                1550        
Arg Pro Asn Val Thr Gly Arg Arg Cys Asp Thr Cys Ser Pro Gly Phe
        1555                1560                1565            
His Gly Tyr Pro Arg Cys Arg Pro Cys Asp Cys His Glu Ala Gly Thr
    1570                1575                1580                
Ala Pro Gly Val Cys Asp Pro Leu Thr Gly Gln Cys Tyr Cys Lys Glu
1585                1590                1595                1600
Asn Val Gln Gly Pro Lys Cys Asp Gln Cys Ser Leu Gly Thr Phe Ser
                1605                1610                1615    
Leu Asp Ala Ala Asn Pro Lys Gly Cys Thr Arg Cys Phe Cys Phe Gly
            1620                1625                1630        
Ala Thr Glu Arg Cys Arg Ser Ser Ser Tyr Thr Arg Gln Glu Phe Val
        1635                1640                1645            
Asp Met Glu Gly Trp Val Leu Leu Ser Thr Asp Arg Gln Val Val Pro
    1650                1655                1660                
His Glu Arg Gln Pro Gly Thr Glu Met Leu Arg Ala Asp Leu Arg His
1665                1670                1675                1680
Val Pro Glu Ala Val Pro Glu Ala Phe Pro Glu Leu Tyr Trp Gln Ala
                1685                1690                1695    
Pro Pro Ser Tyr Leu Gly Asp Arg Val Ser Ser Tyr Gly Gly Thr Leu
            1700                1705                1710        
Arg Tyr Glu Leu His Ser Glu Thr Gln Arg Gly Asp Val Phe Val Pro
        1715                1720                1725            
Met Glu Ser Arg Pro Asp Val Val Leu Gln Gly Asn Gln Met Ser Ile
    1730                1735                1740                
Thr Phe Leu Glu Pro Ala Tyr Pro Thr Pro Gly His Val His Arg Gly
1745                1750                1755                1760
Gln Leu Gln Leu Val Glu Gly Asn Phe Arg His Thr Glu Thr Arg Asn
                1765                1770                1775    
Thr Val Ser Arg Glu Glu Leu Met Met Val Leu Ala Ser Leu Glu Gln
            1780                1785                1790        
Leu Gln Ile Arg Ala Leu Phe Ser Gln Ile Ser Ser Ala Val Ser Leu
        1795                1800                1805            
Arg Arg Val Ala Leu Glu Val Ala Ser Pro Ala Gly Gln Gly Ala Leu
    1810                1815                1820                
Ala Ser Asn Val Glu Leu Cys Leu Cys Pro Ala Ser Tyr Arg Gly Asp
1825                1830                1835                1840
Ser Cys Gln Glu Cys Ala Pro Gly Phe Tyr Arg Asp Val Lys Gly Leu
                1845                1850                1855    
Phe Leu Gly Arg Cys Val Pro Cys Gln Cys His Gly His Ser Asp Arg
            1860                1865                1870        
Cys Leu Pro Gly Ser Gly Val Cys Val Asp Cys Gln His Asn Thr Glu
        1875                1880                1885            
Gly Ala His Cys Glu Arg Cys Gln Ala Gly Phe Val Ser Ser Arg Asp
    1890                1895                1900                
Asp Pro Ser Ala Pro Cys Val Ser Cys Pro Cys Pro Leu Ser Val Pro
1905                1910                1915                1920
Ser Asn Asn Phe Ala Glu Gly Cys Val Leu Arg Gly Gly Arg Thr Gln
                1925                1930                1935    
Cys Leu Cys Lys Pro Gly Tyr Ala Gly Ala Ser Cys Glu Arg Cys Ala
            1940                1945                1950        
Pro Gly Phe Phe Gly Asn Pro Leu Val Leu Gly Ser Ser Cys Gln Pro
        1955                1960                1965            
Cys Asp Cys Ser Gly Asn Gly Asp Pro Asn Leu Leu Phe Ser Asp Cys
    1970                1975                1980                
Asp Pro Leu Thr Gly Ala Cys Arg Gly Cys Leu Arg His Thr Thr Gly
1985                1990                1995                2000
Pro Arg Cys Glu Ile Cys Ala Pro Gly Phe Tyr Gly Asn Ala Leu Leu
                2005                2010                2015    
Pro Gly Asn Cys Thr Arg Cys Asp Cys Thr Pro Cys Gly Thr Glu Ala
            2020                2025                2030        
Cys Asp Pro His Ser Gly His Cys Leu Cys Lys Ala Gly Val Thr Gly
        2035                2040                2045            
Arg Arg Cys Asp Arg Cys Gln Glu Gly His Phe Gly Phe Asn Gly Cys
    2050                2055                2060                
Gly Gly Cys Arg Pro Cys Ala Cys Gly Pro Ala Ala Glu Gly Ser Glu
2065                2070                2075                2080
Cys His Pro Gln Ser Gly Gln Cys His Cys Arg Pro Gly Thr Met Gly
                2085                2090                2095    
Pro Gln Cys Arg Glu Cys Ala Pro Gly Tyr Trp Gly Leu Pro Glu Gln
            2100                2105                2110        
Gly Cys Arg Arg Cys Gln Cys Pro Gly Gly Arg Cys Asp Pro His Thr
        2115                2120                2125            
Gly Arg Cys Asn Cys Pro Pro Gly Leu Ser Gly Glu Arg Cys Asp Thr
    2130                2135                2140                
Cys Ser Gln Gln His Gln Val Pro Val Pro Gly Gly Pro Val Gly His
2145                2150                2155                2160
Ser Ile His Cys Glu Val Cys Asp His Cys Val Val Leu Leu Leu Asp
                2165                2170                2175    
Asp Leu Glu Arg Ala Gly Ala Leu Leu Pro Ala Ile His Glu Gln Leu
            2180                2185                2190        
Arg Gly Ile Asn Ala Ser Ser Met Ala Trp Ala Arg Leu His Arg Leu
        2195                2200                2205            
Asn Ala Ser Ile Ala Asp Leu Gln Ser Gln Leu Arg Ser Pro Leu Gly
    2210                2215                2220                
Pro Arg His Glu Thr Ala Gln Gln Leu Glu Val Leu Glu Gln Gln Ser
2225                2230                2235                2240
Thr Ser Leu Gly Gln Asp Ala Arg Arg Leu Gly Gly Gln Ala Val Gly
                2245                2250                2255    
Thr Arg Asp Gln Ala Ser Gln Leu Leu Ala Gly Thr Glu Ala Thr Leu
            2260                2265                2270        
Gly His Ala Lys Thr Leu Leu Ala Ala Ile Arg Ala Val Asp Arg Thr
        2275                2280                2285            
Leu Ser Glu Leu Met Ser Gln Thr Gly His Leu Gly Leu Ala Asn Ala
    2290                2295                2300                
Ser Ala Pro Ser Gly Glu Gln Leu Leu Arg Thr Leu Ala Glu Val Glu
2305                2310                2315                2320
Arg Leu Leu Trp Glu Met Arg Ala Arg Asp Leu Gly Ala Pro Gln Ala
                2325                2330                2335    
Ala Ala Glu Ala Glu Leu Ala Ala Ala Gln Arg Leu Leu Ala Arg Val
            2340                2345                2350        
Gln Glu Gln Leu Ser Ser Leu Trp Glu Glu Asn Gln Ala Leu Ala Thr
        2355                2360                2365            
Gln Thr Arg Asp Arg Leu Ala Gln His Glu Ala Gly Leu Met Asp Leu
    2370                2375                2380                
Arg Glu Ala Leu Asn Arg Ala Val Asp Ala Thr Arg Glu Ala Gln Glu
2385                2390                2395                2400
Leu Asn Ser Arg Asn Gln Glu Arg Leu Glu Glu Ala Leu Gln Arg Lys
                2405                2410                2415    
Gln Glu Leu Ser Arg Asp Asn Ala Thr Leu Gln Ala Thr Leu His Ala
            2420                2425                2430        
Ala Arg Asp Thr Leu Ala Ser Val Phe Arg Leu Leu His Ser Leu Asp
        2435                2440                2445            
Gln Ala Lys Glu Glu Leu Glu Arg Leu Ala Ala Ser Leu Asp Gly Ala
    2450                2455                2460                
Arg Thr Pro Leu Leu Gln Arg Met Gln Thr Phe Ser Pro Ala Gly Ser
2465                2470                2475                2480
Lys Leu Arg Leu Val Glu Ala Ala Glu Ala His Ala Gln Gln Leu Gly
                2485                2490                2495    
Gln Leu Ala Leu Asn Leu Ser Ser Ile Ile Leu Asp Val Asn Gln Asp
            2500                2505                2510        
Arg Leu Thr Gln Arg Ala Ile Glu Ala Ser Asn Ala Tyr Ser Arg Ile
        2515                2520                2525            
Leu Gln Ala Val Gln Ala Ala Glu Asp Ala Ala Gly Gln Ala Leu Gln
    2530                2535                2540                
Gln Ala Asp His Thr Trp Ala Thr Val Val Arg Gln Gly Leu Val Asp
2545                2550                2555                2560
Arg Ala Gln Gln Leu Leu Ala Asn Ser Thr Ala Leu Glu Glu Ala Met
                2565                2570                2575    
Leu Gln Glu Gln Gln Arg Leu Gly Leu Val Trp Ala Ala Leu Gln Gly
            2580                2585                2590        
Ala Arg Thr Gln Leu Arg Asp Val Arg Ala Lys Lys Asp Gln Leu Glu
        2595                2600                2605            
Ala His Ile Gln Ala Ala Gln Ala Met Leu Ala Met Asp Thr Asp Glu
    2610                2615                2620                
Thr Ser Lys Lys Ile Ala His Ala Lys Ala Val Ala Ala Glu Ala Gln
2625                2630                2635                2640
Asp Thr Ala Thr Arg Val Gln Ser Gln Leu Gln Ala Met Gln Glu Asn
                2645                2650                2655    
Val Glu Arg Trp Gln Gly Gln Tyr Glu Gly Leu Arg Gly Gln Asp Leu
            2660                2665                2670        
Gly Gln Ala Val Leu Asp Ala Gly His Ser Val Ser Thr Leu Glu Lys
        2675                2680                2685            
Thr Leu Pro Gln Leu Leu Ala Lys Leu Ser Ile Leu Glu Asn Arg Gly
    2690                2695                2700                
Val His Asn Ala Ser Leu Ala Leu Ser Ala Ser Ile Gly Arg Val Arg
2705                2710                2715                2720
Glu Leu Ile Ala Gln Ala Arg Gly Ala Ala Ser Lys Val Lys Val Pro
                2725                2730                2735    
Met Lys Phe Asn Gly Arg Ser Gly Val Gln Leu Arg Thr Pro Arg Asp
            2740                2745                2750        
Leu Ala Asp Leu Ala Ala Tyr Thr Ala Leu Lys Phe Tyr Leu Gln Gly
        2755                2760                2765            
Pro Glu Pro Glu Pro Gly Gln Gly Thr Glu Asp Arg Phe Val Met Tyr
    2770                2775                2780                
Met Gly Ser Arg Gln Ala Thr Gly Asp Tyr Met Gly Val Ser Leu Arg
2785                2790                2795                2800
Asp Lys Lys Val His Trp Val Tyr Gln Leu Gly Glu Ala Gly Pro Ala
                2805                2810                2815    
Val Leu Ser Ile Asp Glu Asp Ile Gly Glu Gln Phe Ala Ala Val Ser
            2820                2825                2830        
Leu Asp Arg Thr Leu Gln Phe Gly His Met Ser Val Thr Val Glu Arg
        2835                2840                2845            
Gln Met Ile Gln Glu Thr Lys Gly Asp Thr Val Ala Pro Gly Ala Glu
    2850                2855                2860                
Gly Leu Leu Asn Leu Arg Pro Asp Asp Phe Val Phe Tyr Val Gly Gly
2865                2870                2875                2880
Tyr Pro Ser Thr Phe Thr Pro Pro Pro Leu Leu Arg Phe Pro Gly Tyr
                2885                2890                2895    
Arg Gly Cys Ile Glu Met Asp Thr Leu Asn Glu Glu Val Val Ser Leu
            2900                2905                2910        
Tyr Asn Phe Glu Arg Thr Phe Gln Leu Asp Thr Ala Val Asp Arg Pro
        2915                2920                2925            
Cys Ala Arg Ser Lys Ser Thr Gly Asp Pro Trp Leu Thr Asp Gly Ser
    2930                2935                2940                
Tyr Leu Asp Gly Thr Gly Phe Ala Arg Ile Ser Phe Asp Ser Gln Ile
2945                2950                2955                2960
Ser Thr Thr Lys Arg Phe Glu Gln Glu Leu Arg Leu Val Ser Tyr Ser
                2965                2970                2975    
Gly Val Leu Phe Phe Leu Lys Gln Gln Ser Gln Phe Leu Cys Leu Ala
            2980                2985                2990        
Val Gln Glu Gly Ser Leu Val Leu Leu Tyr Asp Phe Gly Ala Gly Leu
        2995                3000                3005            
Lys Lys Ala Val Pro Leu Gln Pro Pro Pro Pro Leu Thr Ser Ala Ser
    3010                3015                3020                
Lys Ala Ile Gln Val Phe Leu Leu Gly Gly Ser Arg Lys Arg Val Leu
3025                3030                3035                3040
Val Arg Val Glu Arg Ala Thr Val Tyr Ser Val Glu Gln Asp Asn Asp
                3045                3050                3055    
Leu Glu Leu Ala Asp Ala Tyr Tyr Leu Gly Gly Val Pro Pro Asp Gln
            3060                3065                3070        
Leu Pro Pro Ser Leu Arg Trp Leu Phe Pro Thr Gly Gly Ser Val Arg
        3075                3080                3085            
Gly Cys Val Lys Gly Ile Lys Ala Leu Gly Lys Tyr Val Asp Leu Lys
    3090                3095                3100                
Arg Leu Asn Thr Thr Gly Val Ser Ala Gly Cys Thr Ala Asp Leu Leu
3105                3110                3115                3120
Val Gly Arg Ala Met Thr Phe His Gly His Gly Phe Leu Arg Leu Ala
                3125                3130                3135    
Leu Ser Asn Val Ala Pro Leu Thr Gly Asn Val Tyr Ser Gly Phe Gly
            3140                3145                3150        
Phe His Ser Ala Gln Asp Ser Ala Leu Leu Tyr Tyr Arg Ala Ser Pro
        3155                3160                3165            
Asp Gly Leu Cys Gln Val Ser Leu Gln Gln Gly Arg Val Ser Leu Gln
    3170                3175                3180                
Leu Leu Arg Thr Glu Val Lys Thr Gln Ala Gly Phe Ala Asp Gly Ala
3185                3190                3195                3200
Pro His Tyr Val Ala Phe Tyr Ser Asn Ala Thr Gly Val Trp Leu Tyr
                3205                3210                3215    
Val Asp Asp Gln Leu Gln Gln Met Lys Pro His Arg Gly Pro Pro Pro
            3220                3225                3230        
Glu Leu Gln Pro Gln Pro Glu Gly Pro Pro Arg Leu Leu Leu Gly Gly
        3235                3240                3245            
Leu Pro Glu Ser Gly Thr Ile Tyr Asn Phe Ser Gly Cys Ile Ser Asn
    3250                3255                3260                
Val Phe Val Gln Arg Leu Leu Gly Pro Gln Arg Val Phe Asp Leu Gln
3265                3270                3275                3280
Gln Asn Leu Gly Ser Val Asn Val Ser Thr Gly Cys Ala Pro Ala Leu
                3285                3290                3295    
Gln Ala Gln Thr Pro Gly Leu Gly Pro Arg Gly Leu Gln Ala Thr Ala
            3300                3305                3310        
Arg Lys Ala Ser Arg Arg Ser Arg Gln Pro Ala Arg His Pro Ala Cys
        3315                3320                3325            
Met Leu Pro Pro His Leu Arg Thr Thr Arg Asp Ser Tyr Gln Phe Gly
    3330                3335                3340                
Gly Ser Leu Ser Ser His Leu Glu Phe Val Gly Ile Leu Ala Arg His
3345                3350                3355                3360
Arg Asn Trp Pro Ser Leu Ser Met His Val Leu Pro Arg Ser Ser Arg
                3365                3370                3375    
Gly Leu Leu Leu Phe Thr Ala Arg Leu Arg Pro Gly Ser Pro Ser Leu
            3380                3385                3390        
Ala Leu Phe Leu Ser Asn Gly His Phe Val Ala Gln Met Glu Gly Leu
        3395                3400                3405            
Gly Thr Arg Leu Arg Ala Gln Ser Arg Gln Arg Ser Arg Pro Gly Arg
    3410                3415                3420                
Trp His Lys Val Ser Val Arg Trp Glu Lys Asn Arg Ile Leu Leu Val
3425                3430                3435                3440
Thr Asp Gly Ala Arg Ala Trp Ser Gln Glu Gly Pro His Arg Gln His
                3445                3450                3455    
Gln Gly Ala Glu His Pro Gln Pro His Thr Leu Phe Val Gly Gly Leu
            3460                3465                3470        
Pro Ala Ser Ser His Ser Ser Lys Leu Pro Val Thr Val Gly Phe Ser
        3475                3480                3485            
Gly Cys Val Lys Arg Leu Arg Leu His Gly Arg Pro Leu Gly Ala Pro
    3490                3495                3500                
Thr Arg Met Ala Gly Val Thr Pro Cys Ile Leu Gly Pro Leu Glu Ala
3505                3510                3515                3520
Gly Leu Phe Phe Pro Gly Ser Gly Gly Val Ile Thr Leu Asp Leu Pro
                3525                3530                3535    
Gly Ala Thr Leu Pro Asp Val Gly Leu Glu Leu Glu Val Arg Pro Leu
            3540                3545                3550        
Ala Val Thr Gly Leu Ile Phe His Leu Gly Gln Ala Arg Thr Pro Pro
        3555                3560                3565            
Tyr Leu Gln Leu Gln Val Thr Glu Lys Gln Val Leu Leu Arg Ala Asp
    3570                3575                3580                
Asp Gly Ala Gly Glu Phe Ser Thr Ser Val Thr Arg Pro Ser Val Leu
3585                3590                3595                3600
Cys Asp Gly Gln Trp His Arg Leu Ala Val Met Lys Ser Gly Asn Val
                3605                3610                3615    
Leu Arg Leu Glu Val Asp Ala Gln Ser Asn His Thr Val Gly Pro Leu
            3620                3625                3630        
Leu Ala Ala Ala Ala Gly Ala Pro Ala Pro Leu Tyr Leu Gly Gly Leu
        3635                3640                3645            
Pro Glu Pro Met Ala Val Gln Pro Trp Pro Pro Ala Tyr Cys Gly Cys
    3650                3655                3660                
Met Arg Arg Leu Ala Val Asn Arg Ser Pro Val Ala Met Thr Arg Ser
3665                3670                3675                3680
Val Glu Val His Gly Ala Val Gly Ala Ser Gly Cys Pro Ala Ala
                3685                3690                3695


<210> 8967
<211> 115
<212> PRT
<213> Homo sapiens

<400> 8967
Met Gln Ser Arg Gln Arg Ser Cys Phe Pro Thr Pro Gly Phe Asp Ser
 1               5                  10                  15      
Pro Thr Ser Pro Pro Pro Gly Lys Arg Ala Leu Gly Trp His Arg Gly
            20                  25                  30          
Thr Arg Ala Arg Leu Leu Ser Ser Phe Leu Ser Phe Leu Asn Gly Ser
        35                  40                  45              
Ser Ala Asn Gln Ala Val Gly Gln Gly Pro Glu Ala Gly Glu Gly Arg
    50                  55                  60                  
Gly Glu Gly Cys Leu Gln Leu Gly Glu Lys Asn Gly Arg Pro Gln Val
65                  70                  75                  80  
Ser Arg Phe Val Pro Val Trp Gly Phe Ala Asn Gln Thr Gly Ala Glu
                85                  90                  95      
Gly Thr Ala Ala Pro Phe Gln Trp Arg Arg Ser Gln Val Pro His Ala
            100                 105                 110         
Arg Val Tyr
        115 


<210> 8968
<211> 1955
<212> PRT
<213> Homo sapiens

<400> 8968
Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile
 1               5                  10                  15      
Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys
            20                  25                  30          
Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu
        35                  40                  45              
Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly
    50                  55                  60                  
Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn
65                  70                  75                  80  
Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu
                85                  90                  95      
Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His
            100                 105                 110         
Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile
        115                 120                 125             
Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser
    130                 135                 140                 
Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr
145                 150                 155                 160 
Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala
                165                 170                 175     
Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln
            180                 185                 190         
Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu
        195                 200                 205             
Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp
    210                 215                 220                 
Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn
225                 230                 235                 240 
Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu
                245                 250                 255     
Asp Gly Asp Asp Ser Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro
            260                 265                 270         
Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu
        275                 280                 285             
Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile
    290                 295                 300                 
Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro
305                 310                 315                 320 
Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg
                325                 330                 335     
Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro
            340                 345                 350         
Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu
        355                 360                 365             
Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu
    370                 375                 380                 
Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr
385                 390                 395                 400 
Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp
                405                 410                 415     
Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp
            420                 425                 430         
Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr
        435                 440                 445             
Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr
    450                 455                 460                 
Leu Leu Leu Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser
465                 470                 475                 480 
Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn
                485                 490                 495     
Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile
            500                 505                 510         
Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val
        515                 520                 525             
Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile
    530                 535                 540                 
Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys
545                 550                 555                 560 
Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly
                565                 570                 575     
Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala
            580                 585                 590         
Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro
        595                 600                 605             
Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu
    610                 615                 620                 
Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala
625                 630                 635                 640 
Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp
                645                 650                 655     
Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu
            660                 665                 670         
Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile
        675                 680                 685             
Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn
    690                 695                 700                 
Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr
705                 710                 715                 720 
Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val
                725                 730                 735     
Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val
            740                 745                 750         
His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn
        755                 760                 765             
Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr
    770                 775                 780                 
Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His
785                 790                 795                 800 
Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser
                805                 810                 815     
Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu
            820                 825                 830         
Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu
        835                 840                 845             
Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe
    850                 855                 860                 
Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu
865                 870                 875                 880 
Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val
                885                 890                 895     
Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val
            900                 905                 910         
Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys
        915                 920                 925             
Gln Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro
    930                 935                 940                 
Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala
945                 950                 955                 960 
Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala
                965                 970                 975     
Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val
            980                 985                 990         
Asn Leu Asn Glu Glu Pro Thr Thr Ile Phe Lys Leu Val Val Val Ala
        995                 1000                1005            
Phe Asp Asp Gly Glu Pro Val Met Ser Ser Ser Ala Thr Val Lys Ile
    1010                1015                1020                
Leu Val Leu His Pro Gly Glu Ile Pro Arg Phe Thr Gln Glu Glu Tyr
1025                1030                1035                1040
Arg Pro Pro Pro Val Ser Glu Leu Ala Thr Lys Gly Thr Met Val Gly
                1045                1050                1055    
Val Ile Ser Ala Ala Ala Ile Asn Gln Ser Ile Val Tyr Ser Ile Val
            1060                1065                1070        
Ser Gly Asn Glu Glu Asp Thr Phe Gly Ile Asn Asn Ile Thr Gly Val
        1075                1080                1085            
Ile Tyr Val Asn Gly Pro Leu Asp Tyr Glu Thr Arg Thr Ser Tyr Val
    1090                1095                1100                
Leu Arg Val Gln Ala Asp Ser Leu Glu Val Val Leu Ala Asn Leu Arg
1105                1110                1115                1120
Val Pro Ser Lys Ser Asn Thr Ala Lys Val Tyr Ile Glu Ile Gln Asp
                1125                1130                1135    
Glu Asn Asn His Pro Pro Val Phe Gln Lys Lys Phe Tyr Ile Gly Gly
            1140                1145                1150        
Val Ser Glu Asp Ala Arg Met Phe Thr Ser Val Leu Arg Val Lys Ala
        1155                1160                1165            
Thr Asp Lys Asp Thr Gly Asn Tyr Ser Val Met Ala Tyr Arg Leu Ile
    1170                1175                1180                
Ile Pro Pro Ile Lys Glu Gly Lys Glu Gly Phe Val Val Glu Thr Tyr
1185                1190                1195                1200
Thr Gly Leu Ile Lys Thr Ala Met Leu Phe His Asn Met Arg Arg Ser
                1205                1210                1215    
Tyr Phe Lys Phe Gln Val Ile Ala Thr Asp Asp Tyr Gly Lys Gly Leu
            1220                1225                1230        
Ser Gly Lys Ala Asp Val Leu Val Ser Val Val Asn Gln Leu Asp Met
        1235                1240                1245            
Gln Val Ile Val Ser Asn Val Pro Pro Thr Leu Val Glu Lys Lys Ile
    1250                1255                1260                
Glu Asp Leu Thr Glu Ile Leu Asp Arg Tyr Val Arg Glu Gln Ile Pro
1265                1270                1275                1280
Gly Ala Lys Val Val Val Glu Ser Ile Gly Ala Arg Arg His Gly Asp
                1285                1290                1295    
Ala Phe Ser Leu Glu Asp Tyr Thr Lys Cys Asp Leu Thr Val Tyr Ala
            1300                1305                1310        
Ile Asp Pro Gln Thr Asn Arg Ala Ile Asp Arg Asn Glu Leu Phe Lys
        1315                1320                1325            
Phe Leu Asp Gly Lys Leu Leu Asp Ile Asn Lys Asp Phe Gln Pro Tyr
    1330                1335                1340                
Tyr Gly Glu Gly Gly Arg Ile Leu Glu Ile Arg Thr Pro Glu Ala Val
1345                1350                1355                1360
Thr Ser Ile Lys Lys Arg Gly Glu Ser Leu Gly Tyr Thr Glu Gly Ala
                1365                1370                1375    
Leu Leu Ala Leu Ala Phe Ile Ile Ile Leu Cys Cys Ile Pro Ala Ile
            1380                1385                1390        
Leu Val Val Leu Val Ser Tyr Arg Gln Phe Lys Val Arg Gln Ala Glu
        1395                1400                1405            
Cys Thr Lys Thr Ala Arg Ile Gln Ala Ala Leu Pro Ala Ala Lys Pro
    1410                1415                1420                
Ala Val Pro Ala Pro Ala Pro Val Ala Ala Pro Pro Pro Pro Pro Pro
1425                1430                1435                1440
Pro Pro Pro Gly Ala His Leu Tyr Glu Glu Leu Gly Asp Ser Ser Ile
                1445                1450                1455    
Leu Phe Leu Leu Tyr His Phe Gln Gln Ser Arg Gly Asn Asn Ser Val
            1460                1465                1470        
Ser Glu Asp Arg Lys His Gln Gln Val Val Met Pro Phe Ser Ser Asn
        1475                1480                1485            
Thr Ile Glu Ala His Lys Ser Ala His Val Asp Gly Ser Leu Lys Ser
    1490                1495                1500                
Asn Lys Leu Lys Ser Ala Arg Lys Phe Thr Phe Leu Ser Asp Glu Asp
1505                1510                1515                1520
Asp Leu Ser Ala His Asn Pro Leu Tyr Lys Glu Asn Ile Ser Gln Val
                1525                1530                1535    
Ser Thr Asn Ser Asp Ile Ser Gln Arg Thr Asp Phe Val Asp Pro Phe
            1540                1545                1550        
Ser Pro Lys Ile Gln Ala Lys Ser Lys Ser Leu Arg Gly Pro Arg Glu
        1555                1560                1565            
Lys Ile Gln Arg Leu Trp Ser Gln Ser Val Ser Leu Pro Arg Arg Leu
    1570                1575                1580                
Met Arg Lys Val Pro Asn Arg Pro Glu Ile Ile Asp Leu Gln Gln Trp
1585                1590                1595                1600
Gln Gly Thr Arg Gln Lys Ala Glu Asn Glu Asn Thr Gly Ile Cys Thr
                1605                1610                1615    
Asn Lys Arg Gly Ser Ser Asn Pro Leu Leu Thr Thr Glu Glu Ala Asn
            1620                1625                1630        
Leu Thr Glu Lys Glu Glu Ile Arg Gln Gly Glu Thr Leu Met Ile Glu
        1635                1640                1645            
Gly Thr Glu Gln Leu Lys Ser Leu Ser Ser Asp Ser Ser Phe Cys Phe
    1650                1655                1660                
Pro Arg Pro His Phe Ser Phe Ser Thr Leu Pro Thr Val Ser Arg Thr
1665                1670                1675                1680
Val Glu Leu Lys Ser Glu Pro Asn Val Ile Ser Ser Pro Ala Glu Cys
                1685                1690                1695    
Ser Leu Glu Leu Ser Pro Ser Arg Pro Cys Val Leu His Ser Ser Leu
            1700                1705                1710        
Ser Arg Arg Glu Thr Pro Ile Cys Met Leu Pro Ile Glu Thr Glu Arg
        1715                1720                1725            
Asn Ile Phe Glu Asn Phe Ala His Pro Pro Asn Ile Ser Pro Ser Ala
    1730                1735                1740                
Cys Pro Leu Pro Pro Pro Pro Pro Ile Ser Pro Pro Ser Pro Pro Pro
1745                1750                1755                1760
Ala Pro Ala Pro Leu Ala Pro Pro Pro Asp Ile Ser Pro Phe Ser Leu
                1765                1770                1775    
Phe Cys Pro Pro Pro Ser Pro Pro Ser Ile Pro Leu Pro Leu Pro Pro
            1780                1785                1790        
Pro Thr Phe Phe Pro Leu Ser Val Ser Thr Ser Gly Pro Pro Thr Pro
        1795                1800                1805            
Pro Leu Leu Pro Pro Phe Pro Thr Pro Leu Pro Pro Pro Pro Pro Ser
    1810                1815                1820                
Ile Pro Cys Pro Pro Pro Pro Ser Ala Ser Phe Leu Ser Thr Glu Cys
1825                1830                1835                1840
Val Cys Ile Thr Gly Val Lys Cys Thr Thr Asn Leu Met Pro Ala Glu
                1845                1850                1855    
Lys Ile Lys Ser Ser Met Thr Gln Leu Ser Thr Thr Thr Val Cys Lys
            1860                1865                1870        
Thr Asp Pro Gln Arg Glu Pro Lys Gly Ile Leu Arg His Val Lys Asn
        1875                1880                1885            
Leu Ala Glu Leu Glu Lys Ser Val Ala Asn Met Tyr Ser Gln Ile Glu
    1890                1895                1900                
Lys Asn Tyr Leu Arg Thr Asn Val Ser Glu Leu Gln Thr Met Cys Pro
1905                1910                1915                1920
Ser Glu Val Thr Asn Met Glu Ile Thr Ser Glu Gln Asn Lys Gly Ser
                1925                1930                1935    
Leu Asn Asn Ile Val Glu Gly Thr Glu Lys Gln Ser His Ser Gln Ser
            1940                1945                1950        
Thr Ser Leu
        1955


<210> 8969
<211> 1061
<212> PRT
<213> Homo sapiens

<400> 8969
Met Pro Gly Pro Arg Arg Pro Ala Gly Ser Arg Leu Arg Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Leu Arg Gly Ser His Ala
            20                  25                  30          
Gly Asn Leu Thr Val Ala Val Val Leu Pro Leu Ala Asn Thr Ser Tyr
        35                  40                  45              
Pro Trp Ser Trp Ala Arg Val Gly Pro Ala Val Glu Leu Ala Leu Ala
    50                  55                  60                  
Gln Val Lys Ala Arg Pro Asp Leu Leu Pro Gly Trp Thr Val Arg Thr
65                  70                  75                  80  
Val Leu Gly Ser Ser Glu Asn Ala Leu Gly Val Cys Ser Asp Thr Ala
                85                  90                  95      
Ala Pro Leu Ala Ala Val Asp Leu Lys Trp Glu His Asn Pro Ala Val
            100                 105                 110         
Phe Leu Gly Pro Gly Cys Val Tyr Ala Ala Ala Pro Val Gly Arg Phe
        115                 120                 125             
Thr Ala His Trp Arg Val Pro Leu Leu Thr Ala Gly Ala Pro Ala Leu
    130                 135                 140                 
Gly Phe Gly Val Lys Asp Glu Tyr Ala Leu Thr Thr Arg Ala Gly Pro
145                 150                 155                 160 
Ser Tyr Ala Lys Leu Gly Asp Phe Val Ala Ala Leu His Arg Arg Leu
                165                 170                 175     
Gly Trp Glu Arg Gln Ala Leu Met Leu Tyr Ala Tyr Arg Pro Gly Asp
            180                 185                 190         
Glu Glu His Cys Phe Phe Leu Val Glu Gly Leu Phe Met Arg Val Arg
        195                 200                 205             
Asp Arg Leu Asn Ile Thr Val Asp His Leu Glu Phe Ala Glu Asp Asp
    210                 215                 220                 
Leu Ser His Tyr Thr Arg Leu Leu Arg Thr Met Pro Arg Lys Gly Arg
225                 230                 235                 240 
Val Ile Tyr Ile Cys Ser Ser Pro Asp Ala Phe Arg Thr Leu Met Leu
                245                 250                 255     
Leu Ala Leu Glu Ala Gly Leu Cys Gly Glu Asp Tyr Val Phe Phe His
            260                 265                 270         
Leu Asp Ile Phe Gly Gln Ser Leu Gln Gly Gly Gln Gly Pro Ala Pro
        275                 280                 285             
Arg Arg Pro Trp Glu Arg Gly Asp Gly Gln Asp Val Ser Ala Arg Gln
    290                 295                 300                 
Ala Phe Gln Ala Ala Lys Ile Ile Thr Tyr Lys Asp Pro Asp Asn Pro
305                 310                 315                 320 
Glu Tyr Leu Glu Phe Leu Lys Gln Leu Lys His Leu Ala Tyr Glu Gln
                325                 330                 335     
Phe Asn Phe Thr Met Glu Asp Gly Leu Val Asn Thr Ile Pro Ala Ser
            340                 345                 350         
Phe His Asp Gly Leu Leu Leu Tyr Ile Gln Ala Val Thr Glu Thr Leu
        355                 360                 365             
Ala His Gly Gly Thr Val Thr Asp Gly Glu Asn Ile Thr Gln Arg Met
    370                 375                 380                 
Trp Asn Arg Ser Phe Gln Gly Val Thr Gly Tyr Leu Lys Ile Asp Ser
385                 390                 395                 400 
Ser Gly Asp Arg Glu Thr Asp Phe Ser Leu Trp Asp Met Asp Pro Glu
                405                 410                 415     
Asn Gly Ala Phe Arg Val Val Leu Asn Tyr Asn Gly Thr Ser Gln Glu
            420                 425                 430         
Leu Val Ala Val Ser Gly Arg Lys Leu Asn Trp Pro Leu Gly Tyr Pro
        435                 440                 445             
Pro Pro Asp Ile Pro Lys Cys Gly Phe Asp Asn Glu Asp Pro Ala Cys
    450                 455                 460                 
Asn Gln Asp His Leu Ser Thr Leu Glu Val Leu Ala Leu Val Gly Ser
465                 470                 475                 480 
Leu Ser Leu Leu Gly Ile Leu Ile Val Ser Phe Phe Ile Tyr Arg Lys
                485                 490                 495     
Met Gln Leu Glu Lys Glu Leu Ala Ser Glu Leu Trp Arg Val Arg Trp
            500                 505                 510         
Glu Asp Val Glu Pro Ser Ser Leu Glu Arg His Leu Arg Ser Ala Gly
        515                 520                 525             
Ser Arg Leu Thr Leu Ser Gly Arg Gly Ser Asn Tyr Gly Ser Leu Leu
    530                 535                 540                 
Thr Thr Glu Gly Gln Phe Gln Val Phe Ala Lys Thr Ala Tyr Tyr Lys
545                 550                 555                 560 
Gly Asn Leu Val Ala Val Lys Arg Val Asn Arg Lys Arg Ile Glu Leu
                565                 570                 575     
Thr Arg Lys Val Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Asn
            580                 585                 590         
Glu His Leu Thr Arg Phe Val Gly Ala Cys Thr Asp Pro Pro Asn Ile
        595                 600                 605             
Cys Ile Leu Thr Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu
    610                 615                 620                 
Glu Asn Glu Ser Ile Thr Leu Asp Trp Met Phe Arg Tyr Ser Leu Thr
625                 630                 635                 640 
Asn Asp Ile Val Lys Gly Met Leu Phe Leu His Asn Gly Ala Ile Cys
                645                 650                 655     
Ser His Gly Asn Leu Lys Ser Ser Asn Cys Val Val Asp Gly Arg Phe
            660                 665                 670         
Val Leu Lys Ile Thr Asp Tyr Gly Leu Glu Ser Phe Arg Asp Leu Asp
        675                 680                 685             
Pro Glu Gln Gly His Thr Val Tyr Ala Lys Lys Leu Trp Thr Ala Pro
    690                 695                 700                 
Glu Leu Leu Arg Met Ala Ser Pro Pro Val Arg Gly Ser Gln Ala Gly
705                 710                 715                 720 
Asp Val Tyr Ser Phe Gly Ile Ile Leu Gln Glu Ile Ala Leu Arg Ser
                725                 730                 735     
Gly Val Phe His Val Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile Ile
            740                 745                 750         
Glu Arg Val Thr Arg Gly Glu Gln Pro Pro Phe Arg Pro Ser Leu Ala
        755                 760                 765             
Leu Gln Ser His Leu Glu Glu Leu Gly Leu Leu Met Gln Arg Cys Trp
    770                 775                 780                 
Ala Glu Asp Pro Gln Glu Arg Pro Pro Phe Gln Gln Ile Arg Leu Thr
785                 790                 795                 800 
Leu Arg Lys Phe Asn Arg Glu Asn Ser Ser Asn Ile Leu Asp Asn Leu
                805                 810                 815     
Leu Ser Arg Met Glu Gln Tyr Ala Asn Asn Leu Glu Glu Leu Val Glu
            820                 825                 830         
Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala Leu
        835                 840                 845             
Leu Tyr Gln Ile Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg Gly
    850                 855                 860                 
Glu Thr Val Gln Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe Ser
865                 870                 875                 880 
Asp Ile Val Gly Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met Gln
                885                 890                 895     
Val Val Thr Leu Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Val Ile
            900                 905                 910         
Asp Asn Phe Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met
        915                 920                 925             
Val Val Ser Gly Leu Pro Val Arg Asn Gly Arg Leu His Ala Cys Glu
    930                 935                 940                 
Val Ala Arg Met Ala Leu Ala Leu Leu Asp Ala Val Arg Ser Phe Arg
945                 950                 955                 960 
Ile Arg His Arg Pro Gln Glu Gln Leu Arg Leu Arg Ile Gly Ile His
                965                 970                 975     
Thr Gly Pro Val Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg Tyr
            980                 985                 990         
Cys Leu Phe Gly Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Asn
        995                 1000                1005            
Gly Glu Ala Leu Lys Ile His Leu Ser Ser Glu Thr Lys Ala Val Leu
    1010                1015                1020                
Glu Glu Phe Gly Gly Phe Glu Leu Glu Leu Arg Gly Asp Val Glu Met
1025                1030                1035                1040
Lys Gly Lys Gly Lys Val Arg Thr Tyr Trp Leu Leu Gly Glu Arg Gly
                1045                1050                1055    
Ser Ser Thr Arg Gly
            1060    


<210> 8970
<211> 493
<212> PRT
<213> Homo sapiens

<400> 8970
Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu
 1               5                  10                  15      
Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val
            20                  25                  30          
Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro
        35                  40                  45              
Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala
    50                  55                  60                  
Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu
65                  70                  75                  80  
Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu
                85                  90                  95      
Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val
            100                 105                 110         
Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr
        115                 120                 125             
Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile
    130                 135                 140                 
Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu
145                 150                 155                 160 
Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser
                165                 170                 175     
Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp
            180                 185                 190         
Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr
        195                 200                 205             
Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val
    210                 215                 220                 
Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys
225                 230                 235                 240 
Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala
                245                 250                 255     
Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly
            260                 265                 270         
Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile
        275                 280                 285             
Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro
    290                 295                 300                 
Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr
305                 310                 315                 320 
Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser
                325                 330                 335     
Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro
            340                 345                 350         
Arg Phe Pro Gln Ser Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly
        355                 360                 365             
Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg
    370                 375                 380                 
Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr
385                 390                 395                 400 
Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val
                405                 410                 415     
Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Pro
            420                 425                 430         
Glu Gly Gly Ser Pro Pro Pro Thr Cys Thr Gly Asp Leu Arg His Pro
        435                 440                 445             
Ala Gln Leu Arg Pro Pro Ala Pro Asp Pro Thr Gln Arg Leu Pro Gly
    450                 455                 460                 
Glu Ala Glu Glu Pro Met Gln Thr Pro Lys Ala Thr His Leu Gly Ala
465                 470                 475                 480 
Gly Gly Leu Lys His Leu Pro Gly Val Leu Val Pro Phe
                485                 490             


<210> 8971
<211> 651
<212> PRT
<213> Homo sapiens

<400> 8971
Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu
 1               5                  10                  15      
Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val
            20                  25                  30          
Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro
        35                  40                  45              
Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala
    50                  55                  60                  
Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu
65                  70                  75                  80  
Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu
                85                  90                  95      
Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val
            100                 105                 110         
Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr
        115                 120                 125             
Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile
    130                 135                 140                 
Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu
145                 150                 155                 160 
Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser
                165                 170                 175     
Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp
            180                 185                 190         
Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr
        195                 200                 205             
Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val
    210                 215                 220                 
Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys
225                 230                 235                 240 
Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala
                245                 250                 255     
Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly
            260                 265                 270         
Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile
        275                 280                 285             
Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro
    290                 295                 300                 
Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr
305                 310                 315                 320 
Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser
                325                 330                 335     
Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro
            340                 345                 350         
Arg Phe Pro Gln Ser Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly
        355                 360                 365             
Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg
    370                 375                 380                 
Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr
385                 390                 395                 400 
Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val
                405                 410                 415     
Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val
            420                 425                 430         
Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu
        435                 440                 445             
Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Gly Gly Gly Pro Ser
    450                 455                 460                 
Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly Gly Val
465                 470                 475                 480 
Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val Leu Val
                485                 490                 495     
His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Ser Gly Lys Ala Pro
            500                 505                 510         
Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro Asp His
        515                 520                 525             
Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro Lys Pro
    530                 535                 540                 
Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro Ala Ser
545                 550                 555                 560 
Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly Gly Ser
                565                 570                 575     
Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro Glu Gly
            580                 585                 590         
Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu Ala Asp
        595                 600                 605             
Val Val Val Leu Ser Ala Pro Thr Leu Asp Val Asp Gly Ala Ser Asp
    610                 615                 620                 
Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly Gly Pro
625                 630                 635                 640 
Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile
                645                 650     


<210> 8972
<211> 845
<212> PRT
<213> Homo sapiens

<400> 8972
Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu
 1               5                  10                  15      
Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val
            20                  25                  30          
Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro
        35                  40                  45              
Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala
    50                  55                  60                  
Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu
65                  70                  75                  80  
Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu
                85                  90                  95      
Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val
            100                 105                 110         
Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr
        115                 120                 125             
Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile
    130                 135                 140                 
Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu
145                 150                 155                 160 
Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser
                165                 170                 175     
Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp
            180                 185                 190         
Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr
        195                 200                 205             
Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val
    210                 215                 220                 
Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys
225                 230                 235                 240 
Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala
                245                 250                 255     
Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly
            260                 265                 270         
Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile
        275                 280                 285             
Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro
    290                 295                 300                 
Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr
305                 310                 315                 320 
Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser
                325                 330                 335     
Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro
            340                 345                 350         
Arg Phe Pro Gln Ser Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly
        355                 360                 365             
Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg
    370                 375                 380                 
Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr
385                 390                 395                 400 
Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val
                405                 410                 415     
Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val
            420                 425                 430         
Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu
        435                 440                 445             
Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Asp Val Pro Pro Ser
    450                 455                 460                 
Pro Glu Ala Gly Gly Thr Thr Gly Pro Trp Thr Ser Thr Thr Ser Glu
465                 470                 475                 480 
Val Pro Arg Pro Pro Glu Pro Ser Gln Gly Pro Ser Thr Thr Ser Ser
                485                 490                 495     
Gly Gly Gly Thr Gly Pro His Pro Pro Ser Gly Thr Thr Leu Arg Pro
            500                 505                 510         
Pro Thr Ser Ser Thr Pro Gly Gly Ser Pro Gly Ala Glu Asn Ser Thr
        515                 520                 525             
Ser His Gln Pro Ala Thr Pro Gly Gly Asp Thr Ala Gln Thr Pro Lys
    530                 535                 540                 
Pro Gly Thr Ser Gln Pro Met Pro Pro Gly Val Gly Thr Ser Thr Ser
545                 550                 555                 560 
His Gln Pro Ala Thr Pro Ser Gly Gly Thr Val Gln Thr Pro Glu Pro
                565                 570                 575     
Gly Thr Ser Gln Pro Met Pro Pro Ser Met Gly Thr Ser Thr Ser His
            580                 585                 590         
Gln Pro Ala Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Ala Gly
        595                 600                 605             
Thr Ser Gln Pro Met Pro Pro Gly Met Gly Thr Ser Thr Ser His Gln
    610                 615                 620                 
Pro Thr Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr
625                 630                 635                 640 
Ser Gln Pro Met Pro Leu Ser Lys Ser Thr Pro Ser Ser Gly Gly Gly
                645                 650                 655     
Pro Ser Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly
            660                 665                 670         
Gly Val Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val
        675                 680                 685             
Leu Val His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Ser Gly Lys
    690                 695                 700                 
Ala Pro Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro
705                 710                 715                 720 
Asp His Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro
                725                 730                 735     
Lys Pro Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro
            740                 745                 750         
Ala Ser Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly
        755                 760                 765             
Gly Ser Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro
    770                 775                 780                 
Glu Gly Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu
785                 790                 795                 800 
Ala Asp Val Val Val Leu Asn Ala Pro Thr Leu Asp Val Asp Gly Ala
                805                 810                 815     
Ser Asp Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly
            820                 825                 830         
Gly Pro Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile
        835                 840                 845 


<210> 8973
<211> 845
<212> PRT
<213> Homo sapiens

<400> 8973
Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu
 1               5                  10                  15      
Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val
            20                  25                  30          
Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro
        35                  40                  45              
Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala
    50                  55                  60                  
Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu
65                  70                  75                  80  
Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu
                85                  90                  95      
Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val
            100                 105                 110         
Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr
        115                 120                 125             
Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile
    130                 135                 140                 
Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu
145                 150                 155                 160 
Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser
                165                 170                 175     
Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp
            180                 185                 190         
Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr
        195                 200                 205             
Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val
    210                 215                 220                 
Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys
225                 230                 235                 240 
Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala
                245                 250                 255     
Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly
            260                 265                 270         
Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile
        275                 280                 285             
Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro
    290                 295                 300                 
Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr
305                 310                 315                 320 
Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser
                325                 330                 335     
Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro
            340                 345                 350         
Arg Phe Pro Gln Ser Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly
        355                 360                 365             
Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg
    370                 375                 380                 
Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr
385                 390                 395                 400 
Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val
                405                 410                 415     
Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val
            420                 425                 430         
Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu
        435                 440                 445             
Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Asp Val Pro Pro Ser
    450                 455                 460                 
Pro Glu Ala Gly Gly Thr Thr Gly Pro Trp Thr Gly Thr Thr Ser Glu
465                 470                 475                 480 
Val Pro Arg Pro Pro Glu Pro Ser Gln Gly Pro Ser Thr Thr Ser Ser
                485                 490                 495     
Gly Glu Gly Thr Gly Pro His Pro Pro Ser Gly Thr Thr Leu Arg Pro
            500                 505                 510         
Pro Thr Ser Ser Thr Pro Gly Gly Ser Pro Gly Ala Glu Asn Ser Thr
        515                 520                 525             
Ser His Gln Pro Ala Thr Pro Gly Gly Asp Thr Ala Gln Thr Pro Lys
    530                 535                 540                 
Pro Gly Thr Ser Gln Pro Met Pro Pro Gly Val Gly Thr Ser Thr Ser
545                 550                 555                 560 
His Gln Pro Ala Thr Pro Ser Gly Gly Thr Val Gln Thr Pro Glu Pro
                565                 570                 575     
Gly Thr Ser Gln Pro Met Pro Pro Ser Met Gly Thr Ser Thr Ser His
            580                 585                 590         
Gln Pro Ala Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Ala Gly
        595                 600                 605             
Thr Ser Gln Pro Met Pro Pro Gly Met Gly Thr Ser Thr Ser His Gln
    610                 615                 620                 
Pro Thr Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr
625                 630                 635                 640 
Ser Gln Pro Met Pro Leu Ser Lys Ser Thr Pro Ser Ser Gly Gly Gly
                645                 650                 655     
Pro Ser Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly
            660                 665                 670         
Gly Val Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val
        675                 680                 685             
Leu Val His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Ser Gly Lys
    690                 695                 700                 
Ala Pro Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro
705                 710                 715                 720 
Asp His Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro
                725                 730                 735     
Lys Pro Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro
            740                 745                 750         
Ala Ser Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly
        755                 760                 765             
Gly Ser Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro
    770                 775                 780                 
Glu Gly Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu
785                 790                 795                 800 
Ala Asp Val Val Val Leu Ser Ala Pro Thr Leu Asp Val Asp Gly Ala
                805                 810                 815     
Ser Asp Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly
            820                 825                 830         
Gly Pro Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile
        835                 840                 845 


<210> 8974
<211> 3623
<212> PRT
<213> Homo sapiens

<400> 8974
Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu
 1               5                  10                  15      
Ile Phe Ala Glu Val Asn Gly Glu Arg Gly Glu Leu Glu Leu Gln Arg
            20                  25                  30          
Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg
        35                  40                  45              
Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg
    50                  55                  60                  
Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu
65                  70                  75                  80  
Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys
                85                  90                  95      
Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln
            100                 105                 110         
Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln
        115                 120                 125             
Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly
    130                 135                 140                 
Gly Asn Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro
145                 150                 155                 160 
Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile
                165                 170                 175     
Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn
            180                 185                 190         
Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro
        195                 200                 205             
Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg
    210                 215                 220                 
Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu
225                 230                 235                 240 
Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Ser Ser Pro Asn
                245                 250                 255     
Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly
            260                 265                 270         
Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr
        275                 280                 285             
Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu
    290                 295                 300                 
Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro
305                 310                 315                 320 
Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys
                325                 330                 335     
Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile
            340                 345                 350         
Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser
        355                 360                 365             
Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly
    370                 375                 380                 
Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu
385                 390                 395                 400 
Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr
                405                 410                 415     
Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn
            420                 425                 430         
Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val
        435                 440                 445             
Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly
    450                 455                 460                 
Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly
465                 470                 475                 480 
Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His
                485                 490                 495     
Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu
            500                 505                 510         
Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro
        515                 520                 525             
His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln
    530                 535                 540                 
Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser
545                 550                 555                 560 
Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly
                565                 570                 575     
Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly
            580                 585                 590         
Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly
        595                 600                 605             
Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro
    610                 615                 620                 
Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His
625                 630                 635                 640 
Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr
                645                 650                 655     
Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro
            660                 665                 670         
Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser
        675                 680                 685             
Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser
    690                 695                 700                 
Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe
705                 710                 715                 720 
Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr
                725                 730                 735     
Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His
            740                 745                 750         
Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val
        755                 760                 765             
Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile
    770                 775                 780                 
Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile
785                 790                 795                 800 
Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala
                805                 810                 815     
Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe
            820                 825                 830         
Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln
        835                 840                 845             
Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly
    850                 855                 860                 
Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser
865                 870                 875                 880 
Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro
                885                 890                 895     
Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys
            900                 905                 910         
Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu
        915                 920                 925             
Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln
    930                 935                 940                 
Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp
945                 950                 955                 960 
His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr
                965                 970                 975     
Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val
            980                 985                 990         
Tyr Asp Thr Asp Ser Glu Thr Ser Leu Gly Arg Tyr Cys Gly Lys Ser
        995                 1000                1005            
Ile Pro Pro Ser Leu Thr Ser Ser Gly Asn Ser Leu Met Leu Val Phe
    1010                1015                1020                
Val Thr Asp Ser Asp Leu Ala Tyr Glu Gly Phe Leu Ile Asn Tyr Glu
1025                1030                1035                1040
Ala Ile Ser Ala Ala Thr Ala Cys Leu Gln Asp Tyr Thr Asp Asp Leu
                1045                1050                1055    
Gly Thr Phe Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp
            1060                1065                1070        
Glu Cys Ile Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val
        1075                1080                1085            
His Phe Thr Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr
    1090                1095                1100                
Asp Phe Leu Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu
1105                1110                1115                1120
Gly Ile Phe Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser
                1125                1130                1135    
Asn Lys Leu Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser
            1140                1145                1150        
Gly Phe Ser Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn
        1155                1160                1165            
Leu Thr Thr Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro
    1170                1175                1180                
Tyr Tyr His Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly
1185                1190                1195                1200
Ser Ala Phe Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro
                1205                1210                1215    
Asn Cys Thr Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn
            1220                1225                1230        
Ser His Leu Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile
        1235                1240                1245            
Arg Ser Ser Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly
    1250                1255                1260                
Gln Gln Gly Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn
1265                1270                1275                1280
Val Val Ile Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr
                1285                1290                1295    
Pro Asn Pro Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala
            1300                1305                1310        
Thr Thr Gly Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu
        1315                1320                1325            
His His Ile Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro
    1330                1335                1340                
Arg Gln Met Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser
1345                1350                1355                1360
Thr Thr Ser Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly
                1365                1370                1375    
Arg Arg Glu Lys Gly Phe Gln Met Gln Trp Phe Val Tyr Gly Cys Gly
            1380                1385                1390        
Gly Glu Leu Ser Gly Ala Thr Gly Ser Phe Ser Ser Pro Gly Phe Pro
        1395                1400                1405            
Asn Arg Tyr Pro Pro Asn Lys Glu Cys Ile Trp Tyr Ile Arg Thr Asp
    1410                1415                1420                
Pro Gly Ser Ser Ile Gln Leu Thr Ile His Asp Phe Asp Val Glu Tyr
1425                1430                1435                1440
His Ser Arg Cys Asn Phe Asp Val Leu Glu Ile Tyr Gly Gly Pro Asp
                1445                1450                1455    
Phe His Ser Pro Arg Ile Ala Gln Leu Cys Thr Gln Arg Ser Pro Glu
            1460                1465                1470        
Asn Pro Met Gln Val Ser Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe
        1475                1480                1485            
Lys Thr Asp Leu Ser Ile Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln
    1490                1495                1500                
Ala Val Thr Gly Gly Cys Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu
1505                1510                1515                1520
Ile His Ser Pro Asn Tyr Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys
                1525                1530                1535    
Ser Trp Val Ile Arg Val Asp Arg Tyr His Arg Val Leu Leu Asn Phe
            1540                1545                1550        
Thr Asp Phe Asp Leu Glu Pro Gln Asp Ser Cys Ile Met Ala Tyr Asp
        1555                1560                1565            
Gly Leu Ser Ser Thr Met Ser Arg Leu Ala Arg Thr Cys Gly Arg Glu
    1570                1575                1580                
Gln Leu Ala Asn Pro Ile Val Ser Ser Gly Asn Ser Leu Phe Leu Arg
1585                1590                1595                1600
Phe Gln Ser Gly Pro Ser Arg Gln Asn Arg Gly Phe Arg Ala Gln Phe
                1605                1610                1615    
Arg Gln Ala Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val
            1620                1625                1630        
Ser Ser Pro Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser
        1635                1640                1645            
Trp Ile Ile Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe
    1650                1655                1660                
Thr His Phe Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val
1665                1670                1675                1680
Glu Ile Leu Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr
                1685                1690                1695    
Cys Gly Thr Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu
            1700                1705                1710        
Thr Leu Arg Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His
        1715                1720                1725            
Thr Thr Val Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met
    1730                1735                1740                
Ala Glu Gly Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro
1745                1750                1755                1760
Asn Val Glu Cys Val Trp Asn Ile Ile Ser Ser Pro Gly Asn Arg Leu
                1765                1770                1775    
Gln Leu Ser Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser
            1780                1785                1790        
Arg Asp Phe Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val
        1795                1800                1805            
Gly Arg Tyr Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val
    1810                1815                1820                
Gly His Thr Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly
1825                1830                1835                1840
Thr Gly Phe Gln Ala Thr Phe Met Lys Ile Phe Gly Asn Asp Asn Ile
                1845                1850                1855    
Val Gly Thr His Gly Lys Val Ala Ser Pro Phe Trp Pro Glu Asn Tyr
            1860                1865                1870        
Pro His Asn Ser Asn Tyr Gln Trp Thr Val Asn Val Asn Ala Ser His
        1875                1880                1885            
Val Val His Gly Arg Ile Leu Glu Met Asp Ile Glu Glu Ile Gln Asn
    1890                1895                1900                
Cys Tyr Tyr Asp Lys Leu Arg Ile Tyr Asp Gly Pro Ser Ile His Ala
1905                1910                1915                1920
Arg Leu Ile Gly Ala Tyr Cys Gly Thr Gln Thr Glu Ser Phe Ser Ser
                1925                1930                1935    
Thr Gly Asn Ser Leu Thr Phe His Phe Tyr Ser Asp Ser Ser Ile Ser
            1940                1945                1950        
Gly Lys Gly Phe Leu Leu Glu Trp Phe Ala Val Asp Ala Pro Asp Gly
        1955                1960                1965            
Val Leu Pro Thr Ile Ala Pro Gly Ala Cys Gly Gly Phe Leu Arg Thr
    1970                1975                1980                
Gly Asp Ala Pro Val Phe Leu Phe Ser Pro Gly Trp Pro Asp Ser Tyr
1985                1990                1995                2000
Ser Asn Arg Val Asp Cys Thr Trp Leu Ile Gln Ala Pro Asp Ser Thr
                2005                2010                2015    
Val Glu Leu Asn Ile Leu Ser Leu Asp Ile Glu Ser His Arg Thr Cys
            2020                2025                2030        
Ala Tyr Asp Ser Leu Val Ile Arg Asp Gly Asp Asn Asn Leu Ala Gln
        2035                2040                2045            
Gln Leu Ala Val Leu Cys Gly Arg Glu Ile Pro Gly Pro Ile Arg Ser
    2050                2055                2060                
Thr Gly Glu Tyr Met Phe Ile Arg Phe Thr Ser Asp Ser Ser Val Thr
2065                2070                2075                2080
Arg Ala Gly Phe Asn Ala Ser Phe His Lys Ser Cys Gly Gly Tyr Leu
                2085                2090                2095    
His Ala Asp Arg Gly Ile Ile Thr Ser Pro Lys Tyr Pro Glu Thr Tyr
            2100                2105                2110        
Pro Ser Asn Leu Asn Cys Ser Trp His Val Leu Val Gln Ser Gly Leu
        2115                2120                2125            
Thr Ile Ala Val His Phe Glu Gln Pro Phe Gln Ile Pro Asn Gly Asp
    2130                2135                2140                
Ser Ser Cys Asn Gln Gly Asp Tyr Leu Val Leu Arg Asn Gly Pro Asp
2145                2150                2155                2160
Ile Tyr Ser Pro Pro Leu Gly Pro Pro Gly Gly Asn Gly His Phe Cys
                2165                2170                2175    
Gly Ser His Ala Ser Ser Thr Leu Phe Thr Ser Asp Asn Gln Met Phe
            2180                2185                2190        
Val Gln Phe Ile Ser Asp His Ser Asn Glu Gly Gln Gly Phe Lys Ile
        2195                2200                2205            
Lys Tyr Glu Ala Lys Ser Leu Ala Cys Gly Gly Asn Val Tyr Ile His
    2210                2215                2220                
Asp Ala Asp Ser Ala Gly Tyr Val Thr Ser Pro Asn His Pro His Asn
2225                2230                2235                2240
Tyr Pro Pro His Ala Asp Cys Ile Trp Ile Leu Ala Ala Pro Pro Glu
                2245                2250                2255    
Thr Arg Ile Gln Leu Gln Phe Glu Asp Arg Phe Asp Ile Glu Val Thr
            2260                2265                2270        
Pro Asn Cys Thr Ser Asn Tyr Leu Glu Leu Arg Asp Gly Val Asp Ser
        2275                2280                2285            
Asp Ala Pro Ile Leu Ser Lys Phe Cys Gly Thr Ser Leu Pro Ser Ser
    2290                2295                2300                
Gln Trp Ser Ser Gly Glu Val Met Tyr Leu Arg Phe Arg Ser Asp Asn
2305                2310                2315                2320
Ser Pro Thr His Val Gly Phe Lys Ala Lys Tyr Ser Ile Ala Gln Cys
                2325                2330                2335    
Gly Gly Arg Val Pro Gly Gln Ser Gly Val Val Glu Ser Ile Gly His
            2340                2345                2350        
Pro Thr Leu Pro Tyr Arg Asp Asn Leu Phe Cys Glu Trp His Leu Gln
        2355                2360                2365            
Gly Leu Ser Gly His Tyr Leu Thr Ile Ser Phe Glu Asp Phe Asn Leu
    2370                2375                2380                
Gln Asn Ser Ser Gly Cys Glu Lys Asp Phe Val Glu Ile Trp Asp Asn
2385                2390                2395                2400
His Thr Ser Gly Asn Ile Leu Gly Arg Tyr Cys Gly Asn Thr Ile Pro
                2405                2410                2415    
Asp Ser Ile Asp Thr Ser Ser Asn Thr Ala Val Val Arg Phe Val Thr
            2420                2425                2430        
Asp Gly Ser Val Thr Ala Ser Gly Phe Arg Leu Arg Phe Glu Ser Ser
        2435                2440                2445            
Met Glu Glu Cys Gly Gly Asp Leu Gln Gly Ser Ile Gly Thr Phe Thr
    2450                2455                2460                
Ser Pro Asn Tyr Pro Asn Pro Asn Pro His Gly Arg Ile Cys Glu Trp
2465                2470                2475                2480
Arg Ile Thr Ala Pro Glu Gly Arg Arg Ile Thr Leu Met Phe Asn Asn
                2485                2490                2495    
Leu Arg Leu Ala Thr His Pro Ser Cys Asn Asn Glu His Val Ile Val
            2500                2505                2510        
Phe Asn Gly Ile Arg Ser Asn Ser Pro Gln Leu Glu Lys Leu Cys Ser
        2515                2520                2525            
Ser Val Asn Val Ser Asn Glu Ile Lys Ser Ser Gly Asn Thr Met Lys
    2530                2535                2540                
Val Ile Phe Phe Thr Asp Gly Ser Arg Pro Tyr Gly Gly Phe Thr Ala
2545                2550                2555                2560
Ser Tyr Thr Ser Ser Glu Asp Ala Val Cys Gly Gly Ser Leu Pro Asn
                2565                2570                2575    
Thr Pro Glu Gly Asn Phe Thr Ser Pro Gly Tyr Asp Gly Val Arg Asn
            2580                2585                2590        
Tyr Ser Arg Asn Leu Asn Cys Glu Trp Thr Leu Ser Asn Pro Asn Gln
        2595                2600                2605            
Gly Asn Ser Ser Ile Ser Ile His Phe Glu Asp Phe Tyr Leu Glu Ser
    2610                2615                2620                
His Gln Asp Cys Gln Phe Asp Val Leu Glu Phe Arg Val Gly Asp Ala
2625                2630                2635                2640
Asp Gly Pro Leu Met Trp Arg Leu Cys Gly Pro Ser Lys Pro Thr Leu
                2645                2650                2655    
Pro Leu Val Ile Pro Tyr Ser Gln Val Trp Ile His Phe Val Thr Asn
            2660                2665                2670        
Glu Arg Val Glu His Ile Gly Phe His Ala Lys Tyr Ser Phe Thr Asp
        2675                2680                2685            
Cys Gly Gly Ile Gln Ile Gly Asp Ser Gly Val Ile Thr Ser Pro Asn
    2690                2695                2700                
Tyr Pro Asn Ala Tyr Asp Ser Leu Thr His Cys Ser Trp Leu Leu Glu
2705                2710                2715                2720
Ala Pro Gln Gly His Thr Ile Thr Leu Thr Phe Ser Asp Phe Asp Ile
                2725                2730                2735    
Glu Pro His Thr Thr Cys Ala Trp Asp Ser Val Thr Val Arg Asn Gly
            2740                2745                2750        
Gly Ser Pro Glu Ser Pro Ile Ile Gly Gln Tyr Cys Gly Asn Ser Asn
        2755                2760                2765            
Pro Arg Thr Ile Gln Ser Gly Ser Asn Gln Leu Val Val Thr Phe Asn
    2770                2775                2780                
Ser Asp His Ser Leu Gln Gly Gly Gly Phe Tyr Ala Thr Trp Asn Thr
2785                2790                2795                2800
Gln Thr Leu Gly Cys Gly Gly Ile Phe His Ser Asp Asn Gly Thr Ile
                2805                2810                2815    
Arg Ser Pro His Trp Pro Gln Asn Phe Pro Glu Asn Ser Arg Cys Ser
            2820                2825                2830        
Trp Thr Ala Ile Thr His Lys Ser Lys His Leu Glu Ile Ser Phe Asp
        2835                2840                2845            
Asn Asn Phe Leu Ile Pro Ser Gly Asp Gly Gln Cys Gln Asn Ser Phe
    2850                2855                2860                
Val Lys Val Trp Ala Gly Thr Glu Glu Val Asp Lys Ala Leu Leu Ala
2865                2870                2875                2880
Thr Gly Cys Gly Asn Val Ala Pro Gly Pro Val Ile Thr Pro Ser Asn
                2885                2890                2895    
Thr Phe Thr Ala Val Phe Gln Ser Gln Glu Ala Pro Ala Gln Gly Phe
            2900                2905                2910        
Ser Ala Ser Phe Val Ser Arg Cys Gly Ser Asn Phe Thr Gly Pro Ser
        2915                2920                2925            
Gly Tyr Ile Ile Ser Pro Asn Tyr Pro Lys Gln Tyr Asp Asn Asn Met
    2930                2935                2940                
Asn Cys Thr Tyr Val Ile Glu Ala Asn Pro Leu Ser Val Val Leu Leu
2945                2950                2955                2960
Thr Phe Val Ser Phe His Leu Glu Ala Arg Ser Ala Val Thr Gly Ser
                2965                2970                2975    
Cys Val Asn Asp Gly Val His Ile Ile Arg Gly Tyr Ser Val Met Ser
            2980                2985                2990        
Thr Pro Phe Ala Thr Val Cys Gly Asp Glu Met Pro Ala Pro Leu Thr
        2995                3000                3005            
Ile Ala Gly Pro Val Leu Leu Asn Phe Tyr Ser Asn Glu Gln Ile Thr
    3010                3015                3020                
Asp Phe Gly Phe Lys Phe Ser Tyr Arg Ile Ile Ser Cys Gly Gly Val
3025                3030                3035                3040
Phe Asn Phe Ser Ser Gly Ile Ile Thr Ser Pro Ala Tyr Ser Tyr Ala
                3045                3050                3055    
Asp Tyr Pro Asn Asp Met His Cys Leu Tyr Thr Ile Thr Val Ser Asp
            3060                3065                3070        
Asp Lys Val Ile Glu Leu Lys Phe Ser Asp Phe Asp Val Val Pro Ser
        3075                3080                3085            
Thr Ser Cys Ser His Asp Tyr Leu Ala Ile Tyr Asp Gly Ala Asn Thr
    3090                3095                3100                
Ser Asp Pro Leu Leu Gly Lys Phe Cys Gly Ser Lys Arg Pro Pro Asn
3105                3110                3115                3120
Val Lys Ser Ser Asn Asn Ser Met Leu Leu Val Phe Lys Thr Asp Ser
                3125                3130                3135    
Phe Gln Thr Ala Lys Gly Trp Lys Met Ser Phe Arg Gln Thr Leu Gly
            3140                3145                3150        
Pro Gln Gln Gly Cys Gly Gly Tyr Leu Thr Gly Ser Asn Asn Thr Phe
        3155                3160                3165            
Ala Ser Pro Asp Ser Asp Ser Asn Gly Met Tyr Asp Lys Asn Leu Asn
    3170                3175                3180                
Cys Val Trp Ile Ile Ile Ala Pro Val Asn Lys Val Ile His Leu Thr
3185                3190                3195                3200
Phe Asn Thr Phe Ala Leu Glu Ala Ala Ser Thr Arg Gln Arg Cys Leu
                3205                3210                3215    
Tyr Asp Tyr Val Lys Leu Tyr Asp Gly Asp Ser Glu Asn Ala Asn Leu
            3220                3225                3230        
Ala Gly Thr Phe Cys Gly Ser Thr Val Pro Ala Pro Phe Ile Ser Ser
        3235                3240                3245            
Gly Asn Phe Leu Thr Val Gln Phe Ile Ser Asp Leu Thr Leu Glu Arg
    3250                3255                3260                
Glu Gly Phe Asn Ala Thr Tyr Thr Ile Met Asp Met Pro Cys Gly Gly
3265                3270                3275                3280
Thr Tyr Asn Ala Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro Asn Ser
                3285                3290                3295    
Ser Asp Pro Asp Val Pro Phe Ser Ile Cys Thr Trp Val Ile Asp Ser
            3300                3305                3310        
Pro Pro His Gln Gln Val Lys Ile Thr Val Trp Ala Leu Gln Leu Thr
        3315                3320                3325            
Ser Gln Asp Cys Thr Gln Asn Tyr Leu Gln Leu Gln Asp Ser Pro Gln
    3330                3335                3340                
Gly His Gly Asn Ser Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala
3345                3350                3355                3360
Val Pro Val Phe Tyr Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys
                3365                3370                3375    
Ser Gly Val Val Asn Arg Asn Ser Arg Met Ser Phe Thr Tyr Gln Ile
            3380                3385                3390        
Ala Asp Cys Asn Arg Asp Tyr His Lys Ala Phe Gly Asn Leu Arg Ser
        3395                3400                3405            
Pro Gly Trp Pro Asp Asn Tyr Asp Asn Asp Lys Asp Cys Thr Val Thr
    3410                3415                3420                
Leu Thr Ala Pro Gln Asn His Thr Ile Ser Leu Phe Phe His Ser Leu
3425                3430                3435                3440
Gly Ile Glu Asn Ser Val Glu Cys Arg Asn Asp Phe Leu Glu Val Arg
                3445                3450                3455    
Asn Gly Ser Asn Ser Asn Ser Pro Leu Leu Gly Lys Tyr Cys Gly Thr
            3460                3465                3470        
Leu Leu Pro Asn Pro Val Phe Ser Gln Asn Asn Glu Leu Tyr Leu Arg
        3475                3480                3485            
Phe Lys Ser Asp Ser Val Thr Ser Asp Arg Gly Tyr Glu Ile Ile Trp
    3490                3495                3500                
Thr Ser Ser Pro Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg Gly
3505                3510                3515                3520
Ser Phe Thr Ser Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr Tyr
                3525                3530                3535    
Cys Glu Trp Val Leu Val Ala Pro Ala Gly Arg Leu Val Thr Ile Asn
            3540                3545                3550        
Phe Tyr Phe Ile Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn Tyr
        3555                3560                3565            
Leu Thr Leu Tyr Asp Gly Pro Asn Ala Ser Ser Pro Ser Ser Gly Pro
    3570                3575                3580                
Tyr Cys Gly Gly Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser Asn
3585                3590                3595                3600
Gln Val Phe Ile Lys Phe His Ala Asp Tyr Ala Arg Arg Pro Ser Ala
                3605                3610                3615    
Phe Arg Leu Thr Trp Asp Ser
            3620            


<210> 8975
<211> 443
<212> PRT
<213> Homo sapiens

<400> 8975
Met Lys Leu Arg Ser Lys Ala Ala Ala Leu Leu Leu Leu Ala Leu Ala
 1               5                  10                  15      
Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Ala Gly Arg Ala Glu Pro
            20                  25                  30          
Pro Ala Leu Pro Ala Arg Pro Ala Ser Ala Pro Gln Arg His Pro Ala
        35                  40                  45              
Pro Val Pro Ala Arg Trp Pro Gly Pro Gly Ala Leu Pro Gly Ala Ser
    50                  55                  60                  
Pro Gly Val Arg Arg Arg Arg Pro Pro Arg Pro Arg Pro Arg Ala Gly
65                  70                  75                  80  
Arg Arg Gly Ala Ala Arg Leu Glu Lys Leu Ala Arg Arg Pro Gly Glu
                85                  90                  95      
Pro Arg Ser Phe Gln Ala Val Leu Pro Pro Glu Leu Trp Ile His Leu
            100                 105                 110         
Ala Val Val Ala Cys Gly Asn Arg Leu Glu Glu Thr Leu Val Met Leu
        115                 120                 125             
Lys Ser Ala Val Leu Phe Ser His Arg Lys Ile Gln Phe His Ile Phe
    130                 135                 140                 
Thr Glu Asp Ser Leu Lys Pro Glu Phe Asp Lys Gln Leu Arg Gln Trp
145                 150                 155                 160 
Pro Asp Ser Tyr Thr Lys Lys Phe Glu His Arg Ile Tyr Pro Ile Thr
                165                 170                 175     
Phe Ser Val Gly Asn Pro Gln Glu Trp Lys Lys Leu Phe Lys Pro Cys
            180                 185                 190         
Ala Ala Gln Arg Leu Phe Leu Pro Val Ile Leu Lys Asp Val Asp Ser
        195                 200                 205             
Leu Leu Tyr Val Asp Thr Asp Val Leu Phe Leu Arg Pro Val Asp Asp
    210                 215                 220                 
Ile Trp Lys Leu Leu Arg Leu Phe Asn Ser Thr Gln Leu Ala Ala Met
225                 230                 235                 240 
Ala Pro Glu His Glu Ile Pro Lys Ile Gly Trp Tyr Ser Arg Phe Ala
                245                 250                 255     
Arg His Pro Phe Tyr Gly Ser Ala Gly Val Asn Ser Gly Val Met Leu
            260                 265                 270         
Met Asn Leu Thr Arg Ile Arg Ser Thr Gln Phe Lys Asn Ser Met Ile
        275                 280                 285             
Pro Thr Gly Leu Ala Trp Glu Asp Met Leu Tyr Pro Leu Tyr Gln Lys
    290                 295                 300                 
Tyr Lys Asn Ala Ile Thr Trp Gly Asp Gln Asp Leu Leu Asn Ile Ile
305                 310                 315                 320 
Phe Tyr Phe Asn Pro Glu Cys Leu Tyr Val Phe Pro Cys Gln Trp Asn
                325                 330                 335     
Tyr Arg Pro Asp His Cys Met Tyr Gly Ser Asn Cys Arg Glu Ala Glu
            340                 345                 350         
His Glu Gly Val Ser Val Leu His Gly Asn Arg Gly Val Tyr His Asp
        355                 360                 365             
Asp Lys Gln Pro Thr Phe Arg Ala Leu Tyr Glu Ala Ile Arg Asp Phe
    370                 375                 380                 
Pro Phe Gln Asp Asn Leu Phe Gln Ser Met Tyr Tyr Pro Leu Gln Leu
385                 390                 395                 400 
Lys Phe Leu Glu Thr Val His Thr Leu Cys Gly Arg Ile Pro Gln Val
                405                 410                 415     
Phe Leu Lys Gln Ile Glu Lys Thr Met Lys Arg Ala Tyr Glu Lys His
            420                 425                 430         
Val Ile Ile His Val Gly Pro Asn Gln Met His
        435                 440             


<210> 8976
<211> 863
<212> PRT
<213> Homo sapiens

<400> 8976
Met Val Pro Glu Ala Trp Arg Ser Gly Leu Val Ser Thr Gly Arg Val
 1               5                  10                  15      
Val Gly Val Leu Leu Leu Leu Gly Ala Leu Asn Lys Ala Ser Thr Val
            20                  25                  30          
Ile His Tyr Glu Ile Pro Glu Glu Arg Glu Lys Gly Phe Ala Val Gly
        35                  40                  45              
Asn Val Val Ala Asn Leu Gly Leu Asp Leu Gly Ser Leu Ser Ala Arg
    50                  55                  60                  
Arg Phe Arg Val Val Ser Gly Ala Ser Arg Arg Phe Phe Glu Val Asn
65                  70                  75                  80  
Arg Glu Thr Gly Glu Met Phe Val Asn Asp Arg Leu Asp Arg Glu Glu
                85                  90                  95      
Leu Cys Gly Thr Leu Pro Ser Cys Thr Val Thr Leu Glu Leu Val Val
            100                 105                 110         
Glu Asn Pro Leu Glu Leu Phe Ser Val Glu Val Val Ile Gln Asp Ile
        115                 120                 125             
Asn Asp Asn Asn Pro Ala Phe Pro Thr Gln Glu Met Lys Leu Glu Ile
    130                 135                 140                 
Ser Glu Ala Val Ala Pro Gly Thr Arg Phe Pro Leu Glu Ser Ala His
145                 150                 155                 160 
Asp Pro Asp Val Gly Ser Asn Ser Leu Gln Thr Tyr Glu Leu Ser Arg
                165                 170                 175     
Asn Glu Tyr Phe Ala Leu Arg Val Gln Thr Arg Glu Asp Ser Thr Lys
            180                 185                 190         
Tyr Ala Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Arg Glu Pro
        195                 200                 205             
Ser Leu Gln Leu Val Leu Thr Ala Leu Asp Gly Gly Thr Pro Ala Leu
    210                 215                 220                 
Ser Ala Ser Leu Pro Ile His Ile Lys Val Leu Asp Ala Asn Asp Asn
225                 230                 235                 240 
Ala Pro Val Phe Asn Gln Ser Leu Tyr Arg Ala Arg Val Leu Glu Asp
                245                 250                 255     
Ala Pro Ser Gly Thr Arg Val Val Gln Val Leu Ala Thr Asp Leu Asp
            260                 265                 270         
Glu Gly Pro Asn Gly Glu Ile Ile Tyr Ser Phe Gly Ser His Asn Arg
        275                 280                 285             
Ala Gly Val Arg Gln Leu Phe Ala Leu Asp Leu Val Thr Gly Met Leu
    290                 295                 300                 
Thr Ile Lys Gly Arg Leu Asp Phe Glu Asp Thr Lys Leu His Glu Ile
305                 310                 315                 320 
Tyr Ile Gln Ala Lys Asp Lys Gly Ala Asn Pro Glu Gly Ala His Cys
                325                 330                 335     
Lys Val Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile
            340                 345                 350         
Thr Val Thr Ser Val Tyr Ser Pro Val Pro Glu Asp Ala Pro Leu Gly
        355                 360                 365             
Thr Val Ile Ala Leu Leu Ser Val Thr Asp Leu Asp Ala Gly Glu Asn
    370                 375                 380                 
Gly Leu Val Thr Cys Glu Val Pro Pro Gly Leu Pro Phe Ser Leu Thr
385                 390                 395                 400 
Ser Ser Leu Lys Asn Tyr Phe Thr Leu Lys Thr Ser Ala Asp Leu Asp
                405                 410                 415     
Arg Glu Thr Val Pro Glu Tyr Asn Leu Ser Ile Thr Ala Arg Asp Ala
            420                 425                 430         
Gly Thr Pro Ser Leu Ser Ala Leu Thr Ile Val Arg Val Gln Val Ser
        435                 440                 445             
Asp Ile Asn Asp Asn Pro Pro Gln Ser Ser Gln Ser Ser Tyr Asp Val
    450                 455                 460                 
Tyr Ile Glu Glu Asn Asn Leu Pro Gly Ala Pro Ile Leu Asn Leu Ser
465                 470                 475                 480 
Val Trp Asp Pro Asp Ala Pro Gln Asn Ala Arg Leu Ser Phe Phe Leu
                485                 490                 495     
Leu Glu Gln Gly Ala Glu Thr Gly Leu Val Gly Arg Tyr Phe Thr Ile
            500                 505                 510         
Asn Arg Asp Asn Gly Ile Val Ser Ser Leu Val Pro Leu Asp Tyr Glu
        515                 520                 525             
Asp Arg Arg Glu Phe Glu Leu Thr Ala His Ile Ser Asp Gly Gly Thr
    530                 535                 540                 
Pro Val Leu Ala Thr Asn Ile Ser Val Asn Ile Phe Val Thr Asp Arg
545                 550                 555                 560 
Asn Asp Asn Ala Pro Gln Val Leu Tyr Pro Arg Pro Gly Gly Ser Ser
                565                 570                 575     
Val Glu Met Leu Pro Arg Gly Thr Ser Ala Gly His Leu Val Ser Arg
            580                 585                 590         
Val Val Gly Trp Asp Ala Asp Ala Gly His Asn Ala Trp Leu Ser Tyr
        595                 600                 605             
Ser Leu Leu Gly Ser Pro Asn Gln Ser Leu Phe Ala Ile Gly Leu His
    610                 615                 620                 
Thr Gly Gln Ile Ser Thr Ala Arg Pro Val Gln Asp Thr Asp Ser Pro
625                 630                 635                 640 
Arg Gln Thr Leu Thr Val Leu Ile Lys Asp Asn Gly Glu Pro Ser Leu
                645                 650                 655     
Ser Thr Thr Ala Thr Leu Thr Val Ser Val Thr Glu Asp Ser Pro Glu
            660                 665                 670         
Ala Arg Ala Glu Phe Pro Ser Gly Ser Ala Pro Arg Glu Gln Lys Lys
        675                 680                 685             
Asn Leu Thr Phe Tyr Leu Leu Leu Ser Leu Ile Leu Val Ser Val Gly
    690                 695                 700                 
Phe Val Val Thr Val Phe Gly Val Ile Ile Phe Lys Val Tyr Lys Trp
705                 710                 715                 720 
Lys Gln Ser Arg Asp Leu Tyr Arg Ala Pro Val Ser Ser Leu Tyr Arg
                725                 730                 735     
Thr Pro Gly Pro Ser Leu His Ala Asp Ala Val Arg Gly Gly Leu Met
            740                 745                 750         
Ser Pro His Leu Tyr His Gln Val Tyr Leu Thr Thr Asp Ser Arg Arg
        755                 760                 765             
Ser Asp Pro Leu Leu Lys Lys Pro Gly Ala Ala Ser Pro Leu Ala Ser
    770                 775                 780                 
Arg Gln Asn Thr Leu Arg Ser Cys Asp Pro Val Phe Tyr Arg Gln Val
785                 790                 795                 800 
Leu Gly Ala Glu Ser Ala Pro Pro Gly Gln Val Arg Phe Ser Lys Ser
                805                 810                 815     
Cys Leu Thr Leu Leu Val Leu Phe Tyr Ser Tyr Ile Ile Leu Arg Lys
            820                 825                 830         
Glu Trp Ser Cys Phe Phe Ser Asp Glu Asp Val Phe Leu Val Met His
        835                 840                 845             
Ser His Phe Gln Leu Ala Leu Pro Arg Ser Lys Leu Val Pro Leu
    850                 855                 860             


<210> 8977
<211> 352
<212> PRT
<213> Homo sapiens

<400> 8977
Met Thr Ser Ser Leu Leu Leu Ala Phe Leu Leu Leu Ala Pro Thr Thr
 1               5                  10                  15      
Val Ala Thr Pro Arg Ala Gly Gly Gln Cys Pro Ala Cys Gly Gly Pro
            20                  25                  30          
Thr Leu Glu Leu Glu Ser Gln Arg Glu Leu Leu Leu Asp Leu Ala Lys
        35                  40                  45              
Arg Ser Ile Leu Asp Lys Leu His Leu Thr Gln Arg Pro Thr Leu Asn
    50                  55                  60                  
Arg Pro Val Ser Arg Ala Ala Leu Arg Thr Ala Leu Gln His Leu His
65                  70                  75                  80  
Gly Val Pro Gln Gly Ala Leu Leu Glu Asp Asn Arg Glu Gln Glu Cys
                85                  90                  95      
Glu Ile Ile Ser Phe Ala Glu Thr Gly Leu Ser Thr Ile Asn Gln Thr
            100                 105                 110         
Arg Leu Asp Phe His Phe Ser Ser Asp Arg Thr Ala Gly Asp Arg Glu
        115                 120                 125             
Val Gln Gln Ala Ser Leu Met Phe Phe Val Gln Leu Pro Ser Asn Thr
    130                 135                 140                 
Thr Trp Thr Leu Lys Val Arg Val Leu Val Leu Gly Pro His Asn Thr
145                 150                 155                 160 
Asn Leu Thr Leu Ala Thr Gln Tyr Leu Leu Glu Val Asp Ala Ser Gly
                165                 170                 175     
Trp His Gln Leu Pro Leu Gly Pro Glu Ala Gln Ala Ala Cys Ser Gln
            180                 185                 190         
Gly His Leu Thr Leu Glu Leu Val Leu Glu Gly Gln Val Ala Gln Ser
        195                 200                 205             
Ser Val Ile Leu Gly Gly Ala Ala His Arg Pro Phe Val Ala Ala Arg
    210                 215                 220                 
Val Arg Val Gly Gly Lys His Gln Ile His Arg Arg Gly Ile Asp Cys
225                 230                 235                 240 
Gln Gly Gly Ser Arg Met Cys Cys Arg Gln Glu Phe Phe Val Asp Phe
                245                 250                 255     
Arg Glu Ile Gly Trp His Asp Trp Ile Ile Gln Pro Glu Gly Tyr Ala
            260                 265                 270         
Met Asn Phe Cys Ile Gly Gln Cys Pro Leu His Ile Ala Gly Met Pro
        275                 280                 285             
Gly Ile Ala Ala Ser Phe His Thr Ala Val Leu Asn Leu Leu Lys Ala
    290                 295                 300                 
Asn Thr Ala Ala Gly Thr Thr Gly Gly Gly Ser Cys Cys Val Pro Thr
305                 310                 315                 320 
Ala Arg Arg Pro Leu Ser Leu Leu Tyr Tyr Asp Arg Asp Ser Asn Ile
                325                 330                 335     
Val Lys Thr Asp Ile Pro Asp Met Val Val Glu Ala Cys Gly Cys Ser
            340                 345                 350         


<210> 8978
<211> 655
<212> PRT
<213> Homo sapiens

<400> 8978
Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg
 1               5                  10                  15      
Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu
            20                  25                  30          
Leu Gly Phe Leu Ser Thr Thr Thr Ala Gln Pro Glu Gln Lys Ala Ser
        35                  40                  45              
Asn Leu Ile Gly Thr Tyr Arg His Val Asp Arg Ala Thr Gly Gln Val
    50                  55                  60                  
Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys
65                  70                  75                  80  
Thr Asn Thr Ser Leu Arg Val Cys Ser Ser Cys Pro Val Gly Thr Phe
                85                  90                  95      
Thr Arg His Glu Asn Gly Ile Glu Lys Cys His Asp Cys Ser Gln Pro
            100                 105                 110         
Cys Pro Trp Pro Met Ile Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp
        115                 120                 125             
Arg Glu Cys Thr Cys Pro Pro Gly Met Phe Gln Ser Asn Ala Thr Cys
    130                 135                 140                 
Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly
145                 150                 155                 160 
Thr Glu Thr Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe
                165                 170                 175     
Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala Tyr Thr Asp Cys
            180                 185                 190         
Leu Ser Gln Asn Leu Val Val Ile Lys Pro Gly Thr Lys Glu Thr Asp
        195                 200                 205             
Asn Val Cys Gly Thr Leu Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser
    210                 215                 220                 
Pro Gly Thr Ala Ile Phe Pro Arg Pro Glu His Met Glu Thr His Glu
225                 230                 235                 240 
Val Pro Ser Ser Thr Tyr Val Pro Lys Gly Met Asn Ser Thr Glu Ser
                245                 250                 255     
Asn Ser Ser Ala Ser Val Arg Pro Lys Val Leu Ser Ser Ile Gln Glu
            260                 265                 270         
Gly Thr Val Pro Asp Asn Thr Ser Ser Ala Arg Gly Lys Glu Asp Val
        275                 280                 285             
Asn Lys Thr Leu Pro Asn Leu Gln Val Val Asn His Gln Gln Gly Pro
    290                 295                 300                 
His His Arg His Ile Leu Lys Leu Leu Pro Ser Met Glu Ala Thr Gly
305                 310                 315                 320 
Gly Glu Lys Ser Ser Thr Pro Ile Lys Gly Pro Lys Arg Gly His Pro
                325                 330                 335     
Arg Gln Asn Leu His Lys His Phe Asp Ile Asn Glu His Leu Pro Trp
            340                 345                 350         
Met Ile Val Leu Phe Leu Leu Leu Val Leu Val Val Ile Val Val Cys
        355                 360                 365             
Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp
    370                 375                 380                 
Pro Ser Ala Ile Val Glu Lys Ala Gly Leu Lys Lys Ser Met Thr Pro
385                 390                 395                 400 
Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr Cys Asn Gly His Gly Ile
                405                 410                 415     
Asp Ile Leu Lys Leu Val Ala Ala Gln Val Gly Ser Gln Trp Lys Asp
            420                 425                 430         
Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu Arg Glu Val Ala Ala Phe
        435                 440                 445             
Ser Asn Gly Tyr Thr Ala Asp His Glu Arg Ala Tyr Ala Ala Leu Gln
    450                 455                 460                 
His Trp Thr Ile Arg Gly Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser
465                 470                 475                 480 
Ala Leu Arg Gln His Arg Arg Asn Asp Val Val Glu Lys Ile Arg Gly
                485                 490                 495     
Leu Met Glu Asp Thr Thr Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro
            500                 505                 510         
Met Ser Pro Ser Pro Leu Ser Pro Ser Pro Ile Pro Ser Pro Asn Ala
        515                 520                 525             
Lys Leu Glu Asn Ser Ala Leu Leu Thr Val Glu Pro Ser Pro Gln Asp
    530                 535                 540                 
Lys Asn Lys Gly Phe Phe Val Asp Glu Ser Glu Pro Leu Leu Arg Cys
545                 550                 555                 560 
Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe
                565                 570                 575     
Ile Thr Lys Glu Lys Lys Asp Thr Val Leu Arg Gln Val Arg Leu Asp
            580                 585                 590         
Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp Met Leu His Phe Leu Asn
        595                 600                 605             
Pro Glu Glu Leu Arg Val Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys
    610                 615                 620                 
Leu Asp Arg Leu Phe Glu Ile Ile Gly Val Lys Ser Gln Glu Ala Ser
625                 630                 635                 640 
Gln Thr Leu Leu Asp Ser Val Tyr Ser His Leu Pro Asp Leu Leu
                645                 650                 655 


<210> 8979
<211> 820
<212> PRT
<213> Homo sapiens

<400> 8979
Met Gly Gly Ser Cys Ala Gln Arg Arg Arg Ala Gly Pro Arg Gln Val
 1               5                  10                  15      
Leu Phe Pro Leu Leu Leu Pro Leu Phe Tyr Pro Thr Leu Ser Glu Pro
            20                  25                  30          
Ile Arg Tyr Ser Ile Pro Glu Glu Leu Ala Lys Gly Ser Val Val Gly
        35                  40                  45              
Asn Leu Ala Lys Asp Leu Gly Leu Ser Val Leu Asp Val Ser Ala Arg
    50                  55                  60                  
Lys Leu Arg Val Ser Ala Glu Lys Leu His Phe Ser Val Asp Ala Glu
65                  70                  75                  80  
Ser Gly Asp Leu Leu Val Lys Asn Arg Ile Asp Arg Glu Gln Ile Cys
                85                  90                  95      
Lys Glu Arg Arg Arg Cys Glu Leu Gln Leu Glu Ala Val Val Glu Asn
            100                 105                 110         
Pro Leu Asn Ile Phe His Val Ile Val Val Ile Glu Asp Val Asn Asp
        115                 120                 125             
His Ala Pro Gln Phe Asp Lys Lys Glu Ile His Leu Glu Ile Phe Glu
    130                 135                 140                 
Ser Ala Ser Ala Gly Thr Arg Leu Ser Leu Asp Pro Ala Thr Asp Pro
145                 150                 155                 160 
Asp Ile Asn Ile Asn Ser Ile Lys Asp Tyr Lys Ile Asn Ser Asn Pro
                165                 170                 175     
Tyr Phe Ser Leu Met Val Arg Val Asn Ser Asp Gly Gly Lys Tyr Pro
            180                 185                 190         
Glu Leu Ser Leu Glu Lys Leu Leu Asp Arg Glu Glu Gln Arg Ser His
        195                 200                 205             
Ser Leu Ile Leu Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Ser Ala
    210                 215                 220                 
Thr Ala His Ile Glu Ile Ser Val Lys Asp Thr Asn Asp Asn Pro Pro
225                 230                 235                 240 
Val Phe Ser Arg Asp Glu Tyr Arg Ile Ser Leu Ser Glu Asn Leu Pro
                245                 250                 255     
Pro Gly Ser Pro Val Leu Gln Val Thr Ala Thr Asp Gln Asp Glu Gly
            260                 265                 270         
Val Asn Ala Glu Ile Asn Tyr Tyr Phe Arg Ser Thr Ala Gln Ser Thr
        275                 280                 285             
Lys His Met Phe Ser Leu Asp Glu Lys Thr Gly Met Ile Lys Asn Asn
    290                 295                 300                 
Gln Ser Phe Asp Phe Glu Asp Val Glu Arg Tyr Thr Met Glu Val Glu
305                 310                 315                 320 
Ala Lys Asp Gly Gly Gly Leu Ser Thr Gln Cys Lys Val Ile Ile Glu
                325                 330                 335     
Ile Leu Asp Glu Asn Asp Asn Ser Pro Glu Ile Ile Ile Thr Ser Leu
            340                 345                 350         
Ser Asp Gln Ile Leu Glu Asn Ser Pro Pro Gly Met Val Val Ala Leu
        355                 360                 365             
Phe Lys Thr Arg Asp Leu Asp Phe Gly Gly Asn Gly Glu Val Arg Cys
    370                 375                 380                 
Asn Ile Glu Thr Asp Ile Pro Phe Lys Ile Tyr Ser Ser Ser Asn Asn
385                 390                 395                 400 
Tyr Tyr Lys Leu Val Thr Asp Gly Ala Leu Asp Arg Glu Gln Thr Pro
                405                 410                 415     
Glu Tyr Asn Val Thr Ile Val Ala Thr Asp Arg Gly Lys Pro Pro Leu
            420                 425                 430         
Ser Ser Ser Arg Ser Ile Thr Leu Tyr Val Ala Asp Ile Asn Asp Asn
        435                 440                 445             
Ala Pro Val Phe Asp Gln Thr Ser Tyr Val Val His Val Ala Glu Asn
    450                 455                 460                 
Asn Pro Pro Gly Ala Ser Ile Ala Gln Val Ser Ala Ser Asp Pro Asp
465                 470                 475                 480 
Leu Gly Leu Asn Gly His Ile Ser Tyr Ser Ile Val Ala Ser Asp Leu
                485                 490                 495     
Glu Pro Leu Ala Val Ser Ser Tyr Val Ser Val Ser Ala Gln Ser Gly
            500                 505                 510         
Val Val Phe Ala Gln Arg Ala Phe Asp His Glu Gln Leu Arg Ala Phe
        515                 520                 525             
Ala Leu Thr Leu Gln Ala Arg Asp His Gly Ser Pro Thr Leu Ser Ala
    530                 535                 540                 
Asn Val Ser Leu Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro
545                 550                 555                 560 
Arg Val Leu Tyr Pro Ala Leu Gly Pro Asp Gly Ser Ala Phe Phe Asp
                565                 570                 575     
Met Val Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Ala Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val
        595                 600                 605             
Leu Gln Ala Ser Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln
625                 630                 635                 640 
Arg Leu Leu Val Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Ala Thr Leu His Leu Val Phe Ala Asp Asn Leu Gln Glu Ile Leu
            660                 665                 670         
Pro Asp Leu Ser Asp Arg Pro Val Leu Ser Asp Pro Gln Ala Glu Leu
        675                 680                 685             
Gln Phe Tyr Leu Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu
    690                 695                 700                 
Leu Ala Val Ile Leu Ala Ile Ala Leu Arg Leu Arg Arg Ser Leu Ser
705                 710                 715                 720 
Pro Ala Thr Trp Asp Cys Phe His Pro Gly Leu Cys Val Lys Ser Gly
                725                 730                 735     
Pro Val Val Pro Pro Asn Tyr Ser Glu Gly Thr Leu Pro Tyr Ser Tyr
            740                 745                 750         
Asn Leu Cys Ile Ala His Thr Gly Thr Lys Glu Phe Asn Phe Leu Lys
        755                 760                 765             
Cys Ser Val Pro Leu His Ser Asn Glu Asp Met Val Cys Ser Val Ser
    770                 775                 780                 
Pro Gly Ala Leu Ile Pro Pro His Gly Gly Glu Asp Leu Thr Ser His
785                 790                 795                 800 
Pro Glu Thr Leu Thr Ser Val Ser Phe Ser Phe Leu Cys Val Ile Tyr
                805                 810                 815     
Leu Ile Val Tyr
            820 


<210> 8980
<211> 1612
<212> PRT
<213> Homo sapiens

<400> 8980
Met Ile Ala Glu Pro Ala His Phe Tyr Leu Phe Gly Leu Ile Cys Leu
 1               5                  10                  15      
Cys Ser Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg Ile Val
            20                  25                  30          
Glu His Pro Ser Asp Leu Ile Val Ser Lys Gly Glu Pro Ala Thr Leu
        35                  40                  45              
Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp Tyr Lys
    50                  55                  60                  
Gly Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser His Arg
65                  70                  75                  80  
Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val His Gly
                85                  90                  95      
Arg Lys Ser Arg Pro Asp Glu Gly Val Tyr Val Cys Val Ala Arg Asn
            100                 105                 110         
Tyr Leu Gly Glu Ala Val Ser His Asn Ala Ser Leu Glu Val Ala Ile
        115                 120                 125             
Leu Arg Asp Asp Phe Arg Gln Asn Pro Ser Asp Val Met Val Ala Val
    130                 135                 140                 
Gly Glu Pro Ala Val Met Glu Cys Gln Pro Pro Arg Gly His Pro Glu
145                 150                 155                 160 
Pro Thr Ile Ser Trp Lys Lys Asp Gly Ser Pro Leu Asp Asp Lys Asp
                165                 170                 175     
Glu Arg Ile Thr Ile Arg Gly Gly Lys Leu Met Ile Thr Tyr Thr Arg
            180                 185                 190         
Lys Ser Asp Ala Gly Lys Tyr Val Cys Val Gly Thr Asn Met Val Gly
        195                 200                 205             
Glu Arg Glu Ser Glu Val Ala Glu Leu Thr Val Leu Glu Arg Pro Ser
    210                 215                 220                 
Phe Val Lys Arg Pro Ser Asn Leu Ala Val Thr Val Asp Asp Ser Ala
225                 230                 235                 240 
Glu Phe Lys Cys Glu Ala Arg Gly Asp Pro Val Pro Thr Val Arg Trp
                245                 250                 255     
Arg Lys Asp Asp Gly Glu Leu Pro Lys Ser Arg Tyr Glu Ile Arg Asp
            260                 265                 270         
Asp His Thr Leu Lys Ile Arg Lys Val Thr Ala Gly Asp Met Gly Ser
        275                 280                 285             
Tyr Thr Cys Val Ala Glu Asn Met Val Gly Lys Ala Glu Ala Ser Ala
    290                 295                 300                 
Thr Leu Thr Val Gln Glu Pro Pro His Phe Val Val Lys Pro Arg Asp
305                 310                 315                 320 
Gln Val Val Ala Leu Gly Arg Thr Val Thr Phe Gln Cys Glu Ala Thr
                325                 330                 335     
Gly Asn Pro Gln Pro Ala Ile Phe Trp Arg Arg Glu Gly Ser Gln Asn
            340                 345                 350         
Leu Leu Phe Ser Tyr Gln Pro Pro Gln Ser Ser Ser Arg Phe Ser Val
        355                 360                 365             
Ser Gln Thr Gly Asp Leu Thr Ile Thr Asn Val Gln Arg Ser Asp Val
    370                 375                 380                 
Gly Tyr Tyr Ile Cys Gln Thr Leu Asn Val Ala Gly Ser Ile Ile Thr
385                 390                 395                 400 
Lys Ala Tyr Leu Glu Val Thr Asp Val Ile Ala Asp Arg Pro Pro Pro
                405                 410                 415     
Val Ile Arg Gln Gly Pro Val Asn Gln Thr Val Ala Val Asp Gly Thr
            420                 425                 430         
Phe Val Leu Ser Cys Val Ala Thr Gly Ser Pro Val Pro Thr Ile Leu
        435                 440                 445             
Trp Arg Lys Asp Gly Val Leu Val Ser Thr Gln Asp Ser Arg Ile Lys
    450                 455                 460                 
Gln Leu Glu Asn Gly Val Leu Gln Ile Arg Tyr Ala Lys Leu Gly Asp
465                 470                 475                 480 
Thr Gly Arg Tyr Thr Cys Ile Ala Ser Thr Pro Ser Gly Glu Ala Thr
                485                 490                 495     
Trp Ser Ala Tyr Ile Glu Val Gln Glu Phe Gly Val Pro Val Gln Pro
            500                 505                 510         
Pro Arg Pro Thr Asp Pro Asn Leu Ile Pro Ser Ala Pro Ser Lys Pro
        515                 520                 525             
Glu Val Thr Asp Val Ser Arg Asn Thr Val Thr Leu Ser Trp Gln Pro
    530                 535                 540                 
Asn Leu Asn Ser Gly Ala Thr Pro Thr Ser Tyr Ile Ile Glu Ala Phe
545                 550                 555                 560 
Ser His Ala Ser Gly Ser Ser Trp Gln Thr Val Ala Glu Asn Val Lys
                565                 570                 575     
Thr Glu Thr Ser Ala Ile Lys Gly Leu Lys Pro Asn Ala Ile Tyr Leu
            580                 585                 590         
Phe Leu Val Arg Ala Ala Asn Ala Tyr Gly Ile Ser Asp Pro Ser Gln
        595                 600                 605             
Ile Ser Asp Pro Val Lys Thr Gln Asp Val Leu Pro Thr Ser Gln Gly
    610                 615                 620                 
Val Asp His Lys Gln Val Gln Arg Glu Leu Gly Asn Ala Val Leu His
625                 630                 635                 640 
Leu His Asn Pro Thr Val Leu Ser Ser Ser Ser Ile Glu Val His Trp
                645                 650                 655     
Thr Val Asp Gln Gln Ser Gln Tyr Ile Gln Gly Tyr Lys Ile Leu Tyr
            660                 665                 670         
Arg Pro Ser Gly Ala Asn His Gly Glu Ser Asp Trp Leu Val Phe Glu
        675                 680                 685             
Val Arg Thr Pro Ala Lys Asn Ser Val Val Ile Pro Asp Leu Arg Lys
    690                 695                 700                 
Gly Val Asn Tyr Glu Ile Lys Ala Arg Pro Phe Phe Asn Glu Phe Gln
705                 710                 715                 720 
Gly Ala Asp Ser Glu Ile Lys Phe Ala Lys Thr Leu Glu Glu Ala Pro
                725                 730                 735     
Ser Ala Pro Pro Gln Gly Val Thr Val Ser Lys Asn Asp Gly Asn Gly
            740                 745                 750         
Thr Ala Ile Leu Val Ser Trp Gln Pro Pro Pro Glu Asp Thr Gln Asn
        755                 760                 765             
Gly Met Val Gln Glu Tyr Lys Val Trp Cys Leu Gly Asn Glu Thr Arg
    770                 775                 780                 
Tyr His Ile Asn Lys Thr Val Asp Gly Ser Thr Phe Ser Val Val Ile
785                 790                 795                 800 
Pro Phe Leu Val Pro Gly Ile Arg Tyr Ser Val Glu Val Ala Ala Ser
                805                 810                 815     
Thr Gly Ala Gly Ser Gly Val Lys Ser Glu Pro Gln Phe Ile Gln Leu
            820                 825                 830         
Asp Ala His Gly Asn Pro Val Ser Pro Glu Asp Gln Val Ser Leu Ala
        835                 840                 845             
Gln Gln Ile Ser Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly Ile
    850                 855                 860                 
Gly Ala Ala Cys Trp Ile Ile Leu Met Val Phe Ser Ile Trp Leu Tyr
865                 870                 875                 880 
Arg His Arg Lys Lys Arg Asn Gly Leu Thr Ser Thr Tyr Ala Gly Ile
                885                 890                 895     
Arg Lys Val Pro Ser Phe Thr Phe Thr Pro Thr Val Thr Tyr Gln Arg
            900                 905                 910         
Gly Gly Glu Ala Val Ser Ser Gly Gly Arg Pro Gly Leu Leu Asn Ile
        915                 920                 925             
Ser Glu Pro Ala Ala Gln Pro Trp Leu Ala Asp Thr Trp Pro Asn Thr
    930                 935                 940                 
Gly Asn Asn His Asn Asp Cys Ser Ile Ser Cys Cys Thr Ala Gly Asn
945                 950                 955                 960 
Gly Asn Ser Asp Ser Asn Leu Thr Thr Tyr Ser Arg Pro Ala Asp Cys
                965                 970                 975     
Ile Ala Asn Tyr Asn Asn Gln Leu Asp Asn Lys Gln Thr Asn Leu Met
            980                 985                 990         
Leu Pro Glu Ser Thr Val Tyr Gly Asp Val Asp Leu Ser Asn Lys Ile
        995                 1000                1005            
Asn Glu Met Lys Thr Phe Asn Ser Pro Asn Leu Lys Asp Gly Arg Phe
    1010                1015                1020                
Val Asn Pro Ser Gly Gln Pro Thr Pro Tyr Ala Thr Thr Gln Leu Ile
1025                1030                1035                1040
Gln Ser Asn Leu Ser Asn Asn Met Asn Asn Gly Ser Gly Asp Ser Gly
                1045                1050                1055    
Glu Lys His Trp Lys Pro Leu Gly Gln Gln Lys Gln Glu Val Ala Pro
            1060                1065                1070        
Val Gln Tyr Asn Ile Val Glu Gln Asn Lys Leu Asn Lys Asp Tyr Arg
        1075                1080                1085            
Ala Asn Asp Thr Val Pro Pro Thr Ile Pro Tyr Asn Gln Ser Tyr Asp
    1090                1095                1100                
Gln Asn Thr Gly Gly Ser Tyr Asn Ser Ser Asp Arg Gly Ser Ser Thr
1105                1110                1115                1120
Ser Gly Ser Gln Gly His Lys Lys Gly Ala Arg Thr Pro Lys Val Pro
                1125                1130                1135    
Lys Gln Gly Gly Met Asn Trp Ala Asp Leu Leu Pro Pro Pro Pro Ala
            1140                1145                1150        
His Pro Pro Pro His Ser Asn Ser Glu Glu Tyr Asn Ile Ser Val Asp
        1155                1160                1165            
Glu Ser Tyr Asp Gln Glu Met Pro Cys Pro Val Pro Pro Ala Arg Met
    1170                1175                1180                
Tyr Leu Gln Gln Asp Glu Leu Glu Glu Glu Glu Asp Glu Arg Gly Pro
1185                1190                1195                1200
Thr Pro Pro Val Arg Gly Ala Ala Ser Ser Pro Ala Ala Val Ser Tyr
                1205                1210                1215    
Ser His Gln Ser Thr Ala Thr Leu Thr Pro Ser Pro Gln Glu Glu Leu
            1220                1225                1230        
Gln Pro Met Leu Gln Asp Cys Pro Glu Glu Thr Gly His Met Gln His
        1235                1240                1245            
Gln Pro Asp Arg Arg Arg Gln Pro Val Ser Pro Pro Pro Pro Pro Arg
    1250                1255                1260                
Pro Ile Ser Pro Pro His Thr Tyr Gly Tyr Ile Ser Gly Pro Leu Val
1265                1270                1275                1280
Ser Asp Met Asp Thr Asp Ala Pro Glu Glu Glu Glu Asp Glu Ala Asp
                1285                1290                1295    
Met Glu Val Ala Lys Met Gln Thr Arg Arg Leu Leu Leu Arg Gly Leu
            1300                1305                1310        
Glu Gln Thr Pro Ala Ser Ser Val Gly Asp Leu Glu Ser Ser Val Thr
        1315                1320                1325            
Gly Ser Met Ile Asn Gly Trp Gly Ser Ala Ser Glu Glu Asp Asn Ile
    1330                1335                1340                
Ser Ser Gly Arg Ser Ser Val Ser Ser Ser Asp Gly Ser Phe Phe Thr
1345                1350                1355                1360
Asp Ala Asp Phe Ala Gln Ala Val Ala Ala Ala Ala Glu Tyr Ala Gly
                1365                1370                1375    
Leu Lys Val Ala Arg Arg Gln Met Gln Asp Ala Ala Gly Arg Arg His
            1380                1385                1390        
Phe His Ala Ser Gln Cys Pro Arg Pro Thr Ser Pro Val Ser Thr Asp
        1395                1400                1405            
Ser Asn Met Ser Ala Ala Val Met Gln Lys Thr Arg Pro Ala Lys Lys
    1410                1415                1420                
Leu Lys His Gln Pro Gly His Leu Arg Arg Glu Thr Tyr Thr Asp Asp
1425                1430                1435                1440
Leu Pro Pro Pro Pro Val Pro Pro Pro Ala Ile Lys Ser Pro Thr Ala
                1445                1450                1455    
Gln Ser Lys Thr Gln Leu Glu Val Arg Pro Val Val Val Pro Lys Leu
            1460                1465                1470        
Pro Ser Met Asp Ala Arg Thr Asp Arg Ser Ser Asp Arg Lys Gly Ser
        1475                1480                1485            
Ser Tyr Lys Gly Arg Glu Val Leu Asp Gly Arg Gln Val Val Asp Met
    1490                1495                1500                
Arg Thr Asn Pro Gly Asp Pro Arg Glu Ala Gln Glu Gln Gln Asn Asp
1505                1510                1515                1520
Gly Lys Gly Arg Gly Asn Lys Ala Ala Lys Arg Asp Leu Pro Pro Ala
                1525                1530                1535    
Lys Thr His Leu Ile Gln Glu Asp Ile Leu Pro Tyr Cys Arg Pro Thr
            1540                1545                1550        
Phe Pro Thr Ser Asn Asn Pro Arg Asp Pro Ser Ser Ser Ser Ser Met
        1555                1560                1565            
Ser Ser Arg Gly Ser Gly Ser Arg Gln Arg Glu Gln Ala Asn Val Gly
    1570                1575                1580                
Arg Arg Asn Ile Ala Glu Met Gln Val Leu Gly Gly Tyr Glu Arg Gly
1585                1590                1595                1600
Glu Asp Asn Asn Glu Glu Leu Glu Glu Thr Glu Ser
                1605                1610        


<210> 8981
<211> 1651
<212> PRT
<213> Homo sapiens

<400> 8981
Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser
 1               5                  10                  15      
Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu
            20                  25                  30          
Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp
        35                  40                  45              
Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu
    50                  55                  60                  
Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser
65                  70                  75                  80  
Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr
                85                  90                  95      
Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys
            100                 105                 110         
Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe
        115                 120                 125             
Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val
    130                 135                 140                 
Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn
145                 150                 155                 160 
Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro
                165                 170                 175     
Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln
            180                 185                 190         
Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly
        195                 200                 205             
Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys
    210                 215                 220                 
Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys
225                 230                 235                 240 
Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu
                245                 250                 255     
Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala
            260                 265                 270         
Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp
        275                 280                 285             
Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys
    290                 295                 300                 
Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val
305                 310                 315                 320 
Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val
                325                 330                 335     
Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His
            340                 345                 350         
Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val
        355                 360                 365             
Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp
    370                 375                 380                 
Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln
385                 390                 395                 400 
Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr
                405                 410                 415     
Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn
            420                 425                 430         
Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val
        435                 440                 445             
Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln
    450                 455                 460                 
Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly
465                 470                 475                 480 
Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser
                485                 490                 495     
Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile
            500                 505                 510         
Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser
        515                 520                 525             
Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu
    530                 535                 540                 
Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile
545                 550                 555                 560 
Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr
                565                 570                 575     
Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr
            580                 585                 590         
Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln
        595                 600                 605             
Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu
    610                 615                 620                 
Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr
625                 630                 635                 640 
Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp
                645                 650                 655     
Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu
            660                 665                 670         
Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser
        675                 680                 685             
Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile
    690                 695                 700                 
Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu
705                 710                 715                 720 
Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val
                725                 730                 735     
Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg
            740                 745                 750         
Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala
        755                 760                 765             
Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val
    770                 775                 780                 
Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro
785                 790                 795                 800 
Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp
                805                 810                 815     
Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly
            820                 825                 830         
Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr
        835                 840                 845             
Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser
    850                 855                 860                 
Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro
865                 870                 875                 880 
Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln
                885                 890                 895     
Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met
            900                 905                 910         
Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu
        915                 920                 925             
Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr
    930                 935                 940                 
Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly
945                 950                 955                 960 
Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu
                965                 970                 975     
Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile
            980                 985                 990         
Ser Cys Cys Thr Ala Gly Asn Gly Asn Ser Asp Ser Asn Leu Thr Thr
        995                 1000                1005            
Tyr Ser Arg Pro Ala Asp Cys Ile Ala Asn Tyr Asn Asn Gln Leu Asp
    1010                1015                1020                
Asn Lys Gln Thr Asn Leu Met Leu Pro Glu Ser Thr Val Tyr Gly Asp
1025                1030                1035                1040
Val Asp Leu Ser Asn Lys Ile Asn Glu Met Lys Thr Phe Asn Ser Pro
                1045                1050                1055    
Asn Leu Lys Asp Gly Arg Phe Val Asn Pro Ser Gly Gln Pro Thr Pro
            1060                1065                1070        
Tyr Ala Thr Thr Gln Leu Ile Gln Ser Asn Leu Ser Asn Asn Met Asn
        1075                1080                1085            
Asn Gly Ser Gly Asp Ser Gly Glu Lys His Trp Lys Pro Leu Gly Gln
    1090                1095                1100                
Gln Lys Gln Glu Val Ala Pro Val Gln Tyr Asn Ile Val Glu Gln Asn
1105                1110                1115                1120
Lys Leu Asn Lys Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile
                1125                1130                1135    
Pro Tyr Asn Gln Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser
            1140                1145                1150        
Ser Asp Arg Gly Ser Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly
        1155                1160                1165            
Ala Arg Thr Pro Lys Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp
    1170                1175                1180                
Leu Leu Pro Pro Pro Pro Ala His Pro Pro Pro His Ser Asn Ser Glu
1185                1190                1195                1200
Glu Tyr Asn Ile Ser Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys
                1205                1210                1215    
Pro Val Pro Pro Ala Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu
            1220                1225                1230        
Glu Glu Asp Glu Arg Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser
        1235                1240                1245            
Ser Pro Ala Ala Val Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr
    1250                1255                1260                
Pro Ser Pro Gln Glu Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu
1265                1270                1275                1280
Glu Thr Gly His Met Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val
                1285                1290                1295    
Ser Pro Pro Pro Pro Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly
            1300                1305                1310        
Tyr Ile Ser Gly Pro Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu
        1315                1320                1325            
Glu Glu Glu Asp Glu Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg
    1330                1335                1340                
Arg Leu Leu Leu Arg Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly
1345                1350                1355                1360
Asp Leu Glu Ser Ser Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser
                1365                1370                1375    
Ala Ser Glu Glu Asp Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser
            1380                1385                1390        
Ser Asp Gly Ser Phe Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala
        1395                1400                1405            
Ala Ala Ala Glu Tyr Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln
    1410                1415                1420                
Asp Ala Ala Gly Arg Arg His Phe His Ala Ser Gln Cys Pro Arg Pro
1425                1430                1435                1440
Thr Ser Pro Val Ser Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln
                1445                1450                1455    
Lys Thr Arg Pro Ala Lys Lys Leu Lys His Gln Pro Gly His Leu Arg
            1460                1465                1470        
Arg Glu Thr Tyr Thr Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro
        1475                1480                1485            
Ala Ile Lys Ser Pro Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg
    1490                1495                1500                
Pro Val Val Val Pro Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg
1505                1510                1515                1520
Ser Ser Asp Arg Lys Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp
                1525                1530                1535    
Gly Arg Gln Val Val Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu
            1540                1545                1550        
Ala Gln Glu Gln Gln Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala
        1555                1560                1565            
Lys Arg Asp Leu Pro Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile
    1570                1575                1580                
Leu Pro Tyr Cys Arg Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp
1585                1590                1595                1600
Pro Ser Ser Ser Ser Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln
                1605                1610                1615    
Arg Glu Gln Ala Asn Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val
            1620                1625                1630        
Leu Gly Gly Tyr Glu Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu
        1635                1640                1645            
Thr Glu Ser
    1650    


<210> 8982
<211> 356
<212> PRT
<213> Homo sapiens

<400> 8982
Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe
 1               5                  10                  15      
Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro
            20                  25                  30          
Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro
        35                  40                  45              
Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys
    50                  55                  60                  
Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val
65                  70                  75                  80  
Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp Asp Ala
                85                  90                  95      
Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe Val Leu Asp Arg
            100                 105                 110         
Ile Phe Val Cys Asp Lys His Lys Ile Leu Phe Cys Gln Thr Pro Lys
        115                 120                 125             
Val Gly Asn Thr Gln Trp Lys Lys Val Leu Ile Val Leu Asn Gly Ala
    130                 135                 140                 
Phe Ser Ser Ile Glu Glu Ile Pro Glu Asn Val Val His Asp His Glu
145                 150                 155                 160 
Lys Asn Gly Leu Pro Arg Leu Ser Ser Phe Ser Asp Ala Glu Ile Gln
                165                 170                 175     
Lys Arg Leu Lys Thr Tyr Phe Lys Phe Phe Ile Val Arg Asp Pro Phe
            180                 185                 190         
Glu Arg Leu Ile Ser Ala Phe Lys Asp Lys Phe Val His Asn Pro Arg
        195                 200                 205             
Phe Glu Pro Trp Tyr Arg His Glu Ile Ala Pro Gly Ile Ile Arg Lys
    210                 215                 220                 
Tyr Arg Arg Asn Arg Thr Glu Thr Arg Gly Ile Gln Phe Glu Asp Phe
225                 230                 235                 240 
Val Arg Tyr Leu Gly Asp Pro Asn His Arg Trp Leu Asp Leu Gln Phe
                245                 250                 255     
Gly Asp His Ile Ile His Trp Val Thr Tyr Val Glu Leu Cys Ala Pro
            260                 265                 270         
Cys Glu Ile Met Tyr Ser Val Ile Gly His His Glu Thr Leu Glu Asp
        275                 280                 285             
Asp Ala Pro Tyr Ile Leu Lys Glu Ala Gly Ile Asp His Leu Val Ser
    290                 295                 300                 
Tyr Pro Thr Ile Pro Pro Gly Ile Thr Val Tyr Asn Arg Thr Lys Val
305                 310                 315                 320 
Glu His Tyr Phe Leu Gly Ile Ser Lys Arg Asp Ile Arg Arg Leu Tyr
                325                 330                 335     
Ala Arg Phe Glu Gly Asp Phe Lys Leu Phe Gly Tyr Gln Lys Pro Asp
            340                 345                 350         
Phe Leu Leu Asn
        355     


<210> 8983
<211> 2653
<212> PRT
<213> Homo sapiens

<400> 8983
Met Val Ser Pro Pro Leu Leu Ile Ile Ser Val Ala Gly Thr Ile Glu
 1               5                  10                  15      
Cys Lys Pro Asp His Leu Leu Trp Arg Pro Gly Ser Thr Ser Pro Gln
            20                  25                  30          
Ser Val Ser Phe Leu His Gly Lys Val Val Met Glu Ser Leu Gly Arg
        35                  40                  45              
Pro Ile Pro Pro Thr Ser Ser Pro Ser Leu Leu Pro Ser Ala Gln Leu
    50                  55                  60                  
Pro Ser Ser His Asn Pro Pro Pro Val Ser Cys Gln Met Pro Leu Leu
65                  70                  75                  80  
Asp Ser Asn Thr Ser His Gln Ile Met Asp Thr Asn Pro Asp Glu Glu
                85                  90                  95      
Phe Ser Pro Asn Ser Tyr Leu Leu Arg Ala Cys Ser Gly Pro Gln Gln
            100                 105                 110         
Ala Ser Ser Ser Gly Pro Pro Asn His His Ser Gln Ser Thr Leu Arg
        115                 120                 125             
Pro Pro Leu Pro Pro Pro His Asn His Thr Leu Ser His His His Ser
    130                 135                 140                 
Ser Ala Asn Ser Leu Asn Arg Asn Ser Leu Thr Asn Arg Arg Ser Gln
145                 150                 155                 160 
Ile His Ala Pro Ala Pro Ala Pro Asn Asp Leu Ala Thr Thr Pro Glu
                165                 170                 175     
Ser Val Gln Leu Gln Asp Ser Trp Val Leu Asn Ser Asn Val Pro Leu
            180                 185                 190         
Glu Thr Arg His Phe Leu Phe Lys Thr Ser Ser Gly Ser Thr Pro Leu
        195                 200                 205             
Phe Ser Ser Ser Ser Pro Gly Tyr Pro Leu Thr Ser Gly Thr Val Tyr
    210                 215                 220                 
Thr Pro Pro Pro Arg Leu Leu Pro Arg Asn Thr Phe Ser Arg Lys Ala
225                 230                 235                 240 
Phe Lys Leu Lys Lys Pro Ser Lys Tyr Cys Ser Trp Lys Cys Ala Ala
                245                 250                 255     
Leu Ser Ala Ile Ala Ala Ala Leu Leu Leu Ala Ile Leu Leu Ala Tyr
            260                 265                 270         
Phe Ile Ala Met His Leu Leu Gly Leu Asn Trp Gln Leu Gln Pro Ala
        275                 280                 285             
Asp Gly His Thr Phe Asn Asn Gly Ile Arg Thr Gly Leu Pro Gly Asn
    290                 295                 300                 
Asp Asp Val Ala Thr Met Pro Ser Gly Gly Lys Val Pro Trp Ser Leu
305                 310                 315                 320 
Lys Asn Ser Ser Ile Asp Ser Gly Glu Ala Glu Val Gly Arg Arg Val
                325                 330                 335     
Thr Gln Glu Val Pro Pro Gly Val Phe Trp Arg Ser Gln Ile His Ile
            340                 345                 350         
Ser Gln Pro Gln Phe Leu Lys Phe Asn Ile Ser Leu Gly Lys Asp Ala
        355                 360                 365             
Leu Phe Gly Val Tyr Ile Arg Arg Gly Leu Pro Pro Ser His Ala Gln
    370                 375                 380                 
Tyr Asp Phe Met Glu Arg Leu Asp Gly Lys Glu Lys Trp Ser Val Val
385                 390                 395                 400 
Glu Ser Pro Arg Glu Arg Arg Ser Ile Gln Thr Leu Val Gln Asn Glu
                405                 410                 415     
Ala Val Phe Val Gln Tyr Leu Asp Val Gly Leu Trp His Leu Ala Phe
            420                 425                 430         
Tyr Asn Asp Gly Lys Asp Lys Glu Met Val Ser Phe Asn Thr Val Val
        435                 440                 445             
Leu Asp Ser Val Gln Asp Cys Pro Arg Asn Cys His Gly Asn Gly Glu
    450                 455                 460                 
Cys Val Ser Gly Val Cys His Cys Phe Pro Gly Phe Leu Gly Ala Asp
465                 470                 475                 480 
Cys Ala Lys Ala Ala Cys Pro Val Leu Cys Ser Gly Asn Gly Gln Tyr
                485                 490                 495     
Ser Lys Gly Thr Cys Gln Cys Tyr Ser Gly Trp Lys Gly Ala Glu Cys
            500                 505                 510         
Asp Val Pro Met Asn Gln Cys Ile Asp Pro Ser Cys Gly Gly His Gly
        515                 520                 525             
Ser Cys Ile Asp Gly Asn Cys Val Cys Ser Ala Gly Tyr Lys Gly Glu
    530                 535                 540                 
His Cys Glu Glu Val Asp Cys Leu Asp Pro Thr Cys Ser Ser His Gly
545                 550                 555                 560 
Val Cys Val Asn Gly Glu Cys Leu Cys Ser Pro Gly Trp Gly Gly Leu
                565                 570                 575     
Asn Cys Glu Leu Ala Arg Val Gln Cys Pro Asp Gln Cys Ser Gly His
            580                 585                 590         
Gly Thr Tyr Leu Pro Asp Thr Gly Leu Cys Ser Cys Asp Pro Asn Trp
        595                 600                 605             
Met Gly Pro Asp Cys Ser Val Glu Val Cys Ser Val Asp Cys Gly Thr
    610                 615                 620                 
His Gly Val Cys Ile Gly Gly Ala Cys Arg Cys Glu Glu Gly Trp Thr
625                 630                 635                 640 
Gly Ala Ala Cys Asp Gln Arg Val Cys His Pro Arg Cys Ile Glu His
                645                 650                 655     
Gly Thr Cys Lys Asp Gly Lys Cys Glu Cys Arg Glu Gly Trp Asn Gly
            660                 665                 670         
Glu His Cys Thr Ile Gly Arg Gln Thr Ala Gly Thr Glu Thr Asp Gly
        675                 680                 685             
Cys Pro Asp Leu Cys Asn Gly Asn Gly Arg Cys Thr Leu Gly Gln Asn
    690                 695                 700                 
Ser Trp Gln Cys Val Cys Gln Thr Gly Trp Arg Gly Pro Gly Cys Asn
705                 710                 715                 720 
Val Ala Met Glu Thr Ser Cys Ala Asp Asn Lys Asp Asn Glu Gly Asp
                725                 730                 735     
Gly Leu Val Asp Cys Leu Asp Pro Asp Cys Cys Leu Gln Ser Ala Cys
            740                 745                 750         
Gln Asn Ser Leu Leu Cys Arg Gly Ser Arg Asp Pro Leu Asp Ile Ile
        755                 760                 765             
Gln Gln Gly Gln Thr Asp Trp Pro Ala Val Lys Ser Phe Tyr Asp Arg
    770                 775                 780                 
Ile Lys Leu Leu Ala Gly Lys Asp Ser Thr His Ile Ile Pro Gly Glu
785                 790                 795                 800 
Asn Pro Phe Asn Ser Ser Leu Val Ser Leu Ile Arg Gly Gln Val Val
                805                 810                 815     
Thr Thr Asp Gly Thr Pro Leu Val Gly Val Asn Val Ser Phe Val Lys
            820                 825                 830         
Tyr Pro Lys Tyr Gly Tyr Thr Ile Thr Arg Gln Asp Gly Thr Phe Asp
        835                 840                 845             
Leu Ile Ala Asn Gly Gly Ala Ser Leu Thr Leu His Phe Glu Arg Ala
    850                 855                 860                 
Pro Phe Met Ser Gln Glu Arg Thr Val Trp Leu Pro Trp Asn Ser Phe
865                 870                 875                 880 
Tyr Ala Met Asp Thr Leu Val Met Lys Thr Glu Glu Asn Ser Ile Pro
                885                 890                 895     
Ser Cys Asp Leu Ser Gly Phe Val Arg Pro Asp Pro Ile Ile Ile Ser
            900                 905                 910         
Ser Pro Leu Ser Thr Phe Phe Ser Ala Ala Pro Gly Gln Asn Pro Ile
        915                 920                 925             
Val Pro Glu Thr Gln Val Leu His Glu Glu Ile Glu Leu Pro Gly Ser
    930                 935                 940                 
Asn Val Lys Leu Arg Tyr Leu Ser Ser Arg Thr Ala Gly Tyr Lys Ser
945                 950                 955                 960 
Leu Leu Lys Ile Thr Met Thr Gln Ser Thr Val Pro Leu Asn Leu Ile
                965                 970                 975     
Arg Val His Leu Met Val Ala Val Glu Gly His Leu Phe Gln Lys Ser
            980                 985                 990         
Phe Gln Ala Ser Pro Asn Leu Ala Tyr Thr Phe Ile Trp Asp Lys Thr
        995                 1000                1005            
Asp Ala Tyr Gly Gln Arg Val Tyr Gly Leu Ser Asp Ala Val Val Ser
    1010                1015                1020                
Val Gly Phe Glu Tyr Glu Thr Cys Pro Ser Leu Ile Leu Trp Glu Lys
1025                1030                1035                1040
Arg Thr Ala Leu Leu Gln Gly Phe Glu Leu Asp Pro Ser Asn Leu Gly
                1045                1050                1055    
Gly Trp Ser Leu Asp Lys His His Ile Leu Asn Val Lys Ser Gly Ile
            1060                1065                1070        
Leu His Lys Gly Thr Gly Glu Asn Gln Phe Leu Thr Gln Gln Pro Ala
        1075                1080                1085            
Ile Ile Thr Ser Ile Met Gly Asn Gly Arg Arg Arg Ser Ile Ser Cys
    1090                1095                1100                
Pro Ser Cys Asn Gly Leu Ala Glu Gly Asn Lys Leu Leu Ala Pro Val
1105                1110                1115                1120
Ala Leu Ala Val Gly Ile Asp Gly Ser Leu Tyr Val Gly Asp Phe Asn
                1125                1130                1135    
Tyr Ile Arg Arg Ile Phe Pro Ser Arg Asn Val Thr Ser Ile Leu Glu
            1140                1145                1150        
Leu Arg Asn Lys Glu Phe Lys His Ser Asn Asn Pro Ala His Lys Tyr
        1155                1160                1165            
Tyr Leu Ala Val Asp Pro Val Ser Gly Ser Leu Tyr Val Ser Asp Thr
    1170                1175                1180                
Asn Ser Arg Arg Ile Tyr Arg Val Lys Ser Leu Ser Gly Thr Lys Asp
1185                1190                1195                1200
Leu Ala Gly Asn Ser Glu Val Val Ala Gly Thr Gly Glu Gln Cys Leu
                1205                1210                1215    
Pro Phe Asp Glu Ala Arg Cys Gly Asp Gly Gly Lys Ala Ile Asp Ala
            1220                1225                1230        
Thr Leu Met Ser Pro Arg Gly Ile Ala Val Asp Lys Asn Gly Leu Met
        1235                1240                1245            
Tyr Phe Val Asp Ala Thr Met Ile Arg Lys Val Asp Gln Asn Gly Ile
    1250                1255                1260                
Ile Ser Thr Leu Leu Gly Ser Asn Asp Leu Thr Ala Val Arg Pro Leu
1265                1270                1275                1280
Ser Cys Asp Ser Ser Met Asp Val Ala Gln Val Arg Leu Glu Trp Pro
                1285                1290                1295    
Thr Asp Leu Ala Val Asn Pro Met Asp Asn Ser Leu Tyr Val Leu Glu
            1300                1305                1310        
Asn Asn Val Ile Leu Arg Ile Thr Glu Asn His Gln Val Ser Ile Ile
        1315                1320                1325            
Ala Gly Arg Pro Met His Cys Gln Val Pro Gly Ile Asp Tyr Ser Leu
    1330                1335                1340                
Ser Lys Leu Ala Ile His Ser Ala Leu Glu Ser Ala Ser Ala Ile Ala
1345                1350                1355                1360
Ile Ser His Thr Gly Val Leu Tyr Ile Thr Glu Thr Asp Glu Lys Lys
                1365                1370                1375    
Ile Asn Arg Leu Arg Gln Val Thr Thr Asn Gly Glu Ile Cys Leu Leu
            1380                1385                1390        
Ala Gly Ala Ala Ser Asp Cys Asp Cys Lys Asn Asp Val Asn Cys Asn
        1395                1400                1405            
Cys Tyr Ser Gly Asp Asp Ala Tyr Ala Thr Asp Ala Ile Leu Asn Ser
    1410                1415                1420                
Pro Ser Ser Leu Ala Val Ala Pro Asp Gly Thr Ile Tyr Ile Ala Asp
1425                1430                1435                1440
Leu Gly Asn Ile Arg Ile Arg Ala Val Ser Lys Asn Lys Pro Val Leu
                1445                1450                1455    
Asn Ala Phe Asn Gln Tyr Glu Ala Ala Ser Pro Gly Glu Gln Glu Leu
            1460                1465                1470        
Tyr Val Phe Asn Ala Asp Gly Ile His Gln Tyr Thr Val Ser Leu Val
        1475                1480                1485            
Thr Gly Glu Tyr Leu Tyr Asn Phe Thr Tyr Ser Thr Asp Asn Asp Val
    1490                1495                1500                
Thr Glu Leu Ile Asp Asn Asn Gly Asn Ser Leu Lys Ile Arg Arg Asp
1505                1510                1515                1520
Ser Ser Gly Met Pro Arg His Leu Leu Met Pro Asp Asn Gln Ile Ile
                1525                1530                1535    
Thr Leu Thr Val Gly Thr Asn Gly Gly Leu Lys Val Val Ser Thr Gln
            1540                1545                1550        
Asn Leu Glu Leu Gly Leu Met Thr Tyr Asp Gly Asn Thr Gly Leu Leu
        1555                1560                1565            
Ala Thr Lys Ser Asp Glu Thr Gly Trp Thr Thr Phe Tyr Asp Tyr Asp
    1570                1575                1580                
His Glu Gly Arg Leu Thr Asn Val Thr Arg Pro Thr Gly Val Val Thr
1585                1590                1595                1600
Ser Leu His Arg Glu Met Glu Lys Ser Ile Thr Ile Asp Ile Glu Asn
                1605                1610                1615    
Ser Asn Arg Asp Asp Asp Val Thr Val Ile Thr Asn Leu Ser Ser Val
            1620                1625                1630        
Glu Ala Ser Tyr Thr Val Val Gln Asp Gln Val Arg Asn Ser Tyr Gln
        1635                1640                1645            
Leu Cys Asn Asn Gly Thr Leu Arg Val Met Tyr Ala Asn Gly Met Gly
    1650                1655                1660                
Ile Ser Phe His Ser Glu Pro His Val Leu Ala Gly Thr Ile Thr Pro
1665                1670                1675                1680
Thr Ile Gly Arg Cys Asn Ile Ser Leu Pro Met Glu Asn Gly Leu Asn
                1685                1690                1695    
Ser Ile Glu Trp Arg Leu Arg Lys Glu Gln Ile Lys Gly Lys Val Thr
            1700                1705                1710        
Ile Phe Gly Arg Lys Leu Arg Val His Gly Arg Asn Leu Leu Ser Ile
        1715                1720                1725            
Asp Tyr Asp Arg Asn Ile Arg Thr Glu Lys Ile Tyr Asp Asp His Arg
    1730                1735                1740                
Lys Phe Thr Leu Arg Ile Ile Tyr Asp Gln Val Gly Arg Pro Phe Leu
1745                1750                1755                1760
Trp Leu Pro Ser Ser Gly Leu Ala Ala Val Asn Val Ser Tyr Phe Phe
                1765                1770                1775    
Asn Gly Arg Leu Ala Gly Leu Gln Arg Gly Ala Met Ser Glu Arg Thr
            1780                1785                1790        
Asp Ile Asp Lys Gln Gly Arg Ile Val Ser Arg Met Phe Ala Asp Gly
        1795                1800                1805            
Lys Val Trp Ser Tyr Ser Tyr Leu Asp Lys Ser Met Val Leu Leu Leu
    1810                1815                1820                
Gln Ser Gln Arg Gln Tyr Ile Phe Glu Tyr Asp Ser Ser Asp Arg Leu
1825                1830                1835                1840
Leu Ala Val Thr Met Pro Ser Val Ala Arg His Ser Met Ser Thr His
                1845                1850                1855    
Thr Ser Ile Gly Tyr Ile Arg Asn Ile Tyr Asn Pro Pro Glu Ser Asn
            1860                1865                1870        
Ala Ser Val Ile Phe Asp Tyr Ser Asp Asp Gly Arg Ile Leu Lys Thr
        1875                1880                1885            
Ser Phe Leu Gly Thr Gly Arg Gln Val Phe Tyr Lys Tyr Gly Lys Leu
    1890                1895                1900                
Ser Lys Leu Ser Glu Ile Val Tyr Asp Ser Thr Ala Val Thr Phe Gly
1905                1910                1915                1920
Tyr Asp Glu Thr Thr Gly Val Leu Lys Met Val Asn Leu Gln Ser Gly
                1925                1930                1935    
Gly Phe Ser Cys Thr Ile Arg Tyr Arg Lys Ile Gly Pro Leu Val Asp
            1940                1945                1950        
Lys Gln Ile Tyr Arg Phe Ser Glu Glu Gly Met Val Asn Ala Arg Phe
        1955                1960                1965            
Asp Tyr Thr Tyr His Asp Asn Ser Phe Arg Ile Ala Ser Ile Lys Pro
    1970                1975                1980                
Val Ile Ser Glu Thr Pro Leu Pro Val Asp Leu Tyr Arg Tyr Asp Glu
1985                1990                1995                2000
Ile Ser Gly Lys Val Glu His Phe Gly Lys Phe Gly Val Ile Tyr Tyr
                2005                2010                2015    
Asp Ile Asn Gln Ile Ile Thr Thr Ala Val Met Thr Leu Ser Lys His
            2020                2025                2030        
Phe Asp Thr His Gly Arg Ile Lys Glu Val Gln Tyr Glu Met Phe Arg
        2035                2040                2045            
Ser Leu Met Tyr Trp Met Thr Val Gln Tyr Asp Ser Met Gly Arg Val
    2050                2055                2060                
Ile Lys Arg Glu Leu Lys Leu Gly Pro Tyr Ala Asn Thr Thr Lys Tyr
2065                2070                2075                2080
Thr Tyr Asp Tyr Asp Gly Asp Gly Gln Leu Gln Ser Val Ala Val Asn
                2085                2090                2095    
Asp Arg Pro Thr Trp Arg Tyr Ser Tyr Asp Leu Asn Gly Asn Leu His
            2100                2105                2110        
Leu Leu Asn Pro Gly Asn Ser Val Arg Leu Met Pro Leu Arg Tyr Asp
        2115                2120                2125            
Leu Arg Asp Arg Ile Thr Arg Leu Gly Asp Val Gln Tyr Lys Ile Asp
    2130                2135                2140                
Asp Asp Gly Tyr Leu Cys Gln Arg Gly Ser Asp Ile Phe Glu Tyr Asn
2145                2150                2155                2160
Ser Lys Gly Leu Leu Thr Arg Ala Tyr Asn Lys Ala Ser Gly Trp Ser
                2165                2170                2175    
Val Gln Tyr Arg Tyr Asp Gly Val Gly Arg Arg Ala Ser Tyr Lys Thr
            2180                2185                2190        
Asn Leu Gly His His Leu Gln Tyr Phe Tyr Ser Asp Leu His Asn Pro
        2195                2200                2205            
Thr Arg Ile Thr His Val Tyr Asn His Ser Asn Ser Glu Ile Thr Ser
    2210                2215                2220                
Leu Tyr Tyr Asp Leu Gln Gly His Leu Phe Ala Met Glu Ser Ser Ser
2225                2230                2235                2240
Gly Glu Glu Tyr Tyr Val Ala Ser Asp Asn Thr Gly Thr Pro Leu Ala
                2245                2250                2255    
Val Phe Ser Ile Asn Gly Leu Met Ile Lys Gln Leu Gln Tyr Thr Ala
            2260                2265                2270        
Tyr Gly Glu Ile Tyr Tyr Asp Ser Asn Pro Asp Phe Gln Met Val Ile
        2275                2280                2285            
Gly Phe His Gly Gly Leu Tyr Asp Pro Leu Thr Lys Leu Val His Phe
    2290                2295                2300                
Thr Gln Arg Asp Tyr Asp Val Leu Ala Gly Arg Trp Thr Ser Pro Asp
2305                2310                2315                2320
Tyr Thr Met Trp Lys Asn Val Gly Lys Glu Pro Ala Pro Phe Asn Leu
                2325                2330                2335    
Tyr Met Phe Lys Ser Asn Asn Pro Leu Ser Ser Glu Leu Asp Leu Lys
            2340                2345                2350        
Asn Tyr Val Thr Asp Val Lys Ser Trp Leu Val Met Phe Gly Phe Gln
        2355                2360                2365            
Leu Ser Asn Ile Ile Pro Gly Phe Pro Arg Ala Lys Met Tyr Phe Val
    2370                2375                2380                
Pro Pro Pro Tyr Glu Leu Ser Glu Ser Gln Ala Ser Glu Asn Gly Gln
2385                2390                2395                2400
Leu Ile Thr Gly Val Gln Gln Thr Thr Glu Arg His Asn Gln Ala Phe
                2405                2410                2415    
Met Ala Leu Glu Gly Gln Val Ile Thr Lys Lys Leu His Ala Ser Ile
            2420                2425                2430        
Arg Glu Lys Ala Gly His Trp Phe Ala Thr Thr Thr Pro Ile Ile Gly
        2435                2440                2445            
Lys Gly Ile Met Phe Ala Ile Lys Glu Gly Arg Val Thr Thr Gly Val
    2450                2455                2460                
Ser Ser Ile Ala Ser Glu Asp Ser Arg Lys Val Ala Ser Val Leu Asn
2465                2470                2475                2480
Asn Ala Tyr Tyr Leu Asp Lys Met His Tyr Ser Ile Glu Gly Lys Asp
                2485                2490                2495    
Thr His Tyr Phe Val Lys Ile Gly Ser Ala Asp Gly Asp Leu Val Thr
            2500                2505                2510        
Leu Gly Thr Thr Ile Gly Arg Lys Val Leu Glu Ser Gly Val Asn Val
        2515                2520                2525            
Thr Val Ser Gln Pro Thr Leu Leu Val Asn Gly Arg Thr Arg Arg Phe
    2530                2535                2540                
Thr Asn Ile Glu Phe Gln Tyr Ser Thr Leu Leu Leu Ser Ile Arg Tyr
2545                2550                2555                2560
Gly Leu Thr Pro Asp Thr Leu Asp Glu Glu Lys Ala Arg Val Leu Asp
                2565                2570                2575    
Gln Ala Arg Gln Arg Ala Leu Gly Thr Ala Trp Ala Lys Glu Gln Gln
            2580                2585                2590        
Lys Ala Arg Asp Gly Arg Glu Gly Ser Arg Leu Trp Thr Glu Gly Glu
        2595                2600                2605            
Lys Gln Gln Leu Leu Ser Thr Gly Arg Val Gln Gly Tyr Glu Gly Tyr
    2610                2615                2620                
Tyr Val Leu Pro Val Glu Gln Tyr Pro Glu Leu Ala Asp Ser Ser Ser
2625                2630                2635                2640
Asn Ile Gln Phe Leu Arg Gln Asn Glu Met Gly Lys Arg
                2645                2650            


<210> 8984
<211> 4655
<212> PRT
<213> Homo sapiens

<400> 8984
Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu
 1               5                  10                  15      
Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His
            20                  25                  30          
Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp
        35                  40                  45              
Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val
    50                  55                  60                  
Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys
65                  70                  75                  80  
Ile Pro Ser Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly
                85                  90                  95      
Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln
            100                 105                 110         
Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp
        115                 120                 125             
His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr
    130                 135                 140                 
Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr
145                 150                 155                 160 
Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu
                165                 170                 175     
Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn
            180                 185                 190         
Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys
        195                 200                 205             
Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly
    210                 215                 220                 
Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val
225                 230                 235                 240 
Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys
                245                 250                 255     
Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser
            260                 265                 270         
Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly
        275                 280                 285             
Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly
    290                 295                 300                 
Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln
305                 310                 315                 320 
Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr
                325                 330                 335     
Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys
            340                 345                 350         
Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg
        355                 360                 365             
His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr
    370                 375                 380                 
Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn
385                 390                 395                 400 
Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile
                405                 410                 415     
Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His
            420                 425                 430         
Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val
        435                 440                 445             
Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val
    450                 455                 460                 
Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys
465                 470                 475                 480 
Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu
                485                 490                 495     
Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro
            500                 505                 510         
Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp
        515                 520                 525             
Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp
    530                 535                 540                 
Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala
545                 550                 555                 560 
Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser
                565                 570                 575     
Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys
            580                 585                 590         
Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser
        595                 600                 605             
Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val
    610                 615                 620                 
Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln
625                 630                 635                 640 
Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln
                645                 650                 655     
Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln
            660                 665                 670         
Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg
        675                 680                 685             
Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys
    690                 695                 700                 
Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg
705                 710                 715                 720 
Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val
                725                 730                 735     
Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp
            740                 745                 750         
Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln
        755                 760                 765             
Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu
    770                 775                 780                 
Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp
785                 790                 795                 800 
Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys
                805                 810                 815     
Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val
            820                 825                 830         
Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro
        835                 840                 845             
Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val
    850                 855                 860                 
Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala
865                 870                 875                 880 
Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His
                885                 890                 895     
Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln
            900                 905                 910         
Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe
        915                 920                 925             
Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly
    930                 935                 940                 
Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu
945                 950                 955                 960 
Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln
                965                 970                 975     
Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro
            980                 985                 990         
Asn Phe Gln Arg Val Cys Gly Cys Pro Tyr Gly Met Arg Leu Ala Ser
        995                 1000                1005            
Asn His Leu Thr Cys Glu Gly Asp Pro Thr Asn Glu Pro Pro Thr Glu
    1010                1015                1020                
Gln Cys Gly Leu Phe Ser Phe Pro Cys Lys Asn Gly Arg Cys Val Pro
1025                1030                1035                1040
Asn Tyr Tyr Leu Cys Asp Gly Val Asp Asp Cys His Asp Asn Ser Asp
                1045                1050                1055    
Glu Gln Leu Cys Gly Thr Leu Asn Asn Thr Cys Ser Ser Ser Ala Phe
            1060                1065                1070        
Thr Cys Gly His Gly Glu Cys Ile Pro Ala His Trp Arg Cys Asp Lys
        1075                1080                1085            
Arg Asn Asp Cys Val Asp Gly Ser Asp Glu His Asn Cys Pro Thr His
    1090                1095                1100                
Ala Pro Ala Ser Cys Leu Asp Thr Gln Tyr Thr Cys Asp Asn His Gln
1105                1110                1115                1120
Cys Ile Ser Lys Asn Trp Val Cys Asp Thr Asp Asn Asp Cys Gly Asp
                1125                1130                1135    
Gly Ser Asp Glu Lys Asn Cys Asn Ser Thr Glu Thr Cys Gln Pro Ser
            1140                1145                1150        
Gln Phe Asn Cys Pro Asn His Arg Cys Ile Asp Leu Ser Phe Val Cys
        1155                1160                1165            
Asp Gly Asp Lys Asp Cys Val Asp Gly Ser Asp Glu Val Gly Cys Val
    1170                1175                1180                
Leu Asn Cys Thr Ala Ser Gln Phe Lys Cys Ala Ser Gly Asp Lys Cys
1185                1190                1195                1200
Ile Gly Val Thr Asn Arg Cys Asp Gly Val Phe Asp Cys Ser Asp Asn
                1205                1210                1215    
Ser Asp Glu Ala Gly Cys Pro Thr Arg Pro Pro Gly Met Cys His Ser
            1220                1225                1230        
Asp Glu Phe Gln Cys Gln Glu Asp Gly Ile Cys Ile Pro Asn Phe Trp
        1235                1240                1245            
Glu Cys Asp Gly His Pro Asp Cys Leu Tyr Gly Ser Asp Glu His Asn
    1250                1255                1260                
Ala Cys Val Pro Lys Thr Cys Pro Ser Ser Tyr Phe His Cys Asp Asn
1265                1270                1275                1280
Gly Asn Cys Ile His Arg Ala Trp Leu Cys Asp Arg Asp Asn Asp Cys
                1285                1290                1295    
Gly Asp Met Ser Asp Glu Lys Asp Cys Pro Thr Gln Pro Phe Arg Cys
            1300                1305                1310        
Pro Ser Trp Gln Trp Gln Cys Leu Gly His Asn Ile Cys Val Asn Leu
        1315                1320                1325            
Ser Val Val Cys Asp Gly Ile Phe Asp Cys Pro Asn Gly Thr Asp Glu
    1330                1335                1340                
Ser Pro Leu Cys Asn Gly Asn Ser Cys Ser Asp Phe Asn Gly Gly Cys
1345                1350                1355                1360
Thr His Glu Cys Val Gln Glu Pro Phe Gly Ala Lys Cys Leu Cys Pro
                1365                1370                1375    
Leu Gly Phe Leu Leu Ala Asn Asp Ser Lys Thr Cys Glu Asp Ile Asp
            1380                1385                1390        
Glu Cys Asp Ile Leu Gly Ser Cys Ser Gln His Cys Tyr Asn Met Arg
        1395                1400                1405            
Gly Ser Phe Arg Cys Ser Cys Asp Thr Gly Tyr Met Leu Glu Ser Asp
    1410                1415                1420                
Gly Arg Thr Cys Lys Val Thr Ala Ser Glu Ser Leu Leu Leu Leu Val
1425                1430                1435                1440
Ala Ser Gln Asn Lys Ile Ile Ala Asp Ser Val Thr Ser Gln Val His
                1445                1450                1455    
Asn Ile Tyr Ser Leu Val Glu Asn Gly Ser Tyr Ile Val Ala Val Asp
            1460                1465                1470        
Phe Asp Ser Ile Ser Gly Arg Ile Phe Trp Ser Asp Ala Thr Gln Gly
        1475                1480                1485            
Lys Thr Trp Ser Ala Phe Gln Asn Gly Thr Asp Arg Arg Val Val Phe
    1490                1495                1500                
Asp Ser Ser Ile Ile Leu Thr Glu Thr Ile Ala Ile Asp Trp Val Gly
1505                1510                1515                1520
Arg Asn Leu Tyr Trp Thr Asp Tyr Ala Leu Glu Thr Ile Glu Val Ser
                1525                1530                1535    
Lys Ile Asp Gly Ser His Arg Thr Val Leu Ile Ser Lys Asn Leu Thr
            1540                1545                1550        
Asn Pro Arg Gly Leu Ala Leu Asp Pro Arg Met Asn Glu His Leu Leu
        1555                1560                1565            
Phe Trp Ser Asp Trp Gly His His Pro Arg Ile Glu Arg Ala Ser Met
    1570                1575                1580                
Asp Gly Ser Met Arg Thr Val Ile Val Gln Asp Lys Ile Phe Trp Pro
1585                1590                1595                1600
Cys Gly Leu Thr Ile Asp Tyr Pro Asn Arg Leu Leu Tyr Phe Met Asp
                1605                1610                1615    
Ser Tyr Leu Asp Tyr Met Asp Phe Cys Asp Tyr Asn Gly His His Arg
            1620                1625                1630        
Arg Gln Val Ile Ala Ser Asp Leu Ile Ile Arg His Pro Tyr Ala Leu
        1635                1640                1645            
Thr Leu Phe Glu Asp Ser Val Tyr Trp Thr Asp Arg Ala Thr Arg Arg
    1650                1655                1660                
Val Met Arg Ala Asn Lys Trp His Gly Gly Asn Gln Ser Val Val Met
1665                1670                1675                1680
Tyr Asn Ile Gln Trp Pro Leu Gly Ile Val Ala Val His Pro Ser Lys
                1685                1690                1695    
Gln Pro Asn Ser Val Asn Pro Cys Ala Phe Ser Arg Cys Ser His Leu
            1700                1705                1710        
Cys Leu Leu Ser Ser Gln Gly Pro His Phe Tyr Ser Cys Val Cys Pro
        1715                1720                1725            
Ser Gly Trp Ser Leu Ser Pro Asp Leu Leu Asn Cys Leu Arg Asp Asp
    1730                1735                1740                
Gln Pro Phe Leu Ile Thr Val Arg Gln His Ile Ile Phe Gly Ile Ser
1745                1750                1755                1760
Leu Asn Pro Glu Val Lys Ser Asn Asp Ala Met Val Pro Ile Ala Gly
                1765                1770                1775    
Ile Gln Asn Gly Leu Asp Val Glu Phe Asp Asp Ala Glu Gln Tyr Ile
            1780                1785                1790        
Tyr Trp Val Glu Asn Pro Gly Glu Ile His Arg Val Lys Thr Asp Gly
        1795                1800                1805            
Thr Asn Arg Thr Val Phe Ala Ser Ile Ser Met Val Gly Pro Ser Met
    1810                1815                1820                
Asn Leu Ala Leu Asp Trp Ile Ser Arg Asn Leu Tyr Ser Thr Asn Pro
1825                1830                1835                1840
Arg Thr Gln Ser Ile Glu Val Leu Thr Leu His Gly Asp Ile Arg Tyr
                1845                1850                1855    
Arg Lys Thr Leu Ile Ala Asn Asp Gly Thr Ala Leu Gly Val Gly Phe
            1860                1865                1870        
Pro Ile Gly Ile Thr Val Asp Pro Ala Arg Gly Lys Leu Tyr Trp Ser
        1875                1880                1885            
Asp Gln Gly Thr Asp Ser Gly Val Pro Ala Lys Ile Ala Ser Ala Asn
    1890                1895                1900                
Met Asp Gly Thr Ser Val Lys Thr Leu Phe Thr Gly Asn Leu Glu His
1905                1910                1915                1920
Leu Glu Cys Val Thr Leu Asp Ile Glu Glu Gln Lys Leu Tyr Trp Ala
                1925                1930                1935    
Val Thr Gly Arg Gly Val Ile Glu Arg Gly Asn Val Asp Gly Thr Asp
            1940                1945                1950        
Arg Met Ile Leu Val His Gln Leu Ser His Pro Trp Gly Ile Ala Val
        1955                1960                1965            
His Asp Ser Phe Leu Tyr Tyr Thr Asp Glu Gln Tyr Glu Val Ile Glu
    1970                1975                1980                
Arg Val Asp Lys Ala Thr Gly Ala Asn Lys Ile Val Leu Arg Asp Asn
1985                1990                1995                2000
Val Pro Asn Leu Arg Gly Leu Gln Val Tyr His Arg Arg Asn Ala Ala
                2005                2010                2015    
Glu Ser Ser Asn Gly Cys Ser Asn Asn Met Asn Ala Cys Gln Gln Ile
            2020                2025                2030        
Cys Leu Pro Val Pro Gly Gly Leu Phe Ser Cys Ala Cys Ala Thr Gly
        2035                2040                2045            
Phe Lys Leu Asn Pro Asp Asn Arg Ser Cys Ser Pro Tyr Asn Ser Phe
    2050                2055                2060                
Ile Val Val Ser Met Leu Ser Ala Ile Arg Gly Phe Ser Leu Glu Leu
2065                2070                2075                2080
Ser Asp His Ser Glu Thr Met Val Pro Val Ala Gly Gln Gly Arg Asn
                2085                2090                2095    
Ala Leu His Val Asp Val Asp Val Ser Ser Gly Phe Ile Tyr Trp Cys
            2100                2105                2110        
Asp Phe Ser Ser Ser Val Ala Ser Asp Asn Ala Ile Arg Arg Ile Lys
        2115                2120                2125            
Pro Asp Gly Ser Ser Leu Met Asn Ile Val Thr His Gly Ile Gly Glu
    2130                2135                2140                
Asn Gly Val Arg Gly Ile Ala Val Asp Trp Val Ala Gly Asn Leu Tyr
2145                2150                2155                2160
Phe Thr Asn Ala Phe Val Ser Glu Thr Leu Ile Glu Val Leu Arg Ile
                2165                2170                2175    
Asn Thr Thr Tyr Arg Arg Val Leu Leu Lys Val Thr Val Asp Met Pro
            2180                2185                2190        
Arg His Ile Val Val Asp Pro Lys Asn Arg Tyr Leu Phe Trp Ala Asp
        2195                2200                2205            
Tyr Gly Gln Arg Pro Lys Ile Glu Arg Ser Phe Leu Asp Cys Thr Asn
    2210                2215                2220                
Arg Thr Val Leu Val Ser Glu Gly Ile Val Thr Pro Arg Gly Leu Ala
2225                2230                2235                2240
Val Asp Arg Ser Asp Gly Tyr Val Tyr Trp Val Asp Asp Ser Leu Asp
                2245                2250                2255    
Ile Ile Ala Arg Ile Arg Ile Asn Gly Glu Asn Ser Glu Val Ile Arg
            2260                2265                2270        
Tyr Gly Ser Arg Tyr Pro Thr Pro Tyr Gly Ile Thr Val Phe Glu Asn
        2275                2280                2285            
Ser Ile Ile Trp Val Asp Arg Asn Leu Lys Lys Ile Phe Gln Ala Ser
    2290                2295                2300                
Lys Glu Pro Glu Asn Thr Glu Pro Pro Thr Val Ile Arg Asp Asn Ile
2305                2310                2315                2320
Asn Trp Leu Arg Asp Val Thr Ile Phe Asp Lys Gln Val Gln Pro Arg
                2325                2330                2335    
Ser Pro Ala Glu Val Asn Asn Asn Pro Cys Leu Glu Asn Asn Gly Gly
            2340                2345                2350        
Cys Ser His Leu Cys Phe Ala Leu Pro Gly Leu His Thr Pro Lys Cys
        2355                2360                2365            
Asp Cys Ala Phe Gly Thr Leu Gln Ser Asp Gly Lys Asn Cys Ala Ile
    2370                2375                2380                
Ser Thr Glu Asn Phe Leu Ile Phe Ala Leu Ser Asn Ser Leu Arg Ser
2385                2390                2395                2400
Leu His Leu Asp Pro Glu Asn His Ser Pro Pro Phe Gln Thr Ile Asn
                2405                2410                2415    
Val Glu Arg Thr Val Met Ser Leu Asp Tyr Asp Ser Val Ser Asp Arg
            2420                2425                2430        
Ile Tyr Phe Thr Gln Asn Leu Ala Ser Gly Val Gly Gln Ile Ser Tyr
        2435                2440                2445            
Ala Thr Leu Ser Ser Gly Ile His Thr Pro Thr Val Ile Ala Ser Gly
    2450                2455                2460                
Ile Gly Thr Ala Asp Gly Ile Ala Phe Asp Trp Ile Thr Arg Arg Ile
2465                2470                2475                2480
Tyr Tyr Ser Asp Tyr Leu Asn Gln Met Ile Asn Ser Met Ala Glu Asp
                2485                2490                2495    
Gly Ser Asn Arg Thr Val Ile Ala Arg Val Pro Lys Pro Arg Ala Ile
            2500                2505                2510        
Val Leu Asp Pro Cys Gln Gly Tyr Leu Tyr Trp Ala Asp Trp Asp Thr
        2515                2520                2525            
His Ala Lys Ile Glu Arg Ala Thr Leu Gly Gly Asn Phe Arg Val Pro
    2530                2535                2540                
Ile Val Asn Ser Ser Leu Val Met Pro Ser Gly Leu Thr Leu Asp Tyr
2545                2550                2555                2560
Glu Glu Asp Leu Leu Tyr Trp Val Asp Ala Ser Leu Gln Arg Ile Glu
                2565                2570                2575    
Arg Ser Thr Leu Thr Gly Val Asp Arg Glu Val Ile Val Asn Ala Ala
            2580                2585                2590        
Val His Ala Phe Gly Leu Thr Leu Tyr Gly Gln Tyr Ile Tyr Trp Thr
        2595                2600                2605            
Asp Leu Tyr Thr Gln Arg Ile Tyr Arg Ala Asn Lys Tyr Asp Gly Ser
    2610                2615                2620                
Gly Gln Ile Ala Met Thr Thr Asn Leu Leu Ser Gln Pro Arg Gly Ile
2625                2630                2635                2640
Asn Thr Val Val Lys Asn Gln Lys Gln Gln Cys Asn Asn Pro Cys Glu
                2645                2650                2655    
Gln Phe Asn Gly Gly Cys Ser His Ile Cys Ala Pro Gly Pro Asn Gly
            2660                2665                2670        
Ala Glu Cys Gln Cys Pro His Glu Gly Asn Trp Tyr Leu Ala Asn Asn
        2675                2680                2685            
Arg Lys His Cys Ile Val Asp Asn Gly Glu Arg Cys Gly Ala Ser Ser
    2690                2695                2700                
Phe Thr Cys Ser Asn Gly Arg Cys Ile Ser Glu Glu Trp Lys Cys Asp
2705                2710                2715                2720
Asn Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu Met Glu Ser Val Cys
                2725                2730                2735    
Ala Leu His Thr Cys Ser Pro Thr Ala Phe Thr Cys Ala Asn Gly Arg
            2740                2745                2750        
Cys Val Gln Tyr Ser Tyr Arg Cys Asp Tyr Tyr Asn Asp Cys Gly Asp
        2755                2760                2765            
Gly Ser Asp Glu Ala Gly Cys Leu Phe Arg Asp Cys Asn Ala Thr Thr
    2770                2775                2780                
Glu Phe Met Cys Asn Asn Arg Arg Cys Ile Pro Arg Glu Phe Ile Cys
2785                2790                2795                2800
Asn Gly Val Asp Asn Cys His Asp Asn Asn Thr Ser Asp Glu Lys Asn
                2805                2810                2815    
Cys Pro Asp Arg Thr Cys Gln Ser Gly Tyr Thr Lys Cys His Asn Ser
            2820                2825                2830        
Asn Ile Cys Ile Pro Arg Val Tyr Leu Cys Asp Gly Asp Asn Asp Cys
        2835                2840                2845            
Gly Asp Asn Ser Asp Glu Asn Pro Thr Tyr Cys Thr Thr His Thr Cys
    2850                2855                2860                
Ser Ser Ser Glu Phe Gln Cys Ala Ser Gly Arg Cys Ile Pro Gln His
2865                2870                2875                2880
Trp Tyr Cys Asp Gln Glu Thr Asp Cys Phe Asp Ala Ser Asp Glu Pro
                2885                2890                2895    
Ala Ser Cys Gly His Ser Glu Arg Thr Cys Leu Ala Asp Glu Phe Lys
            2900                2905                2910        
Cys Asp Gly Gly Arg Cys Ile Pro Ser Glu Trp Ile Cys Asp Gly Asp
        2915                2920                2925            
Asn Asp Cys Gly Asp Met Ser Asp Glu Asp Lys Arg His Gln Cys Gln
    2930                2935                2940                
Asn Gln Asn Cys Ser Asp Ser Glu Phe Leu Cys Val Asn Asp Arg Pro
2945                2950                2955                2960
Pro Asp Arg Arg Cys Ile Pro Gln Ser Trp Val Cys Asp Gly Asp Val
                2965                2970                2975    
Asp Cys Thr Asp Gly Tyr Asp Glu Asn Gln Asn Cys Thr Arg Arg Thr
            2980                2985                2990        
Cys Ser Glu Asn Glu Phe Thr Cys Gly Tyr Gly Leu Cys Ile Pro Lys
        2995                3000                3005            
Ile Phe Arg Cys Asp Arg His Asn Asp Cys Gly Asp Tyr Ser Asp Glu
    3010                3015                3020                
Arg Gly Cys Leu Tyr Gln Thr Cys Gln Gln Asn Gln Phe Thr Cys Gln
3025                3030                3035                3040
Asn Gly Arg Cys Ile Ser Lys Thr Phe Val Cys Asp Glu Asp Asn Asp
                3045                3050                3055    
Cys Gly Asp Gly Ser Asp Glu Leu Met His Leu Cys His Thr Pro Glu
            3060                3065                3070        
Pro Thr Cys Pro Pro His Glu Phe Lys Cys Asp Asn Gly Arg Cys Ile
        3075                3080                3085            
Glu Met Met Lys Leu Cys Asn His Leu Asp Asp Cys Leu Asp Asn Ser
    3090                3095                3100                
Asp Glu Lys Gly Cys Gly Ile Asn Glu Cys His Asp Pro Ser Ile Ser
3105                3110                3115                3120
Gly Cys Asp His Asn Cys Thr Asp Thr Leu Thr Ser Phe Tyr Cys Ser
                3125                3130                3135    
Cys Arg Pro Gly Tyr Lys Leu Met Ser Asp Lys Arg Thr Cys Val Asp
            3140                3145                3150        
Ile Asp Glu Cys Thr Glu Met Pro Phe Val Cys Ser Gln Lys Cys Glu
        3155                3160                3165            
Asn Val Ile Gly Ser Tyr Ile Cys Lys Cys Ala Pro Gly Tyr Leu Arg
    3170                3175                3180                
Glu Pro Asp Gly Lys Thr Cys Arg Gln Asn Ser Asn Ile Glu Pro Tyr
3185                3190                3195                3200
Leu Ile Phe Ser Asn Arg Tyr Tyr Leu Arg Asn Leu Thr Ile Asp Gly
                3205                3210                3215    
Tyr Phe Tyr Ser Leu Ile Leu Glu Gly Leu Asp Asn Val Val Ala Leu
            3220                3225                3230        
Asp Phe Asp Arg Val Glu Lys Arg Leu Tyr Trp Ile Asp Thr Gln Arg
        3235                3240                3245            
Gln Val Ile Glu Arg Met Phe Leu Asn Lys Thr Asn Lys Glu Thr Ile
    3250                3255                3260                
Ile Asn His Arg Leu Pro Ala Ala Glu Ser Leu Ala Val Asp Trp Val
3265                3270                3275                3280
Ser Arg Lys Leu Tyr Trp Leu Asp Ala Arg Leu Asp Gly Leu Phe Val
                3285                3290                3295    
Ser Asp Leu Asn Gly Gly His Arg Arg Met Leu Ala Gln His Cys Val
            3300                3305                3310        
Asp Ala Asn Asn Thr Phe Cys Phe Asp Asn Pro Arg Gly Leu Ala Leu
        3315                3320                3325            
His Pro Gln Tyr Gly Tyr Leu Tyr Trp Ala Asp Trp Gly His Arg Ala
    3330                3335                3340                
Tyr Ile Gly Arg Val Gly Met Asp Gly Thr Asn Lys Ser Val Ile Ile
3345                3350                3355                3360
Ser Thr Lys Leu Glu Trp Pro Asn Gly Ile Thr Ile Asp Tyr Thr Asn
                3365                3370                3375    
Asp Leu Leu Tyr Trp Ala Asp Ala His Leu Gly Tyr Ile Glu Tyr Ser
            3380                3385                3390        
Asp Leu Glu Gly His His Arg His Thr Val Tyr Asp Gly Ala Leu Pro
        3395                3400                3405            
His Pro Phe Ala Ile Thr Ile Phe Glu Asp Thr Ile Tyr Trp Thr Asp
    3410                3415                3420                
Trp Asn Thr Arg Thr Val Glu Lys Gly Asn Lys Tyr Asp Gly Ser Asn
3425                3430                3435                3440
Arg Gln Thr Leu Val Asn Thr Thr His Arg Pro Phe Asp Ile His Val
                3445                3450                3455    
Tyr His Pro Tyr Arg Gln Pro Ile Val Ser Asn Pro Cys Gly Thr Asn
            3460                3465                3470        
Asn Gly Gly Cys Ser His Leu Cys Leu Ile Lys Pro Gly Gly Lys Gly
        3475                3480                3485            
Phe Thr Cys Glu Cys Pro Asp Asp Phe Arg Thr Leu Gln Leu Ser Gly
    3490                3495                3500                
Ser Thr Tyr Cys Met Pro Met Cys Ser Ser Thr Gln Phe Leu Cys Ala
3505                3510                3515                3520
Asn Asn Glu Lys Cys Ile Pro Ile Trp Trp Lys Cys Asp Gly Gln Lys
                3525                3530                3535    
Asp Cys Ser Asp Gly Ser Asp Glu Leu Ala Leu Cys Pro Gln Arg Phe
            3540                3545                3550        
Cys Arg Leu Gly Gln Phe Gln Cys Ser Asp Gly Asn Cys Thr Ser Pro
        3555                3560                3565            
Gln Thr Leu Cys Asn Ala His Gln Asn Cys Pro Asp Gly Ser Asp Glu
    3570                3575                3580                
Asp Arg Leu Leu Cys Glu Asn His His Cys Asp Ser Asn Glu Trp Gln
3585                3590                3595                3600
Cys Ala Asn Lys Arg Cys Ile Pro Glu Ser Trp Gln Cys Asp Thr Phe
                3605                3610                3615    
Asn Asp Cys Glu Asp Asn Ser Asp Glu Asp Ser Ser His Cys Ala Ser
            3620                3625                3630        
Arg Thr Cys Arg Pro Gly Gln Phe Arg Cys Ala Asn Gly Arg Cys Ile
        3635                3640                3645            
Pro Gln Ala Trp Lys Cys Asp Val Asp Asn Asp Cys Gly Asp His Ser
    3650                3655                3660                
Asp Glu Pro Ile Glu Glu Cys Met Ser Ser Ala His Leu Cys Asp Asn
3665                3670                3675                3680
Phe Thr Glu Phe Ser Cys Lys Thr Asn Tyr Arg Cys Ile Pro Lys Trp
                3685                3690                3695    
Ala Val Cys Asn Gly Val Asp Asp Cys Arg Asp Asn Ser Asp Glu Gln
            3700                3705                3710        
Gly Cys Glu Glu Arg Thr Cys His Pro Val Gly Asp Phe Arg Cys Lys
        3715                3720                3725            
Asn His His Cys Ile Pro Leu Arg Trp Gln Cys Asp Gly Gln Asn Asp
    3730                3735                3740                
Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Ala Pro Arg Glu Cys Thr
3745                3750                3755                3760
Glu Ser Glu Phe Arg Cys Val Asn Gln Gln Cys Ile Pro Ser Arg Trp
                3765                3770                3775    
Ile Cys Asp His Tyr Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp
            3780                3785                3790        
Cys Glu Met Arg Thr Cys His Pro Glu Tyr Phe Gln Cys Thr Ser Gly
        3795                3800                3805            
His Cys Val His Ser Glu Leu Lys Cys Asp Gly Ser Ala Asp Cys Leu
    3810                3815                3820                
Asp Ala Ser Asp Glu Ala Asp Cys Pro Thr Arg Phe Pro Asp Gly Ala
3825                3830                3835                3840
Tyr Cys Gln Ala Thr Met Phe Glu Cys Lys Asn His Val Cys Ile Pro
                3845                3850                3855    
Pro Tyr Trp Lys Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp
            3860                3865                3870        
Glu Glu Leu His Leu Cys Leu Asp Val Pro Cys Asn Ser Pro Asn Arg
        3875                3880                3885            
Phe Arg Cys Asp Asn Asn Arg Cys Ile Tyr Ser His Glu Val Cys Asn
    3890                3895                3900                
Gly Val Asp Asp Cys Gly Asp Gly Thr Asp Glu Thr Glu Glu His Cys
3905                3910                3915                3920
Arg Lys Pro Thr Pro Lys Pro Cys Thr Glu Tyr Glu Tyr Lys Cys Gly
                3925                3930                3935    
Asn Gly His Cys Ile Pro His Asp Asn Val Cys Asp Asp Ala Asp Asp
            3940                3945                3950        
Cys Gly Asp Trp Ser Asp Glu Leu Gly Cys Asn Lys Gly Lys Glu Arg
        3955                3960                3965            
Thr Cys Ala Glu Asn Ile Cys Glu Gln Asn Cys Thr Gln Leu Asn Glu
    3970                3975                3980                
Gly Gly Phe Ile Cys Ser Cys Thr Ala Gly Phe Glu Thr Asn Val Phe
3985                3990                3995                4000
Asp Arg Thr Ser Cys Leu Asp Ile Asn Glu Cys Glu Gln Phe Gly Thr
                4005                4010                4015    
Cys Pro Gln His Cys Arg Asn Thr Lys Gly Ser Tyr Glu Cys Val Cys
            4020                4025                4030        
Ala Asp Gly Phe Thr Ser Met Ser Asp Arg Pro Gly Lys Arg Cys Ala
        4035                4040                4045            
Ala Glu Gly Ser Ser Pro Leu Leu Leu Leu Pro Asp Asn Val Arg Ile
    4050                4055                4060                
Arg Lys Tyr Asn Leu Ser Ser Glu Arg Phe Ser Glu Tyr Leu Gln Asp
4065                4070                4075                4080
Glu Glu Tyr Ile Gln Ala Val Asp Tyr Asp Trp Asp Pro Lys Asp Ile
                4085                4090                4095    
Gly Leu Ser Val Val Tyr Tyr Thr Val Arg Gly Glu Gly Ser Arg Phe
            4100                4105                4110        
Gly Ala Ile Lys Arg Ala Tyr Ile Pro Asn Phe Glu Ser Gly Arg Asn
        4115                4120                4125            
Asn Leu Val Gln Glu Val Asp Leu Lys Leu Lys Tyr Val Met Gln Pro
    4130                4135                4140                
Asp Gly Ile Ala Val Asp Trp Val Gly Arg His Ile Tyr Trp Ser Asp
4145                4150                4155                4160
Val Lys Asn Lys Arg Ile Glu Val Ala Lys Leu Asp Gly Arg Tyr Arg
                4165                4170                4175    
Lys Trp Leu Ile Ser Thr Asp Leu Asp Gln Pro Ala Ala Ile Ala Val
            4180                4185                4190        
Asn Pro Lys Leu Gly Leu Met Phe Trp Thr Asp Trp Gly Lys Glu Pro
        4195                4200                4205            
Lys Ile Glu Ser Ala Trp Met Asn Gly Glu Asp Arg Asn Ile Leu Val
    4210                4215                4220                
Phe Glu Asp Leu Gly Trp Pro Thr Gly Leu Ser Ile Asp Tyr Leu Asn
4225                4230                4235                4240
Asn Asp Arg Ile Tyr Trp Ser Asp Phe Lys Glu Asp Val Ile Glu Thr
                4245                4250                4255    
Ile Lys Tyr Asp Gly Thr Asp Arg Arg Val Ile Ala Lys Glu Ala Met
            4260                4265                4270        
Asn Pro Tyr Ser Leu Asp Ile Phe Glu Asp Gln Leu Tyr Trp Ile Ser
        4275                4280                4285            
Lys Glu Lys Gly Glu Val Trp Lys Gln Asn Lys Phe Gly Gln Gly Lys
    4290                4295                4300                
Lys Glu Lys Thr Leu Val Val Asn Pro Trp Leu Thr Gln Val Arg Ile
4305                4310                4315                4320
Phe His Gln Leu Arg Tyr Asn Lys Ser Val Pro Asn Leu Cys Lys Gln
                4325                4330                4335    
Ile Cys Ser His Leu Cys Leu Leu Arg Pro Gly Gly Tyr Ser Cys Ala
            4340                4345                4350        
Cys Pro Gln Gly Ser Ser Phe Ile Glu Gly Ser Thr Thr Glu Cys Asp
        4355                4360                4365            
Ala Ala Ile Glu Leu Pro Ile Asn Leu Pro Pro Pro Cys Arg Cys Met
    4370                4375                4380                
His Gly Gly Asn Cys Tyr Phe Asp Glu Thr Asp Leu Pro Lys Cys Lys
4385                4390                4395                4400
Cys Pro Ser Gly Tyr Thr Gly Lys Tyr Cys Glu Met Ala Phe Ser Lys
                4405                4410                4415    
Gly Ile Ser Pro Gly Thr Thr Ala Val Ala Val Leu Leu Thr Ile Leu
            4420                4425                4430        
Leu Ile Val Val Ile Gly Ala Leu Ala Ile Ala Gly Phe Phe His Tyr
        4435                4440                4445            
Arg Arg Thr Gly Ser Leu Leu Pro Ala Leu Pro Lys Leu Pro Ser Leu
    4450                4455                4460                
Ser Ser Leu Val Lys Pro Ser Glu Asn Gly Asn Gly Val Thr Phe Arg
4465                4470                4475                4480
Ser Gly Ala Asp Leu Asn Met Asp Ile Gly Val Ser Gly Phe Gly Pro
                4485                4490                4495    
Glu Thr Ala Ile Asp Arg Ser Met Ala Met Ser Glu Asp Phe Val Met
            4500                4505                4510        
Glu Met Gly Lys Gln Pro Ile Ile Phe Glu Asn Pro Met Tyr Ser Ala
        4515                4520                4525            
Arg Asp Ser Ala Val Lys Val Val Gln Pro Ile Gln Val Thr Val Ser
    4530                4535                4540                
Glu Asn Val Asp Asn Lys Asn Tyr Gly Ser Pro Ile Asn Pro Ser Glu
4545                4550                4555                4560
Ile Val Pro Glu Thr Asn Pro Thr Ser Pro Ala Ala Asp Gly Thr Gln
                4565                4570                4575    
Val Thr Lys Trp Asn Leu Phe Lys Arg Lys Ser Lys Gln Thr Thr Asn
            4580                4585                4590        
Phe Glu Asn Pro Ile Tyr Ala Gln Met Glu Asn Glu Gln Lys Glu Ser
        4595                4600                4605            
Val Ala Ala Thr Pro Pro Pro Ser Pro Ser Leu Pro Ala Lys Pro Lys
    4610                4615                4620                
Pro Pro Ser Arg Arg Asp Pro Thr Pro Thr Tyr Ser Ala Thr Glu Asp
4625                4630                4635                4640
Thr Phe Lys Asp Thr Ala Asn Leu Val Lys Glu Asp Ser Glu Val
                4645                4650                4655


<210> 8985
<211> 970
<212> PRT
<213> Homo sapiens

<400> 8985
Cys Phe Phe Leu Cys Leu Leu Arg Phe Cys Phe Ser Ala Thr Arg Arg
 1               5                  10                  15      
Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met Gln Ser Asp
            20                  25                  30          
Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys
        35                  40                  45              
Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val
    50                  55                  60                  
Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp
65                  70                  75                  80  
Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val
                85                  90                  95      
Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala
            100                 105                 110         
Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp
        115                 120                 125             
Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly
    130                 135                 140                 
Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala
145                 150                 155                 160 
Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu
                165                 170                 175     
Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg
            180                 185                 190         
Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp
        195                 200                 205             
Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn
    210                 215                 220                 
Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys
225                 230                 235                 240 
Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His
                245                 250                 255     
Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln
            260                 265                 270         
Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu
        275                 280                 285             
Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His
    290                 295                 300                 
Gln His Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala
305                 310                 315                 320 
Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp
                325                 330                 335     
Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile
            340                 345                 350         
Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr
        355                 360                 365             
Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro
    370                 375                 380                 
Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn
385                 390                 395                 400 
Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val
                405                 410                 415     
Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Glu Ile Phe Lys Tyr
            420                 425                 430         
Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg
        435                 440                 445             
Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu
    450                 455                 460                 
Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val
465                 470                 475                 480 
Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu
                485                 490                 495     
Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile
            500                 505                 510         
Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu
        515                 520                 525             
Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp
    530                 535                 540                 
Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile
545                 550                 555                 560 
Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly
                565                 570                 575     
Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe
            580                 585                 590         
Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Asp Gln
        595                 600                 605             
Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu
    610                 615                 620                 
Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe
625                 630                 635                 640 
Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp
                645                 650                 655     
Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln
            660                 665                 670         
Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr
        675                 680                 685             
Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His
    690                 695                 700                 
Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile
705                 710                 715                 720 
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser
                725                 730                 735     
Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg
            740                 745                 750         
Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val
        755                 760                 765             
Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp
    770                 775                 780                 
Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu
785                 790                 795                 800 
Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His
                805                 810                 815     
Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe
            820                 825                 830         
Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys
        835                 840                 845             
Arg Ala Pro Ser Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn
    850                 855                 860                 
Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly
865                 870                 875                 880 
Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met
                885                 890                 895     
Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe
            900                 905                 910         
Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr
        915                 920                 925             
Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile
    930                 935                 940                 
Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser
945                 950                 955                 960 
Thr Leu Phe Leu Val Tyr Ser Asn Ser Glu
                965                 970 


<210> 8986
<211> 979
<212> PRT
<213> Homo sapiens

<400> 8986
Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met Gln
 1               5                  10                  15      
Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val
            20                  25                  30          
Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu
        35                  40                  45              
Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro
    50                  55                  60                  
Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp
65                  70                  75                  80  
Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu
                85                  90                  95      
His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr
            100                 105                 110         
Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro
        115                 120                 125             
Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro
    130                 135                 140                 
Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val
145                 150                 155                 160 
Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val
                165                 170                 175     
Cys Arg Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met
            180                 185                 190         
Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr
        195                 200                 205             
Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His
    210                 215                 220                 
Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu
225                 230                 235                 240 
Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His
                245                 250                 255     
Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln
            260                 265                 270         
Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser
        275                 280                 285             
Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Phe
    290                 295                 300                 
Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu
305                 310                 315                 320 
Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser
                325                 330                 335     
Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys
            340                 345                 350         
Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr
        355                 360                 365             
Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr
    370                 375                 380                 
Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser
385                 390                 395                 400 
Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu
                405                 410                 415     
Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro
            420                 425                 430         
Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu
        435                 440                 445             
Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser
    450                 455                 460                 
Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro
465                 470                 475                 480 
Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile
                485                 490                 495     
Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn
            500                 505                 510         
Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro
        515                 520                 525             
Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met
    530                 535                 540                 
His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys
545                 550                 555                 560 
Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr
                565                 570                 575     
Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met
            580                 585                 590         
Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val
        595                 600                 605             
Phe Met Ser Met Glu Asn Pro Asp Gln Glu Glu Ile Asp Tyr Asp Asp
    610                 615                 620                 
Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu
625                 630                 635                 640 
Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr
                645                 650                 655     
Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser
            660                 665                 670         
Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe
        675                 680                 685             
Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro
    690                 695                 700                 
Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr
705                 710                 715                 720 
Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln
                725                 730                 735     
Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu
            740                 745                 750         
Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn
        755                 760                 765             
Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr
    770                 775                 780                 
Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp
785                 790                 795                 800 
Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys
                805                 810                 815     
His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln
            820                 825                 830         
Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr
        835                 840                 845             
Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Ser Asn Ile Gln
    850                 855                 860                 
Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn
865                 870                 875                 880 
Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln
                885                 890                 895     
Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His
            900                 905                 910         
Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu
        915                 920                 925             
Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val
    930                 935                 940                 
Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile
945                 950                 955                 960 
Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser
                965                 970                 975     
Asn Ser Glu
            


<210> 8987
<211> 781
<212> PRT
<213> Homo sapiens

<400> 8987
Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly
 1               5                  10                  15      
Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg
            20                  25                  30          
Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp
        35                  40                  45              
Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu
    50                  55                  60                  
Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys
65                  70                  75                  80  
Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu
                85                  90                  95      
Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys
            100                 105                 110         
Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg
        115                 120                 125             
Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn
    130                 135                 140                 
Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro
145                 150                 155                 160 
Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp
                165                 170                 175     
Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val
            180                 185                 190         
Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val
        195                 200                 205             
Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu
    210                 215                 220                 
Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser
225                 230                 235                 240 
Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro
                245                 250                 255     
Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala
            260                 265                 270         
Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu
        275                 280                 285             
Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser
    290                 295                 300                 
Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu
305                 310                 315                 320 
Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe
                325                 330                 335     
Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg
            340                 345                 350         
Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala
        355                 360                 365             
Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro
    370                 375                 380                 
Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp
385                 390                 395                 400 
Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser
                405                 410                 415     
Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His
            420                 425                 430         
Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr
        435                 440                 445             
Val Leu Ala Thr Glu Leu Asp Ser Ser Ala Gln Ala Ser Arg Val Gln
    450                 455                 460                 
Val Ala Ile Gln Thr Leu Asp Glu Asn Asp Asn Ala Pro Gln Leu Ala
465                 470                 475                 480 
Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser Ala Ala Pro Gly Gln Leu
                485                 490                 495     
Ile Gln Val Ile Arg Ala Leu Asp Arg Asp Glu Val Gly Asn Ser Ser
            500                 505                 510         
His Val Ser Phe Gln Gly Pro Leu Gly Pro Asp Ala Asn Phe Thr Val
        515                 520                 525             
Gln Asp Asn Arg Asp Gly Ser Ala Ser Leu Leu Leu Pro Ser Arg Pro
    530                 535                 540                 
Ala Pro Pro Arg His Ala Pro Tyr Leu Val Pro Ile Glu Leu Trp Asp
545                 550                 555                 560 
Trp Gly Gln Pro Ala Leu Ser Ser Thr Ala Thr Val Thr Val Ser Val
                565                 570                 575     
Cys Arg Cys Gln Pro Asp Gly Ser Val Ala Ser Cys Trp Pro Glu Ala
            580                 585                 590         
His Leu Ser Ala Ala Gly Leu Ser Thr Gly Ala Leu Leu Ala Ile Ile
        595                 600                 605             
Thr Cys Val Gly Ala Leu Leu Ala Leu Val Val Leu Phe Val Ala Leu
    610                 615                 620                 
Arg Arg Gln Lys Gln Glu Ala Leu Met Val Leu Glu Glu Glu Asp Val
625                 630                 635                 640 
Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp
                645                 650                 655     
Thr Glu Ala Phe Asp Ile Thr Ala Leu Gln Asn Pro Asp Gly Ala Ala
            660                 665                 670         
Pro Pro Ala Pro Gly Pro Pro Ala Arg Arg Asp Val Leu Pro Arg Ala
        675                 680                 685             
Arg Val Ser Arg Gln Pro Arg Pro Pro Gly Pro Ala Asp Val Ala Gln
    690                 695                 700                 
Leu Leu Ala Leu Arg Leu Arg Glu Ala Asp Glu Asp Pro Gly Val Pro
705                 710                 715                 720 
Pro Tyr Asp Ser Val Gln Val Tyr Gly Tyr Glu Gly Arg Gly Ser Ser
                725                 730                 735     
Cys Gly Ser Leu Ser Ser Leu Gly Ser Gly Ser Glu Ala Gly Gly Ala
            740                 745                 750         
Pro Gly Pro Ala Glu Pro Leu Asp Asp Trp Gly Pro Leu Phe Arg Thr
        755                 760                 765             
Leu Ala Glu Leu Tyr Gly Ala Lys Glu Pro Pro Ala Pro
    770                 775                 780     


<210> 8988
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8988
Met His Leu Leu Lys Val Gly Thr Trp Gly Asn Asn Thr Ala Ser Ser
 1               5                  10                  15      
Trp Leu Met Lys Phe Ser Val Leu Trp Leu Val Ser Gln Asn Cys Cys
            20                  25                  30          
Arg Ala Ser Val Val Trp Met Ala Tyr Met Asn Ile Ser Phe His Val
        35                  40                  45              
Gly Asn His Val Leu Ser Glu Leu Gly Glu Thr Gly Val Phe Gly Arg
    50                  55                  60                  
Ser Ser Thr Leu Lys Arg Val Ala Gly Val Ile Val Pro Pro Glu Gly
65                  70                  75                  80  
Lys Ile Gln Asn Ala Cys Asn Pro Asn Thr Ile Phe Ser Arg Ser Lys
                85                  90                  95      
Tyr Ser Glu Thr Trp Leu Ala Leu Ile Glu Arg Gly Gly Cys Thr Phe
            100                 105                 110         
Thr Gln Lys Ile Lys Val Ala Thr Glu Lys Gly Ala Ser Gly Val Ile
        115                 120                 125             
Ile Tyr Asn Val Pro Gly Thr Gly Asn Gln Val Phe Pro Met Phe His
    130                 135                 140                 
Gln Ala Phe Glu Asp Val Val Val Val Met Ile Gly Asn Leu Lys Gly
145                 150                 155                 160 
Thr Glu Ile Phe His Leu Ile Lys Lys Gly Val Leu Ile Thr Ala Val
                165                 170                 175     
Val Glu Val Gly Arg Lys His Ile Ile Trp Met Asn His Tyr Leu Val
            180                 185                 190         
Ser Phe Val Ile Val Thr Thr Ala Thr Leu Ala Tyr Phe Ile Phe Tyr
        195                 200                 205             
His Ile His Arg Leu Cys Leu Ala Arg Ile Gln Asn Arg Arg Trp Gln
    210                 215                 220                 
Arg Leu Thr Thr Asp Leu Gln Asn Thr Phe Gly Gln Leu Gln Leu Arg
225                 230                 235                 240 
Val Val Lys Glu Gly Asp Glu Glu Ile Asn Pro Asn Gly Asp Ser Cys
                245                 250                 255     
Val Ile Cys Phe Glu Arg Tyr Lys Pro Asn Asp Ile Val Arg Ile Leu
            260                 265                 270         
Thr Cys Lys His Phe Phe His Lys Asn Cys Ile Asp Pro Trp Ile Leu
        275                 280                 285             
Pro His Gly Thr Cys Pro Ile Cys Lys Cys Asp Ile Leu Lys Val Leu
    290                 295                 300                 
Gly Ile Gln Val Val Val Glu Asn Gly Thr Glu Pro Leu Gln Val Leu
305                 310                 315                 320 
Met Ser Asn Glu Leu Pro Glu Thr Leu Ser Pro Ser Glu Glu Glu Thr
                325                 330                 335     
Asn Asn Glu Val Ser Pro Ala Gly Thr Ser Asp Lys Val Ile His Val
            340                 345                 350         
Glu Glu Asn Pro Thr Ser Gln Asn Asn Asp Ile Gln Pro His Ser Val
        355                 360                 365             
Val Glu Asp Val His Pro Ser Pro
    370                 375     


<210> 8989
<211> 376
<212> PRT
<213> Homo sapiens

<400> 8989
Met His Leu Leu Lys Val Gly Thr Trp Arg Asn Asn Thr Ala Ser Ser
 1               5                  10                  15      
Trp Leu Met Lys Phe Ser Val Leu Trp Leu Val Ser Gln Asn Cys Cys
            20                  25                  30          
Arg Ala Ser Val Val Trp Met Ala Tyr Met Asn Ile Ser Phe His Val
        35                  40                  45              
Gly Asn His Val Leu Ser Glu Leu Gly Glu Thr Gly Val Phe Gly Arg
    50                  55                  60                  
Ser Ser Thr Leu Lys Arg Val Ala Gly Val Ile Val Pro Pro Glu Gly
65                  70                  75                  80  
Lys Ile Gln Asn Ala Cys Asn Pro Asn Thr Ile Phe Ser Arg Ser Lys
                85                  90                  95      
Tyr Ser Glu Thr Trp Leu Ala Leu Ile Glu Arg Gly Gly Cys Thr Phe
            100                 105                 110         
Thr Gln Lys Ile Lys Val Ala Thr Glu Lys Gly Ala Ser Gly Val Ile
        115                 120                 125             
Ile Tyr Asn Val Pro Gly Thr Gly Asn Gln Val Phe Pro Met Phe His
    130                 135                 140                 
Gln Ala Phe Glu Asp Val Val Val Val Met Ile Gly Asn Leu Lys Gly
145                 150                 155                 160 
Thr Glu Ile Phe His Leu Ile Lys Lys Gly Val Leu Ile Thr Ala Val
                165                 170                 175     
Val Glu Val Gly Arg Lys His Ile Ile Trp Met Asn His Tyr Leu Val
            180                 185                 190         
Ser Phe Val Ile Val Thr Thr Ala Thr Leu Ala Tyr Phe Ile Phe Tyr
        195                 200                 205             
His Ile His Arg Leu Cys Leu Ala Arg Ile Gln Asn Arg Arg Trp Gln
    210                 215                 220                 
Arg Leu Thr Thr Asp Leu Gln Asn Thr Phe Gly Gln Leu Gln Leu Arg
225                 230                 235                 240 
Val Val Lys Glu Gly Asp Glu Glu Ile Asn Pro Asn Gly Asp Ser Cys
                245                 250                 255     
Val Ile Cys Phe Glu Arg Tyr Lys Pro Asn Asp Ile Val Arg Ile Leu
            260                 265                 270         
Thr Cys Lys His Phe Phe His Lys Asn Cys Ile Asp Pro Trp Ile Leu
        275                 280                 285             
Pro His Gly Thr Cys Pro Ile Cys Lys Cys Asp Ile Leu Lys Val Leu
    290                 295                 300                 
Gly Ile Gln Val Val Val Glu Asn Gly Thr Glu Pro Leu Gln Val Leu
305                 310                 315                 320 
Met Ser Asn Glu Leu Pro Glu Thr Leu Ser Pro Ser Glu Glu Glu Thr
                325                 330                 335     
Asn Asn Glu Val Ser Pro Ala Gly Thr Ser Asp Lys Val Ile His Val
            340                 345                 350         
Glu Glu Asn Pro Thr Ser Gln Asn Asn Asp Ile Gln Pro His Ser Val
        355                 360                 365             
Val Glu Asp Val His Pro Ser Pro
    370                 375     


<210> 8990
<211> 160
<212> PRT
<213> Homo sapiens

<400> 8990
Met Leu Pro Phe Leu Phe Phe Ser Thr Leu Phe Ser Ser Ile Phe Thr
 1               5                  10                  15      
Glu Ala Gln Lys Gln Tyr Trp Val Cys Asn Ser Ser Asp Ala Ser Ile
            20                  25                  30          
Ser Tyr Thr Tyr Cys Asp Lys Met Gln Tyr Pro Ile Ser Ile Asn Val
        35                  40                  45              
Asn Pro Cys Ile Glu Leu Lys Gly Ser Lys Gly Leu Leu His Ile Phe
    50                  55                  60                  
Tyr Ile Pro Arg Arg Asp Leu Lys Gln Leu Tyr Phe Asn Leu Tyr Ile
65                  70                  75                  80  
Thr Val Asn Thr Met Asn Leu Pro Lys Arg Lys Glu Val Ile Cys Arg
                85                  90                  95      
Gly Ser Asp Asp Asp Tyr Ser Phe Cys Arg Ala Leu Lys Gly Glu Thr
            100                 105                 110         
Val Asn Thr Thr Ile Ser Phe Ser Phe Lys Gly Ile Lys Phe Ser Lys
        115                 120                 125             
Gly Lys Tyr Lys Cys Val Val Glu Ala Ile Ser Gly Ser Pro Glu Glu
    130                 135                 140                 
Met Leu Phe Cys Leu Glu Phe Val Ile Leu His Gln Pro Asn Ser Asn
145                 150                 155                 160 


<210> 8991
<211> 788
<212> PRT
<213> Homo sapiens

<400> 8991
Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Val Thr Val Leu Ala
 1               5                  10                  15      
Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr
            20                  25                  30          
Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met
        35                  40                  45              
Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys
    50                  55                  60                  
Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile
65                  70                  75                  80  
Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser
                85                  90                  95      
Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln
            100                 105                 110         
Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile
        115                 120                 125             
Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met
    130                 135                 140                 
Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu
145                 150                 155                 160 
Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg
                165                 170                 175     
Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr
            180                 185                 190         
Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr
        195                 200                 205             
Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp
    210                 215                 220                 
Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg
225                 230                 235                 240 
Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr
                245                 250                 255     
Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu
            260                 265                 270         
Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu
        275                 280                 285             
Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp
    290                 295                 300                 
Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu
305                 310                 315                 320 
Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val
                325                 330                 335     
Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro
            340                 345                 350         
Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln
        355                 360                 365             
Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu
    370                 375                 380                 
Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys
385                 390                 395                 400 
Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys
                405                 410                 415     
Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys
            420                 425                 430         
Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys
        435                 440                 445             
Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln
    450                 455                 460                 
Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr
465                 470                 475                 480 
Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln
                485                 490                 495     
Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys
            500                 505                 510         
Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu
        515                 520                 525             
Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly
    530                 535                 540                 
Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu
545                 550                 555                 560 
Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp
                565                 570                 575     
Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr
            580                 585                 590         
Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu
        595                 600                 605             
Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys
    610                 615                 620                 
Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys
625                 630                 635                 640 
Val Glu Cys Lys Lys Phe Asp Arg Glu Pro Tyr Met Thr Glu Asn Thr
                645                 650                 655     
Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys
            660                 665                 670         
Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp
        675                 680                 685             
Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile
    690                 695                 700                 
Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu
705                 710                 715                 720 
Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala
                725                 730                 735     
Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu
            740                 745                 750         
Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala
        755                 760                 765             
Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr
    770                 775                 780                 
Tyr Arg Gly Thr
785             


<210> 8992
<211> 2550
<212> PRT
<213> Homo sapiens

<400> 8992
Pro Gly Trp Arg Lys Glu Ala Ala Thr Met Val Ala Leu Ser Leu Lys
 1               5                  10                  15      
Ile Ser Ile Gly Asn Val Val Lys Thr Met Gln Phe Glu Pro Ser Thr
            20                  25                  30          
Met Val Tyr Asp Ala Cys Arg Ile Ile Arg Glu Arg Ile Pro Glu Ala
        35                  40                  45              
Pro Ala Gly Pro Pro Ser Asp Phe Gly Leu Phe Leu Ser Asp Asp Asp
    50                  55                  60                  
Pro Lys Lys Gly Ile Trp Leu Glu Ala Gly Lys Ala Leu Asp Tyr Tyr
65                  70                  75                  80  
Met Leu Arg Asn Gly Asp Thr Met Glu Tyr Arg Lys Lys Gln Arg Pro
                85                  90                  95      
Leu Lys Ile Arg Met Leu Asp Gly Thr Val Lys Thr Ile Met Val Asp
            100                 105                 110         
Asp Ser Lys Thr Val Thr Asp Met Leu Met Thr Ile Cys Ala Arg Ile
        115                 120                 125             
Gly Ile Thr Asn His Asp Glu Tyr Ser Leu Val Arg Glu Leu Met Glu
    130                 135                 140                 
Glu Lys Lys Glu Glu Ile Thr Gly Thr Leu Arg Lys Asp Lys Thr Leu
145                 150                 155                 160 
Leu Arg Asp Glu Lys Lys Met Glu Lys Leu Lys Gln Lys Leu His Thr
                165                 170                 175     
Asp Asp Glu Leu Asn Trp Leu Asp His Gly Arg Thr Leu Arg Glu Gln
            180                 185                 190         
Gly Val Glu Glu His Glu Thr Leu Leu Leu Arg Arg Lys Phe Phe Tyr
        195                 200                 205             
Ser Asp Gln Asn Val Asp Ser Arg Asp Pro Val Gln Leu Asn Leu Leu
    210                 215                 220                 
Tyr Val Gln Ala Arg Asp Asp Ile Leu Asn Gly Ser His Pro Val Ser
225                 230                 235                 240 
Phe Asp Lys Ala Cys Glu Phe Ala Gly Phe Gln Cys Gln Ile Gln Phe
                245                 250                 255     
Gly Pro His Asn Glu Gln Lys His Lys Ala Gly Phe Leu Asp Leu Lys
            260                 265                 270         
Asp Phe Leu Pro Lys Glu Tyr Val Lys Gln Lys Gly Glu Arg Lys Ile
        275                 280                 285             
Phe Gln Ala His Lys Asn Cys Gly Gln Met Ser Glu Ile Glu Ala Lys
    290                 295                 300                 
Val Arg Tyr Val Lys Leu Ala Arg Ser Leu Lys Thr Tyr Gly Val Ser
305                 310                 315                 320 
Phe Phe Leu Val Lys Glu Lys Met Lys Gly Lys Asn Lys Leu Val Pro
                325                 330                 335     
Arg Leu Leu Gly Ile Thr Lys Glu Cys Val Met Arg Val Asp Glu Lys
            340                 345                 350         
Thr Lys Glu Val Ile Gln Glu Trp Asn Leu Thr Asn Ile Lys Arg Trp
        355                 360                 365             
Ala Ala Ser Pro Lys Ser Phe Thr Leu Asp Phe Gly Asp Tyr Gln Asp
    370                 375                 380                 
Gly Tyr Tyr Ser Val Gln Thr Thr Glu Gly Glu Gln Ile Ala Gln Leu
385                 390                 395                 400 
Ile Ala Gly Tyr Ile Asp Ile Ile Leu Lys Lys Lys Lys Ser Lys Asp
                405                 410                 415     
His Phe Gly Leu Glu Gly Asp Glu Glu Ser Thr Met Leu Glu Asp Ser
            420                 425                 430         
Val Ser Pro Lys Lys Ser Thr Val Leu Gln Gln Gln Tyr Asn Arg Val
        435                 440                 445             
Gly Lys Val Glu His Gly Ser Val Ala Leu Pro Ala Ile Met Arg Ser
    450                 455                 460                 
Gly Ala Ser Gly Pro Glu Asn Phe Gln Val Gly Ser Met Pro Pro Ala
465                 470                 475                 480 
Gln Gln Gln Ile Thr Ser Gly Gln Met His Arg Gly His Met Pro Pro
                485                 490                 495     
Leu Thr Ser Ala Gln Gln Ala Leu Thr Gly Thr Ile Asn Ser Ser Met
            500                 505                 510         
Gln Ala Val Gln Ala Ala Gln Ala Thr Leu Asp Asp Phe Asp Thr Leu
        515                 520                 525             
Pro Pro Leu Gly Gln Asp Ala Ala Ser Lys Ala Trp Arg Lys Asn Lys
    530                 535                 540                 
Met Asp Glu Ser Lys His Glu Ile His Ser Gln Val Asp Ala Ile Thr
545                 550                 555                 560 
Ala Gly Thr Ala Ser Val Val Asn Leu Thr Ala Gly Asp Pro Ala Glu
                565                 570                 575     
Thr Asp Tyr Thr Ala Val Gly Cys Ala Val Thr Thr Ile Ser Ser Asn
            580                 585                 590         
Leu Thr Glu Met Ser Arg Gly Val Lys Leu Leu Ala Ala Leu Leu Glu
        595                 600                 605             
Asp Glu Gly Gly Ser Gly Arg Pro Leu Leu Gln Ala Ala Lys Gly Leu
    610                 615                 620                 
Ala Gly Ala Val Ser Glu Leu Leu Arg Ser Ala Gln Pro Ala Ser Ala
625                 630                 635                 640 
Glu Pro Arg Gln Asn Leu Leu Gln Ala Ala Gly Asn Val Gly Gln Ala
                645                 650                 655     
Ser Gly Glu Leu Leu Gln Gln Ile Gly Glu Ser Asp Thr Asp Pro His
            660                 665                 670         
Phe Gln Asp Ala Leu Met Gln Leu Ala Lys Ala Val Ala Ser Ala Ala
        675                 680                 685             
Ala Ala Leu Val Leu Lys Ala Lys Ser Val Ala Gln Arg Thr Glu Asp
    690                 695                 700                 
Ser Gly Leu Gln Thr Gln Val Ile Ala Ala Ala Thr Gln Cys Ala Leu
705                 710                 715                 720 
Ser Thr Ser Gln Leu Val Ala Cys Thr Lys Val Val Ala Pro Thr Ile
                725                 730                 735     
Ser Ser Pro Val Cys Gln Glu Gln Leu Val Glu Ala Gly Arg Leu Val
            740                 745                 750         
Ala Lys Ala Val Glu Gly Cys Val Ser Ala Ser Gln Ala Ala Thr Glu
        755                 760                 765             
Asp Gly Gln Leu Leu Arg Gly Val Gly Ala Ala Ala Thr Ala Val Thr
    770                 775                 780                 
Gln Ala Leu Asn Glu Leu Leu Gln His Val Lys Ala His Ala Thr Gly
785                 790                 795                 800 
Ala Gly Pro Ala Gly Arg Tyr Asp Gln Ala Thr Asp Thr Ile Leu Thr
                805                 810                 815     
Val Thr Glu Asn Ile Phe Ser Ser Met Gly Asp Ala Gly Glu Met Val
            820                 825                 830         
Arg Gln Ala Arg Ile Leu Ala Gln Ala Thr Ser Asp Leu Val Asn Ala
        835                 840                 845             
Ile Lys Ala Asp Ala Glu Gly Glu Ser Asp Leu Glu Asn Ser Arg Lys
    850                 855                 860                 
Leu Leu Ser Ala Ala Lys Ile Leu Ala Asp Ala Thr Ala Lys Met Val
865                 870                 875                 880 
Glu Ala Ala Lys Gly Ala Ala Ala His Pro Asp Ser Glu Glu Gln Gln
                885                 890                 895     
Gln Arg Leu Arg Glu Ala Ala Glu Gly Leu Arg Met Ala Thr Asn Ala
            900                 905                 910         
Ala Ala Gln Asn Ala Ile Lys Lys Lys Leu Val Gln Arg Leu Glu His
        915                 920                 925             
Ala Ala Lys Gln Ala Ala Ala Ser Ala Thr Gln Thr Ile Ala Ala Ala
    930                 935                 940                 
Gln His Ala Ala Ser Thr Pro Lys Ala Ser Ala Gly Pro Gln Pro Leu
945                 950                 955                 960 
Leu Val Gln Ser Cys Lys Ala Val Ala Glu Gln Ile Pro Leu Leu Val
                965                 970                 975     
Gln Gly Val Arg Gly Ser Gln Ala Gln Pro Asp Ser Pro Ser Ala Gln
            980                 985                 990         
Leu Ala Leu Ile Ala Ala Ser Gln Ser Phe Leu Gln Pro Gly Gly Lys
        995                 1000                1005            
Met Val Ala Ala Ala Lys Ala Ser Val Pro Thr Ile Gln Asp Gln Ala
    1010                1015                1020                
Ser Ala Met Gln Leu Ser Gln Cys Ala Lys Asn Leu Gly Thr Ala Leu
1025                1030                1035                1040
Ala Glu Leu Arg Thr Ala Ala Gln Lys Ala Gln Glu Ala Cys Gly Pro
                1045                1050                1055    
Leu Glu Met Asp Ser Ala Leu Ser Val Val Gln Asn Leu Glu Lys Asp
            1060                1065                1070        
Leu Gln Glu Val Lys Ala Ala Ala Arg Asp Gly Lys Leu Lys Pro Leu
        1075                1080                1085            
Pro Gly Glu Thr Met Glu Lys Cys Thr Gln Asp Leu Gly Asn Ser Thr
    1090                1095                1100                
Lys Ala Val Ser Ser Ala Ile Ala Gln Leu Leu Gly Glu Val Ala Gln
1105                1110                1115                1120
Gly Asn Glu Asn Tyr Ala Gly Ile Ala Ala Arg Asp Val Ala Gly Gly
                1125                1130                1135    
Leu Arg Ser Leu Ala Gln Ala Ala Arg Gly Val Ala Ala Leu Thr Ser
            1140                1145                1150        
Asp Pro Ala Val Gln Ala Ile Val Leu Asp Thr Ala Ser Asp Val Leu
        1155                1160                1165            
Asp Lys Ala Ser Ser Leu Ile Glu Glu Ala Lys Lys Ala Ala Gly His
    1170                1175                1180                
Pro Gly Asp Pro Glu Ser Gln Gln Arg Leu Ala Gln Val Ala Lys Ala
1185                1190                1195                1200
Val Thr Gln Ala Leu Asn Arg Cys Val Ser Cys Leu Pro Gly Gln Arg
                1205                1210                1215    
Asp Val Asp Asn Ala Leu Arg Ala Val Gly Asp Ala Ser Lys Arg Leu
            1220                1225                1230        
Leu Ser Asp Ser Leu Pro Pro Ser Thr Gly Thr Phe Gln Glu Ala Gln
        1235                1240                1245            
Ser Arg Leu Asn Glu Ala Ala Ala Gly Leu Asn Gln Ala Ala Thr Glu
    1250                1255                1260                
Leu Val Gln Ala Ser Arg Gly Thr Pro Gln Asp Leu Ala Arg Ala Ser
1265                1270                1275                1280
Gly Arg Phe Gly Gln Asp Phe Ser Thr Phe Leu Glu Ala Gly Val Glu
                1285                1290                1295    
Met Ala Gly Gln Ala Pro Ser Gln Glu Asp Arg Ala Gln Val Val Ser
            1300                1305                1310        
Asn Leu Lys Gly Ile Ser Met Ser Ser Ser Lys Leu Leu Leu Ala Ala
        1315                1320                1325            
Lys Ala Leu Ser Thr Asp Pro Ala Ala Pro Asn Leu Lys Ser Gln Leu
    1330                1335                1340                
Ala Ala Ala Ala Arg Ala Val Thr Asp Ser Ile Asn Gln Leu Ile Thr
1345                1350                1355                1360
Met Cys Thr Gln Gln Ala Pro Gly Gln Lys Glu Cys Asp Asn Ala Leu
                1365                1370                1375    
Arg Glu Leu Glu Thr Val Arg Glu Leu Leu Glu Asn Pro Val Gln Pro
            1380                1385                1390        
Ile Asn Asp Met Ser Tyr Phe Gly Cys Leu Asp Ser Val Met Glu Asn
        1395                1400                1405            
Ser Lys Val Leu Gly Glu Ala Met Thr Gly Ile Ser Gln Asn Ala Lys
    1410                1415                1420                
Asn Gly Asn Leu Pro Glu Phe Gly Asp Ala Ile Ser Thr Ala Ser Lys
1425                1430                1435                1440
Ala Leu Cys Gly Phe Thr Glu Ala Ala Ala Gln Ala Ala Tyr Leu Val
                1445                1450                1455    
Gly Val Ser Asp Pro Asn Ser Gln Ala Gly Gln Gln Gly Leu Val Glu
            1460                1465                1470        
Pro Thr Gln Phe Ala Arg Ala Asn Gln Ala Ile Gln Met Ala Cys Gln
        1475                1480                1485            
Ser Leu Gly Glu Pro Gly Cys Thr Gln Ala Gln Val Leu Ser Ala Ala
    1490                1495                1500                
Thr Ile Val Ala Lys His Thr Ser Ala Leu Cys Asn Ser Cys Arg Leu
1505                1510                1515                1520
Ala Ser Ala Arg Thr Thr Asn Pro Thr Ala Lys Arg Gln Phe Val Gln
                1525                1530                1535    
Ser Ala Lys Glu Val Ala Asn Ser Thr Ala Asn Leu Val Lys Thr Ile
            1540                1545                1550        
Lys Ala Leu Asp Gly Ala Phe Thr Glu Glu Asn Arg Ala Gln Cys Arg
        1555                1560                1565            
Ala Ala Thr Ala Pro Leu Leu Glu Ala Val Asp Asn Leu Ser Ala Phe
    1570                1575                1580                
Ala Ser Asn Pro Glu Phe Ser Ser Ile Pro Ala Gln Ile Ser Pro Glu
1585                1590                1595                1600
Gly Arg Ala Ala Met Glu Pro Ile Val Ile Ser Ala Lys Thr Met Leu
                1605                1610                1615    
Glu Ser Ala Gly Gly Leu Ile Gln Thr Ala Arg Ala Leu Ala Val Asn
            1620                1625                1630        
Pro Arg Asp Pro Pro Ser Trp Ser Val Leu Ala Gly His Ser Arg Thr
        1635                1640                1645            
Val Ser Asp Ser Ile Lys Lys Leu Ile Thr Ser Met Arg Asp Lys Ala
    1650                1655                1660                
Pro Gly Gln Leu Glu Cys Glu Thr Ala Ile Ala Ala Leu Asn Ser Cys
1665                1670                1675                1680
Leu Arg Asp Leu Asp Gln Ala Ser Leu Ala Ala Val Ser Gln Gln Leu
                1685                1690                1695    
Ala Pro Arg Glu Gly Ile Ser Gln Glu Ala Leu His Thr Gln Met Leu
            1700                1705                1710        
Thr Ala Val Gln Glu Ile Ser His Leu Ile Glu Pro Leu Ala Asn Ala
        1715                1720                1725            
Ala Arg Ala Glu Ala Ser Gln Leu Gly His Lys Val Ser Gln Met Ala
    1730                1735                1740                
Gln Tyr Phe Glu Pro Leu Thr Leu Ala Ala Val Gly Ala Ala Ser Lys
1745                1750                1755                1760
Thr Leu Ser His Pro Gln Gln Met Ala Leu Leu Asp Gln Thr Lys Thr
                1765                1770                1775    
Leu Ala Glu Ser Ala Leu Gln Leu Leu Tyr Thr Ala Lys Glu Ala Gly
            1780                1785                1790        
Gly Asn Pro Lys Gln Ala Ala His Thr Gln Glu Ala Leu Glu Glu Ala
        1795                1800                1805            
Val Gln Met Met Thr Glu Ala Val Glu Asp Leu Thr Thr Thr Leu Asn
    1810                1815                1820                
Glu Ala Ala Ser Ala Ala Gly Val Val Gly Gly Met Val Asp Ser Ile
1825                1830                1835                1840
Thr Gln Ala Ile Asn Gln Leu Asp Glu Gly Pro Met Gly Glu Pro Glu
                1845                1850                1855    
Gly Ser Phe Val Asp Tyr Gln Thr Thr Met Val Arg Thr Ala Lys Ala
            1860                1865                1870        
Ile Ala Val Thr Val Gln Glu Met Val Thr Lys Ser Asn Thr Ser Pro
        1875                1880                1885            
Glu Glu Leu Gly Pro Leu Ala Asn Gln Leu Thr Ser Asp Tyr Gly Arg
    1890                1895                1900                
Leu Ala Ser Glu Ala Lys Pro Ala Ala Val Ala Ala Glu Asn Glu Glu
1905                1910                1915                1920
Ile Gly Ser His Ile Lys His Arg Val Gln Glu Leu Gly His Gly Cys
                1925                1930                1935    
Ala Ala Leu Val Thr Lys Ala Gly Ala Leu Gln Cys Ser Pro Ser Asp
            1940                1945                1950        
Ala Tyr Thr Lys Lys Glu Leu Ile Glu Cys Ala Arg Arg Val Ser Glu
        1955                1960                1965            
Lys Val Ser His Val Leu Ala Ala Leu Gln Ala Gly Asn Arg Gly Thr
    1970                1975                1980                
Gln Ala Cys Ile Thr Ala Ala Ser Ala Val Ser Gly Ile Ile Ala Asp
1985                1990                1995                2000
Leu Asp Thr Thr Ile Met Phe Ala Thr Ala Gly Thr Leu Asn Arg Glu
                2005                2010                2015    
Gly Thr Glu Thr Phe Ala Asp His Arg Glu Gly Ile Leu Lys Thr Ala
            2020                2025                2030        
Lys Val Leu Val Glu Asp Thr Lys Val Leu Val Gln Asn Ala Ala Gly
        2035                2040                2045            
Ser Gln Glu Lys Leu Ala Gln Ala Ala Gln Ser Ser Val Ala Thr Ile
    2050                2055                2060                
Thr Arg Leu Ala Asp Val Val Lys Leu Gly Ala Ala Ser Leu Gly Ala
2065                2070                2075                2080
Glu Asp Pro Glu Thr Gln Val Val Leu Ile Asn Ala Val Lys Asp Val
                2085                2090                2095    
Ala Lys Ala Leu Gly Asp Leu Ile Ser Ala Thr Lys Ala Ala Ala Gly
            2100                2105                2110        
Lys Val Gly Asp Asp Pro Ala Val Trp Gln Leu Lys Asn Ser Ala Lys
        2115                2120                2125            
Val Met Val Thr Asn Val Thr Ser Leu Leu Lys Thr Val Lys Ala Val
    2130                2135                2140                
Glu Asp Glu Ala Thr Lys Gly Thr Arg Ala Leu Glu Ala Thr Thr Glu
2145                2150                2155                2160
His Ile Arg Gln Glu Leu Ala Val Phe Cys Ser Pro Glu Pro Pro Ala
                2165                2170                2175    
Lys Thr Ser Thr Pro Glu Asp Phe Ile Arg Met Thr Lys Gly Ile Thr
            2180                2185                2190        
Met Ala Thr Ala Lys Ala Val Ala Ala Gly Asn Ser Cys Arg Gln Glu
        2195                2200                2205            
Asp Val Ile Ala Thr Ala Asn Leu Ser Arg Arg Ala Ile Ala Asp Met
    2210                2215                2220                
Leu Arg Ala Cys Lys Glu Ala Ala Tyr His Pro Glu Val Ala Pro Asp
2225                2230                2235                2240
Val Arg Leu Arg Ala Leu His Tyr Gly Arg Glu Cys Ala Asn Gly Tyr
                2245                2250                2255    
Leu Glu Leu Leu Asp His Val Leu Leu Thr Leu Gln Lys Pro Ser Pro
            2260                2265                2270        
Glu Leu Lys Gln Gln Leu Thr Gly His Ser Lys Arg Val Ala Gly Ser
        2275                2280                2285            
Val Thr Glu Leu Ile Gln Ala Ala Glu Ala Met Lys Gly Thr Glu Trp
    2290                2295                2300                
Val Asp Pro Glu Asp Pro Thr Val Ile Ala Glu Asn Glu Leu Leu Gly
2305                2310                2315                2320
Ala Ala Ala Ala Ile Glu Ala Ala Ala Lys Lys Leu Glu Gln Leu Lys
                2325                2330                2335    
Pro Arg Ala Lys Pro Lys Glu Ala Asp Glu Ser Leu Asn Phe Glu Glu
            2340                2345                2350        
Gln Ile Leu Glu Ala Ala Lys Ser Ile Ala Ala Ala Thr Ser Ala Leu
        2355                2360                2365            
Val Lys Ala Ala Ser Ala Ala Gln Arg Glu Leu Val Ala Gln Gly Lys
    2370                2375                2380                
Val Gly Ala Ile Pro Ala Asn Ala Leu Asp Asp Gly Gln Trp Ser Gln
2385                2390                2395                2400
Gly Leu Ile Ser Ala Ala Arg Met Val Ala Ala Ala Thr Asn Asn Leu
                2405                2410                2415    
Cys Glu Ala Ala Asn Ala Ala Val Gln Gly His Ala Ser Gln Glu Lys
            2420                2425                2430        
Leu Ile Ser Ser Ala Lys Gln Val Ala Ala Ser Thr Ala Gln Leu Leu
        2435                2440                2445            
Val Ala Cys Lys Val Lys Ala Asp Gln Asp Ser Glu Ala Met Lys Arg
    2450                2455                2460                
Leu Gln Ala Ala Gly Asn Ala Val Lys Arg Ala Ser Asp Asn Leu Val
2465                2470                2475                2480
Lys Ala Ala Gln Lys Ala Ala Ala Phe Glu Glu Gln Glu Asn Glu Thr
                2485                2490                2495    
Val Val Val Lys Glu Lys Met Val Gly Gly Ile Ala Gln Ile Ile Ala
            2500                2505                2510        
Ala Gln Glu Glu Met Leu Arg Lys Glu Arg Glu Leu Glu Glu Ala Arg
        2515                2520                2525            
Lys Lys Leu Ala Gln Ile Arg Gln Gln Gln Tyr Lys Phe Leu Pro Ser
    2530                2535                2540                
Glu Leu Arg Asp Glu His
2545                2550


<210> 8993
<211> 1307
<212> PRT
<213> Homo sapiens

<400> 8993
Met Asp Ser Leu Pro Arg Leu Thr Ser Val Leu Thr Leu Leu Phe Ser
 1               5                  10                  15      
Gly Leu Trp His Leu Gly Leu Thr Ala Thr Asn Tyr Asn Cys Asp Asp
            20                  25                  30          
Pro Leu Ala Ser Leu Leu Ser Pro Met Ala Phe Ser Ser Ser Ser Asp
        35                  40                  45              
Leu Thr Gly Thr His Ser Pro Ala Gln Leu Asn Trp Arg Val Gly Thr
    50                  55                  60                  
Gly Gly Trp Ser Pro Ala Asp Ser Asn Ala Gln Gln Trp Leu Gln Met
65                  70                  75                  80  
Asp Leu Gly Asn Arg Val Glu Ile Thr Ala Val Ala Thr Gln Gly Arg
                85                  90                  95      
Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Ser Leu Met Phe Ser Asp
            100                 105                 110         
Thr Gly Arg Asn Trp Lys Gln Tyr Lys Gln Glu Asp Ser Ile Trp Thr
        115                 120                 125             
Phe Ala Gly Asn Met Asn Ala Asp Ser Val Val His His Lys Leu Leu
    130                 135                 140                 
His Ser Val Arg Ala Arg Phe Val Arg Phe Val Pro Leu Glu Trp Asn
145                 150                 155                 160 
Pro Ser Gly Lys Ile Gly Met Arg Val Glu Val Tyr Gly Cys Ser Tyr
                165                 170                 175     
Lys Ser Asp Val Ala Asp Phe Asp Gly Arg Ser Ser Leu Leu Tyr Arg
            180                 185                 190         
Phe Asn Gln Lys Leu Met Ser Thr Leu Lys Asp Val Ile Ser Leu Lys
        195                 200                 205             
Phe Lys Ser Met Gln Gly Asp Gly Val Leu Phe His Gly Glu Gly Gln
    210                 215                 220                 
Arg Gly Asp His Ile Thr Leu Glu Leu Gln Lys Gly Arg Leu Ala Leu
225                 230                 235                 240 
His Leu Asn Leu Gly Asp Ser Lys Ala Arg Leu Ser Ser Ser Leu Pro
                245                 250                 255     
Ser Ala Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp His Ser Val
            260                 265                 270         
Leu Ile Glu Arg Val Gly Lys Gln Val Asn Phe Thr Val Asp Lys His
        275                 280                 285             
Thr Gln His Phe Arg Thr Lys Gly Glu Thr Asp Ala Leu Asp Ile Asp
    290                 295                 300                 
Tyr Glu Leu Ser Phe Gly Gly Ile Pro Val Pro Gly Lys Pro Gly Thr
305                 310                 315                 320 
Phe Leu Lys Lys Asn Phe His Gly Cys Ile Glu Asn Leu Tyr Tyr Asn
                325                 330                 335     
Gly Val Asn Ile Ile Asp Leu Ala Lys Arg Arg Lys His Gln Ile Tyr
            340                 345                 350         
Thr Val Gly Asn Val Thr Phe Ser Cys Ser Glu Pro Gln Ile Val Pro
        355                 360                 365             
Ile Thr Phe Val Asn Ser Ser Gly Ser Tyr Leu Leu Leu Pro Gly Thr
    370                 375                 380                 
Pro Gln Ile Asp Gly Leu Ser Val Ser Phe Gln Phe Arg Thr Trp Asn
385                 390                 395                 400 
Lys Asp Gly Leu Leu Leu Ser Thr Glu Leu Ser Glu Gly Ser Gly Thr
                405                 410                 415     
Leu Leu Leu Ser Leu Glu Gly Gly Ile Leu Arg Leu Val Ile Gln Lys
            420                 425                 430         
Met Thr Glu Arg Val Ala Glu Ile Leu Thr Gly Ser Asn Leu Asn Asp
        435                 440                 445             
Gly Leu Trp His Ser Val Ser Ile Asn Ala Arg Arg Asn Arg Ile Thr
    450                 455                 460                 
Leu Thr Leu Asp Asp Glu Ala Ala Pro Pro Ala Pro Asp Ser Thr Trp
465                 470                 475                 480 
Val Gln Ile Tyr Ser Gly Asn Ser Tyr Tyr Phe Gly Gly Cys Pro Asp
                485                 490                 495     
Asn Leu Thr Asp Ser Gln Cys Leu Asn Pro Ile Lys Ala Phe Gln Gly
            500                 505                 510         
Cys Met Arg Leu Ile Phe Ile Asp Asn Gln Pro Lys Asp Leu Ile Ser
        515                 520                 525             
Val Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu His Ile Asp Leu
    530                 535                 540                 
Cys Ser Ile Lys Asp Arg Cys Leu Pro Asn Tyr Cys Glu His Gly Gly
545                 550                 555                 560 
Ser Cys Ser Gln Ser Trp Thr Thr Phe Tyr Cys Asn Cys Ser Asp Thr
                565                 570                 575     
Ser Tyr Thr Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln Ser Cys
            580                 585                 590         
Glu Val Tyr Arg His Gln Gly Asn Thr Ala Gly Phe Phe Tyr Ile Asp
        595                 600                 605             
Ser Asp Gly Ser Gly Pro Leu Gly Pro Leu Gln Val Tyr Cys Asn Ile
    610                 615                 620                 
Thr Glu Asp Lys Ile Trp Thr Ser Val Gln His Asn Asn Thr Glu Leu
625                 630                 635                 640 
Thr Arg Val Arg Gly Ala Asn Pro Glu Lys Pro Tyr Ala Met Ala Leu
                645                 650                 655     
Asp Tyr Gly Gly Ser Met Glu Gln Leu Glu Ala Val Ile Asp Gly Ser
            660                 665                 670         
Glu His Cys Glu Gln Glu Val Ala Tyr His Cys Arg Arg Ser Arg Leu
        675                 680                 685             
Leu Asn Thr Pro Asp Gly Thr Pro Phe Thr Trp Trp Ile Gly Arg Ser
    690                 695                 700                 
Asn Glu Arg His Pro Tyr Trp Gly Gly Ser Pro Pro Gly Val Gln Gln
705                 710                 715                 720 
Cys Glu Cys Gly Leu Asp Glu Ser Cys Leu Asp Ile Gln His Phe Cys
                725                 730                 735     
Asn Cys Asp Ala Asp Lys Asp Glu Trp Thr Asn Asp Thr Gly Phe Leu
            740                 745                 750         
Ser Phe Lys Asp His Leu Pro Val Thr Gln Ile Val Ile Thr Asp Thr
        755                 760                 765             
Asp Arg Ser Asn Ser Glu Ala Ala Trp Arg Ile Gly Pro Leu Arg Cys
    770                 775                 780                 
Tyr Gly Asp Arg Arg Phe Trp Asn Ala Val Ser Phe Tyr Thr Glu Ala
785                 790                 795                 800 
Ser Tyr Leu His Phe Pro Thr Phe His Ala Glu Phe Ser Ala Asp Ile
                805                 810                 815     
Ser Phe Phe Phe Lys Thr Thr Ala Leu Ser Gly Val Phe Leu Glu Asn
            820                 825                 830         
Leu Gly Ile Lys Asp Phe Ile Arg Leu Glu Ile Ser Ser Pro Ser Glu
        835                 840                 845             
Ile Thr Phe Ala Ile Asp Val Gly Asn Gly Pro Val Glu Leu Val Val
    850                 855                 860                 
Gln Ser Pro Ser Leu Leu Asn Asp Asn Gln Trp His Tyr Val Arg Ala
865                 870                 875                 880 
Glu Arg Asn Leu Lys Glu Thr Ser Leu Gln Val Asp Asn Leu Pro Arg
                885                 890                 895     
Ser Thr Arg Glu Thr Ser Glu Glu Gly His Phe Arg Leu Gln Leu Asn
            900                 905                 910         
Ser Gln Leu Phe Val Gly Gly Thr Ser Ser Arg Gln Lys Gly Phe Leu
        915                 920                 925             
Gly Cys Ile Arg Ser Leu His Leu Asn Gly Gln Lys Met Asp Leu Glu
    930                 935                 940                 
Glu Arg Ala Lys Val Thr Ser Gly Val Arg Pro Gly Cys Pro Gly His
945                 950                 955                 960 
Cys Ser Ser Tyr Gly Ser Ile Cys His Asn Gly Gly Lys Cys Val Glu
                965                 970                 975     
Lys His Asn Gly Tyr Leu Cys Asp Cys Thr Asn Ser Pro Tyr Glu Gly
            980                 985                 990         
Pro Phe Cys Lys Lys Glu Val Ser Ala Val Phe Glu Ala Gly Thr Ser
        995                 1000                1005            
Val Thr Tyr Met Phe Gln Glu Pro Tyr Pro Val Thr Lys Asn Ile Ser
    1010                1015                1020                
Leu Ser Ser Ser Ala Ile Tyr Thr Asp Ser Ala Pro Ser Lys Glu Asn
1025                1030                1035                1040
Ile Ala Leu Ser Phe Val Thr Thr Gln Ala Pro Ser Leu Leu Leu Phe
                1045                1050                1055    
Ile Asn Ser Ser Ser Gln Asp Phe Val Val Val Leu Leu Cys Lys Asn
            1060                1065                1070        
Gly Ser Leu Gln Val Arg Tyr His Leu Asn Lys Glu Glu Thr His Val
        1075                1080                1085            
Phe Thr Ile Asp Ala Asp Asn Phe Ala Asn Arg Arg Met His His Leu
    1090                1095                1100                
Lys Ile Asn Arg Glu Gly Arg Glu Leu Thr Ile Gln Met Asp Gln Gln
1105                1110                1115                1120
Leu Arg Leu Ser Tyr Asn Phe Ser Pro Glu Val Glu Phe Arg Val Ile
                1125                1130                1135    
Arg Ser Leu Thr Leu Gly Lys Val Thr Glu Asn Leu Gly Leu Asp Ser
            1140                1145                1150        
Glu Val Ala Lys Ala Asn Ala Met Gly Phe Ala Gly Cys Met Ser Ser
        1155                1160                1165            
Val Gln Tyr Asn His Ile Ala Pro Leu Lys Ala Ala Leu Arg His Ala
    1170                1175                1180                
Thr Val Ala Pro Val Thr Val His Gly Thr Leu Thr Glu Ser Ser Cys
1185                1190                1195                1200
Gly Phe Met Val Asp Ser Asp Val Asn Ala Val Thr Thr Val His Ser
                1205                1210                1215    
Ser Ser Asp Pro Phe Gly Lys Thr Asp Glu Arg Glu Pro Leu Thr Asn
            1220                1225                1230        
Ala Val Arg Ser Asp Ser Ala Val Ile Gly Gly Val Ile Ala Val Val
        1235                1240                1245            
Ile Phe Ile Ile Phe Cys Ile Ile Gly Ile Met Thr Arg Phe Leu Tyr
    1250                1255                1260                
Gln His Lys Gln Ser His Arg Thr Ser Gln Met Lys Glu Lys Glu Tyr
1265                1270                1275                1280
Pro Glu Asn Leu Asp Ser Ser Phe Arg Asn Glu Ile Asp Leu Gln Asn
                1285                1290                1295    
Thr Val Ser Glu Cys Lys Arg Glu Tyr Phe Ile
            1300                1305        


<210> 8994
<211> 506
<212> PRT
<213> Homo sapiens

<400> 8994
Tyr Asn Leu Ser Ser His Ala Phe Phe Leu Pro Leu Leu Pro Lys Ser
 1               5                  10                  15      
Ser Thr Ile Glu Glu Glu Glu Asn Met Ser Gly His Lys Cys Tyr Pro
            20                  25                  30          
Trp Asp Leu Gln Asp Arg Tyr Ala Gln Asp Lys Ser Val Val Asn Lys
        35                  40                  45              
Met Gln Gln Lys Tyr Trp Glu Thr Lys Gln Ala Phe Ile Lys Ala Thr
    50                  55                  60                  
Gly Lys Lys Glu Asp Glu His Val Val Ala Ser Asp Ala Asp Leu Asp
65                  70                  75                  80  
Ala Lys Leu Glu Leu Phe His Ser Ile Gln Arg Thr Cys Leu Asp Leu
                85                  90                  95      
Ser Lys Ala Ile Val Leu Tyr Gln Lys Arg Ile Cys Phe Leu Ser Gln
            100                 105                 110         
Glu Glu Asn Glu Leu Gly Lys Phe Leu Arg Ser Gln Gly Phe Gln Asp
        115                 120                 125             
Lys Thr Arg Ala Gly Lys Met Met Gln Ala Thr Gly Lys Ala Leu Cys
    130                 135                 140                 
Phe Ser Ser Gln Gln Arg Leu Ala Leu Arg Asn Pro Leu Cys Arg Phe
145                 150                 155                 160 
His Gln Glu Val Glu Thr Phe Arg His Arg Ala Ile Ser Asp Thr Trp
                165                 170                 175     
Leu Thr Val Asn Arg Met Glu Gln Cys Arg Thr Glu Tyr Arg Gly Ala
            180                 185                 190         
Leu Leu Trp Met Lys Asp Val Ser Gln Glu Leu Asp Pro Asp Leu Tyr
        195                 200                 205             
Lys Gln Met Glu Lys Phe Arg Lys Val Gln Thr Gln Val Arg Leu Ala
    210                 215                 220                 
Lys Lys Asn Phe Asp Lys Leu Lys Met Asp Val Cys Gln Lys Val Asp
225                 230                 235                 240 
Leu Leu Gly Ala Ser Arg Cys Asn Leu Leu Ser His Met Leu Ala Thr
                245                 250                 255     
Tyr Gln Thr Thr Leu Leu His Phe Trp Glu Lys Thr Ser His Thr Met
            260                 265                 270         
Ala Ala Ile His Glu Ser Phe Lys Gly Tyr Gln Pro Tyr Glu Phe Thr
        275                 280                 285             
Thr Leu Lys Ser Leu Gln Asp Pro Met Lys Lys Leu Val Glu Lys Glu
    290                 295                 300                 
Glu Lys Lys Lys Ile Asn Gln Gln Glu Ser Thr Asp Ala Ala Val Gln
305                 310                 315                 320 
Glu Pro Ser Gln Leu Ile Ser Leu Glu Glu Glu Asn Gln Arg Lys Glu
                325                 330                 335     
Ser Ser Ser Phe Lys Thr Glu Asp Gly Lys Ser Ile Leu Ser Ala Leu
            340                 345                 350         
Asp Lys Gly Ser Thr His Thr Ala Cys Ser Gly Pro Ile Asp Glu Leu
        355                 360                 365             
Leu Asp Met Lys Ser Glu Glu Gly Ala Cys Leu Gly Pro Val Ala Gly
    370                 375                 380                 
Thr Pro Glu Pro Glu Gly Ala Asp Lys Asp Asp Leu Leu Leu Leu Ser
385                 390                 395                 400 
Glu Ile Phe Asn Ala Ser Ser Leu Glu Glu Gly Glu Phe Ser Lys Glu
                405                 410                 415     
Trp Ala Ala Val Phe Gly Asp Gly Gln Val Lys Glu Pro Val Pro Thr
            420                 425                 430         
Met Ala Leu Gly Glu Pro Asp Pro Lys Ala Gln Thr Gly Ser Gly Phe
        435                 440                 445             
Leu Pro Ser Gln Leu Leu Asp Gln Asn Met Lys Asp Leu Gln Ala Ser
    450                 455                 460                 
Leu Gln Glu Pro Ala Lys Ala Ala Ser Asp Leu Thr Ala Trp Phe Ser
465                 470                 475                 480 
Leu Phe Ala Asp Leu Asp Pro Leu Ser Asn Pro Asp Ala Val Gly Lys
                485                 490                 495     
Thr Asp Lys Glu His Glu Leu Leu Asn Ala
            500                 505     


<210> 8995
<211> 462
<212> PRT
<213> Homo sapiens

<400> 8995
Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro
 1               5                  10                  15      
Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly
            20                  25                  30          
Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln
        35                  40                  45              
Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp
    50                  55                  60                  
Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg
65                  70                  75                  80  
Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val
                85                  90                  95      
Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg
            100                 105                 110         
Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe
        115                 120                 125             
Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser
    130                 135                 140                 
Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly
145                 150                 155                 160 
Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser
                165                 170                 175     
Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp
            180                 185                 190         
Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg
        195                 200                 205             
Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr
    210                 215                 220                 
Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly
225                 230                 235                 240 
Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu
                245                 250                 255     
Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu
            260                 265                 270         
Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly
        275                 280                 285             
Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu
    290                 295                 300                 
Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala
305                 310                 315                 320 
Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro
                325                 330                 335     
Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val
            340                 345                 350         
Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Ala Arg
        355                 360                 365             
Val Phe Ser Thr Val Thr Ala Val Ser Val Leu Leu Leu Leu Leu Leu
    370                 375                 380                 
Gly Leu Leu Arg Pro Leu Arg Arg Arg Ser Cys Leu Leu Ala Pro Gly
385                 390                 395                 400 
Lys Gly Pro Pro Ala Leu Gly Ala Ser Arg Gly Pro Arg Arg Ser Trp
                405                 410                 415     
Ala Val Trp Tyr Gln Gln Pro Arg Gly Val Ala Leu Pro Cys Ser Pro
            420                 425                 430         
Gly Asp Pro Gln Ala Glu Gly Ser Ala Ala Gly Tyr Arg Pro Leu Ser
        435                 440                 445             
Ala Ser Ser Gln Ser Ser Leu Arg Ser Leu Ile Ser Ala Leu
    450                 455                 460         


<210> 8996
<211> 420
<212> PRT
<213> Homo sapiens

<400> 8996
Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro
 1               5                  10                  15      
Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly
            20                  25                  30          
Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln
        35                  40                  45              
Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp
    50                  55                  60                  
Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg
65                  70                  75                  80  
Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val
                85                  90                  95      
Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg
            100                 105                 110         
Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe
        115                 120                 125             
Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser
    130                 135                 140                 
Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly
145                 150                 155                 160 
Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser
                165                 170                 175     
Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp
            180                 185                 190         
Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg
        195                 200                 205             
Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr
    210                 215                 220                 
Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly
225                 230                 235                 240 
Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu
                245                 250                 255     
Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu
            260                 265                 270         
Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly
        275                 280                 285             
Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu
    290                 295                 300                 
Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala
305                 310                 315                 320 
Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro
                325                 330                 335     
Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val
            340                 345                 350         
Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Gly Ala
        355                 360                 365             
Val Cys Trp Leu Arg Glu Lys Gly Pro Arg Arg Trp Gly Leu Pro Gly
    370                 375                 380                 
Ala Pro Gly Glu Ala Gly Leu Cys Gly Thr Asn Ser Pro Glu Gly Trp
385                 390                 395                 400 
Pro Cys Pro Ala Pro Pro Gly Thr Pro Arg Leu Arg Val Leu Pro Arg
                405                 410                 415     
Ala Thr Gly Leu
            420 


<210> 8997
<211> 424
<212> PRT
<213> Homo sapiens

<400> 8997
Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro
 1               5                  10                  15      
Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly
            20                  25                  30          
Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln
        35                  40                  45              
Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp
    50                  55                  60                  
Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg
65                  70                  75                  80  
Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val
                85                  90                  95      
Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg
            100                 105                 110         
Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe
        115                 120                 125             
Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser
    130                 135                 140                 
Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly
145                 150                 155                 160 
Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser
                165                 170                 175     
Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp
            180                 185                 190         
Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg
        195                 200                 205             
Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr
    210                 215                 220                 
Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly
225                 230                 235                 240 
Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu
                245                 250                 255     
Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu
            260                 265                 270         
Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly
        275                 280                 285             
Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu
    290                 295                 300                 
Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala
305                 310                 315                 320 
Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro
                325                 330                 335     
Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val
            340                 345                 350         
Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Ala Arg
        355                 360                 365             
Val Phe Ser Thr Val Thr Ala Val Ser Val Leu Leu Leu Leu Leu Leu
    370                 375                 380                 
Gly Leu Leu Arg Pro Leu Arg Arg Arg Cys Gly Ala Leu Gly Gln Gly
385                 390                 395                 400 
Leu Arg Ala Asp Arg Trp Trp Gly Ala Gly Ala Pro Glu Gly Asn Arg
                405                 410                 415     
Ala Arg Lys Glu Leu Leu Gly Ser
            420                 


<210> 8998
<211> 399
<212> PRT
<213> Homo sapiens

<400> 8998
Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro
 1               5                  10                  15      
Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly
            20                  25                  30          
Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln
        35                  40                  45              
Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp
    50                  55                  60                  
Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg
65                  70                  75                  80  
Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val
                85                  90                  95      
Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg
            100                 105                 110         
Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe
        115                 120                 125             
Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser
    130                 135                 140                 
Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly
145                 150                 155                 160 
Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser
                165                 170                 175     
Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp
            180                 185                 190         
Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg
        195                 200                 205             
Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr
    210                 215                 220                 
Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly
225                 230                 235                 240 
Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu
                245                 250                 255     
Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu
            260                 265                 270         
Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly
        275                 280                 285             
Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu
    290                 295                 300                 
Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala
305                 310                 315                 320 
Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro
                325                 330                 335     
Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val
            340                 345                 350         
Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Gly Glu
        355                 360                 365             
Ala Gly Ala Arg Asp Gly Ser Glu Ser Gly Ser Arg Pro Leu Ala Pro
    370                 375                 380                 
Ile Leu Thr Ala Ala Val Cys Pro Gln Pro Gly Ser Ser Arg Arg
385                 390                 395                 


<210> 8999
<211> 635
<212> PRT
<213> Homo sapiens

<400> 8999
Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala Ser Gly Ala Ala Ala
 1               5                  10                  15      
Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Ser Thr
            20                  25                  30          
Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro Pro Asn Val Asp Arg
        35                  40                  45              
Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Ile Gln Ala Leu Gly
    50                  55                  60                  
Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser
65                  70                  75                  80  
Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu
                85                  90                  95      
Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly
            100                 105                 110         
Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser
        115                 120                 125             
Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu
    130                 135                 140                 
Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val
145                 150                 155                 160 
Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu
                165                 170                 175     
Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu
            180                 185                 190         
Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu
        195                 200                 205             
Ala Pro Asp Pro Leu Phe Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro
    210                 215                 220                 
Ala Pro Leu Val Leu Ser Phe Ser Gly Asn Pro Leu His Cys Asn Cys
225                 230                 235                 240 
Glu Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr
                245                 250                 255     
Cys Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro
            260                 265                 270         
Glu Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln
        275                 280                 285             
Arg Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala
    290                 295                 300                 
Leu Gly Asp Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg
305                 310                 315                 320 
Leu Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu
                325                 330                 335     
Glu Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile
            340                 345                 350         
Ala Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val
        355                 360                 365             
Leu Ala Leu Pro His Gly Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro
    370                 375                 380                 
Gly Pro Ser Asp Ile Ala Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu
385                 390                 395                 400 
Gly Thr Leu Glu Ser Glu Pro Ala Val Gln Val Thr Glu Val Thr Ala
                405                 410                 415     
Thr Ser Gly Leu Val Ser Trp Gly Pro Gly Arg Pro Ala Asp Pro Val
            420                 425                 430         
Trp Met Phe Gln Ile Gln Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile
        435                 440                 445             
Tyr Arg Ile Val Pro Ala Ser Ser His His Phe Leu Leu Lys His Leu
    450                 455                 460                 
Val Pro Gly Ala Asp Tyr Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala
465                 470                 475                 480 
Ala Gly Pro Ser Asp Leu Thr Ala Thr Arg Leu Leu Gly Cys Ala His
                485                 490                 495     
Phe Ser Thr Leu Pro Ala Ser Pro Leu Cys His Ala Leu Gln Ala His
            500                 505                 510         
Val Leu Gly Gly Thr Leu Thr Val Ala Val Gly Gly Val Leu Val Ala
        515                 520                 525             
Ala Leu Leu Val Phe Thr Val Ala Leu Leu Val Arg Gly Arg Gly Ala
    530                 535                 540                 
Gly Asn Gly Arg Leu Pro Leu Lys Leu Ser His Val Gln Ser Gln Thr
545                 550                 555                 560 
Asn Gly Gly Pro Ser Pro Thr Pro Lys Ala His Pro Pro Arg Ser Pro
                565                 570                 575     
Pro Pro Arg Pro Gln Arg Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly
            580                 585                 590         
Cys Tyr Gly Tyr Ala Arg Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser
        595                 600                 605             
His Ser Val His Gly Gly Leu Leu Gly Ala Gly Cys Arg Gly Val Gly
    610                 615                 620                 
Gly Ser Ala Glu Arg Leu Glu Glu Ser Val Val
625                 630                 635 


<210> 9000
<211> 1444
<212> PRT
<213> Homo sapiens

<400> 9000
Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln
 1               5                  10                  15      
Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Pro Gly Gly Cys
            20                  25                  30          
Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly
        35                  40                  45              
Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Thr Glu Lys Pro Met
    50                  55                  60                  
Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser
65                  70                  75                  80  
Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys
                85                  90                  95      
Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg
            100                 105                 110         
Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly
        115                 120                 125             
Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu
    130                 135                 140                 
Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe
145                 150                 155                 160 
Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr
                165                 170                 175     
Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala
            180                 185                 190         
Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn
        195                 200                 205             
Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys
    210                 215                 220                 
Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr
225                 230                 235                 240 
Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp
                245                 250                 255     
Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp
            260                 265                 270         
Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro
        275                 280                 285             
Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr
    290                 295                 300                 
Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile
305                 310                 315                 320 
Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu
                325                 330                 335     
Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro
            340                 345                 350         
Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly
        355                 360                 365             
Gly Thr Gly Pro Pro Gly Ala Pro Leu Thr Thr Arg Thr Lys Cys Ala
    370                 375                 380                 
Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala
385                 390                 395                 400 
Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg
                405                 410                 415     
Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln
            420                 425                 430         
Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr
        435                 440                 445             
Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu
    450                 455                 460                 
Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr
465                 470                 475                 480 
Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly
                485                 490                 495     
Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr
            500                 505                 510         
Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser
        515                 520                 525             
Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys
    530                 535                 540                 
Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr
545                 550                 555                 560 
Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro
                565                 570                 575     
Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro
            580                 585                 590         
Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr
        595                 600                 605             
Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr
    610                 615                 620                 
Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala
625                 630                 635                 640 
Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser
                645                 650                 655     
Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn
            660                 665                 670         
Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn
        675                 680                 685             
Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr
    690                 695                 700                 
Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val
705                 710                 715                 720 
Arg Leu Ala Thr Thr Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu
                725                 730                 735     
Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala
            740                 745                 750         
Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile
        755                 760                 765             
Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Ser Gln Arg
    770                 775                 780                 
Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu
785                 790                 795                 800 
Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala
                805                 810                 815     
Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly
            820                 825                 830         
Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile
        835                 840                 845             
Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro
    850                 855                 860                 
Arg Asp Gln Phe Gln Leu Ala Ile Arg Val Ala Asp Leu Leu Gln His
865                 870                 875                 880 
Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr
                885                 890                 895     
Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu
            900                 905                 910         
Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp
        915                 920                 925             
His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp
    930                 935                 940                 
Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr
945                 950                 955                 960 
Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg
                965                 970                 975     
Met Ile Trp Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu
            980                 985                 990         
Val Glu Val Gly Arg Val Lys Cys Val Arg Tyr Trp Pro Asp Asp Thr
        995                 1000                1005            
Glu Val Tyr Gly Asp Ile Lys Val Thr Leu Ile Glu Thr Glu Pro Leu
    1010                1015                1020                
Ala Glu Tyr Val Ile Arg Thr Phe Thr Val Gln Lys Lys Gly Tyr His
1025                1030                1035                1040
Glu Ile Arg Glu Leu Arg Leu Phe His Phe Thr Ser Trp Pro Asp His
                1045                1050                1055    
Gly Val Pro Cys Tyr Ala Thr Gly Leu Leu Gly Phe Val Arg Gln Val
            1060                1065                1070        
Lys Phe Leu Asn Pro Pro Glu Ala Gly Pro Ile Val Val His Cys Ser
        1075                1080                1085            
Ala Gly Ala Gly Arg Thr Gly Cys Phe Ile Ala Ile Asp Thr Met Leu
    1090                1095                1100                
Asp Met Ala Glu Asn Glu Gly Val Val Asp Ile Phe Asn Cys Val Arg
1105                1110                1115                1120
Glu Leu Arg Ala Gln Arg Val Asn Leu Val Gln Thr Glu Glu Gln Tyr
                1125                1130                1135    
Val Phe Val His Asp Ala Ile Leu Glu Ala Cys Leu Cys Gly Asn Thr
            1140                1145                1150        
Ala Ile Pro Val Cys Glu Phe Arg Ser Leu Tyr Tyr Asn Ile Ser Arg
        1155                1160                1165            
Leu Asp Pro Gln Thr Asn Ser Ser Gln Ile Lys Asp Glu Phe Gln Thr
    1170                1175                1180                
Leu Asn Ile Val Thr Pro Arg Val Arg Pro Glu Asp Cys Ser Ile Gly
1185                1190                1195                1200
Leu Leu Pro Arg Asn His Asp Lys Asn Arg Ser Met Asp Val Leu Pro
                1205                1210                1215    
Leu Asp Arg Cys Leu Pro Phe Leu Ile Ser Val Asp Gly Glu Ser Ser
            1220                1225                1230        
Asn Tyr Ile Asn Ala Ala Leu Met Asp Ser His Lys Gln Pro Ala Ala
        1235                1240                1245            
Phe Val Val Thr Gln His Pro Leu Pro Asn Thr Val Ala Asp Phe Trp
    1250                1255                1260                
Arg Leu Val Phe Asp Tyr Asn Cys Ser Ser Val Val Met Leu Asn Glu
1265                1270                1275                1280
Met Asp Thr Ala Gln Phe Cys Met Gln Tyr Trp Pro Glu Lys Thr Ser
                1285                1290                1295    
Gly Cys Tyr Gly Pro Ile Gln Val Glu Phe Val Ser Ala Asp Ile Asp
            1300                1305                1310        
Glu Asp Ile Ile His Arg Ile Phe Arg Ile Cys Asn Met Ala Arg Pro
        1315                1320                1325            
Gln Asp Gly Tyr Arg Ile Val Gln His Leu Gln Tyr Ile Gly Trp Pro
    1330                1335                1340                
Ala Tyr Arg Asp Thr Pro Pro Ser Lys Arg Ser Leu Leu Lys Val Val
1345                1350                1355                1360
Arg Arg Leu Glu Lys Trp Gln Glu Gln Tyr Asp Gly Arg Glu Gly Arg
                1365                1370                1375    
Thr Val Val His Cys Leu Asn Gly Gly Gly Arg Ser Gly Thr Phe Cys
            1380                1385                1390        
Ala Ile Cys Ser Val Cys Glu Met Ile Gln Gln Gln Asn Ile Ile Asp
        1395                1400                1405            
Val Phe His Ile Val Lys Thr Leu Arg Asn Asn Lys Ser Asn Met Val
    1410                1415                1420                
Glu Thr Leu Glu Gln Tyr Lys Phe Val Tyr Glu Val Ala Leu Glu Tyr
1425                1430                1435                1440
Leu Ser Ser Phe
                


<210> 9001
<211> 1463
<212> PRT
<213> Homo sapiens

<400> 9001
Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln
 1               5                  10                  15      
Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Pro Gly Gly Cys
            20                  25                  30          
Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly
        35                  40                  45              
Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Thr Glu Lys Pro Met
    50                  55                  60                  
Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser
65                  70                  75                  80  
Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys
                85                  90                  95      
Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg
            100                 105                 110         
Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly
        115                 120                 125             
Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu
    130                 135                 140                 
Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe
145                 150                 155                 160 
Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr
                165                 170                 175     
Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala
            180                 185                 190         
Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn
        195                 200                 205             
Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys
    210                 215                 220                 
Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr
225                 230                 235                 240 
Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp
                245                 250                 255     
Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp
            260                 265                 270         
Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro
        275                 280                 285             
Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr
    290                 295                 300                 
Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile
305                 310                 315                 320 
Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu
                325                 330                 335     
Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro
            340                 345                 350         
Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly
        355                 360                 365             
Gly Thr Gly Pro Pro Gly Ala Pro Leu Thr Thr Arg Thr Lys Cys Ala
    370                 375                 380                 
Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala
385                 390                 395                 400 
Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg
                405                 410                 415     
Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln
            420                 425                 430         
Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr
        435                 440                 445             
Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu
    450                 455                 460                 
Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr
465                 470                 475                 480 
Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly
                485                 490                 495     
Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr
            500                 505                 510         
Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser
        515                 520                 525             
Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys
    530                 535                 540                 
Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr
545                 550                 555                 560 
Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro
                565                 570                 575     
Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro
            580                 585                 590         
Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr
        595                 600                 605             
Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr
    610                 615                 620                 
Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala
625                 630                 635                 640 
Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser
                645                 650                 655     
Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn
            660                 665                 670         
Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn
        675                 680                 685             
Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr
    690                 695                 700                 
Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val
705                 710                 715                 720 
Arg Leu Ala Thr Lys Ala Pro Met Gly Ser Ala Gln Val Thr Pro Gly
                725                 730                 735     
Thr Pro Leu Cys Leu Leu Thr Thr Gly Ala Ser Thr Gln Asn Ser Asn
            740                 745                 750         
Thr Val Glu Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly
        755                 760                 765             
Val Ile Ala Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met
    770                 775                 780                 
Leu Thr Ile Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu
785                 790                 795                 800 
Ser Gln Arg Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala
                805                 810                 815     
Gln Arg Glu Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys
            820                 825                 830         
Leu Ser Ala Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp
        835                 840                 845             
Val Asn Gly Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr
    850                 855                 860                 
Leu Thr Ile Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met
865                 870                 875                 880 
Ser Tyr Pro Arg Asp Gln Phe Gln Leu Ala Ile Arg Val Ala Asp Leu
                885                 890                 895     
Leu Gln His Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys
            900                 905                 910         
Glu Glu Tyr Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr
        915                 920                 925             
Ala Lys Glu Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile
    930                 935                 940                 
Ser Tyr Asp His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro
945                 950                 955                 960 
His Ser Asp Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro
                965                 970                 975     
Arg His Tyr Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp
            980                 985                 990         
Phe Trp Arg Met Ile Trp Gln Glu Asn Ser Ala Ser Ile Val Met Val
        995                 1000                1005            
Thr Asn Leu Val Glu Val Gly Arg Val Lys Cys Val Arg Tyr Trp Pro
    1010                1015                1020                
Asp Asp Thr Glu Val Tyr Gly Asp Ile Lys Val Thr Leu Ile Glu Thr
1025                1030                1035                1040
Glu Pro Leu Ala Glu Tyr Val Ile Arg Thr Phe Thr Val Gln Lys Lys
                1045                1050                1055    
Gly Tyr His Glu Ile Arg Glu Leu Arg Leu Phe His Phe Thr Ser Trp
            1060                1065                1070        
Pro Asp His Gly Val Pro Cys Tyr Ala Thr Gly Leu Leu Gly Phe Val
        1075                1080                1085            
Arg Gln Val Lys Phe Leu Asn Pro Pro Glu Ala Gly Pro Ile Val Val
    1090                1095                1100                
His Cys Ser Ala Gly Ala Gly Arg Thr Gly Cys Phe Ile Ala Ile Asp
1105                1110                1115                1120
Thr Met Leu Asp Met Ala Glu Asn Glu Gly Val Val Asp Ile Phe Asn
                1125                1130                1135    
Cys Val Arg Glu Leu Arg Ala Gln Arg Val Asn Leu Val Gln Thr Glu
            1140                1145                1150        
Glu Gln Tyr Val Phe Val His Asp Ala Ile Leu Glu Ala Cys Leu Cys
        1155                1160                1165            
Gly Asn Thr Ala Ile Pro Val Cys Glu Phe Arg Ser Leu Tyr Tyr Asn
    1170                1175                1180                
Ile Ser Arg Leu Asp Pro Gln Thr Asn Ser Ser Gln Ile Lys Asp Glu
1185                1190                1195                1200
Phe Gln Thr Leu Asn Ile Val Thr Pro Arg Val Arg Pro Glu Asp Cys
                1205                1210                1215    
Ser Ile Gly Leu Leu Pro Arg Asn His Asp Lys Asn Arg Ser Met Asp
            1220                1225                1230        
Val Leu Pro Leu Asp Arg Cys Leu Pro Phe Leu Ile Ser Val Asp Gly
        1235                1240                1245            
Glu Ser Ser Asn Tyr Ile Asn Ala Ala Leu Met Asp Ser His Lys Gln
    1250                1255                1260                
Pro Ala Ala Phe Val Val Thr Gln His Pro Leu Pro Asn Thr Val Ala
1265                1270                1275                1280
Asp Phe Trp Arg Leu Val Phe Asp Tyr Asn Cys Ser Ser Val Val Met
                1285                1290                1295    
Leu Asn Glu Met Asp Thr Ala Gln Phe Cys Met Gln Tyr Trp Pro Glu
            1300                1305                1310        
Lys Thr Ser Gly Cys Tyr Gly Pro Ile Gln Val Glu Phe Val Ser Ala
        1315                1320                1325            
Asp Ile Asp Glu Asp Ile Ile His Arg Ile Phe Arg Ile Cys Asn Met
    1330                1335                1340                
Ala Arg Pro Gln Asp Gly Tyr Arg Ile Val Gln His Leu Gln Tyr Ile
1345                1350                1355                1360
Gly Trp Pro Ala Tyr Arg Asp Thr Pro Pro Ser Lys Arg Ser Leu Leu
                1365                1370                1375    
Lys Val Val Arg Arg Leu Glu Lys Trp Gln Glu Gln Tyr Asp Gly Arg
            1380                1385                1390        
Glu Gly Arg Thr Val Val His Cys Leu Asn Gly Gly Gly Arg Ser Gly
        1395                1400                1405            
Thr Phe Cys Ala Ile Cys Ser Val Cys Glu Met Ile Gln Gln Gln Asn
    1410                1415                1420                
Ile Ile Asp Val Phe His Ile Val Lys Thr Leu Arg Asn Asn Lys Ser
1425                1430                1435                1440
Asn Met Val Glu Thr Leu Glu Gln Tyr Lys Phe Val Tyr Glu Val Ala
                1445                1450                1455    
Leu Glu Tyr Leu Ser Ser Phe
            1460            


<210> 9002
<211> 1444
<212> PRT
<213> Homo sapiens

<400> 9002
Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln
 1               5                  10                  15      
Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Pro Gly Gly Cys
            20                  25                  30          
Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly
        35                  40                  45              
Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Thr Glu Lys Pro Met
    50                  55                  60                  
Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser
65                  70                  75                  80  
Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys
                85                  90                  95      
Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg
            100                 105                 110         
Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly
        115                 120                 125             
Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu
    130                 135                 140                 
Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe
145                 150                 155                 160 
Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr
                165                 170                 175     
Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala
            180                 185                 190         
Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn
        195                 200                 205             
Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys
    210                 215                 220                 
Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr
225                 230                 235                 240 
Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp
                245                 250                 255     
Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp
            260                 265                 270         
Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro
        275                 280                 285             
Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr
    290                 295                 300                 
Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile
305                 310                 315                 320 
Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu
                325                 330                 335     
Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro
            340                 345                 350         
Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly
        355                 360                 365             
Gly Thr Gly Pro Pro Gly Ala Pro Leu Thr Thr Arg Thr Lys Cys Ala
    370                 375                 380                 
Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala
385                 390                 395                 400 
Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg
                405                 410                 415     
Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln
            420                 425                 430         
Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr
        435                 440                 445             
Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu
    450                 455                 460                 
Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr
465                 470                 475                 480 
Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly
                485                 490                 495     
Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr
            500                 505                 510         
Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser
        515                 520                 525             
Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys
    530                 535                 540                 
Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr
545                 550                 555                 560 
Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro
                565                 570                 575     
Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro
            580                 585                 590         
Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr
        595                 600                 605             
Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr
    610                 615                 620                 
Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala
625                 630                 635                 640 
Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser
                645                 650                 655     
Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn
            660                 665                 670         
Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn
        675                 680                 685             
Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr
    690                 695                 700                 
Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val
705                 710                 715                 720 
Arg Leu Ala Thr Lys Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu
                725                 730                 735     
Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala
            740                 745                 750         
Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile
        755                 760                 765             
Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Ser Gln Arg
    770                 775                 780                 
Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu
785                 790                 795                 800 
Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala
                805                 810                 815     
Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly
            820                 825                 830         
Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile
        835                 840                 845             
Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro
    850                 855                 860                 
Arg Asp Gln Phe Gln Leu Ala Ile Arg Val Ala Asp Leu Leu Gln His
865                 870                 875                 880 
Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr
                885                 890                 895     
Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu
            900                 905                 910         
Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp
        915                 920                 925             
His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp
    930                 935                 940                 
Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr
945                 950                 955                 960 
Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg
                965                 970                 975     
Met Ile Trp Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu
            980                 985                 990         
Val Glu Val Gly Arg Val Lys Cys Val Arg Tyr Trp Pro Asp Asp Thr
        995                 1000                1005            
Glu Val Tyr Gly Asp Ile Lys Val Thr Leu Ile Glu Thr Glu Pro Leu
    1010                1015                1020                
Ala Glu Tyr Val Ile Arg Thr Phe Thr Val Gln Lys Lys Gly Tyr His
1025                1030                1035                1040
Glu Ile Arg Glu Leu Arg Leu Phe His Phe Thr Ser Trp Pro Asp His
                1045                1050                1055    
Gly Val Pro Cys Tyr Ala Thr Gly Leu Leu Gly Phe Val Arg Gln Val
            1060                1065                1070        
Lys Phe Leu Asn Pro Pro Glu Ala Gly Pro Ile Val Val His Cys Ser
        1075                1080                1085            
Ala Gly Ala Gly Arg Thr Gly Cys Phe Ile Ala Ile Asp Thr Met Leu
    1090                1095                1100                
Asp Met Ala Glu Asn Glu Gly Val Val Asp Ile Phe Asn Cys Val Arg
1105                1110                1115                1120
Glu Leu Arg Ala Gln Arg Val Asn Leu Val Gln Thr Glu Glu Gln Tyr
                1125                1130                1135    
Val Phe Val His Asp Ala Ile Leu Glu Ala Cys Leu Cys Gly Asn Thr
            1140                1145                1150        
Ala Ile Pro Val Cys Glu Phe Arg Ser Leu Tyr Tyr Asn Ile Ser Arg
        1155                1160                1165            
Leu Asp Pro Gln Thr Asn Ser Ser Gln Ile Lys Asp Glu Phe Gln Thr
    1170                1175                1180                
Leu Asn Ile Val Thr Pro Arg Val Arg Pro Glu Asp Cys Ser Ile Gly
1185                1190                1195                1200
Leu Leu Pro Arg Asn His Asp Lys Asn Arg Ser Met Asp Val Leu Pro
                1205                1210                1215    
Leu Asp Arg Cys Leu Pro Phe Leu Ile Ser Val Asp Gly Glu Ser Ser
            1220                1225                1230        
Asn Tyr Ile Asn Ala Ala Leu Met Asp Ser His Lys Gln Pro Ala Ala
        1235                1240                1245            
Phe Val Val Thr Gln His Pro Leu Pro Asn Thr Val Ala Asp Phe Trp
    1250                1255                1260                
Arg Leu Val Phe Asp Tyr Asn Cys Ser Ser Val Val Met Leu Asn Glu
1265                1270                1275                1280
Met Asp Thr Ala Gln Phe Cys Met Gln Tyr Trp Pro Glu Lys Thr Ser
                1285                1290                1295    
Gly Cys Tyr Gly Pro Ile Gln Val Glu Phe Val Ser Ala Asp Ile Asp
            1300                1305                1310        
Glu Asp Ile Ile His Arg Ile Phe Arg Ile Cys Asn Met Ala Arg Pro
        1315                1320                1325            
Gln Asp Gly Tyr Arg Ile Val Gln His Leu Gln Tyr Ile Gly Trp Pro
    1330                1335                1340                
Ala Tyr Arg Asp Thr Pro Pro Ser Lys Arg Ser Leu Leu Lys Val Val
1345                1350                1355                1360
Arg Arg Leu Glu Lys Trp Gln Glu Gln Tyr Asp Gly Arg Glu Gly Arg
                1365                1370                1375    
Thr Val Val His Cys Leu Asn Gly Gly Gly Arg Ser Gly Thr Phe Cys
            1380                1385                1390        
Ala Ile Cys Ser Val Cys Glu Met Ile Gln Gln Gln Asn Ile Ile Asp
        1395                1400                1405            
Val Phe His Ile Val Lys Thr Leu Arg Asn Asn Lys Ser Asn Met Val
    1410                1415                1420                
Glu Thr Leu Glu Gln Tyr Lys Phe Val Tyr Glu Val Ala Leu Glu Tyr
1425                1430                1435                1440
Leu Ser Ser Phe
                


<210> 9003
<211> 266
<212> PRT
<213> Homo sapiens

<400> 9003
Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser
 1               5                  10                  15      
Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp
            20                  25                  30          
Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val
        35                  40                  45              
Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu
    50                  55                  60                  
Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn
65                  70                  75                  80  
Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu
                85                  90                  95      
Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser
            100                 105                 110         
Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr
        115                 120                 125             
Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala
    130                 135                 140                 
Asp Ser Tyr Lys Val Gly Cys Ala Val Gln Phe Cys Pro Lys Val Ser
145                 150                 155                 160 
Gly Phe Asp Ala Leu Ser Asn Gly Ala His Phe Ile Cys Asn Tyr Gly
                165                 170                 175     
Pro Gly Gly Asn Tyr Pro Thr Trp Pro Tyr Lys Arg Gly Ala Thr Cys
            180                 185                 190         
Ser Ala Cys Pro Asn Asn Asp Lys Cys Leu Asp Asn Leu Cys Val Asn
        195                 200                 205             
Arg Gln Arg Asp Gln Val Lys Arg Tyr Tyr Ser Val Val Tyr Pro Gly
    210                 215                 220                 
Trp Pro Ile Tyr Pro Arg Asn Arg Tyr Thr Ser Leu Phe Leu Ile Val
225                 230                 235                 240 
Asn Ser Val Ile Leu Ile Leu Ser Val Ile Ile Thr Ile Leu Val Gln
                245                 250                 255     
His Lys Tyr Pro Asn Leu Val Leu Leu Asp
            260                 265     


<210> 9004
<211> 647
<212> PRT
<213> Homo sapiens

<400> 9004
Met Leu Ser Gly Ala Ala Gly Ala Ala Arg Arg Gly Gly Ala Ala Leu
 1               5                  10                  15      
Ala Pro Ser Leu Thr Arg Ser Leu Ala Gly Thr His Ala Gly Ala Asp
            20                  25                  30          
Ser Cys Ala Gly Ala Asp Lys Gly Ser His Lys Glu Thr Ile Glu Glu
        35                  40                  45              
Arg Asp Lys Arg Gln Gln Arg Gln Gln Arg Gln Arg Gln His Gln Gly
    50                  55                  60                  
Cys Gly Ala Ala Gly Ser Gly Ser Asp Ser Pro Thr Ser Gly Pro His
65                  70                  75                  80  
Pro Val Pro Val Leu Phe Pro Leu Ala Leu Ser Leu Glu Glu Gln Pro
                85                  90                  95      
Leu Pro Pro Leu Pro Leu Gly Arg Ala Pro Gly Leu Leu Ala Arg Glu
            100                 105                 110         
Gly Gln Gly Arg Glu Ala Leu Ala Ser Pro Ser Ser Arg Gly Gln Met
        115                 120                 125             
Pro Ile Glu Ile Val Cys Lys Ile Lys Phe Ala Glu Glu Asp Ala Lys
    130                 135                 140                 
Pro Lys Glu Lys Glu Ala Gly Asp Glu Gln Ser Leu Leu Gly Ala Val
145                 150                 155                 160 
Ala Pro Gly Ala Ala Pro Arg Asp Leu Ala Thr Phe Ala Ser Thr Ser
                165                 170                 175     
Thr Leu His Gly Leu Gly Arg Ala Cys Gly Pro Gly Pro His Gly Leu
            180                 185                 190         
Arg Arg Thr Leu Trp Ala Leu Ala Leu Leu Thr Ser Leu Ala Ala Phe
        195                 200                 205             
Leu Tyr Gln Ala Ala Gly Leu Ala Arg Gly Tyr Leu Thr Arg Pro His
    210                 215                 220                 
Leu Val Ala Met Asp Pro Ala Ala Pro Ala Pro Val Ala Gly Phe Pro
225                 230                 235                 240 
Ala Val Thr Leu Cys Asn Ile Asn Arg Phe Arg His Ser Ala Leu Ser
                245                 250                 255     
Asp Ala Asp Ile Phe His Leu Ala Asn Leu Thr Gly Leu Pro Pro Lys
            260                 265                 270         
Asp Arg Asp Gly His Arg Ala Ala Gly Leu Arg Tyr Pro Glu Pro Asp
        275                 280                 285             
Met Val Asp Ile Leu Asn Arg Thr Gly His Gln Leu Ala Asp Met Leu
    290                 295                 300                 
Lys Ser Cys Asn Phe Ser Gly His His Cys Ser Ala Ser Asn Phe Ser
305                 310                 315                 320 
Val Val Tyr Thr Arg Tyr Gly Lys Cys Tyr Thr Phe Asn Ala Asp Pro
                325                 330                 335     
Arg Ser Ser Leu Pro Ser Arg Ala Gly Gly Met Gly Ser Gly Leu Glu
            340                 345                 350         
Ile Met Leu Asp Ile Gln Gln Glu Glu Tyr Leu Pro Ile Trp Arg Glu
        355                 360                 365             
Thr Asn Glu Thr Ser Phe Glu Ala Gly Ile Arg Val Gln Ile His Ser
    370                 375                 380                 
Gln Glu Glu Pro Pro Tyr Ile His Gln Leu Gly Phe Gly Val Ser Pro
385                 390                 395                 400 
Gly Phe Gln Thr Phe Val Ser Cys Gln Glu Gln Arg Leu Thr Tyr Leu
                405                 410                 415     
Pro Gln Pro Trp Gly Asn Cys Arg Ala Glu Ser Glu Leu Arg Glu Pro
            420                 425                 430         
Glu Leu Gln Gly Tyr Ser Ala Tyr Ser Val Ser Ala Cys Arg Leu Arg
        435                 440                 445             
Cys Glu Lys Glu Ala Val Leu Gln Arg Cys His Cys Arg Met Val His
    450                 455                 460                 
Met Pro Asp Ser Leu Gly Gly Gly Pro Glu Gly Pro Cys Phe Cys Pro
465                 470                 475                 480 
Thr Pro Cys Asn Leu Thr Arg Tyr Gly Lys Glu Ile Ser Met Val Arg
                485                 490                 495     
Ile Pro Asn Arg Gly Ser Ala Arg Tyr Leu Ala Arg Lys Tyr Asn Arg
            500                 505                 510         
Asn Glu Thr Tyr Ile Arg Glu Asn Phe Leu Val Leu Asp Val Phe Phe
        515                 520                 525             
Glu Ala Leu Thr Ser Glu Ala Met Glu Gln Arg Ala Ala Tyr Gly Leu
    530                 535                 540                 
Ser Ala Leu Leu Gly Asp Leu Gly Gly Gln Met Gly Leu Phe Ile Gly
545                 550                 555                 560 
Ala Ser Ile Leu Thr Leu Leu Glu Ile Leu Asp Tyr Ile Tyr Glu Val
                565                 570                 575     
Ser Trp Asp Arg Leu Lys Arg Val Trp Arg Arg Pro Lys Thr Pro Leu
            580                 585                 590         
Arg Thr Ser Thr Gly Gly Ile Ser Thr Leu Gly Leu Gln Glu Leu Lys
        595                 600                 605             
Glu Gln Ser Pro Cys Pro Ser Leu Gly Arg Ala Glu Gly Gly Gly Val
    610                 615                 620                 
Ser Ser Leu Leu Pro Asn His His His Pro His Gly Pro Pro Gly Gly
625                 630                 635                 640 
Leu Phe Glu Asp Phe Ala Cys
                645         


<210> 9005
<211> 440
<212> PRT
<213> Homo sapiens

<400> 9005
Met Glu Tyr Gln Ile Leu Lys Met Ser Leu Cys Leu Phe Ile Leu Leu
 1               5                  10                  15      
Phe Leu Thr Pro Gly Ile Leu Cys Ile Cys Pro Leu Gln Cys Ile Cys
            20                  25                  30          
Thr Glu Arg His Arg His Val Asp Cys Ser Gly Arg Asn Leu Ser Thr
        35                  40                  45              
Leu Pro Ser Gly Leu Gln Glu Asn Ile Ile His Leu Asn Leu Ser Tyr
    50                  55                  60                  
Asn His Phe Thr Asp Leu His Asn Gln Leu Thr Gln Tyr Thr Asn Leu
65                  70                  75                  80  
Arg Thr Leu Asp Ile Ser Asn Asn Arg Leu Glu Ser Leu Pro Ala His
                85                  90                  95      
Leu Pro Arg Ser Leu Trp Asn Met Ser Ala Ala Asn Asn Asn Ile Lys
            100                 105                 110         
Leu Leu Asp Lys Ser Asp Thr Ala Tyr Gln Trp Asn Leu Lys Tyr Leu
        115                 120                 125             
Asp Val Ser Lys Asn Met Leu Glu Lys Val Val Leu Ile Lys Asn Thr
    130                 135                 140                 
Leu Arg Ser Leu Glu Val Leu Asn Leu Ser Ser Asn Lys Leu Trp Thr
145                 150                 155                 160 
Val Pro Thr Asn Met Pro Ser Lys Leu His Ile Val Asp Leu Ser Asn
                165                 170                 175     
Asn Ser Leu Thr Gln Ile Leu Pro Gly Thr Leu Ile Asn Leu Thr Asn
            180                 185                 190         
Leu Thr His Leu Tyr Leu His Asn Asn Lys Phe Thr Phe Ile Pro Asp
        195                 200                 205             
Gln Ser Phe Asp Gln Leu Phe Gln Leu Gln Glu Ile Thr Leu Tyr Asn
    210                 215                 220                 
Asn Arg Trp Ser Cys Asp His Lys Gln Asn Ile Thr Tyr Leu Leu Lys
225                 230                 235                 240 
Trp Met Met Glu Thr Lys Ala His Val Ile Gly Thr Pro Cys Ser Thr
                245                 250                 255     
Gln Ile Ser Ser Leu Lys Glu His Asn Met Tyr Pro Thr Pro Ser Gly
            260                 265                 270         
Phe Thr Ser Ser Leu Phe Thr Val Ser Gly Met Gln Thr Val Asp Thr
        275                 280                 285             
Ile Asn Ser Leu Ser Val Val Thr Gln Pro Lys Val Thr Lys Ile Pro
    290                 295                 300                 
Lys Gln Tyr Arg Thr Lys Glu Thr Thr Phe Gly Ala Thr Leu Ser Lys
305                 310                 315                 320 
Asp Thr Thr Phe Thr Ser Thr Asp Lys Ala Phe Val Pro Tyr Pro Glu
                325                 330                 335     
Asp Thr Ser Thr Glu Thr Ile Asn Ser His Glu Ala Ala Ala Ala Thr
            340                 345                 350         
Leu Thr Ile His Leu Gln Asp Gly Met Val Thr Asn Thr Ser Leu Thr
        355                 360                 365             
Ser Ser Thr Lys Ser Ser Pro Thr Pro Met Thr Leu Ser Ile Thr Ser
    370                 375                 380                 
Gly Met Pro Asn Asn Phe Ser Glu Met Pro Gln Gln Ser Thr Thr Leu
385                 390                 395                 400 
Asn Leu Trp Arg Glu Glu Thr Thr Thr Asn Val Lys Thr Pro Leu Pro
                405                 410                 415     
Ser Val Ala Asn Ala Trp Lys Val Asn Ala Ser Phe Leu Leu Leu Leu
            420                 425                 430         
Asn Val Val Val Met Leu Ala Val
        435                 440 


<210> 9006
<211> 500
<212> PRT
<213> Homo sapiens

<400> 9006
Met Leu Leu Thr Glu Thr Trp Met Cys Cys Tyr Cys Phe Leu Thr Leu
 1               5                  10                  15      
Pro Thr Thr Trp Pro Asn Asp Asp Glu Val Asp Lys Val Asn Gln Tyr
            20                  25                  30          
Gln Arg Leu Ser Leu Glu Asn Leu Glu Lys Ile Glu Ile Gly Pro Glu
        35                  40                  45              
Pro Thr Leu Phe Gly Lys Pro Lys Phe Ser Cys Met Arg Leu His Tyr
    50                  55                  60                  
Arg Tyr Lys Glu Ala Ser Gly Tyr Phe His Thr Leu Arg Ala Val Met
65                  70                  75                  80  
Arg Asn Pro Glu Glu Asp Gly Lys Asp Thr Leu Gln Cys Ile Ala Glu
                85                  90                  95      
Met Leu Gln Ile Thr Lys Gln Ala Met Gly Ser Asp Leu Pro Ile Ile
            100                 105                 110         
Glu Lys Lys Leu Glu Arg Lys Ser Ser Lys Pro His Glu Asp Ile Ile
        115                 120                 125             
Gly Ile Arg Ser Gln Asn Gln Gly Ser Leu Ala Gln Gly Lys Asn Phe
    130                 135                 140                 
Leu Met Ser Lys Phe Ser Ser Leu Asn Gln Lys Val Lys Gln Thr Lys
145                 150                 155                 160 
Ser Asn Val Asn Ile Gly Asn Leu Arg Lys Leu Gly Asn Phe Thr Lys
                165                 170                 175     
Pro Glu Met Lys Val Asn Phe Leu Lys Pro Asn Leu Lys Val Asn Leu
            180                 185                 190         
Trp Lys Ser Asp Ser Ser Leu Glu Thr Met Glu Asn Thr Gly Val Met
        195                 200                 205             
Asp Lys Val Gln Ala Glu Ser Asp Gly Asp Met Ser Ser Asp Asn Asp
    210                 215                 220                 
Ser Tyr His Ser Asp Glu Phe Leu Thr Asn Ser Lys Ser Asp Glu Asp
225                 230                 235                 240 
Arg Gln Leu Ala Asn Ser Leu Glu Ser Val Gly Pro Ile Asp Tyr Val
                245                 250                 255     
Leu Pro Ser Cys Gly Ile Ile Ala Ser Ala Pro Arg Leu Gly Ser Arg
            260                 265                 270         
Ser Gln Ser Leu Ser Ser Thr Asp Ser Ser Val His Ala Pro Ser Glu
        275                 280                 285             
Ile Thr Val Ala His Gly Ser Gly Leu Gly Lys Gly Gln Glu Ser Pro
    290                 295                 300                 
Leu Lys Lys Ser Pro Ser Ala Gly Asp Val His Ile Leu Thr Gly Phe
305                 310                 315                 320 
Ala Lys Pro Met Asp Ile Tyr Cys His Arg Phe Val Gln Asp Ala Gln
                325                 330                 335     
Asn Lys Val Thr His Leu Ser Glu Thr Arg Ser Val Ser Gln Gln Ala
            340                 345                 350         
Ser Gln Glu Arg Asn Gln Met Thr Asn Gln Val Ser Asn Glu Thr Gln
        355                 360                 365             
Ser Glu Ser Thr Glu Gln Thr Pro Ser Arg Pro Ser Gln Leu Asp Val
    370                 375                 380                 
Ser Leu Ser Ala Thr Gly Pro Gln Phe Leu Ser Val Glu Pro Ala His
385                 390                 395                 400 
Ser Val Ala Ser Gln Lys Thr Pro Thr Ser Ala Ser Ser Met Leu Glu
                405                 410                 415     
Leu Glu Thr Gly Leu His Val Thr Pro Ser Pro Ser Glu Ser Ser Ser
            420                 425                 430         
Ser Arg Ala Val Ser Pro Phe Ala Lys Ile Arg Ser Ser Met Val Gln
        435                 440                 445             
Val Ala Ser Ile Thr Gln Ala Gly Leu Thr His Gly Ile Asn Phe Ala
    450                 455                 460                 
Val Ser Lys Val Gln Lys Ser Pro Pro Glu Pro Glu Ile Ile Asn Gln
465                 470                 475                 480 
Val Gln Gln Asn Glu Leu Lys Lys Met Phe Ile Gln Cys Gln Thr Arg
                485                 490                 495     
Ile Ile Gln Ile
            500 


<210> 9007
<211> 349
<212> PRT
<213> Homo sapiens

<400> 9007
Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln
 1               5                  10                  15      
Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30          
Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly
        35                  40                  45              
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly
    50                  55                  60                  
Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile
65                  70                  75                  80  
Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95      
Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val
            100                 105                 110         
Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn
        115                 120                 125             
Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr
    130                 135                 140                 
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145                 150                 155                 160 
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr
                165                 170                 175     
Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190         
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
        195                 200                 205             
Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn
    210                 215                 220                 
Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240 
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn
                245                 250                 255     
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser
            260                 265                 270         
Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn
        275                 280                 285             
Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser
    290                 295                 300                 
Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp
305                 310                 315                 320 
Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val
                325                 330                 335     
Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile
            340                 345                 


<210> 9008
<211> 860
<212> PRT
<213> Homo sapiens

<400> 9008
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15      
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30          
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45              
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60                  
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80  
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95      
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110         
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125             
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140                 
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160 
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175     
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190         
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205             
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220                 
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240 
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255     
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270         
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285             
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300                 
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320 
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335     
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350         
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365             
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380                 
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400 
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415     
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430         
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445             
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460                 
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480 
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495     
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510         
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525             
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540                 
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560 
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575     
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590         
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605             
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620                 
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640 
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655     
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670         
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685             
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700                 
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720 
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735     
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750         
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765             
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780                 
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800 
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815     
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830         
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845             
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860 


<210> 9009
<211> 545
<212> PRT
<213> Homo sapiens

<400> 9009
Met Pro Pro Phe Leu Leu Leu Thr Cys Leu Phe Ile Thr Gly Thr Ser
 1               5                  10                  15      
Val Ser Pro Val Ala Leu Asp Pro Cys Ser Ala Tyr Ile Ser Leu Asn
            20                  25                  30          
Glu Pro Trp Arg Asn Thr Asp His Gln Leu Asp Glu Ser Gln Gly Pro
        35                  40                  45              
Pro Leu Cys Asp Asn His Val Asn Gly Glu Trp Tyr His Phe Thr Gly
    50                  55                  60                  
Met Ala Gly Asp Ala Met Pro Thr Phe Cys Ile Pro Glu Asn His Cys
65                  70                  75                  80  
Gly Thr His Ala Pro Val Trp Leu Asn Gly Ser His Pro Leu Glu Gly
                85                  90                  95      
Asp Gly Ile Val Gln Arg Gln Ala Cys Ala Ser Phe Asn Gly Asn Cys
            100                 105                 110         
Cys Leu Trp Asn Thr Thr Val Glu Val Lys Ala Cys Pro Gly Gly Tyr
        115                 120                 125             
Tyr Val Tyr Arg Leu Thr Lys Pro Ser Val Cys Phe His Val Tyr Cys
    130                 135                 140                 
Gly His Phe Tyr Asp Ile Cys Asp Glu Asp Cys His Gly Ser Cys Ser
145                 150                 155                 160 
Asp Thr Ser Glu Cys Thr Cys Ala Pro Gly Thr Val Leu Gly Pro Asp
                165                 170                 175     
Arg Gln Thr Cys Phe Asp Glu Asn Glu Cys Glu Gln Asn Asn Gly Gly
            180                 185                 190         
Cys Ser Glu Ile Cys Val Asn Leu Lys Asn Ser Tyr Arg Cys Glu Cys
        195                 200                 205             
Gly Val Gly Arg Val Leu Arg Ser Asp Gly Lys Thr Cys Glu Asp Val
    210                 215                 220                 
Glu Gly Cys His Asn Asn Asn Gly Gly Cys Ser His Ser Cys Leu Gly
225                 230                 235                 240 
Ser Glu Lys Gly Tyr Gln Cys Glu Cys Pro Arg Gly Leu Val Leu Ser
                245                 250                 255     
Glu Asp Asn His Thr Cys Gln Val Pro Val Leu Cys Lys Ser Asn Ala
            260                 265                 270         
Ile Glu Val Asn Ile Pro Arg Glu Leu Val Gly Gly Leu Glu Leu Phe
        275                 280                 285             
Leu Thr Asn Thr Ser Cys Arg Gly Val Ser Asn Gly Thr His Val Asn
    290                 295                 300                 
Ile Leu Phe Ser Leu Lys Thr Cys Gly Thr Val Val Asp Val Val Asn
305                 310                 315                 320 
Asp Lys Ile Val Ala Ser Asn Leu Val Thr Gly Leu Pro Lys Gln Thr
                325                 330                 335     
Pro Gly Ser Ser Gly Asp Phe Ile Ile Arg Thr Ser Lys Leu Leu Ile
            340                 345                 350         
Pro Val Thr Cys Glu Phe Pro Arg Leu Tyr Thr Ile Ser Glu Gly Tyr
        355                 360                 365             
Val Pro Asn Leu Arg Asn Ser Pro Leu Glu Ile Met Ser Arg Asn His
    370                 375                 380                 
Gly Ile Phe Pro Phe Thr Leu Glu Ile Phe Lys Asp Asn Glu Phe Glu
385                 390                 395                 400 
Glu Pro Tyr Arg Glu Ala Leu Pro Thr Leu Lys Leu Arg Asp Ser Leu
                405                 410                 415     
Tyr Phe Gly Ile Glu Pro Val Val His Val Ser Gly Leu Glu Ser Leu
            420                 425                 430         
Val Glu Ser Cys Phe Ala Thr Pro Thr Ser Lys Ile Asp Glu Val Leu
        435                 440                 445             
Lys Tyr Tyr Leu Ile Arg Asp Gly Cys Val Ser Asp Asp Ser Val Lys
    450                 455                 460                 
Gln Tyr Thr Ser Arg Asp His Leu Ala Lys His Phe Gln Val Pro Val
465                 470                 475                 480 
Phe Lys Phe Val Gly Lys Asp His Lys Glu Val Phe Leu His Cys Arg
                485                 490                 495     
Val Leu Val Cys Gly Val Leu Asp Glu Arg Ser Arg Cys Ala Gln Gly
            500                 505                 510         
Cys His Arg Arg Met Arg Arg Gly Ala Gly Gly Glu Asp Ser Ala Gly
        515                 520                 525             
Leu Gln Gly Gln Thr Leu Thr Gly Gly Pro Ile Arg Ile Asp Trp Glu
    530                 535                 540                 
Asp
545 


<210> 9010
<211> 532
<212> PRT
<213> Homo sapiens

<400> 9010
Met Ala Pro Ser Phe Thr Ala Arg Ile Gln Leu Phe Leu Leu Arg Ala
 1               5                  10                  15      
Leu Gly Phe Leu Ile Gly Leu Val Gly Arg Ala Ala Leu Val Leu Gly
            20                  25                  30          
Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg Pro Val Thr Glu Pro Leu
        35                  40                  45              
Leu Leu Leu Ser Gly Met Gln Leu Ala Lys Leu Ile Arg Gln Arg Lys
    50                  55                  60                  
Val Lys Cys Ile Asp Val Val Gln Ala Tyr Ile Asn Arg Ile Lys Asp
65                  70                  75                  80  
Val Asn Pro Met Ile Asn Gly Ile Val Lys Tyr Arg Phe Glu Glu Ala
                85                  90                  95      
Met Arg Glu Ala His Ala Val Asp Gln Lys Leu Ala Glu Lys Gln Glu
            100                 105                 110         
Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro Phe Leu Gly Val Pro Leu
        115                 120                 125             
Thr Val Lys Glu Ala Phe Gln Leu Gln Gly Met Pro Asn Ser Ser Gly
    130                 135                 140                 
Leu Met Asn Arg Arg Asp Ala Ile Ala Lys Thr Asp Ala Thr Val Val
145                 150                 155                 160 
Ala Leu Leu Lys Gly Ala Gly Ala Ile Pro Leu Gly Ile Thr Asn Cys
                165                 170                 175     
Ser Glu Leu Cys Met Trp Tyr Glu Ser Ser Asn Lys Ile Tyr Gly Arg
            180                 185                 190         
Ser Asn Asn Pro Tyr Asp Leu Gln His Ile Val Gly Gly Ser Ser Gly
        195                 200                 205             
Gly Glu Gly Cys Thr Leu Ala Ala Ala Cys Ser Val Ile Gly Val Gly
    210                 215                 220                 
Ser Asp Ile Gly Gly Ser Ile Arg Met Pro Ala Phe Phe Asn Gly Ile
225                 230                 235                 240 
Phe Gly His Lys Pro Ser Pro Gly Val Val Pro Asn Lys Gly Gln Phe
                245                 250                 255     
Pro Leu Ala Val Gly Ala Gln Glu Leu Phe Leu Cys Thr Gly Pro Met
            260                 265                 270         
Cys Arg Tyr Ala Glu Asp Leu Ala Pro Met Leu Lys Val Met Ala Gly
        275                 280                 285             
Pro Gly Ile Lys Arg Leu Lys Leu Asp Thr Lys Val His Leu Lys Asp
    290                 295                 300                 
Leu Lys Phe Tyr Trp Met Glu His Asp Gly Gly Ser Phe Leu Met Ser
305                 310                 315                 320 
Lys Val Asp Gln Asp Leu Ile Met Thr Gln Lys Lys Val Val Val His
                325                 330                 335     
Leu Glu Thr Ile Leu Gly Ala Ser Val Gln His Val Lys Leu Lys Lys
            340                 345                 350         
Met Lys Tyr Ser Phe Gln Leu Trp Ile Ala Met Met Ser Ala Lys Gly
        355                 360                 365             
His Asp Gly Lys Glu Pro Val Lys Phe Val Asp Leu Leu Gly Asp His
    370                 375                 380                 
Gly Lys His Val Ser Pro Leu Trp Glu Leu Ile Lys Trp Cys Leu Gly
385                 390                 395                 400 
Leu Ser Val Tyr Thr Ile Pro Ser Ile Gly Leu Ala Leu Leu Glu Glu
                405                 410                 415     
Lys Leu Arg Tyr Ser Asn Glu Lys Tyr Gln Lys Phe Lys Ala Val Glu
            420                 425                 430         
Glu Ser Leu Arg Lys Glu Leu Val Asp Met Leu Gly Asp Asp Gly Val
        435                 440                 445             
Phe Leu Tyr Pro Ser His Pro Thr Val Ala Pro Lys His His Val Pro
    450                 455                 460                 
Leu Thr Arg Pro Phe Asn Phe Ala Tyr Thr Gly Val Phe Ser Ala Leu
465                 470                 475                 480 
Gly Leu Pro Val Thr Gln Cys Pro Leu Gly Leu Asn Ala Lys Gly Leu
                485                 490                 495     
Pro Leu Gly Ile Gln Val Val Ala Gly Pro Phe Asn Asp His Leu Thr
            500                 505                 510         
Leu Ala Val Ala Gln Tyr Leu Glu Lys Thr Phe Gly Gly Trp Val Cys
        515                 520                 525             
Pro Gly Lys Phe
    530         


<210> 9011
<211> 533
<212> PRT
<213> Homo sapiens

<400> 9011
Met Ile His Gly Arg Ser Val Leu His Ile Val Ala Ser Leu Ile Ile
 1               5                  10                  15      
Leu His Leu Ser Gly Ala Thr Lys Lys Gly Thr Glu Lys Gln Thr Thr
            20                  25                  30          
Ser Glu Thr Gln Lys Ser Val Gln Cys Gly Thr Trp Thr Lys His Ala
        35                  40                  45              
Glu Gly Gly Ile Phe Thr Ser Pro Asn Tyr Pro Ser Lys Tyr Pro Pro
    50                  55                  60                  
Asp Arg Glu Cys Ile Tyr Ile Ile Glu Ala Ala Pro Arg Gln Cys Ile
65                  70                  75                  80  
Glu Leu Tyr Phe Asp Glu Lys Tyr Ser Ile Glu Pro Ser Trp Glu Cys
                85                  90                  95      
Lys Phe Asp His Ile Glu Val Arg Asp Gly Pro Phe Gly Phe Ser Pro
            100                 105                 110         
Ile Ile Gly Arg Phe Cys Gly Gln Gln Asn Pro Pro Val Ile Lys Ser
        115                 120                 125             
Ser Gly Arg Phe Leu Trp Ile Lys Phe Phe Ala Asp Gly Glu Leu Glu
    130                 135                 140                 
Ser Met Gly Phe Ser Ala Arg Tyr Asn Phe Thr Pro Asp Pro Asp Phe
145                 150                 155                 160 
Lys Asp Leu Gly Ala Leu Lys Pro Leu Pro Ala Cys Glu Phe Glu Met
                165                 170                 175     
Gly Gly Ser Glu Gly Ile Val Glu Ser Ile Gln Ile Met Lys Glu Gly
            180                 185                 190         
Lys Ala Thr Ala Ser Glu Ala Val Asp Cys Lys Trp Tyr Ile Arg Ala
        195                 200                 205             
Pro Pro Arg Ser Lys Ile Tyr Leu Arg Phe Leu Asp Tyr Glu Met Gln
    210                 215                 220                 
Asn Ser Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr Asp Gly Ser
225                 230                 235                 240 
Ser Ser Val Glu Asp Leu Lys Ala Lys Phe Cys Ser Thr Val Ala Asn
                245                 250                 255     
Asp Val Met Leu Arg Thr Gly Leu Gly Val Ile Arg Met Trp Ala Asp
            260                 265                 270         
Glu Gly Ser Arg Asn Ser Arg Phe Gln Met Leu Phe Thr Ser Phe Gln
        275                 280                 285             
Glu Pro Pro Cys Glu Gly Asn Thr Phe Phe Cys His Ser Asn Met Cys
    290                 295                 300                 
Ile Asn Asn Thr Leu Val Cys Asn Gly Leu Gln Asn Cys Val Tyr Pro
305                 310                 315                 320 
Trp Asp Glu Asn His Cys Lys Glu Lys Arg Lys Thr Ser Leu Leu Asp
                325                 330                 335     
Gln Leu Thr Asn Thr Ser Gly Thr Val Ile Gly Val Thr Ser Cys Ile
            340                 345                 350         
Val Ile Ile Leu Ile Ile Ile Ser Val Ile Val Gln Ile Lys Gln Pro
        355                 360                 365             
Arg Lys Lys Tyr Val Gln Arg Lys Ser Asp Phe Asp Gln Thr Val Phe
    370                 375                 380                 
Gln Glu Val Phe Glu Pro Pro His Tyr Glu Leu Cys Thr Leu Arg Gly
385                 390                 395                 400 
Thr Gly Ala Thr Ala Asp Phe Ala Asp Val Ala Asp Asp Phe Glu Asn
                405                 410                 415     
Tyr His Lys Leu Arg Arg Ser Ser Ser Lys Cys Ile His Asp His His
            420                 425                 430         
Cys Gly Ser Gln Leu Ser Ser Thr Lys Gly Ser Arg Ser Asn Leu Ser
        435                 440                 445             
Thr Arg Asp Ala Ser Ile Leu Thr Glu Met Pro Thr Gln Pro Gly Lys
    450                 455                 460                 
Pro Leu Ile Pro Pro Met Asn Arg Arg Asn Ile Leu Val Met Lys His
465                 470                 475                 480 
Asn Tyr Ser Gln Asp Ala Ala Asp Ala Cys Asp Ile Asp Glu Ile Glu
                485                 490                 495     
Glu Val Pro Thr Thr Ser His Arg Leu Ser Arg His Asp Lys Ala Val
            500                 505                 510         
Gln Arg Phe Cys Leu Ile Gly Ser Leu Ser Lys His Glu Ser Glu Tyr
        515                 520                 525             
Asn Thr Thr Arg Val
    530             


<210> 9012
<211> 532
<212> PRT
<213> Homo sapiens

<400> 9012
Met Leu Ala Glu Pro Phe Pro Lys Val Val Ala Ser Leu Ile Ile Leu
 1               5                  10                  15      
His Leu Ser Gly Ala Thr Lys Lys Gly Thr Glu Lys Gln Thr Thr Ser
            20                  25                  30          
Glu Thr Gln Lys Ser Val Gln Cys Gly Thr Trp Thr Lys His Ala Glu
        35                  40                  45              
Gly Gly Ile Phe Thr Ser Pro Asn Tyr Pro Ser Lys Tyr Pro Pro Asp
    50                  55                  60                  
Arg Glu Cys Ile Tyr Ile Ile Glu Ala Ala Pro Arg Gln Cys Ile Glu
65                  70                  75                  80  
Leu Tyr Phe Asp Glu Lys Tyr Ser Ile Glu Pro Ser Trp Glu Cys Lys
                85                  90                  95      
Phe Asp His Ile Glu Val Arg Asp Gly Pro Phe Gly Phe Ser Pro Ile
            100                 105                 110         
Ile Gly Arg Phe Cys Gly Gln Gln Asn Pro Pro Val Ile Lys Ser Ser
        115                 120                 125             
Gly Arg Phe Leu Trp Ile Lys Phe Phe Ala Asp Gly Glu Leu Glu Ser
    130                 135                 140                 
Met Gly Phe Ser Ala Arg Tyr Asn Phe Thr Pro Asp Pro Asp Phe Lys
145                 150                 155                 160 
Asp Leu Gly Ala Leu Lys Pro Leu Pro Ala Cys Glu Phe Glu Met Gly
                165                 170                 175     
Gly Ser Glu Gly Ile Val Glu Ser Ile Gln Ile Met Lys Glu Gly Lys
            180                 185                 190         
Ala Thr Ala Ser Glu Ala Val Asp Cys Lys Trp Tyr Ile Arg Ala Pro
        195                 200                 205             
Pro Arg Ser Lys Ile Tyr Leu Arg Phe Leu Asp Tyr Glu Met Gln Asn
    210                 215                 220                 
Ser Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr Asp Gly Ser Ser
225                 230                 235                 240 
Ser Val Glu Asp Leu Lys Ala Lys Phe Cys Ser Thr Val Ala Asn Asp
                245                 250                 255     
Val Met Leu Arg Thr Gly Leu Gly Val Ile Arg Met Trp Ala Asp Glu
            260                 265                 270         
Gly Ser Arg Asn Ser Arg Phe Gln Met Leu Phe Thr Ser Phe Gln Glu
        275                 280                 285             
Pro Pro Cys Glu Gly Asn Thr Phe Phe Cys His Ser Asn Met Cys Ile
    290                 295                 300                 
Asn Asn Thr Leu Val Cys Asn Gly Leu Gln Asn Cys Val Tyr Pro Trp
305                 310                 315                 320 
Asp Glu Asn His Cys Lys Glu Lys Arg Lys Thr Ser Leu Leu Asp Gln
                325                 330                 335     
Leu Thr Asn Thr Ser Gly Thr Val Ile Gly Val Thr Ser Cys Ile Val
            340                 345                 350         
Ile Ile Leu Ile Ile Ile Ser Val Ile Val Gln Ile Lys Gln Pro Arg
        355                 360                 365             
Lys Lys Tyr Val Gln Arg Lys Ser Asp Phe Asp Gln Thr Val Phe Gln
    370                 375                 380                 
Glu Val Phe Glu Pro Pro His Tyr Glu Leu Cys Thr Leu Arg Gly Thr
385                 390                 395                 400 
Gly Ala Thr Ala Asp Phe Ala Asp Val Ala Asp Asp Phe Glu Asn Tyr
                405                 410                 415     
His Lys Leu Arg Arg Ser Ser Ser Lys Cys Ile His Asp His His Cys
            420                 425                 430         
Gly Ser Gln Leu Ser Ser Thr Lys Gly Ser Arg Ser Asn Leu Ser Thr
        435                 440                 445             
Arg Asp Ala Ser Ile Leu Thr Glu Met Pro Thr Gln Pro Gly Lys Pro
    450                 455                 460                 
Leu Ile Pro Pro Met Asn Arg Arg Asn Ile Leu Val Met Lys His Asn
465                 470                 475                 480 
Tyr Ser Gln Asp Ala Ala Asp Ala Cys Asp Ile Asp Glu Ile Glu Glu
                485                 490                 495     
Val Pro Thr Thr Ser His Arg Leu Ser Arg His Asp Lys Ala Val Gln
            500                 505                 510         
Arg Phe Cys Leu Ile Gly Ser Leu Ser Lys His Glu Ser Glu Tyr Asn
        515                 520                 525             
Thr Thr Arg Val
    530         


<210> 9013
<211> 378
<212> PRT
<213> Homo sapiens

<400> 9013
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30          
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45              
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60                  
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80  
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95      
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110         
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125             
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140                 
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160 
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175     
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190         
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205             
Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val
    210                 215                 220                 
Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro
225                 230                 235                 240 
Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp
                245                 250                 255     
Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn
            260                 265                 270         
Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro
        275                 280                 285             
Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu
    290                 295                 300                 
Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Asp Asp His Leu Gly
305                 310                 315                 320 
Gly Ile His Pro Arg Gly Arg Glu Arg Leu Pro Arg Arg Gly Leu Asp
                325                 330                 335     
Arg Glu Gly Asn Tyr Leu Arg Pro Arg Gly Cys Arg Asn Gly Met Asp
            340                 345                 350         
Ile Ser Ala Ser Ala Thr Arg Gly Asn Cys Phe Leu Asp Asp Ala Val
        355                 360                 365             
Asn Leu Tyr Ile Ile Phe Tyr Val Phe Ile
    370                 375             


<210> 9014
<211> 410
<212> PRT
<213> Homo sapiens

<400> 9014
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30          
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45              
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60                  
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80  
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95      
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110         
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125             
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140                 
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160 
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175     
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190         
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205             
Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val
    210                 215                 220                 
Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro
225                 230                 235                 240 
Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp
                245                 250                 255     
Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn
            260                 265                 270         
Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro
        275                 280                 285             
Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu
    290                 295                 300                 
Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly
305                 310                 315                 320 
Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu
                325                 330                 335     
Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile
            340                 345                 350         
Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp
        355                 360                 365             
Asn His Glu Val Glu Asp Glu Met Gly Pro Gln Arg His His Arg Cys
    370                 375                 380                 
Gly Trp Asn Leu Tyr Pro Thr Pro Gly Pro Ser Pro Gly Ser Gly Ser
385                 390                 395                 400 
Ser Pro Arg Leu Gly Ser Glu Ser Ser Leu
                405                 410 


<210> 9015
<211> 333
<212> PRT
<213> Homo sapiens

<400> 9015
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30          
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45              
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60                  
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80  
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95      
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110         
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125             
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140                 
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160 
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175     
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190         
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205             
Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val
    210                 215                 220                 
Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro
225                 230                 235                 240 
Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp
                245                 250                 255     
Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn
            260                 265                 270         
Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro
        275                 280                 285             
Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu
    290                 295                 300                 
Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Leu Gly Tyr
305                 310                 315                 320 
Ser Gly Cys Ser Arg Gln Phe His Arg Ser Lys Thr Asn
                325                 330             


<210> 9016
<211> 233
<212> PRT
<213> Homo sapiens

<400> 9016
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30          
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45              
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60                  
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80  
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95      
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110         
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125             
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140                 
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160 
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175     
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190         
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205             
Leu Leu Asp Thr Lys Lys Ile Gly Ser Leu Gly Tyr Ser Gly Cys Ser
    210                 215                 220                 
Arg Gln Phe His Arg Ser Lys Thr Asn
225                 230             


<210> 9017
<211> 400
<212> PRT
<213> Homo sapiens

<400> 9017
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30          
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45              
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60                  
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80  
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95      
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110         
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125             
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140                 
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160 
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175     
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190         
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205             
Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val
    210                 215                 220                 
Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro
225                 230                 235                 240 
Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp
                245                 250                 255     
Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn
            260                 265                 270         
Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro
        275                 280                 285             
Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu
    290                 295                 300                 
Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly
305                 310                 315                 320 
Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu
                325                 330                 335     
Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile
            340                 345                 350         
Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp
        355                 360                 365             
Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu
    370                 375                 380                 
Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr
385                 390                 395                 400 


<210> 9018
<211> 286
<212> PRT
<213> Homo sapiens

<400> 9018
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30          
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45              
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60                  
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80  
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95      
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110         
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125             
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140                 
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160 
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175     
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190         
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205             
Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val
    210                 215                 220                 
Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro
225                 230                 235                 240 
Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp
                245                 250                 255     
Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Val Val
            260                 265                 270         
Leu Thr Thr Gly Thr Ser Ala Leu Cys Thr Phe Met Cys Ser
        275                 280                 285     


<210> 9019
<211> 529
<212> PRT
<213> Homo sapiens

<400> 9019
Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser
 1               5                  10                  15      
Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu
            20                  25                  30          
Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln
        35                  40                  45              
Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro
    50                  55                  60                  
Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp
65                  70                  75                  80  
Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met
                85                  90                  95      
Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys
            100                 105                 110         
Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala
        115                 120                 125             
Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr
    130                 135                 140                 
Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys
145                 150                 155                 160 
Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe
                165                 170                 175     
Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser
            180                 185                 190         
Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu
        195                 200                 205             
Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys
    210                 215                 220                 
Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp
225                 230                 235                 240 
Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His
                245                 250                 255     
Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp
            260                 265                 270         
Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu
        275                 280                 285             
Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His
    290                 295                 300                 
Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe
305                 310                 315                 320 
Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala
                325                 330                 335     
Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr
            340                 345                 350         
Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile
        355                 360                 365             
Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro
    370                 375                 380                 
Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp
385                 390                 395                 400 
Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala
                405                 410                 415     
Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu
            420                 425                 430         
Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp
        435                 440                 445             
Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile
    450                 455                 460                 
Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly
465                 470                 475                 480 
Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val
                485                 490                 495     
Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln
            500                 505                 510         
Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His
        515                 520                 525             
Leu
    


<210> 9020
<211> 502
<212> PRT
<213> Homo sapiens

<400> 9020
Met Phe Gly Thr Leu Leu Leu Tyr Cys Phe Phe Leu Ala Thr Val Pro
 1               5                  10                  15      
Ala Leu Ala Glu Thr Gly Gly Glu Arg Gln Leu Ser Pro Glu Lys Ser
            20                  25                  30          
Glu Ile Trp Gly Pro Gly Leu Lys Ala Asp Val Val Leu Pro Ala Arg
        35                  40                  45              
Tyr Phe Tyr Ile Gln Ala Val Asp Thr Ser Gly Asn Lys Phe Thr Ser
    50                  55                  60                  
Ser Pro Gly Glu Lys Val Phe Gln Val Lys Val Ser Ala Pro Glu Glu
65                  70                  75                  80  
Gln Phe Thr Arg Val Gly Val Gln Val Leu Asp Arg Lys Asp Gly Ser
                85                  90                  95      
Phe Ile Val Arg Tyr Arg Met Tyr Ala Ser Tyr Lys Asn Leu Lys Val
            100                 105                 110         
Glu Val Lys Phe Gln Gly Gln His Val Ala Lys Ser Pro Tyr Ile Leu
        115                 120                 125             
Lys Gly Pro Val Tyr His Glu Asn Cys Asp Cys Pro Leu Gln Asp Ser
    130                 135                 140                 
Ala Ala Trp Leu Arg Glu Met Asn Cys Pro Glu Thr Ile Ala Gln Ile
145                 150                 155                 160 
Gln Arg Asp Leu Ala His Phe Pro Ala Val Asp Pro Glu Lys Ile Ala
                165                 170                 175     
Val Glu Ile Pro Lys Arg Phe Gly Gln Arg Gln Ser Leu Cys His Tyr
            180                 185                 190         
Thr Leu Lys Asp Asn Lys Val Tyr Ile Lys Thr His Gly Glu His Val
        195                 200                 205             
Gly Phe Arg Ile Phe Met Asp Ala Ile Leu Leu Ser Leu Thr Arg Lys
    210                 215                 220                 
Val Lys Met Pro Asp Val Glu Leu Phe Val Asn Leu Gly Asp Trp Pro
225                 230                 235                 240 
Leu Glu Lys Lys Lys Ser Asn Ser Asn Ile His Pro Ile Phe Ser Trp
                245                 250                 255     
Cys Gly Ser Thr Asp Ser Lys Asp Ile Val Met Pro Thr Tyr Asp Leu
            260                 265                 270         
Thr Asp Ser Val Leu Glu Thr Met Gly Arg Val Ser Leu Asp Met Met
        275                 280                 285             
Ser Val Gln Ala Asn Thr Gly Pro Pro Trp Glu Ser Lys Asn Ser Thr
    290                 295                 300                 
Ala Val Trp Arg Gly Arg Asp Ser Arg Lys Glu Arg Leu Glu Leu Val
305                 310                 315                 320 
Lys Leu Ser Arg Lys His Pro Glu Leu Ile Asp Ala Ala Phe Thr Asn
                325                 330                 335     
Phe Phe Phe Phe Lys His Asp Glu Asn Leu Tyr Gly Pro Ile Val Lys
            340                 345                 350         
His Ile Ser Phe Phe Asp Phe Phe Lys His Lys Tyr Gln Ile Asn Ile
        355                 360                 365             
Asp Gly Thr Val Ala Ala Tyr Arg Leu Pro Tyr Leu Leu Val Gly Asp
    370                 375                 380                 
Ser Val Val Leu Lys Gln Asp Ser Ile Tyr Tyr Glu His Phe Tyr Asn
385                 390                 395                 400 
Glu Leu Gln Pro Trp Lys His Tyr Ile Pro Val Lys Ser Asn Leu Ser
                405                 410                 415     
Asp Leu Leu Glu Lys Leu Lys Trp Ala Lys Asp His Asp Glu Glu Ala
            420                 425                 430         
Lys Lys Ile Ala Lys Ala Gly Gln Glu Phe Ala Arg Asn Asn Leu Met
        435                 440                 445             
Gly Asp Asp Ile Phe Cys Tyr Tyr Phe Lys Leu Phe Gln Glu Tyr Ala
    450                 455                 460                 
Asn Leu Gln Val Ser Glu Pro Gln Ile Arg Glu Gly Met Lys Arg Val
465                 470                 475                 480 
Glu Pro Gln Thr Glu Asp Asp Leu Phe Pro Cys Thr Cys His Arg Lys
                485                 490                 495     
Lys Thr Lys Asp Glu Leu
            500         


<210> 9021
<211> 532
<212> PRT
<213> Homo sapiens

<400> 9021
Met Pro Leu Phe Leu Ile Leu Cys Leu Leu Gln Gly Ser Ser Phe Ala
 1               5                  10                  15      
Leu Pro Gln Lys Arg Pro His Pro Arg Trp Leu Trp Glu Gly Ser Leu
            20                  25                  30          
Pro Ser Arg Thr His Leu Arg Ala Met Gly Thr Leu Arg Pro Ser Ser
        35                  40                  45              
Pro Leu Cys Trp Arg Glu Glu Ser Ser Phe Ala Ala Pro Asn Ser Leu
    50                  55                  60                  
Lys Gly Ser Arg Leu Val Ser Gly Glu Pro Gly Gly Ala Val Thr Ile
65                  70                  75                  80  
Gln Cys His Tyr Ala Pro Ser Ser Val Asn Arg His Gln Arg Lys Tyr
                85                  90                  95      
Trp Cys Arg Leu Gly Pro Pro Arg Trp Ile Cys Gln Thr Ile Val Ser
            100                 105                 110         
Thr Asn Gln Tyr Thr His His Arg Tyr Arg Asp Arg Val Ala Leu Thr
        115                 120                 125             
Asp Phe Pro Gln Arg Gly Leu Phe Val Val Arg Leu Ser Gln Leu Ser
    130                 135                 140                 
Pro Asp Asp Ile Gly Cys Tyr Leu Cys Gly Ile Gly Ser Glu Asn Asn
145                 150                 155                 160 
Met Leu Phe Leu Ser Met Asn Leu Thr Ile Ser Ala Gly Pro Ala Ser
                165                 170                 175     
Thr Leu Pro Thr Ala Thr Pro Ala Ala Gly Glu Leu Thr Met Arg Ser
            180                 185                 190         
Tyr Gly Thr Ala Ser Pro Val Ala Asn Arg Trp Thr Pro Gly Thr Thr
        195                 200                 205             
Gln Thr Leu Gly Gln Gly Thr Ala Trp Asp Thr Val Ala Ser Thr Pro
    210                 215                 220                 
Gly Thr Ser Lys Thr Thr Ala Ser Ala Glu Gly Arg Arg Thr Pro Gly
225                 230                 235                 240 
Ala Thr Arg Pro Ala Ala Pro Gly Thr Gly Ser Trp Ala Glu Gly Ser
                245                 250                 255     
Val Lys Ala Pro Ala Pro Ile Pro Glu Ser Pro Pro Ser Lys Ser Arg
            260                 265                 270         
Ser Met Ser Asn Thr Thr Glu Gly Val Trp Glu Gly Thr Arg Ser Ser
        275                 280                 285             
Val Thr Asn Arg Ala Arg Ala Ser Lys Asp Arg Arg Glu Met Thr Thr
    290                 295                 300                 
Thr Lys Ala Asp Arg Pro Arg Glu Asp Ile Glu Gly Val Arg Ile Ala
305                 310                 315                 320 
Leu Asp Ala Ala Lys Lys Val Leu Gly Thr Ile Gly Pro Pro Ala Leu
                325                 330                 335     
Val Ser Glu Thr Leu Ala Trp Glu Ile Leu Pro Gln Ala Thr Pro Val
            340                 345                 350         
Ser Lys Gln Gln Ser Gln Gly Ser Ile Gly Glu Thr Thr Pro Ala Ala
        355                 360                 365             
Gly Met Trp Thr Leu Gly Thr Pro Ala Ala Asp Val Trp Ile Leu Gly
    370                 375                 380                 
Thr Pro Ala Ala Asp Val Trp Thr Ser Met Glu Ala Ala Ser Gly Glu
385                 390                 395                 400 
Gly Ser Ala Ala Gly Asp Leu Asp Ala Ala Thr Gly Asp Arg Gly Pro
                405                 410                 415     
Gln Ala Thr Leu Ser Gln Thr Pro Ala Val Gly Pro Trp Gly Pro Pro
            420                 425                 430         
Gly Lys Glu Ser Ser Val Lys Arg Thr Phe Pro Glu Asp Glu Ser Ser
        435                 440                 445             
Ser Arg Thr Leu Ala Pro Val Ser Thr Met Leu Ala Leu Phe Met Leu
    450                 455                 460                 
Met Ala Leu Val Leu Leu Gln Arg Lys Leu Trp Arg Arg Arg Thr Ser
465                 470                 475                 480 
Gln Glu Ala Glu Arg Val Thr Leu Ile Gln Met Thr His Phe Leu Glu
                485                 490                 495     
Val Asn Pro Gln Ala Asp Gln Leu Pro His Val Glu Arg Lys Met Leu
            500                 505                 510         
Gln Asp Asp Ser Leu Pro Ala Gly Ala Ser Leu Thr Ala Pro Glu Arg
        515                 520                 525             
Asn Pro Gly Pro
    530         


<210> 9022
<211> 544
<212> PRT
<213> Homo sapiens

<400> 9022
Met Asp Gly Glu Ala Thr Val Lys Pro Gly Glu Gln Lys Val Pro Leu
 1               5                  10                  15      
Trp Thr His Gly Trp Pro Pro Asp Asp Pro Ser Pro Ser Phe Ala Ala
            20                  25                  30          
Gly Ser Ser Phe Ala Leu Pro Gln Lys Arg Pro His Pro Arg Trp Leu
        35                  40                  45              
Trp Glu Gly Ser Leu Pro Ser Arg Thr His Leu Arg Ala Met Gly Thr
    50                  55                  60                  
Leu Arg Pro Ser Ser Pro Leu Cys Trp Arg Glu Glu Ser Ser Phe Ala
65                  70                  75                  80  
Ala Pro Asn Ser Leu Lys Gly Ser Arg Leu Val Ser Gly Glu Pro Gly
                85                  90                  95      
Gly Ala Val Thr Ile Gln Cys His Tyr Ala Pro Ser Ser Val Asn Arg
            100                 105                 110         
His Gln Arg Lys Tyr Trp Cys Arg Leu Gly Pro Pro Arg Trp Ile Cys
        115                 120                 125             
Gln Thr Ile Val Ser Thr Asn Gln Tyr Thr His His Arg Tyr Arg Asp
    130                 135                 140                 
Arg Val Ala Leu Thr Asp Phe Pro Gln Arg Gly Leu Phe Val Val Arg
145                 150                 155                 160 
Leu Ser Gln Leu Ser Pro Asp Asp Ile Gly Cys Tyr Leu Cys Gly Ile
                165                 170                 175     
Gly Ser Glu Asn Asn Met Leu Phe Leu Ser Met Asn Leu Thr Ile Ser
            180                 185                 190         
Ala Gly Pro Ala Ser Thr Leu Pro Thr Ala Thr Pro Ala Ala Gly Glu
        195                 200                 205             
Leu Thr Met Arg Ser Tyr Gly Thr Ala Ser Pro Val Ala Asn Arg Trp
    210                 215                 220                 
Thr Pro Gly Thr Thr Gln Thr Leu Gly Gln Gly Thr Ala Trp Asp Thr
225                 230                 235                 240 
Val Ala Ser Thr Pro Gly Thr Ser Lys Thr Thr Ala Ser Ala Glu Gly
                245                 250                 255     
Arg Arg Thr Pro Gly Ala Thr Arg Pro Ala Ala Pro Gly Thr Gly Ser
            260                 265                 270         
Trp Ala Glu Gly Ser Val Lys Ala Pro Ala Pro Ile Pro Glu Ser Pro
        275                 280                 285             
Pro Ser Lys Ser Arg Ser Met Ser Asn Thr Thr Glu Gly Val Trp Glu
    290                 295                 300                 
Gly Thr Arg Ser Ser Val Thr Asn Arg Ala Arg Ala Ser Lys Asp Arg
305                 310                 315                 320 
Arg Glu Met Thr Thr Thr Lys Ala Asp Arg Pro Arg Glu Asp Ile Glu
                325                 330                 335     
Gly Val Arg Ile Ala Leu Asp Ala Ala Lys Lys Val Leu Gly Thr Ile
            340                 345                 350         
Gly Pro Pro Ala Leu Val Ser Glu Thr Leu Ala Trp Glu Ile Leu Pro
        355                 360                 365             
Gln Ala Thr Pro Val Ser Lys Gln Gln Ser Gln Gly Ser Ile Gly Glu
    370                 375                 380                 
Thr Thr Pro Ala Ala Gly Met Trp Thr Leu Gly Thr Pro Ala Ala Asp
385                 390                 395                 400 
Val Trp Ile Leu Gly Thr Pro Ala Ala Asp Val Trp Thr Ser Met Glu
                405                 410                 415     
Ala Ala Ser Gly Glu Gly Ser Ala Ala Gly Asp Leu Asp Ala Ala Thr
            420                 425                 430         
Gly Asp Arg Gly Pro Gln Ala Thr Leu Ser Gln Thr Pro Ala Val Gly
        435                 440                 445             
Pro Trp Gly Pro Pro Gly Lys Glu Ser Ser Val Lys Arg Ala Thr Cys
    450                 455                 460                 
Pro Gly Leu Ser Thr Leu Lys Glu Ile Lys Val Ser Ala Val Leu Thr
465                 470                 475                 480 
Gln Asn Pro His Ser Leu Leu Cys Val Ser Ala Ala Gln Glu Ala Glu
                485                 490                 495     
Arg Val Thr Leu Ile Gln Met Thr His Phe Leu Glu Val Asn Pro Gln
            500                 505                 510         
Ala Asp Gln Leu Pro His Val Glu Arg Lys Met Leu Gln Asp Asp Ser
        515                 520                 525             
Leu Pro Ala Gly Ala Ser Leu Thr Ala Pro Glu Arg Asn Pro Gly Pro
    530                 535                 540                 


<210> 9023
<211> 530
<212> PRT
<213> Homo sapiens

<400> 9023
Met Ser Leu Lys Trp Met Ser Val Phe Leu Leu Met Gln Leu Ser Cys
 1               5                  10                  15      
Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu
            20                  25                  30          
Tyr Ser His Trp Ile Asn Met Lys Thr Ile Leu Glu Glu Leu Val Gln
        35                  40                  45              
Arg Gly His Glu Val Ile Val Leu Thr Ser Ser Ala Ser Ile Leu Val
    50                  55                  60                  
Asn Ala Ser Lys Ser Ser Ala Ile Lys Leu Glu Val Tyr Pro Thr Ser
65                  70                  75                  80  
Leu Thr Lys Asn Asp Leu Glu Asp Phe Phe Met Lys Met Phe Asp Arg
                85                  90                  95      
Trp Thr Tyr Ser Ile Ser Lys Asn Thr Phe Trp Ser Tyr Phe Ser Gln
            100                 105                 110         
Leu Gln Glu Leu Cys Trp Glu Tyr Ser Asp Tyr Asn Ile Lys Leu Cys
        115                 120                 125             
Glu Asp Ala Val Leu Asn Lys Lys Leu Met Arg Lys Leu Gln Glu Ser
    130                 135                 140                 
Lys Phe Asp Val Leu Leu Ala Asp Ala Val Asn Pro Cys Gly Glu Leu
145                 150                 155                 160 
Leu Ala Glu Leu Leu Asn Ile Pro Phe Leu Tyr Ser Leu Arg Phe Ser
                165                 170                 175     
Val Gly Tyr Thr Val Glu Lys Asn Gly Gly Gly Phe Leu Phe Pro Pro
            180                 185                 190         
Ser Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln Met Ile Phe
        195                 200                 205             
Met Glu Arg Ile Lys Asn Met Ile Tyr Met Leu Tyr Phe Asp Phe Trp
    210                 215                 220                 
Phe Gln Ala Tyr Asp Leu Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val
225                 230                 235                 240 
Leu Gly Arg Pro Thr Thr Leu Phe Glu Thr Met Gly Lys Ala Glu Met
                245                 250                 255     
Trp Leu Ile Arg Thr Tyr Trp Asp Phe Glu Phe Pro Arg Pro Phe Leu
            260                 265                 270         
Pro Asn Val Asp Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro
        275                 280                 285             
Leu Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly
    290                 295                 300                 
Ile Val Val Phe Ser Leu Gly Ser Met Ile Ser Asn Met Ser Glu Glu
305                 310                 315                 320 
Ser Ala Asn Met Ile Ala Ser Ala Leu Ala Gln Ile Pro Gln Lys Val
                325                 330                 335     
Leu Trp Arg Phe Asp Gly Lys Lys Pro Asn Thr Leu Gly Ser Asn Thr
            340                 345                 350         
Arg Leu Tyr Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Lys
        355                 360                 365             
Thr Lys Ala Phe Ile Thr His Gly Gly Thr Asn Gly Ile Tyr Glu Ala
    370                 375                 380                 
Ile Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe Ala Asp Gln
385                 390                 395                 400 
His Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Leu Ser Val
                405                 410                 415     
Asp Ile Arg Thr Met Ser Ser Arg Asp Leu Leu Asn Ala Leu Lys Ser
            420                 425                 430         
Val Ile Asn Asp Pro Ile Tyr Lys Glu Asn Ile Met Lys Leu Ser Arg
        435                 440                 445             
Ile His His Asp Gln Pro Val Lys Pro Leu Asp Arg Ala Val Phe Trp
    450                 455                 460                 
Ile Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala
465                 470                 475                 480 
Ala His Asn Leu Thr Trp Ile Gln Tyr His Ser Leu Asp Val Ile Ala
                485                 490                 495     
Phe Leu Leu Ala Cys Val Ala Thr Met Ile Phe Met Ile Thr Lys Cys
            500                 505                 510         
Cys Leu Phe Cys Phe Arg Lys Leu Ala Lys Thr Gly Lys Lys Lys Lys
        515                 520                 525             
Arg Asp
    530 


<210> 9024
<211> 530
<212> PRT
<213> Homo sapiens

<400> 9024
Met Ser Leu Lys Trp Thr Ser Val Phe Leu Leu Ile Gln Leu Ser Cys
 1               5                  10                  15      
Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu
            20                  25                  30          
Tyr Ser His Trp Ile Asn Met Lys Thr Ile Leu Glu Glu Leu Val Gln
        35                  40                  45              
Arg Gly His Glu Val Thr Val Leu Thr Ser Ser Ala Ser Thr Leu Val
    50                  55                  60                  
Asn Ala Ser Lys Ser Ser Ala Ile Lys Leu Glu Val Tyr Pro Thr Ser
65                  70                  75                  80  
Leu Thr Lys Asn Asp Leu Glu Asp Ser Leu Leu Lys Ile Leu Asp Arg
                85                  90                  95      
Trp Ile Tyr Gly Val Ser Lys Asn Thr Phe Trp Ser Tyr Phe Ser Gln
            100                 105                 110         
Leu Gln Glu Leu Cys Trp Glu Tyr Tyr Asp Tyr Ser Asn Lys Leu Cys
        115                 120                 125             
Lys Asp Ala Val Leu Asn Lys Lys Leu Met Met Lys Leu Gln Glu Ser
    130                 135                 140                 
Lys Phe Asp Val Ile Leu Ala Asp Ala Leu Asn Pro Cys Gly Glu Leu
145                 150                 155                 160 
Leu Ala Glu Leu Phe Asn Ile Pro Phe Leu Tyr Ser Leu Arg Phe Ser
                165                 170                 175     
Val Gly Tyr Thr Phe Glu Lys Asn Gly Gly Gly Phe Leu Phe Pro Pro
            180                 185                 190         
Ser Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln Met Ile Phe
        195                 200                 205             
Met Glu Arg Ile Lys Asn Met Ile His Met Leu Tyr Phe Asp Phe Trp
    210                 215                 220                 
Phe Gln Ile Tyr Asp Leu Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val
225                 230                 235                 240 
Leu Gly Arg Pro Thr Thr Leu Phe Glu Thr Met Gly Lys Ala Glu Met
                245                 250                 255     
Trp Leu Ile Arg Thr Tyr Trp Asp Phe Glu Phe Pro Arg Pro Phe Leu
            260                 265                 270         
Pro Asn Val Asp Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro
        275                 280                 285             
Leu Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly
    290                 295                 300                 
Ile Val Val Phe Ser Leu Gly Ser Met Ile Ser Asn Met Ser Glu Glu
305                 310                 315                 320 
Ser Ala Asn Met Ile Ala Ser Ala Leu Ala Gln Ile Pro Gln Lys Val
                325                 330                 335     
Leu Trp Arg Phe Asp Gly Lys Lys Pro Asn Thr Leu Gly Ser Asn Thr
            340                 345                 350         
Arg Leu Tyr Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Lys
        355                 360                 365             
Thr Lys Ala Phe Ile Thr His Gly Gly Thr Asn Gly Ile Tyr Glu Ala
    370                 375                 380                 
Ile Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe Ala Asp Gln
385                 390                 395                 400 
His Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Leu Ser Val
                405                 410                 415     
Asp Ile Arg Thr Met Ser Ser Arg Asp Leu Leu Asn Ala Leu Lys Ser
            420                 425                 430         
Val Ile Asn Asp Pro Val Tyr Lys Glu Asn Val Met Lys Leu Ser Arg
        435                 440                 445             
Ile His His Asp Gln Pro Met Lys Pro Leu Asp Arg Ala Val Phe Trp
    450                 455                 460                 
Ile Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu Arg Val Ala
465                 470                 475                 480 
Ala His Asn Leu Thr Trp Ile Gln Tyr His Ser Leu Asp Val Ile Ala
                485                 490                 495     
Phe Leu Leu Ala Cys Val Ala Thr Val Ile Phe Ile Ile Thr Lys Phe
            500                 505                 510         
Cys Leu Phe Cys Phe Arg Lys Leu Ala Lys Thr Gly Lys Lys Lys Lys
        515                 520                 525             
Arg Asp
    530 


<210> 9025
<211> 976
<212> PRT
<213> Homo sapiens

<400> 9025
Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln Val Leu Thr Gln
 1               5                  10                  15      
Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala Glu Glu Gln Leu
            20                  25                  30          
Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val Leu Leu Asn Ile
        35                  40                  45              
Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp Leu Ala Val Leu
    50                  55                  60                  
Tyr Phe Lys His Gly Ile Asp Arg Tyr Trp Arg Arg Val Ala Pro His
65                  70                  75                  80  
Ala Leu Ser Glu Glu Glu Lys Thr Thr Leu Arg Ala Gly Leu Ile Thr
                85                  90                  95      
Asn Phe Asn Glu Pro Ile Asn Gln Ile Ala Thr Gln Ile Ala Val Leu
            100                 105                 110         
Ile Ala Lys Val Ala Arg Leu Asp Cys Pro Arg Gln Trp Pro Glu Leu
        115                 120                 125             
Ile Pro Thr Leu Ile Glu Ser Val Lys Val Gln Asp Asp Leu Arg Gln
    130                 135                 140                 
His Arg Ala Leu Leu Thr Phe Tyr His Val Thr Lys Thr Leu Ala Ser
145                 150                 155                 160 
Lys Arg Leu Ala Ala Asp Arg Lys Leu Phe Tyr Asp Leu Ala Ser Gly
                165                 170                 175     
Ile Tyr Asn Phe Ala Cys Ser Leu Trp Asn His His Thr Asp Thr Phe
            180                 185                 190         
Leu Gln Glu Val Ser Ser Gly Asn Glu Ala Ala Ile Leu Ser Ser Leu
        195                 200                 205             
Glu Arg Thr Leu Leu Ser Leu Lys Val Leu Arg Lys Leu Thr Val Asn
    210                 215                 220                 
Gly Phe Val Glu Pro His Lys Asn Met Glu Val Met Gly Phe Leu His
225                 230                 235                 240 
Gly Ile Phe Glu Arg Leu Lys Gln Phe Leu Glu Cys Ser Arg Ser Ile
                245                 250                 255     
Gly Thr Asp Asn Val Cys Arg Asp Arg Leu Glu Lys Thr Ile Ile Leu
            260                 265                 270         
Phe Thr Lys Val Leu Leu Asp Phe Leu Asp Gln His Pro Phe Ser Phe
        275                 280                 285             
Thr Pro Leu Ile Gln Arg Ser Leu Glu Phe Ser Val Ser Tyr Val Phe
    290                 295                 300                 
Thr Glu Val Gly Glu Gly Val Thr Phe Glu Arg Phe Ile Val Gln Cys
305                 310                 315                 320 
Met Asn Leu Ile Lys Met Ile Val Lys Asn Tyr Ala Tyr Lys Pro Ser
                325                 330                 335     
Lys Asn Phe Glu Asp Ser Ser Pro Glu Thr Leu Glu Ala His Lys Ile
            340                 345                 350         
Lys Met Ala Phe Phe Thr Tyr Pro Thr Leu Thr Glu Ile Cys Arg Arg
        355                 360                 365             
Leu Val Ser His Tyr Phe Leu Leu Thr Glu Glu Glu Leu Thr Met Trp
    370                 375                 380                 
Glu Glu Asp Pro Glu Gly Phe Thr Val Glu Glu Thr Gly Gly Asp Ser
385                 390                 395                 400 
Trp Lys Tyr Ser Leu Arg Pro Cys Thr Glu Val Leu Phe Ile Asp Ile
                405                 410                 415     
Phe His Glu Tyr Asn Gln Thr Leu Thr Pro Val Leu Leu Glu Met Met
            420                 425                 430         
Gln Thr Leu Gln Gly Pro Thr Asn Val Glu Asp Met Asn Ala Leu Leu
        435                 440                 445             
Ile Lys Asp Ala Val Tyr Asn Ala Val Gly Leu Ala Ala Tyr Glu Leu
    450                 455                 460                 
Phe Asp Ser Val Asp Phe Asp Gln Trp Phe Lys Asn Gln Leu Leu Pro
465                 470                 475                 480 
Glu Leu Gln Val Ile His Asn Arg Gln Tyr Lys Pro Leu Arg Arg Arg
                485                 490                 495     
Val Ile Trp Leu Ile Gly Gln Trp Ile Ser Val Lys Phe Lys Ser Asp
            500                 505                 510         
Leu Arg Pro Met Leu Tyr Glu Ala Ile Cys Asn Leu Leu Gln Asp Gln
        515                 520                 525             
Asp Leu Val Val Cys Phe Leu Ile Phe Leu Asn Cys Ser Ser Pro Val
    530                 535                 540                 
Asp Asp Phe Glu Phe Arg Thr Asp Gln Phe Leu Pro Tyr Leu Glu Thr
545                 550                 555                 560 
Met Phe Thr Leu Leu Phe Gln Leu Leu Gln Gln Val Thr Glu Cys Asp
                565                 570                 575     
Thr Lys Met His Val Leu His Val Leu Ser Cys Val Ile Glu Arg Val
            580                 585                 590         
Asn Met Gln Ile Arg Pro Tyr Val Gly Cys Leu Val Gln Tyr Leu Pro
        595                 600                 605             
Leu Leu Trp Lys Gln Ser Glu Glu His Asn Met Leu Arg Cys Ala Ile
    610                 615                 620                 
Leu Thr Thr Leu Ile His Leu Val Gln Gly Leu Gly Ala Asp Ser Lys
625                 630                 635                 640 
Asn Leu Tyr Pro Phe Leu Leu Pro Val Ile Gln Leu Ser Thr Asp Val
                645                 650                 655     
Ser Gln Pro Pro His Val Tyr Leu Leu Glu Asp Gly Leu Glu Leu Trp
            660                 665                 670         
Leu Val Thr Leu Glu Asn Ser Pro Cys Ile Thr Pro Glu Leu Leu Arg
        675                 680                 685             
Ile Phe Gln Asn Met Ser Pro Leu Leu Glu Leu Ser Ser Glu Asn Leu
    690                 695                 700                 
Arg Thr Cys Phe Lys Ile Ile Asn Gly Tyr Ile Phe Leu Ser Ser Thr
705                 710                 715                 720 
Glu Phe Leu Gln Thr Tyr Ala Val Gly Leu Cys Gln Ser Phe Cys Glu
                725                 730                 735     
Leu Leu Lys Glu Ile Thr Thr Glu Gly Gln Val Gln Val Leu Lys Val
            740                 745                 750         
Val Glu Asn Ala Leu Lys Val Asn Pro Ile Leu Gly Pro Gln Met Phe
        755                 760                 765             
Gln Pro Ile Leu Pro Tyr Val Phe Lys Gly Ile Ile Glu Gly Glu Arg
    770                 775                 780                 
Tyr Pro Val Val Met Ser Thr Tyr Leu Gly Val Met Gly Arg Val Leu
785                 790                 795                 800 
Leu Gln Asn Thr Ser Phe Phe Ser Ser Leu Leu Asn Glu Met Ala His
                805                 810                 815     
Lys Phe Asn Gln Glu Met Asp Gln Leu Leu Gly Asn Met Ile Glu Met
            820                 825                 830         
Trp Val Asp Arg Met Asp Asn Ile Thr Gln Pro Glu Arg Arg Lys Leu
        835                 840                 845             
Ser Ala Leu Ala Leu Leu Ser Leu Leu Pro Ser Asp Asn Ser Val Ile
    850                 855                 860                 
Gln Asp Lys Phe Cys Gly Ile Ile Asn Ile Ser Val Glu Gly Leu His
865                 870                 875                 880 
Asp Val Met Thr Glu Asp Pro Glu Thr Gly Thr Tyr Lys Asp Cys Met
                885                 890                 895     
Leu Met Ser His Leu Glu Glu Pro Lys Val Thr Glu Asp Glu Glu Pro
            900                 905                 910         
Pro Thr Glu Gln Asp Lys Arg Lys Lys Met Leu Ala Leu Lys Asp Pro
        915                 920                 925             
Val His Thr Val Ser Leu Gln Gln Phe Ile Tyr Glu Lys Leu Lys Ala
    930                 935                 940                 
Gln Gln Glu Met Leu Gly Glu Gln Gly Phe Gln Ser Leu Met Glu Thr
945                 950                 955                 960 
Val Asp Thr Glu Ile Val Thr Gln Leu Gln Glu Phe Leu Gln Gly Phe
                965                 970                 975     


<210> 9026
<211> 1342
<212> PRT
<213> Homo sapiens

<400> 9026
Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu
 1               5                  10                  15      
Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr
            20                  25                  30          
Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr
        35                  40                  45              
Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60                  
Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile
65                  70                  75                  80  
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr
                85                  90                  95      
Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp
            100                 105                 110         
Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser
        115                 120                 125             
His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser
    130                 135                 140                 
Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr
145                 150                 155                 160 
Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val
                165                 170                 175     
Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly
            180                 185                 190         
Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr
        195                 200                 205             
Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn
    210                 215                 220                 
Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp
225                 230                 235                 240 
Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val
                245                 250                 255     
Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu
            260                 265                 270         
Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala
        275                 280                 285             
Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala
    290                 295                 300                 
Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys
305                 310                 315                 320 
Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser
                325                 330                 335     
Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val
            340                 345                 350         
Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu
        355                 360                 365             
Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu
    370                 375                 380                 
Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln
385                 390                 395                 400 
Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr
                405                 410                 415     
Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile
            420                 425                 430         
Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu
        435                 440                 445             
Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr
    450                 455                 460                 
His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu
465                 470                 475                 480 
Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu
                485                 490                 495     
Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro
            500                 505                 510         
Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val
        515                 520                 525             
Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala
    530                 535                 540                 
His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu
545                 550                 555                 560 
Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys
                565                 570                 575     
Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly
            580                 585                 590         
Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn
        595                 600                 605             
Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro
    610                 615                 620                 
Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr
625                 630                 635                 640 
His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe
                645                 650                 655     
Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln
            660                 665                 670         
Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu
        675                 680                 685             
Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe
    690                 695                 700                 
Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe
705                 710                 715                 720 
Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys
                725                 730                 735     
Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser
            740                 745                 750         
Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His
        755                 760                 765             
Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln
    770                 775                 780                 
Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg
785                 790                 795                 800 
Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val
                805                 810                 815     
Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His
            820                 825                 830         
Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val
        835                 840                 845             
Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys
    850                 855                 860                 
Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu
865                 870                 875                 880 
Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser
                885                 890                 895     
Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr
            900                 905                 910         
Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu
        915                 920                 925             
Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met
    930                 935                 940                 
Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu
945                 950                 955                 960 
Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu
                965                 970                 975     
Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro
            980                 985                 990         
His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu
        995                 1000                1005            
Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr
    1010                1015                1020                
Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg
1025                1030                1035                1040
Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro
                1045                1050                1055    
Met Asn Gln Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser
            1060                1065                1070        
Gly Ser Ser Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro
        1075                1080                1085            
Arg Gly Cys Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser
    1090                1095                1100                
Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg
1105                1110                1115                1120
Ser Arg Ser Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg
                1125                1130                1135    
His Ser Leu Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu
            1140                1145                1150        
Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly
        1155                1160                1165            
Thr Pro Ser Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser
    1170                1175                1180                
Val Leu Gly Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met
1185                1190                1195                1200
Asn Arg Arg Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser
                1205                1210                1215    
Leu Glu Glu Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser
            1220                1225                1230        
Ala Ser Leu Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile
        1235                1240                1245            
Met Pro Thr Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn
    1250                1255                1260                
Arg Gln Arg Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly
1265                1270                1275                1280
Ala Cys Pro Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln
                1285                1290                1295    
Gly Pro Gly His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr
            1300                1305                1310        
Leu Arg Ser Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr
        1315                1320                1325            
Trp His Ser Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr
    1330                1335                1340        


<210> 9027
<211> 521
<212> PRT
<213> Homo sapiens

<400> 9027
Val Ser Leu Pro Phe Ser Phe Phe Ser Ser Phe Leu Phe Phe Ile Tyr
 1               5                  10                  15      
Ile Phe Trp His Cys Phe Ala Asp Val Gly Met Arg Val Gly Ala Glu
            20                  25                  30          
Tyr Gln Ala Arg Ile Pro Glu Phe Asp Pro Gly Ala Thr Lys Tyr Thr
        35                  40                  45              
Asp Lys Asp Asn Gly Gly Met Leu Val Trp Ser Pro Tyr His Ser Ile
    50                  55                  60                  
Pro Asp Ala Lys Leu Asp Glu Tyr Ile Ala Ile Ala Lys Glu Lys His
65                  70                  75                  80  
Gly Tyr Asn Val Glu Gln Ala Leu Gly Met Leu Phe Trp His Lys His
                85                  90                  95      
Asn Ile Glu Lys Ser Leu Ala Asp Leu Pro Asn Phe Thr Pro Phe Pro
            100                 105                 110         
Asp Glu Trp Thr Val Glu Asp Lys Val Leu Phe Glu Gln Ala Phe Ser
        115                 120                 125             
Phe His Gly Lys Ser Phe His Arg Ile Gln Gln Met Leu Pro Asp Lys
    130                 135                 140                 
Thr Ile Ala Ser Leu Val Lys Tyr Tyr Tyr Ser Trp Lys Lys Thr Arg
145                 150                 155                 160 
Ser Arg Thr Ser Leu Met Asp Arg Gln Ala Arg Lys Leu Ala Asn Arg
                165                 170                 175     
His Asn Gln Gly Asp Ser Asp Asp Asp Val Glu Glu Thr His Pro Met
            180                 185                 190         
Asp Gly Asn Asp Ser Asp Tyr Asp Pro Lys Lys Glu Ala Lys Lys Glu
        195                 200                 205             
Gly Asn Thr Glu Gln Pro Val Gln Thr Ser Lys Ile Gly Leu Gly Arg
    210                 215                 220                 
Arg Glu Tyr Gln Ser Leu Gln His Arg His His Ser Gln Arg Ser Lys
225                 230                 235                 240 
Cys Arg Pro Pro Lys Gly Met Tyr Leu Thr Gln Glu Asp Val Val Ala
                245                 250                 255     
Val Ser Cys Ser Pro Asn Ala Ala Asn Thr Ile Leu Arg Gln Leu Asp
            260                 265                 270         
Met Glu Leu Ile Ser Leu Lys Arg Gln Val Gln Asn Ala Lys Gln Val
        275                 280                 285             
Asn Ser Ala Leu Lys Gln Lys Met Glu Gly Gly Ile Glu Glu Phe Lys
    290                 295                 300                 
Pro Pro Glu Ser Asn Gln Lys Ile Asn Ala Arg Trp Thr Thr Glu Glu
305                 310                 315                 320 
Gln Leu Leu Ala Val Gln Gly Val Arg Lys Tyr Gly Lys Asp Phe Gln
                325                 330                 335     
Ala Ile Ala Asp Val Ile Gly Asn Lys Thr Val Gly Gln Val Lys Asn
            340                 345                 350         
Phe Phe Val Asn Tyr Arg Arg Arg Phe Asn Leu Glu Glu Val Leu Gln
        355                 360                 365             
Glu Trp Glu Ala Glu Gln Gly Thr Gln Ala Ser Asn Gly Asp Ala Ser
    370                 375                 380                 
Thr Leu Gly Glu Glu Thr Lys Ser Ala Ser Asn Val Pro Ser Gly Lys
385                 390                 395                 400 
Ser Thr Asp Glu Glu Glu Glu Ala Gln Thr Pro Gln Ala Pro Arg Thr
                405                 410                 415     
Leu Gly Pro Ser Pro Pro Ala Pro Ser Ser Thr Pro Thr Pro Thr Ala
            420                 425                 430         
Pro Ile Ala Thr Leu Asn Gln Pro Pro Pro Leu Leu Arg Pro Thr Leu
        435                 440                 445             
Pro Ala Ala Pro Ala Leu His Arg Gln Pro Pro Pro Leu Gln Gln Gln
    450                 455                 460                 
Ala Arg Phe Ile Gln Pro Arg Pro Thr Leu Asn Gln Pro Pro Pro Pro
465                 470                 475                 480 
Leu Ile Arg Pro Ala Asn Ser Met Pro Pro Arg Leu Asn Pro Arg Pro
                485                 490                 495     
Val Leu Ser Thr Val Gly Gly Gln Gln Pro Pro Ser Leu Ile Gly Ile
            500                 505                 510         
Gln Thr Asp Ser Gln Ser Ser Leu His
        515                 520     


<210> 9028
<211> 437
<212> PRT
<213> Homo sapiens

<400> 9028
Met Pro Gly Met Met Glu Lys Gly Pro Glu Leu Leu Gly Lys Asn Arg
 1               5                  10                  15      
Ser Ala Asn Gly Ser Ala Lys Ser Pro Ala Gly Gly Gly Gly Ser Gly
            20                  25                  30          
Ala Ser Ser Thr Asn Gly Gly Leu His Tyr Ser Glu Pro Glu Ser Gly
        35                  40                  45              
Cys Ser Ser Asp Asp Glu His Gly Asp Val Gly Met Arg Val Gly Ala
    50                  55                  60                  
Glu Tyr Gln Ala Arg Ile Pro Glu Phe Asp Pro Gly Ala Thr Lys Tyr
65                  70                  75                  80  
Thr Asp Lys Asp Asn Gly Gly Met Leu Val Trp Ser Pro Tyr His Ser
                85                  90                  95      
Ile Pro Asp Ala Lys Leu Asp Glu Tyr Ile Ala Ile Ala Lys Glu Lys
            100                 105                 110         
His Gly Tyr Asn Val Glu Gln Ala Leu Gly Met Leu Phe Trp His Lys
        115                 120                 125             
His Asn Ile Glu Lys Ser Leu Ala Asp Leu Pro Asn Phe Thr Pro Phe
    130                 135                 140                 
Pro Asp Glu Trp Thr Val Glu Asp Lys Val Leu Phe Glu Gln Ala Phe
145                 150                 155                 160 
Ser Phe His Gly Lys Ser Phe His Arg Ile Gln Gln Met Leu Pro Asp
                165                 170                 175     
Lys Thr Ile Ala Ser Leu Val Lys Tyr Tyr Tyr Ser Trp Lys Lys Thr
            180                 185                 190         
Arg Ser Arg Thr Ser Leu Met Asp Arg Gln Ala Arg Lys Leu Ala Asn
        195                 200                 205             
Arg His Asn Gln Gly Asp Ser Asp Asp Asp Val Glu Glu Thr His Pro
    210                 215                 220                 
Met Asp Gly Asn Asp Ser Asp Tyr Asp Pro Lys Lys Glu Ala Lys Lys
225                 230                 235                 240 
Glu Gly Asn Thr Glu Gln Pro Val Gln Thr Ser Lys Ile Gly Leu Gly
                245                 250                 255     
Arg Arg Glu Tyr Gln Ser Leu Gln His Arg His His Ser Gln Arg Ser
            260                 265                 270         
Lys Cys Arg Pro Pro Lys Gly Met Tyr Leu Thr Gln Glu Asp Val Val
        275                 280                 285             
Ala Val Ser Cys Ser Pro Asn Ala Ala Asn Thr Ile Leu Arg Gln Leu
    290                 295                 300                 
Asp Met Glu Leu Ile Ser Leu Lys Arg Gln Val Gln Asn Ala Lys Gln
305                 310                 315                 320 
Val Asn Ser Ala Leu Lys Gln Lys Met Glu Gly Gly Ile Glu Glu Phe
                325                 330                 335     
Lys Pro Pro Glu Ser Asn Gln Lys Ile Asn Ala Arg Trp Thr Thr Glu
            340                 345                 350         
Glu Gln Leu Leu Ala Val Gln Gly Thr Asp Pro Thr Gly Ser Ser Asp
        355                 360                 365             
Thr Gly Ser Ile Thr Ser Cys Pro Ile Ile His Ser Asn Thr Asn Ser
    370                 375                 380                 
Pro Tyr Cys His Ser Glu Pro Ala Ser Thr Thr Ser Ser Ser Asn Thr
385                 390                 395                 400 
Ala Cys Cys Pro Gly Ser Ser Pro Ala Ala Ser Ser Thr Pro Ala Ala
                405                 410                 415     
Gly Ser Val His Pro Ala Pro Ala Asn Phe Lys Ser Ala Ser Thr Thr
            420                 425                 430         
Ser Tyr Ser Pro Cys
        435         


<210> 9029
<211> 1049
<212> PRT
<213> Homo sapiens

<400> 9029
Met Asp Trp Ser Phe Phe Arg Val Val Ala Val Leu Phe Ile Phe Leu
 1               5                  10                  15      
Val Val Val Glu Val Asn Ser Glu Phe Arg Ile Gln Val Arg Asp Tyr
            20                  25                  30          
Asn Thr Lys Asn Gly Thr Ile Lys Trp His Ser Ile Arg Arg Gln Lys
        35                  40                  45              
Arg Glu Trp Ile Lys Phe Ala Ala Ala Cys Arg Glu Gly Glu Asp Asn
    50                  55                  60                  
Ser Lys Arg Asn Pro Ile Ala Lys Ile His Ser Asp Cys Ala Ala Asn
65                  70                  75                  80  
Gln Gln Val Thr Tyr Arg Ile Ser Gly Val Gly Ile Asp Gln Pro Pro
                85                  90                  95      
Tyr Gly Ile Phe Val Ile Asn Gln Lys Thr Gly Glu Ile Asn Ile Thr
            100                 105                 110         
Ser Ile Val Asp Arg Glu Val Thr Pro Phe Phe Ile Ile Tyr Cys Arg
        115                 120                 125             
Ala Leu Asn Ser Met Gly Gln Asp Leu Glu Arg Pro Leu Glu Leu Arg
    130                 135                 140                 
Val Arg Val Leu Asp Ile Asn Asp Asn Pro Pro Val Phe Ser Met Ala
145                 150                 155                 160 
Thr Phe Ala Gly Gln Ile Glu Glu Asn Ser Asn Ala Asn Thr Leu Val
                165                 170                 175     
Met Ile Leu Asn Ala Thr Asp Ala Asp Glu Pro Asn Asn Leu Asn Ser
            180                 185                 190         
Lys Ile Ala Phe Lys Ile Ile Arg Gln Glu Pro Ser Asp Ser Pro Met
        195                 200                 205             
Phe Ile Ile Asn Arg Asn Thr Gly Glu Ile Arg Thr Met Asn Asn Phe
    210                 215                 220                 
Leu Asp Arg Glu Gln Tyr Gly Gln Tyr Ala Leu Ala Val Arg Gly Ser
225                 230                 235                 240 
Asp Arg Asp Gly Gly Ala Asp Gly Met Ser Ala Glu Cys Glu Cys Asn
                245                 250                 255     
Ile Lys Ile Leu Asp Val Asn Asp Asn Ile Pro Tyr Met Glu Gln Ser
            260                 265                 270         
Ser Tyr Thr Ile Glu Ile Gln Glu Asn Thr Leu Asn Ser Asn Leu Leu
        275                 280                 285             
Glu Ile Arg Val Ile Asp Leu Asp Glu Glu Phe Ser Ala Asn Trp Met
    290                 295                 300                 
Ala Val Ile Phe Phe Ile Ser Gly Asn Glu Gly Asn Trp Phe Glu Ile
305                 310                 315                 320 
Glu Met Asn Glu Arg Thr Asn Val Gly Ile Leu Lys Val Val Lys Pro
                325                 330                 335     
Leu Asp Tyr Glu Ala Met Gln Ser Leu Gln Leu Ser Ile Gly Val Arg
            340                 345                 350         
Asn Lys Ala Glu Phe His His Ser Ile Met Ser Gln Tyr Lys Leu Lys
        355                 360                 365             
Ala Ser Ala Ile Ser Val Thr Val Leu Asn Val Ile Glu Gly Pro Val
    370                 375                 380                 
Phe Arg Pro Gly Ser Lys Thr Tyr Val Val Thr Gly Asn Met Gly Ser
385                 390                 395                 400 
Asn Asp Lys Val Gly Asp Phe Val Ala Thr Asp Leu Asp Thr Gly Arg
                405                 410                 415     
Pro Ser Thr Thr Val Arg Tyr Val Met Gly Asn Asn Pro Ala Asp Leu
            420                 425                 430         
Leu Ala Val Asp Ser Arg Thr Gly Lys Leu Thr Leu Lys Asn Lys Val
        435                 440                 445             
Thr Lys Glu Gln Tyr Asn Met Leu Gly Gly Lys Tyr Gln Gly Thr Ile
    450                 455                 460                 
Leu Ser Ile Asp Asp Asn Leu Gln Arg Thr Cys Thr Gly Thr Ile Asn
465                 470                 475                 480 
Ile Asn Ile Gln Ser Phe Gly Asn Asp Asp Arg Thr Asn Thr Glu Pro
                485                 490                 495     
Asn Thr Lys Ile Thr Thr Asn Thr Gly Arg Gln Glu Ser Thr Ser Ser
            500                 505                 510         
Thr Asn Tyr Asp Thr Ser Thr Thr Ser Thr Asp Ser Ser Gln Val Tyr
        515                 520                 525             
Ser Ser Glu Pro Gly Asn Gly Ala Lys Asp Leu Leu Ser Asp Asn Val
    530                 535                 540                 
His Phe Gly Pro Ala Gly Ile Gly Leu Leu Ile Met Gly Phe Leu Val
545                 550                 555                 560 
Leu Gly Leu Val Pro Phe Leu Met Ile Cys Cys Asp Cys Gly Gly Ala
                565                 570                 575     
Pro Arg Ser Ala Ala Gly Phe Glu Pro Val Pro Glu Cys Ser Asp Gly
            580                 585                 590         
Ala Ile His Ser Trp Ala Val Glu Gly Pro Gln Pro Glu Pro Arg Asp
        595                 600                 605             
Ile Thr Thr Val Ile Pro Gln Ile Pro Pro Asp Asn Ala Asn Ile Ile
    610                 615                 620                 
Glu Cys Ile Asp Asn Ser Gly Val Tyr Thr Asn Glu Tyr Gly Gly Arg
625                 630                 635                 640 
Glu Met Gln Asp Leu Gly Gly Gly Glu Arg Met Thr Gly Phe Glu Leu
                645                 650                 655     
Thr Glu Gly Val Lys Thr Ser Gly Met Pro Glu Ile Cys Gln Glu Tyr
            660                 665                 670         
Ser Gly Thr Leu Arg Arg Asn Ser Met Arg Glu Cys Arg Glu Gly Gly
        675                 680                 685             
Leu Asn Met Asn Phe Met Glu Ser Tyr Phe Cys Gln Lys Ala Tyr Ala
    690                 695                 700                 
Tyr Ala Asp Glu Asp Glu Gly Arg Pro Ser Asn Asp Cys Leu Leu Ile
705                 710                 715                 720 
Tyr Asp Ile Glu Gly Val Gly Ser Pro Ala Gly Ser Val Gly Cys Cys
                725                 730                 735     
Ser Phe Ile Gly Glu Asp Leu Asp Asp Ser Phe Leu Asp Thr Leu Gly
            740                 745                 750         
Pro Lys Phe Lys Lys Leu Ala Asp Ile Ser Leu Gly Lys Glu Ser Tyr
        755                 760                 765             
Pro Asp Leu Asp Pro Ser Trp Pro Pro Gln Ser Thr Glu Pro Val Cys
    770                 775                 780                 
Leu Pro Gln Glu Thr Glu Pro Val Val Ser Gly His Pro Pro Ile Ser
785                 790                 795                 800 
Pro His Phe Gly Thr Thr Thr Val Ile Ser Glu Ser Thr Tyr Pro Ser
                805                 810                 815     
Gly Pro Gly Val Leu His Pro Lys Pro Ile Leu Asp Pro Leu Gly Tyr
            820                 825                 830         
Gly Asn Val Thr Val Thr Glu Ser Tyr Thr Thr Ser Asp Thr Leu Lys
        835                 840                 845             
Pro Ser Val His Val His Asp Asn Arg Pro Ala Ser Asn Val Val Val
    850                 855                 860                 
Thr Glu Arg Val Val Gly Pro Ile Ser Gly Ala Asp Leu His Gly Met
865                 870                 875                 880 
Leu Glu Met Pro Asp Leu Arg Asp Gly Ser Asn Val Ile Val Thr Glu
                885                 890                 895     
Arg Val Ile Ala Pro Ser Ser Ser Leu Pro Thr Ser Leu Thr Ile His
            900                 905                 910         
His Pro Arg Glu Ser Ser Asn Val Val Val Thr Glu Arg Val Ile Gln
        915                 920                 925             
Pro Thr Ser Gly Met Ile Gly Ser Leu Ser Met His Pro Glu Leu Ala
    930                 935                 940                 
Asn Ala His Asn Val Ile Val Thr Glu Arg Val Val Ser Gly Ala Gly
945                 950                 955                 960 
Val Thr Gly Ile Ser Gly Thr Thr Gly Ile Ser Gly Gly Ile Gly Ser
                965                 970                 975     
Ser Gly Leu Val Gly Thr Ser Met Gly Ala Gly Ser Gly Ala Leu Ser
            980                 985                 990         
Gly Ala Gly Ile Ser Gly Gly Gly Ile Gly Leu Ser Ser Leu Gly Gly
        995                 1000                1005            
Thr Ala Ser Ile Gly His Met Arg Ser Ser Ser Asp His His Phe Asn
    1010                1015                1020                
Gln Thr Ile Gly Ser Ala Ser Pro Ser Thr Ala Arg Ser Arg Ile Thr
1025                1030                1035                1040
Lys Tyr Ser Thr Val Gln Tyr Ser Lys
                1045                


<210> 9030
<211> 358
<212> PRT
<213> Homo sapiens

<400> 9030
Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu
 1               5                  10                  15      
Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val
            20                  25                  30          
Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu
        35                  40                  45              
Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln
    50                  55                  60                  
Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser
65                  70                  75                  80  
Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp
                85                  90                  95      
Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp
            100                 105                 110         
Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile
        115                 120                 125             
Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu
    130                 135                 140                 
Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala
145                 150                 155                 160 
Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg
                165                 170                 175     
Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val
            180                 185                 190         
Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu
        195                 200                 205             
Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe
    210                 215                 220                 
Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg
225                 230                 235                 240 
Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp
                245                 250                 255     
Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly
            260                 265                 270         
Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser
        275                 280                 285             
Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu
    290                 295                 300                 
Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile
305                 310                 315                 320 
Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg
                325                 330                 335     
Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr
            340                 345                 350         
Asn Gly Leu Gln Gly Tyr
        355             


<210> 9031
<211> 530
<212> PRT
<213> Homo sapiens

<400> 9031
Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp
 1               5                  10                  15      
Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg
            20                  25                  30          
Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu
        35                  40                  45              
Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser
    50                  55                  60                  
Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val
65                  70                  75                  80  
Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr
                85                  90                  95      
Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr
            100                 105                 110         
Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr
        115                 120                 125             
Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser
    130                 135                 140                 
Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val
145                 150                 155                 160 
Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr
                165                 170                 175     
Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala
            180                 185                 190         
Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu
        195                 200                 205             
Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu
    210                 215                 220                 
Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe
225                 230                 235                 240 
Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn
                245                 250                 255     
Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg
            260                 265                 270         
Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys
        275                 280                 285             
Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu
    290                 295                 300                 
Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro
305                 310                 315                 320 
Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser
                325                 330                 335     
Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe
            340                 345                 350         
Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu
        355                 360                 365             
Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala
    370                 375                 380                 
Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala
385                 390                 395                 400 
Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile
                405                 410                 415     
Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr
            420                 425                 430         
Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp
        435                 440                 445             
Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu
    450                 455                 460                 
Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile
465                 470                 475                 480 
Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys
                485                 490                 495     
Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys
            500                 505                 510         
Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu
        515                 520                 525             
Arg Arg
    530 


<210> 9032
<211> 431
<212> PRT
<213> Homo sapiens

<400> 9032
Met Met Leu Arg Phe Ser Met Cys Arg Gly Asn Asp Glu Gly Phe Ala
 1               5                  10                  15      
Met Glu Gln Ile Trp Leu Leu Leu Leu Leu Thr Ile Arg Val Leu Pro
            20                  25                  30          
Gly Ser Ala Gln Phe Asn Gly Tyr Asn Cys Asp Ala Asn Leu His Ser
        35                  40                  45              
Arg Phe Pro Ala Glu Arg Asp Ile Ser Val Tyr Cys Gly Val Gln Ala
    50                  55                  60                  
Ile Thr Met Lys Ile Asn Phe Cys Thr Val Leu Phe Ser Gly Tyr Ser
65                  70                  75                  80  
Glu Thr Asp Leu Ala Leu Asn Gly Arg His Gly Asp Ser His Cys Arg
                85                  90                  95      
Gly Phe Ile Asn Asn Asn Thr Phe Pro Ala Val Val Ile Phe Ile Ile
            100                 105                 110         
Asn Leu Ser Thr Leu Glu Gly Cys Gly Asn Asn Leu Val Val Ser Thr
        115                 120                 125             
Ile Pro Gly Val Ser Ala Tyr Gly Asn Ala Thr Ser Val Gln Val Gly
    130                 135                 140                 
Asn Ile Ser Gly Tyr Ile Asp Thr Pro Asp Pro Pro Thr Ile Ile Ser
145                 150                 155                 160 
Tyr Leu Pro Gly Leu Leu Tyr Lys Phe Ser Cys Ser Tyr Pro Leu Glu
                165                 170                 175     
Tyr Leu Val Asn Asn Thr Gln Leu Ala Ser Ser Ser Ala Ala Ile Ser
            180                 185                 190         
Val Arg Glu Asn Asn Gly Thr Phe Val Ser Thr Leu Asn Leu Leu Leu
        195                 200                 205             
Tyr Asn Asp Ser Thr Tyr Asn Gln Gln Leu Ile Ile Pro Ser Ile Gly
    210                 215                 220                 
Leu Pro Leu Lys Thr Lys Val Phe Ala Ala Val Gln Ala Thr Asn Leu
225                 230                 235                 240 
Asp Gly Arg Trp Asn Val Leu Met Asp Tyr Cys Tyr Thr Thr Pro Ser
                245                 250                 255     
Gly Asn Pro Asn Asp Asp Ile Arg Tyr Asp Leu Phe Leu Ser Cys Asp
            260                 265                 270         
Lys Asp Pro Gln Thr Thr Val Ile Glu Asn Gly Arg Ser Gln Arg Gly
        275                 280                 285             
Arg Phe Ser Phe Glu Val Phe Arg Phe Val Lys His Lys Asn Gln Lys
    290                 295                 300                 
Met Ser Thr Val Phe Leu His Cys Val Thr Lys Leu Cys Arg Ala Asp
305                 310                 315                 320 
Asp Cys Pro Phe Leu Met Pro Ile Cys Ser His Arg Glu Arg Arg Asp
                325                 330                 335     
Ala Gly Arg Arg Thr Thr Trp Ser Pro Gln Ser Ser Ser Gly Ser Ala
            340                 345                 350         
Val Leu Ser Ala Gly Pro Ile Ile Thr Arg Ser Asp Glu Thr Pro Thr
        355                 360                 365             
Asn Asn Ser Gln Leu Gly Ser Pro Ser Met Pro Pro Phe Gln Leu Asn
    370                 375                 380                 
Ala Ile Thr Ser Ala Leu Ile Ser Gly Met Val Ile Leu Gly Val Thr
385                 390                 395                 400 
Ser Phe Ser Leu Leu Leu Cys Ser Leu Ala Leu Leu His Arg Lys Gly
                405                 410                 415     
Pro Thr Ser Leu Val Leu Asn Gly Ile Arg Asn Pro Val Phe Asp
            420                 425                 430     


<210> 9033
<211> 498
<212> PRT
<213> Homo sapiens

<400> 9033
Pro Val Pro Gly Arg Leu Gly Pro Leu Leu Cys Leu Leu Leu Pro Ala
 1               5                  10                  15      
Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu Glu Leu Gln Val Ile
            20                  25                  30          
Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu Ser Ala Ala Leu
        35                  40                  45              
Gln Cys Thr Val Thr Ser Leu Asn Pro Val Gly Pro Ile Gln Arg Phe
    50                  55                  60                  
Arg Gly Ala Gly Pro Gly Arg Lys Leu Ile Tyr His Gln Lys Glu Gly
65                  70                  75                  80  
His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys Arg Thr Asn
                85                  90                  95      
Met Asp Phe Ser Ile Cys Ile Ser Asn Ile Thr Pro Ala Asp Ala Gly
            100                 105                 110         
Thr Tyr Tyr Cys Val Lys Phe Gln Lys Gly Ser Pro Asp Val Glu Leu
        115                 120                 125             
Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala
    130                 135                 140                 
Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr Pro Asp His Thr Val
145                 150                 155                 160 
Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp Ile Ser Leu
                165                 170                 175     
Lys Trp Phe Lys Asn Gly Asn Gln Leu Ser Asp Phe Gln Thr Asn Val
            180                 185                 190         
Asp Pro Ala Arg Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Asn
        195                 200                 205             
Val Val Leu Thr Arg Gly Asp Ile His Ser Gln Val Ile Cys Glu Val
    210                 215                 220                 
Ala His Val Thr Leu Arg Gly Asp Ser Phe Arg Gly Thr Ala Asn Leu
225                 230                 235                 240 
Ser Glu Thr Ile Gln Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro
                245                 250                 255     
Met Arg Ala Glu Asn Gln Val Asn Ile Thr Cys Gln Val Thr Lys Phe
            260                 265                 270         
Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser
        275                 280                 285             
Arg Thr Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys Asp Gly Thr Tyr
    290                 295                 300                 
Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp
305                 310                 315                 320 
Val Lys Leu Thr Cys Gln Val Glu His Asp Gly Gln Ser Ala Val Ser
                325                 330                 335     
Lys Ser His Asp Leu Lys Val Ser Ala His Leu Lys Glu Gln Ser Ser
            340                 345                 350         
Asn Thr Ala Ala Glu Asn Thr Gly Pro Asn Glu Gln Asn Ile Tyr Ile
        355                 360                 365             
Val Val Gly Val Val Cys Thr Leu Leu Val Ala Leu Leu Met Glu Ala
    370                 375                 380                 
Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys Ala Gln Gly Ser Thr Ser
385                 390                 395                 400 
Ser Thr Arg Leu His Glu Pro Glu Lys Asn Ala Arg Lys Ile Thr Gln
                405                 410                 415     
Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Gly Lys
            420                 425                 430         
Lys Pro Ala Pro Arg Ala Ala Glu Pro Asn Asn His Thr Glu Tyr Ala
        435                 440                 445             
Ser Ile Gln Thr Ser Leu Gln Pro Ala Ser Glu Asp Thr Leu Thr Tyr
    450                 455                 460                 
Ala Asp Leu Asp Met Val His Leu Asn Arg Thr Pro Lys Gln Leu Ala
465                 470                 475                 480 
Pro Lys Pro Glu Leu Ser Phe Ser Glu Tyr Ala Ser Ile Gln Val Pro
                485                 490                 495     
Arg Lys
        


<210> 9034
<211> 1505
<212> PRT
<213> Homo sapiens

<400> 9034
Met Trp Val Ala Lys Trp Leu Thr Gly Leu Leu Tyr His Leu Ser Leu
 1               5                  10                  15      
Phe Ile Thr Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala
            20                  25                  30          
Leu Val Arg Thr Leu Thr Ser Tyr Glu Val Val Ile Pro Glu Arg Val
        35                  40                  45              
Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln
    50                  55                  60                  
Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Thr His Tyr
65                  70                  75                  80  
Arg Phe Thr Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Thr Ala Asp
                85                  90                  95      
Ala Ser Phe Leu Ala Ala Gly Tyr Thr Glu Val His Leu Gly Thr Pro
            100                 105                 110         
Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His
        115                 120                 125             
Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val
    130                 135                 140                 
Val Ser Leu Cys Gly Gly Leu Thr Gly Thr Phe Lys Gly Gln Asn Gly
145                 150                 155                 160 
Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu
                165                 170                 175     
Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn
            180                 185                 190         
Ser Phe Leu Gln Thr Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile
        195                 200                 205             
Lys Glu Thr Ser Leu Pro Phe His Thr Tyr Ser Asn Met Asn Glu Asp
    210                 215                 220                 
Leu Asn Val Met Lys Glu Arg Val Leu Gly His Thr Ser Lys Asn Val
225                 230                 235                 240 
Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser
                245                 250                 255     
Tyr Pro Arg Tyr Ile Glu Ile Met Val Thr Ala Asp Ala Lys Val Val
            260                 265                 270         
Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Thr Leu Met Ser
        275                 280                 285             
Ile Val Ala Thr Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His
    290                 295                 300                 
Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro
305                 310                 315                 320 
Val Ile Asn Phe Asp Gly Ala Thr Thr Leu Lys Asn Phe Cys Ser Trp
                325                 330                 335     
Gln Gln Thr Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp
            340                 345                 350         
Thr Ala Val Leu Ile Thr Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys
        355                 360                 365             
Cys Asn Thr Leu Gly Leu Ser Tyr Leu Gly Thr Ile Cys Asp Pro Leu
    370                 375                 380                 
Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Thr
385                 390                 395                 400 
Ile Ala His Glu Leu Gly His Thr Leu Gly Val Gln His Asp Asp Asn
                405                 410                 415     
Pro Arg Cys Lys Glu Met Lys Val Thr Lys Tyr His Val Met Ala Pro
            420                 425                 430         
Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg
        435                 440                 445             
Lys Tyr Val Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu
    450                 455                 460                 
Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly
465                 470                 475                 480 
Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly
                485                 490                 495     
Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Thr
            500                 505                 510         
Ser Thr Glu Lys Leu His Lys Gly Cys Phe Thr Gln His Val Pro Pro
        515                 520                 525             
Ala Asp Gly Thr Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu
    530                 535                 540                 
Cys Val Asn Lys Glu Thr Glu Thr Arg Pro Val Asn Gly Glu Trp Gly
545                 550                 555                 560 
Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Thr Cys Gly Gly Gly Ile
                565                 570                 575     
Glu Ser Ala Thr Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly
            580                 585                 590         
Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Thr Asp
        595                 600                 605             
Ser Cys Pro Lys Gly Thr Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp
    610                 615                 620                 
Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg
625                 630                 635                 640 
Trp Leu Pro Arg Tyr Ser Gly Ile Gly Thr Lys Asp Arg Cys Lys Leu
                645                 650                 655     
Tyr Cys Gln Val Ala Gly Thr Asn Tyr Phe Tyr Leu Leu Lys Asp Met
            660                 665                 670         
Val Glu Asp Gly Thr Pro Cys Gly Thr Glu Ser Tyr Asn Ile Asp Cys
        675                 680                 685             
Asn Cys Val Leu Lys Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser
    690                 695                 700                 
Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys
705                 710                 715                 720 
Lys Thr Ile Thr Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val
                725                 730                 735     
Val Val Lys Ile Pro Ala Gly Ala Thr Asn Val Asp Ile Arg Gln Tyr
            740                 745                 750         
Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala
        755                 760                 765             
Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Thr Ser Lys
    770                 775                 780                 
Lys Glu Ile Asn Val Gln Gly Thr Arg Thr Val Ile Glu Tyr Ser Gly
785                 790                 795                 800 
Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Thr Asn Arg Gln Glu Lys
                805                 810                 815     
Glu Leu Ile Leu Gln Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp
            820                 825                 830         
Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe
        835                 840                 845             
Thr Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln
    850                 855                 860                 
Gly Leu Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser
865                 870                 875                 880 
Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val
                885                 890                 895     
Thr Gln Ser Cys Asn Thr Asp Cys Glu Leu Arg Gly Met Leu Leu Ala
            900                 905                 910         
Lys Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu
        915                 920                 925             
Asp Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln
    930                 935                 940                 
Val Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu
945                 950                 955                 960 
Leu Cys His Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp
                965                 970                 975     
Ser Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser
            980                 985                 990         
Tyr Cys Met Asn Asn Phe Gly His Arg Leu Ala Asp Asn Glu Cys Gln
        995                 1000                1005            
Glu Leu Ser Arg Val Thr Arg Glu Asn Cys Asn Glu Phe Ser Cys Pro
    1010                1015                1020                
Ser Trp Ala Ala Ser Glu Trp Ser Glu Cys Leu Val Thr Cys Gly Lys
1025                1030                1035                1040
Gly Thr Lys Gln Arg Gln Val Trp Cys Gln Leu Asn Val Asp His Leu
                1045                1050                1055    
Ser Asp Gly Phe Cys Asn Ser Ser Thr Lys Pro Glu Ser Leu Ser Pro
            1060                1065                1070        
Cys Glu Leu His Thr Cys Ala Ser Trp Gln Val Gly Pro Trp Gly Pro
        1075                1080                1085            
Cys Thr Thr Thr Cys Gly His Gly Tyr Gln Met Arg Asp Val Lys Cys
    1090                1095                1100                
Val Asn Glu Leu Ala Ser Ala Val Leu Glu Asp Thr Glu Cys His Glu
1105                1110                1115                1120
Ala Ser Arg Pro Ser Asp Arg Gln Ser Cys Val Leu Thr Pro Cys Ser
                1125                1130                1135    
Phe Ile Ser Lys Leu Glu Thr Ala Leu Leu Pro Thr Val Leu Ile Lys
            1140                1145                1150        
Lys Met Ala Gln Trp Arg His Gly Ser Trp Thr Pro Cys Ser Val Ser
        1155                1160                1165            
Cys Gly Arg Gly Thr Gln Ala Arg Tyr Val Ser Cys Arg Asp Ala Leu
    1170                1175                1180                
Asp Arg Ile Ala Asp Glu Ser Tyr Cys Ala His Leu Pro Arg Pro Ala
1185                1190                1195                1200
Glu Ile Trp Asp Cys Phe Thr Pro Cys Gly Glu Trp Gln Ala Gly Asp
                1205                1210                1215    
Trp Ser Pro Cys Ser Ala Ser Cys Gly His Gly Lys Thr Thr Arg Gln
            1220                1225                1230        
Val Leu Cys Met Asn Tyr His Gln Pro Ile Asp Glu Asn Tyr Cys Asp
        1235                1240                1245            
Pro Glu Val Arg Pro Leu Met Glu Gln Glu Cys Ser Leu Ala Ala Cys
    1250                1255                1260                
Pro Pro Ala His Ser His Phe Pro Ser Ser Pro Val Gln Pro Ser Tyr
1265                1270                1275                1280
Tyr Leu Ser Thr Asn Leu Pro Leu Thr Gln Lys Leu Glu Asp Asn Glu
                1285                1290                1295    
Asn Gln Val Val His Pro Ser Val Arg Gly Asn Gln Trp Arg Thr Gly
            1300                1305                1310        
Pro Trp Gly Ser Cys Ser Ser Ser Cys Ser Gly Gly Leu Gln His Thr
        1315                1320                1325            
Ala Val Val Cys Gln Asp Glu Asn Gly Gln Ser Ala Ser Tyr Cys Asp
    1330                1335                1340                
Ala Ala Ser Lys Pro Pro Glu Leu Gln Gln Cys Gly Pro Gly Pro Cys
1345                1350                1355                1360
Pro Gln Trp Asn Tyr Gly Asn Trp Gly Glu Cys Ser Gln Thr Cys Gly
                1365                1370                1375    
Gly Gly Ile Lys Ser Arg Leu Val Ile Cys Gln Phe Pro Asn Gly Gln
            1380                1385                1390        
Ile Leu Glu Asp His Asn Cys Glu Ile Val Asn Lys Pro Pro Ser Val
        1395                1400                1405            
Ile Gln Cys His Met His Ala Cys Pro Ala Asp Val Ser Trp His Gln
    1410                1415                1420                
Glu Pro Trp Thr Ser Glu Asp Leu Lys Val Lys Leu Leu Pro Gln Arg
1425                1430                1435                1440
Thr Ile Ile Leu Trp Glu Leu Met Lys Asn Ile Phe Cys His Gly Lys
                1445                1450                1455    
His Ser His Met Tyr Leu Ile Asn Val Val Thr Asp His Leu Leu Tyr
            1460                1465                1470        
Pro Arg His Cys Asp Pro Glu Thr Ile Glu Thr Tyr Phe Leu Ser Leu
        1475                1480                1485            
Trp Ser Leu Gln Phe Thr Trp Gly Asp Leu Lys Tyr Tyr Lys Asn Ser
    1490                1495                1500                
Leu
1505


<210> 9035
<211> 1911
<212> PRT
<213> Homo sapiens

<400> 9035
Met Trp Val Ala Lys Trp Leu Thr Gly Leu Leu Tyr His Leu Ser Leu
 1               5                  10                  15      
Phe Ile Thr Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala
            20                  25                  30          
Leu Val Arg Thr Leu Thr Ser Tyr Glu Val Val Ile Pro Glu Arg Val
        35                  40                  45              
Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln
    50                  55                  60                  
Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Thr His Tyr
65                  70                  75                  80  
Arg Phe Thr Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Thr Ala Asp
                85                  90                  95      
Ala Ser Phe Leu Ala Ala Gly Tyr Thr Glu Val His Leu Gly Thr Pro
            100                 105                 110         
Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His
        115                 120                 125             
Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val
    130                 135                 140                 
Val Ser Leu Cys Gly Gly Leu Thr Gly Thr Phe Lys Gly Gln Asn Gly
145                 150                 155                 160 
Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu
                165                 170                 175     
Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn
            180                 185                 190         
Ser Phe Leu Gln Thr Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile
        195                 200                 205             
Lys Glu Thr Ser Leu Pro Phe His Thr Tyr Ser Asn Met Asn Glu Asp
    210                 215                 220                 
Leu Asn Val Met Lys Glu Arg Val Leu Gly His Thr Ser Lys Asn Val
225                 230                 235                 240 
Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser
                245                 250                 255     
Tyr Pro Arg Tyr Ile Glu Ile Met Val Thr Ala Asp Ala Lys Val Val
            260                 265                 270         
Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Thr Leu Met Ser
        275                 280                 285             
Ile Val Ala Thr Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His
    290                 295                 300                 
Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro
305                 310                 315                 320 
Val Ile Asn Phe Asp Gly Ala Thr Thr Leu Lys Asn Phe Cys Ser Trp
                325                 330                 335     
Gln Gln Thr Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp
            340                 345                 350         
Thr Ala Val Leu Ile Thr Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys
        355                 360                 365             
Cys Asn Thr Leu Gly Leu Ser Tyr Leu Gly Thr Ile Cys Asp Pro Leu
    370                 375                 380                 
Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Thr
385                 390                 395                 400 
Ile Ala His Glu Leu Gly His Thr Leu Gly Val Gln His Asp Asp Asn
                405                 410                 415     
Pro Arg Cys Lys Glu Met Lys Val Thr Lys Tyr His Val Met Ala Pro
            420                 425                 430         
Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg
        435                 440                 445             
Lys Tyr Val Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu
    450                 455                 460                 
Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly
465                 470                 475                 480 
Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly
                485                 490                 495     
Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Thr
            500                 505                 510         
Ser Thr Glu Lys Leu His Lys Gly Cys Phe Thr Gln His Val Pro Pro
        515                 520                 525             
Ala Asp Gly Thr Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu
    530                 535                 540                 
Cys Val Asn Lys Glu Thr Glu Thr Arg Pro Val Asn Gly Glu Trp Gly
545                 550                 555                 560 
Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Thr Cys Gly Gly Gly Ile
                565                 570                 575     
Glu Ser Ala Thr Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly
            580                 585                 590         
Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Thr Asp
        595                 600                 605             
Ser Cys Pro Lys Gly Thr Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp
    610                 615                 620                 
Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg
625                 630                 635                 640 
Trp Leu Pro Arg Tyr Ser Gly Ile Gly Thr Lys Asp Arg Cys Lys Leu
                645                 650                 655     
Tyr Cys Gln Val Ala Gly Thr Asn Tyr Phe Tyr Leu Leu Lys Asp Met
            660                 665                 670         
Val Glu Asp Gly Thr Pro Cys Gly Thr Glu Thr His Asp Ile Cys Val
        675                 680                 685             
Gln Gly Gln Cys Met Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser
    690                 695                 700                 
Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys
705                 710                 715                 720 
Lys Thr Ile Thr Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val
                725                 730                 735     
Val Val Lys Ile Pro Ala Gly Ala Thr Asn Val Asp Ile Arg Gln Tyr
            740                 745                 750         
Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala
        755                 760                 765             
Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Thr Ser Lys
    770                 775                 780                 
Lys Glu Ile Asn Val Gln Gly Thr Arg Thr Val Ile Glu Tyr Ser Gly
785                 790                 795                 800 
Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Thr Asn Arg Gln Glu Lys
                805                 810                 815     
Glu Leu Ile Leu Gln Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp
            820                 825                 830         
Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe
        835                 840                 845             
Thr Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln
    850                 855                 860                 
Gly Leu Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser
865                 870                 875                 880 
Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val
                885                 890                 895     
Thr Gln Ser Cys Asn Thr Asp Cys Glu Leu Arg Gly Met Leu Leu Ala
            900                 905                 910         
Lys Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu
        915                 920                 925             
Asp Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln
    930                 935                 940                 
Val Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu
945                 950                 955                 960 
Leu Cys His Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp
                965                 970                 975     
Ser Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser
            980                 985                 990         
Tyr Cys Met Asn Asn Phe Gly His Arg Leu Ala Asp Asn Glu Cys Gln
        995                 1000                1005            
Glu Leu Ser Arg Val Thr Arg Glu Asn Cys Asn Glu Phe Ser Cys Pro
    1010                1015                1020                
Ser Trp Ala Ala Ser Glu Trp Ser Glu Cys Leu Val Thr Cys Gly Lys
1025                1030                1035                1040
Gly Thr Lys Gln Arg Gln Val Trp Cys Gln Leu Asn Val Asp His Leu
                1045                1050                1055    
Ser Asp Gly Phe Cys Asn Ser Ser Thr Lys Pro Glu Ser Leu Ser Pro
            1060                1065                1070        
Cys Glu Leu His Thr Cys Ala Ser Trp Gln Val Gly Pro Trp Gly Pro
        1075                1080                1085            
Cys Thr Thr Thr Cys Gly His Gly Tyr Gln Met Arg Asp Val Lys Cys
    1090                1095                1100                
Val Asn Glu Leu Ala Ser Ala Val Leu Glu Asp Thr Glu Cys His Glu
1105                1110                1115                1120
Ala Ser Arg Pro Ser Asp Arg Gln Ser Cys Val Leu Thr Pro Cys Ser
                1125                1130                1135    
Phe Ile Ser Lys Leu Glu Thr Ala Leu Leu Pro Thr Val Leu Ile Lys
            1140                1145                1150        
Lys Met Ala Gln Trp Arg His Gly Ser Trp Thr Pro Cys Ser Val Ser
        1155                1160                1165            
Cys Gly Arg Gly Thr Gln Ala Arg Tyr Val Ser Cys Arg Asp Ala Leu
    1170                1175                1180                
Asp Arg Ile Ala Asp Glu Ser Tyr Cys Ala His Leu Pro Arg Pro Ala
1185                1190                1195                1200
Glu Ile Trp Asp Cys Phe Thr Pro Cys Gly Glu Trp Gln Ala Gly Asp
                1205                1210                1215    
Trp Ser Pro Cys Ser Ala Ser Cys Gly His Gly Lys Thr Thr Arg Gln
            1220                1225                1230        
Val Leu Cys Met Asn Tyr His Gln Pro Ile Asp Glu Asn Tyr Cys Asp
        1235                1240                1245            
Pro Glu Val Arg Pro Leu Met Glu Gln Glu Cys Ser Leu Ala Ala Cys
    1250                1255                1260                
Pro Pro Ala His Ser His Phe Pro Ser Ser Pro Val Gln Pro Ser Tyr
1265                1270                1275                1280
Tyr Leu Ser Thr Asn Leu Pro Leu Thr Gln Lys Leu Glu Asp Asn Glu
                1285                1290                1295    
Asn Gln Val Val His Pro Ser Val Arg Gly Asn Gln Trp Arg Thr Gly
            1300                1305                1310        
Pro Trp Gly Ser Cys Ser Ser Ser Cys Ser Gly Gly Leu Gln His Thr
        1315                1320                1325            
Ala Val Val Cys Gln Asp Glu Asn Gly Gln Ser Ala Ser Tyr Cys Asp
    1330                1335                1340                
Ala Ala Ser Lys Pro Pro Glu Leu Gln Gln Cys Gly Pro Gly Pro Cys
1345                1350                1355                1360
Pro Gln Trp Asn Tyr Gly Asn Trp Gly Glu Cys Ser Gln Thr Cys Gly
                1365                1370                1375    
Gly Gly Ile Lys Ser Arg Leu Val Ile Cys Gln Phe Pro Asn Gly Gln
            1380                1385                1390        
Ile Leu Glu Asp His Asn Cys Glu Ile Val Asn Lys Pro Pro Ser Val
        1395                1400                1405            
Ile Gln Cys His Met His Ala Cys Pro Ala Asp Val Ser Trp His Gln
    1410                1415                1420                
Glu Pro Trp Thr Ser Cys Ser Ala Ser Cys Gly Lys Gly Arg Lys Tyr
1425                1430                1435                1440
Arg Glu Val Phe Cys Ile Asp Gln Phe Gln Arg Lys Leu Glu Asp Thr
                1445                1450                1455    
Asn Cys Ser Gln Val Gln Lys Pro Pro Thr His Lys Ala Cys Arg Ser
            1460                1465                1470        
Val Arg Cys Pro Ser Trp Lys Ala Asn Ser Trp Asn Glu Cys Ser Val
        1475                1480                1485            
Thr Cys Gly Ser Gly Val Gln Gln Arg Asp Val Tyr Cys Arg Leu Lys
    1490                1495                1500                
Gly Val Gly Gln Val Val Glu Glu Met Cys Asp Gln Ser Thr Arg Pro
1505                1510                1515                1520
Cys Ser Gln Arg Arg Cys Trp Ser Gln Asp Cys Val Gln His Lys Gly
                1525                1530                1535    
Met Glu Arg Gly Arg Leu Asn Cys Ser Thr Ser Cys Glu Arg Lys Asp
            1540                1545                1550        
Ser His Gln Arg Met Glu Cys Thr Asp Asn Gln Ile Arg Gln Val Asn
        1555                1560                1565            
Glu Ile Val Tyr Asn Ser Ser Thr Ile Ser Leu Thr Ser Lys Asn Cys
    1570                1575                1580                
Arg Asn Pro Pro Cys Asn Tyr Ile Val Val Thr Ala Asp Ser Ser Gln
1585                1590                1595                1600
Cys Ala Asn Asn Cys Gly Phe Ser Tyr Arg Gln Arg Ile Thr Tyr Cys
                1605                1610                1615    
Thr Glu Ile Pro Ser Thr Lys Lys His Lys Leu His Arg Leu Arg Pro
            1620                1625                1630        
Ile Val Tyr Gln Glu Cys Pro Val Val Pro Ser Ser Gln Val Tyr Gln
        1635                1640                1645            
Cys Ile Asn Ser Cys Leu His Leu Ala Thr Trp Lys Val Gly Lys Trp
    1650                1655                1660                
Ser Lys Cys Ser Val Thr Cys Gly Ile Gly Ile Met Lys Arg Gln Val
1665                1670                1675                1680
Lys Cys Ile Thr Lys His Gly Leu Ser Ser Asp Leu Cys Leu Asn His
                1685                1690                1695    
Leu Lys Pro Gly Ala Gln Lys Lys Cys Tyr Ala Asn Asp Cys Lys Ser
            1700                1705                1710        
Phe Thr Thr Cys Lys Glu Ile Gln Val Lys Asn His Ile Arg Lys Asp
        1715                1720                1725            
Gly Asp Tyr Tyr Leu Asn Ile Lys Gly Arg Ile Ile Lys Ile Tyr Cys
    1730                1735                1740                
Ala Asp Met Tyr Leu Glu Asn Pro Lys Glu Tyr Leu Thr Leu Val Gln
1745                1750                1755                1760
Gly Glu Glu Asn Phe Ser Glu Val Tyr Gly Phe Arg Leu Lys Asn Pro
                1765                1770                1775    
Tyr Gln Cys Pro Phe Asn Gly Ser Arg Arg Glu Asp Cys Glu Cys Asp
            1780                1785                1790        
Asn Gly His Leu Ala Ala Gly Tyr Thr Val Phe Ser Lys Ile Arg Ile
        1795                1800                1805            
Asp Leu Thr Ser Met Gln Ile Lys Thr Thr Asp Leu Leu Phe Ser Lys
    1810                1815                1820                
Thr Ile Phe Gly Asn Ala Val Pro Phe Ala Thr Ala Gly Asp Cys Tyr
1825                1830                1835                1840
Ser Ala Phe Arg Cys Pro Gln Gly Gln Phe Ser Ile Asn Leu Ser Gly
                1845                1850                1855    
Thr Gly Met Lys Ile Ser Ser Thr Ala Lys Trp Leu Thr Gln Gly Ser
            1860                1865                1870        
Tyr Thr Ser Val Ser Ile Arg Arg Ser Glu Asp Gly Thr Arg Phe Phe
        1875                1880                1885            
Gly Lys Cys Gly Gly Tyr Cys Gly Lys Cys Leu Pro His Met Thr Thr
    1890                1895                1900                
Gly Leu Pro Ile Gln Val Ile
1905                1910    


<210> 9036
<211> 454
<212> PRT
<213> Homo sapiens

<400> 9036
Met Leu Arg Ile Leu Cys Leu Ala Leu Cys Ser Leu Leu Thr Gly Thr
 1               5                  10                  15      
Arg Ala Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn
            20                  25                  30          
Arg Glu Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met
        35                  40                  45              
Ala Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly
    50                  55                  60                  
Ile Thr Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu
65                  70                  75                  80  
Asn Phe Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met
                85                  90                  95      
Thr Val Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val
            100                 105                 110         
Ala Leu Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr
        115                 120                 125             
Gly Leu Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn
    130                 135                 140                 
Val Lys Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys
145                 150                 155                 160 
Phe Leu Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro
                165                 170                 175     
Ala Ile Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu
            180                 185                 190         
Ser Asp Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu
        195                 200                 205             
Met Ser Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser
    210                 215                 220                 
Pro Val Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala
225                 230                 235                 240 
Gly Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln
                245                 250                 255     
Leu Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln
            260                 265                 270         
Lys Ser Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro
        275                 280                 285             
Pro Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val
    290                 295                 300                 
Ala Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys
305                 310                 315                 320 
Pro Pro Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His
                325                 330                 335     
Ser Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met
            340                 345                 350         
Ser Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser
        355                 360                 365             
Val His Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Leu Leu
    370                 375                 380                 
Ser Leu Ser Arg Lys Ser Ser Ser Ile Gly Asn Phe Asn Glu Arg Glu
385                 390                 395                 400 
Leu Thr Gly Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val
                405                 410                 415     
Val Asn Asp Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala
            420                 425                 430         
Met Asn Tyr Asn Leu Ala Glu Leu Asp Ile Val Glu Asn Ala Leu Met
        435                 440                 445             
Leu Asp Leu Lys Leu Gly
    450                 


<210> 9037
<211> 484
<212> PRT
<213> Homo sapiens

<400> 9037
Met Ala Gly Pro Trp Thr Phe Thr Leu Leu Cys Gly Leu Leu Ala Ala
 1               5                  10                  15      
Thr Leu Ile Gln Ala Thr Leu Ser Pro Thr Ala Val Leu Ile Leu Gly
            20                  25                  30          
Pro Lys Val Ile Lys Glu Lys Leu Thr Gln Glu Leu Lys Asp His Asn
        35                  40                  45              
Ala Thr Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu
    50                  55                  60                  
Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Thr Val
65                  70                  75                  80  
Leu Lys His Ile Ile Trp Leu Lys Val Ile Thr Ala Asn Ile Leu Gln
                85                  90                  95      
Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile
            100                 105                 110         
Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys Thr Ile
        115                 120                 125             
Val Glu Phe His Met Thr Thr Glu Ala Gln Ala Thr Ile Arg Met Asp
    130                 135                 140                 
Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys Ala Thr
145                 150                 155                 160 
Ser His Gly Ser Leu Arg Ile Gln Leu Leu His Lys Leu Ser Phe Leu
                165                 170                 175     
Val Asn Ala Leu Ala Lys Gln Val Met Asn Leu Leu Val Pro Ser Leu
            180                 185                 190         
Pro Asn Leu Val Lys Asn Gln Leu Cys Pro Val Ile Glu Ala Ser Phe
        195                 200                 205             
Asn Gly Met Tyr Ala Asp Leu Leu Gln Leu Val Lys Val Pro Ile Ser
    210                 215                 220                 
Leu Ser Ile Asp Arg Leu Glu Phe Asp Leu Leu Tyr Pro Ala Ile Lys
225                 230                 235                 240 
Gly Asp Thr Ile Gln Leu Tyr Leu Gly Ala Lys Leu Leu Asp Ser Gln
                245                 250                 255     
Gly Lys Val Thr Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Thr Met
            260                 265                 270         
Pro Thr Leu Asp Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val
        275                 280                 285             
Val Lys Ala Ala Val Ala Ala Val Leu Ser Pro Glu Glu Phe Met Val
    290                 295                 300                 
Leu Leu Asp Ser Val Leu Pro Glu Ser Ala His Arg Leu Lys Ser Ser
305                 310                 315                 320 
Ile Gly Leu Ile Asn Glu Lys Ala Ala Asp Lys Leu Gly Ser Thr Gln
                325                 330                 335     
Ile Val Lys Ile Leu Thr Gln Asp Thr Pro Glu Phe Phe Ile Asp Gln
            340                 345                 350         
Gly His Ala Lys Val Ala Gln Leu Ile Val Leu Glu Val Phe Pro Ser
        355                 360                 365             
Ser Glu Ala Leu Arg Pro Leu Phe Thr Leu Gly Ile Glu Ala Ser Ser
    370                 375                 380                 
Glu Ala Gln Phe Tyr Thr Lys Gly Asp Gln Leu Ile Leu Asn Leu Asn
385                 390                 395                 400 
Asn Ile Ser Ser Asp Arg Ile Gln Leu Met Asn Ser Gly Ile Gly Trp
                405                 410                 415     
Phe Gln Pro Asp Val Leu Lys Asn Ile Ile Thr Glu Ile Ile His Ser
            420                 425                 430         
Ile Leu Leu Pro Asn Gln Asn Gly Lys Leu Arg Ser Gly Val Pro Val
        435                 440                 445             
Ser Leu Val Lys Ala Leu Gly Phe Glu Ala Ala Glu Ser Ser Leu Thr
    450                 455                 460                 
Lys Asp Ala Leu Val Leu Thr Pro Ala Ser Leu Trp Lys Pro Ser Ser
465                 470                 475                 480 
Pro Val Ser Gln
                


<210> 9038
<211> 352
<212> PRT
<213> Homo sapiens

<400> 9038
Met Ala Gly Thr Ile Cys Phe Ile Met Trp Val Leu Phe Ile Thr Asp
 1               5                  10                  15      
Thr Val Trp Ser Arg Ser Val Arg Gln Val Tyr Glu Val His Asp Ser
            20                  25                  30          
Asp Asp Trp Thr Ile His Asp Phe Glu Cys Pro Met Glu Cys Phe Cys
        35                  40                  45              
Pro Pro Ser Phe Pro Thr Ala Leu Tyr Cys Glu Asn Arg Gly Leu Lys
    50                  55                  60                  
Glu Ile Pro Ala Ile Pro Ser Arg Ile Trp Tyr Leu Tyr Leu Gln Asn
65                  70                  75                  80  
Asn Leu Ile Glu Thr Ile Pro Glu Lys Pro Phe Glu Asn Ala Thr Gln
                85                  90                  95      
Leu Arg Trp Ile Asn Leu Asn Lys Asn Lys Ile Thr Asn Tyr Gly Ile
            100                 105                 110         
Glu Lys Gly Ala Leu Ser Gln Leu Lys Lys Leu Leu Phe Leu Phe Leu
        115                 120                 125             
Glu Asp Asn Glu Leu Glu Glu Val Pro Ser Pro Leu Pro Arg Ser Leu
    130                 135                 140                 
Glu Gln Leu Gln Leu Ala Arg Asn Lys Val Ser Arg Ile Pro Gln Gly
145                 150                 155                 160 
Thr Phe Ser Asn Leu Glu Asn Leu Thr Leu Leu Asp Leu Gln Asn Asn
                165                 170                 175     
Lys Leu Val Asp Asn Ala Phe Gln Arg Asp Thr Phe Lys Gly Leu Lys
            180                 185                 190         
Asn Leu Met Gln Leu Asn Met Ala Lys Asn Ala Leu Arg Asn Met Pro
        195                 200                 205             
Pro Arg Leu Pro Ala Asn Thr Met Gln Leu Phe Leu Asp Asn Asn Ser
    210                 215                 220                 
Ile Glu Gly Ile Pro Glu Asn Tyr Phe Asn Val Ile Pro Lys Val Ala
225                 230                 235                 240 
Phe Leu Arg Leu Asn His Asn Lys Leu Ser Asp Glu Gly Leu Pro Ser
                245                 250                 255     
Arg Gly Phe Asp Val Ser Ser Ile Leu Asp Leu Gln Leu Ser His Asn
            260                 265                 270         
Gln Leu Thr Lys Val Pro Arg Ile Ser Ala His Leu Gln His Leu His
        275                 280                 285             
Leu Asp His Asn Lys Ile Lys Ser Val Asn Val Ser Val Ile Cys Pro
    290                 295                 300                 
Ser Pro Ser Met Leu Pro Ala Glu Arg Asp Ser Phe Ser Tyr Gly Pro
305                 310                 315                 320 
His Leu Arg Tyr Leu Arg Leu Asp Gly Asn Glu Ile Lys Pro Pro Ile
                325                 330                 335     
Pro Met Ala Leu Met Thr Cys Phe Arg Leu Leu Gln Ala Val Ile Ile
            340                 345                 350         


<210> 9039
<211> 325
<212> PRT
<213> Homo sapiens

<400> 9039
Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro
 1               5                  10                  15      
Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly
            20                  25                  30          
Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met
        35                  40                  45              
Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp
    50                  55                  60                  
Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp
65                  70                  75                  80  
Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp
                85                  90                  95      
Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp
            100                 105                 110         
His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys
        115                 120                 125             
Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro
    130                 135                 140                 
Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu
145                 150                 155                 160 
Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg
                165                 170                 175     
Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu
            180                 185                 190         
Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val
        195                 200                 205             
Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu
    210                 215                 220                 
Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His
225                 230                 235                 240 
Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val
                245                 250                 255     
Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg
            260                 265                 270         
Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser
        275                 280                 285             
Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val
    290                 295                 300                 
Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro
305                 310                 315                 320 
Arg Arg Ala Arg Pro
                325 


<210> 9040
<211> 766
<212> PRT
<213> Homo sapiens

<400> 9040
Met Gly Arg Arg Arg Leu Leu Val Trp Leu Cys Ala Val Ala Ala Leu
 1               5                  10                  15      
Leu Ser Gly Ala Gln Ala Arg Gly Thr Pro Leu Leu Ala Arg Pro Ala
            20                  25                  30          
Pro Pro Gly Ala Ser Arg Tyr Ser Leu Tyr Thr Thr Gly Trp Arg Pro
        35                  40                  45              
Arg Leu Arg Pro Gly Pro His Lys Ala Leu Cys Ala Tyr Val Val His
    50                  55                  60                  
Arg Asn Val Thr Cys Ile Leu Gln Glu Gly Ala Glu Ser Tyr Val Lys
65                  70                  75                  80  
Ala Glu Tyr Arg Gln Cys Arg Trp Gly Pro Lys Cys Pro Gly Thr Val
                85                  90                  95      
Thr Tyr Arg Thr Val Leu Arg Pro Lys Tyr Lys Val Gly Tyr Lys Thr
            100                 105                 110         
Val Thr Asp Leu Ala Trp Arg Cys Cys Pro Gly Phe Thr Gly Lys Arg
        115                 120                 125             
Cys Pro Glu His Leu Thr Asp His Gly Ala Ala Ser Pro Gln Leu Glu
    130                 135                 140                 
Pro Glu Pro Gln Ile Pro Ser Gly Gln Leu Asp Pro Gly Pro Arg Pro
145                 150                 155                 160 
Pro Ser Tyr Ser Arg Ala Ala Pro Ser Pro His Gly Arg Lys Gly Pro
                165                 170                 175     
Gly Leu Phe Gly Glu Arg Leu Glu Arg Leu Glu Gly Asp Val Gln Arg
            180                 185                 190         
Leu Ala Gln Thr Tyr Gly Thr Leu Ser Gly Leu Val Ala Ser His Glu
        195                 200                 205             
Asp Pro Asn Arg Met Thr Gly Gly Pro Arg Ala Pro Ala Val Pro Val
    210                 215                 220                 
Gly Phe Gly Val Ile Pro Glu Gly Leu Val Gly Pro Gly Asp Arg Ala
225                 230                 235                 240 
Arg Gly Pro Leu Thr Pro Pro Leu Asp Glu Ile Leu Ser Lys Val Thr
                245                 250                 255     
Glu Val Ser Asn Thr Leu Gln Thr Lys Val Gln Leu Leu Asp Lys Val
            260                 265                 270         
His Gly Leu Ala Leu Gly His Glu Ala His Leu Gln Arg Leu Arg Glu
        275                 280                 285             
Ala Pro Pro Ser Pro Leu Thr Ser Leu Ala Leu Leu Glu Glu Tyr Val
    290                 295                 300                 
Asp Arg Arg Leu His Arg Leu Trp Gly Ser Leu Leu Asp Gly Phe Glu
305                 310                 315                 320 
Gln Lys Leu Gln Gly Val Gln Ser Glu Cys Asp Leu Arg Val Gln Glu
                325                 330                 335     
Val Arg Arg Gln Cys Glu Glu Gly Gln Ala Ala Ser Arg Arg Leu His
            340                 345                 350         
Gln Ser Leu Asp Gly Arg Glu Leu Ala Leu Arg Gln Glu Leu Ser Gln
        355                 360                 365             
Leu Gly Ser Gln Leu Gln Gly Leu Ser Val Ser Gly Arg Gly Ser Cys
    370                 375                 380                 
Cys Gly Gln Leu Ala Leu Ile Asn Ala Arg Met Asp Gly Leu Glu Arg
385                 390                 395                 400 
Ala Leu Gln Ala Val Thr Glu Thr Gln Arg Gly Pro Gly Ala Pro Ala
                405                 410                 415     
Gly Asp Glu Leu Thr Arg Leu Ser Ala Ala Met Leu Glu Gly Gly Val
            420                 425                 430         
Asp Gly Leu Leu Glu Gly Leu Glu Thr Leu Asn Gly Thr Glu Gly Gly
        435                 440                 445             
Ala Arg Gly Cys Cys Leu Arg Leu Asp Met Gly Gly Trp Gly Val Gly
    450                 455                 460                 
Gly Phe Gly Thr Met Leu Glu Glu Arg Val Gln Ser Leu Glu Glu Arg
465                 470                 475                 480 
Leu Ala Thr Leu Ala Gly Glu Leu Ser His Asp Ser Ala Ser Pro Gly
                485                 490                 495     
Arg Ser Ala Arg Pro Leu Val Gln Thr Glu Leu Ala Val Leu Glu Gln
            500                 505                 510         
Arg Leu Val Ser Leu Glu Thr Ser Cys Thr Pro Ser Thr Thr Ser Ala
        515                 520                 525             
Ile Leu Asp Ser Leu Val Ala Glu Val Lys Ala Trp Gln Ser Arg Ser
    530                 535                 540                 
Glu Ala Leu Leu Arg Gln Val Ala Ser His Ala Ala Leu Leu Gln Gln
545                 550                 555                 560 
Leu Asn Gly Thr Val Ala Glu Val Gln Gly Gln Leu Ala Glu Gly Thr
                565                 570                 575     
Gly Ser Ser Leu Gln Gly Glu Ile Thr Leu Leu Lys Val Asn Leu Asn
            580                 585                 590         
Ser Val Ser Lys Ser Leu Thr Gly Leu Ser Asp Ser Val Ser Gln Tyr
        595                 600                 605             
Ser Asp Ala Phe Leu Ala Ala Asn Thr Ser Leu Asp Glu Arg Glu Arg
    610                 615                 620                 
Lys Val Glu Ala Glu Val Gln Ala Ile Gln Glu Gln Val Ser Ser Gln
625                 630                 635                 640 
Gly Ser Arg Leu Gln Ala Gly His Arg Gln Val Leu Asn Leu Arg Gly
                645                 650                 655     
Glu Leu Glu Gln Leu Lys Ala Gly Val Ala Lys Val Ala Ser Gly Leu
            660                 665                 670         
Ser Arg Cys Gln Asp Thr Ala Gln Lys Leu Gln His Thr Val Gly His
        675                 680                 685             
Phe Asp Gln Arg Val Ala Gln Val Glu Gly Ala Cys Arg Arg Leu Gly
    690                 695                 700                 
Leu Leu Ala Ala Gly Leu Asp Ser Leu Pro Thr Glu Pro Leu Arg Pro
705                 710                 715                 720 
Arg Glu Gly Leu Trp Ser His Val Asp Gln Leu Asn Arg Thr Leu Ala
                725                 730                 735     
Gln His Thr Gln Asp Ile Ala Arg Leu Arg Asp Asp Leu Leu Asp Cys
            740                 745                 750         
Gln Ala Gln Leu Ala Glu Gln Val Arg Pro Gly Gln Ala Asn
        755                 760                 765     


<210> 9041
<211> 123
<212> PRT
<213> Homo sapiens

<400> 9041
Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu
 1               5                  10                  15      
Ser Ala Trp Ala His Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro
            20                  25                  30          
Gly Pro Ala Ala Thr Asp Arg Asn Pro Arg Gly Ser Ser Ser Arg Gln
        35                  40                  45              
Ser Ser Ser Ser Ala Met Ser Ser Ser Ser Ala Ser Ser Ser Pro Ala
    50                  55                  60                  
Ala Ser Leu Gly Ser Gln Gly Ser Gly Leu Glu Gln Ser Ser Phe Gln
65                  70                  75                  80  
Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly
                85                  90                  95      
Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser
            100                 105                 110         
His Glu Ala Asn Met Leu Ser Gln Val His Arg
        115                 120             


<210> 9042
<211> 815
<212> PRT
<213> Homo sapiens

<400> 9042
Met Phe Arg Leu Gly Leu Leu Val Cys Phe Tyr Asn Asp Leu Glu Leu
 1               5                  10                  15      
Leu Asp Ala Thr Val Ala Gln Val Leu Leu Tyr Gln Met Ile Lys Cys
            20                  25                  30          
Ser His Leu Arg Gly Phe Gln Ala Gly Val Gln Lys Leu Lys Ala Glu
        35                  40                  45              
Leu Leu Asp Ile Ala Met Glu Asn Gln Thr Leu Asn Glu Thr Leu Gly
    50                  55                  60                  
Ser Leu Ser Asp Ala Val Val Gly Leu Thr Tyr Ser Gln Leu Glu Ser
65                  70                  75                  80  
Leu Ser Pro Glu Ala Val His Gly Ala Ile Ser Thr Leu Asn Gln Val
                85                  90                  95      
Ser Gly Trp Ala Lys Ser Gln Val Ile Ile Leu Ser Ala Lys Tyr Leu
            100                 105                 110         
Ala His Glu Lys Val Leu Ser Phe Tyr Asn Val Ser Gln Met Gly Ala
        115                 120                 125             
Leu Leu Ala Gly Val Ser Thr Gln Ala Phe Cys Ser Met Lys Arg Lys
    130                 135                 140                 
Asp Ile Ser Gln Val Leu Arg Ser Ala Val Ser Gln Tyr Val Ser Asp
145                 150                 155                 160 
Leu Ser Pro Ala Gln Gln Gln Gly Ile Leu Ser Lys Met Val Gln Ala
                165                 170                 175     
Glu Asp Thr Ala Pro Gly Ile Val Glu Ile Gln Gly Ala Phe Phe Lys
            180                 185                 190         
Glu Val Ser Leu Phe Asp Leu Arg Arg Gln Pro Gly Phe Asn Ser Thr
        195                 200                 205             
Val Leu Lys Asp Lys Glu Leu Gly Arg Ser Gln Ala Leu Phe Leu Tyr
    210                 215                 220                 
Glu Leu Leu Leu Lys Thr Thr Arg Arg Pro Glu Glu Leu Leu Ser Ala
225                 230                 235                 240 
Gly Gln Leu Val Lys Gly Val Thr Cys Ser His Ile Asp Ala Met Ser
                245                 250                 255     
Thr Asp Phe Phe Leu Ala His Phe Gln Asp Phe Gln Asn Asn Phe Ala
            260                 265                 270         
Leu Leu Ser Pro Tyr Gln Val Asn Cys Leu Ala Trp Lys Tyr Trp Glu
        275                 280                 285             
Val Ser Arg Leu Ser Met Pro Pro Phe Leu Leu Ala Ala Leu Pro Ala
    290                 295                 300                 
Arg Tyr Leu Ala Ser Val Pro Ala Ser Gln Cys Val Pro Phe Leu Ile
305                 310                 315                 320 
Ser Leu Gly Lys Ser Trp Leu Asp Ser Leu Val Leu Asp Ser His Lys
                325                 330                 335     
Lys Thr Ser Val Leu Arg Lys Val Gln Gln Cys Leu Asp Asp Ser Ile
            340                 345                 350         
Ala Asp Glu Tyr Thr Val Asp Ile Met Gly Asn Leu Leu Cys His Leu
        355                 360                 365             
Pro Ala Ala Ile Ile Asp Arg Gly Ile Ser Pro Arg Ala Trp Ala Thr
    370                 375                 380                 
Ala Leu His Gly Leu Arg Asp Cys Pro Asp Leu Asn Pro Glu Gln Lys
385                 390                 395                 400 
Ala Ala Val Arg Leu Lys Leu Leu Gly Gln Tyr Gly Leu Pro Gln His
                405                 410                 415     
Trp Thr Ala Glu Thr Thr Lys Asp Leu Gly Pro Phe Leu Val Leu Phe
            420                 425                 430         
Ser Gly Asp Glu Leu Ser Ser Ile Ala Thr Lys Phe Pro Glu Ile Leu
        435                 440                 445             
Leu Gln Ala Ala Ser Lys Met Ala Arg Thr Leu Pro Thr Lys Glu Phe
    450                 455                 460                 
Leu Trp Ala Val Phe Gln Ser Val Arg Asn Ser Ser Asp Lys Ile Pro
465                 470                 475                 480 
Ser Tyr Asp Pro Met Pro Gly Cys His Gly Val Val Ala Pro Ser Ser
                485                 490                 495     
Asp Asp Ile Phe Lys Leu Ala Glu Ala Asn Ala Cys Trp Ala Leu Glu
            500                 505                 510         
Asp Leu Arg Cys Met Glu Glu Asp Thr Phe Ile Arg Thr Val Glu Leu
        515                 520                 525             
Leu Gly Ala Val Gln Gly Phe Ser Arg Pro Gln Leu Met Thr Leu Lys
    530                 535                 540                 
Glu Lys Ala Ile Gln Val Trp Asp Met Pro Ser Tyr Trp Arg Glu His
545                 550                 555                 560 
His Ile Val Ser Leu Gly Arg Ile Ala Leu Ala Leu Asn Glu Ser Glu
                565                 570                 575     
Leu Glu Gln Leu Asp Leu Ser Ser Ile Asp Thr Val Ala Ser Leu Ser
            580                 585                 590         
Trp Gln Thr Glu Trp Thr Pro Gly Gln Ala Glu Ser Ile Leu Gln Gly
        595                 600                 605             
Tyr Leu Asp Asp Ser Gly Tyr Ser Ile Gln Asp Leu Lys Ser Phe His
    610                 615                 620                 
Leu Val Gly Leu Gly Ala Thr Leu Cys Ala Ile Asn Ile Thr Glu Ile
625                 630                 635                 640 
Pro Leu Ile Lys Ile Ser Glu Phe Arg Val Val Val Ala Arg Ile Gly
                645                 650                 655     
Thr Leu Leu Cys Ser Thr His Val Leu Ala Glu Phe Lys Arg Lys Ala
            660                 665                 670         
Glu Val Val Phe Gly Asp Pro Thr Glu Trp Thr Ser Ser Val Leu Gln
        675                 680                 685             
Glu Leu Gly Thr Ile Ala Ala Gly Leu Thr Lys Ala Glu Leu Arg Met
    690                 695                 700                 
Leu Asp Lys Asp Leu Met Pro Tyr Phe Gln Pro Ser Ala Ile Lys Cys
705                 710                 715                 720 
Leu Pro Asp Glu Ile Phe Lys Glu Leu Ser Ala Glu Gln Ile Ala Ser
                725                 730                 735     
Leu Gly Pro Glu Asn Ala Ala Ala Val Thr His Ala Gln Arg Arg Arg
            740                 745                 750         
Leu Ser Pro Leu Gln Leu Gln Ser Leu Gln Gln Ala Leu Asp Gly Ala
        755                 760                 765             
Lys Thr His Ser Trp Gln Asp Ala Pro Ala Ser Ala Gly Pro Thr Arg
    770                 775                 780                 
Thr Ser Ser Ser Arg Ser Pro Ala Gly Ala Leu Gln Ser Trp Gly Leu
785                 790                 795                 800 
Trp Leu Gly Cys Pro Leu Leu Val Leu Met Ala Lys Leu Leu Trp
                805                 810                 815 


<210> 9043
<211> 1153
<212> PRT
<213> Homo sapiens

<400> 9043
Met Ser Gln Glu Pro Thr Thr Tyr Ser Leu Phe Leu Phe Leu Phe Leu
 1               5                  10                  15      
Ser His Gly Val Ser Ser Tyr Thr Val Pro Asn Ser Arg Gln Asp Leu
            20                  25                  30          
His Pro Leu Leu Gln Asn Met Ala Glu Glu Ile Ile Asp Gly Ser Tyr
        35                  40                  45              
Leu Asn Ala Leu Leu Asp Leu Ile Gln Phe Gln Ser Ser His Val Trp
    50                  55                  60                  
Thr Asp Asp Leu Ser His Arg Val Leu Ala Tyr Leu Asn Ser Arg Asn
65                  70                  75                  80  
Val Ala Phe Thr Ile Pro Ser Leu Gln Ala Ala Val Glu Asn His Leu
                85                  90                  95      
Glu Gln Arg Leu His Gln Pro Gln Lys Leu Leu Glu Asp Leu Arg Lys
            100                 105                 110         
Thr Asp Ala Gln Gln Phe Arg Thr Ala Met Lys Cys Leu Leu Glu Asp
        115                 120                 125             
Lys Lys Asp Gly Leu Asp Leu Lys Asp Ile Ile Ile Asp Leu Gly Glu
    130                 135                 140                 
Ile Arg Glu Arg Ala Leu Gln Ser Pro Gly Val Asn Arg Ser Leu Phe
145                 150                 155                 160 
Leu Ile Thr Leu Glu Arg Cys Phe Gln Met Leu Asn Ser Leu Glu Cys
                165                 170                 175     
Val Glu Ile Leu Gly Lys Val Leu Arg Gly Ser Ser Gly Ser Phe Leu
            180                 185                 190         
Gln Pro Asp Ile Thr Glu Arg Leu Pro Arg Asp Leu Arg Glu Asp Ala
        195                 200                 205             
Phe Lys Asn Leu Ser Ala Val Phe Lys Asp Leu Tyr Asp Lys Thr Ser
    210                 215                 220                 
Ala His Ser Gln Arg Ala Leu Tyr Ser Trp Met Thr Gly Ile Leu Gln
225                 230                 235                 240 
Thr Ser Ser Asn Ala Thr Asp Asp Ser Ala Ser Trp Val Ser Ala Glu
                245                 250                 255     
His Leu Trp Val Leu Gly Arg Tyr Met Val His Leu Ser Phe Glu Glu
            260                 265                 270         
Ile Thr Lys Ile Ser Pro Ile Glu Ile Gly Leu Phe Ile Ser Tyr Asp
        275                 280                 285             
Asn Ala Thr Lys Gln Leu Asp Met Val Tyr Asp Ile Thr Pro Glu Leu
    290                 295                 300                 
Ala Gln Ala Phe Leu Glu Arg Ile Ser Ser Ser Asn Phe Asn Met Arg
305                 310                 315                 320 
Asn Thr Ser Thr Ile His Arg Gln Ala His Glu Leu Trp Ala Leu Glu
                325                 330                 335     
Pro Phe Pro Lys Met Leu Gly Leu Leu Val Cys Phe Tyr Asn Asp Leu
            340                 345                 350         
Glu Leu Leu Asp Ala Thr Val Ala Gln Val Leu Leu Tyr Gln Met Ile
        355                 360                 365             
Lys Cys Ser His Leu Arg Gly Phe Gln Ala Gly Val Gln Lys Leu Lys
    370                 375                 380                 
Ala Glu Leu Leu Asp Ile Ala Met Glu Asn Gln Thr Leu Asn Glu Thr
385                 390                 395                 400 
Leu Gly Ser Leu Ser Asp Ala Val Val Gly Leu Thr Tyr Ser Gln Leu
                405                 410                 415     
Glu Ser Leu Ser Pro Glu Ala Val His Gly Ala Ile Ser Thr Leu Asn
            420                 425                 430         
Gln Val Ser Gly Trp Ala Lys Ser Gln Val Ile Ile Leu Ser Ala Lys
        435                 440                 445             
Tyr Leu Ala His Glu Lys Val Leu Ser Phe Tyr Asn Val Ser Gln Met
    450                 455                 460                 
Gly Ala Leu Leu Ala Gly Val Ser Thr Gln Ala Phe Cys Ser Met Lys
465                 470                 475                 480 
Arg Lys Asp Ile Ser Gln Val Leu Arg Ser Ala Val Ser Gln Tyr Val
                485                 490                 495     
Ser Asp Leu Ser Pro Ala Gln Gln Gln Gly Ile Leu Ser Lys Met Val
            500                 505                 510         
Gln Ala Glu Asp Thr Ala Pro Gly Ile Val Glu Ile Gln Gly Ala Phe
        515                 520                 525             
Phe Lys Glu Val Ser Leu Phe Asp Leu Arg Arg Gln Pro Gly Phe Asn
    530                 535                 540                 
Ser Thr Val Leu Lys Asp Lys Glu Leu Gly Arg Ser Gln Ala Leu Phe
545                 550                 555                 560 
Leu Tyr Glu Leu Leu Leu Lys Thr Thr Arg Arg Pro Glu Glu Leu Leu
                565                 570                 575     
Ser Ala Gly Gln Leu Val Lys Gly Val Thr Cys Ser His Ile Asp Ala
            580                 585                 590         
Met Ser Thr Asp Phe Phe Leu Ala His Phe Gln Asp Phe Gln Asn Asn
        595                 600                 605             
Phe Ala Leu Leu Ser Pro Tyr Gln Val Asn Cys Leu Ala Trp Lys Tyr
    610                 615                 620                 
Trp Glu Val Ser Arg Leu Ser Met Pro Pro Phe Leu Leu Ala Ala Leu
625                 630                 635                 640 
Pro Ala Arg Tyr Leu Ala Ser Val Pro Ala Ser Gln Cys Val Pro Phe
                645                 650                 655     
Leu Ile Ser Leu Gly Lys Ser Trp Leu Asp Ser Leu Val Leu Asp Ser
            660                 665                 670         
His Lys Lys Thr Ser Val Leu Arg Lys Val Gln Gln Cys Leu Asp Asp
        675                 680                 685             
Ser Ile Ala Asp Glu Tyr Thr Val Asp Ile Met Gly Asn Leu Leu Cys
    690                 695                 700                 
His Leu Pro Ala Ala Ile Ile Asp Arg Gly Ile Ser Pro Arg Ala Trp
705                 710                 715                 720 
Ala Thr Ala Leu His Gly Leu Arg Asp Cys Pro Asp Leu Asn Pro Glu
                725                 730                 735     
Gln Lys Ala Ala Val Arg Leu Lys Leu Leu Gly Gln Tyr Gly Leu Pro
            740                 745                 750         
Gln His Trp Thr Ala Glu Thr Thr Lys Asp Leu Gly Pro Phe Leu Val
        755                 760                 765             
Leu Phe Ser Gly Asp Glu Leu Ser Ser Ile Ala Thr Lys Phe Pro Glu
    770                 775                 780                 
Ile Leu Leu Gln Ala Ala Ser Lys Met Ala Arg Thr Leu Pro Thr Lys
785                 790                 795                 800 
Glu Phe Leu Trp Ala Val Phe Gln Ser Val Arg Asn Ser Ser Asp Lys
                805                 810                 815     
Ile Pro Ser Tyr Asp Pro Met Pro Gly Cys His Gly Val Val Ala Pro
            820                 825                 830         
Ser Ser Asp Asp Ile Phe Lys Leu Ala Glu Ala Asn Ala Cys Trp Ala
        835                 840                 845             
Leu Glu Asp Leu Arg Cys Met Glu Glu Asp Thr Phe Ile Arg Thr Val
    850                 855                 860                 
Glu Leu Leu Gly Ala Val Gln Gly Phe Ser Arg Pro Gln Leu Met Thr
865                 870                 875                 880 
Leu Lys Glu Lys Ala Ile Gln Val Trp Asp Met Pro Ser Tyr Trp Arg
                885                 890                 895     
Glu His His Ile Val Ser Leu Gly Arg Ile Ala Leu Ala Leu Asn Glu
            900                 905                 910         
Ser Glu Leu Glu Gln Leu Asp Leu Ser Ser Ile Asp Thr Val Ala Ser
        915                 920                 925             
Leu Ser Trp Gln Thr Glu Trp Thr Pro Gly Gln Ala Glu Ser Ile Leu
    930                 935                 940                 
Gln Gly Tyr Leu Asp Asp Ser Gly Tyr Ser Ile Gln Asp Leu Lys Ser
945                 950                 955                 960 
Phe His Leu Val Gly Leu Gly Ala Thr Leu Cys Ala Ile Asn Ile Thr
                965                 970                 975     
Glu Ile Pro Leu Ile Lys Ile Ser Glu Phe Arg Val Val Val Ala Arg
            980                 985                 990         
Ile Gly Thr Leu Leu Cys Ser Thr His Val Leu Ala Glu Phe Lys Arg
        995                 1000                1005            
Lys Ala Glu Val Val Phe Gly Asp Pro Thr Glu Trp Thr Ser Ser Val
    1010                1015                1020                
Leu Gln Glu Leu Gly Thr Ile Ala Ala Gly Leu Thr Lys Ala Glu Leu
1025                1030                1035                1040
Arg Met Leu Asp Lys Asp Leu Met Pro Tyr Phe Gln Pro Ser Ala Ile
                1045                1050                1055    
Lys Cys Leu Pro Asp Glu Ile Phe Lys Glu Leu Ser Ala Glu Gln Ile
            1060                1065                1070        
Ala Ser Leu Gly Pro Glu Asn Ala Ala Ala Val Thr His Ala Gln Arg
        1075                1080                1085            
Arg Arg Leu Ser Pro Leu Gln Leu Gln Ser Leu Gln Gln Ala Leu Asp
    1090                1095                1100                
Gly Ala Lys Thr His Ser Trp Gln Asp Ala Pro Ala Ser Ala Gly Pro
1105                1110                1115                1120
Thr Arg Thr Ser Ser Ser Arg Ser Pro Ala Gly Ala Leu Gln Ser Trp
                1125                1130                1135    
Gly Leu Trp Leu Gly Cys Pro Leu Leu Val Leu Met Ala Lys Leu Leu
            1140                1145                1150        
Trp
    


<210> 9044
<211> 895
<212> PRT
<213> Homo sapiens

<400> 9044
Met Ala Ala Ser Thr Gly Tyr Val Arg Leu Trp Gly Ala Ala Arg Cys
 1               5                  10                  15      
Trp Val Leu Arg Arg Pro Met Leu Ala Ala Ala Gly Gly Arg Val Pro
            20                  25                  30          
Thr Ala Ala Gly Ala Trp Leu Leu Arg Gly Pro Val Ile Thr Ala Leu
        35                  40                  45              
Thr Pro Met Thr Ile Pro Asp Val Phe Pro His Leu Pro Leu Ile Ala
    50                  55                  60                  
Ile Thr Arg Asn Pro Val Phe Pro Arg Phe Ile Lys Ile Ile Glu Val
65                  70                  75                  80  
Lys Asn Lys Lys Leu Val Glu Leu Leu Arg Arg Lys Val Arg Leu Ala
                85                  90                  95      
Gln Pro Tyr Val Gly Val Phe Leu Lys Arg Asp Asp Ser Asn Glu Ser
            100                 105                 110         
Asp Val Val Glu Ser Leu Asp Glu Ile Tyr His Thr Gly Thr Phe Ala
        115                 120                 125             
Gln Ile His Glu Met Gln Asp Leu Gly Asp Lys Leu Arg Met Ile Val
    130                 135                 140                 
Met Gly His Arg Arg Val His Ile Ser Arg Gln Leu Glu Val Glu Pro
145                 150                 155                 160 
Glu Glu Pro Glu Ala Glu Asn Lys His Lys Pro Arg Arg Lys Ser Lys
                165                 170                 175     
Arg Gly Lys Lys Glu Ala Glu Asp Glu Leu Ser Ala Arg His Pro Ala
            180                 185                 190         
Glu Leu Ala Met Glu Pro Thr Pro Glu Leu Pro Ala Glu Val Leu Met
        195                 200                 205             
Val Glu Val Glu Asn Val Val His Glu Asp Phe Gln Val Thr Glu Glu
    210                 215                 220                 
Val Lys Ala Leu Thr Ala Glu Ile Val Lys Thr Ile Arg Asp Ile Ile
225                 230                 235                 240 
Ala Leu Asn Pro Leu Tyr Arg Glu Ser Val Leu Gln Met Met Gln Ala
                245                 250                 255     
Gly Gln Arg Val Val Asp Asn Pro Ile Tyr Leu Ser Asp Met Gly Ala
            260                 265                 270         
Ala Leu Thr Gly Ala Glu Ser His Glu Leu Gln Asp Val Leu Glu Glu
        275                 280                 285             
Thr Asn Ile Pro Lys Arg Leu Tyr Lys Ala Leu Ser Leu Leu Lys Lys
    290                 295                 300                 
Glu Phe Glu Leu Ser Lys Leu Gln Gln Arg Leu Gly Arg Glu Val Glu
305                 310                 315                 320 
Glu Lys Ile Lys Gln Thr His Arg Lys Tyr Leu Leu Gln Glu Gln Leu
                325                 330                 335     
Lys Ile Ile Lys Lys Glu Leu Gly Leu Glu Lys Asp Asp Lys Asp Ala
            340                 345                 350         
Ile Glu Glu Lys Phe Arg Glu Arg Leu Lys Glu Leu Val Val Pro Lys
        355                 360                 365             
His Val Met Asp Val Val Asp Glu Glu Leu Ser Lys Leu Gly Leu Leu
    370                 375                 380                 
Asp Asn His Ser Ser Glu Phe Asn Val Thr Arg Asn Tyr Leu Asp Trp
385                 390                 395                 400 
Leu Thr Ser Ile Pro Trp Gly Lys Tyr Ser Asn Glu Asn Leu Asp Leu
                405                 410                 415     
Ala Arg Ala Gln Ala Val Leu Glu Glu Asp His Tyr Gly Met Glu Asp
            420                 425                 430         
Val Lys Lys Arg Ile Leu Glu Phe Ile Ala Val Ser Gln Leu Arg Gly
        435                 440                 445             
Ser Thr Gln Gly Lys Ile Leu Cys Phe Tyr Gly Pro Pro Gly Val Gly
    450                 455                 460                 
Lys Thr Ser Ile Ala Arg Ser Ile Ala Arg Ala Leu Asn Arg Glu Tyr
465                 470                 475                 480 
Phe Arg Phe Ser Val Gly Gly Met Thr Asp Val Ala Glu Ile Lys Gly
                485                 490                 495     
His Arg Arg Thr Tyr Val Gly Ala Met Pro Gly Lys Ile Ile Gln Cys
            500                 505                 510         
Leu Lys Lys Thr Lys Thr Glu Asn Pro Leu Ile Leu Ile Asp Glu Val
        515                 520                 525             
Asp Lys Ile Gly Arg Gly Tyr Gln Gly Asp Pro Ser Ser Ala Leu Leu
    530                 535                 540                 
Glu Leu Leu Asp Pro Glu Gln Asn Ala Asn Phe Leu Asp His Tyr Leu
545                 550                 555                 560 
Asp Val Pro Val Asp Leu Ser Lys Val Leu Phe Ile Cys Thr Ala Asn
                565                 570                 575     
Val Thr Asp Thr Ile Pro Glu Pro Leu Arg Asp Arg Met Glu Met Ile
            580                 585                 590         
Asn Val Ser Gly Tyr Val Ala Gln Glu Lys Leu Ala Ile Ala Glu Arg
        595                 600                 605             
Tyr Leu Val Pro Gln Ala Arg Ala Leu Cys Gly Leu Asp Glu Ser Lys
    610                 615                 620                 
Ala Lys Leu Ser Ser Asp Val Leu Thr Leu Leu Ile Lys Gln Tyr Cys
625                 630                 635                 640 
Arg Glu Ser Gly Val Arg Asn Leu Gln Lys Gln Val Glu Lys Val Leu
                645                 650                 655     
Arg Lys Ser Ala Tyr Lys Ile Val Ser Gly Glu Ala Glu Ser Val Glu
            660                 665                 670         
Val Thr Pro Glu Asn Leu Gln Asp Phe Val Gly Lys Pro Val Phe Thr
        675                 680                 685             
Val Glu Arg Met Tyr Asp Val Thr Pro Pro Gly Val Val Met Gly Leu
    690                 695                 700                 
Ala Trp Thr Ala Met Gly Gly Ser Thr Leu Phe Val Glu Thr Ser Leu
705                 710                 715                 720 
Arg Arg Pro Gln Asp Lys Asp Ala Lys Gly Asp Lys Asp Gly Ser Leu
                725                 730                 735     
Glu Val Thr Gly Gln Leu Gly Glu Val Met Lys Glu Ser Ala Arg Ile
            740                 745                 750         
Ala Tyr Thr Phe Ala Arg Ala Phe Leu Met Gln His Ala Pro Ala Asn
        755                 760                 765             
Asp Tyr Leu Val Thr Ser His Ile His Leu His Val Pro Glu Gly Ala
    770                 775                 780                 
Thr Pro Lys Asp Gly Pro Ser Ala Gly Cys Thr Ile Val Thr Ala Leu
785                 790                 795                 800 
Leu Ser Leu Ala Met Gly Arg Pro Val Arg Gln Asn Leu Ala Met Thr
                805                 810                 815     
Gly Glu Val Ser Leu Thr Gly Lys Ile Leu Pro Val Gly Gly Ile Lys
            820                 825                 830         
Glu Lys Thr Ile Ala Ala Lys Arg Ala Gly Val Thr Cys Ile Val Leu
        835                 840                 845             
Pro Ala Glu Asn Lys Lys Asp Phe Tyr Asp Leu Ala Ala Phe Ile Thr
    850                 855                 860                 
Glu Gly Leu Glu Val His Phe Val Glu His Tyr Arg Glu Ile Phe Asp
865                 870                 875                 880 
Ile Ala Phe Pro Asp Glu Gln Ala Glu Ala Leu Ala Val Glu Arg
                885                 890                 895 


<210> 9045
<211> 959
<212> PRT
<213> Homo sapiens

<400> 9045
Met Ala Ala Ser Thr Gly Tyr Val Arg Leu Trp Gly Ala Ala Arg Cys
 1               5                  10                  15      
Trp Val Leu Arg Arg Pro Met Leu Ala Ala Ala Gly Gly Arg Val Pro
            20                  25                  30          
Thr Ala Ala Gly Ala Trp Leu Leu Arg Gly Gln Arg Thr Cys Asp Ala
        35                  40                  45              
Ser Pro Pro Trp Ala Leu Trp Gly Arg Gly Pro Ala Ile Gly Gly Gln
    50                  55                  60                  
Trp Arg Gly Phe Trp Glu Ala Ser Ser Arg Gly Gly Gly Ala Phe Ser
65                  70                  75                  80  
Gly Gly Glu Asp Ala Ser Glu Gly Gly Ala Glu Glu Gly Ala Gly Gly
                85                  90                  95      
Ala Gly Gly Ser Ala Gly Ala Gly Glu Gly Pro Val Ile Thr Ala Leu
            100                 105                 110         
Thr Pro Met Thr Ile Pro Asp Val Phe Pro His Leu Pro Leu Ile Ala
        115                 120                 125             
Ile Thr Arg Asn Pro Val Phe Pro Arg Phe Ile Lys Ile Ile Glu Val
    130                 135                 140                 
Lys Asn Lys Lys Leu Val Glu Leu Leu Arg Arg Lys Val Arg Leu Ala
145                 150                 155                 160 
Gln Pro Tyr Val Gly Val Phe Leu Lys Arg Asp Asp Ser Asn Glu Ser
                165                 170                 175     
Asp Val Val Glu Ser Leu Asp Glu Ile Tyr His Thr Gly Thr Phe Ala
            180                 185                 190         
Gln Ile His Glu Met Gln Asp Leu Gly Asp Lys Leu Arg Met Ile Val
        195                 200                 205             
Met Gly His Arg Arg Val His Ile Ser Arg Gln Leu Glu Val Glu Pro
    210                 215                 220                 
Glu Glu Pro Glu Ala Glu Asn Lys His Lys Pro Arg Arg Lys Ser Lys
225                 230                 235                 240 
Arg Gly Lys Lys Glu Ala Glu Asp Glu Leu Ser Ala Arg His Pro Ala
                245                 250                 255     
Glu Leu Ala Met Glu Pro Thr Pro Glu Leu Pro Ala Glu Val Leu Met
            260                 265                 270         
Val Glu Val Glu Asn Val Val His Glu Asp Phe Gln Val Thr Glu Glu
        275                 280                 285             
Val Lys Ala Leu Thr Ala Glu Ile Val Lys Thr Ile Arg Asp Ile Ile
    290                 295                 300                 
Ala Leu Asn Pro Leu Tyr Arg Glu Ser Val Leu Gln Met Met Gln Ala
305                 310                 315                 320 
Gly Gln Arg Val Val Asp Asn Pro Ile Tyr Leu Ser Asp Met Gly Ala
                325                 330                 335     
Ala Leu Thr Gly Ala Glu Ser His Glu Leu Gln Asp Val Leu Glu Glu
            340                 345                 350         
Thr Asn Ile Pro Lys Arg Leu Tyr Lys Ala Leu Ser Leu Leu Lys Lys
        355                 360                 365             
Glu Phe Glu Leu Ser Lys Leu Gln Gln Arg Leu Gly Arg Glu Val Glu
    370                 375                 380                 
Glu Lys Ile Lys Gln Thr His Arg Lys Tyr Leu Leu Gln Glu Gln Leu
385                 390                 395                 400 
Lys Ile Ile Lys Lys Glu Leu Gly Leu Glu Lys Asp Asp Lys Asp Ala
                405                 410                 415     
Ile Glu Glu Lys Phe Arg Glu Arg Leu Lys Glu Leu Val Val Pro Lys
            420                 425                 430         
His Val Met Asp Val Val Asp Glu Glu Leu Ser Lys Leu Gly Leu Leu
        435                 440                 445             
Asp Asn His Ser Ser Glu Phe Asn Val Thr Arg Asn Tyr Leu Asp Trp
    450                 455                 460                 
Leu Thr Ser Ile Pro Trp Gly Lys Tyr Ser Asn Glu Asn Leu Asp Leu
465                 470                 475                 480 
Ala Arg Ala Gln Ala Val Leu Glu Glu Asp His Tyr Gly Met Glu Asp
                485                 490                 495     
Val Lys Lys Arg Ile Leu Glu Phe Ile Ala Val Ser Gln Leu Arg Gly
            500                 505                 510         
Ser Thr Gln Gly Lys Ile Leu Cys Phe Tyr Gly Pro Pro Gly Val Gly
        515                 520                 525             
Lys Thr Ser Ile Ala Arg Ser Ile Ala Arg Ala Leu Asn Arg Glu Tyr
    530                 535                 540                 
Phe Arg Phe Ser Val Gly Gly Met Thr Asp Val Ala Glu Ile Lys Gly
545                 550                 555                 560 
His Arg Arg Thr Tyr Val Gly Ala Met Pro Gly Lys Ile Ile Gln Cys
                565                 570                 575     
Leu Lys Lys Thr Lys Thr Glu Asn Pro Leu Ile Leu Ile Asp Glu Val
            580                 585                 590         
Asp Lys Ile Gly Arg Gly Tyr Gln Gly Asp Pro Ser Ser Ala Leu Leu
        595                 600                 605             
Glu Leu Leu Asp Pro Glu Gln Asn Ala Asn Phe Leu Asp His Tyr Leu
    610                 615                 620                 
Asp Val Pro Val Asp Leu Ser Lys Val Leu Phe Ile Cys Thr Ala Asn
625                 630                 635                 640 
Val Thr Asp Thr Ile Pro Glu Pro Leu Arg Asp Arg Met Glu Met Ile
                645                 650                 655     
Asn Val Ser Gly Tyr Val Ala Gln Glu Lys Leu Ala Ile Ala Glu Arg
            660                 665                 670         
Tyr Leu Val Pro Gln Ala Arg Ala Leu Cys Gly Leu Asp Glu Ser Lys
        675                 680                 685             
Ala Lys Leu Ser Ser Asp Val Leu Thr Leu Leu Ile Lys Gln Tyr Cys
    690                 695                 700                 
Arg Glu Ser Gly Val Arg Asn Leu Gln Lys Gln Val Glu Lys Val Leu
705                 710                 715                 720 
Arg Lys Ser Ala Tyr Lys Ile Val Ser Gly Glu Ala Glu Ser Val Glu
                725                 730                 735     
Val Thr Pro Glu Asn Leu Gln Asp Phe Val Gly Lys Pro Val Phe Thr
            740                 745                 750         
Val Glu Arg Met Tyr Asp Val Thr Pro Pro Gly Val Val Met Gly Leu
        755                 760                 765             
Ala Trp Thr Ala Met Gly Gly Ser Thr Leu Phe Val Glu Thr Ser Leu
    770                 775                 780                 
Arg Arg Pro Gln Asp Lys Asp Ala Lys Gly Asp Lys Asp Gly Ser Leu
785                 790                 795                 800 
Glu Val Thr Gly Gln Leu Gly Glu Val Met Lys Glu Ser Ala Arg Ile
                805                 810                 815     
Ala Tyr Thr Phe Ala Arg Ala Phe Leu Met Gln His Ala Pro Ala Asn
            820                 825                 830         
Asp Tyr Leu Val Thr Ser His Ile His Leu His Val Pro Glu Gly Ala
        835                 840                 845             
Thr Pro Lys Asp Gly Pro Ser Ala Gly Cys Thr Ile Val Thr Ala Leu
    850                 855                 860                 
Leu Ser Leu Ala Met Gly Arg Pro Val Arg Gln Asn Leu Ala Met Thr
865                 870                 875                 880 
Gly Glu Val Ser Leu Thr Gly Lys Ile Leu Pro Val Gly Gly Ile Lys
                885                 890                 895     
Glu Lys Thr Ile Ala Ala Lys Arg Ala Gly Val Thr Cys Ile Val Leu
            900                 905                 910         
Pro Ala Glu Asn Lys Lys Asp Phe Tyr Asp Leu Ala Ala Phe Ile Thr
        915                 920                 925             
Glu Gly Leu Glu Val His Phe Val Glu His Tyr Arg Glu Ile Phe Asp
    930                 935                 940                 
Ile Ala Phe Pro Asp Glu Gln Ala Glu Ala Leu Ala Val Glu Arg
945                 950                 955                 


<210> 9046
<211> 477
<212> PRT
<213> Homo sapiens

<400> 9046
Met Gln Pro Val Met Leu Ala Leu Trp Ser Leu Leu Leu Leu Trp Gly
 1               5                  10                  15      
Leu Ala Thr Pro Tyr Cys Gln Glu Leu Leu Glu Thr Val Gly Thr Leu
            20                  25                  30          
Ala Arg Ile Asp Lys Asp Glu Leu Gly Lys Ala Ile Gln Asn Ser Leu
        35                  40                  45              
Val Gly Glu Pro Ile Leu Gln Asn Val Leu Gly Ser Val Thr Ala Val
    50                  55                  60                  
Asn Arg Gly Leu Leu Gly Ser Gly Gly Leu Leu Gly Gly Gly Gly Leu
65                  70                  75                  80  
Leu Gly His Gly Gly Val Phe Gly Val Val Glu Glu Leu Ser Gly Leu
                85                  90                  95      
Lys Ile Glu Glu Leu Thr Leu Pro Lys Val Leu Leu Lys Leu Leu Pro
            100                 105                 110         
Gly Phe Gly Val Gln Leu Ser Leu His Thr Lys Val Gly Met His Cys
        115                 120                 125             
Ser Gly Pro Leu Gly Gly Leu Leu Gln Leu Ala Ala Glu Val Asn Val
    130                 135                 140                 
Thr Ser Arg Val Ala Leu Ala Val Ser Ser Arg Gly Thr Pro Ile Leu
145                 150                 155                 160 
Ile Leu Lys Arg Cys Ser Thr Leu Leu Gly His Ile Ser Leu Phe Ser
                165                 170                 175     
Gly Leu Leu Pro Thr Pro Leu Phe Gly Val Val Glu Gln Met Leu Phe
            180                 185                 190         
Lys Val Leu Pro Gly Leu Leu Cys Pro Val Val Asp Ser Val Leu Gly
        195                 200                 205             
Val Val Asn Glu Leu Leu Gly Ala Val Leu Gly Leu Val Ser Leu Gly
    210                 215                 220                 
Ala Leu Gly Ser Val Glu Phe Ser Leu Ala Thr Leu Pro Leu Ile Ser
225                 230                 235                 240 
Asn Gln Tyr Ile Glu Leu Asp Ile Asn Pro Ile Val Lys Ser Val Ala
                245                 250                 255     
Gly Asp Ile Ile Asp Phe Pro Lys Ser Arg Ala Pro Ala Lys Val Pro
            260                 265                 270         
Pro Lys Lys Asp His Thr Ser Gln Val Met Val Pro Leu Tyr Leu Phe
        275                 280                 285             
Asn Thr Thr Phe Gly Leu Leu Gln Thr Asn Gly Ala Leu Asp Met Asp
    290                 295                 300                 
Ile Thr Pro Glu Leu Val Pro Ser Asp Val Pro Leu Thr Thr Thr Asp
305                 310                 315                 320 
Leu Ala Ala Leu Leu Pro Glu Ala Leu Gly Lys Leu Pro Leu His Gln
                325                 330                 335     
Gln Leu Leu Leu Phe Leu Arg Val Arg Glu Ala Pro Thr Val Thr Leu
            340                 345                 350         
His Asn Lys Lys Ala Leu Val Ser Leu Pro Ala Asn Ile His Val Leu
        355                 360                 365             
Phe Tyr Val Pro Lys Gly Thr Pro Glu Ser Leu Phe Glu Leu Asn Ser
    370                 375                 380                 
Val Met Thr Val Arg Ala Gln Leu Ala Pro Ser Ala Thr Lys Leu His
385                 390                 395                 400 
Ile Ser Leu Ser Leu Glu Arg Leu Ser Val Lys Val Ala Ser Ser Phe
                405                 410                 415     
Thr His Ala Phe Asp Gly Ser Arg Leu Glu Glu Trp Leu Ser His Val
            420                 425                 430         
Val Gly Ala Val Tyr Ala Pro Lys Leu Asn Val Ala Leu Asp Val Gly
        435                 440                 445             
Ile Pro Leu Pro Lys Val Leu Asn Ile Asn Phe Ser Asn Ser Val Leu
    450                 455                 460                 
Glu Ile Val Glu Asn Ala Val Val Leu Thr Val Ala Ser
465                 470                 475         


<210> 9047
<211> 226
<212> PRT
<213> Homo sapiens

<400> 9047
Trp Ser Gln Gly Cys Arg Ala Phe Leu Gly Ser Ala Gly Ala Ala Pro
 1               5                  10                  15      
Pro His Pro Pro Val Val Leu Met Trp Arg Leu Ala Leu Gly Gly Val
            20                  25                  30          
Phe Leu Ala Ala Ala Gln Ala Cys Val Phe Cys Arg Leu Pro Ala His
        35                  40                  45              
Asp Leu Ser Gly Arg Leu Ala Arg Leu Cys Ser Gln Met Glu Ala Arg
    50                  55                  60                  
Gln Lys Glu Cys Gly Ala Ser Pro Asp Phe Ser Ala Phe Ala Leu Asp
65                  70                  75                  80  
Glu Val Ser Met Asn Lys Val Thr Glu Lys Thr His Arg Val Leu Arg
                85                  90                  95      
Val Met Glu Ile Lys Glu Ala Val Ser Ser Leu Pro Ser Tyr Trp Ser
            100                 105                 110         
Trp Leu Arg Lys Thr Lys Leu Pro Glu Tyr Thr Arg Glu Ala Leu Cys
        115                 120                 125             
Pro Pro Ala Cys Arg Gly Ser Thr Thr Leu Tyr Asn Cys Ser Thr Cys
    130                 135                 140                 
Lys Gly Thr Glu Val Ser Cys Trp Pro Arg Lys Arg Cys Phe Pro Gly
145                 150                 155                 160 
Ser Leu Gly Ser Gln Asp Ser Ala Pro Leu His Leu Arg Ser Phe Pro
                165                 170                 175     
Ala Ser Gly Cys Ser Glu Pro Pro Gly Gly Val Pro Pro Pro Pro Ser
            180                 185                 190         
Lys Lys Trp Leu Val Lys Thr Leu Lys Thr Ser Gln Pro Pro Ala Leu
        195                 200                 205             
Arg Gly Met His Ser Gln Leu Pro His Pro Leu Glu Gly Asn Gln Ser
    210                 215                 220                 
Ala Pro
225     


<210> 9048
<211> 593
<212> PRT
<213> Homo sapiens

<400> 9048
Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg
 1               5                  10                  15      
Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys
            20                  25                  30          
Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala
        35                  40                  45              
Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln
    50                  55                  60                  
Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp
65                  70                  75                  80  
Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg
                85                  90                  95      
Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser
            100                 105                 110         
Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu
        115                 120                 125             
Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn
    130                 135                 140                 
Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala
145                 150                 155                 160 
Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val
                165                 170                 175     
Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr
            180                 185                 190         
Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly
        195                 200                 205             
Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp
    210                 215                 220                 
Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Glu Asp Pro Lys
225                 230                 235                 240 
Trp Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu
                245                 250                 255     
Gly Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly
            260                 265                 270         
Arg Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala
        275                 280                 285             
Ser Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys
    290                 295                 300                 
Gln Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln
305                 310                 315                 320 
Asp Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu
                325                 330                 335     
Arg Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly
            340                 345                 350         
Ser Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg
        355                 360                 365             
Ala Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln
    370                 375                 380                 
Gly Met Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala
385                 390                 395                 400 
Ala Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp
                405                 410                 415     
Phe Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Pro Tyr Val Lys Arg
            420                 425                 430         
Ser Gln Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe
        435                 440                 445             
Asp His Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu
    450                 455                 460                 
Leu Trp Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro
465                 470                 475                 480 
Pro Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg
                485                 490                 495     
Pro Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp
            500                 505                 510         
Lys Gln Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp
        515                 520                 525             
Leu Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala
    530                 535                 540                 
Ser Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu
545                 550                 555                 560 
Glu Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu
                565                 570                 575     
Pro Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Arg Ile Ser His Ala
            580                 585                 590         
Phe
    


<210> 9049
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 9049
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30          
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45              
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60                  
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80  
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95      
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110         
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125             
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140                 
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160 
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175     
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190         
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205             
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220                 
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240 
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255     
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270         
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285             
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300                 
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320 
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335     
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350         
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365             
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380                 
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400 
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415     
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430         
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445             
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460                 
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480 
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495     
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510         
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525             
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540                 
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560 
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575     
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590         
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605             
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620                 
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640 
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655     
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670         
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685             
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700                 
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720 
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735     
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750         
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765             
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780                 
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800 
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815     
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830         
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845             
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860                 
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880 
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895     
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910         
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925             
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940                 
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960 
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975     
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990         
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005            
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020                
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055    
Ile Glu Asn Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu
            1060                1065                1070        
Ser Pro Val Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro
        1075                1080                1085            
Arg Tyr Pro Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser
    1090                1095                1100                
Ala Ala Lys Leu Met Asp Thr Phe Asp Ser
1105                1110                


<210> 9050
<211> 1106
<212> PRT
<213> Homo sapiens

<400> 9050
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30          
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45              
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60                  
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80  
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95      
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110         
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125             
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140                 
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160 
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175     
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190         
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205             
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220                 
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240 
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255     
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270         
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285             
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300                 
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320 
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335     
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350         
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365             
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380                 
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400 
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415     
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430         
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445             
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460                 
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480 
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495     
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510         
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525             
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540                 
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560 
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575     
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590         
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605             
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620                 
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640 
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655     
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670         
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685             
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700                 
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720 
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735     
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750         
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765             
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780                 
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800 
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815     
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830         
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845             
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860                 
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880 
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895     
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910         
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925             
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940                 
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960 
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975     
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990         
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005            
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020                
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035                1040
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055    
Ile Glu Asn Lys Leu Tyr Asp Ala Gln His Ser Ser Ser Leu Val Gly
            1060                1065                1070        
Ala Ala Phe Gly Lys Ser Gln Gln Leu Phe Trp Leu Cys Cys Gln His
        1075                1080                1085            
Cys Asn Phe Ala Glu Lys Ser Arg Ile Thr Lys Thr Leu Pro Ala Leu
    1090                1095                1100                
Gln Thr
1105    


<210> 9051
<211> 503
<212> PRT
<213> Homo sapiens

<400> 9051
Met Ala Asp Ser Ala Ser Glu Ser Asp Thr Asp Gly Ala Gly Gly Asn
 1               5                  10                  15      
Ser Ser Ser Ser Ala Ala Met Gln Ser Ser Cys Ser Ser Thr Ser Gly
            20                  25                  30          
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Ser Gly Gly
        35                  40                  45              
Ile Val Ile Ser Pro Phe Arg Leu Glu Glu Leu Thr Asn Arg Leu Ala
    50                  55                  60                  
Ser Leu Gln Gln Glu Asn Lys Val Leu Lys Ile Glu Leu Glu Thr Tyr
65                  70                  75                  80  
Lys Leu Lys Cys Lys Ala Leu Gln Glu Glu Asn Arg Asp Leu Arg Lys
                85                  90                  95      
Ala Ser Val Thr Ile Glu Asp Pro Lys Trp Glu Phe Pro Arg Lys Asn
            100                 105                 110         
Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Lys Val Val
        115                 120                 125             
Lys Ala Thr Ala Phe His Leu Lys Gly Arg Gly Gly Tyr Thr Thr Val
    130                 135                 140                 
Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu Leu Arg Asp
145                 150                 155                 160 
Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His Pro His Val
                165                 170                 175     
Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu Leu Leu Ile
            180                 185                 190         
Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu Arg Glu Ser
        195                 200                 205             
Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser Arg Asn Ser
    210                 215                 220                 
Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met Gly Asp Leu
225                 230                 235                 240 
Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr Leu Ala Glu
                245                 250                 255     
Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Ala
            260                 265                 270         
Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser Arg Asp Val
        275                 280                 285             
Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg Ile Pro Val
    290                 295                 300                 
Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr Thr Thr Gln
305                 310                 315                 320 
Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Val Thr Leu
                325                 330                 335     
Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu Phe Asn Leu
            340                 345                 350         
Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys Ser Glu Glu
        355                 360                 365             
Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro Asp Lys Arg
    370                 375                 380                 
Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met Met Val Lys
385                 390                 395                 400 
Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser Asp Ser Leu
                405                 410                 415     
Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu Val Asp Cys
            420                 425                 430         
Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp Ile Glu Asn
        435                 440                 445             
Lys Leu Tyr Gly Met Ser Asp Pro Asn Trp Pro Gly Glu Ser Pro Val
    450                 455                 460                 
Pro Leu Thr Arg Ala Asp Gly Thr Asn Thr Gly Phe Pro Arg Tyr Pro
465                 470                 475                 480 
Asn Asp Ser Val Tyr Ala Asn Trp Met Leu Ser Pro Ser Ala Ala Lys
                485                 490                 495     
Leu Met Asp Thr Phe Asp Ser
            500             


<210> 9052
<211> 435
<212> PRT
<213> Homo sapiens

<400> 9052
Met Glu Glu Leu Ile Val Glu Leu Arg Leu Phe Leu Glu Leu Leu Asp
 1               5                  10                  15      
His Glu Tyr Leu Thr Ser Thr Val Arg Glu Lys Lys Ala Val Ile Thr
            20                  25                  30          
Asn Ile Leu Leu Arg Ile Gln Ser Ser Lys Gly Phe Asp Val Lys Asp
        35                  40                  45              
His Ala Gln Lys Gln Glu Thr Ala Asn Ser Leu Pro Ala Pro Pro Gln
    50                  55                  60                  
Met Pro Leu Pro Glu Ile Pro Gln Pro Trp Leu Glu Asp Pro Lys Trp
65                  70                  75                  80  
Glu Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly
                85                  90                  95      
Glu Phe Gly Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg
            100                 105                 110         
Ala Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser
        115                 120                 125             
Pro Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln
    130                 135                 140                 
Val Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp
145                 150                 155                 160 
Gly Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg
                165                 170                 175     
Gly Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser
            180                 185                 190         
Gly Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala
        195                 200                 205             
Leu Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly
    210                 215                 220                 
Met Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala
225                 230                 235                 240 
Arg Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe
                245                 250                 255     
Gly Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser
            260                 265                 270         
Gln Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp
        275                 280                 285             
His Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu
    290                 295                 300                 
Trp Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro
305                 310                 315                 320 
Glu Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro
                325                 330                 335     
Asp Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys
            340                 345                 350         
Gln Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu
        355                 360                 365             
Glu Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser
    370                 375                 380                 
Thr Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu
385                 390                 395                 400 
Thr Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro
                405                 410                 415     
Ser Thr Trp Ile Glu Asn Lys Leu Tyr Gly Arg Ile Ser His Ala Phe
            420                 425                 430         
Thr Arg Phe
        435 


<210> 9053
<211> 956
<212> PRT
<213> Homo sapiens

<400> 9053
Met Pro Pro Arg Ala Pro Pro Ala Pro Gly Pro Arg Pro Pro Pro Arg
 1               5                  10                  15      
Ala Ala Ala Ala Thr Asp Thr Ala Ala Gly Ala Gly Gly Ala Gly Gly
            20                  25                  30          
Ala Gly Gly Ala Gly Gly Pro Gly Phe Arg Pro Leu Ala Pro Arg Pro
        35                  40                  45              
Trp Arg Trp Leu Leu Leu Leu Ala Leu Pro Ala Ala Cys Ser Ala Pro
    50                  55                  60                  
Pro Pro Arg Pro Val Tyr Thr Asn His Trp Ala Val Gln Val Leu Gly
65                  70                  75                  80  
Gly Pro Ala Glu Ala Asp Arg Val Ala Ala Ala His Gly Tyr Leu Asn
                85                  90                  95      
Leu Gly Gln Ile Gly Asn Leu Glu Asp Tyr Tyr His Phe Tyr His Ser
            100                 105                 110         
Lys Thr Phe Lys Arg Ser Thr Leu Ser Ser Arg Gly Pro His Thr Phe
        115                 120                 125             
Leu Arg Met Asp Pro Gln Val Lys Trp Leu Gln Gln Gln Glu Val Lys
    130                 135                 140                 
Arg Arg Val Lys Arg Gln Val Arg Ser Asp Pro Gln Ala Leu Tyr Phe
145                 150                 155                 160 
Asn Asp Pro Ile Trp Ser Asn Met Trp Tyr Leu His Cys Gly Asp Lys
                165                 170                 175     
Asn Ser Arg Cys Arg Ser Glu Met Asn Val Gln Ala Ala Trp Lys Arg
            180                 185                 190         
Gly Tyr Thr Gly Lys Asn Val Val Val Thr Ile Leu Asp Asp Gly Ile
        195                 200                 205             
Glu Arg Asn His Pro Asp Leu Ala Pro Asn Tyr Asp Ser Tyr Ala Ser
    210                 215                 220                 
Tyr Asp Val Asn Gly Asn Asp Tyr Asp Pro Ser Pro Arg Tyr Asp Ala
225                 230                 235                 240 
Ser Asn Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala
                245                 250                 255     
Ser Ala Asn Asn Ser Tyr Cys Ile Val Gly Ile Ala Tyr Asn Ala Lys
            260                 265                 270         
Ile Gly Gly Ile Arg Met Leu Asp Gly Asp Val Thr Asp Val Val Glu
        275                 280                 285             
Ala Lys Ser Leu Gly Ile Arg Pro Asn Tyr Ile Asp Ile Tyr Ser Ala
    290                 295                 300                 
Ser Trp Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Gly Arg
305                 310                 315                 320 
Leu Ala Lys Gln Ala Phe Glu Tyr Gly Ile Lys Lys Gly Arg Gln Gly
                325                 330                 335     
Leu Gly Ser Ile Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu Gly
            340                 345                 350         
Asp Tyr Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser
        355                 360                 365             
Val Ser Ser Ala Thr Glu Asn Gly Tyr Lys Pro Trp Tyr Leu Glu Glu
    370                 375                 380                 
Cys Ala Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Ala Phe Tyr Glu
385                 390                 395                 400 
Arg Lys Ile Val Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Gly His
                405                 410                 415     
Thr Gly Thr Ser Val Ser Ala Pro Met Val Ala Gly Ile Ile Ala Leu
            420                 425                 430         
Ala Leu Glu Ala Asn Ser Gln Leu Thr Trp Arg Asp Val Gln His Leu
        435                 440                 445             
Leu Val Lys Thr Ser Arg Pro Ala His Leu Lys Ala Ser Asp Trp Lys
    450                 455                 460                 
Val Asn Gly Ala Gly His Lys Val Ser His Phe Tyr Gly Phe Gly Leu
465                 470                 475                 480 
Val Asp Ala Glu Ala Leu Val Val Glu Ala Lys Lys Trp Thr Ala Val
                485                 490                 495     
Pro Ser Gln His Met Cys Val Ala Ala Ser Asp Lys Arg Pro Arg Ser
            500                 505                 510         
Ile Pro Leu Val Gln Val Leu Arg Thr Thr Ala Leu Thr Ser Ala Cys
        515                 520                 525             
Ala Glu His Ser Asp Gln Arg Val Val Tyr Leu Glu His Val Val Val
    530                 535                 540                 
Arg Thr Ser Ile Ser His Pro Arg Arg Gly Asp Leu Gln Ile Tyr Leu
545                 550                 555                 560 
Val Ser Pro Ser Gly Thr Lys Ser Gln Leu Leu Ala Lys Arg Leu Leu
                565                 570                 575     
Asp Leu Ser Asn Glu Gly Phe Thr Asn Trp Glu Phe Met Thr Val His
            580                 585                 590         
Cys Trp Gly Glu Lys Ala Glu Gly Gln Trp Thr Leu Glu Ile Gln Asp
        595                 600                 605             
Leu Pro Ser Gln Val Arg Asn Pro Glu Lys Gln Gly Lys Leu Lys Glu
    610                 615                 620                 
Trp Ser Leu Ile Leu Tyr Gly Thr Ala Glu His Pro Tyr His Thr Phe
625                 630                 635                 640 
Ser Ala His Gln Ser Arg Ser Arg Met Leu Glu Leu Ser Ala Pro Glu
                645                 650                 655     
Leu Glu Pro Pro Lys Ala Ala Leu Ser Pro Ser Gln Val Glu Val Pro
            660                 665                 670         
Glu Asp Glu Glu Asp Tyr Thr Gly Val Cys His Pro Glu Cys Gly Asp
        675                 680                 685             
Lys Gly Cys Asp Gly Pro Asn Ala Asp Gln Cys Leu Asn Cys Val His
    690                 695                 700                 
Phe Ser Leu Gly Ser Val Lys Thr Ser Arg Lys Cys Val Ser Val Cys
705                 710                 715                 720 
Pro Leu Gly Tyr Phe Gly Asp Thr Ala Ala Arg Arg Cys Arg Arg Cys
                725                 730                 735     
His Lys Gly Cys Glu Thr Cys Ser Ser Arg Ala Ala Thr Gln Cys Leu
            740                 745                 750         
Ser Cys Arg Arg Gly Phe Tyr His His Gln Glu Met Asn Thr Cys Val
        755                 760                 765             
Thr Leu Cys Pro Ala Gly Phe Tyr Ala Asp Glu Ser Gln Lys Asn Cys
    770                 775                 780                 
Leu Lys Cys His Pro Ser Cys Lys Lys Cys Val Asp Glu Pro Glu Lys
785                 790                 795                 800 
Cys Thr Val Cys Lys Glu Gly Phe Ser Leu Ala Arg Gly Ser Cys Ile
                805                 810                 815     
Pro Asp Cys Glu Pro Gly Thr Tyr Phe Asp Ser Glu Leu Ile Arg Cys
            820                 825                 830         
Gly Glu Cys His His Thr Cys Gly Thr Cys Val Gly Pro Gly Arg Glu
        835                 840                 845             
Glu Cys Ile His Cys Ala Lys Asn Phe His Phe His Asp Trp Lys Cys
    850                 855                 860                 
Val Pro Ala Cys Gly Glu Gly Phe Tyr Pro Glu Glu Met Pro Gly Leu
865                 870                 875                 880 
Pro His Lys Val Cys Arg Arg Cys Asp Glu Asn Cys Leu Ser Cys Ala
                885                 890                 895     
Gly Ser Ser Arg Asn Cys Ser Arg Cys Lys Thr Gly Phe Thr Gln Leu
            900                 905                 910         
Gly Thr Ser Cys Ile Thr Asn His Thr Cys Ser Asn Ala Asp Glu Thr
        915                 920                 925             
Phe Cys Glu Met Val Lys Ser Asn Arg Leu Cys Glu Arg Lys Leu Phe
    930                 935                 940                 
Ile Gln Phe Cys Cys Arg Thr Cys Leu Leu Ala Gly
945                 950                 955     


<210> 9054
<211> 969
<212> PRT
<213> Homo sapiens

<400> 9054
Met Pro Pro Arg Ala Pro Pro Ala Pro Gly Pro Arg Pro Pro Pro Arg
 1               5                  10                  15      
Ala Ala Ala Ala Thr Asp Thr Ala Ala Gly Ala Gly Gly Ala Gly Gly
            20                  25                  30          
Ala Gly Gly Ala Gly Gly Pro Gly Phe Arg Pro Leu Ala Pro Arg Pro
        35                  40                  45              
Trp Arg Trp Leu Leu Leu Leu Ala Leu Pro Ala Ala Cys Ser Ala Pro
    50                  55                  60                  
Pro Pro Arg Pro Val Tyr Thr Asn His Trp Ala Val Gln Val Leu Gly
65                  70                  75                  80  
Gly Pro Ala Glu Ala Asp Arg Val Ala Ala Ala His Gly Tyr Leu Asn
                85                  90                  95      
Leu Gly Gln Ile Gly Asn Leu Glu Asp Tyr Tyr His Phe Tyr His Ser
            100                 105                 110         
Lys Thr Phe Lys Arg Ser Thr Leu Ser Ser Arg Gly Pro His Thr Phe
        115                 120                 125             
Leu Arg Met Asp Pro Gln Val Lys Trp Leu Gln Gln Gln Glu Val Lys
    130                 135                 140                 
Arg Arg Val Lys Arg Gln Val Arg Ser Asp Pro Gln Ala Leu Tyr Phe
145                 150                 155                 160 
Asn Asp Pro Ile Trp Ser Asn Met Trp Tyr Leu His Cys Gly Asp Lys
                165                 170                 175     
Asn Ser Arg Cys Arg Ser Glu Met Asn Val Gln Ala Ala Trp Lys Arg
            180                 185                 190         
Gly Tyr Thr Gly Lys Asn Val Val Val Thr Ile Leu Asp Asp Gly Ile
        195                 200                 205             
Glu Arg Asn His Pro Asp Leu Ala Pro Asn Tyr Asp Ser Tyr Ala Ser
    210                 215                 220                 
Tyr Asp Val Asn Gly Asn Asp Tyr Asp Pro Ser Pro Arg Tyr Asp Ala
225                 230                 235                 240 
Ser Asn Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala
                245                 250                 255     
Ser Ala Asn Asn Ser Tyr Cys Ile Val Gly Ile Ala Tyr Asn Ala Lys
            260                 265                 270         
Ile Gly Gly Ile Arg Met Leu Asp Gly Asp Val Thr Asp Val Val Glu
        275                 280                 285             
Ala Lys Ser Leu Gly Ile Arg Pro Asn Tyr Ile Asp Ile Tyr Ser Ala
    290                 295                 300                 
Ser Trp Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Gly Arg
305                 310                 315                 320 
Leu Ala Lys Gln Ala Phe Glu Tyr Gly Ile Lys Lys Gly Arg Gln Gly
                325                 330                 335     
Leu Gly Ser Ile Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu Gly
            340                 345                 350         
Asp Tyr Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser
        355                 360                 365             
Val Ser Ser Ala Thr Glu Asn Gly Tyr Lys Pro Trp Tyr Leu Glu Glu
    370                 375                 380                 
Cys Ala Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Ala Phe Tyr Glu
385                 390                 395                 400 
Arg Lys Ile Val Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Gly His
                405                 410                 415     
Thr Gly Thr Ser Val Ser Ala Pro Met Val Ala Gly Ile Ile Ala Leu
            420                 425                 430         
Ala Leu Glu Ala Asn Ser Gln Leu Thr Trp Arg Asp Val Gln His Leu
        435                 440                 445             
Leu Val Lys Thr Ser Arg Pro Ala His Leu Lys Ala Ser Asp Trp Lys
    450                 455                 460                 
Val Asn Gly Ala Gly His Lys Val Ser His Phe Tyr Gly Phe Gly Leu
465                 470                 475                 480 
Val Asp Ala Glu Ala Leu Val Val Glu Ala Lys Lys Trp Thr Ala Val
                485                 490                 495     
Pro Ser Gln His Met Cys Val Ala Ala Ser Asp Lys Arg Pro Arg Ser
            500                 505                 510         
Ile Pro Leu Val Gln Val Leu Arg Thr Thr Ala Leu Thr Ser Ala Cys
        515                 520                 525             
Ala Glu His Ser Asp Gln Arg Val Val Tyr Leu Glu His Val Val Val
    530                 535                 540                 
Arg Thr Ser Ile Ser His Pro Arg Arg Gly Asp Leu Gln Ile Tyr Leu
545                 550                 555                 560 
Val Ser Pro Ser Gly Thr Lys Ser Gln Leu Leu Ala Lys Arg Leu Leu
                565                 570                 575     
Asp Leu Ser Asn Glu Gly Phe Thr Asn Trp Glu Phe Met Thr Val His
            580                 585                 590         
Cys Trp Gly Glu Lys Ala Glu Gly Gln Trp Thr Leu Glu Ile Gln Asp
        595                 600                 605             
Leu Pro Ser Gln Val Arg Asn Pro Glu Lys Gln Gly Lys Leu Lys Glu
    610                 615                 620                 
Trp Ser Leu Ile Leu Tyr Gly Thr Ala Glu His Pro Tyr His Thr Phe
625                 630                 635                 640 
Ser Ala His Gln Ser Arg Ser Arg Met Leu Glu Leu Ser Ala Pro Glu
                645                 650                 655     
Leu Glu Pro Pro Lys Ala Ala Leu Ser Pro Ser Gln Val Glu Val Pro
            660                 665                 670         
Glu Asp Glu Glu Asp Tyr Thr Ala Gln Ser Thr Pro Gly Ser Ala Asn
        675                 680                 685             
Ile Leu Gln Thr Ser Val Cys His Pro Glu Cys Gly Asp Lys Gly Cys
    690                 695                 700                 
Asp Gly Pro Asn Ala Asp Gln Cys Leu Asn Cys Val His Phe Ser Leu
705                 710                 715                 720 
Gly Ser Val Lys Thr Ser Arg Lys Cys Val Ser Val Cys Pro Leu Gly
                725                 730                 735     
Tyr Phe Gly Asp Thr Ala Ala Arg Arg Cys Arg Arg Cys His Lys Gly
            740                 745                 750         
Cys Glu Thr Cys Ser Ser Arg Ala Ala Thr Gln Cys Leu Ser Cys Arg
        755                 760                 765             
Arg Gly Phe Tyr His His Gln Glu Met Asn Thr Cys Val Thr Leu Cys
    770                 775                 780                 
Pro Ala Gly Phe Tyr Ala Asp Glu Ser Gln Lys Asn Cys Leu Lys Cys
785                 790                 795                 800 
His Pro Ser Cys Lys Lys Cys Val Asp Glu Pro Glu Lys Cys Thr Val
                805                 810                 815     
Cys Lys Glu Gly Phe Ser Leu Ala Arg Gly Ser Cys Ile Pro Asp Cys
            820                 825                 830         
Glu Pro Gly Thr Tyr Phe Asp Ser Glu Leu Ile Arg Cys Gly Glu Cys
        835                 840                 845             
His His Thr Cys Gly Thr Cys Val Gly Pro Gly Arg Glu Glu Cys Ile
    850                 855                 860                 
His Cys Ala Lys Asn Phe His Phe His Asp Trp Lys Cys Val Pro Ala
865                 870                 875                 880 
Cys Gly Glu Gly Phe Tyr Pro Glu Glu Met Pro Gly Leu Pro His Lys
                885                 890                 895     
Val Cys Arg Arg Cys Asp Glu Asn Cys Leu Ser Cys Ala Gly Ser Ser
            900                 905                 910         
Arg Asn Cys Ser Arg Cys Lys Thr Gly Phe Thr Gln Leu Gly Thr Ser
        915                 920                 925             
Cys Ile Thr Asn His Thr Cys Ser Asn Ala Asp Glu Thr Phe Cys Glu
    930                 935                 940                 
Met Val Lys Ser Asn Arg Leu Cys Glu Arg Lys Leu Phe Ile Gln Phe
945                 950                 955                 960 
Cys Cys Arg Thr Cys Leu Leu Ala Gly
                965                 


<210> 9055
<211> 2070
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 121
<223> Xaa = Any Amino Acid

<400> 9055
Met Leu Phe Ser Trp Pro Phe Leu Lys Ser Val Val Ala Ala Ala Ala
 1               5                  10                  15      
Ala Ala Ala Asp Lys Trp Leu Glu Asp Asp Phe Arg Val Lys Asp Glu
            20                  25                  30          
Thr Glu Leu Thr Met His Gln Ser Val Glu Ser Asp Ile His Gly Leu
        35                  40                  45              
His Lys Ile Ile Asp Asp Thr Asn Val Thr Gln Leu Gln Leu Glu Ala
    50                  55                  60                  
Glu Val Lys Ala Leu Lys Glu Glu Leu Leu Phe Met Lys Lys Asn His
65                  70                  75                  80  
Glu Glu Glu Val Lys Gly Leu Gln Ser Gln Ile Ala Ser Ser Gly Leu
                85                  90                  95      
Ser Met Glu Val Asp Thr Pro Lys Ser Gln Asp Leu Thr Lys Ile Met
            100                 105                 110         
Ala Asp Ile Gln Ala Gln Tyr Asp Xaa Leu Ala Arg Glu Asn Gln Glu
        115                 120                 125             
Glu Leu Asp Lys Tyr Gly Ser Gln Gln Thr Glu Glu Ser Thr Thr Met
    130                 135                 140                 
Val Thr Thr Gln Ser Ala Glu Val Gly Ala Ala Glu Met Ala Leu Thr
145                 150                 155                 160 
Glu Leu Arg His Thr Val Gln Ser Leu Glu Ile Asp Leu Asp Ser Met
                165                 170                 175     
Arg Asn Leu Lys Ala Ser Leu Glu Ser Ser Leu Arg Lys Val Glu Ala
            180                 185                 190         
Arg Tyr Ala Leu Gln Met Glu Gln Ile Asn Gly Ile Leu Leu His Leu
        195                 200                 205             
Glu Ser Glu Leu Ala Gln Ile Arg Ala Glu Gly Gln Cys Gln Ala Gln
    210                 215                 220                 
Glu Tyr Lys Ala Leu Leu Asn Ile Lys Val Lys Leu Glu Ala Lys Ile
225                 230                 235                 240 
Ala Thr Tyr Cys His Leu Leu Glu Asp Gly Lys Asp Phe Asn Leu Gly
                245                 250                 255     
Asp Ala Leu Asp Thr Ser Asn Ser Met Gln Thr Ile Gln Lys Thr Thr
            260                 265                 270         
Ile Cys Arg Ile Val Asp His Lys Val Met Ser Asp Ile Lys Pro Ala
        275                 280                 285             
Glu Ala Gly His Val Met Gln Glu Glu Ser Ala Asn Asp Met Glu Cys
    290                 295                 300                 
Glu Gln Leu Pro Ala Glu Ile Leu Arg Gln Val Thr Val His Arg Asp
305                 310                 315                 320 
Pro Ile Tyr Gly Phe Gly Phe Val Ala Gly Ser Glu Arg Pro Val Val
                325                 330                 335     
Val Arg Ser Val Arg Pro Gly Gly Pro Ser Glu Asn Lys Leu Leu Ala
            340                 345                 350         
Gly Asp Gln Ile Val Ala Ile Asn Glu Glu Asp Val Ser Glu Ala Pro
        355                 360                 365             
Arg Glu Arg Leu Ile Glu Leu Ile Arg Ser Ala Lys Glu Phe Ile Val
    370                 375                 380                 
Leu Thr Val Leu His Thr His Gln Ser Pro Lys Ser Ala Phe Ile Ser
385                 390                 395                 400 
Ala Ala Lys Lys Ala Lys Leu Arg Ser Asn Pro Val Lys Val Arg Phe
                405                 410                 415     
Ser Glu Gln Val Ala Val Gly Glu Thr Asp Ala Lys Met Met Lys Lys
            420                 425                 430         
Glu Ala Leu Leu Leu Ile Pro Asn Val Leu Lys Val Phe Leu Glu Asn
        435                 440                 445             
Gly Gln Ile Lys Ser Phe Thr Phe Asp Gly Arg Thr Thr Val Lys Asp
    450                 455                 460                 
Val Met Leu Thr Leu Gln Asp Arg Leu Ser Leu Arg Phe Ile Glu His
465                 470                 475                 480 
Phe Ala Leu Val Leu Glu Tyr Ala Gly Pro Glu Gln Asn His Lys Phe
                485                 490                 495     
Leu Leu Leu Gln Asp Lys Gln Pro Leu Ala Tyr Val Val Gln Arg Thr
            500                 505                 510         
His Tyr His Gly Met Lys Cys Leu Phe Arg Ile Ser Phe Phe Pro Lys
        515                 520                 525             
Asp Pro Val Glu Leu Leu Arg Arg Asp Pro Ala Ala Phe Glu Tyr Leu
    530                 535                 540                 
Tyr Ile Gln Ser Arg Asn Asp Val Ile Arg Glu Arg Phe Gly Met Asp
545                 550                 555                 560 
Pro Lys Pro Glu Met Leu Leu Gly Leu Ala Ala Leu His Ile Tyr Ile
                565                 570                 575     
Thr Val Ser Ala Thr Arg Pro Ser Gln Lys Ile Ser Leu Lys Asn Val
            580                 585                 590         
Glu Lys Glu Trp Gly Leu Glu Pro Phe Leu Pro Pro Ser Leu Leu Gln
        595                 600                 605             
Val Ile Lys Glu Lys Asn Leu Arg Lys Ser Leu Ser Gln Gln Leu Lys
    610                 615                 620                 
Ala His Gln Thr His Pro Ser Cys Gly Thr Lys Gly Ser Ala Ile Gln
625                 630                 635                 640 
Ala Lys Leu Gln Tyr Leu Arg Ile Leu Asn Glu Leu Pro Thr Phe Thr
                645                 650                 655     
Gly Val Leu Phe Asn Thr Val Gly Leu Asp Glu Lys Gln Ser Ala Thr
            660                 665                 670         
Thr Leu Leu Val Gly Pro Arg His Gly Ile Ser His Val Ile Asp Leu
        675                 680                 685             
Lys Thr Asn Leu Thr Thr Val Leu Ser Glu Phe Ser Lys Ile Ser Lys
    690                 695                 700                 
Ile Gln Leu Phe Arg Glu Asn Gln Gly Val Ala Arg Val Glu Thr Ser
705                 710                 715                 720 
Ile Met Asp Ala Lys Pro Leu Val Leu Leu Met Glu Trp Pro Glu Ala
                725                 730                 735     
Thr Asn Phe Ala Cys Leu Ile Ala Gly Tyr Cys Arg Leu Leu Leu Asp
            740                 745                 750         
Ser Arg Lys Met Val Phe Ser Arg Pro Ala Ser Gln Pro Leu Pro Pro
        755                 760                 765             
Pro Met Ile Lys Ala Asp Tyr Met His Ser Ala His Arg Pro Val Thr
    770                 775                 780                 
Gly Gly His Leu Gly Lys Lys Glu Ser Ser Tyr Val Gly Ser Val Gly
785                 790                 795                 800 
Thr Ser Pro Arg Lys Ser Ser Arg Cys Thr Pro Pro Pro Ala Asp Ser
                805                 810                 815     
Glu Leu Val Ser Phe Cys Tyr Leu His Met Arg Glu Gln Arg Lys Glu
            820                 825                 830         
Gln Glu Ser Arg Thr Asp Val Asn Glu Asn Leu Ile Phe Phe Glu Glu
        835                 840                 845             
Thr Arg Pro Arg Thr Lys Ser Asp Pro Thr Ser Lys Ser Ser Gly Gln
    850                 855                 860                 
Gly Tyr Glu Val Val Pro Asp Asp Phe Asp Ala Ala Ser Leu Asp His
865                 870                 875                 880 
Glu Pro Cys Ala Ser Arg Ala Arg Ser Tyr Thr Leu Asp Asn Ser Leu
                885                 890                 895     
Gly Ala Glu Ala Leu Asn Phe Tyr Cys Asp Ser Cys Lys Ala Lys Leu
            900                 905                 910         
Gln Glu Gln Leu Gly Pro Arg Lys Gly Gly Lys Pro Gly Ser Ser Arg
        915                 920                 925             
Asp Asn Ile Val Asp Leu Met Ser Leu Pro Pro Pro Gly Ser Glu Glu
    930                 935                 940                 
Glu Glu Glu Glu Glu Asp Glu Thr Thr Ser Leu Leu Pro Ala Ile Ala
945                 950                 955                 960 
Ala Pro Pro Pro Gly Phe Arg Asp Asn Ser Ser Asp Glu Asp Asp Pro
                965                 970                 975     
Lys Arg Arg Ala Val Gln Ser Gln Glu Gln Gly Arg His Leu Arg Gly
            980                 985                 990         
Leu Leu Tyr Asp Glu Ile Pro Val Thr Leu Ile Asp Ser Val Gln Thr
        995                 1000                1005            
Arg Thr Val Arg Asp His Ala Gln Glu Leu Asp Asp Ala Leu Val Ser
    1010                1015                1020                
Thr Leu Gln Ala Leu Glu Ala Leu Ala Ala Ser Glu Asp Gly Pro His
1025                1030                1035                1040
Pro Pro Pro Pro Gln Thr Ala Gly Leu Ile Val Leu Ala Thr Ile Thr
                1045                1050                1055    
Pro Glu Ser Ser Leu Asp Ser Gly His Glu Thr Asn Ser Ser Glu Leu
            1060                1065                1070        
Thr Asp Met Ser Glu Met Met Ser Ala Met Lys Gln His Gln Asn Thr
        1075                1080                1085            
Thr Tyr Phe Leu Ala Gln His Leu Asn Lys Asp Ser Leu Leu Ala Arg
    1090                1095                1100                
Lys Asp Leu Pro Phe Arg Ile Gln Ser Cys Ala Ala Gln Ala Val Leu
1105                1110                1115                1120
Thr Ala Pro Tyr Ser Leu Gly Arg Pro Asp Pro Asn Pro Ser Leu Gln
                1125                1130                1135    
Pro Ile Ala Thr Gly Gln Ser Pro Gly Pro Pro Gly Ala Arg Arg Lys
            1140                1145                1150        
Leu Pro Gln Ser Glu Gly Gln Val Gln Gly Glu Arg Thr Tyr Ser Leu
        1155                1160                1165            
Ala Val His Pro Ala Leu Ser Pro Gln Leu Ser Glu Gln Lys Asn Leu
    1170                1175                1180                
Ser Leu Leu Ser Pro Val Pro Glu Asp Lys Gly Pro Gly His Thr Arg
1185                1190                1195                1200
Ala Gly Leu Glu Met Ser Leu Arg Ala Ala Thr Ser Ser Leu Ser Glu
                1205                1210                1215    
Glu Gln Val Ser Glu Leu Arg Asp Asn Leu Pro Lys Glu Val Arg Leu
            1220                1225                1230        
Ser Pro Lys Leu Ile Leu Asp Pro Lys Ser Ser Val Thr Pro Ala Ile
        1235                1240                1245            
Ile Ser Ala Ala Leu Gln Gln Val Val His Asn Lys Ser Leu Val Thr
    1250                1255                1260                
Ala Gly Gly Ala Leu Gly Asn Pro Pro Ser Arg Gly Glu Arg Arg Leu
1265                1270                1275                1280
Glu Ala Ser Met Gly Arg Pro Glu Val Ser Met Met Ser Ser Ser Ala
                1285                1290                1295    
Ser Lys Asn Leu Lys Phe Lys Ile Ser Pro Ser Ala Pro Glu Thr Ser
            1300                1305                1310        
Trp Asn Ser Gln His Gln Leu Gly Ala Glu Val Ser Ser Ser Pro Arg
        1315                1320                1325            
Ala Pro Thr Gly Ser Arg Ala Asp Ser Leu His Leu Ser Gln Gln Glu
    1330                1335                1340                
Asp Ser Leu Pro Val Gln Asn Phe Pro Pro Lys Ser Tyr Leu Leu Arg
1345                1350                1355                1360
Thr Ser Arg Glu Ser Val Gly Lys Gln Ala Thr Gly Glu Val Ala Gly
                1365                1370                1375    
Lys Gly Gly Pro Val Gly Gly Lys Pro Thr Leu Gln Lys Gln Gly Thr
            1380                1385                1390        
Ile Ser Ser Gln Gly Glu Lys Ala Gln Leu Glu Ser Thr Pro Lys Arg
        1395                1400                1405            
Ser Lys Leu Glu Glu Thr Ser Leu Val Pro Arg Ala Thr Tyr Pro Met
    1410                1415                1420                
Ala Leu Gln Ser Pro Ser Cys Gln Ser Arg Ser His Ser Pro Ser Cys
1425                1430                1435                1440
Gln Pro His Gly His Ser Pro Ser Ser Gln Ser Arg Gly Gln Ser Pro
                1445                1450                1455    
Ser Cys Gln Pro Arg Gly Gln Ser Pro Leu Arg Ser Gln Ala Ala Ser
            1460                1465                1470        
Arg Gln Val Ser Thr Met Pro Ser Arg Lys Leu Glu Thr Thr Leu Asn
        1475                1480                1485            
Gly Ala His Ser Thr Ser Glu Gly Pro Ala Lys Pro Lys Ser Ser Arg
    1490                1495                1500                
Gly Pro Phe Arg Leu Arg Asn Leu Phe Ser Ala Thr Phe Pro Thr Arg
1505                1510                1515                1520
Gln Lys Lys Glu Thr Asp Glu Arg Gln Ala Gln Leu Gln Lys Val Lys
                1525                1530                1535    
Gln Tyr Glu Leu Glu Phe Leu Glu Glu Leu Leu Lys Pro Pro Ser Gln
            1540                1545                1550        
Gly Glu Leu Pro Gly Thr Glu Tyr Leu Gln Pro Pro Ala Pro Gly Arg
        1555                1560                1565            
Cys Ser Cys Gln Leu Arg Ser Ser Pro Val Gln Gln Gly Pro Gly Met
    1570                1575                1580                
Ser Arg Glu Gln Arg Arg Ser Cys Asp Cys Lys Arg Ile Cys Arg Gly
1585                1590                1595                1600
Gly Arg Pro Gln Ala Thr Gln Thr Pro Val Pro Ser Leu Arg Gly Arg
                1605                1610                1615    
Glu Arg Asp Arg Val Leu Pro Ser Gln Arg Gln Pro Glu Ala Gly Pro
            1620                1625                1630        
Gly Val Ser Leu Ser Ser Pro Ile Asn Val Gln Arg Ile Arg Ser Thr
        1635                1640                1645            
Ser Leu Glu Ser Arg Glu Cys Arg Ser Asp Pro Glu Ser Gly Val Ser
    1650                1655                1660                
Cys Leu Thr Thr Cys Ala Ser Gly Gly Glu Cys Leu Gly Ala Pro Asn
1665                1670                1675                1680
Tyr Arg Lys Leu Met Arg Arg Tyr Ser Ile Ser Glu Leu Asp Gln Gly
                1685                1690                1695    
Asp Arg Ala Ser Leu Thr Ser Asp Val Tyr Pro His Pro Pro Leu Gly
            1700                1705                1710        
Met Leu Pro Arg Glu Ala Lys Glu Val Glu Ala Ser Leu Pro Ile Ala
        1715                1720                1725            
Leu Gly Pro Lys Ser Arg Ser Leu Glu Ser Pro Thr Leu Gly Asp Pro
    1730                1735                1740                
Ser Tyr Val Gln Val Ala Pro Glu Thr Lys Gly Pro Arg Gln Met Ala
1745                1750                1755                1760
Val Phe Ser Leu Pro Glu Glu Val Tyr Arg Lys Pro Ala Glu Leu Asp
                1765                1770                1775    
Glu Asp Ser Glu Ser Ser Lys Cys Cys Ser Ile Arg Tyr Cys Phe Tyr
            1780                1785                1790        
Tyr Arg Lys Cys Asp Met Ala Asp Asp Ala Ser Asp Gly Lys Asp Glu
        1795                1800                1805            
Leu Ser Tyr Ser Ile Pro Met Lys Ile Leu Pro Gly Met Lys Leu Asp
    1810                1815                1820                
Glu Gln Val Val Pro Val Val Ser Arg Thr Leu Gln Val Leu Asp Ala
1825                1830                1835                1840
Ala Thr Cys Ser Ser Ser Ser Pro Glu Ala Ser Arg Thr Gln Glu Ile
                1845                1850                1855    
Asp Leu Arg Val Ser Thr Phe Glu Gly Ser Leu Ala Lys Ile Asn Ala
            1860                1865                1870        
Leu Arg Ala His Ala Tyr Gly Leu Pro Asp Gly Phe Leu Ala Ala Arg
        1875                1880                1885            
Leu Asp Thr Asn Glu Leu Leu Thr Val Leu Arg Gln Cys Val Ala Ser
    1890                1895                1900                
Pro Glu Ala Arg Ala Pro Lys Pro Tyr Val Ser Gln Ile Ser Glu Tyr
1905                1910                1915                1920
Lys Leu Glu Leu Ala Leu Lys Phe Lys Glu Leu Arg Ala Ser Cys Arg
                1925                1930                1935    
Arg Val Ala Asn Val Asp Lys Ser Pro Thr His Met Leu Ala Ala Ile
            1940                1945                1950        
Thr Gly Ser Phe Gln Val Leu Ser Ser Leu Ile Glu Thr Phe Val Arg
        1955                1960                1965            
Leu Val Phe Ile Val Arg Ser Glu Ala Gln Arg Gln Glu Leu Leu Ala
    1970                1975                1980                
Lys Val Glu Glu Val Val Arg Asn Tyr Thr Phe Leu Leu Arg Ala Ala
1985                1990                1995                2000
Glu Glu Ser Thr Ala Arg Asn Leu Asn Gln Gln Gln Gln Gln Gln Gln
                2005                2010                2015    
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            2020                2025                2030        
Gln Gln Gln Gln Val Ala Ala Ala Ala Gly Ala Ala Thr Glu His Pro
        2035                2040                2045            
Pro Gly Ser Pro Thr Ser Ala Thr Val Met Ser Thr Phe Thr His Ser
    2050                2055                2060                
Leu Lys Thr Leu Ile Lys
2065                2070


<210> 9056
<211> 1997
<212> PRT
<213> Homo sapiens

<400> 9056
Met Leu Ser His Gly Ala Gly Leu Ala Leu Trp Ile Thr Leu Ser Leu
 1               5                  10                  15      
Leu Gln Thr Gly Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala
            20                  25                  30          
Glu Ser Lys Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu
        35                  40                  45              
Gly Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly
    50                  55                  60                  
Ala Ala Leu Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys
65                  70                  75                  80  
Asn Leu Gln Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Lys Ile Ile
                85                  90                  95      
Ser Leu Asp Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro
            100                 105                 110         
Pro Ala Arg Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Gly Leu
        115                 120                 125             
His Val Trp Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val
    130                 135                 140                 
Gln Leu Phe Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln
145                 150                 155                 160 
Glu Ser Thr Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly
                165                 170                 175     
Ser Lys Tyr Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser
            180                 185                 190         
Phe Ser Val Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp
        195                 200                 205             
Ile Gly Ile Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His
    210                 215                 220                 
Gly Ser Gly Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly
225                 230                 235                 240 
Ile Leu Val His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala
                245                 250                 255     
Phe His Gly Leu Ser Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr
            260                 265                 270         
Glu Ala Ala Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala
        275                 280                 285             
Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr
    290                 295                 300                 
Ser Leu Lys Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr
305                 310                 315                 320 
Asn Ile Thr Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu
                325                 330                 335     
Ala Pro Trp Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg
            340                 345                 350         
Leu Tyr Gln Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln
        355                 360                 365             
Lys Met Ala Val Gly Arg Thr Phe Pro Asp Lys Val Ala Asn Leu Glu
    370                 375                 380                 
Ala Asn Asn Asn Gly Arg Met Arg Ser Leu Val Val Ser Trp Ser Pro
385                 390                 395                 400 
Pro Ala Gly Asp Trp Glu Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser
                405                 410                 415     
Val Val Leu Leu Asn Ile Thr Val Gly Lys Glu Glu Thr Gln Tyr Val
            420                 425                 430         
Met Asp Asp Thr Gly Leu Val Pro Gly Arg Gln Tyr Glu Val Glu Val
        435                 440                 445             
Ile Val Glu Ser Gly Asn Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg
    450                 455                 460                 
Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn Glu
465                 470                 475                 480 
Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu Trp Glu Lys
                485                 490                 495     
Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile His Lys Ser
            500                 505                 510         
Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val Pro Gly
        515                 520                 525             
Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu Lys Asn
    530                 535                 540                 
Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp Leu
545                 550                 555                 560 
His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp Thr
                565                 570                 575     
Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His Glu
            580                 585                 590         
Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr
        595                 600                 605             
Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val Val Val Thr
    610                 615                 620                 
Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu Gly Arg
625                 630                 635                 640 
Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly Arg
                645                 650                 655     
Asn Asp Tyr Leu Ser Val Ser Trp Leu Val Ala Pro Gly Asp Val Asp
            660                 665                 670         
Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val Gln Ser Leu
        675                 680                 685             
Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro
    690                 695                 700                 
Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu
705                 710                 715                 720 
Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val Gln Gly
                725                 730                 735     
Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp
            740                 745                 750         
Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys Asn
        755                 760                 765             
Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser Glu Asn Glu
    770                 775                 780                 
Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val Thr Val
785                 790                 795                 800 
Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly Asn Gly Arg
                805                 810                 815     
Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Arg Asn Arg Ser Thr
            820                 825                 830         
Glu Asp Leu His Val Thr Trp Ser Gly Ala Asn Gly Asp Val Asp Gln
        835                 840                 845             
Tyr Glu Ile Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro Pro Phe
    850                 855                 860                 
His Leu Val Asn Thr Ala Thr Glu Tyr Arg Phe Thr Ser Leu Thr Pro
865                 870                 875                 880 
Gly Arg Gln Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val Gln
                885                 890                 895     
Gln Ser Ala Phe Ile Glu Gly Phe Thr Val Pro Ser Ala Val Lys Asn
            900                 905                 910         
Ile His Ile Ser Pro Asn Gly Ala Thr Asp Ser Leu Thr Val Asn Trp
        915                 920                 925             
Thr Pro Gly Gly Gly Asp Val Asp Ser Tyr Thr Val Ser Ala Phe Arg
    930                 935                 940                 
His Ser Gln Lys Val Asp Ser Gln Thr Ile Pro Lys His Val Phe Glu
945                 950                 955                 960 
His Thr Phe His Arg Leu Glu Ala Gly Glu Gln Tyr Gln Ile Met Ile
                965                 970                 975     
Ala Ser Val Ser Gly Ser Leu Lys Asn Gln Ile Asn Val Val Gly Arg
            980                 985                 990         
Thr Val Pro Ala Ser Val Gln Gly Val Ile Ala Asp Asn Ala Tyr Ser
        995                 1000                1005            
Ser Tyr Ser Leu Ile Val Ser Trp Gln Lys Ala Ala Gly Val Ala Glu
    1010                1015                1020                
Arg Tyr Asp Ile Leu Leu Leu Thr Glu Asn Gly Ile Leu Leu Arg Asn
1025                1030                1035                1040
Thr Ser Glu Pro Ala Thr Thr Lys Gln His Lys Phe Glu Asp Leu Thr
                1045                1050                1055    
Pro Gly Lys Lys Tyr Lys Ile Gln Ile Leu Thr Val Ser Gly Gly Leu
            1060                1065                1070        
Phe Ser Lys Glu Ala Gln Thr Glu Gly Arg Thr Val Pro Ala Ala Val
        1075                1080                1085            
Thr Asp Leu Arg Ile Thr Glu Asn Ser Thr Arg His Leu Ser Phe Arg
    1090                1095                1100                
Trp Thr Ala Ser Glu Gly Glu Leu Ser Trp Tyr Asn Ile Phe Leu Tyr
1105                1110                1115                1120
Asn Pro Asp Gly Asn Leu Gln Glu Arg Ala Gln Val Asp Pro Leu Val
                1125                1130                1135    
Gln Ser Phe Ser Phe Gln Asn Leu Leu Gln Gly Arg Met Tyr Lys Met
            1140                1145                1150        
Val Ile Val Thr His Ser Gly Glu Leu Ser Asn Glu Ser Phe Ile Phe
        1155                1160                1165            
Gly Arg Thr Val Pro Ala Ser Val Ser His Leu Arg Gly Ser Asn Arg
    1170                1175                1180                
Asn Thr Thr Asp Ser Leu Trp Phe Asn Trp Ser Pro Ala Ser Gly Asp
1185                1190                1195                1200
Phe Asp Phe Tyr Glu Leu Ile Leu Tyr Asn Pro Asn Gly Thr Lys Lys
                1205                1210                1215    
Glu Asn Trp Lys Asp Lys Asp Leu Thr Glu Trp Arg Phe Gln Gly Leu
            1220                1225                1230        
Val Pro Gly Arg Lys Tyr Val Leu Trp Val Val Thr His Ser Gly Asp
        1235                1240                1245            
Leu Ser Asn Lys Val Thr Ala Glu Ser Arg Thr Ala Pro Ser Pro Pro
    1250                1255                1260                
Ser Leu Met Ser Phe Ala Asp Ile Ala Asn Thr Ser Leu Ala Ile Thr
1265                1270                1275                1280
Trp Lys Gly Pro Pro Asp Trp Thr Asp Tyr Asn Asp Phe Glu Leu Gln
                1285                1290                1295    
Trp Leu Pro Arg Asp Ala Leu Thr Val Phe Asn Pro Tyr Asn Asn Arg
            1300                1305                1310        
Lys Ser Glu Gly Arg Ile Val Tyr Gly Leu Arg Pro Gly Arg Ser Tyr
        1315                1320                1325            
Gln Phe Asn Val Lys Thr Val Ser Gly Asp Ser Trp Lys Thr Tyr Ser
    1330                1335                1340                
Lys Pro Ile Phe Gly Ser Val Arg Thr Lys Pro Asp Lys Ile Gln Asn
1345                1350                1355                1360
Leu His Cys Arg Pro Gln Asn Ser Thr Ala Ile Ala Cys Ser Trp Ile
                1365                1370                1375    
Pro Pro Asp Ser Asp Phe Asp Gly Tyr Ser Ile Glu Cys Arg Lys Met
            1380                1385                1390        
Asp Thr Gln Glu Val Glu Phe Ser Arg Lys Leu Glu Lys Glu Lys Ser
        1395                1400                1405            
Leu Leu Asn Ile Met Met Leu Val Pro His Lys Arg Tyr Leu Val Ser
    1410                1415                1420                
Ile Lys Val Gln Ser Ala Gly Met Thr Ser Glu Val Val Glu Asp Ser
1425                1430                1435                1440
Thr Ile Thr Met Ile Asp Arg Pro Pro Pro Pro Pro Pro His Ile Arg
                1445                1450                1455    
Val Asn Glu Lys Asp Val Leu Ile Ser Lys Ser Ser Ile Asn Phe Thr
            1460                1465                1470        
Val Asn Cys Ser Trp Phe Ser Asp Thr Asn Gly Ala Val Lys Tyr Phe
        1475                1480                1485            
Thr Val Val Val Arg Glu Ala Asp Gly Ser Asp Glu Leu Lys Pro Glu
    1490                1495                1500                
Gln Gln His Pro Leu Pro Ser Tyr Leu Glu Tyr Arg His Asn Ala Ser
1505                1510                1515                1520
Ile Arg Val Tyr Gln Thr Asn Tyr Phe Ala Ser Lys Cys Ala Glu Asn
                1525                1530                1535    
Pro Asn Ser Asn Ser Lys Ser Phe Asn Ile Lys Leu Gly Ala Glu Met
            1540                1545                1550        
Glu Ser Leu Gly Gly Lys Arg Asp Pro Thr Gln Gln Lys Phe Cys Asp
        1555                1560                1565            
Gly Pro Leu Lys Pro His Thr Ala Tyr Arg Ile Ser Ile Arg Ala Phe
    1570                1575                1580                
Thr Gln Leu Phe Asp Glu Asp Leu Lys Glu Phe Thr Lys Pro Leu Tyr
1585                1590                1595                1600
Ser Asp Thr Phe Phe Ser Leu Pro Ile Thr Thr Glu Ser Glu Pro Leu
                1605                1610                1615    
Phe Gly Ala Ile Glu Gly Val Ser Ala Gly Leu Phe Leu Ile Gly Met
            1620                1625                1630        
Leu Val Ala Val Val Ala Leu Leu Ile Cys Arg Gln Lys Val Ser His
        1635                1640                1645            
Gly Arg Glu Arg Pro Ser Ala Arg Leu Ser Ile Arg Arg Asp Arg Pro
    1650                1655                1660                
Leu Ser Val His Leu Asn Leu Gly Gln Lys Gly Asn Arg Lys Thr Ser
1665                1670                1675                1680
Cys Pro Ile Lys Ile Asn Gln Phe Glu Gly His Phe Met Lys Leu Gln
                1685                1690                1695    
Ala Asp Ser Asn Tyr Leu Leu Ser Lys Glu Tyr Glu Glu Leu Lys Asp
            1700                1705                1710        
Val Gly Arg Asn Gln Ser Cys Asp Ile Ala Leu Leu Pro Glu Asn Arg
        1715                1720                1725            
Gly Lys Asn Arg Tyr Asn Asn Ile Leu Pro Tyr Asp Ala Thr Arg Val
    1730                1735                1740                
Lys Leu Ser Asn Val Asp Asp Asp Pro Cys Ser Asp Tyr Ile Asn Ala
1745                1750                1755                1760
Ser Tyr Ile Pro Gly Asn Asn Phe Arg Arg Glu Tyr Ile Val Thr Gln
                1765                1770                1775    
Gly Pro Leu Pro Gly Thr Lys Asp Asp Phe Trp Lys Met Val Trp Glu
            1780                1785                1790        
Gln Asn Val His Asn Ile Val Met Val Thr Gln Cys Val Glu Lys Gly
        1795                1800                1805            
Arg Val Lys Cys Asp His Tyr Trp Pro Ala Asp Gln Asp Ser Leu Tyr
    1810                1815                1820                
Tyr Gly Asp Leu Ile Leu Gln Met Leu Ser Glu Ser Val Leu Pro Glu
1825                1830                1835                1840
Trp Thr Ile Arg Glu Phe Lys Ile Cys Gly Glu Glu Gln Leu Asp Ala
                1845                1850                1855    
His Arg Leu Ile Arg His Phe His Tyr Thr Val Trp Pro Asp His Gly
            1860                1865                1870        
Val Pro Glu Thr Thr Gln Ser Leu Ile Gln Phe Val Arg Thr Val Arg
        1875                1880                1885            
Asp Tyr Ile Asn Arg Ser Pro Gly Ala Gly Pro Thr Val Val His Cys
    1890                1895                1900                
Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala Leu Asp Arg Ile
1905                1910                1915                1920
Leu Gln Gln Leu Asp Ser Lys Asp Ser Val Asp Ile Tyr Gly Ala Val
                1925                1930                1935    
His Asp Leu Arg Leu His Arg Val His Met Val Gln Thr Glu Cys Gln
            1940                1945                1950        
Tyr Val Tyr Leu His Gln Cys Val Arg Asp Val Leu Arg Ala Arg Lys
        1955                1960                1965            
Leu Arg Ser Glu Gln Glu Asn Pro Leu Phe Pro Ile Tyr Glu Asn Val
    1970                1975                1980                
Asn Pro Glu Tyr His Arg Asp Pro Val Tyr Ser Arg His
1985                1990                1995        


<210> 9057
<211> 2302
<212> PRT
<213> Homo sapiens

<400> 9057
Met Asp Ser Leu Ala Gly Leu Ser Pro Arg Glu Ala Ala Gly Val Leu
 1               5                  10                  15      
Ser Leu Ser Cys Val Gly Val Cys Ser Thr Cys Ala Trp Ala Trp Pro
            20                  25                  30          
His Gly Ser Met Arg Asp Leu Arg Ala Gln Val Thr Ser Gly Leu Leu
        35                  40                  45              
Pro Phe Pro Glu Val Thr Leu Gln Ala Leu Gly Glu Asp Glu Ile Thr
    50                  55                  60                  
Leu Glu Ser Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu
65                  70                  75                  80  
Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Thr
                85                  90                  95      
Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser Gly Val Asn Glu Gln Pro
            100                 105                 110         
Pro Val Val Leu Ala Val Lys Glu Phe Ser Trp Gln Lys Arg Thr Gly
        115                 120                 125             
Leu Leu Ile Gly Leu Glu Glu Thr Glu Gly Ser Val Leu Cys Leu Tyr
    130                 135                 140                 
Asp Leu Gly Ile Ser Lys Val Val Lys Ala Val Val Leu Pro Gly Arg
145                 150                 155                 160 
Val Thr Ala Ile Glu Pro Ile Ile Asn His Gly Gly Ala Ser Ala Ser
                165                 170                 175     
Thr Gln His Leu His Pro Ser Leu Arg Trp Leu Phe Gly Val Ala Ala
            180                 185                 190         
Val Val Thr Asp Val Gly Gln Ile Leu Leu Val Asp Leu Cys Leu Asp
        195                 200                 205             
Asp Leu Ser Cys Asn Gln Asn Glu Val Glu Ala Ser Asp Leu Glu Val
    210                 215                 220                 
Leu Thr Gly Ile Pro Ala Glu Val Pro His Ile Arg Glu Ser Val Met
225                 230                 235                 240 
Arg Gln Gly Arg His Leu Cys Phe Gln Leu Val Ser Pro Thr Gly Thr
                245                 250                 255     
Ala Val Ser Thr Leu Ser Tyr Ile Ser Arg Thr Asn Gln Leu Ala Val
            260                 265                 270         
Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp Asn Met Lys Ser Met Lys
        275                 280                 285             
Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly Gln Val Pro Val Tyr Ala
    290                 295                 300                 
Val Thr Phe Gln Glu Pro Glu Asn Asp Pro Arg Asn Cys Cys Tyr Leu
305                 310                 315                 320 
Trp Ala Val Gln Ser Thr Gln Asp Ser Glu Gly Asp Val Leu Ser Leu
                325                 330                 335     
His Leu Leu Gln Leu Ala Phe Gly Asn Arg Lys Cys Leu Ala Ser Gly
            340                 345                 350         
Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys Glu Glu Arg Tyr Thr Leu
        355                 360                 365             
Asp Leu Thr Gly Gly Met Phe Pro Leu Arg Gly Gln Thr Ser Asn Thr
    370                 375                 380                 
Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys Phe Arg Ser His Gly Asp
385                 390                 395                 400 
Arg Glu Glu Gly Val Asn Glu Ala Leu Ser Pro Asp Thr Ser Val Ser
                405                 410                 415     
Val Phe Thr Trp Gln Val Asn Ile Tyr Gly Gln Gly Lys Pro Ser Val
            420                 425                 430         
Tyr Leu Gly Leu Phe Gly Ile Asn Arg Trp Tyr His Ala Gln Met Pro
        435                 440                 445             
Asp Ser Leu Arg Ser Gly Glu Tyr Leu His Asn Cys Ser Tyr Phe Ala
    450                 455                 460                 
Leu Trp Ser Leu Glu Ser Val Val Ser Arg Thr Ser Pro His Gly Ile
465                 470                 475                 480 
Leu Asp Ile Leu Val His Glu Arg Ser Leu Asn Arg Gly Val Pro Pro
                485                 490                 495     
Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn Pro Ser Thr Tyr Asn Phe
            500                 505                 510         
Asp Ala Thr Cys Leu Leu Asn Ser Gly Val Val His Leu Thr Cys Thr
        515                 520                 525             
Gly Phe Gln Lys Glu Thr Leu Thr Phe Leu Lys Lys Ser Gly Pro Ser
    530                 535                 540                 
Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn Arg Cys Leu Val Ala Gly
545                 550                 555                 560 
Leu Leu Ser Pro Arg Phe Val Asp Val Gln Pro Ser Ser Leu Ser Gln
                565                 570                 575     
Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala Ala Ile Gln Thr Ser Ser
            580                 585                 590         
Leu Gly Leu Leu Thr Gly Tyr Ile Arg Arg Trp Ile Thr Glu Glu Gln
        595                 600                 605             
Pro Asn Ser Ala Thr Asn Leu Arg Phe Val Leu Glu Trp Thr Trp Asn
    610                 615                 620                 
Lys Val Val Leu Thr Lys Glu Glu Phe Asp Arg Leu Cys Val Pro Leu
625                 630                 635                 640 
Phe Asp Gly Ser Cys His Phe Met Asp Pro Gln Thr Ile Gln Ser Ile
                645                 650                 655     
Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu Asn Ile Val Leu Ser Cys
            660                 665                 670         
Phe Ala Ser Glu Ala Arg Glu Ile Thr Glu Arg Gly Leu Ile Asp Leu
        675                 680                 685             
Ser Asn Lys Phe Val Val Ser His Leu Ile Cys Gln Tyr Ala Gln Val
    690                 695                 700                 
Val Leu Trp Phe Ser His Ser Gly Leu Leu Pro Glu Gly Ile Asp Asp
705                 710                 715                 720 
Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn Tyr Pro Val Ile Gln Asn
                725                 730                 735     
Tyr Tyr Thr Ser Arg Arg Gln Lys Phe Glu Arg Leu Ser Arg Gly Lys
            740                 745                 750         
Trp Asn Pro Asp Cys Leu Met Ile Asp Gly Leu Val Ser Gln Leu Gly
        755                 760                 765             
Glu Arg Ile Glu Lys Leu Trp Lys Arg Gly Glu Gly Gly Thr Gly Lys
    770                 775                 780                 
Tyr Pro Pro Gly Ser Leu His Ala Val Leu Asp Met Tyr Leu Leu Asp
785                 790                 795                 800 
Gly Val Thr Glu Ala Ala Lys His Ser Ile Thr Ile Tyr Leu Leu Leu
                805                 810                 815     
Asp Ile Met Tyr Ser Phe Pro Asn Lys Thr Asp Thr Pro Ile Glu Ser
            820                 825                 830         
Phe Pro Thr Val Phe Ala Ile Ser Trp Gly Gln Val Lys Leu Ile Gln
        835                 840                 845             
Gly Phe Trp Leu Ile Asp His Asn Asp Tyr Glu Ser Gly Leu Asp Leu
    850                 855                 860                 
Leu Phe His Pro Ala Thr Ala Lys Pro Leu Ser Trp Gln His Ser Lys
865                 870                 875                 880 
Ile Ile Gln Ala Phe Met Ser Gln Gly Glu His Arg Gln Ala Leu Arg
                885                 890                 895     
Tyr Ile Gln Thr Met Lys Pro Thr Val Ser Ser Gly Asn Asp Val Ile
            900                 905                 910         
Leu His Leu Thr Val Leu Leu Phe Asn Arg Cys Met Val Glu Ala Trp
        915                 920                 925             
Asn Phe Leu Arg Gln His Cys Asn Arg Leu Asn Ile Glu Glu Leu Leu
    930                 935                 940                 
Lys His Met Tyr Glu Val Cys Gln Glu Met Gly Leu Met Glu Asp Leu
945                 950                 955                 960 
Leu Lys Leu Pro Phe Thr Asp Thr Glu Gln Glu Cys Leu Val Lys Phe
                965                 970                 975     
Leu Gln Ser Ser Ala Ser Val Gln Asn His Glu Phe Leu Leu Val His
            980                 985                 990         
His Leu Gln Arg Ala Asn Tyr Val Pro Ala Leu Lys Leu Asn Gln Thr
        995                 1000                1005            
Leu Lys Ile Asn Val Met Asn Asp Arg Asp Pro Arg Leu Arg Glu Arg
    1010                1015                1020                
Ser Leu Ala Arg Asn Ser Ile Leu Asp Gln Tyr Gly Lys Ile Leu Pro
1025                1030                1035                1040
Arg Val His Arg Lys Leu Ala Ile Glu Arg Ala Lys Pro Tyr His Leu
                1045                1050                1055    
Ser Thr Ser Ser Val Phe Arg Leu Val Ser Arg Pro Lys Pro Leu Ser
            1060                1065                1070        
Ala Val Pro Lys Gln Val Val Thr Gly Thr Val Leu Thr Arg Ser Val
        1075                1080                1085            
Phe Ile Asn Asn Val Leu Ser Lys Ile Gly Glu Val Trp Ala Ser Lys
    1090                1095                1100                
Glu Pro Ile Asn Ser Thr Thr Pro Phe Asn Ser Ser Lys Ile Glu Glu
1105                1110                1115                1120
Pro Ser Pro Ile Val Tyr Ser Leu Pro Ala Pro Glu Leu Pro Glu Ala
                1125                1130                1135    
Phe Phe Gly Thr Pro Ile Ser Lys Ala Ser Gln Lys Ile Ser Arg Leu
            1140                1145                1150        
Leu Asp Leu Val Val Gln Pro Val Pro Arg Pro Ser Gln Cys Ser Glu
        1155                1160                1165            
Ser Ile Gln Gln Ser Ser Met Lys Ser Pro Leu Tyr Leu Val Ser Arg
    1170                1175                1180                
Ser Leu Pro Ser Ser Ser Gln Leu Lys Gly Ser Pro Gln Ala Ile Ser
1185                1190                1195                1200
Arg Ala Ser Glu Leu His Leu Leu Glu Thr Pro Leu Val Val Lys Lys
                1205                1210                1215    
Ala Lys Ser Leu Ala Met Ser Val Thr Thr Ser Gly Phe Ser Glu Phe
            1220                1225                1230        
Thr Pro Gln Ser Ile Leu Arg Ser Thr Leu Arg Ser Thr Pro Leu Ala
        1235                1240                1245            
Ser Pro Ser Pro Ser Pro Gly Arg Ser Pro Gln Arg Leu Lys Glu Thr
    1250                1255                1260                
Arg Ile Ser Phe Val Glu Glu Asp Val His Pro Lys Trp Ile Pro Gly
1265                1270                1275                1280
Ala Ala Asp Asp Ser Lys Leu Glu Val Phe Thr Thr Pro Lys Lys Cys
                1285                1290                1295    
Ala Val Pro Val Glu Thr Glu Trp Leu Lys Ser Lys Asp Arg Thr Thr
            1300                1305                1310        
Ser Phe Phe Leu Asn Ser Pro Glu Lys Glu His Gln Glu Met Asp Glu
        1315                1320                1325            
Gly Ser Gln Ser Leu Glu Lys Leu Asp Val Ser Lys Gly Asn Ser Ser
    1330                1335                1340                
Val Ser Ile Thr Ser Asp Glu Thr Thr Leu Glu Tyr Gln Asp Ala Pro
1345                1350                1355                1360
Ser Pro Glu Asp Leu Glu Glu Thr Val Phe Thr Ala Ser Lys Pro Lys
                1365                1370                1375    
Ser Ser Ser Thr Ala Leu Thr Thr Asn Val Thr Glu Gln Thr Glu Lys
            1380                1385                1390        
Asp Gly Asp Lys Asp Val Phe Ala Ser Glu Val Thr Pro Ser Asp Leu
        1395                1400                1405            
Gln Lys Gln Met Gly Gln Phe Arg Arg Cys Arg Asn Lys Gly Ser Leu
    1410                1415                1420                
Thr Cys Ser Arg Gly Ile Phe Arg Ile Glu Ser Leu Lys Pro Arg Phe
1425                1430                1435                1440
Lys Ala Thr Glu Ala Ser Leu Cys Ala Pro Ser Val Tyr Glu Gly Lys
                1445                1450                1455    
Ile Phe Thr Gln Lys Ser Lys Val Pro Val Leu Asp Glu Gly Leu Thr
            1460                1465                1470        
Ser Val Glu Thr Tyr Thr Pro Ala Ile Arg Ala Asn Asp Asn Lys Ser
        1475                1480                1485            
Met Ala Asp Val Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr Ile Ser
    1490                1495                1500                
Glu Gly Pro Ile Val Ser Glu Arg Arg Leu Asn Gln Glu Val Ala Leu
1505                1510                1515                1520
Asn Leu Lys Glu Asp His Glu Val Glu Val Gly Val Leu Lys Glu Ser
                1525                1530                1535    
Val Asp Leu Pro Glu Glu Lys Leu Pro Ile Ser Asp Ser Pro Pro Asp
            1540                1545                1550        
Thr Gln Glu Ile His Val Ile Glu Gln Glu Lys Leu Glu Ala Gln Asp
        1555                1560                1565            
Ser Gly Glu Glu Ala Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser
    1570                1575                1580                
Gly Thr Leu Lys Leu Gln Tyr Asn Phe Asp Thr Ile Asp Gln Gln Phe
1585                1590                1595                1600
Cys Asp Leu Ala Asp Asn Lys Asp Thr Ala Glu Cys Asp Ile Ala Glu
                1605                1610                1615    
Val Asp Gly Glu Leu Phe Val Ala Gln Ser Asn Phe Thr Leu Ile Leu
            1620                1625                1630        
Glu Gly Glu Glu Gly Glu Val Glu Pro Gly Asp Phe Ala Ser Ser Asp
        1635                1640                1645            
Val Leu Pro Lys Ala Ala Asn Thr Ala Thr Glu Glu Lys Leu Val Cys
    1650                1655                1660                
Ser Gly Glu Asn Asp Asn His Gly Gln Ile Ala Asn Leu Pro Ser Ala
1665                1670                1675                1680
Val Thr Ser Asp Gln Lys Ser Gln Lys Val Asp Thr Leu Pro Tyr Val
                1685                1690                1695    
Pro Glu Pro Ile Lys Val Ala Ile Ala Glu Asn Leu Leu Asp Val Ile
            1700                1705                1710        
Lys Asp Thr Arg Ser Lys Glu Ile Thr Ser Asp Thr Met Glu Gln Ser
        1715                1720                1725            
Ile His Glu Thr Ile Pro Leu Val Ser Gln Asn Ile Met Cys Pro Thr
    1730                1735                1740                
Lys Leu Val Lys Ser Ala Phe Lys Thr Ala Gln Glu Thr Ser Thr Met
1745                1750                1755                1760
Thr Met Asn Val Ser Gln Val Asp Asp Val Val Ser Ser Lys Thr Arg
                1765                1770                1775    
Thr Arg Gly Gln Arg Ile Gln Asn Val Asn Val Lys Ser Ala Gln Gln
            1780                1785                1790        
Glu Ala Ser Ala Asp Val Ala Thr Pro Lys Met Pro Gly Gln Ser Val
        1795                1800                1805            
Arg Lys Lys Thr Arg Lys Ala Lys Glu Ile Ser Glu Ala Ser Glu Asn
    1810                1815                1820                
Ile Tyr Ser Asp Val Arg Gly Leu Ser Gln Asn Gln Gln Ile Pro Gln
1825                1830                1835                1840
Asn Ser Val Thr Pro Arg Arg Gly Arg Arg Lys Lys Glu Val Asn Gln
                1845                1850                1855    
Asp Ile Leu Glu Asn Thr Ser Ser Val Gly Gln Glu Leu Gln Ile Thr
            1860                1865                1870        
Thr Gly Arg Glu Ser Lys Arg Leu Lys Ser Ser Gln Leu Leu Glu Pro
        1875                1880                1885            
Ala Val Glu Glu Thr Thr Lys Lys Glu Val Lys Val Ser Ser Val Thr
    1890                1895                1900                
Lys Arg Thr Pro Arg Arg Ile Lys Arg Ser Val Glu Asn Gln Glu Ser
1905                1910                1915                1920
Val Glu Ile Ile Asn Asp Leu Lys Val Ser Thr Val Thr Ser Pro Ser
                1925                1930                1935    
Arg Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn
            1940                1945                1950        
Thr Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile
        1955                1960                1965            
Lys His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val
    1970                1975                1980                
Arg Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu
1985                1990                1995                2000
Phe Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile
                2005                2010                2015    
Asn Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser
            2020                2025                2030        
Pro Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn
        2035                2040                2045            
Thr Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly
    2050                2055                2060                
Lys Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser
2065                2070                2075                2080
Lys Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser
                2085                2090                2095    
Leu His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu
            2100                2105                2110        
Thr Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys
        2115                2120                2125            
Ser Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro
    2130                2135                2140                
Asp Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu
2145                2150                2155                2160
Val Pro Arg Glu Ala Lys Ala Lys Lys Ile Glu Val Pro Ala Gln Leu
                2165                2170                2175    
Lys Glu Leu Val Ser Asp Leu Ser Ser Gln Phe Val Ile Ser Pro Pro
            2180                2185                2190        
Ala Leu Arg Ser Arg Gln Lys Asn Thr Ser Asn Lys Asn Lys Leu Glu
        2195                2200                2205            
Asp Glu Leu Lys Asp Asp Ala Gln Ser Val Glu Thr Leu Gly Lys Pro
    2210                2215                2220                
Lys Ala Lys Arg Ile Arg Thr Ser Lys Thr Lys Gln Ala Ser Lys Asn
2225                2230                2235                2240
Thr Glu Lys Glu Ser Ala Trp Ser Pro Pro Pro Ile Glu Ile Arg Leu
                2245                2250                2255    
Ile Ser Pro Leu Ala Ser Pro Ala Asp Gly Val Lys Ser Lys Pro Arg
            2260                2265                2270        
Lys Thr Thr Glu Val Thr Gly Thr Gly Leu Gly Arg Asn Arg Lys Lys
        2275                2280                2285            
Leu Ser Ser Tyr Pro Lys Gln Ile Leu Arg Arg Lys Met Leu
    2290                2295                2300        


<210> 9058
<211> 2266
<212> PRT
<213> Homo sapiens

<400> 9058
Met Arg Asp Leu Arg Ala Gln Val Thr Ser Gly Leu Leu Pro Phe Pro
 1               5                  10                  15      
Glu Val Thr Leu Gln Ala Leu Gly Glu Asp Glu Ile Thr Leu Glu Ser
            20                  25                  30          
Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu Ala Cys Leu
        35                  40                  45              
Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Thr Gly Glu Arg
    50                  55                  60                  
Leu Ser Ala Tyr Arg Phe Ser Gly Val Asn Glu Gln Pro Pro Val Val
65                  70                  75                  80  
Leu Ala Val Lys Glu Phe Ser Trp Gln Lys Arg Thr Gly Leu Leu Ile
                85                  90                  95      
Gly Leu Glu Glu Thr Glu Gly Ser Val Leu Cys Leu Tyr Asp Leu Gly
            100                 105                 110         
Ile Ser Lys Val Val Lys Ala Val Val Leu Pro Gly Arg Val Thr Ala
        115                 120                 125             
Ile Glu Pro Ile Ile Asn His Gly Gly Ala Ser Ala Ser Thr Gln His
    130                 135                 140                 
Leu His Pro Ser Leu Arg Trp Leu Phe Gly Val Ala Ala Val Val Thr
145                 150                 155                 160 
Asp Val Gly Gln Ile Leu Leu Ile Asp Leu Cys Leu Asp Asp Leu Ser
                165                 170                 175     
Cys Asn Gln Asn Glu Val Glu Ala Ser Asp Leu Glu Val Leu Thr Gly
            180                 185                 190         
Ile Pro Ala Glu Val Pro His Ile Arg Glu Ser Val Met Arg Glu Gly
        195                 200                 205             
Arg His Leu Cys Phe Gln Leu Val Ser Pro Thr Gly Thr Ala Val Ser
    210                 215                 220                 
Thr Leu Ser Tyr Ile Ser Arg Thr Asn Gln Leu Ala Ala Gly Phe Ser
225                 230                 235                 240 
Asp Gly Tyr Leu Ala Leu Trp Asn Met Lys Ser Met Lys Arg Glu Tyr
                245                 250                 255     
Tyr Ile Gln Leu Glu Ser Gly Gln Val Pro Val Tyr Ala Val Thr Phe
            260                 265                 270         
Gln Glu Pro Glu Asn Asp Arg Arg Asn Cys Cys Tyr Leu Trp Ala Val
        275                 280                 285             
Gln Ser Thr Gln Asp Ser Glu Gly Asp Val Leu Ser Leu His Leu Leu
    290                 295                 300                 
Gln Leu Ala Phe Gly Asn Arg Lys Cys Leu Ala Ser Gly Gln Ile Leu
305                 310                 315                 320 
Tyr Glu Gly Leu Glu Tyr Cys Glu Glu Arg Tyr Thr Leu Asp Leu Thr
                325                 330                 335     
Gly Gly Met Phe Pro Leu Arg Gly Gln Thr Ser Asn Thr Lys Leu Leu
            340                 345                 350         
Gly Cys Gln Ser Ile Glu Lys Phe Arg Ser His Gly Asp Arg Glu Glu
        355                 360                 365             
Gly Val Asn Glu Ala Leu Ser Pro Asp Thr Ser Val Ser Val Phe Thr
    370                 375                 380                 
Trp Gln Val Asn Ile Tyr Gly Gln Gly Lys Pro Ser Val Tyr Leu Gly
385                 390                 395                 400 
Leu Phe Asp Ile Asn Arg Trp Tyr His Ala Gln Met Pro Asp Ser Leu
                405                 410                 415     
Arg Ser Gly Glu Tyr Leu His Asn Cys Ser Tyr Phe Ala Leu Trp Ser
            420                 425                 430         
Leu Glu Ser Val Val Ser Arg Thr Ser Pro His Gly Ile Leu Asp Ile
        435                 440                 445             
Leu Val His Glu Arg Ser Leu Asn Arg Gly Val Pro Pro Ser Tyr Pro
    450                 455                 460                 
Pro Pro Glu Gln Phe Phe Asn Pro Ser Thr Tyr Asn Phe Asp Ala Thr
465                 470                 475                 480 
Cys Leu Leu Asn Ser Gly Val Val His Leu Thr Cys Thr Gly Phe Gln
                485                 490                 495     
Lys Glu Thr Leu Thr Phe Leu Lys Lys Ser Gly Pro Ser Leu Asn Glu
            500                 505                 510         
Leu Ile Pro Asp Gly Tyr Asn Arg Cys Leu Val Ala Gly Leu Leu Ser
        515                 520                 525             
Pro Arg Phe Val Asp Val Gln Pro Ser Ser Leu Ser Gln Glu Glu Gln
    530                 535                 540                 
Leu Glu Ala Ile Leu Ser Ala Ala Ile Gln Thr Ser Ser Leu Gly Leu
545                 550                 555                 560 
Leu Thr Gly Tyr Ile Arg Arg Trp Ile Thr Glu Glu Gln Pro Asn Ser
                565                 570                 575     
Ala Thr Asn Leu Arg Phe Val Leu Glu Trp Thr Trp Asn Lys Val Val
            580                 585                 590         
Leu Thr Lys Glu Glu Phe Asp Arg Leu Cys Val Pro Leu Phe Asp Gly
        595                 600                 605             
Ser Cys His Phe Met Asp Pro Gln Thr Ile Gln Ser Ile Gln Gln Cys
    610                 615                 620                 
Tyr Leu Leu Leu Ser Asn Leu Asn Ile Val Leu Ser Cys Phe Ala Ser
625                 630                 635                 640 
Glu Ala Arg Glu Ile Ala Glu Arg Gly Leu Ile Asp Leu Ser Asn Lys
                645                 650                 655     
Phe Val Val Ser His Leu Ile Cys Gln Tyr Ala Gln Val Val Leu Trp
            660                 665                 670         
Phe Ser His Ser Gly Leu Leu Pro Glu Gly Ile Asp Asp Ser Val Gln
        675                 680                 685             
Leu Ser Arg Leu Cys Tyr Asn Tyr Pro Val Ile Gln Asn Tyr Tyr Thr
    690                 695                 700                 
Ser Arg Arg Gln Lys Phe Glu Arg Leu Ser Arg Gly Lys Trp Asn Pro
705                 710                 715                 720 
Asp Cys Leu Met Ile Asp Gly Leu Val Ser Gln Leu Gly Glu Arg Ile
                725                 730                 735     
Glu Lys Leu Trp Lys Arg Asp Glu Gly Gly Thr Gly Lys Tyr Pro Pro
            740                 745                 750         
Ala Ser Leu His Ala Val Leu Asp Met Tyr Leu Leu Asp Gly Val Thr
        755                 760                 765             
Glu Ala Ala Lys His Ser Ile Thr Ile Tyr Leu Leu Leu Asp Ile Met
    770                 775                 780                 
Tyr Ser Phe Pro Asn Lys Thr Asp Thr Pro Ile Glu Ser Phe Pro Thr
785                 790                 795                 800 
Val Phe Ala Ile Ser Trp Gly Gln Val Lys Leu Ile Gln Gly Phe Trp
                805                 810                 815     
Leu Ile Asp His Asn Asp Tyr Glu Ser Gly Leu Asp Leu Leu Phe His
            820                 825                 830         
Pro Ala Thr Ala Lys Pro Leu Ser Trp Gln His Ser Lys Ile Ile Gln
        835                 840                 845             
Ala Phe Met Ser Gln Gly Glu His Arg Gln Ala Leu Arg Tyr Ile Gln
    850                 855                 860                 
Thr Met Lys Pro Thr Val Ser Ser Gly Asn Asp Val Ile Leu His Leu
865                 870                 875                 880 
Thr Val Leu Leu Phe Asn Arg Cys Met Val Glu Ala Trp Asn Phe Leu
                885                 890                 895     
Arg Gln His Cys Asn Arg Leu Asn Ile Glu Glu Leu Leu Lys His Met
            900                 905                 910         
Tyr Glu Val Cys Gln Glu Met Gly Leu Met Glu Asp Leu Leu Lys Leu
        915                 920                 925             
Pro Phe Thr Asp Thr Glu Gln Glu Cys Leu Val Lys Phe Leu Gln Ser
    930                 935                 940                 
Ser Ala Ser Val Gln Asn His Glu Phe Leu Leu Val His His Leu Gln
945                 950                 955                 960 
Arg Ala Asn Tyr Val Pro Ala Leu Lys Leu Asn Gln Thr Leu Lys Ile
                965                 970                 975     
Asn Val Met Asn Asp Arg Asp Pro Arg Leu Arg Glu Arg Ser Leu Ala
            980                 985                 990         
Arg Asn Ser Ile Leu Asp Gln Tyr Gly Lys Ile Leu Pro Arg Val His
        995                 1000                1005            
Arg Lys Leu Ala Ile Glu Arg Ala Lys Pro Tyr His Leu Ser Thr Ser
    1010                1015                1020                
Ser Val Phe Arg Leu Val Ser Arg Pro Lys Pro Leu Ser Ala Val Pro
1025                1030                1035                1040
Lys Gln Val Val Thr Gly Thr Val Leu Thr Arg Ser Val Phe Ile Asn
                1045                1050                1055    
Asn Val Leu Ser Lys Ile Gly Glu Val Trp Ala Ser Lys Glu Pro Ile
            1060                1065                1070        
Asn Ser Thr Thr Pro Phe Asn Ser Ser Lys Ile Glu Glu Pro Ser Pro
        1075                1080                1085            
Ile Val Tyr Ser Leu Pro Ala Pro Glu Leu Pro Glu Ala Phe Phe Gly
    1090                1095                1100                
Thr Pro Ile Ser Lys Ala Ser Gln Lys Ile Ser Arg Leu Leu Asp Leu
1105                1110                1115                1120
Val Val Gln Pro Val Pro Arg Pro Ser Gln Cys Ser Glu Phe Ile Gln
                1125                1130                1135    
Gln Ser Ser Met Lys Ser Pro Leu Tyr Leu Val Ser Arg Ser Leu Pro
            1140                1145                1150        
Ser Ser Ser Gln Leu Lys Gly Ser Pro Gln Ala Ile Ser Arg Ala Ser
        1155                1160                1165            
Glu Leu His Leu Leu Glu Thr Pro Leu Val Val Lys Lys Ala Lys Ser
    1170                1175                1180                
Leu Ala Met Ser Val Thr Thr Ser Gly Phe Ser Glu Phe Thr Pro Gln
1185                1190                1195                1200
Ser Ile Leu Arg Ser Thr Pro Arg Ser Thr Pro Leu Ala Ser Pro Ser
                1205                1210                1215    
Pro Ser Pro Gly Arg Ser Pro Gln Arg Leu Lys Glu Thr Arg Ile Ser
            1220                1225                1230        
Phe Val Glu Glu Asp Val His Pro Lys Trp Ile Pro Gly Ala Ala Asp
        1235                1240                1245            
Asp Ser Lys Leu Glu Val Phe Thr Thr Pro Lys Lys Cys Ala Val Pro
    1250                1255                1260                
Val Glu Thr Glu Trp Pro Lys Ser Lys Asp Arg Thr Thr Ser Phe Phe
1265                1270                1275                1280
Leu Asn Ser Pro Glu Lys Glu His Gln Glu Met Asp Glu Gly Ser Gln
                1285                1290                1295    
Ser Leu Glu Lys Leu Asp Val Ser Lys Gly Asn Ser Ser Val Ser Ile
            1300                1305                1310        
Thr Ser Asp Glu Thr Thr Leu Glu Tyr Gln Asp Ala Pro Ser Pro Glu
        1315                1320                1325            
Asp Leu Glu Glu Thr Val Phe Thr Ala Ser Lys Pro Lys Ser Ser Ser
    1330                1335                1340                
Thr Ala Leu Thr Thr Asn Val Thr Glu Gln Thr Glu Lys Asp Gly Asp
1345                1350                1355                1360
Lys Asp Val Phe Ala Ser Glu Val Thr Pro Ser Asp Leu Gln Lys Gln
                1365                1370                1375    
Met Gly Asn Leu Glu Asp Ala Glu Thr Lys Asp Leu Leu Val Ala Ala
            1380                1385                1390        
Glu Ala Phe Ser Glu Leu Asn His Leu Ser Pro Val Gln Gly Thr Glu
        1395                1400                1405            
Ala Ser Leu Cys Ala Pro Ser Val Tyr Glu Gly Lys Ile Phe Thr Gln
    1410                1415                1420                
Lys Ser Lys Val Pro Val Leu Asp Glu Gly Leu Thr Ser Val Glu Thr
1425                1430                1435                1440
Tyr Thr Pro Ala Ile Arg Ala Asn Asp Asn Lys Ser Met Ala Asp Val
                1445                1450                1455    
Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr Ile Ser Glu Gly Pro Ile
            1460                1465                1470        
Val Ser Glu Arg Arg Leu Asn Gln Glu Val Ala Leu Asn Leu Lys Glu
        1475                1480                1485            
Asp His Glu Val Glu Val Gly Val Leu Lys Glu Ser Val Asp Leu Pro
    1490                1495                1500                
Glu Glu Lys Leu Pro Ile Ser Asp Ser Pro Pro Asp Thr Gln Glu Ile
1505                1510                1515                1520
His Val Ile Glu Gln Glu Lys Leu Glu Ala Gln Asp Ser Gly Glu Glu
                1525                1530                1535    
Ala Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly Thr Leu Lys
            1540                1545                1550        
Leu Gln Tyr Asn Phe Asp Thr Ile Asp Gln Gln Phe Cys Asp Leu Ala
        1555                1560                1565            
Asp Asn Lys Asp Thr Ala Glu Cys Asp Ile Ala Glu Val Asp Gly Glu
    1570                1575                1580                
Leu Phe Val Ala Gln Ser Asn Phe Thr Leu Ile Leu Glu Gly Glu Glu
1585                1590                1595                1600
Gly Glu Val Glu Pro Gly Asp Phe Ala Ser Ser Asp Val Leu Pro Lys
                1605                1610                1615    
Ala Ala Asn Thr Ala Thr Glu Glu Lys Leu Val Cys Ser Gly Glu Asn
            1620                1625                1630        
Asp Asn His Gly Gln Ile Ala Asn Leu Pro Ser Ala Val Thr Ser Asp
        1635                1640                1645            
Gln Lys Ser Gln Lys Val Asp Thr Leu Pro Tyr Val Pro Glu Pro Ile
    1650                1655                1660                
Lys Val Ala Ile Ala Glu Asn Leu Leu Asp Val Ile Lys Asp Thr Arg
1665                1670                1675                1680
Ser Lys Glu Ile Thr Ser Asp Thr Met Glu Gln Ser Ile His Glu Thr
                1685                1690                1695    
Ile Pro Leu Val Ser Gln Asn Ile Met Cys Pro Thr Lys Leu Val Lys
            1700                1705                1710        
Ser Ala Phe Lys Thr Ala Gln Glu Thr Ser Thr Met Thr Met Asn Val
        1715                1720                1725            
Ser Gln Val Asp Asp Val Val Ser Ser Lys Thr Arg Thr Arg Gly Gln
    1730                1735                1740                
Arg Ile Gln Asn Val Asn Val Lys Ser Ala Gln Gln Glu Ala Ser Ala
1745                1750                1755                1760
Asp Val Ala Thr Pro Lys Met Pro Gly Gln Ser Val Arg Lys Lys Thr
                1765                1770                1775    
Arg Lys Ala Lys Glu Ile Ser Glu Ala Ser Glu Asn Ile Tyr Ser Asp
            1780                1785                1790        
Val Arg Gly Leu Phe Gln Asn Gln Gln Ile Pro Gln Asn Ser Val Thr
        1795                1800                1805            
Pro Arg Arg Gly Arg Arg Lys Lys Glu Val Asn Gln Asp Ile Leu Glu
    1810                1815                1820                
Asn Thr Ser Ser Val Glu Gln Glu Leu Gln Ile Thr Thr Gly Arg Glu
1825                1830                1835                1840
Ser Lys Arg Leu Lys Ser Ser Gln Leu Leu Glu Pro Ala Val Glu Glu
                1845                1850                1855    
Thr Thr Lys Lys Glu Val Lys Val Ser Ser Val Thr Lys Arg Thr Pro
            1860                1865                1870        
Arg Arg Ile Lys Arg Ser Val Glu Asn Gln Glu Ser Val Glu Ile Ile
        1875                1880                1885            
Asn Asp Leu Lys Val Ser Thr Val Thr Ser Pro Ser Arg Met Ile Arg
    1890                1895                1900                
Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr Gly Asn Lys
1905                1910                1915                1920
Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys His Val Arg
                1925                1930                1935    
Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg Glu Asp Ser
            1940                1945                1950        
Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe Asp Met Ser
        1955                1960                1965            
Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn Pro Ser Glu
    1970                1975                1980                
Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro Lys Lys Lys
1985                1990                1995                2000
Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr Pro Ala Lys
                2005                2010                2015    
Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys Ser Ile Leu
            2020                2025                2030        
Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys Lys Lys Leu
        2035                2040                2045            
Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu His Ser Val
    2050                2055                2060                
Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr Asn Glu Gln
2065                2070                2075                2080
Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser Ser Arg Ser
                2085                2090                2095    
Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp Leu Ser Glu
            2100                2105                2110        
Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val Pro Arg Lys
        2115                2120                2125            
Ala Lys Ala Lys Lys Ile Glu Val Pro Ala Gln Leu Lys Glu Leu Val
    2130                2135                2140                
Ser Asp Leu Ser Ser Gln Phe Val Ile Ser Pro Pro Ala Leu Arg Ser
2145                2150                2155                2160
Arg Gln Lys Asn Thr Ser Asn Lys Asn Lys Leu Glu Asp Glu Leu Lys
                2165                2170                2175    
Asp Asp Ala Gln Ser Val Glu Thr Leu Gly Lys Pro Lys Ala Lys Arg
            2180                2185                2190        
Ile Arg Thr Ser Lys Thr Lys Gln Ala Ser Lys Asn Thr Glu Lys Glu
        2195                2200                2205            
Ser Ala Trp Ser Leu Pro Pro Ile Glu Ile Arg Leu Ile Ser Pro Leu
    2210                2215                2220                
Ala Ser Pro Ala Asp Gly Val Lys Ser Lys Pro Arg Lys Thr Thr Glu
2225                2230                2235                2240
Val Thr Gly Thr Gly Leu Gly Arg Asn Arg Lys Lys Leu Ser Ser Tyr
                2245                2250                2255    
Pro Lys Gln Ile Leu Arg Arg Lys Met Leu
            2260                2265    


<210> 9059
<211> 1189
<212> PRT
<213> Homo sapiens

<400> 9059
Met Lys Ser Glu Glu Gln Pro Met Asp Leu Glu Asn Arg Ser Thr Ala
 1               5                  10                  15      
Asn Val Leu Glu Glu Thr Thr Val Lys Lys Glu Lys Glu Asp Glu Lys
            20                  25                  30          
Glu Leu Val Lys Leu Pro Val Ile Val Lys Leu Glu Lys Pro Leu Pro
        35                  40                  45              
Glu Asn Glu Glu Lys Lys Ile Ile Lys Glu Glu Ser Asp Ser Phe Lys
    50                  55                  60                  
Glu Asn Val Lys Pro Ile Lys Val Glu Val Lys Glu Cys Arg Ala Asp
65                  70                  75                  80  
Pro Lys Asp Thr Lys Ser Ser Met Glu Lys Pro Val Ala Gln Glu Pro
                85                  90                  95      
Glu Arg Ile Glu Phe Gly Gly Asn Ile Lys Ser Ser His Glu Ile Thr
            100                 105                 110         
Glu Lys Ser Thr Glu Glu Thr Glu Lys Leu Lys Asn Asp Gln Gln Ala
        115                 120                 125             
Lys Ile Pro Leu Lys Lys Arg Glu Ile Lys Leu Ser Asp Asp Phe Asp
    130                 135                 140                 
Ser Pro Val Lys Gly Pro Leu Cys Lys Ser Val Thr Pro Thr Lys Glu
145                 150                 155                 160 
Phe Leu Lys Asp Glu Ile Lys Gln Glu Glu Glu Thr Cys Lys Arg Ile
                165                 170                 175     
Ser Thr Ile Thr Ala Leu Gly His Glu Gly Lys Gln Leu Val Asn Gly
            180                 185                 190         
Glu Val Ser Asp Glu Arg Val Ala Pro Asn Phe Lys Thr Glu Pro Ile
        195                 200                 205             
Glu Thr Lys Phe Tyr Glu Thr Lys Glu Glu Ser Tyr Ser Pro Ser Lys
    210                 215                 220                 
Asp Arg Asn Ile Ile Thr Glu Gly Asn Gly Thr Glu Ser Leu Asn Ser
225                 230                 235                 240 
Val Ile Thr Ser Met Lys Thr Gly Glu Leu Glu Lys Glu Thr Ala Pro
                245                 250                 255     
Leu Arg Lys Asp Ala Asp Ser Ser Ile Ser Val Leu Glu Ile His Ser
            260                 265                 270         
Gln Lys Ala Gln Ile Glu Glu Pro Asp Pro Pro Glu Met Glu Thr Ser
        275                 280                 285             
Leu Asp Ser Ser Glu Met Ala Lys Asp Leu Ser Ser Lys Thr Ala Leu
    290                 295                 300                 
Ser Ser Thr Glu Ser Cys Thr Met Lys Gly Glu Glu Lys Ser Pro Lys
305                 310                 315                 320 
Thr Lys Lys Asp Lys Arg Pro Pro Ile Leu Glu Cys Leu Glu Lys Leu
                325                 330                 335     
Glu Lys Ser Lys Lys Thr Phe Leu Asp Lys Asp Ala Gln Arg Leu Ser
            340                 345                 350         
Pro Ile Pro Glu Glu Val Pro Lys Ser Thr Leu Glu Ser Glu Lys Pro
        355                 360                 365             
Gly Ser Pro Glu Ala Ala Glu Thr Ser Pro Pro Ser Asn Ile Ile Asp
    370                 375                 380                 
His Cys Glu Lys Leu Ala Ser Glu Lys Glu Val Val Glu Cys Gln Ser
385                 390                 395                 400 
Thr Ser Thr Val Gly Gly Gln Ser Val Lys Lys Val Asp Leu Glu Thr
                405                 410                 415     
Leu Lys Glu Asp Ser Glu Phe Thr Lys Val Glu Met Asp Asn Leu Asp
            420                 425                 430         
Asn Ala Gln Thr Ser Gly Ile Glu Glu Pro Ser Glu Thr Lys Gly Ser
        435                 440                 445             
Met Gln Lys Ser Lys Phe Lys Tyr Lys Leu Val Pro Glu Glu Glu Thr
    450                 455                 460                 
Thr Ala Ser Glu Asn Thr Glu Ile Thr Ser Glu Arg Gln Lys Glu Gly
465                 470                 475                 480 
Ile Lys Leu Thr Ile Arg Ile Ser Ser Arg Lys Lys Lys Pro Asp Ser
                485                 490                 495     
Pro Pro Lys Val Leu Glu Pro Glu Asn Lys Gln Glu Lys Thr Glu Lys
            500                 505                 510         
Glu Glu Glu Lys Thr Asn Val Gly Arg Thr Leu Arg Arg Ser Pro Arg
        515                 520                 525             
Ile Ser Arg Pro Thr Ala Lys Val Ala Glu Ile Arg Asp Gln Lys Ala
    530                 535                 540                 
Asp Lys Lys Arg Gly Glu Gly Glu Asp Glu Val Glu Glu Glu Ser Thr
545                 550                 555                 560 
Ala Leu Gln Lys Thr Asp Lys Lys Glu Ile Leu Lys Lys Ser Glu Lys
                565                 570                 575     
Asp Thr Asn Ser Lys Val Ser Lys Val Lys Pro Lys Gly Lys Val Arg
            580                 585                 590         
Trp Thr Gly Ser Arg Thr Arg Gly Arg Trp Lys Tyr Ser Ser Asn Asp
        595                 600                 605             
Glu Ser Glu Gly Ser Gly Ser Glu Lys Ser Ser Ala Ala Ser Glu Glu
    610                 615                 620                 
Glu Glu Glu Lys Glu Ser Glu Glu Ala Ile Leu Ala Asp Asp Asp Glu
625                 630                 635                 640 
Pro Cys Lys Lys Cys Gly Leu Pro Asn His Pro Glu Leu Ile Leu Leu
                645                 650                 655     
Cys Asp Ser Cys Asp Ser Gly Tyr His Thr Ala Cys Leu Arg Pro Pro
            660                 665                 670         
Leu Met Ile Ile Pro Asp Gly Glu Trp Phe Cys Pro Pro Cys Gln His
        675                 680                 685             
Lys Leu Leu Cys Glu Lys Leu Glu Glu Gln Leu Gln Asp Leu Asp Val
    690                 695                 700                 
Ala Leu Lys Lys Lys Glu Arg Ala Glu Arg Arg Lys Glu Arg Leu Val
705                 710                 715                 720 
Tyr Val Gly Ile Ser Ile Glu Asn Ile Ile Pro Pro Gln Glu Pro Asp
                725                 730                 735     
Phe Ser Glu Asp Gln Glu Glu Lys Lys Lys Asp Ser Lys Lys Ser Lys
            740                 745                 750         
Ala Asn Leu Leu Glu Arg Arg Ser Thr Arg Thr Arg Lys Cys Ile Ser
        755                 760                 765             
Tyr Arg Phe Asp Glu Phe Asp Glu Ala Ile Asp Glu Ala Ile Glu Asp
    770                 775                 780                 
Asp Ile Lys Glu Ala Asp Gly Gly Gly Val Gly Arg Gly Lys Asp Ile
785                 790                 795                 800 
Ser Thr Ile Thr Gly His Arg Gly Lys Asp Ile Ser Thr Ile Leu Asp
                805                 810                 815     
Glu Glu Arg Lys Glu Asn Lys Arg Pro Gln Arg Ala Ala Ala Ala Arg
            820                 825                 830         
Arg Lys Lys Arg Arg Arg Leu Asn Asp Leu Asp Ser Asp Ser Asn Leu
        835                 840                 845             
Asp Glu Glu Glu Ser Glu Asp Glu Phe Lys Ile Ser Asp Gly Ser Gln
    850                 855                 860                 
Asp Glu Phe Val Val Ser Asp Glu Asn Pro Asp Glu Ser Glu Glu Asp
865                 870                 875                 880 
Pro Pro Ser Asn Glu Asp Ser Asp Thr Asp Phe Cys Ser Arg Arg Leu
                885                 890                 895     
Arg Arg His Pro Ser Arg Pro Met Arg Gln Ser Arg Arg Leu Arg Arg
            900                 905                 910         
Lys Thr Pro Lys Lys Lys Tyr Ser Asp Asp Asp Glu Glu Glu Glu Ser
        915                 920                 925             
Glu Glu Asn Ser Arg Asp Ser Glu Ser Asp Phe Ser Asp Asp Phe Ser
    930                 935                 940                 
Asp Asp Phe Val Glu Thr Arg Arg Arg Arg Ser Arg Arg Asn Gln Lys
945                 950                 955                 960 
Arg Gln Ile Asn Tyr Lys Glu Asp Ser Glu Ser Asp Gly Ser Gln Lys
                965                 970                 975     
Ser Leu Arg Arg Gly Lys Glu Ile Arg Arg Val His Lys Arg Arg Leu
            980                 985                 990         
Ser Ser Ser Glu Ser Glu Glu Ser Tyr Leu Ser Lys Asn Ser Glu Asp
        995                 1000                1005            
Asp Glu Leu Ala Lys Glu Ser Lys Arg Ser Val Arg Lys Arg Gly Arg
    1010                1015                1020                
Ser Thr Asp Glu Tyr Ser Glu Ala Asp Glu Glu Glu Glu Glu Glu Glu
1025                1030                1035                1040
Gly Lys Pro Ser Arg Lys Arg Leu His Arg Ile Glu Thr Asp Glu Glu
                1045                1050                1055    
Glu Ser Cys Asp Asn Ala His Gly Asp Ala Asn Gln Pro Ala Arg Asp
            1060                1065                1070        
Ser Gln Pro Arg Val Leu Pro Ser Glu Gln Glu Ser Thr Lys Lys Pro
        1075                1080                1085            
Tyr Arg Ile Glu Ser Asp Glu Glu Glu Asp Phe Glu Asn Val Gly Lys
    1090                1095                1100                
Val Gly Ser Pro Leu Asp Tyr Ser Leu Val Asp Leu Pro Ser Thr Asn
1105                1110                1115                1120
Gly Gln Ser Pro Gly Lys Ala Ile Glu Asn Leu Ile Gly Lys Pro Thr
                1125                1130                1135    
Glu Lys Ser Gln Thr Pro Lys Asp Asn Ser Thr Ala Ser Ala Ser Leu
            1140                1145                1150        
Ala Ser Asn Gly Thr Ser Gly Gly Gln Glu Ala Gly Ala Pro Glu Glu
        1155                1160                1165            
Glu Glu Asp Glu Leu Leu Arg Val Thr Asp Leu Val Asp Tyr Val Cys
    1170                1175                1180                
Asn Ser Glu Gln Leu
1185                


<210> 9060
<211> 1441
<212> PRT
<213> Homo sapiens

<400> 9060
Met Ala Thr Ala Ala Ala Ala Ala Ala Val Met Ala Pro Pro Gly Cys
 1               5                  10                  15      
Pro Gly Ser Cys Pro Asn Phe Ala Val Val Cys Ser Phe Leu Glu Arg
            20                  25                  30          
Tyr Gly Pro Leu Leu Asp Leu Pro Glu Leu Pro Phe Pro Glu Leu Glu
        35                  40                  45              
Arg Val Leu Gln Ala Pro Pro Pro Asp Val Gly Asn Gly Glu Val Pro
    50                  55                  60                  
Lys Glu Leu Val Glu Leu His Leu Lys Leu Met Arg Lys Ile Gly Lys
65                  70                  75                  80  
Ser Val Thr Ala Asp Arg Trp Glu Lys Tyr Leu Ile Lys Ile Cys Gln
                85                  90                  95      
Glu Phe Asn Ser Thr Trp Ala Trp Glu Met Glu Lys Lys Gly Tyr Leu
            100                 105                 110         
Glu Met Ser Val Glu Cys Lys Leu Ala Leu Leu Lys Tyr Leu Cys Glu
        115                 120                 125             
Cys Gln Phe Asp Asp Asn Leu Lys Phe Lys Asn Ile Ile Asn Glu Glu
    130                 135                 140                 
Asp Ala Asp Thr Met Arg Leu Gln Pro Ile Gly Arg Asp Lys Asp Gly
145                 150                 155                 160 
Leu Met Tyr Trp Tyr Gln Leu Asp Gln Asp His Asn Val Arg Met Tyr
                165                 170                 175     
Ile Glu Glu Gln Asp Asp Gln Asp Gly Ser Ser Trp Lys Cys Ile Val
            180                 185                 190         
Arg Asn Arg Asn Glu Leu Ala Glu Thr Leu Ala Leu Leu Lys Ala Gln
        195                 200                 205             
Ile Asp Pro Val Leu Leu Lys Asn Ser Ser Gln Gln Asp Asn Ser Ser
    210                 215                 220                 
Arg Glu Ser Pro Ser Leu Glu Asp Glu Glu Thr Lys Lys Glu Glu Glu
225                 230                 235                 240 
Thr Pro Lys Gln Glu Glu Gln Lys Glu Ser Glu Lys Met Lys Ser Glu
                245                 250                 255     
Glu Gln Pro Met Asp Leu Glu Asn Arg Ser Thr Ala Asn Val Leu Glu
            260                 265                 270         
Glu Thr Thr Val Lys Lys Glu Lys Glu Asp Glu Lys Glu Leu Val Lys
        275                 280                 285             
Leu Pro Val Ile Val Lys Leu Glu Lys Pro Leu Pro Glu Asn Glu Glu
    290                 295                 300                 
Lys Lys Ile Ile Lys Glu Glu Ser Asp Ser Phe Lys Glu Asn Val Lys
305                 310                 315                 320 
Pro Ile Lys Val Glu Val Lys Glu Cys Arg Ala Asp Pro Lys Asp Thr
                325                 330                 335     
Lys Ser Ser Met Glu Lys Pro Val Ala Gln Glu Pro Glu Arg Ile Glu
            340                 345                 350         
Phe Gly Gly Asn Ile Lys Ser Ser His Glu Ile Thr Glu Lys Ser Thr
        355                 360                 365             
Glu Glu Thr Glu Lys Leu Lys Asn Asp Gln Gln Ala Lys Ile Pro Leu
    370                 375                 380                 
Lys Lys Arg Glu Ile Lys Leu Ser Asp Asp Phe Asp Ser Pro Val Lys
385                 390                 395                 400 
Gly Pro Leu Cys Lys Ser Val Thr Pro Thr Lys Glu Phe Leu Lys Asp
                405                 410                 415     
Glu Ile Lys Gln Glu Glu Glu Thr Cys Lys Arg Ile Ser Thr Ile Thr
            420                 425                 430         
Ala Leu Gly His Glu Gly Lys Gln Leu Val Asn Gly Glu Val Ser Asp
        435                 440                 445             
Glu Arg Val Ala Pro Asn Phe Lys Thr Glu Pro Ile Glu Thr Lys Phe
    450                 455                 460                 
Tyr Glu Thr Lys Glu Glu Ser Tyr Ser Pro Ser Lys Asp Arg Asn Ile
465                 470                 475                 480 
Ile Thr Glu Gly Asn Gly Thr Glu Ser Leu Asn Ser Val Ile Thr Ser
                485                 490                 495     
Met Lys Thr Gly Glu Leu Glu Lys Glu Thr Ala Pro Leu Arg Lys Asp
            500                 505                 510         
Ala Asp Ser Ser Ile Ser Val Leu Glu Ile His Ser Gln Lys Ala Gln
        515                 520                 525             
Ile Glu Glu Pro Asp Pro Pro Glu Met Glu Thr Ser Leu Asp Ser Ser
    530                 535                 540                 
Glu Met Ala Lys Asp Leu Ser Ser Lys Thr Ala Leu Ser Ser Thr Glu
545                 550                 555                 560 
Ser Cys Thr Met Lys Gly Glu Glu Lys Ser Pro Lys Thr Lys Lys Asp
                565                 570                 575     
Lys Arg Pro Pro Ile Leu Glu Cys Leu Glu Lys Leu Glu Lys Ser Lys
            580                 585                 590         
Lys Thr Phe Leu Asp Lys Asp Ala Gln Arg Leu Ser Pro Ile Pro Glu
        595                 600                 605             
Glu Val Pro Lys Ser Thr Leu Glu Ser Glu Lys Pro Gly Ser Pro Glu
    610                 615                 620                 
Ala Ala Glu Thr Ser Pro Pro Ser Asn Ile Ile Asp His Cys Glu Lys
625                 630                 635                 640 
Leu Ala Ser Glu Lys Glu Val Val Glu Cys Gln Ser Thr Ser Thr Val
                645                 650                 655     
Gly Gly Gln Ser Val Lys Lys Val Asp Leu Glu Thr Leu Lys Glu Asp
            660                 665                 670         
Ser Glu Phe Thr Lys Val Glu Met Asp Asn Leu Asp Asn Ala Gln Thr
        675                 680                 685             
Ser Gly Ile Glu Glu Pro Ser Glu Thr Lys Gly Ser Met Gln Lys Ser
    690                 695                 700                 
Lys Phe Lys Tyr Lys Leu Val Pro Glu Glu Glu Thr Thr Ala Ser Glu
705                 710                 715                 720 
Asn Thr Glu Ile Thr Ser Glu Arg Gln Lys Glu Gly Ile Lys Leu Thr
                725                 730                 735     
Ile Arg Ile Ser Ser Arg Lys Lys Lys Pro Asp Ser Pro Pro Lys Val
            740                 745                 750         
Leu Glu Pro Glu Asn Lys Gln Glu Lys Thr Glu Lys Glu Glu Glu Lys
        755                 760                 765             
Thr Asn Val Gly Arg Thr Leu Arg Arg Ser Pro Arg Ile Ser Arg Pro
    770                 775                 780                 
Thr Ala Lys Val Ala Glu Ile Arg Asp Gln Lys Ala Asp Lys Lys Arg
785                 790                 795                 800 
Gly Glu Gly Glu Asp Glu Val Glu Glu Glu Ser Thr Ala Leu Gln Lys
                805                 810                 815     
Thr Asp Lys Lys Glu Ile Leu Lys Lys Ser Glu Lys Asp Thr Asn Ser
            820                 825                 830         
Lys Val Ser Lys Val Lys Pro Lys Gly Lys Val Arg Trp Thr Gly Ser
        835                 840                 845             
Arg Thr Arg Gly Arg Trp Lys Tyr Ser Ser Asn Asp Glu Ser Glu Gly
    850                 855                 860                 
Ser Gly Ser Glu Lys Ser Ser Ala Ala Ser Glu Glu Glu Glu Glu Lys
865                 870                 875                 880 
Glu Ser Glu Glu Ala Ile Leu Ala Asp Asp Asp Glu Pro Cys Lys Lys
                885                 890                 895     
Cys Gly Leu Pro Asn His Pro Glu Leu Ile Leu Leu Cys Asp Ser Cys
            900                 905                 910         
Asp Ser Gly Tyr His Thr Ala Cys Leu Arg Pro Pro Leu Met Ile Ile
        915                 920                 925             
Pro Asp Gly Glu Trp Phe Cys Pro Pro Cys Gln His Lys Leu Leu Cys
    930                 935                 940                 
Glu Lys Leu Glu Glu Gln Leu Gln Asp Leu Asp Val Ala Leu Lys Lys
945                 950                 955                 960 
Lys Glu Arg Ala Glu Arg Arg Lys Glu Arg Leu Val Tyr Val Gly Ile
                965                 970                 975     
Ser Ile Glu Asn Ile Ile Pro Pro Gln Glu Pro Asp Phe Ser Glu Asp
            980                 985                 990         
Gln Glu Glu Lys Lys Lys Asp Ser Lys Lys Ser Lys Ala Asn Leu Leu
        995                 1000                1005            
Glu Arg Arg Ser Thr Arg Thr Arg Lys Cys Ile Ser Tyr Arg Phe Asp
    1010                1015                1020                
Glu Phe Asp Glu Ala Ile Asp Glu Ala Ile Glu Asp Asp Ile Lys Glu
1025                1030                1035                1040
Ala Asp Gly Gly Gly Val Gly Arg Gly Lys Asp Ile Ser Thr Ile Thr
                1045                1050                1055    
Gly His Arg Gly Lys Asp Ile Ser Thr Ile Leu Asp Glu Glu Arg Lys
            1060                1065                1070        
Glu Asn Lys Arg Pro Gln Arg Ala Ala Ala Ala Arg Arg Lys Lys Arg
        1075                1080                1085            
Arg Arg Leu Asn Asp Leu Asp Ser Asp Ser Asn Leu Asp Glu Glu Glu
    1090                1095                1100                
Ser Glu Asp Glu Phe Lys Ile Ser Asp Gly Ser Gln Asp Glu Phe Val
1105                1110                1115                1120
Val Ser Asp Glu Asn Pro Asp Glu Ser Glu Glu Asp Pro Pro Ser Asn
                1125                1130                1135    
Asp Asp Ser Asp Thr Asp Phe Cys Ser Arg Arg Leu Arg Arg His Pro
            1140                1145                1150        
Ser Arg Pro Met Arg Gln Ser Arg Arg Leu Arg Arg Lys Thr Pro Lys
        1155                1160                1165            
Lys Lys Tyr Ser Asp Asp Asp Glu Glu Glu Glu Ser Glu Glu Asn Ser
    1170                1175                1180                
Arg Asp Ser Glu Ser Asp Phe Ser Asp Asp Phe Ser Asp Asp Phe Val
1185                1190                1195                1200
Glu Thr Arg Arg Arg Arg Ser Arg Arg Asn Gln Lys Arg Gln Ile Asn
                1205                1210                1215    
Tyr Lys Glu Asp Ser Glu Ser Asp Gly Ser Gln Lys Ser Leu Arg Arg
            1220                1225                1230        
Gly Lys Glu Ile Arg Arg Val His Lys Arg Arg Leu Ser Ser Ser Glu
        1235                1240                1245            
Ser Glu Glu Ser Tyr Leu Ser Lys Asn Ser Glu Asp Asp Glu Leu Ala
    1250                1255                1260                
Lys Glu Ser Lys Arg Ser Val Arg Lys Arg Gly Arg Ser Thr Asp Glu
1265                1270                1275                1280
Tyr Ser Glu Ala Asp Glu Glu Glu Glu Glu Glu Glu Gly Lys Pro Ser
                1285                1290                1295    
Arg Lys Arg Leu His Arg Ile Glu Thr Asp Glu Glu Glu Ser Cys Asp
            1300                1305                1310        
Asn Ala His Gly Asp Ala Asn Gln Pro Ala Arg Asp Ser Gln Pro Arg
        1315                1320                1325            
Val Leu Pro Ser Glu Gln Glu Ser Thr Lys Lys Pro Tyr Arg Ile Glu
    1330                1335                1340                
Ser Asp Glu Glu Glu Asp Phe Glu Asn Val Gly Lys Val Gly Ser Pro
1345                1350                1355                1360
Leu Asp Tyr Ser Leu Val Asp Leu Pro Ser Thr Asn Gly Gln Ser Pro
                1365                1370                1375    
Gly Lys Ala Ile Glu Asn Leu Ile Gly Lys Pro Thr Glu Lys Ser Gln
            1380                1385                1390        
Thr Pro Lys Asp Asn Ser Thr Ala Ser Ala Ser Leu Ala Ser Asn Gly
        1395                1400                1405            
Thr Ser Gly Gly Gln Glu Ala Gly Ala Pro Glu Glu Glu Glu Asp Glu
    1410                1415                1420                
Leu Leu Arg Val Thr Asp Leu Val Asp Tyr Val Cys Asn Ser Glu Gln
1425                1430                1435                1440
Leu
    


<210> 9061
<211> 569
<212> PRT
<213> Homo sapiens

<400> 9061
Met His Thr Leu Thr Gly Phe Ser Leu Val Ser Leu Leu Ser Phe Gly
 1               5                  10                  15      
Tyr Leu Ser Trp Asp Trp Ala Lys Pro Ser Phe Val Ala Asp Gly Pro
            20                  25                  30          
Gly Glu Ala Gly Glu Gln Pro Ser Ala Ala Pro Pro Gln Pro Pro His
        35                  40                  45              
Ile Ile Phe Ile Leu Thr Asp Asp Gln Gly Tyr His Asp Val Gly Tyr
    50                  55                  60                  
His Gly Ser Asp Ile Glu Thr Pro Thr Leu Asp Arg Leu Ala Ala Lys
65                  70                  75                  80  
Gly Val Lys Leu Glu Asn Tyr Tyr Ile Gln Pro Ile Cys Thr Pro Ser
                85                  90                  95      
Arg Ser Gln Leu Leu Thr Gly Arg Tyr Gln Ile His Thr Gly Leu Gln
            100                 105                 110         
His Ser Ile Ile Arg Pro Gln Gln Pro Asn Cys Leu Pro Leu Asp Gln
        115                 120                 125             
Val Thr Leu Pro Gln Lys Leu Gln Glu Ala Gly Tyr Ser Thr His Met
    130                 135                 140                 
Val Gly Lys Trp His Leu Gly Phe Tyr Arg Lys Glu Cys Leu Pro Thr
145                 150                 155                 160 
Arg Arg Gly Phe Asp Thr Phe Leu Gly Ser Leu Thr Gly Asn Val Asp
                165                 170                 175     
Tyr Tyr Thr Tyr Asp Asn Cys Asp Gly Pro Gly Val Cys Gly Phe Asp
            180                 185                 190         
Leu His Glu Gly Glu Asn Val Ala Trp Gly Leu Ser Gly Gln Tyr Ser
        195                 200                 205             
Thr Met Leu Tyr Ala Gln Arg Ala Ser His Ile Leu Ala Ser His Ser
    210                 215                 220                 
Pro Gln Arg Pro Leu Phe Leu Tyr Val Ala Phe Gln Ala Val His Thr
225                 230                 235                 240 
Pro Leu Gln Ser Pro Arg Glu Tyr Leu Tyr Arg Tyr Arg Thr Met Gly
                245                 250                 255     
Asn Val Ala Arg Arg Lys Tyr Ala Ala Met Val Thr Cys Met Asp Glu
            260                 265                 270         
Ala Val Arg Asn Ile Thr Trp Ala Leu Lys Arg Tyr Gly Phe Tyr Asn
        275                 280                 285             
Asn Ser Val Ile Ile Phe Ser Ser Asp Asn Gly Gly Gln Thr Phe Ser
    290                 295                 300                 
Gly Gly Ser Asn Trp Pro Leu Arg Gly Arg Lys Gly Thr Tyr Trp Glu
305                 310                 315                 320 
Gly Gly Val Arg Gly Leu Gly Phe Val His Ser Pro Leu Leu Lys Arg
                325                 330                 335     
Lys Gln Arg Thr Ser Arg Ala Leu Met His Ile Thr Asp Trp Tyr Pro
            340                 345                 350         
Thr Leu Val Gly Leu Ala Gly Gly Thr Thr Ser Ala Ala Asp Gly Leu
        355                 360                 365             
Asp Gly Tyr Asp Val Trp Pro Ala Ile Ser Glu Gly Arg Ala Ser Pro
    370                 375                 380                 
Arg Thr Glu Ile Leu His Asn Ile Asp Pro Leu Tyr Asn His Ala Gln
385                 390                 395                 400 
His Gly Ser Leu Glu Gly Gly Phe Gly Ile Trp Asn Thr Ala Val Gln
                405                 410                 415     
Ala Ala Ile Arg Val Gly Glu Trp Lys Leu Leu Thr Gly Asp Pro Gly
            420                 425                 430         
Tyr Gly Asp Trp Ile Pro Pro Gln Thr Leu Ala Thr Phe Pro Gly Ser
        435                 440                 445             
Trp Trp Asn Leu Glu Arg Met Ala Ser Val Arg Gln Ala Val Trp Leu
    450                 455                 460                 
Phe Asn Ile Ser Ala Asp Pro Tyr Glu Arg Glu Asp Leu Ala Gly Gln
465                 470                 475                 480 
Arg Pro Asp Val Val Arg Thr Leu Leu Ala Arg Leu Ala Glu Tyr Asn
                485                 490                 495     
Arg Thr Ala Ile Pro Val Arg Tyr Pro Ala Glu Asn Pro Arg Ala His
            500                 505                 510         
Pro Asp Phe Asn Gly Gly Ala Trp Gly Pro Trp Ala Ser Asp Glu Glu
        515                 520                 525             
Glu Glu Glu Glu Glu Gly Arg Ala Arg Ser Phe Ser Arg Gly Arg Arg
    530                 535                 540                 
Lys Lys Lys Cys Lys Ile Cys Lys Leu Arg Ser Phe Phe Arg Lys Leu
545                 550                 555                 560 
Asn Thr Arg Leu Met Ser Gln Arg Ile
                565                 


<210> 9062
<211> 498
<212> PRT
<213> Homo sapiens

<400> 9062
Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu
 1               5                  10                  15      
Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn
            20                  25                  30          
Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val
        35                  40                  45              
Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val
    50                  55                  60                  
Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu
65                  70                  75                  80  
Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu
                85                  90                  95      
Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly
            100                 105                 110         
Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys
        115                 120                 125             
Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu
    130                 135                 140                 
Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg
145                 150                 155                 160 
Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala
                165                 170                 175     
Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu
            180                 185                 190         
Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu
        195                 200                 205             
Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser
    210                 215                 220                 
Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro
225                 230                 235                 240 
Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn
                245                 250                 255     
Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser
            260                 265                 270         
Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg
        275                 280                 285             
Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val
    290                 295                 300                 
Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys
305                 310                 315                 320 
Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val
                325                 330                 335     
Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro
            340                 345                 350         
His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe
        355                 360                 365             
Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly
    370                 375                 380                 
Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu
385                 390                 395                 400 
Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln
                405                 410                 415     
Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp
            420                 425                 430         
Ser Leu Asn Glu Pro Asp Arg Leu Pro Ser Ala Glu Ala Gln Leu Leu
        435                 440                 445             
Pro Pro Glu Leu Tyr Asn Pro Asn Phe Gln Glu Glu Glu Asp Glu Gly
    450                 455                 460                 
Gly Asp Glu Asn Ala Pro Gly Ser Pro Ser Phe Asp Gln Pro His Lys
465                 470                 475                 480 
Thr Cys Cys Pro Asp Leu Asn Ser Phe Ile Glu Ile Lys Val Glu Lys
                485                 490                 495     
Asp Glu
        


<210> 9063
<211> 538
<212> PRT
<213> Homo sapiens

<400> 9063
Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu
 1               5                  10                  15      
Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn
            20                  25                  30          
Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val
        35                  40                  45              
Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val
    50                  55                  60                  
Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu
65                  70                  75                  80  
Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu
                85                  90                  95      
Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly
            100                 105                 110         
Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys
        115                 120                 125             
Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu
    130                 135                 140                 
Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg
145                 150                 155                 160 
Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala
                165                 170                 175     
Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu
            180                 185                 190         
Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu
        195                 200                 205             
Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser
    210                 215                 220                 
Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro
225                 230                 235                 240 
Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn
                245                 250                 255     
Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser
            260                 265                 270         
Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg
        275                 280                 285             
Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val
    290                 295                 300                 
Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys
305                 310                 315                 320 
Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val
                325                 330                 335     
Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro
            340                 345                 350         
His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe
        355                 360                 365             
Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly
    370                 375                 380                 
Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu
385                 390                 395                 400 
Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln
                405                 410                 415     
Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp
            420                 425                 430         
Ser Leu Asn Glu Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg
        435                 440                 445             
Ala Gln Arg Leu Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys
    450                 455                 460                 
His Gly Thr Lys Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu
465                 470                 475                 480 
Pro Ser Ala Glu Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn
                485                 490                 495     
Phe Gln Glu Glu Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser
            500                 505                 510         
Pro Ser Phe Asp Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser
        515                 520                 525             
Phe Ile Glu Ile Lys Val Glu Lys Asp Glu
    530                 535             


<210> 9064
<211> 685
<212> PRT
<213> Homo sapiens

<400> 9064
Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu
 1               5                  10                  15      
Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu
            20                  25                  30          
Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg
        35                  40                  45              
Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His
    50                  55                  60                  
Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser
65                  70                  75                  80  
Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser
                85                  90                  95      
Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro
            100                 105                 110         
Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp
        115                 120                 125             
Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala
    130                 135                 140                 
Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln
145                 150                 155                 160 
Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser
                165                 170                 175     
Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn
            180                 185                 190         
Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys
        195                 200                 205             
Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser
    210                 215                 220                 
Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu
225                 230                 235                 240 
Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His
                245                 250                 255     
Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys
            260                 265                 270         
Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys
        275                 280                 285             
Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly
    290                 295                 300                 
Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp
305                 310                 315                 320 
Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly
                325                 330                 335     
Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro
            340                 345                 350         
Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp
        355                 360                 365             
Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala
    370                 375                 380                 
Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu
385                 390                 395                 400 
Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln
                405                 410                 415     
Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe
            420                 425                 430         
Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro
        435                 440                 445             
Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys
    450                 455                 460                 
Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser
465                 470                 475                 480 
Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr
                485                 490                 495     
Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe
            500                 505                 510         
Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro
        515                 520                 525             
Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu
    530                 535                 540                 
Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro
545                 550                 555                 560 
Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys
                565                 570                 575     
Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys
            580                 585                 590         
Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln
        595                 600                 605             
Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg
    610                 615                 620                 
Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu
625                 630                 635                 640 
Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser
                645                 650                 655     
Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile
            660                 665                 670         
Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val
        675                 680                 685 


<210> 9065
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 9065
Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala
 1               5                  10                  15      
Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly
            20                  25                  30          
Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala
        35                  40                  45              
Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu
    50                  55                  60                  
Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr
65                  70                  75                  80  
Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe
                85                  90                  95      
Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala
            100                 105                 110         
Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys
        115                 120                 125             
Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn
    130                 135                 140                 
Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp
145                 150                 155                 160 
Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Val Gly Leu Met
                165                 170                 175     
Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu
            180                 185                 190         
Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln
        195                 200                 205             
Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala
    210                 215                 220                 
Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln
225                 230                 235                 240 
Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val
                245                 250                 255     
Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr
            260                 265                 270         
Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr
        275                 280                 285             
Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe
    290                 295                 300                 
Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr
305                 310                 315                 320 
Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp
                325                 330                 335     
Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala
            340                 345                 350         
Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro
        355                 360                 365             
Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys
    370                 375                 380                 
Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln
385                 390                 395                 400 
Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu
                405                 410                 415     
Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr
            420                 425                 430         
Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Asn Thr Ser Asp Asn
        435                 440                 445             
Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala
    450                 455                 460                 
His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu
465                 470                 475                 480 
Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu
                485                 490                 495     
Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro
            500                 505                 510         
Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr
        515                 520                 525             
Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln
    530                 535                 540                 
Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro
545                 550                 555                 560 
Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His
                565                 570                 575     
Val Pro Cys Ser Thr Ser Arg Thr Arg Gly Ser Thr Asp Thr Ile Leu
            580                 585                 590         
Ile Gly Asn Asn His Ile Thr Gly Asn Gly Ser Asn Gly Asn Val Pro
        595                 600                 605             
Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu
    610                 615                 620                 
Thr Ser Ser Ala Lys Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr
625                 630                 635                 640 
Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly
                645                 650                 655     
Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala
            660                 665                 670         
Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn
        675                 680                 685             
Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala
    690                 695                 700                 
Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro
705                 710                 715                 720 
Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu
                725                 730                 735     
Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His
            740                 745                 750         
Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys
        755                 760                 765             
Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu
    770                 775                 780                 
Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val
785                 790                 795                 800 
Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala
                805                 810                 815     
Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser
            820                 825                 830         
Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His
        835                 840                 845             
Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser
    850                 855                 860                 
Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln
865                 870                 875                 880 
Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val
                885                 890                 895     
Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser
            900                 905                 910         
Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr
        915                 920                 925             
Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr
    930                 935                 940                 
Leu Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys
945                 950                 955                 960 
Thr Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala
                965                 970                 975     
Leu Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala
            980                 985                 990         
Asn Asn Glu His Met Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala
        995                 1000                1005            
Asp Glu Asn Trp Asp Pro Thr Gly Thr Lys Lys Ile Trp His Cys Glu
    1010                1015                1020                
Ser Asn Arg Ser His Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala
1025                1030                1035                1040
Ser Ser Phe Gln Glu Ser Leu Arg Glu Glu Asn Glu Lys Arg Ser His
                1045                1050                1055    
His Lys Asp His Ser Asp Ser Glu Ser Thr Ser Ser Asp Asn Ser Gly
            1060                1065                1070        
Arg Arg Arg Lys Gly Pro Phe Lys Thr Ile Lys Phe Gly Thr Asn Ile
        1075                1080                1085            
Asp Leu Ser Asp Asp Lys Lys Trp Lys Leu Gln Leu His Glu Leu Thr
    1090                1095                1100                
Lys Leu Pro Ala Phe Val Arg Val Val Ser Ala Gly Asn Leu Leu Ser
1105                1110                1115                1120
His Val Gly His Thr Ile Leu Gly Met Asn Thr Val Gln Leu Tyr Met
                1125                1130                1135    
Lys Val Pro Gly Ser Arg Thr Pro Gly His Gln Glu Asn Asn Asn Phe
            1140                1145                1150        
Cys Ser Val Asn Ile Asn Ile Gly Pro Gly Asp Cys Glu Trp Phe Val
        1155                1160                1165            
Val Pro Glu Gly Tyr Trp Gly Val Leu Asn Asp Phe Cys Glu Lys Asn
    1170                1175                1180                
Asn Leu Asn Phe Leu Met Gly Ser Trp Trp Pro Asn Leu Glu Asp Leu
1185                1190                1195                1200
Tyr Glu Ala Asn Val Pro Val Tyr Arg Phe Ile Gln Arg Pro Gly Asp
                1205                1210                1215    
Leu Val Trp Ile Asn Ala Gly Thr Val His Trp Val Gln Ala Ile Gly
            1220                1225                1230        
Trp Cys Asn Asn Ile Ala Trp Asn Val Gly Pro Leu Thr Ala Cys Gln
        1235                1240                1245            
Tyr Lys Leu Ala Val Glu Arg Tyr Glu Trp Asn Lys Leu Gln Ser Val
    1250                1255                1260                
Lys Ser Ile Val Pro Met Val His Leu Ser Trp Asn Met Ala Arg Asn
1265                1270                1275                1280
Ile Lys Val Ser Asp Pro Lys Leu Phe Glu Met Ile Lys Tyr Cys Leu
                1285                1290                1295    
Leu Arg Thr Leu Lys Gln Cys Gln Thr Leu Arg Glu Ala Leu Ile Ala
            1300                1305                1310        
Ala Gly Lys Glu Ile Ile Trp His Gly Arg Thr Lys Glu Glu Pro Ala
        1315                1320                1325            
His Tyr Cys Ser Ile Cys Glu Val Glu Val Phe Asp Leu Leu Phe Val
    1330                1335                1340                
Thr Asn Glu Ser Asn Ser Arg Lys Thr Tyr Ile Val His Cys Gln Asp
1345                1350                1355                1360
Cys Ala Arg Lys Thr Ser Gly Asn Leu Glu Asn Phe Val Val Leu Glu
                1365                1370                1375    
Gln Tyr Lys Met Glu Asp Leu Met Gln Val Tyr Asp Gln Phe Thr Leu
            1380                1385                1390        
Ala Pro Pro Leu Pro Ser Ala Ser Ser
        1395                1400    


<210> 9066
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 9066
Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr Ser Arg
 1               5                  10                  15      
Gln Gly Ala Met Asn Thr Ala Gln Gln Ala Cys Lys Pro His His Pro
            20                  25                  30          
Asn Thr Glu Pro Val Leu Gly Leu Ser Gln Thr Pro Ile Ser Gln Gln
        35                  40                  45              
Ser Leu Pro Leu His Met Ile Pro Ser Ser Gln Val Asp Asp Leu Ser
    50                  55                  60                  
Ser Pro Ala Lys Arg Lys Arg Thr Ser Ser Pro Thr Lys Asn Thr Ser
65                  70                  75                  80  
Asp Asn Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln
                85                  90                  95      
Gln Ala His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu
            100                 105                 110         
Gln Leu Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met
        115                 120                 125             
Leu Glu Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met
    130                 135                 140                 
Arg Pro Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly
145                 150                 155                 160 
Pro Thr Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln
                165                 170                 175     
Pro Gln Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val
            180                 185                 190         
Arg Pro Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala
        195                 200                 205             
Gly His Val Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr
    210                 215                 220                 
Ile Leu Ile Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn
225                 230                 235                 240 
Val Pro Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr
                245                 250                 255     
Asn Leu Thr Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn
            260                 265                 270         
Ser Thr Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro
        275                 280                 285             
Asn Gly Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln
    290                 295                 300                 
Ala Ala Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro
305                 310                 315                 320 
Ser Asn Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His
                325                 330                 335     
Thr Ala Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser
            340                 345                 350         
Lys Pro Ser Gly Asn Ile Leu Lys Val Pro Glu Thr Ser Arg His Thr
        355                 360                 365             
Gly Glu Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His
    370                 375                 380                 
Val His Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp
385                 390                 395                 400 
Ser Lys Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala
                405                 410                 415     
Leu Leu Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp
            420                 425                 430         
Lys Val Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser
        435                 440                 445             
Val Ala Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro
    450                 455                 460                 
Lys Ser Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser
465                 470                 475                 480 
Pro His Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser
                485                 490                 495     
Gln Ser Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser
            500                 505                 510         
Pro Gln Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala
        515                 520                 525             
Glu Val Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn
    530                 535                 540                 
Ser Ser Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser
545                 550                 555                 560 
Pro Tyr Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser
                565                 570                 575     
Ile Tyr Leu Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln
            580                 585                 590         
Phe Cys Thr Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala
        595                 600                 605             
Gly Ala Leu Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val
    610                 615                 620                 
Glu Ala Asn Asn Glu His Met Val Glu Val Arg Thr Gln Leu Leu Gln
625                 630                 635                 640 
Pro Ala Asp Glu Asn Trp Asp Pro Thr Gly Thr Lys Lys Ile Trp His
                645                 650                 655     
Cys Glu Ser Asn Arg Ser His Thr Thr Ile Ala Lys Tyr Ala Gln Tyr
            660                 665                 670         
Gln Ala Ser Ser Phe Gln Glu Ser Leu Arg Glu Glu Asn Glu Lys Arg
        675                 680                 685             
Ser His His Lys Asp His Ser Asp Ser Glu Ser Thr Ser Ser Asp Asn
    690                 695                 700                 
Ser Gly Arg Arg Arg Lys Gly Pro Phe Lys Thr Ile Lys Phe Gly Thr
705                 710                 715                 720 
Asn Ile Asp Leu Ser Asp Asp Lys Lys Trp Lys Leu Gln Leu His Glu
                725                 730                 735     
Leu Thr Lys Leu Pro Ala Phe Val Arg Val Val Ser Ala Gly Asn Leu
            740                 745                 750         
Leu Ser His Val Gly His Thr Ile Leu Gly Met Asn Thr Val Gln Leu
        755                 760                 765             
Tyr Met Lys Val Pro Gly Ser Arg Thr Pro Gly His Gln Glu Asn Asn
    770                 775                 780                 
Asn Phe Cys Ser Val Asn Ile Asn Ile Gly Pro Gly Asp Cys Glu Trp
785                 790                 795                 800 
Phe Val Val Pro Glu Gly Tyr Trp Gly Val Leu Asn Asp Phe Cys Glu
                805                 810                 815     
Lys Asn Asn Leu Asn Phe Leu Met Gly Ser Trp Trp Pro Asn Leu Glu
            820                 825                 830         
Asp Leu Tyr Glu Ala Asn Val Pro Val Tyr Arg Phe Ile Gln Arg Pro
        835                 840                 845             
Gly Asp Leu Val Trp Ile Asn Ala Gly Thr Val His Trp Val Gln Ala
    850                 855                 860                 
Ile Gly Trp Cys Asn Asn Ile Ala Trp Asn Val Gly Pro Leu Thr Ala
865                 870                 875                 880 
Cys Gln Tyr Lys Leu Ala Val Glu Arg Tyr Glu Trp Asn Lys Leu Gln
                885                 890                 895     
Ser Val Lys Ser Ile Val Pro Met Val His Leu Ser Trp Asn Met Ala
            900                 905                 910         
Arg Asn Ile Lys Val Ser Asp Pro Lys Leu Phe Glu Met Ile Lys Tyr
        915                 920                 925             
Cys Leu Leu Arg Thr Leu Lys Gln Cys Gln Thr Leu Arg Glu Ala Leu
    930                 935                 940                 
Ile Ala Ala Gly Lys Glu Ile Ile Trp His Gly Arg Thr Lys Glu Glu
945                 950                 955                 960 
Pro Ala His Tyr Cys Ser Ile Cys Glu Val Glu Val Phe Asp Leu Leu
                965                 970                 975     
Phe Val Thr Asn Glu Ser Asn Ser Arg Lys Thr Tyr Ile Val His Cys
            980                 985                 990         
Gln Asp Cys Ala Arg Lys Thr Ser Gly Asn Leu Glu Asn Phe Val Val
        995                 1000                1005            
Leu Glu Gln Tyr Lys Met Glu Asp Leu Met Gln Val Cys Asp Gln Phe
    1010                1015                1020                
Thr Leu Ala Pro Pro Leu Pro Ser Ala Ser Ser
1025                1030                1035


<210> 9067
<211> 496
<212> PRT
<213> Homo sapiens

<400> 9067
Met Gly Arg Arg Ala Leu Leu Leu Leu Leu Leu Ser Phe Leu Ala Pro
 1               5                  10                  15      
Trp Ala Thr Ile Ala Leu Arg Pro Ala Leu Arg Ala Leu Gly Ser Leu
            20                  25                  30          
His Leu Pro Thr Asn Pro Thr Ser Leu Pro Ala Val Ala Lys Asn Tyr
        35                  40                  45              
Ser Val Leu Tyr Phe Gln Gln Lys Val Asp His Phe Gly Phe Asn Thr
    50                  55                  60                  
Val Lys Thr Phe Asn Gln Arg Tyr Leu Val Ala Asp Lys Tyr Trp Lys
65                  70                  75                  80  
Lys Asn Gly Gly Ser Ile Leu Phe Tyr Thr Gly Asn Glu Gly Asp Ile
                85                  90                  95      
Ile Trp Phe Cys Asn Asn Thr Gly Phe Met Trp Asp Val Ala Glu Glu
            100                 105                 110         
Leu Lys Ala Met Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Glu Ser
        115                 120                 125             
Leu Pro Phe Gly Asp Asn Ser Phe Lys Asp Ser Arg His Leu Asn Phe
    130                 135                 140                 
Leu Thr Ser Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Ile Lys His
145                 150                 155                 160 
Leu Lys Arg Thr Ile Pro Gly Ala Glu Asn Gln Pro Val Ile Ala Ile
                165                 170                 175     
Gly Gly Ser Tyr Gly Gly Met Leu Ala Ala Trp Phe Arg Met Lys Tyr
            180                 185                 190         
Pro His Met Val Val Gly Ala Leu Ala Ala Ser Ala Pro Ile Trp Gln
        195                 200                 205             
Phe Glu Asp Leu Val Pro Cys Gly Val Phe Met Lys Ile Val Thr Thr
    210                 215                 220                 
Asp Phe Arg Lys Ser Gly Pro His Cys Ser Glu Ser Ile His Arg Ser
225                 230                 235                 240 
Trp Asp Ala Ile Asn Arg Leu Ser Asn Thr Gly Ser Gly Leu Gln Trp
                245                 250                 255     
Leu Thr Gly Ala Leu His Leu Cys Ser Pro Leu Thr Ser Gln Asp Ile
            260                 265                 270         
Gln His Leu Lys Asp Trp Ile Ser Glu Thr Trp Val Asn Leu Ala Met
        275                 280                 285             
Val Asp Tyr Pro Tyr Ala Ser Asn Phe Leu Gln Pro Leu Pro Ala Trp
    290                 295                 300                 
Pro Ile Lys Val Val Cys Gln Tyr Leu Lys Asn Pro Asn Val Ser Asp
305                 310                 315                 320 
Ser Leu Leu Leu Gln Asn Ile Phe Gln Ala Leu Asn Val Tyr Tyr Asn
                325                 330                 335     
Tyr Ser Gly Gln Val Lys Cys Leu Asn Ile Ser Glu Thr Ala Thr Ser
            340                 345                 350         
Ser Leu Gly Thr Leu Gly Trp Ser Tyr Gln Ala Cys Thr Glu Val Val
        355                 360                 365             
Met Pro Phe Cys Thr Asn Gly Val Asp Asp Met Phe Glu Pro His Ser
    370                 375                 380                 
Trp Asn Leu Lys Glu Leu Ser Asp Asp Cys Phe Gln Gln Trp Gly Val
385                 390                 395                 400 
Arg Pro Arg Pro Ser Trp Ile Thr Thr Met Tyr Gly Gly Lys Asn Ile
                405                 410                 415     
Ser Ser His Thr Asn Ile Val Phe Ser Asn Gly Glu Leu Asp Pro Trp
            420                 425                 430         
Ser Gly Gly Gly Val Thr Lys Asp Ile Thr Asp Thr Leu Val Ala Val
        435                 440                 445             
Thr Ile Ser Glu Gly Ala His His Leu Asp Leu Arg Thr Lys Asn Ala
    450                 455                 460                 
Leu Asp Pro Met Ser Val Leu Leu Ala Arg Ser Leu Glu Val Arg His
465                 470                 475                 480 
Met Lys Asn Trp Ile Arg Asp Phe Tyr Asp Ser Ala Gly Lys Gln His
                485                 490                 495     


<210> 9068
<211> 3396
<212> PRT
<213> Homo sapiens

<400> 9068
Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile
 1               5                  10                  15      
Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val
            20                  25                  30          
Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr
        35                  40                  45              
Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile
    50                  55                  60                  
Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu
65                  70                  75                  80  
Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp
                85                  90                  95      
Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp
            100                 105                 110         
Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr
        115                 120                 125             
Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser
    130                 135                 140                 
Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg
145                 150                 155                 160 
Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly
                165                 170                 175     
Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly
            180                 185                 190         
Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr
        195                 200                 205             
Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys
    210                 215                 220                 
Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp
225                 230                 235                 240 
Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr
                245                 250                 255     
Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn
            260                 265                 270         
Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg
        275                 280                 285             
Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val
    290                 295                 300                 
Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu
305                 310                 315                 320 
Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro
                325                 330                 335     
Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr
            340                 345                 350         
Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser
        355                 360                 365             
Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu
    370                 375                 380                 
Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn
385                 390                 395                 400 
Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr
                405                 410                 415     
Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys
            420                 425                 430         
Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly
        435                 440                 445             
Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr
    450                 455                 460                 
Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp
465                 470                 475                 480 
Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly
                485                 490                 495     
Pro Leu Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu
            500                 505                 510         
Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu
        515                 520                 525             
Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr
    530                 535                 540                 
Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg
545                 550                 555                 560 
Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile
                565                 570                 575     
Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr
            580                 585                 590         
His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro
        595                 600                 605             
Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu
    610                 615                 620                 
Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu
625                 630                 635                 640 
Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe
                645                 650                 655     
Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile
            660                 665                 670         
Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu
        675                 680                 685             
Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln
    690                 695                 700                 
Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val
705                 710                 715                 720 
Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val
                725                 730                 735     
Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu
            740                 745                 750         
Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu
        755                 760                 765             
Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr
    770                 775                 780                 
Thr Val Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val
785                 790                 795                 800 
Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu
                805                 810                 815     
Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr
            820                 825                 830         
Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu
        835                 840                 845             
Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln
    850                 855                 860                 
Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr
865                 870                 875                 880 
Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr
                885                 890                 895     
Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr
            900                 905                 910         
Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val
        915                 920                 925             
Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala
    930                 935                 940                 
His Thr Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr
945                 950                 955                 960 
Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser
                965                 970                 975     
Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser
            980                 985                 990         
Glu Asp Glu Val Leu Gly Glu Pro Ser Gln Asp Ile Leu Val Ile Asp
        995                 1000                1005            
Gln Thr Arg Leu Glu Ala Thr Ile Ser Pro Glu Thr Met Arg Thr Thr
    1010                1015                1020                
Lys Ile Thr Glu Gly Thr Thr Gln Glu Glu Phe Pro Trp Lys Glu Gln
1025                1030                1035                1040
Thr Ala Glu Lys Pro Val Pro Ala Leu Ser Ser Thr Ala Trp Thr Pro
                1045                1050                1055    
Lys Glu Ala Val Thr Pro Leu Asp Glu Gln Glu Gly Asp Gly Ser Ala
            1060                1065                1070        
Tyr Thr Val Ser Glu Asp Glu Leu Leu Thr Gly Ser Glu Arg Val Pro
        1075                1080                1085            
Val Leu Glu Thr Thr Pro Val Gly Lys Ile Asp His Ser Val Ser Tyr
    1090                1095                1100                
Pro Pro Gly Ala Val Thr Glu His Lys Val Lys Thr Asp Glu Val Val
1105                1110                1115                1120
Thr Leu Thr Pro Arg Ile Gly Pro Lys Val Ser Leu Ser Pro Gly Pro
                1125                1130                1135    
Glu Gln Lys Tyr Glu Thr Glu Gly Ser Ser Thr Thr Gly Phe Thr Ser
            1140                1145                1150        
Ser Leu Ser Pro Phe Ser Thr His Ile Thr Gln Leu Met Glu Glu Thr
        1155                1160                1165            
Thr Thr Glu Lys Thr Ser Leu Glu Asp Ile Asp Leu Gly Ser Gly Leu
    1170                1175                1180                
Phe Glu Lys Pro Lys Ala Thr Glu Leu Ile Glu Phe Ser Thr Ile Lys
1185                1190                1195                1200
Val Thr Val Pro Ser Asp Ile Thr Thr Ala Phe Ser Ser Val Asp Arg
                1205                1210                1215    
Leu His Thr Thr Ser Ala Phe Lys Pro Ser Ser Ala Ile Thr Lys Lys
            1220                1225                1230        
Pro Pro Leu Ile Asp Arg Glu Pro Gly Glu Glu Thr Thr Ser Asp Met
        1235                1240                1245            
Val Ile Ile Gly Glu Ser Thr Ser His Val Pro Pro Thr Thr Leu Glu
    1250                1255                1260                
Asp Ile Val Ala Lys Glu Thr Glu Thr Asp Ile Asp Arg Glu Tyr Phe
1265                1270                1275                1280
Thr Thr Ser Ser Pro Pro Ala Thr Gln Pro Thr Arg Pro Pro Thr Val
                1285                1290                1295    
Glu Asp Lys Glu Ala Phe Gly Pro Gln Ala Leu Ser Thr Pro Gln Pro
            1300                1305                1310        
Pro Ala Ser Thr Lys Phe His Pro Asp Ile Asn Val Tyr Ile Ile Glu
        1315                1320                1325            
Val Arg Glu Asn Lys Thr Gly Arg Met Ser Asp Leu Ser Val Ile Gly
    1330                1335                1340                
His Pro Ile Asp Ser Glu Ser Lys Glu Asp Glu Pro Cys Ser Glu Glu
1345                1350                1355                1360
Thr Asp Pro Val His Asp Leu Met Ala Glu Ile Leu Pro Glu Phe Pro
                1365                1370                1375    
Asp Ile Ile Glu Ile Asp Leu Tyr His Ser Glu Glu Asn Glu Glu Glu
            1380                1385                1390        
Glu Glu Glu Cys Ala Asn Ala Thr Asp Val Thr Thr Thr Pro Ser Val
        1395                1400                1405            
Gln Tyr Ile Asn Gly Lys His Leu Val Thr Thr Val Pro Lys Asp Pro
    1410                1415                1420                
Glu Ala Ala Glu Ala Arg Arg Gly Gln Phe Glu Ser Val Ala Pro Ser
1425                1430                1435                1440
Gln Asn Phe Ser Asp Ser Ser Glu Ser Asp Thr His Pro Phe Val Ile
                1445                1450                1455    
Ala Lys Thr Glu Leu Ser Thr Ala Val Gln Pro Asn Glu Ser Thr Glu
            1460                1465                1470        
Thr Thr Glu Ser Leu Glu Val Thr Trp Lys Pro Glu Thr Tyr Pro Glu
        1475                1480                1485            
Thr Ser Glu His Phe Ser Gly Gly Glu Pro Asp Val Phe Pro Thr Val
    1490                1495                1500                
Pro Phe His Glu Glu Phe Glu Ser Gly Thr Ala Lys Lys Gly Ala Glu
1505                1510                1515                1520
Ser Val Thr Glu Arg Asp Thr Glu Val Gly His Gln Ala His Glu His
                1525                1530                1535    
Thr Glu Pro Val Ser Leu Phe Pro Glu Glu Ser Ser Gly Glu Ile Ala
            1540                1545                1550        
Ile Asp Gln Glu Ser Gln Lys Ile Ala Phe Ala Arg Ala Thr Glu Val
        1555                1560                1565            
Thr Phe Gly Glu Glu Val Glu Lys Ser Thr Ser Val Thr Tyr Thr Pro
    1570                1575                1580                
Thr Ile Val Pro Ser Ser Ala Ser Ala Tyr Val Ser Glu Glu Glu Ala
1585                1590                1595                1600
Val Thr Leu Ile Gly Asn Pro Trp Pro Asp Asp Leu Leu Ser Thr Lys
                1605                1610                1615    
Glu Ser Trp Val Glu Ala Thr Pro Arg Gln Val Val Glu Leu Ser Gly
            1620                1625                1630        
Ser Ser Ser Ile Pro Ile Thr Glu Gly Ser Gly Glu Ala Glu Glu Asp
        1635                1640                1645            
Glu Asp Thr Met Phe Thr Met Val Thr Asp Leu Ser Gln Arg Asn Thr
    1650                1655                1660                
Thr Asp Thr Leu Ile Thr Leu Asp Thr Ser Arg Ile Ile Thr Glu Ser
1665                1670                1675                1680
Phe Phe Glu Val Pro Ala Thr Thr Ile Tyr Pro Val Ser Glu Gln Pro
                1685                1690                1695    
Ser Ala Lys Val Val Pro Thr Lys Phe Val Ser Glu Thr Asp Thr Ser
            1700                1705                1710        
Glu Trp Ile Ser Ser Thr Thr Val Glu Glu Lys Lys Arg Lys Glu Glu
        1715                1720                1725            
Glu Gly Thr Thr Gly Thr Ala Ser Thr Phe Glu Val Tyr Ser Ser Thr
    1730                1735                1740                
Gln Arg Ser Asp Gln Leu Ile Leu Pro Phe Glu Leu Glu Ser Pro Asn
1745                1750                1755                1760
Val Ala Thr Ser Ser Asp Ser Gly Thr Arg Lys Ser Phe Met Ser Leu
                1765                1770                1775    
Thr Thr Pro Thr Gln Ser Glu Arg Glu Met Thr Asp Ser Thr Pro Val
            1780                1785                1790        
Phe Thr Glu Thr Asn Thr Leu Glu Asn Leu Gly Ala Gln Thr Thr Glu
        1795                1800                1805            
His Ser Ser Ile His Gln Pro Gly Val Gln Glu Gly Leu Thr Thr Leu
    1810                1815                1820                
Pro Arg Ser Pro Ala Ser Val Phe Met Glu Gln Gly Ser Gly Glu Ala
1825                1830                1835                1840
Ala Ala Asp Pro Glu Thr Thr Thr Val Ser Ser Phe Ser Leu Asn Val
                1845                1850                1855    
Glu Tyr Ala Ile Gln Ala Glu Lys Glu Val Ala Gly Thr Leu Ser Pro
            1860                1865                1870        
His Val Glu Thr Thr Phe Ser Thr Glu Pro Thr Gly Leu Val Leu Ser
        1875                1880                1885            
Thr Val Met Asp Arg Val Val Ala Glu Asn Ile Thr Gln Thr Ser Arg
    1890                1895                1900                
Glu Ile Val Ile Ser Glu Arg Leu Gly Glu Pro Asn Tyr Gly Ala Glu
1905                1910                1915                1920
Ile Arg Gly Phe Ser Thr Gly Phe Pro Leu Glu Glu Asp Phe Ser Gly
                1925                1930                1935    
Asp Phe Arg Glu Tyr Ser Thr Val Ser His Pro Ile Ala Lys Glu Glu
            1940                1945                1950        
Thr Val Met Met Glu Gly Ser Gly Asp Ala Ala Phe Arg Asp Thr Gln
        1955                1960                1965            
Thr Ser Pro Ser Thr Val Pro Thr Ser Val His Ile Ser His Ile Ser
    1970                1975                1980                
Asp Ser Glu Gly Pro Ser Ser Thr Met Val Ser Thr Ser Ala Phe Pro
1985                1990                1995                2000
Trp Glu Glu Phe Thr Ser Ser Ala Glu Gly Ser Gly Glu Gln Leu Val
                2005                2010                2015    
Thr Val Ser Ser Ser Val Val Pro Val Leu Pro Ser Ala Val Gln Lys
            2020                2025                2030        
Phe Ser Gly Thr Ala Ser Ser Ile Ile Asp Glu Gly Leu Gly Glu Val
        2035                2040                2045            
Gly Thr Val Asn Glu Ile Asp Arg Arg Ser Thr Ile Leu Pro Thr Ala
    2050                2055                2060                
Glu Val Glu Gly Thr Lys Ala Pro Val Glu Lys Glu Glu Val Lys Val
2065                2070                2075                2080
Ser Gly Thr Val Ser Thr Asn Phe Pro Gln Thr Ile Glu Pro Ala Lys
                2085                2090                2095    
Leu Trp Ser Arg Gln Glu Val Asn Pro Val Arg Gln Glu Ile Glu Ser
            2100                2105                2110        
Glu Thr Thr Ser Glu Glu Gln Ile Gln Glu Glu Lys Ser Phe Glu Ser
        2115                2120                2125            
Pro Gln Asn Ser Pro Ala Thr Glu Gln Thr Ile Phe Asp Ser Gln Thr
    2130                2135                2140                
Phe Thr Glu Thr Glu Leu Lys Thr Thr Asp Tyr Ser Val Leu Thr Thr
2145                2150                2155                2160
Lys Lys Thr Tyr Ser Asp Asp Lys Glu Met Lys Glu Glu Asp Thr Ser
                2165                2170                2175    
Leu Val Asn Met Ser Thr Pro Asp Pro Asp Ala Asn Gly Leu Glu Ser
            2180                2185                2190        
Tyr Thr Thr Leu Pro Glu Ala Thr Glu Lys Ser His Phe Phe Leu Ala
        2195                2200                2205            
Thr Ala Leu Val Thr Glu Ser Ile Pro Ala Glu His Val Val Thr Asp
    2210                2215                2220                
Ser Pro Ile Lys Lys Glu Glu Ser Thr Lys His Phe Pro Lys Gly Met
2225                2230                2235                2240
Arg Pro Thr Ile Gln Glu Ser Asp Thr Glu Leu Leu Phe Ser Gly Leu
                2245                2250                2255    
Gly Ser Gly Glu Glu Val Leu Pro Thr Leu Pro Thr Glu Ser Val Asn
            2260                2265                2270        
Phe Thr Glu Val Glu Gln Ile Asn Asn Thr Leu Tyr Pro His Thr Ser
        2275                2280                2285            
Gln Val Glu Ser Thr Ser Ser Asp Lys Ile Glu Asp Phe Asn Arg Met
    2290                2295                2300                
Glu Asn Val Ala Lys Glu Val Gly Pro Leu Val Ser Gln Thr Asp Ile
2305                2310                2315                2320
Phe Glu Gly Ser Gly Ser Val Thr Ser Thr Thr Leu Ile Glu Ile Leu
                2325                2330                2335    
Ser Asp Thr Gly Ala Glu Gly Pro Thr Val Ala Pro Leu Pro Phe Ser
            2340                2345                2350        
Thr Asp Ile Gly His Pro Gln Asn Gln Thr Val Arg Trp Ala Glu Glu
        2355                2360                2365            
Ile Gln Thr Ser Arg Pro Gln Thr Ile Thr Glu Gln Asp Ser Asn Lys
    2370                2375                2380                
Asn Ser Ser Thr Ala Glu Ile Asn Glu Thr Thr Thr Ser Ser Thr Asp
2385                2390                2395                2400
Phe Leu Ala Arg Ala Tyr Gly Phe Glu Met Ala Lys Glu Phe Val Thr
                2405                2410                2415    
Ser Ala Pro Lys Pro Ser Asp Leu Tyr Tyr Glu Pro Ser Gly Glu Gly
            2420                2425                2430        
Ser Gly Glu Val Asp Ile Val Asp Ser Phe His Thr Ser Ala Thr Thr
        2435                2440                2445            
Gln Ala Thr Arg Gln Glu Ser Ser Thr Thr Phe Val Ser Asp Gly Ser
    2450                2455                2460                
Leu Glu Lys His Pro Glu Val Pro Ser Ala Lys Ala Val Thr Ala Asp
2465                2470                2475                2480
Gly Phe Pro Thr Val Ser Val Met Leu Pro Leu His Ser Glu Gln Asn
                2485                2490                2495    
Lys Ser Ser Pro Asp Pro Thr Ser Thr Leu Ser Asn Thr Val Ser Tyr
            2500                2505                2510        
Glu Arg Ser Thr Asp Gly Ser Phe Gln Asp Arg Phe Arg Glu Phe Glu
        2515                2520                2525            
Asp Ser Thr Leu Lys Pro Asn Arg Lys Lys Pro Thr Glu Asn Ile Ile
    2530                2535                2540                
Ile Asp Leu Asp Lys Glu Asp Lys Asp Leu Ile Leu Thr Ile Thr Glu
2545                2550                2555                2560
Ser Thr Ile Leu Glu Ile Leu Pro Glu Leu Thr Ser Asp Lys Asn Thr
                2565                2570                2575    
Ile Ile Asp Ile Asp His Thr Lys Pro Val Tyr Glu Asp Ile Leu Gly
            2580                2585                2590        
Met Gln Thr Asp Ile Asp Thr Glu Val Pro Ser Glu Pro His Asp Ser
        2595                2600                2605            
Asn Asp Glu Ser Asn Asp Asp Ser Thr Gln Val Gln Glu Ile Tyr Glu
    2610                2615                2620                
Ala Ala Val Asn Leu Ser Leu Thr Glu Glu Thr Phe Glu Gly Ser Ala
2625                2630                2635                2640
Asp Val Leu Ala Ser Tyr Thr Gln Ala Thr His Asp Glu Ser Met Thr
                2645                2650                2655    
Tyr Glu Asp Arg Ser Gln Leu Asp His Met Gly Phe His Phe Thr Thr
            2660                2665                2670        
Gly Ile Pro Ala Pro Ser Thr Glu Thr Glu Leu Asp Val Leu Leu Pro
        2675                2680                2685            
Thr Ala Thr Ser Leu Pro Ile Pro Arg Lys Ser Ala Thr Val Ile Pro
    2690                2695                2700                
Glu Ile Glu Gly Ile Lys Ala Glu Ala Lys Ala Leu Asp Asp Met Phe
2705                2710                2715                2720
Glu Ser Ser Thr Leu Ser Asp Gly Gln Ala Ile Ala Asp Gln Ser Glu
                2725                2730                2735    
Ile Ile Pro Thr Leu Gly Gln Phe Glu Arg Thr Gln Glu Glu Tyr Glu
            2740                2745                2750        
Asp Lys Lys His Ala Gly Pro Ser Phe Gln Pro Glu Phe Ser Ser Gly
        2755                2760                2765            
Ala Glu Glu Ala Leu Val Asp His Thr Pro Tyr Leu Ser Ile Ala Thr
    2770                2775                2780                
Thr His Leu Met Asp Gln Ser Val Thr Glu Val Pro Asp Val Met Glu
2785                2790                2795                2800
Gly Ser Asn Pro Pro Tyr Tyr Thr Asp Thr Thr Leu Ala Val Ser Thr
                2805                2810                2815    
Phe Ala Lys Leu Ser Ser Gln Thr Pro Ser Ser Pro Leu Thr Ile Tyr
            2820                2825                2830        
Ser Gly Ser Glu Ala Ser Gly His Thr Glu Ile Pro Gln Pro Ser Ala
        2835                2840                2845            
Leu Pro Gly Ile Asp Val Gly Ser Ser Val Met Ser Pro Gln Asp Ser
    2850                2855                2860                
Phe Lys Glu Ile His Val Asn Ile Glu Ala Thr Phe Lys Pro Ser Ser
2865                2870                2875                2880
Glu Glu Tyr Leu His Ile Thr Glu Pro Pro Ser Leu Ser Pro Asp Thr
                2885                2890                2895    
Lys Leu Glu Pro Ser Glu Asp Asp Gly Lys Pro Glu Leu Leu Glu Glu
            2900                2905                2910        
Met Glu Ala Ser Pro Thr Glu Leu Ile Ala Val Glu Gly Thr Glu Ile
        2915                2920                2925            
Leu Gln Asp Phe Gln Asn Lys Thr Asp Gly Gln Val Ser Gly Glu Ala
    2930                2935                2940                
Ile Lys Met Phe Pro Thr Ile Lys Thr Pro Glu Ala Gly Thr Val Ile
2945                2950                2955                2960
Thr Thr Ala Asp Glu Ile Glu Leu Glu Gly Ala Thr Gln Trp Pro His
                2965                2970                2975    
Ser Thr Ser Ala Ser Ala Thr Tyr Gly Val Glu Ala Gly Val Val Pro
            2980                2985                2990        
Trp Leu Ser Pro Gln Thr Ser Glu Arg Pro Thr Leu Ser Ser Ser Pro
        2995                3000                3005            
Glu Ile Asn Pro Glu Thr Gln Ala Ala Leu Ile Arg Gly Gln Asp Ser
    3010                3015                3020                
Thr Ile Ala Ala Ser Glu Gln Gln Val Ala Ala Arg Ile Leu Asp Ser
3025                3030                3035                3040
Asn Asp Gln Ala Thr Val Asn Pro Val Glu Phe Asn Thr Glu Val Ala
                3045                3050                3055    
Thr Pro Pro Phe Ser Leu Leu Glu Thr Ser Asn Glu Thr Asp Phe Leu
            3060                3065                3070        
Ile Gly Ile Asn Glu Glu Ser Val Glu Gly Thr Ala Ile Tyr Leu Pro
        3075                3080                3085            
Gly Pro Asp Arg Cys Lys Met Asn Pro Cys Leu Asn Gly Gly Thr Cys
    3090                3095                3100                
Tyr Pro Thr Glu Thr Ser Tyr Val Cys Thr Cys Val Pro Gly Tyr Ser
3105                3110                3115                3120
Gly Asp Gln Cys Glu Leu Asp Phe Asp Glu Cys His Ser Asn Pro Cys
                3125                3130                3135    
Arg Asn Gly Ala Thr Cys Val Asp Gly Phe Asn Thr Phe Arg Cys Leu
            3140                3145                3150        
Cys Leu Pro Ser Tyr Val Gly Ala Leu Cys Glu Gln Asp Thr Glu Thr
        3155                3160                3165            
Cys Asp Tyr Gly Trp His Lys Phe Gln Gly Gln Cys Tyr Lys Tyr Phe
    3170                3175                3180                
Ala His Arg Arg Thr Trp Asp Ala Ala Glu Arg Glu Cys Arg Leu Gln
3185                3190                3195                3200
Gly Ala His Leu Thr Ser Ile Leu Ser His Glu Glu Gln Met Phe Val
                3205                3210                3215    
Asn Arg Val Gly His Asp Tyr Gln Trp Ile Gly Leu Asn Asp Lys Met
            3220                3225                3230        
Phe Glu His Asp Phe Arg Trp Thr Asp Gly Ser Thr Leu Gln Tyr Glu
        3235                3240                3245            
Asn Trp Arg Pro Asn Gln Pro Asp Ser Phe Phe Ser Ala Gly Glu Asp
    3250                3255                3260                
Cys Val Val Ile Ile Trp His Glu Asn Gly Gln Trp Asn Asp Val Pro
3265                3270                3275                3280
Cys Asn Tyr His Leu Thr Tyr Thr Cys Lys Lys Gly Thr Val Ala Cys
                3285                3290                3295    
Gly Gln Pro Pro Val Val Glu Asn Ala Lys Thr Phe Gly Lys Met Lys
            3300                3305                3310        
Pro Arg Tyr Glu Ile Asn Ser Leu Ile Arg Tyr His Cys Lys Asp Gly
        3315                3320                3325            
Phe Ile Gln Arg His Leu Pro Thr Ile Arg Cys Leu Gly Asn Gly Arg
    3330                3335                3340                
Trp Ala Ile Pro Lys Ile Thr Cys Met Asn Pro Ser Ala Tyr Gln Arg
3345                3350                3355                3360
Thr Tyr Ser Met Lys Tyr Phe Lys Asn Ser Ser Ser Ala Lys Asp Asn
                3365                3370                3375    
Ser Ile Asn Thr Ser Lys His Asp His Arg Trp Ser Arg Arg Trp Gln
            3380                3385                3390        
Glu Ser Arg Arg
        3395    


<210> 9069
<211> 3370
<212> PRT
<213> Homo sapiens

<400> 9069
Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile
 1               5                  10                  15      
Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val
            20                  25                  30          
Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr
        35                  40                  45              
Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile
    50                  55                  60                  
Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu
65                  70                  75                  80  
Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp
                85                  90                  95      
Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp
            100                 105                 110         
Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr
        115                 120                 125             
Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser
    130                 135                 140                 
Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg
145                 150                 155                 160 
Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly
                165                 170                 175     
Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly
            180                 185                 190         
Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr
        195                 200                 205             
Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys
    210                 215                 220                 
Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp
225                 230                 235                 240 
Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr
                245                 250                 255     
Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn
            260                 265                 270         
Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg
        275                 280                 285             
Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val
    290                 295                 300                 
Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu
305                 310                 315                 320 
Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro
                325                 330                 335     
Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr
            340                 345                 350         
Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser
        355                 360                 365             
Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu
    370                 375                 380                 
Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn
385                 390                 395                 400 
Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr
                405                 410                 415     
Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys
            420                 425                 430         
Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly
        435                 440                 445             
Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr
    450                 455                 460                 
Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp
465                 470                 475                 480 
Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly
                485                 490                 495     
Pro Leu Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu
            500                 505                 510         
Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu
        515                 520                 525             
Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr
    530                 535                 540                 
Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg
545                 550                 555                 560 
Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile
                565                 570                 575     
Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr
            580                 585                 590         
His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro
        595                 600                 605             
Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu
    610                 615                 620                 
Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu
625                 630                 635                 640 
Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe
                645                 650                 655     
Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile
            660                 665                 670         
Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu
        675                 680                 685             
Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln
    690                 695                 700                 
Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val
705                 710                 715                 720 
Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val
                725                 730                 735     
Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu
            740                 745                 750         
Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu
        755                 760                 765             
Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr
    770                 775                 780                 
Thr Val Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val
785                 790                 795                 800 
Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu
                805                 810                 815     
Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr
            820                 825                 830         
Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu
        835                 840                 845             
Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln
    850                 855                 860                 
Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr
865                 870                 875                 880 
Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr
                885                 890                 895     
Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr
            900                 905                 910         
Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val
        915                 920                 925             
Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala
    930                 935                 940                 
His Thr Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr
945                 950                 955                 960 
Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser
                965                 970                 975     
Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser
            980                 985                 990         
Glu Asp Glu Val Leu Gly Glu Pro Ser Gln Asp Ile Leu Val Ile Asp
        995                 1000                1005            
Gln Thr Arg Leu Glu Ala Thr Ile Ser Pro Glu Thr Met Arg Thr Thr
    1010                1015                1020                
Lys Ile Thr Glu Gly Thr Thr Gln Glu Glu Phe Pro Trp Lys Glu Gln
1025                1030                1035                1040
Thr Ala Glu Lys Pro Val Pro Ala Leu Ser Ser Thr Ala Trp Thr Pro
                1045                1050                1055    
Lys Glu Ala Val Thr Pro Leu Asp Glu Gln Glu Gly Asp Gly Ser Ala
            1060                1065                1070        
Tyr Thr Val Ser Glu Asp Glu Leu Leu Thr Gly Ser Glu Arg Val Pro
        1075                1080                1085            
Val Leu Glu Thr Thr Pro Val Gly Lys Ile Asp His Ser Val Ser Tyr
    1090                1095                1100                
Pro Pro Gly Ala Val Thr Glu His Lys Val Lys Thr Asp Glu Val Val
1105                1110                1115                1120
Thr Leu Thr Pro Arg Ile Gly Pro Lys Val Ser Leu Ser Pro Gly Pro
                1125                1130                1135    
Glu Gln Lys Tyr Glu Thr Glu Gly Ser Ser Thr Thr Gly Phe Thr Ser
            1140                1145                1150        
Ser Leu Ser Pro Phe Ser Thr His Ile Thr Gln Leu Met Glu Glu Thr
        1155                1160                1165            
Thr Thr Glu Lys Thr Ser Leu Glu Asp Ile Asp Leu Gly Ser Gly Leu
    1170                1175                1180                
Phe Glu Lys Pro Lys Ala Thr Glu Leu Ile Glu Phe Ser Thr Ile Lys
1185                1190                1195                1200
Val Thr Val Pro Ser Asp Ile Thr Thr Ala Phe Ser Ser Val Asp Arg
                1205                1210                1215    
Leu His Thr Thr Ser Ala Phe Lys Pro Ser Ser Ala Ile Thr Lys Lys
            1220                1225                1230        
Pro Pro Leu Ile Asp Arg Glu Pro Gly Glu Glu Thr Thr Ser Asp Met
        1235                1240                1245            
Val Ile Ile Gly Glu Ser Thr Ser His Val Pro Pro Thr Thr Leu Glu
    1250                1255                1260                
Asp Ile Val Ala Lys Glu Thr Glu Thr Asp Ile Asp Arg Glu Tyr Phe
1265                1270                1275                1280
Thr Thr Ser Ser Pro Pro Ala Thr Gln Pro Thr Arg Pro Pro Thr Val
                1285                1290                1295    
Glu Asp Lys Glu Ala Phe Gly Pro Gln Ala Leu Ser Thr Pro Gln Pro
            1300                1305                1310        
Pro Ala Ser Thr Lys Phe His Pro Asp Ile Asn Val Tyr Ile Ile Glu
        1315                1320                1325            
Val Arg Glu Asn Lys Thr Gly Arg Met Ser Asp Leu Ser Val Ile Gly
    1330                1335                1340                
His Pro Ile Asp Ser Glu Ser Lys Glu Asp Glu Pro Cys Ser Glu Glu
1345                1350                1355                1360
Thr Asp Pro Val His Asp Leu Met Ala Glu Ile Leu Pro Glu Phe Pro
                1365                1370                1375    
Asp Ile Ile Glu Ile Asp Leu Tyr His Ser Glu Glu Asn Glu Glu Glu
            1380                1385                1390        
Glu Glu Glu Cys Ala Asn Ala Thr Asp Val Thr Thr Thr Pro Ser Val
        1395                1400                1405            
Gln Tyr Ile Asn Gly Lys His Leu Val Thr Thr Val Pro Lys Asp Pro
    1410                1415                1420                
Glu Ala Ala Glu Ala Arg Arg Gly Gln Phe Glu Ser Val Ala Pro Ser
1425                1430                1435                1440
Gln Asn Phe Ser Asp Ser Ser Glu Ser Asp Thr His Pro Phe Val Ile
                1445                1450                1455    
Ala Lys Thr Glu Leu Ser Thr Ala Val Gln Pro Asn Glu Ser Thr Glu
            1460                1465                1470        
Thr Thr Glu Ser Leu Glu Val Thr Trp Lys Pro Glu Thr Tyr Pro Glu
        1475                1480                1485            
Thr Ser Glu His Phe Ser Gly Gly Glu Pro Asp Val Phe Pro Thr Val
    1490                1495                1500                
Pro Phe His Glu Glu Phe Glu Ser Gly Thr Ala Lys Lys Gly Ala Glu
1505                1510                1515                1520
Ser Val Thr Glu Arg Asp Thr Glu Val Gly His Gln Ala His Glu His
                1525                1530                1535    
Thr Glu Pro Val Ser Leu Phe Pro Glu Glu Ser Ser Gly Glu Ile Ala
            1540                1545                1550        
Ile Asp Gln Glu Ser Gln Lys Ile Ala Phe Ala Arg Ala Thr Glu Val
        1555                1560                1565            
Thr Phe Gly Glu Glu Val Glu Lys Ser Thr Ser Val Thr Tyr Thr Pro
    1570                1575                1580                
Thr Ile Val Pro Ser Ser Ala Ser Ala Tyr Val Ser Glu Glu Glu Ala
1585                1590                1595                1600
Val Thr Leu Ile Gly Asn Pro Trp Pro Asp Asp Leu Leu Ser Thr Lys
                1605                1610                1615    
Glu Ser Trp Val Glu Ala Thr Pro Arg Gln Val Val Glu Leu Ser Gly
            1620                1625                1630        
Ser Ser Ser Ile Pro Ile Thr Glu Gly Ser Gly Glu Ala Glu Glu Asp
        1635                1640                1645            
Glu Asp Thr Met Phe Thr Met Val Thr Asp Leu Ser Gln Arg Asn Thr
    1650                1655                1660                
Thr Asp Thr Leu Ile Thr Leu Asp Thr Ser Arg Ile Ile Thr Glu Ser
1665                1670                1675                1680
Phe Phe Glu Val Pro Ala Thr Thr Ile Tyr Pro Val Ser Glu Gln Pro
                1685                1690                1695    
Ser Ala Lys Val Val Pro Thr Lys Phe Val Ser Glu Thr Asp Thr Ser
            1700                1705                1710        
Glu Trp Ile Ser Ser Thr Thr Val Glu Glu Lys Lys Arg Lys Glu Glu
        1715                1720                1725            
Glu Gly Thr Thr Gly Thr Ala Ser Thr Phe Glu Val Tyr Ser Ser Thr
    1730                1735                1740                
Gln Arg Ser Asp Gln Leu Ile Leu Pro Phe Glu Leu Glu Ser Pro Asn
1745                1750                1755                1760
Val Ala Thr Ser Ser Asp Ser Gly Thr Arg Lys Ser Phe Met Ser Leu
                1765                1770                1775    
Thr Thr Pro Thr Gln Ser Glu Arg Glu Met Thr Asp Ser Thr Pro Val
            1780                1785                1790        
Phe Thr Glu Thr Asn Thr Leu Glu Asn Leu Gly Ala Gln Thr Thr Glu
        1795                1800                1805            
His Ser Ser Ile His Gln Pro Gly Val Gln Glu Gly Leu Thr Thr Leu
    1810                1815                1820                
Pro Arg Ser Pro Ala Ser Val Phe Met Glu Gln Gly Ser Gly Glu Ala
1825                1830                1835                1840
Ala Ala Asp Pro Glu Thr Thr Thr Val Ser Ser Phe Ser Leu Asn Val
                1845                1850                1855    
Glu Tyr Ala Ile Gln Ala Glu Lys Glu Val Ala Gly Thr Leu Ser Pro
            1860                1865                1870        
His Val Glu Thr Thr Phe Ser Thr Glu Pro Thr Gly Leu Val Leu Ser
        1875                1880                1885            
Thr Val Met Asp Arg Val Val Ala Glu Asn Ile Thr Gln Thr Ser Arg
    1890                1895                1900                
Glu Ile Val Ile Ser Glu Arg Leu Gly Glu Pro Asn Tyr Gly Ala Glu
1905                1910                1915                1920
Ile Arg Gly Phe Ser Thr Gly Phe Pro Leu Glu Glu Asp Phe Ser Gly
                1925                1930                1935    
Asp Phe Arg Glu Tyr Ser Thr Val Ser His Pro Ile Ala Lys Glu Glu
            1940                1945                1950        
Thr Val Met Met Glu Gly Ser Gly Asp Ala Ala Phe Arg Asp Thr Gln
        1955                1960                1965            
Thr Ser Pro Ser Thr Val Pro Thr Ser Val His Ile Ser His Ile Ser
    1970                1975                1980                
Asp Ser Glu Gly Pro Ser Ser Thr Met Val Ser Thr Ser Ala Phe Pro
1985                1990                1995                2000
Trp Glu Glu Phe Thr Ser Ser Ala Glu Gly Ser Gly Glu Gln Leu Val
                2005                2010                2015    
Thr Val Ser Ser Ser Val Val Pro Val Leu Pro Ser Ala Val Gln Lys
            2020                2025                2030        
Phe Ser Gly Thr Ala Ser Ser Ile Ile Asp Glu Gly Leu Gly Glu Val
        2035                2040                2045            
Gly Thr Val Asn Glu Ile Asp Arg Arg Ser Thr Ile Leu Pro Thr Ala
    2050                2055                2060                
Glu Val Glu Gly Thr Lys Ala Pro Val Glu Lys Glu Glu Val Lys Val
2065                2070                2075                2080
Ser Gly Thr Val Ser Thr Asn Phe Pro Gln Thr Ile Glu Pro Ala Lys
                2085                2090                2095    
Leu Trp Ser Arg Gln Glu Val Asn Pro Val Arg Gln Glu Ile Glu Ser
            2100                2105                2110        
Glu Thr Thr Ser Glu Glu Gln Ile Gln Glu Glu Lys Ser Phe Glu Ser
        2115                2120                2125            
Pro Gln Asn Ser Pro Ala Thr Glu Gln Thr Ile Phe Asp Ser Gln Thr
    2130                2135                2140                
Phe Thr Glu Thr Glu Leu Lys Thr Thr Asp Tyr Ser Val Leu Thr Thr
2145                2150                2155                2160
Lys Lys Thr Tyr Ser Asp Asp Lys Glu Met Lys Glu Glu Asp Thr Ser
                2165                2170                2175    
Leu Val Asn Met Ser Thr Pro Asp Pro Asp Ala Asn Gly Leu Glu Ser
            2180                2185                2190        
Tyr Thr Thr Leu Pro Glu Ala Thr Glu Lys Ser His Phe Phe Leu Ala
        2195                2200                2205            
Thr Ala Leu Val Thr Glu Ser Ile Pro Ala Glu His Val Val Thr Asp
    2210                2215                2220                
Ser Pro Ile Lys Lys Glu Glu Ser Thr Lys His Phe Pro Lys Gly Met
2225                2230                2235                2240
Arg Pro Thr Ile Gln Glu Ser Asp Thr Glu Leu Leu Phe Ser Gly Leu
                2245                2250                2255    
Gly Ser Gly Glu Glu Val Leu Pro Thr Leu Pro Thr Glu Ser Val Asn
            2260                2265                2270        
Phe Thr Glu Val Glu Gln Ile Asn Asn Thr Leu Tyr Pro His Thr Ser
        2275                2280                2285            
Gln Val Glu Ser Thr Ser Ser Asp Lys Ile Glu Asp Phe Asn Arg Met
    2290                2295                2300                
Glu Asn Val Ala Lys Glu Val Gly Pro Leu Val Ser Gln Thr Asp Ile
2305                2310                2315                2320
Phe Glu Gly Ser Gly Ser Val Thr Ser Thr Thr Leu Ile Glu Ile Leu
                2325                2330                2335    
Ser Asp Thr Gly Ala Glu Gly Pro Thr Val Ala Pro Leu Pro Phe Ser
            2340                2345                2350        
Thr Asp Ile Gly His Pro Gln Asn Gln Thr Val Arg Trp Ala Glu Glu
        2355                2360                2365            
Ile Gln Thr Ser Arg Pro Gln Thr Ile Thr Glu Gln Asp Ser Asn Lys
    2370                2375                2380                
Asn Ser Ser Thr Ala Glu Ile Asn Glu Thr Thr Thr Ser Ser Thr Asp
2385                2390                2395                2400
Phe Leu Ala Arg Ala Tyr Gly Phe Glu Met Ala Lys Glu Phe Val Thr
                2405                2410                2415    
Ser Ala Pro Lys Pro Ser Asp Leu Tyr Tyr Glu Pro Ser Gly Glu Gly
            2420                2425                2430        
Ser Gly Glu Val Asp Ile Val Asp Ser Phe His Thr Ser Ala Thr Thr
        2435                2440                2445            
Gln Ala Thr Arg Gln Glu Ser Ser Thr Thr Phe Val Ser Asp Gly Ser
    2450                2455                2460                
Leu Glu Lys His Pro Glu Val Pro Ser Ala Lys Ala Val Thr Ala Asp
2465                2470                2475                2480
Gly Phe Pro Thr Val Ser Val Met Leu Pro Leu His Ser Glu Gln Asn
                2485                2490                2495    
Lys Ser Ser Pro Asp Pro Thr Ser Thr Leu Ser Asn Thr Val Ser Tyr
            2500                2505                2510        
Glu Arg Ser Thr Asp Gly Ser Phe Gln Asp Arg Phe Arg Glu Phe Glu
        2515                2520                2525            
Asp Ser Thr Leu Lys Pro Asn Arg Lys Lys Pro Thr Glu Asn Ile Ile
    2530                2535                2540                
Ile Asp Leu Asp Lys Glu Asp Lys Asp Leu Ile Leu Thr Ile Thr Glu
2545                2550                2555                2560
Ser Thr Ile Leu Glu Ile Leu Pro Glu Leu Thr Ser Asp Lys Asn Thr
                2565                2570                2575    
Ile Ile Asp Ile Asp His Thr Lys Pro Val Tyr Glu Asp Ile Leu Gly
            2580                2585                2590        
Met Gln Thr Asp Ile Asp Thr Glu Val Pro Ser Glu Pro His Asp Ser
        2595                2600                2605            
Asn Asp Glu Ser Asn Asp Asp Ser Thr Gln Val Gln Glu Ile Tyr Glu
    2610                2615                2620                
Ala Ala Val Asn Leu Ser Leu Thr Glu Glu Thr Phe Glu Gly Ser Ala
2625                2630                2635                2640
Asp Val Leu Ala Ser Tyr Thr Gln Ala Thr His Asp Glu Ser Met Thr
                2645                2650                2655    
Tyr Glu Asp Arg Ser Gln Leu Asp His Met Gly Phe His Phe Thr Thr
            2660                2665                2670        
Gly Ile Pro Ala Pro Ser Thr Glu Thr Glu Leu Asp Val Leu Leu Pro
        2675                2680                2685            
Thr Ala Thr Ser Leu Pro Ile Pro Arg Lys Ser Ala Thr Val Ile Pro
    2690                2695                2700                
Glu Ile Glu Gly Ile Lys Ala Glu Ala Lys Ala Leu Asp Asp Met Phe
2705                2710                2715                2720
Glu Ser Ser Thr Leu Ser Asp Gly Gln Ala Ile Ala Asp Gln Ser Glu
                2725                2730                2735    
Ile Ile Pro Thr Leu Gly Gln Phe Glu Arg Thr Gln Glu Glu Tyr Glu
            2740                2745                2750        
Asp Lys Lys His Ala Gly Pro Ser Phe Gln Pro Glu Phe Ser Ser Gly
        2755                2760                2765            
Ala Glu Glu Ala Leu Val Asp His Thr Pro Tyr Leu Ser Ile Ala Thr
    2770                2775                2780                
Thr His Leu Met Asp Gln Ser Val Thr Glu Val Pro Asp Val Met Glu
2785                2790                2795                2800
Gly Ser Asn Pro Pro Tyr Tyr Thr Asp Thr Thr Leu Ala Val Ser Thr
                2805                2810                2815    
Phe Ala Lys Leu Ser Ser Gln Thr Pro Ser Ser Pro Leu Thr Ile Tyr
            2820                2825                2830        
Ser Gly Ser Glu Ala Ser Gly His Thr Glu Ile Pro Gln Pro Ser Ala
        2835                2840                2845            
Leu Pro Gly Ile Asp Val Gly Ser Ser Val Met Ser Pro Gln Asp Ser
    2850                2855                2860                
Phe Lys Glu Ile His Val Asn Ile Glu Ala Thr Phe Lys Pro Ser Ser
2865                2870                2875                2880
Glu Glu Tyr Leu His Ile Thr Glu Pro Pro Ser Leu Ser Pro Asp Thr
                2885                2890                2895    
Lys Leu Glu Pro Ser Glu Asp Asp Gly Lys Pro Glu Leu Leu Glu Glu
            2900                2905                2910        
Met Glu Ala Ser Pro Thr Glu Leu Ile Ala Val Glu Gly Thr Glu Ile
        2915                2920                2925            
Leu Gln Asp Phe Gln Asn Lys Thr Asp Gly Gln Val Ser Gly Glu Ala
    2930                2935                2940                
Ile Lys Met Phe Pro Thr Ile Lys Thr Pro Glu Ala Gly Thr Val Ile
2945                2950                2955                2960
Thr Thr Ala Asp Glu Ile Glu Leu Glu Gly Ala Thr Gln Trp Pro His
                2965                2970                2975    
Ser Thr Ser Ala Ser Ala Thr Tyr Gly Val Glu Ala Gly Val Val Pro
            2980                2985                2990        
Trp Leu Ser Pro Gln Thr Ser Glu Arg Pro Thr Leu Ser Ser Ser Pro
        2995                3000                3005            
Glu Ile Asn Pro Glu Thr Gln Ala Ala Leu Ile Arg Gly Gln Asp Ser
    3010                3015                3020                
Thr Ile Ala Ala Ser Glu Gln Gln Val Ala Ala Arg Ile Leu Asp Ser
3025                3030                3035                3040
Asn Asp Gln Ala Thr Val Asn Pro Val Glu Phe Asn Thr Glu Val Ala
                3045                3050                3055    
Thr Pro Pro Phe Ser Leu Leu Glu Thr Ser Asn Glu Thr Asp Phe Leu
            3060                3065                3070        
Ile Gly Ile Asn Glu Glu Ser Val Glu Gly Thr Ala Ile Tyr Leu Pro
        3075                3080                3085            
Gly Pro Asp Arg Cys Lys Met Asn Pro Cys Leu Asn Gly Gly Thr Cys
    3090                3095                3100                
Tyr Pro Thr Glu Thr Ser Tyr Val Cys Thr Cys Val Pro Gly Tyr Ser
3105                3110                3115                3120
Gly Asp Gln Cys Glu Leu Asp Phe Asp Glu Cys His Ser Asn Pro Cys
                3125                3130                3135    
Arg Asn Gly Ala Thr Cys Val Asp Gly Phe Asn Thr Phe Arg Cys Leu
            3140                3145                3150        
Cys Leu Pro Ser Tyr Val Gly Ala Leu Cys Glu Gln Asp Thr Glu Thr
        3155                3160                3165            
Cys Asp Tyr Gly Trp His Lys Phe Gln Gly Gln Cys Tyr Lys Tyr Phe
    3170                3175                3180                
Ala His Arg Arg Thr Trp Asp Ala Ala Glu Arg Glu Cys Arg Leu Gln
3185                3190                3195                3200
Gly Ala His Leu Thr Ser Ile Leu Ser His Glu Glu Gln Met Phe Val
                3205                3210                3215    
Asn Arg Val Gly His Asp Tyr Gln Trp Ile Gly Leu Asn Asp Lys Met
            3220                3225                3230        
Phe Glu His Asp Phe Arg Trp Thr Asp Gly Ser Thr Leu Gln Tyr Glu
        3235                3240                3245            
Asn Trp Arg Pro Asn Gln Pro Asp Ser Phe Phe Ser Ala Gly Glu Asp
    3250                3255                3260                
Cys Val Val Ile Ile Trp His Glu Asn Gly Gln Trp Asn Asp Val Pro
3265                3270                3275                3280
Cys Asn Tyr His Leu Thr Tyr Thr Cys Lys Lys Gly Thr Val Ala Cys
                3285                3290                3295    
Gly Gln Pro Pro Val Val Glu Asn Ala Lys Thr Phe Gly Lys Met Lys
            3300                3305                3310        
Pro Arg Tyr Glu Ile Asn Ser Leu Ile Arg Tyr His Cys Lys Asp Gly
        3315                3320                3325            
Phe Ile Gln Arg His Leu Pro Thr Ile Arg Cys Leu Gly Asn Gly Arg
    3330                3335                3340                
Trp Ala Ile Pro Lys Ile Thr Cys Met Asn Arg Lys Trp Ser Phe Arg
3345                3350                3355                3360
Lys Asn Gly Leu Pro Cys Tyr Asn Asn Tyr
                3365                3370


<210> 9070
<211> 2409
<212> PRT
<213> Homo sapiens

<400> 9070
Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile
 1               5                  10                  15      
Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val
            20                  25                  30          
Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr
        35                  40                  45              
Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile
    50                  55                  60                  
Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu
65                  70                  75                  80  
Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp
                85                  90                  95      
Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp
            100                 105                 110         
Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr
        115                 120                 125             
Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser
    130                 135                 140                 
Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg
145                 150                 155                 160 
Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly
                165                 170                 175     
Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly
            180                 185                 190         
Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr
        195                 200                 205             
Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys
    210                 215                 220                 
Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp
225                 230                 235                 240 
Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr
                245                 250                 255     
Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn
            260                 265                 270         
Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg
        275                 280                 285             
Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val
    290                 295                 300                 
Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu
305                 310                 315                 320 
Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro
                325                 330                 335     
Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Arg Arg Met Ser Asp
            340                 345                 350         
Leu Ser Val Ile Gly His Pro Ile Asp Ser Glu Ser Lys Glu Asp Glu
        355                 360                 365             
Pro Cys Ser Glu Glu Thr Asp Pro Val His Asp Leu Met Ala Glu Ile
    370                 375                 380                 
Leu Pro Glu Phe Pro Asp Ile Ile Glu Ile Asp Leu Tyr His Ser Glu
385                 390                 395                 400 
Glu Asn Glu Glu Glu Glu Glu Glu Cys Ala Asn Ala Thr Asp Val Thr
                405                 410                 415     
Thr Thr Pro Ser Val Gln Tyr Ile Asn Gly Lys His Leu Val Thr Thr
            420                 425                 430         
Val Pro Lys Asp Pro Glu Ala Ala Glu Ala Arg Arg Gly Gln Phe Glu
        435                 440                 445             
Ser Val Ala Pro Ser Gln Asn Phe Ser Asp Ser Ser Glu Ser Asp Thr
    450                 455                 460                 
His Pro Phe Val Ile Ala Lys Thr Glu Leu Ser Thr Ala Val Gln Pro
465                 470                 475                 480 
Asn Glu Ser Thr Glu Thr Thr Glu Ser Leu Glu Val Thr Trp Lys Pro
                485                 490                 495     
Glu Thr Tyr Pro Glu Thr Ser Glu His Phe Ser Gly Gly Glu Pro Asp
            500                 505                 510         
Val Phe Pro Thr Val Pro Phe His Glu Glu Phe Glu Ser Gly Thr Ala
        515                 520                 525             
Lys Lys Gly Ala Glu Ser Val Thr Glu Arg Asp Thr Glu Val Gly His
    530                 535                 540                 
Gln Ala His Glu His Thr Glu Pro Val Ser Leu Phe Pro Glu Glu Ser
545                 550                 555                 560 
Ser Gly Glu Ile Ala Ile Asp Gln Glu Ser Gln Lys Ile Ala Phe Ala
                565                 570                 575     
Arg Ala Thr Glu Val Thr Phe Gly Glu Glu Val Glu Lys Ser Thr Ser
            580                 585                 590         
Val Thr Tyr Thr Pro Thr Ile Val Pro Ser Ser Ala Ser Ala Tyr Val
        595                 600                 605             
Ser Glu Glu Glu Ala Val Thr Leu Ile Gly Asn Pro Trp Pro Asp Asp
    610                 615                 620                 
Leu Leu Ser Thr Lys Glu Ser Trp Val Glu Ala Thr Pro Arg Gln Val
625                 630                 635                 640 
Val Glu Leu Ser Gly Ser Ser Ser Ile Pro Ile Thr Glu Gly Ser Gly
                645                 650                 655     
Glu Ala Glu Glu Asp Glu Asp Thr Met Phe Thr Met Val Thr Asp Leu
            660                 665                 670         
Ser Gln Arg Asn Thr Thr Asp Thr Leu Ile Thr Leu Asp Thr Ser Arg
        675                 680                 685             
Ile Ile Thr Glu Ser Phe Phe Glu Val Pro Ala Thr Thr Ile Tyr Pro
    690                 695                 700                 
Val Ser Glu Gln Pro Ser Ala Lys Val Val Pro Thr Lys Phe Val Ser
705                 710                 715                 720 
Glu Thr Asp Thr Ser Glu Trp Ile Ser Ser Thr Thr Val Glu Glu Lys
                725                 730                 735     
Lys Arg Lys Glu Glu Glu Gly Thr Thr Gly Thr Ala Ser Thr Phe Glu
            740                 745                 750         
Val Tyr Ser Ser Thr Gln Arg Ser Asp Gln Leu Ile Leu Pro Phe Glu
        755                 760                 765             
Leu Glu Ser Pro Asn Val Ala Thr Ser Ser Asp Ser Gly Thr Arg Lys
    770                 775                 780                 
Ser Phe Met Ser Leu Thr Thr Pro Thr Gln Ser Glu Arg Glu Met Thr
785                 790                 795                 800 
Asp Ser Thr Pro Val Phe Thr Glu Thr Asn Thr Leu Glu Asn Leu Gly
                805                 810                 815     
Ala Gln Thr Thr Glu His Ser Ser Ile His Gln Pro Gly Val Gln Glu
            820                 825                 830         
Gly Leu Thr Thr Leu Pro Arg Ser Pro Ala Ser Val Phe Met Glu Gln
        835                 840                 845             
Gly Ser Gly Glu Ala Ala Ala Asp Pro Glu Thr Thr Thr Val Ser Ser
    850                 855                 860                 
Phe Ser Leu Asn Val Glu Tyr Ala Ile Gln Ala Glu Lys Glu Val Ala
865                 870                 875                 880 
Gly Thr Leu Ser Pro His Val Glu Thr Thr Phe Ser Thr Glu Pro Thr
                885                 890                 895     
Gly Leu Val Leu Ser Thr Val Met Asp Arg Val Val Ala Glu Asn Ile
            900                 905                 910         
Thr Gln Thr Ser Arg Glu Ile Val Ile Ser Glu Arg Leu Gly Glu Pro
        915                 920                 925             
Asn Tyr Gly Ala Glu Ile Arg Gly Phe Ser Thr Gly Phe Pro Leu Glu
    930                 935                 940                 
Glu Asp Phe Ser Gly Asp Phe Arg Glu Tyr Ser Thr Val Ser His Pro
945                 950                 955                 960 
Ile Ala Lys Glu Glu Thr Val Met Met Glu Gly Ser Gly Asp Ala Ala
                965                 970                 975     
Phe Arg Asp Thr Gln Thr Ser Pro Ser Thr Val Pro Thr Ser Val His
            980                 985                 990         
Ile Ser His Ile Ser Asp Ser Glu Gly Pro Ser Ser Thr Met Val Ser
        995                 1000                1005            
Thr Ser Ala Phe Pro Trp Glu Glu Phe Thr Ser Ser Ala Glu Gly Ser
    1010                1015                1020                
Gly Glu Gln Leu Val Thr Val Ser Ser Ser Val Val Pro Val Leu Pro
1025                1030                1035                1040
Ser Ala Val Gln Lys Phe Ser Gly Thr Ala Ser Ser Ile Ile Asp Glu
                1045                1050                1055    
Gly Leu Gly Glu Val Gly Thr Val Asn Glu Ile Asp Arg Arg Ser Thr
            1060                1065                1070        
Ile Leu Pro Thr Ala Glu Val Glu Gly Thr Lys Ala Pro Val Glu Lys
        1075                1080                1085            
Glu Glu Val Lys Val Ser Gly Thr Val Ser Thr Asn Phe Pro Gln Thr
    1090                1095                1100                
Ile Glu Pro Ala Lys Leu Trp Ser Arg Gln Glu Val Asn Pro Val Arg
1105                1110                1115                1120
Gln Glu Ile Glu Ser Glu Thr Thr Ser Glu Glu Gln Ile Gln Glu Glu
                1125                1130                1135    
Lys Ser Phe Glu Ser Pro Gln Asn Ser Pro Ala Thr Glu Gln Thr Ile
            1140                1145                1150        
Phe Asp Ser Gln Thr Phe Thr Glu Thr Glu Leu Lys Thr Thr Asp Tyr
        1155                1160                1165            
Ser Val Leu Thr Thr Lys Lys Thr Tyr Ser Asp Asp Lys Glu Met Lys
    1170                1175                1180                
Glu Glu Asp Thr Ser Leu Val Asn Met Ser Thr Pro Asp Pro Asp Ala
1185                1190                1195                1200
Asn Gly Leu Glu Ser Tyr Thr Thr Leu Pro Glu Ala Thr Glu Lys Ser
                1205                1210                1215    
His Phe Phe Leu Ala Thr Ala Leu Val Thr Glu Ser Ile Pro Ala Glu
            1220                1225                1230        
His Val Val Thr Asp Ser Pro Ile Lys Lys Glu Glu Ser Thr Lys His
        1235                1240                1245            
Phe Pro Lys Gly Met Arg Pro Thr Ile Gln Glu Ser Asp Thr Glu Leu
    1250                1255                1260                
Leu Phe Ser Gly Leu Gly Ser Gly Glu Glu Val Leu Pro Thr Leu Pro
1265                1270                1275                1280
Thr Glu Ser Val Asn Phe Thr Glu Val Glu Gln Ile Asn Asn Thr Leu
                1285                1290                1295    
Tyr Pro His Thr Ser Gln Val Glu Ser Thr Ser Ser Asp Lys Ile Glu
            1300                1305                1310        
Asp Phe Asn Arg Met Glu Asn Val Ala Lys Glu Val Gly Pro Leu Val
        1315                1320                1325            
Ser Gln Thr Asp Ile Phe Glu Gly Ser Gly Ser Val Thr Ser Thr Thr
    1330                1335                1340                
Leu Ile Glu Ile Leu Ser Asp Thr Gly Ala Glu Gly Pro Thr Val Ala
1345                1350                1355                1360
Pro Leu Pro Phe Ser Thr Asp Ile Gly His Pro Gln Asn Gln Thr Val
                1365                1370                1375    
Arg Trp Ala Glu Glu Ile Gln Thr Ser Arg Pro Gln Thr Ile Thr Glu
            1380                1385                1390        
Gln Asp Ser Asn Lys Asn Ser Ser Thr Ala Glu Ile Asn Glu Thr Thr
        1395                1400                1405            
Thr Ser Ser Thr Asp Phe Leu Ala Arg Ala Tyr Gly Phe Glu Met Ala
    1410                1415                1420                
Lys Glu Phe Val Thr Ser Ala Pro Lys Pro Ser Asp Leu Tyr Tyr Glu
1425                1430                1435                1440
Pro Ser Gly Glu Gly Ser Gly Glu Val Asp Ile Val Asp Ser Phe His
                1445                1450                1455    
Thr Ser Ala Thr Thr Gln Ala Thr Arg Gln Glu Ser Ser Thr Thr Phe
            1460                1465                1470        
Val Ser Asp Gly Ser Leu Glu Lys His Pro Glu Val Pro Ser Ala Lys
        1475                1480                1485            
Ala Val Thr Ala Asp Gly Phe Pro Thr Val Ser Val Met Leu Pro Leu
    1490                1495                1500                
His Ser Glu Gln Asn Lys Ser Ser Pro Asp Pro Thr Ser Thr Leu Ser
1505                1510                1515                1520
Asn Thr Val Ser Tyr Glu Arg Ser Thr Asp Gly Ser Phe Gln Asp Arg
                1525                1530                1535    
Phe Arg Glu Phe Glu Asp Ser Thr Leu Lys Pro Asn Arg Lys Lys Pro
            1540                1545                1550        
Thr Glu Asn Ile Ile Ile Asp Leu Asp Lys Glu Asp Lys Asp Leu Ile
        1555                1560                1565            
Leu Thr Ile Thr Glu Ser Thr Ile Leu Glu Ile Leu Pro Glu Leu Thr
    1570                1575                1580                
Ser Asp Lys Asn Thr Ile Ile Asp Ile Asp His Thr Lys Pro Val Tyr
1585                1590                1595                1600
Glu Asp Ile Leu Gly Met Gln Thr Asp Ile Asp Thr Glu Val Pro Ser
                1605                1610                1615    
Glu Pro His Asp Ser Asn Asp Glu Ser Asn Asp Asp Ser Thr Gln Val
            1620                1625                1630        
Gln Glu Ile Tyr Glu Ala Ala Val Asn Leu Ser Leu Thr Glu Glu Thr
        1635                1640                1645            
Phe Glu Gly Ser Ala Asp Val Leu Ala Ser Tyr Thr Gln Ala Thr His
    1650                1655                1660                
Asp Glu Ser Met Thr Tyr Glu Asp Arg Ser Gln Leu Asp His Met Gly
1665                1670                1675                1680
Phe His Phe Thr Thr Gly Ile Pro Ala Pro Ser Thr Glu Thr Glu Leu
                1685                1690                1695    
Asp Val Leu Leu Pro Thr Ala Thr Ser Leu Pro Ile Pro Arg Lys Ser
            1700                1705                1710        
Ala Thr Val Ile Pro Glu Ile Glu Gly Ile Lys Ala Glu Ala Lys Ala
        1715                1720                1725            
Leu Asp Asp Met Phe Glu Ser Ser Thr Leu Ser Asp Gly Gln Ala Ile
    1730                1735                1740                
Ala Asp Gln Ser Glu Ile Ile Pro Thr Leu Gly Gln Phe Glu Arg Thr
1745                1750                1755                1760
Gln Glu Glu Tyr Glu Asp Lys Lys His Ala Gly Pro Ser Phe Gln Pro
                1765                1770                1775    
Glu Phe Ser Ser Gly Ala Glu Glu Ala Leu Val Asp His Thr Pro Tyr
            1780                1785                1790        
Leu Ser Ile Ala Thr Thr His Leu Met Asp Gln Ser Val Thr Glu Val
        1795                1800                1805            
Pro Asp Val Met Glu Gly Ser Asn Pro Pro Tyr Tyr Thr Asp Thr Thr
    1810                1815                1820                
Leu Ala Val Ser Thr Phe Ala Lys Leu Ser Ser Gln Thr Pro Ser Ser
1825                1830                1835                1840
Pro Leu Thr Ile Tyr Ser Gly Ser Glu Ala Ser Gly His Thr Glu Ile
                1845                1850                1855    
Pro Gln Pro Ser Ala Leu Pro Gly Ile Asp Val Gly Ser Ser Val Met
            1860                1865                1870        
Ser Pro Gln Asp Ser Phe Lys Glu Ile His Val Asn Ile Glu Ala Thr
        1875                1880                1885            
Phe Lys Pro Ser Ser Glu Glu Tyr Leu His Ile Thr Glu Pro Pro Ser
    1890                1895                1900                
Leu Ser Pro Asp Thr Lys Leu Glu Pro Ser Glu Asp Asp Gly Lys Pro
1905                1910                1915                1920
Glu Leu Leu Glu Glu Met Glu Ala Ser Pro Thr Glu Leu Ile Ala Val
                1925                1930                1935    
Glu Gly Thr Glu Ile Leu Gln Asp Phe Gln Asn Lys Thr Asp Gly Gln
            1940                1945                1950        
Val Ser Gly Glu Ala Ile Lys Met Phe Pro Thr Ile Lys Thr Pro Glu
        1955                1960                1965            
Ala Gly Thr Val Ile Thr Thr Ala Asp Glu Ile Glu Leu Glu Gly Ala
    1970                1975                1980                
Thr Gln Trp Pro His Ser Thr Ser Ala Ser Ala Thr Tyr Gly Val Glu
1985                1990                1995                2000
Ala Gly Val Val Pro Trp Leu Ser Pro Gln Thr Ser Glu Arg Pro Thr
                2005                2010                2015    
Leu Ser Ser Ser Pro Glu Ile Asn Pro Glu Thr Gln Ala Ala Leu Ile
            2020                2025                2030        
Arg Gly Gln Asp Ser Thr Ile Ala Ala Ser Glu Gln Gln Val Ala Ala
        2035                2040                2045            
Arg Ile Leu Asp Ser Asn Asp Gln Ala Thr Val Asn Pro Val Glu Phe
    2050                2055                2060                
Asn Thr Glu Val Ala Thr Pro Pro Phe Ser Leu Leu Glu Thr Ser Asn
2065                2070                2075                2080
Glu Thr Asp Phe Leu Ile Gly Ile Asn Glu Glu Ser Val Glu Gly Thr
                2085                2090                2095    
Ala Ile Tyr Leu Pro Gly Pro Asp Arg Cys Lys Met Asn Pro Cys Leu
            2100                2105                2110        
Asn Gly Gly Thr Cys Tyr Pro Thr Glu Thr Ser Tyr Val Cys Thr Cys
        2115                2120                2125            
Val Pro Gly Tyr Ser Gly Asp Gln Cys Glu Leu Asp Phe Asp Glu Cys
    2130                2135                2140                
His Ser Asn Pro Cys Arg Asn Gly Ala Thr Cys Val Asp Gly Phe Asn
2145                2150                2155                2160
Thr Phe Arg Cys Leu Cys Leu Pro Ser Tyr Val Gly Ala Leu Cys Glu
                2165                2170                2175    
Gln Asp Thr Glu Thr Cys Asp Tyr Gly Trp His Lys Phe Gln Gly Gln
            2180                2185                2190        
Cys Tyr Lys Tyr Phe Ala His Arg Arg Thr Trp Asp Ala Ala Glu Arg
        2195                2200                2205            
Glu Cys Arg Leu Gln Gly Ala His Leu Thr Ser Ile Leu Ser His Glu
    2210                2215                2220                
Glu Gln Met Phe Val Asn Arg Val Gly His Asp Tyr Gln Trp Ile Gly
2225                2230                2235                2240
Leu Asn Asp Lys Met Phe Glu His Asp Phe Arg Trp Thr Asp Gly Ser
                2245                2250                2255    
Thr Leu Gln Tyr Glu Asn Trp Arg Pro Asn Gln Pro Asp Ser Phe Phe
            2260                2265                2270        
Ser Ala Gly Glu Asp Cys Val Val Ile Ile Trp His Glu Asn Gly Gln
        2275                2280                2285            
Trp Asn Asp Val Pro Cys Asn Tyr His Leu Thr Tyr Thr Cys Lys Lys
    2290                2295                2300                
Gly Thr Val Ala Cys Gly Gln Pro Pro Val Val Glu Asn Ala Lys Thr
2305                2310                2315                2320
Phe Gly Lys Met Lys Pro Arg Tyr Glu Ile Asn Ser Leu Ile Arg Tyr
                2325                2330                2335    
His Cys Lys Asp Gly Phe Ile Gln Arg His Leu Pro Thr Ile Arg Cys
            2340                2345                2350        
Leu Gly Asn Gly Arg Trp Ala Ile Pro Lys Ile Thr Cys Met Asn Pro
        2355                2360                2365            
Ser Ala Tyr Gln Arg Thr Tyr Ser Met Lys Tyr Phe Lys Asn Ser Ser
    2370                2375                2380                
Ser Ala Lys Asp Asn Ser Ile Asn Thr Ser Lys His Asp His Arg Trp
2385                2390                2395                2400
Ser Arg Arg Trp Gln Glu Ser Arg Arg
                2405                


<210> 9071
<211> 398
<212> PRT
<213> Homo sapiens

<400> 9071
Met His Leu Arg Ile His Ala Arg Arg Ser Pro Pro Arg Arg Pro Ala
 1               5                  10                  15      
Trp Thr Leu Gly Ile Trp Phe Leu Phe Trp Gly Cys Ile Val Ser Ser
            20                  25                  30          
Val Trp Ser Ser Ser Asn Val Ala Ser Ser Ser Ser Thr Ser Ser Ser
        35                  40                  45              
Pro Gly Ser His Ser Gln His Glu His His Phe His Gly Ser Lys His
    50                  55                  60                  
His Ser Val Pro Ile Ser Ile Tyr Arg Ser Pro Val Ser Leu Arg Gly
65                  70                  75                  80  
Gly His Ala Gly Ala Thr Tyr Ile Phe Gly Lys Ser Gly Gly Leu Ile
                85                  90                  95      
Leu Tyr Thr Trp Pro Ala Asn Asp Arg Pro Ser Thr Arg Ser Asp Arg
            100                 105                 110         
Leu Ala Val Gly Phe Ser Thr Thr Val Lys Asp Gly Ile Leu Val Arg
        115                 120                 125             
Ile Asp Ser Ala Pro Gly Leu Gly Asp Phe Leu Gln Leu His Ile Glu
    130                 135                 140                 
Gln Gly Lys Ile Gly Val Val Phe Asn Ile Gly Thr Val Asp Ile Ser
145                 150                 155                 160 
Ile Lys Glu Glu Arg Thr Pro Val Asn Asp Gly Lys Tyr His Val Val
                165                 170                 175     
Arg Phe Thr Arg Asn Gly Gly Asn Ala Thr Leu Gln Val Asp Asn Trp
            180                 185                 190         
Pro Val Asn Glu His Tyr Pro Thr Gly Asn Thr Asp Asn Glu Arg Phe
        195                 200                 205             
Gln Met Val Lys Gln Lys Ile Pro Phe Lys Tyr Asn Arg Pro Val Glu
    210                 215                 220                 
Glu Trp Leu Gln Glu Lys Gly Arg Gln Leu Thr Ile Phe Asn Thr Gln
225                 230                 235                 240 
Ala Gln Ile Ala Ile Gly Gly Lys Asp Lys Gly Arg Leu Phe Gln Gly
                245                 250                 255     
Gln Leu Ser Gly Leu Tyr Tyr Asp Gly Leu Lys Val Leu Asn Met Ala
            260                 265                 270         
Ala Glu Asn Asn Pro Asn Ile Lys Ile Asn Gly Ser Val Arg Leu Val
        275                 280                 285             
Gly Glu Val Pro Ser Ile Leu Gly Thr Thr Gln Thr Thr Ser Met Pro
    290                 295                 300                 
Pro Glu Met Ser Thr Thr Val Met Glu Thr Thr Thr Thr Met Ala Thr
305                 310                 315                 320 
Thr Thr Thr Arg Lys Asn Arg Ser Thr Ala Ser Ile Gln Pro Thr Ser
                325                 330                 335     
Asp Asp Leu Val Ser Ser Ala Glu Cys Ser Ser Asp Asp Glu Asp Phe
            340                 345                 350         
Val Glu Cys Glu Pro Ser Thr Gly Arg Ser Ala Arg Ser Ser Asn Ala
        355                 360                 365             
Ala Arg Ser Leu Arg Ala Ala Leu Thr Trp Thr Trp Arg Leu Thr Tyr
    370                 375                 380                 
Thr Phe Thr Pro Ile Ile Phe Ile Ser Cys Val Val His Ser
385                 390                 395             


<210> 9072
<211> 536
<212> PRT
<213> Homo sapiens

<400> 9072
Met His Leu Arg Ile His Ala Arg Arg Ser Pro Pro Arg Arg Pro Ala
 1               5                  10                  15      
Trp Thr Leu Gly Ile Trp Phe Leu Phe Trp Gly Cys Ile Val Ser Ser
            20                  25                  30          
Val Trp Ser Ser Ser Asn Val Ala Ser Ser Ser Ser Thr Ser Ser Ser
        35                  40                  45              
Pro Gly Ser His Ser Gln His Glu His His Phe His Gly Ser Lys His
    50                  55                  60                  
His Ser Val Pro Ile Ser Ile Tyr Arg Ser Pro Val Ser Leu Arg Gly
65                  70                  75                  80  
Gly His Ala Gly Ala Thr Tyr Ile Phe Gly Lys Ser Gly Gly Leu Ile
                85                  90                  95      
Leu Tyr Thr Trp Pro Ala Asn Asp Arg Pro Ser Thr Arg Ser Asp Arg
            100                 105                 110         
Leu Ala Val Gly Phe Ser Thr Thr Val Lys Asp Gly Ile Leu Val Arg
        115                 120                 125             
Ile Asp Ser Ala Pro Gly Leu Gly Asp Phe Leu Gln Leu His Ile Glu
    130                 135                 140                 
Gln Gly Lys Ile Gly Val Val Phe Asn Ile Gly Thr Val Asp Ile Ser
145                 150                 155                 160 
Ile Lys Glu Glu Arg Thr Pro Val Asn Asp Gly Lys Tyr His Val Val
                165                 170                 175     
Arg Phe Thr Arg Asn Gly Gly Asn Ala Thr Leu Gln Val Asp Asn Trp
            180                 185                 190         
Pro Val Asn Glu His Tyr Pro Thr Gly Arg Gln Leu Thr Ile Phe Asn
        195                 200                 205             
Thr Gln Ala Gln Ile Ala Ile Gly Gly Lys Asp Lys Gly Arg Leu Phe
    210                 215                 220                 
Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asp Gly Leu Lys Val Leu Asn
225                 230                 235                 240 
Met Ala Ala Glu Asn Asn Pro Asn Ile Lys Ile Asn Gly Ser Val Arg
                245                 250                 255     
Leu Val Gly Glu Val Pro Ser Ile Leu Gly Thr Thr Gln Thr Thr Ser
            260                 265                 270         
Met Pro Pro Glu Met Ser Thr Thr Val Met Glu Thr Thr Thr Thr Met
        275                 280                 285             
Ala Thr Thr Thr Thr Arg Lys Asn Arg Ser Thr Ala Ser Ile Gln Pro
    290                 295                 300                 
Thr Ser Asp Asp Leu Val Ser Ser Ala Glu Cys Ser Ser Asp Asp Glu
305                 310                 315                 320 
Asp Phe Val Glu Cys Glu Pro Ser Thr Asp Lys Ser Leu Ser Thr Ser
                325                 330                 335     
Ile Phe Glu Gly Gly Tyr Lys Ala His Ala Pro Lys Trp Glu Ser Lys
            340                 345                 350         
Asp Phe Arg Pro Asn Lys Val Ser Glu Thr Ser Arg Thr Thr Thr Thr
        355                 360                 365             
Ser Leu Ser Pro Glu Leu Ile Arg Phe Thr Ala Ser Ser Ser Ser Gly
    370                 375                 380                 
Met Val Pro Lys Leu Pro Ala Gly Lys Met Asn Asn Arg Asp Leu Lys
385                 390                 395                 400 
Pro Gln Pro Asp Ile Val Leu Leu Pro Leu Pro Thr Ala Tyr Glu Leu
                405                 410                 415     
Asp Ser Thr Lys Leu Lys Ser Pro Leu Ile Thr Ser Pro Met Phe Arg
            420                 425                 430         
Asn Val Pro Thr Ala Asn Pro Thr Glu Pro Gly Ile Arg Arg Val Pro
        435                 440                 445             
Gly Ala Ser Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val
    450                 455                 460                 
Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr
465                 470                 475                 480 
Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr Gln Val Asp
                485                 490                 495     
Glu Thr Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Thr Leu
            500                 505                 510         
Met Lys Glu Lys Gln Gln Ser Ser Lys Ser Gly His Lys Lys Gln Lys
        515                 520                 525             
Asn Lys Asp Arg Glu Tyr Tyr Val
    530                 535     


<210> 9073
<211> 1541
<212> PRT
<213> Homo sapiens

<400> 9073
Met Ser Ser Thr Leu His Ser Val Phe Phe Thr Leu Lys Val Ser Ile
 1               5                  10                  15      
Leu Leu Gly Ser Leu Leu Gly Leu Cys Leu Gly Leu Glu Phe Met Gly
            20                  25                  30          
Leu Pro Asn Gln Trp Ala Arg Tyr Leu Arg Trp Asp Ala Ser Thr Arg
        35                  40                  45              
Ser Asp Leu Ser Phe Gln Phe Lys Thr Asn Val Ser Thr Gly Leu Leu
    50                  55                  60                  
Leu Tyr Leu Asp Asp Gly Gly Val Cys Asp Phe Leu Cys Leu Ser Leu
65                  70                  75                  80  
Val Asp Gly Arg Val Gln Leu Arg Phe Ser Met Asp Cys Ala Glu Thr
                85                  90                  95      
Ala Val Leu Ser Asn Lys Gln Val Asn Asp Ser Ser Trp His Phe Leu
            100                 105                 110         
Met Val Ser Arg Asp Arg Leu Arg Thr Val Leu Met Leu Asp Gly Glu
        115                 120                 125             
Gly Gln Ser Gly Glu Leu Gln Pro Gln Arg Pro Tyr Met Asp Val Val
    130                 135                 140                 
Ser Asp Leu Phe Leu Gly Gly Val Pro Thr Asp Ile Arg Pro Ser Ala
145                 150                 155                 160 
Leu Thr Leu Asp Gly Val Gln Ala Met Pro Gly Phe Lys Gly Leu Ile
                165                 170                 175     
Leu Asp Leu Lys Tyr Gly Asn Ser Glu Pro Arg Leu Leu Gly Ser Arg
            180                 185                 190         
Gly Val Gln Met Asp Ala Glu Gly Pro Cys Gly Glu Arg Pro Cys Glu
        195                 200                 205             
Asn Gly Gly Ile Cys Phe Leu Leu Asp Gly His Pro Thr Cys Asp Cys
    210                 215                 220                 
Ser Thr Thr Gly Tyr Gly Gly Lys Leu Cys Ser Glu Asp Val Ser Gln
225                 230                 235                 240 
Asp Pro Gly Leu Ser His Leu Met Met Ser Glu Gln Ala Arg Glu Glu
                245                 250                 255     
Asn Val Ala Thr Phe Arg Gly Ser Glu Tyr Leu Cys Tyr Asp Leu Ser
            260                 265                 270         
Gln Asn Pro Ile Gln Ser Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys
        275                 280                 285             
Thr Trp Gln Arg Asn Gly Leu Ile Leu His Thr Gly Lys Ser Ala Asp
    290                 295                 300                 
Tyr Val Asn Leu Ala Leu Lys Asp Gly Ala Val Ser Leu Val Ile Asn
305                 310                 315                 320 
Leu Gly Ser Gly Ala Phe Glu Ala Ile Val Glu Pro Val Asn Gly Lys
                325                 330                 335     
Phe Asn Asp Asn Ala Trp His Asp Val Lys Val Thr Arg Asn Leu Arg
            340                 345                 350         
Gln Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr
        355                 360                 365             
Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val Gly
    370                 375                 380                 
Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn
385                 390                 395                 400 
Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Ile Arg
                405                 410                 415     
Leu Glu Leu Ser Arg Leu Ala Arg Ile Ala Asp Thr Lys Met Lys Ile
            420                 425                 430         
Tyr Gly Glu Val Val Phe Lys Cys Glu Asn Val Ala Thr Leu Asp Pro
        435                 440                 445             
Ile Asn Phe Glu Thr Pro Glu Ala Tyr Ile Ser Leu Pro Lys Trp Asn
    450                 455                 460                 
Thr Lys Arg Met Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu Pro
465                 470                 475                 480 
Asn Gly Leu Ile Leu Phe Thr His Gly Lys Pro Gln Glu Arg Lys Asp
                485                 490                 495     
Ala Arg Ser Gln Lys Asn Thr Lys Val Asp Phe Phe Ala Val Glu Leu
            500                 505                 510         
Leu Asp Gly Asn Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr Ile
        515                 520                 525             
Lys Val Lys Ala Thr Gln Lys Lys Ala Asn Asp Gly Glu Trp Tyr His
    530                 535                 540                 
Val Asp Ile Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn Ser
545                 550                 555                 560 
Arg Arg Thr Pro Phe Thr Ala Ser Gly Glu Ser Glu Ile Leu Asp Leu
                565                 570                 575     
Glu Gly Asp Met Tyr Leu Gly Gly Leu Pro Glu Asn Arg Ala Gly Leu
            580                 585                 590         
Ile Leu Pro Thr Glu Leu Trp Thr Ala Met Leu Asn Tyr Gly Tyr Val
        595                 600                 605             
Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Arg Ser Lys Asn Ile Arg
    610                 615                 620                 
Gln Leu Ala Glu Met Gln Asn Ala Ala Gly Val Lys Ser Ser Cys Ser
625                 630                 635                 640 
Arg Met Ser Ala Lys Gln Cys Asp Ser Tyr Pro Cys Lys Asn Asn Ala
                645                 650                 655     
Val Cys Lys Asp Gly Trp Asn Arg Phe Ile Cys Asp Cys Thr Gly Thr
            660                 665                 670         
Gly Tyr Trp Gly Arg Thr Cys Glu Arg Glu Ala Ser Ile Leu Ser Tyr
        675                 680                 685             
Asp Gly Ser Met Tyr Met Lys Ile Ile Met Pro Met Val Met His Thr
    690                 695                 700                 
Glu Ala Glu Asp Val Ser Phe Arg Phe Met Ser Gln Arg Ala Tyr Gly
705                 710                 715                 720 
Leu Leu Val Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg Leu
                725                 730                 735     
Glu Leu Asp Gly Gly Arg Val Lys Leu Met Val Asn Leu Asp Cys Ile
            740                 745                 750         
Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr Leu Tyr Ala Gly
        755                 760                 765             
Gln Lys Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg
    770                 775                 780                 
Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Asp Val Ala Glu Gly Thr
785                 790                 795                 800 
Met Val Gly Asp His Thr Arg Leu Glu Phe His Asn Ile Glu Thr Gly
                805                 810                 815     
Ile Met Thr Glu Lys Arg Tyr Ile Ser Val Val Pro Ser Ser Phe Ile
            820                 825                 830         
Gly His Leu Gln Ser Leu Met Phe Asn Gly Leu Leu Tyr Ile Asp Leu
        835                 840                 845             
Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu Lys Ala Arg Phe Gly
    850                 855                 860                 
Leu Arg Asn Ile Ile Ala Asp Pro Val Thr Phe Lys Thr Lys Ser Ser
865                 870                 875                 880 
Tyr Leu Ser Leu Ala Thr Leu Gln Ala Tyr Thr Ser Met His Leu Phe
                885                 890                 895     
Phe Gln Phe Lys Thr Thr Ser Pro Asp Gly Phe Ile Leu Phe Asn Ser
            900                 905                 910         
Gly Asp Gly Asn Asp Phe Ile Ala Val Glu Leu Val Lys Gly Tyr Ile
        915                 920                 925             
His Tyr Val Phe Asp Leu Gly Asn Gly Pro Asn Val Ile Lys Gly Asn
    930                 935                 940                 
Ser Asp Arg Pro Leu Asn Asp Asn Gln Trp His Asn Val Val Ile Thr
945                 950                 955                 960 
Arg Asp Asn Ser Asn Thr His Ser Leu Lys Val Asp Thr Lys Val Val
                965                 970                 975     
Thr Gln Val Ile Asn Gly Ala Lys Asn Leu Asp Leu Lys Gly Asp Leu
            980                 985                 990         
Tyr Met Ala Gly Leu Ala Gln Gly Met Tyr Ser Asn Leu Pro Lys Leu
        995                 1000                1005            
Val Ala Ser Arg Asp Gly Phe Gln Gly Cys Leu Ala Ser Val Asp Leu
    1010                1015                1020                
Asn Gly Arg Leu Pro Asp Leu Ile Asn Asp Ala Leu His Arg Ser Gly
1025                1030                1035                1040
Gln Ile Lys Arg Gly Cys Glu Gly Pro Ser Thr Thr Cys Gln Glu Asp
                1045                1050                1055    
Ser Cys Ala Asn Gln Gly Val Cys Met Gln Gln Trp Glu Gly Phe Thr
            1060                1065                1070        
Cys Asp Cys Ser Met Thr Ser Tyr Ser Gly Asn Gln Cys Asn Asp Pro
        1075                1080                1085            
Gly Ala Thr Tyr Ile Phe Gly Lys Ser Gly Gly Leu Ile Leu Tyr Thr
    1090                1095                1100                
Trp Pro Ala Asn Asp Arg Pro Ser Thr Arg Ser Asp Arg Leu Ala Val
1105                1110                1115                1120
Gly Phe Ser Thr Thr Val Lys Asp Gly Ile Leu Val Arg Ile Asp Ser
                1125                1130                1135    
Ala Pro Gly Leu Gly Asp Phe Leu Gln Leu His Ile Glu Gln Gly Lys
            1140                1145                1150        
Ile Gly Val Val Phe Asn Ile Gly Thr Val Asp Ile Ser Ile Lys Glu
        1155                1160                1165            
Glu Arg Thr Pro Val Asn Asp Gly Lys Tyr His Val Val Arg Phe Thr
    1170                1175                1180                
Arg Asn Gly Gly Asn Ala Thr Leu Gln Val Asp Asn Trp Pro Val Asn
1185                1190                1195                1200
Glu His Tyr Pro Thr Gly Arg Gln Leu Thr Ile Phe Asn Thr Gln Ala
                1205                1210                1215    
Gln Ile Ala Ile Gly Gly Lys Asp Lys Gly Arg Leu Phe Gln Gly Gln
            1220                1225                1230        
Leu Ser Gly Leu Tyr Tyr Asp Gly Leu Lys Val Leu Asn Met Ala Ala
        1235                1240                1245            
Glu Asn Asn Pro Asn Ile Lys Ile Asn Gly Ser Val Arg Leu Val Gly
    1250                1255                1260                
Glu Val Pro Ser Ile Leu Gly Thr Thr Gln Thr Thr Ser Met Pro Pro
1265                1270                1275                1280
Glu Met Ser Thr Thr Val Met Glu Thr Thr Thr Thr Met Ala Thr Thr
                1285                1290                1295    
Thr Thr Arg Lys Asn Arg Ser Thr Ala Ser Ile Gln Pro Thr Ser Asp
            1300                1305                1310        
Asp Leu Val Ser Ser Ala Glu Cys Ser Ser Asp Asp Glu Asp Phe Val
        1315                1320                1325            
Glu Cys Glu Pro Ser Thr Asp Lys Ser Leu Ser Thr Ser Ile Phe Glu
    1330                1335                1340                
Gly Gly Tyr Lys Ala His Ala Pro Lys Trp Glu Ser Lys Asp Phe Arg
1345                1350                1355                1360
Pro Asn Lys Val Ser Glu Thr Ser Arg Thr Thr Thr Thr Ser Leu Ser
                1365                1370                1375    
Pro Glu Leu Ile Arg Phe Thr Ala Ser Ser Ser Ser Gly Met Val Pro
            1380                1385                1390        
Lys Leu Pro Ala Gly Lys Met Asn Asn Arg Asp Leu Lys Pro Gln Pro
        1395                1400                1405            
Asp Ile Val Leu Leu Pro Leu Pro Thr Ala Tyr Glu Leu Asp Ser Thr
    1410                1415                1420                
Lys Leu Lys Ser Pro Leu Ile Thr Ser Pro Met Phe Arg Asn Val Pro
1425                1430                1435                1440
Thr Ala Asn Pro Thr Glu Pro Gly Ile Arg Arg Val Pro Gly Ala Ser
                1445                1450                1455    
Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile
            1460                1465                1470        
Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr
        1475                1480                1485            
Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr Gln Val Asp Glu Thr Arg
    1490                1495                1500                
Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Thr Leu Met Lys Glu
1505                1510                1515                1520
Lys Gln Gln Ser Ser Lys Ser Gly His Lys Lys Gln Lys Asn Lys Asp
                1525                1530                1535    
Arg Glu Tyr Tyr Val
            1540    


<210> 9074
<211> 1392
<212> PRT
<213> Homo sapiens

<400> 9074
Met Ser Ser Thr Leu His Ser Val Phe Phe Thr Leu Lys Val Ser Ile
 1               5                  10                  15      
Leu Leu Gly Ser Leu Leu Gly Leu Cys Leu Gly Leu Glu Phe Met Gly
            20                  25                  30          
Leu Pro Asn Gln Trp Ala Arg Tyr Leu Arg Trp Asp Ala Ser Thr Arg
        35                  40                  45              
Ser Asp Leu Ser Phe Gln Phe Lys Thr Asn Val Ser Thr Gly Leu Leu
    50                  55                  60                  
Leu Tyr Leu Asp Asp Gly Gly Val Cys Asp Phe Leu Cys Leu Ser Leu
65                  70                  75                  80  
Val Asp Gly Arg Val Gln Leu Arg Phe Ser Met Asp Cys Ala Glu Thr
                85                  90                  95      
Ala Val Leu Ser Asn Lys Gln Val Asn Asp Ser Ser Trp His Phe Leu
            100                 105                 110         
Met Val Ser Arg Asp Arg Leu Arg Thr Val Leu Met Leu Asp Gly Glu
        115                 120                 125             
Gly Gln Ser Gly Glu Leu Gln Pro Gln Arg Pro Tyr Met Asp Val Val
    130                 135                 140                 
Ser Asp Leu Phe Leu Gly Gly Val Pro Thr Asp Ile Arg Pro Ser Ala
145                 150                 155                 160 
Leu Thr Leu Asp Gly Val Gln Ala Met Pro Gly Phe Lys Gly Leu Ile
                165                 170                 175     
Leu Asp Leu Lys Tyr Gly Asn Ser Glu Pro Arg Leu Leu Gly Ser Arg
            180                 185                 190         
Gly Val Gln Met Asp Ala Glu Gly Pro Cys Gly Glu Arg Pro Cys Glu
        195                 200                 205             
Asn Gly Gly Ile Cys Phe Leu Leu Asp Gly His Pro Thr Cys Asp Cys
    210                 215                 220                 
Ser Thr Thr Gly Tyr Gly Gly Lys Leu Cys Ser Glu Gly Leu Ser His
225                 230                 235                 240 
Leu Met Met Ser Glu Gln Gly Arg Ser Lys Ala Arg Glu Glu Asn Val
                245                 250                 255     
Ala Thr Phe Arg Gly Ser Glu Tyr Leu Cys Tyr Asp Leu Ser Gln Asn
            260                 265                 270         
Pro Ile Gln Ser Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Trp
        275                 280                 285             
Gln Arg Asn Gly Leu Ile Leu His Thr Gly Lys Ser Ala Asp Tyr Val
    290                 295                 300                 
Asn Leu Ala Leu Lys Asp Gly Ala Val Ser Leu Val Ile Asn Leu Gly
305                 310                 315                 320 
Ser Gly Ala Phe Glu Ala Ile Val Glu Pro Val Asn Gly Lys Phe Asn
                325                 330                 335     
Asp Asn Ala Trp His Asp Val Lys Val Thr Arg Asn Leu Arg Gln Val
            340                 345                 350         
Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu
        355                 360                 365             
Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser
    370                 375                 380                 
Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met
385                 390                 395                 400 
Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Ile Arg Leu Glu
                405                 410                 415     
Leu Ser Arg Leu Ala Arg Ile Ala Asp Thr Lys Met Lys Ile Tyr Gly
            420                 425                 430         
Glu Val Val Phe Lys Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Asn
        435                 440                 445             
Phe Glu Thr Pro Glu Ala Tyr Ile Ser Leu Pro Lys Trp Asn Thr Lys
    450                 455                 460                 
Arg Met Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly
465                 470                 475                 480 
Leu Ile Leu Phe Thr His Gly Lys Pro Gln Glu Arg Lys Asp Ala Arg
                485                 490                 495     
Ser Gln Lys Asn Thr Lys Val Asp Phe Phe Ala Val Glu Leu Leu Asp
            500                 505                 510         
Gly Asn Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Val
        515                 520                 525             
Lys Ala Thr Gln Lys Lys Ala Asn Asp Gly Glu Trp Tyr His Val Asp
    530                 535                 540                 
Ile Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn Ser Arg Arg
545                 550                 555                 560 
Thr Pro Phe Thr Ala Ser Gly Glu Ser Glu Ile Leu Asp Leu Glu Gly
                565                 570                 575     
Asp Met Tyr Leu Gly Gly Leu Pro Glu Asn Arg Ala Gly Leu Ile Leu
            580                 585                 590         
Pro Thr Glu Leu Trp Thr Ala Met Leu Asn Tyr Gly Tyr Val Gly Cys
        595                 600                 605             
Ile Arg Asp Leu Phe Ile Asp Gly Arg Ser Lys Asn Ile Arg Gln Leu
    610                 615                 620                 
Ala Glu Met Gln Asn Ala Ala Gly Val Lys Ser Ser Cys Ser Arg Met
625                 630                 635                 640 
Ser Ala Lys Gln Cys Asp Ser Tyr Pro Cys Lys Asn Asn Ala Val Cys
                645                 650                 655     
Lys Asp Gly Trp Asn Arg Phe Ile Cys Asp Cys Thr Gly Thr Gly Tyr
            660                 665                 670         
Trp Gly Arg Thr Cys Glu Arg Glu Ala Ser Ile Leu Ser Tyr Asp Gly
        675                 680                 685             
Ser Met Tyr Met Lys Ile Ile Met Pro Met Val Met His Thr Glu Ala
    690                 695                 700                 
Glu Asp Val Ser Phe Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu Leu
705                 710                 715                 720 
Val Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu
                725                 730                 735     
Asp Gly Gly Arg Val Lys Leu Met Val Asn Leu Gly Lys Gly Pro Glu
            740                 745                 750         
Thr Leu Tyr Ala Gly Gln Lys Leu Asn Asp Asn Glu Trp His Thr Val
        755                 760                 765             
Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Asp
    770                 775                 780                 
Val Ala Glu Gly Thr Met Val Gly Asp His Thr Arg Leu Glu Phe His
785                 790                 795                 800 
Asn Ile Glu Thr Gly Ile Met Thr Glu Lys Arg Tyr Ile Ser Val Val
                805                 810                 815     
Pro Ser Ser Phe Ile Gly His Leu Gln Ser Leu Met Phe Asn Gly Leu
            820                 825                 830         
Leu Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu
        835                 840                 845             
Lys Ala Arg Phe Gly Leu Arg Asn Ile Ile Ala Asp Pro Val Thr Phe
    850                 855                 860                 
Lys Thr Lys Ser Ser Tyr Leu Ser Leu Ala Thr Leu Gln Ala Tyr Thr
865                 870                 875                 880 
Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr Ser Pro Asp Gly Phe
                885                 890                 895     
Ile Leu Phe Asn Ser Gly Asp Gly Asn Asp Phe Ile Ala Val Glu Leu
            900                 905                 910         
Val Lys Gly Tyr Ile His Tyr Val Phe Asp Leu Gly Asn Gly Pro Asn
        915                 920                 925             
Val Ile Lys Gly Asn Ser Asp Arg Pro Leu Asn Asp Asn Gln Trp His
    930                 935                 940                 
Asn Val Val Ile Thr Arg Asp Asn Ser Asn Thr His Ser Leu Lys Val
945                 950                 955                 960 
Asp Thr Lys Val Val Thr Gln Val Ile Asn Gly Ala Lys Asn Leu Asp
                965                 970                 975     
Leu Lys Gly Asp Leu Tyr Met Ala Gly Leu Ala Gln Gly Met Tyr Ser
            980                 985                 990         
Asn Leu Pro Lys Leu Val Ala Ser Arg Asp Gly Phe Gln Gly Cys Leu
        995                 1000                1005            
Ala Ser Val Asp Leu Asn Gly Arg Leu Pro Asp Leu Ile Asn Asp Ala
    1010                1015                1020                
Leu His Arg Ser Gly Gln Ile Glu Arg Gly Cys Glu Gly Pro Ser Thr
1025                1030                1035                1040
Thr Cys Gln Glu Asp Ser Cys Ala Asn Gln Gly Val Cys Met Gln Gln
                1045                1050                1055    
Trp Glu Gly Phe Thr Cys Asp Cys Ser Met Thr Ser Tyr Ser Gly Asn
            1060                1065                1070        
Gln Cys Asn Asp Pro Gly Ala Thr Tyr Ile Phe Gly Lys Ser Gly Gly
        1075                1080                1085            
Leu Ile Leu Tyr Thr Trp Pro Ala Asn Asp Arg Pro Ser Thr Arg Ser
    1090                1095                1100                
Asp Arg Leu Ala Val Gly Phe Ser Thr Thr Val Lys Asp Gly Ile Leu
1105                1110                1115                1120
Val Arg Ile Asp Ser Ala Pro Gly Leu Gly Asp Phe Leu Gln Leu His
                1125                1130                1135    
Ile Glu Gln Gly Lys Ile Gly Val Val Phe Asn Ile Gly Thr Val Asp
            1140                1145                1150        
Ile Ser Ile Lys Glu Glu Arg Thr Pro Val Asn Asp Gly Lys Tyr His
        1155                1160                1165            
Val Val Arg Phe Thr Arg Asn Gly Gly Asn Ala Thr Leu Gln Val Asp
    1170                1175                1180                
Asn Trp Pro Val Asn Glu His Tyr Pro Thr Gly Asn Thr Asp Asn Glu
1185                1190                1195                1200
Arg Phe Gln Met Val Lys Gln Lys Ile Pro Phe Lys Tyr Asn Arg Pro
                1205                1210                1215    
Val Glu Glu Trp Leu Gln Glu Lys Gly Arg Gln Leu Thr Ile Phe Asn
            1220                1225                1230        
Thr Gln Ala Gln Ile Ala Ile Gly Gly Lys Asp Lys Gly Arg Leu Phe
        1235                1240                1245            
Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asp Gly Leu Lys Val Leu Asn
    1250                1255                1260                
Met Ala Ala Glu Asn Asn Pro Asn Ile Lys Ile Asn Gly Ser Val Arg
1265                1270                1275                1280
Leu Val Gly Glu Val Pro Ser Ile Leu Gly Thr Thr Gln Thr Thr Ser
                1285                1290                1295    
Met Pro Pro Glu Met Ser Thr Thr Val Met Glu Thr Thr Thr Thr Met
            1300                1305                1310        
Ala Thr Thr Thr Thr Arg Lys Asn Arg Ser Thr Ala Ser Ile Gln Pro
        1315                1320                1325            
Thr Ser Asp Asp Leu Val Ser Ser Ala Glu Cys Ser Ser Asp Asp Glu
    1330                1335                1340                
Asp Phe Val Glu Cys Glu Pro Ser Thr Gly Arg Ser Ala Arg Ser Ser
1345                1350                1355                1360
Asn Ala Ala Arg Ser Leu Arg Ala Ala Leu Thr Trp Thr Trp Arg Leu
                1365                1370                1375    
Thr Tyr Thr Phe Thr Pro Ile Ile Phe Ile Ser Cys Val Val His Ser
            1380                1385                1390        


<210> 9075
<211> 688
<212> PRT
<213> Homo sapiens

<400> 9075
Met Lys Pro Leu Ser Leu Leu Ile Glu Ile Leu Ile Ile Leu Gly Val
 1               5                  10                  15      
Thr Ile Lys Thr Ile Lys Ala Glu Glu His Asn Lys Arg Gln Lys Glu
            20                  25                  30          
Arg Asn Val Thr Thr Gln Val Ser Val Asn Glu Ile Lys Gln Tyr Leu
        35                  40                  45              
Ser His Ile Leu Glu Gln Arg Thr Ser Ser Asn Val Ile Asn Lys Arg
    50                  55                  60                  
Glu Asn Leu Leu Glu Lys Lys Lys Asn Gln Arg Lys Ile Arg Ile Lys
65                  70                  75                  80  
Gly Ile Gln Asn Lys Asp Ile Leu Lys Arg Asn Lys Asn His Leu Gln
                85                  90                  95      
Lys Gln Ala Glu Lys Asn Phe Thr Asp Glu Gly Asp Gln Leu Phe Lys
            100                 105                 110         
Met Gly Ile Lys Val Leu Gln Gln Ser Lys Ser Gln Lys Gln Lys Glu
        115                 120                 125             
Glu Ala Tyr Leu Leu Phe Ala Lys Ala Ala Asp Met Gly Asn Leu Lys
    130                 135                 140                 
Ala Met Glu Lys Met Ala Asp Ala Leu Leu Phe Gly Asn Phe Gly Val
145                 150                 155                 160 
Gln Asn Ile Thr Ala Ala Ile Gln Leu Tyr Glu Ser Leu Ala Lys Glu
                165                 170                 175     
Gly Ser Cys Lys Ala Gln Asn Ala Leu Gly Phe Leu Ser Ser Tyr Gly
            180                 185                 190         
Ile Gly Met Glu Tyr Asp Gln Ala Lys Ala Leu Ile Tyr Tyr Thr Phe
        195                 200                 205             
Gly Ser Ala Gly Gly Asn Met Met Ser Gln Met Ile Leu Gly Tyr Arg
    210                 215                 220                 
Tyr Leu Ser Gly Ile Asn Val Leu Gln Asn Cys Glu Val Ala Leu Ser
225                 230                 235                 240 
Tyr Tyr Lys Lys Val Ala Asp Tyr Ile Ala Asp Thr Phe Glu Lys Ser
                245                 250                 255     
Glu Gly Val Pro Val Glu Lys Val Arg Leu Thr Glu Arg Pro Glu Asn
            260                 265                 270         
Leu Ser Ser Asn Ser Glu Ile Leu Asp Trp Asp Ile Tyr Gln Tyr Tyr
        275                 280                 285             
Lys Phe Leu Ala Glu Arg Gly Asp Val Gln Ile Gln Val Ser Leu Gly
    290                 295                 300                 
Gln Leu His Leu Ile Gly Arg Lys Gly Leu Asp Gln Asp Tyr Tyr Lys
305                 310                 315                 320 
Ala Leu His Tyr Phe Leu Lys Ala Ala Lys Ala Gly Ser Ala Asn Ala
                325                 330                 335     
Met Ala Phe Ile Gly Lys Met Tyr Leu Glu Gly Asn Ala Ala Val Pro
            340                 345                 350         
Gln Asn Asn Ala Thr Ala Phe Lys Tyr Phe Ser Met Ala Ala Ser Lys
        355                 360                 365             
Gly Asn Ala Ile Gly Leu His Gly Leu Gly Leu Leu Tyr Phe His Gly
    370                 375                 380                 
Lys Gly Val Pro Leu Asn Tyr Ala Glu Ala Leu Lys Tyr Phe Gln Lys
385                 390                 395                 400 
Ala Ala Glu Lys Gly Trp Pro Asp Ala Gln Phe Gln Leu Gly Phe Met
                405                 410                 415     
Tyr Tyr Ser Gly Ser Gly Ile Trp Lys Asp Tyr Lys Leu Ala Phe Lys
            420                 425                 430         
Tyr Phe Tyr Leu Ala Ser Gln Ser Gly Gln Pro Leu Ala Ile Tyr Tyr
        435                 440                 445             
Leu Ala Lys Met Tyr Ala Thr Gly Thr Gly Val Val Arg Ser Cys Arg
    450                 455                 460                 
Thr Ala Val Glu Leu Tyr Lys Gly Val Cys Glu Leu Gly His Trp Ala
465                 470                 475                 480 
Glu Lys Phe Leu Thr Ala Tyr Phe Ala Tyr Lys Asp Gly Asp Ile Asp
                485                 490                 495     
Ser Ser Leu Val Gln Tyr Ala Leu Leu Ala Glu Met Gly Tyr Glu Val
            500                 505                 510         
Ala Gln Ser Asn Ser Ala Phe Ile Leu Glu Ser Lys Lys Ala Asn Ile
        515                 520                 525             
Leu Glu Lys Glu Lys Met Tyr Pro Met Ala Leu Leu Leu Trp Asn Arg
    530                 535                 540                 
Ala Ala Ile Gln Gly Asn Ala Phe Ala Arg Val Lys Ile Gly Asp Tyr
545                 550                 555                 560 
His Tyr Tyr Gly Tyr Gly Thr Lys Lys Asp Tyr Gln Thr Ala Ala Thr
                565                 570                 575     
His Tyr Ser Ile Ala Ala Asn Lys Tyr His Asn Ala Gln Ala Met Phe
            580                 585                 590         
Asn Leu Ala Tyr Met Tyr Glu His Gly Leu Gly Ile Thr Lys Asp Ile
        595                 600                 605             
His Leu Ala Arg Arg Leu Tyr Asp Met Ala Ala Gln Thr Ser Pro Asp
    610                 615                 620                 
Ala His Ile Pro Val Leu Phe Ala Val Met Lys Leu Glu Thr Thr His
625                 630                 635                 640 
Leu Leu Arg Asp Ile Leu Phe Phe Asn Phe Thr Thr Arg Trp Asn Trp
                645                 650                 655     
Leu Lys Leu Asp Asn Thr Ile Gly Pro His Trp Asp Leu Phe Val Ile
            660                 665                 670         
Gly Leu Ile Val Pro Gly Leu Ile Leu Leu Leu Arg Asn His His Gly
        675                 680                 685             


<210> 9076
<211> 753
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 157, 162, 232, 348
<223> Xaa = Any Amino Acid

<400> 9076
Met Ser Ser Trp Leu Gly Ser Leu Gly Ser Arg Trp Gly Gln Ser Leu
 1               5                  10                  15      
Gly Gln Val Gly Gly Ser Leu Ala Ser Leu Thr Gly Gln Ile Ser Asn
            20                  25                  30          
Phe Thr Lys Val Met Leu Met Glu Gly Ser Glu Glu Val Glu Ala Glu
        35                  40                  45              
Leu Pro Asp Ser Arg Thr Lys Glu Ile Glu Ala Ile His Ser Ile Leu
    50                  55                  60                  
Arg Ser Glu Asn Glu Arg Leu Lys Lys Leu Cys Thr Asp Leu Glu Asp
65                  70                  75                  80  
Gln Leu Leu Lys Leu Arg Ser Ala Ala Gln Ser Val Pro Ser Ala Ala
                85                  90                  95      
Gly Asp Val Pro Ala Thr Thr Ala Ala Ser Phe Ile Tyr Val Ile Ser
            100                 105                 110         
His His Ser Ser Ala Phe His Asp Asp Asp Met Asp Phe Glu Asp Thr
        115                 120                 125             
Ile Leu Ser Gln Gln Glu Ile Asn Arg Leu Leu Asn Glu Val Ser Arg
    130                 135                 140                 
Leu Glu Ser Glu Val Gly Tyr Trp Arg His Ile Ala Xaa Thr Leu Lys
145                 150                 155                 160 
Ala Xaa Gly Thr His Ser Ser Ala Gln Ser Lys Thr Cys Lys Leu Gln
                165                 170                 175     
Asn Ile Ile Lys Glu Leu Lys Gln Asn Gln Ser Gln Glu Ile Asp Asp
            180                 185                 190         
His Gln His Glu Ile Ser Val Leu His Asn Ala His Gln Gln Glu Ile
        195                 200                 205             
Ser Gln Arg His Arg Glu Glu Leu Ser Asp Tyr Glu Glu Arg Thr Glu
    210                 215                 220                 
Glu Leu Lys Asn Leu Leu Gln Xaa Gly Ser Ser Gly Val Thr Glu Ile
225                 230                 235                 240 
Asp His Ser Lys Val Tyr Glu Met Gln Lys Thr Ile Gln Leu Leu Gln
                245                 250                 255     
Thr Glu Lys Val Glu Ser Thr Lys Lys Ile Glu Glu Leu Glu Asp Lys
            260                 265                 270         
Ile Lys Asp Ile Asn Lys Lys Leu Ser Ser Ala Glu Asn Gly Arg Asp
        275                 280                 285             
Ile Leu Arg Arg Glu Gln Glu Gln Leu Asn Val Glu Lys Lys Gln Leu
    290                 295                 300                 
Leu Asn Ala Val Lys Ser Val Gln Gly Arg Gln Leu Tyr Phe Asn Arg
305                 310                 315                 320 
Arg Asp Gln Val Met Leu Ala Leu Lys Gln Lys Gln Met Glu Asn Thr
                325                 330                 335     
Ala Leu Gln Arg Glu Val Gln Cys Leu Arg Asp Xaa Glu Phe Gln Ser
            340                 345                 350         
Asn Gln Lys Leu Glu Arg Leu Arg Asn His Leu Leu Glu Ser Glu Gly
        355                 360                 365             
Ser Tyr Thr Ser Glu Ala Leu Ala Ser Glu His Arg Glu Ala Lys Leu
    370                 375                 380                 
Arg Lys Lys Val Thr Val Leu Glu Glu Lys Leu Val Ser Ser Ser Asn
385                 390                 395                 400 
Ala Met Glu Asn Ala Ser His Gln Ala Ser Val Gln Val Glu Ser Leu
                405                 410                 415     
Gln Glu Gln Leu Asn Val Val Ser Lys Gln Arg Asp Glu Thr Ala Leu
            420                 425                 430         
Leu Ser Ala Ser Gln Gln Gln Val Lys Gln Tyr Ala Leu Ser Leu Ala
        435                 440                 445             
Asn Leu Gln Met Val Leu Gln His Phe Gln Lys Glu Glu Lys Ser Met
    450                 455                 460                 
Tyr Ser Ala Glu Leu Gln Lys Gln Lys Gln Leu Ile Ala Glu Trp Lys
465                 470                 475                 480 
Lys Lys Ala Glu Ser Leu Glu Arg Lys Val Ile Ser Leu Gln Glu Arg
                485                 490                 495     
Leu Asp Glu Ala Asp Ala Ala Leu Asp Ser Ala Ser Arg Leu Thr Glu
            500                 505                 510         
Gln Leu Asp Leu Lys Glu Glu Gln Ile Glu Glu Leu Lys Lys Gln Asn
        515                 520                 525             
Glu Phe Gln Gln Glu Met Leu Asp Asp Val Gln Lys Lys Leu Val Asn
    530                 535                 540                 
Leu Ala Asn Ser Leu Glu Gly Lys Val Asp Lys Val Leu Met Arg Asn
545                 550                 555                 560 
Leu Phe Ile Ser His Phe His Met Pro Lys Asn Gln Arg His Glu Val
                565                 570                 575     
Leu Arg Leu Met Gly Ser Ile Leu Gly Val Arg Arg Glu Glu Met Glu
            580                 585                 590         
Gln Leu Phe His Asp Asn Gln Gly Ser Val Thr Arg Trp Met Thr Gly
        595                 600                 605             
Trp Leu Gly Arg Gly Ser Lys Ser Val Pro Asn Thr Pro Leu Arg Pro
    610                 615                 620                 
Asn Gln Gln Ser Val Leu Asn Ser Ser Phe Ser Glu Cys Phe Val Lys
625                 630                 635                 640 
Phe Leu Glu Thr Glu Ser His Ser Ser Val Pro Pro Pro Lys Leu Ser
                645                 650                 655     
Val His Asp Met Lys Pro Leu Glu Ser Pro Gly Arg Arg Lys Leu Asp
            660                 665                 670         
Thr Asn Ala Pro Glu Ser Phe Lys Asp Thr Ala Glu Ser Arg Ser Gly
        675                 680                 685             
Arg Arg Arg Glu Val Asn Ser Val Leu Ala Pro Arg Ser Ala Ala Val
    690                 695                 700                 
Pro Leu Ile Asn Pro Ala Gly Leu Gly Pro Gly Gly Pro Gln His Leu
705                 710                 715                 720 
Leu Leu Lys Pro Ile Ser Asp Val Trp Pro Thr Phe Thr Pro Leu Pro
                725                 730                 735     
Val Leu Pro Asp Asn Ser Ala Gly Val Val Leu Lys Asp Leu Gly Lys
            740                 745                 750         
Gln
    


<210> 9077
<211> 528
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 472
<223> Xaa = Any Amino Acid

<400> 9077
Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Leu Val Ser Arg
 1               5                  10                  15      
Val Leu Ala Pro His Leu Thr Gly Ala Tyr Ala Lys Asp Val Lys Phe
            20                  25                  30          
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Ile Asp Leu Leu Ala
        35                  40                  45              
Asp Ala Val Ala Leu Thr Met Gly Pro Lys Gly Arg Arg Thr Val Ile
    50                  55                  60                  
Ile Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr
65                  70                  75                  80  
Val Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala
                85                  90                  95      
Lys Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Thr Gly Asp
            100                 105                 110         
Gly Pro Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly
        115                 120                 125             
Ile Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly
    130                 135                 140                 
Val Met Leu Val Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser
145                 150                 155                 160 
Lys Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser
                165                 170                 175     
Ala Asn Gly Asp Lys Glu Ile Gly Asn Ile Ser Asp Ala Met Lys Lys
            180                 185                 190         
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn
        195                 200                 205             
Asp Glu Leu Glu Ile Ile Glu Gly Ile Lys Phe Asp Arg Gly Tyr Ile
    210                 215                 220                 
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln
225                 230                 235                 240 
Asp Ala Tyr Val Leu Leu Ser Glu Lys Arg Lys Pro Leu Val Ile Ile
                245                 250                 255     
Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu Asn Arg
            260                 265                 270         
Leu Lys Val Gly Leu Gln Asp Val Ala Ile Lys Ala Pro Gly Phe Gly
        275                 280                 285             
Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr Gly Gly
    290                 295                 300                 
Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp Val Gln
305                 310                 315                 320 
Pro His Asp Leu Gly Asn Val Gly Glu Val Ile Val Thr Lys Asp Asp
                325                 330                 335     
Ala Thr Leu Leu Lys Glu Lys Gly Asp Lys Ala Gln Ile Glu Lys Arg
            340                 345                 350         
Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu Tyr Glu
        355                 360                 365             
Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Val Val Ala
    370                 375                 380                 
Val Leu Lys Val Glu Gly Phe Val Leu Gly Gly Gly Cys Ala Leu Leu
385                 390                 395                 400 
Arg Cys Ile Leu Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln
                405                 410                 415     
Lys Ile Gly Thr Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met
            420                 425                 430         
Thr Ile Ala Lys Asn Ala Gly Val Glu Gly Ser Ser Ile Val Glu Lys
        435                 440                 445             
Ile Thr Gln Ile Ser Ser Glu Ala Gly Tyr Asp Ala Met Val Gly Asp
    450                 455                 460                 
Phe Val Asn Met Val Glu Lys Xaa Ile Ile Asp Pro Thr Lys Val Val
465                 470                 475                 480 
Arg Thr Ala Leu Leu Asp Ala Ala Gly Val Thr Ser Leu Leu Thr Thr
                485                 490                 495     
Ala Glu Val Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly
            500                 505                 510         
Met Gly Ala Met Gly Arg Met Gly Gly Gly Met Gly Ser Gly Met Phe
        515                 520                 525             


<210> 9078
<211> 294
<212> PRT
<213> Homo sapiens

<400> 9078
Glu Thr Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val
 1               5                  10                  15      
Leu Leu Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys
            20                  25                  30          
Lys Pro Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala
        35                  40                  45              
Glu Val Ser Ala Ser Pro Asp Pro Arg Pro Leu Lys Glu Glu Glu Glu
    50                  55                  60                  
Ala Pro Leu Leu Pro Arg Thr His Leu Gln Ala Glu Pro His Gln His
65                  70                  75                  80  
Gly Cys Trp Thr Val Thr Glu Pro Ala Ala Met Thr Pro Gly Asn Ala
                85                  90                  95      
Thr Pro Pro Arg Thr Pro Glu Val Thr Pro Leu Arg Leu Glu Leu Gln
            100                 105                 110         
Lys Leu Pro Gly Leu Ala Asn Thr Thr Leu Ser Thr Pro Asn Pro Asp
        115                 120                 125             
Thr Gln Ala Ser Ala Ser Pro Asp Pro Arg Pro Leu Arg Glu Glu Glu
    130                 135                 140                 
Glu Ala Arg Leu Leu Pro Arg Thr His Leu Gln Ala Glu Leu His Gln
145                 150                 155                 160 
His Gly Cys Trp Thr Val Thr Glu Pro Ala Ala Leu Thr Pro Gly Asn
                165                 170                 175     
Ala Thr Pro Pro Arg Thr Gln Glu Val Thr Pro Leu Leu Leu Glu Leu
            180                 185                 190         
Gln Lys Leu Pro Glu Leu Val His Ala Thr Leu Ser Thr Pro Asn Pro
        195                 200                 205             
Asp Asn Gln Thr Met Ser Leu Arg Arg Ser Gly Val Pro Gly Leu Pro
    210                 215                 220                 
Ala Val Gly Thr Ala Ala Leu Ala Ser Ser Arg Gly Leu Gly Pro Val
225                 230                 235                 240 
Ala Met Ala Ala Leu Pro Pro Arg Pro Val Pro Val Thr Cys Pro Pro
                245                 250                 255     
Val Leu Ala Leu Arg Thr Arg Thr Pro Trp Ala Ser Pro Val Arg Ser
            260                 265                 270         
Gly Ser Ser Trp Pro Ala Met Leu Arg Thr Cys Met Ile Lys Met Trp
        275                 280                 285             
Thr Ala Val Arg Ser Gly
    290                 


<210> 9079
<211> 658
<212> PRT
<213> Homo sapiens

<400> 9079
Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu
 1               5                  10                  15      
Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro
            20                  25                  30          
Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Val
        35                  40                  45              
Ser Gly Gly Gly Thr Gly Leu Arg Ser Ala Leu Ser Val Pro Pro Pro
    50                  55                  60                  
Gln Pro Ala Gly Ser Ser Arg Ala Gly Ser Gly Thr Gly Thr His Thr
65                  70                  75                  80  
Gly Ser Asp Pro Pro Met Glu Arg Gly Ala Gly Ala Gly Arg Lys Leu
                85                  90                  95      
Pro Asp Thr Gly Arg Cys Pro Val Thr Glu Gly Ser Thr Val Gln Leu
            100                 105                 110         
Ile Ala Pro Trp Asn Ala Ala Asp Val His Ser His Gly Asp Lys Asp
        115                 120                 125             
Ser Gln Thr Cys Ile Arg Val Ser Ala Ser Pro Asp Pro Arg Pro Leu
    130                 135                 140                 
Lys Glu Glu Glu Glu Ala Pro Leu Leu Pro Arg Thr His Leu Gln Ala
145                 150                 155                 160 
Glu Pro His Gln His Gly Cys Trp Thr Val Thr Glu Pro Ala Ala Met
                165                 170                 175     
Thr Pro Gly Asn Ala Thr Pro Pro Arg Thr Pro Glu Val Thr Pro Leu
            180                 185                 190         
Arg Leu Glu Leu Gln Lys Leu Pro Gly Leu Ala Asn Thr Thr Leu Ser
        195                 200                 205             
Thr Pro Asn Pro Asp Thr Gln Ala Ser Ala Ser Pro Asp Pro Arg Pro
    210                 215                 220                 
Leu Arg Glu Glu Glu Glu Ala Arg Leu Leu Pro Arg Thr His Leu Gln
225                 230                 235                 240 
Ala Glu Leu His Gln His Gly Cys Trp Thr Val Thr Glu Pro Ala Ala
                245                 250                 255     
Leu Thr Pro Gly Asn Ala Thr Pro Pro Arg Thr Gln Glu Val Thr Pro
            260                 265                 270         
Leu Leu Leu Glu Leu Gln Lys Leu Pro Glu Leu Val His Ala Thr Leu
        275                 280                 285             
Ser Thr Pro Asn Pro Asp Asn Gln Val Thr Ile Lys Val Val Glu Asp
    290                 295                 300                 
Pro Gln Ala Glu Val Ser Ile Asp Leu Leu Ala Glu Pro Ser Asn Pro
305                 310                 315                 320 
Pro Pro Gln Asp Thr Leu Ser Trp Leu Pro Ala Leu Trp Ser Phe Leu
                325                 330                 335     
Trp Gly Asp Tyr Lys Gly Glu Glu Lys Asp Arg Ala Pro Gly Glu Lys
            340                 345                 350         
Gly Glu Glu Lys Glu Glu Asp Glu Asp Tyr Pro Ser Glu Asp Ile Glu
        355                 360                 365             
Gly Glu Asp Gln Glu Asp Lys Glu Glu Asp Glu Glu Glu Gln Ala Leu
    370                 375                 380                 
Trp Phe Asn Gly Thr Thr Asp Asn Trp Asp Gln Gly Trp Leu Ala Pro
385                 390                 395                 400 
Gly Asp Trp Val Phe Lys Asp Ser Val Ser Tyr Asp Tyr Glu Pro Gln
                405                 410                 415     
Lys Glu Trp Ser Pro Trp Ser Pro Cys Ser Gly Asn Cys Ser Thr Gly
            420                 425                 430         
Lys Gln Gln Arg Thr Arg Pro Cys Gly Tyr Gly Cys Thr Ala Thr Glu
        435                 440                 445             
Thr Arg Thr Cys Asp Leu Pro Ser Cys Pro Gly Thr Glu Asp Lys Asp
    450                 455                 460                 
Thr Leu Gly Leu Pro Ser Glu Glu Trp Lys Leu Leu Ala Arg Asn Ala
465                 470                 475                 480 
Thr Asp Met His Asp Gln Asp Val Asp Ser Cys Glu Lys Trp Leu Asn
                485                 490                 495     
Cys Lys Ser Asp Phe Leu Ile Lys Tyr Leu Ser Gln Met Leu Arg Asp
            500                 505                 510         
Leu Pro Ser Cys Pro Cys Ala Tyr Pro Leu Glu Ala Met Asp Ser Pro
        515                 520                 525             
Val Ser Leu Gln Asp Glu His Gln Gly Arg Ser Phe Arg Trp Arg Asp
    530                 535                 540                 
Ala Ser Gly Pro Arg Glu Arg Leu Asp Ile Tyr Gln Pro Thr Ala Arg
545                 550                 555                 560 
Phe Cys Leu Arg Ser Met Leu Ser Gly Glu Ser Ser Thr Leu Ala Ala
                565                 570                 575     
Gln His Cys Cys Tyr Asp Glu Asp Ser Arg Leu Leu Thr Arg Gly Lys
            580                 585                 590         
Gly Ala Gly Met Pro Asn Leu Ile Ser Thr Asp Phe Ser Pro Lys Leu
        595                 600                 605             
His Phe Lys Phe Asp Thr Thr Pro Trp Ile Leu Cys Lys Gly Asp Trp
    610                 615                 620                 
Ser Arg Leu His Ala Val Leu Pro Pro Asn Asn Gly Arg Ala Cys Thr
625                 630                 635                 640 
Asp Asn Pro Leu Glu Glu Glu Tyr Leu Ala Gln Leu Gln Glu Ala Lys
                645                 650                 655     
Glu Tyr
        


<210> 9080
<211> 468
<212> PRT
<213> Homo sapiens

<400> 9080
Met Gly Phe Leu Gly Thr Gly Thr Trp Ile Leu Val Leu Val Leu Pro
 1               5                  10                  15      
Ile Gln Ala Phe Pro Lys Pro Gly Gly Ser Gln Asp Lys Ser Leu His
            20                  25                  30          
Asn Arg Glu Leu Ser Ala Glu Arg Pro Leu Asn Glu Gln Ile Ala Glu
        35                  40                  45              
Ala Glu Glu Asp Lys Ile Lys Lys Thr Tyr Pro Pro Glu Asn Lys Pro
    50                  55                  60                  
Gly Gln Ser Asn Tyr Ser Phe Val Asp Asn Leu Asn Leu Leu Lys Ala
65                  70                  75                  80  
Ile Thr Glu Lys Glu Lys Ile Glu Lys Glu Arg Gln Ser Ile Arg Ser
                85                  90                  95      
Ser Pro Leu Asp Asn Lys Leu Asn Val Glu Asp Val Asp Ser Thr Lys
            100                 105                 110         
Asn Arg Lys Leu Ile Asp Asp Tyr Asp Ser Thr Lys Ser Gly Leu Asp
        115                 120                 125             
His Lys Phe Gln Asp Asp Pro Asp Gly Leu His Gln Leu Asp Gly Thr
    130                 135                 140                 
Pro Leu Thr Ala Glu Asp Ile Val His Lys Ile Ala Ala Arg Ile Tyr
145                 150                 155                 160 
Glu Glu Asn Asp Arg Ala Ala Phe Asp Lys Ile Val Ser Lys Leu Leu
                165                 170                 175     
Asn Leu Gly Leu Ile Thr Glu Ser Gln Ala His Thr Leu Glu Asp Glu
            180                 185                 190         
Val Ala Glu Val Leu Gln Lys Leu Ile Ser Lys Glu Ala Asn Asn Tyr
        195                 200                 205             
Glu Glu Asp Pro Asn Lys Pro Thr Ser Trp Thr Glu Asn Gln Ala Gly
    210                 215                 220                 
Lys Ile Pro Glu Lys Val Thr Pro Met Ala Ala Ile Gln Asp Gly Leu
225                 230                 235                 240 
Ala Lys Gly Glu Asn Asp Glu Thr Val Ser Asn Thr Leu Thr Leu Thr
                245                 250                 255     
Asn Gly Leu Glu Arg Arg Thr Lys Thr Tyr Ser Glu Asp Asn Phe Glu
            260                 265                 270         
Glu Leu Gln Tyr Phe Pro Asn Phe Tyr Ala Leu Leu Lys Ser Ile Asp
        275                 280                 285             
Ser Glu Lys Glu Ala Lys Glu Lys Glu Thr Leu Ile Thr Ile Met Lys
    290                 295                 300                 
Thr Leu Ile Asp Phe Val Lys Met Met Val Lys Tyr Gly Thr Ile Ser
305                 310                 315                 320 
Pro Glu Glu Gly Val Ser Tyr Leu Glu Asn Leu Asp Glu Met Ile Ala
                325                 330                 335     
Leu Gln Thr Lys Asn Lys Leu Glu Lys Asn Ala Thr Asp Asn Ile Ser
            340                 345                 350         
Lys Leu Phe Pro Ala Pro Ser Glu Lys Ser His Glu Glu Thr Asp Ser
        355                 360                 365             
Thr Lys Glu Glu Ala Ala Lys Met Glu Lys Glu Tyr Gly Ser Leu Lys
    370                 375                 380                 
Asp Ser Thr Lys Asp Asp Asn Ser Asn Pro Gly Gly Lys Thr Asp Glu
385                 390                 395                 400 
Pro Lys Gly Lys Thr Glu Ala Tyr Leu Glu Ala Ile Arg Lys Asn Ile
                405                 410                 415     
Glu Trp Leu Lys Lys His Asp Lys Lys Gly Asn Lys Glu Asp Tyr Asp
            420                 425                 430         
Leu Ser Lys Met Arg Asp Phe Ile Asn Lys Gln Ala Asp Ala Tyr Val
        435                 440                 445             
Glu Lys Gly Ile Leu Asp Lys Glu Glu Ala Glu Ala Ile Lys Arg Ile
    450                 455                 460                 
Tyr Ser Ser Leu
465             


<210> 9081
<211> 727
<212> PRT
<213> Homo sapiens

<400> 9081
Val Ser Leu Lys Ser Asp Glu His His Phe Cys Gly Gly Ser Leu Ile
 1               5                  10                  15      
Gln Glu Asp Arg Val Val Thr Ala Ala His Cys Leu Asp Ser Leu Ser
            20                  25                  30          
Glu Lys Gln Leu Lys Asn Ile Thr Val Thr Ser Gly Glu Tyr Ser Leu
        35                  40                  45              
Phe Gln Lys Asp Lys Gln Glu Gln Asn Ile Pro Val Ser Lys Ile Ile
    50                  55                  60                  
Thr His Pro Glu Tyr Asn Ser Arg Glu Tyr Met Ser Pro Asp Ile Ala
65                  70                  75                  80  
Leu Leu Tyr Leu Lys His Lys Val Lys Phe Gly Asn Ala Val Gln Pro
                85                  90                  95      
Ile Cys Leu Pro Asp Ser Asp Asp Lys Val Glu Pro Gly Ile Leu Cys
            100                 105                 110         
Leu Ser Ser Gly Trp Gly Lys Ile Ser Lys Thr Ser Glu Tyr Ser Asn
        115                 120                 125             
Val Leu Gln Glu Met Glu Leu Pro Ile Met Asp Asp Arg Ala Cys Asn
    130                 135                 140                 
Thr Val Leu Lys Ser Met Asn Leu Pro Pro Leu Gly Arg Thr Met Leu
145                 150                 155                 160 
Cys Ala Gly Phe Pro Asp Trp Gly Met Asp Ala Cys Gln Gly Asp Ser
                165                 170                 175     
Gly Gly Pro Leu Val Cys Arg Arg Gly Gly Gly Ile Trp Ile Leu Ala
            180                 185                 190         
Gly Ile Thr Ser Trp Val Ala Gly Cys Ala Gly Gly Ser Val Pro Val
        195                 200                 205             
Arg Asn Asn His Val Lys Ala Ser Leu Gly Ile Phe Ser Lys Val Ser
    210                 215                 220                 
Glu Leu Met Asp Phe Ile Thr Gln Asn Leu Phe Thr Asp Cys Lys Pro
225                 230                 235                 240 
Gln Gly Thr Val Leu Phe Gly Glu Ser Gly Lys Ile Cys Tyr Pro His
                245                 250                 255     
Ser Lys Gly Asp Tyr Tyr Ser His Asn Cys Leu Tyr Val Trp Lys Ile
            260                 265                 270         
Met Val Pro Glu Asp Lys Ile Ile Leu Ile Lys Phe Thr Ser Leu Asp
        275                 280                 285             
Met Glu Lys Gln Val Gly Cys Asp His Asp Tyr Val Ser Leu Arg Ser
    290                 295                 300                 
Ser Ser Gly Val Leu Phe Ser Lys Val Cys Gly Lys Ile Leu Pro Ser
305                 310                 315                 320 
Pro Leu Leu Ala Glu Thr Ser Glu Ala Met Val Pro Phe Val Ser Asp
                325                 330                 335     
Thr Glu Asp Ser Gly Ser Gly Phe Glu Leu Thr Val Thr Ala Val Gln
            340                 345                 350         
Lys Ser Glu Ala Gly Ser Gly Cys Gly Ser Leu Ala Ile Leu Val Glu
        355                 360                 365             
Glu Gly Thr Asn His Ser Ala Lys Tyr Pro Asp Leu Tyr Pro Ser Asn
    370                 375                 380                 
Thr Arg Cys His Trp Phe Ile Cys Ala Pro Glu Lys His Ile Ile Lys
385                 390                 395                 400 
Leu Thr Phe Glu Asp Phe Ala Val Lys Phe Ser Pro Asn Cys Ile Tyr
                405                 410                 415     
Asp Ala Val Val Ile Tyr Gly Asp Ser Glu Glu Lys His Lys Leu Ala
            420                 425                 430         
Lys Leu Cys Gly Met Leu Thr Ile Thr Ser Ile Phe Ser Ser Ser Asn
        435                 440                 445             
Met Thr Val Ile Tyr Phe Lys Ser Asp Gly Lys Asn Arg Leu Gln Gly
    450                 455                 460                 
Phe Lys Ala Arg Phe Thr Ile Leu Pro Ser Asp Val Cys Gly Ile Pro
465                 470                 475                 480 
Pro Phe Ser Pro Gln Trp Leu Ser Arg Arg Ile Ala Gly Gly Glu Glu
                485                 490                 495     
Ala Cys Pro His Cys Trp Pro Trp Gln Val Gly Leu Arg Phe Leu Gly
            500                 505                 510         
Asp Tyr Gln Cys Gly Gly Ala Ile Ile Asn Pro Val Trp Ile Leu Thr
        515                 520                 525             
Ala Ala His Cys Val Gln Leu Lys Asn Asn Pro Leu Ser Trp Thr Ile
    530                 535                 540                 
Ile Ala Gly Asp His Asp Arg Asn Leu Lys Glu Ser Thr Glu Gln Val
545                 550                 555                 560 
Arg Arg Ala Lys His Ile Ile Val His Glu Asp Phe Asn Thr Leu Ser
                565                 570                 575     
Tyr Asp Ser Asp Ile Ala Leu Ile Gln Leu Ser Ser Pro Leu Glu Tyr
            580                 585                 590         
Asn Ser Val Val Arg Pro Val Cys Leu Pro His Ser Ala Glu Pro Leu
        595                 600                 605             
Phe Ser Ser Glu Ile Cys Ala Val Thr Gly Trp Gly Ser Ile Ser Ala
    610                 615                 620                 
Asp Gly Gly Leu Ala Ser Arg Leu Gln Gln Ile Gln Val His Val Leu
625                 630                 635                 640 
Glu Arg Glu Val Cys Glu His Thr Tyr Tyr Ser Ala His Pro Gly Gly
                645                 650                 655     
Ile Thr Glu Lys Met Ile Cys Ala Gly Phe Ala Ala Ser Gly Glu Lys
            660                 665                 670         
Asp Phe Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Arg His Glu
        675                 680                 685             
Asn Gly Pro Phe Val Leu Tyr Gly Ile Val Ser Trp Gly Ala Gly Cys
    690                 695                 700                 
Val Gln Pro Trp Lys Pro Gly Val Phe Ala Arg Val Met Ile Phe Leu
705                 710                 715                 720 
Asp Trp Ile Gln Ser Lys Ile
                725         


<210> 9082
<211> 1134
<212> PRT
<213> Homo sapiens

<400> 9082
Met Gly Leu Leu Ala Ser Ala Gly Leu Leu Leu Leu Leu Val Ile Gly
 1               5                  10                  15      
His Pro Arg Ser Leu Gly Leu Lys Cys Gly Ile Arg Met Val Asn Met
            20                  25                  30          
Lys Ser Lys Glu Pro Ala Val Gly Ser Arg Phe Phe Ser Arg Ile Ser
        35                  40                  45              
Ser Trp Arg Asn Ser Thr Val Thr Gly His Pro Trp Gln Val Ser Leu
    50                  55                  60                  
Lys Ser Asp Glu His His Phe Cys Gly Gly Ser Leu Ile Gln Glu Asp
65                  70                  75                  80  
Arg Val Val Thr Ala Ala His Cys Leu Asp Ser Leu Ser Glu Lys Gln
                85                  90                  95      
Leu Lys Asn Ile Thr Val Thr Ser Gly Glu Tyr Ser Leu Phe Gln Lys
            100                 105                 110         
Asp Lys Gln Glu Gln Asn Ile Pro Val Ser Lys Ile Ile Thr His Pro
        115                 120                 125             
Glu Tyr Asn Ser Arg Glu Tyr Met Ser Pro Asp Ile Ala Leu Leu Tyr
    130                 135                 140                 
Leu Lys His Lys Val Lys Phe Gly Asn Ala Val Gln Pro Ile Cys Leu
145                 150                 155                 160 
Pro Asp Ser Asp Asp Lys Val Glu Pro Gly Ile Leu Cys Leu Ser Ser
                165                 170                 175     
Gly Trp Gly Lys Ile Ser Lys Thr Ser Glu Tyr Ser Asn Val Leu Gln
            180                 185                 190         
Glu Met Glu Leu Pro Ile Met Asp Asp Arg Ala Cys Asn Thr Val Leu
        195                 200                 205             
Lys Ser Met Asn Leu Pro Pro Leu Gly Arg Thr Met Leu Cys Ala Gly
    210                 215                 220                 
Phe Pro Asp Trp Gly Met Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro
225                 230                 235                 240 
Leu Val Cys Arg Arg Gly Gly Gly Ile Trp Ile Leu Ala Gly Ile Thr
                245                 250                 255     
Ser Trp Val Ala Gly Cys Ala Gly Gly Ser Val Pro Val Arg Asn Asn
            260                 265                 270         
His Val Lys Ala Ser Leu Gly Ile Phe Ser Lys Val Ser Glu Leu Met
        275                 280                 285             
Asp Phe Ile Thr Gln Asn Leu Phe Thr Gly Leu Asp Arg Gly Gln Pro
    290                 295                 300                 
Leu Ser Lys Val Gly Ser Arg Tyr Ile Thr Lys Ala Leu Ser Ser Val
305                 310                 315                 320 
Gln Glu Val Asn Gly Ser Gln Arg Gly Lys Gly Ile Leu Asp Met Glu
                325                 330                 335     
Lys Gln Val Gly Cys Asp His Asp Tyr Val Ser Leu Arg Ser Ser Ser
            340                 345                 350         
Gly Val Leu Phe Asn Gln Arg Ser Leu Met Glu Asp Asp Gly Lys Gln
        355                 360                 365             
Asn Lys Arg Val Cys Gly Lys Ile Leu Pro Ser Pro Leu Leu Ala Glu
    370                 375                 380                 
Thr Ser Glu Ala Met Val Pro Phe Val Ser Asp Thr Glu Asp Ser Gly
385                 390                 395                 400 
Ser Gly Phe Glu Leu Thr Val Thr Ala Val Gln Lys Ser Glu Ala Gly
                405                 410                 415     
Ser Gly Cys Gly Ser Leu Ala Ile Leu Val Glu Glu Gly Thr Asn His
            420                 425                 430         
Ser Ala Lys Tyr Pro Asp Leu Tyr Pro Ser Asn Thr Arg Cys His Trp
        435                 440                 445             
Phe Ile Cys Ala Pro Glu Lys His Ile Ile Lys Leu Thr Phe Glu Asp
    450                 455                 460                 
Phe Ala Val Lys Phe Ser Pro Asn Cys Ile Tyr Asp Ala Val Val Ile
465                 470                 475                 480 
Tyr Gly Asp Ser Glu Glu Lys His Lys Leu Ala Lys Leu Cys Gly Met
                485                 490                 495     
Leu Thr Ile Thr Ser Ile Phe Ser Ser Ser Asn Met Thr Val Ile Tyr
            500                 505                 510         
Phe Lys Ser Asp Gly Lys Asn Arg Leu Gln Gly Phe Lys Ala Arg Phe
        515                 520                 525             
Thr Ile Leu Pro Ser Glu Ser Leu Asn Lys Phe Glu Pro Lys Leu Pro
    530                 535                 540                 
Pro Gln Asn Asn Pro Val Ser Thr Val Lys Ala Ile Leu His Asp Val
545                 550                 555                 560 
Cys Gly Ile Pro Pro Phe Ser Pro Gln Trp Leu Ser Arg Arg Ile Ala
                565                 570                 575     
Gly Gly Glu Glu Ala Cys Pro His Cys Trp Pro Trp Gln Val Gly Leu
            580                 585                 590         
Arg Phe Leu Gly Asp Tyr Gln Cys Gly Gly Ala Ile Ile Asn Pro Val
        595                 600                 605             
Trp Ile Leu Thr Ala Ala His Cys Val Gln Leu Lys Asn Asn Pro Leu
    610                 615                 620                 
Ser Trp Thr Ile Ile Ala Gly Asp His Asp Arg Asn Leu Lys Glu Ser
625                 630                 635                 640 
Thr Glu Gln Val Arg Arg Ala Lys His Ile Ile Val His Glu Asp Phe
                645                 650                 655     
Asn Thr Leu Ser Tyr Asp Ser Asp Ile Ala Leu Ile Gln Leu Ser Ser
            660                 665                 670         
Pro Leu Glu Tyr Asn Ser Val Val Arg Pro Val Cys Leu Pro His Ser
        675                 680                 685             
Ala Glu Pro Leu Phe Ser Ser Glu Ile Cys Ala Val Thr Gly Trp Gly
    690                 695                 700                 
Ser Ile Ser Ala Asp Gly Gly Leu Ala Ser Arg Leu Gln Gln Ile Gln
705                 710                 715                 720 
Val His Val Leu Glu Arg Glu Val Cys Glu His Thr Tyr Tyr Ser Ala
                725                 730                 735     
His Pro Gly Gly Ile Thr Glu Lys Met Ile Cys Ala Gly Phe Ala Ala
            740                 745                 750         
Ser Gly Glu Lys Asp Phe Cys Gln Gly Asp Ser Gly Gly Pro Leu Val
        755                 760                 765             
Cys Arg His Glu Asn Gly Pro Phe Val Leu Tyr Gly Ile Val Ser Trp
    770                 775                 780                 
Gly Ala Gly Cys Val Gln Pro Trp Lys Pro Gly Val Phe Ala Arg Val
785                 790                 795                 800 
Met Ile Phe Leu Asp Trp Ile Gln Ser Lys Ile Asn Gly Pro Ala Ser
                805                 810                 815     
Leu Gln Thr Asn Asn Lys Cys Lys Thr Leu Lys Gln Gln Leu Pro Pro
            820                 825                 830         
Pro Thr Pro Ser Pro Asp Ser Ala Ser Trp Pro Gly Cys Cys Ser Glu
        835                 840                 845             
Ala Glu Leu Glu Lys Pro Arg Gly Phe Phe Pro Thr Pro Arg Tyr Leu
    850                 855                 860                 
Leu Asp Tyr Arg Gly Arg Leu Glu Cys Ser Trp Val Leu Arg Val Ser
865                 870                 875                 880 
Ala Ser Ser Met Ala Lys Phe Thr Ile Glu Tyr Leu Ser Leu Leu Gly
                885                 890                 895     
Ser Pro Val Cys Gln Asp Ser Val Leu Ile Ile Tyr Glu Glu Arg His
            900                 905                 910         
Ser Lys Arg Lys Thr Ala Gly Gly Leu His Gly Arg Arg Leu Tyr Ser
        915                 920                 925             
Met Thr Phe Met Ser Pro Gly Pro Leu Val Arg Val Thr Phe His Ala
    930                 935                 940                 
Leu Val Arg Gly Ala Phe Gly Ile Ser Tyr Ile Asp Leu Lys Val Leu
945                 950                 955                 960 
Gly Pro Lys Asp Ser Lys Ile Thr Arg Leu Ser Gln Ser Ser Asn Arg
                965                 970                 975     
Glu His Leu Val Pro Cys Glu Asp Val Leu Leu Thr Lys Pro Glu Gly
            980                 985                 990         
Ile Met Gln Ile Pro Arg Asn Ser His Arg Thr Thr Met Gly Cys Gln
        995                 1000                1005            
Trp Arg Leu Val Ala Pro Leu Asn His Ile Ile Gln Leu Asn Ile Ile
    1010                1015                1020                
Asn Phe Pro Met Lys Pro Thr Thr Phe Val Cys His Gly His Leu Arg
1025                1030                1035                1040
Val Tyr Glu Gly Phe Gly Pro Gly Lys Lys Leu Ile Ala Ser Phe Ala
                1045                1050                1055    
Gly Thr Leu Ala Met Ile Leu Thr Lys Asp Ile Leu Lys Arg Glu Lys
            1060                1065                1070        
Leu Asn Phe Ile Asn Thr Tyr Ile Met His Ile Trp Glu Asn Ser Val
        1075                1080                1085            
Tyr Asp Asn Val Arg Ser Val Gly Lys Arg Lys Gln Lys Lys Phe Ala
    1090                1095                1100                
Ser Asn Leu Ser Tyr Ser Met Glu Ala Glu Lys Ser Arg Ile Gln Val
1105                1110                1115                1120
Pro Ala Asp Leu Val Pro Ala Lys Gly Ser Leu Ser Gly Ser
                1125                1130                


<210> 9083
<211> 1180
<212> PRT
<213> Homo sapiens

<400> 9083
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15      
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30          
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45              
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60                  
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80  
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95      
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110         
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125             
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140                 
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160 
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175     
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190         
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205             
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220                 
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240 
Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly
                245                 250                 255     
Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu
            260                 265                 270         
Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu
        275                 280                 285             
Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys
    290                 295                 300                 
Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln
305                 310                 315                 320 
Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val
                325                 330                 335     
Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val
            340                 345                 350         
Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn
        355                 360                 365             
Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile
    370                 375                 380                 
Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe
385                 390                 395                 400 
Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser
                405                 410                 415     
Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala
            420                 425                 430         
Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile
        435                 440                 445             
Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu
    450                 455                 460                 
Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu
465                 470                 475                 480 
Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala
                485                 490                 495     
Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu
            500                 505                 510         
Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp
        515                 520                 525             
Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val
    530                 535                 540                 
Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val
545                 550                 555                 560 
Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr
                565                 570                 575     
Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser
            580                 585                 590         
Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala
        595                 600                 605             
Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val
    610                 615                 620                 
Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu
625                 630                 635                 640 
Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser
                645                 650                 655     
Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro
            660                 665                 670         
Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala
        675                 680                 685             
Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala
    690                 695                 700                 
Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr
705                 710                 715                 720 
Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly
                725                 730                 735     
Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn
            740                 745                 750         
Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg
        755                 760                 765             
Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val
    770                 775                 780                 
Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile
785                 790                 795                 800 
Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val
                805                 810                 815     
Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn
            820                 825                 830         
Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp
        835                 840                 845             
Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile
    850                 855                 860                 
Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile
865                 870                 875                 880 
Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu
                885                 890                 895     
Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val
            900                 905                 910         
Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr
        915                 920                 925             
Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro
    930                 935                 940                 
Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn
945                 950                 955                 960 
Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr
                965                 970                 975     
His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr
            980                 985                 990         
Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr Lys Phe Tyr
        995                 1000                1005            
Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile Thr Glu Glu
    1010                1015                1020                
Ala Val Thr Thr Val Asp Glu Ala Met Ala Ser Arg Gln Val Asp Ile
1025                1030                1035                1040
Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu
                1045                1050                1055    
Ile Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly
            1060                1065                1070        
Lys Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile
        1075                1080                1085            
Gln Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala
    1090                1095                1100                
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg
1105                1110                1115                1120
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu
                1125                1130                1135    
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr
            1140                1145                1150        
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu
        1155                1160                1165            
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
    1170                1175                1180


<210> 9084
<211> 1183
<212> PRT
<213> Homo sapiens

<400> 9084
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15      
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30          
Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys
        35                  40                  45              
Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala
    50                  55                  60                  
Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His
65                  70                  75                  80  
Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly
                85                  90                  95      
Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr Glu
            100                 105                 110         
Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val Ser
        115                 120                 125             
Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys Glu
    130                 135                 140                 
Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu Pro
145                 150                 155                 160 
Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met Asp
                165                 170                 175     
Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly Leu
            180                 185                 190         
Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg Glu
        195                 200                 205             
Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln Gln
    210                 215                 220                 
Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn Asp
225                 230                 235                 240 
Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys Ser
                245                 250                 255     
Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala Ser
            260                 265                 270         
Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile Ala
        275                 280                 285             
Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly Met
    290                 295                 300                 
Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu Gln
305                 310                 315                 320 
Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile Ala
                325                 330                 335     
Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val Lys
            340                 345                 350         
Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser Pro
        355                 360                 365             
Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys Pro
    370                 375                 380                 
Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro Asp
385                 390                 395                 400 
Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn Val
                405                 410                 415     
Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu Tyr
            420                 425                 430         
Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro Pro
        435                 440                 445             
Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn Arg
    450                 455                 460                 
Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr Ile
465                 470                 475                 480 
Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile Tyr
                485                 490                 495     
Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala Gln Lys Asp
            500                 505                 510         
Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala
        515                 520                 525             
Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp Ile Val Lys
    530                 535                 540                 
Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe Glu
545                 550                 555                 560 
Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp Leu
                565                 570                 575     
Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp Lys
            580                 585                 590         
Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr Tyr
        595                 600                 605             
Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala Val
    610                 615                 620                 
Leu Ser Val Val Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr
625                 630                 635                 640 
Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp
                645                 650                 655     
Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met
            660                 665                 670         
His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln
        675                 680                 685             
Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg
    690                 695                 700                 
Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser
705                 710                 715                 720 
Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala
                725                 730                 735     
Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys
            740                 745                 750         
Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val
        755                 760                 765             
Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val
    770                 775                 780                 
Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro
785                 790                 795                 800 
Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu
                805                 810                 815     
Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala
            820                 825                 830         
Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val
        835                 840                 845             
His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly
    850                 855                 860                 
Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg
865                 870                 875                 880 
Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His
                885                 890                 895     
Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val
            900                 905                 910         
Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val
        915                 920                 925             
Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile
    930                 935                 940                 
Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser
945                 950                 955                 960 
His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile
                965                 970                 975     
Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala
            980                 985                 990         
Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr
        995                 1000                1005            
Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile
    1010                1015                1020                
Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Met Ala Ser Arg Gln
1025                1030                1035                1040
Val Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val
                1045                1050                1055    
Ala Leu Leu Ile Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn
            1060                1065                1070        
Lys Gly Gly Lys Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp
        1075                1080                1085            
Pro Glu Ile Gln Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr
    1090                1095                1100                
Ser Asp Ala Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro
1105                1110                1115                1120
Ser Asp Arg Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp
                1125                1130                1135    
Tyr Gly Glu Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile
            1140                1145                1150        
Gly Gln Tyr Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu
        1155                1160                1165            
Ser Ser Glu Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
    1170                1175                1180            


<210> 9085
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 9085
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15      
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30          
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45              
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60                  
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80  
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95      
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110         
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125             
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140                 
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160 
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175     
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190         
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205             
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220                 
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240 
Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu
                245                 250                 255     
Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr
            260                 265                 270         
Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu
        275                 280                 285             
Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp
    290                 295                 300                 
Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn
305                 310                 315                 320 
Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly
                325                 330                 335     
Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr
            340                 345                 350         
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln
        355                 360                 365             
Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala
    370                 375                 380                 
Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro
385                 390                 395                 400 
Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr
                405                 410                 415     
Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys
            420                 425                 430         
Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn
        435                 440                 445             
Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr
    450                 455                 460                 
Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly
465                 470                 475                 480 
Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala
                485                 490                 495     
Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile
            500                 505                 510         
Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg
        515                 520                 525             
Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp
    530                 535                 540                 
Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly
545                 550                 555                 560 
Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser
                565                 570                 575     
Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu
            580                 585                 590         
Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp
        595                 600                 605             
Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser
    610                 615                 620                 
Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro
625                 630                 635                 640 
Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr
                645                 650                 655     
Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp
            660                 665                 670         
Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met
        675                 680                 685             
His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln
    690                 695                 700                 
Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg
705                 710                 715                 720 
Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser
                725                 730                 735     
Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala
            740                 745                 750         
Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys
        755                 760                 765             
Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val
    770                 775                 780                 
Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val
785                 790                 795                 800 
Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro
                805                 810                 815     
Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu
            820                 825                 830         
Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala
        835                 840                 845             
Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val
    850                 855                 860                 
His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly
865                 870                 875                 880 
Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg
                885                 890                 895     
Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His
            900                 905                 910         
Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val
        915                 920                 925             
Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val
    930                 935                 940                 
Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile
945                 950                 955                 960 
Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser
                965                 970                 975     
His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile
            980                 985                 990         
Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala
        995                 1000                1005            
Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr
    1010                1015                1020                
Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile
1025                1030                1035                1040
Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro
                1045                1050                1055    
Asp Val Gly Ala Gly Lys Val Gln Ala Val Asn Thr Arg Ile Ser Asn
            1060                1065                1070        
Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr
        1075                1080                1085            
Glu Gly Pro Glu His Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly
    1090                1095                1100                
Ser Lys Glu Glu Trp Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe
1105                1110                1115                1120
Phe Gly Leu Lys Gly Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val
                1125                1130                1135    
Gly Ala Val Gly Asp Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu
            1140                1145                1150        
Thr Gly Pro Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
        1155                1160                1165            
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
    1170                1175                1180                
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
1185                1190                1195                1200
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
                1205                1210                1215    
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Arg Ser Leu Glu Ser Asp Ala
            1220                1225                1230        
Glu Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg
        1235                1240                1245            
Thr Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu
    1250                1255                1260                
Gly Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr
1265                1270                1275                1280
Ser Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu
                1285                1290                1295    
Ala Pro Ser Pro Val Asn Ala Met Asn Ser Phe Val
            1300                1305            


<210> 9086
<211> 1304
<212> PRT
<213> Homo sapiens

<400> 9086
Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg
 1               5                  10                  15      
Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val
            20                  25                  30          
Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile
        35                  40                  45              
Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile
    50                  55                  60                  
Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp
65                  70                  75                  80  
Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr
                85                  90                  95      
Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly
            100                 105                 110         
Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu
        115                 120                 125             
Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser
    130                 135                 140                 
Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly
145                 150                 155                 160 
Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro
                165                 170                 175     
Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu
            180                 185                 190         
Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu
        195                 200                 205             
Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His
    210                 215                 220                 
Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser
225                 230                 235                 240 
Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu
                245                 250                 255     
Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr
            260                 265                 270         
Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu
        275                 280                 285             
Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp
    290                 295                 300                 
Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn
305                 310                 315                 320 
Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly
                325                 330                 335     
Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr
            340                 345                 350         
Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln
        355                 360                 365             
Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala
    370                 375                 380                 
Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro
385                 390                 395                 400 
Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr
                405                 410                 415     
Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys
            420                 425                 430         
Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn
        435                 440                 445             
Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr
    450                 455                 460                 
Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly
465                 470                 475                 480 
Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala
                485                 490                 495     
Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile
            500                 505                 510         
Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg
        515                 520                 525             
Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp
    530                 535                 540                 
Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly
545                 550                 555                 560 
Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser
                565                 570                 575     
Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu
            580                 585                 590         
Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp
        595                 600                 605             
Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser
    610                 615                 620                 
Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro
625                 630                 635                 640 
Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr
                645                 650                 655     
Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp
            660                 665                 670         
Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met
        675                 680                 685             
His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln
    690                 695                 700                 
Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg
705                 710                 715                 720 
Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser
                725                 730                 735     
Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala
            740                 745                 750         
Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys
        755                 760                 765             
Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val
    770                 775                 780                 
Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val
785                 790                 795                 800 
Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro
                805                 810                 815     
Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu
            820                 825                 830         
Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala
        835                 840                 845             
Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val
    850                 855                 860                 
His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly
865                 870                 875                 880 
Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg
                885                 890                 895     
Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His
            900                 905                 910         
Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val
        915                 920                 925             
Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val
    930                 935                 940                 
Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile
945                 950                 955                 960 
Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser
                965                 970                 975     
His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile
            980                 985                 990         
Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala
        995                 1000                1005            
Asn Lys Thr Arg Trp Thr Leu Lys Asn Leu Asn Phe Ser Thr Arg Tyr
    1010                1015                1020                
Lys Phe Tyr Phe Tyr Ala Gln Thr Ser Ala Gly Ser Gly Ser Gln Ile
1025                1030                1035                1040
Thr Glu Glu Ala Val Thr Thr Val Asp Glu Ala Gly Ile Leu Pro Pro
                1045                1050                1055    
Asp Val Gly Ala Gly Lys Val Gln Ala Val Asn Thr Arg Ile Ser Asn
            1060                1065                1070        
Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala Asn Ile Ser Trp Glu Tyr
        1075                1080                1085            
Glu Gly Pro Glu His Val Asn Phe Tyr Val Glu Tyr Gly Val Ala Gly
    1090                1095                1100                
Ser Lys Glu Glu Trp Arg Lys Glu Ile Val Asn Gly Ser Arg Ser Phe
1105                1110                1115                1120
Phe Gly Leu Lys Gly Leu Met Pro Gly Thr Ala Tyr Lys Val Arg Val
                1125                1130                1135    
Gly Ala Val Gly Asp Ser Gly Phe Val Ser Ser Glu Asp Val Phe Glu
            1140                1145                1150        
Thr Gly Pro Ala Met Ala Ser Arg Gln Val Asp Ile Ala Thr Gln Gly
        1155                1160                1165            
Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile Leu Ile Leu
    1170                1175                1180                
Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys Tyr Pro Val
1185                1190                1195                1200
Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln Pro Met Lys
                1205                1210                1215    
Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala Glu Asp His Lys
            1220                1225                1230        
Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg Thr Val Lys Lys
        1235                1240                1245            
Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Val Asn Gly
    1250                1255                1260                
Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys Lys
1265                1270                1275                1280
Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser Glu Ala Pro Ser Pro
                1285                1290                1295    
Val Asn Ala Met Asn Ser Phe Val
            1300                


<210> 9087
<211> 338
<212> PRT
<213> Homo sapiens

<400> 9087
Met Val Gly Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu
 1               5                  10                  15      
Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val
            20                  25                  30          
Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr
        35                  40                  45              
Ala Ile Leu Arg Cys Val Leu Glu Asp Lys Asn Ser Lys Val Ala Trp
    50                  55                  60                  
Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu
65                  70                  75                  80  
Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu
                85                  90                  95      
Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser
            100                 105                 110         
Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val
        115                 120                 125             
Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn
    130                 135                 140                 
Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu
145                 150                 155                 160 
Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu
                165                 170                 175     
Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser
            180                 185                 190         
Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val
        195                 200                 205             
Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser
    210                 215                 220                 
Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu
225                 230                 235                 240 
Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr
                245                 250                 255     
Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln
            260                 265                 270         
Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr
        275                 280                 285             
Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val
    290                 295                 300                 
Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu
305                 310                 315                 320 
Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser
                325                 330                 335     
Lys Cys
        


<210> 9088
<211> 205
<212> PRT
<213> Homo sapiens

<400> 9088
Met Met Arg Thr Leu Ile Thr Thr His Pro Leu Pro Leu Leu Leu Leu
 1               5                  10                  15      
Pro Gln Gln Leu Leu Gln Leu Val Gln Phe Gln Glu Val Asp Thr Asp
            20                  25                  30          
Phe Asp Phe Pro Glu Glu Asp Lys Lys Glu Glu Phe Glu Glu Cys Leu
        35                  40                  45              
Glu Lys Phe Phe Ser Thr Gly Pro Ala Arg Pro Pro Thr Lys Glu Lys
    50                  55                  60                  
Val Lys Arg Arg Val Leu Ile Glu Pro Gly Met Pro Leu Asn His Ile
65                  70                  75                  80  
Glu Tyr Cys Asn His Glu Ile Met Gly Lys Asn Val Tyr Tyr Lys His
                85                  90                  95      
Arg Trp Val Ala Glu His Tyr Phe Leu Leu Met Gln Tyr Asp Glu Leu
            100                 105                 110         
Gln Lys Ile Cys Tyr Asn Arg Phe Val Pro Cys Lys Asn Gly Ile Arg
        115                 120                 125             
Lys Cys Asn Arg Ser Lys Gly Leu Val Glu Gly Val Tyr Cys Asn Leu
    130                 135                 140                 
Thr Glu Ala Phe Glu Ile Pro Ala Cys Lys Tyr Glu Ser Leu Tyr Arg
145                 150                 155                 160 
Lys Gly Tyr Val Leu Ile Thr Cys Ser Trp Gln Asn Glu Met Gln Lys
                165                 170                 175     
Arg Ile Pro His Thr Ile Asn Asp Leu Val Glu Pro Pro Glu His Arg
            180                 185                 190         
Ser Phe Leu Ser Glu Asp Gly Val Phe Val Ile Ser Pro
        195                 200                 205 


<210> 9089
<211> 139
<212> PRT
<213> Homo sapiens

<400> 9089
Lys Tyr Phe Leu Arg Val Leu Asp Leu Leu Cys Lys Asn Met Lys His
 1               5                  10                  15      
Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp Val Leu Ser
            20                  25                  30          
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
        35                  40                  45              
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
    50                  55                  60                  
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
65                  70                  75                  80  
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
                85                  90                  95      
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
            100                 105                 110         
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
        115                 120                 125             
Arg Asp Thr Val Arg Gly Asp Val Ser Ser Leu
    130                 135                 


<210> 9090
<211> 99
<212> PRT
<213> Homo sapiens

<400> 9090
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg
            


<210> 9091
<211> 665
<212> PRT
<213> Homo sapiens

<400> 9091
Arg Thr Arg Gly Ser Ala Ala Ala Gly Ala Ala Gly Leu Ala Phe Thr
 1               5                  10                  15      
Ala Leu Cys Pro Leu Leu Ala Glu Ala Gln Pro Leu Trp Pro Cys Asp
            20                  25                  30          
Leu Gln Val Leu Arg Asp Pro Gln Leu Arg Arg Gln Val Pro Arg Lys
        35                  40                  45              
Pro Arg Asn Gly Arg Pro Glu Val Trp Ser Val Ser Ser Gln Gly Ser
    50                  55                  60                  
Lys Trp Ile Pro Gly Ala Glu Arg Lys Leu Leu Val Tyr Ser Tyr Phe
65                  70                  75                  80  
Glu Lys Glu Thr Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu
                85                  90                  95      
Glu Glu Trp Glu Cys Leu Asn Pro Ala Gln Gln Asn Leu Tyr Met Asn
            100                 105                 110         
Val Met Leu Glu Asn Tyr Lys Asn Leu Val Phe Leu Ala Gly Ile Ala
        115                 120                 125             
Val Ser Lys Gln Asp Pro Ile Thr Ser Leu Glu Gln Glu Lys Glu Pro
    130                 135                 140                 
Trp Asn Met Lys Ile Cys Glu Met Val Asp Glu Ser Pro Ala Met Cys
145                 150                 155                 160 
Ser Ser Phe Thr Arg Asp Leu Trp Pro Glu Gln Asp Ile Lys Asp Ser
                165                 170                 175     
Phe Gln Gln Val Ile Leu Arg Arg His Gly Lys Cys Glu His Glu Asn
            180                 185                 190         
Leu Gln Leu Arg Lys Gly Ser Ala Asn Val Val Glu Cys Lys Val Tyr
        195                 200                 205             
Lys Lys Gly Tyr Asn Glu Leu Asn Gln Cys Leu Thr Thr Thr Gln Ser
    210                 215                 220                 
Lys Ile Phe Pro Cys Asp Lys Tyr Ile Lys Val Phe His Lys Ile Phe
225                 230                 235                 240 
Asn Ser Asn Arg His Lys Thr Arg His Thr Gly Glu Lys Pro Phe Lys
                245                 250                 255     
Cys Lys Lys Cys Asp Glu Ser Phe Cys Met Leu Leu His Leu His Gln
            260                 265                 270         
His Lys Arg Ile His Ile Arg Glu Asn Ser Tyr Gln Cys Glu Glu Cys
        275                 280                 285             
Asp Lys Val Phe Lys Arg Phe Ser Thr Leu Thr Arg His Lys Arg Val
    290                 295                 300                 
His Thr Gly Glu Lys Pro Phe Lys Cys Glu Glu Cys Gly Lys Ala Phe
305                 310                 315                 320 
Lys His Ser Ser Thr Leu Thr Thr His Lys Met Ile His Thr Gly Glu
                325                 330                 335     
Lys Pro Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Tyr His Ser Ser
            340                 345                 350         
His Leu Thr Thr His Lys Val Ile His Thr Gly Glu Lys Pro Phe Lys
        355                 360                 365             
Cys Glu Glu Cys Gly Lys Ala Phe Asn His Pro Ser Ala Leu Thr Thr
    370                 375                 380                 
His Lys Phe Ile His Val Lys Glu Lys Pro Tyr Lys Cys Glu Glu Cys
385                 390                 395                 400 
Asp Lys Ala Phe Asn Arg Phe Ser Tyr Leu Thr Lys His Lys Ile Ile
                405                 410                 415     
His Ser Gly Glu Lys Ser Tyr Lys Cys Glu Gln Cys Gly Lys Gly Phe
            420                 425                 430         
Asn Trp Ser Ser Thr Leu Thr Lys His Arg Arg Ile His Thr Gly Glu
        435                 440                 445             
Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Val Ser Ser
    450                 455                 460                 
His Leu Thr Thr His Lys Met Ile His Thr Gly Glu Lys Pro Tyr Lys
465                 470                 475                 480 
Cys Glu Glu Cys Gly Lys Ala Phe Asn His Ser Ser Lys Leu Thr Ile
                485                 490                 495     
His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys
            500                 505                 510         
Gly Lys Ala Phe Asn Gln Ser Ser Asn Leu Thr Lys His Lys Ile Ile
        515                 520                 525             
His Thr Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe
    530                 535                 540                 
Asn Arg Ser Ser Asn Leu Thr Thr His Lys Arg Ile His Thr Gly Glu
545                 550                 555                 560 
Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser
                565                 570                 575     
Asn Leu Thr Lys His Asn Ile Ile His Thr Gly Glu Lys Ser Tyr Lys
            580                 585                 590         
Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu Thr Lys
        595                 600                 605             
His Arg Lys Ile Gln Gln Gly Met Val Ala His Ala Cys Asn Pro Asn
    610                 615                 620                 
Thr Leu Arg Gly Leu Gly Glu Gln Ile Ala Arg Ser Gly Val Gln Asp
625                 630                 635                 640 
Gln Pro Gly Gln His Gly Lys Thr Pro Ser Leu Leu Lys Ile Gln Lys
                645                 650                 655     
Phe Ala Gly Cys Gly Gly Arg Arg Leu
            660                 665 


<210> 9092
<211> 142
<212> PRT
<213> Homo sapiens

<400> 9092
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln
            20                  25                  30          
Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu
        35                  40                  45              
Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly
    50                  55                  60                  
Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser
65                  70                  75                  80  
Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr
                85                  90                  95      
Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile
            100                 105                 110         
Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val
        115                 120                 125             
Ile Lys Pro Gly Glu Trp Thr Phe Ala Cys His Leu Tyr Glu
    130                 135                 140         


<210> 9093
<211> 316
<212> PRT
<213> Homo sapiens

<400> 9093
Met Met Arg Thr Cys Val Leu Leu Ser Ala Val Leu Trp Cys Leu Thr
 1               5                  10                  15      
Gly Asp Lys Ile Tyr Val Glu Leu His Gln Asn Ser Pro Val Leu Ile
            20                  25                  30          
Cys Met Asp Phe Lys Leu Ser Lys Lys Glu Ile Val Asp Pro Thr Tyr
        35                  40                  45              
Leu Trp Ile Gly Pro Asn Glu Lys Thr Leu Thr Gly Asn Asn Arg Ile
    50                  55                  60                  
Asn Ile Thr Glu Thr Gly Gln Leu Met Val Lys Asp Phe Leu Glu Pro
65                  70                  75                  80  
Leu Ser Gly Leu Tyr Thr Cys Thr Leu Ser Tyr Lys Thr Val Lys Ala
                85                  90                  95      
Glu Thr Gln Glu Glu Lys Thr Val Lys Lys Arg Tyr Asp Phe Met Val
            100                 105                 110         
Phe Ala Tyr Arg Glu Pro Asp Tyr Ser Tyr Gln Met Ala Val Arg Phe
        115                 120                 125             
Thr Thr Arg Ser Cys Ile Gly Arg Tyr Asn Asp Val Phe Phe Arg Val
    130                 135                 140                 
Leu Lys Lys Ile Leu Asp Ser Leu Ile Ser Asp Leu Ser Cys His Val
145                 150                 155                 160 
Ile Glu Pro Ser Tyr Lys Cys His Ser Val Glu Ile Pro Glu His Gly
                165                 170                 175     
Leu Ile His Glu Leu Phe Ile Ala Phe Gln Val Asn Pro Phe Ala Pro
            180                 185                 190         
Gly Trp Lys Gly Ala Cys Asn Gly Ser Val Asp Cys Glu Asp Thr Thr
        195                 200                 205             
Asn His Asn Ile Leu Gln Ala Arg Asp Arg Ile Glu Asp Phe Phe Arg
    210                 215                 220                 
Ser Gln Ala Tyr Ile Phe Tyr His Asn Phe Asn Lys Thr Leu Pro Ala
225                 230                 235                 240 
Met His Phe Val Asp His Ser Leu Gln Val Val Arg Leu Asp Ser Cys
                245                 250                 255     
Arg Pro Gly Phe Gly Lys Asn Glu Arg Leu His Ser Asn Cys Ala Ser
            260                 265                 270         
Cys Cys Val Val Cys Ser Pro Ala Thr Phe Ser Pro Asp Val Asn Val
        275                 280                 285             
Thr Cys Gln Thr Cys Val Ser Val Leu Thr Tyr Gly Ala Lys Ser Cys
    290                 295                 300                 
Pro Gln Thr Ser Asn Lys Asn Gln Gln Tyr Glu Asp
305                 310                 315     


<210> 9094
<211> 338
<212> PRT
<213> Homo sapiens

<400> 9094
Met Met Arg Thr Cys Val Leu Leu Ser Ala Val Leu Trp Cys Leu Thr
 1               5                  10                  15      
Gly Val Gln Cys Pro Arg Phe Thr Leu Phe Asn Lys Lys Gly Phe Ile
            20                  25                  30          
Tyr Gly Lys Thr Gly Gln Pro Asp Lys Ile Tyr Val Glu Leu His Gln
        35                  40                  45              
Asn Ser Pro Val Leu Ile Cys Met Asp Phe Lys Leu Ser Lys Lys Glu
    50                  55                  60                  
Ile Val Asp Pro Thr Tyr Leu Trp Ile Gly Pro Asn Glu Lys Thr Leu
65                  70                  75                  80  
Thr Gly Asn Asn Arg Ile Asn Ile Thr Glu Thr Gly Gln Leu Met Val
                85                  90                  95      
Lys Asp Phe Leu Glu Pro Leu Ser Gly Leu Tyr Thr Cys Thr Leu Ser
            100                 105                 110         
Tyr Lys Thr Val Lys Ala Glu Thr Gln Glu Glu Lys Thr Val Lys Lys
        115                 120                 125             
Arg Tyr Asp Phe Met Val Phe Ala Tyr Arg Glu Pro Asp Tyr Ser Tyr
    130                 135                 140                 
Gln Met Ala Val Arg Phe Thr Thr Arg Ser Cys Ile Gly Arg Tyr Asn
145                 150                 155                 160 
Asp Val Phe Phe Arg Val Leu Lys Lys Ile Leu Asp Ser Leu Ile Ser
                165                 170                 175     
Asp Leu Ser Cys His Val Ile Glu Pro Ser Tyr Lys Cys His Ser Val
            180                 185                 190         
Glu Ile Pro Glu His Gly Leu Ile His Glu Leu Phe Ile Ala Phe Gln
        195                 200                 205             
Val Asn Pro Phe Ala Pro Gly Trp Lys Gly Ala Cys Asn Gly Ser Val
    210                 215                 220                 
Asp Cys Glu Asp Thr Thr Asn His Asn Ile Leu Gln Ala Arg Asp Arg
225                 230                 235                 240 
Ile Glu Asp Phe Phe Arg Ser Gln Ala Tyr Ile Phe Tyr His Asn Phe
                245                 250                 255     
Asn Lys Thr Leu Pro Ala Met His Phe Val Asp His Ser Leu Gln Val
            260                 265                 270         
Val Arg Leu Asp Ser Cys Arg Pro Gly Phe Gly Lys Asn Glu Arg Leu
        275                 280                 285             
His Ser Asn Cys Ala Ser Cys Cys Val Val Cys Ser Pro Ala Thr Phe
    290                 295                 300                 
Ser Pro Asp Val Asn Val Thr Cys Gln Thr Cys Val Ser Val Leu Thr
305                 310                 315                 320 
Tyr Gly Ala Lys Ser Cys Pro Gln Thr Ser Asn Lys Asn Gln Gln Tyr
                325                 330                 335     
Glu Asp
        


<210> 9095
<211> 564
<212> PRT
<213> Homo sapiens

<400> 9095
Met Leu Ile Ser Arg Asn Lys Leu Ile Leu Leu Leu Gly Ile Val Phe
 1               5                  10                  15      
Phe Glu Arg Gly Lys Ser Ala Thr Leu Ser Leu Pro Lys Ala Pro Ser
            20                  25                  30          
Cys Gly Gln Ser Leu Val Lys Val Gln Pro Trp Asn Tyr Phe Asn Ile
        35                  40                  45              
Phe Ser Arg Ile Leu Gly Gly Ser Gln Val Glu Lys Gly Ser Tyr Pro
    50                  55                  60                  
Trp Gln Val Ser Leu Lys Gln Arg Gln Lys His Ile Cys Gly Gly Ser
65                  70                  75                  80  
Ile Val Ser Pro Gln Trp Val Ile Thr Ala Ala His Cys Ile Ala Asn
                85                  90                  95      
Arg Asn Ile Val Ser Thr Leu Asn Val Thr Ala Gly Glu Tyr Asp Leu
            100                 105                 110         
Ser Gln Thr Asp Pro Gly Glu Gln Thr Leu Thr Ile Glu Thr Val Ile
        115                 120                 125             
Ile His Pro His Phe Ser Thr Lys Lys Pro Met Asp Tyr Asp Ile Ala
    130                 135                 140                 
Leu Leu Lys Met Ala Gly Ala Phe Gln Phe Gly His Phe Val Gly Pro
145                 150                 155                 160 
Ile Cys Leu Pro Glu Leu Arg Glu Gln Phe Glu Ala Gly Phe Ile Cys
                165                 170                 175     
Thr Thr Ala Gly Trp Gly Arg Leu Thr Glu Gly Gly Val Leu Ser Gln
            180                 185                 190         
Val Leu Gln Glu Val Asn Leu Pro Ile Leu Thr Trp Glu Glu Cys Val
        195                 200                 205             
Ala Ala Leu Leu Thr Leu Lys Arg Pro Ile Ser Gly Lys Thr Phe Leu
    210                 215                 220                 
Cys Thr Gly Phe Pro Asp Gly Gly Arg Asp Ala Cys Gln Gly Asp Ser
225                 230                 235                 240 
Gly Gly Ser Leu Met Cys Arg Asn Lys Lys Gly Ala Trp Thr Leu Ala
                245                 250                 255     
Gly Val Thr Ser Trp Gly Leu Gly Cys Gly Arg Gly Trp Arg Asn Asn
            260                 265                 270         
Val Arg Lys Ser Asp Gln Gly Ser Pro Gly Ile Phe Thr Asp Ile Ser
        275                 280                 285             
Lys Val Leu Pro Trp Ile His Glu His Ile Gln Thr Gly Asn Arg Arg
    290                 295                 300                 
Lys Ser Ser Arg Ala Trp Cys Ser Glu Gln Asp Val Ile Val Ser Gly
305                 310                 315                 320 
Ala Glu Gly Lys Leu His Phe Pro Glu Ser Leu His Leu Tyr Tyr Glu
                325                 330                 335     
Ser Lys Gln Arg Cys Val Trp Thr Leu Leu Val Pro Glu Glu Met His
            340                 345                 350         
Val Leu Leu Ser Phe Ser His Leu Asp Val Glu Ser Cys His His Ser
        355                 360                 365             
Tyr Leu Ser Met Tyr Ser Leu Glu Asp Arg Pro Ile Gly Lys Phe Cys
    370                 375                 380                 
Gly Glu Ser Leu Pro Ser Ser Ile Leu Ile Gly Ser Asn Ser Leu Arg
385                 390                 395                 400 
Leu Lys Phe Val Ser Asp Ala Thr Asp Tyr Ala Ala Gly Phe Asn Leu
                405                 410                 415     
Thr Tyr Lys Ala Leu Lys Pro Asn Tyr Ile Pro Asp Ser Gly Cys Ser
            420                 425                 430         
Tyr Leu Thr Val Leu Phe Glu Glu Gly Leu Ile Gln Ser Leu Asn Tyr
        435                 440                 445             
Pro Glu Asn Tyr Ser Asp Lys Ala Asn Cys Asp Trp Ile Phe Gln Ala
    450                 455                 460                 
Ser Lys His His Leu Ile Lys Leu Ser Phe Gln Ser Leu Glu Ile Glu
465                 470                 475                 480 
Glu Ser Gly Asp Cys Thr Ser Asp Tyr Val Thr Val His Ser Asp Val
                485                 490                 495     
Glu Arg Lys Lys Glu Ile Ala Arg Leu Cys Gly Tyr Asp Val Pro Thr
            500                 505                 510         
Pro Val Leu Ser Pro Ser Ser Ile Met Leu Ile Ser Phe Gln Ser Asp
        515                 520                 525             
Glu Asn Gly Thr Cys Arg Gly Phe Gln Ala Thr Val Ser Phe Ile Pro
    530                 535                 540                 
Lys Ala Gly Lys Lys Ile Glu Leu Pro Thr Leu Trp Phe Pro Val Leu
545                 550                 555                 560 
Ile Leu Val Met
                


<210> 9096
<211> 199
<212> PRT
<213> Homo sapiens

<400> 9096
Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys
 1               5                  10                  15      
Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile
            20                  25                  30          
Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val
        35                  40                  45              
Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp
    50                  55                  60                  
Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu
65                  70                  75                  80  
Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu
                85                  90                  95      
Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser
            100                 105                 110         
Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu
        115                 120                 125             
His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro
    130                 135                 140                 
Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu
145                 150                 155                 160 
Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro
                165                 170                 175     
Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser
            180                 185                 190         
Arg Leu Thr Asp Val Thr Leu
        195                 


<210> 9097
<211> 1525
<212> PRT
<213> Homo sapiens

<400> 9097
Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val
 1               5                  10                  15      
Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys
            20                  25                  30          
Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser
        35                  40                  45              
Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly
    50                  55                  60                  
Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His
65                  70                  75                  80  
Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg
                85                  90                  95      
Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg
            100                 105                 110         
Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys
        115                 120                 125             
Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg
    130                 135                 140                 
Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr
145                 150                 155                 160 
Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp
                165                 170                 175     
Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val
            180                 185                 190         
Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser
        195                 200                 205             
Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu
    210                 215                 220                 
Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser
225                 230                 235                 240 
His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val
                245                 250                 255     
Cys Ser Asp Glu Glu Glu Gly His Gln Ser Phe Met Ala Pro Ser Cys
            260                 265                 270         
Ser Val Leu His Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val
        275                 280                 285             
Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu
    290                 295                 300                 
Thr Ile Thr Glu Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro
305                 310                 315                 320 
Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser
                325                 330                 335     
Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg
            340                 345                 350         
Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro
        355                 360                 365             
Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn
    370                 375                 380                 
Ala Asn Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His
385                 390                 395                 400 
Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala
                405                 410                 415     
Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala
            420                 425                 430         
Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr
        435                 440                 445             
Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro
    450                 455                 460                 
Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe
465                 470                 475                 480 
Arg Cys Ser Gly Thr Glu Asp Tyr Arg Ser Lys Leu Ser Gly Asp Cys
                485                 490                 495     
Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys Glu Gly Thr Thr
            500                 505                 510         
Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro Glu His Ile Pro
        515                 520                 525             
Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu Phe Thr Val Leu
    530                 535                 540                 
Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu Arg Lys Ile Asn
545                 550                 555                 560 
Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly Ala Phe Glu Gly
                565                 570                 575     
Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn Arg Leu Glu Asn
            580                 585                 590         
Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu Lys Thr Leu Met
        595                 600                 605             
Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp Ser Phe Ile Gly
    610                 615                 620                 
Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr
625                 630                 635                 640 
Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu Ser Thr Leu Asn
                645                 650                 655     
Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu Ala Trp Leu Gly
            660                 665                 670         
Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn Pro Arg Cys Gln
        675                 680                 685             
Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp Val Ala Ile Gln
    690                 695                 700                 
Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser Cys Ser Pro Leu
705                 710                 715                 720 
Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr Val Val Arg Cys
                725                 730                 735     
Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile Pro Arg Asp Val
            740                 745                 750         
Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu Val Pro Lys Glu
        755                 760                 765             
Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu Ser Asn Asn Arg
    770                 775                 780                 
Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met Thr Gln Leu Leu
785                 790                 795                 800 
Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile Pro Pro Arg Thr
                805                 810                 815     
Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp
            820                 825                 830         
Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu Ser Ala Leu Ser
        835                 840                 845             
His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp Cys Asn Met Gln
    850                 855                 860                 
Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu Pro Gly Ile Ala
865                 870                 875                 880 
Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu Leu Leu Thr Thr
                885                 890                 895     
Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp Val Asn Ile Leu
            900                 905                 910         
Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys Asn Asp Gly Thr
        915                 920                 925             
Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr Cys Pro Tyr Gly
    930                 935                 940                 
Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala Cys Ile Ser Asn
945                 950                 955                 960 
Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu Gly Glu Glu Asp
                965                 970                 975     
Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly Glu Asn Cys Glu
            980                 985                 990         
Val Asn Val Asp Asp Cys Glu Asp Asn Asp Cys Glu Asn Asn Ser Thr
        995                 1000                1005            
Cys Val Asp Gly Ile Asn Asn Tyr Thr Cys Leu Cys Pro Pro Glu Tyr
    1010                1015                1020                
Thr Gly Glu Leu Cys Glu Glu Lys Leu Asp Phe Cys Ala Gln Asp Leu
1025                1030                1035                1040
Asn Pro Cys Gln His Asp Ser Lys Cys Ile Leu Thr Pro Lys Gly Phe
                1045                1050                1055    
Lys Cys Asp Cys Thr Pro Gly Tyr Val Gly Glu His Cys Asp Ile Asp
            1060                1065                1070        
Phe Asp Asp Cys Gln Asp Asn Lys Cys Lys Asn Gly Ala His Cys Thr
        1075                1080                1085            
Asp Ala Val Asn Gly Tyr Thr Cys Ile Cys Pro Glu Gly Tyr Ser Gly
    1090                1095                1100                
Leu Phe Cys Glu Phe Ser Pro Pro Met Val Leu Pro Arg Thr Ser Pro
1105                1110                1115                1120
Cys Asp Asn Phe Asp Cys Gln Asn Gly Ala Gln Cys Ile Val Arg Ile
                1125                1130                1135    
Asn Glu Pro Ile Cys Gln Cys Leu Pro Gly Tyr Gln Gly Glu Lys Cys
            1140                1145                1150        
Glu Lys Leu Val Ser Val Asn Phe Ile Asn Lys Glu Ser Tyr Leu Gln
        1155                1160                1165            
Ile Pro Ser Ala Lys Val Arg Pro Gln Thr Asn Ile Thr Leu Gln Ile
    1170                1175                1180                
Ala Thr Asp Glu Asp Ser Gly Ile Leu Leu Tyr Lys Gly Asp Lys Asp
1185                1190                1195                1200
His Ile Ala Val Glu Leu Tyr Arg Gly Arg Val Arg Ala Ser Tyr Asp
                1205                1210                1215    
Thr Gly Ser His Pro Ala Ser Ala Ile Tyr Ser Val Glu Thr Ile Asn
            1220                1225                1230        
Asp Gly Asn Phe His Ile Val Glu Leu Leu Ala Leu Asp Gln Ser Leu
        1235                1240                1245            
Ser Leu Ser Val Asp Gly Gly Asn Pro Lys Ile Ile Thr Asn Leu Ser
    1250                1255                1260                
Lys Gln Ser Thr Leu Asn Phe Asp Ser Pro Leu Tyr Val Gly Gly Met
1265                1270                1275                1280
Pro Gly Lys Ser Asn Val Ala Ser Leu Arg Gln Ala Pro Gly Gln Asn
                1285                1290                1295    
Gly Thr Ser Phe His Gly Cys Ile Arg Asn Leu Tyr Ile Asn Ser Glu
            1300                1305                1310        
Leu Gln Asp Phe Gln Lys Val Pro Met Gln Thr Gly Ile Leu Pro Gly
        1315                1320                1325            
Cys Glu Pro Cys His Lys Lys Val Cys Ala His Gly Thr Cys Gln Pro
    1330                1335                1340                
Ser Ser Gln Ala Gly Phe Thr Cys Glu Cys Gln Glu Gly Trp Met Gly
1345                1350                1355                1360
Pro Leu Cys Asp Gln Arg Thr Asn Asp Pro Cys Leu Gly Asn Lys Cys
                1365                1370                1375    
Val His Gly Thr Cys Leu Pro Ile Asn Ala Phe Ser Tyr Ser Cys Lys
            1380                1385                1390        
Cys Leu Glu Gly His Gly Gly Val Leu Cys Asp Glu Glu Glu Asp Leu
        1395                1400                1405            
Phe Asn Pro Cys Gln Ala Ile Lys Cys Lys His Gly Lys Cys Arg Leu
    1410                1415                1420                
Ser Gly Leu Gly Gln Pro Tyr Cys Glu Cys Ser Ser Gly Tyr Thr Gly
1425                1430                1435                1440
Asp Ser Cys Asp Arg Glu Ile Ser Cys Arg Gly Glu Arg Ile Arg Asp
                1445                1450                1455    
Tyr Tyr Gln Lys Gln Gln Gly Tyr Ala Ala Cys Gln Thr Thr Lys Lys
            1460                1465                1470        
Val Ser Arg Leu Glu Cys Arg Gly Gly Cys Ala Gly Gly Gln Cys Cys
        1475                1480                1485            
Gly Pro Leu Arg Ser Lys Arg Arg Lys Tyr Ser Phe Glu Cys Thr Asp
    1490                1495                1500                
Gly Ser Ser Phe Val Asp Glu Val Glu Lys Val Val Lys Cys Gly Cys
1505                1510                1515                1520
Thr Arg Cys Val Ser
                1525


<210> 9098
<211> 1529
<212> PRT
<213> Homo sapiens

<400> 9098
Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val
 1               5                  10                  15      
Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys
            20                  25                  30          
Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser
        35                  40                  45              
Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly
    50                  55                  60                  
Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His
65                  70                  75                  80  
Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg
                85                  90                  95      
Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg
            100                 105                 110         
Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys
        115                 120                 125             
Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg
    130                 135                 140                 
Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr
145                 150                 155                 160 
Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp
                165                 170                 175     
Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val
            180                 185                 190         
Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser
        195                 200                 205             
Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu
    210                 215                 220                 
Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser
225                 230                 235                 240 
His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val
                245                 250                 255     
Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His
            260                 265                 270         
Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly
        275                 280                 285             
Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu
    290                 295                 300                 
Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe
305                 310                 315                 320 
Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile
                325                 330                 335     
Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser
            340                 345                 350         
Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe
        355                 360                 365             
Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile
    370                 375                 380                 
Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu
385                 390                 395                 400 
Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe
                405                 410                 415     
Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe
            420                 425                 430         
Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn
        435                 440                 445             
Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala
    450                 455                 460                 
Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Ala
465                 470                 475                 480 
Lys Glu Gln Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Arg Ser Lys Leu
                485                 490                 495     
Ser Gly Asp Cys Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys
            500                 505                 510         
Glu Gly Thr Thr Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro
        515                 520                 525             
Glu His Ile Pro Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu
    530                 535                 540                 
Phe Thr Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu
545                 550                 555                 560 
Arg Lys Ile Asn Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly
                565                 570                 575     
Ala Phe Glu Gly Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn
            580                 585                 590         
Arg Leu Glu Asn Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu
        595                 600                 605             
Lys Thr Leu Met Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp
    610                 615                 620                 
Ser Phe Ile Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn
625                 630                 635                 640 
Gln Ile Thr Thr Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu
                645                 650                 655     
Ser Thr Leu Asn Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu
            660                 665                 670         
Ala Trp Leu Gly Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn
        675                 680                 685             
Pro Arg Cys Gln Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp
    690                 695                 700                 
Val Ala Ile Gln Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser
705                 710                 715                 720 
Cys Ser Pro Leu Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr
                725                 730                 735     
Val Val Arg Cys Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile
            740                 745                 750         
Pro Arg Asp Val Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu
        755                 760                 765             
Val Pro Lys Glu Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu
    770                 775                 780                 
Ser Asn Asn Arg Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met
785                 790                 795                 800 
Thr Gln Leu Leu Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile
                805                 810                 815     
Pro Pro Arg Thr Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu
            820                 825                 830         
His Gly Asn Asp Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu
        835                 840                 845             
Ser Ala Leu Ser His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp
    850                 855                 860                 
Cys Asn Met Gln Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu
865                 870                 875                 880 
Pro Gly Ile Ala Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu
                885                 890                 895     
Leu Leu Thr Thr Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp
            900                 905                 910         
Val Asn Ile Leu Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys
        915                 920                 925             
Asn Asp Gly Thr Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr
    930                 935                 940                 
Cys Pro Tyr Gly Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala
945                 950                 955                 960 
Cys Ile Ser Asn Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu
                965                 970                 975     
Gly Glu Glu Asp Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly
            980                 985                 990         
Glu Asn Cys Glu Val Asn Val Asp Asp Cys Glu Asp Asn Asp Cys Glu
        995                 1000                1005            
Asn Asn Ser Thr Cys Val Asp Gly Ile Asn Asn Tyr Thr Cys Leu Cys
    1010                1015                1020                
Pro Pro Glu Tyr Thr Gly Glu Leu Cys Glu Glu Lys Leu Asp Phe Cys
1025                1030                1035                1040
Ala Gln Asp Leu Asn Pro Cys Gln His Asp Ser Lys Cys Ile Leu Thr
                1045                1050                1055    
Pro Lys Gly Phe Lys Cys Asp Cys Thr Pro Gly Tyr Val Gly Glu His
            1060                1065                1070        
Cys Asp Ile Asp Phe Asp Asp Cys Gln Asp Asn Lys Cys Lys Asn Gly
        1075                1080                1085            
Ala His Cys Thr Asp Ala Val Asn Gly Tyr Thr Cys Ile Cys Pro Glu
    1090                1095                1100                
Gly Tyr Ser Gly Leu Phe Cys Glu Phe Ser Pro Pro Met Val Leu Pro
1105                1110                1115                1120
Arg Thr Ser Pro Cys Asp Asn Phe Asp Cys Gln Asn Gly Ala Gln Cys
                1125                1130                1135    
Ile Val Arg Ile Asn Glu Pro Ile Cys Gln Cys Leu Pro Gly Tyr Gln
            1140                1145                1150        
Gly Glu Lys Cys Glu Lys Leu Val Ser Val Asn Phe Ile Asn Lys Glu
        1155                1160                1165            
Ser Tyr Leu Gln Ile Pro Ser Ala Lys Val Arg Pro Gln Thr Asn Ile
    1170                1175                1180                
Thr Leu Gln Ile Ala Thr Asp Glu Asp Ser Gly Ile Leu Leu Tyr Lys
1185                1190                1195                1200
Gly Asp Lys Asp His Ile Ala Val Glu Leu Tyr Arg Gly Arg Val Arg
                1205                1210                1215    
Ala Ser Tyr Asp Thr Gly Ser His Pro Ala Ser Ala Ile Tyr Ser Val
            1220                1225                1230        
Glu Thr Ile Asn Asp Gly Asn Phe His Ile Val Glu Leu Leu Ala Leu
        1235                1240                1245            
Asp Gln Ser Leu Ser Leu Ser Val Asp Gly Gly Asn Pro Lys Ile Ile
    1250                1255                1260                
Thr Asn Leu Ser Lys Gln Ser Thr Leu Asn Phe Asp Ser Pro Leu Tyr
1265                1270                1275                1280
Val Gly Gly Met Pro Gly Lys Ser Asn Val Ala Ser Leu Arg Gln Ala
                1285                1290                1295    
Pro Gly Gln Asn Gly Thr Ser Phe His Gly Cys Ile Arg Asn Leu Tyr
            1300                1305                1310        
Ile Asn Ser Glu Leu Gln Asp Phe Gln Lys Val Pro Met Gln Thr Gly
        1315                1320                1325            
Ile Leu Pro Gly Cys Glu Pro Cys His Lys Lys Val Cys Ala His Gly
    1330                1335                1340                
Thr Cys Gln Pro Ser Ser Gln Ala Gly Phe Thr Cys Glu Cys Gln Glu
1345                1350                1355                1360
Gly Trp Met Gly Pro Leu Cys Asp Gln Arg Thr Asn Asp Pro Cys Leu
                1365                1370                1375    
Gly Asn Lys Cys Val His Gly Thr Cys Leu Pro Ile Asn Ala Phe Ser
            1380                1385                1390        
Tyr Ser Cys Lys Cys Leu Glu Gly His Gly Gly Val Leu Cys Asp Glu
        1395                1400                1405            
Glu Glu Asp Leu Phe Asn Pro Cys Gln Ala Ile Lys Cys Lys His Gly
    1410                1415                1420                
Lys Cys Arg Leu Ser Gly Leu Gly Gln Pro Tyr Cys Glu Cys Ser Ser
1425                1430                1435                1440
Gly Tyr Thr Gly Asp Ser Cys Asp Arg Glu Ile Ser Cys Arg Gly Glu
                1445                1450                1455    
Arg Ile Arg Asp Tyr Tyr Gln Lys Gln Gln Gly Tyr Ala Ala Cys Gln
            1460                1465                1470        
Thr Thr Lys Lys Val Ser Arg Leu Glu Cys Arg Gly Gly Cys Ala Gly
        1475                1480                1485            
Gly Gln Cys Cys Gly Pro Leu Arg Ser Lys Arg Arg Lys Tyr Ser Phe
    1490                1495                1500                
Glu Cys Thr Asp Gly Ser Ser Phe Val Asp Glu Val Glu Lys Val Val
1505                1510                1515                1520
Lys Cys Gly Cys Thr Arg Cys Val Ser
                1525                


<210> 9099
<211> 1521
<212> PRT
<213> Homo sapiens

<400> 9099
Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val
 1               5                  10                  15      
Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys
            20                  25                  30          
Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser
        35                  40                  45              
Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly
    50                  55                  60                  
Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His
65                  70                  75                  80  
Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg
                85                  90                  95      
Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg
            100                 105                 110         
Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys
        115                 120                 125             
Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg
    130                 135                 140                 
Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr
145                 150                 155                 160 
Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp
                165                 170                 175     
Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val
            180                 185                 190         
Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser
        195                 200                 205             
Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu
    210                 215                 220                 
Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser
225                 230                 235                 240 
His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val
                245                 250                 255     
Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His
            260                 265                 270         
Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly
        275                 280                 285             
Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu
    290                 295                 300                 
Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe
305                 310                 315                 320 
Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile
                325                 330                 335     
Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser
            340                 345                 350         
Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe
        355                 360                 365             
Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile
    370                 375                 380                 
Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu
385                 390                 395                 400 
Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe
                405                 410                 415     
Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe
            420                 425                 430         
Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn
        435                 440                 445             
Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala
    450                 455                 460                 
Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Gly
465                 470                 475                 480 
Thr Glu Asp Tyr Arg Ser Lys Leu Ser Gly Asp Cys Phe Ala Asp Leu
                485                 490                 495     
Ala Cys Pro Glu Lys Cys Arg Cys Glu Gly Thr Thr Val Asp Cys Ser
            500                 505                 510         
Asn Gln Lys Leu Asn Lys Ile Pro Glu His Ile Pro Gln Tyr Thr Ala
        515                 520                 525             
Glu Leu Arg Leu Asn Asn Asn Glu Phe Thr Val Leu Glu Ala Thr Gly
    530                 535                 540                 
Ile Phe Lys Lys Leu Pro Gln Leu Arg Lys Ile Asn Phe Ser Asn Asn
545                 550                 555                 560 
Lys Ile Thr Asp Ile Glu Glu Gly Ala Phe Glu Gly Ala Ser Gly Val
                565                 570                 575     
Asn Glu Ile Leu Leu Thr Ser Asn Arg Leu Glu Asn Val Gln His Lys
            580                 585                 590         
Met Phe Lys Gly Leu Glu Ser Leu Lys Thr Leu Met Leu Arg Ser Asn
        595                 600                 605             
Arg Ile Thr Cys Val Gly Asn Asp Ser Phe Ile Gly Leu Ser Ser Val
    610                 615                 620                 
Arg Leu Leu Ser Leu Tyr Asp Asn Gln Ile Thr Thr Val Ala Pro Gly
625                 630                 635                 640 
Ala Phe Asp Thr Leu His Ser Leu Ser Thr Leu Asn Leu Leu Ala Asn
                645                 650                 655     
Pro Phe Asn Cys Asn Cys Tyr Leu Ala Trp Leu Gly Glu Trp Leu Arg
            660                 665                 670         
Lys Lys Arg Ile Val Thr Gly Asn Pro Arg Cys Gln Lys Pro Tyr Phe
        675                 680                 685             
Leu Lys Glu Ile Pro Ile Gln Asp Val Ala Ile Gln Asp Phe Thr Cys
    690                 695                 700                 
Asp Asp Gly Asn Asp Asp Asn Ser Cys Ser Pro Leu Ser Arg Cys Pro
705                 710                 715                 720 
Thr Glu Cys Thr Cys Leu Asp Thr Val Val Arg Cys Ser Asn Lys Gly
                725                 730                 735     
Leu Lys Val Leu Pro Lys Gly Ile Pro Arg Asp Val Thr Glu Leu Tyr
            740                 745                 750         
Leu Asp Gly Asn Gln Phe Thr Leu Val Pro Lys Glu Leu Ser Asn Tyr
        755                 760                 765             
Lys His Leu Thr Leu Ile Asp Leu Ser Asn Asn Arg Ile Ser Thr Leu
    770                 775                 780                 
Ser Asn Gln Ser Phe Ser Asn Met Thr Gln Leu Leu Thr Leu Ile Leu
785                 790                 795                 800 
Ser Tyr Asn Arg Leu Arg Cys Ile Pro Pro Arg Thr Phe Asp Gly Leu
                805                 810                 815     
Lys Ser Leu Arg Leu Leu Ser Leu His Gly Asn Asp Ile Ser Val Val
            820                 825                 830         
Pro Glu Gly Ala Phe Asn Asp Leu Ser Ala Leu Ser His Leu Ala Ile
        835                 840                 845             
Gly Ala Asn Pro Leu Tyr Cys Asp Cys Asn Met Gln Trp Leu Ser Asp
    850                 855                 860                 
Trp Val Lys Ser Glu Tyr Lys Glu Pro Gly Ile Ala Arg Cys Ala Gly
865                 870                 875                 880 
Pro Gly Glu Met Ala Asp Lys Leu Leu Leu Thr Thr Pro Ser Lys Lys
                885                 890                 895     
Phe Thr Cys Gln Gly Pro Val Asp Val Asn Ile Leu Ala Lys Cys Asn
            900                 905                 910         
Pro Cys Leu Ser Asn Pro Cys Lys Asn Asp Gly Thr Cys Asn Ser Asp
        915                 920                 925             
Pro Val Asp Phe Tyr Arg Cys Thr Cys Pro Tyr Gly Phe Lys Gly Gln
    930                 935                 940                 
Asp Cys Asp Val Pro Ile His Ala Cys Ile Ser Asn Pro Cys Lys His
945                 950                 955                 960 
Gly Gly Thr Cys His Leu Lys Glu Gly Glu Glu Asp Gly Phe Trp Cys
                965                 970                 975     
Ile Cys Ala Asp Gly Phe Glu Gly Glu Asn Cys Glu Val Asn Val Asp
            980                 985                 990         
Asp Cys Glu Asp Asn Asp Cys Glu Asn Asn Ser Thr Cys Val Asp Gly
        995                 1000                1005            
Ile Asn Asn Tyr Thr Cys Leu Cys Pro Pro Glu Tyr Thr Gly Glu Leu
    1010                1015                1020                
Cys Glu Glu Lys Leu Asp Phe Cys Ala Gln Asp Leu Asn Pro Cys Gln
1025                1030                1035                1040
His Asp Ser Lys Cys Ile Leu Thr Pro Lys Gly Phe Lys Cys Asp Cys
                1045                1050                1055    
Thr Pro Gly Tyr Val Gly Glu His Cys Asp Ile Asp Phe Asp Asp Cys
            1060                1065                1070        
Gln Asp Asn Lys Cys Lys Asn Gly Ala His Cys Thr Asp Ala Val Asn
        1075                1080                1085            
Gly Tyr Thr Cys Ile Cys Pro Glu Gly Tyr Ser Gly Leu Phe Cys Glu
    1090                1095                1100                
Phe Ser Pro Pro Met Val Leu Pro Arg Thr Ser Pro Cys Asp Asn Phe
1105                1110                1115                1120
Asp Cys Gln Asn Gly Ala Gln Cys Ile Val Arg Ile Asn Glu Pro Ile
                1125                1130                1135    
Cys Gln Cys Leu Pro Gly Tyr Gln Gly Glu Lys Cys Glu Lys Leu Val
            1140                1145                1150        
Ser Val Asn Phe Ile Asn Lys Glu Ser Tyr Leu Gln Ile Pro Ser Ala
        1155                1160                1165            
Lys Val Arg Pro Gln Thr Asn Ile Thr Leu Gln Ile Ala Thr Asp Glu
    1170                1175                1180                
Asp Ser Gly Ile Leu Leu Tyr Lys Gly Asp Lys Asp His Ile Ala Val
1185                1190                1195                1200
Glu Leu Tyr Arg Gly Arg Val Arg Ala Ser Tyr Asp Thr Gly Ser His
                1205                1210                1215    
Pro Ala Ser Ala Ile Tyr Ser Val Glu Thr Ile Asn Asp Gly Asn Phe
            1220                1225                1230        
His Ile Val Glu Leu Leu Ala Leu Asp Gln Ser Leu Ser Leu Ser Val
        1235                1240                1245            
Asp Gly Gly Asn Pro Lys Ile Ile Thr Asn Leu Ser Lys Gln Ser Thr
    1250                1255                1260                
Leu Asn Phe Asp Ser Pro Leu Tyr Val Gly Gly Met Pro Gly Lys Ser
1265                1270                1275                1280
Asn Val Ala Ser Leu Arg Gln Ala Pro Gly Gln Asn Gly Thr Ser Phe
                1285                1290                1295    
His Gly Cys Ile Arg Asn Leu Tyr Ile Asn Ser Glu Leu Gln Asp Phe
            1300                1305                1310        
Gln Lys Val Pro Met Gln Thr Gly Ile Leu Pro Gly Cys Glu Pro Cys
        1315                1320                1325            
His Lys Lys Val Cys Ala His Gly Thr Cys Gln Pro Ser Ser Gln Ala
    1330                1335                1340                
Gly Phe Thr Cys Glu Cys Gln Glu Gly Trp Met Gly Pro Leu Cys Asp
1345                1350                1355                1360
Gln Arg Thr Asn Asp Pro Cys Leu Gly Asn Lys Cys Val His Gly Thr
                1365                1370                1375    
Cys Leu Pro Ile Asn Ala Phe Ser Tyr Ser Cys Lys Cys Leu Glu Gly
            1380                1385                1390        
His Gly Gly Val Leu Cys Asp Glu Glu Glu Asp Leu Phe Asn Pro Cys
        1395                1400                1405            
Gln Ala Ile Lys Cys Lys His Gly Lys Cys Arg Leu Ser Gly Leu Gly
    1410                1415                1420                
Gln Pro Tyr Cys Glu Cys Ser Ser Gly Tyr Thr Gly Asp Ser Cys Asp
1425                1430                1435                1440
Arg Glu Ile Ser Cys Arg Gly Glu Arg Ile Arg Asp Tyr Tyr Gln Lys
                1445                1450                1455    
Gln Gln Gly Tyr Ala Ala Cys Gln Thr Thr Lys Lys Val Ser Arg Leu
            1460                1465                1470        
Glu Cys Arg Gly Gly Cys Ala Gly Gly Gln Cys Cys Gly Pro Leu Arg
        1475                1480                1485            
Ser Lys Arg Arg Lys Tyr Ser Phe Glu Cys Thr Asp Gly Ser Ser Phe
    1490                1495                1500                
Val Asp Glu Val Glu Lys Val Val Lys Cys Gly Cys Thr Arg Cys Val
1505                1510                1515                1520
Ser
    


<210> 9100
<211> 794
<212> PRT
<213> Homo sapiens

<400> 9100
Met Leu Thr Arg Asn Cys Leu Ser Leu Leu Leu Trp Val Leu Phe Asp
 1               5                  10                  15      
Gly Gly Leu Leu Thr Pro Leu Gln Pro Gln Pro Gln Gln Thr Leu Ala
            20                  25                  30          
Thr Glu Pro Arg Glu Asn Val Ile His Leu Pro Gly Gln Arg Ser His
        35                  40                  45              
Phe Gln Arg Val Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu
    50                  55                  60                  
Glu Glu Tyr Val Gly Ser Glu Pro Gln Tyr Val Gly Lys Leu His Ser
65                  70                  75                  80  
Asp Leu Asp Lys Gly Glu Gly Thr Val Lys Tyr Thr Leu Ser Gly Asp
                85                  90                  95      
Gly Ala Gly Thr Val Phe Thr Ile Asp Glu Thr Thr Gly Asp Ile His
            100                 105                 110         
Ala Ile Arg Ser Leu Asp Arg Glu Glu Lys Pro Phe Tyr Thr Leu Arg
        115                 120                 125             
Ala Gln Ala Val Asp Ile Glu Thr Arg Lys Pro Leu Glu Pro Glu Ser
    130                 135                 140                 
Glu Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Glu Pro Lys Phe
145                 150                 155                 160 
Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu Met Ser Pro Val Gly
                165                 170                 175     
Ala Tyr Val Leu Gln Val Lys Ala Thr Asp Ala Asp Asp Pro Thr Tyr
            180                 185                 190         
Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr
        195                 200                 205             
Phe Ser Ile Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu Pro Asn
    210                 215                 220                 
Met Asp Arg Glu Val Lys Glu Gln Tyr Gln Val Leu Ile Gln Ala Lys
225                 230                 235                 240 
Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly Thr Thr Ile Val Asn
                245                 250                 255     
Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Lys Ser
            260                 265                 270         
Ile Phe His Leu Lys Val Pro Glu Ser Ser Pro Ile Gly Ser Ala Ile
        275                 280                 285             
Gly Arg Ile Arg Ala Val Asp Pro Asp Phe Gly Gln Asn Ala Glu Ile
    290                 295                 300                 
Glu Tyr Asn Ile Val Pro Gly Asp Gly Gly Asn Leu Phe Asp Ile Val
305                 310                 315                 320 
Thr Asp Glu Asp Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Leu
                325                 330                 335     
Asp Phe Glu Thr Lys Lys Ala Tyr Thr Phe Lys Val Glu Ala Ser Asn
            340                 345                 350         
Leu His Leu Asp His Arg Phe His Ser Ala Gly Pro Phe Lys Asp Thr
        355                 360                 365             
Ala Thr Val Lys Ile Ser Val Leu Asp Val Asp Glu Pro Pro Val Phe
    370                 375                 380                 
Ser Lys Pro Leu Tyr Thr Met Glu Val Tyr Glu Asp Thr Pro Val Gly
385                 390                 395                 400 
Thr Ile Ile Gly Ala Val Thr Ala Gln Asp Leu Asp Val Gly Ser Gly
                405                 410                 415     
Ala Val Arg Tyr Phe Ile Asp Trp Lys Ser Asp Gly Asp Ser Tyr Phe
            420                 425                 430         
Thr Ile Asp Gly Asn Glu Gly Thr Ile Ala Thr Asn Glu Leu Leu Asp
        435                 440                 445             
Arg Glu Ser Thr Ala Gln Tyr Asn Phe Ser Ile Ile Ala Ser Lys Val
    450                 455                 460                 
Ser Asn Pro Leu Leu Thr Ser Lys Val Asn Ile Leu Ile Asn Val Leu
465                 470                 475                 480 
Asp Val Asn Glu Phe Pro Pro Glu Ile Ser Val Pro Tyr Glu Thr Ala
                485                 490                 495     
Val Cys Glu Asn Ala Lys Pro Gly Gln Ile Ile Gln Ile Val Ser Ala
            500                 505                 510         
Ala Asp Arg Asp Leu Ser Pro Ala Gly Gln Gln Phe Ser Phe Arg Leu
        515                 520                 525             
Ser Pro Glu Ala Ala Ile Lys Pro Asn Phe Thr Val Arg Asp Phe Arg
    530                 535                 540                 
Asn Asn Thr Ala Gly Ile Glu Thr Arg Arg Asn Gly Tyr Ser Arg Arg
545                 550                 555                 560 
Gln Gln Glu Leu Tyr Phe Leu Pro Val Val Ile Glu Asp Ser Ser Tyr
                565                 570                 575     
Pro Val Gln Ser Ser Thr Asn Thr Met Thr Ile Arg Val Cys Arg Cys
            580                 585                 590         
Asp Ser Asp Gly Thr Ile Leu Ser Cys Asn Val Glu Ala Ile Phe Leu
        595                 600                 605             
Pro Val Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile
    610                 615                 620                 
Val Ile Leu Leu Ala Ile Val Val Leu Tyr Val Ala Leu Arg Arg Gln
625                 630                 635                 640 
Lys Lys Lys His Thr Leu Met Thr Ser Lys Glu Asp Ile Arg Asp Asn
                645                 650                 655     
Val Ile His Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala
            660                 665                 670         
Phe Asp Ile Gly Ala Leu Arg Asn Pro Lys Val Ile Glu Glu Asn Lys
        675                 680                 685             
Ile Arg Arg Asp Ile Lys Pro Asp Ser Leu Cys Leu Pro Arg Gln Arg
    690                 695                 700                 
Pro Pro Met Glu Asp Asn Thr Asp Ile Arg Asp Phe Ile His Gln Arg
705                 710                 715                 720 
Leu Gln Glu Asn Asp Val Asp Pro Thr Ala Pro Pro Ile Asp Ser Leu
                725                 730                 735     
Ala Thr Tyr Ala Tyr Glu Gly Ser Gly Ser Val Ala Glu Ser Leu Ser
            740                 745                 750         
Ser Ile Asp Ser Leu Thr Thr Glu Ala Asp Gln Asp Tyr Asp Tyr Leu
        755                 760                 765             
Thr Asp Trp Gly Pro Arg Phe Lys Val Leu Ala Asp Met Phe Gly Glu
    770                 775                 780                 
Glu Glu Ser Tyr Asn Pro Asp Lys Val Thr
785                 790                 


<210> 9101
<211> 794
<212> PRT
<213> Homo sapiens

<400> 9101
Met Leu Thr Arg Asn Cys Leu Ser Leu Leu Leu Trp Val Leu Phe Asp
 1               5                  10                  15      
Gly Gly Leu Leu Thr Pro Leu Gln Pro Gln Pro Gln Gln Thr Leu Ala
            20                  25                  30          
Thr Glu Pro Arg Glu Asn Val Ile His Leu Pro Gly Gln Arg Ser His
        35                  40                  45              
Phe Gln Arg Val Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu
    50                  55                  60                  
Glu Glu Tyr Val Gly Ser Glu Pro Gln Tyr Val Gly Lys Leu His Ser
65                  70                  75                  80  
Asp Leu Asp Lys Gly Glu Gly Thr Val Lys Tyr Thr Leu Ser Gly Asp
                85                  90                  95      
Gly Ala Gly Thr Val Phe Thr Ile Asp Glu Thr Thr Gly Asp Ile His
            100                 105                 110         
Ala Ile Arg Ser Leu Asp Arg Glu Glu Lys Pro Phe Tyr Thr Leu Arg
        115                 120                 125             
Ala Gln Ala Val Asp Ile Glu Thr Arg Lys Pro Leu Glu Pro Glu Ser
    130                 135                 140                 
Glu Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Glu Pro Lys Phe
145                 150                 155                 160 
Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu Met Ser Pro Val Gly
                165                 170                 175     
Ala Tyr Val Leu Gln Val Lys Ala Thr Asp Ala Asp Asp Pro Thr Tyr
            180                 185                 190         
Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr
        195                 200                 205             
Phe Ser Ile Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu Pro Asn
    210                 215                 220                 
Met Asp Arg Glu Val Lys Glu Gln Tyr Gln Val Leu Ile Gln Ala Lys
225                 230                 235                 240 
Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly Thr Thr Ile Val Asn
                245                 250                 255     
Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Lys Ser
            260                 265                 270         
Ile Phe His Leu Lys Val Pro Glu Ser Ser Pro Ile Gly Ser Ala Ile
        275                 280                 285             
Gly Arg Ile Arg Ala Val Asp Pro Asp Phe Gly Gln Asn Ala Glu Ile
    290                 295                 300                 
Glu Tyr Asn Ile Val Pro Gly Asp Gly Gly Asn Leu Phe Asp Ile Val
305                 310                 315                 320 
Thr Asp Glu Asp Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Leu
                325                 330                 335     
Asp Phe Glu Thr Lys Lys Ala Tyr Thr Phe Lys Val Glu Ala Ser Asn
            340                 345                 350         
Leu His Leu Asp His Arg Phe His Ser Ala Gly Pro Phe Lys Asp Thr
        355                 360                 365             
Ala Thr Val Lys Ile Ser Val Leu Asp Val Asp Glu Pro Pro Val Phe
    370                 375                 380                 
Ser Lys Pro Leu Tyr Thr Met Glu Val Tyr Glu Asp Thr Pro Val Gly
385                 390                 395                 400 
Thr Ile Ile Gly Ala Val Thr Ala Gln Asp Leu Asp Val Gly Ser Ser
                405                 410                 415     
Ala Val Arg Tyr Phe Ile Asp Trp Lys Ser Asp Gly Asp Ser Tyr Phe
            420                 425                 430         
Thr Ile Asp Gly Asn Glu Gly Thr Ile Ala Thr Asn Glu Leu Leu Asp
        435                 440                 445             
Arg Glu Ser Thr Ala Gln Tyr Asn Phe Ser Ile Ile Ala Ser Lys Val
    450                 455                 460                 
Ser Asn Pro Leu Leu Thr Ser Lys Val Asn Ile Leu Ile Asn Val Leu
465                 470                 475                 480 
Asp Val Asn Glu Phe Pro Pro Glu Ile Ser Val Pro Tyr Glu Thr Ala
                485                 490                 495     
Val Cys Glu Asn Ala Lys Pro Gly Gln Ile Ile Gln Ile Val Ser Ala
            500                 505                 510         
Ala Asp Arg Asp Leu Ser Pro Ala Gly Gln Gln Phe Ser Phe Arg Leu
        515                 520                 525             
Ser Pro Glu Ala Ala Ile Lys Pro Asn Phe Thr Val Arg Asp Phe Arg
    530                 535                 540                 
Asn Asn Thr Ala Gly Ile Glu Thr Arg Arg Asn Gly Tyr Ser Arg Arg
545                 550                 555                 560 
Gln Gln Glu Leu Tyr Phe Leu Pro Val Val Ile Glu Asp Ser Ser Tyr
                565                 570                 575     
Pro Val Gln Ser Ser Thr Asn Thr Met Thr Ile Arg Val Cys Arg Cys
            580                 585                 590         
Asp Ser Asp Gly Thr Ile Leu Ser Cys Asn Val Glu Ala Ile Phe Leu
        595                 600                 605             
Pro Val Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile
    610                 615                 620                 
Val Ile Leu Leu Ala Ile Val Val Leu Tyr Val Ala Leu Arg Arg Gln
625                 630                 635                 640 
Lys Lys Lys Asp Thr Leu Met Thr Ser Lys Glu Asp Ile Arg Asp Asn
                645                 650                 655     
Val Ile His Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala
            660                 665                 670         
Phe Asp Ile Gly Ala Leu Arg Asn Pro Lys Val Ile Glu Glu Asn Lys
        675                 680                 685             
Ile Arg Arg Asp Ile Lys Pro Asp Ser Leu Cys Leu Pro Arg Gln Arg
    690                 695                 700                 
Pro Pro Met Glu Asp Asn Thr Asp Ile Arg Asp Phe Ile His Gln Arg
705                 710                 715                 720 
Leu Gln Glu Asn Asp Val Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu
                725                 730                 735     
Ala Thr Tyr Ala Tyr Glu Gly Ser Gly Ser Val Ala Glu Ser Leu Ser
            740                 745                 750         
Ser Ile Asp Ser Leu Thr Thr Glu Ala Asp Gln Asp Tyr Asp Tyr Leu
        755                 760                 765             
Thr Asp Trp Gly Pro Arg Phe Lys Val Leu Ala Asp Met Phe Gly Glu
    770                 775                 780                 
Glu Glu Ser Tyr Asn Pro Asp Lys Val Thr
785                 790                 


<210> 9102
<211> 1028
<212> PRT
<213> Homo sapiens

<400> 9102
Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp
 1               5                  10                  15      
Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln
            20                  25                  30          
Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val
        35                  40                  45              
Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser
    50                  55                  60                  
Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys
65                  70                  75                  80  
Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu
                85                  90                  95      
Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala
            100                 105                 110         
Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr
        115                 120                 125             
Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly
    130                 135                 140                 
Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His
145                 150                 155                 160 
Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val
                165                 170                 175     
Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr
            180                 185                 190         
Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr
        195                 200                 205             
Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala
    210                 215                 220                 
Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys
225                 230                 235                 240 
Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg
                245                 250                 255     
Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly
            260                 265                 270         
Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg
        275                 280                 285             
Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys
    290                 295                 300                 
Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly
305                 310                 315                 320 
Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu
                325                 330                 335     
Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp
            340                 345                 350         
Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly
        355                 360                 365             
Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg
    370                 375                 380                 
Pro Gly Ala Arg Gly Pro Ser Gly Asp Glu Gly Pro Ala Gly Glu Pro
385                 390                 395                 400 
Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly
                405                 410                 415     
Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro
            420                 425                 430         
Arg Gly Thr Pro Gly Pro Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala
        435                 440                 445             
Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly
    450                 455                 460                 
Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp
465                 470                 475                 480 
Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala
                485                 490                 495     
Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly
            500                 505                 510         
Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro
        515                 520                 525             
Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly
    530                 535                 540                 
Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn
545                 550                 555                 560 
Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro
                565                 570                 575     
Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp
            580                 585                 590         
Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu
        595                 600                 605             
Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu
    610                 615                 620                 
Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys
625                 630                 635                 640 
Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly
                645                 650                 655     
Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu
            660                 665                 670         
His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys
        675                 680                 685             
Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly
    690                 695                 700                 
Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn
705                 710                 715                 720 
Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg
                725                 730                 735     
Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val
            740                 745                 750         
Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln
        755                 760                 765             
Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro
    770                 775                 780                 
Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala
785                 790                 795                 800 
Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro
                805                 810                 815     
Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile
            820                 825                 830         
Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr
        835                 840                 845             
Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg
    850                 855                 860                 
Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly
865                 870                 875                 880 
Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn
                885                 890                 895     
Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp
            900                 905                 910         
Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg
        915                 920                 925             
Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp
    930                 935                 940                 
Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln
945                 950                 955                 960 
Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg
                965                 970                 975     
Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala
            980                 985                 990         
Glu Tyr Asp Val Pro Tyr Gly Glu Ser His Leu Phe Arg Val Pro Ser
        995                 1000                1005            
Tyr Gln Ala Leu Leu Arg Gly Val Phe His Gln Thr Val Ser Arg Lys
    1010                1015                1020                
Val Ala Leu Gly
1025            


<210> 9103
<211> 188
<212> PRT
<213> Homo sapiens

<400> 9103
Met Glu Ala Arg Phe Thr Arg Gly Lys Ser Ala Leu Leu Glu Arg Ala
 1               5                  10                  15      
Leu Ala Arg Pro Arg Thr Glu Val Ser Leu Ser Ala Phe Ala Leu Leu
            20                  25                  30          
Phe Ser Glu Leu Val Gln His Cys Gln Ser Arg Val Phe Ser Val Ala
        35                  40                  45              
Glu Leu Gln Ser Arg Leu Ala Ala Leu Gly Arg Gln Val Gly Ala Arg
    50                  55                  60                  
Val Leu Asp Ala Leu Val Ala Arg Glu Lys Gly Ala Arg Arg Glu Thr
65                  70                  75                  80  
Lys Val Leu Gly Ala Leu Leu Phe Val Lys Gly Ala Val Trp Lys Ala
                85                  90                  95      
Leu Phe Gly Lys Glu Ala Asp Lys Leu Glu Gln Ala Asn Asp Asp Ala
            100                 105                 110         
Arg Thr Phe Tyr Ile Ile Glu Arg Glu Pro Leu Ile Asn Thr Tyr Ile
        115                 120                 125             
Ser Val Pro Lys Glu Asn Ser Thr Leu Asn Cys Ala Ser Phe Thr Ala
    130                 135                 140                 
Gly Ile Val Glu Ala Val Leu Thr His Ser Gly Phe Pro Ala Lys Val
145                 150                 155                 160 
Thr Ala His Trp His Lys Gly Thr Thr Leu Met Ile Lys Phe Glu Glu
                165                 170                 175     
Ala Val Ile Ala Arg Asp Arg Ala Leu Glu Gly Arg
            180                 185             


<210> 9104
<211> 1241
<212> PRT
<213> Homo sapiens

<400> 9104
Met Ile Met Phe Pro Leu Phe Gly Lys Ile Ser Leu Gly Ile Leu Ile
 1               5                  10                  15      
Phe Val Leu Ile Glu Gly Asp Phe Pro Ser Leu Thr Ala Gln Thr Tyr
            20                  25                  30          
Leu Ser Ile Glu Glu Ile Gln Glu Pro Lys Ser Ala Val Ser Phe Leu
        35                  40                  45              
Leu Pro Glu Glu Ser Thr Asp Leu Ser Leu Ala Thr Lys Lys Lys Gln
    50                  55                  60                  
Pro Leu Asp Arg Arg Glu Thr Glu Arg Gln Trp Leu Ile Arg Arg Arg
65                  70                  75                  80  
Arg Ser Ile Leu Phe Pro Asn Gly Val Lys Ile Cys Pro Asp Glu Ser
                85                  90                  95      
Val Ala Glu Ala Val Ala Asn His Val Lys Tyr Phe Lys Val Arg Val
            100                 105                 110         
Cys Gln Glu Ala Val Trp Glu Ala Phe Arg Thr Phe Trp Asp Arg Leu
        115                 120                 125             
Pro Gly Arg Glu Glu Tyr His Tyr Trp Met Asn Leu Cys Glu Asp Gly
    130                 135                 140                 
Val Thr Ser Ile Phe Glu Met Gly Thr Asn Phe Ser Glu Ser Val Glu
145                 150                 155                 160 
His Arg Ser Leu Ile Met Lys Lys Leu Thr Tyr Ala Lys Glu Thr Val
                165                 170                 175     
Ser Ser Ser Glu Leu Ser Ser Pro Val Pro Val Gly Asp Thr Ser Thr
            180                 185                 190         
Leu Gly Asp Thr Thr Leu Ser Val Pro His Pro Glu Val Asp Ala Tyr
        195                 200                 205             
Glu Gly Ala Ser Glu Ser Ser Leu Glu Arg Pro Glu Glu Ser Ile Ser
    210                 215                 220                 
Asn Glu Ile Glu Asn Val Ile Glu Glu Ala Thr Lys Pro Ala Gly Glu
225                 230                 235                 240 
Gln Ile Ala Glu Phe Ser Ile His Leu Leu Gly Lys Gln Tyr Arg Glu
                245                 250                 255     
Glu Leu Gln Asp Ser Ser Ser Phe His His Gln His Leu Glu Glu Glu
            260                 265                 270         
Phe Ile Ser Glu Val Glu Asn Ala Phe Thr Gly Leu Pro Gly Tyr Lys
        275                 280                 285             
Glu Ile Arg Val Leu Glu Phe Arg Ser Pro Lys Glu Asn Asp Ser Gly
    290                 295                 300                 
Val Asp Val Tyr Tyr Ala Val Thr Phe Asn Gly Glu Ala Ile Ser Asn
305                 310                 315                 320 
Thr Thr Trp Asp Leu Ile Ser Leu His Ser Asn Lys Val Glu Asn His
                325                 330                 335     
Gly Leu Val Glu Leu Asp Asp Lys Pro Thr Val Val Tyr Thr Ile Ser
            340                 345                 350         
Asn Phe Arg Asp Tyr Ile Ala Glu Thr Leu Gln Gln Asn Phe Leu Leu
        355                 360                 365             
Gly Asn Ser Ser Leu Asn Pro Asp Pro Asp Ser Leu Gln Leu Ile Asn
    370                 375                 380                 
Val Arg Gly Val Leu Arg His Gln Thr Glu Asp Leu Val Trp Asn Thr
385                 390                 395                 400 
Gln Ser Ser Ser Leu Gln Ala Thr Pro Ser Ser Ile Leu Asp Asn Thr
                405                 410                 415     
Phe Gln Ala Ala Trp Pro Ser Ala Asp Glu Ser Ile Thr Ser Ser Ile
            420                 425                 430         
Pro Pro Leu Asp Phe Ser Ser Gly Pro Pro Ser Ala Thr Gly Arg Glu
        435                 440                 445             
Leu Trp Ser Glu Ser Pro Leu Gly Asp Leu Val Ser Thr His Lys Leu
    450                 455                 460                 
Ala Phe Pro Ser Lys Met Gly Leu Ser Ser Ser Pro Glu Val Leu Glu
465                 470                 475                 480 
Val Ser Ser Leu Thr Leu His Ser Val Thr Pro Ala Val Leu Gln Thr
                485                 490                 495     
Gly Leu Pro Val Ala Ser Glu Glu Arg Thr Ser Gly Ser His Leu Val
            500                 505                 510         
Glu Asp Gly Leu Ala Asn Val Glu Glu Ser Glu Asp Phe Leu Ser Ile
        515                 520                 525             
Asp Ser Leu Pro Ser Ser Ser Phe Thr Gln Pro Val Pro Lys Glu Thr
    530                 535                 540                 
Ile Pro Ser Met Glu Asp Ser Asp Val Ser Leu Thr Ser Ser Pro Tyr
545                 550                 555                 560 
Leu Thr Ser Ser Ile Pro Phe Gly Leu Asp Ser Leu Thr Ser Lys Val
                565                 570                 575     
Lys Asp Gln Leu Lys Val Ser Pro Phe Leu Pro Asp Ala Ser Met Glu
            580                 585                 590         
Lys Glu Leu Ile Phe Asp Gly Gly Leu Gly Ser Gly Ser Gly Gln Lys
        595                 600                 605             
Val Asp Leu Ile Thr Trp Pro Trp Ser Glu Thr Ser Ser Glu Lys Ser
    610                 615                 620                 
Ala Glu Pro Leu Ser Lys Pro Trp Leu Glu Asp Asp Asp Ser Leu Leu
625                 630                 635                 640 
Pro Ala Glu Ile Glu Asp Lys Lys Leu Val Leu Val Asp Lys Met Asp
                645                 650                 655     
Ser Thr Asp Gln Ile Ser Lys His Ser Lys Tyr Glu His Asp Asp Arg
            660                 665                 670         
Ser Thr His Phe Pro Glu Glu Glu Pro Leu Ser Gly Pro Ala Val Pro
        675                 680                 685             
Ile Phe Ala Asp Thr Ala Ala Glu Ser Ala Ser Leu Thr Leu Pro Lys
    690                 695                 700                 
His Ile Ser Glu Val Pro Gly Val Asp Asp Cys Ser Val Thr Lys Ala
705                 710                 715                 720 
Pro Leu Ile Leu Thr Ser Val Ala Ile Ser Ala Ser Thr Asp Lys Ser
                725                 730                 735     
Asp Gln Ala Asp Ala Ile Leu Arg Glu Asp Met Glu Gln Ile Thr Glu
            740                 745                 750         
Ser Ser Asn Tyr Glu Trp Phe Asp Ser Glu Val Ser Met Val Lys Pro
        755                 760                 765             
Asp Met Gln Thr Leu Trp Thr Ile Leu Pro Glu Ser Glu Arg Val Trp
    770                 775                 780                 
Thr Arg Thr Ser Ser Leu Glu Lys Leu Ser Arg Asp Ile Leu Ala Ser
785                 790                 795                 800 
Thr Pro Gln Ser Ala Asp Arg Leu Trp Leu Ser Val Thr Gln Ser Thr
                805                 810                 815     
Lys Leu Pro Pro Thr Thr Ile Ser Thr Leu Leu Glu Asp Glu Val Ile
            820                 825                 830         
Met Gly Val Gln Asp Ile Ser Leu Glu Leu Asp Arg Ile Gly Thr Asp
        835                 840                 845             
Tyr Tyr Gln Pro Glu Gln Val Gln Glu Gln Asn Gly Lys Val Gly Ser
    850                 855                 860                 
Tyr Val Glu Met Ser Thr Ser Val His Ser Thr Glu Met Val Ser Val
865                 870                 875                 880 
Ala Trp Pro Thr Glu Gly Gly Asp Asp Leu Ser Tyr Thr Gln Thr Ser
                885                 890                 895     
Gly Ala Leu Val Val Phe Phe Ser Leu Arg Val Thr Asn Met Met Phe
            900                 905                 910         
Ser Glu Asp Leu Phe Asn Lys Asn Ser Leu Glu Tyr Lys Ala Leu Glu
        915                 920                 925             
Gln Arg Phe Leu Glu Leu Leu Val Pro Tyr Leu Gln Ser Asn Leu Thr
    930                 935                 940                 
Gly Phe Gln Asn Leu Glu Ile Leu Asn Phe Arg Asn Gly Ser Ile Val
945                 950                 955                 960 
Val Asn Ser Arg Met Lys Phe Ala Asn Ser Val Pro Pro Asn Val Asn
                965                 970                 975     
Asn Ala Val Tyr Met Ile Leu Glu Asp Phe Cys Thr Thr Ala Tyr Asn
            980                 985                 990         
Thr Met Asn Leu Ala Ile Asp Lys Tyr Ser Leu Asp Val Glu Ser Gly
        995                 1000                1005            
Asp Glu Ala Asn Pro Cys Lys Phe Gln Ala Cys Asn Glu Phe Ser Glu
    1010                1015                1020                
Cys Leu Val Asn Pro Trp Ser Gly Glu Ala Lys Cys Arg Cys Phe Pro
1025                1030                1035                1040
Gly Tyr Leu Ser Val Glu Glu Arg Pro Cys Gln Ser Leu Cys Asp Leu
                1045                1050                1055    
Gln Pro Asp Phe Cys Leu Asn Asp Gly Lys Cys Asp Ile Met Pro Gly
            1060                1065                1070        
His Gly Ala Ile Cys Arg Cys Arg Val Gly Glu Asn Trp Trp Tyr Arg
        1075                1080                1085            
Gly Lys His Cys Glu Glu Phe Val Ser Glu Pro Val Ile Ile Gly Ile
    1090                1095                1100                
Thr Ile Ala Ser Val Val Gly Leu Leu Val Ile Phe Ser Ala Ile Ile
1105                1110                1115                1120
Tyr Phe Phe Ile Arg Thr Leu Gln Ala His His Asp Arg Ser Glu Arg
                1125                1130                1135    
Glu Ser Pro Phe Ser Gly Ser Ser Arg Gln Pro Asp Ser Leu Ser Ser
            1140                1145                1150        
Ile Glu Asn Ala Val Lys Tyr Asn Pro Val Tyr Glu Ser His Arg Ala
        1155                1160                1165            
Gly Cys Glu Lys Tyr Glu Gly Pro Tyr Pro Gln His Pro Phe Tyr Ser
    1170                1175                1180                
Ser Ala Ser Gly Asp Val Ile Gly Gly Leu Ser Arg Glu Glu Ile Arg
1185                1190                1195                1200
Gln Met Tyr Glu Ser Ser Glu Leu Ser Arg Glu Glu Ile Gln Glu Arg
                1205                1210                1215    
Met Arg Val Leu Glu Leu Tyr Ala Asn Asp Pro Glu Phe Ala Ala Phe
            1220                1225                1230        
Val Arg Glu Gln Gln Val Glu Glu Val
        1235                1240    


<210> 9105
<211> 590
<212> PRT
<213> Homo sapiens

<400> 9105
Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly
 1               5                  10                  15      
Pro Arg Thr Cys Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp
            20                  25                  30          
Ala Glu Pro Ala Ser Val Ile Ala Arg Gly Lys Pro Val Thr Leu Trp
        35                  40                  45              
Cys Gln Gly Pro Leu Glu Thr Glu Glu Tyr Arg Leu Asp Lys Glu Gly
    50                  55                  60                  
Leu Pro Trp Ala Arg Lys Arg Gln Asn Pro Leu Glu Pro Gly Ala Lys
65                  70                  75                  80  
Ala Lys Phe His Ile Pro Ser Thr Val Tyr Asp Ser Ala Gly Arg Tyr
                85                  90                  95      
Arg Cys Tyr Tyr Glu Thr Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro
            100                 105                 110         
Leu Glu Leu Val Ala Thr Gly Phe Tyr Ala Glu Pro Thr Leu Leu Ala
        115                 120                 125             
Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Val Thr Leu Gln Cys
    130                 135                 140                 
Asp Thr Leu Asp Gly Leu Leu Thr Phe Val Leu Val Glu Glu Glu Gln
145                 150                 155                 160 
Lys Leu Pro Arg Thr Leu Tyr Ser Gln Lys Leu Pro Lys Gly Pro Ser
                165                 170                 175     
Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser Cys Arg Trp Arg
            180                 185                 190         
Phe Arg Cys Tyr Tyr Tyr Tyr Arg Lys Asn Pro Gln Val Trp Ser Asn
        195                 200                 205             
Pro Ser Asp Leu Leu Glu Ile Leu Val Pro Gly Val Ser Arg Lys Pro
    210                 215                 220                 
Ser Leu Leu Ile Pro Gln Gly Ser Val Val Ala Arg Gly Gly Ser Leu
225                 230                 235                 240 
Thr Leu Gln Cys Arg Ser Asp Val Gly Tyr Asp Ile Phe Val Leu Tyr
                245                 250                 255     
Lys Glu Gly Glu His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln
            260                 265                 270         
Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser
        275                 280                 285             
His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Pro Arg
    290                 295                 300                 
Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Leu Ile
305                 310                 315                 320 
Pro Asp Ile Pro Ala Leu Ser Val Gln Pro Gly Pro Lys Val Ala Ser
                325                 330                 335     
Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp His Gln Ile Asp Thr
            340                 345                 350         
Phe Phe Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Cys Leu Lys
        355                 360                 365             
Ser Lys Tyr Gln Ser Tyr Arg His Gln Ala Glu Phe Ser Met Ser Pro
    370                 375                 380                 
Val Thr Ser Ala Gln Gly Gly Thr Tyr Arg Cys Tyr Ser Ala Ile Arg
385                 390                 395                 400 
Ser Tyr Pro Tyr Leu Leu Ser Ser Pro Ser Tyr Pro Gln Glu Leu Val
                405                 410                 415     
Val Ser Gly Pro Ser Gly Asp Pro Ser Leu Ser Pro Thr Gly Ser Thr
            420                 425                 430         
Pro Thr Pro Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Leu Asp
        435                 440                 445             
Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Thr Gly Val Ser
    450                 455                 460                 
Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu Arg
465                 470                 475                 480 
His Arg His Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg Pro
                485                 490                 495     
Ala Gly Ala Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys Arg
            500                 505                 510         
Ala Ser Pro Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala Val
        515                 520                 525             
Lys Asp Thr Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala Ala
    530                 535                 540                 
Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu
545                 550                 555                 560 
Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg Glu
                565                 570                 575     
Pro Pro Ala Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His
            580                 585                 590 


<210> 9106
<211> 491
<212> PRT
<213> Homo sapiens

<400> 9106
Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly
 1               5                  10                  15      
Pro Arg Thr Cys Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp
            20                  25                  30          
Ala Glu Pro Ala Ser Val Ile Ala Arg Gly Lys Pro Val Thr Leu Trp
        35                  40                  45              
Cys Gln Gly Pro Leu Glu Thr Glu Glu Tyr Arg Leu Asp Lys Glu Gly
    50                  55                  60                  
Leu Pro Trp Ala Arg Lys Arg Gln Asn Pro Leu Glu Pro Gly Ala Lys
65                  70                  75                  80  
Ala Lys Phe His Ile Pro Ser Thr Val Tyr Asp Ser Ala Gly Arg Tyr
                85                  90                  95      
Arg Cys Tyr Tyr Glu Thr Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro
            100                 105                 110         
Leu Glu Leu Val Ala Thr Gly Val Ser Arg Lys Pro Ser Leu Leu Ile
        115                 120                 125             
Pro Gln Gly Ser Val Val Ala Arg Gly Gly Ser Leu Thr Leu Gln Cys
    130                 135                 140                 
Arg Ser Asp Val Gly Tyr Asp Ile Phe Val Leu Tyr Lys Glu Gly Glu
145                 150                 155                 160 
His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln Ala Gly Leu Ser
                165                 170                 175     
Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser His Gly Gly Gln
            180                 185                 190         
Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Pro Arg Trp Ser Ala Pro
        195                 200                 205             
Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Leu Ile Pro Asp Ile Pro
    210                 215                 220                 
Ala Leu Ser Val Gln Pro Gly Pro Lys Val Ala Ser Gly Glu Asn Val
225                 230                 235                 240 
Thr Leu Leu Cys Gln Ser Trp His Gln Ile Asp Thr Phe Phe Leu Thr
                245                 250                 255     
Lys Glu Gly Ala Ala His Pro Pro Leu Cys Leu Lys Ser Lys Tyr Gln
            260                 265                 270         
Ser Tyr Arg His Gln Ala Glu Phe Ser Met Ser Pro Val Thr Ser Ala
        275                 280                 285             
Gln Gly Gly Thr Tyr Arg Cys Tyr Ser Ala Ile Arg Ser Tyr Pro Tyr
    290                 295                 300                 
Leu Leu Ser Ser Pro Ser Tyr Pro Gln Glu Leu Val Val Ser Gly Pro
305                 310                 315                 320 
Ser Gly Asp Pro Ser Leu Ser Pro Thr Gly Ser Thr Pro Thr Pro Ala
                325                 330                 335     
Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Leu Asp Pro Gln Ser
            340                 345                 350         
Gly Leu Gly Arg His Leu Gly Val Val Thr Gly Val Ser Val Ala Phe
        355                 360                 365             
Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu Arg His Arg His
    370                 375                 380                 
Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg Pro Ala Gly Ala
385                 390                 395                 400 
Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys Arg Ala Ser Pro
                405                 410                 415     
Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala Val Lys Asp Thr
            420                 425                 430         
Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala Ala Ala Ser Glu
        435                 440                 445             
Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg
    450                 455                 460                 
Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala
465                 470                 475                 480 
Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His
                485                 490     


<210> 9107
<211> 382
<212> PRT
<213> Homo sapiens

<400> 9107
Gly Met Gly Met Ser Trp Asp Pro Ala Ser Asp Ser Ile Leu Gly Thr
 1               5                  10                  15      
Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Ala Ser Val Ile Ala Arg
            20                  25                  30          
Gly Lys Pro Val Thr Leu Trp Cys Gln Gly Pro Leu Glu Thr Glu Glu
        35                  40                  45              
Tyr Arg Leu Asp Lys Glu Gly Leu Pro Trp Ala Arg Lys Arg Gln Asn
    50                  55                  60                  
Pro Leu Glu Pro Gly Ala Lys Ala Lys Phe His Ile Pro Ser Thr Val
65                  70                  75                  80  
Tyr Asp Ser Ala Gly Arg Tyr Arg Cys Tyr Tyr Glu Thr Pro Ala Gly
                85                  90                  95      
Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Ala Thr Gly Val Ser
            100                 105                 110         
Arg Lys Pro Ser Leu Leu Ile Pro Gln Gly Ser Val Val Ala Arg Gly
        115                 120                 125             
Gly Ser Leu Thr Leu Gln Cys Arg Ser Asp Val Gly Tyr Asp Ile Phe
    130                 135                 140                 
Val Leu Tyr Lys Glu Gly Glu His Asp Leu Val Gln Gly Ser Gly Gln
145                 150                 155                 160 
Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val
                165                 170                 175     
Ser Arg Ser His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu
            180                 185                 190         
Ser Pro Arg Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala
        195                 200                 205             
Gly Leu Ile Pro Asp Ile Pro Ala Leu Ser Val Gln Pro Gly Pro Lys
    210                 215                 220                 
Val Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp His Gln
225                 230                 235                 240 
Ile Asp Thr Phe Phe Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu
                245                 250                 255     
Cys Leu Lys Ser Lys Tyr Gln Ser Tyr Arg His Gln Ala Glu Phe Ser
            260                 265                 270         
Met Ser Pro Val Thr Ser Ala Gln Gly Gly Thr Tyr Arg Cys Tyr Ser
        275                 280                 285             
Ala Ile Arg Ser Tyr Pro Tyr Leu Leu Ser Ser Pro Ser Tyr Pro Gln
    290                 295                 300                 
Glu Leu Val Val Ser Gly Glu Gly Pro Asp Pro Val Leu Ser Lys Leu
305                 310                 315                 320 
Lys Gly Ser Ala Gln Ala Leu Pro Pro Gly Glu Leu Trp Ala Gly Met
                325                 330                 335     
Glu Ser Arg Cys Gly Gly Glu Gly Leu Arg Gly Ala Gln Pro Glu Gly
            340                 345                 350         
Asp Ser Pro Leu Arg Gly Glu Glu Asp Asn Gly Gly Ser Pro Gly Met
        355                 360                 365             
Pro Thr Leu Gly Pro Ile Ser Trp Asp Ala Asn Gly Glu Arg
    370                 375                 380         


<210> 9108
<211> 1477
<212> PRT
<213> Homo sapiens

<400> 9108
Met Arg His Gly Val Ala Trp Ala Leu Leu Val Ala Ala Ala Leu Gly
 1               5                  10                  15      
Leu Gly Ala Arg Gly Val Arg Gly Ala Val Ala Leu Ala Asp Phe Tyr
            20                  25                  30          
Pro Phe Gly Ala Glu Arg Gly Asp Ala Val Thr Pro Lys Gln Asp Asp
        35                  40                  45              
Gly Gly Ser Gly Leu Arg Pro Leu Ser Val Pro Phe Pro Phe Phe Gly
    50                  55                  60                  
Ala Glu His Ser Gly Leu Tyr Ser Gly Gly Trp Pro Leu Arg Leu Arg
65                  70                  75                  80  
Leu Ser Lys Gln Asp Ser Gln Trp Asp Ser Trp Gly Gln Gly Leu Met
                85                  90                  95      
Thr Ala Gly Ser Ala Gln Leu Lys Glu Gln Ala Arg Val Pro Val Leu
            100                 105                 110         
Ser Pro Trp Leu Pro Glu Cys Asp Pro Arg Pro Ser Pro Tyr Gly Ser
        115                 120                 125             
Pro Gly Asn Glu Met His Leu Val Asn Asn Asn Gly Ile Ile Ser Phe
    130                 135                 140                 
Leu Lys Glu Val Ser Gln Phe Thr Pro Val Ala Phe Pro Ile Ala Lys
145                 150                 155                 160 
Asp Arg Cys Val Val Ala Ala Phe Trp Ala Asp Val Asp Asn Arg Arg
                165                 170                 175     
Ala Gly Asp Val Tyr Tyr Arg Glu Ala Thr Asp Pro Ala Met Leu Arg
            180                 185                 190         
Arg Ala Thr Glu Asp Val Arg His Tyr Phe Pro Glu Leu Leu Asp Phe
        195                 200                 205             
Asn Ala Thr Trp Val Phe Val Ala Thr Trp Tyr Arg Val Thr Phe Phe
    210                 215                 220                 
Gly Gly Ser Ser Ser Ser Pro Val Asn Thr Phe Gln Thr Val Leu Ile
225                 230                 235                 240 
Thr Asp Gly Lys Leu Ser Phe Thr Ile Phe Asn Tyr Glu Ser Ile Val
                245                 250                 255     
Trp Thr Thr Gly Thr His Ala Ser Ser Gly Gly Asn Ala Thr Gly Leu
            260                 265                 270         
Gly Gly Ile Ala Ala Gln Ala Gly Phe Asn Ala Gly Asp Gly Gln Arg
        275                 280                 285             
Tyr Phe Ser Ile Pro Gly Ser Arg Thr Ala Asp Met Ala Glu Val Glu
    290                 295                 300                 
Thr Thr Thr Asn Val Gly Val Pro Gly Arg Trp Ala Phe Arg Ile Asp
305                 310                 315                 320 
Asp Ala Gln Val Arg Val Gly Gly Cys Gly His Thr Thr Ser Val Cys
                325                 330                 335     
Leu Ala Leu Arg Pro Cys Leu Asn Gly Gly Lys Cys Ile Asp Asp Cys
            340                 345                 350         
Val Thr Gly Asn Pro Ser Tyr Thr Cys Ser Cys Leu Ser Gly Phe Thr
        355                 360                 365             
Gly Arg Arg Cys His Leu Asp Val Asn Glu Cys Ala Ser Gln Pro Cys
    370                 375                 380                 
Gln Asn Gly Gly Thr Cys Thr His Gly Ile Asn Ser Phe Arg Cys Gln
385                 390                 395                 400 
Cys Pro Ala Gly Phe Gly Gly Pro Thr Cys Glu Thr Ala Gln Ser Pro
                405                 410                 415     
Cys Asp Thr Lys Glu Cys Gln His Gly Gly Gln Cys Gln Val Glu Asn
            420                 425                 430         
Gly Ser Ala Val Cys Val Cys Gln Ala Gly Tyr Thr Gly Ala Ala Cys
        435                 440                 445             
Glu Met Asp Val Asp Asp Cys Ser Pro Asp Pro Cys Leu Asn Gly Gly
    450                 455                 460                 
Ser Cys Val Asp Leu Val Gly Asn Tyr Thr Cys Leu Cys Ala Glu Pro
465                 470                 475                 480 
Phe Lys Gly Leu Arg Cys Glu Thr Gly Asp His Pro Val Pro Asp Ala
                485                 490                 495     
Cys Leu Ser Ala Pro Cys His Asn Gly Gly Thr Cys Val Asp Ala Asp
            500                 505                 510         
Gln Gly Tyr Val Cys Glu Cys Pro Glu Gly Phe Met Gly Leu Asp Cys
        515                 520                 525             
Arg Glu Arg Val Pro Asp Asp Cys Glu Cys Arg Asn Gly Gly Arg Cys
    530                 535                 540                 
Leu Gly Ala Asn Thr Thr Leu Cys Gln Cys Pro Leu Gly Phe Phe Gly
545                 550                 555                 560 
Leu Leu Cys Glu Phe Glu Ile Thr Ala Met Pro Cys Asn Met Asn Thr
                565                 570                 575     
Gln Cys Pro Asp Gly Gly Tyr Cys Met Glu His Gly Gly Ser Tyr Leu
            580                 585                 590         
Cys Val Cys His Thr Asp His Asn Ala Ser His Ser Leu Pro Ser Pro
        595                 600                 605             
Cys Asp Ser Asp Pro Cys Phe Asn Gly Gly Ser Cys Asp Ala His Asp
    610                 615                 620                 
Asp Ser Tyr Thr Cys Glu Cys Pro Arg Gly Phe His Gly Lys His Cys
625                 630                 635                 640 
Glu Lys Ala Arg Pro His Leu Cys Ser Ser Gly Pro Cys Arg Asn Gly
                645                 650                 655     
Gly Thr Cys Lys Glu Ala Gly Gly Glu Tyr His Cys Ser Cys Pro Tyr
            660                 665                 670         
Arg Phe Thr Gly Arg His Cys Glu Ile Gly Lys Pro Asp Ser Cys Ala
        675                 680                 685             
Ser Gly Pro Cys His Asn Gly Gly Thr Cys Phe His Tyr Ile Gly Lys
    690                 695                 700                 
Tyr Lys Cys Asp Cys Pro Pro Gly Phe Ser Gly Arg His Cys Glu Ile
705                 710                 715                 720 
Ala Pro Ser Pro Cys Phe Arg Ser Pro Cys Val Asn Gly Gly Thr Cys
                725                 730                 735     
Glu Asp Arg Asp Thr Asp Phe Phe Cys His Cys Gln Ala Gly Tyr Met
            740                 745                 750         
Gly Arg Arg Cys Gln Ala Glu Val Asp Cys Gly Pro Pro Glu Glu Val
        755                 760                 765             
Lys His Ala Thr Leu Arg Phe Asn Gly Thr Arg Leu Gly Ala Val Ala
    770                 775                 780                 
Leu Tyr Ala Cys Asp Arg Gly Tyr Ser Leu Ser Ala Pro Ser Arg Ile
785                 790                 795                 800 
Arg Val Cys Gln Pro His Gly Val Trp Ser Glu Pro Pro Gln Cys Leu
                805                 810                 815     
Glu Ile Asp Glu Cys Arg Ser Gln Pro Cys Leu His Gly Gly Ser Cys
            820                 825                 830         
Gln Asp Arg Val Ala Gly Tyr Leu Cys Leu Cys Ser Thr Gly Tyr Glu
        835                 840                 845             
Gly Ala His Cys Glu Leu Glu Arg Asp Glu Cys Arg Ala His Pro Cys
    850                 855                 860                 
Arg Asn Gly Gly Ser Cys Arg Asn Leu Pro Gly Ala Tyr Val Cys Arg
865                 870                 875                 880 
Cys Pro Ala Gly Phe Val Gly Val His Cys Glu Thr Glu Val Asp Ala
                885                 890                 895     
Cys Asp Ser Ser Pro Cys Gln His Gly Gly Arg Cys Glu Ser Gly Gly
            900                 905                 910         
Gly Ala Tyr Leu Cys Val Cys Pro Glu Ser Phe Phe Gly Tyr His Cys
        915                 920                 925             
Glu Thr Val Ser Asp Pro Cys Phe Ser Ser Pro Cys Gly Gly Arg Gly
    930                 935                 940                 
Tyr Cys Leu Ala Ser Asn Gly Ser His Ser Cys Thr Cys Lys Val Gly
945                 950                 955                 960 
Tyr Thr Gly Glu Asp Cys Ala Lys Glu Leu Phe Pro Pro Thr Ala Leu
                965                 970                 975     
Lys Met Glu Arg Val Glu Glu Ser Gly Val Ser Ile Ser Trp Asn Pro
            980                 985                 990         
Pro Asn Gly Pro Ala Ala Arg Gln Met Leu Asp Gly Tyr Ala Val Thr
        995                 1000                1005            
Tyr Val Ser Ser Asp Gly Ser Tyr Arg Arg Thr Asp Phe Val Asp Arg
    1010                1015                1020                
Thr Arg Ser Ser His Gln Leu Gln Ala Leu Ala Ala Gly Arg Ala Tyr
1025                1030                1035                1040
Asn Ile Ser Val Phe Ser Val Lys Arg Asn Ser Asn Asn Lys Asn Asp
                1045                1050                1055    
Ile Ser Arg Pro Ala Val Leu Leu Ala Arg Thr Arg Pro Arg Pro Val
            1060                1065                1070        
Glu Gly Phe Glu Val Thr Asn Val Thr Ala Ser Thr Ile Ser Val Gln
        1075                1080                1085            
Trp Ala Leu His Arg Ile Arg His Ala Thr Val Ser Gly Val Arg Val
    1090                1095                1100                
Ser Ile Arg His Pro Glu Ala Leu Arg Asp Gln Ala Thr Asp Val Asp
1105                1110                1115                1120
Arg Ser Val Asp Arg Phe Thr Phe Arg Ala Leu Leu Pro Gly Lys Arg
                1125                1130                1135    
Tyr Thr Ile Gln Leu Thr Thr Leu Ser Gly Leu Arg Gly Glu Glu His
            1140                1145                1150        
Pro Thr Glu Ser Leu Ala Thr Ala Pro Thr His Val Trp Thr Arg Pro
        1155                1160                1165            
Leu Pro Pro Ala Asn Leu Thr Ala Ala Arg Val Thr Ala Thr Ser Ala
    1170                1175                1180                
His Val Val Trp Asp Ala Pro Thr Pro Gly Ser Leu Leu Glu Ala Tyr
1185                1190                1195                1200
Val Ile Asn Val Thr Thr Ser Gln Ser Thr Lys Ser Arg Tyr Val Pro
                1205                1210                1215    
Asn Gly Lys Leu Ala Ser Tyr Thr Val Arg Asp Leu Leu Pro Gly Arg
            1220                1225                1230        
Arg Tyr Gln Leu Ser Val Ile Ala Val Gln Ser Thr Glu Leu Gly Pro
        1235                1240                1245            
Gln His Ser Glu Pro Ala His Leu Tyr Ile Ile Thr Ser Pro Arg Asp
    1250                1255                1260                
Gly Ala Asp Arg Arg Trp His Gln Gly Gly His His Pro Arg Val Leu
1265                1270                1275                1280
Lys Asn Arg Pro Pro Pro Ala Arg Leu Pro Glu Leu Arg Leu Leu Asn
                1285                1290                1295    
Asp His Ser Ala Pro Glu Thr Pro Thr Gln Pro Pro Arg Phe Ser Glu
            1300                1305                1310        
Leu Val Asp Gly Arg Gly Arg Val Ser Ala Arg Phe Gly Gly Ser Pro
        1315                1320                1325            
Ser Lys Ala Ala Thr Val Arg Ser Gln Pro Thr Ala Ser Ala Gln Leu
    1330                1335                1340                
Glu Asn Met Glu Glu Ala Pro Lys Arg Val Ser Leu Ala Leu Gln Leu
1345                1350                1355                1360
Pro Glu His Gly Ser Lys Asp Ile Gly Asn Val Pro Gly Asn Cys Ser
                1365                1370                1375    
Glu Asn Pro Cys Gln Asn Gly Gly Thr Cys Val Pro Gly Ala Asp Ala
            1380                1385                1390        
His Ser Cys Asp Cys Gly Pro Gly Phe Lys Gly Arg Arg Cys Glu Leu
        1395                1400                1405            
Ala Cys Ile Lys Val Ser Arg Pro Cys Thr Arg Leu Phe Ser Glu Thr
    1410                1415                1420                
Lys Ala Phe Pro Val Trp Glu Gly Gly Val Cys His His Val Tyr Lys
1425                1430                1435                1440
Arg Val Tyr Arg Val His Gln Asp Ile Cys Phe Lys Glu Ser Cys Glu
                1445                1450                1455    
Ser Thr Ser Leu Lys Lys Thr Pro Asn Arg Lys Gln Ser Lys Ser Gln
            1460                1465                1470        
Thr Leu Glu Lys Ser
        1475        


<210> 9109
<211> 424
<212> PRT
<213> Homo sapiens

<400> 9109
Met Gln Arg Leu Gln Val Val Leu Gly His Leu Arg Gly Pro Ala Asp
 1               5                  10                  15      
Ser Gly Trp Met Pro Gln Ala Ala Pro Cys Leu Ser Gly Ala Pro Gln
            20                  25                  30          
Ala Ser Ala Ala Asp Val Val Val Val His Gly Arg Arg Thr Ala Ile
        35                  40                  45              
Cys Arg Ala Gly Arg Gly Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu
    50                  55                  60                  
Leu Ser Ala Val Met Thr Ala Val Leu Lys Asp Val Asn Leu Arg Pro
65                  70                  75                  80  
Glu Gln Leu Gly Asp Ile Cys Val Gly Asn Val Leu Gln Pro Gly Ala
                85                  90                  95      
Gly Ala Ile Met Ala Arg Ile Ala Gln Phe Leu Ser Asp Ile Pro Glu
            100                 105                 110         
Thr Val Pro Leu Ser Thr Val Asn Arg Gln Cys Ser Ser Gly Leu Gln
        115                 120                 125             
Ala Val Ala Ser Ile Ala Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile
    130                 135                 140                 
Gly Met Ala Cys Gly Val Glu Ser Met Ser Leu Ala Asp Arg Gly Asn
145                 150                 155                 160 
Pro Gly Asn Ile Thr Ser Arg Leu Met Glu Lys Glu Lys Ala Arg Asp
                165                 170                 175     
Cys Leu Ile Pro Met Gly Ile Thr Ser Glu Asn Val Ala Glu Arg Phe
            180                 185                 190         
Gly Ile Ser Arg Glu Lys Gln Asp Thr Phe Ala Leu Ala Ser Gln Gln
        195                 200                 205             
Lys Ala Ala Arg Ala Gln Ser Lys Gly Cys Phe Gln Ala Glu Ile Val
    210                 215                 220                 
Pro Val Thr Thr Thr Val His Asp Asp Lys Gly Thr Lys Arg Ser Ile
225                 230                 235                 240 
Thr Val Thr Gln Asp Glu Gly Ile Arg Pro Ser Thr Thr Met Glu Gly
                245                 250                 255     
Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Ser Thr Thr Ala
            260                 265                 270         
Gly Asn Ser Ser Gln Val Ser Asp Gly Ala Ala Ala Ile Leu Leu Ala
        275                 280                 285             
Arg Arg Ser Lys Ala Glu Glu Leu Gly Leu Pro Ile Leu Gly Val Leu
    290                 295                 300                 
Arg Ser Tyr Ala Val Val Gly Val Pro Pro Asp Ile Met Gly Ile Gly
305                 310                 315                 320 
Pro Ala Tyr Ala Ile Pro Val Ala Leu Gln Lys Ala Gly Leu Thr Val
                325                 330                 335     
Ser Asp Val Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala Ser Gln Ala
            340                 345                 350         
Ala Tyr Cys Val Glu Lys Leu Arg Leu Pro Pro Glu Lys Val Asn Pro
        355                 360                 365             
Leu Gly Gly Ala Val Ala Leu Gly His Pro Leu Gly Cys Thr Gly Ala
    370                 375                 380                 
Arg Gln Val Ile Thr Leu Leu Asn Glu Leu Lys Arg Arg Gly Lys Arg
385                 390                 395                 400 
Ala Tyr Gly Val Val Ser Met Cys Ile Gly Thr Gly Met Gly Ala Ala
                405                 410                 415     
Ala Val Phe Glu Tyr Pro Gly Asn
            420                 


<210> 9110
<211> 719
<212> PRT
<213> Homo sapiens

<400> 9110
Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys
 1               5                  10                  15      
Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn
            20                  25                  30          
Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn
        35                  40                  45              
Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr
    50                  55                  60                  
Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu
65                  70                  75                  80  
Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala
                85                  90                  95      
Asp Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr
            100                 105                 110         
Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu
        115                 120                 125             
Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp
    130                 135                 140                 
Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu
145                 150                 155                 160 
Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu
                165                 170                 175     
Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser
            180                 185                 190         
His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln
        195                 200                 205             
Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr
    210                 215                 220                 
Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn
225                 230                 235                 240 
Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg
                245                 250                 255     
Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg
            260                 265                 270         
Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu
        275                 280                 285             
Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala
    290                 295                 300                 
Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp
305                 310                 315                 320 
Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val
                325                 330                 335     
Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr
            340                 345                 350         
Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln
        355                 360                 365             
Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr
    370                 375                 380                 
Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser
385                 390                 395                 400 
Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu
                405                 410                 415     
Ser Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu
            420                 425                 430         
Leu Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln
        435                 440                 445             
Ile Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Met Ile
    450                 455                 460                 
Pro Pro Thr Ser Lys Thr Phe Leu Val Asn Asn Leu Ala Ala Gly Thr
465                 470                 475                 480 
Met Tyr Asp Leu Cys Val Leu Ala Ile Tyr Asp Asp Gly Ile Thr Ser
                485                 490                 495     
Leu Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe Thr Thr Glu Gln
            500                 505                 510         
Asp Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe Leu Gly Gly Thr
        515                 520                 525             
Met Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser Val Leu Val Phe
    530                 535                 540                 
Ile Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn Asn Asn Gly Gln
545                 550                 555                 560 
His Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln Thr Asn Gly Ala
                565                 570                 575     
Gln Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser Val Ser Lys Gln
            580                 585                 590         
Ala Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys Ala Thr Ser Asp
        595                 600                 605             
Asn Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln Asp Ser Ser Thr
    610                 615                 620                 
Thr Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser Thr Ser Val Ser
625                 630                 635                 640 
Gln Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser Thr Glu Pro Gln
                645                 650                 655     
Asn Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr Asn Arg Asn Asn
            660                 665                 670         
Ser Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp Ser Val Thr Glu
        675                 680                 685             
Gly Pro Thr Ser Lys Arg Ala His Ile Lys Pro Asn Ala Leu Leu Thr
    690                 695                 700                 
Asn Val Asp Gln Ile Val Gln Glu Thr Gln Arg Leu Glu Leu Ile
705                 710                 715                 


<210> 9111
<211> 236
<212> PRT
<213> Homo sapiens

<400> 9111
Met Thr Ala Glu Phe Leu Ser Leu Leu Cys Leu Gly Leu Cys Leu Gly
 1               5                  10                  15      
Tyr Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His
            20                  25                  30          
Ala Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys
        35                  40                  45              
Cys Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn
    50                  55                  60                  
Asp Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu
65                  70                  75                  80  
Phe Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys
                85                  90                  95      
Ala Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His
            100                 105                 110         
Leu Gln Leu Val Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro Ser
        115                 120                 125             
Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys Ile
    130                 135                 140                 
Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys Ser
145                 150                 155                 160 
Gln His Gly Ser Ser Ser Glu Glu Ser Thr Lys Arg Thr Ser His Ser
                165                 170                 175     
Lys Leu Pro Glu Gln Glu Ala Ala Glu Ala Asp Leu Ser Asn Met Glu
            180                 185                 190         
Arg Val Ser Leu Ser Thr Ala Asp Pro Gln Gly Val Thr Tyr Ala Glu
        195                 200                 205             
Leu Ser Thr Ser Ala Leu Ser Glu Ala Ala Ser Asp Thr Thr Gln Glu
    210                 215                 220                 
Pro Pro Gly Ser His Glu Tyr Ala Ala Leu Lys Val
225                 230                 235     


<210> 9112
<211> 236
<212> PRT
<213> Homo sapiens

<400> 9112
Met Thr Ala Glu Phe Leu Ser Leu Leu Cys Leu Gly Leu Cys Leu Gly
 1               5                  10                  15      
Tyr Glu Asp Glu Lys Lys Asn Glu Lys Pro Pro Lys Pro Ser Leu His
            20                  25                  30          
Ala Trp Pro Ser Ser Val Val Glu Ala Glu Ser Asn Val Thr Leu Lys
        35                  40                  45              
Cys Gln Ala His Ser Gln Asn Val Thr Phe Val Leu Arg Lys Val Asn
    50                  55                  60                  
Asp Ser Gly Tyr Lys Gln Glu Gln Ser Ser Ala Glu Asn Glu Ala Glu
65                  70                  75                  80  
Phe Pro Phe Thr Asp Leu Lys Pro Lys Asp Ala Gly Arg Tyr Phe Cys
                85                  90                  95      
Ala Tyr Lys Thr Thr Ala Ser His Glu Trp Ser Glu Ser Ser Glu His
            100                 105                 110         
Leu Gln Leu Val Val Thr Asp Lys His Asp Glu Leu Glu Ala Pro Ser
        115                 120                 125             
Met Lys Thr Asp Thr Arg Thr Ile Phe Val Ala Ile Phe Ser Cys Ile
    130                 135                 140                 
Ser Ile Leu Leu Leu Phe Leu Ser Val Phe Ile Ile Tyr Arg Cys Ser
145                 150                 155                 160 
Gln His Ser Ser Ser Ser Glu Glu Ser Thr Lys Arg Thr Ser His Ser
                165                 170                 175     
Lys Leu Pro Glu Gln Glu Ala Ala Glu Ala Asp Leu Ser Asn Met Glu
            180                 185                 190         
Arg Val Ser Leu Ser Thr Ala Asp Pro Gln Gly Val Thr Tyr Ala Glu
        195                 200                 205             
Leu Ser Thr Ser Ala Leu Ser Glu Ala Ala Ser Asp Thr Thr Gln Glu
    210                 215                 220                 
Pro Pro Gly Ser His Glu Tyr Ala Ala Leu Lys Val
225                 230                 235     


<210> 9113
<211> 978
<212> PRT
<213> Homo sapiens

<400> 9113
Met Leu Leu Trp Val Ile Leu Leu Val Leu Asp Ser Phe Ser Leu Ser
 1               5                  10                  15      
Ser Ser Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp
            20                  25                  30          
Thr Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe
        35                  40                  45              
Arg Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly
    50                  55                  60                  
Lys Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu
65                  70                  75                  80  
Ser Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro
                85                  90                  95      
Val His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu
            100                 105                 110         
Ser Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala
        115                 120                 125             
Glu Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala
    130                 135                 140                 
Phe Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys
145                 150                 155                 160 
Asp Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro
                165                 170                 175     
Val Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg
            180                 185                 190         
Pro Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val
        195                 200                 205             
Thr Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro
    210                 215                 220                 
Leu Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp
225                 230                 235                 240 
Ser Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser
                245                 250                 255     
Gly Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser
            260                 265                 270         
Asp Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro
        275                 280                 285             
Val Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys
    290                 295                 300                 
Val Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr
305                 310                 315                 320 
Arg Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys
                325                 330                 335     
Glu Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly
            340                 345                 350         
Asn Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys
        355                 360                 365             
Ala Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn
    370                 375                 380                 
Leu Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu
385                 390                 395                 400 
His Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His
                405                 410                 415     
His Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly
            420                 425                 430         
Val Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr
        435                 440                 445             
Cys Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser
    450                 455                 460                 
Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser
465                 470                 475                 480 
Ala Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu
                485                 490                 495     
Val Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp
            500                 505                 510         
Met Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe
        515                 520                 525             
Ser Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala
    530                 535                 540                 
Asp Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val
545                 550                 555                 560 
Thr Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala
                565                 570                 575     
Gln Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg
            580                 585                 590         
Gly Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu
        595                 600                 605             
Gly Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser
    610                 615                 620                 
Leu Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly
625                 630                 635                 640 
Leu Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro
                645                 650                 655     
Val Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val
            660                 665                 670         
Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser
        675                 680                 685             
Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile
    690                 695                 700                 
Ser Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr
705                 710                 715                 720 
Glu His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala
                725                 730                 735     
Gln Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg
            740                 745                 750         
Pro Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp
        755                 760                 765             
Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu
    770                 775                 780                 
Tyr Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro
785                 790                 795                 800 
Ser Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly
                805                 810                 815     
Asn Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu
            820                 825                 830         
Thr Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro
        835                 840                 845             
Phe Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala
    850                 855                 860                 
Ala Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg
865                 870                 875                 880 
Lys Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln
                885                 890                 895     
Glu Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val
            900                 905                 910         
Tyr Thr Asn Ala Asn Pro Arg Gly Glu Asn Val Val Tyr Ser Glu Val
        915                 920                 925             
Arg Ile Ile Gln Glu Lys Lys Lys His Ala Val Ala Ser Asp Pro Arg
    930                 935                 940                 
His Leu Arg Asn Lys Gly Ser Pro Ile Ile Tyr Ser Glu Val Lys Val
945                 950                 955                 960 
Ala Ser Thr Pro Val Ser Gly Ser Leu Phe Leu Ala Ser Ser Ala Pro
                965                 970                 975     
His Arg
        


<210> 9114
<211> 400
<212> PRT
<213> Homo sapiens

<400> 9114
Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu
 1               5                  10                  15      
Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val
            20                  25                  30          
Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr
        35                  40                  45              
Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly
    50                  55                  60                  
Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala
65                  70                  75                  80  
Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg
                85                  90                  95      
Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser
            100                 105                 110         
Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val
        115                 120                 125             
Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser
    130                 135                 140                 
Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg
145                 150                 155                 160 
Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro
                165                 170                 175     
Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala
            180                 185                 190         
Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly
        195                 200                 205             
Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr
    210                 215                 220                 
Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala
225                 230                 235                 240 
Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln
                245                 250                 255     
Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val
            260                 265                 270         
Val Ile Gln Pro Thr Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser
        275                 280                 285             
Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp
    290                 295                 300                 
Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met
305                 310                 315                 320 
Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg
                325                 330                 335     
Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp
            340                 345                 350         
Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser
        355                 360                 365             
Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg
    370                 375                 380                 
Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly
385                 390                 395                 400 


<210> 9115
<211> 111
<212> PRT
<213> Homo sapiens

<400> 9115
Met Val Pro Val Leu Leu Ser Leu Leu His Leu Leu Gly Pro Ala Ile
 1               5                  10                  15      
Pro Gln Glu Thr Gln Asp Gly His Tyr Ser Leu Thr Tyr Leu Tyr Thr
            20                  25                  30          
Gly Leu Ser Arg Pro Gly Lys Gly Thr His Arg Leu Gln Gly Thr Val
        35                  40                  45              
Phe Leu Asn Gly Arg Ala Phe Phe His Tyr Asn Ser Glu Asp Arg Lys
    50                  55                  60                  
Pro Glu Pro Leu Gly Pro Trp Arg His Val Glu Gly Val Glu Asp Trp
65                  70                  75                  80  
Glu Lys Gln Ser Gln Val Gln Lys Ala Arg Glu Asp Ile Phe Met Glu
                85                  90                  95      
Thr Leu Asn Asn Ile Met Glu Tyr Tyr Asn Asp Ser Asn Gly Gln
            100                 105                 110     


<210> 9116
<211> 2489
<212> PRT
<213> Homo sapiens

<400> 9116
Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala
 1               5                  10                  15      
Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val
            20                  25                  30          
Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp
        35                  40                  45              
Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro
    50                  55                  60                  
Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg
65                  70                  75                  80  
Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys
                85                  90                  95      
Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn
            100                 105                 110         
Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys
        115                 120                 125             
Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr
    130                 135                 140                 
Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile
145                 150                 155                 160 
Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp
                165                 170                 175     
Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr
            180                 185                 190         
Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val
        195                 200                 205             
Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile
    210                 215                 220                 
Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro
225                 230                 235                 240 
Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe
                245                 250                 255     
Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met
            260                 265                 270         
Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro
        275                 280                 285             
Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu
    290                 295                 300                 
His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln
305                 310                 315                 320 
Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala
                325                 330                 335     
Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr
            340                 345                 350         
Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly
        355                 360                 365             
Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe
    370                 375                 380                 
Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys
385                 390                 395                 400 
Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys
                405                 410                 415     
Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His
            420                 425                 430         
Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr
        435                 440                 445             
Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly
    450                 455                 460                 
Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp
465                 470                 475                 480 
Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro
                485                 490                 495     
Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp
            500                 505                 510         
Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr
        515                 520                 525             
Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser
    530                 535                 540                 
Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro
545                 550                 555                 560 
Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg
                565                 570                 575     
Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser
            580                 585                 590         
Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro
        595                 600                 605             
Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn
    610                 615                 620                 
Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val
625                 630                 635                 640 
Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu
                645                 650                 655     
Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val
            660                 665                 670         
Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys
        675                 680                 685             
Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser
    690                 695                 700                 
Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe
705                 710                 715                 720 
Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp
                725                 730                 735     
Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp
            740                 745                 750         
Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro
        755                 760                 765             
Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly
    770                 775                 780                 
Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala
785                 790                 795                 800 
Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu
                805                 810                 815     
Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val
            820                 825                 830         
Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser
        835                 840                 845             
Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro
    850                 855                 860                 
Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly
865                 870                 875                 880 
Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val
                885                 890                 895     
Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu
            900                 905                 910         
Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly
        915                 920                 925             
Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln
    930                 935                 940                 
Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala
945                 950                 955                 960 
Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu
                965                 970                 975     
Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp
            980                 985                 990         
Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro
        995                 1000                1005            
Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly
    1010                1015                1020                
Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His
1025                1030                1035                1040
Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr
                1045                1050                1055    
Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile
            1060                1065                1070        
Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly
        1075                1080                1085            
Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val
    1090                1095                1100                
Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp
1105                1110                1115                1120
Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn
                1125                1130                1135    
Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn
            1140                1145                1150        
Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro
        1155                1160                1165            
Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn
    1170                1175                1180                
Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro
1185                1190                1195                1200
Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe
                1205                1210                1215    
Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu
            1220                1225                1230        
Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro
        1235                1240                1245            
Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln
    1250                1255                1260                
Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala
1265                1270                1275                1280
Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser
                1285                1290                1295    
Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser
            1300                1305                1310        
Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro
        1315                1320                1325            
Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys
    1330                1335                1340                
Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe
1345                1350                1355                1360
Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly
                1365                1370                1375    
Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His
            1380                1385                1390        
Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr
        1395                1400                1405            
Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg
    1410                1415                1420                
Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu
1425                1430                1435                1440
Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr
                1445                1450                1455    
Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln
            1460                1465                1470        
Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile
        1475                1480                1485            
Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp
    1490                1495                1500                
Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro
1505                1510                1515                1520
Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His
                1525                1530                1535    
Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly Arg
            1540                1545                1550        
Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn
        1555                1560                1565            
Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile
    1570                1575                1580                
Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser
1585                1590                1595                1600
Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys
                1605                1610                1615    
Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala
            1620                1625                1630        
Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln
        1635                1640                1645            
Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Pro Ser His Gln Asp
    1650                1655                1660                
Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr
1665                1670                1675                1680
Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp
                1685                1690                1695    
Ser Pro Glu Ala Pro Arg Cys Ala Val Lys Ser Cys Asp Asp Phe Leu
            1700                1705                1710        
Gly Gln Leu Pro His Gly Arg Val Leu Phe Pro Leu Asn Leu Gln Leu
        1715                1720                1725            
Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly
    1730                1735                1740                
Ser Ser Val Ser His Cys Val Leu Val Gly Met Arg Ser Leu Trp Asn
1745                1750                1755                1760
Asn Ser Val Pro Val Cys Glu His Ile Phe Cys Pro Asn Pro Pro Ala
                1765                1770                1775    
Ile Leu Asn Gly Arg His Thr Gly Thr Pro Ser Gly Asp Ile Pro Tyr
            1780                1785                1790        
Gly Lys Glu Ile Ser Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met
        1795                1800                1805            
Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro
    1810                1815                1820                
His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Ser
1825                1830                1835                1840
Val Arg Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala Ser
                1845                1850                1855    
Pro Thr Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser Leu
            1860                1865                1870        
Asn Tyr Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile Ser
        1875                1880                1885            
Cys Leu Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg Arg
    1890                1895                1900                
Lys Ser Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His Ile
1905                1910                1915                1920
Asn Thr Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn Glu
                1925                1930                1935    
Gly Phe Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser Gly
            1940                1945                1950        
Asn Asn Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile Ser
        1955                1960                1965            
Cys Glu Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn Asn
    1970                1975                1980                
Arg Thr Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His Thr
1985                1990                1995                2000
Gly Pro Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser Ile
                2005                2010                2015    
Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro Pro
            2020                2025                2030        
Pro Arg Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu Asn
        2035                2040                2045            
Ala Ile Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu Ile
    2050                2055                2060                
Val Arg Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His Thr
2065                2070                2075                2080
Val Gln Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His Cys
                2085                2090                2095    
Ser Arg Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr
            2100                2105                2110        
Leu Ser His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser
        2115                2120                2125            
Cys Glu Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr
    2130                2135                2140                
Pro Gln Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys Ser
2145                2150                2155                2160
Cys Asp Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu Pro
                2165                2170                2175    
Leu Asn Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly
            2180                2185                2190        
Phe Arg Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met
        2195                2200                2205            
Lys Ala Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys
    2210                2215                2220                
Pro Asn Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Phe
2225                2230                2235                2240
Gly Asp Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr His
                2245                2250                2255    
Pro Asp Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg
            2260                2265                2270        
Cys Thr Ser Asp Arg Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro
        2275                2280                2285            
Arg Cys Glu Leu Ser Val Pro Ala Ala Cys Pro Asp Pro Pro Lys Ile
    2290                2295                2300                
Gln Asn Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly
2305                2310                2315                2320
Met Thr Ile Ser Tyr Ile Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys
                2325                2330                2335    
Gly Phe Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp His
            2340                2345                2350        
Tyr Cys Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile
        2355                2360                2365            
Ser Lys Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val
    2370                2375                2380                
Thr Leu Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp Ser
2385                2390                2395                2400
Gln Cys Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Thr
                2405                2410                2415    
Ser Arg Ala His Asp Ala Leu Ile Val Gly Thr Leu Ser Gly Thr Ile
            2420                2425                2430        
Phe Phe Ile Leu Leu Ile Ile Phe Leu Ser Trp Ile Ile Leu Lys His
        2435                2440                2445            
Arg Lys Gly Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala Ile His
    2450                2455                2460                
Leu His Ser Gln Gly Gly Ser Ser Val His Pro Arg Thr Leu Gln Thr
2465                2470                2475                2480
Asn Glu Glu Asn Ser Arg Val Leu Pro
                2485                


<210> 9117
<211> 2039
<212> PRT
<213> Homo sapiens

<400> 9117
Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala
 1               5                  10                  15      
Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val
            20                  25                  30          
Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp
        35                  40                  45              
Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro
    50                  55                  60                  
Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg
65                  70                  75                  80  
Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys
                85                  90                  95      
Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn
            100                 105                 110         
Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys
        115                 120                 125             
Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr
    130                 135                 140                 
Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile
145                 150                 155                 160 
Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp
                165                 170                 175     
Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr
            180                 185                 190         
Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val
        195                 200                 205             
Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile
    210                 215                 220                 
Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro
225                 230                 235                 240 
Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe
                245                 250                 255     
Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met
            260                 265                 270         
Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro
        275                 280                 285             
Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu
    290                 295                 300                 
His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln
305                 310                 315                 320 
Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala
                325                 330                 335     
Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr
            340                 345                 350         
Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly
        355                 360                 365             
Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe
    370                 375                 380                 
Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys
385                 390                 395                 400 
Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys
                405                 410                 415     
Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His
            420                 425                 430         
Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr
        435                 440                 445             
Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly
    450                 455                 460                 
Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp
465                 470                 475                 480 
Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro
                485                 490                 495     
Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp
            500                 505                 510         
Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr
        515                 520                 525             
Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser
    530                 535                 540                 
Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro
545                 550                 555                 560 
Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg
                565                 570                 575     
Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser
            580                 585                 590         
Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro
        595                 600                 605             
Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn
    610                 615                 620                 
Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val
625                 630                 635                 640 
Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu
                645                 650                 655     
Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val
            660                 665                 670         
Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys
        675                 680                 685             
Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser
    690                 695                 700                 
Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe
705                 710                 715                 720 
Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp
                725                 730                 735     
Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp
            740                 745                 750         
Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro
        755                 760                 765             
Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly
    770                 775                 780                 
Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala
785                 790                 795                 800 
Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu
                805                 810                 815     
Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val
            820                 825                 830         
Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser
        835                 840                 845             
Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro
    850                 855                 860                 
Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly
865                 870                 875                 880 
Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val
                885                 890                 895     
Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu
            900                 905                 910         
Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly
        915                 920                 925             
Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln
    930                 935                 940                 
Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala
945                 950                 955                 960 
Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu
                965                 970                 975     
Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp
            980                 985                 990         
Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro
        995                 1000                1005            
Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly
    1010                1015                1020                
Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His
1025                1030                1035                1040
Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser Thr
                1045                1050                1055    
Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile
            1060                1065                1070        
Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly
        1075                1080                1085            
Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly Arg Lys Val
    1090                1095                1100                
Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp
1105                1110                1115                1120
Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn
                1125                1130                1135    
Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn
            1140                1145                1150        
Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro
        1155                1160                1165            
Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn
    1170                1175                1180                
Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro
1185                1190                1195                1200
Pro Glu Ile Leu His Gly Glu His Thr Pro Ser His Gln Asp Asn Phe
                1205                1210                1215    
Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu
            1220                1225                1230        
Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro
        1235                1240                1245            
Glu Ala Pro Arg Cys Ala Val Lys Ser Cys Asp Asp Phe Leu Gly Gln
    1250                1255                1260                
Leu Pro His Gly Arg Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala
1265                1270                1275                1280
Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg Leu Lys Gly Ser Ser
                1285                1290                1295    
Val Ser His Cys Val Leu Val Gly Met Arg Ser Leu Trp Asn Asn Ser
            1300                1305                1310        
Val Pro Val Cys Glu His Ile Phe Cys Pro Asn Pro Pro Ala Ile Leu
        1315                1320                1325            
Asn Gly Arg His Thr Gly Thr Pro Ser Gly Asp Ile Pro Tyr Gly Lys
    1330                1335                1340                
Glu Ile Ser Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met Thr Phe
1345                1350                1355                1360
Asn Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro His Gly
                1365                1370                1375    
Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Ser Val Arg
            1380                1385                1390        
Ala Gly His Cys Lys Thr Pro Glu Gln Phe Pro Phe Ala Ser Pro Thr
        1395                1400                1405            
Ile Pro Ile Asn Asp Phe Glu Phe Pro Val Gly Thr Ser Leu Asn Tyr
    1410                1415                1420                
Glu Cys Arg Pro Gly Tyr Phe Gly Lys Met Phe Ser Ile Ser Cys Leu
1425                1430                1435                1440
Glu Asn Leu Val Trp Ser Ser Val Glu Asp Asn Cys Arg Arg Lys Ser
                1445                1450                1455    
Cys Gly Pro Pro Pro Glu Pro Phe Asn Gly Met Val His Ile Asn Thr
            1460                1465                1470        
Asp Thr Gln Phe Gly Ser Thr Val Asn Tyr Ser Cys Asn Glu Gly Phe
        1475                1480                1485            
Arg Leu Ile Gly Ser Pro Ser Thr Thr Cys Leu Val Ser Gly Asn Asn
    1490                1495                1500                
Val Thr Trp Asp Lys Lys Ala Pro Ile Cys Glu Ile Ile Ser Cys Glu
1505                1510                1515                1520
Pro Pro Pro Thr Ile Ser Asn Gly Asp Phe Tyr Ser Asn Asn Arg Thr
                1525                1530                1535    
Ser Phe His Asn Gly Thr Val Val Thr Tyr Gln Cys His Thr Gly Pro
            1540                1545                1550        
Asp Gly Glu Gln Leu Phe Glu Leu Val Gly Glu Arg Ser Ile Tyr Cys
        1555                1560                1565            
Thr Ser Lys Asp Asp Gln Val Gly Val Trp Ser Ser Pro Pro Pro Arg
    1570                1575                1580                
Cys Ile Ser Thr Asn Lys Cys Thr Ala Pro Glu Val Glu Asn Ala Ile
1585                1590                1595                1600
Arg Val Pro Gly Asn Arg Ser Phe Phe Ser Leu Thr Glu Ile Ile Arg
                1605                1610                1615    
Phe Arg Cys Gln Pro Gly Phe Val Met Val Gly Ser His Thr Val Gln
            1620                1625                1630        
Cys Gln Thr Asn Gly Arg Trp Gly Pro Lys Leu Pro His Cys Ser Arg
        1635                1640                1645            
Val Cys Gln Pro Pro Pro Glu Ile Leu His Gly Glu His Thr Leu Ser
    1650                1655                1660                
His Gln Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu
1665                1670                1675                1680
Pro Ser Tyr Asp Leu Arg Gly Ala Ala Ser Leu His Cys Thr Pro Gln
                1685                1690                1695    
Gly Asp Trp Ser Pro Glu Ala Pro Arg Cys Thr Val Lys Ser Cys Asp
            1700                1705                1710        
Asp Phe Leu Gly Gln Leu Pro His Gly Arg Val Leu Leu Pro Leu Asn
        1715                1720                1725            
Leu Gln Leu Gly Ala Lys Val Ser Phe Val Cys Asp Glu Gly Phe Arg
    1730                1735                1740                
Leu Lys Gly Arg Ser Ala Ser His Cys Val Leu Ala Gly Met Lys Ala
1745                1750                1755                1760
Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Asn
                1765                1770                1775    
Pro Pro Ala Ile Leu Asn Gly Arg His Thr Gly Thr Pro Phe Gly Asp
            1780                1785                1790        
Ile Pro Tyr Gly Lys Glu Ile Ser Tyr Ala Cys Asp Thr His Pro Asp
        1795                1800                1805            
Arg Gly Met Thr Phe Asn Leu Ile Gly Glu Ser Ser Ile Arg Cys Thr
    1810                1815                1820                
Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys
1825                1830                1835                1840
Glu Leu Ser Val Pro Ala Ala Cys Pro His Pro Pro Lys Ile Gln Asn
                1845                1850                1855    
Gly His Tyr Ile Gly Gly His Val Ser Leu Tyr Leu Pro Gly Met Thr
            1860                1865                1870        
Ile Ser Tyr Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Lys Gly Phe
        1875                1880                1885            
Ile Phe Cys Thr Asp Gln Gly Ile Trp Ser Gln Leu Asp His Tyr Cys
    1890                1895                1900                
Lys Glu Val Asn Cys Ser Phe Pro Leu Phe Met Asn Gly Ile Ser Lys
1905                1910                1915                1920
Glu Leu Glu Met Lys Lys Val Tyr His Tyr Gly Asp Tyr Val Thr Leu
                1925                1930                1935    
Lys Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Trp Ser Gln Cys
            1940                1945                1950        
Gln Ala Asp Asp Arg Trp Asp Pro Pro Leu Ala Lys Cys Thr Ser Arg
        1955                1960                1965            
Ala His Asp Ala Leu Ile Val Gly Thr Leu Ser Gly Thr Ile Phe Phe
    1970                1975                1980                
Ile Leu Leu Ile Ile Phe Leu Ser Trp Ile Ile Leu Lys His Arg Lys
1985                1990                1995                2000
Gly Asn Asn Ala His Glu Asn Pro Lys Glu Val Ala Ile His Leu His
                2005                2010                2015    
Ser Gln Gly Gly Ser Ser Val His Pro Arg Thr Leu Gln Thr Asn Glu
            2020                2025                2030        
Glu Asn Ser Arg Val Leu Pro
        2035                


<210> 9118
<211> 504
<212> PRT
<213> Homo sapiens

<400> 9118
Ala Gly Ser Arg Ser Ala Ala Gly Asn Arg Pro Leu Gly Ser Ser Pro
 1               5                  10                  15      
Gly Pro Pro Val Val Pro Arg Pro Arg Gly Val Arg Leu Ala Ala Val
            20                  25                  30          
Trp Val Glu Val Ser Met Ser Gln Gly Val Arg Arg Ala Gly Ala Gly
        35                  40                  45              
Gln Gly Val Ala Ala Ala Val Gln Leu Leu Val Thr Leu Ser Phe Leu
    50                  55                  60                  
Arg Ser Val Val Glu Ala Gln Val Thr Gly Val Leu Asp Asp Cys Leu
65                  70                  75                  80  
Cys Asp Ile Asp Ser Ile Asp Asn Phe Asn Thr Tyr Lys Ile Phe Pro
                85                  90                  95      
Lys Ile Lys Lys Leu Gln Glu Arg Asp Tyr Phe Arg Tyr Tyr Lys Val
            100                 105                 110         
Asn Leu Lys Arg Pro Cys Pro Phe Trp Ala Glu Asp Gly His Cys Ser
        115                 120                 125             
Ile Lys Asp Cys His Val Glu Pro Cys Pro Glu Ser Lys Ile Pro Val
    130                 135                 140                 
Gly Ile Lys Ala Gly His Ser Asn Lys Tyr Leu Lys Met Ala Asn Asn
145                 150                 155                 160 
Thr Lys Glu Leu Glu Val Cys Glu Gln Ala Asn Lys Leu Gly Ala Ile
                165                 170                 175     
Asn Ser Thr Leu Ser Asn Gln Ser Lys Glu Ala Phe Ile Asp Trp Ala
            180                 185                 190         
Arg Tyr Asp Asp Ser Arg Asp His Phe Cys Glu Leu Asp Asp Glu Arg
        195                 200                 205             
Ser Pro Ala Ala Gln Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr
    210                 215                 220                 
Thr Gly Tyr Lys Gly Thr Ser Ala Trp Arg Val Trp Asn Ser Ile Tyr
225                 230                 235                 240 
Glu Glu Asn Cys Phe Lys Pro Arg Ser Val Tyr Arg Pro Leu Asn Pro
                245                 250                 255     
Leu Ala Pro Ser Arg Gly Glu Asp Asp Gly Glu Ser Phe Tyr Thr Trp
            260                 265                 270         
Leu Glu Gly Leu Cys Leu Glu Lys Arg Val Phe Tyr Lys Leu Ile Ser
        275                 280                 285             
Gly Leu His Ala Ser Ile Asn Leu His Leu Cys Ala Asn Tyr Leu Leu
    290                 295                 300                 
Glu Glu Thr Trp Gly Lys Pro Ser Trp Gly Pro Asn Ile Lys Glu Phe
305                 310                 315                 320 
Lys His Arg Phe Asp Pro Val Glu Thr Lys Gly Glu Gly Pro Arg Arg
                325                 330                 335     
Leu Lys Asn Leu Tyr Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser
            340                 345                 350         
Lys Val Ala Pro Tyr Phe Glu Arg Ser Ile Val Asp Leu Tyr Thr Gly
        355                 360                 365             
Asn Ala Glu Glu Asp Ala Asp Thr Lys Thr Leu Leu Leu Asn Ile Phe
    370                 375                 380                 
Gln Asp Thr Lys Ser Phe Pro Met His Phe Asp Glu Lys Ser Met Phe
385                 390                 395                 400 
Ala Gly Asp Lys Lys Gly Ala Lys Ser Leu Lys Glu Glu Phe Arg Leu
                405                 410                 415     
His Phe Lys Asn Ile Ser Arg Ile Met Asp Cys Val Gly Cys Asp Lys
            420                 425                 430         
Cys Arg Leu Trp Gly Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu
        435                 440                 445             
Lys Ile Leu Phe Ser Glu Lys Glu Ile Gln Lys Leu Pro Glu Asn Ser
    450                 455                 460                 
Pro Ser Lys Gly Phe Gln Leu Thr Arg Gln Glu Ile Val Ala Leu Leu
465                 470                 475                 480 
Asn Ala Phe Gly Arg Leu Ser Thr Ser Ile Arg Asp Leu Gln Asn Phe
                485                 490                 495     
Lys Val Leu Leu Gln His Ser Arg
            500                 


<210> 9119
<211> 467
<212> PRT
<213> Homo sapiens

<400> 9119
Met Ser Gln Gly Val Arg Arg Ala Gly Ala Gly Gln Gly Val Ala Ala
 1               5                  10                  15      
Ala Val Gln Leu Leu Val Thr Leu Ser Phe Leu Arg Ser Val Val Glu
            20                  25                  30          
Ala Gln Val Thr Gly Val Leu Asp Asp Cys Leu Cys Asp Ile Asp Ser
        35                  40                  45              
Ile Asp Asn Phe Asn Thr Tyr Lys Ile Phe Pro Lys Ile Lys Lys Leu
    50                  55                  60                  
Gln Glu Arg Asp Tyr Phe Arg Tyr Tyr Lys Val Asn Leu Lys Arg Pro
65                  70                  75                  80  
Cys Pro Phe Trp Ala Glu Asp Gly His Cys Ser Ile Lys Asp Cys His
                85                  90                  95      
Val Glu Pro Cys Pro Glu Ser Lys Ile Pro Val Gly Ile Lys Ala Gly
            100                 105                 110         
His Ser Asn Lys Tyr Leu Lys Met Ala Asn Asn Thr Lys Glu Leu Glu
        115                 120                 125             
Val Cys Glu Gln Ala Asn Lys Leu Gly Ala Ile Asn Ser Thr Leu Ser
    130                 135                 140                 
Asn Gln Ser Lys Glu Ala Phe Ile Asp Trp Ala Arg Tyr Asp Asp Ser
145                 150                 155                 160 
Arg Asp His Phe Cys Glu Leu Asp Asp Glu Arg Ser Pro Ala Ala Gln
                165                 170                 175     
Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys Gly
            180                 185                 190         
Thr Ser Ala Trp Arg Val Trp Asn Ser Ile Tyr Glu Glu Asn Cys Phe
        195                 200                 205             
Lys Pro Arg Ser Val Tyr Arg Pro Leu Asn Pro Leu Ala Pro Ser Arg
    210                 215                 220                 
Gly Glu Asp Asp Gly Glu Ser Phe Tyr Thr Trp Leu Glu Gly Leu Cys
225                 230                 235                 240 
Leu Glu Lys Arg Val Phe Tyr Lys Leu Ile Ser Gly Leu His Ala Ser
                245                 250                 255     
Ile Asn Leu His Leu Cys Ala Asn Tyr Leu Leu Glu Glu Thr Trp Gly
            260                 265                 270         
Lys Pro Ser Trp Gly Pro Asn Ile Lys Glu Phe Lys His Arg Phe Asp
        275                 280                 285             
Pro Val Glu Thr Lys Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu Tyr
    290                 295                 300                 
Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Ala Pro Tyr
305                 310                 315                 320 
Phe Glu Arg Ser Ile Val Asp Leu Tyr Thr Gly Asn Ala Glu Glu Asp
                325                 330                 335     
Ala Asp Thr Lys Thr Leu Leu Leu Asn Ile Phe Gln Asp Thr Lys Ser
            340                 345                 350         
Phe Pro Met His Phe Asp Glu Lys Ser Met Phe Ala Gly Asp Lys Lys
        355                 360                 365             
Gly Ala Lys Ser Leu Lys Glu Glu Phe Arg Leu His Phe Lys Asn Ile
    370                 375                 380                 
Ser Arg Ile Met Asp Cys Val Gly Cys Asp Lys Cys Arg Leu Trp Gly
385                 390                 395                 400 
Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe Ser
                405                 410                 415     
Glu Lys Glu Ile Gln Lys Leu Pro Glu Asn Ser Pro Ser Lys Gly Phe
            420                 425                 430         
Gln Leu Thr Arg Gln Glu Ile Val Ala Leu Leu Asn Ala Phe Gly Arg
        435                 440                 445             
Leu Ser Thr Ser Ile Arg Asp Leu Gln Asn Phe Lys Val Leu Leu Gln
    450                 455                 460                 
His Ser Arg
465         


<210> 9120
<211> 986
<212> PRT
<213> Homo sapiens

<400> 9120
Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro
 1               5                  10                  15      
Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln
            20                  25                  30          
Leu Pro Gly Arg Leu Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala
        35                  40                  45              
Ser Glu Ala Cys Val Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val
    50                  55                  60                  
Pro Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln
65                  70                  75                  80  
Arg Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp
                85                  90                  95      
Gln Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu
            100                 105                 110         
Pro Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro
        115                 120                 125             
Ser Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly
    130                 135                 140                 
Ala Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala
145                 150                 155                 160 
Leu Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala
                165                 170                 175     
Gln Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile
            180                 185                 190         
Leu Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Pro
        195                 200                 205             
Arg Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu
    210                 215                 220                 
Gln Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His
225                 230                 235                 240 
His Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala
                245                 250                 255     
Pro Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro
            260                 265                 270         
Ser Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp
        275                 280                 285             
Pro Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly
    290                 295                 300                 
Ala Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu
305                 310                 315                 320 
Val Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met
                325                 330                 335     
Ala Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro
            340                 345                 350         
Gly Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys
        355                 360                 365             
Ala Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp
    370                 375                 380                 
Asp Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly
385                 390                 395                 400 
Gly Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro
                405                 410                 415     
Phe Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu
            420                 425                 430         
Ser Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys
        435                 440                 445             
Ser Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu
    450                 455                 460                 
Pro Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro
465                 470                 475                 480 
Ser Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser
                485                 490                 495     
Asp Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly
            500                 505                 510         
Tyr Ile Val Thr Asp Arg Glu Val Leu Gly Pro Ala Val Thr Phe Lys
        515                 520                 525             
Val Ser Ala Asn Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala
    530                 535                 540                 
Thr Val Asp Asn Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile
545                 550                 555                 560 
Leu Gln Thr Gly Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro
                565                 570                 575     
Gln Ala Glu Gln Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val
            580                 585                 590         
Ser Leu Ala Cys Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr
        595                 600                 605             
Cys Leu Arg His Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly
    610                 615                 620                 
Leu Gly Gly Asp Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu
625                 630                 635                 640 
Cys Arg Gln Arg Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro
                645                 650                 655     
His Thr Ser Arg Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro
            660                 665                 670         
Ile Pro Ser Pro Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu
        675                 680                 685             
Pro Val Gln Ser Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser
    690                 695                 700                 
Tyr Met Glu Asp His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp
705                 710                 715                 720 
Glu Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala
                725                 730                 735     
Gln Arg Glu Glu Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr
            740                 745                 750         
Tyr Asp His Ser Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His
        755                 760                 765             
Ser Asp Tyr Ile Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn
    770                 775                 780                 
Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp
785                 790                 795                 800 
Phe Trp Gln Met Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu
                805                 810                 815     
Thr Pro Leu Ala Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro
            820                 825                 830         
Asp Glu Gly Ser Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser
        835                 840                 845             
Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys
    850                 855                 860                 
Asn Leu Gln Thr Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu
865                 870                 875                 880 
Ser Trp Tyr Asp Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp
                885                 890                 895     
Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile
            900                 905                 910         
Ile Val His Cys Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu
        915                 920                 925             
Ile Asp Met Val Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp
    930                 935                 940                 
Ile Ala Ala Thr Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val
945                 950                 955                 960 
Gln Thr Lys Glu Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu
                965                 970                 975     
Val Asn Ala Ile Leu Lys Ala Leu Pro Gln
            980                 985     


<210> 9121
<211> 1015
<212> PRT
<213> Homo sapiens

<400> 9121
Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro
 1               5                  10                  15      
Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln
            20                  25                  30          
Leu Pro Gly Arg Leu Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala
        35                  40                  45              
Ser Glu Ala Cys Val Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val
    50                  55                  60                  
Pro Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln
65                  70                  75                  80  
Arg Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp
                85                  90                  95      
Gln Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu
            100                 105                 110         
Pro Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro
        115                 120                 125             
Ser Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly
    130                 135                 140                 
Ala Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala
145                 150                 155                 160 
Leu Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala
                165                 170                 175     
Gln Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile
            180                 185                 190         
Leu Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Pro
        195                 200                 205             
Arg Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu
    210                 215                 220                 
Gln Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His
225                 230                 235                 240 
His Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala
                245                 250                 255     
Pro Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro
            260                 265                 270         
Ser Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp
        275                 280                 285             
Pro Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly
    290                 295                 300                 
Ala Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu
305                 310                 315                 320 
Val Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met
                325                 330                 335     
Ala Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro
            340                 345                 350         
Gly Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys
        355                 360                 365             
Ala Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp
    370                 375                 380                 
Asp Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly
385                 390                 395                 400 
Gly Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro
                405                 410                 415     
Phe Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu
            420                 425                 430         
Ser Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys
        435                 440                 445             
Ser Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu
    450                 455                 460                 
Pro Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro
465                 470                 475                 480 
Ser Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser
                485                 490                 495     
Asp Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly
            500                 505                 510         
Tyr Ile Val Thr Asp Arg Asp Pro Leu Arg Pro Glu Glu Gly Arg Arg
        515                 520                 525             
Leu Val Glu Asp Val Ala Arg Leu Leu Gln Val Pro Ser Ser Ala Phe
    530                 535                 540                 
Ala Asp Val Glu Val Leu Gly Pro Ala Val Thr Phe Lys Val Ser Ala
545                 550                 555                 560 
Asn Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala Thr Val Asp
                565                 570                 575     
Asn Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile Leu Gln Thr
            580                 585                 590         
Gly Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro Gln Ala Glu
        595                 600                 605             
Gln Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val Ser Leu Ala
    610                 615                 620                 
Cys Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr Cys Leu Arg
625                 630                 635                 640 
His Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly Leu Gly Gly
                645                 650                 655     
Asp Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu Cys Arg Gln
            660                 665                 670         
Arg Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro His Thr Ser
        675                 680                 685             
Arg Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro Ile Pro Ser
    690                 695                 700                 
Pro Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu Pro Val Gln
705                 710                 715                 720 
Ser Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser Tyr Met Glu
                725                 730                 735     
Asp His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp Glu Ala Leu
            740                 745                 750         
Cys Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala Gln Arg Glu
        755                 760                 765             
Glu Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His
    770                 775                 780                 
Ser Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr
785                 790                 795                 800 
Ile Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn Pro Ala Tyr
                805                 810                 815     
Ile Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp Phe Trp Gln
            820                 825                 830         
Met Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu Thr Pro Leu
        835                 840                 845             
Ala Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro Asp Glu Gly
    850                 855                 860                 
Ser Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser Glu His Ile
865                 870                 875                 880 
Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu Gln
                885                 890                 895     
Thr Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu Ser Trp Tyr
            900                 905                 910         
Asp Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp Phe Arg Arg
        915                 920                 925             
Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His
    930                 935                 940                 
Cys Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu Ile Asp Met
945                 950                 955                 960 
Val Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp Ile Ala Ala
                965                 970                 975     
Thr Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val Gln Thr Lys
            980                 985                 990         
Glu Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala
        995                 1000                1005            
Ile Leu Lys Ala Leu Pro Gln
    1010                1015


<210> 9122
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 9122
Asn Asp Ser Gln Met Ala Val Glu Ser Glu Tyr Ser Leu Leu Arg Thr
 1               5                  10                  15      
Glu Ala Ser Phe Pro Thr Met Lys Met Phe Cys Val Ser His Thr Leu
            20                  25                  30          
Pro Arg Val Glu Val Met Phe Val Ser Gly Pro Gln Thr Arg Glu Arg
        35                  40                  45              
Thr Glu Pro Val Asp Pro Arg Trp Gln Cys Leu Val Gln Met Trp Ala
    50                  55                  60                  
Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala Ser Glu Ala Cys Val
65                  70                  75                  80  
Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val Pro Ala Met Asp Phe
                85                  90                  95      
Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln Arg Leu Arg Val Ala
            100                 105                 110         
Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp Gln Asp Asp Tyr Thr
        115                 120                 125             
Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu Pro Lys Thr Tyr Leu
    130                 135                 140                 
Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro Ser Lys His Ser Val
145                 150                 155                 160 
Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly Ala Ala Leu Ala Asn
                165                 170                 175     
Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala Leu Ser Gln Ala Pro
            180                 185                 190         
Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala Gln Asp Arg Pro Pro
        195                 200                 205             
Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile Leu Thr Tyr Val Ala
    210                 215                 220                 
His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Pro Arg Thr Gln Leu His
225                 230                 235                 240 
Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu Gln Pro Asp Glu Leu
                245                 250                 255     
Ser Pro Lys Val Asp Ser Gly Val Asp Arg His His Leu Met Ala Ala
            260                 265                 270         
Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala Pro Pro Gly Glu Gly
        275                 280                 285             
Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro Ser Arg Met Pro Arg
    290                 295                 300                 
Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp Pro Ser Pro Leu Gly
305                 310                 315                 320 
Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly Ala Arg Ile His Thr
                325                 330                 335     
Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu Val Arg Gly Leu Ser
            340                 345                 350         
Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met Ala Gly Leu Met Gln
        355                 360                 365             
Gly Val Asp His Gly Val Ala Arg Gly Ser Pro Gly Arg Ala Ala Leu
    370                 375                 380                 
Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys Ala Thr Leu Arg Gly
385                 390                 395                 400 
Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp Asp Asp Arg Leu Tyr
                405                 410                 415     
Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly Gly Leu Leu Gln Asp
            420                 425                 430         
His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro Phe Ala Arg Pro Leu
        435                 440                 445             
Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu Ser Ser Leu Ser Ser
    450                 455                 460                 
Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys Ser Gln Thr Tyr Ser
465                 470                 475                 480 
Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu Pro Gly Ala Ala Ala
                485                 490                 495     
Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro Ser Lys Glu Glu Gln
            500                 505                 510         
Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser Asp Gly Leu Gln Leu
        515                 520                 525             
Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly Tyr Ile Val Thr Asp
    530                 535                 540                 
Arg Asp Pro Leu Arg Pro Glu Glu Gly Arg Arg Leu Val Glu Asp Val
545                 550                 555                 560 
Ala Arg Leu Leu Gln Val Pro Ser Ser Ala Phe Ala Asp Val Glu Val
                565                 570                 575     
Leu Gly Pro Ala Val Thr Phe Lys Val Ser Ala Asn Val Gln Asn Val
            580                 585                 590         
Thr Thr Glu Asp Val Glu Lys Ala Thr Val Asp Asn Lys Asp Lys Leu
        595                 600                 605             
Glu Glu Thr Ser Gly Leu Lys Ile Leu Gln Thr Gly Val Gly Ser Lys
    610                 615                 620                 
Ser Lys Leu Lys Phe Leu Pro Pro Gln Ala Glu Gln Glu Asp Ser Thr
625                 630                 635                 640 
Lys Phe Ile Ala Leu Thr Leu Val Ser Leu Ala Cys Ile Leu Gly Val
                645                 650                 655     
Leu Leu Ala Ser Gly Leu Ile Tyr Cys Leu Arg His Ser Ser Gln His
            660                 665                 670         
Arg Leu Lys Glu Lys Leu Ser Gly Leu Gly Gly Asp Pro Gly Ala Asp
        675                 680                 685             
Ala Thr Ala Ala Tyr Gln Glu Leu Cys Arg Gln Arg Met Ala Thr Arg
    690                 695                 700                 
Pro Pro Asp Arg Pro Glu Gly Pro His Thr Ser Arg Ile Ser Ser Val
705                 710                 715                 720 
Ser Ser Gln Phe Ser Asp Gly Pro Ile Pro Ser Pro Ser Ala Arg Ser
                725                 730                 735     
Ser Ala Ser Ser Trp Ser Glu Glu Pro Val Gln Ser Asn Met Asp Ile
            740                 745                 750         
Ser Thr Gly His Met Ile Leu Ser Tyr Met Glu Asp His Leu Lys Asn
        755                 760                 765             
Lys Asn Arg Leu Glu Lys Glu Trp Glu Ala Leu Cys Ala Tyr Gln Ala
    770                 775                 780                 
Glu Pro Asn Ser Ser Phe Val Ala Gln Arg Glu Glu Asn Val Pro Lys
785                 790                 795                 800 
Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His Ser Arg Val Leu Leu
                805                 810                 815     
Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr Ile Asn Ala Ser Pro
            820                 825                 830         
Ile Met Asp His Asp Pro Arg Asn Pro Ala Tyr Ile Ala Thr Gln Gly
        835                 840                 845             
Pro Leu Pro Ala Thr Val Ala Asp Phe Trp Gln Met Val Trp Glu Ser
    850                 855                 860                 
Gly Cys Val Val Ile Val Met Leu Thr Pro Leu Ala Glu Asn Gly Val
865                 870                 875                 880 
Arg Gln Cys Tyr His Tyr Trp Pro Asp Glu Gly Ser Asn Leu Tyr His
                885                 890                 895     
Ile Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp Phe
            900                 905                 910         
Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu Gln Thr Asn Glu Thr Arg
        915                 920                 925             
Thr Val Thr Gln Phe His Phe Leu Ser Trp Tyr Asp Arg Gly Val Pro
    930                 935                 940                 
Ser Ser Ser Arg Ser Leu Leu Asp Phe Arg Arg Lys Val Asn Lys Cys
945                 950                 955                 960 
Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly Ala
                965                 970                 975     
Gly Arg Ser Gly Thr Tyr Val Leu Ile Asp Met Val Leu Asn Lys Met
            980                 985                 990         
Ala Lys Gly Ala Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Leu
        995                 1000                1005            
Arg Asp Gln Arg Pro Gly Met Val Gln Thr Lys Glu Gln Phe Glu Phe
    1010                1015                1020                
Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala Leu
1025                1030                1035                1040
Pro Gln
        


<210> 9123
<211> 450
<212> PRT
<213> Homo sapiens

<400> 9123
Met Ser Val Glu Cys Lys Leu Ala Leu Leu Lys Tyr Leu Cys Glu Cys
 1               5                  10                  15      
Gln Phe Gly Asp Asn Leu Lys Phe Lys Asn Ile Ile Asn Glu Glu Asp
            20                  25                  30          
Ala Asp Thr Met Arg Leu Gln Pro Ile Gly Arg Asp Lys Asp Gly Leu
        35                  40                  45              
Met Tyr Trp Tyr Gln Leu Asp Gln Asp His Asn Val Arg Met Tyr Ile
    50                  55                  60                  
Glu Glu Gln Asp Asp Gln Asp Gly Ser Ser Trp Lys Cys Ile Val Arg
65                  70                  75                  80  
Asn Arg Asn Glu Leu Ala Glu Thr Leu Ala Leu Leu Lys Ala Gln Ile
                85                  90                  95      
Asp Pro Val Leu Leu Lys Asn Ser Ser Gln Gln Asp Asn Ser Ser Arg
            100                 105                 110         
Glu Ser Pro Ser Leu Glu Asp Glu Glu Thr Lys Lys Glu Glu Glu Thr
        115                 120                 125             
Pro Lys Gln Glu Glu Gln Lys Glu Ser Glu Lys Met Lys Ser Glu Glu
    130                 135                 140                 
Gln Pro Met Asp Leu Glu Asn Arg Ser Thr Ala Asn Gly Leu Glu Glu
145                 150                 155                 160 
Thr Thr Gly Lys Lys Glu Lys Glu Asp Glu Lys Glu Leu Ala Lys Leu
                165                 170                 175     
Pro Gly Ile Val Lys Leu Glu Lys Pro Leu Pro Glu Asn Glu Glu Asn
            180                 185                 190         
Lys Ile Ile Lys Glu Glu Ser Asp Pro Ser Lys Glu Asn Val Lys Pro
        195                 200                 205             
Ile Lys Val Glu Val Lys Glu Cys Arg Ala Asp Pro Lys Asp Thr Lys
    210                 215                 220                 
Ser Ser Met Glu Lys Pro Val Ala Gln Glu Pro Glu Gly Ser Glu Leu
225                 230                 235                 240 
Gly Gly Asn Ile Lys Ser Ser His Glu Ile Thr Glu Lys Ser Thr Glu
                245                 250                 255     
Glu Thr Glu Lys Leu Lys Asn Asp Gln Gln Ala Glu Ile Pro Leu Lys
            260                 265                 270         
Lys Arg Glu Ile Lys Leu Ser Asp Asp Phe Asp Ser Pro Val Lys Gly
        275                 280                 285             
Pro Leu Cys Lys Ser Val Thr Pro Thr Lys Glu Phe Leu Lys Asp Glu
    290                 295                 300                 
Ile Lys Gln Glu Glu Glu Thr Cys Lys Arg Ile Ser Thr Ile Thr Ala
305                 310                 315                 320 
Leu Gly His Glu Gly Lys Gln Leu Val Asn Gly Glu Val Ser Asp Glu
                325                 330                 335     
Arg Val Ala Pro Asn Phe Lys Thr Glu Pro Ile Glu Thr Lys Phe Tyr
            340                 345                 350         
Glu Thr Lys Glu Glu Ser Tyr Ser Pro Ser Lys Asp Arg Asn Ile Ile
        355                 360                 365             
Thr Glu Gly Asn Gly Thr Glu Ser Leu Asn Ser Val Ile Thr Ser Met
    370                 375                 380                 
Lys Thr Gly Glu Leu Glu Lys Glu Thr Ala Pro Leu Arg Lys Asp Ala
385                 390                 395                 400 
Asp Ser Ser Ile Ser Val Leu Glu Ile His Ser Gln Lys Ala Gln Ile
                405                 410                 415     
Glu Glu Pro Asp Pro Pro Glu Met Glu Thr Ser Leu Asp Ser Ser Glu
            420                 425                 430         
Met Ala Lys Ile Ser Leu Gln Lys Leu Leu Tyr Leu Pro Pro Ser Arg
        435                 440                 445             
Val Pro
    450 


<210> 9124
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 9124
Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp
 1               5                  10                  15      
Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg
            20                  25                  30          
Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu
        35                  40                  45              
Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser
    50                  55                  60                  
Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val
65                  70                  75                  80  
Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr
                85                  90                  95      
Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr
            100                 105                 110         
Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr
        115                 120                 125             
Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser
    130                 135                 140                 
Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val
145                 150                 155                 160 
Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr
                165                 170                 175     
Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala
            180                 185                 190         
Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu
        195                 200                 205             
Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu
    210                 215                 220                 
Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe
225                 230                 235                 240 
Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn
                245                 250                 255     
Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg
            260                 265                 270         
Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys
        275                 280                 285             
Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu
    290                 295                 300                 
Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro
305                 310                 315                 320 
Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser
                325                 330                 335     
Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe
            340                 345                 350         
Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu
        355                 360                 365             
Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala
    370                 375                 380                 
Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala
385                 390                 395                 400 
Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile
                405                 410                 415     
Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr
            420                 425                 430         
Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp
        435                 440                 445             
Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu
    450                 455                 460                 
Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile
465                 470                 475                 480 
Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys
                485                 490                 495     
Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys
            500                 505                 510         
Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu
        515                 520                 525             
Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro
    530                 535                 540                 
Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp
545                 550                 555                 560 
Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro
                565                 570                 575     
Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln
            580                 585                 590         
Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu
        595                 600                 605             
Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr
    610                 615                 620                 
Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu
625                 630                 635                 640 
His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu
                645                 650                 655     
Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu
            660                 665                 670         
Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His
        675                 680                 685             
Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser
    690                 695                 700                 
Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln
705                 710                 715                 720 
Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp
                725                 730                 735     
Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro
            740                 745                 750         
Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu
        755                 760                 765             
Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val
    770                 775                 780                 
Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His
785                 790                 795                 800 
Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val
                805                 810                 815     
Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser
            820                 825                 830         
Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln
        835                 840                 845             
Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro
    850                 855                 860                 
Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp
865                 870                 875                 880 
Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu
                885                 890                 895     
Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu
            900                 905                 910         
Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly
        915                 920                 925             
Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser
    930                 935                 940                 
Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr
945                 950                 955                 960 
Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys
                965                 970                 975     
Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser
            980                 985                 990         
Thr Glu Ser Leu Asp Cys Glu Val Asn Asn Asn Gly Ser Asn Arg Ala
        995                 1000                1005            
Val His Ser Lys Ser Ser Thr Ala Val Tyr Leu Ala Glu Gly Gly Thr
    1010                1015                1020                
Ala Thr Thr Met Val Ser Lys Asp Ile Gly Met Asn Cys Leu
1025                1030                1035            


<210> 9125
<211> 1822
<212> PRT
<213> Homo sapiens

<400> 9125
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala
 1               5                  10                  15      
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys
            20                  25                  30          
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys
        35                  40                  45              
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln
    50                  55                  60                  
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met
65                  70                  75                  80  
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu
                85                  90                  95      
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro
            100                 105                 110         
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser
        115                 120                 125             
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp
    130                 135                 140                 
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu
145                 150                 155                 160 
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp
                165                 170                 175     
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu
            180                 185                 190         
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser
        195                 200                 205             
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg
    210                 215                 220                 
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu
225                 230                 235                 240 
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr
                245                 250                 255     
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp
            260                 265                 270         
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys
        275                 280                 285             
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr
    290                 295                 300                 
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile
305                 310                 315                 320 
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu
                325                 330                 335     
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser
            340                 345                 350         
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser
        355                 360                 365             
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu
    370                 375                 380                 
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile
385                 390                 395                 400 
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu
                405                 410                 415     
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly
            420                 425                 430         
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala
        435                 440                 445             
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg
    450                 455                 460                 
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val
465                 470                 475                 480 
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser
                485                 490                 495     
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys
            500                 505                 510         
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu
        515                 520                 525             
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro
    530                 535                 540                 
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly
545                 550                 555                 560 
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro
                565                 570                 575     
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly
            580                 585                 590         
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu
        595                 600                 605             
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly
    610                 615                 620                 
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr
625                 630                 635                 640 
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys
                645                 650                 655     
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser
            660                 665                 670         
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly
        675                 680                 685             
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys
    690                 695                 700                 
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu
705                 710                 715                 720 
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys
                725                 730                 735     
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly
            740                 745                 750         
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu
        755                 760                 765             
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu
    770                 775                 780                 
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg
785                 790                 795                 800 
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val
                805                 810                 815     
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu
            820                 825                 830         
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu
        835                 840                 845             
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu
    850                 855                 860                 
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp
865                 870                 875                 880 
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro
                885                 890                 895     
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His
            900                 905                 910         
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp
        915                 920                 925             
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val
    930                 935                 940                 
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu
945                 950                 955                 960 
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg
                965                 970                 975     
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val
            980                 985                 990         
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala
        995                 1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Gly Cys Gly Trp Lys Phe Glu
                1365                1370                1375    
Pro Leu Leu Gly Glu Glu Leu Asp Leu Arg Arg Val Thr Trp Arg Leu
            1380                1385                1390        
Pro Pro Glu Leu Ile Pro Arg Leu Ser Ala Ser Ser Gly Arg Ser Ser
        1395                1400                1405            
Asp Ala Glu Ala Pro His Gly Pro Pro Asp Asp Gly Gly Ala Gly Gly
    1410                1415                1420                
Lys Gly Gly Ser Leu Pro Arg Ser Ala Thr Pro Gly Pro Pro Gly Glu
1425                1430                1435                1440
His Leu Val Asn Gly Arg Met Asp Phe Ala Phe Pro Gly Ser Thr Asn
                1445                1450                1455    
Ser Leu His Arg Met Thr Thr Thr Ser Ala Ala Ala Tyr Gly Thr His
            1460                1465                1470        
Leu Ser Pro His Val Pro His Arg Val Leu Ser Thr Ser Ser Thr Leu
        1475                1480                1485            
Thr Arg Asp Tyr Asn Ser Leu Thr Arg Ser Glu His Ser His Ser Thr
    1490                1495                1500                
Thr Leu Pro Arg Asp Tyr Ser Thr Leu Thr Ser Val Ser Ser His Asp
1505                1510                1515                1520
Ser Arg Leu Thr Ala Gly Val Pro Asp Thr Pro Thr Arg Leu Val Phe
                1525                1530                1535    
Ser Ala Leu Gly Pro Thr Ser Leu Arg Val Ser Trp Gln Glu Pro Arg
            1540                1545                1550        
Cys Glu Arg Pro Leu Gln Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn
        1555                1560                1565            
Gly Gly Glu Leu His Arg Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser
    1570                1575                1580                
Val Val Val Glu Asp Leu Leu Pro Asn His Ser Tyr Val Phe Arg Val
1585                1590                1595                1600
Arg Ala Gln Ser Gln Glu Gly Trp Gly Arg Glu Arg Glu Gly Val Ile
                1605                1610                1615    
Thr Ile Glu Ser Gln Val His Pro Gln Ser Pro Leu Cys Pro Leu Pro
            1620                1625                1630        
Gly Ser Ala Phe Thr Leu Ser Thr Pro Ser Ala Pro Gly Pro Leu Val
        1635                1640                1645            
Phe Thr Ala Leu Ser Pro Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro
    1650                1655                1660                
Arg Arg Pro Asn Gly Asp Ile Val Gly Tyr Leu Val Thr Cys Glu Met
1665                1670                1675                1680
Ala Gln Gly Gly Gly Pro Ala Thr Ala Phe Arg Val Asp Gly Asp Ser
                1685                1690                1695    
Pro Glu Ser Arg Leu Thr Val Pro Gly Leu Ser Glu Asn Val Pro Tyr
            1700                1705                1710        
Lys Phe Lys Val Gln Ala Arg Thr Thr Glu Gly Phe Gly Pro Glu Arg
        1715                1720                1725            
Glu Gly Ile Ile Thr Ile Glu Ser Gln Asp Gly Gly Pro Phe Pro Gln
    1730                1735                1740                
Leu Gly Ser Arg Ala Gly Leu Phe Gln His Pro Leu Gln Ser Glu Tyr
1745                1750                1755                1760
Ser Ser Ile Thr Thr Thr His Thr Ser Ala Thr Glu Pro Phe Leu Val
                1765                1770                1775    
Asp Gly Pro Thr Leu Gly Ala Gln His Leu Glu Ala Gly Gly Ser Leu
            1780                1785                1790        
Thr Arg His Val Thr Gln Glu Phe Val Ser Arg Thr Leu Thr Thr Ser
        1795                1800                1805            
Gly Thr Leu Ser Thr His Met Asp Gln Gln Phe Phe Gln Thr
    1810                1815                1820        


<210> 9126
<211> 1805
<212> PRT
<213> Homo sapiens

<400> 9126
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala
 1               5                  10                  15      
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys
            20                  25                  30          
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys
        35                  40                  45              
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln
    50                  55                  60                  
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met
65                  70                  75                  80  
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu
                85                  90                  95      
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro
            100                 105                 110         
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser
        115                 120                 125             
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp
    130                 135                 140                 
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu
145                 150                 155                 160 
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp
                165                 170                 175     
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu
            180                 185                 190         
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser
        195                 200                 205             
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg
    210                 215                 220                 
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu
225                 230                 235                 240 
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr
                245                 250                 255     
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp
            260                 265                 270         
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys
        275                 280                 285             
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr
    290                 295                 300                 
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile
305                 310                 315                 320 
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu
                325                 330                 335     
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser
            340                 345                 350         
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser
        355                 360                 365             
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu
    370                 375                 380                 
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile
385                 390                 395                 400 
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu
                405                 410                 415     
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly
            420                 425                 430         
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala
        435                 440                 445             
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg
    450                 455                 460                 
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val
465                 470                 475                 480 
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser
                485                 490                 495     
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys
            500                 505                 510         
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu
        515                 520                 525             
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro
    530                 535                 540                 
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly
545                 550                 555                 560 
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro
                565                 570                 575     
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly
            580                 585                 590         
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu
        595                 600                 605             
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly
    610                 615                 620                 
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr
625                 630                 635                 640 
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys
                645                 650                 655     
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser
            660                 665                 670         
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly
        675                 680                 685             
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys
    690                 695                 700                 
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu
705                 710                 715                 720 
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys
                725                 730                 735     
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly
            740                 745                 750         
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu
        755                 760                 765             
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu
    770                 775                 780                 
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg
785                 790                 795                 800 
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val
                805                 810                 815     
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu
            820                 825                 830         
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu
        835                 840                 845             
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu
    850                 855                 860                 
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp
865                 870                 875                 880 
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro
                885                 890                 895     
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His
            900                 905                 910         
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp
        915                 920                 925             
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val
    930                 935                 940                 
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu
945                 950                 955                 960 
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg
                965                 970                 975     
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val
            980                 985                 990         
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala
        995                 1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Glu His Leu Val Asn Gly Arg
                1365                1370                1375    
Met Asp Phe Ala Phe Pro Gly Ser Thr Asn Ser Leu His Arg Met Thr
            1380                1385                1390        
Thr Thr Ser Ala Ala Ala Tyr Gly Thr His Leu Ser Pro His Val Pro
        1395                1400                1405            
His Arg Val Leu Ser Thr Ser Ser Thr Leu Thr Arg Asp Tyr Asn Ser
    1410                1415                1420                
Leu Thr Arg Ser Glu His Ser His Ser Thr Thr Leu Pro Arg Asp Tyr
1425                1430                1435                1440
Ser Thr Leu Thr Ser Val Ser Ser His Gly Leu Pro Pro Ile Trp Glu
                1445                1450                1455    
His Gly Arg Ser Arg Leu Pro Leu Ser Trp Ala Leu Gly Ser Arg Ser
            1460                1465                1470        
Arg Ala Gln Met Lys Gly Phe Pro Pro Ser Arg Gly Pro Arg Asp Ser
        1475                1480                1485            
Ile Ile Leu Ala Gly Arg Pro Ala Ala Pro Ser Trp Gly Pro Asp Ser
    1490                1495                1500                
Arg Leu Thr Ala Gly Val Pro Asp Thr Pro Thr Arg Leu Val Phe Ser
1505                1510                1515                1520
Ala Leu Gly Pro Thr Ser Leu Arg Val Ser Trp Gln Glu Pro Arg Cys
                1525                1530                1535    
Glu Arg Pro Leu Gln Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn Gly
            1540                1545                1550        
Gly Glu Leu His Arg Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser Val
        1555                1560                1565            
Val Val Glu Asp Leu Leu Pro Asn His Ser Tyr Val Phe Arg Val Arg
    1570                1575                1580                
Ala Gln Ser Gln Glu Gly Trp Gly Arg Glu Arg Glu Gly Val Ile Thr
1585                1590                1595                1600
Ile Glu Ser Gln Val His Pro Gln Ser Pro Leu Cys Pro Leu Pro Gly
                1605                1610                1615    
Ser Ala Phe Thr Leu Ser Thr Pro Ser Ala Pro Gly Pro Leu Val Phe
            1620                1625                1630        
Thr Ala Leu Ser Pro Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro Arg
        1635                1640                1645            
Arg Pro Asn Gly Asp Ile Val Gly Tyr Leu Val Thr Cys Glu Met Ala
    1650                1655                1660                
Gln Gly Gly Gly Pro Ala Thr Ala Phe Arg Val Asp Gly Asp Ser Pro
1665                1670                1675                1680
Glu Ser Arg Leu Thr Val Pro Gly Leu Ser Glu Asn Val Pro Tyr Lys
                1685                1690                1695    
Phe Lys Val Gln Ala Arg Thr Thr Glu Gly Phe Gly Pro Glu Arg Glu
            1700                1705                1710        
Gly Ile Ile Thr Ile Glu Ser Gln Asp Gly Gly Pro Phe Pro Gln Leu
        1715                1720                1725            
Gly Ser Arg Ala Gly Leu Phe Gln His Pro Leu Gln Ser Glu Tyr Ser
    1730                1735                1740                
Ser Ile Thr Thr Thr His Thr Ser Ala Thr Glu Pro Phe Leu Val Asp
1745                1750                1755                1760
Gly Pro Thr Leu Gly Ala Gln His Leu Glu Ala Gly Gly Ser Leu Thr
                1765                1770                1775    
Arg His Val Thr Gln Glu Phe Val Ser Arg Thr Leu Thr Thr Ser Gly
            1780                1785                1790        
Thr Leu Ser Thr His Met Asp Gln Gln Phe Phe Gln Thr
        1795                1800                1805


<210> 9127
<211> 1752
<212> PRT
<213> Homo sapiens

<400> 9127
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala
 1               5                  10                  15      
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys
            20                  25                  30          
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys
        35                  40                  45              
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln
    50                  55                  60                  
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met
65                  70                  75                  80  
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu
                85                  90                  95      
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro
            100                 105                 110         
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser
        115                 120                 125             
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp
    130                 135                 140                 
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu
145                 150                 155                 160 
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp
                165                 170                 175     
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu
            180                 185                 190         
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser
        195                 200                 205             
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg
    210                 215                 220                 
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu
225                 230                 235                 240 
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr
                245                 250                 255     
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp
            260                 265                 270         
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys
        275                 280                 285             
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr
    290                 295                 300                 
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile
305                 310                 315                 320 
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu
                325                 330                 335     
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser
            340                 345                 350         
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser
        355                 360                 365             
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu
    370                 375                 380                 
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile
385                 390                 395                 400 
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu
                405                 410                 415     
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly
            420                 425                 430         
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala
        435                 440                 445             
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg
    450                 455                 460                 
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val
465                 470                 475                 480 
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser
                485                 490                 495     
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys
            500                 505                 510         
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu
        515                 520                 525             
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro
    530                 535                 540                 
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly
545                 550                 555                 560 
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro
                565                 570                 575     
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly
            580                 585                 590         
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu
        595                 600                 605             
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly
    610                 615                 620                 
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr
625                 630                 635                 640 
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys
                645                 650                 655     
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser
            660                 665                 670         
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly
        675                 680                 685             
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys
    690                 695                 700                 
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu
705                 710                 715                 720 
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys
                725                 730                 735     
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly
            740                 745                 750         
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu
        755                 760                 765             
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu
    770                 775                 780                 
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg
785                 790                 795                 800 
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val
                805                 810                 815     
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu
            820                 825                 830         
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu
        835                 840                 845             
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu
    850                 855                 860                 
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp
865                 870                 875                 880 
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro
                885                 890                 895     
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His
            900                 905                 910         
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp
        915                 920                 925             
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val
    930                 935                 940                 
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu
945                 950                 955                 960 
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg
                965                 970                 975     
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val
            980                 985                 990         
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala
        995                 1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Glu His Leu Val Asn Gly Arg
                1365                1370                1375    
Met Asp Phe Ala Phe Pro Gly Ser Thr Asn Ser Leu His Arg Met Thr
            1380                1385                1390        
Thr Thr Ser Ala Ala Ala Tyr Gly Thr His Leu Ser Pro His Val Pro
        1395                1400                1405            
His Arg Val Leu Ser Thr Ser Ser Thr Leu Thr Arg Asp Tyr Asn Ser
    1410                1415                1420                
Leu Thr Arg Ser Glu His Ser His Ser Thr Thr Leu Pro Arg Asp Tyr
1425                1430                1435                1440
Ser Thr Leu Thr Ser Val Ser Ser His Asp Ser Arg Leu Thr Ala Gly
                1445                1450                1455    
Val Pro Asp Thr Pro Thr Arg Leu Val Phe Ser Ala Leu Gly Pro Thr
            1460                1465                1470        
Ser Leu Arg Val Ser Trp Gln Glu Pro Arg Cys Glu Arg Pro Leu Gln
        1475                1480                1485            
Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn Gly Gly Glu Leu His Arg
    1490                1495                1500                
Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser Val Val Val Glu Asp Leu
1505                1510                1515                1520
Leu Pro Asn His Ser Tyr Val Phe Arg Val Arg Ala Gln Ser Gln Glu
                1525                1530                1535    
Gly Trp Gly Arg Glu Arg Glu Gly Val Ile Thr Ile Glu Ser Gln Val
            1540                1545                1550        
His Pro Gln Ser Pro Leu Cys Pro Leu Pro Gly Ser Ala Phe Thr Leu
        1555                1560                1565            
Ser Thr Pro Ser Ala Pro Gly Pro Leu Val Phe Thr Ala Leu Ser Pro
    1570                1575                1580                
Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro Arg Arg Pro Asn Gly Asp
1585                1590                1595                1600
Ile Val Gly Tyr Leu Val Thr Cys Glu Met Ala Gln Gly Gly Gly Pro
                1605                1610                1615    
Ala Thr Ala Phe Arg Val Asp Gly Asp Ser Pro Glu Ser Arg Leu Thr
            1620                1625                1630        
Val Pro Gly Leu Ser Glu Asn Val Pro Tyr Lys Phe Lys Val Gln Ala
        1635                1640                1645            
Arg Thr Thr Glu Gly Phe Gly Pro Glu Arg Glu Gly Ile Ile Thr Ile
    1650                1655                1660                
Glu Ser Gln Asp Gly Gly Pro Phe Pro Gln Leu Gly Ser Arg Ala Gly
1665                1670                1675                1680
Leu Phe Gln His Pro Leu Gln Ser Glu Tyr Ser Ser Ile Thr Thr Thr
                1685                1690                1695    
His Thr Ser Ala Thr Glu Pro Phe Leu Val Asp Gly Pro Thr Leu Gly
            1700                1705                1710        
Ala Gln His Leu Glu Ala Gly Gly Ser Leu Thr Arg His Val Thr Gln
        1715                1720                1725            
Glu Phe Val Ser Arg Thr Leu Thr Thr Ser Gly Thr Leu Ser Thr His
    1730                1735                1740                
Met Asp Gln Gln Phe Phe Gln Thr
1745                1750        


<210> 9128
<211> 964
<212> PRT
<213> Homo sapiens

<400> 9128
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala
 1               5                  10                  15      
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys
            20                  25                  30          
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys
        35                  40                  45              
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln
    50                  55                  60                  
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met
65                  70                  75                  80  
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu
                85                  90                  95      
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro
            100                 105                 110         
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser
        115                 120                 125             
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp
    130                 135                 140                 
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu
145                 150                 155                 160 
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp
                165                 170                 175     
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu
            180                 185                 190         
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser
        195                 200                 205             
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg
    210                 215                 220                 
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu
225                 230                 235                 240 
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr
                245                 250                 255     
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp
            260                 265                 270         
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys
        275                 280                 285             
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr
    290                 295                 300                 
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile
305                 310                 315                 320 
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu
                325                 330                 335     
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser
            340                 345                 350         
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser
        355                 360                 365             
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu
    370                 375                 380                 
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile
385                 390                 395                 400 
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu
                405                 410                 415     
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly
            420                 425                 430         
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala
        435                 440                 445             
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg
    450                 455                 460                 
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val
465                 470                 475                 480 
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser
                485                 490                 495     
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys
            500                 505                 510         
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu
        515                 520                 525             
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro
    530                 535                 540                 
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly
545                 550                 555                 560 
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro
                565                 570                 575     
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly
            580                 585                 590         
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu
        595                 600                 605             
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly
    610                 615                 620                 
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr
625                 630                 635                 640 
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys
                645                 650                 655     
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser
            660                 665                 670         
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly
        675                 680                 685             
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys
    690                 695                 700                 
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu
705                 710                 715                 720 
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys
                725                 730                 735     
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly
            740                 745                 750         
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu
        755                 760                 765             
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu
    770                 775                 780                 
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg
785                 790                 795                 800 
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val
                805                 810                 815     
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu
            820                 825                 830         
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu
        835                 840                 845             
Glu Asn Val Arg Thr Gln Glu Leu Gly Leu Ala Gly Asp Val Ala Glu
    850                 855                 860                 
Arg Gly Leu Gln Ala Asp Leu Arg Cys Thr Gln Ala Pro Ala Asp Gln
865                 870                 875                 880 
Val Pro Ala Ala Ala Gln Cys Arg Glu Lys Ala Arg Pro His His Cys
                885                 890                 895     
Gly His Ser Ala Asp Gly Ala Pro Leu Gly Gln Ala Gly Pro Ala Glu
            900                 905                 910         
Ala Tyr Arg Glu Ala Gly Gly Thr Glu Gly Leu Pro Arg Pro Gln Gly
        915                 920                 925             
Gly Pro Arg Leu Leu His Pro His Cys Arg Pro Gly Arg Pro Gly His
    930                 935                 940                 
Gly Gly Val Pro Gly Gly Arg Gly Ala Gly Gly Arg Thr Gly Ala Pro
945                 950                 955                 960 
Leu Tyr Pro Ala
                


<210> 9129
<211> 1745
<212> PRT
<213> Homo sapiens

<400> 9129
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala
 1               5                  10                  15      
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys
            20                  25                  30          
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys
        35                  40                  45              
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln
    50                  55                  60                  
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met
65                  70                  75                  80  
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu
                85                  90                  95      
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro
            100                 105                 110         
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser
        115                 120                 125             
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp
    130                 135                 140                 
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu
145                 150                 155                 160 
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp
                165                 170                 175     
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu
            180                 185                 190         
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser
        195                 200                 205             
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg
    210                 215                 220                 
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu
225                 230                 235                 240 
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr
                245                 250                 255     
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp
            260                 265                 270         
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys
        275                 280                 285             
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr
    290                 295                 300                 
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile
305                 310                 315                 320 
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu
                325                 330                 335     
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser
            340                 345                 350         
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser
        355                 360                 365             
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu
    370                 375                 380                 
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile
385                 390                 395                 400 
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu
                405                 410                 415     
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly
            420                 425                 430         
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala
        435                 440                 445             
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg
    450                 455                 460                 
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val
465                 470                 475                 480 
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser
                485                 490                 495     
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys
            500                 505                 510         
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu
        515                 520                 525             
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro
    530                 535                 540                 
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly
545                 550                 555                 560 
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro
                565                 570                 575     
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly
            580                 585                 590         
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu
        595                 600                 605             
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly
    610                 615                 620                 
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr
625                 630                 635                 640 
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys
                645                 650                 655     
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser
            660                 665                 670         
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly
        675                 680                 685             
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys
    690                 695                 700                 
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu
705                 710                 715                 720 
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys
                725                 730                 735     
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly
            740                 745                 750         
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu
        755                 760                 765             
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu
    770                 775                 780                 
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg
785                 790                 795                 800 
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val
                805                 810                 815     
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu
            820                 825                 830         
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu
        835                 840                 845             
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu
    850                 855                 860                 
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp
865                 870                 875                 880 
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro
                885                 890                 895     
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His
            900                 905                 910         
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp
        915                 920                 925             
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val
    930                 935                 940                 
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu
945                 950                 955                 960 
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg
                965                 970                 975     
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val
            980                 985                 990         
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala
        995                 1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Glu His Leu Val Asn Gly Arg
                1365                1370                1375    
Met Asp Phe Ala Phe Pro Gly Ser Thr Asn Ser Leu His Arg Met Thr
            1380                1385                1390        
Thr Thr Ser Ala Ala Ala Tyr Gly Thr His Leu Ser Pro His Val Pro
        1395                1400                1405            
His Arg Val Leu Ser Thr Ser Ser Thr Leu Thr Arg Asp Tyr Asn Ser
    1410                1415                1420                
Leu Thr Arg Ser Glu His Ser His Ser Thr Thr Leu Pro Arg Asp Tyr
1425                1430                1435                1440
Ser Thr Leu Thr Ser Val Ser Ser His Asp Ser Arg Leu Thr Ala Gly
                1445                1450                1455    
Val Pro Asp Thr Pro Thr Arg Leu Val Phe Ser Ala Leu Gly Pro Thr
            1460                1465                1470        
Ser Leu Arg Val Ser Trp Gln Glu Pro Arg Cys Glu Arg Pro Leu Gln
        1475                1480                1485            
Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn Gly Gly Glu Leu His Arg
    1490                1495                1500                
Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser Val Val Val Glu Asp Leu
1505                1510                1515                1520
Leu Pro Asn His Ser Tyr Val Phe Arg Val Arg Ala Gln Ser Gln Glu
                1525                1530                1535    
Gly Trp Gly Arg Glu Arg Glu Gly Val Ile Thr Ile Glu Ser Gln Val
            1540                1545                1550        
His Pro Gln Ser Pro Leu Cys Pro Leu Pro Gly Ser Ala Phe Thr Leu
        1555                1560                1565            
Ser Thr Pro Ser Ala Pro Gly Pro Leu Val Phe Thr Ala Leu Ser Pro
    1570                1575                1580                
Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro Arg Arg Pro Asn Gly Asp
1585                1590                1595                1600
Ile Val Gly Tyr Leu Val Thr Trp Pro Ala Thr Ala Phe Arg Val Asp
                1605                1610                1615    
Gly Asp Ser Pro Glu Ser Arg Leu Thr Val Pro Gly Leu Ser Glu Asn
            1620                1625                1630        
Val Pro Tyr Lys Phe Lys Val Gln Ala Arg Thr Thr Glu Gly Phe Gly
        1635                1640                1645            
Pro Glu Arg Glu Gly Ile Ile Thr Ile Glu Ser Gln Asp Gly Gly Pro
    1650                1655                1660                
Phe Pro Gln Leu Gly Ser Arg Ala Gly Leu Phe Gln His Pro Leu Gln
1665                1670                1675                1680
Ser Glu Tyr Ser Ser Ile Thr Thr Thr His Thr Ser Ala Thr Glu Pro
                1685                1690                1695    
Phe Leu Val Asp Gly Pro Thr Leu Gly Ala Gln His Leu Glu Ala Gly
            1700                1705                1710        
Gly Ser Leu Thr Arg His Val Thr Gln Glu Phe Val Ser Arg Thr Leu
        1715                1720                1725            
Thr Thr Ser Gly Thr Leu Ser Thr His Met Asp Gln Gln Phe Phe Gln
    1730                1735                1740                
Thr
1745


<210> 9130
<211> 484
<212> PRT
<213> Homo sapiens

<400> 9130
Met Ala Pro Trp Leu Gln Leu Leu Ser Leu Leu Gly Leu Leu Pro Gly
 1               5                  10                  15      
Ala Val Ala Ala Pro Ala Gln Pro Arg Ala Ala Ser Phe Gln Ala Trp
            20                  25                  30          
Gly Pro Pro Ser Pro Glu Leu Leu Ala Pro Thr Arg Phe Ala Leu Glu
        35                  40                  45              
Met Phe Asn Arg Gly Arg Ala Ala Gly Thr Arg Ala Val Leu Gly Leu
    50                  55                  60                  
Val Arg Gly Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Tyr Ser Leu
65                  70                  75                  80  
Glu Ala Thr Leu Glu Glu Pro Pro Cys Asn Asp Pro Met Val Cys Arg
                85                  90                  95      
Leu Pro Val Ser Lys Lys Thr Leu Leu Cys Ser Phe Gln Val Leu Asp
            100                 105                 110         
Glu Leu Gly Arg His Val Leu Leu Arg Lys Asp Cys Gly Pro Val Asp
        115                 120                 125             
Thr Lys Val Pro Gly Ala Gly Glu Pro Lys Ser Ala Phe Thr Gln Gly
    130                 135                 140                 
Ser Ala Met Ile Ser Ser Leu Ser Gln Asn His Pro Asp Asn Arg Asn
145                 150                 155                 160 
Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser
                165                 170                 175     
Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile
            180                 185                 190         
Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu
        195                 200                 205             
Ser Val Phe Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu
    210                 215                 220                 
Asp Arg Gly Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr
225                 230                 235                 240 
Glu Glu Glu Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu
                245                 250                 255     
Pro Gly Asn Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro
            260                 265                 270         
Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp
        275                 280                 285             
Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val
    290                 295                 300                 
Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu
305                 310                 315                 320 
Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly
                325                 330                 335     
Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu
            340                 345                 350         
Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe
        355                 360                 365             
Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser
    370                 375                 380                 
Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile
385                 390                 395                 400 
Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile
                405                 410                 415     
Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala
            420                 425                 430         
Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe Trp Ala
        435                 440                 445             
Ile Lys Asn Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr Tyr Tyr
    450                 455                 460                 
Leu His Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala Ser Ser
465                 470                 475                 480 
Ala Val Val Asp
                


<210> 9131
<211> 775
<212> PRT
<213> Homo sapiens

<400> 9131
Met Ala Ser Ala Gly His Ile Ile Thr Leu Leu Leu Trp Gly Tyr Leu
 1               5                  10                  15      
Leu Glu Leu Trp Thr Gly Gly His Thr Ala Asp Thr Thr His Pro Arg
            20                  25                  30          
Leu Arg Leu Ser His Lys Glu Leu Leu Asn Leu Asn Arg Thr Ser Ile
        35                  40                  45              
Phe His Ser Pro Phe Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp
    50                  55                  60                  
Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser
65                  70                  75                  80  
Leu Ser Leu Glu Arg Ile Ser Asp Gly Tyr Lys Glu Ile His Trp Pro
                85                  90                  95      
Ser Thr Ala Leu Lys Met Glu Glu Cys Ile Met Lys Gly Lys Asp Ala
            100                 105                 110         
Gly Glu Cys Ala Asn Tyr Val Arg Val Leu His His Tyr Asn Arg Thr
        115                 120                 125             
His Leu Leu Thr Cys Gly Thr Gly Ala Phe Asp Pro Val Cys Ala Phe
    130                 135                 140                 
Ile Arg Val Gly Tyr His Leu Glu Asp Pro Leu Phe His Leu Glu Ser
145                 150                 155                 160 
Pro Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Ser Ser
                165                 170                 175     
Ser Phe Ile Ser Thr Leu Ile Gly Ser Glu Leu Phe Ala Gly Leu Tyr
            180                 185                 190         
Ser Asp Tyr Trp Ser Arg Asp Ala Ala Ile Phe Arg Ser Met Gly Arg
        195                 200                 205             
Leu Ala His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu
    210                 215                 220                 
Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp
225                 230                 235                 240 
Asp Asn Lys Val Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu
                245                 250                 255     
Asn Asn Ala His Ala Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn
            260                 265                 270         
Asp Val Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu
        275                 280                 285             
Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr
    290                 295                 300                 
Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp His
305                 310                 315                 320 
Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe
                325                 330                 335     
Arg Gly His Ala Ile Cys Val Tyr His Met Ser Ser Ile Arg Ala Ala
            340                 345                 350         
Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser
        355                 360                 365             
Val Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser
    370                 375                 380                 
Lys Val Asn Gly Gly Arg Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp
385                 390                 395                 400 
Ala Ile Arg Phe Ala Arg Ser His Pro Leu Met Tyr Gln Ala Ile Lys
                405                 410                 415     
Pro Ala His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn
            420                 425                 430         
Leu Lys Gln Ile Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr
        435                 440                 445             
Asp Val Leu Phe Ile Gly Thr Asp Asn Gly Ile Val Leu Lys Val Ile
    450                 455                 460                 
Thr Ile Tyr Asn Gln Glu Met Glu Ser Met Glu Glu Val Ile Leu Glu
465                 470                 475                 480 
Glu Leu Gln Ile Phe Lys Asp Pro Val Pro Ile Ile Ser Met Glu Ile
                485                 490                 495     
Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala
            500                 505                 510         
Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp
        515                 520                 525             
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys
    530                 535                 540                 
Ser Arg Tyr Tyr Pro Thr Gly Thr His Ala Lys Arg Arg Phe Arg Arg
545                 550                 555                 560 
Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln
                565                 570                 575     
Phe Val Gly Asp Ala Leu Asp Lys Thr Glu Glu His Leu Ala Tyr Gly
            580                 585                 590         
Ile Glu Asn Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln
        595                 600                 605             
Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Glu Thr Arg Lys Glu
    610                 615                 620                 
Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu
625                 630                 635                 640 
Phe Leu Arg Leu His Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr
                645                 650                 655     
Val Glu His Ser Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val
            660                 665                 670         
Val Glu Glu Glu Lys Val Glu Asp Met Phe Asn Lys Asp Asp Glu Glu
        675                 680                 685             
Asp Arg His His Arg Met Pro Cys Pro Ala Gln Ser Ser Ile Ser Gln
    690                 695                 700                 
Gly Ala Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser
705                 710                 715                 720 
Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp
                725                 730                 735     
Arg Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala
            740                 745                 750         
Asn Pro Gln Glu Lys Lys Leu Arg Ser Lys Pro Glu His Tyr Arg Leu
        755                 760                 765             
Pro Arg His Thr Leu Asp Ser
    770                 775 


<210> 9132
<211> 282
<212> PRT
<213> Homo sapiens

<400> 9132
Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu
 1               5                  10                  15      
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Glu Pro
            20                  25                  30          
Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp Ser Pro Val Leu
        35                  40                  45              
Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His Thr Leu Thr
    50                  55                  60                  
Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser Ala Thr Arg Lys
65                  70                  75                  80  
Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg Ala Glu Asp
                85                  90                  95      
Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala Pro Lys Ala
            100                 105                 110         
Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr Gly His Lys
        115                 120                 125             
Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr Met Tyr Cys Lys
    130                 135                 140                 
Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg Lys Lys Glu Asn
145                 150                 155                 160 
Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg Phe Phe Ile Ile
                165                 170                 175     
Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu Gln Ile Thr
            180                 185                 190         
Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ala Ile Gly Ser
        195                 200                 205             
Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His Leu Ala Pro Leu
    210                 215                 220                 
Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu Val Val Ile
225                 230                 235                 240 
Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val Pro Asp Asp
                245                 250                 255     
Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys
            260                 265                 270         
Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn
        275                 280         


<210> 9133
<211> 398
<212> PRT
<213> Homo sapiens

<400> 9133
Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu
 1               5                  10                  15      
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly
            20                  25                  30          
Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe
        35                  40                  45              
Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp
    50                  55                  60                  
Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp
65                  70                  75                  80  
Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn
                85                  90                  95      
Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly
            100                 105                 110         
Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg
        115                 120                 125             
Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val
    130                 135                 140                 
Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp
145                 150                 155                 160 
Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser
                165                 170                 175     
His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser
            180                 185                 190         
Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro
        195                 200                 205             
Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser
    210                 215                 220                 
Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile
225                 230                 235                 240 
Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr
                245                 250                 255     
Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg
            260                 265                 270         
Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg
        275                 280                 285             
Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn
    290                 295                 300                 
Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn
305                 310                 315                 320 
Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His
                325                 330                 335     
Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile
            340                 345                 350         
Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu
        355                 360                 365             
Val Pro Asp Asp Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr
    370                 375                 380                 
Asn Asn His Lys Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn
385                 390                 395             


<210> 9134
<211> 315
<212> PRT
<213> Homo sapiens

<400> 9134
Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg
 1               5                  10                  15      
Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser
            20                  25                  30          
Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val
        35                  40                  45              
Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn
    50                  55                  60                  
Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu
65                  70                  75                  80  
Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala
                85                  90                  95      
Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu
            100                 105                 110         
Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly
        115                 120                 125             
Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu
    130                 135                 140                 
Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro
145                 150                 155                 160 
Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp
                165                 170                 175     
Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys
            180                 185                 190         
Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly
        195                 200                 205             
Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys
    210                 215                 220                 
Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile
225                 230                 235                 240 
Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser
                245                 250                 255     
Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val Arg
            260                 265                 270         
Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp His
        275                 280                 285             
Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu Val
    290                 295                 300                 
Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala
305                 310                 315 


<210> 9135
<211> 476
<212> PRT
<213> Homo sapiens

<400> 9135
Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val Leu Ile Leu Asn Leu
 1               5                  10                  15      
Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala
            20                  25                  30          
Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro
        35                  40                  45              
Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn
    50                  55                  60                  
Glu Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe
65                  70                  75                  80  
Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile
                85                  90                  95      
Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr
            100                 105                 110         
Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg
        115                 120                 125             
Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser
    130                 135                 140                 
Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln
145                 150                 155                 160 
Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro
                165                 170                 175     
Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln
            180                 185                 190         
Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His
        195                 200                 205             
Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu
    210                 215                 220                 
Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr
225                 230                 235                 240 
Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro
                245                 250                 255     
Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile
            260                 265                 270         
Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala
        275                 280                 285             
Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr
    290                 295                 300                 
Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala
305                 310                 315                 320 
Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr
                325                 330                 335     
Asp Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn
            340                 345                 350         
Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr
        355                 360                 365             
Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys
    370                 375                 380                 
Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro
385                 390                 395                 400 
Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly
                405                 410                 415     
Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val
            420                 425                 430         
Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp
        435                 440                 445             
His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu
    450                 455                 460                 
Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala
465                 470                 475     


<210> 9136
<211> 368
<212> PRT
<213> Homo sapiens

<400> 9136
Met Val Ser Thr Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile
 1               5                  10                  15      
Lys Phe Leu Arg Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu
            20                  25                  30          
Tyr Pro Gly Ser Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr
        35                  40                  45              
Val Leu Val Gln Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln
    50                  55                  60                  
Ile Asn Lys Pro Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile
65                  70                  75                  80  
Ser Asn Ile Gln Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu
                85                  90                  95      
Asp Tyr Ile His Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly
            100                 105                 110         
Tyr Thr Gly Glu Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly
        115                 120                 125             
Ser Asn Ala Tyr Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp
    130                 135                 140                 
Asn Gly Ala Pro Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly
145                 150                 155                 160 
His Asn Phe Ile Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro
                165                 170                 175     
Thr Ser Gly Ala Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile
            180                 185                 190         
Trp Ala Tyr Tyr Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln
        195                 200                 205             
Gly Trp Asp Ala Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val
    210                 215                 220                 
Trp Val Gly Tyr Asp Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp
225                 230                 235                 240 
Leu Lys His Asn Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu
                245                 250                 255     
Asp Asp Phe Thr Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile
            260                 265                 270         
Ser Thr Leu Lys Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala
        275                 280                 285             
Pro Ala Gln Pro Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly
    290                 295                 300                 
Asn Gly Ser Gly Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly
305                 310                 315                 320 
Phe Cys Ala Val Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg
                325                 330                 335     
Asn Ala Phe Trp His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys
            340                 345                 350         
Gln Ala Gly Leu Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala
        355                 360                 365             


<210> 9137
<211> 534
<212> PRT
<213> Homo sapiens

<400> 9137
Met Ala Thr Gly Leu Gln Val Pro Leu Pro Gln Leu Ala Thr Gly Leu
 1               5                  10                  15      
Leu Leu Leu Leu Ser Val Gln Pro Trp Ala Glu Ser Gly Lys Val Leu
            20                  25                  30          
Val Val Pro Thr Asp Gly Ser His Trp Leu Ser Met Arg Glu Ala Leu
        35                  40                  45              
Arg Asp Leu His Ala Arg Gly His Gln Val Val Val Leu Thr Leu Glu
    50                  55                  60                  
Val Asn Met Tyr Ile Lys Glu Glu Asn Phe Phe Thr Leu Thr Thr Tyr
65                  70                  75                  80  
Ala Ile Ser Trp Thr Gln Asp Glu Phe Asp Arg Leu Leu Leu Gly His
                85                  90                  95      
Thr Gln Ser Phe Phe Glu Thr Glu His Leu Leu Met Lys Phe Ser Arg
            100                 105                 110         
Arg Met Ala Ile Met Asn Asn Met Ser Leu Ile Ile His Arg Ser Cys
        115                 120                 125             
Val Glu Leu Leu His Asn Glu Ala Leu Ile Arg His Leu His Ala Thr
    130                 135                 140                 
Ser Phe Asp Val Val Leu Thr Asp Pro Phe His Leu Cys Ala Ala Val
145                 150                 155                 160 
Leu Ala Lys Tyr Leu Ser Ile Pro Ala Val Phe Phe Leu Arg Asn Ile
                165                 170                 175     
Pro Cys Asp Leu Asp Phe Lys Gly Thr Gln Cys Pro Asn Pro Ser Ser
            180                 185                 190         
Tyr Ile Pro Arg Leu Leu Thr Thr Asn Ser Asp His Met Thr Phe Leu
        195                 200                 205             
Gln Arg Val Lys Asn Met Leu Tyr Pro Leu Ala Leu Ser Tyr Leu Cys
    210                 215                 220                 
His Ala Val Ser Ala Pro Tyr Ala Ser Leu Ala Ser Glu Leu Phe Gln
225                 230                 235                 240 
Arg Glu Val Ser Val Val Asp Leu Val Ser His Ala Ser Val Trp Leu
                245                 250                 255     
Phe Arg Gly Asp Phe Val Met Asp Tyr Pro Arg Pro Ile Met Pro Asn
            260                 265                 270         
Met Val Phe Ile Gly Gly Ile Asn Cys Ala Asn Gly Lys Pro Leu Ser
        275                 280                 285             
Gln Glu Phe Glu Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val
    290                 295                 300                 
Val Phe Ser Leu Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala
305                 310                 315                 320 
Met Ala Ile Ala Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp
                325                 330                 335     
Arg Tyr Thr Gly Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu
            340                 345                 350         
Val Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg
        355                 360                 365             
Ala Phe Ile Thr His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys
    370                 375                 380                 
Asn Gly Val Pro Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp
385                 390                 395                 400 
Asn Ala Lys Arg Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val
                405                 410                 415     
Leu Glu Met Thr Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile
            420                 425                 430         
Asn Asp Lys Ser Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His
        435                 440                 445             
Lys Asp Arg Pro Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu
    450                 455                 460                 
Phe Val Met Arg His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His
465                 470                 475                 480 
Asp Leu Thr Trp Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu
                485                 490                 495     
Leu Ala Val Val Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala
            500                 505                 510         
Tyr Gly Tyr Arg Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala
        515                 520                 525             
His Lys Ser Lys Thr His
    530                 


<210> 9138
<211> 218
<212> PRT
<213> Homo sapiens

<400> 9138
Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln Glu Asp Thr Gly Ser
 1               5                  10                  15      
Tyr Thr Leu His Ile Ile Lys Arg Gly Asp Gly Thr Gly Gly Val Thr
            20                  25                  30          
Gly Arg Phe Thr Phe Thr Leu Tyr Leu Glu Thr Pro Lys Pro Ser Ile
        35                  40                  45              
Ser Ser Ser Asn Phe Asn Pro Arg Glu Ala Thr Glu Ala Val Ile Leu
    50                  55                  60                  
Thr Cys Asp Pro Glu Thr Pro Asp Ala Ser Tyr Leu Trp Trp Met Asn
65                  70                  75                  80  
Gly Gln Ser Leu Pro Met Thr His Ser Leu Gln Leu Ser Glu Thr Asn
                85                  90                  95      
Arg Thr Leu Tyr Leu Phe Gly Val Thr Asn Tyr Thr Ala Gly Pro Tyr
            100                 105                 110         
Glu Cys Glu Ile Arg Asn Pro Val Ser Ala Ser Arg Ser Asp Pro Val
        115                 120                 125             
Thr Leu Asn Leu Leu His Gly Pro Asp Leu Pro Arg Ile Tyr Pro Ser
    130                 135                 140                 
Phe Thr Tyr Tyr His Ser Gly Gln Asn Leu Tyr Leu Ser Cys Phe Ala
145                 150                 155                 160 
Asp Ser Asn Pro Pro Ala Gln Tyr Ser Trp Thr Ile Asn Gly Lys Phe
                165                 170                 175     
Gln Leu Ser Gly Gln Lys Leu Ser Ile Pro Gln Ile Thr Thr Lys His
            180                 185                 190         
Ser Gly Leu Tyr Ala Cys Ser Val Arg Asn Ser Ala Thr Gly Lys Glu
        195                 200                 205             
Ser Ser Lys Ser Val Thr Val Arg Val Ser
    210                 215             


<210> 9139
<211> 419
<212> PRT
<213> Homo sapiens

<400> 9139
Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln His Ile Thr Trp Lys
 1               5                  10                  15      
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
            20                  25                  30          
Thr Ala Gln Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly
        35                  40                  45              
Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Thr Gly
    50                  55                  60                  
Tyr Ile Trp Tyr Lys Gly Gln Ile Arg Asp Leu Tyr His Tyr Val Thr
65                  70                  75                  80  
Ser Tyr Val Val Asp Gly Gln Ile Ile Lys Tyr Gly Pro Ala Tyr Ser
                85                  90                  95      
Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110         
Thr Gln Glu Asp Thr Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Gly
        115                 120                 125             
Asp Gly Thr Gly Gly Val Thr Gly Arg Phe Thr Phe Thr Leu Tyr Leu
    130                 135                 140                 
Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Phe Asn Pro Arg Glu
145                 150                 155                 160 
Ala Thr Glu Ala Val Ile Leu Thr Cys Asp Pro Glu Thr Pro Asp Ala
                165                 170                 175     
Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Ser
            180                 185                 190         
Leu Gln Leu Ser Glu Thr Asn Arg Thr Leu Tyr Leu Phe Gly Val Thr
        195                 200                 205             
Asn Tyr Thr Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser
    210                 215                 220                 
Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro
225                 230                 235                 240 
Lys Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp
                245                 250                 255     
Val Ser Thr Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile
            260                 265                 270         
Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Arg
        275                 280                 285             
Arg Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu
    290                 295                 300                 
Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Ile Arg
305                 310                 315                 320 
Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Arg
                325                 330                 335     
Ile Tyr Pro Ser Phe Thr Tyr Tyr His Ser Gly Gln Asn Leu Tyr Leu
            340                 345                 350         
Ser Cys Phe Ala Asp Ser Asn Pro Pro Ala Gln Tyr Ser Trp Thr Ile
        355                 360                 365             
Asn Gly Lys Phe Gln Leu Ser Gly Gln Lys Leu Ser Ile Pro Gln Ile
    370                 375                 380                 
Thr Thr Lys His Ser Gly Leu Tyr Ala Cys Ser Val Arg Asn Ser Ala
385                 390                 395                 400 
Thr Gly Lys Glu Ser Ser Lys Ser Val Thr Val Arg Val Ser Asp Trp
                405                 410                 415     
Thr Leu Pro
            


<210> 9140
<211> 1230
<212> PRT
<213> Homo sapiens

<400> 9140
Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val
 1               5                  10                  15      
Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp
            20                  25                  30          
Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu
        35                  40                  45              
Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met
    50                  55                  60                  
Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu
65                  70                  75                  80  
Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln
                85                  90                  95      
His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg
            100                 105                 110         
Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val
        115                 120                 125             
Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu
    130                 135                 140                 
Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln
145                 150                 155                 160 
Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys
                165                 170                 175     
Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala
            180                 185                 190         
Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr
        195                 200                 205             
Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser
    210                 215                 220                 
Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val
225                 230                 235                 240 
Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu
                245                 250                 255     
Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr
            260                 265                 270         
Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu
        275                 280                 285             
Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr
    290                 295                 300                 
Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro
305                 310                 315                 320 
Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala
                325                 330                 335     
Thr Ala Gly Asp Pro Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro
            340                 345                 350         
Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp
        355                 360                 365             
Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser
    370                 375                 380                 
Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg
385                 390                 395                 400 
Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala
                405                 410                 415     
Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro
            420                 425                 430         
Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn
        435                 440                 445             
Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala
    450                 455                 460                 
Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg
465                 470                 475                 480 
Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr
                485                 490                 495     
Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys
            500                 505                 510         
Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys
        515                 520                 525             
Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly
    530                 535                 540                 
Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp
545                 550                 555                 560 
Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu
                565                 570                 575     
Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val
            580                 585                 590         
Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala
        595                 600                 605             
Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser
    610                 615                 620                 
Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu
625                 630                 635                 640 
Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu
                645                 650                 655     
Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp
            660                 665                 670         
Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly
        675                 680                 685             
Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu
    690                 695                 700                 
Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn
705                 710                 715                 720 
Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp
                725                 730                 735     
Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile
            740                 745                 750         
Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys
        755                 760                 765             
Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe
    770                 775                 780                 
Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val
785                 790                 795                 800 
Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg
                805                 810                 815     
Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser
            820                 825                 830         
Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile
        835                 840                 845             
Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly
    850                 855                 860                 
Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser
865                 870                 875                 880 
Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val
                885                 890                 895     
Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys
            900                 905                 910         
Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp
        915                 920                 925             
Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe
    930                 935                 940                 
Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg
945                 950                 955                 960 
Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu
                965                 970                 975     
Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp
            980                 985                 990         
Ile Phe Val Arg Gly Trp Leu Lys Gly Gln Gln Glu Asp Lys Gln Asp
        995                 1000                1005            
Thr Asp Val His Tyr His Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp
    1010                1015                1020                
Arg Tyr Leu Phe Pro Phe Asp Tyr Leu Ala Ala Glu Glu Lys Ile Val
1025                1030                1035                1040
Ile Ser Lys Lys Glu Ser Met Phe Ser Trp Asp Glu Thr Glu Tyr Lys
                1045                1050                1055    
Ile Pro Ala Arg Leu Thr Leu Gln Ile Trp Asp Ala Asp His Phe Ser
            1060                1065                1070        
Ala Asp Asp Phe Leu Gly Ala Ile Glu Leu Asp Leu Asn Arg Phe Pro
        1075                1080                1085            
Arg Gly Ala Lys Thr Ala Lys Gln Cys Thr Met Glu Met Ala Thr Gly
    1090                1095                1100                
Glu Val Asp Val Pro Leu Val Ser Ile Phe Lys Gln Lys Arg Val Lys
1105                1110                1115                1120
Gly Trp Trp Pro Leu Leu Ala Arg Asn Glu Asn Asp Glu Phe Glu Leu
                1125                1130                1135    
Thr Gly Lys Val Glu Ala Glu Leu His Leu Leu Thr Ala Glu Glu Ala
            1140                1145                1150        
Glu Lys Asn Pro Val Gly Leu Ala Arg Asn Glu Pro Asp Pro Leu Glu
        1155                1160                1165            
Lys Pro Asn Arg Pro Asp Thr Ala Phe Val Trp Phe Leu Asn Pro Leu
    1170                1175                1180                
Lys Ser Ile Lys Tyr Leu Ile Cys Thr Arg Tyr Lys Trp Leu Ile Ile
1185                1190                1195                1200
Lys Ile Val Leu Ala Leu Leu Gly Leu Leu Met Leu Gly Leu Phe Leu
                1205                1210                1215    
Tyr Ser Leu Pro Gly Tyr Met Val Lys Lys Leu Leu Gly Ala
            1220                1225                1230


<210> 9141
<211> 1230
<212> PRT
<213> Homo sapiens

<400> 9141
Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val
 1               5                  10                  15      
Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp
            20                  25                  30          
Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu
        35                  40                  45              
Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met
    50                  55                  60                  
Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu
65                  70                  75                  80  
Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln
                85                  90                  95      
His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg
            100                 105                 110         
Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val
        115                 120                 125             
Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu
    130                 135                 140                 
Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln
145                 150                 155                 160 
Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys
                165                 170                 175     
Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala
            180                 185                 190         
Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr
        195                 200                 205             
Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser
    210                 215                 220                 
Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val
225                 230                 235                 240 
Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu
                245                 250                 255     
Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr
            260                 265                 270         
Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu
        275                 280                 285             
Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr
    290                 295                 300                 
Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro
305                 310                 315                 320 
Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala
                325                 330                 335     
Thr Ala Gly Asp Pro Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro
            340                 345                 350         
Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp
        355                 360                 365             
Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser
    370                 375                 380                 
Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg
385                 390                 395                 400 
Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala
                405                 410                 415     
Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro
            420                 425                 430         
Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn
        435                 440                 445             
Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala
    450                 455                 460                 
Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg
465                 470                 475                 480 
Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr
                485                 490                 495     
Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys
            500                 505                 510         
Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys
        515                 520                 525             
Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly
    530                 535                 540                 
Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp
545                 550                 555                 560 
Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu
                565                 570                 575     
Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val
            580                 585                 590         
Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala
        595                 600                 605             
Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser
    610                 615                 620                 
Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu
625                 630                 635                 640 
Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu
                645                 650                 655     
Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp
            660                 665                 670         
Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly
        675                 680                 685             
Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu
    690                 695                 700                 
Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn
705                 710                 715                 720 
Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp
                725                 730                 735     
Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile
            740                 745                 750         
Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys
        755                 760                 765             
Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe
    770                 775                 780                 
Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val
785                 790                 795                 800 
Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg
                805                 810                 815     
Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser
            820                 825                 830         
Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile
        835                 840                 845             
Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly
    850                 855                 860                 
Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser
865                 870                 875                 880 
Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val
                885                 890                 895     
Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys
            900                 905                 910         
Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp
        915                 920                 925             
Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe
    930                 935                 940                 
Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg
945                 950                 955                 960 
Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu
                965                 970                 975     
Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp
            980                 985                 990         
Ile Phe Val Arg Gly Trp Leu Lys Gly Gln Gln Glu Asp Lys Gln Asp
        995                 1000                1005            
Thr Asp Val His Tyr His Ser Leu Thr Gly Glu Gly Asn Phe Asn Trp
    1010                1015                1020                
Arg Tyr Leu Phe Pro Phe Asp Tyr Leu Ala Ala Glu Glu Lys Ile Val
1025                1030                1035                1040
Ile Ser Lys Lys Glu Ser Met Phe Ser Trp Asp Glu Thr Glu Tyr Lys
                1045                1050                1055    
Ile Pro Ala Arg Leu Thr Leu Gln Ile Trp Asp Ala Asp His Phe Ser
            1060                1065                1070        
Ala Asp Asp Phe Leu Gly Ala Ile Glu Leu Asp Leu Asn Arg Phe Pro
        1075                1080                1085            
Arg Gly Ala Lys Thr Ala Lys Gln Cys Thr Met Glu Met Ala Thr Gly
    1090                1095                1100                
Glu Val Asp Val Pro Leu Val Ser Ile Phe Lys Gln Lys Arg Val Lys
1105                1110                1115                1120
Gly Trp Trp Pro Leu Leu Ala Arg Asn Glu Asn Asp Glu Phe Glu Leu
                1125                1130                1135    
Thr Gly Lys Val Glu Ala Glu Leu His Leu Leu Thr Ala Glu Glu Ala
            1140                1145                1150        
Glu Lys Asn Pro Val Gly Leu Ala Arg Asn Glu Pro Asp Pro Leu Glu
        1155                1160                1165            
Lys Pro Asn Arg Pro Asp Thr Ser Phe Ile Trp Phe Leu Asn Pro Leu
    1170                1175                1180                
Lys Ser Ala Arg Tyr Phe Leu Trp His Thr Tyr Arg Trp Leu Leu Leu
1185                1190                1195                1200
Lys Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Leu Phe Leu
                1205                1210                1215    
Tyr Ser Val Pro Gly Tyr Leu Val Lys Lys Ile Leu Gly Ala
            1220                1225                1230


<210> 9142
<211> 694
<212> PRT
<213> Homo sapiens

<400> 9142
Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu
            20                  25                  30          
Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr
        35                  40                  45              
Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu
    50                  55                  60                  
Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys
65                  70                  75                  80  
Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys
                85                  90                  95      
Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu
            100                 105                 110         
Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala
        115                 120                 125             
Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro
    130                 135                 140                 
Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala
145                 150                 155                 160 
Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro Gly Glu Gln Pro
                165                 170                 175     
Pro Ser Gly Ser Gly His Gly Arg Pro Pro Gly Ala Arg Pro Pro His
            180                 185                 190         
Arg Gly Gly Gly Arg Gly Gly Gly Gly Gly Asp Ala Ala Ala Pro Pro
        195                 200                 205             
Ala Arg Gly Gly Gly Gly Gly Gly Lys Ala Arg Pro Pro Gly Gly Gly
    210                 215                 220                 
Ala Ala Pro Cys Glu Pro Gly Cys Gln Cys Arg Ala Pro Met Val Ser
225                 230                 235                 240 
Val Ser Ser Glu Arg His Pro Leu Tyr Asn Arg Val Lys Thr Gly Gln
                245                 250                 255     
Ile Ala Asn Cys Ala Leu Pro Cys His Asn Pro Phe Phe Ser Gln Asp
            260                 265                 270         
Glu Arg Ala Phe Thr Val Phe Trp Ile Gly Leu Trp Ser Val Leu Cys
        275                 280                 285             
Phe Val Ser Thr Phe Ala Thr Val Ser Thr Phe Leu Ile Asp Met Glu
    290                 295                 300                 
Arg Phe Lys Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Ala Cys Tyr
305                 310                 315                 320 
Leu Phe Val Ser Val Gly Tyr Leu Val Arg Leu Val Ala Gly His Glu
                325                 330                 335     
Lys Val Ala Cys Ser Gly Gly Ala Pro Gly Ala Gly Gly Ala Gly Gly
            340                 345                 350         
Ala Gly Gly Ala Ala Ala Gly Ala Gly Ala Ala Gly Ala Gly Ala Gly
        355                 360                 365             
Gly Pro Gly Gly Arg Gly Glu Tyr Glu Glu Leu Gly Ala Val Glu Gln
    370                 375                 380                 
His Val Arg Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Val Val Phe
385                 390                 395                 400 
Leu Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile
                405                 410                 415     
Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu
            420                 425                 430         
Ala Ile Ala Gly Tyr Ser Gln Tyr Phe His Leu Ala Ala Trp Leu Val
        435                 440                 445             
Pro Ser Val Lys Ser Ile Ala Val Leu Ala Leu Ser Ser Val Asp Gly
    450                 455                 460                 
Asp Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Ser Leu Asp Asn
465                 470                 475                 480 
Leu Arg Gly Phe Val Leu Ala Pro Leu Val Ile Tyr Leu Phe Ile Gly
                485                 490                 495     
Thr Met Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser
            500                 505                 510         
Val Ile Lys Gln Gln Asp Gly Pro Thr Lys Thr His Lys Leu Glu Lys
        515                 520                 525             
Leu Met Ile Arg Leu Gly Leu Phe Thr Val Leu Tyr Thr Val Pro Ala
    530                 535                 540                 
Ala Val Val Val Ala Cys Leu Phe Tyr Glu Gln His Asn Arg Pro Arg
545                 550                 555                 560 
Trp Glu Ala Thr His Asn Cys Pro Cys Leu Arg Asp Leu Gln Pro Asp
                565                 570                 575     
Gln Ala Arg Arg Pro Asp Tyr Ala Val Phe Met Leu Lys Tyr Phe Met
            580                 585                 590         
Cys Leu Val Val Gly Ile Thr Ser Gly Val Trp Val Trp Ser Gly Lys
        595                 600                 605             
Thr Leu Glu Ser Trp Arg Ser Leu Cys Thr Arg Cys Cys Trp Ala Ser
    610                 615                 620                 
Lys Gly Ala Ala Val Gly Gly Gly Ala Gly Ala Thr Ala Ala Gly Gly
625                 630                 635                 640 
Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly
                645                 650                 655     
Gly Pro Gly Gly Gly Gly Gly Ser Leu Tyr Ser Asp Val Ser Thr Gly
            660                 665                 670         
Leu Thr Trp Arg Ser Gly Thr Ala Ser Ser Val Ser Tyr Pro Lys Gln
        675                 680                 685             
Met Pro Leu Ser Gln Val
    690                 


<210> 9143
<211> 484
<212> PRT
<213> Homo sapiens

<400> 9143
Met Ala Cys Arg Gly Gly Ala Gly Asn Gly His Arg Ala Ser Ala Thr
 1               5                  10                  15      
Leu Ser Arg Val Ser Pro Gly Ser Leu Tyr Thr Cys Arg Thr Arg Thr
            20                  25                  30          
His Asn Ile Cys Met Val Ser Asp Phe Phe Tyr Pro Asn Met Gly Gly
        35                  40                  45              
Val Glu Ser His Ile Tyr Gln Leu Ser Gln Cys Leu Ile Glu Arg Gly
    50                  55                  60                  
His Lys Val Ile Ile Val Thr His Ala Tyr Gly Asn Arg Lys Gly Ile
65                  70                  75                  80  
Arg Tyr Leu Thr Ser Gly Leu Lys Val Tyr Tyr Leu Pro Leu Lys Val
                85                  90                  95      
Met Tyr Asn Gln Ser Thr Ala Thr Thr Leu Phe His Ser Leu Pro Leu
            100                 105                 110         
Leu Arg Tyr Ile Phe Val Arg Glu Arg Val Thr Ile Ile His Ser His
        115                 120                 125             
Ser Ser Phe Ser Ala Met Ala His Asp Ala Leu Phe His Ala Lys Thr
    130                 135                 140                 
Met Gly Leu Gln Thr Val Phe Thr Asp His Ser Leu Phe Gly Phe Ala
145                 150                 155                 160 
Asp Val Ser Ser Val Leu Thr Asn Lys Leu Leu Thr Val Ser Leu Cys
                165                 170                 175     
Asp Thr Asn His Ile Ile Cys Val Ser Tyr Thr Ser Lys Glu Asn Thr
            180                 185                 190         
Val Leu Arg Ala Ala Leu Asn Pro Glu Ile Val Ser Val Ile Pro Asn
        195                 200                 205             
Ala Val Asp Pro Thr Asp Phe Thr Pro Asp Pro Phe Arg Arg His Asp
    210                 215                 220                 
Ser Ile Thr Ile Val Val Val Ser Arg Leu Val Tyr Arg Lys Gly Ile
225                 230                 235                 240 
Asp Leu Leu Ser Gly Ile Ile Pro Glu Leu Cys Gln Lys Tyr Pro Asp
                245                 250                 255     
Leu Asn Phe Ile Ile Gly Gly Glu Gly Pro Lys Arg Ile Ile Leu Glu
            260                 265                 270         
Glu Val Arg Glu Arg Tyr Gln Leu His Asp Arg Val Arg Leu Leu Gly
        275                 280                 285             
Ala Leu Glu His Lys Asp Val Arg Asn Val Leu Val Gln Gly His Ile
    290                 295                 300                 
Phe Leu Asn Thr Ser Leu Thr Glu Ala Phe Cys Met Ala Ile Val Glu
305                 310                 315                 320 
Ala Ala Ser Cys Gly Leu Gln Val Val Ser Thr Arg Val Gly Gly Ile
                325                 330                 335     
Pro Glu Val Leu Pro Glu Asn Leu Ile Ile Leu Cys Glu Pro Ser Val
            340                 345                 350         
Lys Ser Leu Cys Glu Gly Leu Glu Lys Ala Ile Phe Gln Leu Lys Ser
        355                 360                 365             
Gly Thr Leu Pro Ala Pro Glu Asn Ile His Asn Ile Val Lys Thr Phe
    370                 375                 380                 
Tyr Thr Trp Arg Asn Val Ala Glu Arg Thr Glu Lys Val Tyr Asp Arg
385                 390                 395                 400 
Val Ser Val Glu Ala Val Leu Pro Met Asp Lys Arg Leu Asp Arg Leu
                405                 410                 415     
Ile Ser His Cys Gly Pro Val Thr Gly Tyr Ile Phe Ala Leu Leu Ala
            420                 425                 430         
Val Phe Asn Phe Leu Phe Leu Ile Phe Leu Arg Trp Met Thr Pro Asp
        435                 440                 445             
Ser Ile Ile Asp Val Ala Ile Asp Ala Thr Gly Pro Arg Gly Ala Trp
    450                 455                 460                 
Thr Asn Asn Tyr Ser His Ser Lys Arg Gly Gly Glu Asn Asn Glu Ile
465                 470                 475                 480 
Ser Glu Thr Arg
                


<210> 9144
<211> 578
<212> PRT
<213> Homo sapiens

<400> 9144
Met Ala Val Ser Trp Arg Ser Trp Leu Ala Asn Glu Gly Val Lys His
 1               5                  10                  15      
Leu Cys Leu Phe Ile Trp Leu Ser Met Asn Val Leu Leu Phe Trp Lys
            20                  25                  30          
Thr Phe Leu Leu Tyr Asn Gln Gly Pro Glu Tyr His Tyr Leu His Gln
        35                  40                  45              
Met Leu Gly Leu Gly Leu Cys Leu Ser Arg Ala Ser Ala Ser Val Leu
    50                  55                  60                  
Asn Leu Asn Cys Ser Leu Ile Leu Leu Pro Met Cys Arg Thr Leu Leu
65                  70                  75                  80  
Ala Tyr Leu Arg Gly Ser Gln Lys Val Pro Ser Arg Arg Thr Arg Arg
                85                  90                  95      
Leu Leu Asp Lys Ser Arg Thr Phe His Ile Thr Cys Gly Val Thr Ile
            100                 105                 110         
Cys Ile Phe Ser Gly Val His Val Ala Ala His Leu Val Asn Ala Leu
        115                 120                 125             
Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe Val Glu Leu Asn Ala Ala
    130                 135                 140                 
Arg Tyr Arg Asp Glu Asp Pro Arg Lys Leu Leu Phe Thr Thr Val Pro
145                 150                 155                 160 
Gly Leu Thr Gly Val Cys Met Val Val Val Leu Phe Leu Met Ile Thr
                165                 170                 175     
Ala Ser Thr Tyr Ala Ile Arg Val Ser Asn Tyr Asp Ile Phe Trp Tyr
            180                 185                 190         
Thr His Asn Leu Phe Phe Val Phe Tyr Met Leu Leu Thr Leu His Val
        195                 200                 205             
Ser Gly Gly Leu Leu Lys Tyr Gln Thr Asn Leu Asp Thr His Pro Pro
    210                 215                 220                 
Gly Cys Ile Ser Leu Asn Arg Thr Ser Ser Gln Asn Ile Ser Leu Pro
225                 230                 235                 240 
Glu Tyr Phe Ser Glu His Phe His Glu Pro Phe Pro Glu Gly Phe Ser
                245                 250                 255     
Lys Pro Ala Glu Phe Thr Gln His Lys Phe Val Lys Ile Cys Met Glu
            260                 265                 270         
Glu Pro Arg Phe Gln Ala Asn Phe Pro Gln Thr Trp Leu Trp Ile Ser
        275                 280                 285             
Gly Pro Leu Cys Leu Tyr Cys Ala Glu Arg Leu Tyr Arg Tyr Ile Arg
    290                 295                 300                 
Ser Asn Lys Pro Val Thr Ile Ile Ser Val Ile Ser His Pro Ser Asp
305                 310                 315                 320 
Val Met Glu Ile Arg Met Val Lys Glu Asn Phe Lys Ala Arg Pro Gly
                325                 330                 335     
Gln Tyr Ile Thr Leu His Cys Pro Ser Val Ser Ala Leu Glu Asn His
            340                 345                 350         
Pro Phe Thr Leu Thr Met Cys Pro Thr Glu Thr Lys Ala Thr Phe Gly
        355                 360                 365             
Val His Leu Lys Ile Val Gly Asp Trp Thr Glu Arg Phe Arg Asp Leu
    370                 375                 380                 
Leu Leu Pro Pro Ser Ser Gln Asp Ser Glu Ile Leu Pro Phe Ile Gln
385                 390                 395                 400 
Ser Arg Asn Tyr Pro Lys Leu Tyr Ile Asp Gly Pro Phe Gly Ser Pro
                405                 410                 415     
Phe Glu Glu Ser Leu Asn Tyr Glu Val Ser Leu Cys Val Ala Gly Gly
            420                 425                 430         
Ile Gly Val Thr Pro Phe Ala Ser Ile Leu Asn Thr Leu Leu Asp Asp
        435                 440                 445             
Trp Lys Pro Tyr Lys Leu Arg Arg Leu Tyr Phe Ile Trp Val Cys Arg
    450                 455                 460                 
Asp Ile Gln Ser Phe Arg Trp Phe Ala Asp Leu Leu Cys Met Leu His
465                 470                 475                 480 
Asn Lys Phe Trp Gln Glu Asn Arg Pro Asp Tyr Val Asn Ile Gln Leu
                485                 490                 495     
Tyr Leu Ser Gln Thr Asp Gly Ile Gln Lys Ile Ile Gly Glu Lys Tyr
            500                 505                 510         
His Ala Leu Asn Ser Arg Leu Phe Ile Gly Arg Pro Arg Trp Lys Leu
        515                 520                 525             
Leu Phe Asp Glu Ile Ala Lys Tyr Asn Arg Gly Lys Thr Val Gly Val
    530                 535                 540                 
Phe Cys Cys Gly Pro Asn Ser Leu Ser Lys Thr Leu His Lys Leu Ser
545                 550                 555                 560 
Asn Gln Asn Asn Ser Tyr Gly Thr Arg Phe Glu Tyr Asn Lys Glu Ser
                565                 570                 575     
Phe Ser
        


<210> 9145
<211> 538
<212> PRT
<213> Homo sapiens

<400> 9145
Met Ala Val Ser Trp Arg Ser Trp Leu Ala Asn Glu Gly Val Lys His
 1               5                  10                  15      
Leu Cys Leu Phe Ile Trp Leu Ser Met Asn Val Leu Leu Phe Trp Lys
            20                  25                  30          
Thr Phe Leu Leu Tyr Asn Gln Gly Pro Glu Tyr His Tyr Leu His Gln
        35                  40                  45              
Met Leu Gly Leu Gly Leu Cys Leu Ser Arg Ala Ser Ala Ser Val Leu
    50                  55                  60                  
Asn Leu Asn Cys Ser Leu Ile Leu Leu Pro Met Cys Arg Thr Leu Leu
65                  70                  75                  80  
Ala Tyr Leu Arg Gly Ser Gln Lys Val Pro Ser Arg Arg Thr Arg Arg
                85                  90                  95      
Leu Leu Asp Lys Ser Arg Thr Phe His Ile Thr Cys Gly Val Thr Ile
            100                 105                 110         
Cys Ile Phe Ser Gly Val His Val Ala Ala His Leu Val Asn Ala Leu
        115                 120                 125             
Asn Phe Ser Val Asn Tyr Ser Glu Asp Phe Val Glu Leu Asn Ala Ala
    130                 135                 140                 
Arg Tyr Arg Asp Glu Asp Pro Arg Lys Leu Leu Phe Thr Thr Val Pro
145                 150                 155                 160 
Gly Leu Thr Gly Val Cys Met Val Val Val Leu Phe Leu Met Ile Thr
                165                 170                 175     
Ala Ser Thr Tyr Ala Ile Arg Val Ser Asn Tyr Asp Ile Phe Trp Tyr
            180                 185                 190         
Thr His Asn Leu Phe Phe Val Phe Tyr Met Leu Leu Thr Leu His Val
        195                 200                 205             
Ser Gly Gly Leu Leu Lys Tyr Gln Thr Asn Leu Asp Thr His Pro Pro
    210                 215                 220                 
Gly Cys Ile Ser Leu Asn Arg Thr Ser Ser Gln Asn Ile Ser Leu Pro
225                 230                 235                 240 
Glu Tyr Phe Ser Glu His Phe His Glu Pro Phe Pro Glu Gly Phe Ser
                245                 250                 255     
Lys Pro Ala Glu Phe Thr Gln His Lys Phe Val Lys Ile Cys Met Glu
            260                 265                 270         
Glu Pro Arg Phe Gln Ala Asn Phe Pro Gln Thr Trp Leu Trp Ile Ser
        275                 280                 285             
Gly Pro Leu Cys Leu Tyr Cys Ala Glu Arg Leu Tyr Arg Tyr Ile Arg
    290                 295                 300                 
Ser Asn Lys Pro Val Thr Ile Ile Ser Val Ile Ser His Pro Ser Asp
305                 310                 315                 320 
Val Met Glu Ile Arg Met Val Lys Glu Asn Phe Lys Ala Arg Pro Gly
                325                 330                 335     
Gln Tyr Ile Thr Leu His Cys Pro Ser Val Ser Ala Leu Glu Asn His
            340                 345                 350         
Pro Phe Thr Leu Thr Met Cys Pro Thr Glu Thr Lys Ala Thr Phe Gly
        355                 360                 365             
Val His Leu Lys Ile Val Gly Asp Trp Thr Glu Arg Phe Arg Asp Leu
    370                 375                 380                 
Leu Leu Pro Pro Ser Ser Gln Asp Ser Glu Ile Leu Pro Phe Ile Gln
385                 390                 395                 400 
Ser Arg Asn Tyr Pro Lys Asp Asp Trp Lys Pro Tyr Lys Leu Arg Arg
                405                 410                 415     
Leu Tyr Phe Ile Trp Val Cys Arg Asp Ile Gln Ser Phe Arg Trp Phe
            420                 425                 430         
Ala Asp Leu Leu Cys Met Leu His Asn Lys Phe Trp Gln Glu Asn Arg
        435                 440                 445             
Pro Asp Tyr Val Asn Ile Gln Leu Tyr Leu Ser Gln Thr Asp Gly Ile
    450                 455                 460                 
Gln Lys Ile Ile Gly Glu Lys Tyr His Ala Leu Asn Ser Arg Leu Phe
465                 470                 475                 480 
Ile Gly Arg Pro Arg Trp Lys Leu Leu Phe Asp Glu Ile Ala Lys Tyr
                485                 490                 495     
Asn Arg Gly Lys Thr Val Gly Val Phe Cys Cys Gly Pro Asn Ser Leu
            500                 505                 510         
Ser Lys Thr Leu His Lys Leu Ser Asn Gln Asn Asn Ser Tyr Gly Thr
        515                 520                 525             
Arg Phe Glu Tyr Asn Lys Glu Ser Phe Ser
    530                 535             


<210> 9146
<211> 365
<212> PRT
<213> Homo sapiens

<400> 9146
Met Asn Ile Thr Asn Cys Thr Thr Glu Ala Ser Met Ala Ile Arg Pro
 1               5                  10                  15      
Lys Thr Ile Thr Glu Lys Met Leu Ile Cys Met Thr Leu Val Val Ile
            20                  25                  30          
Thr Thr Leu Thr Thr Leu Leu Asn Leu Ala Val Ile Met Ala Ile Gly
        35                  40                  45              
Thr Thr Lys Lys Leu His Gln Pro Ala Asn Tyr Leu Ile Cys Ser Leu
    50                  55                  60                  
Ala Val Thr Asp Leu Leu Val Ala Val Leu Val Met Pro Leu Ser Ile
65                  70                  75                  80  
Ile Tyr Ile Val Met Asp Arg Trp Lys Leu Gly Tyr Phe Leu Cys Glu
                85                  90                  95      
Val Trp Leu Ser Val Asp Met Thr Cys Cys Thr Cys Ser Ile Leu His
            100                 105                 110         
Leu Cys Val Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asn Ala Ile
        115                 120                 125             
Glu Tyr Ala Arg Lys Arg Thr Ala Lys Arg Ala Ala Leu Met Ile Leu
    130                 135                 140                 
Thr Val Trp Thr Ile Ser Ile Phe Ile Ser Met Pro Pro Leu Phe Trp
145                 150                 155                 160 
Arg Ser His Arg Arg Leu Ser Pro Pro Pro Ser Gln Cys Thr Ile Gln
                165                 170                 175     
His Asp His Val Ile Tyr Thr Ile Tyr Ser Thr Leu Gly Ala Phe Tyr
            180                 185                 190         
Ile Pro Leu Thr Leu Ile Leu Ile Leu Tyr Tyr Arg Ile Tyr His Ala
        195                 200                 205             
Ala Lys Ser Leu Tyr Gln Lys Arg Gly Ser Ser Arg His Leu Ser Asn
    210                 215                 220                 
Arg Ser Thr Asp Ser Gln Asn Ser Phe Ala Ser Cys Lys Leu Thr Gln
225                 230                 235                 240 
Thr Phe Cys Val Ser Asp Phe Ser Thr Ser Asp Pro Thr Thr Glu Phe
                245                 250                 255     
Glu Lys Phe His Ala Ser Ile Arg Ile Pro Pro Phe Asp Asn Asp Leu
            260                 265                 270         
Asp His Pro Gly Glu Arg Gln Gln Ile Ser Ser Thr Arg Glu Arg Lys
        275                 280                 285             
Ala Ala Arg Ile Leu Gly Leu Ile Leu Gly Ala Phe Ile Leu Ser Trp
    290                 295                 300                 
Leu Pro Phe Phe Ile Lys Glu Leu Ile Val Gly Leu Ser Ile Tyr Thr
305                 310                 315                 320 
Val Ser Ser Glu Val Ala Asp Phe Leu Thr Trp Leu Gly Tyr Val Asn
                325                 330                 335     
Ser Leu Ile Asn Pro Leu Leu Tyr Thr Ser Phe Asn Glu Asp Phe Lys
            340                 345                 350         
Leu Ala Phe Lys Lys Leu Ile Arg Cys Arg Glu His Thr
        355                 360                 365 


<210> 9147
<211> 762
<212> PRT
<213> Homo sapiens

<400> 9147
Met Ala Ser Asn Glu Arg Asp Ala Ile Ser Trp Tyr Gln Lys Lys Ile
 1               5                  10                  15      
Gly Ala Tyr Asp Gln Gln Ile Trp Glu Lys Ser Ile Glu Gln Thr Gln
            20                  25                  30          
Ile Lys Gly Leu Lys Asn Lys Pro Lys Lys Met Gly His Ile Lys Pro
        35                  40                  45              
Asp Leu Ile Asp Val Asp Leu Ile Arg Gly Ser Thr Phe Ala Lys Ala
    50                  55                  60                  
Lys Pro Glu Ile Pro Trp Thr Ser Leu Thr Arg Lys Gly Leu Val Arg
65                  70                  75                  80  
Val Val Phe Phe Pro Leu Phe Ser Asn Trp Trp Ile Gln Val Thr Ser
                85                  90                  95      
Leu Arg Ile Phe Val Trp Leu Leu Leu Leu Tyr Phe Met Gln Val Ile
            100                 105                 110         
Ala Ile Val Leu Tyr Leu Met Met Pro Ile Val Asn Ile Ser Glu Val
        115                 120                 125             
Leu Gly Pro Leu Cys Leu Met Leu Leu Met Gly Thr Val His Cys Gln
    130                 135                 140                 
Ile Val Ser Thr Gln Ile Thr Arg Pro Ser Gly Asn Asn Gly Asn Arg
145                 150                 155                 160 
Arg Arg Arg Lys Leu Arg Lys Thr Val Asn Gly Asp Gly Ser Arg Glu
                165                 170                 175     
Asn Gly Asn Asn Ser Ser Asp Lys Val Arg Gly Ile Glu Thr Leu Glu
            180                 185                 190         
Ser Val Pro Ile Ile Gly Gly Phe Trp Glu Thr Ile Phe Gly Asn Arg
        195                 200                 205             
Ile Lys Arg Val Lys Leu Ile Ser Asn Lys Gly Thr Glu Thr Asp Asn
    210                 215                 220                 
Asp Pro Ser Cys Val His Pro Ile Ile Lys Arg Arg Gln Cys Arg Pro
225                 230                 235                 240 
Glu Ile Arg Met Cys Gln Thr Arg Glu Lys Pro Lys Phe Ser Asp Gly
                245                 250                 255     
Glu Lys Cys Arg Arg Glu Ala Phe Arg Arg Leu Gly Asn Gly Val Ser
            260                 265                 270         
Asp Asp Leu Ser Ser Glu Glu Asp Gly Glu Ala Arg Thr Gln Met Ile
        275                 280                 285             
Leu Leu Arg Arg Ser Val Glu Gly Ala Ser Ser Asp Asn Gly Cys Glu
    290                 295                 300                 
Val Lys Asn Arg Lys Ser Ile Leu Ser Arg His Leu Asn Ser Gln Val
305                 310                 315                 320 
Lys Lys Thr Thr Thr Arg Trp Cys His Ile Val Arg Asp Ser Asp Ser
                325                 330                 335     
Leu Ala Glu Ser Glu Phe Glu Ser Ala Ala Phe Ser Gln Gly Ser Arg
            340                 345                 350         
Ser Gly Val Ser Gly Gly Ser Arg Ser Leu Asn Met Ser Arg Arg Asp
        355                 360                 365             
Ser Glu Ser Thr Arg His Asp Ser Glu Thr Glu Asp Met Leu Trp Asp
    370                 375                 380                 
Asp Leu Leu His Gly Pro Glu Cys Arg Ser Ser Val Thr Ser Asp Ser
385                 390                 395                 400 
Glu Gly Ala His Val Asn Thr Leu His Ser Gly Thr Lys Arg Asp Pro
                405                 410                 415     
Lys Glu Asp Val Phe Gln Gln Asn His Leu Phe Trp Leu Gln Asn Ser
            420                 425                 430         
Ser Pro Ser Ser Asp Arg Val Ser Ala Ile Ile Trp Glu Gly Asn Glu
        435                 440                 445             
Cys Lys Lys Met Asp Met Ser Val Leu Glu Ile Ser Gly Ile Ile Met
    450                 455                 460                 
Ser Arg Val Asn Ala Tyr Gln Gln Gly Val Gly Tyr Gln Met Leu Gly
465                 470                 475                 480 
Asn Val Val Thr Ile Gly Leu Ala Phe Phe Pro Phe Leu His Arg Leu
                485                 490                 495     
Phe Arg Glu Lys Ser Leu Asp Gln Leu Lys Ser Ile Ser Ala Glu Glu
            500                 505                 510         
Ile Leu Thr Leu Phe Gly Gly Ala Pro Pro Val Thr Pro Ile Ile Val
        515                 520                 525             
Trp Ser Ile Ile Asn Phe Phe Glu Arg Leu Cys Leu Thr Trp Met Phe
    530                 535                 540                 
Phe Phe Met Met Cys Val Ala Glu Arg Thr Tyr Lys Gln Arg Phe Leu
545                 550                 555                 560 
Phe Ala Lys Leu Phe Ser His Ile Thr Ser Ala Arg Lys Ala Arg Lys
                565                 570                 575     
Tyr Glu Ile Pro His Phe Arg Leu Lys Lys Val Glu Asn Ile Lys Ile
            580                 585                 590         
Trp Leu Ser Leu Arg Ser Tyr Leu Lys Arg Arg Gly Pro Gln Arg Ser
        595                 600                 605             
Val Asp Val Val Val Ser Ser Val Phe Leu Leu Thr Leu Ser Ile Ala
    610                 615                 620                 
Phe Ile Cys Cys Ala Gln Val Leu Gln Gly His Lys Thr Ser Leu Asn
625                 630                 635                 640 
Asp Ala Tyr Asn Trp Glu Phe Leu Ile Trp Glu Thr Ala Leu Leu Leu
                645                 650                 655     
Phe Leu Leu Arg Leu Ala Ser Leu Gly Ser Glu Thr Asn Lys Lys Tyr
            660                 665                 670         
Ser Asn Val Ser Ile Leu Leu Thr Glu Gln Ile Asn Leu Tyr Leu Lys
        675                 680                 685             
Met Glu Lys Lys Pro Asn Lys Lys Glu Gln Leu Thr Leu Val Asn Asn
    690                 695                 700                 
Val Leu Lys Leu Ser Thr Lys Leu Leu Lys Glu Leu Asp Thr Pro Phe
705                 710                 715                 720 
Arg Leu Tyr Gly Leu Thr Met Asn Pro Leu Ile Tyr Asn Ile Thr Arg
                725                 730                 735     
Val Val Ile Leu Ser Ala Val Ser Gly Val Ile Ser Asp Leu Leu Gly
            740                 745                 750         
Phe Asn Ile Arg Leu Trp Lys Ile Lys Ser
        755                 760         


<210> 9148
<211> 1215
<212> PRT
<213> Homo sapiens

<400> 9148
Met Gly Ala Met Ala Tyr Pro Leu Leu Leu Cys Leu Leu Leu Ala Gln
 1               5                  10                  15      
Leu Gly Leu Gly Ala Val Gly Ala Ser Arg Asp Pro Gln Gly Arg Pro
            20                  25                  30          
Asp Ser Pro Arg Glu Arg Thr Pro Lys Gly Lys Pro His Ala Gln Gln
        35                  40                  45              
Pro Gly Arg Ala Ser Ala Ser Asp Ser Ser Ala Pro Trp Ser Arg Ser
    50                  55                  60                  
Thr Asp Gly Thr Ile Leu Ala Gln Lys Leu Ala Glu Glu Val Pro Met
65                  70                  75                  80  
Asp Val Ala Ser Tyr Leu Tyr Thr Gly Asp Ser His Gln Leu Lys Arg
                85                  90                  95      
Ala Asn Cys Ser Gly Arg Tyr Glu Leu Ala Gly Leu Pro Gly Lys Trp
            100                 105                 110         
Pro Ala Leu Ala Ser Ala His Pro Ser Leu His Arg Ala Leu Asp Thr
        115                 120                 125             
Leu Thr His Ala Thr Asn Phe Leu Asn Val Met Leu Gln Ser Asn Lys
    130                 135                 140                 
Ser Arg Glu Gln Asn Leu Gln Asp Asp Leu Asp Trp Tyr Gln Ala Leu
145                 150                 155                 160 
Val Trp Ser Leu Leu Glu Gly Glu Pro Ser Ile Ser Arg Ala Ala Ile
                165                 170                 175     
Thr Phe Ser Thr Asp Ser Leu Ser Ala Pro Ala Pro Gln Val Phe Leu
            180                 185                 190         
Gln Ala Thr Arg Glu Glu Ser Arg Ile Leu Leu Gln Asp Leu Ser Ser
        195                 200                 205             
Ser Ala Pro His Leu Ala Asn Ala Thr Leu Glu Thr Glu Trp Phe His
    210                 215                 220                 
Gly Leu Arg Arg Lys Trp Arg Pro His Leu His Arg Arg Gly Pro Asn
225                 230                 235                 240 
Gln Gly Pro Arg Gly Leu Gly His Ser Trp Arg Arg Lys Asp Gly Leu
                245                 250                 255     
Gly Gly Asp Lys Ser His Phe Lys Trp Ser Pro Pro Tyr Leu Glu Cys
            260                 265                 270         
Glu Asn Gly Ser Tyr Lys Pro Gly Trp Leu Val Thr Leu Ser Ser Ala
        275                 280                 285             
Ile Tyr Gly Leu Gln Pro Asn Leu Val Pro Glu Phe Arg Gly Val Met
    290                 295                 300                 
Lys Val Asp Ile Asn Leu Gln Lys Val Asp Ile Asp Gln Cys Ser Ser
305                 310                 315                 320 
Asp Gly Trp Phe Ser Gly Thr His Lys Cys His Leu Asn Asn Ser Glu
                325                 330                 335     
Cys Met Pro Ile Lys Gly Leu Gly Phe Val Leu Gly Ala Tyr Glu Cys
            340                 345                 350         
Ile Cys Lys Ala Gly Phe Tyr His Pro Gly Val Leu Pro Val Asn Asn
        355                 360                 365             
Phe Arg Arg Arg Gly Pro Asp Gln His Ile Ser Gly Ser Thr Lys Asp
    370                 375                 380                 
Val Ser Glu Glu Ala Tyr Val Cys Leu Pro Cys Arg Glu Gly Cys Pro
385                 390                 395                 400 
Phe Cys Ala Asp Asp Ser Pro Cys Phe Val Gln Glu Asp Lys Tyr Leu
                405                 410                 415     
Arg Leu Ala Ile Ile Ser Phe Gln Ala Leu Cys Met Leu Leu Asp Phe
            420                 425                 430         
Val Ser Met Leu Val Val Tyr His Phe Arg Lys Ala Lys Ser Ile Arg
        435                 440                 445             
Ala Ser Gly Leu Ile Leu Leu Glu Thr Ile Leu Phe Gly Ser Leu Leu
    450                 455                 460                 
Leu Tyr Phe Pro Val Val Ile Leu Tyr Phe Glu Pro Ser Thr Phe Arg
465                 470                 475                 480 
Cys Ile Leu Leu Arg Trp Ala Arg Leu Leu Gly Phe Ala Thr Val Tyr
                485                 490                 495     
Gly Thr Val Thr Leu Lys Leu His Arg Val Leu Lys Val Phe Leu Ser
            500                 505                 510         
Arg Thr Ala Gln Arg Ile Pro Tyr Met Thr Gly Gly Arg Val Met Arg
        515                 520                 525             
Met Leu Ala Val Ile Leu Leu Val Val Phe Trp Phe Leu Ile Gly Trp
    530                 535                 540                 
Thr Ser Ser Val Cys Gln Asn Leu Glu Lys Gln Ile Ser Leu Ile Gly
545                 550                 555                 560 
Gln Gly Lys Thr Ser Asp His Leu Ile Phe Asn Met Cys Leu Ile Asp
                565                 570                 575     
Arg Trp Asp Tyr Met Thr Ala Val Ala Glu Phe Leu Phe Leu Leu Trp
            580                 585                 590         
Gly Val Tyr Leu Cys Tyr Ala Val Arg Thr Val Pro Ser Ala Phe His
        595                 600                 605             
Glu Pro Arg Tyr Met Ala Val Ala Val His Asn Glu Leu Ile Ile Ser
    610                 615                 620                 
Ala Ile Phe His Thr Ile Arg Phe Val Leu Ala Ser Arg Leu Gln Ser
625                 630                 635                 640 
Asp Trp Met Leu Met Leu Tyr Phe Ala His Thr His Leu Thr Val Thr
                645                 650                 655     
Val Thr Ile Gly Leu Leu Leu Ile Pro Lys Phe Ser His Ser Ser Asn
            660                 665                 670         
Asn Pro Arg Asp Asp Ile Ala Thr Glu Ala Tyr Glu Asp Glu Leu Asp
        675                 680                 685             
Met Gly Arg Ser Gly Ser Tyr Leu Asn Ser Ser Ile Asn Ser Ala Trp
    690                 695                 700                 
Ser Glu His Ser Leu Asp Pro Glu Asp Ile Arg Asp Glu Leu Lys Lys
705                 710                 715                 720 
Leu Tyr Ala Gln Leu Glu Ile Tyr Lys Arg Lys Lys Met Ile Thr Asn
                725                 730                 735     
Asn Pro His Leu Gln Lys Lys Arg Cys Ser Lys Lys Gly Leu Gly Arg
            740                 745                 750         
Ser Ile Met Arg Arg Ile Thr Glu Ile Pro Glu Thr Val Ser Arg Gln
        755                 760                 765             
Cys Ser Lys Glu Asp Lys Glu Gly Ala Asp His Gly Thr Ala Lys Gly
    770                 775                 780                 
Thr Ala Leu Ile Arg Lys Asn Pro Pro Glu Ser Ser Gly Asn Thr Gly
785                 790                 795                 800 
Lys Ser Lys Glu Glu Thr Leu Lys Asn Arg Val Phe Ser Leu Lys Lys
                805                 810                 815     
Ser His Ser Thr Tyr Asp His Val Arg Asp Gln Thr Glu Glu Ser Ser
            820                 825                 830         
Ser Leu Pro Thr Glu Ser Gln Glu Glu Glu Thr Thr Glu Asn Ser Thr
        835                 840                 845             
Leu Glu Ser Leu Ser Gly Lys Lys Leu Thr Gln Lys Leu Lys Glu Asp
    850                 855                 860                 
Ser Glu Ala Glu Ser Thr Glu Ser Val Pro Leu Val Cys Lys Ser Ala
865                 870                 875                 880 
Ser Ala His Asn Leu Ser Ser Glu Lys Lys Thr Gly His Pro Arg Thr
                885                 890                 895     
Ser Met Leu Gln Lys Ser Leu Ser Val Ile Ala Ser Ala Lys Glu Lys
            900                 905                 910         
Thr Leu Gly Leu Ala Gly Lys Thr Gln Thr Ala Gly Val Glu Glu Arg
        915                 920                 925             
Thr Lys Ser Gln Lys Pro Leu Pro Lys Asp Lys Glu Thr Asn Arg Asn
    930                 935                 940                 
His Ser Asn Ser Asp Asn Thr Glu Thr Lys Asp Pro Ala Pro Gln Asn
945                 950                 955                 960 
Ser Asn Pro Ala Glu Glu Pro Arg Lys Pro Gln Lys Ser Gly Ile Met
                965                 970                 975     
Lys Gln Gln Arg Val Asn Pro Thr Thr Ala Asn Ser Asp Leu Asn Pro
            980                 985                 990         
Gly Thr Thr Gln Met Lys Asp Asn Phe Asp Ile Gly Glu Val Cys Pro
        995                 1000                1005            
Trp Glu Val Tyr Asp Leu Thr Pro Gly Pro Val Pro Ser Glu Ser Lys
    1010                1015                1020                
Val Gln Lys His Val Ser Ile Val Ala Ser Glu Met Glu Lys Asn Pro
1025                1030                1035                1040
Thr Phe Ser Leu Lys Glu Lys Ser His His Lys Pro Lys Ala Ala Glu
                1045                1050                1055    
Val Cys Gln Gln Ser Asn Gln Lys Arg Ile Asp Lys Ala Glu Val Cys
            1060                1065                1070        
Leu Trp Glu Ser Gln Gly Gln Ser Ile Leu Glu Asp Glu Lys Leu Leu
        1075                1080                1085            
Ile Ser Lys Thr Pro Val Leu Pro Glu Arg Ala Lys Glu Glu Asn Gly
    1090                1095                1100                
Gly Gln Pro Arg Ala Ala Asn Val Cys Ala Gly Gln Ser Glu Glu Leu
1105                1110                1115                1120
Pro Pro Lys Ala Val Ala Ser Lys Thr Glu Asn Glu Asn Leu Asn Gln
                1125                1130                1135    
Ile Gly His Gln Glu Lys Lys Thr Ser Ser Ser Glu Glu Asn Val Arg
            1140                1145                1150        
Gly Ser Tyr Asn Ser Ser Asn Asn Phe Gln Gln Pro Leu Thr Ser Arg
        1155                1160                1165            
Ala Glu Val Cys Pro Trp Glu Phe Glu Thr Pro Ala Gln Pro Asn Ala
    1170                1175                1180                
Gly Arg Ser Val Ala Leu Pro Ala Ser Ser Ala Leu Ser Ala Asn Lys
1185                1190                1195                1200
Ile Ala Gly Pro Arg Lys Glu Glu Ile Trp Asp Ser Phe Lys Val
                1205                1210                1215


<210> 9149
<211> 816
<212> PRT
<213> Homo sapiens

<400> 9149
Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro
 1               5                  10                  15      
Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu
            20                  25                  30          
Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val
        35                  40                  45              
Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn
    50                  55                  60                  
Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser
65                  70                  75                  80  
Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser
                85                  90                  95      
Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln
            100                 105                 110         
His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe
        115                 120                 125             
Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu
    130                 135                 140                 
Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His
145                 150                 155                 160 
Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser
                165                 170                 175     
Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser
            180                 185                 190         
Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu
        195                 200                 205             
Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu
    210                 215                 220                 
Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala
225                 230                 235                 240 
Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly
                245                 250                 255     
Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu
            260                 265                 270         
Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala
        275                 280                 285             
Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val
    290                 295                 300                 
Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn
305                 310                 315                 320 
Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr
                325                 330                 335     
His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp
            340                 345                 350         
Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met
        355                 360                 365             
Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val
    370                 375                 380                 
Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser
385                 390                 395                 400 
Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu
                405                 410                 415     
Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn
            420                 425                 430         
Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln
        435                 440                 445             
Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly
    450                 455                 460                 
Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met
465                 470                 475                 480 
Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val
                485                 490                 495     
Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe
            500                 505                 510         
Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr
        515                 520                 525             
Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr
    530                 535                 540                 
Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser
545                 550                 555                 560 
Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro
                565                 570                 575     
Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu
            580                 585                 590         
Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser
        595                 600                 605             
Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly
    610                 615                 620                 
Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala
625                 630                 635                 640 
Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr
                645                 650                 655     
Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser
            660                 665                 670         
Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu
        675                 680                 685             
Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg
    690                 695                 700                 
His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp
705                 710                 715                 720 
Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln
                725                 730                 735     
Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu
            740                 745                 750         
Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro
        755                 760                 765             
Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn
    770                 775                 780                 
Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly
785                 790                 795                 800 
Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val
                805                 810                 815     


<210> 9150
<211> 617
<212> PRT
<213> Homo sapiens

<400> 9150
Met Leu Leu Ala Arg Met Asn Pro Gln Val Gln Pro Glu Asn Asn Gly
 1               5                  10                  15      
Ala Asp Thr Gly Pro Glu Gln Pro Leu Arg Ala Arg Lys Thr Ala Glu
            20                  25                  30          
Leu Leu Val Val Lys Glu Arg Asn Gly Val Gln Cys Leu Leu Ala Pro
        35                  40                  45              
Arg Asp Gly Asp Ala Gln Pro Arg Glu Thr Trp Gly Lys Lys Ile Asp
    50                  55                  60                  
Phe Leu Leu Ser Val Val Gly Phe Ala Val Asp Leu Ala Asn Val Trp
65                  70                  75                  80  
Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu Ile
                85                  90                  95      
Pro Tyr Thr Leu Phe Leu Ile Ile Ala Gly Met Pro Leu Phe Tyr Met
            100                 105                 110         
Glu Leu Ala Leu Gly Gln Tyr Asn Arg Glu Gly Ala Ala Thr Val Trp
        115                 120                 125             
Lys Ile Cys Pro Phe Phe Lys Gly Val Gly Tyr Ala Val Ile Leu Ile
    130                 135                 140                 
Ala Leu Tyr Val Gly Phe Tyr Tyr Asn Val Ile Ile Ala Trp Ser Leu
145                 150                 155                 160 
Tyr Tyr Leu Phe Ser Ser Phe Thr Leu Asn Leu Pro Trp Thr Asp Cys
                165                 170                 175     
Gly His Thr Trp Asn Ser Pro Asn Cys Thr Asp Pro Lys Leu Leu Asn
            180                 185                 190         
Gly Ser Val Leu Gly Asn His Thr Lys Tyr Ser Lys Tyr Lys Phe Thr
        195                 200                 205             
Pro Ala Ala Glu Phe Tyr Glu Arg Gly Val Leu His Leu His Glu Ser
    210                 215                 220                 
Ser Gly Ile His Asp Ile Gly Leu Pro Gln Trp Gln Leu Leu Leu Cys
225                 230                 235                 240 
Leu Met Val Val Val Ile Val Leu Tyr Phe Ser Leu Trp Lys Gly Val
                245                 250                 255     
Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Leu Pro Tyr Phe
            260                 265                 270         
Val Leu Phe Val Leu Leu Val His Gly Val Thr Leu Pro Gly Ala Ser
        275                 280                 285             
Asn Gly Ile Asn Ala Tyr Leu His Ile Asp Phe Tyr Arg Leu Lys Glu
    290                 295                 300                 
Ala Thr Val Trp Ile Asp Ala Ala Thr Gln Ile Phe Phe Ser Leu Gly
305                 310                 315                 320 
Ala Gly Phe Gly Val Leu Ile Ala Phe Ala Ser Tyr Asn Lys Phe Asp
                325                 330                 335     
Asn Asn Cys Tyr Arg Asp Ala Leu Leu Thr Ser Ser Ile Asn Cys Ile
            340                 345                 350         
Thr Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Tyr Met
        355                 360                 365             
Ala His Glu His Lys Val Asn Ile Glu Asp Val Ala Thr Glu Gly Ala
    370                 375                 380                 
Gly Leu Val Phe Ile Leu Tyr Pro Glu Ala Ile Ser Thr Leu Ser Gly
385                 390                 395                 400 
Ser Thr Phe Trp Ala Val Val Phe Phe Val Met Leu Leu Ala Leu Gly
                405                 410                 415     
Leu Asp Ser Ser Met Gly Gly Met Glu Ala Val Ile Thr Gly Leu Ala
            420                 425                 430         
Asp Asp Phe Gln Val Leu Lys Arg His Arg Lys Leu Phe Thr Phe Gly
        435                 440                 445             
Val Thr Phe Ser Thr Phe Leu Leu Ala Leu Phe Cys Ile Thr Lys Gly
    450                 455                 460                 
Gly Ile Tyr Val Leu Thr Leu Leu Asp Thr Phe Ala Ala Gly Thr Ser
465                 470                 475                 480 
Ile Leu Phe Ala Val Leu Met Glu Ala Ile Gly Val Ser Trp Phe Tyr
                485                 490                 495     
Gly Val Asp Arg Phe Ser Asn Asp Ile Gln Gln Met Met Gly Phe Arg
            500                 505                 510         
Pro Gly Leu Tyr Trp Arg Leu Cys Trp Lys Phe Val Ser Pro Ala Phe
        515                 520                 525             
Leu Leu Phe Val Val Val Val Ser Ile Ile Asn Phe Lys Pro Leu Thr
    530                 535                 540                 
Tyr Asp Asp Tyr Ile Phe Pro Pro Trp Ala Asn Trp Val Gly Trp Gly
545                 550                 555                 560 
Ile Ala Leu Ser Ser Met Val Leu Val Pro Ile Tyr Val Ile Tyr Lys
                565                 570                 575     
Phe Leu Ser Thr Gln Gly Ser Leu Trp Glu Arg Leu Ala Tyr Gly Ile
            580                 585                 590         
Thr Pro Glu Asn Glu His His Leu Val Ala Gln Arg Asp Ile Arg Gln
        595                 600                 605             
Phe Gln Leu Gln His Trp Leu Ala Ile
    610                 615         


<210> 9151
<211> 362
<212> PRT
<213> Homo sapiens

<400> 9151
Met Asp Leu His Leu Phe Asp Tyr Ala Glu Pro Gly Asn Phe Ser Asp
 1               5                  10                  15      
Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val
            20                  25                  30          
Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser
        35                  40                  45              
Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val
    50                  55                  60                  
Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His
65                  70                  75                  80  
Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr
                85                  90                  95      
Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met
            100                 105                 110         
Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu
        115                 120                 125             
Phe Ser Gly Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu
    130                 135                 140                 
Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val
145                 150                 155                 160 
Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser
                165                 170                 175     
Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn
            180                 185                 190         
Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp
        195                 200                 205             
Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro
    210                 215                 220                 
Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser
225                 230                 235                 240 
Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser
                245                 250                 255     
Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val
            260                 265                 270         
Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg
        275                 280                 285             
Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser
    290                 295                 300                 
Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg
305                 310                 315                 320 
Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala
                325                 330                 335     
Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr
            340                 345                 350         
Glu Tyr Ser Ala Leu Glu Gln Asn Ala Lys
        355                 360         


<210> 9152
<211> 362
<212> PRT
<213> Homo sapiens

<400> 9152
Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp
 1               5                  10                  15      
Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val
            20                  25                  30          
Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser
        35                  40                  45              
Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val
    50                  55                  60                  
Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His
65                  70                  75                  80  
Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr
                85                  90                  95      
Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met
            100                 105                 110         
Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu
        115                 120                 125             
Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu
    130                 135                 140                 
Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val
145                 150                 155                 160 
Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser
                165                 170                 175     
Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn
            180                 185                 190         
Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp
        195                 200                 205             
Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro
    210                 215                 220                 
Phe Ser Ile Val Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser
225                 230                 235                 240 
Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser
                245                 250                 255     
Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val
            260                 265                 270         
Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg
        275                 280                 285             
Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser
    290                 295                 300                 
Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg
305                 310                 315                 320 
Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala
                325                 330                 335     
Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr
            340                 345                 350         
Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys
        355                 360         


<210> 9153
<211> 208
<212> PRT
<213> Homo sapiens

<400> 9153
Met Gly Leu Gly Ala Arg Gly Ala Trp Ala Ala Leu Leu Leu Gly Thr
 1               5                  10                  15      
Leu Gln Val Leu Ala Leu Leu Gly Ala Ala His Glu Ser Ala Ala Met
            20                  25                  30          
Ala Ala Ser Ala Asn Ile Glu Asn Ser Gly Leu Pro His Asn Ser Ser
        35                  40                  45              
Ala Asn Ser Thr Glu Thr Leu Gln His Val Pro Ser Asp His Thr Asn
    50                  55                  60                  
Glu Thr Ser Asn Ser Thr Val Lys Pro Pro Thr Ser Val Ala Ser Asp
65                  70                  75                  80  
Ser Ser Asn Thr Thr Val Thr Thr Met Lys Pro Thr Ala Ala Ser Asn
                85                  90                  95      
Thr Thr Thr Pro Gly Met Val Ser Thr Asn Met Thr Ser Thr Thr Leu
            100                 105                 110         
Lys Ser Thr Pro Lys Thr Thr Ser Val Ser Gln Asn Thr Ser Gln Ile
        115                 120                 125             
Ser Thr Ser Thr Met Thr Val Thr His Asn Ser Ser Val Thr Ser Ala
    130                 135                 140                 
Ala Ser Ser Val Thr Ile Thr Thr Thr Met His Ser Glu Ala Lys Lys
145                 150                 155                 160 
Gly Ser Lys Phe Asp Thr Gly Ser Phe Val Gly Gly Ile Val Leu Thr
                165                 170                 175     
Leu Gly Val Leu Ser Ile Leu Tyr Ile Gly Cys Lys Met Tyr Tyr Ser
            180                 185                 190         
Arg Arg Gly Ile Arg Tyr Arg Thr Ile Asp Glu His Asp Ala Ile Ile
        195                 200                 205             


<210> 9154
<211> 262
<212> PRT
<213> Homo sapiens

<400> 9154
Pro Pro Ser Pro Ala Pro Pro Pro Arg Leu Arg Thr Arg Arg Pro Leu
 1               5                  10                  15      
Gln Ala Pro Leu Leu Arg Pro Ile Trp Ser Phe Gly Gly Gln Ala Ala
            20                  25                  30          
Gly Gly Glu Thr Cys Ala Ala Glu Gly Glu Ala Glu Pro Ala Pro Ala
        35                  40                  45              
Ala Gln Arg Ser Arg Ser Arg Arg Arg His Leu Gly Trp Glu Pro Thr
    50                  55                  60                  
Arg Leu Pro His Pro Ala Leu Gly Thr Met Gly Leu Gly Ala Arg Gly
65                  70                  75                  80  
Ala Trp Ala Ala Leu Leu Leu Gly Thr Leu Gln Val Leu Ala Leu Leu
                85                  90                  95      
Gly Ala Ala His Glu Ser Ala Ala Met Ala Glu Thr Leu Gln His Val
            100                 105                 110         
Pro Ser Asp His Thr Asn Glu Thr Ser Asn Ser Thr Val Lys Pro Pro
        115                 120                 125             
Thr Ser Val Ala Ser Asp Ser Ser Asn Thr Thr Val Thr Thr Met Lys
    130                 135                 140                 
Pro Thr Ala Ala Ser Asn Thr Thr Thr Pro Gly Met Val Ser Thr Asn
145                 150                 155                 160 
Met Thr Ser Thr Thr Leu Lys Ser Thr Pro Lys Thr Thr Ser Val Ser
                165                 170                 175     
Gln Asn Thr Ser Gln Ile Ser Thr Ser Thr Met Thr Val Thr His Asn
            180                 185                 190         
Ser Ser Val Thr Ser Ala Ala Ser Ser Val Thr Ile Thr Thr Thr Met
        195                 200                 205             
His Ser Glu Ala Lys Lys Gly Ser Lys Phe Asp Thr Gly Ser Phe Val
    210                 215                 220                 
Gly Gly Ile Val Leu Thr Leu Gly Val Leu Ser Ile Leu Tyr Ile Gly
225                 230                 235                 240 
Cys Lys Met Tyr Tyr Ser Arg Arg Gly Ile Arg Tyr Arg Thr Ile Asp
                245                 250                 255     
Glu His Asp Ala Ile Ile
            260         


<210> 9155
<211> 208
<212> PRT
<213> Homo sapiens

<400> 9155
Met Gly Leu Gly Ala Arg Gly Ala Trp Ala Ala Leu Leu Leu Gly Thr
 1               5                  10                  15      
Leu Gln Ala Leu Ala Leu Leu Gly Ala Ala His Glu Ser Ala Ala Met
            20                  25                  30          
Ala Ala Ser Ala Asn Ile Glu Asn Ser Gly Leu Pro His Asn Ser Ser
        35                  40                  45              
Ala Asn Ser Thr Glu Thr Leu Gln His Val Pro Ser Asp His Thr Asn
    50                  55                  60                  
Glu Thr Ser Asn Ser Thr Val Lys Pro Pro Thr Ser Val Ala Ser Asp
65                  70                  75                  80  
Ser Ser Asn Thr Thr Val Thr Thr Met Lys Pro Thr Ala Ala Ser Asn
                85                  90                  95      
Thr Thr Thr Pro Gly Met Val Ser Thr Asn Met Thr Ser Thr Thr Leu
            100                 105                 110         
Lys Ser Thr Pro Lys Thr Thr Ser Val Ser Gln Asn Thr Ser Gln Ile
        115                 120                 125             
Ser Thr Ser Thr Met Thr Val Thr His Asn Ser Ser Val Thr Ser Ala
    130                 135                 140                 
Ala Ser Ser Val Thr Ile Thr Thr Thr Met His Ser Glu Ala Lys Lys
145                 150                 155                 160 
Gly Ser Lys Phe Asp Thr Gly Ser Phe Val Gly Gly Ile Val Leu Thr
                165                 170                 175     
Leu Gly Val Leu Ser Ile Leu Tyr Ile Gly Cys Lys Met Tyr Tyr Ser
            180                 185                 190         
Arg Arg Gly Ile Arg Tyr Arg Thr Ile Asp Glu His Asp Ala Ile Ile
        195                 200                 205             


<210> 9156
<211> 2799
<212> PRT
<213> Homo sapiens

<400> 9156
Met Asp Asp Asn Ser Arg Tyr Trp Met Ala Phe Ser Tyr Ile Thr Asn
 1               5                  10                  15      
Asn Ala Leu Leu Gly Arg Glu Asp Ile Asp Leu Gly Leu Ala Gly Asp
            20                  25                  30          
His Gln Gln Leu Ile Leu Tyr Arg Leu Gly Lys Thr Phe Ser Ile Arg
        35                  40                  45              
His His Leu Ala Ser Phe Gln Trp His Thr Ile Cys Leu Ile Trp Asp
    50                  55                  60                  
Gly Val Lys Gly Lys Leu Glu Leu Phe Leu Asn Lys Glu Arg Ile Leu
65                  70                  75                  80  
Glu Val Thr Asp Gln Pro His Asn Leu Thr Pro His Gly Thr Leu Phe
                85                  90                  95      
Leu Gly His Phe Leu Lys Asn Glu Ser Ser Glu Val Lys Ser Met Met
            100                 105                 110         
Arg Ser Phe Pro Gly Ser Leu Tyr Tyr Phe Gln Leu Trp Asp His Ile
        115                 120                 125             
Leu Glu Asn Glu Glu Phe Met Lys Cys Leu Asp Gly Asn Ile Val Ser
    130                 135                 140                 
Trp Glu Glu Asp Val Trp Leu Val Asn Lys Ile Ile Pro Thr Val Asp
145                 150                 155                 160 
Arg Thr Leu Arg Cys Val Pro Glu Asn Met Thr Ile Gln Glu Lys Ser
                165                 170                 175     
Thr Thr Val Ser Gln Gln Ile Asp Met Thr Thr Pro Ser Gln Ile Thr
            180                 185                 190         
Gly Val Lys Pro Gln Asn Thr Ala His Ser Ser Thr Leu Leu Ser Gln
        195                 200                 205             
Ser Ile Pro Ile Phe Ala Thr Asp Tyr Thr Thr Ile Ser Tyr Ser Asn
    210                 215                 220                 
Thr Thr Ser Pro Pro Leu Glu Thr Met Thr Ala Gln Lys Ile Leu Lys
225                 230                 235                 240 
Thr Leu Val Asp Glu Thr Ala Thr Phe Ala Val Asp Val Leu Ser Thr
                245                 250                 255     
Ser Ser Ala Ile Ser Leu Pro Thr Gln Ser Ile Ser Ile Asp Asn Thr
            260                 265                 270         
Thr Asn Ser Met Lys Lys Thr Lys Ser Pro Ser Ser Glu Ser Thr Lys
        275                 280                 285             
Thr Thr Lys Met Val Glu Ala Met Ala Thr Glu Ile Phe Gln Pro Pro
    290                 295                 300                 
Thr Pro Ser Asn Phe Leu Ser Thr Ser Arg Phe Thr Lys Asn Ser Val
305                 310                 315                 320 
Val Ser Thr Thr Ser Ala Ile Lys Ser Gln Ser Ala Val Thr Lys Thr
                325                 330                 335     
Thr Ser Leu Phe Ser Thr Ile Glu Ser Thr Ser Met Ser Thr Thr Pro
            340                 345                 350         
Cys Leu Lys Gln Lys Ser Thr Asn Thr Gly Ala Leu Pro Ile Ser Thr
        355                 360                 365             
Ala Gly Gln Glu Phe Ile Glu Ser Thr Ala Ala Gly Thr Val Pro Trp
    370                 375                 380                 
Phe Thr Val Glu Lys Thr Ser Pro Ala Ser Thr His Val Gly Thr Ala
385                 390                 395                 400 
Ser Ser Phe Pro Pro Glu Pro Val Leu Ile Ser Thr Ala Ala Pro Val
                405                 410                 415     
Asp Ser Val Phe Pro Arg Asn Gln Thr Ala Phe Pro Leu Ala Thr Thr
            420                 425                 430         
Asp Met Lys Ile Ala Phe Thr Val His Ser Leu Thr Leu Pro Thr Arg
        435                 440                 445             
Leu Ile Glu Thr Thr Pro Ala Pro Arg Thr Ala Glu Thr Glu Leu Thr
    450                 455                 460                 
Ser Thr Asn Phe Gln Asp Val Ser Leu Pro Arg Val Glu Asp Ala Met
465                 470                 475                 480 
Ser Thr Ser Met Ser Lys Glu Thr Ser Ser Lys Thr Phe Ser Phe Leu
                485                 490                 495     
Thr Ser Phe Ser Phe Thr Gly Thr Glu Ser Val Gln Thr Val Ile Asp
            500                 505                 510         
Ala Glu Ala Thr Arg Thr Ala Leu Thr Pro Glu Ile Thr Leu Ala Ser
        515                 520                 525             
Thr Val Ala Glu Thr Met Leu Ser Ser Thr Ile Thr Gly Arg Val Tyr
    530                 535                 540                 
Thr Gln Asn Thr Pro Thr Ala Asp Gly His Leu Leu Thr Leu Met Ser
545                 550                 555                 560 
Thr Arg Ser Ala Ser Thr Ser Lys Ala Pro Glu Ser Gly Pro Thr Ser
                565                 570                 575     
Thr Thr Asp Glu Ala Ala His Leu Phe Ser Ser Asn Glu Thr Ile Trp
            580                 585                 590         
Thr Ser Arg Pro Asp Gln Ala Leu Leu Ala Ser Met Asn Thr Thr Thr
        595                 600                 605             
Ile Leu Thr Phe Val Pro Asn Glu Asn Phe Thr Ser Ala Phe His Glu
    610                 615                 620                 
Asn Thr Thr Tyr Thr Glu Tyr Leu Ser Ala Thr Thr Asn Ile Thr Pro
625                 630                 635                 640 
Leu Lys Ala Ser Pro Glu Gly Lys Gly Thr Thr Ala Asn Asp Ala Thr
                645                 650                 655     
Thr Ala Arg Tyr Thr Thr Ala Val Ser Lys Leu Thr Ser Pro Trp Phe
            660                 665                 670         
Ala Asn Phe Ser Ile Val Ser Gly Thr Thr Ser Ile Thr Asn Met Pro
        675                 680                 685             
Glu Phe Lys Leu Thr Thr Leu Leu Leu Lys Thr Ile Pro Met Ser Thr
    690                 695                 700                 
Lys Pro Ala Asn Glu Leu Pro Leu Thr Pro Arg Glu Thr Val Val Pro
705                 710                 715                 720 
Ser Val Asp Ile Ile Ser Thr Leu Ala Cys Ile Gln Pro Asn Phe Ser
                725                 730                 735     
Thr Glu Glu Ser Ala Ser Glu Thr Thr Gln Thr Glu Ile Asn Gly Ala
            740                 745                 750         
Ile Val Phe Gly Gly Thr Thr Thr Pro Val Pro Lys Ser Ala Thr Thr
        755                 760                 765             
Gln Arg Leu Asn Ala Thr Val Thr Arg Lys Glu Ala Thr Ser His Tyr
    770                 775                 780                 
Leu Met Arg Lys Ser Thr Ile Ala Ala Val Ala Glu Val Ser Pro Phe
785                 790                 795                 800 
Ser Thr Met Leu Glu Val Thr Asp Glu Ser Ala Gln Arg Val Thr Ala
                805                 810                 815     
Ser Val Thr Val Ser Ser Phe Pro Asp Ile Glu Lys Leu Ser Thr Pro
            820                 825                 830         
Leu Asp Asn Lys Thr Ala Thr Thr Glu Val Arg Glu Ser Trp Leu Leu
        835                 840                 845             
Thr Lys Leu Val Lys Thr Thr Pro Arg Ser Ser Tyr Asn Glu Met Thr
    850                 855                 860                 
Glu Met Phe Asn Phe Asn His Thr Tyr Val Ala His Trp Thr Ser Glu
865                 870                 875                 880 
Thr Ser Glu Gly Ile Ser Ala Gly Ser Pro Thr Ser Gly Ser Thr His
                885                 890                 895     
Ile Phe Gly Glu Pro Leu Gly Ala Ser Thr Thr Arg Ile Ser Glu Thr
            900                 905                 910         
Ser Phe Ser Thr Thr Pro Thr Asp Arg Thr Ala Thr Ser Leu Ser Asp
        915                 920                 925             
Gly Ile Leu Pro Pro Gln Pro Thr Ala Ala His Ser Ser Ala Thr Pro
    930                 935                 940                 
Val Pro Val Thr His Met Phe Ser Leu Pro Val Asn Gly Ser Ser Val
945                 950                 955                 960 
Val Ala Glu Glu Thr Glu Val Thr Met Ser Glu Pro Ser Thr Leu Ala
                965                 970                 975     
Arg Ala Phe Ser Thr Ser Val Leu Ser Asp Val Ser Asn Leu Ser Ser
            980                 985                 990         
Thr Thr Met Thr Thr Ala Leu Val Pro Pro Leu Asp Gln Thr Ala Ser
        995                 1000                1005            
Thr Thr Ile Val Ile Val Pro Thr His Gly Asp Leu Ile Arg Thr Thr
    1010                1015                1020                
Ser Glu Ala Thr Val Ile Ser Val Arg Lys Thr Ser Met Ala Val Pro
1025                1030                1035                1040
Ser Leu Thr Glu Thr Pro Phe His Ser Leu Arg Leu Ser Thr Pro Val
                1045                1050                1055    
Thr Ala Lys Ala Glu Thr Thr Leu Phe Ser Thr Ser Val Asp Thr Val
            1060                1065                1070        
Thr Pro Ser Thr His Thr Leu Val Cys Ser Lys Pro Pro Pro Asp Asn
        1075                1080                1085            
Ile Pro Pro Ala Ser Ser Thr His Val Ile Ser Thr Thr Ser Thr Pro
    1090                1095                1100                
Glu Ala Thr Gln Pro Ile Ser Gln Val Glu Glu Thr Ser Thr Tyr Ala
1105                1110                1115                1120
Leu Ser Phe Pro Tyr Thr Phe Ser Gly Gly Gly Val Val Ala Ser Leu
                1125                1130                1135    
Ala Thr Gly Thr Thr Glu Thr Ser Val Val Asp Glu Thr Thr Pro Ser
            1140                1145                1150        
His Ile Ser Ala Asn Lys Leu Thr Thr Ser Val Asn Ser His Ile Ser
        1155                1160                1165            
Ser Ser Ala Thr Tyr Arg Val His Thr Pro Val Ser Ile Gln Leu Val
    1170                1175                1180                
Thr Ser Thr Ser Val Leu Ser Ser Asp Lys Asp Gln Met Thr Ile Ser
1185                1190                1195                1200
Leu Gly Lys Thr Pro Arg Thr Met Glu Val Thr Glu Met Ser Pro Ser
                1205                1210                1215    
Lys Asn Ser Phe Ile Ser Tyr Ser Arg Gly Thr Pro Ser Leu Glu Met
            1220                1225                1230        
Thr Asp Thr Gly Phe Pro Glu Thr Thr Lys Ile Ser Ser His Gln Thr
        1235                1240                1245            
His Ser Pro Ser Glu Ile Pro Leu Gly Thr Pro Ser Asp Gly Asn Leu
    1250                1255                1260                
Ala Ser Ser Pro Thr Ser Gly Ser Thr Gln Ile Thr Pro Thr Leu Thr
1265                1270                1275                1280
Ser Ser Asn Thr Val Gly Val His Ile Pro Glu Met Ser Thr Ser Leu
                1285                1290                1295    
Gly Lys Thr Ala Leu Pro Ser Gln Ala Leu Thr Ile Thr Thr Phe Leu
            1300                1305                1310        
Cys Pro Glu Lys Glu Ser Thr Ser Ala Leu Pro Ala Tyr Thr Pro Arg
        1315                1320                1325            
Thr Val Glu Met Ile Val Asn Ser Thr Tyr Val Thr His Ser Val Ser
    1330                1335                1340                
Tyr Gly Gln Asp Thr Ser Phe Val Asp Thr Thr Thr Ser Ser Ser Thr
1345                1350                1355                1360
Arg Ile Ser Asn Pro Met Asp Ile Asn Thr Thr Phe Ser His Leu His
                1365                1370                1375    
Ser Leu Arg Thr Gln Pro Glu Val Thr Ser Val Ala Ser Phe Ile Ser
            1380                1385                1390        
Glu Ser Thr Gln Thr Phe Pro Glu Ser Leu Ser Leu Ser Thr Ala Gly
        1395                1400                1405            
Leu Tyr Asn Asp Gly Phe Thr Val Leu Ser Asp Arg Ile Thr Thr Ala
    1410                1415                1420                
Phe Ser Val Pro Asn Val Pro Thr Met Leu Pro Arg Glu Ser Ser Met
1425                1430                1435                1440
Ala Thr Ser Thr Pro Ile Tyr Gln Met Ser Ser Leu Pro Val Asn Val
                1445                1450                1455    
Thr Ala Phe Thr Ser Lys Lys Val Ser Asp Thr Pro Pro Ile Val Ile
            1460                1465                1470        
Thr Lys Ser Ser Lys Thr Met His Pro Gly Cys Leu Lys Ser Pro Cys
        1475                1480                1485            
Thr Ala Thr Ser Gly Pro Met Ser Glu Met Ser Ser Ile Pro Val Asn
    1490                1495                1500                
Asn Ser Ala Phe Thr Pro Ala Thr Val Ser Ser Asp Thr Ser Thr Arg
1505                1510                1515                1520
Val Gly Leu Phe Ser Thr Leu Leu Ser Ser Val Thr Pro Arg Thr Thr
                1525                1530                1535    
Met Thr Met Gln Thr Ser Thr Leu Asp Val Thr Pro Val Ile Tyr Ala
            1540                1545                1550        
Gly Ala Thr Ser Lys Asn Lys Met Val Ser Ser Ala Phe Thr Thr Glu
        1555                1560                1565            
Met Ile Glu Ala Pro Ser Arg Ile Thr Pro Thr Thr Phe Leu Ser Pro
    1570                1575                1580                
Thr Glu Pro Thr Leu Pro Phe Val Lys Thr Val Pro Thr Thr Ile Met
1585                1590                1595                1600
Ala Gly Ile Val Thr Pro Phe Val Gly Thr Thr Ala Phe Ser Pro Leu
                1605                1610                1615    
Ser Ser Lys Ser Thr Gly Ala Ile Ser Ser Ile Pro Lys Thr Thr Phe
            1620                1625                1630        
Ser Pro Phe Leu Ser Ala Thr Gln Gln Ser Ser Gln Ala Asp Glu Ala
        1635                1640                1645            
Thr Thr Leu Gly Ile Leu Ser Gly Ile Thr Asn Arg Ser Leu Ser Thr
    1650                1655                1660                
Val Asn Ser Gly Thr Gly Val Ala Leu Thr Asp Thr Tyr Ser Arg Ile
1665                1670                1675                1680
Thr Val Pro Glu Asn Met Leu Ser Pro Thr His Ala Asp Ser Leu His
                1685                1690                1695    
Thr Ser Phe Asn Ile Gln Val Ser Pro Ser Leu Thr Ser Phe Lys Ser
            1700                1705                1710        
Ala Ser Gly Pro Thr Lys Asn Val Lys Thr Thr Thr Asn Cys Phe Ser
        1715                1720                1725            
Ser Asn Thr Arg Lys Met Thr Ser Leu Leu Glu Lys Thr Ser Leu Thr
    1730                1735                1740                
Asn Tyr Ala Thr Ser Leu Asn Thr Pro Val Ser Tyr Pro Pro Trp Thr
1745                1750                1755                1760
Pro Ser Ser Ala Thr Leu Pro Ser Leu Thr Ser Phe Val Tyr Ser Pro
                1765                1770                1775    
His Ser Thr Glu Ala Glu Ile Ser Thr Pro Lys Thr Ser Pro Pro Pro
            1780                1785                1790        
Thr Ser Gln Met Val Glu Phe Pro Val Leu Gly Thr Arg Met Thr Ser
        1795                1800                1805            
Ser Asn Thr Gln Pro Leu Leu Met Thr Ser Trp Asn Ile Pro Thr Ala
    1810                1815                1820                
Glu Gly Ser Gln Phe Pro Ile Ser Thr Thr Ile Asn Val Pro Thr Ser
1825                1830                1835                1840
Asn Glu Met Glu Thr Glu Thr Leu His Leu Val Pro Gly Pro Leu Ser
                1845                1850                1855    
Thr Phe Thr Ala Ser Gln Thr Gly Leu Val Ser Lys Asp Val Met Ala
            1860                1865                1870        
Met Ser Ser Ile Pro Met Ser Gly Ile Leu Pro Asn His Gly Leu Ser
        1875                1880                1885            
Glu Asn Pro Ser Leu Ser Thr Ser Leu Arg Ala Ile Thr Ser Thr Leu
    1890                1895                1900                
Ala Asp Val Lys His Thr Phe Glu Lys Met Thr Thr Ser Val Thr Pro
1905                1910                1915                1920
Gly Thr Thr Leu Pro Ser Ile Leu Ser Gly Ala Thr Ser Gly Ser Val
                1925                1930                1935    
Ile Ser Lys Ser Pro Ile Leu Thr Trp Leu Leu Ser Ser Leu Pro Ser
            1940                1945                1950        
Gly Ser Pro Pro Ala Thr Val Ser Asn Ala Pro His Val Met Thr Ser
        1955                1960                1965            
Ser Thr Val Glu Val Ser Lys Ser Thr Phe Leu Thr Ser Asp Met Ile
    1970                1975                1980                
Ser Ala His Pro Phe Thr Asn Leu Thr Thr Leu Pro Ser Ala Thr Met
1985                1990                1995                2000
Ser Thr Ile Leu Thr Arg Thr Ile Pro Thr Pro Thr Leu Gly Gly Ile
                2005                2010                2015    
Thr Thr Gly Phe Pro Thr Ser Leu Pro Met Ser Ile Asn Val Thr Asp
            2020                2025                2030        
Asp Ile Val Tyr Ile Ser Thr His Pro Glu Ala Ser Ser Arg Thr Thr
        2035                2040                2045            
Ile Thr Ala Asn Pro Arg Thr Val Ser His Pro Ser Ser Phe Ser Arg
    2050                2055                2060                
Lys Thr Met Ser Pro Ser Thr Thr Asp His Thr Leu Ser Val Gly Ala
2065                2070                2075                2080
Met Pro Leu Pro Ser Ser Thr Ile Thr Ser Ser Trp Asn Arg Ile Pro
                2085                2090                2095    
Thr Ala Ser Ser Pro Ser Thr Leu Ile Ile Pro Lys Pro Thr Leu Asp
            2100                2105                2110        
Ser Leu Leu Asn Ile Met Thr Thr Thr Ser Thr Val Pro Gly Ala Ser
        2115                2120                2125            
Phe Pro Leu Ile Ser Thr Gly Val Thr Tyr Pro Phe Thr Ala Thr Val
    2130                2135                2140                
Ser Ser Pro Ile Ser Ser Phe Phe Glu Thr Thr Trp Leu Asp Ser Thr
2145                2150                2155                2160
Pro Ser Phe Leu Ser Thr Glu Ala Ser Thr Ser Pro Thr Ala Thr Lys
                2165                2170                2175    
Ser Thr Glu Pro Gly Asn Cys Lys Ala Asp Glu Thr Ala Ser Lys Tyr
            2180                2185                2190        
Lys Gly Thr Tyr Lys Trp Leu Leu Thr Asn Pro Thr Glu Thr Ala Gln
        2195                2200                2205            
Thr Arg Cys Ile Lys Asn Glu Asp Gly Asn Ala Thr Arg Phe Ser Ile
    2210                2215                2220                
Ser Ile Asn Thr Gly Lys Ser Gln Trp Glu Lys Pro Lys Phe Lys Gln
2225                2230                2235                2240
Cys Lys Leu Leu Gln Glu Leu Pro Asp Lys Ile Val Asp Leu Ala Asn
                2245                2250                2255    
Ile Thr Ile Ser Asp Glu Asn Ala Glu Asp Val Ala Glu His Ile Leu
            2260                2265                2270        
Asn Leu Ile Asn Glu Ser Pro Ala Leu Gly Lys Glu Glu Thr Lys Ile
        2275                2280                2285            
Ile Val Ser Lys Ile Ser Asp Ile Ser Gln Cys Asp Glu Ile Ser Met
    2290                2295                2300                
Asn Leu Thr His Val Met Leu Gln Ile Ile Asn Val Val Leu Glu Lys
2305                2310                2315                2320
Gln Asn Asn Ser Ala Ser Asp Leu His Glu Ile Ser Asn Glu Ile Leu
                2325                2330                2335    
Arg Ile Ile Glu Arg Thr Gly His Lys Met Glu Phe Ser Gly Gln Ile
            2340                2345                2350        
Ala Asn Leu Thr Val Ala Gly Leu Ala Leu Ala Val Leu Arg Gly Asp
        2355                2360                2365            
His Thr Phe Asp Gly Met Ala Phe Ser Ile His Ser Tyr Glu Glu Gly
    2370                2375                2380                
Thr Asp Pro Glu Thr Lys Asn Val Thr Lys Ala Leu Thr Thr Tyr Val
2385                2390                2395                2400
Val Ser Ala Ser Ile Ser Asp Asp Met Phe Ile Gln Asn Leu Ala Asp
                2405                2410                2415    
Pro Val Val Ile Thr Leu Gln His Ile Gly Gly Asn Gln Asn Tyr Gly
            2420                2425                2430        
Gln Val His Cys Ala Phe Trp Asp Phe Glu Asn Asn Gly Leu Gly Gly
        2435                2440                2445            
Trp Asn Ser Ser Gly Cys Lys Val Lys Glu Thr Asn Val Asn Tyr Thr
    2450                2455                2460                
Ile Cys Gln Cys Asp His Leu Thr His Phe Gly Val Leu Met Asp Leu
2465                2470                2475                2480
Ser Arg Ser Thr Val Asp Ser Val Asn Glu Gln Ile Leu Ala Leu Ile
                2485                2490                2495    
Thr Tyr Thr Gly Cys Gly Ile Ser Ser Ile Phe Leu Gly Val Ala Val
            2500                2505                2510        
Val Thr Tyr Ile Ala Phe Lys Leu Arg Lys Asp Tyr Pro Ala Lys Ile
        2515                2520                2525            
Leu Ile Asn Leu Cys Thr Ala Leu Leu Met Leu Asn Leu Val Phe Leu
    2530                2535                2540                
Ile Asn Ser Trp Leu Ser Ser Phe Gln Lys Val Gly Val Cys Ile Thr
2545                2550                2555                2560
Ala Ala Val Ala Leu His Tyr Phe Leu Leu Val Ser Phe Thr Trp Met
                2565                2570                2575    
Gly Leu Glu Ala Val His Met Tyr Leu Ala Leu Val Lys Val Phe Asn
            2580                2585                2590        
Ile Tyr Ile Pro Asn Tyr Ile Leu Lys Phe Cys Leu Val Gly Trp Gly
        2595                2600                2605            
Ile Pro Ala Ile Met Val Ala Ile Thr Val Ser Val Lys Lys Asp Leu
    2610                2615                2620                
Tyr Gly Thr Leu Ser Pro Thr Thr Pro Cys Trp Ile Lys Asp Asp Ser
2625                2630                2635                2640
Ile Phe Tyr Ile Ser Val Val Ala Tyr Phe Cys Leu Ile Phe Leu Met
                2645                2650                2655    
Asn Leu Ser Met Phe Cys Thr Val Leu Val Gln Leu Asn Ser Val Lys
            2660                2665                2670        
Ser Gln Ile Gln Lys Thr Arg Arg Lys Met Ile Leu His Asp Leu Lys
        2675                2680                2685            
Gly Thr Met Ser Leu Thr Phe Leu Leu Gly Leu Thr Trp Gly Phe Ala
    2690                2695                2700                
Phe Phe Ala Trp Gly Pro Met Arg Asn Phe Phe Leu Tyr Leu Phe Ala
2705                2710                2715                2720
Ile Phe Asn Thr Leu Gln Asp Gly Ser Ser Arg Cys Gln Ile Lys Val
                2725                2730                2735    
Gly Tyr Lys Gln Glu Gly Leu Lys Lys Ile Phe Glu His Lys Leu Leu
            2740                2745                2750        
Thr Pro Ser Leu Lys Ser Thr Ala Thr Ser Ser Thr Phe Lys Ser Leu
        2755                2760                2765            
Gly Ser Ala Gln Gly Thr Pro Ser Glu Ile Ser Phe Pro Asn Ala Pro
    2770                2775                2780                
Glu Leu Ser Ala Leu His Val Val Ala Ser Glu Pro Thr Thr Gly
2785                2790                2795                


<210> 9157
<211> 902
<212> PRT
<213> Homo sapiens

<400> 9157
Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp
 1               5                  10                  15      
Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu
            20                  25                  30          
Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile
        35                  40                  45              
Phe Leu His Asn Thr Ala Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu
    50                  55                  60                  
Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr
65                  70                  75                  80  
Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly
                85                  90                  95      
Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala
            100                 105                 110         
Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser
        115                 120                 125             
Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser
    130                 135                 140                 
Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr
145                 150                 155                 160 
Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln
                165                 170                 175     
Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val
            180                 185                 190         
Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys
        195                 200                 205             
Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln
    210                 215                 220                 
Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala
225                 230                 235                 240 
Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly
                245                 250                 255     
Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val
            260                 265                 270         
Thr Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro
        275                 280                 285             
Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly
    290                 295                 300                 
Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile
305                 310                 315                 320 
Asp Ile Ser Arg Arg Gly Lys Ser Gly Asp Cys Leu Ala Asn Pro Ala
                325                 330                 335     
Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val
            340                 345                 350         
Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg
        355                 360                 365             
Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro
    370                 375                 380                 
Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln
385                 390                 395                 400 
Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr
                405                 410                 415     
Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys
            420                 425                 430         
Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val
        435                 440                 445             
Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile
    450                 455                 460                 
Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys
465                 470                 475                 480 
Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile
                485                 490                 495     
Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp
            500                 505                 510         
Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys
        515                 520                 525             
Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala
    530                 535                 540                 
Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val
545                 550                 555                 560 
Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu
                565                 570                 575     
Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu
            580                 585                 590         
Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln
        595                 600                 605             
Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly
    610                 615                 620                 
Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala
625                 630                 635                 640 
Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu
                645                 650                 655     
Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu
            660                 665                 670         
Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val
        675                 680                 685             
Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe
    690                 695                 700                 
Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly
705                 710                 715                 720 
Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Asp Asn Ile Glu Gln
                725                 730                 735     
Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys
            740                 745                 750         
Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val
        755                 760                 765             
Asn Leu Ala Val Leu Lys Leu Ser Glu Ala Gly Val Leu Asp Lys Leu
    770                 775                 780                 
Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Pro Lys Asp Ser
785                 790                 795                 800 
Gly Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly
                805                 810                 815     
Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala
            820                 825                 830         
Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys
        835                 840                 845             
Leu Thr Phe Ser Glu Ala Ile Arg Asn Lys Ala Arg Leu Ser Ile Thr
    850                 855                 860                 
Gly Ser Val Gly Glu Asn Gly Arg Val Leu Thr Pro Asp Cys Pro Lys
865                 870                 875                 880 
Ala Val His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val
                885                 890                 895     
Ile Ala Ser Asp Leu Pro
            900         


<210> 9158
<211> 614
<212> PRT
<213> Homo sapiens

<400> 9158
Met Val Gly Asn Leu Phe Val Ile Val Phe Val Ser Tyr Phe Gly Ser
 1               5                  10                  15      
Lys Leu His Arg Pro Lys Leu Ile Gly Ile Gly Cys Phe Leu Met Gly
            20                  25                  30          
Thr Gly Ser Ile Leu Met Ala Leu Pro His Phe Phe Met Gly Tyr Tyr
        35                  40                  45              
Arg Tyr Ser Lys Glu Thr Asn Ile Asp Pro Ser Glu Asn Ser Thr Ser
    50                  55                  60                  
Asn Leu Pro Asn Cys Leu Ile Asn Gln Met Leu Ser Leu Asn Arg Thr
65                  70                  75                  80  
Pro Ser Glu Ile Ile Glu Arg Gly Cys Val Lys Glu Ser Gly Ser His
                85                  90                  95      
Met Trp Ile Tyr Val Phe Met Gly Asn Met Leu Arg Gly Ile Gly Glu
            100                 105                 110         
Thr Pro Ile Val Pro Leu Gly Ile Ser Tyr Ile Asp Asp Phe Ala Lys
        115                 120                 125             
Glu Gly His Ser Ser Leu Tyr Leu Gly Thr Val Asn Val Met Gly Met
    130                 135                 140                 
Thr Gly Leu Val Phe Ala Phe Met Leu Gly Ser Leu Phe Ala Lys Met
145                 150                 155                 160 
Tyr Val Asp Ile Gly Tyr Val Asp Leu Ser Thr Ile Arg Ile Thr Pro
                165                 170                 175     
Lys Asp Ser Arg Trp Val Gly Ala Trp Trp Leu Gly Phe Leu Val Ser
            180                 185                 190         
Gly Ile Val Ser Ile Ile Ser Ser Ile Pro Phe Phe Phe Leu Pro Leu
        195                 200                 205             
Asn Pro Asn Lys Pro Gln Lys Glu Arg Lys Val Ser Leu Phe Leu His
    210                 215                 220                 
Val Leu Lys Thr Asn Asp Lys Arg Asn Gln Ile Ala Asn Leu Thr Asn
225                 230                 235                 240 
Arg Arg Lys Tyr Ile Thr Lys Asn Val Thr Gly Phe Phe Gln Ser Leu
                245                 250                 255     
Lys Ser Ile Leu Thr Asn Pro Leu Tyr Val Ile Phe Val Ile Phe Thr
            260                 265                 270         
Leu Leu His Met Ser Ser Tyr Ile Ala Ser Leu Thr Tyr Ile Ile Lys
        275                 280                 285             
Met Val Glu Gln Gln Tyr Gly Trp Ser Ala Ser Lys Thr Asn Phe Leu
    290                 295                 300                 
Leu Gly Val Leu Ala Leu Pro Ala Val Ala Ile Gly Met Phe Ser Gly
305                 310                 315                 320 
Gly Tyr Ile Ile Lys Lys Phe Lys Leu Ser Leu Val Gly Leu Ala Lys
                325                 330                 335     
Leu Ala Phe Cys Ser Ala Thr Val His Leu Leu Ser Gln Val Leu Tyr
            340                 345                 350         
Phe Phe Leu Ile Cys Glu Ser Lys Ser Val Ala Gly Leu Thr Leu Thr
        355                 360                 365             
Tyr Asp Gly Asn Ser Pro Val Arg Ser His Val Asp Val Pro Leu Ser
    370                 375                 380                 
Tyr Cys Asn Ser Glu Cys Asn Cys Asp Glu Ser Gln Trp Glu Pro Val
385                 390                 395                 400 
Cys Gly Asn Asn Gly Ile Thr Tyr Leu Ser Pro Cys Leu Ala Gly Cys
                405                 410                 415     
Lys Ser Ser Ser Gly Asn Lys Glu Pro Ile Val Phe Tyr Asn Cys Ser
            420                 425                 430         
Cys Val Glu Val Ile Gly Leu Gln Asn Lys Asn Tyr Ser Ala His Leu
        435                 440                 445             
Gly Glu Cys Pro Arg Asp Asp Ala Cys Thr Arg Lys Ser Tyr Val Tyr
    450                 455                 460                 
Phe Val Ile Gln Val Leu Asp Ala Phe Leu Cys Ala Val Gly Leu Thr
465                 470                 475                 480 
Ser Tyr Ser Val Leu Val Ile Arg Ile Val Gln Pro Glu Leu Lys Ala
                485                 490                 495     
Leu Ala Ile Gly Phe His Ser Met Ile Met Arg Ser Leu Gly Gly Ile
            500                 505                 510         
Leu Val Pro Ile Tyr Phe Gly Ala Leu Ile Asp Thr Thr Cys Met Lys
        515                 520                 525             
Trp Ser Thr Asn Ser Cys Gly Ala Arg Gly Ala Cys Arg Ile Tyr Asn
    530                 535                 540                 
Ser Thr Tyr Leu Gly Arg Ala Phe Phe Gly Leu Lys Val Ala Leu Ile
545                 550                 555                 560 
Phe Pro Val Leu Val Leu Leu Thr Val Phe Ile Phe Val Val Arg Lys
                565                 570                 575     
Lys Ser His Gly Lys Asp Thr Lys Val Leu Glu Asn Glu Arg Gln Val
            580                 585                 590         
Met Asp Glu Ala Asn Leu Glu Phe Leu Asn Asp Ser Glu His Phe Val
        595                 600                 605             
Pro Ser Ala Glu Glu Gln
    610                 


<210> 9159
<211> 318
<212> PRT
<213> Homo sapiens

<400> 9159
Met Asp Lys Ile Asn Gln Thr Phe Val Arg Glu Phe Ile Leu Leu Gly
 1               5                  10                  15      
Leu Ser Gly Tyr Pro Lys Leu Glu Ile Ile Phe Phe Ala Leu Ile Leu
            20                  25                  30          
Val Met Tyr Val Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala
        35                  40                  45              
Ser Ile Leu Asp Ser Arg Leu His Met Pro Met Tyr Phe Phe Leu Gly
    50                  55                  60                  
Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Ser
65                  70                  75                  80  
Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly
                85                  90                  95      
Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys
            100                 105                 110         
Phe Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn
        115                 120                 125             
Pro Leu Arg Tyr Pro Ile Ile Met Asn Lys Val Val Tyr Val Leu Leu
    130                 135                 140                 
Thr Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Thr Val Gln Thr
145                 150                 155                 160 
Ser Leu Ala Met Arg Trp Pro Phe Cys Gly Asn Asn Ile Ile Asn His
                165                 170                 175     
Phe Leu Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ser Asp Ile
            180                 185                 190         
Ser Val Asn Ile Val Thr Leu Ala Val Ser Asn Ile Ala Phe Leu Val
        195                 200                 205             
Leu Pro Leu Leu Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr
    210                 215                 220                 
Ile Leu Arg Thr Asn Ser Ala Thr Gly Arg His Lys Ala Phe Ser Thr
225                 230                 235                 240 
Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe
                245                 250                 255     
Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp Leu Leu Gly Lys Asp Asn
            260                 265                 270         
Leu Gln Ala Thr Glu Gly Leu Val Ser Met Phe Tyr Gly Val Val Thr
        275                 280                 285             
Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys
    290                 295                 300                 
Ala Ala Ile Lys Tyr Leu Leu Ser Arg Lys Ala Ile Asn Gln
305                 310                 315             


<210> 9160
<211> 378
<212> PRT
<213> Homo sapiens

<400> 9160
Met Arg Met Leu Val Ser Gly Arg Arg Val Lys Lys Trp Gln Leu Ile
 1               5                  10                  15      
Ile Gln Leu Phe Ala Thr Cys Phe Leu Ala Ser Leu Met Phe Phe Trp
            20                  25                  30          
Glu Pro Ile Asp Asn His Ile Val Ser His Met Lys Ser Tyr Ser Tyr
        35                  40                  45              
Arg Tyr Leu Ile Asn Ser Tyr Asp Phe Val Asn Asp Thr Leu Ser Leu
    50                  55                  60                  
Lys His Thr Ser Ala Gly Pro Arg Tyr Gln Tyr Leu Ile Asn His Lys
65                  70                  75                  80  
Glu Lys Cys Gln Ala Gln Asp Val Leu Leu Leu Leu Phe Val Lys Thr
                85                  90                  95      
Ala Pro Glu Asn Tyr Asp Arg Arg Ser Gly Ile Arg Arg Thr Trp Gly
            100                 105                 110         
Asn Glu Asn Tyr Val Arg Ser Gln Leu Asn Ala Asn Ile Lys Thr Leu
        115                 120                 125             
Phe Ala Leu Gly Thr Pro Asn Pro Leu Glu Gly Glu Glu Leu Gln Arg
    130                 135                 140                 
Lys Leu Ala Trp Glu Asp Gln Arg Tyr Asn Asp Ile Ile Gln Gln Asp
145                 150                 155                 160 
Phe Val Asp Ser Phe Tyr Asn Leu Thr Leu Lys Leu Leu Met Gln Phe
                165                 170                 175     
Ser Trp Ala Asn Thr Tyr Cys Pro His Ala Lys Phe Leu Met Thr Ala
            180                 185                 190         
Asp Asp Asp Ile Phe Ile His Met Pro Asn Leu Ile Glu Tyr Leu Gln
        195                 200                 205             
Ser Leu Glu Gln Ile Gly Val Gln Asp Phe Trp Ile Gly Arg Val His
    210                 215                 220                 
Arg Gly Ala Pro Pro Ile Arg Asp Lys Ser Ser Lys Tyr Tyr Val Ser
225                 230                 235                 240 
Tyr Glu Met Tyr Gln Trp Pro Ala Tyr Pro Asp Tyr Thr Ala Gly Ala
                245                 250                 255     
Ala Tyr Val Ile Ser Gly Asp Val Ala Ala Lys Val Tyr Glu Ala Ser
            260                 265                 270         
Gln Thr Leu Asn Ser Ser Leu Tyr Ile Asp Asp Val Phe Met Gly Leu
        275                 280                 285             
Cys Ala Asn Lys Ile Gly Ile Val Pro Gln Asp His Val Phe Phe Ser
    290                 295                 300                 
Gly Glu Gly Lys Thr Pro Tyr His Pro Cys Ile Tyr Glu Lys Met Met
305                 310                 315                 320 
Thr Ser His Gly His Leu Glu Asp Leu Gln Asp Leu Trp Lys Asn Ala
                325                 330                 335     
Thr Asp Pro Lys Val Lys Thr Ile Ser Lys Gly Phe Phe Gly Gln Ile
            340                 345                 350         
Tyr Cys Arg Leu Met Lys Ile Ile Leu Leu Cys Lys Ile Ser Tyr Val
        355                 360                 365             
Asp Thr Tyr Pro Cys Arg Ala Ala Phe Ile
    370                 375             


<210> 9161
<211> 1337
<212> PRT
<213> Homo sapiens

<400> 9161
Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys
 1               5                  10                  15      
Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu
            20                  25                  30          
Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn
        35                  40                  45              
Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys
    50                  55                  60                  
Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp
65                  70                  75                  80  
Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu
                85                  90                  95      
Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val
            100                 105                 110         
Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu
        115                 120                 125             
Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile
    130                 135                 140                 
Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu
145                 150                 155                 160 
Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr
                165                 170                 175     
Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr
            180                 185                 190         
Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp
        195                 200                 205             
Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly
    210                 215                 220                 
Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr
225                 230                 235                 240 
Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val
                245                 250                 255     
Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His
            260                 265                 270         
Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe
        275                 280                 285             
Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala
    290                 295                 300                 
Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr
305                 310                 315                 320 
Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro
                325                 330                 335     
Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val
            340                 345                 350         
Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val
        355                 360                 365             
Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr
    370                 375                 380                 
Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr
385                 390                 395                 400 
Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe
                405                 410                 415     
Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr
            420                 425                 430         
Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln
        435                 440                 445             
Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro
    450                 455                 460                 
Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser
465                 470                 475                 480 
Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly
                485                 490                 495     
Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu
            500                 505                 510         
Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu
        515                 520                 525             
Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp
    530                 535                 540                 
Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile
545                 550                 555                 560 
Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn
                565                 570                 575     
Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile
            580                 585                 590         
Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser
        595                 600                 605             
Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val
    610                 615                 620                 
Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr
625                 630                 635                 640 
Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser
                645                 650                 655     
Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val
            660                 665                 670         
Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser
        675                 680                 685             
Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp
    690                 695                 700                 
Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr
705                 710                 715                 720 
Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met
                725                 730                 735     
Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys
            740                 745                 750         
Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val
        755                 760                 765             
Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu
    770                 775                 780                 
Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile
785                 790                 795                 800 
Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala
                805                 810                 815     
Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala
            820                 825                 830         
Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn
        835                 840                 845             
Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met
    850                 855                 860                 
Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn
865                 870                 875                 880 
Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val
                885                 890                 895     
Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu
            900                 905                 910         
Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe
        915                 920                 925             
Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro
    930                 935                 940                 
Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His
945                 950                 955                 960 
His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp
                965                 970                 975     
Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser
            980                 985                 990         
Asp Cys Gly Tyr Pro Val Thr Thr Phe Glu Val Pro Val Ser Val His
        995                 1000                1005            
Thr Arg Pro Pro Met Lys Glu Val Val Arg Ser Cys Thr Pro Met Lys
    1010                1015                1020                
Glu Ser Thr Thr Met Glu Ile Trp Ile His Pro Gln Pro Gln Ser Gln
1025                1030                1035                1040
Arg Arg Val Thr Phe His Leu Pro Glu Gly Ser Gln Glu Ser Ser Ser
                1045                1050                1055    
Asp Gly Gly Leu Gly Asp His Asp Ala Gly Ser Leu Thr Ser Thr Ser
            1060                1065                1070        
His Gly Leu Pro Leu Gly Tyr Pro Gln Glu Glu Tyr Phe Asp Arg Ala
        1075                1080                1085            
Thr Pro Ser Asn Arg Thr Glu Gly Asp Gly Asn Ser Asp Pro Glu Ser
    1090                1095                1100                
Thr Phe Ile Pro Gly Leu Lys Lys Ala Ala Glu Ile Thr Val Gln Pro
1105                1110                1115                1120
Thr Val Glu Glu Ala Ser Asp Asn Cys Thr Gln Glu Cys Leu Ile Tyr
                1125                1130                1135    
Gly His Ser Asp Ala Cys Trp Met Pro Ala Ser Leu Asp His Ser Ser
            1140                1145                1150        
Ser Ser Gln Ala Gln Ala Ser Ala Leu Cys His Ser Pro Pro Leu Ser
        1155                1160                1165            
Gln Ala Ser Thr Gln His His Ser Pro Arg Val Thr Gln Thr Ile Ala
    1170                1175                1180                
Leu Cys His Ser Pro Pro Val Thr Gln Thr Ile Ala Leu Cys His Ser
1185                1190                1195                1200
Pro Pro Pro Ile Gln Val Ser Ala Leu His His Ser Pro Pro Leu Val
                1205                1210                1215    
Gln Ala Thr Ala Leu His His Ser Pro Pro Ser Ala Gln Ala Ser Ala
            1220                1225                1230        
Leu Cys Tyr Ser Pro Pro Leu Ala Gln Ala Ala Ala Ile Ser His Ser
        1235                1240                1245            
Ser Pro Leu Pro Gln Val Ile Ala Leu His Arg Ser Gln Ala Gln Ser
    1250                1255                1260                
Ser Val Ser Leu Gln Gln Gly Trp Val Gln Gly Ala Asp Gly Leu Cys
1265                1270                1275                1280
Ser Val Asp Gln Gly Val Gln Gly Ser Ala Thr Ser Gln Phe Tyr Thr
                1285                1290                1295    
Met Ser Glu Arg Leu His Pro Ser Asp Asp Ser Ile Lys Val Ile Pro
            1300                1305                1310        
Leu Thr Thr Phe Thr Pro Arg Gln Gln Ala Arg Pro Ser Arg Gly Asp
        1315                1320                1325            
Ser Pro Ile Met Glu Glu His Pro Leu
    1330                1335        


<210> 9162
<211> 1347
<212> PRT
<213> Homo sapiens

<400> 9162
Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys
 1               5                  10                  15      
Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu
            20                  25                  30          
Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn
        35                  40                  45              
Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys
    50                  55                  60                  
Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp
65                  70                  75                  80  
Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu
                85                  90                  95      
Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val
            100                 105                 110         
Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu
        115                 120                 125             
Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile
    130                 135                 140                 
Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu
145                 150                 155                 160 
Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr
                165                 170                 175     
Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr
            180                 185                 190         
Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp
        195                 200                 205             
Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly
    210                 215                 220                 
Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr
225                 230                 235                 240 
Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val
                245                 250                 255     
Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His
            260                 265                 270         
Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe
        275                 280                 285             
Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala
    290                 295                 300                 
Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr
305                 310                 315                 320 
Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro
                325                 330                 335     
Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val
            340                 345                 350         
Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val
        355                 360                 365             
Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr
    370                 375                 380                 
Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr
385                 390                 395                 400 
Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe
                405                 410                 415     
Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr
            420                 425                 430         
Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln
        435                 440                 445             
Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro
    450                 455                 460                 
Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser
465                 470                 475                 480 
Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly
                485                 490                 495     
Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu
            500                 505                 510         
Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu
        515                 520                 525             
Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp
    530                 535                 540                 
Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile
545                 550                 555                 560 
Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn
                565                 570                 575     
Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile
            580                 585                 590         
Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser
        595                 600                 605             
Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val
    610                 615                 620                 
Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr
625                 630                 635                 640 
Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser
                645                 650                 655     
Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val
            660                 665                 670         
Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser
        675                 680                 685             
Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp
    690                 695                 700                 
Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr
705                 710                 715                 720 
Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met
                725                 730                 735     
Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys
            740                 745                 750         
Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val
        755                 760                 765             
Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu
    770                 775                 780                 
Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile
785                 790                 795                 800 
Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala
                805                 810                 815     
Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala
            820                 825                 830         
Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn
        835                 840                 845             
Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met
    850                 855                 860                 
Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn
865                 870                 875                 880 
Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val
                885                 890                 895     
Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu
            900                 905                 910         
Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe
        915                 920                 925             
Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro
    930                 935                 940                 
Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His
945                 950                 955                 960 
His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp
                965                 970                 975     
Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser
            980                 985                 990         
Asp Cys Gly Tyr Pro Val Thr Thr Phe Glu Val Pro Val Ser Val His
        995                 1000                1005            
Thr Arg Pro Pro Met Lys Glu Val Val Arg Ser Cys Thr Pro Met Lys
    1010                1015                1020                
Glu Ser Thr Thr Met Glu Ile Trp Ile His Pro Gln Pro Gln Arg Lys
1025                1030                1035                1040
Ser Glu Gly Lys Val Ala Gly Lys Ser Gln Arg Arg Val Thr Phe His
                1045                1050                1055    
Leu Pro Glu Gly Ser Gln Glu Ser Ser Ser Asp Gly Gly Leu Gly Asp
            1060                1065                1070        
His Asp Ala Gly Ser Leu Thr Ser Thr Ser His Gly Leu Pro Leu Gly
        1075                1080                1085            
Tyr Pro Gln Glu Glu Tyr Phe Asp Arg Ala Thr Pro Ser Asn Arg Thr
    1090                1095                1100                
Glu Gly Asp Gly Asn Ser Asp Pro Glu Ser Thr Phe Ile Pro Gly Leu
1105                1110                1115                1120
Lys Lys Ala Ala Glu Ile Thr Val Gln Pro Thr Val Glu Glu Ala Ser
                1125                1130                1135    
Asp Asn Cys Thr Gln Glu Cys Leu Ile Tyr Gly His Ser Asp Ala Cys
            1140                1145                1150        
Trp Met Pro Ala Ser Leu Asp His Ser Ser Ser Ser Gln Ala Gln Ala
        1155                1160                1165            
Ser Ala Leu Cys His Ser Pro Pro Leu Ser Gln Ala Ser Thr Gln His
    1170                1175                1180                
His Ser Pro Arg Val Thr Gln Thr Ile Ala Leu Cys His Ser Pro Pro
1185                1190                1195                1200
Val Thr Gln Thr Ile Ala Leu Cys His Ser Pro Pro Pro Ile Gln Val
                1205                1210                1215    
Ser Ala Leu His His Ser Pro Pro Leu Val Gln Ala Thr Ala Leu His
            1220                1225                1230        
His Ser Pro Pro Ser Ala Gln Ala Ser Ala Leu Cys Tyr Ser Pro Pro
        1235                1240                1245            
Leu Ala Gln Ala Ala Ala Ile Ser His Ser Ser Pro Leu Pro Gln Val
    1250                1255                1260                
Ile Ala Leu His Arg Ser Gln Ala Gln Ser Ser Val Ser Leu Gln Gln
1265                1270                1275                1280
Gly Trp Val Gln Gly Ala Asp Gly Leu Cys Ser Val Asp Gln Gly Val
                1285                1290                1295    
Gln Gly Ser Ala Thr Ser Gln Phe Tyr Thr Met Ser Glu Arg Leu His
            1300                1305                1310        
Pro Ser Asp Asp Ser Ile Lys Val Ile Pro Leu Thr Thr Phe Thr Pro
        1315                1320                1325            
Arg Gln Gln Ala Arg Pro Ser Arg Gly Asp Ser Pro Ile Met Glu Glu
    1330                1335                1340                
His Pro Leu
1345        


<210> 9163
<211> 1021
<212> PRT
<213> Homo sapiens

<400> 9163
Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys
 1               5                  10                  15      
Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu
            20                  25                  30          
Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn
        35                  40                  45              
Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys
    50                  55                  60                  
Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp
65                  70                  75                  80  
Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu
                85                  90                  95      
Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val
            100                 105                 110         
Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu
        115                 120                 125             
Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile
    130                 135                 140                 
Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu
145                 150                 155                 160 
Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr
                165                 170                 175     
Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr
            180                 185                 190         
Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp
        195                 200                 205             
Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly
    210                 215                 220                 
Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr
225                 230                 235                 240 
Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val
                245                 250                 255     
Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His
            260                 265                 270         
Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe
        275                 280                 285             
Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala
    290                 295                 300                 
Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr
305                 310                 315                 320 
Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro
                325                 330                 335     
Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val
            340                 345                 350         
Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val
        355                 360                 365             
Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr
    370                 375                 380                 
Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr
385                 390                 395                 400 
Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe
                405                 410                 415     
Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr
            420                 425                 430         
Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln
        435                 440                 445             
Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro
    450                 455                 460                 
Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser
465                 470                 475                 480 
Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly
                485                 490                 495     
Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu
            500                 505                 510         
Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu
        515                 520                 525             
Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp
    530                 535                 540                 
Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile
545                 550                 555                 560 
Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn
                565                 570                 575     
Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile
            580                 585                 590         
Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser
        595                 600                 605             
Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val
    610                 615                 620                 
Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr
625                 630                 635                 640 
Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser
                645                 650                 655     
Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val
            660                 665                 670         
Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser
        675                 680                 685             
Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp
    690                 695                 700                 
Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr
705                 710                 715                 720 
Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met
                725                 730                 735     
Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys
            740                 745                 750         
Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val
        755                 760                 765             
Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu
    770                 775                 780                 
Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile
785                 790                 795                 800 
Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala
                805                 810                 815     
Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala
            820                 825                 830         
Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn
        835                 840                 845             
Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met
    850                 855                 860                 
Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn
865                 870                 875                 880 
Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val
                885                 890                 895     
Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu
            900                 905                 910         
Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe
        915                 920                 925             
Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro
    930                 935                 940                 
Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His
945                 950                 955                 960 
His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp
                965                 970                 975     
Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser
            980                 985                 990         
Asp Cys Gly Tyr Pro Val Thr Thr Phe Glu Val Pro Val Ser Val His
        995                 1000                1005            
Thr Arg Pro Val Gly Ile Gln Val Ser Asn Thr Thr Phe
    1010                1015                1020    


<210> 9164
<211> 1037
<212> PRT
<213> Homo sapiens

<400> 9164
Met Thr Val Gly Phe Asn Ser Asp Ile Ser Ser Val Val Arg Val Asn
 1               5                  10                  15      
Thr Thr Asn Cys His Lys Cys Leu Leu Ser Gly Thr Tyr Ile Phe Ala
            20                  25                  30          
Val Leu Leu Val Cys Val Val Phe His Ser Gly Ala Gln Glu Lys Asn
        35                  40                  45              
Tyr Thr Ile Arg Glu Glu Ile Pro Glu Asn Val Leu Ile Gly Asn Leu
    50                  55                  60                  
Leu Lys Asp Leu Asn Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr
65                  70                  75                  80  
Thr Met Gln Phe Lys Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile
                85                  90                  95      
Arg Ile Glu Glu Asp Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile
            100                 105                 110         
Asp Arg Glu Lys Leu Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe
        115                 120                 125             
Tyr Glu Val Glu Val Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val
    130                 135                 140                 
Lys Ile Arg Phe Leu Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe
145                 150                 155                 160 
Pro Ala Thr Val Ile Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn
                165                 170                 175     
Ser Lys Tyr Thr Leu Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn
            180                 185                 190         
Gly Val Gln Asn Tyr Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu
        195                 200                 205             
Asp Val Ile Glu Thr Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val
    210                 215                 220                 
Gln Lys Glu Leu Asp Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val
225                 230                 235                 240 
Lys Val Glu Asp Gly Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu
                245                 250                 255     
Gln Val Ser Val Thr Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu
            260                 265                 270         
Thr Glu Ile Glu Val Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser
        275                 280                 285             
Val Thr Gln Leu His Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys
    290                 295                 300                 
Ile His Phe Ser Phe Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu
305                 310                 315                 320 
Phe His Leu Asn Ala Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu
                325                 330                 335     
Asp Arg Glu Glu Thr Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp
            340                 345                 350         
Gly Gly Leu Met Pro Ala Arg Ala Met Val Leu Val Asn Val Thr Asp
        355                 360                 365             
Val Asn Asp Asn Val Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro
    370                 375                 380                 
Val Asn Asp Thr Val Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys
385                 390                 395                 400 
Ile Ala Leu Ile Thr Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg
                405                 410                 415     
Val Thr Cys Phe Thr Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val
            420                 425                 430         
Phe Ser Asn Gln Phe Leu Leu Glu Asn Ala Ala Tyr Leu Asp Tyr Glu
        435                 440                 445             
Ser Thr Lys Glu Tyr Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys
    450                 455                 460                 
Pro Pro Leu Asn Gln Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu
465                 470                 475                 480 
Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile
                485                 490                 495     
Pro Glu Asn Asn Ser Pro Gly Ile Gln Leu Met Lys Val Ser Ala Thr
            500                 505                 510         
Asp Ala Asp Ser Gly Pro Asn Ala Glu Ile Asn Tyr Leu Leu Gly Pro
        515                 520                 525             
Asp Ala Pro Pro Glu Phe Ser Leu Asp Arg Arg Thr Gly Met Leu Thr
    530                 535                 540                 
Val Val Lys Lys Leu Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr
545                 550                 555                 560 
Ile Leu Ala Lys Asp Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr
                565                 570                 575     
Val Phe Val Ser Ile Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr
            580                 585                 590         
His Asn Glu Tyr Lys Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly
        595                 600                 605             
Thr Val Gly Leu Ile Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser
    610                 615                 620                 
Ala Val Thr Leu Ser Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp
625                 630                 635                 640 
Ser Gln Thr Gly Val Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys
                645                 650                 655     
Gln Glu Ser Tyr Thr Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val
            660                 665                 670         
Ser Arg Ser Ser Ser Ala Lys Val Thr Ile Asn Val Val Asp Val Asn
        675                 680                 685             
Asp Asn Lys Pro Val Phe Ile Val Pro Pro Tyr Asn Tyr Ser Tyr Glu
    690                 695                 700                 
Leu Val Leu Pro Ser Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile
705                 710                 715                 720 
Ala Val Asp Asn Asp Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile
                725                 730                 735     
Val Gly Gly Asn Thr Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly
            740                 745                 750         
Asn Ile Thr Leu Met Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His
        755                 760                 765             
Arg Val Leu Val Lys Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe
    770                 775                 780                 
Ser Val Val Ile Val Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala
785                 790                 795                 800 
Thr Leu Ile Asn Glu Leu Val Arg Lys Ser Ile Glu Ala Pro Val Thr
                805                 810                 815     
Pro Asn Thr Glu Ile Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val
            820                 825                 830         
Lys Ile Leu Val Ala Ala Val Ala Gly Thr Ile Thr Val Val Val Val
        835                 840                 845             
Ile Phe Ile Thr Ala Val Val Arg Cys Arg Gln Ala Pro His Leu Lys
    850                 855                 860                 
Ala Ala Gln Lys Asn Met Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro
865                 870                 875                 880 
Glu Asn Arg Gln Met Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys
                885                 890                 895     
His Ser Pro Lys Asn Leu Leu Leu Asn Val Val Thr Ile Glu Glu Thr
            900                 905                 910         
Lys Ala Asp Asp Val Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu
        915                 920                 925             
Pro Ile Asp Leu Glu Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr
    930                 935                 940                 
Thr Pro Thr Thr Phe Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr
945                 950                 955                 960 
Lys Ser Ala Ser Pro Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro
                965                 970                 975     
Leu Asn Leu Lys His His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr
            980                 985                 990         
Phe Val Ala Cys Asp Ser Ile Ser Asn Cys Ser Ser Ser Ser Ser Asp
        995                 1000                1005            
Pro Tyr Ser Val Ser Asp Cys Gly Tyr Pro Val Thr Thr Phe Glu Val
    1010                1015                1020                
Pro Val Ser Val His Thr Arg Pro Thr Asp Ser Arg Thr
1025                1030                1035        


<210> 9165
<211> 1340
<212> PRT
<213> Homo sapiens

<400> 9165
Met Phe Arg Val Gly Phe Leu Ile Ile Ser Ser Ser Ser Ser Leu Ser
 1               5                  10                  15      
Pro Leu Leu Leu Val Ser Val Val Arg Val Asn Thr Thr Asn Cys His
            20                  25                  30          
Lys Cys Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Val Cys
        35                  40                  45              
Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu
    50                  55                  60                  
Glu Ile Pro Glu Asn Val Leu Ile Gly Asn Leu Leu Lys Asp Leu Asn
65                  70                  75                  80  
Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Thr Met Gln Phe Lys
                85                  90                  95      
Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp
            100                 105                 110         
Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu
        115                 120                 125             
Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val
    130                 135                 140                 
Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu
145                 150                 155                 160 
Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile
                165                 170                 175     
Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu
            180                 185                 190         
Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr
        195                 200                 205             
Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr
    210                 215                 220                 
Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp
225                 230                 235                 240 
Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly
                245                 250                 255     
Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr
            260                 265                 270         
Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val
        275                 280                 285             
Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His
    290                 295                 300                 
Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe
305                 310                 315                 320 
Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala
                325                 330                 335     
Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr
            340                 345                 350         
Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro
        355                 360                 365             
Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val
    370                 375                 380                 
Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val
385                 390                 395                 400 
Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr
                405                 410                 415     
Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr
            420                 425                 430         
Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe
        435                 440                 445             
Leu Leu Glu Asn Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr
    450                 455                 460                 
Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln
465                 470                 475                 480 
Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro
                485                 490                 495     
Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser
            500                 505                 510         
Pro Gly Ile Gln Leu Met Lys Val Ser Ala Thr Asp Ala Asp Ser Gly
        515                 520                 525             
Pro Asn Ala Glu Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu
    530                 535                 540                 
Phe Ser Leu Asp Arg Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu
545                 550                 555                 560 
Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp
                565                 570                 575     
Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile
            580                 585                 590         
Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Lys
        595                 600                 605             
Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile
    610                 615                 620                 
Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser
625                 630                 635                 640 
Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val
                645                 650                 655     
Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr
            660                 665                 670         
Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser
        675                 680                 685             
Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val
    690                 695                 700                 
Phe Ile Val Pro Pro Tyr Asn Tyr Ser Tyr Glu Leu Val Leu Pro Ser
705                 710                 715                 720 
Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp
                725                 730                 735     
Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr
            740                 745                 750         
Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met
        755                 760                 765             
Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys
    770                 775                 780                 
Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val
785                 790                 795                 800 
Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu
                805                 810                 815     
Leu Val Arg Lys Ser Ile Glu Ala Pro Val Thr Pro Asn Thr Glu Ile
            820                 825                 830         
Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala
        835                 840                 845             
Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala
    850                 855                 860                 
Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn
865                 870                 875                 880 
Met Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met
                885                 890                 895     
Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn
            900                 905                 910         
Leu Leu Leu Asn Val Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val
        915                 920                 925             
Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu
    930                 935                 940                 
Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe
945                 950                 955                 960 
Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro
                965                 970                 975     
Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Leu Lys His
            980                 985                 990         
His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp
        995                 1000                1005            
Ser Ile Ser Asn Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser
    1010                1015                1020                
Asp Cys Gly Tyr Pro Val Thr Thr Phe Glu Val Pro Val Ser Val His
1025                1030                1035                1040
Thr Arg Pro Ser Gln Arg Arg Val Thr Phe His Leu Pro Glu Gly Ser
                1045                1050                1055    
Gln Glu Ser Ser Ser Asp Gly Gly Leu Gly Asp His Asp Ala Gly Ser
            1060                1065                1070        
Leu Thr Ser Thr Ser His Gly Leu Pro Leu Gly Tyr Pro Gln Glu Glu
        1075                1080                1085            
Tyr Phe Asp Arg Ala Thr Pro Ser Asn Arg Thr Glu Gly Asp Gly Asn
    1090                1095                1100                
Ser Asp Pro Glu Ser Thr Phe Ile Pro Gly Leu Lys Lys Glu Ile Thr
1105                1110                1115                1120
Val Gln Pro Thr Val Glu Glu Ala Ser Asp Asn Cys Thr Gln Glu Cys
                1125                1130                1135    
Leu Ile Tyr Gly His Ser Asp Ala Cys Trp Met Pro Ala Ser Leu Asp
            1140                1145                1150        
His Ser Ser Ser Ser Gln Ala Gln Ala Ser Ala Leu Cys His Ser Pro
        1155                1160                1165            
Pro Leu Ser Gln Ala Ser Thr Gln His His Ser Pro Pro Val Thr Gln
    1170                1175                1180                
Thr Ile Val Leu Cys His Ser Pro Pro Val Thr Gln Thr Ile Ala Leu
1185                1190                1195                1200
Cys His Ser Pro Pro Pro Ile Gln Val Ser Ala Leu His His Ser Pro
                1205                1210                1215    
Pro Leu Val Gln Gly Thr Ala Leu His His Ser Pro Pro Ser Ala Gln
            1220                1225                1230        
Ala Ser Ala Leu Cys Tyr Ser Pro Pro Leu Ala Gln Ala Ala Ala Ile
        1235                1240                1245            
Ser His Ser Ser Ser Leu Pro Gln Val Ile Ala Leu His Arg Ser Gln
    1250                1255                1260                
Ala Gln Ser Ser Val Ser Leu Gln Gln Gly Trp Val Gln Gly Ala Asn
1265                1270                1275                1280
Gly Leu Cys Ser Val Asp Gln Gly Val Gln Gly Ser Ala Thr Ser Gln
                1285                1290                1295    
Phe Tyr Thr Met Ser Glu Arg Leu His Pro Ser Asp Asp Ser Ile Lys
            1300                1305                1310        
Val Ile Pro Leu Thr Thr Phe Ala Pro Arg Gln Gln Ala Arg Pro Ser
        1315                1320                1325            
Arg Gly Asp Ser Pro Ile Met Glu Thr His Pro Leu
    1330                1335                1340


<210> 9166
<211> 1048
<212> PRT
<213> Homo sapiens

<400> 9166
Met Phe Arg Val Gly Phe Leu Ile Ile Ser Ser Ser Ser Ser Leu Ser
 1               5                  10                  15      
Pro Leu Leu Leu Val Ser Val Val Arg Val Asn Thr Thr Asn Cys His
            20                  25                  30          
Lys Cys Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Val Cys
        35                  40                  45              
Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu
    50                  55                  60                  
Glu Ile Pro Glu Asn Val Leu Ile Gly Asn Leu Leu Lys Asp Leu Asn
65                  70                  75                  80  
Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Thr Met Gln Phe Lys
                85                  90                  95      
Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp
            100                 105                 110         
Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu
        115                 120                 125             
Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val
    130                 135                 140                 
Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu
145                 150                 155                 160 
Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile
                165                 170                 175     
Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu
            180                 185                 190         
Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr
        195                 200                 205             
Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr
    210                 215                 220                 
Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp
225                 230                 235                 240 
Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly
                245                 250                 255     
Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr
            260                 265                 270         
Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val
        275                 280                 285             
Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His
    290                 295                 300                 
Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe
305                 310                 315                 320 
Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala
                325                 330                 335     
Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr
            340                 345                 350         
Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro
        355                 360                 365             
Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val
    370                 375                 380                 
Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val
385                 390                 395                 400 
Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr
                405                 410                 415     
Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr
            420                 425                 430         
Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe
        435                 440                 445             
Leu Leu Glu Asn Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr
    450                 455                 460                 
Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln
465                 470                 475                 480 
Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro
                485                 490                 495     
Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser
            500                 505                 510         
Pro Gly Ile Gln Leu Met Lys Val Ser Ala Thr Asp Ala Asp Ser Gly
        515                 520                 525             
Pro Asn Ala Glu Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu
    530                 535                 540                 
Phe Ser Leu Asp Arg Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu
545                 550                 555                 560 
Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp
                565                 570                 575     
Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile
            580                 585                 590         
Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Lys
        595                 600                 605             
Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile
    610                 615                 620                 
Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser
625                 630                 635                 640 
Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val
                645                 650                 655     
Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr
            660                 665                 670         
Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser
        675                 680                 685             
Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val
    690                 695                 700                 
Phe Ile Val Pro Pro Tyr Asn Tyr Ser Tyr Glu Leu Val Leu Pro Ser
705                 710                 715                 720 
Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp
                725                 730                 735     
Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr
            740                 745                 750         
Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met
        755                 760                 765             
Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys
    770                 775                 780                 
Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val
785                 790                 795                 800 
Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu
                805                 810                 815     
Leu Val Arg Lys Ser Ile Glu Ala Pro Val Thr Pro Asn Thr Glu Ile
            820                 825                 830         
Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala
        835                 840                 845             
Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala
    850                 855                 860                 
Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn
865                 870                 875                 880 
Met Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met
                885                 890                 895     
Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn
            900                 905                 910         
Leu Leu Leu Asn Val Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val
        915                 920                 925             
Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu
    930                 935                 940                 
Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe
945                 950                 955                 960 
Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro
                965                 970                 975     
Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Leu Lys His
            980                 985                 990         
His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp
        995                 1000                1005            
Ser Ile Ser Asn Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser
    1010                1015                1020                
Asp Cys Gly Tyr Pro Val Thr Thr Phe Glu Val Pro Val Ser Val His
1025                1030                1035                1040
Thr Arg Pro Thr Asp Ser Arg Thr
                1045            


<210> 9167
<211> 1025
<212> PRT
<213> Homo sapiens

<400> 9167
Met Asp Leu Leu Ser Gly Thr Tyr Ile Phe Ala Val Leu Leu Ala Cys
 1               5                  10                  15      
Val Val Phe His Ser Gly Ala Gln Glu Lys Asn Tyr Thr Ile Arg Glu
            20                  25                  30          
Glu Met Pro Glu Asn Val Leu Ile Gly Asp Leu Leu Lys Asp Leu Asn
        35                  40                  45              
Leu Ser Leu Ile Pro Asn Lys Ser Leu Thr Thr Ala Met Gln Phe Lys
    50                  55                  60                  
Leu Val Tyr Lys Thr Gly Asp Val Pro Leu Ile Arg Ile Glu Glu Asp
65                  70                  75                  80  
Thr Gly Glu Ile Phe Thr Thr Gly Ala Arg Ile Asp Arg Glu Lys Leu
                85                  90                  95      
Cys Ala Gly Ile Pro Arg Asp Glu His Cys Phe Tyr Glu Val Glu Val
            100                 105                 110         
Ala Ile Leu Pro Asp Glu Ile Phe Arg Leu Val Lys Ile Arg Phe Leu
        115                 120                 125             
Ile Glu Asp Ile Asn Asp Asn Ala Pro Leu Phe Pro Ala Thr Val Ile
    130                 135                 140                 
Asn Ile Ser Ile Pro Glu Asn Ser Ala Ile Asn Ser Lys Tyr Thr Leu
145                 150                 155                 160 
Pro Ala Ala Val Asp Pro Asp Val Gly Ile Asn Gly Val Gln Asn Tyr
                165                 170                 175     
Glu Leu Ile Lys Ser Gln Asn Ile Phe Gly Leu Asp Val Ile Glu Thr
            180                 185                 190         
Pro Glu Gly Asp Lys Met Pro Gln Leu Ile Val Gln Lys Glu Leu Asp
        195                 200                 205             
Arg Glu Glu Lys Asp Thr Tyr Val Met Lys Val Lys Val Glu Asp Gly
    210                 215                 220                 
Gly Phe Pro Gln Arg Ser Ser Thr Ala Ile Leu Gln Val Ser Val Thr
225                 230                 235                 240 
Asp Thr Asn Asp Asn His Pro Val Phe Lys Glu Thr Glu Ile Glu Val
                245                 250                 255     
Ser Ile Pro Glu Asn Ala Pro Val Gly Thr Ser Val Thr Gln Leu His
            260                 265                 270         
Ala Thr Asp Ala Asp Ile Gly Glu Asn Ala Lys Ile His Phe Ser Phe
        275                 280                 285             
Ser Asn Leu Val Ser Asn Ile Ala Arg Arg Leu Phe His Leu Asn Ala
    290                 295                 300                 
Thr Thr Gly Leu Ile Thr Ile Lys Glu Pro Leu Asp Arg Glu Glu Thr
305                 310                 315                 320 
Pro Asn His Lys Leu Leu Val Leu Ala Ser Asp Gly Gly Leu Met Pro
                325                 330                 335     
Ala Arg Ala Met Val Leu Val Asn Val Thr Asp Val Asn Asp Asn Val
            340                 345                 350         
Pro Ser Ile Asp Ile Arg Tyr Ile Val Asn Pro Val Asn Asp Thr Val
        355                 360                 365             
Val Leu Ser Glu Asn Ile Pro Leu Asn Thr Lys Ile Ala Leu Ile Thr
    370                 375                 380                 
Val Thr Asp Lys Asp Ala Asp His Asn Gly Arg Val Thr Cys Phe Thr
385                 390                 395                 400 
Asp His Glu Ile Pro Phe Arg Leu Arg Pro Val Phe Ser Asn Gln Phe
                405                 410                 415     
Leu Leu Glu Thr Ala Ala Tyr Leu Asp Tyr Glu Ser Thr Lys Glu Tyr
            420                 425                 430         
Ala Ile Lys Leu Leu Ala Ala Asp Ala Gly Lys Pro Pro Leu Asn Gln
        435                 440                 445             
Ser Ala Met Leu Phe Ile Lys Val Lys Asp Glu Asn Asp Asn Ala Pro
    450                 455                 460                 
Val Phe Thr Gln Ser Phe Val Thr Val Ser Ile Pro Glu Asn Asn Ser
465                 470                 475                 480 
Pro Gly Ile Gln Leu Thr Lys Val Ser Ala Met Asp Ala Asp Ser Gly
                485                 490                 495     
Pro Asn Ala Lys Ile Asn Tyr Leu Leu Gly Pro Asp Ala Pro Pro Glu
            500                 505                 510         
Phe Ser Leu Asp Cys Arg Thr Gly Met Leu Thr Val Val Lys Lys Leu
        515                 520                 525             
Asp Arg Glu Lys Glu Asp Lys Tyr Leu Phe Thr Ile Leu Ala Lys Asp
    530                 535                 540                 
Asn Gly Val Pro Pro Leu Thr Ser Asn Val Thr Val Phe Val Ser Ile
545                 550                 555                 560 
Ile Asp Gln Asn Asp Asn Ser Pro Val Phe Thr His Asn Glu Tyr Asn
                565                 570                 575     
Phe Tyr Val Pro Glu Asn Leu Pro Arg His Gly Thr Val Gly Leu Ile
            580                 585                 590         
Thr Val Thr Asp Pro Asp Tyr Gly Asp Asn Ser Ala Val Thr Leu Ser
        595                 600                 605             
Ile Leu Asp Glu Asn Asp Asp Phe Thr Ile Asp Ser Gln Thr Gly Val
    610                 615                 620                 
Ile Arg Pro Asn Ile Ser Phe Asp Arg Glu Lys Gln Glu Ser Tyr Thr
625                 630                 635                 640 
Phe Tyr Val Lys Ala Glu Asp Gly Gly Arg Val Ser Arg Ser Ser Ser
                645                 650                 655     
Ala Lys Val Thr Ile Asn Val Val Asp Val Asn Asp Asn Lys Pro Val
            660                 665                 670         
Phe Ile Val Pro Pro Ser Asn Cys Ser Tyr Glu Leu Val Leu Pro Ser
        675                 680                 685             
Thr Asn Pro Gly Thr Val Val Phe Gln Val Ile Ala Val Asp Asn Asp
    690                 695                 700                 
Thr Gly Met Asn Ala Glu Val Arg Tyr Ser Ile Val Gly Gly Asn Thr
705                 710                 715                 720 
Arg Asp Leu Phe Ala Ile Asp Gln Glu Thr Gly Asn Ile Thr Leu Met
                725                 730                 735     
Glu Lys Cys Asp Val Thr Asp Leu Gly Leu His Arg Val Leu Val Lys
            740                 745                 750         
Ala Asn Asp Leu Gly Gln Pro Asp Ser Leu Phe Ser Val Val Ile Val
        755                 760                 765             
Asn Leu Phe Val Asn Glu Ser Val Thr Asn Ala Thr Leu Ile Asn Glu
    770                 775                 780                 
Leu Val Arg Lys Ser Thr Glu Ala Pro Val Thr Pro Asn Thr Glu Ile
785                 790                 795                 800 
Ala Asp Val Ser Ser Pro Thr Ser Asp Tyr Val Lys Ile Leu Val Ala
                805                 810                 815     
Ala Val Ala Gly Thr Ile Thr Val Val Val Val Ile Phe Ile Thr Ala
            820                 825                 830         
Val Val Arg Cys Arg Gln Ala Pro His Leu Lys Ala Ala Gln Lys Asn
        835                 840                 845             
Lys Gln Asn Ser Glu Trp Ala Thr Pro Asn Pro Glu Asn Arg Gln Met
    850                 855                 860                 
Ile Met Met Lys Lys Lys Lys Lys Lys Lys Lys His Ser Pro Lys Asn
865                 870                 875                 880 
Leu Leu Leu Asn Phe Val Thr Ile Glu Glu Thr Lys Ala Asp Asp Val
                885                 890                 895     
Asp Ser Asp Gly Asn Arg Val Thr Leu Asp Leu Pro Ile Asp Leu Glu
            900                 905                 910         
Glu Gln Thr Met Gly Lys Tyr Asn Trp Val Thr Thr Pro Thr Thr Phe
        915                 920                 925             
Lys Pro Asp Ser Pro Asp Leu Ala Arg His Tyr Lys Ser Ala Ser Pro
    930                 935                 940                 
Gln Pro Ala Phe Gln Ile Gln Pro Glu Thr Pro Leu Asn Ser Lys His
945                 950                 955                 960 
His Ile Ile Gln Glu Leu Pro Leu Asp Asn Thr Phe Val Ala Cys Asp
                965                 970                 975     
Ser Ile Ser Lys Cys Ser Ser Ser Ser Ser Asp Pro Tyr Ser Val Ser
            980                 985                 990         
Asp Cys Gly Tyr Pro Val Thr Thr Phe Glu Val Pro Val Ser Val His
        995                 1000                1005            
Thr Arg Pro Thr Asp Ser Arg Thr Ser Thr Ile Glu Ile Cys Ser Glu
    1010                1015                1020                
Ile
1025


<210> 9168
<211> 641
<212> PRT
<213> Homo sapiens

<400> 9168
Met Leu Leu Gly Ala Ser Leu Val Gly Val Leu Leu Phe Ser Lys Leu
 1               5                  10                  15      
Val Leu Lys Leu Pro Trp Thr Gln Val Gly Phe Ser Leu Leu Phe Leu
            20                  25                  30          
Tyr Leu Gly Ser Gly Gly Trp Arg Phe Ile Arg Val Phe Ile Lys Thr
        35                  40                  45              
Ile Arg Arg Asp Ile Phe Gly Gly Leu Val Leu Leu Lys Val Lys Ala
    50                  55                  60                  
Lys Val Arg Gln Cys Leu Gln Glu Arg Arg Thr Val Pro Ile Leu Phe
65                  70                  75                  80  
Ala Ser Thr Val Arg Arg His Pro Asp Lys Thr Ala Leu Ile Phe Glu
                85                  90                  95      
Gly Thr Asp Thr His Trp Thr Phe Arg Gln Leu Asp Glu Tyr Ser Ser
            100                 105                 110         
Ser Val Ala Asn Phe Leu Gln Ala Arg Gly Leu Ala Ser Gly Asp Val
        115                 120                 125             
Ala Ala Ile Phe Met Glu Asn Arg Asn Glu Phe Val Gly Leu Trp Leu
    130                 135                 140                 
Gly Met Ala Lys Leu Gly Val Glu Ala Ala Leu Ile Asn Thr Asn Leu
145                 150                 155                 160 
Arg Arg Asp Ala Leu Leu His Cys Leu Thr Thr Ser Arg Ala Arg Ala
                165                 170                 175     
Leu Val Phe Gly Ser Glu Met Ala Ser Ala Ile Cys Glu Val His Ala
            180                 185                 190         
Ser Pro Asp Pro Ser Leu Ser Leu Phe Cys Ser Gly Ser Trp Glu Pro
        195                 200                 205             
Gly Ala Val Pro Pro Ser Thr Glu His Leu Asp Pro Leu Leu Lys Asp
    210                 215                 220                 
Ala Pro Lys His Leu Pro Ser Cys Pro Asp Lys Gly Phe Thr Asp Lys
225                 230                 235                 240 
Leu Phe Tyr Ile Tyr Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala
                245                 250                 255     
Ile Val Val His Ser Arg Tyr Tyr Arg Met Ala Ala Leu Val Tyr Tyr
            260                 265                 270         
Gly Phe Arg Met Arg Pro Asn Asp Ile Val Tyr Asp Cys Leu Pro Leu
        275                 280                 285             
Tyr His Ser Ala Gly Asn Ile Val Gly Ile Gly Gln Cys Leu Leu His
    290                 295                 300                 
Gly Met Thr Val Val Ile Arg Lys Lys Phe Ser Ala Ser Arg Phe Trp
305                 310                 315                 320 
Asp Asp Cys Ile Lys Tyr Asn Cys Thr Ile Val Gln Tyr Ile Gly Glu
                325                 330                 335     
Leu Cys Arg Tyr Leu Leu Asn Gln Pro Pro Arg Glu Ala Glu Asn Gln
            340                 345                 350         
His Gln Val Arg Met Ala Leu Gly Asn Ala Ser Gly Ser Pro Ser Gly
        355                 360                 365             
Pro Thr Phe Pro Ala Ala Ser Thr Tyr Pro Arg Trp Leu Ser Ser Thr
    370                 375                 380                 
Gly Pro Glu Cys Asn Cys Ser Leu Gly Asn Phe Asp Ser Gln Val Gly
385                 390                 395                 400 
Ala Cys Gly Phe Asn Ser Arg Ile Leu Ser Phe Val Tyr Pro Ile Arg
                405                 410                 415     
Leu Val Arg Val Asn Glu Asp Thr Met Glu Leu Ile Arg Gly Pro Asp
            420                 425                 430         
Gly Val Cys Ile Pro Cys Gln Pro Gly Glu Pro Gly Gln Leu Val Gly
        435                 440                 445             
Arg Ile Ile Gln Lys Asp Pro Leu Arg Arg Phe Asp Gly Tyr Leu Asn
    450                 455                 460                 
Gln Gly Ala Asn Asn Lys Lys Ile Ala Lys Asp Val Phe Lys Lys Gly
465                 470                 475                 480 
Asp Gln Ala Tyr Leu Thr Gly Asp Val Leu Val Met Asp Glu Leu Gly
                485                 490                 495     
Tyr Leu Tyr Phe Arg Asp Arg Thr Gly Asp Thr Phe Arg Trp Lys Gly
            500                 505                 510         
Glu Asn Val Ser Thr Thr Glu Val Glu Gly Thr Leu Ser Arg Leu Leu
        515                 520                 525             
Asp Met Ala Asp Val Ala Val Tyr Gly Val Glu Val Pro Gly Thr Glu
    530                 535                 540                 
Gly Arg Ala Gly Met Ala Ala Val Ala Ser Pro Thr Gly Asn Cys Asp
545                 550                 555                 560 
Leu Glu Arg Phe Ala Gln Val Leu Glu Lys Glu Leu Pro Leu Tyr Ala
                565                 570                 575     
Arg Pro Ile Phe Leu Arg Leu Leu Pro Glu Leu His Lys Thr Gly Thr
            580                 585                 590         
Tyr Lys Phe Gln Lys Thr Glu Leu Arg Lys Glu Ala Phe Asp Pro Ala
        595                 600                 605             
Ile Val Lys Thr Arg Cys Ser Ile Tyr Ile Glu Lys Gly Arg Tyr Val
    610                 615                 620                 
Pro Leu Asp Gln Glu Ala Tyr Ser Arg Ile Gln Ala Gly Glu Glu Lys
625                 630                 635                 640 
Leu
    


<210> 9169
<211> 360
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 127, 175
<223> Xaa = Any Amino Acid

<400> 9169
Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr
 1               5                  10                  15      
Thr Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Pro Gln Asn Gly
            20                  25                  30          
Gly Asp Lys Leu Glu Thr Thr Pro Leu Tyr Leu Glu Glu Asp Ile Arg
        35                  40                  45              
Pro Asp Ile Lys Asp Asp Ile Tyr Asn Leu Thr Tyr Lys Asp Lys Glu
    50                  55                  60                  
Gly Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met
65                  70                  75                  80  
Ser Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr
                85                  90                  95      
Cys Asn Leu Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Ile Ser
            100                 105                 110         
Ala Leu Gly Ile Thr Ala Gly Ala His Pro Leu Trp Ser His Xaa Ser
        115                 120                 125             
Tyr Lys Ala Arg Leu Ser Leu Trp Leu Phe Leu Ile Ile Ala Asn Thr
    130                 135                 140                 
Met Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala
145                 150                 155                 160 
His His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Xaa Arg
                165                 170                 175     
Gly Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro
            180                 185                 190         
Thr Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala
        195                 200                 205             
Glu Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu
    210                 215                 220                 
Leu Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Cys Phe Trp Gly
225                 230                 235                 240 
Glu Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala
                245                 250                 255     
Val Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe
            260                 265                 270         
Arg Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Leu Arg Glu Asn Ile Leu
        275                 280                 285             
Val Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser
    290                 295                 300                 
Phe Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe
305                 310                 315                 320 
Thr Thr Phe Phe Ile Asp Cys Met Ala Ala Phe Gly Leu Ala Tyr Asp
                325                 330                 335     
Gln Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr
            340                 345                 350         
Gly Glu Gly Asn Tyr Lys Ser Gly
        355                 360 


<210> 9170
<211> 244
<212> PRT
<213> Homo sapiens

<400> 9170
Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg
 1               5                  10                  15      
Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu
            20                  25                  30          
Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro
        35                  40                  45              
Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln
    50                  55                  60                  
Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu
65                  70                  75                  80  
Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro
                85                  90                  95      
Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe
            100                 105                 110         
Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro
        115                 120                 125             
Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg
    130                 135                 140                 
Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg
145                 150                 155                 160 
Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu
                165                 170                 175     
Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala
            180                 185                 190         
Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly
        195                 200                 205             
Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser
    210                 215                 220                 
His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala
225                 230                 235                 240 
Val Met Val Gly
                


<210> 9171
<211> 469
<212> PRT
<213> Homo sapiens

<400> 9171
Met Ala Arg Gly Leu Gly Ala Pro His Trp Val Ala Val Gly Leu Leu
 1               5                  10                  15      
Thr Trp Ala Thr Leu Gly Leu Leu Val Ala Gly Leu Gly Gly His Asp
            20                  25                  30          
Asp Leu His Asp Asp Leu Gln Glu Asp Phe His Gly His Ser His Arg
        35                  40                  45              
His Ser His Glu Asp Phe His His Gly His Ser His Ala His Gly His
    50                  55                  60                  
Gly His Thr His Glu Ser Ile Trp His Gly His Thr His Asp His Asp
65                  70                  75                  80  
His Gly His Ser His Glu Asp Leu His His Gly His Ser His Gly Tyr
                85                  90                  95      
Ser His Glu Ser Leu Tyr His Arg Gly His Gly His Asp His Glu His
            100                 105                 110         
Ser His Gly Gly Tyr Gly Glu Ser Gly Ala Pro Gly Ile Lys Gln Asp
        115                 120                 125             
Leu Asp Ala Val Thr Leu Trp Ala Tyr Ala Leu Gly Ala Thr Val Leu
    130                 135                 140                 
Ile Ser Ala Ala Pro Phe Phe Val Leu Phe Leu Ile Pro Val Glu Ser
145                 150                 155                 160 
Asn Ser Pro Arg His Arg Ser Leu Leu Gln Ile Leu Leu Ser Phe Ala
                165                 170                 175     
Ser Gly Gly Leu Leu Gly Asp Ala Phe Leu His Leu Ile Pro His Ala
            180                 185                 190         
Leu Glu Pro His Ser His His Thr Leu Glu Gln Pro Gly His Gly His
        195                 200                 205             
Ser His Ser Gly Gln Gly Pro Ile Leu Ser Val Gly Leu Trp Val Leu
    210                 215                 220                 
Ser Gly Ile Val Ala Phe Leu Val Val Glu Lys Phe Val Arg His Val
225                 230                 235                 240 
Lys Gly Gly His Gly His Ser His Gly His Gly His Ala His Ser His
                245                 250                 255     
Thr Arg Gly Ser His Gly His Gly Arg Gln Glu Arg Ser Thr Lys Glu
            260                 265                 270         
Lys Gln Ser Ser Glu Glu Glu Glu Lys Glu Thr Arg Gly Val Gln Lys
        275                 280                 285             
Arg Arg Gly Gly Ser Thr Val Pro Lys Asp Gly Pro Val Arg Pro Gln
    290                 295                 300                 
Asn Ala Glu Glu Glu Lys Arg Gly Leu Asp Leu Arg Val Ser Gly Tyr
305                 310                 315                 320 
Leu Asn Leu Ala Ala Asp Leu Ala His Asn Phe Thr Asp Gly Leu Ala
                325                 330                 335     
Ile Gly Ala Ser Phe Arg Gly Gly Arg Gly Leu Gly Ile Leu Thr Thr
            340                 345                 350         
Met Thr Val Leu Leu His Glu Val Pro His Glu Val Gly Asp Phe Ala
        355                 360                 365             
Ile Leu Val Gln Ser Gly Cys Ser Lys Lys Gln Ala Met Arg Leu Gln
    370                 375                 380                 
Leu Leu Thr Ala Val Gly Ala Leu Ala Gly Thr Ala Cys Ala Leu Leu
385                 390                 395                 400 
Thr Glu Gly Gly Ala Val Gly Ser Glu Ile Ala Gly Gly Ala Gly Pro
                405                 410                 415     
Gly Trp Val Leu Pro Phe Thr Ala Gly Gly Phe Ile Tyr Val Ala Thr
            420                 425                 430         
Val Ser Val Leu Pro Glu Leu Leu Arg Glu Ala Ser Pro Leu Gln Ser
        435                 440                 445             
Leu Leu Glu Val Leu Gly Leu Leu Gly Gly Val Ile Met Met Val Leu
    450                 455                 460                 
Ile Ala His Leu Glu
465                 


<210> 9172
<211> 428
<212> PRT
<213> Homo sapiens

<400> 9172
Met Ala Arg Gly Leu Gly Ala Pro His Trp Val Ala Val Gly Leu Leu
 1               5                  10                  15      
Thr Trp Ala Thr Leu Gly Leu Leu Val Ala Gly Leu Gly Gly His Asp
            20                  25                  30          
Asp Leu His Asp Asp Leu Gln Glu Asp Phe His Gly His Ser His Arg
        35                  40                  45              
His Ser His Glu Asp Phe His His Gly His Ser His Ala His Gly His
    50                  55                  60                  
Gly His Thr His Glu Ser Ile Trp His Gly His Thr His Asp His Asp
65                  70                  75                  80  
His Gly His Ser His Glu Asp Leu His His Gly His Ser His Gly Tyr
                85                  90                  95      
Ser His Glu Ser Leu Tyr His Arg Gly His Gly His Asp His Glu His
            100                 105                 110         
Ser His Gly Gly Tyr Gly Glu Ser Gly Ala Pro Gly Ile Lys Gln Asp
        115                 120                 125             
Leu Asp Ala Val Thr Leu Trp Ala Tyr Ala Leu Gly Ala Thr Val Leu
    130                 135                 140                 
Ile Ser Ala Ala Pro Phe Phe Val Leu Phe Leu Ile Pro Val Glu Ser
145                 150                 155                 160 
Asn Ser Pro Arg His Arg Ser Leu Leu Gln Ile Leu Leu Ser Phe Ala
                165                 170                 175     
Ser Gly Gly Leu Leu Gly Asp Ala Phe Leu His Leu Ile Pro His Ala
            180                 185                 190         
Leu Glu Pro His Ser His His Thr Leu Glu Gln Pro Gly His Gly His
        195                 200                 205             
Ser His Ser Gly Gln Gly Pro Ile Leu Ser Val Gly Leu Trp Val Leu
    210                 215                 220                 
Ser Gly Ile Val Ala Phe Leu Val Val Glu Lys Phe Val Arg His Val
225                 230                 235                 240 
Lys Gly Gly His Gly His Ser His Gly His Gly His Ala His Ser His
                245                 250                 255     
Thr Arg Gly Ser His Gly His Gly Arg Gln Glu Arg Ser Thr Lys Glu
            260                 265                 270         
Lys Gln Ser Ser Glu Glu Glu Glu Lys Glu Thr Arg Gly Val Gln Lys
        275                 280                 285             
Arg Arg Gly Gly Ser Thr Val Pro Lys Asp Gly Pro Val Arg Pro Gln
    290                 295                 300                 
Asn Ala Glu Glu Glu Lys Arg Gly Leu Asp Leu Arg Val Ser Gly Tyr
305                 310                 315                 320 
Leu Asn Leu Ala Ala Asp Leu Ala His Asn Phe Thr Asp Gly Leu Ala
                325                 330                 335     
Ile Gly Ala Ser Phe Arg Gly Gly Arg Gly Leu Gly Ile Leu Thr Thr
            340                 345                 350         
Met Thr Val Leu Leu His Glu Val Pro His Glu Val Gly Asp Phe Ala
        355                 360                 365             
Ile Leu Val Gln Ser Gly Cys Ser Lys Lys Gln Ala Met Arg Leu Gln
    370                 375                 380                 
Leu Leu Thr Ala Val Gly Ala Leu Ala Gly Thr Val Pro Phe Ser Leu
385                 390                 395                 400 
Lys Glu Glu Gln Trp Ala Val Lys Leu Gln Val Val Gln Val Leu Ala
                405                 410                 415     
Gly Ser Cys His Leu Leu Gln Val Ala Leu Ser Thr
            420                 425             


<210> 9173
<211> 380
<212> PRT
<213> Homo sapiens

<400> 9173
Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln
 1               5                  10                  15      
Ser Glu Cys Glu Tyr Thr Asp Trp Lys Ser Ser Gly Ala Leu Ile Pro
            20                  25                  30          
Ala Ile Tyr Met Leu Val Phe Leu Leu Gly Thr Thr Gly Asn Gly Leu
        35                  40                  45              
Val Leu Trp Thr Val Phe Arg Ser Ser Arg Glu Lys Arg Arg Ser Ala
    50                  55                  60                  
Asp Ile Phe Ile Ala Ser Leu Ala Val Ala Asp Leu Thr Phe Val Val
65                  70                  75                  80  
Thr Leu Pro Leu Trp Ala Thr Tyr Thr Tyr Arg Asp Tyr Asp Trp Pro
                85                  90                  95      
Phe Gly Thr Phe Phe Cys Lys Leu Ser Ser Tyr Leu Ile Phe Val Asn
            100                 105                 110         
Met Tyr Ala Ser Val Phe Cys Leu Thr Gly Leu Ser Phe Asp Arg Tyr
        115                 120                 125             
Leu Ala Ile Val Arg Pro Val Ala Asn Ala Arg Leu Arg Leu Arg Val
    130                 135                 140                 
Ser Gly Ala Val Ala Thr Ala Val Leu Trp Val Leu Ala Ala Leu Leu
145                 150                 155                 160 
Ala Met Pro Val Met Val Leu Arg Thr Thr Gly Asp Leu Glu Asn Thr
                165                 170                 175     
Thr Lys Val Gln Cys Tyr Met Asp Tyr Ser Met Val Ala Thr Val Ser
            180                 185                 190         
Ser Glu Trp Ala Trp Glu Val Gly Leu Gly Val Ser Ser Thr Thr Val
        195                 200                 205             
Gly Phe Val Val Pro Phe Thr Ile Met Leu Thr Cys Tyr Phe Phe Ile
    210                 215                 220                 
Ala Gln Thr Ile Ala Gly His Phe Arg Lys Glu Arg Ile Glu Gly Leu
225                 230                 235                 240 
Arg Lys Arg Arg Arg Leu Leu Ser Ile Ile Val Val Leu Val Val Thr
                245                 250                 255     
Phe Ala Leu Cys Trp Met Pro Tyr His Leu Val Lys Thr Leu Tyr Met
            260                 265                 270         
Leu Gly Ser Leu Leu His Trp Pro Cys Asp Phe Asp Leu Phe Leu Met
        275                 280                 285             
Asn Ile Phe Pro Tyr Cys Thr Cys Ile Ser Tyr Val Asn Ser Cys Leu
    290                 295                 300                 
Asn Pro Phe Leu Tyr Ala Phe Phe Asp Pro Arg Phe Arg Gln Ala Cys
305                 310                 315                 320 
Thr Ser Met Leu Cys Cys Gly Gln Ser Arg Cys Ala Gly Thr Ser His
                325                 330                 335     
Ser Ser Ser Gly Glu Lys Ser Ala Ser Tyr Ser Ser Gly His Ser Gln
            340                 345                 350         
Gly Pro Gly Pro Asn Met Gly Lys Gly Gly Glu Gln Met His Glu Lys
        355                 360                 365             
Ser Ile Pro Tyr Ser Gln Glu Thr Leu Val Val Asp
    370                 375                 380 


<210> 9174
<211> 803
<212> PRT
<213> Homo sapiens

<400> 9174
Met Ile Pro Val Thr Glu Phe Arg Gln Phe Ser Glu Gln Gln Pro Ala
 1               5                  10                  15      
Phe Arg Val Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Leu Ser
            20                  25                  30          
Val Ala Met Leu Met Ile Gly Val Phe Gly Cys Thr Leu Gln Val Met
        35                  40                  45              
Gln Asp Lys Ile Ile Cys Leu Pro Lys Arg Val Gln Pro Ala Gln Asn
    50                  55                  60                  
His Ser Ser Leu Ser Asn Val Ser Gln Ala Val Ala Ser Thr Thr Pro
65                  70                  75                  80  
Leu Pro Pro Pro Lys Pro Ser Pro Ala Asn Pro Ile Thr Val Glu Met
                85                  90                  95      
Lys Gly Leu Lys Thr Asp Leu Asp Leu Gln Gln Tyr Ser Phe Ile Asn
            100                 105                 110         
Gln Met Cys Tyr Glu Arg Ala Leu His Trp Tyr Ala Lys Tyr Phe Pro
        115                 120                 125             
Tyr Leu Val Leu Ile His Thr Leu Val Phe Met Leu Cys Ser Asn Phe
    130                 135                 140                 
Trp Phe Lys Phe Pro Gly Ser Ser Ser Lys Ile Glu His Phe Ile Ser
145                 150                 155                 160 
Ile Leu Gly Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser
                165                 170                 175     
Glu Val Ser Gly Glu Asp Ser Glu Glu Lys Asp Asn Arg Lys Asn Asn
            180                 185                 190         
Met Asn Arg Ser Asn Thr Ile Gln Ser Gly Pro Glu Gly Ser Leu Val
        195                 200                 205             
Asn Ser Gln Ser Leu Lys Ser Ile Pro Glu Lys Phe Val Val Asp Lys
    210                 215                 220                 
Ser Thr Ala Gly Ala Leu Asp Lys Lys Glu Gly Glu Gln Ala Lys Ala
225                 230                 235                 240 
Leu Phe Glu Lys Val Lys Lys Phe Arg Leu His Val Glu Glu Gly Asp
                245                 250                 255     
Ile Leu Tyr Ala Met Tyr Val Arg Gln Thr Val Leu Lys Val Ile Lys
            260                 265                 270         
Phe Leu Ile Ile Ile Ala Tyr Asn Ser Ala Leu Val Ser Lys Val Gln
        275                 280                 285             
Phe Thr Val Asp Cys Asn Val Asp Ile Gln Asp Met Thr Gly Tyr Lys
    290                 295                 300                 
Asn Phe Ser Cys Asn His Thr Met Ala His Leu Phe Ser Lys Leu Ser
305                 310                 315                 320 
Phe Cys Tyr Leu Cys Phe Val Ser Ile Tyr Gly Leu Thr Cys Leu Tyr
                325                 330                 335     
Thr Leu Tyr Trp Leu Phe Tyr Arg Ser Leu Arg Glu Tyr Ser Phe Glu
            340                 345                 350         
Tyr Val Arg Gln Glu Thr Gly Ile Asp Asp Ile Pro Asp Val Lys Asn
        355                 360                 365             
Asp Phe Ala Phe Met Leu His Met Ile Asp Gln Tyr Asp Pro Leu Tyr
    370                 375                 380                 
Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu Asn Lys Leu
385                 390                 395                 400 
Lys Gln Leu Asn Leu Asn Asn Glu Trp Thr Pro Asp Lys Leu Arg Gln
                405                 410                 415     
Lys Leu Gln Thr Asn Ala His Asn Arg Leu Glu Leu Pro Leu Ile Met
            420                 425                 430         
Leu Ser Gly Leu Pro Asp Thr Val Phe Glu Ile Thr Glu Leu Gln Ser
        435                 440                 445             
Leu Lys Leu Glu Ile Ile Lys Asn Val Met Ile Pro Ala Thr Ile Ala
    450                 455                 460                 
Gln Leu Asp Asn Leu Gln Glu Leu Ser Leu His Gln Cys Ser Val Lys
465                 470                 475                 480 
Ile His Ser Ala Ala Leu Ser Phe Leu Lys Glu Asn Leu Lys Val Leu
                485                 490                 495     
Ser Val Lys Phe Asp Asp Met Arg Glu Leu Pro Pro Trp Met Tyr Gly
            500                 505                 510         
Leu Arg Asn Leu Glu Glu Leu Tyr Leu Val Gly Ser Leu Ser His Asp
        515                 520                 525             
Ile Ser Arg Asn Val Thr Leu Glu Ser Leu Arg Asp Leu Lys Ser Leu
    530                 535                 540                 
Lys Ile Leu Ser Ile Lys Ser Asn Val Ser Lys Ile Pro Gln Ala Val
545                 550                 555                 560 
Val Asp Val Ser Ser His Leu Gln Lys Met Cys Ile His Asn Asp Gly
                565                 570                 575     
Thr Lys Leu Val Met Leu Asn Asn Leu Lys Lys Met Thr Asn Leu Thr
            580                 585                 590         
Glu Leu Glu Leu Val His Cys Asp Leu Glu Arg Ile Pro His Ala Val
        595                 600                 605             
Phe Ser Leu Leu Ser Leu Gln Glu Leu Asp Leu Lys Glu Asn Asn Leu
    610                 615                 620                 
Lys Ser Ile Glu Glu Ile Val Ser Phe Gln His Leu Arg Lys Leu Thr
625                 630                 635                 640 
Val Leu Lys Leu Trp His Asn Ser Ile Thr Tyr Ile Pro Glu His Ile
                645                 650                 655     
Lys Lys Leu Thr Ser Leu Glu Arg Leu Ser Phe Ser His Asn Lys Ile
            660                 665                 670         
Glu Val Leu Pro Ser His Leu Phe Leu Cys Asn Lys Ile Arg Tyr Leu
        675                 680                 685             
Asp Leu Ser Tyr Asn Asp Ile Arg Phe Ile Pro Pro Glu Ile Gly Val
    690                 695                 700                 
Leu Gln Ser Leu Gln Tyr Phe Ser Ile Thr Cys Asn Lys Val Glu Ser
705                 710                 715                 720 
Leu Pro Asp Glu Leu Tyr Phe Cys Lys Lys Leu Lys Thr Leu Lys Ile
                725                 730                 735     
Gly Lys Asn Ser Leu Ser Val Leu Ser Pro Lys Ile Gly Asn Leu Leu
            740                 745                 750         
Phe Leu Ser Tyr Leu Asp Val Lys Gly Asn His Phe Glu Ile Leu Pro
        755                 760                 765             
Pro Glu Leu Gly Asp Cys Arg Ala Leu Lys Arg Ala Gly Leu Val Val
    770                 775                 780                 
Glu Asp Ala Leu Phe Glu Thr Leu Pro Ser Asp Val Arg Glu Gln Met
785                 790                 795                 800 
Lys Thr Glu
            


<210> 9175
<211> 704
<212> PRT
<213> Homo sapiens

<400> 9175
Met Ala Phe Leu Ser Arg Thr Ser Pro Val Ala Ala Ala Ser Phe Gln
 1               5                  10                  15      
Ser Arg Gln Glu Ala Arg Gly Ser Ile Leu Leu Gln Ser Cys Gln Leu
            20                  25                  30          
Pro Pro Gln Trp Leu Ser Thr Glu Ala Trp Thr Gly Glu Trp Lys Gln
        35                  40                  45              
Pro His Gly Gly Ala Leu Thr Ser Arg Ser Pro Gly Pro Val Ala Pro
    50                  55                  60                  
Gln Arg Pro Cys His Leu Lys Gly Trp Gln His Arg Pro Thr Gln His
65                  70                  75                  80  
Asn Ala Ala Cys Lys Gln Gly Gln Ala Ala Ala Gln Thr Pro Pro Arg
                85                  90                  95      
Pro Gly Pro Pro Ser Ala Pro Pro Pro Pro Pro Lys Glu Gly His Gln
            100                 105                 110         
Glu Gly Leu Val Glu Leu Pro Ala Ser Phe Arg Glu Leu Leu Thr Phe
        115                 120                 125             
Phe Cys Thr Asn Ala Thr Ile His Gly Ala Ile Arg Leu Val Cys Ser
    130                 135                 140                 
Arg Gly Asn Arg Leu Lys Thr Thr Ser Trp Gly Leu Leu Ser Leu Gly
145                 150                 155                 160 
Ala Leu Val Ala Leu Cys Trp Gln Leu Gly Leu Leu Phe Glu Arg His
                165                 170                 175     
Trp His Arg Pro Val Leu Met Ala Val Ser Val His Ser Glu Arg Lys
            180                 185                 190         
Leu Leu Pro Leu Val Thr Leu Cys Asp Gly Asn Pro Arg Arg Pro Ser
        195                 200                 205             
Pro Val Leu Arg His Leu Glu Leu Leu Asp Glu Phe Ala Arg Glu Asn
    210                 215                 220                 
Ile Asp Ser Leu Tyr Asn Val Asn Leu Ser Lys Gly Arg Ala Ala Leu
225                 230                 235                 240 
Ser Ala Thr Val Pro Arg His Glu Pro Pro Phe His Leu Asp Arg Glu
                245                 250                 255     
Ile Arg Leu Gln Arg Leu Ser His Ser Gly Ser Arg Val Arg Val Gly
            260                 265                 270         
Phe Arg Leu Cys Asn Ser Thr Gly Gly Asp Cys Phe Tyr Arg Gly Tyr
        275                 280                 285             
Thr Ser Gly Val Ala Ala Val Gln Asp Trp Tyr His Phe His Tyr Val
    290                 295                 300                 
Asp Ile Leu Ala Leu Leu Pro Ala Ala Trp Glu Asp Ser His Gly Ser
305                 310                 315                 320 
Gln Asp Gly His Phe Val Leu Ser Cys Ser Tyr Asp Gly Leu Asp Cys
                325                 330                 335     
Gln Ala Arg Gln Phe Arg Thr Phe His His Pro Thr Tyr Gly Ser Cys
            340                 345                 350         
Tyr Thr Val Asp Gly Val Trp Thr Ala Gln Arg Pro Gly Ile Thr His
        355                 360                 365             
Gly Val Gly Leu Val Leu Arg Val Glu Gln Gln Pro His Leu Pro Leu
    370                 375                 380                 
Leu Ser Thr Leu Ala Gly Ile Arg Val Met Val His Gly Arg Asn His
385                 390                 395                 400 
Thr Pro Phe Leu Gly His His Ser Phe Ser Val Arg Pro Gly Thr Glu
                405                 410                 415     
Ala Thr Ile Ser Ile Arg Glu Asp Glu Val His Arg Leu Gly Ser Pro
            420                 425                 430         
Tyr Gly His Cys Thr Ala Gly Gly Glu Gly Val Glu Val Glu Leu Leu
        435                 440                 445             
His Asn Thr Ser Tyr Thr Arg Gln Ala Cys Leu Val Ser Cys Phe Gln
    450                 455                 460                 
Gln Leu Met Val Glu Thr Cys Ser Cys Gly Tyr Tyr Leu His Pro Leu
465                 470                 475                 480 
Pro Ala Gly Ala Glu Tyr Cys Ser Ser Ala Arg His Pro Ala Trp Gly
                485                 490                 495     
His Cys Phe Tyr Arg Leu Tyr Gln Asp Leu Glu Thr His Arg Leu Pro
            500                 505                 510         
Cys Thr Ser Arg Cys Pro Arg Pro Cys Arg Glu Ser Ala Phe Lys Leu
        515                 520                 525             
Ser Thr Gly Thr Ser Arg Trp Pro Ser Ala Lys Ser Ala Gly Trp Thr
    530                 535                 540                 
Leu Ala Thr Leu Gly Glu Gln Gly Leu Pro His Gln Ser His Arg Gln
545                 550                 555                 560 
Arg Ser Ser Leu Ala Lys Ile Asn Ile Val Tyr Gln Glu Leu Asn Tyr
                565                 570                 575     
Arg Ser Val Glu Glu Ala Pro Val Tyr Ser Val Pro Gln Leu Leu Ser
            580                 585                 590         
Ala Met Gly Ser Leu Tyr Ser Leu Trp Phe Gly Ala Ser Val Leu Ser
        595                 600                 605             
Leu Leu Glu Leu Leu Glu Leu Leu Leu Asp Ala Ser Ala Leu Thr Leu
    610                 615                 620                 
Val Leu Gly Gly Arg Arg Leu Arg Arg Ala Trp Phe Ser Trp Pro Arg
625                 630                 635                 640 
Ala Ser Pro Ala Ser Gly Ala Ser Ser Ile Lys Pro Glu Ala Ser Gln
                645                 650                 655     
Met Pro Pro Pro Ala Gly Gly Thr Ser Asp Asp Pro Glu Pro Ser Gly
            660                 665                 670         
Pro His Leu Pro Arg Val Met Leu Pro Gly Val Leu Ala Gly Val Ser
        675                 680                 685             
Ala Glu Glu Ser Trp Ala Gly Pro Gln Pro Leu Glu Thr Leu Asp Thr
    690                 695                 700                 


<210> 9176
<211> 638
<212> PRT
<213> Homo sapiens

<400> 9176
Met Ala Glu His Arg Ser Met Asp Gly Arg Met Glu Ala Ala Thr Arg
 1               5                  10                  15      
Gly Gly Ser His Leu Gln Ala Ala Ala Gln Thr Pro Pro Arg Pro Gly
            20                  25                  30          
Pro Pro Ser Ala Pro Pro Pro Pro Pro Lys Glu Gly His Gln Glu Gly
        35                  40                  45              
Leu Val Glu Leu Pro Ala Ser Phe Arg Glu Leu Leu Thr Phe Phe Cys
    50                  55                  60                  
Thr Asn Ala Thr Ile His Gly Ala Ile Arg Leu Val Cys Ser Arg Gly
65                  70                  75                  80  
Asn Arg Leu Lys Thr Thr Ser Trp Gly Leu Leu Ser Leu Gly Ala Leu
                85                  90                  95      
Val Ala Leu Cys Trp Gln Leu Gly Leu Leu Phe Glu Arg His Trp His
            100                 105                 110         
Arg Pro Val Leu Met Ala Val Ser Val His Ser Glu Arg Lys Leu Leu
        115                 120                 125             
Pro Leu Val Thr Leu Cys Asp Gly Asn Pro Arg Arg Pro Ser Pro Val
    130                 135                 140                 
Leu Arg His Leu Glu Leu Leu Asp Glu Phe Ala Arg Glu Asn Ile Asp
145                 150                 155                 160 
Ser Leu Tyr Asn Val Asn Leu Ser Lys Gly Arg Ala Ala Leu Ser Ala
                165                 170                 175     
Thr Val Pro Arg His Glu Pro Pro Phe His Leu Asp Arg Glu Ile Arg
            180                 185                 190         
Leu Gln Arg Leu Ser His Ser Gly Ser Arg Val Arg Val Gly Phe Arg
        195                 200                 205             
Leu Cys Asn Ser Thr Gly Gly Asp Cys Phe Tyr Arg Gly Tyr Thr Ser
    210                 215                 220                 
Gly Val Ala Ala Val Gln Asp Trp Tyr His Phe His Tyr Val Asp Ile
225                 230                 235                 240 
Leu Ala Leu Leu Pro Ala Ala Trp Glu Asp Ser His Gly Ser Gln Asp
                245                 250                 255     
Gly His Phe Val Leu Ser Cys Ser Tyr Asp Gly Leu Asp Cys Gln Ala
            260                 265                 270         
Arg Gln Phe Arg Thr Phe His His Pro Thr Tyr Gly Ser Cys Tyr Thr
        275                 280                 285             
Val Asp Gly Val Trp Thr Ala Gln Arg Pro Gly Ile Thr His Gly Val
    290                 295                 300                 
Gly Leu Val Leu Arg Val Glu Gln Gln Pro His Leu Pro Leu Leu Ser
305                 310                 315                 320 
Thr Leu Ala Gly Ile Arg Val Met Val His Gly Arg Asn His Thr Pro
                325                 330                 335     
Phe Leu Gly His His Ser Phe Ser Val Arg Pro Gly Thr Glu Ala Thr
            340                 345                 350         
Ile Ser Ile Arg Glu Asp Glu Val His Arg Leu Gly Ser Pro Tyr Gly
        355                 360                 365             
His Cys Thr Ala Gly Gly Glu Gly Val Glu Val Glu Leu Leu His Asn
    370                 375                 380                 
Thr Ser Tyr Thr Arg Gln Ala Cys Leu Val Ser Cys Phe Gln Gln Leu
385                 390                 395                 400 
Met Val Glu Thr Cys Ser Cys Gly Tyr Tyr Leu His Pro Leu Pro Ala
                405                 410                 415     
Gly Ala Glu Tyr Cys Ser Ser Ala Arg His Pro Ala Trp Gly His Cys
            420                 425                 430         
Phe Tyr Arg Leu Tyr Gln Asp Leu Glu Thr His Arg Leu Pro Cys Thr
        435                 440                 445             
Ser Arg Cys Pro Arg Pro Cys Arg Glu Ser Ala Phe Lys Leu Ser Thr
    450                 455                 460                 
Gly Thr Ser Arg Trp Pro Ser Ala Lys Ser Ala Gly Trp Thr Leu Ala
465                 470                 475                 480 
Thr Leu Gly Glu Gln Gly Leu Pro His Gln Ser His Arg Gln Arg Ser
                485                 490                 495     
Ser Leu Ala Lys Ile Asn Ile Val Tyr Gln Glu Leu Asn Tyr Arg Ser
            500                 505                 510         
Val Glu Glu Ala Pro Val Tyr Ser Val Pro Gln Leu Leu Ser Ala Met
        515                 520                 525             
Gly Ser Leu Tyr Ser Leu Trp Phe Gly Ala Ser Val Leu Ser Leu Leu
    530                 535                 540                 
Glu Leu Leu Glu Leu Leu Leu Asp Ala Ser Ala Leu Thr Leu Val Leu
545                 550                 555                 560 
Gly Gly Arg Arg Leu Arg Arg Ala Trp Phe Ser Trp Pro Arg Ala Ser
                565                 570                 575     
Pro Ala Ser Gly Ala Ser Ser Ile Lys Pro Glu Ala Ser Gln Met Pro
            580                 585                 590         
Pro Pro Ala Gly Gly Thr Ser Asp Asp Pro Glu Pro Ser Gly Pro His
        595                 600                 605             
Leu Pro Arg Val Met Leu Pro Gly Val Leu Ala Gly Val Ser Ala Glu
    610                 615                 620                 
Glu Ser Trp Ala Gly Pro Gln Pro Leu Glu Thr Leu Asp Thr
625                 630                 635             


<210> 9177
<211> 315
<212> PRT
<213> Homo sapiens

<400> 9177
Met Phe Ser Pro Asn His Thr Ile Val Thr Glu Phe Ile Leu Leu Gly
 1               5                  10                  15      
Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu
            20                  25                  30          
Ala Ile Tyr Leu Ile Thr Leu Ala Gly Asn Leu Cys Met Ile Leu Leu
        35                  40                  45              
Ile Arg Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Gly
    50                  55                  60                  
His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Val Thr Pro Asn
65                  70                  75                  80  
Met Leu His Asn Phe Leu Ser Glu Gln Lys Thr Ile Ser Tyr Ala Gly
                85                  90                  95      
Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe
            100                 105                 110         
Tyr Ile Leu Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser
        115                 120                 125             
Pro Leu His Tyr Ser Ser Arg Met Ser Lys Asn Ile Cys Val Cys Leu
    130                 135                 140                 
Val Thr Ile Pro Tyr Met Tyr Gly Phe Leu Ser Gly Phe Ser Gln Ser
145                 150                 155                 160 
Leu Leu Thr Phe His Leu Ser Phe Cys Gly Ser Leu Glu Ile Asn His
                165                 170                 175     
Phe Tyr Cys Ala Asp Pro Pro Leu Ile Met Leu Ala Cys Ser Asp Thr
            180                 185                 190         
Arg Val Lys Lys Met Ala Met Phe Val Val Ala Gly Phe Asn Leu Ser
        195                 200                 205             
Ser Ser Leu Phe Ile Ile Leu Leu Ser Tyr Leu Phe Ile Phe Ala Ala
    210                 215                 220                 
Ile Phe Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr
225                 230                 235                 240 
Cys Ala Ser His Leu Thr Ile Val Thr Leu Phe Tyr Gly Thr Leu Phe
                245                 250                 255     
Cys Met Tyr Val Arg Pro Pro Ser Glu Lys Ser Val Glu Glu Ser Lys
            260                 265                 270         
Ile Thr Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu
        275                 280                 285             
Ile Tyr Ser Leu Arg Asn Thr Asp Val Ile Leu Ala Met Gln Gln Met
    290                 295                 300                 
Ile Arg Gly Lys Ser Phe His Lys Ile Ala Val
305                 310                 315 


<210> 9178
<211> 745
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 231, 554
<223> Xaa = Any Amino Acid

<400> 9178
Met Gly Leu Gly Pro Ala Trp Val Thr Gln Pro Cys Leu Val Thr Asp
 1               5                  10                  15      
Ser Gln Pro Asp Ala Glu Leu Leu Ser Ser Arg Ala Pro Cys Leu Gly
            20                  25                  30          
Arg Arg Cys Cys Trp Ser Pro Gly Arg Gly Gly Val Gly Gly Ser Gly
        35                  40                  45              
Thr Thr Glu Pro Gly Asp Ala Ala Leu Pro Cys Pro Gly Arg Val Ala
    50                  55                  60                  
Gln Ala Pro Pro Arg Arg Leu Leu Leu Leu Leu Pro Leu Leu Leu Gly
65                  70                  75                  80  
Arg Gly Leu Arg Val Thr Ala Glu Ala Ser Ala Ser Ser Ser Gly Ala
                85                  90                  95      
Ala Val Glu Asn Ser Ser Ala Met Glu Glu Leu Val Thr Glu Lys Glu
            100                 105                 110         
Ala Glu Glu Ser His Arg Pro Asp Ser Val Ser Leu Leu Thr Phe Ile
        115                 120                 125             
Leu Leu Leu Thr Leu Ala Ile Leu Thr Ile Trp Leu Phe Lys Tyr Cys
    130                 135                 140                 
Arg Val His Phe Leu His Glu Thr Gly Leu Ala Met Ile Cys Gly Leu
145                 150                 155                 160 
Ile Val Gly Val Ile Leu Arg Tyr Gly Thr Pro Gly Thr Arg Gly Arg
                165                 170                 175     
Asp Lys Leu Leu Asn Cys Thr Gln Glu Asp Gln Ala Phe Ser Thr Leu
            180                 185                 190         
Val Val Asp Val Ser Gly Lys Phe Phe Glu Tyr Thr Leu Lys Arg Glu
        195                 200                 205             
Ile Ser Pro Gly Lys Ile Asn Ser Val Lys Gln Asn Asp Met Leu Gly
    210                 215                 220                 
Lys Val Thr Phe Asp Pro Xaa Val Phe Phe Asn Ile Leu Leu Pro Pro
225                 230                 235                 240 
Val Ile Phe His Ala Gly Tyr Ser Leu Lys Arg His Phe Phe Arg Asn
                245                 250                 255     
Leu Gly Ser Leu Leu Leu Gly Asp Cys Cys Phe Val Leu Pro Tyr Trp
            260                 265                 270         
Lys Ser Gln Ser Val Gly Ile Phe Leu Gly Ile Phe Ser Gly Cys Phe
        275                 280                 285             
Thr Met Gly Ala Val Thr Gly Val Val Thr Ala Leu Val Thr Lys Phe
    290                 295                 300                 
Thr Lys Leu Asp Cys Phe Pro Leu Leu Glu Thr Ala Leu Phe Phe Leu
305                 310                 315                 320 
Met Ser Trp Ser Thr Phe Leu Leu Ala Glu Ala Cys Gly Phe Thr Gly
                325                 330                 335     
Val Val Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Phe
            340                 345                 350         
Asn Asn Leu Ser Val Glu Ser Arg Ser Arg Ser Lys Gln Leu Phe Glu
        355                 360                 365             
Ala Glu Asn Phe Ile Phe Ser Cys Met Ile Leu Ala Leu Phe Thr Phe
    370                 375                 380                 
Gln Lys His Val Phe Ser Pro Val Phe Ile Ile Gly Ala Phe Val Ala
385                 390                 395                 400 
Val Phe Leu Gly Arg Ala Ala His Ile Tyr Pro Leu Ser Phe Phe Leu
                405                 410                 415     
Ser Leu Gly Arg Arg His Lys Ile Gly Trp Asn Phe Gln His Thr Met
            420                 425                 430         
Met Phe Ser Gly Leu Arg Gly Ala Met Ala Phe Ala Leu Ala Ile Cys
        435                 440                 445             
Asp Thr Ala Ser Tyr Ala Arg Gln Met Thr Phe Pro Thr Thr Pro Phe
    450                 455                 460                 
Ile Val Phe Phe Thr Ile Trp Ile Ile Gly Gly Gly Thr Thr Pro Met
465                 470                 475                 480 
Leu Ser Trp Leu Asn Ile Arg Val Ser Ile Lys Glu Pro Ser Lys Glu
                485                 490                 495     
Asp His Asn Glu His His Arg Gln Tyr Phe Arg Val Gly Val Asp Pro
            500                 505                 510         
Asp Gln Asp Pro Pro Pro Asn Asn Asp Ser Phe Gln Val Leu Gln Gly
        515                 520                 525             
Asp Ser Pro Asp Ser Ala Arg Gly Asn Trp Thr Lys Gln Glu Ser Thr
    530                 535                 540                 
Trp Ile Phe Arg Arg Cys Leu Leu Ala Xaa Cys Leu Thr Ser Pro Gln
545                 550                 555                 560 
Val Tyr Asp Asn Gln Glu Pro Leu Arg Glu Gly Asn Ser Asp Phe Ile
                565                 570                 575     
Leu Thr Glu Gly Asp Leu Thr Leu Thr Tyr Gly Asp Ser Thr Val Thr
            580                 585                 590         
Ala Asn Gly Phe Ser Gly Ser His Thr Ala Ser Thr Ser Leu Glu Gly
        595                 600                 605             
Ser Trp Arg Met Lys Ser Ser Ser Glu Glu Val Leu Glu Gln Asp Val
    610                 615                 620                 
Gly Met Gly Asn Gln Lys Val Ser Ser Gln Ala Ser Pro Thr Leu Gln
625                 630                 635                 640 
Lys Pro Pro Val Gln Gln Thr Ser Asn Gly Pro Ser Gln Leu Leu Gln
                645                 650                 655     
His Ile Ala Ser Arg Thr Ser Trp Leu Met Ser Glu Arg Ser Arg Ala
            660                 665                 670         
Gln Thr Glu Pro Gln Ala Thr Ala Ser Gly Lys Lys Arg Gly Gln Gly
        675                 680                 685             
Ala Arg Glu Glu Met Ser Ser Lys Glu Ile Val Pro Ile Thr Ala Pro
    690                 695                 700                 
Val Ser Val Gln Gln Gln Ile Lys Leu Ile Arg Lys Pro Lys Gln Ser
705                 710                 715                 720 
Ala Glu Asn Arg Thr Gln Leu Ser Lys Lys Leu Ser Tyr Thr Val Ala
                725                 730                 735     
Met Thr Phe Asn Gln Ser Ser Asn Arg
            740                 745 


<210> 9179
<211> 696
<212> PRT
<213> Homo sapiens

<400> 9179
Met Lys Phe Ala Glu His Leu Ser Ala His Ile Thr Pro Glu Trp Arg
 1               5                  10                  15      
Lys Gln Tyr Ile Gln Tyr Glu Ala Phe Lys Asp Met Leu Tyr Ser Ala
            20                  25                  30          
Gln Asp Gln Ala Pro Ser Val Glu Val Thr Asp Glu Asp Thr Val Lys
        35                  40                  45              
Arg Tyr Phe Ala Lys Phe Glu Glu Lys Phe Phe Gln Thr Cys Glu Lys
    50                  55                  60                  
Glu Leu Ala Lys Ile Asn Thr Phe Tyr Ser Glu Lys Leu Ala Glu Ala
65                  70                  75                  80  
Gln Arg Arg Phe Ala Thr Leu Gln Asn Glu Leu Gln Ser Ser Leu Asp
                85                  90                  95      
Ala Gln Lys Glu Ser Thr Gly Val Thr Thr Leu Arg Gln Arg Arg Lys
            100                 105                 110         
Pro Val Phe His Leu Ser His Glu Glu Arg Val Gln His Arg Asn Ile
        115                 120                 125             
Lys Asp Leu Lys Leu Ala Phe Ser Glu Phe Tyr Leu Ser Leu Ile Leu
    130                 135                 140                 
Leu Gln Asn Tyr Gln Asn Leu Asn Phe Thr Gly Phe Arg Lys Ile Leu
145                 150                 155                 160 
Lys Lys His Asp Lys Ile Leu Glu Thr Ser Arg Gly Ala Asp Trp Arg
                165                 170                 175     
Val Ala His Val Glu Val Ala Pro Phe Tyr Thr Cys Lys Lys Ile Asn
            180                 185                 190         
Gln Leu Ile Ser Glu Thr Glu Ala Val Val Thr Asn Glu Leu Glu Asp
        195                 200                 205             
Gly Asp Arg Gln Lys Ala Met Lys Arg Leu Arg Val Pro Pro Leu Gly
    210                 215                 220                 
Ala Ala Gln Pro Ala Pro Ala Trp Thr Thr Phe Arg Val Gly Leu Phe
225                 230                 235                 240 
Cys Gly Ile Phe Ile Val Leu Asn Ile Thr Leu Val Leu Ala Ala Val
                245                 250                 255     
Phe Lys Leu Glu Thr Asp Arg Ser Ile Trp Pro Leu Ile Arg Ile Tyr
            260                 265                 270         
Arg Gly Gly Phe Leu Leu Ile Glu Phe Leu Phe Leu Leu Gly Ile Asn
        275                 280                 285             
Thr Tyr Gly Trp Arg Gln Ala Gly Val Asn His Val Leu Ile Phe Glu
    290                 295                 300                 
Leu Asn Pro Arg Ser Asn Leu Ser His Gln His Leu Phe Glu Ile Ala
305                 310                 315                 320 
Gly Phe Leu Gly Ile Leu Trp Cys Leu Ser Leu Leu Ala Cys Phe Phe
                325                 330                 335     
Ala Pro Ile Ser Val Ile Pro Thr Tyr Val Tyr Pro Leu Ala Leu Tyr
            340                 345                 350         
Gly Phe Met Val Phe Phe Leu Ile Asn Pro Thr Lys Thr Phe Tyr Tyr
        355                 360                 365             
Lys Ser Arg Phe Trp Leu Leu Lys Leu Leu Phe Arg Val Phe Thr Ala
    370                 375                 380                 
Pro Phe His Lys Val Gly Phe Ala Asp Phe Trp Leu Ala Asp Gln Leu
385                 390                 395                 400 
Asn Ser Leu Ser Val Ile Leu Met Asp Leu Glu Tyr Met Ile Cys Phe
                405                 410                 415     
Tyr Ser Leu Glu Leu Lys Trp Asp Glu Ser Lys Gly Leu Leu Pro Asn
            420                 425                 430         
Asn Ser Glu Glu Ser Gly Ile Cys His Lys Tyr Thr Tyr Gly Val Arg
        435                 440                 445             
Ala Ile Val Gln Cys Ile Pro Ala Trp Leu Arg Phe Ile Gln Cys Leu
    450                 455                 460                 
Arg Arg Tyr Arg Asp Thr Lys Arg Ala Phe Pro His Leu Val Asn Ala
465                 470                 475                 480 
Gly Lys Tyr Ser Thr Thr Phe Phe Met Val Ala Phe Ala Ala Leu Tyr
                485                 490                 495     
Ser Thr His Lys Glu Arg Gly His Ser Asp Thr Met Val Phe Phe Tyr
            500                 505                 510         
Leu Trp Ile Val Phe Tyr Ile Ile Ser Ser Cys Tyr Thr Leu Ile Trp
        515                 520                 525             
Asp Leu Lys Met Asp Trp Gly Leu Phe Asp Lys Asn Ala Gly Glu Asn
    530                 535                 540                 
Thr Phe Leu Arg Glu Glu Ile Val Tyr Pro Gln Lys Ala Tyr Tyr Tyr
545                 550                 555                 560 
Cys Ala Ile Ile Glu Asp Val Ile Leu Arg Phe Ala Trp Thr Ile Gln
                565                 570                 575     
Ile Ser Ile Thr Ser Thr Thr Leu Leu Pro His Ser Gly Asp Ile Ile
            580                 585                 590         
Ala Thr Val Phe Ala Pro Leu Glu Val Phe Arg Arg Phe Val Trp Asn
        595                 600                 605             
Phe Phe Arg Leu Glu Asn Glu His Leu Asn Asn Cys Gly Glu Phe Arg
    610                 615                 620                 
Ala Val Arg Asp Ile Ser Val Ala Pro Leu Asn Ala Asp Asp Gln Thr
625                 630                 635                 640 
Leu Leu Glu Gln Met Met Asp Gln Asp Asp Gly Val Arg Asn Arg Gln
                645                 650                 655     
Lys Asn Arg Ser Trp Lys Tyr Asn Gln Ser Ile Ser Leu Arg Arg Pro
            660                 665                 670         
Arg Leu Ala Ser Gln Ser Lys Ala Arg Asp Thr Lys Val Leu Ile Glu
        675                 680                 685             
Asp Thr Asp Asp Glu Ala Asn Thr
    690                 695     


<210> 9180
<211> 696
<212> PRT
<213> Homo sapiens

<400> 9180
Met Lys Phe Ala Glu His Leu Ser Ala His Ile Thr Pro Glu Trp Arg
 1               5                  10                  15      
Lys Gln Tyr Ile Gln Tyr Glu Ala Phe Lys Asp Met Leu Tyr Ser Ala
            20                  25                  30          
Gln Asp Gln Ala Pro Ser Val Glu Val Thr Asp Glu Asp Thr Val Lys
        35                  40                  45              
Arg Tyr Phe Ala Lys Phe Glu Glu Lys Phe Phe Gln Thr Cys Glu Lys
    50                  55                  60                  
Glu Leu Ala Lys Ile Asn Thr Phe Tyr Ser Glu Lys Leu Ala Glu Ala
65                  70                  75                  80  
Gln Arg Arg Phe Ala Thr Leu Gln Asn Glu Leu Gln Ser Ser Leu Asp
                85                  90                  95      
Ala Gln Lys Glu Ser Thr Gly Val Thr Thr Leu Arg Gln Arg Arg Lys
            100                 105                 110         
Pro Val Phe His Leu Ser His Glu Glu Arg Val Gln His Arg Asn Ile
        115                 120                 125             
Lys Asp Leu Lys Leu Ala Phe Ser Glu Phe Tyr Leu Ser Leu Ile Leu
    130                 135                 140                 
Leu Gln Asn Tyr Gln Asn Leu Asn Phe Thr Gly Phe Arg Lys Ile Leu
145                 150                 155                 160 
Lys Lys His Asp Lys Ile Leu Glu Thr Ser Arg Gly Ala Asp Trp Arg
                165                 170                 175     
Val Ala His Val Glu Val Ala Pro Phe Tyr Thr Cys Lys Lys Ile Asn
            180                 185                 190         
Gln Leu Ile Ser Glu Thr Glu Ala Val Val Thr Asn Glu Leu Glu Asp
        195                 200                 205             
Gly Asp Arg Gln Lys Ala Met Lys Arg Leu Arg Val Pro Pro Leu Gly
    210                 215                 220                 
Ala Ala Gln Pro Ala Pro Ala Trp Thr Thr Phe Arg Val Gly Leu Phe
225                 230                 235                 240 
Cys Gly Ile Phe Ile Val Leu Asn Ile Thr Leu Val Leu Ala Ala Val
                245                 250                 255     
Phe Lys Leu Glu Thr Asp Arg Ser Ile Trp Pro Leu Ile Arg Ile Tyr
            260                 265                 270         
Arg Gly Gly Phe Leu Leu Ile Glu Phe Leu Phe Leu Leu Gly Ile Asn
        275                 280                 285             
Thr Tyr Gly Trp Arg Gln Ala Gly Val Asn His Val Leu Ile Phe Glu
    290                 295                 300                 
Leu Asn Pro Arg Ser Asn Leu Ser His Gln His Leu Phe Glu Ile Ala
305                 310                 315                 320 
Gly Phe Leu Gly Ile Leu Trp Cys Leu Ser Leu Leu Ala Cys Phe Phe
                325                 330                 335     
Ala Pro Ile Ser Val Ile Pro Thr Tyr Val Tyr Pro Leu Ala Leu Tyr
            340                 345                 350         
Gly Phe Met Val Phe Phe Leu Ile Asn Pro Thr Lys Thr Phe Tyr Tyr
        355                 360                 365             
Lys Ser Arg Phe Trp Leu Leu Lys Leu Leu Phe Arg Val Phe Thr Ala
    370                 375                 380                 
Pro Phe His Lys Val Gly Phe Ala Asp Phe Trp Leu Ala Asp Gln Leu
385                 390                 395                 400 
Asn Ser Leu Ser Val Ile Leu Met Asp Leu Glu Tyr Met Ile Cys Phe
                405                 410                 415     
Tyr Ser Leu Glu Leu Lys Trp Asp Glu Ser Lys Gly Leu Leu Pro Asn
            420                 425                 430         
Asn Ser Glu Glu Ser Gly Ile Cys His Lys Tyr Thr Tyr Gly Val Arg
        435                 440                 445             
Ala Ile Val Gln Cys Ile Pro Ala Trp Leu Arg Phe Ile Gln Cys Leu
    450                 455                 460                 
Arg Arg Tyr Arg Asp Thr Lys Arg Ala Phe Pro His Leu Val Asn Ala
465                 470                 475                 480 
Gly Lys Tyr Ser Thr Thr Phe Phe Met Val Thr Phe Ala Ala Leu Tyr
                485                 490                 495     
Ser Thr His Lys Glu Arg Gly His Ser Asp Thr Met Val Phe Phe Tyr
            500                 505                 510         
Leu Trp Ile Val Phe Tyr Ile Ile Ser Ser Cys Tyr Thr Leu Ile Trp
        515                 520                 525             
Asp Leu Lys Met Asp Trp Gly Leu Phe Asp Lys Asn Ala Gly Glu Asn
    530                 535                 540                 
Thr Phe Leu Arg Glu Glu Ile Val Tyr Pro Gln Lys Ala Tyr Tyr Tyr
545                 550                 555                 560 
Cys Ala Ile Ile Glu Asp Val Ile Leu Arg Phe Ala Trp Thr Ile Gln
                565                 570                 575     
Ile Ser Ile Thr Ser Thr Thr Leu Leu Pro His Ser Gly Asp Ile Ile
            580                 585                 590         
Ala Thr Val Phe Ala Pro Leu Glu Val Phe Arg Arg Phe Val Trp Asn
        595                 600                 605             
Phe Phe Arg Leu Glu Asn Glu His Leu Asn Asn Cys Gly Glu Phe Arg
    610                 615                 620                 
Ala Val Arg Asp Ile Ser Val Ala Pro Leu Asn Ala Asp Asp Gln Thr
625                 630                 635                 640 
Leu Leu Glu Gln Met Met Asp Gln Asp Asp Gly Val Arg Asn Arg Gln
                645                 650                 655     
Lys Asn Arg Ser Trp Lys Tyr Asn Gln Ser Ile Ser Leu Arg Arg Pro
            660                 665                 670         
Arg Leu Ala Ser Gln Ser Lys Ala Arg Asp Thr Lys Val Leu Ile Glu
        675                 680                 685             
Asp Thr Asp Asp Glu Ala Asn Thr
    690                 695     


<210> 9181
<211> 631
<212> PRT
<213> Homo sapiens

<400> 9181
Met Lys Phe Ala Glu His Leu Ser Ala His Ile Thr Pro Glu Trp Arg
 1               5                  10                  15      
Lys Gln Tyr Ile Gln Tyr Glu Ala Phe Lys Asp Met Leu Tyr Ser Ala
            20                  25                  30          
Gln Asp Gln Ala Pro Ser Val Glu Val Thr Asp Glu Asp Thr Val Lys
        35                  40                  45              
Arg Tyr Phe Ala Lys Phe Glu Glu Lys Phe Phe Gln Thr Cys Glu Lys
    50                  55                  60                  
Glu Leu Ala Lys Ile Asn Thr Phe Tyr Ser Glu Lys Leu Ala Glu Ala
65                  70                  75                  80  
Gln Arg Arg Phe Ala Thr Leu Gln Asn Glu Leu Gln Ser Ser Leu Asp
                85                  90                  95      
Ala Gln Lys Glu Ser Thr Gly Val Thr Thr Leu Arg Gln Arg Arg Lys
            100                 105                 110         
Pro Val Phe His Leu Ser His Glu Glu Arg Val Gln His Arg Asn Ile
        115                 120                 125             
Lys Asp Leu Lys Leu Ala Phe Ser Glu Phe Tyr Leu Ser Leu Ile Leu
    130                 135                 140                 
Leu Gln Asn Tyr Gln Asn Leu Asn Phe Thr Gly Phe Arg Lys Ile Leu
145                 150                 155                 160 
Lys Lys His Asp Lys Ile Leu Glu Thr Ser Arg Gly Ala Asp Trp Arg
                165                 170                 175     
Val Ala His Val Glu Val Ala Pro Phe Tyr Thr Cys Lys Lys Ile Asn
            180                 185                 190         
Gln Leu Ile Ser Glu Thr Glu Ala Val Val Thr Asn Glu Leu Glu Asp
        195                 200                 205             
Gly Asp Arg Gln Lys Ala Met Lys Arg Leu Arg Val Pro Pro Leu Gly
    210                 215                 220                 
Ala Ala Gln Pro Ala Pro Ala Trp Thr Thr Phe Arg Val Gly Leu Phe
225                 230                 235                 240 
Cys Gly Ile Phe Ile Val Leu Asn Ile Thr Leu Val Leu Ala Ala Val
                245                 250                 255     
Phe Lys Leu Glu Thr Asp Arg Ser Ile Trp Pro Leu Ile Arg Ile Tyr
            260                 265                 270         
Arg Gly Gly Phe Leu Leu Ile Glu Phe Leu Phe Leu Leu Gly Ile Asn
        275                 280                 285             
Thr Tyr Gly Trp Arg Gln Ala Gly Val Asn His Val Leu Ile Phe Glu
    290                 295                 300                 
Leu Asn Pro Arg Ser Asn Leu Ser His Gln His Leu Phe Glu Ile Ala
305                 310                 315                 320 
Gly Phe Leu Gly Ile Leu Trp Cys Leu Ser Leu Leu Ala Cys Phe Phe
                325                 330                 335     
Ala Pro Ile Ser Val Ile Pro Thr Tyr Val Tyr Pro Leu Ala Leu Tyr
            340                 345                 350         
Gly Phe Met Val Phe Phe Leu Ile Asn Pro Thr Lys Thr Phe Tyr Tyr
        355                 360                 365             
Lys Ser Arg Phe Trp Leu Leu Lys Leu Leu Phe Arg Val Phe Thr Ala
    370                 375                 380                 
Pro Phe His Lys Val Gly Phe Ala Asp Phe Trp Leu Ala Asp Gln Leu
385                 390                 395                 400 
Asn Ser Leu Ser Val Ile Leu Met Asp Leu Glu Tyr Met Ile Cys Phe
                405                 410                 415     
Tyr Ser Leu Glu Leu Lys Trp Asp Glu Ser Lys Gly Leu Leu Pro Asn
            420                 425                 430         
Asn Ser Glu Glu Arg Gly His Ser Asp Thr Met Val Phe Phe Tyr Leu
        435                 440                 445             
Trp Ile Val Phe Tyr Ile Ile Ser Ser Cys Tyr Thr Leu Ile Trp Asp
    450                 455                 460                 
Leu Lys Met Asp Trp Gly Leu Phe Asp Lys Asn Ala Gly Glu Asn Thr
465                 470                 475                 480 
Phe Leu Arg Glu Glu Ile Val Tyr Pro Gln Lys Ala Tyr Tyr Tyr Cys
                485                 490                 495     
Ala Ile Ile Glu Asp Val Ile Leu Arg Phe Ala Trp Thr Ile Gln Ile
            500                 505                 510         
Ser Ile Thr Ser Thr Thr Leu Leu Pro His Ser Gly Asp Ile Ile Ala
        515                 520                 525             
Thr Val Phe Ala Pro Leu Glu Val Phe Arg Arg Phe Val Trp Asn Phe
    530                 535                 540                 
Phe Arg Leu Glu Asn Glu His Leu Asn Asn Cys Gly Glu Phe Arg Ala
545                 550                 555                 560 
Val Arg Asp Ile Ser Val Ala Pro Leu Asn Ala Asp Asp Gln Thr Leu
                565                 570                 575     
Leu Glu Gln Met Met Asp Gln Asp Asp Gly Val Arg Asn Arg Gln Lys
            580                 585                 590         
Asn Arg Ser Trp Lys Tyr Asn Gln Ser Ile Ser Leu Arg Arg Pro Arg
        595                 600                 605             
Leu Ala Ser Gln Ser Lys Ala Arg Asp Thr Lys Val Leu Ile Glu Asp
    610                 615                 620                 
Thr Asp Asp Glu Ala Asn Thr
625                 630     


<210> 9182
<211> 400
<212> PRT
<213> Homo sapiens

<400> 9182
Pro Gly Val Ala Ala Glu Trp Ala Leu Ser Phe Arg Val Val Met Ala
 1               5                  10                  15      
Gly Tyr Glu Tyr Val Ser Pro Glu Gln Leu Ala Gly Phe Asp Lys Tyr
            20                  25                  30          
Lys Tyr Ser Ala Val Asp Thr Asn Pro Leu Ser Leu Tyr Val Met His
        35                  40                  45              
Pro Phe Trp Asn Thr Ile Val Lys Val Phe Pro Thr Trp Leu Ala Pro
    50                  55                  60                  
Asn Leu Ile Thr Phe Ser Gly Phe Leu Leu Val Val Phe Asn Phe Leu
65                  70                  75                  80  
Leu Met Ala Tyr Phe Asp Pro Asp Phe Tyr Ala Ser Ala Pro Gly His
                85                  90                  95      
Lys His Val Pro Asp Trp Val Trp Ile Val Val Gly Ile Leu Asn Phe
            100                 105                 110         
Val Ala Tyr Thr Leu Asp Gly Val Asp Gly Lys Gln Ala Arg Arg Thr
        115                 120                 125             
Asn Ser Ser Thr Pro Leu Gly Glu Leu Phe Asp His Gly Leu Asp Ser
    130                 135                 140                 
Trp Ser Cys Val Tyr Phe Val Val Thr Val Tyr Ser Ile Phe Gly Arg
145                 150                 155                 160 
Gly Ser Thr Gly Val Ser Val Phe Val Leu Tyr Leu Leu Leu Trp Val
                165                 170                 175     
Val Leu Phe Ser Phe Ile Leu Ser His Trp Glu Lys Tyr Asn Thr Gly
            180                 185                 190         
Ile Leu Phe Leu Pro Trp Gly Tyr Asp Ile Ser Gln Val Thr Ile Ser
        195                 200                 205             
Phe Val Tyr Ile Val Thr Ala Val Val Gly Val Glu Ala Trp Tyr Glu
    210                 215                 220                 
Pro Phe Leu Phe Asn Phe Leu Tyr Arg Asp Leu Phe Thr Ala Met Ile
225                 230                 235                 240 
Ile Gly Cys Ala Leu Cys Val Thr Leu Pro Met Ser Leu Leu Asn Phe
                245                 250                 255     
Phe Arg Ser Tyr Lys Asn Asn Thr Leu Lys Leu Asn Ser Val Tyr Glu
            260                 265                 270         
Ala Met Val Pro Leu Phe Ser Pro Cys Leu Leu Phe Ile Leu Ser Thr
        275                 280                 285             
Ala Trp Ile Leu Trp Ser Pro Ser Asp Ile Leu Glu Leu His Pro Arg
    290                 295                 300                 
Val Phe Tyr Phe Met Val Gly Thr Ala Phe Ala Asn Ser Thr Cys Gln
305                 310                 315                 320 
Leu Ile Val Cys Gln Met Ser Ser Thr Arg Cys Pro Thr Leu Asn Trp
                325                 330                 335     
Leu Leu Val Pro Leu Phe Leu Val Val Leu Val Val Asn Leu Gly Val
            340                 345                 350         
Ala Ser Tyr Val Glu Ser Ile Leu Leu Tyr Thr Leu Thr Thr Ala Phe
        355                 360                 365             
Thr Leu Ala His Ile His Tyr Gly Val Arg Val Val Lys Gln Leu Ser
    370                 375                 380                 
Ser His Phe Gln Ile Tyr Pro Phe Ser Leu Arg Lys Pro Asn Ser Asp
385                 390                 395                 400 


<210> 9183
<211> 363
<212> PRT
<213> Homo sapiens

<400> 9183
Met Gly Pro Gly Glu Ala Leu Leu Ala Gly Leu Leu Val Met Val Leu
 1               5                  10                  15      
Ala Val Ala Leu Leu Ser Asn Ala Leu Val Leu Leu Cys Cys Ala Tyr
            20                  25                  30          
Ser Ala Glu Leu Arg Thr Arg Ala Ser Gly Val Leu Leu Val Asn Leu
        35                  40                  45              
Ser Leu Gly His Leu Leu Leu Ala Ala Leu Asp Met Pro Phe Thr Leu
    50                  55                  60                  
Leu Gly Val Met Arg Gly Arg Thr Pro Ser Ala Pro Gly Ala Cys Gln
65                  70                  75                  80  
Val Ile Gly Phe Leu Asp Thr Phe Leu Ala Ser Asn Ala Ala Leu Ser
                85                  90                  95      
Val Ala Ala Leu Ser Ala Asp Gln Trp Leu Ala Val Gly Phe Pro Leu
            100                 105                 110         
Arg Tyr Ala Gly Arg Leu Arg Pro Arg Tyr Ala Gly Leu Leu Leu Gly
        115                 120                 125             
Cys Ala Trp Gly Gln Ser Leu Ala Phe Ser Gly Ala Ala Leu Gly Cys
    130                 135                 140                 
Ser Trp Leu Gly Tyr Ser Ser Ala Phe Ala Ser Cys Ser Leu Arg Leu
145                 150                 155                 160 
Pro Pro Glu Pro Glu Arg Pro Arg Phe Ala Ala Phe Thr Ala Thr Leu
                165                 170                 175     
His Ala Val Gly Phe Val Leu Pro Leu Ala Val Leu Cys Leu Thr Ser
            180                 185                 190         
Leu Gln Val His Arg Val Ala Arg Arg His Cys Gln Arg Met Asp Thr
        195                 200                 205             
Val Thr Met Lys Ala Leu Ala Val Leu Ala Asp Leu His Pro Ser Val
    210                 215                 220                 
Arg His Gly Cys Leu Ile Gln Gln Lys Arg Arg Arg His Arg Ala Thr
225                 230                 235                 240 
Arg Lys Ile Gly Ile Ala Ile Ala Thr Phe Leu Ile Cys Phe Ala Pro
                245                 250                 255     
Tyr Val Met Thr Arg Leu Ala Glu Leu Val Pro Phe Val Thr Val Asn
            260                 265                 270         
Ala Gln Trp Gly Ile Leu Ser Lys Cys Leu Thr Tyr Ser Lys Ala Val
        275                 280                 285             
Ala Asp Pro Phe Thr Tyr Ser Leu Leu Arg Arg Pro Phe Arg Gln Val
    290                 295                 300                 
Leu Ala Gly Met Val His Arg Leu Leu Lys Arg Thr Pro Arg Pro Ala
305                 310                 315                 320 
Ser Thr His Asp Ser Ser Leu Asp Val Ala Gly Met Val His Gln Leu
                325                 330                 335     
Leu Lys Arg Thr Pro Arg Pro Ala Ser Thr His Asn Gly Ser Val Asp
            340                 345                 350         
Thr Glu Asn Asp Ser Cys Leu Gln Gln Thr His
        355                 360             


<210> 9184
<211> 5058
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 283, 2674
<223> Xaa = Any Amino Acid

<400> 9184
Met Gly His Ala Gly Cys Gln Phe Lys Ala Leu Leu Trp Lys Asn Trp
 1               5                  10                  15      
Leu Cys Arg Leu Arg Asn Pro Val Leu Phe Leu Ala Glu Phe Phe Trp
            20                  25                  30          
Pro Cys Ile Leu Phe Val Ile Leu Thr Val Leu Arg Phe Gln Glu Pro
        35                  40                  45              
Pro Arg Tyr Arg Asp Ile Cys Tyr Leu Gln Pro Arg Asp Leu Pro Ser
    50                  55                  60                  
Cys Gly Val Ile Pro Phe Val Gln Ser Leu Leu Cys Asn Thr Gly Ser
65                  70                  75                  80  
Arg Cys Arg Asn Phe Ser Tyr Glu Gly Ser Met Glu His His Phe Arg
                85                  90                  95      
Leu Ser Arg Phe Gln Thr Ala Ala Asp Pro Lys Lys Val Asn Asn Leu
            100                 105                 110         
Ala Phe Leu Lys Glu Ile Gln Asp Leu Ala Glu Glu Ile His Gly Met
        115                 120                 125             
Met Asp Lys Ala Lys Asn Leu Lys Arg Leu Trp Val Glu Arg Ser Asn
    130                 135                 140                 
Thr Pro Asp Ser Ser Tyr Gly Ser Ser Phe Phe Thr Met Asp Leu Asn
145                 150                 155                 160 
Lys Thr Glu Glu Val Ile Leu Lys Leu Glu Ser Leu His Gln Gln Pro
                165                 170                 175     
His Ile Trp Asp Phe Leu Leu Leu Leu Pro Arg Leu His Thr Ser His
            180                 185                 190         
Asp His Val Glu Asp Gly Met Asp Val Ala Val Asn Leu Leu Gln Thr
        195                 200                 205             
Ile Leu Asn Ser Leu Ile Ser Leu Glu Asp Leu Asp Trp Leu Pro Leu
    210                 215                 220                 
Asn Gln Thr Phe Ser Gln Val Ser Glu Leu Val Leu Asn Val Thr Ile
225                 230                 235                 240 
Ser Thr Leu Thr Phe Leu Gln Gln His Gly Val Ala Val Thr Glu Pro
                245                 250                 255     
Val Tyr His Leu Ser Met Gln Asn Ile Val Trp Asp Pro Gln Lys Val
            260                 265                 270         
Gln Tyr Asp Leu Lys Ser Gln Phe Gly Phe Xaa Asp Leu His Thr Glu
        275                 280                 285             
Gln Ile Leu Asn Ser Ser Ala Glu Leu Lys Glu Ile Pro Thr Asp Thr
    290                 295                 300                 
Ser Leu Glu Lys Met Val Cys Ser Val Leu Ser Ser Thr Ser Glu Asp
305                 310                 315                 320 
Glu Ala Glu Lys Trp Gly His Val Gly Gly Cys His Pro Lys Trp Ser
                325                 330                 335     
Glu Ala Lys Asn Tyr Leu Val His Ala Val Ser Trp Leu Arg Val Tyr
            340                 345                 350         
Gln Gln Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu Gln Lys Thr
        355                 360                 365             
Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn Gln Phe Glu
    370                 375                 380                 
Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His Thr Ala Leu
385                 390                 395                 400 
Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys Asp Asn His
                405                 410                 415     
Thr Phe Pro Lys Ile Leu Gln His Leu Trp Lys Leu Gln Ser Leu Leu
            420                 425                 430         
Gln Asn Leu Pro Gln Trp Pro Ala Leu Lys Arg Phe Leu Gln Leu Asp
        435                 440                 445             
Gly Ala Leu Arg Asn Ala Ile Ala Gln Asn Leu His Phe Val Gln Glu
    450                 455                 460                 
Val Leu Ile Cys Leu Glu Thr Ser Ala Asn Asp Phe Lys Trp Phe Glu
465                 470                 475                 480 
Leu Asn Gln Leu Lys Leu Glu Lys Asp Val Phe Phe Trp Glu Leu Lys
                485                 490                 495     
Gln Met Leu Ala Lys Asn Ala Val Cys Pro Asn Gly Arg Phe Ser Glu
            500                 505                 510         
Lys Glu Val Phe Leu Pro Pro Gly Asn Ser Ser Ile Trp Gly Gly Leu
        515                 520                 525             
Gln Gly Leu Leu Cys Tyr Cys Asn Ser Ser Glu Thr Ser Val Leu Asn
    530                 535                 540                 
Lys Leu Leu Gly Ser Val Glu Asp Ala Asp Arg Ile Leu Gln Glu Val
545                 550                 555                 560 
Ile Thr Trp His Lys Asn Met Ser Val Leu Ile Pro Glu Glu Tyr Leu
                565                 570                 575     
Asp Trp Gln Glu Leu Glu Met Gln Leu Ser Glu Ala Ser Leu Ser Cys
            580                 585                 590         
Thr Arg Leu Phe Leu Leu Leu Gly Ala Asp Pro Ser Pro Glu Asn Asp
        595                 600                 605             
Val Phe Ser Ser Asp Cys Lys His Gln Leu Val Ser Thr Val Ile Phe
    610                 615                 620                 
His Thr Leu Glu Lys Thr Gln Phe Phe Leu Glu Gln Ala Tyr Tyr Trp
625                 630                 635                 640 
Lys Ala Phe Lys Lys Phe Ile Arg Lys Thr Cys Glu Val Ala Gln Tyr
                645                 650                 655     
Val Asn Met Gln Glu Ser Phe Gln Asn Arg Leu Leu Ala Phe Pro Glu
            660                 665                 670         
Glu Ser Pro Cys Phe Glu Glu Asn Met Asp Trp Lys Met Ile Ser Asp
        675                 680                 685             
Asn Tyr Phe Gln Phe Leu Asn Asn Leu Leu Lys Ser Pro Thr Ala Ser
    690                 695                 700                 
Ile Ser Arg Ala Leu Asn Phe Thr Lys His Leu Leu Met Met Glu Lys
705                 710                 715                 720 
Lys Leu His Thr Leu Glu Asp Glu Gln Met Asn Phe Leu Leu Ser Phe
                725                 730                 735     
Val Glu Phe Phe Glu Lys Leu Leu Leu Pro Asn Leu Phe Asp Ser Ser
            740                 745                 750         
Ile Val Pro Ser Phe His Ser Leu Pro Ser Leu Thr Glu Asp Ile Leu
        755                 760                 765             
Asn Ile Ser Ser Leu Trp Thr Asn His Leu Lys Ser Leu Lys Arg Asp
    770                 775                 780                 
Pro Ser Ala Thr Asp Ala Gln Lys Leu Leu Glu Phe Gly Asn Glu Val
785                 790                 795                 800 
Ile Trp Lys Met Gln Thr Leu Gly Ser His Trp Ile Arg Lys Glu Pro
                805                 810                 815     
Lys Asn Leu Leu Arg Phe Ile Glu Leu Ile Leu Phe Glu Ile Asn Pro
            820                 825                 830         
Lys Leu Leu Glu Leu Trp Ala Tyr Gly Ile Ser Lys Gly Lys Arg Ala
        835                 840                 845             
Lys Leu Glu Asn Phe Phe Thr Leu Leu Asn Phe Ser Val Pro Glu Asn
    850                 855                 860                 
Glu Ile Leu Ser Thr Ser Phe Asn Phe Ser Gln Leu Phe His Ser Asp
865                 870                 875                 880 
Trp Pro Lys Ser Pro Ala Met Asn Ile Asp Phe Val Arg Leu Ser Glu
                885                 890                 895     
Ala Ile Ile Thr Ser Leu His Glu Phe Gly Phe Leu Glu Gln Glu Gln
            900                 905                 910         
Ile Ser Glu Ala Leu Asn Thr Val Tyr Ala Ile Arg Asn Ala Ser Asp
        915                 920                 925             
Leu Phe Ser Ala Leu Ser Glu Pro Gln Lys Gln Glu Val Asp Lys Ile
    930                 935                 940                 
Leu Thr His Ile His Leu Asn Val Phe Gln Asp Lys Asp Ser Ala Leu
945                 950                 955                 960 
Leu Leu Gln Ile Tyr Ser Ser Phe Tyr Arg Tyr Ile Tyr Glu Leu Leu
                965                 970                 975     
Asn Ile Gln Ser Arg Gly Ser Ser Leu Thr Phe Leu Thr Gln Ile Ser
            980                 985                 990         
Lys His Ile Leu Asp Ile Ile Lys Gln Phe Asn Phe Gln Asn Ile Ser
        995                 1000                1005            
Lys Ala Phe Ala Phe Leu Phe Lys Thr Ala Glu Val Leu Gly Gly Ile
    1010                1015                1020                
Ser Asn Val Ser Tyr Cys Gln Gln Leu Leu Ser Ile Phe Asn Phe Leu
1025                1030                1035                1040
Glu Leu Gln Ala Gln Ser Phe Met Ser Thr Glu Gly Gln Glu Leu Glu
                1045                1050                1055    
Val Ile His Thr Thr Leu Thr Gly Leu Lys Gln Leu Leu Ile Ile Asp
            1060                1065                1070        
Glu Asp Phe Arg Ile Ser Leu Phe Gln Tyr Met Ser Gln Phe Phe Asn
        1075                1080                1085            
Ser Ser Val Glu Asp Leu Leu Asp Asn Lys Cys Leu Ile Ser Asp Asn
    1090                1095                1100                
Lys His Ile Ser Ser Val Asn Tyr Ser Thr Ser Glu Glu Ser Ser Phe
1105                1110                1115                1120
Val Phe Pro Leu Ala Gln Ile Phe Ser Asn Leu Ser Ala Asn Val Ser
                1125                1130                1135    
Val Phe Asn Lys Phe Met Ser Ile His Cys Thr Val Ser Trp Leu Gln
            1140                1145                1150        
Met Trp Thr Glu Ile Trp Glu Thr Ile Ser Gln Leu Phe Lys Phe Asp
        1155                1160                1165            
Met Asn Val Phe Thr Ser Leu His His Gly Phe Thr Gln Leu Leu Asp
    1170                1175                1180                
Glu Leu Glu Asp Asp Val Lys Val Ser Lys Ser Cys Gln Gly Ile Leu
1185                1190                1195                1200
Pro Thr His Asn Val Ala Arg Leu Ile Leu Asn Leu Phe Lys Asn Val
                1205                1210                1215    
Thr Gln Ala Asn Asp Phe His Asn Trp Glu Asp Phe Leu Asp Leu Arg
            1220                1225                1230        
Asp Phe Leu Val Ala Leu Gly Asn Ala Leu Val Ser Val Lys Lys Leu
        1235                1240                1245            
Asn Leu Glu Gln Val Glu Lys Ser Leu Phe Thr Met Glu Ala Ala Leu
    1250                1255                1260                
His Gln Leu Lys Thr Phe Pro Phe Asn Glu Ser Thr Ser Arg Glu Phe
1265                1270                1275                1280
Leu Asn Ser Leu Leu Glu Val Phe Ile Glu Phe Ser Ser Thr Ser Glu
                1285                1290                1295    
Tyr Ile Val Arg Asn Leu Asp Ser Ile Asn Asp Phe Leu Ser Asn Asn
            1300                1305                1310        
Leu Thr Asn Tyr Gly Glu Lys Phe Glu Asn Ile Ile Thr Glu Leu Arg
        1315                1320                1325            
Glu Ala Ile Val Phe Leu Arg Asn Val Ser His Asp Arg Asp Leu Phe
    1330                1335                1340                
Ser Cys Ala Asp Ile Phe Gln Asn Val Thr Glu Cys Ile Leu Glu Asp
1345                1350                1355                1360
Gly Phe Leu Tyr Val Asn Thr Ser Gln Arg Met Leu Arg Ile Leu Asp
                1365                1370                1375    
Thr Leu Asn Ser Thr Phe Ser Ser Glu Asn Thr Ile Ser Ser Leu Lys
            1380                1385                1390        
Gly Cys Ile Val Trp Leu Asp Val Ile Asn His Leu Tyr Leu Leu Ser
        1395                1400                1405            
Asn Ser Ser Phe Ser Gln Gly Arg Leu Gln Asn Ile Leu Gly Asn Phe
    1410                1415                1420                
Arg Asp Ile Glu Asn Lys Met Asn Ser Ile Leu Lys Ile Val Thr Trp
1425                1430                1435                1440
Val Leu Asn Ile Lys Lys Pro Leu Cys Ser Ser Asn Gly Ser His Ile
                1445                1450                1455    
Asn Cys Val Asn Ile Tyr Leu Lys Asp Val Thr Asp Phe Leu Asn Ile
            1460                1465                1470        
Val Leu Thr Thr Val Phe Glu Lys Glu Lys Lys Pro Lys Phe Glu Ile
        1475                1480                1485            
Leu Leu Ala Leu Leu Asn Asp Ser Thr Lys Gln Val Arg Met Ser Ile
    1490                1495                1500                
Asn Asn Leu Thr Thr Asp Phe Asp Phe Ala Ser Gln Ser Asn Trp Arg
1505                1510                1515                1520
Tyr Phe Thr Glu Leu Ile Leu Arg Pro Ile Glu Met Ser Asp Glu Ile
                1525                1530                1535    
Pro Asn Gln Phe Gln Asn Ile Trp Leu His Leu Ile Thr Leu Gly Lys
            1540                1545                1550        
Glu Phe Gln Lys Leu Val Lys Gly Ile Tyr Phe Asn Ile Leu Glu Asn
        1555                1560                1565            
Asn Ser Ser Ser Lys Thr Glu Asn Leu Leu Asn Ile Phe Ala Thr Ser
    1570                1575                1580                
Pro Lys Glu Lys Asp Val Asn Ser Val Gly Asn Ser Ile Tyr His Leu
1585                1590                1595                1600
Ala Ser Tyr Leu Ala Phe Ser Leu Ser His Asp Leu Gln Asn Ser Pro
                1605                1610                1615    
Lys Ile Ile Ile Ser Pro Glu Ile Met Lys Ala Thr Gly Leu Gly Ile
            1620                1625                1630        
Gln Leu Ile Arg Asp Val Phe Asn Ser Leu Met Pro Val Val His His
        1635                1640                1645            
Thr Ser Pro Gln Asn Ala Gly Tyr Met Gln Ala Leu Lys Lys Val Thr
    1650                1655                1660                
Ser Val Met Arg Thr Leu Lys Lys Ala Asp Ile Asp Leu Leu Val Asp
1665                1670                1675                1680
Gln Leu Glu Gln Val Ser Val Asn Leu Met Asp Phe Phe Lys Asn Ile
                1685                1690                1695    
Ser Ser Val Gly Thr Gly Asn Leu Val Val Asn Leu Leu Val Gly Leu
            1700                1705                1710        
Met Glu Lys Phe Ala Asp Ser Ser His Ser Trp Asn Val Asn His Leu
        1715                1720                1725            
Leu Gln Leu Ser Arg Leu Phe Pro Lys Asp Val Val Asp Ala Val Ile
    1730                1735                1740                
Asp Val Tyr Tyr Val Leu Pro His Ala Val Arg Leu Leu Gln Gly Val
1745                1750                1755                1760
Pro Gly Lys Asn Ile Thr Glu Gly Leu Lys Asp Val Tyr Ser Phe Thr
                1765                1770                1775    
Leu Leu His Gly Ile Thr Ile Ser Asn Ile Thr Lys Glu Asp Phe Ala
            1780                1785                1790        
Ile Val Ile Lys Ile Leu Leu Asp Thr Ile Glu Leu Val Ser Asp Lys
        1795                1800                1805            
Pro Asp Ile Ile Ser Glu Ala Leu Ala Cys Phe Pro Val Val Trp Cys
    1810                1815                1820                
Trp Asn His Thr Asn Ser Gly Phe Arg Gln Asn Ser Lys Ile Asp Pro
1825                1830                1835                1840
Cys Asn Val His Gly Leu Met Ser Ser Ser Phe Tyr Gly Lys Val Ala
                1845                1850                1855    
Ser Ile Leu Asp His Phe His Leu Ser Pro Gln Gly Glu Asp Ser Pro
            1860                1865                1870        
Cys Ser Asn Glu Ser Ser Arg Met Glu Ile Thr Arg Lys Val Val Cys
        1875                1880                1885            
Ile Ile His Glu Leu Val Asp Trp Asn Ser Ile Leu Leu Glu Leu Ser
    1890                1895                1900                
Glu Val Phe His Val Asn Ile Ser Leu Val Lys Thr Val Gln Lys Phe
1905                1910                1915                1920
Trp His Lys Ile Leu Pro Phe Val Pro Pro Ser Ile Asn Gln Thr Arg
                1925                1930                1935    
Asp Ser Ile Ser Glu Leu Cys Pro Ser Gly Ser Ile Lys Gln Val Ala
            1940                1945                1950        
Leu Gln Ile Ile Glu Lys Leu Lys Asn Val Asn Phe Thr Lys Val Thr
        1955                1960                1965            
Ser Gly Glu Asn Ile Leu Asp Lys Leu Ser Ser Leu Asn Lys Ile Leu
    1970                1975                1980                
Asn Ile Asn Glu Asp Thr Glu Thr Ser Val Gln Asn Ile Ile Ser Ser
1985                1990                1995                2000
Asn Leu Glu Arg Thr Val Gln Leu Ile Ser Glu Asp Trp Ser Leu Glu
                2005                2010                2015    
Lys Ser Thr His Asn Leu Leu Ser Leu Phe Met Met Leu Gln Asn Ala
            2020                2025                2030        
Asn Val Thr Gly Ser Ser Leu Glu Ala Leu Ser Ser Phe Ile Glu Lys
        2035                2040                2045            
Ser Glu Thr Pro Tyr Asn Phe Glu Glu Leu Trp Pro Lys Phe Gln Gln
    2050                2055                2060                
Ile Met Lys Asp Leu Thr Gln Asp Phe Arg Ile Arg His Leu Leu Ser
2065                2070                2075                2080
Glu Met Asn Lys Gly Ile Lys Ser Ile Asn Ser Met Ala Leu Gln Lys
                2085                2090                2095    
Ile Thr Leu Gln Phe Ala His Phe Leu Glu Ile Leu Asp Ser Pro Ser
            2100                2105                2110        
Leu Lys Thr Leu Glu Ile Ile Glu Asp Phe Leu Leu Val Thr Lys Asn
        2115                2120                2125            
Trp Leu Gln Glu Tyr Ala Asn Glu Asp Tyr Ser Arg Met Ile Glu Thr
    2130                2135                2140                
Leu Phe Ile Pro Val Thr Asn Glu Ser Ser Thr Glu Asp Ile Ala Leu
2145                2150                2155                2160
Leu Ala Lys Ala Ile Ala Thr Phe Trp Gly Ser Leu Lys Asn Ile Ser
                2165                2170                2175    
Arg Ala Gly Asn Phe Asp Val Ala Phe Leu Thr His Leu Leu Asn Gln
            2180                2185                2190        
Glu Gln Leu Thr Asn Phe Ser Val Val Gln Leu Leu Phe Glu Asn Ile
        2195                2200                2205            
Leu Ile Asn Leu Ile Asn Asn Leu Ala Gly Asn Ser Gln Glu Ala Ala
    2210                2215                2220                
Trp Asn Leu Asn Asp Thr Asp Leu Gln Ile Met Asn Phe Ile Asn Leu
2225                2230                2235                2240
Ile Leu Asn His Met Gln Ser Glu Thr Ser Arg Lys Thr Val Leu Ser
                2245                2250                2255    
Leu Arg Ser Ile Val Asp Phe Thr Glu Gln Phe Leu Lys Thr Phe Phe
            2260                2265                2270        
Ser Leu Phe Leu Lys Glu Asp Ser Glu Asn Lys Ile Ser Leu Leu Leu
        2275                2280                2285            
Lys Tyr Phe His Lys Asp Val Ile Ala Glu Met Ser Phe Val Pro Lys
    2290                2295                2300                
Asp Lys Ile Leu Glu Ile Leu Lys Leu Asp Gln Phe Leu Thr Leu Met
2305                2310                2315                2320
Ile Gln Asp Arg Leu Met Asn Ile Phe Ser Ser Leu Lys Glu Thr Ile
                2325                2330                2335    
Tyr His Leu Met Lys Ser Ser Phe Ile Leu Asp Asn Gly Glu Phe Tyr
            2340                2345                2350        
Phe Asp Thr His Gln Gly Leu Lys Phe Met Gln Asp Leu Phe Asn Ala
        2355                2360                2365            
Leu Leu Arg Glu Thr Ser Met Lys Asn Lys Thr Glu Asn Asn Ile Asp
    2370                2375                2380                
Phe Phe Thr Val Val Ser Gln Leu Phe Phe His Val Asn Lys Ser Glu
2385                2390                2395                2400
Asp Leu Phe Lys Leu Asn Gln Asp Leu Gly Ser Ala Leu His Leu Val
                2405                2410                2415    
Arg Glu Cys Ser Thr Glu Met Ala Arg Leu Leu Asp Thr Ile Leu His
            2420                2425                2430        
Ser Pro Asn Lys Asp Phe Tyr Ala Leu Tyr Pro Thr Leu Gln Glu Val
        2435                2440                2445            
Ile Leu Ala Asn Leu Thr Asp Leu Leu Phe Phe Ile Asn Asn Ser Phe
    2450                2455                2460                
Pro Leu Arg Asn Arg Ala Thr Leu Glu Ile Thr Lys Arg Leu Val Gly
2465                2470                2475                2480
Ala Ile Ser Arg Ala Ser Glu Glu Ser His Val Leu Lys Pro Leu Leu
                2485                2490                2495    
Glu Met Ser Gly Thr Leu Val Met Leu Leu Asn Asp Ser Ala Asp Leu
            2500                2505                2510        
Arg Asp Leu Ala Thr Ser Met Asp Ser Ile Val Lys Leu Leu Lys Leu
        2515                2520                2525            
Val Lys Lys Val Ser Gly Lys Met Ser Thr Val Phe Lys Thr His Phe
    2530                2535                2540                
Ile Ser Asn Thr Lys Asp Ser Val Lys Phe Phe Asp Thr Leu Tyr Ser
2545                2550                2555                2560
Ile Met Gln Gln Ser Val Gln Asn Leu Val Lys Glu Ile Ala Thr Leu
                2565                2570                2575    
Lys Lys Ile Asp His Phe Thr Phe Glu Lys Ile Asn Asp Leu Leu Val
            2580                2585                2590        
Pro Phe Leu Asp Leu Ala Phe Glu Met Ile Gly Val Glu Pro Tyr Ile
        2595                2600                2605            
Ser Ser Asn Ser Asp Ile Phe Ser Met Ser Pro Ser Ile Leu Ser Tyr
    2610                2615                2620                
Met Asn Gln Ser Lys Asp Phe Ser Asp Ile Leu Glu Glu Ile Ala Glu
2625                2630                2635                2640
Phe Leu Thr Ser Val Lys Met Asn Leu Glu Asp Met Arg Ser Leu Ala
                2645                2650                2655    
Val Ala Phe Asn Asn Glu Thr Gln Thr Phe Ser Met Asp Ser Val Asn
            2660                2665                2670        
Leu Xaa Glu Glu Ile Leu Gly Cys Leu Val Pro Ile Asn Asn Ile Thr
        2675                2680                2685            
Asn Gln Met Asp Phe Leu Tyr Pro Asn Pro Ile Ser Thr His Ser Gly
    2690                2695                2700                
Pro Gln Asp Ile Lys Trp Glu Ile Ile His Glu Val Ile Leu Phe Leu
2705                2710                2715                2720
Asp Lys Ile Leu Ser Gln Asn Ser Thr Glu Ile Gly Ser Phe Leu Lys
                2725                2730                2735    
Met Val Ile Cys Leu Thr Leu Glu Ala Leu Trp Lys Asn Leu Lys Lys
            2740                2745                2750        
Asp Asn Trp Asn Val Ser Asn Val Leu Met Thr Phe Thr Gln His Pro
        2755                2760                2765            
Asn Asn Leu Leu Lys Thr Ile Glu Thr Val Leu Glu Ala Ser Ser Gly
    2770                2775                2780                
Ile Lys Ser Asp Tyr Glu Gly Asp Leu Asn Lys Ser Leu Tyr Phe Asp
2785                2790                2795                2800
Thr Pro Leu Ser Gln Asn Ile Thr His His Gln Leu Glu Lys Ala Ile
                2805                2810                2815    
His Asn Val Leu Ser Arg Ile Ala Leu Trp Arg Lys Gly Leu Arg Phe
            2820                2825                2830        
Asn Asn Ser Glu Trp Ile Thr Ser Thr Arg Thr Leu Phe Gln Pro Leu
        2835                2840                2845            
Phe Glu Ile Phe Ile Lys Ala Thr Thr Gly Lys Asn Val Thr Ser Glu
    2850                2855                2860                
Lys Glu Glu Arg Thr Glu Lys Glu Met Ile Asp Phe Pro Tyr Ser Phe
2865                2870                2875                2880
Lys Pro Phe Phe Cys Leu Glu Lys Tyr Leu Gly Gly Leu Phe Val Leu
                2885                2890                2895    
Thr Lys Tyr Trp Gln Gln Ile Pro Leu Thr Asp Gln Ser Val Val Glu
            2900                2905                2910        
Ile Cys Glu Val Phe Gln Gln Thr Val Lys Pro Ser Glu Ala Met Glu
        2915                2920                2925            
Met Leu Gln Lys Val Lys Met Met Val Val Arg Val Leu Thr Ile Val
    2930                2935                2940                
Ala Glu Asn Pro Ser Trp Thr Lys Asp Ile Leu Cys Ala Thr Leu Ser
2945                2950                2955                2960
Cys Lys Gln Asn Gly Ile Arg His Leu Ile Leu Ser Ala Ile Gln Gly
                2965                2970                2975    
Val Thr Leu Ala Gln Asp His Phe Gln Glu Ile Glu Lys Ile Trp Ser
            2980                2985                2990        
Ser Pro Asn Gln Leu Asn Cys Glu Ser Leu Ser Lys Asn Leu Ser Ser
        2995                3000                3005            
Thr Leu Glu Ser Phe Lys Ser Ser Leu Glu Asn Ala Thr Gly Gln Asp
    3010                3015                3020                
Cys Thr Ser Gln Pro Arg Leu Glu Thr Val Gln Gln His Leu Tyr Met
3025                3030                3035                3040
Leu Ala Lys Ser Leu Glu Glu Thr Trp Ser Ser Gly Asn Pro Ile Met
                3045                3050                3055    
Thr Phe Leu Ser Asn Phe Thr Val Thr Glu Asp Val Lys Ile Lys Asp
            3060                3065                3070        
Leu Met Lys Asn Ile Thr Lys Leu Thr Glu Glu Leu Arg Ser Ser Ile
        3075                3080                3085            
Gln Ile Ser Asn Glu Thr Ile His Ser Ile Leu Glu Ala Asn Ile Ser
    3090                3095                3100                
His Ser Lys Val Leu Phe Ser Ala Leu Thr Val Ala Leu Ser Gly Lys
3105                3110                3115                3120
Cys Asp Gln Glu Ile Leu His Leu Leu Leu Thr Phe Pro Lys Gly Glu
                3125                3130                3135    
Lys Ser Trp Ile Ala Ala Glu Glu Leu Cys Ser Leu Pro Gly Ser Lys
            3140                3145                3150        
Val Tyr Ser Leu Ile Val Leu Leu Ser Arg Asn Leu Asp Val Arg Ala
        3155                3160                3165            
Phe Ile Tyr Lys Thr Leu Met Pro Ser Glu Ala Asn Gly Leu Leu Asn
    3170                3175                3180                
Ser Leu Leu Asp Ile Val Ser Ser Leu Ser Ala Leu Leu Ala Lys Ala
3185                3190                3195                3200
Gln His Val Phe Glu Tyr Leu Pro Glu Phe Leu His Thr Phe Lys Ile
                3205                3210                3215    
Thr Ala Leu Leu Glu Thr Leu Asp Phe Gln Gln Val Ser Gln Asn Val
            3220                3225                3230        
Gln Ala Arg Ser Ser Ala Phe Gly Ser Phe Gln Phe Val Met Lys Met
        3235                3240                3245            
Val Cys Lys Asp Gln Ala Ser Phe Leu Ser Asp Ser Asn Met Phe Ile
    3250                3255                3260                
Asn Leu Pro Arg Val Lys Glu Leu Leu Glu Asp Asp Lys Glu Lys Phe
3265                3270                3275                3280
Asn Ile Pro Glu Asp Ser Thr Pro Phe Cys Leu Lys Leu Tyr Gln Glu
                3285                3290                3295    
Ile Leu Gln Leu Pro Asn Gly Ala Leu Val Trp Thr Phe Leu Lys Pro
            3300                3305                3310        
Ile Leu His Gly Lys Ile Leu Tyr Thr Pro Asn Thr Pro Glu Ile Asn
        3315                3320                3325            
Lys Val Ile Gln Lys Ala Asn Tyr Thr Phe Tyr Ile Val Asp Lys Leu
    3330                3335                3340                
Lys Thr Leu Ser Glu Thr Leu Leu Glu Met Ser Ser Leu Phe Gln Arg
3345                3350                3355                3360
Ser Gly Ser Gly Gln Met Phe Asn Gln Leu Gln Glu Ala Leu Arg Asn
                3365                3370                3375    
Lys Phe Val Arg Asn Phe Val Glu Asn Gln Leu His Ile Asp Val Asp
            3380                3385                3390        
Lys Leu Thr Glu Lys Leu Gln Thr Tyr Gly Gly Leu Leu Asp Glu Met
        3395                3400                3405            
Phe Asn His Ala Gly Ala Gly Arg Phe Arg Phe Leu Gly Ser Ile Leu
    3410                3415                3420                
Val Asn Leu Ser Ser Cys Val Ala Leu Asn Arg Phe Gln Ala Leu Gln
3425                3430                3435                3440
Ser Val Asp Ile Leu Glu Thr Lys Ala His Glu Leu Leu Gln Gln Asn
                3445                3450                3455    
Ser Phe Leu Ala Ser Ile Ile Phe Ser Asn Ser Leu Phe Asp Lys Asn
            3460                3465                3470        
Phe Arg Ser Glu Ser Val Lys Leu Pro Pro His Val Ser Tyr Thr Ile
        3475                3480                3485            
Arg Thr Asn Val Leu Tyr Ser Val Arg Thr Asp Val Val Lys Asn Pro
    3490                3495                3500                
Ser Trp Lys Phe His Pro Gln Asn Leu Pro Ala Asp Gly Phe Lys Tyr
3505                3510                3515                3520
Asn Tyr Val Phe Ala Pro Leu Gln Asp Met Ile Glu Arg Ala Ile Ile
                3525                3530                3535    
Leu Val Gln Thr Gly Gln Glu Ala Leu Glu Pro Ala Ala Gln Thr Gln
            3540                3545                3550        
Ala Ala Pro Tyr Pro Cys His Thr Ser Asp Leu Phe Leu Asn Asn Val
        3555                3560                3565            
Gly Phe Phe Phe Pro Leu Ile Met Met Leu Thr Trp Met Val Ser Val
    3570                3575                3580                
Ala Ser Met Val Arg Lys Leu Val Tyr Glu Gln Glu Ile Gln Ile Glu
3585                3590                3595                3600
Glu Tyr Met Arg Met Met Gly Val His Pro Val Ile His Phe Leu Ala
                3605                3610                3615    
Trp Phe Leu Glu Asn Met Ala Val Leu Thr Ile Ser Ser Ala Thr Leu
            3620                3625                3630        
Ala Ile Val Leu Lys Thr Ser Gly Ile Phe Ala His Ser Asn Thr Phe
        3635                3640                3645            
Ile Val Phe Leu Phe Leu Leu Asp Phe Gly Met Ser Val Val Met Leu
    3650                3655                3660                
Ser Tyr Leu Leu Ser Ala Phe Phe Ser Gln Ala Asn Thr Ala Ala Leu
3665                3670                3675                3680
Cys Thr Ser Leu Val Tyr Met Ile Ser Phe Leu Pro Tyr Ile Val Leu
                3685                3690                3695    
Leu Val Leu His Asn Gln Leu Ser Phe Val Asn Gln Thr Phe Leu Cys
            3700                3705                3710        
Leu Leu Ser Thr Thr Ala Phe Gly Gln Gly Val Phe Phe Ile Thr Phe
        3715                3720                3725            
Leu Glu Gly Gln Glu Thr Gly Ile Gln Trp Asn Asn Met Tyr Gln Ala
    3730                3735                3740                
Leu Glu Gln Gly Gly Met Thr Phe Gly Trp Val Cys Trp Met Ile Leu
3745                3750                3755                3760
Phe Asp Ser Ser Leu Tyr Phe Leu Cys Gly Trp Tyr Leu Ser Asn Leu
                3765                3770                3775    
Ile Pro Gly Thr Phe Gly Leu Arg Lys Pro Trp Tyr Phe Pro Phe Thr
            3780                3785                3790        
Ala Ser Tyr Trp Lys Ser Val Gly Phe Leu Val Glu Lys Arg Gln Tyr
        3795                3800                3805            
Phe Leu Ser Ser Ser Leu Phe Phe Phe Asn Glu Asn Phe Asp Asn Lys
    3810                3815                3820                
Gly Ser Ser Leu Gln Asn Arg Glu Gly Glu Leu Glu Gly Ser Ala Pro
3825                3830                3835                3840
Gly Val Thr Leu Val Ser Val Thr Lys Glu Tyr Glu Gly His Lys Ala
                3845                3850                3855    
Val Val Gln Asp Leu Ser Leu Thr Phe Tyr Arg Asp Gln Ile Thr Ala
            3860                3865                3870        
Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr Thr Ile Ile Ser Met Leu
        3875                3880                3885            
Thr Gly Leu His Pro Pro Thr Ser Gly Thr Ile Ile Ile Asn Gly Lys
    3890                3895                3900                
Asn Leu Gln Thr Asp Leu Ser Arg Val Arg Met Glu Leu Gly Val Cys
3905                3910                3915                3920
Pro Gln Gln Asp Ile Leu Leu Asp Asn Leu Thr Val Arg Glu His Leu
                3925                3930                3935    
Leu Leu Phe Ala Ser Ile Lys Ala Pro Gln Trp Thr Lys Lys Glu Leu
            3940                3945                3950        
His Gln Gln Val Asn Gln Thr Leu Gln Asp Val Asp Leu Thr Gln His
        3955                3960                3965            
Gln His Lys Gln Thr Arg Ala Leu Ser Gly Gly Leu Lys Arg Lys Leu
    3970                3975                3980                
Ser Leu Gly Ile Ala Phe Met Gly Met Ser Arg Thr Val Val Leu Asp
3985                3990                3995                4000
Glu Pro Thr Ser Gly Val Asp Pro Cys Ser Arg His Ser Leu Trp Asp
                4005                4010                4015    
Ile Leu Leu Lys Tyr Arg Glu Gly Arg Thr Ile Ile Phe Thr Thr His
            4020                4025                4030        
His Leu Asp Glu Ala Glu Ala Leu Ser Asp Arg Val Ala Val Leu Gln
        4035                4040                4045            
His Gly Arg Leu Arg Cys Cys Gly Pro Pro Phe Cys Leu Lys Glu Ala
    4050                4055                4060                
Tyr Gly Gln Gly Leu Arg Leu Thr Leu Thr Arg Gln Pro Ser Val Leu
4065                4070                4075                4080
Glu Ala His Asp Leu Lys Asp Met Ala Cys Val Thr Ser Leu Ile Lys
                4085                4090                4095    
Ile Tyr Ile Pro Gln Ala Phe Leu Lys Asp Ser Ser Gly Ser Glu Leu
            4100                4105                4110        
Thr Tyr Thr Ile Pro Lys Asp Thr Asp Lys Ala Cys Leu Lys Gly Leu
        4115                4120                4125            
Phe Gln Ala Leu Asp Glu Asn Leu His Gln Leu His Leu Thr Gly Tyr
    4130                4135                4140                
Gly Ile Ser Asp Thr Thr Leu Glu Glu Val Phe Leu Met Leu Leu Gln
4145                4150                4155                4160
Asp Ser Asn Lys Lys Ser His Ile Ala Leu Gly Thr Glu Ser Glu Leu
                4165                4170                4175    
Gln Asn His Arg Pro Thr Gly His Leu Ser Gly Tyr Cys Gly Ser Leu
            4180                4185                4190        
Ala Arg Pro Ala Thr Val Gln Gly Val Gln Leu Leu Arg Ala Gln Val
        4195                4200                4205            
Ala Ala Ile Leu Ala Arg Arg Leu Arg Arg Thr Leu Arg Ala Gly Lys
    4210                4215                4220                
Ser Thr Leu Ala Asp Leu Leu Leu Pro Val Leu Phe Val Ala Leu Ala
4225                4230                4235                4240
Met Gly Leu Phe Met Val Arg Pro Leu Ala Thr Glu Tyr Pro Pro Leu
                4245                4250                4255    
Arg Leu Thr Pro Gly His Tyr Gln Arg Ala Glu Thr Tyr Phe Phe Ser
            4260                4265                4270        
Ser Gly Gly Asp Asn Leu Asp Leu Thr Arg Val Leu Leu Arg Lys Phe
        4275                4280                4285            
Arg Asp Gln Asp Leu Pro Cys Ala Asp Leu Asn Pro Arg Gln Lys Asn
    4290                4295                4300                
Ser Ser Cys Trp Arg Thr Asp Pro Phe Ser His Pro Glu Phe Gln Asp
4305                4310                4315                4320
Ser Cys Gly Cys Leu Lys Cys Pro Asn Arg Ser Ala Ser Ala Pro Tyr
                4325                4330                4335    
Leu Thr Asn His Leu Gly His Thr Leu Leu Asn Leu Ser Gly Phe Asn
            4340                4345                4350        
Met Glu Glu Tyr Leu Leu Ala Pro Ser Glu Lys Pro Arg Leu Gly Gly
        4355                4360                4365            
Trp Ser Phe Gly Leu Lys Ile Pro Ser Glu Ala Gly Gly Ala Asn Gly
    4370                4375                4380                
Asn Ile Ser Lys Pro Pro Thr Leu Ala Lys Val Trp Tyr Asn Gln Lys
4385                4390                4395                4400
Gly Phe His Ser Leu Pro Ser Tyr Leu Asn His Leu Asn Asn Leu Ile
                4405                4410                4415    
Leu Trp Gln His Leu Pro Pro Thr Val Asp Trp Arg Gln Tyr Gly Ile
            4420                4425                4430        
Thr Leu Tyr Ser His Pro Tyr Gly Gly Ala Leu Leu Asn Glu Asp Lys
        4435                4440                4445            
Ile Leu Glu Ser Ile Arg Gln Cys Gly Val Ala Leu Cys Ile Val Leu
    4450                4455                4460                
Gly Phe Ser Ile Leu Ser Ala Ser Ile Gly Ser Ser Val Val Arg Asp
4465                4470                4475                4480
Arg Val Ile Gly Ala Lys Arg Leu Gln His Ile Ser Gly Leu Gly Tyr
                4485                4490                4495    
Arg Met Tyr Trp Phe Thr Asn Phe Leu Tyr Asp Met Leu Phe Tyr Leu
            4500                4505                4510        
Val Ser Val Cys Leu Cys Val Ala Val Ile Val Ala Phe Gln Leu Thr
        4515                4520                4525            
Ala Phe Thr Phe Arg Lys Asn Leu Ala Ala Thr Ala Leu Leu Leu Ser
    4530                4535                4540                
Leu Phe Gly Tyr Ala Thr Leu Pro Trp Met Tyr Leu Met Ser Arg Ile
4545                4550                4555                4560
Phe Ser Ser Ser Asp Val Ala Phe Ile Ser Tyr Val Ser Leu Asn Phe
                4565                4570                4575    
Ile Phe Gly Leu Cys Thr Met Pro Ile Thr Ile Met Pro Arg Leu Leu
            4580                4585                4590        
Ala Ile Ile Ser Lys Ala Lys Asn Leu Gln Asn Ile Tyr Asp Val Leu
        4595                4600                4605            
Lys Trp Val Phe Thr Ile Phe Pro Gln Phe Cys Leu Gly Gln Gly Leu
    4610                4615                4620                
Val Glu Leu Cys Tyr Asn Gln Ile Lys Tyr Asp Leu Thr His Asn Phe
4625                4630                4635                4640
Gly Ile Asp Ser Tyr Val Ser Pro Phe Glu Met Asn Phe Leu Gly Trp
                4645                4650                4655    
Ile Phe Val Gln Leu Ala Ser Gln Gly Thr Val Leu Leu Leu Leu Arg
            4660                4665                4670        
Val Leu Leu His Trp Asp Leu Leu Arg Trp Pro Arg Gly His Ser Thr
        4675                4680                4685            
Leu Gln Gly Thr Val Lys Ser Ser Lys Asp Thr Asp Val Glu Lys Glu
    4690                4695                4700                
Glu Lys Arg Val Phe Glu Gly Arg Thr Asn Gly Asp Ile Leu Val Leu
4705                4710                4715                4720
Tyr Asn Leu Ser Lys His Tyr Arg Arg Phe Phe Gln Asn Ile Ile Ala
                4725                4730                4735    
Val Gln Asp Ile Ser Leu Gly Ile Pro Lys Gly Glu Cys Phe Gly Leu
            4740                4745                4750        
Leu Gly Val Asn Gly Ala Gly Lys Ser Thr Thr Phe Lys Met Leu Asn
        4755                4760                4765            
Gly Glu Val Ser Leu Thr Ser Gly His Ala Ile Ile Arg Thr Pro Met
    4770                4775                4780                
Gly Asp Ala Val Asp Leu Ser Ser Ala Gly Thr Ala Gly Val Leu Ile
4785                4790                4795                4800
Gly Tyr Cys Pro Gln Gln Asp Ala Leu Asp Glu Leu Leu Thr Gly Trp
                4805                4810                4815    
Glu His Leu Tyr Tyr Tyr Cys Ser Leu Arg Gly Ile Pro Arg Gln Cys
            4820                4825                4830        
Ile Pro Glu Val Ala Gly Asp Leu Ile Arg Arg Leu His Leu Glu Ala
        4835                4840                4845            
His Ala Asp Lys Pro Val Ala Thr Tyr Ser Gly Gly Thr Lys Arg Lys
    4850                4855                4860                
Leu Ser Thr Ala Leu Ala Leu Val Gly Lys Pro Asp Ile Leu Leu Leu
4865                4870                4875                4880
Asp Glu Pro Ser Ser Gly Met Asp Pro Cys Ser Lys Arg Tyr Leu Trp
                4885                4890                4895    
Gln Thr Ile Met Lys Glu Val Arg Glu Gly Cys Ala Ala Val Leu Thr
            4900                4905                4910        
Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile
        4915                4920                4925            
Met Val Asn Gly Ser Phe Lys Cys Leu Gly Ser Pro Gln His Ile Lys
    4930                4935                4940                
Asn Arg Phe Gly Asp Gly Tyr Thr Val Lys Val Trp Leu Cys Lys Glu
4945                4950                4955                4960
Ala Asn Gln His Cys Thr Val Ser Asp His Leu Lys Leu Tyr Phe Pro
                4965                4970                4975    
Gly Ile Gln Phe Lys Gly Gln His Leu Asn Leu Leu Glu Tyr His Val
            4980                4985                4990        
Pro Lys Arg Trp Gly Cys Leu Ala Asp Leu Phe Lys Val Ile Glu Asn
        4995                5000                5005            
Asn Lys Thr Phe Leu Asn Ile Lys His Tyr Ser Ile Asn Gln Thr Thr
    5010                5015                5020                
Leu Glu Gln Val Phe Ile Asn Phe Ala Ser Glu Gln Gln Gln Thr Leu
5025                5030                5035                5040
Gln Ser Thr Leu Asp Pro Ser Thr Asp Ser His His Thr His His Leu
                5045                5050                5055    
Pro Ile
        


<210> 9185
<211> 906
<212> PRT
<213> Homo sapiens

<400> 9185
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser
 1               5                  10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ser Lys
            180                 185                 190         
Lys Arg Asn Tyr Glu Asn Leu Asp Gln Leu Ser Tyr Asp Asn Lys Arg
        195                 200                 205             
Gly Pro Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn
    210                 215                 220                 
Val Thr Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile
225                 230                 235                 240 
Ile Leu Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala
                245                 250                 255     
Ala Met Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu
            260                 265                 270         
Arg Glu Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu
        275                 280                 285             
Gly Leu Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp
    290                 295                 300                 
Ala Val Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu
305                 310                 315                 320 
Asn Ile Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp
                325                 330                 335     
Lys Thr Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala
            340                 345                 350         
Asp Gly Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys
        355                 360                 365             
Phe Ala Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln
    370                 375                 380                 
Val Gly Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile
385                 390                 395                 400 
Ile Trp Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser
                405                 410                 415     
Thr Arg Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr Val
            420                 425                 430         
Lys Pro Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn
        435                 440                 445             
Gly Asp Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser
    450                 455                 460                 
Pro Gly Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys
465                 470                 475                 480 
Ile Asp Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu
                485                 490                 495     
Val His Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn
            500                 505                 510         
Asn Ser Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser
        515                 520                 525             
Gly Gln Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg
    530                 535                 540                 
Ala Gln Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr
545                 550                 555                 560 
Met Leu Val Lys Lys Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met
                565                 570                 575     
Gln Pro Phe Gln Ser Thr Leu Trp Leu Leu Val Gly Leu Ser Val His
            580                 585                 590         
Val Val Ala Val Met Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly
        595                 600                 605             
Arg Phe Lys Val Asn Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu
    610                 615                 620                 
Ser Ser Ala Met Trp Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile
625                 630                 635                 640 
Gly Glu Gly Ala Pro Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val
                645                 650                 655     
Trp Ala Gly Phe Ala Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu
            660                 665                 670         
Ala Ala Phe Leu Val Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile
        675                 680                 685             
Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ser Thr
    690                 695                 700                 
Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu
705                 710                 715                 720 
Ser Thr Met Tyr Arg His Met Glu Lys His Asn Tyr Glu Ser Ala Ala
                725                 730                 735     
Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp
            740                 745                 750         
Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val
        755                 760                 765             
Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg
    770                 775                 780                 
Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser
785                 790                 795                 800 
His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr
                805                 810                 815     
Gln Glu Cys Asp Ser Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu
            820                 825                 830         
Asn Met Ala Gly Val Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly
        835                 840                 845             
Ile Phe Leu Ile Phe Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala
    850                 855                 860                 
Arg Arg Lys Gln Met Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg
865                 870                 875                 880 
Lys Asn Leu Gln Gln Tyr His Pro Thr Asp Ile Thr Gly Pro Leu Asn
                885                 890                 895     
Leu Ser Asp Pro Ser Val Ser Thr Val Val
            900                 905     


<210> 9186
<211> 885
<212> PRT
<213> Homo sapiens

<400> 9186
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser
 1               5                  10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile
385                 390                 395                 400 
Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser
                405                 410                 415     
Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys
            420                 425                 430         
Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg
        435                 440                 445             
His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile
    450                 455                 460                 
Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala
465                 470                 475                 480 
Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys
                485                 490                 495     
Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met
            500                 505                 510         
Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu
        515                 520                 525             
Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys
    530                 535                 540                 
Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser
545                 550                 555                 560 
Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met
                565                 570                 575     
Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn
            580                 585                 590         
Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp
        595                 600                 605             
Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro
    610                 615                 620                 
Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala
625                 630                 635                 640 
Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val
                645                 650                 655     
Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu
            660                 665                 670         
Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser
        675                 680                 685             
Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg
    690                 695                 700                 
His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala
705                 710                 715                 720 
Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu
                725                 730                 735     
Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu
            740                 745                 750         
Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp
        755                 760                 765             
Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe
    770                 775                 780                 
Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser
785                 790                 795                 800 
Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val
                805                 810                 815     
Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe
            820                 825                 830         
Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met
        835                 840                 845             
Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Gln
    850                 855                 860                 
Tyr His Pro Thr Asp Ile Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser
865                 870                 875                 880 
Val Ser Thr Val Val
                885 


<210> 9187
<211> 901
<212> PRT
<213> Homo sapiens

<400> 9187
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser
 1               5                  10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile
385                 390                 395                 400 
Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser
                405                 410                 415     
Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys
            420                 425                 430         
Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg
        435                 440                 445             
His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile
    450                 455                 460                 
Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala
465                 470                 475                 480 
Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys
                485                 490                 495     
Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met
            500                 505                 510         
Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu
        515                 520                 525             
Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys
    530                 535                 540                 
Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser
545                 550                 555                 560 
Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met
                565                 570                 575     
Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn
            580                 585                 590         
Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp
        595                 600                 605             
Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro
    610                 615                 620                 
Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala
625                 630                 635                 640 
Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val
                645                 650                 655     
Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu
            660                 665                 670         
Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser
        675                 680                 685             
Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg
    690                 695                 700                 
His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala
705                 710                 715                 720 
Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu
                725                 730                 735     
Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu
            740                 745                 750         
Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp
        755                 760                 765             
Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe
    770                 775                 780                 
Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser
785                 790                 795                 800 
Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val
                805                 810                 815     
Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe
            820                 825                 830         
Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met
        835                 840                 845             
Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Ser
    850                 855                 860                 
Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln Lys Asp Thr Val Leu
865                 870                 875                 880 
Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln Leu Gln Leu Cys Ser
                885                 890                 895     
Arg His Arg Glu Ser
            900     


<210> 9188
<211> 938
<212> PRT
<213> Homo sapiens

<400> 9188
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser
 1               5                  10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile
385                 390                 395                 400 
Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser
                405                 410                 415     
Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys
            420                 425                 430         
Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg
        435                 440                 445             
His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile
    450                 455                 460                 
Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala
465                 470                 475                 480 
Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys
                485                 490                 495     
Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met
            500                 505                 510         
Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu
        515                 520                 525             
Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys
    530                 535                 540                 
Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser
545                 550                 555                 560 
Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met
                565                 570                 575     
Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn
            580                 585                 590         
Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp
        595                 600                 605             
Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro
    610                 615                 620                 
Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala
625                 630                 635                 640 
Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val
                645                 650                 655     
Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu
            660                 665                 670         
Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser
        675                 680                 685             
Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg
    690                 695                 700                 
His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala
705                 710                 715                 720 
Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu
                725                 730                 735     
Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu
            740                 745                 750         
Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp
        755                 760                 765             
Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe
    770                 775                 780                 
Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser
785                 790                 795                 800 
Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val
                805                 810                 815     
Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe
            820                 825                 830         
Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met
        835                 840                 845             
Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Asp
    850                 855                 860                 
Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys Lys Lys Ala Thr Phe
865                 870                 875                 880 
Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe Lys Arg Arg Arg Ser
                885                 890                 895     
Ser Lys Asp Thr Ser Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln
            900                 905                 910         
Lys Asp Thr Val Leu Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln
        915                 920                 925             
Leu Gln Leu Cys Ser Arg His Arg Glu Ser
    930                 935             


<210> 9189
<211> 345
<212> PRT
<213> Homo sapiens

<400> 9189
Ser Thr Gly Gly Lys Arg Arg Arg Lys Leu Arg Lys Ala Ala His Leu
 1               5                  10                  15      
Glu Val His Arg Glu Gly Asp Gly Ser Ser Thr Thr Gly Asn Thr Gln
            20                  25                  30          
Glu Gly Ala Val Gln Asn His Gly Thr Ser Thr Ser His Ser Val Gly
        35                  40                  45              
Thr Val Phe Arg Asp Leu Trp His Ala Ala Phe Phe Leu Ser Gly Ser
    50                  55                  60                  
Lys Lys Ala Lys Asn Ser Ile Asp Lys Ser Thr Glu Thr Asp Asn Gly
65                  70                  75                  80  
Tyr Val Ser Leu Asp Gly Lys Lys Thr Val Lys Ser Gly Glu Asp Gly
                85                  90                  95      
Ile Gln Asn His Glu Pro Gln Cys Glu Thr Ile Arg Pro Glu Glu Thr
            100                 105                 110         
Ala Trp Asn Thr Gly Thr Leu Arg Asn Gly Pro Ser Lys Asp Thr Gln
        115                 120                 125             
Arg Thr Ile Thr Asn Val Ser Asp Glu Val Ser Ser Glu Glu Gly Pro
    130                 135                 140                 
Glu Thr Gly Tyr Ser Leu Arg Arg His Val Asp Arg Thr Ser Glu Gly
145                 150                 155                 160 
Val Leu Arg Asn Arg Lys Ser His His Tyr Lys Lys His Tyr Pro Asn
                165                 170                 175     
Glu Asp Ala Pro Lys Ser Gly Thr Ser Cys Ser Ser Arg Cys Ser Ser
            180                 185                 190         
Ser Arg Gln Asp Ser Glu Ser Ala Arg Pro Glu Ser Glu Thr Glu Asp
        195                 200                 205             
Val Leu Trp Glu Asp Leu Leu His Cys Ala Glu Cys His Ser Ser Cys
    210                 215                 220                 
Thr Ser Glu Thr Asp Val Glu Asn His Gln Ile Asn Pro Cys Val Lys
225                 230                 235                 240 
Lys Glu Tyr Arg Asp Asp Pro Phe His Gln Val Asn Ser His Ile Pro
                245                 250                 255     
Gly Ile Gly Tyr Gln Ile Phe Gly Asn Ala Val Ser Leu Ile Leu Gly
            260                 265                 270         
Leu Thr Pro Phe Val Phe Arg Leu Ser Gln Ala Thr Asp Leu Glu Gln
        275                 280                 285             
Leu Thr Ala His Ser Ala Ser Glu Leu Tyr Val Ile Ala Phe Gly Ser
    290                 295                 300                 
Asn Glu Asp Val Ile Val Leu Ser Met Val Ile Ile Ser Phe Val Val
305                 310                 315                 320 
Arg Val Ser Leu Val Trp Ile Phe Phe Phe Leu Leu Cys Val Ala Glu
                325                 330                 335     
Arg Thr Tyr Lys Gln Val Gly Ile Met
            340                 345 


<210> 9190
<211> 356
<212> PRT
<213> Homo sapiens

<400> 9190
Met Ala Ser Lys Val Thr Asp Ala Ile Val Trp Tyr Gln Lys Lys Ile
 1               5                  10                  15      
Gly Ala Tyr Asp Gln Gln Ile Trp Glu Lys Ser Val Glu Gln Arg Glu
            20                  25                  30          
Ile Lys Phe Ile Lys Leu Gly Leu Arg Asn Lys Pro Lys Lys Thr Ala
        35                  40                  45              
His Val Lys Pro Asp Leu Ile Asp Val Asp Leu Val Arg Gly Ser Ala
    50                  55                  60                  
Phe Ala Lys Ala Lys Pro Glu Ser Pro Trp Thr Ser Leu Thr Arg Lys
65                  70                  75                  80  
Gly Ile Val Arg Val Val Phe Phe Pro Phe Phe Phe Arg Trp Trp Leu
                85                  90                  95      
Gln Val Thr Ser Lys Val Ile Phe Phe Trp Leu Leu Val Leu Tyr Leu
            100                 105                 110         
Leu Gln Val Ala Ala Ile Val Leu Phe Cys Ser Thr Ser Ser Pro His
        115                 120                 125             
Ser Ile Pro Leu Thr Glu Val Ile Gly Pro Ile Trp Leu Met Leu Leu
    130                 135                 140                 
Leu Gly Thr Val His Cys Gln Ile Val Ser Thr Arg Thr Pro Lys Pro
145                 150                 155                 160 
Pro Leu Ser Thr Gly Gly Lys Arg Arg Arg Lys Leu Arg Lys Ala Ala
                165                 170                 175     
His Leu Glu Val His Arg Glu Gly Asp Gly Ser Ser Thr Thr Asp Asn
            180                 185                 190         
Thr Gln Glu Gly Ala Val Gln Asn His Gly Thr Ser Thr Ser His Ser
        195                 200                 205             
Val Gly Thr Val Phe Arg Asp Leu Trp His Ala Ala Phe Phe Leu Ser
    210                 215                 220                 
Gly Ser Lys Lys Ala Lys Asn Ser Ile Asp Lys Ser Thr Glu Thr Asp
225                 230                 235                 240 
Asn Gly Tyr Val Ser Leu Asp Gly Lys Lys Thr Val Lys Ser Gly Glu
                245                 250                 255     
Asp Gly Ile Gln Asn His Glu Pro Gln Cys Glu Thr Ile Arg Pro Glu
            260                 265                 270         
Glu Thr Ala Trp Asn Thr Gly Thr Leu Arg Asn Gly Pro Ser Lys Asp
        275                 280                 285             
Thr Gln Arg Thr Ile Thr Asn Val Ser Asp Glu Val Ser Ser Glu Glu
    290                 295                 300                 
Gly Pro Glu Thr Gly Tyr Ser Leu Arg Arg His Val Asp Arg Thr Ser
305                 310                 315                 320 
Glu Gly Val Leu Arg Asn Arg Lys Ser His His Tyr Lys Lys His Tyr
                325                 330                 335     
Pro Asn Glu Val Tyr Thr Leu Ser Leu Ser Val Tyr Ile His Ile Tyr
            340                 345                 350         
Phe Ile Cys Tyr
        355     


<210> 9191
<211> 785
<212> PRT
<213> Homo sapiens

<400> 9191
Met Ala Pro Lys Val Thr Asp Ala Ile Val Trp Tyr Gln Lys Lys Glu
 1               5                  10                  15      
Phe Leu Ser Val Ala Thr Thr Ala Pro Gly Pro Gln Gln Val Leu Pro
            20                  25                  30          
Gly Tyr Cys Gln Cys Ser Leu Lys Asp Gln Gly Leu Phe Ile Gln Cys
        35                  40                  45              
Leu Ile Gly Ala Tyr Asp Gln Gln Ile Trp Glu Lys Ser Val Glu Gln
    50                  55                  60                  
Arg Glu Ile Lys Phe Ile Lys Leu Gly Leu Arg Asn Lys Pro Lys Lys
65                  70                  75                  80  
Thr Ala His Val Lys Pro Asp Leu Ile Asp Val Asp Leu Val Arg Gly
                85                  90                  95      
Ser Ala Phe Ala Lys Ala Lys Pro Glu Ser Pro Trp Thr Ser Leu Thr
            100                 105                 110         
Arg Lys Gly Ile Val Arg Val Val Phe Phe Pro Phe Phe Phe Arg Trp
        115                 120                 125             
Trp Leu Gln Val Thr Ser Lys Val Ile Phe Phe Trp Leu Leu Val Leu
    130                 135                 140                 
Tyr Leu Leu Gln Val Ala Ala Ile Val Leu Phe Cys Ser Thr Ser Ser
145                 150                 155                 160 
Pro His Ser Ile Pro Leu Thr Glu Val Ile Gly Pro Ile Trp Leu Met
                165                 170                 175     
Leu Leu Leu Gly Thr Val His Cys Gln Ile Val Ser Thr Arg Thr Pro
            180                 185                 190         
Lys Pro Pro Leu Ser Thr Gly Gly Lys Arg Arg Arg Lys Leu Arg Lys
        195                 200                 205             
Ala Ala His Leu Glu Val His Arg Glu Gly Asp Gly Ser Ser Thr Thr
    210                 215                 220                 
Asp Asn Thr Gln Glu Gly Ala Val Gln Asn His Gly Thr Ser Thr Ser
225                 230                 235                 240 
His Ser Val Gly Thr Val Phe Arg Asp Leu Trp His Ala Ala Phe Phe
                245                 250                 255     
Leu Ser Gly Ser Lys Lys Ala Lys Asn Ser Ile Asp Lys Ser Thr Glu
            260                 265                 270         
Thr Asp Asn Gly Tyr Val Ser Leu Asp Gly Lys Lys Thr Val Lys Ser
        275                 280                 285             
Gly Glu Asp Gly Ile Gln Asn His Glu Pro Gln Cys Glu Thr Ile Arg
    290                 295                 300                 
Pro Glu Glu Thr Ala Trp Asn Thr Gly Thr Leu Arg Asn Gly Pro Ser
305                 310                 315                 320 
Lys Asp Thr Gln Arg Thr Ile Thr Asn Val Ser Asp Glu Val Ser Ser
                325                 330                 335     
Glu Glu Gly Pro Glu Thr Gly Tyr Ser Leu Arg Arg His Val Asp Arg
            340                 345                 350         
Thr Ser Glu Gly Val Leu Arg Asn Arg Lys Ser His His Tyr Lys Lys
        355                 360                 365             
His Tyr Pro Asn Glu Asp Ala Pro Lys Ser Gly Thr Ser Cys Ser Ser
    370                 375                 380                 
Arg Cys Ser Ser Ser Arg Gln Asp Ser Glu Ser Ala Arg Pro Glu Ser
385                 390                 395                 400 
Glu Thr Glu Asp Val Leu Trp Glu Asp Leu Leu His Cys Ala Glu Cys
                405                 410                 415     
His Ser Ser Cys Thr Ser Glu Thr Asp Val Glu Asn His Gln Ile Asn
            420                 425                 430         
Pro Cys Val Lys Lys Glu Tyr Arg Asp Asp Pro Phe His Gln Ser His
        435                 440                 445             
Leu Pro Trp Leu His Ser Ser His Pro Gly Leu Glu Lys Ile Ser Ala
    450                 455                 460                 
Ile Val Trp Glu Gly Asn Asp Cys Lys Lys Ala Asp Met Ser Val Leu
465                 470                 475                 480 
Glu Ile Ser Gly Met Ile Met Asn Arg Val Asn Ser His Ile Pro Gly
                485                 490                 495     
Ile Gly Tyr Gln Ile Phe Gly Asn Ala Val Ser Leu Ile Leu Gly Leu
            500                 505                 510         
Thr Pro Phe Val Phe Arg Leu Ser Gln Ala Thr Asp Leu Glu Gln Leu
        515                 520                 525             
Thr Ala His Ser Ala Ser Glu Leu Tyr Val Ile Ala Phe Gly Ser Asn
    530                 535                 540                 
Glu Asp Val Ile Val Leu Ser Met Val Ile Ile Ser Phe Val Val Arg
545                 550                 555                 560 
Val Ser Leu Val Trp Ile Phe Phe Phe Leu Leu Cys Val Ala Glu Arg
                565                 570                 575     
Thr Tyr Lys Gln Arg Leu Leu Phe Ala Lys Leu Phe Gly His Leu Thr
            580                 585                 590         
Ser Ala Arg Arg Ala Arg Lys Ser Glu Val Pro His Phe Arg Leu Lys
        595                 600                 605             
Lys Val Gln Asn Ile Lys Met Trp Leu Ser Leu Arg Ser Tyr Leu Lys
    610                 615                 620                 
Arg Arg Gly Pro Gln Arg Ser Val Asp Val Ile Val Ser Ser Ala Phe
625                 630                 635                 640 
Leu Leu Thr Ile Ser Val Val Phe Ile Cys Cys Ala Gln Leu Leu His
                645                 650                 655     
Val His Glu Ile Phe Leu Asp Cys His Tyr Asn Trp Glu Leu Val Ile
            660                 665                 670         
Trp Cys Ile Ser Leu Thr Leu Phe Leu Leu Arg Phe Val Thr Leu Gly
        675                 680                 685             
Ser Glu Thr Ser Lys Lys Tyr Ser Asn Thr Ser Ile Leu Leu Thr Glu
    690                 695                 700                 
Gln Ile Asn Leu Tyr Leu Lys Met Glu Lys Lys Pro Asn Lys Lys Glu
705                 710                 715                 720 
Glu Leu Thr Leu Val Asn Asn Val Leu Lys Leu Ala Thr Lys Leu Leu
                725                 730                 735     
Lys Glu Leu Asp Ser Pro Phe Arg Leu Tyr Gly Leu Thr Met Asn Pro
            740                 745                 750         
Leu Leu Tyr Asn Ile Thr Gln Val Val Ile Leu Ser Ala Val Ser Gly
        755                 760                 765             
Val Ile Ser Asp Leu Leu Gly Phe Asn Leu Lys Leu Trp Lys Ile Lys
    770                 775                 780                 
Ser
785 


<210> 9192
<211> 588
<212> PRT
<213> Homo sapiens

<400> 9192
Gly Leu Arg Asn Lys Pro Lys Lys Thr Ala His Val Lys Pro Asp Leu
 1               5                  10                  15      
Ile Asp Val Asp Leu Val Arg Gly Ser Ala Phe Ala Lys Ala Lys Pro
            20                  25                  30          
Glu Ser Pro Trp Thr Ser Leu Thr Arg Lys Gly Ile Val Arg Val Val
        35                  40                  45              
Phe Phe Pro Phe Phe Phe Arg Trp Trp Leu Gln Val Thr Ser Lys Val
    50                  55                  60                  
Ile Phe Phe Trp Leu Leu Val Leu Tyr Leu Leu Gln Val Ala Ala Ile
65                  70                  75                  80  
Val Leu Phe Cys Ser Thr Ser Ser Pro His Ser Ile Pro Leu Thr Glu
                85                  90                  95      
Val Ile Gly Pro Ile Trp Leu Met Leu Leu Leu Gly Thr Val His Cys
            100                 105                 110         
Gln Ile Val Ser Thr Arg Thr Pro Lys Pro Pro Leu Ser Thr Gly Gly
        115                 120                 125             
Lys Arg Arg Arg Lys Leu Arg Lys Ala Ala His Leu Glu Val His Arg
    130                 135                 140                 
Glu Gly Asp Gly Ser Ser Thr Thr Asp Asn Thr Gln Glu Gly Ala Val
145                 150                 155                 160 
Gln Asn His Gly Thr Ser Thr Ser His Ser Val Gly Thr Val Phe Arg
                165                 170                 175     
Asp Leu Trp His Ala Ala Phe Phe Leu Ser Gly Ser Lys Lys Ala Lys
            180                 185                 190         
Asn Ser Ile Asp Lys Ser Thr Glu Thr Asp Asn Gly Tyr Val Ser Leu
        195                 200                 205             
Asp Gly Lys Lys Thr Val Lys Ser Gly Glu Asp Gly Ile Gln Asn His
    210                 215                 220                 
Glu Pro Gln Cys Glu Thr Ile Arg Pro Glu Glu Thr Ala Trp Asn Thr
225                 230                 235                 240 
Gly Thr Leu Arg Asn Gly Pro Ser Lys Asp Thr Gln Arg Thr Ile Thr
                245                 250                 255     
Asn Val Ser Asp Glu Val Ser Ser Glu Glu Gly Pro Glu Thr Gly Tyr
            260                 265                 270         
Ser Leu Arg Arg His Val Asp Arg Thr Ser Glu Gly Val Leu Arg Asn
        275                 280                 285             
Arg Lys Ser His His Tyr Lys Lys His Tyr Pro Asn Glu Asp Ala Pro
    290                 295                 300                 
Lys Ser Gly Thr Ser Cys Ser Ser Arg Cys Ser Ser Ser Arg Gln Asp
305                 310                 315                 320 
Ser Glu Ser Ala Arg Pro Glu Ser Glu Thr Glu Asp Val Leu Trp Glu
                325                 330                 335     
Asp Leu Leu His Cys Ala Glu Cys His Ser Ser Cys Thr Ser Glu Thr
            340                 345                 350         
Asp Val Glu Asn His Gln Ile Asn Pro Cys Val Lys Lys Glu Tyr Arg
        355                 360                 365             
Asp Asp Pro Phe His Gln Ser His Leu Pro Trp Leu His Ser Ser His
    370                 375                 380                 
Pro Gly Leu Glu Lys Ile Ser Ala Ile Val Trp Glu Gly Asn Asp Cys
385                 390                 395                 400 
Lys Lys Ala Asp Met Ser Val Leu Glu Ile Ser Gly Met Ile Met Asn
                405                 410                 415     
Arg Val Asn Ser His Ile Pro Gly Ile Gly Tyr Gln Ile Phe Gly Asn
            420                 425                 430         
Ala Val Ser Leu Ile Leu Gly Leu Thr Pro Phe Val Phe Arg Leu Ser
        435                 440                 445             
Gln Ala Thr Asp Leu Glu Gln Leu Thr Ala His Ser Ala Ser Glu Leu
    450                 455                 460                 
Tyr Val Ile Ala Phe Gly Ser Asn Glu Asp Val Ile Val Leu Ser Met
465                 470                 475                 480 
Val Ile Ile Ser Phe Val Val Arg Val Ser Leu Val Trp Ile Phe Phe
                485                 490                 495     
Phe Leu Leu Cys Val Ala Glu Arg Thr Tyr Lys Gln Ile Asn Leu Tyr
            500                 505                 510         
Leu Lys Met Glu Lys Lys Pro Asn Lys Lys Glu Glu Leu Thr Leu Val
        515                 520                 525             
Asn Asn Val Leu Lys Leu Ala Thr Lys Leu Leu Lys Glu Leu Asp Ser
    530                 535                 540                 
Pro Phe Arg Leu Tyr Gly Leu Thr Met Asn Pro Leu Leu Tyr Asn Ile
545                 550                 555                 560 
Thr Gln Val Val Ile Leu Ser Ala Val Ser Gly Val Ile Ser Asp Leu
                565                 570                 575     
Leu Gly Phe Asn Leu Lys Leu Trp Lys Ile Lys Ser
            580                 585             


<210> 9193
<211> 695
<212> PRT
<213> Homo sapiens

<400> 9193
Met Ala Ser Lys Val Thr Asp Ala Ile Val Trp Tyr Gln Lys Lys Ile
 1               5                  10                  15      
Gly Ala Tyr Asp Gln Gln Ile Trp Glu Lys Ser Val Glu Gln Arg Glu
            20                  25                  30          
Ile Lys Gly Leu Arg Asn Lys Pro Lys Lys Thr Ala His Val Lys Pro
        35                  40                  45              
Asp Leu Ile Asp Val Asp Leu Val Arg Gly Ser Ala Phe Ala Lys Ala
    50                  55                  60                  
Lys Pro Glu Ser Pro Trp Thr Ser Leu Thr Arg Lys Gly Ile Val Arg
65                  70                  75                  80  
Val Val Phe Phe Pro Phe Phe Phe Arg Trp Trp Leu Gln Val Thr Ser
                85                  90                  95      
Lys Val Ile Phe Phe Trp Leu Leu Val Leu Tyr Leu Leu Gln Val Ala
            100                 105                 110         
Ala Ile Val Leu Phe Cys Ser Thr Ser Ser Pro His Ser Ile Pro Leu
        115                 120                 125             
Thr Glu Val Ile Gly Pro Ile Trp Leu Met Leu Leu Leu Gly Thr Val
    130                 135                 140                 
His Cys Gln Ile Val Ser Thr Arg Thr Pro Lys Pro Pro Leu Ser Thr
145                 150                 155                 160 
Gly Gly Lys Arg Arg Arg Lys Leu Arg Lys Ala Ala His Leu Glu Val
                165                 170                 175     
His Arg Glu Gly Asp Gly Ser Ser Thr Thr Asp Asn Thr Gln Glu Gly
            180                 185                 190         
Ala Val Gln Asn His Gly Thr Ser Thr Ser His Ser Val Gly Thr Val
        195                 200                 205             
Phe Arg Asp Leu Trp His Ala Ala Phe Phe Leu Ser Gly Ser Lys Lys
    210                 215                 220                 
Ala Lys Asn Ser Ile Asp Lys Ser Thr Glu Thr Asp Asn Gly Tyr Val
225                 230                 235                 240 
Ser Leu Asp Gly Lys Lys Thr Val Lys Ser Gly Glu Asp Gly Ile Gln
                245                 250                 255     
Asn His Glu Pro Gln Cys Glu Thr Ile Arg Pro Glu Glu Thr Ala Trp
            260                 265                 270         
Asn Thr Gly Thr Leu Arg Asn Gly Pro Ser Lys Asp Thr Gln Arg Thr
        275                 280                 285             
Ile Thr Asn Val Ser Asp Glu Val Ser Ser Glu Glu Gly Pro Glu Thr
    290                 295                 300                 
Gly Tyr Ser Leu Arg Arg His Val Asp Arg Thr Ser Glu Gly Val Leu
305                 310                 315                 320 
Arg Asn Arg Lys Ser His His Tyr Lys Lys His Tyr Pro Asn Glu Asp
                325                 330                 335     
Ala Pro Lys Ser Gly Thr Ser Cys Ser Ser Arg Cys Ser Ser Ser Arg
            340                 345                 350         
Gln Asp Ser Glu Ser Ala Arg Pro Glu Ser Glu Thr Glu Asp Val Leu
        355                 360                 365             
Trp Glu Asp Leu Leu His Cys Ala Glu Cys His Ser Ser Cys Thr Ser
    370                 375                 380                 
Glu Thr Asp Val Glu Asn His Gln Ile Asn Pro Cys Val Lys Lys Glu
385                 390                 395                 400 
Tyr Arg Asp Asp Pro Phe His Gln Ser His Leu Pro Trp Leu His Ser
                405                 410                 415     
Ser His Pro Gly Leu Glu Lys Ile Ser Ala Ile Val Trp Glu Gly Asn
            420                 425                 430         
Asp Cys Lys Lys Ala Asp Met Ser Val Leu Glu Ile Ser Gly Met Ile
        435                 440                 445             
Met Asn Arg Val Asn Ser His Ile Pro Gly Ile Gly Tyr Gln Ile Phe
    450                 455                 460                 
Gly Asn Ala Val Ser Leu Ile Leu Gly Leu Thr Pro Phe Val Phe Arg
465                 470                 475                 480 
Leu Ser Gln Ala Thr Asp Leu Glu Gln Leu Thr Ala His Ser Ala Ser
                485                 490                 495     
Glu Leu Tyr Val Ile Ala Phe Gly Ser Asn Glu Asp Val Ile Val Leu
            500                 505                 510         
Ser Met Val Ile Ile Ser Phe Val Val Arg Val Ser Leu Val Trp Ile
        515                 520                 525             
Phe Phe Phe Leu Leu Cys Val Ala Glu Arg Thr Tyr Lys Gln Arg Leu
    530                 535                 540                 
Leu Phe Ala Lys Leu Phe Gly His Leu Thr Ser Ala Arg Arg Ala Arg
545                 550                 555                 560 
Lys Ser Glu Val Pro His Phe Arg Leu Lys Lys Val Gln Asn Ile Lys
                565                 570                 575     
Met Trp Leu Ser Leu Arg Ser Tyr Leu Lys Arg Arg Gly Pro Gln Arg
            580                 585                 590         
Ser Val Asp Val Ile Val Ser Ser Ala Phe Leu Leu Thr Ile Ser Val
        595                 600                 605             
Val Phe Ile Cys Cys Ala Gln Ile Asn Leu Tyr Leu Lys Met Glu Lys
    610                 615                 620                 
Lys Pro Asn Lys Lys Glu Glu Leu Thr Leu Val Asn Asn Val Leu Lys
625                 630                 635                 640 
Leu Ala Thr Lys Leu Leu Lys Glu Leu Asp Ser Pro Phe Arg Leu Tyr
                645                 650                 655     
Gly Leu Thr Met Asn Pro Leu Leu Tyr Asn Ile Thr Gln Val Val Ile
            660                 665                 670         
Leu Ser Ala Val Ser Gly Val Ile Ser Asp Leu Leu Gly Phe Asn Leu
        675                 680                 685             
Lys Leu Trp Lys Ile Lys Ser
    690                 695 


<210> 9194
<211> 227
<212> PRT
<213> Homo sapiens

<400> 9194
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys
 1               5                  10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Val Arg Thr Lys
            180                 185                 190         
Pro Leu Val Cys Pro Phe Ser Leu Ala Ser Gly Gln Arg Ser Pro Thr
        195                 200                 205             
Ala Leu Leu Leu Tyr Leu Phe Leu Leu Cys Trp Val Ile Val Gly Asp
    210                 215                 220                 
Val Asp Ser
225         


<210> 9195
<211> 233
<212> PRT
<213> Homo sapiens

<400> 9195
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys
 1               5                  10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val
            180                 185                 190         
Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu
        195                 200                 205             
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val
    210                 215                 220                 
Leu Leu Gly Ser Leu Phe Ser Arg Lys
225                 230             


<210> 9196
<211> 170
<212> PRT
<213> Homo sapiens

<400> 9196
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys
 1               5                  10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Asp Thr Phe
        115                 120                 125             
Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln
    130                 135                 140                 
Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val
145                 150                 155                 160 
Val Leu Leu Gly Ser Leu Phe Ser Arg Lys
                165                 170 


<210> 9197
<211> 428
<212> PRT
<213> Homo sapiens

<400> 9197
Met Asp Val Val Asp Ser Leu Leu Val Asn Gly Ser Asn Ile Thr Pro
 1               5                  10                  15      
Pro Cys Glu Leu Gly Leu Glu Asn Glu Thr Leu Phe Cys Leu Asp Gln
            20                  25                  30          
Pro Arg Pro Ser Lys Glu Trp Gln Pro Ala Val Gln Ile Leu Leu Tyr
        35                  40                  45              
Ser Leu Ile Phe Leu Leu Ser Val Leu Gly Asn Thr Leu Val Ile Thr
    50                  55                  60                  
Val Leu Ile Arg Asn Lys Arg Met Arg Thr Val Thr Asn Ile Phe Leu
65                  70                  75                  80  
Leu Ser Leu Ala Val Ser Asp Leu Met Leu Cys Leu Phe Cys Met Pro
                85                  90                  95      
Phe Asn Leu Ile Pro Asn Leu Leu Lys Asp Phe Ile Phe Gly Ser Ala
            100                 105                 110         
Val Cys Lys Thr Thr Thr Tyr Phe Met Gly Thr Ser Val Ser Val Ser
        115                 120                 125             
Thr Phe Asn Leu Val Ala Ile Ser Leu Glu Arg Tyr Gly Ala Ile Cys
    130                 135                 140                 
Lys Pro Leu Gln Ser Arg Val Trp Gln Thr Lys Ser His Ala Leu Lys
145                 150                 155                 160 
Val Ile Ala Ala Thr Trp Cys Leu Ser Phe Thr Ile Met Thr Pro Tyr
                165                 170                 175     
Pro Ile Tyr Ser Asn Leu Val Pro Phe Thr Lys Asn Asn Asn Gln Thr
            180                 185                 190         
Ala Asn Met Cys Arg Phe Leu Leu Pro Asn Asp Val Met Gln Gln Ser
        195                 200                 205             
Trp His Thr Phe Leu Leu Leu Ile Leu Phe Leu Ile Pro Gly Ile Val
    210                 215                 220                 
Met Met Val Ala Tyr Gly Leu Ile Ser Leu Glu Leu Tyr Gln Gly Ile
225                 230                 235                 240 
Lys Phe Glu Ala Ser Gln Lys Lys Ser Ala Lys Glu Arg Lys Pro Ser
                245                 250                 255     
Thr Thr Ser Ser Gly Lys Tyr Glu Asp Ser Asp Gly Cys Tyr Leu Gln
            260                 265                 270         
Lys Thr Arg Pro Pro Arg Lys Leu Glu Leu Arg Gln Leu Ser Thr Gly
        275                 280                 285             
Ser Ser Ser Arg Ala Asn Arg Ile Arg Ser Asn Ser Ser Ala Ala Asn
    290                 295                 300                 
Leu Met Ala Lys Lys Arg Val Ile Arg Met Leu Ile Val Ile Val Val
305                 310                 315                 320 
Leu Phe Phe Leu Cys Trp Met Pro Ile Phe Ser Ala Asn Ala Trp Arg
                325                 330                 335     
Ala Tyr Asp Thr Ala Ser Ala Glu Arg Arg Leu Ser Gly Thr Pro Ile
            340                 345                 350         
Ser Phe Ile Leu Leu Leu Ser Tyr Thr Ser Ser Cys Val Asn Pro Ile
        355                 360                 365             
Ile Tyr Cys Phe Met Asn Lys Arg Phe Arg Leu Gly Phe Met Ala Thr
    370                 375                 380                 
Phe Pro Cys Cys Pro Asn Pro Gly Pro Pro Gly Ala Arg Gly Glu Val
385                 390                 395                 400 
Gly Glu Glu Glu Glu Gly Gly Thr Thr Gly Ala Ser Leu Ser Arg Phe
                405                 410                 415     
Ser Tyr Ser His Met Ser Ala Ser Val Pro Pro Gln
            420                 425             


<210> 9198
<211> 581
<212> PRT
<213> Homo sapiens

<400> 9198
Met Pro Ala Pro Arg Ala Arg Glu Gln Pro Arg Val Pro Gly Glu Arg
 1               5                  10                  15      
Gln Pro Leu Leu Pro Arg Gly Ala Arg Gly Pro Arg Arg Trp Arg Arg
            20                  25                  30          
Ala Ala Gly Ala Ala Val Leu Leu Val Glu Met Leu Glu Arg Ala Ala
        35                  40                  45              
Phe Phe Gly Val Thr Ala Asn Leu Val Leu Tyr Leu Asn Ser Thr Asn
    50                  55                  60                  
Phe Asn Trp Thr Gly Glu Gln Ala Thr Arg Ala Ala Leu Val Phe Leu
65                  70                  75                  80  
Gly Ala Ser Tyr Leu Leu Ala Pro Val Gly Gly Trp Leu Ala Asp Val
                85                  90                  95      
Tyr Leu Gly Arg Tyr Arg Ala Val Ala Leu Ser Leu Leu Leu Tyr Leu
            100                 105                 110         
Ala Ala Ser Gly Leu Leu Pro Ala Thr Ala Phe Pro Asp Gly Arg Ser
        115                 120                 125             
Ser Phe Cys Gly Glu Met Pro Ala Ser Pro Leu Gly Pro Ala Cys Pro
    130                 135                 140                 
Ser Ala Gly Cys Pro Arg Ser Ser Pro Ser Pro Tyr Cys Ala Pro Val
145                 150                 155                 160 
Leu Tyr Ala Gly Leu Leu Leu Leu Gly Leu Ala Ala Ser Ser Val Arg
                165                 170                 175     
Ser Asn Leu Thr Ser Phe Gly Ala Asp Gln Val Met Asp Leu Gly Arg
            180                 185                 190         
Asp Ala Thr Arg Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu
        195                 200                 205             
Gly Ala Val Leu Ser Leu Leu Val Val Ala Phe Ile Gln Gln Asn Ile
    210                 215                 220                 
Ser Phe Leu Leu Gly Tyr Ser Ile Pro Val Gly Cys Val Gly Leu Ala
225                 230                 235                 240 
Phe Phe Ile Phe Leu Phe Ala Thr Pro Val Phe Ile Thr Lys Pro Pro
                245                 250                 255     
Met Gly Ser Gln Val Ser Ser Met Leu Lys Leu Ala Leu Gln Asn Cys
            260                 265                 270         
Cys Pro Gln Leu Trp Gln Arg His Ser Ala Arg Asp Arg Gln Cys Ala
        275                 280                 285             
Arg Val Leu Ala Asp Glu Arg Ser Pro Gln Pro Gly Ala Ser Pro Gln
    290                 295                 300                 
Glu Asp Ile Ala Asn Phe Gln Val Leu Val Lys Ile Leu Pro Val Met
305                 310                 315                 320 
Val Thr Leu Val Pro Tyr Trp Met Val Tyr Phe Gln Met Gln Ser Thr
                325                 330                 335     
Tyr Val Leu Gln Gly Leu His Leu His Ile Pro Asn Phe Phe Pro Ala
            340                 345                 350         
Asn Pro Ala Asn Ile Ser Val Ala Leu Arg Ala Gln Gly Ser Ser Tyr
        355                 360                 365             
Thr Ile Pro Glu Ala Trp Leu Leu Leu Ala Asn Val Val Val Val Leu
    370                 375                 380                 
Ile Leu Val Pro Leu Lys Asp Arg Leu Ile Asp Pro Leu Leu Leu Arg
385                 390                 395                 400 
Cys Lys Leu Leu Pro Ser Ala Leu Gln Lys Met Ala Leu Gly Met Phe
                405                 410                 415     
Phe Gly Phe Thr Ser Val Ile Val Ala Gly Val Leu Glu Met Glu Arg
            420                 425                 430         
Leu His Tyr Ile His His Asn Glu Thr Val Ser Gln Gln Ile Gly Glu
        435                 440                 445             
Val Leu Tyr Asn Ala Ala Pro Leu Ser Ile Trp Trp Gln Ile Pro Gln
    450                 455                 460                 
Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser Ile Pro Gly Leu
465                 470                 475                 480 
Glu Phe Ala Tyr Ser Glu Ala Pro Arg Ser Met Gln Gly Ala Ile Met
                485                 490                 495     
Gly Ile Phe Phe Cys Leu Ser Gly Val Gly Ser Leu Leu Gly Ser Ser
            500                 505                 510         
Leu Val Ala Leu Leu Ser Leu Pro Gly Gly Trp Leu His Cys Pro Lys
        515                 520                 525             
Asp Phe Gly Asn Ile Asn Asn Cys Arg Met Asp Leu Tyr Phe Phe Leu
    530                 535                 540                 
Leu Ala Gly Ile Gln Ala Val Thr Ala Leu Leu Phe Val Trp Ile Ala
545                 550                 555                 560 
Gly Arg Tyr Glu Arg Ala Ser Gln Gly Pro Ala Ser His Ser Arg Phe
                565                 570                 575     
Ser Arg Asp Arg Gly
            580     


<210> 9199
<211> 581
<212> PRT
<213> Homo sapiens

<400> 9199
Met Pro Ala Pro Arg Ala Arg Glu Gln Pro Arg Val Pro Gly Glu Arg
 1               5                  10                  15      
Gln Pro Leu Leu Pro Arg Gly Ala Arg Gly Pro Arg Arg Trp Arg Arg
            20                  25                  30          
Ala Ala Gly Ala Ala Val Leu Leu Val Glu Met Leu Glu Arg Ala Ala
        35                  40                  45              
Phe Phe Gly Val Thr Ala Asn Leu Val Leu Tyr Leu Asn Ser Thr Asn
    50                  55                  60                  
Phe Asn Trp Thr Gly Glu Gln Ala Thr Arg Ala Ala Leu Val Phe Leu
65                  70                  75                  80  
Gly Ala Ser Tyr Leu Leu Ala Pro Val Gly Gly Trp Leu Ala Asp Val
                85                  90                  95      
Tyr Leu Gly Arg Tyr Arg Ala Val Ala Leu Ser Leu Leu Leu Tyr Leu
            100                 105                 110         
Ala Ala Ser Gly Leu Leu Pro Ala Thr Ala Phe Pro Asp Gly Arg Ser
        115                 120                 125             
Ser Phe Cys Gly Glu Met Pro Ala Ser Pro Leu Gly Pro Ala Cys Pro
    130                 135                 140                 
Ser Ala Gly Cys Pro Arg Ser Ser Pro Ser Pro Tyr Cys Ala Pro Val
145                 150                 155                 160 
Leu Tyr Ala Gly Leu Leu Leu Leu Gly Leu Ala Ala Ser Ser Val Arg
                165                 170                 175     
Ser Asn Leu Thr Ser Phe Gly Ala Asp Gln Val Met Asp Leu Gly Arg
            180                 185                 190         
Asp Ala Thr Arg Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu
        195                 200                 205             
Gly Ala Val Leu Ser Leu Leu Val Val Ala Phe Ile Gln Gln Asn Ile
    210                 215                 220                 
Ser Phe Leu Leu Gly Tyr Ser Ile Pro Val Gly Cys Val Gly Leu Ala
225                 230                 235                 240 
Phe Phe Ile Phe Leu Phe Ala Thr Pro Val Phe Ile Thr Lys Pro Pro
                245                 250                 255     
Met Gly Ser Gln Val Ser Ser Met Leu Lys Leu Ala Leu Gln Asn Cys
            260                 265                 270         
Cys Pro Gln Leu Trp Gln Arg His Ser Ala Arg Asp Arg Gln Cys Ala
        275                 280                 285             
Arg Val Leu Ala Asp Glu Arg Ser Pro Gln Pro Gly Ala Ser Pro Gln
    290                 295                 300                 
Glu Asp Ile Ala Asn Phe Gln Val Leu Val Lys Ile Leu Pro Val Met
305                 310                 315                 320 
Val Thr Leu Val Pro Tyr Trp Met Val Tyr Phe Gln Met Gln Ser Thr
                325                 330                 335     
Tyr Val Leu Gln Gly Leu His Leu His Ile Pro Asn Ile Phe Pro Ala
            340                 345                 350         
Asn Pro Ala Asn Ile Ser Val Ala Leu Arg Ala Gln Gly Ser Ser Tyr
        355                 360                 365             
Thr Ile Pro Glu Ala Trp Leu Leu Leu Ala Asn Val Val Val Val Leu
    370                 375                 380                 
Ile Leu Val Pro Leu Lys Asp Arg Leu Ile Asp Pro Leu Leu Leu Arg
385                 390                 395                 400 
Cys Lys Leu Leu Pro Ser Ala Leu Gln Lys Met Ala Leu Gly Met Phe
                405                 410                 415     
Phe Gly Phe Thr Ser Val Ile Val Ala Gly Val Leu Glu Met Glu Arg
            420                 425                 430         
Leu His Tyr Ile His His Asn Glu Thr Val Ser Gln Gln Ile Gly Glu
        435                 440                 445             
Val Leu Tyr Asn Ala Ala Pro Leu Ser Ile Trp Trp Gln Ile Pro Gln
    450                 455                 460                 
Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser Ile Pro Gly Leu
465                 470                 475                 480 
Glu Phe Ala Tyr Ser Glu Ala Pro Arg Ser Met Gln Gly Ala Ile Met
                485                 490                 495     
Gly Ile Phe Phe Cys Leu Ser Gly Val Gly Ser Leu Leu Gly Ser Ser
            500                 505                 510         
Leu Val Ala Leu Leu Ser Leu Pro Gly Gly Trp Leu His Cys Pro Lys
        515                 520                 525             
Asp Phe Gly Asn Ile Asn Asn Cys Arg Met Asp Leu Tyr Phe Phe Leu
    530                 535                 540                 
Leu Ala Gly Ile Gln Ala Val Thr Ala Leu Leu Phe Val Trp Ile Ala
545                 550                 555                 560 
Gly Arg Tyr Glu Arg Ala Ser Gln Gly Pro Ala Ser His Ser Arg Phe
                565                 570                 575     
Ser Arg Asp Arg Gly
            580     


<210> 9200
<211> 575
<212> PRT
<213> Homo sapiens

<400> 9200
Met Ala Lys Pro Phe Phe Arg Leu Gln Lys Phe Leu Arg Arg Thr Gln
 1               5                  10                  15      
Phe Leu Leu Phe Phe Leu Thr Ala Ala Tyr Leu Met Thr Gly Ser Leu
            20                  25                  30          
Leu Leu Leu Gln Arg Val Arg Val Ala Leu Pro Gln Gly Pro Arg Ala
        35                  40                  45              
Pro Gly Pro Leu Gln Thr Leu Pro Val Ala Ala Val Ala Leu Gly Val
    50                  55                  60                  
Gly Leu Leu Asp Ser Arg Ala Leu His Asp Pro Arg Val Ser Pro Glu
65                  70                  75                  80  
Leu Leu Leu Gly Val Asp Met Leu Gln Ser Pro Leu Thr Arg Pro Arg
                85                  90                  95      
Pro Gly Pro Arg Trp Leu Arg Ser Arg Asn Ser Glu Leu Arg Gln Leu
            100                 105                 110         
Arg Arg Arg Trp Phe His His Phe Met Ser Asp Ser Gln Gly Pro Pro
        115                 120                 125             
Ala Leu Gly Pro Glu Ala Ala Arg Pro Ala Ile His Ser Arg Gly Thr
    130                 135                 140                 
Tyr Ile Gly Cys Phe Ser Asp Asp Gly His Glu Arg Thr Leu Lys Gly
145                 150                 155                 160 
Ala Val Phe Tyr Asp Leu Arg Lys Met Thr Val Ser His Cys Gln Asp
                165                 170                 175     
Ala Cys Ala Glu Arg Ser Tyr Val Tyr Ala Gly Leu Glu Ala Gly Ala
            180                 185                 190         
Glu Cys Tyr Cys Gly Asn Arg Leu Pro Ala Val Ser Val Gly Leu Glu
        195                 200                 205             
Glu Cys Asn Tyr Glu Cys Lys Gly Glu Lys Gly Ser Val Cys Gly Ala
    210                 215                 220                 
Val Asp Arg Leu Ser Val Tyr Arg Val Asp Glu Leu Gln Pro Gly Ser
225                 230                 235                 240 
Arg Lys Arg Arg Thr Ala Thr Tyr Arg Gly Cys Phe Arg Leu Pro Glu
                245                 250                 255     
Asn Ile Thr His Ala Phe Pro Ser Ser Leu Ile Gln Ala Asn Val Thr
            260                 265                 270         
Val Gly Thr Cys Ser Gly Phe Cys Ser Gln Lys Glu Phe Pro Leu Ala
        275                 280                 285             
Ile Leu Arg Gly Trp Glu Cys Tyr Cys Ala Tyr Pro Thr Pro Arg Phe
    290                 295                 300                 
Asn Leu Arg Asp Ala Met Asp Ser Ser Val Cys Gly Gln Asp Pro Glu
305                 310                 315                 320 
Ala Gln Arg Leu Ala Glu Tyr Cys Glu Val Tyr Gln Thr Pro Val Gln
                325                 330                 335     
Asp Thr Arg Cys Thr Asp Arg Arg Phe Leu Pro Asn Lys Ser Lys Val
            340                 345                 350         
Phe Val Ala Leu Ser Ser Phe Pro Gly Ala Gly Asn Thr Trp Ala Arg
        355                 360                 365             
His Leu Ile Glu His Ala Thr Gly Phe Tyr Thr Gly Ser Tyr Tyr Phe
    370                 375                 380                 
Asp Gly Thr Leu Tyr Asn Lys Gly Phe Lys Gly Glu Lys Asp His Trp
385                 390                 395                 400 
Arg Ser Arg Arg Thr Ile Cys Val Lys Thr His Glu Ser Gly Arg Arg
                405                 410                 415     
Glu Ile Glu Met Phe Asp Ser Ala Ile Leu Leu Ile Arg Asn Pro Tyr
            420                 425                 430         
Arg Ser Leu Val Ala Glu Phe Asn Arg Lys Cys Ala Gly His Leu Gly
        435                 440                 445             
Tyr Ala Ala Asp Arg Asn Trp Lys Ser Lys Glu Trp Pro Asp Phe Val
    450                 455                 460                 
Asn Ser Tyr Ala Ser Trp Trp Ser Ser His Val Leu Asp Trp Leu Lys
465                 470                 475                 480 
Tyr Gly Lys Arg Leu Leu Val Val His Tyr Glu Glu Leu Arg Arg Ser
                485                 490                 495     
Leu Val Pro Thr Leu Arg Glu Met Val Ala Phe Leu Asn Val Ser Val
            500                 505                 510         
Ser Glu Glu Arg Leu Leu Cys Val Glu Asn Asn Lys Glu Gly Ser Phe
        515                 520                 525             
Arg Arg Arg Gly Arg Arg Ser His Asp Pro Glu Pro Phe Thr Pro Glu
    530                 535                 540                 
Met Lys Asp Leu Ile Asn Gly Tyr Ile Arg Thr Val Asp Gln Ala Leu
545                 550                 555                 560 
Arg Asp His Asn Trp Thr Gly Leu Pro Arg Glu Tyr Val Pro Arg
                565                 570                 575 


<210> 9201
<211> 468
<212> PRT
<213> Homo sapiens

<400> 9201
Glu Leu Arg Gln Leu Arg Arg Arg Trp Phe His His Phe Met Ser Asp
 1               5                  10                  15      
Ser Gln Gly Pro Pro Ala Leu Gly Pro Glu Ala Ala Arg Pro Ala Ile
            20                  25                  30          
His Ser Arg Gly Thr Tyr Ile Gly Cys Phe Ser Asp Asp Gly His Glu
        35                  40                  45              
Arg Thr Leu Lys Gly Ala Val Phe Tyr Asp Leu Arg Lys Met Thr Val
    50                  55                  60                  
Ser His Cys Gln Asp Ala Cys Ala Glu Arg Ser Tyr Val Tyr Ala Gly
65                  70                  75                  80  
Leu Glu Ala Gly Ala Glu Cys Tyr Cys Gly Asn Arg Leu Pro Ala Val
                85                  90                  95      
Ser Val Gly Leu Glu Glu Cys Asn His Glu Cys Lys Gly Glu Lys Gly
            100                 105                 110         
Ser Val Cys Gly Ala Val Asp Arg Leu Ser Val Tyr Arg Val Asp Glu
        115                 120                 125             
Leu Gln Pro Gly Ser Arg Lys Arg Arg Thr Ala Thr Tyr Arg Gly Cys
    130                 135                 140                 
Phe Arg Leu Pro Glu Asn Ile Thr His Ala Phe Pro Ser Ser Leu Ile
145                 150                 155                 160 
Gln Ala Asn Val Thr Val Gly Thr Cys Ser Gly Phe Cys Ser Gln Lys
                165                 170                 175     
Glu Phe Pro Leu Ala Ile Leu Arg Gly Trp Glu Cys Tyr Cys Ala Tyr
            180                 185                 190         
Pro Thr Pro Arg Phe Asn Leu Arg Asp Ala Met Asp Ser Ser Val Cys
        195                 200                 205             
Gly Gln Asp Pro Glu Ala Gln Arg Leu Ala Glu Tyr Cys Glu Val Tyr
    210                 215                 220                 
Gln Thr Pro Val Gln Asp Thr Arg Cys Thr Asp Arg Arg Phe Leu Pro
225                 230                 235                 240 
Asn Lys Ser Lys Val Phe Val Ala Leu Ser Ser Phe Pro Gly Ala Gly
                245                 250                 255     
Asn Thr Trp Ala Arg His Leu Ile Glu His Ala Thr Gly Phe Tyr Thr
            260                 265                 270         
Gly Ser Tyr Tyr Phe Asp Gly Thr Leu Tyr Asn Lys Gly Phe Lys Gly
        275                 280                 285             
Glu Lys Asp His Trp Arg Ser Arg Arg Thr Ile Cys Val Lys Thr His
    290                 295                 300                 
Glu Ser Gly Arg Arg Glu Ile Glu Met Phe Asp Ser Ala Ile Leu Leu
305                 310                 315                 320 
Ile Arg Asn Pro Tyr Arg Ser Leu Val Ala Glu Phe Asn Arg Lys Cys
                325                 330                 335     
Ala Gly His Leu Gly Tyr Ala Ala Asp Arg Asn Trp Lys Ser Lys Glu
            340                 345                 350         
Trp Pro Asp Phe Val Asn Ser Tyr Ala Ser Trp Trp Ser Ser His Val
        355                 360                 365             
Leu Asp Trp Leu Lys Tyr Gly Lys Arg Leu Leu Val Val His Tyr Glu
    370                 375                 380                 
Glu Leu Arg Arg Ser Leu Val Pro Thr Leu Arg Glu Met Val Ala Phe
385                 390                 395                 400 
Leu Asn Val Ser Val Ser Glu Glu Arg Leu Leu Cys Val Glu Asn Asn
                405                 410                 415     
Lys Glu Gly Ser Phe Arg Arg Arg Gly Arg Arg Ser His Asp Pro Glu
            420                 425                 430         
Pro Phe Thr Pro Glu Met Lys Asp Leu Ile Asn Gly Tyr Ile Arg Thr
        435                 440                 445             
Val Asp Gln Ala Leu Arg Asp His Asn Trp Thr Gly Leu Pro Arg Glu
    450                 455                 460                 
Tyr Val Pro Arg
465             


<210> 9202
<211> 389
<212> PRT
<213> Homo sapiens

<400> 9202
Met Glu Asp Ser Pro Thr Met Val Arg Val Asp Ser Pro Thr Met Val
 1               5                  10                  15      
Arg Gly Glu Asn Gln Val Ser Pro Cys Gln Gly Arg Arg Cys Phe Pro
            20                  25                  30          
Lys Ala Leu Gly Tyr Val Thr Gly Asp Met Lys Glu Leu Ala Asn Gln
        35                  40                  45              
Leu Lys Asp Lys Pro Val Val Leu Gln Phe Ile Asp Trp Ile Leu Arg
    50                  55                  60                  
Gly Ile Ser Gln Val Val Phe Val Asn Asn Pro Val Ser Gly Ile Leu
65                  70                  75                  80  
Ile Leu Val Gly Leu Leu Val Gln Asn Pro Trp Trp Ala Leu Thr Gly
                85                  90                  95      
Trp Leu Gly Thr Val Val Ser Thr Leu Met Ala Leu Leu Leu Ser Gln
            100                 105                 110         
Asp Arg Ser Leu Ile Ala Ser Gly Leu Tyr Gly Tyr Asn Ala Thr Leu
        115                 120                 125             
Val Gly Val Leu Met Ala Val Phe Ser Asp Lys Gly Asp Tyr Phe Trp
    130                 135                 140                 
Trp Leu Leu Leu Pro Val Cys Ala Met Ser Met Thr Cys Pro Ile Phe
145                 150                 155                 160 
Ser Ser Ala Leu Asn Ser Met Leu Ser Lys Trp Asp Leu Pro Val Phe
                165                 170                 175     
Thr Leu Pro Phe Asn Met Ala Leu Ser Met Tyr Leu Ser Ala Thr Gly
            180                 185                 190         
His Tyr Asn Pro Phe Phe Pro Ala Lys Leu Val Ile Pro Ile Thr Thr
        195                 200                 205             
Ala Pro Asn Ile Ser Trp Ser Asp Leu Ser Ala Leu Glu Leu Leu Lys
    210                 215                 220                 
Ser Ile Pro Val Gly Val Gly Gln Ile Tyr Gly Cys Asp Asn Pro Trp
225                 230                 235                 240 
Thr Gly Gly Ile Phe Leu Gly Ala Ile Leu Leu Ser Ser Pro Leu Met
                245                 250                 255     
Cys Leu His Ala Ala Ile Gly Ser Leu Leu Gly Ile Ala Ala Gly Leu
            260                 265                 270         
Ser Leu Ser Ala Pro Phe Glu Asp Ile Tyr Phe Gly Leu Trp Gly Phe
        275                 280                 285             
Asn Ser Ser Leu Ala Cys Ile Ala Met Gly Gly Met Phe Met Ala Leu
    290                 295                 300                 
Thr Trp Gln Thr His Leu Leu Ala Leu Gly Cys Ala Leu Phe Thr Ala
305                 310                 315                 320 
Tyr Leu Gly Val Gly Met Ala Asn Phe Met Ala Glu Val Gly Leu Pro
                325                 330                 335     
Ala Cys Thr Trp Pro Phe Cys Leu Ala Thr Leu Leu Phe Leu Ile Met
            340                 345                 350         
Thr Thr Lys Asn Ser Asn Ile Tyr Lys Met Pro Leu Ser Lys Val Thr
        355                 360                 365             
Tyr Pro Glu Glu Asn Arg Ile Phe Tyr Leu Gln Ala Lys Lys Arg Met
    370                 375                 380                 
Val Glu Ser Pro Leu
385                 


<210> 9203
<211> 4302
<212> PRT
<213> Homo sapiens

<400> 9203
Met Pro Pro Ala Ala Pro Ala Arg Leu Ala Leu Ala Leu Gly Leu Gly
 1               5                  10                  15      
Leu Trp Leu Gly Ala Leu Ala Gly Gly Pro Gly Arg Gly Cys Gly Pro
            20                  25                  30          
Cys Glu Pro Pro Cys Leu Cys Gly Pro Ala Pro Gly Ala Ala Cys Arg
        35                  40                  45              
Val Asn Cys Ser Gly Arg Gly Leu Arg Thr Leu Gly Pro Ala Leu Arg
    50                  55                  60                  
Ile Pro Ala Asp Ala Thr Ala Leu Asp Val Ser His Asn Leu Leu Arg
65                  70                  75                  80  
Ala Leu Asp Val Gly Leu Leu Ala Asn Leu Ser Ala Leu Ala Glu Leu
                85                  90                  95      
Asp Ile Ser Asn Asn Lys Ile Ser Thr Leu Glu Glu Gly Ile Phe Ala
            100                 105                 110         
Asn Leu Phe Asn Leu Ser Glu Ile Asn Leu Ser Gly Asn Pro Phe Glu
        115                 120                 125             
Cys Asp Cys Gly Leu Ala Trp Leu Pro Arg Trp Ala Glu Glu Gln Gln
    130                 135                 140                 
Val Arg Val Val Gln Pro Glu Ala Ala Thr Cys Ala Gly Pro Gly Ser
145                 150                 155                 160 
Leu Ala Gly Gln Pro Leu Leu Gly Ile Pro Leu Leu Asp Ser Gly Cys
                165                 170                 175     
Gly Glu Glu Tyr Val Ala Cys Leu Pro Asp Asn Ser Ser Gly Thr Val
            180                 185                 190         
Ala Ala Val Ser Phe Ser Ala Ala His Glu Gly Leu Leu Gln Pro Glu
        195                 200                 205             
Ala Cys Ser Ala Phe Cys Phe Ser Thr Gly Gln Gly Leu Ala Ala Leu
    210                 215                 220                 
Ser Glu Gln Gly Trp Cys Leu Cys Gly Ala Ala Gln Pro Ser Ser Ala
225                 230                 235                 240 
Ser Phe Ala Cys Leu Ser Leu Cys Ser Gly Pro Pro Pro Pro Pro Ala
                245                 250                 255     
Pro Thr Cys Arg Gly Pro Thr Leu Leu Gln His Val Phe Pro Ala Ser
            260                 265                 270         
Pro Gly Ala Thr Leu Val Gly Pro His Gly Pro Leu Ala Ser Gly Gln
        275                 280                 285             
Leu Ala Ala Phe His Ile Ala Ala Pro Leu Pro Val Thr Ala Thr Arg
    290                 295                 300                 
Trp Asp Phe Gly Asp Gly Ser Ala Glu Val Asp Ala Ala Gly Pro Ala
305                 310                 315                 320 
Ala Ser His Arg Tyr Val Leu Pro Gly Arg Tyr His Val Thr Ala Val
                325                 330                 335     
Leu Ala Leu Gly Ala Gly Ser Ala Leu Leu Gly Thr Asp Val Gln Val
            340                 345                 350         
Glu Ala Ala Pro Ala Ala Leu Glu Leu Val Cys Pro Ser Ser Val Gln
        355                 360                 365             
Ser Asp Glu Ser Leu Asp Leu Ser Ile Gln Asn Arg Gly Gly Ser Gly
    370                 375                 380                 
Leu Glu Ala Ala Tyr Ser Ile Val Ala Leu Gly Glu Glu Pro Ala Arg
385                 390                 395                 400 
Ala Val His Pro Leu Cys Pro Ser Asp Thr Glu Ile Phe Pro Gly Asn
                405                 410                 415     
Gly His Cys Tyr Arg Leu Val Val Glu Lys Ala Ala Trp Leu Gln Ala
            420                 425                 430         
Gln Glu Gln Cys Gln Ala Trp Ala Gly Ala Ala Leu Ala Met Val Asp
        435                 440                 445             
Ser Pro Ala Val Gln Arg Phe Leu Val Ser Arg Val Thr Arg Ser Leu
    450                 455                 460                 
Asp Val Trp Ile Gly Phe Ser Thr Val Gln Gly Val Glu Val Gly Pro
465                 470                 475                 480 
Ala Pro Gln Gly Glu Ala Phe Ser Leu Glu Ser Cys Gln Asn Trp Leu
                485                 490                 495     
Pro Gly Glu Pro His Pro Ala Thr Ala Glu His Cys Val Arg Leu Gly
            500                 505                 510         
Pro Thr Gly Trp Cys Asn Thr Asp Leu Cys Ser Ala Pro His Ser Tyr
        515                 520                 525             
Val Cys Glu Leu Gln Pro Gly Gly Pro Val Gln Asp Ala Glu Asn Leu
    530                 535                 540                 
Leu Val Gly Ala Pro Ser Gly Asp Leu Gln Gly Pro Leu Thr Pro Leu
545                 550                 555                 560 
Ala Gln Gln Asp Gly Leu Ser Ala Pro His Glu Pro Val Glu Val Met
                565                 570                 575     
Val Phe Pro Gly Leu Arg Leu Ser Arg Glu Ala Phe Leu Thr Thr Ala
            580                 585                 590         
Glu Phe Gly Thr Gln Glu Leu Arg Arg Pro Ala Gln Leu Arg Leu Gln
        595                 600                 605             
Val Tyr Arg Leu Leu Ser Thr Ala Gly Thr Pro Glu Asn Gly Ser Glu
    610                 615                 620                 
Pro Glu Ser Arg Ser Pro Asp Asn Arg Thr Gln Leu Ala Pro Ala Cys
625                 630                 635                 640 
Met Pro Gly Gly Arg Trp Cys Pro Gly Ala Asn Ile Cys Leu Pro Leu
                645                 650                 655     
Asp Ala Ser Cys His Pro Gln Ala Cys Ala Asn Gly Cys Thr Ser Gly
            660                 665                 670         
Pro Gly Leu Pro Gly Ala Pro Tyr Ala Leu Trp Arg Glu Phe Leu Phe
        675                 680                 685             
Ser Val Ala Ala Gly Pro Pro Ala Gln Tyr Ser Val Thr Leu His Gly
    690                 695                 700                 
Gln Asp Val Leu Met Leu Pro Gly Asp Leu Val Gly Leu Gln His Asp
705                 710                 715                 720 
Ala Gly Pro Gly Ala Leu Leu His Cys Ser Pro Ala Pro Gly His Pro
                725                 730                 735     
Gly Pro Gln Ala Pro Tyr Leu Ser Ala Asn Ala Ser Ser Trp Leu Pro
            740                 745                 750         
His Leu Pro Ala Gln Leu Glu Gly Thr Trp Ala Cys Pro Ala Cys Ala
        755                 760                 765             
Leu Arg Leu Leu Ala Ala Thr Glu Gln Leu Thr Val Leu Leu Gly Leu
    770                 775                 780                 
Arg Pro Asn Pro Gly Leu Arg Met Pro Gly Arg Tyr Glu Val Arg Ala
785                 790                 795                 800 
Glu Val Gly Asn Gly Val Ser Arg His Asn Leu Ser Cys Ser Phe Asp
                805                 810                 815     
Val Val Ser Pro Val Ala Gly Leu Arg Val Ile Tyr Pro Ala Pro Arg
            820                 825                 830         
Asp Gly Arg Leu Tyr Val Pro Thr Asn Gly Ser Ala Leu Val Leu Gln
        835                 840                 845             
Val Asp Ser Gly Ala Asn Ala Thr Ala Thr Ala Arg Trp Pro Gly Gly
    850                 855                 860                 
Ser Val Ser Ala Arg Phe Glu Asn Val Cys Pro Ala Leu Val Ala Thr
865                 870                 875                 880 
Phe Val Pro Gly Cys Pro Trp Glu Thr Asn Asp Thr Leu Phe Ser Val
                885                 890                 895     
Val Ala Leu Pro Trp Leu Ser Glu Gly Glu His Val Val Asp Val Val
            900                 905                 910         
Val Glu Asn Ser Ala Ser Arg Ala Asn Leu Ser Leu Arg Val Thr Ala
        915                 920                 925             
Glu Glu Pro Ile Cys Gly Leu Arg Ala Thr Pro Ser Pro Glu Ala Arg
    930                 935                 940                 
Val Leu Gln Gly Val Leu Val Arg Tyr Ser Pro Val Val Glu Ala Gly
945                 950                 955                 960 
Ser Asp Met Val Phe Arg Trp Thr Ile Asn Asp Lys Gln Ser Leu Thr
                965                 970                 975     
Phe Gln Asn Val Val Phe Asn Val Ile Tyr Gln Ser Ala Ala Val Phe
            980                 985                 990         
Lys Leu Ser Leu Thr Ala Ser Asn His Val Ser Asn Val Thr Val Asn
        995                 1000                1005            
Tyr Asn Val Thr Val Glu Arg Met Asn Arg Met Gln Gly Leu Gln Val
    1010                1015                1020                
Ser Thr Val Pro Ala Val Leu Ser Pro Asn Ala Thr Leu Ala Leu Thr
1025                1030                1035                1040
Ala Gly Val Leu Val Asp Ser Ala Val Glu Val Ala Phe Leu Trp Asn
                1045                1050                1055    
Phe Gly Asp Gly Glu Gln Ala Leu His Gln Phe Gln Pro Pro Tyr Asn
            1060                1065                1070        
Glu Ser Phe Pro Val Pro Asp Pro Ser Val Ala Gln Val Leu Val Glu
        1075                1080                1085            
His Asn Val Met His Thr Tyr Ala Ala Pro Gly Glu Tyr Leu Leu Thr
    1090                1095                1100                
Val Leu Ala Ser Asn Ala Phe Glu Asn Leu Thr Gln Gln Val Pro Val
1105                1110                1115                1120
Ser Val Arg Ala Ser Leu Pro Ser Val Ala Val Gly Val Ser Asp Gly
                1125                1130                1135    
Val Leu Val Ala Gly Arg Pro Val Thr Phe Tyr Pro His Pro Leu Pro
            1140                1145                1150        
Ser Pro Gly Gly Val Leu Tyr Thr Trp Asp Phe Gly Asp Gly Ser Pro
        1155                1160                1165            
Val Leu Thr Gln Ser Gln Pro Ala Ala Asn His Thr Tyr Ala Ser Arg
    1170                1175                1180                
Gly Thr Tyr His Val Arg Leu Glu Val Asn Asn Thr Val Ser Gly Ala
1185                1190                1195                1200
Ala Ala Gln Ala Asp Val Arg Val Phe Glu Glu Leu Arg Gly Leu Ser
                1205                1210                1215    
Val Asp Met Ser Leu Ala Val Glu Gln Gly Ala Pro Val Val Val Ser
            1220                1225                1230        
Ala Ala Val Gln Thr Gly Asp Asn Ile Thr Trp Thr Phe Asp Met Gly
        1235                1240                1245            
Asp Gly Thr Val Leu Ser Gly Pro Glu Ala Thr Val Glu His Val Tyr
    1250                1255                1260                
Leu Arg Ala Gln Asn Cys Thr Val Thr Val Gly Ala Ala Ser Pro Ala
1265                1270                1275                1280
Gly His Leu Ala Arg Ser Leu His Val Leu Val Phe Val Leu Glu Val
                1285                1290                1295    
Leu Arg Val Glu Pro Ala Ala Cys Ile Pro Thr Gln Pro Asp Ala Arg
            1300                1305                1310        
Leu Thr Ala Tyr Val Thr Gly Asn Pro Ala His Tyr Leu Phe Asp Trp
        1315                1320                1325            
Thr Phe Gly Asp Gly Ser Ser Asn Thr Thr Val Arg Gly Cys Pro Thr
    1330                1335                1340                
Val Thr His Asn Phe Thr Arg Ser Gly Thr Phe Pro Leu Ala Leu Val
1345                1350                1355                1360
Leu Ser Ser Arg Val Asn Arg Ala His Tyr Phe Thr Ser Ile Cys Val
                1365                1370                1375    
Glu Pro Glu Val Gly Asn Val Thr Leu Gln Pro Glu Arg Gln Phe Val
            1380                1385                1390        
Gln Leu Gly Asp Glu Ala Trp Leu Val Ala Cys Ala Trp Pro Pro Phe
        1395                1400                1405            
Pro Tyr Arg Tyr Thr Trp Asp Phe Gly Thr Glu Glu Ala Ala Pro Thr
    1410                1415                1420                
Arg Ala Arg Gly Pro Glu Val Thr Phe Ile Tyr Arg Asp Pro Gly Ser
1425                1430                1435                1440
Tyr Leu Val Thr Val Thr Ala Ser Asn Asn Ile Ser Ala Ala Asn Asp
                1445                1450                1455    
Ser Ala Leu Val Glu Val Gln Glu Pro Val Leu Val Thr Ser Ile Lys
            1460                1465                1470        
Val Asn Gly Ser Leu Gly Leu Glu Leu Gln Gln Pro Tyr Leu Phe Ser
        1475                1480                1485            
Ala Val Gly Arg Gly Arg Pro Ala Ser Tyr Leu Trp Asp Leu Gly Asp
    1490                1495                1500                
Gly Gly Trp Leu Glu Gly Pro Glu Val Thr His Ala Tyr Asn Ser Thr
1505                1510                1515                1520
Gly Asp Phe Thr Val Arg Val Ala Gly Trp Asn Glu Val Ser Arg Ser
                1525                1530                1535    
Glu Ala Trp Leu Asn Val Thr Val Lys Arg Arg Val Arg Gly Leu Val
            1540                1545                1550        
Val Asn Ala Ser Arg Thr Val Val Pro Leu Asn Gly Ser Val Ser Phe
        1555                1560                1565            
Ser Thr Ser Leu Glu Ala Gly Ser Asp Val Arg Tyr Ser Trp Val Leu
    1570                1575                1580                
Cys Asp Arg Cys Thr Pro Ile Pro Gly Gly Pro Thr Ile Ser Tyr Thr
1585                1590                1595                1600
Phe Arg Ser Val Gly Thr Phe Asn Ile Ile Val Thr Ala Glu Asn Glu
                1605                1610                1615    
Val Gly Ser Ala Gln Asp Ser Ile Phe Val Tyr Val Leu Gln Leu Ile
            1620                1625                1630        
Glu Gly Leu Gln Val Val Gly Gly Gly Arg Tyr Phe Pro Thr Asn His
        1635                1640                1645            
Thr Val Gln Leu Gln Ala Val Val Arg Asp Gly Thr Asn Val Ser Tyr
    1650                1655                1660                
Ser Trp Thr Ala Trp Arg Asp Arg Gly Pro Ala Leu Ala Gly Ser Gly
1665                1670                1675                1680
Lys Gly Phe Ser Leu Thr Val Leu Glu Ala Gly Thr Tyr His Val Gln
                1685                1690                1695    
Leu Arg Ala Thr Asn Met Leu Gly Ser Ala Trp Ala Asp Cys Thr Met
            1700                1705                1710        
Asp Phe Val Glu Pro Val Gly Trp Leu Met Val Thr Ala Ser Pro Asn
        1715                1720                1725            
Pro Ala Ala Val Asn Thr Ser Val Thr Leu Ser Ala Glu Leu Ala Gly
    1730                1735                1740                
Gly Ser Gly Val Val Tyr Thr Trp Ser Leu Glu Glu Gly Leu Ser Trp
1745                1750                1755                1760
Glu Thr Ser Glu Pro Phe Thr Thr His Ser Phe Pro Thr Pro Gly Leu
                1765                1770                1775    
His Leu Val Thr Met Thr Ala Gly Asn Pro Leu Gly Ser Ala Asn Ala
            1780                1785                1790        
Thr Val Glu Val Asp Val Gln Val Pro Val Ser Gly Leu Ser Ile Arg
        1795                1800                1805            
Ala Ser Glu Pro Gly Gly Ser Phe Val Ala Ala Gly Ser Ser Val Pro
    1810                1815                1820                
Phe Trp Gly Gln Leu Ala Thr Gly Thr Asn Val Ser Trp Cys Trp Ala
1825                1830                1835                1840
Val Pro Gly Gly Ser Ser Lys Arg Gly Pro His Val Thr Met Val Phe
                1845                1850                1855    
Pro Asp Ala Gly Thr Phe Ser Ile Arg Leu Asn Ala Ser Asn Ala Val
            1860                1865                1870        
Ser Trp Val Ser Ala Thr Tyr Asn Leu Thr Ala Glu Glu Pro Ile Val
        1875                1880                1885            
Gly Leu Val Leu Trp Ala Ser Ser Lys Val Val Ala Pro Gly Gln Leu
    1890                1895                1900                
Val His Phe Gln Ile Leu Leu Ala Ala Gly Ser Ala Val Thr Phe Arg
1905                1910                1915                1920
Leu Gln Val Gly Gly Ala Asn Pro Glu Val Leu Pro Gly Pro Arg Phe
                1925                1930                1935    
Ser His Ser Phe Pro Arg Val Gly Asp His Val Val Ser Val Arg Gly
            1940                1945                1950        
Lys Asn His Val Ser Trp Ala Gln Ala Gln Val Arg Ile Val Val Leu
        1955                1960                1965            
Glu Ala Val Ser Gly Leu Gln Met Pro Asn Cys Cys Glu Pro Gly Ile
    1970                1975                1980                
Ala Thr Gly Thr Glu Arg Asn Phe Thr Ala Arg Val Gln Arg Gly Ser
1985                1990                1995                2000
Arg Val Ala Tyr Ala Trp Tyr Phe Ser Leu Gln Lys Val Gln Gly Asp
                2005                2010                2015    
Ser Leu Val Ile Leu Ser Gly Arg Asp Val Thr Tyr Thr Pro Val Ala
            2020                2025                2030        
Ala Gly Leu Leu Glu Ile Gln Val Arg Ala Phe Asn Ala Leu Gly Ser
        2035                2040                2045            
Glu Asn Arg Thr Leu Val Leu Glu Val Gln Asp Ala Val Gln Tyr Val
    2050                2055                2060                
Ala Leu Gln Ser Gly Pro Cys Phe Thr Asn Arg Ser Ala Gln Phe Glu
2065                2070                2075                2080
Ala Ala Thr Ser Pro Ser Pro Arg Arg Val Ala Tyr His Trp Asp Phe
                2085                2090                2095    
Gly Asp Gly Ser Pro Gly Gln Asp Thr Asp Glu Pro Arg Ala Glu His
            2100                2105                2110        
Ser Tyr Leu Arg Pro Gly Asp Tyr Arg Val Gln Val Asn Ala Ser Asn
        2115                2120                2125            
Leu Val Ser Phe Phe Val Ala Gln Ala Thr Val Thr Val Gln Val Leu
    2130                2135                2140                
Ala Cys Arg Glu Pro Glu Val Asp Val Val Leu Pro Leu Gln Val Leu
2145                2150                2155                2160
Met Arg Arg Ser Gln Arg Asn Tyr Leu Glu Ala His Val Asp Leu Arg
                2165                2170                2175    
Asp Cys Val Thr Tyr Gln Thr Glu Tyr Arg Trp Glu Val Tyr Arg Thr
            2180                2185                2190        
Ala Ser Cys Gln Arg Pro Gly Arg Pro Ala Arg Val Ala Leu Pro Gly
        2195                2200                2205            
Val Asp Val Ser Arg Pro Arg Leu Val Leu Pro Arg Leu Ala Leu Pro
    2210                2215                2220                
Val Gly His Tyr Cys Phe Val Phe Val Val Ser Phe Gly Asp Thr Pro
2225                2230                2235                2240
Leu Thr Gln Ser Ile Gln Ala Asn Val Thr Val Ala Pro Glu Arg Leu
                2245                2250                2255    
Val Pro Ile Ile Glu Gly Gly Ser Tyr Arg Val Trp Ser Asp Thr Arg
            2260                2265                2270        
Asp Leu Val Leu Asp Gly Ser Glu Ser Tyr Asp Pro Asn Leu Glu Asp
        2275                2280                2285            
Gly Asp Gln Thr Pro Leu Ser Phe His Trp Ala Cys Val Ala Ser Thr
    2290                2295                2300                
Gln Arg Glu Ala Gly Gly Cys Ala Leu Asn Phe Gly Pro Arg Gly Ser
2305                2310                2315                2320
Ser Thr Val Thr Ile Pro Arg Glu Arg Leu Ala Ala Gly Val Glu Tyr
                2325                2330                2335    
Thr Phe Ser Leu Thr Val Trp Lys Ala Gly Arg Lys Glu Glu Ala Thr
            2340                2345                2350        
Asn Gln Thr Val Leu Ile Arg Ser Gly Arg Val Pro Ile Val Ser Leu
        2355                2360                2365            
Glu Cys Val Ser Cys Lys Ala Gln Ala Val Tyr Glu Val Ser Arg Ser
    2370                2375                2380                
Ser Tyr Val Tyr Leu Glu Gly Arg Cys Leu Asn Cys Ser Ser Gly Ser
2385                2390                2395                2400
Lys Arg Gly Arg Trp Ala Ala Arg Thr Phe Ser Asn Lys Thr Leu Val
                2405                2410                2415    
Leu Asp Glu Thr Thr Thr Ser Thr Gly Ser Ala Gly Met Arg Leu Val
            2420                2425                2430        
Leu Arg Arg Gly Val Leu Arg Asp Gly Glu Gly Tyr Thr Phe Thr Leu
        2435                2440                2445            
Thr Val Leu Gly Arg Ser Gly Glu Glu Glu Gly Cys Ala Ser Ile Arg
    2450                2455                2460                
Leu Ser Pro Asn Arg Pro Pro Leu Gly Gly Ser Cys Arg Leu Phe Pro
2465                2470                2475                2480
Leu Gly Ala Val His Ala Leu Thr Thr Lys Val His Phe Glu Cys Thr
                2485                2490                2495    
Gly Trp His Asp Ala Glu Asp Ala Gly Ala Pro Leu Val Tyr Ala Leu
            2500                2505                2510        
Leu Leu Arg Arg Cys Arg Gln Gly His Cys Glu Glu Phe Cys Val Tyr
        2515                2520                2525            
Lys Gly Ser Leu Ser Ser Tyr Gly Ala Val Leu Pro Pro Gly Phe Arg
    2530                2535                2540                
Pro His Phe Glu Val Gly Leu Ala Val Val Val Gln Asp Gln Leu Gly
2545                2550                2555                2560
Ala Ala Val Val Ala Leu Asn Arg Ser Leu Ala Ile Thr Leu Pro Glu
                2565                2570                2575    
Pro Asn Gly Ser Ala Thr Gly Leu Thr Val Trp Leu His Gly Leu Thr
            2580                2585                2590        
Ala Ser Val Leu Pro Gly Leu Leu Arg Gln Ala Asp Pro Gln His Val
        2595                2600                2605            
Ile Glu Tyr Ser Leu Ala Leu Val Thr Val Leu Asn Glu Tyr Glu Arg
    2610                2615                2620                
Ala Leu Asp Val Ala Ala Glu Pro Lys His Glu Arg Gln His Arg Ala
2625                2630                2635                2640
Gln Ile Arg Lys Asn Ile Thr Glu Thr Leu Val Ser Leu Arg Val His
                2645                2650                2655    
Thr Val Asp Asp Ile Gln Gln Ile Ala Ala Ala Leu Ala Gln Cys Met
            2660                2665                2670        
Gly Pro Ser Arg Glu Leu Val Cys Arg Ser Cys Leu Lys Gln Thr Leu
        2675                2680                2685            
His Lys Leu Glu Ala Met Met Leu Ile Leu Gln Ala Glu Thr Thr Ala
    2690                2695                2700                
Gly Thr Val Thr Pro Thr Ala Ile Gly Asp Ser Ile Leu Asn Ile Thr
2705                2710                2715                2720
Gly Asp Leu Ile His Leu Ala Ser Ser Asp Val Arg Ala Pro Gln Pro
                2725                2730                2735    
Ser Glu Leu Gly Ala Glu Ser Pro Ser Arg Met Val Ala Ser Gln Ala
            2740                2745                2750        
Tyr Asn Leu Thr Ser Ala Leu Met Arg Ile Leu Met Arg Ser Arg Val
        2755                2760                2765            
Leu Asn Glu Glu Pro Leu Thr Leu Ala Gly Glu Glu Ile Val Ala Gln
    2770                2775                2780                
Gly Lys Arg Ser Asp Pro Arg Ser Leu Leu Cys Tyr Gly Gly Ala Pro
2785                2790                2795                2800
Gly Pro Gly Cys His Phe Ser Ile Pro Glu Ala Phe Ser Gly Ala Leu
                2805                2810                2815    
Ala Asn Leu Ser Asp Val Val Gln Leu Ile Phe Leu Val Asp Ser Asn
            2820                2825                2830        
Pro Phe Pro Phe Gly Tyr Ile Ser Asn Tyr Thr Val Ser Thr Lys Val
        2835                2840                2845            
Ala Ser Met Ala Phe Gln Thr Gln Ala Gly Ala Gln Ile Pro Ile Glu
    2850                2855                2860                
Arg Leu Ala Ser Glu Arg Ala Ile Thr Val Lys Val Pro Asn Asn Ser
2865                2870                2875                2880
Asp Trp Ala Ala Arg Gly His Arg Ser Ser Ala Asn Ser Ala Asn Ser
                2885                2890                2895    
Val Val Val Gln Pro Gln Ala Ser Val Gly Ala Val Val Thr Leu Asp
            2900                2905                2910        
Ser Ser Asn Pro Ala Ala Gly Leu His Leu Gln Leu Asn Tyr Thr Leu
        2915                2920                2925            
Leu Asp Gly His Tyr Leu Ser Glu Glu Pro Glu Pro Tyr Leu Ala Val
    2930                2935                2940                
Tyr Leu His Ser Glu Pro Arg Pro Asn Glu His Asn Cys Ser Ala Ser
2945                2950                2955                2960
Arg Arg Ile Arg Pro Glu Ser Leu Gln Gly Ala Asp His Arg Pro Tyr
                2965                2970                2975    
Thr Phe Phe Ile Ser Pro Gly Ser Arg Asp Pro Ala Gly Ser Tyr His
            2980                2985                2990        
Leu Asn Leu Ser Ser His Phe Arg Trp Ser Ala Leu Gln Val Ser Val
        2995                3000                3005            
Gly Leu Tyr Thr Ser Leu Cys Gln Tyr Phe Ser Glu Glu Asp Met Val
    3010                3015                3020                
Trp Arg Thr Glu Gly Leu Leu Pro Leu Glu Glu Thr Ser Pro Arg Gln
3025                3030                3035                3040
Ala Val Cys Leu Thr Arg His Leu Thr Ala Phe Gly Ala Ser Leu Phe
                3045                3050                3055    
Val Pro Pro Ser His Val Arg Phe Val Phe Pro Glu Pro Thr Ala Asp
            3060                3065                3070        
Val Asn Tyr Ile Val Met Leu Thr Cys Ala Val Cys Leu Val Thr Tyr
        3075                3080                3085            
Met Val Met Ala Ala Ile Leu His Lys Leu Asp Gln Leu Asp Ala Ser
    3090                3095                3100                
Arg Gly Arg Ala Ile Pro Phe Cys Gly Gln Arg Gly Arg Phe Lys Tyr
3105                3110                3115                3120
Glu Ile Leu Val Lys Thr Gly Trp Gly Arg Gly Ser Gly Thr Thr Ala
                3125                3130                3135    
His Val Gly Ile Met Leu Tyr Gly Val Asp Ser Arg Ser Gly His Arg
            3140                3145                3150        
His Leu Asp Gly Asp Arg Ala Phe His Arg Asn Ser Leu Asp Ile Phe
        3155                3160                3165            
Arg Ile Ala Thr Pro His Ser Leu Gly Ser Val Trp Lys Ile Arg Val
    3170                3175                3180                
Trp His Asp Asn Lys Gly Leu Ser Pro Ala Trp Phe Leu Gln His Val
3185                3190                3195                3200
Ile Val Arg Asp Leu Gln Thr Ala Arg Ser Ala Phe Phe Leu Val Asn
                3205                3210                3215    
Asp Trp Leu Ser Val Glu Thr Glu Ala Asn Gly Gly Leu Val Glu Lys
            3220                3225                3230        
Glu Val Leu Ala Ala Ser Asp Ala Ala Leu Leu Arg Phe Arg Arg Leu
        3235                3240                3245            
Leu Val Ala Glu Leu Gln Arg Gly Phe Phe Asp Lys His Ile Trp Leu
    3250                3255                3260                
Ser Ile Trp Asp Arg Pro Pro Arg Ser Arg Phe Thr Arg Ile Gln Arg
3265                3270                3275                3280
Ala Thr Cys Cys Val Leu Leu Ile Cys Leu Phe Leu Gly Ala Asn Ala
                3285                3290                3295    
Val Trp Tyr Gly Ala Val Gly Asp Ser Ala Tyr Ser Thr Gly His Val
            3300                3305                3310        
Ser Arg Leu Ser Pro Leu Ser Val Asp Thr Val Ala Val Gly Leu Val
        3315                3320                3325            
Ser Ser Val Val Val Tyr Pro Val Tyr Leu Ala Ile Leu Phe Leu Phe
    3330                3335                3340                
Arg Met Ser Arg Ser Lys Val Ala Gly Ser Pro Ser Pro Thr Pro Ala
3345                3350                3355                3360
Gly Gln Gln Val Leu Asp Ile Asp Ser Cys Leu Asp Ser Ser Val Leu
                3365                3370                3375    
Asp Ser Ser Phe Leu Thr Phe Ser Gly Leu His Ala Glu Ala Phe Val
            3380                3385                3390        
Gly Gln Met Lys Ser Asp Leu Phe Leu Asp Asp Ser Lys Ser Leu Val
        3395                3400                3405            
Cys Trp Pro Ser Gly Glu Gly Thr Leu Ser Trp Pro Asp Leu Leu Ser
    3410                3415                3420                
Asp Pro Ser Ile Val Gly Ser Asn Leu Arg Gln Leu Ala Arg Gly Gln
3425                3430                3435                3440
Ala Gly His Gly Leu Gly Pro Glu Glu Asp Gly Phe Ser Leu Ala Ser
                3445                3450                3455    
Pro Tyr Ser Pro Ala Lys Ser Phe Ser Ala Ser Asp Glu Asp Leu Ile
            3460                3465                3470        
Gln Gln Val Leu Ala Glu Gly Val Ser Ser Pro Ala Pro Thr Gln Asp
        3475                3480                3485            
Thr His Met Glu Thr Asp Leu Leu Ser Ser Leu Ser Ser Thr Pro Gly
    3490                3495                3500                
Glu Lys Thr Glu Thr Leu Ala Leu Gln Arg Leu Gly Glu Leu Gly Pro
3505                3510                3515                3520
Pro Ser Pro Gly Leu Asn Trp Glu Gln Pro Gln Ala Ala Arg Leu Ser
                3525                3530                3535    
Arg Thr Gly Leu Val Glu Gly Leu Arg Lys Arg Leu Leu Pro Ala Trp
            3540                3545                3550        
Cys Ala Ser Leu Ala His Gly Leu Ser Leu Leu Leu Val Ala Val Ala
        3555                3560                3565            
Val Ala Val Ser Gly Trp Val Gly Ala Ser Phe Pro Pro Gly Val Ser
    3570                3575                3580                
Val Ala Trp Leu Leu Ser Ser Ser Ala Ser Phe Leu Ala Ser Phe Leu
3585                3590                3595                3600
Gly Trp Glu Pro Leu Lys Val Leu Leu Glu Ala Leu Tyr Phe Ser Leu
                3605                3610                3615    
Val Ala Lys Arg Leu His Pro Asp Glu Asp Asp Thr Leu Val Glu Ser
            3620                3625                3630        
Pro Ala Val Thr Pro Val Ser Ala Arg Val Pro Arg Val Arg Pro Pro
        3635                3640                3645            
His Gly Phe Ala Leu Phe Leu Ala Lys Glu Glu Ala Arg Lys Val Lys
    3650                3655                3660                
Arg Leu His Gly Met Leu Arg Ser Leu Leu Val Tyr Met Leu Phe Leu
3665                3670                3675                3680
Leu Val Thr Leu Leu Ala Ser Tyr Gly Asp Ala Ser Cys His Gly His
                3685                3690                3695    
Ala Tyr Arg Leu Gln Ser Ala Ile Lys Gln Glu Leu His Ser Arg Ala
            3700                3705                3710        
Phe Leu Ala Ile Thr Arg Ser Glu Glu Leu Trp Pro Trp Met Ala His
        3715                3720                3725            
Val Leu Leu Pro Tyr Val His Gly Asn Gln Ser Ser Pro Glu Leu Gly
    3730                3735                3740                
Pro Pro Arg Leu Arg Gln Val Arg Leu Gln Glu Ala Leu Tyr Pro Asp
3745                3750                3755                3760
Pro Pro Gly Pro Arg Val His Thr Cys Ser Ala Ala Gly Gly Phe Ser
                3765                3770                3775    
Thr Ser Asp Tyr Asp Val Gly Trp Glu Ser Pro His Asn Gly Ser Gly
            3780                3785                3790        
Thr Trp Ala Tyr Ser Ala Pro Asp Leu Leu Gly Ala Trp Ser Trp Gly
        3795                3800                3805            
Ser Cys Ala Val Tyr Asp Ser Gly Gly Tyr Val Gln Glu Leu Gly Leu
    3810                3815                3820                
Ser Leu Glu Glu Ser Arg Asp Arg Leu Arg Phe Leu Gln Leu His Asn
3825                3830                3835                3840
Trp Leu Asp Asn Arg Ser Arg Ala Val Phe Leu Glu Leu Thr Arg Tyr
                3845                3850                3855    
Ser Pro Ala Val Gly Leu His Ala Ala Val Thr Leu Arg Leu Glu Phe
            3860                3865                3870        
Pro Ala Ala Gly Arg Ala Leu Ala Ala Leu Ser Val Arg Pro Phe Ala
        3875                3880                3885            
Leu Arg Arg Leu Ser Ala Gly Leu Ser Leu Pro Leu Leu Thr Ser Val
    3890                3895                3900                
Cys Leu Leu Leu Phe Ala Val His Phe Ala Val Ala Glu Ala Arg Thr
3905                3910                3915                3920
Trp His Arg Glu Gly Arg Trp Arg Val Leu Arg Leu Gly Ala Trp Ala
                3925                3930                3935    
Arg Trp Leu Leu Val Ala Leu Thr Ala Ala Thr Ala Leu Val Arg Leu
            3940                3945                3950        
Ala Gln Leu Gly Ala Ala Asp Arg Gln Trp Thr Arg Phe Val Arg Gly
        3955                3960                3965            
Arg Pro Arg Arg Phe Thr Ser Phe Asp Gln Val Ala Gln Leu Ser Ser
    3970                3975                3980                
Ala Ala Arg Gly Leu Ala Ala Ser Leu Leu Phe Leu Leu Leu Val Lys
3985                3990                3995                4000
Ala Ala Gln Gln Leu Arg Phe Val Arg Gln Trp Ser Val Phe Gly Lys
                4005                4010                4015    
Thr Leu Cys Arg Ala Leu Pro Glu Leu Leu Gly Val Thr Leu Gly Leu
            4020                4025                4030        
Val Val Leu Gly Val Ala Tyr Ala Gln Leu Ala Ile Leu Leu Val Ser
        4035                4040                4045            
Ser Cys Val Asp Ser Leu Trp Ser Val Ala Gln Ala Leu Leu Val Leu
    4050                4055                4060                
Cys Pro Gly Thr Gly Leu Ser Thr Leu Cys Pro Ala Glu Ser Trp His
4065                4070                4075                4080
Leu Ser Pro Leu Leu Cys Val Gly Leu Trp Ala Leu Arg Leu Trp Gly
                4085                4090                4095    
Ala Leu Arg Leu Gly Ala Val Ile Leu Arg Trp Arg Tyr His Ala Leu
            4100                4105                4110        
Arg Gly Glu Leu Tyr Arg Pro Ala Trp Glu Pro Gln Asp Tyr Glu Met
        4115                4120                4125            
Val Glu Leu Phe Leu Arg Arg Leu Arg Leu Trp Met Gly Leu Ser Lys
    4130                4135                4140                
Val Lys Glu Phe Arg His Lys Val Arg Phe Glu Gly Met Glu Pro Leu
4145                4150                4155                4160
Pro Ser Arg Ser Ser Arg Gly Ser Lys Val Ser Pro Asp Val Pro Pro
                4165                4170                4175    
Pro Ser Ala Gly Ser Asp Ala Ser His Pro Ser Thr Ser Ser Ser Gln
            4180                4185                4190        
Leu Asp Gly Leu Ser Val Ser Leu Gly Arg Leu Gly Thr Arg Cys Glu
        4195                4200                4205            
Pro Glu Pro Ser Arg Leu Gln Ala Val Phe Glu Ala Leu Leu Thr Gln
    4210                4215                4220                
Phe Asp Arg Leu Asn Gln Ala Thr Glu Asp Val Tyr Gln Leu Glu Gln
4225                4230                4235                4240
Gln Leu His Ser Leu Gln Gly Arg Arg Ser Ser Arg Ala Pro Ala Gly
                4245                4250                4255    
Ser Ser Arg Gly Pro Ser Pro Gly Leu Arg Pro Ala Leu Pro Ser Arg
            4260                4265                4270        
Leu Ala Arg Ala Ser Arg Gly Val Asp Leu Ala Thr Gly Pro Ser Arg
        4275                4280                4285            
Thr Pro Leu Arg Ala Lys Asn Lys Val His Pro Ser Ser Thr
    4290                4295                4300        


<210> 9204
<211> 4303
<212> PRT
<213> Homo sapiens

<400> 9204
Met Pro Pro Ala Ala Pro Ala Arg Leu Ala Leu Ala Leu Gly Leu Gly
 1               5                  10                  15      
Leu Trp Leu Gly Ala Leu Ala Gly Gly Pro Gly Arg Gly Cys Gly Pro
            20                  25                  30          
Cys Glu Pro Pro Cys Leu Cys Gly Pro Ala Pro Gly Ala Ala Cys Arg
        35                  40                  45              
Val Asn Cys Ser Gly Arg Gly Leu Arg Thr Leu Gly Pro Ala Leu Arg
    50                  55                  60                  
Ile Pro Ala Asp Ala Thr Glu Leu Asp Val Ser His Asn Leu Leu Arg
65                  70                  75                  80  
Ala Leu Asp Val Gly Leu Leu Ala Asn Leu Ser Ala Leu Ala Glu Leu
                85                  90                  95      
Asp Ile Ser Asn Asn Lys Ile Ser Thr Leu Glu Glu Gly Ile Phe Ala
            100                 105                 110         
Asn Leu Phe Asn Leu Ser Glu Ile Asn Leu Ser Gly Asn Pro Phe Glu
        115                 120                 125             
Cys Asp Cys Gly Leu Ala Trp Leu Pro Gln Trp Ala Glu Glu Gln Gln
    130                 135                 140                 
Val Arg Val Val Gln Pro Glu Ala Ala Thr Cys Ala Gly Pro Gly Ser
145                 150                 155                 160 
Leu Ala Gly Gln Pro Leu Leu Gly Ile Pro Leu Leu Asp Ser Gly Cys
                165                 170                 175     
Gly Glu Glu Tyr Val Ala Cys Leu Pro Asp Asn Ser Ser Gly Thr Val
            180                 185                 190         
Ala Ala Val Ser Phe Ser Ala Ala His Glu Gly Leu Leu Gln Pro Glu
        195                 200                 205             
Ala Cys Ser Ala Phe Cys Phe Ser Thr Gly Gln Gly Leu Ala Ala Leu
    210                 215                 220                 
Ser Glu Gln Gly Trp Cys Leu Cys Gly Ala Ala Gln Pro Ser Ser Ala
225                 230                 235                 240 
Ser Phe Ala Cys Leu Ser Leu Cys Ser Gly Pro Pro Ala Pro Pro Ala
                245                 250                 255     
Pro Thr Cys Arg Gly Pro Thr Leu Leu Gln His Val Phe Pro Ala Ser
            260                 265                 270         
Pro Gly Ala Thr Leu Val Gly Pro His Gly Pro Leu Ala Ser Gly Gln
        275                 280                 285             
Leu Ala Ala Phe His Ile Ala Ala Pro Leu Pro Val Thr Asp Thr Arg
    290                 295                 300                 
Trp Asp Phe Gly Asp Gly Ser Ala Glu Val Asp Ala Ala Gly Pro Ala
305                 310                 315                 320 
Ala Ser His Arg Tyr Val Leu Pro Gly Arg Tyr His Val Thr Ala Val
                325                 330                 335     
Leu Ala Leu Gly Ala Gly Ser Ala Leu Leu Gly Thr Asp Val Gln Val
            340                 345                 350         
Glu Ala Ala Pro Ala Ala Leu Glu Leu Val Cys Pro Ser Ser Val Gln
        355                 360                 365             
Ser Asp Glu Ser Leu Asp Leu Ser Ile Gln Asn Arg Gly Gly Ser Gly
    370                 375                 380                 
Leu Glu Ala Ala Tyr Ser Ile Val Ala Leu Gly Glu Glu Pro Ala Arg
385                 390                 395                 400 
Ala Val His Pro Leu Cys Pro Ser Asp Thr Glu Ile Phe Pro Gly Asn
                405                 410                 415     
Gly His Cys Tyr Arg Leu Val Val Glu Lys Ala Ala Trp Leu Gln Ala
            420                 425                 430         
Gln Glu Gln Cys Gln Ala Trp Ala Gly Ala Ala Leu Ala Met Val Asp
        435                 440                 445             
Ser Pro Ala Val Gln Arg Phe Leu Val Ser Arg Val Thr Arg Ser Leu
    450                 455                 460                 
Asp Val Trp Ile Gly Phe Ser Thr Val Gln Gly Val Glu Val Gly Pro
465                 470                 475                 480 
Ala Pro Gln Gly Glu Ala Phe Ser Leu Glu Ser Cys Gln Asn Trp Leu
                485                 490                 495     
Pro Gly Glu Pro His Pro Ala Thr Ala Glu His Cys Val Arg Leu Gly
            500                 505                 510         
Pro Thr Gly Trp Cys Asn Thr Asp Leu Cys Ser Ala Pro His Ser Tyr
        515                 520                 525             
Val Cys Glu Leu Gln Pro Gly Gly Pro Val Gln Asp Ala Glu Asn Leu
    530                 535                 540                 
Leu Val Gly Ala Pro Ser Gly Asp Leu Gln Gly Pro Leu Thr Pro Leu
545                 550                 555                 560 
Ala Gln Gln Asp Gly Leu Ser Ala Pro His Glu Pro Val Glu Val Met
                565                 570                 575     
Val Phe Pro Gly Leu Arg Leu Ser Arg Glu Ala Phe Leu Thr Thr Ala
            580                 585                 590         
Glu Phe Gly Thr Gln Glu Leu Arg Arg Pro Ala Gln Leu Arg Leu Gln
        595                 600                 605             
Val Tyr Arg Leu Leu Ser Thr Ala Gly Thr Pro Glu Asn Gly Ser Glu
    610                 615                 620                 
Pro Glu Ser Arg Ser Pro Asp Asn Arg Thr Gln Leu Ala Pro Ala Cys
625                 630                 635                 640 
Met Pro Gly Gly Arg Trp Cys Pro Gly Ala Asn Ile Cys Leu Pro Leu
                645                 650                 655     
Asp Ala Ser Cys His Pro Gln Ala Cys Ala Asn Gly Cys Thr Ser Gly
            660                 665                 670         
Pro Gly Leu Pro Gly Ala Pro Tyr Ala Leu Trp Arg Glu Phe Leu Phe
        675                 680                 685             
Ser Val Pro Ala Gly Pro Pro Ala Gln Tyr Ser Val Thr Leu His Gly
    690                 695                 700                 
Gln Asp Val Leu Met Leu Pro Gly Asp Leu Val Gly Leu Gln His Asp
705                 710                 715                 720 
Ala Gly Pro Gly Ala Leu Leu His Cys Ser Pro Ala Pro Gly His Pro
                725                 730                 735     
Gly Pro Arg Ala Pro Tyr Leu Ser Ala Asn Ala Ser Ser Trp Leu Pro
            740                 745                 750         
His Leu Pro Ala Gln Leu Glu Gly Thr Trp Gly Cys Pro Ala Cys Ala
        755                 760                 765             
Leu Arg Leu Leu Ala Gln Arg Glu Gln Leu Thr Val Leu Leu Gly Leu
    770                 775                 780                 
Arg Pro Asn Pro Gly Leu Arg Leu Pro Gly Arg Tyr Glu Val Arg Ala
785                 790                 795                 800 
Glu Val Gly Asn Gly Val Ser Arg His Asn Leu Ser Cys Ser Phe Asp
                805                 810                 815     
Val Val Ser Pro Val Ala Gly Leu Arg Val Ile Tyr Pro Ala Pro Arg
            820                 825                 830         
Asp Gly Arg Leu Tyr Val Pro Thr Asn Gly Ser Ala Leu Val Leu Gln
        835                 840                 845             
Val Asp Ser Gly Ala Asn Ala Thr Ala Thr Ala Arg Trp Pro Gly Gly
    850                 855                 860                 
Ser Leu Ser Ala Arg Phe Glu Asn Val Cys Pro Ala Leu Val Ala Thr
865                 870                 875                 880 
Phe Val Pro Ala Cys Pro Trp Glu Thr Asn Asp Thr Leu Phe Ser Val
                885                 890                 895     
Val Ala Leu Pro Trp Leu Ser Glu Gly Glu His Val Val Asp Val Val
            900                 905                 910         
Val Glu Asn Ser Ala Ser Arg Ala Asn Leu Ser Leu Arg Val Thr Ala
        915                 920                 925             
Glu Glu Pro Ile Cys Gly Leu Arg Ala Thr Pro Ser Pro Glu Ala Arg
    930                 935                 940                 
Val Leu Gln Gly Val Leu Val Arg Tyr Ser Pro Val Val Glu Ala Gly
945                 950                 955                 960 
Ser Asp Met Val Phe Arg Trp Thr Ile Asn Asp Lys Gln Ser Leu Thr
                965                 970                 975     
Phe Gln Asn Val Val Phe Asn Val Ile Tyr Gln Ser Ala Ala Val Phe
            980                 985                 990         
Lys Leu Ser Leu Thr Ala Ser Asn His Val Ser Asn Val Thr Val Asn
        995                 1000                1005            
Tyr Asn Val Thr Val Glu Arg Met Asn Arg Met Gln Gly Leu Gln Val
    1010                1015                1020                
Ser Thr Val Pro Ala Val Leu Ser Pro Asn Ala Thr Leu Ala Leu Thr
1025                1030                1035                1040
Ala Gly Val Leu Val Asp Ser Ala Val Glu Val Ala Phe Leu Trp Thr
                1045                1050                1055    
Phe Gly Asp Gly Glu Gln Ala Leu His Gln Phe Gln Pro Pro Tyr Asn
            1060                1065                1070        
Glu Ser Phe Pro Val Pro Asp Pro Ser Val Ala Gln Val Leu Val Glu
        1075                1080                1085            
His Asn Val Thr His Thr Tyr Ala Ala Pro Gly Glu Tyr Leu Leu Thr
    1090                1095                1100                
Val Leu Ala Ser Asn Ala Phe Glu Asn Leu Thr Gln Gln Val Pro Val
1105                1110                1115                1120
Ser Val Arg Ala Ser Leu Pro Ser Val Ala Val Gly Val Ser Asp Gly
                1125                1130                1135    
Val Leu Val Ala Gly Arg Pro Val Thr Phe Tyr Pro His Pro Leu Pro
            1140                1145                1150        
Ser Pro Gly Gly Val Leu Tyr Thr Trp Asp Phe Gly Asp Gly Ser Pro
        1155                1160                1165            
Val Leu Thr Gln Ser Gln Pro Ala Ala Asn His Thr Tyr Ala Ser Arg
    1170                1175                1180                
Gly Thr Tyr His Val Arg Leu Glu Val Asn Asn Thr Val Ser Gly Ala
1185                1190                1195                1200
Ala Ala Gln Ala Asp Val Arg Val Phe Glu Glu Leu Arg Gly Leu Ser
                1205                1210                1215    
Val Asp Met Ser Leu Ala Val Glu Gln Gly Ala Pro Val Val Val Ser
            1220                1225                1230        
Ala Ala Val Gln Thr Gly Asp Asn Ile Thr Trp Thr Phe Asp Met Gly
        1235                1240                1245            
Asp Gly Thr Val Leu Ser Gly Pro Glu Ala Thr Val Glu His Val Tyr
    1250                1255                1260                
Leu Arg Ala Gln Asn Cys Thr Val Thr Val Gly Ala Gly Ser Pro Ala
1265                1270                1275                1280
Gly His Leu Ala Arg Ser Leu His Val Leu Val Phe Val Leu Glu Val
                1285                1290                1295    
Leu Arg Val Glu Pro Ala Ala Cys Ile Pro Thr Gln Pro Asp Ala Arg
            1300                1305                1310        
Leu Thr Ala Tyr Val Thr Gly Asn Pro Ala His Tyr Leu Phe Asp Trp
        1315                1320                1325            
Thr Phe Gly Asp Gly Ser Ser Asn Thr Thr Val Arg Gly Cys Pro Thr
    1330                1335                1340                
Val Thr His Asn Phe Thr Arg Ser Gly Thr Phe Pro Leu Ala Leu Val
1345                1350                1355                1360
Leu Ser Ser Arg Val Asn Arg Ala His Tyr Phe Thr Ser Ile Cys Val
                1365                1370                1375    
Glu Pro Glu Val Gly Asn Val Thr Leu Gln Pro Glu Arg Gln Phe Val
            1380                1385                1390        
Gln Leu Gly Asp Glu Ala Trp Leu Val Ala Cys Ala Trp Pro Pro Phe
        1395                1400                1405            
Pro Tyr Arg Tyr Thr Trp Asp Phe Gly Thr Glu Glu Ala Ala Pro Thr
    1410                1415                1420                
Arg Ala Arg Gly Pro Glu Val Thr Phe Ile Tyr Arg Asp Pro Gly Ser
1425                1430                1435                1440
Tyr Leu Val Thr Val Thr Ala Ser Asn Asn Ile Ser Ala Ala Asn Asp
                1445                1450                1455    
Ser Ala Leu Val Glu Val Gln Glu Pro Val Leu Val Thr Ser Ile Lys
            1460                1465                1470        
Val Asn Gly Ser Leu Gly Leu Glu Leu Gln Gln Pro Tyr Leu Phe Ser
        1475                1480                1485            
Ala Val Gly Arg Gly Arg Pro Ala Ser Tyr Leu Trp Asp Leu Gly Asp
    1490                1495                1500                
Gly Gly Trp Leu Glu Gly Pro Glu Val Thr His Ala Tyr Asn Ser Thr
1505                1510                1515                1520
Gly Asp Phe Thr Val Arg Val Ala Gly Trp Asn Glu Val Ser Arg Ser
                1525                1530                1535    
Glu Ala Trp Leu Asn Val Thr Val Lys Arg Arg Val Arg Gly Leu Val
            1540                1545                1550        
Val Asn Ala Ser Arg Thr Val Val Pro Leu Asn Gly Ser Val Ser Phe
        1555                1560                1565            
Ser Thr Ser Leu Glu Ala Gly Ser Asp Val Arg Tyr Ser Trp Val Leu
    1570                1575                1580                
Cys Asp Arg Cys Thr Pro Ile Pro Gly Gly Pro Thr Ile Ser Tyr Thr
1585                1590                1595                1600
Phe Arg Ser Val Gly Thr Phe Asn Ile Ile Val Thr Ala Glu Asn Glu
                1605                1610                1615    
Val Gly Ser Ala Gln Asp Ser Ile Phe Val Tyr Val Leu Gln Leu Ile
            1620                1625                1630        
Glu Gly Leu Gln Val Val Gly Gly Gly Arg Tyr Phe Pro Thr Asn His
        1635                1640                1645            
Thr Val Gln Leu Gln Ala Val Val Arg Asp Gly Thr Asn Val Ser Tyr
    1650                1655                1660                
Ser Trp Thr Ala Trp Arg Asp Arg Gly Pro Ala Leu Ala Gly Ser Gly
1665                1670                1675                1680
Lys Gly Phe Ser Leu Thr Val Leu Glu Ala Gly Thr Tyr His Val Gln
                1685                1690                1695    
Leu Arg Ala Thr Asn Met Leu Gly Ser Ala Trp Ala Asp Cys Thr Met
            1700                1705                1710        
Asp Phe Val Glu Pro Val Gly Trp Leu Met Val Ala Ala Ser Pro Asn
        1715                1720                1725            
Pro Ala Ala Val Asn Thr Ser Val Thr Leu Ser Ala Glu Leu Ala Gly
    1730                1735                1740                
Gly Ser Gly Val Val Tyr Thr Trp Ser Leu Glu Glu Gly Leu Ser Trp
1745                1750                1755                1760
Glu Thr Ser Glu Pro Phe Thr Thr His Ser Phe Pro Thr Pro Gly Leu
                1765                1770                1775    
His Leu Val Thr Met Thr Ala Gly Asn Pro Leu Gly Ser Ala Asn Ala
            1780                1785                1790        
Thr Val Glu Val Asp Val Gln Val Pro Val Ser Gly Leu Ser Ile Arg
        1795                1800                1805            
Ala Ser Glu Pro Gly Gly Ser Phe Val Ala Ala Gly Ser Ser Val Pro
    1810                1815                1820                
Phe Trp Gly Gln Leu Ala Thr Gly Thr Asn Val Ser Trp Cys Trp Ala
1825                1830                1835                1840
Val Pro Gly Gly Ser Ser Lys Arg Gly Pro His Val Thr Met Val Phe
                1845                1850                1855    
Pro Asp Ala Gly Thr Phe Ser Ile Arg Leu Asn Ala Ser Asn Ala Val
            1860                1865                1870        
Ser Trp Val Ser Ala Thr Tyr Asn Leu Thr Ala Glu Glu Pro Ile Val
        1875                1880                1885            
Gly Leu Val Leu Trp Ala Ser Ser Lys Val Val Ala Pro Gly Gln Leu
    1890                1895                1900                
Val His Phe Gln Ile Leu Leu Ala Ala Gly Ser Ala Val Thr Phe Arg
1905                1910                1915                1920
Leu Gln Val Gly Gly Ala Asn Pro Glu Val Leu Pro Gly Pro Arg Phe
                1925                1930                1935    
Ser His Ser Phe Pro Arg Val Gly Asp His Val Val Ser Val Arg Gly
            1940                1945                1950        
Lys Asn His Val Ser Trp Ala Gln Ala Gln Val Arg Ile Val Val Leu
        1955                1960                1965            
Glu Ala Val Ser Gly Leu Gln Val Pro Asn Cys Cys Glu Pro Gly Ile
    1970                1975                1980                
Ala Thr Gly Thr Glu Arg Asn Phe Thr Ala Arg Val Gln Arg Gly Ser
1985                1990                1995                2000
Arg Val Ala Tyr Ala Trp Tyr Phe Ser Leu Gln Lys Val Gln Gly Asp
                2005                2010                2015    
Ser Leu Val Ile Leu Ser Gly Arg Asp Val Thr Tyr Thr Pro Val Ala
            2020                2025                2030        
Ala Gly Leu Leu Glu Ile Gln Val Arg Ala Phe Asn Ala Leu Gly Ser
        2035                2040                2045            
Glu Asn Arg Thr Leu Val Leu Glu Val Gln Asp Ala Val Gln Tyr Val
    2050                2055                2060                
Ala Leu Gln Ser Gly Pro Cys Phe Thr Asn Arg Ser Ala Gln Phe Glu
2065                2070                2075                2080
Ala Ala Thr Ser Pro Ser Pro Arg Arg Val Ala Tyr His Trp Asp Phe
                2085                2090                2095    
Gly Asp Gly Ser Pro Gly Gln Asp Thr Asp Glu Pro Arg Ala Glu His
            2100                2105                2110        
Ser Tyr Leu Arg Pro Gly Asp Tyr Arg Val Gln Val Asn Ala Ser Asn
        2115                2120                2125            
Leu Val Ser Phe Phe Val Ala Gln Ala Thr Val Thr Val Gln Val Leu
    2130                2135                2140                
Ala Cys Arg Glu Pro Glu Val Asp Val Val Leu Pro Leu Gln Val Leu
2145                2150                2155                2160
Met Arg Arg Ser Gln Arg Asn Tyr Leu Glu Ala His Val Asp Leu Arg
                2165                2170                2175    
Asp Cys Val Thr Tyr Gln Thr Glu Tyr Arg Trp Glu Val Tyr Arg Thr
            2180                2185                2190        
Ala Ser Cys Gln Arg Pro Gly Arg Pro Ala Arg Val Ala Leu Pro Gly
        2195                2200                2205            
Val Asp Val Ser Arg Pro Arg Leu Val Leu Pro Arg Leu Ala Leu Pro
    2210                2215                2220                
Val Gly His Tyr Cys Phe Val Phe Val Val Ser Phe Gly Asp Thr Pro
2225                2230                2235                2240
Leu Thr Gln Ser Ile Gln Ala Asn Val Thr Val Ala Pro Glu Arg Leu
                2245                2250                2255    
Val Pro Ile Ile Glu Gly Gly Ser Tyr Arg Val Trp Ser Asp Thr Arg
            2260                2265                2270        
Asp Leu Val Leu Asp Gly Ser Glu Ser Tyr Asp Pro Asn Leu Glu Asp
        2275                2280                2285            
Gly Asp Gln Thr Pro Leu Ser Phe His Trp Ala Cys Val Ala Ser Thr
    2290                2295                2300                
Gln Arg Glu Ala Gly Gly Cys Ala Leu Asn Phe Gly Pro Arg Gly Ser
2305                2310                2315                2320
Ser Thr Val Thr Ile Pro Arg Glu Arg Leu Ala Ala Gly Val Glu Tyr
                2325                2330                2335    
Thr Phe Ser Leu Thr Val Trp Lys Ala Gly Arg Lys Glu Glu Ala Thr
            2340                2345                2350        
Asn Gln Thr Val Leu Ile Arg Ser Gly Arg Val Pro Ile Val Ser Leu
        2355                2360                2365            
Glu Cys Val Ser Cys Lys Ala Gln Ala Val Tyr Glu Val Ser Arg Ser
    2370                2375                2380                
Ser Tyr Val Tyr Leu Glu Gly Arg Cys Leu Asn Cys Ser Ser Gly Ser
2385                2390                2395                2400
Lys Arg Gly Arg Trp Ala Ala Arg Thr Phe Ser Asn Lys Thr Leu Val
                2405                2410                2415    
Leu Asp Glu Thr Thr Thr Ser Thr Gly Ser Ala Gly Met Arg Leu Val
            2420                2425                2430        
Leu Arg Arg Gly Val Leu Arg Asp Gly Glu Gly Tyr Thr Phe Thr Leu
        2435                2440                2445            
Thr Val Leu Gly Arg Ser Gly Glu Glu Glu Gly Cys Ala Ser Ile Arg
    2450                2455                2460                
Leu Ser Pro Asn Arg Pro Pro Leu Gly Gly Ser Cys Arg Leu Phe Pro
2465                2470                2475                2480
Leu Gly Ala Val His Ala Leu Thr Thr Lys Val His Phe Glu Cys Thr
                2485                2490                2495    
Gly Trp His Asp Ala Glu Asp Ala Gly Ala Pro Leu Val Tyr Ala Leu
            2500                2505                2510        
Leu Leu Arg Arg Cys Arg Gln Gly His Cys Glu Glu Phe Cys Val Tyr
        2515                2520                2525            
Lys Gly Ser Leu Ser Ser Tyr Gly Ala Val Leu Pro Pro Gly Phe Arg
    2530                2535                2540                
Pro His Phe Glu Val Gly Leu Ala Val Val Val Gln Asp Gln Leu Gly
2545                2550                2555                2560
Ala Ala Val Val Ala Leu Asn Arg Ser Leu Ala Ile Thr Leu Pro Glu
                2565                2570                2575    
Pro Asn Gly Ser Ala Thr Gly Leu Thr Val Trp Leu His Gly Leu Thr
            2580                2585                2590        
Ala Ser Val Leu Pro Gly Leu Leu Arg Gln Ala Asp Pro Gln His Val
        2595                2600                2605            
Ile Glu Tyr Ser Leu Ala Leu Val Thr Val Leu Asn Glu Tyr Glu Arg
    2610                2615                2620                
Ala Leu Asp Val Ala Ala Glu Pro Lys His Glu Arg Gln His Arg Ala
2625                2630                2635                2640
Gln Ile Arg Lys Asn Ile Thr Glu Thr Leu Val Ser Leu Arg Val His
                2645                2650                2655    
Thr Val Asp Asp Ile Gln Gln Ile Ala Ala Ala Leu Ala Gln Cys Met
            2660                2665                2670        
Gly Pro Ser Arg Glu Leu Val Cys Arg Ser Cys Leu Lys Gln Thr Leu
        2675                2680                2685            
His Lys Leu Glu Ala Met Met Leu Ile Leu Gln Ala Glu Thr Thr Ala
    2690                2695                2700                
Gly Thr Val Thr Pro Thr Ala Ile Gly Asp Ser Ile Leu Asn Ile Thr
2705                2710                2715                2720
Gly Asp Leu Ile His Leu Ala Ser Ser Asp Val Arg Ala Pro Gln Pro
                2725                2730                2735    
Ser Glu Leu Gly Ala Glu Ser Pro Ser Arg Met Val Ala Ser Gln Ala
            2740                2745                2750        
Tyr Asn Leu Thr Ser Ala Leu Met Arg Ile Leu Met Arg Ser Arg Val
        2755                2760                2765            
Leu Asn Glu Glu Pro Leu Thr Leu Ala Gly Glu Glu Ile Val Ala Gln
    2770                2775                2780                
Gly Lys Arg Ser Asp Pro Arg Ser Leu Leu Cys Tyr Gly Gly Ala Pro
2785                2790                2795                2800
Gly Pro Gly Cys His Phe Ser Ile Pro Glu Ala Phe Ser Gly Ala Leu
                2805                2810                2815    
Ala Asn Leu Ser Asp Val Val Gln Leu Ile Phe Leu Val Asp Ser Asn
            2820                2825                2830        
Pro Phe Pro Phe Gly Tyr Ile Ser Asn Tyr Thr Val Ser Thr Lys Val
        2835                2840                2845            
Ala Ser Met Ala Phe Gln Thr Gln Ala Gly Ala Gln Ile Pro Ile Glu
    2850                2855                2860                
Arg Leu Ala Ser Glu Arg Ala Ile Thr Val Lys Val Pro Asn Asn Ser
2865                2870                2875                2880
Asp Trp Ala Ala Arg Gly His Arg Ser Ser Ala Asn Ser Ala Asn Ser
                2885                2890                2895    
Val Val Val Gln Pro Gln Ala Ser Val Gly Ala Val Val Thr Leu Asp
            2900                2905                2910        
Ser Ser Asn Pro Ala Ala Gly Leu His Leu Gln Leu Asn Tyr Thr Leu
        2915                2920                2925            
Leu Asp Gly His Tyr Leu Ser Glu Glu Pro Glu Pro Tyr Leu Ala Val
    2930                2935                2940                
Tyr Leu His Ser Glu Pro Arg Pro Asn Glu His Asn Cys Ser Ala Ser
2945                2950                2955                2960
Arg Arg Ile Arg Pro Glu Ser Leu Gln Gly Ala Asp His Arg Pro Tyr
                2965                2970                2975    
Thr Phe Phe Ile Ser Pro Gly Ser Arg Asp Pro Ala Gly Ser Tyr His
            2980                2985                2990        
Leu Asn Leu Ser Ser His Phe Arg Trp Ser Ala Leu Gln Val Ser Val
        2995                3000                3005            
Gly Leu Tyr Thr Ser Leu Cys Gln Tyr Phe Ser Glu Glu Asp Met Val
    3010                3015                3020                
Trp Arg Thr Glu Gly Leu Leu Pro Leu Glu Glu Thr Ser Pro Arg Gln
3025                3030                3035                3040
Ala Val Cys Leu Thr Arg His Leu Thr Ala Phe Gly Ala Ser Leu Phe
                3045                3050                3055    
Val Pro Pro Ser His Val Arg Phe Val Phe Pro Glu Pro Thr Ala Asp
            3060                3065                3070        
Val Asn Tyr Ile Val Met Leu Thr Cys Ala Val Cys Leu Val Thr Tyr
        3075                3080                3085            
Met Val Met Ala Ala Ile Leu His Lys Leu Asp Gln Leu Asp Ala Ser
    3090                3095                3100                
Arg Gly Arg Ala Ile Pro Phe Cys Gly Gln Arg Gly Arg Phe Lys Tyr
3105                3110                3115                3120
Glu Ile Leu Val Lys Thr Gly Trp Gly Arg Gly Ser Gly Thr Thr Ala
                3125                3130                3135    
His Val Gly Ile Met Leu Tyr Gly Val Asp Ser Arg Ser Gly His Arg
            3140                3145                3150        
His Leu Asp Gly Asp Arg Ala Phe His Arg Asn Ser Leu Asp Ile Phe
        3155                3160                3165            
Arg Ile Ala Thr Pro His Ser Leu Gly Ser Val Trp Lys Ile Arg Val
    3170                3175                3180                
Trp His Asp Asn Lys Gly Leu Ser Pro Ala Trp Phe Leu Gln His Val
3185                3190                3195                3200
Ile Val Arg Asp Leu Gln Thr Ala Arg Ser Ala Phe Phe Leu Val Asn
                3205                3210                3215    
Asp Trp Leu Ser Val Glu Thr Glu Ala Asn Gly Gly Leu Val Glu Lys
            3220                3225                3230        
Glu Val Leu Ala Ala Ser Asp Ala Ala Leu Leu Arg Phe Arg Arg Leu
        3235                3240                3245            
Leu Val Ala Glu Leu Gln Arg Gly Phe Phe Asp Lys His Ile Trp Leu
    3250                3255                3260                
Ser Ile Trp Asp Arg Pro Pro Arg Ser Arg Phe Thr Arg Ile Gln Arg
3265                3270                3275                3280
Ala Thr Cys Cys Val Leu Leu Ile Cys Leu Phe Leu Gly Ala Asn Ala
                3285                3290                3295    
Val Trp Tyr Gly Ala Val Gly Asp Ser Ala Tyr Ser Thr Gly His Val
            3300                3305                3310        
Ser Arg Leu Ser Pro Leu Ser Val Asp Thr Val Ala Val Gly Leu Val
        3315                3320                3325            
Ser Ser Val Val Val Tyr Pro Val Tyr Leu Ala Ile Leu Phe Leu Phe
    3330                3335                3340                
Arg Met Ser Arg Ser Lys Val Ala Gly Ser Pro Ser Pro Thr Pro Ala
3345                3350                3355                3360
Gly Gln Gln Val Leu Asp Ile Asp Ser Cys Leu Asp Ser Ser Val Leu
                3365                3370                3375    
Asp Ser Ser Phe Leu Thr Phe Ser Gly Leu His Ala Glu Gln Ala Phe
            3380                3385                3390        
Val Gly Gln Met Lys Ser Asp Leu Phe Leu Asp Asp Ser Lys Ser Leu
        3395                3400                3405            
Val Cys Trp Pro Ser Gly Glu Gly Thr Leu Ser Trp Pro Asp Leu Leu
    3410                3415                3420                
Ser Asp Pro Ser Ile Val Gly Ser Asn Leu Arg Gln Leu Ala Arg Gly
3425                3430                3435                3440
Gln Ala Gly His Gly Leu Gly Pro Glu Glu Asp Gly Phe Ser Leu Ala
                3445                3450                3455    
Ser Pro Tyr Ser Pro Ala Lys Ser Phe Ser Ala Ser Asp Glu Asp Leu
            3460                3465                3470        
Ile Gln Gln Val Leu Ala Glu Gly Val Ser Ser Pro Ala Pro Thr Gln
        3475                3480                3485            
Asp Thr His Met Glu Thr Asp Leu Leu Ser Ser Leu Ser Ser Thr Pro
    3490                3495                3500                
Gly Glu Lys Thr Glu Thr Leu Ala Leu Gln Arg Leu Gly Glu Leu Gly
3505                3510                3515                3520
Pro Pro Ser Pro Gly Leu Asn Trp Glu Gln Pro Gln Ala Ala Arg Leu
                3525                3530                3535    
Ser Arg Thr Gly Leu Val Glu Gly Leu Arg Lys Arg Leu Leu Pro Ala
            3540                3545                3550        
Trp Cys Ala Ser Leu Ala His Gly Leu Ser Leu Leu Leu Val Ala Val
        3555                3560                3565            
Ala Val Ala Val Ser Gly Trp Val Gly Ala Ser Phe Pro Pro Gly Val
    3570                3575                3580                
Ser Val Ala Trp Leu Leu Ser Ser Ser Ala Ser Phe Leu Ala Ser Phe
3585                3590                3595                3600
Leu Gly Trp Glu Pro Leu Lys Val Leu Leu Glu Ala Leu Tyr Phe Ser
                3605                3610                3615    
Leu Val Ala Lys Arg Leu His Pro Asp Glu Asp Asp Thr Leu Val Glu
            3620                3625                3630        
Ser Pro Ala Val Thr Pro Val Ser Ala Arg Val Pro Arg Val Arg Pro
        3635                3640                3645            
Pro His Gly Phe Ala Leu Phe Leu Ala Lys Glu Glu Ala Arg Lys Val
    3650                3655                3660                
Lys Arg Leu His Gly Met Leu Arg Ser Leu Leu Val Tyr Met Leu Phe
3665                3670                3675                3680
Leu Leu Val Thr Leu Leu Ala Ser Tyr Gly Asp Ala Ser Cys His Gly
                3685                3690                3695    
His Ala Tyr Arg Leu Gln Ser Ala Ile Lys Gln Glu Leu His Ser Arg
            3700                3705                3710        
Ala Phe Leu Ala Ile Thr Arg Ser Glu Glu Leu Trp Pro Trp Met Ala
        3715                3720                3725            
His Val Leu Leu Pro Tyr Val His Gly Asn Gln Ser Ser Pro Glu Leu
    3730                3735                3740                
Gly Pro Pro Arg Leu Arg Gln Val Arg Leu Gln Glu Ala Leu Tyr Pro
3745                3750                3755                3760
Asp Pro Pro Gly Pro Arg Val His Thr Cys Ser Ala Ala Gly Gly Phe
                3765                3770                3775    
Ser Thr Ser Asp Tyr Asp Val Gly Trp Glu Ser Pro His Asn Gly Ser
            3780                3785                3790        
Gly Thr Trp Ala Tyr Ser Ala Pro Asp Leu Leu Gly Ala Trp Ser Trp
        3795                3800                3805            
Gly Ser Cys Ala Val Tyr Asp Ser Gly Gly Tyr Val Gln Glu Leu Gly
    3810                3815                3820                
Leu Ser Leu Glu Glu Ser Arg Asp Arg Leu Arg Phe Leu Gln Leu His
3825                3830                3835                3840
Asn Trp Leu Asp Asn Arg Ser Arg Ala Val Phe Leu Glu Leu Thr Arg
                3845                3850                3855    
Tyr Ser Pro Ala Val Gly Leu His Ala Ala Val Thr Leu Arg Leu Glu
            3860                3865                3870        
Phe Pro Ala Ala Gly Arg Ala Leu Ala Ala Leu Ser Val Arg Pro Phe
        3875                3880                3885            
Ala Leu Arg Arg Leu Ser Ala Gly Leu Ser Leu Pro Leu Leu Thr Ser
    3890                3895                3900                
Val Cys Leu Leu Leu Phe Ala Val His Phe Ala Val Ala Glu Ala Arg
3905                3910                3915                3920
Thr Trp His Arg Glu Gly Arg Trp Arg Val Leu Arg Leu Gly Ala Trp
                3925                3930                3935    
Ala Arg Trp Leu Leu Val Ala Leu Thr Ala Ala Thr Ala Leu Val Arg
            3940                3945                3950        
Leu Ala Gln Leu Gly Ala Ala Asp Arg Gln Trp Thr Arg Phe Val Arg
        3955                3960                3965            
Gly Arg Pro Arg Arg Phe Thr Ser Phe Asp Gln Val Ala His Val Ser
    3970                3975                3980                
Ser Ala Ala Arg Gly Leu Ala Ala Ser Leu Leu Phe Leu Leu Leu Val
3985                3990                3995                4000
Lys Ala Ala Gln His Val Arg Phe Val Arg Gln Trp Ser Val Phe Gly
                4005                4010                4015    
Lys Thr Leu Cys Arg Ala Leu Pro Glu Leu Leu Gly Val Thr Leu Gly
            4020                4025                4030        
Leu Val Val Leu Gly Val Ala Tyr Ala Gln Leu Ala Ile Leu Leu Val
        4035                4040                4045            
Ser Ser Cys Val Asp Ser Leu Trp Ser Val Ala Gln Ala Leu Leu Val
    4050                4055                4060                
Leu Cys Pro Gly Thr Gly Leu Ser Thr Leu Cys Pro Ala Glu Ser Trp
4065                4070                4075                4080
His Leu Ser Pro Leu Leu Cys Val Gly Leu Trp Ala Leu Arg Leu Trp
                4085                4090                4095    
Gly Ala Leu Arg Leu Gly Ala Val Ile Leu Arg Trp Arg Tyr His Ala
            4100                4105                4110        
Leu Arg Gly Glu Leu Tyr Arg Pro Ala Trp Glu Pro Gln Asp Tyr Glu
        4115                4120                4125            
Met Val Glu Leu Phe Leu Arg Arg Leu Arg Leu Trp Met Gly Leu Ser
    4130                4135                4140                
Lys Val Lys Glu Phe Arg His Lys Val Arg Phe Glu Gly Met Glu Pro
4145                4150                4155                4160
Leu Pro Ser Arg Ser Ser Arg Gly Ser Lys Val Ser Pro Asp Val Pro
                4165                4170                4175    
Pro Pro Ser Ala Gly Ser Asp Ala Ser His Pro Ser Thr Ser Ser Ser
            4180                4185                4190        
Gln Leu Asp Gly Leu Ser Val Ser Leu Gly Arg Leu Gly Thr Arg Cys
        4195                4200                4205            
Glu Pro Glu Pro Ser Arg Leu Gln Ala Val Phe Glu Ala Leu Leu Thr
    4210                4215                4220                
Gln Phe Asp Arg Leu Asn Gln Ala Thr Glu Asp Val Tyr Gln Leu Glu
4225                4230                4235                4240
Gln Gln Leu His Ser Leu Gln Gly Arg Arg Ser Ser Arg Ala Pro Ala
                4245                4250                4255    
Gly Ser Ser Arg Gly Pro Ser Pro Gly Leu Arg Pro Ala Leu Pro Ser
            4260                4265                4270        
Arg Leu Ala Arg Ala Ser Arg Gly Val Asp Leu Ala Thr Gly Pro Ser
        4275                4280                4285            
Arg Thr Pro Leu Arg Ala Lys Asn Lys Val His Pro Ser Ser Thr
    4290                4295                4300            


<210> 9205
<211> 3638
<212> PRT
<213> Homo sapiens

<400> 9205
Met Pro Pro Ala Ala Pro Ala Arg Leu Ala Leu Ala Leu Gly Leu Gly
 1               5                  10                  15      
Leu Trp Leu Gly Ala Leu Ala Gly Gly Pro Gly Arg Gly Cys Gly Pro
            20                  25                  30          
Cys Glu Pro Pro Cys Leu Cys Gly Pro Ala Pro Gly Ala Ala Cys Arg
        35                  40                  45              
Val Asn Cys Ser Gly Arg Gly Leu Arg Thr Leu Gly Pro Ala Leu Arg
    50                  55                  60                  
Ile Pro Ala Asp Ala Thr Ala Leu Thr Ala Met Ala Lys Ala Asp Gly
65                  70                  75                  80  
Asp Val Lys Lys Tyr Gly Ser Lys Arg Gly Ala Leu Ala Leu Thr His
                85                  90                  95      
Gly His Ser Leu Leu Arg Asp Val Ser His Asn Leu Leu Arg Ala Leu
            100                 105                 110         
Asp Val Gly Leu Leu Ala Asn Leu Ser Ala Leu Ala Glu Leu Asp Ile
        115                 120                 125             
Ser Asn Asn Lys Ile Ser Thr Leu Glu Glu Gly Ile Phe Ala Asn Leu
    130                 135                 140                 
Phe Asn Leu Ser Glu Ile Asn Leu Ser Gly Asn Pro Phe Glu Cys Asp
145                 150                 155                 160 
Cys Gly Leu Ala Trp Leu Pro Arg Trp Ala Glu Glu Gln Gln Val Arg
                165                 170                 175     
Val Val Gln Pro Glu Ala Ala Thr Cys Ala Gly Pro Gly Ser Leu Ala
            180                 185                 190         
Gly Gln Pro Leu Leu Gly Ile Pro Leu Leu Asp Ser Gly Cys Gly Ala
        195                 200                 205             
Thr Leu Val Gly Pro His Gly Pro Leu Ala Ser Gly Gln Leu Ala Ala
    210                 215                 220                 
Phe His Ile Ala Ala Pro Leu Pro Val Thr Ala Thr Arg Trp Asp Phe
225                 230                 235                 240 
Gly Asp Gly Ser Ala Glu Val Asp Ala Ala Gly Pro Ala Ala Ser His
                245                 250                 255     
Arg Tyr Val Leu Pro Gly Arg Tyr His Val Thr Ala Val Leu Ala Leu
            260                 265                 270         
Gly Ala Gly Ser Ala Leu Leu Gly Thr Asp Val Gln Val Glu Ala Ala
        275                 280                 285             
Pro Ala Ala Leu Glu Leu Val Cys Pro Ser Ser Val Gln Ser Asp Glu
    290                 295                 300                 
Ser Leu Asp Leu Ser Ile Gln Asn Arg Gly Gly Ser Gly Leu Glu Ala
305                 310                 315                 320 
Ala Tyr Ser Ile Val Ala Leu Gly Glu Glu Pro Ala Arg Ala Val His
                325                 330                 335     
Pro Leu Cys Pro Ser Asp Thr Glu Ile Phe Pro Gly Asn Gly His Cys
            340                 345                 350         
Tyr Arg Leu Val Val Glu Lys Ala Ala Trp Leu Gln Ala Gln Glu Gln
        355                 360                 365             
Cys Gln Ala Trp Ala Gly Ala Ala Leu Ala Met Val Asp Ser Pro Ala
    370                 375                 380                 
Val Gln Arg Phe Leu Val Ser Arg Val Thr Arg Ser Leu Asp Val Trp
385                 390                 395                 400 
Ile Gly Phe Ser Thr Val Gln Gly Val Glu Val Gly Pro Ala Pro Gln
                405                 410                 415     
Gly Glu Ala Phe Ser Leu Glu Ser Cys Gln Asn Trp Leu Pro Gly Glu
            420                 425                 430         
Pro His Pro Ala Thr Ala Glu His Cys Val Arg Leu Gly Pro Thr Gly
        435                 440                 445             
Trp Cys Asn Thr Asp Leu Cys Ser Ala Pro His Ser Tyr Val Cys Glu
    450                 455                 460                 
Leu Gln Pro Gly Gly Pro Val Gln Asp Ala Glu Asn Leu Leu Val Gly
465                 470                 475                 480 
Ala Pro Ser Gly Asp Leu Gln Gly Pro Leu Thr Pro Leu Ala Gln Gln
                485                 490                 495     
Asp Gly Leu Ser Ala Pro His Glu Pro Val Glu Ala Gly Met Gly Ser
            500                 505                 510         
Val Glu Leu Arg Arg Pro Pro Ala His Gln Val Met Val Phe Pro Gly
        515                 520                 525             
Leu Arg Leu Ser Arg Glu Ala Phe Leu Thr Thr Ala Glu Phe Gly Thr
    530                 535                 540                 
Gln Glu Leu Arg Arg Pro Ala Gln Leu Arg Leu Gln Val Tyr Arg Leu
545                 550                 555                 560 
Leu Ser Thr Ala Gly Thr Pro Glu Asn Gly Ser Glu Pro Glu Ser Arg
                565                 570                 575     
Ser Pro Asp Asn Arg Thr Gln Leu Ala Pro Ala Cys Met Pro Gly Gly
            580                 585                 590         
Arg Trp Cys Pro Gly Ala Asn Ile Cys Leu Pro Leu Asp Ala Ser Cys
        595                 600                 605             
His Pro Gln Ala Cys Ala Asn Gly Cys Thr Glu Gly Glu His Val Val
    610                 615                 620                 
Asp Val Val Val Glu Asn Ser Ala Ser Arg Ala Asn Leu Ser Leu Arg
625                 630                 635                 640 
Val Thr Ala Glu Glu Pro Ile Cys Gly Leu Arg Ala Thr Pro Ser Pro
                645                 650                 655     
Glu Ala Arg Val Leu Gln Gly Val Leu Val Arg Tyr Ser Pro Val Val
            660                 665                 670         
Glu Ala Gly Ser Asp Met Val Phe Arg Trp Thr Ile Asn Asp Lys Gln
        675                 680                 685             
Ser Leu Thr Phe Gln Asn Val Val Phe Asn Val Ile Tyr Gln Ser Ala
    690                 695                 700                 
Ala Val Phe Lys Leu Ser Leu Thr Ala Ser Asn His Val Ser Asn Val
705                 710                 715                 720 
Thr Val Asn Tyr Asn Val Thr Val Glu Arg Met Asn Arg Met Gln Gly
                725                 730                 735     
Leu Gln Val Ser Thr Val Pro Ala Val Leu Ser Pro Asn Ala Thr Leu
            740                 745                 750         
Ala Leu Thr Ala Gly Val Leu Val Asp Ser Ala Val Glu Val Ala Phe
        755                 760                 765             
Leu Trp Thr Phe Gly Asp Gly Glu Gln Ala Leu His Gln Phe Gln Pro
    770                 775                 780                 
Pro Tyr Asn Glu Ser Phe Pro Val Pro Asp Pro Ser Val Ala Gln Val
785                 790                 795                 800 
Leu Val Glu His Asn Val Met His Thr Tyr Ala Ala Pro Gly Glu Tyr
                805                 810                 815     
Leu Leu Thr Val Leu Ala Ser Asn Ala Phe Glu Asn Arg Thr Gln Gln
            820                 825                 830         
Val Pro Val Ser Val Arg Ala Ser Leu Pro Ser Val Ala Val Gly Val
        835                 840                 845             
Ser Asp Gly Val Leu Ser Gln Pro Ala Ala Asn His Thr Tyr Ala Ser
    850                 855                 860                 
Arg Gly Thr Tyr His Val Arg Leu Glu Val Asn Asn Thr Val Ser Gly
865                 870                 875                 880 
Ala Ala Ala Gln Ala Asp Val Arg Val Phe Glu Glu Leu Arg Gly Leu
                885                 890                 895     
Ser Val Asp Met Ser Leu Ala Val Glu Gln Gly Ala Pro Val Val Val
            900                 905                 910         
Ser Ala Ala Val Gln Thr Gly Asp Asn Ile Thr Trp Thr Phe Asp Met
        915                 920                 925             
Gly Asp Gly Thr Val Leu Ser Gly Pro Glu Ala Thr Val Glu His Val
    930                 935                 940                 
Tyr Leu Arg Ala Gln Asn Cys Thr Val Thr Val Gly Ala Ala Ser Pro
945                 950                 955                 960 
Ala Gly His Leu Ala Arg Ser Leu His Val Leu Val Phe Val Leu Glu
                965                 970                 975     
Val Leu Arg Val Glu Pro Ala Ala Cys Ile Pro Thr Gln Pro Asp Ala
            980                 985                 990         
Arg Leu Thr Ala Tyr Val Thr Gly Asn Pro Ala His Tyr Leu Phe Asp
        995                 1000                1005            
Trp Thr Phe Gly Asp Gly Ser Ser Asn Thr Thr Val Arg Gly Cys Pro
    1010                1015                1020                
Thr Val Thr His Asn Phe Thr Arg Ser Gly Thr Phe Pro Leu Ala Leu
1025                1030                1035                1040
Val Leu Ser Ser Arg Val Asn Arg Ala His Tyr Phe Thr Ser Ile Cys
                1045                1050                1055    
Val Glu Pro Glu Val Gly Asn Val Thr Leu Gln Pro Glu Arg Gln Phe
            1060                1065                1070        
Val Gln Leu Gly Asp Glu Ala Trp Leu Val Ala Cys Ala Trp Pro Pro
        1075                1080                1085            
Phe Pro Tyr Arg Tyr Thr Trp Asp Phe Gly Thr Glu Glu Ala Ala Pro
    1090                1095                1100                
Thr Arg Ala Arg Gly Pro Glu Val Thr Phe Ile Tyr Arg Asp Pro Gly
1105                1110                1115                1120
Ser Tyr Leu Val Thr Val Thr Ala Ser Asn Asn Ile Ser Ala Ala Asn
                1125                1130                1135    
Asp Ser Ala Leu Val Glu Val Gln Glu Pro Val Leu Val Thr Ser Ile
            1140                1145                1150        
Lys Val Asn Gly Ser Leu Gly Leu Glu Leu Gln Gln Pro Tyr Leu Phe
        1155                1160                1165            
Ser Ala Val Gly Arg Gly Arg Pro Ala Ser Tyr Leu Trp Asp Leu Gly
    1170                1175                1180                
Asp Gly Gly Trp Leu Glu Gly Pro Glu Val Thr His Ala Tyr Asn Ser
1185                1190                1195                1200
Thr Gly Asp Phe Thr Gly Pro Gly Pro Gly Arg Gln Arg Gln Arg Leu
                1205                1210                1215    
Leu Ala His Arg Leu Glu Ala Gly Thr Tyr His Val Gln Leu Arg Ala
            1220                1225                1230        
Thr Asn Met Leu Gly Ser Ala Trp Ala Asp Cys Thr Met Asp Phe Val
        1235                1240                1245            
Glu Pro Val Gly Trp Leu Met Val Ala Ala Ser Pro Asn Pro Ala Ala
    1250                1255                1260                
Val Asn Lys Ser Val Thr Leu Ser Ala Glu Leu Ala Gly Gly Ser Gly
1265                1270                1275                1280
Val Val Tyr Thr Trp Ser Leu Glu Glu Gly Leu Ser Trp Glu Thr Ser
                1285                1290                1295    
Glu Pro Phe Thr Thr His Ser Phe Pro Thr Pro Gly Leu His Leu Val
            1300                1305                1310        
Thr Met Thr Ala Gly Asn Pro Leu Gly Ser Ala Asn Ala Thr Val Glu
        1315                1320                1325            
Val Asp Val Gln Val Pro Val Ser Gly Leu Ser Ile Arg Ala Ser Glu
    1330                1335                1340                
Pro Gly Gly Ser Phe Val Ala Ala Gly Ser Ser Val Pro Phe Trp Gly
1345                1350                1355                1360
Gln Leu Ala Thr Gly Thr Asn Val Ser Trp Cys Trp Ala Val Pro Gly
                1365                1370                1375    
Gly Ser Ser Lys Arg Gly Pro His Val Thr Met Val Phe Pro Asp Ala
            1380                1385                1390        
Gly Thr Phe Ser Ile Arg Leu Asn Ala Ser Asn Ala Val Ser Trp Val
        1395                1400                1405            
Ser Ala Thr Tyr Asn Leu Thr Ala Glu Glu Pro Ile Val Gly Leu Val
    1410                1415                1420                
Leu Trp Ala Ser Ser Lys Val Val Ala Pro Gly Gln Leu Val His Phe
1425                1430                1435                1440
Gln Ile Leu Leu Ala Ala Gly Ser Ala Val Thr Phe Arg Leu Gln Asp
                1445                1450                1455    
Thr Asp Glu Pro Arg Ala Glu His Ser Tyr Leu Arg Pro Gly Asp Tyr
            1460                1465                1470        
Arg Val Gln Val Asn Ala Ser Asn Leu Val Ser Phe Phe Val Ala Gln
        1475                1480                1485            
Ala Thr Val Thr Val Gln Val Leu Ala Cys Arg Glu Pro Glu Val Asp
    1490                1495                1500                
Val Val Leu Pro Leu Gln Val Leu Met Arg Arg Ser Gln Arg Asn Tyr
1505                1510                1515                1520
Leu Glu Ala His Val Asp Leu Arg Asp Cys Val Thr Tyr Gln Thr Glu
                1525                1530                1535    
Tyr Arg Trp Glu Val Tyr Arg Thr Ala Ser Cys Gln Arg Pro Gly Arg
            1540                1545                1550        
Pro Ala Arg Val Ala Leu Pro Gly Val Asp Val Ser Arg Pro Arg Leu
        1555                1560                1565            
Val Leu Pro Arg Leu Ala Leu Pro Val Gly His Tyr Cys Phe Val Phe
    1570                1575                1580                
Val Val Ser Phe Gly Asp Thr Pro Leu Thr Gln Ser Ile Gln Ala Asn
1585                1590                1595                1600
Val Thr Val Ala Pro Glu Arg Leu Val Pro Ile Ile Glu Gly Gly Ser
                1605                1610                1615    
Tyr Arg Val Trp Ser Asp Thr Arg Asp Leu Val Leu Asp Gly Ser Glu
            1620                1625                1630        
Ser Tyr Asp Pro Asn Leu Glu Asp Gly Asp Gln Thr Pro Leu Ser Phe
        1635                1640                1645            
His Trp Ala Cys Val Ala Ser Thr Gln Arg Glu Ala Gly Gly Cys Ala
    1650                1655                1660                
Leu Asn Phe Gly Pro Arg Gly Ser Ser Thr Val Thr Ile Pro Arg Glu
1665                1670                1675                1680
Arg Leu Ala Ala Gly Val Glu Tyr Thr Phe Ser Leu Thr Val Trp Lys
                1685                1690                1695    
Ala Gly Arg Lys Glu Glu Ala Thr Asn Gln Thr Val Leu Ile Arg Ser
            1700                1705                1710        
Gly Arg Val Pro Ile Val Ser Leu Glu Cys Val Ser Cys Lys Ala Gln
        1715                1720                1725            
Ala Val Tyr Glu Val Ser Arg Ser Ser Tyr Val Tyr Leu Glu Gly Arg
    1730                1735                1740                
Cys Leu Asn Cys Ser Ser Gly Ser Lys Arg Gly Arg Trp Ala Ala Arg
1745                1750                1755                1760
Thr Phe Ser Asn Lys Thr Leu Val Leu Asp Glu Thr Thr Thr Ser Thr
                1765                1770                1775    
Gly Ser Ala Gly Met Arg Leu Val Leu Arg Arg Gly Val Leu Arg Asp
            1780                1785                1790        
Gly Glu Gly Tyr Thr Phe Thr Leu Thr Val Leu Gly Arg Ser Gly Glu
        1795                1800                1805            
Glu Glu Gly Cys Ala Ser Ile Arg Leu Ser Pro Asn Arg Pro Pro Leu
    1810                1815                1820                
Gly Gly Ser Cys Arg Leu Phe Pro Leu Gly Ala Val His Ala Leu Thr
1825                1830                1835                1840
Thr Lys Val His Phe Glu Cys Thr Gly Trp His Asp Ala Glu Asp Ala
                1845                1850                1855    
Gly Ala Pro Leu Val Tyr Ala Leu Leu Leu Arg Arg Cys Arg Gln Gly
            1860                1865                1870        
His Cys Glu Glu Phe Cys Val Tyr Lys Gly Ser Leu Ser Ser Tyr Gly
        1875                1880                1885            
Ala Val Leu Pro Pro Gly Phe Arg Pro His Phe Glu Val Gly Leu Ala
    1890                1895                1900                
Val Val Val Gln Asp Gln Leu Gly Ala Ala Val Val Ala Leu Asn Arg
1905                1910                1915                1920
Ser Leu Ala Ile Thr Leu Pro Glu Pro Asn Gly Ser Ala Thr Gly Leu
                1925                1930                1935    
Thr Val Trp Leu His Gly Leu Thr Ala Ser Val Leu Pro Gly Leu Leu
            1940                1945                1950        
Arg Gln Ala Asp Pro Gln His Val Ile Glu Tyr Ser Leu Ala Leu Val
        1955                1960                1965            
Thr Val Leu Asn Glu His Arg Ala Gln Ile Arg Lys Asn Ile Thr Glu
    1970                1975                1980                
Thr Leu Val Ser Leu Arg Val His Thr Val Asp Asp Ile Gln Gln Ile
1985                1990                1995                2000
Ala Ala Ala Leu Ala Gln Cys Met Gly Pro Ser Arg Glu Leu Val Cys
                2005                2010                2015    
Arg Ser Cys Leu Lys Gln Thr Leu His Lys Leu Glu Ala Met Met Leu
            2020                2025                2030        
Ile Leu Gln Ala Glu Thr Thr Ala Gly Thr Val Thr Pro Thr Ala Ile
        2035                2040                2045            
Gly Asp Ser Ile Leu Asn Ile Thr Gly Asp Leu Ile His Leu Ala Ser
    2050                2055                2060                
Ser Asp Val Arg Ala Pro Gln Pro Ser Glu Leu Gly Ala Glu Ser Pro
2065                2070                2075                2080
Ser Arg Met Val Ala Ser Gln Ala Tyr Asn Leu Thr Ser Ala Leu Met
                2085                2090                2095    
Arg Ile Leu Met Arg Ser Arg Val Leu Asn Glu Glu Pro Leu Thr Leu
            2100                2105                2110        
Ala Gly Glu Glu Ile Val Ala Gln Gly Lys Arg Ser Asp Pro Arg Ser
        2115                2120                2125            
Leu Leu Cys Tyr Gly Gly Ala Pro Gly Pro Gly Cys His Phe Ser Ile
    2130                2135                2140                
Pro Glu Ala Phe Ser Gly Ala Leu Ala Asn Leu Ser Asp Val Val Gln
2145                2150                2155                2160
Leu Ile Phe Leu Val Asp Ser Asn Pro Phe Pro Phe Gly Tyr Ile Ser
                2165                2170                2175    
Asn Tyr Thr Val Ser Thr Lys Val Ala Ser Met Ala Phe Gln Thr Gln
            2180                2185                2190        
Ala Gly Ala Gln Ile Pro Ile Glu Arg Leu Ala Ser Glu Arg Ala Ile
        2195                2200                2205            
Thr Val Lys Val Pro Asn Asn Ser Asp Trp Ala Ala Arg Gly His Arg
    2210                2215                2220                
Ser Ser Ala Asn Ser Ala Asn Ser Val Val Val Gln Pro Gln Ala Ser
2225                2230                2235                2240
Val Gly Ala Val Val Thr Leu Asp Ser Ser Asn Pro Ala Ala Gly Leu
                2245                2250                2255    
His Leu Gln Leu Asn Tyr Thr Leu Leu Asp Gly His Tyr Leu Ser Glu
            2260                2265                2270        
Glu Pro Glu Pro Tyr Leu Ala Val Tyr Leu His Ser Glu Pro Arg Pro
        2275                2280                2285            
Asn Glu His Asn Cys Ser Ala Ser Arg Arg Ile Arg Pro Glu Ser Leu
    2290                2295                2300                
Gln Gly Ala Asp His Arg Pro Tyr Thr Phe Phe Ile Ser Pro Gly Ser
2305                2310                2315                2320
Arg Asp Pro Ala Gly Ser Tyr His Leu Asn Leu Ser Ser His Phe Arg
                2325                2330                2335    
Trp Ser Ala Leu Gln Val Ser Val Gly Leu Tyr Thr Ser Leu Cys Gln
            2340                2345                2350        
Tyr Phe Ser Glu Glu Asp Met Val Trp Arg Thr Glu Gly Leu Leu Pro
        2355                2360                2365            
Leu Glu Glu Thr Ser Pro Arg Gln Ala Val Cys Leu Thr Arg His Leu
    2370                2375                2380                
Thr Ala Phe Gly Ala Ser Leu Phe Val Pro Pro Ser His Val Arg Phe
2385                2390                2395                2400
Val Phe Pro Glu Pro Thr Ala Asp Val Asn Tyr Ile Val Met Leu Thr
                2405                2410                2415    
Cys Ala Val Cys Leu Val Thr Tyr Met Val Met Ala Ala Ile Leu His
            2420                2425                2430        
Lys Leu Asp Gln Leu Asp Ala Ser Arg Gly Arg Ala Ile Pro Phe Cys
        2435                2440                2445            
Gly Gln Arg Gly Arg Phe Lys Tyr Glu Ile Leu Val Lys Thr Gly Trp
    2450                2455                2460                
Gly Arg Gly Ser Gly Thr Thr Ala His Val Gly Ile Met Leu Tyr Gly
2465                2470                2475                2480
Val Asp Ser Arg Ser Gly His Arg His Leu Asp Gly Asp Arg Ala Phe
                2485                2490                2495    
His Arg Asn Ser Leu Asp Ile Phe Arg Ile Ala Thr Pro His Ser Leu
            2500                2505                2510        
Gly Ser Val Trp Lys Ile Arg Val Trp His Asp Asn Lys Gly Leu Ser
        2515                2520                2525            
Pro Ala Trp Phe Leu Gln His Val Ile Val Arg Asp Leu Gln Thr Ala
    2530                2535                2540                
Arg Ser Ala Phe Phe Leu Val Asn Asp Trp Leu Ser Val Glu Thr Glu
2545                2550                2555                2560
Ala Asn Gly Gly Leu Val Glu Lys Glu Val Leu Ala Ala Ser Asp Ala
                2565                2570                2575    
Ala Leu Leu Arg Phe Arg Arg Leu Leu Val Ala Glu Leu Gln Arg Gly
            2580                2585                2590        
Phe Phe Asp Lys His Ile Trp Leu Ser Ile Trp Asp Arg Pro Pro Arg
        2595                2600                2605            
Ser Arg Phe Thr Arg Ile Gln Arg Ala Thr Cys Cys Val Leu Leu Ile
    2610                2615                2620                
Cys Leu Phe Leu Gly Ala Asn Ala Val Trp Tyr Gly Ala Val Gly Asp
2625                2630                2635                2640
Ser Ala Tyr Ser Thr Gly His Val Ser Arg Leu Ser Pro Leu Ser Val
                2645                2650                2655    
Asp Thr Val Ala Val Gly Leu Val Ser Ser Val Val Val Tyr Pro Val
            2660                2665                2670        
Tyr Leu Ala Ile Leu Phe Leu Phe Arg Met Ser Arg Ser Lys Val Ala
        2675                2680                2685            
Gly Ser Pro Ser Pro Thr Pro Ala Gly Gln Gln Val Leu Asp Ile Asp
    2690                2695                2700                
Ser Cys Leu Asp Ser Ser Val Leu Asp Ser Ser Phe Leu Thr Phe Ser
2705                2710                2715                2720
Gly Leu His Ala Glu Ala Phe Val Gly Gln Met Lys Ser Asp Leu Phe
                2725                2730                2735    
Leu Asp Asp Ser Lys Ser Leu Val Cys Trp Pro Ser Gly Glu Gly Thr
            2740                2745                2750        
Leu Ser Trp Pro Asp Leu Leu Ser Asp Pro Ser Ile Val Gly Ser Asn
        2755                2760                2765            
Leu Arg Gln Leu Ala Arg Gly Gln Ala Gly His Gly Leu Gly Pro Glu
    2770                2775                2780                
Glu Asp Gly Phe Ser Leu Ala Ser Pro Tyr Ser Pro Ala Lys Ser Phe
2785                2790                2795                2800
Ser Ala Ser Asp Glu Asp Leu Ile Gln Gln Val Leu Ala Glu Gly Val
                2805                2810                2815    
Ser Ser Pro Ala Pro Thr Gln Asp Thr His Met Glu Thr Asp Leu Leu
            2820                2825                2830        
Ser Ser Leu Ser Ser Thr Pro Gly Glu Lys Thr Glu Thr Leu Ala Leu
        2835                2840                2845            
Gln Arg Leu Gly Glu Leu Gly Pro Pro Ser Pro Gly Leu Asn Trp Glu
    2850                2855                2860                
Gln Pro Gln Ala Ala Arg Leu Ser Arg Thr Gly Leu Val Glu Gly Leu
2865                2870                2875                2880
Arg Lys Arg Leu Leu Pro Ala Trp Cys Ala Ser Leu Ala His Gly Leu
                2885                2890                2895    
Ser Leu Leu Leu Val Ala Val Ala Val Ala Val Ser Gly Trp Val Gly
            2900                2905                2910        
Ala Ser Phe Pro Pro Gly Val Ser Val Ala Trp Leu Leu Ser Ser Ser
        2915                2920                2925            
Ala Ser Phe Leu Ala Ser Phe Leu Gly Trp Glu Pro Leu Lys Val Leu
    2930                2935                2940                
Leu Glu Ala Leu Tyr Phe Ser Leu Val Ala Lys Arg Leu His Pro Asp
2945                2950                2955                2960
Glu Asp Asp Thr Leu Val Glu Ser Pro Ala Val Thr Pro Val Ser Ala
                2965                2970                2975    
Arg Val Pro Arg Val Arg Pro Pro His Gly Phe Ala Leu Phe Leu Ala
            2980                2985                2990        
Lys Glu Glu Ala Arg Lys Val Lys Arg Leu His Gly Met Leu Arg Ser
        2995                3000                3005            
Leu Leu Val Tyr Met Leu Phe Leu Leu Val Thr Leu Leu Ala Ser Tyr
    3010                3015                3020                
Gly Asp Ala Ser Cys His Gly His Ala Tyr Arg Leu Gln Ser Ala Ile
3025                3030                3035                3040
Lys Gln Glu Leu His Ser Arg Ala Phe Leu Ala Ile Thr Arg Ser Glu
                3045                3050                3055    
Glu Leu Trp Pro Trp Met Ala His Val Leu Leu Pro Tyr Val His Gly
            3060                3065                3070        
Asn Gln Ser Ser Pro Glu Leu Gly Pro Pro Arg Leu Arg Gln Val Arg
        3075                3080                3085            
Leu Gln Glu Ala Leu Tyr Pro Asp Pro Pro Gly Pro Arg Val His Thr
    3090                3095                3100                
Cys Ser Ala Ala Gly Gly Phe Ser Thr Ser Asp Tyr Asp Val Gly Trp
3105                3110                3115                3120
Glu Ser Pro His Asn Gly Ser Gly Thr Trp Ala Tyr Ser Ala Pro Asp
                3125                3130                3135    
Leu Leu Gly Ala Trp Ser Trp Gly Ser Cys Ala Val Tyr Asp Ser Gly
            3140                3145                3150        
Gly Tyr Val Gln Glu Leu Gly Leu Ser Leu Glu Glu Ser Arg Asp Arg
        3155                3160                3165            
Leu Arg Phe Leu Gln Leu His Asn Trp Leu Asp Asn Arg Ser Arg Ala
    3170                3175                3180                
Val Phe Leu Glu Leu Thr Arg Tyr Ser Pro Ala Val Gly Leu His Ala
3185                3190                3195                3200
Ala Val Thr Leu Arg Leu Glu Phe Pro Ala Ala Gly Arg Ala Leu Ala
                3205                3210                3215    
Ala Leu Ser Val Arg Pro Phe Ala Leu Arg Arg Leu Ser Ala Gly Leu
            3220                3225                3230        
Ser Leu Pro Leu Leu Thr Ser Val Cys Leu Leu Leu Phe Ala Val His
        3235                3240                3245            
Phe Ala Val Ala Glu Ala Arg Thr Trp His Arg Glu Gly Arg Trp Arg
    3250                3255                3260                
Val Leu Arg Leu Gly Ala Trp Ala Arg Trp Leu Leu Val Ala Leu Thr
3265                3270                3275                3280
Ala Ala Thr Ala Leu Val Arg Leu Ala Gln Leu Gly Ala Ala Asp Arg
                3285                3290                3295    
Gln Trp Thr Arg Phe Val Arg Gly Arg Pro Arg Arg Phe Thr Ser Phe
            3300                3305                3310        
Asp Gln Val Ala Gln Leu Ser Ser Ala Ala Arg Gly Leu Ala Ala Ser
        3315                3320                3325            
Leu Leu Phe Leu Leu Leu Val Lys Ala Ala Gln Gln Leu Arg Phe Val
    3330                3335                3340                
Arg Gln Trp Ser Val Phe Gly Lys Thr Leu Cys Arg Ala Leu Pro Glu
3345                3350                3355                3360
Leu Leu Gly Val Thr Leu Gly Leu Val Val Leu Gly Val Ala Tyr Ala
                3365                3370                3375    
Gln Leu Ala Ile Leu Leu Val Ser Ser Cys Val Asp Ser Leu Trp Ser
            3380                3385                3390        
Val Ala Gln Ala Leu Leu Val Leu Cys Pro Gly Thr Gly Leu Ser Thr
        3395                3400                3405            
Leu Cys Pro Ala Glu Ser Trp His Leu Ser Pro Leu Leu Cys Val Gly
    3410                3415                3420                
Leu Trp Ala Leu Arg Leu Trp Gly Ala Leu Arg Leu Gly Ala Val Ile
3425                3430                3435                3440
Leu Arg Trp Arg Tyr His Ala Leu Arg Gly Glu Leu Tyr Arg Pro Ala
                3445                3450                3455    
Trp Glu Pro Gln Asp Tyr Glu Met Val Glu Leu Phe Leu Arg Arg Leu
            3460                3465                3470        
Arg Leu Trp Met Gly Leu Ser Lys Val Lys Glu Phe Arg His Lys Val
        3475                3480                3485            
Arg Phe Glu Gly Met Glu Pro Leu Pro Ser Arg Ser Ser Arg Gly Ser
    3490                3495                3500                
Lys Val Ser Pro Asp Val Pro Pro Pro Ser Ala Gly Ser Asp Ala Ser
3505                3510                3515                3520
His Pro Ser Thr Ser Ser Ser Gln Leu Asp Gly Leu Ser Val Ser Leu
                3525                3530                3535    
Gly Arg Leu Gly Thr Arg Cys Glu Pro Glu Pro Ser Arg Leu Gln Ala
            3540                3545                3550        
Val Phe Glu Ala Leu Leu Thr Gln Phe Asp Arg Leu Asn Gln Ala Thr
        3555                3560                3565            
Glu Asp Val Tyr Gln Leu Glu Gln Gln Leu His Ser Leu Gln Gly Arg
    3570                3575                3580                
Arg Ser Ser Arg Ala Pro Ala Gly Ser Ser Arg Gly Pro Ser Pro Gly
3585                3590                3595                3600
Leu Arg Pro Ala Leu Pro Ser Arg Leu Ala Arg Ala Ser Arg Gly Val
                3605                3610                3615    
Asp Leu Ala Thr Gly Pro Ser Arg Thr Pro Leu Arg Ala Lys Asn Lys
            3620                3625                3630        
Val His Pro Ser Ser Thr
        3635            


<210> 9206
<211> 435
<212> PRT
<213> Homo sapiens

<400> 9206
Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile Phe Cys
 1               5                  10                  15      
Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu
            20                  25                  30          
Cys Ala Pro Ile Tyr Cys Val Ser Leu Ala Asn Ala Pro Ser Ala Tyr
        35                  40                  45              
Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser
    50                  55                  60                  
Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu
65                  70                  75                  80  
Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Val Ser Val Ser Thr Ser
                85                  90                  95      
Leu Ala Met Leu Ser Leu Gly Ala His Ser Val Thr Lys Thr Gln Ile
            100                 105                 110         
Leu Gln Gly Leu Gly Phe Asn Leu Thr His Thr Pro Glu Ser Ala Ile
        115                 120                 125             
His Gln Gly Phe Gln His Leu Val His Ser Leu Thr Val Pro Ser Lys
    130                 135                 140                 
Asp Leu Thr Leu Lys Met Gly Ser Ala Leu Phe Val Lys Lys Glu Leu
145                 150                 155                 160 
Gln Leu Gln Ala Asn Phe Leu Gly Asn Val Lys Arg Leu Tyr Glu Ala
                165                 170                 175     
Glu Val Phe Ser Thr Asp Phe Ser Asn Pro Ser Ile Ala Gln Ala Arg
            180                 185                 190         
Ile Asn Ser His Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile
        195                 200                 205             
Ile Gln Gly Leu Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile
    210                 215                 220                 
Phe Phe Lys Ala Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg
225                 230                 235                 240 
Lys Asp Phe Pro Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro
                245                 250                 255     
Met Met His Gln Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu
            260                 265                 270         
Asn Cys Phe Val Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe
        275                 280                 285             
Phe Val Leu Pro Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu
    290                 295                 300                 
Ser Ala Arg Thr Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp
305                 310                 315                 320 
Ile Glu Val Phe Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu
                325                 330                 335     
Glu Thr Ile Leu Pro Lys Met Gly Ile Gln Asn Ala Phe Asp Lys Asn
            340                 345                 350         
Ala Asp Phe Ser Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys
        355                 360                 365             
Ala Thr His Lys Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala
    370                 375                 380                 
Thr Ala Ala Thr Ala Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro
385                 390                 395                 400 
Ser Tyr Phe Thr Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr
                405                 410                 415     
Asn Lys Ala Thr Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro
            420                 425                 430         
Thr Lys Ser
        435 


<210> 9207
<211> 335
<212> PRT
<213> Homo sapiens

<400> 9207
Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile Phe Cys
 1               5                  10                  15      
Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu
            20                  25                  30          
Cys Ala Pro Ile Tyr Cys Val Ser Leu Ala Asn Ala Pro Ser Ala Tyr
        35                  40                  45              
Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser
    50                  55                  60                  
Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu
65                  70                  75                  80  
Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Ala Arg Ile Asn Ser His
                85                  90                  95      
Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile Ile Gln Gly Leu
            100                 105                 110         
Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile Phe Phe Lys Ala
        115                 120                 125             
Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg Lys Asn Phe Pro
    130                 135                 140                 
Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro Met Met His Gln
145                 150                 155                 160 
Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu Asn Cys Phe Val
                165                 170                 175     
Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe Phe Val Leu Pro
            180                 185                 190         
Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu Ser Ala Arg Thr
        195                 200                 205             
Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp Ile Glu Val Phe
    210                 215                 220                 
Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu Glu Thr Ile Leu
225                 230                 235                 240 
Pro Lys Met Gly Ile Gln Asn Ala Phe Asp Lys Asn Ala Asp Phe Ser
                245                 250                 255     
Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys Ala Thr His Lys
            260                 265                 270         
Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Thr Ala Ala Thr
        275                 280                 285             
Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro Ser Tyr Phe Thr
    290                 295                 300                 
Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr Asn Lys Ala Thr
305                 310                 315                 320 
Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro Thr Lys Ser
                325                 330                 335 


<210> 9208
<211> 524
<212> PRT
<213> Homo sapiens

<400> 9208
Met Ser Leu Leu Ser Leu Pro Trp Leu Gly Leu Arg Pro Val Ala Met
 1               5                  10                  15      
Ser Pro Trp Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala
            20                  25                  30          
Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu
        35                  40                  45              
Gln Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu
    50                  55                  60                  
Gly Leu Ile Thr Pro Thr Glu Glu Gly Leu Lys Asp Ser Thr Gln Met
65                  70                  75                  80  
Ser Ala Thr Tyr Ser Gln Gly Phe Thr Val Trp Leu Gly Pro Ile Ile
                85                  90                  95      
Pro Phe Ile Val Leu Cys His Pro Asp Thr Ile Arg Ser Ile Thr Asn
            100                 105                 110         
Ala Ser Ala Ala Ile Ala Pro Lys Asp Asn Leu Phe Ile Arg Phe Leu
        115                 120                 125             
Lys Pro Trp Leu Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp
    130                 135                 140                 
Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu
145                 150                 155                 160 
Lys Ser Tyr Ile Thr Ile Phe Asn Lys Ser Ala Asn Ile Met Leu Asp
                165                 170                 175     
Lys Trp Gln His Leu Ala Ser Glu Gly Ser Ser Arg Leu Asp Met Phe
            180                 185                 190         
Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe
        195                 200                 205             
Ser Phe Asp Ser His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr
    210                 215                 220                 
Ile Leu Glu Leu Ser Ala Leu Val Glu Lys Arg Ser Gln His Ile Leu
225                 230                 235                 240 
Gln His Met Asp Phe Leu Tyr Tyr Leu Ser His Asp Gly Arg Arg Phe
                245                 250                 255     
His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Arg
            260                 265                 270         
Glu Arg Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Phe Lys
        275                 280                 285             
Asp Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu
    290                 295                 300                 
Ser Lys Asp Glu Asp Gly Lys Ala Leu Ser Asp Glu Asp Ile Arg Ala
305                 310                 315                 320 
Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly
                325                 330                 335     
Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu
            340                 345                 350         
Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Asp Pro Lys
        355                 360                 365             
Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys
    370                 375                 380                 
Val Lys Glu Ser Leu Arg Leu His Pro Pro Ala Pro Phe Ile Ser Arg
385                 390                 395                 400 
Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys
                405                 410                 415     
Gly Ile Thr Cys Leu Ile Asp Ile Ile Gly Val His His Asn Pro Thr
            420                 425                 430         
Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu
        435                 440                 445             
Asn Ser Lys Gly Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly
    450                 455                 460                 
Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val
465                 470                 475                 480 
Val Leu Ala Leu Met Leu Leu His Phe Arg Phe Leu Pro Asp His Thr
                485                 490                 495     
Glu Pro Arg Arg Lys Leu Glu Leu Ile Met Arg Ala Glu Gly Gly Leu
            500                 505                 510         
Trp Leu Arg Val Glu Pro Leu Asn Val Gly Leu Gln
        515                 520                 


<210> 9209
<211> 259
<212> PRT
<213> Homo sapiens

<400> 9209
Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala
 1               5                  10                  15      
Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu
            20                  25                  30          
Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe
        35                  40                  45              
Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly
    50                  55                  60                  
Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn
65                  70                  75                  80  
Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys
                85                  90                  95      
His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys
            100                 105                 110         
Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys
        115                 120                 125             
Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp
    130                 135                 140                 
Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu
145                 150                 155                 160 
Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala
                165                 170                 175     
Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro
            180                 185                 190         
Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala
        195                 200                 205             
Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala
    210                 215                 220                 
Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr
225                 230                 235                 240 
Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile
                245                 250                 255     
Val Phe Val
            


<210> 9210
<211> 442
<212> PRT
<213> Homo sapiens

<400> 9210
Met Asp Val Lys Glu Arg Arg Pro Tyr Cys Ser Leu Thr Lys Ser Arg
 1               5                  10                  15      
Arg Glu Lys Glu Arg Arg Tyr Thr Asn Ser Ser Ala Asp Asn Glu Glu
            20                  25                  30          
Cys Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys
        35                  40                  45              
Ala Phe Asp His Asp Ser Ser Arg Leu Leu Tyr Gly Asn Arg Val Lys
    50                  55                  60                  
Asp Leu Val His Arg Glu Ala Asp Glu Phe Thr Arg Gln Gly Gln Asn
65                  70                  75                  80  
Phe Thr Leu Arg Gln Leu Gly Val Cys Glu Pro Ala Thr Arg Arg Gly
                85                  90                  95      
Leu Ala Phe Cys Ala Glu Met Gly Leu Pro His Arg Gly Tyr Ser Ile
            100                 105                 110         
Ser Ala Gly Ser Asp Ala Asp Thr Glu Asn Glu Ala Val Met Ser Pro
        115                 120                 125             
Glu His Ala Met Arg Leu Trp Gly Arg Gly Val Lys Ser Gly Arg Ser
    130                 135                 140                 
Ser Cys Leu Ser Ser Arg Ser Asn Ser Ala Leu Thr Leu Thr Asp Thr
145                 150                 155                 160 
Glu His Glu Asn Lys Ser Asp Ser Glu Asn Glu Gln Pro Ala Ser Asn
                165                 170                 175     
Gln Gly Gln Ser Thr Leu Gln Pro Leu Pro Pro Ser His Lys Gln His
            180                 185                 190         
Ser Ala Gln His His Pro Ser Ile Thr Ser Leu Asn Arg Asn Ser Leu
        195                 200                 205             
Thr Asn Arg Arg Asn Gln Ser Pro Ala Pro Pro Ala Ala Leu Pro Ala
    210                 215                 220                 
Glu Leu Gln Thr Thr Pro Glu Ser Val Gln Leu Gln Asp Ser Trp Val
225                 230                 235                 240 
Leu Gly Ser Asn Val Pro Leu Glu Ser Arg His Phe Leu Phe Lys Thr
                245                 250                 255     
Gly Thr Gly Thr Thr Pro Leu Phe Ser Thr Ala Thr Pro Gly Tyr Thr
            260                 265                 270         
Met Ala Ser Gly Ser Val Tyr Ser Pro Pro Thr Arg Pro Leu Pro Arg
        275                 280                 285             
Asn Thr Leu Ser Arg Ser Ala Phe Lys Phe Lys Lys Ser Ser Lys Tyr
    290                 295                 300                 
Cys Ser Trp Lys Cys Thr Ala Leu Cys Ala Val Gly Val Ser Val Leu
305                 310                 315                 320 
Leu Ala Ile Leu Leu Ser Tyr Phe Ile Ala Met His Leu Phe Gly Leu
                325                 330                 335     
Asn Trp Gln Leu Gln Gln Thr Glu Asn Asp Thr Phe Glu Asn Gly Lys
            340                 345                 350         
Val Asn Ser Asp Thr Met Pro Thr Asn Thr Val Ser Leu Pro Ser Gly
        355                 360                 365             
Asp Asn Gly Lys Leu Gly Gly Phe Thr Gln Glu Asn Asn Thr Ile Asp
    370                 375                 380                 
Ser Gly Glu Leu Asp Ile Gly Arg Arg Ala Ile Gln Glu Ile Pro Pro
385                 390                 395                 400 
Gly Ile Phe Trp Arg Ser Gln Leu Phe Ile Asp Gln Pro Gln Phe Leu
                405                 410                 415     
Lys Phe Asn Ile Ser Leu Gln Lys Asp Ala Leu Ile Gly Val Tyr Gly
            420                 425                 430         
Arg Lys Lys Leu Pro Pro Ser His Thr Gln
        435                 440         


<210> 9211
<211> 530
<212> PRT
<213> Homo sapiens

<400> 9211
Met Ser Arg Ser Pro Gln Arg Ala Leu Pro Pro Gly Ala Leu Pro Arg
 1               5                  10                  15      
Leu Leu Gln Ala Ala Pro Ala Ala Ala Pro Arg Ala Leu Leu Pro Gln
            20                  25                  30          
Trp Pro Arg Arg Pro Gly Arg Arg Trp Pro Ala Ser Pro Leu Gly Met
        35                  40                  45              
Lys Val Phe Arg Arg Lys Ala Leu Val Leu Cys Ala Gly Tyr Ala Leu
    50                  55                  60                  
Leu Leu Val Leu Thr Met Leu Asn Leu Leu Asp Tyr Lys Trp His Lys
65                  70                  75                  80  
Glu Pro Leu Gln Gln Cys Asn Pro Asp Gly Pro Leu Gly Ala Ala Ala
                85                  90                  95      
Gly Ala Ala Gly Gly Ser Trp Gly Arg Pro Gly Pro Pro Pro Ala Gly
            100                 105                 110         
Pro Pro Arg Ala His Ala Arg Leu Asp Leu Arg Thr Pro Tyr Arg Pro
        115                 120                 125             
Pro Ala Ala Ala Val Gly Ala Ala Pro Ala Ala Ala Ala Gly Met Ala
    130                 135                 140                 
Gly Val Ala Ala Pro Pro Gly Asn Gly Thr Arg Gly Thr Gly Gly Val
145                 150                 155                 160 
Gly Asp Lys Arg Gln Leu Val Tyr Val Phe Thr Thr Trp Arg Ser Gly
                165                 170                 175     
Ser Ser Phe Phe Gly Glu Leu Phe Asn Gln Asn Pro Glu Val Phe Phe
            180                 185                 190         
Leu Tyr Glu Pro Val Trp His Val Trp Gln Lys Leu Tyr Pro Gly Asp
        195                 200                 205             
Ala Val Ser Leu Gln Gly Ala Ala Arg Asp Met Leu Ser Ala Leu Tyr
    210                 215                 220                 
Arg Cys Asp Leu Ser Val Phe Gln Leu Tyr Ser Pro Ala Gly Ser Gly
225                 230                 235                 240 
Gly Arg Asn Leu Thr Thr Leu Gly Ile Phe Gly Ala Ala Thr Asn Lys
                245                 250                 255     
Val Val Cys Ser Ser Pro Leu Cys Pro Ala Tyr Arg Lys Glu Val Val
            260                 265                 270         
Gly Leu Val Asp Asp Arg Val Cys Lys Lys Cys Pro Pro Gln Arg Leu
        275                 280                 285             
Ala Arg Phe Glu Glu Glu Cys Arg Lys Tyr Arg Thr Leu Val Ile Lys
    290                 295                 300                 
Gly Val Arg Val Phe Asp Val Ala Val Leu Ala Pro Leu Leu Arg Asp
305                 310                 315                 320 
Pro Ala Leu Asp Leu Lys Val Ile His Leu Val Arg Asp Pro Arg Ala
                325                 330                 335     
Val Ala Ser Ser Arg Ile Arg Ser Arg His Gly Leu Ile Arg Glu Ser
            340                 345                 350         
Leu Gln Val Val Arg Ser Arg Asp Pro Arg Ala His Arg Met Pro Phe
        355                 360                 365             
Leu Glu Ala Ala Gly His Lys Leu Gly Ala Lys Lys Glu Gly Val Gly
    370                 375                 380                 
Gly Pro Ala Asp Tyr His Ala Leu Gly Ala Met Glu Val Ile Cys Asn
385                 390                 395                 400 
Ser Met Ala Lys Thr Leu Gln Thr Ala Leu Gln Pro Pro Asp Trp Leu
                405                 410                 415     
Gln Gly His Tyr Leu Val Val Arg Tyr Glu Asp Leu Val Gly Asp Pro
            420                 425                 430         
Val Lys Thr Leu Arg Arg Val Tyr Asp Phe Val Gly Leu Leu Val Ser
        435                 440                 445             
Pro Glu Met Glu Gln Phe Ala Leu Asn Met Thr Ser Gly Ser Gly Ser
    450                 455                 460                 
Ser Ser Lys Pro Phe Val Val Ser Ala Arg Asn Ala Thr Gln Ala Ala
465                 470                 475                 480 
Asn Ala Trp Arg Thr Ala Leu Thr Phe Gln Gln Ile Lys Gln Val Glu
                485                 490                 495     
Glu Phe Cys Tyr Gln Pro Met Ala Val Leu Gly Tyr Glu Arg Val Asn
            500                 505                 510         
Ser Pro Glu Glu Val Lys Asp Leu Ser Lys Thr Leu Leu Arg Lys Pro
        515                 520                 525             
Arg Leu
    530 


<210> 9212
<211> 2505
<212> PRT
<213> Homo sapiens

<400> 9212
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly
            20                  25                  30          
Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr
        35                  40                  45              
Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro
    50                  55                  60                  
Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu
65                  70                  75                  80  
Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu
                85                  90                  95      
Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys
            100                 105                 110         
Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro
        115                 120                 125             
Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe
    130                 135                 140                 
Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His
145                 150                 155                 160 
Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val
                165                 170                 175     
Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg
            180                 185                 190         
Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly
        195                 200                 205             
Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile
    210                 215                 220                 
Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe
225                 230                 235                 240 
Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys
                245                 250                 255     
Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys
            260                 265                 270         
Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln
        275                 280                 285             
Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile
    290                 295                 300                 
Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp
305                 310                 315                 320 
Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn
                325                 330                 335     
Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu
            340                 345                 350         
Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu
        355                 360                 365             
Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln
    370                 375                 380                 
Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu
385                 390                 395                 400 
Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro
                405                 410                 415     
Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp
            420                 425                 430         
Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser
        435                 440                 445             
Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu
    450                 455                 460                 
Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile
465                 470                 475                 480 
Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu
                485                 490                 495     
Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro
            500                 505                 510         
Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly
        515                 520                 525             
Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg
    530                 535                 540                 
Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile
545                 550                 555                 560 
Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser
                565                 570                 575     
Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys
            580                 585                 590         
Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu
        595                 600                 605             
Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe
    610                 615                 620                 
Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe
625                 630                 635                 640 
Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala
                645                 650                 655     
Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu
            660                 665                 670         
Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met
        675                 680                 685             
Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr
    690                 695                 700                 
Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala
705                 710                 715                 720 
Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln
                725                 730                 735     
Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu
            740                 745                 750         
Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln
        755                 760                 765             
Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys
    770                 775                 780                 
Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro
785                 790                 795                 800 
Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met
                805                 810                 815     
Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg
            820                 825                 830         
Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln
        835                 840                 845             
Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg
    850                 855                 860                 
Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala
865                 870                 875                 880 
Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly
                885                 890                 895     
Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu
            900                 905                 910         
Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp
        915                 920                 925             
Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg
    930                 935                 940                 
Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg
945                 950                 955                 960 
Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg
                965                 970                 975     
Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly
            980                 985                 990         
Glu Gly Glu Gly Pro Asp Gly Gly Glu Arg Arg Arg Arg His Arg His
        995                 1000                1005            
Gly Ala Pro Ala Thr Tyr Glu Gly Asp Ala Arg Arg Glu Asp Lys Glu
    1010                1015                1020                
Arg Arg His Arg Arg Arg Lys Glu Asn Gln Gly Ser Gly Val Pro Val
1025                1030                1035                1040
Ser Gly Pro Asn Leu Ser Thr Thr Arg Pro Ile Gln Gln Asp Leu Gly
                1045                1050                1055    
Arg Gln Asp Pro Pro Leu Ala Glu Asp Ile Asp Asn Met Lys Asn Asn
            1060                1065                1070        
Lys Leu Ala Thr Ala Glu Ser Ala Ala Pro His Gly Ser Leu Gly His
        1075                1080                1085            
Ala Gly Leu Pro Gln Ser Pro Ala Lys Met Gly Asn Ser Thr Asp Pro
    1090                1095                1100                
Gly Pro Met Leu Ala Ile Pro Ala Met Ala Thr Asn Pro Gln Asn Ala
1105                1110                1115                1120
Ala Ser Arg Arg Thr Pro Asn Asn Pro Gly Asn Pro Ser Asn Pro Gly
                1125                1130                1135    
Pro Pro Lys Thr Pro Glu Asn Ser Leu Ile Val Thr Asn Pro Ser Gly
            1140                1145                1150        
Thr Gln Thr Asn Ser Ala Lys Thr Ala Arg Lys Pro Asp His Thr Thr
        1155                1160                1165            
Val Asp Ile Pro Pro Ala Cys Pro Pro Pro Leu Asn His Thr Val Val
    1170                1175                1180                
Gln Val Asn Lys Asn Ala Asn Pro Asp Pro Leu Pro Lys Lys Glu Glu
1185                1190                1195                1200
Glu Lys Lys Glu Glu Glu Glu Asp Asp Arg Gly Glu Asp Gly Pro Lys
                1205                1210                1215    
Pro Met Pro Pro Tyr Ser Ser Met Phe Ile Leu Ser Thr Thr Asn Pro
            1220                1225                1230        
Leu Arg Arg Leu Cys His Tyr Ile Leu Asn Leu Arg Tyr Phe Glu Met
        1235                1240                1245            
Cys Ile Leu Met Val Ile Ala Met Ser Ser Ile Ala Leu Ala Ala Glu
    1250                1255                1260                
Asp Pro Val Gln Pro Asn Ala Pro Arg Asn Asn Val Leu Arg Tyr Phe
1265                1270                1275                1280
Asp Tyr Val Phe Thr Gly Val Phe Thr Phe Glu Met Val Ile Lys Met
                1285                1290                1295    
Ile Asp Leu Gly Leu Val Leu His Gln Gly Ala Tyr Phe Arg Asp Leu
            1300                1305                1310        
Trp Asn Ile Leu Asp Phe Ile Val Val Ser Gly Ala Leu Val Ala Phe
        1315                1320                1325            
Ala Phe Thr Gly Asn Ser Lys Gly Lys Asp Ile Asn Thr Ile Lys Ser
    1330                1335                1340                
Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg Leu
1345                1350                1355                1360
Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val Asn Ser Leu Lys Asn
                1365                1370                1375    
Val Phe Asn Ile Leu Ile Val Tyr Met Leu Phe Met Phe Ile Phe Ala
            1380                1385                1390        
Val Val Ala Val Gln Leu Phe Lys Gly Lys Phe Phe His Cys Thr Asp
        1395                1400                1405            
Glu Ser Lys Glu Phe Glu Lys Asp Cys Arg Gly Lys Tyr Leu Leu Tyr
    1410                1415                1420                
Glu Lys Asn Glu Val Lys Ala Arg Asp Arg Glu Trp Lys Lys Tyr Glu
1425                1430                1435                1440
Phe His Tyr Asp Asn Val Leu Trp Ala Leu Leu Thr Leu Phe Thr Val
                1445                1450                1455    
Ser Thr Gly Glu Gly Trp Pro Gln Val Leu Lys His Ser Val Asp Ala
            1460                1465                1470        
Thr Phe Glu Asn Gln Gly Pro Ser Pro Gly Tyr Arg Met Glu Met Ser
        1475                1480                1485            
Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro Phe Phe Phe Val Asn
    1490                1495                1500                
Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln Glu Gln Gly Asp Lys
1505                1510                1515                1520
Met Met Glu Glu Tyr Ser Leu Glu Lys Asn Glu Arg Ala Cys Ile Asp
                1525                1530                1535    
Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg His Met Pro Gln Asn Lys
            1540                1545                1550        
Gln Ser Phe Gln Tyr Arg Met Trp Gln Phe Val Val Ser Pro Pro Phe
        1555                1560                1565            
Glu Tyr Thr Ile Met Ala Met Ile Ala Leu Asn Thr Ile Val Leu Met
    1570                1575                1580                
Met Lys Phe Tyr Gly Ala Ser Val Ala Tyr Glu Asn Ala Leu Arg Val
1585                1590                1595                1600
Phe Asn Ile Val Phe Thr Ser Leu Phe Ser Leu Glu Cys Val Leu Lys
                1605                1610                1615    
Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile
            1620                1625                1630        
Phe Asp Phe Val Thr Val Leu Gly Ser Ile Thr Asp Ile Leu Val Thr
        1635                1640                1645            
Glu Phe Gly Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu Phe Arg
    1650                1655                1660                
Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Thr Ile Arg Ile
1665                1670                1675                1680
Leu Leu Trp Thr Phe Val Gln Ser Phe Lys Ala Leu Pro Tyr Val Cys
                1685                1690                1695    
Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile Gly Met Gln
            1700                1705                1710        
Val Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp Ser Asp Glu
        1715                1720                1725            
Asp Glu Phe Gln Ile Thr Glu His Asn Asn Phe Arg Thr Phe Phe Gln
    1730                1735                1740                
Ala Leu Met Leu Leu Phe Arg Ser Ala Thr Gly Glu Ala Trp His Asn
1745                1750                1755                1760
Ile Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn Ser Gly
                1765                1770                1775    
Ile Leu Thr Arg Glu Cys Gly Asn Glu Phe Ala Tyr Phe Tyr Phe Val
            1780                1785                1790        
Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu Phe Val Ala
        1795                1800                1805            
Val Ile Met Asp Asn Phe Glu Tyr Leu Thr Arg Asp Ser Ser Ile Leu
    1810                1815                1820                
Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala Glu Tyr Asp
1825                1830                1835                1840
Pro Ala Ala Trp Gly Arg Met Pro Tyr Leu Asp Met Tyr Gln Met Leu
                1845                1850                1855    
Arg His Met Ser Pro Pro Leu Gly Leu Gly Lys Lys Cys Pro Ala Arg
            1860                1865                1870        
Val Ala Tyr Lys Arg Leu Leu Arg Met Asp Leu Pro Val Ala Asp Asp
        1875                1880                1885            
Asn Thr Val His Phe Asn Ser Thr Leu Met Ala Leu Ile Arg Thr Ala
    1890                1895                1900                
Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln Gln Met Asp
1905                1910                1915                1920
Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn Leu Ser Gln
                1925                1930                1935    
Lys Thr Leu Asp Leu Leu Val Thr Pro His Lys Ser Thr Asp Leu Thr
            1940                1945                1950        
Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr Arg Gln
        1955                1960                1965            
Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln Asp Arg Thr
    1970                1975                1980                
Pro Leu Met Phe Gln Arg Met Glu Pro Pro Ser Pro Thr Gln Glu Gly
1985                1990                1995                2000
Gly Pro Gly Gln Asn Ala Leu Pro Ser Thr Gln Leu Asp Pro Gly Gly
                2005                2010                2015    
Ala Leu Met Ala His Glu Ser Gly Leu Lys Glu Ser Pro Ser Trp Val
            2020                2025                2030        
Thr Gln Arg Ala Gln Glu Met Phe Gln Lys Thr Gly Thr Trp Ser Pro
        2035                2040                2045            
Glu Gln Gly Pro Pro Thr Asp Met Pro Asn Ser Gln Pro Asn Ser Gln
    2050                2055                2060                
Ser Val Glu Met Arg Glu Met Gly Arg Asp Gly Tyr Ser Asp Ser Glu
2065                2070                2075                2080
His Tyr Leu Pro Met Glu Gly Gln Gly Arg Ala Ala Ser Met Pro Arg
                2085                2090                2095    
Leu Pro Ala Glu Asn Gln Arg Arg Arg Gly Arg Pro Arg Gly Asn Asn
            2100                2105                2110        
Leu Ser Thr Ile Ser Asp Thr Ser Pro Met Lys Arg Ser Ala Ser Val
        2115                2120                2125            
Leu Gly Pro Lys Ala Arg Arg Leu Asp Asp Tyr Ser Leu Glu Arg Val
    2130                2135                2140                
Pro Pro Glu Glu Asn Gln Arg His His Gln Arg Arg Arg Asp Arg Ser
2145                2150                2155                2160
His Arg Ala Ser Glu Arg Ser Leu Gly Arg Tyr Thr Asp Val Asp Thr
                2165                2170                2175    
Gly Leu Gly Thr Asp Leu Ser Met Thr Thr Gln Ser Gly Asp Leu Pro
            2180                2185                2190        
Ser Lys Glu Arg Asp Gln Glu Arg Gly Arg Pro Lys Asp Arg Lys His
        2195                2200                2205            
Arg Gln His His His His His His His His His His Pro Pro Pro Pro
    2210                2215                2220                
Asp Lys Asp Arg Tyr Ala Gln Glu Arg Pro Asp His Gly Arg Ala Arg
2225                2230                2235                2240
Ala Arg Asp Gln Arg Trp Ser Arg Ser Pro Ser Glu Gly Arg Glu His
                2245                2250                2255    
Met Ala His Arg Gln Gly Ser Ser Ser Val Ser Gly Ser Pro Ala Pro
            2260                2265                2270        
Ser Thr Ser Gly Thr Ser Thr Pro Arg Arg Gly Arg Arg Gln Leu Pro
        2275                2280                2285            
Gln Thr Pro Ser Thr Pro Arg Pro His Val Ser Tyr Ser Pro Val Ile
    2290                2295                2300                
Arg Lys Ala Gly Gly Ser Gly Pro Pro Gln Gln Gln Gln Gln Gln Gln
2305                2310                2315                2320
Gln Gln Gln Gln Ala Val Ala Arg Pro Gly Arg Ala Ala Thr Ser Gly
                2325                2330                2335    
Pro Arg Arg Tyr Pro Gly Pro Thr Ala Glu Pro Leu Ala Gly Asp Arg
            2340                2345                2350        
Pro Pro Thr Gly Gly His Ser Ser Gly Arg Ser Pro Arg Met Glu Arg
        2355                2360                2365            
Arg Val Pro Gly Pro Ala Arg Ser Glu Ser Pro Arg Ala Cys Arg His
    2370                2375                2380                
Gly Gly Ala Arg Trp Pro Ala Ser Gly Pro His Val Ser Glu Gly Pro
2385                2390                2395                2400
Pro Gly Pro Arg His His Gly Tyr Tyr Arg Gly Ser Asp Tyr Asp Glu
                2405                2410                2415    
Ala Asp Gly Pro Gly Ser Gly Gly Gly Glu Glu Ala Met Ala Gly Ala
            2420                2425                2430        
Tyr Asp Ala Pro Pro Pro Val Arg His Ala Ser Ser Gly Ala Thr Gly
        2435                2440                2445            
Arg Ser Pro Arg Thr Pro Arg Ala Ser Gly Pro Ala Cys Ala Ser Pro
    2450                2455                2460                
Ser Arg His Gly Arg Arg Leu Pro Asn Gly Tyr Tyr Pro Ala His Gly
2465                2470                2475                2480
Leu Ala Arg Pro Arg Gly Pro Gly Ser Arg Lys Gly Leu His Glu Pro
                2485                2490                2495    
Tyr Ser Glu Ser Asp Asp Asp Trp Cys
            2500                2505


<210> 9213
<211> 2261
<212> PRT
<213> Homo sapiens

<400> 9213
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly
            20                  25                  30          
Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr
        35                  40                  45              
Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro
    50                  55                  60                  
Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu
65                  70                  75                  80  
Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu
                85                  90                  95      
Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys
            100                 105                 110         
Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro
        115                 120                 125             
Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe
    130                 135                 140                 
Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His
145                 150                 155                 160 
Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val
                165                 170                 175     
Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg
            180                 185                 190         
Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly
        195                 200                 205             
Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile
    210                 215                 220                 
Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe
225                 230                 235                 240 
Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys
                245                 250                 255     
Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys
            260                 265                 270         
Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln
        275                 280                 285             
Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile
    290                 295                 300                 
Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp
305                 310                 315                 320 
Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn
                325                 330                 335     
Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu
            340                 345                 350         
Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu
        355                 360                 365             
Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln
    370                 375                 380                 
Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu
385                 390                 395                 400 
Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro
                405                 410                 415     
Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp
            420                 425                 430         
Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser
        435                 440                 445             
Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu
    450                 455                 460                 
Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile
465                 470                 475                 480 
Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu
                485                 490                 495     
Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro
            500                 505                 510         
Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly
        515                 520                 525             
Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg
    530                 535                 540                 
Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile
545                 550                 555                 560 
Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser
                565                 570                 575     
Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys
            580                 585                 590         
Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu
        595                 600                 605             
Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe
    610                 615                 620                 
Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe
625                 630                 635                 640 
Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala
                645                 650                 655     
Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu
            660                 665                 670         
Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met
        675                 680                 685             
Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr
    690                 695                 700                 
Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala
705                 710                 715                 720 
Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln
                725                 730                 735     
Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu
            740                 745                 750         
Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln
        755                 760                 765             
Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys
    770                 775                 780                 
Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro
785                 790                 795                 800 
Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met
                805                 810                 815     
Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg
            820                 825                 830         
Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln
        835                 840                 845             
Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg
    850                 855                 860                 
Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala
865                 870                 875                 880 
Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly
                885                 890                 895     
Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu
            900                 905                 910         
Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp
        915                 920                 925             
Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg
    930                 935                 940                 
Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg
945                 950                 955                 960 
Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg
                965                 970                 975     
Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly
            980                 985                 990         
Glu Gly Glu Gly Pro Asp Gly Gly Glu Arg Arg Arg Arg His Arg His
        995                 1000                1005            
Gly Ala Pro Ala Thr Tyr Glu Gly Asp Ala Arg Arg Glu Asp Lys Glu
    1010                1015                1020                
Arg Arg His Arg Arg Arg Lys Glu Asn Gln Gly Ser Gly Val Pro Val
1025                1030                1035                1040
Ser Gly Pro Asn Leu Ser Thr Thr Arg Pro Ile Gln Gln Asp Leu Gly
                1045                1050                1055    
Arg Gln Asp Pro Pro Leu Ala Glu Asp Ile Asp Asn Met Lys Asn Asn
            1060                1065                1070        
Lys Leu Ala Thr Ala Glu Ser Ala Ala Pro His Gly Ser Leu Gly His
        1075                1080                1085            
Ala Gly Leu Pro Gln Ser Pro Ala Lys Met Gly Asn Ser Thr Asp Pro
    1090                1095                1100                
Gly Pro Met Leu Ala Ile Pro Ala Met Ala Thr Asn Pro Gln Asn Ala
1105                1110                1115                1120
Ala Ser Arg Arg Thr Pro Asn Asn Pro Gly Asn Pro Ser Asn Pro Gly
                1125                1130                1135    
Pro Pro Lys Thr Pro Glu Asn Ser Leu Ile Val Thr Asn Pro Ser Gly
            1140                1145                1150        
Thr Gln Thr Asn Ser Ala Lys Thr Ala Arg Lys Pro Asp His Thr Thr
        1155                1160                1165            
Val Asp Ile Pro Pro Ala Cys Pro Pro Pro Leu Asn His Thr Val Val
    1170                1175                1180                
Gln Val Asn Lys Asn Ala Asn Pro Asp Pro Leu Pro Lys Lys Glu Glu
1185                1190                1195                1200
Glu Lys Lys Glu Glu Glu Glu Asp Asp Arg Gly Glu Asp Gly Pro Lys
                1205                1210                1215    
Pro Met Pro Pro Tyr Ser Ser Met Phe Ile Leu Ser Thr Thr Asn Pro
            1220                1225                1230        
Leu Arg Arg Leu Cys His Tyr Ile Leu Asn Leu Arg Tyr Phe Glu Met
        1235                1240                1245            
Cys Ile Leu Met Val Ile Ala Met Ser Ser Ile Ala Leu Ala Ala Glu
    1250                1255                1260                
Asp Pro Val Gln Pro Asn Ala Pro Arg Asn Asn Val Leu Arg Tyr Phe
1265                1270                1275                1280
Asp Tyr Val Phe Thr Gly Val Phe Thr Phe Glu Met Val Ile Lys Met
                1285                1290                1295    
Ile Asp Leu Gly Leu Val Leu His Gln Gly Ala Tyr Phe Arg Asp Leu
            1300                1305                1310        
Trp Asn Ile Leu Asp Phe Ile Val Val Ser Gly Ala Leu Val Ala Phe
        1315                1320                1325            
Ala Phe Thr Gly Asn Ser Lys Gly Lys Asp Ile Asn Thr Ile Lys Ser
    1330                1335                1340                
Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg Leu
1345                1350                1355                1360
Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val Asn Ser Leu Lys Asn
                1365                1370                1375    
Val Phe Asn Ile Leu Ile Val Tyr Met Leu Phe Met Phe Ile Phe Ala
            1380                1385                1390        
Val Val Ala Val Gln Leu Phe Lys Gly Lys Phe Phe His Cys Thr Asp
        1395                1400                1405            
Glu Ser Lys Glu Phe Glu Lys Asp Cys Arg Gly Lys Tyr Leu Leu Tyr
    1410                1415                1420                
Glu Lys Asn Glu Val Lys Ala Arg Asp Arg Glu Trp Lys Lys Tyr Glu
1425                1430                1435                1440
Phe His Tyr Asp Asn Val Leu Trp Ala Leu Leu Thr Leu Phe Thr Val
                1445                1450                1455    
Ser Thr Gly Glu Gly Trp Pro Gln Val Leu Lys His Ser Val Asp Ala
            1460                1465                1470        
Thr Phe Glu Asn Gln Gly Pro Ser Pro Gly Tyr Arg Met Glu Met Ser
        1475                1480                1485            
Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro Phe Phe Phe Val Asn
    1490                1495                1500                
Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln Glu Gln Gly Asp Lys
1505                1510                1515                1520
Met Met Glu Glu Tyr Ser Leu Glu Lys Asn Glu Arg Ala Cys Ile Asp
                1525                1530                1535    
Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg His Met Pro Gln Asn Lys
            1540                1545                1550        
Gln Ser Phe Gln Tyr Arg Met Trp Gln Phe Val Val Ser Pro Pro Phe
        1555                1560                1565            
Glu Tyr Thr Ile Met Ala Met Ile Ala Leu Asn Thr Ile Val Leu Met
    1570                1575                1580                
Met Lys Phe Tyr Gly Ala Ser Val Ala Tyr Glu Asn Ala Leu Arg Val
1585                1590                1595                1600
Phe Asn Ile Val Phe Thr Ser Leu Phe Ser Leu Glu Cys Val Leu Lys
                1605                1610                1615    
Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile
            1620                1625                1630        
Phe Asp Phe Val Thr Val Leu Gly Ser Ile Thr Asp Ile Leu Val Thr
        1635                1640                1645            
Glu Phe Gly Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu Phe Arg
    1650                1655                1660                
Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Thr Ile Arg Ile
1665                1670                1675                1680
Leu Leu Trp Thr Phe Val Gln Ser Phe Lys Ala Leu Pro Tyr Val Cys
                1685                1690                1695    
Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile Gly Met Gln
            1700                1705                1710        
Val Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp Ser Asp Glu
        1715                1720                1725            
Asp Glu Phe Gln Ile Thr Glu His Asn Asn Phe Arg Thr Phe Phe Gln
    1730                1735                1740                
Ala Leu Met Leu Leu Phe Arg Ser Ala Thr Gly Glu Ala Trp His Asn
1745                1750                1755                1760
Ile Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn Ser Gly
                1765                1770                1775    
Ile Leu Thr Arg Glu Cys Gly Asn Glu Phe Ala Tyr Phe Tyr Phe Val
            1780                1785                1790        
Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu Phe Val Ala
        1795                1800                1805            
Val Ile Met Asp Asn Phe Glu Tyr Leu Thr Arg Asp Ser Ser Ile Leu
    1810                1815                1820                
Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala Glu Tyr Asp
1825                1830                1835                1840
Pro Ala Ala Cys Gly Arg Ile His Tyr Lys Asp Met Tyr Ser Leu Leu
                1845                1850                1855    
Arg Val Ile Ser Pro Pro Leu Gly Leu Gly Lys Lys Cys Pro His Arg
            1860                1865                1870        
Val Ala Cys Lys Arg Leu Leu Arg Met Asp Leu Pro Val Ala Asp Asp
        1875                1880                1885            
Asn Thr Val His Phe Asn Ser Thr Leu Met Ala Leu Ile Arg Thr Ala
    1890                1895                1900                
Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln Gln Met Asp
1905                1910                1915                1920
Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn Leu Ser Gln
                1925                1930                1935    
Lys Thr Leu Asp Leu Leu Val Thr Pro His Lys Ser Thr Asp Leu Thr
            1940                1945                1950        
Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr Arg Gln
        1955                1960                1965            
Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln Asp Arg Thr
    1970                1975                1980                
Pro Leu Met Phe Gln Arg Met Glu Pro Pro Ser Pro Thr Gln Glu Gly
1985                1990                1995                2000
Gly Pro Gly Gln Asn Ala Leu Pro Ser Thr Gln Leu Asp Pro Gly Gly
                2005                2010                2015    
Ala Leu Met Ala His Glu Ser Gly Leu Lys Glu Ser Pro Ser Trp Val
            2020                2025                2030        
Thr Gln Arg Ala Gln Glu Met Phe Gln Lys Thr Gly Thr Trp Ser Pro
        2035                2040                2045            
Glu Gln Gly Pro Pro Thr Asp Met Pro Asn Ser Gln Pro Asn Ser Gln
    2050                2055                2060                
Ser Val Glu Met Arg Glu Met Gly Arg Asp Gly Tyr Ser Asp Ser Glu
2065                2070                2075                2080
His Tyr Leu Pro Met Glu Gly Gln Gly Arg Ala Ala Ser Met Pro Arg
                2085                2090                2095    
Leu Pro Ala Glu Asn Gln Arg Arg Arg Gly Arg Pro Arg Gly Asn Asn
            2100                2105                2110        
Leu Ser Thr Ile Ser Asp Thr Ser Pro Met Lys Arg Ser Ala Ser Val
        2115                2120                2125            
Leu Gly Pro Lys Ala Arg Arg Leu Asp Asp Tyr Ser Leu Glu Arg Val
    2130                2135                2140                
Pro Pro Glu Glu Asn Gln Arg His His Gln Arg Arg Arg Asp Arg Ser
2145                2150                2155                2160
His Arg Ala Ser Glu Arg Ser Leu Gly Arg Tyr Thr Asp Val Asp Thr
                2165                2170                2175    
Gly Leu Gly Thr Asp Leu Ser Met Thr Thr Gln Ser Gly Asp Leu Pro
            2180                2185                2190        
Ser Lys Glu Arg Asp Gln Glu Arg Gly Arg Pro Lys Asp Arg Lys His
        2195                2200                2205            
Arg Gln His His His His His His His His His His Pro Pro Pro Pro
    2210                2215                2220                
Asp Lys Asp Arg Tyr Ala Gln Glu Arg Pro Asp His Gly Arg Ala Arg
2225                2230                2235                2240
Ala Arg Asp Gln Arg Trp Ser Arg Ser Pro Ser Glu Gly Arg Glu His
                2245                2250                2255    
Met Ala His Arg Gln
            2260    


<210> 9214
<211> 2505
<212> PRT
<213> Homo sapiens

<400> 9214
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly
            20                  25                  30          
Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr
        35                  40                  45              
Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro
    50                  55                  60                  
Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu
65                  70                  75                  80  
Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu
                85                  90                  95      
Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys
            100                 105                 110         
Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro
        115                 120                 125             
Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe
    130                 135                 140                 
Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His
145                 150                 155                 160 
Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val
                165                 170                 175     
Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg
            180                 185                 190         
Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly
        195                 200                 205             
Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile
    210                 215                 220                 
Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe
225                 230                 235                 240 
Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys
                245                 250                 255     
Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys
            260                 265                 270         
Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln
        275                 280                 285             
Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile
    290                 295                 300                 
Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp
305                 310                 315                 320 
Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn
                325                 330                 335     
Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu
            340                 345                 350         
Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu
        355                 360                 365             
Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln
    370                 375                 380                 
Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu
385                 390                 395                 400 
Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro
                405                 410                 415     
Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp
            420                 425                 430         
Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser
        435                 440                 445             
Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu
    450                 455                 460                 
Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile
465                 470                 475                 480 
Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu
                485                 490                 495     
Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro
            500                 505                 510         
Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly
        515                 520                 525             
Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg
    530                 535                 540                 
Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile
545                 550                 555                 560 
Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser
                565                 570                 575     
Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys
            580                 585                 590         
Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu
        595                 600                 605             
Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe
    610                 615                 620                 
Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe
625                 630                 635                 640 
Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala
                645                 650                 655     
Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu
            660                 665                 670         
Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met
        675                 680                 685             
Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr
    690                 695                 700                 
Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala
705                 710                 715                 720 
Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln
                725                 730                 735     
Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu
            740                 745                 750         
Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln
        755                 760                 765             
Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys
    770                 775                 780                 
Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro
785                 790                 795                 800 
Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met
                805                 810                 815     
Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg
            820                 825                 830         
Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln
        835                 840                 845             
Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg
    850                 855                 860                 
Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala
865                 870                 875                 880 
Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly
                885                 890                 895     
Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu
            900                 905                 910         
Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp
        915                 920                 925             
Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg
    930                 935                 940                 
Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg
945                 950                 955                 960 
Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg
                965                 970                 975     
Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly
            980                 985                 990         
Glu Gly Glu Gly Pro Asp Gly Gly Glu Arg Arg Arg Arg His Arg His
        995                 1000                1005            
Gly Ala Pro Ala Thr Tyr Glu Gly Asp Ala Arg Arg Glu Asp Lys Glu
    1010                1015                1020                
Arg Arg His Arg Arg Arg Lys Glu Asn Gln Gly Ser Gly Val Pro Val
1025                1030                1035                1040
Ser Gly Pro Asn Leu Ser Thr Thr Arg Pro Ile Gln Gln Asp Leu Gly
                1045                1050                1055    
Arg Gln Asp Pro Pro Leu Ala Glu Asp Ile Asp Asn Met Lys Asn Asn
            1060                1065                1070        
Lys Leu Ala Thr Ala Glu Ser Ala Ala Pro His Gly Ser Leu Gly His
        1075                1080                1085            
Ala Gly Leu Pro Gln Ser Pro Ala Lys Met Gly Asn Ser Thr Asp Pro
    1090                1095                1100                
Gly Pro Met Leu Ala Ile Pro Ala Met Ala Thr Asn Pro Gln Asn Ala
1105                1110                1115                1120
Ala Ser Arg Arg Thr Pro Asn Asn Pro Gly Asn Pro Ser Asn Pro Gly
                1125                1130                1135    
Pro Pro Lys Thr Pro Glu Asn Ser Leu Ile Val Thr Asn Pro Ser Gly
            1140                1145                1150        
Thr Gln Thr Asn Ser Ala Lys Thr Ala Arg Lys Pro Asp His Thr Thr
        1155                1160                1165            
Val Asp Ile Pro Pro Ala Cys Pro Pro Pro Leu Asn His Thr Val Val
    1170                1175                1180                
Gln Val Asn Lys Asn Ala Asn Pro Asp Pro Leu Pro Lys Lys Glu Glu
1185                1190                1195                1200
Glu Lys Lys Glu Glu Glu Glu Asp Asp Arg Gly Glu Asp Gly Pro Lys
                1205                1210                1215    
Pro Met Pro Pro Tyr Ser Ser Met Phe Ile Leu Ser Thr Thr Asn Pro
            1220                1225                1230        
Leu Arg Arg Leu Cys His Tyr Ile Leu Asn Leu Arg Tyr Phe Glu Met
        1235                1240                1245            
Cys Ile Leu Met Val Ile Ala Met Ser Ser Ile Ala Leu Ala Ala Glu
    1250                1255                1260                
Asp Pro Val Gln Pro Asn Ala Pro Arg Asn Asn Val Leu Arg Tyr Phe
1265                1270                1275                1280
Asp Tyr Val Phe Thr Gly Val Phe Thr Phe Glu Met Val Ile Lys Met
                1285                1290                1295    
Ile Asp Leu Gly Leu Val Leu His Gln Gly Ala Tyr Phe Arg Asp Leu
            1300                1305                1310        
Trp Asn Ile Leu Asp Phe Ile Val Val Ser Gly Ala Leu Val Ala Phe
        1315                1320                1325            
Ala Phe Thr Gly Asn Ser Lys Gly Lys Asp Ile Asn Thr Ile Lys Ser
    1330                1335                1340                
Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg Leu
1345                1350                1355                1360
Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val Asn Ser Leu Lys Asn
                1365                1370                1375    
Val Phe Asn Ile Leu Ile Val Tyr Met Leu Phe Met Phe Ile Phe Ala
            1380                1385                1390        
Val Val Ala Val Gln Leu Phe Lys Gly Lys Phe Phe His Cys Thr Asp
        1395                1400                1405            
Glu Ser Lys Glu Phe Glu Lys Asp Cys Arg Gly Lys Tyr Leu Leu Tyr
    1410                1415                1420                
Glu Lys Asn Glu Val Lys Ala Arg Asp Arg Glu Trp Lys Lys Tyr Glu
1425                1430                1435                1440
Phe His Tyr Asp Asn Val Leu Trp Ala Leu Leu Thr Leu Phe Thr Val
                1445                1450                1455    
Ser Thr Gly Glu Gly Trp Pro Gln Val Leu Lys His Ser Val Asp Ala
            1460                1465                1470        
Thr Phe Glu Asn Gln Gly Pro Ser Pro Gly Tyr Arg Met Glu Met Ser
        1475                1480                1485            
Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro Phe Phe Phe Val Asn
    1490                1495                1500                
Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln Glu Gln Gly Asp Lys
1505                1510                1515                1520
Met Met Glu Glu Tyr Ser Leu Glu Lys Asn Glu Arg Ala Cys Ile Asp
                1525                1530                1535    
Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg His Met Pro Gln Asn Lys
            1540                1545                1550        
Gln Ser Phe Gln Tyr Arg Met Trp Gln Phe Val Val Ser Pro Pro Phe
        1555                1560                1565            
Glu Tyr Thr Ile Met Ala Met Ile Ala Leu Asn Thr Ile Val Leu Met
    1570                1575                1580                
Met Lys Phe Tyr Gly Ala Ser Val Ala Tyr Glu Asn Ala Leu Arg Val
1585                1590                1595                1600
Phe Asn Ile Val Phe Thr Ser Leu Phe Ser Leu Glu Cys Val Leu Lys
                1605                1610                1615    
Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile
            1620                1625                1630        
Phe Asp Phe Val Thr Val Leu Gly Ser Ile Thr Asp Ile Leu Val Thr
        1635                1640                1645            
Glu Phe Gly Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu Phe Arg
    1650                1655                1660                
Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Thr Ile Arg Ile
1665                1670                1675                1680
Leu Leu Trp Thr Phe Val Gln Ser Phe Lys Ala Leu Pro Tyr Val Cys
                1685                1690                1695    
Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile Gly Met Gln
            1700                1705                1710        
Val Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp Ser Asp Glu
        1715                1720                1725            
Asp Glu Phe Gln Ile Thr Glu His Asn Asn Phe Arg Thr Phe Phe Gln
    1730                1735                1740                
Ala Leu Met Leu Leu Phe Arg Ser Ala Thr Gly Glu Ala Trp His Asn
1745                1750                1755                1760
Ile Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn Ser Gly
                1765                1770                1775    
Ile Leu Thr Arg Glu Cys Gly Asn Glu Phe Ala Tyr Phe Tyr Phe Val
            1780                1785                1790        
Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu Phe Val Ala
        1795                1800                1805            
Val Ile Met Asp Asn Phe Glu Tyr Leu Thr Arg Asp Ser Ser Ile Leu
    1810                1815                1820                
Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala Glu Tyr Asp
1825                1830                1835                1840
Pro Ala Ala Cys Gly Arg Ile His Tyr Lys Asp Met Tyr Ser Leu Leu
                1845                1850                1855    
Arg Val Ile Ser Pro Pro Leu Gly Leu Gly Lys Lys Cys Pro His Arg
            1860                1865                1870        
Val Ala Cys Lys Arg Leu Leu Arg Met Asp Leu Pro Val Ala Asp Asp
        1875                1880                1885            
Asn Thr Val His Phe Asn Ser Thr Leu Met Ala Leu Ile Arg Thr Ala
    1890                1895                1900                
Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln Gln Met Asp
1905                1910                1915                1920
Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn Leu Ser Gln
                1925                1930                1935    
Lys Thr Leu Asp Leu Leu Val Thr Pro His Lys Ser Thr Asp Leu Thr
            1940                1945                1950        
Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr Arg Gln
        1955                1960                1965            
Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln Asp Arg Thr
    1970                1975                1980                
Pro Leu Met Phe Gln Arg Met Glu Pro Pro Ser Pro Thr Gln Glu Gly
1985                1990                1995                2000
Gly Pro Gly Gln Asn Ala Leu Pro Ser Thr Gln Leu Asp Pro Gly Gly
                2005                2010                2015    
Ala Leu Met Ala His Glu Ser Gly Leu Lys Glu Ser Pro Ser Trp Val
            2020                2025                2030        
Thr Gln Arg Ala Gln Glu Met Phe Gln Lys Thr Gly Thr Trp Ser Pro
        2035                2040                2045            
Glu Gln Gly Pro Pro Thr Asp Met Pro Asn Ser Gln Pro Asn Ser Gln
    2050                2055                2060                
Ser Val Glu Met Arg Glu Met Gly Arg Asp Gly Tyr Ser Asp Ser Glu
2065                2070                2075                2080
His Tyr Leu Pro Met Glu Gly Gln Gly Arg Ala Ala Ser Met Pro Arg
                2085                2090                2095    
Leu Pro Ala Glu Asn Gln Arg Arg Arg Gly Arg Pro Arg Gly Asn Asn
            2100                2105                2110        
Leu Ser Thr Ile Ser Asp Thr Ser Pro Met Lys Arg Ser Ala Ser Val
        2115                2120                2125            
Leu Gly Pro Lys Ala Arg Arg Leu Asp Asp Tyr Ser Leu Glu Arg Val
    2130                2135                2140                
Pro Pro Glu Glu Asn Gln Arg His His Gln Arg Arg Arg Asp Arg Ser
2145                2150                2155                2160
His Arg Ala Ser Glu Arg Ser Leu Gly Arg Tyr Thr Asp Val Asp Thr
                2165                2170                2175    
Gly Leu Gly Thr Asp Leu Ser Met Thr Thr Gln Ser Gly Asp Leu Pro
            2180                2185                2190        
Ser Lys Glu Arg Asp Gln Glu Arg Gly Arg Pro Lys Asp Arg Lys His
        2195                2200                2205            
Arg Gln His His His His His His His His His His Pro Pro Pro Pro
    2210                2215                2220                
Asp Lys Asp Arg Tyr Ala Gln Glu Arg Pro Asp His Gly Arg Ala Arg
2225                2230                2235                2240
Ala Arg Asp Gln Arg Trp Ser Arg Ser Pro Ser Glu Gly Arg Glu His
                2245                2250                2255    
Met Ala His Arg Gln Gly Ser Ser Ser Val Ser Gly Ser Pro Ala Pro
            2260                2265                2270        
Ser Thr Ser Gly Thr Ser Thr Pro Arg Arg Gly Arg Arg Gln Leu Pro
        2275                2280                2285            
Gln Thr Pro Ser Thr Pro Arg Pro His Val Ser Tyr Ser Pro Val Ile
    2290                2295                2300                
Arg Lys Ala Gly Gly Ser Gly Pro Pro Gln Gln Gln Gln Gln Gln Gln
2305                2310                2315                2320
Gln Gln Gln Gln Ala Val Ala Arg Pro Gly Arg Ala Ala Thr Ser Gly
                2325                2330                2335    
Pro Arg Arg Tyr Pro Gly Pro Thr Ala Glu Pro Leu Ala Gly Asp Arg
            2340                2345                2350        
Pro Pro Thr Gly Gly His Ser Ser Gly Arg Ser Pro Arg Met Glu Arg
        2355                2360                2365            
Arg Val Pro Gly Pro Ala Arg Ser Glu Ser Pro Arg Ala Cys Arg His
    2370                2375                2380                
Gly Gly Ala Arg Trp Pro Ala Ser Gly Pro His Val Ser Glu Gly Pro
2385                2390                2395                2400
Pro Gly Pro Arg His His Gly Tyr Tyr Arg Gly Ser Asp Tyr Asp Glu
                2405                2410                2415    
Ala Asp Gly Pro Gly Ser Gly Gly Gly Glu Glu Ala Met Ala Gly Ala
            2420                2425                2430        
Tyr Asp Ala Pro Pro Pro Val Arg His Ala Ser Ser Gly Ala Thr Gly
        2435                2440                2445            
Arg Ser Pro Arg Thr Pro Arg Ala Ser Gly Pro Ala Cys Ala Ser Pro
    2450                2455                2460                
Ser Arg His Gly Arg Arg Leu Pro Asn Gly Tyr Tyr Pro Ala His Gly
2465                2470                2475                2480
Leu Ala Arg Pro Arg Gly Pro Gly Ser Arg Lys Gly Leu His Glu Pro
                2485                2490                2495    
Tyr Ser Glu Ser Asp Asp Asp Trp Cys
            2500                2505


<210> 9215
<211> 2507
<212> PRT
<213> Homo sapiens

<400> 9215
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly
            20                  25                  30          
Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr
        35                  40                  45              
Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro
    50                  55                  60                  
Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu
65                  70                  75                  80  
Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu
                85                  90                  95      
Trp Pro Ser Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn
            100                 105                 110         
Cys Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr
        115                 120                 125             
Pro Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile
    130                 135                 140                 
Phe Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe
145                 150                 155                 160 
His Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val
                165                 170                 175     
Val Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu
            180                 185                 190         
Arg Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser
        195                 200                 205             
Gly Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met
    210                 215                 220                 
Ile Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile
225                 230                 235                 240 
Phe Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr
                245                 250                 255     
Cys Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro
            260                 265                 270         
Cys Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys
        275                 280                 285             
Gln Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn
    290                 295                 300                 
Ile Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly
305                 310                 315                 320 
Trp Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp
                325                 330                 335     
Asn Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met
            340                 345                 350         
Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg
        355                 360                 365             
Glu Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln
    370                 375                 380                 
Gln Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala
385                 390                 395                 400 
Glu Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His
                405                 410                 415     
Pro Phe Asp Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp
            420                 425                 430         
Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser
        435                 440                 445             
Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu
    450                 455                 460                 
Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile
465                 470                 475                 480 
Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu
                485                 490                 495     
Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro
            500                 505                 510         
Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly
        515                 520                 525             
Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg
    530                 535                 540                 
Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile
545                 550                 555                 560 
Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser
                565                 570                 575     
Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys
            580                 585                 590         
Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu
        595                 600                 605             
Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe
    610                 615                 620                 
Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe
625                 630                 635                 640 
Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala
                645                 650                 655     
Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu
            660                 665                 670         
Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met
        675                 680                 685             
Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr
    690                 695                 700                 
Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala
705                 710                 715                 720 
Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln
                725                 730                 735     
Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu
            740                 745                 750         
Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln
        755                 760                 765             
Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys
    770                 775                 780                 
Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro
785                 790                 795                 800 
Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met
                805                 810                 815     
Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg
            820                 825                 830         
Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln
        835                 840                 845             
Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg
    850                 855                 860                 
Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala
865                 870                 875                 880 
Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly
                885                 890                 895     
Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu
            900                 905                 910         
Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp
        915                 920                 925             
Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg
    930                 935                 940                 
Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg
945                 950                 955                 960 
Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg
                965                 970                 975     
Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly
            980                 985                 990         
Glu Gly Glu Gly Pro Asp Gly Gly Glu Arg Arg Arg Arg His Arg His
        995                 1000                1005            
Gly Ala Pro Ala Thr Tyr Glu Gly Asp Ala Arg Arg Glu Asp Lys Glu
    1010                1015                1020                
Arg Arg His Arg Arg Arg Lys Glu Asn Gln Gly Ser Gly Val Pro Val
1025                1030                1035                1040
Ser Gly Pro Asn Leu Ser Thr Thr Arg Pro Ile Gln Gln Asp Leu Gly
                1045                1050                1055    
Arg Gln Asp Pro Pro Leu Ala Glu Asp Ile Asp Asn Met Lys Asn Asn
            1060                1065                1070        
Lys Leu Ala Thr Ala Glu Ser Ala Ala Pro His Gly Ser Leu Gly His
        1075                1080                1085            
Ala Gly Leu Pro Gln Ser Pro Ala Lys Met Gly Asn Ser Thr Asp Pro
    1090                1095                1100                
Gly Pro Met Leu Ala Ile Pro Ala Met Ala Thr Asn Pro Gln Asn Ala
1105                1110                1115                1120
Ala Ser Arg Arg Thr Pro Asn Asn Pro Gly Asn Pro Ser Asn Pro Gly
                1125                1130                1135    
Pro Pro Lys Thr Pro Glu Asn Ser Leu Ile Val Thr Asn Pro Ser Gly
            1140                1145                1150        
Thr Gln Thr Asn Ser Ala Lys Thr Ala Arg Lys Pro Asp His Thr Thr
        1155                1160                1165            
Val Asp Ile Pro Pro Ala Cys Pro Pro Pro Leu Asn His Thr Val Val
    1170                1175                1180                
Gln Val Asn Lys Asn Ala Asn Pro Asp Pro Leu Pro Lys Lys Glu Glu
1185                1190                1195                1200
Glu Lys Lys Glu Glu Glu Glu Asp Asp Arg Gly Glu Asp Gly Pro Lys
                1205                1210                1215    
Pro Met Pro Pro Tyr Ser Ser Met Phe Ile Leu Ser Thr Thr Asn Pro
            1220                1225                1230        
Leu Arg Arg Leu Cys His Tyr Ile Leu Asn Leu Arg Tyr Phe Glu Met
        1235                1240                1245            
Cys Ile Leu Met Val Ile Ala Met Ser Ser Ile Ala Leu Ala Ala Glu
    1250                1255                1260                
Asp Pro Val Gln Pro Asn Ala Pro Arg Asn Asn Val Leu Arg Tyr Phe
1265                1270                1275                1280
Asp Tyr Val Phe Thr Gly Val Phe Thr Phe Glu Met Val Ile Lys Met
                1285                1290                1295    
Ile Asp Leu Gly Leu Val Leu His Gln Gly Ala Tyr Phe Arg Asp Leu
            1300                1305                1310        
Trp Asn Ile Leu Asp Phe Ile Val Val Ser Gly Ala Leu Val Ala Phe
        1315                1320                1325            
Ala Phe Thr Gly Asn Ser Lys Gly Lys Asp Ile Asn Thr Ile Lys Ser
    1330                1335                1340                
Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg Leu
1345                1350                1355                1360
Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val Asn Ser Leu Lys Asn
                1365                1370                1375    
Val Phe Asn Ile Leu Ile Val Tyr Met Leu Phe Met Phe Ile Phe Ala
            1380                1385                1390        
Val Val Ala Val Gln Leu Phe Lys Gly Lys Phe Phe His Cys Thr Asp
        1395                1400                1405            
Glu Ser Lys Glu Phe Glu Lys Asp Cys Arg Gly Lys Tyr Leu Leu Tyr
    1410                1415                1420                
Glu Lys Asn Glu Val Lys Ala Arg Asp Arg Glu Trp Lys Lys Tyr Glu
1425                1430                1435                1440
Phe His Tyr Asp Asn Val Leu Trp Ala Leu Leu Thr Leu Phe Thr Val
                1445                1450                1455    
Ser Thr Gly Glu Gly Trp Pro Gln Val Leu Lys His Ser Val Asp Ala
            1460                1465                1470        
Thr Phe Glu Asn Gln Gly Pro Ser Pro Gly Tyr Arg Met Glu Met Ser
        1475                1480                1485            
Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro Phe Phe Phe Val Asn
    1490                1495                1500                
Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln Glu Gln Gly Asp Lys
1505                1510                1515                1520
Met Met Glu Glu Tyr Ser Leu Glu Lys Asn Glu Arg Ala Cys Ile Asp
                1525                1530                1535    
Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg His Met Pro Gln Asn Lys
            1540                1545                1550        
Gln Ser Phe Gln Tyr Arg Met Trp Gln Phe Val Val Ser Pro Pro Phe
        1555                1560                1565            
Glu Tyr Thr Ile Met Ala Met Ile Ala Leu Asn Thr Ile Val Leu Met
    1570                1575                1580                
Met Lys Phe Tyr Gly Ala Ser Val Ala Tyr Glu Asn Ala Leu Arg Val
1585                1590                1595                1600
Phe Asn Ile Val Phe Thr Ser Leu Phe Ser Leu Glu Cys Val Leu Lys
                1605                1610                1615    
Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile
            1620                1625                1630        
Phe Asp Phe Val Thr Val Leu Gly Ser Ile Thr Asp Ile Leu Val Thr
        1635                1640                1645            
Glu Phe Gly Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu Phe Arg
    1650                1655                1660                
Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Thr Ile Arg Ile
1665                1670                1675                1680
Leu Leu Trp Thr Phe Val Gln Ser Phe Lys Ala Leu Pro Tyr Val Cys
                1685                1690                1695    
Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile Gly Met Gln
            1700                1705                1710        
Val Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp Ser Asp Glu
        1715                1720                1725            
Asp Glu Phe Gln Ile Thr Glu His Asn Asn Phe Arg Thr Phe Phe Gln
    1730                1735                1740                
Ala Leu Met Leu Leu Phe Arg Ser Ala Thr Gly Glu Ala Trp His Asn
1745                1750                1755                1760
Ile Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn Ser Gly
                1765                1770                1775    
Ile Leu Thr Arg Glu Cys Gly Asn Glu Phe Ala Tyr Phe Tyr Phe Val
            1780                1785                1790        
Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu Phe Val Ala
        1795                1800                1805            
Val Ile Met Asp Asn Phe Glu Tyr Leu Thr Arg Asp Ser Ser Ile Leu
    1810                1815                1820                
Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala Glu Tyr Asp
1825                1830                1835                1840
Pro Ala Ala Trp Gly Arg Met Pro Tyr Leu Asp Met Tyr Gln Met Leu
                1845                1850                1855    
Arg His Met Ser Pro Pro Leu Gly Leu Gly Lys Lys Cys Pro Ala Arg
            1860                1865                1870        
Val Ala Tyr Lys Arg Leu Leu Arg Met Asp Leu Pro Val Ala Asp Asp
        1875                1880                1885            
Asn Thr Val His Phe Asn Ser Thr Leu Met Ala Leu Ile Arg Thr Ala
    1890                1895                1900                
Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln Gln Met Asp
1905                1910                1915                1920
Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn Leu Ser Gln
                1925                1930                1935    
Lys Thr Leu Asp Leu Leu Val Thr Pro His Lys Ser Thr Asp Leu Thr
            1940                1945                1950        
Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr Arg Gln
        1955                1960                1965            
Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln Asp Arg Thr
    1970                1975                1980                
Pro Leu Met Phe Gln Arg Met Glu Pro Pro Ser Pro Thr Gln Glu Gly
1985                1990                1995                2000
Gly Pro Gly Gln Asn Ala Leu Pro Ser Thr Gln Leu Asp Pro Gly Gly
                2005                2010                2015    
Ala Leu Met Ala His Glu Ser Gly Leu Lys Glu Ser Pro Ser Trp Val
            2020                2025                2030        
Thr Gln Arg Ala Gln Glu Met Phe Gln Lys Thr Gly Thr Trp Ser Pro
        2035                2040                2045            
Glu Gln Gly Pro Pro Thr Asp Met Pro Asn Ser Gln Pro Asn Ser Gln
    2050                2055                2060                
Ser Val Glu Met Arg Glu Met Gly Arg Asp Gly Tyr Ser Asp Ser Glu
2065                2070                2075                2080
His Tyr Leu Pro Met Glu Gly Gln Gly Arg Ala Ala Ser Met Pro Arg
                2085                2090                2095    
Leu Pro Ala Glu Asn Gln Arg Arg Arg Gly Arg Pro Arg Gly Asn Asn
            2100                2105                2110        
Leu Ser Thr Ile Ser Asp Thr Ser Pro Met Lys Arg Ser Ala Ser Val
        2115                2120                2125            
Leu Gly Pro Lys Ala Arg Arg Leu Asp Asp Tyr Ser Leu Glu Arg Val
    2130                2135                2140                
Pro Pro Glu Glu Asn Gln Arg His His Gln Arg Arg Arg Asp Arg Ser
2145                2150                2155                2160
His Arg Ala Ser Glu Arg Ser Leu Gly Arg Tyr Thr Asp Val Asp Thr
                2165                2170                2175    
Gly Leu Gly Thr Asp Leu Ser Met Thr Thr Gln Ser Gly Asp Leu Pro
            2180                2185                2190        
Ser Lys Glu Arg Asp Gln Glu Arg Gly Arg Pro Lys Asp Arg Lys His
        2195                2200                2205            
Arg Gln His His His His His His His His His His Pro Pro Pro Pro
    2210                2215                2220                
Asp Lys Asp Arg Tyr Ala Gln Glu Arg Pro Asp His Gly Arg Ala Arg
2225                2230                2235                2240
Ala Arg Asp Gln Arg Trp Ser Arg Ser Pro Ser Glu Gly Arg Glu His
                2245                2250                2255    
Met Ala His Arg Gln Gly Ser Ser Ser Val Ser Gly Ser Pro Ala Pro
            2260                2265                2270        
Ser Thr Ser Gly Thr Ser Thr Pro Arg Arg Gly Arg Arg Gln Leu Pro
        2275                2280                2285            
Gln Thr Pro Ser Thr Pro Arg Pro His Val Ser Tyr Ser Pro Val Ile
    2290                2295                2300                
Arg Lys Ala Gly Gly Ser Gly Pro Pro Gln Gln Gln Gln Gln Gln Gln
2305                2310                2315                2320
Gln Gln Gln Gln Gln Gln Ala Val Ala Arg Pro Gly Arg Ala Ala Thr
                2325                2330                2335    
Ser Gly Pro Arg Arg Tyr Pro Gly Pro Thr Ala Glu Pro Leu Ala Gly
            2340                2345                2350        
Asp Arg Pro Pro Thr Gly Gly His Ser Ser Gly Arg Ser Pro Arg Met
        2355                2360                2365            
Glu Arg Arg Val Pro Gly Pro Ala Arg Ser Glu Ser Pro Arg Ala Cys
    2370                2375                2380                
Arg His Gly Gly Ala Arg Trp Pro Ala Ser Gly Pro His Val Ser Glu
2385                2390                2395                2400
Gly Pro Pro Gly Pro Arg His His Gly Tyr Tyr Arg Gly Ser Asp Tyr
                2405                2410                2415    
Asp Glu Ala Asp Gly Pro Gly Ser Gly Gly Gly Glu Glu Ala Met Ala
            2420                2425                2430        
Gly Ala Tyr Asp Ala Pro Pro Pro Val Arg His Ala Ser Ser Gly Ala
        2435                2440                2445            
Thr Gly Arg Ser Pro Arg Thr Pro Arg Ala Ser Gly Pro Ala Cys Ala
    2450                2455                2460                
Ser Pro Ser Arg His Gly Arg Arg Leu Pro Asn Gly Tyr Tyr Pro Ala
2465                2470                2475                2480
His Gly Leu Ala Arg Pro Arg Gly Pro Gly Ser Arg Lys Gly Leu His
                2485                2490                2495    
Glu Pro Tyr Ser Glu Ser Asp Asp Asp Trp Cys
            2500                2505        


<210> 9216
<211> 1951
<212> PRT
<213> Homo sapiens

<400> 9216
Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu
 1               5                  10                  15      
Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu
            20                  25                  30          
Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys
        35                  40                  45              
Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile
    50                  55                  60                  
Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu
65                  70                  75                  80  
Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly
                85                  90                  95      
Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr
            100                 105                 110         
Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser
        115                 120                 125             
Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe
    130                 135                 140                 
Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
145                 150                 155                 160 
Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg
                165                 170                 175     
Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp
            180                 185                 190         
Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser
        195                 200                 205             
Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu
    210                 215                 220                 
Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu
225                 230                 235                 240 
Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe
                245                 250                 255     
Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
            260                 265                 270         
Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu
        275                 280                 285             
Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr
    290                 295                 300                 
Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly
305                 310                 315                 320 
Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu
                325                 330                 335     
Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys
            340                 345                 350         
Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr
        355                 360                 365             
Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr
    370                 375                 380                 
Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr
385                 390                 395                 400 
Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val
                405                 410                 415     
Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln
            420                 425                 430         
Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met
        435                 440                 445             
Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala
    450                 455                 460                 
Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu
465                 470                 475                 480 
Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala
                485                 490                 495     
Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu
            500                 505                 510         
Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser
        515                 520                 525             
Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn
    530                 535                 540                 
Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu
545                 550                 555                 560 
Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser
                565                 570                 575     
Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp
            580                 585                 590         
Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg
        595                 600                 605             
Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn
    610                 615                 620                 
Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser Tyr
625                 630                 635                 640 
Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg Ala
                645                 650                 655     
Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu
            660                 665                 670         
Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe
        675                 680                 685             
Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu Val
    690                 695                 700                 
Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys
705                 710                 715                 720 
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr
                725                 730                 735     
Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly
            740                 745                 750         
Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro Tyr
        755                 760                 765             
Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser
    770                 775                 780                 
Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val
785                 790                 795                 800 
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp
                805                 810                 815     
Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala
            820                 825                 830         
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala
        835                 840                 845             
Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys
    850                 855                 860                 
Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe
865                 870                 875                 880 
Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile
                885                 890                 895     
Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu
            900                 905                 910         
Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu Asn
        915                 920                 925             
Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala
    930                 935                 940                 
Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly
945                 950                 955                 960 
Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu Cys
                965                 970                 975     
Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His Glu
            980                 985                 990         
Gly Asn Lys Ile Asp Ser Cys Met Ser Asn Asn Thr Gly Ile Glu Ile
        995                 1000                1005            
Ser Lys Glu Leu Asn Tyr Leu Arg Asp Gly Asn Gly Thr Thr Ser Gly
    1010                1015                1020                
Val Gly Thr Gly Ser Ser Val Glu Lys Tyr Val Ile Asp Glu Asn Asp
1025                1030                1035                1040
Tyr Met Ser Phe Ile Asn Asn Pro Ser Leu Thr Val Thr Val Pro Ile
                1045                1050                1055    
Ala Val Gly Glu Ser Asp Phe Glu Asn Leu Asn Thr Glu Glu Phe Ser
            1060                1065                1070        
Ser Glu Ser Glu Leu Glu Glu Ser Lys Glu Lys Leu Asn Ala Thr Ser
        1075                1080                1085            
Ser Ser Glu Gly Ser Thr Val Asp Val Val Leu Pro Arg Glu Gly Glu
    1090                1095                1100                
Gln Ala Glu Thr Glu Pro Glu Glu Asp Leu Lys Pro Glu Ala Cys Phe
1105                1110                1115                1120
Thr Glu Gly Cys Ile Lys Lys Phe Pro Phe Cys Gln Val Ser Thr Glu
                1125                1130                1135    
Glu Gly Lys Gly Lys Ile Trp Trp Asn Leu Arg Lys Thr Cys Tyr Ser
            1140                1145                1150        
Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile Leu
        1155                1160                1165            
Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Gln Arg
    1170                1175                1180                
Lys Thr Ile Lys Thr Met Leu Glu Tyr Ala Asp Lys Val Phe Thr Tyr
1185                1190                1195                1200
Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Gln
                1205                1210                1215    
Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asp
            1220                1225                1230        
Val Ser Leu Val Ser Leu Val Ala Asn Ala Leu Gly Tyr Ser Glu Leu
        1235                1240                1245            
Gly Ala Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg
    1250                1255                1260                
Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Val
1265                1270                1275                1280
Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe
                1285                1290                1295    
Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe
            1300                1305                1310        
Tyr His Cys Val Asn Met Thr Thr Gly Asn Met Phe Asp Ile Ser Asp
        1315                1320                1325            
Val Asn Asn Leu Ser Asp Cys Gln Ala Leu Gly Lys Gln Ala Arg Trp
    1330                1335                1340                
Lys Asn Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly Tyr Leu Ala
1345                1350                1355                1360
Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr Ala
                1365                1370                1375    
Ala Val Asp Ser Arg Asp Val Lys Leu Gln Pro Val Tyr Glu Glu Asn
            1380                1385                1390        
Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser Phe
        1395                1400                1405            
Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe Asn Gln
    1410                1415                1420                
Gln Lys Lys Lys Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln
1425                1430                1435                1440
Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln
                1445                1450                1455    
Lys Pro Ile Pro Arg Pro Ala Asn Lys Phe Gln Gly Met Val Phe Asp
            1460                1465                1470        
Phe Val Thr Arg Gln Val Phe Asp Ile Ser Ile Met Ile Leu Ile Cys
        1475                1480                1485            
Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln Gly Lys Tyr
    1490                1495                1500                
Met Thr Leu Val Leu Ser Arg Ile Asn Leu Val Phe Ile Val Leu Phe
1505                1510                1515                1520
Thr Gly Glu Phe Val Leu Lys Leu Val Ser Leu Arg His Tyr Tyr Phe
                1525                1530                1535    
Thr Ile Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser Ile
            1540                1545                1550        
Val Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr Phe Val Ser Pro
        1555                1560                1565            
Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu Arg
    1570                1575                1580                
Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu Met
1585                1590                1595                1600
Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu Val
                1605                1610                1615    
Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr Val Lys
            1620                1625                1630        
Lys Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Glu Thr Phe Gly Asn
        1635                1640                1645            
Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp Gly
    1650                1655                1660                
Leu Leu Ala Pro Ile Leu Asn Ser Ala Pro Pro Asp Cys Asp Pro Asp
1665                1670                1675                1680
Thr Ile His Pro Gly Ser Ser Val Lys Gly Asp Cys Gly Asn Pro Ser
                1685                1690                1695    
Val Gly Ile Phe Phe Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Val
            1700                1705                1710        
Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val Ala
        1715                1720                1725            
Thr Glu Glu Ser Ala Glu Pro Leu Ser Glu Asp Asp Phe Glu Met Phe
    1730                1735                1740                
Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile Glu
1745                1750                1755                1760
Phe Ser Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu Leu
                1765                1770                1775    
Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro Met
            1780                1785                1790        
Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala Phe Thr
        1795                1800                1805            
Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Arg Ile Gln
    1810                1815                1820                
Met Glu Asp Arg Phe Met Ala Ser Asn Pro Ser Lys Val Ser Tyr Glu
1825                1830                1835                1840
Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu Val Ser Ala Ala
                1845                1850                1855    
Ile Ile Gln Arg Asn Phe Arg Cys Tyr Leu Leu Lys Gln Arg Leu Lys
            1860                1865                1870        
Asn Ile Ser Ser Asn Tyr Asn Lys Glu Ala Ile Lys Gly Arg Ile Asp
        1875                1880                1885            
Leu Pro Ile Lys Gln Asp Met Ile Ile Asp Lys Leu Asn Gly Asn Ser
    1890                1895                1900                
Thr Pro Glu Lys Thr Asp Gly Ser Ser Ser Thr Thr Ser Pro Pro Ser
1905                1910                1915                1920
Tyr Asp Ser Val Thr Lys Pro Asp Lys Glu Lys Phe Glu Lys Asp Lys
                1925                1930                1935    
Pro Glu Lys Glu Ser Lys Gly Lys Glu Val Arg Glu Asn Gln Lys
            1940                1945                1950    


<210> 9217
<211> 424
<212> PRT
<213> Homo sapiens

<400> 9217
Met Leu Ala Arg Lys Ser Ile Ile Pro Glu Glu Tyr Val Leu Ala Arg
 1               5                  10                  15      
Ile Ala Ala Glu Asn Leu Arg Lys Pro Arg Ile Arg Asp Arg Leu Pro
            20                  25                  30          
Lys Ala Arg Phe Ile Ala Lys Ser Gly Ala Cys Asn Leu Ala His Lys
        35                  40                  45              
Asn Ile Arg Glu Gln Gly Arg Phe Leu Gln Asp Ile Phe Thr Thr Leu
    50                  55                  60                  
Val Asp Leu Lys Trp Arg His Thr Leu Val Ile Phe Thr Met Ser Phe
65                  70                  75                  80  
Leu Cys Ser Trp Leu Leu Phe Ala Ile Met Trp Trp Leu Val Ala Phe
                85                  90                  95      
Ala His Gly Asp Ile Tyr Ala Tyr Met Glu Lys Ser Gly Met Glu Lys
            100                 105                 110         
Ser Gly Leu Glu Ser Thr Val Cys Val Thr Asn Val Arg Ser Phe Thr
        115                 120                 125             
Ser Ala Phe Leu Phe Ser Ile Glu Val Gln Val Thr Ile Gly Phe Gly
    130                 135                 140                 
Gly Arg Met Met Thr Glu Glu Cys Pro Leu Ala Ile Thr Val Leu Ile
145                 150                 155                 160 
Leu Gln Asn Ile Val Gly Leu Ile Ile Asn Ala Val Met Leu Gly Cys
                165                 170                 175     
Ile Phe Met Lys Thr Ala Gln Ala His Arg Arg Ala Glu Thr Leu Ile
            180                 185                 190         
Phe Ser Arg His Ala Val Ile Ala Val Arg Asn Gly Lys Leu Cys Phe
        195                 200                 205             
Met Phe Arg Val Gly Asp Leu Arg Lys Ser Met Ile Ile Ser Ala Ser
    210                 215                 220                 
Val Arg Ile Gln Val Val Lys Lys Thr Thr Thr Pro Glu Gly Glu Val
225                 230                 235                 240 
Val Pro Ile His Gln Leu Asp Ile Pro Val Asp Asn Pro Ile Glu Ser
                245                 250                 255     
Asn Asn Ile Phe Leu Val Ala Pro Leu Ile Ile Cys His Val Ile Asp
            260                 265                 270         
Lys Arg Ser Pro Leu Tyr Asp Ile Ser Ala Thr Asp Leu Ala Asn Gln
        275                 280                 285             
Asp Leu Glu Val Ile Val Ile Leu Glu Gly Val Val Glu Thr Thr Gly
    290                 295                 300                 
Ile Thr Thr Gln Ala Arg Thr Ser Tyr Ile Ala Glu Glu Ile Gln Trp
305                 310                 315                 320 
Gly His Arg Phe Val Ser Ile Val Thr Glu Glu Glu Gly Val Tyr Ser
                325                 330                 335     
Val Asp Tyr Ser Lys Phe Gly Asn Thr Val Lys Val Ala Ala Pro Arg
            340                 345                 350         
Cys Ser Ala Arg Glu Leu Asp Glu Lys Pro Ser Ile Leu Ile Gln Thr
        355                 360                 365             
Leu Gln Lys Ser Glu Leu Ser His Gln Asn Ser Leu Arg Lys Arg Asn
    370                 375                 380                 
Ser Met Arg Arg Asn Asn Ser Met Arg Arg Asn Asn Ser Ile Arg Arg
385                 390                 395                 400 
Asn Asn Ser Ser Leu Met Val Pro Lys Val Gln Phe Met Thr Pro Glu
                405                 410                 415     
Gly Asn Gln Asn Thr Ser Glu Ser
            420                 


<210> 9218
<211> 311
<212> PRT
<213> Homo sapiens

<400> 9218
Met Arg Arg Asn Cys Thr Leu Val Thr Glu Phe Ile Leu Leu Gly Leu
 1               5                  10                  15      
Thr Ser Arg Arg Glu Leu Gln Ile Leu Leu Phe Thr Leu Phe Leu Ala
            20                  25                  30          
Ile Tyr Met Val Thr Val Ala Gly Asn Leu Gly Met Ile Val Leu Ile
        35                  40                  45              
Gln Ala Asn Ala Trp Leu His Met Pro Met Tyr Phe Phe Leu Ser His
    50                  55                  60                  
Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Asn Val Thr Pro Lys Met
65                  70                  75                  80  
Leu Glu Ile Phe Leu Ser Glu Lys Lys Ser Ile Ser Tyr Pro Ala Cys
                85                  90                  95      
Leu Val Gln Cys Tyr Leu Phe Ile Ala Leu Val His Val Glu Ile Tyr
            100                 105                 110         
Ile Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro
        115                 120                 125             
Leu Leu Tyr Gly Ser Arg Met Ser Lys Ser Val Cys Ser Phe Leu Ile
    130                 135                 140                 
Thr Val Pro Tyr Val Tyr Gly Ala Leu Thr Gly Leu Met Glu Thr Met
145                 150                 155                 160 
Trp Thr Tyr Asn Leu Ala Phe Cys Gly Pro Asn Glu Ile Asn His Phe
                165                 170                 175     
Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ala Cys Ser Asp Thr Tyr
            180                 185                 190         
Asn Lys Glu Leu Ser Met Phe Ile Val Ala Gly Trp Asn Leu Ser Phe
        195                 200                 205             
Ser Leu Phe Ile Ile Cys Ile Ser Tyr Leu Tyr Ile Phe Pro Ala Ile
    210                 215                 220                 
Leu Lys Ile Arg Ser Thr Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys
225                 230                 235                 240 
Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Ala Thr Leu Phe Phe
                245                 250                 255     
Met Tyr Leu Arg Pro Pro Ser Lys Glu Ser Val Glu Gln Gly Lys Met
            260                 265                 270         
Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Leu Ile Ile
        275                 280                 285             
Tyr Ser Leu Arg Asn Lys Asn Val Lys Glu Ala Leu Ile Lys Glu Leu
    290                 295                 300                 
Ser Met Lys Ile Tyr Phe Ser
305                 310     


<210> 9219
<211> 461
<212> PRT
<213> Homo sapiens

<400> 9219
Met Lys Ile Leu Phe Val Glu Pro Ala Ile Phe Leu Ser Ala Phe Ala
 1               5                  10                  15      
Met Thr Leu Thr Gly Pro Leu Thr Thr Gln Tyr Val Tyr Arg Arg Ile
            20                  25                  30          
Trp Glu Glu Thr Gly Asn Tyr Thr Phe Ser Ser Asp Ser Asn Ile Ser
        35                  40                  45              
Glu Cys Glu Lys Asn Lys Ser Ser Pro Ile Phe Ala Phe Gln Glu Glu
    50                  55                  60                  
Val Gln Lys Lys Val Ser Arg Phe Asn Leu Gln Met Asp Ile Ser Gly
65                  70                  75                  80  
Leu Ile Pro Gly Leu Val Ser Thr Phe Ile Leu Leu Ser Ile Ser Asp
                85                  90                  95      
His Tyr Gly Arg Lys Phe Pro Met Ile Leu Ser Ser Val Gly Ala Leu
            100                 105                 110         
Ala Thr Ser Val Trp Leu Cys Leu Leu Cys Tyr Phe Ala Phe Pro Phe
        115                 120                 125             
Gln Leu Leu Ile Ala Ser Thr Phe Ile Gly Ala Phe Cys Gly Asn Tyr
    130                 135                 140                 
Thr Thr Phe Trp Gly Ala Cys Phe Ala Tyr Ile Val Asp Gln Cys Lys
145                 150                 155                 160 
Glu His Lys Gln Lys Thr Ile Arg Ile Ala Ile Ile Asp Phe Leu Leu
                165                 170                 175     
Gly Leu Val Thr Gly Leu Thr Gly Leu Ser Ser Gly Tyr Phe Ile Arg
            180                 185                 190         
Glu Leu Gly Phe Glu Trp Ser Phe Leu Ile Ile Ala Val Ser Leu Ala
        195                 200                 205             
Val Asn Leu Ile Tyr Ile Leu Phe Phe Leu Gly Asp Pro Val Lys Glu
    210                 215                 220                 
Cys Ser Ser Gln Asn Val Thr Met Ser Cys Ser Glu Gly Phe Lys Asn
225                 230                 235                 240 
Leu Phe Tyr Arg Thr Tyr Met Leu Phe Lys Asn Ala Ser Gly Lys Arg
                245                 250                 255     
Arg Phe Leu Leu Cys Leu Leu Leu Phe Thr Val Ile Thr Tyr Phe Phe
            260                 265                 270         
Val Val Ile Gly Ile Ala Pro Ile Phe Ile Leu Tyr Glu Leu Asp Ser
        275                 280                 285             
Pro Leu Cys Trp Asn Glu Val Phe Ile Gly Tyr Gly Ser Ala Leu Gly
    290                 295                 300                 
Ser Ala Ser Phe Leu Thr Ser Phe Leu Gly Ile Trp Leu Phe Ser Tyr
305                 310                 315                 320 
Cys Met Glu Asp Ile His Met Ala Phe Ile Gly Ile Phe Thr Thr Met
                325                 330                 335     
Thr Gly Met Ala Met Thr Ala Phe Ala Ser Thr Thr Leu Met Met Phe
            340                 345                 350         
Leu Ala Arg Val Pro Phe Leu Phe Thr Ile Val Pro Phe Ser Val Leu
        355                 360                 365             
Arg Ser Met Leu Ser Lys Val Val Arg Ser Thr Glu Gln Gly Thr Leu
    370                 375                 380                 
Phe Ala Cys Ile Ala Phe Leu Glu Thr Leu Gly Gly Val Thr Ala Val
385                 390                 395                 400 
Ser Thr Phe Asn Gly Ile Tyr Ser Ala Thr Val Ala Trp Tyr Pro Gly
                405                 410                 415     
Phe Thr Phe Leu Leu Ser Ala Gly Leu Leu Leu Leu Pro Ala Ile Ser
            420                 425                 430         
Leu Cys Val Val Lys Cys Thr Ser Trp Asn Glu Gly Ser Tyr Glu Leu
        435                 440                 445             
Leu Ile Gln Glu Glu Ser Ser Glu Asp Ala Ser Asp Arg
    450                 455                 460     


<210> 9220
<211> 386
<212> PRT
<213> Homo sapiens

<400> 9220
Met Asn Glu Pro Thr Glu Asn Arg Leu Gly Cys Ser Arg Thr Pro Glu
 1               5                  10                  15      
Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Thr Arg Arg
            20                  25                  30          
Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala
        35                  40                  45              
Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr
    50                  55                  60                  
Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro
65                  70                  75                  80  
Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys
                85                  90                  95      
Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro
            100                 105                 110         
Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro
        115                 120                 125             
Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr
    130                 135                 140                 
Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe Leu
145                 150                 155                 160 
Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala
                165                 170                 175     
Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile
            180                 185                 190         
Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser
        195                 200                 205             
Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala
    210                 215                 220                 
Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr
225                 230                 235                 240 
Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu
                245                 250                 255     
Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro
            260                 265                 270         
Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser
        275                 280                 285             
Gly Ile Ile Pro Thr Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys
    290                 295                 300                 
Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu
305                 310                 315                 320 
Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe
                325                 330                 335     
Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His
            340                 345                 350         
Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn
        355                 360                 365             
Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp
    370                 375                 380                 
Ala Leu
385     


<210> 9221
<211> 2044
<212> PRT
<213> Homo sapiens

<400> 9221
Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys
 1               5                  10                  15      
Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys
            20                  25                  30          
Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu
        35                  40                  45              
Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser
    50                  55                  60                  
Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu
65                  70                  75                  80  
Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser
                85                  90                  95      
Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln
            100                 105                 110         
Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser
        115                 120                 125             
Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly
    130                 135                 140                 
Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala
145                 150                 155                 160 
Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala
                165                 170                 175     
Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu
            180                 185                 190         
Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly
        195                 200                 205             
Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val
    210                 215                 220                 
Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe
225                 230                 235                 240 
Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu
                245                 250                 255     
Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg
            260                 265                 270         
Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr
        275                 280                 285             
Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp
    290                 295                 300                 
Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met
305                 310                 315                 320 
Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg
                325                 330                 335     
Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly
            340                 345                 350         
Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu
        355                 360                 365             
Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile
    370                 375                 380                 
Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu
385                 390                 395                 400 
Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn
                405                 410                 415     
Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro
            420                 425                 430         
Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu
        435                 440                 445             
Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile
    450                 455                 460                 
Ala Ala Ser Gly Gly Glu Val Glu Val Asn Thr Gly Glu Thr Glu Val
465                 470                 475                 480 
Gly Phe Val Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser
                485                 490                 495     
Pro Arg Glu Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr
            500                 505                 510         
Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu
        515                 520                 525             
Ala Thr Phe Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile
    530                 535                 540                 
Ser Asn Asp Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys
545                 550                 555                 560 
Tyr Ser Leu Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val
                565                 570                 575     
Gly Glu Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys
            580                 585                 590         
Phe Asp Thr Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg
        595                 600                 605             
Ala Val Phe Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr
    610                 615                 620                 
Lys Pro Val Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg
625                 630                 635                 640 
Leu Asp Ala Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr
                645                 650                 655     
Asn Ile Glu Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn
            660                 665                 670         
Gln Leu Ala Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp
        675                 680                 685             
Thr Arg Tyr Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val
    690                 695                 700                 
Leu Asp Thr Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile
705                 710                 715                 720 
His Glu Ala Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser
                725                 730                 735     
Thr Leu Ala Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr
            740                 745                 750         
Glu Glu Pro Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg
        755                 760                 765             
Gly Glu Lys Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu
    770                 775                 780                 
Tyr Ser Thr Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr
785                 790                 795                 800 
Gln Thr Ile Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys
                805                 810                 815     
Val Pro Val Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val
            820                 825                 830         
Glu Lys Lys Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala
        835                 840                 845             
Glu Met Tyr Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser
    850                 855                 860                 
Gly Leu Val Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys
865                 870                 875                 880 
Leu Lys Arg Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly
                885                 890                 895     
Glu Trp Ile Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala
            900                 905                 910         
Gly His Thr Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr
        915                 920                 925             
Pro Gly Gly Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn
    930                 935                 940                 
Gly Asp Lys Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp
945                 950                 955                 960 
Glu Trp Glu Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp
                965                 970                 975     
Glu Lys Gly Trp Glu Tyr Gly Ile Thr Ile Pro Pro Asp His Lys Pro
            980                 985                 990         
Lys Ser Trp Val Ala Ala Glu Lys Met Tyr His Thr His Arg Arg Arg
        995                 1000                1005            
Arg Leu Val Arg Lys Arg Lys Lys Asp Leu Thr Gln Thr Ala Ser Ser
    1010                1015                1020                
Thr Ala Arg Ala Met Glu Glu Leu Gln Asp Gln Glu Gly Trp Glu Tyr
1025                1030                1035                1040
Ala Ser Leu Ile Gly Trp Lys Phe His Trp Lys Gln Arg Ser Ser Asp
                1045                1050                1055    
Thr Phe Arg Arg Arg Arg Trp Arg Arg Lys Met Ala Pro Ser Glu Thr
            1060                1065                1070        
His Gly Ala Ala Ala Ile Phe Lys Leu Glu Gly Ala Leu Gly Ala Asp
        1075                1080                1085            
Thr Thr Glu Asp Gly Asp Glu Lys Ser Leu Glu Lys Gln Lys His Ser
    1090                1095                1100                
Ala Thr Thr Val Phe Gly Ala Asn Thr Pro Ile Val Ser Cys Asn Phe
1105                1110                1115                1120
Asp Arg Val Tyr Ile Tyr His Leu Arg Cys Tyr Val Tyr Gln Ala Arg
                1125                1130                1135    
Asn Leu Leu Ala Leu Asp Lys Asp Ser Phe Ser Asp Pro Tyr Ala His
            1140                1145                1150        
Ile Cys Phe Leu His Arg Ser Lys Thr Thr Glu Ile Ile His Ser Thr
        1155                1160                1165            
Leu Asn Pro Thr Trp Asp Gln Thr Ile Ile Phe Asp Glu Val Glu Ile
    1170                1175                1180                
Tyr Gly Glu Pro Gln Thr Val Leu Gln Asn Pro Pro Lys Val Ile Met
1185                1190                1195                1200
Glu Leu Phe Asp Asn Asp Gln Val Gly Lys Asp Glu Phe Leu Gly Arg
                1205                1210                1215    
Ser Ile Phe Ser Pro Val Val Lys Leu Asn Ser Glu Met Asp Ile Thr
            1220                1225                1230        
Pro Lys Leu Leu Trp His Pro Val Met Asn Gly Asp Lys Ala Cys Gly
        1235                1240                1245            
Asp Val Leu Val Thr Ala Glu Leu Ile Leu Arg Gly Lys Asp Gly Ser
    1250                1255                1260                
Asn Leu Pro Ile Leu Pro Pro Gln Arg Ala Pro Asn Leu Tyr Met Val
1265                1270                1275                1280
Pro Gln Gly Ile Arg Pro Val Val Gln Leu Thr Ala Ile Glu Ile Leu
                1285                1290                1295    
Ala Trp Gly Leu Arg Asn Met Lys Asn Phe Gln Met Ala Ser Ile Thr
            1300                1305                1310        
Ser Pro Ser Leu Val Val Glu Cys Gly Gly Glu Arg Val Glu Ser Val
        1315                1320                1325            
Val Ile Lys Asn Leu Lys Lys Thr Pro Asn Phe Pro Ser Ser Val Leu
    1330                1335                1340                
Phe Met Lys Val Phe Leu Pro Lys Glu Glu Leu Tyr Met Pro Pro Leu
1345                1350                1355                1360
Val Ile Lys Val Ile Asp His Arg Gln Phe Gly Arg Lys Pro Val Val
                1365                1370                1375    
Gly Gln Cys Thr Ile Glu Arg Leu Asp Arg Phe Arg Cys Asp Pro Tyr
            1380                1385                1390        
Ala Gly Lys Glu Asp Ile Val Pro Gln Leu Lys Ala Ser Leu Leu Ser
        1395                1400                1405            
Ala Pro Pro Cys Arg Asp Ile Val Ile Glu Met Glu Asp Thr Lys Pro
    1410                1415                1420                
Leu Leu Ala Ser Lys Glu Glu Glu Ile Val Asp Trp Trp Ser Lys Phe
1425                1430                1435                1440
Tyr Ala Ser Ser Gly Glu His Glu Lys Cys Gly Gln Tyr Ile Gln Lys
                1445                1450                1455    
Gly Tyr Ser Lys Leu Lys Ile Tyr Asn Cys Glu Leu Glu Asn Val Ala
            1460                1465                1470        
Glu Phe Glu Gly Leu Thr Asp Phe Ser Asp Thr Phe Lys Leu Tyr Arg
        1475                1480                1485            
Gly Lys Ser Asp Glu Asn Glu Asp Pro Ser Val Val Gly Glu Phe Lys
    1490                1495                1500                
Gly Ser Phe Arg Ile Tyr Pro Leu Pro Asp Asp Pro Ser Val Pro Ala
1505                1510                1515                1520
Pro Pro Arg Gln Phe Arg Glu Leu Pro Asp Ser Val Pro Gln Glu Cys
                1525                1530                1535    
Thr Val Arg Ile Tyr Ile Val Arg Gly Leu Glu Leu Gln Pro Gln Asp
            1540                1545                1550        
Asn Asn Gly Leu Cys Asp Pro Tyr Ile Lys Ile Thr Leu Gly Lys Lys
        1555                1560                1565            
Val Ile Glu Asp Arg Asp His Tyr Ile Pro Asn Thr Leu Asn Pro Val
    1570                1575                1580                
Phe Gly Arg Met Tyr Glu Leu Ser Cys Tyr Leu Pro Gln Glu Lys Asp
1585                1590                1595                1600
Leu Lys Ile Ser Val Tyr Asp Tyr Asp Thr Phe Thr Arg Asp Glu Lys
                1605                1610                1615    
Val Gly Glu Thr Ile Ile Asp Leu Glu Asn Arg Phe Leu Ser Arg Phe
            1620                1625                1630        
Gly Ser His Cys Gly Ile Pro Glu Glu Tyr Cys Val Ser Gly Val Asn
        1635                1640                1645            
Thr Trp Arg Asp Gln Leu Arg Pro Thr Gln Leu Leu Gln Asn Val Ala
    1650                1655                1660                
Arg Phe Lys Gly Phe Pro Gln Pro Ile Leu Ser Glu Asp Gly Ser Arg
1665                1670                1675                1680
Ile Arg Tyr Gly Gly Arg Asp Tyr Ser Leu Asp Glu Phe Glu Ala Asn
                1685                1690                1695    
Lys Ile Leu His Gln His Leu Gly Ala Pro Glu Glu Arg Leu Ala Leu
            1700                1705                1710        
His Ile Leu Arg Thr Gln Gly Leu Val Pro Glu His Val Glu Thr Arg
        1715                1720                1725            
Thr Leu His Ser Thr Phe Gln Pro Asn Ile Ser Gln Gly Lys Leu Gln
    1730                1735                1740                
Met Trp Val Asp Val Phe Pro Lys Ser Leu Gly Pro Pro Gly Pro Pro
1745                1750                1755                1760
Phe Asn Ile Thr Pro Arg Lys Ala Lys Lys Tyr Tyr Leu Arg Val Ile
                1765                1770                1775    
Ile Trp Asn Thr Lys Asp Val Ile Leu Asp Glu Lys Ser Ile Thr Gly
            1780                1785                1790        
Glu Glu Met Ser Asp Ile Tyr Val Lys Gly Trp Ile Pro Gly Asn Glu
        1795                1800                1805            
Glu Asn Lys Gln Lys Thr Asp Val His Tyr Arg Ser Leu Asp Gly Glu
    1810                1815                1820                
Gly Asn Phe Asn Trp Arg Phe Val Phe Pro Phe Asp Tyr Leu Pro Ala
1825                1830                1835                1840
Glu Gln Leu Cys Ile Val Ala Lys Lys Glu His Phe Trp Ser Ile Asp
                1845                1850                1855    
Gln Thr Glu Phe Arg Ile Pro Pro Arg Leu Ile Ile Gln Ile Trp Asp
            1860                1865                1870        
Asn Asp Lys Phe Ser Leu Asp Asp Tyr Leu Gly Phe Leu Glu Leu Asp
        1875                1880                1885            
Leu Arg His Thr Ile Ile Pro Ala Lys Ser Pro Glu Lys Cys Arg Leu
    1890                1895                1900                
Asp Met Ile Pro Asp Leu Lys Ala Met Asn Pro Leu Lys Ala Lys Thr
1905                1910                1915                1920
Ala Ser Leu Phe Glu Gln Lys Ser Met Lys Gly Trp Trp Pro Cys Tyr
                1925                1930                1935    
Ala Glu Lys Asp Gly Ala Arg Val Met Ala Gly Lys Val Glu Met Thr
            1940                1945                1950        
Leu Glu Ile Leu Asn Glu Lys Glu Ala Asp Glu Arg Pro Ala Gly Lys
        1955                1960                1965            
Gly Arg Asp Glu Pro Asn Met Asn Pro Lys Leu Asp Leu Pro Asn Arg
    1970                1975                1980                
Pro Glu Thr Ser Phe Leu Trp Phe Thr Asn Pro Cys Lys Thr Met Lys
1985                1990                1995                2000
Phe Ile Val Trp Arg Arg Phe Lys Trp Val Ile Ile Gly Leu Leu Phe
                2005                2010                2015    
Leu Leu Ile Leu Leu Leu Phe Val Ala Val Leu Leu Tyr Ser Leu Pro
            2020                2025                2030        
Asn Tyr Leu Ser Met Lys Ile Val Lys Pro Asn Val
        2035                2040                


<210> 9222
<211> 1577
<212> PRT
<213> Homo sapiens

<400> 9222
Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys
 1               5                  10                  15      
Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys
            20                  25                  30          
Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu
        35                  40                  45              
Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser
    50                  55                  60                  
Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu
65                  70                  75                  80  
Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser
                85                  90                  95      
Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln
            100                 105                 110         
Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser
        115                 120                 125             
Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly
    130                 135                 140                 
Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala
145                 150                 155                 160 
Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala
                165                 170                 175     
Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu
            180                 185                 190         
Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly
        195                 200                 205             
Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val
    210                 215                 220                 
Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe
225                 230                 235                 240 
Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu
                245                 250                 255     
Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg
            260                 265                 270         
Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr
        275                 280                 285             
Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp
    290                 295                 300                 
Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met
305                 310                 315                 320 
Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg
                325                 330                 335     
Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly
            340                 345                 350         
Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu
        355                 360                 365             
Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile
    370                 375                 380                 
Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu
385                 390                 395                 400 
Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn
                405                 410                 415     
Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro
            420                 425                 430         
Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu
        435                 440                 445             
Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile
    450                 455                 460                 
Ala Ala Ser Gly Gly Glu Val Glu Asp Phe Ser Ser Ser Gly Thr Gly
465                 470                 475                 480 
Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu Thr Glu Val Gly Phe Val
                485                 490                 495     
Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser Pro Arg Glu
            500                 505                 510         
Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr Gly Lys Gly
        515                 520                 525             
Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu Ala Thr Phe
    530                 535                 540                 
Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile Ser Asn Asp
545                 550                 555                 560 
Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys Tyr Ser Leu
                565                 570                 575     
Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val Gly Glu Ala
            580                 585                 590         
Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp Thr
        595                 600                 605             
Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val Phe
    610                 615                 620                 
Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr Lys Pro Val
625                 630                 635                 640 
Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg Leu Asp Ala
                645                 650                 655     
Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr Asn Ile Glu
            660                 665                 670         
Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn Gln Leu Ala
        675                 680                 685             
Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp Thr Arg Tyr
    690                 695                 700                 
Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val Leu Asp Thr
705                 710                 715                 720 
Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile His Glu Ala
                725                 730                 735     
Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser Thr Leu Ala
            740                 745                 750         
Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr Glu Glu Pro
        755                 760                 765             
Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg Gly Glu Lys
    770                 775                 780                 
Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu Tyr Ser Thr
785                 790                 795                 800 
Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr Gln Thr Ile
                805                 810                 815     
Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys Val Pro Val
            820                 825                 830         
Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val Glu Lys Lys
        835                 840                 845             
Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala Glu Met Tyr
    850                 855                 860                 
Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser Gly Leu Val
865                 870                 875                 880 
Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu Lys Arg
                885                 890                 895     
Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly Glu Trp Ile
            900                 905                 910         
Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala Gly His Thr
        915                 920                 925             
Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr Pro Gly Gly
    930                 935                 940                 
Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn Gly Asp Lys
945                 950                 955                 960 
Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp Glu Trp Glu
                965                 970                 975     
Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp Glu Lys Gly
            980                 985                 990         
Trp Glu Tyr Gly Ile Thr Ile Pro Pro Asp His Lys Pro Lys Ser Trp
        995                 1000                1005            
Val Ala Ala Glu Lys Met Tyr His Thr His Arg Arg Arg Arg Leu Val
    1010                1015                1020                
Arg Lys Arg Lys Lys Asp Leu Thr Gln Thr Ala Ser Ser Thr Ala Arg
1025                1030                1035                1040
Ala Met Glu Glu Leu Gln Asp Gln Glu Gly Trp Glu Tyr Ala Ser Leu
                1045                1050                1055    
Ile Gly Trp Lys Phe His Trp Lys Gln Arg Ser Ser Asp Thr Phe Arg
            1060                1065                1070        
Arg Arg Arg Trp Arg Arg Lys Met Ala Pro Ser Glu Thr His Gly Ala
        1075                1080                1085            
Ala Ala Ile Phe Lys Leu Glu Gly Ala Leu Gly Ala Asp Thr Thr Glu
    1090                1095                1100                
Asp Gly Asp Glu Lys Ser Leu Glu Lys Gln Lys His Ser Ala Thr Thr
1105                1110                1115                1120
Val Phe Gly Ala Asn Thr Pro Ile Val Ser Cys Asn Phe Asp Arg Val
                1125                1130                1135    
Tyr Ile Tyr His Leu Arg Cys Tyr Val Tyr Gln Ala Arg Asn Leu Leu
            1140                1145                1150        
Ala Leu Asp Lys Asp Ser Phe Ser Asp Pro Tyr Ala His Ile Cys Phe
        1155                1160                1165            
Leu His Arg Ser Lys Thr Thr Glu Ile Ile His Ser Thr Leu Asn Pro
    1170                1175                1180                
Thr Trp Asp Gln Thr Ile Ile Phe Asp Glu Val Glu Ile Tyr Gly Glu
1185                1190                1195                1200
Pro Gln Thr Val Leu Gln Asn Pro Pro Lys Val Ile Met Glu Leu Phe
                1205                1210                1215    
Asp Asn Asp Gln Val Gly Lys Asp Glu Phe Glu Ala Asn Lys Ile Leu
            1220                1225                1230        
His Gln His Leu Gly Ala Pro Glu Glu Arg Leu Ala Leu His Ile Leu
        1235                1240                1245            
Arg Thr Gln Gly Leu Val Pro Glu His Val Glu Thr Arg Thr Leu His
    1250                1255                1260                
Ser Thr Phe Gln Pro Asn Ile Ser Gln Gly Lys Leu Gln Met Trp Val
1265                1270                1275                1280
Asp Val Phe Pro Lys Ser Leu Gly Pro Pro Gly Pro Pro Phe Asn Ile
                1285                1290                1295    
Thr Pro Arg Lys Ala Lys Lys Tyr Tyr Leu Arg Val Ile Ile Trp Asn
            1300                1305                1310        
Thr Lys Asp Val Ile Leu Asp Glu Lys Ser Ile Thr Gly Glu Glu Met
        1315                1320                1325            
Ser Asp Ile Tyr Val Lys Gly Trp Ile Pro Gly Asn Glu Glu Asn Lys
    1330                1335                1340                
Gln Lys Thr Asp Val His Tyr Arg Ser Leu Asp Gly Glu Gly Asn Phe
1345                1350                1355                1360
Asn Trp Arg Phe Val Phe Pro Phe Asp Tyr Leu Pro Ala Glu Gln Leu
                1365                1370                1375    
Cys Ile Val Ala Lys Lys Glu His Phe Trp Ser Ile Asp Gln Thr Glu
            1380                1385                1390        
Phe Arg Ile Pro Pro Arg Leu Ile Ile Gln Ile Trp Asp Asn Asp Lys
        1395                1400                1405            
Phe Ser Leu Asp Asp Tyr Leu Gly Phe Leu Glu Leu Asp Leu Arg His
    1410                1415                1420                
Thr Ile Ile Pro Ala Lys Ser Pro Glu Lys Cys Arg Leu Asp Met Ile
1425                1430                1435                1440
Pro Asp Leu Lys Ala Met Asn Pro Leu Lys Ala Lys Thr Ala Ser Leu
                1445                1450                1455    
Phe Glu Gln Lys Ser Met Lys Gly Trp Trp Pro Cys Tyr Ala Glu Lys
            1460                1465                1470        
Asp Gly Ala Arg Val Met Ala Gly Lys Val Glu Met Thr Leu Glu Ile
        1475                1480                1485            
Leu Asn Glu Lys Glu Ala Asp Glu Arg Pro Ala Gly Lys Gly Arg Asp
    1490                1495                1500                
Glu Pro Asn Met Asn Pro Lys Leu Asp Leu Pro Asn Arg Pro Glu Thr
1505                1510                1515                1520
Ser Phe Leu Trp Phe Thr Asn Pro Cys Lys Thr Met Lys Phe Ile Val
                1525                1530                1535    
Trp Arg Arg Phe Lys Trp Val Ile Ile Gly Leu Leu Phe Leu Leu Ile
            1540                1545                1550        
Leu Leu Leu Phe Val Ala Val Leu Leu Tyr Ser Leu Pro Asn Tyr Leu
        1555                1560                1565            
Ser Met Lys Ile Val Lys Pro Asn Val
    1570                1575        


<210> 9223
<211> 2019
<212> PRT
<213> Homo sapiens

<400> 9223
Met Arg Pro Pro Lys Glu Gly Ser Gly Ser Asn Ile Cys Cys Ser Ala
 1               5                  10                  15      
Ile Phe Ala Val Leu Gln Pro Pro Leu Val Ile Ser Arg Gln Thr Arg
            20                  25                  30          
Ser Gly Met Asp Leu Gln Gln Thr Pro Thr Asp Leu Gln Leu Lys Asp
        35                  40                  45              
Leu Thr Gly Asp Gln Ser Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu
    50                  55                  60                  
Leu Asn Glu Lys Gly Gln Asp Thr Gly Ala Thr Ile Asp Leu Val Ile
65                  70                  75                  80  
Gly Tyr Asp Pro Pro Ser Ala Pro His Pro Asn Asp Leu Ser Gly Pro
                85                  90                  95      
Ser Val Pro Gly Met Gly Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu
            100                 105                 110         
Asp Arg Leu Asp Asn Ala Val Arg Gly Pro Gly Pro Lys Gly Pro Val
        115                 120                 125             
Gly Thr Val Ser Glu Ala Gln Leu Ala Arg Arg Leu Thr Lys Val Lys
    130                 135                 140                 
Asn Ser Arg Arg Met Leu Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg
145                 150                 155                 160 
Val Arg Val Ile Glu Gly Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro
                165                 170                 175     
Val Val Lys Val His Val Cys Gly Gln Thr His Arg Thr Arg Ile Lys
            180                 185                 190         
Arg Gly Asn Asn Pro Phe Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn
        195                 200                 205             
Met Thr Pro Ser Glu Leu Met Asp Glu Ile Ile Ser Ile Arg Val Tyr
    210                 215                 220                 
Asn Ser His Ser Leu Arg Ala Asp Cys Leu Met Gly Glu Phe Lys Ile
225                 230                 235                 240 
Asp Val Gly Phe Val Tyr Asp Glu Pro Gly His Ala Val Met Arg Lys
                245                 250                 255     
Trp Leu Leu Leu Asn Asp Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly
            260                 265                 270         
Tyr Met Lys Val Ser Met Phe Val Leu Gly Thr Gly Asp Glu Pro Pro
        275                 280                 285             
Pro Glu Arg Arg Asp Arg Asp Asn Asp Ser Asp Asp Val Glu Ser Asn
    290                 295                 300                 
Leu Leu Leu Pro Ala Gly Ile Ala Leu Arg Trp Val Thr Phe Leu Leu
305                 310                 315                 320 
Lys Ile Tyr Arg Ala Glu Asp Ile Pro Gln Met Asp Asp Ala Phe Ser
                325                 330                 335     
Gln Thr Val Lys Glu Ile Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu
            340                 345                 350         
Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Lys Val Cys Thr
        355                 360                 365             
Asn Ile Ile Glu Lys Asn Ala Asn Pro Glu Trp Asn Gln Val Val Asn
    370                 375                 380                 
Leu Gln Ile Lys Phe Pro Ser Val Cys Glu Lys Ile Lys Leu Thr Ile
385                 390                 395                 400 
Tyr Asp Trp Asp Arg Leu Thr Lys Asn Asp Val Val Gly Thr Thr Tyr
                405                 410                 415     
Leu His Leu Ser Lys Ile Ala Ala Ser Gly Gly Glu Val Glu Asp Phe
            420                 425                 430         
Ser Ser Ser Gly Thr Gly Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu
        435                 440                 445             
Thr Glu Val Gly Phe Val Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu
    450                 455                 460                 
Tyr Gly Ser Pro Arg Glu Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu
465                 470                 475                 480 
Leu Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu
                485                 490                 495     
Val Glu Leu Ala Thr Phe Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu
            500                 505                 510         
Glu Pro Ile Ser Asn Asp Asp Leu Leu Val Val Glu Lys Tyr Gln Arg
        515                 520                 525             
Arg Arg Lys Tyr Ser Leu Ser Ala Val Phe His Ser Ala Thr Met Leu
    530                 535                 540                 
Gln Asp Val Gly Glu Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr
545                 550                 555                 560 
Gly Asn Lys Phe Asp Thr Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln
                565                 570                 575     
Tyr Ser Arg Ala Val Phe Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp
            580                 585                 590         
Ala His Thr Lys Pro Val Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile
        595                 600                 605             
Ser His Arg Leu Asp Ala Val Asn Thr Leu Leu Ala Met Ala Glu Arg
    610                 615                 620                 
Leu Gln Thr Asn Ile Glu Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile
625                 630                 635                 640 
Pro Ala Asn Gln Leu Ala Glu Leu Trp Leu Lys Leu Ile Asp Glu Val
                645                 650                 655     
Ile Glu Asp Thr Arg Tyr Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn
            660                 665                 670         
Val Thr Val Leu Asp Thr Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu
        675                 680                 685             
Ser Gln Ile His Glu Ala Ala Val Arg Met Arg Ser Glu Ala Thr Asp
    690                 695                 700                 
Val Lys Ser Thr Leu Ala Glu Ile Glu Asp Trp Leu Asp Lys Leu Met
705                 710                 715                 720 
Gln Leu Thr Glu Glu Pro Gln Asn Ser Met Pro Asp Ile Ile Ile Trp
                725                 730                 735     
Met Ile Arg Gly Glu Lys Arg Leu Ala Tyr Ala Arg Ile Pro Ala His
            740                 745                 750         
Gln Val Leu Tyr Ser Thr Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys
        755                 760                 765             
Gly Lys Thr Gln Thr Ile Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn
    770                 775                 780                 
Gly Pro Lys Val Pro Val Glu Leu Arg Val Asn Ile Trp Leu Gly Leu
785                 790                 795                 800 
Ser Ala Val Glu Lys Lys Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr
                805                 810                 815     
Val Phe Ala Glu Met Tyr Glu Asn Gln Ala Leu Met Phe Gly Lys Trp
            820                 825                 830         
Gly Thr Ser Gly Leu Val Gly Arg His Lys Phe Ser Asp Val Thr Gly
        835                 840                 845             
Lys Ile Lys Leu Lys Arg Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu
    850                 855                 860                 
Trp Glu Gly Glu Trp Ile Val Asp Pro Glu Arg Ser Leu Leu Thr Glu
865                 870                 875                 880 
Ala Asp Ala Gly His Thr Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu
                885                 890                 895     
Ser Arg Tyr Pro Gly Gly Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr
            900                 905                 910         
Asp Ala Asn Gly Asp Lys Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro
        915                 920                 925             
Pro Gly Trp Glu Trp Glu Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg
    930                 935                 940                 
Ala Val Asp Glu Lys Gly Trp Glu Tyr Gly Ile Thr Ile Pro Pro Asp
945                 950                 955                 960 
His Lys Pro Lys Ser Trp Val Ala Ala Glu Lys Met Tyr His Thr His
                965                 970                 975     
Arg Arg Arg Arg Leu Val Arg Lys Arg Lys Lys Asp Leu Thr Gln Thr
            980                 985                 990         
Ala Ser Ser Thr Ala Arg Ala Met Glu Glu Leu Gln Asp Gln Glu Gly
        995                 1000                1005            
Trp Glu Tyr Ala Ser Leu Ile Gly Trp Lys Phe His Trp Lys Gln Arg
    1010                1015                1020                
Ser Ser Asp Thr Phe Arg Arg Arg Arg Trp Arg Arg Lys Met Ala Pro
1025                1030                1035                1040
Ser Glu Thr His Gly Ala Ala Ala Ile Phe Lys Leu Glu Gly Ala Leu
                1045                1050                1055    
Gly Ala Asp Thr Thr Glu Asp Gly Asp Glu Lys Ser Leu Glu Lys Gln
            1060                1065                1070        
Lys His Ser Ala Thr Thr Val Phe Gly Ala Asn Thr Pro Ile Val Ser
        1075                1080                1085            
Cys Asn Phe Asp Arg Val Tyr Ile Tyr His Leu Arg Cys Tyr Val Tyr
    1090                1095                1100                
Gln Ala Arg Asn Leu Leu Ala Leu Asp Lys Asp Ser Phe Ser Asp Pro
1105                1110                1115                1120
Tyr Ala His Ile Cys Phe Leu His Arg Ser Lys Thr Thr Glu Ile Ile
                1125                1130                1135    
His Ser Thr Leu Asn Pro Thr Trp Asp Gln Thr Ile Ile Phe Asp Glu
            1140                1145                1150        
Val Glu Ile Tyr Gly Glu Pro Gln Thr Val Leu Gln Asn Pro Pro Lys
        1155                1160                1165            
Val Ile Met Glu Leu Phe Asp Asn Asp Gln Val Gly Lys Asp Glu Phe
    1170                1175                1180                
Leu Gly Arg Ser Ile Phe Ser Pro Val Val Lys Leu Asn Ser Glu Met
1185                1190                1195                1200
Asp Ile Thr Pro Lys Leu Leu Trp His Pro Val Met Asn Gly Asp Lys
                1205                1210                1215    
Ala Cys Gly Asp Val Leu Val Thr Ala Glu Leu Ile Leu Arg Gly Lys
            1220                1225                1230        
Asp Gly Ser Asn Leu Pro Ile Leu Pro Pro Gln Arg Ala Pro Asn Leu
        1235                1240                1245            
Tyr Met Val Pro Gln Gly Ile Arg Pro Val Val Gln Leu Thr Ala Ile
    1250                1255                1260                
Glu Ile Leu Ala Trp Gly Leu Arg Asn Met Lys Asn Phe Gln Met Ala
1265                1270                1275                1280
Ser Ile Thr Ser Pro Ser Leu Val Val Glu Cys Gly Gly Glu Arg Val
                1285                1290                1295    
Glu Ser Val Val Ile Lys Asn Leu Lys Lys Thr Pro Asn Phe Pro Ser
            1300                1305                1310        
Ser Val Leu Phe Met Lys Val Phe Leu Pro Lys Glu Glu Leu Tyr Met
        1315                1320                1325            
Pro Pro Leu Val Ile Lys Val Ile Asp His Arg Gln Phe Gly Arg Lys
    1330                1335                1340                
Pro Val Val Gly Gln Cys Thr Ile Glu Arg Leu Asp Arg Phe Arg Cys
1345                1350                1355                1360
Asp Pro Tyr Ala Gly Lys Glu Asp Ile Val Pro Gln Leu Lys Ala Ser
                1365                1370                1375    
Leu Leu Ser Ala Pro Pro Cys Arg Asp Ile Val Ile Glu Met Glu Asp
            1380                1385                1390        
Thr Lys Pro Leu Leu Ala Ser Lys Leu Thr Glu Lys Glu Glu Glu Ile
        1395                1400                1405            
Val Asp Trp Trp Ser Lys Phe Tyr Ala Ser Ser Gly Glu His Glu Lys
    1410                1415                1420                
Cys Gly Gln Tyr Ile Gln Lys Gly Tyr Ser Lys Leu Lys Ile Tyr Asn
1425                1430                1435                1440
Cys Glu Leu Glu Asn Val Ala Glu Phe Glu Gly Leu Thr Asp Phe Ser
                1445                1450                1455    
Asp Thr Phe Lys Leu Tyr Arg Gly Lys Ser Asp Glu Asn Glu Asp Pro
            1460                1465                1470        
Ser Val Val Gly Glu Phe Lys Gly Ser Phe Arg Ile Tyr Pro Leu Pro
        1475                1480                1485            
Asp Asp Pro Ser Val Pro Ala Pro Pro Arg Gln Phe Arg Glu Leu Pro
    1490                1495                1500                
Asp Ser Val Pro Gln Glu Cys Thr Val Arg Ile Tyr Ile Val Arg Gly
1505                1510                1515                1520
Leu Glu Leu Gln Pro Gln Asp Asn Asn Gly Leu Cys Asp Pro Tyr Ile
                1525                1530                1535    
Lys Ile Thr Leu Gly Lys Lys Val Ile Glu Asp Arg Asp His Tyr Ile
            1540                1545                1550        
Pro Asn Thr Leu Asn Pro Val Phe Gly Arg Met Tyr Glu Leu Ser Cys
        1555                1560                1565            
Tyr Leu Pro Gln Glu Lys Asp Leu Lys Ile Ser Val Tyr Asp Tyr Asp
    1570                1575                1580                
Thr Phe Thr Arg Asp Glu Lys Val Gly Glu Thr Ile Ile Asp Leu Glu
1585                1590                1595                1600
Asn Arg Phe Leu Ser Arg Phe Gly Ser His Cys Gly Ile Pro Glu Glu
                1605                1610                1615    
Tyr Cys Val Ser Gly Val Asn Thr Trp Arg Asp Gln Leu Arg Pro Thr
            1620                1625                1630        
Gln Leu Leu Gln Asn Val Ala Arg Phe Lys Gly Phe Pro Gln Pro Ile
        1635                1640                1645            
Leu Ser Glu Asp Gly Ser Arg Ile Arg Tyr Gly Gly Arg Asp Tyr Ser
    1650                1655                1660                
Leu Asp Glu Phe Glu Ala Asn Lys Ile Leu His Gln His Leu Gly Ala
1665                1670                1675                1680
Pro Glu Glu Arg Leu Ala Leu His Ile Leu Arg Thr Gln Gly Leu Val
                1685                1690                1695    
Pro Glu His Val Glu Thr Arg Thr Leu His Ser Thr Phe Gln Pro Asn
            1700                1705                1710        
Ile Ser Gln Gly Lys Leu Gln Met Trp Val Asp Val Phe Pro Lys Ser
        1715                1720                1725            
Leu Gly Pro Pro Gly Pro Pro Phe Asn Ile Thr Pro Arg Lys Ala Lys
    1730                1735                1740                
Lys Tyr Tyr Leu Arg Val Ile Ile Trp Asn Thr Lys Asp Val Ile Leu
1745                1750                1755                1760
Asp Glu Lys Ser Ile Thr Gly Glu Glu Met Ser Asp Ile Tyr Val Lys
                1765                1770                1775    
Gly Trp Ile Pro Gly Asn Glu Glu Asn Lys Gln Lys Thr Asp Val His
            1780                1785                1790        
Tyr Arg Ser Leu Asp Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe
        1795                1800                1805            
Pro Phe Asp Tyr Leu Pro Ala Glu Gln Leu Cys Ile Val Ala Lys Lys
    1810                1815                1820                
Glu His Phe Trp Ser Ile Asp Gln Thr Glu Phe Arg Ile Pro Pro Arg
1825                1830                1835                1840
Leu Ile Ile Gln Ile Trp Asp Asn Asp Lys Phe Ser Leu Asp Asp Tyr
                1845                1850                1855    
Leu Gly Phe Leu Glu Leu Asp Leu Arg His Thr Ile Ile Pro Ala Lys
            1860                1865                1870        
Ser Pro Glu Lys Cys Arg Leu Asp Met Ile Pro Asp Leu Lys Ala Met
        1875                1880                1885            
Asn Pro Leu Lys Ala Lys Thr Ala Ser Leu Phe Glu Gln Lys Ser Met
    1890                1895                1900                
Lys Gly Trp Trp Pro Cys Tyr Ala Glu Lys Asp Gly Ala Arg Val Met
1905                1910                1915                1920
Ala Gly Lys Val Glu Met Thr Leu Glu Ile Leu Asn Glu Lys Glu Ala
                1925                1930                1935    
Asp Glu Arg Pro Ala Gly Lys Gly Arg Asp Glu Pro Asn Met Asn Pro
            1940                1945                1950        
Lys Leu Asp Leu Pro Asn Arg Pro Glu Thr Ser Phe Leu Trp Phe Thr
        1955                1960                1965            
Asn Pro Cys Lys Thr Met Lys Phe Ile Val Trp Arg Arg Phe Lys Trp
    1970                1975                1980                
Val Ile Ile Gly Leu Leu Phe Leu Leu Ile Leu Leu Leu Phe Val Ala
1985                1990                1995                2000
Val Leu Leu Tyr Ser Leu Pro Asn Tyr Leu Ser Met Lys Ile Val Lys
                2005                2010                2015    
Pro Asn Val
            


<210> 9224
<211> 2061
<212> PRT
<213> Homo sapiens

<400> 9224
Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys
 1               5                  10                  15      
Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys
            20                  25                  30          
Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu
        35                  40                  45              
Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser
    50                  55                  60                  
Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu
65                  70                  75                  80  
Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser
                85                  90                  95      
Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln
            100                 105                 110         
Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser
        115                 120                 125             
Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly
    130                 135                 140                 
Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala
145                 150                 155                 160 
Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala
                165                 170                 175     
Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu
            180                 185                 190         
Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly
        195                 200                 205             
Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val
    210                 215                 220                 
Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe
225                 230                 235                 240 
Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu
                245                 250                 255     
Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg
            260                 265                 270         
Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr
        275                 280                 285             
Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp
    290                 295                 300                 
Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met
305                 310                 315                 320 
Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg
                325                 330                 335     
Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly
            340                 345                 350         
Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu
        355                 360                 365             
Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile
    370                 375                 380                 
Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu
385                 390                 395                 400 
Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn
                405                 410                 415     
Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro
            420                 425                 430         
Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu
        435                 440                 445             
Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile
    450                 455                 460                 
Ala Ala Ser Gly Gly Glu Val Glu Asp Phe Ser Ser Ser Gly Thr Gly
465                 470                 475                 480 
Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu Thr Glu Val Gly Phe Val
                485                 490                 495     
Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser Pro Arg Glu
            500                 505                 510         
Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr Gly Lys Gly
        515                 520                 525             
Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu Ala Thr Phe
    530                 535                 540                 
Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile Ser Asn Asp
545                 550                 555                 560 
Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys Tyr Ser Leu
                565                 570                 575     
Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val Gly Glu Ala
            580                 585                 590         
Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp Thr
        595                 600                 605             
Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val Phe
    610                 615                 620                 
Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr Lys Pro Val
625                 630                 635                 640 
Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg Leu Asp Ala
                645                 650                 655     
Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr Asn Ile Glu
            660                 665                 670         
Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn Gln Leu Ala
        675                 680                 685             
Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp Thr Arg Tyr
    690                 695                 700                 
Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val Leu Asp Thr
705                 710                 715                 720 
Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile His Glu Ala
                725                 730                 735     
Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser Thr Leu Ala
            740                 745                 750         
Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr Glu Glu Pro
        755                 760                 765             
Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg Gly Glu Lys
    770                 775                 780                 
Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu Tyr Ser Thr
785                 790                 795                 800 
Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr Gln Thr Ile
                805                 810                 815     
Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys Val Pro Val
            820                 825                 830         
Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val Glu Lys Lys
        835                 840                 845             
Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala Glu Met Tyr
    850                 855                 860                 
Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser Gly Leu Val
865                 870                 875                 880 
Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu Lys Arg
                885                 890                 895     
Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly Glu Trp Ile
            900                 905                 910         
Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala Gly His Thr
        915                 920                 925             
Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr Pro Gly Gly
    930                 935                 940                 
Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn Gly Asp Lys
945                 950                 955                 960 
Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp Glu Trp Glu
                965                 970                 975     
Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp Glu Lys Gly
            980                 985                 990         
Trp Glu Tyr Gly Ile Thr Ile Pro Pro Asp His Lys Pro Lys Ser Trp
        995                 1000                1005            
Val Ala Ala Glu Lys Met Tyr His Thr His Arg Arg Arg Arg Leu Val
    1010                1015                1020                
Arg Lys Arg Lys Lys Asp Leu Thr Gln Thr Ala Ser Ser Thr Ala Arg
1025                1030                1035                1040
Ala Met Glu Glu Leu Gln Asp Gln Glu Gly Trp Glu Tyr Ala Ser Leu
                1045                1050                1055    
Ile Gly Trp Lys Phe His Trp Lys Gln Arg Ser Ser Asp Thr Phe Arg
            1060                1065                1070        
Arg Arg Arg Trp Arg Arg Lys Met Ala Pro Ser Glu Thr His Gly Ala
        1075                1080                1085            
Ala Ala Ile Phe Lys Leu Glu Gly Ala Leu Gly Ala Asp Thr Thr Glu
    1090                1095                1100                
Asp Gly Asp Glu Lys Ser Leu Glu Lys Gln Lys His Ser Ala Thr Thr
1105                1110                1115                1120
Val Phe Gly Ala Asn Thr Pro Ile Val Ser Cys Asn Phe Asp Arg Val
                1125                1130                1135    
Tyr Ile Tyr His Leu Arg Cys Tyr Val Tyr Gln Ala Arg Asn Leu Leu
            1140                1145                1150        
Ala Leu Asp Lys Asp Ser Phe Ser Asp Pro Tyr Ala His Ile Cys Phe
        1155                1160                1165            
Leu His Arg Ser Lys Thr Thr Glu Ile Ile His Ser Thr Leu Asn Pro
    1170                1175                1180                
Thr Trp Asp Gln Thr Ile Ile Phe Asp Glu Val Glu Ile Tyr Gly Glu
1185                1190                1195                1200
Pro Gln Thr Val Leu Gln Asn Pro Pro Lys Val Ile Met Glu Leu Phe
                1205                1210                1215    
Asp Asn Asp Gln Val Gly Lys Asp Glu Phe Leu Gly Arg Ser Ile Phe
            1220                1225                1230        
Ser Pro Val Val Lys Leu Asn Ser Glu Met Asp Ile Thr Pro Lys Leu
        1235                1240                1245            
Leu Trp His Pro Val Met Asn Gly Asp Lys Ala Cys Gly Asp Val Leu
    1250                1255                1260                
Val Thr Ala Glu Leu Ile Leu Arg Gly Lys Asp Gly Ser Asn Leu Pro
1265                1270                1275                1280
Ile Leu Pro Pro Gln Arg Ala Pro Asn Leu Tyr Met Val Pro Gln Gly
                1285                1290                1295    
Ile Arg Pro Val Val Gln Leu Thr Ala Ile Glu Ile Leu Ala Trp Gly
            1300                1305                1310        
Leu Arg Asn Met Lys Asn Phe Gln Met Ala Ser Ile Thr Ser Pro Ser
        1315                1320                1325            
Leu Val Val Glu Cys Gly Gly Glu Arg Val Glu Ser Val Val Ile Lys
    1330                1335                1340                
Asn Leu Lys Lys Thr Pro Asn Phe Pro Ser Ser Val Leu Phe Met Lys
1345                1350                1355                1360
Val Phe Leu Pro Lys Glu Glu Leu Tyr Met Pro Pro Leu Val Ile Lys
                1365                1370                1375    
Val Ile Asp His Arg Gln Phe Gly Arg Lys Pro Val Val Gly Gln Cys
            1380                1385                1390        
Thr Ile Glu Arg Leu Asp Arg Phe Arg Cys Asp Pro Tyr Ala Gly Lys
        1395                1400                1405            
Glu Asp Ile Val Pro Gln Leu Lys Ala Ser Leu Leu Ser Ala Pro Pro
    1410                1415                1420                
Cys Arg Asp Ile Val Ile Glu Met Glu Asp Thr Lys Pro Leu Leu Ala
1425                1430                1435                1440
Ser Lys Leu Thr Glu Lys Glu Glu Glu Ile Val Asp Trp Trp Ser Lys
                1445                1450                1455    
Phe Tyr Ala Ser Ser Gly Glu His Glu Lys Cys Gly Gln Tyr Ile Gln
            1460                1465                1470        
Lys Gly Tyr Ser Lys Leu Lys Ile Tyr Asn Cys Glu Leu Glu Asn Val
        1475                1480                1485            
Ala Glu Phe Glu Gly Leu Thr Asp Phe Ser Asp Thr Phe Lys Leu Tyr
    1490                1495                1500                
Arg Gly Lys Ser Asp Glu Asn Glu Asp Pro Ser Val Val Gly Glu Phe
1505                1510                1515                1520
Lys Gly Ser Phe Arg Ile Tyr Pro Leu Pro Asp Asp Pro Ser Val Pro
                1525                1530                1535    
Ala Pro Pro Arg Gln Phe Arg Glu Leu Pro Asp Ser Val Pro Gln Glu
            1540                1545                1550        
Cys Thr Val Arg Ile Tyr Ile Val Arg Gly Leu Glu Leu Gln Pro Gln
        1555                1560                1565            
Asp Asn Asn Gly Leu Cys Asp Pro Tyr Ile Lys Ile Thr Leu Gly Lys
    1570                1575                1580                
Lys Val Ile Glu Asp Arg Asp His Tyr Ile Pro Asn Thr Leu Asn Pro
1585                1590                1595                1600
Val Phe Gly Arg Met Tyr Glu Leu Ser Cys Tyr Leu Pro Gln Glu Lys
                1605                1610                1615    
Asp Leu Lys Ile Ser Val Tyr Asp Tyr Asp Thr Phe Thr Arg Asp Glu
            1620                1625                1630        
Lys Val Gly Glu Thr Ile Ile Asp Leu Glu Asn Arg Phe Leu Ser Arg
        1635                1640                1645            
Phe Gly Ser His Cys Gly Ile Pro Glu Glu Tyr Cys Val Ser Gly Val
    1650                1655                1660                
Asn Thr Trp Arg Asp Gln Leu Arg Pro Thr Gln Leu Leu Gln Asn Val
1665                1670                1675                1680
Ala Arg Phe Lys Gly Phe Pro Gln Pro Ile Leu Ser Glu Asp Gly Ser
                1685                1690                1695    
Arg Ile Arg Tyr Gly Gly Arg Asp Tyr Ser Leu Asp Glu Phe Glu Ala
            1700                1705                1710        
Asn Lys Ile Leu His Gln His Leu Gly Ala Pro Glu Glu Arg Leu Ala
        1715                1720                1725            
Leu His Ile Leu Arg Thr Gln Gly Leu Val Pro Glu His Val Glu Thr
    1730                1735                1740                
Arg Thr Leu His Ser Thr Phe Gln Pro Asn Ile Ser Gln Gly Lys Leu
1745                1750                1755                1760
Gln Met Trp Val Asp Val Phe Pro Lys Ser Leu Gly Pro Pro Gly Pro
                1765                1770                1775    
Pro Phe Asn Ile Thr Pro Arg Lys Ala Lys Lys Tyr Tyr Leu Arg Val
            1780                1785                1790        
Ile Ile Trp Asn Thr Lys Asp Val Ile Leu Asp Glu Lys Ser Ile Thr
        1795                1800                1805            
Gly Glu Glu Met Ser Asp Ile Tyr Val Lys Gly Trp Ile Pro Gly Asn
    1810                1815                1820                
Glu Glu Asn Lys Gln Lys Thr Asp Val His Tyr Arg Ser Leu Asp Gly
1825                1830                1835                1840
Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Pro Phe Asp Tyr Leu Pro
                1845                1850                1855    
Ala Glu Gln Leu Cys Ile Val Ala Lys Lys Glu His Phe Trp Ser Ile
            1860                1865                1870        
Asp Gln Thr Glu Phe Arg Ile Pro Pro Arg Leu Ile Ile Gln Ile Trp
        1875                1880                1885            
Asp Asn Asp Lys Phe Ser Leu Asp Asp Tyr Leu Gly Phe Leu Glu Leu
    1890                1895                1900                
Asp Leu Arg His Thr Ile Ile Pro Ala Lys Ser Pro Glu Lys Cys Arg
1905                1910                1915                1920
Leu Asp Met Ile Pro Asp Leu Lys Ala Met Asn Pro Leu Lys Ala Lys
                1925                1930                1935    
Thr Ala Ser Leu Phe Glu Gln Lys Ser Met Lys Gly Trp Trp Pro Cys
            1940                1945                1950        
Tyr Ala Glu Lys Asp Gly Ala Arg Val Met Ala Gly Lys Val Glu Met
        1955                1960                1965            
Thr Leu Glu Ile Leu Asn Glu Lys Glu Ala Asp Glu Arg Pro Ala Gly
    1970                1975                1980                
Lys Gly Arg Asp Glu Pro Asn Met Asn Pro Lys Leu Asp Leu Pro Asn
1985                1990                1995                2000
Arg Pro Glu Thr Ser Phe Leu Trp Phe Thr Asn Pro Cys Lys Thr Met
                2005                2010                2015    
Lys Phe Ile Val Trp Arg Arg Phe Lys Trp Val Ile Ile Gly Leu Leu
            2020                2025                2030        
Phe Leu Leu Ile Leu Leu Leu Phe Val Ala Val Leu Leu Tyr Ser Leu
        2035                2040                2045            
Pro Asn Tyr Leu Ser Met Lys Ile Val Lys Pro Asn Val
    2050                2055                2060    


<210> 9225
<211> 706
<212> PRT
<213> Homo sapiens

<400> 9225
Met Glu Glu Asn Pro Thr Leu Glu Ser Glu Ala Trp Gly Ser Ser Arg
 1               5                  10                  15      
Gly Trp Leu Ala Pro Arg Glu Ala Arg Gly Gly Pro Ser Leu Ser Ser
            20                  25                  30          
Val Leu Asn Glu Leu Pro Ser Ala Ala Thr Leu Arg Tyr Arg Asp Pro
        35                  40                  45              
Gly Val Leu Pro Trp Gly Ala Leu Glu Glu Glu Glu Glu Asp Gly Gly
    50                  55                  60                  
Arg Ser Arg Lys Ala Phe Thr Glu Val Thr Gln Thr Glu Leu Gln Asp
65                  70                  75                  80  
Pro His Pro Ser Arg Glu Leu Pro Trp Pro Met Gln Ala Arg Arg Ala
                85                  90                  95      
His Arg Gln Arg Asn Ala Ser Arg Asp Gln Val Val Tyr Gly Ser Gly
            100                 105                 110         
Thr Lys Thr Asp Arg Trp Ala Arg Leu Leu Arg Arg Ser Lys Glu Lys
        115                 120                 125             
Thr Lys Glu Gly Leu Arg Ser Leu Gln Pro Trp Ala Trp Thr Leu Lys
    130                 135                 140                 
Arg Ile Gly Gly Gln Phe Gly Ala Gly Thr Glu Ser Tyr Phe Ser Leu
145                 150                 155                 160 
Leu Arg Phe Leu Leu Leu Leu Asn Val Leu Ala Ser Val Leu Met Ala
                165                 170                 175     
Cys Met Thr Leu Leu Pro Thr Trp Leu Gly Gly Ala Pro Pro Gly Pro
            180                 185                 190         
Pro Gly Pro Asp Ile Ser Ser Pro Cys Gly Ser Tyr Asn Pro His Ser
        195                 200                 205             
Gln Gly Leu Val Thr Phe Ala Thr Gln Leu Phe Asn Leu Leu Ser Gly
    210                 215                 220                 
Glu Gly Tyr Leu Glu Trp Ser Pro Leu Phe Tyr Gly Phe Tyr Pro Pro
225                 230                 235                 240 
Arg Pro Arg Leu Ala Val Thr Tyr Leu Cys Trp Ala Phe Ala Val Gly
                245                 250                 255     
Leu Ile Cys Leu Leu Leu Ile Leu His Arg Ser Val Ser Gly Leu Lys
            260                 265                 270         
Gln Thr Leu Leu Ala Glu Ser Glu Ala Leu Thr Ser Tyr Ser His Arg
        275                 280                 285             
Val Phe Ser Ala Trp Asp Phe Gly Leu Cys Gly Asp Val His Val Arg
    290                 295                 300                 
Leu Arg Gln Arg Ile Ile Leu Tyr Glu Leu Lys Val Glu Leu Glu Glu
305                 310                 315                 320 
Thr Val Val Arg Arg Gln Ala Ala Val Arg Thr Leu Gly Gln Gln Ala
                325                 330                 335     
Arg Val Trp Leu Val Arg Val Leu Leu Asn Leu Leu Val Val Ala Leu
            340                 345                 350         
Leu Gly Ala Ala Phe Tyr Gly Val Tyr Trp Ala Thr Gly Cys Thr Val
        355                 360                 365             
Glu Leu Gln Glu Met Pro Leu Val Gln Glu Leu Pro Leu Leu Lys Leu
    370                 375                 380                 
Gly Val Asn Tyr Leu Pro Ser Ile Phe Ile Ala Gly Val Asn Phe Val
385                 390                 395                 400 
Leu Pro Pro Val Phe Lys Leu Ile Ala Pro Leu Glu Gly Tyr Thr Arg
                405                 410                 415     
Ser Arg Gln Ile Val Phe Ile Leu Leu Arg Thr Val Phe Leu Arg Leu
            420                 425                 430         
Ala Ser Leu Val Val Leu Leu Phe Ser Leu Trp Asn Gln Ile Thr Cys
        435                 440                 445             
Gly Gly Asp Ser Glu Ala Glu Asp Cys Lys Thr Cys Gly Tyr Asn Tyr
    450                 455                 460                 
Lys Gln Leu Pro Cys Trp Glu Thr Val Leu Gly Gln Glu Met Tyr Lys
465                 470                 475                 480 
Leu Leu Leu Phe Asp Leu Leu Thr Val Leu Ala Val Ala Leu Leu Ile
                485                 490                 495     
Gln Phe Pro Arg Lys Leu Leu Cys Gly Leu Cys Pro Gly Ala Leu Gly
            500                 505                 510         
Arg Leu Ala Gly Thr Gln Glu Phe Gln Val Pro Asp Glu Val Leu Gly
        515                 520                 525             
Leu Ile Tyr Ala Gln Thr Val Val Trp Val Gly Ser Phe Phe Cys Pro
    530                 535                 540                 
Leu Leu Pro Leu Leu Asn Thr Val Lys Phe Leu Leu Leu Phe Tyr Leu
545                 550                 555                 560 
Lys Lys Leu Thr Leu Phe Ser Thr Cys Ser Pro Ala Ala Arg Thr Phe
                565                 570                 575     
Arg Ala Ser Ala Ala Asn Phe Phe Phe Pro Leu Val Leu Leu Leu Gly
            580                 585                 590         
Leu Ala Ile Ser Ser Val Pro Leu Leu Tyr Ser Ile Phe Leu Ile Pro
        595                 600                 605             
Pro Ser Lys Leu Cys Gly Pro Phe Arg Gly Gln Ser Ser Ile Trp Ala
    610                 615                 620                 
Gln Ile Pro Glu Ser Ile Ser Ser Leu Pro Glu Thr Thr Gln Asn Phe
625                 630                 635                 640 
Leu Phe Phe Leu Gly Thr Gln Ala Phe Ala Val Pro Leu Leu Leu Ile
                645                 650                 655     
Ser Ser Ile Leu Met Ala Tyr Thr Val Ala Leu Ala Asn Ser Tyr Gly
            660                 665                 670         
Arg Leu Ile Ser Glu Leu Lys Arg Gln Arg Gln Thr Glu Ala Gln Asn
        675                 680                 685             
Lys Val Phe Leu Ala Arg Arg Ala Val Ala Leu Thr Ser Thr Lys Pro
    690                 695                 700                 
Ala Leu
705     


<210> 9226
<211> 647
<212> PRT
<213> Homo sapiens

<400> 9226
Met Ser Glu Ser Arg Arg Arg Gly Arg Gly Arg Gly Lys Lys His Pro
 1               5                  10                  15      
Glu Gly Arg Lys Arg Glu Arg Glu Pro Asp Pro Gly Glu Lys Ala Thr
            20                  25                  30          
Arg Pro Lys Leu Lys Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu
        35                  40                  45              
Lys Gln Ser Leu Lys Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser
    50                  55                  60                  
Tyr Arg Trp Phe Lys Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile
65                  70                  75                  80  
Arg Ile Lys Tyr Gly Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn
                85                  90                  95      
Lys Val Lys Val Glu Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn
            100                 105                 110         
Ile Leu Gly Lys Asp Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val
        115                 120                 125             
Ser Thr Thr Leu Ser Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu
    130                 135                 140                 
Thr Ala Lys Ser Tyr Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu
145                 150                 155                 160 
Gly Ile Asn Gln Leu Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln
                165                 170                 175     
Arg Cys Leu Glu Lys Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys
            180                 185                 190         
Gln Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly
        195                 200                 205             
Ile Cys Val Ala Leu Leu Val Val Gly Ile Val Cys Val Val Ala Tyr
    210                 215                 220                 
Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His Asn His Leu Arg Gln
225                 230                 235                 240 
Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser
                245                 250                 255     
His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser
            260                 265                 270         
Lys Asn Val Pro Ala Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr
        275                 280                 285             
Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser His His Cys Ser Thr
    290                 295                 300                 
Ala Thr Pro Thr Ser Ser His Arg His Glu Ser His Thr Trp Ser Leu
305                 310                 315                 320 
Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu
                325                 330                 335     
Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala
            340                 345                 350         
Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala
        355                 360                 365             
Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro
    370                 375                 380                 
His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser
385                 390                 395                 400 
Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu
                405                 410                 415     
Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala
            420                 425                 430         
Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro
        435                 440                 445             
Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly
    450                 455                 460                 
Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly
465                 470                 475                 480 
Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser
                485                 490                 495     
Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr
            500                 505                 510         
Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly
        515                 520                 525             
Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg
    530                 535                 540                 
Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu
545                 550                 555                 560 
Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp
                565                 570                 575     
Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe
            580                 585                 590         
Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro
        595                 600                 605             
Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His
    610                 615                 620                 
Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala
625                 630                 635                 640 
Lys Gln Asp Ser Ala Pro Leu
                645         


<210> 9227
<211> 617
<212> PRT
<213> Homo sapiens

<400> 9227
Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys Cys
 1               5                  10                  15      
Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys Asp
            20                  25                  30          
Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly Asn
        35                  40                  45              
Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu Asp
    50                  55                  60                  
Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp Thr
65                  70                  75                  80  
Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser Ser
                85                  90                  95      
Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr Cys
            100                 105                 110         
Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu Ser
        115                 120                 125             
Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys Leu
    130                 135                 140                 
Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys His Leu Gly Phe
145                 150                 155                 160 
Glu Leu Lys Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile
                165                 170                 175     
Thr Gly Ile Cys Val Ala Leu Leu Val Val Gly Ile Val Cys Val Val
            180                 185                 190         
Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His Asn His Leu
        195                 200                 205             
Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu Ala Asn Gly
    210                 215                 220                 
Pro Ser His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met Ala Asp Tyr
225                 230                 235                 240 
Ile Ser Lys Asn Val Pro Ala Thr Asp His Val Ile Arg Arg Glu Thr
                245                 250                 255     
Glu Thr Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser His His Cys
            260                 265                 270         
Ser Thr Ala Thr Pro Thr Ser Ser His Arg His Glu Ser His Thr Trp
        275                 280                 285             
Ser Leu Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly Ile
    290                 295                 300                 
Met Leu Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys Val
305                 310                 315                 320 
Glu Ala Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg Arg
                325                 330                 335     
Arg Ala Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser Leu Arg Asp
            340                 345                 350         
Ser Pro His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala Arg
        355                 360                 365             
Leu Ser Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln Val Pro Thr
    370                 375                 380                 
Phe Glu Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser Leu Pro Pro
385                 390                 395                 400 
Ala Ala Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu Arg
                405                 410                 415     
His Pro Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly
            420                 425                 430         
Pro Gly Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala
        435                 440                 445             
Ala Gly Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser Leu
    450                 455                 460                 
Gly Ser Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu Tyr
465                 470                 475                 480 
Glu Thr Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg Ala
                485                 490                 495     
Arg Gly Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg Arg
            500                 505                 510         
Ser Arg Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg Asp
        515                 520                 525             
Ser Leu Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala Ser
    530                 535                 540                 
Asp Asp Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser Thr
545                 550                 555                 560 
Pro Phe Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg Ser Asp Ser
                565                 570                 575     
Pro Pro Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu Asp
            580                 585                 590         
Ser His Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly Pro Pro Pro
        595                 600                 605             
Arg Ala Lys Gln Asp Ser Ala Pro Leu
    610                 615         


<210> 9228
<211> 1624
<212> PRT
<213> Homo sapiens

<400> 9228
Met Ser Lys Arg Arg Met Ser Val Gly Gln Gln Thr Trp Ala Leu Leu
 1               5                  10                  15      
Cys Lys Asn Cys Leu Lys Lys Trp Arg Met Lys Arg Gln Thr Leu Leu
            20                  25                  30          
Glu Trp Leu Phe Ser Phe Leu Leu Val Leu Phe Leu Tyr Leu Phe Phe
        35                  40                  45              
Ser Asn Leu His Gln Val His Asp Thr Pro Gln Met Ser Ser Met Asp
    50                  55                  60                  
Leu Gly Arg Val Asp Ser Phe Asn Asp Thr Asn Tyr Val Ile Ala Phe
65                  70                  75                  80  
Ala Pro Glu Ser Lys Thr Thr Gln Glu Ile Met Asn Lys Val Ala Ser
                85                  90                  95      
Ala Pro Phe Leu Lys Gly Arg Thr Ile Met Gly Trp Pro Asp Glu Lys
            100                 105                 110         
Ser Met Asp Glu Leu Asp Leu Asn Tyr Ser Ile Asp Ala Val Arg Val
        115                 120                 125             
Ile Phe Thr Asp Thr Phe Ser Tyr His Leu Lys Phe Ser Trp Gly His
    130                 135                 140                 
Arg Ile Pro Met Met Lys Glu His Arg Asp His Ser Ala His Cys Gln
145                 150                 155                 160 
Ala Val Asn Glu Lys Met Lys Cys Glu Gly Ser Glu Phe Trp Glu Lys
                165                 170                 175     
Gly Phe Val Ala Phe Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Ile
            180                 185                 190         
Ala Thr Asn His Ser Val Met Glu Gln Leu Met Ser Val Thr Gly Val
        195                 200                 205             
His Met Lys Ile Leu Pro Phe Val Ala Gln Gly Gly Val Ala Thr Asp
    210                 215                 220                 
Phe Phe Ile Phe Phe Cys Ile Ile Ser Phe Ser Thr Phe Ile Tyr Tyr
225                 230                 235                 240 
Val Ser Val Asn Val Thr Gln Glu Arg Gln Tyr Ile Thr Ser Leu Met
                245                 250                 255     
Thr Met Met Gly Leu Arg Glu Ser Ala Phe Trp Leu Ser Trp Gly Leu
            260                 265                 270         
Met Tyr Ala Gly Phe Ile Leu Ile Met Ala Thr Leu Met Ala Leu Ile
        275                 280                 285             
Val Lys Ser Ala Gln Ile Val Val Leu Thr Gly Phe Val Met Val Phe
    290                 295                 300                 
Thr Leu Phe Leu Leu Tyr Gly Leu Ser Leu Ile Thr Leu Ala Phe Leu
305                 310                 315                 320 
Met Ser Val Leu Ile Lys Lys Pro Phe Leu Thr Gly Leu Val Val Phe
                325                 330                 335     
Leu Leu Ile Val Phe Trp Gly Ile Leu Gly Phe Pro Ala Leu Tyr Thr
            340                 345                 350         
Arg Leu Pro Ala Phe Leu Glu Trp Thr Leu Cys Leu Leu Ser Pro Phe
        355                 360                 365             
Ala Phe Thr Val Gly Met Ala Gln Leu Ile His Leu Asp Tyr Asp Val
    370                 375                 380                 
Asn Ser Asn Ala His Leu Asp Ser Ser Gln Asn Pro Tyr Leu Ile Ile
385                 390                 395                 400 
Ala Thr Leu Phe Met Leu Val Phe Asp Thr Leu Leu Tyr Leu Val Leu
                405                 410                 415     
Thr Leu Tyr Phe Asp Lys Ile Leu Pro Ala Glu Tyr Gly His Arg Cys
            420                 425                 430         
Ser Pro Leu Phe Phe Leu Lys Ser Cys Phe Trp Phe Gln His Gly Arg
        435                 440                 445             
Ala Asn His Val Val Leu Glu Asn Glu Thr Asp Ser Asp Pro Thr Pro
    450                 455                 460                 
Asn Asp Cys Phe Glu Pro Val Ser Pro Glu Phe Cys Gly Lys Glu Ala
465                 470                 475                 480 
Ile Arg Ile Lys Asn Leu Lys Lys Glu Tyr Ala Gly Lys Cys Glu Arg
                485                 490                 495     
Val Glu Ala Leu Lys Gly Val Val Phe Asp Ile Tyr Glu Gly Gln Ile
            500                 505                 510         
Thr Ala Leu Leu Gly His Ser Gly Ala Gly Lys Thr Thr Leu Leu Asn
        515                 520                 525             
Ile Leu Ser Gly Leu Ser Val Pro Thr Ser Gly Ser Val Thr Val Tyr
    530                 535                 540                 
Asn His Thr Leu Ser Arg Met Ala Asp Ile Glu Asn Ile Ser Lys Phe
545                 550                 555                 560 
Thr Gly Phe Cys Pro Gln Ser Asn Val Gln Phe Gly Phe Leu Thr Val
                565                 570                 575     
Lys Glu Asn Leu Arg Leu Phe Ala Lys Ile Lys Gly Ile Leu Pro His
            580                 585                 590         
Glu Val Glu Lys Glu Val Gln Arg Val Val Gln Glu Leu Glu Met Glu
        595                 600                 605             
Asn Ile Gln Asp Ile Leu Ala Gln Asn Leu Ser Gly Gly Gln Asn Arg
    610                 615                 620                 
Lys Leu Thr Phe Gly Ile Ala Ile Leu Gly Asp Pro Gln Val Leu Leu
625                 630                 635                 640 
Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Leu Ser Arg His Arg Ile
                645                 650                 655     
Trp Asn Leu Leu Lys Glu Gly Lys Ser Asp Arg Val Ile Leu Phe Ser
            660                 665                 670         
Thr Gln Phe Ile Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Phe
        675                 680                 685             
Ile Ser Asn Gly Lys Leu Lys Cys Ala Gly Ser Ser Leu Phe Leu Lys
    690                 695                 700                 
Lys Lys Trp Gly Ile Gly Tyr His Leu Ser Leu His Leu Asn Glu Arg
705                 710                 715                 720 
Cys Asp Pro Glu Ser Ile Thr Ser Leu Val Lys Gln His Ile Ser Asp
                725                 730                 735     
Ala Lys Leu Thr Ala Gln Ser Glu Glu Lys Leu Val Tyr Ile Leu Pro
            740                 745                 750         
Leu Glu Arg Thr Asn Lys Phe Pro Glu Leu Tyr Arg Asp Leu Asp Arg
        755                 760                 765             
Cys Ser Asn Gln Gly Ile Glu Asp Tyr Gly Val Ser Ile Thr Thr Leu
    770                 775                 780                 
Asn Glu Val Phe Leu Lys Leu Glu Gly Lys Ser Thr Ile Asp Glu Ser
785                 790                 795                 800 
Asp Ile Gly Ile Trp Gly Gln Leu Gln Thr Asp Gly Ala Lys Asp Ile
                805                 810                 815     
Gly Ser Leu Val Glu Leu Glu Gln Val Leu Ser Ser Phe His Glu Thr
            820                 825                 830         
Arg Lys Thr Ile Ser Gly Val Ala Leu Trp Arg Gln Gln Val Cys Ala
        835                 840                 845             
Ile Ala Lys Val Arg Phe Leu Lys Leu Lys Lys Glu Arg Lys Ser Leu
    850                 855                 860                 
Trp Thr Ile Leu Leu Leu Phe Gly Ile Ser Phe Ile Pro Gln Leu Leu
865                 870                 875                 880 
Glu His Leu Phe Tyr Glu Ser Tyr Gln Lys Ser Tyr Pro Trp Glu Leu
                885                 890                 895     
Ser Pro Asn Thr Tyr Phe Leu Ser Pro Gly Gln Gln Pro Gln Asp Pro
            900                 905                 910         
Leu Thr His Leu Leu Val Ile Asn Lys Thr Gly Ser Thr Ile Asp Asn
        915                 920                 925             
Phe Leu His Ser Leu Arg Arg Gln Asn Ile Ala Ile Glu Val Asp Ala
    930                 935                 940                 
Phe Gly Thr Arg Asn Gly Thr Asp Asp Pro Ser Tyr Asn Gly Ala Ile
945                 950                 955                 960 
Ile Val Ser Gly Asp Glu Lys Asp His Arg Phe Ser Ile Ala Cys Asn
                965                 970                 975     
Thr Lys Arg Leu Asn Cys Phe Pro Val Leu Leu Asp Val Ile Ser Asn
            980                 985                 990         
Gly Leu Leu Gly Ile Phe Asn Ser Ser Glu His Ile Gln Thr Asp Arg
        995                 1000                1005            
Ser Thr Phe Phe Glu Glu His Met Asp Tyr Glu Tyr Gly Tyr Arg Ser
    1010                1015                1020                
Asn Thr Phe Phe Trp Ile Pro Met Ala Ala Ser Phe Thr Pro Tyr Ile
1025                1030                1035                1040
Ala Met Ser Ser Ile Gly Asp Tyr Lys Lys Lys Ala His Ser Gln Leu
                1045                1050                1055    
Arg Ile Ser Gly Leu Tyr Pro Ser Ala Tyr Trp Phe Gly Gln Ala Leu
            1060                1065                1070        
Val Asp Val Ser Leu Tyr Phe Leu Ile Leu Leu Leu Met Gln Ile Met
        1075                1080                1085            
Asp Tyr Ile Phe Ser Pro Glu Glu Ile Ile Phe Ile Ile Gln Asn Leu
    1090                1095                1100                
Leu Ile Gln Ile Leu Cys Ser Ile Gly Tyr Val Ser Ser Leu Val Phe
1105                1110                1115                1120
Leu Thr Tyr Val Ile Ser Phe Ile Phe Arg Asn Gly Arg Lys Asn Ser
                1125                1130                1135    
Gly Ile Trp Ser Phe Phe Phe Leu Ile Val Val Ile Phe Ser Ile Val
            1140                1145                1150        
Ala Thr Asp Leu Asn Glu Tyr Gly Phe Leu Gly Leu Phe Phe Gly Thr
        1155                1160                1165            
Met Leu Ile Pro Pro Phe Thr Leu Ile Gly Ser Leu Phe Ile Phe Ser
    1170                1175                1180                
Glu Ile Ser Pro Asp Ser Met Asp Tyr Leu Gly Ala Ser Glu Ser Glu
1185                1190                1195                1200
Ile Val Tyr Leu Ala Leu Leu Ile Pro Tyr Leu His Phe Leu Ile Phe
                1205                1210                1215    
Leu Phe Ile Leu Arg Cys Leu Glu Met Asn Cys Arg Lys Lys Leu Met
            1220                1225                1230        
Arg Lys Asp Pro Val Phe Arg Ile Ser Pro Arg Ser Asn Ala Ile Phe
        1235                1240                1245            
Pro Asn Pro Glu Glu Pro Glu Gly Glu Glu Glu Asp Ile Gln Met Glu
    1250                1255                1260                
Arg Met Arg Thr Val Asn Ala Met Ala Val Arg Asp Phe Asp Glu Thr
1265                1270                1275                1280
Pro Val Ile Ile Ala Ser Cys Leu Arg Lys Glu Tyr Ala Gly Lys Lys
                1285                1290                1295    
Lys Asn Cys Phe Ser Lys Arg Lys Lys Lys Ile Ala Thr Arg Asn Val
            1300                1305                1310        
Ser Phe Cys Val Lys Lys Gly Glu Val Ile Gly Leu Leu Gly His Asn
        1315                1320                1325            
Gly Ala Gly Lys Ser Thr Thr Ile Lys Met Ile Thr Gly Asp Thr Lys
    1330                1335                1340                
Pro Thr Ala Gly Gln Val Ile Leu Lys Gly Ser Gly Gly Gly Glu Pro
1345                1350                1355                1360
Leu Gly Phe Leu Gly Tyr Cys Pro Gln Glu Asn Ala Leu Trp Pro Asn
                1365                1370                1375    
Leu Thr Val Arg Gln His Leu Glu Val Tyr Ala Ala Val Lys Gly Leu
            1380                1385                1390        
Arg Lys Gly Asp Ala Met Ile Ala Ile Thr Arg Leu Val Asp Ala Leu
        1395                1400                1405            
Lys Leu Gln Asp Gln Leu Lys Ala Pro Val Lys Thr Leu Ser Glu Gly
    1410                1415                1420                
Ile Lys Arg Lys Leu Cys Phe Val Leu Ser Ile Leu Gly Asn Pro Ser
1425                1430                1435                1440
Val Val Leu Leu Asp Glu Pro Ser Thr Gly Met Asp Pro Glu Gly Gln
                1445                1450                1455    
Gln Gln Met Trp Gln Val Ile Arg Ala Thr Phe Arg Asn Thr Glu Arg
            1460                1465                1470        
Gly Ala Leu Leu Thr Thr His Tyr Met Ala Glu Ala Glu Ala Val Cys
        1475                1480                1485            
Asp Arg Val Ala Ile Met Val Ser Gly Arg Leu Arg Cys Ile Gly Ser
    1490                1495                1500                
Ile Gln His Leu Lys Ser Lys Phe Gly Lys Asp Tyr Leu Leu Glu Met
1505                1510                1515                1520
Lys Leu Lys Asn Leu Ala Gln Met Glu Pro Leu His Ala Glu Ile Leu
                1525                1530                1535    
Arg Leu Phe Pro Gln Ala Ala Gln Gln Glu Arg Phe Ser Ser Leu Met
            1540                1545                1550        
Val Tyr Lys Leu Pro Val Glu Asp Val Arg Pro Leu Ser Gln Ala Phe
        1555                1560                1565            
Phe Lys Leu Glu Ile Val Lys Gln Ser Phe Asp Leu Glu Glu Tyr Ser
    1570                1575                1580                
Leu Ser Gln Ser Thr Leu Glu Gln Val Phe Leu Glu Leu Ser Lys Glu
1585                1590                1595                1600
Gln Glu Leu Gly Asp Leu Glu Glu Asp Phe Asp Pro Ser Val Lys Trp
                1605                1610                1615    
Lys Leu Leu Leu Gln Glu Glu Pro
            1620                


<210> 9229
<211> 1435
<212> PRT
<213> Homo sapiens

<400> 9229
Met Ser Lys Arg Arg Met Ser Val Gly Gln Gln Thr Trp Ala Leu Leu
 1               5                  10                  15      
Cys Lys Asn Cys Leu Lys Lys Trp Arg Met Lys Arg Gln Thr Leu Leu
            20                  25                  30          
Glu Trp Leu Phe Ser Phe Leu Leu Val Leu Phe Leu Tyr Leu Phe Phe
        35                  40                  45              
Ser Asn Leu His Gln Val His Asp Thr Pro Gln Met Ser Ser Met Asp
    50                  55                  60                  
Leu Gly Arg Val Asp Ser Phe Asn Asp Thr Asn Tyr Val Ile Ala Phe
65                  70                  75                  80  
Ala Pro Glu Ser Lys Thr Thr Gln Glu Ile Met Asn Lys Val Ala Ser
                85                  90                  95      
Ala Pro Phe Leu Lys Gly Arg Thr Ile Met Gly Trp Pro Asp Glu Lys
            100                 105                 110         
Ser Met Asp Glu Leu Asp Leu Asn Tyr Ser Ile Asp Ala Val Arg Val
        115                 120                 125             
Ile Phe Thr Asp Thr Phe Ser Tyr His Leu Lys Phe Ser Trp Gly His
    130                 135                 140                 
Arg Ile Pro Met Met Lys Glu His Arg Asp His Ser Ala His Cys Gln
145                 150                 155                 160 
Ala Val Asn Glu Lys Met Lys Cys Glu Gly Ser Glu Phe Trp Glu Lys
                165                 170                 175     
Gly Phe Val Ala Phe Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Ile
            180                 185                 190         
Ala Thr Asn His Ser Val Met Glu Gln Leu Met Ser Val Thr Gly Val
        195                 200                 205             
His Met Lys Ile Leu Pro Phe Val Ala Gln Gly Gly Val Ala Thr Asp
    210                 215                 220                 
Phe Phe Ile Phe Phe Cys Ile Ile Ser Phe Ser Thr Phe Ile Tyr Tyr
225                 230                 235                 240 
Val Ser Val Asn Val Thr Gln Glu Arg Gln Tyr Ile Thr Ser Leu Met
                245                 250                 255     
Thr Met Met Gly Leu Arg Glu Ser Ala Phe Trp Leu Ser Trp Gly Leu
            260                 265                 270         
Met Tyr Ala Gly Phe Ile Leu Ile Met Ala Thr Leu Met Ala Leu Ile
        275                 280                 285             
Val Lys Ser Ala Gln Ile Val Val Leu Thr Gly Phe Val Met Val Phe
    290                 295                 300                 
Thr Leu Phe Leu Leu Tyr Gly Leu Ser Leu Ile Thr Leu Ala Phe Leu
305                 310                 315                 320 
Met Ser Val Leu Ile Lys Lys Pro Phe Leu Thr Gly Leu Val Val Phe
                325                 330                 335     
Leu Leu Ile Val Phe Trp Gly Ile Leu Gly Phe Pro Ala Leu Tyr Thr
            340                 345                 350         
Arg Leu Pro Ala Phe Leu Glu Trp Thr Leu Cys Leu Leu Ser Pro Phe
        355                 360                 365             
Ala Phe Thr Val Gly Met Ala Gln Leu Ile His Leu Asp Tyr Asp Val
    370                 375                 380                 
Asn Ser Asn Ala His Leu Asp Ser Ser Gln Asn Pro Tyr Leu Ile Ile
385                 390                 395                 400 
Ala Thr Leu Phe Met Leu Val Phe Asp Thr Leu Leu Tyr Leu Val Leu
                405                 410                 415     
Thr Leu Tyr Phe Asp Lys Ile Leu Pro Ala Glu Tyr Gly His Arg Cys
            420                 425                 430         
Ser Pro Leu Phe Phe Leu Lys Ser Cys Phe Trp Phe Gln His Gly Arg
        435                 440                 445             
Ala Asn His Val Val Leu Glu Asn Glu Thr Asp Ser Asp Pro Thr Pro
    450                 455                 460                 
Asn Asp Cys Phe Glu Pro Val Ser Pro Glu Phe Cys Gly Lys Glu Ala
465                 470                 475                 480 
Ile Arg Ile Lys Asn Leu Lys Lys Glu Tyr Ala Gly Lys Cys Glu Arg
                485                 490                 495     
Val Glu Ala Leu Lys Gly Val Val Phe Asp Ile Tyr Glu Gly Gln Ile
            500                 505                 510         
Thr Ala Leu Leu Gly His Ser Gly Ala Gly Lys Thr Thr Leu Leu Asn
        515                 520                 525             
Ile Leu Ser Gly Leu Ser Val Pro Thr Ser Gly Ser Val Thr Val Tyr
    530                 535                 540                 
Asn His Thr Leu Ser Arg Met Ala Asp Ile Glu Asn Ile Ser Lys Phe
545                 550                 555                 560 
Thr Gly Phe Cys Pro Gln Ser Asn Val Gln Phe Gly Phe Leu Thr Val
                565                 570                 575     
Lys Glu Asn Leu Arg Leu Phe Ala Lys Ile Lys Gly Ile Leu Pro His
            580                 585                 590         
Glu Val Glu Lys Glu Val Gln Arg Val Val Gln Glu Leu Glu Met Glu
        595                 600                 605             
Asn Ile Gln Asp Ile Leu Ala Gln Asn Leu Ser Gly Gly Gln Asn Arg
    610                 615                 620                 
Lys Leu Thr Phe Gly Ile Ala Ile Leu Gly Asp Pro Gln Val Leu Leu
625                 630                 635                 640 
Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Leu Ser Arg His Arg Ile
                645                 650                 655     
Trp Asn Leu Leu Lys Glu Gly Lys Ser Asp Arg Val Ile Leu Phe Ser
            660                 665                 670         
Thr Gln Phe Ile Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Phe
        675                 680                 685             
Ile Ser Asn Gly Lys Leu Lys Cys Ala Gly Ser Ser Leu Phe Leu Lys
    690                 695                 700                 
Lys Lys Trp Gly Ile Gly Tyr His Leu Ser Leu His Leu Asn Glu Arg
705                 710                 715                 720 
Cys Asp Pro Glu Ser Ile Thr Ser Leu Val Lys Gln His Ile Ser Asp
                725                 730                 735     
Ala Lys Leu Thr Ala Gln Ser Glu Glu Lys Leu Val Tyr Ile Leu Pro
            740                 745                 750         
Leu Glu Arg Thr Asn Lys Phe Pro Glu Leu Tyr Arg Asp Leu Asp Arg
        755                 760                 765             
Cys Ser Asn Gln Gly Ile Glu Asp Tyr Gly Val Ser Ile Thr Thr Leu
    770                 775                 780                 
Asn Glu Val Phe Leu Lys Leu Glu Gly Lys Ser Thr Ile Asp Glu Ser
785                 790                 795                 800 
Asp Ile Gly Ile Trp Gly Gln Leu Gln Thr Asp Gly Ala Lys Asp Ile
                805                 810                 815     
Gly Ser Leu Val Glu Leu Glu Gln Val Leu Ser Ser Phe His Glu Thr
            820                 825                 830         
Arg Lys Thr Ile Ser Gly Val Ala Leu Trp Arg Gln Gln Val Cys Ala
        835                 840                 845             
Ile Ala Lys Val Arg Phe Leu Lys Leu Lys Lys Glu Arg Lys Ser Leu
    850                 855                 860                 
Trp Thr Ile Leu Leu Leu Phe Gly Ile Ser Phe Ile Pro Gln Leu Leu
865                 870                 875                 880 
Glu His Leu Phe Tyr Glu Ser Tyr Gln Lys Ser Tyr Pro Trp Glu Leu
                885                 890                 895     
Ser Pro Asn Thr Tyr Phe Leu Ser Pro Gly Gln Gln Pro Gln Asp Pro
            900                 905                 910         
Leu Thr His Leu Leu Val Ile Asn Lys Thr Gly Ser Thr Ile Asp Asn
        915                 920                 925             
Phe Leu His Ser Leu Arg Arg Gln Asn Ile Ala Ile Glu Val Asp Ala
    930                 935                 940                 
Phe Gly Thr Arg Asn Gly Thr Asp Asp Pro Ser Tyr Asn Gly Ala Ile
945                 950                 955                 960 
Ile Val Ser Gly Asp Glu Lys Asp His Arg Phe Ser Ile Ala Cys Asn
                965                 970                 975     
Thr Lys Arg Leu Asn Cys Phe Pro Val Leu Leu Asp Val Ile Ser Asn
            980                 985                 990         
Gly Leu Leu Gly Ile Phe Asn Ser Ser Glu His Ile Gln Thr Asp Arg
        995                 1000                1005            
Ser Thr Phe Phe Glu Glu His Met Asp Tyr Glu Tyr Gly Tyr Arg Ser
    1010                1015                1020                
Asn Thr Phe Phe Trp Ile Pro Met Ala Ala Ser Phe Thr Pro Tyr Ile
1025                1030                1035                1040
Ala Met Ser Ser Ile Gly Asp Tyr Lys Lys Lys Ala His Ser Gln Leu
                1045                1050                1055    
Arg Ile Ser Gly Leu Tyr Pro Ser Ala Tyr Trp Phe Gly Gln Ala Leu
            1060                1065                1070        
Val Asp Val Ser Leu Tyr Phe Leu Ile Leu Leu Leu Met Gln Ile Met
        1075                1080                1085            
Asp Tyr Ile Phe Ser Pro Glu Glu Ile Ile Phe Ile Ile Gln Asn Leu
    1090                1095                1100                
Leu Ile Gln Ile Leu Cys Ser Ile Gly Tyr Val Ser Ser Leu Val Phe
1105                1110                1115                1120
Leu Thr Tyr Val Ile Ser Phe Ile Phe Arg Asn Gly Arg Lys Asn Ser
                1125                1130                1135    
Gly Ile Trp Ser Phe Phe Phe Leu Ile Val Val Ile Phe Ser Ile Val
            1140                1145                1150        
Ala Thr Asp Leu Asn Glu Tyr Gly Phe Leu Gly Leu Phe Phe Gly Thr
        1155                1160                1165            
Met Leu Ile Pro Pro Phe Thr Leu Ile Gly Ser Leu Phe Ile Phe Ser
    1170                1175                1180                
Glu Ile Ser Pro Asp Ser Met Asp Tyr Leu Gly Ala Ser Glu Ser Glu
1185                1190                1195                1200
Ile Val Tyr Leu Ala Leu Leu Ile Pro Tyr Leu His Phe Leu Ile Phe
                1205                1210                1215    
Leu Phe Ile Leu Arg Cys Leu Glu Met Asn Cys Arg Lys Lys Leu Met
            1220                1225                1230        
Arg Lys Asp Pro Val Phe Arg Ile Ser Pro Arg Ser Asn Ala Ile Phe
        1235                1240                1245            
Pro Asn Pro Glu Glu Pro Glu Gly Glu Glu Glu Asp Ile Gln Met Glu
    1250                1255                1260                
Arg Met Arg Thr Val Asn Ala Met Ala Val Arg Asp Phe Asp Glu Thr
1265                1270                1275                1280
Pro Val Ile Ile Ala Ser Cys Leu Arg Lys Glu Tyr Ala Gly Lys Lys
                1285                1290                1295    
Lys Asn Cys Phe Ser Lys Arg Lys Lys Lys Ile Ala Thr Arg Asn Val
            1300                1305                1310        
Ser Phe Cys Val Lys Lys Gly Glu Val Ile Gly Leu Leu Gly His Asn
        1315                1320                1325            
Gly Ala Gly Lys Ser Thr Thr Ile Lys Met Ile Thr Gly Asp Thr Lys
    1330                1335                1340                
Pro Thr Ala Gly Gln Val Ile Leu Lys Gly Ser Gly Gly Gly Glu Pro
1345                1350                1355                1360
Leu Gly Phe Leu Gly Tyr Cys Pro Gln Glu Asn Ala Leu Trp Pro Asn
                1365                1370                1375    
Leu Thr Val Arg Gln His Leu Glu Val Tyr Ala Ala Val Lys Gly Leu
            1380                1385                1390        
Arg Lys Gly Asp Ala Met Ile Ala Ile Thr Arg Leu Val Asp Ala Leu
        1395                1400                1405            
Lys Leu Gln Asp Gln Leu Lys Ala Pro Val Lys Thr Leu Ser Glu Gly
    1410                1415                1420                
Ile Lys Arg Lys Ala Gly Asp Ser Gly His Leu
1425                1430                1435


<210> 9230
<211> 1238
<212> PRT
<213> Homo sapiens

<400> 9230
Met Asp Ala Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp
 1               5                  10                  15      
Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr Pro Cys Phe
            20                  25                  30          
Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu Trp Val Ala
        35                  40                  45              
Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg Gly Tyr Ile
    50                  55                  60                  
Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly Val Leu Leu
65                  70                  75                  80  
Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His Gly Leu Val
                85                  90                  95      
His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro Leu Val Val
            100                 105                 110         
Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr Glu Arg Leu
        115                 120                 125             
Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp Phe Leu Cys
    130                 135                 140                 
Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu Leu Ala Lys
145                 150                 155                 160 
Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr Phe Tyr Ile
                165                 170                 175     
His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys Phe Arg Glu
            180                 185                 190         
Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn Pro Tyr Pro
        195                 200                 205             
Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp Trp Phe Thr
    210                 215                 220                 
Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu Lys Asp Leu
225                 230                 235                 240 
Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val Gln Gln Leu
                245                 250                 255     
Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg His Lys Ala
            260                 265                 270         
Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu Val Leu Leu
        275                 280                 285             
Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys Ala Leu Leu
    290                 295                 300                 
Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe Lys Leu Ile
305                 310                 315                 320 
Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser Ile Leu Ile
                325                 330                 335     
Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly Phe Leu Val
            340                 345                 350         
Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu Ile Leu Gln
        355                 360                 365             
His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe Arg Thr Gly
    370                 375                 380                 
Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Val
385                 390                 395                 400 
Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp
                405                 410                 415     
Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu Leu Trp Ser
            420                 425                 430         
Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp Gln Asn Leu
        435                 440                 445             
Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu Leu Ile Pro
    450                 455                 460                 
Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln Val Lys Gln
465                 470                 475                 480 
Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu Ile Leu Asn
                485                 490                 495     
Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser Phe Leu Lys
            500                 505                 510         
Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu Arg Thr Ala
        515                 520                 525             
Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys Ser Pro Phe
    530                 535                 540                 
Leu Val Thr Leu Ile Thr Leu Trp Val Tyr Val Tyr Val Asp Pro Asn
545                 550                 555                 560 
Asn Val Leu Asp Ala Glu Lys Ala Phe Val Ser Val Ser Leu Phe Asn
                565                 570                 575     
Ile Leu Arg Leu Pro Leu Asn Met Leu Pro Gln Leu Ile Ser Asn Leu
            580                 585                 590         
Thr Gln Ala Ser Val Ser Leu Lys Arg Ile Gln Gln Phe Leu Ser Gln
        595                 600                 605             
Glu Glu Leu Asp Pro Gln Ser Val Glu Arg Lys Thr Ile Ser Pro Gly
    610                 615                 620                 
Tyr Ala Ile Thr Ile His Ser Gly Thr Phe Thr Trp Ala Gln Asp Leu
625                 630                 635                 640 
Pro Pro Thr Leu His Ser Leu Asp Ile Gln Val Pro Lys Gly Ala Leu
                645                 650                 655     
Val Ala Val Val Gly Pro Val Gly Cys Gly Lys Ser Ser Leu Val Ser
            660                 665                 670         
Ala Leu Leu Gly Glu Met Glu Lys Leu Glu Gly Lys Val His Met Lys
        675                 680                 685             
Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Cys Thr
    690                 695                 700                 
Leu Gln Glu Asn Val Leu Phe Gly Lys Ala Leu Asn Pro Lys Arg Tyr
705                 710                 715                 720 
Gln Gln Thr Leu Glu Ala Cys Ala Leu Leu Ala Asp Leu Glu Met Leu
                725                 730                 735     
Pro Gly Gly Asp Gln Thr Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser
            740                 745                 750         
Gly Gly Gln Arg Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser Asp
        755                 760                 765             
Ala Asp Ile Phe Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ser His
    770                 775                 780                 
Val Ala Lys His Ile Phe Asp His Val Ile Gly Pro Glu Gly Val Leu
785                 790                 795                 800 
Ala Gly Lys Thr Arg Val Leu Val Thr His Gly Ile Ser Phe Leu Pro
                805                 810                 815     
Gln Thr Asp Phe Ile Ile Val Leu Ala Asp Gly Gln Val Ser Glu Met
            820                 825                 830         
Gly Pro Tyr Pro Ala Leu Leu Gln Arg Asn Gly Ser Phe Ala Asn Phe
        835                 840                 845             
Leu Cys Asn Tyr Ala Pro Asp Glu Asp Gln Gly His Leu Glu Asp Ser
    850                 855                 860                 
Trp Thr Ala Leu Glu Gly Ala Glu Asp Lys Glu Ala Leu Leu Ile Glu
865                 870                 875                 880 
Asp Thr Leu Ser Asn His Thr Asp Leu Thr Asp Asn Asp Pro Val Thr
                885                 890                 895     
Tyr Val Val Gln Lys Gln Phe Met Arg Gln Leu Ser Ala Leu Ser Ser
            900                 905                 910         
Asp Gly Glu Gly Gln Gly Arg Pro Val Pro Arg Arg His Leu Gly Pro
        915                 920                 925             
Ser Glu Lys Val Gln Val Thr Glu Ala Lys Ala Asp Gly Ala Leu Thr
    930                 935                 940                 
Gln Glu Glu Lys Ala Ala Ile Gly Thr Val Glu Leu Ser Val Phe Trp
945                 950                 955                 960 
Asp Tyr Ala Lys Ala Val Gly Leu Cys Thr Thr Leu Ala Ile Cys Leu
                965                 970                 975     
Leu Tyr Val Gly Gln Ser Ala Ala Ala Ile Gly Ala Asn Val Trp Leu
            980                 985                 990         
Ser Ala Trp Thr Asn Asp Ala Met Ala Asp Ser Arg Gln Asn Asn Thr
        995                 1000                1005            
Ser Leu Arg Leu Gly Val Tyr Ala Ala Leu Gly Ile Leu Gln Gly Phe
    1010                1015                1020                
Leu Val Met Leu Ala Ala Met Ala Met Ala Ala Gly Gly Ile Gln Ala
1025                1030                1035                1040
Ala Arg Val Leu His Gln Ala Leu Leu His Asn Lys Ile Arg Ser Pro
                1045                1050                1055    
Gln Ser Phe Phe Asp Thr Thr Pro Ser Gly Arg Ile Leu Asn Cys Phe
            1060                1065                1070        
Ser Lys Asp Ile Tyr Val Val Asp Glu Val Leu Ala Pro Val Ile Leu
        1075                1080                1085            
Met Leu Leu Asn Ser Phe Phe Asn Ala Ile Ser Thr Leu Val Val Ile
    1090                1095                1100                
Met Ala Ser Thr Pro Leu Phe Thr Val Val Ile Leu Pro Leu Ala Val
1105                1110                1115                1120
Leu Tyr Thr Leu Val Gln Arg Phe Tyr Ala Ala Thr Ser Arg Gln Leu
                1125                1130                1135    
Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Ile Tyr Ser His Phe Ser
            1140                1145                1150        
Glu Thr Val Thr Gly Ala Ser Val Ile Arg Ala Tyr Asn Arg Ser Arg
        1155                1160                1165            
Asp Phe Glu Ile Ile Ser Asp Thr Lys Val Asp Ala Asn Gln Arg Ser
    1170                1175                1180                
Cys Tyr Pro Tyr Ile Ile Ser Asn Arg Ser Glu Ala Ala Ser Leu Ala
1185                1190                1195                1200
Pro Cys Ser Ser Arg Asn Ser Gln Gln Ala Leu Trp Cys Ser Gly Ser
                1205                1210                1215    
Leu Ser Leu Leu Ser Pro Lys Gln Lys Thr Gly Pro Ala Leu Pro Leu
            1220                1225                1230        
Pro His Phe Leu Leu Ile
        1235            


<210> 9231
<211> 1527
<212> PRT
<213> Homo sapiens

<400> 9231
Met Asp Ala Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp
 1               5                  10                  15      
Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr Pro Cys Phe
            20                  25                  30          
Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu Trp Val Ala
        35                  40                  45              
Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg Gly Tyr Ile
    50                  55                  60                  
Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly Val Leu Leu
65                  70                  75                  80  
Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His Gly Leu Val
                85                  90                  95      
His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro Leu Val Val
            100                 105                 110         
Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr Glu Arg Leu
        115                 120                 125             
Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp Phe Leu Cys
    130                 135                 140                 
Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu Leu Ala Lys
145                 150                 155                 160 
Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr Phe Tyr Ile
                165                 170                 175     
His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys Phe Arg Glu
            180                 185                 190         
Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn Pro Tyr Pro
        195                 200                 205             
Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp Trp Phe Thr
    210                 215                 220                 
Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu Lys Asp Leu
225                 230                 235                 240 
Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val Gln Gln Leu
                245                 250                 255     
Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg His Lys Ala
            260                 265                 270         
Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu Val Leu Leu
        275                 280                 285             
Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys Ala Leu Leu
    290                 295                 300                 
Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe Lys Leu Ile
305                 310                 315                 320 
Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser Ile Leu Ile
                325                 330                 335     
Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly Phe Leu Val
            340                 345                 350         
Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu Ile Leu Gln
        355                 360                 365             
His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe Arg Thr Gly
    370                 375                 380                 
Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Val
385                 390                 395                 400 
Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp
                405                 410                 415     
Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu Leu Trp Ser
            420                 425                 430         
Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp Gln Asn Leu
        435                 440                 445             
Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu Leu Ile Pro
    450                 455                 460                 
Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln Val Lys Gln
465                 470                 475                 480 
Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu Ile Leu Asn
                485                 490                 495     
Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser Phe Leu Lys
            500                 505                 510         
Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu Arg Thr Ala
        515                 520                 525             
Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys Ser Pro Phe
    530                 535                 540                 
Leu Val Thr Leu Ile Thr Leu Trp Val Tyr Val Tyr Val Asp Pro Asn
545                 550                 555                 560 
Asn Val Leu Asp Ala Glu Lys Ala Phe Val Ser Val Ser Leu Phe Asn
                565                 570                 575     
Ile Leu Arg Leu Pro Leu Asn Met Leu Pro Gln Leu Ile Ser Asn Leu
            580                 585                 590         
Thr Gln Ala Ser Val Ser Leu Lys Arg Ile Gln Gln Phe Leu Ser Gln
        595                 600                 605             
Glu Glu Leu Asp Pro Gln Ser Val Glu Arg Lys Thr Ile Ser Pro Gly
    610                 615                 620                 
Tyr Ala Ile Thr Ile His Ser Gly Thr Phe Thr Trp Ala Gln Asp Leu
625                 630                 635                 640 
Pro Pro Thr Leu His Ser Leu Asp Ile Gln Val Pro Lys Gly Ala Leu
                645                 650                 655     
Val Ala Val Val Gly Pro Val Gly Cys Gly Lys Ser Ser Leu Val Ser
            660                 665                 670         
Ala Leu Leu Gly Glu Met Glu Lys Leu Glu Gly Lys Val His Met Lys
        675                 680                 685             
Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Cys Thr
    690                 695                 700                 
Leu Gln Glu Asn Val Leu Phe Gly Lys Ala Leu Asn Pro Lys Arg Tyr
705                 710                 715                 720 
Gln Gln Thr Leu Glu Ala Cys Ala Leu Leu Ala Asp Leu Glu Met Leu
                725                 730                 735     
Pro Gly Gly Asp Gln Thr Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser
            740                 745                 750         
Gly Gly Gln Arg Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser Asp
        755                 760                 765             
Ala Asp Ile Phe Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ser His
    770                 775                 780                 
Val Ala Lys His Ile Phe Asp His Val Ile Gly Pro Glu Gly Val Leu
785                 790                 795                 800 
Ala Gly Lys Thr Arg Val Leu Val Thr His Gly Ile Ser Phe Leu Pro
                805                 810                 815     
Gln Thr Asp Phe Ile Ile Val Leu Ala Asp Gly Gln Val Ser Glu Met
            820                 825                 830         
Gly Pro Tyr Pro Ala Leu Leu Gln Arg Asn Gly Ser Phe Ala Asn Phe
        835                 840                 845             
Leu Cys Asn Tyr Ala Pro Asp Glu Asp Gln Gly His Leu Glu Asp Ser
    850                 855                 860                 
Trp Thr Ala Leu Glu Gly Ala Glu Asp Lys Glu Ala Leu Leu Ile Glu
865                 870                 875                 880 
Asp Thr Leu Ser Asn His Thr Asp Leu Thr Asp Asn Asp Pro Val Thr
                885                 890                 895     
Tyr Val Val Gln Lys Gln Phe Met Arg Gln Leu Ser Ala Leu Ser Ser
            900                 905                 910         
Asp Gly Glu Gly Gln Gly Arg Pro Val Pro Arg Arg His Leu Gly Pro
        915                 920                 925             
Ser Glu Lys Val Gln Val Thr Glu Ala Lys Ala Asp Gly Ala Leu Thr
    930                 935                 940                 
Gln Glu Glu Lys Ala Ala Ile Gly Thr Val Glu Leu Ser Val Phe Trp
945                 950                 955                 960 
Asp Tyr Ala Lys Ala Val Gly Leu Cys Thr Thr Leu Ala Ile Cys Leu
                965                 970                 975     
Leu Tyr Val Gly Gln Ser Ala Ala Ala Ile Gly Ala Asn Val Trp Leu
            980                 985                 990         
Ser Ala Trp Thr Asn Asp Ala Met Ala Asp Ser Arg Gln Asn Asn Thr
        995                 1000                1005            
Ser Leu Arg Leu Gly Val Tyr Ala Ala Leu Gly Ile Leu Gln Gly Phe
    1010                1015                1020                
Leu Val Met Leu Ala Ala Met Ala Met Ala Ala Gly Gly Ile Gln Ala
1025                1030                1035                1040
Ala Arg Val Leu His Gln Ala Leu Leu His Asn Lys Ile Arg Ser Pro
                1045                1050                1055    
Gln Ser Phe Phe Asp Thr Thr Pro Ser Gly Arg Ile Leu Asn Cys Phe
            1060                1065                1070        
Ser Lys Asp Ile Tyr Val Val Asp Glu Val Leu Ala Pro Val Ile Leu
        1075                1080                1085            
Met Leu Leu Asn Ser Phe Phe Asn Ala Ile Ser Thr Leu Val Val Ile
    1090                1095                1100                
Met Ala Ser Thr Pro Leu Phe Thr Val Val Ile Leu Pro Leu Ala Val
1105                1110                1115                1120
Leu Tyr Thr Leu Val Gln Arg Phe Tyr Ala Ala Thr Ser Arg Gln Leu
                1125                1130                1135    
Lys Arg Leu Glu Ser Val Ser Arg Ser Pro Ile Tyr Ser His Phe Ser
            1140                1145                1150        
Glu Thr Val Thr Gly Ala Ser Val Ile Arg Ala Tyr Asn Arg Ser Arg
        1155                1160                1165            
Asp Phe Glu Ile Ile Ser Asp Thr Lys Val Asp Ala Asn Gln Arg Ser
    1170                1175                1180                
Cys Tyr Pro Tyr Ile Ile Ser Asn Arg Trp Leu Ser Ile Gly Val Glu
1185                1190                1195                1200
Phe Val Gly Asn Cys Val Val Leu Phe Ala Ala Leu Phe Ala Val Ile
                1205                1210                1215    
Gly Arg Ser Ser Leu Asn Pro Gly Leu Val Gly Leu Ser Val Ser Tyr
            1220                1225                1230        
Ser Leu Gln Val Thr Phe Ala Leu Asn Trp Met Ile Arg Met Met Ser
        1235                1240                1245            
Asp Leu Glu Ser Asn Ile Val Ala Val Glu Arg Val Lys Glu Tyr Ser
    1250                1255                1260                
Lys Thr Glu Thr Glu Ala Pro Trp Val Val Glu Gly Ser Arg Pro Pro
1265                1270                1275                1280
Glu Gly Trp Pro Pro Arg Gly Glu Val Glu Phe Arg Asn Tyr Ser Val
                1285                1290                1295    
Arg Tyr Arg Pro Gly Leu Asp Leu Val Leu Arg Asp Leu Ser Leu His
            1300                1305                1310        
Val His Gly Gly Glu Lys Val Gly Ile Val Gly Arg Thr Gly Ala Gly
        1315                1320                1325            
Lys Ser Ser Met Thr Leu Cys Leu Phe Arg Ile Leu Glu Ala Ala Lys
    1330                1335                1340                
Gly Glu Ile Arg Ile Asp Gly Leu Asn Val Ala Asp Ile Gly Leu His
1345                1350                1355                1360
Asp Leu Arg Ser Gln Leu Thr Ile Ile Pro Gln Asp Pro Ile Leu Phe
                1365                1370                1375    
Ser Gly Thr Leu Arg Met Asn Leu Asp Pro Phe Gly Ser Tyr Ser Glu
            1380                1385                1390        
Glu Asp Ile Trp Trp Ala Leu Glu Leu Ser His Leu His Thr Phe Val
        1395                1400                1405            
Ser Ser Gln Pro Ala Gly Leu Asp Phe Gln Cys Ser Glu Gly Gly Glu
    1410                1415                1420                
Asn Leu Ser Val Gly Gln Arg Gln Leu Val Cys Leu Ala Arg Ala Leu
1425                1430                1435                1440
Leu Arg Lys Ser Arg Ile Leu Val Leu Asp Glu Ala Thr Ala Ala Ile
                1445                1450                1455    
Asp Leu Glu Thr Asp Asn Leu Ile Gln Ala Thr Ile Arg Thr Gln Phe
            1460                1465                1470        
Asp Thr Cys Thr Val Leu Thr Ile Ala His Arg Leu Asn Thr Ile Met
        1475                1480                1485            
Asp Tyr Thr Arg Val Leu Val Leu Asp Lys Gly Val Val Ala Glu Phe
    1490                1495                1500                
Asp Ser Pro Ala Asn Leu Ile Ala Ala Arg Gly Ile Phe Tyr Gly Met
1505                1510                1515                1520
Ala Arg Asp Ala Gly Leu Ala
                1525        


<210> 9232
<211> 924
<212> PRT
<213> Homo sapiens

<400> 9232
Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe
 1               5                  10                  15      
Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala
            20                  25                  30          
Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp
        35                  40                  45              
Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly
    50                  55                  60                  
Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu
65                  70                  75                  80  
Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu
                85                  90                  95      
Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp
            100                 105                 110         
Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln
        115                 120                 125             
Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe
    130                 135                 140                 
Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser
145                 150                 155                 160 
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln
                165                 170                 175     
Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr
            180                 185                 190         
Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala
        195                 200                 205             
Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu
    210                 215                 220                 
Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln
225                 230                 235                 240 
Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile
                245                 250                 255     
Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys
            260                 265                 270         
Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn
        275                 280                 285             
Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln
    290                 295                 300                 
Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile
305                 310                 315                 320 
Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile
                325                 330                 335     
Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser
            340                 345                 350         
Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp
        355                 360                 365             
Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu
    370                 375                 380                 
Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser
385                 390                 395                 400 
Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr
                405                 410                 415     
Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp
            420                 425                 430         
Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu
        435                 440                 445             
Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro
    450                 455                 460                 
Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe
465                 470                 475                 480 
Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly
                485                 490                 495     
Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly
            500                 505                 510         
Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys
        515                 520                 525             
Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr
    530                 535                 540                 
Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys
545                 550                 555                 560 
Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys
                565                 570                 575     
Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val
            580                 585                 590         
Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val
        595                 600                 605             
Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser
    610                 615                 620                 
Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr
625                 630                 635                 640 
Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser
                645                 650                 655     
Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala
            660                 665                 670         
Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys
        675                 680                 685             
Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala
    690                 695                 700                 
Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp
705                 710                 715                 720 
Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys
                725                 730                 735     
Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr
            740                 745                 750         
Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val
        755                 760                 765             
Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe
    770                 775                 780                 
Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val
785                 790                 795                 800 
Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu
                805                 810                 815     
Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser
            820                 825                 830         
Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile
        835                 840                 845             
Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys
    850                 855                 860                 
Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro
865                 870                 875                 880 
Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val
                885                 890                 895     
Asp Pro Asn Asn Phe Phe Phe Gly Cys Thr Val Glu Leu Gly Leu His
            900                 905                 910         
Phe Lys Leu Thr Phe Ser Arg Asn Gln Ser Asn Leu
        915                 920                 


<210> 9233
<211> 915
<212> PRT
<213> Homo sapiens

<400> 9233
Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe
 1               5                  10                  15      
Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala
            20                  25                  30          
Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp
        35                  40                  45              
Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly
    50                  55                  60                  
Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu
65                  70                  75                  80  
Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu
                85                  90                  95      
Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp
            100                 105                 110         
Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln
        115                 120                 125             
Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe
    130                 135                 140                 
Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser
145                 150                 155                 160 
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln
                165                 170                 175     
Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr
            180                 185                 190         
Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala
        195                 200                 205             
Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu
    210                 215                 220                 
Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln
225                 230                 235                 240 
Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile
                245                 250                 255     
Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys
            260                 265                 270         
Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn
        275                 280                 285             
Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln
    290                 295                 300                 
Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile
305                 310                 315                 320 
Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile
                325                 330                 335     
Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser
            340                 345                 350         
Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp
        355                 360                 365             
Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu
    370                 375                 380                 
Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser
385                 390                 395                 400 
Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr
                405                 410                 415     
Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp
            420                 425                 430         
Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu
        435                 440                 445             
Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro
    450                 455                 460                 
Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe
465                 470                 475                 480 
Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly
                485                 490                 495     
Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly
            500                 505                 510         
Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys
        515                 520                 525             
Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr
    530                 535                 540                 
Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys
545                 550                 555                 560 
Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys
                565                 570                 575     
Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val
            580                 585                 590         
Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val
        595                 600                 605             
Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser
    610                 615                 620                 
Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr
625                 630                 635                 640 
Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser
                645                 650                 655     
Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala
            660                 665                 670         
Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys
        675                 680                 685             
Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala
    690                 695                 700                 
Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp
705                 710                 715                 720 
Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys
                725                 730                 735     
Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr
            740                 745                 750         
Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val
        755                 760                 765             
Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe
    770                 775                 780                 
Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val
785                 790                 795                 800 
Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu
                805                 810                 815     
Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser
            820                 825                 830         
Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile
        835                 840                 845             
Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys
    850                 855                 860                 
Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro
865                 870                 875                 880 
Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val
                885                 890                 895     
Asp Pro Asn Ser Pro Ala Ala Lys Lys Lys Tyr Val Ser Tyr Asn Asn
            900                 905                 910         
Leu Val Ile
        915 


<210> 9234
<211> 922
<212> PRT
<213> Homo sapiens

<400> 9234
Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe
 1               5                  10                  15      
Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala
            20                  25                  30          
Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp
        35                  40                  45              
Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly
    50                  55                  60                  
Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu
65                  70                  75                  80  
Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu
                85                  90                  95      
Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp
            100                 105                 110         
Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln
        115                 120                 125             
Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe
    130                 135                 140                 
Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser
145                 150                 155                 160 
Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln
                165                 170                 175     
Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr
            180                 185                 190         
Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala
        195                 200                 205             
Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu
    210                 215                 220                 
Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln
225                 230                 235                 240 
Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile
                245                 250                 255     
Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys
            260                 265                 270         
Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn
        275                 280                 285             
Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln
    290                 295                 300                 
Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile
305                 310                 315                 320 
Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile
                325                 330                 335     
Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser
            340                 345                 350         
Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp
        355                 360                 365             
Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu
    370                 375                 380                 
Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser
385                 390                 395                 400 
Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr
                405                 410                 415     
Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp
            420                 425                 430         
Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu
        435                 440                 445             
Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro
    450                 455                 460                 
Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe
465                 470                 475                 480 
Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly
                485                 490                 495     
Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly
            500                 505                 510         
Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys
        515                 520                 525             
Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr
    530                 535                 540                 
Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys
545                 550                 555                 560 
Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys
                565                 570                 575     
Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val
            580                 585                 590         
Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val
        595                 600                 605             
Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser
    610                 615                 620                 
Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr
625                 630                 635                 640 
Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser
                645                 650                 655     
Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala
            660                 665                 670         
Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys
        675                 680                 685             
Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala
    690                 695                 700                 
Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp
705                 710                 715                 720 
Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys
                725                 730                 735     
Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr
            740                 745                 750         
Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val
        755                 760                 765             
Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe
    770                 775                 780                 
Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val
785                 790                 795                 800 
Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu
                805                 810                 815     
Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser
            820                 825                 830         
Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile
        835                 840                 845             
Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys
    850                 855                 860                 
Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro
865                 870                 875                 880 
Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val
                885                 890                 895     
Asp Pro Asn Asn Cys Ile Pro Pro Val Arg Lys Ser Val Gln Lys Ser
            900                 905                 910         
Val Thr Trp Tyr Thr Ile Pro Pro Thr Val
        915                 920         


<210> 9235
<211> 584
<212> PRT
<213> Homo sapiens

<400> 9235
Met Asn Ser Pro Gly Gly Arg Gly Lys Lys Lys Gly Ser Gly Gly Ala
 1               5                  10                  15      
Ser Asn Pro Val Pro Pro Arg Pro Pro Pro Pro Cys Leu Ala Pro Ala
            20                  25                  30          
Pro Pro Ala Ala Gly Pro Ala Pro Pro Pro Glu Ser Pro His Lys Arg
        35                  40                  45              
Asn Leu Tyr Tyr Phe Ser Tyr Pro Leu Phe Val Gly Phe Ala Leu Leu
    50                  55                  60                  
Arg Leu Val Ala Phe His Leu Gly Leu Leu Phe Val Trp Leu Cys Gln
65                  70                  75                  80  
Arg Phe Ser Arg Ala Leu Met Ala Ala Lys Arg Ser Ser Gly Ala Ala
                85                  90                  95      
Pro Ala Pro Ala Ser Ala Ser Ala Pro Ala Pro Val Pro Gly Gly Glu
            100                 105                 110         
Ala Glu Arg Val Arg Val Phe His Lys Gln Ala Phe Glu Tyr Ile Ser
        115                 120                 125             
Ile Ala Leu Arg Ile Asp Glu Asp Glu Lys Ala Gly Gln Lys Glu Gln
    130                 135                 140                 
Ala Val Glu Trp Tyr Lys Lys Gly Ile Glu Glu Leu Glu Lys Gly Ile
145                 150                 155                 160 
Ala Val Ile Val Thr Gly Gln Gly Glu Gln Cys Glu Arg Ala Arg Arg
                165                 170                 175     
Leu Gln Ala Lys Met Met Thr Asn Leu Val Met Ala Lys Asp Arg Leu
            180                 185                 190         
Gln Leu Leu Glu Ser Gly Ala Val Pro Lys Arg Lys Asp Pro Leu Thr
        195                 200                 205             
His Thr Ser Asn Ser Leu Pro Arg Ser Lys Thr Val Met Lys Thr Gly
    210                 215                 220                 
Ser Ala Gly Leu Ser Gly His His Arg Ala Pro Ser Tyr Ser Gly Leu
225                 230                 235                 240 
Ser Met Val Ser Gly Val Lys Gln Gly Ser Gly Pro Ala Pro Thr Thr
                245                 250                 255     
His Lys Gly Thr Pro Lys Thr Asn Arg Thr Asn Lys Pro Ser Thr Pro
            260                 265                 270         
Thr Thr Ala Thr Arg Lys Lys Lys Asp Leu Lys Asn Phe Arg Asn Val
        275                 280                 285             
Asp Ser Asn Leu Ala Asn Leu Ile Met Asn Glu Ile Val Asp Asn Gly
    290                 295                 300                 
Thr Ala Val Lys Phe Asp Asp Ile Ala Gly Gln Asp Leu Ala Lys Gln
305                 310                 315                 320 
Ala Leu Gln Glu Ile Val Ile Leu Pro Ser Leu Arg Pro Glu Leu Phe
                325                 330                 335     
Thr Gly Leu Arg Ala Pro Ala Arg Gly Leu Leu Leu Phe Gly Pro Pro
            340                 345                 350         
Gly Asn Gly Lys Thr Met Leu Ala Lys Ala Val Ala Ala Glu Ser Asn
        355                 360                 365             
Ala Thr Phe Phe Asn Ile Ser Ala Ala Ser Leu Thr Ser Lys Tyr Val
    370                 375                 380                 
Gly Glu Gly Glu Lys Leu Val Arg Ala Leu Phe Ala Val Ala Arg Glu
385                 390                 395                 400 
Leu Gln Pro Ser Ile Ile Phe Ile Asp Glu Val Asp Ser Leu Leu Cys
                405                 410                 415     
Glu Arg Arg Glu Gly Glu His Asp Ala Ser Arg Arg Leu Lys Thr Glu
            420                 425                 430         
Phe Leu Ile Glu Phe Asp Gly Val Gln Ser Ala Gly Asp Asp Arg Val
        435                 440                 445             
Leu Val Met Gly Ala Thr Asn Arg Pro Gln Glu Leu Asp Glu Ala Val
    450                 455                 460                 
Leu Arg Arg Phe Ile Lys Arg Val Tyr Val Ser Leu Pro Asn Glu Glu
465                 470                 475                 480 
Thr Arg Leu Leu Leu Leu Lys Asn Leu Leu Cys Lys Gln Gly Ser Pro
                485                 490                 495     
Leu Thr Gln Lys Glu Leu Ala Gln Leu Ala Arg Met Thr Asp Gly Tyr
            500                 505                 510         
Ser Gly Ser Asp Leu Thr Ala Leu Ala Lys Asp Ala Ala Leu Gly Pro
        515                 520                 525             
Ile Arg Glu Leu Lys Pro Glu Gln Val Lys Asn Met Ser Ala Ser Glu
    530                 535                 540                 
Met Arg Asn Ile Arg Leu Ser Asp Phe Thr Glu Ser Leu Lys Lys Ile
545                 550                 555                 560 
Lys Arg Ser Val Ser Pro Gln Thr Leu Glu Ala Tyr Ile Arg Trp Asn
                565                 570                 575     
Lys Asp Phe Gly Asp Thr Thr Val
            580                 


<210> 9236
<211> 616
<212> PRT
<213> Homo sapiens

<400> 9236
Met Asn Ser Pro Gly Gly Arg Gly Lys Lys Lys Gly Ser Gly Gly Ala
 1               5                  10                  15      
Ser Asn Pro Val Pro Pro Arg Pro Pro Pro Pro Cys Leu Ala Pro Ala
            20                  25                  30          
Pro Pro Ala Ala Gly Pro Ala Pro Pro Pro Glu Ser Pro His Lys Arg
        35                  40                  45              
Asn Leu Tyr Tyr Phe Ser Tyr Pro Leu Phe Val Gly Phe Ala Leu Leu
    50                  55                  60                  
Arg Leu Val Ala Phe His Leu Gly Leu Leu Phe Val Trp Leu Cys Gln
65                  70                  75                  80  
Arg Phe Ser Arg Ala Leu Met Ala Ala Lys Arg Ser Ser Gly Ala Ala
                85                  90                  95      
Pro Ala Pro Ala Ser Ala Ser Ala Pro Ala Pro Val Pro Gly Gly Glu
            100                 105                 110         
Ala Glu Arg Val Arg Val Phe His Lys Gln Ala Phe Glu Tyr Ile Ser
        115                 120                 125             
Ile Ala Leu Arg Ile Asp Glu Asp Glu Lys Ala Gly Gln Lys Glu Gln
    130                 135                 140                 
Ala Val Glu Trp Tyr Lys Lys Gly Ile Glu Glu Leu Glu Lys Gly Ile
145                 150                 155                 160 
Ala Val Ile Val Thr Gly Gln Gly Glu Gln Cys Glu Arg Ala Arg Arg
                165                 170                 175     
Leu Gln Ala Lys Met Met Thr Asn Leu Val Met Ala Lys Asp Arg Leu
            180                 185                 190         
Gln Leu Leu Glu Lys Met Gln Pro Val Leu Pro Phe Ser Lys Ser Gln
        195                 200                 205             
Thr Asp Val Tyr Asn Asp Ser Thr Asn Leu Ala Cys Arg Asn Gly His
    210                 215                 220                 
Leu Gln Ser Glu Ser Gly Ala Val Pro Lys Arg Lys Asp Pro Leu Thr
225                 230                 235                 240 
His Thr Ser Asn Ser Leu Pro Arg Ser Lys Thr Val Met Lys Thr Gly
                245                 250                 255     
Ser Ala Gly Leu Ser Gly His His Arg Ala Pro Ser Tyr Ser Gly Leu
            260                 265                 270         
Ser Met Val Ser Gly Val Lys Gln Gly Ser Gly Pro Ala Pro Thr Thr
        275                 280                 285             
His Lys Gly Thr Pro Lys Thr Asn Arg Thr Asn Lys Pro Ser Thr Pro
    290                 295                 300                 
Thr Thr Ala Thr Arg Lys Lys Lys Asp Leu Lys Asn Phe Arg Asn Val
305                 310                 315                 320 
Asp Ser Asn Leu Ala Asn Leu Ile Met Asn Glu Ile Val Asp Asn Gly
                325                 330                 335     
Thr Ala Val Lys Phe Asp Asp Ile Ala Gly Gln Asp Leu Ala Lys Gln
            340                 345                 350         
Ala Leu Gln Glu Ile Val Ile Leu Pro Ser Leu Arg Pro Glu Leu Phe
        355                 360                 365             
Thr Gly Leu Arg Ala Pro Ala Arg Gly Leu Leu Leu Phe Gly Pro Pro
    370                 375                 380                 
Gly Asn Gly Lys Thr Met Leu Ala Lys Ala Val Ala Ala Glu Ser Asn
385                 390                 395                 400 
Ala Thr Phe Phe Asn Ile Ser Ala Ala Ser Leu Thr Ser Lys Tyr Val
                405                 410                 415     
Gly Glu Gly Glu Lys Leu Val Arg Ala Leu Phe Ala Val Ala Arg Glu
            420                 425                 430         
Leu Gln Pro Ser Ile Ile Phe Ile Asp Glu Val Asp Ser Leu Leu Cys
        435                 440                 445             
Glu Arg Arg Glu Gly Glu His Asp Ala Ser Arg Arg Leu Lys Thr Glu
    450                 455                 460                 
Phe Leu Ile Glu Phe Asp Gly Val Gln Ser Ala Gly Asp Asp Arg Val
465                 470                 475                 480 
Leu Val Met Gly Ala Thr Asn Arg Pro Gln Glu Leu Asp Glu Ala Val
                485                 490                 495     
Leu Arg Arg Phe Ile Lys Arg Val Tyr Val Ser Leu Pro Asn Glu Glu
            500                 505                 510         
Thr Arg Leu Leu Leu Leu Lys Asn Leu Leu Cys Lys Gln Gly Ser Pro
        515                 520                 525             
Leu Thr Gln Lys Glu Leu Ala Gln Leu Ala Arg Met Thr Asp Gly Tyr
    530                 535                 540                 
Ser Gly Ser Asp Leu Thr Ala Leu Ala Lys Asp Ala Ala Leu Gly Pro
545                 550                 555                 560 
Ile Arg Glu Leu Lys Pro Glu Gln Val Lys Asn Met Ser Ala Ser Glu
                565                 570                 575     
Met Arg Asn Ile Arg Leu Ser Asp Phe Thr Glu Ser Leu Lys Lys Ile
            580                 585                 590         
Lys Arg Ser Val Ser Pro Gln Thr Leu Glu Ala Tyr Ile Arg Trp Asn
        595                 600                 605             
Lys Asp Phe Gly Asp Thr Thr Val
    610                 615     


<210> 9237
<211> 2000
<212> PRT
<213> Homo sapiens

<400> 9237
Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu
 1               5                  10                  15      
Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu
            20                  25                  30          
Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys
        35                  40                  45              
Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile
    50                  55                  60                  
Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu
65                  70                  75                  80  
Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly
                85                  90                  95      
Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr
            100                 105                 110         
Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser
        115                 120                 125             
Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe
    130                 135                 140                 
Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
145                 150                 155                 160 
Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg
                165                 170                 175     
Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp
            180                 185                 190         
Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser
        195                 200                 205             
Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu
    210                 215                 220                 
Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu
225                 230                 235                 240 
Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe
                245                 250                 255     
Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
            260                 265                 270         
Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu
        275                 280                 285             
Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr
    290                 295                 300                 
Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly
305                 310                 315                 320 
Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu
                325                 330                 335     
Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys
            340                 345                 350         
Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr
        355                 360                 365             
Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr
    370                 375                 380                 
Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr
385                 390                 395                 400 
Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val
                405                 410                 415     
Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln
            420                 425                 430         
Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met
        435                 440                 445             
Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala
    450                 455                 460                 
Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu
465                 470                 475                 480 
Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala
                485                 490                 495     
Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu
            500                 505                 510         
Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser
        515                 520                 525             
Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn
    530                 535                 540                 
Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu
545                 550                 555                 560 
Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser
                565                 570                 575     
Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp
            580                 585                 590         
Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg
        595                 600                 605             
Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn
    610                 615                 620                 
Val Ser Gln Ala Ser Met Ser Ser Arg Met Val Pro Gly Leu Pro Ala
625                 630                 635                 640 
Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu
                645                 650                 655     
Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Pro Pro
            660                 665                 670         
Glu Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser
        675                 680                 685             
Tyr Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg
    690                 695                 700                 
Ala Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu
705                 710                 715                 720 
Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val
                725                 730                 735     
Phe Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu
            740                 745                 750         
Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile
        755                 760                 765             
Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met
    770                 775                 780                 
Thr Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr
785                 790                 795                 800 
Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro
                805                 810                 815     
Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val
            820                 825                 830         
Ser Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser
        835                 840                 845             
Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser
    850                 855                 860                 
Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly
865                 870                 875                 880 
Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe
                885                 890                 895     
Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val
            900                 905                 910         
Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp
        915                 920                 925             
Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp
    930                 935                 940                 
Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys
945                 950                 955                 960 
Leu Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu
                965                 970                 975     
Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu
            980                 985                 990         
Ala Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val
        995                 1000                1005            
Gly Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu
    1010                1015                1020                
Cys Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His
1025                1030                1035                1040
Glu Gly Asn Lys Ile Asp Ser Cys Met Ser Asn Asn Thr Gly Ile Glu
                1045                1050                1055    
Ile Ser Lys Glu Leu Asn Tyr Leu Arg Asp Gly Asn Gly Thr Thr Ser
            1060                1065                1070        
Gly Val Gly Thr Gly Ser Ser Val Glu Lys Tyr Val Ile Asp Glu Asn
        1075                1080                1085            
Asp Tyr Met Ser Phe Ile Asn Asn Pro Ser Leu Thr Val Thr Val Pro
    1090                1095                1100                
Ile Ala Val Gly Glu Ser Asp Phe Glu Asn Leu Asn Thr Glu Glu Phe
1105                1110                1115                1120
Ser Ser Glu Ser Glu Leu Glu Glu Ser Lys Glu Lys Leu Asn Ala Thr
                1125                1130                1135    
Ser Ser Ser Glu Gly Ser Thr Val Asp Val Val Leu Pro Arg Glu Gly
            1140                1145                1150        
Glu Gln Ala Glu Thr Glu Pro Glu Glu Asp Leu Lys Pro Glu Ala Cys
        1155                1160                1165            
Phe Thr Glu Gly Cys Ile Lys Lys Phe Pro Phe Cys Gln Val Ser Thr
    1170                1175                1180                
Glu Glu Gly Lys Gly Lys Ile Trp Trp Asn Leu Arg Lys Thr Cys Tyr
1185                1190                1195                1200
Ser Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile
                1205                1210                1215    
Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Gln
            1220                1225                1230        
Arg Lys Thr Ile Lys Thr Met Leu Glu Tyr Ala Asp Lys Val Phe Thr
        1235                1240                1245            
Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe
    1250                1255                1260                
Gln Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val
1265                1270                1275                1280
Asp Val Ser Leu Val Ser Leu Val Ala Asn Ala Leu Gly Tyr Ser Glu
                1285                1290                1295    
Leu Gly Ala Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu
            1300                1305                1310        
Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu
        1315                1320                1325            
Val Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile
    1330                1335                1340                
Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys
1345                1350                1355                1360
Phe Tyr His Cys Val Asn Met Thr Thr Gly Asn Met Phe Asp Ile Ser
                1365                1370                1375    
Asp Val Asn Asn Leu Ser Asp Cys Gln Ala Leu Gly Lys Gln Ala Arg
            1380                1385                1390        
Trp Lys Asn Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly Tyr Leu
        1395                1400                1405            
Ala Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr
    1410                1415                1420                
Ala Ala Val Asp Ser Arg Asp Val Lys Leu Gln Pro Val Tyr Glu Glu
1425                1430                1435                1440
Asn Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser
                1445                1450                1455    
Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe Asn
            1460                1465                1470        
Gln Gln Lys Lys Lys Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu
        1475                1480                1485            
Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro
    1490                1495                1500                
Gln Lys Pro Ile Pro Arg Pro Ala Asn Lys Phe Gln Gly Met Val Phe
1505                1510                1515                1520
Asp Phe Val Thr Arg Gln Val Phe Asp Ile Ser Ile Met Ile Leu Ile
                1525                1530                1535    
Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln Gly Lys
            1540                1545                1550        
Tyr Met Thr Leu Val Leu Ser Arg Ile Asn Leu Val Phe Ile Val Leu
        1555                1560                1565            
Phe Thr Gly Glu Phe Val Leu Lys Leu Val Ser Leu Arg His Tyr Tyr
    1570                1575                1580                
Phe Thr Ile Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser
1585                1590                1595                1600
Ile Val Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr Phe Val Ser
                1605                1610                1615    
Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu
            1620                1625                1630        
Arg Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu
        1635                1640                1645            
Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu
    1650                1655                1660                
Val Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr Val
1665                1670                1675                1680
Lys Lys Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Glu Thr Phe Gly
                1685                1690                1695    
Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp
            1700                1705                1710        
Gly Leu Leu Ala Pro Ile Leu Asn Ser Ala Pro Pro Asp Cys Asp Pro
        1715                1720                1725            
Asp Thr Ile His Pro Gly Ser Ser Val Lys Gly Asp Cys Gly Asn Pro
    1730                1735                1740                
Ser Val Gly Ile Phe Phe Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu
1745                1750                1755                1760
Val Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val
                1765                1770                1775    
Ala Thr Glu Glu Ser Ala Glu Pro Leu Ser Glu Asp Asp Phe Glu Met
            1780                1785                1790        
Phe Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile
        1795                1800                1805            
Glu Phe Ser Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu
    1810                1815                1820                
Leu Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro
1825                1830                1835                1840
Met Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala Phe
                1845                1850                1855    
Thr Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Arg Ile
            1860                1865                1870        
Gln Met Glu Asp Arg Phe Met Ala Ser Asn Pro Ser Lys Val Ser Tyr
        1875                1880                1885            
Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu Val Ser Ala
    1890                1895                1900                
Ala Ile Ile Gln Arg Asn Phe Arg Cys Tyr Leu Leu Lys Gln Arg Leu
1905                1910                1915                1920
Lys Asn Ile Ser Ser Asn Tyr Asn Lys Glu Ala Ile Lys Gly Arg Ile
                1925                1930                1935    
Asp Leu Pro Ile Lys Gln Asp Met Ile Ile Asp Lys Leu Asn Gly Asn
            1940                1945                1950        
Ser Thr Pro Glu Lys Thr Asp Gly Ser Ser Ser Thr Thr Ser Pro Pro
        1955                1960                1965            
Ser Tyr Asp Ser Val Thr Lys Pro Asp Lys Glu Lys Phe Glu Lys Asp
    1970                1975                1980                
Lys Pro Glu Lys Glu Ser Lys Gly Lys Glu Val Arg Glu Asn Gln Lys
1985                1990                1995                2000


<210> 9238
<211> 2000
<212> PRT
<213> Homo sapiens

<400> 9238
Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu
 1               5                  10                  15      
Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu
            20                  25                  30          
Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys
        35                  40                  45              
Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile
    50                  55                  60                  
Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu
65                  70                  75                  80  
Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly
                85                  90                  95      
Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr
            100                 105                 110         
Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser
        115                 120                 125             
Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe
    130                 135                 140                 
Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
145                 150                 155                 160 
Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg
                165                 170                 175     
Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp
            180                 185                 190         
Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Asp
        195                 200                 205             
Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu
    210                 215                 220                 
Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu
225                 230                 235                 240 
Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe
                245                 250                 255     
Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
            260                 265                 270         
Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu
        275                 280                 285             
Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr
    290                 295                 300                 
Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly
305                 310                 315                 320 
Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu
                325                 330                 335     
Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys
            340                 345                 350         
Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr
        355                 360                 365             
Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr
    370                 375                 380                 
Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr
385                 390                 395                 400 
Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val
                405                 410                 415     
Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln
            420                 425                 430         
Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met
        435                 440                 445             
Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala
    450                 455                 460                 
Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu
465                 470                 475                 480 
Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala
                485                 490                 495     
Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu
            500                 505                 510         
Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser
        515                 520                 525             
Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn
    530                 535                 540                 
Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu
545                 550                 555                 560 
Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser
                565                 570                 575     
Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp
            580                 585                 590         
Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg
        595                 600                 605             
Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn
    610                 615                 620                 
Val Ser Gln Ala Ser Met Ser Ser Arg Met Val Pro Gly Leu Pro Ala
625                 630                 635                 640 
Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu
                645                 650                 655     
Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Pro Pro
            660                 665                 670         
Glu Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser
        675                 680                 685             
Tyr Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg
    690                 695                 700                 
Ala Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu
705                 710                 715                 720 
Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val
                725                 730                 735     
Phe Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu
            740                 745                 750         
Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile
        755                 760                 765             
Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met
    770                 775                 780                 
Thr Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr
785                 790                 795                 800 
Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro
                805                 810                 815     
Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val
            820                 825                 830         
Ser Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser
        835                 840                 845             
Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser
    850                 855                 860                 
Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly
865                 870                 875                 880 
Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe
                885                 890                 895     
Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val
            900                 905                 910         
Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp
        915                 920                 925             
Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp
    930                 935                 940                 
Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys
945                 950                 955                 960 
Leu Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu
                965                 970                 975     
Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu
            980                 985                 990         
Ala Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val
        995                 1000                1005            
Gly Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu
    1010                1015                1020                
Cys Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His
1025                1030                1035                1040
Glu Gly Asn Lys Ile Asp Ser Cys Met Ser Asn Asn Thr Gly Ile Glu
                1045                1050                1055    
Ile Ser Lys Glu Leu Asn Tyr Leu Arg Asp Gly Asn Gly Thr Thr Ser
            1060                1065                1070        
Gly Val Gly Thr Gly Ser Ser Val Glu Lys Tyr Val Ile Asp Glu Asn
        1075                1080                1085            
Asp Tyr Met Ser Phe Ile Asn Asn Pro Ser Leu Thr Val Thr Val Pro
    1090                1095                1100                
Ile Ala Val Gly Glu Ser Asp Phe Glu Asn Leu Asn Thr Glu Glu Phe
1105                1110                1115                1120
Ser Ser Glu Ser Glu Leu Glu Glu Ser Lys Glu Lys Leu Asn Ala Thr
                1125                1130                1135    
Ser Ser Ser Glu Gly Ser Thr Val Asp Val Val Leu Pro Arg Glu Gly
            1140                1145                1150        
Glu Gln Ala Glu Thr Glu Pro Glu Glu Asp Leu Lys Pro Glu Ala Cys
        1155                1160                1165            
Phe Thr Glu Gly Cys Ile Lys Lys Phe Pro Phe Cys Gln Val Ser Thr
    1170                1175                1180                
Glu Glu Gly Lys Gly Lys Ile Trp Trp Asn Leu Arg Lys Thr Cys Tyr
1185                1190                1195                1200
Ser Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile
                1205                1210                1215    
Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Gln
            1220                1225                1230        
Arg Lys Thr Ile Lys Thr Met Leu Glu Tyr Ala Asp Lys Val Phe Thr
        1235                1240                1245            
Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe
    1250                1255                1260                
Gln Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val
1265                1270                1275                1280
Asp Val Ser Leu Val Ser Leu Val Ala Asn Ala Leu Gly Tyr Ser Glu
                1285                1290                1295    
Leu Gly Ala Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu
            1300                1305                1310        
Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu
        1315                1320                1325            
Val Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile
    1330                1335                1340                
Phe Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys
1345                1350                1355                1360
Phe Tyr His Cys Val Asn Met Thr Thr Gly Asn Met Phe Asp Ile Ser
                1365                1370                1375    
Asp Val Asn Asn Leu Ser Asp Cys Gln Ala Leu Gly Lys Gln Ala Arg
            1380                1385                1390        
Trp Lys Asn Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly Tyr Leu
        1395                1400                1405            
Ala Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr
    1410                1415                1420                
Ala Ala Val Asp Ser Arg Asp Val Lys Leu Gln Pro Val Tyr Glu Glu
1425                1430                1435                1440
Asn Leu Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile Phe Gly Ser
                1445                1450                1455    
Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn Phe Asn
            1460                1465                1470        
Gln Gln Lys Lys Lys Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu
        1475                1480                1485            
Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro
    1490                1495                1500                
Gln Lys Pro Ile Pro Arg Pro Ala Asn Lys Phe Gln Gly Met Val Phe
1505                1510                1515                1520
Asp Phe Val Thr Arg Gln Val Phe Asp Ile Ser Ile Met Ile Leu Ile
                1525                1530                1535    
Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln Gly Lys
            1540                1545                1550        
Tyr Met Thr Leu Val Leu Ser Arg Ile Asn Leu Val Phe Ile Val Leu
        1555                1560                1565            
Phe Thr Gly Glu Phe Val Leu Lys Leu Val Ser Leu Arg His Tyr Tyr
    1570                1575                1580                
Phe Thr Ile Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu Ser
1585                1590                1595                1600
Ile Val Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr Phe Val Ser
                1605                1610                1615    
Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu
            1620                1625                1630        
Arg Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu
        1635                1640                1645            
Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu
    1650                1655                1660                
Val Met Phe Ile Tyr Ala Ile Phe Gly Met Ser Asn Phe Ala Tyr Val
1665                1670                1675                1680
Lys Lys Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Glu Thr Phe Gly
                1685                1690                1695    
Asn Ser Met Ile Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp
            1700                1705                1710        
Gly Leu Leu Ala Pro Ile Leu Asn Ser Ala Pro Pro Asp Cys Asp Pro
        1715                1720                1725            
Asp Thr Ile His Pro Gly Ser Ser Val Lys Gly Asp Cys Gly Asn Pro
    1730                1735                1740                
Ser Val Gly Ile Phe Phe Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu
1745                1750                1755                1760
Val Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Ser Val
                1765                1770                1775    
Ala Thr Glu Glu Ser Ala Glu Pro Leu Ser Glu Asp Asp Phe Glu Met
            1780                1785                1790        
Phe Tyr Glu Val Trp Glu Lys Phe Asp Pro Asp Ala Thr Gln Phe Ile
        1795                1800                1805            
Glu Phe Ser Lys Leu Ser Asp Phe Ala Ala Ala Leu Asp Pro Pro Leu
    1810                1815                1820                
Leu Ile Ala Lys Pro Asn Lys Val Gln Leu Ile Ala Met Asp Leu Pro
1825                1830                1835                1840
Met Val Ser Gly Asp Arg Ile His Cys Leu Asp Ile Leu Phe Ala Phe
                1845                1850                1855    
Thr Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Arg Ile
            1860                1865                1870        
Gln Met Glu Asp Arg Phe Met Ala Ser Asn Pro Ser Lys Val Ser Tyr
        1875                1880                1885            
Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu Glu Val Ser Ala
    1890                1895                1900                
Ala Ile Ile Gln Arg Asn Phe Arg Cys Tyr Leu Leu Lys Gln Arg Leu
1905                1910                1915                1920
Lys Asn Ile Ser Ser Asn Tyr Asn Lys Glu Ala Ile Lys Gly Arg Ile
                1925                1930                1935    
Asp Leu Pro Ile Lys Gln Asp Met Ile Ile Asp Lys Leu Asn Gly Asn
            1940                1945                1950        
Ser Thr Pro Glu Lys Thr Asp Gly Ser Ser Ser Thr Thr Ser Pro Pro
        1955                1960                1965            
Ser Tyr Asp Ser Val Thr Lys Pro Asp Lys Glu Lys Phe Glu Lys Asp
    1970                1975                1980                
Lys Pro Glu Lys Glu Ser Lys Gly Lys Glu Val Arg Glu Asn Gln Lys
1985                1990                1995                2000


<210> 9239
<211> 644
<212> PRT
<213> Homo sapiens

<400> 9239
Met Arg Pro Ser Gly Asp Glu Asp Arg Ala Arg Arg Arg Arg Arg Arg
 1               5                  10                  15      
Arg Arg Arg Arg Asp Leu Leu Leu Ser Gln Leu Cys Phe Leu Ala Ser
            20                  25                  30          
Val Ala Leu Leu Leu Trp Ser Leu Ser Ser Leu Arg Glu Gln Lys Glu
        35                  40                  45              
Leu Asp Leu Met Asp Leu Ile Gly Glu Asp Arg Lys Trp Met Met Ala
    50                  55                  60                  
Arg Lys Leu Met Gln Val Asn Asp Thr Leu Thr Ser Glu Asp Ala Gly
65                  70                  75                  80  
Leu Arg Asn Ser Lys Asn Cys Thr Glu Pro Ala Leu His Glu Phe Pro
                85                  90                  95      
Asn Asp Ile Phe Thr Asn Glu Asp Arg Arg Gln Gly Ala Val Val Leu
            100                 105                 110         
His Val Leu Cys Ala Ile Tyr Met Phe Tyr Ala Leu Ala Ile Val Cys
        115                 120                 125             
Asp Asp Phe Phe Val Pro Ser Leu Glu Lys Ile Cys Glu Arg Leu His
    130                 135                 140                 
Leu Ser Glu Asp Val Ala Gly Ala Thr Phe Met Ala Ala Gly Ser Ser
145                 150                 155                 160 
Ala Pro Glu Leu Phe Thr Ser Val Ile Gly Val Phe Ile Thr Lys Gly
                165                 170                 175     
Asp Val Gly Val Gly Thr Ile Val Gly Ser Ala Val Phe Asn Ile Leu
            180                 185                 190         
Cys Ile Ile Gly Val Cys Gly Leu Phe Ala Gly Gln Val Val Ala Leu
        195                 200                 205             
Ser Ser Trp Cys Leu Leu Arg Asp Ser Ile Tyr Tyr Thr Leu Ser Val
    210                 215                 220                 
Ile Ala Leu Ile Val Phe Ile Tyr Asp Glu Lys Val Ser Trp Trp Glu
225                 230                 235                 240 
Ser Leu Val Leu Val Leu Met Tyr Leu Ile Tyr Ile Val Ile Met Lys
                245                 250                 255     
Tyr Asn Ala Cys Ile His Gln Cys Phe Glu Arg Arg Thr Lys Gly Ala
            260                 265                 270         
Gly Asn Met Val Asn Gly Leu Ala Asn Asn Ala Glu Ile Asp Asp Ser
        275                 280                 285             
Ser Asn Cys Asp Ala Thr Val Val Leu Leu Lys Lys Ala Asn Phe His
    290                 295                 300                 
Arg Lys Ala Ser Val Ile Met Val Asp Glu Leu Leu Ser Ala Tyr Pro
305                 310                 315                 320 
His Gln Leu Ser Phe Ser Glu Ala Gly Leu Arg Ile Met Ile Thr Ser
                325                 330                 335     
His Phe Pro Pro Lys Thr Arg Leu Ser Met Ala Ser Arg Met Leu Ile
            340                 345                 350         
Asn Glu Arg Gln Arg Leu Ile Asn Ser Arg Ala Tyr Thr Asn Gly Glu
        355                 360                 365             
Ser Glu Val Ala Ile Lys Ile Pro Ile Lys His Thr Val Glu Asn Gly
    370                 375                 380                 
Thr Gly Pro Ser Ser Ala Pro Asp Arg Gly Val Asn Gly Thr Arg Arg
385                 390                 395                 400 
Asp Asp Val Val Ala Glu Ala Gly Asn Glu Thr Glu Asn Glu Asn Glu
                405                 410                 415     
Asp Asn Glu Asn Asp Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Glu
            420                 425                 430         
Gly Pro Tyr Thr Pro Phe Asp Thr Pro Ser Gly Lys Leu Glu Thr Val
        435                 440                 445             
Lys Trp Ala Phe Thr Trp Pro Leu Ser Phe Val Leu Tyr Phe Thr Val
    450                 455                 460                 
Pro Asn Cys Asn Lys Pro Arg Trp Glu Lys Trp Phe Met Val Thr Phe
465                 470                 475                 480 
Ala Ser Ser Thr Leu Trp Ile Ala Ala Phe Ser Tyr Met Met Val Trp
                485                 490                 495     
Met Val Thr Ile Ile Gly Tyr Thr Leu Gly Ile Pro Asp Val Ile Met
            500                 505                 510         
Gly Ile Thr Phe Leu Ala Ala Gly Thr Ser Val Pro Asp Cys Met Ala
        515                 520                 525             
Ser Leu Ile Val Ala Arg Gln Gly Met Gly Asp Met Ala Val Ser Asn
    530                 535                 540                 
Ser Ile Gly Ser Asn Val Phe Asp Ile Leu Ile Gly Leu Gly Leu Pro
545                 550                 555                 560 
Trp Ala Leu Gln Thr Leu Ala Val Asp Tyr Gly Ser Tyr Ile Arg Leu
                565                 570                 575     
Asn Ser Arg Gly Leu Ile Tyr Ser Val Gly Leu Leu Leu Ala Ser Val
            580                 585                 590         
Phe Val Thr Val Phe Gly Val His Leu Asn Lys Trp Gln Leu Asp Lys
        595                 600                 605             
Lys Leu Gly Cys Gly Cys Leu Leu Leu Tyr Gly Val Phe Leu Cys Phe
    610                 615                 620                 
Ser Ile Met Thr Glu Phe Asn Val Phe Thr Phe Val Asn Leu Pro Met
625                 630                 635                 640 
Cys Gly Asp His
                


<210> 9240
<211> 603
<212> PRT
<213> Homo sapiens

<400> 9240
Met Arg Pro Ser Gly Asp Glu Asp Arg Ala Arg Arg Arg Arg Arg Arg
 1               5                  10                  15      
Arg Arg Arg Arg Asp Leu Leu Leu Ser Gln Leu Cys Phe Leu Ala Ser
            20                  25                  30          
Val Ala Leu Leu Leu Trp Ser Leu Ser Ser Leu Arg Glu Gln Lys Glu
        35                  40                  45              
Leu Asp Leu Met Asp Leu Ile Gly Glu Asp Arg Lys Trp Met Met Ala
    50                  55                  60                  
Arg Lys Leu Met Gln Val Asn Asp Thr Leu Thr Ser Glu Asp Ala Gly
65                  70                  75                  80  
Leu Arg Asn Ser Lys Asn Cys Thr Glu Pro Ala Leu His Glu Phe Pro
                85                  90                  95      
Asn Asp Ile Phe Thr Asn Glu Asp Arg Arg Gln Gly Ala Val Val Leu
            100                 105                 110         
His Val Leu Cys Ala Ile Tyr Met Phe Tyr Ala Leu Ala Ile Val Cys
        115                 120                 125             
Asp Asp Phe Phe Val Pro Ser Leu Glu Lys Ile Cys Glu Arg Leu His
    130                 135                 140                 
Leu Ser Glu Asp Val Ala Gly Ala Thr Phe Met Ala Ala Gly Ser Ser
145                 150                 155                 160 
Ala Pro Glu Leu Phe Thr Ser Val Ile Gly Val Phe Ile Thr Lys Gly
                165                 170                 175     
Asp Val Gly Val Gly Thr Ile Val Gly Ser Ala Val Phe Asn Ile Leu
            180                 185                 190         
Cys Ile Ile Gly Val Cys Gly Leu Phe Ala Gly Gln Val Val Ala Leu
        195                 200                 205             
Ser Ser Trp Cys Leu Leu Arg Asp Ser Ile Tyr Tyr Thr Leu Ser Val
    210                 215                 220                 
Ile Ala Leu Ile Val Phe Ile Tyr Asp Glu Lys Val Ser Trp Trp Glu
225                 230                 235                 240 
Ser Leu Val Leu Val Leu Met Tyr Leu Ile Tyr Ile Val Ile Met Lys
                245                 250                 255     
Tyr Asn Ala Cys Ile His Gln Cys Phe Glu Arg Arg Thr Lys Gly Ala
            260                 265                 270         
Gly Asn Met Val Asn Gly Leu Ala Asn Asn Ala Glu Ile Asp Asp Ser
        275                 280                 285             
Ser Asn Cys Asp Ala Thr Val Val Leu Leu Lys Lys Ala Asn Phe His
    290                 295                 300                 
Arg Lys Ala Ser Val Ile Met Val Asp Glu Leu Leu Ser Ala Tyr Pro
305                 310                 315                 320 
His Gln Leu Ser Phe Ser Glu Ala Gly Leu Arg Ile Met Ile Thr Ser
                325                 330                 335     
His Phe Pro Pro Lys Thr Arg Leu Ser Met Ala Ser Arg Met Leu Ile
            340                 345                 350         
Asn Glu Arg Gln Arg Leu Ile Asn Ser Arg Ala Tyr Thr Asn Gly Glu
        355                 360                 365             
Ser Glu Val Ala Ile Lys Ile Pro Ile Lys His Thr Val Glu Asn Gly
    370                 375                 380                 
Thr Gly Pro Ser Ser Ala Pro Asp Arg Gly Val Asn Gly Thr Arg Arg
385                 390                 395                 400 
Ala Gly Lys Leu Glu Thr Val Lys Trp Ala Phe Thr Trp Pro Leu Ser
                405                 410                 415     
Phe Val Leu Tyr Phe Thr Val Pro Asn Cys Asn Lys Pro Arg Trp Glu
            420                 425                 430         
Lys Trp Phe Met Val Thr Phe Ala Ser Ser Thr Leu Trp Ile Ala Ala
        435                 440                 445             
Phe Ser Tyr Met Met Val Trp Met Val Thr Ile Ile Gly Tyr Thr Leu
    450                 455                 460                 
Gly Ile Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala Gly Thr
465                 470                 475                 480 
Ser Val Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln Gly Met
                485                 490                 495     
Gly Asp Met Ala Val Ser Asn Ser Ile Gly Ser Asn Val Phe Asp Ile
            500                 505                 510         
Leu Ile Gly Leu Gly Leu Pro Trp Ala Leu Gln Thr Leu Ala Val Asp
        515                 520                 525             
Tyr Gly Ser Tyr Ile Arg Leu Asn Ser Arg Gly Leu Ile Tyr Ser Val
    530                 535                 540                 
Gly Leu Leu Leu Ala Ser Val Phe Val Thr Val Phe Gly Val His Leu
545                 550                 555                 560 
Asn Lys Trp Gln Leu Asp Lys Lys Leu Gly Cys Gly Cys Leu Leu Leu
                565                 570                 575     
Tyr Gly Val Phe Leu Cys Phe Ser Ile Met Thr Glu Phe Asn Val Phe
            580                 585                 590         
Thr Phe Val Asn Leu Pro Met Cys Gly Asp His
        595                 600             


<210> 9241
<211> 344
<212> PRT
<213> Homo sapiens

<400> 9241
Met Arg Pro Thr Leu Leu Trp Ser Leu Leu Leu Leu Leu Gly Val Phe
 1               5                  10                  15      
Ala Ala Ala Ala Ala Ala Pro Pro Asp Pro Leu Ser Gln Leu Pro Ala
            20                  25                  30          
Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala Glu Gln Val Leu Ser
        35                  40                  45              
Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg Pro Val Val Tyr Gln
    50                  55                  60                  
Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe Thr Ala Asp Ile Met
65                  70                  75                  80  
Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala Thr Glu Cys Asp Phe
                85                  90                  95      
Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met Asp Phe Asn Val Thr
            100                 105                 110         
Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His Ser Ala Trp Val Thr
        115                 120                 125             
Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr Val Gly Pro Pro Glu
    130                 135                 140                 
Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu Ile Ile Arg Phe Ser
145                 150                 155                 160 
Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala Phe Phe Cys Tyr Tyr
                165                 170                 175     
Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln Ala Arg Ala Ser Phe
            180                 185                 190         
Phe Phe Val Lys Gly Pro Phe Arg Ser Asn Ser Ile Ser Leu Asp Asn
        195                 200                 205             
Leu Lys Pro Ser Arg Val Tyr Cys Leu Gln Val Gln Ala Gln Leu Leu
    210                 215                 220                 
Trp Asn Lys Ser Asn Ile Phe Arg Val Gly His Leu Ser Asn Ile Ser
225                 230                 235                 240 
Cys Tyr Glu Thr Met Ala Asp Ala Ser Thr Glu Leu Gln Gln Val Ile
                245                 250                 255     
Leu Ile Ser Val Gly Thr Phe Ser Leu Leu Ser Val Leu Ala Gly Ala
            260                 265                 270         
Cys Phe Phe Leu Val Leu Lys Tyr Arg Gly Leu Ile Lys Tyr Trp Phe
        275                 280                 285             
His Thr Pro Pro Ser Ile Pro Leu Gln Ile Glu Glu Tyr Leu Lys Asp
    290                 295                 300                 
Pro Thr Gln Pro Ile Leu Glu Ala Leu Asp Lys Asp Ser Ser Pro Lys
305                 310                 315                 320 
Asp Asp Val Trp Asp Ser Val Ser Ile Ile Ser Phe Pro Glu Lys Glu
                325                 330                 335     
Gln Glu Asp Val Leu Gln Thr Leu
            340                 


<210> 9242
<211> 427
<212> PRT
<213> Homo sapiens

<400> 9242
Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys
 1               5                  10                  15      
Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln
            20                  25                  30          
Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val
        35                  40                  45              
Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu
    50                  55                  60                  
Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro
65                  70                  75                  80  
Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu
                85                  90                  95      
Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile
            100                 105                 110         
Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala
        115                 120                 125             
Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys
    130                 135                 140                 
Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu
145                 150                 155                 160 
Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile
                165                 170                 175     
Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val
            180                 185                 190         
Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp
        195                 200                 205             
Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser
    210                 215                 220                 
Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn
225                 230                 235                 240 
Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg
                245                 250                 255     
Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His
            260                 265                 270         
Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu
        275                 280                 285             
Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro
    290                 295                 300                 
Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys
305                 310                 315                 320 
Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile
                325                 330                 335     
Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val
            340                 345                 350         
Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys
        355                 360                 365             
Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile
    370                 375                 380                 
Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys
385                 390                 395                 400 
Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val
                405                 410                 415     
Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln
            420                 425         


<210> 9243
<211> 668
<212> PRT
<213> Homo sapiens

<400> 9243
Met His Trp Tyr Arg Arg Val Pro Ile Arg Val Ser Ser Ser Glu Ser
 1               5                  10                  15      
Asp Ser Ser Pro Ala Leu Gly Pro Arg Ser Pro Gln Gln Asp Arg Gln
            20                  25                  30          
Val Trp His Thr Tyr Gly Gln Ser Lys Gly Phe Arg Ala Pro Glu Ala
        35                  40                  45              
Phe Lys Glu Val Ala Leu Glu Leu Val Thr Arg His Lys Leu His Ser
    50                  55                  60                  
Ser Cys Gln Leu Ser Glu Pro Arg Arg Arg Thr Arg Arg Ser Glu Leu
65                  70                  75                  80  
Ser Gly Gly Ser Ala Ala Ala Gly Ala Gly Ala Gln Glu Pro Thr Gly
                85                  90                  95      
Pro Asp Gln Asp Gly Ala Val Ala Ala Pro Arg Arg Thr His Ala Leu
            100                 105                 110         
Ser Gly Pro Ser Leu Gly Pro Ala Pro Pro Ala Pro Pro Ala Ala Pro
        115                 120                 125             
Ile Arg Ala Gly Met Met Cys Leu Glu Cys Ala Ser Ala Ala Ala Gly
    130                 135                 140                 
Gly Ala Glu Glu Glu Glu Ala Asp Ala Glu Arg Arg Arg Arg Arg Arg
145                 150                 155                 160 
Gly Ala Gln Arg Gly Ala Gly Gly Ser Gly Cys Cys Gly Ala Arg Gly
                165                 170                 175     
Ala Gly Gly Ala Gly Val Ser Ala Ala Gly Asp Glu Val Gln Thr Leu
            180                 185                 190         
Ser Gly Ser Val Arg Arg Ala Pro Thr Gly Pro Pro Gly Thr Pro Gly
        195                 200                 205             
Thr Pro Gly Cys Ala Ala Thr Ala Lys Gly Pro Gly Ala Gln Gln Pro
    210                 215                 220                 
Lys Pro Ala Ser Leu Gly Arg Gly Arg Gly Ala Ala Ala Ala Ile Leu
225                 230                 235                 240 
Ser Leu Gly Asn Val Leu Asn Tyr Leu Asp Arg Tyr Thr Val Ala Gly
                245                 250                 255     
Val Leu Leu Asp Ile Gln Gln His Phe Gly Val Lys Asp Arg Gly Ala
            260                 265                 270         
Gly Leu Leu Gln Ser Val Phe Ile Cys Ser Phe Met Val Ala Ala Pro
        275                 280                 285             
Ile Phe Gly Tyr Leu Gly Asp Arg Phe Asn Arg Lys Val Ile Leu Ser
    290                 295                 300                 
Cys Gly Ile Phe Phe Trp Ser Ala Val Thr Phe Ser Ser Ser Phe Ile
305                 310                 315                 320 
Pro Gln Gln Tyr Phe Trp Leu Leu Val Leu Ser Arg Gly Leu Val Gly
                325                 330                 335     
Ile Gly Glu Ala Ser Tyr Ser Thr Ile Ala Pro Thr Ile Ile Gly Asp
            340                 345                 350         
Leu Phe Thr Lys Asn Thr Arg Thr Leu Met Leu Ser Val Phe Tyr Phe
        355                 360                 365             
Ala Ile Pro Leu Gly Ser Gly Leu Gly Tyr Ile Thr Gly Ser Ser Val
    370                 375                 380                 
Lys Gln Ala Ala Gly Asp Trp His Trp Ala Leu Arg Val Ser Pro Val
385                 390                 395                 400 
Leu Gly Met Ile Thr Gly Thr Leu Ile Leu Ile Leu Val Pro Ala Thr
                405                 410                 415     
Lys Arg Gly His Ala Asp Gln Leu Gly Asp Gln Leu Lys Ala Arg Thr
            420                 425                 430         
Ser Trp Leu Arg Asp Met Lys Ala Leu Ile Arg Asn Arg Ser Tyr Val
        435                 440                 445             
Phe Ser Ser Leu Ala Thr Ser Ala Val Ser Phe Ala Thr Gly Ala Leu
    450                 455                 460                 
Gly Met Trp Ile Pro Leu Tyr Leu His Arg Ala Gln Val Val Gln Lys
465                 470                 475                 480 
Thr Ala Glu Thr Cys Asn Ser Pro Pro Cys Gly Ala Lys Asp Ser Leu
                485                 490                 495     
Ile Phe Gly Ala Ile Thr Cys Phe Thr Gly Phe Leu Gly Val Val Thr
            500                 505                 510         
Gly Ala Gly Ala Thr Arg Trp Cys Arg Leu Lys Thr Gln Arg Ala Asp
        515                 520                 525             
Pro Leu Val Cys Ala Val Gly Met Leu Gly Ser Ala Ile Phe Ile Cys
    530                 535                 540                 
Leu Ile Phe Val Ala Ala Lys Ser Ser Ile Val Gly Ala Tyr Ile Cys
545                 550                 555                 560 
Ile Phe Val Gly Glu Thr Leu Leu Phe Ser Asn Trp Ala Ile Thr Ala
                565                 570                 575     
Asp Ile Leu Met Tyr Val Val Ile Pro Thr Arg Arg Ala Thr Ala Val
            580                 585                 590         
Ala Leu Gln Ser Phe Thr Ser His Leu Leu Gly Asp Ala Gly Ser Pro
        595                 600                 605             
Tyr Leu Ile Gly Phe Ile Ser Asp Leu Ile Arg Gln Ser Thr Lys Asp
    610                 615                 620                 
Ser Pro Leu Trp Glu Phe Leu Ser Leu Gly Tyr Ala Leu Met Leu Cys
625                 630                 635                 640 
Pro Phe Val Val Val Leu Gly Gly Met Phe Phe Leu Ala Thr Ala Leu
                645                 650                 655     
Phe Phe Val Ser Asp Arg Ala Arg Ala Glu Gln Gln
            660                 665             


<210> 9244
<211> 491
<212> PRT
<213> Homo sapiens

<400> 9244
Met Ile Ala Thr Gly Gly Val Ile Thr Gly Leu Ala Ala Leu Lys Arg
 1               5                  10                  15      
Gln Asp Ser Ala Arg Ser Gln Gln His Val Asn Leu Ser Pro Ser Pro
            20                  25                  30          
Ala Thr Gln Glu Lys Lys Pro Ile Arg Arg Arg Pro Arg Ala Asp Val
        35                  40                  45              
Val Val Val Arg Gly Lys Ile Arg Leu Tyr Ser Pro Ser Gly Phe Phe
    50                  55                  60                  
Leu Ile Leu Gly Val Leu Ile Ser Ile Ile Gly Ile Ala Met Ala Val
65                  70                  75                  80  
Leu Gly Tyr Trp Pro Gln Lys Glu His Phe Ile Asp Ala Glu Thr Thr
                85                  90                  95      
Leu Ser Thr Asn Glu Thr Gln Val Ile Arg Asn Glu Gly Gly Val Val
            100                 105                 110         
Val Arg Phe Phe Glu Gln His Leu His Ser Asp Lys Met Lys Met Leu
        115                 120                 125             
Gly Pro Phe Thr Met Gly Ile Gly Ile Phe Ile Phe Ile Cys Ala Asn
    130                 135                 140                 
Ala Ile Leu His Glu Asn Arg Asp Lys Glu Thr Lys Ile Ile His Met
145                 150                 155                 160 
Arg Asp Ile Tyr Ser Thr Val Ile Asp Ile His Thr Leu Arg Ile Lys
                165                 170                 175     
Glu Gln Arg Gln Met Asn Gly Met Tyr Thr Gly Leu Met Gly Glu Thr
            180                 185                 190         
Glu Val Lys Gln Asn Gly Ser Ser Cys Ala Ser Arg Leu Ala Ala Asn
        195                 200                 205             
Thr Ile Ala Ser Phe Ser Gly Phe Arg Ser Ser Phe Arg Met Asp Ser
    210                 215                 220                 
Ser Val Glu Glu Asp Glu Leu Met Leu Asn Glu Gly Lys Ser Ser Gly
225                 230                 235                 240 
His Leu Met Pro Pro Leu Leu Ser Asp Ser Ser Val Ser Val Phe Gly
                245                 250                 255     
Leu Tyr Pro Pro Pro Ser Lys Thr Thr Asp Asp Lys Thr Ser Gly Ser
            260                 265                 270         
Lys Lys Cys Glu Thr Lys Ser Ile Val Ser Ser Ser Ile Ser Ala Phe
        275                 280                 285             
Thr Leu Pro Val Ile Lys Leu Asn Asn Cys Val Ile Asp Glu Pro Ser
    290                 295                 300                 
Ile Asp Asn Ile Thr Glu Asp Ala Asp Asn Leu Lys Ser Arg Ser Arg
305                 310                 315                 320 
Asn Leu Ser Met Asp Ser Leu Val Val Pro Leu Pro Asn Thr Ser Glu
                325                 330                 335     
Ser Phe Gln Pro Val Ser Thr Val Leu Pro Arg Asn Asn Ser Ile Gly
            340                 345                 350         
Glu Ser Leu Ser Ser Gln Tyr Lys Ser Ser Met Ala Leu Gly Pro Gly
        355                 360                 365             
Ala Gly Gln Leu Leu Ser Pro Gly Ala Ala Arg Arg Gln Phe Gly Ser
    370                 375                 380                 
Asn Thr Ser Leu His Leu Leu Ser Ser His Ser Lys Ser Leu Asp Leu
385                 390                 395                 400 
Asp Arg Gly Pro Ser Thr Leu Thr Val Gln Ala Glu Gln Arg Lys His
                405                 410                 415     
Pro Ser Trp Pro Arg Leu Asp Arg Asn Asn Ser Lys Gly Tyr Met Lys
            420                 425                 430         
Leu Glu Asn Lys Glu Asp Pro Met Asp Arg Leu Leu Val Pro Gln Val
        435                 440                 445             
Ala Ile Lys Lys Asp Phe Thr Asn Lys Glu Lys Leu Leu Met Ile Ser
    450                 455                 460                 
Arg Ser His Asn Asn Leu Ser Phe Glu His Asp Glu Phe Leu Ser Asn
465                 470                 475                 480 
Asn Leu Lys Arg Gly Thr Ser Glu Thr Arg Phe
                485                 490     


<210> 9245
<211> 509
<212> PRT
<213> Homo sapiens

<400> 9245
Arg Glu Gln Gly Ile Ser Trp Asp Ile Trp Leu Trp Arg Val Lys Gly
 1               5                  10                  15      
Gln Ala Met Ile Ala Thr Gly Gly Val Ile Thr Gly Leu Ala Ala Leu
            20                  25                  30          
Lys Arg Gln Asp Ser Ala Arg Ser Gln Gln His Val Asn Leu Ser Pro
        35                  40                  45              
Ser Pro Ala Thr Gln Glu Lys Lys Pro Ile Arg Arg Arg Pro Arg Ala
    50                  55                  60                  
Asp Val Val Val Val Arg Gly Lys Ile Arg Leu Tyr Ser Pro Ser Gly
65                  70                  75                  80  
Phe Phe Leu Ile Leu Gly Val Leu Ile Ser Ile Ile Gly Ile Ala Met
                85                  90                  95      
Ala Val Leu Gly Tyr Trp Pro Gln Lys Glu His Phe Ile Asp Ala Glu
            100                 105                 110         
Thr Thr Leu Ser Thr Asn Glu Thr Gln Val Ile Arg Asn Glu Gly Gly
        115                 120                 125             
Val Val Val Arg Phe Phe Glu Gln His Leu His Ser Asp Lys Met Lys
    130                 135                 140                 
Met Leu Gly Pro Phe Thr Met Gly Ile Gly Ile Phe Ile Phe Ile Cys
145                 150                 155                 160 
Ala Asn Ala Ile Leu His Glu Asn Arg Asp Lys Glu Thr Lys Ile Ile
                165                 170                 175     
His Met Arg Asp Ile Tyr Ser Thr Val Ile Asp Ile His Thr Leu Arg
            180                 185                 190         
Ile Lys Glu Gln Arg Gln Met Asn Gly Met Tyr Thr Gly Leu Met Gly
        195                 200                 205             
Glu Thr Glu Val Lys Gln Asn Gly Ser Ser Cys Ala Ser Arg Leu Ala
    210                 215                 220                 
Ala Asn Thr Ile Ala Ser Phe Ser Gly Phe Arg Ser Ser Phe Arg Met
225                 230                 235                 240 
Asp Ser Ser Val Glu Glu Asp Glu Leu Met Leu Asn Glu Gly Lys Ser
                245                 250                 255     
Ser Gly His Leu Met Pro Pro Leu Leu Ser Asp Ser Ser Val Ser Val
            260                 265                 270         
Phe Gly Leu Tyr Pro Pro Pro Ser Lys Thr Thr Asp Asp Lys Thr Ser
        275                 280                 285             
Gly Ser Lys Lys Cys Glu Thr Lys Ser Ile Val Ser Ser Ser Ile Ser
    290                 295                 300                 
Ala Phe Thr Leu Pro Val Ile Lys Leu Asn Asn Cys Val Ile Asp Glu
305                 310                 315                 320 
Pro Ser Ile Asp Asn Ile Thr Glu Asp Ala Asp Asn Leu Lys Ser Arg
                325                 330                 335     
Ser Arg Asn Leu Ser Met Asp Ser Leu Val Val Pro Leu Pro Asn Thr
            340                 345                 350         
Ser Glu Ser Phe Gln Pro Val Ser Thr Val Leu Pro Arg Asn Asn Ser
        355                 360                 365             
Ile Gly Glu Ser Leu Ser Ser Gln Tyr Lys Ser Ser Met Ala Leu Gly
    370                 375                 380                 
Pro Gly Ala Gly Gln Leu Leu Ser Pro Gly Ala Ala Arg Arg Gln Phe
385                 390                 395                 400 
Gly Ser Asn Thr Ser Leu His Leu Leu Ser Ser His Ser Lys Ser Leu
                405                 410                 415     
Asp Leu Asp Arg Gly Pro Ser Thr Leu Thr Val Gln Ala Glu Gln Arg
            420                 425                 430         
Lys His Pro Ser Trp Pro Arg Leu Asp Arg Asn Asn Ser Lys Gly Tyr
        435                 440                 445             
Met Lys Leu Glu Asn Lys Glu Asp Pro Met Asp Arg Leu Leu Val Pro
    450                 455                 460                 
Gln Val Ala Ile Lys Lys Asp Phe Thr Asn Lys Glu Lys Leu Leu Met
465                 470                 475                 480 
Ile Ser Arg Ser His Asn Asn Leu Ser Phe Glu His Asp Glu Phe Leu
                485                 490                 495     
Ser Asn Asn Leu Lys Arg Gly Thr Ser Glu Thr Arg Phe
            500                 505                 


<210> 9246
<211> 3014
<212> PRT
<213> Homo sapiens

<400> 9246
Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala
 1               5                  10                  15      
Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu
            20                  25                  30          
Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys
        35                  40                  45              
Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu
    50                  55                  60                  
Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser
65                  70                  75                  80  
Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser
                85                  90                  95      
Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro
            100                 105                 110         
Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys
        115                 120                 125             
Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His
    130                 135                 140                 
Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro
145                 150                 155                 160 
Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly
                165                 170                 175     
Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly
            180                 185                 190         
Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro
        195                 200                 205             
Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu
    210                 215                 220                 
Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg
225                 230                 235                 240 
Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu
                245                 250                 255     
Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr
            260                 265                 270         
Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe
        275                 280                 285             
Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala
    290                 295                 300                 
Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val
305                 310                 315                 320 
Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr
                325                 330                 335     
Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val
            340                 345                 350         
Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val
        355                 360                 365             
Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile
    370                 375                 380                 
Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe
385                 390                 395                 400 
Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp
                405                 410                 415     
Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln
            420                 425                 430         
Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu
        435                 440                 445             
Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr
    450                 455                 460                 
Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg
465                 470                 475                 480 
Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr
                485                 490                 495     
Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu
            500                 505                 510         
Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln
        515                 520                 525             
Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu
    530                 535                 540                 
Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp
545                 550                 555                 560 
Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu
                565                 570                 575     
Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala
            580                 585                 590         
Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala
        595                 600                 605             
Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro
    610                 615                 620                 
Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr
625                 630                 635                 640 
Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly
                645                 650                 655     
Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser
            660                 665                 670         
Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr
        675                 680                 685             
Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser
    690                 695                 700                 
Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile
705                 710                 715                 720 
Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser
                725                 730                 735     
Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr
            740                 745                 750         
Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr
        755                 760                 765             
Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr
    770                 775                 780                 
His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu
785                 790                 795                 800 
Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu
                805                 810                 815     
Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val
            820                 825                 830         
Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met
        835                 840                 845             
Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala
    850                 855                 860                 
Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile
865                 870                 875                 880 
Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe
                885                 890                 895     
Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu
            900                 905                 910         
Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu
        915                 920                 925             
Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu
    930                 935                 940                 
Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn
945                 950                 955                 960 
Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro
                965                 970                 975     
Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile
            980                 985                 990         
Asn Asp Asn Ala Pro Met Phe Glu Lys Asp Glu Leu Glu Leu Phe Val
        995                 1000                1005            
Glu Glu Asn Asn Pro Val Gly Ser Val Val Ala Lys Ile Arg Ala Asn
    1010                1015                1020                
Asp Pro Asp Glu Gly Pro Asn Ala Gln Ile Met Tyr Gln Ile Val Glu
1025                1030                1035                1040
Gly Asp Met Arg His Phe Phe Gln Leu Asp Leu Leu Asn Gly Asp Leu
                1045                1050                1055    
Arg Ala Met Val Glu Leu Asp Phe Glu Val Arg Arg Glu Tyr Val Leu
            1060                1065                1070        
Val Val Gln Ala Thr Ser Ala Pro Leu Val Ser Arg Ala Thr Val His
        1075                1080                1085            
Ile Leu Leu Val Asp Gln Asn Asp Asn Pro Pro Val Leu Pro Asp Phe
    1090                1095                1100                
Gln Ile Leu Phe Asn Asn Tyr Val Thr Asn Lys Ser Asn Ser Phe Pro
1105                1110                1115                1120
Thr Gly Val Ile Gly Cys Ile Pro Ala His Asp Pro Asp Val Ser Asp
                1125                1130                1135    
Ser Leu Asn Tyr Thr Phe Val Gln Gly Asn Glu Leu Arg Leu Leu Leu
            1140                1145                1150        
Leu Asp Pro Ala Thr Gly Glu Leu Gln Leu Ser Arg Asp Leu Asp Asn
        1155                1160                1165            
Asn Arg Pro Leu Glu Ala Leu Met Glu Val Ser Val Ser Asp Gly Ile
    1170                1175                1180                
His Ser Val Thr Ala Phe Cys Thr Leu Arg Val Thr Ile Ile Thr Asp
1185                1190                1195                1200
Asp Met Leu Thr Asn Ser Ile Thr Val Arg Leu Glu Asn Met Ser Gln
                1205                1210                1215    
Glu Lys Phe Leu Ser Pro Leu Leu Ala Leu Phe Val Glu Gly Val Ala
            1220                1225                1230        
Ala Val Leu Ser Thr Thr Lys Asp Asp Val Phe Val Phe Asn Val Gln
        1235                1240                1245            
Asn Asp Thr Asp Val Ser Ser Asn Ile Leu Asn Val Thr Phe Ser Ala
    1250                1255                1260                
Leu Leu Pro Gly Gly Val Arg Gly Gln Phe Phe Pro Ser Glu Asp Leu
1265                1270                1275                1280
Gln Glu Gln Ile Tyr Leu Asn Arg Thr Leu Leu Thr Thr Ile Ser Thr
                1285                1290                1295    
Gln Arg Val Leu Pro Phe Asp Asp Asn Ile Cys Leu Arg Glu Pro Cys
            1300                1305                1310        
Glu Asn Tyr Met Lys Cys Val Ser Val Leu Arg Phe Asp Ser Ser Ala
        1315                1320                1325            
Pro Phe Leu Ser Ser Thr Thr Val Leu Phe Arg Pro Ile His Pro Ile
    1330                1335                1340                
Asn Gly Leu Arg Cys Arg Cys Pro Pro Gly Phe Thr Gly Asp Tyr Cys
1345                1350                1355                1360
Glu Thr Glu Ile Asp Leu Cys Tyr Ser Asp Pro Cys Gly Ala Asn Gly
                1365                1370                1375    
Arg Cys Arg Ser Arg Glu Gly Gly Tyr Thr Cys Glu Cys Phe Glu Asp
            1380                1385                1390        
Phe Thr Gly Glu His Cys Glu Val Asp Ala Arg Ser Gly Arg Cys Ala
        1395                1400                1405            
Asn Gly Val Cys Lys Asn Gly Gly Thr Cys Val Asn Leu Leu Ile Gly
    1410                1415                1420                
Gly Phe His Cys Val Cys Pro Pro Gly Glu Tyr Glu Arg Pro Tyr Cys
1425                1430                1435                1440
Glu Val Thr Thr Arg Ser Phe Pro Pro Gln Ser Phe Val Thr Phe Arg
                1445                1450                1455    
Gly Leu Arg Gln Arg Phe His Phe Thr Ile Ser Leu Thr Phe Ala Thr
            1460                1465                1470        
Gln Glu Arg Asn Gly Leu Leu Leu Tyr Asn Gly Arg Phe Asn Glu Lys
        1475                1480                1485            
His Asp Phe Ile Ala Leu Glu Ile Val Asp Glu Gln Val Gln Leu Thr
    1490                1495                1500                
Phe Ser Ala Gly Glu Thr Thr Thr Thr Val Ala Pro Lys Val Pro Ser
1505                1510                1515                1520
Gly Val Ser Asp Gly Arg Trp His Ser Val Gln Val Gln Tyr Tyr Asn
                1525                1530                1535    
Lys Pro Asn Ile Gly His Leu Gly Leu Pro His Gly Pro Ser Gly Glu
            1540                1545                1550        
Lys Met Ala Val Val Thr Val Asp Asp Cys Asp Thr Thr Met Ala Val
        1555                1560                1565            
Arg Phe Gly Lys Asp Ile Gly Asn Tyr Ser Cys Ala Ala Gln Gly Thr
    1570                1575                1580                
Gln Thr Gly Ser Lys Lys Ser Leu Asp Leu Thr Gly Pro Leu Leu Leu
1585                1590                1595                1600
Gly Gly Val Pro Asn Leu Pro Glu Asp Phe Pro Val His Asn Arg Gln
                1605                1610                1615    
Phe Val Gly Cys Met Arg Asn Leu Ser Val Asp Gly Lys Asn Val Asp
            1620                1625                1630        
Met Ala Gly Phe Ile Ala Asn Asn Gly Thr Arg Glu Gly Cys Ala Ala
        1635                1640                1645            
Arg Arg Asn Phe Cys Asp Gly Arg Arg Cys Gln Asn Gly Gly Thr Cys
    1650                1655                1660                
Val Asn Arg Trp Asn Met Tyr Leu Cys Glu Cys Pro Leu Arg Phe Gly
1665                1670                1675                1680
Gly Lys Asn Cys Glu Gln Ala Met Pro His Pro Gln Leu Phe Ser Gly
                1685                1690                1695    
Glu Ser Val Val Ser Trp Ser Asp Leu Asn Ile Ile Ile Ser Val Pro
            1700                1705                1710        
Trp Tyr Leu Gly Leu Met Phe Arg Thr Arg Lys Glu Asp Ser Val Leu
        1715                1720                1725            
Met Glu Ala Thr Ser Gly Gly Pro Thr Ser Phe Arg Leu Gln Ile Leu
    1730                1735                1740                
Asn Asn Tyr Leu Gln Phe Glu Val Ser His Gly Pro Ser Asp Val Glu
1745                1750                1755                1760
Ser Val Met Leu Ser Gly Leu Arg Val Thr Asp Gly Glu Trp His His
                1765                1770                1775    
Leu Leu Ile Glu Leu Lys Asn Val Lys Glu Asp Ser Glu Met Lys His
            1780                1785                1790        
Leu Val Thr Met Thr Leu Asp Tyr Gly Met Asp Gln Asn Lys Ala Asp
        1795                1800                1805            
Ile Gly Gly Met Leu Pro Gly Leu Thr Val Arg Ser Val Val Val Gly
    1810                1815                1820                
Gly Ala Ser Glu Asp Lys Val Ser Val Arg Arg Gly Phe Arg Gly Cys
1825                1830                1835                1840
Met Gln Gly Val Arg Met Gly Gly Thr Pro Thr Asn Val Ala Thr Leu
                1845                1850                1855    
Asn Met Asn Asn Ala Leu Lys Val Arg Val Lys Asp Gly Cys Asp Val
            1860                1865                1870        
Asp Asp Pro Cys Thr Ser Ser Pro Cys Pro Pro Asn Ser Arg Cys His
        1875                1880                1885            
Asp Ala Trp Glu Asp Tyr Ser Cys Val Cys Asp Lys Gly Tyr Leu Gly
    1890                1895                1900                
Ile Asn Cys Val Asp Ala Cys His Leu Asn Pro Cys Glu Asn Met Gly
1905                1910                1915                1920
Ala Cys Val Arg Ser Pro Gly Ser Pro Gln Gly Tyr Val Cys Glu Cys
                1925                1930                1935    
Gly Pro Ser His Tyr Gly Pro Tyr Cys Glu Asn Lys Leu Asp Leu Pro
            1940                1945                1950        
Cys Pro Arg Gly Trp Trp Gly Asn Pro Val Cys Gly Pro Cys His Cys
        1955                1960                1965            
Ala Val Ser Lys Gly Phe Asp Pro Asp Cys Asn Lys Thr Asn Gly Gln
    1970                1975                1980                
Cys Gln Cys Lys Glu Asn Tyr Tyr Lys Leu Leu Ala Gln Asp Thr Cys
1985                1990                1995                2000
Leu Pro Cys Asp Cys Phe Pro His Gly Ser His Ser Arg Thr Cys Asp
                2005                2010                2015    
Met Ala Thr Gly Gln Cys Ala Cys Lys Pro Gly Val Ile Gly Arg Gln
            2020                2025                2030        
Cys Asn Arg Cys Asp Asn Pro Phe Ala Glu Val Thr Thr Leu Gly Cys
        2035                2040                2045            
Glu Val Ile Tyr Asn Gly Cys Pro Lys Ala Phe Glu Ala Gly Ile Trp
    2050                2055                2060                
Trp Pro Gln Thr Lys Phe Gly Gln Pro Ala Ala Val Pro Cys Pro Lys
2065                2070                2075                2080
Gly Ser Val Gly Asn Ala Val Arg His Cys Ser Gly Glu Lys Gly Trp
                2085                2090                2095    
Leu Pro Pro Glu Leu Phe Asn Cys Thr Thr Ile Ser Phe Val Asp Leu
            2100                2105                2110        
Arg Ala Met Asn Glu Lys Leu Ser Arg Asn Glu Thr Gln Val Asp Gly
        2115                2120                2125            
Ala Arg Ala Leu Gln Leu Val Arg Ala Leu Arg Ser Ala Thr Gln His
    2130                2135                2140                
Thr Gly Thr Leu Phe Gly Asn Asp Val Arg Thr Ala Tyr Gln Leu Leu
2145                2150                2155                2160
Gly His Val Leu Gln His Glu Ser Trp Gln Gln Gly Phe Asp Leu Ala
                2165                2170                2175    
Ala Thr Gln Asp Ala Asp Phe His Glu Asp Val Ile His Ser Gly Ser
            2180                2185                2190        
Ala Leu Leu Ala Pro Ala Thr Arg Ala Ala Trp Glu Gln Ile Gln Arg
        2195                2200                2205            
Ser Glu Gly Gly Thr Ala Gln Leu Leu Arg Arg Leu Glu Gly Tyr Phe
    2210                2215                2220                
Ser Asn Val Ala Arg Asn Val Arg Arg Thr Tyr Leu Arg Pro Phe Val
2225                2230                2235                2240
Ile Val Thr Ala Asn Met Ile Leu Ala Val Asp Ile Phe Asp Lys Phe
                2245                2250                2255    
Asn Phe Thr Gly Ala Arg Val Pro Arg Phe Asp Thr Ile His Glu Glu
            2260                2265                2270        
Phe Pro Arg Glu Leu Glu Ser Ser Val Ser Phe Pro Ala Asp Phe Phe
        2275                2280                2285            
Arg Pro Pro Glu Glu Lys Glu Gly Pro Leu Leu Arg Pro Ala Gly Arg
    2290                2295                2300                
Arg Thr Thr Pro Gln Thr Thr Arg Pro Gly Pro Gly Thr Glu Arg Glu
2305                2310                2315                2320
Ala Pro Ile Ser Arg Arg Arg Arg His Pro Asp Asp Ala Gly Gln Phe
                2325                2330                2335    
Ala Val Ala Leu Val Ile Ile Tyr Arg Thr Leu Gly Gln Leu Leu Pro
            2340                2345                2350        
Glu Arg Tyr Asp Pro Asp Arg Arg Ser Leu Arg Leu Pro His Arg Pro
        2355                2360                2365            
Ile Ile Asn Thr Pro Met Val Ser Thr Leu Val Tyr Ser Glu Gly Ala
    2370                2375                2380                
Pro Leu Pro Arg Pro Leu Glu Arg Pro Val Leu Val Glu Phe Ala Leu
2385                2390                2395                2400
Leu Glu Val Glu Glu Arg Thr Lys Pro Val Cys Val Phe Trp Asn His
                2405                2410                2415    
Ser Leu Ala Val Gly Gly Thr Gly Gly Trp Ser Ala Arg Gly Cys Glu
            2420                2425                2430        
Leu Leu Ser Arg Asn Arg Thr His Val Ala Cys Gln Cys Ser His Thr
        2435                2440                2445            
Ala Ser Phe Ala Val Leu Met Asp Ile Ser Arg Arg Glu Asn Gly Glu
    2450                2455                2460                
Val Leu Pro Leu Lys Ile Val Thr Tyr Ala Ala Val Ser Leu Ser Leu
2465                2470                2475                2480
Ala Ala Leu Leu Val Ala Phe Val Leu Leu Ser Leu Val Arg Met Leu
                2485                2490                2495    
Arg Ser Asn Leu His Ser Ile His Lys His Leu Ala Val Ala Leu Phe
            2500                2505                2510        
Leu Ser Gln Leu Val Phe Val Ile Gly Ile Asn Gln Thr Glu Asn Pro
        2515                2520                2525            
Phe Leu Cys Thr Val Val Ala Ile Leu Leu His Tyr Ile Tyr Met Ser
    2530                2535                2540                
Thr Phe Ala Trp Thr Leu Val Glu Ser Leu His Val Tyr Arg Met Leu
2545                2550                2555                2560
Thr Glu Val Arg Asn Ile Asp Thr Gly Pro Met Arg Phe Tyr Tyr Val
                2565                2570                2575    
Val Gly Trp Gly Ile Pro Ala Ile Val Thr Gly Leu Ala Val Gly Leu
            2580                2585                2590        
Asp Pro Gln Gly Tyr Gly Asn Pro Asp Phe Cys Trp Leu Ser Leu Gln
        2595                2600                2605            
Asp Thr Leu Ile Trp Ser Phe Ala Gly Pro Ile Gly Ala Val Ile Ile
    2610                2615                2620                
Ile Asn Thr Val Thr Ser Val Leu Ser Ala Lys Val Ser Cys Gln Arg
2625                2630                2635                2640
Lys His His Tyr Tyr Gly Lys Lys Gly Ile Val Ser Leu Leu Arg Thr
                2645                2650                2655    
Ala Phe Leu Leu Leu Leu Leu Ile Ser Ala Thr Trp Leu Leu Gly Leu
            2660                2665                2670        
Leu Ala Val Asn Arg Asp Ala Leu Ser Phe His Tyr Leu Phe Ala Ile
        2675                2680                2685            
Phe Ser Gly Leu Gln Gly Pro Phe Val Leu Leu Phe His Cys Val Leu
    2690                2695                2700                
Asn Gln Glu Val Arg Lys His Leu Lys Gly Val Leu Gly Gly Arg Lys
2705                2710                2715                2720
Leu His Leu Glu Asp Ser Ala Thr Thr Arg Ala Thr Leu Leu Thr Arg
                2725                2730                2735    
Ser Leu Asn Cys Asn Thr Thr Phe Gly Asp Gly Pro Asp Met Leu Arg
            2740                2745                2750        
Thr Asp Leu Gly Glu Ser Thr Ala Ser Leu Asp Ser Ile Val Arg Asp
        2755                2760                2765            
Glu Gly Ile Gln Lys Leu Gly Val Ser Ser Gly Leu Val Arg Gly Ser
    2770                2775                2780                
His Gly Glu Pro Asp Ala Ser Leu Met Pro Arg Ser Cys Lys Asp Pro
2785                2790                2795                2800
Pro Gly His Asp Ser Asp Ser Asp Ser Glu Leu Ser Leu Asp Glu Gln
                2805                2810                2815    
Ser Ser Ser Tyr Ala Ser Ser His Ser Ser Asp Ser Glu Asp Asp Gly
            2820                2825                2830        
Val Gly Ala Glu Glu Lys Trp Asp Pro Ala Arg Gly Ala Val His Ser
        2835                2840                2845            
Thr Pro Lys Gly Asp Ala Val Ala Asn His Val Pro Ala Gly Trp Pro
    2850                2855                2860                
Asp Gln Ser Leu Ala Glu Ser Asp Ser Glu Asp Pro Ser Gly Lys Pro
2865                2870                2875                2880
Arg Leu Lys Val Glu Thr Lys Val Ser Val Glu Leu His Arg Glu Glu
                2885                2890                2895    
Gln Gly Ser His Arg Gly Glu Tyr Pro Pro Asp Gln Glu Ser Gly Gly
            2900                2905                2910        
Ala Ala Arg Leu Ala Ser Ser Gln Pro Pro Glu Gln Arg Lys Gly Ile
        2915                2920                2925            
Leu Lys Asn Lys Val Thr Tyr Pro Pro Pro Leu Thr Leu Thr Glu Gln
    2930                2935                2940                
Thr Leu Lys Gly Arg Leu Arg Glu Lys Leu Ala Asp Cys Glu Gln Ser
2945                2950                2955                2960
Pro Thr Ser Ser Arg Thr Ser Ser Leu Gly Ser Gly Gly Pro Asp Cys
                2965                2970                2975    
Ala Ile Thr Val Lys Ser Pro Gly Arg Glu Pro Gly Arg Asp His Leu
            2980                2985                2990        
Asn Gly Val Ala Met Asn Val Arg Thr Gly Ser Ala Gln Ala Asp Gly
        2995                3000                3005            
Ser Asp Ser Glu Lys Pro
    3010                


<210> 9247
<211> 571
<212> PRT
<213> Homo sapiens

<400> 9247
Met Lys Asp Gly Ser Gly Arg Arg Pro Gln Pro Gly Pro Arg Gly Ala
 1               5                  10                  15      
Gly Gly Arg Arg Leu Ala Ser Arg Ala Cys Ala Arg Cys Arg Gly Pro
            20                  25                  30          
Asp Ala Val Arg Gly Val Gly Ala Arg Val Tyr Ala Asp Ala Pro Ala
        35                  40                  45              
Lys Leu Leu Leu Pro Pro Pro Ala Ala Trp Asp Leu Ala Val Arg Leu
    50                  55                  60                  
Arg Gly Ala Glu Ala Ala Ser Glu Arg Gln Val Tyr Ser Val Thr Met
65                  70                  75                  80  
Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu Thr
                85                  90                  95      
Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser Leu
            100                 105                 110         
Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile His
        115                 120                 125             
Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala Leu
    130                 135                 140                 
Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln His
145                 150                 155                 160 
Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp Leu
                165                 170                 175     
Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser Glu
            180                 185                 190         
Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg Ala
        195                 200                 205             
Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu Glu
    210                 215                 220                 
Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys Val
225                 230                 235                 240 
Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro Phe
                245                 250                 255     
Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala Leu
            260                 265                 270         
Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro Glu
        275                 280                 285             
Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser Ala
    290                 295                 300                 
Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile Leu
305                 310                 315                 320 
Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser His
                325                 330                 335     
Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly Val
            340                 345                 350         
Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln His
        355                 360                 365             
Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys Val
    370                 375                 380                 
Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser Ala
385                 390                 395                 400 
Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu Ala
                405                 410                 415     
Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly Leu
            420                 425                 430         
Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser Thr
        435                 440                 445             
Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp Phe
    450                 455                 460                 
Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe Phe
465                 470                 475                 480 
Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly Ile
                485                 490                 495     
Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala Gly
            500                 505                 510         
Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met Asn
        515                 520                 525             
Glu Val Cys Gln Glu Asp Glu Arg Lys Gly Ser Ile Leu Ile Pro Phe
    530                 535                 540                 
Ile Ile Gln Asn Leu Gly Leu Leu Thr Gly Phe Thr Ile Met Val Val
545                 550                 555                 560 
Leu Thr Met Tyr Ser Gly Gln Ile Gln Ile Gly
                565                 570     


<210> 9248
<211> 481
<212> PRT
<213> Homo sapiens

<400> 9248
Met Lys Leu Leu Leu Leu His Pro Ala Phe Gln Ser Cys Leu Leu Leu
 1               5                  10                  15      
Thr Leu Leu Gly Leu Trp Arg Thr Thr Pro Glu Ala His Ala Ser Ser
            20                  25                  30          
Pro Gly Ala Pro Ala Ile Ser Ala Ala Ser Phe Leu Gln Asp Leu Ile
        35                  40                  45              
His Arg Tyr Gly Glu Gly Asp Ser Leu Thr Leu Gln Gln Leu Lys Ala
    50                  55                  60                  
Leu Leu Asn His Leu Asp Val Gly Val Gly Arg Gly Asn Val Thr Gln
65                  70                  75                  80  
His Val Gln Gly His Arg Asn Leu Ser Thr Cys Phe Ser Ser Gly Asp
                85                  90                  95      
Leu Phe Thr Ala His Asn Phe Ser Glu Gln Ser Arg Ile Gly Ser Ser
            100                 105                 110         
Glu Leu Gln Glu Phe Cys Pro Thr Ile Leu Gln Gln Leu Asp Ser Arg
        115                 120                 125             
Ala Cys Thr Ser Glu Asn Gln Glu Asn Glu Glu Asn Glu Gln Thr Glu
    130                 135                 140                 
Glu Gly Arg Pro Ser Ala Val Glu Val Trp Gly Tyr Gly Leu Leu Cys
145                 150                 155                 160 
Val Thr Val Ile Ser Leu Cys Ser Leu Leu Gly Ala Ser Val Val Pro
                165                 170                 175     
Phe Met Lys Lys Thr Phe Tyr Lys Arg Leu Leu Leu Tyr Phe Ile Ala
            180                 185                 190         
Leu Ala Ile Gly Thr Leu Tyr Ser Asn Ala Leu Phe Gln Leu Ile Pro
        195                 200                 205             
Glu Ala Phe Gly Phe Asn Pro Leu Glu Asp Tyr Tyr Val Ser Lys Ser
    210                 215                 220                 
Ala Val Val Phe Gly Gly Phe Tyr Leu Phe Phe Phe Thr Glu Lys Ile
225                 230                 235                 240 
Leu Lys Ile Leu Leu Lys Gln Lys Asn Glu His His His Gly His Ser
                245                 250                 255     
His Tyr Ala Ser Glu Ser Leu Pro Ser Lys Lys Asp Gln Glu Glu Gly
            260                 265                 270         
Val Met Glu Lys Leu Gln Asn Gly Asp Leu Asp His Met Ile Pro Gln
        275                 280                 285             
His Cys Ser Ser Glu Leu Asp Gly Lys Ala Pro Met Val Asp Glu Lys
    290                 295                 300                 
Val Ile Val Gly Ser Leu Ser Val Gln Asp Leu Gln Ala Ser Gln Ser
305                 310                 315                 320 
Ala Cys Tyr Trp Leu Lys Gly Val Arg Tyr Ser Asp Ile Gly Thr Leu
                325                 330                 335     
Ala Trp Met Ile Thr Leu Ser Asp Gly Leu His Asn Phe Ile Asp Gly
            340                 345                 350         
Leu Ala Ile Gly Ala Ser Phe Thr Val Ser Val Phe Gln Gly Ile Ser
        355                 360                 365             
Thr Ser Val Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp
    370                 375                 380                 
Phe Val Ile Leu Leu Asn Ala Gly Met Ser Ile Gln Gln Ala Leu Phe
385                 390                 395                 400 
Phe Asn Phe Leu Ser Ala Cys Cys Cys Tyr Leu Gly Leu Ala Phe Gly
                405                 410                 415     
Ile Leu Ala Gly Ser His Phe Ser Ala Asn Trp Ile Phe Ala Leu Ala
            420                 425                 430         
Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Met Glu Phe Cys
        435                 440                 445             
Ser Val Ala Gln Ala Gly Val Gln Trp Cys His Leu Ser Ser Leu Gln
    450                 455                 460                 
Pro Leu Pro Leu Gly Leu Lys Arg Leu Ser Cys Leu Ser Leu Pro Ser
465                 470                 475                 480 
Asn
    


<210> 9249
<211> 320
<212> PRT
<213> Homo sapiens

<400> 9249
Met Asp Gln Ser Asn Tyr Ser Ser Leu His Gly Phe Ile Leu Leu Gly
 1               5                  10                  15      
Phe Ser Asn His Pro Lys Met Glu Met Ile Leu Ser Gly Val Val Ala
            20                  25                  30          
Ile Phe Tyr Leu Ile Thr Leu Val Gly Asn Thr Ala Ile Ile Leu Ala
        35                  40                  45              
Ser Leu Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Arg
    50                  55                  60                  
Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ile Pro Gln
65                  70                  75                  80  
Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Val Gly
                85                  90                  95      
Cys Ile Ile Gln Leu Tyr Val Tyr Met Trp Leu Gly Ser Val Glu Cys
            100                 105                 110         
Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Phe Thr Ala Ile Cys Lys
        115                 120                 125             
Pro Leu His Tyr Phe Val Val Met Asn Pro His Leu Cys Leu Lys Met
    130                 135                 140                 
Ile Ile Met Ile Trp Ser Ile Ser Leu Ala Asn Ser Val Val Leu Cys
145                 150                 155                 160 
Thr Leu Thr Leu Asn Leu Pro Thr Cys Gly Asn Asn Ile Leu Asp His
                165                 170                 175     
Phe Leu Cys Glu Leu Pro Ala Leu Val Lys Ile Ala Cys Val Asp Thr
            180                 185                 190         
Thr Thr Val Glu Met Ser Val Phe Ala Leu Gly Ile Ile Ile Val Leu
        195                 200                 205             
Thr Pro Leu Ile Leu Ile Leu Ile Ser Tyr Gly Tyr Ile Ala Lys Ala
    210                 215                 220                 
Val Leu Arg Thr Lys Ser Lys Ala Ser Gln Arg Lys Ala Met Asn Thr
225                 230                 235                 240 
Cys Gly Ser His Leu Thr Val Val Ser Met Phe Tyr Gly Thr Ile Ile
                245                 250                 255     
Tyr Met Tyr Leu Gln Pro Gly Asn Arg Ala Ser Lys Asp Gln Gly Lys
            260                 265                 270         
Phe Leu Thr Leu Phe Tyr Thr Val Ile Thr Pro Ser Leu Asn Pro Leu
        275                 280                 285             
Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys Lys Leu
    290                 295                 300                 
Met Arg Phe His His Lys Ser Thr Lys Ile Lys Arg Asn Cys Lys Ser
305                 310                 315                 320 


<210> 9250
<211> 1543
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 181
<223> Xaa = Any Amino Acid

<400> 9250
Met Asn Lys Met Ala Leu Ala Ser Phe Met Lys Gly Arg Thr Val Ile
 1               5                  10                  15      
Gly Thr Pro Asp Glu Glu Thr Met Asp Ile Glu Leu Pro Lys Lys Tyr
            20                  25                  30          
His Glu Met Val Gly Val Ile Phe Ser Asp Thr Phe Ser Tyr Arg Leu
        35                  40                  45              
Lys Phe Asn Trp Gly Tyr Arg Ile Pro Val Ile Lys Glu His Ser Glu
    50                  55                  60                  
Tyr Thr Glu His Cys Trp Ala Met His Gly Glu Ile Phe Cys Tyr Leu
65                  70                  75                  80  
Ala Lys Tyr Trp Leu Lys Gly Phe Val Ala Phe Gln Ala Ala Ile Asn
                85                  90                  95      
Ala Ala Ile Ile Glu Val Thr Thr Asn His Ser Val Met Glu Glu Leu
            100                 105                 110         
Thr Ser Val Ile Gly Ile Asn Met Lys Ile Pro Pro Phe Ile Ser Lys
        115                 120                 125             
Gly Glu Ile Met Asn Glu Trp Phe His Phe Thr Cys Leu Val Ser Phe
    130                 135                 140                 
Ser Ser Phe Ile Tyr Phe Ala Ser Leu Asn Val Ala Arg Glu Arg Gly
145                 150                 155                 160 
Lys Phe Lys Lys Leu Met Thr Val Met Gly Leu Arg Glu Ser Ala Phe
                165                 170                 175     
Trp Leu Ser Trp Xaa Leu Thr Tyr Ile Cys Phe Ile Phe Ile Met Ser
            180                 185                 190         
Ile Phe Met Ala Leu Val Ile Thr Ser Ile Ser Ile Val Phe His Thr
        195                 200                 205             
Gly Phe Met Val Ile Phe Thr Leu Tyr Ser Leu Tyr Gly Leu Ser Leu
    210                 215                 220                 
Ile Ala Leu Ala Phe Leu Met Ser Val Leu Ile Arg Lys Pro Met Leu
225                 230                 235                 240 
Ala Gly Leu Ala Gly Phe Leu Phe Thr Val Phe Trp Gly Cys Leu Gly
                245                 250                 255     
Phe Thr Val Leu Tyr Arg Gln Leu Pro Leu Ser Leu Gly Trp Val Leu
            260                 265                 270         
Ser Leu Leu Ser Pro Phe Ala Phe Thr Ala Gly Met Ala Gln Val Thr
        275                 280                 285             
His Leu Asp Asn Tyr Leu Ser Gly Val Ile Phe Pro Asp Pro Ser Gly
    290                 295                 300                 
Asp Ser Tyr Lys Met Ile Ala Thr Phe Phe Ile Leu Ala Phe Asp Thr
305                 310                 315                 320 
Leu Phe Tyr Leu Ile Phe Thr Leu Tyr Phe Glu Arg Val Leu Pro Asp
                325                 330                 335     
Lys Asp Gly His Gly Asp Ser Pro Leu Phe Phe Leu Lys Ser Ser Phe
            340                 345                 350         
Trp Ser Lys His Gln Asn Thr His His Glu Ile Phe Glu Asn Glu Ile
        355                 360                 365             
Asn Pro Glu His Ser Ser Asp Asp Ser Phe Glu Pro Val Ser Pro Glu
    370                 375                 380                 
Phe His Gly Lys Glu Ala Ile Arg Ile Arg Asn Val Ile Lys Glu Tyr
385                 390                 395                 400 
Asn Gly Lys Thr Gly Lys Val Glu Ala Leu Gln Gly Ile Phe Phe Asp
                405                 410                 415     
Ile Tyr Glu Gly Gln Ile Thr Ala Ile Leu Gly His Asn Gly Ala Gly
            420                 425                 430         
Lys Ser Thr Leu Leu Asn Ile Leu Ser Gly Leu Ser Val Ser Thr Glu
        435                 440                 445             
Gly Ser Ala Thr Ile Tyr Asn Thr Gln Leu Ser Glu Ile Thr Asp Met
    450                 455                 460                 
Glu Glu Ile Arg Lys Asn Ile Gly Phe Cys Pro Gln Phe Asn Phe Gln
465                 470                 475                 480 
Phe Asp Phe Leu Thr Val Arg Glu Asn Leu Arg Val Phe Ala Lys Ile
                485                 490                 495     
Lys Gly Ile Gln Pro Lys Glu Val Glu Gln Glu Val Lys Arg Ile Ile
            500                 505                 510         
Met Glu Leu Asp Met Gln Ser Ile Gln Asp Ile Ile Ala Lys Lys Leu
        515                 520                 525             
Ser Gly Gly Gln Lys Arg Lys Leu Thr Leu Gly Ile Ala Ile Leu Gly
    530                 535                 540                 
Asp Pro Gln Val Leu Leu Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro
545                 550                 555                 560 
Phe Ser Arg His Arg Val Trp Ser Leu Leu Lys Glu His Lys Val Asp
                565                 570                 575     
Arg Leu Ile Leu Phe Ser Thr Gln Phe Met Asp Glu Ala Asp Ile Leu
            580                 585                 590         
Ala Asp Arg Lys Val Phe Leu Ser Asn Gly Lys Leu Lys Cys Ala Gly
        595                 600                 605             
Ser Ser Leu Phe Leu Lys Arg Lys Trp Gly Ile Gly Tyr His Leu Ser
    610                 615                 620                 
Leu His Arg Asn Glu Met Cys Asp Thr Glu Lys Ile Thr Ser Leu Ile
625                 630                 635                 640 
Lys Gln His Ile Pro Asp Ala Lys Leu Thr Thr Glu Ser Glu Glu Lys
                645                 650                 655     
Leu Val Tyr Ser Leu Pro Leu Glu Lys Thr Asn Lys Phe Pro Asp Leu
            660                 665                 670         
Tyr Ser Asp Leu Asp Lys Cys Ser Asp Gln Gly Ile Arg Asn Tyr Ala
        675                 680                 685             
Val Ser Val Thr Ser Leu Asn Glu Val Phe Leu Asn Leu Glu Gly Lys
    690                 695                 700                 
Ser Ala Ile Asp Glu Pro Asp Phe Asp Ile Gly Lys Gln Glu Lys Ile
705                 710                 715                 720 
His Val Thr Arg Asn Thr Gly Asp Glu Ser Glu Met Glu Gln Val Leu
                725                 730                 735     
Cys Ser Leu Pro Glu Thr Arg Lys Ala Val Ser Ser Ala Ala Leu Trp
            740                 745                 750         
Arg Arg Gln Ile Tyr Ala Val Ala Thr Leu Arg Phe Leu Lys Leu Arg
        755                 760                 765             
Arg Glu Arg Arg Ala Leu Leu Cys Leu Leu Leu Val Leu Gly Ile Ala
    770                 775                 780                 
Phe Ile Pro Ile Ile Leu Glu Lys Ile Met Tyr Lys Val Thr Arg Glu
785                 790                 795                 800 
Thr His Cys Trp Glu Phe Ser Pro Ser Met Tyr Phe Leu Ser Leu Glu
                805                 810                 815     
Gln Ile Pro Lys Thr Pro Leu Thr Ser Leu Leu Ile Val Asn Asn Thr
            820                 825                 830         
Gly Ser Asn Ile Glu Asp Leu Val His Ser Leu Lys Cys Gln Asp Ile
        835                 840                 845             
Val Leu Glu Ile Asp Asp Phe Arg Asn Arg Asn Gly Ser Asp Asp Pro
    850                 855                 860                 
Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Asp Gln Lys Asp Tyr Arg
865                 870                 875                 880 
Phe Ser Val Ala Cys Asn Thr Lys Lys Leu Asn Cys Phe Pro Val Leu
                885                 890                 895     
Met Gly Ile Val Ser Asn Ala Leu Met Gly Ile Phe Asn Phe Thr Glu
            900                 905                 910         
Leu Ile Gln Thr Glu Ser Thr Ser Phe Ser Arg Asp Asp Ile Val Leu
        915                 920                 925             
Asp Leu Gly Phe Ile Asp Gly Ser Ile Phe Leu Leu Leu Ile Thr Asn
    930                 935                 940                 
Cys Val Ser Pro Phe Ile Gly Met Ser Ser Ile Ser Asp Tyr Lys Lys
945                 950                 955                 960 
Asn Val Gln Ser Gln Leu Trp Ile Ser Gly Leu Trp Pro Ser Ala Tyr
                965                 970                 975     
Trp Cys Gly Gln Ala Leu Val Asp Ile Pro Leu Tyr Phe Leu Ile Leu
            980                 985                 990         
Phe Ser Ile His Leu Ile Tyr Tyr Phe Ile Phe Leu Gly Phe Gln Leu
        995                 1000                1005            
Ser Trp Glu Leu Met Phe Val Leu Val Val Cys Ile Ile Gly Cys Ala
    1010                1015                1020                
Val Ser Leu Ile Phe Leu Thr Tyr Val Leu Ser Phe Ile Phe Arg Lys
1025                1030                1035                1040
Trp Arg Lys Asn Asn Gly Phe Trp Ser Phe Gly Phe Phe Ile Ile Leu
                1045                1050                1055    
Ile Cys Val Ser Thr Ile Met Val Ser Thr Gln Tyr Glu Lys Leu Asn
            1060                1065                1070        
Leu Ile Leu Cys Met Ile Phe Ile Pro Ser Phe Thr Leu Leu Gly Tyr
        1075                1080                1085            
Val Met Leu Leu Ile Gln Leu Asp Phe Met Arg Asn Leu Asp Ser Leu
    1090                1095                1100                
Asp Asn Arg Ile Asn Glu Val Asn Lys Thr Ile Leu Leu Thr Thr Leu
1105                1110                1115                1120
Ile Pro Tyr Leu Gln Ser Val Ile Phe Leu Phe Val Ile Arg Cys Leu
                1125                1130                1135    
Glu Met Lys Tyr Gly Asn Glu Ile Met Asn Lys Asp Pro Val Phe Arg
            1140                1145                1150        
Ile Ser Pro Arg Ser Arg Glu Thr His Pro Asn Pro Glu Glu Pro Glu
        1155                1160                1165            
Glu Glu Asp Glu Asp Val Gln Ala Glu Arg Val Gln Ala Ala Asn Ala
    1170                1175                1180                
Leu Thr Ala Pro Asn Leu Glu Glu Glu Pro Val Ile Thr Ala Ser Cys
1185                1190                1195                1200
Leu His Lys Glu Tyr Tyr Glu Thr Lys Lys Ser Cys Phe Ser Thr Arg
                1205                1210                1215    
Lys Lys Lys Ile Ala Ile Arg Asn Val Ser Phe Cys Val Lys Lys Gly
            1220                1225                1230        
Glu Val Leu Gly Leu Leu Gly His Asn Gly Ala Gly Lys Ser Thr Ser
        1235                1240                1245            
Ile Lys Met Ile Thr Gly Cys Thr Lys Pro Thr Ala Gly Val Val Val
    1250                1255                1260                
Leu Gln Gly Ser Arg Ala Ser Val Arg Gln Gln His Asp Asn Ser Leu
1265                1270                1275                1280
Lys Phe Leu Gly Tyr Cys Pro Gln Glu Asn Ser Leu Trp Pro Lys Leu
                1285                1290                1295    
Thr Met Lys Glu His Leu Glu Leu Tyr Ala Ala Val Lys Gly Leu Gly
            1300                1305                1310        
Lys Glu Asp Ala Ala Leu Ser Ile Ser Arg Leu Val Glu Ala Leu Lys
        1315                1320                1325            
Leu Gln Glu Gln Leu Lys Ala Pro Val Lys Thr Leu Ser Glu Gly Ile
    1330                1335                1340                
Lys Arg Lys Leu Cys Phe Val Leu Ser Ile Leu Gly Asn Pro Ser Val
1345                1350                1355                1360
Val Leu Leu Asp Glu Pro Phe Thr Gly Met Asp Pro Glu Gly Gln Gln
                1365                1370                1375    
Gln Met Trp Gln Ile Leu Gln Ala Thr Val Lys Asn Lys Glu Arg Gly
            1380                1385                1390        
Thr Leu Leu Thr Thr His Tyr Met Ser Glu Ala Glu Ala Val Cys Asp
        1395                1400                1405            
Arg Met Ala Met Met Val Ser Gly Thr Leu Arg Cys Ile Gly Ser Ile
    1410                1415                1420                
Gln His Leu Lys Asn Lys Phe Gly Arg Asp Tyr Leu Leu Glu Ile Lys
1425                1430                1435                1440
Met Lys Glu Pro Thr Gln Val Glu Ala Leu His Thr Glu Ile Leu Lys
                1445                1450                1455    
Leu Phe Pro Gln Ala Ala Trp Gln Glu Arg Tyr Ser Ser Leu Met Ala
            1460                1465                1470        
Tyr Lys Leu Pro Val Glu Asp Val His Pro Leu Ser Arg Ala Phe Phe
        1475                1480                1485            
Lys Leu Glu Ala Met Lys Gln Thr Phe Asn Leu Glu Glu Tyr Ser Leu
    1490                1495                1500                
Ser Gln Ala Thr Leu Glu Gln Val Phe Leu Glu Leu Cys Lys Glu Gln
1505                1510                1515                1520
Glu Leu Gly Asn Val Asp Asp Lys Ile Asp Thr Thr Val Glu Trp Lys
                1525                1530                1535    
Leu Leu Pro Gln Glu Asp Pro
            1540            


<210> 9251
<211> 1543
<212> PRT
<213> Homo sapiens

<400> 9251
Met Asn Lys Met Ala Leu Ala Ser Phe Met Lys Gly Arg Thr Val Ile
 1               5                  10                  15      
Gly Thr Pro Asp Glu Glu Thr Met Asp Ile Glu Leu Pro Lys Lys Tyr
            20                  25                  30          
His Glu Met Val Gly Val Ile Phe Ser Asp Thr Phe Ser Tyr Arg Leu
        35                  40                  45              
Lys Phe Asn Trp Gly Tyr Arg Ile Pro Val Ile Lys Glu His Ser Glu
    50                  55                  60                  
Tyr Thr Glu His Cys Trp Ala Met His Gly Glu Ile Phe Cys Tyr Leu
65                  70                  75                  80  
Ala Lys Tyr Trp Leu Lys Gly Phe Val Ala Phe Gln Ala Ala Ile Asn
                85                  90                  95      
Ala Ala Ile Ile Glu Val Thr Thr Asn His Ser Val Met Glu Glu Leu
            100                 105                 110         
Thr Ser Val Ile Gly Ile Asn Met Lys Ile Pro Pro Phe Ile Ser Lys
        115                 120                 125             
Gly Glu Ile Met Asn Glu Trp Phe His Phe Thr Cys Leu Val Ser Phe
    130                 135                 140                 
Ser Ser Phe Ile Tyr Phe Ala Ser Leu Asn Val Ala Arg Glu Arg Gly
145                 150                 155                 160 
Lys Phe Lys Lys Leu Met Thr Val Met Gly Leu Arg Glu Ser Ala Phe
                165                 170                 175     
Trp Leu Ser Trp Gly Leu Thr Tyr Ile Cys Phe Ile Phe Ile Met Ser
            180                 185                 190         
Ile Phe Met Ala Leu Val Ile Thr Ser Ile Pro Ile Val Phe His Thr
        195                 200                 205             
Gly Phe Met Val Ile Phe Thr Leu Tyr Ser Leu Tyr Gly Leu Ser Leu
    210                 215                 220                 
Ile Ala Leu Ala Phe Leu Met Ser Val Leu Ile Arg Lys Pro Met Leu
225                 230                 235                 240 
Ala Gly Leu Ala Gly Phe Leu Phe Thr Val Phe Trp Gly Cys Leu Gly
                245                 250                 255     
Phe Thr Val Leu Tyr Arg Gln Leu Pro Leu Ser Leu Gly Trp Val Leu
            260                 265                 270         
Ser Leu Leu Ser Pro Phe Ala Phe Thr Ala Gly Met Ala Gln Val Thr
        275                 280                 285             
His Leu Asp Asn Tyr Leu Ser Gly Val Ile Phe Pro Asp Pro Ser Gly
    290                 295                 300                 
Asp Ser Tyr Lys Met Ile Ala Thr Phe Phe Ile Leu Ala Phe Asp Thr
305                 310                 315                 320 
Leu Phe Tyr Leu Ile Phe Thr Leu Tyr Phe Glu Arg Val Leu Pro Asp
                325                 330                 335     
Lys Asp Gly His Gly Asp Ser Pro Leu Phe Phe Leu Lys Ser Ser Phe
            340                 345                 350         
Trp Ser Lys His Gln Asn Thr His His Glu Ile Phe Glu Asn Glu Ile
        355                 360                 365             
Asn Pro Glu His Ser Ser Asp Asp Ser Phe Glu Pro Val Ser Pro Glu
    370                 375                 380                 
Phe His Gly Lys Glu Ala Ile Arg Ile Arg Asn Val Ile Lys Glu Tyr
385                 390                 395                 400 
Asn Gly Lys Thr Gly Lys Val Glu Ala Leu Gln Gly Ile Phe Phe Asp
                405                 410                 415     
Ile Tyr Glu Gly Gln Ile Thr Ala Ile Leu Gly His Asn Gly Ala Gly
            420                 425                 430         
Lys Ser Thr Leu Leu Asn Ile Leu Ser Gly Leu Ser Val Ser Thr Glu
        435                 440                 445             
Gly Ser Ala Thr Ile Tyr Asn Thr Gln Leu Ser Glu Ile Thr Asp Met
    450                 455                 460                 
Glu Glu Ile Arg Lys Asn Ile Gly Phe Cys Pro Gln Phe Asn Phe Gln
465                 470                 475                 480 
Phe Asp Phe Leu Thr Val Arg Glu Asn Leu Arg Val Phe Ala Lys Ile
                485                 490                 495     
Lys Gly Ile Gln Pro Lys Glu Val Glu Gln Glu Val Lys Arg Ile Ile
            500                 505                 510         
Met Glu Leu Asp Met Gln Ser Ile Gln Asp Ile Ile Ala Lys Lys Leu
        515                 520                 525             
Ser Gly Gly Gln Lys Arg Lys Leu Thr Leu Gly Ile Ala Ile Leu Gly
    530                 535                 540                 
Asp Pro Gln Val Leu Leu Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro
545                 550                 555                 560 
Phe Ser Arg His Arg Val Trp Ser Leu Leu Lys Glu His Lys Val Asp
                565                 570                 575     
Arg Leu Ile Leu Phe Ser Thr Gln Phe Met Asp Glu Ala Asp Ile Leu
            580                 585                 590         
Ala Asp Arg Lys Val Phe Leu Ser Asn Gly Lys Leu Lys Cys Ala Gly
        595                 600                 605             
Ser Ser Leu Phe Leu Lys Arg Lys Trp Gly Ile Gly Tyr His Leu Ser
    610                 615                 620                 
Leu His Arg Asn Glu Met Cys Asp Thr Glu Lys Ile Thr Ser Leu Ile
625                 630                 635                 640 
Lys Gln His Ile Pro Asp Ala Lys Leu Thr Thr Glu Ser Glu Glu Lys
                645                 650                 655     
Leu Val Tyr Ser Leu Pro Leu Glu Lys Thr Asn Lys Phe Pro Asp Leu
            660                 665                 670         
Tyr Ser Asp Leu Asp Lys Cys Ser Asp Gln Gly Ile Arg Asn Tyr Ala
        675                 680                 685             
Val Ser Val Thr Ser Leu Asn Glu Val Phe Leu Asn Leu Glu Gly Lys
    690                 695                 700                 
Ser Ala Ile Asp Glu Pro Asp Phe Asp Ile Gly Lys Gln Glu Lys Ile
705                 710                 715                 720 
His Val Thr Arg Asn Thr Gly Asp Glu Ser Glu Met Glu Gln Val Leu
                725                 730                 735     
Cys Ser Leu Pro Glu Thr Arg Lys Ala Val Ser Ser Ala Ala Leu Trp
            740                 745                 750         
Arg Arg Gln Ile Tyr Ala Val Ala Thr Leu Arg Phe Leu Lys Leu Arg
        755                 760                 765             
Arg Glu Arg Arg Ala Leu Leu Cys Leu Leu Leu Val Leu Gly Ile Ala
    770                 775                 780                 
Phe Ile Pro Ile Ile Leu Glu Lys Ile Met Tyr Lys Val Thr Arg Glu
785                 790                 795                 800 
Thr His Cys Trp Glu Phe Ser Pro Ser Met Tyr Phe Leu Ser Leu Glu
                805                 810                 815     
Gln Ile Pro Lys Thr Pro Leu Thr Ser Leu Leu Ile Val Asn Asn Thr
            820                 825                 830         
Gly Ser Asn Ile Glu Asp Leu Val His Ser Leu Lys Cys Gln Asp Ile
        835                 840                 845             
Val Leu Glu Ile Asp Asp Phe Arg Asn Arg Asn Gly Ser Asp Asp Pro
    850                 855                 860                 
Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Asp Gln Lys Asp Tyr Arg
865                 870                 875                 880 
Phe Ser Val Ala Cys Asn Thr Lys Lys Leu Asn Cys Phe Pro Val Leu
                885                 890                 895     
Met Gly Ile Val Ser Asn Ala Leu Met Gly Ile Phe Asn Phe Thr Glu
            900                 905                 910         
Leu Ile Gln Met Glu Ser Thr Ser Phe Ser Arg Asp Asp Ile Val Leu
        915                 920                 925             
Asp Leu Gly Phe Ile Asp Gly Ser Ile Phe Leu Leu Leu Ile Thr Asn
    930                 935                 940                 
Cys Val Ser Pro Phe Ile Gly Met Ser Ser Ile Ser Asp Tyr Lys Lys
945                 950                 955                 960 
Asn Val Gln Ser Gln Leu Trp Ile Ser Gly Leu Trp Pro Ser Ala Tyr
                965                 970                 975     
Trp Cys Gly Gln Ala Leu Val Asp Ile Pro Leu Tyr Phe Leu Ile Leu
            980                 985                 990         
Phe Ser Ile His Leu Ile Tyr Tyr Phe Ile Phe Leu Gly Phe Gln Leu
        995                 1000                1005            
Ser Trp Glu Leu Met Phe Val Leu Val Val Cys Ile Ile Gly Cys Ala
    1010                1015                1020                
Val Ser Leu Ile Phe Leu Thr Tyr Val Leu Ser Phe Ile Phe Arg Lys
1025                1030                1035                1040
Trp Arg Lys Asn Asn Gly Phe Trp Ser Phe Gly Phe Phe Ile Ile Leu
                1045                1050                1055    
Ile Cys Val Ser Thr Ile Met Val Ser Thr Gln Tyr Glu Lys Leu Asn
            1060                1065                1070        
Leu Ile Leu Cys Met Ile Phe Ile Pro Ser Phe Thr Leu Leu Gly Tyr
        1075                1080                1085            
Val Met Leu Leu Ile Gln Leu Asp Phe Met Arg Asn Leu Asp Ser Leu
    1090                1095                1100                
Asp Asn Arg Ile Asn Glu Val Asn Lys Thr Ile Leu Leu Thr Thr Leu
1105                1110                1115                1120
Ile Pro Tyr Leu Gln Ser Val Ile Phe Leu Phe Val Ile Arg Cys Leu
                1125                1130                1135    
Glu Met Lys Tyr Gly Asn Glu Ile Met Asn Lys Asp Pro Val Phe Arg
            1140                1145                1150        
Ile Ser Pro Arg Ser Arg Glu Thr His Pro Asn Pro Glu Glu Pro Glu
        1155                1160                1165            
Glu Glu Asp Glu Asp Val Gln Ala Glu Arg Val Gln Ala Ala Asn Ala
    1170                1175                1180                
Leu Thr Ala Pro Asn Leu Glu Glu Glu Pro Val Ile Thr Ala Ser Cys
1185                1190                1195                1200
Leu His Lys Glu Tyr Tyr Glu Thr Lys Lys Ser Cys Phe Ser Thr Ile
                1205                1210                1215    
Lys Lys Lys Ile Ala Ile Arg Asn Val Ser Phe Cys Val Lys Lys Gly
            1220                1225                1230        
Glu Val Leu Gly Leu Leu Gly His Asn Gly Ala Gly Lys Ser Thr Ser
        1235                1240                1245            
Ile Lys Met Ile Thr Gly Cys Thr Lys Pro Thr Ala Gly Val Val Val
    1250                1255                1260                
Leu Gln Gly Ser Arg Ala Ser Val Arg Gln Gln His Asp Asn Ser Leu
1265                1270                1275                1280
Lys Phe Leu Gly Tyr Cys Pro Gln Glu Asn Ser Leu Trp Pro Lys Leu
                1285                1290                1295    
Thr Met Lys Glu His Leu Glu Leu Tyr Ala Ala Val Lys Gly Leu Gly
            1300                1305                1310        
Lys Glu Asp Ala Ala Leu Ser Ile Ser Arg Leu Val Glu Ala Leu Lys
        1315                1320                1325            
Leu Gln Glu Gln Leu Lys Ala Pro Val Lys Thr Leu Ser Glu Gly Ile
    1330                1335                1340                
Lys Arg Lys Leu Cys Phe Val Leu Ser Ile Leu Gly Asn Pro Ser Val
1345                1350                1355                1360
Val Leu Leu Asp Glu Pro Phe Thr Gly Met Asp Pro Glu Gly Gln Gln
                1365                1370                1375    
Gln Met Trp Gln Ile Leu Gln Ala Thr Val Lys Asn Lys Glu Arg Gly
            1380                1385                1390        
Thr Leu Leu Thr Thr His Tyr Met Ser Glu Ala Glu Ala Val Cys Asp
        1395                1400                1405            
Arg Met Ala Met Met Val Ser Gly Thr Leu Arg Cys Ile Gly Ser Ile
    1410                1415                1420                
Gln His Leu Lys Asn Lys Phe Gly Arg Asp Tyr Leu Leu Glu Ile Lys
1425                1430                1435                1440
Met Lys Glu Pro Thr Gln Val Glu Ala Leu His Thr Glu Ile Leu Lys
                1445                1450                1455    
Leu Phe Pro Gln Ala Ala Trp Gln Glu Arg Tyr Ser Ser Leu Met Ala
            1460                1465                1470        
Tyr Lys Leu Pro Val Glu Asp Val His Pro Leu Ser Arg Ala Phe Phe
        1475                1480                1485            
Lys Leu Glu Ala Met Lys Gln Thr Phe Asn Leu Glu Glu Tyr Ser Leu
    1490                1495                1500                
Ser Gln Ala Thr Leu Glu Gln Val Phe Leu Glu Leu Cys Lys Glu Gln
1505                1510                1515                1520
Glu Leu Gly Asn Val Asp Asp Lys Ile Asp Thr Thr Val Glu Trp Lys
                1525                1530                1535    
Leu Leu Pro Gln Glu Asp Pro
            1540            


<210> 9252
<211> 1858
<212> PRT
<213> Homo sapiens

<400> 9252
Met Glu Leu Val Leu Lys Lys Ser Thr Gly His Ser Ala Ala Gln Val
 1               5                  10                  15      
Ala Leu Thr Glu Thr Ala Pro Gly Ser Gln His Ser Ser Pro Leu His
            20                  25                  30          
Val Thr Ala Pro Pro Ser Ala Thr Thr Phe Asp Thr Ala Phe Phe Asn
        35                  40                  45              
Gln Gly Lys Gln Thr Lys Ser Thr Ala Asp Pro Ser Ile Phe Val Ala
    50                  55                  60                  
Thr Tyr Val Ser Val Thr Ser Lys Glu Val Ala Val Asn Asp Asp Glu
65                  70                  75                  80  
Met Asp Asn Phe Leu Pro Asp Thr His Trp Thr Thr Pro Arg Met Val
                85                  90                  95      
Ser Pro Ile Gln Tyr Ile Thr Val Ser Pro Pro Gly Leu Pro Arg Glu
            100                 105                 110         
Ala Leu Glu Pro Met Leu Thr Pro Ser Leu Pro Met Val Ser Leu Gln
        115                 120                 125             
Asp Glu Glu Val Thr Ser Gly Trp Gln Asn Thr Thr Arg Gln Pro Ala
    130                 135                 140                 
Ala Tyr Ala Glu Ser Ala Ser His Phe His Thr Phe Arg Ser Ala Phe
145                 150                 155                 160 
Arg Thr Ser Glu Gly Ile Val Pro Thr Pro Gly Arg Asn Leu Val Leu
                165                 170                 175     
Tyr Pro Thr Asp Ala Tyr Ser His Leu Ser Ser Arg Thr Leu Pro Glu
            180                 185                 190         
Ile Val Ala Ser Leu Thr Glu Gly Val Glu Thr Thr Leu Phe Leu Ser
        195                 200                 205             
Ser Arg Ser Leu Met Pro Gln Pro Leu Gly Asp Gly Ile Thr Ile Pro
    210                 215                 220                 
Leu Pro Ser Leu Gly Glu Val Ser Gln Pro Pro Glu Glu Val Trp Ala
225                 230                 235                 240 
Thr Ser Ala Asp Arg Tyr Thr Asp Val Thr Thr Val Leu Ser Gln Ser
                245                 250                 255     
Leu Glu Glu Thr Ile Ser Pro Arg Thr Tyr Pro Thr Val Thr Ala Ser
            260                 265                 270         
His Ala Ala Leu Ala Phe Ser Arg Thr His Ser Pro Leu Leu Ser Thr
        275                 280                 285             
Pro Leu Ala Phe Ala Ser Ser Ala Ser Pro Thr Asp Val Ser Ser Asn
    290                 295                 300                 
Pro Phe Leu Pro Ser Asp Ser Ser Lys Thr Ser Glu Leu His Ser Asn
305                 310                 315                 320 
Ser Ala Leu Pro Gly Pro Val Asp Asn Thr His Ile Leu Ser Pro Val
                325                 330                 335     
Ser Ser Phe Arg Pro Tyr Thr Trp Cys Ala Ala Cys Thr Val Pro Ser
            340                 345                 350         
Pro Gln Gln Val Leu Ala Thr Ser Leu Met Glu Lys Asp Val Gly Ser
        355                 360                 365             
Gly Asp Gly Ala Glu Thr Leu Cys Met Thr Val Leu Glu Glu Ser Ser
    370                 375                 380                 
Ile Ser Leu Met Ser Ser Val Val Ala Asp Phe Ser Glu Phe Glu Glu
385                 390                 395                 400 
Asp Pro Gln Val Phe Asn Thr Leu Phe Pro Ser Arg Pro Ile Val Pro
                405                 410                 415     
Leu Ser Ser Arg Ser Met Glu Ile Ser Glu Thr Ser Val Gly Ile Ser
            420                 425                 430         
Ala Glu Val Asp Met Ser Ser Val Thr Thr Thr Gln Val Pro Pro Ala
        435                 440                 445             
His Gly Arg Leu Ser Val Pro Ala Ser Leu Asp Pro Thr Ala Gly Ser
    450                 455                 460                 
Leu Ser Val Ala Glu Thr Gln Val Thr Pro Ser Ser Val Thr Thr Ala
465                 470                 475                 480 
Phe Phe Ser Val Ile Thr Ser Ile Leu Leu Asp Ser Ser Phe Ser Val
                485                 490                 495     
Ile Ala Asn Lys Asn Thr Pro Ser Leu Ala Val Arg Asp Pro Ser Val
            500                 505                 510         
Phe Thr Pro Tyr Ser Leu Val Pro Ser Val Glu Ser Ser Leu Phe Ser
        515                 520                 525             
Asp Gln Glu Arg Ser Ser Phe Ser Glu His Lys Pro Arg Gly Ala Leu
    530                 535                 540                 
Asp Phe Ala Ser Ser Phe Phe Ser Thr Pro Pro Leu Glu Leu Ser Gly
545                 550                 555                 560 
Ser Ile Ser Ser Pro Ser Glu Ala Pro Ala Ser Leu Ser Leu Met Pro
                565                 570                 575     
Ser Asp Leu Ser Pro Phe Thr Ser Gln Ser Phe Ser Pro Leu Val Glu
            580                 585                 590         
Thr Phe Thr Leu Phe Asp Ser Ser Asp Leu Gln Ser Ser Gln Leu Ser
        595                 600                 605             
Leu Pro Ser Ser Thr Asn Leu Glu Phe Ser Gln Leu Gln Pro Ser Ser
    610                 615                 620                 
Glu Leu Pro Leu Asn Thr Ile Met Leu Leu Pro Ser Arg Ser Glu Val
625                 630                 635                 640 
Ser Pro Trp Ser Ser Phe Pro Ser Asp Ser Leu Glu Phe Val Glu Ala
                645                 650                 655     
Ser Thr Val Ser Leu Thr Asp Ser Glu Ala His Phe Thr Ser Ala Phe
            660                 665                 670         
Ile Glu Thr Thr Ser Tyr Leu Glu Ser Ser Leu Ile Ser His Glu Ser
        675                 680                 685             
Ala Val Thr Ala Leu Val Pro Pro Gly Ser Glu Ser Phe Asp Ile Leu
    690                 695                 700                 
Thr Ala Gly Ile Gln Ala Thr Ser Pro Leu Thr Thr Val His Thr Thr
705                 710                 715                 720 
Pro Ile Leu Thr Glu Ser Ser Leu Phe Ser Thr Leu Thr Pro Pro Asp
                725                 730                 735     
Asp Gln Ile Ser Ala Leu Asp Gly His Val Ser Val Leu Ala Ser Phe
            740                 745                 750         
Ser Lys Ala Ile Pro Thr Gly Thr Val Leu Ile Thr Asp Ala Tyr Leu
        755                 760                 765             
Pro Ser Gly Ser Ser Phe Val Ser Glu Ala Thr Pro Phe Pro Leu Pro
    770                 775                 780                 
Thr Glu Leu Thr Val Val Gly Pro Ser Leu Thr Pro Thr Glu Val Pro
785                 790                 795                 800 
Leu Asn Thr Ser Thr Glu Val Ser Thr Thr Ser Thr Gly Ala Ala Thr
                805                 810                 815     
Gly Gly Pro Leu Asp Ser Thr Leu Met Gly Asp Ala Ala Ser Gln Ser
            820                 825                 830         
Pro Pro Glu Ser Ser Ala Ala Pro Pro Leu Pro Ser Leu Arg Pro Val
        835                 840                 845             
Thr Ala Phe Thr Leu Glu Ala Thr Val Asp Thr Pro Thr Leu Ala Thr
    850                 855                 860                 
Ala Lys Pro Pro Tyr Val Cys Asp Ile Thr Val Pro Asp Ala Tyr Leu
865                 870                 875                 880 
Ile Thr Thr Val Leu Ala Arg Arg Ala Val Gln Glu Tyr Ile Ile Thr
                885                 890                 895     
Ala Ile Lys Glu Val Leu Arg Ile His Phe Asn Arg Ala Val Glu Leu
            900                 905                 910         
Lys Val Tyr Glu Leu Phe Thr Asp Phe Thr Phe Leu Val Thr Ser Gly
        915                 920                 925             
Pro Phe Val Tyr Thr Ala Ile Ser Val Ile Asn Val Leu Ile Asn Ser
    930                 935                 940                 
Lys Leu Val Arg Asp Gln Thr Pro Leu Ile Leu Ser Val Lys Pro Ser
945                 950                 955                 960 
Phe Leu Val Pro Glu Ser Arg Phe Gln Val Gln Thr Val Leu Gln Phe
                965                 970                 975     
Val Pro Pro Ser Val Asp Thr Gly Phe Cys Asn Phe Thr Gln Arg Ile
            980                 985                 990         
Glu Lys Gly Leu Met Thr Ala Leu Phe Glu Val Arg Lys His His Gln
        995                 1000                1005            
Gly Thr Tyr Asn Leu Thr Val Gln Ile Leu Asn Ile Thr Ile Ser Ser
    1010                1015                1020                
Ser Arg Val Thr Pro Arg Arg Gly Pro Val Asn Ile Ile Phe Ala Val
1025                1030                1035                1040
Lys Ser Thr Gln Gly Phe Leu Asn Gly Ser Glu Val Ser Glu Leu Leu
                1045                1050                1055    
Arg Asn Leu Ser Val Val Glu Phe Ser Phe Tyr Leu Gly Tyr Pro Val
            1060                1065                1070        
Leu Gln Ile Ala Glu Pro Phe Gln Tyr Pro Gln Leu Asn Leu Ser Gln
        1075                1080                1085            
Leu Leu Lys Ser Ser Trp Val Arg Thr Val Leu Leu Gly Val Met Glu
    1090                1095                1100                
Lys Gln Leu Gln Asn Glu Val Phe Gln Ala Glu Met Glu Arg Lys Leu
1105                1110                1115                1120
Ala Gln Leu Leu Ser Glu Val Ser Thr Arg Arg Arg Met Trp Arg Arg
                1125                1130                1135    
Ala Thr Val Ala Ala Gly Asn Ser Val Val Gln Val Val Asn Val Ser
            1140                1145                1150        
Arg Leu Glu Gly Asp Asp Asn Pro Val Gln Leu Ile Tyr Phe Val Glu
        1155                1160                1165            
Asp Gln Asp Gly Glu Arg Leu Ser Ala Val Lys Ser Ser Asp Leu Ile
    1170                1175                1180                
Asn Lys Met Asp Leu Gln Arg Ala Ala Ile Ile Leu Gly Tyr Arg Ile
1185                1190                1195                1200
Gln Gly Val Ile Ala Gln Pro Val Asp Arg Val Lys Arg Pro Ser Pro
                1205                1210                1215    
Glu Ser Gln Ser Asn Asn Leu Trp Val Ile Val Gly Val Val Ile Pro
            1220                1225                1230        
Val Leu Val Val Met Val Ile Val Val Ile Leu Tyr Trp Lys Leu Cys
        1235                1240                1245            
Arg Thr Asp Lys Leu Asp Phe Gln Pro Asp Thr Val Ala Asn Ile Gln
    1250                1255                1260                
Gln Arg Gln Lys Leu Gln Ile Pro Ser Val Lys Gly Phe Asp Phe Ala
1265                1270                1275                1280
Lys Gln His Leu Gly Gln His Asn Lys Asp Asp Ile Leu Ile Ile His
                1285                1290                1295    
Glu Pro Ala Pro Leu Pro Gly Pro Leu Lys Asp His Thr Thr Pro Ser
            1300                1305                1310        
Glu Asn Gly Asp Val Pro Ser Pro Lys Ser Lys Ile Pro Ser Lys Asn
        1315                1320                1325            
Val Arg His Arg Gly Arg Val Ser Pro Ser Asp Ala Asp Ser Thr Val
    1330                1335                1340                
Ser Glu Glu Ser Ser Glu Arg Asp Ala Gly Asp Lys Thr Pro Gly Ala
1345                1350                1355                1360
Val Asn Asp Gly Arg Ser His Arg Ala Pro Gln Ser Gly Pro Pro Leu
                1365                1370                1375    
Pro Ser Ser Gly Asn Glu Gln His Ser Ser Ala Ser Ile Phe Glu His
            1380                1385                1390        
Val Asp Arg Ile Ser Arg Pro Pro Glu Ala Ser Arg Arg Val Pro Ser
        1395                1400                1405            
Lys Ile Gln Leu Ile Ala Met Gln Pro Ile Pro Ala Pro Pro Val Gln
    1410                1415                1420                
Arg Pro Ser Pro Ala Asp Arg Val Ala Glu Ser Asn Lys Ile Asn Lys
1425                1430                1435                1440
Glu Ile Gln Thr Ala Leu Arg His Lys Ser Glu Ile Glu His His Arg
                1445                1450                1455    
Asn Lys Ile Arg Leu Arg Ala Lys Arg Arg Gly His Tyr Glu Phe Pro
            1460                1465                1470        
Val Val Asp Asp Leu Ser Ser Gly Asp Thr Lys Glu Arg His Arg Val
        1475                1480                1485            
Tyr Arg Arg Ala Gln Met Gln Ile Asp Lys Ile Leu Asp Pro Thr Ala
    1490                1495                1500                
Ser Val Pro Ser Val Phe Ile Glu Pro Arg Lys Ser Ser Arg Ile Lys
1505                1510                1515                1520
Arg Ser Pro Lys Pro Arg Arg Lys His Gln Val Asn Gly Cys Pro Ala
                1525                1530                1535    
Asp Ala Glu Lys Asp Arg Leu Ile Thr Thr Asp Ser Asp Gly Thr Tyr
            1540                1545                1550        
Arg Arg Pro Pro Gly Val His Asn Ser Ala Tyr Ile Gly Cys Pro Ser
        1555                1560                1565            
Asp Pro Asp Leu Pro Ala Asp Val Gln Thr Pro Ser Ser Val Glu Leu
    1570                1575                1580                
Gly Arg Tyr Pro Ala Leu Pro Phe Pro Ala Ser Gln Tyr Ile Pro Pro
1585                1590                1595                1600
Gln Pro Ser Ile Glu Glu Ala Arg Gln Thr Met His Ser Leu Leu Asp
                1605                1610                1615    
Asp Ala Phe Ala Leu Val Ala Pro Ser Ser Gln Pro Ala Ser Thr Ala
            1620                1625                1630        
Gly Val Gly Pro Gly Val Pro Pro Gly Leu Pro Ala Asn Ser Thr Pro
        1635                1640                1645            
Ser Gln Glu Glu Arg Arg Ala Thr Gln Trp Gly Ser Phe Tyr Ser Pro
    1650                1655                1660                
Ala Gln Thr Ala Asn Asn Pro Cys Ser Arg Tyr Glu Asp Tyr Gly Met
1665                1670                1675                1680
Thr Pro Pro Thr Gly Pro Leu Pro Arg Pro Gly Phe Gly Pro Gly Leu
                1685                1690                1695    
Leu Gln Ser Thr Glu Leu Val Pro Pro Asp Pro Gln Gln Pro Gln Ala
            1700                1705                1710        
Ser Ala Glu Ala Pro Phe Ala Ala Arg Gly Ile Tyr Ser Glu Glu Met
        1715                1720                1725            
Pro Ser Val Ala Arg Pro Arg Pro Val Gly Gly Thr Thr Gly Ser Gln
    1730                1735                1740                
Ile Gln His Leu Thr Gln Val Gly Ile Ala Ser Arg Ile Gly Ala Gln
1745                1750                1755                1760
Pro Val Glu Ile Pro Pro Ser Arg Gly Ser Gln Tyr Gly Gly Pro Gly
                1765                1770                1775    
Trp Pro Ser Tyr Gly Glu Asp Glu Ala Gly Arg Arg Glu Ala Val Pro
            1780                1785                1790        
Arg Thr Ser Gly Arg Glu Pro Ser Ala Pro Ser Gly Asn Leu Pro His
        1795                1800                1805            
Arg Gly Leu Gln Gly Pro Gly Leu Gly Tyr Pro Thr Ser Ser Thr Glu
    1810                1815                1820                
Asp Leu Gln Pro Gly His Ser Ser Ala Ser Leu Ile Lys Ala Ile Arg
1825                1830                1835                1840
Glu Glu Leu Leu Arg Leu Ser Gln Lys Gln Ser Thr Val Gln Asn Phe
                1845                1850                1855    
His Ser
        


<210> 9253
<211> 391
<212> PRT
<213> Homo sapiens

<400> 9253
Met Asn Ala Ser Ser Arg Asn Val Phe Asp Thr Leu Ile Arg Val Leu
 1               5                  10                  15      
Thr Glu Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe
            20                  25                  30          
Phe Gly His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg
        35                  40                  45              
Cys Asn Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe
    50                  55                  60                  
Phe Val Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys
65                  70                  75                  80  
Met Thr Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly
                85                  90                  95      
Leu Leu Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe
            100                 105                 110         
His Pro Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu
        115                 120                 125             
Thr Ser Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr
    130                 135                 140                 
Gly Phe Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu
145                 150                 155                 160 
Ile Phe Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly
                165                 170                 175     
Ala Ile Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile
            180                 185                 190         
Thr Phe Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys
        195                 200                 205             
Leu Leu Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser
    210                 215                 220                 
His Ile Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu
225                 230                 235                 240 
Thr Ile Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly
                245                 250                 255     
Asn Glu Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile
            260                 265                 270         
Asp His Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln
        275                 280                 285             
Gln Asp Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr
    290                 295                 300                 
Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu
305                 310                 315                 320 
Trp Gly Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys
                325                 330                 335     
Tyr Arg Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr
            340                 345                 350         
Pro His Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg
        355                 360                 365             
Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn
    370                 375                 380                 
Glu Thr Asp Asp Thr Lys Met
385                 390     


<210> 9254
<211> 389
<212> PRT
<213> Homo sapiens

<400> 9254
Met Pro Thr Val Tyr Leu Cys Ser Glu Gln Ile Arg Val Leu Thr Glu
 1               5                  10                  15      
Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly
            20                  25                  30          
His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn
        35                  40                  45              
Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val
    50                  55                  60                  
Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr
65                  70                  75                  80  
Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu
                85                  90                  95      
Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro
            100                 105                 110         
Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser
        115                 120                 125             
Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe
    130                 135                 140                 
Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe
145                 150                 155                 160 
Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile
                165                 170                 175     
Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe
            180                 185                 190         
Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu
        195                 200                 205             
Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile
    210                 215                 220                 
Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile
225                 230                 235                 240 
Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu
                245                 250                 255     
Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His
            260                 265                 270         
Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp
        275                 280                 285             
Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala
    290                 295                 300                 
Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly
305                 310                 315                 320 
Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg
                325                 330                 335     
Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His
            340                 345                 350         
Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys
        355                 360                 365             
Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr
    370                 375                 380                 
Asp Asp Thr Lys Met
385                 


<210> 9255
<211> 372
<212> PRT
<213> Homo sapiens

<400> 9255
Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe Phe Gly His
 1               5                  10                  15      
Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg Cys Asn Ile
            20                  25                  30          
Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe Phe Val Asp
        35                  40                  45              
Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys Met Thr Ile
    50                  55                  60                  
Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly Leu Leu Trp
65                  70                  75                  80  
Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe His Pro Ser
                85                  90                  95      
Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu Thr Ser Ala
            100                 105                 110         
Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr Gly Phe Arg
        115                 120                 125             
Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu Ile Phe Gln
    130                 135                 140                 
Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly Ala Ile Leu
145                 150                 155                 160 
Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile Thr Phe Ser
                165                 170                 175     
Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys Leu Leu Ile
            180                 185                 190         
Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser His Ile Tyr
        195                 200                 205             
Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu Thr Ile Ile
    210                 215                 220                 
Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly Asn Glu Asn
225                 230                 235                 240 
Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile Asp His Asn
                245                 250                 255     
Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln Gln Asp Phe
            260                 265                 270         
Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr Ser Ala Thr
        275                 280                 285             
Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu Trp Gly Tyr
    290                 295                 300                 
Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys Tyr Arg Val
305                 310                 315                 320 
Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr Pro His Cys
                325                 330                 335     
Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg Met Lys Arg
            340                 345                 350         
Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn Glu Thr Asp
        355                 360                 365             
Asp Thr Lys Met
    370         


<210> 9256
<211> 1079
<212> PRT
<213> Homo sapiens

<400> 9256
Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His
 1               5                  10                  15      
Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly
            20                  25                  30          
Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys
        35                  40                  45              
Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr
    50                  55                  60                  
Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile
65                  70                  75                  80  
Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu
                85                  90                  95      
Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu
            100                 105                 110         
Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr
        115                 120                 125             
Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg
    130                 135                 140                 
Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu
145                 150                 155                 160 
Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala
                165                 170                 175     
Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu
            180                 185                 190         
Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu
        195                 200                 205             
Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu
    210                 215                 220                 
Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn
225                 230                 235                 240 
Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser
                245                 250                 255     
Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn
            260                 265                 270         
Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu
        275                 280                 285             
Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg
    290                 295                 300                 
Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro
305                 310                 315                 320 
Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser
                325                 330                 335     
Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val
            340                 345                 350         
Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala
        355                 360                 365             
Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu
    370                 375                 380                 
Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser
385                 390                 395                 400 
Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn
                405                 410                 415     
Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp
            420                 425                 430         
Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys
        435                 440                 445             
Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala
    450                 455                 460                 
Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr
465                 470                 475                 480 
Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp
                485                 490                 495     
Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly
            500                 505                 510         
Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser
        515                 520                 525             
Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys
    530                 535                 540                 
Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp
545                 550                 555                 560 
Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu
                565                 570                 575     
Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile
            580                 585                 590         
Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala
        595                 600                 605             
Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu
    610                 615                 620                 
Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser
625                 630                 635                 640 
Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr
                645                 650                 655     
Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys
            660                 665                 670         
Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe
        675                 680                 685             
Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr
    690                 695                 700                 
Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro
705                 710                 715                 720 
Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile
                725                 730                 735     
Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys
            740                 745                 750         
Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp
        755                 760                 765             
Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala
    770                 775                 780                 
Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln
785                 790                 795                 800 
Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly
                805                 810                 815     
Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile
            820                 825                 830         
Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser
        835                 840                 845             
Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro
    850                 855                 860                 
Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly
865                 870                 875                 880 
Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile
                885                 890                 895     
Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met
            900                 905                 910         
Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu
        915                 920                 925             
Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His
    930                 935                 940                 
Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys
945                 950                 955                 960 
Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe
                965                 970                 975     
Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr
            980                 985                 990         
Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp Val Ile Pro Glu
        995                 1000                1005            
Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys Lys Lys Lys Lys
    1010                1015                1020                
Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys Pro Tyr Ser Glu
1025                1030                1035                1040
Lys Val Pro Ser Ile Lys Ile Pro Met Asp Ile Met Glu Gln Gln Pro
                1045                1050                1055    
Phe Leu Ser Asp Ser Lys Pro Ser Asp Arg Glu Arg Ser Pro Thr Phe
            1060                1065                1070        
Leu Glu Arg His Thr Ser Cys
        1075                


<210> 9257
<211> 995
<212> PRT
<213> Homo sapiens

<400> 9257
Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His
 1               5                  10                  15      
Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly
            20                  25                  30          
Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys
        35                  40                  45              
Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr
    50                  55                  60                  
Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile
65                  70                  75                  80  
Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu
                85                  90                  95      
Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu
            100                 105                 110         
Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr
        115                 120                 125             
Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg
    130                 135                 140                 
Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu
145                 150                 155                 160 
Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala
                165                 170                 175     
Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu
            180                 185                 190         
Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu
        195                 200                 205             
Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu
    210                 215                 220                 
Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn
225                 230                 235                 240 
Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser
                245                 250                 255     
Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn
            260                 265                 270         
Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu
        275                 280                 285             
Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg
    290                 295                 300                 
Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro
305                 310                 315                 320 
Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser
                325                 330                 335     
Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val
            340                 345                 350         
Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala
        355                 360                 365             
Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu
    370                 375                 380                 
Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser
385                 390                 395                 400 
Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn
                405                 410                 415     
Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp
            420                 425                 430         
Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys
        435                 440                 445             
Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala
    450                 455                 460                 
Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr
465                 470                 475                 480 
Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp
                485                 490                 495     
Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly
            500                 505                 510         
Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser
        515                 520                 525             
Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys
    530                 535                 540                 
Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp
545                 550                 555                 560 
Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu
                565                 570                 575     
Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile
            580                 585                 590         
Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala
        595                 600                 605             
Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu
    610                 615                 620                 
Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser
625                 630                 635                 640 
Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr
                645                 650                 655     
Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys
            660                 665                 670         
Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe
        675                 680                 685             
Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr
    690                 695                 700                 
Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro
705                 710                 715                 720 
Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile
                725                 730                 735     
Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys
            740                 745                 750         
Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp
        755                 760                 765             
Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala
    770                 775                 780                 
Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln
785                 790                 795                 800 
Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Phe Ile
                805                 810                 815     
Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met Gly Val Ala Ser
            820                 825                 830         
Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu Leu Leu Met Pro
        835                 840                 845             
Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His Val Pro Leu Arg
    850                 855                 860                 
Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys Leu Ala Leu Leu
865                 870                 875                 880 
Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe Pro Val Met Ile
                885                 890                 895     
Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr Leu Phe Ser Gln
            900                 905                 910         
His Asp Leu Ser Phe Leu Asp Asp Val Ile Pro Glu Lys Asp Lys Lys
        915                 920                 925             
Lys Lys Glu Asp Glu Lys Lys Lys Lys Lys Lys Lys Gly Ser Leu Asp
    930                 935                 940                 
Ser Asp Asn Asp Asp Ser Asp Cys Pro Tyr Ser Glu Lys Val Pro Ser
945                 950                 955                 960 
Ile Lys Ile Pro Met Asp Ile Met Glu Gln Gln Pro Phe Leu Ser Asp
                965                 970                 975     
Ser Lys Pro Ser Asp Arg Glu Arg Ser Pro Thr Phe Leu Glu Arg His
            980                 985                 990         
Thr Ser Cys
        995 


<210> 9258
<211> 1079
<212> PRT
<213> Homo sapiens

<400> 9258
Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His
 1               5                  10                  15      
Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly
            20                  25                  30          
Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys
        35                  40                  45              
Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr
    50                  55                  60                  
Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile
65                  70                  75                  80  
Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu
                85                  90                  95      
Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu
            100                 105                 110         
Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr
        115                 120                 125             
Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg
    130                 135                 140                 
Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu
145                 150                 155                 160 
Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala
                165                 170                 175     
Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu
            180                 185                 190         
Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu
        195                 200                 205             
Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu
    210                 215                 220                 
Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn
225                 230                 235                 240 
Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Phe
                245                 250                 255     
Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn
            260                 265                 270         
Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu
        275                 280                 285             
Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg
    290                 295                 300                 
Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro
305                 310                 315                 320 
Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser
                325                 330                 335     
Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val
            340                 345                 350         
Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala
        355                 360                 365             
Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu
    370                 375                 380                 
Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser
385                 390                 395                 400 
Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn
                405                 410                 415     
Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp
            420                 425                 430         
Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys
        435                 440                 445             
Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala
    450                 455                 460                 
Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr
465                 470                 475                 480 
Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp
                485                 490                 495     
Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly
            500                 505                 510         
Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser
        515                 520                 525             
Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys
    530                 535                 540                 
Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp
545                 550                 555                 560 
Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu
                565                 570                 575     
Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile
            580                 585                 590         
Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala
        595                 600                 605             
Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu
    610                 615                 620                 
Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser
625                 630                 635                 640 
Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr
                645                 650                 655     
Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys
            660                 665                 670         
Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe
        675                 680                 685             
Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr
    690                 695                 700                 
Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro
705                 710                 715                 720 
Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile
                725                 730                 735     
Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys
            740                 745                 750         
Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp
        755                 760                 765             
Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala
    770                 775                 780                 
Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln
785                 790                 795                 800 
Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly
                805                 810                 815     
Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile
            820                 825                 830         
Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser
        835                 840                 845             
Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro
    850                 855                 860                 
Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly
865                 870                 875                 880 
Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile
                885                 890                 895     
Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met
            900                 905                 910         
Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu
        915                 920                 925             
Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His
    930                 935                 940                 
Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys
945                 950                 955                 960 
Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe
                965                 970                 975     
Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr
            980                 985                 990         
Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp Val Ile Pro Glu
        995                 1000                1005            
Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys Lys Lys Lys Lys
    1010                1015                1020                
Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys Pro Tyr Ser Glu
1025                1030                1035                1040
Lys Val Pro Ser Ile Lys Ile Pro Met Asp Ile Met Glu Gln Gln Pro
                1045                1050                1055    
Phe Leu Ser Asp Ser Lys Pro Ser Asp Arg Glu Arg Ser Pro Thr Phe
            1060                1065                1070        
Leu Glu Arg His Thr Ser Cys
        1075                


<210> 9259
<211> 670
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 2, 18
<223> Xaa = Any Amino Acid

<400> 9259
Glu Xaa Val Glu Gly His His Thr Ile Tyr Ile Gly Val His Val Pro
 1               5                  10                  15      
Lys Xaa Tyr Arg Arg Arg Arg Arg His Lys Arg Lys Thr Gly His Lys
            20                  25                  30          
Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr Ser Asp Lys Ser
        35                  40                  45              
Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile Leu Lys Pro Leu
    50                  55                  60                  
Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu Gly Glu Glu Asp
65                  70                  75                  80  
Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu Asp Glu Leu Leu
                85                  90                  95      
Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr Ala Arg Trp Ile
            100                 105                 110         
Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg Trp Ser Lys Pro
        115                 120                 125             
His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu Leu Arg Thr Cys
    130                 135                 140                 
Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala Ser Ser Leu Pro
145                 150                 155                 160 
Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu Thr Gly Leu Leu
                165                 170                 175     
Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu Leu Arg Lys His
            180                 185                 190         
Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu Ala Asp Ile Gly
        195                 200                 205             
Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn Pro Asp Asn Gly
    210                 215                 220                 
Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser Ser Leu Asn Asp
225                 230                 235                 240 
Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn Lys Phe Met Lys
                245                 250                 255     
Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu Val Gly Glu Val
            260                 265                 270         
Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg Leu Gln Gln Ala
        275                 280                 285             
Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro Thr Arg Phe Leu
    290                 295                 300                 
Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser Tyr His Glu Ile
305                 310                 315                 320 
Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val Phe His Asp Ile
                325                 330                 335     
Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala Gly Ile Asp Glu
            340                 345                 350         
Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu Trp Asp Pro Ala
        355                 360                 365             
Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser Asp Lys Arg Lys
    370                 375                 380                 
Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn Gly Asp Thr Pro
385                 390                 395                 400 
His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp Cys Glu Glu Leu
                405                 410                 415     
Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys Asp Ile Lys Arg
            420                 425                 430         
Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala Leu Asn Ile Gln
        435                 440                 445             
Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr Val Thr Asn Ala
    450                 455                 460                 
Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp Asn Met Gln Gly
465                 470                 475                 480 
Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly Ala Ile Phe Cys
                485                 490                 495     
Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser Thr Gly Pro Val
            500                 505                 510         
Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys Asp Asn Asn Phe
        515                 520                 525             
Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp Ser Ala Phe Leu
    530                 535                 540                 
Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu Val Gln Tyr Phe
545                 550                 555                 560 
Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile Ser Phe Ile Phe
                565                 570                 575     
Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala Asp Tyr Tyr Pro
            580                 585                 590         
Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu Phe Ser Cys Thr
        595                 600                 605             
Cys Val Pro Pro Asp Pro Gly Glu Gly Ile Thr Leu Cys Val Tyr Ala
    610                 615                 620                 
Arg Phe Val Phe Gly Gly Arg Cys Arg Leu His Ala Cys Lys Phe Ser
625                 630                 635                 640 
Thr Cys Cys His Gly Pro Gln Glu Leu Val Leu Phe Phe Ser Leu Lys
                645                 650                 655     
Asn Ser Ala Thr Glu Phe Asp Val Ser Leu Pro Glu Val Phe
            660                 665                 670 


<210> 9260
<211> 646
<212> PRT
<213> Homo sapiens

<400> 9260
Met Ser Thr Glu Asn Val Glu Gly Lys Pro Ser Asn Leu Gly Glu Arg
 1               5                  10                  15      
Gly Arg Ala Arg Ser Ser Thr Phe Leu Arg Val Val Gln Pro Met Phe
            20                  25                  30          
Asn His Ser Ile Phe Thr Ser Ala Val Ser Pro Ala Ala Glu Arg Ile
        35                  40                  45              
Arg Phe Ile Leu Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu
    50                  55                  60                  
Phe Thr Glu Leu Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu
65                  70                  75                  80  
Trp Lys Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln
                85                  90                  95      
Gly Gly Glu Arg Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His
            100                 105                 110         
Ser Leu Phe Glu Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu
        115                 120                 125             
Asp Arg Glu Ala Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp
    130                 135                 140                 
His Gln Ile Glu Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val
145                 150                 155                 160 
Thr Tyr Thr Leu Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn
                165                 170                 175     
Leu Arg Ser Leu Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg
            180                 185                 190         
Met Phe Thr Asn Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn
        195                 200                 205             
Leu Thr Ser Ser Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp
    210                 215                 220                 
Gln Leu Lys Asn Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala
225                 230                 235                 240 
Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile
                245                 250                 255     
Ala Phe Val Arg Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu
            260                 265                 270         
Val Pro Val Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly
        275                 280                 285             
Lys Ala Lys Ser Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met
    290                 295                 300                 
Ser Asp Glu Val Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His
305                 310                 315                 320 
Asp Leu Ile Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu
                325                 330                 335     
Pro Pro Gly Glu Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser
            340                 345                 350         
Leu Pro Ser Ser Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn
        355                 360                 365             
Val Gln Met Asn Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly
    370                 375                 380                 
Gly His Gly Asp Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly
385                 390                 395                 400 
Gly Leu Ile Lys Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp
                405                 410                 415     
Phe Tyr Asp Ala Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile
            420                 425                 430         
Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly
        435                 440                 445             
Asp Ala Thr Asp Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr
    450                 455                 460                 
Ala Val Ser Gly Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr
465                 470                 475                 480 
Ile Leu Ser Ser Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe
                485                 490                 495     
Asn Phe Ser Lys Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp
            500                 505                 510         
Ile Gly Leu Trp Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp
        515                 520                 525             
Ala Ser Phe Leu Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe
    530                 535                 540                 
Ser Ser Leu Ile Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met
545                 550                 555                 560 
Ile Lys Leu Ala Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly
                565                 570                 575     
Tyr Asn Thr Leu Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Gly Glu
            580                 585                 590         
Gly Ile Thr Leu Cys Val Tyr Ala Arg Phe Val Phe Gly Gly Arg Cys
        595                 600                 605             
Arg Leu His Ala Cys Lys Phe Ser Thr Cys Cys His Gly Pro Gln Glu
    610                 615                 620                 
Leu Val Leu Phe Phe Ser Leu Lys Asn Ser Ala Thr Glu Phe Asp Val
625                 630                 635                 640 
Ser Leu Pro Glu Val Phe
                645     


<210> 9261
<211> 806
<212> PRT
<213> Homo sapiens

<400> 9261
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala
            340                 345                 350         
Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu
        355                 360                 365             
Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe
    370                 375                 380                 
Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser
385                 390                 395                 400 
Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg
                405                 410                 415     
Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser
            420                 425                 430         
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
        435                 440                 445             
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
    450                 455                 460                 
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
465                 470                 475                 480 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
                485                 490                 495     
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
            500                 505                 510         
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
        515                 520                 525             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
    530                 535                 540                 
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
545                 550                 555                 560 
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
                565                 570                 575     
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
            580                 585                 590         
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
        595                 600                 605             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
    610                 615                 620                 
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
625                 630                 635                 640 
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
                645                 650                 655     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
            660                 665                 670         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
        675                 680                 685             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
    690                 695                 700                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
705                 710                 715                 720 
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
                725                 730                 735     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
            740                 745                 750         
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
        755                 760                 765             
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
    770                 775                 780                 
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
785                 790                 795                 800 
Ser Gly Gly Ser Arg Thr
                805     


<210> 9262
<211> 694
<212> PRT
<213> Homo sapiens

<400> 9262
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser
305                 310                 315                 320 
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
                325                 330                 335     
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
            340                 345                 350         
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
        355                 360                 365             
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
    370                 375                 380                 
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
385                 390                 395                 400 
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
                405                 410                 415     
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
            420                 425                 430         
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
        435                 440                 445             
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
    450                 455                 460                 
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
465                 470                 475                 480 
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
                485                 490                 495     
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
            500                 505                 510         
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
        515                 520                 525             
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
    530                 535                 540                 
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
545                 550                 555                 560 
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
                565                 570                 575     
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
            580                 585                 590         
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
        595                 600                 605             
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
    610                 615                 620                 
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
625                 630                 635                 640 
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
                645                 650                 655     
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
            660                 665                 670         
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
        675                 680                 685             
Ser Gly Gly Ser Arg Thr
    690                 


<210> 9263
<211> 808
<212> PRT
<213> Homo sapiens

<400> 9263
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp
305                 310                 315                 320 
Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr
                325                 330                 335     
Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp
            340                 345                 350         
Leu Ser Val His Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu Ala
        355                 360                 365             
Asp Glu Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly
    370                 375                 380                 
Phe Phe Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu
385                 390                 395                 400 
Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile
                405                 410                 415     
Ser Arg Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser
            420                 425                 430         
Met Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly
        435                 440                 445             
Glu Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp
    450                 455                 460                 
Pro Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu
465                 470                 475                 480 
Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile
                485                 490                 495     
Asp Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu
            500                 505                 510         
Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met
        515                 520                 525             
Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu
    530                 535                 540                 
Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala
545                 550                 555                 560 
Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly
                565                 570                 575     
Leu Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr
            580                 585                 590         
Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu
        595                 600                 605             
Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn
    610                 615                 620                 
Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu
625                 630                 635                 640 
Ala Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly
                645                 650                 655     
Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val
            660                 665                 670         
Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu
        675                 680                 685             
Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu
    690                 695                 700                 
Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn
705                 710                 715                 720 
Cys Thr His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala
                725                 730                 735     
Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg
            740                 745                 750         
Val Leu Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro
        755                 760                 765             
Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser
    770                 775                 780                 
Ser Gly Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro
785                 790                 795                 800 
Pro Ser Ser Gly Gly Ser Arg Thr
                805             


<210> 9264
<211> 1536
<212> PRT
<213> Homo sapiens

<400> 9264
Gly Trp Thr Ser His Leu Ser Asn Cys Gly Glu Ser Asn Arg Pro Pro
 1               5                  10                  15      
Lys Glu Arg Ser Cys Phe Arg Val Cys Asp Trp His Ser Asp Leu Phe
            20                  25                  30          
Gln Trp Glu Val Ser Asp Trp His His Cys Val Leu Val Pro Tyr Ala
        35                  40                  45              
Arg Gly Glu Val Lys Pro Arg Thr Ala Glu Cys Val Thr Ala Gln His
    50                  55                  60                  
Gly Leu Gln His Arg Met Val Arg Cys Ile Gln Lys Leu Asn Arg Thr
65                  70                  75                  80  
Val Val Ala Asn Glu Ile Cys Glu His Phe Ala Leu Gln Pro Pro Thr
                85                  90                  95      
Glu Gln Ala Cys Leu Ile Pro Cys Pro Arg Asp Cys Val Val Ser Glu
            100                 105                 110         
Phe Leu Pro Trp Ser Asn Cys Ser Lys Gly Cys Gly Lys Lys Leu Gln
        115                 120                 125             
His Arg Thr Arg Ala Val Ile Ala Pro Pro Leu Phe Gly Gly Leu Gln
    130                 135                 140                 
Cys Pro Asn Leu Thr Glu Ser Arg Ala Cys Asp Ala Pro Ile Ser Cys
145                 150                 155                 160 
Pro Leu Gly Glu Glu Glu Tyr Thr Phe Ser Leu Lys Val Gly Pro Trp
                165                 170                 175     
Ser Lys Cys Arg Leu Pro His Leu Lys Glu Ile Asn Pro Ser Gly Arg
            180                 185                 190         
Thr Val Leu Asp Phe Asn Ser Asp Ser Asn Glu Arg Val Thr Phe Lys
        195                 200                 205             
His Gln Ser Tyr Lys Ala His His His Ser Lys Ser Trp Ala Ile Glu
    210                 215                 220                 
Ile Gly Tyr Gln Thr Arg Gln Val Ser Cys Thr Arg Ser Asp Gly Gln
225                 230                 235                 240 
Asn Ala Met Leu Ser Leu Cys Leu Gln Asp Ser Phe Pro Leu Thr Val
                245                 250                 255     
Gln Ser Cys Ile Met Pro Lys Asp Cys Glu Thr Ser Gln Trp Ser Ser
            260                 265                 270         
Trp Ser Pro Cys Ser Lys Thr Cys Arg Ser Gly Ser Leu Leu Pro Gly
        275                 280                 285             
Phe Arg Ser Arg Ser Arg Asn Val Lys His Met Ala Ile Gly Gly Gly
    290                 295                 300                 
Lys Glu Cys Pro Glu Leu Leu Glu Lys Glu Ala Cys Ile Val Glu Gly
305                 310                 315                 320 
Glu Leu Leu Gln Gln Cys Pro Arg Tyr Ser Trp Arg Thr Ser Glu Trp
                325                 330                 335     
Lys Glu Cys Gln Val Ser Leu Leu Leu Glu Gln Gln Asp Pro His Trp
            340                 345                 350         
His Val Thr Gly Pro Val Cys Gly Gly Gly Ile Gln Thr Arg Glu Val
        355                 360                 365             
Tyr Cys Ala Gln Ser Val Pro Ala Ala Ala Ala Leu Arg Ala Lys Glu
    370                 375                 380                 
Val Ser Arg Pro Val Glu Lys Ala Leu Cys Val Gly Pro Ala Pro Leu
385                 390                 395                 400 
Pro Ser Gln Leu Cys Asn Ile Pro Cys Ser Thr Asp Cys Ile Val Ser
                405                 410                 415     
Ser Trp Ser Ala Trp Gly Leu Cys Ile His Glu Asn Cys His Glu Pro
            420                 425                 430         
Gln Gly Lys Lys Gly Phe Arg Thr Arg Gln Arg His Val Leu Met Glu
        435                 440                 445             
Ser Thr Gly Pro Ala Gly His Cys Pro His Leu Val Glu Ser Val Pro
    450                 455                 460                 
Cys Glu Asp Pro Met Cys Tyr Arg Trp Leu Ala Ser Glu Gly Ile Cys
465                 470                 475                 480 
Phe Pro Asp His Gly Lys Cys Gly Leu Gly His Arg Ile Leu Lys Ala
                485                 490                 495     
Val Cys Gln Asn Asp Arg Gly Glu Asp Val Ser Gly Ser Leu Cys Pro
            500                 505                 510         
Val Pro Pro Pro Pro Glu Arg Lys Ser Cys Glu Ile Pro Cys Arg Met
        515                 520                 525             
Asp Cys Val Leu Ser Glu Trp Thr Glu Trp Ser Ser Cys Ser Gln Ser
    530                 535                 540                 
Cys Ser Asn Lys Asn Ser Asp Gly Lys Gln Thr Arg Ser Arg Thr Ile
545                 550                 555                 560 
Leu Ala Leu Ala Gly Glu Gly Gly Lys Pro Cys Pro Pro Ser Gln Ala
                565                 570                 575     
Leu Gln Glu His Arg Leu Cys Asn Asp His Ser Cys Met Gln Leu His
            580                 585                 590         
Trp Glu Thr Ser Pro Trp Gly Pro Cys Ser Glu Asp Thr Leu Val Thr
        595                 600                 605             
Ala Leu Asn Ala Thr Ile Gly Trp Asn Gly Glu Ala Thr Cys Gly Val
    610                 615                 620                 
Gly Ile Gln Thr Arg Arg Val Phe Cys Val Lys Ser His Val Gly Gln
625                 630                 635                 640 
Val Met Thr Lys Arg Cys Pro Asp Ser Thr Arg Pro Glu Thr Val Arg
                645                 650                 655     
Pro Cys Phe Leu Pro Cys Lys Lys Asp Cys Ile Val Thr Ala Phe Ser
            660                 665                 670         
Glu Trp Thr Pro Cys Pro Arg Met Cys Gln Ala Gly Asn Ala Thr Val
        675                 680                 685             
Lys Gln Ser Arg Tyr Arg Ile Ile Ile Gln Glu Ala Ala Asn Gly Gly
    690                 695                 700                 
Gln Glu Cys Pro Asp Thr Leu Tyr Glu Glu Arg Glu Cys Glu Asp Val
705                 710                 715                 720 
Ser Leu Cys Pro Val Tyr Arg Trp Lys Pro Gln Lys Trp Ser Pro Cys
                725                 730                 735     
Ile Leu Val Pro Glu Ser Val Trp Gln Gly Ile Thr Gly Ser Ser Glu
            740                 745                 750         
Ala Cys Gly Lys Gly Leu Gln Thr Arg Ala Val Ser Cys Ile Ser Asp
        755                 760                 765             
Asp Asn Arg Ser Ala Glu Met Met Glu Cys Leu Lys Gln Thr Asn Gly
    770                 775                 780                 
Met Pro Leu Leu Val Gln Glu Cys Thr Val Pro Cys Arg Glu Asp Cys
785                 790                 795                 800 
Thr Phe Thr Ala Trp Ser Lys Phe Thr Pro Cys Ser Thr Asn Cys Glu
                805                 810                 815     
Ala Thr Lys Ser Arg Arg Arg Gln Leu Thr Gly Lys Ser Arg Lys Lys
            820                 825                 830         
Glu Lys Cys Gln Asp Ser Asp Leu Tyr Pro Leu Val Glu Thr Glu Leu
        835                 840                 845             
Cys Pro Cys Asp Glu Phe Ile Ser Gln Pro Tyr Gly Asn Trp Ser Asp
    850                 855                 860                 
Cys Ile Leu Pro Glu Gly Arg Arg Glu Pro His Arg Gly Leu Arg Val
865                 870                 875                 880 
Gln Ala Asp Ser Lys Glu Cys Gly Glu Gly Leu Arg Phe Arg Ala Val
                885                 890                 895     
Ala Cys Ser Asp Lys Asn Gly Arg Pro Val Asp Pro Ser Phe Cys Ser
            900                 905                 910         
Ser Ser Gly Tyr Ile Gln Glu Lys Cys Val Ile Pro Cys Pro Phe Asp
        915                 920                 925             
Cys Lys Leu Ser Asp Trp Ser Ser Trp Gly Ser Cys Ser Ser Ser Cys
    930                 935                 940                 
Gly Ile Gly Val Arg Ile Arg Ser Lys Trp Leu Lys Glu Lys Pro Tyr
945                 950                 955                 960 
Asn Gly Gly Arg Pro Cys Pro Lys Leu Asp Leu Lys Asn Gln Ala Gln
                965                 970                 975     
Val His Glu Ala Val Pro Cys Tyr Ser Glu Cys Asn Gln Tyr Ser Trp
            980                 985                 990         
Val Val Glu His Trp Ser Ser Cys Lys Ile Asn Asn Glu Leu Arg Ser
        995                 1000                1005            
Leu Arg Cys Gly Gly Gly Thr Gln Ser Arg Lys Ile Arg Cys Val Asn
    1010                1015                1020                
Thr Ala Asp Gly Glu Gly Gly Ala Val Asp Ser Asn Leu Cys Asn Gln
1025                1030                1035                1040
Asp Glu Ile Pro Pro Glu Thr Gln Ser Cys Ser Leu Met Cys Pro Asn
                1045                1050                1055    
Glu Cys Val Met Ser Glu Trp Gly Leu Trp Ser Lys Cys Pro Gln Ser
            1060                1065                1070        
Cys Asp Pro His Thr Met Gln Arg Arg Thr Arg His Leu Leu Arg Pro
        1075                1080                1085            
Ser Leu Asn Ser Arg Thr Cys Ala Glu Asp Ser Gln Val Gln Pro Cys
    1090                1095                1100                
Leu Leu Asn Glu Asn Cys Phe Gln Phe Gln Tyr Asn Leu Thr Glu Trp
1105                1110                1115                1120
Ser Thr Cys Gln Leu Ser Glu Asn Ala Pro Cys Gly Gln Gly Val Arg
                1125                1130                1135    
Thr Arg Leu Leu Ser Cys Val Cys Ser Asp Gly Lys Pro Val Ser Met
            1140                1145                1150        
Asp Gln Cys Glu Gln His Asn Leu Glu Lys Pro Gln Arg Met Ser Ile
        1155                1160                1165            
Pro Cys Leu Val Glu Cys Val Val Asn Cys Gln Leu Ser Gly Trp Thr
    1170                1175                1180                
Ala Trp Thr Glu Cys Ser Gln Thr Cys Gly His Gly Gly Arg Met Ser
1185                1190                1195                1200
Arg Thr Arg Phe Ile Ile Met Pro Thr Gln Gly Glu Gly Arg Pro Cys
                1205                1210                1215    
Pro Thr Glu Leu Thr Gln Glu Lys Thr Cys Pro Val Thr Pro Cys Tyr
            1220                1225                1230        
Ser Trp Val Leu Gly Asn Trp Ser Ala Cys Lys Leu Glu Gly Gly Asp
        1235                1240                1245            
Cys Gly Glu Gly Val Gln Ile Arg Ser Leu Ser Cys Met Val His Ser
    1250                1255                1260                
Gly Ser Ile Ser His Ala Ala Gly Arg Val Glu Asp Ala Leu Cys Gly
1265                1270                1275                1280
Glu Met Pro Phe Gln Asp Ser Ile Leu Lys Gln Leu Cys Ser Val Pro
                1285                1290                1295    
Cys Pro Gly Asp Cys His Leu Thr Glu Trp Ser Glu Trp Ser Thr Cys
            1300                1305                1310        
Glu Leu Thr Cys Ile Asp Gly Arg Ser Phe Glu Thr Val Gly Arg Gln
        1315                1320                1325            
Ser Arg Ser Arg Thr Phe Ile Ile Gln Ser Phe Glu Asn Gln Asp Ser
    1330                1335                1340                
Cys Pro Gln Gln Val Leu Glu Thr Arg Pro Cys Thr Gly Gly Lys Cys
1345                1350                1355                1360
Tyr His Tyr Thr Trp Lys Ala Ser Leu Trp Asn Asn Asn Glu Arg Thr
                1365                1370                1375    
Val Trp Cys Gln Arg Ser Asp Gly Val Asn Val Thr Gly Gly Cys Ser
            1380                1385                1390        
Pro Gln Ala Arg Pro Ala Ala Ile Arg Gln Cys Ile Pro Ala Cys Arg
        1395                1400                1405            
Lys Pro Phe Ser Tyr Cys Thr Gln Gly Gly Val Cys Gly Cys Glu Lys
    1410                1415                1420                
Gly Tyr Thr Glu Ile Met Arg Ser Asn Gly Phe Leu Asp Tyr Cys Met
1425                1430                1435                1440
Lys Val Pro Gly Ser Glu Asp Lys Lys Ala Asp Val Lys Asn Leu Ser
                1445                1450                1455    
Gly Lys Asn Arg Pro Val Asn Ser Lys Ile His Asp Ile Phe Lys Gly
            1460                1465                1470        
Trp Ser Leu Gln Pro Leu Asp Pro Asp Gly Arg Val Lys Ile Trp Val
        1475                1480                1485            
Tyr Gly Val Ser Gly Gly Ala Phe Leu Ile Met Ile Phe Leu Ile Phe
    1490                1495                1500                
Thr Ser Tyr Leu Val Cys Lys Lys Pro Lys Pro His Gln Ser Thr Pro
1505                1510                1515                1520
Pro Gln Gln Lys Pro Leu Thr Leu Ala Tyr Asp Gly Asp Leu Asp Met
                1525                1530                1535    


<210> 9265
<211> 483
<212> PRT
<213> Homo sapiens

<400> 9265
Met Ser Val Thr Lys Ser Thr Glu Gly Pro Gln Gly Ala Val Ala Ile
 1               5                  10                  15      
Lys Leu Asp Leu Met Ser Pro Pro Glu Ser Ala Lys Lys Leu Glu Asn
            20                  25                  30          
Lys Asp Ser Thr Phe Leu Asp Glu Ser Pro Ser Glu Ser Ala Gly Leu
        35                  40                  45              
Lys Lys Thr Lys Gly Ile Thr Val Phe Gln Ala Leu Ile His Leu Val
    50                  55                  60                  
Lys Gly Asn Met Gly Thr Gly Ile Leu Gly Leu Pro Leu Ala Val Lys
65                  70                  75                  80  
Asn Ala Gly Ile Leu Met Gly Pro Leu Ser Leu Leu Val Met Gly Phe
                85                  90                  95      
Ile Ala Cys His Cys Met His Ile Leu Val Lys Cys Ala Gln Arg Phe
            100                 105                 110         
Cys Lys Arg Leu Asn Lys Pro Phe Met Asp Tyr Gly Asp Thr Val Met
        115                 120                 125             
His Gly Leu Glu Ala Asn Pro Asn Ala Trp Leu Gln Asn His Ala His
    130                 135                 140                 
Trp Gly Arg His Ile Val Ser Phe Phe Leu Ile Asn Thr Gln Leu Gly
145                 150                 155                 160 
Phe Cys Cys Val Tyr Ile Val Phe Leu Ala Asp Asn Leu Lys Gln Val
                165                 170                 175     
Val Glu Ala Val Asn Ser Thr Thr Asn Asn Cys Tyr Ser Asn Glu Thr
            180                 185                 190         
Val Ile Leu Thr Pro Thr Met Asp Ser Arg Leu Tyr Met Leu Ser Phe
        195                 200                 205             
Leu Pro Phe Leu Val Leu Leu Val Leu Ile Arg Asn Leu Arg Ile Leu
    210                 215                 220                 
Thr Ile Phe Ser Met Leu Ala Asn Ile Ser Met Leu Val Ser Leu Val
225                 230                 235                 240 
Ile Ile Ile Gln Tyr Ile Thr Gln Glu Ile Pro Asp Pro Ser Arg Leu
                245                 250                 255     
Pro Leu Val Ala Ser Trp Lys Thr Tyr Pro Leu Phe Phe Gly Thr Ala
            260                 265                 270         
Ile Phe Ser Phe Glu Ser Ile Gly Val Val Leu Pro Leu Glu Asn Lys
        275                 280                 285             
Met Lys Asn Ala Arg His Phe Pro Ala Ile Leu Ser Leu Gly Met Ser
    290                 295                 300                 
Ile Val Thr Ser Leu Tyr Ile Gly Met Ala Ala Leu Gly Tyr Leu Arg
305                 310                 315                 320 
Phe Gly Asp Asp Ile Lys Ala Ser Ile Ser Leu Asn Leu Pro Asn Cys
                325                 330                 335     
Trp Leu Tyr Gln Ser Val Lys Leu Leu Tyr Ile Ala Gly Ile Leu Cys
            340                 345                 350         
Thr Tyr Ala Leu Gln Phe Tyr Val Pro Ala Glu Ile Ile Ile Pro Phe
        355                 360                 365             
Ala Ile Ser Arg Val Ser Thr Arg Trp Ala Leu Pro Leu Asp Leu Ser
    370                 375                 380                 
Ile Arg Leu Val Met Val Cys Leu Thr Cys Leu Leu Ala Ile Leu Ile
385                 390                 395                 400 
Pro Arg Leu Asp Leu Val Ile Pro Leu Val Gly Ser Val Ser Gly Thr
                405                 410                 415     
Ala Leu Ala Leu Ile Ile Pro Pro Leu Leu Glu Val Thr Thr Phe Tyr
            420                 425                 430         
Ser Glu Gly Met Ser Pro Leu Thr Ile Phe Lys Asp Ala Leu Ile Ser
        435                 440                 445             
Ile Leu Gly Phe Val Gly Phe Val Val Gly Thr Tyr Gln Ala Leu Asp
    450                 455                 460                 
Glu Leu Leu Lys Ser Glu Asp Ser His Pro Phe Ser Asn Ser Thr Thr
465                 470                 475                 480 
Phe Val Arg
            


<210> 9266
<211> 866
<212> PRT
<213> Homo sapiens

<400> 9266
Met Gly Ser Gln Thr Leu Gln Ile Leu Arg Gln Gly Val Trp Ala Ala
 1               5                  10                  15      
Leu Ser Gly Gly Trp Tyr Tyr Asp Pro His Gln Ala Thr Phe Val Asn
            20                  25                  30          
Ala Leu His Leu Tyr Leu Trp Leu Phe Leu Leu Gly Leu Pro Phe Thr
        35                  40                  45              
Leu Tyr Met Ala Leu Pro Ser Thr Met Ile Ile Val Ala Val Tyr Cys
    50                  55                  60                  
Pro Val Ile Ala Ala Val Phe Ile Val Leu Lys Met Val Asn Tyr Arg
65                  70                  75                  80  
Leu His Arg Ala Leu Asp Ala Gly Glu Val Val Asp Arg Thr Ala Asn
                85                  90                  95      
Glu Phe Thr Asp Gln Arg Thr Lys Ala Glu Gln Gly Asn Cys Ser Thr
            100                 105                 110         
Arg Arg Lys Asp Ser Asn Gly Pro Ser Asp Pro Gly Gly Gly Ile Glu
        115                 120                 125             
Met Ser Glu Phe Ile Arg Glu Ala Thr Pro Pro Val Gly Cys Ser Ser
    130                 135                 140                 
Arg Asn Ser Tyr Ala Gly Leu Asp Pro Ser Asn Gln Ile Gly Ser Gly
145                 150                 155                 160 
Ser Ser Arg Leu Gly Thr Ala Ala Thr Ile Lys Gly Asp Thr Asp Thr
                165                 170                 175     
Ala Lys Thr Ser Asp Asp Ile Ser Leu Ser Leu Gly Gln Ser Ser Ser
            180                 185                 190         
Leu Cys Lys Glu Gly Ser Glu Glu Gln Asp Leu Ala Ala Asp Arg Lys
        195                 200                 205             
Leu Phe Arg Leu Val Ser Asn Asp Ser Phe Ile Ser Ile Gln Pro Ser
    210                 215                 220                 
Leu Ser Ser Cys Gly Gln Asp Leu Pro Arg Asp Phe Ser Asp Lys Val
225                 230                 235                 240 
Asn Leu Pro Ser His Asn His His His His Val Asp Gln Ser Leu Ser
                245                 250                 255     
Ser Ala Cys Asp Thr Glu Val Ala Ser Leu Val Pro Leu His Ser His
            260                 265                 270         
Ser Tyr Arg Lys Asp His Arg Pro Arg Gly Val Pro Arg Thr Ser Ser
        275                 280                 285             
Ser Ala Val Ala Phe Pro Asp Thr Ser Leu Asn Asp Phe Pro Leu Tyr
    290                 295                 300                 
Gln Gln Arg Arg Gly Leu Asp Pro Val Ser Glu Leu Glu Ser Ser Lys
305                 310                 315                 320 
Pro Leu Ser Gly Ser Lys Glu Ser Leu Val Glu Asn Ser Gly Leu Ser
                325                 330                 335     
Gly Glu Phe Gln Leu Ala Gly Asp Leu Lys Ile Asn Thr Ser Gln Pro
            340                 345                 350         
Pro Thr Lys Ser Gly Lys Ser Lys Pro Leu Lys Ala Glu Lys Ser Met
        355                 360                 365             
Asp Ser Leu Arg Ser Leu Ser Thr Arg Ser Ser Gly Ser Thr Glu Ser
    370                 375                 380                 
Tyr Cys Ser Gly Thr Asp Arg Asp Thr Asn Ser Thr Val Ser Ser Tyr
385                 390                 395                 400 
Lys Ser Glu Gln Thr Ser Ser Thr His Ile Glu Ser Ile Leu Ser Glu
                405                 410                 415     
His Glu Glu Ser Pro Lys Ala Gly Thr Lys Ser Gly Arg Lys Lys Glu
            420                 425                 430         
Cys Cys Ala Gly Pro Glu Glu Lys Asn Ser Cys Ala Ser Asp Lys Arg
        435                 440                 445             
Thr Ser Ser Glu Lys Ile Ala Met Glu Ala Ser Thr Asn Ser Gly Val
    450                 455                 460                 
His Glu Ala Lys Asp Pro Thr Pro Ser Asp Glu Met His Asn Gln Arg
465                 470                 475                 480 
Gly Leu Ser Thr Ser Ala Ser Glu Glu Ala Asn Lys Asn Pro His Ala
                485                 490                 495     
Asn Glu Phe Thr Ser Gln Gly Asp Arg Pro Pro Gly Asn Thr Ala Glu
            500                 505                 510         
Asn Lys Glu Glu Lys Ser Asp Lys Ser Ala Val Ser Val Asp Ser Lys
        515                 520                 525             
Val Arg Lys Asp Val Gly Gly Lys Gln Lys Glu Gly Asp Val Arg Pro
    530                 535                 540                 
Lys Ser Ser Ser Val Ile His Arg Thr Ala Ser Ala His Lys Ser Gly
545                 550                 555                 560 
Arg Arg Arg Thr Gly Lys Lys Arg Ala Ser Ser Phe Asp Ser Ser Arg
                565                 570                 575     
His Arg Asp Tyr Val Cys Phe Arg Gly Val Ser Gly Thr Lys Pro His
            580                 585                 590         
Ser Ala Ile Phe Cys His Asp Glu Asp Ser Ser Asp Gln Ser Asp Leu
        595                 600                 605             
Ser Arg Ala Ser Ser Val Gln Ser Ala His Gln Phe Ser Ser Asp Ser
    610                 615                 620                 
Ser Ser Ser Thr Thr Ser His Ser Cys Gln Ser Pro Glu Gly Arg Tyr
625                 630                 635                 640 
Ser Ala Leu Lys Thr Lys His Thr His Lys Glu Arg Gly Thr Asp Ser
                645                 650                 655     
Glu His Thr His Lys Ala His Leu Val Pro Glu Gly Thr Ser Lys Lys
            660                 665                 670         
Arg Ala Thr Arg Arg Thr Ser Ser Thr Asn Ser Ala Lys Thr Arg Ala
        675                 680                 685             
Arg Val Leu Ser Leu Asp Ser Gly Thr Val Ala Cys Leu Asn Asp Ser
    690                 695                 700                 
Asn Arg Leu Met Ala Pro Glu Ser Ile Lys Pro Leu Thr Thr Ser Lys
705                 710                 715                 720 
Ser Asp Leu Glu Ala Lys Glu Gly Glu Val Leu Asp Glu Leu Ser Leu
                725                 730                 735     
Leu Gly Arg Ala Ser Gln Leu Glu Thr Val Thr Arg Ser Arg Asn Ser
            740                 745                 750         
Leu Pro Asn Gln Val Ala Phe Pro Glu Gly Glu Glu Gln Asp Ala Val
        755                 760                 765             
Ser Gly Ala Ala Gln Ala Ser Glu Glu Ala Val Ser Phe Arg Arg Glu
    770                 775                 780                 
Arg Ser Thr Phe Arg Arg Gln Ala Val Arg Arg Arg His Asn Ala Gly
785                 790                 795                 800 
Ser Asn Pro Thr Pro Pro Thr Leu Leu Ile Gly Ser Pro Leu Ser Leu
                805                 810                 815     
Gln Asp Gly Gln Gln Gly Gln Gln Ser Thr Ala Gln Val Lys Val Gln
            820                 825                 830         
Ser Arg Pro Pro Ser Gln Ala Ala Val Leu Ser Ala Ser Ala Ser Leu
        835                 840                 845             
Leu Val Ser Ser Leu Leu Arg Cys Met Arg Leu Val Ala Val Ile Cys
    850                 855                 860                 
His Leu
865     


<210> 9267
<211> 2269
<212> PRT
<213> Homo sapiens

<400> 9267
Met Gly Ser Gln Thr Leu Gln Ile Leu Arg Gln Gly Val Trp Ala Ala
 1               5                  10                  15      
Leu Ser Gly Gly Trp Tyr Tyr Asp Pro His Gln Ala Thr Phe Val Asn
            20                  25                  30          
Ala Leu His Leu Tyr Leu Trp Leu Phe Leu Leu Gly Leu Pro Phe Thr
        35                  40                  45              
Leu Tyr Met Ala Leu Pro Ser Thr Met Ile Ile Val Ala Val Tyr Cys
    50                  55                  60                  
Pro Val Ile Ala Ala Val Phe Ile Val Leu Lys Met Val Asn Tyr Arg
65                  70                  75                  80  
Leu His Arg Ala Leu Asp Ala Gly Glu Val Val Asp Arg Thr Ala Asn
                85                  90                  95      
Glu Phe Thr Asp Gln Arg Thr Lys Ala Glu Gln Gly Asn Cys Ser Thr
            100                 105                 110         
Arg Arg Lys Asp Ser Asn Gly Pro Ser Asp Pro Gly Gly Gly Ile Glu
        115                 120                 125             
Met Ser Glu Phe Ile Arg Glu Ala Thr Pro Pro Val Gly Cys Ser Ser
    130                 135                 140                 
Arg Asn Ser Tyr Ala Gly Leu Asp Pro Ser Asn Gln Ile Gly Ser Gly
145                 150                 155                 160 
Ser Ser Arg Leu Gly Thr Ala Ala Thr Ile Lys Gly Asp Thr Asp Thr
                165                 170                 175     
Ala Lys Thr Ser Asp Asp Ile Ser Leu Ser Leu Gly Gln Ser Ser Ser
            180                 185                 190         
Leu Cys Lys Glu Gly Ser Glu Glu Gln Asp Leu Ala Ala Asp Arg Lys
        195                 200                 205             
Leu Phe Arg Leu Val Ser Asn Asp Ser Phe Ile Ser Ile Gln Pro Ser
    210                 215                 220                 
Leu Ser Ser Cys Gly Gln Asp Leu Pro Arg Asp Phe Ser Asp Lys Val
225                 230                 235                 240 
Asn Leu Pro Ser His Asn His His His His Val Asp Gln Ser Leu Ser
                245                 250                 255     
Ser Ala Cys Asp Thr Glu Val Ala Ser Leu Val Pro Leu His Ser His
            260                 265                 270         
Ser Tyr Arg Lys Asp His Arg Pro Arg Gly Val Pro Arg Thr Ser Ser
        275                 280                 285             
Ser Ala Val Ala Phe Pro Asp Thr Ser Leu Asn Asp Phe Pro Leu Tyr
    290                 295                 300                 
Gln Gln Arg Arg Gly Leu Asp Pro Val Ser Glu Leu Glu Ser Ser Lys
305                 310                 315                 320 
Pro Leu Ser Gly Ser Lys Glu Ser Leu Val Glu Asn Ser Gly Leu Ser
                325                 330                 335     
Gly Glu Phe Gln Leu Ala Gly Asp Leu Lys Ile Asn Thr Ser Gln Pro
            340                 345                 350         
Pro Thr Lys Ser Gly Lys Ser Lys Pro Leu Lys Ala Glu Lys Ser Met
        355                 360                 365             
Asp Ser Leu Arg Ser Leu Ser Thr Arg Ser Ser Gly Ser Thr Glu Ser
    370                 375                 380                 
Tyr Cys Ser Gly Thr Asp Arg Asp Thr Asn Ser Thr Val Ser Ser Tyr
385                 390                 395                 400 
Lys Ser Glu Gln Thr Ser Ser Thr His Ile Glu Ser Ile Leu Ser Glu
                405                 410                 415     
His Glu Glu Ser Pro Lys Ala Gly Thr Lys Ser Gly Arg Lys Lys Glu
            420                 425                 430         
Cys Cys Ala Gly Pro Glu Glu Lys Asn Ser Cys Ala Ser Asp Lys Arg
        435                 440                 445             
Thr Ser Ser Glu Lys Ile Ala Met Glu Ala Ser Thr Asn Ser Gly Val
    450                 455                 460                 
His Glu Ala Lys Asp Pro Thr Pro Ser Asp Glu Met His Asn Gln Arg
465                 470                 475                 480 
Gly Leu Ser Thr Ser Ala Ser Glu Glu Ala Asn Lys Asn Pro His Ala
                485                 490                 495     
Asn Glu Phe Thr Ser Gln Gly Asp Arg Pro Pro Gly Asn Thr Ala Glu
            500                 505                 510         
Asn Lys Glu Glu Lys Ser Asp Lys Ser Ala Val Ser Val Asp Ser Lys
        515                 520                 525             
Val Arg Lys Asp Val Gly Gly Lys Gln Lys Glu Gly Asp Val Arg Pro
    530                 535                 540                 
Lys Ser Ser Ser Val Ile His Arg Thr Ala Ser Ala His Lys Ser Gly
545                 550                 555                 560 
Arg Arg Arg Thr Gly Lys Lys Arg Ala Ser Ser Phe Asp Ser Ser Arg
                565                 570                 575     
His Arg Asp Tyr Val Cys Phe Arg Gly Val Ser Gly Thr Lys Pro His
            580                 585                 590         
Ser Ala Ile Phe Cys His Asp Glu Asp Ser Ser Asp Gln Ser Asp Leu
        595                 600                 605             
Ser Arg Ala Ser Ser Val Gln Ser Ala His Gln Phe Ser Ser Asp Ser
    610                 615                 620                 
Ser Ser Ser Thr Thr Ser His Ser Cys Gln Ser Pro Glu Gly Arg Tyr
625                 630                 635                 640 
Ser Ala Leu Lys Thr Lys His Thr His Lys Glu Arg Gly Thr Asp Ser
                645                 650                 655     
Glu His Thr His Lys Ala His Leu Val Pro Glu Gly Thr Ser Lys Lys
            660                 665                 670         
Arg Ala Thr Arg Arg Thr Ser Ser Thr Asn Ser Ala Lys Thr Arg Ala
        675                 680                 685             
Arg Val Leu Ser Leu Asp Ser Gly Thr Val Ala Cys Leu Asn Asp Ser
    690                 695                 700                 
Asn Arg Leu Met Ala Pro Glu Ser Ile Lys Pro Leu Thr Thr Ser Lys
705                 710                 715                 720 
Ser Asp Leu Glu Ala Lys Glu Gly Glu Val Leu Asp Glu Leu Ser Leu
                725                 730                 735     
Leu Gly Arg Ala Ser Gln Leu Glu Thr Val Thr Arg Ser Arg Asn Ser
            740                 745                 750         
Leu Pro Asn Gln Val Ala Phe Pro Glu Gly Glu Glu Gln Asp Ala Val
        755                 760                 765             
Ser Gly Ala Ala Gln Ala Ser Glu Glu Ala Val Ser Phe Arg Arg Glu
    770                 775                 780                 
Arg Ser Thr Phe Arg Arg Gln Ala Val Arg Arg Arg His Asn Ala Gly
785                 790                 795                 800 
Ser Asn Pro Thr Pro Pro Thr Leu Leu Ile Gly Ser Pro Leu Ser Leu
                805                 810                 815     
Gln Asp Gly Gln Gln Gly Gln Gln Ser Thr Ala Gln Val Lys Val Gln
            820                 825                 830         
Ser Arg Pro Pro Ser Gln Ala Ala Val Leu Ser Ala Ser Ala Ser Leu
        835                 840                 845             
Leu Val Arg Asn Gly Ser Val His Leu Glu Ala Ser His Asp Asn Ala
    850                 855                 860                 
Ser Ala Val Gly Gly Ser Ser Leu His Asp Glu Leu Gly Lys Phe Ser
865                 870                 875                 880 
Ser Thr Leu Tyr Glu Thr Gly Gly Cys Asp Met Ser Leu Val Asn Phe
                885                 890                 895     
Glu Pro Ala Ala Arg Arg Ala Ser Asn Ile Cys Asp Thr Asp Ser His
            900                 905                 910         
Val Ser Ser Ser Thr Ser Val Arg Phe Tyr Pro His Asp Val Leu Ser
        915                 920                 925             
Leu Pro Gln Ile Arg Leu Asn Arg Leu Leu Thr Ile Asp Thr Asp Leu
    930                 935                 940                 
Leu Glu Gln Gln Asp Ile Asp Leu Ser Pro Asp Leu Ala Ala Thr Tyr
945                 950                 955                 960 
Gly Pro Thr Glu Glu Ala Ala Gln Lys Val Lys His Tyr Tyr Arg Phe
                965                 970                 975     
Trp Ile Leu Pro Gln Leu Trp Ile Gly Ile Asn Phe Asp Arg Leu Thr
            980                 985                 990         
Leu Leu Ala Leu Phe Asp Arg Asn Arg Glu Ile Leu Glu Asn Val Leu
        995                 1000                1005            
Ala Val Ile Leu Ala Ile Leu Val Ala Phe Leu Gly Ser Ile Leu Leu
    1010                1015                1020                
Ile Gln Gly Phe Phe Arg Asp Ile Trp Val Phe Gln Phe Cys Leu Val
1025                1030                1035                1040
Ile Ala Ser Cys Gln Tyr Ser Leu Leu Lys Ser Val Gln Pro Asp Ser
                1045                1050                1055    
Ser Ser Pro Arg His Gly His Asn Arg Ile Ile Ala Tyr Ser Arg Pro
            1060                1065                1070        
Val Tyr Phe Cys Ile Cys Cys Gly Leu Ile Trp Leu Leu Asp Tyr Gly
        1075                1080                1085            
Ser Arg Asn Leu Thr Ala Thr Lys Phe Lys Leu Tyr Gly Ile Thr Phe
    1090                1095                1100                
Thr Asn Pro Leu Val Phe Ile Ser Ala Arg Asp Leu Val Ile Val Phe
1105                1110                1115                1120
Thr Leu Cys Phe Pro Ile Val Phe Phe Ile Gly Leu Leu Pro Gln Val
                1125                1130                1135    
Asn Thr Phe Val Met Tyr Leu Cys Glu Gln Leu Asp Ile His Ile Phe
            1140                1145                1150        
Gly Gly Asn Ala Thr Thr Ser Leu Leu Ala Ala Leu Tyr Ser Phe Ile
        1155                1160                1165            
Cys Ser Ile Val Ala Val Ala Leu Leu Tyr Gly Leu Cys Tyr Gly Ala
    1170                1175                1180                
Leu Lys Asp Ser Trp Asp Gly Gln His Ile Pro Val Leu Phe Ser Ile
1185                1190                1195                1200
Phe Cys Gly Leu Leu Val Ala Val Ser Tyr His Leu Ser Arg Gln Ser
                1205                1210                1215    
Ser Asp Pro Ser Val Leu Phe Ser Leu Val Gln Ser Lys Ile Phe Pro
            1220                1225                1230        
Lys Thr Glu Glu Lys Asn Pro Glu Asp Pro Leu Ser Glu Val Lys Asp
        1235                1240                1245            
Pro Leu Pro Glu Lys Leu Arg Asn Ser Val Ser Glu Arg Leu Gln Ser
    1250                1255                1260                
Asp Leu Val Val Cys Ile Val Ile Gly Val Leu Tyr Phe Ala Ile His
1265                1270                1275                1280
Val Ser Thr Val Phe Thr Val Leu Gln Pro Ala Leu Lys Tyr Val Leu
                1285                1290                1295    
Tyr Thr Leu Val Gly Phe Val Gly Phe Val Thr His Tyr Val Leu Pro
            1300                1305                1310        
Gln Val Arg Lys Gln Leu Pro Trp His Cys Phe Ser His Pro Leu Leu
        1315                1320                1325            
Lys Thr Leu Glu Tyr Asn Gln Tyr Glu Val Arg Asn Ala Ala Thr Met
    1330                1335                1340                
Met Trp Phe Glu Lys Leu His Val Trp Leu Leu Phe Val Glu Lys Asn
1345                1350                1355                1360
Ile Ile Tyr Pro Leu Ile Val Leu Asn Glu Leu Ser Ser Ser Ala Glu
                1365                1370                1375    
Thr Ile Ala Ser Pro Lys Lys Leu Asn Thr Glu Leu Gly Ala Leu Met
            1380                1385                1390        
Ile Thr Val Ala Gly Leu Lys Leu Leu Arg Ser Ser Phe Ser Ser Pro
        1395                1400                1405            
Thr Tyr Gln Tyr Val Thr Val Ile Phe Thr Val Leu Phe Phe Lys Phe
    1410                1415                1420                
Asp Tyr Glu Ala Phe Ser Glu Thr Met Leu Leu Asp Leu Phe Phe Met
1425                1430                1435                1440
Ser Ile Leu Phe Asn Lys Leu Trp Glu Leu Leu Tyr Lys Leu Gln Phe
                1445                1450                1455    
Val Tyr Thr Tyr Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe
            1460                1465                1470        
His Ala Phe Ala Gln Pro Phe Ala Val Pro His Ser Ala Met Leu Phe
        1475                1480                1485            
Ile Gln Ala Ala Val Ser Ala Phe Phe Ser Thr Pro Leu Asn Pro Phe
    1490                1495                1500                
Leu Gly Ser Ala Ile Phe Ile Thr Ser Tyr Val Arg Pro Val Lys Phe
1505                1510                1515                1520
Trp Glu Arg Asp Tyr Asn Thr Lys Arg Val Asp His Ser Asn Thr Arg
                1525                1530                1535    
Leu Ala Ser Gln Leu Asp Arg Asn Pro Gly Thr Tyr Cys Gln Gln Arg
            1540                1545                1550        
Glu Val Glu Ala Ile Thr Glu Gly Val Glu Glu Asp Glu Gly Phe Cys
        1555                1560                1565            
Cys Cys Glu Pro Gly His Ile Pro His Met Leu Ser Phe Asn Ala Ala
    1570                1575                1580                
Phe Ser Gln Arg Trp Leu Ala Trp Glu Val Ile Val Thr Lys Tyr Ile
1585                1590                1595                1600
Leu Glu Gly Tyr Ser Ile Thr Asp Asn Ser Ala Ala Ser Met Leu Gln
                1605                1610                1615    
Val Phe Asp Leu Arg Lys Val Leu Thr Thr Tyr Tyr Val Lys Gly Ile
            1620                1625                1630        
Ile Tyr Tyr Val Thr Thr Ser Ser Lys Leu Glu Glu Trp Leu Ala Asn
        1635                1640                1645            
Glu Thr Met Gln Glu Gly Leu Arg Leu Cys Ala Asp Arg Asn Tyr Val
    1650                1655                1660                
Asp Val Asp Pro Thr Phe Asn Pro Asn Ile Asp Glu Asp Tyr Asp His
1665                1670                1675                1680
Arg Leu Ala Gly Ile Ser Arg Glu Ser Phe Cys Val Ile Tyr Leu Asn
                1685                1690                1695    
Trp Ile Glu Tyr Cys Ser Ser Arg Arg Ala Lys Pro Val Asp Val Asp
            1700                1705                1710        
Lys Asp Ser Ser Leu Val Thr Leu Cys Tyr Gly Leu Cys Val Leu Gly
        1715                1720                1725            
Arg Arg Ala Leu Gly Thr Ala Ser His His Met Ser Ser Asn Leu Glu
    1730                1735                1740                
Ser Phe Leu Tyr Gly Leu His Ala Leu Phe Lys Gly Asp Phe Arg Ile
1745                1750                1755                1760
Ser Ser Ile Arg Asp Glu Trp Ile Phe Ala Asp Met Glu Leu Leu Arg
                1765                1770                1775    
Lys Val Val Val Pro Gly Ile Arg Met Ser Ile Lys Leu His Gln Asp
            1780                1785                1790        
His Phe Thr Ser Pro Asp Glu Tyr Asp Asp Pro Thr Val Leu Tyr Glu
        1795                1800                1805            
Ala Ile Val Ser His Glu Lys Asn Leu Val Ile Ala His Glu Gly Asp
    1810                1815                1820                
Pro Ala Trp Arg Ser Ala Val Leu Ala Asn Ser Pro Ser Leu Leu Ala
1825                1830                1835                1840
Leu Arg His Val Met Asp Asp Gly Thr Asn Glu Tyr Lys Ile Ile Met
                1845                1850                1855    
Leu Asn Arg Arg Tyr Leu Ser Phe Arg Val Ile Lys Val Asn Lys Glu
            1860                1865                1870        
Cys Val Arg Gly Leu Trp Ala Gly Gln Gln Gln Glu Leu Val Phe Leu
        1875                1880                1885            
Arg Asn Arg Asn Pro Glu Arg Gly Ser Ile Gln Asn Ala Lys Gln Ala
    1890                1895                1900                
Leu Arg Asn Met Ile Asn Ser Ser Cys Asp Gln Pro Ile Gly Tyr Pro
1905                1910                1915                1920
Ile Phe Val Ser Pro Leu Thr Thr Ser Tyr Ser Asp Ser His Glu Gln
                1925                1930                1935    
Leu Lys Asp Ile Leu Gly Gly Pro Ile Ser Leu Gly Asn Ile Arg Asn
            1940                1945                1950        
Phe Ile Val Ser Thr Trp His Arg Leu Arg Lys Gly Cys Gly Ala Gly
        1955                1960                1965            
Cys Asn Ser Gly Gly Asn Ile Glu Asp Ser Asp Thr Gly Gly Gly Thr
    1970                1975                1980                
Ser Cys Thr Gly Asn Asn Ala Thr Thr Ala Asn Asn Pro His Ser Asn
1985                1990                1995                2000
Val Thr Gln Gly Ser Ile Gly Asn Pro Gly Gln Gly Ser Gly Thr Gly
                2005                2010                2015    
Leu His Pro Pro Val Thr Ser Tyr Pro Pro Thr Leu Gly Thr Ser His
            2020                2025                2030        
Ser Ser His Ser Val Gln Ser Gly Leu Val Arg Gln Ser Pro Ala Arg
        2035                2040                2045            
Ala Ser Val Ala Ser Gln Ser Ser Tyr Cys Tyr Ser Ser Arg His Ser
    2050                2055                2060                
Ser Leu Arg Met Ser Thr Thr Gly Phe Val Pro Cys Arg Arg Ser Ser
2065                2070                2075                2080
Thr Ser Gln Ile Ser Leu Arg Asn Leu Pro Ser Ser Ile Gln Ser Arg
                2085                2090                2095    
Leu Ser Met Val Asn Gln Met Glu Pro Ser Gly Gln Ser Gly Leu Ala
            2100                2105                2110        
Cys Val Gln His Gly Leu Pro Ser Ser Ser Ser Ser Ser Gln Ser Ile
        2115                2120                2125            
Pro Ala Cys Lys His His Thr Leu Val Gly Phe Leu Ala Thr Glu Gly
    2130                2135                2140                
Gly Gln Ser Ser Ala Thr Asp Ala Gln Pro Gly Asn Thr Leu Ser Pro
2145                2150                2155                2160
Ala Asn Asn Ser His Ser Lys Lys Ala Glu Val Ile Tyr Arg Val Gln
                2165                2170                2175    
Ile Val Asp Pro Ser Gln Ile Leu Glu Gly Ile Asn Leu Ser Lys Arg
            2180                2185                2190        
Lys Glu Leu Gln Trp Pro Asp Glu Gly Ile Arg Leu Lys Ala Gly Arg
        2195                2200                2205            
Asn Ser Trp Lys Asp Trp Ser Pro Gln Glu Gly Met Glu Gly His Val
    2210                2215                2220                
Ile His Arg Trp Val Pro Cys Ser Arg Asp Pro Gly Thr Arg Ser His
2225                2230                2235                2240
Ile Asp Lys Ala Val Leu Leu Val Gln Ile Asp Asp Lys Tyr Val Thr
                2245                2250                2255    
Val Ile Glu Thr Gly Val Leu Glu Leu Gly Ala Glu Val
            2260                2265                


<210> 9268
<211> 2341
<212> PRT
<213> Homo sapiens

<400> 9268
Met Gly Ser Gln Thr Leu Gln Ile Leu Arg Gln Gly Val Trp Ala Ala
 1               5                  10                  15      
Leu Ser Gly Gly Trp Tyr Tyr Asp Pro His Gln Ala Thr Phe Val Asn
            20                  25                  30          
Ala Leu His Leu Tyr Leu Trp Leu Phe Leu Leu Gly Leu Pro Phe Thr
        35                  40                  45              
Leu Tyr Met Ala Leu Pro Ser Thr Met Ile Ile Val Ala Val Tyr Cys
    50                  55                  60                  
Pro Val Ile Ala Ala Val Phe Ile Val Leu Lys Met Val Asn Tyr Arg
65                  70                  75                  80  
Leu His Arg Ala Leu Asp Ala Gly Glu Val Val Asp Arg Thr Ala Asn
                85                  90                  95      
Glu Phe Thr Asp Gln Arg Thr Lys Ala Glu Gln Gly Asn Cys Ser Thr
            100                 105                 110         
Arg Arg Lys Asp Ser Asn Gly Pro Ser Asp Pro Gly Gly Gly Ile Glu
        115                 120                 125             
Met Ser Glu Phe Ile Arg Glu Ala Thr Pro Pro Val Gly Cys Ser Ser
    130                 135                 140                 
Arg Asn Ser Tyr Ala Gly Leu Asp Pro Ser Asn Gln Ile Gly Ser Gly
145                 150                 155                 160 
Ser Ser Arg Leu Gly Thr Ala Ala Thr Ile Lys Gly Asp Thr Asp Thr
                165                 170                 175     
Ala Lys Thr Ser Asp Asp Ile Ser Leu Ser Leu Gly Gln Ser Ser Ser
            180                 185                 190         
Leu Cys Lys Glu Gly Ser Glu Glu Gln Asp Leu Ala Ala Asp Arg Lys
        195                 200                 205             
Leu Phe Arg Leu Val Ser Asn Asp Ser Phe Ile Ser Ile Gln Pro Ser
    210                 215                 220                 
Leu Ser Ser Cys Gly Gln Asp Leu Pro Arg Asp Phe Ser Asp Lys Val
225                 230                 235                 240 
Asn Leu Pro Ser His Asn His His His His Val Asp Gln Ser Leu Ser
                245                 250                 255     
Ser Ala Cys Asp Thr Glu Val Ala Ser Leu Val Pro Leu His Ser His
            260                 265                 270         
Ser Tyr Arg Lys Asp His Arg Pro Arg Gly Val Pro Arg Thr Ser Ser
        275                 280                 285             
Ser Ala Val Ala Phe Pro Asp Thr Ser Leu Asn Asp Phe Pro Leu Tyr
    290                 295                 300                 
Gln Gln Arg Arg Gly Leu Asp Pro Val Ser Glu Leu Glu Ser Ser Lys
305                 310                 315                 320 
Pro Leu Ser Gly Ser Lys Glu Ser Leu Val Glu Asn Ser Gly Leu Ser
                325                 330                 335     
Gly Glu Phe Gln Leu Ala Gly Asp Leu Lys Ile Asn Thr Ser Gln Pro
            340                 345                 350         
Pro Thr Lys Ser Gly Lys Ser Lys Pro Leu Lys Ala Glu Lys Ser Met
        355                 360                 365             
Asp Ser Leu Arg Ser Leu Ser Thr Arg Ser Ser Gly Ser Thr Glu Ser
    370                 375                 380                 
Tyr Cys Ser Gly Thr Asp Arg Asp Thr Asn Ser Thr Val Ser Ser Tyr
385                 390                 395                 400 
Lys Ser Glu Gln Thr Ser Ser Thr His Ile Glu Ser Ile Leu Ser Glu
                405                 410                 415     
His Glu Glu Ser Pro Lys Ala Gly Thr Lys Ser Gly Arg Lys Lys Glu
            420                 425                 430         
Cys Cys Ala Gly Pro Glu Glu Lys Asn Ser Cys Ala Ser Asp Lys Arg
        435                 440                 445             
Thr Ser Ser Glu Lys Ile Ala Met Glu Ala Ser Thr Asn Ser Gly Val
    450                 455                 460                 
His Glu Ala Lys Asp Pro Thr Pro Ser Asp Glu Met His Asn Gln Arg
465                 470                 475                 480 
Gly Leu Ser Thr Ser Ala Ser Glu Glu Ala Asn Lys Asn Pro His Ala
                485                 490                 495     
Asn Glu Phe Thr Ser Gln Gly Asp Arg Pro Pro Gly Asn Thr Ala Glu
            500                 505                 510         
Asn Lys Glu Glu Lys Ser Asp Lys Ser Ala Val Ser Val Asp Ser Lys
        515                 520                 525             
Val Arg Lys Asp Val Gly Gly Lys Gln Lys Glu Gly Asp Val Arg Pro
    530                 535                 540                 
Lys Ser Ser Ser Val Ile His Arg Thr Ala Ser Ala His Lys Ser Gly
545                 550                 555                 560 
Arg Arg Arg Thr Gly Lys Lys Arg Ala Ser Ser Phe Asp Ser Ser Arg
                565                 570                 575     
His Arg Asp Tyr Val Cys Phe Arg Gly Val Ser Gly Thr Lys Pro His
            580                 585                 590         
Ser Ala Ile Phe Cys His Asp Glu Asp Ser Ser Asp Gln Ser Asp Leu
        595                 600                 605             
Ser Arg Ala Ser Ser Val Gln Ser Ala His Gln Phe Ser Ser Asp Ser
    610                 615                 620                 
Ser Ser Ser Thr Thr Ser His Ser Cys Gln Ser Pro Glu Gly Arg Tyr
625                 630                 635                 640 
Ser Ala Leu Lys Thr Lys His Thr His Lys Glu Arg Gly Thr Asp Ser
                645                 650                 655     
Glu His Thr His Lys Ala His Leu Val Pro Glu Gly Thr Ser Lys Lys
            660                 665                 670         
Arg Ala Thr Arg Arg Thr Ser Ser Thr Asn Ser Ala Lys Thr Arg Ala
        675                 680                 685             
Arg Val Leu Ser Leu Asp Ser Gly Thr Val Ala Cys Leu Asn Asp Ser
    690                 695                 700                 
Asn Arg Leu Met Ala Pro Glu Ser Ile Lys Pro Leu Thr Thr Ser Lys
705                 710                 715                 720 
Ser Asp Leu Glu Ala Lys Glu Gly Glu Val Leu Asp Glu Leu Ser Leu
                725                 730                 735     
Leu Gly Arg Ala Ser Gln Leu Glu Thr Val Thr Arg Ser Arg Asn Ser
            740                 745                 750         
Leu Pro Asn Gln Val Ala Phe Pro Glu Gly Glu Glu Gln Asp Ala Val
        755                 760                 765             
Ser Gly Ala Ala Gln Ala Ser Glu Glu Ala Val Ser Phe Arg Arg Glu
    770                 775                 780                 
Arg Ser Thr Phe Arg Arg Gln Ala Val Arg Arg Arg His Asn Ala Gly
785                 790                 795                 800 
Ser Asn Pro Thr Pro Pro Thr Leu Leu Ile Gly Ser Pro Leu Ser Leu
                805                 810                 815     
Gln Asp Gly Gln Gln Gly Gln Gln Ser Thr Ala Gln Val Lys Val Gln
            820                 825                 830         
Ser Arg Pro Pro Ser Gln Ala Ala Val Leu Ser Ala Ser Ala Ser Leu
        835                 840                 845             
Leu Val Arg Asn Gly Ser Val His Leu Glu Ala Ser His Asp Asn Ala
    850                 855                 860                 
Ser Ala Val Gly Gly Ser Ser Leu His Asp Glu Leu Gly Lys Phe Ser
865                 870                 875                 880 
Ser Thr Leu Tyr Glu Thr Gly Gly Cys Asp Met Ser Leu Val Asn Phe
                885                 890                 895     
Glu Pro Ala Ala Arg Arg Ala Ser Asn Ile Cys Asp Thr Asp Ser His
            900                 905                 910         
Val Ser Ser Ser Thr Ser Val Arg Phe Tyr Pro His Asp Val Leu Ser
        915                 920                 925             
Leu Pro Gln Ile Arg Leu Asn Arg Leu Leu Thr Ile Asp Thr Asp Leu
    930                 935                 940                 
Leu Glu Gln Gln Asp Ile Asp Leu Ser Pro Asp Leu Ala Ala Thr Tyr
945                 950                 955                 960 
Gly Pro Thr Glu Glu Ala Ala Gln Lys Val Lys His Tyr Tyr Arg Phe
                965                 970                 975     
Trp Ile Leu Pro Gln Leu Trp Ile Gly Ile Asn Phe Asp Arg Leu Thr
            980                 985                 990         
Leu Leu Ala Leu Phe Asp Arg Asn Arg Glu Ile Leu Glu Asn Val Leu
        995                 1000                1005            
Ala Val Ile Leu Ala Ile Leu Val Ala Phe Leu Gly Ser Ile Leu Leu
    1010                1015                1020                
Ile Gln Gly Phe Phe Arg Asp Ile Trp Val Phe Gln Phe Cys Leu Val
1025                1030                1035                1040
Ile Ala Ser Cys Gln Tyr Ser Leu Leu Lys Ser Val Gln Pro Asp Ser
                1045                1050                1055    
Ser Ser Pro Arg His Gly His Asn Arg Ile Ile Ala Tyr Ser Arg Pro
            1060                1065                1070        
Val Tyr Phe Cys Ile Cys Cys Gly Leu Ile Trp Leu Leu Asp Tyr Gly
        1075                1080                1085            
Ser Arg Asn Leu Thr Ala Thr Lys Phe Lys Leu Tyr Gly Ile Thr Phe
    1090                1095                1100                
Thr Asn Pro Leu Val Phe Ile Ser Ala Arg Asp Leu Val Ile Val Phe
1105                1110                1115                1120
Thr Leu Cys Phe Pro Ile Val Phe Phe Ile Gly Leu Leu Pro Gln Val
                1125                1130                1135    
Asn Thr Phe Val Met Tyr Leu Cys Glu Gln Leu Asp Ile His Ile Phe
            1140                1145                1150        
Gly Gly Asn Ala Thr Thr Ser Leu Leu Ala Ala Leu Tyr Ser Phe Ile
        1155                1160                1165            
Cys Ser Ile Val Ala Val Ala Leu Leu Tyr Gly Leu Cys Tyr Gly Ala
    1170                1175                1180                
Leu Lys Asp Ser Trp Asp Gly Gln His Ile Pro Val Leu Phe Ser Ile
1185                1190                1195                1200
Phe Cys Gly Leu Leu Val Ala Val Ser Tyr His Leu Ser Arg Gln Ser
                1205                1210                1215    
Ser Asp Pro Ser Val Leu Phe Ser Leu Val Gln Ser Lys Ile Phe Pro
            1220                1225                1230        
Lys Thr Glu Glu Lys Asn Pro Glu Asp Pro Leu Ser Glu Val Lys Asp
        1235                1240                1245            
Pro Leu Pro Glu Lys Leu Arg Asn Ser Val Ser Glu Arg Leu Gln Ser
    1250                1255                1260                
Asp Leu Val Val Cys Ile Val Ile Gly Val Leu Tyr Phe Ala Ile His
1265                1270                1275                1280
Val Ser Thr Val Phe Thr Val Leu Gln Pro Ala Leu Lys Tyr Val Leu
                1285                1290                1295    
Tyr Thr Leu Val Gly Phe Val Gly Phe Val Thr His Tyr Val Leu Pro
            1300                1305                1310        
Gln Val Arg Lys Gln Leu Pro Trp His Cys Phe Ser His Pro Leu Leu
        1315                1320                1325            
Lys Thr Leu Glu Tyr Asn Gln Tyr Glu Val Arg Asn Ala Ala Thr Met
    1330                1335                1340                
Met Trp Phe Glu Lys Leu His Val Trp Leu Leu Phe Val Glu Lys Asn
1345                1350                1355                1360
Ile Ile Tyr Pro Leu Ile Val Leu Asn Glu Leu Ser Ser Ser Ala Glu
                1365                1370                1375    
Thr Ile Ala Ser Pro Lys Lys Leu Asn Thr Glu Leu Gly Ala Leu Met
            1380                1385                1390        
Ile Thr Val Ala Gly Leu Lys Leu Leu Arg Ser Ser Phe Ser Ser Pro
        1395                1400                1405            
Thr Tyr Gln Tyr Val Thr Val Ile Phe Thr Val Leu Phe Phe Lys Phe
    1410                1415                1420                
Asp Tyr Glu Ala Phe Ser Glu Thr Met Leu Leu Asp Leu Phe Phe Met
1425                1430                1435                1440
Ser Ile Leu Phe Asn Lys Leu Trp Glu Leu Leu Tyr Lys Leu Gln Phe
                1445                1450                1455    
Val Tyr Thr Tyr Ile Ala Pro Trp Gln Ile Thr Trp Gly Ser Ala Phe
            1460                1465                1470        
His Ala Phe Ala Gln Pro Phe Ala Val Pro His Ser Ala Met Leu Phe
        1475                1480                1485            
Ile Gln Ala Ala Val Ser Ala Phe Phe Ser Thr Pro Leu Asn Pro Phe
    1490                1495                1500                
Leu Gly Ser Ala Ile Phe Ile Thr Ser Tyr Val Arg Pro Val Lys Phe
1505                1510                1515                1520
Trp Glu Arg Asp Tyr Asn Thr Lys Arg Val Asp His Ser Asn Thr Arg
                1525                1530                1535    
Leu Ala Ser Gln Leu Asp Arg Asn Pro Gly Ser Asp Asp Asn Asn Leu
            1540                1545                1550        
Asn Ser Ile Phe Tyr Glu His Leu Thr Arg Ser Leu Gln His Ser Leu
        1555                1560                1565            
Cys Gly Asp Leu Leu Leu Gly Arg Trp Gly Asn Tyr Ser Thr Gly Asp
    1570                1575                1580                
Cys Phe Ile Leu Ala Ser Asp Tyr Leu Asn Ala Leu Val His Leu Ile
1585                1590                1595                1600
Glu Ile Gly Asn Gly Leu Val Thr Phe Gln Leu Arg Gly Leu Glu Phe
                1605                1610                1615    
Arg Gly Thr Tyr Cys Gln Gln Arg Glu Val Glu Ala Ile Thr Glu Gly
            1620                1625                1630        
Val Glu Glu Asp Glu Gly Phe Cys Cys Cys Glu Pro Gly His Ile Pro
        1635                1640                1645            
His Met Leu Ser Phe Asn Ala Ala Phe Ser Gln Arg Trp Leu Ala Trp
    1650                1655                1660                
Glu Val Ile Val Thr Lys Tyr Ile Leu Glu Gly Tyr Ser Ile Thr Asp
1665                1670                1675                1680
Asn Ser Ala Ala Ser Met Leu Gln Val Phe Asp Leu Arg Lys Val Leu
                1685                1690                1695    
Thr Thr Tyr Tyr Val Lys Gly Ile Ile Tyr Tyr Val Thr Thr Ser Ser
            1700                1705                1710        
Lys Leu Glu Glu Trp Leu Ala Asn Glu Thr Met Gln Glu Gly Leu Arg
        1715                1720                1725            
Leu Cys Ala Asp Arg Asn Tyr Val Asp Val Asp Pro Thr Phe Asn Pro
    1730                1735                1740                
Asn Ile Asp Glu Asp Tyr Asp His Arg Leu Ala Gly Ile Ser Arg Glu
1745                1750                1755                1760
Ser Phe Cys Val Ile Tyr Leu Asn Trp Ile Glu Tyr Cys Ser Ser Arg
                1765                1770                1775    
Arg Ala Lys Pro Val Asp Val Asp Lys Asp Ser Ser Leu Val Thr Leu
            1780                1785                1790        
Cys Tyr Gly Leu Cys Val Leu Gly Arg Arg Ala Leu Gly Thr Ala Ser
        1795                1800                1805            
His His Met Ser Ser Asn Leu Glu Ser Phe Leu Tyr Gly Leu His Ala
    1810                1815                1820                
Leu Phe Lys Gly Asp Phe Arg Ile Ser Ser Ile Arg Asp Glu Trp Ile
1825                1830                1835                1840
Phe Ala Asp Met Glu Leu Leu Arg Lys Val Val Val Pro Gly Ile Arg
                1845                1850                1855    
Met Ser Ile Lys Leu His Gln Asp His Phe Thr Ser Pro Asp Glu Tyr
            1860                1865                1870        
Asp Asp Pro Thr Val Leu Tyr Glu Ala Ile Val Ser His Glu Lys Asn
        1875                1880                1885            
Leu Val Ile Ala His Glu Gly Asp Pro Ala Trp Arg Ser Ala Val Leu
    1890                1895                1900                
Ala Asn Ser Pro Ser Leu Leu Ala Leu Arg His Val Met Asp Asp Gly
1905                1910                1915                1920
Thr Asn Glu Tyr Lys Ile Ile Met Leu Asn Arg Arg Tyr Leu Ser Phe
                1925                1930                1935    
Arg Val Ile Lys Val Asn Lys Glu Cys Val Arg Gly Leu Trp Ala Gly
            1940                1945                1950        
Gln Gln Gln Glu Leu Val Phe Leu Arg Asn Arg Asn Pro Glu Arg Gly
        1955                1960                1965            
Ser Ile Gln Asn Ala Lys Gln Ala Leu Arg Asn Met Ile Asn Ser Ser
    1970                1975                1980                
Cys Asp Gln Pro Ile Gly Tyr Pro Ile Phe Val Ser Pro Leu Thr Thr
1985                1990                1995                2000
Ser Tyr Ser Asp Ser His Glu Gln Leu Lys Asp Ile Leu Gly Gly Pro
                2005                2010                2015    
Ile Ser Leu Gly Asn Ile Arg Asn Phe Ile Val Ser Thr Trp His Arg
            2020                2025                2030        
Leu Arg Lys Gly Cys Gly Ala Gly Cys Asn Ser Gly Gly Asn Ile Glu
        2035                2040                2045            
Asp Ser Asp Thr Gly Gly Gly Thr Ser Cys Thr Gly Asn Asn Ala Thr
    2050                2055                2060                
Thr Ala Asn Asn Pro His Ser Asn Val Thr Gln Gly Ser Ile Gly Asn
2065                2070                2075                2080
Pro Gly Gln Gly Ser Gly Thr Gly Leu His Pro Pro Val Thr Ser Tyr
                2085                2090                2095    
Pro Pro Thr Leu Gly Thr Ser His Ser Ser His Ser Val Gln Ser Gly
            2100                2105                2110        
Leu Val Arg Gln Ser Pro Ala Arg Ala Ser Val Ala Ser Gln Ser Ser
        2115                2120                2125            
Tyr Cys Tyr Ser Ser Arg His Ser Ser Leu Arg Met Ser Thr Thr Gly
    2130                2135                2140                
Phe Val Pro Cys Arg Arg Ser Ser Thr Ser Gln Ile Ser Leu Arg Asn
2145                2150                2155                2160
Leu Pro Ser Ser Ile Gln Ser Arg Leu Ser Met Val Asn Gln Met Glu
                2165                2170                2175    
Pro Ser Gly Gln Ser Gly Leu Ala Cys Val Gln His Gly Leu Pro Ser
            2180                2185                2190        
Ser Ser Ser Ser Ser Gln Ser Ile Pro Ala Cys Lys His His Thr Leu
        2195                2200                2205            
Val Gly Phe Leu Ala Thr Glu Gly Gly Gln Ser Ser Ala Thr Asp Ala
    2210                2215                2220                
Gln Pro Gly Asn Thr Leu Ser Pro Ala Asn Asn Ser His Ser Lys Lys
2225                2230                2235                2240
Ala Glu Val Ile Tyr Arg Val Gln Ile Val Asp Pro Ser Gln Ile Leu
                2245                2250                2255    
Glu Gly Ile Asn Leu Ser Lys Arg Lys Glu Leu Gln Trp Pro Asp Glu
            2260                2265                2270        
Gly Ile Arg Leu Lys Ala Gly Arg Asn Ser Trp Lys Asp Trp Ser Pro
        2275                2280                2285            
Gln Glu Gly Met Glu Gly His Val Ile His Arg Trp Val Pro Cys Ser
    2290                2295                2300                
Arg Asp Pro Gly Thr Arg Ser His Ile Asp Lys Ala Val Leu Leu Val
2305                2310                2315                2320
Gln Ile Asp Asp Lys Tyr Val Thr Val Ile Glu Thr Gly Val Leu Glu
                2325                2330                2335    
Leu Gly Ala Glu Val
            2340    


<210> 9269
<211> 474
<212> PRT
<213> Homo sapiens

<400> 9269
Met Trp Arg Val Arg Lys Arg Gly Tyr Phe Gly Ile Trp Ser Phe Pro
 1               5                  10                  15      
Leu Ile Ile Ala Ala Val Cys Ala Gln Ser Val Asn Asp Pro Ser Asn
            20                  25                  30          
Met Ser Leu Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr Asp
        35                  40                  45              
Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Ala Val Gly Met
    50                  55                  60                  
Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met Asp
65                  70                  75                  80  
Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ala Trp Arg Asp Lys Arg Leu
                85                  90                  95      
Ser Tyr Asn Val Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val Ala
            100                 105                 110         
Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys Ser
        115                 120                 125             
Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His Pro
    130                 135                 140                 
Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala Cys
145                 150                 155                 160 
Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr Leu
                165                 170                 175     
Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr Trp
            180                 185                 190         
Arg Gly Asp Asp Asn Ala Val Thr Gly Val Thr Lys Ile Glu Leu Pro
        195                 200                 205             
Gln Phe Ser Ile Val Asp Tyr Lys Leu Ile Thr Lys Lys Val Val Phe
    210                 215                 220                 
Ser Thr Gly Ser Tyr Pro Arg Leu Ser Leu Ser Phe Lys Leu Lys Arg
225                 230                 235                 240 
Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu Ile
                245                 250                 255     
Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser Ala
            260                 265                 270         
Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Ile
        275                 280                 285             
Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys Ala
    290                 295                 300                 
Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Met Ala Leu
305                 310                 315                 320 
Leu Glu Tyr Ala Leu Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro Gln
                325                 330                 335     
Arg Gln Lys Lys Ala Ala Glu Lys Ala Ala Ser Ala Asn Asn Glu Lys
            340                 345                 350         
Met Arg Leu Asp Val Asn Lys Met Asp Pro His Glu Asn Ile Leu Leu
        355                 360                 365             
Ser Thr Leu Glu Ile Lys Asn Glu Met Ala Thr Ser Glu Ala Val Met
    370                 375                 380                 
Gly Leu Gly Asp Pro Arg Ser Thr Met Leu Ala Tyr Asp Ala Ser Ser
385                 390                 395                 400 
Ile Gln Tyr Arg Lys Ala Gly Leu Pro Arg His Ser Phe Gly Arg Asn
                405                 410                 415     
Ala Leu Glu Arg His Val Ala Gln Lys Lys Ser Arg Leu Arg Arg Arg
            420                 425                 430         
Ala Ser Gln Leu Lys Ile Thr Ile Pro Asp Leu Thr Asp Val Asn Ala
        435                 440                 445             
Ile Asp Arg Trp Ser Arg Ile Phe Phe Pro Val Val Phe Ser Phe Phe
    450                 455                 460                 
Asn Ile Val Tyr Trp Leu Tyr Tyr Val Asn
465                 470                 


<210> 9270
<211> 512
<212> PRT
<213> Homo sapiens

<400> 9270
Met Trp Arg Val Arg Lys Arg Gly Tyr Phe Gly Ile Trp Ser Phe Pro
 1               5                  10                  15      
Leu Ile Ile Ala Ala Val Cys Ala Gln Ser Val Asn Asp Pro Ser Asn
            20                  25                  30          
Met Ser Leu Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr Asp
        35                  40                  45              
Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Ala Val Gly Met
    50                  55                  60                  
Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met Asp
65                  70                  75                  80  
Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ala Trp Arg Asp Lys Arg Leu
                85                  90                  95      
Ser Tyr Asn Val Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val Ala
            100                 105                 110         
Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys Ser
        115                 120                 125             
Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His Pro
    130                 135                 140                 
Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala Cys
145                 150                 155                 160 
Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr Leu
                165                 170                 175     
Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr Trp
            180                 185                 190         
Arg Gly Asp Asp Asn Ala Val Thr Gly Val Thr Lys Ile Glu Leu Pro
        195                 200                 205             
Gln Phe Ser Ile Val Asp Tyr Lys Leu Ile Thr Lys Lys Val Val Phe
    210                 215                 220                 
Ser Thr Gly Ser Tyr Pro Arg Leu Ser Leu Ser Phe Lys Leu Lys Arg
225                 230                 235                 240 
Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu Ile
                245                 250                 255     
Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser Ala
            260                 265                 270         
Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Ile
        275                 280                 285             
Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys Ala
    290                 295                 300                 
Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Met Ala Leu
305                 310                 315                 320 
Leu Glu Tyr Ala Leu Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro Gln
                325                 330                 335     
Arg Gln Lys Lys Ala Ala Glu Lys Ala Ala Ser Ala Asn Asn Glu Lys
            340                 345                 350         
Met Arg Leu Asp Val Asn Lys Ile Phe Tyr Lys Asp Ile Lys Gln Asn
        355                 360                 365             
Gly Thr Gln Tyr Arg Ser Leu Trp Asp Pro Thr Gly Asn Leu Ser Pro
    370                 375                 380                 
Thr Arg Arg Thr Thr Asn Tyr Asp Phe Ser Leu Tyr Thr Met Asp Pro
385                 390                 395                 400 
His Glu Asn Ile Leu Leu Ser Thr Leu Glu Ile Lys Asn Glu Met Ala
                405                 410                 415     
Thr Ser Glu Ala Val Met Gly Leu Gly Asp Pro Arg Ser Thr Met Leu
            420                 425                 430         
Ala Tyr Asp Ala Ser Ser Ile Gln Tyr Arg Lys Ala Gly Leu Pro Arg
        435                 440                 445             
His Ser Phe Gly Arg Asn Ala Leu Glu Arg His Val Ala Gln Lys Lys
    450                 455                 460                 
Ser Arg Leu Arg Arg Arg Ala Ser Gln Leu Lys Ile Thr Ile Pro Asp
465                 470                 475                 480 
Leu Thr Asp Val Asn Ala Ile Asp Arg Trp Ser Arg Ile Phe Phe Pro
                485                 490                 495     
Val Val Phe Ser Phe Phe Asn Ile Val Tyr Trp Leu Tyr Tyr Val Asn
            500                 505                 510         


<210> 9271
<211> 210
<212> PRT
<213> Homo sapiens

<400> 9271
Met Glu Asp Ser Pro Leu Pro Asp Leu Arg Asp Ile Glu Leu Lys Leu
 1               5                  10                  15      
Gly Arg Lys Val Pro Glu Ser Leu Val Arg Ser Leu Arg Gly Glu Glu
            20                  25                  30          
Pro Val Pro Arg Glu Arg Asp Arg Asp Pro Cys Gly Gly Ser Gly Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys Ser Ser Gly Ser Ser
    50                  55                  60                  
Tyr Cys Ser Phe Pro Pro Ser Leu Ser Ser Ser Ser Ser Ser Ser Pro
65                  70                  75                  80  
Thr Ser Gly Ser Pro Arg Gly Ser His Ser Ser Ala Leu Glu Arg Leu
                85                  90                  95      
Glu Thr Lys Leu His Leu Leu Arg Gln Glu Met Val Asn Leu Arg Ala
            100                 105                 110         
Thr Asp Val Arg Leu Met Arg Gln Leu Leu Val Ile Asn Glu Ser Ile
        115                 120                 125             
Glu Ser Ile Lys Trp Met Ile Glu Glu Lys Ala Thr Ile Thr Ser Arg
    130                 135                 140                 
Gly Ser Ser Leu Ser Ser Ser Leu Cys Ser Leu Leu Glu Ser Gln Ser
145                 150                 155                 160 
Thr Ser Tyr Val Ala Ala Thr Thr Ala Tyr Thr Met Ala Val Met Gly
                165                 170                 175     
Trp Met Ala Phe Pro Trp Glu Val Ile Trp Thr Arg Trp Arg Met Met
            180                 185                 190         
Ser Gln Ala Ile Arg Pro Leu Gln Thr Trp Thr Asn Ser Val Thr Ala
        195                 200                 205             
Pro Ser
    210 


<210> 9272
<211> 231
<212> PRT
<213> Homo sapiens

<400> 9272
Met Glu Asp Ser Pro Leu Pro Asp Leu Arg Asp Ile Glu Leu Lys Leu
 1               5                  10                  15      
Gly Arg Lys Val Pro Glu Ser Leu Val Arg Ser Leu Arg Gly Glu Glu
            20                  25                  30          
Pro Val Pro Arg Glu Arg Asp Arg Asp Pro Cys Gly Gly Ser Gly Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys Ser Ser Gly Ser Ser
    50                  55                  60                  
Tyr Cys Ser Phe Pro Pro Ser Leu Ser Ser Ser Ser Ser Ser Ser Pro
65                  70                  75                  80  
Thr Ser Gly Ser Pro Arg Gly Ser His Ser Ser Ala Leu Glu Arg Leu
                85                  90                  95      
Glu Thr Lys Leu His Leu Leu Arg Gln Glu Met Val Asn Leu Arg Ala
            100                 105                 110         
Thr Asp Val Arg Leu Met Arg Gln Leu Leu Val Ile Asn Glu Ser Ile
        115                 120                 125             
Glu Ser Ile Lys Trp Met Ile Glu Glu Lys Ala Thr Ile Thr Ser Arg
    130                 135                 140                 
Gly Ser Ser Leu Ser Gly Ser Leu Cys Ser Leu Leu Glu Ser Gln Ser
145                 150                 155                 160 
Thr Ser Leu Arg Gly Ser Tyr Asn Ser Leu His Asp Gly Ser Asp Gly
                165                 170                 175     
Leu Asp Gly Ile Ser Val Gly Ser Tyr Leu Asp Thr Leu Ala Asp Asp
            180                 185                 190         
Val Pro Gly His Gln Thr Pro Ser Asp Leu Asp Gln Phe Ser Asp Ser
        195                 200                 205             
Ser Leu Ile Glu Asp Ser Gln Ala Leu His Lys Arg Pro Lys Leu Asp
    210                 215                 220                 
Ser Glu Tyr Tyr Cys Phe Gly
225                 230     


<210> 9273
<211> 206
<212> PRT
<213> Homo sapiens

<400> 9273
Met Glu Asp Ser Pro Leu Pro Asp Leu Arg Asp Ile Glu Leu Lys Leu
 1               5                  10                  15      
Gly Arg Lys Val Pro Glu Ser Leu Val Arg Ser Leu Arg Gly Glu Glu
            20                  25                  30          
Pro Val Pro Arg Glu Arg Asp Arg Asp Pro Cys Gly Gly Ser Gly Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Gly Cys Ser Ser Ser Ser Ser Tyr Cys Ser
    50                  55                  60                  
Phe Pro Pro Ser Leu Ser Ser Ser Ser Ser Ser Ser Pro Thr Ser Gly
65                  70                  75                  80  
Ser Pro Arg Gly Ser His Ser Ser Ala Leu Glu Arg Leu Glu Thr Lys
                85                  90                  95      
Leu His Leu Leu Arg Gln Glu Met Val Asn Leu Arg Ala Thr Asp Val
            100                 105                 110         
Arg Leu Met Arg Gln Leu Leu Val Ile Asn Glu Ser Ile Glu Ser Ile
        115                 120                 125             
Lys Trp Met Ile Glu Glu Lys Ala Thr Ile Thr Ser Arg Gly Ser Ser
    130                 135                 140                 
Leu Ser Gly Ser Leu Cys Ser Leu Leu Glu Ser Gln Ser Thr Tyr Val
145                 150                 155                 160 
Ala Ala Thr Thr Ala Tyr Thr Met Ala Val Met Gly Trp Met Ala Phe
                165                 170                 175     
Pro Trp Glu Val Ile Trp Thr Arg Trp Arg Met Met Ser Gln Ala Ile
            180                 185                 190         
Arg Pro Leu Gln Thr Trp Thr Asn Ser Val Thr Ala Pro Ser
        195                 200                 205     


<210> 9274
<211> 334
<212> PRT
<213> Homo sapiens

<400> 9274
Met Glu Pro Gly Pro Thr Ala Ala Gln Arg Arg Cys Ser Leu Pro Pro
 1               5                  10                  15      
Trp Leu Pro Leu Gly Leu Leu Leu Trp Ser Gly Leu Ala Leu Gly Ala
            20                  25                  30          
Leu Pro Phe Gly Ser Ser Pro His Arg Val Phe His Asp Leu Leu Ser
        35                  40                  45              
Glu Gln Gln Leu Leu Glu Val Glu Asp Leu Ser Leu Ser Leu Leu Gln
    50                  55                  60                  
Gly Gly Gly Leu Gly Pro Leu Ser Leu Pro Pro Asp Leu Pro Asp Leu
65                  70                  75                  80  
Asp Pro Glu Cys Arg Glu Leu Leu Leu Asp Phe Ala Asn Ser Ser Ala
                85                  90                  95      
Glu Leu Thr Gly Cys Leu Val Arg Ser Ala Arg Pro Val Arg Leu Cys
            100                 105                 110         
Gln Thr Cys Tyr Pro Leu Phe Gln Gln Val Val Ser Lys Met Asp Asn
        115                 120                 125             
Ile Ser Arg Ala Ala Gly Asn Thr Ser Glu Ser Gln Ser Cys Ala Arg
    130                 135                 140                 
Ser Leu Leu Met Ala Asp Arg Met Gln Ile Val Val Ile Leu Ser Glu
145                 150                 155                 160 
Phe Phe Asn Thr Thr Trp Gln Glu Ala Asn Cys Ala Asn Cys Leu Thr
                165                 170                 175     
Asn Asn Ser Glu Glu Leu Ser Asn Ser Thr Val Tyr Phe Leu Asn Leu
            180                 185                 190         
Phe Asn His Thr Leu Thr Cys Phe Glu His Asn Leu Gln Gly Asn Ala
        195                 200                 205             
His Ser Leu Leu Gln Thr Lys Asn Tyr Ser Glu Val Cys Lys Asn Cys
    210                 215                 220                 
Arg Glu Ala Tyr Lys Thr Leu Ser Ser Leu Tyr Ser Glu Met Gln Lys
225                 230                 235                 240 
Met Asn Glu Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu Cys Ile
                245                 250                 255     
Asp Val Glu Asp Ala Met Asn Ile Thr Arg Lys Leu Trp Ser Arg Thr
            260                 265                 270         
Phe Asn Cys Ser Val Pro Cys Ser Asp Thr Val Pro Val Ile Ala Val
        275                 280                 285             
Ser Val Phe Ile Leu Phe Leu Pro Val Val Phe Tyr Leu Ser Ser Phe
    290                 295                 300                 
Leu His Ser Glu Gln Lys Lys Arg Lys Leu Ile Leu Pro Lys Arg Leu
305                 310                 315                 320 
Lys Ser Ser Thr Ser Phe Ala Asn Ile Gln Glu Asn Ser Asn
                325                 330                 


<210> 9275
<211> 334
<212> PRT
<213> Homo sapiens

<400> 9275
Met Glu Pro Gly Pro Thr Ala Ala Gln Arg Arg Cys Ser Leu Pro Pro
 1               5                  10                  15      
Trp Leu Pro Leu Gly Leu Leu Leu Trp Ser Gly Leu Ala Leu Gly Ala
            20                  25                  30          
Leu Pro Phe Gly Ser Ser Pro His Arg Val Phe His Asp Leu Leu Ser
        35                  40                  45              
Glu Gln Gln Leu Leu Glu Val Glu Asp Leu Ser Leu Ser Leu Leu Gln
    50                  55                  60                  
Gly Gly Gly Leu Gly Pro Leu Ser Leu Pro Pro Asp Leu Pro Asp Leu
65                  70                  75                  80  
Asp Pro Glu Cys Arg Glu Pro Leu Leu Asp Phe Ala Asn Ser Ser Ala
                85                  90                  95      
Glu Leu Thr Gly Cys Leu Val Arg Ser Ala Arg Pro Val Arg Leu Cys
            100                 105                 110         
Gln Thr Cys Tyr Pro Leu Phe Gln Gln Val Val Ser Lys Met Asp Asn
        115                 120                 125             
Ile Ser Arg Ala Ala Gly Asn Thr Ser Glu Ser Gln Ser Cys Ala Arg
    130                 135                 140                 
Ser Leu Leu Met Ala Asp Arg Met Gln Ile Val Val Ile Leu Ser Glu
145                 150                 155                 160 
Phe Phe Asn Thr Thr Trp Gln Glu Ala Asn Cys Ala Asn Cys Leu Thr
                165                 170                 175     
Asn Asn Ser Glu Glu Leu Ser Asn Ser Thr Val Tyr Phe Leu Asn Leu
            180                 185                 190         
Phe Asn His Thr Leu Thr Cys Phe Glu His Asn Leu Gln Gly Asn Ala
        195                 200                 205             
His Ser Leu Leu Gln Thr Lys Asn Tyr Ser Glu Val Cys Lys Asn Cys
    210                 215                 220                 
Arg Glu Ala Tyr Lys Thr Leu Ser Ser Leu Tyr Ser Glu Met Gln Lys
225                 230                 235                 240 
Met Asn Glu Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu Cys Ile
                245                 250                 255     
Asp Val Glu Asp Ala Met Asn Ile Thr Arg Lys Leu Trp Ser Arg Thr
            260                 265                 270         
Phe Asn Cys Ser Val Pro Cys Ser Asp Thr Val Pro Val Ile Ala Val
        275                 280                 285             
Ser Val Phe Ile Leu Phe Leu Pro Val Val Phe Tyr Leu Ser Ser Phe
    290                 295                 300                 
Leu His Ser Glu Gln Lys Lys Arg Lys Leu Ile Leu Pro Lys Arg Leu
305                 310                 315                 320 
Lys Ser Ser Thr Ser Phe Ala Asn Ile Gln Glu Asn Ser Asn
                325                 330                 


<210> 9276
<211> 245
<212> PRT
<213> Homo sapiens

<400> 9276
Met Thr Leu Val Ile Leu Leu Val Glu Leu Gly Gly Ser Gln Ala Arg
 1               5                  10                  15      
Phe Pro Leu Phe Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala
            20                  25                  30          
Ala Leu Leu Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Leu
        35                  40                  45              
Gln Phe Leu Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Ile
    50                  55                  60                  
Val Phe Ser Gly Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Thr Trp
65                  70                  75                  80  
Thr Arg Ala Arg Pro Gly Glu Ile Thr Asp Tyr Met Ala Ser Glu Leu
                85                  90                  95      
Gly Leu Leu Lys Val Leu Glu Thr Phe Val Ala Cys Leu Ile Phe Val
            100                 105                 110         
Phe Ile Asn Ser Pro Tyr Val Tyr His Asn Arg Pro Ala Leu Glu Trp
        115                 120                 125             
Cys Val Ala Val Tyr Ala Leu Cys Phe Val Leu Ala Ala Leu Thr Val
    130                 135                 140                 
Leu Leu Ser Leu Gly His Cys Thr Asn Met Leu Pro Ile Arg Phe Pro
145                 150                 155                 160 
Ser Phe Leu Leu Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr
                165                 170                 175     
Ala Leu Val Leu Trp Pro Leu Tyr Gln Phe Asn Glu Lys Tyr Gly Val
            180                 185                 190         
Gln Pro Trp Gln Thr Arg Asp Val Ser Cys Ser Asp Arg Asn Pro Tyr
        195                 200                 205             
Leu Val Cys Ile Trp Asp Arg Arg Leu Ala Val Thr Asn Leu Thr Ala
    210                 215                 220                 
Val Asn Leu Leu Ala Tyr Val Gly Asp Leu Val Tyr Ser Ala His Leu
225                 230                 235                 240 
Val Phe Val Lys Val
                245 


<210> 9277
<211> 969
<212> PRT
<213> Homo sapiens

<400> 9277
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu
 1               5                  10                  15      
Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val
            20                  25                  30          
Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser
        35                  40                  45              
Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn
    50                  55                  60                  
Gly Thr Pro Gly Lys Ile Leu Lys Lys Phe Lys Pro Arg Phe Asn Val
65                  70                  75                  80  
Thr Leu Ser Leu Leu Pro Ser Asn Glu Thr Glu Lys Thr Lys Ile Thr
                85                  90                  95      
Ile Val Lys Thr Phe Asn Ala Ser Gly Val Lys Pro Gln Arg Asn Ile
            100                 105                 110         
Cys Asn Leu Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu
        115                 120                 125             
Ile Met Phe Gln Tyr Asp Lys Glu Ser Thr Val Pro Gln Asn Gln His
    130                 135                 140                 
Ile Thr Asn Gly Thr Leu Thr Gly Val Leu Ser Leu Ser Glu Leu Lys
145                 150                 155                 160 
Arg Ser Glu Leu Asn Lys Thr Leu Gln Thr Leu Ser Glu Thr Tyr Phe
                165                 170                 175     
Ile Met Cys Ala Thr Ala Glu Ala Gln Ser Thr Leu Asn Cys Thr Phe
            180                 185                 190         
Thr Ile Lys Leu Asn Asn Thr Met Asn Ala Cys Ala Val Ile Ala Ala
        195                 200                 205             
Leu Glu Arg Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val
    210                 215                 220                 
Arg Ile Pro Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys
225                 230                 235                 240 
Asp Leu Gln Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro
                245                 250                 255     
Pro Phe Ser Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Thr Val
            260                 265                 270         
Leu Ser Gln Val Pro Lys Ala Thr Ser Phe Ala Glu Pro Pro Asp Tyr
        275                 280                 285             
Ser Pro Val Thr His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro
    290                 295                 300                 
Leu Ser Pro Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp
305                 310                 315                 320 
Met Pro Pro Gln Ser Glu Thr Ile Ser Ser Pro Met Pro Gln Thr His
                325                 330                 335     
Val Ser Gly Thr Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Thr
            340                 345                 350         
Val Ser Ala Pro Ala Asn Val Asn Thr Thr Ser Ala Pro Pro Val Gln
        355                 360                 365             
Thr Asp Ile Val Asn Thr Ser Ser Ile Ser Asp Leu Glu Asn Gln Val
    370                 375                 380                 
Leu Gln Met Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu
385                 390                 395                 400 
Ala Gly Glu Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro
                405                 410                 415     
Asp Met Leu Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp
            420                 425                 430         
Ile Gly Leu Gln Leu Asn Phe Ser Asn Thr Thr Ile Ser Leu Thr Ser
        435                 440                 445             
Pro Ser Leu Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn
    450                 455                 460                 
Thr Thr Thr Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu
465                 470                 475                 480 
Glu Thr Gln Ala Pro Glu Asn Ser Ile Gly Thr Ile Thr Leu Pro Ser
                485                 490                 495     
Ser Leu Met Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg
            500                 505                 510         
Val Gln Phe Asn Phe Phe Glu Thr Pro Ala Leu Phe Gln Asp Pro Ser
        515                 520                 525             
Leu Glu Asn Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala
    530                 535                 540                 
Asn Leu Thr Val Arg Asn Leu Thr Arg Asn Val Thr Val Thr Leu Lys
545                 550                 555                 560 
His Ile Asn Pro Ser Gln Asp Glu Leu Thr Val Arg Cys Val Phe Trp
                565                 570                 575     
Asp Leu Gly Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys
            580                 585                 590         
Ser Val Lys Asp Arg Arg Leu Asn Glu Thr Ile Cys Thr Cys Ser His
        595                 600                 605             
Leu Thr Ser Phe Gly Val Leu Leu Asp Leu Ser Arg Thr Ser Val Leu
    610                 615                 620                 
Pro Ala Gln Met Met Ala Leu Thr Phe Ile Thr Tyr Ile Gly Cys Gly
625                 630                 635                 640 
Leu Ser Ser Ile Phe Leu Ser Val Thr Leu Val Thr Tyr Ile Ala Phe
                645                 650                 655     
Glu Lys Ile Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys
            660                 665                 670         
Ala Ala Leu Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile
        675                 680                 685             
Ala Leu Tyr Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu
    690                 695                 700                 
His Tyr Phe Leu Leu Val Ser Phe Thr Trp Met Gly Leu Glu Ala Phe
705                 710                 715                 720 
His Met Tyr Leu Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Lys
                725                 730                 735     
Tyr Ile Leu Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val
            740                 745                 750         
Val Thr Ile Ile Leu Thr Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser
        755                 760                 765             
Tyr Gly Lys Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn
    770                 775                 780                 
Asn Asn Ala Val Phe Tyr Ile Thr Val Val Gly Tyr Phe Cys Val Ile
785                 790                 795                 800 
Phe Leu Leu Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys
                805                 810                 815     
Arg Ile Lys Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Thr Ser Ile
            820                 825                 830         
Gln Asp Leu Arg Ser Ile Ala Gly Leu Thr Phe Leu Leu Gly Ile Thr
        835                 840                 845             
Trp Gly Phe Ala Phe Phe Ala Trp Gly Pro Val Asn Val Thr Phe Met
    850                 855                 860                 
Tyr Leu Phe Ala Ile Phe Asn Thr Leu Gln Gly Phe Phe Ile Phe Ile
865                 870                 875                 880 
Phe Tyr Cys Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr
                885                 890                 895     
Leu Cys Cys Gly Lys Leu Arg Leu Ala Glu Asn Ser Gly Asn Ala Ser
            900                 905                 910         
Thr Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys
        915                 920                 925             
Leu His Asp Phe Thr Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp
    930                 935                 940                 
Ser Cys Asn Gly Lys Gly Arg Met Ala Leu Arg Arg Thr Ser Lys Arg
945                 950                 955                 960 
Gly Ser Leu His Phe Ile Glu Gln Met
                965                 


<210> 9278
<211> 3501
<212> PRT
<213> Homo sapiens

<400> 9278
Met Gly Ile Lys Ser Gly Phe Thr Phe Trp Asn Leu Val Phe Leu Leu
 1               5                  10                  15      
Thr Val Ser Cys Val Lys Gly Phe Ile Tyr Thr Cys Gly Gly Thr Leu
            20                  25                  30          
Lys Gly Leu Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro Tyr Gly Tyr
        35                  40                  45              
Pro Asn Gly Ala Asn Cys Thr Trp Val Ile Ile Ala Glu Glu Arg Asn
    50                  55                  60                  
Arg Ile Gln Ile Val Phe Gln Ser Phe Ala Leu Glu Glu Glu Tyr Asp
65                  70                  75                  80  
Tyr Leu Ser Leu Tyr Asp Gly His Pro His Pro Thr Asn Phe Arg Thr
                85                  90                  95      
Arg Leu Thr Gly Phe His Leu Pro Pro Pro Val Thr Ser Thr Lys Ser
            100                 105                 110         
Val Phe Ser Leu Arg Leu Thr Ser Asp Phe Ala Val Ser Ala His Gly
        115                 120                 125             
Phe Lys Val Tyr Tyr Glu Glu Leu Gln Ser Ser Ser Cys Gly Asn Pro
    130                 135                 140                 
Gly Val Pro Pro Lys Gly Val Leu Tyr Gly Thr Arg Phe Asp Val Gly
145                 150                 155                 160 
Asp Lys Ile Arg Tyr Ser Cys Val Thr Gly Tyr Ile Leu Asp Gly His
                165                 170                 175     
Pro Gln Leu Thr Cys Ile Ala Asn Ser Val Asn Thr Ala Ser Trp Asp
            180                 185                 190         
Phe Pro Val Pro Ile Cys Arg Ala Glu Asp Ala Cys Gly Gly Thr Met
        195                 200                 205             
Arg Gly Ser Ser Gly Ile Ile Ser Ser Pro Ser Phe Pro Asn Glu Tyr
    210                 215                 220                 
His Asn Asn Ala Asp Cys Thr Trp Thr Ile Val Ala Glu Pro Gly Asp
225                 230                 235                 240 
Thr Ile Ser Leu Ile Phe Thr Asp Phe Gln Met Glu Glu Lys Tyr Asp
                245                 250                 255     
Tyr Leu Glu Ile Glu Gly Ser Glu Pro Pro Thr Ile Trp Leu Ser Gly
            260                 265                 270         
Met Asn Ile Pro Pro Pro Ile Ile Ser Asn Lys Asn Trp Leu Arg Leu
        275                 280                 285             
His Phe Val Thr Asp Ser Asn His Arg Tyr Arg Gly Phe Ser Ala Pro
    290                 295                 300                 
Tyr Gln Val Lys Lys Ala Ile Asp Phe Lys Ser Arg Gly Phe Lys Leu
305                 310                 315                 320 
Phe Pro Gly Lys Asp Asn Ser Asn Lys Phe Ser Ile Leu Asn Glu Gly
                325                 330                 335     
Gly Ile Lys Thr Ala Ser Asn Leu Cys Pro Asp Pro Gly Glu Pro Glu
            340                 345                 350         
Asn Gly Lys Arg Ile Gly Ser Asp Phe Ser Leu Gly Ser Thr Val Gln
        355                 360                 365             
Phe Ser Cys Asp Glu Asp Tyr Val Leu Gln Gly Ala Lys Ser Ile Thr
    370                 375                 380                 
Cys Gln Arg Ile Ala Glu Val Phe Ala Ala Trp Ser Asp His Arg Pro
385                 390                 395                 400 
Val Cys Lys Val Lys Thr Cys Gly Ser Asn Leu Gln Gly Pro Ser Gly
                405                 410                 415     
Thr Phe Thr Ser Pro Asn Phe Pro Phe Gln Tyr Asp Ser Asn Ala Gln
            420                 425                 430         
Cys Val Trp Val Ile Thr Ala Val Asn Thr Asn Lys Val Ile Gln Ile
        435                 440                 445             
Asn Phe Glu Glu Phe Asp Leu Glu Ile Gly Tyr Asp Thr Leu Thr Ile
    450                 455                 460                 
Gly Asp Gly Gly Glu Val Gly Asp Pro Arg Thr Val Leu Gln Val Leu
465                 470                 475                 480 
Thr Gly Ser Phe Val Pro Asp Leu Ile Val Ser Met Ser Ser Gln Met
                485                 490                 495     
Trp Leu His Leu Gln Thr Asp Glu Ser Val Gly Ser Val Gly Phe Lys
            500                 505                 510         
Val Asn Tyr Lys Glu Ile Glu Lys Glu Ser Cys Gly Asp Pro Gly Thr
        515                 520                 525             
Pro Leu Tyr Gly Ile Arg Glu Gly Asp Gly Phe Ser Asn Arg Asp Val
    530                 535                 540                 
Leu Arg Phe Glu Cys Gln Phe Gly Phe Glu Leu Ile Gly Glu Lys Ser
545                 550                 555                 560 
Ile Val Cys Gln Glu Asn Asn Gln Trp Ser Ala Asn Ile Pro Ile Cys
                565                 570                 575     
Ile Phe Pro Cys Leu Ser Asn Phe Thr Ala Pro Met Gly Thr Val Leu
            580                 585                 590         
Ser Pro Asp Tyr Pro Glu Gly Tyr Gly Asn Asn Leu Asn Cys Ile Trp
        595                 600                 605             
Thr Ile Ile Ser Asp Pro Gly Ser Arg Ile His Leu Ser Phe Asn Asp
    610                 615                 620                 
Phe Asp Leu Glu Ser Gln Phe Asp Phe Leu Ala Val Lys Asp Gly Asp
625                 630                 635                 640 
Ser Pro Glu Ser Pro Ile Leu Gly Thr Phe Thr Gly Ala Glu Val Pro
                645                 650                 655     
Ser His Leu Thr Ser Asn Ser His Ile Leu Arg Leu Glu Phe Gln Ala
            660                 665                 670         
Asp His Ser Met Ser Gly Arg Gly Phe Asn Ile Thr Tyr Asn Thr Phe
        675                 680                 685             
Gly His Asn Glu Cys Pro Asp Pro Gly Ile Pro Ile Asn Ala Arg Arg
    690                 695                 700                 
Phe Gly Asp Asn Phe Gln Leu Gly Ser Ser Ile Ser Val Ile Cys Glu
705                 710                 715                 720 
Glu Gly Phe Ile Lys Thr Gln Gly Thr Glu Thr Ile Thr Cys Ile Leu
                725                 730                 735     
Met Asp Gly Lys Val Met Trp Ser Gly Leu Ile Pro Lys Cys Gly Ala
            740                 745                 750         
Pro Cys Gly Gly His Phe Ser Ala Pro Ser Gly Val Ile Leu Ser Pro
        755                 760                 765             
Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu Asn Cys Glu Trp Val Ile
    770                 775                 780                 
Glu Ala Glu Pro Gly His Ser Ile Lys Ile Thr Phe Glu Arg Phe Gln
785                 790                 795                 800 
Thr Glu Leu Asn Tyr Asp Val Leu Glu Val His Asp Gly Pro Asn Leu
                805                 810                 815     
Leu Ser Pro Leu Leu Gly Ser Tyr Asn Gly Thr Gln Val Pro Gln Phe
            820                 825                 830         
Leu Phe Ser Ser Ser Asn Phe Ile Tyr Leu Leu Phe Thr Thr Asp Asn
        835                 840                 845             
Ser Arg Ser Asn Asn Gly Phe Lys Ile His Tyr Glu Ser Val Thr Val
    850                 855                 860                 
Asn Thr Tyr Ser Cys Leu Asp Pro Gly Ile Pro Val His Gly Arg Arg
865                 870                 875                 880 
Tyr Gly His Asp Phe Ser Ile Gly Ser Thr Val Ser Phe Ser Cys Asp
                885                 890                 895     
Ser Gly Tyr Arg Leu Ser His Glu Glu Pro Leu Leu Cys Glu Lys Asn
            900                 905                 910         
His Trp Trp Ser His Pro Leu Pro Thr Cys Asp Ala Leu Cys Gly Gly
        915                 920                 925             
Asp Val Arg Gly Pro Ser Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu
    930                 935                 940                 
Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Val Asp Val Thr His
945                 950                 955                 960 
Gly Lys Gly Val Gln Phe Asn Phe His Thr Phe His Leu Glu Asp His
                965                 970                 975     
His Asp Tyr Leu Leu Ile Thr Glu Asn Gly Ser Phe Thr Gln Pro Leu
            980                 985                 990         
Ala Arg Leu Thr Gly Ser Asp Leu Pro Pro Thr Ile Asn Ala Gly Leu
        995                 1000                1005            
Tyr Gly Asn Phe Arg Ala Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile
    1010                1015                1020                
Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asn Leu Glu Pro
1025                1030                1035                1040
Cys Glu Asp Pro Gly Ile Pro Gln Tyr Gly Ser Arg Ile Gly Phe Asn
                1045                1050                1055    
Phe Gly Ile Gly Asp Thr Leu Thr Phe Ser Cys Ser Ser Gly Tyr Arg
            1060                1065                1070        
Leu Glu Gly Thr Ser Glu Ile Ile Cys Leu Gly Gly Gly Arg Arg Val
        1075                1080                1085            
Trp Ser Ala Pro Leu Pro Arg Cys Val Ala Glu Cys Gly Ala Ser Ala
    1090                1095                1100                
Thr Asn Asn Glu Gly Ile Leu Leu Ser Pro Asn Tyr Pro Leu Asn Tyr
1105                1110                1115                1120
Glu Asn Asn His Glu Cys Ile Tyr Ser Ile Gln Val Gln Ala Gly Lys
                1125                1130                1135    
Gly Ile Asn Ile Ser Ala Arg Thr Phe His Leu Ala Gln Gly Asp Val
            1140                1145                1150        
Leu Lys Ile Tyr Asp Gly Lys Asp Lys Thr Thr His Leu Leu Gly Ala
        1155                1160                1165            
Phe Thr Gly Ala Ser Met Arg Gly Leu Thr Leu Ser Ser Thr Ser Asn
    1170                1175                1180                
Gln Leu Trp Leu Glu Phe Asn Ser Asp Thr Glu Gly Thr Asp Glu Gly
1185                1190                1195                1200
Phe Gln Leu Val Tyr Thr Ser Phe Glu Leu Ser His Cys Glu Asp Pro
                1205                1210                1215    
Gly Ile Pro Gln Phe Gly Tyr Lys Ile Ser Asp Gln Gly His Phe Ala
            1220                1225                1230        
Gly Ser Thr Ile Ile Tyr Gly Cys Asn Pro Gly Tyr Thr Leu His Gly
        1235                1240                1245            
Ser Ser Leu Leu Lys Cys Met Thr Gly Glu Arg Arg Ala Trp Asp Tyr
    1250                1255                1260                
Pro Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly Arg Phe Lys Gly Glu
1265                1270                1275                1280
Ser Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro Phe Pro Tyr Asp Asn
                1285                1290                1295    
Asn Leu Arg Cys Met Trp Met Ile Glu Val Asp Pro Gly Asn Ile Val
            1300                1305                1310        
Ser Leu Gln Phe Leu Ala Phe Asp Thr Glu Ala Ser His Asp Ile Leu
        1315                1320                1325            
Arg Val Trp Asp Gly Pro Pro Glu Asn Asp Met Leu Leu Lys Glu Ile
    1330                1335                1340                
Ser Gly Ser Leu Ile Pro Glu Gly Ile His Ser Thr Leu Asn Ile Val
1345                1350                1355                1360
Thr Ile Gln Phe Asp Thr Asp Phe Tyr Ile Ser Lys Ser Gly Phe Ala
                1365                1370                1375    
Ile Gln Phe Ser Ser Ser Val Ala Thr Ala Cys Arg Asp Pro Gly Val
            1380                1385                1390        
Pro Met Asn Gly Thr Arg Asn Gly Asp Gly Arg Glu Pro Gly Asp Thr
        1395                1400                1405            
Val Val Phe Gln Cys Asp Pro Gly Tyr Glu Leu Gln Gly Glu Glu Arg
    1410                1415                1420                
Ile Thr Cys Ile Gln Val Glu Asn Arg Tyr Phe Trp Gln Pro Ser Pro
1425                1430                1435                1440
Pro Val Cys Ile Ala Pro Cys Gly Gly Asn Leu Thr Gly Ser Ser Gly
                1445                1450                1455    
Phe Ile Leu Ser Pro Asn Phe Pro His Pro Tyr Pro His Ser Arg Asp
            1460                1465                1470        
Cys Asp Trp Thr Ile Thr Val Asn Ala Asp Tyr Val Ile Ser Leu Ala
        1475                1480                1485            
Phe Ile Ser Phe Ser Ile Glu Pro Asn Tyr Asp Phe Leu Tyr Ile Tyr
    1490                1495                1500                
Asp Gly Pro Asp Ser Asn Ser Pro Leu Ile Gly Ser Phe Gln Asp Ser
1505                1510                1515                1520
Lys Leu Pro Glu Arg Ile Glu Ser Ser Ser Asn Thr Met His Leu Ala
                1525                1530                1535    
Phe Arg Ser Asp Gly Ser Val Ser Tyr Thr Gly Phe His Leu Glu Tyr
            1540                1545                1550        
Lys Ala Lys Leu Arg Glu Ser Cys Phe Asp Pro Gly Asn Ile Met Asn
        1555                1560                1565            
Gly Thr Arg Leu Gly Met Asp Tyr Lys Leu Gly Ser Thr Val Thr Tyr
    1570                1575                1580                
Tyr Cys Asp Ala Gly Tyr Val Leu Gln Gly Tyr Ser Thr Leu Thr Cys
1585                1590                1595                1600
Ile Met Gly Asp Asp Gly Arg Pro Gly Trp Asn Arg Ala Leu Pro Ser
                1605                1610                1615    
Cys His Ala Pro Cys Gly Ser Arg Ser Thr Gly Ser Glu Gly Thr Val
            1620                1625                1630        
Leu Ser Pro Asn Tyr Pro Lys Asn Tyr Ser Val Gly His Asn Cys Val
        1635                1640                1645            
Tyr Ser Ile Ala Val Pro Lys Glu Phe Val Val Phe Gly Gln Phe Val
    1650                1655                1660                
Phe Phe Gln Thr Ser Leu His Asp Val Val Glu Val Tyr Asp Gly Pro
1665                1670                1675                1680
Thr Gln Gln Ser Ser Leu Leu Ser Ser Leu Ser Gly Ser His Ser Gly
                1685                1690                1695    
Glu Ser Leu Pro Leu Ser Ser Gly Asn Gln Ile Thr Ile Arg Phe Thr
            1700                1705                1710        
Ser Val Gly Pro Ile Thr Ala Lys Gly Phe His Phe Val Tyr Gln Ala
        1715                1720                1725            
Val Pro Arg Thr Ser Ser Thr Gln Cys Ser Ser Val Pro Glu Pro Arg
    1730                1735                1740                
Phe Gly Arg Arg Ile Gly Asn Glu Phe Ala Val Gly Ser Ser Val Leu
1745                1750                1755                1760
Phe Asp Cys Asn Pro Gly Tyr Ile Leu His Gly Ser Ile Ala Ile Arg
                1765                1770                1775    
Cys Glu Thr Val Pro Asn Ser Leu Ala Gln Trp Asn Asp Ser Leu Pro
            1780                1785                1790        
Thr Cys Ile Val Pro Cys Gly Gly Ile Leu Thr Lys Arg Lys Gly Thr
        1795                1800                1805            
Ile Leu Ser Pro Gly Tyr Pro Glu Pro Tyr Asp Asn Asn Leu Asn Cys
    1810                1815                1820                
Val Trp Lys Ile Thr Val Pro Glu Gly Ala Gly Ile Gln Val Gln Val
1825                1830                1835                1840
Val Ser Phe Ala Thr Glu His Asn Trp Asp Ser Leu Asp Phe Tyr Asp
                1845                1850                1855    
Gly Gly Asp Asn Asn Ala Pro Arg Leu Gly Ser Tyr Ser Gly Thr Thr
            1860                1865                1870        
Ile Pro His Leu Leu Asn Ser Thr Ser Asn Asn Leu Tyr Leu Asn Phe
        1875                1880                1885            
Gln Ser Asp Ile Ser Val Ser Ala Ala Gly Phe His Leu Glu Tyr Thr
    1890                1895                1900                
Ala Ile Gly Leu Asp Ser Cys Pro Glu Pro Gln Thr Pro Ser Ser Gly
1905                1910                1915                1920
Ile Lys Ile Gly Asp Arg Tyr Met Val Gly Asp Val Val Ser Phe Gln
                1925                1930                1935    
Cys Asp Gln Gly Tyr Ser Leu Gln Gly His Ser His Ile Thr Cys Met
            1940                1945                1950        
Pro Gly Pro Val Arg Arg Trp Asn Tyr Pro Ile Pro Ile Cys Leu Ala
        1955                1960                1965            
Gln Cys Gly Gly Ala Met Ser Asp Phe Ser Gly Val Ile Leu Ser Pro
    1970                1975                1980                
Gly Phe Pro Gly Asn Tyr Pro Ser Ser Leu Asp Cys Thr Trp Thr Ile
1985                1990                1995                2000
Asn Leu Pro Ile Gly Phe Gly Val His Leu Gln Phe Val Asn Phe Ser
                2005                2010                2015    
Thr Glu Thr Ile His Asp Tyr Leu Glu Val Arg Ser Gly Ser Ser Glu
            2020                2025                2030        
Thr Ser Thr Val Ile Gly Arg Leu Ser Gly Pro Gln Ile Pro Ser Ser
        2035                2040                2045            
Leu Phe Ser Thr Thr His Glu Thr Ser Leu Tyr Phe His Ser Asp Tyr
    2050                2055                2060                
Ser Gln Asn Lys Gln Gly Phe His Ile Val Tyr Gln Ala Tyr Gln Leu
2065                2070                2075                2080
Gln Ser Cys Pro Asp Pro Arg Pro Phe Arg Asn Gly Phe Val Ile Gly
                2085                2090                2095    
Asn Asp Phe Thr Val Gly Gln Thr Ile Ser Phe Glu Cys Phe Pro Gly
            2100                2105                2110        
Tyr Thr Leu Ile Gly Asn Ser Ala Leu Thr Cys Leu His Gly Val Ser
        2115                2120                2125            
Arg Asn Trp Asn His Pro Leu Pro Arg Cys Glu Ala Leu Cys Gly Gly
    2130                2135                2140                
Asn Ile Thr Ala Met Asn Gly Thr Ile Tyr Ser Pro Gly Tyr Pro Asp
2145                2150                2155                2160
Glu Tyr Pro Asn Phe Gln Asp Cys Phe Trp Leu Val Arg Val Pro Pro
                2165                2170                2175    
Gly Asn Gly Ile Tyr Ile Asn Phe Thr Val Leu Gln Thr Glu Pro Ile
            2180                2185                2190        
Tyr Asp Phe Ile Thr Val Trp Asp Gly Pro Asp Gln Asn Ser Pro Gln
        2195                2200                2205            
Ile Gly Gln Phe Ser Gly Asn Thr Ala Leu Glu Ser Val Tyr Ser Thr
    2210                2215                2220                
Ser Asn Gln Ile Leu Ile Lys Phe His Ser Asp Phe Thr Thr Ser Gly
2225                2230                2235                2240
Phe Phe Val Leu Ser Tyr His Ala Tyr Gln Leu Arg Val Cys Gln Pro
                2245                2250                2255    
Pro Pro Pro Val Pro Asn Ala Glu Ile Leu Thr Glu Asp Asp Glu Phe
            2260                2265                2270        
Glu Ile Gly Asp Ile Ile Arg Tyr Gln Cys Leu Pro Gly Phe Thr Leu
        2275                2280                2285            
Val Gly Asn Ala Ile Leu Thr Cys Arg Leu Gly Glu Arg Leu Gln Met
    2290                2295                2300                
Asp Gly Ala Pro Pro Val Cys Gln Val Leu Cys Pro Ala Asn Glu Leu
2305                2310                2315                2320
Arg Leu Asp Ser Thr Gly Val Ile Leu Ser Pro Gly Tyr Pro Asp Ser
                2325                2330                2335    
Tyr Pro Asn Leu Gln Met Cys Ala Trp Ser Ile Ser Val Glu Lys Gly
            2340                2345                2350        
Tyr Asn Ile Thr Met Phe Val Glu Phe Phe Gln Thr Glu Lys Glu Phe
        2355                2360                2365            
Asp Val Leu Gln Val Tyr Asp Gly Pro Asn Ile Gln Ser Pro Val Leu
    2370                2375                2380                
Ile Ser Leu Ser Gly Asp Tyr Ser Ser Ala Phe Asn Ile Thr Ser Asn
2385                2390                2395                2400
Gly His Glu Val Phe Leu Gln Trp Ser Ala Asp His Gly Asn Asn Lys
                2405                2410                2415    
Lys Gly Phe Arg Ile Arg Tyr Ile Ala Phe Tyr Cys Ser Thr Pro Glu
            2420                2425                2430        
Ser Pro Pro His Gly Tyr Ile Ile Ser Gln Thr Gly Gly Gln Leu Asn
        2435                2440                2445            
Ser Val Val Arg Trp Ala Cys Asp Arg Gly Phe Arg Leu Val Gly Lys
    2450                2455                2460                
Ser Ser Ala Val Cys Arg Lys Ser Ser Tyr Gly Tyr His Ala Trp Asp
2465                2470                2475                2480
Ala Pro Val Pro Ala Cys Gln Ala Ile Ser Cys Gly Ile Pro Lys Ala
                2485                2490                2495    
Pro Thr Asn Gly Gly Ile Leu Thr Thr Asp Tyr Leu Val Gly Thr Arg
            2500                2505                2510        
Val Thr Tyr Phe Cys Asn Asp Gly Tyr Arg Leu Ser Ser Lys Glu Leu
        2515                2520                2525            
Thr Thr Ala Val Cys Gln Ser Asp Gly Thr Trp Ser Asn His Asn Lys
    2530                2535                2540                
Thr Pro Arg Cys Val Val Ile Ser Cys Gly Glu Leu Pro Thr Pro Pro
2545                2550                2555                2560
Asn Gly Asn Lys Ile Gly Thr Gln Thr Ser Tyr Gly Ser Thr Ala Ile
                2565                2570                2575    
Phe Thr Cys Asp Leu Gly Phe Met Leu Val Gly Ser Ala Val Arg Glu
            2580                2585                2590        
Cys Leu Ser Ser Gly Leu Trp Ser Glu Ser Glu Thr Arg Cys Leu Ala
        2595                2600                2605            
Gly His Cys Gly Ile Pro Glu Leu Ile Val Asn Gly Gln Val Ile Gly
    2610                2615                2620                
Glu Asn Tyr Gly Tyr Arg Asp Thr Val Val Tyr Gln Cys Asn Pro Gly
2625                2630                2635                2640
Phe Arg Leu Ile Gly Ser Ser Val Arg Ile Cys Gln Gln Asp His Asn
                2645                2650                2655    
Trp Ser Gly Gln Leu Pro Ser Cys Val Pro Val Ser Cys Gly His Pro
            2660                2665                2670        
Gly Ser Pro Ile Tyr Gly Arg Thr Ser Gly Asn Gly Phe Asn Phe Asn
        2675                2680                2685            
Asp Val Val Thr Phe Ser Cys Asn Ile Gly Tyr Leu Met Gln Gly Pro
    2690                2695                2700                
Thr Lys Ala Gln Cys Gln Ala Asn Arg Gln Trp Ser His Pro Pro Pro
2705                2710                2715                2720
Met Cys Lys Val Val Asn Cys Ser Asp Pro Gly Ile Pro Ala Asn Ser
                2725                2730                2735    
Lys Arg Glu Ser Lys Ile Glu His Gly Asn Phe Thr Tyr Gly Thr Val
            2740                2745                2750        
Val Phe Tyr Asp Cys Asn Pro Gly Tyr Phe Leu Phe Gly Ser Ser Val
        2755                2760                2765            
Leu Ile Cys Gln Pro Asn Gly Gln Trp Asp Lys Pro Leu Pro Glu Cys
    2770                2775                2780                
Ile Met Ile Asp Cys Gly His Pro Gly Val Pro Pro Asn Ala Val Leu
2785                2790                2795                2800
Ser Gly Glu Lys Tyr Thr Phe Gly Ser Thr Val His Tyr Ser Cys Thr
                2805                2810                2815    
Gly Lys Arg Ser Leu Leu Gly Gln Ser Ser Arg Thr Cys Gln Leu Asn
            2820                2825                2830        
Gly His Trp Ser Gly Ser Gln Pro His Cys Ser Gly Asp Ala Thr Gly
        2835                2840                2845            
Thr Cys Gly Asp Pro Gly Thr Pro Gly His Gly Ser Arg Gln Glu Ser
    2850                2855                2860                
Asn Phe Arg Thr Lys Ser Thr Val Arg Tyr Ala Cys Asp Thr Gly Tyr
2865                2870                2875                2880
Ile Leu His Gly Ser Glu Glu Arg Thr Cys Leu Ala Asn Gly Ser Trp
                2885                2890                2895    
Thr Gly Arg Gln Pro Glu Cys Lys Ala Val Gln Cys Gly Asn Pro Gly
            2900                2905                2910        
Thr Thr Ala Asn Gly Lys Val Phe Arg Ile Asp Gly Thr Thr Phe Ser
        2915                2920                2925            
Ser Ser Val Ile Tyr Ser Cys Met Glu Gly Tyr Ile Leu Ser Gly Pro
    2930                2935                2940                
Ser Val Arg Gln Cys Thr Ala Asn Gly Thr Trp Ser Gly Thr Leu Pro
2945                2950                2955                2960
Asn Cys Thr Ile Ile Ser Cys Gly Asp Pro Gly Ile Pro Ala Asn Gly
                2965                2970                2975    
Leu Arg Tyr Gly Asp Asp Tyr Val Val Gly Gln Asn Val Ser Tyr Met
            2980                2985                2990        
Cys Gln Pro Gly Tyr Thr Met Glu Leu Asn Gly Ser Arg Ile Arg Thr
        2995                3000                3005            
Cys Thr Ile Asn Gly Thr Trp Ser Gly Val Met Pro Thr Cys Arg Ala
    3010                3015                3020                
Val Thr Cys Pro Thr Pro Pro Gln Ile Ser Asn Gly Arg Leu Glu Gly
3025                3030                3035                3040
Thr Asn Phe Asp Trp Gly Phe Ser Ile Ser Tyr Ile Cys Ser Pro Gly
                3045                3050                3055    
Tyr Glu Leu Ser Phe Pro Ala Val Leu Thr Cys Val Gly Asn Gly Thr
            3060                3065                3070        
Trp Ser Gly Glu Val Pro Gln Cys Leu Pro Lys Phe Cys Gly Asp Pro
        3075                3080                3085            
Gly Ile Pro Ala Gln Gly Lys Arg Glu Gly Lys Ser Phe Ile Tyr Gln
    3090                3095                3100                
Ser Glu Val Ser Phe Ser Cys Asn Phe Pro Phe Ile Leu Val Gly Ser
3105                3110                3115                3120
Ser Thr Arg Ile Cys Gln Ala Asp Gly Thr Trp Ser Gly Ser Ser Pro
                3125                3130                3135    
His Cys Ile Glu Pro Thr Gln Thr Ser Cys Glu Asn Pro Gly Val Pro
            3140                3145                3150        
Arg His Gly Ser Gln Asn Asn Thr Phe Gly Phe Gln Val Gly Ser Val
        3155                3160                3165            
Val Gln Phe His Cys Lys Lys Gly His Leu Leu Gln Gly Ser Thr Thr
    3170                3175                3180                
Arg Thr Cys Leu Pro Asp Leu Thr Trp Ser Gly Ile Gln Pro Glu Cys
3185                3190                3195                3200
Ile Pro His Ser Cys Lys Gln Pro Glu Thr Pro Ala His Ala Asn Val
                3205                3210                3215    
Val Gly Met Asp Leu Pro Ser His Gly Tyr Thr Leu Ile Tyr Thr Cys
            3220                3225                3230        
Gln Pro Gly Phe Phe Leu Ala Gly Gly Thr Glu His Arg Val Cys Arg
        3235                3240                3245            
Ser Asp Asn Thr Trp Thr Gly Lys Val Pro Ile Cys Glu Ala Gly Ser
    3250                3255                3260                
Lys Ile Leu Val Lys Asp Pro Arg Pro Ala Leu Gly Thr Pro Ser Pro
3265                3270                3275                3280
Lys Leu Ser Val Pro Asp Asp Val Phe Ala Gln Asn Tyr Ile Trp Lys
                3285                3290                3295    
Gly Ser Tyr Asn Phe Lys Gly Arg Lys Gln Pro Met Thr Leu Thr Val
            3300                3305                3310        
Thr Ser Phe Asn Ala Ser Thr Gly Arg Val Asn Ala Thr Leu Ser Asn
        3315                3320                3325            
Ser Asn Met Glu Leu Leu Leu Ser Gly Val Tyr Lys Ser Gln Glu Ala
    3330                3335                3340                
Arg Leu Met Leu Arg Ile Tyr Leu Ile Lys Val Pro Ala His Ala Ser
3345                3350                3355                3360
Val Lys Lys Met Lys Glu Glu Asn Trp Ala Met Asp Gly Phe Val Ser
                3365                3370                3375    
Ala Glu Pro Asp Gly Ala Thr Tyr Val Phe Gln Gly Phe Ile Gln Gly
            3380                3385                3390        
Lys Asp Tyr Gly Gln Phe Gly Leu Gln Arg Leu Gly Leu Asn Met Ser
        3395                3400                3405            
Glu Gly Ser Asn Ser Ser Asn Gln Pro His Gly Thr Asn Ser Ser Ser
    3410                3415                3420                
Val Ala Ile Ala Ile Leu Val Pro Phe Phe Ala Leu Ile Phe Ala Gly
3425                3430                3435                3440
Phe Gly Phe Tyr Leu Tyr Lys Gln Arg Thr Ala Pro Lys Thr Gln Tyr
                3445                3450                3455    
Thr Gly Cys Ser Val His Glu Asn Asn Asn Gly Gln Ala Ala Phe Glu
            3460                3465                3470        
Asn Pro Met Tyr Asp Thr Asn Ala Lys Ser Val Glu Gly Lys Ala Val
        3475                3480                3485            
Arg Phe Asp Pro Asn Leu Asn Thr Val Cys Thr Met Val
    3490                3495                3500    


<210> 9279
<211> 3707
<212> PRT
<213> Homo sapiens

<400> 9279
Met Lys Gly Ile Arg Lys Gly Glu Ser Arg Ala Lys Glu Ser Lys Pro
 1               5                  10                  15      
Trp Glu Pro Gly Lys Arg Arg Cys Ala Lys Cys Gly Arg Leu Asp Phe
            20                  25                  30          
Ile Leu Met Lys Lys Met Gly Ile Lys Ser Gly Phe Thr Phe Trp Asn
        35                  40                  45              
Leu Val Phe Leu Leu Thr Val Ser Cys Val Lys Gly Phe Ile Tyr Thr
    50                  55                  60                  
Cys Gly Gly Thr Leu Lys Gly Leu Asn Gly Thr Ile Glu Ser Pro Gly
65                  70                  75                  80  
Phe Pro Tyr Gly Tyr Pro Asn Gly Ala Asn Cys Thr Trp Val Ile Ile
                85                  90                  95      
Ala Glu Glu Arg Asn Arg Ile Gln Ile Val Phe Gln Ser Phe Ala Leu
            100                 105                 110         
Glu Glu Glu Tyr Asp Tyr Leu Ser Leu Tyr Asp Gly His Pro His Pro
        115                 120                 125             
Thr Asn Phe Arg Thr Arg Leu Thr Gly Phe His Leu Pro Pro Pro Val
    130                 135                 140                 
Thr Ser Thr Lys Ser Val Phe Ser Leu Arg Leu Thr Ser Asp Phe Ala
145                 150                 155                 160 
Val Ser Ala His Gly Phe Lys Val Tyr Tyr Glu Glu Leu Gln Ser Ser
                165                 170                 175     
Ser Cys Gly Asn Pro Gly Val Pro Pro Lys Gly Val Leu Tyr Gly Thr
            180                 185                 190         
Arg Phe Asp Val Gly Asp Lys Ile Arg Tyr Ser Cys Val Thr Gly Tyr
        195                 200                 205             
Ile Leu Asp Gly His Pro Gln Leu Thr Cys Ile Ala Asn Ser Val Asn
    210                 215                 220                 
Thr Ala Ser Trp Asp Phe Pro Val Pro Ile Cys Arg Ala Glu Asp Ala
225                 230                 235                 240 
Cys Gly Gly Thr Met Arg Gly Ser Ser Gly Ile Ile Ser Ser Pro Ser
                245                 250                 255     
Phe Pro Asn Glu Tyr His Asn Asn Ala Asp Cys Thr Trp Thr Ile Val
            260                 265                 270         
Ala Glu Pro Gly Asp Thr Ile Ser Leu Ile Phe Thr Asp Phe Gln Met
        275                 280                 285             
Glu Glu Lys Tyr Asp Tyr Leu Glu Ile Glu Gly Ser Glu Pro Pro Thr
    290                 295                 300                 
Ile Trp Leu Ser Gly Met Asn Ile Pro Pro Pro Ile Ile Ser Asn Lys
305                 310                 315                 320 
Asn Trp Leu Arg Leu His Phe Val Thr Asp Ser Asn His Arg Tyr Arg
                325                 330                 335     
Gly Phe Ser Ala Pro Tyr Gln Gly Ser Ser Thr Leu Thr His Thr Thr
            340                 345                 350         
Ser Thr Gly Glu Leu Glu Glu His Asn Arg Thr Thr Thr Gly Ala Ile
        355                 360                 365             
Ala Val Ala Ser Thr Pro Ala Asp Val Thr Val Ser Ser Val Thr Ala
    370                 375                 380                 
Val Thr Ile His Arg Leu Ser Glu Glu Gln Arg Val Gln Val Thr Ser
385                 390                 395                 400 
Leu Arg Asn Ser Gly Leu Asp Pro Asn Thr Ser Lys Asp Gly Leu Ser
                405                 410                 415     
Pro His Pro Ala Asp Thr Gln Ser Thr Arg Arg Arg Pro Arg His Ala
            420                 425                 430         
Glu Gln Ile Glu Arg Thr Lys Glu Leu Ala Val Val Thr His Arg Val
        435                 440                 445             
Lys Lys Ala Ile Asp Phe Lys Ser Arg Gly Phe Lys Leu Phe Pro Gly
    450                 455                 460                 
Lys Asp Asn Ser Asn Lys Phe Ser Ile Leu Asn Glu Gly Gly Ile Lys
465                 470                 475                 480 
Thr Ala Ser Asn Leu Cys Pro Asp Pro Gly Glu Pro Glu Asn Gly Lys
                485                 490                 495     
Arg Ile Gly Ser Asp Phe Ser Leu Gly Ser Thr Val Gln Phe Ser Cys
            500                 505                 510         
Asp Glu Asp Tyr Val Leu Gln Gly Ala Lys Ser Ile Thr Cys Gln Arg
        515                 520                 525             
Ile Ala Glu Val Phe Ala Ala Trp Ser Asp His Arg Pro Val Cys Lys
    530                 535                 540                 
Val Lys Thr Cys Gly Ser Asn Leu Gln Gly Pro Ser Gly Thr Phe Thr
545                 550                 555                 560 
Ser Pro Asn Phe Pro Phe Gln Tyr Asp Ser Asn Ala Gln Cys Val Trp
                565                 570                 575     
Val Ile Thr Ala Val Asn Thr Asn Lys Val Ile Gln Ile Asn Phe Glu
            580                 585                 590         
Glu Phe Asp Leu Glu Ile Gly Tyr Asp Thr Leu Thr Ile Gly Asp Gly
        595                 600                 605             
Gly Glu Val Gly Asp Pro Arg Thr Val Leu Gln Val Leu Thr Gly Ser
    610                 615                 620                 
Phe Val Pro Asp Leu Ile Val Ser Met Ser Ser Gln Met Trp Leu His
625                 630                 635                 640 
Leu Gln Thr Asp Glu Ser Val Gly Ser Val Gly Phe Lys Val Asn Tyr
                645                 650                 655     
Lys Glu Ile Glu Lys Glu Ser Cys Gly Asp Pro Gly Thr Pro Leu Tyr
            660                 665                 670         
Gly Ile Arg Glu Gly Asp Gly Phe Ser Asn Arg Asp Val Leu Arg Phe
        675                 680                 685             
Glu Cys Gln Phe Gly Phe Glu Leu Ile Gly Glu Lys Ser Ile Val Cys
    690                 695                 700                 
Gln Glu Asn Asn Gln Trp Ser Ala Asn Ile Pro Ile Cys Ile Phe Pro
705                 710                 715                 720 
Cys Leu Ser Asn Phe Thr Ala Pro Met Gly Thr Val Leu Ser Pro Asp
                725                 730                 735     
Tyr Pro Glu Gly Tyr Gly Asn Asn Leu Asn Cys Ile Trp Thr Ile Ile
            740                 745                 750         
Ser Asp Pro Gly Ser Arg Ile His Leu Ser Phe Asn Asp Phe Asp Leu
        755                 760                 765             
Glu Ser Gln Phe Asp Phe Leu Ala Val Lys Asp Gly Asp Ser Pro Glu
    770                 775                 780                 
Ser Pro Ile Leu Gly Thr Phe Thr Gly Ala Glu Val Pro Ser His Leu
785                 790                 795                 800 
Thr Ser Asn Ser His Ile Leu Arg Leu Glu Phe Gln Ala Asp His Ser
                805                 810                 815     
Met Ser Gly Arg Gly Phe Asn Ile Thr Tyr Asn Thr Phe Gly His Asn
            820                 825                 830         
Glu Cys Pro Asp Pro Gly Ile Pro Ile Asn Ala Arg Arg Phe Gly Asp
        835                 840                 845             
Asn Phe Gln Leu Gly Ser Ser Ile Ser Val Ile Cys Glu Glu Gly Phe
    850                 855                 860                 
Ile Lys Thr Gln Gly Thr Glu Thr Ile Thr Cys Ile Leu Met Asp Gly
865                 870                 875                 880 
Lys Val Met Trp Ser Gly Leu Ile Pro Lys Cys Gly Ala Pro Cys Gly
                885                 890                 895     
Gly His Phe Ser Ala Pro Ser Gly Val Ile Leu Ser Pro Gly Trp Pro
            900                 905                 910         
Gly Tyr Tyr Lys Asp Ser Leu Asn Cys Glu Trp Val Ile Glu Ala Glu
        915                 920                 925             
Pro Gly His Ser Ile Lys Ile Thr Phe Glu Arg Phe Gln Thr Glu Leu
    930                 935                 940                 
Asn Tyr Asp Val Leu Glu Val His Asp Gly Pro Asn Leu Leu Ser Pro
945                 950                 955                 960 
Leu Leu Gly Ser Tyr Asn Gly Thr Gln Val Pro Gln Phe Leu Phe Ser
                965                 970                 975     
Ser Ser Asn Phe Ile Tyr Leu Leu Phe Thr Thr Asp Asn Ser Arg Ser
            980                 985                 990         
Asn Asn Gly Phe Lys Ile His Tyr Glu Ser Val Thr Val Asn Thr Tyr
        995                 1000                1005            
Ser Cys Leu Asp Pro Gly Ile Pro Val His Gly Arg Arg Tyr Gly His
    1010                1015                1020                
Asp Phe Ser Ile Gly Ser Thr Val Ser Phe Ser Cys Asp Ser Gly Tyr
1025                1030                1035                1040
Arg Leu Ser His Glu Glu Pro Leu Leu Cys Glu Lys Asn His Trp Trp
                1045                1050                1055    
Ser His Pro Leu Pro Thr Cys Asp Ala Leu Cys Gly Gly Asp Val Arg
            1060                1065                1070        
Gly Pro Ser Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu Phe Tyr Pro
        1075                1080                1085            
Asn Ser Leu Asn Cys Thr Trp Thr Val Asp Val Thr His Gly Lys Gly
    1090                1095                1100                
Val Gln Phe Asn Phe His Thr Phe His Leu Glu Asp His His Asp Tyr
1105                1110                1115                1120
Leu Leu Ile Thr Glu Asn Gly Ser Phe Thr Gln Pro Leu Ala Arg Leu
                1125                1130                1135    
Thr Gly Ser Asp Leu Pro Pro Thr Ile Asn Ala Gly Leu Tyr Gly Asn
            1140                1145                1150        
Phe Arg Ala Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile Ser Tyr Glu
        1155                1160                1165            
Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asn Leu Glu Pro Cys Glu Asp
    1170                1175                1180                
Pro Gly Ile Pro Gln Tyr Gly Ser Arg Ile Gly Phe Asn Phe Gly Ile
1185                1190                1195                1200
Gly Asp Thr Leu Thr Phe Ser Cys Ser Ser Gly Tyr Arg Leu Glu Gly
                1205                1210                1215    
Thr Ser Glu Ile Ile Cys Leu Gly Gly Gly Arg Arg Val Trp Ser Ala
            1220                1225                1230        
Pro Leu Pro Arg Cys Val Ala Glu Cys Gly Ala Ser Ala Thr Asn Asn
        1235                1240                1245            
Glu Gly Ile Leu Leu Ser Pro Asn Tyr Pro Leu Asn Tyr Glu Asn Asn
    1250                1255                1260                
His Glu Cys Ile Tyr Ser Ile Gln Val Gln Ala Gly Lys Gly Ile Asn
1265                1270                1275                1280
Ile Ser Ala Arg Thr Phe His Leu Ala Gln Gly Asp Val Leu Lys Ile
                1285                1290                1295    
Tyr Asp Gly Lys Asp Lys Thr Thr His Leu Leu Gly Ala Phe Thr Gly
            1300                1305                1310        
Ala Ser Met Arg Gly Leu Thr Leu Ser Ser Thr Ser Asn Gln Leu Trp
        1315                1320                1325            
Leu Glu Phe Asn Ser Asp Thr Glu Gly Thr Asp Glu Gly Phe Gln Leu
    1330                1335                1340                
Val Tyr Thr Ser Phe Glu Leu Ser His Cys Glu Asp Pro Gly Ile Pro
1345                1350                1355                1360
Gln Phe Gly Tyr Lys Ile Ser Asp Gln Gly His Phe Ala Gly Ser Thr
                1365                1370                1375    
Ile Ile Tyr Gly Cys Asn Pro Gly Tyr Thr Leu His Gly Ser Ser Leu
            1380                1385                1390        
Leu Lys Cys Met Thr Gly Glu Arg Arg Ala Trp Asp Tyr Pro Leu Pro
        1395                1400                1405            
Ser Cys Ile Ala Glu Cys Gly Gly Arg Phe Lys Gly Glu Ser Ser Gly
    1410                1415                1420                
Arg Ile Leu Ser Pro Gly Tyr Pro Phe Pro Tyr Asp Asn Asn Leu Arg
1425                1430                1435                1440
Cys Met Trp Met Ile Glu Val Asp Pro Gly Asn Ile Val Ser Leu Gln
                1445                1450                1455    
Phe Leu Ala Phe Asp Thr Glu Ala Ser His Asp Ile Leu Arg Val Trp
            1460                1465                1470        
Asp Gly Pro Pro Glu Asn Asp Met Leu Leu Lys Glu Ile Ser Gly Ser
        1475                1480                1485            
Leu Ile Pro Glu Gly Ile His Ser Thr Leu Asn Ile Val Thr Ile Gln
    1490                1495                1500                
Phe Asp Thr Asp Phe Tyr Ile Ser Lys Ser Gly Phe Ala Ile Gln Phe
1505                1510                1515                1520
Ser Ser Ser Val Ala Thr Ala Cys Arg Asp Pro Gly Val Pro Met Asn
                1525                1530                1535    
Gly Thr Arg Asn Gly Asp Gly Arg Glu Pro Gly Asp Thr Val Val Phe
            1540                1545                1550        
Gln Cys Asp Pro Gly Tyr Glu Leu Gln Gly Glu Glu Arg Ile Thr Cys
        1555                1560                1565            
Ile Gln Val Glu Asn Arg Tyr Phe Trp Gln Pro Ser Pro Pro Val Cys
    1570                1575                1580                
Ile Ala Pro Cys Gly Gly Asn Leu Thr Gly Ser Ser Gly Phe Ile Leu
1585                1590                1595                1600
Ser Pro Asn Phe Pro His Pro Tyr Pro His Ser Arg Asp Cys Asp Trp
                1605                1610                1615    
Thr Ile Thr Val Asn Ala Asp Tyr Val Ile Ser Leu Ala Phe Ile Ser
            1620                1625                1630        
Phe Ser Ile Glu Pro Asn Tyr Asp Phe Leu Tyr Ile Tyr Asp Gly Pro
        1635                1640                1645            
Asp Ser Asn Ser Pro Leu Ile Gly Ser Phe Gln Asp Ser Lys Leu Pro
    1650                1655                1660                
Glu Arg Ile Glu Ser Ser Ser Asn Thr Met His Leu Ala Phe Arg Ser
1665                1670                1675                1680
Asp Gly Ser Val Ser Tyr Thr Gly Phe His Leu Glu Tyr Lys Ala Lys
                1685                1690                1695    
Leu Arg Glu Ser Cys Phe Asp Pro Gly Asn Ile Met Asn Gly Thr Arg
            1700                1705                1710        
Leu Gly Met Asp Tyr Lys Leu Gly Ser Thr Val Thr Tyr Tyr Cys Asp
        1715                1720                1725            
Ala Gly Tyr Val Leu Gln Gly Tyr Ser Thr Leu Thr Cys Ile Met Gly
    1730                1735                1740                
Asp Asp Gly Arg Pro Gly Trp Asn Arg Ala Leu Pro Ser Cys His Ala
1745                1750                1755                1760
Pro Cys Gly Ser Arg Ser Thr Gly Ser Glu Gly Thr Val Leu Ser Pro
                1765                1770                1775    
Asn Tyr Pro Lys Asn Tyr Ser Val Gly His Asn Cys Val Tyr Ser Ile
            1780                1785                1790        
Ala Val Pro Lys Glu Phe Val Val Phe Gly Gln Phe Val Phe Phe Gln
        1795                1800                1805            
Thr Ser Leu His Asp Val Val Glu Val Tyr Asp Gly Pro Thr Gln Gln
    1810                1815                1820                
Ser Ser Leu Leu Ser Ser Leu Ser Gly Ser His Ser Gly Glu Ser Leu
1825                1830                1835                1840
Pro Leu Ser Ser Gly Asn Gln Ile Thr Ile Arg Phe Thr Ser Val Gly
                1845                1850                1855    
Pro Ile Thr Ala Lys Gly Phe His Phe Val Tyr Gln Ala Val Pro Arg
            1860                1865                1870        
Thr Ser Ser Thr Gln Cys Ser Ser Val Pro Glu Pro Arg Phe Gly Arg
        1875                1880                1885            
Arg Ile Gly Asn Glu Phe Ala Val Gly Ser Ser Val Leu Phe Asp Cys
    1890                1895                1900                
Asn Pro Gly Tyr Ile Leu His Gly Ser Ile Ala Ile Arg Cys Glu Thr
1905                1910                1915                1920
Val Pro Asn Ser Leu Ala Gln Trp Asn Asp Ser Leu Pro Thr Cys Ile
                1925                1930                1935    
Val Pro Cys Gly Gly Ile Leu Thr Lys Arg Lys Gly Thr Ile Leu Ser
            1940                1945                1950        
Pro Gly Tyr Pro Glu Pro Tyr Asp Asn Asn Leu Asn Cys Val Trp Lys
        1955                1960                1965            
Ile Thr Val Pro Glu Gly Ala Gly Ile Gln Val Gln Val Val Ser Phe
    1970                1975                1980                
Ala Thr Glu His Asn Trp Asp Ser Leu Asp Phe Tyr Asp Gly Gly Asp
1985                1990                1995                2000
Asn Asn Ala Pro Arg Leu Gly Ser Tyr Ser Gly Thr Thr Ile Pro His
                2005                2010                2015    
Leu Leu Asn Ser Thr Ser Asn Asn Leu Tyr Leu Asn Phe Gln Ser Asp
            2020                2025                2030        
Ile Ser Val Ser Ala Ala Gly Phe His Leu Glu Tyr Thr Ala Ile Gly
        2035                2040                2045            
Leu Asp Ser Cys Pro Glu Pro Gln Thr Pro Ser Ser Gly Ile Lys Ile
    2050                2055                2060                
Gly Asp Arg Tyr Met Val Gly Asp Val Val Ser Phe Gln Cys Asp Gln
2065                2070                2075                2080
Gly Tyr Ser Leu Gln Gly His Ser His Ile Thr Cys Met Pro Gly Pro
                2085                2090                2095    
Val Arg Arg Trp Asn Tyr Pro Ile Pro Ile Cys Leu Ala Gln Cys Gly
            2100                2105                2110        
Gly Ala Met Ser Asp Phe Ser Gly Val Ile Leu Ser Pro Gly Phe Pro
        2115                2120                2125            
Gly Asn Tyr Pro Ser Ser Leu Asp Cys Thr Trp Thr Ile Asn Leu Pro
    2130                2135                2140                
Ile Gly Phe Gly Val His Leu Gln Phe Val Asn Phe Ser Thr Glu Thr
2145                2150                2155                2160
Ile His Asp Tyr Leu Glu Val Arg Ser Gly Ser Ser Glu Thr Ser Thr
                2165                2170                2175    
Val Ile Gly Arg Leu Ser Gly Pro Gln Ile Pro Ser Ser Leu Phe Ser
            2180                2185                2190        
Thr Thr His Glu Thr Ser Leu Tyr Phe His Ser Asp Tyr Ser Gln Asn
        2195                2200                2205            
Lys Gln Gly Phe His Ile Val Tyr Gln Ala Tyr Gln Leu Gln Ser Cys
    2210                2215                2220                
Pro Asp Pro Arg Pro Phe Arg Asn Gly Phe Val Ile Gly Asn Asp Phe
2225                2230                2235                2240
Thr Val Gly Gln Thr Ile Ser Phe Glu Cys Phe Pro Gly Tyr Thr Leu
                2245                2250                2255    
Ile Gly Asn Ser Ala Leu Thr Cys Leu His Gly Val Ser Arg Asn Trp
            2260                2265                2270        
Asn His Pro Leu Pro Arg Cys Glu Ala Leu Cys Gly Gly Asn Ile Thr
        2275                2280                2285            
Ala Met Asn Gly Thr Ile Tyr Ser Pro Gly Tyr Pro Asp Glu Tyr Pro
    2290                2295                2300                
Asn Phe Gln Asp Cys Phe Trp Leu Val Arg Val Pro Pro Gly Asn Gly
2305                2310                2315                2320
Ile Tyr Ile Asn Phe Thr Val Leu Gln Thr Glu Pro Ile Tyr Asp Phe
                2325                2330                2335    
Ile Thr Val Trp Asp Gly Pro Asp Gln Asn Ser Pro Gln Ile Gly Gln
            2340                2345                2350        
Phe Ser Gly Asn Thr Ala Leu Glu Ser Val Tyr Ser Thr Ser Asn Gln
        2355                2360                2365            
Ile Leu Ile Lys Phe His Ser Asp Phe Thr Thr Ser Gly Phe Phe Val
    2370                2375                2380                
Leu Ser Tyr His Ala Tyr Gln Leu Arg Val Cys Gln Pro Pro Pro Pro
2385                2390                2395                2400
Val Pro Asn Ala Glu Ile Leu Thr Glu Asp Asp Glu Phe Glu Ile Gly
                2405                2410                2415    
Asp Ile Ile Arg Tyr Gln Cys Leu Pro Gly Phe Thr Leu Val Gly Asn
            2420                2425                2430        
Ala Ile Leu Thr Cys Arg Leu Gly Glu Arg Leu Gln Met Asp Gly Ala
        2435                2440                2445            
Pro Pro Val Cys Gln Val Leu Cys Pro Ala Asn Glu Leu Arg Leu Asp
    2450                2455                2460                
Ser Thr Gly Val Ile Leu Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Asn
2465                2470                2475                2480
Leu Gln Met Cys Ala Trp Ser Ile Ser Val Glu Lys Gly Tyr Asn Ile
                2485                2490                2495    
Thr Met Phe Val Glu Phe Phe Gln Thr Glu Lys Glu Phe Asp Val Leu
            2500                2505                2510        
Gln Val Tyr Asp Gly Pro Asn Ile Gln Ser Pro Val Leu Ile Ser Leu
        2515                2520                2525            
Ser Gly Asp Tyr Ser Ser Ala Phe Asn Ile Thr Ser Asn Gly His Glu
    2530                2535                2540                
Val Phe Leu Gln Trp Ser Ala Asp His Gly Asn Asn Lys Lys Gly Phe
2545                2550                2555                2560
Arg Ile Arg Tyr Ile Ala Phe Tyr Cys Ser Thr Pro Glu Ser Pro Pro
                2565                2570                2575    
His Gly Tyr Ile Ile Ser Gln Thr Gly Gly Gln Leu Asn Ser Val Val
            2580                2585                2590        
Arg Trp Ala Cys Asp Arg Gly Phe Arg Leu Val Gly Lys Ser Ser Ala
        2595                2600                2605            
Val Cys Arg Lys Ser Ser Tyr Gly Tyr His Ala Trp Asp Ala Pro Val
    2610                2615                2620                
Pro Ala Cys Gln Ala Ile Ser Cys Gly Ile Pro Lys Ala Pro Thr Asn
2625                2630                2635                2640
Gly Gly Ile Leu Thr Thr Asp Tyr Leu Val Gly Thr Arg Val Thr Tyr
                2645                2650                2655    
Phe Cys Asn Asp Gly Tyr Arg Leu Ser Ser Lys Glu Leu Thr Thr Ala
            2660                2665                2670        
Val Cys Gln Ser Asp Gly Thr Trp Ser Asn His Asn Lys Thr Pro Arg
        2675                2680                2685            
Cys Val Val Val Thr Cys Pro Ser Ile Asn Ser Phe Ile Leu Glu His
    2690                2695                2700                
Gly Arg Trp Arg Ile Val Asn Gly Ser His Tyr Glu Tyr Lys Thr Lys
2705                2710                2715                2720
Val Val Phe Ser Cys Asp Pro Gly Tyr His Gly Leu Gly Pro Ala Ser
                2725                2730                2735    
Ile Glu Cys Leu Pro Asn Gly Thr Trp Ser Trp Arg Asn Glu Arg Pro
            2740                2745                2750        
Tyr Cys Gln Ile Ile Ser Cys Gly Glu Leu Pro Thr Pro Pro Asn Gly
        2755                2760                2765            
Asn Lys Ile Gly Thr Gln Thr Ser Tyr Gly Ser Thr Ala Ile Phe Thr
    2770                2775                2780                
Cys Asp Leu Gly Phe Met Leu Val Gly Ser Ala Val Arg Glu Cys Leu
2785                2790                2795                2800
Ser Ser Gly Leu Trp Ser Glu Ser Glu Thr Arg Cys Leu Ala Gly His
                2805                2810                2815    
Cys Gly Ile Pro Glu Leu Ile Val Asn Gly Gln Val Ile Gly Glu Asn
            2820                2825                2830        
Tyr Gly Tyr Arg Asp Thr Val Val Tyr Gln Cys Asn Pro Gly Phe Arg
        2835                2840                2845            
Leu Ile Gly Ser Ser Val Arg Ile Cys Gln Gln Asp His Asn Trp Ser
    2850                2855                2860                
Gly Gln Leu Pro Ser Cys Val Pro Val Ser Cys Gly His Pro Gly Ser
2865                2870                2875                2880
Pro Ile Tyr Gly Arg Thr Ser Gly Asn Gly Phe Asn Phe Asn Asp Val
                2885                2890                2895    
Val Thr Phe Ser Cys Asn Ile Gly Tyr Leu Met Gln Gly Pro Thr Lys
            2900                2905                2910        
Ala Gln Cys Gln Ala Asn Arg Gln Trp Ser His Pro Pro Pro Met Cys
        2915                2920                2925            
Lys Val Val Asn Cys Ser Asp Pro Gly Ile Pro Ala Asn Ser Lys Arg
    2930                2935                2940                
Glu Ser Lys Ile Glu His Gly Asn Phe Thr Tyr Gly Thr Val Val Phe
2945                2950                2955                2960
Tyr Asp Cys Asn Pro Gly Tyr Phe Leu Phe Gly Ser Ser Val Leu Ile
                2965                2970                2975    
Cys Gln Pro Asn Gly Gln Trp Asp Lys Pro Leu Pro Glu Cys Ile Met
            2980                2985                2990        
Ile Asp Cys Gly His Pro Gly Val Pro Pro Asn Ala Val Leu Ser Gly
        2995                3000                3005            
Glu Lys Tyr Thr Phe Gly Ser Thr Val His Tyr Ser Cys Thr Gly Lys
    3010                3015                3020                
Arg Ser Leu Leu Gly Gln Ser Ser Arg Thr Cys Gln Leu Asn Gly His
3025                3030                3035                3040
Trp Ser Gly Ser Gln Pro His Cys Ser Gly Asp Ala Thr Gly Thr Cys
                3045                3050                3055    
Gly Asp Pro Gly Thr Pro Gly His Gly Ser Arg Gln Glu Ser Asn Phe
            3060                3065                3070        
Arg Thr Lys Ser Thr Val Arg Tyr Ala Cys Asp Thr Gly Tyr Ile Leu
        3075                3080                3085            
His Gly Ser Glu Glu Arg Thr Cys Leu Ala Asn Gly Ser Trp Thr Gly
    3090                3095                3100                
Arg Gln Pro Glu Cys Lys Ala Val Gln Cys Gly Asn Pro Gly Thr Thr
3105                3110                3115                3120
Ala Asn Gly Lys Val Phe Arg Ile Asp Gly Thr Thr Phe Ser Ser Ser
                3125                3130                3135    
Val Ile Tyr Ser Cys Met Glu Gly Tyr Ile Leu Ser Gly Pro Ser Val
            3140                3145                3150        
Arg Gln Cys Thr Ala Asn Gly Thr Trp Ser Gly Thr Leu Pro Asn Cys
        3155                3160                3165            
Thr Ile Ile Ser Cys Gly Asp Pro Gly Ile Pro Ala Asn Gly Leu Arg
    3170                3175                3180                
Tyr Gly Asp Asp Tyr Val Val Gly Gln Asn Val Ser Tyr Met Cys Gln
3185                3190                3195                3200
Pro Gly Tyr Thr Met Glu Leu Asn Gly Ser Arg Ile Arg Thr Cys Thr
                3205                3210                3215    
Ile Asn Gly Thr Trp Ser Gly Val Met Pro Thr Cys Arg Ala Val Thr
            3220                3225                3230        
Cys Pro Thr Pro Pro Gln Ile Ser Asn Gly Arg Leu Glu Gly Thr Asn
        3235                3240                3245            
Phe Asp Trp Gly Phe Ser Ile Ser Tyr Ile Cys Ser Pro Gly Tyr Glu
    3250                3255                3260                
Leu Ser Phe Pro Ala Val Leu Thr Cys Val Gly Asn Gly Thr Trp Ser
3265                3270                3275                3280
Gly Glu Val Pro Gln Cys Leu Pro Lys Phe Cys Gly Asp Pro Gly Ile
                3285                3290                3295    
Pro Ala Gln Gly Lys Arg Glu Gly Lys Ser Phe Ile Tyr Gln Ser Glu
            3300                3305                3310        
Val Ser Phe Ser Cys Asn Phe Pro Phe Ile Leu Val Gly Ser Ser Thr
        3315                3320                3325            
Arg Ile Cys Gln Ala Asp Gly Thr Trp Ser Gly Ser Ser Pro His Cys
    3330                3335                3340                
Ile Glu Pro Thr Gln Thr Ser Cys Glu Asn Pro Gly Val Pro Arg His
3345                3350                3355                3360
Gly Ser Gln Asn Asn Thr Phe Gly Phe Gln Val Gly Ser Val Val Gln
                3365                3370                3375    
Phe His Cys Lys Lys Gly His Leu Leu Gln Gly Ser Thr Thr Arg Thr
            3380                3385                3390        
Cys Leu Pro Asp Leu Thr Trp Ser Gly Ile Gln Pro Glu Cys Ile Pro
        3395                3400                3405            
His Ser Cys Lys Gln Pro Glu Thr Pro Ala His Ala Asn Val Val Gly
    3410                3415                3420                
Met Asp Leu Pro Ser His Gly Tyr Thr Leu Ile Tyr Thr Cys Gln Pro
3425                3430                3435                3440
Gly Phe Phe Leu Ala Gly Gly Thr Glu His Arg Val Cys Arg Ser Asp
                3445                3450                3455    
Asn Thr Trp Thr Gly Lys Val Pro Ile Cys Glu Ala Gly Ser Lys Ile
            3460                3465                3470        
Leu Val Lys Asp Pro Arg Pro Ala Leu Gly Thr Pro Ser Pro Lys Leu
        3475                3480                3485            
Ser Val Pro Asp Asp Val Phe Ala Gln Asn Tyr Ile Trp Lys Gly Ser
    3490                3495                3500                
Tyr Asn Phe Lys Gly Arg Lys Gln Pro Met Thr Leu Thr Val Thr Ser
3505                3510                3515                3520
Phe Asn Ala Ser Thr Gly Arg Val Asn Ala Thr Leu Ser Asn Ser Asn
                3525                3530                3535    
Met Glu Leu Leu Leu Ser Gly Val Tyr Lys Ser Gln Glu Ala Arg Leu
            3540                3545                3550        
Met Leu Arg Ile Tyr Leu Ile Lys Val Pro Ala His Ala Ser Val Lys
        3555                3560                3565            
Lys Met Lys Glu Glu Asn Trp Ala Met Asp Gly Phe Val Ser Ala Glu
    3570                3575                3580                
Pro Asp Gly Ala Thr Tyr Val Phe Gln Gly Phe Ile Gln Gly Lys Asp
3585                3590                3595                3600
Tyr Gly Gln Phe Gly Leu Gln Arg Leu Gly Leu Asn Met Ser Glu Gly
                3605                3610                3615    
Ser Asn Ser Ser Asn Gln Pro His Gly Thr Asn Ser Ser Ser Val Ala
            3620                3625                3630        
Ile Ala Ile Leu Val Pro Phe Phe Ala Leu Ile Phe Ala Gly Phe Gly
        3635                3640                3645            
Phe Tyr Leu Tyr Lys Gln Arg Thr Ala Pro Lys Thr Gln Tyr Thr Gly
    3650                3655                3660                
Cys Ser Val His Glu Asn Asn Asn Gly Gln Ala Ala Phe Glu Asn Pro
3665                3670                3675                3680
Met Tyr Asp Thr Asn Ala Lys Ser Val Glu Gly Lys Ala Val Arg Phe
                3685                3690                3695    
Asp Pro Asn Leu Asn Thr Val Cys Thr Met Val
            3700                3705        


<210> 9280
<211> 3667
<212> PRT
<213> Homo sapiens

<400> 9280
Met Trp Ser Trp Phe Leu Cys Trp Lys Pro Val Gln Leu Asp Arg Gln
 1               5                  10                  15      
Thr Ala Ser Gly Phe Ile Tyr Thr Cys Gly Gly Thr Leu Lys Gly Leu
            20                  25                  30          
Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro Tyr Gly Tyr Pro Asn Gly
        35                  40                  45              
Ala Asn Cys Thr Trp Val Ile Ile Ala Glu Glu Arg Asn Arg Ile Gln
    50                  55                  60                  
Ile Val Phe Gln Ser Phe Ala Leu Glu Glu Glu Tyr Asp Tyr Leu Ser
65                  70                  75                  80  
Leu Tyr Asp Gly His Pro His Pro Thr Asn Phe Arg Thr Arg Leu Thr
                85                  90                  95      
Gly Phe His Leu Pro Pro Pro Val Thr Ser Thr Lys Ser Val Phe Ser
            100                 105                 110         
Leu Arg Leu Thr Ser Asp Phe Ala Val Ser Ala His Gly Phe Lys Val
        115                 120                 125             
Tyr Tyr Glu Glu Leu Gln Ser Ser Ser Cys Gly Asn Pro Gly Val Pro
    130                 135                 140                 
Pro Lys Gly Val Leu Tyr Gly Thr Arg Phe Asp Val Gly Asp Lys Ile
145                 150                 155                 160 
Arg Tyr Ser Cys Val Thr Gly Tyr Ile Leu Asp Gly His Pro Gln Leu
                165                 170                 175     
Thr Cys Ile Ala Asn Ser Val Asn Thr Ala Ser Trp Asp Phe Pro Val
            180                 185                 190         
Pro Ile Cys Arg Ala Glu Asp Ala Cys Gly Gly Thr Met Arg Gly Ser
        195                 200                 205             
Ser Gly Ile Ile Ser Ser Pro Ser Phe Pro Asn Glu Tyr His Asn Asn
    210                 215                 220                 
Ala Asp Cys Thr Trp Thr Ile Val Ala Glu Pro Gly Asp Thr Ile Ser
225                 230                 235                 240 
Leu Ile Phe Thr Asp Phe Gln Met Glu Glu Lys Tyr Asp Tyr Leu Glu
                245                 250                 255     
Ile Glu Gly Ser Glu Pro Pro Thr Ile Trp Leu Ser Gly Met Asn Ile
            260                 265                 270         
Pro Pro Pro Ile Ile Ser Asn Lys Asn Trp Leu Arg Leu His Phe Val
        275                 280                 285             
Thr Asp Ser Asn His Arg Tyr Arg Gly Phe Ser Ala Pro Tyr Gln Gly
    290                 295                 300                 
Ser Ser Thr Leu Thr His Thr Thr Ser Thr Gly Glu Leu Glu Glu His
305                 310                 315                 320 
Asn Arg Thr Thr Thr Gly Ala Ile Ala Val Ala Ser Thr Pro Ala Asp
                325                 330                 335     
Val Thr Val Ser Ser Val Thr Ala Val Thr Ile His Arg Leu Ser Glu
            340                 345                 350         
Glu Gln Arg Val Gln Val Thr Ser Leu Arg Asn Ser Gly Leu Asp Pro
        355                 360                 365             
Asn Thr Ser Lys Asp Gly Leu Ser Pro His Pro Ala Asp Thr Gln Ser
    370                 375                 380                 
Thr Arg Arg Arg Pro Arg His Ala Glu Gln Ile Glu Arg Thr Lys Glu
385                 390                 395                 400 
Leu Ala Val Val Thr His Arg Val Lys Lys Ala Ile Asp Phe Lys Ser
                405                 410                 415     
Arg Gly Phe Lys Leu Phe Pro Gly Lys Asp Asn Ser Asn Lys Phe Ser
            420                 425                 430         
Ile Leu Asn Glu Gly Gly Ile Lys Thr Ala Ser Asn Leu Cys Pro Asp
        435                 440                 445             
Pro Gly Glu Pro Glu Asn Gly Lys Arg Ile Gly Ser Asp Phe Ser Leu
    450                 455                 460                 
Gly Ser Thr Val Gln Phe Ser Cys Asp Glu Asp Tyr Val Leu Gln Gly
465                 470                 475                 480 
Ala Lys Ser Ile Thr Cys Gln Arg Ile Ala Glu Val Phe Ala Ala Trp
                485                 490                 495     
Ser Asp His Arg Pro Val Cys Lys Val Lys Thr Cys Gly Ser Asn Leu
            500                 505                 510         
Gln Gly Pro Ser Gly Thr Phe Thr Ser Pro Asn Phe Pro Phe Gln Tyr
        515                 520                 525             
Asp Ser Asn Ala Gln Cys Val Trp Val Ile Thr Ala Val Asn Thr Asn
    530                 535                 540                 
Lys Val Ile Gln Ile Asn Phe Glu Glu Phe Asp Leu Glu Ile Gly Tyr
545                 550                 555                 560 
Asp Thr Leu Thr Ile Gly Asp Gly Gly Glu Val Gly Asp Pro Arg Thr
                565                 570                 575     
Val Leu Gln Val Leu Thr Gly Ser Phe Val Pro Asp Leu Ile Val Ser
            580                 585                 590         
Met Ser Ser Gln Met Trp Leu His Leu Gln Thr Asp Glu Ser Val Gly
        595                 600                 605             
Ser Val Gly Phe Lys Val Asn Tyr Lys Glu Ile Glu Lys Glu Ser Cys
    610                 615                 620                 
Gly Asp Pro Gly Thr Pro Leu Tyr Gly Ile Arg Glu Gly Asp Gly Phe
625                 630                 635                 640 
Ser Asn Arg Asp Val Leu Arg Phe Glu Cys Gln Phe Gly Phe Glu Leu
                645                 650                 655     
Ile Gly Glu Lys Ser Ile Val Cys Gln Glu Asn Asn Gln Trp Ser Ala
            660                 665                 670         
Asn Ile Pro Ile Cys Ile Phe Pro Cys Leu Ser Asn Phe Thr Ala Pro
        675                 680                 685             
Met Gly Thr Val Leu Ser Pro Asp Tyr Pro Glu Gly Tyr Gly Asn Asn
    690                 695                 700                 
Leu Asn Cys Ile Trp Thr Ile Ile Ser Asp Pro Gly Ser Arg Ile His
705                 710                 715                 720 
Leu Ser Phe Asn Asp Phe Asp Leu Glu Ser Gln Phe Asp Phe Leu Ala
                725                 730                 735     
Val Lys Asp Gly Asp Ser Pro Glu Ser Pro Ile Leu Gly Thr Phe Thr
            740                 745                 750         
Gly Ala Glu Val Pro Ser His Leu Thr Ser Asn Ser His Ile Leu Arg
        755                 760                 765             
Leu Glu Phe Gln Ala Asp His Ser Met Ser Gly Arg Gly Phe Asn Ile
    770                 775                 780                 
Thr Tyr Asn Thr Phe Gly His Asn Glu Cys Pro Asp Pro Gly Ile Pro
785                 790                 795                 800 
Ile Asn Ala Arg Arg Phe Gly Asp Asn Phe Gln Leu Gly Ser Ser Ile
                805                 810                 815     
Ser Val Ile Cys Glu Glu Gly Phe Ile Lys Thr Gln Gly Thr Glu Thr
            820                 825                 830         
Ile Thr Cys Ile Leu Met Asp Gly Lys Val Met Trp Ser Gly Leu Ile
        835                 840                 845             
Pro Lys Cys Gly Ala Pro Cys Gly Gly His Phe Ser Ala Pro Ser Gly
    850                 855                 860                 
Val Ile Leu Ser Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu Asn
865                 870                 875                 880 
Cys Glu Trp Val Ile Glu Ala Glu Pro Gly His Ser Ile Lys Ile Thr
                885                 890                 895     
Phe Glu Arg Phe Gln Thr Glu Leu Asn Tyr Asp Val Leu Glu Val His
            900                 905                 910         
Asp Gly Pro Asn Leu Leu Ser Pro Leu Leu Gly Ser Tyr Asn Gly Thr
        915                 920                 925             
Gln Val Pro Gln Phe Leu Phe Ser Ser Ser Asn Phe Ile Tyr Leu Leu
    930                 935                 940                 
Phe Thr Thr Asp Asn Ser Arg Ser Asn Asn Gly Phe Lys Ile His Tyr
945                 950                 955                 960 
Glu Ser Val Thr Val Asn Thr Tyr Ser Cys Leu Asp Pro Gly Ile Pro
                965                 970                 975     
Val His Gly Arg Arg Tyr Gly His Asp Phe Ser Ile Gly Ser Thr Val
            980                 985                 990         
Ser Phe Ser Cys Asp Ser Gly Tyr Arg Leu Ser His Glu Glu Pro Leu
        995                 1000                1005            
Leu Cys Glu Lys Asn His Trp Trp Ser His Pro Leu Pro Thr Cys Asp
    1010                1015                1020                
Ala Leu Cys Gly Gly Asp Val Arg Gly Pro Ser Gly Thr Ile Leu Ser
1025                1030                1035                1040
Pro Gly Tyr Pro Glu Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr
                1045                1050                1055    
Val Asp Val Thr His Gly Lys Gly Val Gln Phe Asn Phe His Thr Phe
            1060                1065                1070        
His Leu Glu Asp His His Asp Tyr Leu Leu Ile Thr Glu Asn Gly Ser
        1075                1080                1085            
Phe Thr Gln Pro Leu Ala Arg Leu Thr Gly Ser Asp Leu Pro Pro Thr
    1090                1095                1100                
Ile Asn Ala Gly Leu Tyr Gly Asn Phe Arg Ala Gln Leu Arg Phe Ile
1105                1110                1115                1120
Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu
                1125                1130                1135    
Tyr Asn Leu Glu Pro Cys Glu Asp Pro Gly Ile Pro Gln Tyr Gly Ser
            1140                1145                1150        
Arg Ile Gly Phe Asn Phe Gly Ile Gly Asp Thr Leu Thr Phe Ser Cys
        1155                1160                1165            
Ser Ser Gly Tyr Arg Leu Glu Gly Thr Ser Glu Ile Ile Cys Leu Gly
    1170                1175                1180                
Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys Val Ala Glu
1185                1190                1195                1200
Cys Gly Ala Ser Ala Thr Asn Asn Glu Gly Ile Leu Leu Ser Pro Asn
                1205                1210                1215    
Tyr Pro Leu Asn Tyr Glu Asn Asn His Glu Cys Ile Tyr Ser Ile Gln
            1220                1225                1230        
Val Gln Ala Gly Lys Gly Ile Asn Ile Ser Ala Arg Thr Phe His Leu
        1235                1240                1245            
Ala Gln Gly Asp Val Leu Lys Ile Tyr Asp Gly Lys Asp Lys Thr Thr
    1250                1255                1260                
His Leu Leu Gly Ala Phe Thr Gly Ala Ser Met Arg Gly Leu Thr Leu
1265                1270                1275                1280
Ser Ser Thr Ser Asn Gln Leu Trp Leu Glu Phe Asn Ser Asp Thr Glu
                1285                1290                1295    
Gly Thr Asp Glu Gly Phe Gln Leu Val Tyr Thr Ser Phe Glu Leu Ser
            1300                1305                1310        
His Cys Glu Asp Pro Gly Ile Pro Gln Phe Gly Tyr Lys Ile Ser Asp
        1315                1320                1325            
Gln Gly His Phe Ala Gly Ser Thr Ile Ile Tyr Gly Cys Asn Pro Gly
    1330                1335                1340                
Tyr Thr Leu His Gly Ser Ser Leu Leu Lys Cys Met Thr Gly Glu Arg
1345                1350                1355                1360
Arg Ala Trp Asp Tyr Pro Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly
                1365                1370                1375    
Arg Phe Lys Gly Glu Ser Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro
            1380                1385                1390        
Phe Pro Tyr Asp Asn Asn Leu Arg Cys Met Trp Met Ile Glu Val Asp
        1395                1400                1405            
Pro Gly Asn Ile Val Ser Leu Gln Phe Leu Ala Phe Asp Thr Glu Ala
    1410                1415                1420                
Ser His Asp Ile Leu Arg Val Trp Asp Gly Pro Pro Glu Asn Asp Met
1425                1430                1435                1440
Leu Leu Lys Glu Ile Ser Gly Ser Leu Ile Pro Glu Gly Ile His Ser
                1445                1450                1455    
Thr Leu Asn Ile Val Thr Ile Gln Phe Asp Thr Asp Phe Tyr Ile Ser
            1460                1465                1470        
Lys Ser Gly Phe Ala Ile Gln Phe Ser Ser Ser Val Ala Thr Ala Cys
        1475                1480                1485            
Arg Asp Pro Gly Val Pro Met Asn Gly Thr Arg Asn Gly Asp Gly Arg
    1490                1495                1500                
Glu Pro Gly Asp Thr Val Val Phe Gln Cys Asp Pro Gly Tyr Glu Leu
1505                1510                1515                1520
Gln Gly Glu Glu Arg Ile Thr Cys Ile Gln Val Glu Asn Arg Tyr Phe
                1525                1530                1535    
Trp Gln Pro Ser Pro Pro Val Cys Ile Ala Pro Cys Gly Gly Asn Leu
            1540                1545                1550        
Thr Gly Ser Ser Gly Phe Ile Leu Ser Pro Asn Phe Pro His Pro Tyr
        1555                1560                1565            
Pro His Ser Arg Asp Cys Asp Trp Thr Ile Thr Val Asn Ala Asp Tyr
    1570                1575                1580                
Val Ile Ser Leu Ala Phe Ile Ser Phe Ser Ile Glu Pro Asn Tyr Asp
1585                1590                1595                1600
Phe Leu Tyr Ile Tyr Asp Gly Pro Asp Ser Asn Ser Pro Leu Ile Gly
                1605                1610                1615    
Ser Phe Gln Asp Ser Lys Leu Pro Glu Arg Ile Glu Ser Ser Ser Asn
            1620                1625                1630        
Thr Met His Leu Ala Phe Arg Ser Asp Gly Ser Val Ser Tyr Thr Gly
        1635                1640                1645            
Phe His Leu Glu Tyr Lys Ala Lys Leu Arg Glu Ser Cys Phe Asp Pro
    1650                1655                1660                
Gly Asn Ile Met Asn Gly Thr Arg Leu Gly Met Asp Tyr Lys Leu Gly
1665                1670                1675                1680
Ser Thr Val Thr Tyr Tyr Cys Asp Ala Gly Tyr Val Leu Gln Gly Tyr
                1685                1690                1695    
Ser Thr Leu Thr Cys Ile Met Gly Asp Asp Gly Arg Pro Gly Trp Asn
            1700                1705                1710        
Arg Ala Leu Pro Ser Cys His Ala Pro Cys Gly Ser Arg Ser Thr Gly
        1715                1720                1725            
Ser Glu Gly Thr Val Leu Ser Pro Asn Tyr Pro Lys Asn Tyr Ser Val
    1730                1735                1740                
Gly His Asn Cys Val Tyr Ser Ile Ala Val Pro Lys Glu Phe Val Val
1745                1750                1755                1760
Phe Gly Gln Phe Val Phe Phe Gln Thr Ser Leu His Asp Val Val Glu
                1765                1770                1775    
Val Tyr Asp Gly Pro Thr Gln Gln Ser Ser Leu Leu Ser Ser Leu Ser
            1780                1785                1790        
Gly Ser His Ser Gly Glu Ser Leu Pro Leu Ser Ser Gly Asn Gln Ile
        1795                1800                1805            
Thr Ile Arg Phe Thr Ser Val Gly Pro Ile Thr Ala Lys Gly Phe His
    1810                1815                1820                
Phe Val Tyr Gln Ala Val Pro Arg Thr Ser Ser Thr Gln Cys Ser Ser
1825                1830                1835                1840
Val Pro Glu Pro Arg Phe Gly Arg Arg Ile Gly Asn Glu Phe Ala Val
                1845                1850                1855    
Gly Ser Ser Val Leu Phe Asp Cys Asn Pro Gly Tyr Ile Leu His Gly
            1860                1865                1870        
Ser Ile Ala Ile Arg Cys Glu Thr Val Pro Asn Ser Leu Ala Gln Trp
        1875                1880                1885            
Asn Asp Ser Leu Pro Thr Cys Ile Val Pro Cys Gly Gly Ile Leu Thr
    1890                1895                1900                
Lys Arg Lys Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu Pro Tyr Asp
1905                1910                1915                1920
Asn Asn Leu Asn Cys Val Trp Lys Ile Thr Val Pro Glu Gly Ala Gly
                1925                1930                1935    
Ile Gln Val Gln Val Val Ser Phe Ala Thr Glu His Asn Trp Asp Ser
            1940                1945                1950        
Leu Asp Phe Tyr Asp Gly Gly Asp Asn Asn Ala Pro Arg Leu Gly Ser
        1955                1960                1965            
Tyr Ser Gly Thr Thr Ile Pro His Leu Leu Asn Ser Thr Ser Asn Asn
    1970                1975                1980                
Leu Tyr Leu Asn Phe Gln Ser Asp Ile Ser Val Ser Ala Ala Gly Phe
1985                1990                1995                2000
His Leu Glu Tyr Thr Ala Ile Gly Leu Asp Ser Cys Pro Glu Pro Gln
                2005                2010                2015    
Thr Pro Ser Ser Gly Ile Lys Ile Gly Asp Arg Tyr Met Val Gly Asp
            2020                2025                2030        
Val Val Ser Phe Gln Cys Asp Gln Gly Tyr Ser Leu Gln Gly His Ser
        2035                2040                2045            
His Ile Thr Cys Met Pro Gly Pro Val Arg Arg Trp Asn Tyr Pro Ile
    2050                2055                2060                
Pro Ile Cys Leu Ala Gln Cys Gly Gly Ala Met Ser Asp Phe Ser Gly
2065                2070                2075                2080
Val Ile Leu Ser Pro Gly Phe Pro Gly Asn Tyr Pro Ser Ser Leu Asp
                2085                2090                2095    
Cys Thr Trp Thr Ile Asn Leu Pro Ile Gly Phe Gly Val His Leu Gln
            2100                2105                2110        
Phe Val Asn Phe Ser Thr Glu Thr Ile His Asp Tyr Leu Glu Val Arg
        2115                2120                2125            
Ser Gly Ser Ser Glu Thr Ser Thr Val Ile Gly Arg Leu Ser Gly Pro
    2130                2135                2140                
Gln Ile Pro Ser Ser Leu Phe Ser Thr Thr His Glu Thr Ser Leu Tyr
2145                2150                2155                2160
Phe His Ser Asp Tyr Ser Gln Asn Lys Gln Gly Phe His Ile Val Tyr
                2165                2170                2175    
Gln Ala Tyr Gln Leu Gln Ser Cys Pro Asp Pro Arg Pro Phe Arg Asn
            2180                2185                2190        
Gly Phe Val Ile Gly Asn Asp Phe Thr Val Gly Gln Thr Ile Ser Phe
        2195                2200                2205            
Glu Cys Phe Pro Gly Tyr Thr Leu Ile Gly Asn Ser Ala Leu Thr Cys
    2210                2215                2220                
Leu His Gly Val Ser Arg Asn Trp Asn His Pro Leu Pro Arg Cys Glu
2225                2230                2235                2240
Ala Leu Cys Gly Gly Asn Ile Thr Ala Met Asn Gly Thr Ile Tyr Ser
                2245                2250                2255    
Pro Gly Tyr Pro Asp Glu Tyr Pro Asn Phe Gln Asp Cys Phe Trp Leu
            2260                2265                2270        
Val Arg Val Pro Pro Gly Asn Gly Ile Tyr Ile Asn Phe Thr Val Leu
        2275                2280                2285            
Gln Thr Glu Pro Ile Tyr Asp Phe Ile Thr Val Trp Asp Gly Pro Asp
    2290                2295                2300                
Gln Asn Ser Pro Gln Ile Gly Gln Phe Ser Gly Asn Thr Ala Leu Glu
2305                2310                2315                2320
Ser Val Tyr Ser Thr Ser Asn Gln Ile Leu Ile Lys Phe His Ser Asp
                2325                2330                2335    
Phe Thr Thr Ser Gly Phe Phe Val Leu Ser Tyr His Ala Tyr Gln Leu
            2340                2345                2350        
Arg Val Cys Gln Pro Pro Pro Pro Val Pro Asn Ala Glu Ile Leu Thr
        2355                2360                2365            
Glu Asp Asp Glu Phe Glu Ile Gly Asp Ile Ile Arg Tyr Gln Cys Leu
    2370                2375                2380                
Pro Gly Phe Thr Leu Val Gly Asn Ala Ile Leu Thr Cys Arg Leu Gly
2385                2390                2395                2400
Glu Arg Leu Gln Met Asp Gly Ala Pro Pro Val Cys Gln Val Leu Cys
                2405                2410                2415    
Pro Ala Asn Glu Leu Arg Leu Asp Ser Thr Gly Val Ile Leu Ser Pro
            2420                2425                2430        
Gly Tyr Pro Asp Ser Tyr Pro Asn Leu Gln Met Cys Ala Trp Ser Ile
        2435                2440                2445            
Ser Val Glu Lys Gly Tyr Asn Ile Thr Met Phe Val Glu Phe Phe Gln
    2450                2455                2460                
Thr Glu Lys Glu Phe Asp Val Leu Gln Val Tyr Asp Gly Pro Asn Ile
2465                2470                2475                2480
Gln Ser Pro Val Leu Ile Ser Leu Ser Gly Asp Tyr Ser Ser Ala Phe
                2485                2490                2495    
Asn Ile Thr Ser Asn Gly His Glu Val Phe Leu Gln Trp Ser Ala Asp
            2500                2505                2510        
His Gly Asn Asn Lys Lys Gly Phe Arg Ile Arg Tyr Ile Ala Phe Tyr
        2515                2520                2525            
Cys Ser Thr Pro Glu Ser Pro Pro His Gly Tyr Ile Ile Ser Gln Thr
    2530                2535                2540                
Gly Gly Gln Leu Asn Ser Val Val Arg Trp Ala Cys Asp Arg Gly Phe
2545                2550                2555                2560
Arg Leu Val Gly Lys Ser Ser Ala Val Cys Arg Lys Ser Ser Tyr Gly
                2565                2570                2575    
Tyr His Ala Trp Asp Ala Pro Val Pro Ala Cys Gln Ala Ile Ser Cys
            2580                2585                2590        
Gly Ile Pro Lys Ala Pro Thr Asn Gly Gly Ile Leu Thr Thr Asp Tyr
        2595                2600                2605            
Leu Val Gly Thr Arg Val Thr Tyr Phe Cys Asn Asp Gly Tyr Arg Leu
    2610                2615                2620                
Ser Ser Lys Glu Leu Thr Thr Ala Val Cys Gln Ser Asp Gly Thr Trp
2625                2630                2635                2640
Ser Asn His Asn Lys Thr Pro Arg Cys Val Val Val Thr Cys Pro Ser
                2645                2650                2655    
Ile Asn Ser Phe Ile Leu Glu His Gly Arg Trp Arg Ile Val Asn Gly
            2660                2665                2670        
Ser His Tyr Glu Tyr Lys Thr Lys Val Val Phe Ser Cys Asp Pro Gly
        2675                2680                2685            
Tyr His Gly Leu Gly Pro Ala Ser Ile Glu Cys Leu Pro Asn Gly Thr
    2690                2695                2700                
Trp Ser Trp Arg Asn Glu Arg Pro Tyr Cys Gln Ile Ile Ser Cys Gly
2705                2710                2715                2720
Glu Leu Pro Thr Pro Pro Asn Gly Asn Lys Ile Gly Thr Gln Thr Ser
                2725                2730                2735    
Tyr Gly Ser Thr Ala Ile Phe Thr Cys Asp Leu Gly Phe Met Leu Val
            2740                2745                2750        
Gly Ser Ala Val Arg Glu Cys Leu Ser Ser Gly Leu Trp Ser Glu Ser
        2755                2760                2765            
Glu Thr Arg Cys Leu Ala Gly His Cys Gly Ile Pro Glu Leu Ile Val
    2770                2775                2780                
Asn Gly Gln Val Ile Gly Glu Asn Tyr Gly Tyr Arg Asp Thr Val Val
2785                2790                2795                2800
Tyr Gln Cys Asn Pro Gly Phe Arg Leu Ile Gly Ser Ser Val Arg Ile
                2805                2810                2815    
Cys Gln Gln Asp His Asn Trp Ser Gly Gln Leu Pro Ser Cys Val Pro
            2820                2825                2830        
Val Ser Cys Gly His Pro Gly Ser Pro Ile Tyr Gly Arg Thr Ser Gly
        2835                2840                2845            
Asn Gly Phe Asn Phe Asn Asp Val Val Thr Phe Ser Cys Asn Ile Gly
    2850                2855                2860                
Tyr Leu Met Gln Gly Pro Thr Lys Ala Gln Cys Gln Ala Asn Arg Gln
2865                2870                2875                2880
Trp Ser His Pro Pro Pro Met Cys Lys Val Val Asn Cys Ser Asp Pro
                2885                2890                2895    
Gly Ile Pro Ala Asn Ser Lys Arg Glu Ser Lys Ile Glu His Gly Asn
            2900                2905                2910        
Phe Thr Tyr Gly Thr Val Val Phe Tyr Asp Cys Asn Pro Gly Tyr Phe
        2915                2920                2925            
Leu Phe Gly Ser Ser Val Leu Ile Cys Gln Pro Asn Gly Gln Trp Asp
    2930                2935                2940                
Lys Pro Leu Pro Glu Cys Ile Met Ile Asp Cys Gly His Pro Gly Val
2945                2950                2955                2960
Pro Pro Asn Ala Val Leu Ser Gly Glu Lys Tyr Thr Phe Gly Ser Thr
                2965                2970                2975    
Val His Tyr Ser Cys Thr Gly Lys Arg Ser Leu Leu Gly Gln Ser Ser
            2980                2985                2990        
Arg Thr Cys Gln Leu Asn Gly His Trp Ser Gly Ser Gln Pro His Cys
        2995                3000                3005            
Ser Gly Asp Ala Thr Gly Thr Cys Gly Asp Pro Gly Thr Pro Gly His
    3010                3015                3020                
Gly Ser Arg Gln Glu Ser Asn Phe Arg Thr Lys Ser Thr Val Arg Tyr
3025                3030                3035                3040
Ala Cys Asp Thr Gly Tyr Ile Leu His Gly Ser Glu Glu Arg Thr Cys
                3045                3050                3055    
Leu Ala Asn Gly Ser Trp Thr Gly Arg Gln Pro Glu Cys Lys Ala Val
            3060                3065                3070        
Gln Cys Gly Asn Pro Gly Thr Thr Ala Asn Gly Lys Val Phe Arg Ile
        3075                3080                3085            
Asp Gly Thr Thr Phe Ser Ser Ser Val Ile Tyr Ser Cys Met Glu Gly
    3090                3095                3100                
Tyr Ile Leu Ser Gly Pro Ser Val Arg Gln Cys Thr Ala Asn Gly Thr
3105                3110                3115                3120
Trp Ser Gly Thr Leu Pro Asn Cys Thr Ile Ile Ser Cys Gly Asp Pro
                3125                3130                3135    
Gly Ile Pro Ala Asn Gly Leu Arg Tyr Gly Asp Asp Tyr Val Val Gly
            3140                3145                3150        
Gln Asn Val Ser Tyr Met Cys Gln Pro Gly Tyr Thr Met Glu Leu Asn
        3155                3160                3165            
Gly Ser Arg Ile Arg Thr Cys Thr Ile Asn Gly Thr Trp Ser Gly Val
    3170                3175                3180                
Met Pro Thr Cys Arg Ala Val Thr Cys Pro Thr Pro Pro Gln Ile Ser
3185                3190                3195                3200
Asn Gly Arg Leu Glu Gly Thr Asn Phe Asp Trp Gly Phe Ser Ile Ser
                3205                3210                3215    
Tyr Ile Cys Ser Pro Gly Tyr Glu Leu Ser Phe Pro Ala Val Leu Thr
            3220                3225                3230        
Cys Val Gly Asn Gly Thr Trp Ser Gly Glu Val Pro Gln Cys Leu Pro
        3235                3240                3245            
Lys Phe Cys Gly Asp Pro Gly Ile Pro Ala Gln Gly Lys Arg Glu Gly
    3250                3255                3260                
Lys Ser Phe Ile Tyr Gln Ser Glu Val Ser Phe Ser Cys Asn Phe Pro
3265                3270                3275                3280
Phe Ile Leu Val Gly Ser Ser Thr Arg Ile Cys Gln Ala Asp Gly Thr
                3285                3290                3295    
Trp Ser Gly Ser Ser Pro His Cys Ile Glu Pro Thr Gln Thr Ser Cys
            3300                3305                3310        
Glu Asn Pro Gly Val Pro Arg His Gly Ser Gln Asn Asn Thr Phe Gly
        3315                3320                3325            
Phe Gln Val Gly Ser Val Val Gln Phe His Cys Lys Lys Gly His Leu
    3330                3335                3340                
Leu Gln Gly Ser Thr Thr Arg Thr Cys Leu Pro Asp Leu Thr Trp Ser
3345                3350                3355                3360
Gly Ile Gln Pro Glu Cys Ile Pro His Ser Cys Lys Gln Pro Glu Thr
                3365                3370                3375    
Pro Ala His Ala Asn Val Val Gly Met Asp Leu Pro Ser His Gly Tyr
            3380                3385                3390        
Thr Leu Ile Tyr Thr Cys Gln Pro Gly Phe Phe Leu Ala Gly Gly Thr
        3395                3400                3405            
Glu His Arg Val Cys Arg Ser Asp Asn Thr Trp Thr Gly Lys Val Pro
    3410                3415                3420                
Ile Cys Glu Ala Gly Ser Lys Ile Leu Val Lys Asp Pro Arg Pro Ala
3425                3430                3435                3440
Leu Gly Thr Pro Ser Pro Lys Leu Ser Val Pro Asp Asp Val Phe Ala
                3445                3450                3455    
Gln Asn Tyr Ile Trp Lys Gly Ser Tyr Asn Phe Lys Gly Arg Lys Gln
            3460                3465                3470        
Pro Met Thr Leu Thr Val Thr Ser Phe Asn Ala Ser Thr Gly Arg Val
        3475                3480                3485            
Asn Ala Thr Leu Ser Asn Ser Asn Met Glu Leu Leu Leu Ser Gly Val
    3490                3495                3500                
Tyr Lys Ser Gln Glu Ala Arg Leu Met Leu Arg Ile Tyr Leu Ile Lys
3505                3510                3515                3520
Val Pro Ala His Ala Ser Val Lys Lys Met Lys Glu Glu Asn Trp Ala
                3525                3530                3535    
Met Asp Gly Phe Val Ser Ala Glu Pro Asp Gly Ala Thr Tyr Val Phe
            3540                3545                3550        
Gln Gly Phe Ile Gln Gly Lys Asp Tyr Gly Gln Phe Gly Leu Gln Arg
        3555                3560                3565            
Leu Gly Leu Asn Met Ser Glu Gly Ser Asn Ser Ser Asn Gln Pro His
    3570                3575                3580                
Gly Thr Asn Ser Ser Ser Val Ala Ile Ala Ile Leu Val Pro Phe Phe
3585                3590                3595                3600
Ala Leu Ile Phe Ala Gly Phe Gly Phe Tyr Leu Tyr Lys Gln Arg Thr
                3605                3610                3615    
Ala Pro Lys Thr Gln Tyr Thr Gly Cys Ser Val His Glu Asn Asn Asn
            3620                3625                3630        
Gly Gln Ala Ala Phe Glu Asn Pro Met Tyr Asp Thr Asn Ala Lys Ser
        3635                3640                3645            
Val Glu Gly Lys Ala Val Arg Phe Asp Pro Asn Leu Asn Thr Val Cys
    3650                3655                3660                
Thr Met Val
3665        


<210> 9281
<211> 3600
<212> PRT
<213> Homo sapiens

<400> 9281
Met Gly Ile Lys Ser Gly Phe Thr Phe Trp Asn Leu Val Phe Leu Leu
 1               5                  10                  15      
Thr Val Ser Cys Val Lys Gly Phe Ile Tyr Thr Cys Gly Gly Thr Leu
            20                  25                  30          
Lys Gly Leu Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro Tyr Gly Tyr
        35                  40                  45              
Pro Asn Gly Ala Asn Cys Thr Trp Val Ile Ile Ala Glu Glu Arg Asn
    50                  55                  60                  
Arg Ile Gln Ile Val Phe Gln Ser Phe Ala Leu Glu Glu Glu Tyr Asp
65                  70                  75                  80  
Tyr Leu Ser Leu Tyr Asp Gly His Pro His Pro Thr Asn Phe Arg Thr
                85                  90                  95      
Arg Leu Thr Gly Phe His Leu Pro Pro Pro Val Thr Ser Thr Lys Ser
            100                 105                 110         
Val Phe Ser Leu Arg Leu Thr Ser Asp Phe Ala Val Ser Ala His Gly
        115                 120                 125             
Phe Lys Val Tyr Tyr Glu Glu Leu Gln Ser Ser Ser Cys Gly Asn Pro
    130                 135                 140                 
Gly Val Pro Pro Lys Gly Val Leu Tyr Gly Thr Arg Phe Asp Val Gly
145                 150                 155                 160 
Asp Lys Ile Arg Tyr Ser Cys Val Thr Gly Tyr Ile Leu Asp Gly His
                165                 170                 175     
Pro Gln Leu Thr Cys Ile Ala Asn Ser Val Asn Thr Ala Ser Trp Asp
            180                 185                 190         
Phe Pro Val Pro Ile Cys Arg Ala Glu Asp Ala Cys Gly Gly Thr Met
        195                 200                 205             
Arg Gly Ser Ser Gly Ile Ile Ser Ser Pro Ser Phe Pro Asn Glu Tyr
    210                 215                 220                 
His Asn Asn Ala Asp Cys Thr Trp Thr Ile Val Ala Glu Pro Gly Asp
225                 230                 235                 240 
Thr Ile Ser Leu Ile Phe Thr Asp Phe Gln Met Glu Glu Lys Tyr Asp
                245                 250                 255     
Tyr Leu Glu Ile Glu Gly Ser Glu Pro Pro Thr Ile Trp Leu Ser Gly
            260                 265                 270         
Met Asn Ile Pro Pro Pro Ile Ile Ser Asn Lys Asn Trp Leu Arg Leu
        275                 280                 285             
His Phe Val Thr Asp Ser Asn His Arg Tyr Arg Gly Phe Ser Ala Pro
    290                 295                 300                 
Tyr Gln Gly Ser Ser Thr Leu Thr His Thr Thr Ser Thr Gly Glu Leu
305                 310                 315                 320 
Glu Glu His Asn Arg Thr Thr Thr Gly Ala Ile Ala Val Ala Ser Thr
                325                 330                 335     
Pro Ala Asp Val Thr Val Ser Ser Val Thr Ala Val Thr Ile His Arg
            340                 345                 350         
Leu Ser Glu Glu Gln Arg Val Gln Val Thr Ser Leu Arg Asn Ser Gly
        355                 360                 365             
Leu Asp Pro Asn Thr Ser Lys Asp Gly Leu Ser Pro His Pro Ala Asp
    370                 375                 380                 
Thr Gln Ser Thr Arg Arg Arg Pro Arg His Ala Glu Gln Ile Glu Arg
385                 390                 395                 400 
Thr Lys Glu Leu Ala Val Val Thr His Arg Val Lys Lys Ala Ile Asp
                405                 410                 415     
Phe Lys Ser Arg Gly Phe Lys Leu Phe Pro Gly Lys Asp Asn Ser Asn
            420                 425                 430         
Lys Phe Ser Ile Leu Asn Glu Gly Gly Ile Lys Thr Ala Ser Asn Leu
        435                 440                 445             
Cys Pro Asp Pro Gly Glu Pro Glu Asn Gly Lys Arg Ile Gly Ser Asp
    450                 455                 460                 
Phe Ser Leu Gly Ser Thr Val Gln Phe Ser Cys Asp Glu Asp Tyr Val
465                 470                 475                 480 
Leu Gln Gly Ala Lys Ser Ile Thr Cys Gln Arg Ile Ala Glu Val Phe
                485                 490                 495     
Ala Ala Trp Ser Asp His Arg Pro Val Cys Lys Val Lys Thr Cys Gly
            500                 505                 510         
Ser Asn Leu Gln Gly Pro Ser Gly Thr Phe Thr Ser Pro Asn Phe Pro
        515                 520                 525             
Phe Gln Tyr Asp Ser Asn Ala Gln Cys Val Trp Val Ile Thr Ala Val
    530                 535                 540                 
Asn Thr Asn Lys Val Ile Gln Ile Asn Phe Glu Glu Phe Asp Leu Glu
545                 550                 555                 560 
Ile Gly Tyr Asp Thr Leu Thr Ile Gly Asp Gly Gly Glu Val Gly Asp
                565                 570                 575     
Pro Arg Thr Val Leu Gln Val Leu Thr Gly Ser Phe Val Pro Asp Leu
            580                 585                 590         
Ile Val Ser Met Ser Ser Gln Met Trp Leu His Leu Gln Thr Asp Glu
        595                 600                 605             
Ser Val Gly Ser Val Gly Phe Lys Val Asn Tyr Lys Glu Ile Glu Lys
    610                 615                 620                 
Glu Ser Cys Gly Asp Pro Gly Thr Pro Leu Tyr Gly Ile Arg Glu Gly
625                 630                 635                 640 
Asp Gly Phe Ser Asn Arg Asp Val Leu Arg Phe Glu Cys Gln Phe Gly
                645                 650                 655     
Phe Glu Leu Ile Gly Glu Lys Ser Ile Val Cys Gln Glu Asn Asn Gln
            660                 665                 670         
Trp Ser Ala Asn Ile Pro Ile Cys Ile Phe Pro Cys Leu Ser Asn Phe
        675                 680                 685             
Thr Ala Pro Met Gly Thr Val Leu Ser Pro Asp Tyr Pro Glu Gly Tyr
    690                 695                 700                 
Gly Asn Asn Leu Asn Cys Ile Trp Thr Ile Ile Ser Asp Pro Gly Ser
705                 710                 715                 720 
Arg Ile His Leu Ser Phe Asn Asp Phe Asp Leu Glu Ser Gln Phe Asp
                725                 730                 735     
Phe Leu Ala Val Lys Asp Gly Asp Ser Pro Glu Ser Pro Ile Leu Gly
            740                 745                 750         
Thr Phe Thr Gly Ala Glu Val Pro Ser His Leu Thr Ser Asn Ser His
        755                 760                 765             
Ile Leu Arg Leu Glu Phe Gln Ala Asp His Ser Met Ser Gly Arg Gly
    770                 775                 780                 
Phe Asn Ile Thr Tyr Asn Thr Phe Gly His Asn Glu Cys Pro Asp Pro
785                 790                 795                 800 
Gly Ile Pro Ile Asn Ala Arg Arg Phe Gly Asp Asn Phe Gln Leu Gly
                805                 810                 815     
Ser Ser Ile Ser Val Ile Cys Glu Glu Gly Phe Ile Lys Thr Gln Gly
            820                 825                 830         
Thr Glu Thr Ile Thr Cys Ile Leu Met Asp Gly Lys Val Met Trp Ser
        835                 840                 845             
Gly Leu Ile Pro Lys Cys Gly Ala Pro Cys Gly Gly His Phe Ser Ala
    850                 855                 860                 
Pro Ser Gly Val Ile Leu Ser Pro Gly Trp Pro Gly Tyr Tyr Lys Asp
865                 870                 875                 880 
Ser Leu Asn Cys Glu Trp Val Ile Glu Ala Glu Pro Gly His Ser Ile
                885                 890                 895     
Lys Ile Thr Phe Glu Arg Phe Gln Thr Glu Leu Asn Tyr Asp Val Leu
            900                 905                 910         
Glu Val His Asp Gly Pro Asn Leu Leu Ser Pro Leu Leu Gly Ser Tyr
        915                 920                 925             
Asn Gly Thr Gln Val Pro Gln Phe Leu Phe Ser Ser Ser Asn Phe Ile
    930                 935                 940                 
Tyr Leu Leu Phe Thr Thr Asp Asn Ser Arg Ser Asn Asn Gly Phe Lys
945                 950                 955                 960 
Ile His Tyr Glu Ser Val Thr Val Asn Thr Tyr Ser Cys Leu Asp Pro
                965                 970                 975     
Gly Ile Pro Val His Gly Arg Arg Tyr Gly His Asp Phe Ser Ile Gly
            980                 985                 990         
Ser Thr Val Ser Phe Ser Cys Asp Ser Gly Tyr Arg Leu Ser His Glu
        995                 1000                1005            
Glu Pro Leu Leu Cys Glu Lys Asn His Trp Trp Ser His Pro Leu Pro
    1010                1015                1020                
Thr Cys Asp Ala Leu Cys Gly Gly Asp Val Arg Gly Pro Ser Gly Thr
1025                1030                1035                1040
Ile Leu Ser Pro Gly Tyr Pro Glu Phe Tyr Pro Asn Ser Leu Asn Cys
                1045                1050                1055    
Thr Trp Thr Val Asp Val Thr His Gly Lys Gly Val Gln Phe Asn Phe
            1060                1065                1070        
His Thr Phe His Leu Glu Asp His His Asp Tyr Leu Leu Ile Thr Glu
        1075                1080                1085            
Asn Gly Ser Phe Thr Gln Pro Leu Ala Arg Leu Thr Gly Ser Asp Leu
    1090                1095                1100                
Pro Pro Thr Ile Asn Ala Gly Leu Tyr Gly Asn Phe Arg Ala Gln Leu
1105                1110                1115                1120
Arg Phe Ile Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn Ile Thr
                1125                1130                1135    
Phe Ser Glu Tyr Asn Leu Glu Pro Cys Glu Asp Pro Gly Ile Pro Gln
            1140                1145                1150        
Tyr Gly Ser Arg Ile Gly Phe Asn Phe Gly Ile Gly Asp Thr Leu Thr
        1155                1160                1165            
Phe Ser Cys Ser Ser Gly Tyr Arg Leu Glu Gly Thr Ser Glu Ile Ile
    1170                1175                1180                
Cys Leu Gly Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys
1185                1190                1195                1200
Val Ala Glu Cys Gly Ala Ser Ala Thr Asn Asn Glu Gly Ile Leu Leu
                1205                1210                1215    
Ser Pro Asn Tyr Pro Leu Asn Tyr Glu Asn Asn His Glu Cys Ile Tyr
            1220                1225                1230        
Ser Ile Gln Val Gln Ala Gly Lys Gly Ile Asn Ile Ser Ala Arg Thr
        1235                1240                1245            
Phe His Leu Ala Gln Gly Asp Val Leu Lys Ile Tyr Asp Gly Lys Asp
    1250                1255                1260                
Lys Thr Thr His Leu Leu Gly Ala Phe Thr Gly Ala Ser Met Arg Gly
1265                1270                1275                1280
Leu Thr Leu Ser Ser Thr Ser Asn Gln Leu Trp Leu Glu Phe Asn Ser
                1285                1290                1295    
Asp Thr Glu Gly Thr Asp Glu Gly Phe Gln Leu Val Tyr Thr Ser Phe
            1300                1305                1310        
Glu Leu Ser His Cys Glu Asp Pro Gly Ile Pro Gln Phe Gly Tyr Lys
        1315                1320                1325            
Ile Ser Asp Gln Gly His Phe Ala Gly Ser Thr Ile Ile Tyr Gly Cys
    1330                1335                1340                
Asn Pro Gly Tyr Thr Leu His Gly Ser Ser Leu Leu Lys Cys Met Thr
1345                1350                1355                1360
Gly Glu Arg Arg Ala Trp Asp Tyr Pro Leu Pro Ser Cys Ile Ala Glu
                1365                1370                1375    
Cys Gly Gly Arg Phe Lys Gly Glu Ser Ser Gly Arg Ile Leu Ser Pro
            1380                1385                1390        
Gly Tyr Pro Phe Pro Tyr Asp Asn Asn Leu Arg Cys Met Trp Met Ile
        1395                1400                1405            
Glu Val Asp Pro Gly Asn Ile Val Ser Leu Gln Phe Leu Ala Phe Asp
    1410                1415                1420                
Thr Glu Ala Ser His Asp Ile Leu Arg Val Trp Asp Gly Pro Pro Glu
1425                1430                1435                1440
Asn Asp Met Leu Leu Lys Glu Ile Ser Gly Ser Leu Ile Pro Glu Gly
                1445                1450                1455    
Ile His Ser Thr Leu Asn Ile Val Thr Ile Gln Phe Asp Thr Asp Phe
            1460                1465                1470        
Tyr Ile Ser Lys Ser Gly Phe Ala Ile Gln Phe Ser Ser Ser Val Ala
        1475                1480                1485            
Thr Ala Cys Arg Asp Pro Gly Val Pro Met Asn Gly Thr Arg Asn Gly
    1490                1495                1500                
Asp Gly Arg Glu Pro Gly Asp Thr Val Val Phe Gln Cys Asp Pro Gly
1505                1510                1515                1520
Tyr Glu Leu Gln Gly Glu Glu Arg Ile Thr Cys Ile Gln Val Glu Asn
                1525                1530                1535    
Arg Tyr Phe Trp Gln Pro Ser Pro Pro Val Cys Ile Ala Pro Cys Gly
            1540                1545                1550        
Gly Asn Leu Thr Gly Ser Ser Gly Phe Ile Leu Ser Pro Asn Phe Pro
        1555                1560                1565            
His Pro Tyr Pro His Ser Arg Asp Cys Asp Trp Thr Ile Thr Val Asn
    1570                1575                1580                
Ala Asp Tyr Val Ile Ser Leu Ala Phe Ile Ser Phe Ser Ile Glu Pro
1585                1590                1595                1600
Asn Tyr Asp Phe Leu Tyr Ile Tyr Asp Gly Pro Asp Ser Asn Ser Pro
                1605                1610                1615    
Leu Ile Gly Ser Phe Gln Asp Ser Lys Leu Pro Glu Arg Ile Glu Ser
            1620                1625                1630        
Ser Ser Asn Thr Met His Leu Ala Phe Arg Ser Asp Gly Ser Val Ser
        1635                1640                1645            
Tyr Thr Gly Phe His Leu Glu Tyr Lys Ala Lys Leu Arg Glu Ser Cys
    1650                1655                1660                
Phe Asp Pro Gly Asn Ile Met Asn Gly Thr Arg Leu Gly Met Asp Tyr
1665                1670                1675                1680
Lys Leu Gly Ser Thr Val Thr Tyr Tyr Cys Asp Ala Gly Tyr Val Leu
                1685                1690                1695    
Gln Gly Tyr Ser Thr Leu Thr Cys Ile Met Gly Asp Asp Gly Arg Pro
            1700                1705                1710        
Gly Trp Asn Arg Ala Leu Pro Ser Cys His Ala Pro Cys Gly Ser Arg
        1715                1720                1725            
Ser Thr Gly Ser Glu Gly Thr Val Leu Ser Pro Asn Tyr Pro Lys Asn
    1730                1735                1740                
Tyr Ser Val Gly His Asn Cys Val Tyr Ser Ile Ala Val Pro Lys Glu
1745                1750                1755                1760
Phe Ala Val Pro Arg Thr Ser Ser Thr Gln Cys Ser Ser Val Pro Glu
                1765                1770                1775    
Pro Arg Phe Gly Arg Arg Ile Gly Asn Glu Phe Ala Val Gly Ser Ser
            1780                1785                1790        
Val Leu Phe Asp Cys Asn Pro Gly Tyr Ile Leu His Gly Ser Ile Ala
        1795                1800                1805            
Ile Arg Cys Glu Thr Val Pro Asn Ser Leu Ala Gln Trp Asn Asp Ser
    1810                1815                1820                
Leu Pro Thr Cys Ile Val Pro Cys Gly Gly Ile Leu Thr Lys Arg Lys
1825                1830                1835                1840
Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu Pro Tyr Asp Asn Asn Leu
                1845                1850                1855    
Asn Cys Val Trp Lys Ile Thr Val Pro Glu Gly Ala Gly Ile Gln Val
            1860                1865                1870        
Gln Val Val Ser Phe Ala Thr Glu His Asn Trp Asp Ser Leu Asp Phe
        1875                1880                1885            
Tyr Asp Gly Gly Asp Asn Asn Ala Pro Arg Leu Gly Ser Tyr Ser Gly
    1890                1895                1900                
Thr Thr Ile Pro His Leu Leu Asn Ser Thr Ser Asn Asn Leu Tyr Leu
1905                1910                1915                1920
Asn Phe Gln Ser Asp Ile Ser Val Ser Ala Ala Gly Phe His Leu Glu
                1925                1930                1935    
Tyr Thr Ala Ile Gly Leu Asp Ser Cys Pro Glu Pro Gln Thr Pro Ser
            1940                1945                1950        
Ser Gly Ile Lys Ile Gly Asp Arg Tyr Met Val Gly Asp Val Val Ser
        1955                1960                1965            
Phe Gln Cys Asp Gln Gly Tyr Ser Leu Gln Gly His Ser His Ile Thr
    1970                1975                1980                
Cys Met Pro Gly Pro Val Arg Arg Trp Asn Tyr Pro Ile Pro Ile Cys
1985                1990                1995                2000
Leu Ala Gln Cys Gly Gly Ala Met Ser Asp Phe Ser Gly Val Ile Leu
                2005                2010                2015    
Ser Pro Gly Phe Pro Gly Asn Tyr Pro Ser Ser Leu Asp Cys Thr Trp
            2020                2025                2030        
Thr Ile Asn Leu Pro Ile Gly Phe Gly Val His Leu Gln Phe Val Asn
        2035                2040                2045            
Phe Ser Thr Glu Thr Ile His Asp Tyr Leu Glu Val Arg Ser Gly Ser
    2050                2055                2060                
Ser Glu Thr Ser Thr Val Ile Gly Arg Leu Ser Gly Pro Gln Ile Pro
2065                2070                2075                2080
Ser Ser Leu Phe Ser Thr Thr His Glu Thr Ser Leu Tyr Phe His Ser
                2085                2090                2095    
Asp Tyr Ser Gln Asn Lys Gln Gly Phe His Ile Val Tyr Gln Ala Tyr
            2100                2105                2110        
Gln Leu Gln Ser Cys Pro Asp Pro Arg Pro Phe Arg Asn Gly Phe Val
        2115                2120                2125            
Ile Gly Asn Asp Phe Thr Val Gly Gln Thr Ile Ser Phe Glu Cys Phe
    2130                2135                2140                
Pro Gly Tyr Thr Leu Ile Gly Asn Ser Ala Leu Thr Cys Leu His Gly
2145                2150                2155                2160
Val Ser Arg Asn Trp Asn His Pro Leu Pro Arg Cys Glu Ala Leu Cys
                2165                2170                2175    
Gly Gly Asn Ile Thr Ala Met Asn Gly Thr Ile Tyr Ser Pro Gly Tyr
            2180                2185                2190        
Pro Asp Glu Tyr Pro Asn Phe Gln Asp Cys Phe Trp Leu Val Arg Val
        2195                2200                2205            
Pro Pro Gly Asn Gly Ile Tyr Ile Asn Phe Thr Val Leu Gln Thr Glu
    2210                2215                2220                
Pro Ile Tyr Asp Phe Ile Thr Val Trp Asp Gly Pro Asp Gln Asn Ser
2225                2230                2235                2240
Pro Gln Ile Gly Gln Phe Ser Gly Asn Thr Ala Leu Glu Ser Val Tyr
                2245                2250                2255    
Ser Thr Ser Asn Gln Ile Leu Ile Lys Phe His Ser Asp Phe Thr Thr
            2260                2265                2270        
Ser Gly Phe Phe Val Leu Ser Tyr His Ala Tyr Gln Leu Arg Val Cys
        2275                2280                2285            
Gln Pro Pro Pro Pro Val Pro Asn Ala Glu Ile Leu Thr Glu Asp Asp
    2290                2295                2300                
Glu Phe Glu Ile Gly Asp Ile Ile Arg Tyr Gln Cys Leu Pro Gly Phe
2305                2310                2315                2320
Thr Leu Val Gly Asn Ala Ile Leu Thr Cys Arg Leu Gly Glu Arg Leu
                2325                2330                2335    
Gln Met Asp Gly Ala Pro Pro Val Cys Gln Val Leu Cys Pro Ala Asn
            2340                2345                2350        
Glu Leu Arg Leu Asp Ser Thr Gly Val Ile Leu Ser Pro Gly Tyr Pro
        2355                2360                2365            
Asp Ser Tyr Pro Asn Leu Gln Met Cys Ala Trp Ser Ile Ser Val Glu
    2370                2375                2380                
Lys Gly Tyr Asn Ile Thr Met Phe Val Glu Phe Phe Gln Thr Glu Lys
2385                2390                2395                2400
Glu Phe Asp Val Leu Gln Val Tyr Asp Gly Pro Asn Ile Gln Ser Pro
                2405                2410                2415    
Val Leu Ile Ser Leu Ser Gly Asp Tyr Ser Ser Ala Phe Asn Ile Thr
            2420                2425                2430        
Ser Asn Gly His Glu Val Phe Leu Gln Trp Ser Ala Asp His Gly Asn
        2435                2440                2445            
Asn Lys Lys Gly Phe Arg Ile Arg Tyr Ile Ala Phe Tyr Cys Ser Thr
    2450                2455                2460                
Pro Glu Ser Pro Pro His Gly Tyr Ile Ile Ser Gln Thr Gly Gly Gln
2465                2470                2475                2480
Leu Asn Ser Val Val Arg Trp Ala Cys Asp Arg Gly Phe Arg Leu Val
                2485                2490                2495    
Gly Lys Ser Ser Ala Val Cys Arg Lys Ser Ser Tyr Gly Tyr His Ala
            2500                2505                2510        
Trp Asp Ala Pro Val Pro Ala Cys Gln Ala Ile Ser Cys Gly Ile Pro
        2515                2520                2525            
Lys Ala Pro Thr Asn Gly Gly Ile Leu Thr Thr Asp Tyr Leu Val Gly
    2530                2535                2540                
Thr Arg Val Thr Tyr Phe Cys Asn Asp Gly Tyr Arg Leu Ser Ser Lys
2545                2550                2555                2560
Glu Leu Thr Thr Ala Val Cys Gln Ser Asp Gly Thr Trp Ser Asn His
                2565                2570                2575    
Asn Lys Thr Pro Arg Cys Val Val Val Thr Cys Pro Ser Ile Asn Ser
            2580                2585                2590        
Phe Ile Leu Glu His Gly Arg Trp Arg Ile Val Asn Gly Ser His Tyr
        2595                2600                2605            
Glu Tyr Lys Thr Lys Val Val Phe Ser Cys Asp Pro Gly Tyr His Gly
    2610                2615                2620                
Leu Gly Pro Ala Ser Ile Glu Cys Leu Pro Asn Gly Thr Trp Ser Trp
2625                2630                2635                2640
Arg Asn Glu Arg Pro Tyr Cys Gln Ile Ile Ser Cys Gly Glu Leu Pro
                2645                2650                2655    
Thr Pro Pro Asn Gly Asn Lys Ile Gly Thr Gln Thr Ser Tyr Gly Ser
            2660                2665                2670        
Thr Ala Ile Phe Thr Cys Asp Leu Gly Phe Met Leu Val Gly Ser Ala
        2675                2680                2685            
Val Arg Glu Cys Leu Ser Ser Gly Leu Trp Ser Glu Ser Glu Thr Arg
    2690                2695                2700                
Cys Leu Ala Gly His Cys Gly Ile Pro Glu Leu Ile Val Asn Gly Gln
2705                2710                2715                2720
Val Ile Gly Glu Asn Tyr Gly Tyr Arg Asp Thr Val Val Tyr Gln Cys
                2725                2730                2735    
Asn Pro Gly Phe Arg Leu Ile Gly Ser Ser Val Arg Ile Cys Gln Gln
            2740                2745                2750        
Asp His Asn Trp Ser Gly Gln Leu Pro Ser Cys Val Pro Val Ser Cys
        2755                2760                2765            
Gly His Pro Gly Ser Pro Ile Tyr Gly Arg Thr Ser Gly Asn Gly Phe
    2770                2775                2780                
Asn Phe Asn Asp Val Val Thr Phe Ser Cys Asn Ile Gly Tyr Leu Met
2785                2790                2795                2800
Gln Gly Pro Thr Lys Ala Gln Cys Gln Ala Asn Arg Gln Trp Ser His
                2805                2810                2815    
Pro Pro Pro Met Cys Lys Val Val Asn Cys Ser Asp Pro Gly Ile Pro
            2820                2825                2830        
Ala Asn Ser Lys Arg Glu Ser Lys Ile Glu His Gly Asn Phe Thr Tyr
        2835                2840                2845            
Gly Thr Val Val Phe Tyr Asp Cys Asn Pro Gly Tyr Phe Leu Phe Gly
    2850                2855                2860                
Ser Ser Val Leu Ile Cys Gln Pro Asn Gly Gln Trp Asp Lys Pro Leu
2865                2870                2875                2880
Pro Glu Cys Ile Met Ile Asp Cys Gly His Pro Gly Val Pro Pro Asn
                2885                2890                2895    
Ala Val Leu Ser Gly Glu Lys Tyr Thr Phe Gly Ser Thr Val His Tyr
            2900                2905                2910        
Ser Cys Thr Gly Lys Arg Ser Leu Leu Gly Gln Ser Ser Arg Thr Cys
        2915                2920                2925            
Gln Leu Asn Gly His Trp Ser Gly Ser Gln Pro His Cys Ser Gly Asp
    2930                2935                2940                
Ala Thr Gly Thr Cys Gly Asp Pro Gly Thr Pro Gly His Gly Ser Arg
2945                2950                2955                2960
Gln Glu Ser Asn Phe Arg Thr Lys Ser Thr Val Arg Tyr Ala Cys Asp
                2965                2970                2975    
Thr Gly Tyr Ile Leu His Gly Ser Glu Glu Arg Thr Cys Leu Ala Asn
            2980                2985                2990        
Gly Ser Trp Thr Gly Arg Gln Pro Glu Cys Lys Ala Val Gln Cys Gly
        2995                3000                3005            
Asn Pro Gly Thr Thr Ala Asn Gly Lys Val Phe Arg Ile Asp Gly Thr
    3010                3015                3020                
Thr Phe Ser Ser Ser Val Ile Tyr Ser Cys Met Glu Gly Tyr Ile Leu
3025                3030                3035                3040
Ser Gly Pro Ser Val Arg Gln Cys Thr Ala Asn Gly Thr Trp Ser Gly
                3045                3050                3055    
Thr Leu Pro Asn Cys Thr Ile Ile Ser Cys Gly Asp Pro Gly Ile Pro
            3060                3065                3070        
Ala Asn Gly Leu Arg Tyr Gly Asp Asp Tyr Val Val Gly Gln Asn Val
        3075                3080                3085            
Ser Tyr Met Cys Gln Pro Gly Tyr Thr Met Glu Leu Asn Gly Ser Arg
    3090                3095                3100                
Ile Arg Thr Cys Thr Ile Asn Gly Thr Trp Ser Gly Val Met Pro Thr
3105                3110                3115                3120
Cys Arg Ala Val Thr Cys Pro Thr Pro Pro Gln Ile Ser Asn Gly Arg
                3125                3130                3135    
Leu Glu Gly Thr Asn Phe Asp Trp Gly Phe Ser Ile Ser Tyr Ile Cys
            3140                3145                3150        
Ser Pro Gly Tyr Glu Leu Ser Phe Pro Ala Val Leu Thr Cys Val Gly
        3155                3160                3165            
Asn Gly Thr Trp Ser Gly Glu Val Pro Gln Cys Leu Pro Lys Phe Cys
    3170                3175                3180                
Gly Asp Pro Gly Ile Pro Ala Gln Gly Lys Arg Glu Gly Lys Ser Phe
3185                3190                3195                3200
Ile Tyr Gln Ser Glu Val Ser Phe Ser Cys Asn Phe Pro Phe Ile Leu
                3205                3210                3215    
Val Gly Ser Ser Thr Arg Ile Cys Gln Ala Asp Gly Thr Trp Ser Gly
            3220                3225                3230        
Ser Ser Pro His Cys Ile Glu Pro Thr Gln Thr Ser Cys Glu Asn Pro
        3235                3240                3245            
Gly Val Pro Arg His Gly Ser Gln Asn Asn Thr Phe Gly Phe Gln Val
    3250                3255                3260                
Gly Ser Val Val Gln Phe His Cys Lys Lys Gly His Leu Leu Gln Gly
3265                3270                3275                3280
Ser Thr Thr Arg Thr Cys Leu Pro Asp Leu Thr Trp Ser Gly Ile Gln
                3285                3290                3295    
Pro Glu Cys Ile Pro His Ser Cys Lys Gln Pro Glu Thr Pro Ala His
            3300                3305                3310        
Ala Asn Val Val Gly Met Asp Leu Pro Ser His Gly Tyr Thr Leu Ile
        3315                3320                3325            
Tyr Thr Cys Gln Pro Gly Phe Phe Leu Ala Gly Gly Thr Glu His Arg
    3330                3335                3340                
Val Cys Arg Ser Asp Asn Thr Trp Thr Gly Lys Val Pro Ile Cys Glu
3345                3350                3355                3360
Ala Gly Ser Lys Ile Leu Val Lys Asp Pro Arg Pro Ala Leu Gly Thr
                3365                3370                3375    
Pro Ser Pro Lys Leu Ser Val Pro Asp Asp Val Phe Ala Gln Asn Tyr
            3380                3385                3390        
Ile Trp Lys Gly Ser Tyr Asn Phe Lys Gly Arg Lys Gln Pro Met Thr
        3395                3400                3405            
Leu Thr Val Thr Ser Phe Asn Ala Ser Thr Gly Arg Val Asn Ala Thr
    3410                3415                3420                
Leu Ser Asn Ser Asn Met Glu Leu Leu Leu Ser Gly Val Tyr Lys Ser
3425                3430                3435                3440
Gln Glu Ala Arg Leu Met Leu Arg Ile Tyr Leu Ile Lys Val Pro Ala
                3445                3450                3455    
His Ala Ser Val Lys Lys Met Lys Glu Glu Asn Trp Ala Met Asp Gly
            3460                3465                3470        
Phe Val Ser Ala Glu Pro Asp Gly Ala Thr Tyr Val Phe Gln Gly Phe
        3475                3480                3485            
Ile Gln Gly Lys Asp Tyr Gly Gln Phe Gly Leu Gln Arg Leu Gly Leu
    3490                3495                3500                
Asn Met Ser Glu Gly Ser Asn Ser Ser Asn Gln Pro His Gly Thr Asn
3505                3510                3515                3520
Ser Ser Ser Val Ala Ile Ala Ile Leu Val Pro Phe Phe Ala Leu Ile
                3525                3530                3535    
Phe Ala Gly Phe Gly Phe Tyr Leu Tyr Lys Gln Arg Thr Ala Pro Lys
            3540                3545                3550        
Thr Gln Tyr Thr Gly Cys Ser Val His Glu Asn Asn Asn Gly Gln Ala
        3555                3560                3565            
Ala Phe Glu Asn Pro Met Tyr Asp Thr Asn Ala Lys Ser Val Glu Gly
    3570                3575                3580                
Lys Ala Val Arg Phe Asp Pro Asn Leu Asn Thr Val Cys Thr Met Val
3585                3590                3595                3600


<210> 9282
<211> 792
<212> PRT
<213> Homo sapiens

<400> 9282
Leu Ser Gly Pro Arg Trp Arg Cys Arg Gly Gly Trp Ala Arg Asp Ala
 1               5                  10                  15      
Phe Thr Val Ser Leu Trp Ser Cys His Pro Arg Pro Arg Asp Thr Gln
            20                  25                  30          
Ala Leu Leu Ser Ala Thr Gln Ala Met Asp Leu Arg Arg Arg Asp Tyr
        35                  40                  45              
His Met Glu Arg Pro Leu Leu Asn Gln Glu His Leu Glu Glu Leu Gly
    50                  55                  60                  
Arg Trp Gly Ser Ala Pro Arg Thr His Gln Trp Arg Thr Trp Leu Gln
65                  70                  75                  80  
Cys Ser Arg Ala Arg Ala Tyr Ala Leu Leu Leu Gln His Leu Pro Val
                85                  90                  95      
Leu Val Trp Leu Pro Arg Tyr Pro Val Arg Asp Trp Leu Leu Gly Asp
            100                 105                 110         
Leu Leu Ser Gly Leu Ser Val Ala Ile Met Gln Leu Pro Gln Gly Leu
        115                 120                 125             
Ala Tyr Ala Leu Leu Ala Gly Leu Pro Pro Val Phe Gly Leu Tyr Ser
    130                 135                 140                 
Ser Phe Tyr Pro Val Phe Ile Tyr Phe Leu Phe Gly Thr Ser Arg His
145                 150                 155                 160 
Ile Ser Val Gly Thr Phe Ala Val Met Ser Val Met Val Gly Ser Val
                165                 170                 175     
Thr Glu Ser Leu Ala Pro Gln Ala Leu Asn Asp Ser Met Ile Asn Glu
            180                 185                 190         
Thr Ala Arg Asp Ala Ala Arg Val Gln Val Ala Ser Thr Leu Ser Val
        195                 200                 205             
Leu Val Gly Leu Phe Gln Val Gly Leu Gly Leu Ile His Phe Gly Phe
    210                 215                 220                 
Val Val Thr Tyr Leu Ser Glu Pro Leu Val Arg Gly Tyr Thr Thr Ala
225                 230                 235                 240 
Ala Ala Val Gln Val Phe Val Ser Gln Leu Lys Tyr Val Phe Gly Leu
                245                 250                 255     
His Leu Ser Ser His Ser Gly Pro Leu Ser Leu Ile Tyr Thr Val Leu
            260                 265                 270         
Glu Val Cys Trp Lys Leu Pro Gln Ser Lys Val Gly Thr Val Val Thr
        275                 280                 285             
Ala Ala Val Ala Gly Val Val Leu Val Val Val Lys Leu Leu Asn Asp
    290                 295                 300                 
Lys Leu Gln Gln Gln Leu Pro Met Pro Ile Pro Gly Glu Leu Leu Thr
305                 310                 315                 320 
Leu Ile Gly Ala Thr Gly Ile Ser Tyr Gly Met Gly Leu Lys His Arg
                325                 330                 335     
Phe Glu Val Asp Val Val Gly Asn Ile Pro Ala Gly Leu Val Pro Pro
            340                 345                 350         
Val Ala Pro Asn Thr Gln Leu Phe Ser Lys Leu Val Gly Ser Ala Phe
        355                 360                 365             
Thr Ile Ala Val Val Gly Phe Ala Ile Ala Ile Ser Leu Gly Lys Ile
    370                 375                 380                 
Phe Ala Leu Arg His Gly Tyr Arg Val Asp Ser Asn Gln Glu Leu Val
385                 390                 395                 400 
Ala Leu Gly Leu Ser Asn Leu Ile Gly Gly Ile Phe Gln Cys Phe Pro
                405                 410                 415     
Val Ser Cys Ser Met Ser Arg Ser Leu Val Gln Glu Ser Thr Gly Gly
            420                 425                 430         
Asn Ser Gln Val Ala Gly Ala Ile Ser Ser Leu Phe Ile Leu Leu Ile
        435                 440                 445             
Ile Val Lys Leu Gly Glu Leu Phe His Asp Leu Pro Lys Ala Val Leu
    450                 455                 460                 
Ala Ala Ile Ile Ile Val Asn Leu Lys Gly Met Leu Arg Gln Leu Ser
465                 470                 475                 480 
Asp Met Arg Ser Leu Trp Lys Ala Asn Arg Ala Asp Leu Leu Ile Trp
                485                 490                 495     
Leu Val Thr Phe Thr Ala Thr Ile Leu Leu Asn Leu Asp Leu Gly Leu
            500                 505                 510         
Val Val Ala Val Ile Phe Ser Leu Leu Leu Val Val Val Arg Thr Gln
        515                 520                 525             
Met Pro His Tyr Ser Val Leu Gly Gln Val Pro Asp Thr Asp Ile Tyr
    530                 535                 540                 
Arg Asp Val Ala Glu Tyr Ser Glu Ala Lys Glu Val Arg Gly Val Lys
545                 550                 555                 560 
Val Phe Arg Ser Ser Ala Thr Val Tyr Phe Ala Asn Ala Glu Phe Tyr
                565                 570                 575     
Ser Asp Ala Leu Lys Gln Arg Cys Gly Val Asp Val Asp Phe Leu Ile
            580                 585                 590         
Ser Gln Lys Lys Lys Leu Leu Lys Lys Gln Glu Gln Leu Lys Leu Lys
        595                 600                 605             
Gln Leu Gln Lys Glu Glu Lys Leu Arg Lys Gln Ala Gly Pro Leu Leu
    610                 615                 620                 
Ser Gly Asp Pro His Leu Leu Pro Pro Ala Ala Ser Pro Lys Gly Ala
625                 630                 635                 640 
Ser Val Ser Ile Asn Val Asn Thr Ser Leu Glu Asp Met Arg Ser Asn
                645                 650                 655     
Asn Val Glu Asp Cys Lys Met Met Gln Val Ser Ser Gly Asp Lys Met
            660                 665                 670         
Glu Asp Ala Thr Ala Asn Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly
        675                 680                 685             
Ser Thr Leu Lys Ala Leu Gly Leu Pro Gln Pro Asp Phe His Ser Leu
    690                 695                 700                 
Ile Leu Asp Leu Gly Ala Leu Ser Phe Val Asp Thr Val Cys Leu Lys
705                 710                 715                 720 
Ser Leu Lys Asn Ile Phe His Asp Phe Arg Glu Ile Glu Val Glu Val
                725                 730                 735     
Tyr Met Ala Ala Cys His Ser Pro Val Val Ser Gln Leu Glu Ala Gly
            740                 745                 750         
His Phe Phe Asp Ala Ser Ile Thr Lys Lys His Leu Phe Ala Ser Val
        755                 760                 765             
His Asp Ala Val Thr Phe Ala Leu Gln His Pro Arg Pro Val Pro Asp
    770                 775                 780                 
Ser Pro Val Ser Val Thr Arg Leu
785                 790         


<210> 9283
<211> 773
<212> PRT
<213> Homo sapiens

<400> 9283
Met Gly Leu Ala Asp Ala Ser Gly Pro Arg Asp Thr Gln Ala Leu Leu
 1               5                  10                  15      
Ser Ala Thr Gln Ala Met Asp Leu Arg Arg Arg Asp Tyr His Met Glu
            20                  25                  30          
Arg Pro Leu Leu Asn Gln Glu His Leu Glu Glu Leu Gly Arg Trp Gly
        35                  40                  45              
Ser Ala Pro Arg Thr His Gln Trp Arg Thr Trp Leu Gln Cys Ser Arg
    50                  55                  60                  
Ala Arg Ala Tyr Ala Leu Leu Leu Gln His Leu Pro Val Leu Val Trp
65                  70                  75                  80  
Leu Pro Arg Tyr Pro Val Arg Asp Trp Leu Leu Gly Asp Leu Leu Ser
                85                  90                  95      
Gly Leu Ser Val Ala Ile Met Gln Leu Pro Gln Gly Leu Ala Tyr Ala
            100                 105                 110         
Leu Leu Ala Gly Leu Pro Pro Val Phe Gly Leu Tyr Ser Ser Phe Tyr
        115                 120                 125             
Pro Val Phe Ile Tyr Phe Leu Phe Gly Thr Ser Arg His Ile Ser Val
    130                 135                 140                 
Gly Thr Phe Ala Val Met Ser Val Met Val Gly Ser Val Thr Glu Ser
145                 150                 155                 160 
Leu Ala Pro Gln Ala Leu Asn Asp Ser Met Ile Asn Glu Thr Ala Arg
                165                 170                 175     
Asp Ala Ala Arg Val Gln Val Ala Ser Thr Leu Ser Val Leu Val Gly
            180                 185                 190         
Leu Phe Gln Val Gly Leu Gly Leu Ile His Phe Gly Phe Val Val Thr
        195                 200                 205             
Tyr Leu Ser Glu Pro Leu Val Arg Gly Tyr Thr Thr Ala Ala Ala Val
    210                 215                 220                 
Gln Val Phe Val Ser Gln Leu Lys Tyr Val Phe Gly Leu His Leu Ser
225                 230                 235                 240 
Ser His Ser Gly Pro Leu Ser Leu Ile Tyr Thr Val Leu Glu Val Cys
                245                 250                 255     
Trp Lys Leu Pro Gln Ser Lys Val Gly Thr Val Val Thr Ala Ala Val
            260                 265                 270         
Ala Gly Val Val Leu Val Val Val Lys Leu Leu Asn Asp Lys Leu Gln
        275                 280                 285             
Gln Gln Leu Pro Met Pro Ile Pro Gly Glu Leu Leu Thr Leu Ile Gly
    290                 295                 300                 
Ala Thr Gly Ile Ser Tyr Gly Met Gly Leu Lys His Arg Phe Glu Val
305                 310                 315                 320 
Asp Val Val Gly Asn Ile Pro Ala Gly Leu Val Pro Pro Val Ala Pro
                325                 330                 335     
Asn Thr Gln Leu Phe Ser Lys Leu Val Gly Ser Ala Phe Thr Ile Ala
            340                 345                 350         
Val Val Gly Phe Ala Ile Ala Ile Ser Leu Gly Lys Ile Phe Ala Leu
        355                 360                 365             
Arg His Gly Tyr Arg Val Asp Ser Asn Gln Glu Leu Val Ala Leu Gly
    370                 375                 380                 
Leu Ser Asn Leu Ile Gly Gly Ile Phe Gln Cys Phe Pro Val Ser Cys
385                 390                 395                 400 
Ser Met Ser Arg Ser Leu Val Gln Glu Ser Thr Gly Gly Asn Ser Gln
                405                 410                 415     
Val Ala Gly Ala Ile Ser Ser Leu Phe Ile Leu Leu Ile Ile Val Lys
            420                 425                 430         
Leu Gly Glu Leu Phe His Asp Leu Pro Lys Ala Val Leu Ala Ala Ile
        435                 440                 445             
Ile Ile Val Asn Leu Lys Gly Met Leu Arg Gln Leu Ser Asp Met Arg
    450                 455                 460                 
Ser Leu Trp Lys Ala Asn Arg Ala Asp Leu Leu Ile Trp Leu Val Thr
465                 470                 475                 480 
Phe Thr Ala Thr Ile Leu Leu Asn Leu Asp Leu Gly Leu Val Val Ala
                485                 490                 495     
Val Ile Phe Ser Leu Leu Leu Val Val Val Arg Thr Gln Met Pro His
            500                 505                 510         
Tyr Ser Val Leu Gly Gln Val Pro Asp Thr Asp Ile Tyr Arg Asp Val
        515                 520                 525             
Ala Glu Tyr Ser Glu Ala Lys Glu Val Arg Gly Val Lys Val Phe Arg
    530                 535                 540                 
Ser Ser Ala Thr Val Tyr Phe Ala Asn Ala Glu Phe Tyr Ser Asp Ala
545                 550                 555                 560 
Leu Lys Gln Arg Cys Gly Val Asp Val Asp Phe Leu Ile Ser Gln Lys
                565                 570                 575     
Lys Lys Leu Leu Lys Lys Gln Glu Gln Leu Lys Leu Lys Gln Leu Gln
            580                 585                 590         
Lys Glu Glu Lys Leu Arg Lys Gln Ala Gly Pro Leu Leu Ser Gly Asp
        595                 600                 605             
Pro His Leu Leu Pro Pro Ala Ala Ser Pro Lys Gly Ala Ser Val Ser
    610                 615                 620                 
Ile Asn Val Asn Thr Ser Leu Glu Asp Met Arg Ser Asn Asn Val Glu
625                 630                 635                 640 
Asp Cys Lys Met Met Gln Val Ser Ser Gly Asp Lys Met Glu Asp Ala
                645                 650                 655     
Thr Ala Asn Gly Gln Glu Asp Ser Lys Ala Pro Asp Gly Ser Thr Leu
            660                 665                 670         
Lys Ala Leu Gly Leu Pro Gln Pro Asp Phe His Ser Leu Ile Leu Asp
        675                 680                 685             
Leu Gly Ala Leu Ser Phe Val Asp Thr Val Cys Leu Lys Ser Leu Lys
    690                 695                 700                 
Asn Ile Phe His Asp Phe Arg Glu Ile Glu Val Glu Val Tyr Met Ala
705                 710                 715                 720 
Ala Cys His Ser Pro Val Val Ser Gln Leu Glu Ala Gly His Phe Phe
                725                 730                 735     
Asp Ala Ser Ile Thr Lys Lys His Leu Phe Ala Ser Val His Asp Ala
            740                 745                 750         
Val Thr Phe Ala Leu Gln His Pro Arg Pro Val Pro Asp Ser Pro Val
        755                 760                 765             
Ser Val Thr Arg Leu
    770             


<210> 9284
<211> 622
<212> PRT
<213> Homo sapiens

<400> 9284
Met Ala Thr Lys Glu Lys Leu Gln Cys Leu Lys Asp Phe His Lys Asp
 1               5                  10                  15      
Ile Leu Lys Pro Ser Pro Gly Lys Ser Pro Gly Thr Arg Pro Glu Asp
            20                  25                  30          
Glu Ala Glu Gly Lys Pro Pro Gln Arg Glu Lys Trp Ser Ser Lys Ile
        35                  40                  45              
Asp Phe Val Leu Ser Val Ala Gly Gly Phe Val Gly Leu Gly Asn Val
    50                  55                  60                  
Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly Ala Phe Leu
65                  70                  75                  80  
Ile Pro Tyr Phe Ile Phe Leu Phe Gly Ser Gly Leu Pro Val Phe Phe
                85                  90                  95      
Leu Glu Ile Ile Ile Gly Gln Tyr Thr Ser Glu Gly Gly Ile Thr Cys
            100                 105                 110         
Trp Glu Lys Ile Cys Pro Leu Phe Ser Gly Ile Gly Tyr Ala Ser Val
        115                 120                 125             
Val Ile Val Ser Leu Leu Asn Val Tyr Tyr Ile Val Ile Leu Ala Trp
    130                 135                 140                 
Ala Thr Tyr Tyr Leu Phe Gln Ser Phe Gln Lys Glu Leu Pro Trp Ala
145                 150                 155                 160 
His Cys Asn His Ser Trp Asn Thr Pro His Cys Met Glu Asp Thr Met
                165                 170                 175     
Arg Lys Asn Lys Ser Val Trp Ile Thr Ile Ser Ser Thr Asn Phe Thr
            180                 185                 190         
Ser Pro Val Ile Glu Phe Trp Glu Arg Asn Val Leu Ser Leu Ser Pro
        195                 200                 205             
Gly Ile Asp His Pro Gly Ser Leu Lys Trp Asp Leu Ala Leu Cys Leu
    210                 215                 220                 
Leu Leu Val Trp Leu Val Cys Phe Phe Cys Ile Trp Lys Gly Val Arg
225                 230                 235                 240 
Ser Thr Gly Lys Val Val Tyr Phe Thr Ala Thr Phe Pro Phe Ala Met
                245                 250                 255     
Leu Leu Val Leu Leu Val Arg Gly Leu Thr Leu Pro Gly Ala Gly Ala
            260                 265                 270         
Gly Ile Lys Phe Tyr Leu Tyr Pro Asp Ile Thr Arg Leu Glu Asp Pro
        275                 280                 285             
Gln Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile
    290                 295                 300                 
Cys Leu Gly Ala Met Thr Ser Leu Gly Ser Tyr Asn Lys Tyr Lys Tyr
305                 310                 315                 320 
Asn Ser Tyr Arg Gln Val Asp Cys Met Leu Leu Gly Cys Leu Asn Ser
                325                 330                 335     
Gly Thr Ser Phe Val Ser Gly Phe Ala Ile Phe Ser Ile Leu Gly Phe
            340                 345                 350         
Met Ala Gln Glu Gln Gly Val Asp Ile Ala Asp Val Ala Glu Ser Gly
        355                 360                 365             
Pro Gly Leu Ala Phe Ile Ala Tyr Pro Lys Ala Val Thr Met Met Pro
    370                 375                 380                 
Leu Pro Thr Phe Trp Ser Ile Leu Phe Phe Ile Met Leu Leu Leu Leu
385                 390                 395                 400 
Gly Leu Asp Ser Gln Phe Val Glu Val Glu Gly Gln Ile Thr Ser Leu
                405                 410                 415     
Val Asp Leu Tyr Pro Ser Phe Leu Arg Lys Gly Tyr Arg Arg Glu Ile
            420                 425                 430         
Phe Ile Ala Phe Val Cys Ser Ile Ser Tyr Leu Leu Gly Leu Thr Met
        435                 440                 445             
Val Thr Glu Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ala
    450                 455                 460                 
Ala Ser Gly Val Cys Leu Leu Trp Val Ala Phe Phe Glu Cys Phe Val
465                 470                 475                 480 
Ile Ala Trp Ile Tyr Gly Gly Asp Asn Leu Tyr Asp Gly Ile Glu Asp
                485                 490                 495     
Met Ile Gly Tyr Arg Pro Gly Pro Trp Met Lys Tyr Ser Trp Ala Val
            500                 505                 510         
Ile Thr Pro Val Leu Cys Val Gly Cys Phe Ile Phe Ser Leu Val Lys
        515                 520                 525             
Tyr Val Pro Leu Thr Tyr Asn Lys Thr Tyr Val Tyr Pro Asn Trp Ala
    530                 535                 540                 
Ile Gly Leu Gly Trp Ser Leu Ala Leu Ser Ser Met Leu Cys Val Pro
545                 550                 555                 560 
Leu Val Ile Val Ile Arg Leu Cys Gln Thr Glu Gly Pro Phe Leu Val
                565                 570                 575     
Arg Val Lys Tyr Leu Leu Thr Pro Arg Glu Pro Asn Arg Trp Ala Val
            580                 585                 590         
Glu Arg Glu Gly Ala Thr Pro Tyr Asn Ser Arg Thr Val Met Asn Gly
        595                 600                 605             
Ala Leu Val Lys Pro Thr His Ile Ile Val Glu Thr Met Met
    610                 615                 620         


<210> 9285
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 9285
Met Asp Gly Asp Ser Ser Ser Ser Ser Gly Gly Ser Gly Pro Ala Pro
 1               5                  10                  15      
Gly Pro Gly Pro Glu Gly Glu Gln Arg Pro Glu Gly Glu Pro Leu Ala
            20                  25                  30          
Pro Asp Gly Gly Ser Pro Asp Ser Thr Gln Thr Lys Ala Val Pro Pro
        35                  40                  45              
Glu Ala Ser Pro Glu Arg Ser Cys Ser Leu His Ser Cys Pro Leu Glu
    50                  55                  60                  
Asp Pro Ser Ser Ser Ser Gly Pro Pro Pro Thr Thr Ser Thr Leu Gln
65                  70                  75                  80  
Pro Val Gly Pro Ser Ser Pro Leu Ala Pro Ala His Phe Thr Tyr Pro
                85                  90                  95      
Arg Ala Leu Gln Glu Tyr Gln Gly Gly Ser Ser Leu Pro Gly Leu Gly
            100                 105                 110         
Asp Arg Ala Ala Leu Cys Ser His Gly Ser Ser Leu Ser Pro Ser Pro
        115                 120                 125             
Ala Pro Ser Gln Arg Asp Gly Thr Trp Lys Pro Pro Ala Val Gln His
    130                 135                 140                 
His Val Val Ser Val Arg Gln Glu Arg Ala Phe Gln Met Pro Lys Ser
145                 150                 155                 160 
Tyr Ser Gln Leu Ile Ala Glu Trp Pro Val Ala Val Leu Met Leu Cys
                165                 170                 175     
Leu Ala Val Ile Phe Leu Cys Thr Leu Ala Gly Leu Leu Gly Ala Arg
            180                 185                 190         
Leu Pro Asp Phe Ser Lys Pro Leu Leu Gly Phe Glu Pro Arg Asp Thr
        195                 200                 205             
Asp Ile Gly Ser Lys Leu Val Val Trp Arg Ala Leu Gln Ala Leu Thr
    210                 215                 220                 
Gly Pro Arg Lys Leu Leu Phe Leu Ser Pro Asp Leu Glu Leu Asn Ser
225                 230                 235                 240 
Ser Ser Ser His Asn Thr Leu Arg Pro Ala Pro Arg Gly Ser Ala Gln
                245                 250                 255     
Glu Ser Ala Val Arg Pro Arg Arg Met Val Glu Pro Leu Glu Asp Arg
            260                 265                 270         
Arg Gln Glu Asn Phe Phe Cys Gly Pro Pro Glu Lys Ser Tyr Ala Lys
        275                 280                 285             
Leu Val Phe Met Ser Thr Ser Ser Gly Ser Leu Trp Asn Leu His Ala
    290                 295                 300                 
Ile His Ser Met Cys Arg Met Glu Gln Asp Gln Ile Arg Ser His Thr
305                 310                 315                 320 
Ser Phe Gly Ala Leu Cys Gln Arg Thr Ala Ala Asn Gln Cys Cys Pro
                325                 330                 335     
Ser Trp Ser Leu Gly Asn Tyr Leu Ala Val Leu Ser Asn Arg Ser Ser
            340                 345                 350         
Cys Leu Asp Thr Thr Gln Ala Asp Ala Ala Arg Thr Leu Ala Leu Leu
        355                 360                 365             
Arg Thr Cys Ala Leu Tyr Tyr His Ser Gly Ala Leu Val Pro Ser Cys
    370                 375                 380                 
Leu Gly Pro Gly Gln Asn Lys Ser Pro Arg Cys Ala Gln Val Pro Thr
385                 390                 395                 400 
Lys Cys Ser Gln Ser Ser Ala Ile Tyr Gln Leu Leu His Phe Leu Leu
                405                 410                 415     
Asp Arg Asp Phe Leu Ser Pro Gln Thr Thr Asp Tyr Gln Val Pro Ser
            420                 425                 430         
Leu Lys Tyr Ser Leu Leu Phe Leu Pro Thr Pro Lys Gly Ala Ser Leu
        435                 440                 445             
Met Asp Ile Tyr Leu Asp Arg Leu Ala Thr Pro Trp Gly Leu Ala Asp
    450                 455                 460                 
Asn Tyr Thr Ser Val Thr Gly Met Asp Leu Gly Leu Lys Gln Glu Leu
465                 470                 475                 480 
Leu Arg His Phe Leu Val Gln Asp Thr Val Tyr Pro Leu Leu Ala Leu
                485                 490                 495     
Val Ala Ile Phe Phe Gly Met Ala Leu Tyr Leu Arg Ser Leu Phe Leu
            500                 505                 510         
Thr Leu Met Val Leu Leu Gly Val Leu Gly Ser Leu Leu Val Ala Phe
        515                 520                 525             
Phe Leu Tyr Gln Val Ala Phe Arg Met Ala Tyr Phe Pro Phe Val Asn
    530                 535                 540                 
Leu Ala Ala Leu Leu Leu Leu Ser Ser Val Cys Ala Asn His Thr Leu
545                 550                 555                 560 
Ile Phe Phe Asp Leu Trp Arg Leu Ser Lys Ser Gln Leu Pro Ser Gly
                565                 570                 575     
Gly Leu Ala Gln Arg Val Gly Arg Thr Met His His Phe Gly Tyr Leu
            580                 585                 590         
Leu Leu Val Ser Gly Leu Thr Thr Ser Ala Ala Phe Tyr Ala Ser Tyr
        595                 600                 605             
Leu Ser Arg Leu Pro Ala Val Arg Cys Leu Ala Leu Phe Met Gly Thr
    610                 615                 620                 
Ala Val Leu Val His Leu Ala Leu Thr Leu Val Trp Leu Pro Ala Ser
625                 630                 635                 640 
Ala Val Leu His Glu Arg Tyr Leu Ala Arg Gly Cys Ala Arg Arg Ala
                645                 650                 655     
Arg Gly Arg Trp Glu Gly Ser Ala Pro Arg Arg Leu Leu Leu Ala Leu
            660                 665                 670         
His Arg Arg Leu Arg Gly Leu Arg Arg Ala Ala Ala Gly Thr Ser Arg
        675                 680                 685             
Leu Leu Phe Gln Arg Leu Leu Pro Cys Gly Val Ile Lys Phe Arg Tyr
    690                 695                 700                 
Ile Trp Ile Cys Trp Phe Ala Ala Leu Ala Ala Gly Gly Ala Tyr Ile
705                 710                 715                 720 
Ala Gly Val Ser Pro Arg Leu Arg Leu Pro Thr Leu Pro Pro Pro Gly
                725                 730                 735     
Gly Gln Val Phe Arg Pro Ser His Pro Phe Glu Arg Phe Asp Ala Glu
            740                 745                 750         
Tyr Arg Gln Leu Phe Leu Phe Glu Gln Leu Pro Gln Gly Glu Gly Gly
        755                 760                 765             
His Met Pro Val Val Leu Val Trp Gly Val Leu Pro Val Asp Thr Gly
    770                 775                 780                 
Asp Pro Leu Asp Pro Arg Ser Asn Ser Ser Leu Val Arg Asp Pro Ala
785                 790                 795                 800 
Phe Ser Ala Ser Gly Pro Glu Ala Gln Arg Trp Leu Leu Ala Leu Cys
                805                 810                 815     
His Arg Ala Arg Asn Gln Ser Phe Phe Asp Thr Leu Gln Glu Gly Trp
            820                 825                 830         
Pro Thr Leu Cys Phe Val Glu Thr Leu Gln Arg Trp Met Glu Ser Pro
        835                 840                 845             
Ser Cys Ala Arg Leu Gly Pro Asp Leu Cys Cys Gly His Ser Asp Phe
    850                 855                 860                 
Pro Trp Ala Pro Gln Phe Phe Leu His Cys Leu Lys Met Met Ala Leu
865                 870                 875                 880 
Glu Gln Gly Pro Asp Gly Thr Gln Asp Leu Gly Leu Arg Phe Asp Ala
                885                 890                 895     
His Gly Ser Leu Ala Ala Leu Val Leu Gln Phe Gln Thr Asn Phe Arg
            900                 905                 910         
Asn Ser Pro Asp Tyr Asn Gln Thr Gln Leu Phe Tyr Asn Glu Val Ser
        915                 920                 925             
His Trp Leu Ala Ala Glu Leu Gly Met Ala Pro Pro Gly Leu Arg Arg
    930                 935                 940                 
Gly Trp Phe Thr Ser Arg Leu Glu Leu Tyr Ser Leu Gln His Ser Leu
945                 950                 955                 960 
Ser Thr Glu Pro Ala Val Val Leu Gly Leu Ala Leu Ala Leu Ala Phe
                965                 970                 975     
Ala Thr Leu Leu Leu Gly Thr Trp Asn Val Pro Leu Ser Leu Phe Ser
            980                 985                 990         
Val Ala Ala Val Ala Gly Thr Val Leu Leu Thr Val Gly Leu Leu Val
        995                 1000                1005            
Leu Leu Glu Trp Gln Leu Asn Thr Ala Glu Ala Leu Phe Leu Ser Ala
    1010                1015                1020                
Ser Val Gly Leu Ser Val Asp Phe Thr Val Asn Tyr Cys Ile Ser Tyr
1025                1030                1035                1040
His Leu Cys Pro His Pro Asp Arg Leu Ser Arg Val Ala Phe Ser Leu
                1045                1050                1055    
Arg Gln Thr Ser Cys Ala Thr Ala Val Gly Ala Ala Ala Leu Phe Ala
            1060                1065                1070        
Ala Gly Val Leu Met Leu Pro Ala Thr Val Leu Leu Tyr Arg Lys Leu
        1075                1080                1085            
Gly Ile Ile Leu Met Met Val Lys Cys Val Ser Cys Gly Phe Ala Ser
    1090                1095                1100                
Phe Phe Phe Gln Ser Leu Cys Cys Phe Phe Gly Pro Glu Lys Asn Cys
1105                1110                1115                1120
Gly Gln Ile Leu Trp Pro Cys Ala His Leu Pro Trp Asp Ala Gly Thr
                1125                1130                1135    
Gly Asp Pro Gly Gly Glu Lys Ala Gly Arg Pro Arg Pro Gly Ser Val
            1140                1145                1150        
Gly Gly Met Pro Gly Ser Cys Ser Glu Gln Tyr Glu Leu Gln Pro Leu
        1155                1160                1165            
Ala Arg Arg Arg Ser Pro Ser Phe Asp Thr Ser Thr Ala Thr Ser Lys
    1170                1175                1180                
Leu Ser His Arg Pro Ser Val Leu Ser Glu Asp Leu Gln Leu His Asp
1185                1190                1195                1200
Gly Pro Cys Cys Ser Arg Pro Pro Pro Ala Pro Ala Ser Pro Arg Glu
                1205                1210                1215    
Leu Leu Leu Asp His Gln Ala Val Phe Ser Gln Cys Pro Ala Leu Gln
            1220                1225                1230        
Thr Ser Ser Pro Tyr Lys Gln Ala Gly Pro Ser Pro Lys Thr Arg Ala
        1235                1240                1245            
Arg Gln Asp Ser Gln Gly Glu Glu Ala Glu Pro Leu Pro Ala Ser Pro
    1250                1255                1260                
Glu Ala Pro Ala His Ser Pro Lys Ala Lys Ala Ala Asp Pro Pro Asp
1265                1270                1275                1280
Gly Phe Cys Ser Ser Ala Ser Thr Leu Glu Gly Leu Ser Val Ser Asp
                1285                1290                1295    
Glu Thr Cys Leu Ser Thr Ser Glu Pro Ser Ala Arg Val Pro Asp Ser
            1300                1305                1310        
Val Gly Val Ser Pro Asp Asp Leu Asp Asp Thr Gly Gln Pro Val Leu
        1315                1320                1325            
Glu Arg Gly Gln Leu Asn Gly Lys Arg Asp Thr Leu Trp Leu Ala Leu
    1330                1335                1340                
Arg Glu Thr Val Tyr Asp Pro Ser Leu Pro Ala Ser His His Ser Ser
1345                1350                1355                1360
Leu Ser Trp Lys Gly Arg Gly Gly Pro Gly Asp Gly Ser Pro Val Val
                1365                1370                1375    
Leu Pro Asn Ser Gln Pro Asp Leu Pro Asp Val Trp Leu Arg Arg Pro
            1380                1385                1390        
Ser Thr His Thr Ser Gly Tyr Ser Ser
        1395                1400    


<210> 9286
<211> 652
<212> PRT
<213> Homo sapiens

<400> 9286
Met Ala Met Asp Glu Tyr Leu Trp Met Val Ile Leu Gly Phe Ile Ile
 1               5                  10                  15      
Ala Phe Ile Leu Ala Phe Ser Val Gly Ala Asn Asp Val Ala Asn Ser
            20                  25                  30          
Phe Gly Thr Ala Val Gly Ser Gly Val Val Thr Leu Arg Gln Ala Cys
        35                  40                  45              
Ile Leu Ala Ser Ile Phe Glu Thr Thr Gly Ser Val Leu Leu Gly Ala
    50                  55                  60                  
Lys Val Gly Glu Thr Ile Arg Lys Gly Ile Ile Asp Val Asn Leu Tyr
65                  70                  75                  80  
Asn Glu Thr Val Glu Thr Leu Met Ala Gly Glu Val Ser Ala Met Val
                85                  90                  95      
Gly Ser Ala Val Trp Gln Leu Ile Ala Ser Phe Leu Arg Leu Pro Ile
            100                 105                 110         
Ser Gly Thr His Cys Ile Val Gly Ser Thr Ile Gly Phe Ser Leu Val
        115                 120                 125             
Ala Ile Gly Thr Lys Gly Val Gln Trp Met Glu Leu Val Lys Ile Val
    130                 135                 140                 
Ala Ser Trp Phe Ile Ser Pro Leu Leu Ser Gly Phe Met Ser Gly Leu
145                 150                 155                 160 
Leu Phe Val Leu Ile Arg Ile Phe Ile Leu Lys Lys Glu Asp Pro Val
                165                 170                 175     
Pro Asn Gly Leu Arg Ala Leu Pro Val Phe Tyr Ala Ala Thr Ile Ala
            180                 185                 190         
Ile Asn Val Phe Ser Ile Met Tyr Thr Gly Ala Pro Val Leu Gly Leu
        195                 200                 205             
Val Leu Pro Met Trp Ala Ile Ala Leu Ile Ser Phe Gly Val Ala Leu
    210                 215                 220                 
Leu Phe Ala Phe Phe Val Trp Leu Phe Val Cys Pro Trp Met Arg Arg
225                 230                 235                 240 
Lys Ile Thr Gly Lys Leu Gln Lys Glu Gly Ala Leu Ser Arg Val Ser
                245                 250                 255     
Asp Glu Ser Leu Ser Lys Val Gln Glu Ala Glu Ser Pro Val Phe Lys
            260                 265                 270         
Glu Leu Pro Gly Ala Lys Ala Asn Asp Asp Ser Thr Ile Pro Leu Thr
        275                 280                 285             
Gly Ala Ala Gly Glu Thr Leu Gly Thr Ser Glu Gly Thr Ser Ala Gly
    290                 295                 300                 
Ser His Pro Arg Ala Ala Tyr Gly Arg Ala Leu Ser Met Thr His Gly
305                 310                 315                 320 
Ser Val Lys Ser Pro Ile Ser Asn Gly Thr Phe Gly Phe Asp Gly His
                325                 330                 335     
Thr Arg Ser Asp Gly His Val Tyr His Thr Val His Lys Asp Ser Gly
            340                 345                 350         
Leu Tyr Lys Asp Leu Leu His Lys Ile His Ile Asp Arg Gly Pro Glu
        355                 360                 365             
Glu Lys Pro Ala Gln Glu Ser Asn Tyr Arg Leu Leu Arg Arg Asn Asn
    370                 375                 380                 
Ser Tyr Thr Cys Tyr Thr Ala Ala Ile Cys Gly Leu Pro Val His Ala
385                 390                 395                 400 
Thr Phe Arg Ala Ala Asp Ser Ser Ala Pro Glu Asp Ser Glu Lys Leu
                405                 410                 415     
Val Gly Asp Thr Val Ser Tyr Ser Lys Lys Arg Leu Arg Tyr Asp Ser
            420                 425                 430         
Tyr Ser Ser Tyr Cys Asn Ala Val Ala Glu Ala Glu Ile Glu Ala Glu
        435                 440                 445             
Glu Gly Gly Val Glu Met Lys Leu Ala Ser Glu Leu Ala Asp Pro Asp
    450                 455                 460                 
Gln Pro Arg Glu Asp Pro Ala Glu Glu Glu Lys Glu Glu Lys Asp Ala
465                 470                 475                 480 
Pro Glu Val His Leu Leu Phe His Phe Leu Gln Val Leu Thr Ala Cys
                485                 490                 495     
Phe Gly Ser Phe Ala His Gly Gly Asn Asp Val Ser Asn Ala Ile Gly
            500                 505                 510         
Pro Leu Val Ala Leu Trp Leu Ile Tyr Lys Gln Gly Gly Val Thr Gln
        515                 520                 525             
Glu Ala Ala Thr Pro Val Trp Leu Leu Phe Tyr Gly Gly Val Gly Ile
    530                 535                 540                 
Cys Thr Gly Leu Trp Val Trp Gly Arg Arg Val Ile Gln Thr Met Gly
545                 550                 555                 560 
Lys Asp Leu Thr Pro Ile Thr Pro Ser Ser Gly Phe Thr Ile Glu Leu
                565                 570                 575     
Ala Ser Ala Phe Thr Val Val Ile Ala Ser Asn Ile Gly Leu Pro Val
            580                 585                 590         
Ser Thr Thr His Cys Lys Val Gly Ser Val Val Ala Val Gly Trp Ile
        595                 600                 605             
Arg Ser Arg Lys Ala Val Asp Trp Arg Leu Phe Arg Asn Ile Phe Val
    610                 615                 620                 
Ala Trp Phe Val Thr Val Pro Val Ala Gly Leu Phe Ser Ala Ala Val
625                 630                 635                 640 
Met Ala Leu Leu Met Tyr Gly Ile Leu Pro Tyr Val
                645                 650         


<210> 9287
<211> 622
<212> PRT
<213> Homo sapiens

<400> 9287
Met Ser Gln Thr Val Gln Thr Met Glu Phe Phe Gly Tyr Ser Leu Pro
 1               5                  10                  15      
Thr Gly Tyr Leu Phe Leu Leu Leu Gly Thr Ile Leu Tyr Phe Ser Leu
            20                  25                  30          
Lys Ile Ile His Cys Gly Leu Ser Val Val Ser Leu Ser Ser Tyr Ser
        35                  40                  45              
Pro Pro Pro Arg Ser Phe Ser Ser Lys Arg Gly Lys Arg Gly Gly Arg
    50                  55                  60                  
Lys Ile His Ala Phe Val Arg Ala Val Val Glu Met Ser Pro Trp Phe
65                  70                  75                  80  
Leu Gln Gln Trp Arg Gln Val Gly Trp Lys Leu Arg Glu Ala Gly Glu
                85                  90                  95      
Ser Ile Glu Val Leu Lys Leu Trp Gln Leu Val Asp Gln Val Leu Gln
            100                 105                 110         
Asp Pro Met Glu Gly Ile Glu Leu Leu Leu Asn Glu Gly Ser Glu Leu
        115                 120                 125             
Gln Glu Glu Leu Trp Gln Gly Ser Gln Glu Ser Ser Tyr Cys Asn Glu
    130                 135                 140                 
Gln Val Arg Arg Lys Ser Lys Lys Asp Leu Glu Ser Gln Glu Ala Tyr
145                 150                 155                 160 
Val Gly Glu Lys Glu Ala Glu Glu Gly Thr Ser Pro Pro Arg Glu Met
                165                 170                 175     
Pro Arg Ile Tyr Pro Gly Pro Thr Arg Leu Ala Asn Ser Thr Ile Lys
            180                 185                 190         
Asp Glu Ser Pro Pro Arg Tyr Arg Pro Leu Val Leu Pro Lys Phe Pro
        195                 200                 205             
Pro Val Lys Lys Ser Pro Phe Phe Pro His Glu Ile Glu Glu Glu Trp
    210                 215                 220                 
Glu Glu Glu Lys Gly Val Met Glu Gly Val Gly Met Gln Glu Glu Ile
225                 230                 235                 240 
Glu Arg Pro Arg Thr Glu Ser Lys Gln Arg Gly Ala Val Tyr Arg Lys
                245                 250                 255     
Pro Ala Trp Glu Gln Tyr Gln Glu Pro Gly Gln Val Phe Pro Val Ile
            260                 265                 270         
Gln Asp Gln Gln Glu Asn Arg Gly Trp Thr Pro Leu Asp His Lys Leu
        275                 280                 285             
Leu Lys Glu Leu Gln Gln Ser Val Gln Leu Tyr Gly Pro His Ala Ser
    290                 295                 300                 
Tyr Thr Gln Ala Ile Leu Asp Asn Ile Gly Gln Gln Gly Leu Ile Pro
305                 310                 315                 320 
Glu Asp Trp Arg Asn Leu Val Lys Ala Val Leu Gly Gly Gly Asp Phe
                325                 330                 335     
Leu Leu Trp Leu Ala Ala Tyr Lys Glu Phe Ala Arg Glu Tyr Ser Lys
            340                 345                 350         
Gln Asn Tyr Gln Ala Gly Asn Gln Ala Trp Asp Glu Glu Met Leu Ile
        355                 360                 365             
Gly Glu Gly Arg Phe Ala Asn Pro Asp Glu Gln Ala Arg Leu Pro Thr
    370                 375                 380                 
Ala Val Leu Leu Gln Val Arg Glu Ile Ala Arg Arg Ala Trp Lys Val
385                 390                 395                 400 
Ile Pro Arg Lys Gly Glu Ile Arg His Ser Leu Thr Lys Ile Val Gln
                405                 410                 415     
Gly Pro Thr Glu Pro Tyr Ala Asp Phe Val Asn Arg Leu Met Glu Ala
            420                 425                 430         
Ala Gly Asn Ile Phe Glu Thr Val Glu Glu Ala Met Pro Leu Val Arg
        435                 440                 445             
Arg Leu Ala Tyr Glu Gln Ala Asn Lys Thr Cys Arg Glu Ala Leu Arg
    450                 455                 460                 
Pro Trp Gln His Lys Asp Ile Pro Thr Phe Leu Lys Ile Cys Arg Asp
465                 470                 475                 480 
Val Met Asp Asp Val Ala Ser Gly Ser His Ala Ala Val Ala Val Thr
                485                 490                 495     
Arg Gln Phe Arg Gln Asn Met Arg Gly Arg Ile Cys Phe Arg Cys Gly
            500                 505                 510         
Arg Glu Gly His Leu Met Arg Glu Cys Arg Ala Lys Phe Pro Ala Arg
        515                 520                 525             
Asp Arg Gln Gly Ile Glu Asn Ser Arg Arg Pro Gly Leu Cys Pro Arg
    530                 535                 540                 
Cys Arg Arg Gly Asn His Trp Val Ser Glu Cys Tyr Phe Lys Ile Asn
545                 550                 555                 560 
Ser Ala Gly Asn Pro Gln Arg Met Pro Asn Glu Pro Gly Pro Ile Arg
                565                 570                 575     
Arg Ser Gly Val Tyr Gly Gln Gln Gln Lys Asn Gly Met Trp Ala Pro
            580                 585                 590         
Ala Pro Arg Gly Gln Asn Asn Arg Trp Val Pro Arg Ser Gln Asn Gln
        595                 600                 605             
Ile Phe Thr Ala Gln Ser Tyr Glu Pro Pro Asn Ile Arg Tyr
    610                 615                 620         


<210> 9288
<211> 1107
<212> PRT
<213> Homo sapiens

<400> 9288
Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp
 1               5                  10                  15      
Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Ile Leu Ala
            20                  25                  30          
Asn Ala Gln Val Ala Lys Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly
        35                  40                  45              
Phe Cys Glu Leu Ala Gly Phe Ala Arg Thr Glu Val Met Gln Lys Ser
    50                  55                  60                  
Cys Ser Cys Lys Phe Leu Phe Gly Val Glu Thr Asn Glu Gln Leu Met
65                  70                  75                  80  
Leu Gln Ile Glu Lys Ser Leu Glu Glu Lys Thr Glu Phe Lys Gly Glu
                85                  90                  95      
Ile Met Phe Tyr Lys Lys Asn Gly Ser Pro Phe Trp Cys Leu Leu Asp
            100                 105                 110         
Ile Val Pro Ile Lys Asn Glu Lys Gly Asp Val Val Leu Phe Leu Ala
        115                 120                 125             
Ser Phe Lys Asp Ile Thr Asp Thr Lys Val Lys Ile Thr Pro Glu Asp
    130                 135                 140                 
Lys Lys Glu Asp Lys Val Lys Gly Arg Ser Arg Ala Gly Thr His Phe
145                 150                 155                 160 
Asp Ser Ala Arg Arg Arg Ser Arg Ala Val Leu Tyr His Ile Ser Gly
                165                 170                 175     
His Leu Gln Arg Arg Glu Lys Asn Lys Leu Lys Ile Asn Asn Asn Val
            180                 185                 190         
Phe Val Asp Lys Pro Ala Phe Pro Glu Tyr Lys Val Ser Asp Ala Lys
        195                 200                 205             
Lys Ser Lys Phe Ile Leu Leu His Phe Ser Thr Phe Lys Ala Gly Trp
    210                 215                 220                 
Asp Trp Leu Ile Leu Leu Ala Thr Phe Tyr Val Ala Val Thr Val Pro
225                 230                 235                 240 
Tyr Asn Val Cys Phe Ile Gly Asn Asp Asp Leu Ser Thr Thr Arg Ser
                245                 250                 255     
Thr Thr Val Ser Asp Ile Ala Val Glu Ile Leu Phe Ile Ile Asp Ile
            260                 265                 270         
Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser Lys Ser Gly Gln Val Ile
        275                 280                 285             
Phe Glu Ala Arg Ser Ile Cys Ile His Tyr Val Thr Thr Trp Phe Ile
    290                 295                 300                 
Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp Leu Leu Tyr Ala Phe Asn
305                 310                 315                 320 
Val Thr Val Val Ser Leu Val His Leu Leu Lys Thr Val Arg Leu Leu
                325                 330                 335     
Arg Leu Leu Arg Leu Leu Gln Lys Leu Asp Arg Tyr Ser Gln His Ser
            340                 345                 350         
Thr Ile Val Leu Thr Leu Leu Met Ser Met Phe Ala Leu Leu Ala His
        355                 360                 365             
Trp Met Ala Cys Ile Trp Tyr Val Ile Gly Lys Met Glu Arg Glu Asp
    370                 375                 380                 
Asn Ser Leu Leu Lys Trp Glu Val Gly Trp Leu His Glu Leu Gly Lys
385                 390                 395                 400 
Arg Leu Glu Ser Pro Tyr Tyr Gly Asn Asn Thr Leu Gly Gly Pro Ser
                405                 410                 415     
Ile Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe Thr Leu Ser Ser Leu
            420                 425                 430         
Thr Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Ala Glu Lys
        435                 440                 445             
Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Leu
    450                 455                 460                 
Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ser Arg Trp
465                 470                 475                 480 
Ser Leu Tyr His Thr Arg Thr Lys Asp Leu Lys Asp Phe Ile Arg Val
                485                 490                 495     
His His Leu Pro Gln Gln Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln
            500                 505                 510         
Thr Thr Trp Ser Val Asn Asn Gly Ile Asp Ser Asn Glu Leu Leu Lys
        515                 520                 525             
Asp Phe Pro Asp Glu Leu Arg Ser Asp Ile Thr Met His Leu Asn Lys
    530                 535                 540                 
Glu Ile Leu Gln Leu Ser Leu Phe Glu Cys Ala Ser Arg Gly Cys Leu
545                 550                 555                 560 
Arg Ser Leu Ser Leu His Ile Lys Thr Ser Phe Cys Ala Pro Gly Glu
                565                 570                 575     
Tyr Leu Leu Arg Gln Gly Asp Ala Leu Gln Ala Ile Tyr Phe Val Cys
            580                 585                 590         
Ser Gly Ser Met Glu Val Leu Lys Asp Ser Met Val Leu Ala Ile Leu
        595                 600                 605             
Gly Lys Gly Asp Leu Ile Gly Ala Asn Leu Ser Ile Lys Asp Gln Val
    610                 615                 620                 
Ile Lys Thr Asn Ala Asp Val Lys Ala Leu Thr Tyr Cys Asp Leu Gln
625                 630                 635                 640 
Cys Ile Ile Leu Lys Gly Leu Phe Glu Val Leu Asp Leu Tyr Pro Glu
                645                 650                 655     
Tyr Ala His Lys Phe Val Glu Asp Ile Gln His Asp Leu Thr Tyr Asn
            660                 665                 670         
Leu Arg Glu Gly His Glu Ser Asp Val Ile Ser Arg Leu Ser Asn Lys
        675                 680                 685             
Ser Met Val Ser Gln Ser Glu Pro Lys Gly Asn Gly Asn Ile Asn Lys
    690                 695                 700                 
Arg Leu Pro Ser Ile Val Glu Asp Glu Glu Glu Glu Glu Glu Gly Glu
705                 710                 715                 720 
Glu Glu Glu Ala Val Ser Leu Ser Pro Ile Cys Thr Arg Gly Ser Ser
                725                 730                 735     
Ser Arg Asn Lys Lys Val Gly Ser Asn Lys Ala Tyr Leu Gly Leu Ser
            740                 745                 750         
Leu Lys Gln Leu Ala Ser Gly Thr Val Pro Phe His Ser Pro Ile Arg
        755                 760                 765             
Val Ser Arg Ser Asn Ser Pro Lys Thr Lys Gln Glu Ile Asp Pro Pro
    770                 775                 780                 
Asn His Asn Lys Arg Lys Glu Lys Asn Leu Lys Leu Gln Leu Ser Thr
785                 790                 795                 800 
Leu Asn Asn Ala Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly
                805                 810                 815     
Ile Glu Asp Gly Asn Ser Ser Glu Glu Ser Gln Thr Phe Asp Phe Gly
            820                 825                 830         
Ser Glu Arg Ile Arg Ser Glu Pro Arg Ile Ser Pro Pro Leu Gly Asp
        835                 840                 845             
Pro Glu Ile Gly Ala Ala Val Leu Phe Ile Lys Ala Glu Glu Thr Lys
    850                 855                 860                 
Gln Gln Ile Asn Lys Leu Asn Ser Glu Val Thr Thr Leu Thr Gln Glu
865                 870                 875                 880 
Val Ser Gln Leu Gly Lys Asp Met Arg Asn Val Ile Arg Leu Leu Glu
                885                 890                 895     
Asn Val Leu Ser Pro Gln Gln Pro Ser Arg Phe Cys Ser Leu His Ser
            900                 905                 910         
Thr Ser Val Cys Pro Ser Arg Glu Ser Leu Gln Thr Arg Thr Ser Trp
        915                 920                 925             
Ser Ala His Gln Pro Cys Leu His Leu Gln Thr Gly Gly Ala Ala Tyr
    930                 935                 940                 
Thr Gln Ala Gln Leu Cys Ser Ser Asn Ile Thr Ser Asp Ile Trp Ser
945                 950                 955                 960 
Val Asp Pro Ser Ser Val Gly Ser Ser Pro Gln Arg Thr Gly Ala His
                965                 970                 975     
Glu Gln Asn Pro Ala Asp Ser Glu Leu Tyr His Ser Pro Ser Leu Asp
            980                 985                 990         
Tyr Ser Pro Ser His Tyr Gln Val Val Gln Glu Gly His Leu Gln Phe
        995                 1000                1005            
Leu Arg Cys Ile Ser Pro His Ser Asp Ser Thr Leu Thr Pro Leu Gln
    1010                1015                1020                
Ser Ile Ser Ala Thr Leu Ser Ser Ser Val Cys Ser Ser Ser Glu Thr
1025                1030                1035                1040
Ser Leu His Leu Val Leu Pro Ser Arg Ser Glu Glu Gly Ser Phe Ser
                1045                1050                1055    
Gln Gly Thr Val Ser Ser Phe Ser Leu Glu Asn Leu Pro Gly Ser Trp
            1060                1065                1070        
Asn Gln Glu Gly Met Ala Ser Ala Ser Thr Lys Pro Leu Glu Asn Leu
        1075                1080                1085            
Pro Leu Glu Val Val Thr Ser Thr Ala Glu Val Lys Asp Asn Lys Ala
    1090                1095                1100                
Ile Asn Val
1105        


<210> 9289
<211> 848
<212> PRT
<213> Homo sapiens

<400> 9289
Met Asp Glu Gly Thr Gly Leu Gln Pro Gly Ala Gly Glu Gln Leu Glu
 1               5                  10                  15      
Ala Pro Ala Thr Ala Glu Ala Val Gln Glu Arg Cys Glu Pro Glu Thr
            20                  25                  30          
Leu Arg Ser Lys Ser Leu Pro Val Leu Ser Ser Ala Ser Cys Arg Pro
        35                  40                  45              
Ser Leu Ser Pro Thr Ser Gly Asp Ala Asn Pro Ala Phe Gly Cys Val
    50                  55                  60                  
Asp Ser Ser Gly His Gln Glu Leu Lys Gln Gly Pro Asn Pro Leu Ala
65                  70                  75                  80  
Pro Ser Pro Ser Ala Pro Ser Thr Ser Ala Gly Leu Gly Asp Cys Asn
                85                  90                  95      
His Arg Val Asp Leu Ser Lys Thr Phe Ser Val Ser Ser Ala Leu Ala
            100                 105                 110         
Met Leu Gln Glu Arg Arg Cys Leu Tyr Val Val Leu Thr Asp Ser Arg
        115                 120                 125             
Cys Phe Leu Val Cys Met Cys Phe Leu Thr Phe Ile Gln Ala Leu Met
    130                 135                 140                 
Val Ser Gly Tyr Leu Ser Ser Val Ile Thr Thr Ile Glu Arg Arg Tyr
145                 150                 155                 160 
Ser Leu Lys Ser Ser Glu Ser Gly Leu Leu Val Ser Cys Phe Asp Ile
                165                 170                 175     
Gly Asn Leu Val Val Val Val Phe Val Ser Tyr Phe Gly Gly Arg Gly
            180                 185                 190         
Arg Arg Pro Leu Trp Leu Ala Val Gly Gly Leu Leu Ile Ala Phe Gly
        195                 200                 205             
Ala Ala Leu Phe Ala Leu Pro His Phe Ile Ser Pro Pro Tyr Gln Ile
    210                 215                 220                 
Gln Glu Leu Asn Ala Ser Ala Pro Asn Asp Gly Leu Cys Gln Gly Gly
225                 230                 235                 240 
Asn Ser Thr Ala Thr Leu Glu Pro Pro Ala Cys Pro Lys Asp Ser Gly
                245                 250                 255     
Gly Asn Asn His Trp Val Tyr Leu Ala Leu Phe Ile Cys Ala Gln Ile
            260                 265                 270         
Leu Ile Gly Met Gly Ser Thr Pro Ile Tyr Thr Leu Gly Pro Thr Tyr
        275                 280                 285             
Leu Asp Asp Asn Val Lys Lys Glu Asn Ser Ser Leu Tyr Leu Ala Ile
    290                 295                 300                 
Met Tyr Val Met Gly Ala Leu Gly Pro Ala Val Gly Tyr Leu Leu Gly
305                 310                 315                 320 
Gly Leu Leu Ile Gly Phe Tyr Val Asp Pro Arg Asn Pro Val His Leu
                325                 330                 335     
Asp Gln Asn Asp Pro Arg Phe Ile Gly Asn Trp Trp Ser Gly Phe Leu
            340                 345                 350         
Leu Cys Ala Ile Ala Met Phe Leu Val Ile Phe Pro Met Phe Thr Phe
        355                 360                 365             
Pro Lys Lys Leu Pro Pro Arg His Lys Lys Lys Lys Lys Lys Lys Phe
    370                 375                 380                 
Ser Val Asp Ala Val Ser Asp Asp Asp Val Leu Lys Glu Lys Ser Asn
385                 390                 395                 400 
Asn Ser Glu Gln Ala Asp Lys Lys Val Ser Ser Met Gly Phe Gly Lys
                405                 410                 415     
Asp Val Arg Asp Leu Pro Arg Ala Ala Val Arg Ile Leu Ser Asn Met
            420                 425                 430         
Thr Phe Leu Phe Val Ser Leu Ser Tyr Thr Ala Glu Ser Ala Ile Val
        435                 440                 445             
Thr Ala Phe Ile Thr Phe Ile Pro Lys Phe Ile Glu Ser Gln Phe Gly
    450                 455                 460                 
Ile Pro Ala Ser Asn Ala Ser Ile Tyr Thr Gly Val Ile Ile Val Pro
465                 470                 475                 480 
Ser Ala Gly Val Gly Ile Val Leu Gly Gly Tyr Ile Ile Lys Lys Leu
                485                 490                 495     
Lys Leu Gly Ala Arg Glu Ser Ala Lys Leu Ala Met Ile Cys Ser Gly
            500                 505                 510         
Val Ser Leu Leu Cys Phe Ser Thr Leu Phe Ile Val Gly Cys Glu Ser
        515                 520                 525             
Ile Asn Leu Gly Gly Ile Asn Ile Pro Tyr Thr Thr Gly Pro Ser Leu
    530                 535                 540                 
Thr Met Pro His Arg Asn Leu Thr Gly Ser Cys Asn Val Asn Cys Gly
545                 550                 555                 560 
Cys Lys Ile His Glu Tyr Glu Pro Val Cys Gly Ser Asp Gly Ile Thr
                565                 570                 575     
Tyr Phe Asn Pro Cys Leu Ala Gly Cys Val Asn Ser Gly Asn Leu Ser
            580                 585                 590         
Thr Gly Ile Arg Asn Tyr Thr Glu Cys Thr Cys Val Gln Ser Arg Gln
        595                 600                 605             
Val Ile Thr Pro Pro Thr Val Gly Gln Arg Ser Gln Leu Arg Val Val
    610                 615                 620                 
Ile Val Lys Thr Tyr Leu Asn Glu Asn Gly Tyr Ala Val Ser Gly Lys
625                 630                 635                 640 
Cys Lys Arg Thr Cys Asn Thr Leu Ile Pro Phe Leu Val Phe Leu Phe
                645                 650                 655     
Ile Val Thr Phe Ile Thr Ala Cys Ala Gln Pro Ser Ala Ile Ile Val
            660                 665                 670         
Thr Leu Arg Ser Val Glu Asp Glu Glu Arg Pro Phe Ala Leu Gly Met
        675                 680                 685             
Gln Phe Val Leu Leu Arg Thr Leu Ala Tyr Ile Pro Thr Pro Ile Tyr
    690                 695                 700                 
Phe Gly Ala Val Ile Asp Thr Thr Cys Met Leu Trp Gln Gln Glu Cys
705                 710                 715                 720 
Gly Val Gln Gly Ser Cys Trp Glu Tyr Asn Val Thr Ser Phe Arg Phe
                725                 730                 735     
Val Tyr Phe Gly Leu Ala Ala Gly Leu Lys Phe Val Gly Phe Ile Phe
            740                 745                 750         
Ile Phe Leu Ala Trp Tyr Ser Ile Lys Tyr Lys Glu Asp Gly Leu Gln
        755                 760                 765             
Arg Arg Arg Gln Arg Glu Phe Pro Leu Ser Thr Val Ser Glu Arg Val
    770                 775                 780                 
Gly His Pro Asp Asn Ala Arg Thr Arg Ser Cys Pro Ala Phe Ser Thr
785                 790                 795                 800 
Gln Gly Glu Phe His Glu Glu Thr Gly Leu Gln Lys Gly Ile Gln Cys
                805                 810                 815     
Ala Ala Gln Thr Tyr Pro Gly Pro Phe Pro Glu Ala Ile Ser Ser Ser
            820                 825                 830         
Ala Asp Pro Gly Leu Glu Glu Ser Pro Ala Ala Leu Glu Pro Pro Ser
        835                 840                 845             


<210> 9290
<211> 314
<212> PRT
<213> Homo sapiens

<400> 9290
Met Thr Arg Lys Asn Tyr Thr Ser Leu Thr Glu Phe Val Leu Leu Gly
 1               5                  10                  15      
Leu Ala Asp Thr Leu Glu Leu Gln Ile Ile Leu Phe Leu Phe Phe Leu
            20                  25                  30          
Val Ile Tyr Thr Leu Thr Val Leu Gly Asn Leu Gly Met Ile Leu Leu
        35                  40                  45              
Ile Arg Ile Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ala
    50                  55                  60                  
Asn Leu Ser Phe Val Asp Val Cys Asn Ser Thr Thr Ile Thr Pro Lys
65                  70                  75                  80  
Met Leu Ala Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly
                85                  90                  95      
Cys Phe Leu Gln Met Tyr Phe Phe Ile Ser Leu Ala Thr Thr Glu Cys
            100                 105                 110         
Ile Leu Phe Gly Leu Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg
        115                 120                 125             
Pro Leu Leu Tyr Ser Leu Ile Met Ser Arg Thr Val Tyr Leu Lys Met
    130                 135                 140                 
Ala Ala Gly Ala Phe Ala Ala Gly Leu Leu Asn Phe Met Val Asn Thr
145                 150                 155                 160 
Ser His Val Ser Ser Leu Ser Phe Cys Asp Ser Asn Val Ile His His
                165                 170                 175     
Phe Phe Cys Asp Ser Pro Pro Leu Phe Lys Leu Ser Cys Ser Asp Thr
            180                 185                 190         
Ile Leu Lys Glu Ser Ile Ser Ser Ile Leu Ala Gly Val Asn Ile Val
        195                 200                 205             
Gly Thr Leu Leu Val Ile Leu Ser Ser Tyr Ser Tyr Val Leu Phe Ser
    210                 215                 220                 
Ile Phe Ser Met His Ser Gly Glu Gly Arg His Arg Ala Phe Ser Thr
225                 230                 235                 240 
Cys Ala Ser His Leu Thr Ala Ile Ile Leu Phe Tyr Ala Thr Cys Ile
                245                 250                 255     
Tyr Thr Tyr Leu Arg Pro Ser Ser Ser Tyr Ser Leu Asn Gln Asp Lys
            260                 265                 270         
Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu
        275                 280                 285             
Ile Tyr Ser Leu Arg Ser Lys Glu Val Lys Lys Ala Leu Ala Asn Val
    290                 295                 300                 
Ile Ser Arg Lys Arg Thr Ser Ser Phe Leu
305                 310                 


<210> 9291
<211> 520
<212> PRT
<213> Homo sapiens

<400> 9291
Met Gly Pro Gln Arg Arg Leu Ser Pro Ala Gly Ala Ala Leu Leu Trp
 1               5                  10                  15      
Gly Phe Leu Leu Gln Leu Thr Ala Ala Gln Glu Ala Ile Leu His Ala
            20                  25                  30          
Ser Gly Asn Gly Thr Thr Lys Asp Tyr Cys Met Leu Tyr Asn Pro Tyr
        35                  40                  45              
Trp Thr Ala Leu Pro Ser Thr Leu Glu Asn Ala Thr Ser Ile Ser Leu
    50                  55                  60                  
Met Asn Leu Thr Ser Thr Pro Leu Cys Asn Leu Ser Asp Ile Pro Pro
65                  70                  75                  80  
Val Gly Ile Lys Ser Lys Ala Val Val Val Pro Trp Gly Ser Cys His
                85                  90                  95      
Phe Leu Glu Lys Ala Arg Ile Ala Gln Lys Gly Gly Ala Glu Ala Met
            100                 105                 110         
Leu Val Val Asn Asn Ser Val Leu Phe Pro Pro Ser Gly Asn Arg Ser
        115                 120                 125             
Glu Phe Pro Asp Val Lys Ile Leu Ile Ala Phe Ile Ser Tyr Lys Asp
    130                 135                 140                 
Phe Arg Asp Met Asn Gln Thr Leu Gly Asp Asn Ile Thr Val Lys Met
145                 150                 155                 160 
Tyr Ser Pro Ser Trp Pro Asn Phe Asp Tyr Thr Met Val Val Ile Phe
                165                 170                 175     
Val Ile Ala Val Phe Thr Val Ala Leu Gly Gly Tyr Trp Ser Gly Leu
            180                 185                 190         
Val Glu Leu Glu Asn Leu Lys Ala Val Thr Thr Glu Asp Arg Glu Met
        195                 200                 205             
Arg Lys Lys Lys Glu Glu Tyr Leu Thr Phe Ser Pro Leu Thr Val Val
    210                 215                 220                 
Ile Phe Val Val Ile Cys Cys Val Met Met Val Leu Leu Tyr Phe Phe
225                 230                 235                 240 
Tyr Lys Trp Leu Val Tyr Val Met Ile Ala Ile Phe Cys Ile Ala Ser
                245                 250                 255     
Ala Met Ser Leu Tyr Asn Cys Leu Ala Ala Leu Ile His Lys Ile Pro
            260                 265                 270         
Tyr Gly Gln Cys Thr Ile Ala Cys Arg Gly Lys Asn Met Glu Val Arg
        275                 280                 285             
Leu Ile Phe Leu Ser Gly Leu Cys Ile Ala Val Ala Val Val Trp Ala
    290                 295                 300                 
Val Phe Arg Asn Glu Asp Arg Trp Ala Trp Ile Leu Gln Asp Ile Leu
305                 310                 315                 320 
Gly Ile Ala Phe Cys Leu Asn Leu Ile Lys Thr Leu Lys Leu Pro Asn
                325                 330                 335     
Phe Lys Ser Cys Val Ile Leu Leu Gly Leu Leu Leu Leu Tyr Asp Val
            340                 345                 350         
Phe Phe Val Phe Ile Thr Pro Phe Ile Thr Lys Asn Gly Glu Ser Ile
        355                 360                 365             
Met Val Glu Leu Ala Ala Gly Pro Phe Gly Asn Asn Glu Lys Leu Pro
    370                 375                 380                 
Val Val Ile Arg Val Pro Lys Leu Ile Tyr Phe Ser Val Met Ser Val
385                 390                 395                 400 
Cys Leu Met Pro Val Ser Ile Leu Gly Phe Gly Asp Ile Ile Val Pro
                405                 410                 415     
Gly Leu Leu Ile Ala Tyr Cys Arg Arg Phe Asp Val Gln Thr Gly Ser
            420                 425                 430         
Ser Tyr Ile Tyr Tyr Val Ser Ser Thr Val Ala Tyr Ala Ile Gly Met
        435                 440                 445             
Ile Leu Thr Phe Val Val Leu Val Leu Met Lys Lys Gly Gln Pro Ala
    450                 455                 460                 
Leu Leu Tyr Leu Val Pro Cys Thr Leu Ile Thr Ala Ser Val Val Ala
465                 470                 475                 480 
Trp Arg Arg Lys Glu Met Lys Lys Phe Trp Lys Gly Asn Ser Tyr Gln
                485                 490                 495     
Met Met Asp His Leu Asp Cys Ala Thr Asn Glu Glu Asn Pro Val Ile
            500                 505                 510         
Ser Gly Glu Gln Ile Val Gln Gln
        515                 520 


<210> 9292
<211> 633
<212> PRT
<213> Homo sapiens

<400> 9292
Met Ala His Leu Lys Arg Leu Val Lys Leu His Ile Lys Arg His Tyr
 1               5                  10                  15      
His Lys Lys Phe Trp Lys Leu Gly Ala Val Ile Phe Phe Phe Ile Ile
            20                  25                  30          
Val Leu Val Leu Met Gln Arg Glu Val Ser Val Gln Tyr Ser Lys Glu
        35                  40                  45              
Glu Ser Arg Met Glu Arg Asn Met Lys Asn Lys Asn Lys Met Leu Asp
    50                  55                  60                  
Leu Met Leu Glu Ala Val Asn Asn Ile Lys Asp Ala Met Pro Lys Met
65                  70                  75                  80  
Gln Ile Gly Ala Pro Val Arg Gln Asn Ile Asp Ala Gly Glu Arg Pro
                85                  90                  95      
Cys Leu Gln Gly Tyr Tyr Thr Ala Ala Glu Leu Lys Pro Val Leu Asp
            100                 105                 110         
Arg Pro Pro Gln Asp Ser Asn Ala Pro Gly Ala Ser Gly Lys Ala Phe
        115                 120                 125             
Lys Thr Thr Asn Leu Ser Val Glu Glu Gln Lys Glu Lys Glu Arg Gly
    130                 135                 140                 
Glu Ala Lys His Cys Phe Asn Ala Phe Ala Ser Asp Arg Ile Ser Leu
145                 150                 155                 160 
His Arg Asp Leu Gly Pro Asp Thr Arg Pro Pro Glu Cys Ile Glu Gln
                165                 170                 175     
Lys Phe Lys Arg Cys Pro Pro Leu Pro Thr Thr Ser Val Ile Ile Val
            180                 185                 190         
Phe His Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val His Ser Val
        195                 200                 205             
Leu Tyr Ser Ser Pro Ala Ile Leu Leu Lys Glu Ile Ile Leu Val Asp
    210                 215                 220                 
Asp Ala Ser Val Asp Glu Tyr Leu His Asp Lys Leu Asp Glu Tyr Val
225                 230                 235                 240 
Lys Gln Phe Ser Ile Val Lys Ile Val Arg Gln Arg Glu Arg Lys Gly
                245                 250                 255     
Leu Ile Thr Ala Arg Leu Leu Gly Ala Thr Val Ala Thr Ala Glu Thr
            260                 265                 270         
Leu Thr Phe Leu Asp Ala His Cys Glu Cys Phe Tyr Gly Trp Leu Glu
        275                 280                 285             
Pro Leu Leu Ala Arg Ile Ala Glu Asn Tyr Thr Ala Val Val Ser Pro
    290                 295                 300                 
Asp Ile Ala Ser Ile Asp Leu Asn Thr Phe Glu Phe Asn Lys Pro Ser
305                 310                 315                 320 
Pro Tyr Gly Ser Asn His Asn Arg Gly Asn Phe Asp Trp Ser Leu Ser
                325                 330                 335     
Phe Gly Trp Glu Ser Leu Pro Asp His Glu Lys Gln Arg Arg Lys Asp
            340                 345                 350         
Glu Thr Tyr Pro Ile Lys Thr Pro Thr Phe Ala Gly Gly Leu Phe Ser
        355                 360                 365             
Ile Ser Lys Glu Tyr Phe Glu Tyr Ile Gly Ser Tyr Asp Glu Glu Met
    370                 375                 380                 
Glu Ile Trp Gly Gly Glu Asn Ile Glu Met Ser Phe Arg Val Trp Gln
385                 390                 395                 400 
Cys Gly Gly Gln Leu Glu Ile Met Pro Cys Ser Val Val Gly His Val
                405                 410                 415     
Phe Arg Ser Lys Ser Pro His Ser Phe Pro Lys Gly Thr Gln Val Ile
            420                 425                 430         
Ala Arg Asn Gln Val Arg Leu Ala Glu Val Trp Met Asp Glu Tyr Lys
        435                 440                 445             
Glu Ile Phe Tyr Arg Arg Asn Thr Asp Ala Ala Lys Ile Val Lys Gln
    450                 455                 460                 
Lys Ala Phe Gly Asp Leu Ser Lys Arg Phe Glu Ile Lys His Arg Leu
465                 470                 475                 480 
Arg Cys Lys Asn Phe Thr Trp Tyr Leu Asn Asn Ile Tyr Pro Glu Val
                485                 490                 495     
Tyr Val Pro Asp Leu Asn Pro Val Ile Ser Gly Tyr Ile Lys Ser Val
            500                 505                 510         
Gly Gln Pro Leu Cys Leu Asp Val Gly Glu Asn Asn Gln Gly Gly Lys
        515                 520                 525             
Pro Leu Ile Met Tyr Thr Cys His Gly Leu Gly Gly Asn Gln Tyr Phe
    530                 535                 540                 
Glu Tyr Ser Ala Gln His Glu Ile Arg His Asn Ile Gln Lys Glu Leu
545                 550                 555                 560 
Cys Leu His Ala Ala Gln Gly Leu Val Gln Leu Lys Ala Cys Thr Tyr
                565                 570                 575     
Lys Gly His Lys Thr Val Val Thr Gly Glu Gln Ile Trp Glu Ile Gln
            580                 585                 590         
Lys Asp Gln Leu Leu Tyr Asn Pro Phe Leu Lys Met Cys Leu Ser Ala
        595                 600                 605             
Asn Gly Glu His Pro Ser Leu Val Ser Cys Asn Pro Ser Asp Pro Leu
    610                 615                 620                 
Gln Lys Trp Ile Leu Ser Gln Asn Asp
625                 630             


<210> 9293
<211> 3487
<212> PRT
<213> Homo sapiens

<400> 9293
Met Arg Leu Ile Ser Ile Ala Pro Gly Pro Arg Trp Gln Val Gln Ser
 1               5                  10                  15      
His His Pro Arg Ser Ala Gly Gln Asn Cys Thr Phe Gln Leu His Gly
            20                  25                  30          
Pro Asn Gly Thr Val Glu Ser Pro Gly Phe Pro Tyr Gly Tyr Pro Asn
        35                  40                  45              
Tyr Ala Asn Cys Thr Trp Thr Ile Thr Ala Glu Glu Gln His Arg Ile
    50                  55                  60                  
Gln Leu Val Phe Gln Ser Phe Ala Leu Glu Glu Asp Phe Asp Val Leu
65                  70                  75                  80  
Ser Val Phe Asp Gly Pro Pro Gln Pro Glu Asn Leu Arg Thr Arg Leu
                85                  90                  95      
Thr Gly Phe Gln Leu Pro Ala Thr Ile Val Ser Ala Ala Thr Thr Leu
            100                 105                 110         
Ser Leu Arg Leu Ile Ser Asp Tyr Ala Val Ser Ala Gln Gly Phe His
        115                 120                 125             
Ala Thr Tyr Glu Ala Leu Pro Ser His Thr Cys Gly Asn Pro Gly Arg
    130                 135                 140                 
Leu Pro Asn Gly Ile Gln Gln Gly Ser Thr Phe Asn Leu Gly Asp Lys
145                 150                 155                 160 
Val Arg Tyr Ser Cys Asn Leu Gly Phe Phe Leu Glu Gly His Ala Val
                165                 170                 175     
Leu Thr Cys His Ala Gly Ser Glu Asn Ser Ala Thr Trp Asp Phe Pro
            180                 185                 190         
Leu Pro Ser Cys Arg Ala Asp Asp Ala Cys Gly Gly Thr Leu Arg Gly
        195                 200                 205             
Gln Ser Gly Ile Ile Ser Ser Pro His Phe Pro Ser Glu Tyr His Asn
    210                 215                 220                 
Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala Glu Leu Gly Asp Thr Ile
225                 230                 235                 240 
Ala Leu Val Phe Ile Asp Phe Gln Leu Glu Asp Gly Tyr Asp Phe Leu
                245                 250                 255     
Glu Val Thr Gly Thr Glu Gly Ser Ser Leu Trp Phe Thr Gly Ala Ser
            260                 265                 270         
Leu Pro Ala Pro Val Ile Ser Ser Lys Asn Trp Leu Arg Leu His Phe
        275                 280                 285             
Thr Ser Asp Gly Asn His Arg Gln Arg Gly Phe Ser Ala Gln Tyr Gln
    290                 295                 300                 
Val Lys Lys Gln Ile Glu Leu Lys Ser Arg Gly Val Lys Leu Met Pro
305                 310                 315                 320 
Ser Lys Asp Asn Ser Gln Lys Thr Ser Val Leu Thr Gln Val Gly Val
                325                 330                 335     
Ser Gln Gly His Asn Met Cys Pro Asp Pro Gly Ile Pro Glu Arg Gly
            340                 345                 350         
Lys Arg Leu Gly Ser Asp Phe Arg Leu Gly Ser Ser Val Gln Phe Thr
        355                 360                 365             
Cys Asn Glu Gly Tyr Asp Leu Gln Gly Ser Lys Arg Ile Thr Cys Met
    370                 375                 380                 
Lys Val Ser Asp Met Phe Ala Ala Trp Ser Asp His Arg Pro Val Cys
385                 390                 395                 400 
Arg Ala Arg Met Cys Asp Ala His Leu Arg Gly Pro Ser Gly Ile Ile
                405                 410                 415     
Thr Ser Pro Asn Phe Pro Ile Gln Tyr Asp Asn Asn Ala His Cys Val
            420                 425                 430         
Trp Ile Ile Thr Ala Leu Asn Pro Ser Lys Val Ile Lys Leu Ala Phe
        435                 440                 445             
Glu Glu Phe Asp Leu Glu Arg Gly Tyr Asp Thr Leu Thr Val Gly Asp
    450                 455                 460                 
Gly Gly Gln Asp Gly Asp Gln Lys Thr Val Leu Tyr Ile Leu Thr Gly
465                 470                 475                 480 
Thr Ser Val Pro Asp Leu Ile Val Ser Thr Asn His Gln Met Trp Leu
                485                 490                 495     
Leu Phe Gln Thr Asp Gly Ser Gly Ser Ser Leu Gly Phe Lys Ala Ser
            500                 505                 510         
Tyr Glu Glu Ile Glu Gln Gly Ser Cys Gly Asp Pro Gly Ile Pro Ala
        515                 520                 525             
Tyr Gly Arg Arg Glu Gly Ser Arg Phe His His Gly Asp Thr Leu Lys
    530                 535                 540                 
Phe Glu Cys Gln Pro Ala Phe Glu Leu Val Gly Gln Lys Ala Ile Thr
545                 550                 555                 560 
Cys Gln Lys Asn Asn Gln Trp Ser Ala Lys Lys Pro Gly Cys Val Phe
                565                 570                 575     
Ser Cys Phe Phe Asn Phe Thr Ser Pro Ser Gly Val Val Leu Ser Pro
            580                 585                 590         
Asn Tyr Pro Glu Asp Tyr Gly Asn His Leu His Cys Val Trp Leu Ile
        595                 600                 605             
Leu Ala Arg Pro Glu Ser Arg Ile His Leu Ala Phe Asn Asp Ile Asp
    610                 615                 620                 
Val Glu Pro Gln Phe Asp Phe Leu Val Ile Lys Asp Gly Ala Thr Ala
625                 630                 635                 640 
Glu Ala Pro Val Leu Gly Thr Phe Ser Gly Asn Gln Leu Pro Ser Ser
                645                 650                 655     
Ile Thr Ser Ser Gly His Val Ala Arg Leu Glu Phe Gln Thr Asp His
            660                 665                 670         
Ser Thr Gly Lys Arg Gly Phe Asn Ile Thr Phe Thr Thr Phe Arg His
        675                 680                 685             
Asn Glu Cys Pro Asp Pro Gly Val Pro Val Asn Gly Lys Arg Phe Gly
    690                 695                 700                 
Asp Ser Leu Gln Leu Gly Ser Ser Ile Ser Phe Leu Cys Asp Glu Gly
705                 710                 715                 720 
Phe Leu Gly Thr Gln Gly Ser Glu Thr Ile Thr Cys Val Leu Lys Glu
                725                 730                 735     
Gly Ser Val Val Trp Asn Ser Ala Val Leu Arg Cys Glu Ala Pro Cys
            740                 745                 750         
Gly Gly His Leu Thr Ser Pro Ser Gly Thr Ile Leu Ser Pro Gly Trp
        755                 760                 765             
Pro Gly Phe Tyr Lys Asp Ala Leu Ser Cys Ala Trp Val Ile Glu Ala
    770                 775                 780                 
Gln Pro Gly Tyr Pro Ile Lys Ile Thr Phe Asp Arg Phe Lys Thr Glu
785                 790                 795                 800 
Val Asn Tyr Asp Thr Leu Glu Val Arg Asp Gly Arg Thr Tyr Ser Ala
                805                 810                 815     
Pro Leu Ile Gly Val Tyr His Gly Thr Gln Val Pro Gln Phe Leu Ile
            820                 825                 830         
Ser Thr Ser Asn Tyr Leu Tyr Leu Leu Phe Ser Thr Asp Lys Ser His
        835                 840                 845             
Ser Asp Ile Gly Phe Gln Leu Arg Tyr Glu Thr Ile Thr Leu Gln Ser
    850                 855                 860                 
Asp His Cys Leu Asp Pro Gly Ile Pro Val Asn Gly Gln Arg His Gly
865                 870                 875                 880 
Asn Asp Phe Tyr Val Gly Ala Leu Val Thr Phe Ser Cys Asp Ser Gly
                885                 890                 895     
Tyr Thr Leu Ser Asp Gly Glu Pro Leu Glu Cys Glu Pro Asn Phe Gln
            900                 905                 910         
Trp Ser Arg Ala Leu Pro Ser Cys Glu Ala Leu Cys Gly Gly Phe Ile
        915                 920                 925             
Gln Gly Ser Ser Gly Thr Ile Leu Ser Pro Gly Phe Pro Asp Phe Tyr
    930                 935                 940                 
Pro Asn Asn Leu Asn Cys Thr Trp Ile Ile Glu Thr Ser His Gly Lys
945                 950                 955                 960 
Gly Val Phe Phe Thr Phe His Thr Phe His Leu Glu Ser Gly His Asp
                965                 970                 975     
Tyr Leu Leu Ile Thr Glu Asn Gly Ser Phe Thr Gln Pro Leu Arg Gln
            980                 985                 990         
Leu Thr Gly Ser Arg Leu Pro Ala Pro Ile Ser Ala Gly Leu Tyr Gly
        995                 1000                1005            
Asn Phe Thr Ala Gln Val Arg Phe Ile Ser Asp Phe Ser Met Ser Tyr
    1010                1015                1020                
Glu Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro Cys Glu
1025                1030                1035                1040
Glu Pro Glu Val Pro Ala Tyr Ser Ile Arg Lys Gly Leu Gln Phe Gly
                1045                1050                1055    
Val Gly Asp Thr Leu Thr Phe Ser Cys Phe Pro Gly Tyr Arg Leu Glu
            1060                1065                1070        
Gly Thr Ala Arg Ile Thr Cys Leu Gly Gly Arg Arg Arg Leu Trp Ser
        1075                1080                1085            
Ser Pro Leu Pro Arg Cys Val Ala Glu Cys Gly Asn Ser Val Thr Gly
    1090                1095                1100                
Thr Gln Gly Thr Leu Leu Ser Pro Asn Phe Pro Val Asn Tyr Asn Asn
1105                1110                1115                1120
Asn His Glu Cys Ile Tyr Ser Ile Gln Thr Gln Pro Gly Lys Gly Ile
                1125                1130                1135    
Gln Leu Lys Ala Arg Ala Phe Glu Leu Ser Glu Gly Asp Val Leu Lys
            1140                1145                1150        
Val Tyr Asp Gly Asn Asn Asn Ser Ala Arg Leu Leu Gly Val Phe Ser
        1155                1160                1165            
His Ser Glu Met Met Gly Val Thr Leu Asn Ser Thr Ser Ser Ser Leu
    1170                1175                1180                
Trp Leu Asp Phe Ile Thr Asp Ala Glu Asn Thr Ser Lys Gly Phe Glu
1185                1190                1195                1200
Leu His Phe Ser Ser Phe Glu Leu Ile Lys Cys Glu Asp Pro Gly Thr
                1205                1210                1215    
Pro Lys Phe Gly Tyr Lys Val His Asp Glu Gly His Phe Ala Gly Ser
            1220                1225                1230        
Ser Val Ser Phe Ser Cys Asp Pro Gly Tyr Ser Leu Arg Gly Ser Glu
        1235                1240                1245            
Glu Leu Leu Cys Leu Ser Gly Glu Arg Arg Thr Trp Asp Arg Pro Leu
    1250                1255                1260                
Pro Thr Cys Val Ala Glu Cys Gly Gly Thr Val Arg Gly Glu Val Ser
1265                1270                1275                1280
Gly Gln Val Leu Ser Pro Gly Tyr Pro Ala Pro Tyr Glu His Asn Leu
                1285                1290                1295    
Asn Cys Ile Trp Thr Ile Glu Ala Glu Ala Gly Cys Thr Ile Gly Leu
            1300                1305                1310        
His Phe Leu Val Phe Asp Thr Glu Glu Val His Asp Val Leu Arg Ile
        1315                1320                1325            
Trp Asp Gly Pro Val Glu Ser Gly Val Leu Leu Lys Glu Leu Ser Gly
    1330                1335                1340                
Pro Ala Leu Pro Lys Asp Leu His Ser Thr Phe Asn Ser Val Val Leu
1345                1350                1355                1360
Gln Phe Ser Thr Asp Phe Phe Thr Ser Lys Gln Gly Phe Ala Ile Gln
                1365                1370                1375    
Phe Ser Val Ser Thr Ala Thr Ser Cys Asn Asp Pro Gly Ile Pro Gln
            1380                1385                1390        
Asn Gly Ser Arg Ser Gly Asp Ser Trp Glu Ala Gly Asp Ser Thr Val
        1395                1400                1405            
Phe Gln Cys Asp Pro Gly Tyr Ala Leu Gln Gly Ser Ala Glu Ile Ser
    1410                1415                1420                
Cys Val Lys Ile Glu Asn Arg Phe Phe Trp Gln Pro Ser Pro Pro Thr
1425                1430                1435                1440
Cys Ile Ala Pro Cys Gly Gly Asp Leu Thr Gly Pro Ser Gly Val Ile
                1445                1450                1455    
Leu Ser Pro Asn Tyr Pro Glu Pro Tyr Pro Pro Gly Lys Glu Cys Asp
            1460                1465                1470        
Trp Lys Val Thr Val Ser Pro Asp Tyr Val Ile Ala Leu Val Phe Asn
        1475                1480                1485            
Ile Phe Asn Leu Glu Pro Gly Tyr Asp Phe Leu His Ile Tyr Asp Gly
    1490                1495                1500                
Arg Asp Ser Leu Ser Pro Leu Ile Gly Ser Phe Tyr Gly Ser Gln Leu
1505                1510                1515                1520
Pro Gly Arg Ile Glu Ser Ser Ser Asn Ser Leu Phe Leu Ala Phe Arg
                1525                1530                1535    
Ser Asp Ala Ser Val Ser Asn Ala Gly Phe Val Ile Asp Tyr Thr Glu
            1540                1545                1550        
Asn Pro Arg Glu Ser Cys Phe Asp Pro Gly Ser Ile Lys Asn Gly Thr
        1555                1560                1565            
Arg Val Gly Ser Asp Leu Lys Leu Gly Ser Ser Val Thr Tyr Tyr Cys
    1570                1575                1580                
His Gly Gly Tyr Glu Val Glu Gly Thr Ser Thr Leu Ser Cys Ile Leu
1585                1590                1595                1600
Gly Pro Asp Gly Lys Pro Val Trp Asn Asn Pro Arg Pro Val Cys Thr
                1605                1610                1615    
Ala Pro Cys Gly Gly Gln Tyr Val Gly Ser Asp Gly Val Val Leu Ser
            1620                1625                1630        
Pro Asn Tyr Pro Gln Asn Tyr Thr Ser Gly Gln Ile Cys Leu Tyr Phe
        1635                1640                1645            
Val Thr Val Pro Lys Asp Tyr Val Val Phe Gly Gln Phe Ala Phe Phe
    1650                1655                1660                
His Thr Ala Leu Asn Asp Val Val Glu Val His Asp Gly His Ser Gln
1665                1670                1675                1680
His Ser Arg Leu Leu Ser Ser Leu Ser Gly Ser His Thr Gly Glu Ser
                1685                1690                1695    
Leu Pro Leu Ala Thr Ser Asn Gln Val Leu Ile Lys Phe Ser Ala Lys
            1700                1705                1710        
Gly Leu Ala Pro Ala Arg Gly Phe His Phe Val Tyr Gln Ala Val Pro
        1715                1720                1725            
Arg Thr Ser Ala Thr Gln Cys Ser Ser Val Pro Glu Pro Arg Tyr Gly
    1730                1735                1740                
Lys Arg Leu Gly Ser Asp Phe Ser Val Gly Ala Ile Val Arg Phe Glu
1745                1750                1755                1760
Cys Asn Ser Gly Tyr Ala Leu Gln Gly Ser Pro Glu Ile Glu Cys Leu
                1765                1770                1775    
Pro Val Pro Gly Ala Leu Ala Gln Trp Asn Val Ser Ala Pro Thr Cys
            1780                1785                1790        
Val Val Pro Cys Gly Gly Asn Leu Thr Glu Arg Arg Gly Thr Ile Leu
        1795                1800                1805            
Ser Pro Gly Phe Pro Glu Pro Tyr Leu Asn Ser Leu Asn Cys Val Trp
    1810                1815                1820                
Lys Ile Val Val Pro Glu Gly Ala Gly Ile Gln Ile Gln Val Val Ser
1825                1830                1835                1840
Phe Val Thr Glu Gln Asn Trp Asp Ser Leu Glu Val Phe Asp Gly Ala
                1845                1850                1855    
Asp Asn Thr Val Thr Met Leu Gly Ser Phe Ser Gly Thr Thr Val Pro
            1860                1865                1870        
Ala Leu Leu Asn Ser Thr Ser Asn Gln Leu Tyr Leu His Phe Tyr Ser
        1875                1880                1885            
Asp Ile Ser Val Ser Ala Ala Gly Phe His Leu Glu Tyr Lys Thr Val
    1890                1895                1900                
Gly Leu Ser Ser Cys Pro Glu Pro Ala Val Pro Ser Asn Gly Val Lys
1905                1910                1915                1920
Thr Gly Glu Arg Tyr Leu Val Asn Asp Val Val Ser Phe Gln Cys Glu
                1925                1930                1935    
Pro Gly Tyr Ala Leu Gln Gly His Ala His Ile Ser Cys Met Pro Gly
            1940                1945                1950        
Thr Val Arg Arg Trp Asn Tyr Pro Pro Pro Leu Cys Ile Ala Gln Cys
        1955                1960                1965            
Gly Gly Thr Val Glu Glu Met Glu Gly Val Ile Leu Ser Pro Gly Phe
    1970                1975                1980                
Pro Gly Asn Tyr Pro Ser Asn Met Asp Cys Ser Trp Lys Ile Ala Leu
1985                1990                1995                2000
Pro Val Gly Phe Gly Ala His Ile Gln Phe Leu Asn Phe Ser Thr Glu
                2005                2010                2015    
Pro Asn His Asp Tyr Ile Glu Ile Arg Asn Gly Pro Tyr Glu Thr Ser
            2020                2025                2030        
Arg Met Met Gly Arg Phe Ser Gly Ser Glu Leu Pro Ser Ser Leu Leu
        2035                2040                2045            
Ser Thr Ser His Glu Thr Thr Val Tyr Phe His Ser Asp His Ser Gln
    2050                2055                2060                
Asn Arg Pro Gly Phe Lys Leu Glu Tyr Gln Asp Leu Thr Tyr Ser His
2065                2070                2075                2080
Gln Ile Ser Ser Phe Leu Arg Gly Phe Asp Leu Ser Glu Leu Glu Arg
                2085                2090                2095    
Thr Asn Ser Thr Pro Pro Val Ala Ala Ser Tyr Val Trp Asp Leu Asp
            2100                2105                2110        
Pro Gly Cys Glu Ala Tyr Glu Leu Gln Glu Cys Pro Asp Pro Glu Pro
        2115                2120                2125            
Phe Ala Asn Gly Ile Val Arg Gly Ala Gly Tyr Asn Val Gly Gln Ser
    2130                2135                2140                
Val Thr Phe Glu Cys Leu Pro Gly Tyr Gln Leu Thr Gly His Pro Val
2145                2150                2155                2160
Leu Thr Cys Gln His Gly Thr Asn Arg Asn Trp Asp His Pro Leu Pro
                2165                2170                2175    
Lys Cys Glu Val Pro Cys Gly Gly Asn Ile Thr Ser Ser Asn Gly Thr
            2180                2185                2190        
Val Tyr Ser Pro Gly Phe Pro Ser Pro Tyr Ser Ser Ser Gln Asp Cys
        2195                2200                2205            
Val Trp Leu Ile Thr Val Pro Ile Gly His Gly Val Arg Leu Asn Leu
    2210                2215                2220                
Ser Leu Leu Gln Thr Glu Pro Ser Gly Asp Phe Ile Thr Ile Trp Asp
2225                2230                2235                2240
Gly Pro Gln Gln Thr Ala Pro Arg Leu Gly Val Phe Thr Arg Ser Met
                2245                2250                2255    
Ala Lys Lys Thr Val Gln Ser Ser Ser Asn Gln Val Leu Leu Lys Phe
            2260                2265                2270        
His Arg Asp Ala Ala Thr Gly Gly Ile Phe Ala Ile Ala Phe Ser Ala
        2275                2280                2285            
Tyr Pro Leu Thr Lys Cys Pro Pro Pro Thr Ile Leu Pro Asn Ala Glu
    2290                2295                2300                
Val Val Thr Glu Asn Glu Glu Phe Asn Ile Gly Asp Ile Val Arg Tyr
2305                2310                2315                2320
Arg Cys Leu Pro Gly Phe Thr Leu Val Gly Asn Glu Ile Leu Thr Cys
                2325                2330                2335    
Lys Leu Gly Thr Tyr Leu Gln Phe Glu Gly Pro Pro Pro Ile Cys Glu
            2340                2345                2350        
Val His Cys Pro Thr Asn Glu Leu Leu Thr Asp Ser Thr Gly Val Ile
        2355                2360                2365            
Leu Ser Gln Ser Tyr Pro Gly Ser Tyr Pro Gln Phe Gln Thr Cys Ser
    2370                2375                2380                
Trp Leu Val Arg Val Glu Pro Asp Tyr Asn Ile Ser Leu Thr Val Glu
2385                2390                2395                2400
Tyr Phe Leu Ser Glu Lys Gln Tyr Asp Glu Phe Glu Ile Phe Asp Gly
                2405                2410                2415    
Pro Ser Gly Gln Ser Pro Leu Leu Lys Ala Leu Ser Gly Asn Tyr Ser
            2420                2425                2430        
Ala Pro Leu Ile Val Thr Ser Ser Ser Asn Ser Val Tyr Leu Arg Trp
        2435                2440                2445            
Ser Ser Asp His Ala Tyr Asn Arg Lys Gly Phe Lys Ile Arg Tyr Ser
    2450                2455                2460                
Ala Pro Tyr Cys Ser Leu Pro Arg Ala Pro Leu His Gly Phe Ile Leu
2465                2470                2475                2480
Gly Gln Thr Ser Thr Gln Pro Gly Gly Ser Ile His Phe Gly Cys Asn
                2485                2490                2495    
Ala Gly Tyr Arg Leu Val Gly His Ser Met Ala Ile Cys Thr Arg His
            2500                2505                2510        
Pro Gln Gly Tyr His Leu Trp Ser Glu Ala Ile Pro Leu Cys Gln Ala
        2515                2520                2525            
Leu Ser Cys Gly Leu Pro Glu Ala Pro Lys Asn Gly Met Val Phe Gly
    2530                2535                2540                
Lys Glu Tyr Thr Val Gly Thr Lys Ala Met Tyr Ser Cys Ser Glu Gly
2545                2550                2555                2560
Tyr His Leu Gln Ala Gly Ala Glu Ala Thr Ala Glu Cys Leu Asp Thr
                2565                2570                2575    
Gly Leu Trp Ser Asn Arg Asn Val Pro Pro Gln Cys Val Pro Val Thr
            2580                2585                2590        
Cys Pro Asp Val Ser Ser Ile Ser Val Glu His Gly Arg Trp Arg Leu
        2595                2600                2605            
Ile Phe Glu Thr Gln Tyr Gln Phe Gln Ala Gln Leu Met Leu Ile Cys
    2610                2615                2620                
Asp Pro Gly Tyr Tyr Tyr Thr Gly Gln Arg Val Ile Arg Cys Gln Ala
2625                2630                2635                2640
Asn Gly Lys Trp Ser Leu Gly Asp Ser Thr Pro Thr Cys Arg Ile Ile
                2645                2650                2655    
Ser Cys Gly Glu Leu Pro Ile Pro Pro Asn Gly His Arg Ile Gly Thr
            2660                2665                2670        
Leu Ser Val Tyr Gly Ala Thr Ala Ile Phe Ser Cys Asn Ser Gly Tyr
        2675                2680                2685            
Thr Leu Val Gly Ser Arg Val Arg Glu Cys Met Ala Asn Gly Leu Trp
    2690                2695                2700                
Ser Gly Ser Glu Val Arg Cys Leu Ala Gly His Cys Gly Thr Pro Glu
2705                2710                2715                2720
Pro Ile Val Asn Gly His Ile Asn Gly Glu Asn Tyr Ser Tyr Arg Gly
                2725                2730                2735    
Ser Val Val Tyr Gln Cys Asn Ala Gly Phe Arg Leu Ile Gly Met Ser
            2740                2745                2750        
Val Arg Ile Cys Gln Gln Asp His His Trp Ser Gly Lys Thr Pro Phe
        2755                2760                2765            
Cys Val Leu Val Ser Cys Gly His Pro Gly Ser Pro Pro His Ser Gln
    2770                2775                2780                
Met Ser Gly Asp Ser Tyr Thr Val Gly Ala Val Val Arg Tyr Ser Cys
2785                2790                2795                2800
Ile Gly Lys Arg Thr Leu Val Gly Asn Ser Thr Arg Met Cys Gly Leu
                2805                2810                2815    
Asp Gly His Trp Thr Gly Ser Leu Pro His Cys Ser Gly Thr Ser Val
            2820                2825                2830        
Gly Val Cys Gly Asp Pro Gly Ile Pro Ala His Gly Ile Arg Leu Gly
        2835                2840                2845            
Asp Ser Phe Asp Pro Gly Thr Val Met Arg Phe Ser Cys Glu Ala Gly
    2850                2855                2860                
His Val Leu Arg Gly Ser Ser Glu Arg Thr Cys Gln Ala Asn Gly Ser
2865                2870                2875                2880
Trp Ser Gly Ser Gln Pro Glu Cys Gly Val Ile Ser Cys Gly Asn Pro
                2885                2890                2895    
Gly Thr Pro Ser Asn Ala Arg Val Val Phe Ser Asp Gly Leu Val Phe
            2900                2905                2910        
Ser Ser Ser Ile Val Tyr Glu Cys Arg Glu Gly Tyr Tyr Ala Thr Gly
        2915                2920                2925            
Leu Leu Ser Arg His Cys Ser Val Asn Gly Thr Trp Thr Gly Ser Asp
    2930                2935                2940                
Pro Glu Cys Leu Val Ile Asn Cys Gly Asp Pro Gly Ile Pro Ala Asn
2945                2950                2955                2960
Gly Leu Arg Leu Gly Asn Asp Phe Arg Tyr Asn Lys Thr Val Thr Tyr
                2965                2970                2975    
Gln Cys Val Pro Gly Tyr Met Met Glu Ser His Arg Val Ser Val Leu
            2980                2985                2990        
Ser Cys Thr Lys Asp Arg Thr Trp Asn Gly Thr Lys Pro Val Cys Lys
        2995                3000                3005            
Ala Leu Met Cys Lys Pro Pro Pro Leu Ile Pro Asn Gly Lys Val Val
    3010                3015                3020                
Gly Ser Asp Phe Met Trp Gly Ser Ser Val Thr Tyr Ala Cys Leu Glu
3025                3030                3035                3040
Gly Tyr Gln Leu Ser Leu Pro Ala Val Phe Thr Cys Glu Gly Asn Gly
                3045                3050                3055    
Ser Trp Thr Gly Glu Leu Pro Gln Cys Phe Pro Val Phe Cys Gly Asp
            3060                3065                3070        
Pro Gly Val Pro Ser Arg Gly Arg Arg Glu Asp Arg Gly Phe Ser Tyr
        3075                3080                3085            
Arg Ser Ser Val Ser Phe Ser Cys His Pro Pro Leu Val Leu Val Gly
    3090                3095                3100                
Ser Pro Arg Arg Phe Cys Gln Ser Asp Gly Thr Trp Ser Gly Thr Gln
3105                3110                3115                3120
Pro Ser Cys Ile Asp Pro Thr Leu Thr Thr Cys Ala Asp Pro Gly Val
                3125                3130                3135    
Pro Gln Phe Gly Ile Gln Asn Asn Ser Gln Gly Tyr Gln Val Gly Ser
            3140                3145                3150        
Thr Val Leu Phe Arg Cys Gln Lys Gly Tyr Leu Leu Gln Gly Ser Thr
        3155                3160                3165            
Thr Arg Thr Cys Leu Pro Asn Leu Thr Trp Ser Gly Thr Pro Pro Asp
    3170                3175                3180                
Cys Val Pro His His Cys Arg Gln Pro Glu Thr Pro Thr His Ala Asn
3185                3190                3195                3200
Val Gly Ala Leu Asp Leu Pro Ser Met Gly Tyr Thr Leu Ile Tyr Ser
                3205                3210                3215    
Cys Gln Glu Gly Phe Ser Leu Lys Gly Gly Ser Glu His Arg Thr Cys
            3220                3225                3230        
Lys Ala Asp Gly Ser Trp Thr Gly Lys Pro Pro Ile Cys Leu Glu Val
        3235                3240                3245            
Arg Pro Asn Gly Arg Pro Ile Asn Thr Ala Arg Glu Pro Pro Leu Thr
    3250                3255                3260                
Gln Ala Leu Ile Pro Gly Asp Val Phe Ala Lys Asn Ser Leu Trp Lys
3265                3270                3275                3280
Gly Ala Tyr Glu Tyr Gln Gly Lys Lys Gln Pro Ala Met Leu Arg Val
                3285                3290                3295    
Thr Gly Phe Gln Val Ala Asn Ser Lys Val Asn Ala Thr Met Ile Asp
            3300                3305                3310        
His Ser Gly Val Glu Leu His Leu Ala Gly Thr Tyr Lys Lys Glu Asp
        3315                3320                3325            
Phe His Leu Leu Leu Gln Val Tyr Gln Ile Thr Gly Pro Val Glu Ile
    3330                3335                3340                
Phe Met Asn Lys Phe Lys Asp Asp His Trp Ala Leu Asp Gly His Val
3345                3350                3355                3360
Ser Ser Glu Ser Ser Gly Ala Thr Phe Ile Tyr Gln Gly Ser Val Lys
                3365                3370                3375    
Gly Gln Gly Phe Gly Gln Phe Gly Phe Gln Arg Leu Asp Leu Arg Leu
            3380                3385                3390        
Leu Glu Ser Asp Pro Glu Ser Ile Gly Arg His Phe Ala Ser Asn Ser
        3395                3400                3405            
Ser Ser Val Ala Ala Ala Ile Leu Val Pro Phe Ile Ala Leu Ile Ile
    3410                3415                3420                
Ala Gly Phe Val Leu Tyr Leu Tyr Lys His Arg Arg Arg Pro Lys Val
3425                3430                3435                3440
Pro Phe Asn Gly Tyr Ala Gly His Glu Asn Thr Asn Val Arg Ala Thr
                3445                3450                3455    
Phe Glu Asn Pro Met Tyr Asp Arg Asn Ile Gln Pro Thr Asp Ile Met
            3460                3465                3470        
Ala Ser Glu Ala Glu Phe Thr Val Ser Thr Val Cys Thr Ala Val
        3475                3480                3485        


<210> 9294
<211> 385
<212> PRT
<213> Homo sapiens

<400> 9294
Met Trp Gly Arg Leu Leu Leu Trp Pro Leu Val Leu Gly Phe Ser Leu
 1               5                  10                  15      
Ser Gly Gly Thr Gln Thr Pro Ser Val Tyr Asp Glu Ser Gly Ser Thr
            20                  25                  30          
Gly Gly Gly Asp Asp Ser Thr Pro Ser Ile Leu Pro Ala Pro Arg Gly
        35                  40                  45              
Tyr Pro Gly Gln Val Cys Ala Asn Asp Ser Asp Thr Leu Glu Leu Pro
    50                  55                  60                  
Asp Ser Ser Arg Ala Leu Leu Leu Gly Trp Val Pro Thr Arg Leu Val
65                  70                  75                  80  
Pro Ala Leu Tyr Gly Leu Val Leu Val Val Gly Leu Pro Ala Asn Gly
                85                  90                  95      
Leu Ala Leu Trp Val Leu Ala Thr Gln Ala Pro Arg Leu Pro Ser Thr
            100                 105                 110         
Met Leu Leu Met Asn Leu Ala Thr Ala Asp Leu Leu Leu Ala Leu Ala
        115                 120                 125             
Leu Pro Pro Arg Ile Ala Tyr His Leu Arg Gly Gln Arg Trp Pro Phe
    130                 135                 140                 
Gly Glu Ala Ala Cys Arg Leu Ala Thr Ala Ala Leu Tyr Gly His Met
145                 150                 155                 160 
Tyr Gly Ser Val Leu Leu Leu Ala Ala Val Ser Leu Asp Arg Tyr Leu
                165                 170                 175     
Ala Leu Val His Pro Leu Arg Ala Arg Ala Leu Arg Gly Arg Arg Leu
            180                 185                 190         
Ala Leu Gly Leu Cys Met Ala Ala Trp Leu Met Ala Ala Ala Leu Ala
        195                 200                 205             
Leu Pro Leu Thr Leu Gln Arg Gln Thr Phe Arg Leu Ala Arg Ser Asp
    210                 215                 220                 
Arg Val Leu Cys His Asp Ala Leu Pro Leu Asp Ala Gln Ala Ser His
225                 230                 235                 240 
Trp Gln Pro Ala Phe Thr Cys Leu Ala Leu Leu Gly Cys Phe Leu Pro
                245                 250                 255     
Leu Leu Ala Met Leu Leu Cys Tyr Gly Ala Thr Leu His Thr Leu Ala
            260                 265                 270         
Ala Ser Gly Arg Arg Tyr Gly His Ala Leu Arg Leu Thr Ala Val Val
        275                 280                 285             
Leu Ala Ser Ala Val Ala Phe Phe Val Pro Ser Asn Leu Leu Leu Leu
    290                 295                 300                 
Leu His Tyr Ser Asp Pro Ser Pro Ser Ala Trp Gly Asn Leu Tyr Gly
305                 310                 315                 320 
Ala Tyr Val Pro Ser Leu Ala Leu Ser Thr Leu Asn Ser Cys Val Asp
                325                 330                 335     
Pro Phe Ile Tyr Tyr Tyr Val Ser Ala Glu Phe Arg Asp Lys Val Arg
            340                 345                 350         
Ala Gly Leu Phe Gln Arg Ser Pro Gly Asp Thr Val Ala Ser Lys Ala
        355                 360                 365             
Ser Ala Glu Gly Gly Ser Arg Gly Met Gly Thr His Ser Ser Leu Leu
    370                 375                 380                 
Gln
385 


<210> 9295
<211> 1010
<212> PRT
<213> Homo sapiens

<400> 9295
Ala Glu Gly Arg Pro Ala Lys Pro Ser Lys Thr Ala Ala Arg Glu Lys
 1               5                  10                  15      
Thr Glu Gly Ala Val Ala Ala Val Gly Gly Gly Pro Ser Ser Phe Arg
            20                  25                  30          
Cys Cys Tyr Gly Cys Cys His Glu Ala Arg Leu Gly Arg Thr Ser Leu
        35                  40                  45              
Pro Arg Gly Val Ile Met Leu Thr Glu Ala Ser Leu Ser Ile Trp Gly
    50                  55                  60                  
Trp Gly Ser Leu Gly Ile Val Leu Phe Leu Ile Thr Phe Gly Pro Phe
65                  70                  75                  80  
Val Ile Phe Tyr Leu Thr Phe Tyr Ile Leu Cys Phe Val Gly Gly Gly
                85                  90                  95      
Leu Val Val Thr Leu Leu Phe Gly Lys Thr Asn Ser Glu Lys Tyr Leu
            100                 105                 110         
Glu Gln Cys Glu His Ser Phe Leu Pro Pro Thr Ser Pro Gly Val Pro
        115                 120                 125             
Lys Cys Leu Glu Glu Met Lys Arg Glu Ala Arg Thr Ile Lys Ile Asp
    130                 135                 140                 
Arg Arg Leu Thr Gly Ala Asn Ile Ile Asp Glu Pro Leu Gln Gln Val
145                 150                 155                 160 
Ile Gln Phe Ser Leu Arg Asp Tyr Val Gln Tyr Trp Tyr Tyr Thr Leu
                165                 170                 175     
Ser Asp Asp Glu Ser Phe Leu Leu Glu Ile Arg Gln Thr Leu Gln Asn
            180                 185                 190         
Ala Leu Ile Gln Phe Ala Thr Arg Ser Lys Glu Ile Asp Trp Gln Pro
        195                 200                 205             
Tyr Phe Thr Thr Arg Ile Val Asp Asp Phe Gly Thr His Leu Arg Val
    210                 215                 220                 
Phe Arg Lys Ala Gln Gln Lys Ile Thr Glu Lys Asp Asp Gln Val Lys
225                 230                 235                 240 
Gly Thr Ala Glu Asp Leu Val Asp Thr Phe Phe Glu Val Glu Val Glu
                245                 250                 255     
Met Glu Lys Glu Val Cys Arg Asp Leu Val Cys Thr Ser Pro Lys Asp
            260                 265                 270         
Glu Glu Gly Phe Leu Arg Asp Leu Cys Glu Val Leu Leu Tyr Leu Leu
        275                 280                 285             
Leu Pro Pro Gly Asp Phe Gln Asn Lys Ile Met Arg Tyr Phe Val Arg
    290                 295                 300                 
Glu Ile Leu Ala Arg Gly Ile Leu Leu Pro Leu Ile Asn Gln Leu Ser
305                 310                 315                 320 
Asp Pro Asp Tyr Ile Asn Gln Tyr Val Ile Trp Met Ile Arg Asp Ser
                325                 330                 335     
Asn Cys Asn Tyr Glu Ala Phe Met Asn Ile Ile Lys Leu Ser Asp Asn
            340                 345                 350         
Ile Gly Glu Leu Glu Ala Val Arg Asp Lys Ala Ala Glu Glu Leu Gln
        355                 360                 365             
Tyr Leu Arg Ser Leu Asp Thr Ala Gly Asp Asp Ile Asn Thr Ile Lys
    370                 375                 380                 
Asn Gln Ile Asn Ser Leu Leu Phe Val Lys Lys Val Cys Asp Ser Arg
385                 390                 395                 400 
Ile Gln Arg Leu Gln Ser Gly Lys Glu Ile Asn Thr Val Lys Leu Ala
                405                 410                 415     
Ala Asn Phe Gly Lys Leu Cys Thr Val Pro Leu Asp Ser Ile Leu Val
            420                 425                 430         
Asp Asn Val Ala Leu Gln Phe Phe Met Asp Tyr Met Gln Gln Thr Gly
        435                 440                 445             
Gly Gln Ala His Leu Phe Phe Trp Met Thr Val Glu Gly Tyr Arg Val
    450                 455                 460                 
Thr Ala Gln Gln Gln Leu Glu Val Leu Leu Ser Arg Gln Arg Asp Gly
465                 470                 475                 480 
Lys His Gln Thr Asn Gln Thr Lys Gly Leu Leu Arg Ala Ala Ala Val
                485                 490                 495     
Gly Ile Tyr Glu Gln Tyr Leu Ser Glu Lys Ala Ser Pro Arg Val Thr
            500                 505                 510         
Val Asp Asp Tyr Leu Val Ala Lys Leu Ala Asp Thr Leu Asn His Glu
        515                 520                 525             
Asp Pro Thr Pro Glu Ile Phe Asp Asp Ile Gln Arg Lys Val Tyr Glu
    530                 535                 540                 
Leu Met Leu Arg Asp Glu Arg Phe Tyr Pro Ser Phe Arg Gln Asn Ala
545                 550                 555                 560 
Leu Tyr Val Arg Met Leu Ala Glu Leu Asp Met Leu Lys Asp Pro Ser
                565                 570                 575     
Phe Arg Gly Ser Asp Asp Gly Asp Gly Glu Ser Phe Asn Gly Ser Pro
            580                 585                 590         
Thr Gly Ser Ile Asn Leu Ser Leu Asp Asp Leu Ser Asn Val Ser Ser
        595                 600                 605             
Asp Asp Ser Val Gln Leu His Ala Tyr Ile Ser Asp Thr Gly Val Cys
    610                 615                 620                 
Asn Asp His Gly Lys Thr Tyr Ala Leu Tyr Ala Ile Thr Val His Arg
625                 630                 635                 640 
Arg Asn Leu Asn Ser Glu Glu Met Trp Lys Thr Tyr Arg Arg Tyr Ser
                645                 650                 655     
Asp Phe His Asp Phe His Met Arg Ile Thr Glu Gln Phe Glu Ser Leu
            660                 665                 670         
Ser Ser Ile Leu Lys Leu Pro Gly Lys Lys Thr Phe Asn Asn Met Asp
        675                 680                 685             
Arg Asp Phe Leu Glu Lys Arg Lys Lys Asp Leu Asn Ala Tyr Leu Gln
    690                 695                 700                 
Leu Leu Leu Ala Pro Glu Met Met Lys Ala Ser Pro Ala Leu Ala His
705                 710                 715                 720 
Tyr Val Tyr Asp Phe Leu Glu Asn Lys Ala Tyr Ser Lys Gly Lys Gly
                725                 730                 735     
Asp Phe Ala Arg Lys Met Asp Thr Phe Val Asn Pro Leu Arg Asn Ser
            740                 745                 750         
Met Arg Asn Val Ser Asn Ala Val Lys Ser Leu Pro Asp Ser Leu Ala
        755                 760                 765             
Glu Gly Met Thr Lys Met Ser Asp Asn Met Gly Lys Met Ser Glu Arg
    770                 775                 780                 
Leu Gly Gln Asp Ile Lys Gln Ser Phe Phe Lys Val Pro Pro Leu Ile
785                 790                 795                 800 
Pro Lys Thr Asp Ser Asp Pro Glu His Arg Arg Val Ser Ala Gln Leu
                805                 810                 815     
Asp Asp Asn Val Asp Asp Asn Ile Pro Leu Arg Val Met Leu Leu Leu
            820                 825                 830         
Met Asp Glu Val Phe Asp Leu Lys Glu Arg Asn Gln Trp Leu Arg Arg
        835                 840                 845             
Asn Ile Lys Asn Leu Leu Gln Gln Leu Ile Arg Ala Thr Tyr Gly Asp
    850                 855                 860                 
Thr Ile Asn Arg Lys Ile Val Asp His Val Asp Trp Met Thr Ser Pro
865                 870                 875                 880 
Glu Gln Val Ala Asp Ser Val Lys Arg Phe Arg Asp Ala Phe Trp Pro
                885                 890                 895     
Asn Gly Ile Leu Ala Glu Ala Val Pro Cys Arg Asp Lys Ser Ile Arg
            900                 905                 910         
Met Arg Thr Arg Val Ala Gly Lys Thr Lys Leu Leu Ala Ile Met Pro
        915                 920                 925             
Asp Glu Leu Lys His Ile Ile Gly Ala Glu Thr Thr Arg Lys Gly Ile
    930                 935                 940                 
Leu Arg Val Phe Glu Met Phe Gln His Asn Gln Leu Asn Arg Arg Met
945                 950                 955                 960 
Val Tyr Val Phe Leu Glu Gly Phe Leu Glu Thr Leu Phe Pro Gln Tyr
                965                 970                 975     
Lys Phe Arg Glu Leu Phe Asn Lys Leu His Ser Arg Ser Lys Gln Met
            980                 985                 990         
Gln Lys Tyr Lys Gln Lys Leu Gln Thr Thr Gln Ala Pro Ser Leu Gln
        995                 1000                1005            
Lys Arg
    1010


<210> 9296
<211> 968
<212> PRT
<213> Homo sapiens

<400> 9296
Met Leu Thr Glu Ala Ser Leu Ser Ile Trp Gly Trp Gly Ser Leu Gly
 1               5                  10                  15      
Ile Val Leu Phe Leu Ile Thr Phe Gly Pro Phe Val Ile Phe Tyr Leu
            20                  25                  30          
Thr Phe Tyr Ile Leu Cys Phe Val Gly Gly Gly Leu Val Val Thr Leu
        35                  40                  45              
Leu Phe Gly Lys Thr Asn Ser Glu Lys Tyr Leu Glu Gln Cys Glu His
    50                  55                  60                  
Ser Phe Leu Pro Pro Thr Ser Pro Gly Val Pro Lys Cys Leu Glu Glu
65                  70                  75                  80  
Met Lys Arg Glu Ala Arg Thr Ile Lys Ile Asp Arg Arg Leu Thr Gly
                85                  90                  95      
Ala Asn Ile Ile Asp Glu Pro Leu Gln Gln Val Ile Gln Phe Ser Leu
            100                 105                 110         
Arg Asp Tyr Val Gln Tyr Trp Tyr Tyr Thr Leu Ser Asp Asp Glu Ser
        115                 120                 125             
Phe Leu Leu Glu Ile Arg Gln Thr Leu Gln Asn Ala Leu Ile Gln Phe
    130                 135                 140                 
Ala Thr Arg Ser Lys Glu Ile Asp Trp Gln Pro Tyr Phe Thr Thr Arg
145                 150                 155                 160 
Ile Val Asp Asp Phe Gly Thr His Leu Arg Val Phe Arg Lys Ala Gln
                165                 170                 175     
Gln Lys Ile Thr Glu Lys Asp Asp Gln Val Lys Gly Thr Ala Glu Asp
            180                 185                 190         
Leu Val Asp Thr Phe Phe Glu Val Glu Val Glu Met Glu Lys Glu Val
        195                 200                 205             
Cys Arg Asp Leu Val Cys Thr Ser Pro Lys Asp Glu Glu Gly Phe Leu
    210                 215                 220                 
Arg Asp Leu Cys Glu Val Leu Leu Tyr Leu Leu Leu Pro Pro Gly Asp
225                 230                 235                 240 
Phe Gln Asn Lys Ile Met Arg Tyr Phe Val Arg Glu Ile Leu Ala Arg
                245                 250                 255     
Gly Ile Leu Leu Pro Leu Ile Asn Gln Leu Ser Asp Pro Asp Tyr Ile
            260                 265                 270         
Asn Gln Tyr Val Ile Trp Met Ile Arg Asp Ser Asn Cys Asn Tyr Glu
        275                 280                 285             
Ala Phe Met Asn Ile Ile Lys Leu Ser Asp Asn Ile Gly Glu Leu Glu
    290                 295                 300                 
Ala Val Arg Asp Lys Ala Ala Glu Glu Leu Gln Tyr Leu Arg Ser Leu
305                 310                 315                 320 
Asp Thr Ala Gly Asp Asp Ile Asn Thr Ile Lys Asn Gln Ile Asn Ser
                325                 330                 335     
Leu Leu Phe Val Lys Lys Val Cys Asp Ser Arg Ile Gln Arg Leu Gln
            340                 345                 350         
Ser Gly Lys Glu Ile Asn Thr Val Lys Leu Ala Ala Asn Phe Gly Lys
        355                 360                 365             
Leu Cys Thr Val Pro Leu Asp Ser Ile Leu Val Asp Asn Val Ala Leu
    370                 375                 380                 
Gln Phe Phe Met Asp Tyr Met Gln Gln Thr Gly Gly Gln Ala His Leu
385                 390                 395                 400 
Phe Phe Trp Met Thr Val Glu Gly Tyr Arg Val Thr Ala Gln Gln Gln
                405                 410                 415     
Leu Glu Val Leu Leu Ser Arg Gln Arg Asp Gly Lys His Gln Thr Asn
            420                 425                 430         
Gln Thr Lys Gly Leu Leu Arg Ala Ala Ala Val Gly Ile Tyr Glu Gln
        435                 440                 445             
Tyr Leu Ser Glu Lys Ala Ser Pro Arg Val Thr Val Asp Asp Tyr Leu
    450                 455                 460                 
Val Ala Lys Leu Ala Asp Thr Leu Asn His Glu Asp Pro Thr Pro Glu
465                 470                 475                 480 
Ile Phe Asp Asp Ile Gln Arg Lys Val Tyr Glu Leu Met Leu Arg Asp
                485                 490                 495     
Glu Arg Phe Tyr Pro Ser Phe Arg Gln Asn Ala Leu Tyr Val Arg Met
            500                 505                 510         
Leu Ala Glu Leu Asp Met Leu Lys Asp Pro Ser Phe Arg Gly Ser Asp
        515                 520                 525             
Asp Gly Asp Gly Glu Ser Phe Asn Gly Ser Pro Thr Gly Ser Ile Asn
    530                 535                 540                 
Leu Ser Leu Asp Asp Leu Ser Asn Val Ser Ser Asp Asp Ser Val Gln
545                 550                 555                 560 
Leu His Ala Tyr Ile Ser Asp Thr Val Tyr Ala Asp Tyr Asp Pro Tyr
                565                 570                 575     
Ala Val Ala Gly Val Cys Asn Asp His Gly Lys Thr Tyr Ala Leu Tyr
            580                 585                 590         
Ala Ile Thr Val His Arg Arg Asn Leu Asn Ser Glu Glu Met Trp Lys
        595                 600                 605             
Thr Tyr Arg Arg Tyr Ser Asp Phe His Asp Phe His Met Arg Ile Thr
    610                 615                 620                 
Glu Gln Phe Glu Ser Leu Ser Ser Ile Leu Lys Leu Pro Gly Lys Lys
625                 630                 635                 640 
Thr Phe Asn Asn Met Asp Arg Asp Phe Leu Glu Lys Arg Lys Lys Asp
                645                 650                 655     
Leu Asn Ala Tyr Leu Gln Leu Leu Leu Ala Pro Glu Met Met Lys Ala
            660                 665                 670         
Ser Pro Ala Leu Ala His Tyr Val Tyr Asp Phe Leu Glu Asn Lys Ala
        675                 680                 685             
Tyr Ser Lys Gly Lys Gly Asp Phe Ala Arg Lys Met Asp Thr Phe Val
    690                 695                 700                 
Asn Pro Leu Arg Asn Ser Met Arg Asn Val Ser Asn Ala Val Lys Ser
705                 710                 715                 720 
Leu Pro Asp Ser Leu Ala Glu Gly Met Thr Lys Met Ser Asp Asn Met
                725                 730                 735     
Gly Lys Met Ser Glu Arg Leu Gly Gln Asp Ile Lys Gln Ser Phe Phe
            740                 745                 750         
Lys Val Pro Pro Leu Ile Pro Lys Thr Asp Ser Asp Pro Glu His Arg
        755                 760                 765             
Arg Val Ser Ala Gln Leu Asp Asp Asn Val Asp Asp Asn Ile Pro Leu
    770                 775                 780                 
Arg Val Met Leu Leu Leu Met Asp Glu Val Phe Asp Leu Lys Glu Arg
785                 790                 795                 800 
Asn Gln Trp Leu Arg Arg Asn Ile Lys Asn Leu Leu Gln Gln Leu Ile
                805                 810                 815     
Arg Ala Thr Tyr Gly Asp Thr Ile Asn Arg Lys Ile Val Asp His Val
            820                 825                 830         
Asp Trp Met Thr Ser Pro Glu Gln Val Ala Asp Ser Val Lys Arg Phe
        835                 840                 845             
Arg Asp Ala Phe Trp Pro Asn Gly Ile Leu Ala Glu Ala Val Pro Cys
    850                 855                 860                 
Arg Asp Lys Ser Ile Arg Met Arg Thr Arg Val Ala Gly Lys Thr Lys
865                 870                 875                 880 
Leu Leu Ala Ile Met Pro Asp Glu Leu Lys His Ile Ile Gly Ala Glu
                885                 890                 895     
Thr Thr Arg Lys Gly Ile Leu Arg Val Phe Glu Met Phe Gln His Asn
            900                 905                 910         
Gln Leu Asn Arg Arg Met Val Tyr Val Phe Leu Glu Gly Phe Leu Glu
        915                 920                 925             
Thr Leu Phe Pro Gln Tyr Lys Phe Arg Glu Leu Phe Asn Lys Leu His
    930                 935                 940                 
Ser Arg Ser Lys Gln Met Gln Lys Tyr Lys Gln Lys Leu Gln Thr Thr
945                 950                 955                 960 
Gln Ala Pro Ser Leu Gln Lys Arg
                965             


<210> 9297
<211> 1294
<212> PRT
<213> Homo sapiens

<400> 9297
Met Ala Ser Pro Pro His Gln Gln Leu Leu His His His Ser Thr Glu
 1               5                  10                  15      
Val Ser Cys Asp Ser Ser Gly Asp Ser Asn Ser Val Arg Val Lys Ile
            20                  25                  30          
Asn Pro Lys Gln Leu Ser Ser Asn Ser His Pro Lys His Cys Lys Tyr
        35                  40                  45              
Ser Ile Ser Ser Ser Cys Ser Ser Ser Gly Asp Ser Gly Gly Val Pro
    50                  55                  60                  
Arg Arg Val Gly Gly Gly Gly Arg Leu Arg Arg Gln Lys Lys Leu Pro
65                  70                  75                  80  
Gln Leu Phe Glu Arg Ala Ser Ser Arg Trp Trp Asp Pro Lys Phe Asp
                85                  90                  95      
Ser Val Asn Leu Glu Glu Ala Cys Leu Glu Arg Cys Phe Pro Gln Thr
            100                 105                 110         
Gln Arg Arg Phe Arg Tyr Ala Leu Phe Tyr Ile Gly Phe Ala Cys Leu
        115                 120                 125             
Leu Trp Ser Ile Tyr Phe Ala Val His Met Arg Ser Arg Leu Ile Val
    130                 135                 140                 
Met Val Ala Pro Ala Leu Cys Phe Leu Leu Val Cys Val Gly Phe Phe
145                 150                 155                 160 
Leu Phe Thr Phe Thr Lys Leu Tyr Ala Arg His Tyr Ala Trp Thr Ser
                165                 170                 175     
Leu Ala Leu Thr Leu Leu Val Phe Ala Leu Thr Leu Ala Ala Gln Phe
            180                 185                 190         
Gln Val Leu Thr Pro Val Ser Gly Arg Gly Asp Ser Ser Asn Leu Thr
        195                 200                 205             
Ala Thr Ala Arg Pro Thr Asp Thr Cys Leu Ser Gln Val Gly Ser Phe
    210                 215                 220                 
Ser Met Cys Ile Glu Val Leu Phe Leu Leu Tyr Thr Val Met His Leu
225                 230                 235                 240 
Pro Leu Tyr Leu Ser Leu Cys Leu Gly Val Ala Tyr Ser Val Leu Phe
                245                 250                 255     
Glu Thr Phe Gly Tyr His Phe Arg Asp Glu Ala Cys Phe Pro Ser Pro
            260                 265                 270         
Gly Ala Gly Ala Leu His Trp Glu Leu Leu Ser Arg Gly Leu Leu His
        275                 280                 285             
Gly Cys Ile His Ala Ile Gly Val His Leu Phe Val Met Ser Gln Val
    290                 295                 300                 
Arg Ser Arg Ser Thr Phe Leu Lys Val Gly Gln Ser Ile Met His Gly
305                 310                 315                 320 
Lys Asp Leu Glu Val Glu Lys Ala Leu Lys Glu Arg Met Ile His Ser
                325                 330                 335     
Val Met Pro Arg Ile Ile Ala Asp Asp Leu Met Lys Gln Gly Asp Glu
            340                 345                 350         
Glu Ser Glu Asn Ser Val Lys Arg His Ala Thr Ser Ser Pro Lys Asn
        355                 360                 365             
Arg Lys Lys Lys Ser Ser Ile Gln Lys Ala Pro Ile Ala Phe Arg Pro
    370                 375                 380                 
Phe Lys Met Gln Gln Ile Glu Glu Val Ser Ile Leu Phe Ala Asp Ile
385                 390                 395                 400 
Val Gly Phe Thr Lys Met Ser Ala Asn Lys Ser Ala His Ala Leu Val
                405                 410                 415     
Gly Leu Leu Asn Asp Leu Phe Gly Arg Phe Asp Arg Leu Cys Glu Glu
            420                 425                 430         
Thr Lys Cys Glu Lys Ile Ser Thr Leu Gly Asp Cys Tyr Tyr Cys Val
        435                 440                 445             
Ala Gly Cys Pro Glu Pro Arg Ala Asp His Ala Tyr Cys Cys Ile Glu
    450                 455                 460                 
Met Gly Leu Gly Met Ile Lys Ala Ile Glu Gln Phe Cys Gln Glu Lys
465                 470                 475                 480 
Lys Glu Met Val Asn Met Arg Val Gly Val His Thr Gly Thr Val Leu
                485                 490                 495     
Cys Gly Ile Leu Gly Met Arg Arg Phe Lys Phe Asp Val Trp Ser Asn
            500                 505                 510         
Asp Val Asn Leu Ala Asn Leu Met Glu Gln Leu Gly Val Ala Gly Lys
        515                 520                 525             
Val His Ile Ser Glu Ala Thr Ala Lys Tyr Leu Asp Asp Arg Tyr Glu
    530                 535                 540                 
Met Glu Asp Gly Lys Val Ile Glu Arg Leu Gly Gln Ser Val Val Ala
545                 550                 555                 560 
Asp Gln Leu Lys Gly Leu Lys Thr Tyr Leu Ile Ser Gly Gln Arg Ala
                565                 570                 575     
Lys Glu Ser Arg Cys Ser Cys Ala Glu Ala Leu Leu Ser Gly Phe Glu
            580                 585                 590         
Val Ile Asp Gly Ser Gln Val Ser Ser Gly Pro Arg Gly Gln Gly Thr
        595                 600                 605             
Ala Ser Ser Gly Asn Val Ser Asp Leu Ala Gln Thr Val Lys Thr Phe
    610                 615                 620                 
Asp Asn Leu Lys Thr Cys Pro Ser Cys Gly Ile Thr Phe Ala Pro Lys
625                 630                 635                 640 
Ser Glu Ala Gly Ala Glu Gly Gly Ala Pro Gln Asn Gly Cys Gln Asp
                645                 650                 655     
Glu His Lys Asn Ser Thr Lys Ala Ser Gly Gly Pro Asn Pro Lys Thr
            660                 665                 670         
Gln Asn Gly Leu Leu Ser Pro Pro Gln Glu Glu Lys Leu Thr Asn Ser
        675                 680                 685             
Gln Thr Ser Leu Cys Glu Ile Leu Gln Glu Lys Gly Arg Trp Ala Gly
    690                 695                 700                 
Val Ser Leu Asp Gln Ser Ala Leu Leu Pro Leu Arg Phe Lys Asn Ile
705                 710                 715                 720 
Arg Glu Lys Thr Asp Ala His Phe Val Asp Val Ile Lys Glu Asp Ser
                725                 730                 735     
Leu Met Lys Asp Tyr Phe Phe Lys Pro Pro Ile Asn Gln Phe Ser Leu
            740                 745                 750         
Asn Phe Leu Asp Gln Glu Leu Glu Arg Ser Tyr Arg Thr Ser Tyr Gln
        755                 760                 765             
Glu Glu Val Ile Lys Asn Ser Pro Val Lys Thr Phe Ala Ser Pro Thr
    770                 775                 780                 
Phe Ser Ser Leu Leu Asp Val Phe Leu Ser Thr Thr Val Phe Leu Thr
785                 790                 795                 800 
Leu Ser Thr Thr Cys Phe Leu Lys Tyr Glu Ala Ala Thr Val Pro Pro
                805                 810                 815     
Pro Pro Ala Ala Leu Ala Val Phe Ser Ala Ala Leu Leu Leu Glu Val
            820                 825                 830         
Leu Ser Leu Ala Val Ser Ile Arg Met Val Phe Phe Leu Glu Asp Val
        835                 840                 845             
Met Ala Cys Thr Lys Arg Leu Leu Glu Trp Ile Ala Gly Trp Leu Pro
    850                 855                 860                 
Arg His Cys Ile Gly Ala Ile Leu Val Ser Leu Pro Ala Leu Ala Val
865                 870                 875                 880 
Tyr Ser His Val Thr Ser Glu Tyr Glu Thr Asn Ile His Phe Pro Val
                885                 890                 895     
Phe Thr Gly Ser Ala Ala Leu Ile Ala Val Val His Tyr Cys Asn Phe
            900                 905                 910         
Cys Gln Leu Ser Ser Trp Met Arg Ser Ser Leu Ala Thr Val Val Gly
        915                 920                 925             
Ala Gly Pro Leu Leu Leu Leu Tyr Val Ser Leu Cys Pro Asp Ser Ser
    930                 935                 940                 
Val Leu Thr Ser Pro Leu Asp Ala Val Gln Asn Phe Ser Ser Glu Arg
945                 950                 955                 960 
Asn Pro Cys Asn Ser Ser Val Pro Arg Asp Leu Arg Arg Pro Ala Ser
                965                 970                 975     
Leu Ile Gly Gln Glu Val Val Leu Val Phe Phe Leu Leu Leu Leu Leu
            980                 985                 990         
Val Trp Phe Leu Asn Arg Glu Phe Glu Val Ser Tyr Arg Leu His Tyr
        995                 1000                1005            
His Gly Asp Val Glu Ala Asp Leu His Arg Thr Lys Ile Gln Ser Met
    1010                1015                1020                
Arg Asp Gln Ala Asp Trp Leu Leu Arg Asn Ile Ile Pro Tyr His Val
1025                1030                1035                1040
Ala Glu Gln Leu Lys Val Ser Gln Thr Tyr Ser Lys Asn His Asp Ser
                1045                1050                1055    
Gly Gly Val Ile Phe Ala Ser Ile Val Asn Phe Ser Glu Phe Tyr Glu
            1060                1065                1070        
Glu Asn Tyr Glu Gly Gly Lys Glu Cys Tyr Arg Val Leu Asn Glu Leu
        1075                1080                1085            
Ile Gly Asp Phe Asp Glu Leu Leu Ser Lys Pro Asp Tyr Ser Ser Ile
    1090                1095                1100                
Glu Lys Ile Lys Thr Ile Gly Ala Thr Tyr Met Ala Ala Ser Gly Leu
1105                1110                1115                1120
Asn Thr Ala Gln Ala Gln Asp Gly Ser His Pro Gln Glu His Leu Gln
                1125                1130                1135    
Ile Leu Phe Glu Phe Ala Lys Glu Met Met Arg Val Val Asp Asp Phe
            1140                1145                1150        
Asn Asn Asn Met Leu Trp Phe Asn Phe Lys Leu Arg Val Gly Phe Asn
        1155                1160                1165            
His Gly Pro Leu Thr Ala Gly Val Ile Gly Thr Thr Lys Leu Leu Tyr
    1170                1175                1180                
Asp Ile Trp Gly Asp Thr Val Asn Ile Ala Ser Arg Met Asp Thr Thr
1185                1190                1195                1200
Gly Val Glu Cys Arg Ile Gln Val Ser Glu Glu Ser Tyr Arg Val Leu
                1205                1210                1215    
Ser Lys Met Gly Tyr Asp Phe Asp Tyr Arg Gly Thr Val Asn Val Lys
            1220                1225                1230        
Gly Lys Gly Gln Met Lys Thr Tyr Leu Tyr Pro Lys Cys Thr Asp His
        1235                1240                1245            
Arg Val Ile Pro Ala Pro Ala Val His Leu Pro Arg His Pro Arg Pro
    1250                1255                1260                
Gly Gly Trp Gln His Arg Thr Val Ser His Arg Arg Asp Cys Gln Pro
1265                1270                1275                1280
Gly Ala Phe Cys Pro Val Cys Gly Gln Asp Ile Ser Gly Phe
                1285                1290                


<210> 9298
<211> 1353
<212> PRT
<213> Homo sapiens

<400> 9298
Met Ala Ser Pro Pro His Gln Gln Leu Leu His His His Ser Thr Glu
 1               5                  10                  15      
Val Ser Cys Asp Ser Ser Gly Asp Ser Asn Ser Val Arg Val Lys Ile
            20                  25                  30          
Asn Pro Lys Gln Leu Ser Ser Asn Ser His Pro Lys His Cys Lys Tyr
        35                  40                  45              
Ser Ile Ser Ser Ser Cys Ser Ser Ser Gly Asp Ser Gly Gly Val Pro
    50                  55                  60                  
Arg Arg Val Gly Gly Gly Gly Arg Leu Arg Arg Gln Lys Lys Leu Pro
65                  70                  75                  80  
Gln Leu Phe Glu Arg Ala Ser Ser Arg Trp Trp Asp Pro Lys Phe Asp
                85                  90                  95      
Ser Val Asn Leu Glu Glu Ala Cys Leu Glu Arg Cys Phe Pro Gln Thr
            100                 105                 110         
Gln Arg Arg Phe Arg Tyr Ala Leu Phe Tyr Ile Gly Phe Ala Cys Leu
        115                 120                 125             
Leu Trp Ser Ile Tyr Phe Ala Val His Met Arg Ser Arg Leu Ile Val
    130                 135                 140                 
Met Val Ala Pro Ala Leu Cys Phe Leu Leu Val Cys Val Gly Phe Phe
145                 150                 155                 160 
Leu Phe Thr Phe Thr Lys Leu Tyr Ala Arg His Tyr Ala Trp Thr Ser
                165                 170                 175     
Leu Ala Leu Thr Leu Leu Val Phe Ala Leu Thr Leu Ala Ala Gln Phe
            180                 185                 190         
Gln Val Leu Thr Pro Val Ser Gly Arg Gly Asp Ser Ser Asn Leu Thr
        195                 200                 205             
Ala Thr Ala Arg Pro Thr Asp Thr Cys Leu Ser Gln Val Gly Ser Phe
    210                 215                 220                 
Ser Met Cys Ile Glu Val Leu Phe Leu Leu Tyr Thr Val Met His Leu
225                 230                 235                 240 
Pro Leu Tyr Leu Ser Leu Cys Leu Gly Val Ala Tyr Ser Val Leu Phe
                245                 250                 255     
Glu Thr Phe Gly Tyr His Phe Arg Asp Glu Ala Cys Phe Pro Ser Pro
            260                 265                 270         
Gly Ala Gly Ala Leu His Trp Glu Leu Leu Ser Arg Gly Leu Leu His
        275                 280                 285             
Gly Cys Ile His Ala Ile Gly Val His Leu Phe Val Met Ser Gln Val
    290                 295                 300                 
Arg Ser Arg Ser Thr Phe Leu Lys Val Gly Gln Ser Ile Met His Gly
305                 310                 315                 320 
Lys Asp Leu Glu Val Glu Lys Ala Leu Lys Glu Arg Met Ile His Ser
                325                 330                 335     
Val Met Pro Arg Ile Ile Ala Asp Asp Leu Met Lys Gln Gly Asp Glu
            340                 345                 350         
Glu Ser Glu Asn Ser Val Lys Arg His Ala Thr Ser Ser Pro Lys Asn
        355                 360                 365             
Arg Lys Lys Lys Ser Ser Ile Gln Lys Ala Pro Ile Ala Phe Arg Pro
    370                 375                 380                 
Phe Lys Met Gln Gln Ile Glu Glu Val Ser Ile Leu Phe Ala Asp Ile
385                 390                 395                 400 
Val Gly Phe Thr Lys Met Ser Ala Asn Lys Ser Ala His Ala Leu Val
                405                 410                 415     
Gly Leu Leu Asn Asp Leu Phe Gly Arg Phe Asp Arg Leu Cys Glu Glu
            420                 425                 430         
Thr Lys Cys Glu Lys Ile Ser Thr Leu Gly Asp Cys Tyr Tyr Cys Val
        435                 440                 445             
Ala Gly Cys Pro Glu Pro Arg Ala Asp His Ala Tyr Cys Cys Ile Glu
    450                 455                 460                 
Met Gly Leu Gly Met Ile Lys Ala Ile Glu Gln Phe Cys Gln Glu Lys
465                 470                 475                 480 
Lys Glu Met Val Asn Met Arg Val Gly Val His Thr Gly Thr Val Leu
                485                 490                 495     
Cys Gly Ile Leu Gly Met Arg Arg Phe Lys Phe Asp Val Trp Ser Asn
            500                 505                 510         
Asp Val Asn Leu Ala Asn Leu Met Glu Gln Leu Gly Val Ala Gly Lys
        515                 520                 525             
Val His Ile Ser Glu Ala Thr Ala Lys Tyr Leu Asp Asp Arg Tyr Glu
    530                 535                 540                 
Met Glu Asp Gly Lys Val Ile Glu Arg Leu Gly Gln Ser Val Val Ala
545                 550                 555                 560 
Asp Gln Leu Lys Gly Leu Lys Thr Tyr Leu Ile Ser Gly Gln Arg Ala
                565                 570                 575     
Lys Glu Ser Arg Cys Ser Cys Ala Glu Ala Leu Leu Ser Gly Phe Glu
            580                 585                 590         
Val Ile Asp Gly Ser Gln Val Ser Ser Gly Pro Arg Gly Gln Gly Thr
        595                 600                 605             
Ala Ser Ser Gly Asn Val Ser Asp Leu Ala Gln Thr Val Lys Thr Phe
    610                 615                 620                 
Asp Asn Leu Lys Thr Cys Pro Ser Cys Gly Ile Thr Phe Ala Pro Lys
625                 630                 635                 640 
Ser Glu Ala Gly Ala Glu Gly Gly Ala Pro Gln Asn Gly Cys Gln Asp
                645                 650                 655     
Glu His Lys Asn Ser Thr Lys Ala Ser Gly Gly Pro Asn Pro Lys Thr
            660                 665                 670         
Gln Asn Gly Leu Leu Ser Pro Pro Gln Glu Glu Lys Leu Thr Asn Ser
        675                 680                 685             
Gln Thr Ser Leu Cys Glu Ile Leu Gln Glu Lys Gly Arg Trp Ala Gly
    690                 695                 700                 
Val Ser Leu Asp Gln Ser Ala Leu Leu Pro Leu Arg Phe Lys Asn Ile
705                 710                 715                 720 
Arg Glu Lys Thr Asp Ala His Phe Val Asp Val Ile Lys Glu Asp Ser
                725                 730                 735     
Leu Met Lys Asp Tyr Phe Phe Lys Pro Pro Ile Asn Gln Phe Ser Leu
            740                 745                 750         
Asn Phe Leu Asp Gln Glu Leu Glu Arg Ser Tyr Arg Thr Ser Tyr Gln
        755                 760                 765             
Glu Glu Val Ile Lys Asn Ser Pro Val Lys Thr Phe Ala Ser Pro Thr
    770                 775                 780                 
Phe Ser Ser Leu Leu Asp Val Phe Leu Ser Thr Thr Val Phe Leu Thr
785                 790                 795                 800 
Leu Ser Thr Thr Cys Phe Leu Lys Tyr Glu Ala Ala Thr Val Pro Pro
                805                 810                 815     
Pro Pro Ala Ala Leu Ala Val Phe Ser Ala Ala Leu Leu Leu Glu Val
            820                 825                 830         
Leu Ser Leu Ala Val Ser Ile Arg Met Val Phe Phe Leu Glu Asp Val
        835                 840                 845             
Met Ala Cys Thr Lys Arg Leu Leu Glu Trp Ile Ala Gly Trp Leu Pro
    850                 855                 860                 
Arg His Cys Ile Gly Ala Ile Leu Val Ser Leu Pro Ala Leu Ala Val
865                 870                 875                 880 
Tyr Ser His Val Thr Ser Glu Tyr Glu Thr Asn Ile His Phe Pro Val
                885                 890                 895     
Phe Thr Gly Ser Ala Ala Leu Ile Ala Val Val His Tyr Cys Asn Phe
            900                 905                 910         
Cys Gln Leu Ser Ser Trp Met Arg Ser Ser Leu Ala Thr Val Val Gly
        915                 920                 925             
Ala Gly Pro Leu Leu Leu Leu Tyr Val Ser Leu Cys Pro Asp Ser Ser
    930                 935                 940                 
Val Leu Thr Ser Pro Leu Asp Ala Val Gln Asn Phe Ser Ser Glu Arg
945                 950                 955                 960 
Asn Pro Cys Asn Ser Ser Val Pro Arg Asp Leu Arg Arg Pro Ala Ser
                965                 970                 975     
Leu Ile Gly Gln Glu Val Val Leu Val Phe Phe Leu Leu Leu Leu Leu
            980                 985                 990         
Val Trp Phe Leu Asn Arg Glu Phe Glu Val Ser Tyr Arg Leu His Tyr
        995                 1000                1005            
His Gly Asp Val Glu Ala Asp Leu His Arg Thr Lys Ile Gln Ser Met
    1010                1015                1020                
Arg Asp Gln Ala Asp Trp Leu Leu Arg Asn Ile Ile Pro Tyr His Val
1025                1030                1035                1040
Ala Glu Gln Leu Lys Val Ser Gln Thr Tyr Ser Lys Asn His Asp Ser
                1045                1050                1055    
Gly Gly Val Ile Phe Ala Ser Ile Val Asn Phe Ser Glu Phe Tyr Glu
            1060                1065                1070        
Glu Asn Tyr Glu Gly Gly Lys Glu Cys Tyr Arg Val Leu Asn Glu Leu
        1075                1080                1085            
Ile Gly Asp Phe Asp Glu Leu Leu Ser Lys Pro Asp Tyr Ser Ser Ile
    1090                1095                1100                
Glu Lys Ile Lys Thr Ile Gly Ala Thr Tyr Met Ala Ala Ser Gly Leu
1105                1110                1115                1120
Asn Thr Ala Gln Ala Gln Asp Gly Ser His Pro Gln Glu His Leu Gln
                1125                1130                1135    
Ile Leu Phe Glu Phe Ala Lys Glu Met Met Arg Val Val Asp Asp Phe
            1140                1145                1150        
Asn Asn Asn Met Leu Trp Phe Asn Phe Lys Leu Arg Val Gly Phe Asn
        1155                1160                1165            
His Gly Pro Leu Thr Ala Gly Val Ile Gly Thr Thr Lys Leu Leu Tyr
    1170                1175                1180                
Asp Ile Trp Gly Asp Thr Val Asn Ile Ala Ser Arg Met Asp Thr Thr
1185                1190                1195                1200
Gly Val Glu Cys Arg Ile Gln Val Ser Glu Glu Ser Tyr Arg Val Leu
                1205                1210                1215    
Ser Lys Met Gly Tyr Asp Phe Asp Tyr Arg Gly Thr Val Asn Val Lys
            1220                1225                1230        
Gly Lys Gly Gln Met Lys Thr Tyr Leu Tyr Pro Lys Cys Thr Asp His
        1235                1240                1245            
Arg Val Ile Pro Gln His Gln Leu Ser Ile Ser Pro Asp Ile Arg Val
    1250                1255                1260                
Gln Val Asp Gly Ser Ile Gly Arg Ser Pro Thr Asp Glu Ile Ala Asn
1265                1270                1275                1280
Leu Val Pro Ser Val Gln Tyr Val Asp Lys Thr Ser Leu Gly Ser Asp
                1285                1290                1295    
Ser Ser Thr Gln Ala Lys Asp Ala His Leu Ser Pro Lys Arg Pro Trp
            1300                1305                1310        
Lys Glu Pro Val Lys Ala Glu Glu Arg Gly Arg Phe Gly Lys Ala Ile
        1315                1320                1325            
Glu Lys Asp Asp Cys Asp Glu Thr Gly Ile Glu Glu Ala Asn Glu Leu
    1330                1335                1340                
Thr Lys Leu Asn Val Ser Lys Ser Val
1345                1350            


<210> 9299
<211> 497
<212> PRT
<213> Homo sapiens

<400> 9299
Met Ala Asp Pro Glu Val Val Val Cys Ser Cys Ser Ser His Glu Glu
 1               5                  10                  15      
Glu Asn Arg Cys Asn Phe Asn Gln Gln Thr Ser Pro Ser Glu Glu Leu
            20                  25                  30          
Leu Leu Glu Asp Gln Met Arg Arg Lys Leu Lys Phe Phe Phe Met Asn
        35                  40                  45              
Pro Cys Glu Lys Phe Trp Ala Arg Gly Arg Lys Pro Trp Lys Leu Ala
    50                  55                  60                  
Ile Gln Ile Leu Lys Ile Ala Met Val Thr Ile Gln Tyr Leu Gln Leu
65                  70                  75                  80  
Tyr Asn Val Ser Val Gly Asn His Ala Tyr Glu Asn Lys Gly Thr Lys
                85                  90                  95      
Gln Ser Ala Met Ala Ile Cys Gln His Phe Tyr Lys Arg Gly Asn Ile
            100                 105                 110         
Tyr Pro Gly Asn Asp Thr Phe Asp Ile Asp Pro Glu Ile Glu Thr Glu
        115                 120                 125             
Cys Phe Phe Val Glu Pro Asp Glu Pro Phe His Ile Gly Thr Pro Ala
    130                 135                 140                 
Glu Asn Lys Leu Asn Leu Thr Leu Asp Phe His Arg Leu Leu Thr Val
145                 150                 155                 160 
Glu Leu Gln Phe Lys Leu Lys Ala Ile Asn Leu Gln Thr Val Arg His
                165                 170                 175     
Gln Glu Leu Pro Asp Cys Tyr Asp Phe Thr Leu Thr Ile Thr Phe Asp
            180                 185                 190         
Asn Lys Ala His Ser Gly Arg Ile Lys Ile Ser Leu Asp Asn Asp Ile
        195                 200                 205             
Ser Ile Arg Glu Cys Lys Asp Trp His Val Ser Gly Ser Ile Gln Lys
    210                 215                 220                 
Asn Thr His Tyr Met Met Ile Phe Asp Ala Phe Val Ile Leu Thr Cys
225                 230                 235                 240 
Leu Val Ser Leu Ile Leu Cys Ile Arg Ser Val Ile Arg Gly Leu Gln
                245                 250                 255     
Leu Gln Gln Glu Phe Val Asn Phe Phe Leu Leu His Tyr Lys Lys Glu
            260                 265                 270         
Val Ser Val Ser Asp Gln Met Glu Phe Val Asn Gly Trp Tyr Ile Met
        275                 280                 285             
Ile Ile Ile Ser Asp Ile Leu Thr Ile Ile Gly Ser Ile Leu Lys Met
    290                 295                 300                 
Glu Ile Gln Ala Lys Ser Leu Thr Ser Tyr Asp Val Cys Ser Ile Leu
305                 310                 315                 320 
Leu Gly Thr Ser Thr Met Leu Val Trp Leu Gly Val Ile Arg Tyr Leu
                325                 330                 335     
Gly Phe Phe Ala Lys Tyr Asn Leu Leu Ile Leu Thr Leu Gln Ala Ala
            340                 345                 350         
Leu Pro Asn Val Ile Arg Phe Cys Cys Cys Ala Ala Met Ile Tyr Leu
        355                 360                 365             
Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
    370                 375                 380                 
Phe Arg Ser Leu Asn Met Val Ser Glu Cys Leu Phe Ser Leu Ile Asn
385                 390                 395                 400 
Gly Asp Asp Met Phe Ala Thr Phe Ala Lys Met Gln Gln Lys Ser Tyr
                405                 410                 415     
Leu Val Trp Leu Phe Ser Arg Ile Tyr Leu Tyr Ser Phe Ile Ser Leu
            420                 425                 430         
Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Thr
        435                 440                 445             
Tyr Glu Thr Ile Lys Gln Tyr Gln Gln Asp Gly Phe Pro Glu Thr Glu
    450                 455                 460                 
Leu Arg Thr Phe Ile Ser Glu Cys Lys Asp Leu Pro Asn Ser Gly Lys
465                 470                 475                 480 
Tyr Arg Leu Glu Asp Asp Pro Pro Val Ser Leu Phe Cys Cys Cys Lys
                485                 490                 495     
Lys
    


<210> 9300
<211> 553
<212> PRT
<213> Homo sapiens

<400> 9300
Met Ala Asp Pro Glu Val Val Val Ser Ser Cys Ser Ser His Glu Glu
 1               5                  10                  15      
Glu Asn Arg Cys Asn Phe Asn Gln Gln Thr Ser Pro Ser Glu Glu Leu
            20                  25                  30          
Leu Leu Glu Asp Gln Met Arg Arg Lys Leu Lys Phe Phe Phe Met Asn
        35                  40                  45              
Pro Cys Glu Lys Phe Trp Ala Arg Gly Arg Lys Pro Trp Lys Leu Ala
    50                  55                  60                  
Ile Gln Ile Leu Lys Ile Ala Met Val Thr Ile Gln Leu Val Leu Phe
65                  70                  75                  80  
Gly Leu Ser Asn Gln Met Val Val Ala Phe Lys Glu Glu Asn Thr Ile
                85                  90                  95      
Ala Phe Lys His Leu Phe Leu Lys Gly Tyr Met Asp Arg Met Asp Asp
            100                 105                 110         
Thr Tyr Ala Val Tyr Thr Gln Ser Asp Val Tyr Asp Gln Leu Ile Phe
        115                 120                 125             
Ala Val Asn Gln Tyr Leu Gln Leu Tyr Asn Val Ser Val Gly Asn His
    130                 135                 140                 
Ala Tyr Glu Asn Lys Gly Thr Lys Gln Ser Ala Met Ala Ile Cys Gln
145                 150                 155                 160 
His Phe Tyr Lys Arg Gly Asn Ile Tyr Pro Gly Asn Asp Thr Phe Asp
                165                 170                 175     
Ile Asp Pro Glu Ile Glu Thr Glu Cys Phe Phe Val Glu Pro Asp Glu
            180                 185                 190         
Pro Phe His Ile Gly Thr Pro Ala Glu Asn Lys Leu Asn Leu Thr Leu
        195                 200                 205             
Asp Phe His Arg Leu Leu Thr Val Glu Leu Gln Phe Lys Leu Lys Ala
    210                 215                 220                 
Ile Asn Leu Gln Thr Val Arg His Gln Glu Leu Pro Asp Cys Tyr Asp
225                 230                 235                 240 
Phe Thr Leu Thr Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile
                245                 250                 255     
Lys Ile Ser Leu Asp Asn Asp Ile Ser Ile Arg Glu Cys Lys Asp Trp
            260                 265                 270         
His Val Ser Gly Ser Ile Gln Lys Asn Thr His Tyr Met Met Ile Phe
        275                 280                 285             
Asp Ala Phe Val Ile Leu Thr Cys Leu Val Ser Leu Ile Leu Cys Ile
    290                 295                 300                 
Arg Ser Val Ile Arg Gly Leu Gln Leu Gln Gln Glu Phe Val Asn Phe
305                 310                 315                 320 
Phe Leu Leu His Tyr Lys Lys Glu Val Ser Val Ser Asp Gln Met Glu
                325                 330                 335     
Phe Val Asn Gly Trp Tyr Ile Met Ile Ile Ile Ser Asp Ile Leu Thr
            340                 345                 350         
Ile Ile Gly Ser Ile Leu Lys Met Glu Ile Gln Ala Lys Ser Leu Thr
        355                 360                 365             
Ser Tyr Asp Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Met Leu Val
    370                 375                 380                 
Trp Leu Gly Val Ile Arg Tyr Leu Gly Phe Phe Ala Lys Tyr Asn Leu
385                 390                 395                 400 
Leu Ile Leu Thr Leu Gln Ala Ala Leu Pro Asn Val Ile Arg Phe Cys
                405                 410                 415     
Cys Cys Ala Ala Met Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile
            420                 425                 430         
Val Leu Gly Pro Tyr His Asp Lys Phe Arg Ser Leu Asn Met Val Ser
        435                 440                 445             
Glu Cys Leu Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Ala Thr Phe
    450                 455                 460                 
Ala Lys Met Gln Gln Lys Ser Tyr Leu Val Trp Leu Phe Ser Arg Ile
465                 470                 475                 480 
Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu
                485                 490                 495     
Phe Ile Ala Leu Ile Thr Asp Thr Tyr Glu Thr Ile Lys Gln Tyr Gln
            500                 505                 510         
Gln Asp Gly Phe Pro Glu Thr Glu Leu Arg Thr Phe Ile Ser Glu Cys
        515                 520                 525             
Lys Asp Leu Pro Asn Ser Gly Lys Tyr Arg Leu Glu Asp Asp Pro Pro
    530                 535                 540                 
Val Ser Leu Phe Cys Cys Cys Lys Lys
545                 550             


<210> 9301
<211> 899
<212> PRT
<213> Homo sapiens

<400> 9301
Met Leu Ile Phe Thr Phe Ile Glu Cys Phe Leu Asn Ile Ser Gly Pro
 1               5                  10                  15      
Ser Arg Leu Cys Arg Gly Val Ser Ser Thr Ser Val Phe Leu Phe Pro
            20                  25                  30          
Ala Leu Asn Gly Tyr Leu Phe Gly Asn Phe Pro Glu Pro Asp Met Cys
        35                  40                  45              
Val Gly Glu Ser Val Ser Trp His Leu Phe Gly Met Gly Asn Glu Ile
    50                  55                  60                  
Asp Ile His Ser Ile Tyr Phe Tyr Gly Asn Thr Phe Ile Ser Arg Gly
65                  70                  75                  80  
His Arg Thr Asp Val Val Asn Leu Phe Pro Ala Thr Phe Leu Thr Thr
                85                  90                  95      
Glu Met Ile Ala Glu Asn Pro Gly Lys Trp Met Ile Thr Cys Gln Val
            100                 105                 110         
Ser Asp His Leu Gln Ala Gly Met Leu Gly Gln Tyr Asn Val Asp Asn
        115                 120                 125             
Cys Lys Ser Asp Ile Phe Tyr Pro Lys Met Lys Gly Gln Gln Arg Arg
    130                 135                 140                 
Tyr Phe Ile Ala Ala Glu Lys Ile Leu Trp Asp Tyr Ala Pro Gln Gly
145                 150                 155                 160 
Tyr Asn Lys Phe Ser Gly Leu Pro Leu Asn Ala Ser Gly Ser Asp Ser
                165                 170                 175     
Asp Leu Tyr Phe Thr Gln Gly Asp Asn Arg Ile Gly Gly Lys Tyr Trp
            180                 185                 190         
Lys Val Arg Tyr Thr Glu Phe Val Asp Ala Thr Phe Thr Lys Arg Lys
        195                 200                 205             
Arg Leu Ser Ala Glu Glu Ala His Leu Gly Ile Leu Gly Pro Val Ile
    210                 215                 220                 
Lys Ala Glu Val Gly Asp Thr Leu Leu Val Thr Phe Ala Asn Lys Ala
225                 230                 235                 240 
Asp Lys Val Tyr Ser Ile Leu Pro His Gly Val Ile Tyr Asp Lys Ala
                245                 250                 255     
Ser Asp Ala Ala Pro Asn Leu Asp Gly Phe Val Lys Pro Gly Ala His
            260                 265                 270         
Val Lys Pro Gly Glu Thr Phe Thr Tyr Lys Trp Thr Val Pro Glu Ser
        275                 280                 285             
Val Ser Pro Thr Ala Gly Asp Pro Pro Cys Leu Thr Tyr Leu Tyr Phe
    290                 295                 300                 
Ser Ala Val Asp Pro Ile Lys Asp Thr Ser Ser Gly Leu Val Gly Pro
305                 310                 315                 320 
Leu Leu Val Cys Lys Lys Gly Val Leu Asn Ala Asp Gly Thr Gln Lys
                325                 330                 335     
Gly Ile Asp Lys Glu Phe Tyr Leu Leu Phe Thr Val Phe Asp Glu Asn
            340                 345                 350         
Leu Ser Arg Tyr Phe Asp Glu Asn Ile Gln Lys Phe Ile Trp His Pro
        355                 360                 365             
Phe Ser Ile Asp Lys Glu Asp Lys Glu Phe Val Lys Ser Asn Arg Met
    370                 375                 380                 
His Ala Val Asn Gly Tyr Met Tyr Gly Asn Gln Pro Gly Leu Asn Met
385                 390                 395                 400 
Cys Lys Arg Asp Arg Val Ser Trp His Leu Ile Gly Leu Gly Thr Asp
                405                 410                 415     
Thr Asp Met His Gly Ile Val Phe Gln Gly Asn Thr Ile His Leu Arg
            420                 425                 430         
Gly Thr His Arg Asp Ser Leu Ala Leu Phe Pro His Met Ala Thr Thr
        435                 440                 445             
Ala Phe Met Gln Pro Asp His Ala Gly Ile Phe Arg Val Phe Cys Ala
    450                 455                 460                 
Thr Met Pro His Leu Ser Arg Gly Met Gly Gln Ile Tyr Glu Val Ser
465                 470                 475                 480 
Ser Cys Asp Asn Arg Asp Pro Ser Glu Gln Arg Tyr Gly Met Ile Arg
                485                 490                 495     
Thr Phe Tyr Ile Ala Ala Glu Glu Val Glu Trp Asp Tyr Ala Pro Asn
            500                 505                 510         
Lys Asn Trp Glu Phe Glu Lys Gln His Val Asp Ala Arg Gly Glu Arg
        515                 520                 525             
His Gly Asp Ile Phe Met Asn Arg Thr Glu Asn Trp Ile Gly Ser Gln
    530                 535                 540                 
Tyr Lys Lys Val Val Tyr Arg Glu Tyr Thr Asp Gly Glu Phe Val Glu
545                 550                 555                 560 
Ile Lys Ala Arg Pro Pro Arg Glu Glu His Leu Glu Leu Leu Gly Pro
                565                 570                 575     
Met Ile His Ala Glu Val Gly Asn Thr Val Leu Ile Ile Phe Lys Asn
            580                 585                 590         
Lys Ala Ser Arg Pro Tyr Ser Ile Ser Ala Gln Gly Val Glu Glu Met
        595                 600                 605             
Asp Ser Gly Lys Gln Phe Gln Val Pro Met Thr Lys Pro Gly Glu Val
    610                 615                 620                 
Lys Thr Tyr Arg Trp Asn Ile Pro Lys Arg Ser Gly Pro Gly Pro Ser
625                 630                 635                 640 
Asp Pro Asn Cys Ile Pro Trp Val Tyr Tyr Ser Thr Val Asn Phe Val
                645                 650                 655     
Lys Asp Thr Tyr Ser Gly Leu Met Gly Pro Leu Ile Thr Cys Arg Lys
            660                 665                 670         
Gly Val Leu Asn Glu Lys Gly Arg Arg Ser Asp Val Asp Tyr Glu Phe
        675                 680                 685             
Ala Leu Leu Phe Leu Val Phe Asn Glu Asn Glu Ser Trp Tyr Leu Asp
    690                 695                 700                 
Asp Asn Ile Lys Lys Tyr Leu Asn Lys Asp Pro Arg Asp Phe Lys Arg
705                 710                 715                 720 
Thr Asp Asp Phe Glu Glu Ser Asn Arg Met His Ala Ile Asn Gly Lys
                725                 730                 735     
Ile Phe Gly Asn Leu His Gly Leu Ile Met Asn Glu Asp Thr Met Thr
            740                 745                 750         
Asn Trp Tyr Leu Leu Gly Ile Gly Ser Glu Val Asp Ile His Thr Ile
        755                 760                 765             
His Tyr His Ala Glu Ser Phe Leu Phe Lys Ile Asp Lys Ser Tyr Arg
    770                 775                 780                 
Glu Asp Val Tyr Asp Leu Phe Pro Gly Thr Phe Gln Thr Ile Glu Leu
785                 790                 795                 800 
Phe Ala Asp His Pro Gly Thr Trp Leu Leu His Cys His Val Ser Asp
                805                 810                 815     
His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val Leu Arg Asn Ile
            820                 825                 830         
Glu Arg Pro Gly Lys Glu Gln Leu Tyr Phe Phe Gly Lys Asn Leu Gly
        835                 840                 845             
Pro Thr Gly Ala Lys Ala Ala Leu Val Ile Leu Phe Ile Ile Gly Leu
    850                 855                 860                 
Leu Leu Leu Ile Thr Thr Val Ile Leu Ser Leu Arg Leu Cys Ser Ala
865                 870                 875                 880 
Met Lys Gln Thr Asp Tyr Gln Gln Val Gln Ser Cys Ala Leu Pro Thr
                885                 890                 895     
Asp Ala Leu
            


<210> 9302
<211> 619
<212> PRT
<213> Homo sapiens

<400> 9302
Ile His Leu Lys Asn Phe Ala Ser Arg Pro Tyr Ser Leu His Pro His
 1               5                  10                  15      
Gly Val Phe Tyr Asn Lys Asp Ser Glu Gly Lys Tyr Gln Ser Phe Ile
            20                  25                  30          
Thr Gly Val Leu Ser Leu Phe His Lys Asn Asp Ser Arg Glu Ser Trp
        35                  40                  45              
Glu Val Asp Asp Asn Leu Pro Gly Ala His Val Lys Pro Gly Glu Thr
    50                  55                  60                  
Phe Thr Tyr Lys Trp Thr Val Pro Glu Ser Val Ser Pro Thr Ala Gly
65                  70                  75                  80  
Asp Pro Pro Cys Leu Thr Tyr Leu Tyr Phe Ser Ala Val Asp Pro Ile
                85                  90                  95      
Lys Asp Thr Ser Ser Gly Leu Val Gly Pro Leu Leu Val Cys Lys Lys
            100                 105                 110         
Gly Val Leu Asn Ala Asp Gly Thr Gln Lys Gly Ile Asp Lys Glu Phe
        115                 120                 125             
Tyr Leu Leu Phe Thr Val Phe Asp Glu Asn Leu Ser Arg Tyr Phe Asp
    130                 135                 140                 
Glu Asn Ile Gln Lys Phe Ile Trp His Pro Phe Ser Ile Asp Lys Glu
145                 150                 155                 160 
Asp Lys Glu Phe Val Lys Ser Asn Arg Met His Ala Val Asn Gly Tyr
                165                 170                 175     
Met Tyr Gly Asn Gln Pro Gly Leu Asn Met Cys Lys Arg Asp Arg Val
            180                 185                 190         
Ser Trp His Leu Ile Gly Leu Gly Thr Asp Thr Asp Met His Gly Ile
        195                 200                 205             
Val Phe Gln Gly Asn Thr Ile His Leu Arg Gly Thr His Arg Asp Ser
    210                 215                 220                 
Leu Ala Leu Phe Pro His Met Ala Thr Thr Ala Phe Met Gln Pro Asp
225                 230                 235                 240 
His Ala Gly Ile Phe Arg Val Phe Cys Ala Thr Met Pro His Leu Ser
                245                 250                 255     
Arg Gly Met Gly Gln Ile Tyr Glu Val Ser Ser Cys Asp Asn Arg Asp
            260                 265                 270         
Pro Ser Glu Gln Arg Tyr Gly Met Ile Arg Thr Phe Tyr Ile Ala Ala
        275                 280                 285             
Glu Glu Val Glu Trp Asp Tyr Ala Pro Asn Lys Asn Trp Glu Phe Glu
    290                 295                 300                 
Lys Gln His Val Asp Ala Arg Gly Glu Arg His Gly Asp Ile Phe Met
305                 310                 315                 320 
Asn Arg Thr Glu Asn Trp Ile Gly Ser Gln Tyr Lys Lys Val Val Tyr
                325                 330                 335     
Arg Glu Tyr Thr Asp Gly Glu Phe Val Glu Ile Lys Ala Arg Pro Pro
            340                 345                 350         
Arg Glu Glu His Leu Glu Leu Leu Gly Pro Met Ile His Ala Glu Val
        355                 360                 365             
Gly Asn Thr Val Leu Ile Ile Phe Lys Asn Lys Ala Ser Arg Pro Tyr
    370                 375                 380                 
Ser Ile Ser Ala Gln Gly Val Glu Glu Met Asp Ser Gly Lys Gln Phe
385                 390                 395                 400 
Gln Val Pro Met Thr Lys Pro Gly Glu Val Lys Thr Tyr Arg Trp Asn
                405                 410                 415     
Ile Pro Lys Arg Ser Gly Pro Gly Pro Ser Asp Pro Asn Cys Ile Pro
            420                 425                 430         
Trp Val Tyr Tyr Ser Thr Val Asn Phe Val Lys Asp Thr Tyr Ser Gly
        435                 440                 445             
Leu Met Gly Pro Leu Ile Thr Cys Arg Lys Gly Val Leu Asn Glu Lys
    450                 455                 460                 
Gly Arg Arg Ser Asp Val Asp Tyr Glu Phe Ala Leu Leu Phe Leu Val
465                 470                 475                 480 
Phe Asn Glu Asn Glu Ser Trp Tyr Leu Asp Asp Asn Ile Lys Lys Tyr
                485                 490                 495     
Leu Asn Lys Asp Pro Arg Asp Phe Lys Arg Thr Asp Asp Phe Glu Glu
            500                 505                 510         
Ser Asn Arg Met His Ala Ile Asn Gly Lys Ile Phe Gly Asn Leu His
        515                 520                 525             
Gly Leu Ile Met Asn Glu Asp Thr Met Thr Asn Trp Tyr Leu Leu Gly
    530                 535                 540                 
Ile Gly Ser Glu Val Asp Ile His Thr Ile His Tyr His Ala Glu Ser
545                 550                 555                 560 
Phe Leu Phe Lys Ile Asp Lys Ser Tyr Arg Glu Asp Val Tyr Asp Leu
                565                 570                 575     
Phe Pro Gly Thr Phe Gln Thr Ile Glu Leu Phe Ala Asp His Pro Gly
            580                 585                 590         
Thr Trp Leu Leu His Cys His Val Ser Asp His Ile His Ala Gly Met
        595                 600                 605             
Glu Thr Thr Tyr Thr Val Leu Arg Asn Ile Gly
    610                 615                 


<210> 9303
<211> 978
<212> PRT
<213> Homo sapiens

<400> 9303
Met Ser Thr Phe Val Ser Ser Val Lys Ser Ser Asp Ser Pro Thr Gln
 1               5                  10                  15      
His Ala Val Gly Phe Gln Lys Ala Phe Gln Leu Ile Arg Ser Thr Asn
            20                  25                  30          
Asn Asn Thr Lys Phe Gln Ala Asn Thr Asp Met Val Ile Ile Tyr Leu
        35                  40                  45              
Ser Ala Gly Ile Thr Ser Lys Asp Ser Ser Glu Glu Asp Lys Lys Ala
    50                  55                  60                  
Thr Leu Gln Val Ile Asn Glu Glu Asn Ser Phe Leu Asn Asn Ser Val
65                  70                  75                  80  
Met Ile Leu Thr Tyr Ala Leu Met Asn Asp Gly Val Thr Gly Leu Lys
                85                  90                  95      
Glu Leu Ala Phe Leu Arg Asp Leu Ala Glu Gln Asn Ser Gly Lys Tyr
            100                 105                 110         
Gly Val Pro Asp Arg Thr Ala Leu Pro Val Ile Lys Gly Ser Met Met
        115                 120                 125             
Val Leu Asn Gln Leu Ser Asn Leu Glu Thr Thr Val Gly Arg Phe Tyr
    130                 135                 140                 
Thr Asn Leu Pro Asn Arg Met Ile Asp Glu Ala Val Phe Ser Leu Pro
145                 150                 155                 160 
Phe Ser Asp Glu Met Gly Asp Gly Leu Ile Met Thr Val Ser Lys Pro
                165                 170                 175     
Cys Tyr Phe Gly Asn Leu Leu Leu Gly Ile Val Gly Val Asp Val Asn
            180                 185                 190         
Leu Ala Tyr Ile Leu Glu Asp Val Thr Tyr Tyr Gln Asp Ser Leu Ala
        195                 200                 205             
Ser Tyr Thr Phe Leu Ile Asp Asp Lys Gly Tyr Thr Leu Met His Pro
    210                 215                 220                 
Ser Leu Thr Arg Pro Tyr Leu Leu Ser Glu Pro Pro Leu His Thr Asp
225                 230                 235                 240 
Ile Ile His Tyr Glu Asn Ile Pro Lys Phe Glu Leu Val Arg Gln Asn
                245                 250                 255     
Ile Leu Ser Leu Pro Leu Gly Ser Gln Ile Ile Ala Val Pro Val Asn
            260                 265                 270         
Ser Ser Leu Ser Trp His Ile Asn Lys Leu Arg Glu Thr Gly Lys Glu
        275                 280                 285             
Ala Tyr Asn Val Ser Tyr Ala Trp Lys Met Val Gln Asp Thr Ser Phe
    290                 295                 300                 
Ile Leu Cys Ile Val Val Ile Gln Pro Glu Ile Pro Val Lys Gln Leu
305                 310                 315                 320 
Lys Asn Leu Asn Thr Val Pro Ser Ser Lys Leu Leu Tyr His Arg Leu
                325                 330                 335     
Asp Leu Leu Gly Gln Pro Ser Ala Cys Leu His Phe Lys Gln Leu Ala
            340                 345                 350         
Thr Leu Glu Ser Pro Thr Ile Met Leu Ser Ala Gly Ser Phe Ser Ser
        355                 360                 365             
Pro Tyr Glu His Leu Ser Gln Pro Glu Thr Lys Arg Met Val Glu His
    370                 375                 380                 
Tyr Thr Ala Tyr Leu Ser Asp Asn Thr Arg Leu Ile Ala Asn Pro Gly
385                 390                 395                 400 
Leu Lys Phe Ser Val Arg Asn Glu Val Met Ala Thr Ser His Val Thr
                405                 410                 415     
Asp Glu Trp Met Thr Gln Met Glu Met Ser Ser Leu Asn Thr Tyr Ile
            420                 425                 430         
Val Arg Arg Tyr Ile Ala Thr Pro Asn Gly Val Leu Arg Ile Tyr Pro
        435                 440                 445             
Gly Ser Leu Met Asp Lys Ala Phe Asp Pro Thr Arg Arg Gln Trp Tyr
    450                 455                 460                 
Leu His Ala Val Ala Asn Pro Gly Leu Ile Ser Leu Thr Gly Pro Tyr
465                 470                 475                 480 
Leu Asp Val Gly Gly Ala Gly Tyr Val Val Thr Ile Ser His Thr Ile
                485                 490                 495     
His Ser Ser Ser Thr Gln Leu Ser Ser Gly His Thr Val Ala Val Met
            500                 505                 510         
Gly Ile Asp Phe Thr Leu Arg Tyr Phe Tyr Lys Val Leu Met Asp Leu
        515                 520                 525             
Leu Pro Val Cys Asn Gln Asp Gly Gly Asn Lys Ile Arg Cys Phe Ile
    530                 535                 540                 
Met Glu Asp Arg Gly Tyr Leu Val Ala His Pro Thr Leu Ile Asp Pro
545                 550                 555                 560 
Lys Gly His Ala Pro Val Glu Gln Gln His Ile Thr His Lys Glu Pro
                565                 570                 575     
Leu Val Ala Asn Asp Ile Leu Asn His Pro Asn Phe Val Lys Lys Asn
            580                 585                 590         
Leu Cys Asn Ser Phe Ser Asp Arg Thr Val Gln Arg Phe Tyr Lys Phe
        595                 600                 605             
Asn Thr Ser Leu Ala Gly Asp Leu Thr Asn Leu Val His Gly Ser His
    610                 615                 620                 
Cys Ser Lys Tyr Arg Leu Ala Arg Ile Pro Gly Thr Asn Ala Phe Val
625                 630                 635                 640 
Gly Ile Val Asn Glu Thr Cys Asp Ser Leu Ala Phe Cys Ala Cys Ser
                645                 650                 655     
Met Val Asp Arg Leu Cys Leu Asn Cys His Arg Met Glu Gln Asn Glu
            660                 665                 670         
Cys Glu Cys Pro Cys Glu Cys Pro Leu Glu Val Asn Glu Cys Thr Gly
        675                 680                 685             
Asn Leu Thr Asn Ala Glu Asn Arg Asn Pro Ser Cys Glu Val His Leu
    690                 695                 700                 
Glu Pro Val Thr Tyr Thr Ala Ile Asp Pro Gly Leu Gln Asp Ala Leu
705                 710                 715                 720 
His Gln Cys Val Asn Ser Arg Cys Ser Gln Arg Leu Glu Ser Gly Asp
                725                 730                 735     
Cys Phe Gly Val Leu Asp Cys Glu Trp Cys Met Val Asp Ser Asp Gly
            740                 745                 750         
Lys Thr His Leu Asp Lys Pro Tyr Cys Ala Pro Gln Lys Glu Cys Phe
        755                 760                 765             
Gly Gly Ile Val Gly Ala Lys Ser Pro Tyr Val Asp Asp Met Gly Ala
    770                 775                 780                 
Ile Gly Asp Glu Val Ile Thr Leu Asn Met Ile Lys Ser Ala Pro Val
785                 790                 795                 800 
Gly Pro Val Ala Gly Gly Ile Met Gly Cys Ile Met Val Leu Val Leu
                805                 810                 815     
Ala Val Tyr Ala Tyr Arg His Gln Ile His Arg Arg Ser His Gln His
            820                 825                 830         
Met Ser Pro Leu Ala Ala Gln Glu Met Ser Val Arg Met Ser Asn Leu
        835                 840                 845             
Glu Asn Asp Arg Asp Glu Arg Asp Asp Asp Ser His Glu Asp Arg Gly
    850                 855                 860                 
Ile Ile Ser Asn Thr Arg Phe Ile Ala Ala Val Ile Glu Arg His Ala
865                 870                 875                 880 
His Ser Pro Glu Arg Arg Arg Arg Tyr Trp Gly Arg Ser Gly Thr Glu
                885                 890                 895     
Ser Asp His Gly Tyr Ser Thr Met Ser Pro Gln Glu Asp Ser Glu Asn
            900                 905                 910         
Pro Pro Cys Asn Asn Asp Pro Leu Ser Ala Gly Val Asp Val Gly Asn
        915                 920                 925             
His Asp Glu Asp Leu Asp Leu Asp Thr Pro Pro Gln Thr Ala Ala Leu
    930                 935                 940                 
Leu Ser His Lys Phe His His Tyr Arg Ser His His Pro Thr Leu His
945                 950                 955                 960 
His Ser His His Leu Gln Ala Ala Val Thr Val His Thr Val Asp Ala
                965                 970                 975     
Glu Cys
        


<210> 9304
<211> 1185
<212> PRT
<213> Homo sapiens

<400> 9304
Lys Lys Ile Arg Glu Lys Phe Asn Arg Tyr Leu Asp Val Val Asn Arg
 1               5                  10                  15      
Asn Lys Gln Val Val Glu Ala Ser Tyr Thr Ala His Leu Thr Ser Pro
            20                  25                  30          
Leu Thr Ala Ile Gln Asp Cys Cys Thr Ile Pro Pro Ser Met Met Glu
        35                  40                  45              
Phe Asp Gly Asn Phe Asn Thr Asn Val Ser Arg Thr Ile Ser Cys Asp
    50                  55                  60                  
Arg Leu Ser Thr Thr Val Asn Ser Arg Ala Phe Asn Pro Gly Arg Asp
65                  70                  75                  80  
Leu Asn Ser Val Leu Ala Asp Asn Leu Lys Ser Asn Pro Gly Ile Lys
                85                  90                  95      
Trp Gln Tyr Phe Ser Ser Glu Glu Gly Ile Phe Thr Val Phe Pro Ala
            100                 105                 110         
His Lys Phe Arg Cys Lys Gly Ser Tyr Glu His Arg Ser Arg Pro Ile
        115                 120                 125             
Tyr Val Ser Thr Val Arg Pro Gln Ser Lys His Ile Val Val Ile Leu
    130                 135                 140                 
Asp His Gly Ala Ser Val Thr Asp Thr Gln Leu Gln Ile Ala Lys Asp
145                 150                 155                 160 
Ala Ala Gln Val Ile Leu Ser Ala Ile Asp Glu His Asp Lys Ile Ser
                165                 170                 175     
Val Leu Thr Val Ala Asp Thr Val Arg Thr Cys Ser Leu Asp Gln Cys
            180                 185                 190         
Tyr Lys Thr Phe Leu Ser Pro Ala Thr Ser Glu Thr Lys Arg Lys Met
        195                 200                 205             
Ser Thr Phe Val Ser Ser Val Lys Ser Ser Asp Ser Pro Thr Gln His
    210                 215                 220                 
Ala Val Gly Phe Gln Lys Ala Phe Gln Leu Ile Arg Ser Thr Asn Asn
225                 230                 235                 240 
Asn Thr Lys Phe Gln Ala Asn Thr Asp Met Val Ile Ile Tyr Leu Ser
                245                 250                 255     
Ala Gly Ile Thr Ser Lys Asp Ser Ser Glu Glu Asp Lys Lys Ala Thr
            260                 265                 270         
Leu Gln Val Ile Asn Glu Glu Asn Ser Phe Leu Asn Asn Ser Val Met
        275                 280                 285             
Ile Leu Thr Tyr Ala Leu Met Asn Asp Gly Val Thr Gly Leu Lys Glu
    290                 295                 300                 
Leu Ala Phe Leu Arg Asp Leu Ala Glu Gln Asn Ser Gly Lys Tyr Gly
305                 310                 315                 320 
Val Pro Asp Arg Thr Ala Leu Pro Val Ile Lys Gly Ser Met Met Val
                325                 330                 335     
Leu Asn Gln Leu Ser Asn Leu Glu Thr Thr Val Gly Arg Phe Tyr Thr
            340                 345                 350         
Asn Leu Pro Asn Arg Met Ile Asp Glu Ala Val Phe Ser Leu Pro Phe
        355                 360                 365             
Ser Asp Glu Met Gly Asp Gly Leu Ile Met Thr Val Ser Lys Pro Cys
    370                 375                 380                 
Tyr Phe Gly Asn Leu Leu Leu Gly Ile Val Gly Val Asp Val Asn Leu
385                 390                 395                 400 
Ala Tyr Ile Leu Glu Asp Val Thr Tyr Tyr Gln Asp Ser Leu Ala Ser
                405                 410                 415     
Tyr Thr Phe Leu Ile Asp Asp Lys Gly Tyr Thr Leu Met His Pro Ser
            420                 425                 430         
Leu Thr Arg Pro Tyr Leu Leu Ser Glu Pro Pro Leu His Thr Asp Ile
        435                 440                 445             
Ile His Tyr Glu Asn Ile Pro Lys Phe Glu Leu Val Arg Gln Asn Ile
    450                 455                 460                 
Leu Ser Leu Pro Leu Gly Ser Gln Ile Ile Ala Val Pro Val Asn Ser
465                 470                 475                 480 
Ser Leu Ser Trp His Ile Asn Lys Leu Arg Glu Thr Gly Lys Glu Ala
                485                 490                 495     
Tyr Asn Val Ser Tyr Ala Trp Lys Met Val Gln Asp Thr Ser Phe Ile
            500                 505                 510         
Leu Cys Ile Val Val Ile Gln Pro Glu Ile Pro Val Lys Gln Leu Lys
        515                 520                 525             
Asn Leu Asn Thr Val Pro Ser Ser Lys Leu Leu Tyr His Arg Leu Asp
    530                 535                 540                 
Leu Leu Gly Gln Pro Ser Ala Cys Leu His Phe Lys Gln Leu Ala Thr
545                 550                 555                 560 
Leu Glu Ser Pro Thr Ile Met Leu Ser Ala Gly Ser Phe Ser Ser Pro
                565                 570                 575     
Tyr Glu His Leu Ser Gln Pro Glu Thr Lys Arg Met Val Glu His Tyr
            580                 585                 590         
Thr Ala Tyr Leu Ser Asp Asn Thr Arg Leu Ile Ala Asn Pro Gly Leu
        595                 600                 605             
Lys Phe Ser Val Arg Asn Glu Val Met Ala Thr Ser His Val Thr Asp
    610                 615                 620                 
Glu Trp Met Thr Gln Met Glu Met Ser Ser Leu Asn Thr Tyr Ile Val
625                 630                 635                 640 
Arg Arg Tyr Ile Ala Thr Pro Asn Gly Val Leu Arg Ile Tyr Pro Gly
                645                 650                 655     
Ser Leu Met Asp Lys Ala Phe Asp Pro Thr Arg Arg Gln Trp Tyr Leu
            660                 665                 670         
His Ala Val Ala Asn Pro Gly Leu Ile Ser Leu Thr Gly Pro Tyr Leu
        675                 680                 685             
Asp Val Gly Gly Ala Gly Tyr Val Val Thr Ile Ser His Thr Ile His
    690                 695                 700                 
Ser Ser Ser Thr Gln Leu Ser Ser Gly His Thr Val Ala Val Met Gly
705                 710                 715                 720 
Ile Asp Phe Thr Leu Arg Tyr Phe Tyr Lys Val Leu Met Asp Leu Leu
                725                 730                 735     
Pro Val Cys Asn Gln Asp Gly Gly Asn Lys Ile Arg Cys Phe Ile Met
            740                 745                 750         
Glu Asp Arg Gly Tyr Leu Val Ala His Pro Thr Leu Ile Asp Pro Lys
        755                 760                 765             
Gly His Ala Pro Val Glu Gln Gln His Ile Thr His Lys Glu Pro Leu
    770                 775                 780                 
Val Ala Asn Asp Ile Leu Asn His Pro Asn Phe Val Lys Lys Asn Leu
785                 790                 795                 800 
Cys Asn Ser Phe Ser Asp Arg Thr Val Gln Arg Phe Tyr Lys Phe Asn
                805                 810                 815     
Thr Ser Leu Ala Gly Asp Leu Thr Asn Leu Val His Gly Ser His Cys
            820                 825                 830         
Ser Lys Tyr Arg Leu Ala Arg Ile Pro Gly Thr Asn Ala Phe Val Gly
        835                 840                 845             
Ile Val Asn Glu Thr Cys Asp Ser Leu Ala Phe Cys Ala Cys Ser Met
    850                 855                 860                 
Val Asp Arg Leu Cys Leu Asn Cys His Arg Met Glu Gln Asn Glu Cys
865                 870                 875                 880 
Glu Cys Pro Cys Glu Cys Pro Leu Glu Val Asn Glu Cys Thr Gly Asn
                885                 890                 895     
Leu Thr Asn Ala Glu Asn Arg Asn Pro Ser Cys Glu Val His Gln Glu
            900                 905                 910         
Pro Val Thr Tyr Thr Ala Ile Asp Pro Gly Leu Gln Asp Ala Leu His
        915                 920                 925             
Gln Cys Val Asn Ser Arg Cys Ser Gln Arg Leu Glu Ser Gly Asp Cys
    930                 935                 940                 
Phe Gly Val Leu Asp Cys Glu Trp Cys Met Val Asp Ser Asp Gly Lys
945                 950                 955                 960 
Thr His Leu Asp Lys Pro Tyr Cys Ala Pro Gln Lys Glu Cys Phe Gly
                965                 970                 975     
Gly Ile Val Gly Ala Lys Ser Pro Tyr Val Asp Asp Met Gly Ala Ile
            980                 985                 990         
Gly Asp Glu Val Ile Thr Leu Asn Met Ile Lys Ser Ala Pro Val Gly
        995                 1000                1005            
Pro Val Ala Gly Gly Ile Met Gly Cys Ile Met Val Leu Val Leu Ala
    1010                1015                1020                
Val Tyr Ala Tyr Arg His Gln Ile His Arg Arg Ser His Gln His Met
1025                1030                1035                1040
Ser Pro Leu Ala Ala Gln Glu Met Ser Val Arg Met Ser Asn Leu Glu
                1045                1050                1055    
Asn Asp Arg Asp Glu Arg Asp Asp Asp Ser His Glu Asp Arg Gly Ile
            1060                1065                1070        
Ile Ser Asn Thr Arg Phe Ile Ala Ala Val Ile Glu Arg His Ala His
        1075                1080                1085            
Ser Pro Glu Arg Arg Arg Arg Tyr Trp Gly Arg Ser Gly Thr Glu Ser
    1090                1095                1100                
Asp His Gly Tyr Ser Thr Met Ser Pro Gln Glu Asp Ser Glu Asn Pro
1105                1110                1115                1120
Pro Cys Asn Asn Asp Pro Leu Ser Ala Gly Val Asp Val Gly Asn His
                1125                1130                1135    
Asp Glu Asp Leu Asp Leu Asp Thr Pro Pro Gln Thr Ala Ala Leu Leu
            1140                1145                1150        
Ser His Lys Phe His His Tyr Arg Ser His His Pro Thr Leu His His
        1155                1160                1165            
Ser His His Leu Gln Ala Ala Val Thr Val His Thr Val Asp Ala Glu
    1170                1175                1180                
Cys
1185


<210> 9305
<211> 608
<212> PRT
<213> Homo sapiens

<400> 9305
Gly Ala Ser Arg Lys Trp Glu Lys Arg Arg Pro Lys Ala Gly Trp Arg
 1               5                  10                  15      
Ala Gly Gly Ser Arg Tyr Leu Pro Ser Ser Leu Ser Arg Cys Gly Leu
            20                  25                  30          
Leu Gly Arg Trp Arg Gly Arg Gly Trp Ala Arg Arg Tyr Gly Ile Phe
        35                  40                  45              
Glu Arg Cys Lys Glu Leu Val Glu Ala Gly Tyr Asp Val Arg Gln Pro
    50                  55                  60                  
Asp Lys Glu Asn Val Ser Leu Leu His Trp Ala Ala Ile Asn Asn Arg
65                  70                  75                  80  
Leu Asp Leu Val Arg Phe Tyr Ile Ser Lys Gly Ala Val Val Asp Gln
                85                  90                  95      
Leu Gly Gly Asp Leu Asn Ser Thr Pro Leu His Trp Ala Ile Arg Gln
            100                 105                 110         
Gly His Leu Pro Met Val Ile Leu Leu Leu Gln His Gly Ala Asp Pro
        115                 120                 125             
Thr Leu Ile Asp Gly Glu Gly Phe Ser Ser Ile His Leu Ala Val Leu
    130                 135                 140                 
Phe Gln His Met Pro Ile Ile Ala Tyr Leu Ile Ser Lys Gly Gln Ser
145                 150                 155                 160 
Val Asn Met Thr Asp Val Asn Gly Gln Thr Pro Leu Met Leu Ser Ala
                165                 170                 175     
His Lys Val Ile Gly Pro Glu Pro Thr Gly Phe Leu Leu Lys Phe Asn
            180                 185                 190         
Pro Ser Leu Asn Val Val Asp Lys Ile His Gln Asn Thr Pro Leu His
        195                 200                 205             
Trp Ala Val Ala Ala Gly Asn Val Asn Ala Val Asp Lys Leu Leu Glu
    210                 215                 220                 
Ala Gly Ser Ser Leu Asp Ile Gln Asn Val Lys Gly Glu Thr Pro Leu
225                 230                 235                 240 
Asp Met Ala Leu Gln Asn Lys Asn Gln Leu Ile Ile His Met Leu Lys
                245                 250                 255     
Thr Glu Ala Lys Met Arg Ala Asn Gln Lys Phe Arg Leu Trp Arg Trp
            260                 265                 270         
Leu Gln Lys Cys Glu Leu Phe Leu Leu Leu Met Leu Ser Val Ile Thr
        275                 280                 285             
Met Trp Ala Ile Gly Tyr Ile Leu Asp Phe Asn Ser Asp Ser Trp Leu
    290                 295                 300                 
Leu Lys Gly Cys Leu Leu Val Thr Leu Phe Phe Leu Thr Ser Leu Phe
305                 310                 315                 320 
Pro Arg Phe Leu Val Gly Tyr Lys Asn Leu Val Tyr Leu Pro Thr Ala
                325                 330                 335     
Phe Leu Leu Ser Ser Val Phe Trp Ile Phe Met Thr Trp Phe Ile Leu
            340                 345                 350         
Phe Phe Pro Asp Leu Ala Gly Ala Pro Phe Tyr Phe Ser Phe Ile Phe
        355                 360                 365             
Ser Ile Val Ala Phe Leu Tyr Phe Phe Tyr Lys Thr Trp Ala Thr Asp
    370                 375                 380                 
Pro Gly Phe Thr Lys Ala Ser Glu Glu Glu Lys Lys Val Asn Ile Ile
385                 390                 395                 400 
Thr Leu Ala Glu Thr Gly Ser Leu Asp Phe Arg Thr Phe Cys Thr Ser
                405                 410                 415     
Cys Leu Ile Arg Lys Pro Leu Arg Ser Leu His Cys His Val Cys Asn
            420                 425                 430         
Cys Cys Val Ala Arg Tyr Asp Gln His Cys Leu Trp Thr Gly Arg Cys
        435                 440                 445             
Ile Gly Phe Gly Asn His His Tyr Tyr Ile Phe Phe Leu Phe Phe Leu
    450                 455                 460                 
Ser Met Val Cys Gly Trp Ile Ile Tyr Gly Ser Phe Ile Tyr Leu Ser
465                 470                 475                 480 
Ser His Cys Ala Thr Thr Phe Lys Glu Asp Gly Leu Trp Thr Tyr Leu
                485                 490                 495     
Asn Gln Ile Val Ala Cys Ser Pro Trp Val Leu Tyr Ile Leu Met Leu
            500                 505                 510         
Ala Thr Phe His Phe Ser Trp Ser Thr Phe Leu Leu Leu Asn Gln Leu
        515                 520                 525             
Phe Gln Ile Ala Phe Leu Gly Leu Thr Ser His Glu Arg Ile Ser Leu
    530                 535                 540                 
Gln Lys Gln Ser Lys His Met Lys Gln Thr Leu Ser Leu Arg Lys Thr
545                 550                 555                 560 
Pro Tyr Asn Leu Gly Phe Met Gln Asn Leu Ala Asp Phe Phe Gln Cys
                565                 570                 575     
Gly Cys Phe Gly Leu Val Lys Pro Cys Val Val Asp Trp Thr Ser Gln
            580                 585                 590         
Tyr Thr Met Val Phe His Pro Ala Arg Glu Lys Val Leu Arg Ser Val
        595                 600                 605             


<210> 9306
<211> 622
<212> PRT
<213> Homo sapiens

<400> 9306
Met Glu Gly Pro Gly Leu Gly Ser Gln Cys Arg Asn His Ser His Gly
 1               5                  10                  15      
Pro His Pro Pro Gly Phe Gly Arg Tyr Gly Ile Cys Ala His Glu Asn
            20                  25                  30          
Lys Glu Leu Ala Asn Ala Arg Glu Ala Leu Pro Leu Ile Glu Asp Ser
        35                  40                  45              
Ser Asn Cys Asp Ile Val Lys Ala Thr Gln Tyr Gly Ile Phe Glu Arg
    50                  55                  60                  
Cys Lys Glu Leu Val Glu Ala Gly Tyr Asp Val Arg Gln Pro Asp Lys
65                  70                  75                  80  
Glu Asn Val Ser Leu Leu His Trp Ala Ala Ile Asn Asn Arg Leu Asp
                85                  90                  95      
Leu Val Arg Phe Tyr Ile Ser Lys Gly Ala Val Val Asp Gln Leu Gly
            100                 105                 110         
Gly Asp Leu Asn Ser Thr Pro Leu His Trp Ala Ile Arg Gln Gly His
        115                 120                 125             
Leu Pro Met Val Ile Leu Leu Leu Gln His Gly Ala Asp Pro Thr Leu
    130                 135                 140                 
Ile Asp Gly Glu Gly Phe Ser Ser Ile His Leu Ala Val Leu Phe Gln
145                 150                 155                 160 
His Met Pro Ile Ile Ala Tyr Leu Ile Ser Lys Gly Gln Ser Val Asn
                165                 170                 175     
Met Thr Asp Val Asn Gly Gln Thr Pro Leu Met Leu Ser Ala His Lys
            180                 185                 190         
Val Ile Gly Pro Glu Pro Thr Gly Phe Leu Leu Lys Phe Asn Pro Ser
        195                 200                 205             
Leu Asn Val Val Asp Lys Ile His Gln Asn Thr Pro Leu His Trp Ala
    210                 215                 220                 
Val Ala Ala Gly Asn Val Asn Ala Val Asp Lys Leu Leu Glu Ala Gly
225                 230                 235                 240 
Ser Ser Leu Asp Ile Gln Asn Val Lys Gly Glu Thr Pro Leu Asp Met
                245                 250                 255     
Ala Leu Gln Asn Lys Asn Gln Leu Ile Ile His Met Leu Lys Thr Glu
            260                 265                 270         
Ala Lys Met Arg Ala Asn Gln Lys Phe Arg Leu Trp Arg Trp Leu Gln
        275                 280                 285             
Lys Cys Glu Leu Phe Leu Leu Leu Met Leu Ser Val Ile Thr Met Trp
    290                 295                 300                 
Ala Ile Gly Tyr Ile Leu Asp Phe Asn Ser Asp Ser Trp Leu Leu Lys
305                 310                 315                 320 
Gly Cys Leu Leu Val Thr Leu Phe Phe Leu Thr Ser Leu Phe Pro Arg
                325                 330                 335     
Phe Leu Val Gly Tyr Lys Asn Leu Val Tyr Leu Pro Thr Ala Phe Leu
            340                 345                 350         
Leu Ser Ser Val Phe Trp Ile Phe Met Thr Trp Phe Ile Leu Phe Phe
        355                 360                 365             
Pro Asp Leu Ala Gly Ala Pro Phe Tyr Phe Ser Phe Ile Phe Ser Ile
    370                 375                 380                 
Val Ala Phe Leu Tyr Phe Phe Tyr Lys Thr Trp Ala Thr Asp Pro Gly
385                 390                 395                 400 
Phe Thr Lys Ala Ser Glu Glu Glu Lys Lys Val Asn Ile Ile Thr Leu
                405                 410                 415     
Ala Glu Thr Gly Ser Leu Asp Phe Arg Thr Phe Cys Thr Ser Cys Leu
            420                 425                 430         
Ile Arg Lys Pro Leu Arg Ser Leu His Cys His Val Cys Asn Cys Cys
        435                 440                 445             
Val Ala Arg Tyr Asp Gln His Cys Leu Trp Thr Gly Arg Cys Ile Gly
    450                 455                 460                 
Phe Gly Thr His His Tyr Tyr Ile Phe Phe Leu Phe Phe Leu Ser Met
465                 470                 475                 480 
Val Cys Gly Trp Ile Ile Tyr Gly Ser Phe Ile Tyr Leu Ser Ser His
                485                 490                 495     
Cys Ala Thr Thr Phe Lys Glu Asp Gly Leu Trp Thr Tyr Leu Asn Gln
            500                 505                 510         
Ile Val Ala Cys Ser Pro Trp Val Leu Tyr Ile Leu Met Leu Ala Thr
        515                 520                 525             
Phe His Phe Ser Trp Ser Thr Phe Leu Leu Leu Asn Gln Leu Phe Gln
    530                 535                 540                 
Ile Ala Phe Leu Gly Leu Thr Ser His Glu Arg Ile Ser Leu Gln Lys
545                 550                 555                 560 
Gln Ser Lys His Met Lys Gln Thr Leu Ser Leu Arg Lys Thr Pro Tyr
                565                 570                 575     
Asn Leu Gly Phe Met Gln Asn Leu Ala Asp Phe Phe Gln Cys Gly Cys
            580                 585                 590         
Phe Gly Leu Val Lys Pro Cys Val Val Asp Trp Thr Ser Gln Tyr Thr
        595                 600                 605             
Met Val Phe His Pro Ala Arg Glu Lys Val Leu Arg Ser Val
    610                 615                 620         


<210> 9307
<211> 1522
<212> PRT
<213> Homo sapiens

<400> 9307
Met Lys Ala Val Arg Asn Leu Leu Ile Tyr Ile Phe Ser Thr Tyr Leu
 1               5                  10                  15      
Leu Val Met Phe Gly Phe Asn Ala Ala Gln Asp Phe Trp Cys Ser Thr
            20                  25                  30          
Leu Val Lys Gly Val Ile Tyr Gly Ser Tyr Ser Val Ser Glu Met Phe
        35                  40                  45              
Pro Lys Asn Phe Thr Asn Cys Thr Trp Thr Leu Glu Asn Pro Asp Pro
    50                  55                  60                  
Thr Lys Tyr Ser Ile Tyr Leu Lys Phe Ser Lys Lys Asp Leu Ser Cys
65                  70                  75                  80  
Ser Asn Phe Ser Leu Leu Ala Tyr Gln Phe Asp His Phe Ser His Glu
                85                  90                  95      
Lys Ile Lys Asp Leu Leu Arg Lys Asn His Ser Ile Met Gln Leu Cys
            100                 105                 110         
Asn Ser Lys Asn Ala Phe Val Phe Leu Gln Tyr Asp Lys Asn Phe Ile
        115                 120                 125             
Gln Ile Arg Arg Val Phe Pro Thr Asn Phe Pro Gly Leu Gln Lys Lys
    130                 135                 140                 
Gly Glu Glu Asp Gln Lys Ser Phe Phe Glu Phe Leu Val Leu Asn Lys
145                 150                 155                 160 
Val Ser Pro Ser Gln Phe Gly Cys His Val Leu Cys Thr Trp Leu Glu
                165                 170                 175     
Ser Cys Leu Lys Ser Glu Asn Gly Arg Thr Glu Ser Cys Gly Ile Met
            180                 185                 190         
Tyr Thr Lys Cys Thr Cys Pro Gln His Leu Gly Glu Trp Gly Ile Asp
        195                 200                 205             
Asp Gln Ser Leu Ile Leu Leu Asn Asn Val Val Leu Pro Leu Asn Glu
    210                 215                 220                 
Gln Thr Glu Gly Cys Leu Thr Gln Glu Leu Gln Thr Thr Gln Val Cys
225                 230                 235                 240 
Asn Leu Thr Arg Glu Ala Lys Arg Pro Pro Lys Glu Glu Phe Gly Met
                245                 250                 255     
Met Gly Asp His Thr Ile Lys Ser Gln Arg Pro Arg Ser Val His Glu
            260                 265                 270         
Lys Arg Val Pro Gln Glu Gln Ala Asp Ala Ala Lys Phe Met Ala Gln
        275                 280                 285             
Thr Gly Glu Ser Gly Val Glu Glu Trp Ser Gln Trp Ser Thr Cys Ser
    290                 295                 300                 
Val Thr Cys Gly Gln Gly Ser Gln Val Arg Thr Arg Thr Cys Val Ser
305                 310                 315                 320 
Pro Tyr Gly Thr His Cys Ser Gly Pro Leu Arg Glu Ser Arg Val Cys
                325                 330                 335     
Asn Asn Thr Ala Leu Cys Pro Val His Gly Val Trp Glu Glu Trp Ser
            340                 345                 350         
Pro Trp Ser Leu Cys Ser Phe Thr Cys Gly Arg Gly Gln Arg Thr Arg
        355                 360                 365             
Thr Arg Ser Cys Thr Pro Pro Gln Tyr Gly Gly Arg Pro Cys Glu Gly
    370                 375                 380                 
Pro Glu Thr His His Lys Pro Cys Asn Ile Ala Leu Cys Pro Val Asp
385                 390                 395                 400 
Gly Gln Trp Gln Glu Trp Ser Ser Trp Ser Gln Cys Ser Val Thr Cys
                405                 410                 415     
Ser Asn Gly Thr Gln Gln Arg Ser Arg Gln Cys Thr Ala Ala Ala His
            420                 425                 430         
Gly Gly Ser Glu Cys Arg Gly Pro Trp Ala Glu Ser Arg Glu Cys Tyr
        435                 440                 445             
Asn Pro Glu Cys Thr Ala Asn Gly Gln Trp Asn Gln Trp Gly His Trp
    450                 455                 460                 
Ser Gly Cys Ser Lys Ser Cys Asp Gly Gly Trp Glu Arg Arg Ile Arg
465                 470                 475                 480 
Thr Cys Gln Gly Ala Val Ile Thr Gly Gln Gln Cys Glu Gly Thr Gly
                485                 490                 495     
Glu Glu Val Arg Arg Cys Ser Glu Gln Arg Cys Pro Ala Pro Tyr Glu
            500                 505                 510         
Ile Cys Pro Glu Asp Tyr Leu Met Ser Met Val Trp Lys Arg Thr Pro
        515                 520                 525             
Ala Gly Asp Leu Ala Phe Asn Gln Cys Pro Leu Asn Ala Thr Gly Thr
    530                 535                 540                 
Thr Ser Arg Arg Cys Ser Leu Ser Leu His Gly Val Ala Phe Trp Glu
545                 550                 555                 560 
Gln Pro Ser Phe Ala Arg Cys Ile Ser Asn Glu Tyr Arg His Leu Gln
                565                 570                 575     
His Ser Ile Lys Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly
            580                 585                 590         
Asp Gly Met Ser Gln Val Thr Lys Thr Leu Leu Asp Leu Thr Gln Arg
        595                 600                 605             
Lys Asn Phe Tyr Ala Gly Asp Leu Leu Met Ser Val Glu Ile Leu Arg
    610                 615                 620                 
Asn Val Thr Asp Thr Phe Lys Arg Ala Ser Tyr Ile Pro Ala Ser Asp
625                 630                 635                 640 
Gly Val Gln Asn Phe Phe Gln Ile Val Ser Asn Leu Leu Asp Glu Glu
                645                 650                 655     
Asn Lys Glu Lys Trp Glu Asp Ala Gln Gln Ile Tyr Pro Gly Ser Ile
            660                 665                 670         
Glu Leu Met Gln Val Ile Glu Asp Phe Ile His Ile Val Gly Met Gly
        675                 680                 685             
Met Met Asp Phe Gln Asn Ser Tyr Leu Met Thr Gly Asn Val Val Ala
    690                 695                 700                 
Ser Ile Gln Lys Leu Pro Ala Ala Ser Val Leu Thr Asp Ile Asn Phe
705                 710                 715                 720 
Pro Met Lys Gly Arg Lys Gly Met Val Asp Trp Ala Arg Asn Ser Glu
                725                 730                 735     
Asp Arg Val Val Ile Pro Lys Ser Ile Phe Thr Pro Val Ser Ser Lys
            740                 745                 750         
Glu Leu Asp Glu Ser Ser Val Phe Val Leu Gly Ala Val Leu Tyr Lys
        755                 760                 765             
Asn Leu Asp Leu Ile Leu Pro Thr Leu Arg Asn Tyr Thr Val Ile Asn
    770                 775                 780                 
Ser Lys Ile Ile Val Val Thr Ile Arg Pro Glu Pro Lys Thr Thr Asp
785                 790                 795                 800 
Ser Phe Leu Glu Ile Glu Leu Ala His Leu Ala Asn Gly Thr Leu Asn
                805                 810                 815     
Pro Tyr Cys Val Leu Trp Asp Asp Ser Lys Thr Asn Glu Ser Leu Gly
            820                 825                 830         
Thr Trp Ser Thr Gln Gly Cys Lys Thr Val Leu Thr Asp Ala Ser His
        835                 840                 845             
Thr Lys Cys Leu Cys Asp Arg Leu Ser Thr Phe Ala Ile Leu Ala Gln
    850                 855                 860                 
Gln Pro Arg Glu Ile Ile Met Glu Ser Ser Gly Thr Pro Ser Val Thr
865                 870                 875                 880 
Leu Ile Val Gly Ser Gly Leu Ser Cys Leu Ala Leu Ile Thr Leu Ala
                885                 890                 895     
Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile
            900                 905                 910         
Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile
        915                 920                 925             
Leu Val Gly Gln Thr Gln Thr His Asn Lys Ser Ile Cys Thr Thr Thr
    930                 935                 940                 
Thr Ala Phe Leu His Phe Phe Phe Leu Ala Ser Phe Cys Trp Val Leu
945                 950                 955                 960 
Thr Glu Ala Trp Gln Ser Tyr Met Ala Val Thr Gly Lys Ile Arg Thr
                965                 970                 975     
Arg Leu Ile Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly Leu Pro Ala
            980                 985                 990         
Leu Val Val Ala Thr Ser Val Gly Phe Thr Arg Thr Lys Gly Tyr Gly
        995                 1000                1005            
Thr Asp His Tyr Cys Trp Leu Ser Leu Glu Gly Gly Leu Leu Tyr Ala
    1010                1015                1020                
Phe Val Gly Pro Ala Ala Ala Val Val Leu Val Asn Met Val Ile Gly
1025                1030                1035                1040
Ile Leu Val Phe Asn Lys Leu Val Ser Arg Asp Gly Ile Leu Asp Lys
                1045                1050                1055    
Lys Leu Lys His Arg Ala Gly Gln Met Ser Glu Pro His Ser Gly Leu
            1060                1065                1070        
Thr Leu Lys Cys Ala Lys Cys Gly Val Val Ser Thr Thr Ala Leu Ser
        1075                1080                1085            
Ala Thr Thr Ala Ser Asn Ala Met Ala Ser Leu Trp Ser Ser Cys Val
    1090                1095                1100                
Val Leu Pro Leu Leu Ala Leu Thr Trp Met Ser Ala Val Leu Ala Met
1105                1110                1115                1120
Thr Asp Lys Arg Ser Ile Leu Phe Gln Ile Leu Phe Ala Val Phe Asp
                1125                1130                1135    
Ser Leu Gln Gly Phe Val Ile Val Met Val His Cys Ile Leu Arg Arg
            1140                1145                1150        
Glu Val Gln Asp Ala Phe Arg Cys Arg Leu Arg Asn Cys Gln Asp Pro
        1155                1160                1165            
Ile Asn Ala Asp Ser Ser Ser Ser Phe Pro Asn Gly His Ala Gln Ile
    1170                1175                1180                
Met Thr Asp Phe Glu Lys Asp Val Asp Ile Ala Cys Arg Ser Val Leu
1185                1190                1195                1200
His Lys Asp Ile Gly Pro Cys Arg Ala Ala Thr Ile Thr Gly Thr Leu
                1205                1210                1215    
Ser Arg Ile Ser Leu Asn Asp Asp Glu Glu Glu Lys Gly Thr Asn Pro
            1220                1225                1230        
Glu Gly Leu Ser Tyr Ser Thr Leu Pro Gly Asn Val Ile Ser Lys Val
        1235                1240                1245            
Ile Ile Gln Gln Pro Thr Gly Leu His Met Pro Met Ser Met Asn Glu
    1250                1255                1260                
Leu Ser Asn Pro Cys Leu Lys Lys Glu Asn Ser Glu Leu Arg Arg Thr
1265                1270                1275                1280
Val Tyr Leu Cys Thr Asp Asp Asn Leu Arg Gly Ala Asp Met Asp Ile
                1285                1290                1295    
Val His Pro Gln Glu Arg Met Met Glu Ser Asp Tyr Ile Val Met Pro
            1300                1305                1310        
Arg Ser Ser Val Asn Asn Gln Pro Ser Met Lys Glu Glu Ser Lys Met
        1315                1320                1325            
Asn Ile Gly Met Glu Thr Leu Pro His Glu Arg Leu Leu His Tyr Lys
    1330                1335                1340                
Val Asn Pro Glu Phe Asn Met Asn Pro Pro Val Met Asp Gln Phe Asn
1345                1350                1355                1360
Met Asn Leu Glu Gln His Leu Ala Pro Gln Glu His Met Gln Asn Leu
                1365                1370                1375    
Pro Phe Glu Pro Arg Thr Ala Val Lys Asn Phe Met Ala Ser Glu Leu
            1380                1385                1390        
Asp Asp Asn Ala Gly Leu Ser Arg Ser Glu Thr Gly Ser Thr Ile Ser
        1395                1400                1405            
Met Ser Ser Leu Glu Arg Arg Lys Ser Arg Tyr Ser Asp Leu Asp Phe
    1410                1415                1420                
Glu Lys Val Met His Thr Arg Lys Arg His Met Glu Leu Phe Gln Glu
1425                1430                1435                1440
Leu Asn Gln Lys Phe Gln Thr Leu Asp Arg Phe Arg Asp Ile Pro Asn
                1445                1450                1455    
Thr Ser Ser Met Glu Asn Pro Ala Pro Asn Lys Asn Pro Trp Asp Thr
            1460                1465                1470        
Phe Lys Asn Pro Ser Glu Tyr Pro His Tyr Thr Thr Ile Asn Val Leu
        1475                1480                1485            
Asp Thr Glu Ala Lys Asp Ala Leu Glu Leu Arg Pro Ala Glu Trp Glu
    1490                1495                1500                
Lys Cys Leu Asn Leu Pro Leu Asp Val Gln Glu Gly Asp Phe Gln Thr
1505                1510                1515                1520
Glu Val
        


<210> 9308
<211> 765
<212> PRT
<213> Homo sapiens

<400> 9308
Met Asn Thr Ser Gly Asp Pro Ala Gln Thr Gly Pro Glu Gly Cys Arg
 1               5                  10                  15      
Gly Thr Met Ser Ala Glu Glu Asp Ala Arg Trp Leu Arg Trp Val Thr
            20                  25                  30          
Gln Gln Phe Lys Thr Ile Ala Gly Glu Asp Gly Glu Ile Ser Leu Gln
        35                  40                  45              
Glu Phe Lys Ala Ala Leu His Val Lys Glu Ser Phe Phe Ala Glu Arg
    50                  55                  60                  
Phe Phe Ala Leu Phe Asp Ser Asp Arg Ser Gly Thr Ile Thr Leu Gln
65                  70                  75                  80  
Glu Leu Gln Glu Ala Leu Thr Leu Leu Ile His Gly Ser Pro Met Asp
                85                  90                  95      
Lys Leu Lys Phe Leu Phe Gln Val Tyr Asp Ile Asp Val Cys Ala Arg
            100                 105                 110         
Gln Gly Ala Ser Ala Gly Thr Glu Trp Gly Ala Gly Ala Gly Pro His
        115                 120                 125             
Trp Ala Ser Ser Pro Leu Gly Thr Gly Ser Gly Ser Ile Asp Pro Asp
    130                 135                 140                 
Glu Leu Arg Thr Val Leu Gln Ser Cys Leu Arg Glu Ser Ala Ile Ser
145                 150                 155                 160 
Leu Pro Asp Glu Lys Leu Asp Gln Leu Thr Leu Ala Leu Phe Glu Ser
                165                 170                 175     
Ala Asp Ala Asp Gly Asn Gly Ala Ile Thr Phe Glu Glu Leu Arg Asp
            180                 185                 190         
Glu Leu Gln Arg Phe Pro Gly Val Met Glu Asn Leu Thr Ile Ser Ala
        195                 200                 205             
Ala His Trp Leu Thr Ala Pro Ala Pro Arg Pro Arg Pro Arg Arg Pro
    210                 215                 220                 
Arg Gln Leu Thr Arg Ala Tyr Trp His Asn His Arg Ser Gln Leu Phe
225                 230                 235                 240 
Cys Leu Ala Thr Tyr Ala Gly Leu His Val Leu Leu Phe Gly Leu Ala
                245                 250                 255     
Ala Ser Ala His Arg Asp Leu Gly Ala Ser Val Met Val Ala Lys Gly
            260                 265                 270         
Cys Gly Gln Cys Leu Asn Phe Asp Cys Ser Phe Ile Ala Val Leu Met
        275                 280                 285             
Leu Arg Arg Cys Leu Thr Trp Leu Arg Ala Thr Trp Leu Ala Gln Val
    290                 295                 300                 
Leu Pro Leu Asp Gln Asn Ile Gln Phe His Gln Leu Met Gly Tyr Val
305                 310                 315                 320 
Val Val Gly Leu Ser Leu Val His Thr Val Ala His Thr Val Asn Phe
                325                 330                 335     
Val Leu Gln Ala Gln Ala Glu Ala Ser Pro Phe Gln Phe Trp Glu Leu
            340                 345                 350         
Leu Leu Thr Thr Arg Pro Gly Ile Gly Trp Val His Gly Ser Ala Ser
        355                 360                 365             
Pro Thr Gly Val Ala Leu Leu Leu Leu Leu Leu Leu Met Phe Ile Cys
    370                 375                 380                 
Ser Ser Ser Cys Ile Arg Arg Ser Gly His Phe Glu Val Phe Tyr Trp
385                 390                 395                 400 
Thr His Leu Ser Tyr Leu Leu Val Trp Leu Leu Leu Ile Phe His Gly
                405                 410                 415     
Pro Asn Phe Trp Lys Trp Leu Leu Val Pro Gly Ile Leu Phe Phe Leu
            420                 425                 430         
Glu Lys Ala Ile Gly Leu Ala Val Ser Arg Met Ala Ala Val Cys Ile
        435                 440                 445             
Met Glu Val Asn Leu Leu Pro Ser Lys Val Thr His Leu Leu Ile Lys
    450                 455                 460                 
Arg Pro Pro Phe Phe His Tyr Arg Pro Gly Asp Tyr Leu Tyr Leu Asn
465                 470                 475                 480 
Ile Pro Thr Ile Ala Arg Tyr Glu Trp His Pro Phe Thr Ile Ser Ser
                485                 490                 495     
Ala Pro Glu Gln Lys Asp Thr Ile Trp Leu His Ile Arg Ser Gln Gly
            500                 505                 510         
Gln Trp Thr Asn Arg Leu Tyr Glu Ser Phe Lys Ala Ser Asp Pro Leu
        515                 520                 525             
Gly Arg Gly Ser Lys Arg Leu Ser Arg Ser Val Thr Met Arg Lys Ser
    530                 535                 540                 
Gln Arg Ser Ser Lys Gly Ser Glu Ile Leu Leu Glu Lys His Lys Phe
545                 550                 555                 560 
Cys Asn Ile Lys Cys Tyr Ile Asp Gly Pro Tyr Gly Thr Pro Thr Arg
                565                 570                 575     
Arg Ile Phe Ala Ser Glu His Ala Val Leu Ile Gly Ala Gly Ile Gly
            580                 585                 590         
Ile Thr Pro Phe Ala Ser Ile Leu Gln Ser Ile Met Tyr Arg His Gln
        595                 600                 605             
Lys Arg Lys His Thr Cys Pro Ser Cys Gln His Ser Trp Ile Glu Gly
    610                 615                 620                 
Val Gln Asp Asn Met Lys Leu His Lys Val Asp Phe Ile Trp Ile Asn
625                 630                 635                 640 
Arg Asp Gln Arg Ser Phe Glu Trp Phe Val Ser Leu Leu Thr Lys Leu
                645                 650                 655     
Glu Met Asp Gln Ala Glu Glu Ala Gln Tyr Gly Arg Phe Leu Glu Leu
            660                 665                 670         
His Met Tyr Met Thr Ser Ala Leu Gly Lys Asn Asp Met Lys Ala Ile
        675                 680                 685             
Gly Leu Gln Met Ala Leu Asp Leu Leu Ala Asn Lys Glu Lys Lys Asp
    690                 695                 700                 
Ser Ile Thr Gly Leu Gln Thr Arg Thr Gln Pro Gly Arg Pro Asp Trp
705                 710                 715                 720 
Ser Lys Val Phe Gln Lys Val Ala Ala Glu Lys Lys Gly Lys Val Gln
                725                 730                 735     
Val Phe Phe Cys Gly Ser Pro Ala Leu Ala Lys Val Leu Lys Gly His
            740                 745                 750         
Cys Glu Lys Phe Gly Phe Arg Phe Phe Gln Glu Asn Phe
        755                 760                 765 


<210> 9309
<211> 683
<212> PRT
<213> Homo sapiens

<400> 9309
Met Asp Asp Tyr Lys Tyr Gln Asp Asn Tyr Gly Gly Tyr Ala Pro Ser
 1               5                  10                  15      
Asp Gly Tyr Tyr Arg Gly Asn Glu Ser Asn Pro Glu Glu Asp Ala Gln
            20                  25                  30          
Ser Asp Val Thr Glu Gly His Asp Glu Glu Asp Glu Ile Tyr Glu Gly
        35                  40                  45              
Glu Tyr Gln Gly Ile Pro His Pro Asp Asp Val Lys Ala Lys Gln Ala
    50                  55                  60                  
Lys Met Ala Pro Ser Arg Met Asp Ser Leu Arg Gly Gln Thr Asp Leu
65                  70                  75                  80  
Met Ala Glu Arg Leu Glu Asp Glu Glu Gln Leu Ala His Gln Tyr Glu
                85                  90                  95      
Thr Ile Met Asp Glu Cys Gly His Gly Arg Phe Gln Trp Ile Leu Phe
            100                 105                 110         
Phe Val Leu Gly Leu Ala Leu Met Ala Asp Gly Val Glu Val Phe Val
        115                 120                 125             
Val Ser Phe Ala Leu Pro Ser Ala Glu Lys Asp Met Cys Leu Ser Ser
    130                 135                 140                 
Ser Lys Lys Gly Met Leu Gly Met Ile Val Tyr Leu Gly Met Met Ala
145                 150                 155                 160 
Gly Ala Phe Ile Leu Gly Gly Leu Ala Asp Lys Leu Gly Arg Lys Arg
                165                 170                 175     
Val Leu Ser Met Ser Leu Ala Val Asn Ala Ser Phe Ala Ser Leu Ser
            180                 185                 190         
Ser Phe Val Gln Gly Tyr Gly Ala Phe Leu Phe Cys Arg Leu Ile Ser
        195                 200                 205             
Gly Ile Gly Ile Gly Gly Ala Leu Pro Ile Val Phe Ala Tyr Phe Ser
    210                 215                 220                 
Glu Phe Leu Ser Arg Glu Lys Arg Gly Glu His Leu Ser Trp Leu Gly
225                 230                 235                 240 
Ile Phe Trp Met Thr Gly Gly Leu Tyr Ala Ser Ala Met Ala Trp Ser
                245                 250                 255     
Ile Ile Pro His Tyr Gly Trp Gly Phe Ser Met Gly Thr Asn Tyr His
            260                 265                 270         
Phe His Ser Trp Arg Val Phe Val Ile Val Cys Ala Leu Pro Cys Thr
        275                 280                 285             
Val Ser Met Val Ala Leu Lys Phe Met Pro Glu Ser Pro Arg Phe Leu
    290                 295                 300                 
Leu Glu Met Gly Lys His Asp Glu Ala Trp Met Ile Leu Lys Gln Val
305                 310                 315                 320 
His Asp Thr Asn Met Arg Ala Lys Gly Thr Pro Glu Lys Val Phe Thr
                325                 330                 335     
Val Ser Asn Ile Lys Thr Pro Lys Gln Met Asp Glu Phe Ile Glu Ile
            340                 345                 350         
Gln Ser Ser Thr Gly Thr Trp Tyr Gln Arg Trp Leu Val Arg Phe Lys
        355                 360                 365             
Thr Ile Phe Lys Gln Val Trp Asp Asn Ala Leu Tyr Cys Val Met Gly
    370                 375                 380                 
Pro Tyr Arg Met Asn Thr Leu Ile Leu Ala Val Val Trp Phe Ala Met
385                 390                 395                 400 
Ala Phe Ser Tyr Tyr Gly Leu Thr Val Trp Phe Pro Asp Met Ile Arg
                405                 410                 415     
Tyr Phe Gln Asp Glu Glu Tyr Lys Ser Lys Met Lys Val Phe Phe Gly
            420                 425                 430         
Glu His Val Tyr Gly Ala Thr Ile Asn Phe Thr Met Glu Asn Gln Ile
        435                 440                 445             
His Gln His Gly Lys Leu Val Asn Asp Lys Phe Thr Arg Met Tyr Phe
    450                 455                 460                 
Lys His Val Leu Phe Glu Asp Thr Phe Phe Asp Glu Cys Tyr Phe Glu
465                 470                 475                 480 
Asp Val Thr Ser Thr Asp Thr Tyr Phe Lys Asn Cys Thr Ile Glu Ser
                485                 490                 495     
Thr Ile Phe Tyr Asn Thr Asp Leu Tyr Glu His Lys Phe Ile Asn Cys
            500                 505                 510         
Arg Phe Ile Asn Ser Thr Phe Leu Glu Gln Lys Glu Gly Cys His Met
        515                 520                 525             
Asp Leu Glu Gln Asp Asn Asp Phe Leu Ile Tyr Leu Val Ser Phe Leu
    530                 535                 540                 
Gly Ser Leu Ser Val Leu Pro Gly Asn Ile Ile Ser Ala Leu Leu Met
545                 550                 555                 560 
Asp Arg Ile Gly Arg Leu Lys Met Ile Gly Gly Ser Met Leu Ile Ser
                565                 570                 575     
Ala Val Cys Cys Phe Phe Leu Phe Phe Gly Asn Ser Glu Ser Ala Met
            580                 585                 590         
Ile Gly Trp Gln Cys Leu Phe Cys Gly Thr Ser Ile Ala Ala Trp Asn
        595                 600                 605             
Ala Leu Asp Val Ile Thr Val Glu Leu Tyr Pro Thr Asn Gln Arg Ala
    610                 615                 620                 
Thr Ala Phe Gly Ile Leu Asn Gly Leu Cys Lys Phe Gly Ala Ile Leu
625                 630                 635                 640 
Gly Asn Thr Ile Phe Ala Ser Phe Val Gly Ile Thr Lys Val Val Pro
                645                 650                 655     
Ile Leu Leu Ala Ala Ala Ser Leu Val Gly Gly Gly Leu Ile Ala Leu
            660                 665                 670         
Arg Leu Pro Glu Thr Arg Glu Gln Val Leu Met
        675                 680             


<210> 9310
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 9310
Met Pro Lys Gly Gly Ala Pro Pro Trp Ile Met Ala Leu Met Phe Thr
 1               5                  10                  15      
Gly His Leu Leu Phe Leu Ala Leu Leu Met Phe Ala Phe Ser Thr Phe
            20                  25                  30          
Glu Glu Ser Val Ser Asn Tyr Ser Glu Trp Ala Val Phe Thr Asp Asp
        35                  40                  45              
Ile Asp Gln Phe Lys Thr Gln Lys Val Gln Asp Phe Arg Pro Asn Gln
    50                  55                  60                  
Lys Leu Lys Lys Ser Met Leu His Pro Ser Leu Tyr Phe Asp Ala Gly
65                  70                  75                  80  
Glu Ile Gln Ala Met Arg Gln Lys Ser Arg Ala Ser His Leu His Leu
                85                  90                  95      
Phe Arg Ala Ile Arg Ser Ala Val Thr Val Met Leu Ser Asn Pro Thr
            100                 105                 110         
Tyr Tyr Leu Pro Pro Pro Lys His Ala Asp Phe Ala Ala Lys Trp Asn
        115                 120                 125             
Glu Ile Tyr Gly Asn Asn Leu Pro Pro Leu Ala Leu Tyr Cys Leu Leu
    130                 135                 140                 
Cys Pro Glu Asp Lys Val Ala Phe Glu Phe Val Leu Glu Tyr Met Asp
145                 150                 155                 160 
Arg Met Val Gly Tyr Lys Asp Trp Leu Val Glu Asn Ala Pro Gly Asp
                165                 170                 175     
Glu Val Pro Ile Gly His Ser Leu Thr Gly Phe Ala Thr Ala Phe Asp
            180                 185                 190         
Phe Leu Tyr Asn Leu Leu Asp Asn His Arg Arg Gln Lys Tyr Leu Glu
        195                 200                 205             
Lys Ile Trp Val Ile Thr Glu Glu Met Tyr Glu Tyr Ser Lys Val Arg
    210                 215                 220                 
Ser Trp Gly Lys Gln Leu Leu His Asn His Gln Ala Thr Asn Met Ile
225                 230                 235                 240 
Ala Leu Leu Thr Gly Ala Leu Val Thr Gly Val Asp Lys Gly Ser Lys
                245                 250                 255     
Ala Asn Ile Trp Lys Gln Ala Val Val Asp Val Met Glu Lys Thr Met
            260                 265                 270         
Phe Leu Leu Asn His Ile Val Asp Gly Ser Leu Asp Glu Gly Val Ala
        275                 280                 285             
Tyr Gly Ser Tyr Thr Ala Lys Ser Val Thr Gln Tyr Val Phe Leu Ala
    290                 295                 300                 
Gln Arg His Phe Asn Ile Asn Asn Leu Asp Asn Asn Trp Leu Lys Met
305                 310                 315                 320 
His Phe Trp Phe Tyr Tyr Ala Thr Leu Leu Pro Gly Phe Gln Arg Thr
                325                 330                 335     
Val Gly Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr Gly Pro Glu Ser
            340                 345                 350         
Gln Leu Val Phe Leu Asp Lys Phe Ile Leu Lys Asn Gly Ala Gly Asn
        355                 360                 365             
Trp Leu Ala Gln Gln Ile Arg Lys His Arg Pro Lys Asp Gly Pro Met
    370                 375                 380                 
Val Pro Ser Thr Ala Gln Arg Trp Ser Thr Leu His Thr Glu Tyr Ile
385                 390                 395                 400 
Trp Tyr Asp Pro Gln Leu Thr Pro Gln Pro Pro Ala Asp Tyr Gly Thr
                405                 410                 415     
Ala Lys Ile His Thr Phe Pro Asn Trp Gly Val Val Thr Tyr Gly Ala
            420                 425                 430         
Gly Leu Pro Asn Thr Gln Thr Asn Thr Phe Val Ser Phe Lys Ser Gly
        435                 440                 445             
Lys Leu Gly Gly Arg Ala Val Tyr Asp Ile Val His Phe Gln Pro Tyr
    450                 455                 460                 
Ser Trp Ile Asp Gly Trp Arg Ser Phe Asn Pro Gly His Glu His Pro
465                 470                 475                 480 
Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly Gln Val Phe Val Ser
                485                 490                 495     
Glu Ala Leu Tyr Gly Pro Lys Leu Ser His Leu Asn Asn Val Leu Val
            500                 505                 510         
Phe Ala Pro Ser Pro Ser Ser Gln Cys Asn Lys Pro Trp Glu Gly Gln
        515                 520                 525             
Leu Gly Glu Cys Ala Gln Trp Leu Lys Trp Thr Gly Glu Glu Val Gly
    530                 535                 540                 
Asp Ala Ala Gly Glu Ile Ile Thr Ala Ser Gln His Gly Glu Met Val
545                 550                 555                 560 
Phe Val Ser Gly Glu Ala Val Ser Ala Tyr Ser Ser Ala Met Arg Leu
                565                 570                 575     
Lys Ser Val Tyr Arg Ala Leu Leu Leu Leu Asn Ser Gln Thr Leu Leu
            580                 585                 590         
Val Val Asp His Ile Glu Arg Gln Glu Asp Ser Pro Ile Asn Ser Val
        595                 600                 605             
Ser Ala Phe Phe His Asn Leu Asp Ile Asp Phe Lys Tyr Ile Pro Tyr
    610                 615                 620                 
Lys Phe Met Asn Arg Tyr Asn Gly Ala Met Met Asp Val Trp Asp Ala
625                 630                 635                 640 
His Tyr Lys Met Phe Trp Phe Asp His His Gly Asn Ser Pro Met Ala
                645                 650                 655     
Ser Ile Gln Glu Ala Glu Gln Ala Ala Glu Phe Lys Lys Arg Trp Thr
            660                 665                 670         
Gln Phe Val Asn Val Thr Phe Gln Met Glu Pro Thr Ile Thr Arg Ile
        675                 680                 685             
Ala Tyr Val Phe Tyr Gly Pro Tyr Ile Asn Val Ser Ser Cys Arg Phe
    690                 695                 700                 
Ile Asp Ser Ser Asn Pro Gly Leu Gln Ile Ser Leu Asn Val Asn Asn
705                 710                 715                 720 
Thr Glu His Val Val Ser Ile Val Thr Asp Tyr His Asn Leu Lys Thr
                725                 730                 735     
Arg Phe Asn Tyr Leu Gly Phe Gly Gly Phe Ala Ser Val Ala Asp Gln
            740                 745                 750         
Gly Gln Ile Thr Arg Phe Gly Leu Gly Thr Gln Ala Ile Val Lys Pro
        755                 760                 765             
Val Arg His Asp Arg Ile Ile Phe Pro Phe Gly Phe Lys Phe Asn Ile
    770                 775                 780                 
Ala Val Gly Leu Ile Leu Cys Ile Ser Leu Val Ile Leu Thr Phe Gln
785                 790                 795                 800 
Trp Arg Phe Tyr Leu Ser Phe Arg Lys Leu Met Arg Trp Ile Leu Ile
                805                 810                 815     
Leu Val Ile Ala Leu Trp Phe Ile Glu Leu Leu Asp Val Trp Ser Thr
            820                 825                 830         
Cys Ser Gln Pro Ile Cys Ala Lys Trp Thr Arg Thr Glu Ala Glu Gly
        835                 840                 845             
Ser Lys Lys Ser Leu Ser Ser Glu Gly His His Met Asp Leu Pro Asp
    850                 855                 860                 
Val Val Ile Thr Ser Leu Pro Gly Ser Gly Ala Glu Ile Leu Lys Gln
865                 870                 875                 880 
Leu Phe Phe Asn Ser Ser Asp Phe Leu Tyr Ile Arg Val Pro Thr Ala
                885                 890                 895     
Tyr Ile Asp Ile Pro Glu Thr Glu Leu Glu Ile Asp Ser Phe Val Asp
            900                 905                 910         
Ala Cys Glu Trp Lys Val Ser Asp Ile Arg Ser Gly His Phe Arg Leu
        915                 920                 925             
Leu Arg Gly Trp Leu Gln Ser Leu Val Gln Asp Thr Lys Leu His Leu
    930                 935                 940                 
Gln Asn Ile His Leu His Glu Pro Asn Arg Gly Lys Leu Ala Gln Tyr
945                 950                 955                 960 
Phe Ala Met Asn Lys Asp Lys Lys Arg Lys Phe Lys Arg Arg Glu Ser
                965                 970                 975     
Leu Pro Glu Gln Arg Ser Gln Met Lys Gly Ala Phe Asp Arg Asp Ala
            980                 985                 990         
Glu Tyr Ile Arg Ala Leu Arg Arg His Leu Val Tyr Tyr Pro Ser Ala
        995                 1000                1005            
Arg Pro Val Leu Ser Leu Ser Ser Gly Ser Trp Thr Leu Lys Leu His
    1010                1015                1020                
Phe Phe Gln Glu Val Leu Gly Ala Ser Met Arg Ala Leu Tyr Ile Val
1025                1030                1035                1040
Arg Asp Pro Arg Ala Trp Ile Tyr Ser Met Leu Tyr Asn Ser Lys Pro
                1045                1050                1055    
Ser Leu Tyr Ser Leu Lys Asn Val Pro Glu His Leu Ala Lys Leu Phe
            1060                1065                1070        
Lys Ile Glu Gly Gly Lys Gly Lys Cys Asn Leu Asn Ser Gly Tyr Ala
        1075                1080                1085            
Phe Glu Tyr Glu Pro Leu Arg Lys Glu Leu Ser Lys Ser Lys Ser Asn
    1090                1095                1100                
Ala Val Ser Leu Leu Ser His Leu Trp Leu Ala Asn Thr Ala Ala Ala
1105                1110                1115                1120
Leu Arg Ile Asn Thr Asp Leu Leu Pro Thr Ser Tyr Gln Leu Val Lys
                1125                1130                1135    
Phe Glu Asp Ile Val His Phe Pro Gln Lys Thr Thr Glu Arg Ile Phe
            1140                1145                1150        
Ala Phe Leu Gly Ile Pro Leu Ser Pro Ala Ser Leu Asn Gln Ile Leu
        1155                1160                1165            
Phe Ala Thr Ser Thr Asn Leu Phe Tyr Leu Pro Tyr Glu Gly Glu Ile
    1170                1175                1180                
Ser Pro Thr Asn Thr Asn Val Trp Lys Gln Asn Leu Pro Arg Asp Glu
1185                1190                1195                1200
Ile Lys Leu Ile Glu Asn Ile Cys Trp Thr Leu Met Asp Arg Leu Gly
                1205                1210                1215    
Tyr Pro Lys Phe Met Asp
            1220        


<210> 9311
<211> 216
<212> PRT
<213> Homo sapiens

<400> 9311
Met Lys Val Asp Arg Thr Lys Leu Lys Lys Thr Pro Thr Glu Ala Pro
 1               5                  10                  15      
Ala Asp Cys Arg Ala Leu Ile Asp Lys Leu Lys Val Cys Asn Asp Glu
            20                  25                  30          
Gln Leu Leu Leu Glu Leu Gln Gln Ile Lys Thr Trp Asn Ile Gly Lys
        35                  40                  45              
Cys Glu Leu Tyr His Trp Val Asp Leu Leu Asp Arg Phe Asp Gly Ile
    50                  55                  60                  
Leu Ala Asp Ala Gly Gln Thr Val Glu Asn Met Ser Trp Met Leu Val
65                  70                  75                  80  
Cys Asp Arg Pro Glu Arg Glu Gln Leu Lys Met Leu Leu Leu Ala Val
                85                  90                  95      
Leu Asn Phe Thr Ala Leu Leu Ile Glu Tyr Ser Phe Ser Arg His Leu
            100                 105                 110         
Tyr Ser Ser Ile Glu His Leu Thr Thr Leu Leu Ala Ser Ser Asp Met
        115                 120                 125             
Gln Val Val Leu Ala Val Leu Asn Leu Leu Tyr Val Phe Ser Lys Arg
    130                 135                 140                 
Ser Asn Tyr Ile Thr Arg Leu Gly Ser Asp Lys Arg Thr Pro Leu Leu
145                 150                 155                 160 
Thr Arg Leu Gln His Leu Ala Glu Ser Trp Gly Gly Lys Glu Asn Gly
                165                 170                 175     
Phe Gly Leu Ala Glu Cys Cys Arg Asp Leu His Met Met Lys Tyr Pro
            180                 185                 190         
Pro Ser Ala Thr Thr Leu His Phe Glu Phe Tyr Ala Asp Pro Gly Ala
        195                 200                 205             
Glu Val Lys Lys Lys Lys Lys Lys
    210                 215     


<210> 9312
<211> 750
<212> PRT
<213> Homo sapiens

<400> 9312
Ala Glu Gly Phe Gly Asp Ala Glu Gly Gly Arg Val Trp Ala Ala Arg
 1               5                  10                  15      
Glu Pro Gln Gly Ala Leu Ala Phe Ala Glu Thr Met Ala Glu Glu Glu
            20                  25                  30          
Gly Pro Pro Val Glu Leu Arg Gln Arg Lys Lys Pro Lys Ser Ser Glu
        35                  40                  45              
Asn Lys Glu Ser Ala Lys Glu Glu Lys Ile Ser Asp Ile Pro Ile Pro
    50                  55                  60                  
Glu Arg Ala Pro Lys His Val Leu Phe Gln Arg Phe Ala Lys Ile Phe
65                  70                  75                  80  
Ile Gly Cys Leu Ala Ala Val Thr Ser Gly Met Met Tyr Ala Leu Tyr
                85                  90                  95      
Leu Ser Ala Tyr His Glu Arg Lys Phe Trp Phe Ser Asn Arg Gln Glu
            100                 105                 110         
Leu Glu Arg Glu Ile Thr Phe Gln Gly Asp Ser Ala Ile Tyr Tyr Ser
        115                 120                 125             
Tyr Tyr Lys Asp Met Leu Lys Ala Pro Ser Phe Glu Arg Gly Val Tyr
    130                 135                 140                 
Glu Leu Thr His Asn Asn Lys Thr Val Ser Leu Lys Thr Ile Asn Ala
145                 150                 155                 160 
Val Gln Gln Met Ser Leu Tyr Pro Glu Leu Ile Ala Ser Ile Leu Tyr
                165                 170                 175     
Gln Ala Thr Gly Ser Asn Glu Ile Ile Glu Pro Val Tyr Phe Tyr Ile
            180                 185                 190         
Gly Ile Val Phe Gly Leu Gln Gly Ile Tyr Val Thr Ala Leu Phe Val
        195                 200                 205             
Thr Ser Trp Leu Met Ser Gly Thr Trp Leu Ala Gly Met Leu Thr Val
    210                 215                 220                 
Ala Trp Phe Val Ile Asn Arg Val Asp Thr Thr Arg Ile Glu Tyr Ser
225                 230                 235                 240 
Ile Pro Leu Arg Glu Asn Trp Ala Leu Pro Tyr Phe Ala Cys Gln Ile
                245                 250                 255     
Ala Ala Leu Thr Gly Tyr Leu Lys Ser Asn Leu Asn Thr Tyr Gly Glu
            260                 265                 270         
Arg Phe Cys Tyr Leu Leu Met Ser Ala Ser Thr Tyr Thr Phe Met Met
        275                 280                 285             
Met Trp Glu Tyr Ser His Tyr Leu Leu Phe Leu Gln Ala Ile Ser Leu
    290                 295                 300                 
Phe Leu Leu Asp Thr Phe Ser Val Glu Gln Ser Asp Lys Val Tyr Glu
305                 310                 315                 320 
Val Tyr Lys Ile Tyr Ile Phe Ser Leu Phe Leu Gly Tyr Leu Leu Gln
                325                 330                 335     
Phe Glu Asn Pro Ala Leu Leu Val Ser Pro Leu Leu Ser Leu Val Ala
            340                 345                 350         
Ala Leu Met Leu Ala Lys Cys Leu Gln Leu Asn Val Lys Lys Gly Ser
        355                 360                 365             
Phe Val Ala Lys Ile Ile Lys Val Ile Asn Phe Tyr Leu Val Cys Thr
    370                 375                 380                 
Leu Thr Ile Thr Leu Asn Ile Ile Met Lys Met Phe Val Pro His Lys
385                 390                 395                 400 
Glu Asn Gly His Met Leu Lys Phe Leu Glu Val Lys Phe Gly Leu Asn
                405                 410                 415     
Met Thr Lys Asn Phe Thr Met Asn Trp Leu Leu Cys Gln Glu Ser Leu
            420                 425                 430         
Gln Ala Pro Ser Gln Asp Phe Phe Leu Arg Leu Thr Gln Ser Ser Leu
        435                 440                 445             
Leu Pro Phe Tyr Ile Leu Val Leu Ile Ile Cys Phe Leu Ser Met Leu
    450                 455                 460                 
Gln Val Ile Phe Arg Arg Ile Asn Gly Lys Ser Leu Lys Glu Thr Val
465                 470                 475                 480 
Thr Leu Glu Asp Gly Arg Ile Gly Glu Arg Pro Glu Ile Ile Tyr His
                485                 490                 495     
Val Ile His Thr Ile Leu Leu Gly Ser Leu Ala Met Val Ile Glu Gly
            500                 505                 510         
Leu Lys Tyr Ile Trp Ile Pro Tyr Val Cys Met Leu Ala Ala Phe Gly
        515                 520                 525             
Val Cys Ser Pro Glu Leu Trp Met Thr Leu Phe Lys Trp Leu Arg Leu
    530                 535                 540                 
Arg Thr Val His Pro Ile Leu Leu Ala Leu Ile Leu Ser Met Ala Val
545                 550                 555                 560 
Pro Thr Ile Ile Gly Leu Ser Leu Trp Lys Glu Phe Phe Pro Arg Leu
                565                 570                 575     
Met Thr Glu Leu Met Glu Leu Gln Glu Phe Tyr Asp Pro Asp Thr Val
            580                 585                 590         
Glu Leu Met Thr Trp Ile Lys Arg Gln Ala Pro Val Ala Ala Val Phe
        595                 600                 605             
Ala Gly Ser Pro Gln Leu Met Gly Ala Ile Lys Leu Cys Thr Gly Trp
    610                 615                 620                 
Met Val Thr Ser Leu Pro Leu Tyr Asn Asp Asp Asp Leu Leu Lys Arg
625                 630                 635                 640 
Asn Glu Asn Ile Tyr Gln Ile Tyr Ser Lys Arg Ser Ala Glu Asp Ile
                645                 650                 655     
Tyr Lys Ile Leu Thr Ser Tyr Lys Ala Asn Tyr Leu Ile Val Glu Asp
            660                 665                 670         
Ala Ile Cys Asn Glu Val Gly Pro Met Arg Gly Cys Arg Val Lys Asp
        675                 680                 685             
Leu Leu Asp Ile Ala Asn Gly His Met Val Cys Glu Glu Gly Asp Lys
    690                 695                 700                 
Leu Thr Tyr Ser Lys Tyr Gly Arg Phe Cys His Glu Val Lys Ile Asn
705                 710                 715                 720 
Tyr Ser Pro Tyr Val Asn Tyr Phe Thr Arg Val Tyr Trp Asn Arg Ser
                725                 730                 735     
Tyr Phe Val Tyr Lys Ile Asn Thr Val Ile Ser Phe Gln Ser
            740                 745                 750 


<210> 9313
<211> 894
<212> PRT
<213> Homo sapiens

<400> 9313
Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe
 1               5                  10                  15      
Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn
            20                  25                  30          
Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His
        35                  40                  45              
Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr
    50                  55                  60                  
Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser
65                  70                  75                  80  
Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg
                85                  90                  95      
Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr
            100                 105                 110         
Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser
        115                 120                 125             
Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala
    130                 135                 140                 
Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys
145                 150                 155                 160 
Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala
                165                 170                 175     
Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser
            180                 185                 190         
Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu
        195                 200                 205             
Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu
    210                 215                 220                 
Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser
225                 230                 235                 240 
Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu
                245                 250                 255     
Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile
            260                 265                 270         
Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val
        275                 280                 285             
Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys
    290                 295                 300                 
Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala
305                 310                 315                 320 
Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser
                325                 330                 335     
Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile
            340                 345                 350         
Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly
        355                 360                 365             
Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp
    370                 375                 380                 
Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn
385                 390                 395                 400 
Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp
                405                 410                 415     
Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu
            420                 425                 430         
Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn
        435                 440                 445             
Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys
    450                 455                 460                 
His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr
465                 470                 475                 480 
Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu
                485                 490                 495     
Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr
            500                 505                 510         
Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Leu Met Ser Leu
        515                 520                 525             
Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val
    530                 535                 540                 
Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val
545                 550                 555                 560 
Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe
                565                 570                 575     
Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp
            580                 585                 590         
Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser
        595                 600                 605             
Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser
    610                 615                 620                 
Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe
625                 630                 635                 640 
Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu
                645                 650                 655     
Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala
            660                 665                 670         
Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys
        675                 680                 685             
Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser
    690                 695                 700                 
Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp
705                 710                 715                 720 
Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu
                725                 730                 735     
Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr
            740                 745                 750         
Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr
        755                 760                 765             
Pro Lys Gly Ser Ala Leu Gly Thr Pro Val Asn Leu Ala Val Leu Lys
    770                 775                 780                 
Leu Ser Glu Gln Gly Ile Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr
785                 790                 795                 800 
Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly Ser Lys Asp Lys Thr
                805                 810                 815     
Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val
            820                 825                 830         
Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr
        835                 840                 845             
Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln
    850                 855                 860                 
Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr
865                 870                 875                 880 
Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile
                885                 890                 


<210> 9314
<211> 144
<212> PRT
<213> Homo sapiens

<400> 9314
Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe
 1               5                  10                  15      
Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn
            20                  25                  30          
Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His
        35                  40                  45              
Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr
    50                  55                  60                  
Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser
65                  70                  75                  80  
Ser Asn Ser Phe Ser Val Thr Asn Ala Cys Pro Ala Glu Arg Asp Tyr
                85                  90                  95      
Leu Pro Trp Pro Gly Ser Ile Arg Glu Asn Asn Trp Thr Ala Leu Pro
            100                 105                 110         
Cys Cys Lys Asp His Gly Leu Leu His Leu Lys Cys Ser Pro Gly Gly
        115                 120                 125             
Ala Arg Gln Asn Trp Ala Tyr Cys Ile Trp Gly Val Thr Gly Glu Leu
    130                 135                 140                 


<210> 9315
<211> 894
<212> PRT
<213> Homo sapiens

<400> 9315
Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe
 1               5                  10                  15      
Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn
            20                  25                  30          
Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His
        35                  40                  45              
Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr
    50                  55                  60                  
Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser
65                  70                  75                  80  
Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg
                85                  90                  95      
Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr
            100                 105                 110         
Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser
        115                 120                 125             
Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala
    130                 135                 140                 
Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys
145                 150                 155                 160 
Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala
                165                 170                 175     
Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser
            180                 185                 190         
Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu
        195                 200                 205             
Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu
    210                 215                 220                 
Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser
225                 230                 235                 240 
Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu
                245                 250                 255     
Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile
            260                 265                 270         
Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val
        275                 280                 285             
Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys
    290                 295                 300                 
Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala
305                 310                 315                 320 
Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser
                325                 330                 335     
Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile
            340                 345                 350         
Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly
        355                 360                 365             
Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp
    370                 375                 380                 
Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn
385                 390                 395                 400 
Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp
                405                 410                 415     
Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu
            420                 425                 430         
Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn
        435                 440                 445             
Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys
    450                 455                 460                 
His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr
465                 470                 475                 480 
Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu
                485                 490                 495     
Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr
            500                 505                 510         
Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Leu Met Ser Leu
        515                 520                 525             
Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val
    530                 535                 540                 
Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val
545                 550                 555                 560 
Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe
                565                 570                 575     
Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp
            580                 585                 590         
Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser
        595                 600                 605             
Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser
    610                 615                 620                 
Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe
625                 630                 635                 640 
Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu
                645                 650                 655     
Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala
            660                 665                 670         
Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys
        675                 680                 685             
Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser
    690                 695                 700                 
Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp
705                 710                 715                 720 
Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu
                725                 730                 735     
Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr
            740                 745                 750         
Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr
        755                 760                 765             
Pro Lys Gly Ser Ala Leu Gly Asn Ala Val Asn Leu Ala Val Leu Lys
    770                 775                 780                 
Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr
785                 790                 795                 800 
Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr
                805                 810                 815     
Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val
            820                 825                 830         
Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr
        835                 840                 845             
Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln
    850                 855                 860                 
Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr
865                 870                 875                 880 
Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile
                885                 890                 


<210> 9316
<211> 1438
<212> PRT
<213> Homo sapiens

<400> 9316
Ala Ala Pro Arg Ser Phe Pro Leu Arg Leu Pro Arg Gly Asp Glu Ser
 1               5                  10                  15      
Ala Gln Arg Gly Gly Arg Arg Pro Pro Thr Leu Cys Ala Leu Ser Pro
            20                  25                  30          
Ala Pro Ala Ala Gln Pro Ser Pro Val Arg Pro Ala Glu Thr Met Asp
        35                  40                  45              
Thr Glu Asp Asp Pro Leu Leu Gln Asp Val Trp Leu Glu Glu Glu Gln
    50                  55                  60                  
Glu Glu Glu Glu Ala Thr Gly Glu Thr Phe Leu Gly Ala Gln Lys Pro
65                  70                  75                  80  
Gly Pro Gln Pro Gly Ala Gly Gly Gln Cys Cys Trp Arg His Trp Pro
                85                  90                  95      
Leu Ala Ser Arg Pro Pro Ala Ser Gly Phe Trp Ser Thr Leu Gly Trp
            100                 105                 110         
Ala Phe Thr Asn Pro Cys Cys Ala Gly Leu Val Leu Phe Leu Gly Cys
        115                 120                 125             
Ser Ile Pro Met Ala Leu Ser Ala Phe Met Phe Leu Tyr Tyr Pro Pro
    130                 135                 140                 
Leu Asp Ile Asp Ile Ser Tyr Asn Ala Phe Glu Ile Arg Asn His Glu
145                 150                 155                 160 
Ala Ser Gln Arg Phe Asp Ala Leu Thr Leu Ala Leu Lys Ser Gln Phe
                165                 170                 175     
Gly Ser Trp Gly Arg Asn Arg Arg Asp Leu Ala Asp Phe Thr Ser Glu
            180                 185                 190         
Thr Leu Gln Arg Leu Ile Ser Glu Gln Leu Gln Gln Leu His Leu Gly
        195                 200                 205             
Asn Arg Ser Arg Gln Ala Ser Arg Ala Pro Arg Val Ile Pro Ala Ala
    210                 215                 220                 
Ser Leu Gly Ser Pro Gly Pro Tyr Arg Asp Thr Ser Ala Ala Gln Lys
225                 230                 235                 240 
Pro Thr Ala Asn Arg Ser Gly Arg Leu Arg Arg Glu Thr Pro Pro Leu
                245                 250                 255     
Glu Asp Leu Ala Ala Asn Gln Ser Glu Asp Pro Arg Asn Gln Arg Leu
            260                 265                 270         
Ser Lys Asn Gly Arg Tyr Gln Pro Ser Ile Pro Pro His Ala Ala Val
        275                 280                 285             
Ala Ala Asn Gln Ser Arg Ala Arg Arg Gly Ala Ser Arg Trp Asp Tyr
    290                 295                 300                 
Ser Arg Ala Tyr Val Ser Ala Asn Thr Gln Thr His Ala His Trp Arg
305                 310                 315                 320 
Ile Glu Leu Ile Phe Leu Ala Arg Gly Asp Ala Glu Arg Asn Ile Phe
                325                 330                 335     
Thr Ser Glu Arg Leu Val Thr Ile His Glu Ile Glu Arg Lys Ile Met
            340                 345                 350         
Asp His Pro Gly Phe Arg Glu Phe Cys Trp Lys Pro His Glu Val Leu
        355                 360                 365             
Lys Asp Leu Pro Leu Gly Ser Tyr Ser Tyr Cys Ser Pro Pro Ser Ser
    370                 375                 380                 
Leu Met Thr Tyr Phe Phe Pro Thr Glu Arg Gly Gly Lys Ile Tyr Tyr
385                 390                 395                 400 
Asp Gly Met Gly Gln Asp Leu Ala Asp Ile Arg Gly Ser Leu Glu Leu
                405                 410                 415     
Ala Met Thr His Pro Glu Phe Tyr Trp Tyr Val Asp Glu Gly Leu Ser
            420                 425                 430         
Ala Asp Asn Leu Lys Ser Ser Leu Leu Arg Ser Glu Ile Leu Phe Gly
        435                 440                 445             
Ala Pro Leu Pro Asn Tyr Tyr Ser Val Asp Asp Arg Trp Glu Glu Gln
    450                 455                 460                 
Arg Ala Lys Phe Gln Ser Phe Val Val Thr Tyr Val Ala Met Leu Ala
465                 470                 475                 480 
Lys Gln Ser Thr Ser Lys Val Gln Val Leu Tyr Gly Gly Thr Asp Leu
                485                 490                 495     
Phe Asp Tyr Glu Val Arg Arg Thr Phe Asn Asn Asp Met Leu Leu Ala
            500                 505                 510         
Phe Ile Ser Ser Ser Cys Ile Ala Ala Leu Val Tyr Ile Leu Thr Ser
        515                 520                 525             
Cys Ser Val Phe Leu Ser Phe Phe Gly Ile Ala Ser Ile Gly Leu Ser
    530                 535                 540                 
Cys Leu Val Ala Leu Phe Leu Tyr His Val Val Phe Gly Ile Gln Tyr
545                 550                 555                 560 
Leu Gly Ile Leu Asn Gly Val Ala Ala Phe Val Ile Val Gly Ile Gly
                565                 570                 575     
Val Asp Asp Val Phe Val Phe Ile Asn Thr Tyr Arg Gln Ala Thr His
            580                 585                 590         
Leu Glu Asp Pro Gln Leu Arg Met Ile His Thr Val Gln Thr Ala Gly
        595                 600                 605             
Lys Ala Thr Phe Phe Thr Ser Leu Thr Thr Ala Ala Ala Tyr Ala Ala
    610                 615                 620                 
Asn Val Phe Ser Gln Ile Pro Ala Val His Asp Phe Gly Leu Phe Met
625                 630                 635                 640 
Ser Leu Ile Val Ser Cys Cys Trp Leu Ala Val Leu Val Thr Met Pro
                645                 650                 655     
Ala Ala Leu Gly Leu Trp Ser Leu Tyr Leu Ala Pro Leu Glu Ser Ser
            660                 665                 670         
Cys Gln Thr Ser Cys His Gln Asn Cys Ser Arg Lys Thr Ser Leu His
        675                 680                 685             
Phe Pro Gly Asp Val Phe Ala Thr Pro Glu Gln Val Gly Gly Ser Pro
    690                 695                 700                 
Ala Gln Gly Pro Ile Pro Tyr Leu Asp Asp Asp Ile Pro Leu Leu Glu
705                 710                 715                 720 
Val Glu Glu Glu Pro Val Ser Leu Glu Leu Gly Asp Val Ser Leu Val
                725                 730                 735     
Ser Val Ser Pro Glu Gly Leu Gln Pro Ala Ser Asn Thr Gly Ser Arg
            740                 745                 750         
Gly His Leu Ile Val Gln Leu Gln Glu Leu Leu His His Trp Val Leu
        755                 760                 765             
Trp Ser Ala Val Lys Ser Arg Trp Val Ile Val Gly Leu Phe Val Ser
    770                 775                 780                 
Ile Leu Ile Leu Ser Leu Val Phe Ala Ser Arg Leu Arg Pro Ala Ser
785                 790                 795                 800 
Arg Ala Pro Leu Leu Phe Arg Pro Asp Thr Asn Ile Gln Val Leu Leu
                805                 810                 815     
Asp Leu Lys Tyr Asn Leu Ser Ala Glu Gly Ile Ser Cys Ile Thr Cys
            820                 825                 830         
Ser Gly Leu Phe Gln Glu Lys Pro His Ser Leu Gln Asn Asn Ile Arg
        835                 840                 845             
Thr Ser Leu Glu Lys Lys Arg Arg Gly Ser Gly Val Pro Trp Ala Ser
    850                 855                 860                 
Arg Pro Glu Ala Thr Leu Gln Asp Phe Pro Gly Thr Val Tyr Ile Ser
865                 870                 875                 880 
Lys Val Lys Ser Gln Gly His Pro Ala Val Tyr Arg Leu Ser Leu Asn
                885                 890                 895     
Ala Ser Leu Pro Ala Pro Trp Gln Ala Val Ser Pro Gly Asp Gly Glu
            900                 905                 910         
Val Pro Ser Phe Gln Val Tyr Arg Ala Pro Phe Gly Asn Phe Thr Lys
        915                 920                 925             
Lys Leu Thr Ala Cys Met Ser Thr Val Gly Leu Leu Gln Ala Ala Ser
    930                 935                 940                 
Pro Ser Arg Lys Trp Met Leu Thr Thr Leu Ala Cys Asp Ala Lys Arg
945                 950                 955                 960 
Gly Trp Lys Phe Asp Phe Ser Phe Tyr Val Ala Thr Lys Glu Gln Gln
                965                 970                 975     
His Thr Arg Lys Leu Tyr Phe Ala Gln Ser His Lys Pro Pro Phe His
            980                 985                 990         
Gly Arg Val Cys Met Ala Pro Pro Gly Cys Leu Leu Ser Ser Ser Pro
        995                 1000                1005            
Asp Gly Pro Thr Lys Gly Phe Phe Phe Val Pro Ser Glu Lys Val Pro
    1010                1015                1020                
Lys Ala Arg Leu Ser Ala Thr Phe Gly Phe Asn Pro Cys Val Asn Thr
1025                1030                1035                1040
Gly Cys Gly Lys Pro Ala Val Arg Pro Leu Val Asp Thr Gly Ala Met
                1045                1050                1055    
Val Phe Val Val Phe Gly Ile Ile Gly Val Asn Arg Thr Arg Gln Val
            1060                1065                1070        
Asp Asn His Val Ile Gly Asp Pro Gly Ser Val Val Tyr Asp Ser Ser
        1075                1080                1085            
Phe Asp Leu Phe Lys Glu Ile Gly His Leu Cys His Leu Cys Lys Ala
    1090                1095                1100                
Ile Ala Ala Asn Ser Glu Leu Val Lys Pro Gly Gly Ala Gln Cys Leu
1105                1110                1115                1120
Pro Ser Gly Tyr Ser Ile Ser Ser Phe Leu Gln Met Leu His Pro Glu
                1125                1130                1135    
Cys Lys Glu Leu Pro Glu Pro Asn Leu Leu Pro Gly Gln Leu Ser His
            1140                1145                1150        
Gly Ala Val Gly Val Arg Glu Gly Arg Val Gln Trp Ile Ser Met Ala
        1155                1160                1165            
Phe Glu Ser Thr Thr Tyr Lys Gly Lys Ser Ser Phe Gln Thr Tyr Ser
    1170                1175                1180                
Asp Tyr Leu Arg Trp Glu Ser Phe Leu Gln Gln Gln Leu Gln Ala Leu
1185                1190                1195                1200
Pro Glu Gly Ser Val Leu Arg Arg Gly Phe Gln Thr Cys Glu His Trp
                1205                1210                1215    
Lys Gln Ile Phe Met Glu Ile Val Gly Val Gln Ser Ala Leu Cys Gly
            1220                1225                1230        
Leu Val Leu Ser Leu Leu Ile Cys Val Ala Ala Val Ala Val Phe Thr
        1235                1240                1245            
Thr His Ile Leu Leu Leu Leu Pro Val Leu Leu Ser Ile Leu Gly Ile
    1250                1255                1260                
Val Cys Leu Val Val Thr Ile Met Tyr Trp Ser Gly Trp Glu Met Gly
1265                1270                1275                1280
Ala Val Glu Ala Ile Ser Leu Ser Ile Leu Val Gly Ser Ser Val Asp
                1285                1290                1295    
Tyr Cys Val His Leu Val Glu Gly Tyr Leu Leu Ala Gly Glu Asn Leu
            1300                1305                1310        
Pro Pro His Gln Ala Glu Asp Ala Arg Thr Gln Arg Gln Trp Arg Thr
        1315                1320                1325            
Leu Glu Ala Val Arg His Val Gly Val Ala Ile Val Ser Ser Ala Leu
    1330                1335                1340                
Thr Thr Val Ile Ala Thr Val Pro Leu Phe Phe Cys Ile Ile Ala Pro
1345                1350                1355                1360
Phe Ala Lys Phe Gly Lys Ile Val Ala Leu Asn Thr Gly Val Ser Ile
                1365                1370                1375    
Leu Tyr Thr Leu Thr Val Ser Thr Ala Leu Leu Gly Ile Met Ala Pro
            1380                1385                1390        
Ser Ser Phe Thr Arg Thr Arg Thr Ser Phe Leu Lys Ala Leu Gly Ala
        1395                1400                1405            
Val Leu Leu Ala Gly Ala Leu Gly Leu Gly Ala Cys Leu Val Leu Leu
    1410                1415                1420                
Gln Ser Gly Tyr Lys Ile Pro Leu Pro Ala Gly Ala Ser Leu
1425                1430                1435            


<210> 9317
<211> 425
<212> PRT
<213> Homo sapiens

<400> 9317
Met Asp Gly Pro Ala Glu Gln Arg Pro Ala Leu Leu Asn Ser Ala Glu
 1               5                  10                  15      
Asn Phe Thr Val Leu Ile Lys Asn Asn Ile Asp Phe Pro Gly His Asn
            20                  25                  30          
Tyr Thr Thr Arg Asn Ile Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe
        35                  40                  45              
His Lys Thr Gln Asn Pro Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile
    50                  55                  60                  
Phe Arg Glu Thr Gly Asp Asn Phe Ser Asp Val Ala Ile Gln Gly Gly
65                  70                  75                  80  
Ile Met Gly Ile Glu Ile Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe
                85                  90                  95      
His His Cys Arg Pro Lys Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr
            100                 105                 110         
Thr Asn Val Ser Leu Tyr Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr
        115                 120                 125             
Tyr Lys Glu Asn Asn Val Glu Lys Arg Thr Leu Ile Lys Val Phe Gly
    130                 135                 140                 
Ile Arg Phe Asp Ile Leu Val Phe Gly Thr Gly Gly Lys Phe Asp Ile
145                 150                 155                 160 
Ile Gln Leu Val Val Tyr Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu
                165                 170                 175     
Ala Ala Val Phe Ile Asp Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys
            180                 185                 190         
Cys Arg Ser His Ile Tyr Pro Trp Cys Lys Cys Cys Gln Pro Cys Val
        195                 200                 205             
Val Asn Glu Tyr Tyr Tyr Arg Lys Lys Cys Glu Ser Ile Val Glu Pro
    210                 215                 220                 
Lys Pro Thr Leu Lys Tyr Val Ser Phe Val Asp Glu Ser His Ile Arg
225                 230                 235                 240 
Met Val Asn Gln Gln Leu Leu Gly Arg Ser Leu Gln Asp Val Lys Gly
                245                 250                 255     
Gln Glu Val Pro Arg Pro Ala Met Asp Phe Thr Asp Leu Ser Arg Leu
            260                 265                 270         
Pro Leu Ala Leu His Asp Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu
        275                 280                 285             
Ile Gln Leu Leu Arg Lys Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro
    290                 295                 300                 
Val Trp Cys Gln Cys Gly Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser
305                 310                 315                 320 
His Arg Cys Leu Glu Ala Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys
                325                 330                 335     
Ile Thr Thr Ser Glu Leu Phe Arg Lys Leu Val Leu Ser Arg His Val
            340                 345                 350         
Leu Gln Phe Leu Leu Leu Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val
        355                 360                 365             
Asp Ser Thr Asn Ser Arg Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala
    370                 375                 380                 
Thr Trp Arg Phe Gly Ser Gln Asp Met Ala Asp Phe Ala Ile Leu Pro
385                 390                 395                 400 
Ser Cys Cys Arg Trp Arg Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly
                405                 410                 415     
Gln Tyr Ser Gly Phe Lys Ser Pro Tyr
            420                 425 


<210> 9318
<211> 595
<212> PRT
<213> Homo sapiens

<400> 9318
Met Pro Ala Cys Cys Ser Cys Ser Asp Val Phe Gln Tyr Glu Thr Asn
 1               5                  10                  15      
Lys Val Thr Arg Ile Gln Ser Met Asn Tyr Gly Thr Ile Lys Trp Phe
            20                  25                  30          
Phe His Val Ile Ile Phe Ser Tyr Val Cys Phe Ala Leu Val Ser Asp
        35                  40                  45              
Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His Thr Lys
    50                  55                  60                  
Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn Gly Val
65                  70                  75                  80  
Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr Phe Pro
                85                  90                  95      
Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys Thr Glu
            100                 105                 110         
Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg Thr Leu
        115                 120                 125             
Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro Gln Ser
    130                 135                 140                 
Lys Gly Ile Gln Thr Gly Arg Cys Val Val His Glu Gly Asn Gln Lys
145                 150                 155                 160 
Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu Glu Ala
                165                 170                 175     
Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val Leu Ile
            180                 185                 190         
Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg Asn Ile
        195                 200                 205             
Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln Asn Pro
    210                 215                 220                 
Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr Gly Asp
225                 230                 235                 240 
Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile Glu Ile
                245                 250                 255     
Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg Pro Lys
            260                 265                 270         
Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser Leu Tyr
        275                 280                 285             
Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn Asn Val
    290                 295                 300                 
Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp Ile Leu
305                 310                 315                 320 
Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val Val Tyr
                325                 330                 335     
Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu Ala Ala Val Phe Ile Asp
            340                 345                 350         
Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys Cys Arg Ser His Ile Tyr
        355                 360                 365             
Pro Trp Cys Lys Cys Cys Gln Pro Cys Val Val Asn Glu Tyr Tyr Tyr
    370                 375                 380                 
Arg Lys Lys Cys Glu Ser Ile Val Glu Pro Lys Pro Thr Leu Lys Tyr
385                 390                 395                 400 
Val Ser Phe Val Asp Glu Ser His Ile Arg Met Val Asn Gln Gln Leu
                405                 410                 415     
Leu Gly Arg Ser Leu Gln Asp Val Lys Gly Gln Glu Val Pro Arg Pro
            420                 425                 430         
Ala Met Asp Phe Thr Asp Leu Ser Arg Leu Pro Leu Ala Leu His Asp
        435                 440                 445             
Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu Ile Gln Leu Leu Arg Lys
    450                 455                 460                 
Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro Val Trp Cys Gln Cys Gly
465                 470                 475                 480 
Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser His Arg Cys Leu Glu Glu
                485                 490                 495     
Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys Ile Thr Thr Ser Glu Leu
            500                 505                 510         
Phe Arg Lys Leu Val Leu Ser Arg His Val Leu Gln Phe Leu Leu Leu
        515                 520                 525             
Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val Asp Ser Thr Asn Ser Arg
    530                 535                 540                 
Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala Thr Trp Arg Phe Gly Ser
545                 550                 555                 560 
Gln Asp Met Ala Asp Phe Ala Ile Leu Pro Ser Cys Cys Arg Trp Arg
                565                 570                 575     
Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly Gln Tyr Ser Gly Phe Lys
            580                 585                 590         
Ser Pro Tyr
        595 


<210> 9319
<211> 676
<212> PRT
<213> Homo sapiens

<400> 9319
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp
 1               5                  10                  15      
Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Thr Ala Thr Val Leu Ala
            20                  25                  30          
Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln
        35                  40                  45              
Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp Leu Arg Lys Gln Val
    50                  55                  60                  
Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys
65                  70                  75                  80  
Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu
                85                  90                  95      
Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu
            100                 105                 110         
Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Thr Glu Asn Gln Lys
        115                 120                 125             
Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys
    130                 135                 140                 
Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr
145                 150                 155                 160 
Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile Ala Leu Glu Lys Glu
                165                 170                 175     
Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu
            180                 185                 190         
Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu Ala Glu His Lys Val
        195                 200                 205             
Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg Thr Glu Leu Phe Asp
    210                 215                 220                 
Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala Lys Ala Asp Glu Ile
225                 230                 235                 240 
Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val
                245                 250                 255     
Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln Leu Ser Ser Ala Asn
            260                 265                 270         
His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Ala
        275                 280                 285             
Ile Glu Val Leu Thr Arg Ser Ser Leu Glu Val Glu Leu Ala Ala Lys
    290                 295                 300                 
Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu Gln Ala
305                 310                 315                 320 
Ser Leu Thr Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser Gln Leu
                325                 330                 335     
Glu Gln Gln Leu Ser Ala Lys Asn Ser Thr Leu Lys Gln Leu Glu Glu
            340                 345                 350         
Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu Leu Asn
        355                 360                 365             
Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly Thr Gln
    370                 375                 380                 
Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn Arg Ser
385                 390                 395                 400 
Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp Leu Ser
                405                 410                 415     
Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Thr Glu Ala Val Ala Thr
            420                 425                 430         
Ala Thr Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu Gln Asp Leu Ser
        435                 440                 445             
Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly Ala Ala Glu His
    450                 455                 460                 
Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala Thr Ala Leu Phe
465                 470                 475                 480 
Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro Glu Gly Gln Val
                485                 490                 495     
Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu Arg Phe Arg Ala
            500                 505                 510         
Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala Gln His Thr Leu
        515                 520                 525             
Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala Asp Asn Ile Lys
    530                 535                 540                 
Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro Gly Arg Gly Ser
545                 550                 555                 560 
Gly Ser Asp Asp Thr Glu Leu Arg Tyr Ser Ser Gln Tyr Glu Glu Arg
                565                 570                 575     
Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg Gln Arg Lys Tyr
            580                 585                 590         
Leu Ser Leu Ser Pro Trp Asp Lys Ala Thr Leu Ser Met Gly Arg Leu
        595                 600                 605             
Val Leu Ser Asn Lys Met Ala Arg Thr Ile Gly Phe Phe Tyr Thr Leu
    610                 615                 620                 
Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys Leu Ala Trp Ser
625                 630                 635                 640 
Glu Ser Met Glu Arg Asp Cys Ala Thr Phe Cys Ala Lys Lys Phe Ala
                645                 650                 655     
Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala Ala Ala Gly
            660                 665                 670         
Asp Leu Trp Gln
        675     


<210> 9320
<211> 1516
<212> PRT
<213> Homo sapiens

<400> 9320
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp
 1               5                  10                  15      
Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Thr Ala Thr Val Leu Ala
            20                  25                  30          
Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln
        35                  40                  45              
Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp Leu Arg Lys Gln Val
    50                  55                  60                  
Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys
65                  70                  75                  80  
Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu
                85                  90                  95      
Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu
            100                 105                 110         
Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Thr Glu Asn Gln Lys
        115                 120                 125             
Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys
    130                 135                 140                 
Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr
145                 150                 155                 160 
Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile Ala Leu Glu Lys Glu
                165                 170                 175     
Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu
            180                 185                 190         
Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu Ala Glu His Lys Val
        195                 200                 205             
Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg Thr Glu Leu Phe Asp
    210                 215                 220                 
Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala Lys Ala Asp Glu Ile
225                 230                 235                 240 
Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val
                245                 250                 255     
Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln Leu Ser Ser Ala Asn
            260                 265                 270         
His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Glu
        275                 280                 285             
Gln Ala Ile Glu Val Leu Thr Arg Ser Ser Leu Glu Val Glu Leu Ala
    290                 295                 300                 
Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu
305                 310                 315                 320 
Gln Ala Ser Leu Thr Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser
                325                 330                 335     
Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Thr Leu Lys Gln Leu
            340                 345                 350         
Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu
        355                 360                 365             
Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly
    370                 375                 380                 
Thr Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn
385                 390                 395                 400 
Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp
                405                 410                 415     
Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp Gln Pro Glu Ser Arg
            420                 425                 430         
Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser Gln Leu Pro Arg Asn
        435                 440                 445             
Pro Gly Glu Gln Ala Ser Asn Thr Asn Gly Thr His Gln Phe Ser Pro
    450                 455                 460                 
Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser Leu Ala Ser Pro Ser
465                 470                 475                 480 
Leu Pro Leu Ala Ser Thr Gly Lys Phe Ala Leu Asn Ser Leu Leu Gln
                485                 490                 495     
Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala Met Gln Glu Ala Gly
            500                 505                 510         
Ser Thr Ser Met Ile Phe Ser Thr Gly Pro Tyr Ser Thr Asn Ser Ile
        515                 520                 525             
Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp Val Asn Gly Met Ala
    530                 535                 540                 
Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser Val Ser Glu Gly Glu
545                 550                 555                 560 
Glu Met Asp Thr Ala Glu Ile Ala Arg Gln Val Lys Glu Gln Leu Ile
                565                 570                 575     
Lys His Asn Ile Gly Gln Arg Ile Phe Gly His Tyr Val Leu Gly Leu
            580                 585                 590         
Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg Pro Lys Pro Trp Asn
        595                 600                 605             
Lys Leu Thr Val Arg Gly Lys Glu Pro Phe His Lys Met Lys Gln Phe
    610                 615                 620                 
Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg Ser Ile Gln Gly Arg
625                 630                 635                 640 
Gln Arg Glu Asn Pro Gly Gln Ser Leu Asn Arg Leu Phe Gln Glu Val
                645                 650                 655     
Pro Lys Arg Arg Asn Gly Ser Glu Gly Asn Ile Thr Thr Arg Ile Arg
            660                 665                 670         
Ala Ser Glu Thr Gly Ser Asp Glu Ala Ile Lys Ser Ile Leu Glu Gln
        675                 680                 685             
Ala Lys Arg Glu Leu Gln Val Gln Lys Thr Ala Glu Pro Ala Gln Pro
    690                 695                 700                 
Ser Ser Ala Ser Gly Ser Gly Asn Ser Asp Asp Ala Ile Arg Ser Ile
705                 710                 715                 720 
Leu Gln Gln Ala Arg Arg Glu Met Glu Ala Gln Gln Ala Ala Leu Asp
                725                 730                 735     
Pro Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser Asp Ile Thr Ile Leu
            740                 745                 750         
Thr Pro Lys Leu Leu Ser Thr Ser Pro Met Pro Thr Val Ser Ser Tyr
        755                 760                 765             
Pro Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser Ala Ala Pro Glu Ala
    770                 775                 780                 
Gly Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu Lys Lys Glu Ala Gln
785                 790                 795                 800 
Asp Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala Asp Cys Ala Gln Gly
                805                 810                 815     
Val Leu Arg Gln Val Lys Asn Glu Val Gly Arg Ser Gly Ala Trp Lys
            820                 825                 830         
Asp His Trp Trp Ser Ala Val Gln Pro Glu Arg Arg Asn Ala Ala Ser
        835                 840                 845             
Ser Glu Glu Ala Lys Ala Glu Glu Thr Gly Gly Gly Lys Glu Lys Gly
    850                 855                 860                 
Ser Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg Ala Glu Arg Ser Gln
865                 870                 875                 880 
Leu Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys Glu Trp Pro Ser Ala
                885                 890                 895     
Glu Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser Leu Thr Gly Ala Ser
            900                 905                 910         
Arg Ser Glu Thr Pro Gln Asn Ser Pro Leu Pro Ser Ser Pro Ile Val
        915                 920                 925             
Pro Met Ser Lys Pro Thr Lys Pro Ser Val Pro Pro Leu Thr Pro Glu
    930                 935                 940                 
Gln Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp Thr Ile Glu Leu Thr
945                 950                 955                 960 
Arg Gln Val Lys Glu Lys Leu Ala Lys Asn Gly Ile Cys Gln Arg Ile
                965                 970                 975     
Phe Gly Glu Lys Val Leu Gly Leu Ser Gln Gly Ser Val Ser Asp Met
            980                 985                 990         
Leu Ser Arg Pro Lys Pro Trp Ser Lys Leu Thr Gln Lys Gly Arg Glu
        995                 1000                1005            
Pro Phe Ile Arg Met Gln Leu Trp Leu Asn Gly Glu Leu Gly Gln Gly
    1010                1015                1020                
Val Leu Pro Val Gln Gly Gln Gln Gln Gly Pro Val Leu His Ser Val
1025                1030                1035                1040
Thr Ser Leu Gln Asp Pro Leu Gln Gln Gly Cys Val Ser Ser Glu Ser
                1045                1050                1055    
Thr Pro Lys Thr Ser Ala Ser Cys Ser Pro Ala Pro Glu Ser Pro Met
            1060                1065                1070        
Ser Ser Ser Glu Ser Val Lys Ser Leu Thr Glu Leu Val Gln Gln Pro
        1075                1080                1085            
Cys Pro Pro Ile Glu Ala Ser Lys Asp Ser Lys Pro Pro Glu Pro Ser
    1090                1095                1100                
Asp Pro Pro Ala Ser Asp Ser Gln Pro Thr Thr Pro Leu Pro Leu Ser
1105                1110                1115                1120
Gly His Ser Ala Leu Ser Ile Gln Glu Leu Val Ala Met Ser Pro Glu
                1125                1130                1135    
Leu Asp Thr Tyr Gly Ile Thr Lys Arg Val Lys Glu Val Leu Thr Asp
            1140                1145                1150        
Asn Asn Leu Gly Gln Arg Leu Phe Gly Glu Thr Ile Leu Gly Leu Thr
        1155                1160                1165            
Gln Gly Ser Val Ser Asp Leu Leu Ala Arg Pro Lys Pro Trp His Lys
    1170                1175                1180                
Leu Ser Leu Lys Gly Arg Glu Pro Phe Val Arg Met Gln Leu Trp Leu
1185                1190                1195                1200
Asn Asp Pro Asn Asn Val Glu Lys Leu Met Asp Met Lys Arg Met Glu
                1205                1210                1215    
Lys Lys Ala Tyr Met Lys Arg Arg His Ser Ser Val Ser Asp Ser Gln
            1220                1225                1230        
Pro Cys Glu Pro Pro Ser Val Gly Thr Glu Tyr Ser Gln Gly Ala Ser
        1235                1240                1245            
Pro Gln Pro Gln His Gln Leu Lys Lys Pro Arg Val Val Leu Ala Pro
    1250                1255                1260                
Glu Glu Lys Glu Ala Leu Lys Arg Ala Tyr Gln Gln Lys Pro Tyr Pro
1265                1270                1275                1280
Ser Pro Lys Thr Ile Glu Asp Leu Ala Thr Gln Leu Asn Leu Lys Thr
                1285                1290                1295    
Ser Thr Val Ile Asn Trp Phe His Asn Tyr Arg Ser Arg Ile Arg Arg
            1300                1305                1310        
Glu Leu Phe Ile Glu Glu Ile Gln Ala Gly Ser Gln Gly Gln Ala Gly
        1315                1320                1325            
Ala Ser Asp Ser Pro Ser Ala Arg Ser Gly Arg Ala Ala Pro Ser Ser
    1330                1335                1340                
Glu Gly Asp Ser Cys Asp Gly Val Glu Ala Thr Glu Gly Pro Gly Ser
1345                1350                1355                1360
Ala Asp Thr Glu Glu Pro Lys Ser Gln Gly Glu Ala Glu Arg Glu Glu
                1365                1370                1375    
Val Pro Arg Pro Ala Glu Gln Thr Glu Pro Pro Pro Ser Gly Thr Pro
            1380                1385                1390        
Gly Pro Asp Asp Ala Arg Asp Asp Asp His Glu Gly Gly Pro Val Glu
        1395                1400                1405            
Gly Pro Gly Pro Leu Pro Ser Pro Ala Ser Ala Thr Ala Thr Ala Ala
    1410                1415                1420                
Pro Ala Ala Pro Glu Asp Ala Ala Thr Ser Ala Ala Ala Ala Pro Gly
1425                1430                1435                1440
Glu Gly Pro Ala Ala Pro Ser Ser Ala Pro Pro Pro Ser Asn Ser Ser
                1445                1450                1455    
Ser Ser Ser Ala Pro Arg Arg Pro Ser Ser Leu Gln Ser Leu Phe Gly
            1460                1465                1470        
Leu Pro Glu Ala Ala Gly Ala Arg Asp Ser Arg Asp Asn Pro Leu Arg
        1475                1480                1485            
Lys Lys Lys Ala Ala Asn Leu Asn Ser Ile Ile His Arg Leu Glu Lys
    1490                1495                1500                
Ala Ala Ser Arg Glu Glu Pro Ile Glu Trp Glu Phe
1505                1510                1515    


<210> 9321
<211> 678
<212> PRT
<213> Homo sapiens

<400> 9321
Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp
 1               5                  10                  15      
Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Thr Ala Thr Val Leu Ala
            20                  25                  30          
Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln
        35                  40                  45              
Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp Leu Arg Lys Gln Val
    50                  55                  60                  
Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys
65                  70                  75                  80  
Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu
                85                  90                  95      
Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu
            100                 105                 110         
Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Thr Glu Asn Gln Lys
        115                 120                 125             
Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys
    130                 135                 140                 
Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr
145                 150                 155                 160 
Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile Ala Leu Glu Lys Glu
                165                 170                 175     
Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu
            180                 185                 190         
Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu Ala Glu His Lys Val
        195                 200                 205             
Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg Thr Glu Leu Phe Asp
    210                 215                 220                 
Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala Lys Ala Asp Glu Ile
225                 230                 235                 240 
Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val
                245                 250                 255     
Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln Leu Ser Ser Ala Asn
            260                 265                 270         
His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Glu
        275                 280                 285             
Gln Ala Ile Glu Val Leu Thr Arg Ser Ser Leu Glu Val Glu Leu Ala
    290                 295                 300                 
Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu
305                 310                 315                 320 
Gln Ala Ser Leu Thr Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser
                325                 330                 335     
Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Thr Leu Lys Gln Leu
            340                 345                 350         
Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu
        355                 360                 365             
Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly
    370                 375                 380                 
Thr Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn
385                 390                 395                 400 
Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp
                405                 410                 415     
Leu Ser Gly Arg Cys Ala Glu Leu Gln Val Arg Ile Thr Glu Ala Val
            420                 425                 430         
Ala Thr Ala Thr Glu Gln Arg Glu Leu Ile Ala Arg Leu Glu Gln Asp
        435                 440                 445             
Leu Ser Ile Ile Gln Ser Ile Gln Arg Pro Asp Ala Glu Gly Ala Ala
    450                 455                 460                 
Glu His Arg Leu Glu Lys Ile Pro Glu Pro Ile Lys Glu Ala Thr Ala
465                 470                 475                 480 
Leu Phe Tyr Gly Pro Ala Ala Pro Ala Ser Gly Ala Leu Pro Glu Gly
                485                 490                 495     
Gln Val Asp Ser Leu Leu Ser Ile Ile Ser Ser Gln Arg Glu Arg Phe
            500                 505                 510         
Arg Ala Arg Asn Gln Glu Leu Glu Ala Glu Asn Arg Leu Ala Gln His
        515                 520                 525             
Thr Leu Gln Ala Leu Gln Ser Glu Leu Asp Ser Leu Arg Ala Asp Asn
    530                 535                 540                 
Ile Lys Leu Phe Glu Lys Ile Lys Phe Leu Gln Ser Tyr Pro Gly Arg
545                 550                 555                 560 
Gly Ser Gly Ser Asp Asp Thr Glu Leu Arg Tyr Ser Ser Gln Tyr Glu
                565                 570                 575     
Glu Arg Leu Asp Pro Phe Ser Ser Phe Ser Lys Arg Glu Arg Gln Arg
            580                 585                 590         
Lys Tyr Leu Ser Leu Ser Pro Trp Asp Lys Ala Thr Leu Ser Met Gly
        595                 600                 605             
Arg Leu Val Leu Ser Asn Lys Met Ala Arg Thr Ile Gly Phe Phe Tyr
    610                 615                 620                 
Thr Leu Phe Leu His Cys Leu Val Phe Leu Val Leu Tyr Lys Leu Ala
625                 630                 635                 640 
Trp Ser Glu Ser Met Glu Arg Asp Cys Ala Thr Phe Cys Ala Lys Lys
                645                 650                 655     
Leu Ala Asp His Leu His Lys Phe His Glu Asn Asp Asn Gly Ala Ala
            660                 665                 670         
Ala Gly Asp Leu Trp Gln
        675             


<210> 9322
<211> 1505
<212> PRT
<213> Homo sapiens

<400> 9322
Met Leu Cys Val Arg Gly Ala Arg Leu Lys Arg Glu Leu Asp Ala Thr
 1               5                  10                  15      
Ala Thr Val Leu Ala Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys
            20                  25                  30          
Arg Leu Ile Glu Gln Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp
        35                  40                  45              
Leu Arg Lys Gln Val Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile
    50                  55                  60                  
Asp Ala Leu Ser Lys Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn
65                  70                  75                  80  
Val Tyr Lys Arg Leu Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp
                85                  90                  95      
Leu Gly Gln Gln Leu Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu
            100                 105                 110         
Thr Glu Asn Gln Lys Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu
        115                 120                 125             
Phe Ala Glu Val Lys Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu
    130                 135                 140                 
Lys Ile Arg Glu Tyr Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile
145                 150                 155                 160 
Ala Leu Glu Lys Glu Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu
                165                 170                 175     
Arg Lys Leu Gln Glu Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu
            180                 185                 190         
Ala Glu His Lys Val Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg
        195                 200                 205             
Thr Glu Leu Phe Asp Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala
    210                 215                 220                 
Lys Ala Asp Glu Ile Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn
225                 230                 235                 240 
Gln Arg Ala Glu Val Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln
                245                 250                 255     
Leu Ser Ser Ala Asn His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys
            260                 265                 270         
Ala Pro Asp Val Glu Gln Ala Ile Glu Val Leu Thr Arg Ser Ser Leu
        275                 280                 285             
Glu Val Glu Leu Ala Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu
    290                 295                 300                 
Asp Val Gln Arg Leu Gln Ala Ser Leu Thr Lys Leu Arg Glu Asn Ser
305                 310                 315                 320 
Ala Ser Gln Ile Ser Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser
                325                 330                 335     
Thr Leu Lys Gln Leu Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu
            340                 345                 350         
Glu Val Lys Lys Glu Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro
        355                 360                 365             
Ser Glu Gly Ala Gly Thr Gln Asp Ala Ala Lys Pro Leu Glu Val Leu
    370                 375                 380                 
Leu Leu Glu Lys Asn Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg
385                 390                 395                 400 
Ile Ser Asn Ser Asp Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp
                405                 410                 415     
Gln Pro Glu Ser Arg Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser
            420                 425                 430         
Gln Leu Pro Arg Asn Pro Gly Glu Gln Ala Ser Asn Thr Asn Gly Thr
        435                 440                 445             
His Gln Phe Ser Pro Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser
    450                 455                 460                 
Leu Ala Ser Pro Ser Leu Pro Leu Ala Ser Thr Gly Lys Phe Ala Leu
465                 470                 475                 480 
Asn Ser Leu Leu Gln Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala
                485                 490                 495     
Met Gln Glu Ala Gly Ser Thr Ser Met Ile Phe Ser Thr Gly Pro Tyr
            500                 505                 510         
Ser Thr Asn Ser Ile Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp
        515                 520                 525             
Val Asn Gly Met Ala Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser
    530                 535                 540                 
Val Ser Glu Gly Glu Glu Met Asp Thr Ala Glu Ile Ala Arg Gln Val
545                 550                 555                 560 
Lys Glu Gln Leu Ile Lys His Asn Ile Gly Gln Arg Ile Phe Gly His
                565                 570                 575     
Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg
            580                 585                 590         
Pro Lys Pro Trp Asn Lys Leu Thr Val Arg Gly Lys Glu Pro Phe His
        595                 600                 605             
Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg
    610                 615                 620                 
Ser Ile Gln Gly Arg Gln Arg Glu Asn Pro Gly Gln Ser Leu Asn Arg
625                 630                 635                 640 
Leu Phe Gln Glu Val Pro Lys Arg Arg Asn Gly Ser Glu Gly Asn Ile
                645                 650                 655     
Thr Thr Arg Ile Arg Ala Ser Glu Thr Gly Ser Asp Glu Ala Ile Lys
            660                 665                 670         
Ser Ile Leu Glu Gln Ala Lys Arg Glu Leu Gln Val Gln Lys Thr Ala
        675                 680                 685             
Glu Pro Ala Gln Pro Ser Ser Ala Ser Gly Ser Gly Asn Ser Asp Glu
    690                 695                 700                 
Pro Ile Arg Ser Ile Leu Gln Gln Ala Arg Arg Glu Met Glu Ala Gln
705                 710                 715                 720 
Gln Ala Ala Leu Asp Pro Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser
                725                 730                 735     
Asp Ile Thr Ile Leu Thr Pro Lys Leu Leu Ser Thr Ser Pro Met Pro
            740                 745                 750         
Thr Val Ser Ser Tyr Pro Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser
        755                 760                 765             
Ala Ala Pro Glu Ala Gly Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu
    770                 775                 780                 
Lys Lys Glu Ala Gln Asp Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala
785                 790                 795                 800 
Asp Cys Ala Gln Gly Val Leu Arg Gln Val Lys Asn Glu Val Gly Arg
                805                 810                 815     
Ser Gly Ala Trp Lys Asp His Trp Trp Ser Ala Val Gln Pro Glu Arg
            820                 825                 830         
Arg Asn Ala Ala Ser Ser Glu Glu Ala Lys Ala Arg Glu Thr Gly Gly
        835                 840                 845             
Gly Lys Glu Lys Gly Ser Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg
    850                 855                 860                 
Ala Glu Arg Ser Gln Leu Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys
865                 870                 875                 880 
Glu Trp Pro Ser Ala Glu Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser
                885                 890                 895     
Leu Thr Gly Ala Ser Arg Ser Glu Thr Pro Gln Asn Ser Pro Leu Pro
            900                 905                 910         
Ser Ser Pro Ile Val Pro Met Ser Lys Pro Thr Lys Pro Ser Val Pro
        915                 920                 925             
Pro Leu Thr Pro Glu Gln Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp
    930                 935                 940                 
Thr Ile Glu Leu Thr Arg Gln Val Lys Glu Lys Leu Ala Lys Asn Gly
945                 950                 955                 960 
Ile Cys Gln Arg Ile Phe Gly Glu Lys Val Leu Gly Leu Ser Gln Gly
                965                 970                 975     
Ser Val Ser Asp Met Leu Ser Arg Pro Lys Pro Trp Ser Lys Leu Thr
            980                 985                 990         
Gln Lys Gly Arg Glu Pro Phe Ile Arg Met Gln Leu Trp Leu Asn Gly
        995                 1000                1005            
Glu Leu Gly Gln Gly Val Leu Pro Val Gln Gly Gln Gln Gln Gly Pro
    1010                1015                1020                
Val Leu His Ser Val Thr Ser Leu Gln Asp Pro Leu Gln Gln Gly Cys
1025                1030                1035                1040
Val Ser Ser Glu Ser Thr Pro Lys Thr Ser Ala Ser Cys Ser Pro Ala
                1045                1050                1055    
Pro Glu Ser Pro Met Ser Ser Ser Glu Ser Val Lys Ser Leu Thr Glu
            1060                1065                1070        
Leu Val Gln Gln Pro Cys Pro Pro Ile Glu Ala Ser Lys Asp Ser Lys
        1075                1080                1085            
Pro Pro Glu Pro Ser Asp Pro Pro Ala Ser Asp Ser Gln Pro Thr Thr
    1090                1095                1100                
Pro Leu Pro Leu Ser Gly His Ser Ala Leu Ser Ile Gln Glu Leu Val
1105                1110                1115                1120
Ala Met Ser Pro Glu Leu Asp Thr Tyr Gly Ile Thr Lys Arg Val Lys
                1125                1130                1135    
Glu Val Leu Thr Asp Asn Asn Leu Gly Gln Arg Leu Phe Gly Glu Thr
            1140                1145                1150        
Ile Leu Gly Leu Thr Gln Gly Ser Val Ser Asp Leu Leu Ala Arg Pro
        1155                1160                1165            
Lys Pro Trp His Lys Leu Ser Leu Lys Gly Arg Glu Pro Phe Val Arg
    1170                1175                1180                
Met Gln Leu Trp Leu Asn Asp Pro Asn Asn Val Glu Lys Leu Met Asp
1185                1190                1195                1200
Met Lys Arg Met Glu Lys Lys Ala Tyr Met Lys Arg Arg His Ser Ser
                1205                1210                1215    
Val Ser Asp Ser Gln Pro Cys Glu Pro Pro Ser Val Gly Thr Glu Tyr
            1220                1225                1230        
Ser Gln Gly Ala Ser Pro Gln Pro Gln His Gln Leu Lys Lys Pro Arg
        1235                1240                1245            
Val Val Leu Ala Pro Glu Glu Lys Glu Ala Leu Lys Arg Ala Tyr Gln
    1250                1255                1260                
Gln Lys Pro Tyr Pro Ser Pro Lys Thr Ile Glu Asp Leu Ala Thr Gln
1265                1270                1275                1280
Leu Asn Leu Lys Thr Ser Thr Val Ile Asn Trp Phe His Asn Tyr Arg
                1285                1290                1295    
Ser Arg Ile Arg Arg Glu Leu Phe Ile Glu Glu Ile Gln Ala Gly Ser
            1300                1305                1310        
Gln Gly Gln Ala Gly Ala Ser Asp Ser Pro Ser Ala Arg Ser Gly Arg
        1315                1320                1325            
Ala Ala Pro Ser Ser Glu Gly Asp Ser Cys Asp Gly Val Glu Ala Thr
    1330                1335                1340                
Glu Gly Pro Gly Ser Ala Asp Thr Glu Glu Pro Lys Ser Gln Gly Glu
1345                1350                1355                1360
Ala Glu Arg Glu Glu Val Pro Arg Pro Ala Glu Gln Thr Glu Pro Pro
                1365                1370                1375    
Pro Ser Gly Thr Pro Gly Pro Asp Asp Ala Arg Asp Asp Asp His Glu
            1380                1385                1390        
Gly Gly Pro Val Glu Gly Pro Gly Pro Leu Pro Ser Pro Ala Ser Ala
        1395                1400                1405            
Thr Ala Thr Ala Ala Pro Ala Ala Pro Glu Asp Ala Ala Thr Ser Ala
    1410                1415                1420                
Ala Ala Ala Pro Gly Glu Gly Pro Ala Ala Pro Thr Ser Ala Pro Pro
1425                1430                1435                1440
Pro Ser Asn Ser Ser Ser Ser Ser Ala Pro Arg Arg Pro Ser Ser Leu
                1445                1450                1455    
Gln Ser Leu Phe Gly Leu Pro Glu Ala Ala Gly Ala Arg Asp Ser Arg
            1460                1465                1470        
Asp Asn Pro Leu Arg Lys Lys Lys Ala Ala Asn Leu Asn Ser Ile Ile
        1475                1480                1485            
His Arg Leu Glu Lys Ala Ala Ser Arg Glu Glu Pro Ile Glu Trp Glu
    1490                1495                1500                
Phe
1505


<210> 9323
<211> 555
<212> PRT
<213> Homo sapiens

<400> 9323
Ala Leu His Pro Cys Cys Phe Cys Phe Glu Gly Gly Gly Ser Met Leu
 1               5                  10                  15      
Ser Pro Gln Arg Val Ala Ala Ala Ala Ser Arg Gly Ala Asp Asp Ala
            20                  25                  30          
Met Glu Ser Ser Lys Pro Gly Pro Val Gln Val Val Leu Val Gln Lys
        35                  40                  45              
Asp Gln His Ser Phe Glu Leu Asp Glu Lys Ala Leu Ala Ser Ile Leu
    50                  55                  60                  
Leu Gln Asp His Ile Arg Asp Leu Asp Val Val Val Val Ser Val Ala
65                  70                  75                  80  
Gly Ala Phe Arg Lys Gly Lys Ser Phe Ile Leu Asp Phe Met Leu Arg
                85                  90                  95      
Tyr Leu Tyr Ser Gln Lys Glu Ser Gly His Ser Asn Trp Leu Gly Asp
            100                 105                 110         
Pro Glu Glu Pro Leu Thr Gly Phe Ser Trp Arg Gly Gly Ser Asp Pro
        115                 120                 125             
Glu Thr Thr Gly Ile Gln Ile Trp Ser Glu Val Phe Thr Val Glu Lys
    130                 135                 140                 
Pro Gly Gly Lys Lys Val Ala Val Val Leu Met Asp Thr Gln Gly Ala
145                 150                 155                 160 
Phe Asp Ser Gln Ser Thr Val Lys Asp Cys Ala Ala Ile Phe Ala Leu
                165                 170                 175     
Ser Thr Met Thr Ser Ser Val Gln Ile Tyr Asn Leu Ser Gln Asn Ile
            180                 185                 190         
Gln Glu Asp Asp Leu Gln Gln Leu Gln Leu Phe Thr Glu Tyr Gly Arg
        195                 200                 205             
Leu Ala Met Asp Glu Ile Phe Arg Lys Pro Phe Gln Thr Leu Met Phe
    210                 215                 220                 
Leu Val Arg Asp Arg Ser Phe Pro Tyr Glu Tyr Ser Tyr Gly Leu Gln
225                 230                 235                 240 
Gly Gly Met Ala Phe Leu Asp Lys Arg Leu Gln Val Lys Glu His Gln
                245                 250                 255     
His Glu Glu Ile Gln Asn Val Arg Asn His Ile His Ser Cys Phe Ser
            260                 265                 270         
Asp Val Thr Cys Phe Leu Leu Pro His Pro Gly Leu Gln Val Ala Thr
        275                 280                 285             
Ser Pro Asp Phe Asp Gly Lys Leu Lys Asp Ile Ala Gly Glu Phe Lys
    290                 295                 300                 
Glu Gln Leu Gln Ala Leu Ile Pro Tyr Val Leu Asn Pro Ser Lys Leu
305                 310                 315                 320 
Met Glu Lys Glu Ile Asn Gly Ser Lys Val Thr Cys Arg Gly Leu Leu
                325                 330                 335     
Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr Gln Gly Glu Asp Leu Pro
            340                 345                 350         
His Pro Lys Ser Met Leu Gln Ala Thr Ala Glu Ala Tyr Asn Leu Ala
        355                 360                 365             
Ala Ala Ala Ser Ala Lys Asp Ile Tyr Tyr Asn Asn Met Glu Glu Val
    370                 375                 380                 
Cys Gly Gly Glu Lys Pro Tyr Leu Ser Pro Asp Ile Leu Glu Glu Lys
385                 390                 395                 400 
His Cys Glu Phe Lys Gln Leu Ala Leu Asp His Phe Lys Lys Thr Lys
                405                 410                 415     
Lys Met Gly Gly Lys Asp Phe Ser Phe Arg Tyr Gln Gln Glu Leu Glu
            420                 425                 430         
Glu Glu Ile Lys Glu Leu Tyr Glu Asn Phe Cys Lys His Asn Gly Ser
        435                 440                 445             
Lys Asn Val Phe Ser Thr Phe Arg Thr Pro Ala Val Leu Phe Thr Gly
    450                 455                 460                 
Ile Val Ala Leu Tyr Ile Ala Ser Gly Leu Thr Gly Phe Ile Gly Leu
465                 470                 475                 480 
Glu Val Val Ala Gln Leu Phe Asn Cys Met Val Gly Leu Leu Leu Ile
                485                 490                 495     
Ala Leu Leu Thr Trp Gly Tyr Ile Arg Tyr Ser Gly Gln Tyr Arg Glu
            500                 505                 510         
Leu Gly Gly Ala Ile Asp Phe Gly Ala Ala Tyr Val Leu Glu Gln Ala
        515                 520                 525             
Ser Ser His Ile Gly Asn Ser Thr Gln Ala Thr Val Arg Asp Ala Val
    530                 535                 540                 
Val Gly Arg Pro Ser Met Asp Lys Lys Ala Gln
545                 550                 555 


<210> 9324
<211> 567
<212> PRT
<213> Homo sapiens

<400> 9324
Met Arg Thr Ala Gly Arg Asp Pro Val Ser Ala Gly Leu Gln Phe Pro
 1               5                  10                  15      
Lys Asp Gly Ser Thr Gln Arg Pro Ala Asn Arg Ala Arg Phe Val Pro
            20                  25                  30          
Ala Arg Thr Arg Pro Ser Pro Leu His Pro Cys Cys Phe Cys Phe Glu
        35                  40                  45              
Gly Gly Gly Ser Met Leu Ser Pro Gln Arg Val Ala Ala Ala Ala Ser
    50                  55                  60                  
Arg Gly Ala Asp Asp Ala Met Glu Ser Ser Ile Leu Leu Gln Asp His
65                  70                  75                  80  
Ile Arg Asp Leu Asp Val Val Val Val Ser Val Ala Gly Ala Phe Arg
                85                  90                  95      
Lys Gly Lys Ser Phe Ile Leu Asp Phe Met Leu Arg Tyr Leu Tyr Ser
            100                 105                 110         
Gln Lys Glu Ser Gly His Ser Asn Trp Leu Gly Asp Pro Glu Glu Pro
        115                 120                 125             
Leu Thr Gly Phe Ser Trp Arg Gly Gly Ser Asp Pro Glu Thr Thr Gly
    130                 135                 140                 
Ile Gln Ile Trp Ser Glu Val Phe Thr Val Glu Lys Pro Gly Gly Lys
145                 150                 155                 160 
Lys Val Ala Val Val Leu Met Asp Thr Gln Gly Ala Phe Asp Ser Gln
                165                 170                 175     
Ser Thr Val Lys Asp Cys Ala Thr Ile Phe Ala Leu Ser Thr Met Thr
            180                 185                 190         
Ser Ser Val Gln Ile Tyr Ser Leu Ser Gln Asn Ile Gln Glu Asp Asp
        195                 200                 205             
Leu Gln Gln Leu Gln Leu Phe Thr Glu Tyr Gly Arg Leu Ala Met Asp
    210                 215                 220                 
Glu Ile Phe Gln Lys Pro Phe Gln Thr Leu Met Phe Leu Val Arg Asp
225                 230                 235                 240 
Trp Ser Phe Pro Tyr Glu Tyr Ser Tyr Gly Leu Gln Gly Gly Met Ala
                245                 250                 255     
Phe Leu Asp Lys Arg Leu Gln Val Lys Glu His Gln His Glu Glu Ile
            260                 265                 270         
Gln Asn Val Arg Asn His Ile His Ser Cys Phe Ser Asp Val Thr Cys
        275                 280                 285             
Phe Leu Leu Pro His Pro Gly Leu Gln Val Ala Thr Ser Pro Asp Phe
    290                 295                 300                 
Asp Gly Lys Leu Lys Asp Ile Ala Gly Glu Phe Lys Glu Gln Leu Gln
305                 310                 315                 320 
Ala Leu Ile Pro Tyr Val Leu Asn Pro Ser Lys Leu Met Glu Lys Glu
                325                 330                 335     
Ile Asn Gly Ser Lys Val Thr Cys Arg Gly Leu Leu Glu Tyr Phe Lys
            340                 345                 350         
Ala Tyr Ile Lys Ile Tyr Gln Gly Glu Asp Leu Pro His Pro Lys Ser
        355                 360                 365             
Met Leu Gln Ala Thr Ala Glu Ala Asn Asn Leu Ala Ala Ala Ala Ser
    370                 375                 380                 
Ala Lys Asp Ile Tyr Tyr Asn Asn Met Glu Glu Val Cys Gly Gly Glu
385                 390                 395                 400 
Lys Pro Tyr Leu Ser Pro Asp Ile Leu Glu Glu Lys His Cys Glu Phe
                405                 410                 415     
Lys Gln Leu Ala Leu Asp His Phe Lys Lys Thr Lys Lys Met Gly Gly
            420                 425                 430         
Lys Asp Phe Ser Phe Arg Tyr Gln Gln Glu Leu Glu Glu Glu Ile Lys
        435                 440                 445             
Glu Leu Tyr Glu Asn Phe Cys Lys His Asn Gly Ser Lys Asn Val Phe
    450                 455                 460                 
Ser Thr Phe Arg Thr Pro Ala Val Leu Phe Thr Gly Ile Val Ala Leu
465                 470                 475                 480 
Tyr Ile Ala Ser Gly Leu Thr Gly Phe Ile Gly Leu Glu Val Val Ala
                485                 490                 495     
Gln Leu Phe Asn Cys Met Val Gly Leu Leu Leu Ile Ala Leu Leu Thr
            500                 505                 510         
Trp Gly Tyr Ile Arg Tyr Ser Gly Gln Tyr Arg Glu Leu Gly Gly Ala
        515                 520                 525             
Ile Asp Phe Gly Ala Ala Tyr Val Leu Glu Gln Ala Ser Ser His Ile
    530                 535                 540                 
Gly Asn Ser Thr Gln Ala Thr Val Arg Asp Ala Val Val Gly Arg Pro
545                 550                 555                 560 
Ser Met Asp Lys Lys Ala Gln
                565         


<210> 9325
<211> 862
<212> PRT
<213> Homo sapiens

<400> 9325
Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys
 1               5                  10                  15      
Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala
            20                  25                  30          
Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg
        35                  40                  45              
Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His
    50                  55                  60                  
Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr
65                  70                  75                  80  
Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp
                85                  90                  95      
Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg
            100                 105                 110         
Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser
        115                 120                 125             
Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr
    130                 135                 140                 
Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala
145                 150                 155                 160 
Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser
                165                 170                 175     
Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe
            180                 185                 190         
Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg
        195                 200                 205             
Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys
    210                 215                 220                 
Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser
225                 230                 235                 240 
Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp
                245                 250                 255     
Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu
            260                 265                 270         
Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala
        275                 280                 285             
Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly
    290                 295                 300                 
Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu
305                 310                 315                 320 
Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro
                325                 330                 335     
Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg
            340                 345                 350         
Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys
        355                 360                 365             
Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr
    370                 375                 380                 
Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp
385                 390                 395                 400 
Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu
                405                 410                 415     
Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe
            420                 425                 430         
Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr
        435                 440                 445             
Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser
    450                 455                 460                 
Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg
465                 470                 475                 480 
Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu
                485                 490                 495     
Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln
            500                 505                 510         
Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp
        515                 520                 525             
Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe
    530                 535                 540                 
Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser
545                 550                 555                 560 
Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys
                565                 570                 575     
Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys
            580                 585                 590         
Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu
        595                 600                 605             
Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu
    610                 615                 620                 
Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly
625                 630                 635                 640 
Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu
                645                 650                 655     
Trp Leu Ser Leu Phe Leu His Ala Gly Gln Val Thr Leu Trp Ala Gly
            660                 665                 670         
Ile Leu His Cys Leu Val Ser Ile Cys Phe Gln Met Thr Val Leu Arg
        675                 680                 685             
Asp Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Tyr Leu
    690                 695                 700                 
Leu Ser Gly Val Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr
705                 710                 715                 720 
Arg Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Ile Leu Ala Cys
                725                 730                 735     
Leu Phe Val Glu Leu Phe Gln Ser Trp Gln Ile Leu Ala Arg Pro Trp
            740                 745                 750         
Arg Ala Phe Phe Lys Leu Leu Ala Val Val Leu Phe Leu Phe Thr Phe
        755                 760                 765             
Gly Leu Leu Pro Trp Ile Asp Asn Phe Ala His Ile Ser Gly Phe Ile
    770                 775                 780                 
Ser Gly Leu Phe Leu Ser Phe Ala Phe Leu Pro Tyr Ile Ser Phe Gly
785                 790                 795                 800 
Lys Phe Asp Leu Tyr Arg Lys Arg Cys Gln Ile Ile Ile Phe Gln Val
                805                 810                 815     
Val Phe Leu Gly Leu Leu Ala Gly Leu Val Val Leu Phe Tyr Val Tyr
            820                 825                 830         
Pro Val Arg Cys Glu Trp Cys Glu Phe Leu Thr Cys Ile Pro Phe Thr
        835                 840                 845             
Asp Lys Phe Cys Glu Lys Tyr Glu Leu Asp Ala Gln Leu His
    850                 855                 860         


<210> 9326
<211> 855
<212> PRT
<213> Homo sapiens

<400> 9326
Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys
 1               5                  10                  15      
Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala
            20                  25                  30          
Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg
        35                  40                  45              
Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His
    50                  55                  60                  
Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr
65                  70                  75                  80  
Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp
                85                  90                  95      
Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg
            100                 105                 110         
Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser
        115                 120                 125             
Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr
    130                 135                 140                 
Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala
145                 150                 155                 160 
Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser
                165                 170                 175     
Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe
            180                 185                 190         
Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg
        195                 200                 205             
Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys
    210                 215                 220                 
Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser
225                 230                 235                 240 
Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp
                245                 250                 255     
Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu
            260                 265                 270         
Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala
        275                 280                 285             
Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly
    290                 295                 300                 
Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu
305                 310                 315                 320 
Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro
                325                 330                 335     
Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg
            340                 345                 350         
Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys
        355                 360                 365             
Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr
    370                 375                 380                 
Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp
385                 390                 395                 400 
Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu
                405                 410                 415     
Val Ala Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe
            420                 425                 430         
Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr
        435                 440                 445             
Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser
    450                 455                 460                 
Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg
465                 470                 475                 480 
Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu
                485                 490                 495     
Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln
            500                 505                 510         
Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp
        515                 520                 525             
Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe
    530                 535                 540                 
Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser
545                 550                 555                 560 
Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys
                565                 570                 575     
Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys
            580                 585                 590         
Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu
        595                 600                 605             
Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu
    610                 615                 620                 
Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly
625                 630                 635                 640 
Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu
                645                 650                 655     
Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser
            660                 665                 670         
Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly
        675                 680                 685             
Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn
    690                 695                 700                 
Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala
705                 710                 715                 720 
Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln
                725                 730                 735     
Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu
            740                 745                 750         
Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp
        755                 760                 765             
Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe
    770                 775                 780                 
Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys
785                 790                 795                 800 
Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala
                805                 810                 815     
Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys
            820                 825                 830         
Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr
        835                 840                 845             
Glu Leu Asp Ala Gln Leu His
    850                 855 


<210> 9327
<211> 466
<212> PRT
<213> Homo sapiens

<400> 9327
Met Ala Glu Ala Glu Gly Val Pro Thr Thr Pro Gly Pro Ala Ser Gly
 1               5                  10                  15      
Ser Thr Phe Arg Gly Arg Arg Asp Val Ser Gly Ser Trp Glu Arg Asp
            20                  25                  30          
Gln Gln Val Glu Ala Ala Gln Arg Ala Leu Val Glu Val Leu Gly Pro
        35                  40                  45              
Tyr Glu Pro Leu Leu Ser Arg Val Gln Ala Ala Leu Val Trp Glu Arg
    50                  55                  60                  
Pro Ala Arg Ser Ala Leu Trp Cys Leu Gly Leu Asn Ala Ala Phe Trp
65                  70                  75                  80  
Phe Phe Ala Leu Thr Ser Leu Arg Leu Val Phe Leu Leu Ala Phe Gly
                85                  90                  95      
Leu Met Ile Ile Val Cys Ile Asp Gln Trp Lys Asn Lys Ile Trp Pro
            100                 105                 110         
Glu Ile Lys Val Pro Arg Pro Asp Ala Leu Asp Asn Glu Ser Trp Gly
        115                 120                 125             
Phe Val His Pro Arg Leu Leu Ser Val Pro Glu Leu Cys His His Val
    130                 135                 140                 
Ala Glu Val Trp Val Ser Gly Thr Ile Phe Ile Arg Asn Val Leu Leu
145                 150                 155                 160 
Phe Lys Lys Gln Asn Pro Gly Lys Phe Cys Leu Leu Ser Cys Gly Ile
                165                 170                 175     
Leu Thr Phe Leu Ala Val Leu Gly Arg Tyr Val Pro Gly Leu Leu Leu
            180                 185                 190         
Ser Tyr Leu Met Leu Val Thr Val Met Met Trp Pro Leu Ala Val Tyr
        195                 200                 205             
His Arg Leu Trp Asp Arg Ala Tyr Val Arg Leu Lys Pro Ala Leu Gln
    210                 215                 220                 
Arg Leu Asp Phe Ser Val Arg Gly Tyr Met Met Ser Lys Gln Arg Glu
225                 230                 235                 240 
Arg Gln Leu Arg Arg Arg Ala Leu His Pro Glu Arg Ala Met Asp Asn
                245                 250                 255     
His Ser Asp Ser Glu Glu Glu Leu Ala Ala Phe Cys Pro Gln Leu Asp
            260                 265                 270         
Asp Ser Thr Val Ala Arg Glu Leu Ala Ile Thr Asp Ser Glu His Ser
        275                 280                 285             
Asp Ala Glu Val Ser Cys Thr Asp Asn Gly Thr Phe Asn Leu Ser Arg
    290                 295                 300                 
Gly Gln Thr Pro Leu Thr Glu Gly Ser Glu Asp Leu Asp Gly His Ser
305                 310                 315                 320 
Asp Pro Glu Glu Ser Phe Ala Arg Asp Leu Pro Asp Phe Pro Ser Ile
                325                 330                 335     
Asn Met Asp Pro Ala Gly Leu Asp Asp Glu Asp Asp Thr Ser Ile Gly
            340                 345                 350         
Met Pro Ser Leu Met Tyr Arg Ser Pro Pro Gly Ala Glu Glu Pro Gln
        355                 360                 365             
Ala Pro Pro Ala Ser Arg Asp Glu Ala Ala Leu Pro Glu Leu Leu Leu
    370                 375                 380                 
Gly Ala Leu Pro Val Gly Ser Asn Leu Thr Ser Asn Leu Ala Ser Leu
385                 390                 395                 400 
Val Ser Gln Gly Met Ile Gln Leu Ala Leu Ser Gly Ala Ser Gln Pro
                405                 410                 415     
Gly Pro Ser Gly Ala Pro Ala Gln Arg Ala Thr Arg Gly Phe Leu Arg
            420                 425                 430         
Ser Pro Ser Ser Asp Leu Asp Thr Asp Ala Glu Gly Asp Asp Phe Glu
        435                 440                 445             
Leu Leu Asp Gln Ser Glu Leu Ser Gln Leu Asp Pro Ala Ser Ser Arg
    450                 455                 460                 
Ser His
465     


<210> 9328
<211> 584
<212> PRT
<213> Homo sapiens

<400> 9328
Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser Ile Ser
 1               5                  10                  15      
Asp Leu Leu Gly Leu Gly Asn Ile Trp Ala Val Arg Gly Ile Ser Val
            20                  25                  30          
Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val Lys Trp
        35                  40                  45              
Ile Ile Cys Leu Gln Leu Leu Leu Leu Phe Leu Leu Ala Val Ser Thr
    50                  55                  60                  
Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Glu His Gly
65                  70                  75                  80  
Phe Ile Gly Tyr Ser Pro Glu Leu Leu Gln Asn Asn Thr Leu Pro Asp
                85                  90                  95      
Tyr Ser Pro Gly Glu Ser Phe Phe Thr Val Phe Gly Val Phe Phe Pro
            100                 105                 110         
Ala Ala Thr Gly Val Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg
        115                 120                 125             
Glu Pro Ala Ala Ser Ile Pro Leu Gly Ser Leu Ala Ala Val Gly Ile
    130                 135                 140                 
Ser Trp Phe Leu Tyr Ile Val Phe Val Phe Leu Leu Gly Ala Ile Cys
145                 150                 155                 160 
Thr Arg Glu Ala Leu Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser
                165                 170                 175     
Leu Met Gly Phe Leu Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala
            180                 185                 190         
Ser Cys Met Gly Gly Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile
        195                 200                 205             
Ala Gln Glu Lys Val Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Lys
    210                 215                 220                 
Gly Pro Asn Lys Thr Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val
225                 230                 235                 240 
Thr Met Ala Phe Val Phe Val Gly Gln Val Asn Val Leu Ala Pro Ile
                245                 250                 255     
Val Thr Ile Asn Phe Met Leu Thr Tyr Val Ala Val Asp Tyr Ser Tyr
            260                 265                 270         
Phe Ser Leu Ser Met Cys Ser Cys Ser Leu Thr Pro Val Pro Glu Pro
        275                 280                 285             
Val Leu Arg Glu Gly Ala Glu Gly Leu His Cys Ser Glu His Leu Leu
    290                 295                 300                 
Leu Glu Lys Ala Pro Ser Tyr Gly Ser Glu Gly Pro Ala Gln Arg Val
305                 310                 315                 320 
Leu Glu Gly Thr Leu Leu Glu Phe Thr Lys Asp Met Asp Gln Leu Leu
                325                 330                 335     
Gln Leu Thr Arg Ser Leu Arg Val Ala Ser Pro Gly Lys Glu Arg Val
            340                 345                 350         
Thr Gly Pro Gln Lys Val Arg Arg Gly Lys Ala Arg Arg Pro Pro Ser
        355                 360                 365             
Arg Pro Tyr Lys Ile Ala Ser Ser Trp Thr Ser Asn Pro Leu Leu Leu
    370                 375                 380                 
Ser Leu Ser Arg Ser Leu Thr Gly Cys Pro Leu Pro Pro Gly Arg Gly
385                 390                 395                 400 
Arg Ser Pro Ala Gly Thr Ser Arg Leu Pro Arg Ala Lys Gly Leu Ser
                405                 410                 415     
Leu Arg Glu His Met Glu Ser Asn Leu Phe Leu Ser Cys Ala Thr Asn
            420                 425                 430         
Gln Ser Pro Val Glu Lys Asp Phe Phe Leu Lys Ser Arg Leu Gln Glu
        435                 440                 445             
Gln Asp Val Trp Arg Arg Ser Thr Ser Phe Tyr Thr His Met Cys Asn
    450                 455                 460                 
Pro Trp Val Ser Leu Leu Gly Ala Val Gly Ser Leu Leu Ile Met Phe
465                 470                 475                 480 
Val Ile Gln Trp Val Tyr Thr Leu Val Asn Met Gly Val Ala Ala Ile
                485                 490                 495     
Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro Gly Leu His Leu Gly Ser
            500                 505                 510         
Ala Ser Asn Phe Ser Phe Phe Arg Trp Met Arg Ser Leu Leu Leu Pro
        515                 520                 525             
Ser Cys Arg Ser Leu Gln Ser Pro Gln Glu Gln Ile Ile Leu Ala Pro
    530                 535                 540                 
Ser Leu Ala Lys Val Asp Met Glu Met Thr Gln Leu Thr Gln Glu Asn
545                 550                 555                 560 
Ala Asp Phe Ala Thr Arg Asp Arg Tyr His His Ser Ser Leu Val Asn
                565                 570                 575     
Arg Glu Gln Leu Met Pro His Tyr
            580                 


<210> 9329
<211> 1447
<212> PRT
<213> Homo sapiens

<400> 9329
Met Glu Asn Ser Leu Arg Cys Val Trp Val Pro Lys Leu Ala Phe Val
 1               5                  10                  15      
Leu Phe Gly Ala Ser Leu Leu Ser Ala His Leu Gln Val Thr Gly Phe
            20                  25                  30          
Gln Ile Lys Ala Phe Thr Ala Leu Arg Phe Leu Ser Glu Pro Ser Asp
        35                  40                  45              
Ala Val Thr Met Arg Gly Gly Asn Val Leu Leu Asp Cys Ser Ala Glu
    50                  55                  60                  
Ser Asp Arg Gly Val Pro Val Ile Lys Trp Lys Lys Asp Gly Ile His
65                  70                  75                  80  
Leu Ala Leu Gly Met Asp Glu Arg Lys Gln Gln Leu Ser Asn Gly Ser
                85                  90                  95      
Leu Leu Ile Gln Asn Ile Leu His Ser Arg His His Lys Pro Asp Glu
            100                 105                 110         
Gly Leu Tyr Gln Cys Glu Ala Ser Leu Gly Asp Ser Gly Ser Ile Ile
        115                 120                 125             
Ser Arg Thr Ala Lys Val Ala Val Ala Gly Pro Leu Arg Phe Leu Ser
    130                 135                 140                 
Gln Thr Glu Ser Val Thr Ala Phe Met Gly Asp Thr Val Leu Leu Lys
145                 150                 155                 160 
Cys Glu Val Ile Gly Glu Pro Met Pro Thr Ile His Trp Gln Lys Asn
                165                 170                 175     
Gln Gln Asp Leu Thr Pro Ile Pro Gly Asp Ser Arg Val Val Val Leu
            180                 185                 190         
Pro Ser Gly Ala Leu Gln Ile Ser Arg Leu Gln Pro Gly Asp Ile Gly
        195                 200                 205             
Ile Tyr Arg Cys Ser Ala Arg Asn Pro Ala Ser Ser Arg Thr Gly Asn
    210                 215                 220                 
Glu Ala Glu Val Arg Ile Leu Ser Asp Pro Gly Leu His Arg Gln Leu
225                 230                 235                 240 
Tyr Phe Leu Gln Arg Pro Ser Asn Val Val Ala Ile Glu Gly Lys Asp
                245                 250                 255     
Ala Val Leu Glu Cys Cys Val Ser Gly Tyr Pro Pro Pro Ser Phe Thr
            260                 265                 270         
Trp Leu Arg Gly Glu Glu Val Ile Gln Leu Arg Ser Lys Lys Tyr Ser
        275                 280                 285             
Leu Leu Gly Gly Ser Asn Leu Leu Ile Ser Asn Val Thr Asp Asp Asp
    290                 295                 300                 
Ser Gly Met Tyr Thr Cys Val Val Thr Tyr Lys Asn Glu Asn Ile Ser
305                 310                 315                 320 
Ala Ser Ala Glu Leu Thr Val Leu Val Pro Pro Trp Phe Leu Asn His
                325                 330                 335     
Pro Ser Asn Leu Tyr Ala Tyr Glu Ser Met Asp Ile Glu Phe Glu Cys
            340                 345                 350         
Thr Val Ser Gly Lys Pro Val Pro Thr Val Asn Trp Met Lys Asn Gly
        355                 360                 365             
Asp Val Val Ile Pro Ser Asp Tyr Phe Gln Ile Val Gly Gly Ser Asn
    370                 375                 380                 
Leu Arg Ile Leu Gly Val Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys
385                 390                 395                 400 
Val Ala Glu Asn Glu Ala Gly Asn Ala Gln Thr Ser Ala Gln Leu Ile
                405                 410                 415     
Val Pro Lys Pro Ala Ile Pro Ser Ser Ser Val Leu Pro Ser Ala Pro
            420                 425                 430         
Arg Asp Val Val Pro Val Leu Val Ser Ser Arg Phe Val Arg Leu Ser
        435                 440                 445             
Trp Arg Pro Pro Ala Glu Ala Lys Gly Asn Ile Gln Thr Phe Thr Val
    450                 455                 460                 
Phe Phe Ser Arg Glu Gly Asp Asn Arg Glu Arg Ala Leu Asn Thr Thr
465                 470                 475                 480 
Gln Pro Gly Ser Leu Gln Leu Thr Val Gly Asn Leu Lys Pro Glu Ala
                485                 490                 495     
Met Tyr Thr Phe Arg Val Val Ala Tyr Asn Glu Trp Gly Pro Gly Glu
            500                 505                 510         
Ser Ser Gln Pro Ile Lys Val Ala Thr Gln Pro Glu Leu Gln Val Pro
        515                 520                 525             
Gly Pro Val Glu Asn Leu Gln Ala Val Ser Thr Ser Pro Thr Ser Ile
    530                 535                 540                 
Leu Ile Thr Trp Glu Pro Pro Ala Tyr Ala Asn Gly Pro Val Gln Gly
545                 550                 555                 560 
Tyr Arg Leu Phe Cys Thr Glu Val Ser Thr Gly Lys Glu Gln Asn Ile
                565                 570                 575     
Glu Val Asp Gly Leu Ser Tyr Lys Leu Glu Gly Leu Lys Lys Phe Thr
            580                 585                 590         
Glu Tyr Ser Leu Arg Phe Leu Ala Tyr Asn Arg Tyr Gly Pro Gly Val
        595                 600                 605             
Ser Thr Asp Asp Ile Thr Val Val Thr Leu Ser Asp Val Pro Ser Ala
    610                 615                 620                 
Pro Pro Gln Asn Val Ser Leu Glu Val Val Asn Ser Arg Ser Ile Lys
625                 630                 635                 640 
Val Ser Trp Leu Pro Pro Pro Ser Gly Thr Gln Asn Gly Phe Ile Thr
                645                 650                 655     
Gly Tyr Lys Ile Arg His Arg Lys Thr Thr Arg Arg Gly Glu Met Glu
            660                 665                 670         
Thr Leu Glu Pro Asn Asn Leu Trp Tyr Leu Phe Thr Gly Leu Glu Lys
        675                 680                 685             
Gly Ser Gln Tyr Ser Phe Gln Val Ser Ala Met Thr Val Asn Gly Thr
    690                 695                 700                 
Gly Pro Pro Ser Asn Trp Tyr Thr Ala Glu Thr Pro Glu Asn Asp Leu
705                 710                 715                 720 
Asp Glu Ser Gln Val Pro Asp Gln Pro Ser Ser Leu His Val Arg Pro
                725                 730                 735     
Gln Thr Asn Cys Ile Ile Met Ser Trp Thr Pro Pro Leu Asn Pro Asn
            740                 745                 750         
Ile Val Val Arg Gly Tyr Ile Ile Gly Tyr Gly Val Gly Ser Pro Tyr
        755                 760                 765             
Ala Glu Thr Val Arg Val Asp Ser Lys Gln Arg Tyr Tyr Ser Ile Glu
    770                 775                 780                 
Arg Leu Glu Ser Ser Ser His Tyr Val Ile Ser Leu Lys Ala Phe Asn
785                 790                 795                 800 
Asn Ala Gly Glu Gly Val Pro Leu Tyr Glu Ser Ala Thr Thr Arg Ser
                805                 810                 815     
Ile Thr Asp Pro Thr Asp Pro Val Asp Tyr Tyr Pro Leu Leu Asp Asp
            820                 825                 830         
Phe Pro Thr Ser Val Pro Asp Leu Ser Thr Pro Met Leu Pro Pro Val
        835                 840                 845             
Gly Val Gln Ala Val Ala Leu Thr His Asp Ala Val Arg Val Ser Trp
    850                 855                 860                 
Ala Asp Asn Ser Val Pro Lys Asn Gln Lys Thr Ser Glu Val Arg Leu
865                 870                 875                 880 
Tyr Thr Val Arg Trp Arg Thr Ser Phe Ser Ala Ser Ala Lys Tyr Lys
                885                 890                 895     
Ser Glu Asp Thr Thr Ser Leu Ser Tyr Thr Ala Thr Gly Leu Lys Pro
            900                 905                 910         
Asn Thr Met Tyr Glu Phe Ser Val Met Val Thr Lys Asn Arg Arg Ser
        915                 920                 925             
Ser Thr Trp Ser Met Thr Ala His Ala Thr Thr Tyr Glu Ala Ala Pro
    930                 935                 940                 
Thr Ser Ala Pro Lys Asp Phe Thr Val Ile Thr Arg Glu Gly Lys Pro
945                 950                 955                 960 
Arg Ala Val Ile Val Ser Trp Gln Pro Pro Leu Glu Ala Asn Gly Lys
                965                 970                 975     
Ile Thr Ala Tyr Ile Leu Phe Tyr Thr Leu Asp Lys Asn Ile Pro Ile
            980                 985                 990         
Asp Asp Trp Ile Met Glu Thr Ile Ser Gly Asp Arg Leu Thr His Gln
        995                 1000                1005            
Ile Met Asp Leu Asn Leu Asp Thr Met Tyr Tyr Phe Arg Ile Gln Ala
    1010                1015                1020                
Arg Asn Ser Lys Gly Val Gly Pro Leu Ser Asp Pro Ile Leu Phe Arg
1025                1030                1035                1040
Thr Leu Lys Val Glu His Pro Asp Lys Met Ala Asn Asp Gln Gly Arg
                1045                1050                1055    
His Gly Asp Gly Gly Tyr Trp Pro Val Asp Thr Asn Leu Ile Asp Arg
            1060                1065                1070        
Ser Thr Leu Asn Glu Pro Pro Ile Gly Gln Met His Pro Pro His Gly
        1075                1080                1085            
Ser Val Thr Pro Gln Lys Asn Ser Asn Leu Leu Val Ile Ile Val Val
    1090                1095                1100                
Thr Val Gly Val Ile Thr Val Leu Val Val Val Ile Val Ala Val Ile
1105                1110                1115                1120
Cys Thr Arg Arg Ser Ser Ala Gln Gln Arg Lys Lys Arg Ala Thr His
                1125                1130                1135    
Ser Ala Gly Lys Arg Lys Gly Ser Gln Lys Asp Leu Arg Pro Pro Asp
            1140                1145                1150        
Leu Trp Ile His His Glu Glu Met Glu Met Lys Asn Ile Glu Lys Pro
        1155                1160                1165            
Ser Gly Thr Asp Pro Ala Gly Arg Asp Ser Pro Ile Gln Ser Cys Gln
    1170                1175                1180                
Asp Leu Thr Pro Val Ser His Ser Gln Ser Glu Thr Gln Leu Gly Ser
1185                1190                1195                1200
Lys Ser Thr Ser His Ser Gly Gln Asp Thr Glu Glu Ala Gly Ser Ser
                1205                1210                1215    
Met Ser Thr Leu Glu Arg Ser Leu Ala Ala Arg Arg Ala Pro Arg Ala
            1220                1225                1230        
Lys Leu Met Ile Pro Met Asp Ala Gln Ser Asn Asn Pro Ala Val Val
        1235                1240                1245            
Ser Ala Ile Pro Val Pro Thr Leu Glu Ser Ala Gln Tyr Pro Gly Ile
    1250                1255                1260                
Leu Pro Ser Pro Thr Cys Gly Tyr Pro His Pro Gln Phe Thr Leu Arg
1265                1270                1275                1280
Pro Val Pro Phe Pro Thr Leu Ser Val Asp Arg Gly Phe Gly Ala Gly
                1285                1290                1295    
Arg Ser Gln Ser Val Ser Glu Gly Pro Thr Thr Gln Gln Pro Pro Met
            1300                1305                1310        
Leu Pro Pro Ser Gln Pro Glu His Ser Ser Ser Glu Glu Ala Pro Ser
        1315                1320                1325            
Arg Thr Ile Pro Thr Ala Cys Val Arg Pro Thr His Pro Leu Arg Ser
    1330                1335                1340                
Phe Ala Asn Pro Leu Leu Pro Pro Pro Met Ser Ala Ile Glu Pro Lys
1345                1350                1355                1360
Val Pro Tyr Thr Pro Leu Leu Ser Gln Pro Gly Pro Thr Leu Pro Lys
                1365                1370                1375    
Thr His Val Lys Thr Ala Ser Leu Gly Leu Ala Gly Lys Ala Arg Ser
            1380                1385                1390        
Pro Leu Leu Pro Val Ser Val Pro Thr Ala Pro Glu Val Ser Glu Glu
        1395                1400                1405            
Ser His Lys Pro Thr Glu Asp Ser Ala Asn Val Tyr Glu Gln Asp Asp
    1410                1415                1420                
Leu Ser Glu Gln Met Ala Ser Leu Glu Gly Leu Met Lys Gln Leu Asn
1425                1430                1435                1440
Ala Ile Thr Gly Ser Ala Phe
                1445        


<210> 9330
<211> 1132
<212> PRT
<213> Homo sapiens

<400> 9330
Met Gln Arg Arg Gly Ala Gly Leu Gly Trp Pro Arg Gln Gln Gln Gln
 1               5                  10                  15      
Gln Pro Pro Pro Leu Ala Val Gly Pro Arg Ala Ala Ala Met Val Pro
            20                  25                  30          
Ser Gly Gly Val Pro Gln Gly Leu Gly Gly Arg Ser Ala Cys Ala Leu
        35                  40                  45              
Leu Leu Leu Cys Tyr Leu Asn Val Val Pro Ser Leu Gly Arg Gln Thr
    50                  55                  60                  
Ser Leu Thr Thr Ser Val Ile Pro Lys Ala Glu Gln Ser Val Ala Tyr
65                  70                  75                  80  
Lys Asp Phe Ile Tyr Phe Thr Val Phe Glu Gly Asn Val Arg Asn Val
                85                  90                  95      
Ser Glu Val Ser Val Glu Tyr Leu Cys Ser Gln Pro Cys Val Val Asn
            100                 105                 110         
Leu Glu Ala Val Val Ser Ser Glu Phe Arg Ser Ser Ile Pro Val Tyr
        115                 120                 125             
Lys Lys Arg Trp Lys Asn Glu Lys His Leu His Thr Ser Arg Thr Gln
    130                 135                 140                 
Ile Val His Val Lys Phe Pro Ser Ile Met Val Tyr Arg Asp Asp Tyr
145                 150                 155                 160 
Phe Ile Arg His Ser Ile Ser Val Ser Ala Val Ile Val Arg Ala Trp
                165                 170                 175     
Ile Thr His Lys Tyr Ser Gly Arg Asp Trp Asn Val Lys Trp Glu Glu
            180                 185                 190         
Asn Leu Leu His Ala Val Ala Lys Asn Tyr Thr Leu Leu Gln Thr Ile
        195                 200                 205             
Pro Pro Phe Glu Arg Pro Phe Lys Asp His Gln Val Cys Leu Glu Trp
    210                 215                 220                 
Asn Met Gly Tyr Ile Trp Asn Leu Arg Ala Asn Arg Ile Pro Gln Cys
225                 230                 235                 240 
Pro Leu Glu Asn Asp Val Val Ala Leu Leu Gly Phe Pro Tyr Ala Ser
                245                 250                 255     
Ser Gly Glu Asn Thr Gly Ile Val Lys Lys Phe Pro Arg Phe Arg Asn
            260                 265                 270         
Arg Glu Leu Glu Ala Thr Arg Arg Gln Arg Met Asp Tyr Pro Val Phe
        275                 280                 285             
Thr Val Ser Leu Trp Leu Tyr Leu Leu His Tyr Cys Lys Ala Asn Leu
    290                 295                 300                 
Cys Gly Ile Leu Tyr Phe Val Asp Ser Asn Glu Met Tyr Gly Thr Pro
305                 310                 315                 320 
Ser Val Phe Leu Thr Glu Glu Gly Tyr Leu His Ile Gln Met His Leu
                325                 330                 335     
Val Lys Gly Glu Asp Leu Ala Val Lys Thr Lys Phe Ile Ile Pro Leu
            340                 345                 350         
Lys Glu Trp Phe Arg Leu Asp Ile Ser Phe Asn Gly Gly Gln Ile Val
        355                 360                 365             
Val Thr Thr Ser Ile Gly Gln Asp Leu Lys Ser Tyr His Asn Gln Thr
    370                 375                 380                 
Ile Ser Phe Arg Glu Asp Phe His Tyr Asn Asp Thr Ala Gly Tyr Phe
385                 390                 395                 400 
Ile Ile Gly Gly Ser Arg Tyr Val Ala Gly Ile Glu Gly Phe Phe Gly
                405                 410                 415     
Pro Leu Lys Tyr Tyr Arg Leu Arg Ser Leu His Pro Ala Gln Ile Phe
            420                 425                 430         
Asn Pro Leu Leu Glu Lys Gln Leu Ala Glu Gln Ile Lys Leu Tyr Tyr
        435                 440                 445             
Glu Arg Cys Ala Glu Val Gln Glu Ile Val Ser Val Tyr Ala Ser Ala
    450                 455                 460                 
Ala Lys His Gly Gly Glu Arg Gln Glu Ala Cys His Leu His Asn Ser
465                 470                 475                 480 
Tyr Leu Asp Leu Gln Arg Arg Tyr Gly Arg Pro Ser Met Cys Arg Ala
                485                 490                 495     
Phe Pro Trp Glu Lys Glu Leu Lys Asp Lys His Pro Ser Leu Phe Gln
            500                 505                 510         
Ala Leu Leu Glu Met Asp Leu Leu Thr Val Pro Arg Asn Gln Asn Glu
        515                 520                 525             
Ser Val Ser Glu Ile Gly Gly Lys Ile Phe Glu Lys Ala Val Lys Arg
    530                 535                 540                 
Leu Ser Ser Ile Asp Gly Leu His Gln Ile Ser Ser Ile Val Pro Phe
545                 550                 555                 560 
Leu Thr Asp Ser Ser Cys Cys Gly Tyr His Lys Ala Ser Tyr Tyr Leu
                565                 570                 575     
Ala Val Phe Tyr Glu Thr Gly Leu Asn Val Pro Arg Asp Gln Leu Gln
            580                 585                 590         
Gly Met Leu Tyr Ser Leu Val Gly Gly Gln Gly Ser Glu Arg Leu Ser
        595                 600                 605             
Ser Met Asn Leu Gly Tyr Lys His Tyr Gln Gly Ile Asp Asn Tyr Pro
    610                 615                 620                 
Leu Asp Trp Glu Leu Ser Tyr Ala Tyr Tyr Ser Asn Ile Ala Thr Lys
625                 630                 635                 640 
Thr Pro Leu Asp Gln His Thr Leu Gln Gly Asp Gln Ala Tyr Val Glu
                645                 650                 655     
Thr Ile Arg Leu Lys Asp Asp Glu Ile Leu Lys Val Gln Thr Lys Glu
            660                 665                 670         
Asp Gly Asp Val Phe Met Trp Leu Lys His Glu Ala Thr Arg Gly Asn
        675                 680                 685             
Ala Ala Ala Gln Gln Arg Leu Ala Gln Met Leu Phe Trp Gly Gln Gln
    690                 695                 700                 
Gly Val Ala Lys Asn Pro Glu Ala Ala Ile Glu Trp Tyr Ala Lys Gly
705                 710                 715                 720 
Ala Leu Glu Thr Glu Asp Pro Ala Leu Ile Tyr Asp Tyr Ala Ile Val
                725                 730                 735     
Leu Phe Lys Gly Gln Gly Val Lys Lys Asn Arg Arg Leu Ala Leu Glu
            740                 745                 750         
Leu Met Lys Lys Ala Ala Ser Lys Gly Leu His Gln Ala Val Asn Gly
        755                 760                 765             
Leu Gly Trp Tyr Tyr His Lys Phe Lys Lys Asn Tyr Ala Lys Ala Ala
    770                 775                 780                 
Lys Tyr Trp Leu Lys Ala Glu Glu Met Gly Asn Pro Asp Ala Ser Tyr
785                 790                 795                 800 
Asn Leu Gly Val Leu His Leu Asp Gly Ile Phe Pro Gly Val Pro Gly
                805                 810                 815     
Arg Asn Gln Thr Leu Ala Gly Glu Tyr Phe His Lys Ala Ala Gln Gly
            820                 825                 830         
Gly His Met Glu Gly Thr Leu Trp Cys Ser Leu Tyr Tyr Ile Thr Gly
        835                 840                 845             
Asn Leu Glu Thr Phe Pro Arg Asp Pro Glu Lys Ala Val Val Trp Ala
    850                 855                 860                 
Lys His Val Ala Glu Lys Asn Gly Tyr Leu Gly His Val Ile Arg Lys
865                 870                 875                 880 
Gly Leu Asn Ala Tyr Leu Glu Gly Ser Trp His Glu Ala Leu Leu Tyr
                885                 890                 895     
Tyr Val Leu Ala Ala Glu Thr Gly Ile Glu Val Ser Gln Thr Asn Leu
            900                 905                 910         
Ala His Ile Cys Glu Glu Arg Pro Asp Leu Ala Arg Arg Tyr Leu Gly
        915                 920                 925             
Val Asn Cys Val Trp Arg Tyr Tyr Asn Phe Ser Val Phe Gln Ile Asp
    930                 935                 940                 
Ala Pro Ser Phe Ala Tyr Leu Lys Met Gly Asp Leu Tyr Tyr Tyr Gly
945                 950                 955                 960 
His Gln Asn Gln Ser Gln Asp Leu Glu Leu Ser Val Gln Met Tyr Ala
                965                 970                 975     
Gln Ala Ala Leu Asp Gly Asp Ser Gln Gly Phe Phe Asn Leu Ala Leu
            980                 985                 990         
Leu Ile Glu Glu Gly Thr Ile Ile Pro His His Ile Leu Asp Phe Leu
        995                 1000                1005            
Glu Ile Asp Ser Thr Leu His Ser Asn Asn Ile Ser Ile Leu Gln Glu
    1010                1015                1020                
Leu Tyr Glu Arg Cys Trp Ser His Ser Asn Glu Glu Ser Phe Ser Pro
1025                1030                1035                1040
Cys Ser Leu Ala Trp Leu Tyr Leu His Leu Arg Leu Leu Trp Gly Ala
                1045                1050                1055    
Ile Leu His Ser Ala Leu Ile Tyr Phe Leu Gly Thr Phe Leu Leu Ser
            1060                1065                1070        
Ile Leu Ile Ala Trp Thr Val Gln Tyr Phe Gln Ser Val Ser Ala Ser
        1075                1080                1085            
Asp Pro Pro Pro Arg Pro Ser Gln Ala Ser Pro Asp Thr Ala Thr Ser
    1090                1095                1100                
Thr Ala Ser Pro Ala Val Thr Pro Ala Ala Asp Ala Ser Asp Gln Asp
1105                1110                1115                1120
Gln Pro Thr Val Thr Asn Asn Pro Glu Pro Arg Gly
                1125                1130        


<210> 9331
<211> 979
<212> PRT
<213> Homo sapiens

<400> 9331
Met Val Tyr Arg Asp Asp Tyr Phe Ile Arg His Ser Ile Ser Val Ser
 1               5                  10                  15      
Ala Val Ile Val Arg Ala Trp Ile Thr His Lys Tyr Ser Gly Arg Asp
            20                  25                  30          
Trp Asn Val Lys Trp Glu Glu Asn Leu Leu His Ala Val Ala Lys Asn
        35                  40                  45              
Tyr Thr Leu Leu Gln Thr Ile Pro Pro Phe Glu Arg Pro Phe Lys Asp
    50                  55                  60                  
His Gln Val Cys Leu Glu Trp Asn Met Gly Tyr Ile Trp Asn Leu Arg
65                  70                  75                  80  
Ala Asn Arg Ile Pro Gln Cys Pro Leu Glu Asn Asp Val Val Ala Leu
                85                  90                  95      
Leu Gly Phe Pro Tyr Ala Ser Ser Gly Glu Asn Thr Gly Ile Val Lys
            100                 105                 110         
Lys Phe Pro Arg Phe Arg Asn Arg Glu Leu Glu Ala Thr Arg Arg Gln
        115                 120                 125             
Arg Met Asp Tyr Pro Val Phe Thr Val Ser Leu Trp Leu Tyr Leu Leu
    130                 135                 140                 
His Tyr Cys Lys Ala Asn Leu Cys Gly Ile Leu Tyr Phe Val Asp Ser
145                 150                 155                 160 
Asn Glu Met Tyr Gly Thr Pro Ser Val Phe Leu Thr Glu Glu Gly Tyr
                165                 170                 175     
Leu His Ile Gln Met His Leu Val Lys Gly Glu Asp Leu Ala Val Lys
            180                 185                 190         
Thr Lys Phe Ile Ile Pro Leu Lys Glu Trp Phe Arg Leu Asp Ile Ser
        195                 200                 205             
Phe Asn Gly Gly Gln Ile Val Val Thr Thr Ser Ile Gly Gln Asp Leu
    210                 215                 220                 
Lys Ser Tyr His Asn Gln Thr Ile Ser Phe Arg Glu Asp Phe His Tyr
225                 230                 235                 240 
Asn Asp Thr Ala Gly Tyr Phe Ile Ile Gly Gly Ser Arg Tyr Val Ala
                245                 250                 255     
Gly Ile Glu Gly Phe Phe Gly Pro Leu Lys Tyr Tyr Arg Leu Arg Ser
            260                 265                 270         
Leu His Pro Ala Gln Ile Phe Asn Pro Leu Leu Glu Lys Gln Leu Ala
        275                 280                 285             
Glu Gln Ile Lys Leu Tyr Tyr Glu Arg Cys Ala Glu Val Gln Glu Ile
    290                 295                 300                 
Val Ser Val Tyr Ala Ser Ala Ala Lys His Gly Gly Glu Arg Gln Glu
305                 310                 315                 320 
Ala Cys His Leu His Asn Ser Tyr Leu Asp Leu Gln Arg Arg Tyr Gly
                325                 330                 335     
Arg Pro Ser Met Cys Arg Ala Phe Pro Trp Glu Lys Glu Leu Lys Asp
            340                 345                 350         
Lys His Pro Ser Leu Phe Gln Ala Leu Leu Glu Met Asp Leu Leu Thr
        355                 360                 365             
Val Pro Arg Asn Gln Asn Glu Ser Val Ser Glu Ile Gly Gly Lys Ile
    370                 375                 380                 
Phe Glu Lys Ala Val Lys Arg Leu Ser Ser Ile Asp Gly Leu His Gln
385                 390                 395                 400 
Ile Ser Ser Ile Val Pro Phe Leu Thr Asp Ser Ser Cys Cys Gly Tyr
                405                 410                 415     
His Lys Ala Ser Tyr Tyr Leu Ala Val Phe Tyr Glu Thr Gly Leu Asn
            420                 425                 430         
Val Pro Arg Asp Gln Leu Gln Gly Met Leu Tyr Ser Leu Val Gly Gly
        435                 440                 445             
Gln Gly Ser Glu Arg Leu Ser Ser Met Asn Leu Gly Tyr Lys His Tyr
    450                 455                 460                 
Gln Gly Ile Asp Asn Tyr Pro Leu Asp Trp Glu Leu Ser Tyr Ala Tyr
465                 470                 475                 480 
Tyr Ser Asn Ile Ala Thr Lys Thr Pro Leu Asp Gln His Thr Leu Gln
                485                 490                 495     
Gly Asp Gln Ala Tyr Val Glu Thr Ile Arg Leu Lys Asp Asp Glu Ile
            500                 505                 510         
Leu Lys Val Gln Thr Lys Glu Asp Gly Asp Val Phe Met Trp Leu Lys
        515                 520                 525             
His Glu Ala Thr Arg Gly Asn Ala Ala Ala Gln Gln Arg Leu Ala Gln
    530                 535                 540                 
Met Leu Phe Trp Gly Gln Gln Gly Val Ala Lys Asn Pro Glu Ala Ala
545                 550                 555                 560 
Ile Glu Trp Tyr Ala Lys Gly Ala Leu Glu Thr Glu Asp Pro Ala Leu
                565                 570                 575     
Ile Tyr Asp Tyr Ala Ile Val Leu Phe Lys Gly Gln Gly Val Lys Lys
            580                 585                 590         
Asn Arg Arg Leu Ala Leu Glu Leu Met Lys Lys Ala Ala Ser Lys Gly
        595                 600                 605             
Leu His Gln Ala Val Asn Gly Leu Gly Trp Tyr Tyr His Lys Phe Lys
    610                 615                 620                 
Lys Asn Tyr Ala Lys Ala Ala Lys Tyr Trp Leu Lys Ala Glu Glu Met
625                 630                 635                 640 
Gly Asn Pro Asp Ala Ser Tyr Asn Leu Gly Val Leu His Leu Asp Gly
                645                 650                 655     
Ile Phe Pro Gly Val Pro Gly Arg Asn Gln Thr Leu Ala Gly Glu Ile
            660                 665                 670         
Phe His Lys Ala Ala Gln Gly Gly His Met Glu Gly Thr Leu Trp Cys
        675                 680                 685             
Ser Leu Tyr Tyr Ile Thr Gly Asn Leu Glu Thr Phe Pro Arg Asp Pro
    690                 695                 700                 
Glu Lys Ala Val Val Trp Ala Lys His Val Ala Glu Lys Asn Gly Tyr
705                 710                 715                 720 
Leu Gly His Val Ile Arg Lys Gly Leu Asn Ala Tyr Leu Glu Gly Ser
                725                 730                 735     
Trp His Glu Ala Leu Leu Tyr Tyr Val Leu Ala Ala Glu Thr Gly Ile
            740                 745                 750         
Glu Val Ser Gln Thr Asn Leu Ala His Ile Cys Glu Glu Arg Pro Asp
        755                 760                 765             
Leu Ala Arg Arg Tyr Leu Gly Val Asn Cys Val Trp Arg Tyr Tyr Asn
    770                 775                 780                 
Phe Ser Val Phe Gln Ile Asp Ala Pro Ser Phe Ala Tyr Leu Lys Met
785                 790                 795                 800 
Gly Asp Leu Tyr Tyr Tyr Gly His Gln Asn Gln Ser Gln Asp Leu Glu
                805                 810                 815     
Leu Ser Val Gln Met Tyr Ala Gln Ala Ala Leu Asp Gly Asp Ser Gln
            820                 825                 830         
Gly Phe Phe Asn Leu Ala Leu Leu Ile Glu Glu Gly Thr Ile Ile Pro
        835                 840                 845             
His His Ile Leu Asp Phe Leu Glu Ile Asp Ser Thr Leu His Ser Asn
    850                 855                 860                 
Asn Ile Ser Ile Leu Gln Glu Leu Tyr Glu Arg Cys Trp Ser His Ser
865                 870                 875                 880 
Asn Glu Glu Ser Phe Ser Pro Cys Ser Leu Ala Trp Leu Tyr Leu His
                885                 890                 895     
Leu Arg Leu Leu Trp Gly Ala Ile Leu His Ser Ala Leu Ile Tyr Phe
            900                 905                 910         
Leu Gly Thr Phe Leu Leu Ser Ile Leu Ile Ala Trp Thr Val Gln Tyr
        915                 920                 925             
Phe Gln Ser Val Ser Ala Ser Asp Pro Pro Pro Arg Pro Ser Gln Ala
    930                 935                 940                 
Ser Pro Asp Thr Ala Thr Ser Thr Ala Ser Pro Ala Val Thr Pro Ala
945                 950                 955                 960 
Ala Asp Ala Ser Asp Gln Asp Gln Pro Thr Val Thr Asn Asn Pro Glu
                965                 970                 975     
Pro Arg Gly
            


<210> 9332
<211> 1738
<212> PRT
<213> Homo sapiens

<400> 9332
Met Leu Lys Arg Lys Gln Ser Ser Arg Val Glu Ala Gln Pro Val Thr
 1               5                  10                  15      
Asp Phe Gly Pro Asp Glu Ser Leu Ser Asp Asn Ala Asp Ile Leu Trp
            20                  25                  30          
Ile Asn Lys Pro Trp Val His Ser Leu Leu Arg Ile Cys Ala Ile Ile
        35                  40                  45              
Ser Val Ile Ser Val Cys Met Asn Thr Pro Met Thr Phe Glu His Tyr
    50                  55                  60                  
Pro Pro Leu Gln Tyr Val Thr Phe Thr Leu Asp Thr Leu Leu Met Phe
65                  70                  75                  80  
Leu Tyr Thr Ala Glu Met Ile Ala Lys Met His Ile Arg Gly Ile Val
                85                  90                  95      
Lys Gly Asp Ser Ser Tyr Val Lys Asp Arg Trp Cys Val Phe Asp Gly
            100                 105                 110         
Phe Met Val Phe Cys Leu Trp Val Ser Leu Val Leu Gln Val Phe Glu
        115                 120                 125             
Ile Ala Asp Ile Val Asp Gln Met Ser Pro Trp Gly Met Leu Arg Ile
    130                 135                 140                 
Pro Arg Pro Leu Ile Met Ile Arg Ala Phe Arg Ile Tyr Phe Arg Phe
145                 150                 155                 160 
Glu Leu Pro Arg Thr Arg Ile Thr Asn Ile Leu Lys Arg Ser Gly Glu
                165                 170                 175     
Gln Ile Trp Ser Val Ser Ile Phe Leu Leu Phe Phe Leu Leu Leu Tyr
            180                 185                 190         
Gly Ile Leu Gly Val Gln Met Phe Gly Thr Phe Thr Tyr His Cys Val
        195                 200                 205             
Val Asn Asp Thr Lys Pro Gly Asn Val Thr Trp Asn Ser Leu Ala Ile
    210                 215                 220                 
Pro Asp Thr His Cys Ser Pro Glu Leu Glu Glu Gly Tyr Gln Cys Pro
225                 230                 235                 240 
Pro Gly Phe Lys Cys Met Asp Leu Glu Asp Leu Gly Leu Ser Arg Gln
                245                 250                 255     
Glu Leu Gly Tyr Ser Gly Phe Asn Glu Ile Gly Thr Ser Ile Phe Thr
            260                 265                 270         
Val Tyr Glu Ala Ala Ser Gln Glu Gly Trp Val Phe Leu Met Tyr Arg
        275                 280                 285             
Ala Ile Asp Ser Phe Pro Arg Trp Arg Ser Tyr Phe Tyr Phe Ile Thr
    290                 295                 300                 
Leu Ile Phe Phe Leu Ala Trp Leu Val Lys Asn Val Phe Ile Ala Val
305                 310                 315                 320 
Ile Ile Glu Thr Phe Ala Glu Ile Arg Val Gln Phe Gln Gln Met Trp
                325                 330                 335     
Gly Ser Arg Ser Ser Thr Thr Ser Thr Ala Thr Thr Gln Met Phe His
            340                 345                 350         
Glu Asp Ala Ala Gly Gly Trp Gln Leu Val Ala Val Asp Val Asn Lys
        355                 360                 365             
Pro Gln Gly Arg Ala Pro Ala Cys Leu Gln Lys Met Met Arg Ser Ser
    370                 375                 380                 
Val Phe His Met Phe Ile Leu Ser Met Val Thr Val Asp Val Ile Val
385                 390                 395                 400 
Ala Ala Ser Asn Tyr Tyr Lys Gly Glu Asn Phe Arg Arg Gln Tyr Asp
                405                 410                 415     
Glu Phe Tyr Leu Ala Glu Val Ala Phe Thr Val Leu Phe Asp Leu Glu
            420                 425                 430         
Ala Leu Leu Lys Ile Trp Cys Leu Gly Phe Thr Gly Tyr Ile Ser Ser
        435                 440                 445             
Ser Leu His Lys Phe Glu Leu Leu Leu Val Ile Gly Thr Thr Leu His
    450                 455                 460                 
Val Tyr Pro Asp Leu Tyr His Ser Gln Phe Thr Tyr Phe Gln Val Leu
465                 470                 475                 480 
Arg Val Val Arg Leu Ile Lys Ile Ser Pro Ala Leu Glu Asp Phe Val
                485                 490                 495     
Tyr Lys Ile Phe Gly Pro Gly Lys Lys Leu Gly Ser Leu Val Val Phe
            500                 505                 510         
Thr Ala Ser Leu Leu Ile Val Met Ser Ala Ile Ser Leu Gln Met Phe
        515                 520                 525             
Cys Phe Val Glu Glu Leu Asp Arg Phe Thr Thr Phe Pro Arg Ala Phe
    530                 535                 540                 
Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val Met
545                 550                 555                 560 
Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val Ala
                565                 570                 575     
Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu Ser
            580                 585                 590         
Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp Leu
        595                 600                 605             
Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr Lys
    610                 615                 620                 
Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn Arg
625                 630                 635                 640 
Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val Pro
                645                 650                 655     
Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln Gln
            660                 665                 670         
Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser Ser
        675                 680                 685             
Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile Asp
    690                 695                 700                 
Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu Leu
705                 710                 715                 720 
Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg Gln
                725                 730                 735     
Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg Ser
            740                 745                 750         
Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu Arg
        755                 760                 765             
His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu Thr
    770                 775                 780                 
Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln Arg
785                 790                 795                 800 
Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala Glu
                805                 810                 815     
Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro Tyr
            820                 825                 830         
Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg Asn
        835                 840                 845             
Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr Asp
    850                 855                 860                 
Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr Asp
865                 870                 875                 880 
Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val Thr
                885                 890                 895     
Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg Val
            900                 905                 910         
Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile Phe
        915                 920                 925             
Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe Phe
    930                 935                 940                 
Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile Phe
945                 950                 955                 960 
Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn Val
                965                 970                 975     
Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu Arg
            980                 985                 990         
Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val Arg
        995                 1000                1005            
Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu Leu
    1010                1015                1020                
Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe Ala
1025                1030                1035                1040
Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu Asp
                1045                1050                1055    
Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu Asn
            1060                1065                1070        
Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro Arg
        1075                1080                1085            
Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn Ala
    1090                1095                1100                
Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu Val
1105                1110                1115                1120
Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr Ile
                1125                1130                1135    
His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe Val
            1140                1145                1150        
Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu Leu
        1155                1160                1165            
Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys Ile
    1170                1175                1180                
Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe Arg
1185                1190                1195                1200
Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr Ile
                1205                1210                1215    
Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp Asp
            1220                1225                1230        
Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val Phe
        1235                1240                1245            
Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met Ser
    1250                1255                1260                
Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu Val
1265                1270                1275                1280
Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu Asn
                1285                1290                1295    
Ala Tyr Thr Tyr Met Met Gly Ala Cys Val Ile Val Phe Arg Phe Phe
            1300                1305                1310        
Ser Ile Cys Gly Lys His Val Thr Leu Lys Met Leu Leu Leu Thr Val
        1315                1320                1325            
Val Val Ser Met Tyr Lys Ser Phe Phe Ile Ile Val Gly Met Phe Leu
    1330                1335                1340                
Leu Leu Leu Cys Tyr Ala Phe Ala Gly Val Val Leu Phe Gly Thr Val
1345                1350                1355                1360
Lys Tyr Gly Glu Asn Ile Asn Arg His Ala Asn Phe Ser Ser Ala Gly
                1365                1370                1375    
Lys Ala Ile Thr Val Leu Phe Arg Ile Val Thr Gly Glu Asp Trp Asn
            1380                1385                1390        
Lys Ile Met His Asp Cys Met Val Gln Pro Pro Phe Cys Thr Pro Asp
        1395                1400                1405            
Glu Phe Thr Tyr Trp Ala Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu
    1410                1415                1420                
Met Tyr Phe Cys Ser Phe Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn
1425                1430                1435                1440
Leu Leu Val Ala Ile Ile Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr
                1445                1450                1455    
Glu Glu Asp Gln Leu Leu Ser Tyr Asn Asp Leu Arg His Phe Gln Ile
            1460                1465                1470        
Ile Trp Asn Met Val Asp Asp Lys Arg Glu Gly Val Ile Pro Thr Phe
        1475                1480                1485            
Arg Val Lys Phe Leu Leu Arg Leu Leu Arg Gly Arg Leu Glu Val Asp
    1490                1495                1500                
Leu Asp Lys Asp Lys Leu Leu Phe Lys His Met Cys Tyr Glu Met Glu
1505                1510                1515                1520
Arg Leu His Asn Gly Gly Asp Val Thr Phe His Asp Val Leu Ser Met
                1525                1530                1535    
Leu Ser Tyr Arg Ser Val Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu
            1540                1545                1550        
Leu Leu Ala Arg Glu Gln Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala
        1555                1560                1565            
Lys Gln Thr Ile Arg Met Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg
    1570                1575                1580                
Ala Lys Gln Gln Gln Ser Cys Ser Ile Ile His Ser Leu Arg Glu Ser
1585                1590                1595                1600
Gln Gln Gln Glu Leu Ser Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr
                1605                1610                1615    
Thr Gln Pro Ser Glu Asp Thr Asn Ala Asn Ser Gln Asp Asn Ser Met
            1620                1625                1630        
Gln Pro Glu Thr Ser Ser Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser
        1635                1640                1645            
Asp Arg Gly Gly Ser Arg Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln
    1650                1655                1660                
Arg Lys Phe Gly Gln Trp Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser
1665                1670                1675                1680
His Ser Val Ser Ser Val Asn Leu Arg Phe Gly Gly Arg Thr Thr Met
                1685                1690                1695    
Lys Ser Val Val Cys Lys Met Asn Pro Met Thr Asp Ala Ala Ser Cys
            1700                1705                1710        
Gly Ser Glu Val Lys Lys Trp Trp Thr Arg Gln Leu Thr Val Glu Ser
        1715                1720                1725            
Asp Glu Ser Gly Asp Asp Leu Leu Asp Ile
    1730                1735            


<210> 9333
<211> 1172
<212> PRT
<213> Homo sapiens

<400> 9333
Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val
 1               5                  10                  15      
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val
            20                  25                  30          
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu
        35                  40                  45              
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp
    50                  55                  60                  
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr
65                  70                  75                  80  
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn
                85                  90                  95      
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val
            100                 105                 110         
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln
        115                 120                 125             
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser
    130                 135                 140                 
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile
145                 150                 155                 160 
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu
                165                 170                 175     
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg
            180                 185                 190         
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg
        195                 200                 205             
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu
    210                 215                 220                 
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu
225                 230                 235                 240 
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln
                245                 250                 255     
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala
            260                 265                 270         
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro
        275                 280                 285             
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg
    290                 295                 300                 
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr
305                 310                 315                 320 
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr
                325                 330                 335     
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val
            340                 345                 350         
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg
        355                 360                 365             
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile
    370                 375                 380                 
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe
385                 390                 395                 400 
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile
                405                 410                 415     
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn
            420                 425                 430         
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu
        435                 440                 445             
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val
    450                 455                 460                 
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu
465                 470                 475                 480 
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe
                485                 490                 495     
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu
            500                 505                 510         
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu
        515                 520                 525             
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro
    530                 535                 540                 
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn
545                 550                 555                 560 
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu
                565                 570                 575     
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr
            580                 585                 590         
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe
        595                 600                 605             
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu
    610                 615                 620                 
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys
625                 630                 635                 640 
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe
                645                 650                 655     
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr
            660                 665                 670         
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp
        675                 680                 685             
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val
    690                 695                 700                 
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met
705                 710                 715                 720 
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu
                725                 730                 735     
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu
            740                 745                 750         
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys
        755                 760                 765             
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala
    770                 775                 780                 
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile
785                 790                 795                 800 
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu
                805                 810                 815     
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys
            820                 825                 830         
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala
        835                 840                 845             
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe
    850                 855                 860                 
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile
865                 870                 875                 880 
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu
                885                 890                 895     
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp
            900                 905                 910         
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu
        915                 920                 925             
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu
    930                 935                 940                 
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly
945                 950                 955                 960 
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val
                965                 970                 975     
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln
            980                 985                 990         
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met
        995                 1000                1005            
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser
    1010                1015                1020                
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser
1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp
                1045                1050                1055    
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser
            1060                1065                1070        
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg
        1075                1080                1085            
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp
    1090                1095                1100                
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val
1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys
                1125                1130                1135    
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys
            1140                1145                1150        
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp
        1155                1160                1165            
Leu Leu Asp Ile
    1170        


<210> 9334
<211> 730
<212> PRT
<213> Homo sapiens

<400> 9334
Met Pro Lys Asn Ser Lys Val Val Lys Arg Glu Leu Asp Asp Asp Val
 1               5                  10                  15      
Thr Glu Ser Val Lys Asp Leu Leu Ser Asn Glu Asp Ala Ala Asp Asp
            20                  25                  30          
Ala Phe Lys Thr Ser Glu Leu Ile Val Asp Gly Gln Glu Glu Lys Asp
        35                  40                  45              
Thr Asp Val Glu Glu Gly Ser Glu Val Glu Asp Glu Arg Pro Ala Trp
    50                  55                  60                  
Asn Ser Lys Leu Gln Tyr Ile Leu Ala Gln Val Gly Phe Ser Val Gly
65                  70                  75                  80  
Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Lys Asn Gly Gly
                85                  90                  95      
Gly Ala Tyr Leu Leu Pro Tyr Leu Ile Leu Leu Met Val Ile Gly Ile
            100                 105                 110         
Pro Leu Phe Phe Leu Glu Leu Ser Val Gly Gln Arg Ile Arg Arg Gly
        115                 120                 125             
Ser Ile Gly Val Trp Asn Tyr Ile Ser Pro Lys Leu Gly Gly Ile Gly
    130                 135                 140                 
Phe Ala Ser Cys Val Val Cys Tyr Phe Val Ala Leu Tyr Tyr Asn Val
145                 150                 155                 160 
Ile Ile Gly Trp Ser Leu Phe Tyr Phe Ser Gln Ser Phe Gln Gln Pro
                165                 170                 175     
Leu Pro Trp Asp Gln Cys Pro Leu Val Lys Asn Ala Ser His Thr Phe
            180                 185                 190         
Val Glu Pro Glu Cys Glu Gln Ser Ser Ala Thr Thr Tyr Tyr Trp Tyr
        195                 200                 205             
Arg Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser Glu Ser Gly Gly Leu
    210                 215                 220                 
Asn Trp Lys Met Thr Ile Cys Leu Leu Ala Ala Trp Val Met Val Cys
225                 230                 235                 240 
Leu Ala Met Ile Lys Gly Ile Gln Ser Ser Gly Lys Ile Ile Tyr Phe
                245                 250                 255     
Ser Ser Leu Phe Pro Tyr Val Val Leu Ile Cys Phe Leu Ile Arg Ala
            260                 265                 270         
Phe Leu Leu Asn Gly Ser Ile Asp Gly Ile Arg His Met Phe Thr Pro
        275                 280                 285             
Lys Leu Glu Ile Met Leu Glu Pro Lys Val Trp Arg Glu Ala Ala Thr
    290                 295                 300                 
Gln Val Phe Phe Ala Leu Gly Leu Gly Phe Gly Gly Val Ile Ala Phe
305                 310                 315                 320 
Ser Ser Tyr Asn Lys Arg Asp Asn Asn Cys His Phe Asp Ala Val Leu
                325                 330                 335     
Val Ser Phe Ile Asn Phe Phe Thr Ser Val Leu Ala Thr Leu Val Val
            340                 345                 350         
Phe Ala Val Leu Gly Phe Lys Ala Asn Val Ile Asn Glu Lys Cys Ile
        355                 360                 365             
Thr Gln Asn Ser Glu Thr Ile Met Lys Phe Leu Lys Met Gly Asn Ile
    370                 375                 380                 
Ser Gln Asp Ile Ile Pro His His Ile Asn Leu Ser Thr Val Thr Ala
385                 390                 395                 400 
Glu Asp Tyr His Leu Val Tyr Asp Ile Ile Gln Lys Val Lys Glu Glu
                405                 410                 415     
Glu Phe Pro Ala Leu His Leu Asn Ser Cys Lys Ile Glu Glu Glu Leu
            420                 425                 430         
Asn Lys Ala Val Gln Gly Thr Gly Leu Ala Phe Ile Ala Phe Thr Glu
        435                 440                 445             
Ala Met Thr His Phe Pro Ala Ser Pro Phe Trp Ser Val Met Phe Phe
    450                 455                 460                 
Leu Met Leu Val Asn Leu Gly Leu Gly Ser Met Phe Gly Thr Ile Glu
465                 470                 475                 480 
Gly Ile Val Thr Pro Ile Val Asp Thr Phe Lys Val Arg Lys Glu Ile
                485                 490                 495     
Leu Thr Val Ile Cys Cys Leu Leu Ala Phe Cys Ile Gly Leu Ile Phe
            500                 505                 510         
Val Gln Arg Ser Gly Asn Tyr Phe Val Thr Met Phe Asp Asp Tyr Ser
        515                 520                 525             
Ala Thr Leu Pro Leu Leu Ile Val Val Ile Leu Glu Asn Ile Ala Val
    530                 535                 540                 
Cys Phe Val Tyr Gly Ile Asp Lys Phe Met Glu Asp Leu Lys Asp Met
545                 550                 555                 560 
Leu Gly Phe Ala Pro Ser Arg Tyr Tyr Tyr Tyr Met Trp Lys Tyr Ile
                565                 570                 575     
Ser Pro Leu Met Leu Leu Ser Leu Leu Ile Ala Ser Val Val Asn Met
            580                 585                 590         
Gly Leu Ser Pro Pro Gly Tyr Asn Ala Trp Ile Glu Asp Lys Ala Ser
        595                 600                 605             
Glu Glu Phe Leu Ser Tyr Pro Thr Trp Gly Leu Val Val Cys Val Ser
    610                 615                 620                 
Leu Val Val Phe Ala Ile Leu Pro Val Pro Val Val Phe Ile Val Arg
625                 630                 635                 640 
Arg Phe Asn Leu Ile Asp Asp Ser Ser Gly Asn Leu Ala Ser Val Thr
                645                 650                 655     
Tyr Lys Arg Gly Arg Val Leu Lys Glu Pro Val Asn Leu Glu Gly Asp
            660                 665                 670         
Asp Thr Ser Leu Ile His Gly Lys Ile Pro Ser Glu Met Pro Ser Pro
        675                 680                 685             
Asn Phe Gly Lys Asn Ile Tyr Arg Lys Gln Ser Gly Ser Pro Thr Leu
    690                 695                 700                 
Asp Thr Ala Pro Asn Gly Arg Tyr Gly Ile Gly Tyr Leu Met Ala Asp
705                 710                 715                 720 
Ile Met Pro Asp Met Pro Glu Ser Asp Leu
                725                 730 


<210> 9335
<211> 289
<212> PRT
<213> Homo sapiens

<400> 9335
Met Pro Lys Asn Ser Lys Val Val Lys Arg Glu Leu Asp Asp Asp Val
 1               5                  10                  15      
Thr Glu Ser Val Lys Asp Leu Leu Ser Asn Glu Asp Ala Ala Asp Asp
            20                  25                  30          
Ala Phe Lys Thr Ser Glu Leu Ile Val Asp Gly Gln Glu Glu Lys Asp
        35                  40                  45              
Thr Asp Val Glu Glu Gly Ser Glu Val Glu Asp Glu Arg Pro Ala Trp
    50                  55                  60                  
Asn Ser Lys Leu Gln Tyr Ile Leu Ala Gln Val Gly Phe Ser Val Gly
65                  70                  75                  80  
Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Lys Asn Gly Gly
                85                  90                  95      
Gly Ala Tyr Leu Leu Pro Tyr Leu Ile Leu Leu Met Val Ile Gly Ile
            100                 105                 110         
Pro Leu Phe Phe Leu Glu Leu Ser Val Gly Gln Arg Ile Arg Arg Gly
        115                 120                 125             
Ser Ile Gly Val Trp Asn Tyr Ile Ser Pro Lys Leu Gly Gly Ile Gly
    130                 135                 140                 
Phe Ala Ser Cys Val Val Cys Tyr Phe Val Ala Leu Tyr Tyr Asn Val
145                 150                 155                 160 
Ile Ile Gly Trp Ser Leu Phe Tyr Phe Ser Gln Ser Phe Gln Gln Pro
                165                 170                 175     
Leu Pro Trp Asp Gln Cys Pro Leu Val Lys Asn Ala Ser His Thr Phe
            180                 185                 190         
Val Glu Pro Glu Cys Glu Gln Ser Ser Ala Thr Thr Tyr Tyr Trp Tyr
        195                 200                 205             
Arg Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser Glu Ser Gly Gly Leu
    210                 215                 220                 
Asn Trp Lys Met Thr Ile Cys Leu Leu Ala Ala Trp Val Met Val Cys
225                 230                 235                 240 
Leu Ala Met Ile Lys Gly Ile Gln Ser Ser Gly Lys Val Ser Met Leu
                245                 250                 255     
Glu Pro Phe Leu Ile Leu Leu Ile Thr Ile Ser Gly Phe Ile Pro Leu
            260                 265                 270         
Ser Asn Ser Val Thr Asp Phe Cys Gly Gln Ile Thr His Asn Thr Ser
        275                 280                 285             
Phe
    


<210> 9336
<211> 604
<212> PRT
<213> Homo sapiens

<400> 9336
Met Gly Glu Val Val Asp Lys Gly Trp Ala Ser Gly Gly Arg Arg Val
 1               5                  10                  15      
Gln Ala Val Leu Ala Val Pro Thr Gly Cys Ala Ala Gly Ser Glu Leu
            20                  25                  30          
Ala Phe Val Gln Glu Leu Gly Asp Thr Val Ala Val Trp Glu His Pro
        35                  40                  45              
Leu Val Leu Pro Cys Gln Val Glu Gly Glu Pro Pro Val Ser Ile Ser
    50                  55                  60                  
Trp Gln Arg Asp Arg Leu Ala Leu Ala Asn Glu Ser Gly Val Thr Leu
65                  70                  75                  80  
Met Pro Asp Gly Ser Leu His Leu Ala Ala Leu Pro Ser Arg Arg Ser
                85                  90                  95      
Leu Pro Ser Arg Ala His Glu Tyr His Cys Val Ala Gln Asn Arg Tyr
            100                 105                 110         
Gly Arg Leu Val Ser Arg Gln Ala Arg Val Gln Leu Ala Ser Leu Ser
        115                 120                 125             
Arg Phe His Gln His Pro Glu Ser Ile Glu Val Glu Arg Gly Gly Val
    130                 135                 140                 
Ala Arg Phe Gln Cys Leu Ile Gln Gly Val Pro Glu Pro Ser Ile Ser
145                 150                 155                 160 
Trp Glu His Asn Gly Thr Ala Leu Asn Thr Ala Asn His Arg Val Thr
                165                 170                 175     
Leu Leu Pro Ser Gly Ile Leu His Ile Thr Ser Val Ser Gln Thr Asp
            180                 185                 190         
Met Gly Thr Tyr Arg Cys Val Ala Trp Asn Val Ala Ser Thr Arg His
        195                 200                 205             
Ser Gln Asp Ala Gln Leu Thr Leu Ser Val Gly Pro Leu Arg Leu Leu
    210                 215                 220                 
Gln Glu Pro Glu Ile Leu Ser Gly Pro Gln Asn Leu Thr Leu Thr Val
225                 230                 235                 240 
His Gln Thr Ala Val Leu Glu Cys Ile Ala Thr Ser His Pro Trp Pro
                245                 250                 255     
Leu Val Ser Trp Ser Arg Leu Asp Gly Arg Ser Ile Gly Val Glu Gly
            260                 265                 270         
Ile Gln Val Leu Asp Ile Leu Asp Thr Gly Asn Leu Met Ile Ser Asp
        275                 280                 285             
Val Ser Val Gln His Ser Gly Val Tyr Val Cys Ala Ala Asn Arg Pro
    290                 295                 300                 
Gly Thr His Val Arg Arg Thr Ala Gln Gly Val Leu Leu Val Gln Gly
305                 310                 315                 320 
Glu Pro Gln Gly Pro Asn Trp Leu Pro Glu Phe Val Gln Trp Pro Gln
                325                 330                 335     
Ser Leu Ser Lys Pro Pro Gly Ser Ser Ala Ile Phe Thr Cys Val Ala
            340                 345                 350         
Gln Gly Val Pro Glu Ser Arg Leu Val Trp Leu Lys Asn Gly Lys Val
        355                 360                 365             
Leu Ser Pro Gly Asn Asn Ile Arg Leu Thr His Asn Asn Ser Thr Leu
    370                 375                 380                 
Met Leu Ala Gly Val Ser Val Glu Asp Glu Ala Ile Tyr Gln Cys Val
385                 390                 395                 400 
Ala Glu Asn Ser Thr Gly Ser Asn Gln Ala Ser Ala Arg Leu Val Val
                405                 410                 415     
Thr Gly Gly Pro Glu Pro Pro Arg Pro Gln Gly Pro Ala Cys His Gly
            420                 425                 430         
Ser Leu Tyr Phe Cys His Ser Ser Val Leu Gly Ala Thr Pro Pro Ser
        435                 440                 445             
Ser Arg Asp Ile Ile Gly Tyr Val Leu His Leu Arg Pro Val Gly Glu
    450                 455                 460                 
Pro Ser Gly Pro Glu Leu Gln Glu Ala Ile Ser Lys Gly Thr Ser Glu
465                 470                 475                 480 
His Val Phe Ser Asn Leu Glu Pro Ala Thr Ala Tyr Thr Ile His Leu
                485                 490                 495     
Arg Ala Tyr Ser Ala Glu Gly Ala Ser Gln Asp Ser Ala Pro Ile Phe
            500                 505                 510         
Ala Ser Thr Met Gly Ser Lys Pro Ala Ala Leu Tyr Asp Ile Lys Leu
        515                 520                 525             
Gln Ala Phe Asn Gly Asn Gly Asp Gly Asn Ser Ser Ala Arg Cys Val
    530                 535                 540                 
Ser Leu Cys Asp Val Pro Leu Ala Thr Pro Asp Gly Thr Val Ser Thr
545                 550                 555                 560 
Glu Ser Lys Thr Gly Cys Ser Cys Ser Gln Gly Glu Ser Ser Pro Leu
                565                 570                 575     
Pro Gly Val Val Val Gly Ile His Val Gly Leu Ala Ala Leu Ile Ile
            580                 585                 590         
Cys Leu Leu Cys Leu Phe Leu Gly Trp Arg His Ser
        595                 600                 


<210> 9337
<211> 891
<212> PRT
<213> Homo sapiens

<400> 9337
Met Ser Gln Val Gly Gly Arg Gly Asp Arg Cys Thr Gln Glu Val Gln
 1               5                  10                  15      
Gly Leu Val His Gly Ala Gly Asp Leu Ser Ala Ser Leu Ala Glu Asn
            20                  25                  30          
Ser Pro Thr Met Ser Gln Asn Gly Tyr Phe Glu Asp Ser Ser Tyr Tyr
        35                  40                  45              
Lys Cys Asp Thr Asp Asp Thr Phe Glu Ala Arg Glu Glu Ile Leu Gly
    50                  55                  60                  
Asp Glu Ala Phe Asp Thr Ala Asn Ser Ser Ile Val Ser Gly Glu Ser
65                  70                  75                  80  
Ile Arg Phe Phe Val Asn Val Asn Leu Glu Met Gln Ala Thr Asn Thr
                85                  90                  95      
Glu Asn Glu Ala Thr Ser Gly Gly Cys Val Leu Leu His Thr Ser Arg
            100                 105                 110         
Lys Tyr Leu Lys Leu Lys Asn Phe Lys Glu Glu Ile Arg Ala His Arg
        115                 120                 125             
Asp Leu Asp Gly Phe Leu Ala Gln Ala Ser Ile Val Leu Asn Glu Thr
    130                 135                 140                 
Ala Thr Ser Leu Asp Asn Val Leu Arg Thr Met Leu Arg Arg Phe Ala
145                 150                 155                 160 
Arg Asp Pro Asp Asn Asn Glu Pro Asn Cys Asn Leu Asp Leu Leu Met
                165                 170                 175     
Ala Met Leu Phe Thr Asp Ala Gly Ala Pro Met Arg Gly Lys Val His
            180                 185                 190         
Leu Leu Ser Asp Thr Ile Gln Gly Val Thr Ala Thr Val Thr Gly Val
        195                 200                 205             
Arg Tyr Gln Gln Ser Trp Leu Cys Ile Ile Cys Thr Met Lys Ala Leu
    210                 215                 220                 
Gln Lys Arg His Val Cys Ile Ser Arg Leu Val Arg Pro Gln Asn Trp
225                 230                 235                 240 
Gly Glu Asn Ser Cys Glu Val Arg Phe Val Ile Leu Val Leu Ala Pro
                245                 250                 255     
Pro Lys Met Lys Ser Thr Lys Thr Ala Met Glu Val Ala Arg Thr Phe
            260                 265                 270         
Ala Thr Met Phe Ser Asp Ile Ala Phe Arg Gln Lys Leu Leu Glu Thr
        275                 280                 285             
Arg Thr Glu Glu Glu Phe Lys Glu Ala Leu Val His Gln Arg Gln Leu
    290                 295                 300                 
Leu Thr Met Val Ser His Gly Pro Val Ala Pro Arg Thr Lys Glu Arg
305                 310                 315                 320 
Ser Thr Val Ser Leu Pro Ala His Arg His Pro Glu Pro Pro Lys Cys
                325                 330                 335     
Lys Asp Phe Val Pro Phe Gly Lys Gly Ile Arg Glu Asp Ile Ala Arg
            340                 345                 350         
Arg Phe Pro Leu Tyr Pro Leu Asp Phe Thr Asp Gly Ile Ile Gly Lys
        355                 360                 365             
Asn Lys Ala Val Gly Lys Tyr Ile Thr Thr Thr Leu Phe Leu Tyr Phe
    370                 375                 380                 
Ala Cys Leu Leu Pro Thr Ile Ala Phe Gly Ser Leu Asn Asp Glu Asn
385                 390                 395                 400 
Thr Asp Gly Ala Ile Asp Val Gln Lys Thr Ile Ala Gly Gln Ser Ile
                405                 410                 415     
Gly Gly Leu Leu Tyr Ala Leu Phe Ser Gly Gln Pro Leu Val Ile Leu
            420                 425                 430         
Leu Thr Thr Ala Pro Leu Ala Leu Tyr Ile Gln Val Ile Arg Val Ile
        435                 440                 445             
Cys Asp Asp Tyr Asp Leu Asp Phe Asn Ser Phe Tyr Ala Trp Thr Gly
    450                 455                 460                 
Leu Trp Asn Ser Phe Phe Leu Ala Leu Tyr Ala Phe Phe Asn Leu Ser
465                 470                 475                 480 
Leu Val Met Ser Leu Phe Lys Arg Ser Thr Glu Glu Ile Ile Ala Leu
                485                 490                 495     
Phe Ile Ser Ile Thr Phe Val Leu Asp Ala Val Lys Gly Thr Val Lys
            500                 505                 510         
Ile Phe Trp Lys Tyr Tyr Tyr Gly His Tyr Leu Asp Asp Tyr His Thr
        515                 520                 525             
Lys Arg Thr Ser Ser Leu Val Ser Leu Ser Gly Leu Gly Ala Ser Leu
    530                 535                 540                 
Asn Ala Ser Leu His Thr Ala Leu Asn Ala Ser Phe Leu Ala Ser Pro
545                 550                 555                 560 
Thr Glu Leu Pro Ser Ala Thr His Ser Gly Gln Ala Thr Ala Val Leu
                565                 570                 575     
Ser Leu Leu Ile Met Leu Gly Thr Leu Trp Leu Gly Tyr Thr Leu Tyr
            580                 585                 590         
Gln Phe Lys Lys Ser Pro Tyr Leu His Pro Cys Val Arg Glu Ile Leu
        595                 600                 605             
Ser Asp Cys Ala Leu Pro Ile Ala Val Leu Ala Phe Ser Leu Ile Ser
    610                 615                 620                 
Ser His Gly Phe Arg Glu Ile Glu Met Ser Lys Phe Arg Tyr Asn Pro
625                 630                 635                 640 
Ser Glu Ser Pro Phe Ala Met Ala Gln Ile Gln Ser Leu Ser Leu Arg
                645                 650                 655     
Ala Val Ser Gly Ala Met Gly Leu Gly Phe Leu Leu Ser Met Leu Phe
            660                 665                 670         
Phe Ile Glu Gln Asn Leu Val Ala Ala Leu Val Asn Ala Pro Glu Asn
        675                 680                 685             
Arg Leu Val Lys Gly Thr Ala Tyr His Trp Asp Leu Leu Leu Leu Ala
    690                 695                 700                 
Ile Ile Asn Thr Gly Leu Ser Leu Phe Gly Leu Pro Trp Ile His Ala
705                 710                 715                 720 
Ala Tyr Pro His Ser Pro Leu His Val Arg Ala Leu Ala Leu Val Glu
                725                 730                 735     
Glu Arg Val Glu Asn Gly His Ile Tyr Asp Thr Ile Val Asn Val Lys
            740                 745                 750         
Glu Thr Arg Leu Thr Ser Leu Gly Ala Ser Val Leu Val Gly Leu Ser
        755                 760                 765             
Leu Leu Leu Leu Pro Val Pro Leu Gln Trp Ile Pro Lys Pro Val Leu
    770                 775                 780                 
Tyr Gly Leu Phe Leu Tyr Ile Ala Leu Thr Ser Leu Asp Gly Asn Gln
785                 790                 795                 800 
Leu Val Gln Arg Val Ala Leu Leu Leu Lys Glu Gln Thr Ala Tyr Pro
                805                 810                 815     
Pro Thr His Tyr Ile Arg Arg Val Pro Gln Arg Lys Ile His Tyr Phe
            820                 825                 830         
Thr Gly Leu Gln Val Leu Gln Leu Leu Leu Leu Cys Ala Phe Gly Met
        835                 840                 845             
Ser Ser Leu Pro Tyr Met Lys Met Ile Phe Pro Leu Ile Met Ile Ala
    850                 855                 860                 
Met Ile Pro Ile Arg Tyr Ile Leu Leu Pro Arg Ile Ile Glu Ala Lys
865                 870                 875                 880 
Tyr Leu Asp Val Met Asp Ala Glu His Arg Pro
                885                 890     


<210> 9338
<211> 911
<212> PRT
<213> Homo sapiens

<400> 9338
Met Ala Glu Lys Ala Pro Pro Gly Leu Asn Arg Lys Thr Ser Arg Ser
 1               5                  10                  15      
Thr Leu Ser Leu Pro Pro Glu Pro Val Asp Ile Ile Arg Ser Lys Thr
            20                  25                  30          
Cys Ser Arg Arg Val Lys Ile Asn Val Gly Gly Leu Asn His Glu Val
        35                  40                  45              
Leu Trp Arg Thr Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu
    50                  55                  60                  
Arg Asp Cys Asn Thr His Glu Ser Leu Leu Glu Val Cys Asp Asp Tyr
65                  70                  75                  80  
Asn Leu Asn Glu Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe
                85                  90                  95      
Thr Ser Ile Leu Asn Phe Tyr Arg Thr Gly Lys Leu His Met Met Glu
            100                 105                 110         
Glu Met Cys Ala Leu Ser Phe Gly Gln Glu Leu Asp Tyr Trp Gly Ile
        115                 120                 125             
Asp Glu Ile Tyr Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys
    130                 135                 140                 
Lys Glu Gln Met Asn Glu Glu Leu Arg Arg Glu Ala Glu Thr Met Arg
145                 150                 155                 160 
Glu Arg Glu Gly Glu Glu Phe Asp Asn Thr Cys Cys Pro Asp Lys Arg
                165                 170                 175     
Lys Lys Leu Trp Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala
            180                 185                 190         
Lys Ile Leu Ala Ile Val Ser Ile Leu Phe Ile Val Leu Ser Thr Ile
        195                 200                 205             
Ala Leu Ser Leu Asn Thr Leu Pro Glu Leu Gln Glu Thr Asp Glu Phe
    210                 215                 220                 
Gly Gln Leu Asn Asp Asn Arg Gln Leu Ala His Val Glu Ala Val Cys
225                 230                 235                 240 
Ile Ala Trp Phe Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro
                245                 250                 255     
Asn Lys Trp Lys Phe Phe Lys Gly Pro Leu Asn Val Ile Asp Leu Leu
            260                 265                 270         
Ala Ile Leu Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys
        275                 280                 285             
Ser Val Leu Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg
    290                 295                 300                 
Ile Met Arg Ile Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly
305                 310                 315                 320 
Leu Gln Ser Leu Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly
                325                 330                 335     
Leu Leu Ile Leu Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu
            340                 345                 350         
Val Phe Phe Ala Glu Lys Asp Glu Asp Ala Thr Lys Phe Thr Ser Ile
        355                 360                 365             
Pro Ala Ser Phe Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr
    370                 375                 380                 
Gly Asp Ile Tyr Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu
385                 390                 395                 400 
Cys Cys Ile Ala Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile
                405                 410                 415     
Val Asn Asn Phe Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys
            420                 425                 430         
Ala Ile Lys Arg Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser
        435                 440                 445             
Ile Val Ser Met Asn Leu Lys Asp Ala Phe Ala Arg Ser Met Glu Leu
    450                 455                 460                 
Ile Asp Val Ala Val Glu Lys Ala Gly Glu Ser Ala Asn Thr Lys Asp
465                 470                 475                 480 
Ser Ala Asp Asp Asn His Leu Ser Pro Ser Arg Trp Lys Trp Ala Arg
                485                 490                 495     
Lys Ala Leu Ser Glu Thr Ser Ser Asn Lys Ser Phe Glu Asn Lys Tyr
            500                 505                 510         
Gln Glu Val Ser Gln Lys Asp Ser His Glu Gln Leu Asn Asn Thr Ser
        515                 520                 525             
Ser Ser Ser Pro Gln His Leu Ser Ala Gln Lys Leu Glu Met Leu Tyr
    530                 535                 540                 
Asn Glu Ile Thr Lys Thr Gln Pro His Ser His Pro Asn Pro Asp Cys
545                 550                 555                 560 
Gln Glu Lys Pro Glu Arg Pro Ser Ala Tyr Glu Glu Glu Ile Glu Met
                565                 570                 575     
Glu Glu Val Val Cys Pro Gln Glu Gln Leu Ala Val Ala Gln Thr Glu
            580                 585                 590         
Val Ile Val Asp Met Lys Ser Thr Ser Ser Ile Asp Ser Phe Thr Ser
        595                 600                 605             
Cys Ala Thr Asp Phe Thr Glu Thr Glu Arg Ser Pro Leu Pro Pro Pro
    610                 615                 620                 
Ser Ala Ser His Leu Gln Met Lys Phe Pro Thr Asp Leu Pro Gly Thr
625                 630                 635                 640 
Glu Glu His Gln Arg Ala Arg Gly Pro Pro Phe Leu Thr Leu Ser Arg
                645                 650                 655     
Glu Lys Gly Pro Ala Ala Arg Asp Gly Thr Leu Glu Tyr Ala Pro Val
            660                 665                 670         
Asp Ile Thr Val Asn Leu Asp Ala Ser Gly Ser Gln Cys Gly Leu His
        675                 680                 685             
Ser Pro Leu Gln Ser Asp Asn Ala Thr Asp Ser Pro Lys Ser Ser Leu
    690                 695                 700                 
Lys Gly Ser Asn Pro Leu Lys Ser Arg Ser Leu Lys Val Asn Phe Lys
705                 710                 715                 720 
Glu Asn Arg Gly Ser Ala Pro Gln Thr Pro Pro Ser Thr Ala Arg Pro
                725                 730                 735     
Leu Pro Val Thr Thr Ala Asp Phe Ser Leu Thr Thr Pro Gln His Ile
            740                 745                 750         
Ser Thr Ile Leu Leu Glu Glu Thr Pro Ser Gln Gly Asp Arg Pro Leu
        755                 760                 765             
Leu Gly Thr Glu Val Ser Ala Pro Cys Gln Gly Pro Ser Lys Gly Leu
    770                 775                 780                 
Ser Pro Arg Phe Pro Lys Gln Lys Leu Phe Pro Phe Ser Ser Arg Glu
785                 790                 795                 800 
Arg Arg Ser Phe Thr Glu Ile Asp Thr Gly Asp Asp Glu Asp Phe Leu
                805                 810                 815     
Glu Leu Pro Gly Ala Arg Glu Glu Lys Gln Val Asp Ser Ser Pro Asn
            820                 825                 830         
Cys Phe Ala Asp Lys Pro Ser Asp Gly Arg Asp Pro Leu Arg Glu Glu
        835                 840                 845             
Gly Ser Val Gly Ser Ser Ser Pro Gln Asp Thr Gly His Asn Cys Arg
    850                 855                 860                 
Gln Asp Ile Tyr His Ala Val Ser Glu Val Lys Lys Asp Ser Ser Gln
865                 870                 875                 880 
Glu Gly Cys Lys Met Glu Asn His Leu Phe Ala Pro Glu Ile His Ser
                885                 890                 895     
Asn Pro Gly Asp Thr Gly Tyr Cys Pro Thr Arg Glu Thr Ser Met
            900                 905                 910     


<210> 9339
<211> 936
<212> PRT
<213> Homo sapiens

<400> 9339
Met Leu Gly Pro Ala Val Leu Gly Leu Ser Leu Trp Ala Leu Leu His
 1               5                  10                  15      
Pro Gly Thr Gly Ala Pro Leu Cys Leu Ser Gln Gln Leu Arg Met Lys
            20                  25                  30          
Gly Asp Tyr Val Leu Gly Gly Leu Phe Pro Leu Gly Glu Ala Glu Glu
        35                  40                  45              
Ala Gly Leu Arg Ser Arg Thr Arg Pro Ser Ser Pro Val Cys Thr Arg
    50                  55                  60                  
Phe Ser Ser Asn Gly Leu Leu Trp Ala Leu Ala Met Lys Met Ala Val
65                  70                  75                  80  
Glu Glu Ile Asn Asn Lys Ser Asp Leu Leu Pro Gly Leu Arg Leu Gly
                85                  90                  95      
Tyr Asp Leu Phe Asp Thr Cys Ser Glu Pro Val Val Ala Met Lys Pro
            100                 105                 110         
Ser Leu Met Phe Leu Ala Lys Ala Gly Ser Arg Asp Ile Ala Ala Tyr
        115                 120                 125             
Cys Asn Tyr Thr Gln Tyr Gln Pro Arg Val Leu Ala Val Ile Gly Pro
    130                 135                 140                 
His Ser Ser Glu Leu Ala Met Val Thr Gly Lys Phe Phe Ser Phe Phe
145                 150                 155                 160 
Leu Met Pro Gln Val Ser Tyr Gly Ala Ser Met Glu Leu Leu Ser Ala
                165                 170                 175     
Arg Glu Thr Phe Pro Ser Phe Phe Arg Thr Val Pro Ser Asp Arg Val
            180                 185                 190         
Gln Leu Thr Ala Ala Ala Glu Leu Leu Gln Glu Phe Gly Trp Asn Trp
        195                 200                 205             
Val Ala Ala Leu Gly Ser Asp Asp Glu Tyr Gly Arg Gln Gly Leu Ser
    210                 215                 220                 
Ile Phe Ser Ala Leu Ala Ala Ala Arg Gly Ile Cys Ile Ala His Glu
225                 230                 235                 240 
Gly Leu Val Pro Leu Pro Arg Ala Asp Asp Ser Arg Leu Gly Lys Val
                245                 250                 255     
Gln Asp Val Leu His Gln Val Asn Gln Ser Ser Val Gln Val Val Leu
            260                 265                 270         
Leu Phe Ala Ser Val His Ala Ala His Ala Leu Phe Asn Tyr Ser Ile
        275                 280                 285             
Ser Ser Arg Leu Ser Pro Lys Val Trp Val Ala Ser Glu Ala Trp Leu
    290                 295                 300                 
Thr Ser Asp Leu Val Met Gly Leu Pro Gly Met Ala Gln Met Gly Thr
305                 310                 315                 320 
Val Leu Gly Phe Leu Gln Arg Gly Ala Gln Leu His Glu Phe Pro Gln
                325                 330                 335     
Tyr Val Lys Thr His Leu Ala Leu Ala Thr Asp Pro Ala Phe Cys Ser
            340                 345                 350         
Ala Leu Gly Glu Arg Glu Gln Gly Leu Glu Glu Asp Val Val Gly Gln
        355                 360                 365             
Arg Cys Pro Gln Cys Asp Cys Ile Thr Leu Gln Asn Val Ser Ala Gly
    370                 375                 380                 
Leu Asn His His Gln Thr Phe Ser Val Tyr Ala Ala Val Tyr Ser Val
385                 390                 395                 400 
Ala Gln Ala Leu His Asn Thr Leu Gln Cys Asn Ala Ser Gly Cys Pro
                405                 410                 415     
Ala Gln Asp Pro Val Lys Pro Trp Gln Leu Leu Glu Asn Met Tyr Asn
            420                 425                 430         
Leu Thr Phe His Val Gly Gly Leu Pro Leu Arg Phe Asp Ser Ser Gly
        435                 440                 445             
Asn Val Asp Met Glu Tyr Asp Leu Lys Leu Trp Val Trp Gln Gly Ser
    450                 455                 460                 
Val Pro Arg Leu His Asp Val Gly Arg Phe Asn Gly Ser Leu Arg Thr
465                 470                 475                 480 
Glu Arg Leu Lys Ile Arg Trp His Thr Ser Asp Asn Gln Lys Pro Val
                485                 490                 495     
Ser Arg Cys Ser Arg Gln Cys Gln Glu Gly Gln Val Arg Arg Val Lys
            500                 505                 510         
Gly Phe His Ser Cys Cys Tyr Asp Cys Val Asp Cys Glu Ala Gly Ser
        515                 520                 525             
Tyr Arg Gln Asn Pro Asp Asp Ile Ala Cys Thr Phe Cys Gly Gln Asp
    530                 535                 540                 
Glu Trp Ser Pro Glu Arg Ser Thr Arg Cys Phe Arg Arg Arg Ser Arg
545                 550                 555                 560 
Phe Leu Ala Trp Gly Glu Pro Ala Val Leu Leu Leu Leu Leu Leu Leu
                565                 570                 575     
Ser Leu Ala Leu Gly Leu Val Leu Ala Ala Leu Gly Leu Phe Val His
            580                 585                 590         
His Arg Asp Ser Pro Leu Val Gln Ala Ser Gly Gly Pro Leu Ala Cys
        595                 600                 605             
Phe Gly Leu Val Cys Leu Gly Leu Val Cys Leu Ser Val Leu Leu Phe
    610                 615                 620                 
Pro Gly Gln Pro Ser Pro Ala Arg Cys Leu Ala Gln Gln Pro Leu Ser
625                 630                 635                 640 
His Leu Pro Leu Thr Gly Cys Leu Ser Thr Leu Phe Leu Gln Ala Ala
                645                 650                 655     
Glu Ile Phe Val Glu Ser Glu Leu Pro Leu Ser Trp Ala Asp Arg Leu
            660                 665                 670         
Ser Gly Cys Leu Arg Gly Pro Trp Ala Trp Leu Val Val Leu Leu Ala
        675                 680                 685             
Met Leu Val Glu Val Ala Leu Cys Thr Trp Tyr Leu Val Ala Phe Pro
    690                 695                 700                 
Pro Glu Val Val Thr Asp Trp His Met Leu Pro Thr Glu Ala Leu Val
705                 710                 715                 720 
His Cys Arg Thr Arg Ser Trp Val Ser Phe Gly Leu Ala His Ala Thr
                725                 730                 735     
Asn Ala Thr Leu Ala Phe Leu Cys Phe Leu Gly Thr Phe Leu Val Arg
            740                 745                 750         
Ser Gln Pro Gly Cys Tyr Asn Arg Ala Arg Gly Leu Thr Phe Ala Met
        755                 760                 765             
Leu Ala Tyr Phe Ile Thr Trp Val Ser Phe Val Pro Leu Leu Ala Asn
    770                 775                 780                 
Val Gln Val Val Leu Arg Pro Ala Val Gln Met Gly Ala Leu Leu Leu
785                 790                 795                 800 
Cys Val Leu Gly Ile Leu Ala Ala Phe His Leu Pro Arg Cys Tyr Leu
                805                 810                 815     
Leu Met Arg Gln Pro Gly Leu Asn Thr Pro Glu Phe Phe Leu Gly Gly
            820                 825                 830         
Gly Pro Gly Asp Ala Gln Gly Gln Asn Asp Gly Asn Thr Gly Asn Gln
        835                 840                 845             
Gly Lys His Glu Ala Pro Ile Leu His Pro Ala Arg His His Ser Ser
    850                 855                 860                 
Gly Arg Pro Gly Gly Gly Thr Gln Ala Tyr Ala Gln Gly Arg Ala Arg
865                 870                 875                 880 
Arg Gly Arg Gly Gly Thr Gln Leu Pro Thr Leu Pro Phe Ala Gln Trp
                885                 890                 895     
Val Asp Ser Ile Met Thr Val Thr Ser Thr Arg Asp Arg Ala Gln Asp
            900                 905                 910         
Leu Thr Pro Ala Arg Arg Gln Ala His Thr Gly Ser Pro Val Arg Val
        915                 920                 925             
Pro Gly Ser Ala Pro Ser Arg Ala
    930                 935     


<210> 9340
<211> 471
<212> PRT
<213> Homo sapiens

<400> 9340
Met Arg Ser Cys Leu Trp Arg Cys Arg His Leu Ser Gln Gly Val Gln
 1               5                  10                  15      
Trp Ser Leu Leu Leu Ala Val Leu Val Phe Phe Leu Phe Ala Leu Pro
            20                  25                  30          
Ser Phe Ile Lys Glu Pro Gln Thr Lys Pro Ser Arg His Gln Arg Thr
        35                  40                  45              
Glu Asn Ile Lys Glu Arg Ser Leu Gln Ser Leu Ala Lys Pro Lys Ser
    50                  55                  60                  
Gln Ala Pro Thr Arg Ala Arg Arg Thr Thr Ile Tyr Ala Glu Pro Val
65                  70                  75                  80  
Pro Glu Asn Asn Ala Leu Asn Thr Gln Thr Gln Pro Lys Ala His Thr
                85                  90                  95      
Thr Gly Asp Arg Gly Lys Glu Ala Asn Gln Ala Pro Pro Glu Glu Gln
            100                 105                 110         
Asp Lys Val Pro His Thr Ala Gln Arg Ala Ala Trp Lys Ser Pro Glu
        115                 120                 125             
Lys Glu Lys Thr Met Val Asn Thr Leu Ser Pro Arg Gly Gln Asp Ala
    130                 135                 140                 
Gly Met Ala Ser Gly Arg Thr Glu Ala Gln Ser Trp Lys Ser Gln Asp
145                 150                 155                 160 
Thr Lys Thr Thr Lys Gly Asn Gly Gly Gln Thr Arg Lys Leu Thr Ala
                165                 170                 175     
Ser Arg Thr Val Ser Glu Lys His Gln Gly Lys Ala Ala Thr Thr Ala
            180                 185                 190         
Lys Thr Leu Ile Pro Lys Ser Gln His Arg Met Leu Ala Pro Thr Gly
        195                 200                 205             
Ala Val Ser Thr Arg Thr Arg Gln Lys Gly Val Thr Thr Ala Val Ile
    210                 215                 220                 
Pro Pro Lys Glu Lys Lys Pro Gln Ala Thr Pro Pro Pro Ala Pro Phe
225                 230                 235                 240 
Gln Ser Pro Thr Thr Gln Arg Asn Gln Arg Leu Lys Ala Ala Asn Phe
                245                 250                 255     
Lys Ser Glu Pro Arg Trp Asp Phe Glu Glu Lys Tyr Ser Phe Glu Ile
            260                 265                 270         
Gly Gly Leu Gln Thr Thr Cys Pro Asp Ser Val Lys Ile Lys Ala Ser
        275                 280                 285             
Lys Ser Leu Trp Leu Gln Lys Leu Phe Leu Pro Asn Leu Thr Leu Phe
    290                 295                 300                 
Leu Asp Ser Arg His Phe Asn Gln Ser Glu Trp Asp Arg Leu Glu His
305                 310                 315                 320 
Phe Ala Pro Pro Phe Gly Phe Met Glu Leu Asn Tyr Ser Leu Val Gln
                325                 330                 335     
Lys Val Val Thr Arg Phe Pro Pro Val Pro Gln Gln Gln Leu Leu Leu
            340                 345                 350         
Ala Ser Leu Pro Ala Gly Ser Leu Arg Cys Ile Thr Cys Ala Val Val
        355                 360                 365             
Gly Asn Gly Gly Ile Leu Asn Asn Ser His Ile Gly Gln Glu Ile Asp
    370                 375                 380                 
Ser His Asp Tyr Val Phe Arg Leu Ser Gly Ala Leu Ile Lys Gly Tyr
385                 390                 395                 400 
Glu Gln Asp Val Gly Thr Arg Thr Ser Phe Tyr Gly Phe Thr Ala Phe
                405                 410                 415     
Ser Leu Thr Gln Ser Leu Leu Ile Leu Gly Asn Arg Gly Phe Lys Asn
            420                 425                 430         
Val Pro Leu Gly Lys Ala Gln Thr Pro Gly Ser Phe Ser Gly Ser Pro
        435                 440                 445             
Ala His Gly Gln Val Pro Val Ala Ala Pro Arg Leu Ser Pro Ile His
    450                 455                 460                 
Glu Glu Gln Val Ser Glu Val
465                 470     


<210> 9341
<211> 2638
<212> PRT
<213> Homo sapiens

<400> 9341
Met Gly Ile Lys Ser Gly Phe Thr Phe Trp Asn Leu Val Phe Leu Leu
 1               5                  10                  15      
Thr Val Ser Cys Val Lys Gly Phe Ile Tyr Thr Cys Gly Gly Thr Leu
            20                  25                  30          
Lys Gly Leu Asn Gly Thr Ile Glu Ser Pro Gly Phe Pro Tyr Gly Tyr
        35                  40                  45              
Pro Asn Gly Ala Asn Cys Thr Trp Val Ile Ile Ala Glu Glu Arg Asn
    50                  55                  60                  
Arg Ile Gln Ile Val Phe Gln Ser Phe Ala Leu Glu Glu Glu Tyr Asp
65                  70                  75                  80  
Tyr Leu Ser Leu Tyr Asp Gly His Pro His Pro Thr Asn Phe Arg Thr
                85                  90                  95      
Arg Leu Thr Gly Phe His Leu Pro Pro Pro Val Thr Ser Thr Lys Ser
            100                 105                 110         
Val Phe Ser Leu Arg Leu Thr Ser Asp Phe Ala Val Ser Ala His Gly
        115                 120                 125             
Phe Lys Val Tyr Tyr Glu Glu Leu Gln Ser Ser Ser Cys Gly Asn Pro
    130                 135                 140                 
Gly Val Pro Pro Lys Gly Val Leu Tyr Gly Thr Arg Phe Asp Val Gly
145                 150                 155                 160 
Asp Lys Ile Arg Tyr Ser Cys Val Thr Gly Tyr Ile Leu Asp Gly His
                165                 170                 175     
Pro Gln Leu Thr Cys Ile Ala Asn Ser Val Asn Thr Ala Ser Trp Asp
            180                 185                 190         
Phe Pro Val Pro Ile Cys Arg Ala Glu Asp Ala Cys Gly Gly Thr Met
        195                 200                 205             
Arg Gly Ser Ser Gly Ile Ile Ser Ser Pro Ser Phe Pro Asn Glu Tyr
    210                 215                 220                 
His Asn Asn Ala Asp Cys Thr Trp Thr Ile Val Ala Glu Pro Gly Asp
225                 230                 235                 240 
Thr Ile Ser Leu Ile Phe Thr Asp Phe Gln Met Glu Glu Lys Tyr Asp
                245                 250                 255     
Tyr Leu Glu Ile Glu Gly Ser Glu Pro Pro Thr Ile Trp Leu Ser Gly
            260                 265                 270         
Met Asn Ile Pro Pro Pro Ile Ile Ser Asn Lys Asn Trp Leu Arg Leu
        275                 280                 285             
His Phe Val Thr Asp Ser Asn His Arg Tyr Arg Gly Phe Ser Ala Pro
    290                 295                 300                 
Tyr Gln Gly Ser Ser Thr Leu Thr His Thr Thr Ser Thr Gly Glu Leu
305                 310                 315                 320 
Glu Glu His Asn Arg Thr Thr Thr Gly Ala Ile Ala Val Ala Ser Thr
                325                 330                 335     
Pro Ala Asp Val Thr Val Ser Ser Val Thr Ala Val Thr Ile His Arg
            340                 345                 350         
Leu Ser Glu Glu Gln Arg Val Gln Val Thr Ser Leu Arg Asn Ser Gly
        355                 360                 365             
Leu Asp Pro Asn Thr Ser Lys Asp Gly Leu Ser Pro His Pro Ala Asp
    370                 375                 380                 
Thr Gln Ser Thr Arg Arg Arg Pro Arg His Ala Glu Gln Ile Glu Arg
385                 390                 395                 400 
Thr Lys Glu Leu Ala Val Val Thr His Arg Val Lys Lys Ala Ile Asp
                405                 410                 415     
Phe Lys Ser Arg Gly Phe Lys Leu Phe Pro Gly Lys Asp Asn Ser Asn
            420                 425                 430         
Lys Phe Ser Ile Leu Asn Glu Gly Gly Ile Lys Thr Ala Ser Asn Leu
        435                 440                 445             
Cys Pro Asp Pro Gly Glu Pro Glu Asn Gly Lys Arg Ile Gly Ser Asp
    450                 455                 460                 
Phe Ser Leu Gly Ser Thr Val Gln Phe Ser Cys Asp Glu Asp Tyr Val
465                 470                 475                 480 
Leu Gln Gly Ala Lys Ser Ile Thr Cys Gln Arg Ile Ala Glu Val Phe
                485                 490                 495     
Ala Ala Trp Ser Asp His Arg Pro Val Cys Lys Val Lys Thr Cys Gly
            500                 505                 510         
Ser Asn Leu Gln Gly Pro Ser Gly Thr Phe Thr Ser Pro Asn Phe Pro
        515                 520                 525             
Phe Gln Tyr Asp Ser Asn Ala Gln Cys Val Trp Val Ile Thr Ala Val
    530                 535                 540                 
Asn Thr Asn Lys Val Ile Gln Ile Asn Phe Glu Glu Phe Asp Leu Glu
545                 550                 555                 560 
Ile Gly Tyr Asp Thr Leu Thr Ile Gly Asp Gly Gly Glu Val Gly Asp
                565                 570                 575     
Pro Arg Thr Val Leu Gln Val Leu Thr Gly Ser Phe Val Pro Asp Leu
            580                 585                 590         
Ile Val Ser Met Ser Ser Gln Met Trp Leu His Leu Gln Thr Asp Glu
        595                 600                 605             
Ser Val Gly Ser Val Gly Phe Lys Val Asn Tyr Lys Glu Ile Glu Lys
    610                 615                 620                 
Glu Ser Cys Gly Asp Pro Gly Thr Pro Leu Tyr Gly Ile Arg Glu Gly
625                 630                 635                 640 
Asp Gly Phe Ser Asn Arg Asp Val Leu Arg Phe Glu Cys Gln Phe Gly
                645                 650                 655     
Phe Glu Leu Ile Gly Glu Lys Ser Ile Val Cys Gln Glu Asn Asn Gln
            660                 665                 670         
Trp Ser Ala Asn Ile Pro Ile Cys Ile Phe Pro Cys Leu Ser Asn Phe
        675                 680                 685             
Thr Ala Pro Met Gly Thr Val Leu Ser Pro Asp Tyr Pro Glu Gly Tyr
    690                 695                 700                 
Gly Asn Asn Leu Asn Cys Ile Trp Thr Ile Ile Ser Asp Pro Gly Ser
705                 710                 715                 720 
Arg Ile His Leu Ser Phe Asn Asp Phe Asp Leu Glu Ser Gln Phe Asp
                725                 730                 735     
Phe Leu Ala Val Lys Asp Gly Asp Ser Pro Glu Ser Pro Ile Leu Gly
            740                 745                 750         
Thr Phe Thr Gly Ala Glu Val Pro Ser His Leu Thr Ser Asn Ser His
        755                 760                 765             
Ile Leu Arg Leu Glu Phe Gln Ala Asp His Ser Met Ser Gly Arg Gly
    770                 775                 780                 
Phe Asn Ile Thr Tyr Asn Thr Phe Gly His Asn Glu Cys Pro Asp Pro
785                 790                 795                 800 
Gly Ile Pro Ile Asn Ala Arg Arg Phe Gly Asp Asn Phe Gln Leu Gly
                805                 810                 815     
Ser Ser Ile Ser Val Ile Cys Glu Glu Gly Phe Ile Lys Thr Gln Gly
            820                 825                 830         
Thr Glu Thr Ile Thr Cys Ile Leu Met Asp Gly Lys Val Met Trp Ser
        835                 840                 845             
Gly Leu Ile Pro Lys Cys Gly Ala Pro Cys Gly Gly His Phe Ser Ala
    850                 855                 860                 
Pro Ser Gly Val Ile Leu Ser Pro Gly Trp Pro Gly Tyr Tyr Lys Asp
865                 870                 875                 880 
Ser Leu Asn Cys Glu Trp Val Ile Glu Ala Glu Pro Gly His Ser Ile
                885                 890                 895     
Lys Ile Thr Phe Glu Arg Phe Gln Thr Glu Leu Asn Tyr Asp Val Leu
            900                 905                 910         
Glu Val His Asp Gly Pro Asn Leu Leu Ser Pro Leu Leu Gly Ser Tyr
        915                 920                 925             
Asn Gly Thr Gln Val Pro Gln Phe Leu Phe Ser Ser Ser Asn Phe Ile
    930                 935                 940                 
Tyr Leu Leu Phe Thr Thr Asp Asn Ser Arg Ser Asn Asn Gly Phe Lys
945                 950                 955                 960 
Ile His Tyr Glu Ser Val Thr Val Asn Thr Tyr Ser Cys Leu Asp Pro
                965                 970                 975     
Gly Ile Pro Val His Gly Arg Arg Tyr Gly His Asp Phe Ser Ile Gly
            980                 985                 990         
Ser Thr Val Ser Phe Ser Cys Asp Ser Gly Tyr Arg Leu Ser His Glu
        995                 1000                1005            
Glu Pro Leu Leu Cys Glu Lys Asn His Trp Trp Ser His Pro Leu Pro
    1010                1015                1020                
Thr Cys Asp Ala Leu Cys Gly Gly Asp Val Arg Gly Pro Ser Gly Thr
1025                1030                1035                1040
Ile Leu Ser Pro Gly Tyr Pro Glu Phe Tyr Pro Asn Ser Leu Asn Cys
                1045                1050                1055    
Thr Trp Thr Val Asp Val Thr His Gly Lys Gly Val Gln Phe Asn Phe
            1060                1065                1070        
His Thr Phe His Leu Glu Asp His His Asp Tyr Leu Leu Ile Thr Glu
        1075                1080                1085            
Asn Gly Ser Phe Thr Gln Pro Leu Ala Arg Leu Thr Gly Ser Asp Leu
    1090                1095                1100                
Pro Pro Thr Ile Asn Ala Gly Leu Tyr Gly Asn Phe Arg Ala Gln Leu
1105                1110                1115                1120
Arg Phe Ile Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn Ile Thr
                1125                1130                1135    
Phe Ser Glu Tyr Asn Leu Glu Pro Cys Glu Asp Pro Gly Ile Pro Gln
            1140                1145                1150        
Tyr Gly Ser Arg Ile Gly Phe Asn Phe Gly Ile Gly Asp Thr Leu Thr
        1155                1160                1165            
Phe Ser Cys Ser Ser Gly Tyr Arg Leu Glu Gly Thr Ser Glu Ile Ile
    1170                1175                1180                
Cys Leu Gly Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys
1185                1190                1195                1200
Val Ala Glu Cys Gly Ala Ser Ala Thr Asn Asn Glu Gly Ile Leu Leu
                1205                1210                1215    
Ser Pro Asn Tyr Pro Leu Asn Tyr Glu Asn Asn His Glu Cys Ile Tyr
            1220                1225                1230        
Ser Ile Gln Val Gln Ala Gly Lys Gly Ile Asn Ile Ser Ala Arg Thr
        1235                1240                1245            
Phe His Leu Ala Gln Gly Asp Val Leu Lys Ile Tyr Asp Gly Lys Asp
    1250                1255                1260                
Lys Thr Thr His Leu Leu Gly Ala Phe Thr Gly Ala Ser Met Arg Gly
1265                1270                1275                1280
Leu Thr Leu Ser Ser Thr Ser Asn Gln Leu Trp Leu Glu Phe Asn Ser
                1285                1290                1295    
Asp Thr Glu Gly Thr Asp Glu Gly Phe Gln Leu Val Tyr Thr Ser Phe
            1300                1305                1310        
Glu Leu Ser His Cys Glu Asp Pro Gly Ile Pro Gln Phe Gly Tyr Lys
        1315                1320                1325            
Ile Ser Asp Gln Gly His Phe Ala Gly Ser Thr Ile Ile Tyr Gly Cys
    1330                1335                1340                
Asn Pro Gly Tyr Thr Leu His Gly Ser Ser Leu Leu Lys Cys Met Thr
1345                1350                1355                1360
Gly Glu Arg Arg Ala Trp Asp Tyr Pro Leu Pro Ser Cys Ile Ala Glu
                1365                1370                1375    
Cys Gly Gly Arg Phe Lys Gly Glu Ser Ser Gly Arg Ile Leu Ser Pro
            1380                1385                1390        
Gly Tyr Pro Phe Pro Tyr Asp Asn Asn Leu Arg Cys Met Trp Met Ile
        1395                1400                1405            
Glu Val Asp Pro Gly Asn Ile Val Ser Leu Gln Phe Leu Ala Phe Asp
    1410                1415                1420                
Thr Glu Ala Ser His Asp Ile Leu Arg Val Trp Asp Gly Pro Pro Glu
1425                1430                1435                1440
Asn Asp Met Leu Leu Lys Glu Ile Ser Gly Ser Leu Ile Pro Glu Gly
                1445                1450                1455    
Ile His Ser Thr Leu Asn Ile Val Thr Ile Gln Phe Asp Thr Asp Phe
            1460                1465                1470        
Tyr Ile Ser Lys Ser Gly Phe Ala Ile Gln Phe Ser Ser Ser Val Ala
        1475                1480                1485            
Thr Ala Cys Arg Asp Pro Gly Val Pro Met Asn Gly Thr Arg Asn Gly
    1490                1495                1500                
Asp Gly Arg Glu Pro Gly Asp Thr Val Val Phe Gln Cys Asp Pro Gly
1505                1510                1515                1520
Tyr Glu Leu Gln Gly Glu Glu Arg Ile Thr Cys Ile Gln Val Glu Asn
                1525                1530                1535    
Arg Tyr Phe Trp Gln Pro Ser Pro Pro Val Cys Ile Ala Pro Cys Gly
            1540                1545                1550        
Gly Asn Leu Thr Gly Ser Ser Gly Phe Ile Leu Ser Pro Asn Phe Pro
        1555                1560                1565            
His Pro Tyr Pro His Ser Arg Asp Cys Asp Trp Thr Ile Thr Val Asn
    1570                1575                1580                
Ala Asp Tyr Val Ile Ser Leu Ala Phe Ile Ser Phe Ser Ile Glu Pro
1585                1590                1595                1600
Asn Tyr Asp Phe Leu Tyr Ile Tyr Asp Gly Pro Asp Ser Asn Ser Pro
                1605                1610                1615    
Leu Ile Gly Ser Phe Gln Asp Ser Lys Leu Pro Glu Arg Ile Glu Ser
            1620                1625                1630        
Ser Ser Asn Thr Met His Leu Ala Phe Arg Ser Asp Gly Ser Val Ser
        1635                1640                1645            
Tyr Thr Gly Phe His Leu Glu Tyr Lys Ala Lys Leu Arg Glu Ser Cys
    1650                1655                1660                
Phe Asp Pro Gly Asn Ile Met Asn Gly Thr Arg Leu Gly Met Asp Tyr
1665                1670                1675                1680
Lys Leu Gly Ser Thr Val Thr Tyr Tyr Cys Asp Ala Gly Tyr Val Leu
                1685                1690                1695    
Gln Gly Tyr Ser Thr Leu Thr Cys Ile Met Gly Asp Asp Gly Arg Pro
            1700                1705                1710        
Gly Trp Asn Arg Ala Leu Pro Ser Cys His Ala Pro Cys Gly Ser Arg
        1715                1720                1725            
Ser Thr Gly Ser Glu Gly Thr Val Leu Ser Pro Asn Tyr Pro Lys Asn
    1730                1735                1740                
Tyr Ser Val Gly His Asn Cys Val Tyr Ser Ile Ala Val Pro Lys Glu
1745                1750                1755                1760
Phe Val Val Phe Gly Gln Phe Val Phe Phe Gln Thr Ser Leu His Asp
                1765                1770                1775    
Val Val Glu Val Tyr Asp Gly Pro Thr Gln Gln Ser Ser Leu Leu Ser
            1780                1785                1790        
Ser Leu Ser Gly Ser His Ser Gly Glu Ser Leu Pro Leu Ser Ser Gly
        1795                1800                1805            
Asn Gln Ile Thr Ile Arg Phe Thr Ser Val Gly Pro Ile Thr Ala Lys
    1810                1815                1820                
Gly Phe His Phe Val Tyr Gln Ala Val Pro Arg Thr Ser Ser Thr Gln
1825                1830                1835                1840
Cys Ser Ser Val Pro Glu Pro Arg Phe Gly Arg Arg Ile Gly Asn Glu
                1845                1850                1855    
Phe Ala Val Gly Ser Ser Val Leu Phe Asp Cys Asn Pro Gly Tyr Ile
            1860                1865                1870        
Leu His Gly Ser Ile Ala Ile Arg Cys Glu Thr Val Pro Asn Ser Leu
        1875                1880                1885            
Ala Gln Trp Asn Asp Ser Leu Pro Thr Cys Ile Val Pro Cys Gly Gly
    1890                1895                1900                
Ile Leu Thr Lys Arg Lys Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu
1905                1910                1915                1920
Pro Tyr Asp Asn Asn Leu Asn Cys Val Trp Lys Ile Thr Val Pro Glu
                1925                1930                1935    
Gly Ala Gly Ile Gln Val Gln Val Val Ser Phe Ala Thr Glu His Asn
            1940                1945                1950        
Trp Asp Ser Leu Asp Phe Tyr Asp Gly Gly Asp Asn Asn Ala Pro Arg
        1955                1960                1965            
Leu Gly Ser Tyr Ser Gly Thr Thr Ile Pro His Leu Leu Asn Ser Thr
    1970                1975                1980                
Ser Asn Asn Leu Tyr Leu Asn Phe Gln Ser Asp Ile Ser Val Ser Ala
1985                1990                1995                2000
Ala Gly Phe His Leu Glu Tyr Thr Ala Ile Gly Leu Asp Ser Cys Pro
                2005                2010                2015    
Glu Pro Gln Thr Pro Ser Ser Gly Ile Lys Ile Gly Asp Arg Tyr Met
            2020                2025                2030        
Val Gly Asp Val Val Ser Phe Gln Cys Asp Gln Gly Tyr Ser Leu Gln
        2035                2040                2045            
Gly His Ser His Ile Thr Cys Met Pro Gly Pro Val Arg Arg Trp Asn
    2050                2055                2060                
Tyr Pro Ile Pro Ile Cys Leu Ala Gln Cys Gly Gly Ala Met Ser Asp
2065                2070                2075                2080
Phe Ser Gly Val Ile Leu Ser Pro Gly Phe Pro Gly Asn Tyr Pro Ser
                2085                2090                2095    
Ser Leu Asp Cys Thr Trp Thr Ile Asn Leu Pro Ile Gly Phe Gly Val
            2100                2105                2110        
His Leu Gln Phe Val Asn Phe Ser Thr Glu Thr Ile His Asp Tyr Leu
        2115                2120                2125            
Glu Val Arg Ser Gly Ser Ser Glu Thr Ser Thr Val Ile Gly Arg Leu
    2130                2135                2140                
Ser Gly Pro Gln Ile Pro Ser Ser Leu Phe Ser Thr Thr His Glu Thr
2145                2150                2155                2160
Ser Leu Tyr Phe His Ser Asp Tyr Ser Gln Asn Lys Gln Gly Phe His
                2165                2170                2175    
Ile Val Tyr Gln Ala Tyr Gln Leu Gln Ser Cys Pro Asp Pro Arg Pro
            2180                2185                2190        
Phe Arg Asn Gly Phe Val Ile Gly Asn Asp Phe Thr Val Gly Gln Thr
        2195                2200                2205            
Ile Ser Phe Glu Cys Phe Pro Gly Tyr Thr Leu Ile Gly Asn Ser Ala
    2210                2215                2220                
Leu Thr Cys Leu His Gly Val Ser Arg Asn Trp Asn His Pro Leu Pro
2225                2230                2235                2240
Arg Cys Glu Ala Leu Cys Gly Gly Asn Ile Thr Ala Met Asn Gly Thr
                2245                2250                2255    
Ile Tyr Ser Pro Gly Tyr Pro Asp Glu Tyr Pro Asn Phe Gln Asp Cys
            2260                2265                2270        
Phe Trp Leu Val Arg Val Pro Pro Gly Asn Gly Ile Tyr Ile Asn Phe
        2275                2280                2285            
Thr Val Leu Gln Thr Glu Pro Ile Tyr Asp Phe Ile Thr Val Trp Asp
    2290                2295                2300                
Gly Pro Asp Gln Asn Ser Pro Gln Ile Gly Gln Phe Ser Gly Asn Thr
2305                2310                2315                2320
Ala Leu Glu Ser Val Tyr Ser Thr Ser Asn Gln Ile Leu Ile Lys Phe
                2325                2330                2335    
His Ser Asp Phe Thr Thr Ser Gly Phe Phe Val Leu Ser Tyr His Ala
            2340                2345                2350        
Tyr Gln Leu Arg Val Cys Gln Pro Pro Pro Pro Val Pro Asn Ala Glu
        2355                2360                2365            
Ile Leu Thr Glu Asp Asp Glu Phe Glu Ile Gly Asp Ile Ile Arg Tyr
    2370                2375                2380                
Gln Cys Leu Pro Gly Phe Thr Leu Val Gly Asn Ala Ile Leu Thr Cys
2385                2390                2395                2400
Arg Leu Gly Glu Arg Leu Gln Met Asp Gly Ala Pro Pro Val Cys Gln
                2405                2410                2415    
Val Leu Cys Pro Ala Asn Glu Leu Arg Leu Asp Ser Thr Gly Val Ile
            2420                2425                2430        
Leu Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Asn Leu Gln Met Cys Ala
        2435                2440                2445            
Trp Ser Ile Ser Val Glu Lys Gly Tyr Asn Ile Thr Met Phe Val Glu
    2450                2455                2460                
Phe Phe Gln Thr Glu Lys Glu Phe Asp Val Leu Gln Val Tyr Asp Gly
2465                2470                2475                2480
Pro Asn Ile Gln Ser Pro Val Leu Ile Ser Leu Ser Gly Asp Tyr Ser
                2485                2490                2495    
Ser Ala Phe Asn Ile Thr Ser Asn Gly His Glu Val Phe Leu Gln Trp
            2500                2505                2510        
Ser Ala Asp His Gly Asn Asn Lys Lys Gly Phe Arg Ile Arg Tyr Ile
        2515                2520                2525            
Ala Phe Tyr Cys Ser Thr Pro Glu Ser Pro Pro His Gly Tyr Ile Ile
    2530                2535                2540                
Ser Gln Thr Gly Gly Gln Leu Asn Ser Val Val Arg Trp Ala Cys Asp
2545                2550                2555                2560
Arg Gly Phe Arg Leu Val Gly Lys Ser Ser Ala Val Cys Arg Lys Ser
                2565                2570                2575    
Ser Tyr Gly Tyr His Ala Trp Asp Ala Pro Val Pro Ala Cys Gln Gly
            2580                2585                2590        
Glu Val Tyr Tyr Ala Lys Met Asn Lys Asn Met Asn Val Arg Leu Ala
        2595                2600                2605            
Pro Phe Asn Val Phe Ile Trp Ile Thr Asn Phe Ser Glu Asn Gly Asn
    2610                2615                2620                
Ile Arg Lys His Ile Val Asn Ser Phe His Lys Asn Lys Ala
2625                2630                2635            


<210> 9342
<211> 337
<212> PRT
<213> Homo sapiens

<400> 9342
Met Arg Ala Val Phe Ile Gln Gly Ala Glu Glu His Pro Ala Ala Phe
 1               5                  10                  15      
Cys Tyr Gln Val Asn Gly Ser Cys Pro Arg Thr Val His Thr Leu Gly
            20                  25                  30          
Ile Gln Leu Val Ile Tyr Leu Thr Cys Ala Ala Gly Met Leu Ile Ile
        35                  40                  45              
Val Leu Gly Asn Val Phe Val Ala Phe Ala Val Ser Tyr Phe Lys Ala
    50                  55                  60                  
Leu His Thr Pro Thr Asn Phe Leu Leu Leu Ser Leu Ala Leu Ala Asp
65                  70                  75                  80  
Met Phe Leu Gly Leu Leu Val Leu Pro Leu Ser Thr Ile Arg Ser Val
                85                  90                  95      
Glu Ser Cys Trp Phe Phe Gly Asp Phe Leu Cys Arg Leu His Thr Tyr
            100                 105                 110         
Leu Asp Thr Leu Phe Cys Leu Thr Ser Ile Phe His Leu Cys Phe Ile
        115                 120                 125             
Ser Ile Asp Arg His Cys Ala Ile Cys Asp Pro Leu Leu Tyr Pro Ser
    130                 135                 140                 
Lys Phe Thr Val Arg Val Ala Leu Arg Tyr Ile Leu Ala Gly Trp Gly
145                 150                 155                 160 
Val Pro Ala Ala Tyr Thr Ser Leu Phe Leu Tyr Thr Asp Val Val Glu
                165                 170                 175     
Thr Arg Leu Ser Gln Trp Leu Glu Glu Met Pro Cys Val Gly Ser Cys
            180                 185                 190         
Gln Leu Leu Leu Asn Lys Phe Trp Gly Trp Leu Asn Phe Pro Leu Phe
        195                 200                 205             
Phe Val Pro Cys Leu Ile Met Ile Ser Leu Tyr Val Lys Ile Phe Val
    210                 215                 220                 
Val Ala Thr Arg Gln Ala Gln Gln Ile Thr Thr Leu Ser Lys Ser Leu
225                 230                 235                 240 
Ala Gly Ala Ala Lys His Glu Arg Lys Ala Ala Lys Thr Leu Gly Ile
                245                 250                 255     
Val Val Gly Ile Tyr Leu Leu Cys Trp Leu Pro Phe Thr Ile Asp Thr
            260                 265                 270         
Met Val Asp Ser Leu Leu His Phe Ile Thr Pro Pro Leu Val Phe Asp
        275                 280                 285             
Ile Phe Ile Trp Phe Ala Tyr Phe Asn Ser Ala Cys Asn Pro Ile Ile
    290                 295                 300                 
Tyr Val Phe Ser Tyr Gln Trp Phe Arg Lys Ala Leu Lys Leu Thr Leu
305                 310                 315                 320 
Ser Gln Lys Val Phe Ser Pro Gln Thr Arg Thr Val Asp Leu Tyr Gln
                325                 330                 335     
Glu
    


<210> 9343
<211> 877
<212> PRT
<213> Homo sapiens

<400> 9343
Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser Lys Gly
 1               5                  10                  15      
Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu Ile Lys
            20                  25                  30          
Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn Glu Lys
        35                  40                  45              
Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg Gly Ile
    50                  55                  60                  
Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn Lys Asp
65                  70                  75                  80  
Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu Asp Thr
                85                  90                  95      
Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe Val Arg
            100                 105                 110         
Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro Asp Gly
        115                 120                 125             
Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly Val Ile
    130                 135                 140                 
Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu Leu Arg
145                 150                 155                 160 
Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu
                165                 170                 175     
Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp
            180                 185                 190         
Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp
        195                 200                 205             
Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly
    210                 215                 220                 
Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys Ile Ala
225                 230                 235                 240 
Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr Asp Ser
                245                 250                 255     
Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val Val Leu
            260                 265                 270         
Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala Ser Arg
        275                 280                 285             
Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Gln
    290                 295                 300                 
Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala Ile Thr
305                 310                 315                 320 
Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr Phe Gln
                325                 330                 335     
Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg Asp Phe
            340                 345                 350         
Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn His Arg
        355                 360                 365             
Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr Glu Gln
    370                 375                 380                 
Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met Ala His
385                 390                 395                 400 
Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr Lys Leu
                405                 410                 415     
Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys Asp Tyr
            420                 425                 430         
Leu Leu Lys Ile Asn Phe Thr Ala Pro Phe Asn Pro Asn Lys Asp Ala
        435                 440                 445             
Asp Ser Ile Val Lys Phe Asp Thr Phe Gly Asp Gly Met Gly Arg Tyr
    450                 455                 460                 
Asn Val Phe Asn Phe Gln Asn Val Gly Gly Lys Tyr Ser Tyr Leu Lys
465                 470                 475                 480 
Val Gly His Trp Ala Glu Thr Leu Ser Leu Asp Val Asn Ser Ile His
                485                 490                 495     
Trp Ser Arg Asn Ser Val Pro Thr Ser Gln Cys Ser Asp Pro Cys Ala
            500                 505                 510         
Pro Asn Glu Met Lys Asn Met Gln Pro Gly Asp Val Cys Cys Trp Ile
        515                 520                 525             
Cys Ile Pro Cys Glu Pro Tyr Glu Tyr Leu Ala Asp Glu Phe Thr Cys
    530                 535                 540                 
Met Asp Cys Gly Ser Gly Gln Trp Pro Thr Ala Asp Leu Thr Gly Cys
545                 550                 555                 560 
Tyr Asp Leu Pro Glu Asp Tyr Ile Arg Trp Glu Asp Ala Trp Ala Ile
                565                 570                 575     
Gly Pro Val Thr Ile Ala Cys Leu Gly Phe Met Cys Thr Cys Met Val
            580                 585                 590         
Val Thr Val Phe Ile Lys His Asn Asn Thr Pro Leu Val Lys Ala Ser
        595                 600                 605             
Gly Arg Glu Leu Cys Tyr Ile Leu Leu Phe Gly Val Gly Leu Ser Tyr
    610                 615                 620                 
Cys Met Thr Phe Phe Phe Ile Ala Lys Pro Ser Pro Val Ile Cys Ala
625                 630                 635                 640 
Leu Arg Arg Leu Gly Leu Gly Ser Ser Phe Ala Ile Cys Tyr Ser Ala
                645                 650                 655     
Leu Leu Thr Lys Thr Asn Cys Ile Ala Arg Ile Phe Asp Gly Val Lys
            660                 665                 670         
Asn Gly Ala Gln Arg Pro Lys Phe Ile Ser Pro Ser Ser Gln Val Phe
        675                 680                 685             
Ile Cys Leu Gly Leu Ile Leu Val Gln Ile Val Met Val Ser Val Trp
    690                 695                 700                 
Leu Ile Leu Glu Ala Pro Gly Thr Arg Arg Tyr Thr Leu Ala Glu Lys
705                 710                 715                 720 
Arg Glu Thr Val Ile Leu Lys Cys Asn Val Lys Asp Ser Ser Met Leu
                725                 730                 735     
Ile Ser Leu Thr Tyr Asp Val Ile Leu Val Ile Leu Cys Thr Val Tyr
            740                 745                 750         
Ala Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala Lys Phe
        755                 760                 765             
Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Leu
    770                 775                 780                 
Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr Thr Thr
785                 790                 795                 800 
Met Cys Ile Ser Val Ser Leu Ser Gly Phe Val Val Leu Gly Cys Leu
                805                 810                 815     
Phe Ala Pro Lys Val His Ile Ile Leu Phe Gln Pro Gln Lys Asn Val
            820                 825                 830         
Val Thr His Arg Leu His Leu Asn Arg Phe Ser Val Ser Gly Thr Gly
        835                 840                 845             
Thr Thr Tyr Ser Gln Ser Ser Ala Ser Thr Tyr Val Pro Thr Val Cys
    850                 855                 860                 
Asn Gly Arg Glu Val Leu Asp Ser Thr Thr Ser Ser Leu
865                 870                 875         


<210> 9344
<211> 382
<212> PRT
<213> Homo sapiens

<400> 9344
Met Arg Ser Ala Ala Arg Arg Gly Arg Ala Ala Pro Ala Ala Arg Asp
 1               5                  10                  15      
Ser Leu Pro Val Leu Leu Phe Leu Cys Leu Leu Leu Lys Thr Cys Glu
            20                  25                  30          
Pro Lys Thr Ala Asn Ala Phe Lys Pro Asn Ile Leu Leu Ile Met Ala
        35                  40                  45              
Asp Asp Leu Gly Thr Gly Asp Leu Gly Cys Tyr Gly Asn Asn Thr Leu
    50                  55                  60                  
Arg Thr Pro Asn Ile Asp Gln Leu Ala Glu Glu Gly Val Arg Leu Thr
65                  70                  75                  80  
Gln His Leu Ala Ala Ala Pro Leu Cys Thr Pro Ser Arg Ala Ala Phe
                85                  90                  95      
Leu Thr Gly Arg His Ser Phe Arg Ser Gly Met Asp Ala Ser Asn Gly
            100                 105                 110         
Tyr Arg Ala Leu Gln Trp Asn Ala Gly Ser Gly Gly Leu Pro Glu Asn
        115                 120                 125             
Glu Thr Thr Phe Ala Arg Ile Leu Gln Gln His Gly Tyr Ala Thr Gly
    130                 135                 140                 
Leu Ile Gly Lys Trp His Gln Gly Val Asn Cys Ala Ser Arg Gly Asp
145                 150                 155                 160 
His Cys His His Pro Leu Asn His Gly Phe Asp Tyr Phe Tyr Gly Met
                165                 170                 175     
Pro Phe Thr Leu Thr Asn Asp Cys Asp Pro Gly Arg Pro Pro Glu Val
            180                 185                 190         
Asp Ala Ala Leu Arg Ala Gln Leu Trp Gly Tyr Thr Gln Phe Leu Ala
        195                 200                 205             
Leu Gly Ile Leu Thr Leu Ala Ala Gly Gln Thr Cys Gly Phe Phe Cys
    210                 215                 220                 
Val Ser Ala Arg Ala Val Thr Gly Met Ala Gly Val Gly Cys Leu Phe
225                 230                 235                 240 
Phe Ile Ser Trp Tyr Ser Ser Phe Gly Phe Val Arg Arg Trp Asn Cys
                245                 250                 255     
Ile Leu Met Arg Asn His Asp Val Thr Glu Gln Pro Met Val Leu Glu
            260                 265                 270         
Lys Thr Ala Ser Leu Met Leu Lys Glu Ala Val Ser Tyr Ile Glu Arg
        275                 280                 285             
His Lys His Gly Pro Phe Leu Leu Phe Leu Ser Leu Leu His Val His
    290                 295                 300                 
Ile Pro Leu Val Thr Thr Ser Ala Phe Leu Gly Lys Ser Gln His Gly
305                 310                 315                 320 
Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Leu Ile Ala Ser Asp
                325                 330                 335     
Phe Met Ser Ser Ser Glu Val Thr Glu Ser Glu Ala Ile Lys Leu Met
            340                 345                 350         
Phe Arg Thr Met Gln Arg Arg Cys Leu Pro Ser Met Ala Phe Lys Lys
        355                 360                 365             
Pro Trp Arg Gly Pro Val Arg Leu Gln Ile Leu Lys Arg Ala
    370                 375                 380         


<210> 9345
<211> 593
<212> PRT
<213> Homo sapiens

<400> 9345
Met Arg Ser Ala Ala Arg Arg Gly Arg Ala Ala Pro Ala Ala Arg Asp
 1               5                  10                  15      
Ser Leu Pro Val Leu Leu Phe Leu Cys Leu Leu Leu Lys Thr Cys Glu
            20                  25                  30          
Pro Lys Thr Ala Asn Ala Phe Lys Pro Asn Ile Leu Leu Ile Met Ala
        35                  40                  45              
Asp Asp Leu Gly Thr Gly Asp Leu Gly Cys Tyr Gly Asn Asn Thr Leu
    50                  55                  60                  
Arg Thr Pro Asn Ile Asp Gln Leu Ala Glu Glu Gly Val Arg Leu Thr
65                  70                  75                  80  
Gln His Leu Ala Ala Ala Pro Leu Cys Thr Pro Ser Arg Ala Ala Phe
                85                  90                  95      
Leu Thr Gly Arg His Ser Phe Arg Ser Gly Met Asp Ala Ser Asn Gly
            100                 105                 110         
Tyr Arg Ala Leu Gln Trp Asn Ala Gly Ser Gly Gly Leu Pro Glu Asn
        115                 120                 125             
Glu Thr Thr Phe Ala Arg Ile Leu Gln Gln His Gly Tyr Ala Thr Gly
    130                 135                 140                 
Leu Ile Gly Lys Trp His Gln Gly Val Asn Cys Ala Ser Arg Gly Asp
145                 150                 155                 160 
His Cys His His Pro Leu Asn His Gly Phe Asp Tyr Phe Tyr Gly Met
                165                 170                 175     
Pro Phe Thr Leu Thr Asn Asp Cys Asp Pro Gly Arg Pro Pro Glu Val
            180                 185                 190         
Asp Ala Ala Leu Arg Ala Gln Leu Trp Gly Tyr Thr Gln Phe Leu Ala
        195                 200                 205             
Leu Gly Ile Leu Thr Leu Ala Ala Gly Gln Thr Cys Gly Phe Phe Ser
    210                 215                 220                 
Val Ser Ala Arg Ala Val Thr Gly Met Ala Gly Val Gly Cys Leu Phe
225                 230                 235                 240 
Phe Ile Ser Trp Tyr Ser Ser Phe Gly Phe Val Arg Arg Trp Asn Cys
                245                 250                 255     
Ile Leu Met Arg Asn His Asp Val Thr Glu Gln Pro Met Val Leu Glu
            260                 265                 270         
Lys Thr Ala Ser Leu Met Leu Lys Glu Ala Val Ser Tyr Ile Glu Arg
        275                 280                 285             
His Lys His Gly Pro Phe Leu Leu Phe Leu Ser Leu Leu His Val His
    290                 295                 300                 
Ile Pro Leu Val Thr Thr Ser Ala Phe Leu Gly Lys Ser Gln His Gly
305                 310                 315                 320 
Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Leu Ile Gly Lys Val
                325                 330                 335     
Leu Asn Ala Ile Glu Asp Asn Gly Leu Lys Asn Ser Thr Phe Thr Tyr
            340                 345                 350         
Phe Thr Ser Asp His Gly Gly His Leu Glu Ala Arg Asp Gly His Ser
        355                 360                 365             
Gln Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly
    370                 375                 380                 
Gly Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe His Trp Pro Gly
385                 390                 395                 400 
Val Leu Pro Ala Gly Arg Val Ile Gly Glu Pro Thr Ser Leu Met Asp
                405                 410                 415     
Val Phe Pro Thr Val Val Gln Leu Val Gly Gly Glu Val Pro Gln Asp
            420                 425                 430         
Arg Val Ile Asp Gly His Ser Leu Val Pro Leu Leu Gln Gly Ala Glu
        435                 440                 445             
Ala Arg Ser Ala His Glu Phe Leu Phe His Tyr Cys Gly Gln His Leu
    450                 455                 460                 
His Ala Ala Arg Trp His Gln Lys Asp Ser Gly Ser Val Trp Lys Val
465                 470                 475                 480 
His Tyr Thr Thr Pro Gln Phe His Pro Glu Glu Arg Gly Leu Leu Thr
                485                 490                 495     
Ala Glu Ala Ser Ala His Ala Glu Trp Gly Gly Val Thr His His Arg
            500                 505                 510         
Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp Pro Ser Glu Ala Arg Pro
        515                 520                 525             
Leu Thr Pro Asp Ser Glu Pro Leu Tyr His Ala Val Ile Ala Arg Val
    530                 535                 540                 
Gly Ala Ala Val Ser Glu His Arg Gln Thr Leu Ser Pro Val Pro Gln
545                 550                 555                 560 
Gln Phe Ser Met Ser Asn Ile Leu Trp Lys Pro Trp Leu Gln Pro Cys
                565                 570                 575     
Cys Gly His Phe Pro Phe Cys Ser Cys His Glu Asp Gly Asp Gly Thr
            580                 585                 590         
Pro
    


<210> 9346
<211> 631
<212> PRT
<213> Homo sapiens

<400> 9346
Leu Gly Ser Gly Gly Gly Gly Arg Thr Val Ser Ser Thr Leu Ser Pro
 1               5                  10                  15      
Gly Leu Gly Pro Arg Gly Gly Glu Gly Gly Arg Gly Gly Gly Gly Gly
            20                  25                  30          
Gly Gly Gly Gly Gly Gly Thr Met Phe Leu His Ser Val Asn Leu Trp
        35                  40                  45              
Asn Leu Ala Phe Tyr Val Phe Met Val Phe Leu Ala Thr Leu Gly Leu
    50                  55                  60                  
Trp Asp Val Phe Phe Gly Phe Glu Glu Asn Lys Cys Ser Met Ser Tyr
65                  70                  75                  80  
Met Phe Glu Tyr Pro Glu Tyr Gln Lys Ile Glu Leu Pro Lys Lys Leu
                85                  90                  95      
Ala Lys Arg Tyr Pro Ala Tyr Glu Leu Tyr Leu Tyr Gly Glu Gly Ser
            100                 105                 110         
Tyr Ala Glu Glu His Lys Ile Leu Pro Leu Thr Gly Ile Pro Val Leu
        115                 120                 125             
Phe Leu Pro Gly Asn Ala Gly Ser Tyr Lys Gln Val Arg Ser Ile Gly
    130                 135                 140                 
Ser Ile Ala Leu Arg Lys Ala Glu Asp Ile Asp Phe Lys Tyr His Phe
145                 150                 155                 160 
Asp Phe Phe Ser Val Asn Phe Asn Glu Glu Leu Val Ala Leu Tyr Gly
                165                 170                 175     
Gly Ser Leu Gln Lys Gln Thr Lys Phe Val His Glu Cys Ile Lys Thr
            180                 185                 190         
Ile Leu Lys Leu Tyr Lys Gly Gln Glu Phe Ala Pro Lys Ser Val Ala
        195                 200                 205             
Ile Ile Gly His Ser Met Gly Gly Leu Val Ala Arg Ala Leu Leu Thr
    210                 215                 220                 
Leu Lys Asn Phe Lys His Asp Leu Ile Asn Leu Leu Ile Thr Gln Ala
225                 230                 235                 240 
Thr Pro His Val Ala Pro Val Met Pro Leu Asp Arg Phe Ile Thr Asp
                245                 250                 255     
Phe Tyr Thr Thr Val Asn Asn Tyr Trp Ile Leu Asn Ala Arg His Ile
            260                 265                 270         
Asn Leu Thr Thr Leu Ser Val Ala Gly Gly Phe Arg Asp Tyr Gln Val
        275                 280                 285             
Arg Ser Gly Leu Thr Phe Leu Pro Lys Leu Ser His His Thr Ser Ala
    290                 295                 300                 
Leu Ser Val Val Ser Ser Ala Val Pro Lys Thr Trp Val Ser Thr Asp
305                 310                 315                 320 
His Leu Ser Ile Val Trp Cys Lys Gln Leu Gln Leu Thr Thr Val Arg
                325                 330                 335     
Ala Phe Phe Asp Leu Ile Asp Ala Asp Thr Lys Gln Ile Thr Gln Asn
            340                 345                 350         
Ser Lys Lys Lys Leu Ser Val Leu Tyr His His Phe Ile Arg His Pro
        355                 360                 365             
Ser Lys His Phe Glu Glu Asn Pro Ala Ile Ile Ser Asp Leu Thr Gly
    370                 375                 380                 
Thr Ser Met Trp Val Leu Val Lys Val Ser Lys Trp Thr Tyr Val Ala
385                 390                 395                 400 
Tyr Asn Glu Ser Glu Lys Ile Tyr Phe Thr Phe Pro Leu Glu Asn His
                405                 410                 415     
Arg Lys Ile Tyr Thr His Val Tyr Cys Gln Ser Thr Met Leu Asp Thr
            420                 425                 430         
Asn Ser Trp Ile Phe Ala Cys Ile Asn Ser Thr Ser Met Cys Leu Gln
        435                 440                 445             
Gly Val Asp Leu Ser Trp Lys Ala Glu Leu Leu Pro Thr Ile Lys Tyr
    450                 455                 460                 
Leu Thr Leu Arg Leu Gln Asp Tyr Pro Ser Leu Ser His Leu Val Val
465                 470                 475                 480 
Tyr Val Pro Ser Val Arg Gly Ser Lys Phe Val Val Asp Cys Glu Phe
                485                 490                 495     
Phe Lys Lys Glu Lys Arg Tyr Ile Gln Leu Pro Val Thr His Leu Phe
            500                 505                 510         
Ser Phe Gly Leu Ser Ser Arg Lys Val Val Leu Asn Thr Asn Gly Leu
        515                 520                 525             
Tyr Tyr Asn Leu Glu Leu Leu Asn Phe Gly Gln Ile Tyr Gln Ala Phe
    530                 535                 540                 
Lys Ile Asn Val Val Ser Lys Cys Ser Ala Val Lys Glu Glu Ile Thr
545                 550                 555                 560 
Ser Ile Tyr Arg Leu His Ile Pro Trp Ser Tyr Glu Asp Ser Leu Thr
                565                 570                 575     
Ile Ala Gln Ala Pro Ser Ser Thr Glu Ile Ser Leu Lys Leu His Ile
            580                 585                 590         
Ala Gln Pro Glu Asn Asn Thr His Val Ala Leu Phe Lys Met Tyr Thr
        595                 600                 605             
Ser Ser Asp Cys Arg Tyr Glu Val Thr Val Lys Thr Ser Phe Ser Gln
    610                 615                 620                 
Ile Leu Gly Gln Val Val Ala
625                 630     


<210> 9347
<211> 1865
<212> PRT
<213> Homo sapiens

<400> 9347
Met Ser Gln Lys Ser Trp Ile Glu Ser Thr Leu Thr Lys Arg Glu Cys
 1               5                  10                  15      
Val Tyr Ile Ile Pro Ser Ser Lys Asp Pro His Arg Cys Leu Pro Gly
            20                  25                  30          
Cys Gln Ile Cys Gln Gln Leu Val Arg Cys Phe Cys Gly Arg Leu Val
        35                  40                  45              
Lys Gln His Ala Cys Phe Thr Ala Ser Leu Ala Met Lys Tyr Ser Asp
    50                  55                  60                  
Val Lys Leu Gly Asp His Phe Asn Gln Ala Ile Glu Glu Trp Ser Val
65                  70                  75                  80  
Glu Lys His Thr Glu Gln Ser Pro Thr Asp Ala Tyr Gly Val Ile Asn
                85                  90                  95      
Phe Gln Gly Gly Ser His Ser Tyr Arg Ala Lys Tyr Val Arg Leu Ser
            100                 105                 110         
Tyr Asp Thr Lys Pro Glu Val Ile Leu Gln Leu Leu Leu Lys Glu Trp
        115                 120                 125             
Gln Met Glu Leu Pro Lys Leu Val Ile Ser Val His Gly Gly Met Gln
    130                 135                 140                 
Lys Phe Glu Leu His Pro Arg Ile Lys Gln Leu Leu Gly Lys Gly Leu
145                 150                 155                 160 
Ile Lys Ala Ala Val Thr Thr Gly Ala Trp Ile Leu Thr Gly Gly Val
                165                 170                 175     
Asn Thr Gly Val Ala Lys His Val Gly Asp Ala Leu Lys Glu His Ala
            180                 185                 190         
Ser Arg Ser Ser Arg Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly
        195                 200                 205             
Val Ile Glu Asn Arg Asn Asp Leu Val Gly Arg Asp Val Val Ala Pro
    210                 215                 220                 
Tyr Gln Thr Leu Leu Asn Pro Leu Ser Lys Leu Asn Val Leu Asn Asn
225                 230                 235                 240 
Leu His Ser His Phe Ile Leu Val Asp Asp Gly Thr Val Gly Lys Tyr
                245                 250                 255     
Gly Ala Glu Val Arg Leu Arg Arg Glu Leu Glu Lys Thr Ile Asn Gln
            260                 265                 270         
Gln Arg Ile His Ala Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu
        275                 280                 285             
Ile Phe Glu Gly Gly Pro Asn Val Ile Leu Thr Val Leu Glu Tyr Leu
    290                 295                 300                 
Gln Glu Ser Pro Pro Val Pro Val Val Val Cys Glu Gly Thr Gly Arg
305                 310                 315                 320 
Ala Ala Asp Leu Leu Ala Tyr Ile His Lys Gln Thr Glu Glu Gly Gly
                325                 330                 335     
Asn Leu Pro Asp Ala Ala Glu Pro Asp Ile Ile Ser Thr Ile Lys Lys
            340                 345                 350         
Thr Phe Asn Phe Gly Gln Asn Glu Ala Leu His Leu Phe Gln Thr Leu
        355                 360                 365             
Met Glu Cys Met Lys Arg Lys Glu Leu Ile Thr Val Phe His Ile Gly
    370                 375                 380                 
Ser Asp Glu His Gln Asp Ile Asp Val Ala Ile Leu Thr Ala Leu Leu
385                 390                 395                 400 
Lys Gly Thr Asn Ala Ser Ala Phe Asp Gln Leu Ile Leu Thr Leu Ala
                405                 410                 415     
Trp Asp Arg Val Asp Ile Ala Lys Asn His Val Phe Val Tyr Gly Gln
            420                 425                 430         
Gln Trp Leu Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val
        435                 440                 445             
Met Asp Arg Val Ala Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser
    450                 455                 460                 
Met His Lys Phe Leu Thr Ile Pro Arg Leu Glu Glu Leu Tyr Asn Thr
465                 470                 475                 480 
Lys Gln Gly Pro Thr Asn Pro Met Leu Phe His Leu Val Arg Asp Val
                485                 490                 495     
Lys Gln Gly Asn Leu Pro Pro Gly Tyr Lys Ile Thr Leu Ile Asp Ile
            500                 505                 510         
Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Thr Tyr Arg Cys Thr Tyr
        515                 520                 525             
Thr Arg Lys Arg Phe Arg Leu Ile Tyr Asn Ser Leu Gly Gly Asn Asn
    530                 535                 540                 
Arg Arg Ser Gly Arg Asn Thr Ser Ser Ser Thr Pro Gln Leu Arg Lys
545                 550                 555                 560 
Ser His Glu Ser Phe Gly Asn Arg Ala Asp Lys Lys Glu Lys Met Arg
                565                 570                 575     
His Asn His Phe Ile Lys Thr Ala Gln Pro Tyr Arg Pro Lys Ile Asp
            580                 585                 590         
Thr Val Met Glu Glu Gly Lys Lys Lys Arg Thr Lys Asp Glu Ile Val
        595                 600                 605             
Asp Ile Asp Asp Pro Glu Thr Lys Arg Phe Pro Tyr Pro Leu Asn Glu
    610                 615                 620                 
Leu Leu Ile Trp Ala Cys Leu Met Lys Arg Gln Val Met Ala Arg Phe
625                 630                 635                 640 
Leu Trp Gln His Gly Glu Glu Ser Met Ala Lys Ala Leu Val Ala Cys
                645                 650                 655     
Lys Ile Tyr Arg Ser Met Ala Tyr Glu Ala Lys Gln Ser Asp Leu Val
            660                 665                 670         
Asp Asp Thr Ser Glu Glu Leu Lys Gln Tyr Ser Asn Asp Phe Gly Gln
        675                 680                 685             
Leu Ala Val Glu Leu Leu Glu Gln Ser Phe Arg Gln Asp Glu Thr Met
    690                 695                 700                 
Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ser Thr
705                 710                 715                 720 
Cys Leu Lys Leu Ala Val Ser Ser Arg Leu Arg Pro Phe Val Ala His
                725                 730                 735     
Thr Cys Thr Gln Met Leu Leu Ser Asp Met Trp Met Gly Arg Leu Asn
            740                 745                 750         
Met Arg Lys Asn Ser Trp Tyr Lys Val Ile Leu Ser Ile Leu Val Pro
        755                 760                 765             
Pro Ala Ile Leu Leu Leu Glu Tyr Lys Thr Lys Ala Glu Met Ser His
    770                 775                 780                 
Ile Pro Gln Ser Gln Asp Ala His Gln Met Thr Met Asp Asp Ser Glu
785                 790                 795                 800 
Asn Asn Phe Gln Asn Ile Thr Glu Glu Ile Pro Met Glu Val Phe Lys
                805                 810                 815     
Glu Val Arg Ile Leu Asp Ser Asn Glu Gly Lys Asn Glu Met Glu Ile
            820                 825                 830         
Gln Met Lys Ser Lys Lys Leu Pro Ile Thr Arg Lys Phe Tyr Ala Phe
        835                 840                 845             
Tyr His Ala Pro Ile Val Lys Phe Trp Phe Asn Thr Leu Ala Tyr Leu
    850                 855                 860                 
Gly Phe Leu Met Leu Tyr Thr Phe Val Val Leu Val Gln Met Glu Gln
865                 870                 875                 880 
Leu Pro Ser Val Gln Glu Trp Ile Val Ile Ala Tyr Ile Phe Thr Tyr
                885                 890                 895     
Ala Ile Glu Lys Val Arg Glu Ile Phe Met Ser Glu Ala Gly Lys Val
            900                 905                 910         
Asn Gln Lys Ile Lys Val Trp Phe Ser Asp Tyr Phe Asn Ile Ser Asp
        915                 920                 925             
Thr Ile Ala Ile Ile Ser Phe Phe Ile Gly Phe Gly Leu Arg Phe Gly
    930                 935                 940                 
Ala Lys Trp Asn Phe Ala Asn Ala Tyr Asp Asn His Val Phe Val Ala
945                 950                 955                 960 
Gly Arg Leu Ile Tyr Cys Leu Asn Ile Ile Phe Trp Tyr Val Arg Leu
                965                 970                 975     
Leu Asp Phe Leu Ala Val Asn Gln Gln Ala Gly Pro Tyr Val Met Met
            980                 985                 990         
Ile Gly Lys Met Val Ala Asn Met Phe Tyr Ile Val Val Ile Met Ala
        995                 1000                1005            
Leu Val Leu Leu Ser Phe Gly Val Pro Arg Lys Ala Ile Leu Tyr Pro
    1010                1015                1020                
His Glu Ala Pro Ser Trp Thr Leu Ala Lys Asp Ile Val Phe His Pro
1025                1030                1035                1040
Tyr Trp Met Ile Phe Gly Glu Val Tyr Ala Tyr Glu Ile Asp Val Cys
                1045                1050                1055    
Ala Asn Asp Ser Val Ile Pro Gln Ile Cys Gly Pro Gly Thr Trp Leu
            1060                1065                1070        
Thr Pro Phe Leu Gln Ala Val Tyr Leu Phe Val Gln Tyr Ile Ile Met
        1075                1080                1085            
Val Asn Leu Leu Ile Ala Phe Phe Asn Asn Val Tyr Leu Gln Val Lys
    1090                1095                1100                
Ala Ile Ser Asn Ile Val Trp Lys Tyr Gln Arg Tyr His Phe Ile Met
1105                1110                1115                1120
Ala Tyr His Glu Lys Pro Val Leu Pro Pro Pro Leu Ile Ile Leu Ser
                1125                1130                1135    
His Ile Val Ser Leu Phe Cys Cys Ile Cys Lys Arg Arg Lys Lys Asp
            1140                1145                1150        
Lys Thr Ser Asp Gly Pro Lys Leu Phe Leu Thr Glu Glu Asp Gln Lys
        1155                1160                1165            
Lys Leu His Asp Phe Glu Glu Gln Cys Val Glu Met Tyr Phe Asn Glu
    1170                1175                1180                
Lys Asp Asp Lys Phe His Ser Gly Ser Glu Glu Arg Ile Arg Val Thr
1185                1190                1195                1200
Phe Glu Arg Val Glu Gln Met Cys Ile Gln Ile Lys Glu Val Gly Asp
                1205                1210                1215    
Arg Val Asn Tyr Ile Lys Arg Ser Leu Gln Ser Leu Asp Ser Gln Ile
            1220                1225                1230        
Gly His Leu Gln Asp Leu Ser Ala Leu Thr Val Asp Thr Leu Lys Thr
        1235                1240                1245            
Leu Thr Ala Gln Lys Ala Ser Glu Ala Ser Lys Val His Asn Glu Ile
    1250                1255                1260                
Thr Arg Glu Leu Ser Ile Ser Lys His Leu Ala Gln Asn Leu Ile Asp
1265                1270                1275                1280
Asp Gly Pro Val Arg Pro Ser Val Trp Lys Lys His Gly Val Val Asn
                1285                1290                1295    
Thr Leu Ser Ser Ser Leu Pro Gln Gly Asp Leu Glu Ser Asn Asn Pro
            1300                1305                1310        
Phe His Cys Asn Ile Leu Met Lys Asp Asp Lys Asp Pro Gln Cys Asn
        1315                1320                1325            
Ile Phe Gly Gln Asp Leu Pro Ala Val Pro Gln Arg Lys Glu Phe Asn
    1330                1335                1340                
Phe Pro Glu Ala Gly Ser Ser Ser Gly Ala Leu Phe Pro Ser Ala Val
1345                1350                1355                1360
Ser Pro Pro Glu Leu Arg Gln Arg Leu His Gly Val Glu Leu Leu Lys
                1365                1370                1375    
Ile Phe Asn Lys Asn Gln Lys Leu Gly Ser Ser Ser Thr Ser Ile Pro
            1380                1385                1390        
His Leu Ser Ser Pro Pro Thr Lys Phe Phe Val Ser Thr Pro Ser Gln
        1395                1400                1405            
Pro Ser Cys Lys Ser His Leu Glu Thr Gly Thr Lys Asp Gln Glu Thr
    1410                1415                1420                
Val Cys Ser Lys Ala Thr Glu Gly Asp Asn Thr Glu Phe Gly Ala Phe
1425                1430                1435                1440
Val Gly His Arg Asp Ser Met Asp Leu Gln Arg Phe Lys Glu Thr Ser
                1445                1450                1455    
Asn Lys Ile Lys Ile Leu Ser Asn Asn Asn Thr Ser Glu Asn Thr Leu
            1460                1465                1470        
Lys Arg Val Ser Ser Leu Ala Gly Phe Thr Asp Cys His Arg Thr Ser
        1475                1480                1485            
Ile Pro Val His Ser Lys Gln Ala Glu Lys Ile Ser Arg Arg Pro Ser
    1490                1495                1500                
Thr Glu Asp Thr His Glu Val Asp Ser Lys Ala Ala Leu Ile Pro Asp
1505                1510                1515                1520
Trp Leu Gln Asp Arg Pro Ser Asn Arg Glu Met Pro Ser Glu Glu Gly
                1525                1530                1535    
Thr Leu Asn Gly Leu Thr Ser Pro Phe Lys Pro Ala Met Asp Thr Asn
            1540                1545                1550        
Tyr Tyr Tyr Ser Ala Val Glu Arg Asn Asn Leu Met Arg Leu Ser Gln
        1555                1560                1565            
Ser Ile Pro Phe Thr Pro Val Pro Pro Arg Gly Glu Pro Val Thr Val
    1570                1575                1580                
Tyr Arg Leu Glu Glu Ser Ser Pro Asn Ile Leu Asn Asn Ser Met Ser
1585                1590                1595                1600
Ser Trp Ser Gln Leu Gly Leu Cys Ala Lys Ile Glu Phe Leu Ser Lys
                1605                1610                1615    
Glu Glu Met Gly Gly Gly Leu Arg Arg Ala Val Lys Val Gln Cys Thr
            1620                1625                1630        
Trp Ser Glu His Asp Ile Leu Lys Ser Gly His Leu Tyr Ile Ile Lys
        1635                1640                1645            
Ser Phe Leu Pro Glu Val Val Asn Thr Trp Ser Ser Ile Tyr Lys Glu
    1650                1655                1660                
Asp Thr Val Leu His Leu Cys Leu Arg Glu Ile Gln Gln Gln Arg Ala
1665                1670                1675                1680
Ala Gln Lys Leu Thr Phe Ala Phe Asn Gln Met Lys Pro Lys Ser Ile
                1685                1690                1695    
Pro Tyr Ser Pro Arg Phe Leu Glu Val Phe Leu Leu Tyr Cys His Ser
            1700                1705                1710        
Ala Gly Gln Trp Phe Ala Val Glu Glu Cys Met Thr Gly Glu Phe Arg
        1715                1720                1725            
Lys Tyr Asn Asn Asn Asn Gly Asp Glu Ile Ile Pro Thr Asn Thr Leu
    1730                1735                1740                
Glu Glu Ile Met Leu Ala Phe Ser His Trp Thr Tyr Glu Tyr Thr Arg
1745                1750                1755                1760
Gly Glu Leu Leu Val Leu Asp Leu Gln Gly Val Gly Glu Asn Leu Thr
                1765                1770                1775    
Asp Pro Ser Val Ile Lys Ala Glu Glu Lys Arg Ser Cys Asp Met Val
            1780                1785                1790        
Phe Gly Pro Ala Asn Leu Gly Glu Asp Ala Ile Lys Asn Phe Arg Ala
        1795                1800                1805            
Lys His His Cys Asn Ser Cys Cys Arg Lys Leu Lys Leu Pro Asp Leu
    1810                1815                1820                
Lys Arg Asn Asp Tyr Thr Pro Asp Lys Ile Ile Phe Pro Gln Asp Glu
1825                1830                1835                1840
Pro Ser Asp Leu Asn Leu Gln Pro Gly Asn Ser Thr Lys Glu Ser Glu
                1845                1850                1855    
Ser Thr Asn Ser Val Arg Leu Met Leu
            1860                1865


<210> 9348
<211> 4967
<212> PRT
<213> Homo sapiens

<400> 9348
Met Ala Asp Gly Gly Glu Gly Glu Asp Glu Ile Gln Phe Leu Arg Thr
 1               5                  10                  15      
Asp Asp Glu Val Val Leu Gln Cys Thr Ala Thr Ile His Lys Glu Gln
            20                  25                  30          
Gln Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe
        35                  40                  45              
Leu Glu Ser Thr Ser Asn Ser Lys Asn Val Pro Pro Asp Leu Ser Ile
    50                  55                  60                  
Cys Thr Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu
65                  70                  75                  80  
Met Leu Ala Asn Thr Val Glu Lys Ser Glu Gly Gln Val Asp Val Glu
                85                  90                  95      
Lys Trp Lys Phe Met Met Lys Thr Ala Gln Gly Gly Gly His Arg Thr
            100                 105                 110         
Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ser Tyr Ser Gly Met
        115                 120                 125             
Tyr Leu Cys Cys Leu Ser Thr Ser Arg Ser Ser Thr Asp Lys Leu Ala
    130                 135                 140                 
Phe Asp Val Gly Leu Gln Glu Asp Thr Thr Gly Glu Ala Cys Trp Trp
145                 150                 155                 160 
Thr Ile His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu Lys Val Arg
                165                 170                 175     
Val Gly Asp Asp Leu Ile Leu Val Ser Val Ser Ser Glu Arg Tyr Leu
            180                 185                 190         
His Leu Ser Tyr Gly Asn Gly Ser Leu His Val Asp Ala Ala Phe Gln
        195                 200                 205             
Gln Thr Leu Trp Ser Val Ala Pro Ile Ser Ser Gly Ser Glu Ala Ala
    210                 215                 220                 
Gln Gly Tyr Leu Ile Gly Gly Asp Val Leu Arg Leu Leu His Gly His
225                 230                 235                 240 
Met Asp Glu Cys Leu Thr Val Pro Ser Gly Glu His Gly Glu Glu Gln
                245                 250                 255     
Arg Arg Thr Val His Tyr Glu Gly Gly Ala Val Ser Val His Ala Arg
            260                 265                 270         
Ser Leu Trp Arg Leu Glu Thr Leu Arg Val Ala Trp Ser Gly Ser His
        275                 280                 285             
Ile Arg Trp Gly Gln Pro Phe Arg Leu Arg His Val Thr Thr Gly Lys
    290                 295                 300                 
Tyr Leu Ser Leu Met Glu Asp Lys Asn Leu Leu Leu Met Asp Lys Glu
305                 310                 315                 320 
Lys Ala Asp Val Lys Ser Thr Ala Phe Thr Phe Arg Ser Ser Lys Glu
                325                 330                 335     
Lys Leu Asp Val Gly Val Arg Lys Glu Val Asp Gly Met Gly Thr Ser
            340                 345                 350         
Glu Ile Lys Tyr Gly Asp Ser Val Cys Tyr Ile Gln His Val Asp Thr
        355                 360                 365             
Gly Leu Trp Leu Thr Tyr Gln Ser Val Asp Val Lys Ser Val Arg Met
    370                 375                 380                 
Gly Ser Ile Gln Arg Lys Ala Ile Met His His Glu Gly His Met Asp
385                 390                 395                 400 
Asp Gly Ile Ser Leu Ser Arg Ser Gln His Glu Glu Ser Arg Thr Ala
                405                 410                 415     
Arg Val Ile Arg Ser Thr Val Phe Leu Phe Asn Arg Phe Ile Arg Gly
            420                 425                 430         
Leu Asp Ala Leu Ser Lys Lys Ala Lys Ala Ser Thr Val Asp Leu Pro
        435                 440                 445             
Ile Glu Ser Val Ser Leu Ser Leu Gln Asp Leu Ile Gly Tyr Phe His
    450                 455                 460                 
Pro Pro Asp Glu His Leu Glu His Glu Asp Lys Gln Asn Arg Leu Arg
465                 470                 475                 480 
Ala Leu Lys Asn Arg Gln Asn Leu Phe Gln Glu Glu Gly Met Ile Asn
                485                 490                 495     
Leu Val Leu Glu Cys Ile Asp Arg Leu His Val Tyr Ser Ser Ala Ala
            500                 505                 510         
His Phe Ala Asp Val Ala Gly Arg Glu Ala Gly Glu Ser Trp Lys Ser
        515                 520                 525             
Ile Leu Asn Ser Leu Tyr Glu Leu Leu Ala Ala Leu Ile Arg Gly Asn
    530                 535                 540                 
Arg Lys Asn Cys Ala Gln Phe Ser Gly Ser Leu Asp Trp Leu Ile Ser
545                 550                 555                 560 
Arg Leu Glu Arg Leu Glu Ala Ser Ser Gly Ile Leu Glu Val Leu His
                565                 570                 575     
Cys Val Leu Val Glu Ser Pro Glu Ala Leu Asn Ile Ile Lys Glu Gly
            580                 585                 590         
His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly Arg Asn His
        595                 600                 605             
Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys His Gly Val Ala
    610                 615                 620                 
Val Arg Ser Asn Gln His Leu Ile Cys Asp Asn Leu Leu Pro Gly Arg
625                 630                 635                 640 
Asp Leu Leu Leu Gln Thr Arg Leu Val Asn His Val Ser Ser Met Arg
                645                 650                 655     
Pro Asn Ile Phe Leu Gly Val Ser Glu Gly Ser Ala Gln Tyr Lys Lys
            660                 665                 670         
Trp Tyr Tyr Glu Leu Met Val Asp His Thr Glu Pro Phe Val Thr Ala
        675                 680                 685             
Glu Ala Thr His Leu Arg Val Gly Trp Ala Ser Thr Glu Gly Tyr Ser
    690                 695                 700                 
Pro Tyr Pro Gly Gly Gly Glu Glu Trp Gly Gly Asn Gly Val Gly Asp
705                 710                 715                 720 
Asp Leu Phe Ser Tyr Gly Phe Asp Gly Leu His Leu Trp Ser Gly Cys
                725                 730                 735     
Ile Ala Arg Thr Val Ser Ser Pro Asn Gln His Leu Leu Arg Thr Asp
            740                 745                 750         
Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Ala Pro Ser Ile Ser Phe
        755                 760                 765             
Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn Phe Asn Ile
    770                 775                 780                 
Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala Gly Ile Lys Val
785                 790                 795                 800 
Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys Phe Leu Pro Pro
                805                 810                 815     
Pro Gly Tyr Ala Pro Cys Tyr Glu Ala Val Leu Pro Lys Glu Lys Leu
            820                 825                 830         
Lys Val Glu His Ser Arg Glu Tyr Lys Gln Glu Arg Thr Tyr Thr Arg
        835                 840                 845             
Asp Leu Leu Gly Pro Thr Val Ser Leu Thr Gln Ala Ala Phe Thr Pro
    850                 855                 860                 
Ile Pro Val Asp Thr Ser Gln Ile Val Leu Pro Pro His Leu Glu Arg
865                 870                 875                 880 
Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu Trp Val Met Asn
                885                 890                 895     
Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg Asp Asp Asn Lys
            900                 905                 910         
Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro Glu Gln Glu
        915                 920                 925             
Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu Lys Thr Leu Leu
    930                 935                 940                 
Ala Leu Gly Cys His Val Gly Ile Ser Asp Glu His Ala Glu Asp Lys
945                 950                 955                 960 
Val Lys Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu Thr Ser Gly Tyr
                965                 970                 975     
Lys Pro Ala Pro Met Asp Leu Ser Phe Ile Lys Leu Thr Pro Ser Gln
            980                 985                 990         
Glu Ala Met Val Asp Lys Leu Ala Glu Asn Ala His Asn Val Trp Ala
        995                 1000                1005            
Arg Asp Arg Ile Arg Gln Gly Trp Thr Tyr Gly Ile Gln Gln Asp Val
    1010                1015                1020                
Lys Asn Arg Arg Asn Pro Arg Leu Val Pro Tyr Thr Pro Leu Asp Asp
1025                1030                1035                1040
Arg Thr Lys Lys Ser Asn Lys Asp Ser Leu Arg Glu Ala Val Arg Thr
                1045                1050                1055    
Leu Leu Gly Tyr Gly Tyr Asn Leu Glu Ala Pro Asp Gln Asp His Ala
            1060                1065                1070        
Ala Arg Ala Glu Val Cys Ser Gly Thr Gly Glu Arg Phe Arg Ile Phe
        1075                1080                1085            
Arg Ala Glu Lys Thr Tyr Ala Val Lys Ala Gly Arg Trp Tyr Phe Glu
    1090                1095                1100                
Phe Glu Thr Val Thr Ala Gly Asp Met Arg Val Gly Trp Ser Arg Pro
1105                1110                1115                1120
Gly Cys Gln Pro Asp Gln Glu Leu Gly Ser Asp Glu Arg Ala Phe Ala
                1125                1130                1135    
Phe Asp Gly Phe Lys Ala Gln Arg Trp His Gln Gly Asn Glu His Tyr
            1140                1145                1150        
Gly Arg Ser Trp Gln Ala Gly Asp Val Val Gly Cys Met Val Asp Met
        1155                1160                1165            
Asn Glu His Thr Met Met Phe Thr Leu Asn Gly Glu Ile Leu Leu Asp
    1170                1175                1180                
Asp Ser Gly Ser Glu Leu Ala Phe Lys Asp Phe Asp Val Gly Asp Gly
1185                1190                1195                1200
Phe Ile Pro Val Cys Ser Leu Gly Val Ala Gln Val Gly Arg Met Asn
                1205                1210                1215    
Phe Gly Lys Asp Val Ser Thr Leu Lys Tyr Phe Thr Ile Cys Gly Leu
            1220                1225                1230        
Gln Glu Gly Tyr Glu Pro Phe Ala Val Asn Thr Asn Arg Asp Ile Thr
        1235                1240                1245            
Met Trp Leu Ser Lys Arg Leu Pro Gln Phe Leu Gln Val Pro Ser Asn
    1250                1255                1260                
His Glu His Ile Glu Val Thr Arg Ile Asp Gly Thr Ile Asp Ser Ser
1265                1270                1275                1280
Pro Cys Leu Lys Val Thr Gln Lys Ser Phe Gly Ser Gln Asn Ser Asn
                1285                1290                1295    
Thr Asp Ile Met Phe Tyr Arg Leu Ser Met Pro Ile Glu Cys Ala Glu
            1300                1305                1310        
Val Phe Ser Lys Thr Val Ala Gly Gly Leu Pro Gly Ala Gly Leu Phe
        1315                1320                1325            
Gly Pro Lys Asn Asp Leu Glu Asp Tyr Asp Ala Asp Ser Asp Phe Glu
    1330                1335                1340                
Val Leu Met Lys Thr Ala His Gly His Leu Val Pro Asp Arg Val Asp
1345                1350                1355                1360
Lys Asp Lys Glu Ala Thr Lys Pro Glu Phe Asn Asn His Lys Asp Tyr
                1365                1370                1375    
Ala Gln Glu Lys Pro Ser Arg Leu Lys Gln Arg Phe Leu Leu Arg Arg
            1380                1385                1390        
Thr Lys Pro Asp Tyr Ser Thr Ser His Ser Ala Arg Leu Thr Glu Asp
        1395                1400                1405            
Val Leu Ala Asp Asp Arg Asp Asp Tyr Asp Phe Leu Met Gln Thr Ser
    1410                1415                1420                
Thr Tyr Tyr Tyr Ser Val Arg Ile Phe Pro Gly Gln Glu Pro Ala Asn
1425                1430                1435                1440
Val Trp Val Gly Trp Ile Thr Ser Asp Phe His Gln Tyr Asp Thr Gly
                1445                1450                1455    
Phe Asp Leu Asp Arg Val Arg Thr Val Thr Val Thr Leu Gly Asp Glu
            1460                1465                1470        
Lys Gly Lys Val His Glu Ser Ile Lys Arg Ser Asn Cys Tyr Met Val
        1475                1480                1485            
Cys Ala Gly Glu Ser Met Ser Pro Gly Gln Gly Arg Asn Asn Asn Gly
    1490                1495                1500                
Leu Glu Ile Gly Cys Val Val Asp Ala Ala Ser Gly Leu Leu Thr Phe
1505                1510                1515                1520
Ile Ala Asn Gly Lys Glu Leu Ser Thr Tyr Tyr Gln Val Glu Pro Ser
                1525                1530                1535    
Thr Lys Leu Phe Pro Ala Val Phe Ala Gln Ala Thr Ser Pro Asn Val
            1540                1545                1550        
Phe Gln Phe Glu Leu Gly Arg Ile Lys Asn Val Met Pro Leu Ser Ala
        1555                1560                1565            
Gly Leu Phe Lys Ser Glu His Lys Asn Pro Val Pro Gln Cys Pro Pro
    1570                1575                1580                
Arg Leu His Val Gln Phe Leu Ser His Val Leu Trp Ser Arg Met Pro
1585                1590                1595                1600
Asn Gln Phe Leu Lys Val Asp Val Ser Arg Ile Ser Glu Arg Gln Gly
                1605                1610                1615    
Trp Leu Val Gln Cys Leu Asp Pro Leu Gln Phe Met Ser Leu His Ile
            1620                1625                1630        
Pro Glu Glu Asn Arg Ser Val Asp Ile Leu Glu Leu Thr Glu Gln Glu
        1635                1640                1645            
Glu Leu Leu Lys Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val
    1650                1655                1660                
Cys Ala Leu Gly Asn His Arg Val Ala His Ala Leu Cys Ser His Val
1665                1670                1675                1680
Asp Glu Pro Gln Leu Leu Tyr Ala Ile Glu Asn Lys Tyr Met Pro Gly
                1685                1690                1695    
Leu Leu Arg Ala Gly Tyr Tyr Asp Leu Leu Ile Asp Ile His Leu Ser
            1700                1705                1710        
Ser Tyr Ala Thr Ala Arg Leu Met Met Asn Asn Glu Tyr Ile Val Pro
        1715                1720                1725            
Met Thr Glu Glu Thr Lys Ser Ile Thr Leu Phe Pro Asp Glu Asn Lys
    1730                1735                1740                
Lys His Gly Leu Pro Gly Ile Gly Leu Ser Thr Ser Leu Arg Pro Arg
1745                1750                1755                1760
Met Gln Phe Ser Ser Pro Ser Phe Val Ser Ile Ser Asn Glu Cys Tyr
                1765                1770                1775    
Gln Tyr Ser Pro Glu Phe Pro Leu Asp Ile Leu Lys Ser Lys Thr Ile
            1780                1785                1790        
Gln Met Leu Thr Glu Ala Val Lys Glu Gly Ser Leu His Ala Arg Asp
        1795                1800                1805            
Pro Val Gly Gly Thr Thr Glu Phe Leu Phe Val Pro Leu Ile Lys Leu
    1810                1815                1820                
Phe Tyr Thr Leu Leu Ile Met Gly Ile Phe His Asn Glu Asp Leu Lys
1825                1830                1835                1840
His Ile Leu Gln Leu Ile Glu Pro Ser Val Phe Lys Glu Ala Ala Thr
                1845                1850                1855    
Pro Glu Glu Glu Ser Asp Thr Leu Glu Lys Glu Leu Ser Val Asp Asp
            1860                1865                1870        
Ala Lys Leu Gln Gly Ala Gly Glu Glu Glu Ala Lys Gly Gly Lys Arg
        1875                1880                1885            
Pro Lys Glu Gly Leu Leu Gln Met Lys Leu Pro Glu Pro Val Lys Leu
    1890                1895                1900                
Gln Met Cys Leu Leu Leu Gln Tyr Leu Cys Asp Cys Gln Val Arg His
1905                1910                1915                1920
Arg Ile Glu Ala Ile Val Ala Phe Ser Asp Asp Phe Val Ala Lys Leu
                1925                1930                1935    
Gln Asp Asn Gln Arg Phe Arg Tyr Asn Glu Val Met Gln Ala Leu Asn
            1940                1945                1950        
Met Ser Ala Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro
        1955                1960                1965            
Pro Gln Glu Gln Ile Asn Met Leu Leu Asn Phe Lys Asp Asp Lys Ser
    1970                1975                1980                
Glu Cys Pro Cys Pro Glu Glu Ile Arg Asp Gln Leu Leu Asp Phe His
1985                1990                1995                2000
Glu Asp Leu Met Thr His Cys Gly Ile Glu Leu Asp Glu Asp Gly Ser
                2005                2010                2015    
Leu Asp Gly Asn Ser Asp Leu Thr Ile Arg Gly Arg Leu Leu Ser Leu
            2020                2025                2030        
Val Glu Lys Val Thr Tyr Leu Lys Lys Lys Gln Ala Glu Lys Pro Val
        2035                2040                2045            
Glu Ser Asp Ser Lys Lys Ser Ser Thr Leu Gln Gln Leu Ile Ser Glu
    2050                2055                2060                
Thr Met Val Arg Trp Ala Gln Glu Ser Val Ile Glu Asp Pro Glu Leu
2065                2070                2075                2080
Val Arg Ala Met Phe Val Leu Leu His Arg Gln Tyr Asp Gly Ile Gly
                2085                2090                2095    
Gly Leu Val Arg Ala Leu Pro Lys Thr Tyr Thr Ile Asn Gly Val Ser
            2100                2105                2110        
Val Glu Asp Thr Ile Asn Leu Leu Ala Ser Leu Gly Gln Ile Arg Ser
        2115                2120                2125            
Leu Leu Ser Val Arg Met Gly Lys Glu Glu Glu Lys Leu Met Ile Arg
    2130                2135                2140                
Gly Leu Gly Asp Ile Met Asn Asn Lys Val Phe Tyr Gln His Pro Asn
2145                2150                2155                2160
Leu Met Arg Ala Leu Gly Met His Glu Thr Val Met Glu Val Met Val
                2165                2170                2175    
Asn Val Leu Gly Gly Gly Glu Ser Lys Glu Ile Thr Phe Pro Lys Met
            2180                2185                2190        
Val Ala Asn Cys Cys Arg Phe Leu Cys Tyr Phe Cys Arg Ile Ser Arg
        2195                2200                2205            
Gln Asn Gln Lys Ala Met Phe Asp His Leu Ser Tyr Leu Leu Glu Asn
    2210                2215                2220                
Ser Ser Val Gly Leu Ala Ser Pro Ala Met Arg Gly Ser Thr Pro Leu
2225                2230                2235                2240
Asp Val Ala Ala Ala Ser Val Met Asp Asn Asn Glu Leu Ala Leu Ala
                2245                2250                2255    
Leu Arg Glu Pro Asp Leu Glu Lys Val Val Arg Tyr Leu Ala Gly Cys
            2260                2265                2270        
Gly Leu Gln Ser Cys Gln Met Leu Val Ser Lys Gly Tyr Pro Asp Ile
        2275                2280                2285            
Gly Trp Asn Pro Val Glu Gly Glu Arg Tyr Leu Asp Phe Leu Arg Phe
    2290                2295                2300                
Ala Val Phe Cys Asn Gly Glu Ser Val Glu Glu Asn Ala Asn Val Val
2305                2310                2315                2320
Val Arg Leu Leu Ile Arg Arg Pro Glu Cys Phe Gly Pro Ala Leu Arg
                2325                2330                2335    
Gly Glu Gly Gly Asn Gly Leu Leu Ala Ala Met Glu Glu Ala Ile Lys
            2340                2345                2350        
Ile Ala Glu Asp Pro Ser Arg Asp Gly Pro Ser Pro Asn Ser Gly Ser
        2355                2360                2365            
Ser Lys Thr Leu Asp Thr Glu Glu Glu Glu Asp Asp Thr Ile His Met
    2370                2375                2380                
Gly Asn Ala Ile Met Thr Phe Tyr Ser Ala Leu Ile Asp Leu Leu Gly
2385                2390                2395                2400
Arg Cys Ala Pro Glu Met His Leu Ile His Ala Gly Lys Gly Glu Ala
                2405                2410                2415    
Ile Arg Ile Arg Ser Ile Leu Arg Ser Leu Ile Pro Leu Gly Asp Leu
            2420                2425                2430        
Val Gly Val Ile Ser Ile Ala Phe Gln Met Pro Thr Ile Ala Lys Asp
        2435                2440                2445            
Gly Asn Val Val Glu Pro Asp Met Ser Ala Gly Phe Cys Pro Asp His
    2450                2455                2460                
Lys Ala Ala Met Val Leu Phe Leu Asp Arg Val Tyr Gly Ile Glu Val
2465                2470                2475                2480
Gln Asp Phe Leu Leu His Leu Leu Glu Val Gly Phe Leu Pro Asp Leu
                2485                2490                2495    
Arg Ala Ala Ala Ser Leu Asp Thr Ala Ala Leu Ser Ala Thr Asp Met
            2500                2505                2510        
Ala Leu Ala Leu Asn Arg Tyr Leu Cys Thr Ala Val Leu Pro Leu Leu
        2515                2520                2525            
Thr Arg Cys Ala Pro Leu Phe Ala Gly Thr Glu His His Ala Ser Leu
    2530                2535                2540                
Ile Asp Ser Leu Leu His Thr Val Tyr Arg Leu Ser Lys Gly Cys Ser
2545                2550                2555                2560
Leu Thr Lys Ala Gln Arg Asp Ser Ile Glu Val Cys Leu Leu Ser Ile
                2565                2570                2575    
Cys Gly Gln Leu Arg Pro Ser Met Met Gln His Leu Leu Arg Arg Leu
            2580                2585                2590        
Val Phe Asp Val Pro Leu Leu Asn Glu His Ala Lys Met Pro Leu Lys
        2595                2600                2605            
Leu Leu Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr Cys Leu Pro
    2610                2615                2620                
Gly Gly Trp Gly Asn Phe Gly Ala Ala Ser Glu Glu Glu Leu His Leu
2625                2630                2635                2640
Ser Arg Lys Leu Phe Trp Gly Ile Phe Asp Ala Leu Ser Gln Lys Lys
                2645                2650                2655    
Tyr Glu Gln Glu Leu Phe Lys Leu Ala Leu Pro Cys Leu Ser Ala Val
            2660                2665                2670        
Ala Gly Ala Leu Pro Pro Asp Tyr Met Glu Ser Asn Tyr Val Ser Met
        2675                2680                2685            
Met Glu Lys Gln Ser Ser Met Asp Ser Glu Gly Asn Phe Asn Pro Gln
    2690                2695                2700                
Pro Val Asp Thr Ser Asn Ile Thr Ile Pro Glu Lys Leu Glu Tyr Phe
2705                2710                2715                2720
Ile Asn Lys Tyr Ala Glu His Ser His Asp Lys Trp Ser Met Asp Lys
                2725                2730                2735    
Leu Ala Asn Gly Trp Ile Tyr Gly Glu Ile Tyr Ser Asp Ser Ser Lys
            2740                2745                2750        
Val Gln Pro Leu Met Lys Pro Tyr Lys Leu Leu Ser Glu Lys Glu Lys
        2755                2760                2765            
Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Thr Met Leu Ala
    2770                2775                2780                
Arg Thr Met Arg Thr Glu Arg Thr Arg Glu Gly Asp Ser Met Ala Leu
2785                2790                2795                2800
Tyr Asn Arg Thr Arg Arg Ile Ser Gln Thr Ser Gln Val Ser Val Asp
                2805                2810                2815    
Ala Ala His Gly Tyr Ser Pro Arg Ala Ile Asp Met Ser Asn Val Thr
            2820                2825                2830        
Leu Ser Arg Asp Leu His Ala Met Ala Glu Met Met Ala Glu Asn Tyr
        2835                2840                2845            
His Asn Ile Trp Ala Lys Lys Lys Lys Met Glu Leu Glu Ser Lys Gly
    2850                2855                2860                
Gly Gly Asn His Pro Leu Leu Val Pro Tyr Asp Thr Leu Thr Ala Lys
2865                2870                2875                2880
Glu Lys Ala Lys Asp Arg Glu Lys Ala Gln Asp Ile Leu Lys Phe Leu
                2885                2890                2895    
Gln Ile Asn Gly Tyr Ala Val Ser Arg Gly Phe Lys Asp Leu Glu Leu
            2900                2905                2910        
Asp Thr Pro Ser Ile Glu Lys Arg Phe Ala Tyr Ser Phe Leu Gln Gln
        2915                2920                2925            
Leu Ile Arg Tyr Val Asp Glu Ala His Gln Tyr Ile Leu Glu Phe Asp
    2930                2935                2940                
Gly Gly Ser Arg Gly Lys Gly Glu His Phe Pro Tyr Glu Gln Glu Ile
2945                2950                2955                2960
Lys Phe Phe Ala Lys Val Val Leu Pro Leu Ile Asp Gln Tyr Phe Lys
                2965                2970                2975    
Asn His Arg Leu Tyr Phe Leu Ser Ala Ala Ser Arg Pro Leu Cys Ser
            2980                2985                2990        
Gly Gly His Ala Ser Asn Lys Glu Lys Glu Met Val Thr Ser Leu Phe
        2995                3000                3005            
Cys Lys Leu Gly Val Leu Val Arg His Arg Ile Ser Leu Phe Gly Asn
    3010                3015                3020                
Asp Ala Thr Ser Ile Val Asn Cys Leu His Ile Leu Gly Gln Thr Leu
3025                3030                3035                3040
Asp Ala Arg Thr Val Met Lys Thr Gly Leu Glu Ser Val Lys Ser Ala
                3045                3050                3055    
Leu Arg Ala Phe Leu Asp Asn Ala Ala Glu Asp Leu Glu Lys Thr Met
            3060                3065                3070        
Glu Asn Leu Lys Gln Gly Gln Phe Thr His Thr Arg Asn Gln Pro Lys
        3075                3080                3085            
Gly Val Thr Gln Ile Ile Asn Tyr Thr Thr Val Ala Leu Leu Pro Met
    3090                3095                3100                
Leu Ser Ser Leu Phe Glu His Ile Gly Gln His Gln Phe Gly Glu Asp
3105                3110                3115                3120
Leu Ile Leu Glu Asp Val Gln Val Ser Cys Tyr Arg Ile Leu Thr Ser
                3125                3130                3135    
Leu Tyr Ala Leu Gly Thr Ser Lys Ser Ile Tyr Val Glu Arg Gln Arg
            3140                3145                3150        
Ser Ala Leu Gly Glu Cys Leu Ala Ala Phe Ala Gly Ala Phe Pro Val
        3155                3160                3165            
Ala Phe Leu Glu Thr His Leu Asp Lys His Asn Ile Tyr Ser Ile Tyr
    3170                3175                3180                
Asn Thr Lys Ser Ser Arg Glu Arg Ala Ala Leu Ser Leu Pro Thr Asn
3185                3190                3195                3200
Val Glu Asp Val Cys Pro Asn Ile Pro Ser Leu Glu Lys Leu Met Glu
                3205                3210                3215    
Glu Ile Val Glu Leu Ala Glu Ser Gly Ile Arg Tyr Thr Gln Met Pro
            3220                3225                3230        
His Val Met Glu Val Ile Leu Pro Met Leu Cys Ser Tyr Met Ser Arg
        3235                3240                3245            
Trp Trp Glu His Gly Pro Glu Asn Asn Pro Glu Arg Ala Glu Met Cys
    3250                3255                3260                
Cys Thr Ala Leu Asn Ser Glu His Met Asn Thr Leu Leu Gly Asn Ile
3265                3270                3275                3280
Leu Lys Ile Ile Tyr Asn Asn Leu Gly Ile Asp Glu Gly Ala Trp Met
                3285                3290                3295    
Lys Arg Leu Ala Val Phe Ser Gln Pro Ile Ile Asn Lys Val Lys Pro
            3300                3305                3310        
Gln Leu Leu Lys Thr His Phe Leu Pro Leu Met Glu Lys Leu Lys Lys
        3315                3320                3325            
Lys Ala Ala Thr Val Val Ser Glu Glu Asp His Leu Lys Ala Glu Ala
    3330                3335                3340                
Arg Gly Asp Met Ser Glu Ala Glu Leu Leu Ile Leu Asp Glu Phe Thr
3345                3350                3355                3360
Thr Leu Ala Arg Asp Leu Tyr Ala Phe Tyr Pro Leu Leu Ile Arg Phe
                3365                3370                3375    
Val Asp Tyr Asn Arg Ala Lys Trp Leu Lys Glu Pro Asn Pro Glu Ala
            3380                3385                3390        
Glu Glu Leu Phe Arg Met Val Ala Glu Val Phe Ile Tyr Trp Ser Lys
        3395                3400                3405            
Ser His Asn Phe Lys Arg Glu Glu Gln Asn Phe Val Val Gln Asn Glu
    3410                3415                3420                
Ile Asn Asn Met Ser Phe Leu Ile Thr Asp Thr Lys Ser Lys Met Ser
3425                3430                3435                3440
Lys Ala Ala Val Ser Asp Gln Glu Arg Lys Lys Met Lys Arg Lys Gly
                3445                3450                3455    
Asp Arg Tyr Ser Met Gln Thr Ser Leu Ile Val Ala Ala Leu Lys Arg
            3460                3465                3470        
Leu Leu Pro Ile Gly Leu Asn Ile Cys Ala Pro Gly Asp Gln Glu Leu
        3475                3480                3485            
Ile Ala Leu Ala Lys Asn Arg Phe Ser Leu Lys Asp Thr Glu Asp Glu
    3490                3495                3500                
Val Arg Asp Ile Ile Arg Ser Asn Ile His Leu Gln Gly Lys Leu Glu
3505                3510                3515                3520
Asp Pro Ala Ile Arg Trp Gln Met Ala Leu Tyr Lys Asp Leu Pro Asn
                3525                3530                3535    
Arg Thr Asp Asp Thr Ser Asp Pro Glu Lys Thr Val Glu Arg Val Leu
            3540                3545                3550        
Asp Ile Ala Asn Val Leu Phe His Leu Glu Gln Lys Ser Lys Arg Val
        3555                3560                3565            
Gly Arg Arg His Tyr Cys Leu Val Glu His Pro Gln Arg Ser Lys Lys
    3570                3575                3580                
Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Lys Arg Ala Val Val
3585                3590                3595                3600
Ala Cys Phe Arg Met Ala Pro Leu Tyr Asn Leu Pro Arg His Arg Ala
                3605                3610                3615    
Val Asn Leu Phe Leu Gln Gly Tyr Glu Lys Ser Trp Ile Glu Thr Glu
            3620                3625                3630        
Glu His Tyr Phe Glu Asp Lys Leu Ile Glu Asp Leu Ala Lys Pro Gly
        3635                3640                3645            
Ala Glu Pro Pro Glu Glu Asp Glu Gly Thr Lys Arg Val Asp Pro Leu
    3650                3655                3660                
His Gln Leu Ile Leu Leu Phe Ser Arg Thr Ala Leu Thr Glu Lys Cys
3665                3670                3675                3680
Lys Leu Glu Glu Asp Phe Leu Tyr Met Ala Tyr Ala Asp Ile Met Ala
                3685                3690                3695    
Lys Ser Cys His Asp Glu Glu Asp Asp Asp Gly Glu Glu Glu Val Lys
            3700                3705                3710        
Ser Phe Glu Glu Lys Glu Met Glu Lys Gln Lys Leu Leu Tyr Gln Gln
        3715                3720                3725            
Ala Arg Leu His Asp Arg Gly Ala Ala Glu Met Val Leu Gln Thr Ile
    3730                3735                3740                
Ser Ala Ser Lys Gly Glu Thr Gly Pro Met Val Ala Ala Thr Leu Lys
3745                3750                3755                3760
Leu Gly Ile Ala Ile Leu Asn Gly Gly Asn Ser Thr Val Gln Gln Lys
                3765                3770                3775    
Met Leu Asp Tyr Leu Lys Glu Lys Lys Asp Val Gly Phe Phe Gln Ser
            3780                3785                3790        
Leu Ala Gly Leu Met Gln Ser Cys Ser Val Leu Asp Leu Asn Ala Phe
        3795                3800                3805            
Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly Met Val Thr Glu Glu Gly
    3810                3815                3820                
Ser Gly Glu Lys Val Leu Gln Asp Asp Glu Phe Thr Cys Asp Leu Phe
3825                3830                3835                3840
Arg Phe Leu Gln Leu Leu Cys Glu Gly His Asn Ser Asp Phe Gln Asn
                3845                3850                3855    
Tyr Leu Arg Thr Gln Thr Gly Asn Asn Thr Thr Val Asn Ile Ile Ile
            3860                3865                3870        
Ser Thr Val Asp Tyr Leu Leu Arg Val Gln Glu Ser Ile Ser Asp Phe
        3875                3880                3885            
Tyr Trp Tyr Tyr Ser Gly Lys Asp Val Ile Asp Glu Gln Gly Gln Arg
    3890                3895                3900                
Asn Phe Ser Lys Ala Ile Gln Val Ala Lys Gln Val Phe Asn Thr Leu
3905                3910                3915                3920
Thr Glu Tyr Ile Gln Gly Pro Cys Thr Gly Asn Gln Gln Ser Leu Ala
                3925                3930                3935    
His Ser Arg Leu Trp Asp Ala Val Val Gly Phe Leu His Val Phe Ala
            3940                3945                3950        
His Met Gln Met Lys Leu Ser Gln Asp Ser Ser Gln Ile Glu Leu Leu
        3955                3960                3965            
Lys Glu Leu Met Asp Leu Gln Lys Asp Met Val Val Met Leu Leu Ser
    3970                3975                3980                
Met Leu Glu Gly Asn Val Val Asn Gly Thr Ile Gly Lys Gln Met Val
3985                3990                3995                4000
Asp Met Leu Val Glu Ser Ser Asn Asn Val Glu Met Ile Leu Lys Phe
                4005                4010                4015    
Phe Asp Met Phe Leu Lys Leu Lys Asp Leu Thr Ser Ser Asp Thr Phe
            4020                4025                4030        
Lys Glu Tyr Asp Pro Asp Gly Lys Gly Val Ile Ser Lys Arg Asp Phe
        4035                4040                4045            
His Lys Ala Met Glu Ser His Lys His Tyr Thr Gln Ser Glu Thr Glu
    4050                4055                4060                
Phe Leu Leu Ser Cys Ala Glu Thr Asp Glu Asn Glu Thr Leu Asp Tyr
4065                4070                4075                4080
Glu Glu Phe Val Lys Arg Phe His Glu Pro Ala Lys Asp Ile Gly Phe
                4085                4090                4095    
Asn Val Ala Val Leu Leu Thr Asn Leu Ser Glu His Met Pro Asn Asp
            4100                4105                4110        
Thr Arg Leu Gln Thr Phe Leu Glu Leu Ala Glu Ser Val Leu Asn Tyr
        4115                4120                4125            
Phe Gln Pro Phe Leu Gly Arg Ile Glu Ile Met Gly Ser Ala Lys Arg
    4130                4135                4140                
Ile Glu Arg Val Tyr Phe Glu Ile Ser Glu Ser Ser Arg Thr Gln Trp
4145                4150                4155                4160
Glu Lys Pro Gln Val Lys Glu Ser Lys Arg Gln Phe Ile Phe Asp Val
                4165                4170                4175    
Val Asn Glu Gly Gly Glu Lys Glu Lys Met Glu Leu Phe Val Asn Phe
            4180                4185                4190        
Cys Glu Asp Thr Ile Phe Glu Met Gln Leu Ala Ala Gln Ile Ser Glu
        4195                4200                4205            
Ser Asp Leu Asn Glu Arg Ser Ala Asn Lys Glu Glu Ser Glu Lys Glu
    4210                4215                4220                
Arg Pro Glu Glu Gln Gly Pro Arg Met Ala Phe Phe Ser Ile Leu Thr
4225                4230                4235                4240
Val Arg Ser Ala Leu Phe Ala Leu Arg Tyr Asn Ile Leu Thr Leu Met
                4245                4250                4255    
Arg Met Leu Ser Leu Lys Ser Leu Lys Lys Gln Met Lys Lys Val Lys
            4260                4265                4270        
Lys Met Thr Val Lys Asp Met Val Thr Ala Phe Phe Ser Ser Tyr Trp
        4275                4280                4285            
Ser Ile Phe Met Thr Leu Leu His Phe Val Ala Ser Val Phe Arg Gly
    4290                4295                4300                
Phe Phe Arg Ile Ile Cys Ser Leu Leu Leu Gly Gly Ser Leu Val Glu
4305                4310                4315                4320
Gly Ala Lys Lys Ile Lys Val Ala Glu Leu Leu Ala Asn Met Pro Asp
                4325                4330                4335    
Pro Thr Gln Asp Glu Val Arg Gly Asp Gly Glu Glu Gly Glu Arg Lys
            4340                4345                4350        
Pro Leu Glu Ala Ala Leu Pro Ser Glu Asp Leu Thr Asp Leu Lys Glu
        4355                4360                4365            
Leu Thr Glu Glu Ser Asp Leu Leu Ser Asp Ile Phe Gly Leu Asp Leu
    4370                4375                4380                
Lys Arg Glu Gly Gly Gln Tyr Lys Leu Ile Pro His Asn Pro Asn Ala
4385                4390                4395                4400
Gly Leu Ser Asp Leu Met Ser Asn Pro Val Pro Met Pro Glu Val Gln
                4405                4410                4415    
Glu Lys Phe Gln Glu Gln Lys Ala Lys Glu Glu Glu Lys Glu Glu Lys
            4420                4425                4430        
Glu Glu Thr Lys Ser Glu Pro Glu Lys Ala Glu Gly Glu Asp Gly Glu
        4435                4440                4445            
Lys Glu Glu Lys Ala Lys Glu Asp Lys Gly Lys Gln Lys Leu Arg Gln
    4450                4455                4460                
Leu His Thr His Arg Tyr Gly Glu Pro Glu Val Pro Glu Ser Ala Phe
4465                4470                4475                4480
Trp Lys Lys Ile Ile Ala Tyr Gln Gln Lys Leu Leu Asn Tyr Phe Ala
                4485                4490                4495    
Arg Asn Phe Tyr Asn Met Arg Met Leu Ala Leu Phe Val Ala Phe Ala
            4500                4505                4510        
Ile Asn Phe Ile Leu Leu Phe Tyr Lys Val Ser Thr Ser Ser Val Val
        4515                4520                4525            
Glu Gly Lys Glu Leu Pro Thr Arg Ser Ser Ser Glu Asn Ala Lys Val
    4530                4535                4540                
Thr Ser Leu Asp Ser Ser Ser His Arg Ile Ile Ala Val His Tyr Val
4545                4550                4555                4560
Leu Glu Glu Ser Ser Gly Tyr Met Glu Pro Thr Leu Arg Ile Leu Ala
                4565                4570                4575    
Ile Leu His Thr Val Ile Ser Phe Phe Cys Ile Ile Gly Tyr Tyr Cys
            4580                4585                4590        
Leu Lys Val Pro Leu Val Ile Phe Lys Arg Glu Lys Glu Val Ala Arg
        4595                4600                4605            
Lys Leu Glu Phe Asp Gly Leu Tyr Ile Thr Glu Gln Pro Ser Glu Asp
    4610                4615                4620                
Asp Ile Lys Gly Gln Trp Asp Arg Leu Val Ile Asn Thr Gln Ser Phe
4625                4630                4635                4640
Pro Asn Asn Tyr Trp Asp Lys Phe Val Lys Arg Lys Val Met Asp Lys
                4645                4650                4655    
Tyr Gly Glu Phe Tyr Gly Arg Asp Arg Ile Ser Glu Leu Leu Gly Met
            4660                4665                4670        
Asp Lys Ala Ala Leu Asp Phe Ser Asp Ala Arg Glu Lys Lys Lys Pro
        4675                4680                4685            
Lys Lys Asp Ser Ser Leu Ser Ala Val Leu Asn Ser Ile Asp Val Lys
    4690                4695                4700                
Tyr Gln Met Trp Lys Leu Gly Val Val Phe Thr Asp Asn Ser Phe Leu
4705                4710                4715                4720
Tyr Leu Ala Trp Tyr Met Thr Met Ser Val Leu Gly His Tyr Asn Asn
                4725                4730                4735    
Phe Phe Phe Ala Ala His Leu Leu Asp Ile Ala Met Gly Phe Lys Thr
            4740                4745                4750        
Leu Arg Thr Ile Leu Ser Ser Val Thr His Asn Gly Lys Gln Leu Val
        4755                4760                4765            
Leu Thr Val Gly Leu Leu Ala Val Val Val Tyr Leu Tyr Thr Val Val
    4770                4775                4780                
Ala Phe Asn Phe Phe Arg Lys Phe Tyr Asn Lys Ser Glu Asp Gly Asp
4785                4790                4795                4800
Thr Pro Asp Met Lys Cys Asp Asp Met Leu Thr Cys Tyr Met Phe His
                4805                4810                4815    
Met Tyr Val Gly Val Arg Ala Gly Gly Gly Ile Gly Asp Glu Ile Glu
            4820                4825                4830        
Asp Pro Ala Gly Asp Glu Tyr Glu Ile Tyr Arg Ile Ile Phe Asp Ile
        4835                4840                4845            
Thr Phe Phe Phe Phe Val Ile Val Ile Leu Leu Ala Ile Ile Gln Gly
    4850                4855                4860                
Leu Ile Ile Asp Ala Phe Gly Glu Leu Arg Asp Gln Gln Glu Gln Val
4865                4870                4875                4880
Lys Glu Asp Met Glu Thr Lys Cys Phe Ile Cys Gly Ile Gly Asn Asp
                4885                4890                4895    
Tyr Phe Asp Thr Val Pro His Gly Phe Glu Thr His Thr Leu Gln Glu
            4900                4905                4910        
His Asn Leu Ala Asn Tyr Leu Phe Phe Leu Met Tyr Leu Ile Asn Lys
        4915                4920                4925            
Asp Glu Thr Glu His Thr Gly Gln Glu Ser Tyr Val Trp Lys Met Tyr
    4930                4935                4940                
Gln Glu Arg Cys Trp Glu Phe Phe Pro Ala Gly Asp Cys Phe Arg Lys
4945                4950                4955                4960
Gln Tyr Glu Asp Gln Leu Asn
                4965        


<210> 9349
<211> 4975
<212> PRT
<213> Homo sapiens

<400> 9349
Met Ala Asp Gly Gly Glu Gly Glu Asp Glu Ile Gln Phe Leu Arg Thr
 1               5                  10                  15      
Asp Asp Glu Val Val Leu Gln Cys Thr Ala Thr Ile His Lys Glu Gln
            20                  25                  30          
Gln Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe
        35                  40                  45              
Leu Glu Ser Thr Ser Asn Ser Lys Asn Val Pro Pro Asp Leu Ser Ile
    50                  55                  60                  
Cys Thr Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu
65                  70                  75                  80  
Met Leu Ala Asn Thr Val Glu Lys Ser Glu Gly Gln Val Asp Val Glu
                85                  90                  95      
Lys Trp Lys Phe Met Met Lys Thr Ala Gln Gly Gly Gly His Arg Thr
            100                 105                 110         
Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ser Tyr Ser Gly Met
        115                 120                 125             
Tyr Leu Cys Cys Leu Ser Thr Ser Arg Ser Ser Thr Asp Lys Leu Ala
    130                 135                 140                 
Phe Asp Val Gly Leu Gln Glu Asp Thr Thr Gly Glu Ala Cys Trp Trp
145                 150                 155                 160 
Thr Ile His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu Lys Val Arg
                165                 170                 175     
Val Gly Asp Asp Leu Ile Leu Val Ser Val Ser Ser Glu Arg Tyr Leu
            180                 185                 190         
His Leu Ser Tyr Gly Asn Gly Ser Leu His Val Asp Ala Ala Phe Gln
        195                 200                 205             
Gln Thr Leu Trp Ser Val Ala Pro Ile Ser Ser Gly Ser Glu Ala Ala
    210                 215                 220                 
Gln Gly Tyr Leu Ile Gly Gly Asp Val Leu Arg Leu Leu His Gly His
225                 230                 235                 240 
Met Asp Glu Cys Leu Thr Val Pro Ser Gly Glu His Gly Glu Glu Gln
                245                 250                 255     
Arg Arg Thr Val His Tyr Glu Gly Gly Ala Val Ser Val His Ala Arg
            260                 265                 270         
Ser Leu Trp Arg Leu Glu Thr Leu Arg Val Ala Trp Ser Gly Ser His
        275                 280                 285             
Ile Arg Trp Gly Gln Pro Phe Arg Leu Arg His Val Thr Thr Gly Lys
    290                 295                 300                 
Tyr Leu Ser Leu Met Glu Asp Lys Asn Leu Leu Leu Met Asp Lys Glu
305                 310                 315                 320 
Lys Ala Asp Val Lys Ser Thr Ala Phe Thr Phe Arg Ser Ser Lys Glu
                325                 330                 335     
Lys Leu Asp Val Gly Val Arg Lys Glu Val Asp Gly Met Gly Thr Ser
            340                 345                 350         
Glu Ile Lys Tyr Gly Asp Ser Val Cys Tyr Ile Gln His Val Asp Thr
        355                 360                 365             
Gly Leu Trp Leu Thr Tyr Gln Ser Val Asp Val Lys Ser Val Arg Met
    370                 375                 380                 
Gly Ser Ile Gln Arg Lys Ala Ile Met His His Glu Gly His Met Asp
385                 390                 395                 400 
Asp Gly Ile Ser Leu Ser Arg Ser Gln His Glu Glu Ser Arg Thr Ala
                405                 410                 415     
Arg Val Ile Arg Ser Thr Val Phe Leu Phe Asn Arg Phe Ile Arg Gly
            420                 425                 430         
Leu Asp Ala Leu Ser Lys Lys Ala Lys Ala Ser Thr Val Asp Leu Pro
        435                 440                 445             
Ile Glu Ser Val Ser Leu Ser Leu Gln Asp Leu Ile Gly Tyr Phe His
    450                 455                 460                 
Pro Pro Asp Glu His Leu Glu His Glu Asp Lys Gln Asn Arg Leu Arg
465                 470                 475                 480 
Ala Leu Lys Asn Arg Gln Asn Leu Phe Gln Glu Glu Gly Met Ile Asn
                485                 490                 495     
Leu Val Leu Glu Cys Ile Asp Arg Leu His Val Tyr Ser Ser Ala Ala
            500                 505                 510         
His Phe Ala Asp Val Ala Gly Arg Glu Ala Gly Glu Ser Trp Lys Ser
        515                 520                 525             
Ile Leu Asn Ser Leu Tyr Glu Leu Leu Ala Ala Leu Ile Arg Gly Asn
    530                 535                 540                 
Arg Lys Asn Cys Ala Gln Phe Ser Gly Ser Leu Asp Trp Leu Ile Ser
545                 550                 555                 560 
Arg Leu Glu Arg Leu Glu Ala Ser Ser Gly Ile Leu Glu Val Leu His
                565                 570                 575     
Cys Val Leu Val Glu Ser Pro Glu Ala Leu Asn Ile Ile Lys Glu Gly
            580                 585                 590         
His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly Arg Asn His
        595                 600                 605             
Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys His Gly Val Ala
    610                 615                 620                 
Val Arg Ser Asn Gln His Leu Ile Cys Asp Asn Leu Leu Pro Gly Arg
625                 630                 635                 640 
Asp Leu Leu Leu Gln Thr Arg Leu Val Asn His Val Ser Ser Met Arg
                645                 650                 655     
Pro Asn Ile Phe Leu Gly Val Ser Glu Gly Ser Ala Gln Tyr Lys Lys
            660                 665                 670         
Trp Tyr Tyr Glu Leu Met Val Asp His Thr Glu Pro Phe Val Thr Ala
        675                 680                 685             
Glu Ala Thr His Leu Arg Val Gly Trp Ala Ser Thr Glu Gly Tyr Ser
    690                 695                 700                 
Pro Tyr Pro Gly Gly Gly Glu Glu Trp Gly Gly Asn Gly Val Gly Asp
705                 710                 715                 720 
Asp Leu Phe Ser Tyr Gly Phe Asp Gly Leu His Leu Trp Ser Gly Cys
                725                 730                 735     
Ile Ala Arg Thr Val Ser Ser Pro Asn Gln His Leu Leu Arg Thr Asp
            740                 745                 750         
Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Ala Pro Ser Ile Ser Phe
        755                 760                 765             
Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn Phe Asn Ile
    770                 775                 780                 
Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala Gly Ile Lys Val
785                 790                 795                 800 
Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys Phe Leu Pro Pro
                805                 810                 815     
Pro Gly Tyr Ala Pro Cys Tyr Glu Ala Val Leu Pro Lys Glu Lys Leu
            820                 825                 830         
Lys Val Glu His Ser Arg Glu Tyr Lys Gln Glu Arg Thr Tyr Thr Arg
        835                 840                 845             
Asp Leu Leu Gly Pro Thr Val Ser Leu Thr Gln Ala Ala Phe Thr Pro
    850                 855                 860                 
Ile Pro Val Asp Thr Ser Gln Ile Val Leu Pro Pro His Leu Glu Arg
865                 870                 875                 880 
Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu Trp Val Met Asn
                885                 890                 895     
Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg Asp Asp Asn Lys
            900                 905                 910         
Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro Glu Gln Glu
        915                 920                 925             
Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu Lys Thr Leu Leu
    930                 935                 940                 
Ala Leu Gly Cys His Val Gly Ile Ser Asp Glu His Ala Glu Asp Lys
945                 950                 955                 960 
Val Lys Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu Thr Ser Gly Tyr
                965                 970                 975     
Lys Pro Ala Pro Met Asp Leu Ser Phe Ile Lys Leu Thr Pro Ser Gln
            980                 985                 990         
Glu Ala Met Val Asp Lys Leu Ala Glu Asn Ala His Asn Val Trp Ala
        995                 1000                1005            
Arg Asp Arg Ile Arg Gln Gly Trp Thr Tyr Gly Ile Gln Gln Asp Val
    1010                1015                1020                
Lys Asn Arg Arg Asn Pro Arg Leu Val Pro Tyr Thr Pro Leu Asp Asp
1025                1030                1035                1040
Arg Thr Lys Lys Ser Asn Lys Asp Ser Leu Arg Glu Ala Val Arg Thr
                1045                1050                1055    
Leu Leu Gly Tyr Gly Tyr Asn Leu Glu Ala Pro Asp Gln Asp His Ala
            1060                1065                1070        
Ala Arg Ala Glu Val Cys Ser Gly Thr Gly Glu Arg Phe Arg Ile Phe
        1075                1080                1085            
Arg Ala Glu Lys Thr Tyr Ala Val Lys Ala Gly Arg Trp Tyr Phe Glu
    1090                1095                1100                
Phe Glu Thr Val Thr Ala Gly Asp Met Arg Val Gly Trp Ser Arg Pro
1105                1110                1115                1120
Gly Cys Gln Pro Asp Gln Glu Leu Gly Ser Asp Glu Arg Ala Phe Ala
                1125                1130                1135    
Phe Asp Gly Phe Lys Ala Gln Arg Trp His Gln Gly Asn Glu His Tyr
            1140                1145                1150        
Gly Arg Ser Trp Gln Ala Gly Asp Val Val Gly Cys Met Val Asp Met
        1155                1160                1165            
Asn Glu His Thr Met Met Phe Thr Leu Asn Gly Glu Ile Leu Leu Asp
    1170                1175                1180                
Asp Ser Gly Ser Glu Leu Ala Phe Lys Asp Phe Asp Val Gly Asp Gly
1185                1190                1195                1200
Phe Ile Pro Val Cys Ser Leu Gly Val Ala Gln Val Gly Arg Met Asn
                1205                1210                1215    
Phe Gly Lys Asp Val Ser Thr Leu Lys Tyr Phe Thr Ile Cys Gly Leu
            1220                1225                1230        
Gln Glu Gly Tyr Glu Pro Phe Ala Val Asn Thr Asn Arg Asp Ile Thr
        1235                1240                1245            
Met Trp Leu Ser Lys Arg Leu Pro Gln Phe Leu Gln Val Pro Ser Asn
    1250                1255                1260                
His Glu His Ile Glu Val Thr Arg Ile Asp Gly Thr Ile Asp Ser Ser
1265                1270                1275                1280
Pro Cys Leu Lys Val Thr Gln Lys Ser Phe Gly Ser Gln Asn Ser Asn
                1285                1290                1295    
Thr Asp Ile Met Phe Tyr Arg Leu Ser Met Pro Ile Glu Cys Ala Glu
            1300                1305                1310        
Val Phe Ser Lys Thr Val Ala Gly Gly Leu Pro Gly Ala Gly Leu Phe
        1315                1320                1325            
Gly Pro Lys Asn Asp Leu Glu Asp Tyr Asp Ala Asp Ser Asp Phe Glu
    1330                1335                1340                
Val Leu Met Lys Thr Ala His Gly His Leu Val Pro Asp Arg Val Asp
1345                1350                1355                1360
Lys Asp Lys Glu Ala Thr Lys Pro Glu Phe Asn Asn His Lys Asp Tyr
                1365                1370                1375    
Ala Gln Glu Lys Pro Ser Arg Leu Lys Gln Arg Phe Leu Leu Arg Arg
            1380                1385                1390        
Thr Lys Pro Asp Tyr Ser Thr Ser His Ser Ala Arg Leu Thr Glu Asp
        1395                1400                1405            
Val Leu Ala Asp Asp Arg Asp Asp Tyr Asp Phe Leu Met Gln Thr Ser
    1410                1415                1420                
Thr Tyr Tyr Tyr Ser Val Arg Ile Phe Pro Gly Gln Glu Pro Ala Asn
1425                1430                1435                1440
Val Trp Val Gly Trp Ile Thr Ser Asp Phe His Gln Tyr Asp Thr Gly
                1445                1450                1455    
Phe Asp Leu Asp Arg Val Arg Thr Val Thr Val Thr Leu Gly Asp Glu
            1460                1465                1470        
Lys Gly Lys Val His Glu Ser Ile Lys Arg Ser Asn Cys Tyr Met Val
        1475                1480                1485            
Cys Ala Gly Glu Ser Met Ser Pro Gly Gln Gly Arg Asn Asn Asn Gly
    1490                1495                1500                
Leu Glu Ile Gly Cys Val Val Asp Ala Ala Ser Gly Leu Leu Thr Phe
1505                1510                1515                1520
Ile Ala Asn Gly Lys Glu Leu Ser Thr Tyr Tyr Gln Val Glu Pro Ser
                1525                1530                1535    
Thr Lys Leu Phe Pro Ala Val Phe Ala Gln Ala Thr Ser Pro Asn Val
            1540                1545                1550        
Phe Gln Phe Glu Leu Gly Arg Ile Lys Asn Val Met Pro Leu Ser Ala
        1555                1560                1565            
Gly Leu Phe Lys Ser Glu His Lys Asn Pro Val Pro Gln Cys Pro Pro
    1570                1575                1580                
Arg Leu His Val Gln Phe Leu Ser His Val Leu Trp Ser Arg Met Pro
1585                1590                1595                1600
Asn Gln Phe Leu Lys Val Asp Val Ser Arg Ile Ser Glu Arg Gln Gly
                1605                1610                1615    
Trp Leu Val Gln Cys Leu Asp Pro Leu Gln Phe Met Ser Leu His Ile
            1620                1625                1630        
Pro Glu Glu Asn Arg Ser Val Asp Ile Leu Glu Leu Thr Glu Gln Glu
        1635                1640                1645            
Glu Leu Leu Lys Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val
    1650                1655                1660                
Cys Ala Leu Gly Asn His Arg Val Ala His Ala Leu Cys Ser His Val
1665                1670                1675                1680
Asp Glu Pro Gln Leu Leu Tyr Ala Ile Glu Asn Lys Tyr Met Pro Gly
                1685                1690                1695    
Leu Leu Arg Ala Gly Tyr Tyr Asp Leu Leu Ile Asp Ile His Leu Ser
            1700                1705                1710        
Ser Tyr Ala Thr Ala Arg Leu Met Met Asn Asn Glu Tyr Ile Val Pro
        1715                1720                1725            
Met Thr Glu Glu Thr Lys Ser Ile Thr Leu Phe Pro Asp Glu Asn Lys
    1730                1735                1740                
Lys His Gly Leu Pro Gly Ile Gly Leu Ser Thr Ser Leu Arg Pro Arg
1745                1750                1755                1760
Met Gln Phe Ser Ser Pro Ser Phe Val Ser Ile Ser Asn Glu Cys Tyr
                1765                1770                1775    
Gln Tyr Ser Pro Glu Phe Pro Leu Asp Ile Leu Lys Ser Lys Thr Ile
            1780                1785                1790        
Gln Met Leu Thr Glu Ala Val Lys Glu Gly Ser Leu His Ala Arg Asp
        1795                1800                1805            
Pro Val Gly Gly Thr Thr Glu Phe Leu Phe Val Pro Leu Ile Lys Leu
    1810                1815                1820                
Phe Tyr Thr Leu Leu Ile Met Gly Ile Phe His Asn Glu Asp Leu Lys
1825                1830                1835                1840
His Ile Leu Gln Leu Ile Glu Pro Ser Val Phe Lys Glu Ala Ala Thr
                1845                1850                1855    
Pro Glu Glu Glu Ser Asp Thr Leu Glu Lys Glu Leu Ser Val Asp Asp
            1860                1865                1870        
Ala Lys Leu Gln Gly Ala Gly Glu Glu Glu Ala Lys Gly Gly Lys Arg
        1875                1880                1885            
Pro Lys Glu Gly Leu Leu Gln Met Lys Leu Pro Glu Pro Val Lys Leu
    1890                1895                1900                
Gln Met Cys Leu Leu Leu Gln Tyr Leu Cys Asp Cys Gln Val Arg His
1905                1910                1915                1920
Arg Ile Glu Ala Ile Val Ala Phe Ser Asp Asp Phe Val Ala Lys Leu
                1925                1930                1935    
Gln Asp Asn Gln Arg Phe Arg Tyr Asn Glu Val Met Gln Ala Leu Asn
            1940                1945                1950        
Met Ser Ala Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro
        1955                1960                1965            
Pro Gln Glu Gln Ile Asn Met Leu Leu Asn Phe Lys Asp Asp Lys Ser
    1970                1975                1980                
Glu Cys Pro Cys Pro Glu Glu Ile Arg Asp Gln Leu Leu Asp Phe His
1985                1990                1995                2000
Glu Asp Leu Met Thr His Cys Gly Ile Glu Leu Asp Glu Asp Gly Ser
                2005                2010                2015    
Leu Asp Gly Asn Ser Asp Leu Thr Ile Arg Gly Arg Leu Leu Ser Leu
            2020                2025                2030        
Val Glu Lys Val Thr Tyr Leu Lys Lys Lys Gln Ala Glu Lys Pro Val
        2035                2040                2045            
Glu Ser Asp Ser Lys Lys Ser Ser Thr Leu Gln Gln Leu Ile Ser Glu
    2050                2055                2060                
Thr Met Val Arg Trp Ala Gln Glu Ser Val Ile Glu Asp Pro Glu Leu
2065                2070                2075                2080
Val Arg Ala Met Phe Val Leu Leu His Arg Gln Tyr Asp Gly Ile Gly
                2085                2090                2095    
Gly Leu Val Arg Ala Leu Pro Lys Thr Tyr Thr Ile Asn Gly Val Ser
            2100                2105                2110        
Val Glu Asp Thr Ile Asn Leu Leu Ala Ser Leu Gly Gln Ile Arg Ser
        2115                2120                2125            
Leu Leu Ser Val Arg Met Gly Lys Glu Glu Glu Lys Leu Met Ile Arg
    2130                2135                2140                
Gly Leu Gly Asp Ile Met Asn Asn Lys Val Phe Tyr Gln His Pro Asn
2145                2150                2155                2160
Leu Met Arg Ala Leu Gly Met His Glu Thr Val Met Glu Val Met Val
                2165                2170                2175    
Asn Val Leu Gly Gly Gly Glu Ser Lys Glu Ile Thr Phe Pro Lys Met
            2180                2185                2190        
Val Ala Asn Cys Cys Arg Phe Leu Cys Tyr Phe Cys Arg Ile Ser Arg
        2195                2200                2205            
Gln Asn Gln Lys Ala Met Phe Asp His Leu Ser Tyr Leu Leu Glu Asn
    2210                2215                2220                
Ser Ser Val Gly Leu Ala Ser Pro Ala Met Arg Gly Ser Thr Pro Leu
2225                2230                2235                2240
Asp Val Ala Ala Ala Ser Val Met Asp Asn Asn Glu Leu Ala Leu Ala
                2245                2250                2255    
Leu Arg Glu Pro Asp Leu Glu Lys Val Val Arg Tyr Leu Ala Gly Cys
            2260                2265                2270        
Gly Leu Gln Ser Cys Gln Met Leu Val Ser Lys Gly Tyr Pro Asp Ile
        2275                2280                2285            
Gly Trp Asn Pro Val Glu Gly Glu Arg Tyr Leu Asp Phe Leu Arg Phe
    2290                2295                2300                
Ala Val Phe Cys Asn Gly Glu Ser Val Glu Glu Asn Ala Asn Val Val
2305                2310                2315                2320
Val Arg Leu Leu Ile Arg Arg Pro Glu Cys Phe Gly Pro Ala Leu Arg
                2325                2330                2335    
Gly Glu Gly Gly Asn Gly Leu Leu Ala Ala Met Glu Glu Ala Ile Lys
            2340                2345                2350        
Ile Ala Glu Asp Pro Ser Arg Asp Gly Pro Ser Pro Asn Ser Gly Ser
        2355                2360                2365            
Ser Lys Thr Leu Asp Thr Glu Glu Glu Glu Asp Asp Thr Ile His Met
    2370                2375                2380                
Gly Asn Ala Ile Met Thr Phe Tyr Ser Ala Leu Ile Asp Leu Leu Gly
2385                2390                2395                2400
Arg Cys Ala Pro Glu Met His Leu Ile His Ala Gly Lys Gly Glu Ala
                2405                2410                2415    
Ile Arg Ile Arg Ser Ile Leu Arg Ser Leu Ile Pro Leu Gly Asp Leu
            2420                2425                2430        
Val Gly Val Ile Ser Ile Ala Phe Gln Met Pro Thr Ile Ala Lys Asp
        2435                2440                2445            
Gly Asn Val Val Glu Pro Asp Met Ser Ala Gly Phe Cys Pro Asp His
    2450                2455                2460                
Lys Ala Ala Met Val Leu Phe Leu Asp Arg Val Tyr Gly Ile Glu Val
2465                2470                2475                2480
Gln Asp Phe Leu Leu His Leu Leu Glu Val Gly Phe Leu Pro Asp Leu
                2485                2490                2495    
Arg Ala Ala Ala Ser Leu Asp Thr Ala Ala Leu Ser Ala Thr Asp Met
            2500                2505                2510        
Ala Leu Ala Leu Asn Arg Tyr Leu Cys Thr Ala Val Leu Pro Leu Leu
        2515                2520                2525            
Thr Arg Cys Ala Pro Leu Phe Ala Gly Thr Glu His His Ala Ser Leu
    2530                2535                2540                
Ile Asp Ser Leu Leu His Thr Val Tyr Arg Leu Ser Lys Gly Cys Ser
2545                2550                2555                2560
Leu Thr Lys Ala Gln Arg Asp Ser Ile Glu Val Cys Leu Leu Ser Ile
                2565                2570                2575    
Cys Gly Gln Leu Arg Pro Ser Met Met Gln His Leu Leu Arg Arg Leu
            2580                2585                2590        
Val Phe Asp Val Pro Leu Leu Asn Glu His Ala Lys Met Pro Leu Lys
        2595                2600                2605            
Leu Leu Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr Cys Leu Pro
    2610                2615                2620                
Gly Gly Trp Gly Asn Phe Gly Ala Ala Ser Glu Glu Glu Leu His Leu
2625                2630                2635                2640
Ser Arg Lys Leu Phe Trp Gly Ile Phe Asp Ala Leu Ser Gln Lys Lys
                2645                2650                2655    
Tyr Glu Gln Glu Leu Phe Lys Leu Ala Leu Pro Cys Leu Ser Ala Val
            2660                2665                2670        
Ala Gly Ala Leu Pro Pro Asp Tyr Met Glu Ser Asn Tyr Val Ser Met
        2675                2680                2685            
Met Glu Lys Gln Ser Ser Met Asp Ser Glu Gly Asn Phe Asn Pro Gln
    2690                2695                2700                
Pro Val Asp Thr Ser Asn Ile Thr Ile Pro Glu Lys Leu Glu Tyr Phe
2705                2710                2715                2720
Ile Asn Lys Tyr Ala Glu His Ser His Asp Lys Trp Ser Met Asp Lys
                2725                2730                2735    
Leu Ala Asn Gly Trp Ile Tyr Gly Glu Ile Tyr Ser Asp Ser Ser Lys
            2740                2745                2750        
Val Gln Pro Leu Met Lys Pro Tyr Lys Leu Leu Ser Glu Lys Glu Lys
        2755                2760                2765            
Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Thr Met Leu Ala
    2770                2775                2780                
Arg Thr Met Arg Thr Glu Arg Thr Arg Glu Gly Asp Ser Met Ala Leu
2785                2790                2795                2800
Tyr Asn Arg Thr Arg Arg Ile Ser Gln Thr Ser Gln Val Ser Val Asp
                2805                2810                2815    
Ala Ala His Gly Tyr Ser Pro Arg Ala Ile Asp Met Ser Asn Val Thr
            2820                2825                2830        
Leu Ser Arg Asp Leu His Ala Met Ala Glu Met Met Ala Glu Asn Tyr
        2835                2840                2845            
His Asn Ile Trp Ala Lys Lys Lys Lys Met Glu Leu Glu Ser Lys Gly
    2850                2855                2860                
Gly Gly Asn His Pro Leu Leu Val Pro Tyr Asp Thr Leu Thr Ala Lys
2865                2870                2875                2880
Glu Lys Ala Lys Asp Arg Glu Lys Ala Gln Asp Ile Leu Lys Phe Leu
                2885                2890                2895    
Gln Ile Asn Gly Tyr Ala Val Ser Arg Gly Phe Lys Asp Leu Glu Leu
            2900                2905                2910        
Asp Thr Pro Ser Ile Glu Lys Arg Phe Ala Tyr Ser Phe Leu Gln Gln
        2915                2920                2925            
Leu Ile Arg Tyr Val Asp Glu Ala His Gln Tyr Ile Leu Glu Phe Asp
    2930                2935                2940                
Gly Gly Ser Arg Gly Lys Gly Glu His Phe Pro Tyr Glu Gln Glu Ile
2945                2950                2955                2960
Lys Phe Phe Ala Lys Val Val Leu Pro Leu Ile Asp Gln Tyr Phe Lys
                2965                2970                2975    
Asn His Arg Leu Tyr Phe Leu Ser Ala Ala Ser Arg Pro Leu Cys Ser
            2980                2985                2990        
Gly Gly His Ala Ser Asn Lys Glu Lys Glu Met Val Thr Ser Leu Phe
        2995                3000                3005            
Cys Lys Leu Gly Val Leu Val Arg His Arg Ile Ser Leu Phe Gly Asn
    3010                3015                3020                
Asp Ala Thr Ser Ile Val Asn Cys Leu His Ile Leu Gly Gln Thr Leu
3025                3030                3035                3040
Asp Ala Arg Thr Val Met Lys Thr Gly Leu Glu Ser Val Lys Ser Ala
                3045                3050                3055    
Leu Arg Ala Phe Leu Asp Asn Ala Ala Glu Asp Leu Glu Lys Thr Met
            3060                3065                3070        
Glu Asn Leu Lys Gln Gly Gln Phe Thr His Thr Arg Asn Gln Pro Lys
        3075                3080                3085            
Gly Val Thr Gln Ile Ile Asn Tyr Thr Thr Val Ala Leu Leu Pro Met
    3090                3095                3100                
Leu Ser Ser Leu Phe Glu His Ile Gly Gln His Gln Phe Gly Glu Asp
3105                3110                3115                3120
Leu Ile Leu Glu Asp Val Gln Val Ser Cys Tyr Arg Ile Leu Thr Ser
                3125                3130                3135    
Leu Tyr Ala Leu Gly Thr Ser Lys Ser Ile Tyr Val Glu Arg Gln Arg
            3140                3145                3150        
Ser Ala Leu Gly Glu Cys Leu Ala Ala Phe Ala Gly Ala Phe Pro Val
        3155                3160                3165            
Ala Phe Leu Glu Thr His Leu Asp Lys His Asn Ile Tyr Ser Ile Tyr
    3170                3175                3180                
Asn Thr Lys Ser Ser Arg Glu Arg Ala Ala Leu Ser Leu Pro Thr Asn
3185                3190                3195                3200
Val Glu Asp Val Cys Pro Asn Ile Pro Ser Leu Glu Lys Leu Met Glu
                3205                3210                3215    
Glu Ile Val Glu Leu Ala Glu Ser Gly Ile Arg Tyr Thr Gln Met Pro
            3220                3225                3230        
His Val Met Glu Val Ile Leu Pro Met Leu Cys Ser Tyr Met Ser Arg
        3235                3240                3245            
Trp Trp Glu His Gly Pro Glu Asn Asn Pro Glu Arg Ala Glu Met Cys
    3250                3255                3260                
Cys Thr Ala Leu Asn Ser Glu His Met Asn Thr Leu Leu Gly Asn Ile
3265                3270                3275                3280
Leu Lys Ile Ile Tyr Asn Asn Leu Gly Ile Asp Glu Gly Ala Trp Met
                3285                3290                3295    
Lys Arg Leu Ala Val Phe Ser Gln Pro Ile Ile Asn Lys Val Lys Pro
            3300                3305                3310        
Gln Leu Leu Lys Thr His Phe Leu Pro Leu Met Glu Lys Leu Lys Lys
        3315                3320                3325            
Lys Ala Ala Thr Val Val Ser Glu Glu Asp His Leu Lys Ala Glu Ala
    3330                3335                3340                
Arg Gly Asp Met Ser Glu Ala Glu Leu Leu Ile Leu Asp Glu Phe Thr
3345                3350                3355                3360
Thr Leu Ala Arg Asp Leu Tyr Ala Phe Tyr Pro Leu Leu Ile Arg Phe
                3365                3370                3375    
Val Asp Tyr Asn Arg Ala Lys Trp Leu Lys Glu Pro Asn Pro Glu Ala
            3380                3385                3390        
Glu Glu Leu Phe Arg Met Val Ala Glu Val Phe Ile Tyr Trp Ser Lys
        3395                3400                3405            
Ser His Asn Phe Lys Arg Glu Glu Gln Asn Phe Val Val Gln Asn Glu
    3410                3415                3420                
Ile Asn Asn Met Ser Phe Leu Ile Thr Asp Thr Lys Ser Lys Met Ser
3425                3430                3435                3440
Lys Ala Ala Val Ser Asp Gln Glu Arg Lys Lys Met Lys Arg Lys Gly
                3445                3450                3455    
Asp Arg Tyr Ser Met Gln Thr Ser Leu Ile Val Ala Ala Leu Lys Arg
            3460                3465                3470        
Leu Leu Pro Ile Gly Leu Asn Ile Cys Ala Pro Gly Asp Gln Glu Leu
        3475                3480                3485            
Ile Ala Leu Ala Lys Asn Arg Phe Ser Leu Lys Asp Thr Glu Asp Glu
    3490                3495                3500                
Val Arg Asp Ile Ile Arg Ser Asn Ile His Leu Gln Gly Lys Leu Glu
3505                3510                3515                3520
Asp Pro Ala Ile Arg Trp Gln Met Ala Leu Tyr Lys Asp Leu Pro Asn
                3525                3530                3535    
Arg Thr Asp Asp Thr Ser Asp Pro Glu Lys Thr Val Glu Arg Val Leu
            3540                3545                3550        
Asp Ile Ala Asn Val Leu Phe His Leu Glu Gln Lys Ser Lys Arg Val
        3555                3560                3565            
Gly Arg Arg His Tyr Cys Leu Val Glu His Pro Gln Arg Ser Lys Lys
    3570                3575                3580                
Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Lys Arg Ala Val Val
3585                3590                3595                3600
Ala Cys Phe Arg Met Ala Pro Leu Tyr Asn Leu Pro Arg His Arg Ala
                3605                3610                3615    
Val Asn Leu Phe Leu Gln Gly Tyr Glu Lys Ser Trp Ile Glu Thr Glu
            3620                3625                3630        
Glu His Tyr Phe Glu Asp Lys Leu Ile Glu Asp Leu Ala Lys Pro Gly
        3635                3640                3645            
Ala Glu Pro Pro Glu Glu Asp Glu Gly Thr Lys Arg Val Asp Pro Leu
    3650                3655                3660                
His Gln Leu Ile Leu Leu Phe Ser Arg Thr Ala Leu Thr Glu Lys Cys
3665                3670                3675                3680
Lys Leu Glu Glu Asp Phe Leu Tyr Met Ala Tyr Ala Asp Ile Met Ala
                3685                3690                3695    
Lys Ser Cys His Asp Glu Glu Asp Asp Asp Gly Glu Glu Glu Val Lys
            3700                3705                3710        
Ser Phe Glu Val Thr Gly Ser Gln Arg Ser Lys Glu Lys Glu Met Glu
        3715                3720                3725            
Lys Gln Lys Leu Leu Tyr Gln Gln Ala Arg Leu His Asp Arg Gly Ala
    3730                3735                3740                
Ala Glu Met Val Leu Gln Thr Ile Ser Ala Ser Lys Gly Glu Thr Gly
3745                3750                3755                3760
Pro Met Val Ala Ala Thr Leu Lys Leu Gly Ile Ala Ile Leu Asn Gly
                3765                3770                3775    
Gly Asn Ser Thr Val Gln Gln Lys Met Leu Asp Tyr Leu Lys Glu Lys
            3780                3785                3790        
Lys Asp Val Gly Phe Phe Gln Ser Leu Ala Gly Leu Met Gln Ser Cys
        3795                3800                3805            
Ser Val Leu Asp Leu Asn Ala Phe Glu Arg Gln Asn Lys Ala Glu Gly
    3810                3815                3820                
Leu Gly Met Val Thr Glu Glu Gly Ser Gly Glu Lys Val Leu Gln Asp
3825                3830                3835                3840
Asp Glu Phe Thr Cys Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu
                3845                3850                3855    
Gly His Asn Ser Asp Phe Gln Asn Tyr Leu Arg Thr Gln Thr Gly Asn
            3860                3865                3870        
Asn Thr Thr Val Asn Ile Ile Ile Ser Thr Val Asp Tyr Leu Leu Arg
        3875                3880                3885            
Val Gln Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp
    3890                3895                3900                
Val Ile Asp Glu Gln Gly Gln Arg Asn Phe Ser Lys Ala Ile Gln Val
3905                3910                3915                3920
Ala Lys Gln Val Phe Asn Thr Leu Thr Glu Tyr Ile Gln Gly Pro Cys
                3925                3930                3935    
Thr Gly Asn Gln Gln Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val
            3940                3945                3950        
Val Gly Phe Leu His Val Phe Ala His Met Gln Met Lys Leu Ser Gln
        3955                3960                3965            
Asp Ser Ser Gln Ile Glu Leu Leu Lys Glu Leu Met Asp Leu Gln Lys
    3970                3975                3980                
Asp Met Val Val Met Leu Leu Ser Met Leu Glu Gly Asn Val Val Asn
3985                3990                3995                4000
Gly Thr Ile Gly Lys Gln Met Val Asp Met Leu Val Glu Ser Ser Asn
                4005                4010                4015    
Asn Val Glu Met Ile Leu Lys Phe Phe Asp Met Phe Leu Lys Leu Lys
            4020                4025                4030        
Asp Leu Thr Ser Ser Asp Thr Phe Lys Glu Tyr Asp Pro Asp Gly Lys
        4035                4040                4045            
Gly Val Ile Ser Lys Arg Asp Phe His Lys Ala Met Glu Ser His Lys
    4050                4055                4060                
His Tyr Thr Gln Ser Glu Thr Glu Phe Leu Leu Ser Cys Ala Glu Thr
4065                4070                4075                4080
Asp Glu Asn Glu Thr Leu Asp Tyr Glu Glu Phe Val Lys Arg Phe His
                4085                4090                4095    
Glu Pro Ala Lys Asp Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn
            4100                4105                4110        
Leu Ser Glu His Met Pro Asn Asp Thr Arg Leu Gln Thr Phe Leu Glu
        4115                4120                4125            
Leu Ala Glu Ser Val Leu Asn Tyr Phe Gln Pro Phe Leu Gly Arg Ile
    4130                4135                4140                
Glu Ile Met Gly Ser Ala Lys Arg Ile Glu Arg Val Tyr Phe Glu Ile
4145                4150                4155                4160
Ser Glu Ser Ser Arg Thr Gln Trp Glu Lys Pro Gln Val Lys Glu Ser
                4165                4170                4175    
Lys Arg Gln Phe Ile Phe Asp Val Val Asn Glu Gly Gly Glu Lys Glu
            4180                4185                4190        
Lys Met Glu Leu Phe Val Asn Phe Cys Glu Asp Thr Ile Phe Glu Met
        4195                4200                4205            
Gln Leu Ala Ala Gln Ile Ser Glu Ser Asp Leu Asn Glu Arg Ser Ala
    4210                4215                4220                
Asn Lys Glu Glu Ser Glu Lys Glu Arg Pro Glu Glu Gln Gly Pro Arg
4225                4230                4235                4240
Met Ala Phe Phe Ser Ile Leu Thr Val Arg Ser Ala Leu Phe Ala Leu
                4245                4250                4255    
Arg Tyr Asn Ile Leu Thr Leu Met Arg Met Leu Ser Leu Lys Ser Leu
            4260                4265                4270        
Lys Lys Gln Met Lys Lys Val Lys Lys Met Thr Val Lys Asp Met Val
        4275                4280                4285            
Thr Ala Phe Phe Ser Ser Tyr Trp Ser Ile Phe Met Thr Leu Leu His
    4290                4295                4300                
Phe Val Ala Ser Val Phe Arg Gly Phe Phe Arg Ile Ile Cys Ser Leu
4305                4310                4315                4320
Leu Leu Gly Gly Ser Leu Val Glu Gly Ala Lys Lys Ile Lys Val Ala
                4325                4330                4335    
Glu Leu Leu Ala Asn Met Pro Asp Pro Thr Gln Asp Glu Val Arg Gly
            4340                4345                4350        
Asp Gly Glu Glu Gly Glu Arg Lys Pro Leu Glu Ala Ala Leu Pro Ser
        4355                4360                4365            
Glu Asp Leu Thr Asp Leu Lys Glu Leu Thr Glu Glu Ser Asp Leu Leu
    4370                4375                4380                
Ser Asp Ile Phe Gly Leu Asp Leu Lys Arg Glu Gly Gly Gln Tyr Lys
4385                4390                4395                4400
Leu Ile Pro His Asn Pro Asn Ala Gly Leu Ser Asp Leu Met Ser Asn
                4405                4410                4415    
Pro Val Pro Met Pro Glu Val Gln Glu Lys Phe Gln Glu Gln Lys Ala
            4420                4425                4430        
Lys Glu Glu Glu Lys Glu Glu Lys Glu Glu Thr Lys Ser Glu Pro Glu
        4435                4440                4445            
Lys Ala Glu Gly Glu Asp Gly Glu Lys Glu Glu Lys Ala Lys Glu Asp
    4450                4455                4460                
Lys Gly Lys Gln Lys Leu Arg Gln Leu His Thr His Arg Tyr Gly Glu
4465                4470                4475                4480
Pro Glu Val Pro Glu Ser Ala Phe Trp Lys Lys Ile Ile Ala Tyr Gln
                4485                4490                4495    
Gln Lys Leu Leu Asn Tyr Phe Ala Arg Asn Phe Tyr Asn Met Arg Met
            4500                4505                4510        
Leu Ala Leu Phe Val Ala Phe Ala Ile Asn Phe Ile Leu Leu Phe Tyr
        4515                4520                4525            
Lys Val Ser Thr Ser Ser Val Val Glu Gly Lys Glu Leu Pro Thr Arg
    4530                4535                4540                
Ser Ser Ser Glu Asn Ala Lys Val Thr Ser Leu Asp Ser Ser Ser His
4545                4550                4555                4560
Arg Ile Ile Ala Val His Tyr Val Leu Glu Glu Ser Ser Gly Tyr Met
                4565                4570                4575    
Glu Pro Thr Leu Arg Ile Leu Ala Ile Leu His Thr Val Ile Ser Phe
            4580                4585                4590        
Phe Cys Ile Ile Gly Tyr Tyr Cys Leu Lys Val Pro Leu Val Ile Phe
        4595                4600                4605            
Lys Arg Glu Lys Glu Val Ala Arg Lys Leu Glu Phe Asp Gly Leu Tyr
    4610                4615                4620                
Ile Thr Glu Gln Pro Ser Glu Asp Asp Ile Lys Gly Gln Trp Asp Arg
4625                4630                4635                4640
Leu Val Ile Asn Thr Gln Ser Phe Pro Asn Asn Tyr Trp Asp Lys Phe
                4645                4650                4655    
Val Lys Arg Lys Val Met Asp Lys Tyr Gly Glu Phe Tyr Gly Arg Asp
            4660                4665                4670        
Arg Ile Ser Glu Leu Leu Gly Met Asp Lys Ala Ala Leu Asp Phe Ser
        4675                4680                4685            
Asp Ala Arg Glu Lys Lys Lys Pro Lys Lys Asp Ser Ser Leu Ser Ala
    4690                4695                4700                
Val Leu Asn Ser Ile Asp Val Lys Tyr Gln Met Trp Lys Leu Gly Val
4705                4710                4715                4720
Val Phe Thr Asp Asn Ser Phe Leu Tyr Leu Ala Trp Tyr Met Thr Met
                4725                4730                4735    
Ser Val Leu Gly His Tyr Asn Asn Phe Phe Phe Ala Ala His Leu Leu
            4740                4745                4750        
Asp Ile Ala Met Gly Phe Lys Thr Leu Arg Thr Ile Leu Ser Ser Val
        4755                4760                4765            
Thr His Asn Gly Lys Gln Leu Val Leu Thr Val Gly Leu Leu Ala Val
    4770                4775                4780                
Val Val Tyr Leu Tyr Thr Val Val Ala Phe Asn Phe Phe Arg Lys Phe
4785                4790                4795                4800
Tyr Asn Lys Ser Glu Asp Gly Asp Thr Pro Asp Met Lys Cys Asp Asp
                4805                4810                4815    
Met Leu Thr Cys Tyr Met Phe His Met Tyr Val Gly Val Arg Ala Gly
            4820                4825                4830        
Gly Gly Ile Gly Asp Glu Ile Glu Asp Pro Ala Gly Asp Glu Tyr Glu
        4835                4840                4845            
Ile Tyr Arg Ile Ile Phe Asp Ile Thr Phe Phe Phe Phe Val Ile Val
    4850                4855                4860                
Ile Leu Leu Ala Ile Ile Gln Gly Leu Ile Ile Asp Ala Phe Gly Glu
4865                4870                4875                4880
Leu Arg Asp Gln Gln Glu Gln Val Lys Glu Asp Met Glu Thr Lys Cys
                4885                4890                4895    
Phe Ile Cys Gly Ile Gly Asn Asp Tyr Phe Asp Thr Val Pro His Gly
            4900                4905                4910        
Phe Glu Thr His Thr Leu Gln Glu His Asn Leu Ala Asn Tyr Leu Phe
        4915                4920                4925            
Phe Leu Met Tyr Leu Ile Asn Lys Asp Glu Thr Glu His Thr Gly Gln
    4930                4935                4940                
Glu Ser Tyr Val Trp Lys Met Tyr Gln Glu Arg Cys Trp Glu Phe Phe
4945                4950                4955                4960
Pro Ala Gly Asp Cys Phe Arg Lys Gln Tyr Glu Asp Gln Leu Asn
                4965                4970                4975


<210> 9350
<211> 562
<212> PRT
<213> Homo sapiens

<400> 9350
Met Thr Arg Asn Ala Arg Pro Asn Ile Val Leu Leu Met Ala Asp Asp
 1               5                  10                  15      
Leu Gly Val Gly Asp Leu Cys Cys Tyr Gly Asn Asn Ser Val Ser Thr
            20                  25                  30          
Pro Asn Ile Asp Arg Leu Ala Ser Glu Gly Val Arg Leu Thr Gln His
        35                  40                  45              
Leu Ala Ala Ala Ser Met Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr
    50                  55                  60                  
Gly Arg Tyr Pro Ile Arg Ser Gly Met Val Ser Ala Tyr Asn Leu Asn
65                  70                  75                  80  
Arg Ala Phe Thr Trp Leu Gly Gly Ser Gly Gly Leu Pro Thr Asn Glu
                85                  90                  95      
Thr Thr Phe Ala Lys Leu Leu Gln His Arg Gly Tyr Arg Thr Gly Leu
            100                 105                 110         
Ile Gly Lys Trp His Leu Gly Leu Ser Cys Ala Ser Arg Asn Asp His
        115                 120                 125             
Cys Tyr His Pro Leu Asn His Gly Phe His Tyr Phe Tyr Gly Val Pro
    130                 135                 140                 
Phe Gly Leu Leu Ser Asp Cys Gln Ala Ser Lys Thr Pro Glu Leu His
145                 150                 155                 160 
Arg Trp Leu Arg Ile Lys Leu Trp Ile Ser Thr Val Ala Leu Ala Leu
                165                 170                 175     
Val Pro Phe Leu Leu Leu Ile Pro Lys Phe Ala Arg Trp Phe Ser Val
            180                 185                 190         
Pro Trp Lys Val Ile Phe Val Phe Ala Leu Leu Ala Phe Leu Phe Phe
        195                 200                 205             
Thr Ser Trp Tyr Ser Ser Tyr Gly Phe Thr Arg Arg Trp Asn Cys Ile
    210                 215                 220                 
Leu Met Arg Asn His Glu Ile Ile Gln Gln Pro Met Lys Glu Glu Lys
225                 230                 235                 240 
Val Ala Ser Leu Met Leu Lys Glu Ala Leu Ala Phe Ile Glu Arg Tyr
                245                 250                 255     
Lys Arg Glu Pro Phe Leu Leu Phe Phe Ser Phe Leu His Val His Thr
            260                 265                 270         
Pro Leu Ile Ser Lys Lys Lys Phe Val Gly Arg Ser Lys Tyr Gly Arg
        275                 280                 285             
Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Met Val Gly Lys Ile Leu
    290                 295                 300                 
Asp Ala Leu Asp Gln Glu Arg Leu Ala Asn His Thr Leu Val Tyr Phe
305                 310                 315                 320 
Thr Ser Asp Asn Gly Gly His Leu Glu Pro Leu Asp Gly Ala Val Gln
                325                 330                 335     
Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly Gly
            340                 345                 350         
Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe Arg Trp Pro Ser Val
        355                 360                 365             
Leu Glu Ala Gly Arg Val Ile Asn Glu Pro Thr Ser Leu Met Asp Ile
    370                 375                 380                 
Tyr Pro Thr Leu Ser Tyr Ile Gly Gly Gly Ile Leu Ser Gln Asp Arg
385                 390                 395                 400 
Val Ile Asp Gly Gln Asn Leu Met Pro Leu Leu Glu Gly Arg Ala Ser
                405                 410                 415     
His Ser Asp His Glu Phe Leu Phe His Tyr Cys Gly Val Tyr Leu His
            420                 425                 430         
Thr Val Arg Trp His Gln Lys Asp Cys Ala Thr Val Trp Lys Ala His
        435                 440                 445             
Tyr Val Thr Pro Lys Phe Tyr Pro Glu Gly Thr Gly Ala Cys Tyr Gly
    450                 455                 460                 
Ser Gly Ile Cys Ser Cys Ser Gly Asp Val Thr Tyr His Asp Pro Pro
465                 470                 475                 480 
Leu Leu Phe Asp Ile Ser Arg Asp Pro Ser Glu Ala Leu Pro Leu Asn
                485                 490                 495     
Pro Asp Asn Glu Pro Leu Phe Asp Ser Val Ile Lys Lys Met Glu Ala
            500                 505                 510         
Ala Ile Arg Glu His Arg Arg Thr Leu Thr Pro Val Pro Gln Gln Phe
        515                 520                 525             
Ser Val Phe Asn Thr Ile Trp Lys Pro Trp Leu Gln Pro Cys Cys Gly
    530                 535                 540                 
Thr Phe Pro Phe Cys Gly Cys Asp Lys Glu Asp Asp Ile Leu Pro Met
545                 550                 555                 560 
Ala Pro
        


<210> 9351
<211> 1689
<212> PRT
<213> Homo sapiens

<400> 9351
Met Leu Ala Ser Pro Glu Pro Lys Gly Leu Val Pro Phe Thr Lys Glu
 1               5                  10                  15      
Ser Phe Glu Leu Ile Lys Gln His Ile Ala Lys Thr His Asn Glu Asp
            20                  25                  30          
His Glu Glu Glu Asp Leu Lys Pro Thr Pro Asp Leu Glu Val Gly Lys
        35                  40                  45              
Lys Leu Pro Phe Ile Tyr Gly Asn Leu Ser Gln Gly Met Val Ser Glu
    50                  55                  60                  
Pro Leu Glu Asp Val Asp Pro Tyr Tyr Tyr Lys Lys Lys Asn Thr Phe
65                  70                  75                  80  
Ile Val Leu Asn Lys Asn Arg Thr Ile Phe Arg Phe Asn Ala Ala Ser
                85                  90                  95      
Ile Leu Cys Thr Leu Ser Pro Phe Asn Cys Ile Arg Arg Thr Thr Ile
            100                 105                 110         
Lys Val Leu Val His Pro Tyr Pro Phe Leu Leu Thr Ser Thr Phe Phe
        115                 120                 125             
Gln Leu Phe Ile Leu Ile Ser Val Leu Ile Asp Cys Val Phe Met Ser
    130                 135                 140                 
Leu Thr Asn Leu Pro Lys Trp Arg Pro Val Leu Glu Asn Thr Leu Leu
145                 150                 155                 160 
Gly Ile Tyr Thr Phe Glu Ile Leu Val Lys Leu Phe Ala Arg Gly Val
                165                 170                 175     
Trp Ala Gly Ser Phe Ser Phe Leu Gly Asp Pro Trp Asn Trp Leu Asp
            180                 185                 190         
Phe Ser Val Thr Val Phe Glu Val Ile Ile Arg Tyr Ser Pro Leu Asp
        195                 200                 205             
Phe Ile Pro Thr Leu Gln Thr Ala Arg Thr Leu Arg Ile Leu Lys Ile
    210                 215                 220                 
Ile Pro Leu Asn Gln Gly Leu Lys Ser Leu Val Gly Val Leu Ile His
225                 230                 235                 240 
Cys Leu Lys Gln Leu Ile Gly Val Ile Ile Leu Thr Leu Phe Phe Leu
                245                 250                 255     
Ser Ile Phe Ser Leu Ile Gly Met Gly Leu Phe Met Gly Asn Leu Lys
            260                 265                 270         
His Lys Cys Phe Arg Trp Pro Gln Glu Asn Glu Asn Glu Thr Leu His
        275                 280                 285             
Asn Arg Thr Gly Asn Pro Tyr Tyr Ile Arg Glu Thr Glu Asn Phe Tyr
    290                 295                 300                 
Tyr Leu Glu Gly Glu Arg Tyr Ala Leu Leu Cys Gly Asn Arg Thr Asp
305                 310                 315                 320 
Ala Gly Gln Cys Pro Glu Gly Tyr Val Cys Val Lys Ala Gly Ile Asn
                325                 330                 335     
Pro Asp Gln Gly Phe Thr Asn Phe Asp Ser Phe Gly Trp Ala Leu Phe
            340                 345                 350         
Ala Leu Phe Arg Leu Met Ala Gln Asp Tyr Pro Glu Val Leu Tyr His
        355                 360                 365             
Gln Ile Leu Tyr Ala Ser Gly Lys Val Tyr Met Ile Phe Phe Val Val
    370                 375                 380                 
Val Ser Phe Leu Phe Ser Phe Tyr Met Ala Ser Leu Phe Leu Gly Ile
385                 390                 395                 400 
Leu Ala Met Ala Tyr Glu Glu Glu Lys Gln Arg Val Gly Glu Ile Ser
                405                 410                 415     
Lys Lys Ile Glu Pro Lys Phe Gln Gln Thr Gly Lys Glu Leu Gln Glu
            420                 425                 430         
Gly Asn Glu Thr Asp Glu Ala Lys Thr Ile Gln Ile Glu Met Lys Lys
        435                 440                 445             
Arg Ser Pro Ile Ser Thr Asp Thr Ser Leu Asp Val Leu Glu Asp Ala
    450                 455                 460                 
Thr Leu Arg His Lys Glu Glu Leu Glu Lys Ser Lys Lys Ile Cys Pro
465                 470                 475                 480 
Leu Tyr Trp Tyr Lys Phe Ala Lys Thr Phe Leu Ile Trp Asn Cys Ser
                485                 490                 495     
Pro Cys Trp Leu Lys Leu Lys Glu Phe Val His Arg Ile Ile Met Ala
            500                 505                 510         
Pro Phe Thr Asp Leu Phe Leu Ile Ile Cys Ile Ile Leu Asn Val Cys
        515                 520                 525             
Phe Leu Thr Leu Glu His Tyr Pro Met Ser Lys Gln Thr Asn Thr Leu
    530                 535                 540                 
Leu Asn Ile Gly Asn Leu Val Phe Ile Gly Ile Phe Thr Ala Glu Met
545                 550                 555                 560 
Ile Phe Lys Ile Ile Ala Met His Pro Tyr Gly Tyr Phe Gln Val Gly
                565                 570                 575     
Trp Asn Ile Phe Asp Ser Met Ile Val Phe His Gly Leu Ile Glu Leu
            580                 585                 590         
Cys Leu Ala Asn Val Ala Gly Met Ala Leu Leu Arg Leu Phe Arg Met
        595                 600                 605             
Leu Arg Ile Phe Lys Leu Gly Lys Tyr Trp Pro Thr Phe Gln Ile Leu
    610                 615                 620                 
Met Trp Ser Leu Ser Asn Ser Trp Val Ala Leu Lys Asp Leu Val Leu
625                 630                 635                 640 
Leu Leu Phe Thr Phe Ile Phe Phe Ser Ala Ala Phe Gly Met Lys Leu
                645                 650                 655     
Phe Gly Lys Asn Tyr Glu Glu Phe Val Cys His Ile Asp Lys Asp Cys
            660                 665                 670         
Gln Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Asn
        675                 680                 685             
Val Phe Arg Ile Leu Cys Gly Glu Trp Val Glu Thr Leu Trp Asp Cys
    690                 695                 700                 
Met Glu Val Ala Gly Gln Ser Trp Cys Ile Pro Phe Tyr Leu Met Val
705                 710                 715                 720 
Ile Leu Ile Gly Asn Leu Leu Val Leu Tyr Leu Phe Leu Ala Leu Val
                725                 730                 735     
Ser Ser Phe Ser Ser Cys Lys Asp Val Thr Ala Glu Glu Asn Asn Glu
            740                 745                 750         
Ala Lys Asn Leu Gln Leu Ala Val Ala Arg Ile Lys Lys Gly Ile Asn
        755                 760                 765             
Tyr Val Leu Leu Lys Ile Leu Cys Lys Thr Gln Asn Val Pro Lys Asp
    770                 775                 780                 
Thr Met Asp His Val Asn Glu Val Tyr Val Lys Glu Asp Ile Ser Asp
785                 790                 795                 800 
His Thr Leu Ser Glu Leu Ser Asn Thr Gln Asp Phe Leu Lys Asp Lys
                805                 810                 815     
Glu Lys Ser Ser Gly Thr Glu Lys Asn Ala Thr Glu Asn Glu Ser Gln
            820                 825                 830         
Ser Leu Ile Pro Ser Pro Ser Val Ser Glu Thr Val Pro Ile Ala Ser
        835                 840                 845             
Gly Glu Ser Asp Ile Glu Asn Leu Asp Asn Lys Glu Ile Gln Ser Lys
    850                 855                 860                 
Ser Gly Asp Gly Gly Ser Lys Glu Lys Ile Lys Gln Ser Ser Ser Ser
865                 870                 875                 880 
Glu Cys Ser Thr Val Asp Ile Ala Ile Ser Glu Glu Glu Glu Met Phe
                885                 890                 895     
Tyr Gly Gly Glu Arg Ser Lys His Leu Lys Asn Gly Cys Arg Arg Gly
            900                 905                 910         
Ser Ser Leu Gly Gln Ile Ser Gly Ala Ser Lys Lys Gly Lys Ile Trp
        915                 920                 925             
Gln Asn Ile Arg Lys Thr Cys Cys Lys Ile Val Glu Asn Asn Trp Phe
    930                 935                 940                 
Lys Cys Phe Ile Gly Leu Val Thr Leu Leu Ser Thr Gly Thr Leu Ala
945                 950                 955                 960 
Phe Glu Asp Ile Tyr Met Asp Gln Arg Lys Thr Ile Lys Ile Leu Leu
                965                 970                 975     
Glu Tyr Ala Asp Met Ile Phe Thr Tyr Ile Phe Ile Leu Glu Met Leu
            980                 985                 990         
Leu Lys Trp Met Ala Tyr Gly Phe Lys Ala Tyr Phe Ser Asn Gly Trp
        995                 1000                1005            
Tyr Arg Leu Asp Phe Val Val Val Ile Val Phe Cys Leu Ser Leu Ile
    1010                1015                1020                
Gly Lys Thr Arg Glu Glu Leu Lys Pro Leu Ile Ser Met Lys Phe Leu
1025                1030                1035                1040
Arg Pro Leu Arg Val Leu Ser Gln Phe Glu Arg Met Lys Val Val Val
                1045                1050                1055    
Arg Ala Leu Ile Lys Thr Thr Leu Pro Thr Leu Asn Val Phe Leu Val
            1060                1065                1070        
Cys Leu Met Ile Trp Leu Ile Phe Ser Ile Met Gly Val Asp Leu Phe
        1075                1080                1085            
Ala Gly Arg Phe Tyr Glu Cys Ile Asp Pro Thr Ser Gly Glu Arg Phe
    1090                1095                1100                
Pro Ser Ser Glu Val Met Asn Lys Ser Arg Cys Glu Ser Leu Leu Phe
1105                1110                1115                1120
Asn Glu Ser Met Leu Trp Glu Asn Ala Lys Met Asn Phe Asp Asn Val
                1125                1130                1135    
Gly Asn Gly Phe Leu Ser Leu Leu Gln Val Ala Thr Phe Asn Gly Trp
            1140                1145                1150        
Ile Thr Ile Met Asn Ser Ala Ile Asp Ser Val Ala Val Asn Ile Gln
        1155                1160                1165            
Pro His Phe Glu Val Asn Ile Tyr Met Tyr Cys Tyr Phe Ile Asn Phe
    1170                1175                1180                
Ile Ile Phe Gly Val Phe Leu Pro Leu Ser Met Leu Ile Thr Val Ile
1185                1190                1195                1200
Ile Asp Asn Phe Asn Lys His Lys Ile Lys Ile Ser Ser Asn Ile Phe
                1205                1210                1215    
Ile Thr Val Lys Gln Arg Lys Gln Tyr Arg Arg Leu Lys Lys Leu Met
            1220                1225                1230        
Tyr Glu Asp Ser Gln Arg Pro Val Pro Arg Pro Leu Asn Lys Leu Gln
        1235                1240                1245            
Gly Phe Ile Phe Asp Val Val Thr Ser Gln Ala Phe Asn Val Ile Val
    1250                1255                1260                
Met Val Leu Ile Cys Phe Gln Ala Ile Ala Met Met Ile Asp Thr Asp
1265                1270                1275                1280
Val Gln Ser Leu Gln Met Ser Ile Ala Leu Tyr Trp Ile Asn Ser Ile
                1285                1290                1295    
Phe Val Met Leu Tyr Thr Met Glu Cys Ile Leu Lys Leu Ile Ala Phe
            1300                1305                1310        
Arg Cys Phe Tyr Phe Thr Ile Ala Trp Asn Ile Phe Asp Phe Met Val
        1315                1320                1325            
Val Ile Phe Ser Ile Thr Gly Leu Cys Leu Pro Met Thr Val Gly Ser
    1330                1335                1340                
Tyr Leu Val Pro Pro Ser Leu Val Gln Leu Ile Leu Leu Ser Arg Ile
1345                1350                1355                1360
Ile His Met Leu Arg Leu Gly Lys Gly Pro Lys Val Phe His Asn Leu
                1365                1370                1375    
Met Leu Pro Leu Met Leu Ser Leu Pro Ala Leu Leu Asn Ile Ile Leu
            1380                1385                1390        
Leu Ile Phe Leu Val Met Phe Ile Tyr Ala Val Phe Gly Met Tyr Asn
        1395                1400                1405            
Phe Ala Tyr Val Lys Lys Glu Ala Gly Ile Asn Asp Val Ser Asn Phe
    1410                1415                1420                
Glu Thr Phe Gly Asn Ser Met Leu Cys Leu Phe Gln Val Ala Ile Phe
1425                1430                1435                1440
Ala Gly Trp Asp Gly Met Leu Asp Ala Ile Phe Asn Ser Lys Trp Ser
                1445                1450                1455    
Asp Cys Asp Pro Asp Lys Ile Asn Pro Gly Thr Gln Val Arg Gly Asp
            1460                1465                1470        
Cys Gly Asn Pro Ser Val Gly Ile Phe Tyr Phe Val Ser Tyr Ile Leu
        1475                1480                1485            
Ile Ser Trp Leu Ile Ile Val Asn Met Tyr Ile Val Val Val Met Glu
    1490                1495                1500                
Phe Leu Asn Ile Ala Ser Lys Lys Lys Asn Lys Thr Leu Ser Glu Asp
1505                1510                1515                1520
Asp Phe Arg Lys Phe Phe Gln Val Trp Lys Arg Phe Asp Pro Asp Arg
                1525                1530                1535    
Thr Gln Tyr Ile Asp Ser Ser Lys Leu Ser Asp Phe Ala Ala Ala Leu
            1540                1545                1550        
Asp Pro Pro Leu Phe Met Ala Lys Pro Asn Lys Gly Gln Leu Ile Ala
        1555                1560                1565            
Leu Asp Leu Pro Met Ala Val Gly Asp Arg Ile His Cys Leu Asp Ile
    1570                1575                1580                
Leu Leu Ala Phe Thr Lys Arg Val Met Gly Gln Asp Val Arg Met Glu
1585                1590                1595                1600
Lys Val Val Ser Glu Ile Glu Ser Gly Phe Leu Leu Ala Asn Pro Phe
                1605                1610                1615    
Lys Ile Thr Cys Glu Pro Ile Thr Thr Thr Leu Lys Arg Lys Gln Glu
            1620                1625                1630        
Ala Val Ser Ala Thr Ile Ile Gln Arg Ala Tyr Lys Asn Tyr Arg Leu
        1635                1640                1645            
Arg Arg Asn Asp Lys Asn Thr Ser Asp Ile His Met Ile Asp Gly Asp
    1650                1655                1660                
Arg Asp Val His Ala Thr Lys Glu Gly Ala Tyr Phe Asp Lys Ala Lys
1665                1670                1675                1680
Glu Lys Ser Pro Ile Gln Ser Gln Ile
                1685                


<210> 9352
<211> 1948
<212> PRT
<213> Homo sapiens

<400> 9352
Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met
 1               5                  10                  15      
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro
            20                  25                  30          
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly
        35                  40                  45              
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val
    50                  55                  60                  
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr
65                  70                  75                  80  
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu
                85                  90                  95      
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser
            100                 105                 110         
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp
        115                 120                 125             
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys
    130                 135                 140                 
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly
145                 150                 155                 160 
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp
                165                 170                 175     
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe
            180                 185                 190         
Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu
        195                 200                 205             
Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val
    210                 215                 220                 
Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu Val
225                 230                 235                 240 
Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile
                245                 250                 255     
Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro
            260                 265                 270         
Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu
        275                 280                 285             
Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys
    290                 295                 300                 
Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile
305                 310                 315                 320 
Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly
                325                 330                 335     
Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp
            340                 345                 350         
Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys
        355                 360                 365             
Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr
    370                 375                 380                 
Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile
385                 390                 395                 400 
Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser
                405                 410                 415     
Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn
            420                 425                 430         
Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu
        435                 440                 445             
Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr
    450                 455                 460                 
Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val
465                 470                 475                 480 
Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr
                485                 490                 495     
Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu
            500                 505                 510         
Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro
        515                 520                 525             
Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser
    530                 535                 540                 
Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe
545                 550                 555                 560 
Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr
                565                 570                 575     
Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe
            580                 585                 590         
Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val
        595                 600                 605             
Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp
    610                 615                 620                 
Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val Ser Trp Arg
625                 630                 635                 640 
Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly Tyr Ser Val
                645                 650                 655     
Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys Glu Val Asn
            660                 665                 670         
Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala Leu Glu Lys
        675                 680                 685             
Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu Val Gly Pro
    690                 695                 700                 
Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu Asp Val Pro
705                 710                 715                 720 
Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala
                725                 730                 735     
Ile Arg Val Leu Trp Leu Gly Pro Val Pro Gly Arg Gln His Gly Gln
            740                 745                 750         
Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly Ala Glu Gly
        755                 760                 765             
Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp Ala Gln Trp
    770                 775                 780                 
Glu Thr Asp Asp Thr Ala Glu Tyr Glu Met Val Ile Thr Asn Leu Gln
785                 790                 795                 800 
Pro Glu Thr Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly
                805                 810                 815     
Asp Gly Ala Arg Ser Lys Pro Lys Val Val Val Thr Lys Gly Ala Val
            820                 825                 830         
Leu Gly Arg Pro Thr Leu Ser Val Gln Gln Thr Pro Glu Gly Ser Leu
        835                 840                 845             
Leu Ala Arg Trp Glu Pro Pro Ala Gly Thr Ala Glu Asp Gln Val Leu
    850                 855                 860                 
Gly Tyr Arg Leu Gln Phe Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr
865                 870                 875                 880 
Leu Glu Phe Pro Pro Ser Glu Asp Arg Tyr Thr Ala Ser Gly Val His
                885                 890                 895     
Lys Gly Ala Thr Tyr Val Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly
            900                 905                 910         
Leu Gly Glu Glu Ala Ala Glu Val Leu Ser Ile Pro Glu Asp Thr Pro
        915                 920                 925             
Arg Gly His Pro Gln Ile Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly
    930                 935                 940                 
Thr Val Leu Leu Arg Trp Leu Pro Pro Val Pro Ala Glu Arg Asn Gly
945                 950                 955                 960 
Ala Ile Val Lys Tyr Thr Val Ala Val Arg Glu Ala Gly Ala Leu Gly
                965                 970                 975     
Pro Ala Arg Glu Thr Glu Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu
            980                 985                 990         
Asn Ala Val Thr Leu Gln Gly Leu Lys Pro Asp Thr Ala Tyr Asp Leu
        995                 1000                1005            
Gln Val Arg Ala His Thr Arg Arg Gly Pro Gly Pro Phe Ser Pro Pro
    1010                1015                1020                
Val Arg Tyr Arg Thr Phe Leu Arg Asp Gln Val Ser Pro Lys Asn Phe
1025                1030                1035                1040
Lys Val Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe
                1045                1050                1055    
Pro Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly
            1060                1065                1070        
Leu Thr Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His
        1075                1080                1085            
Leu Lys Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser
    1090                1095                1100                
Ser Leu Gly Gly Leu Gln Gln Thr Val Thr Ala Trp Thr Ala Phe Asn
1105                1110                1115                1120
Leu Leu Asn Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Ala Asp Gly
                1125                1130                1135    
Phe Ile Met Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Pro Val Gln
            1140                1145                1150        
Ser Tyr Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln
        1155                1160                1165            
Phe Leu Thr Pro Leu Gly Ser Pro Glu Asp Met Asp Leu Glu Glu Leu
    1170                1175                1180                
Ile Gln Asp Ile Ser Arg Leu Gln Arg Arg Thr Val Arg His Ser Arg
1185                1190                1195                1200
Gln Leu Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val Leu
                1205                1210                1215    
Pro Pro Thr Phe His Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe Asp
            1220                1225                1230        
Asn Arg Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala
        1235                1240                1245            
Val Leu Gln Lys Ser Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp
    1250                1255                1260                
Pro Phe Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu
1265                1270                1275                1280
Glu Gly Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe Ile
                1285                1290                1295    
Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser
            1300                1305                1310        
Lys Arg Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala
        1315                1320                1325            
Asp Leu Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg Ile
    1330                1335                1340                
Asn Phe Gln Thr Pro Asp Ser Gly Leu Arg Ser Pro Leu Arg Glu Pro
1345                1350                1355                1360
Gly Phe His Phe Glu Ser Met Leu Ser His Pro Pro Ile Pro Ile Ala
                1365                1370                1375    
Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys
            1380                1385                1390        
Leu Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp
        1395                1400                1405            
Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn
    1410                1415                1420                
Val Ile Ala Tyr Asp His Phe Arg Val Ile Leu Gln Pro Ile Glu Gly
1425                1430                1435                1440
Ile Met Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg
                1445                1450                1455    
Arg Gln Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe
            1460                1465                1470        
Gly Asp Phe Trp Arg Met Val Trp Glu Gln Arg Ser Ala Thr Ile Val
        1475                1480                1485            
Met Met Thr Arg Leu Glu Glu Lys Ser Arg Ile Lys Cys Asp Gln Tyr
    1490                1495                1500                
Trp Pro Asn Arg Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu
1505                1510                1515                1520
Leu Asp Thr Ile Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu
                1525                1530                1535    
His Lys Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe
            1540                1545                1550        
Thr Ala Trp Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu
        1555                1560                1565            
Ala Phe Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro
    1570                1575                1580                
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile
1585                1590                1595                1600
Val Ile Asp Ala Met Leu Glu Arg Ile Lys Pro Glu Lys Thr Val Asp
                1605                1610                1615    
Val Tyr Gly His Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met Val
            1620                1625                1630        
Gln Thr Glu Asp Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Ala
        1635                1640                1645            
Val Gly Cys Gly Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Ala Tyr
    1650                1655                1660                
Ile Gln Lys Leu Ala Gln Val Glu Pro Gly Glu His Val Thr Gly Met
1665                1670                1675                1680
Glu Leu Glu Phe Lys Arg Leu Ala Asn Ser Lys Ala His Thr Ser Arg
                1685                1690                1695    
Phe Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val
            1700                1705                1710        
Asn Ile Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg
        1715                1720                1725            
Gly Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr
    1730                1735                1740                
Arg Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr
1745                1750                1755                1760
Thr Glu Asp Phe Trp Arg Met Leu Trp Glu Asn Asn Ser Thr Ile Val
                1765                1770                1775    
Val Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln
            1780                1785                1790        
Tyr Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp
        1795                1800                1805            
Pro Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys
    1810                1815                1820                
Val Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln
1825                1830                1835                1840
Phe Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe
                1845                1850                1855    
Ile Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln
            1860                1865                1870        
Asp Gly Pro Ile Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly
        1875                1880                1885            
Val Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly
    1890                1895                1900                
Val Val Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro
1905                1910                1915                1920
Ala Met Val Gln Thr Glu Asp Glu Tyr Gln Phe Cys Tyr Gln Ala Ala
                1925                1930                1935    
Leu Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr
            1940                1945            


<210> 9353
<211> 1928
<212> PRT
<213> Homo sapiens

<400> 9353
Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met
 1               5                  10                  15      
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro
            20                  25                  30          
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly
        35                  40                  45              
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val
    50                  55                  60                  
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr
65                  70                  75                  80  
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu
                85                  90                  95      
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser
            100                 105                 110         
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp
        115                 120                 125             
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys
    130                 135                 140                 
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly
145                 150                 155                 160 
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp
                165                 170                 175     
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe
            180                 185                 190         
Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu
        195                 200                 205             
Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val
    210                 215                 220                 
Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Val Arg Arg Val Ala
225                 230                 235                 240 
Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile Met Pro Gly Gly
                245                 250                 255     
Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val
            260                 265                 270         
Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro
        275                 280                 285             
Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys Asp Ser Ala Asn
    290                 295                 300                 
Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile Glu Ala Val Ala
305                 310                 315                 320 
Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly Thr Pro Met Val
                325                 330                 335     
Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp Asp Ser Gly Asn
            340                 345                 350         
Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys Ser Lys Ser Gln
        355                 360                 365             
Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr Thr Arg Tyr Ser
    370                 375                 380                 
Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile Trp Val Ser Ala
385                 390                 395                 400 
Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser Val Val Thr Arg
                405                 410                 415     
Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn Val Gln Ala Arg
            420                 425                 430         
Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu Glu Pro Val Glu
        435                 440                 445             
Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr Thr Met Glu Pro
    450                 455                 460                 
Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val Asp Asp Ser Leu
465                 470                 475                 480 
Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr Tyr Thr Val Arg
                485                 490                 495     
Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu Ser Asp Pro Ile
            500                 505                 510         
Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro Met Asn Leu Arg
        515                 520                 525             
Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser Trp Ser Pro Pro
    530                 535                 540                 
Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe Arg Glu Gly Asp
545                 550                 555                 560 
His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr Thr Ser Tyr Val
                565                 570                 575     
Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe Arg Leu Ala Ala
            580                 585                 590         
Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val Val Arg Gln Arg
        595                 600                 605             
Thr Leu Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp Val Lys Cys Val
    610                 615                 620                 
Ser Val Arg Ser Thr Ala Ile Leu Val Ser Trp Arg Pro Pro Pro Pro
625                 630                 635                 640 
Glu Thr His Asn Gly Ala Leu Val Gly Tyr Ser Val Arg Tyr Arg Pro
                645                 650                 655     
Leu Gly Ser Glu Asp Pro Glu Pro Lys Glu Val Asn Gly Ile Pro Pro
            660                 665                 670         
Thr Thr Thr Gln Ile Leu Leu Glu Ala Leu Glu Lys Trp Thr Gln Tyr
        675                 680                 685             
Arg Ile Thr Thr Val Ala His Thr Glu Val Gly Pro Gly Pro Glu Ser
    690                 695                 700                 
Ser Pro Val Val Val Arg Thr Asp Glu Asp Val Pro Ser Ala Pro Pro
705                 710                 715                 720 
Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala Ile Arg Val Leu
                725                 730                 735     
Trp Leu Gly Pro Val Pro Gly Arg Gln His Gly Gln Ile Arg Gly Tyr
            740                 745                 750         
Gln Val His Tyr Val Arg Met Glu Gly Ala Glu Gly Arg Gly Pro Pro
        755                 760                 765             
Arg Ile Lys Asp Val Met Leu Ala Asp Ala Gln Trp Glu Thr Asp Asp
    770                 775                 780                 
Thr Ala Glu Tyr Glu Met Val Ile Thr Asn Leu Gln Pro Glu Thr Ala
785                 790                 795                 800 
Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala Arg
                805                 810                 815     
Ser Lys Pro Lys Val Val Val Thr Lys Gly Ala Val Leu Gly Arg Pro
            820                 825                 830         
Thr Leu Ser Val Gln Gln Thr Pro Glu Gly Ser Leu Leu Ala Arg Trp
        835                 840                 845             
Glu Pro Pro Ala Gly Thr Ala Glu Asp Gln Val Leu Gly Tyr Arg Leu
    850                 855                 860                 
Gln Phe Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr Leu Glu Phe Pro
865                 870                 875                 880 
Pro Ser Glu Asp Arg Tyr Thr Ala Ser Gly Val His Lys Gly Ala Thr
                885                 890                 895     
Tyr Val Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly Leu Gly Glu Glu
            900                 905                 910         
Ala Ala Glu Val Leu Ser Ile Pro Glu Asp Thr Pro Arg Gly His Pro
        915                 920                 925             
Gln Ile Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly Thr Val Leu Leu
    930                 935                 940                 
Arg Trp Leu Pro Pro Val Pro Ala Glu Arg Asn Gly Ala Ile Val Lys
945                 950                 955                 960 
Tyr Thr Val Ala Val Arg Glu Ala Gly Ala Leu Gly Pro Ala Arg Glu
                965                 970                 975     
Thr Glu Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu Asn Ala Val Thr
            980                 985                 990         
Leu Gln Gly Leu Lys Pro Asp Thr Ala Tyr Asp Leu Gln Val Arg Ala
        995                 1000                1005            
His Thr Arg Arg Gly Pro Gly Pro Phe Ser Pro Pro Val Arg Tyr Arg
    1010                1015                1020                
Thr Phe Leu Arg Asp Gln Val Ser Pro Lys Asn Phe Lys Val Lys Met
1025                1030                1035                1040
Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe Pro Asp Asn Tyr
                1045                1050                1055    
Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly Leu Thr Leu Asp
            1060                1065                1070        
Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His Leu Lys Pro His
        1075                1080                1085            
Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser Ser Leu Gly Gly
    1090                1095                1100                
Leu Gln Gln Thr Val Thr Ala Trp Thr Ala Phe Asn Leu Leu Asn Gly
1105                1110                1115                1120
Lys Pro Ser Val Ala Pro Lys Pro Asp Ala Asp Gly Phe Ile Met Val
                1125                1130                1135    
Tyr Leu Pro Asp Gly Gln Ser Pro Val Pro Val Gln Ser Tyr Phe Ile
            1140                1145                1150        
Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln Phe Leu Thr Pro
        1155                1160                1165            
Leu Gly Ser Pro Glu Asp Met Asp Leu Glu Glu Leu Ile Gln Asp Ile
    1170                1175                1180                
Ser Arg Leu Gln Arg Arg Thr Val Arg His Ser Arg Gln Leu Glu Val
1185                1190                1195                1200
Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val Leu Pro Pro Thr Phe
                1205                1210                1215    
His Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe Asp Asn Arg Gly Leu
            1220                1225                1230        
Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala Val Leu Gln Lys
        1235                1240                1245            
Ser Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp Pro Phe Gln Leu
    1250                1255                1260                
Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu Glu Gly Leu Ile
1265                1270                1275                1280
Trp Val Ile Gly Pro Val Leu Ala Val Val Phe Ile Ile Cys Ile Val
                1285                1290                1295    
Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser Lys Arg Lys Asp
            1300                1305                1310        
Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala Asp Leu Ala Pro
        1315                1320                1325            
His His Pro Lys Asp Pro Val Glu Met Arg Arg Ile Asn Phe Gln Thr
    1330                1335                1340                
Pro Gly Met Leu Ser His Pro Pro Ile Pro Ile Ala Asp Met Ala Glu
1345                1350                1355                1360
His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu
                1365                1370                1375    
Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His Ser Asn
            1380                1385                1390        
Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr
        1395                1400                1405            
Asp His Phe Arg Val Ile Leu Gln Pro Ile Glu Gly Ile Met Gly Ser
    1410                1415                1420                
Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg Arg Gln Asn Ala
1425                1430                1435                1440
Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe Gly Asp Phe Trp
                1445                1450                1455    
Arg Met Val Trp Glu Gln Arg Ser Ala Thr Ile Val Met Met Thr Arg
            1460                1465                1470        
Leu Glu Glu Lys Ser Arg Ile Lys Cys Asp Gln Tyr Trp Pro Asn Arg
        1475                1480                1485            
Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu Leu Asp Thr Ile
    1490                1495                1500                
Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu His Lys Asn Gly
1505                1510                1515                1520
Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe Thr Ala Trp Pro
                1525                1530                1535    
Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu Ala Phe Leu Arg
            1540                1545                1550        
Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Ile Val Val His
        1555                1560                1565            
Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile Asp Ala
    1570                1575                1580                
Met Leu Glu Arg Ile Lys Pro Glu Lys Thr Val Asp Val Tyr Gly His
1585                1590                1595                1600
Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met Val Gln Thr Glu Asp
                1605                1610                1615    
Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Ala Val Gly Cys Gly
            1620                1625                1630        
Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Ala Tyr Ile Gln Lys Leu
        1635                1640                1645            
Ala Gln Val Glu Pro Gly Glu His Val Thr Gly Met Glu Leu Glu Phe
    1650                1655                1660                
Lys Arg Leu Ala Asn Ser Lys Ala His Thr Ser Arg Phe Ile Ser Ala
1665                1670                1675                1680
Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile Met Pro
                1685                1690                1695    
Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg Gly Val Glu Gly
            1700                1705                1710        
Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Gln Lys
        1715                1720                1725            
Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr Glu Asp Phe
    1730                1735                1740                
Trp Arg Met Leu Trp Glu Asn Asn Ser Thr Ile Val Val Met Leu Thr
1745                1750                1755                1760
Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp Pro Ala
                1765                1770                1775    
Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met Ala Glu
            1780                1785                1790        
Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp Ala
        1795                1800                1805            
Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln Phe Thr Asp Trp
    1810                1815                1820                
Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile
1825                1830                1835                1840
Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile
                1845                1850                1855    
Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr
            1860                1865                1870        
Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile
        1875                1880                1885            
Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro Ala Met Val Gln
    1890                1895                1900                
Thr Glu Asp Glu Tyr Gln Phe Cys Tyr Gln Ala Ala Leu Glu Tyr Leu
1905                1910                1915                1920
Gly Ser Phe Asp His Tyr Ala Thr
                1925            


<210> 9354
<211> 1501
<212> PRT
<213> Homo sapiens

<400> 9354
Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met
 1               5                  10                  15      
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro
            20                  25                  30          
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly
        35                  40                  45              
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val
    50                  55                  60                  
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr
65                  70                  75                  80  
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu
                85                  90                  95      
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser
            100                 105                 110         
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp
        115                 120                 125             
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys
    130                 135                 140                 
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly
145                 150                 155                 160 
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp
                165                 170                 175     
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu
            180                 185                 190         
Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val
        195                 200                 205             
Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr
    210                 215                 220                 
Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser
225                 230                 235                 240 
His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val
                245                 250                 255     
Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu
            260                 265                 270         
Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr
        275                 280                 285             
Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu
    290                 295                 300                 
Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys
305                 310                 315                 320 
Ala Pro Gly Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr
                325                 330                 335     
Ile Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile
            340                 345                 350         
Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp
        355                 360                 365             
Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu
    370                 375                 380                 
Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro
385                 390                 395                 400 
Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala
                405                 410                 415     
Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val
            420                 425                 430         
Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg
        435                 440                 445             
Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys
    450                 455                 460                 
His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu
465                 470                 475                 480 
Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp
                485                 490                 495     
Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro
            500                 505                 510         
Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile
        515                 520                 525             
Thr Leu Ser Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu
    530                 535                 540                 
Leu Leu Phe Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe
545                 550                 555                 560 
Asp Pro Thr Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu
                565                 570                 575     
Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe
            580                 585                 590         
Thr Pro Val Val Arg Gln Arg Thr Leu Gln Ser Ile Ser Pro Lys Asn
        595                 600                 605             
Phe Lys Val Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu
    610                 615                 620                 
Phe Pro Asp Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn
625                 630                 635                 640 
Gly Leu Thr Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr
                645                 650                 655     
His Leu Lys Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly
            660                 665                 670         
Ser Ser Leu Gly Gly Leu Gln Gln Thr Val Thr Ala Trp Thr Ala Phe
        675                 680                 685             
Asn Leu Leu Asn Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Ala Asp
    690                 695                 700                 
Gly Phe Ile Met Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Pro Val
705                 710                 715                 720 
Gln Ser Tyr Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly
                725                 730                 735     
Gln Phe Leu Thr Pro Leu Gly Ser Pro Glu Asp Met Asp Leu Glu Glu
            740                 745                 750         
Leu Ile Gln Asp Ile Ser Arg Leu Gln Arg Arg Ser Leu Arg His Ser
        755                 760                 765             
Arg Gln Leu Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val
    770                 775                 780                 
Leu Pro Pro Thr Phe His Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe
785                 790                 795                 800 
Asp Asn Arg Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu
                805                 810                 815     
Ala Val Leu Gln Lys Ser Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser
            820                 825                 830         
Asp Pro Phe Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly
        835                 840                 845             
Glu Glu Gly Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe
    850                 855                 860                 
Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp
865                 870                 875                 880 
Ser Lys Arg Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn
                885                 890                 895     
Ala Asp Leu Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg
            900                 905                 910         
Ile Asn Phe Gln Thr Pro Gly Met Leu Ser His Pro Pro Ile Pro Ile
        915                 920                 925             
Ala Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu
    930                 935                 940                 
Lys Leu Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr
945                 950                 955                 960 
Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala
                965                 970                 975     
Asn Val Ile Ala Tyr Asp His Ser Arg Val Ile Leu Gln Pro Ile Glu
            980                 985                 990         
Gly Ile Met Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr
        995                 1000                1005            
Arg Arg Gln Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr
    1010                1015                1020                
Phe Gly Asp Phe Trp Arg Met Val Trp Glu Gln Arg Ser Ala Thr Ile
1025                1030                1035                1040
Val Met Met Thr Arg Leu Glu Glu Lys Ser Arg Ile Lys Cys Asp Gln
                1045                1050                1055    
Tyr Trp Pro Asn Arg Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr
            1060                1065                1070        
Leu Leu Asp Thr Ile Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser
        1075                1080                1085            
Leu His Lys Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln
    1090                1095                1100                
Phe Thr Ala Trp Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe
1105                1110                1115                1120
Leu Ala Phe Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly
                1125                1130                1135    
Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe
            1140                1145                1150        
Ile Val Ile Asp Ala Met Leu Glu Arg Ile Lys Pro Glu Lys Thr Val
        1155                1160                1165            
Asp Val Tyr Gly His Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met
    1170                1175                1180                
Val Gln Thr Glu Asp Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu
1185                1190                1195                1200
Ala Val Gly Cys Gly Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Ala
                1205                1210                1215    
Tyr Ile Gln Lys Leu Ala Gln Val Glu Pro Gly Glu His Val Thr Gly
            1220                1225                1230        
Met Glu Leu Glu Phe Lys Arg Leu Ala Asn Ser Lys Ala His Thr Ser
        1235                1240                1245            
Arg Phe Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu
    1250                1255                1260                
Val Asn Ile Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile
1265                1270                1275                1280
Arg Gly Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly
                1285                1290                1295    
Tyr Arg Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu
            1300                1305                1310        
Thr Thr Glu Asp Phe Trp Arg Met Leu Trp Glu Asn Asn Ser Thr Ile
        1315                1320                1325            
Val Val Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His
    1330                1335                1340                
Gln Tyr Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val
1345                1350                1355                1360
Asp Pro Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe
                1365                1370                1375    
Lys Val Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe
            1380                1385                1390        
Gln Phe Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly
        1395                1400                1405            
Phe Ile Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly
    1410                1415                1420                
Gln Asp Gly Pro Ile Ser Val His Cys Ser Ala Gly Val Gly Arg Thr
1425                1430                1435                1440
Gly Val Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu
                1445                1450                1455    
Gly Val Val Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg
            1460                1465                1470        
Pro Ala Met Val Gln Thr Glu Asp Glu Tyr Gln Phe Cys Tyr Gln Ala
        1475                1480                1485            
Ala Leu Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr
    1490                1495                1500    


<210> 9355
<211> 1910
<212> PRT
<213> Homo sapiens

<400> 9355
Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met
 1               5                  10                  15      
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro
            20                  25                  30          
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly
        35                  40                  45              
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val
    50                  55                  60                  
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr
65                  70                  75                  80  
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu
                85                  90                  95      
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser
            100                 105                 110         
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp
        115                 120                 125             
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys
    130                 135                 140                 
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly
145                 150                 155                 160 
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp
                165                 170                 175     
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu
            180                 185                 190         
Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val
        195                 200                 205             
Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr
    210                 215                 220                 
Val Arg Val Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser
225                 230                 235                 240 
His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val
                245                 250                 255     
Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu
            260                 265                 270         
Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr
        275                 280                 285             
Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu
    290                 295                 300                 
Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys
305                 310                 315                 320 
Ala Pro Gly Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr
                325                 330                 335     
Ile Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile
            340                 345                 350         
Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp
        355                 360                 365             
Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu
    370                 375                 380                 
Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro
385                 390                 395                 400 
Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala
                405                 410                 415     
Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val
            420                 425                 430         
Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg
        435                 440                 445             
Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys
    450                 455                 460                 
His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu
465                 470                 475                 480 
Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp
                485                 490                 495     
Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro
            500                 505                 510         
Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile
        515                 520                 525             
Thr Leu Ser Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu
    530                 535                 540                 
Leu Leu Phe Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe
545                 550                 555                 560 
Asp Pro Thr Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu
                565                 570                 575     
Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe
            580                 585                 590         
Thr Pro Val Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro
        595                 600                 605             
Pro Gln Asp Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val
    610                 615                 620                 
Ser Trp Arg Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly
625                 630                 635                 640 
Tyr Ser Val Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys
                645                 650                 655     
Glu Val Asn Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala
            660                 665                 670         
Leu Glu Lys Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu
        675                 680                 685             
Val Gly Pro Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu
    690                 695                 700                 
Asp Val Pro Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn
705                 710                 715                 720 
Ala Thr Ala Ile Arg Val Leu Trp Arg Ser Pro Ala Pro Gly Arg Gln
                725                 730                 735     
His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly
            740                 745                 750         
Ala Glu Ala Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp
        755                 760                 765             
Ala Gln Glu Met Val Ile Thr Asn Leu Gln Pro Glu Thr Ala Tyr Ser
    770                 775                 780                 
Ile Thr Val Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala Arg Ser Lys
785                 790                 795                 800 
Pro Lys Val Val Val Thr Lys Gly Ala Val Leu Gly Arg Pro Thr Leu
                805                 810                 815     
Ser Val Gln Gln Thr Pro Glu Gly Ser Leu Leu Ala Arg Trp Glu Pro
            820                 825                 830         
Pro Ala Gly Thr Ala Glu Asp Gln Val Leu Gly Tyr Arg Leu Gln Phe
        835                 840                 845             
Gly Arg Glu Asp Ser Thr Pro Leu Ala Thr Leu Glu Phe Pro Pro Ser
    850                 855                 860                 
Glu Asp Arg Tyr Thr Ala Ser Gly Val His Lys Gly Ala Thr Tyr Val
865                 870                 875                 880 
Phe Arg Leu Ala Ala Arg Ser Arg Gly Gly Leu Gly Glu Glu Ala Ala
                885                 890                 895     
Glu Val Leu Ser Ile Pro Glu Asp Thr Pro Arg Gly His Pro Gln Ile
            900                 905                 910         
Leu Glu Ala Ala Gly Asn Ala Ser Ala Gly Thr Val Leu Leu Arg Trp
        915                 920                 925             
Leu Pro Pro Val Pro Ala Glu Arg Asn Gly Ala Ile Val Lys Tyr Thr
    930                 935                 940                 
Val Ala Val Arg Glu Ala Gly Ala Leu Gly Pro Ala Arg Glu Thr Glu
945                 950                 955                 960 
Leu Pro Ala Ala Ala Glu Pro Gly Ala Glu Asn Ala Leu Thr Leu Gln
                965                 970                 975     
Gly Leu Lys Pro Asp Thr Ala Tyr Asp Leu Gln Val Arg Ala His Thr
            980                 985                 990         
Arg Arg Gly Pro Gly Pro Phe Ser Pro Pro Val Arg Tyr Arg Thr Phe
        995                 1000                1005            
Leu Arg Asp Gln Val Ser Pro Lys Asn Phe Lys Val Lys Met Ile Met
    1010                1015                1020                
Lys Thr Ser Val Leu Leu Ser Trp Glu Phe Pro Asp Asn Tyr Asn Ser
1025                1030                1035                1040
Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly Leu Thr Leu Asp Val Asp
                1045                1050                1055    
Gly Arg Thr Thr Lys Lys Leu Ile Thr His Leu Lys Pro His Thr Phe
            1060                1065                1070        
Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser Ser Leu Gly Gly Leu Gln
        1075                1080                1085            
Gln Thr Val Thr Ala Trp Thr Ala Phe Asn Leu Leu Asn Gly Lys Pro
    1090                1095                1100                
Ser Val Ala Pro Lys Pro Asp Ala Asp Gly Phe Ile Met Val Tyr Leu
1105                1110                1115                1120
Pro Asp Gly Gln Ser Pro Val Pro Val Gln Ser Tyr Phe Ile Val Met
                1125                1130                1135    
Val Pro Leu Arg Lys Ser Arg Gly Gly Gln Phe Leu Thr Pro Leu Gly
            1140                1145                1150        
Ser Pro Glu Asp Met Asp Leu Glu Glu Leu Ile Gln Asp Ile Ser Arg
        1155                1160                1165            
Leu Gln Arg Arg Ser Leu Arg His Ser Arg Gln Leu Glu Val Pro Arg
    1170                1175                1180                
Pro Tyr Ile Ala Ala Arg Phe Ser Val Leu Pro Pro Thr Phe His Pro
1185                1190                1195                1200
Gly Asp Gln Lys Gln Tyr Gly Gly Phe Asp Asn Arg Gly Leu Glu Pro
                1205                1210                1215    
Gly His Arg Tyr Val Leu Phe Val Leu Ala Val Leu Gln Lys Ser Glu
            1220                1225                1230        
Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp Pro Phe Gln Leu Asp Asn
        1235                1240                1245            
Pro Asp Pro Gln Pro Ile Val Asp Gly Glu Glu Gly Leu Ile Trp Val
    1250                1255                1260                
Ile Gly Pro Val Leu Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala
1265                1270                1275                1280
Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser Lys Arg Lys Asp Ser Glu
                1285                1290                1295    
Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala Asp Leu Ala Pro His His
            1300                1305                1310        
Pro Lys Asp Pro Val Glu Met Arg Arg Ile Asn Phe Gln Thr Pro Gly
        1315                1320                1325            
Met Leu Ser His Pro Pro Ile Pro Ile Ala Asp Met Ala Glu His Thr
    1330                1335                1340                
Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr Glu
1345                1350                1355                1360
Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His Ser Asn Leu Glu
                1365                1370                1375    
Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp His
            1380                1385                1390        
Ser Arg Val Ile Leu Gln Pro Ile Glu Gly Ile Met Gly Ser Asp Tyr
        1395                1400                1405            
Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg Arg Gln Asn Ala Tyr Ile
    1410                1415                1420                
Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe Gly Asp Phe Trp Arg Met
1425                1430                1435                1440
Val Trp Glu Gln Arg Ser Ala Thr Ile Val Met Met Thr Arg Leu Glu
                1445                1450                1455    
Glu Lys Ser Arg Ile Lys Cys Asp Gln Tyr Trp Pro Asn Arg Gly Thr
            1460                1465                1470        
Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu Leu Asp Thr Ile Glu Leu
        1475                1480                1485            
Ala Thr Phe Cys Val Arg Thr Phe Ser Leu His Lys Asn Gly Ser Ser
    1490                1495                1500                
Glu Lys Arg Glu Val Arg Gln Phe Gln Phe Thr Ala Trp Pro Asp His
1505                1510                1515                1520
Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu Ala Phe Leu Arg Arg Val
                1525                1530                1535    
Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Ile Val Val His Cys Ser
            1540                1545                1550        
Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile Asp Ala Met Leu
        1555                1560                1565            
Glu Arg Ile Lys Pro Glu Lys Thr Val Asp Val Tyr Gly His Val Thr
    1570                1575                1580                
Leu Met Arg Ser Gln Arg Asn Tyr Met Val Gln Thr Glu Asp Gln Tyr
1585                1590                1595                1600
Ser Phe Ile His Glu Ala Leu Leu Glu Ala Val Gly Cys Gly Asn Thr
                1605                1610                1615    
Glu Val Pro Ala Arg Ser Leu Tyr Ala Tyr Ile Gln Lys Leu Ala Gln
            1620                1625                1630        
Val Glu Pro Gly Glu His Val Thr Gly Met Glu Leu Glu Phe Lys Arg
        1635                1640                1645            
Leu Ala Asn Ser Lys Ala His Thr Ser Arg Phe Ile Ser Ala Asn Leu
    1650                1655                1660                
Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile Met Pro Tyr Glu
1665                1670                1675                1680
Ser Thr Arg Val Cys Leu Gln Pro Ile Arg Gly Val Glu Gly Ser Asp
                1685                1690                1695    
Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Gln Lys Ala Tyr
            1700                1705                1710        
Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr Glu Asp Phe Trp Arg
        1715                1720                1725            
Met Leu Trp Glu Asn Asn Ser Thr Ile Val Val Met Leu Thr Lys Leu
    1730                1735                1740                
Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp Pro Ala Glu Arg
1745                1750                1755                1760
Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met Ala Glu Tyr Asn
                1765                1770                1775    
Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp Ala Arg Asp
            1780                1785                1790        
Gly Gln Ser Arg Thr Val Arg Gln Phe Gln Phe Thr Asp Trp Pro Glu
        1795                1800                1805            
Gln Gly Val Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile Gly Gln
    1810                1815                1820                
Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile Ser Val
1825                1830                1835                1840
His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr Leu Ser
                1845                1850                1855    
Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile Phe Gln
            1860                1865                1870        
Thr Val Lys Met Leu Arg Thr Gln Arg Pro Ala Met Val Gln Thr Glu
        1875                1880                1885            
Asp Glu Tyr Gln Phe Cys Tyr Gln Ala Ala Leu Glu Tyr Leu Gly Ser
    1890                1895                1900                
Phe Asp His Tyr Ala Thr
1905                1910


<210> 9356
<211> 1530
<212> PRT
<213> Homo sapiens

<400> 9356
Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met
 1               5                  10                  15      
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro
            20                  25                  30          
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly
        35                  40                  45              
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val
    50                  55                  60                  
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr
65                  70                  75                  80  
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu
                85                  90                  95      
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser
            100                 105                 110         
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp
        115                 120                 125             
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys
    130                 135                 140                 
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly
145                 150                 155                 160 
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp
                165                 170                 175     
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe
            180                 185                 190         
Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu
        195                 200                 205             
Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val
    210                 215                 220                 
Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu Val
225                 230                 235                 240 
Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile
                245                 250                 255     
Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro
            260                 265                 270         
Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu
        275                 280                 285             
Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys
    290                 295                 300                 
Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile
305                 310                 315                 320 
Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly
                325                 330                 335     
Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp
            340                 345                 350         
Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys
        355                 360                 365             
Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr
    370                 375                 380                 
Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile
385                 390                 395                 400 
Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser
                405                 410                 415     
Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn
            420                 425                 430         
Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu
        435                 440                 445             
Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr
    450                 455                 460                 
Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val
465                 470                 475                 480 
Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr
                485                 490                 495     
Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu
            500                 505                 510         
Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro
        515                 520                 525             
Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser
    530                 535                 540                 
Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe
545                 550                 555                 560 
Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr
                565                 570                 575     
Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe
            580                 585                 590         
Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val
        595                 600                 605             
Val Arg Gln Arg Thr Leu Gln Ser Ile Ser Pro Lys Asn Phe Lys Val
    610                 615                 620                 
Lys Met Ile Met Lys Thr Ser Val Leu Leu Ser Trp Glu Phe Pro Asp
625                 630                 635                 640 
Asn Tyr Asn Ser Pro Thr Pro Tyr Lys Ile Gln Tyr Asn Gly Leu Thr
                645                 650                 655     
Leu Asp Val Asp Gly Arg Thr Thr Lys Lys Leu Ile Thr His Leu Lys
            660                 665                 670         
Pro His Thr Phe Tyr Asn Phe Val Leu Thr Asn Arg Gly Ser Ser Leu
        675                 680                 685             
Gly Gly Leu Gln Gln Thr Val Thr Ala Trp Thr Ala Phe Asn Leu Leu
    690                 695                 700                 
Asn Gly Lys Pro Ser Val Ala Pro Lys Pro Asp Ala Asp Gly Phe Ile
705                 710                 715                 720 
Met Val Tyr Leu Pro Asp Gly Gln Ser Pro Val Pro Val Gln Ser Tyr
                725                 730                 735     
Phe Ile Val Met Val Pro Leu Arg Lys Ser Arg Gly Gly Gln Phe Leu
            740                 745                 750         
Thr Pro Leu Gly Ser Pro Glu Asp Met Asp Leu Glu Glu Leu Ile Gln
        755                 760                 765             
Asp Ile Ser Arg Leu Gln Arg Arg Thr Val Arg His Ser Arg Gln Leu
    770                 775                 780                 
Glu Val Pro Arg Pro Tyr Ile Ala Ala Arg Phe Ser Val Leu Pro Pro
785                 790                 795                 800 
Thr Phe His Pro Gly Asp Gln Lys Gln Tyr Gly Gly Phe Asp Asn Arg
                805                 810                 815     
Gly Leu Glu Pro Gly His Arg Tyr Val Leu Phe Val Leu Ala Val Leu
            820                 825                 830         
Gln Lys Ser Glu Pro Thr Phe Ala Ala Ser Pro Phe Ser Asp Pro Phe
        835                 840                 845             
Gln Leu Asp Asn Pro Asp Pro Gln Pro Ile Val Asp Gly Glu Glu Gly
    850                 855                 860                 
Leu Ile Trp Val Ile Gly Pro Val Leu Ala Val Val Phe Ile Ile Cys
865                 870                 875                 880 
Ile Val Ile Ala Ile Leu Leu Tyr Lys Asn Lys Pro Asp Ser Lys Arg
                885                 890                 895     
Lys Asp Ser Glu Pro Arg Thr Lys Cys Leu Leu Asn Asn Ala Asp Leu
            900                 905                 910         
Ala Pro His His Pro Lys Asp Pro Val Glu Met Arg Arg Ile Asn Phe
        915                 920                 925             
Gln Thr Pro Asp Ser Gly Leu Arg Ser Pro Leu Arg Glu Pro Gly Phe
    930                 935                 940                 
His Phe Glu Ser Met Leu Ser His Pro Pro Ile Pro Ile Ala Asp Met
945                 950                 955                 960 
Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser
                965                 970                 975     
Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His
            980                 985                 990         
Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile
        995                 1000                1005            
Ala Tyr Asp His Phe Arg Val Ile Leu Gln Pro Ile Glu Gly Ile Met
    1010                1015                1020                
Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Arg Arg Gln
1025                1030                1035                1040
Asn Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Glu Thr Phe Gly Asp
                1045                1050                1055    
Phe Trp Arg Met Val Trp Glu Gln Arg Ser Ala Thr Ile Val Met Met
            1060                1065                1070        
Thr Arg Leu Glu Glu Lys Ser Arg Ile Lys Cys Asp Gln Tyr Trp Pro
        1075                1080                1085            
Asn Arg Gly Thr Glu Thr Tyr Gly Phe Ile Gln Val Thr Leu Leu Asp
    1090                1095                1100                
Thr Ile Glu Leu Ala Thr Phe Cys Val Arg Thr Phe Ser Leu His Lys
1105                1110                1115                1120
Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe Thr Ala
                1125                1130                1135    
Trp Pro Asp His Gly Val Pro Glu Tyr Pro Thr Pro Phe Leu Ala Phe
            1140                1145                1150        
Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Ile Val
        1155                1160                1165            
Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile
    1170                1175                1180                
Asp Ala Met Leu Glu Arg Ile Lys Pro Glu Lys Thr Val Asp Val Tyr
1185                1190                1195                1200
Gly His Val Thr Leu Met Arg Ser Gln Arg Asn Tyr Met Val Gln Thr
                1205                1210                1215    
Glu Asp Gln Tyr Ser Phe Ile His Glu Ala Leu Leu Glu Ala Val Gly
            1220                1225                1230        
Cys Gly Asn Thr Glu Val Pro Ala Arg Ser Leu Tyr Ala Tyr Ile Gln
        1235                1240                1245            
Lys Leu Ala Gln Val Glu Pro Gly Glu His Val Thr Gly Met Glu Leu
    1250                1255                1260                
Glu Phe Lys Arg Leu Ala Asn Ser Lys Ala His Thr Ser Arg Phe Ile
1265                1270                1275                1280
Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile
                1285                1290                1295    
Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg Gly Val
            1300                1305                1310        
Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln
        1315                1320                1325            
Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr Glu
    1330                1335                1340                
Asp Phe Trp Arg Met Leu Trp Glu Asn Asn Ser Thr Ile Val Val Met
1345                1350                1355                1360
Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp
                1365                1370                1375    
Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met
            1380                1385                1390        
Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val Thr
        1395                1400                1405            
Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln Phe Thr
    1410                1415                1420                
Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe Ile Asp
1425                1430                1435                1440
Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly
                1445                1450                1455    
Pro Ile Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe
            1460                1465                1470        
Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val
        1475                1480                1485            
Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro Ala Met
    1490                1495                1500                
Val Gln Thr Glu Asp Glu Tyr Gln Phe Cys Tyr Gln Ala Ala Leu Glu
1505                1510                1515                1520
Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr
                1525                1530


<210> 9357
<211> 1939
<212> PRT
<213> Homo sapiens

<400> 9357
Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met
 1               5                  10                  15      
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro
            20                  25                  30          
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly
        35                  40                  45              
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val
    50                  55                  60                  
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr
65                  70                  75                  80  
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu
                85                  90                  95      
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser
            100                 105                 110         
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp
        115                 120                 125             
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys
    130                 135                 140                 
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly
145                 150                 155                 160 
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp
                165                 170                 175     
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Glu Thr Phe
            180                 185                 190         
Glu Ser Thr Pro Ile Arg Gly Ala Leu Gln Ile Glu Ser Ser Glu Glu
        195                 200                 205             
Thr Asp Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Val
    210                 215                 220                 
Arg Tyr Ser Ser Pro Ala Asn Leu Tyr Val Arg Glu Leu Arg Glu Val
225                 230                 235                 240 
Arg Arg Val Ala Pro Arg Phe Ser Ile Leu Pro Met Ser His Glu Ile
                245                 250                 255     
Met Pro Gly Gly Asn Val Asn Ile Thr Cys Val Ala Val Gly Ser Pro
            260                 265                 270         
Met Pro Tyr Val Lys Trp Met Gln Gly Ala Glu Asp Leu Thr Pro Glu
        275                 280                 285             
Asp Asp Met Pro Val Gly Arg Asn Val Leu Glu Leu Thr Asp Val Lys
    290                 295                 300                 
Asp Ser Ala Asn Tyr Thr Cys Val Ala Met Ser Ser Leu Gly Val Ile
305                 310                 315                 320 
Glu Ala Val Ala Gln Ile Thr Val Lys Ser Leu Pro Lys Ala Pro Gly
                325                 330                 335     
Thr Pro Met Val Thr Glu Asn Thr Ala Thr Ser Ile Thr Ile Thr Trp
            340                 345                 350         
Asp Ser Gly Asn Pro Asp Pro Val Ser Tyr Tyr Val Ile Glu Tyr Lys
        355                 360                 365             
Ser Lys Ser Gln Asp Gly Pro Tyr Gln Ile Lys Glu Asp Ile Thr Thr
    370                 375                 380                 
Thr Arg Tyr Ser Ile Gly Gly Leu Ser Pro Asn Ser Glu Tyr Glu Ile
385                 390                 395                 400 
Trp Val Ser Ala Val Asn Ser Ile Gly Gln Gly Pro Pro Ser Glu Ser
                405                 410                 415     
Val Val Thr Arg Thr Gly Glu Gln Ala Pro Ala Ser Ala Pro Arg Asn
            420                 425                 430         
Val Gln Ala Arg Met Leu Ser Ala Thr Thr Met Ile Val Gln Trp Glu
        435                 440                 445             
Glu Pro Val Glu Pro Asn Gly Leu Ile Arg Gly Tyr Arg Val Tyr Tyr
    450                 455                 460                 
Thr Met Glu Pro Glu His Pro Val Gly Asn Trp Gln Lys His Asn Val
465                 470                 475                 480 
Asp Asp Ser Leu Leu Thr Thr Val Gly Ser Leu Leu Glu Asp Glu Thr
                485                 490                 495     
Tyr Thr Val Arg Val Leu Ala Phe Thr Ser Val Gly Asp Gly Pro Leu
            500                 505                 510         
Ser Asp Pro Ile Gln Val Lys Thr Gln Gln Gly Val Pro Gly Gln Pro
        515                 520                 525             
Met Asn Leu Arg Ala Glu Ala Arg Ser Glu Thr Ser Ile Thr Leu Ser
    530                 535                 540                 
Trp Ser Pro Pro Arg Gln Glu Ser Ile Ile Lys Tyr Glu Leu Leu Phe
545                 550                 555                 560 
Arg Glu Gly Asp His Gly Arg Glu Val Gly Arg Thr Phe Asp Pro Thr
                565                 570                 575     
Thr Ser Tyr Val Val Glu Asp Leu Lys Pro Asn Thr Glu Tyr Ala Phe
            580                 585                 590         
Arg Leu Ala Ala Arg Ser Pro Gln Gly Leu Gly Ala Phe Thr Pro Val
        595                 600                 605             
Val Arg Gln Arg Thr Leu Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp
    610                 615                 620                 
Val Lys Cys Val Ser Val Arg Ser Thr Ala Ile Leu Val Ser Trp Arg
625                 630                 635                 640 
Pro Pro Pro Pro Glu Thr His Asn Gly Ala Leu Val Gly Tyr Ser Val
                645                 650                 655     
Arg Tyr Arg Pro Leu Gly Ser Glu Asp Pro Glu Pro Lys Glu Val Asn
            660                 665                 670         
Gly Ile Pro Pro Thr Thr Thr Gln Ile Leu Leu Glu Ala Leu Glu Lys
        675                 680                 685             
Trp Thr Gln Tyr Arg Ile Thr Thr Val Ala His Thr Glu Val Gly Pro
    690                 695                 700                 
Gly Pro Glu Ser Ser Pro Val Val Val Arg Thr Asp Glu Asp Val Pro
705                 710                 715                 720 
Ser Ala Pro Pro Arg Lys Val Glu Ala Glu Ala Leu Asn Ala Thr Ala
                725                 730                 735     
Ile Arg Val Leu Trp Leu Gly Pro Val Pro Gly Arg Gln His Gly Gln
            740                 745                 750         
Ile Arg Gly Tyr Gln Val His Tyr Val Arg Met Glu Gly Ala Glu Gly
        755                 760                 765             
Arg Gly Pro Pro Arg Ile Lys Asp Val Met Leu Ala Asp Ala Gln Glu
    770                 775                 780                 
Met Val Ile Thr Asn Leu Gln Pro Glu Thr Ala Tyr Ser Ile Thr Val
785                 790                 795                 800 
Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala Arg Ser Lys Pro Lys Val
                805                 810                 815     
Val Val Thr Lys Gly Ala Val Leu Gly Arg Pro Thr Leu Ser Val Gln
            820                 825                 830         
Gln Thr Pro Glu Gly Ser Leu Leu Ala Arg Trp Glu Pro Pro Ala Gly
        835                 840                 845             
Thr Ala Glu Asp Gln Val Leu Gly Tyr Arg Leu Gln Phe Gly Arg Glu
    850                 855                 860                 
Asp Ser Thr Pro Leu Ala Thr Leu Glu Phe Pro Pro Ser Glu Asp Arg
865                 870                 875                 880 
Tyr Thr Ala Ser Gly Val His Lys Gly Ala Thr Tyr Val Phe Arg Leu
                885                 890                 895     
Ala Ala Arg Ser Arg Gly Gly Leu Gly Glu Glu Ala Ala Glu Val Leu
            900                 905                 910         
Ser Ile Pro Glu Asp Thr Pro Arg Gly His Pro Gln Ile Leu Glu Ala
        915                 920                 925             
Ala Gly Asn Ala Ser Ala Gly Thr Val Leu Leu Arg Trp Leu Pro Pro
    930                 935                 940                 
Val Pro Ala Glu Arg Asn Gly Ala Ile Val Lys Tyr Thr Val Ala Val
945                 950                 955                 960 
Arg Glu Ala Gly Ala Leu Gly Pro Ala Arg Glu Thr Glu Leu Pro Ala
                965                 970                 975     
Ala Ala Glu Pro Gly Ala Glu Asn Ala Val Thr Leu Gln Gly Leu Lys
            980                 985                 990         
Pro Asp Thr Ala Tyr Asp Leu Gln Val Arg Ala His Thr Arg Arg Gly
        995                 1000                1005            
Pro Gly Pro Phe Ser Pro Pro Val Arg Tyr Arg Thr Phe Leu Arg Asp
    1010                1015                1020                
Gln Val Ser Pro Lys Asn Phe Lys Val Lys Met Ile Met Lys Thr Ser
1025                1030                1035                1040
Val Leu Leu Ser Trp Glu Phe Pro Asp Asn Tyr Asn Ser Pro Thr Pro
                1045                1050                1055    
Tyr Lys Ile Gln Tyr Asn Gly Leu Thr Leu Asp Val Asp Gly Arg Thr
            1060                1065                1070        
Thr Lys Lys Leu Ile Thr His Leu Lys Pro His Thr Phe Tyr Asn Phe
        1075                1080                1085            
Val Leu Thr Asn Arg Gly Ser Ser Leu Gly Gly Leu Gln Gln Thr Val
    1090                1095                1100                
Thr Ala Trp Thr Ala Phe Asn Leu Leu Asn Gly Lys Pro Ser Val Ala
1105                1110                1115                1120
Pro Lys Pro Asp Ala Asp Gly Phe Ile Met Val Tyr Leu Pro Asp Gly
                1125                1130                1135    
Gln Ser Pro Val Pro Val Gln Ser Tyr Phe Ile Val Met Val Pro Leu
            1140                1145                1150        
Arg Lys Ser Arg Gly Gly Gln Phe Leu Thr Pro Leu Gly Ser Pro Glu
        1155                1160                1165            
Asp Met Asp Leu Glu Glu Leu Ile Gln Asp Ile Ser Arg Leu Gln Arg
    1170                1175                1180                
Arg Thr Val Arg His Ser Arg Gln Leu Glu Val Pro Arg Pro Tyr Ile
1185                1190                1195                1200
Ala Ala Arg Phe Ser Val Leu Pro Pro Thr Phe His Pro Gly Asp Gln
                1205                1210                1215    
Lys Gln Tyr Gly Gly Phe Asp Asn Arg Gly Leu Glu Pro Gly His Arg
            1220                1225                1230        
Tyr Val Leu Phe Val Leu Ala Val Leu Gln Lys Ser Glu Pro Thr Phe
        1235                1240                1245            
Ala Ala Ser Pro Phe Ser Asp Pro Phe Gln Leu Asp Asn Pro Asp Pro
    1250                1255                1260                
Gln Pro Ile Val Asp Gly Glu Glu Gly Leu Ile Trp Val Ile Gly Pro
1265                1270                1275                1280
Val Leu Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu
                1285                1290                1295    
Tyr Lys Asn Lys Pro Asp Ser Lys Arg Lys Asp Ser Glu Pro Arg Thr
            1300                1305                1310        
Lys Cys Leu Leu Asn Asn Ala Asp Leu Ala Pro His His Pro Lys Asp
        1315                1320                1325            
Pro Val Glu Met Arg Arg Ile Asn Phe Gln Thr Pro Asp Ser Gly Leu
    1330                1335                1340                
Arg Ser Pro Leu Arg Glu Pro Gly Phe His Phe Glu Ser Met Leu Ser
1345                1350                1355                1360
His Pro Pro Ile Pro Ile Ala Asp Met Ala Glu His Thr Glu Arg Leu
                1365                1370                1375    
Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr Glu Ser Ile Asp
            1380                1385                1390        
Pro Gly Gln Gln Phe Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys
        1395                1400                1405            
Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp His Phe Arg Val
    1410                1415                1420                
Ile Leu Gln Pro Ile Glu Gly Ile Met Gly Ser Asp Tyr Ile Asn Ala
1425                1430                1435                1440
Asn Tyr Val Asp Gly Tyr Arg Arg Gln Asn Ala Tyr Ile Ala Thr Gln
                1445                1450                1455    
Gly Pro Leu Pro Glu Thr Phe Gly Asp Phe Trp Arg Met Val Trp Glu
            1460                1465                1470        
Gln Arg Ser Ala Thr Ile Val Met Met Thr Arg Leu Glu Glu Lys Ser
        1475                1480                1485            
Arg Ile Lys Cys Asp Gln Tyr Trp Pro Asn Arg Gly Thr Glu Thr Tyr
    1490                1495                1500                
Gly Phe Ile Gln Val Thr Leu Leu Asp Thr Ile Glu Leu Ala Thr Phe
1505                1510                1515                1520
Cys Val Arg Thr Phe Ser Leu His Lys Asn Gly Ser Ser Glu Lys Arg
                1525                1530                1535    
Glu Val Arg Gln Phe Gln Phe Thr Ala Trp Pro Asp His Gly Val Pro
            1540                1545                1550        
Glu Tyr Pro Thr Pro Phe Leu Ala Phe Leu Arg Arg Val Lys Thr Cys
        1555                1560                1565            
Asn Pro Pro Asp Ala Gly Pro Ile Val Val His Cys Ser Ala Gly Val
    1570                1575                1580                
Gly Arg Thr Gly Cys Phe Ile Val Ile Asp Ala Met Leu Glu Arg Ile
1585                1590                1595                1600
Lys Pro Glu Lys Thr Val Asp Val Tyr Gly His Val Thr Leu Met Arg
                1605                1610                1615    
Ser Gln Arg Asn Tyr Met Val Gln Thr Glu Asp Gln Tyr Ser Phe Ile
            1620                1625                1630        
His Glu Ala Leu Leu Glu Ala Val Gly Cys Gly Asn Thr Glu Val Pro
        1635                1640                1645            
Ala Arg Ser Leu Tyr Ala Tyr Ile Gln Lys Leu Ala Gln Val Glu Pro
    1650                1655                1660                
Gly Glu His Val Thr Gly Met Glu Leu Glu Phe Lys Arg Leu Ala Asn
1665                1670                1675                1680
Ser Lys Ala His Thr Ser Arg Phe Ile Ser Ala Asn Leu Pro Cys Asn
                1685                1690                1695    
Lys Phe Lys Asn Arg Leu Val Asn Ile Met Pro Tyr Glu Ser Thr Arg
            1700                1705                1710        
Val Cys Leu Gln Pro Ile Arg Gly Val Glu Gly Ser Asp Tyr Ile Asn
        1715                1720                1725            
Ala Ser Phe Ile Asp Gly Tyr Arg Gln Gln Lys Ala Tyr Ile Ala Thr
    1730                1735                1740                
Gln Gly Pro Leu Ala Glu Thr Thr Glu Asp Phe Trp Arg Met Leu Trp
1745                1750                1755                1760
Glu Asn Asn Ser Thr Ile Val Val Met Leu Thr Lys Leu Arg Glu Met
                1765                1770                1775    
Gly Arg Glu Lys Cys His Gln Tyr Trp Pro Ala Glu Arg Ser Ala Arg
            1780                1785                1790        
Tyr Gln Tyr Phe Val Val Asp Pro Met Ala Glu Tyr Asn Met Pro Gln
        1795                1800                1805            
Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp Ala Arg Asp Gly Gln Ser
    1810                1815                1820                
Arg Thr Val Arg Gln Phe Gln Phe Thr Asp Trp Pro Glu Gln Gly Val
1825                1830                1835                1840
Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile Gly Gln Val His Lys
                1845                1850                1855    
Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile Ser Val His Cys Ser
            1860                1865                1870        
Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr Leu Ser Ile Val Leu
        1875                1880                1885            
Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile Phe Gln Thr Val Lys
    1890                1895                1900                
Met Leu Arg Thr Gln Arg Pro Ala Met Val Gln Thr Glu Asp Glu Tyr
1905                1910                1915                1920
Gln Phe Cys Tyr Gln Ala Ala Leu Glu Tyr Leu Gly Ser Phe Asp His
                1925                1930                1935    
Tyr Ala Thr
            


<210> 9358
<211> 1939
<212> PRT
<213> Homo sapiens

<400> 9358
Met Ala Pro Thr Trp Gly Pro Gly Met Val Ser Val Val Gly Pro Met
 1               5                  10                  15      
Gly Leu Leu Val Val Leu Leu Val Gly Gly Cys Ala Ala Glu Glu Pro
            20                  25                  30          
Pro Arg Phe Ile Lys Glu Pro Lys Asp Gln Ile Gly Val Ser Gly Gly
        35                  40                  45              
Val Ala Ser Phe Val Cys Gln Ala Thr Gly Asp Pro Lys Pro Arg Val
    50                  55                  60                  
Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln Arg Phe Glu Thr
65                  70                  75                  80  
Ile Glu Phe Asp Glu Ser Ala Gly Ala Val Leu Arg Ile Gln Pro Leu
                85                  90                  95      
Arg Thr Pro Arg Asp Glu Asn Val Tyr Glu Cys Val Ala Gln Asn Ser
            100                 105                 110         
Val Gly Glu Ile Thr Val His Ala Lys Leu Thr Val Leu Arg Glu Asp
        115                 120                 125             
Gln Leu Pro Ser Gly Phe Pro Asn Ile Asp Met Gly Pro Gln Leu Lys
    130                 135                 140                 
Val Val Glu Arg Thr Arg Thr Ala Thr Met Leu Cys Ala Ala Ser Gly
145                 150                 155                 160 
Asn Pro Asp Pro Glu Ile Thr Trp Phe Lys Asp Phe Leu Pro Val Asp
                165                 170                 175     
Pro Ser Ala Ser Asn Gly Arg Ile Lys Gln Leu Arg Ser Gly Ala Leu
            180                 185                 190         
Gln Ile Glu Ser Ser Glu Glu Thr Asp Gln Gly Lys Tyr Glu Cys Val
        195                 200                 205             
Ala Thr Asn Ser Ala Gly Val Arg Tyr Ser Ser Pro Ala Asn Leu Tyr
    210                 215                 220                 
Val Arg Glu Leu Arg Glu Val Arg Arg Val Ala Pro Arg Phe Ser Ile
225                 230                 235                 240 
Leu Pro Met Ser His Glu Ile Met Pro Gly Gly Asn Val Asn Ile Thr
                245                 250                 255     
Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Gln Gly
            260                 265                 270         
Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Val Gly Arg Asn Val
        275                 280                 285             
Leu Glu Leu Thr Asp Val Lys Asp Ser Ala Asn Tyr Thr Cys Val Ala
    290                 295                 300                 
Met Ser Ser Leu Gly Val Ile Glu Ala Val Ala Gln Ile Thr Val Lys
305                 310                 315                 320 
Ser Leu Pro Lys Ala Pro Gly Thr Pro Met Val Thr Glu Asn Thr Ala
                325                 330                 335     
Thr Ser Ile Thr Ile Thr Trp Asp Ser Gly Asn Pro Asp Pro Val Ser
            340                 345                 350         
Tyr Tyr Val Ile Glu Tyr Lys Ser Lys Ser Gln Asp Gly Pro Tyr Gln
        355                 360                 365             
Ile Lys Glu Asp Ile Thr Thr Thr Arg Tyr Ser Ile Gly Gly Leu Ser
    370                 375                 380                 
Pro Asn Ser Glu Tyr Glu Ile Trp Val Ser Ala Val Asn Ser Ile Gly
385                 390                 395                 400 
Gln Gly Pro Pro Ser Glu Ser Val Val Thr Arg Thr Gly Glu Gln Ala
                405                 410                 415     
Pro Ala Ser Ala Pro Arg Asn Val Gln Ala Arg Met Leu Ser Ala Thr
            420                 425                 430         
Thr Met Ile Val Gln Trp Glu Glu Pro Val Glu Pro Asn Gly Leu Ile
        435                 440                 445             
Arg Gly Tyr Arg Val Tyr Tyr Thr Met Glu Pro Glu His Pro Val Gly
    450                 455                 460                 
Asn Trp Gln Lys His Asn Val Asp Asp Ser Leu Leu Thr Thr Val Gly
465                 470                 475                 480 
Ser Leu Leu Glu Asp Glu Thr Tyr Thr Val Arg Val Leu Ala Phe Thr
                485                 490                 495     
Ser Val Gly Asp Gly Pro Leu Ser Asp Pro Ile Gln Val Lys Thr Gln
            500                 505                 510         
Gln Gly Val Pro Gly Gln Pro Met Asn Leu Arg Ala Glu Ala Arg Ser
        515                 520                 525             
Glu Thr Ser Ile Thr Leu Ser Trp Ser Pro Pro Arg Gln Glu Ser Ile
    530                 535                 540                 
Ile Lys Tyr Glu Leu Leu Phe Arg Glu Gly Asp His Gly Arg Glu Val
545                 550                 555                 560 
Gly Arg Thr Phe Asp Pro Thr Thr Ser Tyr Val Val Glu Asp Leu Lys
                565                 570                 575     
Pro Asn Thr Glu Tyr Ala Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly
            580                 585                 590         
Leu Gly Ala Phe Thr Pro Val Val Arg Gln Arg Thr Leu Gln Ser Lys
        595                 600                 605             
Pro Ser Ala Pro Pro Gln Asp Val Lys Cys Val Ser Val Arg Ser Thr
    610                 615                 620                 
Ala Ile Leu Val Ser Trp Arg Pro Pro Pro Pro Glu Thr His Asn Gly
625                 630                 635                 640 
Ala Leu Val Gly Tyr Ser Val Arg Tyr Arg Pro Leu Gly Ser Glu Asp
                645                 650                 655     
Pro Glu Pro Lys Glu Val Asn Gly Ile Pro Pro Thr Thr Thr Gln Ile
            660                 665                 670         
Leu Leu Glu Ala Leu Glu Lys Trp Thr Gln Tyr Arg Ile Thr Thr Val
        675                 680                 685             
Ala His Thr Glu Val Gly Pro Gly Pro Glu Ser Ser Pro Val Val Val
    690                 695                 700                 
Arg Thr Asp Glu Asp Val Pro Ser Ala Pro Pro Arg Lys Val Glu Ala
705                 710                 715                 720 
Glu Ala Leu Asn Ala Thr Ala Ile Arg Val Leu Trp Leu Gly Pro Val
                725                 730                 735     
Pro Gly Arg Gln His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val
            740                 745                 750         
Arg Met Glu Gly Ala Glu Gly Arg Gly Pro Pro Arg Ile Lys Asp Val
        755                 760                 765             
Met Leu Ala Asp Ala Gln Trp Glu Thr Asp Asp Thr Ala Glu Tyr Glu
    770                 775                 780                 
Met Val Ile Thr Asn Leu Gln Pro Glu Thr Ala Tyr Ser Ile Thr Val
785                 790                 795                 800 
Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala Arg Ser Lys Pro Lys Val
                805                 810                 815     
Val Val Thr Lys Gly Ala Val Leu Gly Arg Pro Thr Leu Ser Val Gln
            820                 825                 830         
Gln Thr Pro Glu Gly Ser Leu Leu Ala Arg Trp Glu Pro Pro Ala Gly
        835                 840                 845             
Thr Ala Glu Asp Gln Val Leu Gly Tyr Arg Leu Gln Phe Gly Arg Glu
    850                 855                 860                 
Asp Ser Thr Pro Leu Ala Thr Leu Glu Phe Pro Pro Ser Glu Asp Arg
865                 870                 875                 880 
Tyr Thr Ala Ser Gly Val His Lys Gly Ala Thr Tyr Val Phe Arg Leu
                885                 890                 895     
Ala Ala Arg Ser Arg Gly Gly Leu Gly Glu Glu Ala Ala Glu Val Leu
            900                 905                 910         
Ser Ile Pro Glu Asp Thr Pro Arg Gly His Pro Gln Ile Leu Glu Ala
        915                 920                 925             
Ala Gly Asn Ala Ser Ala Gly Thr Val Leu Leu Arg Trp Leu Pro Pro
    930                 935                 940                 
Val Pro Ala Glu Arg Asn Gly Ala Ile Val Lys Tyr Thr Val Ala Val
945                 950                 955                 960 
Arg Glu Ala Gly Ala Leu Gly Pro Ala Arg Glu Thr Glu Leu Pro Ala
                965                 970                 975     
Ala Ala Glu Pro Gly Ala Glu Asn Ala Val Thr Leu Gln Gly Leu Lys
            980                 985                 990         
Pro Asp Thr Ala Tyr Asp Leu Gln Val Arg Ala His Thr Arg Arg Gly
        995                 1000                1005            
Pro Gly Pro Phe Ser Pro Pro Val Arg Tyr Arg Thr Phe Leu Arg Asp
    1010                1015                1020                
Gln Val Ser Pro Lys Asn Phe Lys Val Lys Met Ile Met Lys Thr Ser
1025                1030                1035                1040
Val Leu Leu Ser Trp Glu Phe Pro Asp Asn Tyr Asn Ser Pro Thr Pro
                1045                1050                1055    
Tyr Lys Ile Gln Tyr Asn Gly Leu Thr Leu Asp Val Asp Gly Arg Thr
            1060                1065                1070        
Thr Lys Lys Leu Ile Thr His Leu Lys Pro His Thr Phe Tyr Asn Phe
        1075                1080                1085            
Val Leu Thr Asn Arg Gly Ser Ser Leu Gly Gly Leu Gln Gln Thr Val
    1090                1095                1100                
Thr Ala Trp Thr Ala Phe Asn Leu Leu Asn Gly Lys Pro Ser Val Ala
1105                1110                1115                1120
Pro Lys Pro Asp Ala Asp Gly Phe Ile Met Val Tyr Leu Pro Asp Gly
                1125                1130                1135    
Gln Ser Pro Val Pro Val Gln Ser Tyr Phe Ile Val Met Val Pro Leu
            1140                1145                1150        
Arg Lys Ser Arg Gly Gly Gln Phe Leu Thr Pro Leu Gly Ser Pro Glu
        1155                1160                1165            
Asp Met Asp Leu Glu Glu Leu Ile Gln Asp Ile Ser Arg Leu Gln Arg
    1170                1175                1180                
Arg Thr Val Arg His Ser Arg Gln Leu Glu Val Pro Arg Pro Tyr Ile
1185                1190                1195                1200
Ala Ala Arg Phe Ser Val Leu Pro Pro Thr Phe His Pro Gly Asp Gln
                1205                1210                1215    
Lys Gln Tyr Gly Gly Phe Asp Asn Arg Gly Leu Glu Pro Gly His Arg
            1220                1225                1230        
Tyr Val Leu Phe Val Leu Ala Val Leu Gln Lys Ser Glu Pro Thr Phe
        1235                1240                1245            
Ala Ala Ser Pro Phe Ser Asp Pro Phe Gln Leu Asp Asn Pro Asp Pro
    1250                1255                1260                
Gln Pro Ile Val Asp Gly Glu Glu Gly Leu Ile Trp Val Ile Gly Pro
1265                1270                1275                1280
Val Leu Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu
                1285                1290                1295    
Tyr Lys Asn Lys Pro Asp Ser Lys Arg Lys Asp Ser Glu Pro Arg Thr
            1300                1305                1310        
Lys Cys Leu Leu Asn Asn Ala Asp Leu Ala Pro His His Pro Lys Asp
        1315                1320                1325            
Pro Val Glu Met Arg Arg Ile Asn Phe Gln Thr Pro Asp Ser Gly Leu
    1330                1335                1340                
Arg Ser Pro Leu Arg Glu Pro Gly Phe His Phe Glu Ser Met Leu Ser
1345                1350                1355                1360
His Pro Pro Ile Pro Ile Ala Asp Met Ala Glu His Thr Glu Arg Leu
                1365                1370                1375    
Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr Glu Ser Ile Asp
            1380                1385                1390        
Pro Gly Gln Gln Phe Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys
        1395                1400                1405            
Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr Asp His Phe Arg Val
    1410                1415                1420                
Ile Leu Gln Pro Ile Glu Gly Ile Met Gly Ser Asp Tyr Ile Asn Ala
1425                1430                1435                1440
Asn Tyr Val Asp Gly Tyr Arg Arg Gln Asn Ala Tyr Ile Ala Thr Gln
                1445                1450                1455    
Gly Pro Leu Pro Glu Thr Phe Gly Asp Phe Trp Arg Met Val Trp Glu
            1460                1465                1470        
Gln Arg Ser Ala Thr Ile Val Met Met Thr Arg Leu Glu Glu Lys Ser
        1475                1480                1485            
Arg Ile Lys Cys Asp Gln Tyr Trp Pro Asn Arg Gly Thr Glu Thr Tyr
    1490                1495                1500                
Gly Phe Ile Gln Val Thr Leu Leu Asp Thr Ile Glu Leu Ala Thr Phe
1505                1510                1515                1520
Cys Val Arg Thr Phe Ser Leu His Lys Asn Gly Ser Ser Glu Lys Arg
                1525                1530                1535    
Glu Val Arg Gln Phe Gln Phe Thr Ala Trp Pro Asp His Gly Val Pro
            1540                1545                1550        
Glu Tyr Pro Thr Pro Phe Leu Ala Phe Leu Arg Arg Val Lys Thr Cys
        1555                1560                1565            
Asn Pro Pro Asp Ala Gly Pro Ile Val Val His Cys Ser Ala Gly Val
    1570                1575                1580                
Gly Arg Thr Gly Cys Phe Ile Val Ile Asp Ala Met Leu Glu Arg Ile
1585                1590                1595                1600
Lys Pro Glu Lys Thr Val Asp Val Tyr Gly His Val Thr Leu Met Arg
                1605                1610                1615    
Ser Gln Arg Asn Tyr Met Val Gln Thr Glu Asp Gln Tyr Ser Phe Ile
            1620                1625                1630        
His Glu Ala Leu Leu Glu Ala Val Gly Cys Gly Asn Thr Glu Val Pro
        1635                1640                1645            
Ala Arg Ser Leu Tyr Ala Tyr Ile Gln Lys Leu Ala Gln Val Glu Pro
    1650                1655                1660                
Gly Glu His Val Thr Gly Met Glu Leu Glu Phe Lys Arg Leu Ala Asn
1665                1670                1675                1680
Ser Lys Ala His Thr Ser Arg Phe Ile Ser Ala Asn Leu Pro Cys Asn
                1685                1690                1695    
Lys Phe Lys Asn Arg Leu Val Asn Ile Met Pro Tyr Glu Ser Thr Arg
            1700                1705                1710        
Val Cys Leu Gln Pro Ile Arg Gly Val Glu Gly Ser Asp Tyr Ile Asn
        1715                1720                1725            
Ala Ser Phe Ile Asp Gly Tyr Arg Gln Gln Lys Ala Tyr Ile Ala Thr
    1730                1735                1740                
Gln Gly Pro Leu Ala Glu Thr Thr Glu Asp Phe Trp Arg Met Leu Trp
1745                1750                1755                1760
Glu Asn Asn Ser Thr Ile Val Val Met Leu Thr Lys Leu Arg Glu Met
                1765                1770                1775    
Gly Arg Glu Lys Cys His Gln Tyr Trp Pro Ala Glu Arg Ser Ala Arg
            1780                1785                1790        
Tyr Gln Tyr Phe Val Val Asp Pro Met Ala Glu Tyr Asn Met Pro Gln
        1795                1800                1805            
Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp Ala Arg Asp Gly Gln Ser
    1810                1815                1820                
Arg Thr Val Arg Gln Phe Gln Phe Thr Asp Trp Pro Glu Gln Gly Val
1825                1830                1835                1840
Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile Gly Gln Val His Lys
                1845                1850                1855    
Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile Ser Val His Cys Ser
            1860                1865                1870        
Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr Leu Ser Ile Val Leu
        1875                1880                1885            
Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile Phe Gln Thr Val Lys
    1890                1895                1900                
Met Leu Arg Thr Gln Arg Pro Ala Met Val Gln Thr Glu Asp Glu Tyr
1905                1910                1915                1920
Gln Phe Cys Tyr Gln Ala Ala Leu Glu Tyr Leu Gly Ser Phe Asp His
                1925                1930                1935    
Tyr Ala Thr
            


<210> 9359
<211> 291
<212> PRT
<213> Homo sapiens

<400> 9359
Met Ala Glu Ile Ser Arg Ile Gln Tyr Glu Met Glu Tyr Thr Glu Gly
 1               5                  10                  15      
Ile Ser Gln Arg Met Arg Val Pro Glu Lys Leu Lys Val Ala Pro Pro
            20                  25                  30          
Asn Ala Asp Leu Glu Gln Gly Phe Gln Glu Gly Val Pro Asn Ala Ser
        35                  40                  45              
Val Ile Met Gln Val Pro Glu Arg Ile Val Val Ala Gly Asn Asn Glu
    50                  55                  60                  
Asp Val Ser Phe Ser Arg Pro Ala Asp Leu Asp Leu Ile Gln Ser Thr
65                  70                  75                  80  
Pro Phe Lys Pro Leu Ala Leu Lys Thr Pro Pro Arg Val Leu Thr Leu
                85                  90                  95      
Ser Glu Arg Pro Leu Asp Phe Leu Asp Leu Glu Arg Pro Pro Thr Thr
            100                 105                 110         
Pro Gln Asn Glu Glu Ile Arg Ala Val Gly Arg Leu Lys Arg Glu Arg
        115                 120                 125             
Ser Met Ser Glu Asn Ala Val Arg Gln Asn Gly Gln Leu Val Arg Asn
    130                 135                 140                 
Asp Ser Leu Val Thr Pro Ser Pro Gln Gln Ala Arg Val Cys Pro Pro
145                 150                 155                 160 
His Met Leu Pro Glu Asp Gly Ala Asn Leu Ser Ser Ala Arg Gly Ile
                165                 170                 175     
Leu Ser Leu Ile Gln Ser Ser Thr Arg Arg Ala Tyr Gln Gln Ile Leu
            180                 185                 190         
Asp Val Leu Asp Glu Asn Arg Arg Pro Val Leu Arg Gly Gly Ser Ala
        195                 200                 205             
Ala Ala Thr Ser Asn Pro His His Asp Asn Val Arg Tyr Gly Ile Ser
    210                 215                 220                 
Asn Ile Asp Thr Thr Ile Glu Gly Thr Ser Asp Asp Leu Thr Val Val
225                 230                 235                 240 
Asp Ala Ala Ser Leu Arg Arg Gln Ile Ile Lys Leu Asn Arg Arg Leu
                245                 250                 255     
Gln Leu Leu Glu Glu Glu Asn Lys Glu Arg Ala Lys Arg Glu Met Val
            260                 265                 270         
Met Tyr Ser Ile Thr Val Ala Phe Trp Leu Leu Asn Ser Trp Leu Trp
        275                 280                 285             
Phe Arg Arg
    290     


<210> 9360
<211> 342
<212> PRT
<213> Homo sapiens

<400> 9360
Met Ser Lys Gly Thr Ser Ser Asp Thr Ser Leu Gly Arg Val Ser Arg
 1               5                  10                  15      
Ala Ala Phe Pro Ser Pro Thr Ala Ala Glu Met Ala Glu Ile Ser Arg
            20                  25                  30          
Ile Gln Tyr Glu Met Glu Tyr Thr Glu Gly Ile Ser Gln Arg Met Arg
        35                  40                  45              
Val Pro Glu Lys Leu Lys Val Ala Pro Pro Asn Ala Asp Leu Glu Gln
    50                  55                  60                  
Gly Phe Gln Glu Gly Val Pro Asn Ala Ser Val Ile Met Gln Val Pro
65                  70                  75                  80  
Glu Arg Ile Val Val Ala Gly Asn Asn Glu Asp Val Ser Phe Ser Arg
                85                  90                  95      
Pro Ala Asp Leu Asp Leu Ile Gln Ser Thr Pro Phe Lys Pro Leu Ala
            100                 105                 110         
Leu Lys Thr Pro Pro Arg Val Leu Thr Leu Ser Glu Arg Pro Leu Asp
        115                 120                 125             
Phe Leu Asp Leu Glu Arg Pro Pro Thr Thr Pro Gln Asn Glu Glu Ile
    130                 135                 140                 
Arg Ala Val Gly Arg Leu Lys Arg Glu Arg Ser Met Ser Glu Asn Ala
145                 150                 155                 160 
Val Arg Gln Asn Gly Gln Leu Val Arg Asn Asp Ser Leu Trp His Arg
                165                 170                 175     
Ser Asp Ser Ala Pro Arg Asn Lys Ile Ser Arg Phe Gln Ala Pro Ile
            180                 185                 190         
Ser Ala Pro Glu Tyr Thr Val Thr Pro Ser Pro Gln Gln Ala Arg Val
        195                 200                 205             
Cys Pro Pro His Met Leu Pro Glu Asp Gly Ala Asn Leu Ser Ser Ala
    210                 215                 220                 
Arg Gly Ile Leu Ser Leu Ile Gln Ser Ser Thr Arg Arg Ala Tyr Gln
225                 230                 235                 240 
Gln Ile Leu Asp Val Leu Asp Glu Asn Arg Arg Pro Val Leu Arg Gly
                245                 250                 255     
Gly Ser Ala Ala Ala Thr Ser Asn Pro His His Asp Asn Val Arg Tyr
            260                 265                 270         
Gly Ile Ser Asn Ile Asp Thr Thr Ile Glu Gly Thr Ser Asp Asp Leu
        275                 280                 285             
Thr Val Val Asp Ala Ala Ser Leu Arg Arg Gln Ile Ile Lys Leu Asn
    290                 295                 300                 
Arg Arg Leu Gln Leu Leu Glu Glu Glu Asn Lys Glu Arg Ala Lys Arg
305                 310                 315                 320 
Glu Met Val Met Tyr Ser Ile Thr Val Ala Phe Trp Leu Leu Asn Ser
                325                 330                 335     
Trp Leu Trp Phe Arg Arg
            340         


<210> 9361
<211> 311
<212> PRT
<213> Homo sapiens

<400> 9361
Met Ala Gly Val Gly Leu Ser Phe Leu Phe Ala Ala Pro Leu Ile Leu
 1               5                  10                  15      
Leu Val Phe Ala Thr Phe Leu Val Gly Gly Asn Val Gln Thr Leu Val
            20                  25                  30          
Cys Gln Ser Trp Glu Asn Ser Glu Leu Phe Glu Phe Ala Asp Thr Pro
        35                  40                  45              
Gly Asn Leu Pro Pro Ser Met Asn Leu Ser Gln Leu Leu Gly Leu Arg
    50                  55                  60                  
Lys Asn Ile Ser Ile His Gln Ala Tyr Gln Gln Cys Lys Glu Gly Ala
65                  70                  75                  80  
Ala Leu Trp Thr Val Leu Gln Leu Asn Asp Ser Tyr Asp Leu Glu Glu
                85                  90                  95      
His Leu Asp Ile Asn Gln Ile Gln Arg Pro Val Val Lys Thr Ser Met
            100                 105                 110         
Glu Gln Leu Ala Gln Glu Leu Gln Gly Leu Ala Gln Ala Gln Asp Asn
        115                 120                 125             
Ser Val Leu Gly Gln Arg Leu Gln Glu Glu Ala Gln Gly Leu Arg Asn
    130                 135                 140                 
Leu His Gln Glu Lys Val Val Pro Gln Gln Ser Leu Val Ala Lys Leu
145                 150                 155                 160 
Asn Leu Ser Val Arg Ala Leu Glu Ser Ser Ala Pro Asn Leu Gln Leu
                165                 170                 175     
Glu Ala Ser Asp Ile Leu Ala Asn Val Thr Tyr Leu Lys Gly Glu Leu
            180                 185                 190         
Pro Ala Trp Ala Ala Arg Ile Leu Arg Asn Val Ser Glu Cys Phe Leu
        195                 200                 205             
Ala Arg Glu Met Gly Tyr Phe Ser Gln Tyr Val Ala Trp Val Arg Glu
    210                 215                 220                 
Glu Val Thr Gln Arg Ile Ala Thr Cys Gln Pro Leu Ser Gly Ala Leu
225                 230                 235                 240 
Asp Asn Ser Arg Val Ile Leu Cys Asp Met Met Ala Asp Pro Trp Asn
                245                 250                 255     
Ala Phe Trp Phe Cys Leu Ala Trp Cys Thr Phe Phe Leu Ile Pro Ser
            260                 265                 270         
Ile Ile Phe Ala Val Lys Thr Ser Lys Tyr Phe Arg Pro Ile Arg Lys
        275                 280                 285             
Arg Leu Ser Ser Thr Ser Ser Glu Glu Thr Gln Leu Phe His Ile Pro
    290                 295                 300                 
Arg Val Thr Ser Leu Lys Leu
305                 310     


<210> 9362
<211> 834
<212> PRT
<213> Homo sapiens

<400> 9362
Met Lys His Thr Leu Ala Leu Leu Ala Pro Leu Leu Gly Leu Gly Leu
 1               5                  10                  15      
Gly Leu Ala Leu Ser Gln Leu Ala Ala Gly Ala Thr Asp Cys Lys Phe
            20                  25                  30          
Leu Gly Pro Ala Glu His Leu Thr Phe Thr Pro Ala Ala Arg Ala Arg
        35                  40                  45              
Trp Leu Ala Pro Arg Val Arg Ala Pro Gly Leu Leu Asp Ser Leu Tyr
    50                  55                  60                  
Gly Thr Val Arg Arg Phe Leu Ser Val Val Gln Leu Asn Pro Phe Pro
65                  70                  75                  80  
Ser Glu Leu Val Lys Ala Leu Leu Asn Glu Leu Ala Ser Val Lys Val
                85                  90                  95      
Asn Glu Val Val Arg Tyr Glu Ala Gly Tyr Val Val Cys Ala Val Ile
            100                 105                 110         
Ala Gly Leu Tyr Leu Leu Leu Val Pro Thr Ala Gly Leu Cys Phe Cys
        115                 120                 125             
Cys Cys Arg Cys His Arg Arg Cys Gly Gly Arg Val Lys Thr Glu His
    130                 135                 140                 
Lys Ala Leu Ala Cys Glu Arg Ala Ala Leu Met Val Phe Leu Leu Leu
145                 150                 155                 160 
Thr Thr Leu Leu Leu Leu Ile Gly Val Val Cys Ala Phe Val Thr Asn
                165                 170                 175     
Gln Arg Thr His Glu Gln Met Gly Pro Ser Ile Glu Ala Met Pro Glu
            180                 185                 190         
Thr Leu Leu Ser Leu Trp Gly Leu Val Ser Asp Val Pro Gln Glu Leu
        195                 200                 205             
Gln Ala Val Ala Gln Gln Phe Ser Leu Pro Gln Glu Gln Val Ser Glu
    210                 215                 220                 
Glu Leu Asp Gly Val Gly Val Ser Ile Gly Ser Ala Ile His Thr Gln
225                 230                 235                 240 
Leu Arg Ser Ser Val Tyr Pro Leu Leu Ala Ala Val Gly Ser Leu Gly
                245                 250                 255     
Gln Val Leu Gln Val Ser Val His His Leu Gln Thr Leu Asn Ala Thr
            260                 265                 270         
Val Val Glu Leu Gln Ala Gly Gln Gln Asp Leu Glu Pro Ala Ile Arg
        275                 280                 285             
Glu His Arg Asp Arg Leu Leu Glu Leu Leu Gln Glu Ala Arg Cys Gln
    290                 295                 300                 
Gly Asp Cys Ala Gly Ala Leu Ser Trp Ala Arg Thr Leu Glu Leu Gly
305                 310                 315                 320 
Ala Asp Phe Ser Gln Val Pro Ser Val Asp His Val Leu His Gln Leu
                325                 330                 335     
Lys Gly Val Pro Glu Ala Asn Phe Ser Ser Met Val Gln Glu Glu Asn
            340                 345                 350         
Ser Thr Phe Asn Ala Leu Pro Ala Leu Ala Ala Met Gln Thr Ser Ser
        355                 360                 365             
Val Val Gln Glu Leu Lys Lys Ala Val Ala Gln Gln Pro Glu Gly Val
    370                 375                 380                 
Arg Thr Leu Ala Glu Gly Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp
385                 390                 395                 400 
Ala Gln Ala Leu Gln Glu Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln
                405                 410                 415     
Glu Val Gln Arg Tyr Glu Thr Tyr Arg Trp Ile Val Gly Cys Val Leu
            420                 425                 430         
Cys Ser Val Val Leu Phe Val Val Leu Cys Asn Leu Leu Gly Leu Asn
        435                 440                 445             
Leu Gly Ile Trp Gly Leu Ser Ala Arg Asp Asp Pro Ser His Pro Glu
    450                 455                 460                 
Ala Lys Gly Glu Ala Gly Ala Arg Phe Leu Met Ala Gly Val Gly Leu
465                 470                 475                 480 
Ser Phe Leu Phe Ala Ala Pro Leu Ile Leu Leu Val Phe Ala Thr Phe
                485                 490                 495     
Leu Val Gly Gly Asn Val Gln Thr Leu Val Cys Gln Ser Trp Glu Asn
            500                 505                 510         
Gly Glu Leu Phe Glu Phe Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser
        515                 520                 525             
Met Asn Leu Ser Gln Leu Leu Gly Leu Arg Lys Asn Ile Ser Ile His
    530                 535                 540                 
Gln Ala Tyr Gln Gln Cys Lys Glu Gly Ala Ala Leu Trp Thr Val Leu
545                 550                 555                 560 
Gln Leu Asn Asp Ser Tyr Asp Leu Glu Glu His Leu Asp Ile Asn Gln
                565                 570                 575     
Tyr Thr Asn Lys Leu Arg Gln Glu Leu Gln Ser Leu Lys Val Asp Thr
            580                 585                 590         
Gln Ser Leu Asp Leu Leu Ser Ser Ala Ala Arg Arg Asp Leu Glu Ala
        595                 600                 605             
Leu Gln Ser Ser Gly Leu Gln Arg Ile His Tyr Pro Asp Phe Leu Val
    610                 615                 620                 
Gln Ile Gln Arg Pro Val Val Lys Thr Ser Met Glu Gln Leu Ala Gln
625                 630                 635                 640 
Glu Leu Gln Gly Leu Ala Gln Ala Gln Asp Asn Ser Val Leu Gly Gln
                645                 650                 655     
Arg Leu Gln Glu Glu Ala Gln Gly Leu Arg Asn Leu His Gln Glu Lys
            660                 665                 670         
Val Val Pro Gln Gln Ser Leu Val Ala Lys Leu Asn Leu Ser Val Arg
        675                 680                 685             
Ala Leu Glu Ser Ser Ala Pro Asn Leu Gln Leu Glu Thr Ser Asp Val
    690                 695                 700                 
Leu Ala Asn Val Thr Tyr Leu Lys Gly Glu Leu Pro Ala Trp Ala Ala
705                 710                 715                 720 
Arg Ile Leu Arg Asn Val Ser Glu Cys Phe Leu Ala Arg Glu Met Gly
                725                 730                 735     
Tyr Phe Ser Gln Tyr Val Ala Trp Val Arg Glu Glu Val Thr Gln Arg
            740                 745                 750         
Ile Ala Thr Cys Gln Pro Leu Ser Gly Ala Leu Asp Asn Ser Arg Val
        755                 760                 765             
Ile Leu Cys Asp Met Met Ala Asp Pro Trp Asn Ala Phe Trp Phe Cys
    770                 775                 780                 
Leu Ala Trp Cys Thr Phe Phe Leu Ile Pro Ser Ile Ile Phe Ala Val
785                 790                 795                 800 
Lys Thr Ser Lys Tyr Phe Arg Pro Ile Arg Lys Arg Leu Ser Ser Thr
                805                 810                 815     
Ser Ser Glu Glu Thr Gln Leu Phe His Ile Pro Arg Val Thr Ser Leu
            820                 825                 830         
Lys Leu
        


<210> 9363
<211> 479
<212> PRT
<213> Homo sapiens

<400> 9363
Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu
 1               5                  10                  15      
Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser
            20                  25                  30          
Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu
        35                  40                  45              
Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro
    50                  55                  60                  
Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu
65                  70                  75                  80  
Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile
                85                  90                  95      
Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu
            100                 105                 110         
Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu
        115                 120                 125             
Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile
    130                 135                 140                 
Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala
145                 150                 155                 160 
Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile
                165                 170                 175     
Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val
            180                 185                 190         
Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu
        195                 200                 205             
Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn
    210                 215                 220                 
Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr
225                 230                 235                 240 
Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu
                245                 250                 255     
Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys
            260                 265                 270         
His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala
        275                 280                 285             
Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn
    290                 295                 300                 
Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys
305                 310                 315                 320 
Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe
                325                 330                 335     
Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe
            340                 345                 350         
Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr
        355                 360                 365             
Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr
    370                 375                 380                 
Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln
385                 390                 395                 400 
Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His
                405                 410                 415     
Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu
            420                 425                 430         
Arg Ala Cys Thr Arg Arg Val Leu Leu Arg Pro Glu Lys Arg Pro Pro
        435                 440                 445             
Val Ser Val Trp Val Leu Gln Ser Pro Asp His His Asn Trp Leu Ala
    450                 455                 460                 
Asp Lys Met Leu Thr Thr Val Glu Lys Lys Val Met Ile His Asp
465                 470                 475                 


<210> 9364
<211> 445
<212> PRT
<213> Homo sapiens

<400> 9364
Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu
 1               5                  10                  15      
Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser
            20                  25                  30          
Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu
        35                  40                  45              
Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro
    50                  55                  60                  
Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu
65                  70                  75                  80  
Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile
                85                  90                  95      
Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu
            100                 105                 110         
Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu
        115                 120                 125             
Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile
    130                 135                 140                 
Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala
145                 150                 155                 160 
Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile
                165                 170                 175     
Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val
            180                 185                 190         
Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu
        195                 200                 205             
Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn
    210                 215                 220                 
Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr
225                 230                 235                 240 
Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu
                245                 250                 255     
Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys
            260                 265                 270         
His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala
        275                 280                 285             
Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn
    290                 295                 300                 
Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys
305                 310                 315                 320 
Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe
                325                 330                 335     
Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe
            340                 345                 350         
Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr
        355                 360                 365             
Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr
    370                 375                 380                 
Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln
385                 390                 395                 400 
Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His
                405                 410                 415     
Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu
            420                 425                 430         
Gln Asn Ala Asp Tyr Cys Arg Lys Lys Gly His Asp Ser
        435                 440                 445 


<210> 9365
<211> 432
<212> PRT
<213> Homo sapiens

<400> 9365
Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu
 1               5                  10                  15      
Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser
            20                  25                  30          
Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu
        35                  40                  45              
Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro
    50                  55                  60                  
Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu
65                  70                  75                  80  
Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile
                85                  90                  95      
Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu
            100                 105                 110         
Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu
        115                 120                 125             
Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile
    130                 135                 140                 
Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala
145                 150                 155                 160 
Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile
                165                 170                 175     
Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val
            180                 185                 190         
Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu
        195                 200                 205             
Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn
    210                 215                 220                 
Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr
225                 230                 235                 240 
Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu
                245                 250                 255     
Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys
            260                 265                 270         
His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala
        275                 280                 285             
Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn
    290                 295                 300                 
Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys
305                 310                 315                 320 
Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe
                325                 330                 335     
Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe
            340                 345                 350         
Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr
        355                 360                 365             
Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr
    370                 375                 380                 
Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln
385                 390                 395                 400 
Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His
                405                 410                 415     
Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu
            420                 425                 430         


<210> 9366
<211> 369
<212> PRT
<213> Homo sapiens

<400> 9366
Met Ala Ala Val Ala Pro Ala Gly Pro Gly Asp Ser Ala Ser Ala Ala
 1               5                  10                  15      
Leu Asp Glu Leu Ser Leu Asn Phe Thr Tyr Gly Ala Pro Gly Ala Gly
            20                  25                  30          
Asn Gly Ser Leu Ser Gly Asp Trp Tyr Arg Arg Asn Gln Ile His Leu
        35                  40                  45              
Phe Gly Val Leu Leu Ala Ile Leu Gly Asn Leu Val Ile Ser Ile Ser
    50                  55                  60                  
Leu Asn Ile Gln Lys Tyr Ser His Leu Gln Leu Ala Gln Gln Glu His
65                  70                  75                  80  
Pro Arg Pro Tyr Phe Lys Ser Val Leu Trp Trp Gly Gly Val Leu Leu
                85                  90                  95      
Met Ala Val Gly Glu Thr Gly Asn Phe Ala Ala Tyr Gly Phe Ala Pro
            100                 105                 110         
Ile Thr Leu Ile Ala Pro Leu Gly Cys Val Ser Val Thr Gly Ser Ala
        115                 120                 125             
Ile Ile Ser Val Thr Phe Leu Lys Asp Asn Leu Arg Ala Ser Asp Leu
    130                 135                 140                 
Leu Gly Thr Thr Leu Ala Phe Ala Gly Thr Tyr Leu Leu Val Asn Phe
145                 150                 155                 160 
Ala Pro Asn Ile Thr Gln Ala Ile Ser Ala Arg Thr Val Gln Tyr Tyr
                165                 170                 175     
Leu Val Gly Trp Gln Phe Leu Ile Tyr Val Ile Leu Glu Ile Leu Ile
            180                 185                 190         
Phe Cys Ile Leu Leu Tyr Phe Tyr Lys Arg Lys Gly Met Lys His Met
        195                 200                 205             
Val Ile Leu Leu Thr Leu Val Ala Ile Leu Ala Ser Leu Thr Val Ile
    210                 215                 220                 
Ser Val Lys Ala Val Ser Gly Met Ile Thr Phe Ser Val Met Asp Lys
225                 230                 235                 240 
Met Gln Leu Thr Tyr Pro Ile Phe Tyr Ile Met Phe Ile Ile Met Ile
                245                 250                 255     
Ala Ser Cys Val Phe Gln Val Lys Phe Leu Asn Gln Ala Thr Lys Leu
            260                 265                 270         
Tyr Asn Thr Thr Thr Val Val Pro Val Asn His Ile Phe Phe Thr Ile
        275                 280                 285             
Ser Ala Ile Ile Ala Gly Ile Ile Phe Tyr Gln Glu Phe Leu Gly Ala
    290                 295                 300                 
Pro Phe Leu Thr Val Phe Ile Tyr Leu Phe Gly Cys Phe Leu Ser Phe
305                 310                 315                 320 
Leu Gly Val Phe Leu Val Thr Arg Asn Arg Glu Lys Glu His Leu Gln
                325                 330                 335     
Gln Ser Tyr Ile Asp Phe Gly Asn Ile Pro Glu Asp Thr Thr Pro Glu
            340                 345                 350         
Arg Lys Ala Trp Arg Glu Thr Asn Val Gly Gln Asn Thr Thr Arg Phe
        355                 360                 365             
Thr
    


<210> 9367
<211> 460
<212> PRT
<213> Homo sapiens

<400> 9367
Met Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu
 1               5                  10                  15      
Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Thr Thr
            20                  25                  30          
Gly Leu Leu Ser Leu Ala Thr Val Thr Gly Asn Leu Leu Val Leu Ile
        35                  40                  45              
Ser Phe Lys Val Asn Thr Glu Leu Lys Thr Val Asn Asn Tyr Phe Leu
    50                  55                  60                  
Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Thr Phe Ser Met Asn
65                  70                  75                  80  
Leu Tyr Thr Thr Tyr Leu Leu Met Gly His Trp Ala Leu Gly Thr Leu
                85                  90                  95      
Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser
            100                 105                 110         
Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Thr
        115                 120                 125             
Arg Pro Leu Ser Tyr Arg Ala Lys Arg Thr Pro Arg Arg Ala Ala Leu
    130                 135                 140                 
Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala
145                 150                 155                 160 
Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Thr Val Leu Ala Gly
                165                 170                 175     
Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Thr Phe Gly Thr
            180                 185                 190         
Ala Met Ala Ala Phe Tyr Leu Pro Val Thr Val Met Cys Thr Leu Tyr
        195                 200                 205             
Trp Arg Ile Tyr Arg Glu Thr Glu Asn Arg Ala Arg Glu Leu Ala Ala
    210                 215                 220                 
Leu Gln Gly Ser Glu Thr Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser
225                 230                 235                 240 
Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Thr Pro Pro
                245                 250                 255     
Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr
            260                 265                 270         
Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu
        275                 280                 285             
Thr Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met
    290                 295                 300                 
Pro Met Val Asp Pro Glu Ala Gln Ala Pro Thr Lys Gln Pro Pro Arg
305                 310                 315                 320 
Ser Ser Pro Asn Thr Val Lys Arg Pro Thr Lys Lys Gly Arg Asp Arg
                325                 330                 335     
Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg
            340                 345                 350         
Lys Thr Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Thr Leu Ser
        355                 360                 365             
Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr Asn Ile Met
    370                 375                 380                 
Val Leu Val Ser Thr Phe Cys Lys Asp Cys Val Pro Glu Thr Leu Trp
385                 390                 395                 400 
Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Met
                405                 410                 415     
Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Thr Phe Arg Leu Leu
            420                 425                 430         
Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg
        435                 440                 445             
Pro Gly Ser Val His Arg Thr Pro Ser Arg Gln Cys
    450                 455                 460 


<210> 9368
<211> 1283
<212> PRT
<213> Homo sapiens

<400> 9368
Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly Leu
 1               5                  10                  15      
Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr Ile
            20                  25                  30          
Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg Asp
        35                  40                  45              
Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met Asp
    50                  55                  60                  
Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn His
65                  70                  75                  80  
Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His Cys
                85                  90                  95      
Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly Ser
            100                 105                 110         
Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu Asp
        115                 120                 125             
Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu Gln
    130                 135                 140                 
His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn Asn
145                 150                 155                 160 
Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly Val
                165                 170                 175     
Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val Gly
            180                 185                 190         
Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln Tyr
        195                 200                 205             
Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile Thr
    210                 215                 220                 
Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His Pro
225                 230                 235                 240 
Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu Leu
                245                 250                 255     
His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln Cys
            260                 265                 270         
Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu Asp
        275                 280                 285             
His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln Lys
    290                 295                 300                 
Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val Ala
305                 310                 315                 320 
Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val Glu
                325                 330                 335     
Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu Val
            340                 345                 350         
Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala Asp
        355                 360                 365             
Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn Pro
    370                 375                 380                 
Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr His
385                 390                 395                 400 
Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala Asp
                405                 410                 415     
Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile Val
            420                 425                 430         
Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu Ile
        435                 440                 445             
Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu Arg
    450                 455                 460                 
Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn Ser
465                 470                 475                 480 
Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu Glu
                485                 490                 495     
Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser Glu
            500                 505                 510         
Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu Lys
        515                 520                 525             
Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln Lys
    530                 535                 540                 
Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr Ile
545                 550                 555                 560 
Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu Ser
                565                 570                 575     
Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile Gly
            580                 585                 590         
Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly Ile
        595                 600                 605             
Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His Gln
    610                 615                 620                 
Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala Ala
625                 630                 635                 640 
Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr Ser
                645                 650                 655     
His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr Val
            660                 665                 670         
Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr Gly
        675                 680                 685             
Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln Pro
    690                 695                 700                 
Asp Glu Asn Ile Trp Gln Val Pro Arg Arg Ala Glu Gly Gly Gly Met
705                 710                 715                 720 
Asn Val Gly Ile Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn
                725                 730                 735     
Ser Phe Glu Gln Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr
            740                 745                 750         
Tyr Phe Asn Gln His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn
        755                 760                 765             
Glu Gly Ile Asp Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu
    770                 775                 780                 
Leu Asp Met Phe Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp
785                 790                 795                 800 
Glu Glu Ser Arg Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys
                805                 810                 815     
Phe Glu Asp Asn Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val
            820                 825                 830         
Glu Leu Cys Phe Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp
        835                 840                 845             
Ala Ser Gly Val Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val
    850                 855                 860                 
Val Val Val Leu Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe
865                 870                 875                 880 
Ser Ile Pro Leu Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg
                885                 890                 895     
Ile Thr Val Ala Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys
            900                 905                 910         
Ala Lys Val Asp Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr
        915                 920                 925             
Asn Met Lys Arg Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met
    930                 935                 940                 
Asp Leu Leu Ser Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys
945                 950                 955                 960 
Ile Lys Pro Asn Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg
                965                 970                 975     
Val Leu Ala Gln Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile
            980                 985                 990         
Arg Arg Gln Gly Tyr Ser His Arg Ile Leu Phe Glu Glu Phe Val Lys
        995                 1000                1005            
Arg Tyr Tyr Tyr Leu Ala Phe Thr Ala His Gln Thr Pro Leu Ala Ser
    1010                1015                1020                
Lys Glu Ser Cys Val Ala Ile Leu Glu Lys Ser Arg Leu Asp His Trp
1025                1030                1035                1040
Val Leu Gly Lys Thr Lys Val Phe Leu Lys Tyr Tyr His Val Glu Gln
                1045                1050                1055    
Leu Asn Leu Leu Leu Arg Glu Val Ile Gly Arg Val Val Val Leu Gln
            1060                1065                1070        
Ala Tyr Thr Lys Gly Trp Leu Gly Ala Arg Arg Tyr Lys Arg Val Arg
        1075                1080                1085            
Glu Lys Arg Glu Lys Gly Ala Ile Ala Ile Gln Ser Ala Trp Arg Gly
    1090                1095                1100                
Tyr Asp Ala Arg Arg Lys Phe Lys Lys Ile Ser Asn Arg Arg Asn Glu
1105                1110                1115                1120
Ser Ala Ala His Asn Gln Ala Gly Asp Thr Ser Asn Gln Ser Ser Gly
                1125                1130                1135    
Pro His Ser Pro Val Ala Ala Gly Thr Arg Gly Ser Ala Glu Val Gln
            1140                1145                1150        
Asp Cys Ser Glu Pro Gly Asp His Lys Val Leu Arg Gly Ser Val His
        1155                1160                1165            
Arg Arg Ser His Ser Gln Ala Glu Ser Asn Asn Gly Arg Thr Gln Thr
    1170                1175                1180                
Ser Ser Asn Ser Pro Ala Val Thr Glu Lys Asn Gly Trp Ser Phe Thr
1185                1190                1195                1200
Leu Leu Leu Arg Leu Glu Cys Asn Ser Met Ile Ser Ala Asp Cys Asn
                1205                1210                1215    
Leu Arg Pro Leu Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val
            1220                1225                1230        
Ala Gly Ile Thr Glu Glu His Pro Arg Gln Glu Lys Gln Glu Trp Ala
        1235                1240                1245            
Ile Ala Arg Gly Arg Ile Cys Arg Ala Ile Leu Gly Ser Thr Arg Phe
    1250                1255                1260                
Leu Gly Leu Ile Cys Cys Leu Leu Gly Tyr Ala Ile Leu Leu Gln Ile
1265                1270                1275                1280
Ser Lys Asp
            


<210> 9369
<211> 1345
<212> PRT
<213> Homo sapiens

<400> 9369
Lys His Leu Tyr Gly Leu Phe His Tyr Asn Pro Met Met Leu Gly Leu
 1               5                  10                  15      
Glu Ser Leu Pro Asp Pro Thr Asp Thr Trp Glu Ile Ile Glu Thr Ile
            20                  25                  30          
Gly Lys Gly Thr Tyr Gly Lys Val Tyr Lys Val Thr Asn Lys Arg Asp
        35                  40                  45              
Gly Ser Leu Ala Ala Val Lys Ile Leu Asp Pro Val Ser Asp Met Asp
    50                  55                  60                  
Glu Glu Ile Glu Ala Glu Tyr Asn Ile Leu Gln Phe Leu Pro Asn His
65                  70                  75                  80  
Pro Asn Val Val Lys Phe Tyr Gly Met Phe Tyr Lys Ala Asp His Cys
                85                  90                  95      
Val Gly Gly Gln Leu Trp Leu Val Leu Glu Leu Cys Asn Gly Gly Ser
            100                 105                 110         
Val Thr Glu Leu Val Lys Gly Leu Leu Arg Cys Gly Gln Arg Leu Asp
        115                 120                 125             
Glu Ala Met Ile Ser Tyr Ile Leu Tyr Gly Ala Leu Leu Gly Leu Gln
    130                 135                 140                 
His Leu His Asn Asn Arg Ile Ile His Arg Asp Val Lys Gly Asn Asn
145                 150                 155                 160 
Ile Leu Leu Thr Thr Glu Gly Gly Val Lys Leu Val Asp Phe Gly Val
                165                 170                 175     
Ser Ala Gln Leu Thr Ser Thr Arg Leu Arg Arg Asn Thr Ser Val Gly
            180                 185                 190         
Thr Pro Phe Trp Met Ala Pro Glu Val Ile Ala Cys Glu Gln Gln Tyr
        195                 200                 205             
Asp Ser Ser Tyr Asp Ala Arg Cys Asp Val Trp Ser Leu Gly Ile Thr
    210                 215                 220                 
Ala Ile Glu Leu Gly Asp Gly Asp Pro Pro Leu Phe Asp Met His Pro
225                 230                 235                 240 
Val Lys Thr Leu Phe Lys Ile Pro Arg Asn Pro Pro Pro Thr Leu Leu
                245                 250                 255     
His Pro Glu Lys Trp Cys Glu Glu Phe Asn His Phe Ile Ser Gln Cys
            260                 265                 270         
Leu Ile Lys Asp Phe Glu Arg Arg Pro Ser Val Thr His Leu Leu Asp
        275                 280                 285             
His Pro Phe Ile Lys Gly Val His Gly Lys Val Leu Phe Leu Gln Lys
    290                 295                 300                 
Gln Leu Ala Lys Val Leu Gln Asp Gln Lys His Gln Asn Pro Val Ala
305                 310                 315                 320 
Lys Thr Arg His Glu Arg Met His Thr Arg Arg Pro Tyr His Val Glu
                325                 330                 335     
Asp Ala Glu Lys Tyr Cys Leu Glu Asp Asp Leu Val Asn Leu Glu Val
            340                 345                 350         
Leu Asp Glu Asp Thr Ile Ile His Gln Leu Gln Lys Arg Tyr Ala Asp
        355                 360                 365             
Leu Leu Ile Tyr Thr Tyr Val Gly Asp Ile Leu Ile Ala Leu Asn Pro
    370                 375                 380                 
Phe Gln Asn Leu Ser Ile Tyr Ser Pro Gln Phe Ser Arg Leu Tyr His
385                 390                 395                 400 
Gly Val Lys Arg Ala Ser Asn Pro Pro His Ile Phe Ala Ser Ala Asp
                405                 410                 415     
Ala Ala Tyr Gln Cys Met Val Thr Leu Ser Lys Asp Gln Cys Ile Val
            420                 425                 430         
Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ser Ala His Leu Ile
        435                 440                 445             
Val Gln His Leu Thr Phe Leu Gly Lys Ala Asn Asn Gln Thr Leu Arg
    450                 455                 460                 
Glu Lys Ile Leu Gln Val Asn Ser Leu Val Glu Ala Phe Gly Asn Ser
465                 470                 475                 480 
Cys Thr Ala Ile Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Leu Glu
                485                 490                 495     
Met Met Phe Thr Pro Thr Gly Val Val Met Gly Ala Arg Ile Ser Glu
            500                 505                 510         
Tyr Leu Leu Glu Lys Ser Arg Val Ile Lys Gln Ala Ala Arg Glu Lys
        515                 520                 525             
Asn Phe His Ile Phe Tyr Tyr Ile Tyr Ala Gly Leu His His Gln Lys
    530                 535                 540                 
Lys Leu Ser Asp Phe Arg Leu Pro Glu Glu Lys Pro Pro Arg Tyr Ile
545                 550                 555                 560 
Ala Asp Glu Thr Gly Arg Val Met His Asp Ile Thr Ser Lys Glu Ser
                565                 570                 575     
Tyr Arg Arg Gln Phe Glu Ala Ile Gln His Cys Phe Arg Ile Ile Gly
            580                 585                 590         
Phe Thr Asp Lys Glu Val His Ser Val Tyr Arg Ile Leu Ala Gly Ile
        595                 600                 605             
Leu Asn Ile Gly Asn Ile Glu Phe Ala Ala Ile Ser Ser Gln His Gln
    610                 615                 620                 
Thr Asp Lys Ser Glu Val Pro Asn Ala Glu Ala Leu Gln Asn Ala Ala
625                 630                 635                 640 
Ser Val Leu Cys Ile Ser Pro Glu Glu Leu Gln Glu Ala Leu Thr Ser
                645                 650                 655     
His Cys Val Val Thr Arg Gly Glu Thr Ile Ile Arg Ala Asn Thr Val
            660                 665                 670         
Asp Arg Ala Ala Asp Val Arg Asp Ala Met Ser Lys Ala Leu Tyr Gly
        675                 680                 685             
Arg Leu Phe Ser Trp Ile Val Asn Arg Ile Asn Thr Leu Leu Gln Pro
    690                 695                 700                 
Asp Glu Asn Ile Trp Gln Val Pro Arg Arg Ala Glu Gly Gly Gly Met
705                 710                 715                 720 
Asn Val Gly Ile Leu Asp Ile Phe Gly Phe Glu Asn Phe Gln Arg Asn
                725                 730                 735     
Ser Phe Glu Gln Leu Cys Ile Asn Ile Ala Asn Glu Gln Ile Gln Tyr
            740                 745                 750         
Tyr Phe Asn Gln His Val Phe Ala Leu Glu Gln Met Glu Tyr Gln Asn
        755                 760                 765             
Glu Gly Ile Asp Ala Val Pro Val Glu Tyr Glu Asp Asn Arg Pro Leu
    770                 775                 780                 
Leu Asp Met Phe Leu Gln Lys Pro Leu Gly Leu Leu Ala Leu Leu Asp
785                 790                 795                 800 
Glu Glu Ser Arg Phe Pro Gln Ala Thr Asp Gln Thr Leu Val Asp Lys
                805                 810                 815     
Phe Glu Asp Asn Leu Arg Cys Lys Tyr Phe Trp Arg Pro Lys Gly Val
            820                 825                 830         
Glu Leu Cys Phe Gly Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Asp
        835                 840                 845             
Ala Ser Gly Val Leu Glu Lys Asn Arg Asp Thr Leu Pro Ala Asp Val
    850                 855                 860                 
Val Val Val Leu Arg Thr Ser Glu Asn Lys Leu Leu Gln Gln Leu Phe
865                 870                 875                 880 
Ser Ile Pro Leu Thr Lys Thr Gly Asn Leu Ala Gln Thr Arg Ala Arg
                885                 890                 895     
Ile Thr Val Ala Ser Ser Ser Leu Pro Pro His Phe Ser Ala Gly Lys
            900                 905                 910         
Ala Lys Val Asp Thr Leu Glu Val Ile Arg His Pro Glu Glu Thr Thr
        915                 920                 925             
Asn Met Lys Arg Gln Thr Val Ala Ser Tyr Phe Arg Tyr Ser Leu Met
    930                 935                 940                 
Asp Leu Leu Ser Lys Met Val Val Gly Gln Pro His Phe Val Arg Cys
945                 950                 955                 960 
Ile Lys Pro Asn Asp Asp Arg Glu Ala Leu Gln Phe Ser Arg Glu Arg
                965                 970                 975     
Val Leu Ala Gln Leu Arg Ser Thr Gly Ile Leu Glu Thr Val Ser Ile
            980                 985                 990         
Arg Arg Gln Gly Tyr Ser His Arg Ile Leu Phe Glu Glu Phe Val Lys
        995                 1000                1005            
Arg Tyr Tyr Tyr Leu Ala Phe Thr Ala His Gln Thr Pro Leu Ala Ser
    1010                1015                1020                
Lys Glu Ser Cys Val Ala Ile Leu Glu Lys Ser Arg Leu Asp His Trp
1025                1030                1035                1040
Val Leu Gly Lys Thr Lys Val Phe Leu Lys Tyr Tyr His Val Glu Gln
                1045                1050                1055    
Leu Asn Leu Leu Leu Arg Glu Val Ile Gly Arg Val Val Val Leu Gln
            1060                1065                1070        
Ala Tyr Thr Lys Gly Trp Leu Gly Ala Arg Arg Tyr Lys Arg Val Arg
        1075                1080                1085            
Glu Lys Arg Glu Lys Gly Ala Ile Ala Ile Gln Ser Ala Trp Arg Gly
    1090                1095                1100                
Tyr Asp Ala Arg Arg Lys Phe Lys Lys Ile Ser Asn Arg Arg Asn Glu
1105                1110                1115                1120
Ser Ala Ala His Asn Gln Ala Gly Asp Thr Ser Asn Gln Ser Ser Gly
                1125                1130                1135    
Pro His Ser Pro Val Ala Ala Gly Thr Arg Gly Ser Ala Glu Val Gln
            1140                1145                1150        
Asp Cys Ser Glu Pro Gly Asp His Lys Val Leu Arg Gly Ser Val His
        1155                1160                1165            
Arg Arg Ser His Ser Gln Ala Glu Ser Asn Asn Gly Arg Thr Gln Thr
    1170                1175                1180                
Ser Ser Asn Ser Pro Ala Val Thr Glu Lys Asn Gly His Ser Gln Ala
1185                1190                1195                1200
Gln Ser Ser Pro Lys Gly Cys Asp Ile Phe Ala Gly His Ala Asn Lys
                1205                1210                1215    
His Ser Val Ser Gly Thr Asp Leu Leu Ser Ser Arg Ile Cys His Pro
            1220                1225                1230        
Ala Pro Asp Gln Gln Gly Leu Ser Leu Trp Gly Ala Pro Gln Lys Pro
        1235                1240                1245            
Gly Ser Glu Asn Gly Leu Ala Gln Lys His Arg Thr Pro Arg Arg Arg
    1250                1255                1260                
Cys Gln Gln Pro Lys Met Leu Ser Ser Pro Glu Asp Thr Met Tyr Tyr
1265                1270                1275                1280
Asn Gln Leu Asn Gly Thr Leu Glu Tyr Gln Gly Ser Lys Arg Lys Pro
                1285                1290                1295    
Arg Lys Leu Gly Gln Ile Lys Val Leu Asp Gly Glu Asp Glu Tyr Tyr
            1300                1305                1310        
Lys Ser Leu Ser Pro Val Asp Cys Ile Pro Glu Glu Asn Asn Ser Ala
        1315                1320                1325            
His Pro Ser Phe Phe Ser Ser Ser Ser Lys Gly Asp Ser Phe Ala Gln
    1330                1335                1340                
His
1345


<210> 9370
<211> 1985
<212> PRT
<213> Homo sapiens

<400> 9370
Pro Gly Cys Ala Ala Arg Leu Ser Arg Ala Arg Ala Pro Gly Pro Gly
 1               5                  10                  15      
Ala Ala Gly Ala Gly Arg Lys Arg Leu Ala Asp Pro Gly Pro Pro Pro
            20                  25                  30          
Ala Ser Arg Arg Leu Arg Ala Pro Gly Ser Arg Pro Arg Leu Ala Pro
        35                  40                  45              
Cys Thr Arg Arg Ala Ala Gln Pro Ala His Ala Arg Met Ala Pro Arg
    50                  55                  60                  
Ala Ala Gly Gly Ala Pro Leu Ser Ala Arg Ala Ala Ala Ala Ser Pro
65                  70                  75                  80  
Pro Pro Phe Gln Thr Pro Pro Arg Cys Pro Val Pro Leu Leu Leu Leu
                85                  90                  95      
Leu Leu Leu Gly Ala Ala Arg Ala Gly Ala Leu Glu Ile Gln Arg Arg
            100                 105                 110         
Phe Pro Ser Pro Thr Pro Thr Asn Asn Phe Ala Leu Asp Gly Ala Ala
        115                 120                 125             
Gly Thr Val Tyr Leu Ala Ala Val Asn Arg Leu Tyr Gln Leu Ser Gly
    130                 135                 140                 
Ala Asn Leu Ser Leu Glu Ala Glu Ala Ala Val Gly Pro Val Pro Asp
145                 150                 155                 160 
Ser Pro Leu Cys His Ala Pro Gln Leu Pro Gln Ala Ser Cys Glu His
                165                 170                 175     
Pro Arg Arg Leu Thr Asp Asn Tyr Asn Lys Ile Leu Gln Leu Asp Pro
            180                 185                 190         
Gly Gln Gly Leu Val Val Val Cys Gly Ser Ile Tyr Gln Gly Phe Cys
        195                 200                 205             
Gln Leu Arg Arg Arg Gly Asn Ile Ser Ala Val Ala Val Arg Phe Pro
    210                 215                 220                 
Pro Ala Ala Pro Pro Ala Glu Pro Val Thr Val Phe Pro Ser Met Leu
225                 230                 235                 240 
Asn Val Ala Ala Asn His Pro Asn Ala Ser Thr Val Gly Leu Val Leu
                245                 250                 255     
Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg Leu Leu Val Gly Ala Thr
            260                 265                 270         
Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro Arg Asn Arg Ser Leu Glu
        275                 280                 285             
Asp His Arg Phe Glu Asn Thr Pro Glu Ile Ala Ile Arg Ser Leu Asp
    290                 295                 300                 
Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr Phe Asp Leu Asn Pro Ser
305                 310                 315                 320 
Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly Ala Lys Glu Gln His Lys
                325                 330                 335     
Leu Gly Phe Val Ser Ala Phe Leu His Pro Ser Asp Pro Pro Pro Gly
            340                 345                 350         
Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn Ser Glu Ala Arg Ala Gly
        355                 360                 365             
Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu Ala Arg Ile Cys Leu Pro
    370                 375                 380                 
His Gly Ala Gly Gly Asp Ala Lys Lys Leu Thr Glu Ser Tyr Ile Gln
385                 390                 395                 400 
Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly Arg Gly Asp Leu Tyr Ser
                405                 410                 415     
Arg Leu Val Ser Val Phe Pro Ala Arg Glu Arg Leu Phe Ala Val Phe
            420                 425                 430         
Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg Ala Ala Pro Ala Ala Leu
        435                 440                 445             
Cys Ala Phe Arg Phe Ala Asp Val Arg Ala Ala Ile Arg Ala Ala Arg
    450                 455                 460                 
Thr Ala Cys Phe Val Glu Pro Ala Pro Asp Val Val Ala Val Leu Asp
465                 470                 475                 480 
Ser Val Val Gln Gly Thr Gly Pro Ala Cys Glu Arg Lys Leu Asn Ile
                485                 490                 495     
Gln Leu Gln Pro Glu Gln Leu Asp Cys Gly Ala Ala His Leu Gln His
            500                 505                 510         
Pro Leu Ser Ile Leu Gln Pro Leu Lys Ala Thr Pro Val Phe Arg Ala
        515                 520                 525             
Pro Gly Leu Thr Ser Val Ala Val Ala Ser Val Asn Asn Tyr Thr Ala
    530                 535                 540                 
Val Phe Leu Gly Thr Val Asn Gly Arg Leu Leu Lys Ile Asn Leu Asn
545                 550                 555                 560 
Glu Ser Met Gln Val Val Ser Arg Arg Val Val Thr Val Ala Tyr Gly
                565                 570                 575     
Glu Pro Val His His Val Met Gln Phe Asp Pro Ala Asp Ser Val Tyr
            580                 585                 590         
Leu Tyr Leu Met Thr Ser His Gln Met Ala Arg Val Lys Val Ala Ala
        595                 600                 605             
Cys Asn Val His Ser Thr Cys Gly Asp Cys Val Gly Ala Ala Asp Ala
    610                 615                 620                 
Tyr Cys Gly Trp Cys Ala Leu Glu Thr Arg Cys Thr Leu Gln Gln Asp
625                 630                 635                 640 
Cys Thr Asn Ser Ser Gln Gln His Phe Trp Thr Ser Ala Ser Glu Gly
                645                 650                 655     
Pro Ser Arg Cys Pro Ala Met Thr Val Leu Pro Ser Glu Ile Asp Val
            660                 665                 670         
Arg Gln Glu Tyr Pro Gly Met Ile Leu Gln Ile Ser Gly Ser Leu Pro
        675                 680                 685             
Ser Leu Ser Gly Met Glu Met Ala Cys Asp Tyr Gly Asn Asn Ile Arg
    690                 695                 700                 
Thr Val Ala Arg Val Pro Gly Pro Ala Phe Gly His Gln Ile Ala Tyr
705                 710                 715                 720 
Cys Asn Leu Leu Pro Arg Asp Gln Phe Pro Pro Phe Pro Pro Asn Gln
                725                 730                 735     
Asp His Val Thr Val Glu Met Ser Val Arg Val Asn Gly Arg Asn Ile
            740                 745                 750         
Val Lys Ala Asn Phe Thr Ile Tyr Asp Cys Ser Arg Thr Ala Gln Val
        755                 760                 765             
Tyr Pro His Thr Ala Cys Thr Ser Cys Leu Ser Ala Gln Trp Pro Cys
    770                 775                 780                 
Phe Trp Cys Ser Gln Gln His Ser Cys Val Ser Asn Gln Ser Arg Cys
785                 790                 795                 800 
Glu Ala Ser Pro Asn Pro Thr Ser Pro Gln Asp Cys Pro Arg Thr Leu
                805                 810                 815     
Leu Ser Pro Leu Ala Pro Val Pro Thr Gly Gly Ser Gln Asn Ile Leu
            820                 825                 830         
Val Pro Leu Ala Asn Thr Ala Phe Phe Gln Gly Ala Ala Leu Glu Cys
        835                 840                 845             
Ser Phe Gly Leu Glu Glu Ile Phe Glu Ala Val Trp Val Asn Glu Ser
    850                 855                 860                 
Val Val Arg Cys Asp Gln Val Val Leu His Thr Thr Arg Lys Ser Gln
865                 870                 875                 880 
Val Phe Pro Leu Ser Leu Gln Leu Lys Gly Arg Pro Ala Arg Phe Leu
                885                 890                 895     
Asp Ser Pro Glu Pro Met Thr Val Met Val Tyr Asn Cys Ala Met Gly
            900                 905                 910         
Ser Pro Asp Cys Ser Gln Cys Leu Gly Arg Glu Asp Leu Gly His Leu
        915                 920                 925             
Cys Met Trp Ser Asp Gly Cys Arg Leu Arg Gly Pro Leu Gln Pro Met
    930                 935                 940                 
Ala Gly Thr Cys Pro Ala Pro Glu Ile Arg Ala Ile Glu Pro Leu Ser
945                 950                 955                 960 
Gly Pro Leu Asp Gly Gly Thr Leu Leu Thr Ile Arg Gly Arg Asn Leu
                965                 970                 975     
Gly Arg Arg Leu Ser Asp Val Ala His Gly Val Trp Ile Gly Gly Val
            980                 985                 990         
Ala Cys Glu Pro Leu Pro Asp Arg Tyr Thr Val Ser Glu Glu Ile Val
        995                 1000                1005            
Cys Val Thr Gly Pro Ala Pro Gly Pro Leu Ser Gly Val Val Thr Val
    1010                1015                1020                
Asn Ala Ser Lys Glu Gly Lys Ser Arg Asp Arg Phe Ser Tyr Val Leu
1025                1030                1035                1040
Pro Leu Val His Ser Leu Glu Pro Thr Met Gly Pro Lys Ala Gly Gly
                1045                1050                1055    
Thr Arg Ile Thr Ile His Gly Asn Asp Leu His Val Gly Ser Glu Leu
            1060                1065                1070        
Gln Val Leu Val Asn Asp Thr Asp Pro Cys Thr Glu Leu Met Arg Thr
        1075                1080                1085            
Asp Thr Ser Ile Ala Cys Thr Met Pro Glu Gly Ala Leu Pro Ala Pro
    1090                1095                1100                
Val Pro Val Cys Val Arg Phe Glu Arg Arg Gly Cys Val His Gly Asn
1105                1110                1115                1120
Leu Thr Phe Trp Tyr Met Gln Asn Pro Val Ile Thr Ala Ile Ser Pro
                1125                1130                1135    
Arg Arg Ser Pro Val Ser Gly Gly Arg Thr Ile Thr Val Ala Gly Glu
            1140                1145                1150        
Arg Phe His Met Val Gln Asn Val Ser Met Ala Val His His Ile Gly
        1155                1160                1165            
Arg Glu Pro Thr Leu Cys Lys Val Leu Asn Ser Thr Leu Ile Thr Cys
    1170                1175                1180                
Pro Ser Pro Gly Ala Leu Ser Asn Ala Ser Ala Pro Val Asp Phe Phe
1185                1190                1195                1200
Ile Asn Gly Arg Ala Tyr Ala Asp Glu Val Ala Val Ala Glu Glu Leu
                1205                1210                1215    
Leu Asp Pro Glu Glu Ala Gln Arg Gly Ser Arg Phe Arg Leu Asp Tyr
            1220                1225                1230        
Leu Pro Asn Pro Gln Phe Ser Thr Ala Lys Arg Glu Lys Trp Ile Lys
        1235                1240                1245            
His His Pro Gly Glu Pro Leu Thr Leu Val Ile His Lys Glu Gln Asp
    1250                1255                1260                
Ser Leu Gly Leu Gln Ser His Glu Tyr Arg Val Lys Ile Gly Gln Val
1265                1270                1275                1280
Ser Cys Asp Ile Gln Ile Val Ser Asp Arg Ile Ile His Cys Ser Val
                1285                1290                1295    
Asn Glu Ser Leu Gly Ala Ala Val Gly Gln Leu Pro Ile Thr Ile Gln
            1300                1305                1310        
Val Gly Asn Phe Asn Gln Thr Ile Ala Thr Leu Gln Leu Gly Gly Ser
        1315                1320                1325            
Glu Thr Ala Ile Ile Val Ser Ile Val Ile Cys Ser Val Leu Leu Leu
    1330                1335                1340                
Leu Ser Val Val Ala Leu Phe Val Phe Cys Thr Lys Ser Arg Arg Ala
1345                1350                1355                1360
Glu Arg Tyr Trp Gln Lys Thr Leu Leu Gln Met Glu Glu Met Glu Ser
                1365                1370                1375    
Gln Ile Arg Glu Glu Ile Arg Lys Gly Phe Ala Glu Leu Gln Thr Asp
            1380                1385                1390        
Met Thr Asp Leu Thr Lys Glu Leu Asn Arg Ser Gln Gly Ile Pro Phe
        1395                1400                1405            
Leu Glu Tyr Lys His Phe Val Thr Arg Thr Phe Phe Pro Lys Cys Ser
    1410                1415                1420                
Ser Leu Tyr Glu Glu Arg Tyr Val Leu Pro Ser Gln Thr Leu Asn Ser
1425                1430                1435                1440
Gln Gly Ser Ser Gln Ala Gln Glu Thr His Pro Leu Leu Gly Glu Trp
                1445                1450                1455    
Lys Ile Pro Glu Ser Cys Arg Pro Asn Met Glu Glu Gly Ile Ser Leu
            1460                1465                1470        
Phe Ser Ser Leu Leu Asn Asn Lys His Phe Leu Ile Val Phe Val His
        1475                1480                1485            
Ala Leu Glu Gln Gln Lys Asp Phe Ala Val Arg Asp Arg Cys Ser Leu
    1490                1495                1500                
Ala Ser Leu Leu Thr Ile Ala Leu His Gly Lys Leu Glu Tyr Tyr Thr
1505                1510                1515                1520
Ser Ile Met Lys Glu Leu Leu Val Asp Leu Ile Asp Ala Ser Ala Ala
                1525                1530                1535    
Lys Asn Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys
            1540                1545                1550        
Met Leu Thr Asn Trp Met Ser Ile Cys Met Tyr Ser Cys Leu Arg Glu
        1555                1560                1565            
Thr Val Gly Glu Pro Phe Phe Leu Leu Leu Cys Ala Ile Lys Gln Gln
    1570                1575                1580                
Ile Asn Lys Gly Ser Ile Asp Ala Ile Thr Gly Lys Ala Arg Tyr Thr
1585                1590                1595                1600
Leu Asn Glu Glu Trp Leu Leu Arg Glu Asn Ile Glu Ala Lys Pro Arg
                1605                1610                1615    
Asn Leu Asn Val Ser Phe Gln Gly Cys Gly Met Asp Ser Leu Ser Val
            1620                1625                1630        
Arg Ala Met Asp Thr Asp Thr Leu Thr Gln Val Lys Glu Lys Ile Leu
        1635                1640                1645            
Glu Ala Phe Cys Lys Asn Val Pro Tyr Ser Gln Trp Pro Arg Ala Glu
    1650                1655                1660                
Asp Val Asp Leu Glu Trp Phe Ala Ser Ser Thr Gln Ser Tyr Ile Leu
1665                1670                1675                1680
Arg Asp Leu Asp Asp Thr Ser Val Val Glu Asp Gly Arg Lys Lys Leu
                1685                1690                1695    
Asn Thr Leu Ala His Tyr Lys Ile Pro Glu Gly Ala Ser Leu Ala Met
            1700                1705                1710        
Ser Leu Ile Asp Lys Lys Asp Asn Thr Leu Gly Arg Val Lys Asp Leu
        1715                1720                1725            
Asp Thr Glu Lys Tyr Phe His Leu Val Leu Pro Thr Asp Glu Leu Ala
    1730                1735                1740                
Glu Pro Lys Lys Ser His Arg Gln Ser His Arg Lys Lys Val Leu Pro
1745                1750                1755                1760
Glu Ile Tyr Leu Thr Arg Leu Leu Ser Thr Lys Gly Thr Leu Gln Lys
                1765                1770                1775    
Phe Leu Asp Asp Leu Phe Lys Ala Ile Leu Ser Ile Arg Glu Asp Lys
            1780                1785                1790        
Pro Pro Leu Ala Val Lys Tyr Phe Phe Asp Phe Leu Glu Glu Gln Ala
        1795                1800                1805            
Glu Lys Arg Gly Ile Ser Asp Pro Asp Thr Leu His Ile Trp Lys Thr
    1810                1815                1820                
Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro Gln
1825                1830                1835                1840
Phe Val Phe Asp Ile Asp Lys Thr Asp His Ile Asp Ala Cys Leu Ser
                1845                1850                1855    
Val Ile Ala Gln Ala Phe Ile Asp Ala Cys Ser Ile Ser Asp Leu Gln
            1860                1865                1870        
Leu Gly Lys Asp Ser Pro Thr Asn Lys Leu Leu Tyr Ala Lys Glu Ile
        1875                1880                1885            
Pro Glu Tyr Arg Lys Ile Val Gln Arg Tyr Tyr Lys Gln Ile Gln Asp
    1890                1895                1900                
Met Thr Pro Leu Ser Glu Gln Glu Met Asn Ala His Leu Ala Glu Glu
1905                1910                1915                1920
Ser Arg Lys Tyr Gln Asn Glu Phe Asn Thr Asn Val Ala Met Ala Glu
                1925                1930                1935    
Ile Tyr Lys Tyr Ala Lys Arg Tyr Arg Pro Gln Ile Met Ala Ala Leu
            1940                1945                1950        
Glu Ala Asn Pro Thr Ala Arg Arg Thr Gln Leu Gln His Lys Phe Glu
        1955                1960                1965            
Gln Val Val Ala Leu Met Glu Asp Asn Ile Tyr Glu Cys Tyr Ser Glu
    1970                1975                1980                
Ala
1985


<210> 9371
<211> 791
<212> PRT
<213> Homo sapiens

<400> 9371
Met Ser Gln Pro Arg Pro Arg Tyr Val Val Asp Arg Ala Ala Tyr Ser
 1               5                  10                  15      
Leu Thr Leu Phe Asp Asp Glu Phe Glu Lys Lys Asp Arg Thr Tyr Pro
            20                  25                  30          
Val Gly Glu Lys Leu Arg Asn Ala Phe Arg Cys Ser Ser Ala Lys Ile
        35                  40                  45              
Lys Ala Val Val Phe Gly Leu Leu Pro Val Leu Ser Trp Leu Pro Lys
    50                  55                  60                  
Tyr Lys Ile Lys Asp Tyr Ile Ile Pro Asp Leu Leu Gly Gly Leu Ser
65                  70                  75                  80  
Gly Gly Ser Ile Gln Val Pro Gln Gly Met Ala Phe Ala Leu Leu Ala
                85                  90                  95      
Asn Leu Pro Ala Val Asn Gly Leu Tyr Ser Ser Phe Phe Pro Leu Leu
            100                 105                 110         
Thr Tyr Phe Phe Leu Gly Gly Val His Gln Met Val Pro Gly Thr Phe
        115                 120                 125             
Ala Val Ile Ser Ile Leu Val Gly Asn Ile Cys Leu Gln Leu Ala Pro
    130                 135                 140                 
Glu Ser Lys Phe Gln Val Phe Asn Asn Ala Thr Asn Glu Ser Tyr Val
145                 150                 155                 160 
Asp Thr Ala Ala Met Glu Ala Glu Arg Leu His Val Ser Ala Thr Leu
                165                 170                 175     
Ala Cys Leu Thr Ala Ile Ile Gln Met Gly Leu Gly Phe Met Gln Phe
            180                 185                 190         
Gly Phe Val Ala Ile Tyr Leu Ser Glu Ser Phe Ile Arg Gly Phe Met
        195                 200                 205             
Thr Ala Ala Gly Leu Gln Ile Leu Ile Ser Val Leu Lys Tyr Ile Phe
    210                 215                 220                 
Gly Leu Thr Ile Pro Ser Tyr Thr Gly Pro Gly Ser Ile Val Phe Thr
225                 230                 235                 240 
Phe Ile Asp Ile Cys Lys Asn Leu Pro His Thr Asn Ile Ala Ser Leu
                245                 250                 255     
Ile Phe Ala Leu Ile Ser Gly Ala Phe Leu Val Leu Val Lys Glu Leu
            260                 265                 270         
Asn Ala Arg Tyr Met His Lys Ile Arg Phe Pro Ile Pro Thr Glu Met
        275                 280                 285             
Ile Val Val Val Val Ala Thr Ala Ile Ser Gly Gly Cys Lys Met Pro
    290                 295                 300                 
Lys Lys Tyr His Met Gln Ile Val Gly Glu Ile Gln Arg Gly Phe Pro
305                 310                 315                 320 
Thr Pro Val Ser Pro Val Val Ser Gln Trp Lys Asp Met Ile Gly Thr
                325                 330                 335     
Ala Phe Ser Leu Ala Ile Val Ser Tyr Val Ile Asn Leu Ala Met Gly
            340                 345                 350         
Arg Thr Leu Ala Asn Lys His Gly Tyr Asp Val Asp Ser Asn Gln Glu
        355                 360                 365             
Met Ile Ala Leu Gly Cys Ser Asn Phe Phe Gly Ser Phe Phe Lys Ile
    370                 375                 380                 
His Val Ile Cys Cys Ala Leu Ser Val Thr Leu Ala Val Asp Gly Ala
385                 390                 395                 400 
Gly Gly Lys Ser Gln Val Ala Ser Leu Cys Val Ser Leu Val Val Met
                405                 410                 415     
Ile Thr Met Leu Val Leu Gly Ile Tyr Leu Tyr Pro Leu Pro Lys Ser
            420                 425                 430         
Val Leu Gly Ala Leu Ile Ala Val Asn Leu Lys Asn Ser Leu Lys Gln
        435                 440                 445             
Leu Thr Asp Pro Tyr Tyr Leu Trp Arg Lys Ser Lys Leu Asp Cys Cys
    450                 455                 460                 
Ile Trp Val Val Ser Phe Leu Ser Ser Phe Phe Leu Ser Leu Pro Tyr
465                 470                 475                 480 
Gly Val Ala Val Gly Val Ala Phe Ser Val Leu Val Val Val Phe Gln
                485                 490                 495     
Thr Gln Phe Arg Asn Gly Tyr Ala Leu Ala Gln Val Met Asp Thr Asp
            500                 505                 510         
Ile Tyr Val Asn Pro Lys Thr Tyr Asn Arg Ala Gln Asp Ile Gln Gly
        515                 520                 525             
Ile Lys Ile Ile Thr Tyr Cys Ser Pro Leu Tyr Phe Ala Asn Ser Glu
    530                 535                 540                 
Ile Phe Arg Gln Lys Val Ile Ala Lys Thr Gly Met Asp Pro Gln Lys
545                 550                 555                 560 
Val Leu Leu Ala Lys Gln Lys Tyr Leu Lys Lys Gln Glu Lys Arg Arg
                565                 570                 575     
Met Arg Pro Thr Gln Gln Arg Arg Ser Leu Phe Met Lys Thr Lys Thr
            580                 585                 590         
Val Ser Leu Gln Glu Leu Gln Gln Asp Phe Glu Asn Ala Pro Pro Thr
        595                 600                 605             
Asp Pro Asn Asn Asn Gln Thr Pro Ala Asn Gly Thr Ser Val Ser Tyr
    610                 615                 620                 
Ile Thr Phe Ser Pro Asp Ser Ser Ser Pro Ala Gln Ser Glu Pro Pro
625                 630                 635                 640 
Ala Ser Ala Glu Ala Pro Gly Glu Pro Ser Asp Met Leu Ala Ser Val
                645                 650                 655     
Pro Pro Phe Val Thr Phe His Thr Leu Ile Leu Asp Met Ser Gly Val
            660                 665                 670         
Ser Phe Val Asp Leu Met Gly Ile Lys Ala Leu Ala Lys Leu Ser Ser
        675                 680                 685             
Thr Tyr Gly Lys Ile Gly Val Lys Val Phe Leu Val Asn Ile His Ala
    690                 695                 700                 
Gln Val Tyr Asn Asp Ile Ser His Gly Gly Val Phe Glu Asp Gly Ser
705                 710                 715                 720 
Leu Glu Cys Lys His Val Phe Pro Ser Ile His Asp Ala Val Leu Phe
                725                 730                 735     
Ala Gln Ala Asn Ala Arg Asp Val Thr Pro Gly His Asn Phe Gln Gly
            740                 745                 750         
Ala Pro Gly Asp Ala Glu Leu Ser Leu Tyr Asp Ser Glu Glu Asp Ile
        755                 760                 765             
Arg Ser Tyr Trp Asp Leu Glu Gln Glu Met Phe Gly Ser Met Phe His
    770                 775                 780                 
Ala Glu Thr Leu Thr Ala Leu
785                 790     


<210> 9372
<211> 926
<212> PRT
<213> Homo sapiens

<400> 9372
Phe Glu Gln Ser Pro Phe Thr His Leu Arg Asn Thr Phe Arg Leu Pro
 1               5                  10                  15      
Ala Pro Gln Thr His Leu Gln Pro Cys Pro Ala Gly Phe Ala His Pro
            20                  25                  30          
Leu Leu Val Asn Ala Pro Asp Met Ser Gln Pro Arg Pro Arg Tyr Val
        35                  40                  45              
Val Asp Arg Ala Ala Tyr Ser Leu Thr Leu Phe Asp Asp Glu Phe Glu
    50                  55                  60                  
Lys Lys Asp Arg Thr Tyr Pro Val Gly Glu Lys Leu Arg Asn Ala Phe
65                  70                  75                  80  
Arg Cys Ser Ser Ala Lys Ile Lys Ala Val Val Phe Gly Leu Leu Pro
                85                  90                  95      
Val Leu Ser Trp Leu Pro Lys Tyr Lys Ile Lys Asp Tyr Ile Ile Pro
            100                 105                 110         
Asp Leu Leu Gly Gly Leu Ser Gly Gly Ser Ile Gln Val Pro Gln Gly
        115                 120                 125             
Met Ala Phe Ala Leu Leu Ala Asn Leu Pro Ala Val Asn Gly Leu Tyr
    130                 135                 140                 
Ser Ser Phe Phe Pro Leu Leu Thr Tyr Phe Phe Leu Gly Gly Val His
145                 150                 155                 160 
Gln Met Val Pro Gly Thr Phe Ala Val Ile Ser Ile Leu Val Gly Asn
                165                 170                 175     
Ile Cys Leu Gln Leu Ala Pro Glu Ser Lys Phe Gln Val Phe Asn Asn
            180                 185                 190         
Ala Thr Asn Glu Ser Tyr Val Asp Thr Ala Ala Met Glu Ala Glu Arg
        195                 200                 205             
Leu His Val Ser Ala Thr Leu Ala Cys Leu Thr Ala Ile Ile Gln Met
    210                 215                 220                 
Gly Leu Gly Phe Met Gln Phe Gly Phe Val Ala Ile Tyr Leu Ser Glu
225                 230                 235                 240 
Ser Phe Ile Arg Gly Phe Met Thr Ala Ala Gly Leu Gln Ile Leu Ile
                245                 250                 255     
Ser Val Leu Lys Tyr Ile Phe Gly Leu Thr Ile Pro Ser Tyr Thr Gly
            260                 265                 270         
Pro Gly Ser Ile Val Phe Thr Phe Ile Asp Ile Cys Lys Asn Leu Pro
        275                 280                 285             
His Thr Asn Ile Ala Ser Leu Ile Phe Ala Leu Ile Ser Gly Ala Phe
    290                 295                 300                 
Leu Val Leu Val Lys Glu Leu Asn Ala Arg Tyr Met His Lys Ile Arg
305                 310                 315                 320 
Phe Pro Ile Pro Thr Glu Met Ile Val Val Val Val Ala Thr Ala Ile
                325                 330                 335     
Ser Gly Gly Cys Lys Met Pro Lys Lys Tyr His Met Gln Ile Val Gly
            340                 345                 350         
Glu Ile Gln Arg Gly Phe Pro Thr Pro Val Ser Pro Val Val Ser Gln
        355                 360                 365             
Trp Lys Asp Met Ile Gly Thr Ala Phe Ser Leu Ala Ile Val Ser Tyr
    370                 375                 380                 
Val Ile Asn Leu Ala Met Gly Arg Thr Leu Ala Asn Lys His Gly Tyr
385                 390                 395                 400 
Asp Val Asp Ser Asn Gln Glu Met Ile Ala Leu Gly Cys Ser Asn Phe
                405                 410                 415     
Phe Gly Ser Phe Phe Lys Ile His Val Ile Cys Cys Ala Leu Ser Val
            420                 425                 430         
Thr Leu Ala Val Asp Gly Ala Gly Gly Lys Ser Gln Val Ala Ser Leu
        435                 440                 445             
Cys Val Ser Leu Val Val Met Ile Thr Met Leu Val Leu Gly Ile Tyr
    450                 455                 460                 
Leu Tyr Pro Leu Pro Lys Ser Val Leu Gly Ala Leu Ile Ala Val Asn
465                 470                 475                 480 
Leu Lys Asn Ser Leu Lys Gln Leu Thr Asp Pro Tyr Tyr Leu Trp Arg
                485                 490                 495     
Lys Ser Lys Leu Asp Cys Cys Ile Trp Val Val Ser Phe Leu Ser Ser
            500                 505                 510         
Phe Phe Leu Ser Leu Pro Tyr Gly Val Ala Val Gly Val Ala Phe Ser
        515                 520                 525             
Val Leu Val Val Val Phe Gln Thr Gln Phe Arg Asn Gly Tyr Ala Leu
    530                 535                 540                 
Ala Gln Val Met Asp Thr Asp Ile Tyr Val Asn Pro Lys Thr Tyr Asn
545                 550                 555                 560 
Arg Ala Gln Asp Ile Gln Gly Ile Lys Ile Ile Thr Tyr Cys Ser Pro
                565                 570                 575     
Leu Tyr Phe Ala Asn Ser Glu Ile Phe Arg Gln Lys Val Ile Ala Lys
            580                 585                 590         
Thr Gly Met Asp Pro Gln Lys Val Leu Leu Ala Lys Gln Lys Tyr Leu
        595                 600                 605             
Lys Lys Gln Glu Lys Arg Arg Met Arg Pro Thr Gln Gln Arg Arg Ser
    610                 615                 620                 
Leu Phe Met Lys Thr Lys Thr Val Ser Leu Gln Glu Leu Gln Gln Asp
625                 630                 635                 640 
Phe Glu Asn Ala Pro Pro Thr Asp Pro Asn Asn Asn Gln Thr Pro Ala
                645                 650                 655     
Asn Gly Thr Ser Val Ser Tyr Ile Thr Phe Ser Pro Asp Ser Ser Ser
            660                 665                 670         
Pro Ala Gln Ser Glu Pro Pro Ala Ser Ala Glu Ala Pro Gly Glu Pro
        675                 680                 685             
Ser Asp Met Leu Ala Ser Val Pro Pro Phe Val Thr Phe His Thr Leu
    690                 695                 700                 
Ile Leu Asp Met Ser Gly Val Ser Phe Val Asp Leu Met Gly Ile Lys
705                 710                 715                 720 
Ala Leu Ala Lys Leu Ser Ser Thr Tyr Gly Lys Ile Gly Val Lys Val
                725                 730                 735     
Phe Leu Val Asn Ile His Ala Gln Val Tyr Asn Asp Ile Ser His Gly
            740                 745                 750         
Gly Val Phe Glu Asp Gly Ser Leu Glu Cys Lys His Val Phe Pro Ser
        755                 760                 765             
Ile His Asp Ala Val Leu Phe Ala Gln Ala Asn Ala Arg Asp Val Thr
    770                 775                 780                 
Pro Gly His Asn Phe Gln Gly Ala Pro Gly Asp Ala Glu Leu Ser Leu
785                 790                 795                 800 
Tyr Asp Ser Glu Glu Asp Ile Arg Ser Tyr Trp Asp Leu Glu Gln Glu
                805                 810                 815     
Met Phe Gly Ser Met Phe His Ala Glu Thr Leu Thr Ala Arg Glu Ser
            820                 825                 830         
Leu Ser Ala Ala Gly Gly Cys Tyr Pro Tyr Arg Ser Glu Ser Leu Val
        835                 840                 845             
Ser Pro Leu Phe Thr Arg Gln Ala Leu Ala Ala Met Asp Lys Pro Pro
    850                 855                 860                 
Ala His Ser Thr Pro Pro Thr Ser Ala Leu Ser Leu Ala Ala Glu Gly
865                 870                 875                 880 
His Leu Asp Phe Gln Leu Leu Arg Val Ser Gln Lys Gln Lys Asp Lys
                885                 890                 895     
Tyr Asn Cys Ala Gly Leu Leu Tyr Lys Leu Gln Lys Val Ser Gln Ser
            900                 905                 910         
Pro His Gly Ser Val Ser Asp Gly Val Arg Leu Ser Arg Thr
        915                 920                 925     


<210> 9373
<211> 5038
<212> PRT
<213> Homo sapiens

<400> 9373
Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp
 1               5                  10                  15      
Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu
            20                  25                  30          
Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu
        35                  40                  45              
Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys
    50                  55                  60                  
Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met
65                  70                  75                  80  
Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly
                85                  90                  95      
His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His
            100                 105                 110         
Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp
        115                 120                 125             
Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala
    130                 135                 140                 
Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu
145                 150                 155                 160 
Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu
                165                 170                 175     
Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala
            180                 185                 190         
Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys
        195                 200                 205             
Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly
    210                 215                 220                 
His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln
225                 230                 235                 240 
Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg
                245                 250                 255     
Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His
            260                 265                 270         
Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln
        275                 280                 285             
Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser
    290                 295                 300                 
Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu
305                 310                 315                 320 
Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro
                325                 330                 335     
Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser
            340                 345                 350         
Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu
        355                 360                 365             
Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp
    370                 375                 380                 
Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala
385                 390                 395                 400 
Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser
                405                 410                 415     
Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly
            420                 425                 430         
Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile
        435                 440                 445             
Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln
    450                 455                 460                 
Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu
465                 470                 475                 480 
Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr
                485                 490                 495     
Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu
            500                 505                 510         
Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu
        515                 520                 525             
Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp
    530                 535                 540                 
Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu
545                 550                 555                 560 
Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile
                565                 570                 575     
Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His
            580                 585                 590         
Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys
        595                 600                 605             
Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu
    610                 615                 620                 
Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val
625                 630                 635                 640 
Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr
                645                 650                 655     
Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro
            660                 665                 670         
Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr
        675                 680                 685             
Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn
    690                 695                 700                 
Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu
705                 710                 715                 720 
Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu
                725                 730                 735     
Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro
            740                 745                 750         
Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu
        755                 760                 765             
Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala
    770                 775                 780                 
Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys
785                 790                 795                 800 
Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro
                805                 810                 815     
Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly
            820                 825                 830         
Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr
        835                 840                 845             
Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro
    850                 855                 860                 
His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu
865                 870                 875                 880 
Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg
                885                 890                 895     
Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu
            900                 905                 910         
Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu
        915                 920                 925             
Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys
    930                 935                 940                 
Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met
945                 950                 955                 960 
Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu
                965                 970                 975     
Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His
            980                 985                 990         
Asn Val Trp Ala Arg Asp Arg Val Gly Gln Gly Trp Ser Tyr Ser Ala
        995                 1000                1005            
Val Gln Asp Ile Pro Ala Arg Arg Asn Pro Arg Leu Val Pro Tyr Arg
    1010                1015                1020                
Leu Leu Asp Glu Ala Thr Lys Arg Ser Asn Arg Asp Ser Leu Cys Gln
1025                1030                1035                1040
Ala Val Arg Thr Leu Leu Gly Tyr Gly Tyr Asn Ile Glu Pro Pro Asp
                1045                1050                1055    
Gln Glu Pro Ser Gln Val Glu Asn Gln Ser Arg Cys Asp Arg Val Arg
            1060                1065                1070        
Ile Phe Arg Ala Glu Lys Ser Tyr Thr Val Gln Ser Gly Arg Trp Tyr
        1075                1080                1085            
Phe Glu Phe Glu Ala Val Thr Thr Gly Glu Met Arg Val Gly Trp Ala
    1090                1095                1100                
Arg Pro Glu Leu Arg Pro Asp Val Glu Leu Gly Ala Asp Glu Leu Ala
1105                1110                1115                1120
Tyr Val Phe Asn Gly His Arg Gly Gln Arg Trp His Leu Gly Ser Glu
                1125                1130                1135    
Pro Phe Gly Arg Pro Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile
            1140                1145                1150        
Asp Leu Thr Glu Asn Thr Ile Ile Phe Thr Leu Asn Gly Glu Val Leu
        1155                1160                1165            
Met Ser Asp Ser Gly Ser Glu Thr Ala Phe Arg Glu Ile Glu Ile Gly
    1170                1175                1180                
Asp Gly Phe Leu Pro Val Cys Ser Leu Gly Pro Gly Gln Val Gly His
1185                1190                1195                1200
Leu Asn Leu Gly Gln Asp Val Ser Ser Leu Arg Phe Phe Ala Ile Cys
                1205                1210                1215    
Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Ile Asn Met Gln Arg Pro
            1220                1225                1230        
Val Thr Thr Trp Phe Ser Lys Gly Leu Pro Gln Phe Glu Pro Val Pro
        1235                1240                1245            
Leu Glu His Pro His Tyr Glu Val Ser Arg Val Asp Gly Thr Val Asp
    1250                1255                1260                
Thr Pro Pro Cys Leu Arg Leu Thr His Arg Thr Trp Gly Ser Gln Asn
1265                1270                1275                1280
Ser Leu Val Glu Met Leu Phe Leu Arg Leu Ser Leu Pro Val Gln Phe
                1285                1290                1295    
His Gln His Phe Arg Cys Thr Ala Gly Ala Thr Pro Leu Ala Pro Pro
            1300                1305                1310        
Gly Leu Gln Pro Pro Ala Glu Asp Glu Ala Arg Ala Ala Glu Pro Asp
        1315                1320                1325            
Pro Asp Tyr Glu Asn Leu Arg Arg Ser Ala Gly Gly Trp Ser Glu Ala
    1330                1335                1340                
Glu Asn Gly Lys Glu Gly Thr Ala Lys Glu Gly Ala Pro Gly Gly Thr
1345                1350                1355                1360
Pro Gln Ala Gly Gly Glu Ala Gln Pro Ala Arg Ala Glu Asn Glu Lys
                1365                1370                1375    
Asp Ala Thr Thr Glu Lys Asn Lys Lys Arg Gly Phe Leu Phe Lys Ala
            1380                1385                1390        
Lys Lys Val Ala Met Met Thr Gln Pro Pro Ala Thr Pro Thr Leu Pro
        1395                1400                1405            
Arg Leu Pro His Asp Val Val Pro Ala Asp Asn Arg Asp Asp Pro Glu
    1410                1415                1420                
Ile Ile Leu Asn Thr Thr Thr Tyr Tyr Tyr Ser Val Arg Val Phe Ala
1425                1430                1435                1440
Gly Gln Glu Pro Ser Cys Val Trp Ala Gly Trp Val Thr Pro Asp Tyr
                1445                1450                1455    
His Gln His Asp Met Ser Phe Asp Leu Ser Lys Val Arg Val Val Thr
            1460                1465                1470        
Val Thr Met Gly Asp Glu Gln Gly Asn Val His Ser Ser Leu Lys Cys
        1475                1480                1485            
Ser Asn Cys Tyr Met Val Trp Gly Gly Asp Phe Val Ser Pro Gly Gln
    1490                1495                1500                
Gln Gly Arg Ile Ser His Thr Asp Leu Val Ile Gly Cys Leu Val Asp
1505                1510                1515                1520
Leu Ala Thr Gly Leu Met Thr Phe Thr Ala Asn Gly Lys Glu Ser Asn
                1525                1530                1535    
Thr Phe Phe Gln Val Glu Pro Asn Thr Lys Leu Phe Pro Ala Val Phe
            1540                1545                1550        
Val Leu Pro Thr His Gln Asn Val Ile Gln Phe Glu Leu Gly Lys Gln
        1555                1560                1565            
Lys Asn Ile Met Pro Leu Ser Ala Ala Met Phe Gln Ser Glu Arg Lys
    1570                1575                1580                
Asn Pro Ala Pro Gln Cys Pro Pro Arg Leu Glu Met Gln Met Leu Met
1585                1590                1595                1600
Pro Val Ser Trp Ser Arg Met Pro Asn His Phe Leu Gln Val Glu Thr
                1605                1610                1615    
Arg Arg Ala Gly Glu Arg Leu Gly Trp Ala Val Gln Cys Gln Glu Pro
            1620                1625                1630        
Leu Thr Met Met Ala Leu His Ile Pro Glu Glu Asn Arg Cys Met Asp
        1635                1640                1645            
Ile Leu Glu Leu Ser Glu Arg Leu Asp Leu Gln Arg Phe His Ser His
    1650                1655                1660                
Thr Leu Arg Leu Tyr Arg Ala Val Cys Ala Leu Gly Asn Asn Arg Val
1665                1670                1675                1680
Ala His Ala Leu Cys Ser His Val Asp Gln Ala Gln Leu Leu His Ala
                1685                1690                1695    
Leu Glu Asp Ala His Leu Pro Gly Pro Leu Arg Ala Gly Tyr Tyr Asp
            1700                1705                1710        
Leu Leu Ile Ser Ile His Leu Glu Ser Ala Cys Arg Ser Arg Arg Ser
        1715                1720                1725            
Met Leu Ser Glu Tyr Ile Val Pro Leu Thr Pro Glu Thr Arg Ala Ile
    1730                1735                1740                
Thr Leu Phe Pro Pro Gly Arg Ser Thr Glu Asn Gly His Pro Arg His
1745                1750                1755                1760
Gly Leu Pro Gly Val Gly Val Thr Thr Ser Leu Arg Pro Pro His His
                1765                1770                1775    
Phe Ser Pro Pro Cys Phe Val Ala Ala Leu Pro Ala Ala Gly Ala Ala
            1780                1785                1790        
Glu Ala Pro Ala Arg Leu Ser Pro Ala Ile Pro Leu Glu Ala Leu Arg
        1795                1800                1805            
Asp Lys Ala Leu Arg Met Leu Gly Glu Ala Val Arg Asp Gly Gly Gln
    1810                1815                1820                
His Ala Arg Asp Pro Val Gly Ala Ser Val Glu Phe Gln Phe Val Pro
1825                1830                1835                1840
Val Leu Lys Leu Val Ser Thr Leu Leu Val Met Gly Ile Phe Gly Asp
                1845                1850                1855    
Glu Asp Val Lys Gln Ile Leu Lys Met Ile Glu Pro Glu Val Phe Thr
            1860                1865                1870        
Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp
        1875                1880                1885            
Glu Glu Glu Lys Glu Glu Asp Glu Glu Glu Thr Ala Gln Glu Lys Glu
    1890                1895                1900                
Asp Glu Glu Lys Glu Glu Glu Glu Ala Ala Glu Gly Glu Lys Glu Glu
1905                1910                1915                1920
Gly Leu Glu Glu Gly Leu Leu Gln Met Lys Leu Pro Glu Ser Val Lys
                1925                1930                1935    
Leu Gln Met Cys His Leu Leu Glu Tyr Phe Cys Asp Gln Glu Leu Gln
            1940                1945                1950        
His Arg Val Glu Ser Leu Ala Ala Phe Ala Glu Arg Tyr Val Asp Lys
        1955                1960                1965            
Leu Gln Ala Asn Gln Arg Ser Arg Tyr Gly Leu Leu Ile Lys Ala Phe
    1970                1975                1980                
Ser Met Thr Ala Ala Glu Thr Ala Arg Arg Thr Arg Glu Phe Arg Ser
1985                1990                1995                2000
Pro Pro Gln Glu Gln Ile Asn Met Leu Leu Gln Phe Lys Asp Gly Thr
                2005                2010                2015    
Asp Glu Glu Asp Cys Pro Leu Pro Glu Glu Ile Arg Gln Asp Leu Leu
            2020                2025                2030        
Asp Phe His Gln Asp Leu Leu Ala His Cys Gly Ile Gln Leu Asp Gly
        2035                2040                2045            
Glu Glu Glu Glu Pro Glu Glu Glu Thr Thr Leu Gly Ser Arg Leu Met
    2050                2055                2060                
Ser Leu Leu Glu Lys Val Arg Leu Val Lys Lys Lys Glu Glu Lys Pro
2065                2070                2075                2080
Glu Glu Glu Arg Ser Ala Glu Glu Ser Lys Pro Arg Ser Leu Gln Glu
                2085                2090                2095    
Leu Val Ser His Met Val Val Arg Trp Ala Gln Glu Asp Phe Val Gln
            2100                2105                2110        
Ser Pro Glu Leu Val Arg Ala Met Phe Ser Leu Leu His Arg Gln Tyr
        2115                2120                2125            
Asp Gly Leu Gly Glu Leu Leu Arg Ala Leu Pro Arg Ala Tyr Thr Ile
    2130                2135                2140                
Ser Pro Ser Ser Val Glu Asp Thr Met Ser Leu Leu Glu Cys Leu Gly
2145                2150                2155                2160
Gln Ile Arg Ser Leu Leu Ile Val Gln Met Gly Pro Gln Glu Glu Asn
                2165                2170                2175    
Leu Met Ile Gln Ser Ile Gly Asn Ile Met Asn Asn Lys Val Phe Tyr
            2180                2185                2190        
Gln His Pro Asn Leu Met Arg Ala Leu Gly Met His Glu Thr Val Met
        2195                2200                2205            
Glu Val Met Val Asn Val Leu Gly Gly Gly Glu Ser Lys Glu Ile Arg
    2210                2215                2220                
Phe Pro Lys Met Val Thr Ser Cys Cys Arg Phe Leu Cys Tyr Phe Cys
2225                2230                2235                2240
Arg Ile Ser Arg Gln Asn Gln Arg Ser Met Phe Asp His Leu Ser Tyr
                2245                2250                2255    
Leu Leu Glu Asn Ser Gly Ile Gly Leu Gly Met Gln Gly Ser Thr Pro
            2260                2265                2270        
Leu Asp Val Ala Ala Ala Ser Val Ile Asp Asn Asn Glu Leu Ala Leu
        2275                2280                2285            
Ala Leu Gln Glu Gln Asp Leu Glu Lys Val Val Ser Tyr Leu Ala Gly
    2290                2295                2300                
Cys Gly Leu Gln Ser Cys Pro Met Leu Val Ala Lys Gly Tyr Pro Asp
2305                2310                2315                2320
Ile Gly Trp Asn Pro Cys Gly Gly Glu Arg Tyr Leu Asp Phe Leu Arg
                2325                2330                2335    
Phe Ala Val Phe Val Asn Gly Glu Ser Val Glu Glu Asn Ala Asn Val
            2340                2345                2350        
Val Val Arg Leu Leu Ile Arg Lys Pro Glu Cys Phe Gly Pro Ala Leu
        2355                2360                2365            
Arg Gly Glu Gly Gly Ser Gly Leu Leu Ala Ala Ile Glu Glu Ala Ile
    2370                2375                2380                
Arg Ile Ser Glu Asp Pro Ala Arg Asp Gly Pro Gly Ile Arg Arg Asp
2385                2390                2395                2400
Arg Arg Arg Glu His Phe Gly Glu Glu Pro Pro Glu Glu Asn Arg Val
                2405                2410                2415    
His Leu Gly His Ala Ile Met Ser Phe Tyr Ala Ala Leu Ile Asp Leu
            2420                2425                2430        
Leu Gly Arg Cys Ala Pro Glu Met His Leu Ile Gln Ala Gly Lys Gly
        2435                2440                2445            
Glu Ala Leu Arg Ile Arg Ala Ile Leu Arg Ser Leu Val Pro Leu Glu
    2450                2455                2460                
Asp Leu Val Gly Ile Ile Ser Leu Pro Leu Gln Ile Pro Thr Leu Gly
2465                2470                2475                2480
Lys Asp Gly Ala Leu Val Gln Pro Lys Met Ser Ala Ser Phe Val Pro
                2485                2490                2495    
Asp His Lys Ala Ser Met Val Leu Phe Leu Asp Arg Val Tyr Gly Ile
            2500                2505                2510        
Glu Asn Gln Asp Phe Leu Leu His Val Leu Asp Val Gly Phe Leu Pro
        2515                2520                2525            
Asp Met Arg Ala Ala Ala Ser Leu Asp Thr Ala Thr Phe Ser Thr Thr
    2530                2535                2540                
Glu Met Ala Leu Ala Val Asn Arg Tyr Leu Cys Leu Ala Val Leu Pro
2545                2550                2555                2560
Leu Ile Thr Lys Cys Ala Pro Leu Phe Ala Gly Thr Glu His Arg Ala
                2565                2570                2575    
Ile Met Val Asp Ser Met Leu His Thr Val Tyr Arg Leu Ser Arg Gly
            2580                2585                2590        
Arg Ser Leu Thr Lys Ala Gln Arg Asp Val Ile Glu Asp Cys Leu Met
        2595                2600                2605            
Ser Leu Cys Arg Tyr Ile Arg Pro Ser Met Leu Gln His Leu Leu Arg
    2610                2615                2620                
Arg Leu Val Phe Asp Val Pro Ile Leu Asn Glu Phe Ala Lys Met Pro
2625                2630                2635                2640
Leu Lys Leu Leu Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr Cys
                2645                2650                2655    
Leu Pro Thr Gly Trp Ala Asn Phe Gly Val Thr Ser Glu Glu Glu Leu
            2660                2665                2670        
His Leu Thr Arg Lys Leu Phe Trp Gly Ile Phe Asp Ser Leu Ala His
        2675                2680                2685            
Lys Lys Tyr Asp Pro Glu Leu Tyr Arg Met Ala Met Pro Cys Leu Cys
    2690                2695                2700                
Ala Ile Ala Gly Ala Leu Pro Pro Asp Tyr Val Asp Ala Ser Tyr Ser
2705                2710                2715                2720
Ser Lys Ala Glu Lys Lys Ala Thr Val Asp Ala Glu Gly Asn Phe Asp
                2725                2730                2735    
Pro Arg Pro Val Glu Thr Leu Asn Val Ile Ile Pro Glu Lys Leu Asp
            2740                2745                2750        
Ser Phe Ile Asn Lys Phe Ala Glu Tyr Thr His Glu Lys Trp Ala Phe
        2755                2760                2765            
Asp Lys Ile Gln Asn Asn Trp Ser Tyr Gly Glu Asn Ile Asp Glu Glu
    2770                2775                2780                
Leu Lys Thr His Pro Met Leu Arg Pro Tyr Lys Thr Phe Ser Glu Lys
2785                2790                2795                2800
Asp Lys Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Ala Met
                2805                2810                2815    
Ile Ala Trp Glu Trp Thr Ile Glu Lys Ala Arg Glu Gly Glu Glu Glu
            2820                2825                2830        
Lys Thr Glu Lys Lys Lys Thr Arg Lys Ile Ser Gln Ser Ala Gln Thr
        2835                2840                2845            
Tyr Asp Pro Arg Glu Gly Tyr Asn Pro Gln Pro Pro Asp Leu Ser Ala
    2850                2855                2860                
Val Thr Leu Ser Arg Glu Leu Gln Ala Met Ala Glu Gln Leu Ala Glu
2865                2870                2875                2880
Asn Tyr His Asn Thr Trp Gly Arg Lys Lys Lys Gln Glu Leu Glu Ala
                2885                2890                2895    
Lys Gly Gly Gly Thr His Pro Leu Leu Val Pro Tyr Asp Thr Leu Thr
            2900                2905                2910        
Ala Lys Glu Lys Ala Arg Asp Arg Glu Lys Ala Gln Glu Leu Leu Lys
        2915                2920                2925            
Phe Leu Gln Met Asn Gly Tyr Ala Val Thr Arg Gly Leu Lys Asp Met
    2930                2935                2940                
Glu Leu Asp Ser Ser Ser Ile Glu Lys Arg Phe Ala Phe Gly Phe Leu
2945                2950                2955                2960
Gln Gln Leu Leu Arg Trp Met Asp Ile Ser Gln Glu Phe Ile Ala His
                2965                2970                2975    
Leu Glu Ala Val Val Ser Ser Gly Arg Val Glu Lys Ser Pro His Glu
            2980                2985                2990        
Gln Glu Ile Lys Phe Phe Ala Lys Ile Leu Leu Pro Leu Ile Asn Gln
        2995                3000                3005            
Tyr Phe Thr Asn His Cys Leu Tyr Phe Leu Ser Thr Pro Ala Lys Val
    3010                3015                3020                
Leu Gly Ser Gly Gly His Ala Ser Asn Lys Glu Lys Glu Met Ile Thr
3025                3030                3035                3040
Ser Leu Phe Cys Lys Leu Ala Ala Leu Val Arg His Arg Val Ser Leu
                3045                3050                3055    
Phe Gly Thr Asp Ala Pro Ala Val Val Asn Cys Leu His Ile Leu Ala
            3060                3065                3070        
Arg Ser Leu Asp Ala Arg Thr Val Met Lys Ser Gly Pro Glu Ile Val
        3075                3080                3085            
Lys Ala Gly Leu Arg Ser Phe Phe Glu Ser Ala Ser Glu Asp Ile Glu
    3090                3095                3100                
Lys Met Val Glu Asn Leu Arg Leu Gly Lys Val Ser Gln Ala Arg Thr
3105                3110                3115                3120
Gln Val Lys Gly Val Gly Gln Asn Leu Thr Tyr Thr Thr Val Ala Leu
                3125                3130                3135    
Leu Pro Val Leu Thr Thr Leu Phe Gln His Ile Ala Gln His Gln Phe
            3140                3145                3150        
Gly Asp Asp Val Ile Leu Asp Asp Val Gln Val Ser Cys Tyr Arg Thr
        3155                3160                3165            
Leu Cys Ser Ile Tyr Ser Leu Gly Thr Thr Lys Asn Thr Tyr Val Glu
    3170                3175                3180                
Lys Leu Arg Pro Ala Leu Gly Glu Cys Leu Ala Arg Leu Ala Ala Ala
3185                3190                3195                3200
Met Pro Val Ala Phe Leu Glu Pro Gln Leu Asn Glu Tyr Asn Ala Cys
                3205                3210                3215    
Ser Val Tyr Thr Thr Lys Ser Pro Arg Glu Arg Ala Ile Leu Gly Leu
            3220                3225                3230        
Pro Asn Ser Val Glu Glu Met Cys Pro Asp Ile Pro Val Leu Glu Arg
        3235                3240                3245            
Leu Met Ala Asp Ile Gly Gly Leu Ala Glu Ser Gly Ala Arg Tyr Thr
    3250                3255                3260                
Glu Met Pro His Val Ile Glu Ile Thr Leu Pro Met Leu Cys Ser Tyr
3265                3270                3275                3280
Leu Pro Arg Trp Trp Glu Arg Gly Pro Glu Ala Pro Pro Ser Ala Leu
                3285                3290                3295    
Pro Ala Gly Ala Pro Pro Pro Cys Thr Ala Val Thr Ser Asp His Leu
            3300                3305                3310        
Asn Ser Leu Leu Gly Asn Ile Leu Arg Ile Ile Val Asn Asn Leu Gly
        3315                3320                3325            
Ile Asp Glu Ala Ser Trp Met Lys Arg Leu Ala Val Phe Ala Gln Pro
    3330                3335                3340                
Ile Val Ser Arg Ala Arg Pro Glu Leu Leu Gln Ser His Phe Ile Pro
3345                3350                3355                3360
Thr Ile Gly Arg Leu Arg Lys Arg Ala Gly Lys Val Val Ser Glu Glu
                3365                3370                3375    
Glu Gln Leu Arg Leu Glu Ala Lys Ala Glu Ala Gln Glu Gly Glu Leu
            3380                3385                3390        
Leu Val Arg Asp Glu Phe Ser Val Leu Cys Arg Asp Leu Tyr Ala Leu
        3395                3400                3405            
Tyr Pro Leu Leu Ile Arg Tyr Val Asp Asn Asn Arg Ala Gln Trp Leu
    3410                3415                3420                
Thr Glu Pro Asn Pro Ser Ala Glu Glu Leu Phe Arg Met Val Gly Glu
3425                3430                3435                3440
Ile Phe Ile Tyr Trp Ser Lys Ser His Asn Phe Lys Arg Glu Glu Gln
                3445                3450                3455    
Asn Phe Val Val Gln Asn Glu Ile Asn Asn Met Ser Phe Leu Thr Ala
            3460                3465                3470        
Asp Asn Lys Ser Lys Met Ala Lys Ala Gly Asp Ile Gln Ser Gly Gly
        3475                3480                3485            
Ser Asp Gln Glu Arg Thr Lys Lys Lys Arg Arg Gly Asp Arg Tyr Ser
    3490                3495                3500                
Val Gln Thr Ser Leu Ile Val Ala Thr Leu Lys Lys Met Leu Pro Ile
3505                3510                3515                3520
Gly Leu Asn Met Cys Ala Pro Thr Asp Gln Asp Leu Ile Thr Leu Ala
                3525                3530                3535    
Lys Thr Arg Tyr Ala Leu Lys Asp Thr Asp Glu Glu Val Arg Glu Phe
            3540                3545                3550        
Leu His Asn Asn Leu His Leu Gln Gly Lys Val Glu Gly Ser Pro Ser
        3555                3560                3565            
Leu Arg Trp Gln Met Ala Leu Tyr Arg Gly Val Pro Gly Arg Glu Glu
    3570                3575                3580                
Asp Ala Asp Asp Pro Glu Lys Ile Val Arg Arg Val Gln Glu Val Ser
3585                3590                3595                3600
Ala Val Leu Tyr Tyr Leu Asp Gln Thr Glu His Pro Tyr Lys Ser Lys
                3605                3610                3615    
Lys Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Arg Arg Ala Val
            3620                3625                3630        
Val Ala Cys Phe Arg Met Thr Pro Leu Tyr Asn Leu Pro Thr His Arg
        3635                3640                3645            
Ala Cys Asn Met Phe Leu Glu Ser Tyr Lys Ala Ala Trp Ile Leu Thr
    3650                3655                3660                
Glu Asp His Ser Phe Glu Asp Arg Met Ile Asp Asp Leu Ser Lys Ala
3665                3670                3675                3680
Gly Glu Gln Glu Glu Glu Glu Glu Glu Val Glu Glu Lys Lys Pro Asp
                3685                3690                3695    
Pro Leu His Gln Leu Val Leu His Phe Ser Arg Thr Ala Leu Thr Glu
            3700                3705                3710        
Lys Ser Lys Leu Asp Glu Asp Tyr Leu Tyr Met Ala Tyr Ala Asp Ile
        3715                3720                3725            
Met Ala Lys Ser Cys His Leu Glu Glu Gly Gly Glu Asn Gly Glu Ala
    3730                3735                3740                
Glu Glu Glu Val Glu Val Ser Phe Glu Glu Lys Gln Met Glu Lys Gln
3745                3750                3755                3760
Arg Leu Leu Tyr Gln Gln Ala Arg Leu His Thr Arg Gly Ala Ala Glu
                3765                3770                3775    
Met Val Leu Gln Met Ile Ser Ala Cys Lys Gly Glu Thr Gly Ala Met
            3780                3785                3790        
Val Ser Ser Thr Leu Lys Leu Gly Ile Ser Ile Leu Asn Gly Gly Asn
        3795                3800                3805            
Ala Glu Val Gln Gln Lys Met Leu Asp Tyr Leu Lys Asp Lys Lys Glu
    3810                3815                3820                
Val Gly Phe Phe Gln Ser Ile Gln Ala Leu Met Gln Thr Cys Ser Val
3825                3830                3835                3840
Leu Asp Leu Asn Ala Phe Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly
                3845                3850                3855    
Met Val Asn Glu Asp Gly Thr Val Ile Asn Arg Gln Asn Gly Glu Lys
            3860                3865                3870        
Val Met Ala Asp Asp Glu Phe Thr Gln Asp Leu Phe Arg Phe Leu Gln
        3875                3880                3885            
Leu Leu Cys Glu Gly His Asn Asn Asp Phe Gln Asn Tyr Leu Arg Thr
    3890                3895                3900                
Gln Thr Gly Asn Thr Thr Thr Ile Asn Ile Ile Ile Cys Thr Val Asp
3905                3910                3915                3920
Tyr Leu Leu Arg Leu Gln Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr
                3925                3930                3935    
Ser Gly Lys Asp Val Ile Glu Glu Gln Gly Lys Arg Asn Phe Ser Lys
            3940                3945                3950        
Ala Met Ser Val Ala Lys Gln Val Phe Asn Ser Leu Thr Glu Tyr Ile
        3955                3960                3965            
Gln Gly Pro Cys Thr Gly Asn Gln Gln Ser Leu Ala His Ser Arg Leu
    3970                3975                3980                
Trp Asp Ala Val Val Gly Phe Leu His Val Phe Ala His Met Met Met
3985                3990                3995                4000
Lys Leu Ala Gln Asp Ser Ser Gln Ile Glu Leu Leu Lys Glu Leu Leu
                4005                4010                4015    
Asp Leu Gln Lys Asp Met Val Val Met Leu Leu Ser Leu Leu Glu Gly
            4020                4025                4030        
Asn Val Val Asn Gly Met Ile Ala Arg Gln Met Val Asp Met Leu Val
        4035                4040                4045            
Glu Ser Ser Ser Asn Val Glu Met Ile Leu Lys Phe Phe Asp Met Phe
    4050                4055                4060                
Leu Lys Leu Lys Asp Ile Val Gly Ser Glu Ala Phe Gln Asp Tyr Val
4065                4070                4075                4080
Thr Asp Pro Arg Gly Leu Ile Ser Lys Lys Asp Phe Gln Lys Ala Met
                4085                4090                4095    
Asp Ser Gln Lys Gln Phe Ser Gly Pro Glu Ile Gln Phe Leu Leu Ser
            4100                4105                4110        
Cys Ser Glu Ala Asp Glu Asn Glu Met Ile Asn Cys Glu Glu Phe Ala
        4115                4120                4125            
Asn Arg Phe Gln Glu Pro Ala Arg Asp Ile Gly Phe Asn Val Ala Val
    4130                4135                4140                
Leu Leu Thr Asn Leu Ser Glu His Val Pro His Asp Pro Arg Leu His
4145                4150                4155                4160
Asn Phe Leu Glu Leu Ala Glu Ser Ile Leu Glu Tyr Phe Arg Pro Tyr
                4165                4170                4175    
Leu Gly Arg Ile Glu Ile Met Gly Ala Ser Arg Arg Ile Glu Arg Ile
            4180                4185                4190        
Tyr Phe Glu Ile Ser Glu Thr Asn Arg Ala Gln Trp Glu Met Pro Gln
        4195                4200                4205            
Val Lys Glu Ser Lys Arg Gln Phe Ile Phe Asp Val Val Asn Glu Gly
    4210                4215                4220                
Gly Glu Ala Glu Lys Met Glu Leu Phe Val Ser Phe Cys Glu Asp Thr
4225                4230                4235                4240
Ile Phe Glu Met Gln Ile Ala Ala Gln Ile Ser Glu Pro Glu Gly Glu
                4245                4250                4255    
Pro Glu Thr Asp Glu Asp Glu Gly Ala Gly Ala Ala Glu Ala Gly Ala
            4260                4265                4270        
Glu Gly Ala Glu Glu Gly Ala Ala Gly Leu Glu Gly Thr Ala Ala Thr
        4275                4280                4285            
Ala Ala Ala Gly Ala Thr Ala Arg Val Val Ala Ala Ala Gly Arg Ala
    4290                4295                4300                
Leu Arg Gly Leu Ser Tyr Arg Ser Leu Arg Arg Arg Val Arg Arg Leu
4305                4310                4315                4320
Arg Arg Leu Thr Ala Arg Glu Ala Ala Thr Ala Val Ala Ala Leu Leu
                4325                4330                4335    
Trp Ala Ala Val Thr Arg Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala
            4340                4345                4350        
Gly Ala Leu Gly Leu Leu Trp Gly Ser Leu Phe Gly Gly Gly Leu Val
        4355                4360                4365            
Glu Gly Ala Lys Lys Val Thr Val Thr Glu Leu Leu Ala Gly Met Pro
    4370                4375                4380                
Asp Pro Thr Ser Asp Glu Val His Gly Glu Gln Pro Ala Gly Pro Gly
4385                4390                4395                4400
Gly Asp Ala Asp Gly Glu Gly Ala Ser Glu Gly Ala Gly Asp Ala Ala
                4405                4410                4415    
Glu Gly Ala Gly Asp Glu Glu Glu Ala Val His Glu Ala Gly Pro Gly
            4420                4425                4430        
Gly Ala Asp Gly Ala Val Ala Val Thr Asp Gly Gly Pro Phe Arg Pro
        4435                4440                4445            
Glu Gly Ala Gly Gly Leu Gly Asp Met Gly Asp Thr Thr Pro Ala Glu
    4450                4455                4460                
Pro Pro Thr Pro Glu Gly Ser Pro Ile Leu Lys Arg Lys Leu Gly Val
4465                4470                4475                4480
Asp Gly Val Glu Glu Glu Leu Pro Pro Glu Pro Glu Pro Glu Pro Glu
                4485                4490                4495    
Pro Glu Leu Glu Pro Glu Lys Ala Asp Ala Glu Asn Gly Glu Lys Glu
            4500                4505                4510        
Glu Val Pro Glu Pro Thr Pro Glu Pro Pro Lys Lys Gln Ala Pro Pro
        4515                4520                4525            
Ser Pro Pro Pro Lys Lys Glu Glu Ala Gly Gly Glu Phe Trp Gly Glu
    4530                4535                4540                
Leu Glu Val Gln Arg Val Lys Phe Leu Asn Tyr Leu Ser Arg Asn Phe
4545                4550                4555                4560
Tyr Thr Leu Arg Phe Leu Ala Leu Phe Leu Ala Phe Ala Ile Asn Phe
                4565                4570                4575    
Ile Leu Leu Phe Tyr Lys Val Ser Asp Ser Pro Pro Gly Glu Asp Asp
            4580                4585                4590        
Met Glu Gly Ser Ala Ala Gly Asp Val Ser Gly Ala Gly Ser Gly Gly
        4595                4600                4605            
Ser Ser Gly Trp Gly Leu Gly Ala Gly Glu Glu Ala Glu Gly Asp Glu
    4610                4615                4620                
Asp Glu Asn Met Val Tyr Tyr Phe Leu Glu Glu Ser Thr Gly Tyr Met
4625                4630                4635                4640
Glu Pro Ala Leu Arg Cys Leu Ser Leu Leu His Thr Leu Val Ala Phe
                4645                4650                4655    
Leu Cys Ile Ile Gly Tyr Asn Cys Leu Lys Val Pro Leu Val Ile Phe
            4660                4665                4670        
Lys Arg Glu Lys Glu Leu Ala Arg Lys Leu Glu Phe Asp Gly Leu Tyr
        4675                4680                4685            
Ile Thr Glu Gln Pro Glu Asp Asp Asp Val Lys Gly Gln Trp Asp Arg
    4690                4695                4700                
Leu Val Leu Asn Thr Pro Ser Phe Pro Ser Asn Tyr Trp Asp Lys Phe
4705                4710                4715                4720
Val Lys Arg Lys Val Leu Asp Lys His Gly Asp Ile Tyr Gly Arg Glu
                4725                4730                4735    
Arg Ile Ala Glu Leu Leu Gly Met Asp Leu Ala Thr Leu Glu Ile Thr
            4740                4745                4750        
Ala His Asn Glu Arg Lys Pro Asn Pro Pro Pro Gly Leu Leu Thr Trp
        4755                4760                4765            
Leu Met Ser Ile Asp Val Lys Tyr Gln Ile Trp Lys Phe Gly Val Ile
    4770                4775                4780                
Phe Thr Asp Asn Ser Phe Leu Tyr Leu Gly Trp Tyr Met Val Met Ser
4785                4790                4795                4800
Leu Leu Gly His Tyr Asn Asn Phe Phe Phe Ala Ala His Leu Leu Asp
                4805                4810                4815    
Ile Ala Met Gly Val Lys Thr Leu Arg Thr Ile Leu Ser Ser Val Thr
            4820                4825                4830        
His Asn Gly Lys Gln Leu Val Met Thr Val Gly Leu Leu Ala Val Val
        4835                4840                4845            
Val Tyr Leu Tyr Thr Val Val Ala Phe Asn Phe Phe Arg Lys Phe Tyr
    4850                4855                4860                
Asn Lys Ser Glu Asp Glu Asp Glu Pro Asp Met Lys Cys Asp Asp Met
4865                4870                4875                4880
Met Thr Cys Tyr Leu Phe His Met Tyr Val Gly Val Arg Ala Gly Gly
                4885                4890                4895    
Gly Ile Gly Asp Glu Ile Glu Asp Pro Ala Gly Asp Glu Tyr Glu Leu
            4900                4905                4910        
Tyr Arg Val Val Phe Asp Ile Thr Phe Phe Phe Phe Val Ile Val Ile
        4915                4920                4925            
Leu Leu Ala Ile Ile Gln Gly Leu Ile Ile Asp Ala Phe Gly Glu Leu
    4930                4935                4940                
Arg Asp Gln Gln Glu Gln Val Lys Glu Asp Met Glu Thr Lys Cys Phe
4945                4950                4955                4960
Ile Cys Gly Ile Gly Ser Asp Tyr Phe Asp Thr Thr Pro His Gly Phe
                4965                4970                4975    
Glu Thr His Thr Leu Glu Glu His Asn Leu Ala Asn Tyr Met Phe Phe
            4980                4985                4990        
Leu Met Tyr Leu Ile Asn Lys Asp Glu Thr Glu His Thr Gly Gln Glu
        4995                5000                5005            
Ser Tyr Val Trp Lys Met Tyr Gln Glu Arg Cys Trp Asp Phe Phe Pro
    5010                5015                5020                
Ala Gly Asp Cys Phe Arg Lys Gln Tyr Glu Asp Gln Leu Ser
5025                5030                5035            


<210> 9374
<211> 5033
<212> PRT
<213> Homo sapiens

<400> 9374
Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp
 1               5                  10                  15      
Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu
            20                  25                  30          
Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu
        35                  40                  45              
Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys
    50                  55                  60                  
Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met
65                  70                  75                  80  
Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly
                85                  90                  95      
His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His
            100                 105                 110         
Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp
        115                 120                 125             
Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala
    130                 135                 140                 
Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu
145                 150                 155                 160 
Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu
                165                 170                 175     
Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala
            180                 185                 190         
Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys
        195                 200                 205             
Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly
    210                 215                 220                 
His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln
225                 230                 235                 240 
Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg
                245                 250                 255     
Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His
            260                 265                 270         
Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln
        275                 280                 285             
Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser
    290                 295                 300                 
Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu
305                 310                 315                 320 
Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro
                325                 330                 335     
Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser
            340                 345                 350         
Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu
        355                 360                 365             
Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp
    370                 375                 380                 
Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala
385                 390                 395                 400 
Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser
                405                 410                 415     
Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly
            420                 425                 430         
Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile
        435                 440                 445             
Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln
    450                 455                 460                 
Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu
465                 470                 475                 480 
Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr
                485                 490                 495     
Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu
            500                 505                 510         
Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu
        515                 520                 525             
Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp
    530                 535                 540                 
Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu
545                 550                 555                 560 
Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile
                565                 570                 575     
Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His
            580                 585                 590         
Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys
        595                 600                 605             
Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu
    610                 615                 620                 
Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val
625                 630                 635                 640 
Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr
                645                 650                 655     
Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro
            660                 665                 670         
Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr
        675                 680                 685             
Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn
    690                 695                 700                 
Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu
705                 710                 715                 720 
Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu
                725                 730                 735     
Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro
            740                 745                 750         
Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu
        755                 760                 765             
Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala
    770                 775                 780                 
Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys
785                 790                 795                 800 
Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro
                805                 810                 815     
Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly
            820                 825                 830         
Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr
        835                 840                 845             
Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro
    850                 855                 860                 
His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu
865                 870                 875                 880 
Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg
                885                 890                 895     
Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu
            900                 905                 910         
Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu
        915                 920                 925             
Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys
    930                 935                 940                 
Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met
945                 950                 955                 960 
Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu
                965                 970                 975     
Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His
            980                 985                 990         
Asn Val Trp Ala Arg Asp Arg Val Gly Gln Gly Trp Ser Tyr Ser Ala
        995                 1000                1005            
Val Gln Asp Ile Pro Ala Arg Arg Asn Pro Arg Leu Val Pro Tyr Arg
    1010                1015                1020                
Leu Leu Asp Glu Ala Thr Lys Arg Ser Asn Arg Asp Ser Leu Cys Gln
1025                1030                1035                1040
Ala Val Arg Thr Leu Leu Gly Tyr Gly Tyr Asn Ile Glu Pro Pro Asp
                1045                1050                1055    
Gln Glu Pro Ser Gln Val Glu Asn Gln Ser Arg Cys Asp Arg Val Arg
            1060                1065                1070        
Ile Phe Arg Ala Glu Lys Ser Tyr Thr Val Gln Ser Gly Arg Trp Tyr
        1075                1080                1085            
Phe Glu Phe Glu Ala Val Thr Thr Gly Glu Met Arg Val Gly Trp Ala
    1090                1095                1100                
Arg Pro Glu Leu Arg Pro Asp Val Glu Leu Gly Ala Asp Glu Leu Ala
1105                1110                1115                1120
Tyr Val Phe Asn Gly His Arg Gly Gln Arg Trp His Leu Gly Ser Glu
                1125                1130                1135    
Pro Phe Gly Arg Pro Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile
            1140                1145                1150        
Asp Leu Thr Glu Asn Thr Ile Ile Phe Thr Leu Asn Gly Glu Val Leu
        1155                1160                1165            
Met Ser Asp Ser Gly Ser Glu Thr Ala Phe Arg Glu Ile Glu Ile Gly
    1170                1175                1180                
Asp Gly Phe Leu Pro Val Cys Ser Leu Gly Pro Gly Gln Val Gly His
1185                1190                1195                1200
Leu Asn Leu Gly Gln Asp Val Ser Ser Leu Arg Phe Phe Ala Ile Cys
                1205                1210                1215    
Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Ile Asn Met Gln Arg Pro
            1220                1225                1230        
Val Thr Thr Trp Phe Ser Lys Gly Leu Pro Gln Phe Glu Pro Val Pro
        1235                1240                1245            
Leu Glu His Pro His Tyr Glu Val Ser Arg Val Asp Gly Thr Val Asp
    1250                1255                1260                
Thr Pro Pro Cys Leu Arg Leu Thr His Arg Thr Trp Gly Ser Gln Asn
1265                1270                1275                1280
Ser Leu Val Glu Met Leu Phe Leu Arg Leu Ser Leu Pro Val Gln Phe
                1285                1290                1295    
His Gln His Phe Arg Cys Thr Ala Gly Ala Thr Pro Leu Ala Pro Pro
            1300                1305                1310        
Gly Leu Gln Pro Pro Ala Glu Asp Glu Ala Arg Ala Ala Glu Pro Asp
        1315                1320                1325            
Pro Asp Tyr Glu Asn Leu Arg Arg Ser Ala Gly Gly Trp Ser Glu Ala
    1330                1335                1340                
Glu Asn Gly Lys Glu Gly Thr Ala Lys Glu Gly Ala Pro Gly Gly Thr
1345                1350                1355                1360
Pro Gln Ala Gly Gly Glu Ala Gln Pro Ala Arg Ala Glu Asn Glu Lys
                1365                1370                1375    
Asp Ala Thr Thr Glu Lys Asn Lys Lys Arg Gly Phe Leu Phe Lys Ala
            1380                1385                1390        
Lys Lys Val Ala Met Met Thr Gln Pro Pro Ala Thr Pro Thr Leu Pro
        1395                1400                1405            
Arg Leu Pro His Asp Val Val Pro Ala Asp Asn Arg Asp Asp Pro Glu
    1410                1415                1420                
Ile Ile Leu Asn Thr Thr Thr Tyr Tyr Tyr Ser Val Arg Val Phe Ala
1425                1430                1435                1440
Gly Gln Glu Pro Ser Cys Val Trp Ala Gly Trp Val Thr Pro Asp Tyr
                1445                1450                1455    
His Gln His Asp Met Ser Phe Asp Leu Ser Lys Val Arg Val Val Thr
            1460                1465                1470        
Val Thr Met Gly Asp Glu Gln Gly Asn Val His Ser Ser Leu Lys Cys
        1475                1480                1485            
Ser Asn Cys Tyr Met Val Trp Gly Gly Asp Phe Val Ser Pro Gly Gln
    1490                1495                1500                
Gln Gly Arg Ile Ser His Thr Asp Leu Val Ile Gly Cys Leu Val Asp
1505                1510                1515                1520
Leu Ala Thr Gly Leu Met Thr Phe Thr Ala Asn Gly Lys Glu Ser Asn
                1525                1530                1535    
Thr Phe Phe Gln Val Glu Pro Asn Thr Lys Leu Phe Pro Ala Val Phe
            1540                1545                1550        
Val Leu Pro Thr His Gln Asn Val Ile Gln Phe Glu Leu Gly Lys Gln
        1555                1560                1565            
Lys Asn Ile Met Pro Leu Ser Ala Ala Met Phe Gln Ser Glu Arg Lys
    1570                1575                1580                
Asn Pro Ala Pro Gln Cys Pro Pro Arg Leu Glu Met Gln Met Leu Met
1585                1590                1595                1600
Pro Val Ser Trp Ser Arg Met Pro Asn His Phe Leu Gln Val Glu Thr
                1605                1610                1615    
Arg Arg Ala Gly Glu Arg Leu Gly Trp Ala Val Gln Cys Gln Glu Pro
            1620                1625                1630        
Leu Thr Met Met Ala Leu His Ile Pro Glu Glu Asn Arg Cys Met Asp
        1635                1640                1645            
Ile Leu Glu Leu Ser Glu Arg Leu Asp Leu Gln Arg Phe His Ser His
    1650                1655                1660                
Thr Leu Arg Leu Tyr Arg Ala Val Cys Ala Leu Gly Asn Asn Arg Val
1665                1670                1675                1680
Ala His Ala Leu Cys Ser His Val Asp Gln Ala Gln Leu Leu His Ala
                1685                1690                1695    
Leu Glu Asp Ala His Leu Pro Gly Pro Leu Arg Ala Gly Tyr Tyr Asp
            1700                1705                1710        
Leu Leu Ile Ser Ile His Leu Glu Ser Ala Cys Arg Ser Arg Arg Ser
        1715                1720                1725            
Met Leu Ser Glu Tyr Ile Val Pro Leu Thr Pro Glu Thr Arg Ala Ile
    1730                1735                1740                
Thr Leu Phe Pro Pro Gly Arg Ser Thr Glu Asn Gly His Pro Arg His
1745                1750                1755                1760
Gly Leu Pro Gly Val Gly Val Thr Thr Ser Leu Arg Pro Pro His His
                1765                1770                1775    
Phe Ser Pro Pro Cys Phe Val Ala Ala Leu Pro Ala Ala Gly Ala Ala
            1780                1785                1790        
Glu Ala Pro Ala Arg Leu Ser Pro Ala Ile Pro Leu Glu Ala Leu Arg
        1795                1800                1805            
Asp Lys Ala Leu Arg Met Leu Gly Glu Ala Val Arg Asp Gly Gly Gln
    1810                1815                1820                
His Ala Arg Asp Pro Val Gly Ala Ser Val Glu Phe Gln Phe Val Pro
1825                1830                1835                1840
Val Leu Lys Leu Val Ser Thr Leu Leu Val Met Gly Ile Phe Gly Asp
                1845                1850                1855    
Glu Asp Val Lys Gln Ile Leu Lys Met Ile Glu Pro Glu Val Phe Thr
            1860                1865                1870        
Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp
        1875                1880                1885            
Glu Glu Glu Lys Glu Glu Asp Glu Glu Glu Thr Ala Gln Glu Lys Glu
    1890                1895                1900                
Asp Glu Glu Lys Glu Glu Glu Glu Ala Ala Glu Gly Glu Lys Glu Glu
1905                1910                1915                1920
Gly Leu Glu Glu Gly Leu Leu Gln Met Lys Leu Pro Glu Ser Val Lys
                1925                1930                1935    
Leu Gln Met Cys His Leu Leu Glu Tyr Phe Cys Asp Gln Glu Leu Gln
            1940                1945                1950        
His Arg Val Glu Ser Leu Ala Ala Phe Ala Glu Arg Tyr Val Asp Lys
        1955                1960                1965            
Leu Gln Ala Asn Gln Arg Ser Arg Tyr Gly Leu Leu Ile Lys Ala Phe
    1970                1975                1980                
Ser Met Thr Ala Ala Glu Thr Ala Arg Arg Thr Arg Glu Phe Arg Ser
1985                1990                1995                2000
Pro Pro Gln Glu Gln Ile Asn Met Leu Leu Gln Phe Lys Asp Gly Thr
                2005                2010                2015    
Asp Glu Glu Asp Cys Pro Leu Pro Glu Glu Ile Arg Gln Asp Leu Leu
            2020                2025                2030        
Asp Phe His Gln Asp Leu Leu Ala His Cys Gly Ile Gln Leu Asp Gly
        2035                2040                2045            
Glu Glu Glu Glu Pro Glu Glu Glu Thr Thr Leu Gly Ser Arg Leu Met
    2050                2055                2060                
Ser Leu Leu Glu Lys Val Arg Leu Val Lys Lys Lys Glu Glu Lys Pro
2065                2070                2075                2080
Glu Glu Glu Arg Ser Ala Glu Glu Ser Lys Pro Arg Ser Leu Gln Glu
                2085                2090                2095    
Leu Val Ser His Met Val Val Arg Trp Ala Gln Glu Asp Phe Val Gln
            2100                2105                2110        
Ser Pro Glu Leu Val Arg Ala Met Phe Ser Leu Leu His Arg Gln Tyr
        2115                2120                2125            
Asp Gly Leu Gly Glu Leu Leu Arg Ala Leu Pro Arg Ala Tyr Thr Ile
    2130                2135                2140                
Ser Pro Ser Ser Val Glu Asp Thr Met Ser Leu Leu Glu Cys Leu Gly
2145                2150                2155                2160
Gln Ile Arg Ser Leu Leu Ile Val Gln Met Gly Pro Gln Glu Glu Asn
                2165                2170                2175    
Leu Met Ile Gln Ser Ile Gly Asn Ile Met Asn Asn Lys Val Phe Tyr
            2180                2185                2190        
Gln His Pro Asn Leu Met Arg Ala Leu Gly Met His Glu Thr Val Met
        2195                2200                2205            
Glu Val Met Val Asn Val Leu Gly Gly Gly Glu Ser Lys Glu Ile Arg
    2210                2215                2220                
Phe Pro Lys Met Val Thr Ser Cys Cys Arg Phe Leu Cys Tyr Phe Cys
2225                2230                2235                2240
Arg Ile Ser Arg Gln Asn Gln Arg Ser Met Phe Asp His Leu Ser Tyr
                2245                2250                2255    
Leu Leu Glu Asn Ser Gly Ile Gly Leu Gly Met Gln Gly Ser Thr Pro
            2260                2265                2270        
Leu Asp Val Ala Ala Ala Ser Val Ile Asp Asn Asn Glu Leu Ala Leu
        2275                2280                2285            
Ala Leu Gln Glu Gln Asp Leu Glu Lys Val Val Ser Tyr Leu Ala Gly
    2290                2295                2300                
Cys Gly Leu Gln Ser Cys Pro Met Leu Val Ala Lys Gly Tyr Pro Asp
2305                2310                2315                2320
Ile Gly Trp Asn Pro Cys Gly Gly Glu Arg Tyr Leu Asp Phe Leu Arg
                2325                2330                2335    
Phe Ala Val Phe Val Asn Gly Glu Ser Val Glu Glu Asn Ala Asn Val
            2340                2345                2350        
Val Val Arg Leu Leu Ile Arg Lys Pro Glu Cys Phe Gly Pro Ala Leu
        2355                2360                2365            
Arg Gly Glu Gly Gly Ser Gly Leu Leu Ala Ala Ile Glu Glu Ala Ile
    2370                2375                2380                
Arg Ile Ser Glu Asp Pro Ala Arg Asp Gly Pro Gly Ile Arg Arg Asp
2385                2390                2395                2400
Arg Arg Arg Glu His Phe Gly Glu Glu Pro Pro Glu Glu Asn Arg Val
                2405                2410                2415    
His Leu Gly His Ala Ile Met Ser Phe Tyr Ala Ala Leu Ile Asp Leu
            2420                2425                2430        
Leu Gly Arg Cys Ala Pro Glu Met His Leu Ile Gln Ala Gly Lys Gly
        2435                2440                2445            
Glu Ala Leu Arg Ile Arg Ala Ile Leu Arg Ser Leu Val Pro Leu Glu
    2450                2455                2460                
Asp Leu Val Gly Ile Ile Ser Leu Pro Leu Gln Ile Pro Thr Leu Gly
2465                2470                2475                2480
Lys Asp Gly Ala Leu Val Gln Pro Lys Met Ser Ala Ser Phe Val Pro
                2485                2490                2495    
Asp His Lys Ala Ser Met Val Leu Phe Leu Asp Arg Val Tyr Gly Ile
            2500                2505                2510        
Glu Asn Gln Asp Phe Leu Leu His Val Leu Asp Val Gly Phe Leu Pro
        2515                2520                2525            
Asp Met Arg Ala Ala Ala Ser Leu Asp Thr Ala Thr Phe Ser Thr Thr
    2530                2535                2540                
Glu Met Ala Leu Ala Val Asn Arg Tyr Leu Cys Leu Ala Val Leu Pro
2545                2550                2555                2560
Leu Ile Thr Lys Cys Ala Pro Leu Phe Ala Gly Thr Glu His Arg Ala
                2565                2570                2575    
Ile Met Val Asp Ser Met Leu His Thr Val Tyr Arg Leu Ser Arg Gly
            2580                2585                2590        
Arg Ser Leu Thr Lys Ala Gln Arg Asp Val Ile Glu Asp Cys Leu Met
        2595                2600                2605            
Ser Leu Cys Arg Tyr Ile Arg Pro Ser Met Leu Gln His Leu Leu Arg
    2610                2615                2620                
Arg Leu Val Phe Asp Val Pro Ile Leu Asn Glu Phe Ala Lys Met Pro
2625                2630                2635                2640
Leu Lys Leu Leu Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr Cys
                2645                2650                2655    
Leu Pro Thr Gly Trp Ala Asn Phe Gly Val Thr Ser Glu Glu Glu Leu
            2660                2665                2670        
His Leu Thr Arg Lys Leu Phe Trp Gly Ile Phe Asp Ser Leu Ala His
        2675                2680                2685            
Lys Lys Tyr Asp Pro Glu Leu Tyr Arg Met Ala Met Pro Cys Leu Cys
    2690                2695                2700                
Ala Ile Ala Gly Ala Leu Pro Pro Asp Tyr Val Asp Ala Ser Tyr Ser
2705                2710                2715                2720
Ser Lys Ala Glu Lys Lys Ala Thr Val Asp Ala Glu Gly Asn Phe Asp
                2725                2730                2735    
Pro Arg Pro Val Glu Thr Leu Asn Val Ile Ile Pro Glu Lys Leu Asp
            2740                2745                2750        
Ser Phe Ile Asn Lys Phe Ala Glu Tyr Thr His Glu Lys Trp Ala Phe
        2755                2760                2765            
Asp Lys Ile Gln Asn Asn Trp Ser Tyr Gly Glu Asn Ile Asp Glu Glu
    2770                2775                2780                
Leu Lys Thr His Pro Met Leu Arg Pro Tyr Lys Thr Phe Ser Glu Lys
2785                2790                2795                2800
Asp Lys Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Ala Met
                2805                2810                2815    
Ile Ala Trp Glu Trp Thr Ile Glu Lys Ala Arg Glu Gly Glu Glu Glu
            2820                2825                2830        
Lys Thr Glu Lys Lys Lys Thr Arg Lys Ile Ser Gln Ser Ala Gln Thr
        2835                2840                2845            
Tyr Asp Pro Arg Glu Gly Tyr Asn Pro Gln Pro Pro Asp Leu Ser Ala
    2850                2855                2860                
Val Thr Leu Ser Arg Glu Leu Gln Ala Met Ala Glu Gln Leu Ala Glu
2865                2870                2875                2880
Asn Tyr His Asn Thr Trp Gly Arg Lys Lys Lys Gln Glu Leu Glu Ala
                2885                2890                2895    
Lys Gly Gly Gly Thr His Pro Leu Leu Val Pro Tyr Asp Thr Leu Thr
            2900                2905                2910        
Ala Lys Glu Lys Ala Arg Asp Arg Glu Lys Ala Gln Glu Leu Leu Lys
        2915                2920                2925            
Phe Leu Gln Met Asn Gly Tyr Ala Val Thr Arg Gly Leu Lys Asp Met
    2930                2935                2940                
Glu Leu Asp Ser Ser Ser Ile Glu Lys Arg Phe Ala Phe Gly Phe Leu
2945                2950                2955                2960
Gln Gln Leu Leu Arg Trp Met Asp Ile Ser Gln Glu Phe Ile Ala His
                2965                2970                2975    
Leu Glu Ala Val Val Ser Ser Gly Arg Val Glu Lys Ser Pro His Glu
            2980                2985                2990        
Gln Glu Ile Lys Phe Phe Ala Lys Ile Leu Leu Pro Leu Ile Asn Gln
        2995                3000                3005            
Tyr Phe Thr Asn His Cys Leu Tyr Phe Leu Ser Thr Pro Ala Lys Val
    3010                3015                3020                
Leu Gly Ser Gly Gly His Ala Ser Asn Lys Glu Lys Glu Met Ile Thr
3025                3030                3035                3040
Ser Leu Phe Cys Lys Leu Ala Ala Leu Val Arg His Arg Val Ser Leu
                3045                3050                3055    
Phe Gly Thr Asp Ala Pro Ala Val Val Asn Cys Leu His Ile Leu Ala
            3060                3065                3070        
Arg Ser Leu Asp Ala Arg Thr Val Met Lys Ser Gly Pro Glu Ile Val
        3075                3080                3085            
Lys Ala Gly Leu Arg Ser Phe Phe Glu Ser Ala Ser Glu Asp Ile Glu
    3090                3095                3100                
Lys Met Val Glu Asn Leu Arg Leu Gly Lys Val Ser Gln Ala Arg Thr
3105                3110                3115                3120
Gln Val Lys Gly Val Gly Gln Asn Leu Thr Tyr Thr Thr Val Ala Leu
                3125                3130                3135    
Leu Pro Val Leu Thr Thr Leu Phe Gln His Ile Ala Gln His Gln Phe
            3140                3145                3150        
Gly Asp Asp Val Ile Leu Asp Asp Val Gln Val Ser Cys Tyr Arg Thr
        3155                3160                3165            
Leu Cys Ser Ile Tyr Ser Leu Gly Thr Thr Lys Asn Thr Tyr Val Glu
    3170                3175                3180                
Lys Leu Arg Pro Ala Leu Gly Glu Cys Leu Ala Arg Leu Ala Ala Ala
3185                3190                3195                3200
Met Pro Val Ala Phe Leu Glu Pro Gln Leu Asn Glu Tyr Asn Ala Cys
                3205                3210                3215    
Ser Val Tyr Thr Thr Lys Ser Pro Arg Glu Arg Ala Ile Leu Gly Leu
            3220                3225                3230        
Pro Asn Ser Val Glu Glu Met Cys Pro Asp Ile Pro Val Leu Glu Arg
        3235                3240                3245            
Leu Met Ala Asp Ile Gly Gly Leu Ala Glu Ser Gly Ala Arg Tyr Thr
    3250                3255                3260                
Glu Met Pro His Val Ile Glu Ile Thr Leu Pro Met Leu Cys Ser Tyr
3265                3270                3275                3280
Leu Pro Arg Trp Trp Glu Arg Gly Pro Glu Ala Pro Pro Ser Ala Leu
                3285                3290                3295    
Pro Ala Gly Ala Pro Pro Pro Cys Thr Ala Val Thr Ser Asp His Leu
            3300                3305                3310        
Asn Ser Leu Leu Gly Asn Ile Leu Arg Ile Ile Val Asn Asn Leu Gly
        3315                3320                3325            
Ile Asp Glu Ala Ser Trp Met Lys Arg Leu Ala Val Phe Ala Gln Pro
    3330                3335                3340                
Ile Val Ser Arg Ala Arg Pro Glu Leu Leu Gln Ser His Phe Ile Pro
3345                3350                3355                3360
Thr Ile Gly Arg Leu Arg Lys Arg Ala Gly Lys Val Val Ser Glu Glu
                3365                3370                3375    
Glu Gln Leu Arg Leu Glu Ala Lys Ala Glu Ala Gln Glu Gly Glu Leu
            3380                3385                3390        
Leu Val Arg Asp Glu Phe Ser Val Leu Cys Arg Asp Leu Tyr Ala Leu
        3395                3400                3405            
Tyr Pro Leu Leu Ile Arg Tyr Val Asp Asn Asn Arg Ala Gln Trp Leu
    3410                3415                3420                
Thr Glu Pro Asn Pro Ser Ala Glu Glu Leu Phe Arg Met Val Gly Glu
3425                3430                3435                3440
Ile Phe Ile Tyr Trp Ser Lys Ser His Asn Phe Lys Arg Glu Glu Gln
                3445                3450                3455    
Asn Phe Val Val Gln Asn Glu Ile Asn Asn Met Ser Phe Leu Thr Ala
            3460                3465                3470        
Asp Asn Lys Ser Lys Met Ala Lys Ala Gly Asp Ile Gln Ser Gly Gly
        3475                3480                3485            
Ser Asp Gln Glu Arg Thr Lys Lys Lys Arg Arg Gly Asp Arg Tyr Ser
    3490                3495                3500                
Val Gln Thr Ser Leu Ile Val Ala Thr Leu Lys Lys Met Leu Pro Ile
3505                3510                3515                3520
Gly Leu Asn Met Cys Ala Pro Thr Asp Gln Asp Leu Ile Thr Leu Ala
                3525                3530                3535    
Lys Thr Arg Tyr Ala Leu Lys Asp Thr Asp Glu Glu Val Arg Glu Phe
            3540                3545                3550        
Leu His Asn Asn Leu His Leu Gln Gly Lys Val Glu Gly Ser Pro Ser
        3555                3560                3565            
Leu Arg Trp Gln Met Ala Leu Tyr Arg Gly Val Pro Gly Arg Glu Glu
    3570                3575                3580                
Asp Ala Asp Asp Pro Glu Lys Ile Val Arg Arg Val Gln Glu Val Ser
3585                3590                3595                3600
Ala Val Leu Tyr Tyr Leu Asp Gln Thr Glu His Pro Tyr Lys Ser Lys
                3605                3610                3615    
Lys Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Arg Arg Ala Val
            3620                3625                3630        
Val Ala Cys Phe Arg Met Thr Pro Leu Tyr Asn Leu Pro Thr His Arg
        3635                3640                3645            
Ala Cys Asn Met Phe Leu Glu Ser Tyr Lys Ala Ala Trp Ile Leu Thr
    3650                3655                3660                
Glu Asp His Ser Phe Glu Asp Arg Met Ile Asp Asp Leu Ser Lys Ala
3665                3670                3675                3680
Gly Glu Gln Glu Glu Glu Glu Glu Glu Val Glu Glu Lys Lys Pro Asp
                3685                3690                3695    
Pro Leu His Gln Leu Val Leu His Phe Ser Arg Thr Ala Leu Thr Glu
            3700                3705                3710        
Lys Ser Lys Leu Asp Glu Asp Tyr Leu Tyr Met Ala Tyr Ala Asp Ile
        3715                3720                3725            
Met Ala Lys Ser Cys His Leu Glu Glu Gly Gly Glu Asn Gly Glu Ala
    3730                3735                3740                
Glu Glu Glu Val Glu Val Ser Phe Glu Glu Lys Gln Met Glu Lys Gln
3745                3750                3755                3760
Arg Leu Leu Tyr Gln Gln Ala Arg Leu His Thr Arg Gly Ala Ala Glu
                3765                3770                3775    
Met Val Leu Gln Met Ile Ser Ala Cys Lys Gly Glu Thr Gly Ala Met
            3780                3785                3790        
Val Ser Ser Thr Leu Lys Leu Gly Ile Ser Ile Leu Asn Gly Gly Asn
        3795                3800                3805            
Ala Glu Val Gln Gln Lys Met Leu Asp Tyr Leu Lys Asp Lys Lys Glu
    3810                3815                3820                
Val Gly Phe Phe Gln Ser Ile Gln Ala Leu Met Gln Thr Cys Ser Val
3825                3830                3835                3840
Leu Asp Leu Asn Ala Phe Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly
                3845                3850                3855    
Met Val Asn Glu Asp Gly Thr Val Gly Glu Lys Val Met Ala Asp Asp
            3860                3865                3870        
Glu Phe Thr Gln Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu Gly
        3875                3880                3885            
His Asn Asn Asp Phe Gln Asn Tyr Leu Arg Thr Gln Thr Gly Asn Thr
    3890                3895                3900                
Thr Thr Ile Asn Ile Ile Ile Cys Thr Val Asp Tyr Leu Leu Arg Leu
3905                3910                3915                3920
Gln Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp Val
                3925                3930                3935    
Ile Glu Glu Gln Gly Lys Arg Asn Phe Ser Lys Ala Met Ser Val Ala
            3940                3945                3950        
Lys Gln Val Phe Asn Ser Leu Thr Glu Tyr Ile Gln Gly Pro Cys Thr
        3955                3960                3965            
Gly Asn Gln Gln Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val Val
    3970                3975                3980                
Gly Phe Leu His Val Phe Ala His Met Met Met Lys Leu Ala Gln Asp
3985                3990                3995                4000
Ser Ser Gln Ile Glu Leu Leu Lys Glu Leu Leu Asp Leu Gln Lys Asp
                4005                4010                4015    
Met Val Val Met Leu Leu Ser Leu Leu Glu Gly Asn Val Val Asn Gly
            4020                4025                4030        
Met Ile Ala Arg Gln Met Val Asp Met Leu Val Glu Ser Ser Ser Asn
        4035                4040                4045            
Val Glu Met Ile Leu Lys Phe Phe Asp Met Phe Leu Lys Leu Lys Asp
    4050                4055                4060                
Ile Val Gly Ser Glu Ala Phe Gln Asp Tyr Val Thr Asp Pro Arg Gly
4065                4070                4075                4080
Leu Ile Ser Lys Lys Asp Phe Gln Lys Ala Met Asp Ser Gln Lys Gln
                4085                4090                4095    
Phe Ser Gly Pro Glu Ile Gln Phe Leu Leu Ser Cys Ser Glu Ala Asp
            4100                4105                4110        
Glu Asn Glu Met Ile Asn Cys Glu Glu Phe Ala Asn Arg Phe Gln Glu
        4115                4120                4125            
Pro Ala Arg Asp Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn Leu
    4130                4135                4140                
Ser Glu His Val Pro His Asp Pro Arg Leu His Asn Phe Leu Glu Leu
4145                4150                4155                4160
Ala Glu Ser Ile Leu Glu Tyr Phe Arg Pro Tyr Leu Gly Arg Ile Glu
                4165                4170                4175    
Ile Met Gly Ala Ser Arg Arg Ile Glu Arg Ile Tyr Phe Glu Ile Ser
            4180                4185                4190        
Glu Thr Asn Arg Ala Gln Trp Glu Met Pro Gln Val Lys Glu Ser Lys
        4195                4200                4205            
Arg Gln Phe Ile Phe Asp Val Val Asn Glu Gly Gly Glu Ala Glu Lys
    4210                4215                4220                
Met Glu Leu Phe Val Ser Phe Cys Glu Asp Thr Ile Phe Glu Met Gln
4225                4230                4235                4240
Ile Ala Ala Gln Ile Ser Glu Pro Glu Gly Glu Pro Glu Thr Asp Glu
                4245                4250                4255    
Asp Glu Gly Ala Gly Ala Ala Glu Ala Gly Ala Glu Gly Ala Glu Glu
            4260                4265                4270        
Gly Ala Ala Gly Leu Glu Gly Thr Ala Ala Thr Ala Ala Ala Gly Ala
        4275                4280                4285            
Thr Ala Arg Val Val Ala Ala Ala Gly Arg Ala Leu Arg Gly Leu Ser
    4290                4295                4300                
Tyr Arg Ser Leu Arg Arg Arg Val Arg Arg Leu Arg Arg Leu Thr Ala
4305                4310                4315                4320
Arg Glu Ala Ala Thr Ala Val Ala Ala Leu Leu Trp Ala Ala Val Thr
                4325                4330                4335    
Arg Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly Ala Leu Gly Leu
            4340                4345                4350        
Leu Trp Gly Ser Leu Phe Gly Gly Gly Leu Val Glu Gly Ala Lys Lys
        4355                4360                4365            
Val Thr Val Thr Glu Leu Leu Ala Gly Met Pro Asp Pro Thr Ser Asp
    4370                4375                4380                
Glu Val His Gly Glu Gln Pro Ala Gly Pro Gly Gly Asp Ala Asp Gly
4385                4390                4395                4400
Glu Gly Ala Ser Glu Gly Ala Gly Asp Ala Ala Glu Gly Ala Gly Asp
                4405                4410                4415    
Glu Glu Glu Ala Val His Glu Ala Gly Pro Gly Gly Ala Asp Gly Ala
            4420                4425                4430        
Val Ala Val Thr Asp Gly Gly Pro Phe Arg Pro Glu Gly Ala Gly Gly
        4435                4440                4445            
Leu Gly Asp Met Gly Asp Thr Thr Pro Ala Glu Pro Pro Thr Pro Glu
    4450                4455                4460                
Gly Ser Pro Ile Leu Lys Arg Lys Leu Gly Val Asp Gly Val Glu Glu
4465                4470                4475                4480
Glu Leu Pro Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu Pro
                4485                4490                4495    
Glu Lys Ala Asp Ala Glu Asn Gly Glu Lys Glu Glu Val Pro Glu Pro
            4500                4505                4510        
Thr Pro Glu Pro Pro Lys Lys Gln Ala Pro Pro Ser Pro Pro Pro Lys
        4515                4520                4525            
Lys Glu Glu Ala Gly Gly Glu Phe Trp Gly Glu Leu Glu Val Gln Arg
    4530                4535                4540                
Val Lys Phe Leu Asn Tyr Leu Ser Arg Asn Phe Tyr Thr Leu Arg Phe
4545                4550                4555                4560
Leu Ala Leu Phe Leu Ala Phe Ala Ile Asn Phe Ile Leu Leu Phe Tyr
                4565                4570                4575    
Lys Val Ser Asp Ser Pro Pro Gly Glu Asp Asp Met Glu Gly Ser Ala
            4580                4585                4590        
Ala Gly Asp Val Ser Gly Ala Gly Ser Gly Gly Ser Ser Gly Trp Gly
        4595                4600                4605            
Leu Gly Ala Gly Glu Glu Ala Glu Gly Asp Glu Asp Glu Asn Met Val
    4610                4615                4620                
Tyr Tyr Phe Leu Glu Glu Ser Thr Gly Tyr Met Glu Pro Ala Leu Arg
4625                4630                4635                4640
Cys Leu Ser Leu Leu His Thr Leu Val Ala Phe Leu Cys Ile Ile Gly
                4645                4650                4655    
Tyr Asn Cys Leu Lys Val Pro Leu Val Ile Phe Lys Arg Glu Lys Glu
            4660                4665                4670        
Leu Ala Arg Lys Leu Glu Phe Asp Gly Leu Tyr Ile Thr Glu Gln Pro
        4675                4680                4685            
Glu Asp Asp Asp Val Lys Gly Gln Trp Asp Arg Leu Val Leu Asn Thr
    4690                4695                4700                
Pro Ser Phe Pro Ser Asn Tyr Trp Asp Lys Phe Val Lys Arg Lys Val
4705                4710                4715                4720
Leu Asp Lys His Gly Asp Ile Tyr Gly Arg Glu Arg Ile Ala Glu Leu
                4725                4730                4735    
Leu Gly Met Asp Leu Ala Thr Leu Glu Ile Thr Ala His Asn Glu Arg
            4740                4745                4750        
Lys Pro Asn Pro Pro Pro Gly Leu Leu Thr Trp Leu Met Ser Ile Asp
        4755                4760                4765            
Val Lys Tyr Gln Ile Trp Lys Phe Gly Val Ile Phe Thr Asp Asn Ser
    4770                4775                4780                
Phe Leu Tyr Leu Gly Trp Tyr Met Val Met Ser Leu Leu Gly His Tyr
4785                4790                4795                4800
Asn Asn Phe Phe Phe Ala Ala His Leu Leu Asp Ile Ala Met Gly Val
                4805                4810                4815    
Lys Thr Leu Arg Thr Ile Leu Ser Ser Val Thr His Asn Gly Lys Gln
            4820                4825                4830        
Leu Val Met Thr Val Gly Leu Leu Ala Val Val Val Tyr Leu Tyr Thr
        4835                4840                4845            
Val Val Ala Phe Asn Phe Phe Arg Lys Phe Tyr Asn Lys Ser Glu Asp
    4850                4855                4860                
Glu Asp Glu Pro Asp Met Lys Cys Asp Asp Met Met Thr Cys Tyr Leu
4865                4870                4875                4880
Phe His Met Tyr Val Gly Val Arg Ala Gly Gly Gly Ile Gly Asp Glu
                4885                4890                4895    
Ile Glu Asp Pro Ala Gly Asp Glu Tyr Glu Leu Tyr Arg Val Val Phe
            4900                4905                4910        
Asp Ile Thr Phe Phe Phe Phe Val Ile Val Ile Leu Leu Ala Ile Ile
        4915                4920                4925            
Gln Gly Leu Ile Ile Asp Ala Phe Gly Glu Leu Arg Asp Gln Gln Glu
    4930                4935                4940                
Gln Val Lys Glu Asp Met Glu Thr Lys Cys Phe Ile Cys Gly Ile Gly
4945                4950                4955                4960
Ser Asp Tyr Phe Asp Thr Thr Pro His Gly Phe Glu Thr His Thr Leu
                4965                4970                4975    
Glu Glu His Asn Leu Ala Asn Tyr Met Phe Phe Leu Met Tyr Leu Ile
            4980                4985                4990        
Asn Lys Asp Glu Thr Glu His Thr Gly Gln Glu Ser Tyr Val Trp Lys
        4995                5000                5005            
Met Tyr Gln Glu Arg Cys Trp Asp Phe Phe Pro Ala Gly Asp Cys Phe
    5010                5015                5020                
Arg Lys Gln Tyr Glu Asp Gln Leu Ser
5025                5030            


<210> 9375
<211> 5033
<212> PRT
<213> Homo sapiens

<400> 9375
Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp
 1               5                  10                  15      
Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu
            20                  25                  30          
Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu
        35                  40                  45              
Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys
    50                  55                  60                  
Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met
65                  70                  75                  80  
Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly
                85                  90                  95      
His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His
            100                 105                 110         
Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp
        115                 120                 125             
Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala
    130                 135                 140                 
Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu
145                 150                 155                 160 
Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu
                165                 170                 175     
Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala
            180                 185                 190         
Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys
        195                 200                 205             
Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly
    210                 215                 220                 
His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln
225                 230                 235                 240 
Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg
                245                 250                 255     
Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His
            260                 265                 270         
Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln
        275                 280                 285             
Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser
    290                 295                 300                 
Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu
305                 310                 315                 320 
Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro
                325                 330                 335     
Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser
            340                 345                 350         
Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu
        355                 360                 365             
Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp
    370                 375                 380                 
Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala
385                 390                 395                 400 
Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser
                405                 410                 415     
Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly
            420                 425                 430         
Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile
        435                 440                 445             
Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln
    450                 455                 460                 
Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu
465                 470                 475                 480 
Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr
                485                 490                 495     
Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu
            500                 505                 510         
Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu
        515                 520                 525             
Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp
    530                 535                 540                 
Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu
545                 550                 555                 560 
Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile
                565                 570                 575     
Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His
            580                 585                 590         
Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys
        595                 600                 605             
Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu
    610                 615                 620                 
Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val
625                 630                 635                 640 
Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr
                645                 650                 655     
Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro
            660                 665                 670         
Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr
        675                 680                 685             
Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn
    690                 695                 700                 
Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu
705                 710                 715                 720 
Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu
                725                 730                 735     
Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro
            740                 745                 750         
Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu
        755                 760                 765             
Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala
    770                 775                 780                 
Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys
785                 790                 795                 800 
Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro
                805                 810                 815     
Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly
            820                 825                 830         
Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr
        835                 840                 845             
Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro
    850                 855                 860                 
His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu
865                 870                 875                 880 
Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg
                885                 890                 895     
Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu
            900                 905                 910         
Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu
        915                 920                 925             
Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys
    930                 935                 940                 
Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met
945                 950                 955                 960 
Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu
                965                 970                 975     
Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His
            980                 985                 990         
Asn Val Trp Ala Arg Asp Arg Val Gly Gln Gly Trp Ser Tyr Ser Ala
        995                 1000                1005            
Val Gln Asp Ile Pro Ala Arg Arg Asn Pro Arg Leu Val Pro Tyr Arg
    1010                1015                1020                
Leu Leu Asp Glu Ala Thr Lys Arg Ser Asn Arg Asp Ser Leu Cys Gln
1025                1030                1035                1040
Ala Val Arg Thr Leu Leu Gly Tyr Gly Tyr Asn Ile Glu Pro Pro Asp
                1045                1050                1055    
Gln Glu Pro Ser Gln Val Glu Asn Gln Ser Arg Cys Asp Arg Val Arg
            1060                1065                1070        
Ile Phe Arg Ala Glu Lys Ser Tyr Thr Val Gln Ser Gly Arg Trp Tyr
        1075                1080                1085            
Phe Glu Phe Glu Ala Val Thr Thr Gly Glu Met Arg Val Gly Trp Ala
    1090                1095                1100                
Arg Pro Glu Leu Arg Pro Asp Val Glu Leu Gly Ala Asp Glu Leu Ala
1105                1110                1115                1120
Tyr Val Phe Asn Gly His Arg Gly Gln Arg Trp His Leu Gly Ser Glu
                1125                1130                1135    
Pro Phe Gly Arg Pro Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile
            1140                1145                1150        
Asp Leu Thr Glu Asn Thr Ile Ile Phe Thr Leu Asn Gly Glu Val Leu
        1155                1160                1165            
Met Ser Asp Ser Gly Ser Glu Thr Ala Phe Arg Glu Ile Glu Ile Gly
    1170                1175                1180                
Asp Gly Phe Leu Pro Val Cys Ser Leu Gly Pro Gly Gln Val Gly His
1185                1190                1195                1200
Leu Asn Leu Gly Gln Asp Val Ser Ser Leu Arg Phe Phe Ala Ile Cys
                1205                1210                1215    
Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Ile Asn Met Gln Arg Pro
            1220                1225                1230        
Val Thr Thr Trp Phe Ser Lys Gly Leu Pro Gln Phe Glu Pro Val Pro
        1235                1240                1245            
Leu Glu His Pro His Tyr Glu Val Ser Arg Val Asp Gly Thr Val Asp
    1250                1255                1260                
Thr Pro Pro Cys Leu Arg Leu Thr His Arg Thr Trp Gly Ser Gln Asn
1265                1270                1275                1280
Ser Leu Val Glu Met Leu Phe Leu Arg Leu Ser Leu Pro Val Gln Phe
                1285                1290                1295    
His Gln His Phe Arg Cys Thr Ala Gly Ala Thr Pro Leu Ala Pro Pro
            1300                1305                1310        
Gly Leu Gln Pro Pro Ala Glu Asp Glu Ala Arg Ala Ala Glu Pro Asp
        1315                1320                1325            
Pro Asp Tyr Glu Asn Leu Arg Arg Ser Ala Gly Gly Trp Ser Glu Ala
    1330                1335                1340                
Glu Asn Gly Lys Glu Gly Thr Ala Lys Glu Gly Ala Pro Gly Gly Thr
1345                1350                1355                1360
Pro Gln Ala Gly Gly Glu Ala Gln Pro Ala Arg Ala Glu Asn Glu Lys
                1365                1370                1375    
Asp Ala Thr Thr Glu Lys Asn Lys Lys Arg Gly Phe Leu Phe Lys Ala
            1380                1385                1390        
Lys Lys Val Ala Met Met Thr Gln Pro Pro Ala Thr Pro Thr Leu Pro
        1395                1400                1405            
Arg Leu Pro His Asp Val Val Pro Ala Asp Asn Arg Asp Asp Pro Glu
    1410                1415                1420                
Ile Ile Leu Asn Thr Thr Thr Tyr Tyr Tyr Ser Val Arg Val Phe Ala
1425                1430                1435                1440
Gly Gln Glu Pro Ser Cys Val Trp Ala Gly Trp Val Thr Pro Asp Tyr
                1445                1450                1455    
His Gln His Asp Met Ser Phe Asp Leu Ser Lys Val Arg Val Val Thr
            1460                1465                1470        
Val Thr Met Gly Asp Glu Gln Gly Asn Val His Ser Ser Leu Lys Cys
        1475                1480                1485            
Ser Asn Cys Tyr Met Val Trp Gly Gly Asp Phe Val Ser Pro Gly Gln
    1490                1495                1500                
Gln Gly Arg Ile Ser His Thr Asp Leu Val Ile Gly Cys Leu Val Asp
1505                1510                1515                1520
Leu Ala Thr Gly Leu Met Thr Phe Thr Ala Asn Gly Lys Glu Ser Asn
                1525                1530                1535    
Thr Phe Phe Gln Val Glu Pro Asn Thr Lys Leu Phe Pro Ala Val Phe
            1540                1545                1550        
Val Leu Pro Thr His Gln Asn Val Ile Gln Phe Glu Leu Gly Lys Gln
        1555                1560                1565            
Lys Asn Ile Met Pro Leu Ser Ala Ala Met Phe Gln Ser Glu Arg Lys
    1570                1575                1580                
Asn Pro Ala Pro Gln Cys Pro Pro Arg Leu Glu Met Gln Met Leu Met
1585                1590                1595                1600
Pro Val Ser Trp Ser Arg Met Pro Asn His Phe Leu Gln Val Glu Thr
                1605                1610                1615    
Arg Arg Ala Gly Glu Arg Leu Gly Trp Ala Val Gln Cys Gln Glu Pro
            1620                1625                1630        
Leu Thr Met Met Ala Leu His Ile Pro Glu Glu Asn Arg Cys Met Asp
        1635                1640                1645            
Ile Leu Glu Leu Ser Glu Arg Leu Asp Leu Gln Arg Phe His Ser His
    1650                1655                1660                
Thr Leu Arg Leu Tyr Arg Ala Val Cys Ala Leu Gly Asn Asn Arg Val
1665                1670                1675                1680
Ala His Ala Leu Cys Ser His Val Asp Gln Ala Gln Leu Leu His Ala
                1685                1690                1695    
Leu Glu Asp Ala His Leu Pro Gly Pro Leu Arg Ala Gly Tyr Tyr Asp
            1700                1705                1710        
Leu Leu Ile Ser Ile His Leu Glu Ser Ala Cys Arg Ser Arg Arg Ser
        1715                1720                1725            
Met Leu Ser Glu Tyr Ile Val Pro Leu Thr Pro Glu Thr Arg Ala Ile
    1730                1735                1740                
Thr Leu Phe Pro Pro Gly Arg Ser Thr Glu Asn Gly His Pro Arg His
1745                1750                1755                1760
Gly Leu Pro Gly Val Gly Val Thr Thr Ser Leu Arg Pro Pro His His
                1765                1770                1775    
Phe Ser Pro Pro Cys Phe Val Ala Ala Leu Pro Ala Ala Gly Ala Ala
            1780                1785                1790        
Glu Ala Pro Ala Arg Leu Ser Pro Ala Ile Pro Leu Glu Ala Leu Arg
        1795                1800                1805            
Asp Lys Ala Leu Arg Met Leu Gly Glu Ala Val Arg Asp Gly Gly Gln
    1810                1815                1820                
His Ala Arg Asp Pro Val Gly Ala Ser Val Glu Phe Gln Phe Val Pro
1825                1830                1835                1840
Val Leu Lys Leu Val Ser Thr Leu Leu Val Met Gly Ile Phe Gly Asp
                1845                1850                1855    
Glu Asp Val Lys Gln Ile Leu Lys Met Ile Glu Pro Glu Val Phe Thr
            1860                1865                1870        
Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp
        1875                1880                1885            
Glu Glu Glu Lys Glu Glu Asp Glu Glu Glu Thr Ala Gln Glu Lys Glu
    1890                1895                1900                
Asp Glu Glu Lys Glu Glu Glu Glu Ala Ala Glu Gly Glu Lys Glu Glu
1905                1910                1915                1920
Gly Leu Glu Glu Gly Leu Leu Gln Met Lys Leu Pro Glu Ser Val Lys
                1925                1930                1935    
Leu Gln Met Cys His Leu Leu Glu Tyr Phe Cys Asp Gln Glu Leu Gln
            1940                1945                1950        
His Arg Val Glu Ser Leu Ala Ala Phe Ala Glu Arg Tyr Val Asp Lys
        1955                1960                1965            
Leu Gln Ala Asn Gln Arg Ser Arg Tyr Gly Leu Leu Ile Lys Ala Phe
    1970                1975                1980                
Ser Met Thr Ala Ala Glu Thr Ala Arg Arg Thr Arg Glu Phe Arg Ser
1985                1990                1995                2000
Pro Pro Gln Glu Gln Ile Asn Met Leu Leu Gln Phe Lys Asp Gly Thr
                2005                2010                2015    
Asp Glu Glu Asp Cys Pro Leu Pro Glu Glu Ile Arg Gln Asp Leu Leu
            2020                2025                2030        
Asp Phe His Gln Asp Leu Leu Ala His Cys Gly Ile Gln Leu Asp Gly
        2035                2040                2045            
Glu Glu Glu Glu Pro Glu Glu Glu Thr Thr Leu Gly Ser Arg Leu Met
    2050                2055                2060                
Ser Leu Leu Glu Lys Val Arg Leu Val Lys Lys Lys Glu Glu Lys Pro
2065                2070                2075                2080
Glu Glu Glu Arg Ser Ala Glu Glu Ser Lys Pro Arg Ser Leu Gln Glu
                2085                2090                2095    
Leu Val Ser His Met Val Val Arg Trp Ala Gln Glu Asp Phe Val Gln
            2100                2105                2110        
Ser Pro Glu Leu Val Arg Ala Met Phe Ser Leu Leu His Arg Gln Tyr
        2115                2120                2125            
Asp Gly Leu Gly Glu Leu Leu Arg Ala Leu Pro Arg Ala Tyr Thr Ile
    2130                2135                2140                
Ser Pro Ser Ser Val Glu Asp Thr Met Ser Leu Leu Glu Cys Leu Gly
2145                2150                2155                2160
Gln Ile Arg Ser Leu Leu Ile Val Gln Met Gly Pro Gln Glu Glu Asn
                2165                2170                2175    
Leu Met Ile Gln Ser Ile Gly Asn Ile Met Asn Asn Lys Val Phe Tyr
            2180                2185                2190        
Gln His Pro Asn Leu Met Arg Ala Leu Gly Met His Glu Thr Val Met
        2195                2200                2205            
Glu Val Met Val Asn Val Leu Gly Gly Gly Glu Ser Lys Glu Ile Arg
    2210                2215                2220                
Phe Pro Lys Met Val Thr Ser Cys Cys Arg Phe Leu Cys Tyr Phe Cys
2225                2230                2235                2240
Arg Ile Ser Arg Gln Asn Gln Arg Ser Met Phe Asp His Leu Ser Tyr
                2245                2250                2255    
Leu Leu Glu Asn Ser Gly Ile Gly Leu Gly Met Gln Gly Ser Thr Pro
            2260                2265                2270        
Leu Asp Val Ala Ala Ala Ser Val Ile Asp Asn Asn Glu Leu Ala Leu
        2275                2280                2285            
Ala Leu Gln Glu Gln Asp Leu Glu Lys Val Val Ser Tyr Leu Ala Gly
    2290                2295                2300                
Cys Gly Leu Gln Ser Cys Pro Met Leu Val Ala Lys Gly Tyr Pro Asp
2305                2310                2315                2320
Ile Gly Trp Asn Pro Cys Gly Gly Glu Arg Tyr Leu Asp Phe Leu Arg
                2325                2330                2335    
Phe Ala Val Phe Val Asn Gly Glu Ser Val Glu Glu Asn Ala Asn Val
            2340                2345                2350        
Val Val Arg Leu Leu Ile Arg Lys Pro Glu Cys Phe Gly Pro Ala Leu
        2355                2360                2365            
Arg Gly Glu Gly Gly Ser Gly Leu Leu Ala Ala Ile Glu Glu Ala Ile
    2370                2375                2380                
Arg Ile Ser Glu Asp Pro Ala Arg Asp Gly Pro Gly Ile Arg Arg Asp
2385                2390                2395                2400
Arg Arg Arg Glu His Phe Gly Glu Glu Pro Pro Glu Glu Asn Arg Val
                2405                2410                2415    
His Leu Gly His Ala Ile Met Ser Phe Tyr Ala Ala Leu Ile Asp Leu
            2420                2425                2430        
Leu Gly Arg Cys Ala Pro Glu Met His Leu Ile Gln Ala Gly Lys Gly
        2435                2440                2445            
Glu Ala Leu Arg Ile Arg Ala Ile Leu Arg Ser Leu Val Pro Leu Glu
    2450                2455                2460                
Asp Leu Val Gly Ile Ile Ser Leu Pro Leu Gln Ile Pro Thr Leu Gly
2465                2470                2475                2480
Lys Asp Gly Ala Leu Val Gln Pro Lys Met Ser Ala Ser Phe Val Pro
                2485                2490                2495    
Asp His Lys Ala Ser Met Val Leu Phe Leu Asp Arg Val Tyr Gly Ile
            2500                2505                2510        
Glu Asn Gln Asp Phe Leu Leu His Val Leu Asp Val Gly Phe Leu Pro
        2515                2520                2525            
Asp Met Arg Ala Ala Ala Ser Leu Asp Thr Ala Thr Phe Ser Thr Thr
    2530                2535                2540                
Glu Met Ala Leu Ala Val Asn Arg Tyr Leu Cys Leu Ala Val Leu Pro
2545                2550                2555                2560
Leu Ile Thr Lys Cys Ala Pro Leu Phe Ala Gly Thr Glu His Arg Ala
                2565                2570                2575    
Ile Met Val Asp Ser Met Leu His Thr Val Tyr Arg Leu Ser Arg Gly
            2580                2585                2590        
Arg Ser Leu Thr Lys Ala Gln Arg Asp Val Ile Glu Asp Cys Leu Met
        2595                2600                2605            
Ser Leu Cys Arg Tyr Ile Arg Pro Ser Met Leu Gln His Leu Leu Arg
    2610                2615                2620                
Arg Leu Val Phe Asp Val Pro Ile Leu Asn Glu Phe Ala Lys Met Pro
2625                2630                2635                2640
Leu Lys Leu Leu Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr Cys
                2645                2650                2655    
Leu Pro Thr Gly Trp Ala Asn Phe Gly Val Thr Ser Glu Glu Glu Leu
            2660                2665                2670        
His Leu Thr Arg Lys Leu Phe Trp Gly Ile Phe Asp Ser Leu Ala His
        2675                2680                2685            
Lys Lys Tyr Asp Pro Glu Leu Tyr Arg Met Ala Met Pro Cys Leu Cys
    2690                2695                2700                
Ala Ile Ala Gly Ala Leu Pro Pro Asp Tyr Val Asp Ala Ser Tyr Ser
2705                2710                2715                2720
Ser Lys Ala Glu Lys Lys Ala Thr Val Asp Ala Glu Gly Asn Phe Asp
                2725                2730                2735    
Pro Arg Pro Val Glu Thr Leu Asn Val Ile Ile Pro Glu Lys Leu Asp
            2740                2745                2750        
Ser Phe Ile Asn Lys Phe Ala Glu Tyr Thr His Glu Lys Trp Ala Phe
        2755                2760                2765            
Asp Lys Ile Gln Asn Asn Trp Ser Tyr Gly Glu Asn Ile Asp Glu Glu
    2770                2775                2780                
Leu Lys Thr His Pro Met Leu Arg Pro Tyr Lys Thr Phe Ser Glu Lys
2785                2790                2795                2800
Asp Lys Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Ala Met
                2805                2810                2815    
Ile Ala Trp Glu Trp Thr Ile Glu Lys Ala Arg Glu Gly Glu Glu Glu
            2820                2825                2830        
Lys Thr Glu Lys Lys Lys Thr Arg Lys Ile Ser Gln Ser Ala Gln Thr
        2835                2840                2845            
Tyr Asp Pro Arg Glu Gly Tyr Asn Pro Gln Pro Pro Asp Leu Ser Ala
    2850                2855                2860                
Val Thr Leu Ser Arg Glu Leu Gln Ala Met Ala Glu Gln Leu Ala Glu
2865                2870                2875                2880
Asn Tyr His Asn Thr Trp Gly Arg Lys Lys Lys Gln Glu Leu Glu Ala
                2885                2890                2895    
Lys Gly Gly Gly Thr His Pro Leu Leu Val Pro Tyr Asp Thr Leu Thr
            2900                2905                2910        
Ala Lys Glu Lys Ala Arg Asp Arg Glu Lys Ala Gln Glu Leu Leu Lys
        2915                2920                2925            
Phe Leu Gln Met Asn Gly Tyr Ala Val Thr Arg Gly Leu Lys Asp Met
    2930                2935                2940                
Glu Leu Asp Ser Ser Ser Ile Glu Lys Arg Phe Ala Phe Gly Phe Leu
2945                2950                2955                2960
Gln Gln Leu Leu Arg Trp Met Asp Ile Ser Gln Glu Phe Ile Ala His
                2965                2970                2975    
Leu Glu Ala Val Val Ser Ser Gly Arg Val Glu Lys Ser Pro His Glu
            2980                2985                2990        
Gln Glu Ile Lys Phe Phe Ala Lys Ile Leu Leu Pro Leu Ile Asn Gln
        2995                3000                3005            
Tyr Phe Thr Asn His Cys Leu Tyr Phe Leu Ser Thr Pro Ala Lys Val
    3010                3015                3020                
Leu Gly Ser Gly Gly His Ala Ser Asn Lys Glu Lys Glu Met Ile Thr
3025                3030                3035                3040
Ser Leu Phe Cys Lys Leu Ala Ala Leu Val Arg His Arg Val Ser Leu
                3045                3050                3055    
Phe Gly Thr Asp Ala Pro Ala Val Val Asn Cys Leu His Ile Leu Ala
            3060                3065                3070        
Arg Ser Leu Asp Ala Arg Thr Val Met Lys Ser Gly Pro Glu Ile Val
        3075                3080                3085            
Lys Ala Gly Leu Arg Ser Phe Phe Glu Ser Ala Ser Glu Asp Ile Glu
    3090                3095                3100                
Lys Met Val Glu Asn Leu Arg Leu Gly Lys Val Ser Gln Ala Arg Thr
3105                3110                3115                3120
Gln Val Lys Gly Val Gly Gln Asn Leu Thr Tyr Thr Thr Val Ala Leu
                3125                3130                3135    
Leu Pro Val Leu Thr Thr Leu Phe Gln His Ile Ala Gln His Gln Phe
            3140                3145                3150        
Gly Asp Asp Val Ile Leu Asp Asp Val Gln Val Ser Cys Tyr Arg Thr
        3155                3160                3165            
Leu Cys Ser Ile Tyr Ser Leu Gly Thr Thr Lys Asn Thr Tyr Val Glu
    3170                3175                3180                
Lys Leu Arg Pro Ala Leu Gly Glu Cys Leu Ala Arg Leu Ala Ala Ala
3185                3190                3195                3200
Met Pro Val Ala Phe Leu Glu Pro Gln Leu Asn Glu Tyr Asn Ala Cys
                3205                3210                3215    
Ser Val Tyr Thr Thr Lys Ser Pro Arg Glu Arg Ala Ile Leu Gly Leu
            3220                3225                3230        
Pro Asn Ser Val Glu Glu Met Cys Pro Asp Ile Pro Val Leu Glu Arg
        3235                3240                3245            
Leu Met Ala Asp Ile Gly Gly Leu Ala Glu Ser Gly Ala Arg Tyr Thr
    3250                3255                3260                
Glu Met Pro His Val Ile Glu Ile Thr Leu Pro Met Leu Cys Ser Tyr
3265                3270                3275                3280
Leu Pro Arg Trp Trp Glu Arg Gly Pro Glu Ala Pro Pro Ser Ala Leu
                3285                3290                3295    
Pro Ala Gly Ala Pro Pro Pro Cys Thr Ala Val Thr Ser Asp His Leu
            3300                3305                3310        
Asn Ser Leu Leu Gly Asn Ile Leu Arg Ile Ile Val Asn Asn Leu Gly
        3315                3320                3325            
Ile Asp Glu Ala Ser Trp Met Lys Arg Leu Ala Val Phe Ala Gln Pro
    3330                3335                3340                
Ile Val Ser Arg Ala Arg Pro Glu Leu Leu Gln Ser His Phe Ile Pro
3345                3350                3355                3360
Thr Ile Gly Arg Leu Arg Lys Arg Ala Gly Lys Val Val Ser Glu Glu
                3365                3370                3375    
Glu Gln Leu Arg Leu Glu Ala Lys Ala Glu Ala Gln Glu Gly Glu Leu
            3380                3385                3390        
Leu Val Arg Asp Glu Phe Ser Val Leu Cys Arg Asp Leu Tyr Ala Leu
        3395                3400                3405            
Tyr Pro Leu Leu Ile Arg Tyr Val Asp Asn Asn Arg Ala Gln Trp Leu
    3410                3415                3420                
Thr Glu Pro Asn Pro Ser Ala Glu Glu Leu Phe Arg Met Val Gly Glu
3425                3430                3435                3440
Ile Phe Ile Tyr Trp Ser Lys Ser His Asn Phe Lys Arg Glu Glu Gln
                3445                3450                3455    
Asn Phe Val Val Gln Asn Glu Ile Asn Asn Met Ser Phe Leu Thr Ala
            3460                3465                3470        
Asp Asn Lys Ser Lys Met Ala Lys Ser Gly Gly Ser Asp Gln Glu Arg
        3475                3480                3485            
Thr Lys Lys Lys Arg Arg Gly Asp Arg Tyr Ser Val Gln Thr Ser Leu
    3490                3495                3500                
Ile Val Ala Thr Leu Lys Lys Met Leu Pro Ile Gly Leu Asn Met Cys
3505                3510                3515                3520
Ala Pro Thr Asp Gln Asp Leu Ile Thr Leu Ala Lys Thr Arg Tyr Ala
                3525                3530                3535    
Leu Lys Asp Thr Asp Glu Glu Val Arg Glu Phe Leu His Asn Asn Leu
            3540                3545                3550        
His Leu Gln Gly Lys Val Glu Gly Ser Pro Ser Leu Arg Trp Gln Met
        3555                3560                3565            
Ala Leu Tyr Arg Gly Val Pro Gly Arg Glu Glu Asp Ala Asp Asp Pro
    3570                3575                3580                
Glu Lys Ile Val Arg Arg Val Gln Glu Val Ser Ala Val Leu Tyr Tyr
3585                3590                3595                3600
Leu Asp Gln Thr Glu His Pro Tyr Lys Ser Lys Lys Ala Val Trp His
                3605                3610                3615    
Lys Leu Leu Ser Lys Gln Arg Arg Arg Ala Val Val Ala Cys Phe Arg
            3620                3625                3630        
Met Thr Pro Leu Tyr Asn Leu Pro Thr His Arg Ala Cys Asn Met Phe
        3635                3640                3645            
Leu Glu Ser Tyr Lys Ala Ala Trp Ile Leu Thr Glu Asp His Ser Phe
    3650                3655                3660                
Glu Asp Arg Met Ile Asp Asp Leu Ser Lys Ala Gly Glu Gln Glu Glu
3665                3670                3675                3680
Glu Glu Glu Glu Val Glu Glu Lys Lys Pro Asp Pro Leu His Gln Leu
                3685                3690                3695    
Val Leu His Phe Ser Arg Thr Ala Leu Thr Glu Lys Ser Lys Leu Asp
            3700                3705                3710        
Glu Asp Tyr Leu Tyr Met Ala Tyr Ala Asp Ile Met Ala Lys Ser Cys
        3715                3720                3725            
His Leu Glu Glu Gly Gly Glu Asn Gly Glu Ala Glu Glu Glu Val Glu
    3730                3735                3740                
Val Ser Phe Glu Glu Lys Gln Met Glu Lys Gln Arg Leu Leu Tyr Gln
3745                3750                3755                3760
Gln Ala Arg Leu His Thr Arg Gly Ala Ala Glu Met Val Leu Gln Met
                3765                3770                3775    
Ile Ser Ala Cys Lys Gly Glu Thr Gly Ala Met Val Ser Ser Thr Leu
            3780                3785                3790        
Lys Leu Gly Ile Ser Ile Leu Asn Gly Gly Asn Ala Glu Val Gln Gln
        3795                3800                3805            
Lys Met Leu Asp Tyr Leu Lys Asp Lys Lys Glu Val Gly Phe Phe Gln
    3810                3815                3820                
Ser Ile Gln Ala Leu Met Gln Thr Cys Ser Val Leu Asp Leu Asn Ala
3825                3830                3835                3840
Phe Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly Met Val Asn Glu Asp
                3845                3850                3855    
Gly Thr Val Ile Asn Arg Gln Asn Gly Glu Lys Val Met Ala Asp Asp
            3860                3865                3870        
Glu Phe Thr Gln Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu Gly
        3875                3880                3885            
His Asn Asn Asp Phe Gln Asn Tyr Leu Arg Thr Gln Thr Gly Asn Thr
    3890                3895                3900                
Thr Thr Ile Asn Ile Ile Ile Cys Thr Val Asp Tyr Leu Leu Arg Leu
3905                3910                3915                3920
Gln Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp Val
                3925                3930                3935    
Ile Glu Glu Gln Gly Lys Arg Asn Phe Ser Lys Ala Met Ser Val Ala
            3940                3945                3950        
Lys Gln Val Phe Asn Ser Leu Thr Glu Tyr Ile Gln Gly Pro Cys Thr
        3955                3960                3965            
Gly Asn Gln Gln Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val Val
    3970                3975                3980                
Gly Phe Leu His Val Phe Ala His Met Met Met Lys Leu Ala Gln Asp
3985                3990                3995                4000
Ser Ser Gln Ile Glu Leu Leu Lys Glu Leu Leu Asp Leu Gln Lys Asp
                4005                4010                4015    
Met Val Val Met Leu Leu Ser Leu Leu Glu Gly Asn Val Val Asn Gly
            4020                4025                4030        
Met Ile Ala Arg Gln Met Val Asp Met Leu Val Glu Ser Ser Ser Asn
        4035                4040                4045            
Val Glu Met Ile Leu Lys Phe Phe Asp Met Phe Leu Lys Leu Lys Asp
    4050                4055                4060                
Ile Val Gly Ser Glu Ala Phe Gln Asp Tyr Val Thr Asp Pro Arg Gly
4065                4070                4075                4080
Leu Ile Ser Lys Lys Asp Phe Gln Lys Ala Met Asp Ser Gln Lys Gln
                4085                4090                4095    
Phe Ser Gly Pro Glu Ile Gln Phe Leu Leu Ser Cys Ser Glu Ala Asp
            4100                4105                4110        
Glu Asn Glu Met Ile Asn Cys Glu Glu Phe Ala Asn Arg Phe Gln Glu
        4115                4120                4125            
Pro Ala Arg Asp Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn Leu
    4130                4135                4140                
Ser Glu His Val Pro His Asp Pro Arg Leu His Asn Phe Leu Glu Leu
4145                4150                4155                4160
Ala Glu Ser Ile Leu Glu Tyr Phe Arg Pro Tyr Leu Gly Arg Ile Glu
                4165                4170                4175    
Ile Met Gly Ala Ser Arg Arg Ile Glu Arg Ile Tyr Phe Glu Ile Ser
            4180                4185                4190        
Glu Thr Asn Arg Ala Gln Trp Glu Met Pro Gln Val Lys Glu Ser Lys
        4195                4200                4205            
Arg Gln Phe Ile Phe Asp Val Val Asn Glu Gly Gly Glu Ala Glu Lys
    4210                4215                4220                
Met Glu Leu Phe Val Ser Phe Cys Glu Asp Thr Ile Phe Glu Met Gln
4225                4230                4235                4240
Ile Ala Ala Gln Ile Ser Glu Pro Glu Gly Glu Pro Glu Thr Asp Glu
                4245                4250                4255    
Asp Glu Gly Ala Gly Ala Ala Glu Ala Gly Ala Glu Gly Ala Glu Glu
            4260                4265                4270        
Gly Ala Ala Gly Leu Glu Gly Thr Ala Ala Thr Ala Ala Ala Gly Ala
        4275                4280                4285            
Thr Ala Arg Val Val Ala Ala Ala Gly Arg Ala Leu Arg Gly Leu Ser
    4290                4295                4300                
Tyr Arg Ser Leu Arg Arg Arg Val Arg Arg Leu Arg Arg Leu Thr Ala
4305                4310                4315                4320
Arg Glu Ala Ala Thr Ala Val Ala Ala Leu Leu Trp Ala Ala Val Thr
                4325                4330                4335    
Arg Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly Ala Leu Gly Leu
            4340                4345                4350        
Leu Trp Gly Ser Leu Phe Gly Gly Gly Leu Val Glu Gly Ala Lys Lys
        4355                4360                4365            
Val Thr Val Thr Glu Leu Leu Ala Gly Met Pro Asp Pro Thr Ser Asp
    4370                4375                4380                
Glu Val His Gly Glu Gln Pro Ala Gly Pro Gly Gly Asp Ala Asp Gly
4385                4390                4395                4400
Glu Gly Ala Ser Glu Gly Ala Gly Asp Ala Ala Glu Gly Ala Gly Asp
                4405                4410                4415    
Glu Glu Glu Ala Val His Glu Ala Gly Pro Gly Gly Ala Asp Gly Ala
            4420                4425                4430        
Val Ala Val Thr Asp Gly Gly Pro Phe Arg Pro Glu Gly Ala Gly Gly
        4435                4440                4445            
Leu Gly Asp Met Gly Asp Thr Thr Pro Ala Glu Pro Pro Thr Pro Glu
    4450                4455                4460                
Gly Ser Pro Ile Leu Lys Arg Lys Leu Gly Val Asp Gly Val Glu Glu
4465                4470                4475                4480
Glu Leu Pro Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu Pro
                4485                4490                4495    
Glu Lys Ala Asp Ala Glu Asn Gly Glu Lys Glu Glu Val Pro Glu Pro
            4500                4505                4510        
Thr Pro Glu Pro Pro Lys Lys Gln Ala Pro Pro Ser Pro Pro Pro Lys
        4515                4520                4525            
Lys Glu Glu Ala Gly Gly Glu Phe Trp Gly Glu Leu Glu Val Gln Arg
    4530                4535                4540                
Val Lys Phe Leu Asn Tyr Leu Ser Arg Asn Phe Tyr Thr Leu Arg Phe
4545                4550                4555                4560
Leu Ala Leu Phe Leu Ala Phe Ala Ile Asn Phe Ile Leu Leu Phe Tyr
                4565                4570                4575    
Lys Val Ser Asp Ser Pro Pro Gly Glu Asp Asp Met Glu Gly Ser Ala
            4580                4585                4590        
Ala Gly Asp Val Ser Gly Ala Gly Ser Gly Gly Ser Ser Gly Trp Gly
        4595                4600                4605            
Leu Gly Ala Gly Glu Glu Ala Glu Gly Asp Glu Asp Glu Asn Met Val
    4610                4615                4620                
Tyr Tyr Phe Leu Glu Glu Ser Thr Gly Tyr Met Glu Pro Ala Leu Arg
4625                4630                4635                4640
Cys Leu Ser Leu Leu His Thr Leu Val Ala Phe Leu Cys Ile Ile Gly
                4645                4650                4655    
Tyr Asn Cys Leu Lys Val Pro Leu Val Ile Phe Lys Arg Glu Lys Glu
            4660                4665                4670        
Leu Ala Arg Lys Leu Glu Phe Asp Gly Leu Tyr Ile Thr Glu Gln Pro
        4675                4680                4685            
Glu Asp Asp Asp Val Lys Gly Gln Trp Asp Arg Leu Val Leu Asn Thr
    4690                4695                4700                
Pro Ser Phe Pro Ser Asn Tyr Trp Asp Lys Phe Val Lys Arg Lys Val
4705                4710                4715                4720
Leu Asp Lys His Gly Asp Ile Tyr Gly Arg Glu Arg Ile Ala Glu Leu
                4725                4730                4735    
Leu Gly Met Asp Leu Ala Thr Leu Glu Ile Thr Ala His Asn Glu Arg
            4740                4745                4750        
Lys Pro Asn Pro Pro Pro Gly Leu Leu Thr Trp Leu Met Ser Ile Asp
        4755                4760                4765            
Val Lys Tyr Gln Ile Trp Lys Phe Gly Val Ile Phe Thr Asp Asn Ser
    4770                4775                4780                
Phe Leu Tyr Leu Gly Trp Tyr Met Val Met Ser Leu Leu Gly His Tyr
4785                4790                4795                4800
Asn Asn Phe Phe Phe Ala Ala His Leu Leu Asp Ile Ala Met Gly Val
                4805                4810                4815    
Lys Thr Leu Arg Thr Ile Leu Ser Ser Val Thr His Asn Gly Lys Gln
            4820                4825                4830        
Leu Val Met Thr Val Gly Leu Leu Ala Val Val Val Tyr Leu Tyr Thr
        4835                4840                4845            
Val Val Ala Phe Asn Phe Phe Arg Lys Phe Tyr Asn Lys Ser Glu Asp
    4850                4855                4860                
Glu Asp Glu Pro Asp Met Lys Cys Asp Asp Met Met Thr Cys Tyr Leu
4865                4870                4875                4880
Phe His Met Tyr Val Gly Val Arg Ala Gly Gly Gly Ile Gly Asp Glu
                4885                4890                4895    
Ile Glu Asp Pro Ala Gly Asp Glu Tyr Glu Leu Tyr Arg Val Val Phe
            4900                4905                4910        
Asp Ile Thr Phe Phe Phe Phe Val Ile Val Ile Leu Leu Ala Ile Ile
        4915                4920                4925            
Gln Gly Leu Ile Ile Asp Ala Phe Gly Glu Leu Arg Asp Gln Gln Glu
    4930                4935                4940                
Gln Val Lys Glu Asp Met Glu Thr Lys Cys Phe Ile Cys Gly Ile Gly
4945                4950                4955                4960
Ser Asp Tyr Phe Asp Thr Thr Pro His Gly Phe Glu Thr His Thr Leu
                4965                4970                4975    
Glu Glu His Asn Leu Ala Asn Tyr Met Phe Phe Leu Met Tyr Leu Ile
            4980                4985                4990        
Asn Lys Asp Glu Thr Glu His Thr Gly Gln Glu Ser Tyr Val Trp Lys
        4995                5000                5005            
Met Tyr Gln Glu Arg Cys Trp Asp Phe Phe Pro Ala Gly Asp Cys Phe
    5010                5015                5020                
Arg Lys Gln Tyr Glu Asp Gln Leu Ser
5025                5030            


<210> 9376
<211> 712
<212> PRT
<213> Homo sapiens

<400> 9376
Met Asp Thr Ser Ser Lys Glu Asn Ile Gln Leu Phe Cys Lys Thr Ser
 1               5                  10                  15      
Val Gln Pro Val Gly Arg Pro Ser Phe Lys Thr Glu Tyr Pro Ser Ser
            20                  25                  30          
Glu Glu Lys Gln Pro Cys Cys Gly Glu Leu Lys Val Phe Leu Cys Ala
        35                  40                  45              
Leu Ser Phe Val Tyr Phe Ala Lys Ala Leu Ala Glu Gly Tyr Leu Lys
    50                  55                  60                  
Ser Thr Ile Thr Gln Ile Glu Arg Arg Phe Asp Ile Pro Ser Ser Leu
65                  70                  75                  80  
Val Gly Val Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val Ile
                85                  90                  95      
Thr Phe Val Ser Tyr Phe Gly Ala Lys Leu His Arg Pro Lys Ile Ile
            100                 105                 110         
Gly Ala Gly Cys Val Ile Met Gly Val Gly Thr Leu Leu Ile Ala Met
        115                 120                 125             
Pro Gln Phe Phe Met Glu Gln Tyr Lys Tyr Glu Arg Tyr Ser Pro Ser
    130                 135                 140                 
Ser Asn Ser Thr Leu Ser Ile Ser Pro Cys Leu Leu Glu Ser Ser Ser
145                 150                 155                 160 
Gln Leu Pro Val Ser Val Met Glu Lys Ser Lys Ser Lys Ile Ser Asn
                165                 170                 175     
Glu Cys Glu Val Asp Thr Ser Ser Ser Met Trp Ile Tyr Val Phe Leu
            180                 185                 190         
Gly Asn Leu Leu Arg Gly Ile Gly Glu Thr Pro Ile Gln Pro Leu Gly
        195                 200                 205             
Ile Ala Tyr Leu Asp Asp Phe Ala Ser Glu Asp Asn Ala Ala Phe Tyr
    210                 215                 220                 
Ile Gly Cys Val Gln Thr Val Ala Ile Ile Gly Pro Ile Phe Gly Phe
225                 230                 235                 240 
Leu Leu Gly Ser Leu Cys Ala Lys Leu Tyr Val Asp Ile Gly Phe Val
                245                 250                 255     
Asn Leu Asp His Ile Thr Ile Thr Pro Lys Asp Pro Gln Trp Val Gly
            260                 265                 270         
Ala Trp Trp Leu Gly Tyr Leu Ile Ala Gly Ile Ile Ser Leu Leu Ala
        275                 280                 285             
Ala Val Pro Phe Trp Tyr Leu Pro Lys Ser Leu Pro Arg Ser Gln Ser
    290                 295                 300                 
Arg Glu Asp Ser Asn Ser Ser Ser Glu Lys Ser Lys Phe Ile Ile Asp
305                 310                 315                 320 
Asp His Thr Asp Tyr Gln Thr Pro Gln Gly Glu Asn Ala Lys Ile Met
                325                 330                 335     
Glu Met Ala Arg Asp Phe Leu Pro Ser Leu Lys Asn Leu Phe Gly Asn
            340                 345                 350         
Pro Val Tyr Phe Leu Tyr Leu Cys Thr Ser Thr Val Gln Phe Asn Ser
        355                 360                 365             
Leu Phe Gly Met Val Thr Tyr Lys Pro Lys Tyr Ile Glu Gln Gln Tyr
    370                 375                 380                 
Gly Gln Ser Ser Ser Arg Ala Asn Phe Val Ile Gly Leu Ile Asn Ile
385                 390                 395                 400 
Pro Ala Val Ala Leu Gly Ile Phe Ser Gly Gly Ile Val Met Lys Lys
                405                 410                 415     
Phe Arg Ile Ser Val Cys Gly Ala Ala Lys Leu Tyr Leu Gly Ser Ser
            420                 425                 430         
Val Phe Gly Tyr Leu Leu Phe Leu Ser Leu Phe Ala Leu Gly Cys Glu
        435                 440                 445             
Asn Ser Asp Val Ala Gly Leu Thr Val Ser Tyr Gln Gly Thr Lys Pro
    450                 455                 460                 
Val Ser Tyr His Glu Arg Ala Leu Phe Ser Asp Cys Asn Ser Arg Cys
465                 470                 475                 480 
Lys Cys Ser Glu Thr Lys Trp Glu Pro Met Cys Gly Glu Asn Gly Ile
                485                 490                 495     
Thr Tyr Val Ser Ala Cys Leu Ala Gly Cys Gln Thr Ser Asn Arg Ser
            500                 505                 510         
Gly Lys Asn Ile Ile Phe Tyr Asn Cys Thr Cys Val Gly Ile Ala Ala
        515                 520                 525             
Ser Lys Ser Gly Asn Ser Ser Gly Ile Val Gly Arg Cys Gln Lys Asp
    530                 535                 540                 
Asn Gly Cys Pro Gln Met Phe Leu Tyr Phe Leu Val Ile Ser Val Ile
545                 550                 555                 560 
Thr Ser Tyr Thr Leu Ser Leu Gly Gly Ile Pro Gly Tyr Ile Leu Leu
                565                 570                 575     
Leu Arg Cys Ile Lys Pro Gln Leu Lys Ser Phe Ala Leu Gly Ile Tyr
            580                 585                 590         
Thr Leu Ala Ile Arg Val Leu Ala Gly Ile Pro Ala Pro Val Tyr Phe
        595                 600                 605             
Gly Val Leu Ile Asp Thr Ser Cys Leu Lys Trp Gly Phe Lys Arg Cys
    610                 615                 620                 
Gly Ser Arg Gly Ser Cys Arg Leu Tyr Asp Ser Asn Val Phe Arg His
625                 630                 635                 640 
Ile Tyr Leu Gly Leu Thr Val Ile Leu Gly Thr Val Ser Ile Leu Leu
                645                 650                 655     
Ser Ile Ala Val Leu Phe Ile Leu Lys Lys Asn Tyr Val Ser Lys His
            660                 665                 670         
Arg Ser Phe Ile Thr Lys Arg Glu Arg Thr Met Val Ser Thr Arg Phe
        675                 680                 685             
Gln Lys Glu Asn Tyr Thr Thr Ser Asp His Leu Leu Gln Pro Asn Tyr
    690                 695                 700                 
Trp Pro Gly Lys Glu Thr Gln Leu
705                 710         


<210> 9377
<211> 313
<212> PRT
<213> Homo sapiens

<400> 9377
Met Glu Gly Lys Asn Leu Thr Ser Ile Ser Glu Cys Phe Leu Leu Gly
 1               5                  10                  15      
Phe Ser Glu Gln Leu Glu Glu Gln Lys Pro Leu Phe Gly Ser Phe Leu
            20                  25                  30          
Phe Met Tyr Leu Val Thr Val Ala Gly Asn Leu Leu Ile Ile Leu Val
        35                  40                  45              
Ile Ile Thr Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ala
    50                  55                  60                  
Asn Leu Ser Leu Ala Asp Ala Cys Phe Val Ser Thr Thr Val Pro Lys
65                  70                  75                  80  
Met Leu Ala Asn Ile Gln Ile Gln Ser Gln Ala Ile Ser Tyr Ser Gly
                85                  90                  95      
Cys Leu Leu Gln Leu Tyr Phe Phe Met Leu Phe Val Met Leu Glu Ala
            100                 105                 110         
Phe Leu Leu Ala Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys His
        115                 120                 125             
Pro Leu His Tyr Ile Leu Ile Met Ser Pro Gly Leu Cys Ile Phe Leu
    130                 135                 140                 
Val Ser Ala Ser Trp Ile Met Asn Ala Leu His Ser Leu Leu His Thr
145                 150                 155                 160 
Leu Leu Met Asn Ser Leu Ser Phe Cys Ala Asn His Glu Ile Pro His
                165                 170                 175     
Phe Phe Cys Asp Ile Asn Pro Leu Leu Ser Leu Ser Cys Thr Asp Pro
            180                 185                 190         
Phe Thr Asn Glu Leu Val Ile Phe Ile Thr Gly Gly Leu Thr Gly Leu
        195                 200                 205             
Ile Cys Val Leu Cys Leu Ile Ile Ser Tyr Thr Asn Val Phe Ser Thr
    210                 215                 220                 
Ile Leu Lys Ile Pro Ser Ala Gln Gly Lys Arg Lys Ala Phe Ser Thr
225                 230                 235                 240 
Cys Ser Ser His Leu Ser Val Val Ser Leu Phe Phe Gly Thr Ser Phe
                245                 250                 255     
Cys Val Asp Phe Ser Ser Pro Ser Thr His Ser Ala Gln Lys Asp Thr
            260                 265                 270         
Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe
        275                 280                 285             
Ile Tyr Ser Leu Arg Asn Gln Glu Ile Lys Ser Ser Leu Arg Lys Leu
    290                 295                 300                 
Ile Trp Val Arg Lys Ile His Ser Pro
305                 310             


<210> 9378
<211> 882
<212> PRT
<213> Homo sapiens

<400> 9378
Met Pro Ala Leu Ala Cys Leu Arg Arg Leu Cys Arg His Val Ser Pro
 1               5                  10                  15      
Gln Ala Val Leu Phe Leu Leu Phe Ile Phe Cys Leu Phe Ser Val Phe
            20                  25                  30          
Ile Ser Ala Tyr Tyr Leu Tyr Gly Trp Lys Arg Gly Leu Glu Pro Ser
        35                  40                  45              
Ala Asp Ala Pro Glu Pro Asp Cys Gly Asp Pro Pro Pro Val Ala Pro
    50                  55                  60                  
Ser Arg Leu Leu Pro Leu Lys Pro Val Gln Ala Ala Thr Pro Ser Arg
65                  70                  75                  80  
Thr Asp Pro Leu Val Leu Val Phe Val Glu Ser Leu Tyr Ser Gln Leu
                85                  90                  95      
Gly Gln Glu Val Val Ala Ile Leu Glu Ser Ser Arg Phe Lys Tyr Arg
            100                 105                 110         
Thr Glu Ile Ala Pro Gly Lys Gly Asp Met Pro Thr Leu Thr Asp Lys
        115                 120                 125             
Gly Arg Gly Arg Phe Ala Leu Ile Ile Tyr Glu Asn Ile Leu Lys Tyr
    130                 135                 140                 
Val Asn Leu Asp Ala Trp Asn Arg Glu Leu Leu Asp Lys Tyr Cys Val
145                 150                 155                 160 
Ala Tyr Gly Val Gly Ile Ile Gly Phe Phe Lys Ala Asn Glu Asn Ser
                165                 170                 175     
Leu Leu Ser Ala Gln Leu Lys Gly Phe Pro Leu Phe Leu His Ser Asn
            180                 185                 190         
Leu Gly Leu Lys Asp Cys Ser Ile Asn Pro Lys Ser Pro Leu Leu Tyr
        195                 200                 205             
Val Thr Arg Pro Ser Glu Val Glu Lys Gly Val Leu Pro Gly Glu Asp
    210                 215                 220                 
Trp Thr Val Phe Gln Ser Asn His Ser Thr Tyr Glu Pro Val Leu Leu
225                 230                 235                 240 
Ala Lys Thr Arg Ser Ser Glu Ser Ile Pro His Leu Gly Ala Asp Ala
                245                 250                 255     
Gly Leu His Ala Ala Leu His Ala Thr Val Val Gln Asp Leu Gly Leu
            260                 265                 270         
His Asp Gly Ile Gln Arg Val Leu Phe Gly Asn Asn Leu Asn Phe Trp
        275                 280                 285             
Leu His Lys Leu Val Phe Val Asp Ala Val Ala Phe Leu Thr Gly Lys
    290                 295                 300                 
Arg Leu Ser Leu Pro Leu Asp Arg Tyr Ile Leu Val Asp Ile Asp Asp
305                 310                 315                 320 
Ile Phe Val Gly Lys Glu Gly Thr Arg Met Lys Val Glu Asp Val Lys
                325                 330                 335     
Ala Leu Phe Asp Thr Gln Asn Glu Leu Arg Ala His Ile Pro Asn Phe
            340                 345                 350         
Thr Phe Asn Leu Gly Tyr Ser Gly Lys Phe Phe His Thr Gly Thr Asn
        355                 360                 365             
Ala Glu Asp Ala Gly Asp Asp Leu Leu Leu Ser Tyr Val Lys Glu Phe
    370                 375                 380                 
Trp Trp Phe Pro His Met Trp Ser His Met Gln Pro His Leu Phe His
385                 390                 395                 400 
Asn Gln Ser Val Leu Ala Glu Gln Met Ala Leu Asn Lys Lys Phe Ala
                405                 410                 415     
Val Glu His Gly Ile Pro Thr Asp Met Gly Tyr Ala Val Ala Pro His
            420                 425                 430         
His Ser Gly Val Tyr Pro Val His Val Gln Leu Tyr Glu Ala Trp Lys
        435                 440                 445             
Gln Val Trp Ser Ile Arg Val Thr Ser Thr Glu Glu Tyr Pro His Leu
    450                 455                 460                 
Lys Pro Ala Arg Tyr Arg Arg Gly Phe Ile His Asn Gly Ile Met Val
465                 470                 475                 480 
Leu Pro Arg Gln Thr Cys Gly Leu Phe Thr His Thr Ile Phe Tyr Asn
                485                 490                 495     
Glu Tyr Pro Gly Gly Ser Ser Glu Leu Asp Lys Ile Ile Asn Gly Gly
            500                 505                 510         
Glu Leu Phe Leu Thr Val Leu Leu Asn Pro Ile Ser Ile Phe Met Thr
        515                 520                 525             
His Leu Ser Asn Tyr Gly Asn Asp Arg Leu Gly Leu Tyr Thr Phe Lys
    530                 535                 540                 
His Leu Val Arg Phe Leu His Ser Trp Thr Asn Leu Arg Leu Gln Thr
545                 550                 555                 560 
Leu Pro Pro Val Gln Leu Ala Gln Lys Tyr Phe Gln Ile Phe Ser Glu
                565                 570                 575     
Glu Lys Asp Pro Leu Trp Gln Asp Pro Cys Glu Asp Lys Arg His Lys
            580                 585                 590         
Asp Ile Trp Ser Lys Glu Lys Thr Cys Asp Arg Phe Pro Lys Leu Leu
        595                 600                 605             
Ile Ile Gly Pro Gln Lys Thr Gly Thr Thr Ala Leu Tyr Leu Phe Leu
    610                 615                 620                 
Gly Met His Pro Asp Leu Ser Ser Asn Tyr Pro Ser Ser Glu Thr Phe
625                 630                 635                 640 
Glu Glu Ile Gln Phe Phe Asn Gly His Asn Tyr His Lys Gly Ile Asp
                645                 650                 655     
Trp Tyr Met Glu Phe Phe Pro Ile Pro Ser Asn Thr Thr Ser Asp Phe
            660                 665                 670         
Tyr Phe Glu Lys Ser Ala Asn Tyr Phe Asp Ser Glu Val Ala Pro Arg
        675                 680                 685             
Arg Ala Ala Ala Leu Leu Pro Lys Ala Lys Val Leu Thr Ile Leu Ile
    690                 695                 700                 
Asn Pro Ala Asp Arg Ala Tyr Ser Trp Tyr Gln His Gln Arg Ala His
705                 710                 715                 720 
Asp Asp Pro Val Ala Leu Lys Tyr Thr Phe His Glu Val Ile Thr Ala
                725                 730                 735     
Gly Ser Asp Ala Ser Ser Lys Leu Arg Ala Leu Gln Asn Arg Cys Leu
            740                 745                 750         
Val Pro Gly Trp Tyr Ala Thr His Ile Glu Arg Trp Leu Ser Ala Tyr
        755                 760                 765             
His Ala Asn Gln Ile Leu Val Leu Asp Gly Lys Leu Leu Arg Thr Glu
    770                 775                 780                 
Pro Ala Lys Val Met Asp Met Val Gln Lys Phe Leu Gly Val Thr Asn
785                 790                 795                 800 
Thr Ile Asp Tyr His Lys Thr Leu Ala Phe Asp Pro Lys Lys Gly Phe
                805                 810                 815     
Trp Cys Gln Leu Leu Glu Gly Gly Lys Thr Lys Cys Leu Gly Lys Ser
            820                 825                 830         
Lys Gly Arg Lys Tyr Pro Glu Met Asp Leu Asp Ser Arg Ala Phe Leu
        835                 840                 845             
Lys Asp Tyr Tyr Arg Asp His Asn Ile Glu Leu Ser Lys Leu Leu Tyr
    850                 855                 860                 
Lys Met Gly Gln Thr Leu Pro Thr Trp Leu Arg Glu Asp Leu Gln Asn
865                 870                 875                 880 
Thr Arg
        


<210> 9379
<211> 556
<212> PRT
<213> Homo sapiens

<400> 9379
Met Pro Ala Leu Ala Cys Leu Arg Arg Leu Cys Arg His Val Ser Pro
 1               5                  10                  15      
Gln Ala Val Leu Phe Leu Leu Gln Val Val Cys Gln Phe Ser Val Phe
            20                  25                  30          
Ile Ser Ala Tyr Tyr Leu Tyr Gly Trp Lys Arg Gly Leu Glu Pro Ser
        35                  40                  45              
Ala Asp Ala Pro Glu Pro Asp Cys Gly Asp Pro Pro Pro Val Ala Pro
    50                  55                  60                  
Ser Arg Leu Leu Pro Leu Lys Pro Val Gln Ala Ala Thr Pro Ser Arg
65                  70                  75                  80  
Thr Asp Pro Leu Val Leu Val Phe Val Glu Ser Leu Tyr Ser Gln Leu
                85                  90                  95      
Gly Gln Glu Val Val Ala Ile Leu Glu Ser Ser Arg Phe Lys Tyr Arg
            100                 105                 110         
Thr Glu Ile Ala Pro Gly Lys Gly Asp Met Pro Thr Leu Thr Asp Lys
        115                 120                 125             
Gly Arg Gly Arg Phe Ala Leu Ile Ile Tyr Glu Asn Ile Leu Lys Tyr
    130                 135                 140                 
Val Asn Leu Asp Ala Trp Asn Arg Glu Leu Leu Asp Lys Tyr Cys Val
145                 150                 155                 160 
Ala Tyr Gly Val Gly Ile Ile Gly Phe Phe Lys Ala Asn Glu Asn Ser
                165                 170                 175     
Leu Leu Ser Ala Gln Leu Lys Gly Phe Pro Leu Phe Leu His Ser Asn
            180                 185                 190         
Leu Gly Leu Lys Asp Cys Ser Ile Asn Pro Lys Ser Pro Leu Leu Tyr
        195                 200                 205             
Val Thr Arg Pro Ser Glu Val Glu Lys Gly Val Leu Pro Gly Glu Asp
    210                 215                 220                 
Trp Thr Val Phe Gln Ser Asn His Ser Thr Tyr Glu Pro Val Leu Leu
225                 230                 235                 240 
Ala Lys Thr Arg Ser Ser Glu Ser Ile Pro His Leu Gly Ala Asp Ala
                245                 250                 255     
Gly Leu His Ala Ala Leu His Ala Thr Val Val Gln Asp Leu Gly Leu
            260                 265                 270         
His Asp Gly Ile Gln Arg Val Leu Phe Gly Asn Asn Leu Asn Phe Trp
        275                 280                 285             
Leu His Lys Leu Val Phe Val Asp Ala Val Ala Phe Leu Thr Gly Lys
    290                 295                 300                 
Arg Leu Ser Leu Pro Leu Asp Arg Tyr Ile Leu Val Asp Ile Asp Asp
305                 310                 315                 320 
Ile Phe Val Gly Lys Glu Gly Thr Arg Met Lys Val Glu Asp Val Lys
                325                 330                 335     
Ala Leu Phe Asp Thr Gln Asn Glu Leu Arg Ala His Ile Pro Asn Phe
            340                 345                 350         
Thr Phe Asn Leu Gly Tyr Ser Gly Lys Phe Phe Gln Thr Gly Thr Asn
        355                 360                 365             
Ala Glu Asp Ala Gly Asp Asp Leu Leu Leu Ser Tyr Val Lys Glu Phe
    370                 375                 380                 
Trp Trp Phe Pro His Met Trp Ser His Met Gln Pro His Leu Phe His
385                 390                 395                 400 
Asn Gln Ser Val Leu Ala Glu Gln Met Ala Leu Asn Lys Lys Phe Ala
                405                 410                 415     
Val Glu His Gly Ile Pro Thr Asp Met Gly Tyr Ala Val Ala Pro His
            420                 425                 430         
His Ser Gly Val Tyr Pro Val His Val Gln Leu Tyr Glu Ala Trp Lys
        435                 440                 445             
Gln Val Trp Ser Ile Arg Val Thr Ser Thr Glu Glu Tyr Pro His Leu
    450                 455                 460                 
Lys Pro Ala Arg Tyr Arg Arg Gly Phe Ile His Asn Gly Ile Met Val
465                 470                 475                 480 
Leu Pro Arg Gln Thr Cys Gly Leu Phe Thr His Thr Ile Phe Tyr Asn
                485                 490                 495     
Glu Tyr Pro Gly Gly Ser Ser Glu Leu Asp Lys Ile Ile Asn Gly Gly
            500                 505                 510         
Glu Leu Phe Leu Thr Val Leu Leu Asn Pro Val Ser Ala Pro Gln Pro
        515                 520                 525             
Met Ala Ala Gly Glu Lys Gly Leu Leu His Ser Leu Ser Ala Ala Asp
    530                 535                 540                 
Thr Gly Phe Leu Glu Pro Gly Lys Gly Gly Glu Ala
545                 550                 555     


<210> 9380
<211> 883
<212> PRT
<213> Homo sapiens

<400> 9380
Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp
 1               5                  10                  15      
Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu
            20                  25                  30          
Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met
        35                  40                  45              
Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn
    50                  55                  60                  
Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln
65                  70                  75                  80  
Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser
                85                  90                  95      
Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile
            100                 105                 110         
Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met
        115                 120                 125             
Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln
    130                 135                 140                 
Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr
145                 150                 155                 160 
Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr
                165                 170                 175     
Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr
            180                 185                 190         
Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile
        195                 200                 205             
Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile
    210                 215                 220                 
Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu
225                 230                 235                 240 
Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn
                245                 250                 255     
Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys
            260                 265                 270         
Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala
        275                 280                 285             
His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val
    290                 295                 300                 
Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu
305                 310                 315                 320 
Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val
                325                 330                 335     
Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln
            340                 345                 350         
Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg
        355                 360                 365             
Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg
    370                 375                 380                 
Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr
385                 390                 395                 400 
Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val
                405                 410                 415     
Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn
            420                 425                 430         
His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp
        435                 440                 445             
Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr
    450                 455                 460                 
Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile
465                 470                 475                 480 
Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala
                485                 490                 495     
Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe
            500                 505                 510         
Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro
        515                 520                 525             
Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr
    530                 535                 540                 
Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val
545                 550                 555                 560 
Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu
                565                 570                 575     
Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe
            580                 585                 590         
Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln
        595                 600                 605             
Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly
    610                 615                 620                 
Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn
625                 630                 635                 640 
Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser
                645                 650                 655     
Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp
            660                 665                 670         
Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe
        675                 680                 685             
Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val
    690                 695                 700                 
Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys
705                 710                 715                 720 
Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg
                725                 730                 735     
Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly
            740                 745                 750         
Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Asn Ala Val Asn
        755                 760                 765             
Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys
    770                 775                 780                 
Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp
785                 790                 795                 800 
Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val
                805                 810                 815     
Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu
            820                 825                 830         
Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val
        835                 840                 845             
Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln
    850                 855                 860                 
Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser
865                 870                 875                 880 
Val Lys Ile
            


<210> 9381
<211> 883
<212> PRT
<213> Homo sapiens

<400> 9381
Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp
 1               5                  10                  15      
Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu
            20                  25                  30          
Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met
        35                  40                  45              
Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn
    50                  55                  60                  
Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln
65                  70                  75                  80  
Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser
                85                  90                  95      
Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile
            100                 105                 110         
Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met
        115                 120                 125             
Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln
    130                 135                 140                 
Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr
145                 150                 155                 160 
Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr
                165                 170                 175     
Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr
            180                 185                 190         
Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile
        195                 200                 205             
Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile
    210                 215                 220                 
Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu
225                 230                 235                 240 
Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn
                245                 250                 255     
Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys
            260                 265                 270         
Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala
        275                 280                 285             
His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val
    290                 295                 300                 
Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu
305                 310                 315                 320 
Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val
                325                 330                 335     
Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln
            340                 345                 350         
Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg
        355                 360                 365             
Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg
    370                 375                 380                 
Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr
385                 390                 395                 400 
Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val
                405                 410                 415     
Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn
            420                 425                 430         
His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp
        435                 440                 445             
Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr
    450                 455                 460                 
Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile
465                 470                 475                 480 
Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala
                485                 490                 495     
Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe
            500                 505                 510         
Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro
        515                 520                 525             
Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr
    530                 535                 540                 
Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val
545                 550                 555                 560 
Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu
                565                 570                 575     
Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe
            580                 585                 590         
Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln
        595                 600                 605             
Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly
    610                 615                 620                 
Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn
625                 630                 635                 640 
Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser
                645                 650                 655     
Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp
            660                 665                 670         
Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe
        675                 680                 685             
Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val
    690                 695                 700                 
Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys
705                 710                 715                 720 
Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg
                725                 730                 735     
Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly
            740                 745                 750         
Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val Asn
        755                 760                 765             
Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys
    770                 775                 780                 
Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly
785                 790                 795                 800 
Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val
                805                 810                 815     
Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu
            820                 825                 830         
Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val
        835                 840                 845             
Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln
    850                 855                 860                 
Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser
865                 870                 875                 880 
Val Lys Ile
            


<210> 9382
<211> 436
<212> PRT
<213> Homo sapiens

<400> 9382
Met Thr Phe Gly Arg Ser Gly Ala Ala Ser Val Val Leu Asn Val Gly
 1               5                  10                  15      
Gly Ala Arg Tyr Ser Leu Ser Arg Glu Leu Leu Lys Asp Phe Pro Leu
            20                  25                  30          
Arg Arg Val Ser Arg Leu His Gly Cys Arg Ser Glu Arg Asp Val Leu
        35                  40                  45              
Glu Val Cys Asp Asp Tyr Asp Arg Glu Arg Asn Glu Tyr Phe Phe Asp
    50                  55                  60                  
Arg His Ser Glu Ala Phe Gly Phe Ile Leu Leu Tyr Val Arg Gly His
65                  70                  75                  80  
Gly Lys Leu Arg Phe Ala Pro Arg Met Cys Glu Leu Ser Phe Tyr Asn
                85                  90                  95      
Glu Met Ile Tyr Trp Gly Leu Glu Gly Ala His Leu Glu Tyr Cys Cys
            100                 105                 110         
Gln Arg Arg Leu Asp Asp Arg Met Ser Asp Thr Tyr Thr Phe Tyr Ser
        115                 120                 125             
Ala Asp Glu Pro Gly Val Leu Gly Arg Asp Glu Ala Arg Pro Gly Gly
    130                 135                 140                 
Ala Glu Ala Ala Pro Ser Arg Arg Trp Leu Glu Arg Met Arg Arg Thr
145                 150                 155                 160 
Phe Glu Glu Pro Thr Ser Ser Leu Ala Ala Gln Ile Leu Ala Ser Val
                165                 170                 175     
Ser Val Val Phe Val Ile Val Ser Met Val Val Leu Cys Ala Ser Thr
            180                 185                 190         
Leu Pro Asp Trp Arg Asn Ala Ala Ala Asp Asn Arg Ser Leu Asp Asp
        195                 200                 205             
Arg Ser Arg Tyr Ser Ala Gly Pro Gly Arg Glu Pro Ser Gly Ile Ile
    210                 215                 220                 
Glu Ala Ile Cys Ile Gly Trp Phe Thr Ala Glu Cys Ile Val Arg Phe
225                 230                 235                 240 
Ile Val Ser Lys Asn Lys Cys Glu Phe Val Lys Arg Pro Leu Asn Ile
                245                 250                 255     
Ile Asp Leu Leu Ala Ile Thr Pro Tyr Tyr Ile Ser Val Leu Met Thr
            260                 265                 270         
Val Phe Thr Gly Glu Asn Ser Gln Leu Gln Arg Ala Gly Val Thr Leu
        275                 280                 285             
Arg Val Leu Arg Met Met Arg Ile Phe Trp Val Ile Lys Leu Ala Arg
    290                 295                 300                 
His Phe Ile Gly Leu Gln Thr Leu Gly Leu Thr Leu Lys Arg Cys Tyr
305                 310                 315                 320 
Arg Glu Met Val Met Leu Leu Val Phe Ile Cys Val Ala Met Ala Ile
                325                 330                 335     
Phe Ser Ala Leu Ser Gln Leu Leu Glu His Gly Leu Asp Leu Glu Thr
            340                 345                 350         
Ser Asn Lys Asp Phe Thr Ser Ile Pro Ala Ala Cys Trp Trp Val Ile
        355                 360                 365             
Ile Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Ile Thr Val
    370                 375                 380                 
Pro Gly Arg Ile Leu Gly Gly Val Cys Val Val Ser Gly Ile Val Leu
385                 390                 395                 400 
Leu Ala Leu Pro Ile Thr Phe Ile Tyr His Ser Phe Val Gln Cys Tyr
                405                 410                 415     
His Glu Leu Lys Phe Arg Ser Ala Arg Tyr Ser Arg Ser Leu Ser Thr
            420                 425                 430         
Glu Phe Leu Asn
        435     


<210> 9383
<211> 425
<212> PRT
<213> Homo sapiens

<400> 9383
Met Thr Phe Gly Arg Ser Gly Ala Ala Ser Val Val Leu Asn Val Gly
 1               5                  10                  15      
Gly Ala Arg Tyr Ser Leu Ser Arg Glu Leu Leu Lys Asp Phe Pro Leu
            20                  25                  30          
Arg Arg Val Ser Arg Leu His Gly Cys Arg Ser Glu Arg Asp Val Leu
        35                  40                  45              
Glu Val Cys Asp Asp Tyr Asp Arg Glu Arg Asn Glu Tyr Phe Phe Asp
    50                  55                  60                  
Arg His Ser Glu Ala Phe Gly Phe Ile Leu Leu Tyr Val Arg Gly His
65                  70                  75                  80  
Gly Lys Leu Arg Phe Ala Pro Arg Met Cys Glu Leu Ser Phe Tyr Asn
                85                  90                  95      
Glu Met Ile Tyr Trp Gly Leu Glu Gly Ala His Leu Glu Tyr Cys Cys
            100                 105                 110         
Gln Arg Arg Leu Asp Asp Arg Met Ser Asp Thr Tyr Thr Phe Tyr Ser
        115                 120                 125             
Ala Asp Glu Pro Gly Val Leu Gly Arg Asp Glu Ala Arg Pro Gly Gly
    130                 135                 140                 
Ala Glu Ala Ala Pro Ser Arg Arg Trp Leu Glu Arg Met Arg Arg Thr
145                 150                 155                 160 
Phe Glu Glu Pro Thr Ser Ser Leu Ala Ala Gln Ile Leu Ala Ser Val
                165                 170                 175     
Ser Val Val Phe Val Ile Val Ser Met Val Val Leu Cys Ala Ser Thr
            180                 185                 190         
Leu Pro Asp Trp Arg Asn Ala Ala Ala Asp Asn Arg Ser Leu Asp Asp
        195                 200                 205             
Arg Ser Arg Ile Ile Glu Ala Ile Cys Ile Gly Trp Phe Thr Ala Glu
    210                 215                 220                 
Cys Ile Val Arg Phe Ile Val Ser Lys Asn Lys Cys Glu Phe Val Lys
225                 230                 235                 240 
Arg Pro Leu Asn Ile Ile Asp Leu Leu Ala Ile Thr Pro Tyr Tyr Ile
                245                 250                 255     
Ser Val Leu Met Thr Val Phe Thr Gly Glu Asn Ser Gln Leu Gln Arg
            260                 265                 270         
Ala Gly Val Thr Leu Arg Val Leu Arg Met Met Arg Ile Phe Trp Val
        275                 280                 285             
Ile Lys Leu Ala Arg His Phe Ile Gly Leu Gln Thr Leu Gly Leu Thr
    290                 295                 300                 
Leu Lys Arg Cys Tyr Arg Glu Met Val Met Leu Leu Val Phe Ile Cys
305                 310                 315                 320 
Val Ala Met Ala Ile Phe Ser Ala Leu Ser Gln Leu Leu Glu His Gly
                325                 330                 335     
Leu Asp Leu Glu Thr Ser Asn Lys Asp Phe Thr Ser Ile Pro Ala Ala
            340                 345                 350         
Cys Trp Trp Val Ile Ile Ser Met Thr Thr Val Gly Tyr Gly Asp Met
        355                 360                 365             
Tyr Pro Ile Thr Val Pro Gly Arg Ile Leu Gly Gly Val Cys Val Val
    370                 375                 380                 
Ser Gly Ile Val Leu Leu Ala Leu Pro Ile Thr Phe Ile Tyr His Ser
385                 390                 395                 400 
Phe Val Gln Cys Tyr His Glu Leu Lys Phe Arg Ser Ala Arg Tyr Ser
                405                 410                 415     
Arg Ser Leu Ser Thr Glu Phe Leu Asn
            420                 425 


<210> 9384
<211> 680
<212> PRT
<213> Homo sapiens

<400> 9384
Met Thr Leu Gln His Asn Ser Ala Leu Ser Pro Glu Leu Pro Leu Lys
 1               5                  10                  15      
Leu Gly Lys Ser Glu His Leu Val Leu Leu Thr Asn Ile Ser Ala Glu
            20                  25                  30          
Gly Thr Leu Asn Gln Ile Pro Leu Ser Leu Ser Cys Thr Thr Leu Cys
        35                  40                  45              
Cys Thr Ser Ser Pro Ala Phe Cys Leu Ser Arg Gly Gly Gly Gly Trp
    50                  55                  60                  
Ala Arg Arg Arg Met Gly Ala Ala Pro Ser Pro Thr Gln Ala Ser Ser
65                  70                  75                  80  
Arg Gly Gly Gly Pro Gly Pro Pro Ala Pro Thr Arg Ala Val Ser Ser
                85                  90                  95      
Ser Ser Arg Ala Arg Gly Gly Ala Leu Ser Ala Leu Gly Pro Ser Pro
            100                 105                 110         
Ala Arg Pro Leu Thr Thr Ser Pro Ala Pro Ala Pro Pro Pro Arg Ser
        115                 120                 125             
Arg Pro Ala Arg Gln Gln Pro Asp Pro Gln Cys Trp Glu Lys Arg Gly
    130                 135                 140                 
Gly Ala Gly Gly Asp Thr Lys Gly Gly Ala Ala Gly Pro Gly Pro Gly
145                 150                 155                 160 
Arg Leu Arg Gly Met Asp Ala Glu Tyr Pro Ala Phe Glu Pro Pro Leu
                165                 170                 175     
Cys Ser Glu Leu Lys His Leu Cys Arg Arg Leu Arg Glu Ala Tyr Arg
            180                 185                 190         
Glu Leu Lys Glu Asp Leu Thr Pro Phe Lys Asp Asp Arg Tyr Tyr Arg
        195                 200                 205             
Leu Ala Pro Met Arg Leu Tyr Thr Leu Ser Lys Arg His Phe Val Leu
    210                 215                 220                 
Val Phe Val Val Phe Phe Ile Cys Phe Gly Leu Thr Ile Phe Val Gly
225                 230                 235                 240 
Ile Arg Gly Pro Lys Val Ile Gln Thr Ser Ala Ala Asn Phe Ser Leu
                245                 250                 255     
Asn Asn Ser Lys Lys Leu Lys Pro Ile Gln Ile Leu Ser Asn Pro Leu
            260                 265                 270         
Ser Thr Tyr Asn Gln Gln Leu Trp Leu Thr Cys Val Val Glu Leu Asp
        275                 280                 285             
Gln Ser Lys Glu Thr Ser Ile Lys Thr Ser Phe Pro Met Thr Val Lys
    290                 295                 300                 
Val Asp Gly Val Ala Gln Asp Gly Thr Thr Met Tyr Ile His Asn Lys
305                 310                 315                 320 
Val His Asn Arg Thr Arg Thr Leu Thr Cys Ala Gly Lys Cys Ala Glu
                325                 330                 335     
Ile Ile Val Ala His Leu Gly Tyr Leu Asn Tyr Thr Gln Tyr Thr Val
            340                 345                 350         
Ile Val Gly Phe Glu His Leu Lys Leu Pro Ile Lys Gly Met Asn Phe
        355                 360                 365             
Thr Trp Lys Thr Tyr Asn Pro Ala Phe Ser Arg Leu Glu Ile Trp Phe
    370                 375                 380                 
Arg Phe Phe Phe Val Val Leu Thr Phe Ile Val Thr Cys Leu Phe Ala
385                 390                 395                 400 
His Ser Leu Arg Lys Phe Ser Met Arg Asp Trp Gly Ile Glu Gln Lys
                405                 410                 415     
Trp Met Ser Val Leu Leu Pro Leu Leu Leu Leu Tyr Asn Asp Pro Phe
            420                 425                 430         
Phe Pro Leu Ser Phe Leu Val Asn Ser Trp Leu Pro Gly Met Leu Asp
        435                 440                 445             
Asp Leu Phe Gln Ser Met Phe Leu Cys Ala Leu Leu Leu Phe Trp Leu
    450                 455                 460                 
Cys Val Tyr His Gly Ile Arg Val Gln Gly Glu Arg Lys Cys Leu Thr
465                 470                 475                 480 
Phe Tyr Leu Pro Lys Phe Phe Ile Val Gly Leu Leu Trp Leu Ala Ser
                485                 490                 495     
Val Thr Leu Gly Ile Trp Gln Thr Val Asn Glu Leu His Asp Pro Met
            500                 505                 510         
Tyr Gln Tyr Arg Val Asp Thr Gly Asn Phe Gln Gly Met Lys Val Phe
        515                 520                 525             
Phe Met Val Val Ala Ala Val Tyr Ile Leu Tyr Leu Leu Phe Leu Ile
    530                 535                 540                 
Val Arg Ala Cys Ser Glu Leu Arg His Met Pro Tyr Val Asp Leu Arg
545                 550                 555                 560 
Leu Lys Phe Leu Thr Ala Leu Thr Phe Val Val Leu Val Ile Ser Ile
                565                 570                 575     
Ala Ile Leu Tyr Leu Arg Phe Gly Ala Gln Val Leu Gln Asp Asn Phe
            580                 585                 590         
Val Ala Glu Leu Ser Thr His Tyr Gln Asn Ser Ala Glu Phe Leu Ser
        595                 600                 605             
Phe Tyr Gly Leu Leu Asn Phe Tyr Leu Tyr Thr Leu Ala Phe Val Tyr
    610                 615                 620                 
Ser Pro Ser Lys Asn Ala Leu Tyr Glu Ser Gln Leu Lys Asp Asn Pro
625                 630                 635                 640 
Ala Phe Ser Met Leu Asn Asp Ser Asp Asp Asp Val Ile Tyr Gly Ser
                645                 650                 655     
Asp Tyr Glu Glu Met Pro Leu Gln Asn Gly Gln Ala Ile Arg Ala Lys
            660                 665                 670         
Tyr Lys Glu Glu Ser Asp Ser Asp
        675                 680 


<210> 9385
<211> 523
<212> PRT
<213> Homo sapiens

<400> 9385
Leu Pro Ser Pro Gly Pro Ala Gln Arg Ala Ser Ser Pro Ile Pro Ser
 1               5                  10                  15      
Ala Gly Arg Arg Glu Gly Ala Gln Ala Ala Thr Gln Arg Val Glu Arg
            20                  25                  30          
Arg Asp Arg Asp Pro Gly Gly Cys Ala Ala Trp Thr Pro Ser Thr Leu
        35                  40                  45              
Pro Leu Ser Pro Arg Ser Ala Ala Ser Ser Ser Thr Cys Ala Gly Gly
    50                  55                  60                  
Cys Gly Lys Arg Thr Ala Ser Ser Arg Arg Thr Ser Arg Pro Ser Arg
65                  70                  75                  80  
Met Thr Ala Thr Thr Gly Pro Lys Val Ile Gln Thr Ser Ala Ala Asn
                85                  90                  95      
Phe Ser Leu Asn Asn Ser Lys Lys Leu Lys Pro Ile Gln Ile Leu Ser
            100                 105                 110         
Asn Pro Leu Ser Thr Tyr Asn Gln Gln Leu Trp Leu Thr Cys Val Val
        115                 120                 125             
Glu Leu Asp Gln Ser Lys Glu Thr Ser Ile Lys Thr Ser Phe Pro Met
    130                 135                 140                 
Thr Val Lys Val Asp Gly Val Ala Gln Asp Gly Thr Thr Met Tyr Ile
145                 150                 155                 160 
His Asn Lys Val His Asn Arg Thr Arg Thr Leu Thr Cys Ala Gly Lys
                165                 170                 175     
Cys Ala Glu Ile Ile Val Ala His Leu Gly Tyr Leu Asn Tyr Thr Gln
            180                 185                 190         
Tyr Thr Val Ile Val Gly Phe Glu His Leu Lys Leu Pro Ile Lys Gly
        195                 200                 205             
Met Asn Phe Thr Trp Lys Thr Tyr Asn Pro Ala Phe Ser Arg Leu Glu
    210                 215                 220                 
Ile Trp Phe Arg Phe Phe Phe Val Val Leu Thr Phe Ile Val Thr Cys
225                 230                 235                 240 
Leu Phe Ala His Ser Leu Arg Lys Phe Ser Met Arg Asp Trp Gly Ile
                245                 250                 255     
Glu Gln Lys Trp Met Ser Val Leu Leu Pro Leu Leu Leu Leu Tyr Asn
            260                 265                 270         
Asp Pro Phe Phe Pro Leu Ser Phe Leu Val Asn Ser Trp Leu Pro Gly
        275                 280                 285             
Met Leu Asp Asp Leu Phe Gln Ser Met Phe Leu Cys Ala Leu Leu Leu
    290                 295                 300                 
Phe Trp Leu Cys Val Tyr His Gly Ile Arg Val Gln Gly Glu Arg Lys
305                 310                 315                 320 
Cys Leu Thr Phe Tyr Leu Pro Lys Phe Phe Ile Val Gly Leu Leu Trp
                325                 330                 335     
Leu Ala Ser Val Thr Leu Gly Ile Trp Gln Thr Val Asn Glu Leu His
            340                 345                 350         
Asp Pro Met Tyr Gln Tyr Arg Val Asp Thr Gly Asn Phe Gln Gly Met
        355                 360                 365             
Lys Val Phe Phe Met Val Val Ala Ala Val Tyr Ile Leu Tyr Leu Leu
    370                 375                 380                 
Phe Leu Ile Val Arg Ala Cys Ser Glu Leu Arg His Met Pro Tyr Val
385                 390                 395                 400 
Asp Leu Arg Leu Lys Phe Leu Thr Ala Leu Thr Phe Val Val Leu Val
                405                 410                 415     
Ile Ser Ile Ala Ile Leu Tyr Leu Arg Phe Gly Ala Gln Val Leu Gln
            420                 425                 430         
Asp Asn Phe Val Ala Glu Leu Ser Thr His Tyr Gln Asn Ser Ala Glu
        435                 440                 445             
Phe Leu Ser Phe Tyr Gly Leu Leu Asn Phe Tyr Leu Tyr Thr Leu Ala
    450                 455                 460                 
Phe Val Tyr Ser Pro Ser Lys Asn Ala Leu Tyr Glu Ser Gln Leu Lys
465                 470                 475                 480 
Asp Asn Pro Ala Phe Ser Met Leu Asn Asp Ser Asp Asp Asp Val Ile
                485                 490                 495     
Tyr Gly Ser His Tyr Glu Glu Met Pro Leu Gln Asn Gly Gln Ala Ile
            500                 505                 510         
Arg Ala Lys Tyr Lys Glu Glu Ser Asp Ser Asp
        515                 520             


<210> 9386
<211> 997
<212> PRT
<213> Homo sapiens

<400> 9386
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe
 1               5                  10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe
            500                 505                 510         
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg
        515                 520                 525             
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile
    530                 535                 540                 
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys
545                 550                 555                 560 
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His
                565                 570                 575     
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe
            580                 585                 590         
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser
        595                 600                 605             
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr
    610                 615                 620                 
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile
625                 630                 635                 640 
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu
                645                 650                 655     
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala
            660                 665                 670         
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu
        675                 680                 685             
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val
    690                 695                 700                 
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly
705                 710                 715                 720 
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp
                725                 730                 735     
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile
            740                 745                 750         
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val
        755                 760                 765             
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu
    770                 775                 780                 
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly
785                 790                 795                 800 
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met
                805                 810                 815     
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu
            820                 825                 830         
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val
        835                 840                 845             
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val
    850                 855                 860                 
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro
865                 870                 875                 880 
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met
                885                 890                 895     
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu
            900                 905                 910         
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu
        915                 920                 925             
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe
    930                 935                 940                 
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro
945                 950                 955                 960 
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val
                965                 970                 975     
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu
            980                 985                 990         
Pro Ala Ile Leu Glu
        995         


<210> 9387
<211> 1054
<212> PRT
<213> Homo sapiens

<400> 9387
Gly Cys Ser Ser Gly Thr Gly Val Arg Ala Leu Trp Arg Glu Glu Lys
 1               5                  10                  15      
Pro Gly Gly Gly Arg Arg Val Lys Arg Arg Asn Pro Gly Arg Gln Ala
            20                  25                  30          
Val Gly His Thr Glu Glu Asp Pro Pro Arg Val Gly Thr Pro Trp Lys
        35                  40                  45              
Glu His Thr Gly Pro Gly Pro Gln Glu Gly Ser Thr Met Glu Ala Ala
    50                  55                  60                  
His Ala Lys Thr Thr Glu Glu Cys Leu Ala Tyr Phe Gly Val Gly Glu
65                  70                  75                  80  
Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn Leu Glu Lys Tyr
                85                  90                  95      
Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr Leu Trp Glu Leu
            100                 105                 110         
Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile Leu Leu Leu Ala
        115                 120                 125             
Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu Gly Glu Glu Thr
    130                 135                 140                 
Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu Ile Leu Ile Ala
145                 150                 155                 160 
Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala Glu Asn Ala Ile
                165                 170                 175     
Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys Val Tyr Arg Ala
            180                 185                 190         
Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp Ile Val Pro Gly
        195                 200                 205             
Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro Ala Asp Ile Arg
    210                 215                 220                 
Ile Leu Ala Ile Lys Ser Thr Thr Leu Arg Val Asp Gln Ser Ile Leu
225                 230                 235                 240 
Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Glu Pro Val Pro Asp
                245                 250                 255     
Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu Phe Ser Gly Thr
            260                 265                 270         
Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala Thr Thr Gly Val
        275                 280                 285             
Gly Thr Glu Ile Gly Arg Ile Arg Asp Gln Met Ala Ala Thr Glu Gln
    290                 295                 300                 
Asp Lys Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe Gly Glu Gln Leu
305                 310                 315                 320 
Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp Leu Ile Asn Ile
                325                 330                 335     
Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp Phe Arg Gly Ala
            340                 345                 350         
Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val Ala Ala Ile Pro
        355                 360                 365             
Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala Leu Gly Thr Arg
    370                 375                 380                 
Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu Pro Ser Val Glu
385                 390                 395                 400 
Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys Thr Gly Thr Leu
                405                 410                 415     
Thr Thr Asn Gln Met Ser Val Cys Lys Met Phe Ile Ile Asp Lys Val
            420                 425                 430         
Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile Thr Gly Ser Thr
        435                 440                 445             
Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys Pro Val Arg Pro
    450                 455                 460                 
Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile Cys Ala Leu Cys
465                 470                 475                 480 
Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly Val Tyr Glu Lys
                485                 490                 495     
Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Thr Leu Val Glu Lys Met
            500                 505                 510         
Asn Val Phe Asn Thr Asp Val Arg Ser Leu Ser Lys Val Glu Arg Ala
        515                 520                 525             
Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys Lys Glu Phe Thr
    530                 535                 540                 
Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val Tyr Cys Ser Pro
545                 550                 555                 560 
Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met Phe Val Lys Gly
                565                 570                 575     
Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val Arg Val Gly Thr
            580                 585                 590         
Thr Arg Val Pro Pro Thr Gly Pro Val Lys Glu Lys Ile Met Ala Val
        595                 600                 605             
Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg Cys Leu Ala Leu
    610                 615                 620                 
Ala Thr Arg Asp Thr Pro Pro Lys Arg Glu Glu Met Val Leu Asp Asp
625                 630                 635                 640 
Ser Ala Arg Phe Leu Glu Tyr Glu Thr Asp Leu Thr Phe Val Gly Val
                645                 650                 655     
Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Thr Gly Ser Ile Gln
            660                 665                 670         
Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile Thr Gly Asp His
        675                 680                 685             
Lys Gly Thr Ala Ile Ala Ile Cys Arg Arg Ile Gly Ile Phe Gly Glu
    690                 695                 700                 
Asn Glu Glu Val Ala Asp Arg Ala Tyr Thr Gly Arg Glu Phe Asp Asp
705                 710                 715                 720 
Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg Ala Cys Cys Phe
                725                 730                 735     
Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu Tyr Leu Gln
            740                 745                 750         
Ser Tyr Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val Asn Asp Ala
        755                 760                 765             
Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly Ser Gly Thr
    770                 775                 780                 
Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp Asp Asn Phe
785                 790                 795                 800 
Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile Tyr Asn Asn
                805                 810                 815     
Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val Gly Glu Val
            820                 825                 830         
Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro Glu Ala Leu Ile
        835                 840                 845             
Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly Leu Pro Ala
    850                 855                 860                 
Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met Asp Arg Pro
865                 870                 875                 880 
Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu Phe Phe Arg
                885                 890                 895     
Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Thr Val Gly Ala Ala
            900                 905                 910         
Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His Val Asn Tyr Ser
        915                 920                 925             
Gln Leu Thr His Phe Met Gln Cys Thr Glu Asp Asn Thr His Phe Glu
    930                 935                 940                 
Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro Met Thr Met Ala
945                 950                 955                 960 
Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu Asn Ser Leu
                965                 970                 975     
Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Val Asn Ile Trp
            980                 985                 990         
Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe Leu Ile Leu
        995                 1000                1005            
Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg Ala Leu Asp Leu
    1010                1015                1020                
Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val Ile Gly Leu
1025                1030                1035                1040
Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu Gly
                1045                1050                


<210> 9388
<211> 1043
<212> PRT
<213> Homo sapiens

<400> 9388
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe
 1               5                  10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe
            500                 505                 510         
Val Lys Ala Arg Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile
        515                 520                 525             
Arg Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys
    530                 535                 540                 
Ile Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg
545                 550                 555                 560 
Cys Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met
                565                 570                 575     
His Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr
            580                 585                 590         
Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala
        595                 600                 605             
Ser Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile
    610                 615                 620                 
Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly
625                 630                 635                 640 
Ile Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg
                645                 650                 655     
Glu Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn
            660                 665                 670         
Ala Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val
        675                 680                 685             
Glu Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly
    690                 695                 700                 
Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met
705                 710                 715                 720 
Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala
                725                 730                 735     
Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala
            740                 745                 750         
Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn
        755                 760                 765             
Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro
    770                 775                 780                 
Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp
785                 790                 795                 800 
Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile
                805                 810                 815     
Met Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp
            820                 825                 830         
Leu Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr
        835                 840                 845             
Val Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg
    850                 855                 860                 
Val Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn
865                 870                 875                 880 
Pro Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro
                885                 890                 895     
Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala
            900                 905                 910         
Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp
        915                 920                 925             
Glu Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His
    930                 935                 940                 
Phe Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr
945                 950                 955                 960 
Pro Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro
                965                 970                 975     
Val Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu
            980                 985                 990         
Glu Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys Ser Cys Ser Phe
        995                 1000                1005            
Ser Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met
    1010                1015                1020                
Pro Leu Val Ile Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met
1025                1030                1035                1040
Phe Trp Ser
            


<210> 9389
<211> 1001
<212> PRT
<213> Homo sapiens

<400> 9389
Met Glu Ala Ala His Ala Lys Thr Thr Glu Glu Cys Leu Ala Tyr Phe
 1               5                  10                  15      
Gly Val Ser Glu Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn
            20                  25                  30          
Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr
        35                  40                  45              
Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu
                85                  90                  95      
Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys
        115                 120                 125             
Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro
145                 150                 155                 160 
Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Thr Thr Leu Arg Val Asp
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Glu
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala
    210                 215                 220                 
Thr Thr Gly Val Gly Thr Glu Ile Gly Lys Ile Arg Asp Gln Met Ala
225                 230                 235                 240 
Ala Thr Glu Gln Asp Lys Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp
            260                 265                 270         
Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp
        275                 280                 285             
Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Lys Met Phe Ile
        355                 360                 365             
Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys
385                 390                 395                 400 
Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Thr Leu
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asn Thr Asp Val Arg Ser Leu Ser Lys
    450                 455                 460                 
Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val
                485                 490                 495     
Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met
            500                 505                 510         
Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val
        515                 520                 525             
Arg Val Gly Thr Thr Arg Val Pro Leu Thr Gly Pro Val Lys Glu Lys
    530                 535                 540                 
Ile Met Ala Val Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg
545                 550                 555                 560 
Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Lys Arg Glu Glu Met
                565                 570                 575     
Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Thr Asp Leu Thr
            580                 585                 590         
Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Thr
        595                 600                 605             
Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile
    610                 615                 620                 
Thr Gly Asp Asn Lys Gly Thr Ala Ile Ala Ile Cys Arg Arg Ile Gly
625                 630                 635                 640 
Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Thr Gly Arg
                645                 650                 655     
Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg
            660                 665                 670         
Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val
        675                 680                 685             
Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Thr Ala Met Thr Gly Asp Gly
    690                 695                 700                 
Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met
705                 710                 715                 720 
Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala
                725                 730                 735     
Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala
            740                 745                 750         
Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn
        755                 760                 765             
Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro
    770                 775                 780                 
Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp
785                 790                 795                 800 
Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile
                805                 810                 815     
Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp
            820                 825                 830         
Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Thr
        835                 840                 845             
Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His
    850                 855                 860                 
Val Asn Tyr Ser Gln Leu Thr His Phe Met Gln Cys Thr Glu Asp Asn
865                 870                 875                 880 
Thr His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro
                885                 890                 895     
Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala
            900                 905                 910         
Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp
        915                 920                 925             
Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His
    930                 935                 940                 
Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg
945                 950                 955                 960 
Ala Leu Asp Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro
                965                 970                 975     
Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu
            980                 985                 990         
Glu Asp Pro Glu Asp Glu Arg Arg Lys
        995                 1000    


<210> 9390
<211> 438
<212> PRT
<213> Homo sapiens

<400> 9390
Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu
 1               5                  10                  15      
Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala
            20                  25                  30          
Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu
        35                  40                  45              
Gln Tyr Cys His Thr Ile Met Thr Leu Thr Asn Leu Ser Gly Pro Tyr
    50                  55                  60                  
Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly Thr Cys Trp Pro Arg
65                  70                  75                  80  
Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys Pro Glu Tyr Phe Asn
                85                  90                  95      
Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr Arg Glu Cys Leu Glu
            100                 105                 110         
Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser Gln Cys Glu Pro Ile
        115                 120                 125             
Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His Tyr Arg Ile Ala Leu
    130                 135                 140                 
Val Val Asn Tyr Leu Gly His Cys Val Ser Val Ala Ala Leu Val Ala
145                 150                 155                 160 
Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile Arg Cys Leu Arg Asn
                165                 170                 175     
Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile Leu Arg Asn Val Met
            180                 185                 190         
Trp Phe Leu Leu Gln Leu Val Asp His Glu Val His Glu Ser Asn Glu
        195                 200                 205             
Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn Tyr Phe Val Val Thr
    210                 215                 220                 
Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr Leu His Thr Ala Ile
225                 230                 235                 240 
Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys Cys Leu Phe Leu Phe
                245                 250                 255     
Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val Ala Trp Ala Ile Gly
            260                 265                 270         
Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe Gly Lys Glu Pro Gly
        275                 280                 285             
Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile Ile Leu Val Leu Leu
    290                 295                 300                 
Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg Ile Leu Met Thr Lys
305                 310                 315                 320 
Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln Tyr Arg Lys Ala Val
                325                 330                 335     
Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly Ile Thr Tyr Met Leu
            340                 345                 350         
Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser Gln Ile Met Phe Ile
        355                 360                 365             
Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly Phe Phe Val Ser Val
    370                 375                 380                 
Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser Ala Val Arg Lys Arg
385                 390                 395                 400 
Trp His Arg Trp Gln Asp His His Ser Leu Arg Val Pro Met Ala Arg
                405                 410                 415     
Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile Ser Phe His Ser Ile
            420                 425                 430         
Lys Gln Thr Ala Ala Val
        435             


<210> 9391
<211> 290
<212> PRT
<213> Homo sapiens

<400> 9391
Met Met Pro Gln Glu Gln Tyr Thr His His Arg Ser Thr Met Pro Gly
 1               5                  10                  15      
Ser Val Gly Pro Gln Val Tyr Lys Val Gly Ile Tyr Gly Trp Arg Lys
            20                  25                  30          
Arg Cys Leu Tyr Phe Phe Val Leu Leu Leu Met Ile Leu Ile Leu Val
        35                  40                  45              
Asn Leu Ala Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Ile
    50                  55                  60                  
Asp Gly Met Gly Asn Leu Arg Ile Thr Glu Lys Gly Leu Lys Leu Glu
65                  70                  75                  80  
Gly Asp Ser Glu Phe Leu Gln Pro Leu Tyr Ala Lys Glu Ile Gln Ser
                85                  90                  95      
Gln Pro Gly Asn Ala Leu Tyr Phe Lys Ser Ala Arg Asn Val Thr Val
            100                 105                 110         
Asn Ile Leu Asn Asp Gln Thr Lys Val Leu Thr Gln Leu Ile Thr Gly
        115                 120                 125             
Pro Lys Ala Val Glu Ala Tyr Gly Lys Lys Phe Glu Val Lys Thr Val
    130                 135                 140                 
Ser Gly Lys Leu Leu Phe Ser Ala Asp Asn Asn Glu Val Val Val Gly
145                 150                 155                 160 
Ala Glu Arg Leu Arg Val Leu Gly Ala Glu Gly Thr Val Phe Pro Lys
                165                 170                 175     
Ser Ile Glu Thr Pro Asn Val Arg Ala Asp Pro Phe Lys Glu Leu Arg
            180                 185                 190         
Leu Glu Ser Pro Thr Arg Ser Leu Val Met Glu Ala Pro Lys Gly Val
        195                 200                 205             
Glu Ile Asn Ala Glu Ala Gly Asn Met Glu Ala Thr Cys Arg Thr Glu
    210                 215                 220                 
Leu Arg Leu Glu Ser Lys Asp Gly Glu Ile Lys Leu Asp Ala Ala Lys
225                 230                 235                 240 
Ile Arg Leu Pro Arg Leu Pro His Gly Ser Tyr Thr Pro Thr Gly Thr
                245                 250                 255     
Arg Gln Lys Val Phe Glu Ile Cys Val Cys Ala Asn Gly Arg Leu Phe
            260                 265                 270         
Leu Ser Gln Ala Gly Ala Gly Ser Thr Cys Gln Ile Asn Thr Ser Val
        275                 280                 285             
Cys Leu
    290 


<210> 9392
<211> 334
<212> PRT
<213> Homo sapiens

<400> 9392
Leu Gly Gln Leu Leu Ser Ala Gly Trp Ala Cys Thr His Ser Ala Gly
 1               5                  10                  15      
Arg Val Ala Thr Ser Phe Arg Ala Ala Gln His Ala Leu Gly Ser Arg
            20                  25                  30          
Ala Val Phe Ile Gly Arg Phe Val Lys Arg Thr Arg Glu Met Pro Gln
        35                  40                  45              
Glu Gln Tyr Thr His His Arg Ser Thr Met Pro Gly Ser Val Gly Pro
    50                  55                  60                  
Gln Val Tyr Lys Val Gly Ile Tyr Gly Trp Arg Lys Arg Cys Leu Tyr
65                  70                  75                  80  
Phe Phe Val Leu Leu Leu Met Ile Leu Ile Leu Val Asn Leu Ala Met
                85                  90                  95      
Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Ile Asp Gly Met Gly
            100                 105                 110         
Asn Leu Arg Ile Thr Glu Lys Gly Leu Lys Leu Glu Gly Asp Ser Glu
        115                 120                 125             
Phe Leu Gln Pro Leu Tyr Ala Lys Glu Ile Gln Ser Arg Pro Gly Asn
    130                 135                 140                 
Ala Leu Tyr Phe Lys Ser Ala Arg Asn Val Thr Val Asn Ile Leu Asn
145                 150                 155                 160 
Asp Gln Thr Lys Val Leu Thr Gln Leu Ile Thr Gly Pro Lys Ala Val
                165                 170                 175     
Glu Ala Tyr Gly Lys Lys Phe Glu Val Lys Thr Val Ser Gly Lys Leu
            180                 185                 190         
Leu Phe Ser Ala Asp Asn Asn Glu Val Val Val Gly Ala Glu Arg Leu
        195                 200                 205             
Arg Val Leu Gly Ala Glu Gly Thr Val Phe Pro Lys Ser Ile Glu Thr
    210                 215                 220                 
Pro Asn Val Arg Ala Asp Pro Phe Lys Glu Leu Arg Leu Glu Ser Pro
225                 230                 235                 240 
Thr Arg Ser Leu Val Met Glu Ala Pro Lys Gly Val Glu Ile Asn Ala
                245                 250                 255     
Glu Ala Gly Asn Met Glu Ala Thr Cys Arg Thr Glu Leu Arg Leu Glu
            260                 265                 270         
Ser Lys Asp Gly Glu Ile Lys Leu Asp Ala Ala Lys Ile Arg Leu Pro
        275                 280                 285             
Arg Leu Pro His Gly Ser Tyr Thr Pro Thr Gly Thr Arg Gln Lys Val
    290                 295                 300                 
Phe Glu Ile Cys Val Cys Ala Asn Gly Arg Leu Phe Leu Ser Gln Ala
305                 310                 315                 320 
Gly Ala Gly Ser Thr Cys Gln Ile Asn Thr Ser Val Cys Leu
                325                 330                 


<210> 9393
<211> 256
<212> PRT
<213> Homo sapiens

<400> 9393
Met Met Pro Gln Glu Gln Tyr Thr His His Arg Ser Thr Met Pro Gly
 1               5                  10                  15      
Ser Val Gly Pro Gln Val Tyr Lys Val Gly Ile Tyr Gly Trp Arg Lys
            20                  25                  30          
Arg Cys Leu Tyr Phe Phe Val Leu Leu Leu Met Ile Leu Ile Leu Val
        35                  40                  45              
Asn Leu Ala Met Thr Ile Trp Ile Leu Lys Val Met Asn Phe Thr Ile
    50                  55                  60                  
Asp Gly Met Gly Asn Leu Arg Ile Thr Glu Lys Gly Leu Lys Leu Glu
65                  70                  75                  80  
Gly Asp Ser Glu Phe Leu Gln Pro Leu Tyr Ala Lys Glu Ile Gln Ser
                85                  90                  95      
Arg Pro Gly Asn Ala Leu Tyr Phe Lys Ser Ala Arg Asn Val Thr Val
            100                 105                 110         
Asn Ile Leu Asn Asp Gln Thr Lys Val Leu Thr Gln Leu Ile Thr Gly
        115                 120                 125             
Pro Lys Ala Val Glu Ala Tyr Gly Lys Lys Phe Glu Val Lys Thr Val
    130                 135                 140                 
Ser Gly Lys Leu Leu Phe Ser Ala Asp Asn Asn Glu Val Val Val Gly
145                 150                 155                 160 
Ala Glu Arg Leu Arg Val Leu Gly Ala Glu Gly Thr Val Phe Pro Lys
                165                 170                 175     
Ser Ile Glu Thr Pro Asn Val Arg Ala Asp Pro Phe Lys Glu Leu Arg
            180                 185                 190         
Leu Glu Ser Pro Thr Arg Ser Leu Val Met Glu Ala Pro Lys Gly Val
        195                 200                 205             
Glu Ile Asn Ala Glu Ala Gly Asn Met Glu Ala Thr Cys Arg Thr Glu
    210                 215                 220                 
Leu Arg Leu Glu Ser Lys Asp Gly Glu Val Arg Asp Glu Lys Asp Arg
225                 230                 235                 240 
Ser Ser Lys Ser Tyr Ser Phe Asn Arg Pro Thr Leu Pro Ile Thr Gly
                245                 250                 255     


<210> 9394
<211> 2253
<212> PRT
<213> Homo sapiens

<400> 9394
Met Arg Pro Gly Pro Ala Leu Leu Leu Leu Gly Val Gly Leu Ser Leu
 1               5                  10                  15      
Ser Val Gly Arg Leu Pro Leu Pro Pro Val Pro Arg Gly Ala Gln Ala
            20                  25                  30          
Ala Val Ser Gly Ala Pro Gly Gly Leu Leu Arg Gly Ala Pro Gly Leu
        35                  40                  45              
Gly Val Arg Gly Gly Arg Ala Leu Leu Ser Leu Arg Pro Ser Ala Val
    50                  55                  60                  
Arg Ala Gly Gly Ala Val Leu Ser Gly Arg Gly Ser Leu Cys Phe Pro
65                  70                  75                  80  
His Gly Gly Thr Gly Arg Arg Trp Tyr Cys Leu Asp Leu Arg Val Leu
                85                  90                  95      
Leu Ser Ala Gln Arg Leu Pro Trp Pro Ala Ala Pro Ala Leu Ala Leu
            100                 105                 110         
Val Asp Leu Gln Leu Ser Ala Arg Gly Gly Arg Leu Ser Leu Thr Trp
        115                 120                 125             
Ser Val Arg Leu Pro Arg Ser Pro Gly Arg Leu Ala Trp Ala Phe Arg
    130                 135                 140                 
Leu Arg Leu Leu Gly Pro Gly Ala Ala Arg Pro Ala Ser Pro Ala Ala
145                 150                 155                 160 
Arg Val Ser Pro Arg Ser Ala Ala Pro Gly Pro Arg Pro Gln Gln Gly
                165                 170                 175     
Phe Val Ala Arg Thr Glu Cys Pro Thr Asp Gly Pro Ala Arg Val Met
            180                 185                 190         
Leu Gln Ala Val Asn Ser Ser Ser His Arg Ala Val Glu Ser Ser Val
        195                 200                 205             
Ser Cys Gln Ile Asn Ala Cys Val Ile Gln Arg Val Arg Ile Asn Thr
    210                 215                 220                 
Asp Gln Lys Gly Ala Pro Val Arg Leu Ser Met Gln Ala Glu Ala Thr
225                 230                 235                 240 
Ile Asn Ala Ser Val Gln Leu Asp Cys Pro Ala Ala Arg Ala Ile Ala
                245                 250                 255     
Gln Tyr Trp Gln Val Phe Ser Val Pro Ala Val Gly Gln Ala Pro Asp
            260                 265                 270         
Trp Thr Gln Pro Leu Asp Leu Pro Gln Leu Glu Ile Arg Asn Ser Pro
        275                 280                 285             
Leu Phe Ile His Ile Pro Asn Asn Ser Leu Gln Trp Gly Val Tyr Val
    290                 295                 300                 
Phe Asn Phe Thr Val Ser Ile Thr Thr Gly Asn Pro Lys Met Pro Glu
305                 310                 315                 320 
Val Lys Asp Ser Asp Ala Val Tyr Val Trp Ile Val Arg Ser Ser Leu
                325                 330                 335     
Gln Ala Val Met Leu Gly Asp Ala Asn Ile Thr Ala Asn Phe Thr Glu
            340                 345                 350         
Gln Leu Ile Leu Asp Gly Ser Thr Ser Ser Asp Pro Asp Ala Asp Ser
        355                 360                 365             
Pro Leu Gln Gly Leu Gln Phe Phe Trp Tyr Cys Thr Thr Asp Pro Arg
    370                 375                 380                 
Asn Tyr Gly Gly Asp Arg Ile Ile Leu Gly Ser Lys Glu Val Cys His
385                 390                 395                 400 
Pro Glu Gln Ala Asn Leu Lys Trp Pro Trp Ala Ser Gly Pro Val Leu
                405                 410                 415     
Thr Leu Leu Pro Glu Thr Leu Lys Gly Asp His Val Tyr Phe Phe Arg
            420                 425                 430         
Met Val Ile Arg Lys Asp Ser Arg Thr Ala Phe Ser Asp Lys Arg Val
        435                 440                 445             
His Val Leu Gln Gly Pro Lys Ala Ile Ala His Ile Thr Cys Ile Glu
    450                 455                 460                 
Asn Cys Glu Arg Asn Phe Ile Val Ser Asp Arg Phe Ser Leu Phe Leu
465                 470                 475                 480 
Asn Cys Thr Asn Cys Ala Ser Arg Asp Phe Tyr Lys Trp Ser Ile Leu
                485                 490                 495     
Ser Ser Ser Gly Gly Glu Met Leu Phe Asp Trp Met Gly Glu Thr Val
            500                 505                 510         
Thr Gly Arg Asn Gly Ala Tyr Leu Ser Ile Lys Ala Phe Ala Phe Arg
        515                 520                 525             
His Phe Leu Glu Ala Glu Phe Ser Ile Ser Leu Tyr Leu Ala Cys Trp
    530                 535                 540                 
Ser Gly Val Thr Ser Val Phe Arg His Ser Phe Ile Ile Asn His Gly
545                 550                 555                 560 
Pro Gln Ile Gly Glu Cys Lys Ile Asn Pro Ala Lys Gly Ile Ala Leu
                565                 570                 575     
Ile Thr Lys Phe Val Val Gln Cys Ser Asn Phe Arg Asp Lys His Val
            580                 585                 590         
Pro Leu Thr Tyr Lys Ile Ile Val Ser Asp Leu His Ser Val Gly Glu
        595                 600                 605             
Ile Ser Ser Val Lys Glu Asn Thr Leu Gly Thr Ile Leu Tyr Leu Gly
    610                 615                 620                 
Pro Gln Ser Thr Val Pro Pro Ser Phe Leu Pro Val Gly Met Leu Ala
625                 630                 635                 640 
Ser Gln Tyr Gly Leu Lys Ile Tyr Ala Gln Val Tyr Asp Ser Leu Gly
                645                 650                 655     
Ala Phe Ser Gln Val Thr Leu His Ala Thr Ala Gln Ala Pro Thr Asp
            660                 665                 670         
Lys Asn Ser Ser Lys Thr Val Leu Asn Gln Leu Leu Ser Phe Thr Val
        675                 680                 685             
Gly Pro Ser Ser Leu Leu Ser Thr Leu Ile Gln Lys Lys Asp Phe Leu
    690                 695                 700                 
Pro Ala Gly Tyr Leu Leu Tyr Ile Val Ala Ser Val Leu Asn Asn Met
705                 710                 715                 720 
Lys Thr Glu Leu Pro Leu Arg Asp Asp Arg Val Asn Leu Arg Lys His
                725                 730                 735     
Leu Ile Asp Gln Ser Phe Leu Leu Pro Val Ser Thr Leu Val Glu Ile
            740                 745                 750         
Gly Gln Val Val Met Thr Ile Thr Lys Leu Thr Gln Lys Pro Ser Glu
        755                 760                 765             
Phe Thr Trp Asp Ala Gln Lys Arg Ala Thr Met Arg Val Trp Gln Ala
    770                 775                 780                 
Asn Gln Ala Leu Gln Glu Tyr Gln Gln Lys Asp Lys Arg Phe Arg Ser
785                 790                 795                 800 
Glu Gln Ile Glu Ile Val Ser Thr Gly Ile Leu Met Ser Leu Ser Asn
                805                 810                 815     
Ile Leu Lys Met Thr Ser Pro His Gln Val Val Lys Asp Pro Phe Tyr
            820                 825                 830         
Val Ile Glu Ser Leu Ser Asp Thr Ile Leu Ala Asn Lys Val Pro Gly
        835                 840                 845             
Asn Lys Thr Thr Ser Met Arg Thr Pro Asn Phe Asn Met Tyr Val Lys
    850                 855                 860                 
Lys Val Glu Lys Trp Gly Ile Asn Gln Leu Phe Arg Asn Glu Lys His
865                 870                 875                 880 
Cys Arg Asn Cys Phe Tyr Pro Thr Leu Asn Val Ser Ser Val Pro Gly
                885                 890                 895     
Leu Ser Ala Asn Gly Pro Ile Ser Thr Met Phe Cys Asp Phe Thr Asn
            900                 905                 910         
Asp Leu Phe Pro Trp Leu Asn Asp Gln Glu Asn Thr Ser Val Glu Val
        915                 920                 925             
Ser Gly Phe Arg Met Thr Gly Val Ala Asp Asn Gly Ser Val Leu Glu
    930                 935                 940                 
Ile Thr Pro Asp Val Ala Glu Val Tyr Leu Val Arg Lys Asn Leu Thr
945                 950                 955                 960 
Phe Ala Ala Phe Asn Leu Thr Val Gly Pro Asn Ser Glu Val Asp Gly
                965                 970                 975     
Ser Leu Lys Lys Thr Thr Gly Gly Phe Ser Phe Gln Val Asp Ser Thr
            980                 985                 990         
Val Leu Arg Glu Val Leu Val His Ile Val Thr Glu Val Met Val Leu
        995                 1000                1005            
Phe Thr Val Leu Val Tyr Thr Gly Ser Gln Ile Thr Pro Thr Ala Leu
    1010                1015                1020                
Val Ala Thr Phe Leu Val Pro His Asp Ile Pro Pro Phe Ala Ser Gln
1025                1030                1035                1040
Ser Ala Leu Phe Asp Pro Ala Cys Thr Val Lys Lys Ala Arg Val Val
                1045                1050                1055    
Cys Leu Pro Val Ser Leu Leu Gln Leu Ile Ala Gln His Ser His Ser
            1060                1065                1070        
Pro His Cys Thr Val Ser Ile Val Leu Gln Ala Pro Arg Phe Val Met
        1075                1080                1085            
Lys Leu Asn Asp Lys Leu Val Arg Ile Ser Ile Phe Ser Val Gln Cys
    1090                1095                1100                
Leu Asp Met Tyr Gly Ile Gln Ser Glu Trp Arg Glu Gly Tyr Cys Ile
1105                1110                1115                1120
Leu Gly Glu Lys Thr Ser Trp Tyr Glu Val His Cys Ile Cys Lys Asn
                1125                1130                1135    
Val Val Arg Ala Arg Arg Gln Leu Gly Thr Ile Gly Leu Thr Gly Ile
            1140                1145                1150        
His Leu His Thr His Tyr Val Met Ala Lys Val Ile Val Ile Pro Asn
        1155                1160                1165            
Pro Val Asp Leu Arg Leu Asn Ile Ile Lys Ser Leu His Gln Asn Pro
    1170                1175                1180                
Val Thr Leu Phe Thr Val Leu Phe Ile Ile Leu Leu Tyr Val Gly Leu
1185                1190                1195                1200
Ala Phe Trp Ala Leu Tyr Arg Asp Glu Met Asp Gln His Leu Arg Gly
                1205                1210                1215    
His Val Ile Val Leu Pro Asp Asn Asp Pro Tyr Asp Asn Leu Cys Tyr
            1220                1225                1230        
Leu Val Thr Ile Phe Thr Gly Ser Arg Trp Gly Ser Gly Thr Arg Ala
        1235                1240                1245            
Asn Val Phe Val Gln Leu Arg Gly Thr Val Ser Thr Ser Asp Val His
    1250                1255                1260                
Cys Leu Ser His Pro His Phe Thr Thr Leu Tyr Arg Gly Ser Ile Asn
1265                1270                1275                1280
Thr Phe Leu Leu Thr Thr Lys Ser Asp Leu Gly Asp Ile His Ser Ile
                1285                1290                1295    
Arg Val Trp His Asn Asn Glu Gly Arg Ser Pro Ser Trp Tyr Leu Ser
            1300                1305                1310        
Arg Ile Lys Val Glu Asn Leu Phe Ser Arg His Ile Trp Leu Phe Ile
        1315                1320                1325            
Cys Gln Lys Trp Leu Ser Val Asp Thr Thr Leu Asp Arg Thr Phe His
    1330                1335                1340                
Val Thr His Pro Asp Glu Arg Leu Thr Arg Lys Asp Phe Phe Phe Ile
1345                1350                1355                1360
Asp Val Ser Ser Asn Leu Arg Lys Asn His Met Trp Phe Ser Ile Phe
                1365                1370                1375    
Ala Ser Val Val Ala Lys Thr Phe Asn Arg Leu Gln Arg Leu Ser Cys
            1380                1385                1390        
Cys Leu Ala Met Leu Leu Ser Ser Leu Leu Cys Asn Ile Met Phe Phe
        1395                1400                1405            
Asn Leu Asn Arg Gln Glu Gln Thr Glu Ser Arg Glu Arg Lys Tyr Met
    1410                1415                1420                
Arg Ser Met Met Ile Gly Ile Glu Ser Val Leu Ile Thr Ile Pro Val
1425                1430                1435                1440
Gln Leu Leu Ile Thr Phe Leu Phe Thr Cys Ser Gln Arg Lys Pro Gln
                1445                1450                1455    
Ala Asp Leu Lys Glu Val Ser Pro Gln Lys His Pro Leu Met Ser Glu
            1460                1465                1470        
Ala Ser Glu His Trp Glu Glu Tyr Leu Arg Lys Trp His Ala Tyr Glu
        1475                1480                1485            
Thr Ala Lys Val His Pro Arg Glu Val Ala Lys Pro Ala Ser Lys Gly
    1490                1495                1500                
Lys Pro Arg Leu Pro Lys Ala Ser Pro Lys Ala Thr Ser Lys Pro Lys
1505                1510                1515                1520
His Arg His Arg Lys Ala Gln Ile Lys Thr Pro Glu Thr Leu Gly Pro
                1525                1530                1535    
Asn Thr Asn Ser Asn Asn Asn Ile Glu Asp Asp Gln Asp Val His Ser
            1540                1545                1550        
Glu Gln His Pro Ser Gln Lys Asp Leu Gln Gln Leu Lys Lys Lys Pro
        1555                1560                1565            
Arg Ile Val Leu Pro Trp Trp Cys Val Tyr Val Ala Trp Phe Leu Val
    1570                1575                1580                
Phe Ala Thr Ser Ser Ile Ser Ser Phe Phe Ile Val Phe Tyr Gly Leu
1585                1590                1595                1600
Thr Tyr Gly Tyr Asp Lys Ser Ile Glu Trp Leu Phe Ala Ser Phe Cys
                1605                1610                1615    
Ser Phe Cys Gln Ser Val Leu Leu Val Gln Pro Ser Lys Ile Ile Leu
            1620                1625                1630        
Leu Ser Gly Phe Arg Thr Asn Lys Pro Lys Tyr Cys Lys Asn Leu Ser
        1635                1640                1645            
Trp Ser Thr Lys Tyr Lys Tyr Thr Glu Ile Arg Leu Asp Gly Met Arg
    1650                1655                1660                
Met His Pro Glu Glu Met Gln Arg Ile His Asp Gln Ile Val Arg Ile
1665                1670                1675                1680
Arg Gly Thr Arg Met Tyr Gln Pro Leu Thr Glu Asp Glu Ile Arg Ile
                1685                1690                1695    
Phe Lys Arg Lys Lys Arg Ile Lys Arg Arg Ala Leu Leu Phe Leu Ser
            1700                1705                1710        
Tyr Ile Leu Thr His Phe Ile Phe Leu Ala Leu Leu Leu Ile Leu Ile
        1715                1720                1725            
Val Leu Leu Arg His Thr Asp Cys Phe Tyr Tyr Asn Gln Phe Ile Arg
    1730                1735                1740                
Asp Arg Phe Ser Met Asp Leu Ala Thr Val Thr Lys Leu Glu Asp Ile
1745                1750                1755                1760
Tyr Arg Trp Leu Asn Ser Val Leu Leu Pro Leu Leu His Asn Asp Leu
                1765                1770                1775    
Asn Pro Thr Phe Leu Pro Glu Ser Ser Ser Lys Ile Leu Gly Leu Pro
            1780                1785                1790        
Leu Met Arg Gln Val Arg Ala Lys Ser Ser Glu Lys Met Cys Leu Pro
        1795                1800                1805            
Ala Glu Lys Phe Val Gln Asn Ser Ile Arg Arg Glu Ile His Cys His
    1810                1815                1820                
Pro Lys Tyr Gly Ile Asp Pro Glu Asp Thr Lys Asn Tyr Ser Gly Phe
1825                1830                1835                1840
Trp Asn Glu Val Asp Lys Gln Ala Ile Asp Glu Ser Thr Asn Gly Phe
                1845                1850                1855    
Thr Tyr Lys Pro Gln Gly Thr Gln Trp Leu Tyr Tyr Ser Tyr Gly Leu
            1860                1865                1870        
Leu His Thr Tyr Gly Ser Gly Gly Tyr Ala Leu Tyr Phe Phe Pro Glu
        1875                1880                1885            
Gln Gln Arg Phe Asn Ser Thr Leu Arg Leu Lys Glu Leu Gln Glu Ser
    1890                1895                1900                
Asn Trp Leu Asp Glu Lys Thr Trp Ala Val Val Leu Glu Leu Thr Thr
1905                1910                1915                1920
Phe Asn Pro Asp Ile Asn Leu Phe Cys Ser Ile Ser Val Ile Phe Glu
                1925                1930                1935    
Val Ser Gln Leu Gly Val Val Asn Thr Ser Ile Ser Leu His Ser Phe
            1940                1945                1950        
Ser Leu Ala Asp Phe Asp Arg Lys Ala Ser Ala Glu Ile Tyr Leu Tyr
        1955                1960                1965            
Val Ala Ile Leu Ile Phe Phe Leu Ala Tyr Val Val Asp Glu Gly Cys
    1970                1975                1980                
Ile Ile Met Gln Glu Arg Ala Ser Tyr Val Arg Ser Val Tyr Asn Leu
1985                1990                1995                2000
Leu Asn Phe Ala Leu Lys Cys Ile Phe Thr Val Leu Ile Val Leu Phe
                2005                2010                2015    
Leu Arg Lys His Phe Leu Ala Thr Gly Ile Ile Arg Phe Tyr Leu Ser
            2020                2025                2030        
Asn Pro Glu Asp Phe Ile Pro Phe His Ala Val Ser Gln Val Asp His
        2035                2040                2045            
Ile Met Arg Ile Ile Leu Gly Phe Leu Leu Phe Leu Thr Ile Leu Lys
    2050                2055                2060                
Thr Leu Arg Tyr Ser Arg Phe Phe Tyr Asp Val Arg Leu Ala Gln Arg
2065                2070                2075                2080
Ala Ile Gln Ala Ala Leu Pro Gly Ile Cys His Met Ala Phe Val Val
                2085                2090                2095    
Ser Val Tyr Phe Phe Val Tyr Met Ala Phe Gly Tyr Leu Val Phe Gly
            2100                2105                2110        
Gln His Glu Trp Asn Tyr Ser Asn Leu Ile His Ser Thr Gln Thr Val
        2115                2120                2125            
Phe Ser Tyr Cys Val Ser Ala Phe Gln Asn Thr Glu Phe Ser Asn Asn
    2130                2135                2140                
Arg Ile Leu Gly Val Leu Phe Leu Ser Ser Phe Met Leu Val Met Ile
2145                2150                2155                2160
Cys Val Leu Ile Asn Leu Phe Gln Ala Val Ile Leu Ser Ala Tyr Glu
                2165                2170                2175    
Glu Met Lys Gln Pro Val Tyr Glu Glu Pro Ser Asp Glu Val Glu Ala
            2180                2185                2190        
Met Thr Tyr Leu Cys Arg Lys Leu Arg Thr Met Phe Ser Phe Leu Thr
        2195                2200                2205            
Ser Gln Ser Lys Ala Lys Asp Glu Pro Glu Phe Phe Ile Asp Met Leu
    2210                2215                2220                
Tyr Gly Gln Pro Glu Lys Asn Ser His Arg Tyr Leu Gly Leu Lys Thr
2225                2230                2235                2240
Arg Asn Ile Asn Gly Lys Lys Met Val Tyr Leu Val Val
                2245                2250            


<210> 9395
<211> 760
<212> PRT
<213> Homo sapiens

<400> 9395
Asn Thr Val Arg Asn Ser Arg Ser Thr Glu Val Ser Gly His Leu Leu
 1               5                  10                  15      
Glu Thr Gly Arg His Leu Val Ser Ala Ala Met Pro Lys Val Met Lys
            20                  25                  30          
Asp Val Val His Pro Leu Gly Gly Glu Glu Pro Ser Met Ala Arg Ala
        35                  40                  45              
Val Val Arg Ser Val Gly Gly Phe Thr Leu Gly Leu Ser Leu Ala Thr
    50                  55                  60                  
Ala Tyr Gly Leu Leu Glu Leu Leu Val Glu Gly His Ser Pro Trp Gly
65                  70                  75                  80  
Cys Leu Val Gly Thr Leu Thr Leu Ala Ala Phe Leu Ser Leu Gly Met
                85                  90                  95      
Gly Phe Ser Arg Gln Val Arg Ala Thr Val Leu Leu Leu Leu Pro Gln
            100                 105                 110         
Ala Phe Ser Arg Gln Gly Arg Thr Leu Leu Leu Val Ala Ala Phe Gly
        115                 120                 125             
Leu Val Leu Gln Gly Pro Cys Ala Asn Thr Leu Arg Asn Phe Thr Arg
    130                 135                 140                 
Ala Ser Glu Ala Val Ala Cys Gly Ala Glu Leu Ala Leu Asn Gln Thr
145                 150                 155                 160 
Ala Glu Val Leu Gln Arg Ala Lys Gln Pro Leu Val Ser Ala Leu Asn
                165                 170                 175     
Lys Ile Lys Ala Ile Ala Arg Lys Thr Lys Glu Val Ala Asp Arg Val
            180                 185                 190         
Arg Lys Phe Phe Arg Ser Ile Met Asp Gly Val Lys His Ile Ala Arg
        195                 200                 205             
Ala Leu Arg Asn Val Trp Gln Trp Leu Leu His Ile Gly Asp Val Cys
    210                 215                 220                 
Asn Ser Glu Leu Gly Asn Pro Tyr Leu Lys Cys Ala Arg Val Phe Asp
225                 230                 235                 240 
Asp Ala Lys Asp Ser Cys Met Met Val Ile Pro Gln Ala Tyr His Leu
                245                 250                 255     
Cys Tyr Val Leu Met Pro Phe Lys Leu Ala Leu Cys Gly Leu Ala Ser
            260                 265                 270         
Leu Val Gln Val Phe Cys Val Ile Pro Lys Tyr Ile Gln Pro Phe Leu
        275                 280                 285             
Arg Gln Thr Ile Gly Thr Pro Val Ile Gln Leu Leu Asn Arg Val Arg
    290                 295                 300                 
Gln Glu Phe Glu Phe Asn Met Thr Ala Thr His His Phe Ser Val Asp
305                 310                 315                 320 
Leu Asn Ala Ser Arg Ser Leu Ser Gln Val Ala Met Asp Leu His Glu
                325                 330                 335     
Ala Val Ser Met Lys Leu His Arg Val Arg Glu Ala Leu Ala Leu Met
            340                 345                 350         
Gly Phe Thr Thr Pro Leu Leu Leu Val Leu Leu Tyr Leu Gln Ala Leu
        355                 360                 365             
Phe Tyr Arg Tyr Cys Tyr Leu Asn Trp Asp His Tyr Asp Asn Ile Tyr
    370                 375                 380                 
Ile Thr Ser Arg Phe Leu Arg Met Glu Ala Val Arg Ser Thr Ala Gly
385                 390                 395                 400 
Leu Pro Thr Val Leu Pro Leu Ser Ala His Glu Ala Arg Arg Tyr Ile
                405                 410                 415     
Pro Pro Gly Ser Ile Phe Leu Ser Gln Trp Glu Lys Phe Phe Tyr Ile
            420                 425                 430         
Leu Glu Thr Phe Asn Leu Ile Arg His Leu Leu Leu Val Leu Phe Leu
        435                 440                 445             
Val Phe Leu Asp Tyr Ala Val Phe Trp Val Leu Asp Leu Ala Arg His
    450                 455                 460                 
Gln Leu Gln Gly Glu Ile Val Ala Arg Ser Pro Val Leu Val Ser Leu
465                 470                 475                 480 
Thr Val Glu Gly Thr Gly Tyr Ala Gly Asn Ile Tyr Arg Asp Leu Val
                485                 490                 495     
Ser Ala Phe Asp Val Leu Gln Gln Gly Asn Ile Ser Ile Leu Ser Arg
            500                 505                 510         
Arg Cys Leu Leu Arg Pro Ser Glu Pro Asp Ser Thr Gly Tyr Ile Val
        515                 520                 525             
Ile Gly Val Met Tyr Gly Leu Cys Phe Phe Ile Thr Leu Phe Gly Ser
    530                 535                 540                 
Tyr Val Ser Arg Leu Arg Arg Val Ile Cys Ala Ser Tyr Tyr Pro Ser
545                 550                 555                 560 
Arg Glu Gln Glu Arg Ile Ser Tyr Leu Tyr Asn Val Leu Leu Ser Arg
                565                 570                 575     
Arg Thr Asn Leu Leu Ala Ala Leu His Arg Ser Val Arg Arg Arg Ala
            580                 585                 590         
Ala Asp Gln Gly His Arg Ser Ala Phe Leu Val Leu Ala Ser Arg Cys
        595                 600                 605             
Pro Cys Leu Gly Pro Phe Val Ser His Phe Trp Leu His Gln Ala Tyr
    610                 615                 620                 
Cys Leu Gly Cys Gly Gln Pro Gln Asp Glu Gly Asp Met Glu Asn Thr
625                 630                 635                 640 
Val Ser Cys Ser Thr Pro Gly Cys Gln Gly Leu Tyr Cys Leu Thr Cys
                645                 650                 655     
Phe Arg Leu Leu Asp Asn Thr Cys Ser Val Cys Ala Ser Pro Leu Ser
            660                 665                 670         
Tyr Gln Gly Asp Leu Asp Leu Glu Leu Asp Ser Ser Asp Glu Glu Gly
        675                 680                 685             
Pro Gln Leu Trp Leu Ala Ala Ala Gln Arg Lys Asp Pro Glu Gln Ala
    690                 695                 700                 
Trp Leu Leu Gln Gln Gln Leu Gln Glu Val Leu Gly Arg Ser Leu Ser
705                 710                 715                 720 
Met Glu Ser Thr Ser Glu Ser Ser Asp Leu Asp Glu Glu Lys Gly Pro
                725                 730                 735     
Gln Gln Arg Lys His Gly Gln Gln Pro Leu Pro Glu Ala His Gln Pro
            740                 745                 750         
Val Ser Ile Leu Thr Ser Pro Glu
        755                 760 


<210> 9396
<211> 604
<212> PRT
<213> Homo sapiens

<400> 9396
Met Asp Gly Val Lys His Ile Ala Arg Ala Leu Arg Asn Val Trp Gln
 1               5                  10                  15      
Trp Leu Leu His Ile Gly Asp Val Cys Asn Ser Glu Leu Gly Asn Pro
            20                  25                  30          
Tyr Leu Lys Cys Ala Arg Val Phe Asp Asp Ala Lys Asp Ser Cys Met
        35                  40                  45              
Met Val Ile Pro Gln Ala Tyr His Leu Cys Tyr Val Leu Met Pro Phe
    50                  55                  60                  
Lys Leu Ala Leu Cys Gly Leu Ala Ser Leu Val Gln Val Phe Cys Val
65                  70                  75                  80  
Ile Pro Lys Tyr Ile Gln Pro Phe Leu Arg Gln Thr Ile Gly Thr Pro
                85                  90                  95      
Val Ile Gln Leu Leu Asn Arg Val Arg Gln Glu Phe Glu Phe Asn Met
            100                 105                 110         
Thr Ala Thr His His Phe Ser Val Asp Leu Asn Ala Ser Arg Ser Leu
        115                 120                 125             
Ser Gln Val Ala Met Asp Leu His Glu Ala Val Ser Met Lys Leu His
    130                 135                 140                 
Arg Val Arg Glu Ala Leu Ala Leu Met Gly Phe Thr Thr Pro Leu Leu
145                 150                 155                 160 
Leu Val Leu Leu Tyr Leu Gln Ala Leu Phe Tyr Arg Tyr Cys Tyr Leu
                165                 170                 175     
Asn Trp Asp His Tyr Asp Asn Ile Tyr Ile Thr Ser Arg Phe Leu Arg
            180                 185                 190         
Met Glu Ala Val Arg Ser Thr Ala Gly Leu Pro Thr Val Leu Pro Leu
        195                 200                 205             
Ser Ala His Glu Ala Arg Arg Tyr Ile Pro Pro Gly Ser Ile Phe Leu
    210                 215                 220                 
Ser Gln Trp Glu Lys Phe Phe Tyr Ile Leu Glu Thr Phe Asn Leu Ile
225                 230                 235                 240 
Arg His Leu Leu Leu Val Leu Phe Leu Val Phe Leu Asp Tyr Ala Val
                245                 250                 255     
Phe Trp Val Leu Asp Leu Ala Arg His Gln Leu Gln Gly Glu Ile Val
            260                 265                 270         
Ala Arg Ser Pro Val Leu Val Ser Leu Thr Val Glu Gly Thr Gly Tyr
        275                 280                 285             
Ala Gly Asn Ile Tyr Arg Asp Leu Val Ser Ala Phe Asp Val Leu Gln
    290                 295                 300                 
Gln Gly Asn Ile Ser Ile Leu Ser Arg Arg Cys Leu Leu Arg Pro Ser
305                 310                 315                 320 
Glu Pro Asp Ser Thr Gly Tyr Ile Val Ile Gly Val Met Tyr Gly Leu
                325                 330                 335     
Cys Phe Phe Ile Thr Leu Phe Gly Ser Tyr Val Ser Arg Leu Arg Arg
            340                 345                 350         
Val Ile Cys Ala Ser Tyr Tyr Pro Ser Arg Glu Gln Glu Arg Ile Ser
        355                 360                 365             
Tyr Leu Tyr Asn Val Leu Leu Ser Arg Arg Thr Asn Leu Leu Ala Ala
    370                 375                 380                 
Leu His Arg Ser Val Arg Arg Arg Ala Ala Asp Gln Gly His Arg Ser
385                 390                 395                 400 
Ala Phe Leu Val Leu Ala Ser Arg Cys Pro Cys Leu Gly Pro Phe Val
                405                 410                 415     
Ser His Phe Trp Leu His Gln Ala Tyr Cys Leu Gly Cys Gly Gln Pro
            420                 425                 430         
Gln Asp Glu Gly Asp Met Glu Asn Thr Val Ser Cys Ser Thr Pro Gly
        435                 440                 445             
Cys Gln Gly Leu Tyr Cys Leu Thr Cys Phe Arg Leu Leu Asp Asn Thr
    450                 455                 460                 
Cys Ser Val Cys Ala Ser Pro Leu Ser Tyr Gln Gly Asp Leu Asp Leu
465                 470                 475                 480 
Glu Leu Asp Ser Ser Asp Glu Glu Gly Pro Gln Leu Trp Leu Ala Ala
                485                 490                 495     
Ala Gln Arg Lys Asp Pro Glu Gln Ala Trp Leu Leu Gln Gln Gln Leu
            500                 505                 510         
Gln Glu Val Leu Gly Arg Ser Leu Ser Met Glu Ser Thr Ser Glu Ser
        515                 520                 525             
Ser Asp Leu Asp Glu Glu Lys Gly Pro Gln Gln Arg Lys His Gly Gln
    530                 535                 540                 
Gln Pro Leu Pro Glu Ala His Gln Pro Val Ser Ile Leu Thr Ser Pro
545                 550                 555                 560 
Glu Pro Thr Asp His Leu Arg His Pro Pro Pro Leu Lys Glu Pro Pro
                565                 570                 575     
Leu Gln Leu Gln Asn Pro Gln Ser Leu Ser His Leu Pro Leu Phe Leu
            580                 585                 590         
Ile Leu Pro Thr His Pro Pro Asn Lys Pro Lys Val
        595                 600                 


<210> 9397
<211> 639
<212> PRT
<213> Homo sapiens

<400> 9397
Met Pro Lys Val Met Lys Asp Val Val His Pro Leu Gly Gly Glu Glu
 1               5                  10                  15      
Pro Ser Met Ala Arg Ala Val Val Arg Ser Val Gly Gly Phe Thr Leu
            20                  25                  30          
Gly Leu Ser Leu Ala Thr Ala Tyr Gly Leu Leu Glu Leu Leu Val Glu
        35                  40                  45              
Gly His Ser Pro Trp Gly Cys Leu Val Gly Thr Leu Thr Leu Ala Ala
    50                  55                  60                  
Phe Leu Ser Leu Gly Met Gly Phe Ser Arg Gln Val Arg Ala Thr Val
65                  70                  75                  80  
Leu Leu Leu Leu Pro Gln Ala Phe Ser Arg Gln Gly Arg Thr Leu Leu
                85                  90                  95      
Leu Val Ala Ala Phe Gly Leu Val Leu Gln Gly Pro Cys Ala Asn Thr
            100                 105                 110         
Leu Arg Asn Phe Thr Arg Ala Ser Glu Ala Val Ala Cys Gly Ala Glu
        115                 120                 125             
Leu Ala Leu Asn Gln Thr Ala Glu Val Leu Gln Arg Ala Lys Gln Pro
    130                 135                 140                 
Leu Val Ser Ala Leu Asn Lys Ile Lys Ala Ile Ala Arg Lys Thr Lys
145                 150                 155                 160 
Glu Val Ala Asp Arg Val Arg Lys Phe Phe Arg Ser Ile Met Asp Gly
                165                 170                 175     
Val Lys His Ile Ala Arg Ala Leu Arg Asn Val Trp Gln Trp Leu Leu
            180                 185                 190         
His Ile Gly Asp Val Cys Asn Ser Glu Leu Gly Asn Pro Tyr Leu Lys
        195                 200                 205             
Cys Ala Arg Val Phe Asp Asp Ala Lys Asp Ser Cys Met Met Val Ile
    210                 215                 220                 
Pro Gln Ala Tyr His Leu Cys Tyr Val Leu Met Pro Phe Lys Leu Ala
225                 230                 235                 240 
Leu Cys Gly Leu Ala Ser Leu Val Gln Val Phe Cys Val Ile Pro Lys
                245                 250                 255     
Tyr Ile Gln Pro Phe Leu Arg Gln Thr Ile Gly Thr Pro Val Ile Gln
            260                 265                 270         
Leu Leu Asn Arg Val Arg Gln Glu Phe Glu Phe Asn Met Thr Ala Thr
        275                 280                 285             
His His Phe Ser Val Asp Leu Asn Ala Ser Arg Ser Leu Ser Gln Val
    290                 295                 300                 
Ala Met Asp Leu His Glu Ala Val Ser Met Lys Leu His Arg Val Arg
305                 310                 315                 320 
Glu Ala Leu Ala Leu Met Gly Phe Thr Thr Pro Leu Leu Leu Val Leu
                325                 330                 335     
Leu Tyr Leu Gln Ala Leu Phe Tyr Arg Tyr Cys Tyr Leu Asn Trp Asp
            340                 345                 350         
His Tyr Asp Asn Ile Tyr Ile Thr Ser Arg Phe Leu Arg Met Glu Ala
        355                 360                 365             
Val Arg Ser Thr Ala Gly Leu Pro Thr Val Leu Pro Leu Ser Ala His
    370                 375                 380                 
Glu Ala Arg Arg Tyr Ile Pro Pro Gly Ser Ile Phe Leu Ser Gln Trp
385                 390                 395                 400 
Glu Lys Phe Phe Tyr Ile Leu Glu Thr Phe Asn Leu Ile Arg His Leu
                405                 410                 415     
Leu Leu Val Leu Phe Leu Val Phe Leu Asp Tyr Ala Val Phe Trp Val
            420                 425                 430         
Leu Asp Leu Ala Arg His Gln Leu Gln Gly Glu Ile Val Ala Arg Ser
        435                 440                 445             
Pro Val Leu Val Ser Leu Thr Val Glu Gly Thr Gly Tyr Ala Gly Asn
    450                 455                 460                 
Ile Tyr Arg Asp Leu Val Ser Ala Phe Asp Val Leu Gln Gln Gly Asn
465                 470                 475                 480 
Ile Ser Ile Leu Ser Arg Arg Cys Leu Leu Arg Pro Ser Glu Pro Asp
                485                 490                 495     
Ser Thr Gly Tyr Ile Val Ile Gly Val Met Tyr Gly Leu Cys Phe Phe
            500                 505                 510         
Ile Thr Leu Phe Gly Ser Tyr Val Ser Arg Leu Arg Arg Val Ile Cys
        515                 520                 525             
Ala Ser Tyr Tyr Pro Ser Arg Glu Gln Glu Arg Ile Ser Tyr Leu Tyr
    530                 535                 540                 
Asn Val Leu Leu Ser Arg Arg Thr Asn Leu Leu Ala Ala Leu His Arg
545                 550                 555                 560 
Ser Val Arg Arg Arg Ala Ala Asp Gln Gly His Arg Ser Ala Phe Leu
                565                 570                 575     
Val Leu Ala Ser Arg Cys Pro Cys Leu Gly Pro Phe Val Ser His Phe
            580                 585                 590         
Trp Leu His Gln Ala Tyr Cys Leu Gly Cys Gly Gln Pro Gln Asp Glu
        595                 600                 605             
Gly Asp Met Glu Asn Thr Val Ser Cys Ser Thr Pro Gly Cys Gln Gly
    610                 615                 620                 
Phe Ile Cys Lys Trp His Cys Ser Ser Ser Leu Val Cys Thr Pro
625                 630                 635                 


<210> 9398
<211> 489
<212> PRT
<213> Homo sapiens

<400> 9398
Met Thr Ala Thr His His Phe Ser Val Asp Leu Asn Ala Ser Arg Ser
 1               5                  10                  15      
Leu Ser Gln Val Ala Met Asp Leu His Glu Ala Val Ser Met Lys Leu
            20                  25                  30          
His Arg Val Arg Glu Ala Leu Ala Leu Met Gly Phe Thr Thr Pro Leu
        35                  40                  45              
Leu Leu Val Leu Leu Tyr Leu Gln Ala Leu Phe Tyr Arg Tyr Cys Tyr
    50                  55                  60                  
Leu Asn Trp Asp His Tyr Asp Asn Ile Tyr Ile Thr Ser Arg Phe Leu
65                  70                  75                  80  
Arg Met Glu Ala Val Arg Ser Thr Ala Gly Leu Pro Thr Val Leu Pro
                85                  90                  95      
Leu Ser Ala His Glu Ala Arg Arg Tyr Ile Pro Pro Gly Ser Ile Phe
            100                 105                 110         
Leu Ser Gln Trp Glu Lys Phe Phe Tyr Ile Leu Glu Thr Phe Asn Leu
        115                 120                 125             
Ile Arg His Leu Leu Leu Val Leu Phe Leu Val Phe Leu Asp Tyr Ala
    130                 135                 140                 
Val Phe Trp Val Leu Asp Leu Ala Arg His Gln Leu Gln Gly Glu Ile
145                 150                 155                 160 
Val Ala Arg Ser Pro Val Leu Val Ser Leu Thr Val Glu Gly Thr Gly
                165                 170                 175     
Tyr Ala Gly Asn Ile Tyr Arg Asp Leu Val Ser Ala Phe Asp Val Leu
            180                 185                 190         
Gln Gln Gly Asn Ile Ser Ile Leu Ser Arg Arg Cys Leu Leu Arg Pro
        195                 200                 205             
Ser Glu Pro Asp Ser Thr Gly Tyr Ile Val Ile Gly Val Met Tyr Gly
    210                 215                 220                 
Leu Cys Phe Phe Ile Thr Leu Phe Gly Ser Tyr Val Ser Arg Leu Arg
225                 230                 235                 240 
Arg Val Ile Cys Ala Ser Tyr Tyr Pro Ser Arg Glu Gln Glu Arg Ile
                245                 250                 255     
Ser Tyr Leu Tyr Asn Val Leu Leu Ser Arg Arg Thr Asn Leu Leu Ala
            260                 265                 270         
Ala Leu His Arg Ser Val Arg Arg Arg Ala Ala Asp Gln Gly His Arg
        275                 280                 285             
Ser Ala Phe Leu Val Leu Ala Ser Arg Cys Pro Cys Leu Gly Pro Phe
    290                 295                 300                 
Val Ser His Phe Trp Leu His Gln Ala Tyr Cys Leu Gly Cys Gly Gln
305                 310                 315                 320 
Pro Gln Asp Glu Gly Asp Met Glu Asn Thr Val Ser Cys Ser Thr Pro
                325                 330                 335     
Gly Cys Gln Gly Leu Tyr Cys Leu Thr Cys Phe Arg Leu Leu Asp Asn
            340                 345                 350         
Thr Cys Ser Val Cys Ala Ser Pro Leu Ser Tyr Gln Gly Asp Leu Asp
        355                 360                 365             
Leu Glu Leu Asp Ser Ser Asp Glu Glu Gly Pro Gln Leu Trp Leu Ala
    370                 375                 380                 
Ala Ala Gln Arg Lys Asp Pro Glu Gln Ala Trp Leu Leu Gln Gln Gln
385                 390                 395                 400 
Leu Gln Glu Val Leu Gly Arg Ser Leu Ser Met Glu Ser Thr Ser Glu
                405                 410                 415     
Ser Ser Asp Leu Asp Glu Glu Lys Gly Pro Gln Gln Arg Lys His Gly
            420                 425                 430         
Gln Gln Pro Leu Pro Glu Ala His Gln Pro Val Ser Ile Leu Thr Ser
        435                 440                 445             
Pro Glu Pro His Arg Pro Pro Glu Thr Ser Ser Ala Thr Lys Gly Ala
    450                 455                 460                 
Pro Thr Pro Ala Ser Glu Pro Ser Val Pro Leu Ser Pro Pro Ser Leu
465                 470                 475                 480 
Pro Asp Pro Ser His Pro Pro Pro Lys
                485                 


<210> 9399
<211> 340
<212> PRT
<213> Homo sapiens

<400> 9399
Met His Lys Phe Arg Leu Lys Trp Gln Ser Ile Ser Ile Thr Leu Val
 1               5                  10                  15      
Glu Lys Val Gln Met Ile Ala Val Ile Leu Gly Ser Leu Phe Leu Ile
            20                  25                  30          
Ala Ser Val Thr Trp Leu Leu Trp Ser Ala Phe Ser Pro Tyr Ala Val
        35                  40                  45              
Trp Gln Arg Lys Asp Ile Leu Phe Gln Ile Cys Tyr Gly Met Tyr Gly
    50                  55                  60                  
Phe Met Asp Leu Val Cys Ile Gly Ser Asp Phe Leu Ser Cys Lys Ile
65                  70                  75                  80  
Phe Met Asn Lys Tyr Glu Ile Tyr Gln Val Val Ser Ser Glu Glu Cys
                85                  90                  95      
Lys Thr Thr Lys Arg Thr Ile Lys Met Ser Thr Glu Asp Phe Arg Ala
            100                 105                 110         
Tyr Val Val Trp Gly Cys Leu Ser Arg Leu Ser Ser Phe Leu Val Ser
        115                 120                 125             
Leu Trp Arg Ala Lys Thr Thr Arg Ile Gln Cys Gly Leu Ile Arg Asp
    130                 135                 140                 
His Leu His Ser Glu Asp Thr Phe Ser Thr Gly Ser Gly Asp His Ser
145                 150                 155                 160 
Cys Gln Pro Pro Thr Ala Pro Cys Ile Ser Glu Leu Tyr Lys Gln Ser
                165                 170                 175     
Ser Cys Thr Pro Phe Lys Ser Val Ile Asn Phe His Gln Lys Thr Phe
            180                 185                 190         
Ile Thr Arg Leu Leu Glu Pro Lys Ser Asn His Leu Ile Thr Thr Gln
        195                 200                 205             
Ser Pro Pro Pro Leu Pro Ser Leu Glu Ser Glu Leu Leu Gly Ser Leu
    210                 215                 220                 
Arg Ile Ala Glu Leu Trp Lys Leu Thr Gly Leu Ile Val His Glu Gly
225                 230                 235                 240 
Ala Ala Val Tyr Arg Val Phe Lys Arg Trp Arg Ala Val Asn Leu His
                245                 250                 255     
Trp Asp Val Leu Asn Tyr Asp Lys Ala Thr Asp Ile Glu Glu Ser Ser
            260                 265                 270         
Arg Gly Glu Ser Ser Thr Ser Arg Thr Leu Trp Leu Pro Leu Thr Ala
        275                 280                 285             
Leu Arg Asn Arg Asn Leu Val His Pro Thr Gln Leu Thr Ser Pro Arg
    290                 295                 300                 
Phe Gln Cys Gly Tyr Val Leu Leu His Leu Phe Asn Arg Met Arg Pro
305                 310                 315                 320 
His Glu Asp Leu Ser Glu Asp Asn Ser Ser Gly Glu Val Val Met Arg
                325                 330                 335     
Val Thr Ser Val
            340 


<210> 9400
<211> 220
<212> PRT
<213> Homo sapiens

<400> 9400
Met Arg Ser Ser Leu Thr Met Val Gly Thr Leu Trp Ala Phe Leu Ser
 1               5                  10                  15      
Leu Val Thr Ala Val Thr Ser Ser Thr Ser Tyr Phe Leu Pro Tyr Trp
            20                  25                  30          
Leu Phe Gly Ser Gln Met Gly Lys Pro Val Ser Phe Ser Thr Phe Arg
        35                  40                  45              
Arg Cys Asn Tyr Pro Val Arg Gly Glu Gly His Ser Leu Ile Met Val
    50                  55                  60                  
Glu Glu Cys Gly Arg Tyr Ala Ser Phe Asn Ala Ile Pro Ser Leu Ala
65                  70                  75                  80  
Trp Gln Met Cys Thr Val Val Thr Gly Ala Gly Cys Ala Leu Leu Leu
                85                  90                  95      
Leu Val Ala Leu Ala Ala Val Leu Gly Cys Cys Met Glu Glu Leu Ile
            100                 105                 110         
Ser Arg Met Met Gly Arg Cys Met Gly Ala Ala Gln Phe Val Gly Gly
        115                 120                 125             
Leu Leu Ile Ser Ser Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asn Ser
    130                 135                 140                 
Pro Glu Ile Met Gln Thr Cys Gly Asn Val Ser Asn Gln Phe Gln Leu
145                 150                 155                 160 
Gly Thr Cys Arg Leu Gly Trp Ala Tyr Tyr Cys Ala Gly Gly Gly Ala
                165                 170                 175     
Ala Ala Ala Met Leu Ile Cys Thr Trp Leu Ser Cys Phe Ala Gly Arg
            180                 185                 190         
Asn Pro Lys Pro Val Ile Leu Val Glu Ser Ile Met Arg Asn Thr Asn
        195                 200                 205             
Ser Tyr Ala Met Glu Leu Asp His Cys Leu Lys Pro
    210                 215                 220 


<210> 9401
<211> 270
<212> PRT
<213> Homo sapiens

<400> 9401
His Phe Arg Val Ser Asn Ser Ile Ser Arg Ser Arg Gly Phe Ser Ser
 1               5                  10                  15      
Trp Ser Phe Leu Arg Pro Leu Gly Ser Gln Glu Pro Leu Asp Arg Gly
            20                  25                  30          
Arg Asn Glu Gly Ala Pro Gly Cys Glu Ser Arg Gly Ser Leu Lys Arg
        35                  40                  45              
Gly Gly Cys Ser Pro Ser Phe Phe Pro Pro Pro Pro Asp Phe Leu Ile
    50                  55                  60                  
Cys Pro His Leu Pro Val Gly Gly Asp Val Tyr Gly Gln Ile Cys Gly
65                  70                  75                  80  
Leu Gly Thr Met Glu Val Glu Glu Ile Tyr Lys His Gln Glu Val Lys
                85                  90                  95      
Met Gln Ala Pro Ala Phe Arg Asp Lys Lys Gln Gly Val Ser Ala Lys
            100                 105                 110         
Asn Gln Gly Ala His Asp Pro Asp Tyr Glu Asn Ile Thr Leu Ala Phe
        115                 120                 125             
Lys Asn Gln Asp His Ala Lys Gly Gly His Ser Arg Pro Thr Ser Gln
    130                 135                 140                 
Val Pro Ala Gln Cys Arg Pro Pro Ser Asp Ser Thr Gln Val Pro Cys
145                 150                 155                 160 
Trp Leu Tyr Arg Ala Ile Leu Ser Leu Tyr Ile Leu Leu Ala Leu Ala
                165                 170                 175     
Phe Val Leu Cys Ile Ile Leu Ser Ala Phe Ile Met Val Lys Asn Ala
            180                 185                 190         
Glu Met Ser Lys Glu Leu Leu Gly Phe Lys Arg Glu Leu Trp Asn Val
        195                 200                 205             
Ser Asn Ser Val Gln Ala Cys Glu Glu Arg Gln Lys Arg Gly Trp Asp
    210                 215                 220                 
Ser Val Gln Gln Ser Ile Thr Met Val Arg Ser Lys Ile Asp Arg Leu
225                 230                 235                 240 
Glu Thr Thr Leu Ala Gly Ile Lys Asn Ile Asp Thr Lys Val Gln Lys
                245                 250                 255     
Ile Leu Glu Val Leu Gln Lys Met Pro Gln Ser Ser Pro Gln
            260                 265                 270 


<210> 9402
<211> 228
<212> PRT
<213> Homo sapiens

<400> 9402
Met Glu Pro Ala Ser Cys Cys Ala Glu Arg Pro Lys Pro Gly Pro Thr
 1               5                  10                  15      
Gly Val Lys Thr Lys Pro Ser Cys Gly Gly Trp Arg Ala Val Gly Leu
            20                  25                  30          
Leu Leu Leu Leu Leu Leu Leu Val Leu Ala Ala Val Gly Ile Val Ala
        35                  40                  45              
Gly Gly Leu Leu Gly Ser Ala Gln Gly Pro Pro Lys Pro Arg Leu Gln
    50                  55                  60                  
Thr Leu Arg Met Thr Leu Pro Ser Pro His Met Pro Arg Pro Asn Gln
65                  70                  75                  80  
Thr Ile Leu Val Asp Val Ala Arg Asn Ala Ala Thr Ile Thr Val Thr
                85                  90                  95      
Pro Pro Gln Ser Asn His Ser Trp Ala Val Leu Phe Asp Gly Gln Ser
            100                 105                 110         
Gly Cys Ile Cys Tyr Arg Pro Glu Glu His Gln Val Cys Phe Leu Arg
        115                 120                 125             
Leu Met Glu Asp Ser Asp Arg Glu Thr Leu Arg Leu Leu Val Asp Thr
    130                 135                 140                 
Ser Lys Val Gln Glu Ala Trp Val Pro Ser Gln Asp Thr His His Thr
145                 150                 155                 160 
Gln Glu Leu Leu Ala Val Gln Gly Ser Leu Glu Val Asp Pro Ala Gln
                165                 170                 175     
Ala Gly Ala Leu Val Gln Arg Leu Cys Met Arg Thr Pro Ile Tyr Trp
            180                 185                 190         
Ala Arg Arg Ala Glu Gly Pro Arg Arg Gln Arg Leu Ile Tyr Leu Cys
        195                 200                 205             
Ile Asp Ile Cys Phe Pro Ser Asn Ile Cys Val Ser Val Cys Phe Tyr
    210                 215                 220                 
Tyr Leu Pro Asp
225             


<210> 9403
<211> 353
<212> PRT
<213> Homo sapiens

<400> 9403
Met His Asn Val Phe Lys Lys His Val Val Met Tyr Thr Phe Cys Asn
 1               5                  10                  15      
Tyr Leu Phe Cys Cys Phe Val Ala Thr Ile Cys Lys Thr Phe Gln Met
            20                  25                  30          
Val Ala Pro Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
        35                  40                  45              
Lys Lys Asn Ser Arg Gly Gly Pro Val Pro Gly Asn Leu Leu Pro Ala
    50                  55                  60                  
Leu Ser Gly Gly Pro Arg His Pro Thr Gln Pro Gly Leu Pro Gly Ala
65                  70                  75                  80  
Ser Ala Arg Gly His Ser Pro Arg Leu His Pro Gly Pro Val Ala Arg
                85                  90                  95      
Gly Gly Gly Gly Gly Arg Gln Arg Ala His Val Ala Ala Arg Gly Gly
            100                 105                 110         
Cys His Pro Gly Gly Leu Trp Gly Leu Arg Arg Leu Pro Gly Ala Gly
        115                 120                 125             
Ala Gly Trp Ala Gln Leu Gly Gly Gly Leu Gly Gly Gln Ala Gly Val
    130                 135                 140                 
Gly Ala Gly Gly Arg Gly Gly Asp Ala Leu Pro Gln Pro Ser Ala Ala
145                 150                 155                 160 
Thr Arg Cys Pro His Gln Gly Cys Met Asn Asn Val Thr Leu Gly Asn
                165                 170                 175     
Ala His Met Gly Tyr Tyr Glu Thr Val Ala Gly Gly Ala Gly Ala Gly
            180                 185                 190         
Pro Ser Trp His Gly Arg Ser Gly Val His Ser His Met Thr Asn Thr
        195                 200                 205             
Arg Ile Thr Asp Pro Glu Ile Leu Glu Ser Arg Tyr Pro Val Ile Leu
    210                 215                 220                 
Arg Arg Phe Glu Leu Arg Arg Gly Ser Gly Gly Arg Gly Arg Phe Arg
225                 230                 235                 240 
Gly Gly Asp Gly Val Thr Arg Glu Leu Leu Phe Arg Glu Glu Ala Leu
                245                 250                 255     
Leu Ser Val Leu Thr Glu Arg Arg Ala Phe Arg Pro Tyr Gly Leu His
            260                 265                 270         
Gly Gly Glu Pro Gly Ala Arg Gly Leu Asn Leu Leu Ile Arg Lys Asn
        275                 280                 285             
Gly Arg Thr Val Asn Leu Gly Gly Lys Thr Ser Val Thr Val Tyr Pro
    290                 295                 300                 
Gly Asp Val Phe Cys Leu His Thr Pro Gly Gly Gly Gly Tyr Gly Asp
305                 310                 315                 320 
Pro Glu Asp Pro Ala Pro Pro Pro Gly Ser Pro Pro Gln Ala Leu Ala
                325                 330                 335     
Phe Pro Glu His Gly Ser Val Tyr Glu Tyr Arg Arg Ala Gln Lys Ala
            340                 345                 350         
Val
    


<210> 9404
<211> 894
<212> PRT
<213> Homo sapiens

<400> 9404
Val Pro Arg Gly His Thr Ala Cys Ala Asp Ala Tyr Leu Thr Pro Ala
 1               5                  10                  15      
Ile Gln Arg Tyr Val Gln Gly Phe Cys Arg Gly Phe Gln Gly Gln Leu
            20                  25                  30          
Lys Asp Val Gln Val Leu Phe Met Arg Ser Asp Gly Gly Leu Ala Pro
        35                  40                  45              
Met Asp Thr Phe Ser Gly Ser Ser Ala Val Leu Ser Gly Pro Ala Gly
    50                  55                  60                  
Gly Val Val Gly Tyr Ser Ala Thr Thr Tyr Gln Gln Glu Gly Gly Gln
65                  70                  75                  80  
Pro Val Ile Gly Phe Asp Met Gly Gly Thr Ser Thr Asp Val Ser Arg
                85                  90                  95      
Tyr Ala Gly Glu Phe Glu His Val Phe Glu Ala Ser Thr Ala Gly Val
            100                 105                 110         
Thr Leu Gln Ala Pro Gln Leu Asp Ile Asn Thr Val Ala Ala Gly Gly
        115                 120                 125             
Gly Ser Arg Leu Phe Phe Arg Ser Gly Leu Phe Val Val Gly Pro Glu
    130                 135                 140                 
Ser Ala Gly Ala His Pro Gly Pro Ala Cys Tyr Arg Lys Gly Gly Pro
145                 150                 155                 160 
Val Thr Val Thr Asp Ala Asn Leu Val Leu Gly Arg Leu Leu Pro Ala
                165                 170                 175     
Ser Phe Pro Cys Ile Phe Gly Pro Gly Glu Asn Gln Pro Leu Ser Pro
            180                 185                 190         
Glu Ala Ser Arg Lys Ala Leu Glu Ala Val Ala Thr Glu Val Asn Ser
        195                 200                 205             
Phe Leu Thr Asn Gly Pro Cys Pro Ala Ser Pro Leu Ser Leu Glu Glu
    210                 215                 220                 
Val Ala Met Gly Phe Val Arg Val Ala Asn Glu Ala Met Cys Arg Pro
225                 230                 235                 240 
Ile Arg Ala Leu Thr Gln Val Arg Pro Pro Leu Leu Ser Arg Leu Ser
                245                 250                 255     
Cys Pro Gln Pro Leu Trp Ser Gly Thr Met Arg Glu Phe Gly Phe Val
            260                 265                 270         
Ile Pro Glu Arg Pro Val Val Val Asp Asp Val Arg Val Arg Gly Thr
        275                 280                 285             
Gly Arg Ser Gly Leu Arg Leu Glu Asp Ala Pro Lys Ala Gln Thr Gly
    290                 295                 300                 
Pro Pro Arg Val Asp Lys Met Thr Gln Cys Tyr Phe Glu Gly Gly Tyr
305                 310                 315                 320 
Gln Glu Thr Pro Val Tyr Leu Leu Ala Glu Leu Gly Tyr Gly His Lys
                325                 330                 335     
Leu His Gly Pro Cys Leu Ile Ile Asp Ser Asn Ser Thr Ile Leu Val
            340                 345                 350         
Glu Pro Gly Cys Gln Ala Glu Val Thr Lys Thr Gly Asp Ile Cys Ile
        355                 360                 365             
Ser Val Gly Ala Glu Val Pro Gly Thr Val Gly Pro Gln Leu Asp Pro
    370                 375                 380                 
Ile Gln Leu Ser Ile Phe Ser His Arg Phe Met Ser Ile Ala Glu Gln
385                 390                 395                 400 
Met Gly Arg Ile Leu Gln Arg Thr Ala Ile Ser Thr Asn Ile Lys Glu
                405                 410                 415     
Arg Leu Asp Phe Ser Cys Ala Leu Phe Gly Pro Asp Gly Gly Leu Val
            420                 425                 430         
Ser Asn Ala Pro His Ile Pro Val His Leu Gly Ala Met Gln Glu Thr
        435                 440                 445             
Val Gln Phe Gln Ile Gln His Leu Gly Ala Asp Leu His Pro Gly Asp
    450                 455                 460                 
Val Leu Leu Ser Asn His Pro Ser Ala Gly Gly Ser His Leu Pro Asp
465                 470                 475                 480 
Leu Thr Val Ile Thr Pro Val Phe Trp Pro Gly Gln Thr Arg Pro Val
                485                 490                 495     
Phe Tyr Val Ala Ser Arg Gly His His Ala Asp Ile Gly Gly Ile Thr
            500                 505                 510         
Pro Gly Ser Met Pro Pro His Ser Thr Met Leu Gln Gln Glu Gly Ala
        515                 520                 525             
Val Phe Leu Ser Phe Lys Leu Val Gln Gly Gly Val Phe Gln Glu Glu
    530                 535                 540                 
Ala Val Thr Glu Ala Leu Arg Ala Pro Gly Lys Val Pro Asn Cys Ser
545                 550                 555                 560 
Gly Thr Arg Asn Leu His Asp Asn Leu Ser Asp Leu Arg Ala Gln Val
                565                 570                 575     
Ala Ala Asn Gln Lys Gly Ile Gln Leu Val Gly Glu Leu Ile Gly Gln
            580                 585                 590         
Tyr Gly Leu Asp Val Val Gln Ala Tyr Met Gly His Ile Gln Ala Asn
        595                 600                 605             
Ala Glu Leu Ala Val Arg Asp Met Leu Arg Ala Phe Gly Thr Ser Arg
    610                 615                 620                 
Gln Ala Arg Gly Leu Pro Leu Glu Val Ser Ser Glu Asp His Met Asp
625                 630                 635                 640 
Asp Gly Ser Pro Ile Arg Leu Arg Val Gln Ile Ser Leu Ser Gln Gly
                645                 650                 655     
Ser Ala Val Phe Asp Phe Ser Gly Thr Gly Pro Glu Val Phe Gly Asn
            660                 665                 670         
Leu Asn Ala Pro Arg Ala Val Thr Leu Ser Ala Leu Ile Tyr Cys Leu
        675                 680                 685             
Arg Cys Leu Val Gly Arg Asp Ile Pro Leu Asn Gln Gly Cys Leu Ala
    690                 695                 700                 
Pro Val Arg Val Val Ile Pro Arg Gly Ser Ile Leu Asp Pro Ser Pro
705                 710                 715                 720 
Glu Ala Ala Val Val Gly Gly Asn Val Leu Thr Ser Gln Arg Val Val
                725                 730                 735     
Asp Val Ile Leu Gly Ala Phe Gly Ala Cys Ala Ala Ser Gln Gly Cys
            740                 745                 750         
Met Asn Asn Val Thr Leu Gly Asn Ala His Met Gly Tyr Tyr Glu Thr
        755                 760                 765             
Val Ala Gly Gly Ala Gly Ala Gly Pro Ser Trp His Gly Arg Ser Gly
    770                 775                 780                 
Val His Ser His Met Thr Asn Thr Arg Ile Thr Asp Pro Glu Ile Leu
785                 790                 795                 800 
Glu Ser Arg Tyr Pro Val Ile Leu Arg Arg Phe Glu Leu Arg Arg Gly
                805                 810                 815     
Ser Gly Gly Arg Gly Arg Phe Arg Gly Gly Asp Gly Val Thr Arg Glu
            820                 825                 830         
Leu Leu Phe Arg Glu Glu Ala Leu Leu Ser Val Leu Thr Glu Arg Arg
        835                 840                 845             
Ala Phe Arg Pro Tyr Gly Leu His Gly Ala Arg Phe Pro Ser Pro Arg
    850                 855                 860                 
Gly Pro Pro Arg Pro Arg Pro His Pro Arg Pro Trp Ser Leu Trp Thr
865                 870                 875                 880 
Pro Arg Leu Pro Pro Gln Gly Ala Ser Leu Ala Pro Ala Ala
                885                 890                 


<210> 9405
<211> 529
<212> PRT
<213> Homo sapiens

<400> 9405
Met Ser Glu His Val Glu Pro Ala Ala Pro Gly Pro Gly Pro Asn Gly
 1               5                  10                  15      
Gly Gly Gly Gly Pro Ala Pro Ala Arg Gly Pro Arg Thr Pro Asn Leu
            20                  25                  30          
Asn Pro Asn Pro Leu Ile Asn Val Arg Asp Arg Leu Phe His Ala Leu
        35                  40                  45              
Phe Phe Lys Met Ala Val Thr Tyr Ser Arg Leu Phe Pro Pro Ala Phe
    50                  55                  60                  
Arg Arg Leu Phe Glu Phe Phe Val Leu Leu Lys Ala Leu Phe Val Leu
65                  70                  75                  80  
Phe Val Leu Ala Tyr Ile His Ile Val Phe Ser Arg Ser Pro Ile Asn
                85                  90                  95      
Cys Leu Glu His Val Arg Asp Lys Trp Pro Arg Glu Gly Ile Leu Arg
            100                 105                 110         
Val Glu Val Arg His Asn Ser Ser Arg Ala Pro Val Phe Leu Gln Phe
        115                 120                 125             
Cys Asp Ser Gly Gly Arg Gly Ser Phe Pro Gly Leu Ala Val Glu Pro
    130                 135                 140                 
Gly Ser Asn Leu Asp Met Glu Asp Glu Glu Glu Glu Glu Leu Thr Met
145                 150                 155                 160 
Glu Met Phe Gly Asn Ser Ser Ile Lys Phe Glu Leu Asp Ile Glu Pro
                165                 170                 175     
Lys Val Phe Lys Pro Pro Ser Ser Thr Glu Ala Leu Asn Asp Ser Gln
            180                 185                 190         
Glu Phe Pro Phe Pro Glu Thr Pro Thr Lys Val Trp Pro Gln Asp Glu
        195                 200                 205             
Tyr Ile Val Glu Tyr Ser Leu Glu Tyr Gly Phe Leu Arg Leu Ser Gln
    210                 215                 220                 
Ala Thr Arg Gln Arg Leu Ser Ile Pro Val Met Val Val Thr Leu Asp
225                 230                 235                 240 
Pro Thr Arg Asp Gln Cys Phe Gly Asp Arg Phe Ser Arg Leu Leu Leu
                245                 250                 255     
Asp Glu Phe Leu Gly Tyr Asp Asp Ile Leu Met Ser Ser Val Lys Gly
            260                 265                 270         
Leu Ala Glu Asn Glu Glu Asn Lys Gly Phe Leu Arg Asn Val Val Ser
        275                 280                 285             
Gly Glu His Tyr Arg Phe Val Ser Met Trp Met Ala Arg Thr Ser Tyr
    290                 295                 300                 
Leu Ala Ala Phe Ala Ile Met Val Ile Phe Thr Leu Ser Val Ser Met
305                 310                 315                 320 
Leu Leu Arg Tyr Ser His His Gln Ile Phe Val Phe Ile Val Asp Leu
                325                 330                 335     
Leu Gln Met Leu Glu Met Asn Met Ala Ile Ala Phe Pro Ala Ala Pro
            340                 345                 350         
Leu Leu Thr Val Ile Leu Ala Leu Val Gly Met Glu Ala Ile Met Ser
        355                 360                 365             
Glu Phe Phe Asn Asp Thr Thr Thr Ala Phe Tyr Ile Ile Leu Ile Val
    370                 375                 380                 
Trp Leu Ala Asp Gln Tyr Asp Ala Ile Cys Cys His Thr Ser Thr Ser
385                 390                 395                 400 
Lys Arg His Trp Leu Arg Phe Phe Tyr Leu Tyr His Phe Ala Phe Tyr
                405                 410                 415     
Ala Tyr His Tyr Arg Phe Asn Gly Gln Tyr Ser Ser Leu Ala Leu Val
            420                 425                 430         
Thr Ser Trp Leu Phe Ile Gln His Ser Met Ile Tyr Phe Phe His His
        435                 440                 445             
Tyr Glu Leu Pro Ala Ile Leu Gln Gln Val Arg Ile Gln Glu Met Leu
    450                 455                 460                 
Leu Gln Ala Pro Pro Leu Gly Pro Gly Thr Pro Thr Ala Leu Pro Asp
465                 470                 475                 480 
Asp Met Asn Asn Asn Ser Gly Ala Pro Ala Thr Ala Pro Asp Ser Ala
                485                 490                 495     
Gly Gln Pro Pro Ala Leu Gly Pro Val Phe Glu Leu Val Ser Lys Glu
            500                 505                 510         
Arg Gly Trp Gly Ser Ala Glu Gly Ser Gly Gly Val Leu Val Gly Leu
        515                 520                 525             
Gln
    


<210> 9406
<211> 1494
<212> PRT
<213> Homo sapiens

<400> 9406
Ala Gln Thr Ala Leu Ala Gly Thr Pro Ala Pro Glu Arg Pro Cys Arg
 1               5                  10                  15      
Gly Arg Leu Trp Lys Arg Pro Ala Leu Ser Pro Asn Phe Phe Ser Gly
            20                  25                  30          
Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu Glu Leu
        35                  40                  45              
Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn Leu Ser
    50                  55                  60                  
Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys Lys Asn
65                  70                  75                  80  
Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg Phe Met
                85                  90                  95      
Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala Val Gln
            100                 105                 110         
Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp Asn Lys
        115                 120                 125             
Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys Leu Leu
    130                 135                 140                 
Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly Leu His
145                 150                 155                 160 
His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile Tyr Lys
                165                 170                 175     
Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser Ile Gly
            180                 185                 190         
Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp Glu Gly
        195                 200                 205             
Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val Ala Leu
    210                 215                 220                 
Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe Cys Gly
225                 230                 235                 240 
Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu Gly Arg
                245                 250                 255     
Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser Glu Arg
            260                 265                 270         
Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val Lys Ala
        275                 280                 285             
Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu Arg Gln
    290                 295                 300                 
Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr Phe Asn
305                 310                 315                 320 
Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu Ser Val
                325                 330                 335     
Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile Phe Thr
            340                 345                 350         
Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg Gln Phe
        355                 360                 365             
Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile Asn Lys
    370                 375                 380                 
Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu Tyr Asn
385                 390                 395                 400 
Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe Trp Glu
                405                 410                 415     
Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn Asn Asn
            420                 425                 430         
Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn Phe Ser
        435                 440                 445             
Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile Glu Arg
    450                 455                 460                 
Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys Thr Ser
465                 470                 475                 480 
Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly Lys Ile
                485                 490                 495     
Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp Ile Met
            500                 505                 510         
Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr Asp Glu
        515                 520                 525             
Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu Asp Ile
    530                 535                 540                 
Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly Gly Ile
545                 550                 555                 560 
Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg Ala Val
                565                 570                 575     
Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly Tyr Leu
            580                 585                 590         
Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys Lys Leu
        595                 600                 605             
Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu His Leu
    610                 615                 620                 
Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser Tyr Phe
625                 630                 635                 640 
Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe Ser Ser
                645                 650                 655     
Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu Arg Arg
            660                 665                 670         
Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu Gly Asp
        675                 680                 685             
Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys Gln Thr
    690                 695                 700                 
Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro Ile Asn
705                 710                 715                 720 
Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln Met Asn
                725                 730                 735     
Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu Ser Leu
            740                 745                 750         
Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile Ser Val
        755                 760                 765             
Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser Val Leu
    770                 775                 780                 
Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His Arg Lys
785                 790                 795                 800 
Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala Asn Leu
                805                 810                 815     
Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr Gly Leu
            820                 825                 830         
Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys Phe Phe
        835                 840                 845             
Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr Tyr Leu
    850                 855                 860                 
Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile Trp Cys
865                 870                 875                 880 
Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val Leu Trp
                885                 890                 895     
Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr His Ser
            900                 905                 910         
Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser Tyr Tyr
        915                 920                 925             
Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala Met Gly
    930                 935                 940                 
Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val Ser Lys
945                 950                 955                 960 
Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro Met Ser
                965                 970                 975     
Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe Ser Lys
            980                 985                 990         
Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe Asp Phe
        995                 1000                1005            
Ile Gln Leu Leu Leu Ile Val Ile Gly Ala Ile Ala Val Val Ala Val
    1010                1015                1020                
Leu Gln Pro Tyr Ile Phe Val Ala Thr Val Pro Val Ile Val Ala Phe
1025                1030                1035                1040
Ile Met Leu Arg Ala Tyr Phe Leu Gln Thr Ser Gln Gln Leu Lys Gln
                1045                1050                1055    
Leu Glu Ser Glu Gly Arg Ser Pro Ile Phe Thr His Leu Val Thr Ser
            1060                1065                1070        
Leu Lys Gly Leu Trp Thr Leu Arg Ala Phe Gly Arg Gln Pro Tyr Phe
        1075                1080                1085            
Glu Thr Leu Phe His Lys Ala Leu Asn Leu His Thr Ala Asn Trp Phe
    1090                1095                1100                
Leu Tyr Leu Ser Thr Leu Arg Trp Phe Gln Met Arg Ile Glu Met Ile
1105                1110                1115                1120
Phe Val Ile Phe Phe Ile Ala Val Thr Phe Ile Ser Ile Leu Thr Thr
                1125                1130                1135    
Gly Glu Gly Glu Gly Arg Val Gly Ile Ile Leu Thr Leu Ala Met Asn
            1140                1145                1150        
Ile Met Ser Thr Leu Gln Trp Ala Val Asn Ser Ser Ile Asp Val Asp
        1155                1160                1165            
Ser Leu Met Arg Ser Val Ser Arg Val Phe Lys Phe Ile Asp Met Pro
    1170                1175                1180                
Thr Glu Gly Lys Pro Thr Lys Ser Thr Lys Pro Tyr Lys Asn Gly Gln
1185                1190                1195                1200
Leu Ser Lys Val Met Ile Ile Glu Asn Ser His Val Lys Lys Asp Asp
                1205                1210                1215    
Ile Trp Pro Ser Gly Gly Gln Met Thr Val Lys Asp Leu Thr Ala Lys
            1220                1225                1230        
Tyr Thr Glu Gly Gly Asn Ala Ile Leu Glu Asn Ile Ser Phe Ser Ile
        1235                1240                1245            
Ser Pro Gly Gln Arg Val Gly Leu Leu Gly Arg Thr Gly Ser Gly Lys
    1250                1255                1260                
Ser Thr Leu Leu Ser Ala Phe Leu Arg Leu Leu Asn Thr Glu Gly Glu
1265                1270                1275                1280
Ile Gln Ile Asp Gly Val Ser Trp Asp Ser Ile Thr Leu Gln Gln Trp
                1285                1290                1295    
Arg Lys Ala Phe Gly Val Ile Pro Gln Lys Val Phe Ile Phe Ser Gly
            1300                1305                1310        
Thr Phe Arg Lys Asn Leu Asp Pro Tyr Glu Gln Trp Ser Asp Gln Glu
        1315                1320                1325            
Ile Trp Lys Val Ala Asp Glu Val Gly Leu Arg Ser Val Ile Glu Gln
    1330                1335                1340                
Phe Pro Gly Lys Leu Asp Phe Val Leu Val Asp Gly Gly Cys Val Leu
1345                1350                1355                1360
Ser His Gly His Lys Gln Leu Met Cys Leu Ala Arg Ser Val Leu Ser
                1365                1370                1375    
Lys Ala Lys Ile Leu Leu Leu Asp Glu Pro Ser Ala His Leu Asp Pro
            1380                1385                1390        
Val Thr Tyr Gln Ile Ile Arg Arg Thr Leu Lys Gln Ala Phe Ala Asp
        1395                1400                1405            
Cys Thr Val Ile Leu Cys Glu His Arg Ile Glu Ala Met Leu Glu Cys
    1410                1415                1420                
Gln Gln Phe Leu Val Ile Glu Glu Asn Lys Val Arg Gln Tyr Asp Ser
1425                1430                1435                1440
Ile Gln Lys Leu Leu Asn Glu Arg Ser Leu Phe Arg Gln Ala Ile Ser
                1445                1450                1455    
Pro Ser Asp Arg Val Lys Leu Phe Pro His Arg Asn Ser Ser Lys Cys
            1460                1465                1470        
Lys Ser Lys Pro Gln Ile Ala Ala Leu Lys Glu Glu Thr Glu Glu Glu
        1475                1480                1485            
Val Gln Asp Thr Arg Leu
    1490                


<210> 9407
<211> 2279
<212> PRT
<213> Homo sapiens

<400> 9407
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr
 1               5                  10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe
    1170                1175                1180                
Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val
1185                1190                1195                1200
Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val
                1205                1210                1215    
Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu
            1220                1225                1230        
Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg
        1235                1240                1245            
Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile
    1250                1255                1260                
Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser
1265                1270                1275                1280
Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn
                1285                1290                1295    
Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln
            1300                1305                1310        
Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His
        1315                1320                1325            
Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu
    1330                1335                1340                
Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val
1345                1350                1355                1360
Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln
                1365                1370                1375    
Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile
            1380                1385                1390        
Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp
        1395                1400                1405            
Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser
    1410                1415                1420                
Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe
1425                1430                1435                1440
Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly
                1445                1450                1455    
Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln
            1460                1465                1470        
Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys
        1475                1480                1485            
Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu
    1490                1495                1500                
Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu
1505                1510                1515                1520
Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys
                1525                1530                1535    
Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val
            1540                1545                1550        
Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val
        1555                1560                1565            
Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly
    1570                1575                1580                
Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys
1585                1590                1595                1600
Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys
                1605                1610                1615    
Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn
            1620                1625                1630        
Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser
        1635                1640                1645            
Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr
    1650                1655                1660                
Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala
1665                1670                1675                1680
Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser
                1685                1690                1695    
Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu
            1700                1705                1710        
Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe
        1715                1720                1725            
Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly
    1730                1735                1740                
Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu
1745                1750                1755                1760
Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro
                1765                1770                1775    
Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr
            1780                1785                1790        
Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala
        1795                1800                1805            
Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg
    1810                1815                1820                
Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys
1825                1830                1835                1840
Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp
                1845                1850                1855    
Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp
            1860                1865                1870        
Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val
        1875                1880                1885            
Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln
    1890                1895                1900                
Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp
1905                1910                1915                1920
Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp
                1925                1930                1935    
Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser
            1940                1945                1950        
Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe
        1955                1960                1965            
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met
    1970                1975                1980                
Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly
1985                1990                1995                2000
Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr
                2005                2010                2015    
Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His
            2020                2025                2030        
Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu
        2035                2040                2045            
Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala
    2050                2055                2060                
Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser
2065                2070                2075                2080
Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu
                2085                2090                2095    
Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val
            2100                2105                2110        
Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His
        2115                2120                2125            
Arg Gln Glu Ile Pro Arg Ala Gly Glu Glu Cys Glu Ala Leu Cys Thr
    2130                2135                2140                
Arg Leu Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile
2145                2150                2155                2160
Gln His Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys
                2165                2170                2175    
Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu
            2180                2185                2190        
Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His
        2195                2200                2205            
Tyr Asn Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile
    2210                2215                2220                
Phe Gln Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr
2225                2230                2235                2240
Ser Val Thr Gln Thr Thr Leu Asp Gln Ala Ser Phe Val Asn Phe Ala
                2245                2250                2255    
Lys Gln Gln Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala
            2260                2265                2270        
Gly Ala Ser Arg Gln Ala Gln
        2275                


<210> 9408
<211> 346
<212> PRT
<213> Homo sapiens

<400> 9408
Met Ala Leu Leu Lys Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu
 1               5                  10                  15      
Ala Gln Gly Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile
            20                  25                  30          
Ile Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg
        35                  40                  45              
Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu
    50                  55                  60                  
Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys
65                  70                  75                  80  
Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala Arg Trp Lys Pro
                85                  90                  95      
Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val Leu Phe Asn Ile Ile Leu
            100                 105                 110         
Phe Leu Val Ala Leu Cys Cys Phe Leu Leu Arg Gly Ser Leu Glu Asn
        115                 120                 125             
Thr Leu Gly Gln Gly Leu Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr
    130                 135                 140                 
Asp Thr Pro Gly Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln
145                 150                 155                 160 
Ile Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu
                165                 170                 175     
Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val
            180                 185                 190         
Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val Asp Gly
        195                 200                 205             
Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg Pro Cys Ile Gln
    210                 215                 220                 
Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr Ser Tyr Asp His Gln Thr
225                 230                 235                 240 
Glu Glu Leu Asn Leu Trp Val Arg Gly Cys Arg Ala Ala Leu Leu Ser
                245                 250                 255     
Tyr Tyr Ser Ser Leu Met Asn Ser Met Gly Val Val Thr Leu Leu Ile
            260                 265                 270         
Trp Leu Phe Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr
        275                 280                 285             
Ser Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Glu
    290                 295                 300                 
Gly Trp Leu Leu Glu Lys Ser Val Pro Glu Thr Trp Lys Ala Phe Leu
305                 310                 315                 320 
Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly
                325                 330                 335     
Ala Gly Ala Gly Gln Ala Pro Glu Ala Gly
            340                 345     


<210> 9409
<211> 211
<212> PRT
<213> Homo sapiens

<400> 9409
Met Lys Asn Lys Arg Asn Val Thr Glu Phe Val Leu Thr Gly Leu Thr
 1               5                  10                  15      
Gln Asn Pro Lys Met Glu Lys Val Met Phe Ala Val Phe Leu Val Leu
            20                  25                  30          
Tyr Met Ile Thr Leu Ser Gly Asn Leu Leu Leu Val Val Thr Ile Thr
        35                  40                  45              
Thr Ser Gln Ala Leu Ser Ser Pro Met Tyr Phe Phe Leu Ser His Leu
    50                  55                  60                  
Ser Leu Ile Asp Thr Val Tyr Ser Ser Ser Ser Ala Pro Lys Leu Ile
65                  70                  75                  80  
Val Asp Ser Leu His Glu Lys Lys Ile Ile Ser Phe Asn Gly Cys Met
                85                  90                  95      
Ala Gln Ala Tyr Glu Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu
            100                 105                 110         
Leu Thr Val Met Ala Cys Asp Asn Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125             
His Tyr Thr Thr Ile Met Ser His Ser Leu Cys Ile Leu Leu Val Val
    130                 135                 140                 
Val Ala Trp Ile Gly Gly Phe Leu His Ala Asn Ile Gln Ile Leu Phe
145                 150                 155                 160 
Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met
                165                 170                 175     
Cys Asp Leu Cys Pro Leu Leu Lys Leu Val Cys Leu Asp Thr His Thr
            180                 185                 190         
Leu Gly Leu Phe Val Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn
        195                 200                 205             
Phe Leu Leu
    210     


<210> 9410
<211> 99
<212> PRT
<213> Homo sapiens

<400> 9410
Val Phe Gln Asp Leu Gly Met Glu Val Leu Ser Gly Val Ala Lys Gly
 1               5                  10                  15      
Tyr Asn Ile Cys Leu Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr
            20                  25                  30          
Tyr Thr Met Leu Gly Thr Pro Val Ser Ile Thr Met Ile Tyr Ile Pro
        35                  40                  45              
Asn Ala Thr Ala Ser Leu Asn Leu Ala Leu Ser Leu Leu Leu Phe Leu
    50                  55                  60                  
Glu Ile Tyr Asn Glu Arg Val Arg Asp Leu Leu Lys Gln Ser Gly Gln
65                  70                  75                  80  
Lys Lys Ser Tyr Thr Leu Arg Val Arg Glu His Pro Glu Met Gly Pro
                85                  90                  95      
Tyr Val Gln
            


<210> 9411
<211> 474
<212> PRT
<213> Homo sapiens

<400> 9411
Met Trp Thr Val Gln Asn Arg Glu Ser Leu Gly Leu Leu Ser Phe Pro
 1               5                  10                  15      
Val Met Ile Thr Met Val Cys Cys Ala His Ser Thr Asn Glu Pro Ser
            20                  25                  30          
Asn Met Ser Tyr Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr
        35                  40                  45              
Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Asp Val Gly
    50                  55                  60                  
Met Arg Ile Asp Val Ala Ser Ile Asp Met Val Ser Glu Val Asn Met
65                  70                  75                  80  
Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ser Trp Lys Asp Lys Arg
                85                  90                  95      
Leu Ser Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val
            100                 105                 110         
Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys
        115                 120                 125             
Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His
    130                 135                 140                 
Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala
145                 150                 155                 160 
Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr
                165                 170                 175     
Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr
            180                 185                 190         
Trp Asn Gly Gly Glu Gly Ala Val Thr Gly Val Asn Lys Ile Glu Leu
        195                 200                 205             
Pro Gln Phe Ser Ile Val Asp Tyr Lys Met Val Ser Lys Lys Val Glu
    210                 215                 220                 
Phe Thr Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys
225                 230                 235                 240 
Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Thr Leu
                245                 250                 255     
Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser
            260                 265                 270         
Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr
        275                 280                 285             
Ile Ser Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys
    290                 295                 300                 
Ala Ile Asp Ile Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala
305                 310                 315                 320 
Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Lys Gly Pro
                325                 330                 335     
Gln Lys Lys Gly Ala Ser Lys Gln Asp Gln Ser Ala Asn Glu Lys Asn
            340                 345                 350         
Lys Leu Glu Met Asn Lys Val Gln Val Asp Ala His Gly Asn Ile Leu
        355                 360                 365             
Leu Ser Thr Leu Glu Ile Arg Asn Glu Thr Ser Gly Ser Glu Val Leu
    370                 375                 380                 
Thr Ser Val Ser Asp Pro Lys Ala Thr Met Tyr Ser Tyr Asp Ser Ala
385                 390                 395                 400 
Ser Ile Gln Tyr Arg Lys Pro Leu Ser Ser Arg Glu Ala Tyr Gly Arg
                405                 410                 415     
Ala Leu Asp Arg His Gly Val Pro Ser Lys Gly Arg Ile Arg Arg Arg
            420                 425                 430         
Ala Ser Gln Leu Lys Val Lys Ile Pro Asp Leu Thr Asp Val Asn Ser
        435                 440                 445             
Ile Asp Lys Trp Ser Arg Met Phe Phe Pro Ile Thr Phe Ser Leu Phe
    450                 455                 460                 
Asn Val Val Tyr Trp Leu Tyr Tyr Val His
465                 470                 


<210> 9412
<211> 1149
<212> PRT
<213> Homo sapiens

<400> 9412
Met Pro Thr Met Arg Arg Thr Val Ser Glu Ile Arg Ser Arg Ala Glu
 1               5                  10                  15      
Gly Tyr Glu Lys Thr Asp Asp Val Ser Glu Lys Thr Ser Leu Ala Asp
            20                  25                  30          
Gln Glu Glu Val Arg Thr Ile Phe Ile Asn Gln Pro Gln Leu Thr Lys
        35                  40                  45              
Phe Cys Asn Asn His Val Ser Thr Ala Lys Tyr Asn Ile Ile Thr Phe
    50                  55                  60                  
Leu Pro Arg Phe Leu Tyr Ser Gln Phe Arg Arg Ala Ala Asn Ser Phe
65                  70                  75                  80  
Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val Ser Pro Thr
                85                  90                  95      
Gly Arg Tyr Thr Thr Leu Val Pro Leu Leu Phe Ile Leu Ala Val Ala
            100                 105                 110         
Ala Ile Lys Glu Ile Ile Glu Asp Ile Lys Arg His Lys Ala Asp Asn
        115                 120                 125             
Ala Val Asn Lys Lys Gln Thr Gln Val Leu Arg Asn Gly Ala Trp Glu
    130                 135                 140                 
Ile Val His Trp Glu Lys Val Ala Val Gly Glu Ile Val Lys Val Thr
145                 150                 155                 160 
Asn Gly Glu His Leu Pro Ala Asp Leu Ile Ser Leu Ser Ser Ser Glu
                165                 170                 175     
Pro Gln Ala Met Cys Tyr Ile Glu Thr Ser Asn Leu Asp Gly Glu Thr
            180                 185                 190         
Asn Leu Lys Ile Arg Gln Gly Leu Pro Ala Thr Ser Asp Ile Lys Asp
        195                 200                 205             
Val Asp Ser Leu Met Arg Ile Ser Gly Arg Ile Glu Cys Glu Ser Pro
    210                 215                 220                 
Asn Arg His Leu Tyr Asp Phe Val Gly Asn Ile Arg Leu Asp Gly His
225                 230                 235                 240 
Gly Thr Val Pro Leu Gly Ala Asp Gln Ile Leu Leu Arg Gly Ala Gln
                245                 250                 255     
Leu Arg Asn Thr Gln Trp Val His Gly Ile Val Val Tyr Thr Gly His
            260                 265                 270         
Asp Thr Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu Ser
        275                 280                 285             
Asn Val Glu Arg Ile Thr Asn Val Gln Ile Leu Ile Leu Phe Cys Ile
    290                 295                 300                 
Leu Ile Ala Met Ser Leu Val Cys Ser Val Gly Ser Ala Ile Trp Asn
305                 310                 315                 320 
Arg Arg His Ser Gly Lys Asp Trp Tyr Leu Asn Leu Asn Tyr Gly Gly
                325                 330                 335     
Ala Ser Asn Phe Gly Leu Asn Phe Leu Thr Phe Ile Ile Leu Phe Asn
            340                 345                 350         
Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val Val Lys Phe
        355                 360                 365             
Thr Gln Ala Tyr Phe Ile Asn Trp Asp Leu Asp Met His Tyr Glu Pro
    370                 375                 380                 
Thr Asp Thr Ala Ala Met Ala Arg Thr Ser Asn Leu Asn Glu Glu Leu
385                 390                 395                 400 
Gly Gln Val Lys Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Cys
                405                 410                 415     
Asn Val Met Gln Phe Lys Lys Cys Thr Ile Ala Gly Val Ala Tyr Gly
            420                 425                 430         
Gln Asn Ser Gln Phe Gly Asp Glu Lys Thr Phe Ser Asp Ser Ser Leu
        435                 440                 445             
Leu Glu Asn Leu Gln Asn Asn His Pro Thr Ala Pro Ile Ile Cys Glu
    450                 455                 460                 
Phe Leu Thr Met Met Ala Val Cys His Thr Ala Val Pro Glu Arg Glu
465                 470                 475                 480 
Gly Asp Lys Ile Ile Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu
                485                 490                 495     
Val Arg Ala Ala Lys Gln Leu Asn Phe Val Phe Thr Gly Arg Thr Pro
            500                 505                 510         
Asp Ser Val Ile Ile Asp Ser Leu Gly Gln Glu Glu Arg Tyr Glu Leu
        515                 520                 525             
Leu Asn Val Leu Glu Phe Thr Ser Ala Arg Lys Arg Met Ser Val Ile
    530                 535                 540                 
Val Arg Thr Pro Ser Gly Lys Leu Arg Leu Tyr Cys Lys Gly Ala Asp
545                 550                 555                 560 
Thr Val Ile Tyr Asp Arg Leu Ala Glu Thr Ser Lys Tyr Lys Glu Ile
                565                 570                 575     
Thr Leu Lys His Leu Glu Gln Phe Ala Thr Glu Gly Leu Arg Thr Leu
            580                 585                 590         
Cys Phe Ala Val Ala Glu Ile Ser Glu Ser Asp Phe Gln Glu Trp Arg
        595                 600                 605             
Ala Val Tyr Gln Arg Ala Ser Thr Ser Val Gln Asn Arg Leu Leu Lys
    610                 615                 620                 
Leu Glu Glu Ser Tyr Glu Leu Ile Glu Lys Asn Leu Gln Leu Leu Gly
625                 630                 635                 640 
Ala Thr Ala Ile Glu Asp Lys Leu Gln Asp Gln Val Pro Glu Thr Ile
                645                 650                 655     
Glu Thr Leu Met Lys Ala Asp Ile Lys Ile Trp Ile Leu Thr Gly Asp
            660                 665                 670         
Lys Gln Glu Thr Ala Ile Asn Ile Gly His Ser Cys Lys Leu Leu Lys
        675                 680                 685             
Lys Asn Met Gly Met Ile Val Ile Asn Glu Gly Ser Leu Asp Gly Thr
    690                 695                 700                 
Arg Glu Thr Leu Ser Arg His Cys Thr Thr Leu Gly Asp Ala Leu Arg
705                 710                 715                 720 
Lys Glu Asn Asp Phe Ala Leu Ile Ile Asp Gly Lys Thr Leu Lys Tyr
                725                 730                 735     
Ala Leu Thr Phe Gly Val Arg Gln Tyr Phe Leu Asp Leu Ala Leu Ser
            740                 745                 750         
Cys Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln Lys Ser Glu
        755                 760                 765             
Val Val Glu Met Val Lys Lys Gln Val Lys Val Val Thr Leu Ala Ile
    770                 775                 780                 
Gly Asp Gly Ala Asn Asp Val Ser Met Ile Gln Thr Ala His Val Gly
785                 790                 795                 800 
Val Gly Ile Ser Gly Asn Glu Gly Leu Gln Ala Ala Asn Ser Ser Asp
                805                 810                 815     
Tyr Ser Ile Ala Gln Phe Lys Tyr Leu Lys Asn Leu Leu Met Ile His
            820                 825                 830         
Gly Ala Trp Asn Tyr Asn Arg Val Ser Lys Cys Ile Leu Tyr Cys Phe
        835                 840                 845             
Tyr Lys Asn Ile Val Leu Tyr Ile Ile Glu Ile Trp Phe Ala Phe Val
    850                 855                 860                 
Asn Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys Ile Gly Leu
865                 870                 875                 880 
Tyr Asn Val Met Phe Thr Ala Met Pro Pro Leu Thr Leu Gly Ile Phe
                885                 890                 895     
Glu Arg Ser Cys Arg Lys Glu Asn Met Leu Lys Tyr Pro Glu Leu Tyr
            900                 905                 910         
Lys Thr Ser Gln Asn Ala Leu Asp Phe Asn Thr Lys Val Phe Trp Val
        915                 920                 925             
His Cys Leu Asn Gly Leu Phe His Ser Val Ile Leu Phe Trp Phe Pro
    930                 935                 940                 
Leu Lys Ala Leu Gln Tyr Gly Thr Ala Phe Gly Asn Gly Lys Thr Ser
945                 950                 955                 960 
Asp Tyr Leu Leu Leu Gly Asn Phe Val Tyr Thr Phe Val Val Ile Thr
                965                 970                 975     
Val Cys Leu Lys Ala Gly Leu Glu Thr Ser Tyr Trp Thr Trp Phe Ser
            980                 985                 990         
His Ile Ala Ile Trp Gly Ser Ile Ala Leu Trp Val Val Phe Phe Gly
        995                 1000                1005            
Ile Tyr Ser Ser Leu Trp Pro Ala Ile Pro Met Ala Pro Asp Met Ser
    1010                1015                1020                
Gly Glu Ala Ala Met Leu Phe Ser Ser Gly Val Phe Trp Met Gly Leu
1025                1030                1035                1040
Leu Phe Ile Pro Val Ala Ser Leu Leu Leu Asp Val Val Tyr Lys Val
                1045                1050                1055    
Ile Lys Arg Thr Ala Phe Lys Thr Leu Val Asp Glu Val Gln Glu Leu
            1060                1065                1070        
Glu Ala Lys Ser Gln Asp Pro Gly Ala Val Val Leu Gly Lys Ser Leu
        1075                1080                1085            
Thr Glu Arg Ala Gln Leu Leu Lys Asn Val Phe Lys Lys Asn His Val
    1090                1095                1100                
Asn Leu Tyr Arg Ser Glu Ser Leu Gln Gln Asn Leu Leu His Gly Tyr
1105                1110                1115                1120
Ala Phe Ser Gln Asp Glu Asn Gly Ile Val Ser Gln Ser Glu Val Ile
                1125                1130                1135    
Arg Ala Tyr Asp Thr Thr Lys Gln Arg Pro Asp Glu Trp
            1140                1145                


<210> 9413
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 9413
Met Pro Thr Met Arg Arg Thr Val Ser Glu Ile Arg Ser Arg Ala Glu
 1               5                  10                  15      
Gly Tyr Glu Lys Thr Asp Asp Val Ser Glu Lys Thr Ser Leu Ala Asp
            20                  25                  30          
Gln Glu Glu Val Arg Thr Ile Phe Ile Asn Gln Pro Gln Leu Thr Lys
        35                  40                  45              
Phe Cys Asn Asn His Val Ser Thr Ala Lys Tyr Asn Ile Ile Thr Phe
    50                  55                  60                  
Leu Pro Arg Phe Leu Tyr Ser Gln Phe Arg Arg Ala Ala Asn Ser Phe
65                  70                  75                  80  
Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val Ser Pro Thr
                85                  90                  95      
Gly Arg Tyr Thr Thr Leu Val Pro Leu Leu Phe Ile Leu Ala Val Ala
            100                 105                 110         
Ala Ile Lys Glu Ile Ile Glu Asp Ile Lys Arg His Lys Ala Asp Asn
        115                 120                 125             
Ala Val Asn Lys Lys Gln Thr Gln Val Leu Arg Asn Gly Ala Trp Glu
    130                 135                 140                 
Ile Val His Trp Glu Lys Val Ala Val Gly Glu Ile Val Lys Val Thr
145                 150                 155                 160 
Asn Gly Glu His Leu Pro Ala Asp Leu Ile Ser Leu Ser Ser Ser Glu
                165                 170                 175     
Pro Gln Ala Met Cys Tyr Ile Glu Thr Ser Asn Leu Asp Gly Glu Thr
            180                 185                 190         
Asn Leu Lys Ile Arg Gln Gly Leu Pro Ala Thr Ser Asp Ile Lys Asp
        195                 200                 205             
Val Asp Ser Leu Met Arg Ile Ser Gly Arg Ile Glu Cys Glu Ser Pro
    210                 215                 220                 
Asn Arg His Leu Tyr Asp Phe Val Gly Asn Ile Arg Leu Asp Gly His
225                 230                 235                 240 
Gly Thr Val Pro Leu Gly Ala Asp Gln Ile Leu Leu Arg Gly Ala Gln
                245                 250                 255     
Leu Arg Asn Thr Gln Trp Val His Gly Ile Val Val Tyr Thr Gly His
            260                 265                 270         
Asp Thr Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu Ser
        275                 280                 285             
Asn Val Glu Arg Ile Thr Asn Val Gln Ile Leu Ile Leu Phe Cys Ile
    290                 295                 300                 
Leu Ile Ala Met Ser Leu Val Cys Ser Val Gly Ser Ala Ile Trp Asn
305                 310                 315                 320 
Arg Arg His Ser Gly Lys Asp Trp Tyr Leu Asn Leu Asn Tyr Gly Gly
                325                 330                 335     
Ala Ser Asn Phe Gly Leu Asn Phe Leu Thr Phe Ile Ile Leu Phe Asn
            340                 345                 350         
Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val Val Lys Phe
        355                 360                 365             
Thr Gln Ala Tyr Phe Ile Asn Trp Asp Leu Asp Met His Tyr Glu Pro
    370                 375                 380                 
Thr Asp Thr Ala Ala Met Ala Arg Thr Ser Asn Leu Asn Glu Glu Leu
385                 390                 395                 400 
Gly Gln Val Lys Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Cys
                405                 410                 415     
Asn Val Met Gln Phe Lys Lys Cys Thr Ile Ala Gly Val Ala Tyr Gly
            420                 425                 430         
His Val Pro Glu Pro Glu Asp Tyr Gly Cys Ser Pro Asp Glu Trp Gln
        435                 440                 445             
Asn Ser Gln Phe Gly Asp Glu Lys Thr Phe Ser Asp Ser Ser Leu Leu
    450                 455                 460                 
Glu Asn Leu Gln Asn Asn His Pro Thr Ala Pro Ile Ile Cys Glu Phe
465                 470                 475                 480 
Leu Thr Met Met Ala Val Cys His Thr Ala Val Pro Glu Arg Glu Gly
                485                 490                 495     
Asp Lys Ile Ile Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu Val
            500                 505                 510         
Arg Ala Ala Lys Gln Leu Asn Phe Val Phe Thr Gly Arg Thr Pro Asp
        515                 520                 525             
Ser Val Ile Ile Asp Ser Leu Gly Gln Glu Glu Arg Tyr Glu Leu Leu
    530                 535                 540                 
Asn Val Leu Glu Phe Thr Ser Ala Arg Lys Arg Met Ser Val Ile Val
545                 550                 555                 560 
Arg Thr Pro Ser Gly Lys Leu Arg Leu Tyr Cys Lys Gly Ala Asp Thr
                565                 570                 575     
Val Ile Tyr Asp Arg Leu Ala Glu Thr Ser Lys Tyr Lys Glu Ile Thr
            580                 585                 590         
Leu Lys His Leu Glu Gln Phe Ala Thr Glu Gly Leu Arg Thr Leu Cys
        595                 600                 605             
Phe Ala Val Ala Glu Ile Ser Glu Ser Asp Phe Gln Glu Trp Arg Ala
    610                 615                 620                 
Val Tyr Gln Arg Ala Ser Thr Ser Val Gln Asn Arg Leu Leu Lys Leu
625                 630                 635                 640 
Glu Glu Ser Tyr Glu Leu Ile Glu Lys Asn Leu Gln Leu Leu Gly Ala
                645                 650                 655     
Thr Ala Ile Glu Asp Lys Leu Gln Asp Gln Val Pro Glu Thr Ile Glu
            660                 665                 670         
Thr Leu Met Lys Ala Asp Ile Lys Ile Trp Ile Leu Thr Gly Asp Lys
        675                 680                 685             
Gln Glu Thr Ala Ile Asn Ile Gly His Ser Cys Lys Leu Leu Lys Lys
    690                 695                 700                 
Asn Met Gly Met Ile Val Ile Asn Glu Gly Ser Leu Asp Gly Thr Arg
705                 710                 715                 720 
Glu Thr Leu Ser Arg His Cys Thr Thr Leu Gly Asp Ala Leu Arg Lys
                725                 730                 735     
Glu Asn Asp Phe Ala Leu Ile Ile Asp Gly Lys Thr Leu Lys Tyr Ala
            740                 745                 750         
Leu Thr Phe Gly Val Arg Gln Tyr Phe Leu Asp Leu Ala Leu Ser Cys
        755                 760                 765             
Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln Lys Ser Glu Val
    770                 775                 780                 
Val Glu Met Val Lys Lys Gln Val Lys Val Val Thr Leu Ala Ile Gly
785                 790                 795                 800 
Asp Gly Ala Asn Asp Val Ser Met Ile Gln Thr Ala His Val Gly Val
                805                 810                 815     
Gly Ile Ser Gly Asn Glu Gly Leu Gln Ala Ala Asn Ser Ser Asp Tyr
            820                 825                 830         
Ser Ile Ala Gln Phe Lys Tyr Leu Lys Asn Leu Leu Met Ile His Gly
        835                 840                 845             
Ala Trp Asn Tyr Asn Arg Val Ser Lys Cys Ile Leu Tyr Cys Phe Tyr
    850                 855                 860                 
Lys Asn Ile Val Leu Tyr Ile Ile Glu Ile Trp Phe Ala Phe Val Asn
865                 870                 875                 880 
Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys Ile Gly Leu Tyr
                885                 890                 895     
Asn Val Met Phe Thr Ala Met Pro Pro Leu Thr Leu Gly Ile Phe Glu
            900                 905                 910         
Arg Ser Cys Arg Lys Glu Asn Met Leu Lys Tyr Pro Glu Leu Tyr Lys
        915                 920                 925             
Thr Ser Gln Asn Ala Leu Asp Phe Asn Thr Lys Val Phe Trp Val His
    930                 935                 940                 
Cys Leu Asn Gly Leu Phe His Ser Val Ile Leu Phe Trp Phe Pro Leu
945                 950                 955                 960 
Lys Ala Leu Gln Tyr Gly Thr Ala Phe Gly Asn Gly Lys Thr Ser Asp
                965                 970                 975     
Tyr Leu Leu Leu Gly Asn Phe Val Tyr Thr Phe Val Val Ile Thr Val
            980                 985                 990         
Cys Leu Lys Ala Gly Leu Glu Thr Ser Tyr Trp Thr Trp Phe Ser His
        995                 1000                1005            
Ile Ala Ile Trp Gly Ser Ile Ala Leu Trp Val Val Phe Phe Gly Ile
    1010                1015                1020                
Tyr Ser Ser Leu Trp Pro Ala Ile Pro Met Ala Pro Asp Met Ser Gly
1025                1030                1035                1040
Glu Ala Ala Met Leu Phe Ser Ser Gly Val Phe Trp Met Gly Leu Leu
                1045                1050                1055    
Phe Ile Pro Val Ala Ser Leu Leu Leu Asp Val Val Tyr Lys Val Ile
            1060                1065                1070        
Lys Arg Thr Ala Phe Lys Thr Leu Val Asp Glu Val Gln Glu Leu Glu
        1075                1080                1085            
Ala Lys Ser Gln Asp Pro Gly Ala Val Val Leu Gly Lys Ser Leu Thr
    1090                1095                1100                
Glu Arg Ala Gln Leu Leu Lys Asn Val Phe Lys Lys Asn His Val Asn
1105                1110                1115                1120
Leu Tyr Arg Ser Glu Ser Leu Gln Gln Asn Leu Leu His Gly Tyr Ala
                1125                1130                1135    
Phe Ser Gln Asp Glu Asn Gly Ile Val Ser Gln Ser Glu Val Ile Arg
            1140                1145                1150        
Ala Tyr Asp Thr Thr Lys Gln Arg Pro Asp Glu Trp
        1155                1160                


<210> 9414
<211> 270
<212> PRT
<213> Homo sapiens

<400> 9414
Ser Val Arg Ala Arg Pro Pro Pro Pro Gly Ser Pro Glu Gln Pro Gly
 1               5                  10                  15      
Ala Arg Pro Arg Trp Ala Gln His Ser Val Gly Gly Gly Gly Gly Ala
            20                  25                  30          
Met Leu Cys Phe Leu Arg Gly Met Ala Phe Val Pro Phe Leu Leu Val
        35                  40                  45              
Thr Trp Ser Ser Ala Ala Phe Ile Ile Ser Tyr Val Val Ala Val Leu
    50                  55                  60                  
Ser Gly His Val Asn Pro Phe Leu Pro Phe Ala Ser Asp Thr Gly Thr
65                  70                  75                  80  
Thr Pro Pro Glu Ser Gly Ile Phe Gly Phe Met Ile Asn Phe Ser Ala
                85                  90                  95      
Phe Leu Gly Ala Ala Thr Met Tyr Thr Arg Tyr Lys Ile Val Gln Lys
            100                 105                 110         
Gln Asn Gln Thr Cys Tyr Phe Ser Thr Pro Val Phe Asn Leu Val Ser
        115                 120                 125             
Leu Val Leu Gly Leu Val Gly Cys Phe Gly Met Gly Ile Val Ala Asn
    130                 135                 140                 
Phe Gln Glu Leu Ala Val Pro Val Val His Asp Gly Gly Ala Leu Leu
145                 150                 155                 160 
Ala Phe Val Cys Gly Val Val Tyr Thr Leu Leu Gln Ser Ile Ile Ser
                165                 170                 175     
Tyr Lys Ser Cys Pro Gln Trp Asn Ser Leu Ser Thr Cys His Ile Arg
            180                 185                 190         
Met Val Ile Ser Ala Val Ser Cys Ala Ala Val Ile Pro Met Ile Val
        195                 200                 205             
Cys Ala Ser Leu Ile Ser Ile Thr Lys Leu Glu Trp Asn Pro Arg Glu
    210                 215                 220                 
Lys Asp Tyr Val Tyr His Val Val Ser Ala Ile Cys Glu Trp Thr Val
225                 230                 235                 240 
Ala Phe Gly Phe Ile Phe Tyr Phe Leu Thr Phe Ile Gln Asp Phe Gln
                245                 250                 255     
Ser Val Thr Leu Arg Ile Ser Thr Glu Ile Asn Gly Asp Ile
            260                 265                 270 


<210> 9415
<211> 307
<212> PRT
<213> Homo sapiens

<400> 9415
Met Leu Asn Phe Thr Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr
 1               5                  10                  15      
Ser Arg Arg Glu Trp Gln Val Leu Phe Phe Ile Ile Phe Leu Val Val
            20                  25                  30          
Tyr Ile Ile Thr Met Val Gly Asn Ile Gly Met Met Val Leu Ile Lys
        35                  40                  45              
Val Ser Pro Gln Leu Asn Asn Pro Met Tyr Phe Phe Leu Ser His Leu
    50                  55                  60                  
Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu
65                  70                  75                  80  
Glu Asn Leu Phe Ser Asp Lys Lys Thr Ile Thr Tyr Ala Gly Cys Leu
                85                  90                  95      
Val Gln Cys Phe Phe Phe Ile Ala Leu Val His Val Glu Ile Phe Ile
            100                 105                 110         
Leu Ala Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Asn Pro Leu
        115                 120                 125             
Leu Tyr Gly Ser Lys Met Ser Arg Val Val Cys Ile Arg Leu Ile Thr
    130                 135                 140                 
Phe Pro Tyr Ile Tyr Gly Phe Leu Thr Ser Leu Ala Ala Thr Leu Trp
145                 150                 155                 160 
Thr Tyr Gly Leu Tyr Phe Cys Gly Lys Ile Glu Ile Asn His Phe Tyr
                165                 170                 175     
Cys Ala Asp Pro Pro Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Val
            180                 185                 190         
Lys Glu Tyr Thr Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser
        195                 200                 205             
Leu Thr Val Ile Ile Ile Ser Tyr Leu Phe Ile Leu Ile Ala Ile Leu
    210                 215                 220                 
Arg Met Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly
225                 230                 235                 240 
Ser His Leu Thr Ala Val Ile Ile Phe Tyr Gly Thr Leu Ile Phe Met
                245                 250                 255     
Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val
            260                 265                 270         
Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr
        275                 280                 285             
Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Met Met Lys Val Ile Ser
    290                 295                 300                 
Arg Ser Cys
305         


<210> 9416
<211> 2237
<212> PRT
<213> Homo sapiens

<400> 9416
Met Val Arg Phe Gly Asp Glu Leu Gly Gly Arg Tyr Gly Gly Pro Gly
 1               5                  10                  15      
Gly Gly Glu Arg Ala Arg Gly Gly Gly Ala Gly Gly Ala Gly Gly Pro
            20                  25                  30          
Gly Pro Gly Gly Leu Gln Pro Gly Gln Arg Val Leu Tyr Lys Gln Ser
        35                  40                  45              
Ile Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro Ile Pro Val
    50                  55                  60                  
Lys Gln Asn Cys Phe Thr Val Asn Arg Ser Leu Phe Val Phe Ser Glu
65                  70                  75                  80  
Asp Asn Val Val Arg Lys Tyr Ala Lys Arg Ile Thr Glu Trp Pro Pro
                85                  90                  95      
Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys Ile Val Leu
            100                 105                 110         
Ala Leu Glu Gln His Leu Pro Asp Gly Asp Lys Thr Pro Met Ser Glu
        115                 120                 125             
Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu
    130                 135                 140                 
Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Val Phe His Lys Gly Ser
145                 150                 155                 160 
Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val Val Leu Thr
                165                 170                 175     
Gly Ile Leu Ala Thr Ala Gly Thr Asp Phe Asp Leu Arg Thr Leu Arg
            180                 185                 190         
Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser
        195                 200                 205             
Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu
    210                 215                 220                 
Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile
225                 230                 235                 240 
Gly Leu Glu Phe Tyr Met Gly Lys Phe His Lys Ala Cys Phe Pro Asn
                245                 250                 255     
Ser Thr Asp Ala Glu Pro Val Gly Asp Phe Pro Cys Gly Lys Glu Ala
            260                 265                 270         
Pro Ala Arg Leu Cys Glu Gly Asp Thr Glu Cys Arg Glu Tyr Trp Pro
        275                 280                 285             
Gly Pro Asn Phe Gly Ile Thr Asn Phe Asp Asn Ile Leu Phe Ala Ile
    290                 295                 300                 
Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Ile Leu
305                 310                 315                 320 
Tyr Asn Thr Asn Asp Ala Ala Gly Asn Thr Trp Asn Trp Leu Tyr Phe
                325                 330                 335     
Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu Asn Leu Val Leu
            340                 345                 350         
Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn
        355                 360                 365             
Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu
    370                 375                 380                 
Leu Asn Gly Tyr Leu Glu Trp Ile Phe Lys Ala Glu Glu Val Met Leu
385                 390                 395                 400 
Ala Glu Glu Asp Arg Asn Ala Glu Glu Lys Ser Pro Leu Asp Val Leu
                405                 410                 415     
Lys Arg Ala Ala Thr Lys Lys Ser Arg Asn Asp Leu Ile His Ala Glu
            420                 425                 430         
Glu Gly Glu Asp Arg Phe Ala Asp Leu Cys Ala Val Gly Ser Pro Phe
        435                 440                 445             
Ala Arg Ala Ser Leu Lys Ser Gly Lys Thr Glu Ser Ser Ser Tyr Phe
    450                 455                 460                 
Arg Arg Lys Glu Lys Met Phe Arg Phe Phe Ile Arg Arg Met Val Lys
465                 470                 475                 480 
Ala Gln Ser Phe Tyr Trp Val Val Leu Cys Val Val Ala Leu Asn Thr
                485                 490                 495     
Leu Cys Val Ala Met Val His Tyr Asn Gln Pro Arg Arg Leu Thr Thr
            500                 505                 510         
Thr Leu Tyr Phe Ala Glu Phe Val Phe Leu Gly Leu Phe Leu Thr Glu
        515                 520                 525             
Met Ser Leu Lys Met Tyr Gly Leu Gly Pro Arg Ser Tyr Phe Arg Ser
    530                 535                 540                 
Ser Phe Asn Cys Phe Asp Phe Gly Val Ile Val Gly Ser Val Phe Glu
545                 550                 555                 560 
Val Val Trp Ala Ala Ile Lys Pro Gly Ser Ser Phe Gly Ile Ser Val
                565                 570                 575     
Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val Thr Lys Tyr Trp
            580                 585                 590         
Ser Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn Ser Met Lys Ser
        595                 600                 605             
Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile Val Val Phe Ala
    610                 615                 620                 
Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn Phe Gln Asp Glu
625                 630                 635                 640 
Thr Pro Thr Thr Asn Phe Asp Thr Phe Pro Ala Ala Ile Leu Thr Val
                645                 650                 655     
Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr His Gly
            660                 665                 670         
Ile Glu Ser Gln Gly Gly Val Ser Lys Gly Met Phe Ser Ser Phe Tyr
        675                 680                 685             
Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe
    690                 695                 700                 
Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys
705                 710                 715                 720 
Asp Glu Glu Glu Met Glu Glu Ala Ala Asn Gln Lys Leu Ala Leu Gln
                725                 730                 735     
Lys Ala Lys Glu Val Ala Glu Val Ser Pro Met Ser Ala Ala Asn Ile
            740                 745                 750         
Ser Ile Ala Ala Arg Gln Gln Asn Ser Ala Lys Ala Arg Ser Val Trp
        755                 760                 765             
Glu Gln Arg Ala Ser Gln Leu Arg Leu Gln Asn Leu Arg Ala Ser Cys
    770                 775                 780                 
Glu Ala Leu Tyr Ser Glu Met Asp Pro Glu Glu Arg Leu Arg Phe Ala
785                 790                 795                 800 
Thr Thr Arg His Leu Arg Pro Asp Met Lys Thr His Leu Asp Arg Pro
                805                 810                 815     
Leu Val Val Glu Leu Gly Arg Asp Gly Ala Arg Gly Pro Val Gly Gly
            820                 825                 830         
Lys Ala Arg Pro Glu Ala Ala Glu Ala Pro Glu Gly Val Asp Pro Pro
        835                 840                 845             
Arg Arg His His Arg His Arg Asp Lys Asp Lys Thr Pro Ala Ala Gly
    850                 855                 860                 
Asp Gln Asp Arg Ala Glu Ala Pro Lys Ala Glu Ser Gly Glu Pro Gly
865                 870                 875                 880 
Ala Arg Glu Glu Arg Pro Arg Pro His Arg Ser His Ser Lys Glu Ala
                885                 890                 895     
Ala Gly Pro Pro Glu Ala Arg Ser Glu Arg Gly Arg Gly Pro Gly Pro
            900                 905                 910         
Glu Gly Gly Arg Arg His His Arg Arg Gly Ser Pro Glu Glu Ala Ala
        915                 920                 925             
Glu Arg Glu Pro Arg Arg His Arg Ala His Arg His Gln Asp Pro Ser
    930                 935                 940                 
Lys Glu Cys Ala Gly Ala Lys Gly Glu Arg Arg Ala Arg His Arg Gly
945                 950                 955                 960 
Gly Pro Arg Ala Gly Pro Arg Glu Ala Glu Ser Gly Glu Glu Pro Ala
                965                 970                 975     
Arg Arg His Arg Ala Arg His Lys Ala Gln Pro Ala His Glu Ala Val
            980                 985                 990         
Glu Lys Glu Thr Thr Glu Lys Glu Ala Thr Glu Lys Glu Ala Glu Ile
        995                 1000                1005            
Val Glu Ala Asp Lys Glu Lys Glu Leu Arg Asn His Gln Pro Arg Glu
    1010                1015                1020                
Pro His Cys Asp Leu Glu Thr Ser Gly Thr Val Thr Val Gly Pro Met
1025                1030                1035                1040
His Thr Leu Pro Ser Thr Cys Leu Gln Lys Val Glu Glu Gln Pro Glu
                1045                1050                1055    
Asp Ala Asp Asn Gln Arg Asn Val Thr Arg Met Gly Ser Gln Pro Pro
            1060                1065                1070        
Asp Pro Asn Thr Ile Val His Ile Pro Val Met Leu Thr Gly Pro Leu
        1075                1080                1085            
Gly Glu Ala Thr Val Val Pro Ser Gly Asn Val Asp Leu Glu Ser Gln
    1090                1095                1100                
Ala Glu Gly Lys Lys Glu Val Glu Ala Asp Asp Val Met Arg Ser Gly
1105                1110                1115                1120
Pro Arg Pro Ile Val Pro Tyr Ser Ser Met Phe Cys Leu Ser Pro Thr
                1125                1130                1135    
Asn Leu Leu Arg Arg Phe Cys His Tyr Ile Val Thr Met Arg Tyr Phe
            1140                1145                1150        
Glu Val Val Ile Leu Val Val Ile Ala Leu Ser Ser Ile Ala Leu Ala
        1155                1160                1165            
Ala Glu Asp Pro Val Arg Thr Asp Ser Pro Arg Asn Asn Ala Leu Lys
    1170                1175                1180                
Tyr Leu Asp Tyr Ile Phe Thr Gly Val Phe Thr Phe Glu Met Val Ile
1185                1190                1195                1200
Lys Met Ile Asp Leu Gly Leu Leu Leu His Pro Gly Ala Tyr Phe Arg
                1205                1210                1215    
Asp Leu Trp Asn Ile Leu Asp Phe Ile Val Val Ser Gly Ala Leu Val
            1220                1225                1230        
Ala Phe Ala Phe Ser Gly Ser Lys Gly Lys Asp Ile Asn Thr Ile Lys
        1235                1240                1245            
Ser Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg
    1250                1255                1260                
Leu Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val Asn Ser Leu Lys
1265                1270                1275                1280
Asn Val Leu Asn Ile Leu Ile Val Tyr Met Leu Phe Met Phe Ile Phe
                1285                1290                1295    
Ala Val Ile Ala Val Gln Leu Phe Lys Gly Lys Phe Phe Tyr Cys Thr
            1300                1305                1310        
Asp Glu Ser Lys Glu Leu Glu Arg Asp Cys Arg Gly Gln Tyr Leu Asp
        1315                1320                1325            
Tyr Glu Lys Glu Glu Val Glu Ala Gln Pro Arg Gln Trp Lys Lys Tyr
    1330                1335                1340                
Asp Phe His Tyr Asp Asn Val Leu Trp Ala Leu Leu Thr Leu Phe Thr
1345                1350                1355                1360
Val Ser Thr Gly Glu Gly Trp Pro Met Val Leu Lys His Ser Val Asp
                1365                1370                1375    
Ala Thr Tyr Glu Glu Gln Gly Pro Ser Pro Gly Tyr Arg Met Glu Leu
            1380                1385                1390        
Ser Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro Phe Phe Phe Val
        1395                1400                1405            
Asn Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln Glu Gln Gly Asp
    1410                1415                1420                
Lys Val Met Ser Glu Cys Ser Leu Glu Lys Asn Glu Arg Ala Cys Ile
1425                1430                1435                1440
Asp Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg Tyr Met Pro Gln Asn
                1445                1450                1455    
Arg Gln Ser Phe Gln Tyr Lys Thr Trp Thr Phe Val Val Ser Pro Pro
            1460                1465                1470        
Phe Glu Tyr Phe Ile Met Ala Met Ile Ala Leu Asn Thr Val Val Leu
        1475                1480                1485            
Met Met Lys Phe Tyr Asp Ala Pro Tyr Glu Tyr Glu Leu Met Leu Lys
    1490                1495                1500                
Cys Leu Asn Ile Val Phe Thr Ser Met Phe Ser Met Glu Cys Val Leu
1505                1510                1515                1520
Lys Ile Ile Ala Phe Gly Val Leu Asn Tyr Phe Arg Asp Ala Trp Asn
                1525                1530                1535    
Val Phe Asp Phe Val Thr Val Leu Gly Ser Ile Thr Asp Ile Leu Val
            1540                1545                1550        
Thr Glu Ile Ala Glu Thr Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg
        1555                1560                1565            
Leu Phe Arg Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Thr
    1570                1575                1580                
Ile Arg Ile Leu Leu Trp Thr Phe Val Gln Ser Phe Lys Ala Leu Pro
1585                1590                1595                1600
Tyr Val Cys Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile
                1605                1610                1615    
Gly Met Gln Val Phe Gly Asn Ile Ala Leu Asp Asp Asp Thr Ser Ile
            1620                1625                1630        
Asn Arg His Asn Asn Phe Arg Thr Phe Leu Gln Ala Leu Met Leu Leu
        1635                1640                1645            
Phe Arg Ser Ala Thr Gly Glu Ala Trp His Glu Ile Met Leu Ser Cys
    1650                1655                1660                
Leu Ser Asn Gln Ala Cys Asp Glu Gln Ala Asn Ala Thr Glu Cys Gly
1665                1670                1675                1680
Ser Asp Phe Ala Tyr Phe Tyr Phe Val Ser Phe Ile Phe Leu Cys Ser
                1685                1690                1695    
Phe Leu Met Leu Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Glu
            1700                1705                1710        
Tyr Leu Thr Arg Asp Ser Ser Ile Leu Gly Pro His His Leu Asp Glu
        1715                1720                1725            
Phe Ile Arg Val Trp Ala Glu Tyr Asp Pro Ala Ala Cys Gly Arg Ile
    1730                1735                1740                
Ser Tyr Asn Asp Met Phe Glu Met Leu Lys His Met Ser Pro Pro Leu
1745                1750                1755                1760
Gly Leu Gly Lys Lys Cys Pro Ala Arg Val Ala Tyr Lys Arg Leu Val
                1765                1770                1775    
Arg Met Asn Met Pro Ile Ser Asn Glu Asp Met Thr Val His Phe Thr
            1780                1785                1790        
Ser Thr Leu Met Ala Leu Ile Arg Thr Ala Leu Glu Ile Lys Leu Ala
        1795                1800                1805            
Pro Ala Gly Thr Lys Gln His Gln Cys Asp Ala Glu Leu Arg Lys Glu
    1810                1815                1820                
Ile Ser Val Val Trp Ala Asn Leu Pro Gln Lys Thr Leu Asp Leu Leu
1825                1830                1835                1840
Val Pro Pro His Lys Pro Asp Glu Met Thr Val Gly Lys Val Tyr Ala
                1845                1850                1855    
Ala Leu Met Ile Phe Asp Phe Tyr Lys Gln Asn Lys Thr Thr Arg Asp
            1860                1865                1870        
Gln Met Gln Gln Ala Pro Gly Gly Leu Ser Gln Met Gly Pro Val Ser
        1875                1880                1885            
Leu Phe His Pro Leu Lys Ala Thr Leu Glu Gln Thr Gln Pro Ala Val
    1890                1895                1900                
Leu Arg Gly Ala Arg Val Phe Leu Arg Gln Lys Ser Ser Thr Ser Leu
1905                1910                1915                1920
Ser Asn Gly Gly Ala Ile Gln Asn Gln Glu Ser Gly Ile Lys Glu Ser
                1925                1930                1935    
Val Ser Trp Gly Thr Gln Arg Thr Gln Asp Ala Pro His Glu Ala Arg
            1940                1945                1950        
Pro Pro Leu Glu Arg Gly His Ser Thr Glu Ile Pro Val Gly Arg Ser
        1955                1960                1965            
Gly Ala Leu Ala Val Asp Val Gln Met Gln Ser Ile Thr Arg Arg Gly
    1970                1975                1980                
Pro Asp Gly Glu Pro Gln Pro Gly Leu Glu Ser Gln Gly Arg Ala Ala
1985                1990                1995                2000
Ser Met Pro Arg Leu Ala Ala Glu Thr Gln Pro Val Thr Asp Ala Ser
                2005                2010                2015    
Pro Met Lys Arg Ser Ile Ser Thr Leu Ala Gln Arg Pro Arg Gly Thr
            2020                2025                2030        
His Leu Cys Ser Thr Thr Pro Asp Arg Pro Pro Pro Ser Gln Ala Ser
        2035                2040                2045            
Ser His His His His His Arg Cys His Arg Arg Arg Asp Arg Lys Gln
    2050                2055                2060                
Arg Ser Leu Glu Lys Gly Pro Ser Leu Ser Ala Asp Met Asp Gly Ala
2065                2070                2075                2080
Pro Ser Ser Ala Val Gly Pro Gly Leu Pro Pro Gly Glu Gly Pro Thr
                2085                2090                2095    
Gly Cys Arg Arg Glu Arg Glu Arg Arg Gln Glu Arg Gly Arg Ser Gln
            2100                2105                2110        
Glu Arg Arg Gln Pro Ser Ser Ser Ser Ser Glu Lys Gln Arg Phe Tyr
        2115                2120                2125            
Ser Cys Asp Arg Phe Gly Gly Arg Glu Pro Pro Lys Pro Lys Pro Ser
    2130                2135                2140                
Leu Ser Ser His Pro Thr Ser Pro Thr Ala Gly Gln Glu Pro Gly Pro
2145                2150                2155                2160
His Pro Gln Ala Gly Ser Ala Val Gly Phe Pro Asn Thr Thr Pro Cys
                2165                2170                2175    
Cys Arg Glu Thr Pro Ser Ala Ser Pro Trp Pro Leu Ala Leu Glu Leu
            2180                2185                2190        
Ala Leu Thr Leu Thr Trp Gly Ser Val Trp Thr Val Arg Pro Leu Ser
        2195                2200                2205            
Thr Pro Cys Leu Arg Thr Arg Ser Leu Ser Arg Arg Leu Trp Pro Pro
    2210                2215                2220                
Thr Arg Ala Ala Pro Pro Gly Leu Pro Thr Cys Pro Pro
2225                2230                2235        


<210> 9417
<211> 1083
<212> PRT
<213> Homo sapiens

<400> 9417
Met Pro Ala Met Arg Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp
 1               5                  10                  15      
Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Val Leu Gly
            20                  25                  30          
Asn Ala Gln Val Ala Gly Leu Phe Pro Val Val Tyr Cys Ser Asp Gly
        35                  40                  45              
Phe Cys Asp Leu Thr Gly Phe Ser Arg Ala Glu Val Met Gln Arg Gly
    50                  55                  60                  
Cys Ala Cys Ser Phe Leu Tyr Gly Pro Asp Thr Ser Glu Leu Val Arg
65                  70                  75                  80  
Gln Gln Ile Arg Lys Ala Leu Asp Glu His Lys Glu Phe Lys Ala Glu
                85                  90                  95      
Leu Ile Leu Tyr Arg Lys Ser Gly Leu Pro Phe Trp Cys Leu Leu Asp
            100                 105                 110         
Val Ile Pro Ile Lys Asn Glu Lys Gly Glu Val Ala Leu Phe Leu Val
        115                 120                 125             
Ser His Lys Asp Ile Ser Glu Thr Lys Asn Arg Gly Gly Pro Asp Arg
    130                 135                 140                 
Trp Lys Glu Thr Gly Gly Gly Arg Arg Arg Tyr Gly Arg Ala Arg Ser
145                 150                 155                 160 
Lys Gly Phe Asn Ala Asn Arg Arg Arg Ser Arg Ala Val Leu Tyr His
                165                 170                 175     
Leu Ser Gly His Leu Gln Lys Gln Pro Lys Gly Lys His Lys Leu Asn
            180                 185                 190         
Lys Gly Val Phe Gly Glu Lys Pro Asn Leu Pro Glu Tyr Lys Val Ala
        195                 200                 205             
Ala Ile Arg Lys Ser Pro Phe Ile Leu Leu His Cys Gly Ala Leu Arg
    210                 215                 220                 
Ala Thr Trp Asp Gly Phe Ile Leu Leu Ala Thr Leu Tyr Val Ala Val
225                 230                 235                 240 
Thr Val Pro Tyr Ser Val Cys Val Ser Thr Ala Arg Glu Pro Ser Ala
                245                 250                 255     
Ala Arg Gly Pro Pro Ser Val Cys Asp Leu Ala Val Glu Val Leu Phe
            260                 265                 270         
Ile Leu Asp Ile Val Leu Asn Phe Arg Thr Thr Phe Val Ser Lys Ser
        275                 280                 285             
Gly Gln Val Val Phe Ala Pro Lys Ser Ile Cys Leu His Tyr Val Thr
    290                 295                 300                 
Thr Trp Phe Leu Leu Asp Val Ile Ala Ala Leu Pro Phe Asp Leu Leu
305                 310                 315                 320 
His Ala Phe Lys Val Asn Val Tyr Phe Gly Ala His Leu Leu Lys Thr
                325                 330                 335     
Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Pro Arg Leu Asp Arg Tyr
            340                 345                 350         
Ser Gln Tyr Ser Ala Val Val Leu Thr Leu Leu Met Ala Val Phe Ala
        355                 360                 365             
Leu Leu Ala His Trp Val Ala Cys Val Trp Phe Tyr Ile Gly Gln Arg
    370                 375                 380                 
Glu Ile Glu Ser Ser Glu Ser Glu Leu Pro Glu Ile Gly Trp Leu Gln
385                 390                 395                 400 
Glu Leu Ala Arg Arg Leu Glu Thr Pro Tyr Tyr Leu Val Gly Arg Arg
                405                 410                 415     
Pro Ala Gly Gly Asn Ser Ser Gly Gln Ser Asp Asn Cys Ser Ser Ser
            420                 425                 430         
Ser Glu Ala Asn Gly Thr Gly Leu Glu Leu Leu Gly Gly Pro Ser Leu
        435                 440                 445             
Arg Ser Ala Tyr Ile Thr Ser Leu Tyr Phe Ala Leu Ser Ser Leu Thr
    450                 455                 460                 
Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Thr Glu Lys Ile
465                 470                 475                 480 
Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Val Val
                485                 490                 495     
Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ala Arg Arg Phe
            500                 505                 510         
Leu Tyr His Ser Arg Thr Arg Asp Leu Arg Asp Tyr Ile Arg Ile His
        515                 520                 525             
Arg Ile Pro Lys Pro Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln Ala
    530                 535                 540                 
Thr Trp Ala Val Asn Asn Gly Ile Asp Thr Thr Glu Leu Leu Gln Ser
545                 550                 555                 560 
Leu Pro Asp Glu Leu Arg Ala Asp Ile Ala Met His Leu His Lys Glu
                565                 570                 575     
Val Leu Gln Leu Pro Leu Phe Glu Ala Ala Ser Arg Gly Cys Leu Arg
            580                 585                 590         
Ala Leu Ser Leu Ala Leu Arg Pro Ala Phe Cys Thr Pro Gly Glu Tyr
        595                 600                 605             
Leu Ile His Gln Gly Asp Ala Leu Gln Ala Leu Tyr Phe Val Cys Ser
    610                 615                 620                 
Gly Ser Met Glu Val Leu Lys Gly Gly Thr Val Leu Ala Ile Leu Gly
625                 630                 635                 640 
Lys Gly Asp Leu Ile Gly Cys Glu Leu Pro Arg Arg Glu Gln Val Val
                645                 650                 655     
Lys Ala Asn Ala Asp Val Lys Gly Leu Thr Tyr Cys Val Leu Gln Cys
            660                 665                 670         
Leu Gln Leu Ala Gly Leu His Asp Ser Leu Ala Leu Tyr Pro Glu Phe
        675                 680                 685             
Ala Pro Arg Phe Ser Arg Gly Leu Arg Gly Glu Leu Ser Tyr Asn Leu
    690                 695                 700                 
Gly Ala Gly Gly Gly Ser Ala Glu Val Asp Thr Ser Ser Leu Ser Gly
705                 710                 715                 720 
Asp Asn Thr Leu Met Ser Thr Leu Glu Glu Lys Glu Thr Asp Gly Glu
                725                 730                 735     
Gln Gly Pro Thr Val Ser Pro Ala Pro Ala Asp Glu Pro Ser Ser Pro
            740                 745                 750         
Leu Leu Ser Pro Gly Cys Thr Ser Ser Ser Ser Ala Ala Lys Leu Leu
        755                 760                 765             
Ser Pro Arg Arg Thr Ala Pro Arg Pro Arg Leu Gly Gly Arg Gly Arg
    770                 775                 780                 
Pro Gly Arg Ala Gly Ala Leu Lys Ala Glu Ala Gly Pro Ser Ala Pro
785                 790                 795                 800 
Pro Arg Ala Leu Glu Gly Leu Arg Leu Pro Pro Met Pro Trp Asn Val
                805                 810                 815     
Pro Pro Asp Leu Ser Pro Arg Val Val Asp Gly Ile Glu Asp Gly Cys
            820                 825                 830         
Gly Ser Asp Gln Pro Lys Phe Ser Phe Arg Val Gly Gln Ser Gly Pro
        835                 840                 845             
Glu Cys Ser Ser Ser Pro Ser Pro Gly Pro Glu Ser Gly Leu Leu Thr
    850                 855                 860                 
Val Pro His Gly Pro Ser Glu Ala Arg Asn Thr Asp Thr Leu Asp Lys
865                 870                 875                 880 
Leu Arg Gln Ala Val Thr Glu Leu Ser Glu Gln Val Leu Gln Met Arg
                885                 890                 895     
Glu Gly Leu Gln Ser Leu Arg Gln Ala Val Gln Leu Val Leu Ala Pro
            900                 905                 910         
His Arg Glu Gly Pro Cys Pro Arg Ala Ser Gly Glu Gly Pro Cys Pro
        915                 920                 925             
Ala Ser Thr Ser Gly Leu Leu Gln Pro Leu Cys Val Asp Thr Gly Ala
    930                 935                 940                 
Ser Ser Tyr Cys Leu Gln Pro Pro Ala Gly Ser Val Leu Ser Gly Thr
945                 950                 955                 960 
Trp Pro His Pro Arg Pro Gly Pro Pro Pro Leu Met Ala Pro Trp Pro
                965                 970                 975     
Trp Gly Pro Pro Ala Ser Gln Ser Ser Pro Trp Pro Arg Ala Thr Ala
            980                 985                 990         
Phe Trp Thr Ser Thr Ser Asp Ser Glu Pro Pro Ala Ser Gly Asp Leu
        995                 1000                1005            
Cys Ser Glu Pro Ser Thr Pro Ala Ser Pro Pro Pro Ser Glu Glu Gly
    1010                1015                1020                
Ala Arg Thr Gly Pro Ala Glu Pro Val Ser Gln Ala Glu Ala Thr Ser
1025                1030                1035                1040
Thr Gly Glu Pro Pro Pro Gly Ser Gly Gly Leu Ala Leu Pro Trp Asp
                1045                1050                1055    
Pro His Ser Leu Glu Met Val Leu Ile Gly Cys His Gly Ser Gly Thr
            1060                1065                1070        
Val Gln Trp Thr Gln Glu Glu Gly Thr Gly Val
        1075                1080            


<210> 9418
<211> 1017
<212> PRT
<213> Homo sapiens

<400> 9418
Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp
 1               5                  10                  15      
Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Leu Leu Ala
            20                  25                  30          
Asn Ala Gln Gly Thr Arg Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly
        35                  40                  45              
Phe Cys Glu Leu Thr Gly Tyr Gly Arg Thr Glu Val Met Gln Lys Thr
    50                  55                  60                  
Cys Ser Cys Arg Phe Leu Tyr Gly Pro Glu Thr Ser Glu Pro Ala Leu
65                  70                  75                  80  
Gln Arg Leu His Lys Ala Leu Glu Gly His Gln Glu His Arg Ala Glu
                85                  90                  95      
Ile Cys Phe Tyr Arg Lys Asp Gly Ser Ala Phe Trp Cys Leu Leu Asp
            100                 105                 110         
Met Met Pro Ile Lys Asn Glu Met Gly Glu Val Val Leu Phe Leu Phe
        115                 120                 125             
Ser Phe Lys Asp Ile Thr Gln Ser Gly Ser Pro Gly Leu Gly Pro Gln
    130                 135                 140                 
Gly Gly Arg Gly Asp Ser Asn His Glu Asn Ser Leu Gly Arg Arg Gly
145                 150                 155                 160 
Ala Thr Trp Lys Phe Arg Ser Ala Arg Arg Arg Ser Arg Thr Val Leu
                165                 170                 175     
His Arg Leu Thr Gly His Phe Gly Arg Arg Gly Gln Gly Gly Met Lys
            180                 185                 190         
Ala Asn Asn Asn Val Phe Glu Pro Lys Pro Ser Val Pro Glu Tyr Lys
        195                 200                 205             
Val Ala Ser Val Gly Gly Ser Arg Cys Leu Leu Leu His Tyr Ser Val
    210                 215                 220                 
Ser Lys Ala Ile Trp Asp Gly Leu Ile Leu Leu Ala Thr Phe Tyr Val
225                 230                 235                 240 
Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ser Gly Asp Asp Asp Thr
                245                 250                 255     
Pro Ile Thr Ser Arg His Thr Leu Val Ser Asp Ile Ala Val Glu Met
            260                 265                 270         
Leu Phe Ile Leu Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser
        275                 280                 285             
Gln Ser Gly Gln Val Ile Ser Ala Pro Arg Ser Ile Gly Leu His Tyr
    290                 295                 300                 
Leu Ala Thr Trp Phe Phe Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp
305                 310                 315                 320 
Leu Leu Tyr Ile Phe Asn Ile Thr Val Thr Ser Leu Val His Leu Leu
                325                 330                 335     
Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys Leu Glu
            340                 345                 350         
Arg Tyr Ser Gln Cys Ser Ala Val Val Leu Thr Leu Leu Met Ser Val
        355                 360                 365             
Phe Ala Leu Leu Ala His Trp Met Ala Cys Ile Trp Tyr Val Ile Gly
    370                 375                 380                 
Arg Arg Glu Met Glu Ala Asn Asp Pro Leu Leu Trp Asp Ile Gly Trp
385                 390                 395                 400 
Leu His Glu Leu Gly Lys Arg Leu Glu Val Pro Tyr Val Asn Gly Ser
                405                 410                 415     
Val Gly Gly Pro Ser Arg Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe
            420                 425                 430         
Thr Leu Ser Ser Leu Thr Ser Val Gly Phe Gly Asn Val Cys Ala Asn
        435                 440                 445             
Thr Asp Ala Glu Lys Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala
    450                 455                 460                 
Leu Met His Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg
465                 470                 475                 480 
Met Tyr Ser Arg Arg Ser Leu Tyr His Ser Arg Met Lys Asp Leu Lys
                485                 490                 495     
Asp Phe Ile Arg Val His Arg Leu Pro Arg Pro Leu Lys Gln Arg Met
            500                 505                 510         
Leu Glu Tyr Phe Gln Thr Thr Trp Ala Val Asn Ser Gly Ile Asp Ala
        515                 520                 525             
Asn Glu Leu Leu Arg Asp Phe Pro Asp Glu Leu Arg Ala Asp Ile Ala
    530                 535                 540                 
Met His Leu Asn Arg Glu Ile Leu Gln Leu Pro Leu Phe Gly Ala Ala
545                 550                 555                 560 
Ser Arg Gly Cys Leu Arg Ala Leu Ser Leu His Ile Lys Thr Ser Phe
                565                 570                 575     
Cys Ala Pro Gly Glu Tyr Leu Leu Arg Arg Gly Asp Ala Leu Gln Ala
            580                 585                 590         
His Tyr Tyr Val Cys Ser Gly Ser Leu Glu Val Leu Arg Asp Asn Met
        595                 600                 605             
Val Leu Ala Ile Leu Gly Lys Gly Asp Leu Ile Gly Ala Asp Ile Pro
    610                 615                 620                 
Glu Pro Gly Gln Glu Pro Gly Leu Gly Ala Asp Pro Asn Phe Val Leu
625                 630                 635                 640 
Lys Thr Ser Ala Asp Val Lys Ala Leu Thr Tyr Cys Gly Leu Gln Gln
                645                 650                 655     
Leu Ser Ser Arg Gly Leu Ala Glu Val Leu Arg Leu Tyr Pro Glu Tyr
            660                 665                 670         
Gly Ala Ala Phe Arg Ala Gly Leu Pro Arg Asp Leu Thr Phe Asn Leu
        675                 680                 685             
Arg Gln Gly Ser Asp Thr Ser Gly Leu Ser Arg Phe Ser Arg Ser Pro
    690                 695                 700                 
Arg Leu Ser Gln Pro Arg Ser Glu Ser Leu Gly Ser Ser Ser Asp Lys
705                 710                 715                 720 
Thr Leu Pro Ser Ile Thr Glu Ala Glu Ser Gly Ala Glu Pro Gly Gly
                725                 730                 735     
Gly Pro Arg Pro Arg Arg Pro Leu Leu Leu Pro Asn Leu Ser Pro Ala
            740                 745                 750         
Arg Pro Arg Gly Ser Leu Val Ser Leu Leu Gly Glu Glu Leu Pro Pro
        755                 760                 765             
Phe Ser Ala Leu Val Ser Ser Pro Ser Leu Ser Pro Ser Leu Ser Pro
    770                 775                 780                 
Ala Leu Ala Gly Gln Gly His Ser Ala Ser Pro His Gly Pro Pro Arg
785                 790                 795                 800 
Cys Ser Ala Ala Trp Lys Pro Pro Gln Leu Leu Ile Pro Pro Leu Gly
                805                 810                 815     
Thr Phe Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly Ile Glu
            820                 825                 830         
Asp Ser Gly Ser Thr Ala Glu Ala Pro Ser Phe Arg Phe Ser Arg Arg
        835                 840                 845             
Pro Glu Leu Pro Arg Pro Arg Ser Gln Ala Pro Pro Thr Gly Thr Arg
    850                 855                 860                 
Pro Ser Pro Glu Leu Ala Ser Glu Ala Glu Glu Val Lys Glu Lys Val
865                 870                 875                 880 
Cys Arg Leu Asn Gln Glu Ile Ser Arg Leu Asn Gln Glu Val Ser Gln
                885                 890                 895     
Leu Ser Arg Glu Leu Arg His Ile Met Gly Leu Leu Gln Ala Arg Leu
            900                 905                 910         
Gly Pro Pro Gly His Pro Ala Gly Ser Ala Trp Thr Pro Asp Pro Pro
        915                 920                 925             
Cys Pro Gln Leu Arg Pro Pro Cys Leu Ser Pro Cys Ala Ser Arg Pro
    930                 935                 940                 
Pro Pro Ser Leu Gln Asp Thr Thr Leu Ala Glu Val His Cys Pro Ala
945                 950                 955                 960 
Ser Val Gly Thr Met Glu Thr Gly Thr Ala Leu Leu Asp Leu Arg Pro
                965                 970                 975     
Ser Ile Leu Pro Pro Tyr Pro Ser Glu Pro Asp Pro Leu Gly Pro Ser
            980                 985                 990         
Pro Val Pro Glu Ala Ser Pro Pro Thr Pro Ser Leu Leu Arg His Ser
        995                 1000                1005            
Phe Gln Ser Arg Ser Asp Thr Phe His
    1010                1015        


<210> 9419
<211> 2493
<212> PRT
<213> Homo sapiens

<400> 9419
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly
            20                  25                  30          
Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr
        35                  40                  45              
Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro
    50                  55                  60                  
Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu
65                  70                  75                  80  
Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu
                85                  90                  95      
Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys
            100                 105                 110         
Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro
        115                 120                 125             
Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe
    130                 135                 140                 
Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His
145                 150                 155                 160 
Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val
                165                 170                 175     
Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg
            180                 185                 190         
Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly
        195                 200                 205             
Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile
    210                 215                 220                 
Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe
225                 230                 235                 240 
Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys
                245                 250                 255     
Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys
            260                 265                 270         
Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln
        275                 280                 285             
Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile
    290                 295                 300                 
Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp
305                 310                 315                 320 
Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn
                325                 330                 335     
Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu
            340                 345                 350         
Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu
        355                 360                 365             
Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln
    370                 375                 380                 
Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu
385                 390                 395                 400 
Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro
                405                 410                 415     
Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp
            420                 425                 430         
Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser
        435                 440                 445             
Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu
    450                 455                 460                 
Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile
465                 470                 475                 480 
Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu
                485                 490                 495     
Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro
            500                 505                 510         
Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly
        515                 520                 525             
Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg
    530                 535                 540                 
Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile
545                 550                 555                 560 
Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser
                565                 570                 575     
Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys
            580                 585                 590         
Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu
        595                 600                 605             
Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe
    610                 615                 620                 
Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe
625                 630                 635                 640 
Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala
                645                 650                 655     
Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu
            660                 665                 670         
Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met
        675                 680                 685             
Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr
    690                 695                 700                 
Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala
705                 710                 715                 720 
Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln
                725                 730                 735     
Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu
            740                 745                 750         
Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln
        755                 760                 765             
Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys
    770                 775                 780                 
Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro
785                 790                 795                 800 
Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met
                805                 810                 815     
Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg
            820                 825                 830         
Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln
        835                 840                 845             
Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg
    850                 855                 860                 
Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala
865                 870                 875                 880 
Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly
                885                 890                 895     
Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu
            900                 905                 910         
Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp
        915                 920                 925             
Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg
    930                 935                 940                 
Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg
945                 950                 955                 960 
Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg
                965                 970                 975     
Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly
            980                 985                 990         
Glu Gly Glu Gly Pro Asp Gly Gly Glu Arg Arg Arg Arg His Arg His
        995                 1000                1005            
Gly Ala Pro Ala Thr Tyr Glu Gly Asp Ala Arg Arg Glu Asp Lys Glu
    1010                1015                1020                
Arg Arg His Arg Arg Arg Lys Glu Asn Gln Gly Ser Gly Val Pro Val
1025                1030                1035                1040
Ser Gly Pro Asn Leu Ser Thr Thr Arg Pro Ile Gln Gln Asp Leu Gly
                1045                1050                1055    
Arg Gln Asp Pro Pro Leu Ala Glu Asp Ile Asp Asn Met Lys Asn Asn
            1060                1065                1070        
Lys Leu Ala Thr Ala Glu Ser Ala Ala Pro His Gly Ser Leu Gly His
        1075                1080                1085            
Ala Gly Leu Pro Gln Ser Pro Ala Lys Met Gly Asn Ser Thr Asp Pro
    1090                1095                1100                
Gly Pro Met Leu Ala Ile Pro Ala Met Ala Thr Asn Pro Gln Asn Ala
1105                1110                1115                1120
Ala Ser Arg Arg Thr Pro Asn Asn Pro Gly Asn Pro Ser Asn Pro Gly
                1125                1130                1135    
Pro Pro Lys Thr Pro Glu Asn Ser Leu Ile Val Thr Asn Pro Ser Gly
            1140                1145                1150        
Thr Gln Thr Asn Ser Ala Lys Thr Ala Arg Lys Pro Asp His Thr Thr
        1155                1160                1165            
Val Asp Ile Pro Pro Ala Cys Pro Pro Pro Leu Asn His Thr Val Val
    1170                1175                1180                
Gln Val Asn Lys Asn Ala Asn Pro Asp Pro Leu Pro Lys Lys Glu Glu
1185                1190                1195                1200
Glu Lys Lys Glu Glu Glu Glu Asp Asp Arg Gly Glu Asp Gly Pro Lys
                1205                1210                1215    
Pro Met Pro Pro Tyr Ser Ser Met Phe Ile Leu Ser Thr Thr Asn Pro
            1220                1225                1230        
Leu Arg Arg Leu Cys His Tyr Ile Leu Asn Leu Arg Tyr Phe Glu Met
        1235                1240                1245            
Cys Ile Leu Met Val Ile Ala Met Ser Ser Ile Ala Leu Ala Ala Glu
    1250                1255                1260                
Asp Pro Val Gln Pro Asn Ala Pro Arg Asn Asn Val Leu Arg Tyr Phe
1265                1270                1275                1280
Asp Tyr Val Phe Thr Gly Val Phe Thr Phe Glu Met Val Ile Lys Met
                1285                1290                1295    
Ile Asp Leu Gly Leu Val Leu His Gln Gly Ala Tyr Phe Arg Asp Leu
            1300                1305                1310        
Trp Asn Ile Leu Asp Phe Ile Val Val Ser Gly Ala Leu Val Ala Phe
        1315                1320                1325            
Ala Phe Thr Gly Asn Ser Lys Gly Lys Asp Ile Asn Thr Ile Lys Ser
    1330                1335                1340                
Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg Leu
1345                1350                1355                1360
Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val Asn Ser Leu Lys Asn
                1365                1370                1375    
Val Phe Asn Ile Leu Ile Val Tyr Met Leu Phe Met Phe Ile Phe Ala
            1380                1385                1390        
Val Val Ala Val Gln Leu Phe Lys Gly Lys Phe Phe His Cys Thr Asp
        1395                1400                1405            
Glu Ser Lys Glu Phe Glu Lys Asp Cys Arg Gly Lys Tyr Leu Leu Tyr
    1410                1415                1420                
Glu Lys Asn Glu Val Lys Ala Arg Asp Arg Glu Trp Lys Lys Tyr Glu
1425                1430                1435                1440
Phe His Tyr Asp Asn Val Leu Trp Ala Leu Leu Thr Leu Phe Thr Val
                1445                1450                1455    
Ser Thr Gly Glu Gly Trp Pro Gln Val Leu Lys His Ser Val Asp Ala
            1460                1465                1470        
Thr Phe Glu Asn Gln Gly Pro Ser Pro Gly Tyr Arg Met Glu Met Ser
        1475                1480                1485            
Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro Phe Phe Phe Val Asn
    1490                1495                1500                
Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln Glu Gln Gly Asp Lys
1505                1510                1515                1520
Met Met Glu Glu Tyr Ser Leu Glu Lys Asn Glu Arg Ala Cys Ile Asp
                1525                1530                1535    
Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg His Met Pro Gln Asn Lys
            1540                1545                1550        
Gln Ser Phe Gln Tyr Arg Met Trp Gln Phe Val Val Ser Pro Pro Phe
        1555                1560                1565            
Glu Tyr Thr Ile Met Ala Met Ile Ala Leu Asn Thr Ile Val Leu Met
    1570                1575                1580                
Met Lys Phe Tyr Gly Ala Ser Val Ala Tyr Glu Asn Ala Leu Arg Val
1585                1590                1595                1600
Phe Asn Ile Val Phe Thr Ser Leu Phe Ser Leu Glu Cys Val Leu Lys
                1605                1610                1615    
Val Met Ala Phe Gly Ile Leu Asn Tyr Phe Arg Asp Ala Trp Asn Ile
            1620                1625                1630        
Phe Asp Phe Val Thr Val Leu Gly Ser Ile Thr Asp Ile Leu Val Thr
        1635                1640                1645            
Glu Phe Gly Asn Asn Phe Ile Asn Leu Ser Phe Leu Arg Leu Phe Arg
    1650                1655                1660                
Ala Ala Arg Leu Ile Lys Leu Leu Arg Gln Gly Tyr Thr Ile Arg Ile
1665                1670                1675                1680
Leu Leu Trp Thr Phe Val Gln Ser Phe Lys Ala Leu Pro Tyr Val Cys
                1685                1690                1695    
Leu Leu Ile Ala Met Leu Phe Phe Ile Tyr Ala Ile Ile Gly Met Gln
            1700                1705                1710        
Val Phe Gly Asn Ile Gly Ile Asp Val Glu Asp Glu Asp Ser Asp Glu
        1715                1720                1725            
Asp Glu Phe Gln Ile Thr Glu His Asn Asn Phe Arg Thr Phe Phe Gln
    1730                1735                1740                
Ala Leu Met Leu Leu Phe Arg Ser Ala Thr Gly Glu Ala Trp His Asn
1745                1750                1755                1760
Ile Met Leu Ser Cys Leu Ser Gly Lys Pro Cys Asp Lys Asn Ser Gly
                1765                1770                1775    
Ile Leu Thr Arg Glu Cys Gly Asn Glu Phe Ala Tyr Phe Tyr Phe Val
            1780                1785                1790        
Ser Phe Ile Phe Leu Cys Ser Phe Leu Met Leu Asn Leu Phe Val Ala
        1795                1800                1805            
Val Ile Met Asp Asn Phe Glu Tyr Leu Thr Arg Asp Ser Ser Ile Leu
    1810                1815                1820                
Gly Pro His His Leu Asp Glu Tyr Val Arg Val Trp Ala Glu Tyr Asp
1825                1830                1835                1840
Pro Ala Ala Trp Gly Arg Met Pro Tyr Leu Asp Met Tyr Gln Met Leu
                1845                1850                1855    
Arg His Met Ser Pro Pro Leu Gly Leu Gly Lys Lys Cys Pro Ala Arg
            1860                1865                1870        
Val Ala Tyr Lys Arg Leu Leu Arg Met Asp Leu Pro Val Ala Asp Asp
        1875                1880                1885            
Asn Thr Val His Phe Asn Ser Thr Leu Met Ala Leu Ile Arg Thr Ala
    1890                1895                1900                
Leu Asp Ile Lys Ile Ala Lys Gly Gly Ala Asp Lys Gln Gln Met Asp
1905                1910                1915                1920
Ala Glu Leu Arg Lys Glu Met Met Ala Ile Trp Pro Asn Leu Ser Gln
                1925                1930                1935    
Lys Thr Leu Asp Leu Leu Val Thr Pro His Lys Ser Thr Asp Leu Thr
            1940                1945                1950        
Val Gly Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr Arg Gln
        1955                1960                1965            
Ser Lys Ala Lys Lys Leu Gln Ala Met Arg Glu Glu Gln Asp Arg Thr
    1970                1975                1980                
Pro Leu Met Phe Gln Arg Met Glu Pro Pro Ser Pro Thr Gln Glu Gly
1985                1990                1995                2000
Gly Pro Gly Gln Asn Ala Leu Pro Ser Thr Gln Leu Asp Pro Gly Gly
                2005                2010                2015    
Ala Leu Met Ala His Glu Ser Gly Leu Lys Glu Ser Pro Ser Trp Val
            2020                2025                2030        
Thr Gln Arg Ala Gln Glu Met Phe Gln Lys Thr Gly Thr Trp Ser Pro
        2035                2040                2045            
Glu Gln Gly Pro Pro Thr Asp Met Pro Asn Ser Gln Pro Asn Ser Gln
    2050                2055                2060                
Ser Val Glu Met Arg Glu Met Gly Arg Asp Gly Tyr Ser Asp Ser Glu
2065                2070                2075                2080
His Tyr Leu Pro Met Glu Gly Gln Gly Arg Ala Ala Ser Met Pro Arg
                2085                2090                2095    
Leu Pro Ala Glu Asn Gln Thr Ile Ser Asp Thr Ser Pro Met Lys Arg
            2100                2105                2110        
Ser Ala Ser Val Leu Gly Pro Lys Ala Arg Arg Leu Asp Asp Tyr Ser
        2115                2120                2125            
Leu Glu Arg Val Pro Pro Glu Glu Asn Gln Arg His His Gln Arg Arg
    2130                2135                2140                
Arg Asp Arg Ser His Arg Ala Ser Glu Arg Ser Leu Gly Arg Tyr Thr
2145                2150                2155                2160
Asp Val Asp Thr Gly Leu Gly Thr Asp Leu Ser Met Thr Thr Gln Ser
                2165                2170                2175    
Gly Asp Leu Pro Ser Lys Glu Arg Asp Gln Glu Arg Gly Arg Pro Lys
            2180                2185                2190        
Asp Arg Lys His Arg Gln His His His His His His His His His His
        2195                2200                2205            
Pro Pro Pro Pro Asp Lys Asp Arg Tyr Ala Gln Glu Arg Pro Asp His
    2210                2215                2220                
Gly Arg Ala Arg Ala Arg Asp Gln Arg Trp Ser Arg Ser Pro Ser Glu
2225                2230                2235                2240
Gly Arg Glu His Met Ala His Arg Gln Gly Ser Ser Ser Val Ser Gly
                2245                2250                2255    
Ser Pro Ala Pro Ser Thr Ser Gly Thr Ser Thr Pro Arg Arg Gly Arg
            2260                2265                2270        
Arg Gln Leu Pro Gln Thr Pro Ser Thr Pro Arg Pro His Val Ser Tyr
        2275                2280                2285            
Ser Pro Val Ile Arg Lys Ala Gly Gly Ser Gly Pro Pro Gln Gln Gln
    2290                2295                2300                
Gln Gln Gln Gln Gln Gln Gln Gln Ala Val Ala Arg Pro Gly Arg Ala
2305                2310                2315                2320
Ala Thr Ser Gly Pro Arg Arg Tyr Pro Gly Pro Thr Ala Glu Pro Leu
                2325                2330                2335    
Ala Gly Asp Arg Pro Pro Thr Gly Gly His Ser Ser Gly Arg Ser Pro
            2340                2345                2350        
Arg Met Glu Arg Arg Val Pro Gly Pro Ala Arg Ser Glu Ser Pro Arg
        2355                2360                2365            
Ala Cys Arg His Gly Gly Ala Arg Trp Pro Ala Ser Gly Pro His Val
    2370                2375                2380                
Ser Glu Gly Pro Pro Gly Pro Arg His His Gly Tyr Tyr Arg Gly Ser
2385                2390                2395                2400
Asp Tyr Asp Glu Ala Asp Gly Pro Gly Ser Gly Gly Gly Glu Glu Ala
                2405                2410                2415    
Met Ala Gly Ala Tyr Asp Ala Pro Pro Pro Val Arg His Ala Ser Ser
            2420                2425                2430        
Gly Ala Thr Gly Arg Ser Pro Arg Thr Pro Arg Ala Ser Gly Pro Ala
        2435                2440                2445            
Cys Ala Ser Pro Ser Arg His Gly Arg Arg Leu Pro Asn Gly Tyr Tyr
    2450                2455                2460                
Pro Ala His Gly Leu Ala Arg Pro Arg Gly Pro Gly Ser Arg Lys Gly
2465                2470                2475                2480
Leu His Glu Pro Tyr Ser Glu Ser Asp Asp Asp Trp Cys
                2485                2490            


<210> 9420
<211> 314
<212> PRT
<213> Homo sapiens

<400> 9420
Met Gly Asp Val Asn Gln Ser Val Ala Ser Asp Phe Ile Leu Val Gly
 1               5                  10                  15      
Leu Phe Ser His Ser Gly Ser Arg Gln Leu Leu Phe Ser Leu Val Ala
            20                  25                  30          
Val Met Phe Val Ile Gly Leu Leu Gly Asn Thr Val Leu Leu Phe Leu
        35                  40                  45              
Ile Arg Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser
    50                  55                  60                  
Gln Leu Ser Leu Phe Asp Ile Gly Cys Pro Met Val Thr Ile Pro Lys
65                  70                  75                  80  
Met Ala Ser Asp Phe Leu Arg Gly Glu Gly Ala Thr Ser Tyr Gly Gly
                85                  90                  95      
Gly Ala Ala Gln Ile Phe Phe Leu Thr Leu Met Gly Val Ala Glu Gly
            100                 105                 110         
Val Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Gln
        115                 120                 125             
Pro Leu Gln Tyr Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met
    130                 135                 140                 
Met Gly Ser Ser Trp Val Val Gly Val Leu Asn Ala Ser Ile Gln Thr
145                 150                 155                 160 
Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser Arg Ile Val Asp His
                165                 170                 175     
Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr
            180                 185                 190         
Cys Ala Tyr Glu Met Ala Leu Ser Thr Ser Gly Val Leu Ile Leu Met
        195                 200                 205             
Leu Pro Leu Ser Leu Ile Ala Thr Ser Tyr Gly His Val Leu Gln Ala
    210                 215                 220                 
Val Leu Ser Met Arg Ser Glu Glu Ala Arg His Lys Ala Val Thr Thr
225                 230                 235                 240 
Cys Ser Ser His Ile Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Val
                245                 250                 255     
Phe Met Tyr Met Val Pro Cys Ala Tyr His Ser Pro Gln Gln Asp Asn
            260                 265                 270         
Val Val Ser Leu Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn Pro Leu
        275                 280                 285             
Ile Tyr Ser Leu Arg Asn Pro Glu Val Trp Met Ala Leu Val Lys Val
    290                 295                 300                 
Leu Ser Arg Ala Gly Leu Arg Gln Met Cys
305                 310                 


<210> 9421
<211> 337
<212> PRT
<213> Homo sapiens

<400> 9421
Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu
 1               5                  10                  15      
Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe
            20                  25                  30          
Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly
        35                  40                  45              
Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val
    50                  55                  60                  
Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser
65                  70                  75                  80  
Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile
                85                  90                  95      
Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala
            100                 105                 110         
Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala
        115                 120                 125             
Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr
    130                 135                 140                 
Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp
145                 150                 155                 160 
Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys
                165                 170                 175     
Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser
            180                 185                 190         
Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly
        195                 200                 205             
Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe
    210                 215                 220                 
Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu
225                 230                 235                 240 
His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala
                245                 250                 255     
His Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile
            260                 265                 270         
Phe Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile
        275                 280                 285             
Asn Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro
    290                 295                 300                 
Ala Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg
305                 310                 315                 320 
Ala Trp Ser Gly Phe Ser Phe Asp Phe Ile Phe Thr Gln Lys Ser Gly
                325                 330                 335     
Leu
    


<210> 9422
<211> 695
<212> PRT
<213> Homo sapiens

<400> 9422
Met Ser Gly Ala Ala Leu Gly Leu Glu Ile Val Phe Val Phe Phe Leu
 1               5                  10                  15      
Ala Leu Phe Leu Leu His Arg Tyr Gly Asp Phe Lys Lys Gln His Arg
            20                  25                  30          
Leu Val Ile Ile Gly Thr Leu Leu Ala Trp Tyr Leu Cys Phe Leu Ile
        35                  40                  45              
Val Phe Ile Leu Pro Leu Asp Val Ser Thr Thr Ile Tyr Asn Arg Cys
    50                  55                  60                  
Lys His Ala Ala Ala Asn Ser Ser Pro Pro Glu Asn Ser Asn Ile Thr
65                  70                  75                  80  
Gly Leu Tyr Ala Thr Ala Asn Pro Val Pro Ser Gln His Pro Cys Phe
                85                  90                  95      
Lys Pro Trp Ser Tyr Ile Pro Asp Gly Ile Met Pro Ile Phe Trp Arg
            100                 105                 110         
Val Val Tyr Trp Thr Ser Gln Phe Leu Thr Trp Ile Leu Leu Pro Phe
        115                 120                 125             
Met Gln Ser Tyr Ala Arg Ser Gly Gly Phe Ser Ile Thr Gly Lys Ile
    130                 135                 140                 
Lys Thr Ala Leu Ile Glu Asn Ala Ile Tyr Tyr Gly Thr Tyr Leu Leu
145                 150                 155                 160 
Ile Phe Gly Ala Phe Leu Ile Tyr Val Ala Val Asn Pro His Leu His
                165                 170                 175     
Leu Glu Trp Asn Gln Leu Gln Thr Ile Gly Ile Ala Ala Ala Asn Thr
            180                 185                 190         
Trp Gly Leu Phe Leu Leu Val Leu Leu Leu Gly Tyr Gly Leu Val Glu
        195                 200                 205             
Ile Pro Arg Ser Tyr Trp Asn Gly Ala Lys Arg Gly Tyr Leu Leu Met
    210                 215                 220                 
Lys Thr Tyr Phe Lys Ala Ala Lys Leu Met Thr Glu Lys Ala Asp Ala
225                 230                 235                 240 
Glu Glu Asn Leu Glu Asp Ala Met Glu Glu Val Arg Lys Val Asn Glu
                245                 250                 255     
Ser Ile Lys Tyr Asn His Pro Leu Arg Lys Cys Val Asp Thr Ile Leu
            260                 265                 270         
Lys Lys Cys Pro Thr Glu Tyr Gln Glu Lys Met Gly Arg Asn Met Asp
        275                 280                 285             
Asp Tyr Glu Asp Phe Asp Glu Lys His Ser Ile Tyr Pro Ser Glu Lys
    290                 295                 300                 
Ser Leu Val Lys Leu His Lys Gln Val Ile Tyr Ser Val Gln Arg His
305                 310                 315                 320 
Arg Arg Thr Gln Val Gln Trp Gln Ile Leu Leu Glu Gln Ala Phe Tyr
                325                 330                 335     
Leu Glu Asp Val Ala Lys Asn Glu Thr Ser Ala Thr His Gln Phe Val
            340                 345                 350         
His Thr Phe Gln Ser Pro Glu Pro Glu Asn Arg Phe Ile Gln Tyr Phe
        355                 360                 365             
Tyr Asn Pro Thr Phe Glu Trp Tyr Trp Glu Cys Leu Leu Arg Pro Trp
    370                 375                 380                 
Phe Tyr Lys Ile Leu Ala Val Val Leu Ser Ile Phe Ser Val Ile Val
385                 390                 395                 400 
Val Trp Ser Glu Cys Thr Phe Phe Ser Thr Thr Pro Val Leu Ser Leu
                405                 410                 415     
Phe Ala Val Phe Ile Gln Leu Ala Glu Lys Thr Tyr Asn Tyr Ile Tyr
            420                 425                 430         
Ile Glu Ile Ala Cys Phe Leu Ser Ile Phe Phe Leu Ser Ile Cys Val
        435                 440                 445             
Tyr Ser Thr Val Phe Arg Ile Arg Val Phe Asn Tyr Tyr Tyr Leu Ala
    450                 455                 460                 
Ser His His Gln Thr Asp Ala Tyr Ser Leu Leu Phe Ser Gly Met Leu
465                 470                 475                 480 
Phe Cys Arg Leu Thr Pro Pro Leu Cys Leu Asn Phe Leu Gly Leu Thr
                485                 490                 495     
His Met Asp Ser Ser Ile Ser His Lys Asn Thr Gln Pro Thr Ala Tyr
            500                 505                 510         
Thr Ser Ile Met Gly Ser Met Lys Val Leu Ser Phe Ile Ala Asp Gly
        515                 520                 525             
Phe Tyr Ile Tyr Tyr Pro Met Leu Val Val Ile Leu Cys Ile Ala Thr
    530                 535                 540                 
Tyr Phe Ser Leu Gly Thr Arg Cys Leu Asn Leu Leu Gly Phe Gln Gln
545                 550                 555                 560 
Phe Met Gly Asp Asp Asp Met Thr Ser Asp Leu Val Asn Glu Gly Lys
                565                 570                 575     
Glu Leu Ile Arg Lys Glu Lys Arg Lys Arg Gln Arg Gln Glu Glu Gly
            580                 585                 590         
Glu Asn Arg Arg Arg Glu Trp Lys Glu Arg Tyr Gly His Asn Arg Glu
        595                 600                 605             
Asp Ser Thr Arg Asn Arg Asn Ile His Thr Asp Pro Lys Glu Ser Asn
    610                 615                 620                 
Phe Ser Asp Val Asn Thr Asn Arg Ser Ala Phe Lys Tyr Thr Arg Ala
625                 630                 635                 640 
Asn Asn Arg Thr Glu Arg Asp Arg Ile Glu Leu Leu Gln Asp Ala Glu
                645                 650                 655     
Pro Leu Asp Phe Asn Ala Glu Thr Phe Thr Asp Asp Pro Leu Glu Ser
            660                 665                 670         
Glu Ser Gly Arg Tyr Gln Pro Gly Gly Arg Tyr Leu Ser Met Ser Arg
        675                 680                 685             
Ser Asp Ile Phe Asn Asp Val
    690                 695 


<210> 9423
<211> 622
<212> PRT
<213> Homo sapiens

<400> 9423
Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr
 1               5                  10                  15      
Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn
            20                  25                  30          
Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala
        35                  40                  45              
Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys
    50                  55                  60                  
Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp
65                  70                  75                  80  
Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln
                85                  90                  95      
Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg
            100                 105                 110         
Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys
        115                 120                 125             
Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp
    130                 135                 140                 
Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn
145                 150                 155                 160 
Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly
                165                 170                 175     
Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu
            180                 185                 190         
Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn
        195                 200                 205             
Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln
    210                 215                 220                 
Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp
225                 230                 235                 240 
Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp
                245                 250                 255     
Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn
            260                 265                 270         
Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser
        275                 280                 285             
Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser
    290                 295                 300                 
Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp
305                 310                 315                 320 
Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe
                325                 330                 335     
Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr
            340                 345                 350         
Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg
        355                 360                 365             
Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser
    370                 375                 380                 
Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg
385                 390                 395                 400 
Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn
                405                 410                 415     
Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly
            420                 425                 430         
Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg
        435                 440                 445             
Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly
    450                 455                 460                 
Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro
465                 470                 475                 480 
Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg
                485                 490                 495     
Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly
            500                 505                 510         
Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro
        515                 520                 525             
Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro
    530                 535                 540                 
Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly
545                 550                 555                 560 
Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro
                565                 570                 575     
Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu
            580                 585                 590         
Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Ser Lys Ser
        595                 600                 605             
Lys Pro Ser Leu Gln Pro Gly Gly Gln Gly Ser Ala Cys Ala
    610                 615                 620         


<210> 9424
<211> 800
<212> PRT
<213> Homo sapiens

<400> 9424
Ala Gly Ser Ala Gly Ser Ala Gly Arg Arg Arg Arg Gly Arg Thr Gly
 1               5                  10                  15      
Ala Gln Thr Ala Gly Ala Arg Arg Gly Tyr His Gly Arg Ala Val Ser
            20                  25                  30          
Ser Arg Ser Gly Arg Leu Pro Arg Leu Arg Gly Ala Arg Ala Glu Leu
        35                  40                  45              
Pro Gly Arg Arg Cys Val Pro Thr Val Thr Met Lys Asp Asp Phe Ala
    50                  55                  60                  
Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr Lys Arg Phe Gly Ile Gln
65                  70                  75                  80  
Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn Asn Trp Ala Leu Lys Phe
                85                  90                  95      
Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala Leu Leu Thr Ile Thr Val
            100                 105                 110         
Ala Ile Leu Gly Tyr Lys Val Val Glu Lys Met Asp Asn Val Thr Gly
        115                 120                 125             
Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp Asp Lys Leu Thr Ala Val
    130                 135                 140                 
Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln Thr Gly Lys Lys Ala Ile
145                 150                 155                 160 
Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg Ser Asp Ile Leu Asp Leu
                165                 170                 175     
Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys Thr Ser Lys Asn Lys Asp
            180                 185                 190         
Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp Ala Leu Val Asp Arg Gln
        195                 200                 205             
Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn Ser Phe Leu Ile Thr Thr
    210                 215                 220                 
Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly Tyr Val Thr Asn Leu Gln
225                 230                 235                 240 
Gln Asp Thr Ser Val Leu Gln Gly Asn Leu Gln Asn Gln Met Tyr Ser
                245                 250                 255     
His Asn Val Val Ile Met Asn Leu Asn Asn Leu Asn Leu Thr Gln Val
            260                 265                 270         
Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln Arg Ser Val Asp Asp Thr
        275                 280                 285             
Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp Phe Gln Asn Leu Gln Gln
    290                 295                 300                 
Val Phe Leu Gln Ala Lys Lys Asp Thr Asp Trp Leu Lys Glu Lys Val
305                 310                 315                 320 
Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn Ser Ala Leu Ala Lys Ala
                325                 330                 335     
Asn Asn Asp Thr Leu Glu Asp Met Asn Ser Gln Leu Asn Ser Phe Thr
            340                 345                 350         
Gly Gln Met Glu Asn Ile Thr Thr Ile Ser Gln Ala Asn Glu Gln Asn
        355                 360                 365             
Leu Lys Asp Leu Gln Asp Leu His Lys Asp Ala Glu Asn Arg Thr Ala
    370                 375                 380                 
Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe Gln Leu Phe Glu Thr Asp
385                 390                 395                 400 
Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr Thr Ala His His Leu Arg
                405                 410                 415     
Thr Leu Thr Ser Asn Leu Asn Glu Val Arg Thr Thr Cys Thr Asp Thr
            420                 425                 430         
Leu Thr Lys His Thr Asp Asp Leu Thr Ser Leu Asn Asn Thr Leu Ala
        435                 440                 445             
Asn Ile Arg Leu Asp Ser Val Ser Leu Arg Met Gln Gln Asp Leu Met
    450                 455                 460                 
Arg Ser Arg Leu Asp Thr Glu Val Ala Asn Leu Ser Val Ile Met Glu
465                 470                 475                 480 
Glu Met Lys Leu Val Asp Ser Lys His Gly Gln Leu Ile Lys Asn Phe
                485                 490                 495     
Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg Gly Pro Arg Gly Asp Arg
            500                 505                 510         
Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly Asn Lys Gly Gln Lys Gly
        515                 520                 525             
Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Glu Arg Gly Pro
    530                 535                 540                 
Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg Gly Gly Lys Gly Ser Lys
545                 550                 555                 560 
Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly Ser Pro Gly Lys Pro Gly
                565                 570                 575     
Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro Pro Gly Pro Pro Gly Lys
            580                 585                 590         
Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro Gly Phe Gln Gly Leu Gln
        595                 600                 605             
Gly Thr Val Gly Glu Pro Gly Val Pro Gly Pro Arg Gly Leu Pro Gly
    610                 615                 620                 
Leu Pro Gly Val Pro Gly Met Pro Gly Pro Lys Gly Pro Pro Gly Pro
625                 630                 635                 640 
Pro Gly Pro Ser Gly Ala Val Val Pro Leu Ala Leu Gln Asn Glu Pro
                645                 650                 655     
Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro Pro His Trp Lys Asn Phe
            660                 665                 670         
Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu Lys Glu Ile Phe Glu Asp
        675                 680                 685             
Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser His Leu Val Phe Ile Asn
    690                 695                 700                 
Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys Gln Met Val Gly Arg Glu
705                 710                 715                 720 
Ser His Trp Ile Gly Leu Thr Asp Ser Glu Arg Glu Asn Glu Trp Lys
                725                 730                 735     
Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys Asn Trp Lys Ala Gly Gln
            740                 745                 750         
Pro Asp Asn Trp Gly His Gly His Gly Pro Gly Glu Asp Cys Ala Gly
        755                 760                 765             
Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe Gln Cys Glu Asp Val Asn
    770                 775                 780                 
Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr Val Leu Ser Ser Ala Leu
785                 790                 795                 800 


<210> 9425
<211> 2849
<212> PRT
<213> Homo sapiens

<400> 9425
Met Ala Glu Glu Ala Ala Gln Asn Ile Ser Asp Asp Gln Glu Arg Cys
 1               5                  10                  15      
Leu Gln Ala Ala Cys Cys Leu Ser Phe Gly Gly Glu Leu Ser Val Ser
            20                  25                  30          
Thr Asp Lys Ser Trp Gly Leu His Leu Cys Ser Cys Ser Pro Pro Gly
        35                  40                  45              
Gly Gly Leu Trp Val Glu Val Tyr Ala Asn His Val Leu Leu Met Ser
    50                  55                  60                  
Asp Gly Lys Cys Gly Cys Pro Trp Cys Ala Leu Asn Gly Lys Ala Glu
65                  70                  75                  80  
Asp Arg Glu Ser Gln Ser Pro Ser Ser Ser Ala Ser Arg Gln Lys Asn
                85                  90                  95      
Ile Trp Lys Thr Thr Ser Glu Ala Ala Leu Ser Val Val Asn Glu Lys
            100                 105                 110         
Thr Gln Ala Val Val Asn Glu Lys Thr Gln Ala Pro Leu Asp Cys Asp
        115                 120                 125             
Asn Ser Ala Asp Arg Ile Pro His Lys Pro Phe Ile Ile Ile Ala Arg
    130                 135                 140                 
Ala Trp Ser Ser Gly Gly Pro Arg Phe His His Arg Arg Leu Cys Ala
145                 150                 155                 160 
Thr Gly Thr Ala Asp Ser Thr Phe Ser Ala Leu Leu Gln Leu Gln Gly
                165                 170                 175     
Thr Thr Ser Ala Ala Ala Pro Cys Ser Leu Lys Met Glu Ala Ser Cys
            180                 185                 190         
Cys Val Leu Arg Leu Leu Cys Cys Ala Glu Asp Val Ala Thr Gly Leu
        195                 200                 205             
Leu Pro Gly Thr Val Thr Met Glu Thr Pro Thr Lys Val Ala Arg Pro
    210                 215                 220                 
Thr Gln Thr Ser Ser Gln Arg Val Pro Leu Trp Pro Ile Ser His Phe
225                 230                 235                 240 
Pro Thr Ser Pro Arg Ser Ser His Gly Leu Pro Pro Gly Ile Pro Arg
                245                 250                 255     
Thr Pro Ser Phe Thr Ala Ser Gln Ser Gly Ser Glu Ile Leu Tyr Pro
            260                 265                 270         
Pro Thr Gln His Pro Pro Val Ala Ile Leu Ala Arg Asn Ser Asp Asn
        275                 280                 285             
Phe Met Asn Pro Val Leu Asn Cys Ser Leu Glu Val Glu Ala Arg Ala
    290                 295                 300                 
Pro Pro Asn Leu Gly Phe Arg Val His Met Ala Ser Gly Glu Ala Leu
305                 310                 315                 320 
Cys Leu Met Met Asp Phe Gly Asp Ser Ser Gly Val Glu Met Arg Leu
                325                 330                 335     
His Asn Met Ser Glu Ala Met Ala Val Thr Ala Tyr His Gln Tyr Ser
            340                 345                 350         
Lys Gly Ile Phe Phe His Leu Leu His Phe Gln Leu Asp Met Ser Thr
        355                 360                 365             
Tyr Lys Glu Ala Glu Thr Gln Asn Thr Thr Leu Asn Val Tyr Leu Cys
    370                 375                 380                 
Gln Ser Glu Asn Ser Cys Leu Glu Asp Ser Asp Pro Ser Asn Leu Gly
385                 390                 395                 400 
Tyr Glu Leu Ile Ser Ala Phe Val Thr Lys Gly Val Tyr Met Leu Lys
                405                 410                 415     
Ala Val Ile Tyr Asn Glu Phe His Gly Thr Glu Val Glu Leu Gly Pro
            420                 425                 430         
Tyr Tyr Val Glu Ile Gly His Glu Ala Val Ser Ala Phe Met Asn Ser
        435                 440                 445             
Ser Ser Val His Glu Asp Glu Val Leu Val Phe Ala Asp Ser Gln Val
    450                 455                 460                 
Asn Gln Lys Ser Thr Val Val Ile His His Phe Pro Ser Ile Pro Ser
465                 470                 475                 480 
Tyr Asn Val Ser Phe Ile Ser Gln Thr Gln Val Gly Asp Ser Gln Ala
                485                 490                 495     
Trp His Ser Met Thr Val Trp Tyr Lys Met Gln Ser Val Ser Val Tyr
            500                 505                 510         
Thr Asn Gly Thr Val Phe Ala Thr Asp Thr Asp Ile Thr Phe Thr Ala
        515                 520                 525             
Val Thr Lys Glu Thr Ile Pro Leu Glu Phe Glu Trp Tyr Phe Gly Glu
    530                 535                 540                 
Asp Pro Pro Val Arg Thr Thr Ser Arg Ser Ile Lys Lys Arg Leu Ser
545                 550                 555                 560 
Ile Pro Gln Trp Tyr Arg Val Met Val Lys Ala Ser Asn Arg Met Ser
                565                 570                 575     
Ser Val Val Ser Glu Pro His Val Ile Arg Val Gln Lys Lys Ile Val
            580                 585                 590         
Ala Asn Arg Leu Thr Ser Pro Ser Ser Ala Leu Val Asn Ala Ser Val
        595                 600                 605             
Ala Phe Glu Cys Trp Ile Asn Phe Gly Thr Asp Val Ala Tyr Leu Trp
    610                 615                 620                 
Asp Phe Gly Asp Gly Thr Val Ser Leu Gly Ser Ser Ser Ser Ser His
625                 630                 635                 640 
Val Tyr Ser Arg Glu Gly Glu Phe Thr Val Glu Val Leu Ala Phe Asn
                645                 650                 655     
Asn Val Ser Ala Ser Thr Leu Arg Gln Gln Leu Phe Ile Val Cys Glu
            660                 665                 670         
Pro Cys Gln Pro Pro Leu Val Lys Asn Met Gly Pro Gly Lys Val Gln
        675                 680                 685             
Ile Trp Arg Ser Gln Pro Val Arg Leu Gly Val Thr Phe Glu Ala Ala
    690                 695                 700                 
Val Phe Cys Asp Ile Ser Gln Gly Leu Ser Tyr Thr Trp Asn Leu Met
705                 710                 715                 720 
Asp Ser Glu Gly Leu Pro Val Ser Leu Pro Ala Ala Val Asp Thr His
                725                 730                 735     
Arg Gln Thr Leu Ile Leu Pro Ser His Thr Leu Glu Tyr Gly Asn Tyr
            740                 745                 750         
Thr Ala Leu Ala Lys Val Gln Ile Glu Gly Ser Val Val Tyr Ser Asn
        755                 760                 765             
Tyr Cys Val Gly Leu Glu Val Arg Ala Gln Ala Pro Val Ser Val Ile
    770                 775                 780                 
Ser Glu Gly Thr His Leu Phe Phe Ser Arg Thr Thr Ser Ser Pro Ile
785                 790                 795                 800 
Val Leu Arg Gly Thr Gln Ser Phe Asp Pro Asp Asp Pro Gly Ala Thr
                805                 810                 815     
Leu Arg Tyr His Trp Glu Cys Ala Thr Ala Gly Ser Pro Ala His Pro
            820                 825                 830         
Cys Phe Asp Ser Ser Thr Ala His Gln Leu Asp Ala Ala Ala Pro Thr
        835                 840                 845             
Val Ser Phe Glu Ala Gln Trp Leu Ser Asp Ser Tyr Asp Gln Phe Leu
    850                 855                 860                 
Val Met Leu Arg Val Ser Ser Gly Gly Arg Asn Ser Ser Glu Thr Arg
865                 870                 875                 880 
Val Phe Leu Ser Pro Tyr Pro Asp Ser Ala Phe Arg Phe Val His Ile
                885                 890                 895     
Ser Trp Val Ser Phe Lys Asp Thr Phe Val Asn Trp Asn Asp Glu Leu
            900                 905                 910         
Ser Leu Gln Ala Met Cys Glu Asp Cys Ser Glu Ile Pro Asn Leu Ser
        915                 920                 925             
Tyr Ser Trp Asp Leu Phe Leu Val Asn Ala Thr Glu Lys Asn Arg Ile
    930                 935                 940                 
Glu Val Pro Phe Cys Arg Val Val Gly Leu Leu Gly Ser Leu Gly Leu
945                 950                 955                 960 
Gly Ala Ile Ser Glu Ser Ser Gln Leu Asn Leu Leu Pro Thr Glu Pro
                965                 970                 975     
Gly Thr Ala Asp Pro Asp Ala Thr Thr Thr Pro Phe Ser Arg Glu Pro
            980                 985                 990         
Ser Pro Val Thr Leu Gly Gln Pro Ala Thr Ser Ala Pro Arg Gly Thr
        995                 1000                1005            
Pro Thr Glu Pro Met Thr Gly Val Tyr Trp Ile Pro Pro Ala Gly Asp
    1010                1015                1020                
Ser Ala Val Leu Gly Glu Ala Pro Glu Glu Gly Ser Leu Asp Leu Glu
1025                1030                1035                1040
Pro Gly Pro Gln Ser Lys Gly Ser Leu Met Thr Gly Arg Ser Glu Arg
                1045                1050                1055    
Ser Gln Pro Thr His Ser Pro Asp Pro His Leu Ser Asp Phe Glu Ala
            1060                1065                1070        
Tyr Tyr Ser Asp Ile Gln Glu Ala Ile Pro Ser Gly Gly Arg Gln Pro
        1075                1080                1085            
Ala Lys Asp Thr Ser Phe Pro Gly Ser Gly Pro Ser Leu Ser Ala Glu
    1090                1095                1100                
Glu Ser Pro Gly Asp Gly Asp Asn Leu Val Asp Pro Ser Leu Ser Ala
1105                1110                1115                1120
Gly Arg Ala Glu Pro Val Leu Met Ile Asp Trp Pro Lys Ala Leu Leu
                1125                1130                1135    
Gly Arg Ala Val Phe Gln Gly Tyr Ser Ser Ser Gly Ile Thr Glu Gln
            1140                1145                1150        
Thr Val Thr Ile Lys Pro Tyr Ser Leu Ser Ser Gly Glu Thr Tyr Val
        1155                1160                1165            
Leu Gln Val Ser Val Ala Ser Lys His Gly Leu Leu Gly Lys Ala Gln
    1170                1175                1180                
Leu Tyr Leu Thr Val Asn Pro Ala Pro Arg Asp Met Ala Cys Gln Val
1185                1190                1195                1200
Gln Pro His His Gly Leu Glu Ala His Thr Val Phe Ser Val Phe Cys
                1205                1210                1215    
Met Ser Gly Lys Pro Asp Phe His Tyr Glu Phe Ser Tyr Gln Ile Gly
            1220                1225                1230        
Asn Thr Ser Lys His Thr Leu Tyr His Gly Arg Asp Thr Gln Tyr Tyr
        1235                1240                1245            
Phe Val Leu Pro Ala Gly Glu His Leu Asp Asn Tyr Lys Val Met Val
    1250                1255                1260                
Ser Thr Glu Ile Thr Asp Gly Lys Gly Ser Lys Val Gln Pro Cys Thr
1265                1270                1275                1280
Val Val Val Thr Val Leu Pro Arg Tyr His Gly Asn Asp Cys Leu Gly
                1285                1290                1295    
Glu Asp Leu Tyr Asn Ser Ser Leu Lys Asn Leu Ser Thr Leu Gln Leu
            1300                1305                1310        
Met Gly Ser Tyr Thr Glu Ile Arg Asn Tyr Ile Thr Val Ile Thr Arg
        1315                1320                1325            
Ile Leu Ser Arg Leu Ser Lys Glu Asp Lys Thr Ala Ser Cys Asn Gln
    1330                1335                1340                
Trp Ser Arg Ile Gln Asp Ala Leu Ile Ser Ser Val Cys Arg Leu Ala
1345                1350                1355                1360
Phe Val Asp Gln Glu Glu Met Ile Gly Ser Val Leu Met Leu Arg Asp
                1365                1370                1375    
Leu Val Ser Phe Ser Asn Lys Leu Gly Phe Met Ser Ala Val Leu Ile
            1380                1385                1390        
Leu Lys Tyr Thr Arg Ala Leu Leu Ala Gln Gly Gln Phe Ser Gly Pro
        1395                1400                1405            
Phe Val Ile Asp Lys Gly Val Arg Leu Glu Leu Ile Gly Leu Ile Ser
    1410                1415                1420                
Arg Val Trp Glu Val Ser Glu Gln Glu Asn Ser Lys Glu Glu Val Tyr
1425                1430                1435                1440
Arg His Glu Glu Gly Ile Thr Val Ile Ser Asp Leu Leu Leu Gly Cys
                1445                1450                1455    
Leu Ser Leu Asn His Val Ser Thr Gly Gln Met Glu Phe Arg Thr Leu
            1460                1465                1470        
Leu His Tyr Asn Leu Gln Ser Ser Val Gln Ser Leu Gly Ser Val Gln
        1475                1480                1485            
Val His Leu Pro Gly Asp Leu Ala Gly His Ser Pro Ala Gly Ala Glu
    1490                1495                1500                
Thr Gln Ser Pro Cys Tyr Ile Ser Gln Leu Ile Leu Phe Lys Lys Asn
1505                1510                1515                1520
Pro Tyr Pro Gly Ser Gln Ala Pro Gly Gln Ile Gly Gly Val Val Gly
                1525                1530                1535    
Leu Asn Leu Tyr Thr Cys Ser Ser Arg Arg Pro Ile Asn Arg Gln Trp
            1540                1545                1550        
Leu Arg Lys Pro Val Met Val Glu Phe Gly Glu Glu Asp Gly Leu Asp
        1555                1560                1565            
Asn Arg Arg Asn Lys Thr Thr Phe Val Leu Leu Arg Asp Lys Val Asn
    1570                1575                1580                
Leu His Gln Phe Thr Glu Leu Ser Glu Asn Pro Gln Glu Ser Leu Gln
1585                1590                1595                1600
Ile Glu Ile Glu Phe Ser Lys Pro Val Thr Arg Ala Phe Pro Val Met
                1605                1610                1615    
Leu Leu Val Arg Phe Ser Glu Lys Pro Thr Pro Ser Asp Phe Leu Val
            1620                1625                1630        
Lys Gln Ile Tyr Phe Trp Asp Glu Ser Ile Val Gln Ile Tyr Ile Pro
        1635                1640                1645            
Ala Ala Ser Gln Lys Asp Ala Ser Val Gly Tyr Leu Ser Leu Leu Asp
    1650                1655                1660                
Ala Asp Tyr Asp Arg Lys Pro Pro Asn Arg Tyr Leu Ala Lys Ala Val
1665                1670                1675                1680
Asn Tyr Thr Val His Phe Gln Trp Ile Arg Cys Leu Phe Trp Asp Lys
                1685                1690                1695    
Arg Glu Trp Lys Ser Glu Arg Phe Ser Pro Gln Pro Gly Thr Ser Pro
            1700                1705                1710        
Glu Lys Val Asn Cys Ser Tyr His Arg Leu Ala Ala Phe Ala Leu Leu
        1715                1720                1725            
Arg Arg Lys Leu Lys Ala Ser Phe Glu Val Ser Asp Ile Ser Lys Leu
    1730                1735                1740                
Gln Ser His Pro Glu Asn Leu Leu Pro Ser Ile Phe Ile Met Gly Ser
1745                1750                1755                1760
Val Ile Leu Tyr Gly Phe Leu Val Ala Lys Ser Arg Gln Val Asp His
                1765                1770                1775    
His Glu Lys Lys Lys Ala Gly Tyr Ile Phe Leu Gln Glu Ala Ser Leu
            1780                1785                1790        
Pro Gly His Gln Leu Tyr Ala Val Val Ile Asp Thr Gly Phe Arg Ala
        1795                1800                1805            
Pro Ala Arg Leu Thr Ser Lys Val Tyr Ile Val Leu Cys Gly Asp Asn
    1810                1815                1820                
Gly Leu Ser Glu Thr Lys Glu Leu Ser Cys Pro Glu Lys Pro Leu Phe
1825                1830                1835                1840
Glu Arg Asn Ser Arg His Thr Phe Ile Leu Ser Ala Pro Ala Gln Leu
                1845                1850                1855    
Gly Leu Leu Arg Lys Ile Arg Leu Trp His Asp Ser Arg Gly Pro Ser
            1860                1865                1870        
Pro Gly Trp Phe Ile Ser His Val Met Val Lys Glu Leu His Thr Gly
        1875                1880                1885            
Gln Gly Trp Phe Phe Pro Ala Gln Cys Trp Leu Ser Ala Gly Arg His
    1890                1895                1900                
Asp Gly Arg Val Glu Arg Glu Leu Thr Cys Leu Gln Gly Gly Leu Gly
1905                1910                1915                1920
Phe Arg Lys Leu Phe Tyr Cys Lys Phe Thr Glu Tyr Leu Glu Asp Phe
                1925                1930                1935    
His Val Trp Leu Ser Val Tyr Ser Arg Pro Ser Ser Ser Arg Tyr Leu
            1940                1945                1950        
His Thr Pro Arg Leu Thr Val Ser Phe Ser Leu Leu Cys Val Tyr Ala
        1955                1960                1965            
Cys Leu Thr Ala Leu Val Ala Ala Gly Gly Gln Glu Gln Pro His Leu
    1970                1975                1980                
Asp Val Ser Pro Thr Leu Gly Ser Phe Arg Val Gly Leu Leu Cys Thr
1985                1990                1995                2000
Leu Leu Ala Ser Pro Gly Ala Gln Leu Leu Ser Leu Leu Phe Arg Leu
                2005                2010                2015    
Ser Lys Glu Ala Pro Gly Ser Ala Arg Val Glu Pro His Ser Pro Leu
            2020                2025                2030        
Arg Gly Gly Ala Gln Thr Glu Ala Pro His Gly Pro Asn Ser Trp Gly
        2035                2040                2045            
Arg Ile Pro Asp Ala Gln Glu Pro Arg Lys Gln Pro Ala Ser Ala Ile
    2050                2055                2060                
Leu Ser Gly Ser Gly Arg Ala Gln Arg Lys Ala Ala Ser Asp Asn Gly
2065                2070                2075                2080
Thr Ala Cys Pro Ala Pro Lys Leu Gln Val His Gly Ala Asp His Ser
                2085                2090                2095    
Arg Thr Ser Leu Met Gly Lys Ser His Cys Cys Pro Pro His Thr Gln
            2100                2105                2110        
Ala Pro Ser Ser Gly Leu Glu Gly Leu Met Pro Gln Trp Ser Arg Ala
        2115                2120                2125            
Leu Gln Pro Trp Trp Ser Ser Ala Val Trp Ala Ile Cys Gly Thr Ala
    2130                2135                2140                
Ser Leu Ala Cys Ser Leu Gly Thr Gly Phe Leu Ala Tyr Arg Phe Gly
2145                2150                2155                2160
Gln Glu Gln Cys Val Gln Trp Leu His Leu Leu Ser Leu Ser Val Val
                2165                2170                2175    
Cys Cys Ile Phe Ile Thr Gln Pro Leu Met Val Cys Leu Met Ala Leu
            2180                2185                2190        
Gly Phe Ala Trp Lys Arg Arg Ala Asp Asn His Phe Phe Thr Glu Ser
        2195                2200                2205            
Leu Cys Glu Ala Thr Arg Asp Leu Asp Ser Glu Leu Ala Glu Arg Ser
    2210                2215                2220                
Trp Thr Arg Leu Pro Phe Ser Ser Ser Cys Ser Ile Pro Asp Cys Ala
2225                2230                2235                2240
Gly Glu Val Glu Lys Val Leu Ala Ala Arg Gln Gln Ala Arg His Leu
                2245                2250                2255    
Arg Trp Ala His Pro Pro Ser Lys Ala Gln Leu Arg Gly Thr Arg Gln
            2260                2265                2270        
Arg Met Arg Arg Glu Ser Arg Thr Arg Ala Ala Leu Arg Asp Ile Ser
        2275                2280                2285            
Met Asp Ile Leu Met Leu Leu Leu Leu Leu Cys Val Ile Tyr Gly Arg
    2290                2295                2300                
Phe Ser Gln Asp Glu Tyr Ser Leu Asn Gln Ala Ile Arg Lys Glu Phe
2305                2310                2315                2320
Thr Arg Asn Ala Arg Asn Cys Leu Gly Gly Leu Arg Asn Ile Ala Asp
                2325                2330                2335    
Trp Trp Asp Trp Ser Leu Thr Thr Leu Leu Asp Gly Leu Tyr Pro Gly
            2340                2345                2350        
Gly Thr Pro Ser Ala Arg Val Pro Gly Ala Gln Pro Gly Ala Leu Gly
        2355                2360                2365            
Gly Lys Cys Tyr Leu Ile Gly Ser Ser Val Ile Arg Gln Leu Lys Val
    2370                2375                2380                
Phe Pro Arg His Leu Cys Lys Pro Pro Arg Pro Phe Ser Ala Leu Ile
2385                2390                2395                2400
Glu Asp Ser Ile Pro Thr Cys Ser Pro Glu Val Gly Gly Pro Glu Asn
                2405                2410                2415    
Pro Tyr Leu Ile Asp Pro Glu Asn Gln Asn Val Thr Leu Asn Gly Pro
            2420                2425                2430        
Gly Gly Cys Gly Thr Arg Glu Asp Cys Val Leu Ser Leu Gly Arg Thr
        2435                2440                2445            
Arg Thr Glu Ala His Thr Ala Leu Ser Arg Leu Arg Ala Ser Met Trp
    2450                2455                2460                
Ile Asp Arg Ser Thr Arg Ala Val Ser Val His Phe Thr Leu Tyr Asn
2465                2470                2475                2480
Pro Pro Thr Gln Leu Phe Thr Ser Val Ser Leu Arg Val Glu Ile Leu
                2485                2490                2495    
Pro Thr Gly Ser Leu Val Pro Ser Ser Leu Val Glu Ser Phe Ser Ile
            2500                2505                2510        
Phe Arg Ser Asp Ser Ala Leu Gln Tyr His Leu Met Leu Pro Gln Leu
        2515                2520                2525            
Val Phe Leu Ala Leu Ser Leu Ile His Leu Cys Val Gln Leu Tyr Arg
    2530                2535                2540                
Met Met Asp Lys Gly Val Leu Ser Tyr Trp Arg Lys Pro Arg Asn Trp
2545                2550                2555                2560
Leu Glu Leu Ser Val Val Gly Val Ser Leu Thr Tyr Tyr Ala Val Ser
                2565                2570                2575    
Gly His Leu Val Thr Leu Ala Gly Asp Val Thr Asn Gln Phe His Arg
            2580                2585                2590        
Gly Leu Cys Arg Ala Phe Met Asp Leu Thr Leu Met Ala Ser Trp Asn
        2595                2600                2605            
Gln Arg Ala Arg Trp Leu Arg Gly Ile Leu Leu Phe Leu Phe Thr Leu
    2610                2615                2620                
Lys Cys Val Tyr Leu Pro Gly Ile Gln Asn Thr Met Ala Ser Cys Ser
2625                2630                2635                2640
Ser Met Met Arg His Ser Leu Pro Ser Ile Phe Val Ala Gly Leu Val
                2645                2650                2655    
Gly Ala Leu Met Leu Ala Ala Leu Ser His Leu His Arg Phe Leu Leu
            2660                2665                2670        
Ser Met Trp Val Leu Pro Pro Gly Thr Phe Thr Asp Ala Phe Pro Gly
        2675                2680                2685            
Leu Leu Phe His Phe Pro Arg Arg Ser Gln Lys Asp Cys Leu Leu Gly
    2690                2695                2700                
Leu Ser Lys Ser Asp Gln Arg Ala Met Ala Cys Tyr Phe Gly Ile Leu
2705                2710                2715                2720
Leu Ile Val Ser Ala Thr Leu Cys Phe Gly Met Leu Arg Gly Phe Leu
                2725                2730                2735    
Met Thr Leu Pro Gln Lys Arg Lys Ser Phe Gln Ser Lys Ser Phe Val
            2740                2745                2750        
Arg Leu Lys Asp Val Thr Ala Tyr Met Trp Glu Lys Val Leu Thr Phe
        2755                2760                2765            
Leu Arg Leu Glu Thr Pro Lys Leu Glu Glu Ala Glu Met Val Glu Asn
    2770                2775                2780                
His Asn Tyr Tyr Leu Asp Glu Phe Ala Asn Leu Leu Asp Glu Leu Leu
2785                2790                2795                2800
Met Lys Ile Asn Gly Leu Ser Asp Ser Leu Gln Leu Pro Leu Leu Glu
                2805                2810                2815    
Lys Thr Ser Asn Asn Thr Gly Glu Ala Arg Thr Glu Glu Ser Pro Leu
            2820                2825                2830        
Val Asp Ile Ser Ser Tyr Gln Ala Ala Glu Pro Ala Asp Ile Lys Asp
        2835                2840                2845            
Phe
    


<210> 9426
<211> 421
<212> PRT
<213> Homo sapiens

<400> 9426
Val Gly Asn Lys Lys Thr His Ile Asn Ile Val Val Ile Gly His Val
 1               5                  10                  15      
Asp Leu Gly Lys Tyr Thr Ala Thr Gly His Leu Thr Tyr Lys Cys Gly
            20                  25                  30          
Gly Ile Asn Glu Arg Thr Ile Glu Asn Ile Glu Asn Glu Ala Thr Glu
        35                  40                  45              
Met Arg Lys Asn Ser Phe Lys Tyr Ala Trp Val Ser Leu Asn Lys Leu
    50                  55                  60                  
Ser Ser Glu Cys Glu Cys Ser Ile Ile Ile Gly Ile Ala Leu Trp Lys
65                  70                  75                  80  
Phe Glu Ile Ser Arg Tyr Tyr Val Thr Ile Ile Asp Asp Pro Arg His
                85                  90                  95      
Ser Tyr Phe Ile Lys Asn Leu Ile Ala Gly Ile Ser His Thr Gly Leu
            100                 105                 110         
Ser Gly Leu Leu Leu Leu Ala Leu Val Ile Phe Lys Leu Cys Phe Pro
        115                 120                 125             
Arg Val Asp Thr His Glu His Ala Ser Leu Ala His Thr Pro Gly Met
    130                 135                 140                 
Lys Gln Leu Ile Val Gly Val Asn Lys Ser Arg Ile His Arg Phe His
145                 150                 155                 160 
Pro Thr Thr Arg Arg Asp Met Asn Lys Leu Leu Arg Lys Ser Ala Leu
                165                 170                 175     
Thr Leu Arg Lys Leu Thr Tyr Tyr Arg His Lys Val Ala Phe Val Pro
            180                 185                 190         
Ile Phe Gly Trp Asp Gly Glu Pro Ser Ala Cys Met Leu Trp Phe Lys
        195                 200                 205             
Ala Trp Lys Val Ile Asp Lys Asp Ser Asn Ala Gly Gly Thr Met Leu
    210                 215                 220                 
Pro Glu Gly Leu Val Cys Lys Leu Pro Pro Thr His Pro Ala Asp Lys
225                 230                 235                 240 
Pro Leu His Leu Pro Phe Gln Asp Val Tyr Lys Met Ile Gly Thr Ile
                245                 250                 255     
Pro Val Gly Gln Val Glu Ser Gly Val Leu Lys Leu Ala Trp Trp Ser
            260                 265                 270         
Pro Phe Phe Glu Ser Val Thr Thr Glu Val Lys Ser Val Gly Arg Tyr
        275                 280                 285             
His Glu Ala Leu Ser Glu Ala Leu Pro Lys Asn Asn Val Gly Phe Ser
    290                 295                 300                 
Phe Asn Asn Val Pro Val Lys His Val Arg Cys Gly Asn Val Ala Gly
305                 310                 315                 320 
Asp Ser Lys Tyr Asp Pro Pro Met Glu Ala Ser Gly Phe Thr Ala Gln
                325                 330                 335     
Met Ile Ile Arg Lys Arg Ile Ser Val Ser Tyr Thr Pro Val Leu Asn
            340                 345                 350         
Cys His Thr Ala His Ile Ala Gly Lys Phe Ala Ala Leu Lys Glu Lys
        355                 360                 365             
Ile Glu His Cys Ser Gly Lys Lys Leu Glu Asn Asp Pro Glu Phe Leu
    370                 375                 380                 
Lys Phe Gly Asp Ala Ser Ile Ile Asp Lys Ile Pro Ser Lys Cys Met
385                 390                 395                 400 
Cys Val Glu Thr Phe Ser Asn Tyr Ser Leu Leu Gly His Phe Ala Val
                405                 410                 415     
Arg His Met Lys Gln
            420     


<210> 9427
<211> 380
<212> PRT
<213> Homo sapiens

<400> 9427
Met Cys Pro Met Leu Leu Lys Asn Gly Tyr Asn Gly Asn Ala Thr Pro
 1               5                  10                  15      
Val Thr Thr Thr Ala Pro Trp Ala Ser Leu Gly Leu Ser Ala Lys Thr
            20                  25                  30          
Cys Asn Asn Val Ser Phe Glu Glu Ser Arg Ile Val Leu Val Val Val
        35                  40                  45              
Tyr Ser Ala Val Cys Thr Leu Gly Val Pro Ala Asn Cys Leu Thr Ala
    50                  55                  60                  
Trp Leu Ala Leu Leu Gln Val Leu Gln Gly Asn Val Leu Ala Val Tyr
65                  70                  75                  80  
Leu Leu Cys Leu Ala Leu Cys Glu Leu Leu Tyr Thr Gly Thr Leu Pro
                85                  90                  95      
Leu Trp Val Ile Tyr Ile Arg Asn Gln His Arg Trp Thr Leu Gly Leu
            100                 105                 110         
Leu Ala Cys Lys Val Thr Ala Tyr Ile Phe Phe Cys Asn Ile Tyr Val
        115                 120                 125             
Ser Ile Leu Phe Leu Cys Cys Ile Ser Cys Asp Arg Phe Val Ala Val
    130                 135                 140                 
Val Tyr Ala Leu Glu Ser Arg Gly Arg Arg Arg Arg Arg Thr Ala Ile
145                 150                 155                 160 
Leu Ile Ser Ala Cys Ile Phe Ile Leu Val Gly Ile Val His Tyr Pro
                165                 170                 175     
Val Phe Gln Thr Glu Asp Lys Glu Thr Cys Phe Asp Met Leu Gln Met
            180                 185                 190         
Asp Ser Arg Ile Ala Gly Tyr Tyr Tyr Ala Arg Phe Thr Val Gly Phe
        195                 200                 205             
Ala Ile Pro Leu Ser Ile Ile Ala Phe Thr Asn His Arg Ile Phe Arg
    210                 215                 220                 
Ser Ile Lys Gln Ser Met Gly Leu Ser Ala Ala Gln Lys Ala Lys Val
225                 230                 235                 240 
Lys His Ser Ala Ile Ala Val Val Val Ile Phe Leu Val Cys Phe Ala
                245                 250                 255     
Pro Tyr His Leu Val Leu Leu Val Lys Ala Ala Ala Phe Ser Tyr Tyr
            260                 265                 270         
Arg Gly Asp Arg Asn Ala Met Cys Gly Leu Glu Glu Arg Leu Tyr Thr
        275                 280                 285             
Ala Ser Val Val Phe Leu Cys Leu Ser Thr Val Asn Gly Val Ala Asp
    290                 295                 300                 
Pro Ile Ile Tyr Val Leu Ala Thr Asp His Ser Arg Gln Glu Val Ser
305                 310                 315                 320 
Arg Ile His Lys Gly Trp Lys Glu Trp Ser Met Lys Thr Asp Val Thr
                325                 330                 335     
Arg Leu Thr His Ser Arg Asp Thr Glu Glu Leu Gln Ser Pro Val Ala
            340                 345                 350         
Leu Ala Asp His Tyr Thr Phe Ser Arg Pro Val His Pro Pro Gly Ser
        355                 360                 365             
Pro Cys Pro Ala Lys Arg Leu Ile Glu Glu Ser Cys
    370                 375                 380 


<210> 9428
<211> 799
<212> PRT
<213> Homo sapiens

<400> 9428
Met Pro Glu Arg Leu Ala Glu Met Leu Leu Asp Leu Trp Thr Pro Leu
 1               5                  10                  15      
Ile Ile Leu Trp Ile Thr Leu Pro Pro Cys Ile Tyr Met Ala Pro Met
            20                  25                  30          
Asn Gln Ser Gln Val Leu Met Ser Gly Ser Pro Leu Glu Leu Asn Ser
        35                  40                  45              
Leu Gly Glu Glu Gln Arg Ile Leu Asn Arg Ser Lys Arg Gly Trp Val
    50                  55                  60                  
Trp Asn Gln Met Phe Val Leu Glu Glu Phe Ser Gly Pro Glu Pro Ile
65                  70                  75                  80  
Leu Val Gly Arg Leu His Thr Asp Leu Asp Pro Gly Ser Lys Lys Ile
                85                  90                  95      
Lys Tyr Ile Leu Ser Gly Asp Gly Ala Gly Thr Ile Phe Gln Ile Asn
            100                 105                 110         
Asp Val Thr Gly Asp Ile His Ala Ile Lys Arg Leu Asp Arg Glu Glu
        115                 120                 125             
Lys Ala Glu Tyr Thr Leu Thr Ala Gln Ala Val Asp Trp Glu Thr Ser
    130                 135                 140                 
Lys Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile
145                 150                 155                 160 
Asn Asp Asn Ala Pro Glu Phe Leu Asn Gly Pro Tyr His Ala Thr Val
                165                 170                 175     
Pro Glu Met Ser Ile Leu Gly Thr Ser Val Thr Asn Val Thr Ala Thr
            180                 185                 190         
Asp Ala Asp Asp Pro Val Tyr Gly Asn Ser Ala Lys Leu Val Tyr Ser
        195                 200                 205             
Ile Leu Glu Gly Gln Pro Tyr Phe Ser Ile Glu Pro Glu Thr Ala Ile
    210                 215                 220                 
Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Glu Glu Tyr
225                 230                 235                 240 
Leu Val Val Ile Gln Ala Lys Asp Met Gly Gly His Ser Gly Gly Leu
                245                 250                 255     
Ser Gly Thr Thr Thr Leu Thr Val Thr Leu Thr Asp Val Asn Asp Asn
            260                 265                 270         
Pro Pro Lys Phe Ala Gln Ser Leu Tyr His Phe Ser Val Pro Glu Asp
        275                 280                 285             
Val Val Leu Gly Thr Ala Ile Gly Arg Val Lys Ala Asn Asp Gln Asp
    290                 295                 300                 
Ile Gly Glu Asn Ala Gln Ser Ser Tyr Asp Ile Ile Asp Gly Asp Gly
305                 310                 315                 320 
Thr Ala Leu Phe Glu Ile Thr Ser Asp Ala Gln Ala Gln Asp Gly Ile
                325                 330                 335     
Ile Arg Leu Arg Lys Pro Leu Asp Phe Glu Thr Lys Lys Ser Tyr Thr
            340                 345                 350         
Leu Lys Val Glu Ala Ala Asn Val His Ile Asp Pro Arg Phe Ser Gly
        355                 360                 365             
Arg Gly Pro Phe Lys Asp Thr Ala Thr Val Lys Ile Val Val Glu Asp
    370                 375                 380                 
Ala Asp Glu Pro Pro Val Phe Ser Ser Pro Thr Tyr Leu Leu Glu Val
385                 390                 395                 400 
His Glu Asn Ala Ala Leu Asn Ser Val Ile Gly Gln Val Thr Ala Arg
                405                 410                 415     
Asp Pro Asp Ile Thr Ser Ser Pro Ile Arg Phe Ser Ile Asp Arg His
            420                 425                 430         
Thr Asp Leu Glu Arg Gln Phe Asn Ile Asn Ala Asp Asp Gly Lys Ile
        435                 440                 445             
Thr Leu Ala Thr Pro Leu Asp Arg Glu Leu Ser Val Trp His Asn Ile
    450                 455                 460                 
Thr Ile Ile Ala Thr Glu Ile Arg Asn His Ser Gln Ile Ser Arg Val
465                 470                 475                 480 
Pro Val Ala Ile Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe
                485                 490                 495     
Ala Ser Glu Tyr Glu Ala Phe Leu Cys Glu Asn Gly Lys Pro Gly Gln
            500                 505                 510         
Val Ile Gln Thr Val Ser Ala Met Asp Lys Asp Asp Pro Lys Asn Gly
        515                 520                 525             
His Tyr Phe Leu Tyr Ser Leu Leu Pro Glu Met Val Asn Asn Pro Asn
    530                 535                 540                 
Phe Thr Ile Lys Lys Asn Glu Asp Asn Ser Leu Ser Ile Leu Ala Lys
545                 550                 555                 560 
His Asn Gly Phe Asn Arg Gln Lys Gln Glu Val Tyr Leu Leu Pro Ile
                565                 570                 575     
Ile Ile Ser Asp Ser Gly Asn Pro Pro Leu Ser Ser Thr Ser Thr Leu
            580                 585                 590         
Thr Ile Arg Val Cys Gly Cys Ser Asn Asp Gly Val Val Gln Ser Cys
        595                 600                 605             
Asn Val Glu Ala Tyr Val Leu Pro Ile Gly Leu Ser Met Gly Ala Leu
    610                 615                 620                 
Ile Ala Ile Leu Ala Cys Ile Ile Leu Leu Leu Val Ile Val Val Leu
625                 630                 635                 640 
Phe Val Thr Leu Arg Arg His Lys Asn Glu Pro Leu Ile Ile Lys Asp
                645                 650                 655     
Asp Glu Asp Val Arg Glu Asn Ile Ile Arg Tyr Asp Asp Glu Gly Gly
            660                 665                 670         
Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro
        675                 680                 685             
Asp Gly Ile Asn Gly Phe Leu Pro Arg Lys Asp Ile Lys Pro Asp Leu
    690                 695                 700                 
Gln Phe Met Pro Arg Gln Gly Leu Ala Pro Val Pro Asn Gly Val Asp
705                 710                 715                 720 
Val Asp Glu Phe Ile Asn Val Arg Leu His Glu Ala Asp Asn Asp Pro
                725                 730                 735     
Thr Ala Pro Pro Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg
            740                 745                 750         
Gly Ser Val Ala Gly Ser Leu Ser Ser Leu Glu Ser Thr Thr Ser Asp
        755                 760                 765             
Ser Asp Gln Asn Phe Asp Tyr Leu Ser Asp Trp Gly Pro Arg Phe Lys
    770                 775                 780                 
Arg Leu Gly Glu Leu Tyr Ser Val Gly Glu Ser Asp Lys Glu Thr
785                 790                 795                 


<210> 9429
<211> 347
<212> PRT
<213> Homo sapiens

<400> 9429
Met Asn Pro Leu Ala Gln Pro Val Ile Tyr Ser Thr Ile Phe Ala Gly
 1               5                  10                  15      
Thr Leu Ile Thr Ala Leu Ser Ser His Trp Phe Phe Thr Trp Val Gly
            20                  25                  30          
Leu Glu Met Asn Met Leu Ala Phe Ile Pro Val Leu Thr Lys Lys Met
        35                  40                  45              
Asn Pro Arg Ser Thr Glu Ala Ala Ile Lys Tyr Phe Leu Thr Gln Ala
    50                  55                  60                  
Thr Ala Ser Met Ile Leu Leu Met Ala Ile Leu Phe Asn Asn Met Leu
65                  70                  75                  80  
Ser Gly Gln Trp Thr Met Thr Asn Thr Thr Asn Gln Tyr Ser Ser Leu
                85                  90                  95      
Met Ile Met Met Ala Met Ala Met Lys Leu Gly Met Ala Pro Phe His
            100                 105                 110         
Phe Trp Val Pro Glu Val Thr Gln Gly Thr Pro Leu Thr Ser Gly Leu
        115                 120                 125             
Leu Leu Leu Thr Trp Gln Lys Leu Ala Pro Ile Ser Ile Met Tyr Gln
    130                 135                 140                 
Ile Ser Pro Ser Leu Asn Val Ser Leu Leu Leu Thr Leu Ser Ile Leu
145                 150                 155                 160 
Ser Ile Met Ala Gly Ser Trp Gly Gly Leu Asn Gln Thr Gln Leu Arg
                165                 170                 175     
Lys Ile Leu Ala Tyr Ser Ser Ile Thr His Met Gly Trp Met Met Ala
            180                 185                 190         
Val Leu Pro Tyr Asn Pro Asn Met Thr Ile Leu Asn Leu Thr Ile Tyr
        195                 200                 205             
Ile Ile Leu Thr Thr Thr Ala Phe Leu Leu Leu Asn Leu Asn Ser Ser
    210                 215                 220                 
Thr Thr Thr Leu Leu Leu Ser Arg Thr Trp Asn Lys Leu Thr Trp Leu
225                 230                 235                 240 
Thr Pro Leu Ile Pro Ser Thr Leu Leu Ser Leu Gly Gly Leu Pro Pro
                245                 250                 255     
Leu Thr Gly Phe Leu Pro Lys Trp Ala Ile Ile Glu Glu Phe Thr Lys
            260                 265                 270         
Asn Asn Ser Leu Ile Ile Pro Thr Ile Met Ala Thr Ile Thr Leu Leu
        275                 280                 285             
Asn Leu Tyr Phe Tyr Leu Arg Leu Ile Tyr Ser Thr Ser Ile Thr Leu
    290                 295                 300                 
Leu Pro Met Ser Asn Asn Val Lys Met Lys Trp Gln Phe Glu His Thr
305                 310                 315                 320 
Lys Pro Thr Pro Phe Leu Pro Thr Leu Ile Ala Leu Thr Thr Leu Leu
                325                 330                 335     
Leu Pro Ile Ser Pro Phe Met Leu Met Ile Leu
            340                 345         


<210> 9430
<211> 466
<212> PRT
<213> Homo sapiens

<400> 9430
Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser
 1               5                  10                  15      
Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser
            20                  25                  30          
Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile
        35                  40                  45              
Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser
    50                  55                  60                  
Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr
65                  70                  75                  80  
Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys
                85                  90                  95      
Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met
            100                 105                 110         
Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro
        115                 120                 125             
Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile
    130                 135                 140                 
Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu
145                 150                 155                 160 
Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys
                165                 170                 175     
Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile
            180                 185                 190         
Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His
        195                 200                 205             
Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro
    210                 215                 220                 
Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile
225                 230                 235                 240 
Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu
                245                 250                 255     
His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu
            260                 265                 270         
Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser
        275                 280                 285             
Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp
    290                 295                 300                 
Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser
305                 310                 315                 320 
Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser
                325                 330                 335     
Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln
            340                 345                 350         
Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met
        355                 360                 365             
Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys
    370                 375                 380                 
Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp
385                 390                 395                 400 
Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys
                405                 410                 415     
Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn
            420                 425                 430         
Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys
        435                 440                 445             
Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala
    450                 455                 460                 
Thr Arg
465     


<210> 9431
<211> 775
<212> PRT
<213> Homo sapiens

<400> 9431
Met Glu Pro Pro Tyr Ser Leu Thr Ala His Tyr Asp Glu Phe Gln Glu
 1               5                  10                  15      
Val Lys Tyr Val Ser Arg Cys Gly Ala Gly Gly Ala Arg Gly Ala Ser
            20                  25                  30          
Leu Pro Pro Gly Phe Pro Leu Gly Ala Ala Arg Ser Ala Thr Gly Ala
        35                  40                  45              
Arg Ser Gly Leu Pro Arg Trp Asn Arg Arg Glu Val Cys Leu Leu Ser
    50                  55                  60                  
Gly Leu Val Phe Ala Ala Gly Leu Cys Ala Ile Leu Ala Ala Met Leu
65                  70                  75                  80  
Ala Leu Lys Tyr Leu Gly Pro Val Ala Ala Gly Gly Gly Ala Cys Pro
                85                  90                  95      
Glu Gly Cys Pro Glu Arg Lys Ala Phe Ala Arg Ala Ala Arg Phe Leu
            100                 105                 110         
Ala Ala Asn Leu Asp Ala Ser Ile Asp Pro Cys Gln Asp Phe Tyr Ser
        115                 120                 125             
Phe Ala Cys Gly Gly Trp Leu Arg Arg His Ala Ile Pro Asp Asp Lys
    130                 135                 140                 
Leu Thr Tyr Gly Thr Ile Ala Ala Ile Gly Glu Gln Asn Glu Glu Arg
145                 150                 155                 160 
Leu Arg Arg Leu Leu Ala Arg Pro Gly Gly Gly Pro Gly Gly Ala Ala
                165                 170                 175     
Gln Arg Lys Val Arg Ala Phe Phe Arg Ser Cys Leu Asp Met Arg Glu
            180                 185                 190         
Ile Glu Arg Leu Gly Pro Arg Pro Met Leu Glu Val Ile Glu Asp Cys
        195                 200                 205             
Gly Gly Trp Asp Leu Gly Gly Ala Glu Glu Arg Pro Gly Val Ala Ala
    210                 215                 220                 
Arg Trp Asp Leu Asn Arg Leu Leu Tyr Lys Ala Gln Gly Val Tyr Ser
225                 230                 235                 240 
Ala Ala Ala Leu Phe Ser Leu Thr Val Ser Leu Asp Asp Arg Asn Ser
                245                 250                 255     
Ser Arg Tyr Val Ile Arg Ile Asp Gln Asp Gly Leu Thr Leu Pro Glu
            260                 265                 270         
Arg Thr Leu Tyr Leu Ala Gln Asp Glu Asp Ser Glu Lys Val Leu Ala
        275                 280                 285             
Ala Tyr Arg Val Phe Met Glu Arg Val Leu Ser Leu Leu Gly Ala Asp
    290                 295                 300                 
Ala Val Glu Gln Lys Ala Gln Glu Ile Leu Gln Val Glu Gln Gln Leu
305                 310                 315                 320 
Ala Asn Ile Thr Val Ser Glu Tyr Asp Asp Leu Arg Arg Asp Val Ser
                325                 330                 335     
Ser Met Tyr Asn Lys Val Thr Leu Gly Gln Leu Gln Lys Ile Thr Pro
            340                 345                 350         
His Leu Arg Trp Lys Trp Leu Leu Asp Gln Ile Phe Gln Glu Asp Phe
        355                 360                 365             
Ser Glu Glu Glu Glu Val Val Leu Leu Ala Thr Asp Tyr Met Gln Gln
    370                 375                 380                 
Val Ser Gln Leu Ile Arg Ser Thr Pro His Arg Val Leu His Asn Tyr
385                 390                 395                 400 
Leu Val Trp Arg Val Val Val Val Leu Ser Glu His Leu Ser Pro Pro
                405                 410                 415     
Phe Arg Glu Ala Leu His Glu Leu Ala Gln Glu Met Glu Gly Ser Asp
            420                 425                 430         
Lys Pro Gln Glu Leu Ala Arg Val Cys Leu Gly Gln Ala Asn Arg His
        435                 440                 445             
Phe Gly Met Ala Leu Gly Ala Leu Phe Val His Glu His Phe Ser Ala
    450                 455                 460                 
Ala Ser Lys Ala Lys Val Gln Gln Leu Val Glu Asp Ile Lys Tyr Ile
465                 470                 475                 480 
Leu Gly Gln Arg Leu Glu Glu Leu Asp Trp Met Asp Ala Glu Thr Arg
                485                 490                 495     
Ala Ala Ala Arg Ala Lys Leu Gln Tyr Met Met Val Met Val Gly Tyr
            500                 505                 510         
Pro Asp Phe Leu Leu Lys Pro Asp Ala Val Asp Lys Glu Tyr Glu Phe
        515                 520                 525             
Glu Val His Glu Lys Thr Tyr Phe Lys Asn Ile Leu Asn Ser Ile Arg
    530                 535                 540                 
Phe Ser Ile Gln Leu Ser Val Lys Lys Ile Arg Gln Glu Val Asp Lys
545                 550                 555                 560 
Ser Thr Trp Leu Leu Pro Pro Gln Ala Leu Asn Ala Tyr Tyr Leu Pro
                565                 570                 575     
Asn Lys Asn Gln Met Val Phe Pro Ala Gly Ile Leu Gln Pro Thr Leu
            580                 585                 590         
Tyr Asp Pro Asp Phe Pro Gln Ser Leu Asn Tyr Gly Gly Ile Gly Thr
        595                 600                 605             
Ile Ile Gly His Glu Leu Thr His Gly Tyr Asp Asp Trp Gly Gly Gln
    610                 615                 620                 
Tyr Asp Arg Ser Gly Asn Leu Leu His Trp Trp Thr Glu Ala Ser Tyr
625                 630                 635                 640 
Ser Arg Phe Leu Arg Lys Ala Glu Cys Ile Val Arg Leu Tyr Asp Asn
                645                 650                 655     
Phe Thr Val Tyr Asn Gln Arg Val Asn Gly Lys His Thr Leu Gly Glu
            660                 665                 670         
Asn Ile Ala Asp Met Gly Gly Leu Lys Leu Ala Tyr His Ala Tyr Gln
        675                 680                 685             
Lys Trp Val Arg Glu His Gly Pro Glu His Pro Leu Pro Arg Leu Lys
    690                 695                 700                 
Tyr Thr His Asp Gln Leu Phe Phe Ile Ala Phe Ala Gln Asn Trp Cys
705                 710                 715                 720 
Ile Lys Arg Arg Ser Gln Ser Ile Tyr Leu Gln Val Leu Thr Asp Lys
                725                 730                 735     
His Ala Pro Glu His Tyr Arg Val Leu Gly Ser Val Ser Gln Phe Glu
            740                 745                 750         
Glu Phe Gly Arg Val Leu His Cys Pro Lys Val Ser Pro Met Asn Pro
        755                 760                 765             
Ala His Lys Cys Ser Val Trp
    770                 775 


<210> 9432
<211> 402
<212> PRT
<213> Homo sapiens

<400> 9432
Met Met Gly Ser Trp Lys His Cys Leu Phe Ser Ala Ser Leu Ile Ser
 1               5                  10                  15      
Ala Leu Ile Phe Val Phe Val Tyr Asn Thr Glu Leu Trp Glu Asn Lys
            20                  25                  30          
Arg Phe Leu Arg Ala Ala Leu Ser Asn Ala Ser Leu Leu Ala Glu Ala
        35                  40                  45              
Cys His Gln Ile Phe Glu Gly Lys Val Phe Tyr Pro Thr Glu Asn Ala
    50                  55                  60                  
Leu Lys Thr Thr Leu Asp Glu Ala Thr Cys Tyr Glu Tyr Met Val Arg
65                  70                  75                  80  
Ser His Tyr Val Thr Glu Thr Leu Ser Glu Glu Glu Ala Gly Phe Pro
                85                  90                  95      
Leu Ala Tyr Thr Val Thr Ile His Lys Asp Phe Gly Thr Phe Glu Arg
            100                 105                 110         
Leu Phe Arg Ala Ile Tyr Met Pro Gln Asn Val Tyr Cys Val His Leu
        115                 120                 125             
Asp Gln Lys Ala Thr Asp Ala Phe Lys Gly Ala Val Lys Gln Leu Leu
    130                 135                 140                 
Ser Cys Phe Pro Asn Ala Phe Leu Ala Ser Lys Lys Glu Ser Val Val
145                 150                 155                 160 
Tyr Gly Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Leu Glu Asp
                165                 170                 175     
Leu Val Ala Ser Glu Val Pro Trp Lys Tyr Val Ile Asn Thr Cys Gly
            180                 185                 190         
Gln Asp Phe Pro Leu Lys Thr Asn Arg Glu Ile Val Gln Tyr Leu Lys
        195                 200                 205             
Gly Phe Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Asp His
    210                 215                 220                 
Ala Val Gly Arg Thr Lys Tyr Val His Gln Glu Leu Leu Asn His Lys
225                 230                 235                 240 
Asn Ser Tyr Val Ile Lys Thr Thr Lys Leu Lys Thr Pro Pro Pro His
                245                 250                 255     
Asp Met Val Ile Tyr Phe Gly Thr Ala Tyr Val Ala Leu Thr Arg Asp
            260                 265                 270         
Phe Ala Asn Phe Val Leu Gln Asp Gln Leu Ala Leu Asp Leu Leu Ser
        275                 280                 285             
Trp Ser Lys Asp Thr Tyr Ser Pro Asp Glu His Phe Trp Val Thr Leu
    290                 295                 300                 
Asn Arg Ile Pro Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp Thr
305                 310                 315                 320 
Gly Asn Leu Arg Ala Ile Lys Trp Ser Asp Met Glu Asp Arg His Gly
                325                 330                 335     
Gly Cys His Gly His Tyr Val His Gly Ile Cys Ile Tyr Gly Asn Gly
            340                 345                 350         
Asp Leu Lys Trp Leu Val Asn Ser Pro Ser Leu Phe Ala Asn Lys Phe
        355                 360                 365             
Glu Leu Asn Thr Tyr Pro Leu Thr Val Glu Cys Leu Glu Leu Arg His
    370                 375                 380                 
Arg Glu Arg Thr Leu Asn Gln Ser Glu Thr Ala Ile Gln Pro Ser Trp
385                 390                 395                 400 
Tyr Phe
        


<210> 9433
<211> 400
<212> PRT
<213> Homo sapiens

<400> 9433
Met Pro Leu Ser Met Arg Tyr Leu Phe Ile Ile Ser Val Ser Ser Val
 1               5                  10                  15      
Ile Ile Phe Ile Val Phe Ser Val Phe Asn Phe Gly Gly Asp Pro Ser
            20                  25                  30          
Phe Gln Arg Leu Asn Ile Ser Asp Pro Leu Arg Leu Thr Gln Val Cys
        35                  40                  45              
Thr Ser Phe Ile Asn Gly Lys Thr Arg Phe Leu Trp Lys Asn Lys Leu
    50                  55                  60                  
Met Ile His Glu Lys Ser Ser Cys Lys Glu Tyr Leu Thr Gln Ser His
65                  70                  75                  80  
Tyr Ile Thr Ala Pro Leu Ser Lys Glu Glu Ala Asp Phe Pro Leu Ala
                85                  90                  95      
Tyr Ile Met Val Ile His His His Phe Asp Thr Phe Ala Arg Leu Phe
            100                 105                 110         
Arg Ala Ile Tyr Met Pro Gln Asn Ile Tyr Cys Val His Val Asp Glu
        115                 120                 125             
Lys Ala Thr Thr Glu Phe Lys Asp Ala Val Glu Gln Leu Leu Ser Cys
    130                 135                 140                 
Phe Pro Asn Ala Phe Leu Ala Ser Lys Met Glu Pro Val Val Tyr Gly
145                 150                 155                 160 
Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Ile Arg Asp Leu Ser
                165                 170                 175     
Ala Phe Glu Val Ser Trp Lys Tyr Val Ile Asn Thr Cys Gly Gln Asp
            180                 185                 190         
Phe Pro Leu Lys Thr Asn Lys Glu Ile Val Gln Tyr Leu Lys Gly Phe
        195                 200                 205             
Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Ala His Ala Ile
    210                 215                 220                 
Gly Arg Thr Lys Tyr Val His Gln Glu His Leu Gly Lys Glu Leu Ser
225                 230                 235                 240 
Tyr Val Ile Arg Thr Thr Ala Leu Lys Pro Pro Pro Pro His Asn Leu
                245                 250                 255     
Thr Ile Tyr Phe Gly Ser Ala Tyr Val Ala Leu Ser Arg Glu Phe Ala
            260                 265                 270         
Asn Phe Val Leu His Asp Pro Arg Ala Val Asp Leu Leu Gln Trp Ser
        275                 280                 285             
Lys Asp Thr Phe Ser Pro Asp Glu His Phe Trp Val Thr Leu Asn Arg
    290                 295                 300                 
Ile Pro Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp Thr Gly Asn
305                 310                 315                 320 
Leu Arg Ala Ile Lys Trp Ser Asp Met Glu Asp Arg His Gly Gly Cys
                325                 330                 335     
His Gly His Tyr Val His Gly Ile Cys Ile Tyr Gly Asn Gly Asp Leu
            340                 345                 350         
Lys Trp Leu Val Asn Ser Pro Ser Leu Phe Ala Asn Lys Phe Glu Leu
        355                 360                 365             
Asn Thr Tyr Pro Leu Thr Val Glu Cys Leu Glu Leu Arg His Arg Glu
    370                 375                 380                 
Arg Thr Leu Asn Gln Ser Glu Thr Ala Ile Gln Pro Ser Trp Tyr Phe
385                 390                 395                 400 


<210> 9434
<211> 839
<212> PRT
<213> Homo sapiens

<400> 9434
Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe
 1               5                  10                  15      
Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys
            20                  25                  30          
Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro
        35                  40                  45              
Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn
    50                  55                  60                  
Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile
65                  70                  75                  80  
Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala
                85                  90                  95      
Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn
            100                 105                 110         
Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His
        115                 120                 125             
Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp
    130                 135                 140                 
Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn
145                 150                 155                 160 
Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu
                165                 170                 175     
Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala
            180                 185                 190         
Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp
        195                 200                 205             
Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly
    210                 215                 220                 
Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp
225                 230                 235                 240 
Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr
                245                 250                 255     
Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn
            260                 265                 270         
Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn
        275                 280                 285             
Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro
    290                 295                 300                 
Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys
305                 310                 315                 320 
Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu
                325                 330                 335     
His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr
            340                 345                 350         
Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro
        355                 360                 365             
Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu
    370                 375                 380                 
Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe
385                 390                 395                 400 
Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr
                405                 410                 415     
Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val
            420                 425                 430         
Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val
        435                 440                 445             
Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met
    450                 455                 460                 
Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro
465                 470                 475                 480 
Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala
                485                 490                 495     
Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu
            500                 505                 510         
Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr
        515                 520                 525             
Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu
    530                 535                 540                 
Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu
545                 550                 555                 560 
Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp
                565                 570                 575     
Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu
            580                 585                 590         
Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly
        595                 600                 605             
Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp
    610                 615                 620                 
Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val
625                 630                 635                 640 
Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met
                645                 650                 655     
Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser
            660                 665                 670         
Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly
        675                 680                 685             
Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val
    690                 695                 700                 
Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe
705                 710                 715                 720 
Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp
                725                 730                 735     
Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp
            740                 745                 750         
Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys
        755                 760                 765             
Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr
    770                 775                 780                 
Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr
785                 790                 795                 800 
Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn
                805                 810                 815     
Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro
            820                 825                 830         
Ile Tyr Leu Asp Ile Leu Gly
        835                 


<210> 9435
<211> 612
<212> PRT
<213> Homo sapiens

<400> 9435
Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe
 1               5                  10                  15      
Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys
            20                  25                  30          
Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro
        35                  40                  45              
Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn
    50                  55                  60                  
Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile
65                  70                  75                  80  
Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala
                85                  90                  95      
Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn
            100                 105                 110         
Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His
        115                 120                 125             
Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp
    130                 135                 140                 
Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn
145                 150                 155                 160 
Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu
                165                 170                 175     
Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala
            180                 185                 190         
Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp
        195                 200                 205             
Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly
    210                 215                 220                 
Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp
225                 230                 235                 240 
Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr
                245                 250                 255     
Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn
            260                 265                 270         
Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn
        275                 280                 285             
Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro
    290                 295                 300                 
Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys
305                 310                 315                 320 
Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu
                325                 330                 335     
His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr
            340                 345                 350         
Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro
        355                 360                 365             
Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu
    370                 375                 380                 
Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe
385                 390                 395                 400 
Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr
                405                 410                 415     
Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val
            420                 425                 430         
Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val
        435                 440                 445             
Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met
    450                 455                 460                 
Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro
465                 470                 475                 480 
Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala
                485                 490                 495     
Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu
            500                 505                 510         
Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr
        515                 520                 525             
Trp Val Phe Ser Asn Ile Asp Asn His Gly Ile Leu Asn Leu Lys Asp
    530                 535                 540                 
Asn Arg Asp His Leu Val Pro Ser Thr His Tyr Ile Tyr Glu Glu Pro
545                 550                 555                 560 
Glu Val Gln Ser Gly Glu Val Ser Tyr Pro Arg Ser His Gly Phe Arg
                565                 570                 575     
Glu Ile Met Leu Asn Pro Ile Ser Leu Pro Gly His Ser Lys Pro Leu
            580                 585                 590         
Asn His Gly Ile Tyr Val Glu Asp Val Asn Val Tyr Phe Ser Lys Gly
        595                 600                 605             
Arg His Gly Phe
    610         


<210> 9436
<211> 357
<212> PRT
<213> Homo sapiens

<400> 9436
Met Gly Ile Gly Gln Leu Pro His Tyr Ala Leu Val Val Pro Ala Asp
 1               5                  10                  15      
Gly Gly Asp Trp Glu Val Arg Pro Met Trp Ser Arg Cys Leu Phe Leu
            20                  25                  30          
His His Gln Pro Asp Leu Pro Pro Ser Ser His Asp Gln Ser Ile Pro
        35                  40                  45              
Leu Leu Trp Ser Gln Glu Glu Ser Pro Pro Leu Ala Glu Asn Asp Gly
    50                  55                  60                  
Thr Asp Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala His His
65                  70                  75                  80  
Asp Trp Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu
                85                  90                  95      
Phe His Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser
            100                 105                 110         
Arg His Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu
        115                 120                 125             
Val Leu Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys
    130                 135                 140                 
Leu Arg Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp
145                 150                 155                 160 
Pro Pro Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile
                165                 170                 175     
Glu Val Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln
            180                 185                 190         
Gln Leu Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile
        195                 200                 205             
Ile Ala Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp
    210                 215                 220                 
Asp Tyr Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val
225                 230                 235                 240 
Pro Val Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn
                245                 250                 255     
Lys Ser Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala
            260                 265                 270         
Ser Tyr Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr
        275                 280                 285             
Val Glu Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr
    290                 295                 300                 
Ala Leu Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn
305                 310                 315                 320 
Tyr Ile Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn
                325                 330                 335     
Ile Arg Leu Gln Glu Lys Val Ser Lys Ser Lys Val Gly Ile Glu Pro
            340                 345                 350         
Ala Gly Trp Pro Ser
        355         


<210> 9437
<211> 428
<212> PRT
<213> Homo sapiens

<400> 9437
Met Glu Glu Ala Pro Thr His Phe Asn Ser Phe Leu Lys Lys Glu Gly
 1               5                  10                  15      
Leu Thr Phe Asn Arg Lys Arg Lys Trp Glu Leu Asp Ser Tyr Pro Ile
            20                  25                  30          
Met Leu Trp Trp Ser Pro Leu Thr Gly Glu Thr Gly Arg Leu Gly Gln
        35                  40                  45              
Cys Gly Ala Asp Ala Cys Phe Phe Thr Ile Asn Arg Thr Tyr Leu His
    50                  55                  60                  
His His Met Thr Lys Ala Phe Leu Phe Tyr Gly Thr Asp Phe Asn Ile
65                  70                  75                  80  
Asp Ser Leu Pro Leu Pro Arg Lys Ala His His Asp Trp Ala Val Phe
                85                  90                  95      
His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu Phe His Lys Pro Val
            100                 105                 110         
Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser Arg His Ser His Leu
        115                 120                 125             
Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu Val Leu Lys Ser Leu
    130                 135                 140                 
Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys Leu Arg Lys Arg Leu
145                 150                 155                 160 
Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp Pro Pro Ser Asp Arg
                165                 170                 175     
Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile Glu Val Asp Ser Tyr
            180                 185                 190         
Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln Gln Leu Lys Asn Pro
        195                 200                 205             
Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile Ile Ala Gln Tyr Lys
    210                 215                 220                 
Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp Asp Tyr Ile Thr Glu
225                 230                 235                 240 
Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val Pro Val Tyr Tyr Gly
                245                 250                 255     
Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn Lys Ser Ala Ile Leu
            260                 265                 270         
Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala Ser Tyr Ile Arg Arg
        275                 280                 285             
Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr Val Glu Trp Lys Leu
    290                 295                 300                 
Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr Ala Val Arg Glu Arg
305                 310                 315                 320 
Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn Tyr Ile Asp Ala Phe
                325                 330                 335     
Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn Ile Arg Leu Gln Glu
            340                 345                 350         
Lys Gly Leu Pro Pro Lys Arg Trp Glu Ala Glu Asp Thr His Leu Ser
        355                 360                 365             
Cys Pro Glu Pro Thr Val Phe Ala Phe Ser Pro Leu Arg Thr Pro Pro
    370                 375                 380                 
Leu Ser Ser Leu Arg Glu Met Trp Ile Ser Ser Phe Glu Gln Ser Lys
385                 390                 395                 400 
Lys Glu Ala Gln Ala Leu Arg Trp Leu Val Asp Arg Asn Gln Asn Phe
                405                 410                 415     
Ser Ser Gln Glu Phe Trp Gly Leu Val Phe Lys Asp
            420                 425             


<210> 9438
<211> 419
<212> PRT
<213> Homo sapiens

<400> 9438
Met Val Arg Ile Gln Arg Arg Lys Leu Leu Ala Ser Cys Leu Cys Val
 1               5                  10                  15      
Thr Ala Thr Val Phe Leu Leu Val Thr Leu Gln Val Met Val Glu Leu
            20                  25                  30          
Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser Leu Gln Asp Gly
        35                  40                  45              
His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn Ser Phe Leu Lys
    50                  55                  60                  
Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp Glu Leu Asp Ser
65                  70                  75                  80  
Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly Glu Thr Gly Arg
                85                  90                  95      
Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr Ile Asn Arg Thr
            100                 105                 110         
Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe Tyr Gly Thr Asp
        115                 120                 125             
Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala His His Asp Trp
    130                 135                 140                 
Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu Phe His
145                 150                 155                 160 
Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser Arg His
                165                 170                 175     
Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu Val Leu
            180                 185                 190         
Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys Leu Arg
        195                 200                 205             
Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp Pro Pro
    210                 215                 220                 
Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile Glu Val
225                 230                 235                 240 
Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln Gln Leu
                245                 250                 255     
Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile Ile Ala
            260                 265                 270         
Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp Asp Tyr
        275                 280                 285             
Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val Pro Val
    290                 295                 300                 
Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn Lys Ser
305                 310                 315                 320 
Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala Ser Tyr
                325                 330                 335     
Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr Val Glu
            340                 345                 350         
Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr Ala Leu
        355                 360                 365             
Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn Tyr Ile
    370                 375                 380                 
Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn Ile Arg
385                 390                 395                 400 
Leu Gln Glu Lys Val Ser Lys Ser Lys Val Gly Ile Glu Pro Ala Gly
                405                 410                 415     
Trp Pro Ser
            


<210> 9439
<211> 617
<212> PRT
<213> Homo sapiens

<400> 9439
Met Arg Cys Leu Ala Ala Arg Val Asn Tyr Lys Thr Leu Ile Ile Ile
 1               5                  10                  15      
Cys Ala Leu Phe Thr Leu Val Thr Val Leu Leu Trp Asn Lys Cys Ser
            20                  25                  30          
Ser Asp Lys Ala Ile Gln Phe Pro Arg Arg Ser Ser Ser Gly Phe Arg
        35                  40                  45              
Val Asp Gly Phe Glu Lys Arg Ala Ala Ala Ser Glu Ser Asn Asn Tyr
    50                  55                  60                  
Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu
65                  70                  75                  80  
Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly
                85                  90                  95      
Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn
            100                 105                 110         
Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu
        115                 120                 125             
Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val
    130                 135                 140                 
Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys
145                 150                 155                 160 
Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser
                165                 170                 175     
Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser
            180                 185                 190         
Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr
        195                 200                 205             
Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys
    210                 215                 220                 
Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu
225                 230                 235                 240 
Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys
                245                 250                 255     
Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln
            260                 265                 270         
Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn
        275                 280                 285             
Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly
    290                 295                 300                 
Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr
305                 310                 315                 320 
Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp
                325                 330                 335     
Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg
            340                 345                 350         
Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys
        355                 360                 365             
Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile
    370                 375                 380                 
Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala
385                 390                 395                 400 
His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln
                405                 410                 415     
Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu
            420                 425                 430         
Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly
        435                 440                 445             
Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His
    450                 455                 460                 
Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu
465                 470                 475                 480 
Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp
                485                 490                 495     
Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe
            500                 505                 510         
Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu
        515                 520                 525             
Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser
    530                 535                 540                 
Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr
545                 550                 555                 560 
Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp
                565                 570                 575     
Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile
            580                 585                 590         
Asp Glu Ser Pro Val Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr
        595                 600                 605             
Leu Lys Gly Ser Arg Ala Lys His Asn
    610                 615         


<210> 9440
<211> 729
<212> PRT
<213> Homo sapiens

<400> 9440
Met Gly Gly Phe Leu Pro Lys Ala Glu Gly Pro Gly Ser Gln Leu Gln
 1               5                  10                  15      
Lys Leu Leu Pro Ser Phe Leu Val Arg Glu Gln Asp Trp Asp Gln His
            20                  25                  30          
Leu Asp Lys Leu His Met Leu Gln Gln Lys Arg Ile Leu Glu Ser Pro
        35                  40                  45              
Leu Leu Arg Ala Ser Lys Glu Asn Asp Leu Ser Val Leu Arg Gln Leu
    50                  55                  60                  
Leu Leu Asp Cys Thr Cys Asp Val Arg Gln Arg Gly Ala Leu Gly Glu
65                  70                  75                  80  
Thr Ala Leu His Ile Ala Ala Leu Tyr Asp Asn Leu Glu Ala Ala Leu
                85                  90                  95      
Val Leu Met Glu Ala Ala Pro Glu Leu Val Phe Glu Pro Thr Thr Cys
            100                 105                 110         
Glu Ala Phe Ala Gly Gln Thr Ala Leu His Ile Ala Val Val Asn Gln
        115                 120                 125             
Asn Val Asn Leu Val Arg Ala Leu Leu Thr Arg Arg Ala Ser Val Ser
    130                 135                 140                 
Ala Arg Ala Thr Gly Thr Ala Phe Arg Arg Ser Pro Arg Asn Leu Ile
145                 150                 155                 160 
Tyr Phe Gly Glu His Pro Leu Ser Phe Ala Ala Cys Val Asn Ser Glu
                165                 170                 175     
Glu Ile Val Arg Leu Leu Ile Glu His Gly Ala Asp Ile Arg Ala Gln
            180                 185                 190         
Asp Ser Leu Gly Asn Thr Val Leu His Ile Leu Ile Leu Gln Pro Asn
        195                 200                 205             
Lys Thr Phe Ala Cys Gln Met Tyr Asn Leu Leu Leu Ser Tyr Asp Gly
    210                 215                 220                 
His Gly Asp His Leu Gln Pro Leu Asp Leu Val Pro Asn His Gln Gly
225                 230                 235                 240 
Leu Thr Pro Phe Lys Leu Ala Gly Val Glu Gly Asn Thr Val Met Phe
                245                 250                 255     
Gln His Leu Met Gln Lys Arg Arg His Ile Gln Trp Thr Tyr Gly Pro
            260                 265                 270         
Leu Thr Ser Ile Leu Tyr Asp Leu Thr Glu Ile Asp Ser Trp Gly Glu
        275                 280                 285             
Glu Leu Ser Phe Leu Glu Leu Val Val Ser Ser Asp Lys Arg Glu Ala
    290                 295                 300                 
Arg Gln Ile Leu Glu Gln Thr Pro Val Lys Glu Leu Val Ser Phe Lys
305                 310                 315                 320 
Trp Asn Lys Tyr Gly Arg Pro Tyr Phe Cys Ile Leu Ala Ala Leu Tyr
                325                 330                 335     
Leu Leu Tyr Met Ile Cys Phe Thr Thr Cys Cys Val Tyr Arg Pro Leu
            340                 345                 350         
Lys Phe Arg Gly Gly Asn Arg Thr His Ser Arg Asp Ile Thr Ile Leu
        355                 360                 365             
Gln Gln Lys Leu Leu Gln Glu Ala Tyr Glu Thr Arg Glu Asp Ile Ile
    370                 375                 380                 
Arg Leu Val Gly Glu Leu Val Ser Ile Val Gly Ala Val Ile Ile Leu
385                 390                 395                 400 
Leu Leu Glu Ile Pro Asp Ile Phe Arg Val Gly Ala Ser Arg Tyr Phe
                405                 410                 415     
Gly Lys Thr Ile Leu Gly Gly Pro Phe His Val Ile Ile Ile Thr Tyr
            420                 425                 430         
Ala Ser Leu Val Leu Val Thr Met Val Met Arg Leu Thr Asn Thr Asn
        435                 440                 445             
Gly Glu Val Val Pro Met Ser Phe Ala Leu Val Leu Gly Trp Cys Ser
    450                 455                 460                 
Val Met Tyr Phe Thr Arg Gly Phe Gln Met Leu Gly Pro Phe Thr Ile
465                 470                 475                 480 
Met Ile Gln Lys Met Ile Phe Gly Asp Leu Met Arg Phe Cys Trp Leu
                485                 490                 495     
Met Ala Val Val Ile Leu Gly Phe Ala Ser Ala Phe Tyr Ile Ile Phe
            500                 505                 510         
Gln Thr Glu Asp Pro Thr Ser Leu Gly Gln Phe Tyr Asp Tyr Pro Met
        515                 520                 525             
Ala Leu Phe Thr Thr Phe Glu Leu Phe Leu Thr Val Ile Asp Ala Pro
    530                 535                 540                 
Ala Asn Tyr Asp Val Asp Leu Pro Phe Met Phe Ser Ile Val Asn Phe
545                 550                 555                 560 
Ala Phe Ala Ile Ile Ala Thr Leu Leu Met Leu Asn Leu Phe Ile Ala
                565                 570                 575     
Met Met Gly Asp Thr His Trp Arg Val Ala Gln Glu Arg Asp Glu Leu
            580                 585                 590         
Trp Arg Ala Gln Val Val Ala Thr Thr Val Met Leu Glu Arg Lys Leu
        595                 600                 605             
Pro Arg Cys Leu Trp Pro Arg Ser Gly Ile Cys Gly Cys Glu Phe Gly
    610                 615                 620                 
Leu Gly Asp Arg Trp Phe Leu Arg Val Glu Asn His Asn Asp Gln Asn
625                 630                 635                 640 
Pro Leu Arg Val Leu Arg Tyr Val Glu Val Phe Lys Asn Ser Asp Lys
                645                 650                 655     
Glu Asp Asp Gln Glu His Pro Ser Glu Lys Gln Pro Ser Gly Ala Glu
            660                 665                 670         
Ser Gly Thr Leu Ala Arg Ala Ser Leu Ala Leu Pro Thr Ser Ser Leu
        675                 680                 685             
Ser Arg Thr Ala Ser Gln Ser Ser Ser His Arg Gly Trp Glu Ile Leu
    690                 695                 700                 
Arg Gln Asn Thr Leu Gly His Leu Asn Leu Gly Leu Asn Leu Ser Glu
705                 710                 715                 720 
Gly Asp Gly Glu Glu Val Tyr His Phe
                725                 


<210> 9441
<211> 729
<212> PRT
<213> Homo sapiens

<400> 9441
Met Gly Gly Phe Leu Pro Lys Ala Glu Gly Pro Gly Ser Gln Leu Gln
 1               5                  10                  15      
Lys Leu Leu Pro Ser Phe Leu Val Arg Glu Gln Asp Trp Asp Gln His
            20                  25                  30          
Leu Asp Lys Leu His Met Leu Gln Gln Lys Arg Ile Leu Glu Ser Pro
        35                  40                  45              
Leu Leu Arg Ala Ser Lys Glu Asn Asp Leu Ser Val Leu Arg Gln Leu
    50                  55                  60                  
Leu Leu Asp Cys Thr Cys Asp Val Arg Gln Arg Gly Ala Leu Gly Glu
65                  70                  75                  80  
Thr Ala Leu His Ile Ala Ala Leu Tyr Asp Asn Leu Glu Ala Ala Leu
                85                  90                  95      
Val Leu Met Glu Ala Ala Pro Glu Leu Val Phe Glu Pro Thr Thr Cys
            100                 105                 110         
Glu Ala Phe Ala Gly Gln Thr Ala Leu His Ile Ala Val Val Asn Gln
        115                 120                 125             
Asn Val Asn Leu Val Arg Ala Leu Leu Thr Arg Arg Ala Ser Val Ser
    130                 135                 140                 
Ala Arg Ala Thr Gly Thr Ala Phe Arg His Ser Pro Arg Asn Leu Ile
145                 150                 155                 160 
Tyr Phe Gly Glu His Pro Leu Ser Phe Ala Ala Cys Val Asn Ser Glu
                165                 170                 175     
Glu Ile Val Arg Leu Leu Ile Glu His Gly Ala Asp Ile Arg Ala Gln
            180                 185                 190         
Asp Ser Leu Gly Asn Thr Val Leu His Ile Leu Ile Leu Gln Pro Asn
        195                 200                 205             
Lys Thr Phe Ala Cys Gln Met Tyr Asn Leu Leu Leu Ser Tyr Asp Gly
    210                 215                 220                 
His Gly Asp His Leu Gln Pro Leu Asp Leu Val Pro Asn His Gln Gly
225                 230                 235                 240 
Leu Thr Pro Phe Lys Leu Ala Gly Val Glu Gly Asn Thr Val Met Phe
                245                 250                 255     
Gln His Leu Met Gln Lys Arg Arg His Ile Gln Trp Thr Tyr Gly Pro
            260                 265                 270         
Leu Thr Ser Ile Leu Tyr Asp Leu Thr Glu Ile Asp Ser Trp Gly Glu
        275                 280                 285             
Glu Leu Ser Phe Leu Glu Leu Val Val Ser Ser Asp Lys Arg Glu Ala
    290                 295                 300                 
Arg Gln Ile Leu Glu Gln Thr Pro Val Lys Glu Leu Val Ser Phe Lys
305                 310                 315                 320 
Trp Asn Lys Tyr Gly Arg Pro Tyr Phe Cys Ile Leu Ala Ala Leu Tyr
                325                 330                 335     
Leu Leu Tyr Met Ile Cys Phe Thr Thr Cys Cys Val Tyr Arg Pro Leu
            340                 345                 350         
Lys Phe Arg Gly Gly Asn Arg Thr His Ser Arg Asp Ile Thr Ile Leu
        355                 360                 365             
Gln Gln Lys Leu Leu Gln Glu Ala Tyr Glu Thr Arg Glu Asp Ile Ile
    370                 375                 380                 
Arg Leu Val Gly Glu Leu Val Ser Ile Val Gly Ala Val Ile Ile Leu
385                 390                 395                 400 
Leu Leu Glu Ile Pro Asp Ile Phe Arg Val Gly Ala Ser Arg Tyr Phe
                405                 410                 415     
Gly Lys Thr Ile Leu Gly Gly Pro Phe His Val Ile Ile Ile Thr Tyr
            420                 425                 430         
Ala Ser Leu Val Leu Val Thr Met Val Met Arg Leu Thr Asn Thr Asn
        435                 440                 445             
Gly Glu Val Val Pro Met Ser Phe Ala Leu Val Leu Gly Trp Cys Ser
    450                 455                 460                 
Val Met Tyr Phe Thr Arg Gly Phe Gln Met Leu Gly Pro Phe Thr Ile
465                 470                 475                 480 
Met Ile Gln Lys Met Ile Phe Gly Asp Leu Met Arg Phe Cys Trp Leu
                485                 490                 495     
Met Ala Val Val Ile Leu Gly Phe Ala Ser Ala Phe Tyr Ile Ile Phe
            500                 505                 510         
Gln Thr Glu Asp Pro Thr Ser Leu Gly Gln Phe Tyr Asp Tyr Pro Met
        515                 520                 525             
Ala Leu Phe Thr Thr Phe Glu Leu Phe Leu Thr Val Ile Asp Ala Pro
    530                 535                 540                 
Ala Asn Tyr Asp Val Asp Leu Pro Phe Met Phe Ser Ile Val Asn Phe
545                 550                 555                 560 
Ala Phe Ala Ile Ile Ala Thr Leu Leu Met Leu Asn Leu Phe Ile Ala
                565                 570                 575     
Met Met Gly Asp Thr His Trp Arg Val Ala Gln Glu Arg Asp Glu Leu
            580                 585                 590         
Trp Arg Ala Gln Val Val Ala Thr Thr Val Met Leu Glu Arg Lys Leu
        595                 600                 605             
Pro Arg Cys Leu Trp Pro Arg Ser Gly Ile Cys Gly Cys Glu Phe Gly
    610                 615                 620                 
Leu Gly Asp Arg Trp Phe Leu Arg Val Glu Asn His Asn Asp Gln Asn
625                 630                 635                 640 
Pro Leu Arg Val Leu Arg Tyr Val Glu Val Phe Lys Asn Ser Asp Lys
                645                 650                 655     
Glu Asp Asp Gln Glu His Pro Ser Glu Lys Gln Pro Ser Gly Ala Glu
            660                 665                 670         
Ser Gly Thr Leu Ala Arg Ala Ser Leu Ala Leu Pro Thr Ser Ser Leu
        675                 680                 685             
Ser Arg Thr Ala Ser Gln Ser Ser Ser His Arg Gly Trp Glu Ile Leu
    690                 695                 700                 
Arg Gln Asn Thr Leu Gly His Leu Asn Leu Gly Leu Asn Leu Ser Glu
705                 710                 715                 720 
Gly Asp Gly Glu Glu Val Tyr His Phe
                725                 


<210> 9442
<211> 1503
<212> PRT
<213> Homo sapiens

<400> 9442
Met Pro Gly Pro Pro Ala Leu Arg Arg Arg Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Val Leu Leu Ile Ala Gly Ser Ala Gly Ala Ala Pro Leu Pro Gln Thr
            20                  25                  30          
Gly Ala Gly Glu Ala Pro Pro Ala Ala Glu Val Ser Ser Ser Phe Val
        35                  40                  45              
Ile Leu Cys Val Cys Ser Leu Ile Ile Leu Ile Val Leu Ile Ala Asn
    50                  55                  60                  
Cys Val Ser Cys Cys Lys Asp Pro Glu Ile Asp Phe Lys Glu Phe Glu
65                  70                  75                  80  
Asp Asn Phe Asp Asp Glu Ile Asp Phe Thr Pro Pro Ala Glu Asp Thr
                85                  90                  95      
Pro Ser Val Gln Ser Pro Ala Glu Val Phe Thr Leu Ser Val Pro Asn
            100                 105                 110         
Ile Ser Leu Pro Ala Pro Ser Gln Phe Gln Pro Ser Val Glu Gly Leu
        115                 120                 125             
Lys Ser Gln Val Ala Arg His Ser Leu Asn Tyr Ile Gln Glu Ile Gly
    130                 135                 140                 
Asn Gly Trp Phe Gly Lys Val Leu Leu Gly Glu Ile Tyr Thr Gly Thr
145                 150                 155                 160 
Ser Val Ala Arg Val Ile Val Lys Glu Leu Lys Ala Ser Ala Asn Pro
                165                 170                 175     
Lys Glu Gln Asp Thr Phe Leu Lys Asn Gly Glu Pro Tyr Tyr Ile Leu
            180                 185                 190         
Gln His Pro Asn Ile Leu Gln Cys Val Gly Gln Cys Val Glu Ala Ile
        195                 200                 205             
Pro Tyr Leu Leu Val Phe Glu Phe Cys Asp Leu Gly Asp Leu Lys Ala
    210                 215                 220                 
Tyr Leu Arg Ser Glu Gln Glu His Met Arg Gly Asp Ser Gln Thr Met
225                 230                 235                 240 
Leu Leu Gln Arg Met Ala Cys Glu Val Ala Ala Gly Leu Ala Ala Met
                245                 250                 255     
His Lys Leu His Phe Leu His Ser Asp Leu Ala Leu Arg Asn Cys Phe
            260                 265                 270         
Leu Thr Ser Asp Leu Asn Val Lys Val Gly Asp Tyr Gly Ile Gly Phe
        275                 280                 285             
Ser Arg Tyr Lys Glu Asp Tyr Ile Glu Thr Asp Asp Lys Lys Val Phe
    290                 295                 300                 
Pro Leu Arg Trp Thr Ala Pro Glu Leu Val Thr Ser Phe Gln Asp Arg
305                 310                 315                 320 
Leu Leu Thr Ala Asp Gln Thr Lys Tyr Ser Asn Ile Trp Ser Leu Gly
                325                 330                 335     
Val Thr Leu Trp Glu Leu Phe Asp Asn Ala Ala Gln Pro Tyr Ser Asn
            340                 345                 350         
Leu Ser Asn Leu Asp Val Leu Asn Gln Val Ile Arg Glu Arg Asp Thr
        355                 360                 365             
Lys Leu Pro Lys Pro Gln Leu Glu Gln Pro Tyr Ser Asp Arg Trp Tyr
    370                 375                 380                 
Glu Val Leu Gln Phe Cys Trp Leu Ser Pro Glu Lys Arg Pro Ala Ala
385                 390                 395                 400 
Glu Asp Val His Arg Leu Leu Thr Tyr Leu Arg Leu Gln Ser Gln Arg
                405                 410                 415     
Asp Ser Glu Val Asp Phe Glu Gln Gln Trp Asn Ala Leu Lys Pro Asn
            420                 425                 430         
Thr Asn Ser Arg Asp Ser Ser Asn Asn Ala Ala Phe Pro Ile Leu Asp
        435                 440                 445             
His Phe Ala Arg Asp Arg Leu Gly Arg Glu Met Glu Glu Val Leu Thr
    450                 455                 460                 
Val Thr Glu Thr Ser Gln Gly Leu Ser Phe Glu Tyr Val Trp Glu Ala
465                 470                 475                 480 
Ala Lys His Asp His Phe Asp Glu Arg Ser Arg Gly His Leu Asp Glu
                485                 490                 495     
Gly Leu Ser Tyr Thr Ser Ile Phe Tyr Pro Val Glu Val Phe Glu Ser
            500                 505                 510         
Ser Leu Ser Asp Pro Gly Pro Gly Lys Gln Asp Asp Ser Gly Gln Asp
        515                 520                 525             
Val Pro Leu Arg Val Pro Gly Val Val Pro Val Phe Asp Ala His Asn
    530                 535                 540                 
Leu Ser Val Gly Ser Asp Tyr Tyr Ile Gln Leu Glu Glu Lys Ser Gly
545                 550                 555                 560 
Ser Asn Leu Glu Leu Asp Tyr Pro Pro Ala Leu Leu Thr Thr Asp Met
                565                 570                 575     
Asp Asn Pro Glu Arg Thr Gly Pro Glu Leu Ser Gln Leu Thr Ala Leu
            580                 585                 590         
Arg Ser Val Glu Leu Glu Glu Ser Ser Thr Asp Glu Asp Phe Phe Gln
        595                 600                 605             
Ser Ser Thr Asp Pro Lys Asp Ser Ser Leu Pro Gly Asp Leu His Val
    610                 615                 620                 
Thr Ser Gly Pro Glu Ser Pro Phe Asn Asn Ile Phe Asn Asp Val Asp
625                 630                 635                 640 
Lys Ser Glu Asp Leu Pro Ser His Gln Lys Ile Phe Asp Leu Met Glu
                645                 650                 655     
Leu Asn Gly Val Gln Ala Asp Phe Lys Pro Ala Thr Leu Ser Ser Ser
            660                 665                 670         
Leu Asp Asn Pro Lys Glu Ser Val Ile Thr Gly His Phe Glu Lys Glu
        675                 680                 685             
Lys Pro Arg Lys Ile Phe Asp Ser Glu Pro Leu Cys Leu Ser Asp Asn
    690                 695                 700                 
Leu Met His Gln Asp Asn Phe Asp Pro Leu Asn Val Gln Glu Leu Ser
705                 710                 715                 720 
Glu Asn Phe Leu Phe Leu Gln Glu Lys Asn Leu Leu Lys Gly Ser Leu
                725                 730                 735     
Ser Ser Lys Glu His Ile Asn Asp Leu Gln Thr Glu Leu Lys Asn Ala
            740                 745                 750         
Gly Phe Thr Glu Ala Met Leu Glu Thr Ser Cys Arg Asn Ser Leu Asp
        755                 760                 765             
Thr Glu Leu Gln Phe Ala Glu Asn Lys Pro Gly Leu Ser Leu Leu Gln
    770                 775                 780                 
Glu Asn Val Ser Thr Lys Gly Asp Asp Thr Asp Val Met Leu Thr Gly
785                 790                 795                 800 
Asp Thr Leu Ser Thr Ser Leu Gln Ser Ser Pro Glu Val Gln Val Pro
                805                 810                 815     
Pro Thr Ser Phe Glu Thr Glu Glu Thr Pro Arg Arg Val Pro Pro Asp
            820                 825                 830         
Ser Leu Pro Thr Gln Gly Glu Thr Gln Pro Thr Cys Leu Asp Val Ile
        835                 840                 845             
Val Pro Glu Asp Cys Leu His Gln Asp Ile Ser Pro Asp Ala Val Thr
    850                 855                 860                 
Val Pro Val Glu Ile Leu Ser Thr Asp Ala Arg Thr His Ser Leu Asp
865                 870                 875                 880 
Asn Arg Ser Gln Asp Ser Pro Gly Glu Ser Glu Glu Thr Leu Arg Leu
                885                 890                 895     
Thr Glu Ser Asp Ser Val Leu Ala Asp Asp Ile Leu Ala Ile Arg Val
            900                 905                 910         
Ser Val Gly Ser Ser Leu Pro Glu Leu Gly Gln Glu Leu His Asn Lys
        915                 920                 925             
Pro Phe Ser Glu Asp His His Ser His Arg Arg Leu Glu Lys Asn Leu
    930                 935                 940                 
Glu Ala Val Glu Thr Leu Asn Gln Leu Asn Ser Lys Asp Ala Ala Lys
945                 950                 955                 960 
Glu Ala Gly Leu Val Ser Ala Leu Ser Ser Asp Ser Thr Ser Gln Asp
                965                 970                 975     
Ser Leu Leu Glu Asp Ser Leu Ser Ala Pro Phe Pro Ala Ser Glu Pro
            980                 985                 990         
Ser Leu Glu Thr Pro Asp Ser Leu Glu Ser Val Asp Val His Glu Ala
        995                 1000                1005            
Leu Leu Asp Ser Leu Gly Ser His Thr Pro Gln Lys Leu Val Pro Pro
    1010                1015                1020                
Asp Lys Pro Ala Asp Ser Gly Tyr Glu Thr Glu Asn Leu Glu Ser Pro
1025                1030                1035                1040
Glu Trp Thr Leu His Pro Ala Pro Glu Gly Thr Ala Asp Ser Glu Pro
                1045                1050                1055    
Ala Thr Thr Gly Asp Gly Gly His Ser Gly Leu Pro Pro Asn Pro Val
            1060                1065                1070        
Ile Val Ile Ser Asp Ala Gly Asp Gly His Arg Gly Thr Glu Val Thr
        1075                1080                1085            
Pro Glu Thr Phe Thr Ala Gly Ser Gln Gly Ser Tyr Arg Asp Ser Ala
    1090                1095                1100                
Tyr Phe Ser Asp Asn Asp Ser Glu Pro Glu Lys Arg Ser Glu Glu Val
1105                1110                1115                1120
Pro Gly Thr Ser Pro Ser Ala Leu Val Leu Val Gln Glu Gln Pro Leu
                1125                1130                1135    
Pro Glu Pro Val Leu Pro Glu Gln Ser Pro Ala Ala Gln Asp Ser Cys
            1140                1145                1150        
Leu Glu Ala Arg Lys Ser Gln Pro Asp Glu Ser Cys Leu Ser Ala Leu
        1155                1160                1165            
His Asn Ser Ser Asp Leu Glu Leu Arg Ala Thr Pro Glu Pro Ala Gln
    1170                1175                1180                
Thr Gly Val Pro Gln Gln Val His Pro Thr Glu Asp Glu Ala Ser Ser
1185                1190                1195                1200
Pro Trp Ser Val Leu Asn Ala Glu Leu Ser Ser Gly Asp Asp Phe Glu
                1205                1210                1215    
Thr Gln Asp Asp Arg Pro Cys Thr Leu Ala Ser Thr Gly Thr Asn Thr
            1220                1225                1230        
Asn Glu Leu Leu Ala Tyr Thr Asn Ser Ala Leu Asp Lys Ser Leu Ser
        1235                1240                1245            
Ser His Ser Glu Gly Pro Lys Leu Lys Glu Pro Asp Ile Glu Gly Lys
    1250                1255                1260                
Tyr Leu Gly Lys Leu Gly Val Ser Gly Met Leu Asp Leu Ser Glu Asp
1265                1270                1275                1280
Gly Met Asp Ala Asp Glu Glu Asp Glu Asn Ser Asp Asp Ser Asp Glu
                1285                1290                1295    
Asp Leu Arg Ala Phe Asn Leu His Ser Leu Ser Ser Glu Ser Glu Asp
            1300                1305                1310        
Glu Thr Glu His Pro Val Pro Ile Ile Leu Ser Asn Glu Asp Gly Arg
        1315                1320                1325            
His Leu Arg Ser Leu Leu Lys Pro Thr Ala Ala Asn Ala Pro Asp Pro
    1330                1335                1340                
Leu Pro Glu Asp Trp Lys Lys Glu Lys Lys Ala Val Thr Phe Phe Asp
1345                1350                1355                1360
Asp Val Thr Val Tyr Leu Phe Asp Gln Glu Thr Pro Thr Lys Glu Leu
                1365                1370                1375    
Gly Pro Cys Gly Gly Glu Ala Cys Gly Pro Asp Leu Ser Gly Pro Ala
            1380                1385                1390        
Pro Ala Ser Gly Ser Pro Tyr Leu Ser Arg Cys Ile Asn Ser Glu Ser
        1395                1400                1405            
Ser Thr Asp Glu Glu Gly Gly Gly Phe Glu Trp Asp Asp Asp Phe Ser
    1410                1415                1420                
Pro Asp Pro Phe Met Ser Lys Thr Thr Ser Asn Leu Leu Ser Ser Lys
1425                1430                1435                1440
Pro Ser Leu Gln Thr Ser Lys Tyr Phe Ser Pro Pro Pro Pro Ala Arg
                1445                1450                1455    
Ser Thr Glu Gln Ser Trp Pro His Ser Ala Pro Tyr Ser Arg Phe Ser
            1460                1465                1470        
Ile Ser Pro Ala Asn Ile Ala Ser Phe Ser Leu Thr His Leu Thr Asp
        1475                1480                1485            
Ser Asp Ile Glu Gln Gly Gly Ser Ser Glu Asp Gly Glu Lys Asp
    1490                1495                1500            


<210> 9443
<211> 519
<212> PRT
<213> Homo sapiens

<400> 9443
Met Glu Glu His Ser Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly
 1               5                  10                  15      
Ser Leu Glu Glu Asp Ser Val Val His Ser Val Glu Asn Asp Ser Gln
            20                  25                  30          
Asn Met Met Glu Ser Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg
        35                  40                  45              
Phe Lys Ala Asn Gly Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln
    50                  55                  60                  
Pro Val Pro Ala Lys Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg
65                  70                  75                  80  
Ser Ser Pro Ser Leu Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser Tyr
                85                  90                  95      
Asp Gly Thr Asp Lys Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu
            100                 105                 110         
Asn Ile Thr Ser Ser Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe
        115                 120                 125             
Asp His Tyr Thr Gly Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu
    130                 135                 140                 
Lys Pro Pro Tyr Ser Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn
145                 150                 155                 160 
Val Tyr Ser Leu Gly Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu
                165                 170                 175     
Leu Ala Met Trp Asn Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro
            180                 185                 190         
Ile Ser Arg Ser Gly Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala
        195                 200                 205             
Arg Lys Met Ser Ile Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr
    210                 215                 220                 
Arg His Lys Glu Leu Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys
225                 230                 235                 240 
Tyr Ser Ser Ser Ser Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu
                245                 250                 255     
Pro Arg Leu Tyr Arg Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu
            260                 265                 270         
Pro Pro Arg Asn Ser Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu
        275                 280                 285             
Lys Asp Leu Pro His Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe
    290                 295                 300                 
Ser Ser Leu Ser Ser Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu
305                 310                 315                 320 
Gly Asn Pro Tyr Val Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg
                325                 330                 335     
Val Ala Arg Lys Met Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp
            340                 345                 350         
Asp Phe Asp Gln Ala Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu
        355                 360                 365             
Leu Ala Gly Glu Ser Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser
    370                 375                 380                 
Cys Gly Ser Val Glu Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln
385                 390                 395                 400 
Ala Ser Gly Thr Pro Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile
                405                 410                 415     
Ser Ser Ile Ser Gly Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln
            420                 425                 430         
Arg Glu Glu Arg Leu Arg Glu Gln Glu Met Glu Arg Leu Val Ile Phe
        435                 440                 445             
Ile Ser Thr Val Ile Asp Leu Thr Val Ser Leu Thr Ser Ile Tyr Arg
    450                 455                 460                 
Ala Ala Leu Glu Met Asp Ser Arg Ile Cys Gly Asn Ile Gly Tyr Ser
465                 470                 475                 480 
Cys Ser Leu Ala Thr Ala Ala Ile Phe Leu Phe Ser Pro Ala Ile Leu
                485                 490                 495     
Leu Leu Pro Ile Ser Leu Leu Ile Gly Leu Phe Gly Tyr Leu Glu Gly
            500                 505                 510         
Leu Gln Glu Leu Met Leu Ile
        515                 


<210> 9444
<211> 787
<212> PRT
<213> Homo sapiens

<400> 9444
Met Glu Glu His Ser Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly
 1               5                  10                  15      
Ser Leu Glu Glu Asp Ser Val Val His Ser Val Glu Asn Asp Ser Gln
            20                  25                  30          
Asn Met Met Glu Ser Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg
        35                  40                  45              
Phe Lys Ala Asn Gly Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln
    50                  55                  60                  
Pro Val Pro Ala Lys Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg
65                  70                  75                  80  
Ser Ser Pro Ser Leu Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser His
                85                  90                  95      
Asp Gly Thr Asp Lys Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu
            100                 105                 110         
Asn Thr Thr Ser Ser Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe
        115                 120                 125             
Asp His Tyr Thr Gly Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu
    130                 135                 140                 
Lys Pro Pro Tyr Ser Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn
145                 150                 155                 160 
Val Tyr Ser Leu Gly Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu
                165                 170                 175     
Leu Ala Met Trp Asn Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro
            180                 185                 190         
Ile Ser Arg Ser Gly Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala
        195                 200                 205             
Arg Lys Met Ser Ile Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr
    210                 215                 220                 
Arg His Lys Glu Leu Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys
225                 230                 235                 240 
Tyr Ser Ser Ser Ser Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu
                245                 250                 255     
Pro Arg Leu Tyr Arg Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu
            260                 265                 270         
Pro Pro Arg Asn Ser Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu
        275                 280                 285             
Lys Asp Leu Pro His Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe
    290                 295                 300                 
Ser Ser Leu Ser Ser Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu
305                 310                 315                 320 
Gly Asn Pro Tyr Val Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg
                325                 330                 335     
Val Ala Arg Lys Met Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp
            340                 345                 350         
Asp Phe Asp Gln Ala Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu
        355                 360                 365             
Leu Ala Gly Glu Ser Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser
    370                 375                 380                 
Cys Gly Ser Val Glu Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln
385                 390                 395                 400 
Ala Ser Gly Thr Pro Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile
                405                 410                 415     
Ser Ser Ile Ser Gly Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln
            420                 425                 430         
Arg Glu Glu Arg Leu Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln
        435                 440                 445             
Arg Leu Glu Thr Ile Leu Ser Leu Cys Ala Glu Tyr Thr Lys Pro Asp
    450                 455                 460                 
Ser Arg Leu Ser Thr Gly Thr Thr Val Glu Asp Val Gln Lys Ile Asn
465                 470                 475                 480 
Lys Glu Leu Glu Lys Leu Gln Leu Ser Asp Glu Glu Ser Val Phe Glu
                485                 490                 495     
Glu Ala Leu Met Ser Pro Asp Thr Arg Tyr Arg Cys His Arg Lys Asp
            500                 505                 510         
Ser Leu Pro Asp Ala Asp Leu Ala Ser Cys Gly Ser Leu Ser Gln Ser
        515                 520                 525             
Ser Ala Ser Phe Phe Thr Pro Arg Ser Thr Arg Asn Asp Glu Leu Leu
    530                 535                 540                 
Ser Asp Leu Thr Arg Thr Pro Pro Pro Pro Ser Ser Thr Phe Pro Lys
545                 550                 555                 560 
Ala Ser Ser Glu Ser Ser Tyr Leu Ser Ile Leu Pro Lys Thr Pro Glu
                565                 570                 575     
Gly Ile Ser Glu Glu Gln Arg Ser Gln Glu Leu Ala Ala Met Glu Glu
            580                 585                 590         
Thr Arg Ile Val Ile Leu Asn Asn Leu Glu Glu Leu Lys Gln Lys Ile
        595                 600                 605             
Lys Asp Ile Asn Asp Gln Met Asp Glu Ser Phe Arg Glu Leu Asp Met
    610                 615                 620                 
Glu Cys Ala Leu Leu Asp Gly Glu Gln Lys Ser Glu Thr Thr Glu Leu
625                 630                 635                 640 
Met Lys Glu Lys Glu Ile Leu Asp His Leu Asn Arg Lys Ile Ala Glu
                645                 650                 655     
Leu Glu Lys Asn Ile Val Gly Glu Lys Thr Lys Glu Lys Val Lys Leu
            660                 665                 670         
Asp Ala Glu Arg Glu Lys Leu Glu Arg Leu Gln Glu Leu Tyr Ser Glu
        675                 680                 685             
Gln Lys Thr Gln Leu Asp Asn Cys Pro Glu Ser Met Arg Glu Gln Leu
    690                 695                 700                 
Gln Gln Gln Leu Lys Arg Asp Ala Asp Leu Leu Asp Val Glu Ser Lys
705                 710                 715                 720 
His Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu His Glu Ser Arg Leu
                725                 730                 735     
Asp Glu Glu Lys Glu Asn Leu Thr Gln Gln Leu Leu Arg Glu Val Ala
            740                 745                 750         
Glu Tyr Gln Arg Asn Ile Val Ser Arg Lys Glu Lys Ile Ser Ala Leu
        755                 760                 765             
Lys Lys Gln Ala Asn His Ile Val Gln Gln Ala Gln Arg Glu Gln Asp
    770                 775                 780                 
His Phe Val
785         


<210> 9445
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 9445
Met Glu Glu His Ser Tyr Ile Gln Lys Glu Leu Asp Leu Gln Asn Gly
 1               5                  10                  15      
Ser Leu Glu Glu Asp Ser Val Val His Ser Val Glu Asn Asp Ser Gln
            20                  25                  30          
Asn Met Met Glu Ser Leu Ser Pro Lys Lys Tyr Ser Ser Ser Leu Arg
        35                  40                  45              
Phe Lys Ala Asn Gly Asp Tyr Ser Gly Ser Tyr Leu Thr Leu Ser Gln
    50                  55                  60                  
Pro Val Pro Ala Lys Arg Ser Pro Ser Pro Leu Gly Thr Ser Val Arg
65                  70                  75                  80  
Ser Ser Pro Ser Leu Ala Lys Ile Gln Gly Ser Lys Gln Phe Ser Tyr
                85                  90                  95      
Asp Gly Thr Asp Lys Asn Ile Pro Met Lys Pro Pro Thr Pro Leu Leu
            100                 105                 110         
Asn Thr Thr Ser Ser Leu Ser Gly Tyr Pro Leu Gly Arg Ala Asp Phe
        115                 120                 125             
Asp His Tyr Thr Gly Arg Asp Ser Glu Arg Ala Leu Arg Leu Ser Glu
    130                 135                 140                 
Lys Pro Pro Tyr Ser Lys Tyr Ser Ser Arg His Lys Ser His Asp Asn
145                 150                 155                 160 
Val Tyr Ser Leu Gly Gly Leu Glu Gly Arg Lys Ala Ser Gly Ser Leu
                165                 170                 175     
Leu Ala Met Trp Asn Gly Ser Ser Leu Ser Asp Ala Gly Pro Pro Pro
            180                 185                 190         
Ile Ser Arg Ser Gly Ala Ala Ser Met Pro Ser Ser Pro Lys Gln Ala
        195                 200                 205             
Arg Lys Met Ser Ile Gln Asp Ser Leu Ala Leu Gln Pro Lys Leu Thr
    210                 215                 220                 
Arg His Lys Glu Leu Ala Ser Glu Asn Ile Asn Leu Arg Thr Arg Lys
225                 230                 235                 240 
Tyr Ser Ser Ser Ser Leu Ser His Met Gly Ala Tyr Ser Arg Ser Leu
                245                 250                 255     
Pro Arg Leu Tyr Arg Ala Thr Glu Asn Gln Leu Thr Pro Leu Ser Leu
            260                 265                 270         
Pro Pro Arg Asn Ser Leu Gly Asn Ser Lys Arg Thr Lys Leu Gly Glu
        275                 280                 285             
Lys Asp Leu Pro His Ser Val Ile Asp Asn Asp Asn Tyr Leu Asn Phe
    290                 295                 300                 
Ser Ser Leu Ser Ser Gly Ala Leu Pro Tyr Lys Thr Ser Ala Ser Glu
305                 310                 315                 320 
Gly Asn Pro Tyr Val Ser Ser Thr Leu Ser Val Pro Ala Ser Pro Arg
                325                 330                 335     
Val Ala Arg Lys Met Leu Leu Ala Ser Thr Ser Ser Cys Ala Ser Asp
            340                 345                 350         
Asp Phe Asp Gln Ala Ser Tyr Val Gly Thr Asn Pro Ser His Ser Leu
        355                 360                 365             
Leu Ala Gly Glu Ser Asp Arg Val Phe Ala Thr Arg Arg Asn Phe Ser
    370                 375                 380                 
Cys Gly Ser Val Glu Phe Asp Glu Ala Asp Leu Glu Ser Leu Arg Gln
385                 390                 395                 400 
Ala Ser Gly Thr Pro Gln Pro Ala Leu Arg Glu Arg Lys Ser Ser Ile
                405                 410                 415     
Ser Ser Ile Ser Gly Arg Asp Asp Leu Met Asp Tyr His Arg Arg Gln
            420                 425                 430         
Arg Glu Glu Arg Leu Arg Glu Gln Glu Met Glu Arg Leu Glu Arg Gln
        435                 440                 445             
Arg Leu Glu Thr Ile Leu Ser Leu Cys Ala Glu Tyr Thr Lys Pro Asp
    450                 455                 460                 
Ser Arg Leu Ser Thr Gly Thr Thr Val Glu Asp Val Gln Lys Ile Asn
465                 470                 475                 480 
Lys Glu Leu Glu Lys Leu Gln Leu Ser Asp Glu Glu Ser Val Phe Glu
                485                 490                 495     
Glu Ala Leu Met Ser Pro Asp Thr Arg Tyr Arg Cys His Arg Lys Asp
            500                 505                 510         
Ser Leu Pro Asp Ala Asp Leu Ala Ser Cys Gly Ser Leu Ser Gln Ser
        515                 520                 525             
Ser Ala Ser Phe Phe Thr Pro Arg Ser Thr Arg Asn Asp Glu Leu Leu
    530                 535                 540                 
Ser Asp Leu Thr Arg Thr Pro Pro Pro Pro Ser Ser Thr Phe Pro Lys
545                 550                 555                 560 
Ala Ser Ser Glu Ser Ser Tyr Leu Ser Ile Leu Pro Lys Thr Pro Glu
                565                 570                 575     
Gly Ile Ser Glu Glu Gln Arg Ser Gln Glu Leu Ala Ala Met Glu Glu
            580                 585                 590         
Thr Arg Ile Val Ile Leu Asn Asn Leu Glu Glu Leu Lys Gln Lys Ile
        595                 600                 605             
Lys Asp Ile Asn Asp Gln Met Asp Glu Ser Phe Arg Glu Leu Asp Met
    610                 615                 620                 
Glu Cys Ala Leu Leu Asp Gly Glu Gln Lys Ser Glu Thr Thr Glu Leu
625                 630                 635                 640 
Met Lys Glu Lys Glu Ile Leu Asp His Leu Asn Arg Lys Ile Ala Glu
                645                 650                 655     
Leu Glu Lys Asn Ile Val Gly Glu Lys Thr Lys Asp Ala Asp Leu Leu
            660                 665                 670         
Asp Val Glu Ser Lys His Phe Glu Asp Leu Glu Phe Gln Gln Leu Glu
        675                 680                 685             
His Glu Ser Arg Leu Asp Glu Glu Lys Glu Asn Leu Thr Gln Gln Leu
    690                 695                 700                 
Leu Arg Glu Val Ala Glu Tyr Gln Arg Asn Ile Val Ser Arg Lys Glu
705                 710                 715                 720 
Lys Ile Ser Ala Leu Lys Lys Gln Ala Asn His Ile Val Gln Gln Ala
                725                 730                 735     
Gln Arg Glu Gln Asp His Phe Val Lys Glu Lys Asn Asn Leu Ile Met
            740                 745                 750         
Met Leu Gln Arg Glu Lys Glu Asn Leu Cys Asn Leu Glu Lys Lys Tyr
        755                 760                 765             
Ser Ser Leu Ser Gly Gly Lys Gly Phe Pro Val Asn Pro Asn Thr Leu
    770                 775                 780                 
Lys Glu Gly Tyr Ile Ser Val Asn Glu Ile Asn Glu Pro Cys Gly Asn
785                 790                 795                 800 
Ser Thr Asn Leu Ser Pro Ser Thr Gln Phe Pro Ala Asp Ala Asp Ala
                805                 810                 815     
Val Ala Thr Glu Pro Ala Thr Ala Val Leu Ala Ser Gln Pro Gln Ser
            820                 825                 830         
Lys Glu His Phe Arg Ser Leu Glu Glu Arg Lys Lys Gln His Lys Glu
        835                 840                 845             
Gly Leu Tyr Leu Ser Asp Thr Leu Pro Arg Lys Lys Thr Thr Ser Ser
    850                 855                 860                 
Ile Ser Pro His Phe Ser Ser Ala Thr Met Gly Arg Ser Ile Thr Pro
865                 870                 875                 880 
Lys Ala His Leu Pro Leu Gly Gln Ser Asn Ser Cys Gly Ser Val Leu
                885                 890                 895     
Pro Pro Ser Leu Ala Ala Met Ala Lys Asp Ser Glu Ser Arg Arg Met
            900                 905                 910         
Leu Arg Gly Tyr Asn His Gln Gln Met Ser Glu Gly His Arg Gln Lys
        915                 920                 925             
Ser Glu Phe Tyr Asn Arg Thr Ala Ser Glu Ser Asn Val Tyr Leu Asn
    930                 935                 940                 
Ser Phe His Tyr Pro Asp His Ser Tyr Lys Asp Gln Ala Phe Asp Thr
945                 950                 955                 960 
Leu Ser Leu Asp Ser Ser Asp Ser Met Glu Thr Ser Ile Ser Ala Cys
                965                 970                 975     
Ser Pro Asp Asn Ile Ser Ser Ala Ser Thr Ser Asn Ile Ala Arg Ile
            980                 985                 990         
Glu Glu Met Glu Arg Leu Leu Lys Gln Ala His Ala Glu Lys Thr Arg
        995                 1000                1005            
Leu Leu Glu Ser Arg Glu Arg Glu Met Glu Ala Lys Lys Arg Ala Leu
    1010                1015                1020                
Glu Glu Glu Lys Arg Arg Arg Glu Ile Leu Glu Lys Arg Leu Gln Glu
1025                1030                1035                1040
Glu Thr Ser Gln Arg Gln Lys Leu Ile Glu Lys Glu Val Lys Ile Arg
                1045                1050                1055    
Glu Arg Gln Arg Ala Gln Ala Arg Pro Leu Thr Arg Tyr Leu Pro Val
            1060                1065                1070        
Arg Lys Glu Asp Phe Asp Leu Arg Ser His Val Glu Thr Ala Gly His
        1075                1080                1085            
Asn Ile Asp Thr Cys Tyr His Val Ser Ile Thr Glu Lys Thr Cys Arg
    1090                1095                1100                
Gly Phe Leu Ile Lys Met Gly Gly Lys Ile Lys Thr Trp Lys Lys Arg
1105                1110                1115                1120
Trp Phe Val Phe Asp Arg Asn Lys Arg Thr Phe Ser Tyr Tyr Ala Asp
                1125                1130                1135    
Lys His Glu Thr Lys Leu Lys Gly Val Ile Tyr Phe Gln Ala Ile Glu
            1140                1145                1150        
Glu Val Tyr Tyr Asp His Leu Lys Asn Ala Asn Lys Ser Pro Asn Pro
        1155                1160                1165            
Leu Leu Thr Phe Ser Val Lys Thr His Asp Arg Ile Tyr Tyr Met Val
    1170                1175                1180                
Ala Pro Ser Pro Glu Ala Met Arg Ile Trp Met Asp Val Ile Val Thr
1185                1190                1195                1200
Gly Ala Glu Gly Tyr Thr His Phe Leu Leu
                1205                1210


<210> 9446
<211> 907
<212> PRT
<213> Homo sapiens

<400> 9446
Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu
 1               5                  10                  15      
Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg
            20                  25                  30          
Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu
        35                  40                  45              
Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu
    50                  55                  60                  
Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln
65                  70                  75                  80  
Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg
                85                  90                  95      
Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly
            100                 105                 110         
Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His
        115                 120                 125             
Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg
    130                 135                 140                 
Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly
145                 150                 155                 160 
Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu
                165                 170                 175     
Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr
            180                 185                 190         
Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn
        195                 200                 205             
Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser
    210                 215                 220                 
Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp
225                 230                 235                 240 
Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu
                245                 250                 255     
Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile
            260                 265                 270         
Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe
        275                 280                 285             
Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu
    290                 295                 300                 
Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu
305                 310                 315                 320 
Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr
                325                 330                 335     
Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro
            340                 345                 350         
Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro
        355                 360                 365             
Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn
    370                 375                 380                 
Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu
385                 390                 395                 400 
Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn
                405                 410                 415     
Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn
            420                 425                 430         
Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu
        435                 440                 445             
Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn
    450                 455                 460                 
Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys
465                 470                 475                 480 
Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn
                485                 490                 495     
Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly
            500                 505                 510         
Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp
        515                 520                 525             
Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser
    530                 535                 540                 
Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile
545                 550                 555                 560 
Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala
                565                 570                 575     
Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile
            580                 585                 590         
Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val
        595                 600                 605             
Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe
    610                 615                 620                 
Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile
625                 630                 635                 640 
Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr
                645                 650                 655     
Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe
            660                 665                 670         
Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys
        675                 680                 685             
Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser
    690                 695                 700                 
Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro
705                 710                 715                 720 
Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys
                725                 730                 735     
Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp
            740                 745                 750         
Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile
        755                 760                 765             
Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe
    770                 775                 780                 
Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val
785                 790                 795                 800 
Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn
                805                 810                 815     
Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val
            820                 825                 830         
Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser
        835                 840                 845             
Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser
    850                 855                 860                 
Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu
865                 870                 875                 880 
Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys
                885                 890                 895     
His Leu Ser Ser Val Ala Phe Val Pro Cys Leu
            900                 905         


<210> 9447
<211> 1453
<212> PRT
<213> Homo sapiens

<400> 9447
Met Met Leu Pro Gln Asn Ser Trp His Ile Asp Phe Gly Arg Cys Cys
 1               5                  10                  15      
Cys His Gln Asn Leu Phe Ser Ala Val Val Thr Cys Ile Leu Leu Leu
            20                  25                  30          
Asn Ser Cys Phe Leu Ile Ser Ser Phe Asn Gly Thr Asp Leu Glu Leu
        35                  40                  45              
Arg Leu Val Asn Gly Asp Gly Pro Cys Ser Gly Thr Val Glu Val Lys
    50                  55                  60                  
Phe Gln Gly Gln Trp Gly Thr Val Cys Asp Asp Gly Trp Asn Thr Thr
65                  70                  75                  80  
Ala Ser Thr Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Phe Ala
                85                  90                  95      
Met Phe Arg Phe Gly Gln Ala Val Thr Arg His Gly Lys Ile Trp Leu
            100                 105                 110         
Asp Asp Val Ser Cys Tyr Gly Asn Glu Ser Ala Leu Trp Glu Cys Gln
        115                 120                 125             
His Arg Glu Trp Gly Ser His Asn Cys Tyr His Gly Glu Asp Val Gly
    130                 135                 140                 
Val Asn Cys Tyr Gly Glu Ala Asn Leu Gly Leu Arg Leu Val Asp Gly
145                 150                 155                 160 
Asn Asn Ser Cys Ser Gly Arg Val Glu Val Lys Phe Gln Glu Arg Trp
                165                 170                 175     
Gly Thr Ile Cys Asp Asp Gly Trp Asn Leu Asn Thr Ala Ala Val Val
            180                 185                 190         
Cys Arg Gln Leu Gly Cys Pro Ser Ser Phe Ile Ser Ser Gly Val Val
        195                 200                 205             
Asn Ser Pro Ala Val Leu Arg Pro Ile Trp Leu Asp Asp Ile Leu Cys
    210                 215                 220                 
Gln Gly Asn Glu Leu Ala Leu Trp Asn Cys Arg His Arg Gly Trp Gly
225                 230                 235                 240 
Asn His Asp Cys Ser His Asn Glu Asp Val Thr Leu Thr Cys Tyr Asp
                245                 250                 255     
Ser Ser Asp Leu Glu Leu Arg Leu Val Gly Gly Thr Asn Arg Cys Met
            260                 265                 270         
Gly Arg Val Glu Leu Lys Ile Gln Gly Arg Trp Gly Thr Val Cys His
        275                 280                 285             
His Lys Trp Asn Asn Ala Ala Ala Asp Val Val Cys Lys Gln Leu Gly
    290                 295                 300                 
Cys Gly Thr Ala Leu His Phe Ala Gly Leu Pro His Leu Gln Ser Gly
305                 310                 315                 320 
Ser Asp Val Val Trp Leu Asp Gly Val Ser Cys Ser Gly Asn Glu Ser
                325                 330                 335     
Phe Leu Trp Asp Cys Arg His Ser Gly Thr Val Asn Phe Asp Cys Leu
            340                 345                 350         
His Gln Asn Asp Val Ser Val Ile Cys Ser Asp Gly Ala Asp Leu Glu
        355                 360                 365             
Leu Arg Leu Ala Asp Gly Ser Asn Asn Cys Ser Gly Arg Val Glu Val
    370                 375                 380                 
Arg Ile His Glu Gln Trp Trp Thr Ile Cys Asp Gln Asn Trp Lys Asn
385                 390                 395                 400 
Glu Gln Ala Leu Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Val
                405                 410                 415     
Phe Gly Ser Arg Arg Ala Lys Pro Ser Asn Glu Ala Arg Asp Ile Trp
            420                 425                 430         
Ile Asn Ser Ile Ser Cys Thr Gly Asn Glu Ser Ala Leu Trp Asp Cys
        435                 440                 445             
Thr Tyr Asp Gly Lys Ala Lys Arg Thr Cys Phe Arg Arg Ser Asp Ala
    450                 455                 460                 
Gly Val Ile Cys Ser Asp Lys Ala Asp Leu Asp Leu Arg Leu Val Gly
465                 470                 475                 480 
Ala His Ser Pro Cys Tyr Gly Arg Leu Glu Val Lys Tyr Gln Gly Glu
                485                 490                 495     
Trp Gly Thr Val Cys His Asp Arg Trp Ser Thr Arg Asn Ala Ala Val
            500                 505                 510         
Val Cys Lys Gln Leu Gly Cys Gly Lys Pro Met His Val Phe Gly Met
        515                 520                 525             
Thr Tyr Phe Lys Glu Ala Ser Gly Pro Ile Trp Leu Asp Asp Val Ser
    530                 535                 540                 
Cys Ile Gly Asn Glu Ser Asn Ile Trp Asp Cys Glu His Ser Gly Trp
545                 550                 555                 560 
Gly Lys His Asn Cys Val His Arg Glu Asp Val Ile Val Thr Cys Ser
                565                 570                 575     
Gly Asp Ala Thr Trp Gly Leu Arg Leu Val Gly Gly Ser Asn Arg Cys
            580                 585                 590         
Ser Gly Arg Leu Glu Val Tyr Phe Gln Gly Arg Trp Gly Thr Val Cys
        595                 600                 605             
Asp Asp Gly Trp Asn Ser Lys Ala Ala Ala Val Val Cys Ser Gln Leu
    610                 615                 620                 
Asp Cys Pro Ser Ser Ile Ile Gly Met Gly Leu Gly Asn Ala Ser Thr
625                 630                 635                 640 
Gly Tyr Gly Lys Ile Trp Leu Asp Asp Val Ser Cys Asp Gly Asp Glu
                645                 650                 655     
Ser Asp Leu Trp Ser Cys Arg Asn Ser Gly Trp Gly Asn Asn Asp Cys
            660                 665                 670         
Ser His Ser Glu Asp Val Gly Val Ile Cys Ser Asp Ala Ser Asp Met
        675                 680                 685             
Glu Leu Arg Leu Val Gly Gly Ser Ser Arg Cys Ala Gly Lys Val Glu
    690                 695                 700                 
Val Asn Val Gln Gly Ala Val Gly Ile Leu Cys Ala Asn Gly Trp Gly
705                 710                 715                 720 
Met Asn Ile Ala Glu Val Val Cys Arg Gln Leu Glu Cys Gly Ser Ala
                725                 730                 735     
Ile Arg Val Ser Arg Glu Pro His Phe Thr Glu Arg Thr Leu His Ile
            740                 745                 750         
Leu Met Ser Asn Ser Gly Cys Thr Gly Gly Glu Ala Ser Leu Trp Asp
        755                 760                 765             
Cys Ile Arg Trp Glu Trp Lys Gln Thr Ala Cys His Leu Asn Met Glu
    770                 775                 780                 
Ala Ser Leu Ile Cys Ser Ala His Arg Gln Pro Arg Leu Val Gly Ala
785                 790                 795                 800 
Asp Met Pro Cys Ser Gly Arg Val Glu Val Lys His Ala Asp Thr Trp
                805                 810                 815     
Arg Ser Val Cys Asp Ser Asp Phe Ser Leu His Ala Ala Asn Val Leu
            820                 825                 830         
Cys Arg Glu Leu Asn Cys Gly Asp Ala Ile Ser Leu Ser Val Gly Asp
        835                 840                 845             
His Phe Gly Lys Gly Asn Gly Leu Thr Trp Ala Glu Lys Phe Gln Cys
    850                 855                 860                 
Glu Gly Ser Glu Thr His Leu Ala Leu Cys Pro Ile Val Gln His Pro
865                 870                 875                 880 
Glu Asp Thr Cys Ile His Ser Arg Glu Val Gly Val Val Cys Ser Arg
                885                 890                 895     
Tyr Thr Asp Val Arg Leu Val Asn Gly Lys Ser Gln Cys Asp Gly Gln
            900                 905                 910         
Val Glu Ile Asn Val Leu Gly His Trp Gly Ser Leu Cys Asp Thr His
        915                 920                 925             
Trp Asp Pro Glu Asp Ala Arg Val Leu Cys Arg Gln Leu Ser Cys Gly
    930                 935                 940                 
Thr Ala Leu Ser Thr Thr Gly Gly Lys Tyr Ile Gly Glu Arg Ser Val
945                 950                 955                 960 
Arg Val Trp Gly His Arg Phe His Cys Leu Gly Asn Glu Ser Leu Leu
                965                 970                 975     
Asp Asn Cys Gln Met Thr Val Leu Gly Ala Pro Pro Cys Ile His Gly
            980                 985                 990         
Asn Thr Val Ser Val Ile Cys Thr Gly Ser Leu Thr Gln Pro Leu Phe
        995                 1000                1005            
Pro Cys Leu Ala Asn Val Ser Asp Pro Tyr Leu Ser Ala Val Pro Glu
    1010                1015                1020                
Gly Ser Ala Leu Ile Cys Leu Glu Asp Lys Arg Leu Arg Leu Val Asp
1025                1030                1035                1040
Gly Asp Ser Arg Cys Ala Gly Arg Val Glu Ile Tyr His Asp Gly Phe
                1045                1050                1055    
Trp Gly Thr Ile Cys Asp Asp Gly Trp Asp Leu Ser Asp Ala His Val
            1060                1065                1070        
Val Cys Gln Lys Leu Gly Cys Gly Val Ala Phe Asn Ala Thr Val Ser
        1075                1080                1085            
Ala His Phe Gly Glu Gly Ser Gly Pro Ile Trp Leu Asp Asp Leu Asn
    1090                1095                1100                
Cys Thr Gly Met Glu Ser His Leu Trp Gln Cys Pro Ser Arg Gly Trp
1105                1110                1115                1120
Gly Gln His Asp Cys Arg His Lys Glu Asp Ala Gly Val Ile Cys Ser
                1125                1130                1135    
Glu Phe Thr Ala Leu Arg Leu Tyr Ser Glu Thr Glu Thr Glu Ser Cys
            1140                1145                1150        
Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Thr Trp Gly Ser Val Gly
        1155                1160                1165            
Arg Arg Asn Ile Thr Thr Ala Ile Ala Gly Ile Val Cys Arg Gln Leu
    1170                1175                1180                
Gly Cys Gly Glu Asn Gly Val Val Ser Leu Ala Pro Leu Ser Lys Thr
1185                1190                1195                1200
Gly Ser Gly Phe Met Trp Val Asp Asp Ile Gln Cys Pro Lys Thr His
                1205                1210                1215    
Ile Ser Ile Trp Gln Cys Leu Ser Ala Pro Trp Glu Arg Arg Ile Ser
            1220                1225                1230        
Ser Thr Ala Glu Glu Thr Trp Ile Thr Cys Glu Asp Arg Ile Arg Val
        1235                1240                1245            
Arg Gly Gly Asp Thr Glu Cys Ser Gly Arg Val Glu Ile Trp His Ala
    1250                1255                1260                
Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu Ala Glu Ala
1265                1270                1275                1280
Glu Val Val Cys Gln Gln Leu Gly Cys Gly Ser Ala Leu Ala Ala Leu
                1285                1290                1295    
Arg Asp Ala Ser Phe Gly Gln Gly Thr Gly Thr Ile Trp Leu Asp Asp
            1300                1305                1310        
Met Arg Cys Lys Gly Asn Glu Ser Phe Leu Trp Asp Cys His Ala Lys
        1315                1320                1325            
Pro Trp Gly Gln Ser Asp Cys Gly His Lys Glu Asp Ala Gly Val Arg
    1330                1335                1340                
Cys Ser Gly Gln Ser Leu Lys Ser Leu Asn Ala Ser Ser Gly Arg Leu
1345                1350                1355                1360
Ala Leu Ile Leu Ser Ser Ile Phe Gly Leu Leu Leu Pro Val Leu Phe
                1365                1370                1375    
Ile Leu Phe Leu Thr Trp Cys Arg Val Gln Lys Gln Lys His Leu Pro
            1380                1385                1390        
Leu Arg Val Ser Thr Arg Arg Arg Gly Ser Leu Glu Glu Asn Leu Phe
        1395                1400                1405            
His Glu Met Glu Thr Cys Leu Lys Arg Glu Asp Pro His Gly Thr Arg
    1410                1415                1420                
Thr Ser Asp Asp Thr Pro Asn His Gly Cys Glu Asp Ala Ser Asp Thr
1425                1430                1435                1440
Ser Leu Leu Gly Val Leu Pro Ala Ser Glu Ala Thr Lys
                1445                1450            


<210> 9448
<211> 620
<212> PRT
<213> Homo sapiens

<400> 9448
Met Leu Ser Ala Ile Tyr Thr Val Leu Ala Gly Leu Leu Phe Leu Pro
 1               5                  10                  15      
Leu Leu Val Asn Leu Cys Cys Pro Tyr Phe Phe Gln Asp Ile Gly Tyr
            20                  25                  30          
Phe Leu Lys Val Ala Ala Val Gly Arg Arg Val Arg Ser Tyr Gly Gln
        35                  40                  45              
Arg Arg Pro Ala Arg Thr Ile Leu Arg Ala Phe Leu Glu Lys Ala Arg
    50                  55                  60                  
Gln Thr Pro His Lys Pro Phe Leu Leu Phe Arg Asp Glu Thr Leu Thr
65                  70                  75                  80  
Tyr Ala Gln Val Asp Arg Arg Ser Asn Gln Val Ala Arg Ala Leu His
                85                  90                  95      
Asp His Leu Gly Leu Arg Gln Gly Asp Cys Val Ala Leu Leu Met Gly
            100                 105                 110         
Asn Glu Pro Ala Tyr Val Trp Leu Trp Leu Gly Leu Val Lys Leu Gly
        115                 120                 125             
Cys Ala Met Ala Cys Leu Asn Tyr Asn Ile Arg Ala Lys Ser Leu Leu
    130                 135                 140                 
His Cys Phe Gln Cys Cys Gly Ala Lys Val Leu Leu Val Ser Pro Glu
145                 150                 155                 160 
Leu Gln Ala Ala Val Glu Glu Ile Leu Pro Ser Leu Lys Lys Asp Asp
                165                 170                 175     
Val Ser Ile Tyr Tyr Val Ser Arg Thr Ser Asn Thr Asp Gly Ile Asp
            180                 185                 190         
Ser Phe Leu Asp Lys Val Asp Glu Val Ser Thr Glu Pro Ile Pro Glu
        195                 200                 205             
Ser Trp Arg Ser Glu Val Thr Phe Ser Thr Pro Ala Leu Tyr Ile Tyr
    210                 215                 220                 
Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Met Ile Thr His Gln
225                 230                 235                 240 
Arg Ile Trp Tyr Gly Thr Gly Leu Thr Phe Val Ser Gly Leu Lys Ala
                245                 250                 255     
Asp Asp Val Ile Tyr Ile Thr Leu Pro Phe Tyr His Ser Ala Ala Leu
            260                 265                 270         
Leu Ile Gly Ile His Gly Cys Ile Val Ala Gly Ala Thr Leu Ala Leu
        275                 280                 285             
Arg Thr Lys Phe Ser Ala Ser Gln Phe Trp Asp Asp Cys Arg Lys Tyr
    290                 295                 300                 
Asn Val Thr Val Ile Gln Tyr Ile Gly Glu Leu Leu Arg Tyr Leu Cys
305                 310                 315                 320 
Asn Ser Pro Gln Lys Pro Asn Asp Arg Asp His Lys Val Arg Leu Ala
                325                 330                 335     
Leu Gly Asn Gly Leu Arg Gly Asp Val Trp Arg Gln Phe Val Lys Arg
            340                 345                 350         
Phe Gly Asp Ile Cys Ile Tyr Glu Phe Tyr Ala Ala Thr Glu Gly Asn
        355                 360                 365             
Ile Gly Phe Met Asn Tyr Ala Arg Lys Val Gly Ala Val Gly Arg Val
    370                 375                 380                 
Asn Tyr Leu Gln Lys Lys Ile Ile Thr Tyr Asp Leu Ile Lys Tyr Asp
385                 390                 395                 400 
Val Glu Lys Asp Glu Pro Val Arg Asp Glu Asn Gly Tyr Cys Val Arg
                405                 410                 415     
Val Pro Lys Gly Glu Val Gly Leu Leu Val Cys Lys Ile Thr Gln Leu
            420                 425                 430         
Thr Pro Phe Asn Gly Tyr Ala Gly Ala Lys Ala Gln Thr Glu Lys Lys
        435                 440                 445             
Lys Leu Arg Asp Val Phe Lys Lys Gly Asp Leu Tyr Phe Asn Ser Gly
    450                 455                 460                 
Asp Leu Leu Met Val Asp His Glu Asn Phe Ile Tyr Phe His Asp Arg
465                 470                 475                 480 
Val Gly Asp Thr Phe Arg Trp Lys Gly Glu Asn Val Ala Thr Thr Glu
                485                 490                 495     
Val Ala Asp Thr Val Gly Leu Val Asp Phe Val Gln Glu Val Asn Val
            500                 505                 510         
Tyr Gly Val His Val Pro Asp His Glu Gly Arg Ile Gly Met Ala Ser
        515                 520                 525             
Ile Lys Met Lys Glu Asn His Glu Phe Asp Gly Lys Lys Leu Phe Gln
    530                 535                 540                 
His Ile Ala Asp Tyr Leu Pro Ser Tyr Ala Arg Pro Arg Phe Leu Arg
545                 550                 555                 560 
Ile Gln Asp Thr Ile Glu Ile Thr Gly Thr Phe Lys His Arg Lys Met
                565                 570                 575     
Thr Leu Val Glu Glu Gly Phe Asn Pro Ala Val Ile Lys Asp Ala Leu
            580                 585                 590         
Tyr Phe Leu Asp Asp Thr Ala Lys Met Tyr Val Pro Met Thr Glu Asp
        595                 600                 605             
Ile Tyr Asn Ala Ile Ser Ala Lys Thr Leu Lys Leu
    610                 615                 620 


<210> 9449
<211> 1151
<212> PRT
<213> Homo sapiens

<400> 9449
Val Leu Cys Cys Tyr Cys Lys Asn Glu Met Ser Gly Pro Ala Gln Val
 1               5                  10                  15      
Pro Met Met Ser Pro Asn Gly Ser Val Pro Pro Ile Tyr Val Pro Pro
            20                  25                  30          
Gly Tyr Ala Pro Gln Val Ile Glu Asp Asn Gly Val Arg Arg Val Val
        35                  40                  45              
Val Val Pro Gln Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu
    50                  55                  60                  
His Arg Ser Pro His Pro Pro Leu Pro Gly Phe Ile Pro Val Pro Thr
65                  70                  75                  80  
Met Met Pro Pro Pro Pro Arg His Met Tyr Ser Pro Val Thr Gly Ala
                85                  90                  95      
Gly Asp Met Thr Thr Gln Tyr Met Pro Gln Tyr Gln Ser Ser Gln Val
            100                 105                 110         
Tyr Gly Asp Val Asp Ala His Ser Thr His Gly Arg Ser Asn Phe Arg
        115                 120                 125             
Asp Glu Arg Ser Ser Lys Thr Tyr Glu Arg Leu Gln Lys Lys Leu Lys
    130                 135                 140                 
Asp Arg Gln Gly Thr Gln Lys Asp Lys Met Ser Ser Pro Pro Ser Ser
145                 150                 155                 160 
Pro Gln Lys Cys Pro Ser Pro Ile Asn Glu His Asn Gly Leu Ile Lys
                165                 170                 175     
Gly Gln Ile Ala Gly Gly Ile Asn Thr Gly Ser Ala Lys Ile Lys Ser
            180                 185                 190         
Gly Lys Gly Lys Gly Gly Thr Gln Val Asp Thr Glu Ile Glu Glu Lys
        195                 200                 205             
Asp Glu Glu Thr Lys Ala Phe Glu Ala Leu Leu Ser Asn Ile Val Lys
    210                 215                 220                 
Pro Val Ala Ser Asp Ile Gln Ala Arg Thr Val Val Leu Thr Trp Ser
225                 230                 235                 240 
Pro Pro Ser Ser Leu Ile Asn Gly Glu Thr Asp Glu Ser Ser Val Pro
                245                 250                 255     
Glu Leu Tyr Gly Tyr Glu Val Leu Ile Ser Ser Thr Gly Lys Asp Gly
            260                 265                 270         
Lys Tyr Lys Ser Val Tyr Val Gly Glu Glu Thr Asn Ile Thr Leu Asn
        275                 280                 285             
Asp Leu Lys Pro Ala Met Asp Tyr His Ala Lys Val Gln Ala Glu Tyr
    290                 295                 300                 
Asn Ser Ile Lys Gly Thr Pro Ser Glu Ala Glu Ile Phe Thr Thr Leu
305                 310                 315                 320 
Ser Cys Glu Pro Asp Ile Pro Asn Pro Pro Arg Ile Ala Asn Arg Thr
                325                 330                 335     
Lys Asn Ser Leu Thr Leu Gln Trp Lys Ala Pro Ser Asp Asn Gly Ser
            340                 345                 350         
Lys Ile Gln Asn Phe Val Leu Glu Trp Asp Glu Gly Lys Gly Asn Gly
        355                 360                 365             
Glu Phe Cys Gln Cys Tyr Met Gly Ser Gln Lys Gln Phe Lys Ile Thr
    370                 375                 380                 
Lys Leu Ser Pro Ala Met Gly Cys Lys Phe Arg Leu Ser Ala Arg Asn
385                 390                 395                 400 
Asp Tyr Gly Thr Ser Gly Phe Ser Glu Glu Val Leu Tyr Tyr Thr Ser
                405                 410                 415     
Gly Cys Ala Pro Ser Met Pro Ala Ser Pro Val Leu Thr Lys Ala Gly
            420                 425                 430         
Ile Thr Trp Leu Ser Leu Gln Trp Ser Lys Pro Ser Gly Thr Pro Ser
        435                 440                 445             
Asp Glu Gly Ile Ser Tyr Ile Leu Glu Met Glu Glu Glu Thr Ser Gly
    450                 455                 460                 
Tyr Gly Phe Lys Pro Lys Tyr Asp Gly Glu Asp Leu Ala Tyr Thr Val
465                 470                 475                 480 
Lys Asn Leu Arg Arg Ser Thr Lys Tyr Lys Phe Lys Val Ile Ala Tyr
                485                 490                 495     
Asn Ser Glu Gly Lys Ser Asn Pro Ser Glu Val Val Glu Phe Thr Thr
            500                 505                 510         
Cys Pro Asp Lys Pro Gly Ile Pro Val Lys Pro Ser Val Lys Gly Lys
        515                 520                 525             
Ile His Ser His Ser Phe Lys Ile Thr Trp Asp Pro Pro Lys Asp Asn
    530                 535                 540                 
Gly Gly Ala Thr Ile Asn Lys Tyr Val Val Glu Met Ala Glu Gly Ser
545                 550                 555                 560 
Asn Gly Asn Lys Trp Glu Met Ile Tyr Ser Gly Ala Thr Arg Glu His
                565                 570                 575     
Leu Cys Asp Arg Leu Asn Pro Gly Cys Phe Tyr Arg Leu Arg Val Tyr
            580                 585                 590         
Cys Ile Ser Asp Gly Gly Gln Ser Ala Val Ser Glu Ser Leu Leu Val
        595                 600                 605             
Gln Thr Pro Ala Val Pro Pro Gly Pro Cys Leu Pro Pro Arg Leu Gln
    610                 615                 620                 
Gly Arg Pro Lys Ala Lys Glu Ile Gln Leu Arg Trp Gly Pro Pro Leu
625                 630                 635                 640 
Val Asp Gly Gly Ser Pro Ile Ser Cys Tyr Ser Val Glu Met Ser Pro
                645                 650                 655     
Ile Glu Lys Asp Glu Pro Arg Glu Val Tyr Gln Gly Ser Glu Val Glu
            660                 665                 670         
Cys Thr Val Ser Ser Leu Leu Pro Gly Lys Thr Tyr Ser Phe Arg Leu
        675                 680                 685             
Arg Ala Ala Asn Lys Met Gly Phe Gly Pro Phe Ser Glu Lys Cys Asp
    690                 695                 700                 
Ile Thr Thr Ala Pro Gly Pro Pro Asp Gln Cys Lys Pro Pro Gln Val
705                 710                 715                 720 
Thr Cys Arg Ser Ala Thr Cys Ala Gln Val Asn Trp Glu Val Pro Leu
                725                 730                 735     
Ser Asn Gly Thr Asp Val Thr Glu Tyr Arg Leu Glu Trp Gly Gly Val
            740                 745                 750         
Glu Gly Ser Met Gln Ile Cys Tyr Cys Gly Pro Gly Leu Ser Tyr Glu
        755                 760                 765             
Ile Lys Gly Leu Ser Pro Ala Thr Thr Tyr Tyr Cys Arg Val Gln Ala
    770                 775                 780                 
Leu Ser Val Val Gly Ala Gly Pro Phe Ser Glu Val Val Ala Cys Val
785                 790                 795                 800 
Thr Pro Pro Ser Val Pro Gly Ile Val Thr Cys Leu Gln Glu Ile Ser
                805                 810                 815     
Asp Asp Glu Ile Glu Asn Pro His Tyr Ser Pro Ser Thr Cys Leu Ala
            820                 825                 830         
Ile Ser Trp Glu Lys Pro Cys Asp His Gly Ser Glu Ile Leu Ala Tyr
        835                 840                 845             
Ser Ile Asp Phe Gly Asp Lys Gln Ser Leu Thr Val Gly Lys Val Thr
    850                 855                 860                 
Ser Tyr Ile Ile Asn Asn Leu Gln Pro Asp Thr Thr Tyr Arg Ile Arg
865                 870                 875                 880 
Ile Gln Ala Leu Asn Ser Leu Gly Ala Gly Pro Phe Ser His Met Ile
                885                 890                 895     
Lys Leu Lys Thr Lys Pro Leu Pro Pro Asp Pro Pro Arg Leu Glu Cys
            900                 905                 910         
Val Ala Phe Ser His Gln Asn Leu Lys Leu Lys Trp Gly Glu Gly Thr
        915                 920                 925             
Pro Lys Thr Leu Ser Thr Asp Ser Ile Gln Tyr His Leu Gln Met Glu
    930                 935                 940                 
Asp Lys Asn Gly Arg Phe Val Ser Leu Tyr Arg Gly Pro Cys His Thr
945                 950                 955                 960 
Tyr Lys Val Gln Arg Leu Asn Glu Ser Thr Ser Tyr Lys Phe Cys Ile
                965                 970                 975     
Gln Ala Cys Asn Glu Ala Gly Glu Gly Pro Leu Ser Gln Glu Tyr Ile
            980                 985                 990         
Phe Thr Thr Pro Lys Ser Val Pro Ala Ala Leu Lys Ala Pro Lys Ile
        995                 1000                1005            
Glu Lys Val Asn Asp His Ile Cys Glu Ile Thr Trp Glu Cys Leu Gln
    1010                1015                1020                
Pro Met Lys Gly Asp Pro Val Ile Tyr Ser Leu Gln Val Met Leu Gly
1025                1030                1035                1040
Lys Asp Ser Glu Phe Lys Gln Ile Tyr Lys Gly Pro Asp Ser Ser Phe
                1045                1050                1055    
Arg Tyr Ser Ser Leu Gln Leu Asn Cys Glu Tyr Arg Phe Arg Val Cys
            1060                1065                1070        
Ala Ile Arg Gln Cys Gln Asp Ser Leu Gly His Gln Asp Leu Val Gly
        1075                1080                1085            
Pro Tyr Ser Thr Thr Val Leu Phe Ile Ser Gln Arg Thr Glu Pro Pro
    1090                1095                1100                
Ala Ser Thr Asn Arg Asp Thr Val Glu Ser Thr Arg Thr Arg Arg Ala
1105                1110                1115                1120
Leu Ser Asp Glu Gln Cys Ala Ala Val Ile Leu Val Leu Phe Ala Phe
                1125                1130                1135    
Phe Ser Ile Leu Ile Ala Phe Ile Ile Gln Tyr Phe Val Ile Lys
            1140                1145                1150    


<210> 9450
<211> 988
<212> PRT
<213> Homo sapiens

<400> 9450
Met Cys Val Thr Lys Lys Leu Phe Phe Ile Val Gln Arg Thr Ile Phe
 1               5                  10                  15      
Val Gly Cys Val Ile Trp Lys Phe Cys Leu His Tyr Val Leu Arg Gly
            20                  25                  30          
Phe Leu Cys Phe Asn Ser Met Gln Leu Asp Arg Asn Thr Leu Pro Lys
        35                  40                  45              
Lys Gly Leu Arg Tyr Thr Pro Ser Ser Arg Gln Ala Asn Gln Glu Glu
    50                  55                  60                  
Gly Lys Glu Trp Leu Arg Ser His Ser Thr Gly Gly Leu Gln Asp Thr
65                  70                  75                  80  
Gly Asn Gln Ser Pro Leu Val Ser Pro Ser Ala Met Ser Ser Ser Ala
                85                  90                  95      
Ala Gly Lys Tyr His Phe Ser Asn Leu Val Ser Pro Thr Asn Leu Ser
            100                 105                 110         
Gln Phe Asn Leu Pro Gly Pro Ser Met Met Arg Ser Asn Ser Ile Pro
        115                 120                 125             
Ala Gln Asp Ser Ser Phe Asp Leu Tyr Asp Asp Ser Gln Leu Cys Gly
    130                 135                 140                 
Ser Ala Thr Ser Leu Glu Glu Arg Pro Arg Ala Ile Ser His Ser Gly
145                 150                 155                 160 
Ser Phe Arg Asp Ser Met Glu Glu Val His Gly Ser Ser Leu Ser Leu
                165                 170                 175     
Val Ser Ser Thr Ser Ser Leu Tyr Ser Thr Ala Glu Glu Lys Ala His
            180                 185                 190         
Ser Glu Gln Ile His Lys Leu Arg Arg Glu Leu Val Ala Ser Gln Glu
        195                 200                 205             
Lys Val Ala Thr Leu Thr Ser Gln Leu Ser Ala Asn Ala His Leu Val
    210                 215                 220                 
Ala Ala Phe Glu Lys Ser Leu Gly Asn Met Thr Gly Arg Leu Gln Ser
225                 230                 235                 240 
Leu Thr Met Thr Ala Glu Gln Lys Glu Ser Glu Leu Ile Glu Leu Arg
                245                 250                 255     
Glu Thr Ile Glu Met Leu Lys Ala Gln Asn Ser Ala Ala Gln Ala Ala
            260                 265                 270         
Ile Gln Gly Ala Leu Asn Gly Pro Asp His Pro Pro Lys Asp Leu Arg
        275                 280                 285             
Ile Arg Arg Gln His Ser Ser Glu Ser Val Ser Ser Ile Asn Ser Ala
    290                 295                 300                 
Thr Ser His Ser Ser Ile Gly Ser Gly Asn Asp Ala Asp Ser Lys Lys
305                 310                 315                 320 
Lys Lys Lys Lys Asn Trp Val Asn Ser Arg Gly Ser Glu Leu Arg Ser
                325                 330                 335     
Ser Phe Lys Gln Ala Phe Gly Lys Lys Lys Ser Thr Lys Pro Pro Ser
            340                 345                 350         
Ser His Ser Asp Ile Glu Glu Leu Thr Asp Ser Ser Leu Pro Ala Ser
        355                 360                 365             
Pro Lys Leu Pro His Asn Ala Gly Asp Cys Gly Ser Ala Ser Met Lys
    370                 375                 380                 
Pro Ser Gln Ser Ala Ser Ala Ile Cys Glu Cys Thr Glu Ala Glu Ala
385                 390                 395                 400 
Glu Ile Ile Leu Gln Leu Lys Ser Glu Leu Arg Glu Lys Glu Leu Lys
                405                 410                 415     
Leu Thr Asp Ile Arg Leu Glu Ala Leu Ser Ser Ala His His Leu Asp
            420                 425                 430         
Gln Ile Arg Glu Ala Met Asn Arg Met Gln Asn Glu Ile Glu Ile Leu
        435                 440                 445             
Lys Ala Glu Asn Asp Arg Leu Lys Ala Glu Thr Gly Asn Thr Ala Lys
    450                 455                 460                 
Pro Thr Arg Pro Pro Ser Glu Ser Ser Ser Ser Thr Ser Ser Ser Ser
465                 470                 475                 480 
Ser Arg Gln Ser Leu Gly Leu Ser Leu Asn Asn Leu Asn Ile Thr Glu
                485                 490                 495     
Ala Val Ser Ser Asp Ile Leu Leu Asp Asp Ala Gly Asp Ala Thr Gly
            500                 505                 510         
His Lys Asp Gly Arg Ser Val Lys Ile Ile Val Ser Ile Ser Lys Gly
        515                 520                 525             
Tyr Gly Arg Ala Lys Asp Gln Lys Ser Gln Ala Tyr Leu Ile Gly Ser
    530                 535                 540                 
Ile Gly Val Ser Gly Lys Thr Lys Trp Asp Val Leu Asp Gly Val Ile
545                 550                 555                 560 
Arg Arg Leu Phe Lys Glu Tyr Val Phe Arg Ile Asp Thr Ser Thr Ser
                565                 570                 575     
Leu Gly Leu Ser Ser Asp Cys Ile Ala Ser Tyr Cys Ile Gly Asp Leu
            580                 585                 590         
Ile Arg Ser His Asn Leu Glu Val Pro Glu Leu Leu Pro Cys Gly Tyr
        595                 600                 605             
Leu Val Gly Asp Asn Asn Ile Ile Thr Val Asn Leu Lys Gly Val Glu
    610                 615                 620                 
Glu Asn Ser Leu Asp Ser Phe Val Phe Asp Thr Leu Ile Pro Lys Pro
625                 630                 635                 640 
Ile Thr Gln Arg Tyr Phe Asn Leu Leu Met Glu His His Arg Ile Ile
                645                 650                 655     
Leu Ser Gly Pro Ser Gly Thr Gly Lys Thr Tyr Leu Ala Asn Lys Leu
            660                 665                 670         
Ala Glu Tyr Val Ile Thr Lys Ser Gly Arg Lys Lys Thr Glu Asp Ala
        675                 680                 685             
Ile Ala Thr Phe Asn Val Asp His Lys Ser Ser Lys Glu Leu Gln Gln
    690                 695                 700                 
Tyr Leu Ala Asn Leu Ala Glu Gln Cys Ser Ala Asp Asn Asn Gly Val
705                 710                 715                 720 
Glu Leu Pro Val Val Ile Ile Leu Asp Asn Leu His His Val Gly Ser
                725                 730                 735     
Leu Ser Asp Ile Phe Asn Gly Phe Leu Asn Cys Lys Tyr Asn Lys Cys
            740                 745                 750         
Pro Tyr Ile Ile Gly Thr Met Asn Gln Gly Val Ser Ser Ser Pro Asn
        755                 760                 765             
Leu Glu Leu His His Asn Phe Arg Trp Val Leu Cys Ala Asn His Thr
    770                 775                 780                 
Glu Pro Val Lys Gly Phe Leu Gly Arg Tyr Leu Arg Arg Lys Leu Ile
785                 790                 795                 800 
Glu Ile Glu Ile Glu Arg Asn Ile Arg Asn Asn Asp Leu Val Lys Ile
                805                 810                 815     
Ile Asp Trp Ile Pro Lys Thr Trp His His Leu Asn Ser Phe Leu Glu
            820                 825                 830         
Thr His Ser Ser Ser Asp Val Thr Ile Gly Pro Arg Leu Phe Leu Pro
        835                 840                 845             
Cys Pro Met Asp Val Glu Gly Ser Arg Val Trp Phe Met Asp Leu Trp
    850                 855                 860                 
Asn Tyr Ser Leu Val Pro Tyr Ile Leu Glu Ala Val Arg Glu Gly Leu
865                 870                 875                 880 
Gln Met Tyr Gly Lys Arg Thr Pro Trp Glu Asp Pro Ser Lys Trp Val
                885                 890                 895     
Leu Asp Thr Tyr Pro Trp Ser Ser Ala Thr Leu Pro Gln Glu Ser Pro
            900                 905                 910         
Ala Leu Leu Gln Leu Arg Pro Glu Asp Val Gly Tyr Glu Ser Cys Thr
        915                 920                 925             
Ser Thr Lys Glu Ala Thr Thr Ser Lys His Ile Pro Gln Thr Asp Thr
    930                 935                 940                 
Glu Gly Asp Pro Leu Met Asn Met Leu Met Lys Leu Gln Glu Ala Ala
945                 950                 955                 960 
Asn Tyr Ser Ser Thr Gln Ser Cys Asp Ser Glu Ser Thr Ser His His
                965                 970                 975     
Glu Asp Ile Leu Asp Ser Ser Leu Glu Ser Thr Leu
            980                 985             


<210> 9451
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 9451
Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu
 1               5                  10                  15      
Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val
            20                  25                  30          
Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu Tyr
        35                  40                  45              
Trp Met Pro Glu Trp Arg Val Lys Ala Thr Cys Val Arg Ala Ala Ile
    50                  55                  60                  
Lys Asp Cys Glu Val Val Leu Leu Arg Thr Thr Asp Glu Phe Lys Met
65                  70                  75                  80  
Trp Phe Cys Ala Lys Ile Arg Val Leu Ser Leu Glu Thr Tyr Pro Val
                85                  90                  95      
Ser Ser Pro Lys Ser Met Ser Asn Lys Leu Ser Asn Gly His Ala Val
            100                 105                 110         
Cys Leu Ile Glu Asn Pro Thr Glu Glu Asn Arg His Arg Ile Ser Lys
        115                 120                 125             
Tyr Ser Gln Thr Glu Ser Gln Gln Ile Arg Tyr Phe Thr His His Ser
    130                 135                 140                 
Val Lys Tyr Phe Trp Asn Asp Thr Ile His Asn Phe Asp Phe Leu Lys
145                 150                 155                 160 
Gly Leu Asp Glu Gly Val Ser Cys Thr Ser Ile Tyr Glu Lys His Ser
                165                 170                 175     
Ala Gly Leu Thr Lys Gly Met His Ala Tyr Arg Lys Leu Leu Tyr Gly
            180                 185                 190         
Val Asn Glu Ile Ala Val Lys Val Pro Ser Val Phe Lys Leu Leu Ile
        195                 200                 205             
Lys Glu Val Leu Asn Pro Phe Tyr Ile Phe Gln Leu Phe Ser Val Ile
    210                 215                 220                 
Leu Trp Ser Thr Asp Glu Tyr Tyr Tyr Tyr Ala Leu Ala Ile Val Val
225                 230                 235                 240 
Met Ser Ile Val Ser Ile Val Ser Ser Leu Tyr Ser Ile Arg Lys Gln
                245                 250                 255     
Tyr Val Met Leu His Asp Met Val Ala Thr His Ser Thr Val Arg Val
            260                 265                 270         
Ser Val Cys Arg Val Asn Glu Glu Ile Glu Glu Ile Phe Ser Thr Asp
        275                 280                 285             
Leu Val Pro Gly Asp Val Met Val Ile Pro Leu Asn Gly Thr Ile Met
    290                 295                 300                 
Pro Cys Asp Ala Val Leu Ile Asn Gly Thr Cys Ile Val Asn Glu Ser
305                 310                 315                 320 
Met Leu Thr Gly Glu Ser Val Pro Val Thr Lys Thr Asn Leu Pro Asn
                325                 330                 335     
Pro Ser Val Asp Val Lys Gly Ile Gly Asp Glu Leu Tyr Asn Pro Glu
            340                 345                 350         
Thr His Lys Arg His Thr Leu Phe Cys Gly Thr Thr Val Ile Gln Thr
        355                 360                 365             
Arg Phe Tyr Thr Gly Glu Leu Val Lys Ala Ile Val Val Arg Thr Gly
    370                 375                 380                 
Phe Ser Thr Ser Lys Gly Gln Leu Val Arg Ser Ile Leu Tyr Pro Lys
385                 390                 395                 400 
Pro Thr Asp Phe Lys Leu Tyr Arg Asp Ala Tyr Leu Phe Leu Leu Cys
                405                 410                 415     
Leu Val Ala Val Ala Gly Ile Gly Phe Ile Tyr Thr Ile Ile Asn Ser
            420                 425                 430         
Ile Leu Asn Glu Val Gln Val Gly Val Ile Ile Ile Glu Ser Leu Asp
        435                 440                 445             
Ile Ile Thr Ile Thr Val Pro Pro Ala Leu Pro Ala Ala Met Thr Ala
    450                 455                 460                 
Gly Ile Val Tyr Ala Gln Arg Arg Leu Lys Lys Ile Gly Ile Phe Cys
465                 470                 475                 480 
Ile Ser Pro Gln Arg Ile Asn Ile Cys Gly Gln Leu Asn Leu Val Cys
                485                 490                 495     
Phe Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Leu Trp Gly
            500                 505                 510         
Ile Gln Arg Val Glu Asn Ala Arg Phe Leu Ser Pro Glu Glu Asn Val
        515                 520                 525             
Cys Asn Glu Met Leu Val Lys Ser Gln Phe Val Ala Cys Met Ala Thr
    530                 535                 540                 
Cys His Ser Leu Thr Lys Ile Glu Gly Val Leu Ser Gly Asp Pro Leu
545                 550                 555                 560 
Asp Leu Lys Met Phe Glu Ala Ile Gly Trp Ile Leu Glu Glu Ala Thr
                565                 570                 575     
Glu Glu Glu Thr Ala Leu His Asn Arg Ile Met Pro Thr Val Val Arg
            580                 585                 590         
Pro Pro Lys Gln Leu Leu Pro Glu Ser Thr Pro Ala Gly Asn Gln Glu
        595                 600                 605             
Met Glu Leu Phe Glu Leu Pro Ala Thr Tyr Glu Ile Gly Ile Val Arg
    610                 615                 620                 
Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val Ala Arg
625                 630                 635                 640 
Val Leu Gly Asp Arg Lys Met Asp Ala Tyr Met Lys Gly Ala Pro Glu
                645                 650                 655     
Ala Ile Ala Gly Leu Cys Lys Pro Glu Thr Val Pro Val Asp Phe Gln
            660                 665                 670         
Asn Val Leu Glu Asp Phe Thr Lys Gln Gly Phe Arg Val Ile Ala Leu
        675                 680                 685             
Ala His Arg Lys Leu Glu Ser Lys Leu Thr Trp His Lys Val Gln Asn
    690                 695                 700                 
Ile Ser Arg Asp Ala Ile Glu Asn Asn Met Asp Phe Met Gly Leu Ile
705                 710                 715                 720 
Ile Met Gln Asn Lys Leu Lys Gln Glu Thr Pro Ala Val Leu Glu Asp
                725                 730                 735     
Leu His Lys Ala Asn Ile Arg Thr Val Met Val Thr Gly Asp Ser Met
            740                 745                 750         
Leu Thr Ala Val Ser Val Ala Arg Asp Cys Gly Met Ile Leu Pro Gln
        755                 760                 765             
Asp Lys Val Ile Ile Ala Glu Ala Leu Pro Pro Lys Asp Gly Lys Val
    770                 775                 780                 
Ala Lys Ile Asn Trp His Tyr Ala Asp Ser Leu Thr Gln Cys Ser His
785                 790                 795                 800 
Pro Ser Ala Ile Asp Pro Glu Ala Ile Pro Val Lys Leu Val His Asp
                805                 810                 815     
Ser Leu Glu Asp Leu Gln Met Thr Arg Tyr His Phe Ala Met Asn Gly
            820                 825                 830         
Lys Ser Phe Ser Val Ile Leu Glu His Phe Gln Asp Leu Val Pro Lys
        835                 840                 845             
Leu Met Leu His Gly Thr Val Phe Ala Arg Met Ala Pro Asp Gln Lys
    850                 855                 860                 
Thr Gln Leu Ile Glu Ala Leu Gln Asn Val Asp Tyr Phe Val Gly Met
865                 870                 875                 880 
Cys Gly Asp Gly Ala Asn Asp Cys Gly Ala Leu Lys Arg Ala His Gly
                885                 890                 895     
Gly Ile Ser Leu Ser Glu Leu Glu Ala Ser Val Ala Ser Pro Phe Thr
            900                 905                 910         
Ser Lys Thr Pro Ser Ile Ser Cys Val Pro Asn Leu Ile Arg Glu Gly
        915                 920                 925             
Arg Ala Ala Leu Ile Thr Ser Phe Cys Val Phe Lys Phe Met Ala Leu
    930                 935                 940                 
Tyr Ser Ile Ile Gln Tyr Phe Ser Val Thr Leu Leu Tyr Ser Ile Leu
945                 950                 955                 960 
Ser Asn Leu Gly Asp Phe Gln Phe Leu Phe Ile Asp Leu Ala Ile Ile
                965                 970                 975     
Leu Val Val Val Phe Thr Met Ser Leu Asn Pro Ala Trp Lys Glu Leu
            980                 985                 990         
Val Ala Gln Arg Pro Pro Ser Gly Leu Ile Ser Gly Ala Leu Leu Phe
        995                 1000                1005            
Ser Val Leu Ser Gln Ile Ile Ile Cys Ile Gly Phe Gln Ser Leu Gly
    1010                1015                1020                
Phe Phe Trp Val Lys Gln Gln Pro Trp Tyr Glu Val Trp His Pro Lys
1025                1030                1035                1040
Ser Asp Ala Cys Asn Thr Thr Gly Ser Gly Phe Trp Asn Ser Ser His
                1045                1050                1055    
Val Asp Asn Glu Thr Glu Leu Asp Glu His Asn Ile Gln Asn Tyr Glu
            1060                1065                1070        
Asn Thr Thr Val Phe Phe Ile Ser Ser Phe Gln Tyr Leu Ile Val Ala
        1075                1080                1085            
Ile Ala Phe Ser Lys Gly Lys Pro Phe Arg Gln Pro Cys Tyr Lys Asn
    1090                1095                1100                
Tyr Phe Phe Val Phe Ser Val Ile Phe Leu Tyr Ile Phe Ile Leu Phe
1105                1110                1115                1120
Ile Met Leu Tyr Pro Val Ala Ser Val Asp
                1125                1130


<210> 9452
<211> 2035
<212> PRT
<213> Homo sapiens

<400> 9452
Met Asp Leu Arg Pro Glu Leu Pro Thr Thr Leu Gly Pro Val Ser Leu
 1               5                  10                  15      
Arg Gln Leu Gly Leu Glu His Thr Arg Tyr Pro Cys Leu Asp Leu Gly
            20                  25                  30          
Ala Met Leu Leu Tyr Thr Leu Thr Phe Trp Leu Leu Leu Arg Gln Phe
        35                  40                  45              
Val Lys Glu Lys Leu Leu Lys Trp Ala Glu Ser Pro Ala Ala Leu Thr
    50                  55                  60                  
Glu Val Thr Val Ala Asp Thr Glu Pro Thr Arg Thr Gln Thr Leu Leu
65                  70                  75                  80  
Gln Ser Leu Gly Glu Leu Val Lys Gly Val Tyr Ala Lys Tyr Trp Ile
                85                  90                  95      
Tyr Val Cys Ala Gly Met Phe Ile Val Val Ser Phe Ala Gly Arg Leu
            100                 105                 110         
Val Val Tyr Lys Ile Val Tyr Met Phe Leu Phe Leu Leu Cys Leu Thr
        115                 120                 125             
Leu Phe Gln Val Tyr Tyr Ser Leu Trp Arg Lys Leu Leu Lys Ala Phe
    130                 135                 140                 
Trp Trp Leu Val Val Ala Tyr Thr Met Leu Val Leu Ile Ala Val Tyr
145                 150                 155                 160 
Thr Phe Gln Phe Gln Asp Phe Pro Ala Tyr Trp Arg Asn Leu Thr Gly
                165                 170                 175     
Phe Thr Asp Glu Gln Leu Gly Asp Leu Gly Leu Glu Gln Phe Ser Val
            180                 185                 190         
Ser Glu Leu Phe Ser Ser Ile Leu Val Pro Gly Phe Phe Leu Leu Ala
        195                 200                 205             
Cys Ile Leu Gln Leu His Tyr Phe His Arg Pro Phe Met Gln Leu Thr
    210                 215                 220                 
Asp Met Glu His Val Ser Leu Pro Gly Thr Arg Leu Pro Arg Trp Ala
225                 230                 235                 240 
His Arg Gln Asp Ala Val Ser Gly Thr Pro Leu Leu Arg Glu Glu Gln
                245                 250                 255     
Gln Glu His Gln Gln Gln Gln Gln Glu Glu Glu Glu Glu Glu Asp Ser
            260                 265                 270         
Arg Asp Glu Gly Leu Gly Val Ala Thr Pro His Gln Ala Thr Gln Val
        275                 280                 285             
Pro Glu Gly Ala Ala Lys Trp Gly Leu Val Ala Glu Arg Leu Leu Glu
    290                 295                 300                 
Leu Ala Ala Gly Phe Ser Asp Val Leu Ser Arg Val Gln Val Phe Leu
305                 310                 315                 320 
Arg Arg Leu Leu Glu Leu His Val Phe Lys Leu Val Ala Leu Tyr Thr
                325                 330                 335     
Val Trp Val Ala Leu Lys Glu Val Ser Val Met Asn Leu Leu Leu Val
            340                 345                 350         
Val Leu Trp Ala Phe Ala Leu Pro Tyr Pro Arg Phe Arg Pro Met Ala
        355                 360                 365             
Ser Cys Leu Ser Thr Val Trp Thr Cys Val Ile Ile Val Cys Lys Met
    370                 375                 380                 
Leu Tyr Gln Leu Lys Val Val Asn Pro Gln Glu Tyr Ser Ser Asn Cys
385                 390                 395                 400 
Thr Glu Pro Phe Pro Asn Ser Thr Asn Leu Leu Pro Thr Glu Ile Ser
                405                 410                 415     
Gln Ser Leu Leu Tyr Arg Gly Pro Val Asp Pro Ala Asn Trp Phe Gly
            420                 425                 430         
Val Arg Lys Gly Phe Pro Asn Leu Gly Tyr Ile Gln Asn His Leu Gln
        435                 440                 445             
Val Leu Leu Leu Leu Val Phe Glu Ala Ile Val Tyr Arg Arg Gln Glu
    450                 455                 460                 
His Tyr Arg Arg Gln His Gln Leu Ala Pro Leu Pro Ala Gln Ala Val
465                 470                 475                 480 
Phe Ala Ser Gly Thr Arg Gln Gln Leu Asp Gln Asp Leu Leu Gly Cys
                485                 490                 495     
Leu Lys Tyr Phe Ile Asn Phe Phe Phe Tyr Lys Phe Gly Leu Glu Ile
            500                 505                 510         
Cys Phe Leu Met Ala Val Asn Val Ile Gly Gln Arg Met Asn Phe Leu
        515                 520                 525             
Val Thr Leu His Gly Cys Trp Leu Val Ala Ile Leu Thr Arg Arg His
    530                 535                 540                 
Arg Gln Ala Ile Ala Arg Leu Trp Pro Asn Tyr Cys Leu Phe Leu Ala
545                 550                 555                 560 
Leu Phe Leu Leu Tyr Gln Tyr Leu Leu Cys Leu Gly Met Pro Pro Ala
                565                 570                 575     
Leu Cys Ile Asp Tyr Pro Trp Arg Trp Ser Arg Ala Val Pro Met Asn
            580                 585                 590         
Ser Ala Leu Ile Lys Trp Leu Tyr Leu Pro Asp Phe Phe Arg Ala Pro
        595                 600                 605             
Asn Ser Thr Asn Leu Ile Ser Asp Phe Leu Leu Leu Leu Cys Ala Ser
    610                 615                 620                 
Gln Gln Trp Gln Val Phe Ser Ala Glu Arg Thr Glu Glu Trp Gln Arg
625                 630                 635                 640 
Met Ala Gly Val Asn Thr Asp Arg Leu Glu Pro Leu Arg Gly Glu Pro
                645                 650                 655     
Asn Pro Val Pro Asn Phe Ile His Cys Arg Ser Tyr Leu Asp Met Leu
            660                 665                 670         
Lys Val Ala Val Phe Arg Tyr Leu Phe Trp Leu Val Leu Val Val Val
        675                 680                 685             
Phe Val Thr Gly Ala Thr Arg Ile Ser Ile Phe Gly Leu Gly Tyr Leu
    690                 695                 700                 
Leu Ala Cys Phe Tyr Leu Leu Leu Phe Gly Thr Ala Leu Leu Gln Arg
705                 710                 715                 720 
Asp Thr Arg Ala Arg Leu Val Leu Trp Asp Cys Leu Ile Leu Tyr Asn
                725                 730                 735     
Val Thr Val Ile Ile Ser Lys Asn Met Leu Ser Leu Leu Ala Cys Val
            740                 745                 750         
Phe Val Glu Gln Met Gln Thr Gly Phe Cys Trp Val Ile Gln Leu Phe
        755                 760                 765             
Ser Leu Val Cys Thr Val Lys Gly Tyr Tyr Asp Pro Lys Glu Met Met
    770                 775                 780                 
Asp Arg Asp Gln Asp Cys Leu Leu Pro Val Glu Glu Ala Gly Ile Ile
785                 790                 795                 800 
Trp Asp Ser Val Cys Phe Phe Phe Leu Leu Leu Gln Arg Arg Val Phe
                805                 810                 815     
Leu Ser His Tyr Tyr Leu His Val Arg Ala Asp Leu Gln Ala Thr Ala
            820                 825                 830         
Leu Leu Ala Ser Arg Gly Phe Ala Leu Tyr Asn Ala Ala Asn Leu Lys
        835                 840                 845             
Ser Ile Asp Phe His Arg Arg Ile Glu Glu Lys Ser Leu Ala Gln Leu
    850                 855                 860                 
Lys Arg Gln Met Glu Arg Ile Arg Ala Lys Gln Glu Lys His Arg Gln
865                 870                 875                 880 
Gly Arg Val Asp Arg Ser Arg Pro Gln Asp Thr Leu Gly Pro Lys Asp
                885                 890                 895     
Pro Gly Leu Glu Pro Gly Pro Asp Ser Pro Gly Gly Ser Ser Pro Pro
            900                 905                 910         
Arg Arg Gln Trp Trp Arg Pro Trp Leu Asp His Ala Thr Val Ile His
        915                 920                 925             
Ser Gly Asp Tyr Phe Leu Phe Glu Ser Asp Ser Glu Glu Glu Glu Glu
    930                 935                 940                 
Ala Val Pro Glu Asp Pro Arg Pro Ser Ala Gln Ser Ala Phe Gln Leu
945                 950                 955                 960 
Ala Tyr Gln Ala Trp Val Thr Asn Ala Gln Ala Val Leu Arg Arg Arg
                965                 970                 975     
Gln Gln Glu Gln Glu Gln Ala Arg Gln Glu Gln Ala Gly Gln Leu Pro
            980                 985                 990         
Thr Gly Gly Gly Pro Ser Gln Glu Val Glu Pro Ala Glu Gly Pro Glu
        995                 1000                1005            
Glu Ala Ala Ala Gly Arg Ser His Val Val Gln Arg Val Leu Ser Thr
    1010                1015                1020                
Ala Gln Phe Leu Trp Met Leu Gly Gln Ala Leu Val Asp Glu Leu Thr
1025                1030                1035                1040
Arg Trp Leu Gln Glu Phe Thr Arg His His Gly Thr Met Ser Asp Val
                1045                1050                1055    
Leu Arg Ala Glu Arg Tyr Leu Leu Thr Gln Glu Leu Leu Gln Gly Gly
            1060                1065                1070        
Glu Val His Arg Gly Val Leu Asp Gln Leu Tyr Thr Ser Gln Ala Glu
        1075                1080                1085            
Ala Thr Leu Pro Gly Pro Thr Glu Ala Pro Asn Ala Pro Ser Thr Val
    1090                1095                1100                
Ser Ser Gly Leu Gly Ala Glu Glu Pro Leu Ser Ser Met Thr Asp Asp
1105                1110                1115                1120
Met Gly Ser Pro Leu Ser Thr Gly Tyr His Thr Arg Ser Gly Ser Glu
                1125                1130                1135    
Glu Ala Val Thr Asp Pro Gly Glu Arg Glu Ala Gly Ala Ser Leu Tyr
            1140                1145                1150        
Gln Gly Leu Met Arg Thr Ala Ser Glu Leu Leu Leu Asp Arg Arg Leu
        1155                1160                1165            
Arg Ile Pro Glu Leu Glu Glu Ala Glu Leu Phe Ala Glu Gly Gln Gly
    1170                1175                1180                
Arg Ala Leu Arg Leu Leu Arg Ala Val Tyr Gln Cys Val Ala Ala His
1185                1190                1195                1200
Ser Glu Leu Leu Cys Tyr Phe Ile Ile Ile Leu Asn His Met Val Thr
                1205                1210                1215    
Ala Ser Ala Gly Ser Leu Val Leu Pro Val Leu Val Phe Leu Trp Ala
            1220                1225                1230        
Met Leu Ser Ile Pro Arg Pro Ser Lys Arg Phe Trp Met Thr Ala Ile
        1235                1240                1245            
Val Phe Thr Glu Ile Ala Val Val Val Lys Tyr Leu Phe Gln Phe Gly
    1250                1255                1260                
Phe Phe Pro Trp Asn Ser His Val Val Leu Arg Arg Tyr Glu Asn Lys
1265                1270                1275                1280
Pro Tyr Phe Pro Pro Arg Ile Leu Gly Leu Glu Lys Thr Asp Gly Tyr
                1285                1290                1295    
Ile Lys Tyr Asp Leu Val Gln Leu Met Ala Leu Phe Phe His Arg Ser
            1300                1305                1310        
Gln Leu Leu Cys Tyr Gly Leu Trp Asp His Glu Glu Asp Ser Pro Ser
        1315                1320                1325            
Lys Glu His Asp Lys Ser Gly Glu Glu Glu Gln Gly Ala Glu Glu Gly
    1330                1335                1340                
Pro Gly Val Pro Ala Ala Thr Thr Glu Asp His Ile Gln Val Glu Ala
1345                1350                1355                1360
Arg Val Gly Pro Thr Asp Gly Thr Pro Glu Pro Gln Val Glu Leu Arg
                1365                1370                1375    
Pro Arg Asp Thr Arg Arg Ile Ser Leu Arg Phe Arg Arg Arg Lys Lys
            1380                1385                1390        
Glu Gly Pro Ala Arg Lys Gly Ala Ala Ala Ile Glu Ala Glu Asp Arg
        1395                1400                1405            
Glu Glu Glu Glu Gly Glu Glu Glu Lys Glu Ala Pro Thr Gly Arg Glu
    1410                1415                1420                
Lys Arg Pro Ser Arg Ser Gly Gly Arg Val Arg Ala Ala Gly Arg Arg
1425                1430                1435                1440
Leu Gln Gly Phe Cys Leu Ser Leu Ala Gln Gly Thr Tyr Arg Pro Leu
                1445                1450                1455    
Arg Arg Phe Phe His Asp Ile Leu His Thr Lys Tyr Arg Ala Ala Thr
            1460                1465                1470        
Asp Val Tyr Ala Leu Met Phe Leu Ala Asp Val Val Asp Phe Ile Ile
        1475                1480                1485            
Ile Ile Phe Gly Phe Trp Ala Phe Gly Lys His Ser Ala Ala Thr Asp
    1490                1495                1500                
Ile Thr Ser Ser Leu Ser Asp Asp Gln Val Pro Glu Ala Phe Leu Val
1505                1510                1515                1520
Met Leu Leu Ile Gln Phe Ser Thr Met Val Val Asp Arg Ala Leu Tyr
                1525                1530                1535    
Leu Arg Lys Thr Val Leu Gly Lys Leu Ala Phe Gln Val Ala Leu Val
            1540                1545                1550        
Leu Ala Ile His Leu Trp Met Phe Phe Ile Leu Pro Ala Val Thr Glu
        1555                1560                1565            
Arg Met Phe Asn Gln Asn Val Val Ala Gln Leu Trp Tyr Phe Val Lys
    1570                1575                1580                
Cys Ile Tyr Phe Ala Leu Ser Ala Tyr Gln Ile Arg Cys Gly Tyr Pro
1585                1590                1595                1600
Thr Arg Ile Leu Gly Asn Phe Leu Thr Lys Lys Tyr Asn His Leu Asn
                1605                1610                1615    
Leu Phe Leu Phe Gln Gly Phe Arg Leu Val Pro Phe Leu Val Glu Leu
            1620                1625                1630        
Arg Ala Val Met Asp Trp Val Trp Thr Asp Thr Thr Leu Ser Leu Ser
        1635                1640                1645            
Ser Trp Met Cys Val Glu Asp Ile Tyr Ala Asn Ile Phe Ile Ile Lys
    1650                1655                1660                
Cys Ser Arg Glu Thr Glu Lys Lys Tyr Pro Gln Pro Lys Gly Gln Lys
1665                1670                1675                1680
Lys Lys Lys Ile Val Lys Tyr Gly Met Gly Gly Leu Ile Ile Leu Phe
                1685                1690                1695    
Leu Ile Ala Ile Ile Trp Phe Pro Leu Leu Phe Met Ser Leu Val Arg
            1700                1705                1710        
Ser Val Val Gly Val Val Asn Gln Pro Ile Asp Val Thr Val Thr Leu
        1715                1720                1725            
Lys Leu Gly Gly Tyr Glu Pro Leu Phe Thr Met Ser Ala Gln Gln Pro
    1730                1735                1740                
Ser Ile Ile Pro Phe Thr Ala Gln Ala Tyr Glu Glu Leu Ser Arg Gln
1745                1750                1755                1760
Phe Asp Pro Gln Pro Leu Ala Met Gln Phe Ile Ser Gln Tyr Ser Pro
                1765                1770                1775    
Glu Asp Ile Val Thr Ala Gln Ile Glu Gly Ser Ser Gly Ala Leu Trp
            1780                1785                1790        
Arg Ile Ser Pro Pro Ser Arg Ala Gln Met Lys Arg Glu Leu Tyr Asn
        1795                1800                1805            
Gly Thr Ala Asp Ile Thr Leu Arg Phe Thr Trp Asn Phe Gln Arg Asp
    1810                1815                1820                
Leu Ala Lys Gly Gly Thr Val Glu Tyr Ala Asn Glu Lys His Met Leu
1825                1830                1835                1840
Ala Leu Ala Pro Asn Ser Thr Ala Arg Arg Gln Leu Ala Ser Leu Leu
                1845                1850                1855    
Glu Gly Thr Ser Asp Gln Ser Val Val Ile Pro Asn Leu Phe Pro Lys
            1860                1865                1870        
Tyr Ile Arg Ala Pro Asn Gly Pro Glu Ala Asn Pro Val Lys Gln Leu
        1875                1880                1885            
Gln Pro Asn Glu Glu Ala Asp Tyr Leu Gly Val Arg Ile Gln Leu Arg
    1890                1895                1900                
Arg Glu Gln Gly Ala Gly Ala Thr Gly Phe Leu Glu Trp Trp Val Ile
1905                1910                1915                1920
Glu Leu Gln Glu Cys Arg Thr Asp Cys Asn Leu Leu Pro Met Val Ile
                1925                1930                1935    
Phe Ser Asp Lys Val Ser Pro Pro Ser Leu Gly Phe Leu Ala Gly Tyr
            1940                1945                1950        
Gly Ile Met Gly Leu Tyr Val Ser Ile Val Leu Val Ile Gly Lys Phe
        1955                1960                1965            
Val Arg Gly Phe Phe Ser Glu Ile Ser His Ser Ile Met Phe Glu Glu
    1970                1975                1980                
Leu Pro Cys Val Asp Arg Ile Leu Lys Leu Cys Gln Asp Ile Phe Leu
1985                1990                1995                2000
Val Arg Glu Thr Arg Glu Leu Glu Leu Glu Glu Glu Leu Tyr Ala Lys
                2005                2010                2015    
Leu Ile Phe Leu Tyr Arg Ser Pro Glu Thr Met Ile Lys Trp Thr Arg
            2020                2025                2030        
Glu Lys Glu
        2035


<210> 9453
<211> 2436
<212> PRT
<213> Homo sapiens

<400> 9453
Met Gly Phe Leu His Gln Leu Gln Leu Leu Leu Trp Lys Asn Val Thr
 1               5                  10                  15      
Leu Lys Arg Arg Ser Pro Trp Val Leu Ala Phe Glu Ile Phe Ile Pro
            20                  25                  30          
Leu Val Leu Phe Phe Ile Leu Leu Gly Leu Arg Gln Lys Lys Pro Thr
        35                  40                  45              
Ile Ser Val Lys Glu Val Pro Phe Tyr Thr Ala Ala Pro Leu Thr Ser
    50                  55                  60                  
Ala Gly Ile Leu Pro Val Met Gln Ser Leu Cys Pro Asp Gly Gln Arg
65                  70                  75                  80  
Asp Glu Phe Gly Phe Leu Gln Tyr Ala Asn Ser Thr Val Thr Gln Leu
                85                  90                  95      
Leu Glu Arg Leu Asp Arg Val Val Glu Glu Gly Asn Leu Phe Asp Pro
            100                 105                 110         
Ala Arg Pro Ser Leu Gly Ser Glu Leu Glu Ala Leu Arg Gln His Leu
        115                 120                 125             
Glu Ala Leu Ser Ala Gly Pro Gly Thr Ser Gly Ser His Leu Asp Arg
    130                 135                 140                 
Ser Thr Val Ser Ser Phe Ser Leu Asp Ser Val Ala Arg Asn Pro Gln
145                 150                 155                 160 
Glu Leu Trp Arg Phe Leu Thr Gln Asn Leu Ser Leu Pro Asn Ser Thr
                165                 170                 175     
Ala Gln Ala Leu Leu Ala Ala Arg Val Asp Pro Pro Glu Val Tyr His
            180                 185                 190         
Leu Leu Phe Gly Pro Ser Ser Ala Leu Asp Ser Gln Ser Gly Leu His
        195                 200                 205             
Lys Gly Gln Glu Pro Trp Ser Arg Leu Gly Gly Asn Pro Leu Phe Arg
    210                 215                 220                 
Met Glu Glu Leu Leu Leu Ala Pro Ala Leu Leu Glu Gln Leu Thr Cys
225                 230                 235                 240 
Thr Pro Gly Ser Gly Glu Leu Gly Arg Ile Leu Thr Val Pro Glu Ser
                245                 250                 255     
Gln Lys Gly Ala Leu Gln Gly Tyr Arg Asp Ala Val Cys Ser Gly Gln
            260                 265                 270         
Ala Ala Ala Arg Ala Arg Arg Phe Ser Gly Leu Ser Ala Glu Leu Arg
        275                 280                 285             
Asn Gln Leu Asp Val Ala Lys Val Ser Gln Gln Leu Gly Leu Asp Ala
    290                 295                 300                 
Pro Asn Gly Ser Asp Ser Ser Pro Gln Ala Pro Pro Pro Arg Arg Leu
305                 310                 315                 320 
Gln Ala Leu Leu Gly Asp Leu Leu Asp Ala Gln Lys Val Leu Gln Asp
                325                 330                 335     
Val Asp Val Leu Ser Ala Leu Ala Leu Leu Leu Pro Gln Gly Ala Cys
            340                 345                 350         
Thr Gly Arg Thr Pro Gly Pro Pro Ala Ser Gly Ala Gly Gly Ala Ala
        355                 360                 365             
Asn Gly Thr Gly Ala Gly Ala Val Met Gly Pro Asn Ala Thr Ala Glu
    370                 375                 380                 
Glu Gly Ala Pro Ser Ala Ala Ala Leu Ala Thr Pro Asp Thr Leu Gln
385                 390                 395                 400 
Gly Gln Cys Ser Ala Phe Val Gln Leu Trp Ala Gly Leu Gln Pro Ile
                405                 410                 415     
Leu Cys Gly Asn Asn Arg Thr Ile Glu Pro Glu Ala Leu Arg Arg Gly
            420                 425                 430         
Asn Met Ser Ser Leu Gly Phe Thr Ser Lys Glu Gln Arg Asn Leu Gly
        435                 440                 445             
Leu Leu Val His Leu Met Thr Ser Asn Pro Lys Ile Leu Tyr Ala Pro
    450                 455                 460                 
Ala Gly Ser Glu Val Asp Arg Val Ile Leu Lys Ala Asn Glu Thr Phe
465                 470                 475                 480 
Ala Phe Val Gly Asn Val Thr His Tyr Ala Gln Val Trp Leu Asn Ile
                485                 490                 495     
Ser Ala Glu Ile Arg Ser Phe Leu Glu Gln Gly Arg Leu Gln Gln His
            500                 505                 510         
Leu Arg Trp Leu Gln Gln Tyr Val Ala Glu Leu Arg Leu His Pro Glu
        515                 520                 525             
Ala Leu Asn Leu Ser Leu Asp Glu Leu Pro Pro Ala Leu Arg Gln Asp
    530                 535                 540                 
Asn Phe Ser Leu Pro Ser Gly Met Ala Leu Leu Gln Gln Leu Asp Thr
545                 550                 555                 560 
Ile Asp Asn Ala Ala Cys Gly Trp Ile Gln Phe Met Ser Lys Val Ser
                565                 570                 575     
Val Asp Ile Phe Lys Gly Phe Pro Asp Glu Glu Ser Ile Val Asn Tyr
            580                 585                 590         
Thr Leu Asn Gln Ala Tyr Gln Asp Asn Val Thr Val Phe Ala Ser Val
        595                 600                 605             
Ile Phe Gln Thr Arg Lys Asp Gly Ser Leu Pro Pro His Val His Tyr
    610                 615                 620                 
Lys Ile Arg Gln Asn Ser Ser Phe Thr Glu Lys Thr Asn Glu Ile Arg
625                 630                 635                 640 
Arg Ala Tyr Trp Arg Pro Gly Pro Asn Thr Gly Gly Arg Phe Tyr Phe
                645                 650                 655     
Leu Tyr Gly Phe Val Trp Ile Gln Asp Met Met Glu Arg Ala Ile Ile
            660                 665                 670         
Asp Thr Phe Val Gly His Asp Val Val Glu Pro Gly Ser Tyr Val Gln
        675                 680                 685             
Met Phe Pro Tyr Pro Cys Tyr Thr Arg Asp Asp Phe Leu Phe Val Ile
    690                 695                 700                 
Glu His Met Met Pro Leu Cys Met Val Ile Ser Trp Val Tyr Ser Val
705                 710                 715                 720 
Ala Met Thr Ile Gln His Ile Val Ala Glu Lys Glu His Arg Leu Lys
                725                 730                 735     
Glu Val Met Lys Thr Met Gly Leu Asn Asn Ala Val His Trp Val Ala
            740                 745                 750         
Trp Phe Ile Thr Gly Phe Val Gln Leu Ser Ile Ser Val Thr Ala Leu
        755                 760                 765             
Thr Ala Ile Leu Lys Tyr Gly Gln Val Leu Met His Ser His Val Val
    770                 775                 780                 
Ile Ile Trp Leu Phe Leu Ala Val Tyr Ala Val Ala Thr Ile Met Phe
785                 790                 795                 800 
Cys Phe Leu Val Ser Val Leu Tyr Ser Lys Ala Lys Leu Ala Ser Ala
                805                 810                 815     
Cys Gly Gly Ile Ile Tyr Phe Leu Ser Tyr Val Pro Tyr Met Tyr Val
            820                 825                 830         
Ala Ile Arg Glu Glu Val Ala His Asp Lys Ile Thr Ala Phe Glu Lys
        835                 840                 845             
Cys Ile Ala Ser Leu Met Ser Thr Thr Ala Phe Gly Leu Gly Ser Lys
    850                 855                 860                 
Tyr Phe Ala Leu Tyr Glu Val Ala Gly Val Gly Ile Gln Trp His Thr
865                 870                 875                 880 
Phe Ser Gln Ser Pro Val Glu Gly Asp Asp Phe Asn Leu Leu Leu Ala
                885                 890                 895     
Val Thr Met Leu Met Val Asp Ala Val Val Tyr Gly Ile Leu Thr Trp
            900                 905                 910         
Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly Leu Pro Arg Pro Trp
        915                 920                 925             
Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly Ser Gly Arg Thr Glu
    930                 935                 940                 
Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr Pro Arg Leu Ser Val
945                 950                 955                 960 
Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser Arg Arg Phe Glu Glu
                965                 970                 975     
Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu Pro Leu Val Val Cys
            980                 985                 990         
Val Asp Lys Leu Thr Lys Val Tyr Lys Asp Asp Lys Lys Leu Ala Leu
        995                 1000                1005            
Asn Lys Leu Ser Leu Asn Leu Tyr Glu Asn Gln Val Val Ser Phe Leu
    1010                1015                1020                
Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser Ile Leu Thr Gly
1025                1030                1035                1040
Leu Phe Pro Pro Thr Ser Gly Ser Ala Thr Ile Tyr Gly His Asp Ile
                1045                1050                1055    
Arg Thr Glu Met Asp Glu Ile Arg Lys Asn Leu Gly Met Cys Pro Gln
            1060                1065                1070        
His Asn Val Leu Phe Asp Arg Leu Thr Val Glu Glu His Leu Trp Phe
        1075                1080                1085            
Tyr Ser Arg Leu Lys Ser Met Ala Gln Glu Glu Ile Arg Arg Glu Met
    1090                1095                1100                
Asp Lys Met Ile Glu Asp Leu Glu Leu Ser Asn Lys Arg His Ser Leu
1105                1110                1115                1120
Val Gln Thr Leu Ser Gly Gly Met Lys Arg Lys Leu Ser Val Ala Ile
                1125                1130                1135    
Ala Phe Val Gly Gly Ser Arg Ala Ile Ile Leu Asp Glu Pro Thr Ala
            1140                1145                1150        
Gly Val Asp Pro Tyr Ala Arg Arg Ala Ile Trp Asp Leu Ile Leu Lys
        1155                1160                1165            
Tyr Lys Pro Gly Arg Thr Ile Leu Leu Ser Thr His His Met Asp Glu
    1170                1175                1180                
Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ser His Gly Lys Leu
1185                1190                1195                1200
Lys Cys Cys Gly Ser Pro Leu Phe Leu Lys Gly Thr Tyr Gly Asp Gly
                1205                1210                1215    
Tyr Arg Leu Thr Leu Val Lys Arg Pro Ala Glu Pro Gly Gly Pro Gln
            1220                1225                1230        
Glu Pro Gly Leu Ala Ser Ser Pro Pro Gly Arg Ala Pro Leu Ser Ser
        1235                1240                1245            
Cys Ser Glu Leu Gln Val Ser Gln Phe Ile Arg Lys His Val Ala Ser
    1250                1255                1260                
Cys Leu Leu Val Ser Asp Thr Ser Thr Glu Leu Ser Tyr Ile Leu Pro
1265                1270                1275                1280
Ser Glu Ala Ala Lys Lys Gly Ala Phe Glu Arg Leu Phe Gln His Leu
                1285                1290                1295    
Glu Arg Ser Leu Asp Ala Leu His Leu Ser Ser Phe Gly Leu Met Asp
            1300                1305                1310        
Thr Thr Leu Glu Glu Val Phe Leu Lys Val Ser Glu Glu Asp Gln Ser
        1315                1320                1325            
Leu Glu Asn Ser Glu Ala Asp Val Lys Glu Ser Arg Lys Asp Val Leu
    1330                1335                1340                
Pro Gly Ala Glu Gly Pro Ala Ser Gly Glu Gly His Ala Gly Asn Leu
1345                1350                1355                1360
Ala Arg Cys Ser Glu Leu Thr Gln Ser Gln Ala Ser Leu Gln Ser Ala
                1365                1370                1375    
Ser Ser Val Gly Ser Ala Arg Gly Asp Glu Gly Ala Gly Tyr Thr Asp
            1380                1385                1390        
Val Tyr Gly Asp Tyr Arg Pro Leu Phe Asp Asn Pro Gln Asp Pro Asp
        1395                1400                1405            
Asn Val Ser Leu Gln Glu Val Glu Ala Glu Ala Leu Ser Arg Val Gly
    1410                1415                1420                
Gln Gly Ser Arg Lys Leu Asp Gly Gly Trp Leu Lys Val Arg Gln Phe
1425                1430                1435                1440
His Gly Leu Leu Val Lys Arg Phe His Cys Ala Arg Arg Asn Ser Lys
                1445                1450                1455    
Ala Leu Phe Ser Gln Ile Leu Leu Pro Ala Phe Phe Val Cys Val Ala
            1460                1465                1470        
Met Thr Val Ala Leu Ser Val Pro Glu Ile Gly Asp Leu Pro Pro Leu
        1475                1480                1485            
Val Leu Ser Pro Ser Gln Tyr His Asn Tyr Thr Gln Pro Arg Gly Asn
    1490                1495                1500                
Phe Ile Pro Tyr Ala Asn Glu Glu Arg Arg Glu Tyr Arg Leu Arg Leu
1505                1510                1515                1520
Ser Pro Asp Ala Ser Pro Gln Gln Leu Val Ser Thr Phe Arg Leu Pro
                1525                1530                1535    
Ser Gly Val Gly Ala Thr Cys Val Leu Lys Ser Pro Ala Asn Gly Ser
            1540                1545                1550        
Leu Gly Pro Thr Leu Asn Leu Ser Ser Gly Glu Ser Arg Leu Leu Ala
        1555                1560                1565            
Ala Arg Phe Phe Asp Ser Met Cys Leu Glu Ser Phe Thr Gln Gly Leu
    1570                1575                1580                
Pro Leu Ser Asn Phe Val Pro Pro Pro Pro Ser Pro Ala Pro Ser Asp
1585                1590                1595                1600
Ser Pro Ala Ser Pro Asp Glu Asp Leu Gln Ala Trp Asn Val Ser Leu
                1605                1610                1615    
Pro Pro Thr Ala Gly Pro Glu Met Trp Thr Ser Ala Pro Ser Leu Pro
            1620                1625                1630        
Arg Leu Val Arg Glu Pro Val Arg Cys Thr Cys Ser Ala Gln Gly Thr
        1635                1640                1645            
Gly Phe Ser Cys Pro Ser Ser Val Gly Gly His Pro Pro Gln Met Arg
    1650                1655                1660                
Val Val Thr Gly Asp Ile Leu Thr Asp Ile Thr Gly His Asn Val Ser
1665                1670                1675                1680
Glu Tyr Leu Leu Phe Thr Ser Asp Arg Phe Arg Leu His Arg Tyr Gly
                1685                1690                1695    
Ala Ile Thr Phe Gly Asn Val Leu Lys Ser Ile Pro Ala Ser Phe Gly
            1700                1705                1710        
Thr Arg Ala Pro Pro Met Val Arg Lys Ile Ala Val Arg Arg Ala Ala
        1715                1720                1725            
Gln Val Phe Tyr Asn Asn Lys Gly Tyr His Ser Met Pro Thr Tyr Leu
    1730                1735                1740                
Asn Ser Leu Asn Asn Ala Ile Leu Arg Ala Asn Leu Pro Lys Ser Lys
1745                1750                1755                1760
Gly Asn Pro Ala Ala Tyr Gly Ile Thr Val Thr Asn His Pro Met Asn
                1765                1770                1775    
Lys Thr Ser Ala Ser Leu Ser Leu Asp Tyr Leu Leu Gln Gly Thr Asp
            1780                1785                1790        
Val Val Ile Ala Ile Phe Ile Ile Val Ala Met Ser Phe Val Pro Ala
        1795                1800                1805            
Ser Phe Val Val Phe Leu Val Ala Glu Lys Ser Thr Lys Ala Lys His
    1810                1815                1820                
Leu Gln Phe Val Ser Gly Cys Asn Pro Ile Ile Tyr Trp Leu Ala Asn
1825                1830                1835                1840
Tyr Val Trp Asp Met Leu Asn Tyr Leu Val Pro Ala Thr Cys Cys Val
                1845                1850                1855    
Ile Ile Leu Phe Val Phe Asp Leu Pro Ala Tyr Thr Ser Pro Thr Asn
            1860                1865                1870        
Phe Pro Ala Val Leu Ser Leu Phe Leu Leu Tyr Gly Trp Ser Ile Thr
        1875                1880                1885            
Pro Ile Met Tyr Pro Ala Ser Phe Trp Phe Glu Val Pro Ser Ser Ala
    1890                1895                1900                
Tyr Val Phe Leu Ile Val Ile Asn Leu Phe Ile Gly Ile Thr Ala Thr
1905                1910                1915                1920
Val Ala Thr Phe Leu Leu Gln Leu Phe Glu His Asp Lys Asp Leu Lys
                1925                1930                1935    
Val Val Asn Ser Tyr Leu Lys Ser Cys Phe Leu Ile Phe Pro Asn Tyr
            1940                1945                1950        
Asn Leu Gly His Gly Leu Met Glu Met Ala Tyr Asn Glu Tyr Ile Asn
        1955                1960                1965            
Glu Tyr Tyr Ala Lys Ile Gly Gln Phe Asp Lys Met Lys Ser Pro Phe
    1970                1975                1980                
Glu Trp Asp Ile Val Thr Arg Gly Leu Val Ala Met Ala Val Glu Gly
1985                1990                1995                2000
Val Val Gly Phe Leu Leu Thr Ile Met Cys Gln Tyr Asn Phe Leu Arg
                2005                2010                2015    
Arg Pro Gln Arg Met Pro Val Ser Thr Lys Pro Val Glu Asp Asp Val
            2020                2025                2030        
Asp Val Ala Ser Glu Arg Gln Arg Val Leu Arg Gly Asp Ala Asp Asn
        2035                2040                2045            
Asp Met Val Lys Ile Glu Asn Leu Thr Lys Val Tyr Lys Ser Arg Lys
    2050                2055                2060                
Ile Gly Arg Ile Leu Ala Val Asp Arg Leu Cys Leu Gly Val Arg Pro
2065                2070                2075                2080
Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Ser
                2085                2090                2095    
Thr Phe Lys Met Leu Thr Gly Asp Glu Ser Thr Thr Gly Gly Glu Ala
            2100                2105                2110        
Phe Val Asn Gly His Ser Val Leu Lys Glu Leu Leu Gln Val Gln Gln
        2115                2120                2125            
Ser Leu Gly Tyr Cys Pro Gln Cys Asp Ala Leu Phe Asp Glu Leu Thr
    2130                2135                2140                
Ala Arg Glu His Leu Gln Leu Tyr Thr Arg Leu Arg Gly Ile Ser Trp
2145                2150                2155                2160
Lys Asp Glu Ala Arg Val Val Lys Trp Ala Leu Glu Lys Leu Glu Leu
                2165                2170                2175    
Thr Lys Tyr Ala Asp Lys Pro Ala Gly Thr Tyr Ser Gly Gly Asn Lys
            2180                2185                2190        
Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Tyr Pro Ala Phe Ile
        2195                2200                2205            
Phe Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Lys Ala Arg Arg Phe
    2210                2215                2220                
Leu Trp Asn Leu Ile Leu Asp Leu Ile Lys Thr Gly Arg Ser Val Val
2225                2230                2235                2240
Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu
                2245                2250                2255    
Ala Ile Met Val Asn Gly Arg Leu Arg Cys Leu Gly Ser Ile Gln His
            2260                2265                2270        
Leu Lys Asn Arg Phe Gly Asp Gly Tyr Met Ile Thr Val Arg Thr Lys
        2275                2280                2285            
Ser Ser Gln Ser Val Lys Asp Val Val Arg Phe Phe Asn Arg Asn Phe
    2290                2295                2300                
Pro Glu Ala Met Leu Lys Glu Arg His His Thr Lys Val Gln Tyr Gln
2305                2310                2315                2320
Leu Lys Ser Glu His Ile Ser Leu Ala Gln Val Phe Ser Lys Met Glu
                2325                2330                2335    
Gln Val Ser Gly Val Leu Gly Ile Glu Asp Tyr Ser Val Ser Gln Thr
            2340                2345                2350        
Thr Leu Asp Asn Val Phe Val Asn Phe Ala Lys Lys Gln Ser Asp Asn
        2355                2360                2365            
Leu Glu Gln Gln Glu Thr Glu Pro Pro Ser Ala Leu Gln Ser Pro Leu
    2370                2375                2380                
Gly Cys Leu Leu Ser Leu Leu Arg Pro Arg Ser Ala Pro Thr Glu Leu
2385                2390                2395                2400
Arg Ala Leu Val Ala Asp Glu Pro Glu Asp Leu Asp Thr Glu Asp Glu
                2405                2410                2415    
Gly Leu Ile Ser Phe Glu Glu Glu Arg Ala Gln Leu Ser Phe Asn Thr
            2420                2425                2430        
Asp Thr Leu Cys
        2435    


<210> 9454
<211> 1176
<212> PRT
<213> Homo sapiens

<400> 9454
Thr Val Leu Cys Phe Pro Gln Phe Arg Phe Ala Asp Gly Leu Asp Ile
 1               5                  10                  15      
Thr Leu Met Ile Leu Gly Ile Leu Ala Ser Leu Val Asn Gly Ala Cys
            20                  25                  30          
Leu Pro Leu Met Pro Leu Val Leu Gly Glu Met Ser Asp Asn Leu Ile
        35                  40                  45              
Ser Gly Cys Leu Val Gln Thr Asn Thr Ser Glu Tyr Thr Ile Ile Phe
    50                  55                  60                  
Leu Leu Thr Leu Tyr Tyr Val Gly Ile Gly Val Ala Ala Leu Ile Phe
65                  70                  75                  80  
Gly Tyr Ile Gln Ile Ser Leu Trp Ile Ile Thr Ala Ala Arg Gln Thr
                85                  90                  95      
Lys Arg Ile Arg Lys Gln Phe Phe His Ser Val Leu Ala Gln Asp Ile
            100                 105                 110         
Gly Trp Phe Asp Ser Cys Asp Ile Gly Glu Leu Asn Thr Arg Met Thr
        115                 120                 125             
Asp Asp Ile Asp Lys Ile Ser Asp Gly Ile Gly Asp Lys Ile Ala Leu
    130                 135                 140                 
Leu Phe Gln Asn Met Ser Thr Phe Ser Ile Gly Leu Ala Val Gly Leu
145                 150                 155                 160 
Val Lys Gly Trp Lys Leu Thr Leu Val Thr Leu Ser Thr Ser Pro Leu
                165                 170                 175     
Ile Met Ala Ser Ala Ala Ala Cys Ser Arg Met Val Ile Ser Leu Thr
            180                 185                 190         
Ser Lys Glu Leu Ser Ala Tyr Ser Lys Ala Gly Ala Val Ala Glu Glu
        195                 200                 205             
Val Leu Ser Ser Ile Arg Thr Val Ile Ala Phe Arg Ala Gln Glu Lys
    210                 215                 220                 
Glu Leu Gln Arg Tyr Thr Gln Asn Leu Lys Asp Ala Lys Asp Phe Gly
225                 230                 235                 240 
Ile Lys Arg Thr Ile Ala Ser Lys Val Ser Leu Gly Ala Val Tyr Phe
                245                 250                 255     
Phe Met Asn Gly Thr Tyr Gly Leu Ala Phe Trp Tyr Gly Thr Ser Leu
            260                 265                 270         
Ile Leu Asn Gly Glu Pro Gly Tyr Thr Ile Gly Thr Val Leu Ala Val
        275                 280                 285             
Lys Arg Lys Leu Ser Trp Lys Lys Thr Ile Leu Ile Leu Phe Leu Lys
    290                 295                 300                 
Cys Arg Asp Cys Gln Phe Thr Pro Leu Lys Ile Tyr Asn Phe Leu Cys
305                 310                 315                 320 
Phe Ser Lys Lys Pro Ser Ile Asp Asn Phe Ser Thr Ala Gly Tyr Lys
                325                 330                 335     
Pro Glu Ser Ile Glu Gly Thr Val Glu Phe Lys Asn Val Ser Phe Asn
            340                 345                 350         
Tyr Pro Ser Arg Pro Ser Ile Lys Ile Leu Lys Gly Leu Asn Leu Arg
        355                 360                 365             
Ile Lys Ser Gly Glu Thr Val Ala Leu Val Gly Leu Asn Gly Ser Gly
    370                 375                 380                 
Lys Ser Thr Val Val Gln Leu Leu Gln Arg Leu Tyr Asp Pro Asp Asp
385                 390                 395                 400 
Gly Phe Ile Met Val Asp Glu Asn Asp Ile Arg Ala Leu Asn Val Arg
                405                 410                 415     
His Tyr Arg Asp His Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe
            420                 425                 430         
Gly Thr Thr Ile Ser Asn Asn Ile Lys Tyr Gly Arg Asp Asp Val Thr
        435                 440                 445             
Asp Glu Glu Met Glu Arg Ala Ala Arg Glu Ala Asn Ala Tyr Asp Phe
    450                 455                 460                 
Ile Met Glu Phe Pro Asn Lys Phe Asn Thr Leu Val Gly Glu Lys Gly
465                 470                 475                 480 
Ala Gln Met Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala
                485                 490                 495     
Leu Val Arg Asn Pro Lys Ile Leu Ile Leu Asp Glu Ala Thr Ser Ala
            500                 505                 510         
Leu Asp Ser Glu Ser Lys Ser Ala Val Gln Ala Ala Leu Glu Lys Ala
        515                 520                 525             
Ser Lys Gly Arg Thr Thr Ile Val Val Ala His Arg Leu Ser Thr Ile
    530                 535                 540                 
Arg Ser Ala Asp Leu Ile Val Thr Leu Lys Asp Gly Met Leu Ala Glu
545                 550                 555                 560 
Lys Gly Ala His Ala Glu Leu Met Ala Lys Arg Gly Leu Tyr Tyr Ser
                565                 570                 575     
Leu Val Met Ser Gln Val Met Leu Asp Ile Met Leu Cys Gln Gln Gly
            580                 585                 590         
Leu Thr Phe Gln Arg Ser Tyr His Thr Arg Lys Gln Lys Leu Gln Ile
        595                 600                 605             
Ile Ile Leu Asn Phe Lys Lys Gln Pro Ser Leu Pro Glu Val Ser Leu
    610                 615                 620                 
Leu Lys Ile Leu Lys Leu Asn Lys Pro Glu Trp Pro Phe Val Val Leu
625                 630                 635                 640 
Gly Thr Leu Ala Ser Val Leu Asn Gly Thr Val His Pro Val Phe Ser
                645                 650                 655     
Ile Ile Phe Ala Lys Ile Ile Thr Met Phe Gly Asn Asn Asp Lys Thr
            660                 665                 670         
Thr Leu Lys His Asp Ala Glu Ile Tyr Ser Met Ile Phe Val Ile Leu
        675                 680                 685             
Gly Val Ile Cys Phe Val Ser Lys Cys Phe Leu Ile Tyr Ser Arg Lys
    690                 695                 700                 
Ile Thr Ser Gln Ile Lys Lys Met Ile Phe Asp Asn His Met Leu Ile
705                 710                 715                 720 
Leu Leu Phe Asp Ile Ala Trp Phe Asp Glu Lys Glu Asn Ser Thr Gly
                725                 730                 735     
Gly Leu Thr Thr Ile Leu Ala Ile Asp Ile Ala Gln Ile Gln Gly Val
            740                 745                 750         
Cys Ser Arg Ile Gly Val Leu Thr Gln Asn Ala Thr Asn Met Gly Leu
        755                 760                 765             
Ser Val Ile Ile Ser Phe Ile Tyr Gly Trp Glu Met Thr Phe Leu Ile
    770                 775                 780                 
Leu Ser Ile Ala Pro Val Leu Ala Val Thr Gly Met Ile Glu Thr Ala
785                 790                 795                 800 
Ala Met Thr Gly Phe Ala Asn Lys Asp Lys Gln Glu Leu Lys His Ala
                805                 810                 815     
Gly Lys Ile Ala Thr Glu Ala Leu Glu Asn Ile Arg Thr Ile Val Ser
            820                 825                 830         
Leu Thr Arg Glu Lys Ala Phe Glu Gln Met Tyr Lys Arg Cys Phe Arg
        835                 840                 845             
Leu Asn Thr Gly Val Pro Ser Thr Ser Lys Asp Tyr Ile Pro Val Pro
    850                 855                 860                 
Ala Phe Phe Phe Thr Phe Arg Val Leu Leu Phe Tyr Lys Gly Ser Met
865                 870                 875                 880 
Asp Asp Ser Asn Ala Leu Ser Phe Asp Arg Val Phe Thr Ala Ile Ala
                885                 890                 895     
Tyr Gly Ala Met Ala Ile Gly Glu Thr Leu Val Leu Ala Pro Glu Tyr
            900                 905                 910         
Ser Lys Ala Lys Ser Gly Ala Ala His Leu Phe Ala Leu Leu Glu Lys
        915                 920                 925             
Lys Pro Asn Ile Asp Ser Arg Ser Gln Glu Gly Lys Lys Pro Asp Thr
    930                 935                 940                 
Cys Glu Gly Asn Leu Glu Phe Arg Glu Val Ser Phe Phe Tyr Pro Cys
945                 950                 955                 960 
Arg Pro Asp Val Phe Ile Leu Arg Gly Leu Ser Leu Ser Ile Glu Arg
                965                 970                 975     
Gly Lys Thr Val Ala Phe Val Gly Ser Ser Gly Cys Gly Lys Ser Thr
            980                 985                 990         
Ser Val Gln Leu Leu Gln Arg Leu Tyr Asp Pro Val Gln Gly Gln Val
        995                 1000                1005            
Leu Phe Asp Gly Val Asp Ala Lys Glu Leu Asn Val Gln Trp Leu Arg
    1010                1015                1020                
Ser Gln Ile Ala Ile Val Pro Gln Glu Pro Val Leu Phe Asn Cys Ser
1025                1030                1035                1040
Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn Ser Arg Val Val Pro Leu
                1045                1050                1055    
Asp Glu Ile Lys Glu Ala Ala Asn Ala Ala Asn Ile His Ser Phe Ile
            1060                1065                1070        
Glu Gly Leu Pro Glu Lys Tyr Asn Thr Gln Val Gly Leu Lys Gly Ala
        1075                1080                1085            
Gln Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu
    1090                1095                1100                
Leu Gln Lys Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala Leu
1105                1110                1115                1120
Asp Asn Asp Ser Glu Lys Val Val Gln His Ala Leu Asp Lys Ala Arg
                1125                1130                1135    
Thr Gly Arg Thr Cys Leu Val Val Thr His Arg Leu Ser Ala Ile Gln
            1140                1145                1150        
Asn Ala Asp Leu Ile Val Val Leu His Asn Gly Lys Ile Lys Glu Gln
        1155                1160                1165            
Gly Thr His Gln Glu Leu Leu Arg
    1170                1175    


<210> 9455
<211> 1165
<212> PRT
<213> Homo sapiens

<400> 9455
Phe Arg Phe Ala Asp Gly Leu Asp Ile Thr Leu Met Ile Leu Gly Ile
 1               5                  10                  15      
Leu Ala Ser Leu Val Asn Gly Ala Cys Leu Pro Leu Met Pro Leu Val
            20                  25                  30          
Leu Gly Glu Met Ser Asp Asn Leu Ile Ser Gly Cys Leu Val Gln Thr
        35                  40                  45              
Asn Thr Ser Glu Leu Thr Leu Tyr Tyr Val Gly Ile Gly Val Ala Ala
    50                  55                  60                  
Leu Ile Phe Gly Tyr Ile Gln Ile Ser Leu Trp Ile Ile Thr Ala Ala
65                  70                  75                  80  
Arg Gln Thr Lys Arg Ile Arg Lys Gln Phe Phe His Ser Val Leu Ala
                85                  90                  95      
Gln Asp Ile Gly Trp Phe Asp Ser Cys Asp Ile Gly Glu Leu Asn Thr
            100                 105                 110         
Arg Met Thr Asp Asp Ile Asp Lys Ile Ser Asp Gly Ile Gly Asp Lys
        115                 120                 125             
Ile Ala Leu Leu Phe Gln Asn Met Ser Thr Phe Ser Ile Gly Leu Ala
    130                 135                 140                 
Val Gly Leu Val Lys Gly Trp Lys Leu Thr Leu Val Thr Leu Ser Thr
145                 150                 155                 160 
Ser Pro Leu Ile Met Ala Ser Ala Ala Ala Cys Ser Arg Met Val Ile
                165                 170                 175     
Ser Leu Thr Ser Lys Glu Leu Ser Ala Tyr Ser Lys Ala Gly Ala Val
            180                 185                 190         
Ala Glu Glu Val Leu Ser Ser Ile Arg Thr Val Ile Ala Phe Arg Ala
        195                 200                 205             
Gln Glu Lys Glu Leu Gln Arg Tyr Thr Gln Asn Leu Lys Asp Ala Lys
    210                 215                 220                 
Asp Phe Gly Ile Lys Arg Thr Ile Ala Ser Lys Val Ser Leu Gly Ala
225                 230                 235                 240 
Val Tyr Phe Phe Met Asn Gly Thr Tyr Gly Leu Ala Phe Trp Tyr Gly
                245                 250                 255     
Thr Ser Leu Ile Leu Asn Gly Glu Pro Gly Tyr Thr Ile Gly Thr Val
            260                 265                 270         
Leu Ala Val Lys Arg Lys Leu Ser Trp Lys Lys Thr Ile Leu Ile Leu
        275                 280                 285             
Phe Leu Lys Cys Arg Asp Cys Gln Phe Thr Pro Leu Lys Ile Tyr Asn
    290                 295                 300                 
Phe Leu Cys Phe Ser Lys Lys Pro Ser Ile Asp Asn Phe Ser Thr Ala
305                 310                 315                 320 
Gly Tyr Lys Pro Glu Ser Ile Glu Gly Thr Val Glu Phe Lys Asn Val
                325                 330                 335     
Ser Phe Asn Tyr Pro Ser Arg Pro Ser Ile Lys Ile Leu Lys Gly Leu
            340                 345                 350         
Asn Leu Arg Ile Lys Ser Gly Glu Thr Val Ala Leu Val Gly Leu Asn
        355                 360                 365             
Gly Ser Gly Lys Ser Thr Val Val Gln Leu Leu Gln Arg Leu Tyr Asp
    370                 375                 380                 
Pro Asp Asp Gly Phe Ile Met Val Asp Glu Asn Asp Ile Arg Ala Leu
385                 390                 395                 400 
Asn Val Arg His Tyr Arg Asp His Ile Gly Val Val Ser Gln Glu Pro
                405                 410                 415     
Val Leu Phe Gly Thr Thr Ile Ser Asn Asn Ile Lys Tyr Gly Arg Asp
            420                 425                 430         
Asp Val Thr Asp Glu Glu Met Glu Arg Ala Ala Arg Glu Ala Asn Ala
        435                 440                 445             
Tyr Asp Phe Ile Met Glu Phe Pro Asn Lys Phe Asn Thr Leu Val Gly
    450                 455                 460                 
Glu Lys Gly Ala Gln Met Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile
465                 470                 475                 480 
Ala Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Ile Leu Asp Glu Ala
                485                 490                 495     
Thr Ser Ala Leu Asp Ser Glu Ser Lys Ser Ala Val Gln Ala Ala Leu
            500                 505                 510         
Glu Lys Ala Ser Lys Gly Arg Thr Thr Ile Val Val Ala His Arg Leu
        515                 520                 525             
Ser Thr Ile Arg Ser Ala Asp Leu Ile Val Thr Leu Lys Asp Gly Met
    530                 535                 540                 
Leu Ala Glu Lys Gly Ala His Ala Glu Leu Met Ala Lys Arg Gly Leu
545                 550                 555                 560 
Tyr Tyr Ser Leu Val Met Ser Gln Val Met Leu Met Asp Ile Met Leu
                565                 570                 575     
Cys Gln Gln Gly Leu Thr Phe Gln Arg Ser Tyr His Thr Arg Lys Gln
            580                 585                 590         
Lys Leu Gln Ile Ile Ile Leu Asn Phe Lys Lys Gln Pro Ser Leu Pro
        595                 600                 605             
Glu Val Ser Leu Leu Lys Ile Leu Lys Leu Asn Lys Pro Glu Trp Pro
    610                 615                 620                 
Phe Val Val Leu Gly Thr Leu Ala Ser Val Leu Asn Gly Thr Val His
625                 630                 635                 640 
Pro Val Phe Ser Ile Ile Phe Ala Lys Ile Ile Thr Val Arg Val Ser
                645                 650                 655     
Gln Pro Ser Ala Leu Leu Ala Ser His Asn Ala His Cys Cys Lys Cys
            660                 665                 670         
Phe Leu Ile Tyr Ser Arg Lys Ile Thr Ser Gln Ile Lys Lys Met Ile
        675                 680                 685             
Phe Asp Asn His Met Leu Ile Leu Leu Phe Ser Arg Ile Leu Trp Phe
    690                 695                 700                 
Asp Glu Lys Glu Asn Ser Thr Gly Gly Leu Thr Thr Ile Leu Ala Ile
705                 710                 715                 720 
Asp Ile Ala Gln Ile Gln Gly Ala Thr Gly Ser Arg Ile Gly Val Leu
                725                 730                 735     
Thr Gln Asn Ala Thr Asn Met Gly Leu Ser Val Ile Ile Ser Phe Ile
            740                 745                 750         
Tyr Gly Trp Glu Met Thr Phe Leu Ile Leu Ser Ile Ala Pro Val Leu
        755                 760                 765             
Ala Val Thr Gly Met Ile Glu Thr Ala Ala Met Thr Gly Phe Ala Asn
    770                 775                 780                 
Lys Asp Lys Gln Glu Leu Lys His Ala Gly Lys Ile Ala Thr Glu Ala
785                 790                 795                 800 
Leu Glu Asn Ile Arg Thr Ile Val Ser Leu Thr Arg Glu Lys Ala Phe
                805                 810                 815     
Glu Gln Met Tyr Glu Glu Met Leu Gln Thr Gln His Arg Asn Thr Ser
            820                 825                 830         
Lys Lys Ala Gln Ile Ile Gly Ser Cys Tyr Ala Phe Ser His Ala Phe
        835                 840                 845             
Ile Tyr Phe Ala Tyr Ala Ala Gly Phe Arg Phe Gly Ala Tyr Leu Ile
    850                 855                 860                 
Gln Ala Gly Arg Met Thr Pro Glu Gly Met Phe Ile Val Phe Thr Ala
865                 870                 875                 880 
Ile Ala Tyr Gly Ala Met Ala Ile Gly Glu Thr Leu Val Leu Ala Pro
                885                 890                 895     
Glu Tyr Ser Lys Ala Lys Ser Gly Ala Ala His Leu Phe Ala Leu Leu
            900                 905                 910         
Glu Lys Lys Pro Asn Ile Asp Ser Arg Ser Gln Glu Gly Lys Lys Pro
        915                 920                 925             
Asp Thr Cys Glu Gly Asn Leu Glu Phe Arg Glu Val Ser Phe Phe Tyr
    930                 935                 940                 
Pro Cys Arg Pro Asp Val Phe Ile Leu Arg Gly Leu Ser Leu Ser Ile
945                 950                 955                 960 
Glu Arg Gly Lys Thr Val Ala Phe Val Gly Ser Ser Gly Cys Gly Lys
                965                 970                 975     
Ser Thr Ser Val Gln Leu Leu Gln Arg Leu Tyr Asp Pro Val Gln Gly
            980                 985                 990         
Gln Val Leu Phe Asp Gly Val Asp Ala Lys Glu Leu Asn Val Gln Trp
        995                 1000                1005            
Leu Arg Ser Gln Ile Ala Ile Val Pro Gln Glu Pro Val Leu Phe Asn
    1010                1015                1020                
Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn Ser Arg Val Val
1025                1030                1035                1040
Pro Leu Asp Glu Ile Lys Glu Ala Ala Asn Ala Ala Asn Ile His Ser
                1045                1050                1055    
Phe Ile Glu Gly Leu Pro Glu Lys Tyr Asn Thr Gln Val Gly Leu Lys
            1060                1065                1070        
Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg
        1075                1080                1085            
Ala Leu Leu Gln Lys Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser
    1090                1095                1100                
Ala Leu Asp Asn Asp Ser Glu Lys Val Val Gln His Ala Leu Asp Lys
1105                1110                1115                1120
Ala Arg Thr Gly Arg Thr Cys Leu Val Val Thr His Arg Leu Ser Ala
                1125                1130                1135    
Ile Gln Asn Ala Asp Leu Ile Val Val Leu His Asn Gly Lys Ile Lys
            1140                1145                1150        
Glu Gln Gly Thr His Gln Glu Leu Leu Arg Asn Arg Asp
        1155                1160                1165


<210> 9456
<211> 1165
<212> PRT
<213> Homo sapiens

<400> 9456
Gly Ala Thr Val Leu Cys Phe Pro Gln Phe Arg Phe Ala Asp Gly Leu
 1               5                  10                  15      
Asp Ile Thr Leu Met Ile Leu Gly Ile Leu Ala Ser Leu Val Asn Gly
            20                  25                  30          
Ala Cys Leu Pro Leu Met Pro Leu Val Leu Gly Glu Met Ser Asp Asn
        35                  40                  45              
Leu Ile Ser Gly Cys Leu Val Gln Thr Asn Thr Ser Glu Tyr Thr Ile
    50                  55                  60                  
Ile Phe Leu Leu Thr Leu Tyr Tyr Val Gly Ile Gly Val Ala Ala Leu
65                  70                  75                  80  
Ile Phe Gly Tyr Ile Gln Ile Ser Leu Trp Ile Ile Thr Ala Ala Arg
                85                  90                  95      
Gln Thr Lys Arg Ile Arg Lys Gln Phe Phe His Ser Val Leu Ala Gln
            100                 105                 110         
Asp Ile Gly Trp Phe Asp Ser Cys Asp Ile Gly Glu Leu Asn Thr Arg
        115                 120                 125             
Met Thr Asp Asp Ile Asp Lys Ile Ser Asp Gly Ile Gly Asp Lys Ile
    130                 135                 140                 
Ala Leu Leu Phe Gln Asn Met Ser Thr Phe Ser Ile Gly Leu Ala Val
145                 150                 155                 160 
Gly Leu Val Lys Gly Trp Lys Leu Thr Leu Val Thr Leu Ser Thr Ser
                165                 170                 175     
Pro Leu Ile Met Ala Ser Ala Ala Ala Cys Ser Arg Met Val Ile Ser
            180                 185                 190         
Leu Thr Ser Lys Glu Leu Ser Ala Tyr Ser Lys Ala Gly Ala Val Ala
        195                 200                 205             
Glu Glu Val Leu Ser Ser Ile Arg Thr Val Ile Ala Phe Arg Ala Gln
    210                 215                 220                 
Glu Lys Glu Leu Gln Arg Tyr Thr Gln Asn Leu Lys Asp Ala Lys Asp
225                 230                 235                 240 
Phe Gly Ile Lys Arg Thr Ile Ala Ser Lys Val Ser Leu Gly Ala Val
                245                 250                 255     
Tyr Phe Phe Met Asn Gly Thr Tyr Gly Leu Ala Phe Trp Tyr Gly Thr
            260                 265                 270         
Ser Leu Ile Leu Asn Gly Glu Pro Gly Tyr Thr Ile Gly Thr Val Leu
        275                 280                 285             
Ala Val Lys Arg Lys Leu Ser Trp Lys Lys Thr Ile Leu Ile Leu Phe
    290                 295                 300                 
Leu Lys Cys Arg Asp Cys Gln Phe Thr Pro Leu Lys Ile Tyr Asn Ile
305                 310                 315                 320 
Ser Cys Phe Ser Lys Lys Pro Ser Ile Asp Asn Phe Ser Thr Ala Gly
                325                 330                 335     
Tyr Lys Pro Glu Ser Ile Glu Gly Thr Val Glu Phe Lys Asn Val Ser
            340                 345                 350         
Phe Asn Tyr Pro Ser Arg Pro Ser Ile Lys Ile Leu Lys Gly Leu Asn
        355                 360                 365             
Leu Arg Ile Lys Ser Gly Glu Thr Val Ala Leu Val Gly Leu Asn Gly
    370                 375                 380                 
Ser Gly Lys Ser Thr Val Val Gln Leu Leu Gln Arg Leu Tyr Asp Pro
385                 390                 395                 400 
Asp Asp Gly Phe Ile Met Val Asp Glu Asn Asp Ile Arg Ala Leu Asn
                405                 410                 415     
Val Arg His Tyr Arg Asp His Ile Gly Val Val Ser Gln Glu Pro Val
            420                 425                 430         
Leu Phe Gly Thr Thr Ile Ser Asn Asn Ile Lys Tyr Gly Arg Asp Asp
        435                 440                 445             
Val Thr Asp Glu Glu Met Glu Arg Ala Ala Arg Glu Ala Asn Ala Tyr
    450                 455                 460                 
Asp Phe Ile Met Glu Phe Pro Asn Lys Phe Asn Thr Leu Val Gly Glu
465                 470                 475                 480 
Lys Gly Ala Gln Met Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala
                485                 490                 495     
Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Ile Leu Asp Glu Ala Thr
            500                 505                 510         
Ser Ala Leu Asp Ser Glu Ser Lys Ser Ala Val Gln Ala Ala Leu Glu
        515                 520                 525             
Lys Ala Ser Lys Gly Arg Thr Thr Ile Val Val Ala His Arg Leu Ser
    530                 535                 540                 
Thr Ile Arg Ser Ala Asp Leu Ile Val Thr Leu Lys Asp Gly Met Leu
545                 550                 555                 560 
Ala Glu Lys Gly Ala His Ala Glu Leu Met Ala Lys Arg Gly Leu Tyr
                565                 570                 575     
Tyr Ser Leu Val Met Ser Gln Val Met Leu Cys Asp Ile Met Leu Cys
            580                 585                 590         
Gln Gln Gly Leu Thr Phe Gln Arg Ser Tyr His Thr Arg Lys Gln Lys
        595                 600                 605             
Leu Gln Ile Ile Ile Leu Asn Phe Lys Lys Gln Pro Ser Leu Pro Glu
    610                 615                 620                 
Val Ser Leu Leu Lys Ile Leu Lys Leu Asn Lys Pro Glu Trp Pro Phe
625                 630                 635                 640 
Val Val Leu Gly Thr Leu Ala Ser Val Leu Asn Gly Thr Val His Pro
                645                 650                 655     
Val Phe Ser Ile Ile Phe Ala Lys Ile Ile Thr Met Phe Gly Asn Asn
            660                 665                 670         
Asp Lys Thr Thr Leu Lys His Asp Ala Glu Ile Tyr Ser Met Ile Phe
        675                 680                 685             
Val Ile Leu Gly Val Ile Cys Phe Val Ser Tyr Phe Met Gln Asp Ile
    690                 695                 700                 
Ala Trp Phe Asp Glu Lys Glu Asn Ser Thr Gly Gly Leu Thr Thr Ile
705                 710                 715                 720 
Leu Ala Ile Asp Ile Ala Gln Ile Gln Gly Ala Thr Gly Ser Arg Ile
                725                 730                 735     
Gly Val Leu Thr Gln Asn Ala Thr Asn Met Gly Leu Ser Val Ile Ile
            740                 745                 750         
Ser Phe Ile Tyr Gly Trp Glu Met Thr Phe Leu Ile Leu Ser Ile Ala
        755                 760                 765             
Pro Val Leu Ala Val Thr Gly Met Ile Glu Thr Ala Ala Met Thr Gly
    770                 775                 780                 
Phe Ala Asn Lys Asp Lys Gln Glu Leu Lys His Ala Gly Lys Ile Ala
785                 790                 795                 800 
Thr Glu Ala Leu Glu Asn Ile Arg Thr Ile Val Ser Leu Thr Arg Glu
                805                 810                 815     
Lys Ala Phe Glu Gln Met Tyr Lys Arg Cys Phe Arg Leu Asn Thr Gly
            820                 825                 830         
Val Pro Ser Thr Ser Lys Asp Tyr Ile Pro Val Pro Ala Phe Phe Phe
        835                 840                 845             
Thr Phe Arg Val Leu Leu Phe Tyr Lys Gly Ser Met Asp Asp Ser Asn
    850                 855                 860                 
Ala Leu Ser Phe Asp Arg Val Phe Thr Ala Ile Ala Tyr Gly Ala Met
865                 870                 875                 880 
Ala Ile Gly Glu Thr Leu Val Leu Ala Pro Glu Tyr Ser Lys Ala Lys
                885                 890                 895     
Ser Gly Ala Ala His Leu Phe Ala Leu Leu Glu Lys Lys Pro Asn Ile
            900                 905                 910         
Asp Ser Arg Ser Gln Glu Gly Lys Lys Pro Asp Thr Cys Glu Gly Asn
        915                 920                 925             
Leu Glu Phe Arg Glu Val Ser Phe Phe Tyr Pro Cys Arg Pro Asp Val
    930                 935                 940                 
Phe Ile Leu Arg Gly Leu Ser Leu Ser Ile Glu Arg Gly Lys Thr Val
945                 950                 955                 960 
Ala Phe Val Gly Ser Ser Gly Cys Gly Lys Ser Thr Ser Val Gln Leu
                965                 970                 975     
Leu Gln Arg Leu Tyr Asp Pro Val Gln Gly Gln Val Leu Phe Asp Gly
            980                 985                 990         
Val Asp Ala Lys Glu Leu Asn Val Gln Trp Leu Arg Ser Gln Ile Ala
        995                 1000                1005            
Ile Val Pro Gln Glu Pro Val Leu Phe Asn Cys Ser Ile Ala Glu Asn
    1010                1015                1020                
Ile Ala Tyr Gly Asp Asn Ser Arg Val Val Pro Leu Asp Glu Ile Lys
1025                1030                1035                1040
Glu Ala Ala Asn Ala Ala Asn Ile His Ser Phe Ile Glu Gly Leu Pro
                1045                1050                1055    
Glu Lys Tyr Asn Thr Gln Val Gly Leu Lys Gly Ala Gln Leu Ser Gly
            1060                1065                1070        
Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Leu Gln Lys Pro
        1075                1080                1085            
Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala Leu Asp Asn Asp Ser
    1090                1095                1100                
Glu Lys Val Val Gln His Ala Leu Asp Lys Ala Arg Thr Gly Arg Thr
1105                1110                1115                1120
Cys Leu Val Val Thr His Arg Leu Ser Ala Ile Gln Asn Ala Asp Leu
                1125                1130                1135    
Ile Val Val Leu His Asn Gly Lys Ile Lys Glu Gln Gly Thr His Gln
            1140                1145                1150        
Glu Leu Leu Arg Asn Arg Asp Ile Tyr Phe Lys Leu Val
        1155                1160                1165


<210> 9457
<211> 779
<212> PRT
<213> Homo sapiens

<400> 9457
Met Thr Pro Glu Phe Asp Glu Glu Val Val Phe Glu Asn Ser Pro Leu
 1               5                  10                  15      
Tyr Gln Tyr Leu Gln Asp Leu Gly His Thr Asp Phe Glu Ile Cys Ser
            20                  25                  30          
Ser Leu Ser Pro Lys Thr Glu Lys Cys Thr Thr Glu Gly Gln Gln Lys
        35                  40                  45              
Pro Pro Thr Arg Val Leu Pro Lys Gln Gly Ile Leu Leu Lys Val Ala
    50                  55                  60                  
Glu Thr Ile Lys Ser Trp Ile Phe Phe Ser Gln Cys Asn Lys Lys Asp
65                  70                  75                  80  
Asp Leu Leu His Lys Leu Asp Ile Gly Phe Arg Leu Asp Ser Leu His
                85                  90                  95      
Thr Ile Leu Gln Gln Glu Val Leu Leu Gln Glu Asp Val Glu Leu Ile
            100                 105                 110         
Glu Leu Leu Asp Pro Ser Ile Leu Ser Ala Gly Gln Ser Gln Gln Gln
        115                 120                 125             
Glu Asn Gly His Leu Pro Thr Leu Cys Ser Leu Ala Thr Pro Asn Ile
    130                 135                 140                 
Trp Asp Leu Ser Met Leu Phe Ala Phe Ile Ser Leu Leu Val Met Leu
145                 150                 155                 160 
Pro Thr Trp Trp Ile Val Ser Ser Trp Leu Val Trp Gly Val Ile Leu
                165                 170                 175     
Phe Val Tyr Leu Val Ile Arg Ala Leu Arg Leu Trp Arg Thr Ala Lys
            180                 185                 190         
Leu Gln Val Thr Leu Lys Lys Tyr Ser Val His Leu Glu Asp Met Ala
        195                 200                 205             
Thr Asn Ser Arg Ala Phe Thr Asn Leu Val Arg Lys Ala Leu Arg Leu
    210                 215                 220                 
Ile Gln Glu Thr Glu Val Ile Ser Arg Gly Phe Thr Leu Val Ser Ala
225                 230                 235                 240 
Ala Cys Pro Phe Asn Lys Ala Gly Gln His Pro Ser Gln His Leu Ile
                245                 250                 255     
Gly Leu Arg Lys Ala Val Tyr Arg Thr Leu Arg Ala Asn Phe Gln Ala
            260                 265                 270         
Ala Arg Leu Ala Thr Leu Tyr Met Leu Lys Asn Tyr Pro Leu Asn Ser
        275                 280                 285             
Glu Ser Asp Asn Val Thr Asn Tyr Ile Cys Val Val Pro Phe Lys Glu
    290                 295                 300                 
Leu Gly Leu Gly Leu Ser Glu Glu Gln Ile Ser Glu Glu Glu Ala His
305                 310                 315                 320 
Asn Phe Thr Asp Gly Phe Ser Leu Pro Ala Leu Lys Val Leu Phe Gln
                325                 330                 335     
Leu Trp Val Ala Gln Ser Ser Glu Phe Phe Arg Arg Leu Ala Leu Leu
            340                 345                 350         
Leu Ser Thr Ala Asn Ser Pro Pro Gly Pro Leu Leu Thr Pro Ala Leu
        355                 360                 365             
Leu Pro His Arg Ile Leu Ser Asp Val Thr Gln Gly Leu Pro His Ala
    370                 375                 380                 
His Ser Ala Cys Leu Glu Glu Leu Lys Arg Ser Tyr Glu Phe Tyr Arg
385                 390                 395                 400 
Tyr Phe Glu Thr Gln His Gln Ser Val Pro Gln Cys Leu Ser Lys Thr
                405                 410                 415     
Gln Gln Lys Ser Arg Glu Leu Asn Asn Val His Thr Ala Val Arg Ser
            420                 425                 430         
Leu Gln Leu His Leu Lys Ala Leu Leu Asn Glu Val Ile Ile Leu Glu
        435                 440                 445             
Asp Glu Leu Glu Lys Leu Val Cys Thr Lys Glu Thr Gln Glu Leu Val
    450                 455                 460                 
Ser Glu Ala Tyr Pro Ile Leu Glu Gln Lys Leu Lys Leu Ile Gln Pro
465                 470                 475                 480 
His Val Gln Ala Ser Asn Asn Cys Trp Glu Glu Ala Ile Ser Gln Val
                485                 490                 495     
Asp Lys Leu Leu Arg Arg Asn Thr Asp Lys Lys Gly Lys Pro Glu Ile
            500                 505                 510         
Ala Cys Glu Asn Pro His Cys Thr Val Val Pro Leu Lys Gln Pro Thr
        515                 520                 525             
Leu His Ile Ala Asp Lys Asp Pro Ile Pro Glu Glu Gln Glu Leu Glu
    530                 535                 540                 
Ala Tyr Val Asp Asp Ile Asp Ile Asp Ser Asp Phe Arg Lys Asp Asp
545                 550                 555                 560 
Phe Tyr Tyr Leu Ser Gln Glu Asp Lys Glu Arg Gln Lys Arg Glu His
                565                 570                 575     
Glu Glu Ser Lys Arg Val Leu Gln Glu Leu Lys Ser Val Leu Gly Phe
            580                 585                 590         
Lys Ala Ser Glu Ala Glu Arg Gln Lys Trp Lys Gln Leu Leu Phe Ser
        595                 600                 605             
Asp His Ala Val Leu Lys Ser Leu Ser Pro Val Asp Pro Val Glu Pro
    610                 615                 620                 
Ile Ser Asn Ser Glu Pro Ser Met Asn Ser Asp Met Gly Lys Val Ser
625                 630                 635                 640 
Lys Asn Asp Thr Glu Glu Glu Ser Asn Lys Ser Ala Thr Thr Asp Asn
                645                 650                 655     
Glu Ile Ser Arg Thr Glu Tyr Leu Cys Glu Asn Ser Leu Glu Gly Lys
            660                 665                 670         
Asn Lys Asp Asn Ser Ser Asn Glu Val Phe Pro Gln Gly Ala Glu Glu
        675                 680                 685             
Arg Met Cys Tyr Gln Cys Glu Ser Glu Asp Glu Pro Gln Ala Asp Gly
    690                 695                 700                 
Ser Gly Leu Thr Thr Ala Pro Pro Thr Pro Arg Asp Ser Leu Gln Pro
705                 710                 715                 720 
Ser Ile Lys Gln Arg Leu Ala Arg Leu Gln Leu Ser Pro Asp Phe Thr
                725                 730                 735     
Phe Thr Ala Gly Leu Ala Ala Glu Val Ala Ala Arg Ser Leu Ser Phe
            740                 745                 750         
Thr Thr Met Gln Glu Gln Thr Phe Gly Asp Glu Glu Glu Glu Gln Ile
        755                 760                 765             
Ile Glu Glu Asn Lys Asn Glu Ile Glu Glu Lys
    770                 775                 


<210> 9458
<211> 684
<212> PRT
<213> Homo sapiens

<400> 9458
Met Thr Pro Glu Phe Asp Glu Glu Val Val Phe Glu Asn Ser Pro Leu
 1               5                  10                  15      
Tyr Gln Tyr Leu Gln Asp Leu Gly His Thr Asp Phe Glu Ile Cys Ser
            20                  25                  30          
Ser Leu Ser Pro Lys Thr Glu Lys Cys Thr Thr Glu Gly Gln Gln Lys
        35                  40                  45              
Pro Pro Thr Arg Val Leu Pro Lys Gln Gly Ile Leu Leu Lys Val Ala
    50                  55                  60                  
Glu Thr Ile Lys Ser Trp Ile Phe Phe Ser Gln Cys Asn Lys Lys Asp
65                  70                  75                  80  
Asp Leu Leu His Lys Leu Asp Ile Gly Phe Arg Leu Asp Ser Leu His
                85                  90                  95      
Thr Ile Leu Gln Gln Glu Val Leu Leu Gln Glu Asp Val Glu Leu Ile
            100                 105                 110         
Glu Leu Leu Asp Pro Ser Ile Leu Ser Ala Gly Gln Ser Gln Gln Gln
        115                 120                 125             
Glu Asn Gly His Leu Pro Thr Leu Cys Ser Leu Ala Thr Pro Asn Ile
    130                 135                 140                 
Trp Asp Leu Ser Met Leu Phe Ala Phe Ile Ser Leu Leu Val Met Leu
145                 150                 155                 160 
Pro Thr Trp Trp Ile Val Ser Ser Trp Leu Val Trp Gly Val Ile Leu
                165                 170                 175     
Phe Val Tyr Leu Val Ile Arg Ala Leu Arg Leu Trp Arg Thr Ala Lys
            180                 185                 190         
Leu Gln Val Thr Leu Lys Lys Tyr Ser Val His Leu Glu Asp Met Ala
        195                 200                 205             
Thr Asn Ser Arg Ala Phe Thr Asn Leu Val Arg Lys Ala Leu Arg Leu
    210                 215                 220                 
Ile Gln Glu Thr Glu Val Ile Ser Arg Gly Phe Thr Leu Val Ser Ala
225                 230                 235                 240 
Ala Cys Pro Phe Asn Lys Ala Gly Gln His Pro Ser Gln His Leu Ile
                245                 250                 255     
Gly Leu Arg Lys Ala Val Tyr Arg Thr Leu Arg Ala Asn Phe Gln Ala
            260                 265                 270         
Ala Arg Leu Ala Thr Leu Tyr Met Leu Lys Asn Tyr Pro Leu Asn Ser
        275                 280                 285             
Glu Ser Asp Asn Val Thr Asn Tyr Ile Cys Val Val Pro Phe Lys Glu
    290                 295                 300                 
Leu Gly Leu Gly Leu Ser Glu Glu Gln Ile Ser Glu Glu Glu Ala His
305                 310                 315                 320 
Asn Phe Thr Asp Gly Phe Ser Leu Pro Ala Leu Lys Val Leu Phe Gln
                325                 330                 335     
Leu Trp Val Ala Gln Ser Ser Glu Phe Phe Arg Arg Val Ile Ile Leu
            340                 345                 350         
Glu Asp Glu Leu Glu Lys Leu Val Cys Thr Lys Glu Thr Gln Glu Leu
        355                 360                 365             
Val Ser Glu Ala Tyr Pro Ile Leu Glu Gln Lys Leu Lys Leu Ile Gln
    370                 375                 380                 
Pro His Val Gln Ala Ser Asn Asn Cys Trp Glu Glu Ala Ile Ser Gln
385                 390                 395                 400 
Val Asp Lys Leu Leu Arg Arg Asn Thr Asp Lys Lys Gly Lys Pro Glu
                405                 410                 415     
Ile Ala Cys Glu Asn Pro His Cys Thr Val Val Pro Leu Lys Gln Pro
            420                 425                 430         
Thr Leu His Ile Ala Asp Lys Asp Pro Ile Pro Glu Glu Gln Glu Leu
        435                 440                 445             
Glu Ala Tyr Val Asp Asp Ile Asp Ile Asp Ser Asp Phe Arg Lys Asp
    450                 455                 460                 
Asp Phe Tyr Tyr Leu Ser Gln Glu Asp Lys Glu Arg Gln Lys Arg Glu
465                 470                 475                 480 
His Glu Glu Ser Lys Arg Val Leu Gln Glu Leu Lys Ser Val Leu Gly
                485                 490                 495     
Phe Lys Ala Ser Glu Ala Glu Arg Gln Lys Trp Lys Gln Leu Leu Phe
            500                 505                 510         
Ser Asp His Ala Val Leu Lys Ser Leu Ser Pro Val Asp Pro Val Glu
        515                 520                 525             
Pro Ile Ser Asn Ser Glu Pro Ser Met Asn Ser Asp Met Gly Lys Val
    530                 535                 540                 
Ser Lys Asn Asp Thr Glu Glu Glu Ser Asn Lys Ser Ala Thr Thr Asp
545                 550                 555                 560 
Asn Glu Ile Ser Arg Thr Glu Tyr Leu Cys Glu Asn Ser Leu Glu Gly
                565                 570                 575     
Lys Asn Lys Asp Asn Ser Ser Asn Glu Val Phe Pro Gln Gly Ala Glu
            580                 585                 590         
Glu Arg Met Cys Tyr Gln Cys Glu Ser Glu Asp Glu Pro Gln Ala Asp
        595                 600                 605             
Gly Ser Gly Leu Thr Thr Ala Pro Pro Thr Pro Arg Asp Ser Leu Gln
    610                 615                 620                 
Pro Ser Ile Lys Gln Arg Leu Ala Arg Leu Gln Leu Ser Pro Asp Phe
625                 630                 635                 640 
Thr Phe Thr Ala Gly Leu Ala Ala Glu Val Ala Ala Arg Ser Leu Ser
                645                 650                 655     
Phe Thr Thr Met Gln Glu Gln Thr Phe Gly Asp Glu Glu Glu Glu Gln
            660                 665                 670         
Ile Ile Glu Glu Asn Lys Asn Glu Ile Glu Glu Lys
        675                 680                 


<210> 9459
<211> 388
<212> PRT
<213> Homo sapiens

<400> 9459
Gly Thr Arg Gly Pro Pro Gly Ser Pro Pro Pro Pro Pro His Val Arg
 1               5                  10                  15      
Gly Met Pro Gly Cys Pro Cys Pro Gly Cys Gly Met Ala Gly Pro Arg
            20                  25                  30          
Leu Leu Phe Leu Thr Ala Leu Ala Leu Glu Leu Leu Gly Arg Ala Gly
        35                  40                  45              
Gly Ser Gln Pro Ala Leu Arg Ser Arg Gly Thr Ala Thr Ala Cys Arg
    50                  55                  60                  
Leu Asp Asn Lys Glu Ser Glu Ser Trp Gly Ala Leu Leu Ser Gly Glu
65                  70                  75                  80  
Arg Leu Asp Thr Trp Ile Cys Ser Leu Leu Gly Ser Leu Met Val Gly
                85                  90                  95      
Leu Ser Gly Val Phe Pro Leu Leu Val Ile Pro Leu Glu Met Gly Thr
            100                 105                 110         
Met Leu Arg Ser Glu Ala Gly Ala Trp Arg Leu Lys Gln Leu Leu Ser
        115                 120                 125             
Phe Ala Leu Gly Gly Leu Leu Gly Asn Val Phe Leu His Leu Leu Pro
    130                 135                 140                 
Glu Ala Trp Ala Tyr Thr Cys Ser Ala Ser Pro Gly Gly Glu Gly Gln
145                 150                 155                 160 
Ser Leu Gln Gln Gln Gln Gln Leu Gly Leu Trp Val Ile Ala Gly Ile
                165                 170                 175     
Leu Thr Phe Leu Ala Leu Glu Lys Met Phe Leu Asp Ser Lys Glu Glu
            180                 185                 190         
Gly Thr Ser Gln Ala Pro Asn Lys Asp Pro Thr Ala Ala Ala Ala Ala
        195                 200                 205             
Leu Asn Gly Gly His Cys Leu Ala Gln Pro Ala Ala Glu Pro Gly Leu
    210                 215                 220                 
Gly Ala Val Val Arg Ser Ile Lys Val Ser Gly Tyr Leu Asn Leu Leu
225                 230                 235                 240 
Ala Asn Thr Ile Asp Asn Phe Thr His Gly Leu Ala Val Ala Ala Ser
                245                 250                 255     
Phe Leu Val Ser Lys Lys Ile Gly Leu Leu Thr Thr Met Ala Ile Leu
            260                 265                 270         
Leu His Glu Ile Pro His Glu Val Gly Asp Phe Ala Ile Leu Leu Arg
        275                 280                 285             
Ala Gly Phe Asp Arg Trp Ser Ala Ala Lys Leu Gln Leu Ser Thr Ala
    290                 295                 300                 
Leu Gly Gly Leu Leu Gly Ala Gly Phe Ala Ile Cys Thr Gln Ser Pro
305                 310                 315                 320 
Lys Gly Val Val Gly Cys Ser Pro Ala Ala Glu Glu Thr Ala Ala Trp
                325                 330                 335     
Val Leu Pro Phe Thr Ser Gly Gly Phe Leu Tyr Ile Ala Leu Val Asn
            340                 345                 350         
Val Leu Pro Asp Leu Leu Glu Glu Glu Asp Pro Trp Arg Ser Leu Gln
        355                 360                 365             
Gln Leu Leu Leu Leu Cys Ala Gly Ile Val Val Met Val Leu Phe Ser
    370                 375                 380                 
Leu Phe Val Asp
385             


<210> 9460
<211> 225
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 211, 218, 219
<223> Xaa = Any Amino Acid

<400> 9460
Thr Gln Leu Gly Phe Cys Ser Val Tyr Ile Val Phe Leu Ala Glu Asn
 1               5                  10                  15      
Val Lys Gln Val His Glu Gly Phe Leu Glu Ser Lys Val Phe Ile Ser
            20                  25                  30          
Asn Ser Thr Asn Ser Ser Asn Pro Cys Glu Arg Arg Ser Val Asp Leu
        35                  40                  45              
Arg Ile Tyr Met Leu Cys Phe Leu Pro Phe Ile Ile Leu Leu Val Phe
    50                  55                  60                  
Ile Arg Glu Leu Lys Asn Leu Phe Val Leu Ser Phe Leu Ala Asn Val
65                  70                  75                  80  
Ser Met Ala Val Ser Leu Val Ile Ile Tyr Gln Tyr Val Val Arg Asn
                85                  90                  95      
Met Pro Asp Pro His Asn Leu Pro Ile Val Ala Gly Trp Lys Lys Tyr
            100                 105                 110         
Pro Leu Phe Phe Gly Thr Ala Val Phe Ala Phe Glu Gly Ile Gly Val
        115                 120                 125             
Val Leu Pro Leu Glu Asn Gln Met Lys Glu Ser Lys Arg Phe Pro Gln
    130                 135                 140                 
Ala Leu Asn Ile Gly Met Gly Ile Val Thr Thr Leu Tyr Val Thr Leu
145                 150                 155                 160 
Ala Thr Leu Gly Tyr Met Cys Phe His Asp Glu Ile Lys Gly Ser Ile
                165                 170                 175     
Thr Leu Asn Leu Pro Gln Asp Val Trp Leu Tyr Gln Ser Val Lys Ile
            180                 185                 190         
Leu Tyr Ser Phe Gly His Phe Cys Gly His Ile Ser Ile Pro Val Leu
        195                 200                 205             
Cys Ser Xaa Gln Arg Ser Ile Ile Pro Xaa Xaa His Ile Gln Ile Ser
    210                 215                 220                 
Tyr
225 


<210> 9461
<211> 369
<212> PRT
<213> Homo sapiens

<400> 9461
Met Glu Val Ser Pro Trp Ser Cys Leu Gln Lys Gln Ala Ala Trp Gly
 1               5                  10                  15      
Arg Ser Val Val Asp Phe Phe Leu Val Ile Thr Gln Leu Gly Phe Cys
            20                  25                  30          
Ser Val Tyr Ile Val Phe Leu Ala Glu Asn Val Lys Gln Val His Glu
        35                  40                  45              
Gly Phe Leu Glu Ser Lys Val Phe Ile Ser Asn Ser Thr Asn Ser Ser
    50                  55                  60                  
Asn Pro Cys Glu Arg Arg Ser Val Asp Leu Arg Ile Tyr Met Leu Cys
65                  70                  75                  80  
Phe Leu Pro Phe Ile Ile Leu Leu Val Phe Ile Arg Glu Leu Lys Asn
                85                  90                  95      
Leu Phe Val Leu Ser Phe Leu Ala Asn Val Ser Met Ala Val Ser Leu
            100                 105                 110         
Val Ile Ile Tyr Gln Tyr Val Val Arg Asn Met Pro Asp Pro His Asn
        115                 120                 125             
Leu Pro Ile Val Ala Gly Trp Lys Lys Tyr Pro Leu Phe Phe Gly Thr
    130                 135                 140                 
Ala Val Phe Ala Phe Glu Gly Ile Gly Val Val Leu Pro Leu Glu Asn
145                 150                 155                 160 
Gln Met Lys Glu Ser Lys Arg Phe Pro Gln Ala Leu Asn Ile Gly Met
                165                 170                 175     
Gly Ile Val Thr Thr Leu Tyr Val Thr Leu Ala Thr Leu Gly Tyr Met
            180                 185                 190         
Cys Phe Arg Asp Glu Ile Lys Gly Ser Ile Thr Leu Asn Leu Pro Gln
        195                 200                 205             
Asp Val Trp Leu Tyr Gln Ser Val Lys Ile Leu Tyr Ser Phe Gly Ile
    210                 215                 220                 
Phe Val Thr Tyr Ser Ile Gln Phe Tyr Val Pro Ala Glu Ile Ile Ile
225                 230                 235                 240 
Pro Gly Ile Thr Ser Lys Phe His Thr Lys Trp Lys Gln Ile Cys Glu
                245                 250                 255     
Phe Gly Ile Arg Ser Phe Leu Val Ser Ile Thr Cys Ala Gly Ala Ile
            260                 265                 270         
Leu Ile Pro Arg Leu Asp Ile Val Ile Ser Phe Val Gly Ala Val Ser
        275                 280                 285             
Ser Ser Thr Leu Ala Leu Ile Leu Pro Pro Leu Val Glu Ile Leu Thr
    290                 295                 300                 
Phe Ser Lys Glu His Tyr Asn Ile Trp Met Val Leu Lys Asn Ile Ser
305                 310                 315                 320 
Ile Ala Phe Thr Gly Val Val Gly Phe Leu Leu Gly Thr Tyr Ile Thr
                325                 330                 335     
Val Glu Glu Ile Ile Tyr Pro Thr Pro Lys Val Val Ala Gly Thr Pro
            340                 345                 350         
Gln Ser Pro Phe Leu Asn Leu Asn Ser Thr Cys Leu Thr Ser Gly Leu
        355                 360                 365             
Lys
    


<210> 9462
<211> 222
<212> PRT
<213> Homo sapiens

<400> 9462
Thr Gln Leu Gly Phe Cys Ser Val Tyr Ile Val Phe Leu Ala Glu Asn
 1               5                  10                  15      
Val Lys Gln Val His Glu Gly Phe Leu Glu Ser Lys Val Phe Ile Ser
            20                  25                  30          
Asn Ser Thr Asn Ser Ser Asn Pro Cys Glu Arg Arg Ser Val Asp Leu
        35                  40                  45              
Arg Ile Tyr Met Leu Cys Phe Leu Pro Phe Ile Ile Leu Leu Val Phe
    50                  55                  60                  
Ile Arg Glu Leu Lys Asn Leu Phe Val Leu Ser Phe Leu Ala Asn Val
65                  70                  75                  80  
Ser Met Ala Val Ser Leu Val Ile Ile Tyr Gln Tyr Val Val Arg Asn
                85                  90                  95      
Met Pro Asp Pro His Asn Leu Pro Ile Val Ala Gly Trp Lys Lys Tyr
            100                 105                 110         
Pro Leu Phe Phe Gly Thr Ala Val Phe Ala Phe Glu Gly Ile Gly Val
        115                 120                 125             
Val Leu Pro Leu Glu Asn Gln Met Lys Glu Ser Lys Arg Phe Pro Gln
    130                 135                 140                 
Ala Leu Asn Ile Gly Met Gly Ile Val Thr Thr Leu Tyr Val Thr Leu
145                 150                 155                 160 
Ala Thr Leu Gly Tyr Met Cys Phe His Asp Glu Ile Lys Gly Ser Ile
                165                 170                 175     
Thr Leu Asn Leu Pro Gln Asp Val Trp Leu Tyr Gln Ser Val Lys Ile
            180                 185                 190         
Leu Tyr Ser Phe His Phe Cys Asp Ile Phe Asn Ser Val Leu Cys Ser
        195                 200                 205             
Ser Arg Asp His Tyr Pro Trp Asp His Ile Gln Ile Ser Tyr
    210                 215                 220         


<210> 9463
<211> 741
<212> PRT
<213> Homo sapiens

<400> 9463
Met Ala Leu Phe Thr Pro Trp Lys Leu Ser Ser Gln Lys Leu Gly Phe
 1               5                  10                  15      
Phe Leu Val Thr Phe Gly Phe Ile Trp Gly Met Met Leu Leu His Phe
            20                  25                  30          
Thr Ile Gln Gln Arg Thr Gln Pro Glu Ser Ser Ser Met Leu Arg Glu
        35                  40                  45              
Gln Ile Leu Asp Leu Ser Lys Arg Tyr Ile Lys Ala Leu Ala Glu Glu
    50                  55                  60                  
Asn Arg Asn Val Val Asp Gly Pro Tyr Ala Gly Val Met Thr Ala Tyr
65                  70                  75                  80  
Asp Leu Lys Lys Thr Leu Ala Val Leu Leu Asp Asn Ile Leu Gln Arg
                85                  90                  95      
Ile Gly Lys Leu Glu Ser Lys Val Asp Asn Leu Val Val Asn Gly Thr
            100                 105                 110         
Gly Thr Asn Ser Thr Asn Ser Thr Thr Ala Val Pro Ser Leu Val Ala
        115                 120                 125             
Leu Glu Lys Ile Asn Val Ala Asp Ile Ile Asn Gly Ala Gln Glu Lys
    130                 135                 140                 
Cys Val Leu Pro Pro Met Asp Gly Tyr Pro His Cys Glu Gly Lys Ile
145                 150                 155                 160 
Lys Trp Met Lys Asp Met Trp Arg Ser Asp Pro Cys Tyr Ala Asp Tyr
                165                 170                 175     
Gly Val Asp Gly Ser Thr Cys Ser Phe Phe Ile Tyr Leu Ser Glu Val
            180                 185                 190         
Glu Asn Trp Cys Pro His Leu Pro Trp Arg Ala Lys Asn Pro Tyr Glu
        195                 200                 205             
Glu Ala Asp His Asn Ser Leu Ala Glu Ile Arg Thr Asp Phe Asn Ile
    210                 215                 220                 
Leu Tyr Ser Met Met Lys Lys His Glu Glu Phe Arg Trp Met Arg Leu
225                 230                 235                 240 
Arg Ile Arg Arg Met Ala Asp Ala Trp Ile Gln Ala Ile Lys Ser Leu
                245                 250                 255     
Ala Glu Lys Gln Asn Leu Glu Lys Arg Lys Arg Lys Lys Val Leu Val
            260                 265                 270         
His Leu Gly Leu Leu Thr Lys Glu Ser Gly Phe Lys Ile Ala Glu Thr
        275                 280                 285             
Ala Phe Ser Gly Gly Pro Leu Gly Glu Leu Val Gln Trp Ser Asp Leu
    290                 295                 300                 
Ile Thr Ser Leu Tyr Leu Leu Gly His Asp Ile Arg Ile Ser Ala Ser
305                 310                 315                 320 
Leu Ala Glu Leu Lys Glu Ile Met Lys Lys Val Val Gly Asn Arg Ser
                325                 330                 335     
Gly Cys Pro Thr Val Gly Asp Arg Ile Val Glu Leu Ile Tyr Ile Asp
            340                 345                 350         
Ile Val Gly Leu Ala Gln Phe Lys Lys Thr Leu Gly Pro Ser Trp Val
        355                 360                 365             
His Tyr Gln Cys Met Leu Arg Val Leu Asp Ser Phe Gly Thr Glu Pro
    370                 375                 380                 
Glu Phe Asn His Ala Asn Tyr Ala Gln Ser Lys Gly His Lys Thr Pro
385                 390                 395                 400 
Trp Gly Lys Trp Asn Leu Asn Pro Gln Gln Phe Tyr Thr Met Phe Pro
                405                 410                 415     
His Thr Pro Asp Asn Ser Phe Leu Gly Phe Val Val Glu Gln His Leu
            420                 425                 430         
Asn Ser Ser Asp Ile His His Ile Asn Glu Ile Lys Arg Gln Asn Gln
        435                 440                 445             
Ser Leu Val Tyr Gly Lys Val Asp Ser Phe Trp Lys Asn Lys Lys Ile
    450                 455                 460                 
Tyr Leu Asp Ile Ile His Thr Tyr Met Glu Val His Ala Thr Val Tyr
465                 470                 475                 480 
Gly Ser Ser Thr Lys Asn Ile Pro Ser Tyr Val Lys Asn His Gly Ile
                485                 490                 495     
Leu Ser Gly Arg Asp Leu Gln Phe Leu Leu Arg Glu Thr Lys Leu Phe
            500                 505                 510         
Val Gly Leu Gly Phe Pro Tyr Glu Gly Pro Ala Pro Leu Glu Ala Ile
        515                 520                 525             
Ala Asn Gly Cys Ala Phe Leu Asn Pro Lys Phe Asn Pro Pro Lys Ser
    530                 535                 540                 
Ser Lys Asn Thr Asp Phe Phe Ile Gly Lys Pro Thr Leu Arg Glu Leu
545                 550                 555                 560 
Thr Ser Gln His Pro Tyr Ala Glu Val Phe Ile Gly Arg Pro His Val
                565                 570                 575     
Trp Thr Val Asp Leu Asn Asn Gln Glu Glu Val Glu Asp Ala Val Lys
            580                 585                 590         
Ala Ile Leu Asn Gln Lys Ile Glu Pro Tyr Met Pro Tyr Glu Phe Thr
        595                 600                 605             
Cys Glu Gly Met Leu Gln Arg Ile Asn Ala Phe Ile Glu Lys Gln Asp
    610                 615                 620                 
Phe Cys His Gly Gln Val Met Trp Pro Pro Leu Ser Ala Leu Gln Val
625                 630                 635                 640 
Lys Leu Ala Glu Pro Gly Gln Ser Cys Lys Gln Val Cys Gln Glu Ser
                645                 650                 655     
Gln Leu Ile Cys Glu Pro Ser Phe Phe Gln His Leu Asn Lys Asp Lys
            660                 665                 670         
Asp Met Leu Lys Tyr Lys Val Thr Cys Gln Ser Ser Glu Leu Ala Lys
        675                 680                 685             
Asp Ile Leu Val Pro Ser Phe Asp Pro Lys Asn Lys His Cys Val Phe
    690                 695                 700                 
Gln Gly Asp Leu Leu Leu Phe Ser Cys Ala Gly Ala His Pro Arg His
705                 710                 715                 720 
Gln Arg Val Cys Pro Cys Arg Asp Phe Ile Lys Gly Gln Val Ala Leu
                725                 730                 735     
Cys Lys Asp Cys Leu
            740     


<210> 9464
<211> 408
<212> PRT
<213> Homo sapiens

<400> 9464
Met Ile Pro Pro Glu Gln Pro Gln Gln Gln Leu Gln Pro Pro Ser Pro
 1               5                  10                  15      
Ala Pro Pro Asn His Val Val Thr Thr Ile Glu Asn Leu Pro Ala Glu
            20                  25                  30          
Gly Ser Gly Gly Gly Gly Ser Leu Ser Ala Ser Ser Arg Ala Gly Val
        35                  40                  45              
Arg Gln Arg Ile Arg Lys Val Leu Asn Arg Glu Met Leu Ile Ser Val
    50                  55                  60                  
Ala Leu Gly Gln Val Leu Ser Leu Leu Ile Cys Gly Ile Gly Leu Thr
65                  70                  75                  80  
Ser Lys Tyr Leu Ser Glu Asp Phe His Ala Asn Thr Pro Val Phe Gln
                85                  90                  95      
Ser Phe Leu Asn Tyr Ile Leu Leu Phe Leu Val Tyr Thr Thr Thr Leu
            100                 105                 110         
Ala Val Arg Gln Gly Glu Glu Asn Leu Leu Ala Ile Leu Arg Arg Arg
        115                 120                 125             
Trp Trp Lys Tyr Met Ile Leu Gly Leu Ile Asp Leu Glu Ala Asn Tyr
    130                 135                 140                 
Leu Val Val Lys Ala Tyr Gln Tyr Thr Thr Leu Thr Ser Ile Gln Leu
145                 150                 155                 160 
Leu Asp Cys Phe Val Ile Pro Val Val Ile Leu Leu Ser Trp Phe Phe
                165                 170                 175     
Leu Leu Ile Arg Tyr Lys Ala Val His Phe Ile Gly Ile Val Val Cys
            180                 185                 190         
Ile Leu Gly Met Gly Cys Met Val Gly Ala Asp Val Leu Val Gly Arg
        195                 200                 205             
His Gln Gly Ala Gly Glu Asn Lys Leu Val Gly Asp Leu Leu Val Leu
    210                 215                 220                 
Gly Gly Ala Thr Leu Tyr Gly Ile Ser Asn Val Trp Glu Glu Tyr Ile
225                 230                 235                 240 
Ile Arg Thr Leu Ser Arg Val Glu Phe Leu Gly Met Ile Gly Leu Phe
                245                 250                 255     
Gly Ala Phe Phe Ser Gly Ile Gln Leu Ala Ile Met Glu His Lys Glu
            260                 265                 270         
Leu Leu Lys Val Pro Trp Asp Trp Gln Ile Gly Leu Leu Tyr Val Gly
        275                 280                 285             
Phe Ser Ala Cys Met Phe Gly Leu Tyr Ser Phe Met Pro Val Val Ile
    290                 295                 300                 
Lys Lys Thr Ser Ala Thr Ser Val Asn Leu Ser Leu Leu Thr Ala Asp
305                 310                 315                 320 
Leu Tyr Ser Leu Phe Cys Gly Leu Phe Leu Phe His Tyr Lys Phe Ser
                325                 330                 335     
Gly Leu Tyr Leu Leu Ser Phe Phe Thr Ile Leu Ile Gly Leu Val Leu
            340                 345                 350         
Tyr Ser Ser Thr Ser Thr Tyr Ile Ala Gln Asp Pro Arg Val Tyr Lys
        355                 360                 365             
Gln Phe Arg Asn Pro Ser Gly Pro Val Val Asp Leu Pro Thr Thr Ala
    370                 375                 380                 
Gln Val Glu Pro Ser Val Thr Tyr Thr Ser Leu Gly Gln Glu Thr Glu
385                 390                 395                 400 
Glu Glu Pro His Val Arg Val Ala
                405             


<210> 9465
<211> 806
<212> PRT
<213> Homo sapiens

<400> 9465
Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr Leu
 1               5                  10                  15      
Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met Phe
            20                  25                  30          
Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu Asp
        35                  40                  45              
Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu
    50                  55                  60                  
Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn Ala
65                  70                  75                  80  
Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu
                85                  90                  95      
Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu Ala
            100                 105                 110         
Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro
        115                 120                 125             
Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln Glu
    130                 135                 140                 
Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe
145                 150                 155                 160 
Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu Tyr
                165                 170                 175     
Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg Pro
            180                 185                 190         
His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg Lys
        195                 200                 205             
Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly Leu
    210                 215                 220                 
Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr
225                 230                 235                 240 
Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu Thr
                245                 250                 255     
Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe
            260                 265                 270         
Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu Ala
        275                 280                 285             
Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His Arg
    290                 295                 300                 
Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys
305                 310                 315                 320 
Leu Gly Arg Thr Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala
                325                 330                 335     
Val Ser Phe Thr Ile Phe Leu Gly Leu Leu Val Val Asn Ala Ser Asp
            340                 345                 350         
Arg Phe Glu Gly Val Lys Thr Leu Pro Asn Glu Thr Phe Thr Asp Tyr
        355                 360                 365             
Pro Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe Ser Trp Thr Glu
    370                 375                 380                 
Met Leu Ile Met Lys Trp Val Leu Gly Met Ile Trp Ser Glu Cys Lys
385                 390                 395                 400 
Glu Ile Trp Glu Glu Gly Pro Arg Glu Tyr Val Leu His Leu Trp Asn
                405                 410                 415     
Leu Leu Asp Phe Gly Met Leu Ser Ile Phe Val Ala Ser Phe Thr Ala
            420                 425                 430         
Arg Phe Met Ala Phe Leu Lys Ala Thr Glu Ala Gln Leu Tyr Val Asp
        435                 440                 445             
Gln His Val Gln Asp Asp Thr Leu His Asn Val Ser Leu Pro Pro Glu
    450                 455                 460                 
Val Ala Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Trp Pro Ser Asp Pro
465                 470                 475                 480 
Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe
                485                 490                 495     
Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu
            500                 505                 510         
Gln Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val
        515                 520                 525             
Ile Phe Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu
    530                 535                 540                 
Tyr Ser Tyr Tyr Arg Gly Ala Lys Tyr Asn Pro Ala Phe Thr Thr Val
545                 550                 555                 560 
Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu
                565                 570                 575     
Val Ile Ser Val Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile
            580                 585                 590         
Gly Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Val Val Leu
        595                 600                 605             
Leu Asn Met Leu Ile Ala Met Ile Asn Asn Ser Tyr Gln Glu Ile Glu
    610                 615                 620                 
Glu Asp Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu
625                 630                 635                 640 
Ser Tyr Phe Asp Glu Gly Arg Thr Leu Pro Ala Pro Phe Asn Leu Val
                645                 650                 655     
Pro Ser Pro Lys Ser Phe Tyr Tyr Leu Ile Met Arg Ile Lys Met Cys
            660                 665                 670         
Leu Ile Lys Leu Cys Lys Ser Lys Ala Lys Ser Cys Glu Asn Asp Leu
        675                 680                 685             
Glu Met Gly Met Leu Asn Ser Lys Phe Lys Lys Thr Arg Tyr Gln Ala
    690                 695                 700                 
Gly Met Arg Asn Ser Glu Asn Leu Thr Ala Asn Asn Thr Leu Ser Lys
705                 710                 715                 720 
Pro Thr Arg Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val
                725                 730                 735     
Leu Lys Ala Gln Val Asp Arg Glu Asn Asp Glu Val Asn Glu Gly Glu
            740                 745                 750         
Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu
        755                 760                 765             
Glu Glu Lys Ser Gln Ala Thr Gly Glu Leu Ala Asp Leu Ile Gln Gln
    770                 775                 780                 
Leu Ser Glu Lys Phe Gly Lys Asn Leu Asn Lys Asp His Leu Arg Val
785                 790                 795                 800 
Asn Lys Gly Lys Asp Ile
                805     


<210> 9466
<211> 862
<212> PRT
<213> Homo sapiens

<400> 9466
Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr
 1               5                  10                  15      
Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met
            20                  25                  30          
Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu
        35                  40                  45              
Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu
    50                  55                  60                  
Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn
65                  70                  75                  80  
Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu
                85                  90                  95      
Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu
            100                 105                 110         
Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His
        115                 120                 125             
Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln
    130                 135                 140                 
Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg
145                 150                 155                 160 
Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu
                165                 170                 175     
Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg
            180                 185                 190         
Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg
        195                 200                 205             
Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly
    210                 215                 220                 
Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu
225                 230                 235                 240 
Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu
                245                 250                 255     
Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp
            260                 265                 270         
Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu
        275                 280                 285             
Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His
    290                 295                 300                 
Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys
305                 310                 315                 320 
Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Met Trp
                325                 330                 335     
Tyr Glu Asn Leu Ser Gly Leu Arg Gln Gln Ser Ile Ala Val Lys Phe
            340                 345                 350         
Leu Ala Val Phe Gly Val Ser Ile Gly Leu Pro Phe Leu Ala Ile Ala
        355                 360                 365             
Tyr Trp Ile Ala Pro Cys Ser Lys Leu Gly Arg Thr Leu Arg Ser Pro
    370                 375                 380                 
Phe Met Lys Phe Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly
385                 390                 395                 400 
Leu Leu Val Val Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu
                405                 410                 415     
Pro Asn Glu Thr Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys
            420                 425                 430         
Thr Thr Gln Phe Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu
        435                 440                 445             
Gly Met Ile Trp Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg
    450                 455                 460                 
Glu Tyr Val Leu His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser
465                 470                 475                 480 
Ile Phe Val Ala Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala
                485                 490                 495     
Thr Glu Ala Gln Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu
            500                 505                 510         
His Asn Val Ser Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg
        515                 520                 525             
Asp Lys Trp Trp Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr
    530                 535                 540                 
Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro
545                 550                 555                 560 
Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val
                565                 570                 575     
Lys Asp Ile Phe Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala
            580                 585                 590         
Phe Met Ile Gly Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys
        595                 600                 605             
Tyr Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe
    610                 615                 620                 
Trp Ser Ile Phe Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr
625                 630                 635                 640 
Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr
                645                 650                 655     
Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile
            660                 665                 670         
Asn Asn Ser Tyr Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys
        675                 680                 685             
Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr
    690                 695                 700                 
Leu Pro Ala Pro Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr
705                 710                 715                 720 
Leu Ile Met Arg Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys
                725                 730                 735     
Ala Lys Ser Cys Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys
            740                 745                 750         
Phe Lys Lys Thr Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu
        755                 760                 765             
Thr Ala Asn Asn Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met
    770                 775                 780                 
Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu
785                 790                 795                 800 
Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile
                805                 810                 815     
Ser Ser Leu Arg Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly
            820                 825                 830         
Glu Leu Ala Asp Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn
        835                 840                 845             
Leu Asn Lys Asp His Leu Arg Val Asn Lys Gly Lys Asp Ile
    850                 855                 860         


<210> 9467
<211> 806
<212> PRT
<213> Homo sapiens

<400> 9467
Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr
 1               5                  10                  15      
Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met
            20                  25                  30          
Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu
        35                  40                  45              
Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu
    50                  55                  60                  
Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn
65                  70                  75                  80  
Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu
                85                  90                  95      
Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu
            100                 105                 110         
Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His
        115                 120                 125             
Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln
    130                 135                 140                 
Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg
145                 150                 155                 160 
Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu
                165                 170                 175     
Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg
            180                 185                 190         
Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg
        195                 200                 205             
Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly
    210                 215                 220                 
Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu
225                 230                 235                 240 
Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu
                245                 250                 255     
Thr Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp
            260                 265                 270         
Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Thr Glu Glu Val Glu
        275                 280                 285             
Ala Ile Leu Asn Gly Asp Val Asn Phe Gln Val Trp Ser Asp His His
    290                 295                 300                 
Arg Pro Ser Leu Ser Arg Ile Lys Leu Ala Ile Lys Tyr Glu Val Lys
305                 310                 315                 320 
Leu Gly Arg Thr Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala
                325                 330                 335     
Val Ser Phe Thr Ile Phe Leu Gly Leu Leu Val Val Asn Ala Ser Asp
            340                 345                 350         
Arg Phe Glu Gly Val Lys Thr Leu Pro Asn Glu Thr Phe Thr Asp Tyr
        355                 360                 365             
Pro Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe Ser Trp Thr Glu
    370                 375                 380                 
Met Leu Ile Met Lys Trp Val Leu Gly Met Ile Trp Ser Glu Cys Lys
385                 390                 395                 400 
Glu Ile Trp Glu Glu Gly Pro Arg Glu Tyr Val Leu His Leu Trp Asn
                405                 410                 415     
Leu Leu Asp Phe Gly Met Leu Ser Ile Phe Val Ala Ser Phe Thr Ala
            420                 425                 430         
Arg Phe Met Ala Phe Leu Lys Ala Thr Glu Ala Gln Leu Tyr Val Asp
        435                 440                 445             
Gln His Val Gln Asp Asp Thr Leu His Asn Val Ser Leu Pro Pro Glu
    450                 455                 460                 
Val Ala Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Trp Pro Ser Asp Pro
465                 470                 475                 480 
Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe
                485                 490                 495     
Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu
            500                 505                 510         
Gln Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val
        515                 520                 525             
Ile Phe Ile Met Val Phe Val Ala Phe Met Ile Gly Met Phe Asn Leu
    530                 535                 540                 
Tyr Ser Tyr Tyr Arg Gly Ala Lys Tyr Asn Pro Ala Phe Thr Thr Val
545                 550                 555                 560 
Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu
                565                 570                 575     
Val Ile Ser Val Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile
            580                 585                 590         
Gly Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr Met Val Val Val Leu
        595                 600                 605             
Leu Asn Met Leu Ile Ala Met Ile Asn Asn Ser Tyr Gln Glu Ile Glu
    610                 615                 620                 
Glu Asp Ala Asp Val Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu
625                 630                 635                 640 
Ser Tyr Phe Asp Glu Gly Arg Thr Leu Pro Ala Pro Phe Asn Leu Val
                645                 650                 655     
Pro Ser Pro Lys Ser Phe Tyr Tyr Leu Ile Met Arg Ile Lys Met Cys
            660                 665                 670         
Leu Ile Lys Leu Cys Lys Ser Lys Ala Lys Ser Cys Glu Asn Asp Leu
        675                 680                 685             
Glu Met Gly Met Leu Asn Ser Lys Phe Lys Lys Thr Arg Tyr Gln Ala
    690                 695                 700                 
Gly Met Arg Asn Ser Glu Asn Leu Thr Ala Asn Asn Thr Leu Ser Lys
705                 710                 715                 720 
Pro Thr Arg Tyr Gln Lys Ile Met Lys Arg Leu Ile Lys Arg Tyr Val
                725                 730                 735     
Leu Lys Ala Gln Val Asp Arg Glu Asn Asp Glu Val Asn Glu Gly Glu
            740                 745                 750         
Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu
        755                 760                 765             
Glu Glu Lys Ser Gln Ala Thr Gly Glu Leu Ala Asp Leu Ile Gln Gln
    770                 775                 780                 
Leu Ser Glu Lys Phe Gly Lys Asn Leu Asn Lys Asp His Leu Arg Val
785                 790                 795                 800 
Asn Lys Gly Lys Asp Ile
                805     


<210> 9468
<211> 746
<212> PRT
<213> Homo sapiens

<400> 9468
Met Leu Arg Asn Ser Thr Phe Lys Asn Met Gln Arg Arg His Thr Thr
 1               5                  10                  15      
Leu Arg Glu Lys Gly Arg Arg Gln Ala Ile Arg Gly Pro Ala Tyr Met
            20                  25                  30          
Phe Asn Glu Lys Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu
        35                  40                  45              
Asp Ser Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu
    50                  55                  60                  
Glu Ser Lys Thr Leu Asn Phe Asn Cys Val Asp Tyr Met Gly Gln Asn
65                  70                  75                  80  
Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu
                85                  90                  95      
Leu Leu Lys Lys Glu Asn Leu Ala Arg Val Gly Asp Ala Leu Leu Leu
            100                 105                 110         
Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His
        115                 120                 125             
Pro Ala Phe Ala Gln Gly Gln Arg Leu Thr Leu Ser Pro Leu Glu Gln
    130                 135                 140                 
Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg
145                 150                 155                 160 
Phe Ser His Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Glu
                165                 170                 175     
Tyr Glu Ile Val His Ile Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg
            180                 185                 190         
Pro His Asp Tyr Phe Cys Lys Cys Asn Glu Cys Thr Glu Lys Gln Arg
        195                 200                 205             
Lys Asp Ser Phe Ser His Ser Arg Ser Arg Met Asn Ala Tyr Lys Gly
    210                 215                 220                 
Leu Ala Ser Ala Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu
225                 230                 235                 240 
Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Arg Leu Ala Asn Ile Glu
                245                 250                 255     
Thr Glu Phe Lys Leu Gly Arg Thr Leu Arg Ser Pro Phe Met Lys Phe
            260                 265                 270         
Val Ala His Ala Val Ser Phe Thr Ile Phe Leu Gly Leu Leu Val Val
        275                 280                 285             
Asn Ala Ser Asp Arg Phe Glu Gly Val Lys Thr Leu Pro Asn Glu Thr
    290                 295                 300                 
Phe Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe
305                 310                 315                 320 
Ser Trp Thr Glu Met Leu Ile Met Lys Trp Val Leu Gly Met Ile Trp
                325                 330                 335     
Ser Glu Cys Lys Glu Ile Trp Glu Glu Gly Pro Arg Glu Tyr Val Leu
            340                 345                 350         
His Leu Trp Asn Leu Leu Asp Phe Gly Met Leu Ser Ile Phe Val Ala
        355                 360                 365             
Ser Phe Thr Ala Arg Phe Met Ala Phe Leu Lys Ala Thr Glu Ala Gln
    370                 375                 380                 
Leu Tyr Val Asp Gln His Val Gln Asp Asp Thr Leu His Asn Val Ser
385                 390                 395                 400 
Leu Pro Pro Glu Val Ala Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Trp
                405                 410                 415     
Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile Ala Val
            420                 425                 430         
Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser
        435                 440                 445             
Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe
    450                 455                 460                 
Lys Phe Met Val Ile Phe Ile Met Val Phe Val Ala Phe Met Ile Gly
465                 470                 475                 480 
Met Phe Asn Leu Tyr Ser Tyr Tyr Arg Gly Ala Lys Tyr Asn Pro Ala
                485                 490                 495     
Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe
            500                 505                 510         
Gly Leu Ser Glu Val Ile Ser Val Val Leu Lys Tyr Asp His Lys Phe
        515                 520                 525             
Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Val Tyr Asn Val Thr Met
    530                 535                 540                 
Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Asn Ser Tyr
545                 550                 555                 560 
Gln Glu Ile Glu Glu Asp Ala Asp Val Glu Trp Lys Phe Ala Arg Ala
                565                 570                 575     
Lys Leu Trp Leu Ser Tyr Phe Asp Glu Gly Arg Thr Leu Pro Ala Pro
            580                 585                 590         
Phe Asn Leu Val Pro Ser Pro Lys Ser Phe Tyr Tyr Leu Ile Met Arg
        595                 600                 605             
Ile Lys Met Cys Leu Ile Lys Leu Cys Lys Ser Lys Ala Lys Ser Cys
    610                 615                 620                 
Glu Asn Asp Leu Glu Met Gly Met Leu Asn Ser Lys Phe Lys Lys Thr
625                 630                 635                 640 
Arg Tyr Gln Ala Gly Met Arg Asn Ser Glu Asn Leu Thr Ala Asn Asn
                645                 650                 655     
Thr Leu Ser Lys Pro Thr Arg Tyr Gln Lys Ile Met Lys Arg Leu Ile
            660                 665                 670         
Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Arg Glu Asn Asp Glu Val
        675                 680                 685             
Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg
    690                 695                 700                 
Tyr Glu Leu Leu Glu Glu Lys Ser Gln Ala Thr Gly Glu Leu Ala Asp
705                 710                 715                 720 
Leu Ile Gln Gln Leu Ser Glu Lys Phe Gly Lys Asn Leu Asn Lys Asp
                725                 730                 735     
His Leu Arg Val Asn Lys Gly Lys Asp Ile
            740                 745     


<210> 9469
<211> 189
<212> PRT
<213> Homo sapiens

<400> 9469
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu
 1               5                  10                  15      
Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys
            20                  25                  30          
Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu
        35                  40                  45              
Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys
    50                  55                  60                  
Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu
65                  70                  75                  80  
Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys
                85                  90                  95      
Asn Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val
            100                 105                 110         
Thr Thr Val Asp Pro Lys Asp Ser Tyr Ser Lys Asp Ala Asn Asp Val
        115                 120                 125             
Ile Thr Met Asp Pro Lys Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr
    130                 135                 140                 
Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu
145                 150                 155                 160 
Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu
                165                 170                 175     
Leu Gly Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser
            180                 185                 


<210> 9470
<211> 811
<212> PRT
<213> Homo sapiens

<400> 9470
Thr Met Ile Pro Val Thr Glu Leu Arg Tyr Phe Ala Asp Thr Gln Pro
 1               5                  10                  15      
Ala Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Ile
            20                  25                  30          
Ser Ile Val Met Leu Met Ile Ala Val Phe Gly Gly Thr Leu Gln Val
        35                  40                  45              
Thr Gln Asp Lys Met Ile Cys Leu Pro Cys Lys Trp Val Thr Lys Asp
    50                  55                  60                  
Ser Cys Asn Asp Ser Phe Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro
65                  70                  75                  80  
Thr Tyr Pro Asn Ser Thr Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr
                85                  90                  95      
Gly Ile Lys Tyr Asp Leu Asp Arg His Gln Tyr Asn Tyr Val Asp Ala
            100                 105                 110         
Val Cys Tyr Glu Asn Arg Leu His Trp Phe Ala Lys Tyr Phe Pro Tyr
        115                 120                 125             
Leu Val Leu Leu His Thr Leu Ile Phe Leu Ala Cys Ser Asn Phe Trp
    130                 135                 140                 
Phe Lys Phe Pro Arg Thr Ser Ser Lys Leu Glu His Phe Val Ser Ile
145                 150                 155                 160 
Leu Leu Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu
                165                 170                 175     
Thr Val Val Glu Glu Ser Asp Pro Lys Pro Ala Phe Ser Lys Met Asn
            180                 185                 190         
Gly Ser Met Asp Lys Lys Ser Ser Thr Val Ser Glu Asp Val Glu Ala
        195                 200                 205             
Thr Val Pro Met Leu Gln Arg Thr Lys Ser Arg Ile Glu Gln Gly Ile
    210                 215                 220                 
Val Asp Arg Ser Glu Thr Gly Val Leu Asp Lys Lys Glu Gly Glu Gln
225                 230                 235                 240 
Ala Lys Ala Leu Phe Glu Lys Val Lys Lys Phe Arg Thr His Val Glu
                245                 250                 255     
Glu Gly Asp Ile Val Tyr Arg Leu Tyr Met Arg Gln Thr Ile Ile Lys
            260                 265                 270         
Val Ile Lys Phe Ile Leu Ile Ile Cys Tyr Thr Val Tyr Tyr Val His
        275                 280                 285             
Asn Ile Lys Phe Asp Val Asp Cys Thr Val Asp Ile Glu Ser Leu Thr
    290                 295                 300                 
Gly Tyr Arg Thr Tyr Arg Cys Ala His Pro Leu Ala Thr Leu Phe Lys
305                 310                 315                 320 
Ile Leu Ala Ser Phe Tyr Ile Ser Leu Val Ile Phe Tyr Gly Leu Ile
                325                 330                 335     
Cys Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys Lys Tyr
            340                 345                 350         
Ser Phe Glu Ser Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp
        355                 360                 365             
Val Lys Asn Asp Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp
    370                 375                 380                 
Pro Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu
385                 390                 395                 400 
Asn Lys Leu Arg Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys
                405                 410                 415     
Leu Arg Gln Arg Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His
            420                 425                 430         
Leu Phe Met Leu Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu
        435                 440                 445             
Leu Glu Val Leu Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro
    450                 455                 460                 
Ser Ile Ala Gln Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr
465                 470                 475                 480 
Ala Ala Lys Ile Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu
                485                 490                 495     
Arg Ala Leu His Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp
            500                 505                 510         
Ile Tyr Ser Leu Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu
        515                 520                 525             
Ser Ala Glu Asn Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu
    530                 535                 540                 
Lys Arg Leu Lys Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro
545                 550                 555                 560 
Gln Val Val Thr Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn
                565                 570                 575     
Asn Glu Gly Thr Lys Leu Ile Val Leu Asn Ser Leu Lys Lys Met Ala
            580                 585                 590         
Asn Leu Thr Glu Leu Glu Leu Ile Arg Cys Asp Leu Glu Arg Ile Pro
        595                 600                 605             
His Ser Ile Phe Ser Leu His Asn Leu Gln Glu Ile Asp Leu Lys Asp
    610                 615                 620                 
Asn Asn Leu Lys Thr Ile Glu Glu Ile Ile Ser Phe Gln His Leu His
625                 630                 635                 640 
Arg Leu Thr Cys Leu Lys Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro
                645                 650                 655     
Ile Gln Ile Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg
            660                 665                 670         
Asn Lys Ile Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu
        675                 680                 685             
Arg Tyr Leu Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp
    690                 695                 700                 
Ile Gly Leu Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg
705                 710                 715                 720 
Ile Glu Thr Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala
                725                 730                 735     
Leu His Leu Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly
            740                 745                 750         
Glu Leu Thr Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu
        755                 760                 765             
Cys Leu Pro Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly
    770                 775                 780                 
Leu Val Val Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys
785                 790                 795                 800 
Glu Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala
                805                 810     


<210> 9471
<211> 546
<212> PRT
<213> Homo sapiens

<400> 9471
Met Arg Gln Thr Ile Ile Lys Val Ile Lys Phe Ile Leu Ile Ile Cys
 1               5                  10                  15      
Tyr Thr Val Tyr Tyr Val His Asn Ile Lys Phe Asp Val Asp Cys Thr
            20                  25                  30          
Val Asp Ile Glu Ser Leu Thr Gly Tyr Arg Thr Tyr Arg Cys Ala His
        35                  40                  45              
Pro Leu Ala Thr Leu Phe Lys Ile Leu Ala Ser Phe Tyr Ile Ser Leu
    50                  55                  60                  
Val Ile Phe Tyr Gly Leu Ile Cys Met Tyr Thr Leu Trp Trp Met Leu
65                  70                  75                  80  
Arg Arg Ser Leu Lys Lys Tyr Ser Phe Glu Ser Ile Arg Glu Glu Ser
                85                  90                  95      
Ser Tyr Ser Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe Met Leu
            100                 105                 110         
His Leu Ile Asp Gln Tyr Asp Pro Leu Tyr Ser Lys Arg Phe Ala Val
        115                 120                 125             
Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Arg Gln Leu Asn Leu Asn
    130                 135                 140                 
Asn Glu Trp Thr Leu Asp Lys Leu Arg Gln Arg Leu Thr Lys Asn Ala
145                 150                 155                 160 
Gln Asp Lys Leu Glu Leu His Leu Phe Met Leu Ser Gly Ile Pro Asp
                165                 170                 175     
Thr Val Phe Asp Leu Val Glu Leu Glu Val Leu Lys Leu Glu Leu Ile
            180                 185                 190         
Pro Asp Val Thr Ile Pro Pro Ser Ile Ala Gln Leu Thr Gly Leu Lys
        195                 200                 205             
Glu Leu Trp Leu Tyr His Thr Ala Ala Lys Ile Glu Ala Pro Ala Leu
    210                 215                 220                 
Ala Phe Leu Arg Glu Asn Leu Arg Ala Leu His Ile Lys Phe Thr Asp
225                 230                 235                 240 
Ile Lys Glu Ile Pro Leu Trp Ile Tyr Ser Leu Lys Thr Leu Glu Glu
                245                 250                 255     
Leu His Leu Thr Gly Asn Leu Ser Ala Glu Asn Asn Arg Tyr Ile Val
            260                 265                 270         
Ile Asp Gly Leu Arg Glu Leu Lys Arg Leu Lys Val Leu Arg Leu Lys
        275                 280                 285             
Ser Asn Leu Ser Lys Leu Pro Gln Val Val Thr Asp Val Gly Val His
    290                 295                 300                 
Leu Gln Lys Leu Ser Ile Asn Asn Glu Gly Thr Lys Leu Ile Val Leu
305                 310                 315                 320 
Asn Ser Leu Lys Lys Met Ala Asn Leu Thr Glu Leu Glu Leu Ile Arg
                325                 330                 335     
Cys Asp Leu Glu Arg Ile Pro His Ser Ile Phe Ser Leu His Asn Leu
            340                 345                 350         
Gln Glu Ile Asp Leu Lys Asp Asn Asn Leu Lys Thr Ile Glu Glu Ile
        355                 360                 365             
Ile Ser Phe Gln His Leu His Arg Leu Thr Cys Leu Lys Leu Trp Tyr
    370                 375                 380                 
Asn His Ile Ala Tyr Ile Pro Ile Gln Ile Gly Asn Leu Thr Asn Leu
385                 390                 395                 400 
Glu Arg Leu Tyr Leu Asn Arg Asn Lys Ile Glu Lys Ile Pro Thr Gln
                405                 410                 415     
Leu Phe Tyr Cys Arg Lys Leu Arg Tyr Leu Asp Leu Ser His Asn Asn
            420                 425                 430         
Leu Thr Phe Leu Pro Ala Asp Ile Gly Leu Leu Gln Asn Leu Gln Asn
        435                 440                 445             
Leu Ala Ile Thr Ala Asn Arg Ile Glu Thr Leu Pro Pro Glu Leu Phe
    450                 455                 460                 
Gln Cys Arg Lys Leu Arg Ala Leu His Leu Gly Asn Asn Val Leu Gln
465                 470                 475                 480 
Ser Leu Pro Ser Arg Val Gly Glu Leu Thr Asn Leu Thr Gln Ile Glu
                485                 490                 495     
Leu Arg Gly Asn Arg Leu Glu Cys Leu Pro Val Glu Leu Gly Glu Cys
            500                 505                 510         
Pro Leu Leu Lys Arg Ser Gly Leu Val Val Glu Glu Asp Leu Phe Asn
        515                 520                 525             
Thr Leu Pro Pro Glu Val Lys Glu Arg Leu Trp Arg Ala Asp Lys Glu
    530                 535                 540                 
Gln Ala
545     


<210> 9472
<211> 246
<212> PRT
<213> Homo sapiens

<400> 9472
Met Ala Ala Ala Ala Ala Thr Lys Ile Leu Leu Cys Leu Pro Leu Leu
 1               5                  10                  15      
Leu Leu Leu Ser Gly Trp Ser Arg Ala Gly Arg Ala Asp Pro His Ser
            20                  25                  30          
Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg
        35                  40                  45              
Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr
    50                  55                  60                  
Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys
65                  70                  75                  80  
Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu
                85                  90                  95      
Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile Gln Leu Glu Asn
            100                 105                 110         
Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu
        115                 120                 125             
Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Phe Asp
    130                 135                 140                 
Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr
145                 150                 155                 160 
Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys
                165                 170                 175     
Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly Asp Cys Ile Gly
            180                 185                 190         
Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser
        195                 200                 205             
Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala
    210                 215                 220                 
Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys
225                 230                 235                 240 
Phe Ile Leu Pro Gly Ile
                245     


<210> 9473
<211> 246
<212> PRT
<213> Homo sapiens

<400> 9473
Met Ala Ala Ala Ala Ile Pro Ala Leu Leu Leu Cys Leu Pro Leu Leu
 1               5                  10                  15      
Phe Leu Leu Phe Gly Trp Ser Arg Ala Arg Arg Asp Asp Pro His Ser
            20                  25                  30          
Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg
        35                  40                  45              
Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr
    50                  55                  60                  
Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys
65                  70                  75                  80  
Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu
                85                  90                  95      
Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn
            100                 105                 110         
Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu
        115                 120                 125             
Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Ile Asp
    130                 135                 140                 
Gly Gln Thr Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr
145                 150                 155                 160 
Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys
                165                 170                 175     
Asp Val Ala Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Ile Gly
            180                 185                 190         
Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser
        195                 200                 205             
Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala
    210                 215                 220                 
Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys
225                 230                 235                 240 
Phe Ile Leu Pro Gly Ile
                245     


<210> 9474
<211> 752
<212> PRT
<213> Homo sapiens

<400> 9474
Val Val Ala Ala Gly Thr Thr Asp Val Cys His Gln Ala Gln Leu His
 1               5                  10                  15      
Arg Gln Phe Arg Gly Gly Pro Trp Ala Ser Gly Cys Pro Pro Pro Leu
            20                  25                  30          
Leu Tyr Lys Val Leu Ala Ser Gly Gln Pro Ala Gln Leu Pro Ser Leu
        35                  40                  45              
Arg Arg Arg Asp Ser Pro Val Pro Leu Thr Leu Ser Pro Ala Ala Pro
    50                  55                  60                  
Ala Gly Ser Ser Ala Gly Thr Met Gly Gly Arg Val Phe Leu Val Phe
65                  70                  75                  80  
Leu Ala Phe Cys Val Trp Leu Thr Leu Pro Gly Ala Glu Thr Gln Asp
                85                  90                  95      
Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln Asp Ser Ser Cys Val Asn
            100                 105                 110         
Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe Ser Ser Phe Ser Glu Ile
        115                 120                 125             
Ile Thr Thr Pro Met Glu Thr Cys Asp Asp Ile Asn Glu Cys Ala Thr
    130                 135                 140                 
Leu Ser Lys Val Ser Cys Gly Lys Phe Ser Asp Cys Trp Asn Thr Glu
145                 150                 155                 160 
Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly Tyr Glu Pro Val Ser Gly
                165                 170                 175     
Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn Thr Cys Gln Asp Met Thr
            180                 185                 190         
Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser Gln Thr Leu Ser
        195                 200                 205             
Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp Tyr Lys Pro Gly
    210                 215                 220                 
Leu Ala Asn Asn Thr Ile Gln Ser Ile Leu Gln Ala Leu Asp Glu Leu
225                 230                 235                 240 
Leu Glu Ala Pro Gly Asp Leu Glu Thr Leu Pro Arg Leu Gln Gln His
                245                 250                 255     
Cys Val Ala Ser His Leu Leu Asp Gly Leu Glu Asp Val Leu Arg Gly
            260                 265                 270         
Leu Ser Lys Asn Leu Ser Asn Gly Leu Leu Asn Phe Ser Tyr Pro Ala
        275                 280                 285             
Gly Thr Glu Leu Ser Leu Glu Val Gln Lys Gln Val Asp Arg Ser Val
    290                 295                 300                 
Thr Leu Arg Gln Asn Gln Ala Val Met Gln Leu Asp Trp Asn Gln Ala
305                 310                 315                 320 
Gln Lys Ser Gly Asp Pro Gly Pro Ser Val Val Gly Leu Val Ser Ile
                325                 330                 335     
Pro Gly Met Gly Lys Leu Leu Ala Glu Ala Pro Leu Val Leu Glu Pro
            340                 345                 350         
Glu Lys Gln Met Leu Leu His Glu Thr His Gln Gly Leu Leu Gln Asp
        355                 360                 365             
Gly Ser Pro Ile Leu Leu Ser Asp Val Ile Ser Ala Phe Leu Ser Asn
    370                 375                 380                 
Asn Asp Thr Gln Asn Leu Ser Ser Pro Val Thr Phe Thr Phe Ser His
385                 390                 395                 400 
Arg Ser Val Ile Pro Arg Gln Lys Val Leu Cys Val Phe Trp Glu His
                405                 410                 415     
Gly Gln Asn Gly Cys Gly His Trp Ala Thr Thr Gly Cys Ser Thr Ile
            420                 425                 430         
Gly Thr Arg Asp Thr Ser Thr Ile Cys Arg Cys Thr His Leu Ser Ser
        435                 440                 445             
Phe Ala Val Leu Met Ala His Tyr Asp Val Gln Glu Glu Asp Pro Val
    450                 455                 460                 
Leu Thr Val Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu
465                 470                 475                 480 
Leu Leu Ala Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr
                485                 490                 495     
Ser Thr Ser Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His
            500                 505                 510         
Leu Leu Phe Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys
        515                 520                 525             
Ser Ile Ile Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr
    530                 535                 540                 
Trp Met Leu Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu
545                 550                 555                 560 
Thr Val Val Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met
                565                 570                 575     
Phe Pro Val Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala
            580                 585                 590         
Ala Ser Arg Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln
        595                 600                 605             
Pro Glu Lys Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile
    610                 615                 620                 
Phe Ser Val Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys
625                 630                 635                 640 
Asn Arg Leu Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr
                645                 650                 655     
Arg Met Leu Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys
            660                 665                 670         
Thr Trp Cys Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met
        675                 680                 685             
Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe
    690                 695                 700                 
Leu Val Tyr Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys
705                 710                 715                 720 
Trp Ser Lys Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr
                725                 730                 735     
Leu Ser Ser Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn
            740                 745                 750         


<210> 9475
<211> 858
<212> PRT
<213> Homo sapiens

<400> 9475
Met Leu Ser His Leu Leu Thr His Thr Thr Gly Gly Gly Asp Glu Glu
 1               5                  10                  15      
Arg Gln Ser Leu Gly Lys Gly Glu Arg Lys Cys Val Leu Leu Phe Cys
            20                  25                  30          
Ile Phe Glu Gln Cys Ser Ile Val Gly Ser Val Leu Ile Phe Gly Gln
        35                  40                  45              
Val Arg Met Asn His Gln Lys Gly Arg Gly Pro Gly Arg Gln Pro Gln
    50                  55                  60                  
Glu Gly Leu Arg Ala Gly Pro Ser Pro Arg Ile Glu Ala Phe Pro Cys
65                  70                  75                  80  
Pro Pro Phe Gly Thr Arg Val Ser Ala Pro Pro Arg Ile Pro Arg Ile
                85                  90                  95      
Gly Glu Gly Arg Trp Ala Ser Glu Gly Ala Gly Leu Gly Glu Arg Arg
            100                 105                 110         
Leu Arg Glu Glu Arg Gly Arg Arg Gln Trp Thr Arg Arg Pro Arg Gly
        115                 120                 125             
Leu Glu Gly Glu Glu Ala Ala Val Trp Asp Gly Ala Gly Gly Asp Gln
    130                 135                 140                 
Thr Gln Glu Pro Pro Pro Gln His Pro Pro Ser Arg Ala Leu Pro Val
145                 150                 155                 160 
Gln Glu Arg Arg Val Arg Ser Asp Pro Glu Arg Cys Gly Tyr Lys Gly
                165                 170                 175     
Asp Gly Pro Ser Gly Ala Pro Ala Glu Pro Thr Arg Gln Phe Ala Ala
            180                 185                 190         
Ala Val Arg Leu Trp Glu Gln Glu Val Glu Gly Ile Arg Cys Gly Pro
        195                 200                 205             
Thr Lys Gly Glu Lys Pro Leu Leu Thr Val Pro Pro Tyr Val Leu Pro
    210                 215                 220                 
Ser His Ser Ile Leu Thr Ala Gln Leu Ser Pro Ser Thr Ala Ser Pro
225                 230                 235                 240 
Arg Pro Pro Ser Ser Ser Ala Trp Ile Ser Ser Leu Val Tyr Leu Lys
                245                 250                 255     
Thr Gln Gln Ala Arg Val Ser Glu Val Gly Phe Ile Phe Gly Thr Cys
            260                 265                 270         
Val Trp Ser Val Ala Gly Phe Ser Leu Arg Gln Ala His Pro Ser Ser
        275                 280                 285             
Lys Ile Glu Ser Leu Arg Val Thr Val Asp Phe Leu Lys Val Pro Leu
    290                 295                 300                 
Gly Leu Lys Lys Pro Val Leu Lys Glu Val Ala Val Gly Pro Pro Lys
305                 310                 315                 320 
Arg Pro Gln Pro Ala Ala Leu Glu Arg Tyr Lys Ala Arg Arg Ser Asp
                325                 330                 335     
Ala Met Asp Thr Glu Ser Gln Tyr Ser Gly Tyr Ser Tyr Lys Ser Gly
            340                 345                 350         
His Ser Arg Ser Ser Arg Lys His Arg Asp Arg Arg Asp Arg His Arg
        355                 360                 365             
Ser Lys Ser Arg Asp Gly Gly Arg Gly Asp Lys Ser Val Thr Ile Gln
    370                 375                 380                 
Ala Pro Gly Glu Pro Leu Leu Asp Asn Glu Ser Thr Arg Gly Asp Glu
385                 390                 395                 400 
Arg Asp Asp Asn Trp Gly Glu Thr Thr Thr Val Val Thr Gly Thr Ser
                405                 410                 415     
Glu His Ser Ile Ser His Asp Asp Leu Thr Arg Ile Ala Lys Asp Met
            420                 425                 430         
Glu Asp Ser Val Pro Leu Asp Cys Ser Arg His Leu Gly Val Ala Ala
        435                 440                 445             
Gly Ala Thr Leu Ala Leu Leu Ser Phe Leu Thr Pro Leu Ala Phe Leu
    450                 455                 460                 
Leu Leu Pro Pro Leu Leu Trp Arg Glu Glu Leu Glu Pro Cys Gly Thr
465                 470                 475                 480 
Ala Cys Glu Gly Leu Phe Ile Ser Val Ala Phe Lys Leu Leu Ile Leu
                485                 490                 495     
Leu Leu Gly Ser Trp Ala Leu Phe Phe Arg Arg Pro Lys Ala Ser Leu
            500                 505                 510         
Pro Arg Val Phe Val Leu Arg Ala Leu Leu Met Val Leu Val Phe Leu
        515                 520                 525             
Leu Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile Leu Asp Ala
    530                 535                 540                 
Arg Glu Arg Ser Tyr Gln Gly Val Val Gln Phe Ala Val Ser Leu Val
545                 550                 555                 560 
Asp Ala Leu Leu Phe Val His Tyr Leu Ala Val Val Leu Leu Glu Leu
                565                 570                 575     
Arg Gln Leu Gln Pro Gln Phe Thr Leu Lys Val Val Arg Ser Thr Asp
            580                 585                 590         
Gly Ala Ser Arg Phe Tyr Asn Val Gly His Leu Ser Ile Gln Arg Val
        595                 600                 605             
Ala Val Trp Ile Leu Glu Lys Tyr Tyr His Asp Phe Pro Val Tyr Asn
    610                 615                 620                 
Pro Ala Leu Leu Asn Leu Pro Lys Ser Val Leu Ala Lys Lys Val Ser
625                 630                 635                 640 
Gly Phe Lys Val Tyr Ser Leu Gly Glu Glu Asn Ser Thr Asn Asn Ser
                645                 650                 655     
Thr Gly Gln Ser Arg Ala Val Ile Ala Ala Ala Ala Arg Arg Arg Asp
            660                 665                 670         
Asn Ser His Asn Glu Tyr Tyr Tyr Glu Glu Ala Glu His Glu Arg Arg
        675                 680                 685             
Val Arg Lys Arg Arg Ala Arg Leu Val Val Ala Val Glu Glu Ala Phe
    690                 695                 700                 
Thr His Ile Lys Arg Leu Gln Glu Glu Glu Gln Lys Asn Pro Arg Glu
705                 710                 715                 720 
Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Ala Ser Met Ala
                725                 730                 735     
Arg Ala Met Gln Lys Tyr Leu Arg Thr Thr Lys Gln Gln Pro Tyr His
            740                 745                 750         
Thr Met Glu Ser Ile Leu Gln His Leu Glu Phe Cys Ile Thr His Asp
        755                 760                 765             
Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ala Ala Gly Pro Thr
    770                 775                 780                 
Ile Gln Tyr His Lys Glu Arg Trp Leu Ala Lys Gln Trp Thr Leu Val
785                 790                 795                 800 
Ser Glu Glu Pro Val Thr Asn Gly Leu Lys Asp Gly Ile Val Phe Leu
                805                 810                 815     
Leu Lys Arg Gln Asp Phe Ser Leu Val Val Ser Thr Lys Lys Val Pro
            820                 825                 830         
Phe Phe Lys Leu Ser Glu Glu Phe Val Asp Pro Lys Ser His Lys Phe
        835                 840                 845             
Val Met Arg Leu Gln Ser Glu Thr Ser Val
    850                 855             


<210> 9476
<211> 725
<212> PRT
<213> Homo sapiens

<400> 9476
Met Glu Pro Gly Asp Ala Ala Arg Pro Gly Ser Gly Arg Ala Thr Gly
 1               5                  10                  15      
Ala Pro Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Gly Trp Gly
            20                  25                  30          
Leu Arg Val Ala Ala Ala Ala Ser Ala Ser Ser Ser Gly Ala Ala Ala
        35                  40                  45              
Glu Asp Ser Ser Ala Met Glu Glu Leu Ala Thr Glu Lys Glu Ala Glu
    50                  55                  60                  
Glu Ser His Arg Gln Asp Ser Val Ser Leu Leu Thr Phe Ile Leu Leu
65                  70                  75                  80  
Leu Thr Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys His Arg Arg Val
                85                  90                  95      
Arg Phe Leu His Glu Thr Gly Leu Ala Met Ile Tyr Gly Leu Ile Val
            100                 105                 110         
Gly Val Ile Leu Arg Tyr Gly Thr Pro Ala Thr Ser Gly Arg Asp Lys
        115                 120                 125             
Ser Leu Ser Cys Thr Gln Glu Asp Arg Ala Phe Ser Thr Leu Leu Val
    130                 135                 140                 
Asn Val Ser Gly Lys Phe Phe Glu Tyr Thr Leu Lys Gly Glu Ile Ser
145                 150                 155                 160 
Pro Gly Lys Ile Asn Ser Val Glu Gln Asn Asp Met Leu Arg Lys Val
                165                 170                 175     
Thr Phe Asp Pro Glu Val Phe Phe Asn Ile Leu Leu Pro Pro Ile Ile
            180                 185                 190         
Phe His Ala Gly Tyr Ser Leu Lys Lys Arg His Phe Phe Arg Asn Leu
        195                 200                 205             
Gly Ser Ile Leu Ala Tyr Ala Phe Leu Gly Thr Ala Val Ser Cys Phe
    210                 215                 220                 
Ile Ile Gly Asn Leu Met Tyr Gly Val Val Lys Leu Met Lys Ile Met
225                 230                 235                 240 
Gly Gln Leu Ser Asp Lys Phe Tyr Tyr Thr Asp Cys Leu Phe Phe Gly
                245                 250                 255     
Ala Ile Ile Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe Asn
            260                 265                 270         
Glu Leu His Ala Asp Val Asp Leu Tyr Ala Leu Leu Phe Gly Glu Ser
        275                 280                 285             
Val Leu Asn Asp Ala Val Ala Ile Val Leu Ser Ser Ser Ile Val Ala
    290                 295                 300                 
Tyr Gln Pro Ala Gly Leu Asn Thr His Ala Phe Asp Ala Ala Ala Phe
305                 310                 315                 320 
Phe Lys Ser Val Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Thr
                325                 330                 335     
Met Gly Ala Val Thr Gly Val Asn Ala Asn Val Thr Lys Phe Thr Lys
            340                 345                 350         
Leu His Cys Phe Pro Leu Leu Glu Thr Ala Leu Phe Phe Leu Met Ser
        355                 360                 365             
Trp Ser Thr Phe Leu Leu Ala Glu Ala Cys Gly Phe Thr Gly Val Val
    370                 375                 380                 
Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Tyr Asn Asn
385                 390                 395                 400 
Leu Ser Val Glu Ser Arg Ser Arg Thr Lys Gln Leu Phe Glu Val Leu
                405                 410                 415     
His Phe Leu Ala Glu Asn Phe Ile Phe Ser Tyr Met Gly Leu Ala Leu
            420                 425                 430         
Phe Thr Phe Gln Lys His Val Phe Ser Pro Ile Phe Ile Ile Gly Ala
        435                 440                 445             
Phe Val Ala Ile Phe Leu Gly Arg Ala Ala His Ile Tyr Pro Leu Ser
    450                 455                 460                 
Phe Phe Leu Asn Leu Gly Arg Arg His Lys Ile Gly Trp Asn Phe Gln
465                 470                 475                 480 
His Met Met Met Phe Ser Gly Leu Arg Gly Ala Met Ala Phe Ala Leu
                485                 490                 495     
Ala Ile Arg Asp Thr Ala Ser Tyr Ala Arg Gln Met Met Phe Thr Thr
            500                 505                 510         
Thr Leu Leu Ile Val Phe Phe Thr Val Trp Ile Ile Gly Gly Gly Thr
        515                 520                 525             
Thr Pro Met Leu Ser Trp Leu Asn Ile Arg Val Gly Val Glu Glu Pro
    530                 535                 540                 
Ser Glu Glu Asp Gln Asn Glu His His Trp Gln Tyr Phe Arg Val Gly
545                 550                 555                 560 
Val Asp Pro Asp Gln Asp Pro Pro Pro Asn Asn Asp Ser Phe Gln Val
                565                 570                 575     
Leu Gln Gly Asp Gly Pro Asp Ser Ala Arg Gly Asn Arg Thr Lys Gln
            580                 585                 590         
Glu Ser Ala Trp Ile Phe Arg Leu Trp Tyr Ser Phe Asp His Asn Tyr
        595                 600                 605             
Leu Lys Pro Ile Leu Thr His Ser Gly Pro Pro Leu Thr Thr Thr Leu
    610                 615                 620                 
Pro Ala Trp Cys Gly Leu Leu Ala Arg Cys Leu Thr Ser Pro Gln Val
625                 630                 635                 640 
Tyr Asp Asn Gln Glu Pro Leu Arg Glu Glu Asp Ser Asp Phe Ile Leu
                645                 650                 655     
Thr Glu Gly Asp Leu Thr Leu Thr Tyr Gly Asp Ser Thr Val Thr Ala
            660                 665                 670         
Asn Gly Ser Ser Ser Ser His Thr Ala Ser Thr Ser Leu Glu Gly Ser
        675                 680                 685             
Arg Arg Thr Lys Ser Ser Ser Glu Glu Val Leu Glu Arg Asp Leu Gly
    690                 695                 700                 
Met Gly Asp Gln Lys Val Ser Ser Arg Gly Thr Arg Leu Val Phe Pro
705                 710                 715                 720 
Leu Glu Asp Asn Ala
                725 


<210> 9477
<211> 1513
<212> PRT
<213> Homo sapiens

<400> 9477
Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn
 1               5                  10                  15      
Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val
            20                  25                  30          
Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly
        35                  40                  45              
Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu
    50                  55                  60                  
His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu
65                  70                  75                  80  
Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg
                85                  90                  95      
Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe
            100                 105                 110         
Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser
        115                 120                 125             
Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala
    130                 135                 140                 
Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu
145                 150                 155                 160 
Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu
                165                 170                 175     
Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg
            180                 185                 190         
Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu
        195                 200                 205             
Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser
    210                 215                 220                 
Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys
225                 230                 235                 240 
Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg
                245                 250                 255     
Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys
            260                 265                 270         
Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala
        275                 280                 285             
Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg
    290                 295                 300                 
Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly
305                 310                 315                 320 
Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr
                325                 330                 335     
Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr
            340                 345                 350         
Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe
        355                 360                 365             
Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg
    370                 375                 380                 
Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr
385                 390                 395                 400 
Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu
                405                 410                 415     
Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro
            420                 425                 430         
Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu
        435                 440                 445             
Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val
    450                 455                 460                 
Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala
465                 470                 475                 480 
Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn
                485                 490                 495     
Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His
            500                 505                 510         
Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser
        515                 520                 525             
Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala
    530                 535                 540                 
Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr
545                 550                 555                 560 
Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser
                565                 570                 575     
Leu Phe His Ile Leu Val Thr Pro Leu Ser Leu Leu Phe Thr Val Val
            580                 585                 590         
Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe
        595                 600                 605             
Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser
    610                 615                 620                 
Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Val Thr Asn
625                 630                 635                 640 
Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu Ser Asn Ile Asp
                645                 650                 655     
Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val Gly Gln Val Gly
            660                 665                 670         
Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly Glu Met Gln Thr
        675                 680                 685             
Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu Ser Glu Pro Ser
    690                 695                 700                 
Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val Ala Tyr Ala Ala
705                 710                 715                 720 
Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu Asn Ile Thr Phe
                725                 730                 735     
Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val Thr Asp Ala Cys
            740                 745                 750         
Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly Asp Gln Thr Glu
        755                 760                 765             
Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln Arg Gln Arg Ile
    770                 775                 780                 
Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile Val Phe Leu Asp
785                 790                 795                 800 
Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp His Leu Met Gln
                805                 810                 815     
Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg Thr Leu Val Leu
            820                 825                 830         
Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp Trp Ile Ile Ala
        835                 840                 845             
Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu Lys Asp Ile Gln
    850                 855                 860                 
Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr Leu Met Asn Arg
865                 870                 875                 880 
Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp Gln Thr Thr Leu
                885                 890                 895     
Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg Glu Ala Lys Ala
            900                 905                 910         
Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp
        915                 920                 925             
Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys Met Pro Trp Lys
    930                 935                 940                 
Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe Leu Leu Ile Leu
945                 950                 955                 960 
Met Ile Phe Ser Lys Leu Leu Lys His Ser Val Ile Val Ala Ile Asp
                965                 970                 975     
Tyr Trp Leu Ala Thr Trp Thr Ser Glu Tyr Ser Ile Asn Asn Thr Gly
            980                 985                 990         
Lys Ala Asp Gln Thr Tyr Tyr Val Ala Gly Phe Ser Ile Leu Cys Gly
        995                 1000                1005            
Ala Gly Ile Phe Leu Cys Leu Val Thr Ser Leu Thr Val Glu Trp Met
    1010                1015                1020                
Gly Leu Thr Ala Ala Lys Asn Leu His His Asn Leu Leu Asn Lys Ile
1025                1030                1035                1040
Ile Leu Gly Pro Ile Arg Phe Phe Asp Thr Thr Pro Leu Gly Leu Ile
                1045                1050                1055    
Leu Asn Arg Phe Ser Ala Asp Thr Asn Ile Ile Asp Gln His Ile Pro
            1060                1065                1070        
Pro Thr Leu Glu Ser Leu Thr Arg Ser Thr Leu Leu Cys Leu Ser Ala
        1075                1080                1085            
Ile Gly Met Ile Ser Tyr Ala Thr Pro Val Phe Leu Val Ala Leu Leu
    1090                1095                1100                
Pro Leu Gly Val Ala Phe Tyr Phe Ile Gln Lys Tyr Phe Arg Val Ala
1105                1110                1115                1120
Ser Lys Asp Leu Gln Glu Leu Asp Asp Ser Thr Gln Leu Pro Leu Leu
                1125                1130                1135    
Cys His Phe Ser Glu Thr Ala Glu Gly Leu Thr Thr Ile Arg Ala Phe
            1140                1145                1150        
Arg His Glu Thr Arg Phe Lys Gln Arg Met Leu Glu Leu Thr Asp Thr
        1155                1160                1165            
Asn Asn Ile Ala Tyr Leu Phe Leu Ser Ala Ala Asn Arg Trp Leu Glu
    1170                1175                1180                
Val Arg Thr Asp Tyr Leu Gly Ala Cys Ile Val Leu Thr Ala Ser Ile
1185                1190                1195                1200
Ala Ser Ile Ser Gly Ser Ser Asn Ser Gly Leu Val Gly Leu Gly Leu
                1205                1210                1215    
Leu Tyr Ala Leu Thr Ile Thr Asn Tyr Leu Asn Trp Val Val Arg Asn
            1220                1225                1230        
Leu Ala Asp Leu Glu Val Gln Met Gly Ala Val Lys Lys Val Asn Ser
        1235                1240                1245            
Phe Leu Thr Met Glu Ser Glu Asn Tyr Glu Gly Thr Met Asp Pro Ser
    1250                1255                1260                
Gln Val Pro Glu His Trp Pro Gln Glu Gly Glu Ile Lys Ile His Asp
1265                1270                1275                1280
Leu Cys Val Arg Tyr Glu Asn Asn Leu Lys Pro Val Leu Lys His Val
                1285                1290                1295    
Lys Ala Tyr Ile Lys Pro Gly Gln Lys Val Gly Ile Cys Gly Arg Thr
            1300                1305                1310        
Gly Ser Gly Lys Ser Ser Leu Ser Leu Ala Phe Phe Arg Met Val Asp
        1315                1320                1325            
Ile Phe Asp Gly Lys Ile Val Ile Asp Gly Ile Asp Ile Ser Lys Leu
    1330                1335                1340                
Pro Leu His Thr Leu Arg Ser Arg Leu Ser Ile Ile Leu Gln Asp Pro
1345                1350                1355                1360
Ile Leu Phe Ser Gly Ser Ile Arg Phe Asn Leu Asp Pro Glu Cys Lys
                1365                1370                1375    
Cys Thr Asp Asp Arg Leu Trp Glu Ala Leu Glu Ile Ala Gln Leu Lys
            1380                1385                1390        
Asn Met Val Lys Ser Leu Pro Gly Gly Leu Asp Ala Val Val Thr Glu
        1395                1400                1405            
Gly Gly Glu Asn Phe Ser Val Gly Gln Arg Gln Leu Phe Cys Leu Ala
    1410                1415                1420                
Arg Ala Phe Val Arg Lys Ser Ser Ile Leu Ile Met Asp Glu Ala Thr
1425                1430                1435                1440
Ala Ser Ile Asp Met Ala Thr Glu Asn Ile Leu Gln Lys Val Val Met
                1445                1450                1455    
Thr Ala Phe Ala Asp Arg Thr Val Val Thr Met Ala His Arg Val Ser
            1460                1465                1470        
Ser Ile Met Asp Ala Gly Leu Val Leu Val Phe Ser Glu Gly Ile Leu
        1475                1480                1485            
Val Glu Cys Asp Thr Val Pro Asn Leu Phe Ala His Lys Asn Gly Pro
    1490                1495                1500                
Phe Ser Thr Leu Val Met Thr Asn Lys
1505                1510            


<210> 9478
<211> 1549
<212> PRT
<213> Homo sapiens

<400> 9478
Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn
 1               5                  10                  15      
Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val
            20                  25                  30          
Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly
        35                  40                  45              
Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu
    50                  55                  60                  
His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu
65                  70                  75                  80  
Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg
                85                  90                  95      
Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe
            100                 105                 110         
Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser
        115                 120                 125             
Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala
    130                 135                 140                 
Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu
145                 150                 155                 160 
Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu
                165                 170                 175     
Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg
            180                 185                 190         
Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu
        195                 200                 205             
Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser
    210                 215                 220                 
Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys
225                 230                 235                 240 
Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg
                245                 250                 255     
Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys
            260                 265                 270         
Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala
        275                 280                 285             
Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg
    290                 295                 300                 
Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly
305                 310                 315                 320 
Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr
                325                 330                 335     
Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr
            340                 345                 350         
Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe
        355                 360                 365             
Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg
    370                 375                 380                 
Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr
385                 390                 395                 400 
Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu
                405                 410                 415     
Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro
            420                 425                 430         
Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu
        435                 440                 445             
Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val
    450                 455                 460                 
Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala
465                 470                 475                 480 
Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn
                485                 490                 495     
Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His
            500                 505                 510         
Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser
        515                 520                 525             
Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala
    530                 535                 540                 
Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr
545                 550                 555                 560 
Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser
                565                 570                 575     
Leu Phe His Ile Leu Val Thr Pro Leu Ser Leu Leu Phe Thr Val Val
            580                 585                 590         
Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe
        595                 600                 605             
Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser
    610                 615                 620                 
Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys
625                 630                 635                 640 
Thr Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu
                645                 650                 655     
Gln Ser Thr Arg Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile
            660                 665                 670         
Lys Val Thr Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu
        675                 680                 685             
Ser Asn Ile Asp Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val
    690                 695                 700                 
Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly
705                 710                 715                 720 
Glu Met Gln Thr Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu
                725                 730                 735     
Ser Glu Pro Ser Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val
            740                 745                 750         
Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu
        755                 760                 765             
Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val
    770                 775                 780                 
Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly
785                 790                 795                 800 
Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln
                805                 810                 815     
Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile
            820                 825                 830         
Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp
        835                 840                 845             
His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg
    850                 855                 860                 
Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp
865                 870                 875                 880 
Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu
                885                 890                 895     
Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr
            900                 905                 910         
Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp
        915                 920                 925             
Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg
    930                 935                 940                 
Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu
945                 950                 955                 960 
Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys
                965                 970                 975     
Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe
            980                 985                 990         
Leu Leu Ile Leu Met Ile Phe Ser Lys Leu Leu Lys His Ser Val Ile
        995                 1000                1005            
Val Ala Ile Asp Tyr Trp Leu Ala Thr Trp Thr Ser Glu Tyr Ser Ile
    1010                1015                1020                
Asn Asn Thr Gly Lys Ala Asp Gln Thr Tyr Tyr Val Ala Gly Phe Ser
1025                1030                1035                1040
Ile Leu Cys Gly Ala Gly Ile Phe Leu Cys Leu Val Thr Ser Leu Thr
                1045                1050                1055    
Val Glu Trp Met Gly Leu Thr Ala Ala Lys Asn Leu His His Asn Leu
            1060                1065                1070        
Leu Asn Lys Ile Ile Leu Gly Pro Ile Arg Phe Phe Asp Thr Thr Pro
        1075                1080                1085            
Leu Gly Leu Ile Leu Asn Arg Phe Ser Ala Asp Thr Asn Ile Ile Asp
    1090                1095                1100                
Gln His Ile Pro Pro Thr Leu Glu Ser Leu Thr Arg Ser Thr Leu Leu
1105                1110                1115                1120
Cys Leu Ser Ala Ile Gly Met Ile Ser Tyr Ala Thr Pro Val Phe Leu
                1125                1130                1135    
Val Ala Leu Leu Pro Leu Gly Val Ala Phe Tyr Phe Ile Gln Lys Tyr
            1140                1145                1150        
Phe Arg Val Ala Ser Lys Asp Leu Gln Glu Leu Asp Asp Ser Thr Gln
        1155                1160                1165            
Leu Pro Leu Leu Cys His Phe Ser Glu Thr Ala Glu Gly Leu Thr Thr
    1170                1175                1180                
Ile Arg Ala Phe Arg His Glu Thr Arg Phe Lys Gln Arg Met Leu Glu
1185                1190                1195                1200
Leu Thr Asp Thr Asn Asn Ile Ala Tyr Leu Phe Leu Ser Ala Ala Asn
                1205                1210                1215    
Arg Trp Leu Glu Val Arg Thr Asp Tyr Leu Gly Ala Cys Ile Val Leu
            1220                1225                1230        
Thr Ala Ser Ile Ala Ser Ile Ser Gly Ser Ser Asn Ser Gly Leu Val
        1235                1240                1245            
Gly Leu Gly Leu Leu Tyr Ala Leu Thr Ile Thr Asn Tyr Leu Asn Trp
    1250                1255                1260                
Val Val Arg Asn Leu Ala Asp Leu Glu Val Gln Met Gly Ala Val Lys
1265                1270                1275                1280
Lys Val Asn Ser Phe Leu Thr Met Glu Ser Glu Asn Tyr Glu Gly Thr
                1285                1290                1295    
Met Asp Pro Ser Gln Val Pro Glu His Trp Pro Gln Glu Gly Glu Ile
            1300                1305                1310        
Lys Ile His Asp Leu Cys Val Arg Tyr Glu Asn Asn Leu Lys Pro Val
        1315                1320                1325            
Leu Lys His Val Lys Ala Tyr Ile Lys Pro Gly Gln Lys Val Gly Ile
    1330                1335                1340                
Cys Gly Arg Thr Gly Ser Gly Lys Ser Ser Leu Ser Leu Ala Phe Phe
1345                1350                1355                1360
Arg Met Val Asp Ile Phe Asp Gly Lys Ile Val Ile Asp Gly Ile Asp
                1365                1370                1375    
Ile Ser Lys Leu Pro Leu His Thr Leu Arg Ser Arg Leu Ser Ile Ile
            1380                1385                1390        
Leu Gln Asp Pro Ile Leu Phe Ser Gly Ser Ile Arg Phe Asn Leu Asp
        1395                1400                1405            
Pro Glu Cys Lys Cys Thr Asp Asp Arg Leu Trp Glu Ala Leu Glu Ile
    1410                1415                1420                
Ala Gln Leu Lys Asn Met Val Lys Ser Leu Pro Gly Gly Leu Asp Ala
1425                1430                1435                1440
Val Val Thr Glu Gly Gly Glu Asn Phe Ser Val Gly Gln Arg Gln Leu
                1445                1450                1455    
Phe Cys Leu Ala Arg Ala Phe Val Arg Lys Ser Ser Ile Leu Ile Met
            1460                1465                1470        
Asp Glu Ala Thr Ala Ser Ile Asp Met Ala Thr Glu Asn Ile Leu Gln
        1475                1480                1485            
Lys Val Val Met Thr Ala Phe Ala Asp Arg Thr Val Val Thr Met Ala
    1490                1495                1500                
His Arg Val Ser Ser Ile Met Asp Ala Gly Leu Val Leu Val Phe Ser
1505                1510                1515                1520
Glu Gly Ile Leu Val Glu Cys Asp Thr Val Pro Asn Leu Phe Ala His
                1525                1530                1535    
Lys Asn Gly Pro Phe Ser Thr Leu Val Met Thr Asn Lys
            1540                1545                


<210> 9479
<211> 1549
<212> PRT
<213> Homo sapiens

<400> 9479
Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn
 1               5                  10                  15      
Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val
            20                  25                  30          
Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly
        35                  40                  45              
Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu
    50                  55                  60                  
His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu
65                  70                  75                  80  
Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg
                85                  90                  95      
Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe
            100                 105                 110         
Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser
        115                 120                 125             
Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala
    130                 135                 140                 
Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu
145                 150                 155                 160 
Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu
                165                 170                 175     
Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg
            180                 185                 190         
Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu
        195                 200                 205             
Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser
    210                 215                 220                 
Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys
225                 230                 235                 240 
Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg
                245                 250                 255     
Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys
            260                 265                 270         
Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala
        275                 280                 285             
Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg
    290                 295                 300                 
Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly
305                 310                 315                 320 
Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr
                325                 330                 335     
Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr
            340                 345                 350         
Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe
        355                 360                 365             
Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg
    370                 375                 380                 
Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr
385                 390                 395                 400 
Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu
                405                 410                 415     
Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro
            420                 425                 430         
Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu
        435                 440                 445             
Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val
    450                 455                 460                 
Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala
465                 470                 475                 480 
Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn
                485                 490                 495     
Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His
            500                 505                 510         
Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser
        515                 520                 525             
Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala
    530                 535                 540                 
Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr
545                 550                 555                 560 
Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser
                565                 570                 575     
Leu Phe His Ile Leu Val Thr Pro Leu Ser Leu Leu Phe Thr Val Val
            580                 585                 590         
Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe
        595                 600                 605             
Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser
    610                 615                 620                 
Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys
625                 630                 635                 640 
Thr Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu
                645                 650                 655     
Gln Ser Thr Arg Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile
            660                 665                 670         
Lys Val Thr Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu
        675                 680                 685             
Ser Asn Ile Asp Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val
    690                 695                 700                 
Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly
705                 710                 715                 720 
Glu Met Gln Thr Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu
                725                 730                 735     
Ser Glu Pro Ser Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val
            740                 745                 750         
Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu
        755                 760                 765             
Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val
    770                 775                 780                 
Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly
785                 790                 795                 800 
Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln
                805                 810                 815     
Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile
            820                 825                 830         
Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp
        835                 840                 845             
His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg
    850                 855                 860                 
Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp
865                 870                 875                 880 
Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu
                885                 890                 895     
Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr
            900                 905                 910         
Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp
        915                 920                 925             
Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg
    930                 935                 940                 
Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu
945                 950                 955                 960 
Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys
                965                 970                 975     
Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe
            980                 985                 990         
Leu Leu Ile Leu Met Ile Phe Ser Lys Leu Leu Lys His Ser Val Ile
        995                 1000                1005            
Val Ala Ile Asp Tyr Trp Leu Ala Thr Trp Thr Ser Glu Tyr Ser Ile
    1010                1015                1020                
Asn Asn Thr Gly Lys Ala Asp Gln Thr Tyr Tyr Val Ala Gly Phe Ser
1025                1030                1035                1040
Ile Leu Cys Gly Ala Gly Ile Phe Leu Cys Leu Val Thr Ser Leu Thr
                1045                1050                1055    
Val Glu Trp Met Gly Leu Thr Ala Ala Lys Asn Leu His His Asn Leu
            1060                1065                1070        
Leu Asn Lys Ile Ile Leu Gly Pro Ile Arg Phe Phe Asp Thr Thr Pro
        1075                1080                1085            
Leu Gly Leu Ile Leu Asn Arg Phe Ser Ala Asp Thr Asn Ile Ile Asp
    1090                1095                1100                
Gln His Ile Pro Pro Thr Leu Glu Ser Leu Thr Arg Ser Thr Leu Leu
1105                1110                1115                1120
Cys Leu Ser Ala Ile Gly Met Ile Ser Tyr Ala Thr Pro Val Phe Leu
                1125                1130                1135    
Val Ala Leu Leu Pro Leu Gly Val Ala Phe Tyr Phe Ile Gln Lys Tyr
            1140                1145                1150        
Phe Arg Val Ala Ser Lys Asp Leu Gln Glu Leu Asp Asp Ser Thr Gln
        1155                1160                1165            
Leu Pro Leu Leu Cys His Phe Ser Glu Thr Ala Glu Gly Leu Thr Thr
    1170                1175                1180                
Ile Arg Ala Phe Arg His Glu Thr Arg Phe Lys Gln Arg Met Leu Glu
1185                1190                1195                1200
Leu Thr Asp Thr Asn Asn Ile Ala Tyr Leu Phe Leu Ser Ala Ala Asn
                1205                1210                1215    
Arg Trp Leu Glu Val Arg Thr Asp Tyr Leu Gly Ala Cys Ile Val Leu
            1220                1225                1230        
Thr Ala Ser Ile Ala Ser Ile Ser Gly Ser Ser Asn Ser Gly Leu Val
        1235                1240                1245            
Gly Leu Gly Leu Leu Tyr Ala Leu Thr Ile Thr Asn Tyr Leu Asn Trp
    1250                1255                1260                
Val Val Arg Asn Leu Ala Asp Leu Glu Val Gln Met Gly Ala Val Lys
1265                1270                1275                1280
Lys Val Asn Ser Phe Leu Thr Met Glu Ser Glu Asn Tyr Glu Gly Thr
                1285                1290                1295    
Met Asp Pro Ser Gln Val Pro Glu His Trp Pro Gln Glu Gly Glu Ile
            1300                1305                1310        
Lys Ile His Asp Leu Cys Val Arg Tyr Glu Asn Asn Leu Lys Pro Val
        1315                1320                1325            
Leu Lys His Val Lys Ala Tyr Ile Lys Pro Gly Gln Lys Val Gly Ile
    1330                1335                1340                
Cys Gly Arg Thr Gly Ser Gly Lys Ser Ser Leu Ser Leu Ala Phe Phe
1345                1350                1355                1360
Arg Met Val Asp Ile Phe Asp Gly Lys Ile Val Ile Asp Gly Ile Asp
                1365                1370                1375    
Ile Ser Lys Leu Pro Leu His Thr Leu Arg Ser Arg Leu Ser Ile Ile
            1380                1385                1390        
Leu Gln Asp Pro Ile Leu Phe Ser Gly Ser Ile Arg Phe Asn Leu Asp
        1395                1400                1405            
Pro Glu Cys Lys Cys Thr Asp Asp Arg Leu Trp Glu Ala Leu Glu Ile
    1410                1415                1420                
Ala Gln Leu Lys Asn Met Val Lys Ser Leu Pro Gly Gly Leu Asp Ala
1425                1430                1435                1440
Val Val Thr Glu Gly Gly Glu Asn Phe Ser Val Gly Gln Arg Gln Leu
                1445                1450                1455    
Phe Cys Leu Ala Arg Ala Phe Val Arg Lys Ser Ser Ile Leu Ile Met
            1460                1465                1470        
Asp Glu Ala Thr Ala Ser Ile Asp Met Ala Thr Glu Asn Ile Leu Gln
        1475                1480                1485            
Lys Val Val Met Thr Ala Phe Ala Asp Arg Thr Val Val Thr Met Ala
    1490                1495                1500                
His Arg Val His Thr Ile Leu Thr Ala Asp Leu Val Ile Val Met Lys
1505                1510                1515                1520
Arg Gly Asn Ile Leu Glu Tyr Asp Thr Pro Glu Ser Leu Leu Ala Gln
                1525                1530                1535    
Glu Asn Gly Val Phe Ala Ser Phe Val Arg Ala Asp Met
            1540                1545                


<210> 9480
<211> 685
<212> PRT
<213> Homo sapiens

<400> 9480
Met Ala Glu Asp Lys Ser Lys Arg Asp Ser Ile Glu Met Ser Met Lys
 1               5                  10                  15      
Gly Cys Gln Thr Asn Asn Gly Phe Val His Asn Glu Asp Ile Leu Glu
            20                  25                  30          
Gln Thr Pro Asp Pro Gly Ser Ser Thr Asp Asn Leu Lys His Ser Thr
        35                  40                  45              
Arg Gly Ile Leu Gly Ser Gln Glu Pro Asp Phe Lys Gly Val Gln Pro
    50                  55                  60                  
Tyr Ala Gly Met Pro Lys Glu Val Leu Phe Gln Phe Ser Gly Gln Ala
65                  70                  75                  80  
Arg Tyr Arg Ile Pro Arg Glu Ile Leu Phe Trp Leu Thr Val Ala Ser
                85                  90                  95      
Val Leu Val Leu Ile Ala Ala Thr Ile Ala Ile Ile Ala Leu Ser Pro
            100                 105                 110         
Lys Cys Leu Asp Trp Trp Gln Glu Gly Pro Met Tyr Gln Ile Tyr Pro
        115                 120                 125             
Arg Ser Phe Lys Asp Ser Asn Lys Asp Gly Asn Gly Asp Leu Lys Gly
    130                 135                 140                 
Ile Gln Asp Lys Leu Asp Tyr Ile Thr Ala Leu Asn Ile Lys Thr Val
145                 150                 155                 160 
Trp Ile Thr Ser Phe Tyr Lys Ser Ser Leu Lys Asp Phe Arg Tyr Gly
                165                 170                 175     
Val Glu Asp Phe Arg Glu Val Asp Pro Ile Phe Gly Thr Met Glu Asp
            180                 185                 190         
Phe Glu Asn Leu Val Ala Ala Ile His Asp Lys Gly Leu Lys Leu Ile
        195                 200                 205             
Ile Asp Phe Ile Pro Asn His Thr Ser Asp Lys His Ile Trp Phe Gln
    210                 215                 220                 
Leu Ser Arg Thr Arg Thr Gly Lys Tyr Thr Asp Tyr Tyr Ile Trp His
225                 230                 235                 240 
Asp Cys Thr His Glu Asn Gly Lys Thr Ile Pro Pro Asn Asn Trp Leu
                245                 250                 255     
Ser Val Tyr Gly Asn Ser Ser Trp His Phe Asp Glu Val Arg Asn Gln
            260                 265                 270         
Cys Tyr Phe His Gln Phe Met Lys Glu Gln Pro Asp Leu Asn Phe Arg
        275                 280                 285             
Asn Pro Asp Val Gln Glu Glu Ile Lys Glu Ile Leu Arg Phe Trp Leu
    290                 295                 300                 
Thr Lys Gly Val Asp Gly Phe Ser Leu Asp Ala Val Lys Phe Leu Leu
305                 310                 315                 320 
Glu Ala Lys His Leu Arg Asp Glu Ile Gln Val Asn Lys Thr Gln Ile
                325                 330                 335     
Pro Asp Thr Val Thr Gln Tyr Ser Glu Leu Tyr His Asp Phe Thr Thr
            340                 345                 350         
Thr Gln Val Gly Met His Asp Ile Val Arg Ser Phe Arg Gln Thr Met
        355                 360                 365             
Asp Gln Tyr Ser Thr Glu Pro Gly Arg Tyr Arg Phe Met Gly Thr Glu
    370                 375                 380                 
Ala Tyr Ala Glu Ser Ile Asp Arg Thr Val Met Tyr Tyr Gly Leu Pro
385                 390                 395                 400 
Phe Ile Gln Glu Ala Asp Phe Pro Phe Asn Asn Tyr Leu Ser Met Leu
                405                 410                 415     
Asp Thr Val Ser Gly Asn Ser Val Tyr Glu Val Ile Thr Ser Trp Met
            420                 425                 430         
Glu Asn Met Pro Glu Gly Lys Trp Pro Asn Trp Met Ile Gly Gly Pro
        435                 440                 445             
Asp Ser Ser Arg Leu Thr Ser Arg Leu Gly Asn Gln Tyr Val Asn Val
    450                 455                 460                 
Met Asn Met Leu Leu Phe Thr Leu Pro Gly Thr Pro Ile Thr Tyr Tyr
465                 470                 475                 480 
Gly Glu Glu Ile Gly Met Gly Asn Ile Val Ala Ala Asn Leu Asn Glu
                485                 490                 495     
Ser Tyr Asp Ile Asn Thr Leu Arg Ser Lys Ser Pro Met Gln Trp Asp
            500                 505                 510         
Asn Ser Ser Asn Ala Gly Phe Ser Glu Ala Ser Asn Thr Trp Leu Pro
        515                 520                 525             
Thr Asn Ser Asp Tyr His Thr Val Asn Val Asp Val Gln Lys Thr Gln
    530                 535                 540                 
Pro Arg Ser Ala Leu Lys Leu Tyr Gln Asp Leu Ser Leu Leu His Ala
545                 550                 555                 560 
Asn Glu Leu Leu Leu Asn Arg Gly Trp Phe Cys His Leu Arg Asn Asp
                565                 570                 575     
Ser His Tyr Val Val Tyr Thr Arg Glu Leu Asp Gly Ile Asp Arg Ile
            580                 585                 590         
Phe Ile Val Val Leu Asn Phe Gly Glu Ser Thr Leu Leu Asn Leu His
        595                 600                 605             
Asn Met Ile Ser Gly Leu Pro Ala Lys Ile Arg Ile Arg Leu Ser Thr
    610                 615                 620                 
Asn Ser Ala Asp Lys Gly Ser Lys Val Asp Thr Ser Gly Ile Phe Leu
625                 630                 635                 640 
Asp Lys Gly Glu Gly Leu Ile Phe Glu His Asn Thr Lys Asn Leu Leu
                645                 650                 655     
His Arg Gln Thr Ala Phe Arg Asp Arg Cys Phe Val Ser Asn Arg Ala
            660                 665                 670         
Cys Tyr Ser Ser Val Leu Asn Ile Leu Tyr Thr Ser Cys
        675                 680                 685 


<210> 9481
<211> 1422
<212> PRT
<213> Homo sapiens

<400> 9481
Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly
 1               5                  10                  15      
Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys
            20                  25                  30          
Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala
        35                  40                  45              
Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu
    50                  55                  60                  
Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro
65                  70                  75                  80  
Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu
                85                  90                  95      
Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly
            100                 105                 110         
Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr
        115                 120                 125             
Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro
    130                 135                 140                 
Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys
145                 150                 155                 160 
Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys
                165                 170                 175     
Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys
            180                 185                 190         
Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn
        195                 200                 205             
Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu
    210                 215                 220                 
Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys
225                 230                 235                 240 
Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys
                245                 250                 255     
Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser
            260                 265                 270         
Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys
        275                 280                 285             
Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr
    290                 295                 300                 
Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys
305                 310                 315                 320 
Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu
                325                 330                 335     
Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu
            340                 345                 350         
Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu
        355                 360                 365             
Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp
    370                 375                 380                 
Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser
385                 390                 395                 400 
Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn
                405                 410                 415     
Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg
            420                 425                 430         
Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn
        435                 440                 445             
Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu
    450                 455                 460                 
Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp
465                 470                 475                 480 
Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly
                485                 490                 495     
Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg
            500                 505                 510         
Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala
        515                 520                 525             
Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu
    530                 535                 540                 
Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp
545                 550                 555                 560 
Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala
                565                 570                 575     
Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile
            580                 585                 590         
Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr
        595                 600                 605             
Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser
    610                 615                 620                 
Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His
625                 630                 635                 640 
Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val
                645                 650                 655     
Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Thr Tyr Met Met
            660                 665                 670         
Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser
        675                 680                 685             
Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln
    690                 695                 700                 
Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys
705                 710                 715                 720 
Val Pro Val Gln Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser
                725                 730                 735     
Leu Gln Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile
            740                 745                 750         
Leu Leu Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp
        755                 760                 765             
Ile Ile Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val
    770                 775                 780                 
Ile Glu Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala
785                 790                 795                 800 
Met Pro Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile
                805                 810                 815     
Asn Gln Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp
            820                 825                 830         
Thr Thr Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser
        835                 840                 845             
Lys Ala Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val
    850                 855                 860                 
Pro Phe Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val
865                 870                 875                 880 
Ile Gly Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr
                885                 890                 895     
Asn Arg Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln
            900                 905                 910         
Ala Ser Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu
        915                 920                 925             
Ala Thr Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn
    930                 935                 940                 
Gly Ile Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val
945                 950                 955                 960 
Lys Val Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro
                965                 970                 975     
Val Val Asn Gln Val Lys Val Leu Thr Glu Ser Asn Arg Ile Ser His
            980                 985                 990         
His Lys Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His
        995                 1000                1005            
Pro Leu Gly Thr Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr
    1010                1015                1020                
Glu Thr Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly
1025                1030                1035                1040
Ile Ser Cys Lys Val Thr Asn Ile Glu Gly Leu Leu His Lys Asn Asn
                1045                1050                1055    
Trp Asn Ile Glu Asp Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile
            1060                1065                1070        
Asp Ala Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met Ile Ile Asp
        1075                1080                1085            
Ala Gln Ile Ser Asn Ala Leu Asn Ala Gln Gln His Lys Val Leu Ile
    1090                1095                1100                
Gly Asn Arg Glu Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp
1105                1110                1115                1120
Val Asn Asp Phe Met Thr Glu His Glu Arg Lys Gly Arg Thr Ala Val
                1125                1130                1135    
Leu Val Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp
            1140                1145                1150        
Thr Val Lys Pro Glu Ala Glu Leu Ala Ile His Ile Leu Lys Ser Met
        1155                1160                1165            
Gly Leu Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg
    1170                1175                1180                
Ser Ile Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu
1185                1190                1195                1200
Pro Ser His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys
                1205                1210                1215    
Arg Val Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala
            1220                1225                1230        
Met Ala Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile
        1235                1240                1245            
Glu Ala Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val
    1250                1255                1260                
Ala Ser Ile Asp Leu Ser Arg Lys Thr Val Lys Arg Ile Arg Ile Asn
1265                1270                1275                1280
Phe Val Phe Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala
                1285                1290                1295    
Gly Val Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser
            1300                1305                1310        
Ala Ala Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe
        1315                1320                1325            
Leu Lys Leu Tyr Arg Lys Pro Thr Tyr Glu Ser Tyr Glu Leu Pro Ala
    1330                1335                1340                
Arg Ser Gln Ile Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val
1345                1350                1355                1360
Gly Ile Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp
                1365                1370                1375    
Arg Ile Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp
            1380                1385                1390        
Lys Arg Ser Leu Asn Ser Val Val Thr Ser Glu Pro Asp Lys His Ser
        1395                1400                1405            
Leu Leu Val Gly Asp Phe Arg Glu Asp Asp Asp Thr Ala Leu
    1410                1415                1420        


<210> 9482
<211> 1500
<212> PRT
<213> Homo sapiens

<400> 9482
Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly
 1               5                  10                  15      
Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys
            20                  25                  30          
Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala
        35                  40                  45              
Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu
    50                  55                  60                  
Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro
65                  70                  75                  80  
Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu
                85                  90                  95      
Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly
            100                 105                 110         
Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr
        115                 120                 125             
Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro
    130                 135                 140                 
Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys
145                 150                 155                 160 
Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys
                165                 170                 175     
Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys
            180                 185                 190         
Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn
        195                 200                 205             
Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu
    210                 215                 220                 
Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys
225                 230                 235                 240 
Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys
                245                 250                 255     
Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser
            260                 265                 270         
Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys
        275                 280                 285             
Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr
    290                 295                 300                 
Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys
305                 310                 315                 320 
Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu
                325                 330                 335     
Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu
            340                 345                 350         
Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu
        355                 360                 365             
Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp
    370                 375                 380                 
Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser
385                 390                 395                 400 
Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn
                405                 410                 415     
Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg
            420                 425                 430         
Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn
        435                 440                 445             
Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu
    450                 455                 460                 
Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp
465                 470                 475                 480 
Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly
                485                 490                 495     
Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg
            500                 505                 510         
Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala
        515                 520                 525             
Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu
    530                 535                 540                 
Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp
545                 550                 555                 560 
Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala
                565                 570                 575     
Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile
            580                 585                 590         
Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr
        595                 600                 605             
Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser
    610                 615                 620                 
Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His
625                 630                 635                 640 
Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val
                645                 650                 655     
Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Thr Tyr Met Met
            660                 665                 670         
Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser
        675                 680                 685             
Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln
    690                 695                 700                 
Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys
705                 710                 715                 720 
Val Pro Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala Tyr
                725                 730                 735     
Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu
            740                 745                 750         
Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val Ala
        755                 760                 765             
Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr Pro
    770                 775                 780                 
Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Ile
785                 790                 795                 800 
Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln
                805                 810                 815     
Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu
            820                 825                 830         
Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile
        835                 840                 845             
Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu
    850                 855                 860                 
Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro
865                 870                 875                 880 
Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln
                885                 890                 895     
Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr Thr
            900                 905                 910         
Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala
        915                 920                 925             
Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe
    930                 935                 940                 
Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile Gly
945                 950                 955                 960 
Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg
                965                 970                 975     
Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser
            980                 985                 990         
Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr
        995                 1000                1005            
Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn Gly Ile
    1010                1015                1020                
Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val Lys Val
1025                1030                1035                1040
Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro Val Val
                1045                1050                1055    
Asn Gln Val Lys Val Leu Thr Glu Ser Asn Arg Ile Ser His His Lys
            1060                1065                1070        
Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His Pro Leu
        1075                1080                1085            
Gly Thr Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr Glu Thr
    1090                1095                1100                
Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly Ile Ser
1105                1110                1115                1120
Cys Lys Val Thr Asn Ile Glu Gly Leu Leu His Lys Asn Asn Trp Asn
                1125                1130                1135    
Ile Glu Asp Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile Asp Ala
            1140                1145                1150        
Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met Ile Ile Asp Ala Gln
        1155                1160                1165            
Ile Ser Asn Ala Leu Asn Ala Gln Gln His Lys Val Leu Ile Gly Asn
    1170                1175                1180                
Arg Glu Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp Val Asn
1185                1190                1195                1200
Asp Phe Met Thr Glu His Glu Arg Lys Gly Arg Thr Ala Val Leu Val
                1205                1210                1215    
Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp Thr Val
            1220                1225                1230        
Lys Pro Glu Ala Glu Leu Ala Ile His Ile Leu Lys Ser Met Gly Leu
        1235                1240                1245            
Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg Ser Ile
    1250                1255                1260                
Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu Pro Ser
1265                1270                1275                1280
His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys Arg Val
                1285                1290                1295    
Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala Met Ala
            1300                1305                1310        
Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu Ala
        1315                1320                1325            
Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val Ala Ser
    1330                1335                1340                
Ile Asp Leu Ser Arg Lys Thr Val Lys Arg Ile Arg Ile Asn Phe Val
1345                1350                1355                1360
Phe Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala Gly Val
                1365                1370                1375    
Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser Ala Ala
            1380                1385                1390        
Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe Leu Lys
        1395                1400                1405            
Leu Tyr Arg Lys Pro Thr Tyr Glu Ser Tyr Glu Leu Pro Ala Arg Ser
    1410                1415                1420                
Gln Ile Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val Gly Ile
1425                1430                1435                1440
Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp Arg Ile
                1445                1450                1455    
Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp Lys Arg
            1460                1465                1470        
Ser Leu Asn Ser Val Val Thr Ser Glu Pro Asp Lys His Ser Leu Leu
        1475                1480                1485            
Val Gly Asp Phe Arg Glu Asp Asp Asp Thr Ala Leu
    1490                1495                1500


<210> 9483
<211> 1581
<212> PRT
<213> Homo sapiens

<400> 9483
Met Arg Lys Leu Ser Ile Arg Lys Arg Asp Asn Asn Leu Leu Lys Pro
 1               5                  10                  15      
Ser Ser Ala Ser Ser Leu Gly Ile Ala Val Ser Leu Gly Arg Pro Val
            20                  25                  30          
Leu Ser Arg Ser Ser Ser Gly Thr Val Asn Leu Leu Glu Glu Val Gly
        35                  40                  45              
Leu His Ile Arg Asp Thr Ala Phe Ser Ser Thr Lys Leu Leu Glu Ala
    50                  55                  60                  
Ile Ser Thr Val Ser Ala Gln Val Glu Glu Leu Ala Val His Asn Glu
65                  70                  75                  80  
Cys Tyr Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu
                85                  90                  95      
Gly Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly
            100                 105                 110         
Lys Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn
        115                 120                 125             
Ala Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln
    130                 135                 140                 
Glu Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp
145                 150                 155                 160 
Pro Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser
                165                 170                 175     
Leu Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys
            180                 185                 190         
Gly Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val
        195                 200                 205             
Thr Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val
    210                 215                 220                 
Pro Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala
225                 230                 235                 240 
Cys Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met
                245                 250                 255     
Lys Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly
            260                 265                 270         
Lys Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp
        275                 280                 285             
Asn Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu
    290                 295                 300                 
Glu Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys
305                 310                 315                 320 
Lys Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu
                325                 330                 335     
Lys Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro
            340                 345                 350         
Ser Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His
        355                 360                 365             
Cys Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln
    370                 375                 380                 
Tyr Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val
385                 390                 395                 400 
Lys Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile
                405                 410                 415     
Glu Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val
            420                 425                 430         
Glu Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro
        435                 440                 445             
Leu Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile
    450                 455                 460                 
Asp Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile
465                 470                 475                 480 
Ser Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser
                485                 490                 495     
Asn Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu
            500                 505                 510         
Arg Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr
        515                 520                 525             
Asn Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu
    530                 535                 540                 
Leu Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln
545                 550                 555                 560 
Asp Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr
                565                 570                 575     
Gly Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg
            580                 585                 590         
Arg Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys
        595                 600                 605             
Ala Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala
    610                 615                 620                 
Glu Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala
625                 630                 635                 640 
Asp Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys
                645                 650                 655     
Ala Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly
            660                 665                 670         
Ile Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys
        675                 680                 685             
Tyr Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu
    690                 695                 700                 
Ser Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser
705                 710                 715                 720 
His Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu
                725                 730                 735     
Val Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Thr Tyr Met
            740                 745                 750         
Met Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met
        755                 760                 765             
Ser Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg
    770                 775                 780                 
Gln Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu
785                 790                 795                 800 
Cys Val Pro Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala
                805                 810                 815     
Tyr Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val
            820                 825                 830         
Leu Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val
        835                 840                 845             
Ala Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr
    850                 855                 860                 
Pro Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His
865                 870                 875                 880 
Ile Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu
                885                 890                 895     
Gln Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu
            900                 905                 910         
Leu Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile
        915                 920                 925             
Ile Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile
    930                 935                 940                 
Glu Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met
945                 950                 955                 960 
Pro Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn
                965                 970                 975     
Gln Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr
            980                 985                 990         
Thr Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys
        995                 1000                1005            
Ala Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro
    1010                1015                1020                
Phe Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile
1025                1030                1035                1040
Gly Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn
                1045                1050                1055    
Arg Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala
            1060                1065                1070        
Ser Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala
        1075                1080                1085            
Thr Pro Thr Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn Gly
    1090                1095                1100                
Ile Leu Ile Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val Lys
1105                1110                1115                1120
Val Val Val Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro Val
                1125                1130                1135    
Val Asn Gln Val Lys Val Leu Thr Glu Ser Asn Arg Ile Ser His His
            1140                1145                1150        
Lys Ile Leu Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His Pro
        1155                1160                1165            
Leu Gly Thr Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr Glu
    1170                1175                1180                
Thr Leu Gly Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly Ile
1185                1190                1195                1200
Ser Cys Lys Val Thr Asn Ile Glu Gly Leu Leu His Lys Asn Asn Trp
                1205                1210                1215    
Asn Ile Glu Asp Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile Asp
            1220                1225                1230        
Ala Ser Asn Glu Gln Ser Ser Thr Ser Ser Ser Met Ile Ile Asp Ala
        1235                1240                1245            
Gln Ile Ser Asn Ala Leu Asn Ala Gln Gln His Lys Val Leu Ile Gly
    1250                1255                1260                
Asn Arg Glu Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp Val
1265                1270                1275                1280
Asn Asp Phe Met Thr Glu His Glu Arg Lys Gly Arg Thr Ala Val Leu
                1285                1290                1295    
Val Ala Val Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp Thr
            1300                1305                1310        
Val Lys Pro Glu Ala Glu Leu Ala Ile His Ile Leu Lys Ser Met Gly
        1315                1320                1325            
Leu Glu Val Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg Ser
    1330                1335                1340                
Ile Ala Ser Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu Pro
1345                1350                1355                1360
Ser His Lys Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys Arg
                1365                1370                1375    
Val Ala Met Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala Met
            1380                1385                1390        
Ala Asn Val Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu
        1395                1400                1405            
Ala Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val Ala
    1410                1415                1420                
Ser Ile Asp Leu Ser Arg Lys Thr Val Lys Arg Ile Arg Ile Asn Phe
1425                1430                1435                1440
Val Phe Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala Gly
                1445                1450                1455    
Val Phe Met Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser Ala
            1460                1465                1470        
Ala Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe Leu
        1475                1480                1485            
Lys Leu Tyr Arg Lys Pro Thr Tyr Glu Ser Tyr Glu Leu Pro Ala Arg
    1490                1495                1500                
Ser Gln Ile Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val Gly
1505                1510                1515                1520
Ile Asp Asp Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp Arg
                1525                1530                1535    
Ile Val Asn Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp Lys
            1540                1545                1550        
Arg Ser Leu Asn Ser Val Val Thr Ser Glu Pro Asp Lys His Ser Leu
        1555                1560                1565            
Leu Val Gly Asp Phe Arg Glu Asp Asp Asp Thr Ala Leu
    1570                1575                1580    


<210> 9484
<211> 1514
<212> PRT
<213> Homo sapiens

<400> 9484
Met Arg Lys Leu Ser Ile Arg Lys Arg Asp Asn Asn Leu Leu Lys Asp
 1               5                  10                  15      
Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly Met Thr
            20                  25                  30          
Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys Val Asn
        35                  40                  45              
Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala Thr Ile
    50                  55                  60                  
Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu Ala Ile
65                  70                  75                  80  
Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro Leu Pro
                85                  90                  95      
Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu Thr Leu
            100                 105                 110         
Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly Val Thr
        115                 120                 125             
Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr Ile Ile
    130                 135                 140                 
Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro Glu Leu
145                 150                 155                 160 
Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys Glu Asp
                165                 170                 175     
His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys Val Glu
            180                 185                 190         
Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys Ile Gly
        195                 200                 205             
Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn Gln Glu
    210                 215                 220                 
Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu Met Lys
225                 230                 235                 240 
Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys Gln Pro
                245                 250                 255     
Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys Asn Thr
            260                 265                 270         
Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser Tyr Thr
        275                 280                 285             
Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys Lys Ser
    290                 295                 300                 
Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr Val Ser
305                 310                 315                 320 
Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys Tyr Asn
                325                 330                 335     
Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu Ala Val
            340                 345                 350         
Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu Ser Thr
        355                 360                 365             
Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu Asn Val
    370                 375                 380                 
Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp Gly Met
385                 390                 395                 400 
Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser Lys Lys
                405                 410                 415     
Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn Gly Thr
            420                 425                 430         
Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg Gly Ala
        435                 440                 445             
Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn Glu Pro
    450                 455                 460                 
Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu Thr Ser
465                 470                 475                 480 
Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp Lys Glu
                485                 490                 495     
Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly Met Thr
            500                 505                 510         
Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg Glu Glu
        515                 520                 525             
Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala Glu Val
    530                 535                 540                 
Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu Phe Ile
545                 550                 555                 560 
Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp Glu Gly
                565                 570                 575     
Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala Ser Cys
            580                 585                 590         
Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile Leu Tyr
        595                 600                 605             
Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr Asp Pro
    610                 615                 620                 
Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser Leu Gly
625                 630                 635                 640 
Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His Leu Asp
                645                 650                 655     
His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val Ser Leu
            660                 665                 670         
Phe Phe Cys Ile Pro Val Met Gly Leu Met Thr Tyr Met Met Val Met
        675                 680                 685             
Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser Lys Glu
    690                 695                 700                 
Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln Ile Leu
705                 710                 715                 720 
Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys Val Pro
                725                 730                 735     
Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala Tyr Lys Ala
            740                 745                 750         
Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu Ala Thr
        755                 760                 765             
Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val Ala Met Tyr
    770                 775                 780                 
Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr Pro Pro Met
785                 790                 795                 800 
Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Ile Ala Lys
                805                 810                 815     
Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln Ala Thr
            820                 825                 830         
Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu Ser Glu
        835                 840                 845             
Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile Lys Val
    850                 855                 860                 
Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu Gly His
865                 870                 875                 880 
Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val Ala
                885                 890                 895     
Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln Asn Gly
            900                 905                 910         
Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr Thr Leu Ser
        915                 920                 925             
Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala Pro Ile
    930                 935                 940                 
Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe Ile Val
945                 950                 955                 960 
Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile Gly Phe Leu
                965                 970                 975     
Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg Ser Ile
            980                 985                 990         
Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser Ile Thr
        995                 1000                1005            
Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro Thr
    1010                1015                1020                
Ala Val Met Val Gly Thr Gly Val Gly Ala Gln Asn Gly Ile Leu Ile
1025                1030                1035                1040
Lys Gly Gly Glu Pro Leu Glu Met Ala His Lys Val Lys Val Val Val
                1045                1050                1055    
Phe Asp Lys Thr Gly Thr Ile Thr His Gly Thr Pro Val Val Asn Gln
            1060                1065                1070        
Val Lys Val Leu Thr Glu Ser Asn Arg Ile Ser His His Lys Ile Leu
        1075                1080                1085            
Ala Ile Val Gly Thr Ala Glu Ser Asn Ser Glu His Pro Leu Gly Thr
    1090                1095                1100                
Ala Ile Thr Lys Tyr Cys Lys Gln Glu Leu Asp Thr Glu Thr Leu Gly
1105                1110                1115                1120
Thr Cys Ile Asp Phe Gln Val Val Pro Gly Cys Gly Ile Ser Cys Lys
                1125                1130                1135    
Val Thr Asn Ile Glu Gly Leu Leu His Lys Asn Asn Trp Asn Ile Glu
            1140                1145                1150        
Asp Asn Asn Ile Lys Asn Ala Ser Leu Val Gln Ile Asp Ala Ser Asn
        1155                1160                1165            
Glu Gln Ser Ser Thr Ser Ser Ser Met Ile Ile Asp Ala Gln Ile Ser
    1170                1175                1180                
Asn Ala Leu Asn Ala Gln Gln His Lys Val Leu Ile Gly Asn Arg Glu
1185                1190                1195                1200
Trp Met Ile Arg Asn Gly Leu Val Ile Asn Asn Asp Val Asn Asp Phe
                1205                1210                1215    
Met Thr Glu His Glu Arg Lys Gly Arg Thr Ala Val Leu Val Ala Val
            1220                1225                1230        
Asp Asp Glu Leu Cys Gly Leu Ile Ala Ile Ala Asp Thr Val Lys Pro
        1235                1240                1245            
Glu Ala Glu Leu Ala Ile His Ile Leu Lys Ser Met Gly Leu Glu Val
    1250                1255                1260                
Val Leu Met Thr Gly Asp Asn Ser Lys Thr Ala Arg Ser Ile Ala Ser
1265                1270                1275                1280
Gln Val Gly Ile Thr Lys Val Phe Ala Glu Val Leu Pro Ser His Lys
                1285                1290                1295    
Val Ala Lys Val Lys Gln Leu Gln Glu Glu Gly Lys Arg Val Ala Met
            1300                1305                1310        
Val Gly Asp Gly Ile Asn Asp Ser Pro Ala Leu Ala Met Ala Asn Val
        1315                1320                1325            
Gly Ile Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu Ala Ala Asp
    1330                1335                1340                
Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val Ala Ser Ile Asp
1345                1350                1355                1360
Leu Ser Arg Lys Thr Val Lys Arg Ile Arg Ile Asn Phe Val Phe Ala
                1365                1370                1375    
Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala Gly Val Phe Met
            1380                1385                1390        
Pro Ile Gly Leu Val Leu Gln Pro Trp Met Gly Ser Ala Ala Met Ala
        1395                1400                1405            
Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Phe Leu Lys Leu Tyr
    1410                1415                1420                
Arg Lys Pro Thr Tyr Glu Ser Tyr Glu Leu Pro Ala Arg Ser Gln Ile
1425                1430                1435                1440
Gly Gln Lys Ser Pro Ser Glu Ile Ser Val His Val Gly Ile Asp Asp
                1445                1450                1455    
Thr Ser Arg Asn Ser Pro Lys Leu Gly Leu Leu Asp Arg Ile Val Asn
            1460                1465                1470        
Tyr Ser Arg Ala Ser Ile Asn Ser Leu Leu Ser Asp Lys Arg Ser Leu
        1475                1480                1485            
Asn Ser Val Val Thr Ser Glu Pro Asp Lys His Ser Leu Leu Val Gly
    1490                1495                1500                
Asp Phe Arg Glu Asp Asp Asp Thr Ala Leu
1505                1510                


<210> 9485
<211> 502
<212> PRT
<213> Homo sapiens

<400> 9485
Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Tyr Leu Asp
 1               5                  10                  15      
Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Leu Ile Ala
            20                  25                  30          
Asn Ala Gln Met Glu Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe
        35                  40                  45              
Cys Glu Leu Phe Gly Tyr Ser Arg Val Glu Val Met Gln Gln Pro Cys
    50                  55                  60                  
Thr Cys Asp Phe Leu Thr Gly Pro Asn Thr Pro Ser Ser Ala Val Ser
65                  70                  75                  80  
Arg Leu Ala Gln Ala Leu Leu Gly Ala Glu Glu Cys Lys Val Asp Ile
                85                  90                  95      
Leu Tyr Tyr Arg Lys Asp Ala Ser Ser Phe Arg Cys Leu Val Asp Val
            100                 105                 110         
Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn
        115                 120                 125             
Phe Glu Asp Leu Ala Gln Leu Leu Ala Lys Cys Ser Ser Arg Ser Leu
    130                 135                 140                 
Ser Gln Arg Leu Leu Ser Gln Ser Phe Leu Gly Ser Glu Gly Ser His
145                 150                 155                 160 
Gly Arg Pro Gly Gly Pro Gly Pro Gly Thr Gly Arg Gly Lys Tyr Arg
                165                 170                 175     
Thr Ile Ser Gln Ile Pro Gln Phe Thr Leu Asn Phe Val Glu Phe Asn
            180                 185                 190         
Leu Glu Lys His Arg Ser Ser Ser Thr Thr Glu Ile Glu Ile Ile Ala
        195                 200                 205             
Pro His Lys Val Val Glu Arg Thr Gln Asn Val Thr Glu Lys Val Thr
    210                 215                 220                 
Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln
225                 230                 235                 240 
Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser Pro Phe Lys
                245                 250                 255     
Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Val
            260                 265                 270         
Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Ser Asp Gln Asp Glu Ser
        275                 280                 285             
Arg Arg Gly Ala Cys Ser Tyr Thr Cys Ser Pro Leu Thr Val Val Asp
    290                 295                 300                 
Leu Ile Val Asp Ile Met Phe Val Val Asp Ile Val Ile Asn Phe Arg
305                 310                 315                 320 
Thr Thr Tyr Val Asn Thr Asn Asp Glu Val Val Ser His Pro Arg Arg
                325                 330                 335     
Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala
            340                 345                 350         
Ala Ile Pro Phe Asp Leu Leu Ile Phe Arg Thr Gly Ser Asp Glu Thr
        355                 360                 365             
Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val
    370                 375                 380                 
Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val
385                 390                 395                 400 
Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu Ala
                405                 410                 415     
Cys Ile Trp Tyr Ala Ile Gly Asn Val Glu Arg Pro Tyr Leu Glu His
            420                 425                 430         
Lys Ile Gly Trp Leu Asp Ser Leu Gly Val Gln Leu Gly Lys Arg Tyr
        435                 440                 445             
Asn Gly Ser Asp Pro Ala Ser Gly Pro Ser Val Gln Asp Lys Tyr Val
    450                 455                 460                 
Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly
465                 470                 475                 480 
Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Val Phe Ser Ile Cys Val
                485                 490                 495     
Met Leu Ile Gly Cys Glu
            500         


<210> 9486
<211> 994
<212> PRT
<213> Homo sapiens

<400> 9486
Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Tyr Leu Asp
 1               5                  10                  15      
Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Leu Ile Ala
            20                  25                  30          
Asn Ala Gln Met Glu Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe
        35                  40                  45              
Cys Glu Leu Phe Gly Tyr Ser Arg Val Glu Val Met Gln Gln Pro Cys
    50                  55                  60                  
Thr Cys Asp Phe Leu Thr Gly Pro Asn Thr Pro Ser Ser Ala Val Ser
65                  70                  75                  80  
Arg Leu Ala Gln Ala Leu Leu Gly Ala Glu Glu Cys Lys Val Asp Ile
                85                  90                  95      
Leu Tyr Tyr Arg Lys Asp Ala Ser Ser Phe Arg Cys Leu Val Asp Val
            100                 105                 110         
Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn
        115                 120                 125             
Phe Glu Asp Leu Ala Gln Leu Leu Ala Lys Cys Ser Ser Arg Ser Leu
    130                 135                 140                 
Ser Gln Arg Leu Leu Ser Gln Ser Phe Leu Gly Ser Glu Gly Ser His
145                 150                 155                 160 
Gly Arg Pro Gly Gly Pro Gly Pro Gly Thr Gly Arg Gly Lys Tyr Arg
                165                 170                 175     
Thr Ile Ser Gln Ile Pro Gln Phe Thr Leu Asn Phe Val Glu Phe Asn
            180                 185                 190         
Leu Glu Lys His Arg Ser Ser Ser Thr Thr Glu Ile Glu Ile Ile Ala
        195                 200                 205             
Pro His Lys Val Val Glu Arg Thr Gln Asn Val Thr Glu Lys Val Thr
    210                 215                 220                 
Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln
225                 230                 235                 240 
Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser Pro Phe Lys
                245                 250                 255     
Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Val
            260                 265                 270         
Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Ser Asp Gln Asp Glu Ser
        275                 280                 285             
Arg Arg Gly Ala Cys Ser Tyr Thr Cys Ser Pro Leu Thr Val Val Asp
    290                 295                 300                 
Leu Ile Val Asp Ile Met Phe Val Val Asp Ile Val Ile Asn Phe Arg
305                 310                 315                 320 
Thr Thr Tyr Val Asn Thr Asn Asp Glu Val Val Ser His Pro Arg Arg
                325                 330                 335     
Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala
            340                 345                 350         
Ala Ile Pro Phe Asp Leu Leu Ile Phe Arg Thr Gly Ser Asp Glu Thr
        355                 360                 365             
Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val
    370                 375                 380                 
Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val
385                 390                 395                 400 
Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu Ala
                405                 410                 415     
Cys Ile Trp Tyr Ala Ile Gly Asn Val Glu Arg Pro Tyr Leu Glu His
            420                 425                 430         
Lys Ile Gly Trp Leu Asp Ser Leu Gly Val Gln Leu Gly Lys Arg Tyr
        435                 440                 445             
Asn Gly Ser Asp Pro Ala Ser Gly Pro Ser Val Gln Asp Lys Tyr Val
    450                 455                 460                 
Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly
465                 470                 475                 480 
Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Val Phe Ser Ile Cys Val
                485                 490                 495     
Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser
            500                 505                 510         
Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln
        515                 520                 525             
Met Leu Arg Val Lys Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro
    530                 535                 540                 
Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr
545                 550                 555                 560 
Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu
                565                 570                 575     
Gln Ala Asp Ile Cys Leu His Leu His Arg Ala Leu Leu Gln His Cys
            580                 585                 590         
Pro Ala Phe Ser Gly Ala Gly Lys Gly Cys Leu Arg Ala Leu Ala Val
        595                 600                 605             
Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Leu
    610                 615                 620                 
Gly Asp Val Leu Ser Thr Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu
625                 630                 635                 640 
Ile Leu Arg Asp Asp Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile
                645                 650                 655     
Phe Gly Glu Pro Val Ser Leu His Ala Gln Pro Gly Lys Ser Ser Ala
            660                 665                 670         
Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys Ile Gln Arg Ala
        675                 680                 685             
Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Ala Phe Ala Glu Ser Phe
    690                 695                 700                 
Trp Ser Lys Leu Glu Val Thr Phe Asn Leu Arg Asp Ala Ala Gly Gly
705                 710                 715                 720 
Leu His Ser Ser Pro Arg Gln Ala Pro Gly Ser Gln Asp His Gln Gly
                725                 730                 735     
Phe Phe Leu Ser Asp Asn Gln Ser Gly Ser Pro His Glu Leu Gly Pro
            740                 745                 750         
Gln Phe Pro Ser Lys Gly Tyr Ser Leu Leu Gly Pro Gly Ser Gln Asn
        755                 760                 765             
Ser Met Gly Ala Gly Pro Cys Ala Pro Gly His Pro Asp Ala Ala Pro
    770                 775                 780                 
Pro Leu Ser Ile Ser Asp Ala Ser Gly Leu Trp Pro Glu Leu Leu Gln
785                 790                 795                 800 
Glu Met Pro Pro Arg His Ser Pro Gln Ser Pro Gln Glu Asp Pro Asp
                805                 810                 815     
Cys Trp Pro Leu Lys Leu Gly Ser Arg Leu Glu Gln Leu Gln Ala Gln
            820                 825                 830         
Met Asn Arg Leu Glu Ser Arg Val Ser Ser Asp Leu Ser Arg Ile Leu
        835                 840                 845             
Gln Leu Leu Gln Lys Pro Met Pro Gln Gly His Ala Ser Tyr Ile Leu
    850                 855                 860                 
Glu Ala Pro Ala Ser Asn Asp Leu Ala Leu Val Pro Ile Ala Ser Glu
865                 870                 875                 880 
Thr Thr Ser Pro Gly Pro Arg Leu Pro Gln Gly Phe Leu Pro Pro Ala
                885                 890                 895     
Gln Thr Pro Ser Tyr Gly Asp Leu Asp Asp Cys Ser Pro Lys His Arg
            900                 905                 910         
Asn Ser Ser Pro Arg Met Pro His Leu Ala Val Ala Thr Asp Lys Thr
        915                 920                 925             
Leu Ala Pro Ser Ser Glu Gln Glu Gln Pro Glu Gly Leu Trp Pro Pro
    930                 935                 940                 
Leu Ala Ser Pro Leu His Pro Leu Glu Val Gln Gly Leu Ile Cys Gly
945                 950                 955                 960 
Pro Cys Phe Ser Ser Leu Pro Glu His Leu Gly Ser Val Pro Lys Gln
                965                 970                 975     
Leu Asp Phe Gln Arg His Gly Ser Asp Pro Gly Phe Ala Gly Ser Trp
            980                 985                 990         
Gly His
        


<210> 9487
<211> 3565
<212> PRT
<213> Homo sapiens

<400> 9487
Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu
 1               5                  10                  15      
Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys
            20                  25                  30          
Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe
        35                  40                  45              
Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr
    50                  55                  60                  
Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu
65                  70                  75                  80  
Glu Asn Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly
                85                  90                  95      
Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val
            100                 105                 110         
Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val
        115                 120                 125             
Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr
    130                 135                 140                 
Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg
145                 150                 155                 160 
Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile
                165                 170                 175     
Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly
            180                 185                 190         
Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys
        195                 200                 205             
Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe
    210                 215                 220                 
Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala
225                 230                 235                 240 
Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu
                245                 250                 255     
Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile
            260                 265                 270         
Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn
        275                 280                 285             
Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly
    290                 295                 300                 
Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg
305                 310                 315                 320 
Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val
                325                 330                 335     
Leu Ser Gln Gly Gly Val Ala Leu Val Ser His Met Cys Leu Asp Pro
            340                 345                 350         
Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Ser Arg Val
        355                 360                 365             
Gly Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly
    370                 375                 380                 
Ser Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp
385                 390                 395                 400 
Ser Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu
                405                 410                 415     
Arg Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr
            420                 425                 430         
Glu Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp
        435                 440                 445             
Lys Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr
    450                 455                 460                 
Asp Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser
465                 470                 475                 480 
Val Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser
                485                 490                 495     
Met Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly
            500                 505                 510         
Ser Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys
        515                 520                 525             
Gly Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe
    530                 535                 540                 
Leu His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu
545                 550                 555                 560 
Val Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly
                565                 570                 575     
Asn Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser
            580                 585                 590         
Ser Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn
        595                 600                 605             
Met Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His
    610                 615                 620                 
Leu Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala
625                 630                 635                 640 
Val Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser
                645                 650                 655     
Gly Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg
            660                 665                 670         
Leu Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile
        675                 680                 685             
Thr Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro
    690                 695                 700                 
Ile Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val
705                 710                 715                 720 
Ser Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser
                725                 730                 735     
Ile Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val
            740                 745                 750         
Pro Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly
        755                 760                 765             
Val Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His
    770                 775                 780                 
Cys Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Met Thr
785                 790                 795                 800 
Phe Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg
                805                 810                 815     
Asp Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr
            820                 825                 830         
Gln Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu
        835                 840                 845             
Phe Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr
    850                 855                 860                 
Glu Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro
865                 870                 875                 880 
Val Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val
                885                 890                 895     
Thr Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu
            900                 905                 910         
Val Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp
        915                 920                 925             
Ala Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser
    930                 935                 940                 
Pro Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr
945                 950                 955                 960 
Ile Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe
                965                 970                 975     
His Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser
            980                 985                 990         
Phe Ser Glu Pro Val Ala Arg Leu Thr Gly Ser Val Leu Pro His Thr
        995                 1000                1005            
Ile Lys Ala Gly Leu Phe Gly Asn Phe Thr Ala Gln Leu Arg Phe Ile
    1010                1015                1020                
Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu
1025                1030                1035                1040
Tyr Asp Leu Glu Pro Cys Asp Asp Pro Gly Val Pro Ala Phe Ser Arg
                1045                1050                1055    
Arg Ile Gly Phe His Phe Gly Val Gly Asp Ser Leu Thr Phe Ser Cys
            1060                1065                1070        
Phe Leu Gly Tyr Arg Leu Glu Gly Ala Thr Lys Leu Thr Cys Leu Gly
        1075                1080                1085            
Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys Val Ala Glu
    1090                1095                1100                
Cys Gly Ala Ser Val Lys Gly Asn Glu Gly Thr Leu Leu Ser Pro Asn
1105                1110                1115                1120
Phe Pro Ser Asn Tyr Asp Asn Thr His Glu Cys Ile Tyr Lys Ile Glu
                1125                1130                1135    
Thr Glu Ala Gly Lys Gly Ile His Leu Arg Thr Arg Ser Phe Gln Leu
            1140                1145                1150        
Phe Glu Gly Asp Thr Leu Lys Val Tyr Asp Gly Lys Asp Ser Ser Ser
        1155                1160                1165            
Arg Pro Leu Gly Thr Phe Thr Lys Asn Glu Leu Leu Gly Leu Ile Leu
    1170                1175                1180                
Asn Ser Thr Ser Asn His Leu Trp Leu Glu Phe Asn Thr Asn Gly Ser
1185                1190                1195                1200
Asp Thr Asp Gln Gly Phe Gln Leu Thr Tyr Thr Ser Phe Asp Leu Val
                1205                1210                1215    
Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr Gly Tyr Arg Ile Arg Asp
            1220                1225                1230        
Glu Gly His Phe Thr Asp Thr Val Val Leu Tyr Ser Cys Asn Pro Gly
        1235                1240                1245            
Tyr Ala Met His Gly Ser Asn Thr Leu Thr Cys Leu Ser Gly Asp Arg
    1250                1255                1260                
Arg Val Trp Asp Lys Pro Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly
1265                1270                1275                1280
Gln Ile His Ala Ala Thr Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro
                1285                1290                1295    
Ala Pro Tyr Asp Asn Asn Leu His Cys Thr Trp Ile Ile Glu Ala Asp
            1300                1305                1310        
Pro Gly Lys Thr Ile Ser Leu His Phe Ile Val Phe Asp Thr Glu Met
        1315                1320                1325            
Ala His Asp Ile Leu Lys Val Trp Asp Gly Pro Val Asp Ser Asp Ile
    1330                1335                1340                
Leu Leu Lys Glu Trp Ser Gly Ser Ala Leu Pro Glu Asp Ile His Ser
1345                1350                1355                1360
Thr Phe Asn Ser Leu Thr Leu Gln Phe Asp Ser Asp Phe Phe Ile Ser
                1365                1370                1375    
Lys Ser Gly Phe Ser Ile Gln Phe Ser Thr Ser Ile Ala Ala Thr Cys
            1380                1385                1390        
Asn Asp Pro Gly Met Pro Gln Asn Gly Thr Arg Tyr Gly Asp Ser Arg
        1395                1400                1405            
Glu Ala Gly Asp Thr Val Thr Phe Gln Cys Asp Pro Gly Tyr Gln Leu
    1410                1415                1420                
Gln Gly Gln Ala Lys Ile Thr Cys Val Gln Leu Asn Asn Arg Phe Phe
1425                1430                1435                1440
Trp Gln Pro Asp Pro Pro Thr Cys Ile Ala Ala Cys Gly Gly Asn Leu
                1445                1450                1455    
Thr Gly Pro Ala Gly Val Ile Leu Ser Pro Asn Tyr Pro Gln Pro Tyr
            1460                1465                1470        
Pro Pro Gly Lys Glu Cys Asp Trp Arg Val Lys Val Asn Pro Asp Phe
        1475                1480                1485            
Val Ile Ala Leu Ile Phe Lys Ser Phe Asn Met Glu Pro Ser Tyr Asp
    1490                1495                1500                
Phe Leu His Ile Tyr Glu Gly Glu Asp Ser Asn Ser Pro Leu Ile Gly
1505                1510                1515                1520
Ser Tyr Gln Gly Ser Gln Ala Pro Glu Arg Ile Glu Ser Ser Gly Asn
                1525                1530                1535    
Ser Leu Phe Leu Ala Phe Arg Ser Asp Ala Ser Val Gly Leu Ser Gly
            1540                1545                1550        
Phe Ala Ile Glu Phe Lys Glu Lys Pro Arg Glu Ala Cys Phe Asp Pro
        1555                1560                1565            
Gly Asn Ile Met Asn Gly Thr Arg Val Gly Thr Asp Phe Lys Leu Gly
    1570                1575                1580                
Ser Thr Ile Thr Tyr Gln Cys Asp Ser Gly Tyr Lys Ile Leu Asp Pro
1585                1590                1595                1600
Ser Ser Ile Thr Cys Val Ile Gly Ala Asp Gly Lys Pro Ser Trp Asp
                1605                1610                1615    
Gln Val Leu Pro Ser Cys Asn Ala Pro Cys Gly Gly Gln Tyr Thr Gly
            1620                1625                1630        
Ser Glu Gly Val Val Leu Ser Pro Asn Tyr Pro His Asn Tyr Thr Ala
        1635                1640                1645            
Gly Gln Ile Cys Leu Tyr Ser Ile Thr Val Pro Lys Glu Phe Val Val
    1650                1655                1660                
Phe Gly Gln Phe Ala Tyr Phe Gln Thr Ala Leu Asn Asp Leu Ala Glu
1665                1670                1675                1680
Leu Phe Asp Gly Thr His Ala Gln Ala Arg Leu Leu Ser Ser Leu Ser
                1685                1690                1695    
Gly Ser His Ser Gly Glu Thr Leu Pro Leu Ala Thr Ser Asn Gln Ile
            1700                1705                1710        
Leu Leu Arg Phe Ser Ala Lys Ser Gly Ala Ser Ala Arg Gly Phe His
        1715                1720                1725            
Phe Val Tyr Gln Ala Val Pro Arg Thr Ser Asp Thr Gln Cys Ser Ser
    1730                1735                1740                
Val Pro Glu Pro Arg Tyr Gly Arg Arg Ile Gly Ser Glu Phe Ser Ala
1745                1750                1755                1760
Gly Ser Ile Val Arg Phe Glu Cys Asn Pro Gly Tyr Leu Leu Gln Gly
                1765                1770                1775    
Ser Thr Ala Leu His Cys Gln Ser Val Pro Asn Ala Leu Ala Gln Trp
            1780                1785                1790        
Asn Asp Thr Ile Pro Ser Cys Val Val Pro Cys Ser Gly Asn Phe Thr
        1795                1800                1805            
Gln Arg Arg Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu Pro Tyr Gly
    1810                1815                1820                
Asn Asn Leu Asn Cys Ile Trp Lys Ile Ile Val Thr Glu Gly Ser Gly
1825                1830                1835                1840
Ile Gln Ile Gln Val Ile Ser Phe Ala Thr Glu Gln Asn Trp Asp Ser
                1845                1850                1855    
Leu Glu Ile His Asp Gly Gly Asp Val Thr Ala Pro Arg Leu Gly Ser
            1860                1865                1870        
Phe Ser Gly Thr Thr Val Pro Ala Leu Leu Asn Ser Thr Ser Asn Gln
        1875                1880                1885            
Leu Tyr Leu His Phe Gln Ser Asp Ile Ser Val Ala Ala Ala Gly Phe
    1890                1895                1900                
His Leu Glu Tyr Lys Thr Val Gly Leu Ala Ala Cys Gln Glu Pro Ala
1905                1910                1915                1920
Leu Pro Ser Asn Ser Ile Lys Ile Gly Asp Arg Tyr Met Val Asn Asp
                1925                1930                1935    
Val Leu Ser Phe Gln Cys Glu Pro Gly Tyr Thr Leu Gln Gly Arg Ser
            1940                1945                1950        
His Ile Ser Cys Met Pro Gly Thr Val Arg Arg Trp Asn Tyr Pro Ser
        1955                1960                1965            
Pro Leu Cys Ile Ala Thr Cys Gly Gly Thr Leu Ser Thr Leu Gly Gly
    1970                1975                1980                
Val Ile Leu Ser Pro Gly Phe Pro Gly Ser Tyr Pro Asn Asn Leu Asp
1985                1990                1995                2000
Cys Thr Trp Arg Ile Ser Leu Pro Ile Gly Tyr Gly Ala His Ile Gln
                2005                2010                2015    
Phe Leu Asn Phe Ser Thr Glu Ala Asn His Asp Phe Leu Glu Ile Gln
            2020                2025                2030        
Asn Gly Pro Tyr His Thr Ser Pro Met Ile Gly Gln Phe Ser Gly Thr
        2035                2040                2045            
Asp Leu Pro Ala Ala Leu Leu Ser Thr Thr His Glu Thr Leu Ile His
    2050                2055                2060                
Phe Tyr Ser Asp His Ser Gln Asn Arg Gln Gly Phe Lys Leu Ala Tyr
2065                2070                2075                2080
Gln Ala Tyr Glu Leu Gln Asn Cys Pro Asp Pro Pro Pro Phe Gln Asn
                2085                2090                2095    
Gly Tyr Met Ile Asn Ser Asp Tyr Ser Val Gly Gln Ser Val Ser Phe
            2100                2105                2110        
Glu Cys Tyr Pro Gly Tyr Ile Leu Ile Gly His Pro Val Leu Thr Cys
        2115                2120                2125            
Gln His Gly Ile Asn Arg Asn Trp Asn Tyr Pro Phe Pro Arg Cys Asp
    2130                2135                2140                
Ala Pro Cys Gly Tyr Asn Val Thr Ser Gln Asn Gly Thr Ile Tyr Ser
2145                2150                2155                2160
Pro Gly Phe Pro Asp Glu Tyr Pro Ile Leu Lys Asp Cys Ile Trp Leu
                2165                2170                2175    
Ile Thr Val Pro Pro Gly His Gly Val Tyr Ile Asn Phe Thr Leu Leu
            2180                2185                2190        
Gln Thr Glu Ala Val Asn Asp Tyr Ile Ala Val Trp Asp Gly Pro Asp
        2195                2200                2205            
Gln Asn Ser Pro Gln Leu Gly Val Phe Ser Gly Asn Thr Ala Leu Glu
    2210                2215                2220                
Thr Ala Tyr Ser Ser Thr Asn Gln Val Leu Leu Lys Phe His Ser Asp
2225                2230                2235                2240
Phe Ser Asn Gly Gly Phe Phe Val Leu Asn Phe His Ala Phe Gln Leu
                2245                2250                2255    
Lys Lys Cys Gln Pro Pro Pro Ala Val Pro Gln Ala Glu Met Leu Thr
            2260                2265                2270        
Glu Asp Asp Asp Phe Glu Ile Gly Asp Phe Val Lys Tyr Gln Cys His
        2275                2280                2285            
Pro Gly Tyr Thr Leu Val Gly Thr Asp Ile Leu Thr Cys Lys Leu Ser
    2290                2295                2300                
Ser Gln Leu Gln Phe Glu Gly Ser Leu Pro Thr Cys Glu Ala Gln Cys
2305                2310                2315                2320
Pro Ala Asn Glu Val Arg Thr Gly Ser Ser Gly Val Ile Leu Ser Pro
                2325                2330                2335    
Gly Tyr Pro Gly Asn Tyr Phe Asn Ser Gln Thr Cys Ser Trp Ser Ile
            2340                2345                2350        
Lys Val Glu Pro Asn Tyr Asn Ile Thr Ile Phe Val Asp Thr Phe Gln
        2355                2360                2365            
Ser Glu Lys Gln Phe Asp Ala Leu Glu Val Phe Asp Gly Ser Ser Gly
    2370                2375                2380                
Gln Ser Pro Leu Leu Val Val Leu Ser Gly Asn His Thr Glu Gln Ser
2385                2390                2395                2400
Asn Phe Thr Ser Arg Ser Asn Gln Leu Tyr Leu Arg Trp Ser Thr Asp
                2405                2410                2415    
His Ala Thr Ser Lys Lys Gly Phe Lys Ile Arg Tyr Ala Ala Pro Tyr
            2420                2425                2430        
Cys Ser Leu Thr His Pro Leu Lys Asn Gly Gly Ile Leu Asn Arg Thr
        2435                2440                2445            
Ala Gly Ala Val Gly Ser Lys Val His Tyr Phe Cys Lys Pro Gly Tyr
    2450                2455                2460                
Arg Met Val Gly His Ser Asn Ala Thr Cys Arg Arg Asn Pro Leu Gly
2465                2470                2475                2480
Met Tyr Gln Trp Asp Ser Leu Thr Pro Leu Cys Gln Ala Val Ser Cys
                2485                2490                2495    
Gly Ile Pro Glu Ser Pro Gly Asn Gly Ser Phe Thr Gly Asn Glu Phe
            2500                2505                2510        
Thr Leu Asp Ser Lys Val Val Tyr Glu Cys His Glu Gly Phe Lys Leu
        2515                2520                2525            
Glu Ser Ser Gln Gln Ala Thr Ala Val Cys Gln Glu Asp Gly Leu Trp
    2530                2535                2540                
Ser Asn Lys Gly Lys Pro Pro Met Cys Lys Pro Val Ala Cys Pro Ser
2545                2550                2555                2560
Ile Glu Ala Gln Leu Ser Glu His Val Ile Trp Arg Leu Val Ser Gly
                2565                2570                2575    
Ser Leu Asn Glu Tyr Gly Ala Gln Val Leu Leu Ser Cys Ser Pro Gly
            2580                2585                2590        
Tyr Tyr Leu Glu Gly Trp Arg Leu Leu Arg Cys Gln Ala Asn Gly Thr
        2595                2600                2605            
Trp Asn Ile Gly Asp Glu Arg Pro Ser Cys Arg Val Ile Ser Cys Gly
    2610                2615                2620                
Ser Leu Ser Phe Pro Pro Asn Gly Asn Lys Ile Gly Thr Leu Thr Val
2625                2630                2635                2640
Tyr Gly Ala Thr Ala Ile Phe Thr Cys Asn Thr Gly Tyr Thr Leu Val
                2645                2650                2655    
Gly Ser His Val Arg Glu Cys Leu Ala Asn Gly Leu Trp Ser Gly Ser
            2660                2665                2670        
Glu Thr Arg Cys Leu Ala Gly His Cys Gly Ser Pro Asp Pro Ile Val
        2675                2680                2685            
Asn Gly His Ile Ser Gly Asp Gly Phe Ser Tyr Arg Asp Thr Val Val
    2690                2695                2700                
Tyr Gln Cys Asn Pro Gly Phe Arg Leu Val Gly Thr Ser Val Arg Ile
2705                2710                2715                2720
Cys Leu Gln Asp His Lys Trp Ser Gly Gln Thr Pro Val Cys Val Pro
                2725                2730                2735    
Ile Thr Cys Gly His Pro Gly Asn Pro Ala His Gly Phe Thr Asn Gly
            2740                2745                2750        
Ser Glu Phe Asn Leu Asn Asp Val Val Asn Phe Thr Cys Asn Thr Gly
        2755                2760                2765            
Tyr Leu Leu Gln Gly Val Ser Arg Ala Gln Cys Arg Ser Asn Gly Gln
    2770                2775                2780                
Trp Ser Ser Pro Leu Pro Thr Cys Arg Val Val Asn Cys Ser Asp Pro
2785                2790                2795                2800
Gly Phe Val Glu Asn Ala Ile Arg His Gly Gln Gln Asn Phe Pro Glu
                2805                2810                2815    
Ser Phe Glu Tyr Gly Met Ser Ile Leu Tyr His Cys Lys Lys Gly Phe
            2820                2825                2830        
His Leu Leu Gly Ser Ser Ala Leu Thr Cys Met Ala Asn Gly Leu Trp
        2835                2840                2845            
Asp Arg Ser Leu Pro Lys Cys Leu Ala Ile Ser Cys Gly His Pro Gly
    2850                2855                2860                
Val Pro Ala Asn Ala Val Leu Thr Gly Glu Leu Phe Thr Tyr Gly Ala
2865                2870                2875                2880
Val Val His Tyr Ser Cys Arg Gly Ser Glu Ser Leu Ile Gly Asn Asp
                2885                2890                2895    
Thr Arg Val Cys Gln Glu Asp Ser His Trp Ser Gly Ala Leu Pro His
            2900                2905                2910        
Cys Thr Gly Asn Asn Pro Gly Phe Cys Gly Asp Pro Gly Thr Pro Ala
        2915                2920                2925            
His Gly Ser Arg Leu Gly Asp Asp Phe Lys Thr Lys Ser Leu Leu Arg
    2930                2935                2940                
Phe Ser Cys Glu Met Gly His Gln Leu Arg Gly Ser Pro Glu Arg Thr
2945                2950                2955                2960
Cys Leu Leu Asn Gly Ser Trp Ser Gly Leu Gln Pro Val Cys Glu Ala
                2965                2970                2975    
Val Ser Cys Gly Asn Pro Gly Thr Pro Thr Asn Gly Met Ile Val Ser
            2980                2985                2990        
Ser Asp Gly Ile Leu Phe Ser Ser Ser Val Ile Tyr Ala Cys Trp Glu
        2995                3000                3005            
Gly Tyr Lys Thr Ser Gly Leu Met Thr Arg His Cys Thr Ala Asn Gly
    3010                3015                3020                
Thr Trp Thr Gly Thr Ala Pro Asp Cys Thr Ile Ile Ser Cys Gly Asp
3025                3030                3035                3040
Pro Gly Thr Leu Ala Asn Gly Ile Gln Phe Gly Thr Asp Phe Thr Phe
                3045                3050                3055    
Asn Lys Thr Val Ser Tyr Gln Cys Asn Pro Gly Tyr Val Met Glu Ala
            3060                3065                3070        
Val Thr Ser Ala Thr Ile Arg Cys Thr Lys Asp Gly Arg Trp Asn Pro
        3075                3080                3085            
Ser Lys Pro Val Cys Lys Ala Val Leu Cys Pro Gln Pro Pro Pro Val
    3090                3095                3100                
Gln Asn Gly Thr Val Glu Gly Ser Asp Phe Arg Trp Gly Ser Ser Ile
3105                3110                3115                3120
Ser Tyr Ser Cys Met Asp Gly Tyr Gln Leu Ser His Ser Ala Ile Leu
                3125                3130                3135    
Ser Cys Glu Gly Arg Gly Val Trp Lys Gly Glu Ile Pro Gln Cys Leu
            3140                3145                3150        
Pro Val Phe Cys Gly Asp Pro Gly Ile Pro Ala Glu Gly Arg Leu Ser
        3155                3160                3165            
Gly Lys Ser Phe Thr Tyr Lys Ser Glu Val Phe Phe Gln Cys Lys Ser
    3170                3175                3180                
Pro Phe Ile Leu Val Gly Ser Ser Arg Arg Val Cys Gln Ala Asp Gly
3185                3190                3195                3200
Thr Trp Ser Gly Ile Gln Pro Thr Cys Ile Asp Pro Ala His Asn Thr
                3205                3210                3215    
Cys Pro Asp Pro Gly Thr Pro His Phe Gly Ile Gln Asn Ser Ser Arg
            3220                3225                3230        
Gly Tyr Glu Val Gly Ser Thr Val Phe Phe Arg Cys Arg Lys Gly Tyr
        3235                3240                3245            
His Ile Gln Gly Ser Thr Thr Arg Thr Cys Leu Ala Asn Leu Thr Trp
    3250                3255                3260                
Ser Gly Ile Gln Thr Glu Cys Ile Pro His Ala Cys Arg Gln Pro Glu
3265                3270                3275                3280
Thr Pro Ala His Ala Asp Val Arg Ala Ile Asp Leu Pro Thr Phe Gly
                3285                3290                3295    
Tyr Thr Leu Val Tyr Thr Cys His Pro Gly Phe Phe Leu Ala Gly Gly
            3300                3305                3310        
Ser Glu His Arg Thr Cys Lys Ala Asp Met Lys Trp Thr Gly Lys Ser
        3315                3320                3325            
Pro Val Cys Lys Ser Lys Gly Val Arg Glu Val Asn Glu Thr Val Thr
    3330                3335                3340                
Lys Thr Pro Val Pro Ser Asp Val Phe Phe Val Asn Ser Leu Trp Lys
3345                3350                3355                3360
Gly Tyr Tyr Glu Tyr Leu Gly Lys Arg Gln Pro Ala Thr Leu Thr Val
                3365                3370                3375    
Asp Trp Phe Asn Ala Thr Ser Ser Lys Val Asn Ala Thr Phe Ser Glu
            3380                3385                3390        
Ala Ser Pro Val Glu Leu Lys Leu Thr Gly Ile Tyr Lys Lys Glu Glu
        3395                3400                3405            
Ala His Leu Leu Leu Lys Ala Phe Gln Ile Lys Gly Gln Ala Asp Ile
    3410                3415                3420                
Phe Val Ser Lys Phe Glu Asn Asp Asn Trp Gly Leu Asp Gly Tyr Val
3425                3430                3435                3440
Ser Ser Gly Leu Glu Arg Gly Gly Phe Thr Phe Gln Gly Asp Ile His
                3445                3450                3455    
Gly Lys Asp Phe Gly Lys Phe Lys Leu Glu Arg Gln Asp Pro Leu Asn
            3460                3465                3470        
Pro Asp Gln Asp Ser Ser Ser His Tyr His Gly Thr Ser Ser Gly Ser
        3475                3480                3485            
Val Ala Ala Ala Ile Leu Val Pro Phe Phe Ala Leu Ile Leu Ser Gly
    3490                3495                3500                
Phe Ala Phe Tyr Leu Tyr Lys His Arg Thr Arg Pro Lys Val Gln Tyr
3505                3510                3515                3520
Asn Gly Tyr Ala Gly His Glu Asn Ser Asn Gly Gln Ala Ser Phe Glu
                3525                3530                3535    
Asn Pro Met Tyr Asp Thr Asn Leu Lys Pro Thr Glu Ala Lys Ala Val
            3540                3545                3550        
Arg Phe Asp Thr Thr Leu Asn Thr Val Cys Thr Val Val
        3555                3560                3565


<210> 9488
<211> 3388
<212> PRT
<213> Homo sapiens

<400> 9488
Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu
 1               5                  10                  15      
Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys
            20                  25                  30          
Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe
        35                  40                  45              
Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr
    50                  55                  60                  
Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu
65                  70                  75                  80  
Glu Asn Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly
                85                  90                  95      
Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val
            100                 105                 110         
Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val
        115                 120                 125             
Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr
    130                 135                 140                 
Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg
145                 150                 155                 160 
Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile
                165                 170                 175     
Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly
            180                 185                 190         
Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys
        195                 200                 205             
Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe
    210                 215                 220                 
Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala
225                 230                 235                 240 
Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu
                245                 250                 255     
Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile
            260                 265                 270         
Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn
        275                 280                 285             
Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly
    290                 295                 300                 
Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg
305                 310                 315                 320 
Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val
                325                 330                 335     
Leu Ser Gln Gly Gly Val Ala Leu Val Ser His Met Cys Leu Asp Pro
            340                 345                 350         
Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Ser Arg Val
        355                 360                 365             
Gly Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly
    370                 375                 380                 
Ser Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp
385                 390                 395                 400 
Ser Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu
                405                 410                 415     
Arg Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr
            420                 425                 430         
Glu Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp
        435                 440                 445             
Lys Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr
    450                 455                 460                 
Asp Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser
465                 470                 475                 480 
Val Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser
                485                 490                 495     
Met Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly
            500                 505                 510         
Ser Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys
        515                 520                 525             
Gly Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe
    530                 535                 540                 
Leu His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu
545                 550                 555                 560 
Val Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly
                565                 570                 575     
Asn Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser
            580                 585                 590         
Ser Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn
        595                 600                 605             
Met Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His
    610                 615                 620                 
Leu Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala
625                 630                 635                 640 
Val Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser
                645                 650                 655     
Gly Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg
            660                 665                 670         
Leu Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile
        675                 680                 685             
Thr Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro
    690                 695                 700                 
Ile Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val
705                 710                 715                 720 
Ser Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser
                725                 730                 735     
Ile Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val
            740                 745                 750         
Pro Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly
        755                 760                 765             
Val Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His
    770                 775                 780                 
Cys Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Met Thr
785                 790                 795                 800 
Phe Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg
                805                 810                 815     
Asp Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr
            820                 825                 830         
Gln Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu
        835                 840                 845             
Phe Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr
    850                 855                 860                 
Glu Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro
865                 870                 875                 880 
Val Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val
                885                 890                 895     
Thr Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu
            900                 905                 910         
Val Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp
        915                 920                 925             
Ala Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser
    930                 935                 940                 
Pro Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr
945                 950                 955                 960 
Ile Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe
                965                 970                 975     
His Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser
            980                 985                 990         
Phe Ser Glu Pro Val Ala Arg Leu Thr Gly Ser Val Leu Pro His Thr
        995                 1000                1005            
Ile Lys Ala Gly Leu Phe Gly Asn Phe Thr Ala Gln Leu Arg Phe Ile
    1010                1015                1020                
Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu
1025                1030                1035                1040
Tyr Asp Leu Glu Pro Cys Asp Asp Pro Gly Val Pro Ala Phe Ser Arg
                1045                1050                1055    
Arg Ile Gly Phe His Phe Gly Val Gly Asp Ser Leu Thr Phe Ser Cys
            1060                1065                1070        
Phe Leu Gly Tyr Arg Leu Glu Gly Ala Thr Lys Leu Thr Cys Leu Gly
        1075                1080                1085            
Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys Val Ala Glu
    1090                1095                1100                
Cys Gly Ala Ser Val Lys Gly Asn Glu Gly Thr Leu Leu Ser Pro Asn
1105                1110                1115                1120
Phe Pro Ser Asn Tyr Asp Asn Thr His Glu Cys Ile Tyr Lys Ile Glu
                1125                1130                1135    
Thr Glu Ala Gly Lys Gly Ile His Leu Arg Thr Arg Ser Phe Gln Leu
            1140                1145                1150        
Phe Glu Gly Asp Thr Leu Lys Val Tyr Asp Gly Lys Asp Ser Ser Ser
        1155                1160                1165            
Arg Pro Leu Gly Thr Phe Thr Lys Asn Glu Leu Leu Gly Leu Ile Leu
    1170                1175                1180                
Asn Ser Thr Ser Asn His Leu Trp Leu Glu Phe Asn Thr Asn Gly Ser
1185                1190                1195                1200
Asp Thr Asp Gln Gly Phe Gln Leu Thr Tyr Thr Ser Phe Asp Leu Val
                1205                1210                1215    
Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr Gly Tyr Arg Ile Arg Asp
            1220                1225                1230        
Glu Gly His Phe Thr Asp Thr Val Val Leu Tyr Ser Cys Asn Pro Gly
        1235                1240                1245            
Tyr Ala Met His Gly Ser Asn Thr Leu Thr Cys Leu Ser Gly Asp Arg
    1250                1255                1260                
Arg Val Trp Asp Lys Pro Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly
1265                1270                1275                1280
Gln Ile His Ala Ala Thr Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro
                1285                1290                1295    
Ala Pro Tyr Asp Asn Asn Leu His Cys Thr Trp Ile Ile Glu Ala Asp
            1300                1305                1310        
Pro Gly Lys Thr Ile Ser Leu His Phe Ile Val Phe Asp Thr Glu Met
        1315                1320                1325            
Ala His Asp Ile Leu Lys Val Trp Asp Gly Pro Val Asp Ser Asp Ile
    1330                1335                1340                
Leu Leu Lys Glu Trp Ser Gly Ser Ala Leu Pro Glu Asp Ile His Ser
1345                1350                1355                1360
Thr Phe Asn Ser Leu Thr Leu Gln Phe Asp Ser Asp Phe Phe Ile Ser
                1365                1370                1375    
Lys Ser Gly Phe Ser Ile Gln Phe Ser Thr Ser Ile Ala Ala Thr Cys
            1380                1385                1390        
Asn Asp Pro Gly Met Pro Gln Asn Gly Thr Arg Tyr Gly Asp Ser Arg
        1395                1400                1405            
Glu Ala Gly Asp Thr Val Thr Phe Gln Cys Asp Pro Gly Tyr Gln Leu
    1410                1415                1420                
Gln Gly Gln Ala Lys Ile Thr Cys Val Gln Leu Asn Asn Arg Phe Phe
1425                1430                1435                1440
Trp Gln Pro Asp Pro Pro Thr Cys Ile Ala Ala Cys Gly Gly Asn Leu
                1445                1450                1455    
Thr Gly Pro Ala Gly Val Ile Leu Ser Pro Asn Tyr Pro Gln Pro Tyr
            1460                1465                1470        
Pro Pro Gly Lys Glu Cys Asp Trp Arg Val Lys Val Asn Pro Asp Phe
        1475                1480                1485            
Val Ile Ala Leu Ile Phe Lys Ser Phe Asn Met Glu Pro Ser Tyr Asp
    1490                1495                1500                
Phe Leu His Ile Tyr Glu Gly Glu Asp Ser Asn Ser Pro Leu Ile Gly
1505                1510                1515                1520
Ser Tyr Gln Gly Ser Gln Ala Pro Glu Arg Ile Glu Ser Ser Gly Asn
                1525                1530                1535    
Ser Leu Phe Leu Ala Phe Arg Ser Asp Ala Ser Val Gly Leu Ser Gly
            1540                1545                1550        
Phe Ala Ile Glu Phe Lys Glu Lys Pro Arg Glu Ala Cys Phe Asp Pro
        1555                1560                1565            
Gly Asn Ile Met Asn Gly Thr Arg Val Gly Thr Asp Phe Lys Leu Gly
    1570                1575                1580                
Ser Thr Ile Thr Tyr Gln Cys Asp Ser Gly Tyr Lys Ile Leu Asp Pro
1585                1590                1595                1600
Ser Ser Ile Thr Cys Val Ile Gly Ala Asp Gly Lys Pro Ser Trp Asp
                1605                1610                1615    
Gln Val Leu Pro Ser Cys Asn Ala Pro Cys Gly Gly Gln Tyr Thr Gly
            1620                1625                1630        
Ser Glu Gly Val Val Leu Ser Pro Asn Tyr Pro His Asn Tyr Thr Ala
        1635                1640                1645            
Gly Gln Ile Cys Leu Tyr Ser Ile Thr Val Pro Lys Glu Phe Val Val
    1650                1655                1660                
Phe Gly Gln Phe Ala Tyr Phe Gln Thr Ala Leu Asn Asp Leu Ala Glu
1665                1670                1675                1680
Leu Phe Asp Gly Thr His Ala Gln Ala Arg Leu Leu Ser Ser Leu Ser
                1685                1690                1695    
Gly Ser His Ser Gly Glu Thr Leu Pro Leu Ala Thr Ser Asn Gln Ile
            1700                1705                1710        
Leu Leu Arg Phe Ser Ala Lys Ser Gly Ala Ser Ala Arg Gly Phe His
        1715                1720                1725            
Phe Val Tyr Gln Ala Val Pro Arg Thr Ser Asp Thr Gln Cys Ser Ser
    1730                1735                1740                
Val Pro Glu Pro Arg Tyr Gly Arg Arg Ile Gly Ser Glu Phe Ser Ala
1745                1750                1755                1760
Gly Ser Ile Val Arg Phe Glu Cys Asn Pro Gly Tyr Leu Leu Gln Gly
                1765                1770                1775    
Ser Thr Ala Leu His Cys Gln Ser Val Pro Asn Ala Leu Ala Gln Trp
            1780                1785                1790        
Asn Asp Thr Ile Pro Ser Cys Val Val Pro Cys Ser Gly Asn Phe Thr
        1795                1800                1805            
Gln Arg Arg Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu Pro Tyr Gly
    1810                1815                1820                
Asn Asn Leu Asn Cys Ile Trp Lys Ile Ile Val Thr Glu Gly Ser Gly
1825                1830                1835                1840
Ile Gln Ile Gln Val Ile Ser Phe Ala Thr Glu Gln Asn Trp Asp Ser
                1845                1850                1855    
Leu Glu Ile His Asp Gly Gly Asp Val Thr Ala Pro Arg Leu Gly Ser
            1860                1865                1870        
Phe Ser Gly Thr Thr Val Pro Ala Leu Leu Asn Ser Thr Ser Asn Gln
        1875                1880                1885            
Leu Tyr Leu His Phe Gln Ser Asp Ile Ser Val Ala Ala Ala Gly Phe
    1890                1895                1900                
His Leu Glu Tyr Lys Thr Val Gly Leu Ala Ala Cys Gln Glu Pro Ala
1905                1910                1915                1920
Leu Pro Ser Asn Ser Ile Lys Ile Gly Asp Arg Tyr Met Val Asn Asp
                1925                1930                1935    
Val Leu Ser Phe Gln Cys Glu Pro Gly Tyr Thr Leu Gln Gly Arg Ser
            1940                1945                1950        
His Ile Ser Cys Met Pro Gly Thr Val Arg Arg Trp Asn Tyr Pro Ser
        1955                1960                1965            
Pro Leu Cys Ile Ala Thr Cys Gly Gly Thr Leu Ser Thr Leu Gly Gly
    1970                1975                1980                
Val Ile Leu Ser Pro Gly Phe Pro Gly Ser Tyr Pro Asn Asn Leu Asp
1985                1990                1995                2000
Cys Thr Trp Arg Ile Ser Leu Pro Ile Gly Tyr Gly Ala His Ile Gln
                2005                2010                2015    
Phe Leu Asn Phe Ser Thr Glu Ala Asn His Asp Phe Leu Glu Ile Gln
            2020                2025                2030        
Asn Gly Pro Tyr His Thr Ser Pro Met Ile Gly Gln Phe Ser Gly Thr
        2035                2040                2045            
Asp Leu Pro Ala Ala Leu Leu Ser Thr Thr His Glu Thr Leu Ile His
    2050                2055                2060                
Phe Tyr Ser Asp His Ser Gln Asn Arg Gln Gly Phe Lys Leu Ala Tyr
2065                2070                2075                2080
Gln Ala Tyr Glu Leu Gln Asn Cys Pro Asp Pro Pro Pro Phe Gln Asn
                2085                2090                2095    
Gly Tyr Met Ile Asn Ser Asp Tyr Ser Val Gly Gln Ser Val Ser Phe
            2100                2105                2110        
Glu Cys Tyr Pro Gly Tyr Ile Leu Ile Gly His Pro Val Leu Thr Cys
        2115                2120                2125            
Gln His Gly Ile Asn Arg Asn Trp Asn Tyr Pro Phe Pro Arg Cys Asp
    2130                2135                2140                
Ala Pro Cys Gly Tyr Asn Val Thr Ser Gln Asn Gly Thr Ile Tyr Ser
2145                2150                2155                2160
Pro Gly Phe Pro Asp Glu Tyr Pro Ile Leu Lys Asp Cys Ile Trp Leu
                2165                2170                2175    
Ile Thr Val Pro Pro Gly His Gly Val Tyr Ile Asn Phe Thr Leu Leu
            2180                2185                2190        
Gln Thr Glu Ala Val Asn Asp Tyr Ile Ala Val Trp Asp Gly Pro Asp
        2195                2200                2205            
Gln Asn Ser Pro Gln Leu Gly Val Phe Ser Gly Asn Thr Ala Leu Glu
    2210                2215                2220                
Thr Ala Tyr Ser Ser Thr Asn Gln Val Leu Leu Lys Phe His Ser Asp
2225                2230                2235                2240
Phe Ser Asn Gly Gly Phe Phe Val Leu Asn Phe His Ala Phe Gln Leu
                2245                2250                2255    
Lys Lys Cys Gln Pro Pro Pro Ala Val Pro Gln Ala Glu Met Leu Thr
            2260                2265                2270        
Glu Asp Asp Asp Phe Glu Ile Gly Asp Phe Val Lys Tyr Gln Cys His
        2275                2280                2285            
Pro Gly Tyr Thr Leu Val Gly Thr Asp Ile Leu Thr Cys Lys Leu Ser
    2290                2295                2300                
Ser Gln Leu Gln Phe Glu Gly Ser Leu Pro Thr Cys Glu Ala Gln Cys
2305                2310                2315                2320
Pro Ala Asn Glu Val Arg Thr Gly Ser Ser Gly Val Ile Leu Ser Pro
                2325                2330                2335    
Gly Tyr Pro Gly Asn Tyr Phe Asn Ser Gln Thr Cys Ser Trp Ser Ile
            2340                2345                2350        
Lys Val Glu Pro Asn Tyr Asn Ile Thr Ile Phe Val Asp Thr Phe Gln
        2355                2360                2365            
Ser Glu Lys Gln Phe Asp Ala Leu Glu Val Phe Asp Gly Ser Ser Gly
    2370                2375                2380                
Gln Ser Pro Leu Leu Val Val Leu Ser Gly Asn His Thr Glu Gln Ser
2385                2390                2395                2400
Asn Phe Thr Ser Arg Ser Asn Gln Leu Tyr Leu Arg Trp Ser Thr Asp
                2405                2410                2415    
His Ala Thr Ser Lys Lys Gly Phe Lys Ile Arg Tyr Ala Ala Pro Tyr
            2420                2425                2430        
Cys Ser Leu Thr His Pro Leu Lys Asn Gly Gly Ile Leu Asn Arg Thr
        2435                2440                2445            
Ala Gly Ala Val Gly Ser Lys Val His Tyr Phe Cys Lys Pro Gly Tyr
    2450                2455                2460                
Arg Met Val Gly His Ser Asn Ala Thr Cys Arg Arg Asn Pro Leu Gly
2465                2470                2475                2480
Met Tyr Gln Trp Asp Ser Leu Thr Pro Leu Cys Gln Ala Val Ser Cys
                2485                2490                2495    
Gly Ile Pro Glu Ser Pro Gly Asn Gly Ser Phe Thr Gly Asn Glu Phe
            2500                2505                2510        
Thr Leu Asp Ser Lys Val Val Tyr Glu Cys His Glu Gly Phe Lys Leu
        2515                2520                2525            
Glu Ser Ser Gln Gln Ala Thr Ala Val Cys Gln Glu Asp Gly Leu Trp
    2530                2535                2540                
Ser Asn Lys Gly Lys Pro Pro Met Cys Lys Pro Val Ala Cys Pro Ser
2545                2550                2555                2560
Ile Glu Ala Gln Leu Ser Glu His Val Ile Trp Arg Leu Val Ser Gly
                2565                2570                2575    
Ser Leu Asn Glu Tyr Gly Ala Gln Val Leu Leu Ser Cys Ser Pro Gly
            2580                2585                2590        
Tyr Tyr Leu Glu Gly Trp Arg Leu Leu Arg Cys Gln Ala Asn Gly Thr
        2595                2600                2605            
Trp Asn Ile Gly Asp Glu Arg Pro Ser Cys Arg Ala Gly His Cys Gly
    2610                2615                2620                
Ser Pro Asp Pro Ile Val Asn Gly His Ile Ser Gly Asp Gly Phe Ser
2625                2630                2635                2640
Tyr Arg Asp Thr Val Val Tyr Gln Cys Asn Pro Gly Phe Arg Leu Val
                2645                2650                2655    
Gly Thr Ser Val Arg Ile Cys Leu Gln Asp His Lys Trp Ser Gly Gln
            2660                2665                2670        
Thr Pro Val Cys Val Pro Ile Thr Cys Gly His Pro Gly Asn Pro Ala
        2675                2680                2685            
His Gly Phe Thr Asn Gly Ser Glu Phe Asn Leu Asn Asp Val Val Asn
    2690                2695                2700                
Phe Thr Cys Asn Thr Gly Tyr Leu Leu Gln Gly Val Ser Arg Ala Gln
2705                2710                2715                2720
Cys Arg Ser Asn Gly Gln Trp Ser Ser Pro Leu Pro Thr Cys Arg Val
                2725                2730                2735    
Val Asn Cys Ser Asp Pro Gly Phe Val Glu Asn Ala Ile Arg His Gly
            2740                2745                2750        
Gln Gln Asn Phe Pro Glu Ser Phe Glu Tyr Gly Met Ser Ile Leu Tyr
        2755                2760                2765            
His Cys Lys Lys Gly Phe His Leu Leu Gly Ser Ser Ala Leu Thr Cys
    2770                2775                2780                
Met Ala Asn Gly Leu Trp Asp Arg Ser Leu Pro Lys Cys Leu Ala Ile
2785                2790                2795                2800
Ser Cys Gly His Pro Gly Val Pro Ala Asn Ala Val Leu Thr Gly Glu
                2805                2810                2815    
Leu Phe Thr Tyr Gly Ala Val Val His Tyr Ser Cys Arg Gly Ser Glu
            2820                2825                2830        
Ser Leu Ile Gly Asn Asp Thr Arg Val Cys Gln Glu Asp Ser His Trp
        2835                2840                2845            
Ser Gly Ala Leu Pro His Cys Thr Gly Asn Asn Pro Gly Phe Cys Gly
    2850                2855                2860                
Asp Pro Gly Thr Pro Ala His Gly Ser Arg Leu Gly Asp Asp Phe Lys
2865                2870                2875                2880
Thr Lys Ser Leu Leu Arg Phe Ser Cys Glu Met Gly His Gln Leu Arg
                2885                2890                2895    
Gly Ser Pro Glu Arg Thr Cys Leu Leu Asn Gly Ser Trp Ser Gly Leu
            2900                2905                2910        
Gln Pro Val Cys Glu Ala Val Leu Cys Pro Gln Pro Pro Pro Val Gln
        2915                2920                2925            
Asn Gly Thr Val Glu Gly Ser Asp Phe Arg Trp Gly Ser Ser Ile Ser
    2930                2935                2940                
Tyr Ser Cys Met Asp Gly Tyr Gln Leu Ser His Ser Ala Ile Leu Ser
2945                2950                2955                2960
Cys Glu Gly Arg Gly Val Trp Lys Gly Glu Ile Pro Gln Cys Leu Pro
                2965                2970                2975    
Val Phe Cys Gly Asp Pro Gly Ile Pro Ala Glu Gly Arg Leu Ser Gly
            2980                2985                2990        
Lys Ser Phe Thr Tyr Lys Ser Glu Val Phe Phe Gln Cys Lys Ser Pro
        2995                3000                3005            
Phe Ile Leu Val Gly Ser Ser Arg Arg Val Cys Gln Ala Asp Gly Thr
    3010                3015                3020                
Trp Ser Gly Ile Gln Pro Thr Cys Ile Asp Pro Ala His Asn Thr Cys
3025                3030                3035                3040
Pro Asp Pro Gly Thr Pro His Phe Gly Ile Gln Asn Ser Ser Arg Gly
                3045                3050                3055    
Tyr Glu Val Gly Ser Thr Val Phe Phe Arg Cys Arg Lys Gly Tyr His
            3060                3065                3070        
Ile Gln Gly Ser Thr Thr Arg Thr Cys Leu Ala Asn Leu Thr Trp Ser
        3075                3080                3085            
Gly Ile Gln Thr Glu Cys Ile Pro His Ala Cys Arg Gln Pro Glu Thr
    3090                3095                3100                
Pro Ala His Ala Asp Val Arg Ala Ile Asp Leu Pro Thr Phe Gly Tyr
3105                3110                3115                3120
Thr Leu Val Tyr Thr Cys His Pro Gly Phe Phe Leu Ala Gly Gly Ser
                3125                3130                3135    
Glu His Arg Thr Cys Lys Ala Asp Met Lys Trp Thr Gly Lys Ser Pro
            3140                3145                3150        
Val Cys Lys Ser Lys Gly Val Arg Glu Val Asn Glu Thr Val Thr Lys
        3155                3160                3165            
Thr Pro Val Pro Ser Asp Val Phe Phe Val Asn Ser Leu Trp Lys Gly
    3170                3175                3180                
Tyr Tyr Glu Tyr Leu Gly Lys Arg Gln Pro Ala Thr Leu Thr Val Asp
3185                3190                3195                3200
Trp Phe Asn Ala Thr Ser Ser Lys Val Asn Ala Thr Phe Ser Glu Ala
                3205                3210                3215    
Ser Pro Val Glu Leu Lys Leu Thr Gly Ile Tyr Lys Lys Glu Glu Ala
            3220                3225                3230        
His Leu Leu Leu Lys Ala Phe Gln Ile Lys Gly Gln Ala Asp Ile Phe
        3235                3240                3245            
Val Ser Lys Phe Glu Asn Asp Asn Trp Gly Leu Asp Gly Tyr Val Ser
    3250                3255                3260                
Ser Gly Leu Glu Arg Gly Gly Phe Thr Phe Gln Gly Asp Ile His Gly
3265                3270                3275                3280
Lys Asp Phe Gly Lys Phe Lys Leu Glu Arg Gln Asp Pro Leu Asn Pro
                3285                3290                3295    
Asp Gln Asp Ser Ser Ser His Tyr His Gly Thr Ser Ser Gly Ser Val
            3300                3305                3310        
Ala Ala Ala Ile Leu Val Pro Phe Phe Ala Leu Ile Leu Ser Gly Phe
        3315                3320                3325            
Ala Phe Tyr Leu Tyr Lys His Arg Thr Arg Pro Lys Val Gln Tyr Asn
    3330                3335                3340                
Gly Tyr Ala Gly His Glu Asn Ser Asn Gly Gln Ala Ser Phe Glu Asn
3345                3350                3355                3360
Pro Met Tyr Asp Thr Asn Leu Lys Pro Thr Glu Ala Lys Ala Val Arg
                3365                3370                3375    
Phe Asp Thr Thr Leu Asn Thr Val Cys Thr Val Val
            3380                3385            


<210> 9489
<211> 427
<212> PRT
<213> Homo sapiens

<400> 9489
Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu
 1               5                  10                  15      
Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn
            20                  25                  30          
Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val
        35                  40                  45              
Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys
    50                  55                  60                  
Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg
65                  70                  75                  80  
Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp
                85                  90                  95      
Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp
            100                 105                 110         
Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser
        115                 120                 125             
Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly
    130                 135                 140                 
Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met
145                 150                 155                 160 
Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile
                165                 170                 175     
Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr
            180                 185                 190         
Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu
        195                 200                 205             
Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu
    210                 215                 220                 
Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly
225                 230                 235                 240 
Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser
                245                 250                 255     
Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu
            260                 265                 270         
Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp
        275                 280                 285             
Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala
    290                 295                 300                 
Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile
305                 310                 315                 320 
Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr
                325                 330                 335     
Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn
            340                 345                 350         
Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu
        355                 360                 365             
Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser
    370                 375                 380                 
Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr
385                 390                 395                 400 
Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu
                405                 410                 415     
Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile
            420                 425         


<210> 9490
<211> 698
<212> PRT
<213> Homo sapiens

<400> 9490
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val
 1               5                  10                  15      
Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly
            20                  25                  30          
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro
        35                  40                  45              
Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val
    50                  55                  60                  
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu
65                  70                  75                  80  
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe
                85                  90                  95      
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg
            100                 105                 110         
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu
        115                 120                 125             
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr
    130                 135                 140                 
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp
145                 150                 155                 160 
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro
                165                 170                 175     
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys
            180                 185                 190         
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu
        195                 200                 205             
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile
    210                 215                 220                 
Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg
225                 230                 235                 240 
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg
                245                 250                 255     
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val
            260                 265                 270         
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val
        275                 280                 285             
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr
    290                 295                 300                 
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu
305                 310                 315                 320 
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys
                325                 330                 335     
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met
            340                 345                 350         
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg
        355                 360                 365             
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr
    370                 375                 380                 
Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu
385                 390                 395                 400 
Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile
                405                 410                 415     
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val
            420                 425                 430         
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala
        435                 440                 445             
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr
    450                 455                 460                 
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val
465                 470                 475                 480 
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu
                485                 490                 495     
Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly
            500                 505                 510         
Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu
        515                 520                 525             
Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp
    530                 535                 540                 
Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe
545                 550                 555                 560 
Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile
                565                 570                 575     
Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser
            580                 585                 590         
Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu
        595                 600                 605             
Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu
    610                 615                 620                 
Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg
625                 630                 635                 640 
Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile
                645                 650                 655     
Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro
            660                 665                 670         
Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln
        675                 680                 685             
Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val
    690                 695             


<210> 9491
<211> 797
<212> PRT
<213> Homo sapiens

<400> 9491
Met Ala His Arg Cys Leu Arg Leu Trp Gly Arg Gly Gly Cys Trp Pro
 1               5                  10                  15      
Arg Gly Leu Gln Gln Leu Leu Val Pro Gly Gly Val Gly Pro Gly Glu
            20                  25                  30          
Gln Pro Cys Leu Arg Thr Leu Tyr Arg Phe Val Thr Thr Gln Ala Arg
        35                  40                  45              
Ala Ser Arg Asn Ser Leu Leu Thr Asp Ile Ile Ala Ala Tyr Gln Arg
    50                  55                  60                  
Phe Cys Ser Arg Pro Pro Lys Gly Phe Gly Lys Tyr Phe Pro Asn Gly
65                  70                  75                  80  
Lys Asn Gly Lys Lys Ala Ser Glu Pro Lys Glu Val Met Gly Glu Lys
                85                  90                  95      
Lys Glu Ser Lys Pro Ala Ala Thr Thr Arg Ser Ser Gly Gly Gly Gly
            100                 105                 110         
Gly Gly Gly Gly Lys Arg Gly Gly Lys Lys Asp Asp Ser His Trp Trp
        115                 120                 125             
Ser Arg Phe Gln Lys Gly Asp Ile Pro Trp Asp Asp Lys Asp Phe Arg
    130                 135                 140                 
Met Phe Phe Leu Trp Thr Ala Leu Phe Trp Gly Gly Val Met Phe Tyr
145                 150                 155                 160 
Leu Leu Leu Lys Arg Ser Gly Arg Glu Ile Thr Trp Lys Asp Phe Val
                165                 170                 175     
Asn Asn Tyr Leu Ser Lys Gly Val Val Asp Arg Leu Glu Val Val Asn
            180                 185                 190         
Lys Arg Phe Val Arg Val Thr Phe Thr Pro Gly Lys Thr Pro Val Asp
        195                 200                 205             
Gly Gln Tyr Val Trp Phe Asn Ile Gly Ser Val Asp Thr Phe Glu Arg
    210                 215                 220                 
Asn Leu Glu Thr Leu Gln Gln Glu Leu Gly Ile Glu Gly Glu Asn Arg
225                 230                 235                 240 
Val Pro Val Val Tyr Ile Ala Glu Ser Asp Gly Ser Phe Leu Leu Ser
                245                 250                 255     
Met Leu Pro Thr Val Leu Ile Ile Ala Phe Leu Leu Tyr Thr Ile Arg
            260                 265                 270         
Arg Gly Pro Ala Gly Ile Gly Arg Thr Gly Arg Gly Met Gly Gly Leu
        275                 280                 285             
Phe Ser Val Gly Glu Thr Thr Ala Lys Val Leu Lys Asp Glu Ile Asp
    290                 295                 300                 
Val Lys Phe Lys Asp Val Ala Gly Cys Glu Glu Ala Lys Leu Glu Ile
305                 310                 315                 320 
Met Glu Phe Val Asn Phe Leu Lys Asn Pro Lys Gln Tyr Gln Asp Leu
                325                 330                 335     
Gly Ala Lys Ile Pro Lys Gly Ala Ile Leu Thr Gly Pro Pro Gly Thr
            340                 345                 350         
Gly Lys Thr Leu Leu Ala Lys Ala Thr Ala Gly Glu Ala Asn Val Pro
        355                 360                 365             
Phe Ile Thr Val Ser Gly Ser Glu Phe Leu Glu Met Phe Val Gly Val
    370                 375                 380                 
Gly Pro Ala Arg Val Arg Asp Leu Phe Ala Leu Ala Arg Lys Asn Ala
385                 390                 395                 400 
Pro Cys Ile Leu Phe Ile Asp Glu Ile Asp Ala Val Gly Arg Lys Arg
                405                 410                 415     
Gly Arg Gly Asn Phe Gly Gly Gln Ser Glu Gln Glu Asn Thr Leu Asn
            420                 425                 430         
Gln Leu Leu Val Glu Met Asp Gly Phe Asn Thr Thr Thr Asn Val Val
        435                 440                 445             
Ile Leu Ala Gly Thr Asn Arg Pro Asp Ile Leu Asp Pro Ala Leu Leu
    450                 455                 460                 
Arg Pro Gly Arg Phe Asp Arg Gln Ile Phe Ile Gly Pro Pro Asp Ile
465                 470                 475                 480 
Lys Gly Arg Ala Ser Ile Phe Lys Val His Leu Arg Pro Leu Lys Leu
                485                 490                 495     
Asp Ser Thr Leu Glu Lys Asp Lys Leu Ala Arg Lys Leu Ala Ser Leu
            500                 505                 510         
Thr Pro Gly Phe Ser Gly Ala Asp Val Ala Asn Val Cys Asn Glu Ala
        515                 520                 525             
Ala Leu Ile Ala Ala Arg His Leu Ser Asp Ser Ile Asn Gln Lys His
    530                 535                 540                 
Phe Glu Gln Ala Ile Glu Arg Val Ile Gly Gly Leu Glu Lys Lys Thr
545                 550                 555                 560 
Gln Val Leu Gln Pro Glu Glu Lys Lys Thr Val Ala Tyr His Glu Ala
                565                 570                 575     
Gly His Ala Val Ala Gly Trp Tyr Leu Glu His Ala Asp Pro Leu Leu
            580                 585                 590         
Lys Val Ser Ile Ile Pro Arg Gly Lys Gly Leu Gly Tyr Ala Gln Tyr
        595                 600                 605             
Leu Pro Lys Glu Gln Tyr Leu Tyr Thr Lys Glu Gln Leu Leu Asp Arg
    610                 615                 620                 
Met Cys Met Thr Leu Gly Gly Arg Ala Ser Glu Glu Ile Phe Phe Gly
625                 630                 635                 640 
Arg Ile Thr Thr Gly Ala Gln Asp Asp Leu Arg Lys Val Thr Gln Ser
                645                 650                 655     
Ala Tyr Ala Gln Ile Val Gln Phe Gly Met Asn Glu Lys Val Gly Gln
            660                 665                 670         
Ile Ser Phe Asp Leu Pro Arg Gln Gly Asp Met Val Leu Glu Lys Pro
        675                 680                 685             
Tyr Ser Glu Ala Thr Ala Arg Leu Ile Asp Asp Glu Val Arg Ile Leu
    690                 695                 700                 
Ile Asn Asp Ala Tyr Lys Arg Thr Val Ala Leu Leu Thr Glu Lys Lys
705                 710                 715                 720 
Ala Asp Val Glu Lys Val Ala Leu Leu Leu Leu Glu Lys Glu Val Leu
                725                 730                 735     
Asp Lys Asn Asp Met Val Glu Leu Leu Gly Pro Arg Pro Phe Ala Glu
            740                 745                 750         
Lys Ser Thr Tyr Glu Glu Phe Val Glu Gly Thr Gly Ser Leu Asp Glu
        755                 760                 765             
Asp Thr Ser Leu Pro Glu Gly Leu Lys Asp Trp Asn Lys Glu Arg Glu
    770                 775                 780                 
Lys Glu Lys Glu Glu Pro Pro Gly Glu Lys Val Ala Asn
785                 790                 795         


<210> 9492
<211> 338
<212> PRT
<213> Homo sapiens

<400> 9492
Met Ile Asn Ser Thr Ser Thr Gln Pro Pro Asp Glu Ser Cys Ser Gln
 1               5                  10                  15      
Asn Leu Leu Ile Thr Gln Gln Ile Ile Pro Val Leu Tyr Cys Met Val
            20                  25                  30          
Phe Ile Ala Gly Ile Leu Leu Asn Gly Val Ser Gly Trp Ile Phe Phe
        35                  40                  45              
Tyr Val Pro Ser Ser Lys Ser Phe Ile Ile Tyr Leu Lys Asn Ile Val
    50                  55                  60                  
Ile Ala Asp Phe Val Met Ser Leu Thr Phe Pro Phe Lys Ile Leu Gly
65                  70                  75                  80  
Asp Ser Gly Leu Gly Pro Trp Gln Leu Asn Val Phe Val Cys Arg Val
                85                  90                  95      
Ser Ala Val Leu Phe Tyr Val Asn Met Tyr Val Ser Ile Val Phe Phe
            100                 105                 110         
Gly Leu Ile Ser Phe Asp Arg Tyr Tyr Lys Ile Val Lys Pro Leu Trp
        115                 120                 125             
Thr Ser Phe Ile Gln Ser Val Ser Tyr Ser Lys Leu Leu Ser Val Ile
    130                 135                 140                 
Val Trp Met Leu Met Leu Leu Leu Ala Val Pro Asn Ile Ile Leu Thr
145                 150                 155                 160 
Asn Gln Ser Val Arg Glu Val Thr Gln Ile Lys Cys Ile Glu Leu Lys
                165                 170                 175     
Ser Glu Leu Gly Arg Lys Trp His Lys Ala Ser Asn Tyr Ile Phe Val
            180                 185                 190         
Ala Ile Phe Trp Ile Val Phe Leu Leu Leu Ile Val Phe Tyr Thr Ala
        195                 200                 205             
Ile Thr Lys Lys Ile Phe Lys Ser His Leu Lys Ser Ser Arg Asn Ser
    210                 215                 220                 
Thr Ser Val Lys Lys Lys Ser Ser Arg Asn Ile Phe Ser Ile Val Phe
225                 230                 235                 240 
Val Phe Phe Val Cys Phe Val Pro Tyr His Ile Ala Arg Ile Pro Tyr
                245                 250                 255     
Thr Lys Ser Gln Thr Glu Ala His Tyr Ser Cys Gln Ser Lys Glu Ile
            260                 265                 270         
Leu Arg Tyr Met Lys Glu Phe Thr Leu Leu Leu Ser Ala Ala Asn Val
        275                 280                 285             
Cys Leu Asp Pro Ile Ile Tyr Phe Phe Leu Cys Gln Pro Phe Arg Glu
    290                 295                 300                 
Ile Leu Cys Lys Lys Leu His Ile Pro Leu Lys Ala Gln Asn Asp Leu
305                 310                 315                 320 
Asp Ile Ser Arg Ile Lys Arg Gly Asn Thr Thr Leu Glu Ser Thr Asp
                325                 330                 335     
Thr Leu
        


<210> 9493
<211> 1474
<212> PRT
<213> Homo sapiens

<400> 9493
Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Thr Ala Val
 1               5                  10                  15      
Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe
            20                  25                  30          
Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu
        35                  40                  45              
Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly
    50                  55                  60                  
Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn
65                  70                  75                  80  
Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys
                85                  90                  95      
Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro
            100                 105                 110         
Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys
        115                 120                 125             
Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu
    130                 135                 140                 
Gln Lys Val Leu Glu Pro Thr Ser Thr His Glu Ser Glu His Gln Ser
145                 150                 155                 160 
Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val
                165                 170                 175     
Met Pro Trp Ile Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser
            180                 185                 190         
Trp Glu Asp Tyr Val Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro
        195                 200                 205             
Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe
    210                 215                 220                 
Tyr Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr
225                 230                 235                 240 
Arg Ile Lys Ser Gly Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp
                245                 250                 255     
Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val
            260                 265                 270         
Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly
        275                 280                 285             
Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly
    290                 295                 300                 
Thr Trp Glu Thr Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met
305                 310                 315                 320 
Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp
                325                 330                 335     
Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala
            340                 345                 350         
Asn Arg Glu Glu Pro Val Ser Leu Thr Phe Pro Asn Pro Tyr Gln Phe
        355                 360                 365             
Ile Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp
    370                 375                 380                 
Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp
385                 390                 395                 400 
Pro Ser Ala Gly Pro Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr
                405                 410                 415     
Ala Arg Pro Thr Pro Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr
            420                 425                 430         
Pro Leu Arg Arg Ala Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn
        435                 440                 445             
Gln Leu Gly Pro Asp Leu Pro Pro Ala Thr Ala Pro Val Pro Ser Thr
    450                 455                 460                 
Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys
465                 470                 475                 480 
Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly
                485                 490                 495     
Met Leu Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser
            500                 505                 510         
Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp
        515                 520                 525             
Leu Ser Asn Cys Thr Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile
    530                 535                 540                 
Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His
545                 550                 555                 560 
Thr Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu
                565                 570                 575     
Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg
            580                 585                 590         
Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys
        595                 600                 605             
Arg Glu Arg Thr Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val
    610                 615                 620                 
Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn
625                 630                 635                 640 
Ala Thr Glu Gln Val His Thr Ala Thr Met Leu Leu Asp Val Leu Glu
                645                 650                 655     
Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe
            660                 665                 670         
Leu Ala Ala Lys Glu Asn Val Val Leu Glu Val Thr Val Leu Asn Thr
        675                 680                 685             
Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg
    690                 695                 700                 
Lys Asn Ser Ile Gln Leu Ser Ala Lys Thr Ile Lys Gln Asn Ser Arg
705                 710                 715                 720 
Asn Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu
                725                 730                 735     
Phe Leu Ser Thr Glu Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly
            740                 745                 750         
Pro Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile
        755                 760                 765             
Ala Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro
    770                 775                 780                 
Val Ile Phe Thr Val Ala His Leu Glu Asp Lys Asn His Phe Asn Ala
785                 790                 795                 800 
Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp
                805                 810                 815     
Ser Thr Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr
            820                 825                 830         
Cys Ala Cys Ser His Leu Thr Asn Phe Ala Val Leu Met Ala His Arg
        835                 840                 845             
Glu Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr
    850                 855                 860                 
Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser
865                 870                 875                 880 
Thr Phe Cys Phe Leu Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His
                885                 890                 895     
Lys Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val
            900                 905                 910         
Gly Ile Asp Lys Thr Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly
        915                 920                 925             
Leu Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu
    930                 935                 940                 
Gly Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr
945                 950                 955                 960 
Ser Arg Thr Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu
                965                 970                 975     
Val Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu
            980                 985                 990         
Lys Ala Cys Trp Leu Arg Val Asp Asn Tyr Phe Ile Trp Ser Phe Ile
        995                 1000                1005            
Gly Pro Val Ser Phe Val Ile Val Val Asn Leu Val Phe Leu Met Val
    1010                1015                1020                
Thr Leu His Lys Met Ile Arg Ser Ser Ser Val Leu Lys Pro Asp Ser
1025                1030                1035                1040
Ser Arg Leu Asp Asn Ile Lys Ser Trp Ala Leu Gly Ala Ile Ala Leu
                1045                1050                1055    
Leu Phe Leu Leu Gly Leu Thr Trp Ala Phe Gly Leu Leu Phe Ile Asn
            1060                1065                1070        
Lys Glu Ser Val Val Met Ala Tyr Leu Phe Thr Thr Phe Asn Ala Phe
        1075                1080                1085            
Gln Gly Val Phe Ile Phe Val Phe His Cys Ala Leu Gln Lys Lys Val
    1090                1095                1100                
His Lys Glu Tyr Ser Lys Cys Leu Arg His Ser Tyr Cys Cys Ile Arg
1105                1110                1115                1120
Ser Pro Pro Gly Gly Thr His Gly Ser Leu Lys Thr Ser Ala Met Arg
                1125                1130                1135    
Ser Asn Thr Arg Tyr Tyr Thr Gly Thr Gln Ser Arg Ile Arg Arg Met
            1140                1145                1150        
Trp Asn Asp Thr Val Arg Lys Gln Thr Glu Ser Ser Phe Met Ala Gly
        1155                1160                1165            
Asp Ile Asn Ser Thr Pro Thr Leu Asn Arg Gly Thr Met Gly Asn His
    1170                1175                1180                
Leu Leu Thr Asn Pro Val Leu Gln Pro Arg Gly Gly Thr Ser Pro Tyr
1185                1190                1195                1200
Asn Thr Leu Ile Ala Glu Ser Val Gly Phe Asn Pro Ser Ser Pro Pro
                1205                1210                1215    
Val Phe Asn Ser Pro Gly Ser Tyr Arg Glu Pro Lys His Pro Leu Gly
            1220                1225                1230        
Gly Arg Glu Ala Cys Gly Met Asp Thr Leu Pro Leu Asn Gly Asn Phe
        1235                1240                1245            
Asn Asn Ser Tyr Ser Leu Arg Ser Gly Asp Phe Pro Pro Gly Asp Gly
    1250                1255                1260                
Gly Pro Glu Pro Pro Arg Gly Arg Asn Leu Ala Asp Ala Ala Ala Phe
1265                1270                1275                1280
Glu Lys Met Ile Ile Ser Glu Leu Val His Asn Asn Leu Arg Gly Ser
                1285                1290                1295    
Ser Ser Ala Ala Lys Gly Pro Pro Pro Pro Glu Pro Pro Val Pro Pro
            1300                1305                1310        
Val Pro Gly Gly Gly Gly Glu Glu Glu Ala Gly Gly Pro Gly Gly Ala
        1315                1320                1325            
Asp Arg Ala Glu Ile Glu Leu Leu Tyr Lys Ala Leu Glu Glu Pro Leu
    1330                1335                1340                
Leu Leu Pro Arg Ala Gln Ser Val Leu Tyr Gln Ser Asp Leu Asp Glu
1345                1350                1355                1360
Ser Glu Ser Cys Thr Ala Glu Asp Gly Ala Thr Ser Arg Pro Leu Ser
                1365                1370                1375    
Ser Pro Pro Gly Arg Asp Ser Leu Tyr Ala Ser Gly Ala Asn Leu Arg
            1380                1385                1390        
Asp Ser Pro Ser Tyr Pro Asp Ser Ser Pro Glu Gly Pro Ser Glu Ala
        1395                1400                1405            
Leu Pro Pro Pro Pro Pro Ala Pro Pro Gly Pro Pro Glu Ile Tyr Tyr
    1410                1415                1420                
Thr Ser Arg Pro Pro Ala Leu Val Ala Arg Asn Pro Leu Gln Gly Tyr
1425                1430                1435                1440
Tyr Gln Val Arg Arg Pro Ser His Glu Gly Tyr Leu Ala Ala Pro Gly
                1445                1450                1455    
Leu Glu Gly Pro Gly Pro Asp Gly Asp Gly Gln Met Gln Leu Val Thr
            1460                1465                1470        
Ser Leu
        


<210> 9494
<211> 210
<212> PRT
<213> Homo sapiens

<400> 9494
Met Val Cys Gly Gly Phe Ala Cys Ser Lys Asn Ala Leu Cys Ala Leu
 1               5                  10                  15      
Asn Val Val Tyr Met Leu Val Ser Leu Leu Leu Ile Gly Val Ala Ala
            20                  25                  30          
Trp Gly Lys Gly Leu Gly Leu Val Ser Ser Ile His Ile Ile Gly Gly
        35                  40                  45              
Val Ile Ala Val Gly Val Phe Leu Leu Leu Ile Ala Val Ala Gly Leu
    50                  55                  60                  
Val Gly Ala Val Asn His His Gln Val Leu Leu Phe Phe Tyr Met Ile
65                  70                  75                  80  
Ile Leu Gly Leu Val Phe Ile Phe Gln Phe Val Ile Ser Cys Ser Cys
                85                  90                  95      
Leu Ala Ile Asn Arg Ser Lys Gln Thr Asp Val Ile Asn Ala Ser Trp
            100                 105                 110         
Trp Val Met Ser Asn Lys Thr Arg Asp Glu Leu Glu Arg Ser Phe Asp
        115                 120                 125             
Cys Cys Gly Leu Phe Asn Leu Thr Thr Leu Tyr Gln Gln Asp Tyr Asp
    130                 135                 140                 
Phe Cys Thr Ala Ile Cys Lys Ser Gln Ser Pro Thr Cys Gln Met Cys
145                 150                 155                 160 
Gly Glu Lys Phe Leu Lys His Ser Asp Glu Ala Leu Lys Ile Leu Gly
                165                 170                 175     
Gly Val Gly Leu Phe Phe Ser Phe Thr Glu Ile Leu Gly Val Trp Leu
            180                 185                 190         
Ala Met Arg Phe Arg Asn Gln Lys Asp Pro Arg Ala Asn Pro Ser Ala
        195                 200                 205             
Phe Leu
    210 


<210> 9495
<211> 3522
<212> PRT
<213> Homo sapiens

<400> 9495
Met Ala Val Thr Gly Leu Ser Gly Gln Ile Ser Ser Ala Pro Leu Asp
 1               5                  10                  15      
Leu Pro Ala Ile Lys Leu Ala Tyr Ser Thr Ser His Glu Leu Cys Met
            20                  25                  30          
Val Leu Val Leu Leu Trp Arg Glu Pro Pro Ser Leu Ile Leu Ser Asn
        35                  40                  45              
Pro Asp Ala Phe Met Lys Gly Thr Asn Glu Arg Gln Asn Gly Arg Glu
    50                  55                  60                  
Ala Asp Gly Leu Leu Glu Lys Glu Leu Tyr Ala Ala Glu Gly Glu Ala
65                  70                  75                  80  
Ser Leu Gly Pro Gly Pro Val Gln Arg His Met Lys Gly Glu Glu Leu
                85                  90                  95      
Arg Arg Arg Val Ser Ser Ala Lys Ile Ala Arg Ser Asn Gln Glu Asn
            100                 105                 110         
Gln Ser Glu Gly Arg Cys Arg Val Leu Trp Lys Lys Ser Gly Asp Gly
        115                 120                 125             
Gln Asp Arg Gly Lys Val Thr Val Thr Asp Gly Gly Pro Ser Pro Lys
    130                 135                 140                 
Gln Ser Thr Ile Trp Val Val Val Gln Val Leu Asp Glu Asn Asp Asn
145                 150                 155                 160 
Lys Pro Gln Phe Pro Glu Lys Val Tyr Gln Ile Lys Leu Pro Glu Arg
                165                 170                 175     
Asp Arg Lys Lys Arg Gly Glu Pro Ile Tyr Arg Ala Phe Ala Phe Asp
            180                 185                 190         
Arg Asp Glu Gly Pro Asn Ala Glu Ile Ser Tyr Ser Ile Val Asp Gly
        195                 200                 205             
Asn Asp Asp Gly Lys Phe Phe Ile Asp Pro Lys Thr Gly Met Val Ser
    210                 215                 220                 
Ser Arg Lys Gln Phe Thr Ala Gly Ser Tyr Asp Ile Leu Thr Ile Lys
225                 230                 235                 240 
Ala Val Asp Asn Gly Arg Pro Gln Lys Ser Ser Thr Ala Arg Leu His
                245                 250                 255     
Ile Glu Trp Ile Lys Lys Pro Pro Pro Ser Pro Ile Pro Leu Thr Phe
            260                 265                 270         
Asp Glu Pro Phe Tyr Asn Phe Thr Val Met Glu Ser Asp Arg Val Thr
        275                 280                 285             
Glu Ile Val Gly Val Val Ser Val Gln Pro Ala Asn Thr Pro Leu Trp
    290                 295                 300                 
Phe Asp Ile Val Gly Gly Lys His Ala Arg Glu Met Phe Tyr Ile Leu
305                 310                 315                 320 
Gln Thr Ala Cys Gly Gln Asn Cys Ser Thr Glu Gly Gly Asn Phe Asp
                325                 330                 335     
Ser Ala Phe Asp Ala Glu Lys Gly Val Gly Thr Ile Val Ile Ala Lys
            340                 345                 350         
Pro Leu Asp Ala Glu Gln Arg Ser Ile Tyr Asn Met Ser Val Glu Val
        355                 360                 365             
Thr Asp Gly Thr Asn Val Ala Val Thr Gln Val Phe Ile Lys Val Leu
    370                 375                 380                 
Asp Asn Asn Asp Asn Gly Pro Glu Phe Ser Gln Pro Asn Tyr Asp Val
385                 390                 395                 400 
Thr Ile Ser Glu Asp Val Leu Pro Asp Thr Glu Ile Leu Gln Ile Glu
                405                 410                 415     
Ala Thr Asp Arg Asp Glu Lys His Lys Leu Ser Tyr Thr Val His Ser
            420                 425                 430         
Ser Ile Asp Ser Ile Ser Met Arg Lys Phe Arg Ile Asp Pro Ser Thr
        435                 440                 445             
Gly Val Leu Tyr Thr Ala Glu Arg Leu Asp His Glu Ala Gln Asp Lys
    450                 455                 460                 
His Ile Leu Asn Ile Met Val Arg Asp Gln Glu Phe Pro Tyr Arg Arg
465                 470                 475                 480 
Asn Leu Ala Arg Val Ile Val Asn Val Glu Asp Ala Asn Asp His Ser
                485                 490                 495     
Pro Tyr Phe Thr Asn Pro Leu Tyr Glu Ala Ser Val Phe Glu Ser Ala
            500                 505                 510         
Ala Leu Gly Ser Ala Val Leu Gln Val Thr Ala Leu Asp Lys Asp Lys
        515                 520                 525             
Gly Glu Asn Ala Glu Leu Ile Tyr Thr Ile Glu Ala Gly Asn Thr Gly
    530                 535                 540                 
Asn Met Phe Lys Ile Glu Pro Val Leu Gly Ile Ile Thr Ile Cys Lys
545                 550                 555                 560 
Glu Pro Asp Met Thr Thr Met Gly Gln Phe Val Leu Ser Ile Lys Val
                565                 570                 575     
Thr Asp Gln Gly Ser Pro Pro Met Ser Ala Thr Ala Ile Val Arg Ile
            580                 585                 590         
Ser Val Thr Met Ser Asp Asn Ser His Pro Lys Phe Ile His Lys Asp
        595                 600                 605             
Tyr Gln Ala Glu Val Asn Glu Asn Val Asp Ile Gly Thr Ser Val Ile
    610                 615                 620                 
Leu Ile Ser Ala Ile Ser Gln Ser Thr Leu Ile Tyr Glu Val Lys Asp
625                 630                 635                 640 
Gly Asp Ile Asn Gly Ile Phe Thr Ile Asn Pro Tyr Ser Gly Val Ile
                645                 650                 655     
Thr Thr Gln Lys Ala Leu Asp Tyr Glu Arg Thr Ser Ser Tyr Gln Leu
            660                 665                 670         
Ile Ile Gln Ala Thr Asn Met Ala Gly Met Ala Ser Asn Ala Thr Val
        675                 680                 685             
Asn Ile Gln Ile Val Asp Glu Asn Asp Asn Ala Pro Val Phe Leu Phe
    690                 695                 700                 
Ser Gln Tyr Ser Gly Ser Leu Ser Glu Ala Ala Pro Ile Asn Ser Ile
705                 710                 715                 720 
Val Arg Ser Leu Asp Asn Ser Pro Leu Val Ile Arg Ala Thr Asp Ala
                725                 730                 735     
Asp Ser Asn Arg Asn Ala Leu Leu Val Tyr Gln Ile Val Glu Ser Thr
            740                 745                 750         
Ala Lys Lys Phe Phe Thr Val Asp Ser Ser Thr Gly Ala Ile Arg Thr
        755                 760                 765             
Ile Ala Asn Leu Asp His Glu Thr Ile Ala His Phe His Phe His Val
    770                 775                 780                 
His Val Arg Asp Ser Gly Ser Pro Gln Leu Thr Ala Glu Ser Pro Val
785                 790                 795                 800 
Glu Val Asn Ile Glu Val Thr Asp Val Asn Asp Asn Pro Pro Val Phe
                805                 810                 815     
Thr Gln Ala Val Phe Glu Thr Ile Leu Leu Leu Pro Thr Tyr Val Gly
            820                 825                 830         
Val Glu Val Leu Lys Val Ser Ala Thr Asp Pro Asp Ser Glu Val Pro
        835                 840                 845             
Pro Glu Leu Thr Tyr Ser Leu Met Glu Gly Ser Leu Asp His Phe Leu
    850                 855                 860                 
Ile Asp Ser Asn Ser Gly Val Leu Thr Ile Lys Asn Asn Asn Leu Ser
865                 870                 875                 880 
Lys Asp His Tyr Met Leu Ile Val Lys Val Ser Asp Gly Lys Phe Tyr
                885                 890                 895     
Ser Thr Ser Met Val Thr Ile Met Val Lys Glu Ala Met Asp Ser Gly
            900                 905                 910         
Leu His Phe Thr Gln Ser Phe Tyr Ser Thr Ser Ile Ser Glu Asn Asn
        915                 920                 925             
Thr Asn Ile Thr Lys Val Ala Ile Val Asn Ala Val Gly Asn Arg Leu
    930                 935                 940                 
Asn Glu Pro Leu Lys Tyr Ser Ile Leu Asn Pro Gly Asn Lys Phe Lys
945                 950                 955                 960 
Ile Lys Ser Thr Ser Gly Val Ile Gln Thr Thr Gly Val Pro Phe Asp
                965                 970                 975     
Arg Glu Glu Gln Glu Leu Tyr Glu Leu Val Val Glu Ala Ser Arg Glu
            980                 985                 990         
Leu Asp His Leu Arg Val Ala Arg Val Val Val Arg Val Asn Ile Glu
        995                 1000                1005            
Asp Ile Asn Asp Asn Ser Pro Val Phe Val Gly Leu Pro Tyr Tyr Ala
    1010                1015                1020                
Ala Val Gln Val Asp Ala Glu Pro Gly Thr Leu Ile Tyr Gln Val Thr
1025                1030                1035                1040
Ala Ile Asp Lys Asp Lys Gly Pro Asn Gly Glu Val Thr Tyr Val Leu
                1045                1050                1055    
Gln Asp Asp Tyr Gly His Phe Glu Ile Asn Pro Asn Ser Gly Asn Val
            1060                1065                1070        
Ile Leu Lys Glu Ala Phe Asn Ser Asp Leu Ser Asn Ile Glu Tyr Gly
        1075                1080                1085            
Val Thr Ile Leu Ala Lys Asp Gly Gly Lys Pro Ser Leu Ser Thr Ser
    1090                1095                1100                
Val Glu Leu Pro Ile Thr Ile Val Asn Lys Ala Met Pro Val Phe Asp
1105                1110                1115                1120
Lys Pro Phe Tyr Thr Ala Ser Val Asn Glu Asp Ile Arg Met Asn Thr
                1125                1130                1135    
Pro Ile Leu Ser Ile Asn Ala Thr Ser Pro Glu Gly Gln Gly Ile Ile
            1140                1145                1150        
Tyr Ile Ile Ile Asp Gly Asp Pro Phe Lys Gln Phe Asn Ile Asp Phe
        1155                1160                1165            
Asp Thr Gly Val Leu Lys Val Val Ser Pro Leu Asp Tyr Glu Val Thr
    1170                1175                1180                
Ser Ala Tyr Lys Leu Thr Ile Arg Ala Ser Asp Ala Leu Thr Gly Ala
1185                1190                1195                1200
Arg Ala Glu Val Thr Val Asp Leu Leu Val Asn Asp Val Asn Asp Asn
                1205                1210                1215    
Pro Pro Ile Phe Asp Gln Pro Thr Tyr Asn Thr Thr Leu Ser Glu Ala
            1220                1225                1230        
Ser Leu Ile Gly Thr Pro Val Leu Gln Val Val Ser Ile Asp Ala Asp
        1235                1240                1245            
Ser Glu Asn Asn Lys Met Val His Tyr Gln Ile Val Gln Asp Thr Tyr
    1250                1255                1260                
Asn Ser Thr Asp Tyr Phe His Ile Asp Ser Ser Ser Gly Leu Ile Leu
1265                1270                1275                1280
Thr Ala Arg Met Leu Asp His Glu Leu Val Gln His Cys Thr Leu Lys
                1285                1290                1295    
Val Arg Ser Ile Asp Ser Gly Phe Pro Ser Leu Ser Ser Glu Val Leu
            1300                1305                1310        
Val His Ile Tyr Ile Ser Asp Val Asn Asp Asn Pro Pro Val Phe Asn
        1315                1320                1325            
Gln Leu Ile Tyr Glu Ser Tyr Val Ser Glu Leu Ala Pro Arg Gly His
    1330                1335                1340                
Phe Val Thr Cys Val Gln Ala Ser Asp Ala Asp Ser Ser Asp Phe Asp
1345                1350                1355                1360
Arg Leu Glu Tyr Ser Ile Leu Ser Gly Asn Asp Arg Thr Ser Phe Leu
                1365                1370                1375    
Met Asp Ser Lys Ser Gly Val Ile Thr Leu Ser Asn His Arg Lys Gln
            1380                1385                1390        
Arg Met Glu Pro Leu Tyr Ser Leu Asn Val Ser Val Ser Asp Gly Leu
        1395                1400                1405            
Phe Thr Ser Thr Ala Gln Val His Ile Arg Val Leu Gly Ala Asn Leu
    1410                1415                1420                
Tyr Ser Pro Ala Phe Ser Gln Ser Thr Tyr Val Ala Glu Val Arg Glu
1425                1430                1435                1440
Asn Val Ala Ala Gly Thr Lys Val Ile His Val Arg Ala Thr Asp Gly
                1445                1450                1455    
Asp Pro Gly Thr Tyr Gly Gln Ile Ser Tyr Ala Ile Ile Asn Asp Phe
            1460                1465                1470        
Ala Lys Asp Arg Phe Leu Ile Asp Ser Asn Gly Gln Val Ile Thr Thr
        1475                1480                1485            
Glu Arg Leu Asp Arg Glu Asn Pro Leu Glu Gly Asp Val Ser Ile Phe
    1490                1495                1500                
Val Arg Ala Leu Asp Gly Gly Gly Arg Thr Thr Phe Cys Thr Val Arg
1505                1510                1515                1520
Val Ile Val Val Asp Glu Asn Asp Asn Ala Pro Gln Phe Met Thr Val
                1525                1530                1535    
Glu Tyr Arg Ala Ser Val Arg Ala Asp Val Gly Arg Gly His Leu Val
            1540                1545                1550        
Thr Gln Val Gln Ala Ile Asp Pro Asp Asp Gly Ala Asn Ser Arg Ile
        1555                1560                1565            
Thr Tyr Ser Leu Tyr Ser Glu Ala Ser Val Ser Val Ala Asp Leu Leu
    1570                1575                1580                
Glu Ile Asp Pro Asp Asn Gly Trp Met Val Thr Lys Gly Asn Phe Asn
1585                1590                1595                1600
Gln Leu Lys Asn Thr Val Leu Ser Phe Phe Val Lys Ala Val Asp Gly
                1605                1610                1615    
Gly Ile Pro Val Lys His Ser Leu Ile Pro Val Tyr Ile His Val Leu
            1620                1625                1630        
Pro Pro Glu Thr Phe Leu Pro Ser Phe Thr Gln Ser Gln Tyr Ser Phe
        1635                1640                1645            
Thr Ile Ala Glu Asp Thr Ala Ile Gly Ser Thr Val Asp Thr Leu Arg
    1650                1655                1660                
Ile Leu Pro Ser Gln Asn Val Trp Phe Ser Thr Val Asn Gly Glu Arg
1665                1670                1675                1680
Pro Glu Asn Asn Lys Gly Gly Ile Phe Val Ile Glu Gln Glu Thr Gly
                1685                1690                1695    
Thr Ile Lys Leu Asp Lys Arg Leu Asp Arg Glu Thr Ser Pro Ala Phe
            1700                1705                1710        
His Phe Lys Val Ala Ala Thr Ile Pro Leu Asp Lys Val Asp Ile Val
        1715                1720                1725            
Phe Thr Val Asp Val Asp Ile Lys Val Leu Asp Leu Asn Asp Asn Lys
    1730                1735                1740                
Pro Val Phe Glu Thr Ser Ser Tyr Asp Thr Ile Ile Met Glu Gly Met
1745                1750                1755                1760
Pro Val Gly Thr Lys Leu Thr Gln Val Arg Ala Ile Asp Met Asp Trp
                1765                1770                1775    
Gly Ala Asn Gly Gln Val Thr Tyr Ser Leu His Ser Asp Ser Gln Pro
            1780                1785                1790        
Glu Lys Val Met Glu Ala Phe Asn Ile Asp Ser Asn Thr Gly Trp Ile
        1795                1800                1805            
Ser Thr Leu Lys Asp Leu Asp His Glu Thr Asp Pro Thr Phe Thr Phe
    1810                1815                1820                
Ser Val Val Ala Ser Asp Leu Gly Glu Ala Phe Ser Leu Ser Ser Thr
1825                1830                1835                1840
Ala Leu Val Ser Val Arg Val Thr Asp Ile Asn Asp Asn Ala Pro Val
                1845                1850                1855    
Phe Ala Gln Glu Val Tyr Arg Gly Asn Val Lys Glu Ser Asp Pro Pro
            1860                1865                1870        
Gly Glu Val Val Ala Val Leu Ser Thr Trp Asp Arg Asp Thr Ser Asp
        1875                1880                1885            
Val Asn Arg Gln Val Ser Tyr His Ile Thr Gly Gly Asn Pro Arg Gly
    1890                1895                1900                
Arg Phe Ala Leu Gly Leu Val Gln Ser Glu Trp Lys Val Tyr Val Lys
1905                1910                1915                1920
Arg Pro Leu Asp Arg Glu Glu Gln Asp Ile Tyr Phe Leu Asn Ile Thr
                1925                1930                1935    
Ala Thr Asp Gly Leu Phe Val Thr Gln Ala Met Val Glu Val Ser Val
            1940                1945                1950        
Ser Asp Val Asn Asp Asn Ser Pro Val Cys Asp Gln Val Ala Tyr Thr
        1955                1960                1965            
Ala Leu Leu Pro Glu Asp Ile Pro Ser Asn Lys Ile Ile Leu Lys Val
    1970                1975                1980                
Ser Ala Lys Asp Ala Asp Ile Gly Ser Asn Gly Tyr Ile Arg Tyr Ser
1985                1990                1995                2000
Leu Tyr Gly Ser Gly Asn Ser Glu Phe Phe Leu Asp Pro Glu Ser Gly
                2005                2010                2015    
Glu Leu Lys Thr Leu Ala Leu Leu Asp Arg Glu Arg Ile Pro Val Tyr
            2020                2025                2030        
Ser Leu Met Ala Lys Ala Thr Asp Gly Gly Gly Arg Phe Cys Gln Ser
        2035                2040                2045            
Asn Ile His Leu Ile Leu Glu Asp Val Asn Asp Asn Pro Pro Val Phe
    2050                2055                2060                
Ser Ser Asp His Tyr Asn Thr Cys Val Tyr Glu Asn Thr Ala Thr Lys
2065                2070                2075                2080
Ala Leu Leu Thr Arg Val Gln Ala Val Asp Pro Asp Ile Gly Ile Asn
                2085                2090                2095    
Arg Lys Val Val Tyr Ser Leu Ala Asp Ser Ala Gly Gly Val Phe Ser
            2100                2105                2110        
Ile Asp Ser Ser Ser Gly Ile Ile Ile Leu Glu Gln Pro Leu Asp Arg
        2115                2120                2125            
Glu Gln Gln Ser Ser Tyr Asn Ile Ser Val Arg Ala Thr Asp Gln Ser
    2130                2135                2140                
Pro Gly Gln Ser Leu Ser Ser Leu Thr Thr Val Thr Ile Thr Val Leu
2145                2150                2155                2160
Asp Ile Asn Asp Asn Pro Pro Val Phe Glu Arg Arg Asp Tyr Leu Val
                2165                2170                2175    
Thr Val Pro Glu Asp Thr Ser Pro Gly Thr Gln Val Leu Ala Val Phe
            2180                2185                2190        
Ala Thr Ser Lys Asp Ile Gly Thr Asn Ala Glu Ile Thr Tyr Leu Ile
        2195                2200                2205            
Arg Ser Gly Asn Glu Gln Gly Lys Phe Lys Ile Asn Pro Lys Thr Gly
    2210                2215                2220                
Gly Ile Ser Val Ser Glu Val Leu Asp Tyr Glu Leu Cys Lys Arg Phe
2225                2230                2235                2240
Tyr Leu Val Val Glu Ala Lys Asp Gly Gly Thr Pro Ala Leu Ser Ala
                2245                2250                2255    
Val Ala Thr Val Asn Ile Asn Leu Thr Asp Val Asn Asp Asn Pro Pro
            2260                2265                2270        
Lys Phe Ser Gln Asp Val Tyr Ser Ala Val Ile Ser Glu Asp Ala Leu
        2275                2280                2285            
Val Gly Asp Ser Val Ile Leu Leu Ile Ala Glu Asp Val Asp Ser Gln
    2290                2295                2300                
Pro Asn Gly Gln Ile His Phe Ser Ile Val Asn Gly Asp Arg Asp Asn
2305                2310                2315                2320
Glu Phe Thr Val Asp Pro Val Leu Gly Leu Val Lys Val Lys Lys Lys
                2325                2330                2335    
Leu Asp Arg Glu Arg Val Ser Gly Tyr Ser Leu Leu Val Gln Ala Val
            2340                2345                2350        
Asp Ser Gly Ile Pro Ala Met Ser Ser Thr Ala Thr Val Asn Ile Asp
        2355                2360                2365            
Ile Ser Asp Val Asn Asp Asn Ser Pro Val Phe Thr Pro Ala Asn Tyr
    2370                2375                2380                
Thr Ala Val Ile Gln Glu Asn Lys Pro Val Gly Thr Ser Ile Leu Gln
2385                2390                2395                2400
Leu Val Val Thr Asp Arg Asp Ser Phe His Asn Gly Pro Pro Phe Ser
                2405                2410                2415    
Phe Ser Ile Leu Ser Gly Asn Glu Glu Glu Glu Phe Val Leu Asp Pro
            2420                2425                2430        
His Gly Ile Leu Arg Ser Ala Val Val Phe Gln His Thr Glu Ser Leu
        2435                2440                2445            
Glu Tyr Val Leu Cys Val Gln Ala Lys Asp Ser Gly Lys Pro Gln Gln
    2450                2455                2460                
Val Ser His Thr Tyr Ile Arg Val Arg Val Ile Glu Glu Ser Thr His
2465                2470                2475                2480
Lys Pro Thr Ala Ile Pro Leu Glu Ile Phe Ile Val Thr Met Glu Asp
                2485                2490                2495    
Asp Phe Pro Gly Gly Val Ile Gly Lys Ile His Ala Thr Asp Gln Asp
            2500                2505                2510        
Met Tyr Asp Val Leu Thr Phe Ala Leu Lys Ser Glu Gln Lys Ser Leu
        2515                2520                2525            
Phe Lys Val Asn Ser His Asp Gly Lys Ile Ile Ala Leu Gly Gly Leu
    2530                2535                2540                
Asp Ser Gly Lys Tyr Val Leu Asn Val Ser Val Ser Asp Gly Arg Phe
2545                2550                2555                2560
Gln Val Pro Ile Asp Val Val Val His Val Glu Gln Leu Val His Glu
                2565                2570                2575    
Met Leu Gln Asn Thr Val Thr Ile Arg Phe Glu Asn Val Ser Pro Glu
            2580                2585                2590        
Asp Phe Val Gly Leu His Met His Gly Phe Arg Arg Thr Leu Arg Asn
        2595                2600                2605            
Ala Val Leu Thr Gln Lys Gln Asp Ser Leu Arg Ile Ile Ser Ile Gln
    2610                2615                2620                
Pro Val Ala Gly Thr Asn Gln Leu Asp Met Leu Phe Ala Val Glu Met
2625                2630                2635                2640
His Ser Ser Glu Phe Tyr Lys Pro Ala Tyr Leu Ile Gln Lys Leu Ser
                2645                2650                2655    
Asn Ala Arg Arg His Leu Glu Asn Ile Met Arg Ile Ser Ala Ile Leu
            2660                2665                2670        
Glu Lys Asn Cys Ser Gly Leu Asp Cys Gln Glu Gln His Cys Glu Gln
        2675                2680                2685            
Gly Leu Ser Leu Asp Ser His Ala Leu Met Thr Tyr Ser Thr Ala Arg
    2690                2695                2700                
Ile Ser Phe Val Cys Pro Arg Phe Tyr Arg Asn Val Arg Cys Thr Cys
2705                2710                2715                2720
Asn Gly Gly Leu Cys Pro Gly Ser Asn Asp Pro Cys Val Glu Lys Pro
                2725                2730                2735    
Cys Pro Gly Asp Met Gln Cys Val Ser Tyr Glu Ala Ser Arg Arg Pro
            2740                2745                2750        
Phe Leu Cys Gln Cys Pro Pro Gly Lys Leu Gly Glu Cys Ser Gly His
        2755                2760                2765            
Thr Ser Leu Ser Phe Ala Gly Asn Ser Tyr Ile Lys Tyr Arg Leu Ser
    2770                2775                2780                
Glu Asn Ser Lys Glu Glu Asp Phe Lys Leu Ala Leu Arg Leu Arg Thr
2785                2790                2795                2800
Leu Gln Ser Asn Gly Ile Ile Met Tyr Thr Arg Ala Asn Pro Cys Ile
                2805                2810                2815    
Ile Leu Lys Ile Val Asp Gly Lys Leu Trp Phe Gln Leu Asp Cys Gly
            2820                2825                2830        
Ser Gly Pro Gly Ile Leu Gly Ile Ser Gly Arg Ala Val Asn Asp Gly
        2835                2840                2845            
Ser Trp His Ser Val Phe Leu Glu Leu Asn Arg Asn Phe Thr Ser Leu
    2850                2855                2860                
Ser Leu Asp Asp Ser Tyr Val Glu Arg Arg Arg Ala Pro Leu Tyr Phe
2865                2870                2875                2880
Gln Thr Leu Ser Thr Glu Ser Ser Ile Tyr Phe Gly Ala Leu Val Gln
                2885                2890                2895    
Ala Asp Asn Ile Arg Ser Leu Thr Asp Thr Arg Val Thr Gln Val Leu
            2900                2905                2910        
Ser Gly Phe Gln Gly Cys Leu Asp Ser Val Ile Leu Asn Asn Asn Glu
        2915                2920                2925            
Leu Pro Leu Gln Asn Lys Arg Ser Ser Phe Ala Glu Val Val Gly Leu
    2930                2935                2940                
Thr Glu Leu Lys Leu Gly Cys Val Leu Tyr Pro Asp Ala Cys Lys Arg
2945                2950                2955                2960
Ser Pro Cys Gln His Gly Gly Ser Cys Thr Gly Leu Pro Ser Gly Gly
                2965                2970                2975    
Tyr Gln Cys Thr Cys Leu Ser Gln Phe Thr Gly Arg Asn Cys Glu Ser
            2980                2985                2990        
Glu Ile Thr Ala Cys Phe Pro Asn Pro Cys Arg Asn Gly Gly Ser Cys
        2995                3000                3005            
Asp Pro Ile Gly Asn Thr Phe Ile Cys Asn Cys Lys Ala Gly Leu Thr
    3010                3015                3020                
Gly Val Thr Cys Glu Glu Asp Ile Asn Glu Cys Glu Arg Glu Glu Cys
3025                3030                3035                3040
Glu Asn Gly Gly Ser Cys Val Asn Val Phe Gly Ser Phe Leu Cys Asn
                3045                3050                3055    
Cys Thr Pro Gly Tyr Val Gly Gln Tyr Cys Gly Leu Arg Pro Val Val
            3060                3065                3070        
Val Pro Asn Ile Gln Ala Gly His Ser Tyr Val Gly Lys Glu Glu Leu
        3075                3080                3085            
Ile Gly Ile Ala Val Val Leu Phe Val Ile Phe Ile Leu Val Val Leu
    3090                3095                3100                
Phe Ile Val Phe Arg Lys Lys Val Phe Arg Lys Asn Tyr Ser Arg Asn
3105                3110                3115                3120
Asn Ile Thr Leu Val Gln Asp Pro Ala Thr Ala Ala Leu Leu Asn Lys
                3125                3130                3135    
Ser Asn Gly Ile Pro Phe Arg Asn Leu Arg Gly Ser Gly Asp Gly Arg
            3140                3145                3150        
Asn Val Tyr Gln Glu Val Gly Pro Pro Gln Val Pro Val Arg Pro Met
        3155                3160                3165            
Ala Tyr Thr Pro Cys Phe Gln Ser Asp Ser Arg Ser Asn Leu Asp Lys
    3170                3175                3180                
Ile Val Asp Gly Leu Gly Gly Glu His Gln Glu Met Thr Thr Phe His
3185                3190                3195                3200
Pro Glu Ser Pro Arg Ile Leu Thr Ala Arg Arg Gly Val Val Val Cys
                3205                3210                3215    
Ser Val Ala Pro Asn Leu Pro Ala Val Ser Pro Cys Arg Ser Asp Cys
            3220                3225                3230        
Asp Ser Ile Arg Lys Asn Gly Trp Asp Ala Gly Thr Glu Asn Lys Gly
        3235                3240                3245            
Val Asp Asp Pro Gly Glu Val Thr Cys Phe Ala Gly Ser Asn Lys Gly
    3250                3255                3260                
Ser Asn Ser Glu Val Gln Ser Leu Ser Ser Phe Gln Ser Asp Ser Gly
3265                3270                3275                3280
Asp Asp Asn Ala Ser Ile Val Thr Val Ile Gln Leu Val Asn Asn Val
                3285                3290                3295    
Val Asp Thr Ile Glu Asn Glu Val Ser Val Met Asp Gln Gly Gln Asn
            3300                3305                3310        
Tyr Asn Arg Ala Tyr His Trp Asp Thr Ser Asp Trp Met Pro Gly Ala
        3315                3320                3325            
Arg Leu Ser Asp Ile Glu Glu Val Pro Asn Tyr Glu Asn Gln Asp Gly
    3330                3335                3340                
Gly Ser Ala His Gln Gly Ser Thr Arg Glu Leu Glu Ser Asp Tyr Tyr
3345                3350                3355                3360
Leu Gly Gly Tyr Asp Ile Asp Ser Glu Tyr Pro Pro Pro His Glu Glu
                3365                3370                3375    
Glu Phe Leu Ser Gln Asp Gln Leu Pro Pro Pro Leu Pro Glu Asp Phe
            3380                3385                3390        
Pro Asp Gln Tyr Glu Ala Leu Pro Pro Ser Gln Pro Val Ser Leu Ala
        3395                3400                3405            
Ser Thr Leu Ser Pro Asp Cys Arg Arg Arg Pro Gln Phe His Pro Ser
    3410                3415                3420                
Gln Tyr Leu Pro Pro His Pro Phe Pro Asn Glu Thr Asp Leu Val Gly
3425                3430                3435                3440
Pro Pro Ala Ser Cys Glu Phe Ser Thr Phe Ala Val Ser Met Asn Gln
                3445                3450                3455    
Gly Thr Glu Pro Thr Gly Pro Ala Asp Ser Val Ser Leu Ser Leu His
            3460                3465                3470        
Asn Ser Arg Gly Thr Ser Ser Ser Asp Val Ser Ala Asn Cys Gly Phe
        3475                3480                3485            
Asp Asp Ser Glu Val Ala Met Ser Asp Tyr Glu Ser Val Gly Glu Leu
    3490                3495                3500                
Ser Leu Ala Ser Leu His Ile Pro Phe Val Glu Thr Gln His Gln Thr
3505                3510                3515                3520
Gln Val
        


<210> 9496
<211> 158
<212> PRT
<213> Homo sapiens

<400> 9496
Met Arg Lys Gly Thr Ser Ile Ala Trp Asn Ser Pro Lys Pro Glu Tyr
 1               5                  10                  15      
Phe Leu Gly Ser Val Asp Lys Ile Pro Asp Lys Asp His Leu Ser Glu
            20                  25                  30          
Glu Lys Asn Phe Lys Glu Ser Cys Leu Phe Asp Arg Asp Leu Arg Glu
        35                  40                  45              
Gln Leu Thr Thr Ile Asp Lys Glu Thr Leu Gln Gly Ala Ala Lys Pro
    50                  55                  60                  
Asp Ala His Phe Arg Thr Met Pro Cys Gly Gln Leu Leu His Phe Leu
65                  70                  75                  80  
Gln Arg Asn Thr Ile Ile Ala Ala Val Ser Gly Val Ala Ile Leu Met
                85                  90                  95      
Ala Ile Val Leu Leu Leu Leu Gly Leu Ala Ser Tyr Ile Arg Lys Lys
            100                 105                 110         
Gln Pro Ser Ser Pro Leu Ala Asn Thr Thr Tyr Asn Ile Phe Ile Met
        115                 120                 125             
Asp Gly Lys Thr Trp Trp His Asn Ser Glu Glu Lys Asn Phe Thr Lys
    130                 135                 140                 
Leu Ala Lys Lys Gln Lys Gln Leu Lys Ser Ser Ser Cys Val
145                 150                 155             


<210> 9497
<211> 1229
<212> PRT
<213> Homo sapiens

<400> 9497
Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn
 1               5                  10                  15      
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg
            20                  25                  30          
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu
        35                  40                  45              
Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro
    50                  55                  60                  
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln
65                  70                  75                  80  
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu
                85                  90                  95      
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu
            100                 105                 110         
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly
        115                 120                 125             
Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu
    130                 135                 140                 
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser
145                 150                 155                 160 
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu
                165                 170                 175     
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe
            180                 185                 190         
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile
        195                 200                 205             
Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala
    210                 215                 220                 
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser
225                 230                 235                 240 
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro
                245                 250                 255     
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu
            260                 265                 270         
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu
        275                 280                 285             
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val
    290                 295                 300                 
Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala
305                 310                 315                 320 
Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Ala Lys Gln
                325                 330                 335     
Gln Asp Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu
            340                 345                 350         
Gly Gly Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu
        355                 360                 365             
Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly
    370                 375                 380                 
Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu
385                 390                 395                 400 
Tyr Phe Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro
                405                 410                 415     
Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile
            420                 425                 430         
Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala
        435                 440                 445             
Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn
    450                 455                 460                 
Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr
465                 470                 475                 480 
Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr
                485                 490                 495     
Val Val Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp
            500                 505                 510         
Pro Ser Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile
        515                 520                 525             
Ala Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu
    530                 535                 540                 
Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu
545                 550                 555                 560 
Gly Phe Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln
                565                 570                 575     
Met Pro Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg
            580                 585                 590         
Lys Ser Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met
        595                 600                 605             
Tyr Ser Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile
    610                 615                 620                 
Leu Asn Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp
625                 630                 635                 640 
Glu Met Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg
                645                 650                 655     
Thr Ile Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp
            660                 665                 670         
Trp Asp Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val
        675                 680                 685             
Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg
    690                 695                 700                 
Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn
705                 710                 715                 720 
Ile Asn Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro
                725                 730                 735     
Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile
            740                 745                 750         
Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp
        755                 760                 765             
Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr
    770                 775                 780                 
Leu Val Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val
785                 790                 795                 800 
Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys
                805                 810                 815     
Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys
            820                 825                 830         
Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val
        835                 840                 845             
Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe
    850                 855                 860                 
Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe
865                 870                 875                 880 
Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met
                885                 890                 895     
Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala
            900                 905                 910         
Thr Glu Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg
        915                 920                 925             
Asn Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His
    930                 935                 940                 
Ala Val Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu
945                 950                 955                 960 
Lys Met Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro
                965                 970                 975     
Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met Gln
            980                 985                 990         
Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn Val
        995                 1000                1005            
Phe Asp Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu Gly
    1010                1015                1020                
Thr Phe Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro Phe
1025                1030                1035                1040
Ser Cys Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe Ile
                1045                1050                1055    
Gly Leu Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro Thr
            1060                1065                1070        
Ser Arg Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys Glu
        1075                1080                1085            
Glu Ile Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp His
    1090                1095                1100                
Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu
1105                1110                1115                1120
Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser Ser
                1125                1130                1135    
Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His Asn
            1140                1145                1150        
Phe Met Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His Ile
        1155                1160                1165            
Pro Leu Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys Gln
    1170                1175                1180                
Asn Ser Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile Asp
1185                1190                1195                1200
Ser Gly Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser Ser
                1205                1210                1215    
Ser Pro Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu
            1220                1225                


<210> 9498
<211> 1198
<212> PRT
<213> Homo sapiens

<400> 9498
Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn
 1               5                  10                  15      
Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg
            20                  25                  30          
Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu
        35                  40                  45              
Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro
    50                  55                  60                  
Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln
65                  70                  75                  80  
Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu
                85                  90                  95      
Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu
            100                 105                 110         
Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly
        115                 120                 125             
Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu
    130                 135                 140                 
Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser
145                 150                 155                 160 
Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu
                165                 170                 175     
Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe
            180                 185                 190         
Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile
        195                 200                 205             
Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala
    210                 215                 220                 
Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser
225                 230                 235                 240 
Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro
                245                 250                 255     
Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu
            260                 265                 270         
Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu
        275                 280                 285             
Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Ala Lys
    290                 295                 300                 
Gln Gln Asp Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala
305                 310                 315                 320 
Glu Gly Gly Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys
                325                 330                 335     
Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile
            340                 345                 350         
Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val
        355                 360                 365             
Leu Tyr Phe Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu
    370                 375                 380                 
Pro Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile
385                 390                 395                 400 
Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu
                405                 410                 415     
Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp
            420                 425                 430         
Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala
        435                 440                 445             
Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met
    450                 455                 460                 
Thr Val Val Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro
465                 470                 475                 480 
Asp Pro Ser Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala
                485                 490                 495     
Ile Ala Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys
            500                 505                 510         
Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu
        515                 520                 525             
Leu Gly Phe Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser
    530                 535                 540                 
Gln Met Pro Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val
545                 550                 555                 560 
Arg Lys Ser Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg
                565                 570                 575     
Met Tyr Ser Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys
            580                 585                 590         
Ile Leu Asn Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg
        595                 600                 605             
Asp Glu Met Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu
    610                 615                 620                 
Arg Thr Ile Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro
625                 630                 635                 640 
Asp Trp Asp Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys
                645                 650                 655     
Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile
            660                 665                 670         
Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp
        675                 680                 685             
Asn Ile Asn Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His
    690                 695                 700                 
Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg
705                 710                 715                 720 
Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile
                725                 730                 735     
Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His
            740                 745                 750         
Thr Leu Val Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln
        755                 760                 765             
Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys
    770                 775                 780                 
Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala
785                 790                 795                 800 
Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile
                805                 810                 815     
Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys
            820                 825                 830         
Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala
        835                 840                 845             
Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln
    850                 855                 860                 
Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu
865                 870                 875                 880 
Ala Thr Glu Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly
                885                 890                 895     
Arg Asn Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly
            900                 905                 910         
His Ala Val Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly
        915                 920                 925             
Glu Lys Met Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser
    930                 935                 940                 
Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe Val Met Met
945                 950                 955                 960 
Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly Glu Arg Asn
                965                 970                 975     
Val Phe Asp Gly Ile Phe Arg Asn Pro Ile Phe Cys Thr Ile Val Leu
            980                 985                 990         
Gly Thr Phe Ala Ile Gln Ile Val Ile Val Gln Phe Gly Gly Lys Pro
        995                 1000                1005            
Phe Ser Cys Ser Pro Leu Gln Leu Asp Gln Trp Met Trp Cys Ile Phe
    1010                1015                1020                
Ile Gly Leu Gly Glu Leu Val Trp Gly Gln Val Ile Ala Thr Ile Pro
1025                1030                1035                1040
Thr Ser Arg Leu Lys Phe Leu Lys Glu Ala Gly Arg Leu Thr Gln Lys
                1045                1050                1055    
Glu Glu Ile Pro Glu Glu Glu Leu Asn Glu Asp Val Glu Glu Ile Asp
            1060                1065                1070        
His Ala Glu Arg Glu Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly
        1075                1080                1085            
Leu Asn Arg Ile Gln Thr Gln Ile Arg Val Val Lys Ala Phe Arg Ser
    1090                1095                1100                
Ser Leu Tyr Glu Gly Leu Glu Lys Pro Glu Ser Arg Thr Ser Ile His
1105                1110                1115                1120
Asn Phe Met Ala His Pro Glu Phe Arg Ile Glu Asp Ser Gln Pro His
                1125                1130                1135    
Ile Pro Leu Ile Asp Asp Thr Asp Leu Glu Glu Asp Ala Ala Leu Lys
            1140                1145                1150        
Gln Asn Ser Ser Pro Pro Ser Ser Leu Asn Lys Asn Asn Ser Ala Ile
        1155                1160                1165            
Asp Ser Gly Ile Asn Leu Thr Thr Asp Thr Ser Lys Ser Ala Thr Ser
    1170                1175                1180                
Ser Ser Pro Gly Ser Pro Ile His Ser Leu Glu Thr Ser Leu
1185                1190                1195            


<210> 9499
<211> 694
<212> PRT
<213> Homo sapiens

<400> 9499
Met Leu Asn Leu Cys Phe Met Leu Thr Arg His Ala Val His Ser Leu
 1               5                  10                  15      
Asp Ser Phe Leu Arg Lys Leu Val Phe Cys Ser Leu Pro Ser Ser Leu
            20                  25                  30          
Pro Ser Pro Thr Gly His Ile Thr Ala Ala Ser Leu Thr Ala Gln Arg
        35                  40                  45              
His Leu Ser Leu Arg Ile Lys Pro Ile Ala Thr Lys Asn Tyr Asn Thr
    50                  55                  60                  
Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln Lys Asn Met Gln
65                  70                  75                  80  
Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala Arg Lys Phe Asp
                85                  90                  95      
Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile Ile Lys Lys Val
            100                 105                 110         
Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu Leu Glu Glu Tyr
        115                 120                 125             
Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser Val Ala Thr Val
    130                 135                 140                 
Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro Asp Leu Thr Asn
145                 150                 155                 160 
Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu Trp Ala Trp Glu
                165                 170                 175     
Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln Phe Tyr Pro Lys
            180                 185                 190         
Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn Gly Tyr Val Asp
        195                 200                 205             
Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro Ser Leu Glu Gln
    210                 215                 220                 
Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu Tyr Leu Asn Leu
225                 230                 235                 240 
His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr Gly Ala Gln His
                245                 250                 255     
Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu Gly Asn Met Trp
            260                 265                 270         
Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val Pro Phe Pro Ser
        275                 280                 285             
Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys Gln Gly Trp Thr
    290                 295                 300                 
Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe Thr Ser Leu Gly
305                 310                 315                 320 
Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser Met Leu Glu Lys
                325                 330                 335     
Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe
            340                 345                 350         
Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr Thr Val Asn Leu
        355                 360                 365             
Glu Asp Leu Val Val Ala His His Glu Met Gly His Ile Gln Tyr Phe
    370                 375                 380                 
Met Gln Tyr Lys Asp Leu Pro Val Ala Leu Arg Glu Gly Ala Asn Pro
385                 390                 395                 400 
Gly Phe His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr
                405                 410                 415     
Pro Lys His Leu His Ser Leu Asn Leu Leu Ser Ser Glu Gly Gly Ser
            420                 425                 430         
Asp Glu His Asp Ile Asn Phe Leu Met Lys Met Ala Leu Asp Lys Ile
        435                 440                 445             
Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp Gln Trp Arg Trp Arg Val
    450                 455                 460                 
Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr Asn Gln Glu Trp Trp Ser
465                 470                 475                 480 
Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro Pro Val Pro Arg Thr Gln
                485                 490                 495     
Gly Asp Phe Asp Pro Gly Ala Lys Phe His Ile Pro Ser Ser Val Pro
            500                 505                 510         
Tyr Ile Arg Tyr Phe Val Ser Phe Ile Ile Gln Phe Gln Phe His Glu
        515                 520                 525             
Ala Leu Cys Gln Ala Ala Gly His Thr Gly Pro Leu His Lys Cys Asp
    530                 535                 540                 
Ile Tyr Gln Ser Lys Glu Ala Gly Gln Arg Leu Ala Thr Ala Met Lys
545                 550                 555                 560 
Leu Gly Phe Ser Arg Pro Trp Pro Glu Ala Met Gln Leu Ile Thr Gly
                565                 570                 575     
Gln Pro Asn Met Ser Ala Ser Ala Met Leu Ser Tyr Phe Lys Pro Leu
            580                 585                 590         
Leu Asp Trp Leu Arg Thr Glu Asn Glu Leu His Gly Glu Lys Leu Gly
        595                 600                 605             
Trp Pro Gln Tyr Asn Trp Thr Pro Asn Ser Ala Arg Ser Glu Gly Pro
    610                 615                 620                 
Leu Pro Asp Ser Gly Arg Val Ser Phe Leu Gly Leu Asp Leu Asp Ala
625                 630                 635                 640 
Gln Gln Ala Arg Val Gly Gln Trp Leu Leu Leu Phe Leu Gly Ile Ala
                645                 650                 655     
Leu Leu Val Ala Thr Leu Gly Leu Ser Gln Arg Leu Phe Ser Ile Arg
            660                 665                 670         
His Arg Ser Leu His Arg His Ser His Gly Pro Gln Phe Gly Ser Glu
        675                 680                 685             
Val Glu Leu Arg His Ser
    690                 


<210> 9500
<211> 403
<212> PRT
<213> Homo sapiens

<400> 9500
Met Gly Ala Glu Phe Thr Lys Asn Asn Gly Arg Gly Lys Cys Glu Pro
 1               5                  10                  15      
Gly Thr Glu Val Leu Glu Glu Gly Glu Gly Cys Trp Glu Pro Gly Tyr
            20                  25                  30          
Pro Leu Val Leu Gly Gln Ser Thr Ala Ile Thr His Leu Asn Ile Gln
        35                  40                  45              
Lys Arg Ser Ala Glu Glu Met Ala Leu Thr Pro Thr Asn Leu Asn Asn
    50                  55                  60                  
Lys Met Ser Leu Gln Met Lys Met Asp Cys Gln Glu Gln Gln Leu Thr
65                  70                  75                  80  
Lys Lys Asn Asn Gly Phe Phe Gln Lys Leu Asn Val Thr Glu Gly Ala
                85                  90                  95      
Met Gln Asp Leu Leu Lys Glu Ile Ile Lys Val Asp His Ile Leu Asp
            100                 105                 110         
Arg Ser Asp Asp Glu Asp Asp Ile Ser Ser Glu Asn Pro Gln Thr Asp
        115                 120                 125             
Phe Leu His Lys Val Asp Thr Glu Lys Trp Gly Met Leu Glu Leu Glu
    130                 135                 140                 
Ala Glu His Asp Gln Asp Leu Ser Lys Gln Asp Lys Gln Glu Thr Asp
145                 150                 155                 160 
Val Asp Glu Asp Pro Gln Ala Ser Thr Ser Leu Gln Phe Ser Lys Lys
                165                 170                 175     
Asn Leu Leu Glu Leu Cys Leu Lys Gly Met Phe Leu Lys Leu Asn Tyr
            180                 185                 190         
Trp Asn Thr Lys Ile Gly Leu Gln Val Lys Glu Leu Gly Ala Asp Tyr
        195                 200                 205             
Ile Asp Gly Thr Glu Lys Ile Asp Asn Ile Ile Lys Lys Ile Asn Val
    210                 215                 220                 
Thr Glu Asn Thr Val Lys Ser Leu Leu Lys Asp Met Leu Thr Leu Lys
225                 230                 235                 240 
Gly Gln Ile Glu Lys Leu Glu Asp Arg Gly Leu Asp Leu Asp Gln Gly
                245                 250                 255     
Thr Ser Thr Glu Val Asn Thr Cys Asn Glu Val Tyr Glu Leu Lys Lys
            260                 265                 270         
Lys Val Ile Glu Arg Leu Glu Asp Leu Cys Lys Asn Val Glu Leu Leu
        275                 280                 285             
Ser Ala Lys Leu Arg Met Tyr Gln Met Glu Ala Glu Asp Thr Asp Ser
    290                 295                 300                 
His Ser Ser Glu Glu Ile Asp Thr Glu Glu Met Glu Ala Leu Leu Pro
305                 310                 315                 320 
Gln Ala Pro Ala Ser Phe Leu Val Gln Lys Ser Pro Pro Arg Asn Thr
                325                 330                 335     
Ala Trp Lys Arg Ala Leu Arg Ile Phe Ile Met Phe Asp Val Leu Thr
            340                 345                 350         
Val Thr Gly Leu Leu Cys Tyr Ile Leu Phe Phe Gly Ala Thr Phe Leu
        355                 360                 365             
Phe Glu Arg Val Leu Leu Arg Met Leu Gly Cys Arg Thr Thr Trp Asp
    370                 375                 380                 
Leu Arg Glu Met Arg Glu Pro Phe Leu Asn Leu Glu Val Glu Ala Leu
385                 390                 395                 400 
Leu Pro Ser
            


<210> 9501
<211> 760
<212> PRT
<213> Homo sapiens

<400> 9501
Met Ser Pro Lys Lys Val Gln Ile Lys Val Glu Glu Lys Glu Asp Glu
 1               5                  10                  15      
Thr Glu Glu Ser Ser Ser Glu Glu Glu Glu Glu Val Glu Asp Lys Leu
            20                  25                  30          
Pro Arg Arg Glu Ser Leu Arg Pro Lys Arg Lys Arg Thr Arg Asp Val
        35                  40                  45              
Ile Asn Glu Asp Asp Pro Glu Pro Glu Pro Glu Asp Glu Glu Thr Arg
    50                  55                  60                  
Lys Ala Arg Glu Lys Glu Arg Arg Arg Arg Leu Lys Arg Gly Ala Glu
65                  70                  75                  80  
Lys Glu Glu Ile Asp Glu Glu Glu Leu Glu Arg Leu Lys Ala Glu Leu
                85                  90                  95      
Asp Glu Lys Arg Gln Ile Ile Ala Thr Val Lys Cys Lys Pro Trp Lys
            100                 105                 110         
Met Glu Lys Lys Ile Glu Val Leu Lys Glu Ala Lys Lys Phe Val Ser
        115                 120                 125             
Glu Asn Glu Gly Ala Leu Gly Lys Gly Lys Gly Lys Arg Trp Phe Ala
    130                 135                 140                 
Phe Lys Met Met Met Ala Lys Lys Trp Ala Lys Phe Leu Arg Asp Phe
145                 150                 155                 160 
Glu Asn Phe Lys Ala Ala Cys Val Pro Trp Glu Asn Lys Ile Lys Ala
                165                 170                 175     
Ile Glu Ser Gln Phe Gly Ser Ser Val Ala Ser Tyr Phe Leu Phe Leu
            180                 185                 190         
Arg Trp Met Tyr Gly Val Asn Met Val Leu Phe Ile Leu Thr Phe Ser
        195                 200                 205             
Leu Ile Met Leu Pro Glu Tyr Leu Trp Gly Leu Pro Tyr Gly Ser Leu
    210                 215                 220                 
Pro Arg Lys Thr Val Pro Arg Ala Glu Glu Ala Ser Ala Ala Asn Phe
225                 230                 235                 240 
Gly Val Leu Tyr Asp Phe Asn Gly Leu Ala Gln Tyr Ser Val Leu Phe
                245                 250                 255     
Tyr Gly Tyr Tyr Asp Asn Lys Arg Thr Ile Gly Trp Met Asn Phe Arg
            260                 265                 270         
Leu Pro Leu Ser Tyr Phe Leu Val Gly Ile Met Cys Ile Gly Tyr Ser
        275                 280                 285             
Phe Leu Val Val Leu Lys Ala Met Thr Lys Asn Ile Gly Asp Asp Gly
    290                 295                 300                 
Gly Gly Asp Asp Asn Thr Phe Asn Phe Ser Trp Lys Val Phe Thr Ser
305                 310                 315                 320 
Trp Asp Tyr Leu Ile Gly Asn Pro Glu Thr Ala Asp Asn Lys Phe Asn
                325                 330                 335     
Ser Ile Thr Met Asn Phe Lys Glu Ala Ile Thr Glu Glu Lys Ala Ala
            340                 345                 350         
Gln Val Glu Glu Asn Val His Leu Ile Arg Phe Leu Arg Phe Leu Ala
        355                 360                 365             
Asn Phe Phe Val Phe Leu Thr Leu Gly Gly Ser Gly Tyr Leu Ile Phe
    370                 375                 380                 
Trp Ala Val Lys Arg Ser Gln Glu Phe Ala Gln Gln Asp Pro Asp Thr
385                 390                 395                 400 
Leu Gly Trp Trp Glu Lys Asn Glu Met Asn Met Val Met Ser Leu Leu
                405                 410                 415     
Gly Met Phe Cys Pro Thr Leu Phe Asp Leu Phe Ala Glu Leu Glu Asp
            420                 425                 430         
Tyr His Pro Leu Ile Ala Leu Lys Trp Leu Leu Gly Arg Ile Phe Ala
        435                 440                 445             
Leu Leu Leu Gly Asn Leu Tyr Val Phe Ile Leu Ala Leu Met Asp Glu
    450                 455                 460                 
Ile Asn Asn Lys Ile Glu Glu Glu Lys Leu Val Lys Ala Asn Ile Thr
465                 470                 475                 480 
Leu Trp Glu Ala Asn Met Ile Lys Ala Tyr Asn Ala Ser Phe Ser Glu
                485                 490                 495     
Asn Ser Thr Gly Pro Pro Phe Phe Val His Pro Ala Asp Val Pro Arg
            500                 505                 510         
Gly Pro Cys Trp Glu Thr Met Val Gly Gln Glu Phe Val Arg Leu Thr
        515                 520                 525             
Val Ser Asp Val Leu Thr Thr Tyr Val Thr Ile Leu Ile Gly Asp Phe
    530                 535                 540                 
Leu Arg Ala Cys Phe Val Arg Phe Cys Asn Tyr Cys Trp Cys Trp Asp
545                 550                 555                 560 
Leu Glu Tyr Gly Tyr Pro Ser Tyr Thr Glu Phe Asp Ile Ser Gly Asn
                565                 570                 575     
Val Leu Ala Leu Ile Phe Asn Gln Gly Met Ile Trp Met Gly Ser Phe
            580                 585                 590         
Phe Ala Pro Ser Leu Pro Gly Ile Asn Ile Leu Arg Leu His Thr Ser
        595                 600                 605             
Met Tyr Phe Gln Cys Trp Ala Val Met Cys Cys Asn Val Pro Glu Ala
    610                 615                 620                 
Arg Val Phe Lys Ala Ser Arg Ser Asn Asn Phe Tyr Leu Gly Met Leu
625                 630                 635                 640 
Leu Leu Ile Leu Phe Leu Ser Thr Met Pro Val Leu Tyr Met Ile Val
                645                 650                 655     
Ser Leu Pro Pro Ser Phe Asp Cys Gly Pro Phe Ser Gly Lys Asn Arg
            660                 665                 670         
Met Phe Glu Val Ile Gly Glu Thr Leu Glu His Asp Phe Pro Ser Trp
        675                 680                 685             
Met Ala Lys Ile Leu Arg Gln Leu Ser Asn Pro Gly Leu Val Ile Ala
    690                 695                 700                 
Val Ile Leu Val Met Val Leu Ala Ile Tyr Tyr Leu Asn Ala Thr Ala
705                 710                 715                 720 
Lys Gly Gln Lys Ala Ala Asn Leu Asp Leu Lys Lys Lys Met Lys Met
                725                 730                 735     
Gln Ala Leu Glu Asn Lys Met Arg Asn Lys Lys Met Ala Ala Ala Arg
            740                 745                 750         
Ala Ala Ala Ala Ala Gly Arg Gln
        755                 760 


<210> 9502
<211> 107
<212> PRT
<213> Homo sapiens

<400> 9502
Met Asn Asp Leu Leu Asp Lys Phe Tyr Thr Tyr Lys Val Gln Ile Leu
 1               5                  10                  15      
His Leu Ala Leu Ile Tyr Phe Leu Val Phe Ile Phe Leu Thr Ile His
            20                  25                  30          
Arg Leu Leu Asn Leu Leu Ala Phe Cys Phe Phe Trp Ile Pro Gln Ala
        35                  40                  45              
Leu Phe Lys Asn Trp Thr Ala Ala Leu Phe Thr Gly Asn Leu Leu Leu
    50                  55                  60                  
Ala Arg Asp Arg Asn Leu Phe Thr Val Val Leu Leu Val Pro Gly Pro
65                  70                  75                  80  
Tyr Asn Glu Leu Cys Met Lys Ala Cys Ala Ala Cys Cys Leu Glu Ser
                85                  90                  95      
Leu Arg Ser Trp Ser Phe Ser Leu Thr Ala Lys
            100                 105         


<210> 9503
<211> 471
<212> PRT
<213> Homo sapiens

<400> 9503
Met Asp Ile Leu Cys Glu Glu Asn Thr Ser Leu Ser Ser Thr Thr Asn
 1               5                  10                  15      
Ser Leu Met Gln Leu Asn Asp Asp Thr Arg Leu Tyr Ser Asn Asp Phe
            20                  25                  30          
Asn Ser Gly Glu Ala Asn Thr Ser Asp Ala Phe Asn Trp Thr Val Asp
        35                  40                  45              
Ser Glu Asn Arg Thr Asn Leu Ser Cys Glu Gly Cys Leu Ser Pro Ser
    50                  55                  60                  
Cys Leu Ser Leu Leu His Leu Gln Glu Lys Asn Trp Ser Ala Leu Leu
65                  70                  75                  80  
Thr Ala Val Val Ile Ile Leu Thr Ile Ala Gly Asn Ile Leu Val Ile
                85                  90                  95      
Met Ala Val Ser Leu Glu Lys Lys Leu Gln Asn Ala Thr Asn Tyr Phe
            100                 105                 110         
Leu Met Ser Leu Ala Ile Ala Asp Met Leu Leu Gly Phe Leu Val Met
        115                 120                 125             
Pro Val Ser Met Leu Thr Ile Leu Tyr Gly Tyr Arg Trp Pro Leu Pro
    130                 135                 140                 
Ser Lys Leu Cys Ala Val Trp Ile Tyr Leu Asp Val Leu Phe Ser Thr
145                 150                 155                 160 
Ala Ser Ile Met His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala
                165                 170                 175     
Ile Gln Asn Pro Ile His His Ser Arg Phe Asn Ser Arg Thr Lys Ala
            180                 185                 190         
Phe Leu Lys Ile Ile Ala Val Trp Thr Ile Ser Val Gly Ile Ser Met
        195                 200                 205             
Pro Ile Pro Val Phe Gly Leu Gln Asp Asp Ser Lys Val Phe Lys Glu
    210                 215                 220                 
Gly Ser Cys Leu Leu Ala Asp Asp Asn Phe Val Leu Ile Gly Ser Phe
225                 230                 235                 240 
Val Ser Phe Phe Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Phe Leu
                245                 250                 255     
Thr Ile Lys Ser Leu Gln Lys Glu Ala Thr Leu Cys Val Ser Asp Leu
            260                 265                 270         
Gly Thr Arg Ala Lys Leu Ala Ser Phe Ser Phe Leu Pro Gln Ser Ser
        275                 280                 285             
Leu Ser Ser Glu Lys Leu Phe Gln Arg Ser Ile His Arg Glu Pro Gly
    290                 295                 300                 
Ser Tyr Thr Gly Arg Arg Thr Met Gln Ser Ile Ser Asn Glu Gln Lys
305                 310                 315                 320 
Ala Cys Lys Val Leu Gly Ile Val Phe Phe Leu Phe Val Val Met Trp
                325                 330                 335     
Cys Pro Phe Phe Ile Thr Asn Ile Met Ala Val Ile Cys Lys Glu Ser
            340                 345                 350         
Cys Asn Glu Asp Val Ile Gly Ala Leu Leu Asn Val Phe Val Trp Ile
        355                 360                 365             
Gly Tyr Leu Ser Ser Ala Val Asn Pro Leu Val Tyr Thr Leu Phe Asn
    370                 375                 380                 
Lys Thr Tyr Arg Ser Ala Phe Ser Arg Tyr Ile Gln Cys Gln Tyr Lys
385                 390                 395                 400 
Glu Asn Lys Lys Pro Leu Gln Leu Ile Leu Val Asn Thr Ile Pro Ala
                405                 410                 415     
Leu Ala Tyr Lys Ser Ser Gln Leu Gln Met Gly Gln Lys Lys Asn Ser
            420                 425                 430         
Lys Gln Asp Ala Lys Thr Thr Asp Asn Asp Cys Ser Met Val Ala Leu
        435                 440                 445             
Gly Lys Gln His Ser Glu Glu Ala Ser Lys Asp Asn Ser Asp Gly Val
    450                 455                 460                 
Asn Glu Lys Val Ser Cys Val
465                 470     


<210> 9504
<211> 645
<212> PRT
<213> Homo sapiens

<400> 9504
Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr Lys Ala Leu Leu
 1               5                  10                  15      
Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Leu
            20                  25                  30          
Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile Ala Leu Phe Ser
        35                  40                  45              
Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala Pro Gln Asn Leu
    50                  55                  60                  
Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met Val Val Tyr Thr
65                  70                  75                  80  
Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys Thr Ala Leu Ala
                85                  90                  95      
Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro Asn Lys Thr His
            100                 105                 110         
Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala Met Gly Ile Ile
        115                 120                 125             
Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe Gln Gly Tyr Asn
    130                 135                 140                 
Ser Pro Leu Trp Lys Glu Asp Phe Ser Ala His Cys Trp Asp Gly Tyr
145                 150                 155                 160 
Gly Glu Phe Ser Cys Thr Leu Thr Lys Tyr Trp Asn Arg Gly Phe Val
                165                 170                 175     
Ala Leu Gln Thr Ala Ile Asn Thr Ala Ile Ile Glu Ile Thr Thr Asn
            180                 185                 190         
His Pro Val Met Glu Glu Leu Met Ser Val Thr Ala Ile Thr Met Lys
        195                 200                 205             
Thr Leu Pro Phe Ile Thr Lys Asn Leu Leu His Asn Glu Met Phe Ile
    210                 215                 220                 
Leu Phe Phe Leu Leu His Phe Ser Pro Leu Val Tyr Phe Ile Ser Leu
225                 230                 235                 240 
Asn Val Thr Lys Glu Arg Lys Lys Ser Lys Asn Leu Met Lys Met Met
                245                 250                 255     
Gly Leu Gln Asp Ser Ala Phe Trp Leu Ser Trp Gly Leu Ile Tyr Ala
            260                 265                 270         
Gly Phe Ile Phe Ile Ile Ser Ile Phe Val Thr Ile Ile Ile Thr Phe
        275                 280                 285             
Thr Gln Ile Ile Val Met Thr Gly Phe Met Val Ile Phe Ile Leu Phe
    290                 295                 300                 
Phe Leu Tyr Gly Leu Ser Leu Val Ala Leu Val Phe Leu Met Ser Val
305                 310                 315                 320 
Leu Leu Lys Lys Ala Val Leu Thr Asn Leu Val Val Phe Leu Leu Thr
                325                 330                 335     
Leu Phe Trp Gly Cys Leu Gly Phe Thr Val Phe Tyr Glu Gln Leu Pro
            340                 345                 350         
Ser Ser Leu Glu Trp Ile Leu Asn Ile Cys Ser Pro Phe Ala Phe Thr
        355                 360                 365             
Thr Gly Met Ile Gln Ile Ile Lys Leu Asp Tyr Asn Leu Asn Gly Val
    370                 375                 380                 
Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Thr Met Ile Ala Thr Phe
385                 390                 395                 400 
Ser Met Leu Leu Leu Asp Gly Leu Ile Tyr Leu Leu Leu Ala Leu Tyr
                405                 410                 415     
Phe Asp Lys Ile Leu Pro Tyr Gly Asp Glu Arg His Tyr Ser Pro Leu
            420                 425                 430         
Phe Phe Leu Asn Ser Ser Ser Cys Phe Gln His Gln Arg Thr Asn Ala
        435                 440                 445             
Lys Val Ile Glu Lys Glu Ile Asp Ala Glu His Pro Ser Asp Asp Tyr
    450                 455                 460                 
Phe Glu Pro Val Ala Pro Glu Phe Gln Gly Lys Glu Ala Ile Arg Ile
465                 470                 475                 480 
Arg Asn Val Lys Lys Glu Tyr Lys Gly Lys Ser Gly Lys Val Glu Ala
                485                 490                 495     
Leu Lys Gly Leu Leu Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Ile
            500                 505                 510         
Leu Gly His Ser Gly Ala Gly Lys Ser Ser Leu Leu Asn Ile Leu Asn
        515                 520                 525             
Gly Leu Ser Val Pro Thr Glu Gly Ser Val Thr Ile Tyr Asn Lys Asn
    530                 535                 540                 
Leu Ser Glu Met Gln Asp Leu Glu Glu Ile Arg Lys Ile Thr Gly Val
545                 550                 555                 560 
Cys Pro Gln Phe Asn Val Gln Phe Asp Ile Leu Thr Val Lys Glu Asn
                565                 570                 575     
Leu Ser Leu Phe Ala Lys Ile Lys Gly Ile His Leu Lys Glu Val Glu
            580                 585                 590         
Gln Glu Val Gln Arg Ile Leu Leu Glu Leu Asp Met Gln Asn Ile Gln
        595                 600                 605             
Asp Asn Leu Ala Lys His Leu Ser Glu Gly Gln Lys Arg Lys Leu Thr
    610                 615                 620                 
Phe Gly Ile Thr Ile Leu Gly Asp Pro Gln Trp Met Arg Leu Thr Ser
625                 630                 635                 640 
Trp Leu Ile Glu Lys
                645 


<210> 9505
<211> 594
<212> PRT
<213> Homo sapiens

<400> 9505
Met Phe Lys Asn Lys Thr Thr Cys Leu Arg Gly Ser Asp Thr Ala Ala
 1               5                  10                  15      
Leu Val Pro Val Pro Leu Ala Thr Pro Leu Leu Leu Glu Gly Arg Ser
            20                  25                  30          
Glu Pro Ser Thr Arg Ala Cys Ala Val Ser Gly Gly Gln Ala Ala Leu
        35                  40                  45              
Pro Gly Ala Pro Val Arg Pro Ala Pro Asp Arg Ala Ala Arg Cys Ala
    50                  55                  60                  
Pro Arg Ala Lys Arg Val Gly Ala Asn Ala Gly Ala Arg Gly Gln Gly
65                  70                  75                  80  
Arg Gly Ala Ala Ala Gly Pro Glu Arg Pro Pro His Val Gln Gly Arg
                85                  90                  95      
Arg Ser Ala Pro Arg Gly Ala Val Gly Ala Arg Arg Ala Leu Leu Gly
            100                 105                 110         
Ala Val Gly Lys Ala Gly Gly Leu Thr Arg Ala Arg Glu Thr Arg Arg
        115                 120                 125             
Arg Gly Glu Glu Gly Val Pro Ala Ala Gly Thr Pro Arg Trp Leu Gln
    130                 135                 140                 
Gln Glu Gly Ala Thr Gln Val Ala Val Arg Leu Pro Leu Val Ser Val
145                 150                 155                 160 
Arg His Asp Gly Pro Leu Pro Leu Ser Ala Val Ala Leu Gly Ala Pro
                165                 170                 175     
Gly Leu Pro Thr Ala Ser Ser Pro Ala Ala Ala Val Thr Ala Ala Ile
            180                 185                 190         
Leu Arg Leu Pro Arg Arg Leu Ala Ala Glu Glu Tyr Ile Phe Leu His
        195                 200                 205             
Tyr Leu Phe Val Phe Ile Phe Leu Lys Gly Leu Tyr Tyr Ser Tyr Phe
    210                 215                 220                 
Lys Thr Ile Val Glu Thr Pro Ser Phe Leu Asn Gly Val Trp Met Ile
225                 230                 235                 240 
Met Asn Asp Lys Leu Thr Glu Tyr Pro Leu Val Ile Asn Thr Leu Lys
                245                 250                 255     
Arg Phe Asn Leu Tyr Pro Glu Val Ile Leu Ala Ser Trp Tyr Trp Ile
            260                 265                 270         
Tyr Thr Lys Ile Met Asp Phe Ile Ala Ile Gln Thr Lys Ile Cys Arg
        275                 280                 285             
Thr Val Thr Arg Gly Glu Gly Leu Ser Pro Thr Glu Ser Cys Glu Gly
    290                 295                 300                 
Leu Gly Asp Leu Ala Cys Phe Tyr Val Ala Val Ile Phe Ile Leu Asn
305                 310                 315                 320 
Gly Leu Met Met Ala Leu Phe Phe Ile Tyr Gly Thr Tyr Leu Ser Gly
                325                 330                 335     
Ser Arg Leu Gly Gly Leu Val Thr Val Leu Cys Phe Phe Phe Ser His
            340                 345                 350         
Gly Glu Cys Thr Cys Val Met Trp Thr Pro Pro Leu Arg Glu Ser Phe
        355                 360                 365             
Ser Tyr Pro Phe Leu Val Leu Gln Met Leu Leu Val Thr His Ile Leu
    370                 375                 380                 
Arg Ala Thr Lys Leu Tyr Arg Gly Ser Leu Ile Ala Leu Cys Ile Ser
385                 390                 395                 400 
Asn Leu Phe Phe Met Leu Pro Trp Gln Phe Ala Gln Phe Val Leu Leu
                405                 410                 415     
Thr Gln Gly Ile Leu Ala Met Lys Pro His Phe Leu Lys Ile Asn Val
            420                 425                 430         
Ser Glu Leu Ser Leu Trp Val Ile Gln Gly Cys Phe Trp Leu Phe Gly
        435                 440                 445             
Thr Val Ile Leu Lys Tyr Leu Thr Ser Lys Ile Phe Gly Ile Ala Asp
    450                 455                 460                 
Asp Gly Tyr Ile Ile Met Gln Ile Asn Val Val Gly Leu Phe Pro Leu
465                 470                 475                 480 
Gly Gln Tyr Phe Leu Glu Leu Leu Asp Phe Gln Met Ser Ala Val Tyr
                485                 490                 495     
Ser Gly Ser Asp Leu Ile Trp Lys Pro Pro Gly Thr Gly Ile Ser Pro
            500                 505                 510         
Ser Val Pro Ser Ser Leu Leu Ser Leu Tyr Leu Glu Leu Pro Ser Trp
        515                 520                 525             
Ser His Ser Thr Leu Pro Phe Thr Arg Met Phe Arg Glu Asn Pro Lys
    530                 535                 540                 
Gly Ile Leu Pro Thr Pro Met Ala Val Val Phe Leu Arg Leu Leu Glu
545                 550                 555                 560 
Gly Arg Thr Leu Ser Ala Phe Leu Gly Phe Ser Ser Ser Leu Gly Pro
                565                 570                 575     
Gly Glu Gly Gln His Tyr Glu Lys Glu Gly Glu Trp Glu Ser His Leu
            580                 585                 590         
Leu Pro
        


<210> 9506
<211> 1797
<212> PRT
<213> Homo sapiens

<400> 9506
Met Asp Asp Arg Cys Tyr Pro Val Ile Phe Pro Asp Glu Arg Asn Phe
 1               5                  10                  15      
Arg Pro Phe Thr Ser Asp Ser Leu Ala Ala Ile Glu Lys Arg Ile Ala
            20                  25                  30          
Ile Gln Lys Glu Lys Lys Lys Ser Lys Asp Gln Thr Gly Glu Val Pro
        35                  40                  45              
Gln Pro Arg Pro Gln Leu Asp Leu Lys Ala Ser Arg Lys Leu Pro Lys
    50                  55                  60                  
Leu Tyr Gly Asp Ile Pro Arg Glu Leu Ile Gly Lys Pro Leu Glu Asp
65                  70                  75                  80  
Leu Asp Pro Phe Tyr Arg Asn His Lys Thr Phe Met Val Leu Asn Arg
                85                  90                  95      
Lys Arg Thr Ile Tyr Arg Phe Ser Ala Lys His Ala Leu Phe Ile Phe
            100                 105                 110         
Gly Pro Phe Asn Ser Ile Arg Ser Leu Ala Ile Arg Val Ser Val His
        115                 120                 125             
Ser Tyr Pro Phe Ile Ala Pro Phe Thr Asn Met Phe Ile Ile Gly Thr
    130                 135                 140                 
Val Ile Ile Asn Cys Val Phe Met Ala Thr Gly Pro Ala Lys Asn Ser
145                 150                 155                 160 
Asn Ser Asn Asn Thr Asp Ile Ala Glu Cys Val Phe Thr Gly Ile Tyr
                165                 170                 175     
Ile Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly Phe Ile Leu Asp
            180                 185                 190         
Glu Phe Ser Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp Ser Ile Val
        195                 200                 205             
Ile Gly Ile Ala Ile Val Ser Tyr Ile Pro Gly Ile Thr Ile Lys Leu
    210                 215                 220                 
Leu Pro Leu Arg Thr Phe Arg Val Phe Arg Ala Leu Lys Ala Ile Ser
225                 230                 235                 240 
Val Val Ser Arg Leu Lys Val Ile Val Gly Ala Leu Leu Arg Ser Val
                245                 250                 255     
Lys Lys Leu Val Asn Val Ile Ile Leu Thr Phe Phe Cys Leu Ser Ile
            260                 265                 270         
Phe Ala Leu Val Gly Gln Gln Leu Phe Met Gly Ser Leu Asn Leu Lys
        275                 280                 285             
Cys Ile Ser Arg Asp Cys Lys Asn Ile Ser Asn Pro Glu Ala Tyr Asp
    290                 295                 300                 
His Cys Phe Glu Lys Lys Glu Asn Ser Pro Glu Phe Lys Met Cys Gly
305                 310                 315                 320 
Ile Trp Met Gly Asn Ser Ala Cys Ser Ile Gln Tyr Glu Cys Lys His
                325                 330                 335     
Thr Lys Ile Asn Pro Asp Tyr Asn Tyr Thr Asn Phe Asp Asn Phe Gly
            340                 345                 350         
Trp Ser Phe Leu Ala Met Phe Arg Leu Met Thr Gln Asp Ser Trp Glu
        355                 360                 365             
Lys Leu Tyr Gln Gln Thr Leu Arg Thr Thr Gly Leu Tyr Ser Val Phe
    370                 375                 380                 
Phe Phe Ile Val Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu
385                 390                 395                 400 
Thr Leu Ala Val Val Thr Met Ala Tyr Glu Glu Gln Asn Lys Asn Val
                405                 410                 415     
Ala Ala Glu Ile Glu Ala Lys Glu Lys Met Phe Gln Glu Ala Gln Gln
            420                 425                 430         
Leu Leu Lys Glu Glu Lys Glu Ala Leu Val Ala Met Gly Ile Asp Arg
        435                 440                 445             
Ser Ser Leu Thr Ser Leu Glu Thr Ser Tyr Phe Thr Pro Lys Lys Arg
    450                 455                 460                 
Lys Leu Phe Gly Asn Lys Lys Arg Lys Ser Phe Phe Leu Arg Glu Ser
465                 470                 475                 480 
Gly Lys Asp Gln Pro Pro Gly Ser Asp Ser Asp Glu Asp Cys Gln Lys
                485                 490                 495     
Lys Pro Gln Leu Leu Glu Gln Thr Lys Arg Leu Ser Gln Asn Leu Ser
            500                 505                 510         
Leu Asp His Phe Asp Glu His Gly Asp Pro Leu Gln Arg Gln Arg Ala
        515                 520                 525             
Leu Ser Ala Val Ser Ile Leu Thr Ile Thr Met Lys Glu Gln Glu Lys
    530                 535                 540                 
Ser Gln Glu Pro Cys Leu Pro Cys Gly Glu Asn Leu Ala Ser Lys Tyr
545                 550                 555                 560 
Leu Val Trp Asn Cys Cys Pro Gln Trp Leu Cys Val Lys Lys Val Leu
                565                 570                 575     
Arg Thr Val Met Thr Asp Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys
            580                 585                 590         
Ile Ile Ile Asn Thr Val Phe Leu Ala Met Glu His His Lys Met Glu
        595                 600                 605             
Ala Ser Phe Glu Lys Met Leu Asn Ile Gly Asn Leu Val Phe Thr Ser
    610                 615                 620                 
Ile Phe Ile Ala Glu Met Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr
625                 630                 635                 640 
His Tyr Phe Arg Arg Gly Trp Asn Ile Phe Asp Ser Ile Val Ala Leu
                645                 650                 655     
Leu Ser Phe Ala Asp Val Met Asn Cys Val Leu Gln Lys Arg Ser Trp
            660                 665                 670         
Pro Phe Leu Arg Ser Phe Arg Val Leu Arg Val Phe Lys Leu Ala Lys
        675                 680                 685             
Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val
    690                 695                 700                 
Gly Ala Leu Gly Ser Leu Thr Val Val Leu Val Ile Val Ile Phe Ile
705                 710                 715                 720 
Phe Ser Val Val Gly Met Gln Leu Phe Gly Arg Ser Phe Asn Ser Gln
                725                 730                 735     
Lys Ser Pro Lys Leu Cys Asn Pro Thr Gly Pro Thr Val Ser Cys Leu
            740                 745                 750         
Arg His Trp His Met Gly Asp Phe Trp His Ser Phe Leu Val Val Phe
        755                 760                 765             
Arg Ile Leu Cys Gly Glu Trp Ile Glu Asn Met Trp Glu Cys Met Gln
    770                 775                 780                 
Glu Ala Asn Ala Ser Ser Ser Leu Cys Val Ile Val Phe Ile Leu Ile
785                 790                 795                 800 
Thr Val Ile Gly Lys Leu Val Val Leu Asn Leu Phe Ile Ala Leu Leu
                805                 810                 815     
Leu Asn Ser Phe Ser Asn Glu Glu Arg Asn Gly Asn Leu Glu Gly Glu
            820                 825                 830         
Ala Arg Lys Thr Lys Val Gln Leu Ala Leu Asp Arg Phe Arg Arg Ala
        835                 840                 845             
Phe Cys Phe Val Arg His Thr Leu Glu His Phe Cys His Lys Trp Cys
    850                 855                 860                 
Arg Lys Gln Asn Leu Pro Gln Gln Lys Glu Val Ala Gly Gly Cys Ala
865                 870                 875                 880 
Ala Gln Ser Lys Asp Ile Ile Pro Leu Val Met Glu Met Lys Arg Gly
                885                 890                 895     
Ser Glu Thr Gln Glu Glu Leu Gly Ile Leu Thr Ser Val Pro Lys Thr
            900                 905                 910         
Leu Gly Val Arg His Asp Trp Thr Trp Leu Ala Pro Leu Ala Glu Glu
        915                 920                 925             
Glu Asp Asp Val Glu Phe Ser Gly Glu Asp Asn Ala Gln Arg Ile Thr
    930                 935                 940                 
Gln Pro Glu Pro Glu Gln Gln Ala Tyr Glu Leu His Gln Glu Asn Lys
945                 950                 955                 960 
Lys Pro Thr Ser Gln Arg Val Gln Ser Val Glu Ile Asp Met Phe Ser
                965                 970                 975     
Glu Asp Glu Pro His Leu Thr Ile Gln Asp Pro Arg Lys Lys Ser Asp
            980                 985                 990         
Val Thr Ser Ile Leu Ser Glu Cys Ser Thr Ile Asp Leu Gln Asp Gly
        995                 1000                1005            
Phe Gly Trp Leu Pro Glu Met Val Pro Lys Lys Gln Pro Glu Arg Cys
    1010                1015                1020                
Leu Pro Lys Gly Phe Gly Cys Cys Phe Pro Cys Cys Ser Val Asp Lys
1025                1030                1035                1040
Arg Lys Pro Pro Trp Val Ile Trp Trp Asn Leu Arg Lys Thr Cys Tyr
                1045                1050                1055    
Gln Ile Val Lys His Ser Trp Phe Glu Ser Phe Ile Ile Phe Val Ile
            1060                1065                1070        
Leu Leu Ser Ser Gly Ala Leu Ile Phe Glu Asp Val His Leu Glu Asn
        1075                1080                1085            
Gln Pro Lys Ile Gln Glu Leu Leu Asn Cys Thr Asp Ile Ile Phe Thr
    1090                1095                1100                
His Ile Phe Ile Leu Glu Met Val Leu Lys Trp Val Ala Phe Gly Phe
1105                1110                1115                1120
Gly Lys Tyr Phe Thr Ser Ala Trp Cys Cys Leu Asp Phe Ile Ile Val
                1125                1130                1135    
Ile Val Ser Val Thr Thr Leu Ile Asn Leu Met Glu Leu Lys Ser Phe
            1140                1145                1150        
Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Gln Phe Glu
        1155                1160                1165            
Gly Met Lys Val Val Val Asn Ala Leu Ile Gly Ala Ile Pro Ala Ile
    1170                1175                1180                
Leu Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Val Phe Cys Ile
1185                1190                1195                1200
Leu Gly Val Tyr Phe Phe Ser Gly Lys Phe Gly Lys Cys Ile Asn Gly
                1205                1210                1215    
Thr Asp Ser Val Ile Asn Tyr Thr Ile Ile Thr Asn Lys Ser Gln Cys
            1220                1225                1230        
Glu Ser Gly Asn Phe Ser Trp Ile Asn Gln Lys Val Asn Phe Asp Asn
        1235                1240                1245            
Val Gly Asn Ala Tyr Leu Ala Leu Leu Gln Val Ala Thr Phe Lys Gly
    1250                1255                1260                
Trp Met Asp Ile Ile Tyr Ala Ala Val Asp Ser Thr Glu Lys Glu Gln
1265                1270                1275                1280
Gln Pro Glu Phe Glu Ser Asn Ser Leu Gly Tyr Ile Tyr Phe Val Val
                1285                1290                1295    
Phe Ile Ile Phe Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val
            1300                1305                1310        
Ile Ile Asp Asn Phe Asn Gln Gln Gln Lys Lys Ile Ser Gly Gln Asp
        1315                1320                1325            
Ile Phe Met Thr Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys
    1330                1335                1340                
Leu Gly Ser Lys Lys Pro Gln Lys Pro Ile Pro Arg Pro Leu Asn Lys
1345                1350                1355                1360
Cys Gln Gly Leu Val Phe Asp Ile Val Thr Ser Gln Ile Phe Asp Ile
                1365                1370                1375    
Ile Ile Ile Ser Leu Ile Ile Leu Asn Met Ile Ser Met Met Ala Glu
            1380                1385                1390        
Ser Tyr Asn Gln Pro Lys Ala Met Lys Ser Ile Leu Asp His Leu Asn
        1395                1400                1405            
Trp Val Phe Val Val Ile Phe Thr Leu Glu Cys Leu Ile Lys Ile Phe
    1410                1415                1420                
Ala Leu Arg Gln Tyr Tyr Phe Thr Asn Gly Trp Asn Leu Phe Asp Cys
1425                1430                1435                1440
Val Val Val Leu Leu Ser Ile Val Ser Thr Met Ile Ser Thr Leu Glu
                1445                1450                1455    
Asn Gln Glu His Ile Pro Phe Pro Pro Thr Leu Phe Arg Ile Val Arg
            1460                1465                1470        
Leu Ala Arg Ile Gly Arg Ile Leu Arg Leu Val Arg Ala Ala Arg Gly
        1475                1480                1485            
Ile Arg Thr Leu Leu Phe Ala Leu Met Met Ser Leu Pro Ser Leu Phe
    1490                1495                1500                
Asn Ile Gly Leu Leu Leu Phe Leu Ile Met Phe Ile Tyr Ala Ile Leu
1505                1510                1515                1520
Gly Met Asn Trp Phe Ser Lys Val Asn Pro Glu Ser Gly Ile Asp Asp
                1525                1530                1535    
Ile Phe Asn Phe Lys Thr Phe Ala Ser Ser Met Leu Cys Leu Phe Gln
            1540                1545                1550        
Ile Ser Thr Ser Ala Gly Trp Asp Ser Leu Leu Ser Pro Met Leu Arg
        1555                1560                1565            
Ser Lys Glu Ser Cys Asn Ser Ser Ser Glu Asn Cys His Leu Pro Gly
    1570                1575                1580                
Ile Ala Thr Ser Tyr Phe Val Ser Tyr Ile Ile Ile Ser Phe Leu Ile
1585                1590                1595                1600
Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Asn Thr Ala
                1605                1610                1615    
Thr Glu Glu Ser Glu Asp Pro Leu Gly Glu Asp Asp Phe Asp Ile Phe
            1620                1625                1630        
Tyr Glu Val Trp Glu Lys Phe Asp Pro Glu Ala Thr Gln Phe Ile Lys
        1635                1640                1645            
Tyr Ser Ala Leu Ser Asp Phe Ala Asp Ala Leu Pro Glu Pro Leu Arg
    1650                1655                1660                
Val Ala Lys Pro Asn Lys Tyr Gln Phe Leu Val Met Asp Leu Pro Met
1665                1670                1675                1680
Val Ser Glu Asp Arg Leu His Cys Met Asp Ile Leu Phe Ala Phe Thr
                1685                1690                1695    
Ala Arg Val Leu Gly Gly Ser Asp Gly Leu Asp Ser Met Lys Ala Met
            1700                1705                1710        
Met Glu Glu Lys Phe Met Glu Ala Asn Pro Leu Lys Lys Leu Tyr Glu
        1715                1720                1725            
Pro Ile Val Thr Thr Thr Lys Arg Lys Glu Glu Glu Arg Gly Ala Ala
    1730                1735                1740                
Ile Ile Gln Lys Ala Phe Arg Lys Tyr Met Met Lys Val Thr Lys Gly
1745                1750                1755                1760
Asp Gln Gly Asp Gln Asn Asp Leu Glu Asn Gly Pro His Ser Pro Leu
                1765                1770                1775    
Gln Thr Leu Cys Asn Gly Asp Leu Ser Ser Phe Gly Val Ala Lys Gly
            1780                1785                1790        
Lys Val His Cys Asp
        1795        


<210> 9507
<211> 959
<212> PRT
<213> Homo sapiens

<400> 9507
Met Thr Glu Tyr Glu Leu Leu Ile Gln Ile Ser Asp Ser Val His Tyr
 1               5                  10                  15      
Thr Glu Gly Ala Leu Val Val Arg Val Leu Asp Val Asn Asp Asn Pro
            20                  25                  30          
Pro Val Phe Ser Gln Asp Phe Tyr Gln Val Thr Val Pro Glu Ser Ile
        35                  40                  45              
Pro Val Gly Tyr Ser Val Leu Thr Leu Ser Ala Thr Asp Leu Glu Ser
    50                  55                  60                  
Asn Glu Asn Ile Ser Tyr Arg Ile Leu Ser Ser Ser Lys Glu Phe Ser
65                  70                  75                  80  
Ile Asp Pro Lys Asn Gly Thr Ile Phe Thr Ile Ser Pro Val Leu Leu
                85                  90                  95      
Leu Asp Thr Ile Ser Thr Thr Arg Phe Leu Val Glu Ala Ser Asp Gly
            100                 105                 110         
Gly Asn Pro Asp Pro Arg Ala Leu Thr Leu Val Glu Ile Gly Ile Glu
        115                 120                 125             
Asp Met Asn Asn Tyr Ala Pro Glu Phe Thr Val Lys Ser Tyr Asn Leu
    130                 135                 140                 
Ser Leu Ser Glu Asp Ala Leu Val Gly Ser Thr Leu Val Thr Phe Ser
145                 150                 155                 160 
Asn Ile Asp His Asp Trp Thr Arg Glu Asn Thr Tyr Val Glu Tyr Ser
                165                 170                 175     
Ile Ile Ser Gly Asn Ser Gln Asn Asn Phe His Val Glu Thr Lys Phe
            180                 185                 190         
Phe His Ser Glu Tyr Pro Tyr Lys Gln Val Gly Tyr Leu Val Leu Leu
        195                 200                 205             
His Ser Leu Asp Arg Glu Ala Ser Ala Ser His Glu Leu Val Ile Leu
    210                 215                 220                 
Ala Ser Asp Ser Gly Cys Pro Pro Leu Ser Ser Thr Ala Val Ile Ser
225                 230                 235                 240 
Ile Gln Val Leu Asp Val Asn Asp Asn Pro Pro Asn Phe Ser Ser Leu
                245                 250                 255     
Ser Tyr His Thr His Val Lys Glu Ser Thr Pro Leu Gly Ser His Ile
            260                 265                 270         
Thr Val Val Ser Ala Asn Asp Arg Asp Thr Gly Ser His Ala Glu Ile
        275                 280                 285             
Ile Tyr Asn Ile Ile Ser Gly Asn Glu Lys Gly His Phe Tyr Leu Glu
    290                 295                 300                 
Glu Asn Thr Gly Val Leu Tyr Leu Ile Lys Pro Leu Asp Tyr Glu Lys
305                 310                 315                 320 
Met Thr Lys Phe Thr Leu Thr Val Gln Ala Ser Asp Ala Glu Lys Lys
                325                 330                 335     
His Phe Ser Phe Ala Val Val Phe Val Ser Val Leu Asp Asp Asn Asp
            340                 345                 350         
His Ala Pro Gln Phe Met Phe Ser Ser Phe Ser Cys Ile Val Pro Glu
        355                 360                 365             
Asn Leu Pro Ile Ser Ser Thr Ile Cys Ser Ile Asn Ala Leu Asp Phe
    370                 375                 380                 
Asp Ala Gly Pro Tyr Gly Glu Leu Thr Tyr Ser Ile Val Ser Pro Cys
385                 390                 395                 400 
Phe Leu Thr His Gly Met Ser Tyr Asp His Asp Leu Phe Leu Ile Asp
                405                 410                 415     
Pro Leu Thr Gly Asp Ile His Ala Lys Gln Ile Leu Asp Tyr Glu Asn
            420                 425                 430         
Gly Asn Lys Tyr Cys Leu Thr Val Gln Ala Lys Asp Lys Gly Asp Ala
        435                 440                 445             
Thr Ala Ser Leu Val Val Trp Val Asp Ile Glu Gly Ile Asp Glu Phe
    450                 455                 460                 
Glu Pro Ile Phe Thr Gln Asp Gln Tyr Phe Phe Thr Leu Pro Glu Lys
465                 470                 475                 480 
Asn Lys Asp Arg Gln Leu Ile Gly Arg Val Glu Ala Ser Asp Ala Asp
                485                 490                 495     
Ala Gly Ile Asp Gly Val Ile Leu Tyr Ser Leu Gly Thr Ser Ser Pro
            500                 505                 510         
Phe Phe Ser Val Asn Arg Thr Asn Gly Asn Ile Tyr Leu Ile Arg Ala
        515                 520                 525             
Leu Pro Leu Ile Lys Ser Gln Leu Asn Lys Glu Asp Thr Leu Glu Met
    530                 535                 540                 
Lys Ile Ile Ala His Ser Pro Lys Ser Asp Ser Lys Phe Ala Ser Cys
545                 550                 555                 560 
Thr Val Phe Val Asn Val Ser Phe Ser Ser Glu Gly Thr Pro Leu Ala
                565                 570                 575     
Val Phe Ala Ser Ser Phe Ser Ile Ser Leu Val Val Ser Phe Leu Val
            580                 585                 590         
Phe Leu Ile Leu Ile Cys Ile Leu Ile Val Met Ile Leu Arg His Lys
        595                 600                 605             
Gln Lys Asp Thr Ile Asn Asn Tyr Glu Glu Lys Lys Thr Ser Ser Leu
    610                 615                 620                 
Asp Ala Asp Leu Arg Val Thr Arg Asp Ala Ser Val Leu Lys Ala Phe
625                 630                 635                 640 
Gln Lys Thr Asp Asp Cys Ser Asn Glu Val Val Pro Val Asp Ala Thr
                645                 650                 655     
Pro Glu Trp Leu Ser Leu Ile Ser Ile Met Glu Lys Asp Ile Val Asn
            660                 665                 670         
Leu Tyr Arg Tyr Ser Asn Ser Ser Gly His Cys Ser Val Glu Gly Glu
        675                 680                 685             
Thr Ala Glu Asp Lys Glu Ile Gln Arg Ile Asn Glu His Pro Tyr Arg
    690                 695                 700                 
Lys Cys Ser Asp Ser Ala Leu Ser Asp His Glu Ser Arg Val Pro Asp
705                 710                 715                 720 
Ser Gly Ile Pro Arg Asp Ser Asp Gln Leu Ser Cys Leu Ser Gly Glu
                725                 730                 735     
Thr Asp Val Met Val Thr Ala Glu Thr Ala Glu Ala Ser Gln Thr Phe
            740                 745                 750         
Gly Glu Gly Asp Gln Gly Glu Gly Cys Ser Thr Thr Cys Ala Gln Asn
        755                 760                 765             
Asn Val Leu Pro Gln Thr Val Gln Lys Arg Glu Ala Lys Glu Ser Ile
    770                 775                 780                 
Leu Ala Asp Val Arg Lys Glu Ser Val Phe Ile Ser Gly Asp Gln Glu
785                 790                 795                 800 
Val Arg Cys Ala Ala Leu Ser Thr Gln Thr Thr Ser Asp His Asp Gly
                805                 810                 815     
Lys Asp Asn Tyr His Trp Asn Tyr Leu Leu Ser Trp Glu Pro Lys Phe
            820                 825                 830         
Gln Pro Leu Ala Ser Val Phe Asn Asp Ile Ala Lys Leu Lys Asp Glu
        835                 840                 845             
His Leu His Met Pro Gly Ile Pro Lys Glu Lys Lys Ser Phe Val Phe
    850                 855                 860                 
Pro Pro Pro Leu Ile Thr Ala Val Ala Gln Pro Gly Ile Lys Ala Val
865                 870                 875                 880 
Pro Pro Arg Met Pro Ala Val Asn Leu Gly Gln Val Pro Pro Lys His
                885                 890                 895     
Pro Arg Ser Pro Ile Pro Tyr His Leu Gly Ser Leu Pro Glu Gly Met
            900                 905                 910         
Thr Pro Asn Phe Ser Pro Ser Leu Ser Leu Leu Thr Met Gln Pro Pro
        915                 920                 925             
Ala Leu Ser Pro Leu Leu Arg Glu Gly Glu Leu Leu Gly Thr His Ile
    930                 935                 940                 
Ser Gly Thr Cys His Glu Leu Lys Ala Glu Asp Glu Val Gln Ile
945                 950                 955                 


<210> 9508
<211> 434
<212> PRT
<213> Homo sapiens

<400> 9508
Val Leu Ala Ala Gln Pro Arg Arg Arg Pro Gly Thr Pro Val Leu Cys
 1               5                  10                  15      
Ala Lys Pro Trp Pro Arg Gly Pro Gly His Gly Pro Gly Ala Arg Gly
            20                  25                  30          
Glu Ala Ala Ser Arg Gly Ala Val Thr Gly Arg Ala Ser Ala Met Lys
        35                  40                  45              
Thr Leu Ile Ala Ala Tyr Ser Gly Val Leu Arg Gly Glu Arg Gln Ala
    50                  55                  60                  
Glu Ala Asp Arg Ser Gln Arg Ser His Gly Gly Pro Ala Leu Ser Arg
65                  70                  75                  80  
Glu Gly Ser Gly Arg Trp Gly Thr Gly Ser Ser Ile Leu Ser Ala Leu
                85                  90                  95      
Gln Asp Leu Phe Ser Val Thr Trp Leu Asn Arg Ser Lys Val Glu Lys
            100                 105                 110         
Gln Leu Gln Val Ile Ser Val Leu Gln Trp Val Leu Ser Phe Leu Val
        115                 120                 125             
Leu Gly Val Ala Cys Ser Ala Ile Leu Met Tyr Ile Phe Cys Thr Asp
    130                 135                 140                 
Cys Trp Leu Ile Ala Val Leu Tyr Phe Thr Trp Leu Val Phe Asp Trp
145                 150                 155                 160 
Asn Thr Pro Lys Lys Gly Gly Arg Arg Ser Gln Trp Val Arg Asn Trp
                165                 170                 175     
Ala Val Trp Arg Tyr Phe Arg Asp Tyr Phe Pro Ile Gln Leu Val Lys
            180                 185                 190         
Thr His Asn Leu Leu Thr Thr Arg Asn Tyr Ile Phe Gly Tyr His Pro
        195                 200                 205             
His Gly Ile Met Gly Leu Gly Ala Phe Cys Asn Phe Ser Thr Glu Ala
    210                 215                 220                 
Thr Glu Val Ser Lys Lys Phe Pro Gly Ile Arg Pro Tyr Leu Ala Thr
225                 230                 235                 240 
Leu Ala Gly Asn Phe Arg Met Pro Val Leu Arg Glu Tyr Leu Met Ser
                245                 250                 255     
Gly Gly Ile Cys Pro Val Ser Arg Asp Thr Ile Asp Tyr Leu Leu Ser
            260                 265                 270         
Lys Asn Gly Ser Gly Asn Ala Ile Ile Ile Val Val Gly Gly Ala Ala
        275                 280                 285             
Glu Ser Leu Ser Ser Met Pro Gly Lys Asn Ala Val Thr Leu Arg Asn
    290                 295                 300                 
Arg Lys Gly Phe Val Lys Leu Ala Leu Arg His Gly Ala Asp Leu Val
305                 310                 315                 320 
Pro Ile Tyr Ser Phe Gly Glu Asn Glu Val Tyr Lys Gln Val Ile Phe
                325                 330                 335     
Glu Glu Gly Ser Trp Gly Arg Trp Val Gln Lys Lys Phe Gln Lys Tyr
            340                 345                 350         
Ile Gly Phe Ala Pro Cys Ile Phe His Gly Arg Gly Leu Phe Ser Ser
        355                 360                 365             
Asp Thr Trp Gly Leu Val Pro Tyr Ser Lys Pro Ile Thr Thr Val Val
    370                 375                 380                 
Gly Glu Pro Ile Thr Ile Pro Lys Leu Glu His Pro Thr Gln Gln Asp
385                 390                 395                 400 
Ile Asp Leu Tyr His Thr Met Tyr Met Glu Ala Leu Val Lys Leu Phe
                405                 410                 415     
Asp Lys His Lys Thr Lys Phe Gly Leu Pro Glu Thr Glu Val Leu Glu
            420                 425                 430         
Val Asn
        


<210> 9509
<211> 462
<212> PRT
<213> Homo sapiens

<400> 9509
Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu
 1               5                  10                  15      
Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln
            20                  25                  30          
Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile
        35                  40                  45              
Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu
    50                  55                  60                  
Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr
65                  70                  75                  80  
Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile
                85                  90                  95      
Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys
            100                 105                 110         
Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile
        115                 120                 125             
Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His
    130                 135                 140                 
Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr
145                 150                 155                 160 
Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln
                165                 170                 175     
Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly
            180                 185                 190         
Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly
        195                 200                 205             
Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln
    210                 215                 220                 
Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser
225                 230                 235                 240 
Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys
                245                 250                 255     
Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val
            260                 265                 270         
Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala
        275                 280                 285             
Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser
    290                 295                 300                 
Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met
305                 310                 315                 320 
Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile
                325                 330                 335     
Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp
            340                 345                 350         
Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val
        355                 360                 365             
Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His
    370                 375                 380                 
Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr
385                 390                 395                 400 
Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys
                405                 410                 415     
Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val
            420                 425                 430         
Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr
        435                 440                 445             
Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys
    450                 455                 460         


<210> 9510
<211> 728
<212> PRT
<213> Homo sapiens

<400> 9510
Met Cys Ala Ser Val Lys Tyr Asn Ile Arg Gly Pro Ala Leu Ile Pro
 1               5                  10                  15      
Arg Met Lys Thr Lys His Arg Ile Tyr Tyr Ile Thr Leu Phe Ser Ile
            20                  25                  30          
Val Leu Leu Gly Leu Ile Ala Thr Gly Met Phe Gln Phe Trp Pro His
        35                  40                  45              
Ser Ile Glu Ser Ser Asn Asp Trp Asn Val Glu Lys Arg Ser Ile Arg
    50                  55                  60                  
Asp Val Pro Val Val Arg Leu Pro Ala Asp Ser Pro Ile Pro Glu Arg
65                  70                  75                  80  
Gly Asp Leu Ser Cys Arg Met His Thr Cys Phe Asp Val Tyr Arg Cys
                85                  90                  95      
Gly Phe Asn Pro Lys Asn Lys Ile Lys Val Tyr Ile Tyr Ala Leu Lys
            100                 105                 110         
Lys Tyr Val Asp Asp Phe Gly Val Ser Val Ser Asn Thr Ile Ser Arg
        115                 120                 125             
Glu Tyr Asn Glu Leu Leu Met Ala Ile Ser Asp Ser Asp Tyr Tyr Thr
    130                 135                 140                 
Asp Asp Ile Asn Arg Ala Cys Leu Phe Val Pro Ser Ile Asp Val Leu
145                 150                 155                 160 
Asn Gln Asn Thr Leu Arg Ile Lys Glu Thr Ala Gln Ala Met Ala Gln
                165                 170                 175     
Leu Ser Arg Trp Asp Arg Gly Thr Asn His Leu Leu Phe Asn Met Leu
            180                 185                 190         
Pro Gly Gly Pro Pro Asp Tyr Asn Thr Ala Leu Asp Val Pro Arg Asp
        195                 200                 205             
Arg Ala Leu Leu Ala Gly Gly Gly Phe Ser Thr Trp Thr Tyr Arg Gln
    210                 215                 220                 
Gly Tyr Asp Val Ser Ile Pro Val Tyr Ser Pro Leu Ser Ala Glu Val
225                 230                 235                 240 
Asp Leu Pro Glu Lys Gly Pro Gly Pro Arg Gln Tyr Phe Leu Leu Ser
                245                 250                 255     
Ser Gln Val Gly Leu His Pro Glu Tyr Arg Glu Asp Leu Glu Ala Leu
            260                 265                 270         
Gln Val Lys His Gly Glu Ser Val Leu Val Leu Asp Lys Cys Thr Asn
        275                 280                 285             
Leu Ser Glu Gly Val Leu Ser Val Arg Lys Arg Cys His Lys His Gln
    290                 295                 300                 
Val Phe Asp Tyr Pro Gln Val Leu Gln Glu Ala Thr Phe Cys Val Val
305                 310                 315                 320 
Leu Arg Gly Ala Arg Leu Gly Gln Ala Val Leu Ser Asp Val Leu Gln
                325                 330                 335     
Ala Gly Cys Val Pro Val Val Ile Ala Asp Ser Tyr Ile Leu Pro Phe
            340                 345                 350         
Ser Glu Val Leu Asp Trp Lys Arg Ala Ser Val Val Val Pro Glu Glu
        355                 360                 365             
Lys Met Ser Asp Val Tyr Ser Ile Leu Gln Ser Ile Pro Gln Arg Gln
    370                 375                 380                 
Ile Glu Glu Met Gln Arg Gln Leu Phe Met Glu Pro Val Arg Arg Glu
385                 390                 395                 400 
Asn Trp Ser Ala Ala Asn His Gln Met Asn Ser Leu Ile Trp Pro Arg
                405                 410                 415     
Glu Gln Trp Asp Ser Gln Ile Ile Asn Asp Arg Ile Tyr Pro Tyr Ala
            420                 425                 430         
Ala Ile Ser Tyr Glu Glu Trp Asn Asp Pro Pro Ala Val Lys Trp Gly
        435                 440                 445             
Ser Val Ser Asn Pro Leu Phe Leu Pro Leu Ile Pro Pro Gln Ser Gln
    450                 455                 460                 
Gly Phe Thr Ala Ile Val Leu Thr Tyr Asp Arg Val Glu Ser Leu Phe
465                 470                 475                 480 
Arg Val Ile Thr Glu Val Ser Lys Val Pro Ser Leu Ser Lys Leu Leu
                485                 490                 495     
Val Val Trp Asn Asn Gln Asn Lys Asn Pro Pro Glu Asp Ser Leu Trp
            500                 505                 510         
Pro Lys Ile Arg Val Pro Leu Lys Val Val Arg Thr Ala Glu Asn Lys
        515                 520                 525             
Leu Ser Asn Arg Phe Phe Pro Tyr Asp Glu Ile Glu Thr Glu Ala Val
    530                 535                 540                 
Leu Ala Ile Asp Asp Asp Ile Ile Met Leu Thr Ser Asp Glu Leu Gln
545                 550                 555                 560 
Phe Gly Tyr Glu Val Trp Arg Glu Phe Pro Asp Arg Leu Val Gly Tyr
                565                 570                 575     
Pro Gly Arg Leu His Leu Trp Asp His Glu Met Asn Lys Trp Lys Tyr
            580                 585                 590         
Glu Ser Glu Trp Thr Asn Glu Val Ser Met Val Leu Thr Gly Ala Ala
        595                 600                 605             
Phe Tyr His Lys Tyr Phe Asn Tyr Leu Tyr Thr Tyr Lys Met Pro Gly
    610                 615                 620                 
Asp Ile Lys Asn Trp Val Asp Ala His Met Asn Cys Glu Asp Ile Ala
625                 630                 635                 640 
Met Asn Phe Leu Val Ala Asn Val Thr Gly Lys Ala Val Ile Lys Val
                645                 650                 655     
Thr Pro Arg Lys Lys Phe Lys Cys Pro Glu Cys Thr Ala Ile Asp Gly
            660                 665                 670         
Leu Ser Leu Asp Gln Thr His Met Val Glu Arg Ser Glu Cys Ile Asn
        675                 680                 685             
Lys Phe Ala Ser Val Phe Gly Thr Met Pro Leu Lys Val Val Glu His
    690                 695                 700                 
Arg Ala Asp Pro Val Leu Tyr Lys Asp Asp Phe Pro Glu Lys Leu Lys
705                 710                 715                 720 
Ser Phe Pro Asn Ile Gly Ser Leu
                725             


<210> 9511
<211> 718
<212> PRT
<213> Homo sapiens

<400> 9511
Met Cys Ala Ser Val Lys Tyr Asn Ile Arg Gly Pro Ala Leu Ile Pro
 1               5                  10                  15      
Arg Met Lys Thr Lys His Arg Ile Tyr Tyr Ile Thr Leu Phe Ser Ile
            20                  25                  30          
Val Leu Leu Gly Leu Ile Ala Thr Gly Met Phe Gln Phe Trp Pro His
        35                  40                  45              
Ser Ile Glu Ser Ser Asn Asp Trp Asn Val Glu Lys Arg Ser Ile Arg
    50                  55                  60                  
Asp Val Pro Val Val Arg Leu Pro Ala Asp Ser Pro Ile Pro Glu Arg
65                  70                  75                  80  
Gly Asp Leu Ser Cys Arg Met His Thr Cys Phe Asp Val Tyr Arg Cys
                85                  90                  95      
Gly Phe Asn Pro Lys Asn Lys Ile Lys Val Tyr Ile Tyr Ala Leu Lys
            100                 105                 110         
Lys Tyr Val Asp Asp Phe Gly Val Ser Val Ser Asn Thr Ile Ser Arg
        115                 120                 125             
Glu Tyr Asn Glu Leu Leu Met Ala Ile Ser Asp Ser Asp Tyr Tyr Thr
    130                 135                 140                 
Asp Asp Ile Asn Arg Ala Cys Leu Phe Val Pro Ser Ile Asp Val Leu
145                 150                 155                 160 
Asn Gln Asn Thr Leu Arg Ile Lys Glu Thr Ala Gln Ala Met Ala Gln
                165                 170                 175     
Leu Ser Arg Trp Asp Arg Gly Thr Asn His Leu Leu Phe Asn Met Leu
            180                 185                 190         
Pro Gly Gly Pro Pro Asp Tyr Asn Thr Ala Leu Asp Val Pro Arg Asp
        195                 200                 205             
Arg Ala Leu Leu Ala Gly Gly Gly Phe Ser Thr Trp Thr Tyr Arg Gln
    210                 215                 220                 
Gly Tyr Asp Val Ser Ile Pro Val Tyr Ser Pro Leu Ser Ala Glu Val
225                 230                 235                 240 
Asp Leu Pro Glu Lys Gly Pro Gly Pro Arg Gln Tyr Phe Leu Leu Ser
                245                 250                 255     
Ser Gln Val Gly Leu His Pro Glu Tyr Arg Glu Asp Leu Glu Ala Leu
            260                 265                 270         
Gln Val Lys His Gly Glu Ser Val Leu Val Leu Asp Lys Cys Thr Asn
        275                 280                 285             
Leu Ser Glu Gly Val Leu Ser Val Arg Lys Arg Cys His Lys His Gln
    290                 295                 300                 
Val Phe Asp Tyr Pro Gln Val Leu Gln Glu Ala Thr Phe Cys Val Val
305                 310                 315                 320 
Leu Arg Gly Ala Arg Leu Gly Gln Ala Val Leu Ser Asp Val Leu Gln
                325                 330                 335     
Ala Gly Cys Val Pro Val Val Ile Ala Asp Ser Tyr Ile Leu Pro Phe
            340                 345                 350         
Ser Glu Val Leu Asp Trp Lys Arg Ala Ser Val Val Val Pro Glu Glu
        355                 360                 365             
Lys Met Ser Asp Val Tyr Ser Ile Leu Gln Ser Ile Pro Gln Arg Gln
    370                 375                 380                 
Ile Glu Glu Met Gln Arg Gln Ala Arg Trp Phe Trp Glu Ala Tyr Phe
385                 390                 395                 400 
Gln Ser Ile Lys Ala Ile Ala Leu Ala Thr Leu Gln Ile Ile Asn Asp
                405                 410                 415     
Arg Ile Tyr Pro Tyr Ala Ala Ile Ser Tyr Glu Glu Trp Asn Asp Pro
            420                 425                 430         
Pro Ala Val Lys Trp Gly Ser Val Ser Asn Pro Leu Phe Leu Pro Leu
        435                 440                 445             
Ile Pro Pro Gln Ser Gln Gly Phe Thr Ala Ile Val Leu Thr Tyr Asp
    450                 455                 460                 
Arg Val Glu Ser Leu Phe Arg Val Ile Thr Glu Val Ser Lys Val Pro
465                 470                 475                 480 
Ser Leu Ser Lys Leu Leu Val Val Trp Asn Asn Gln Asn Lys Asn Pro
                485                 490                 495     
Pro Glu Asp Ser Leu Trp Pro Lys Ile Arg Val Pro Leu Lys Val Val
            500                 505                 510         
Arg Thr Ala Glu Asn Lys Leu Ser Asn Arg Phe Phe Pro Tyr Asp Glu
        515                 520                 525             
Ile Glu Thr Glu Ala Val Leu Ala Ile Asp Asp Asp Ile Ile Met Leu
    530                 535                 540                 
Thr Ser Asp Glu Leu Gln Phe Gly Tyr Glu Val Trp Arg Glu Phe Pro
545                 550                 555                 560 
Asp Arg Leu Val Gly Tyr Pro Gly Arg Leu His Leu Trp Asp His Glu
                565                 570                 575     
Met Asn Lys Trp Lys Tyr Glu Ser Glu Trp Thr Asn Glu Val Ser Met
            580                 585                 590         
Val Leu Thr Gly Ala Ala Phe Tyr His Lys Tyr Phe Asn Tyr Leu Tyr
        595                 600                 605             
Thr Tyr Lys Met Pro Gly Asp Ile Lys Asn Trp Val Asp Ala His Met
    610                 615                 620                 
Asn Cys Glu Asp Ile Ala Met Asn Phe Leu Val Ala Asn Val Thr Gly
625                 630                 635                 640 
Lys Ala Val Ile Lys Val Thr Pro Arg Lys Lys Phe Lys Cys Pro Glu
                645                 650                 655     
Cys Thr Ala Ile Asp Gly Leu Ser Leu Asp Gln Thr His Met Val Glu
            660                 665                 670         
Arg Ser Glu Cys Ile Asn Lys Phe Ala Ser Val Phe Gly Thr Met Pro
        675                 680                 685             
Leu Lys Val Val Glu His Arg Ala Asp Pro Val Leu Tyr Lys Asp Asp
    690                 695                 700                 
Phe Pro Glu Lys Leu Lys Ser Phe Pro Asn Ile Gly Ser Leu
705                 710                 715             


<210> 9512
<211> 128
<212> PRT
<213> Homo sapiens

<400> 9512
Met His Ile Val Phe Tyr Arg Gln Lys Ile Ile Gln Lys Tyr Ala Lys
 1               5                  10                  15      
Asn Cys Arg Glu Ala Tyr Lys Thr Leu Ser Ser Leu Tyr Ser Glu Met
            20                  25                  30          
Gln Lys Met Asn Glu Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu
        35                  40                  45              
Cys Ile Asp Val Glu Asp Ala Met Asn Ile Thr Arg Lys Leu Trp Ser
    50                  55                  60                  
Arg Thr Phe Asn Cys Ser Val Pro Cys Ser Asp Thr Val Pro Val Ile
65                  70                  75                  80  
Ala Val Ser Val Phe Ile Leu Phe Leu Pro Val Val Phe Tyr Leu Ser
                85                  90                  95      
Ser Phe Leu His Ser Glu Gln Lys Lys Arg Lys Leu Ile Leu Pro Lys
            100                 105                 110         
Arg Leu Lys Ser Ser Thr Ser Phe Ala Asn Ile Gln Glu Asn Ser Asn
        115                 120                 125             


<210> 9513
<211> 829
<212> PRT
<213> Homo sapiens

<400> 9513
Met Leu Ser Cys Pro Lys Lys Thr Phe Thr Lys Gln His Ile Asn Ile
 1               5                  10                  15      
Gly Phe Lys Lys Lys Gly Pro Glu Glu Asn Ala Val Gln Gln Thr Leu
            20                  25                  30          
Cys Gln Gly Thr Gly Gly Thr Gly Gln His Leu Gly Gly Thr Ser Gly
        35                  40                  45              
Gln Pro Ala Thr Thr Ala Arg Thr Pro Pro Ala Ala Ser Thr Thr Glu
    50                  55                  60                  
Ala Ala Glu Asn Pro Ala Leu Tyr Gln Arg Gly Lys Cys Gly Gly Val
65                  70                  75                  80  
Arg Glu Glu Gly Ile His Pro His Pro Pro Lys Pro Phe Ser Ser Pro
                85                  90                  95      
Phe Leu Ala Ser Asp Ile Gly Ala Leu Asn Glu Leu Glu Leu Cys Leu
            100                 105                 110         
Trp Arg Ala Gly Trp Ser Leu Leu Leu Cys Asp Glu Ile Gly Asp Glu
        115                 120                 125             
Leu Leu Ala Leu Lys Met Leu Leu Trp Ile Leu Leu Leu Glu Thr Ser
    130                 135                 140                 
Leu Cys Phe Ala Ala Gly Asn Val Thr Gly Asp Val Cys Lys Glu Lys
145                 150                 155                 160 
Ile Cys Ser Cys Asn Glu Ile Glu Gly Asp Leu His Val Asp Cys Glu
                165                 170                 175     
Lys Lys Gly Phe Thr Ser Leu Gln Arg Phe Thr Ala Pro Thr Ser Gln
            180                 185                 190         
Phe Tyr His Leu Phe Leu His Gly Asn Ser Leu Thr Arg Leu Phe Pro
        195                 200                 205             
Asn Glu Phe Ala Asn Phe Tyr Asn Ala Val Ser Leu His Met Glu Asn
    210                 215                 220                 
Asn Gly Leu His Glu Ile Val Pro Gly Ala Phe Leu Gly Leu Gln Leu
225                 230                 235                 240 
Val Lys Arg Leu His Ile Asn Asn Asn Lys Ile Lys Ser Phe Arg Lys
                245                 250                 255     
Gln Thr Phe Leu Gly Leu Asp Asp Leu Glu Tyr Leu Gln Ala Asp Phe
            260                 265                 270         
Asn Leu Leu Arg Asp Ile Asp Pro Gly Ala Phe Gln Asp Leu Asn Lys
        275                 280                 285             
Leu Glu Val Leu Ile Leu Asn Asp Asn Leu Ile Ser Thr Leu Pro Ala
    290                 295                 300                 
Asn Val Phe Gln Tyr Val Pro Ile Thr His Leu Asp Leu Arg Gly Asn
305                 310                 315                 320 
Arg Leu Lys Thr Leu Pro Tyr Glu Glu Val Leu Glu Gln Ile Pro Gly
                325                 330                 335     
Ile Ala Glu Ile Leu Leu Glu Asp Asn Pro Trp Asp Cys Thr Cys Asp
            340                 345                 350         
Leu Leu Ser Leu Lys Glu Trp Leu Glu Asn Ile Pro Lys Asn Ala Leu
        355                 360                 365             
Ile Gly Arg Val Val Cys Glu Ala Pro Thr Arg Leu Gln Gly Lys Asp
    370                 375                 380                 
Leu Asn Glu Thr Thr Glu Gln Asp Leu Cys Pro Leu Lys Asn Arg Val
385                 390                 395                 400 
Asp Ser Ser Leu Pro Ala Pro Pro Ala Gln Glu Glu Thr Phe Ala Pro
                405                 410                 415     
Gly Pro Leu Pro Thr Pro Phe Lys Thr Asn Gly Gln Glu Asp His Ala
            420                 425                 430         
Thr Pro Gly Ser Ala Pro Asn Gly Gly Thr Lys Ile Pro Gly Asn Trp
        435                 440                 445             
Gln Ile Lys Ile Arg Pro Thr Ala Ala Ile Ala Thr Gly Ser Ser Arg
    450                 455                 460                 
Asn Lys Pro Leu Ala Asn Ser Leu Pro Cys Pro Gly Gly Cys Ser Cys
465                 470                 475                 480 
Asp His Ile Pro Gly Ser Gly Leu Lys Met Asn Cys Asn Asn Arg Asn
                485                 490                 495     
Val Ser Ser Leu Ala Asp Leu Lys Pro Lys Leu Ser Asn Val Gln Glu
            500                 505                 510         
Leu Phe Leu Arg Asp Asn Lys Ile His Ser Ile Arg Lys Ser His Phe
        515                 520                 525             
Val Asp Tyr Lys Asn Leu Ile Leu Leu Asp Leu Gly Asn Asn Asn Ile
    530                 535                 540                 
Ala Thr Val Glu Asn Asn Thr Phe Lys Asn Leu Leu Asp Leu Arg Trp
545                 550                 555                 560 
Leu Tyr Met Asp Ser Asn Tyr Leu Asp Thr Leu Ser Arg Glu Lys Phe
                565                 570                 575     
Ala Gly Leu Gln Asn Leu Glu Tyr Leu Asn Val Glu Tyr Asn Ala Ile
            580                 585                 590         
Gln Leu Ile Leu Pro Gly Thr Phe Asn Ala Met Pro Lys Leu Arg Ile
        595                 600                 605             
Leu Ile Leu Asn Asn Asn Leu Leu Arg Ser Leu Pro Val Asp Val Phe
    610                 615                 620                 
Ala Gly Val Ser Leu Ser Lys Leu Ser Leu His Asn Asn Tyr Phe Met
625                 630                 635                 640 
Tyr Leu Pro Val Ala Gly Val Leu Asp Gln Leu Thr Ser Ile Ile Gln
                645                 650                 655     
Ile Asp Leu His Gly Asn Pro Trp Glu Cys Ser Cys Thr Ile Val Pro
            660                 665                 670         
Phe Lys Gln Trp Ala Glu Arg Leu Gly Ser Glu Val Leu Met Ser Asp
        675                 680                 685             
Leu Lys Cys Glu Thr Pro Val Asn Phe Phe Arg Lys Asp Phe Met Leu
    690                 695                 700                 
Leu Ser Asn Asp Glu Ile Cys Pro Gln Leu Tyr Ala Arg Ile Ser Pro
705                 710                 715                 720 
Thr Leu Thr Ser His Ser Lys Asn Ser Thr Gly Leu Ala Glu Thr Gly
                725                 730                 735     
Thr His Ser Asn Ser Tyr Leu Asp Thr Ser Arg Val Ser Ile Ser Val
            740                 745                 750         
Leu Val Pro Gly Leu Leu Leu Val Phe Val Thr Ser Ala Phe Thr Val
        755                 760                 765             
Val Gly Met Leu Val Phe Ile Leu Arg Asn Arg Lys Arg Ser Lys Arg
    770                 775                 780                 
Arg Asp Ala Asn Ser Ser Ala Ser Glu Ile Asn Ser Leu Gln Thr Val
785                 790                 795                 800 
Cys Asp Ser Ser Tyr Trp His Asn Gly Pro Tyr Asn Ala Asp Gly Ala
                805                 810                 815     
His Arg Val Tyr Asp Cys Gly Ser His Ser Leu Ser Asp
            820                 825                 


<210> 9514
<211> 696
<212> PRT
<213> Homo sapiens

<400> 9514
Met Leu Leu Trp Ile Leu Leu Leu Glu Thr Ser Leu Cys Phe Ala Ala
 1               5                  10                  15      
Gly Asn Val Thr Gly Asp Val Cys Lys Glu Lys Ile Cys Ser Cys Asn
            20                  25                  30          
Glu Ile Glu Gly Asp Leu His Val Asp Cys Glu Lys Lys Gly Phe Thr
        35                  40                  45              
Ser Leu Gln Arg Phe Thr Ala Pro Thr Ser Gln Phe Tyr His Leu Phe
    50                  55                  60                  
Leu His Gly Asn Ser Leu Thr Arg Leu Phe Pro Asn Glu Phe Ala Asn
65                  70                  75                  80  
Phe Tyr Asn Ala Val Ser Leu His Met Glu Asn Asn Gly Leu His Glu
                85                  90                  95      
Ile Val Pro Gly Ala Phe Leu Gly Leu Gln Leu Val Lys Arg Leu His
            100                 105                 110         
Ile Asn Asn Asn Lys Ile Lys Ser Phe Arg Lys Gln Thr Phe Leu Gly
        115                 120                 125             
Leu Asp Asp Leu Glu Tyr Leu Gln Ala Asp Phe Asn Leu Leu Arg Asp
    130                 135                 140                 
Ile Asp Pro Gly Ala Phe Gln Asp Leu Asn Lys Leu Glu Val Leu Ile
145                 150                 155                 160 
Leu Asn Asp Asn Leu Ile Ser Thr Leu Pro Ala Asn Val Phe Gln Tyr
                165                 170                 175     
Val Pro Ile Thr His Leu Asp Leu Arg Gly Asn Arg Leu Lys Thr Leu
            180                 185                 190         
Pro Tyr Glu Glu Val Leu Glu Gln Ile Pro Gly Ile Ala Glu Ile Leu
        195                 200                 205             
Leu Glu Asp Asn Pro Trp Asp Cys Thr Cys Asp Leu Leu Ser Leu Lys
    210                 215                 220                 
Glu Trp Leu Glu Asn Ile Pro Lys Asn Ala Leu Ile Gly Arg Val Val
225                 230                 235                 240 
Cys Glu Ala Pro Thr Arg Leu Gln Gly Lys Asp Leu Asn Glu Thr Thr
                245                 250                 255     
Glu Gln Asp Leu Cys Pro Leu Lys Asn Arg Val Asp Ser Ser Leu Pro
            260                 265                 270         
Ala Pro Pro Ala Gln Glu Glu Thr Phe Ala Pro Gly Pro Leu Pro Thr
        275                 280                 285             
Pro Phe Lys Thr Asn Gly Gln Glu Asp His Ala Thr Pro Gly Ser Ala
    290                 295                 300                 
Pro Asn Gly Gly Thr Lys Ile Pro Gly Asn Trp Gln Ile Lys Ile Arg
305                 310                 315                 320 
Pro Thr Ala Ala Ile Ala Thr Gly Ser Ser Arg Asn Lys Pro Leu Ala
                325                 330                 335     
Asn Ser Leu Pro Cys Pro Gly Gly Cys Ser Cys Asp His Ile Pro Gly
            340                 345                 350         
Ser Gly Leu Lys Met Asn Cys Asn Asn Arg Asn Val Ser Ser Leu Ala
        355                 360                 365             
Asp Leu Lys Pro Lys Leu Ser Asn Val Gln Glu Leu Phe Leu Arg Asp
    370                 375                 380                 
Asn Lys Ile His Ser Ile Arg Lys Ser His Phe Val Asp Tyr Lys Asn
385                 390                 395                 400 
Leu Ile Leu Leu Asp Leu Gly Asn Asn Asn Ile Ala Thr Val Glu Asn
                405                 410                 415     
Asn Thr Phe Lys Asn Leu Leu Asp Leu Arg Trp Leu Tyr Met Asp Ser
            420                 425                 430         
Asn Tyr Leu Asp Thr Leu Ser Arg Glu Lys Phe Ala Gly Leu Gln Asn
        435                 440                 445             
Leu Glu Tyr Leu Asn Val Glu Tyr Asn Ala Ile Gln Leu Ile Leu Pro
    450                 455                 460                 
Gly Thr Phe Asn Ala Met Pro Lys Leu Arg Ile Leu Ile Leu Asn Asn
465                 470                 475                 480 
Asn Leu Leu Arg Ser Leu Pro Val Asp Val Phe Ala Gly Val Ser Leu
                485                 490                 495     
Ser Lys Leu Ser Leu His Asn Asn Tyr Phe Met Tyr Leu Pro Val Ala
            500                 505                 510         
Gly Val Leu Asp Gln Leu Thr Ser Ile Ile Gln Ile Asp Leu His Gly
        515                 520                 525             
Asn Pro Trp Glu Cys Ser Cys Thr Ile Val Pro Phe Lys Gln Trp Ala
    530                 535                 540                 
Glu Arg Leu Gly Ser Glu Val Leu Met Ser Asp Leu Lys Cys Glu Thr
545                 550                 555                 560 
Pro Val Asn Phe Phe Arg Lys Asp Phe Met Leu Leu Ser Asn Asp Glu
                565                 570                 575     
Ile Cys Pro Gln Leu Tyr Ala Arg Ile Ser Pro Thr Leu Thr Ser His
            580                 585                 590         
Ser Lys Asn Ser Thr Gly Leu Ala Glu Thr Gly Thr His Ser Asn Ser
        595                 600                 605             
Tyr Leu Asp Thr Ser Arg Val Ser Ile Ser Val Leu Val Pro Gly Leu
    610                 615                 620                 
Leu Leu Val Phe Val Thr Ser Ala Phe Thr Val Val Gly Met Leu Val
625                 630                 635                 640 
Phe Ile Leu Arg Asn Arg Lys Arg Ser Lys Arg Arg Asp Ala Asn Ser
                645                 650                 655     
Ser Ala Ser Glu Ile Asn Ser Leu Gln Thr Val Cys Asp Ser Ser Tyr
            660                 665                 670         
Trp His Asn Gly Pro Tyr Asn Ala Asp Gly Ala His Arg Val Tyr Asp
        675                 680                 685             
Cys Gly Ser His Ser Leu Ser Asp
    690                 695     


<210> 9515
<211> 597
<212> PRT
<213> Homo sapiens

<400> 9515
Met Glu Ala Glu Pro Pro Leu Tyr Pro Met Ala Gly Ala Ala Gly Pro
 1               5                  10                  15      
Gln Gly Asp Glu Asp Leu Leu Gly Val Pro Asp Gly Pro Glu Ala Pro
            20                  25                  30          
Leu Asp Glu Leu Val Gly Ala Tyr Pro Asn Tyr Asn Glu Glu Glu Glu
        35                  40                  45              
Glu Arg Arg Tyr Tyr Arg Arg Lys Arg Leu Gly Val Leu Lys Asn Val
    50                  55                  60                  
Leu Ala Ala Ser Ala Gly Gly Met Leu Thr Tyr Gly Val Tyr Leu Gly
65                  70                  75                  80  
Leu Leu Gln Met Gln Leu Ile Leu His Tyr Asp Glu Thr Tyr Arg Glu
                85                  90                  95      
Val Lys Tyr Gly Asn Met Gly Leu Pro Asp Ile Asp Ser Lys Met Leu
            100                 105                 110         
Met Gly Ile Asn Val Thr Pro Ile Ala Ala Leu Leu Tyr Thr Pro Val
        115                 120                 125             
Leu Ile Arg Phe Phe Gly Thr Lys Trp Met Met Phe Leu Ala Val Gly
    130                 135                 140                 
Ile Tyr Ala Leu Phe Val Ser Thr Asn Tyr Trp Glu Arg Tyr Tyr Thr
145                 150                 155                 160 
Leu Val Pro Ser Ala Val Ala Leu Gly Met Ala Ile Val Pro Leu Trp
                165                 170                 175     
Ala Ser Met Gly Asn Tyr Ile Thr Arg Met Ala Gln Lys Tyr His Glu
            180                 185                 190         
Tyr Ser His Tyr Lys Glu Gln Asp Gly Gln Gly Met Lys Gln Arg Pro
        195                 200                 205             
Pro Arg Gly Ser His Ala Pro Tyr Leu Leu Val Phe Gln Ala Ile Phe
    210                 215                 220                 
Tyr Ser Phe Phe His Leu Ser Phe Ala Cys Ala Gln Leu Pro Met Ile
225                 230                 235                 240 
Tyr Phe Leu Asn His Tyr Leu Tyr Asp Leu Asn His Thr Leu Tyr Asn
                245                 250                 255     
Val Gln Ser Cys Gly Thr Asn Ser His Gly Ile Leu Ser Gly Phe Asn
            260                 265                 270         
Lys Thr Val Leu Arg Thr Leu Pro Arg Ser Gly Asn Leu Ile Val Val
        275                 280                 285             
Glu Ser Val Leu Met Ala Val Ala Phe Leu Ala Met Leu Leu Val Leu
    290                 295                 300                 
Gly Leu Cys Gly Ala Ala Tyr Arg Pro Thr Glu Glu Ile Asp Leu Arg
305                 310                 315                 320 
Ser Val Gly Trp Gly Asn Ile Phe Gln Leu Pro Phe Lys His Val Arg
                325                 330                 335     
Asp Tyr Arg Leu Arg His Leu Val Pro Phe Phe Ile Tyr Ser Gly Phe
            340                 345                 350         
Glu Val Leu Phe Ala Cys Thr Gly Ile Ala Leu Gly Tyr Gly Val Cys
        355                 360                 365             
Ser Val Gly Leu Glu Arg Leu Ala Tyr Leu Leu Val Ala Tyr Ser Leu
    370                 375                 380                 
Gly Ala Ser Ala Ala Ser Leu Leu Gly Leu Leu Gly Leu Trp Leu Pro
385                 390                 395                 400 
Arg Pro Val Pro Leu Val Ala Gly Ala Gly Val His Leu Leu Leu Thr
                405                 410                 415     
Phe Ile Leu Phe Phe Trp Ala Pro Val Pro Arg Val Leu Gln His Ser
            420                 425                 430         
Trp Ile Leu Tyr Val Ala Ala Ala Leu Trp Gly Val Gly Ser Ala Leu
        435                 440                 445             
Asn Lys Thr Gly Leu Ser Thr Leu Leu Gly Ile Leu Tyr Glu Asp Lys
    450                 455                 460                 
Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr His Trp Trp Gln Ala Val
465                 470                 475                 480 
Ala Ile Phe Thr Val Tyr Leu Gly Ser Ser Leu His Met Lys Ala Lys
                485                 490                 495     
Leu Ala Val Leu Leu Val Thr Leu Val Ala Ala Ala Val Ser Tyr Leu
            500                 505                 510         
Arg Ile Glu Gln Lys Leu Arg Arg Gly Val Ala Pro Arg Gln Pro Arg
        515                 520                 525             
Ile Pro Arg Pro Gln His Lys Val Arg Gly Tyr Arg Tyr Leu Glu Glu
    530                 535                 540                 
Asp Asn Ser Asp Glu Ser Asp Ala Glu Gly Glu His Gly Asp Gly Ala
545                 550                 555                 560 
Glu Glu Glu Ala Pro Pro Ala Gly Pro Arg Pro Gly Pro Glu Pro Ala
                565                 570                 575     
Gly Leu Gly Arg Arg Pro Cys Pro Tyr Glu Gln Ala Gln Gly Gly Asp
            580                 585                 590         
Gly Pro Glu Glu Gln
        595         


<210> 9516
<211> 388
<212> PRT
<213> Homo sapiens

<400> 9516
Met Gln Arg Leu Leu Phe Pro Pro Leu Arg Ala Leu Lys Gly Arg Gln
 1               5                  10                  15      
Tyr Leu Pro Leu Leu Ala Pro Arg Ala Ala Pro Lys Ala Gln Cys Asp
            20                  25                  30          
Cys Ile Arg Arg Pro Leu Arg Pro Gly Gln Tyr Ser Thr Ile Ser Glu
        35                  40                  45              
Val Ala Leu Gln Ser Gly Arg Gly Thr Val Ser Leu Pro Ser Lys Ala
    50                  55                  60                  
Ala Glu Arg Val Val Gly Arg Trp Leu Leu Val Cys Ser Gly Thr Val
65                  70                  75                  80  
Ala Gly Ala Val Ile Leu Gly Gly Val Thr Arg Leu Thr Glu Ser Gly
                85                  90                  95      
Leu Ser Met Val Asp Trp His Leu Ile Lys Glu Met Lys Pro Pro Thr
            100                 105                 110         
Ser Gln Glu Glu Trp Glu Ala Glu Phe Gln Arg Tyr Gln Gln Phe Pro
        115                 120                 125             
Glu Phe Lys Ile Leu Asn His Asp Met Thr Leu Thr Glu Phe Lys Phe
    130                 135                 140                 
Ile Trp Tyr Met Glu Tyr Ser His Arg Met Trp Gly Arg Leu Val Gly
145                 150                 155                 160 
Leu Val Tyr Ile Leu Pro Ala Ala Tyr Phe Trp Arg Lys Gly Trp Leu
                165                 170                 175     
Ser Arg Gly Met Lys Gly Arg Val Leu Ala Leu Cys Gly Leu Val Cys
            180                 185                 190         
Phe Gln Gly Leu Leu Gly Trp Tyr Met Val Lys Ser Gly Leu Glu Glu
        195                 200                 205             
Lys Ser Asp Ser His Asp Ile Pro Arg Val Ser Gln Tyr Arg Leu Ala
    210                 215                 220                 
Ala His Leu Gly Ser Ala Leu Val Leu Tyr Cys Ala Ser Leu Trp Thr
225                 230                 235                 240 
Ser Leu Ser Leu Leu Leu Pro Pro His Lys Leu Pro Glu Thr His Gln
                245                 250                 255     
Leu Leu Gln Leu Arg Arg Phe Ala His Gly Thr Ala Gly Leu Val Phe
            260                 265                 270         
Leu Thr Ala Leu Ser Gly Ala Phe Val Ala Gly Leu Asp Ala Gly Leu
        275                 280                 285             
Val Tyr Asn Ser Phe Pro Lys Met Gly Glu Ser Trp Ile Pro Glu Asp
    290                 295                 300                 
Leu Phe Thr Phe Ser Pro Ile Leu Arg Asn Val Phe Glu Asn Pro Thr
305                 310                 315                 320 
Met Val Gln Phe Asp His Arg Ile Leu Gly Ile Thr Ser Val Thr Ala
                325                 330                 335     
Ile Thr Val Leu Tyr Phe Leu Ser Arg Arg Ile Pro Leu Pro Arg Arg
            340                 345                 350         
Thr Lys Met Ala Ala Val Thr Leu Leu Ala Leu Ala Tyr Thr Gln Gly
        355                 360                 365             
Pro Val Leu Phe Asn Leu Thr Phe Lys Ile Ser Asp Leu Asp Glu Gly
    370                 375                 380                 
Ile Arg Asn Ile
385             


<210> 9517
<211> 427
<212> PRT
<213> Homo sapiens

<400> 9517
Met Gly Gly Asp Leu Val Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys
 1               5                  10                  15      
Arg Leu Leu Glu Gln Glu Lys Ser Leu Ala Gly Trp Ala Leu Val Leu
            20                  25                  30          
Ala Gly Thr Gly Ile Gly Leu Met Val Leu His Ala Glu Met Leu Trp
        35                  40                  45              
Phe Gly Gly Cys Ser Trp Ala Leu Tyr Leu Phe Leu Val Lys Cys Thr
    50                  55                  60                  
Ile Ser Ile Ser Thr Phe Leu Leu Leu Cys Leu Ile Val Ala Phe His
65                  70                  75                  80  
Ala Lys Glu Val Gln Leu Phe Met Thr Asp Asn Gly Leu Arg Asp Trp
                85                  90                  95      
Arg Val Ala Leu Thr Gly Arg Gln Ala Ala Gln Ile Val Leu Glu Leu
            100                 105                 110         
Val Val Cys Gly Leu His Pro Ala Pro Val Arg Gly Pro Pro Cys Val
        115                 120                 125             
Gln Asp Leu Gly Ala Pro Leu Thr Ser Pro Gln Pro Trp Pro Gly Phe
    130                 135                 140                 
Leu Gly Gln Gly Glu Ala Leu Leu Ser Leu Ala Met Leu Leu Arg Leu
145                 150                 155                 160 
Tyr Leu Val Pro Arg Ala Val Leu Leu Arg Ser Gly Val Leu Leu Asn
                165                 170                 175     
Ala Ser Tyr Arg Ser Ile Gly Ala Leu Asn Gln Val Arg Phe Arg His
            180                 185                 190         
Trp Phe Val Ala Lys Leu Tyr Met Asn Thr His Pro Gly Arg Leu Leu
        195                 200                 205             
Leu Gly Leu Thr Leu Gly Leu Trp Leu Thr Thr Ala Trp Val Leu Ser
    210                 215                 220                 
Val Ala Glu Arg Gln Ala Val Asn Ala Thr Gly His Leu Ser Asp Thr
225                 230                 235                 240 
Leu Trp Leu Ile Pro Ile Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val
                245                 250                 255     
Val Pro Gly Thr Met Trp Gly Lys Ile Val Cys Leu Cys Thr Gly Val
            260                 265                 270         
Met Gly Val Cys Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys
        275                 280                 285             
Leu Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe Met Met Asp
    290                 295                 300                 
Ile Gln Tyr Thr Lys Glu Met Lys Glu Ser Ala Ala Arg Val Leu Gln
305                 310                 315                 320 
Glu Ala Trp Met Phe Tyr Lys His Thr Arg Arg Lys Glu Ser His Ala
                325                 330                 335     
Ala Arg Arg His Gln Arg Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg
            340                 345                 350         
Gln Val Arg Leu Lys His Arg Lys Leu Arg Glu Gln Val Asn Ser Met
        355                 360                 365             
Val Asp Ile Ser Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn
    370                 375                 380                 
Leu Ser Ser Ser His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala
385                 390                 395                 400 
Gly Lys Leu Asp Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro
                405                 410                 415     
Arg Gln Leu Pro Glu Pro Ser Gln Gln Ser Lys
            420                 425         


<210> 9518
<211> 387
<212> PRT
<213> Homo sapiens

<400> 9518
Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg
 1               5                  10                  15      
Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr
            20                  25                  30          
Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr
        35                  40                  45              
Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala
    50                  55                  60                  
Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln
65                  70                  75                  80  
Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His
                85                  90                  95      
Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu
            100                 105                 110         
Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro
        115                 120                 125             
Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys
    130                 135                 140                 
Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln
145                 150                 155                 160 
Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His
                165                 170                 175     
Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe
            180                 185                 190         
Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp
        195                 200                 205             
His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly
    210                 215                 220                 
Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp
225                 230                 235                 240 
Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met
                245                 250                 255     
Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile
            260                 265                 270         
Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg
        275                 280                 285             
Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser
    290                 295                 300                 
Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu
305                 310                 315                 320 
Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys
                325                 330                 335     
Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys Arg
            340                 345                 350         
Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met
        355                 360                 365             
Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Pro Arg Leu
    370                 375                 380                 
Thr Asp Thr
385         


<210> 9519
<211> 416
<212> PRT
<213> Homo sapiens

<400> 9519
Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg
 1               5                  10                  15      
Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr
            20                  25                  30          
Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr
        35                  40                  45              
Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala
    50                  55                  60                  
Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln
65                  70                  75                  80  
Arg Ser Tyr Ile Leu Thr Gln Ala Arg Pro Leu Pro Asn Thr Cys Cys
                85                  90                  95      
His Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met
            100                 105                 110         
Leu Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp
        115                 120                 125             
Pro Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val
    130                 135                 140                 
Lys Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu
145                 150                 155                 160 
Gln Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe
                165                 170                 175     
His Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser
            180                 185                 190         
Phe Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro
        195                 200                 205             
Asp His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser
    210                 215                 220                 
Gly Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly
225                 230                 235                 240 
Asp Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg
                245                 250                 255     
Met Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala
            260                 265                 270         
Ile Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys
        275                 280                 285             
Arg Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His
    290                 295                 300                 
Ser Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly
305                 310                 315                 320 
Leu Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser
                325                 330                 335     
Lys Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys
            340                 345                 350         
Arg Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln
        355                 360                 365             
Met Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Trp Leu
    370                 375                 380                 
Tyr Trp Gln Pro Ile Leu Thr Lys Met Gly Phe Met Ser Val Ile Leu
385                 390                 395                 400 
Val Gly Ala Phe Val Gly Trp Thr Leu Phe Phe Gln Gln Asn Ala Leu
                405                 410                 415     


<210> 9520
<211> 353
<212> PRT
<213> Homo sapiens

<400> 9520
Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg
 1               5                  10                  15      
Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr
            20                  25                  30          
Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr
        35                  40                  45              
Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala
    50                  55                  60                  
Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln
65                  70                  75                  80  
Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His
                85                  90                  95      
Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu
            100                 105                 110         
Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro
        115                 120                 125             
Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys
    130                 135                 140                 
Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln
145                 150                 155                 160 
Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His
                165                 170                 175     
Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe
            180                 185                 190         
Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp
        195                 200                 205             
His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly
    210                 215                 220                 
Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp
225                 230                 235                 240 
Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met
                245                 250                 255     
Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile
            260                 265                 270         
Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg
        275                 280                 285             
Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser
    290                 295                 300                 
Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu
305                 310                 315                 320 
Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys
                325                 330                 335     
Met Gln Asp Thr Met Glu Glu Asn Ser Glu Arg Pro Arg Leu Thr Asp
            340                 345                 350         
Thr
    


<210> 9521
<211> 710
<212> PRT
<213> Homo sapiens

<400> 9521
Met Asp Leu Trp Asn Leu Ser Trp Phe Leu Phe Leu Asp Ala Leu Leu
 1               5                  10                  15      
Val Ile Ser Gly Leu Val Phe Ser Phe Tyr Lys His Asn Val Gln Phe
            20                  25                  30          
Phe Val Val Val Val Leu Ile Lys Asp Val Asp Gly Gly Met Asp Gln
        35                  40                  45              
Asp Ile Phe Asp Ile Asn Glu Gly Leu Gly Leu Asp Leu Phe Glu Gly
    50                  55                  60                  
Asp Ile Arg Leu Asp Arg Ala Gln Ile Arg Asn Ser Ile Ile Gly Glu
65                  70                  75                  80  
Lys Tyr Arg Trp Pro His Thr Ile Pro Tyr Val Leu Glu Asp Ser Leu
                85                  90                  95      
Glu Met Asn Ala Lys Gly Val Ile Leu Asn Ala Phe Glu Arg Tyr Arg
            100                 105                 110         
Leu Lys Thr Cys Ile Asp Phe Lys Pro Trp Ala Gly Glu Thr Asn Tyr
        115                 120                 125             
Ile Ser Val Phe Lys Gly Ser Gly Cys Trp Ser Ser Val Gly Asn Arg
    130                 135                 140                 
Arg Val Gly Lys Gln Glu Leu Ser Ile Gly Ala Asn Cys Asp Arg Ile
145                 150                 155                 160 
Ala Thr Val Gln His Glu Phe Leu His Ala Leu Gly Phe Trp His Glu
                165                 170                 175     
Gln Ser Arg Ser Asp Arg Asp Asp Tyr Val Arg Ile Met Trp Asp Arg
            180                 185                 190         
Ile Leu Ser Gly Arg Glu His Asn Phe Asn Thr Tyr Ser Asp Asp Ile
        195                 200                 205             
Ser Asp Ser Leu Asn Val Pro Tyr Asp Tyr Thr Ser Val Met His Tyr
    210                 215                 220                 
Ser Lys Thr Ala Phe Gln Asn Gly Thr Glu Pro Thr Ile Val Thr Arg
225                 230                 235                 240 
Ile Ser Asp Phe Glu Asp Val Ile Gly Gln Arg Met Asp Phe Ser Asp
                245                 250                 255     
Ser Asp Leu Leu Lys Leu Asn Gln Leu Tyr Asn Cys Ser Ser Ser Leu
            260                 265                 270         
Ser Phe Met Asp Ser Cys Ser Phe Glu Leu Glu Asn Val Cys Gly Met
        275                 280                 285             
Ile Gln Ser Ser Gly Asp Asn Ala Asp Trp Gln Arg Val Ser Gln Val
    290                 295                 300                 
Pro Arg Gly Pro Glu Ser Asp His Ser Asn Met Gly Gln Cys Gln Gly
305                 310                 315                 320 
Ser Gly Phe Phe Met His Phe Asp Ser Ser Ser Val Asn Val Gly Ala
                325                 330                 335     
Thr Ala Val Leu Glu Ser Arg Thr Leu Tyr Pro Lys Arg Gly Phe Gln
            340                 345                 350         
Cys Leu Gln Phe Tyr Leu Tyr Asn Ser Gly Ser Glu Ser Asp Gln Leu
        355                 360                 365             
Asn Ile Tyr Ile Arg Glu Tyr Ser Ala Asp Asn Val Asp Gly Asn Leu
    370                 375                 380                 
Thr Leu Val Glu Glu Ile Lys Glu Ile Pro Thr Gly Ser Trp Gln Leu
385                 390                 395                 400 
Tyr His Val Thr Leu Lys Val Thr Lys Lys Phe Arg Val Val Phe Glu
                405                 410                 415     
Gly Arg Lys Gly Ser Gly Ala Ser Leu Gly Gly Leu Ser Ile Asp Asp
            420                 425                 430         
Ile Asn Leu Ser Glu Thr Arg Cys Pro His His Ile Trp His Ile Arg
        435                 440                 445             
Asn Phe Thr Gln Phe Ile Gly Ser Pro Asn Gly Thr Leu Tyr Ser Pro
    450                 455                 460                 
Pro Phe Tyr Ser Ser Lys Gly Tyr Ala Phe Gln Ile Tyr Leu Asn Leu
465                 470                 475                 480 
Ala His Val Thr Asn Ala Gly Ile Tyr Phe His Leu Ile Ser Gly Ala
                485                 490                 495     
Asn Asp Asp Gln Leu Gln Trp Pro Cys Pro Trp Gln Gln Ala Thr Met
            500                 505                 510         
Thr Leu Leu Asp Gln Asn Pro Asp Ile Arg Gln Arg Met Ser Asn Gln
        515                 520                 525             
Arg Ser Ile Thr Thr Asp Pro Phe Met Thr Thr Asp Asn Gly Asn Tyr
    530                 535                 540                 
Phe Trp Asp Arg Pro Ser Lys Val Gly Thr Val Ala Leu Phe Ser Asn
545                 550                 555                 560 
Gly Thr Gln Phe Arg Arg Gly Gly Gly Tyr Gly Thr Ser Ala Phe Ile
                565                 570                 575     
Thr His Glu Arg Leu Lys Ser Arg Asp Phe Ile Lys Gly Asp Asp Val
            580                 585                 590         
Tyr Ile Leu Leu Thr Val Glu Asp Ile Ser His Leu Asn Ser Thr Gln
        595                 600                 605             
Ile Gln Leu Thr Pro Ala Pro Ser Val Gln Asp Leu Cys Ser Lys Thr
    610                 615                 620                 
Thr Cys Lys Asn Asp Gly Val Cys Thr Val Arg Asp Gly Lys Ala Glu
625                 630                 635                 640 
Cys Arg Cys Gln Ser Gly Glu Asp Trp Trp Tyr Met Gly Glu Arg Cys
                645                 650                 655     
Glu Lys Arg Gly Ser Thr Arg Asp Thr Ile Val Ile Ala Val Ser Ser
            660                 665                 670         
Thr Val Ala Val Phe Ala Leu Met Leu Ile Ile Thr Leu Val Ser Val
        675                 680                 685             
Tyr Cys Thr Arg Lys Lys Tyr Arg Glu Arg Met Ser Ser Asn Arg Pro
    690                 695                 700                 
Asn Leu Thr Pro Gln Asn
705                 710 


<210> 9522
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 9522
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu
 1               5                  10                  15      
Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val
            20                  25                  30          
Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser
        35                  40                  45              
Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn
    50                  55                  60                  
Glu Val Glu Thr Thr Ser Leu Asn Asp Val Thr Leu Ser Leu Leu Pro
65                  70                  75                  80  
Ser Asn Glu Thr Glu Lys Thr Lys Ile Thr Ile Val Lys Thr Phe Asn
                85                  90                  95      
Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu Ser Ser Ile
            100                 105                 110         
Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe Gln Tyr Asp
        115                 120                 125             
Lys Glu Ser Thr Val Pro Gln Asn Gln His Ile Thr Asn Gly Thr Leu
    130                 135                 140                 
Thr Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu Leu Asn Lys
145                 150                 155                 160 
Thr Leu Gln Thr Leu Ser Glu Thr Tyr Phe Ile Met Cys Ala Thr Ala
                165                 170                 175     
Glu Ala Gln Ser Thr Leu Asn Cys Thr Phe Thr Ile Lys Leu Asn Asn
            180                 185                 190         
Thr Met Asn Ala Cys Ala Ala Ile Ala Ala Leu Glu Arg Val Lys Ile
        195                 200                 205             
Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro Cys Pro Ser
    210                 215                 220                 
Ser Pro Glu Glu Leu Gly Lys Leu Gln Cys Asp Leu Gln Asp Pro Ile
225                 230                 235                 240 
Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser Ser Ser Gln
                245                 250                 255     
Ser Ile Pro Val Val Pro Arg Ala Thr Val Leu Ser Gln Val Pro Lys
            260                 265                 270         
Ala Thr Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val Thr His Asn
        275                 280                 285             
Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro Gln Pro Ser
    290                 295                 300                 
Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro Gln Ser Glu
305                 310                 315                 320 
Thr Ile Ser Ser Pro Met Pro Gln Thr His Val Ser Gly Thr Pro Pro
                325                 330                 335     
Pro Val Lys Ala Ser Phe Ser Ser Pro Thr Val Ser Ala Pro Ala Asn
            340                 345                 350         
Val Asn Thr Thr Ser Ala Pro Pro Val Gln Thr Asp Ile Val Asn Thr
        355                 360                 365             
Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met Glu Lys Ala
    370                 375                 380                 
Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu Met Ile Asn
385                 390                 395                 400 
Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu Ala Pro Leu
                405                 410                 415     
Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu Gln Leu Asn
            420                 425                 430         
Phe Ser Asn Thr Thr Ile Ser Leu Thr Ser Pro Ser Leu Ala Leu Ala
        435                 440                 445             
Val Ile Arg Val Asn Ala Ser Ser Phe Asn Thr Thr Thr Phe Val Ala
    450                 455                 460                 
Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Thr Gln Ala Pro Glu
465                 470                 475                 480 
Asn Ser Ile Gly Thr Ile Thr Leu Pro Ser Ser Leu Met Asn Asn Leu
                485                 490                 495     
Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe Asn Phe Phe
            500                 505                 510         
Glu Thr Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn Leu Ser Leu
        515                 520                 525             
Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Thr Val Arg Asn
    530                 535                 540                 
Leu Thr Arg Asn Val Thr Val Thr Leu Lys His Ile Asn Pro Ser Gln
545                 550                 555                 560 
Asp Glu Leu Thr Val Arg Cys Val Phe Trp Asp Leu Gly Arg Asn Gly
                565                 570                 575     
Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys Asp Arg Arg
            580                 585                 590         
Leu Asn Glu Thr Ile Cys Thr Cys Ser His Leu Thr Ser Phe Gly Val
        595                 600                 605             
Leu Leu Asp Leu Ser Arg Thr Ser Val Leu Pro Ala Gln Met Met Ala
    610                 615                 620                 
Leu Thr Phe Ile Thr Tyr Ile Gly Cys Gly Leu Ser Ser Ile Phe Leu
625                 630                 635                 640 
Ser Val Thr Leu Val Thr Tyr Ile Ala Phe Glu Lys Ile Arg Arg Asp
                645                 650                 655     
Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu Leu Leu Leu
            660                 665                 670         
Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr Lys Met Gln
        675                 680                 685             
Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe Leu Leu Val
    690                 695                 700                 
Ser Phe Thr Trp Met Gly Leu Glu Ala Phe His Met Tyr Leu Ala Leu
705                 710                 715                 720 
Val Lys Val Phe Asn Thr Tyr Ile Arg Lys Tyr Ile Leu Lys Phe Cys
                725                 730                 735     
Ile Val Gly Trp Gly Val Pro Ala Val Val Val Thr Ile Ile Leu Thr
            740                 745                 750         
Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys Phe Pro Asn
        755                 760                 765             
Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala Val Phe Tyr
    770                 